format-version: 1.2
data-version: releases/2016-04-30
date: 29:04:2016 15:30
saved-by: hjd
auto-generated-by: OBO-Edit 2.3.1
subsetdef: goantislim_grouping "Grouping classes that can be excluded"
subsetdef: gocheck_do_not_annotate "Term not to be used for direct annotation"
subsetdef: gocheck_do_not_manually_annotate "Term not to be used for direct manual annotation"
subsetdef: goslim_aspergillus "Aspergillus GO slim"
subsetdef: goslim_candida "Candida GO slim"
subsetdef: goslim_chembl "ChEMBL protein targets summary"
subsetdef: goslim_generic "Generic GO slim"
subsetdef: goslim_goa "GOA and proteome slim"
subsetdef: goslim_metagenomics "Metagenomics GO slim"
subsetdef: goslim_pir "PIR GO slim"
subsetdef: goslim_plant "Plant GO slim"
subsetdef: goslim_pombe "Fission yeast GO slim"
subsetdef: goslim_synapse "synapse GO slim"
subsetdef: goslim_virus "Viral GO slim"
subsetdef: goslim_yeast "Yeast GO slim"
subsetdef: gosubset_prok "Prokaryotic GO subset"
subsetdef: mf_needs_review "Catalytic activity terms in need of attention"
subsetdef: termgenie_unvetted "Terms created by TermGenie that do not follow a template and require additional vetting by editors"
subsetdef: virus_checked "Viral overhaul terms"
synonymtypedef: systematic_synonym "Systematic synonym" EXACT
default-namespace: gene_ontology
remark: cvs version: $Revision: 32962 $
ontology: go

[Term]
id: GO:0000001
name: mitochondrion inheritance
namespace: biological_process
def: "The distribution of mitochondria, including the mitochondrial genome, into daughter cells after mitosis or meiosis, mediated by interactions between mitochondria and the cytoskeleton." [GOC:mcc, PMID:10873824, PMID:11389764]
synonym: "mitochondrial inheritance" EXACT []
is_a: GO:0048308 ! organelle inheritance
is_a: GO:0048311 ! mitochondrion distribution

[Term]
id: GO:0000002
name: mitochondrial genome maintenance
namespace: biological_process
def: "The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome." [GOC:ai, GOC:vw]
is_a: GO:0007005 ! mitochondrion organization

[Term]
id: GO:0000003
name: reproduction
namespace: biological_process
alt_id: GO:0019952
alt_id: GO:0050876
def: "The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms." [GOC:go_curators, GOC:isa_complete, GOC:jl, ISBN:0198506732]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "reproductive physiological process" EXACT []
xref: Wikipedia:Reproduction
is_a: GO:0008150 ! biological_process
disjoint_from: GO:0044848 ! biological phase

[Term]
id: GO:0000005
name: obsolete ribosomal chaperone activity
namespace: molecular_function
def: "OBSOLETE. Assists in the correct assembly of ribosomes or ribosomal subunits in vivo, but is not a component of the assembled ribosome when performing its normal biological function." [GOC:jl, PMID:12150913]
comment: This term was made obsolete because it refers to a class of gene products and a biological process rather than a molecular function.
synonym: "ribosomal chaperone activity" EXACT []
is_obsolete: true
consider: GO:0042254
consider: GO:0044183
consider: GO:0051082

[Term]
id: GO:0000006
name: high-affinity zinc uptake transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Zn2+(out) = Zn2+(in), probably powered by proton motive force. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [TC:2.A.5.1.1]
synonym: "high affinity zinc uptake transmembrane transporter activity" EXACT []
is_a: GO:0005385 ! zinc ion transmembrane transporter activity

[Term]
id: GO:0000007
name: low-affinity zinc ion transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Zn2+ = Zn2+, probably powered by proton motive force. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0005385 ! zinc ion transmembrane transporter activity

[Term]
id: GO:0000008
name: obsolete thioredoxin
namespace: molecular_function
alt_id: GO:0000013
def: "OBSOLETE. A small disulfide-containing redox protein that serves as a general protein disulfide oxidoreductase. Interacts with a broad range of proteins by a redox mechanism, based on the reversible oxidation of 2 cysteine thiol groups to a disulfide, accompanied by the transfer of 2 electrons and 2 protons. The net result is the covalent interconversion of a disulfide and a dithiol." [GOC:kd]
comment: This term was made obsolete because it represents gene products.
synonym: "thioredoxin" EXACT []
is_obsolete: true
consider: GO:0003756
consider: GO:0015036

[Term]
id: GO:0000009
name: alpha-1,6-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->6) linkage." [GOC:mcc, PMID:2644248]
synonym: "1,6-alpha-mannosyltransferase activity" EXACT []
xref: EC:2.4.1.-
xref: Reactome:REACT_22295 "Addition of a third mannose to the N-glycan precursor by Alg2, Saccharomyces cerevisiae"
xref: Reactome:REACT_22383 "Addition of a third mannose to the N-glycan precursor by ALG2, Homo sapiens"
is_a: GO:0000030 ! mannosyltransferase activity

[Term]
id: GO:0000010
name: trans-hexaprenyltranstransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: all-trans-hexaprenyl diphosphate + isopentenyl diphosphate = all-trans-heptaprenyl diphosphate + diphosphate." [KEGG:R05612, RHEA:20839]
subset: gosubset_prok
xref: KEGG:R05612
xref: RHEA:20839
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0000011
name: vacuole inheritance
namespace: biological_process
def: "The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton." [GOC:mcc, PMID:10873824, PMID:14616069]
is_a: GO:0007033 ! vacuole organization
is_a: GO:0048308 ! organelle inheritance

[Term]
id: GO:0000012
name: single strand break repair
namespace: biological_process
def: "The repair of single strand breaks in DNA. Repair of such breaks is mediated by the same enzyme systems as are used in base excision repair." [http://www.ultranet.com/~jkimball/BiologyPages/D/DNArepair.html]
subset: gosubset_prok
is_a: GO:0006281 ! DNA repair

[Term]
id: GO:0000014
name: single-stranded DNA endodeoxyribonuclease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within a single-stranded deoxyribonucleic acid molecule by creating internal breaks." [GOC:mah]
synonym: "single-stranded DNA specific endodeoxyribonuclease activity" RELATED []
synonym: "ssDNA-specific endodeoxyribonuclease activity" RELATED [GOC:mah]
is_a: GO:0004520 ! endodeoxyribonuclease activity

[Term]
id: GO:0000015
name: phosphopyruvate hydratase complex
namespace: cellular_component
def: "A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "enolase complex" EXACT []
is_a: GO:0044445 ! cytosolic part
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0000016
name: lactase activity
namespace: molecular_function
def: "Catalysis of the reaction: lactose + H2O = D-glucose + D-galactose." [EC:3.2.1.108]
synonym: "lactase-phlorizin hydrolase activity" BROAD [EC:3.2.1.108]
synonym: "lactose galactohydrolase activity" EXACT [EC:3.2.1.108]
xref: EC:3.2.1.108
xref: MetaCyc:LACTASE-RXN
xref: Reactome:REACT_100439 "lactose + H2O => D-glucose + D-galactose, Gallus gallus"
xref: Reactome:REACT_104113 "lactose + H2O => D-glucose + D-galactose, Rattus norvegicus"
xref: Reactome:REACT_105850 "lactose + H2O => D-glucose + D-galactose, Bos taurus"
xref: Reactome:REACT_109208 "lactose + H2O => D-glucose + D-galactose, Taeniopygia guttata"
xref: Reactome:REACT_109391 "lactose + H2O => D-glucose + D-galactose, Sus scrofa"
xref: Reactome:REACT_109447 "lactose + H2O => D-glucose + D-galactose, Danio rerio"
xref: Reactome:REACT_112431 "lactose + H2O => D-glucose + D-galactose, Caenorhabditis elegans"
xref: Reactome:REACT_114967 "lactose + H2O => D-glucose + D-galactose, Drosophila melanogaster"
xref: Reactome:REACT_30821 "lactose + H2O => D-glucose + D-galactose, Mus musculus"
xref: Reactome:REACT_78084 "lactose + H2O => D-glucose + D-galactose, Canis familiaris"
xref: Reactome:REACT_78754 "lactose + H2O => D-glucose + D-galactose, Xenopus tropicalis"
xref: Reactome:REACT_9455 "lactose + H2O => D-glucose + D-galactose, Homo sapiens"
xref: RHEA:10079
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0000017
name: alpha-glucoside transport
namespace: biological_process
def: "The directed movement of alpha-glucosides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Alpha-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in an alpha configuration." [GOC:jl, http://www.biochem.purdue.edu/, ISBN:0198506732]
is_a: GO:0042946 ! glucoside transport

[Term]
id: GO:0000018
name: regulation of DNA recombination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA recombination, a DNA metabolic process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0051052 ! regulation of DNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006310 ! DNA recombination
relationship: regulates GO:0006310 ! DNA recombination

[Term]
id: GO:0000019
name: regulation of mitotic recombination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA recombination during mitosis." [GOC:go_curators]
synonym: "regulation of recombination within rDNA repeats" NARROW []
is_a: GO:0000018 ! regulation of DNA recombination
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006312 ! mitotic recombination
relationship: regulates GO:0006312 ! mitotic recombination

[Term]
id: GO:0000020
name: obsolete negative regulation of recombination within rDNA repeats
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of genetic recombination within the DNA of the genes coding for ribosomal RNA." [GOC:go_curators, ISBN:0198506732]
comment: This term was made obsolete because it describes a substrate-specific process.
synonym: "negative regulation of recombination within rDNA repeats" EXACT []
is_obsolete: true
consider: GO:0045950

[Term]
id: GO:0000022
name: mitotic spindle elongation
namespace: biological_process
def: "The cell cycle process in which the distance is lengthened between poles of the mitotic spindle. Mitotic spindle elongation begins during mitotic prophase and ends during mitotic anaphase B." [GOC:mtg_cell_cycle, GOC:vw]
synonym: "spindle elongation during mitosis" EXACT []
is_a: GO:0051231 ! spindle elongation
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0051231 ! spindle elongation
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0000070 ! mitotic sister chromatid segregation
relationship: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0007052 ! mitotic spindle organization

[Term]
id: GO:0000023
name: maltose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose), an intermediate in the catabolism of glycogen and starch." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "malt sugar metabolic process" EXACT []
synonym: "malt sugar metabolism" EXACT []
synonym: "maltose metabolism" EXACT []
is_a: GO:0005984 ! disaccharide metabolic process

[Term]
id: GO:0000024
name: maltose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose)." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "malt sugar biosynthesis" EXACT []
synonym: "malt sugar biosynthetic process" EXACT []
synonym: "maltose anabolism" EXACT []
synonym: "maltose biosynthesis" EXACT []
synonym: "maltose formation" EXACT []
synonym: "maltose synthesis" EXACT []
is_a: GO:0000023 ! maltose metabolic process
is_a: GO:0046351 ! disaccharide biosynthetic process

[Term]
id: GO:0000025
name: maltose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose)." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "malt sugar catabolic process" EXACT []
synonym: "malt sugar catabolism" EXACT []
synonym: "maltose breakdown" EXACT []
synonym: "maltose degradation" EXACT []
synonym: "maltose hydrolysis" NARROW []
xref: MetaCyc:MALTOSECAT-PWY
is_a: GO:0000023 ! maltose metabolic process
is_a: GO:0046352 ! disaccharide catabolic process

[Term]
id: GO:0000026
name: alpha-1,2-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->2) linkage." [GOC:mcc, PMID:10521541]
xref: EC:2.4.1.-
xref: Reactome:REACT_22123 "Addition of the seventh mannose to the N-glycan precursor by ALG9, inside the ER lumen, Homo sapiens"
xref: Reactome:REACT_22156 "Addition of a fourth and fifth mannose to the N-glycan precursor by ALG11, Homo sapiens"
xref: Reactome:REACT_22220 "Addition of the fourth and fifth mannose to the N-glycan precursor skeleton by Alg11, Saccharomyces cerevisiae"
xref: Reactome:REACT_22307 "Addition of the last mannose to the N-glycan precursor by ALG3, inside the ER lumen., Homo sapiens"
is_a: GO:0000030 ! mannosyltransferase activity

[Term]
id: GO:0000027
name: ribosomal large subunit assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit." [GOC:jl]
subset: gosubset_prok
synonym: "50S ribosomal subunit assembly" NARROW [GOC:mah]
synonym: "60S ribosomal subunit assembly" NARROW [GOC:mah]
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0042255 ! ribosome assembly
relationship: part_of GO:0042273 ! ribosomal large subunit biogenesis

[Term]
id: GO:0000028
name: ribosomal small subunit assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit." [GOC:jl]
subset: gosubset_prok
synonym: "30S ribosomal subunit assembly" NARROW [GOC:mah]
synonym: "40S ribosomal subunit assembly" NARROW [GOC:mah]
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0042255 ! ribosome assembly
relationship: part_of GO:0042274 ! ribosomal small subunit biogenesis

[Term]
id: GO:0000030
name: mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai, GOC:cjm]
subset: gosubset_prok
xref: EC:2.4.1.-
xref: Reactome:REACT_1018 "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate, Homo sapiens"
xref: Reactome:REACT_105204 "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate, Dictyostelium discoideum"
xref: Reactome:REACT_2179 "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI, Homo sapiens"
xref: Reactome:REACT_22117 "Addition of the eighth mannose to the N-glycan precursor by ALG12, inside the ER lumen, Homo sapiens"
xref: Reactome:REACT_30252 "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate, Rattus norvegicus"
xref: Reactome:REACT_34702 "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate, Danio rerio"
xref: Reactome:REACT_63412 "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate, Mus musculus"
xref: Reactome:REACT_87972 "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate, Canis familiaris"
xref: Reactome:REACT_95740 "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate, Gallus gallus"
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups
relationship: part_of GO:0097502 ! mannosylation

[Term]
id: GO:0000031
name: mannosylphosphate transferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a mannosylphosphate group from one compound to another." [GOC:jl]
is_a: GO:0016740 ! transferase activity

[Term]
id: GO:0000032
name: cell wall mannoprotein biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cell wall mannoproteins, any cell wall protein that contains covalently bound mannose residues." [GOC:ai]
subset: gosubset_prok
synonym: "cell wall mannoprotein anabolism" EXACT []
synonym: "cell wall mannoprotein biosynthesis" EXACT []
synonym: "cell wall mannoprotein formation" EXACT []
synonym: "cell wall mannoprotein synthesis" EXACT []
is_a: GO:0006057 ! mannoprotein biosynthetic process
is_a: GO:0031506 ! cell wall glycoprotein biosynthetic process

[Term]
id: GO:0000033
name: alpha-1,3-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->3) linkage." [GOC:mcc, PMID:10521541]
xref: EC:2.4.1.-
xref: Reactome:REACT_22347 "Addition of a second mannose to the N-glycan precursor by ALG2, Homo sapiens"
xref: Reactome:REACT_22415 "Addition of the sixth mannose to the N-glycan precursor by ALG3., Homo sapiens"
is_a: GO:0000030 ! mannosyltransferase activity

[Term]
id: GO:0000034
name: adenine deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: adenine + H2O = hypoxanthine + NH3." [EC:3.5.4.2]
subset: gosubset_prok
synonym: "ADase activity" EXACT [EC:3.5.4.2]
synonym: "adenase activity" EXACT [EC:3.5.4.2]
synonym: "adenine aminase activity" EXACT [EC:3.5.4.2]
synonym: "adenine aminohydrolase activity" EXACT [EC:3.5.4.2]
xref: EC:3.5.4.2
xref: MetaCyc:ADENINE-DEAMINASE-RXN
xref: RHEA:23691
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0000035
name: acyl binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an acyl group, any group formally derived by removal of the hydroxyl group from the acid function of a carboxylic acid." [GOC:curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "acyl-CoA or acyl binding" BROAD []
is_a: GO:0005488 ! binding

[Term]
id: GO:0000036
name: ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process
namespace: molecular_function
def: "Interacting selectively and non-covalently with the attachment site of the phosphopantetheine prosthetic group of an acyl carrier protein (ACP) as part of the process of fatty acid biosynthesis." [CHEBI:22221, GOC:jl, GOC:vw]
comment: Note that this term was moved from transporter to binding because we decided that ACP is not a true transporter, but instead tethers the growing entity that is acted on to make the fatty acid, so binding is the more correct parent. July 2012.
subset: gosubset_prok
synonym: "acyl carrier activity" EXACT []
is_a: GO:0044620 ! ACP phosphopantetheine attachment site binding
intersection_of: GO:0044620 ! ACP phosphopantetheine attachment site binding
intersection_of: part_of GO:0006633 ! fatty acid biosynthetic process
relationship: part_of GO:0006633 ! fatty acid biosynthetic process

[Term]
id: GO:0000038
name: very long-chain fatty acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a fatty acid which has a chain length greater than C22." [CHEBI:27283, GOC:hjd]
subset: gosubset_prok
synonym: "very long chain fatty acid metabolic process" EXACT [GOC:bf]
synonym: "very-long-chain fatty acid metabolic process" EXACT []
synonym: "very-long-chain fatty acid metabolism" EXACT []
is_a: GO:0006631 ! fatty acid metabolic process

[Term]
id: GO:0000039
name: obsolete plasma membrane long-chain fatty acid transporter
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it describes a gene product and it contains component information.
synonym: "plasma membrane long-chain fatty acid transporter" EXACT []
is_obsolete: true
consider: GO:0005324
consider: GO:0005886

[Term]
id: GO:0000040
name: low-affinity iron ion transmembrane transport
namespace: biological_process
def: "A process in which an iron ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. In low-affinity transport the transporter is able to bind the solute only if it is only present at very low concentrations." [GOC:mah]
synonym: "low affinity iron ion transport" BROAD []
synonym: "low-affinity iron ion transport" BROAD []
is_a: GO:0034755 ! iron ion transmembrane transport

[Term]
id: GO:0000041
name: transition metal ion transport
namespace: biological_process
def: "The directed movement of transition metal ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732]
subset: gosubset_prok
synonym: "transition metal transport" EXACT []
is_a: GO:0030001 ! metal ion transport

[Term]
id: GO:0000042
name: protein targeting to Golgi
namespace: biological_process
def: "The process of directing proteins towards the Golgi; usually uses signals contained within the protein." [GOC:ai, GOC:mah]
synonym: "protein-Golgi targeting" EXACT []
is_a: GO:0000301 ! retrograde transport, vesicle recycling within Golgi
is_a: GO:0006605 ! protein targeting
is_a: GO:0034067 ! protein localization to Golgi apparatus
is_a: GO:0072600 ! establishment of protein localization to Golgi
is_a: GO:1902580 ! single-organism cellular localization

[Term]
id: GO:0000044
name: obsolete ascorbate stabilization
namespace: biological_process
def: "OBSOLETE. The reduction of the ascorbate free radical to a stable form." [GOC:ai, GOC:mtg_electron_transport]
comment: This term was made obsolete because it is defined as a function term and is in the process ontology.
synonym: "ascorbate stabilization" EXACT []
synonym: "vitamin C stabilization" EXACT []
is_obsolete: true

[Term]
id: GO:0000045
name: autophagosome assembly
namespace: biological_process
def: "The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm." [GOC:autophagy, PMID:9412464]
synonym: "autophagic vacuole assembly" EXACT [GOC:autophagy]
synonym: "autophagic vacuole formation" RELATED [GOC:mah]
synonym: "autophagosome biosynthesis" EXACT []
synonym: "autophagosome formation" EXACT []
synonym: "PAS formation" NARROW []
is_a: GO:0070925 ! organelle assembly
is_a: GO:1905037 ! autophagosome organization

[Term]
id: GO:0000047
name: obsolete Rieske iron-sulfur protein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "Rieske iron-sulfur protein" EXACT []
synonym: "Rieske iron-sulphur protein" EXACT []
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0000048
name: peptidyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: peptidyl-tRNA(1) + aminoacyl-tRNA(2) = tRNA(1) + peptidylaminoacyl-tRNA(2)." [EC:2.3.2.12, PMID:11433365, PMID:9242921]
synonym: "peptidyl-tRNA:aminoacyl-tRNA N-peptidyltransferase activity" EXACT [EC:2.3.2.12]
xref: EC:2.3.2.12
xref: MetaCyc:PEPTIDYLTRANSFERASE-RXN
xref: Reactome:REACT_102632 "Peptide transfer from P-site tRNA to the A-site tRNA, Saccharomyces cerevisiae"
xref: Reactome:REACT_104123 "Peptide transfer from P-site tRNA to the A-site tRNA, Schizosaccharomyces pombe"
xref: Reactome:REACT_112282 "Peptide transfer from P-site tRNA to the A-site tRNA, Gallus gallus"
xref: Reactome:REACT_115501 "Peptide transfer from P-site tRNA to the A-site tRNA, Rattus norvegicus"
xref: Reactome:REACT_1227 "Peptide transfer from P-site tRNA to the A-site tRNA, Homo sapiens"
xref: Reactome:REACT_28090 "Peptide transfer from P-site tRNA to the A-site tRNA, Arabidopsis thaliana"
xref: Reactome:REACT_31656 "Peptide transfer from P-site tRNA to the A-site tRNA, Taeniopygia guttata"
xref: Reactome:REACT_33679 "Peptide transfer from P-site tRNA to the A-site tRNA, Dictyostelium discoideum"
xref: Reactome:REACT_77497 "Peptide transfer from P-site tRNA to the A-site tRNA, Oryza sativa"
xref: Reactome:REACT_81539 "Peptide transfer from P-site tRNA to the A-site tRNA, Drosophila melanogaster"
xref: Reactome:REACT_87719 "Peptide transfer from P-site tRNA to the A-site tRNA, Mus musculus"
xref: Reactome:REACT_90185 "Peptide transfer from P-site tRNA to the A-site tRNA, Danio rerio"
xref: Reactome:REACT_90457 "Peptide transfer from P-site tRNA to the A-site tRNA, Canis familiaris"
xref: Reactome:REACT_91228 "Peptide transfer from P-site tRNA to the A-site tRNA, Caenorhabditis elegans"
xref: Reactome:REACT_95405 "Peptide transfer from P-site tRNA to the A-site tRNA, Plasmodium falciparum"
xref: Reactome:REACT_98179 "Peptide transfer from P-site tRNA to the A-site tRNA, Xenopus tropicalis"
is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups

[Term]
id: GO:0000049
name: tRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with transfer RNA." [GOC:ai]
subset: gosubset_prok
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0000050
name: urea cycle
namespace: biological_process
alt_id: GO:0006594
alt_id: GO:0006871
def: "The sequence of reactions by which arginine is synthesized from ornithine, then cleaved to yield urea and regenerate ornithine. The overall reaction equation is NH3 + CO2 + aspartate + 3 ATP + 2 H2O = urea + fumarate + 2 ADP + 2 phosphate + AMP + diphosphate." [GOC:pde, GOC:vw, ISBN:0198506732]
synonym: "ornithine cycle" EXACT []
synonym: "urea biosynthesis" EXACT []
synonym: "urea biosynthetic process" EXACT []
xref: Reactome:REACT_100599 "Urea cycle, Oryza sativa"
xref: Reactome:REACT_107747 "Urea cycle, Mus musculus"
xref: Reactome:REACT_109525 "Urea cycle, Danio rerio"
xref: Reactome:REACT_31787 "Urea cycle, Taeniopygia guttata"
xref: Reactome:REACT_32463 "Urea cycle, Drosophila melanogaster"
xref: Reactome:REACT_32971 "Urea cycle, Caenorhabditis elegans"
xref: Reactome:REACT_33119 "Urea cycle, Bos taurus"
xref: Reactome:REACT_78616 "Urea cycle, Plasmodium falciparum"
xref: Reactome:REACT_80089 "Urea cycle, Canis familiaris"
xref: Reactome:REACT_81058 "Urea cycle, Dictyostelium discoideum"
xref: Reactome:REACT_82995 "Urea cycle, Mycobacterium tuberculosis"
xref: Reactome:REACT_83831 "Urea cycle, Rattus norvegicus"
xref: Reactome:REACT_84694 "Urea cycle, Saccharomyces cerevisiae"
xref: Reactome:REACT_847 "Urea cycle, Homo sapiens"
xref: Reactome:REACT_88394 "Urea cycle, Gallus gallus"
xref: Reactome:REACT_90218 "Urea cycle, Escherichia coli"
xref: Reactome:REACT_90565 "Urea cycle, Sus scrofa"
xref: Reactome:REACT_92378 "Urea cycle, Xenopus tropicalis"
xref: Reactome:REACT_95880 "Urea cycle, Staphylococcus aureus N315"
xref: Reactome:REACT_97366 "Urea cycle, Arabidopsis thaliana"
xref: Reactome:REACT_98985 "Urea cycle, Schizosaccharomyces pombe"
xref: Wikipedia:Urea_cycle
is_a: GO:0019627 ! urea metabolic process
is_a: GO:0043604 ! amide biosynthetic process
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process

[Term]
id: GO:0000051
name: obsolete urea cycle intermediate metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving any of the intermediate compounds involved in the urea cycle, a cyclic metabolic pathway that converts waste nitrogen in the form of ammonium to urea." [GOC:jl, ISBN:0198506732]
comment: This term was made obsolete because it is a grouping term that is not useful, but has caused true path violations.
subset: gosubset_prok
synonym: "urea cycle intermediate metabolic process" EXACT []
synonym: "urea cycle intermediate metabolism" EXACT []
is_obsolete: true

[Term]
id: GO:0000052
name: citrulline metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins." [ISBN:0198506732]
subset: gosubset_prok
synonym: "citrulline metabolism" EXACT []
is_a: GO:0006575 ! cellular modified amino acid metabolic process
is_a: GO:1901605 ! alpha-amino acid metabolic process

[Term]
id: GO:0000053
name: argininosuccinate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving argininosuccinate, 2-(N(omega)-arginino)succinate, an intermediate in the ornithine-urea cycle, where it is synthesized from citrulline and aspartate." [ISBN:0198506732]
synonym: "argininosuccinate metabolism" EXACT []
is_a: GO:0006575 ! cellular modified amino acid metabolic process
is_a: GO:0072350 ! tricarboxylic acid metabolic process
is_a: GO:1901605 ! alpha-amino acid metabolic process

[Term]
id: GO:0000054
name: ribosomal subunit export from nucleus
namespace: biological_process
def: "The directed movement of a ribosomal subunit from the nucleus into the cytoplasm." [GOC:ai]
subset: goslim_yeast
synonym: "ribosomal subunit export from cell nucleus" EXACT [GOC:mah]
synonym: "ribosomal subunit export out of nucleus" EXACT [GOC:mah]
synonym: "ribosomal subunit transport from nucleus to cytoplasm" EXACT [GOC:mah]
synonym: "ribosomal subunit-nucleus export" EXACT [GOC:mah]
synonym: "ribosome export from nucleus" RELATED [GOC:mah, GOC:rb]
is_a: GO:0033753 ! establishment of ribosome localization
is_a: GO:0071428 ! rRNA-containing ribonucleoprotein complex export from nucleus
is_a: GO:1902580 ! single-organism cellular localization
relationship: part_of GO:0042254 ! ribosome biogenesis

[Term]
id: GO:0000055
name: ribosomal large subunit export from nucleus
namespace: biological_process
alt_id: GO:0000057
def: "The directed movement of a ribosomal large subunit from the nucleus into the cytoplasm." [GOC:mah]
synonym: "50S ribosomal subunit export from nucleus" NARROW [GOC:mah]
synonym: "60S ribosomal subunit export from nucleus" NARROW [GOC:mah]
synonym: "ribosomal large subunit export from cell nucleus" EXACT []
synonym: "ribosomal large subunit export out of nucleus" EXACT []
synonym: "ribosomal large subunit transport from nucleus to cytoplasm" EXACT []
synonym: "ribosomal large subunit-nucleus export" EXACT []
is_a: GO:0000054 ! ribosomal subunit export from nucleus

[Term]
id: GO:0000056
name: ribosomal small subunit export from nucleus
namespace: biological_process
alt_id: GO:0000058
def: "The directed movement of a ribosomal small subunit from the nucleus into the cytoplasm." [GOC:mah]
synonym: "30S ribosomal subunit export from nucleus" NARROW [GOC:mah]
synonym: "40S ribosomal subunit export from nucleus" NARROW [GOC:mah]
synonym: "ribosomal small subunit export from cell nucleus" EXACT []
synonym: "ribosomal small subunit export out of nucleus" EXACT []
synonym: "ribosomal small subunit transport from nucleus to cytoplasm" EXACT []
synonym: "ribosomal small subunit-nucleus export" EXACT []
is_a: GO:0000054 ! ribosomal subunit export from nucleus

[Term]
id: GO:0000059
name: protein import into nucleus, docking
namespace: biological_process
def: "A protein complex assembly process that contributes to protein import into the nucleus, and that results in the association of a cargo protein, a carrier protein such as an importin alpha/beta heterodimer, and a nucleoporin located at the periphery of the nuclear pore complex." [GOC:isa_complete, GOC:mah, PMID:14570049, PMID:7878057, PMID:9126736]
synonym: "protein docking during protein import into nucleus" EXACT []
synonym: "protein docking during protein transport from cytoplasm to nucleus" EXACT []
synonym: "protein docking during protein-nucleus import" EXACT []
synonym: "protein transport from cytoplasm to nucleus, docking" EXACT []
synonym: "protein-nucleus import, docking" EXACT []
is_a: GO:0043623 ! cellular protein complex assembly
relationship: part_of GO:0006606 ! protein import into nucleus

[Term]
id: GO:0000060
name: protein import into nucleus, translocation
namespace: biological_process
def: "A protein transport process that contributes to protein import into the nucleus, and that results in the vectorial transfer of a cargo-carrier protein complex through the nuclear pore complex from the cytoplasmic side to the nucleoplasmic side of the nuclear envelope." [GOC:curators, ISBN:0198506732, PMID:14570049, PMID:9126736]
comment: Note that 'vectorial' is used in the definition in the mathematical and physical sense of pertaining to 'a quantity having direction as well as magnitude, especially as determining the position of one point in space relative to another. Note that 'translocation' is sometimes used in the literature to refer to the entire process of protein import into the nucleus, but in GO refers specifically to the step in which a cargo-carrier protein complex moves through the nuclear pore complex.
synonym: "protein import into cell nucleus, translocation" EXACT []
synonym: "protein translocation during protein import into nucleus" EXACT []
synonym: "protein translocation during protein transport from cytoplasm to nucleus" EXACT []
synonym: "protein translocation during protein-nucleus import" EXACT []
synonym: "protein transport from cytoplasm to nucleus, translocation" EXACT []
synonym: "protein-nucleus import, translocation" EXACT []
is_a: GO:0006886 ! intracellular protein transport
is_a: GO:1902582 ! single-organism intracellular transport
relationship: part_of GO:0006606 ! protein import into nucleus

[Term]
id: GO:0000061
name: protein import into nucleus, substrate release
namespace: biological_process
def: "A protein complex disassembly process that contributes to protein import into the nucleus, and that results in the dissociation of the cargo protein and the carrier (such as an importin alpha/beta heterodimer) from each other and from the nuclear pore complex." [GOC:mah, PMID:14570049, PMID:9126736, PMID:9687515]
synonym: "protein import into cell nucleus, substrate release" EXACT []
synonym: "protein substrate release during protein import into nucleus" EXACT []
synonym: "protein substrate release during protein transport from cytoplasm to nucleus" EXACT []
synonym: "protein substrate release during protein-nucleus import" EXACT []
synonym: "protein transport from cytoplasm to nucleus, substrate release" EXACT []
synonym: "protein-nucleus import, substrate release" EXACT []
is_a: GO:0043624 ! cellular protein complex disassembly
relationship: part_of GO:0006606 ! protein import into nucleus

[Term]
id: GO:0000062
name: fatty-acyl-CoA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "acyl-CoA or acyl binding" BROAD []
is_a: GO:0043168 ! anion binding
is_a: GO:0050662 ! coenzyme binding
is_a: GO:1901681 ! sulfur compound binding

[Term]
id: GO:0000064
name: L-ornithine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of L-ornithine from one side of a membrane to the other. L-ornithine is 2,5-diaminopentanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "histidine/arginine/lysine/ornithine porter activity" RELATED []
synonym: "L-ornithine transporter activity" BROAD []
xref: Reactome:REACT_100602 "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic), Mus musculus"
xref: Reactome:REACT_102399 "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic), Xenopus tropicalis"
xref: Reactome:REACT_103552 "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic), Gallus gallus"
xref: Reactome:REACT_103610 "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic), Canis familiaris"
xref: Reactome:REACT_104169 "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic), Sus scrofa"
xref: Reactome:REACT_109285 "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic), Caenorhabditis elegans"
xref: Reactome:REACT_115531 "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic), Gallus gallus"
xref: Reactome:REACT_151 "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic), Homo sapiens"
xref: Reactome:REACT_28177 "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic), Drosophila melanogaster"
xref: Reactome:REACT_30708 "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic), Arabidopsis thaliana"
xref: Reactome:REACT_78308 "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic), Dictyostelium discoideum"
xref: Reactome:REACT_84383 "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic), Oryza sativa"
xref: Reactome:REACT_88886 "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic), Danio rerio"
xref: Reactome:REACT_88959 "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic), Rattus norvegicus"
xref: Reactome:REACT_90007 "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic), Taeniopygia guttata"
is_a: GO:0008324 ! cation transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity
relationship: part_of GO:1903352 ! L-ornithine transmembrane transport

[Term]
id: GO:0000066
name: mitochondrial ornithine transport
namespace: biological_process
def: "The directed movement of ornithine, 2,5-diaminopentanoic acid, into, out of or within a mitochondrion." [GOC:ai]
is_a: GO:0006839 ! mitochondrial transport
is_a: GO:0015822 ! ornithine transport

[Term]
id: GO:0000067
name: obsolete DNA replication and chromosome cycle
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it has been superseded by more accurate terms to represent the biological processes occurring, and it is not clear that this term represents a useful entity.
synonym: "DNA replication and chromosome cycle" EXACT []
is_obsolete: true
consider: GO:0006260
consider: GO:0007059
consider: GO:0051276

[Term]
id: GO:0000070
name: mitotic sister chromatid segregation
namespace: biological_process
alt_id: GO:0016359
def: "The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, GOC:jl]
synonym: "mitotic chromosome segregation" EXACT []
synonym: "mitotic sister-chromatid adhesion release" NARROW []
is_a: GO:0000819 ! sister chromatid segregation
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0098813 ! nuclear chromosome segregation
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0007067 ! mitotic nuclear division

[Term]
id: GO:0000072
name: obsolete M phase specific microtubule process
namespace: biological_process
def: "OBSOLETE. A microtubule-based process that occurs only during M phase of the cell cycle." [GOC:mah]
comment: This term was made obsolete because terms already exist for centrosome/spindle organization which would be more suitable for the existing annotations, and the phase could be captured as an annotation extension if necessary.
synonym: "M phase specific microtubule process" EXACT []
synonym: "M-phase specific microtubule process" EXACT []
is_obsolete: true
consider: GO:0007017

[Term]
id: GO:0000073
name: spindle pole body separation
namespace: biological_process
alt_id: GO:0030475
def: "A largely uncharacterized process involving the release of duplicated spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane. Duplicated SPBs are connected by a bridge structure that may be severed in order to release the SPBs from one another. Following liberation, SPBs diffuse through the nuclear membrane until they are across from each other. SPB separation must take place in order for a bipolar mitotic spindle to assemble." [GOC:sgd_curators]
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0051300 ! spindle pole body organization

[Term]
id: GO:0000075
name: cell cycle checkpoint
namespace: biological_process
alt_id: GO:0031576
alt_id: GO:0071779
def: "A cell cycle process that controls cell cycle progression by monitoring the integrity of specific cell cycle events. A cell cycle checkpoint begins with detection of deficiencies or defects and ends with signal transduction." [GOC:mtg_cell_cycle]
comment: This term should not be used in direct manual annotation as it should always be possible to minimally designate mitotic or meiotic checkpoint, and usually to additionally specify the checkpoint (i.e mitotic spindle assembly checkpoint, mitotic DNA damage checkpoint etc). Note also that the effector processes are not part of the checkpoint but are positively regulated by the checkpoint signaling and should not be annotated here.
subset: gocheck_do_not_manually_annotate
synonym: "G1/S checkpoint" NARROW []
synonym: "G1/S transition checkpoint" NARROW []
synonym: "G2/M checkpoint" NARROW []
synonym: "G2/M transition checkpoint" NARROW []
xref: Reactome:REACT_100401 "Cell Cycle Checkpoints, Gallus gallus"
xref: Reactome:REACT_102145 "Cell Cycle Checkpoints, Saccharomyces cerevisiae"
xref: Reactome:REACT_102175 "Cell Cycle Checkpoints, Canis familiaris"
xref: Reactome:REACT_106487 "Cell Cycle Checkpoints, Rattus norvegicus"
xref: Reactome:REACT_109101 "Cell Cycle Checkpoints, Drosophila melanogaster"
xref: Reactome:REACT_1538 "Cell Cycle Checkpoints, Homo sapiens"
xref: Reactome:REACT_29957 "Cell Cycle Checkpoints, Bos taurus"
xref: Reactome:REACT_31789 "Cell Cycle Checkpoints, Dictyostelium discoideum"
xref: Reactome:REACT_33305 "Cell Cycle Checkpoints, Oryza sativa"
xref: Reactome:REACT_79078 "Cell Cycle Checkpoints, Sus scrofa"
xref: Reactome:REACT_84460 "Cell Cycle Checkpoints, Arabidopsis thaliana"
xref: Reactome:REACT_89660 "Cell Cycle Checkpoints, Xenopus tropicalis"
xref: Reactome:REACT_90285 "Cell Cycle Checkpoints, Mus musculus"
xref: Reactome:REACT_90465 "Cell Cycle Checkpoints, Caenorhabditis elegans"
xref: Reactome:REACT_92239 "Cell Cycle Checkpoints, Danio rerio"
xref: Reactome:REACT_96499 "Cell Cycle Checkpoints, Taeniopygia guttata"
xref: Reactome:REACT_99737 "Cell Cycle Checkpoints, Schizosaccharomyces pombe"
xref: Wikipedia:Cell_cycle_checkpoint
is_a: GO:0022402 ! cell cycle process

[Term]
id: GO:0000076
name: DNA replication checkpoint
namespace: biological_process
def: "A cell cycle checkpoint that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome." [GOC:curators, GOC:rn, PMID:11728327, PMID:12537518]
is_a: GO:0031570 ! DNA integrity checkpoint

[Term]
id: GO:0000077
name: DNA damage checkpoint
namespace: biological_process
def: "A cell cycle checkpoint that regulates progression through the cell cycle in response to DNA damage. A DNA damage checkpoint may blocks cell cycle progression (in G1, G2 or metaphase) or slow the rate at which S phase proceeds." [GOC:mtg_cell_cycle]
synonym: "DNA damage response, signal transduction resulting in cell cycle arrest" NARROW []
xref: Wikipedia:DNA_damage_checkpoint
xref: Wikipedia:Postreplication_checkpoint
is_a: GO:0006974 ! cellular response to DNA damage stimulus
is_a: GO:0031570 ! DNA integrity checkpoint

[Term]
id: GO:0000078
name: obsolete cytokinesis after mitosis checkpoint
namespace: biological_process
def: "OBSOLETE. A mitotic cell cycle checkpoint that detects whether chromosome segregation is complete and negatively regulates cytokinesis following mitosis." [GOC:mtg_cell_cycle]
comment: The reason this term was made obsolete is that the two terms cytokinesis checkpoint (GO:0031565) and cytokinesis after mitosis (GO:0000078) were conflated in meaning.
synonym: "cell morphogenesis checkpoint" EXACT [GOC:dph, GOC:vw]
synonym: "cell shape checkpoint" EXACT []
is_obsolete: true
consider: GO:0044878
consider: GO:0044879

[Term]
id: GO:0000079
name: regulation of cyclin-dependent protein serine/threonine kinase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity." [GOC:go_curators, GOC:pr]
synonym: "regulation of CDK activity" EXACT []
synonym: "regulation of cyclin-dependent protein kinase activity" BROAD []
is_a: GO:0071900 ! regulation of protein serine/threonine kinase activity
is_a: GO:1904029 ! regulation of cyclin-dependent protein kinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004693 ! cyclin-dependent protein serine/threonine kinase activity
relationship: regulates GO:0004693 ! cyclin-dependent protein serine/threonine kinase activity

[Term]
id: GO:0000080
name: mitotic G1 phase
namespace: biological_process
def: "The cell cycle 'gap' phase which is the interval between the completion of DNA segregation by mitosis and the beginning of DNA synthesis." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "G1 phase of mitotic cell cycle" EXACT []
xref: Reactome:REACT_101162 "G1 Phase, Bos taurus"
xref: Reactome:REACT_1590 "G1 Phase, Homo sapiens"
xref: Reactome:REACT_29795 "G1 Phase, Taeniopygia guttata"
xref: Reactome:REACT_34060 "G1 Phase, Canis familiaris"
xref: Reactome:REACT_78665 "G1 Phase, Gallus gallus"
xref: Reactome:REACT_78866 "G1 Phase, Sus scrofa"
xref: Reactome:REACT_83686 "G1 Phase, Danio rerio"
xref: Reactome:REACT_91654 "G1 Phase, Mus musculus"
xref: Reactome:REACT_93384 "G1 Phase, Rattus norvegicus"
xref: Reactome:REACT_93574 "G1 Phase, Xenopus tropicalis"
is_a: GO:0051318 ! G1 phase
is_a: GO:0098763 ! mitotic cell cycle phase
relationship: part_of GO:0051329 ! mitotic interphase

[Term]
id: GO:0000082
name: G1/S transition of mitotic cell cycle
namespace: biological_process
def: "The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated." [GOC:mtg_cell_cycle]
xref: Reactome:REACT_101799 "G1/S Transition, Taeniopygia guttata"
xref: Reactome:REACT_102687 "G1/S Transition, Arabidopsis thaliana"
xref: Reactome:REACT_104020 "G1/S Transition, Canis familiaris"
xref: Reactome:REACT_104529 "G1/S Transition, Schizosaccharomyces pombe"
xref: Reactome:REACT_104577 "G1/S Transition, Saccharomyces cerevisiae"
xref: Reactome:REACT_106054 "G1/S Transition, Mus musculus"
xref: Reactome:REACT_107492 "G1/S Transition, Dictyostelium discoideum"
xref: Reactome:REACT_109784 "G1/S Transition, Oryza sativa"
xref: Reactome:REACT_109821 "G1/S Transition, Danio rerio"
xref: Reactome:REACT_110917 "G1/S Transition, Plasmodium falciparum"
xref: Reactome:REACT_1783 "G1/S Transition, Homo sapiens"
xref: Reactome:REACT_28713 "G1/S Transition, Xenopus tropicalis"
xref: Reactome:REACT_45711 "G1/S Transition, Caenorhabditis elegans"
xref: Reactome:REACT_84226 "G1/S Transition, Gallus gallus"
xref: Reactome:REACT_85355 "G1/S Transition, Sus scrofa"
xref: Reactome:REACT_87037 "G1/S Transition, Drosophila melanogaster"
xref: Reactome:REACT_88046 "G1/S Transition, Bos taurus"
xref: Reactome:REACT_95294 "G1/S Transition, Rattus norvegicus"
is_a: GO:0044772 ! mitotic cell cycle phase transition
is_a: GO:0044843 ! cell cycle G1/S phase transition

[Term]
id: GO:0000083
name: regulation of transcription involved in G1/S transition of mitotic cell cycle
namespace: biological_process
def: "Any process that regulates transcription such that the target genes are involved in the transition between G1 and S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle]
xref: Reactome:REACT_683 "G1/S-Specific Transcription, Homo sapiens"
is_a: GO:0006355 ! regulation of transcription, DNA-templated
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0006355 ! regulation of transcription, DNA-templated
intersection_of: part_of GO:0000082 ! G1/S transition of mitotic cell cycle
relationship: part_of GO:0000082 ! G1/S transition of mitotic cell cycle

[Term]
id: GO:0000084
name: mitotic S phase
namespace: biological_process
def: "The cell cycle phase, following G1, during which DNA synthesis takes place as part of a mitotic cell cycle." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "S phase of mitotic cell cycle" EXACT []
synonym: "S-phase of mitotic cell cycle" EXACT []
xref: Reactome:REACT_105829 "S Phase, Caenorhabditis elegans"
xref: Reactome:REACT_108550 "S Phase, Rattus norvegicus"
xref: Reactome:REACT_110039 "S Phase, Schizosaccharomyces pombe"
xref: Reactome:REACT_28988 "S Phase, Taeniopygia guttata"
xref: Reactome:REACT_32013 "S Phase, Mycobacterium tuberculosis"
xref: Reactome:REACT_34043 "S Phase, Oryza sativa"
xref: Reactome:REACT_78838 "S Phase, Plasmodium falciparum"
xref: Reactome:REACT_78845 "S Phase, Xenopus tropicalis"
xref: Reactome:REACT_81914 "S Phase, Saccharomyces cerevisiae"
xref: Reactome:REACT_82813 "S Phase, Arabidopsis thaliana"
xref: Reactome:REACT_85811 "S Phase, Sus scrofa"
xref: Reactome:REACT_89318 "S Phase, Drosophila melanogaster"
xref: Reactome:REACT_899 "S Phase, Homo sapiens"
xref: Reactome:REACT_92500 "S Phase, Mus musculus"
xref: Reactome:REACT_92759 "S Phase, Canis familiaris"
xref: Reactome:REACT_95174 "S Phase, Gallus gallus"
xref: Reactome:REACT_96081 "S Phase, Dictyostelium discoideum"
xref: Reactome:REACT_97603 "S Phase, Danio rerio"
xref: Reactome:REACT_99645 "S Phase, Bos taurus"
is_a: GO:0051320 ! S phase
is_a: GO:0098763 ! mitotic cell cycle phase
relationship: part_of GO:0051329 ! mitotic interphase

[Term]
id: GO:0000085
name: mitotic G2 phase
namespace: biological_process
def: "The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation by mitosis." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "G2 phase of mitotic cell cycle" EXACT []
xref: Reactome:REACT_105223 "G2 Phase, Mus musculus"
xref: Reactome:REACT_105307 "G2 Phase, Canis familiaris"
xref: Reactome:REACT_106415 "G2 Phase, Xenopus tropicalis"
xref: Reactome:REACT_106836 "G2 Phase, Bos taurus"
xref: Reactome:REACT_1915 "G2 Phase, Homo sapiens"
xref: Reactome:REACT_28975 "G2 Phase, Rattus norvegicus"
xref: Reactome:REACT_85928 "G2 Phase, Sus scrofa"
xref: Reactome:REACT_96332 "G2 Phase, Danio rerio"
is_a: GO:0051319 ! G2 phase
is_a: GO:0098763 ! mitotic cell cycle phase
relationship: part_of GO:0051329 ! mitotic interphase

[Term]
id: GO:0000086
name: G2/M transition of mitotic cell cycle
namespace: biological_process
def: "The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex." [GOC:mtg_cell_cycle]
synonym: "mitotic G2/M transition" EXACT []
xref: Reactome:REACT_100942 "G2/M Transition, Danio rerio"
xref: Reactome:REACT_103766 "G2/M Transition, Schizosaccharomyces pombe"
xref: Reactome:REACT_107882 "G2/M Transition, Sus scrofa"
xref: Reactome:REACT_114616 "G2/M Transition, Arabidopsis thaliana"
xref: Reactome:REACT_2203 "G2/M Transition, Homo sapiens"
xref: Reactome:REACT_28929 "G2/M Transition, Xenopus tropicalis"
xref: Reactome:REACT_30388 "G2/M Transition, Gallus gallus"
xref: Reactome:REACT_34062 "G2/M Transition, Mus musculus"
xref: Reactome:REACT_77778 "G2/M Transition, Taeniopygia guttata"
xref: Reactome:REACT_83880 "G2/M Transition, Drosophila melanogaster"
xref: Reactome:REACT_87036 "G2/M Transition, Saccharomyces cerevisiae"
xref: Reactome:REACT_87230 "G2/M Transition, Canis familiaris"
xref: Reactome:REACT_87807 "G2/M Transition, Dictyostelium discoideum"
xref: Reactome:REACT_88018 "G2/M Transition, Caenorhabditis elegans"
xref: Reactome:REACT_88369 "G2/M Transition, Rattus norvegicus"
xref: Reactome:REACT_92702 "G2/M Transition, Bos taurus"
is_a: GO:0044772 ! mitotic cell cycle phase transition
is_a: GO:0044839 ! cell cycle G2/M phase transition
intersection_of: GO:0044839 ! cell cycle G2/M phase transition
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0000087
name: mitotic M phase
namespace: biological_process
def: "A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a mitotic cell cycle." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "M phase of mitotic cell cycle" EXACT []
synonym: "M-phase of mitotic cell cycle" EXACT []
xref: Reactome:REACT_105412 "M Phase, Mus musculus"
xref: Reactome:REACT_107095 "M Phase, Dictyostelium discoideum"
xref: Reactome:REACT_109059 "M Phase, Saccharomyces cerevisiae"
xref: Reactome:REACT_29488 "M Phase, Canis familiaris"
xref: Reactome:REACT_33490 "M Phase, Caenorhabditis elegans"
xref: Reactome:REACT_82055 "M Phase, Rattus norvegicus"
xref: Reactome:REACT_87132 "M Phase, Bos taurus"
xref: Reactome:REACT_88263 "M Phase, Xenopus tropicalis"
xref: Reactome:REACT_910 "M Phase, Homo sapiens"
xref: Reactome:REACT_92998 "M Phase, Danio rerio"
xref: Reactome:REACT_93131 "M Phase, Schizosaccharomyces pombe"
xref: Reactome:REACT_93566 "M Phase, Gallus gallus"
xref: Reactome:REACT_93720 "M Phase, Drosophila melanogaster"
xref: Reactome:REACT_94536 "M Phase, Taeniopygia guttata"
is_a: GO:0000279 ! M phase
is_a: GO:0098763 ! mitotic cell cycle phase
intersection_of: GO:0000279 ! M phase
intersection_of: happens_during GO:0000278 ! mitotic cell cycle
relationship: happens_during GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0000088
name: mitotic prophase
namespace: biological_process
def: "The cell cycle phase which is the first stage of M phase of mitosis and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
xref: Reactome:REACT_100605 "Mitotic Prophase, Saccharomyces cerevisiae"
xref: Reactome:REACT_102122 "Mitotic Prophase, Mus musculus"
xref: Reactome:REACT_105127 "Mitotic Prophase, Danio rerio"
xref: Reactome:REACT_106058 "Mitotic Prophase, Drosophila melanogaster"
xref: Reactome:REACT_28443 "Mitotic Prophase, Taeniopygia guttata"
xref: Reactome:REACT_28607 "Mitotic Prophase, Rattus norvegicus"
xref: Reactome:REACT_32677 "Mitotic Prophase, Xenopus tropicalis"
xref: Reactome:REACT_765 "Mitotic Prophase, Homo sapiens"
xref: Reactome:REACT_79474 "Mitotic Prophase, Caenorhabditis elegans"
xref: Reactome:REACT_80300 "Mitotic Prophase, Gallus gallus"
xref: Reactome:REACT_83888 "Mitotic Prophase, Dictyostelium discoideum"
xref: Reactome:REACT_90347 "Mitotic Prophase, Canis familiaris"
xref: Reactome:REACT_90481 "Mitotic Prophase, Schizosaccharomyces pombe"
is_a: GO:0051324 ! prophase
is_a: GO:0098763 ! mitotic cell cycle phase
relationship: part_of GO:0000087 ! mitotic M phase

[Term]
id: GO:0000089
name: mitotic metaphase
namespace: biological_process
def: "The cell cycle phase, following prophase, during which chromosomes become aligned on the equatorial plate of the cell as part of a mitotic cell cycle." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
xref: Reactome:REACT_434 "Mitotic Metaphase, Homo sapiens"
is_a: GO:0051323 ! metaphase
is_a: GO:0098763 ! mitotic cell cycle phase
relationship: part_of GO:0000087 ! mitotic M phase

[Term]
id: GO:0000090
name: mitotic anaphase
namespace: biological_process
def: "The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of a mitotic cell cycle." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
xref: Reactome:REACT_1275 "Mitotic Anaphase, Homo sapiens"
is_a: GO:0051322 ! anaphase
is_a: GO:0098763 ! mitotic cell cycle phase
relationship: part_of GO:0000087 ! mitotic M phase

[Term]
id: GO:0000091
name: mitotic anaphase A
namespace: biological_process
def: "The cell cycle phase during which the kinetochore microtubules shorten as chromosomes move toward the spindle poles as part of mitosis." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0000090 ! mitotic anaphase

[Term]
id: GO:0000092
name: mitotic anaphase B
namespace: biological_process
def: "The cell cycle phase during which the polar microtubules elongate and the two poles of the spindle move farther apart as part of mitosis." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0000090 ! mitotic anaphase

[Term]
id: GO:0000093
name: mitotic telophase
namespace: biological_process
def: "The cell cycle phase which follows anaphase during M phase of mitosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0051326 ! telophase
is_a: GO:0098763 ! mitotic cell cycle phase
relationship: part_of GO:0000087 ! mitotic M phase

[Term]
id: GO:0000094
name: obsolete septin assembly and septum formation
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it was not defined and the string name implied two separate processes.
synonym: "septin assembly and septum formation" EXACT []
is_obsolete: true
consider: GO:0000917
consider: GO:0000918
consider: GO:0000921

[Term]
id: GO:0000095
name: S-adenosyl-L-methionine transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015177
def: "Enables the transfer of S-adenosylmethionine from one side of a membrane to the other. S-adenosylmethionine is S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism." [GOC:ai]
synonym: "S-adenosyl methionine permease activity" EXACT []
synonym: "S-adenosyl methionine transporter activity" EXACT []
synonym: "S-adenosylmethionine permease activity" EXACT []
synonym: "S-adenosylmethionine transmembrane transporter activity" EXACT []
synonym: "S-adenosylmethionine transporter activity" BROAD []
synonym: "SAM transmembrane transporter activity" EXACT []
is_a: GO:0015211 ! purine nucleoside transmembrane transporter activity
is_a: GO:0051185 ! coenzyme transporter activity
is_a: GO:0072349 ! modified amino acid transmembrane transporter activity
is_a: GO:1901682 ! sulfur compound transmembrane transporter activity
relationship: part_of GO:1901962 ! S-adenosyl-L-methionine transmembrane transport

[Term]
id: GO:0000096
name: sulfur amino acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine." [GOC:ai]
subset: gosubset_prok
synonym: "sulfur amino acid metabolism" EXACT []
synonym: "sulphur amino acid metabolic process" EXACT []
synonym: "sulphur amino acid metabolism" EXACT []
xref: Reactome:REACT_115639 "Sulfur amino acid metabolism, Homo sapiens"
xref: Reactome:REACT_118084 "Sulfur amino acid metabolism, Rattus norvegicus"
xref: Reactome:REACT_118094 "Sulfur amino acid metabolism, Bos taurus"
xref: Reactome:REACT_118099 "Sulfur amino acid metabolism, Escherichia coli"
xref: Reactome:REACT_118166 "Sulfur amino acid metabolism, Taeniopygia guttata"
xref: Reactome:REACT_118184 "Sulfur amino acid metabolism, Canis familiaris"
xref: Reactome:REACT_118203 "Sulfur amino acid metabolism, Sus scrofa"
xref: Reactome:REACT_118227 "Sulfur amino acid metabolism, Mycobacterium tuberculosis"
xref: Reactome:REACT_118256 "Sulfur amino acid metabolism, Staphylococcus aureus N315"
xref: Reactome:REACT_118291 "Sulfur amino acid metabolism, Caenorhabditis elegans"
xref: Reactome:REACT_118309 "Sulfur amino acid metabolism, Gallus gallus"
xref: Reactome:REACT_118314 "Sulfur amino acid metabolism, Arabidopsis thaliana"
xref: Reactome:REACT_118323 "Sulfur amino acid metabolism, Xenopus tropicalis"
xref: Reactome:REACT_118328 "Sulfur amino acid metabolism, Drosophila melanogaster"
xref: Reactome:REACT_118349 "Sulfur amino acid metabolism, Oryza sativa"
xref: Reactome:REACT_118370 "Sulfur amino acid metabolism, Mus musculus"
xref: Reactome:REACT_118388 "Sulfur amino acid metabolism, Saccharomyces cerevisiae"
xref: Reactome:REACT_118463 "Sulfur amino acid metabolism, Schizosaccharomyces pombe"
xref: Reactome:REACT_118518 "Sulfur amino acid metabolism, Dictyostelium discoideum"
xref: Reactome:REACT_118541 "Sulfur amino acid metabolism, Danio rerio"
xref: Reactome:REACT_27187 "Sulfur amino acid metabolism, Mycobacterium tuberculosis"
is_a: GO:0006520 ! cellular amino acid metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process

[Term]
id: GO:0000097
name: sulfur amino acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine." [GOC:ai]
subset: gosubset_prok
synonym: "sulfur amino acid anabolism" EXACT []
synonym: "sulfur amino acid biosynthesis" EXACT []
synonym: "sulfur amino acid formation" EXACT []
synonym: "sulfur amino acid synthesis" EXACT []
synonym: "sulphur amino acid biosynthesis" EXACT []
synonym: "sulphur amino acid biosynthetic process" EXACT []
is_a: GO:0000096 ! sulfur amino acid metabolic process
is_a: GO:0008652 ! cellular amino acid biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process

[Term]
id: GO:0000098
name: sulfur amino acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine." [GOC:ai]
subset: gosubset_prok
synonym: "sulfur amino acid breakdown" EXACT []
synonym: "sulfur amino acid catabolism" EXACT []
synonym: "sulfur amino acid degradation" EXACT []
synonym: "sulphur amino acid catabolic process" EXACT []
synonym: "sulphur amino acid catabolism" EXACT []
xref: Reactome:REACT_115654 "Degradation of cysteine and homocysteine, Homo sapiens"
is_a: GO:0000096 ! sulfur amino acid metabolic process
is_a: GO:0009063 ! cellular amino acid catabolic process
is_a: GO:0044273 ! sulfur compound catabolic process

[Term]
id: GO:0000099
name: sulfur amino acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of sulfur amino acids from one side of a membrane to the other. Sulphur amino acids contain sulfur in the form of cystine, methionine or their derivatives." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "sulfur amino acid transporter activity" BROAD []
synonym: "sulphur amino acid transmembrane transporter activity" EXACT []
synonym: "sulphur amino acid transporter activity" BROAD []
is_a: GO:0015171 ! amino acid transmembrane transporter activity
is_a: GO:1901682 ! sulfur compound transmembrane transporter activity

[Term]
id: GO:0000100
name: S-methylmethionine transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015178
def: "Catalysis of the transfer of S-methylmethionine from one side of a membrane to the other." [GOC:ai]
subset: gosubset_prok
synonym: "S-methylmethionine permease activity" EXACT []
synonym: "S-methylmethionine transporter activity" BROAD []
is_a: GO:0000099 ! sulfur amino acid transmembrane transporter activity
is_a: GO:0072349 ! modified amino acid transmembrane transporter activity
relationship: part_of GO:0015806 ! S-methylmethionine transport

[Term]
id: GO:0000101
name: sulfur amino acid transport
namespace: biological_process
def: "The directed movement of amino acids containing sulfur (cystine, methionine and their derivatives) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "sulphur amino acid transport" EXACT []
is_a: GO:0006865 ! amino acid transport
is_a: GO:0072348 ! sulfur compound transport

[Term]
id: GO:0000102
name: L-methionine secondary active transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of L-methionine from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport]
synonym: "L-methionine porter activity" RELATED []
is_a: GO:0005294 ! neutral L-amino acid secondary active transmembrane transporter activity
is_a: GO:0015191 ! L-methionine transmembrane transporter activity
is_a: GO:1901680 ! sulfur-containing amino acid secondary active transmembrane transporter activity

[Term]
id: GO:0000103
name: sulfate assimilation
namespace: biological_process
alt_id: GO:0019378
def: "The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds." [GOC:jl]
subset: gosubset_prok
synonym: "sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor" NARROW []
synonym: "sulphate assimilation" EXACT []
synonym: "sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor" NARROW []
xref: Reactome:REACT_27155 "Sulfate assimilation, Mycobacterium tuberculosis"
is_a: GO:0006790 ! sulfur compound metabolic process

[Term]
id: GO:0000104
name: succinate dehydrogenase activity
namespace: molecular_function
alt_id: GO:0019739
def: "Catalysis of the reaction: succinate + acceptor = fumarate + reduced acceptor." [EC:1.3.99.1, GOC:kd]
subset: gosubset_prok
synonym: "fumarate dehydrogenase activity" EXACT [EC:1.3.99.1]
synonym: "fumarate reductase activity" EXACT [EC:1.3.99.1]
synonym: "fumaric hydrogenase activity" EXACT [EC:1.3.99.1]
synonym: "succinate oxidoreductase activity" EXACT [EC:1.3.99.1]
synonym: "succinate:(acceptor) oxidoreductase activity" EXACT [EC:1.3.99.1]
synonym: "succinate:acceptor oxidoreductase activity" EXACT [EC:1.3.99.1]
synonym: "succinic acid dehydrogenase activity" EXACT [EC:1.3.99.1]
synonym: "succinic dehydrogenase activity" BROAD [EC:1.3.99.1]
synonym: "succinodehydrogenase activity" EXACT [EC:1.3.99.1]
synonym: "succinyl dehydrogenase activity" EXACT [EC:1.3.99.1]
xref: EC:1.3.99.1
xref: MetaCyc:SUCC-FUM-OXRED-RXN
xref: RHEA:16360
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0000105
name: histidine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "histidine anabolism" EXACT []
synonym: "histidine biosynthesis" EXACT []
synonym: "histidine formation" EXACT []
synonym: "histidine synthesis" EXACT []
xref: MetaCyc:HISTSYN-PWY
is_a: GO:0006547 ! histidine metabolic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901607 ! alpha-amino acid biosynthetic process

[Term]
id: GO:0000107
name: imidazoleglycerol-phosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + aminoimidazole carboxamide ribonucleotide + L-glutamate + 2 H(+)." [MetaCyc:GLUTAMIDOTRANS-RXN]
subset: gosubset_prok
synonym: "glutamine amidotransferase:cyclase activity" BROAD []
synonym: "imidazole glycerol phosphate synthase activity" EXACT []
synonym: "imidazole-glycerol-phosphate synthase activity" RELATED []
synonym: "imidazoleglycerol phosphate synthase activity" EXACT []
xref: EC:2.4.2.-
xref: MetaCyc:GLUTAMIDOTRANS-RXN
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0000108
name: obsolete repairosome
namespace: cellular_component
def: "OBSOLETE. A stable complex of proteins that carry out the DNA damage recognition and incision reactions characteristic of nucleotide excision repair (NER), such as DNA damage recognition, DNA helix unwinding, and endonucleolytic cleavage at sites flanking damaged DNA; includes TFIIH subunits and additional polypeptides; may form in the absence of DNA damage." [PMID:10681587, PMID:9852079]
comment: This term was made obsolete because 'repairosome' has fallen out of use in the literature, and the large complex described in the definition has not been confirmed to exist. The term has also confused annotators.
synonym: "repairosome" EXACT []
is_obsolete: true
replaced_by: GO:0000109

[Term]
id: GO:0000109
name: nucleotide-excision repair complex
namespace: cellular_component
def: "Any complex formed of proteins that act in nucleotide-excision repair." [PMID:10915862]
comment: Note that process information is included in the term and definition for the purpose of describing and distinguishing the complex.
subset: goslim_pir
synonym: "UvrB-UvrC complex" NARROW [PMID:12145219]
synonym: "UvrBC complex" NARROW [GOC:bm, PMID:12145219]
is_a: GO:0044428 ! nuclear part
is_a: GO:1990391 ! DNA repair complex

[Term]
id: GO:0000110
name: nucleotide-excision repair factor 1 complex
namespace: cellular_component
def: "One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and endodeoxynuclease activities. In S. cerevisiae, it is composed of Rad1p, Rad10p, and Rad14p; in human the subunits are ERCC4/XPF, ERCC1 and XPA, respectively." [PMID:10915862]
comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex.
synonym: "NEF1 complex" EXACT []
synonym: "XPA-ERCC1-ERCC4 complex" EXACT [PMID:8197175]
is_a: GO:0000109 ! nucleotide-excision repair complex

[Term]
id: GO:0000111
name: nucleotide-excision repair factor 2 complex
namespace: cellular_component
def: "One of several protein complexes involved in nucleotide-excision repair; possesses damaged DNA binding activity. In S. cerevisiae, it is composed of Rad4p and Rad23p." [PMID:10915862]
comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex.
synonym: "NEF2 complex" EXACT []
is_a: GO:0000109 ! nucleotide-excision repair complex

[Term]
id: GO:0000112
name: nucleotide-excision repair factor 3 complex
namespace: cellular_component
def: "One of several protein complexes involved in nucleotide-excision repair; possesses endodeoxynuclease and DNA helicase activities. In S. cerevisiae, it is composed of Rad2p and the core TFIIH-Ssl2p complex (core TFIIH is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p, Tfb4p and Tfb5p. Note that Ssl2p is also called Rad25p)." [GOC:ew, PMID:10915862, PMID:14500720, PMID:7813015]
comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex.
synonym: "NEF3 complex" EXACT []
is_a: GO:0000109 ! nucleotide-excision repair complex
relationship: has_part GO:0000439 ! core TFIIH complex

[Term]
id: GO:0000113
name: nucleotide-excision repair factor 4 complex
namespace: cellular_component
def: "One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and DNA-dependent ATPase activities. In S. cerevisiae, it is composed of Rad7p and Rad16p." [PMID:10915862]
comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex.
synonym: "NEF4 complex" EXACT []
is_a: GO:0000109 ! nucleotide-excision repair complex

[Term]
id: GO:0000114
name: obsolete regulation of transcription involved in G1 phase of mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that regulates transcription such that the target genes are transcribed as part of the G1 phase of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb]
comment: This term was made obsolete because it is unclear exactly what it means. It could mean either 'regulation of transcription during phase X' or 'regulation of transition between phase X and phase Y'.
synonym: "G1-specific transcription in mitotic cell cycle" RELATED []
synonym: "regulation of transcription from RNA polymerase II promoter during G1 phase of cell cycle" EXACT []
synonym: "regulation of transcription involved in G1 phase of mitotic cell cycle" EXACT []
is_obsolete: true
consider: GO:0000083

[Term]
id: GO:0000115
name: obsolete regulation of transcription involved in S phase of mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. A cell cycle process that regulates transcription such that the target genes are transcribed as part of the S phase of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb]
comment: This term was made obsolete because it is unclear exactly what it means. It could mean either 'regulation of transcription during phase X' or 'regulation of transition between phase X and phase Y'.
synonym: "regulation of transcription from RNA polymerase II promoter during S-phase of mitotic cell cycle" RELATED []
synonym: "regulation of transcription involved in S phase of mitotic cell cycle" EXACT []
synonym: "regulation of transcription involved in S-phase of mitotic cell cycle" EXACT []
synonym: "S-phase-specific transcription in mitotic cell cycle" RELATED []
synonym: "S-specific transcription in mitotic cell cycle" EXACT []
is_obsolete: true

[Term]
id: GO:0000116
name: obsolete regulation of transcription involved in G2-phase of mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that regulates transcription such that the target genes are transcribed as part of the G2 phase of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb]
comment: This term was made obsolete because it is unclear exactly what it means. It could mean either 'regulation of transcription during phase X' or 'regulation of transition between phase X and phase Y'.
synonym: "G2-specific transcription in mitotic cell cycle" RELATED []
synonym: "regulation of transcription from RNA polymerase II during G2-phase of mitotic cell cycle" RELATED []
synonym: "regulation of transcription involved in G2-phase of mitotic cell cycle" EXACT []
is_obsolete: true
consider: GO:0000117

[Term]
id: GO:0000117
name: regulation of transcription involved in G2/M transition of mitotic cell cycle
namespace: biological_process
def: "Any process that regulates transcription such that the target genes are transcribed as part of the G2/M transition of the mitotic cell cycle." [GOC:mtg_cell_cycle]
synonym: "G2/M-specific transcription in mitotic cell cycle" RELATED []
synonym: "regulation of transcription from RNA polymerase II promoter during G2/M transition of mitotic cell cycle" RELATED []
is_a: GO:0006355 ! regulation of transcription, DNA-templated
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0006355 ! regulation of transcription, DNA-templated
intersection_of: part_of GO:0000086 ! G2/M transition of mitotic cell cycle
relationship: part_of GO:0000086 ! G2/M transition of mitotic cell cycle

[Term]
id: GO:0000118
name: histone deacetylase complex
namespace: cellular_component
def: "A protein complex that possesses histone deacetylase activity." [GOC:mah]
comment: Note that this term represents a location, not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function of this complex is represented by the molecular function term 'histone deacetylase activity ; GO:0004407'.
synonym: "HDAC complex" EXACT []
is_a: GO:0044451 ! nucleoplasm part
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0000120
name: RNA polymerase I transcription factor complex
namespace: cellular_component
def: "A transcription factor complex that acts at promoters of genes transcribed by RNA polymerase I." [GOC:mah]
is_a: GO:0044452 ! nucleolar part
is_a: GO:0044798 ! nuclear transcription factor complex

[Term]
id: GO:0000121
name: glycerol-1-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycerol-1-phosphate + H2O = glycerol + phosphate." [EC:3.1.3.21]
synonym: "alpha-glycerol phosphatase activity" EXACT [EC:3.1.3.21]
synonym: "alpha-glycerophosphatase activity" EXACT [EC:3.1.3.21]
synonym: "glycerol 3-phosphatase activity" EXACT [EC:3.1.3.21]
synonym: "glycerol 3-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.21]
synonym: "glycerol-1-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.21]
synonym: "glycerol-3-phosphate phosphatase activity" EXACT [EC:3.1.3.21]
xref: EC:3.1.3.21
xref: MetaCyc:GLYCEROL-1-PHOSPHATASE-RXN
xref: RHEA:11479
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0000122
name: negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
alt_id: GO:0010553
alt_id: GO:0045816
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
synonym: "down regulation of global transcription from RNA polymerase II promoter" RELATED []
synonym: "down regulation of transcription from RNA polymerase II promoter" EXACT []
synonym: "down-regulation of global transcription from RNA polymerase II promoter" RELATED []
synonym: "down-regulation of transcription from RNA polymerase II promoter" EXACT []
synonym: "downregulation of global transcription from RNA polymerase II promoter" RELATED []
synonym: "downregulation of transcription from RNA polymerase II promoter" EXACT []
synonym: "inhibition of global transcription from RNA polymerase II promoter" RELATED []
synonym: "inhibition of transcription from RNA polymerase II promoter" EXACT []
synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter" RELATED []
synonym: "negative regulation of global transcription from Pol II promoter" RELATED []
synonym: "negative regulation of transcription from Pol II promoter" EXACT []
synonym: "negative regulation of transcription from RNA polymerase II promoter, global" RELATED []
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0045892 ! negative regulation of transcription, DNA-templated
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006366 ! transcription from RNA polymerase II promoter
relationship: negatively_regulates GO:0006366 ! transcription from RNA polymerase II promoter

[Term]
id: GO:0000123
name: histone acetyltransferase complex
namespace: cellular_component
def: "A protein complex that possesses histone acetyltransferase activity." [GOC:mah]
comment: Note that this term represents a location, not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function of this complex is represented by the molecular function term 'histone acetyltransferase activity ; GO:0004402'.
synonym: "histone acetylase complex" EXACT []
is_a: GO:0031248 ! protein acetyltransferase complex
is_a: GO:0044451 ! nucleoplasm part

[Term]
id: GO:0000124
name: SAGA complex
namespace: cellular_component
def: "A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery." [PMID:10637607, PMID:17337012]
synonym: "Spt-Ada-Gcn5-acetyltransferase complex" EXACT []
is_a: GO:0070461 ! SAGA-type complex
relationship: has_part GO:0071819 ! DUBm complex

[Term]
id: GO:0000125
name: PCAF complex
namespace: cellular_component
def: "A large multiprotein complex that possesses histone acetyltransferase activity and is involved in regulation of transcription. The composition is similar to that of the SAGA complex, but includes fewer Spt and Ada proteins, and more TAFs." [PMID:10637607]
comment: See also the cellular component term 'SAGA complex ; GO:0000124'.
synonym: "PCAF histone acetylase-associated complex" EXACT []
synonym: "SPT3-TAF9-PCAF acetylase complex" EXACT [GOC:rl, PMID:18838386]
is_a: GO:0070461 ! SAGA-type complex

[Term]
id: GO:0000126
name: transcription factor TFIIIB complex
namespace: cellular_component
def: "A transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIB contains the TATA-binding protein (TBP) and two Pol III-specific proteins, B'' and BRF." [GOC:mah, PMID:11433012]
is_a: GO:0090576 ! RNA polymerase III transcription factor complex

[Term]
id: GO:0000127
name: transcription factor TFIIIC complex
namespace: cellular_component
def: "A heterotrimeric transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIC contains three conserved subunits that associate with the proximal Pol III promoter element, and additional subunits that associate with sequence elements downstream of the promoter and are more diverged among species. It also functions as a boundary element to partition genome content into distinct domains outside Pol III promoter regions." [GOC:mah, GOC:vw, PMID:11433012, PMID:16751097]
is_a: GO:0090576 ! RNA polymerase III transcription factor complex

[Term]
id: GO:0000128
name: flocculation
namespace: biological_process
def: "The reversible, non-sexual aggregation of single-celled organisms in suspension to form aggregates of many cells known as flocs." [GOC:jl, GOC:vw, PMID:21114594, PMID:8740415]
comment: The word floc derives from the Latin word floccus, which means a tuft of wool.
subset: goslim_pir
subset: gosubset_prok
xref: Wikipedia:Flocculation
is_a: GO:0098630 ! aggregation of unicellular organisms

[Term]
id: GO:0000131
name: incipient cellular bud site
namespace: cellular_component
def: "The portion of the budding yeast plasma membrane where a daughter cell will emerge. The yeast marks this spot with bud-site selection proteins before bud emergence occurs. Actin is polarized to this spot just prior to and during bud emergence." [GOC:clt]
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0000132
name: establishment of mitotic spindle orientation
namespace: biological_process
alt_id: GO:0030607
alt_id: GO:0030609
def: "A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures." [GOC:ems]
synonym: "establishment of spindle orientation during mitosis" RELATED [GOC:dph, GOC:tb]
synonym: "establishment of spindle orientation involved in mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
synonym: "mitotic spindle orientation" EXACT []
synonym: "orienting of mitotic spindle" EXACT []
is_a: GO:0040001 ! establishment of mitotic spindle localization
is_a: GO:0051294 ! establishment of spindle orientation
intersection_of: GO:0051294 ! establishment of spindle orientation
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0000133
name: polarisome
namespace: cellular_component
def: "Protein complex that plays a role in determining cell polarity by directing the localized assembly of actin filaments at polarization sites; in Saccharomyces the polarisome includes Bni1p, Spa2p, Pea2p, and Bud6p." [PMID:14734532, PMID:14998522, PMID:9632790]
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044448 ! cell cortex part
relationship: part_of GO:0030427 ! site of polarized growth

[Term]
id: GO:0000136
name: alpha-1,6-mannosyltransferase complex
namespace: cellular_component
def: "A large, multiprotein complex with alpha-(1->6)-mannosyltransferase activity, located in the cis Golgi membrane; adds mannan to N-linked glycans on proteins." [GOC:mcc, PMID:10037752, PMID:11095735, PMID:18083825]
is_a: GO:0031501 ! mannosyltransferase complex
is_a: GO:0044431 ! Golgi apparatus part
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0000137 ! Golgi cis cisterna
relationship: part_of GO:0030173 ! integral component of Golgi membrane

[Term]
id: GO:0000137
name: Golgi cis cisterna
namespace: cellular_component
def: "The Golgi cisterna closest to the endoplasmic reticulum; the first processing compartment through which proteins pass after export from the ER." [ISBN:0815316194]
is_a: GO:0031985 ! Golgi cisterna

[Term]
id: GO:0000138
name: Golgi trans cisterna
namespace: cellular_component
def: "The Golgi cisterna farthest from the endoplasmic reticulum; the final processing compartment through which proteins pass before exiting the Golgi apparatus; the compartment in which N-linked protein glycosylation is completed." [ISBN:0815316194]
synonym: "late Golgi" RELATED [GOC:mah]
is_a: GO:0031985 ! Golgi cisterna

[Term]
id: GO:0000139
name: Golgi membrane
namespace: cellular_component
def: "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
is_a: GO:0044431 ! Golgi apparatus part
is_a: GO:0098588 ! bounding membrane of organelle

[Term]
id: GO:0000140
name: acylglycerone-phosphate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-palmitoylglycerol-3-phosphate + NADP+ = palmitoylglycerone phosphate + NADPH + H(+)." [EC:1.1.1.101]
synonym: "1-acyldihydroxyacetone-phosphate reductase activity" EXACT []
synonym: "1-palmitoylglycerol-3-phosphate:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.101]
synonym: "acyldihydroxyacetone phosphate reductase activity" EXACT [EC:1.1.1.101]
synonym: "palmitoyl dihydroxyacetone phosphate reductase activity" EXACT [EC:1.1.1.101]
synonym: "palmitoyl-dihydroxyacetone-phosphate reductase activity" EXACT [EC:1.1.1.101]
synonym: "palmitoyldihydroxyacetone-phosphate reductase activity" EXACT [EC:1.1.1.101]
xref: EC:1.1.1.101
xref: MetaCyc:ACYLGLYCERONE-PHOSPHATE-REDUCTASE-RXN
xref: Reactome:REACT_759 "O-hexadecylglycerone phosphate + NADPH + H+ => 1-hexadecyl glycerol-3-phosphate + NADP+, Homo sapiens"
xref: RHEA:17344
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0000142
name: cellular bud neck contractile ring
namespace: cellular_component
def: "A contractile ring, i.e. a cytoskeletal structure composed of actin filaments and myosin, that forms beneath the plasma membrane at the mother-bud neck in mitotic cells that divide by budding in preparation for completing cytokinesis. An example of this structure is found in Saccharomyces cerevisiae." [GOC:krc, PMID:16009555]
synonym: "neck ring" EXACT []
is_a: GO:0005826 ! actomyosin contractile ring
intersection_of: GO:0005826 ! actomyosin contractile ring
intersection_of: part_of GO:0005935 ! cellular bud neck
relationship: part_of GO:0005935 ! cellular bud neck

[Term]
id: GO:0000144
name: cellular bud neck septin ring
namespace: cellular_component
def: "A ring-shaped structure that forms at the site of cytokinesis in the bud neck of a budding cell; composed of members of the conserved family of filament forming proteins called septins as well as septin-associated proteins. In S. cerevisiae, this structure forms at the time of bud emergence and the septins show a high rate of exchange." [GOC:krc, PMID:16009555]
is_a: GO:0000399 ! cellular bud neck septin structure
is_a: GO:0005940 ! septin ring
is_a: GO:0032161 ! cleavage apparatus septin structure
intersection_of: GO:0005940 ! septin ring
intersection_of: part_of GO:0005935 ! cellular bud neck
relationship: part_of GO:0005935 ! cellular bud neck

[Term]
id: GO:0000145
name: exocyst
namespace: cellular_component
def: "A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals." [PMID:9700152]
synonym: "Sec6/8 complex" EXACT []
xref: Wikipedia:Exocyst
is_a: GO:0043234 ! protein complex
is_a: GO:0044448 ! cell cortex part

[Term]
id: GO:0000146
name: microfilament motor activity
namespace: molecular_function
def: "Catalysis of movement along a microfilament, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
synonym: "actin filament motor activity" EXACT [GOC:dph]
synonym: "actin-filament motor activity" EXACT []
synonym: "muscle motor activity" NARROW []
synonym: "myosin ATPase activity" RELATED []
xref: Reactome:REACT_15541 "Traversal of the cortical actin network and docking at plasma membrane, Homo sapiens"
xref: Reactome:REACT_20539 "Traversal of the cortical actin network., Mus musculus"
is_a: GO:0003774 ! motor activity

[Term]
id: GO:0000147
name: actin cortical patch assembly
namespace: biological_process
def: "Assembly of an actin cortical patch, a discrete actin-containing structure found at the plasma membrane of fungal cells." [GOC:mah]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0030866 ! cortical actin cytoskeleton organization
is_a: GO:0044396 ! actin cortical patch organization

[Term]
id: GO:0000148
name: 1,3-beta-D-glucan synthase complex
namespace: cellular_component
def: "A protein complex that catalyzes the transfer of a glucose group from UDP-glucose to a (1->3)-beta-D-glucan chain." [EC:2.4.1.34]
synonym: "(1->3)-beta-glucan synthase complex" EXACT [GOC:tb]
synonym: "1,3-beta-glucan synthase complex" EXACT [GOC:tb]
is_a: GO:0098797 ! plasma membrane protein complex
is_a: GO:1990234 ! transferase complex

[Term]
id: GO:0000149
name: SNARE binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein." [PMID:12642621]
subset: goslim_chembl
synonym: "SNAP receptor binding" EXACT []
xref: Reactome:REACT_100180 "Acetylcholine synaptic vesicle docking and priming, Rattus norvegicus"
xref: Reactome:REACT_101078 "Noradrenalin synaptic vesicle docking and priming, Canis familiaris"
xref: Reactome:REACT_103740 "Acetylcholine synaptic vesicle docking and priming, Canis familiaris"
xref: Reactome:REACT_105540 "Vamp7 associated Lysosome to Plasma membrane transport, Mus musculus"
xref: Reactome:REACT_106347 "release of L-Glutamate at the synapse, Canis familiaris"
xref: Reactome:REACT_107235 "Vamp2 associated secretory vesicle to plasma membrane transport, Dictyostelium discoideum"
xref: Reactome:REACT_107965 "Noradrenalin synaptic vesicle docking and priming, Mus musculus"
xref: Reactome:REACT_109894 "Vamp7 associated Lysosome to Plasma membrane transport, Dictyostelium discoideum"
xref: Reactome:REACT_110250 "Vamp2 associated secretory vesicle to plasma membrane transport, Canis familiaris"
xref: Reactome:REACT_110371 "Release of noradrenaline at the synapse, Rattus norvegicus"
xref: Reactome:REACT_110396 "Vamp7 associated Lysosome to Plasma membrane transport, Xenopus tropicalis"
xref: Reactome:REACT_112169 "Acetylcholine synaptic vesicle docking and priming, Caenorhabditis elegans"
xref: Reactome:REACT_112728 "Release of noradrenaline at the synapse, Caenorhabditis elegans"
xref: Reactome:REACT_113606 "Glutamate synaptic vesicle docking and priming, Caenorhabditis elegans"
xref: Reactome:REACT_113753 "Exocytosis of Insulin, Danio rerio"
xref: Reactome:REACT_114225 "Noradrenalin synaptic vesicle docking and priming, Gallus gallus"
xref: Reactome:REACT_114547 "Noradrenalin synaptic vesicle docking and priming, Caenorhabditis elegans"
xref: Reactome:REACT_115054 "release of L-Glutamate at the synapse, Xenopus tropicalis"
xref: Reactome:REACT_115130 "Acetylcholine synaptic vesicle docking and priming, Gallus gallus"
xref: Reactome:REACT_115353 "Release of acetylcholine at the synapse, Xenopus tropicalis"
xref: Reactome:REACT_12411 "release of L-Glutamate at the synapse, Homo sapiens"
xref: Reactome:REACT_12617 "Glutamate synaptic vesicle docking and priming, Homo sapiens"
xref: Reactome:REACT_14778 "Vamp7 associated Lysosome to Plasma membrane transport, Homo sapiens"
xref: Reactome:REACT_14821 "Vamp8 associated secretory vesicle to plasma membrane transport, Homo sapiens"
xref: Reactome:REACT_14822 "Vamp2 associated secretory vesicle to plasma membrane transport, Homo sapiens"
xref: Reactome:REACT_15326 "Exocytosis of Insulin, Homo sapiens"
xref: Reactome:REACT_15338 "Serotonin loaded synaptic vesicle docking and priming, Homo sapiens"
xref: Reactome:REACT_15404 "Release of acetylcholine at the synapse, Homo sapiens"
xref: Reactome:REACT_15411 "Noradrenalin synaptic vesicle docking and priming, Homo sapiens"
xref: Reactome:REACT_15448 "Release of noradrenaline at the synapse, Homo sapiens"
xref: Reactome:REACT_15483 "Acetylcholine synaptic vesicle docking and priming, Homo sapiens"
xref: Reactome:REACT_15503 "Release of docked serotonin loaded synaptic vesicle, Homo sapiens"
xref: Reactome:REACT_15517 "Dopamine synaptic vesicle docking and priming, Homo sapiens"
xref: Reactome:REACT_15533 "Release of docked dopamine loaded synaptic vesicle, Homo sapiens"
xref: Reactome:REACT_15541 "Traversal of the cortical actin network and docking at plasma membrane, Homo sapiens"
xref: Reactome:REACT_23813 "Release of GABA at the synapse, Homo sapiens"
xref: Reactome:REACT_23973 "GABA loaded synaptic vesicle Docking and Priming, Homo sapiens"
xref: Reactome:REACT_29535 "Acetylcholine synaptic vesicle docking and priming, Danio rerio"
xref: Reactome:REACT_31215 "Exocytosis of Insulin, Rattus norvegicus"
xref: Reactome:REACT_31588 "Vamp2 associated secretory vesicle to plasma membrane transport, Danio rerio"
xref: Reactome:REACT_34035 "Vamp2 associated secretory vesicle to plasma membrane transport, Mus musculus"
xref: Reactome:REACT_77361 "Vamp2 associated secretory vesicle to plasma membrane transport, Sus scrofa"
xref: Reactome:REACT_77506 "Glutamate synaptic vesicle docking and priming, Danio rerio"
xref: Reactome:REACT_77785 "Vamp7 associated Lysosome to Plasma membrane transport, Danio rerio"
xref: Reactome:REACT_77831 "release of L-Glutamate at the synapse, Mus musculus"
xref: Reactome:REACT_79299 "Glutamate synaptic vesicle docking and priming, Mus musculus"
xref: Reactome:REACT_80371 "Vamp2 associated secretory vesicle to plasma membrane transport, Bos taurus"
xref: Reactome:REACT_82023 "Acetylcholine synaptic vesicle docking and priming, Mus musculus"
xref: Reactome:REACT_82703 "Vamp7 associated Lysosome to Plasma membrane transport, Canis familiaris"
xref: Reactome:REACT_83226 "Glutamate synaptic vesicle docking and priming, Rattus norvegicus"
xref: Reactome:REACT_84308 "Release of noradrenaline at the synapse, Canis familiaris"
xref: Reactome:REACT_84628 "Exocytosis of Insulin, Xenopus tropicalis"
xref: Reactome:REACT_87193 "Glutamate synaptic vesicle docking and priming, Canis familiaris"
xref: Reactome:REACT_87411 "Vamp8 associated secretory vesicle to plasma membrane transport, Canis familiaris"
xref: Reactome:REACT_87768 "Vamp2 associated secretory vesicle to plasma membrane transport, Xenopus tropicalis"
xref: Reactome:REACT_90536 "Vamp7 associated Lysosome to Plasma membrane transport, Arabidopsis thaliana"
xref: Reactome:REACT_92466 "Vamp8 associated secretory vesicle to plasma membrane transport, Bos taurus"
xref: Reactome:REACT_93575 "Release of acetylcholine at the synapse, Rattus norvegicus"
xref: Reactome:REACT_93655 "Release of acetylcholine at the synapse, Canis familiaris"
xref: Reactome:REACT_93705 "Noradrenalin synaptic vesicle docking and priming, Rattus norvegicus"
xref: Reactome:REACT_94126 "Vamp8 associated secretory vesicle to plasma membrane transport, Danio rerio"
xref: Reactome:REACT_94434 "Exocytosis of Insulin, Bos taurus"
xref: Reactome:REACT_95323 "Vamp7 associated Lysosome to Plasma membrane transport, Oryza sativa"
xref: Reactome:REACT_96543 "Glutamate synaptic vesicle docking and priming, Xenopus tropicalis"
xref: Reactome:REACT_96609 "release of L-Glutamate at the synapse, Rattus norvegicus"
xref: Reactome:REACT_96753 "Acetylcholine synaptic vesicle docking and priming, Xenopus tropicalis"
xref: Reactome:REACT_96842 "Vamp8 associated secretory vesicle to plasma membrane transport, Mus musculus"
xref: Reactome:REACT_97101 "Exocytosis of Insulin, Canis familiaris"
xref: Reactome:REACT_98480 "Noradrenalin synaptic vesicle docking and priming, Xenopus tropicalis"
xref: Reactome:REACT_98819 "Noradrenalin synaptic vesicle docking and priming, Danio rerio"
xref: Reactome:REACT_99501 "Release of noradrenaline at the synapse, Mus musculus"
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0000150
name: recombinase activity
namespace: molecular_function
def: "Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA." [GOC:elh]
comment: Note that this term represents activities that do not break or form phosphodiester bonds, and is therefore not a parent of 'site-specific recombinase activity ; GO:0009009'.
subset: gosubset_prok
synonym: "strand transferase" NARROW []
xref: Reactome:REACT_27300 "Formation of Meiotic Heteroduplex, Homo sapiens"
is_a: GO:0003824 ! catalytic activity
relationship: part_of GO:0006310 ! DNA recombination

[Term]
id: GO:0000151
name: ubiquitin ligase complex
namespace: cellular_component
def: "A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603]
subset: goslim_pir
is_a: GO:0044424 ! intracellular part
is_a: GO:1990234 ! transferase complex

[Term]
id: GO:0000152
name: nuclear ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex found in the nucleus." [GOC:mah]
is_a: GO:0000151 ! ubiquitin ligase complex
is_a: GO:0044428 ! nuclear part
intersection_of: GO:0000151 ! ubiquitin ligase complex
intersection_of: part_of GO:0005634 ! nucleus
relationship: part_of GO:0005634 ! nucleus

[Term]
id: GO:0000153
name: cytoplasmic ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex found in the cytoplasm." [GOC:mah]
is_a: GO:0000151 ! ubiquitin ligase complex
is_a: GO:0044444 ! cytoplasmic part
intersection_of: GO:0000151 ! ubiquitin ligase complex
intersection_of: part_of GO:0005737 ! cytoplasm
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0000154
name: rRNA modification
namespace: biological_process
alt_id: GO:0016548
def: "The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]
comment: The term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing. Parallel changes were made for substrate (e.g. tRNA, rRNA, etc.) specific child terms of 'RNA editing'.
subset: gosubset_prok
synonym: "rRNA editing" NARROW [GOC:hjd]
is_a: GO:0006364 ! rRNA processing
is_a: GO:0009451 ! RNA modification

[Term]
id: GO:0000155
name: phosphorelay sensor kinase activity
namespace: molecular_function
def: "Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response." [GOC:bf, GOC:mcc, PMID:10966457, PMID:20223701, PMID:9191038]
subset: gosubset_prok
synonym: "two-component sensor activity" NARROW []
synonym: "two-component sensor molecule" NARROW []
synonym: "two-component system sensor activity" NARROW []
xref: EC:2.7.3.-
is_a: GO:0004673 ! protein histidine kinase activity
is_a: GO:0005057 ! receptor signaling protein activity
is_a: GO:0038023 ! signaling receptor activity
relationship: part_of GO:0000160 ! phosphorelay signal transduction system
relationship: part_of GO:0023014 ! signal transduction by protein phosphorylation

[Term]
id: GO:0000156
name: phosphorelay response regulator activity
namespace: molecular_function
def: "Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response." [GOC:bf, PMID:10966457, PMID:11842140]
subset: goslim_metagenomics
subset: gosubset_prok
synonym: "two-component response regulator activity" NARROW []
is_a: GO:0005057 ! receptor signaling protein activity
relationship: part_of GO:0000160 ! phosphorelay signal transduction system
relationship: part_of GO:0035556 ! intracellular signal transduction

[Term]
id: GO:0000159
name: protein phosphatase type 2A complex
namespace: cellular_component
def: "A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit." [GOC:mah, ISBN:0198547684, PMID:17245430]
synonym: "protein phosphatase 2 complex" RELATED [GOC:dph, GOC:rl]
is_a: GO:0008287 ! protein serine/threonine phosphatase complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0000160
name: phosphorelay signal transduction system
namespace: biological_process
def: "A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins." [PMID:9191038]
subset: goslim_metagenomics
subset: gosubset_prok
synonym: "histidyl-aspartyl phosphorelay" EXACT []
synonym: "phosphorelay signal transduction system" NARROW []
is_a: GO:0035556 ! intracellular signal transduction

[Term]
id: GO:0000161
name: MAPK cascade involved in osmosensory signaling pathway
namespace: biological_process
def: "A MAPK cascade involved in signal transduction in response to change in osmotic conditions." [PMID:9561267]
synonym: "High Osmolarity Glycerol (HOG) MAPK pathway" NARROW [PMID:20880736]
synonym: "Hog1 MAPK pathway" NARROW [PMID:20880736]
synonym: "MAPKKK cascade during osmolarity sensing" EXACT []
synonym: "MAPKKK cascade involved in osmosensory signaling pathway" EXACT [GOC:signaling]
synonym: "MAPKKK cascade involved in osmosensory signalling pathway" EXACT [GOC:mah]
synonym: "osmolarity sensing, MAPKKK cascade" EXACT []
is_a: GO:0000165 ! MAPK cascade
intersection_of: GO:0000165 ! MAPK cascade
intersection_of: part_of GO:0007231 ! osmosensory signaling pathway
relationship: part_of GO:0007231 ! osmosensory signaling pathway

[Term]
id: GO:0000162
name: tryptophan biosynthetic process
namespace: biological_process
alt_id: GO:0009096
def: "The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; tryptophan is synthesized from chorismate via anthranilate." [GOC:mah, ISBN:0471331309, MetaCyc:TRPSYN-PWY]
subset: gosubset_prok
synonym: "aromatic amino acid family biosynthetic process, anthranilate pathway" EXACT []
synonym: "tryptophan anabolism" EXACT []
synonym: "tryptophan biosynthesis" EXACT []
synonym: "tryptophan formation" EXACT []
synonym: "tryptophan synthesis" EXACT []
xref: MetaCyc:TRPSYN-PWY
is_a: GO:0006568 ! tryptophan metabolic process
is_a: GO:0009073 ! aromatic amino acid family biosynthetic process
is_a: GO:0046219 ! indolalkylamine biosynthetic process
is_a: GO:1901607 ! alpha-amino acid biosynthetic process

[Term]
id: GO:0000164
name: protein phosphatase type 1 complex
namespace: cellular_component
def: "A protein complex that possesses magnesium-dependent protein serine/threonine phosphatase (AMD phosphatase) activity, and consists of a catalytic subunit and one or more regulatory subunits that dictates the phosphatase's substrate specificity, function, and activity." [GOC:mah, GOC:ssd]
is_a: GO:0008287 ! protein serine/threonine phosphatase complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0000165
name: MAPK cascade
namespace: biological_process
def: "An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell." [GOC:bf, GOC:mtg_signaling_feb11, PMID:20811974, PMID:9561267]
comment: MAPK cascades lie downstream of many cell surface receptors and cooperate in transmitting various extracellular signals to the nucleus. One way by which the specificity of each cascade is regulated is through the existence of several distinct components in each tier of the different cascades. The cascades are typically named according to the component in the MAPK tier.
synonym: "ERK/MAPK cascade" NARROW []
synonym: "MAP kinase cascade" EXACT []
synonym: "MAP kinase kinase kinase cascade" EXACT []
synonym: "MAPK signal transduction" EXACT [GOC:signaling]
synonym: "MAPK signaling" RELATED []
synonym: "MAPK signalling" RELATED []
synonym: "MAPKKK cascade" EXACT [GOC:curators]
synonym: "MAPKKK cascade during sporulation" NARROW []
synonym: "mitogen-activated protein kinase cascade" EXACT [GOC:bf]
xref: Reactome:REACT_101634 "RAF/MAP kinase cascade, Bos taurus"
xref: Reactome:REACT_107261 "RAF/MAP kinase cascade, Saccharomyces cerevisiae"
xref: Reactome:REACT_107863 "RAF/MAP kinase cascade, Canis familiaris"
xref: Reactome:REACT_108330 "RAF/MAP kinase cascade, Xenopus tropicalis"
xref: Reactome:REACT_112235 "RAF/MAP kinase cascade, Dictyostelium discoideum"
xref: Reactome:REACT_112942 "RAF/MAP kinase cascade, Arabidopsis thaliana"
xref: Reactome:REACT_113285 "RAF/MAP kinase cascade, Oryza sativa"
xref: Reactome:REACT_634 "RAF/MAP kinase cascade, Homo sapiens"
xref: Reactome:REACT_79658 "RAF/MAP kinase cascade, Schizosaccharomyces pombe"
xref: Reactome:REACT_85806 "RAF/MAP kinase cascade, Drosophila melanogaster"
xref: Reactome:REACT_87028 "RAF/MAP kinase cascade, Danio rerio"
xref: Reactome:REACT_87232 "RAF/MAP kinase cascade, Mus musculus"
xref: Reactome:REACT_87855 "RAF/MAP kinase cascade, Rattus norvegicus"
xref: Reactome:REACT_92078 "RAF/MAP kinase cascade, Sus scrofa"
xref: Reactome:REACT_92987 "RAF/MAP kinase cascade, Caenorhabditis elegans"
xref: Reactome:REACT_94585 "RAF/MAP kinase cascade, Taeniopygia guttata"
xref: Reactome:REACT_94805 "RAF/MAP kinase cascade, Gallus gallus"
xref: Wikipedia:MAPK_cascade
xref: Wikipedia:Mitogen-activated_protein_kinase
is_a: GO:0023014 ! signal transduction by protein phosphorylation
is_a: GO:0035556 ! intracellular signal transduction

[Term]
id: GO:0000166
name: nucleotide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
subset: goslim_chembl
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
is_a: GO:0036094 ! small molecule binding
is_a: GO:1901265 ! nucleoside phosphate binding

[Term]
id: GO:0000167
name: activation of MAPKKK activity involved in osmosensory signaling pathway
namespace: biological_process
def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase during osmolarity sensing." [PMID:9561267]
synonym: "activation of MAP kinase kinase kinase activity during osmolarity sensing" EXACT []
synonym: "activation of MAPKKK activity during osmolarity sensing" EXACT []
synonym: "activation of MAPKKK activity involved in osmosensory signalling pathway" EXACT [GOC:mah]
synonym: "osmolarity sensing, activation of MAP kinase kinase kinase activity" EXACT []
synonym: "osmolarity sensing, activation of MAPKKK activity" EXACT []
is_a: GO:0000185 ! activation of MAPKKK activity
is_a: GO:0047484 ! regulation of response to osmotic stress
is_a: GO:0080135 ! regulation of cellular response to stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0038081 ! MAP kinase kinase kinase activity involved in osmosensory signaling pathway
relationship: positively_regulates GO:0038081 ! MAP kinase kinase kinase activity involved in osmosensory signaling pathway

[Term]
id: GO:0000168
name: activation of MAPKK activity involved in osmosensory signaling pathway
namespace: biological_process
alt_id: GO:0007233
def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase during osmolarity sensing." [PMID:9561267]
synonym: "activation of MAP kinase kinase activity during osmolarity sensing" EXACT []
synonym: "activation of MAPKK activity during osmolarity sensing" EXACT []
synonym: "activation of MAPKK activity involved in osmosensory signalling pathway" EXACT [GOC:mah]
synonym: "activation of Pbs2 kinase" NARROW []
synonym: "osmolarity sensing, activation of MAP kinase kinase activity" EXACT []
synonym: "osmolarity sensing, activation of MAPKK activity" EXACT []
is_a: GO:0000186 ! activation of MAPKK activity
is_a: GO:0047484 ! regulation of response to osmotic stress
is_a: GO:0080135 ! regulation of cellular response to stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0038080 ! MAP kinase kinase activity involved in osmosensory signaling pathway
relationship: positively_regulates GO:0038080 ! MAP kinase kinase activity involved in osmosensory signaling pathway

[Term]
id: GO:0000169
name: activation of MAPK activity involved in osmosensory signaling pathway
namespace: biological_process
def: "Any process that initiates the activity of the inactive enzyme MAP kinase activity during osmolarity sensing." [PMID:9561267]
synonym: "activation of MAPK activity during osmolarity sensing" EXACT []
synonym: "activation of MAPK activity involved in osmosensory signalling pathway" EXACT [GOC:mah]
synonym: "osmolarity sensing, activation of MAPK activity" EXACT []
is_a: GO:0000187 ! activation of MAPK activity
is_a: GO:0047484 ! regulation of response to osmotic stress
is_a: GO:0080135 ! regulation of cellular response to stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0038079 ! MAP kinase activity involved in osmosensory signaling pathway
relationship: positively_regulates GO:0038079 ! MAP kinase activity involved in osmosensory signaling pathway

[Term]
id: GO:0000170
name: sphingosine hydroxylase activity
namespace: molecular_function
def: "Catalysis of the hydroxylation of sphingolipid long chain bases." [PMID:9556590]
xref: Reactome:REACT_100351 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O, Danio rerio"
xref: Reactome:REACT_103503 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O, Gallus gallus"
xref: Reactome:REACT_104963 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O, Canis familiaris"
xref: Reactome:REACT_115687 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O, Gallus gallus"
xref: Reactome:REACT_19258 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O, Homo sapiens"
xref: Reactome:REACT_29940 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O, Oryza sativa"
xref: Reactome:REACT_31871 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O, Drosophila melanogaster"
xref: Reactome:REACT_80095 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O, Bos taurus"
xref: Reactome:REACT_82371 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O, Xenopus tropicalis"
xref: Reactome:REACT_85471 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O, Dictyostelium discoideum"
xref: Reactome:REACT_85651 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O, Sus scrofa"
xref: Reactome:REACT_86222 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O, Arabidopsis thaliana"
xref: Reactome:REACT_91283 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O, Schizosaccharomyces pombe"
xref: Reactome:REACT_92284 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O, Rattus norvegicus"
xref: Reactome:REACT_96037 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O, Taeniopygia guttata"
xref: Reactome:REACT_97092 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O, Caenorhabditis elegans"
xref: Reactome:REACT_99475 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O, Mus musculus"
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0000171
name: ribonuclease MRP activity
namespace: molecular_function
def: "Catalysis of the site-specific cleavage of RNA by a catalytic RNA-mediated mechanism; substrates include the A3 site in the ITS1 of pre-rRNA." [PMID:17881380]
synonym: "RNase MRP" EXACT []
xref: Wikipedia:RNase_MRP
is_a: GO:0004540 ! ribonuclease activity

[Term]
id: GO:0000172
name: ribonuclease MRP complex
namespace: cellular_component
def: "A ribonucleoprotein complex that contains an RNA molecule of the snoRNA family, and cleaves the rRNA precursor as part of rRNA transcript processing. It also has other roles: In S. cerevisiae it is involved in cell cycle-regulated degradation of daughter cell-specific mRNAs, while in mammalian cells it also enters the mitochondria and processes RNAs to create RNA primers for DNA replication." [GOC:sgd_curators, PMID:10690410, PMID:14729943, PMID:7510714]
synonym: "ribonuclease mitochondrial RNA processing complex" EXACT []
synonym: "RNase MRP complex" EXACT []
is_a: GO:0005732 ! small nucleolar ribonucleoprotein complex

[Term]
id: GO:0000173
name: inactivation of MAPK activity involved in osmosensory signaling pathway
namespace: biological_process
def: "Any process that terminates the activity of the active enzyme MAP kinase during osmolarity sensing." [PMID:9561267]
synonym: "inactivation of MAPK activity during osmolarity sensing" EXACT []
synonym: "inactivation of MAPK activity involved in osmosensory signalling pathway" EXACT [GOC:mah]
synonym: "osmolarity sensing, inactivation of MAPK" EXACT []
synonym: "osmolarity sensing, termination of MAPK activity" EXACT []
synonym: "termination of MAPK activity during osmolarity sensing" EXACT []
is_a: GO:0000188 ! inactivation of MAPK activity
is_a: GO:0047484 ! regulation of response to osmotic stress
is_a: GO:0080135 ! regulation of cellular response to stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007231 ! osmosensory signaling pathway
relationship: negatively_regulates GO:0007231 ! osmosensory signaling pathway
relationship: negatively_regulates GO:0038079 ! MAP kinase activity involved in osmosensory signaling pathway

[Term]
id: GO:0000174
name: obsolete inactivation of MAPK (mating sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. Downregulation of MAP kinase activity in the context of transduction of mating pheromone signal, as described for Saccharomyces." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "inactivation of MAPK (mating sensu Saccharomyces)" EXACT []
is_obsolete: true
replaced_by: GO:0000750

[Term]
id: GO:0000175
name: 3'-5'-exoribonuclease activity
namespace: molecular_function
def: "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684]
subset: gosubset_prok
synonym: "3'-5' exoribonuclease activity" EXACT []
xref: EC:3.1.13.-
xref: Reactome:REACT_102966 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Schizosaccharomyces pombe"
xref: Reactome:REACT_108214 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Sus scrofa"
xref: Reactome:REACT_20588 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Homo sapiens"
xref: Reactome:REACT_33991 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Dictyostelium discoideum"
xref: Reactome:REACT_34078 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Danio rerio"
xref: Reactome:REACT_78363 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Bos taurus"
xref: Reactome:REACT_82118 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Rattus norvegicus"
xref: Reactome:REACT_88115 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Arabidopsis thaliana"
xref: Reactome:REACT_89880 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Oryza sativa"
xref: Reactome:REACT_92153 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Caenorhabditis elegans"
xref: Reactome:REACT_93499 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Drosophila melanogaster"
xref: Reactome:REACT_95913 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Canis familiaris"
xref: Reactome:REACT_95921 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Mus musculus"
xref: Reactome:REACT_96267 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Taeniopygia guttata"
xref: Reactome:REACT_99422 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Xenopus tropicalis"
is_a: GO:0008408 ! 3'-5' exonuclease activity
is_a: GO:0016896 ! exoribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0000176
name: nuclear exosome (RNase complex)
namespace: cellular_component
def: "Complex of 3'-5' exoribonucleases found in the nucleus." [PMID:10465791]
synonym: "eukaryotic exosome multienzyme ribonuclease complex" EXACT []
synonym: "nuclear exosome (ribonuclease complex)" EXACT []
synonym: "nuclear exosome multienzyme ribonuclease complex" EXACT []
is_a: GO:0000178 ! exosome (RNase complex)
is_a: GO:0044428 ! nuclear part
intersection_of: GO:0000178 ! exosome (RNase complex)
intersection_of: part_of GO:0005634 ! nucleus
relationship: part_of GO:0005634 ! nucleus
relationship: part_of GO:0031981 ! nuclear lumen

[Term]
id: GO:0000177
name: cytoplasmic exosome (RNase complex)
namespace: cellular_component
def: "Complex of 3'-5' exoribonucleases found in the cytoplasm." [PMID:10465791]
synonym: "cytoplasmic exosome (ribonuclease complex)" EXACT []
synonym: "cytoplasmic exosome multienzyme ribonuclease complex" EXACT []
synonym: "prokaryotic exosome multienzyme ribonuclease complex" EXACT []
is_a: GO:0000178 ! exosome (RNase complex)
is_a: GO:0044444 ! cytoplasmic part
intersection_of: GO:0000178 ! exosome (RNase complex)
intersection_of: part_of GO:0005737 ! cytoplasm
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0000178
name: exosome (RNase complex)
namespace: cellular_component
def: "Complex of 3'-5' exoribonucleases." [PMID:10465791]
comment: Note that this term should not be confused with 'exosome' used in the context of vesicles released from multivesicular bodies.
subset: goslim_pir
synonym: "exosome (ribonucleasease complex)" EXACT []
synonym: "exosome multienzyme ribonuclease complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0000179
name: rRNA (adenine-N6,N6-)-dimethyltransferase activity
namespace: molecular_function
alt_id: GO:0043790
def: "Catalysis of the dimethylation two adjacent A residues in the loop closing the 3'-terminal stem of the 18S rRNA, using S-adenosyl-L-methionine as a methyl donor." [ISBN:1555811337, PMID:10690410]
subset: gosubset_prok
synonym: "18S rRNA dimethylase activity" EXACT []
synonym: "dimethyladenosine transferase activity" EXACT [IMG:02532]
synonym: "S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase activity" EXACT [IMG:02532]
xref: EC:2.1.1.-
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0016433 ! rRNA (adenine) methyltransferase activity

[Term]
id: GO:0000180
name: obsolete cytosolic large ribosomal subunit
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because more specific children exist.
synonym: "cytosolic large ribosomal subunit" EXACT []
is_obsolete: true
consider: GO:0022625

[Term]
id: GO:0000181
name: obsolete cytosolic small ribosomal subunit
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because more specific children exist.
synonym: "cytosolic small ribosomal subunit" EXACT []
is_obsolete: true
consider: GO:0022627

[Term]
id: GO:0000182
name: rDNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with DNA sequences encoding ribosomal RNA." [GOC:mah]
synonym: "ribosomal DNA binding" EXACT []
is_a: GO:1990837 ! sequence-specific double-stranded DNA binding

[Term]
id: GO:0000183
name: chromatin silencing at rDNA
namespace: biological_process
def: "Repression of transcription of ribosomal DNA by altering the structure of chromatin." [PMID:10219245]
synonym: "chromatin silencing at ribosomal DNA" EXACT []
synonym: "heterochromatic silencing at rDNA" EXACT []
synonym: "rDNA chromatin silencing" EXACT [GOC:mah]
is_a: GO:0006342 ! chromatin silencing

[Term]
id: GO:0000184
name: nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
namespace: biological_process
def: "The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins." [GOC:krc, GOC:ma, PMID:10025395]
synonym: "mRNA breakdown, nonsense-mediated decay" EXACT []
synonym: "mRNA catabolic process, nonsense-mediated" EXACT []
synonym: "mRNA catabolism, nonsense-mediated" EXACT []
synonym: "mRNA degradation, nonsense-mediated decay" EXACT []
synonym: "nonsense-mediated mRNA decay" EXACT []
synonym: "nuclear mRNA catabolic process, nonsense-mediated decay" EXACT []
xref: Reactome:REACT_75886 "Nonsense-Mediated Decay, Homo sapiens"
xref: Wikipedia:Nonsense-mediated_decay
xref: Wikipedia:Nonsense-mediated_mRNA_decay
is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process

[Term]
id: GO:0000185
name: activation of MAPKKK activity
namespace: biological_process
def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase (MAPKKK)." [PMID:9561267]
synonym: "activation of MAP kinase kinase kinase" EXACT []
synonym: "activation of MAP3K activity" EXACT [GOC:bf]
synonym: "activation of MAPKKK activity during sporulation" NARROW []
synonym: "positive regulation of MAP kinase kinase kinase activity" BROAD []
synonym: "positive regulation of MAPKKK activity" BROAD []
is_a: GO:0032147 ! activation of protein kinase activity
is_a: GO:0043405 ! regulation of MAP kinase activity
is_a: GO:0043410 ! positive regulation of MAPK cascade
is_a: GO:0071902 ! positive regulation of protein serine/threonine kinase activity
relationship: positively_regulates GO:0004709 ! MAP kinase kinase kinase activity

[Term]
id: GO:0000186
name: activation of MAPKK activity
namespace: biological_process
alt_id: GO:0007255
def: "The initiation of the activity of the inactive enzyme MAP kinase kinase (MAPKK)." [PMID:9561267]
synonym: "activation of MAP kinase kinase activity" EXACT []
synonym: "activation of MAP/ERK kinase kinase" EXACT []
synonym: "activation of MAP2K activity" EXACT [GOC:bf]
synonym: "activation of MAPKK activity during sporulation" NARROW []
synonym: "positive regulation of MAPKK activity" BROAD []
xref: Reactome:REACT_101798 "Prolonged ERK activation events, Mus musculus"
xref: Reactome:REACT_102728 "Prolonged ERK activation events, Schizosaccharomyces pombe"
xref: Reactome:REACT_103900 "Prolonged ERK activation events, Gallus gallus"
xref: Reactome:REACT_104177 "MEK activation, Danio rerio"
xref: Reactome:REACT_104271 "Prolonged ERK activation events, Canis familiaris"
xref: Reactome:REACT_110634 "MEK activation, Canis familiaris"
xref: Reactome:REACT_113771 "Prolonged ERK activation events, Arabidopsis thaliana"
xref: Reactome:REACT_114228 "Prolonged ERK activation events, Dictyostelium discoideum"
xref: Reactome:REACT_114817 "Prolonged ERK activation events, Oryza sativa"
xref: Reactome:REACT_12005 "Prolonged ERK activation events, Homo sapiens"
xref: Reactome:REACT_33773 "Prolonged ERK activation events, Caenorhabditis elegans"
xref: Reactome:REACT_81505 "MEK activation, Gallus gallus"
xref: Reactome:REACT_81553 "Prolonged ERK activation events, Xenopus tropicalis"
xref: Reactome:REACT_82861 "MEK activation, Xenopus tropicalis"
xref: Reactome:REACT_86719 "Prolonged ERK activation events, Rattus norvegicus"
xref: Reactome:REACT_86891 "Prolonged ERK activation events, Bos taurus"
xref: Reactome:REACT_87045 "Prolonged ERK activation events, Taeniopygia guttata"
xref: Reactome:REACT_89175 "Prolonged ERK activation events, Danio rerio"
xref: Reactome:REACT_89555 "MEK activation, Bos taurus"
xref: Reactome:REACT_91625 "Prolonged ERK activation events, Drosophila melanogaster"
xref: Reactome:REACT_94138 "Prolonged ERK activation events, Sus scrofa"
xref: Reactome:REACT_94626 "MEK activation, Mus musculus"
xref: Reactome:REACT_95763 "MEK activation, Taeniopygia guttata"
xref: Reactome:REACT_962 "MEK activation, Homo sapiens"
xref: Reactome:REACT_97271 "Prolonged ERK activation events, Saccharomyces cerevisiae"
xref: Reactome:REACT_98727 "MEK activation, Rattus norvegicus"
is_a: GO:0032147 ! activation of protein kinase activity
is_a: GO:0043405 ! regulation of MAP kinase activity
is_a: GO:0043410 ! positive regulation of MAPK cascade
relationship: positively_regulates GO:0004708 ! MAP kinase kinase activity

[Term]
id: GO:0000187
name: activation of MAPK activity
namespace: biological_process
def: "The initiation of the activity of the inactive enzyme MAP kinase (MAPK)." [PMID:9561267]
synonym: "activation of MAP kinase" EXACT []
synonym: "activation of MAPK activity during sporulation" NARROW []
synonym: "MAPK activation" EXACT []
xref: Reactome:REACT_100881 "activated TAK1 mediates p38 MAPK activation, Canis familiaris"
xref: Reactome:REACT_101870 "ERK activation, Caenorhabditis elegans"
xref: Reactome:REACT_101978 "ERK activation, Drosophila melanogaster"
xref: Reactome:REACT_102664 "activated TAK1 mediates p38 MAPK activation, Caenorhabditis elegans"
xref: Reactome:REACT_102813 "activated TAK1 mediates p38 MAPK activation, Arabidopsis thaliana"
xref: Reactome:REACT_103235 "ERK activation, Sus scrofa"
xref: Reactome:REACT_103251 "activated TAK1 mediates p38 MAPK activation, Dictyostelium discoideum"
xref: Reactome:REACT_106101 "ERK activation, Bos taurus"
xref: Reactome:REACT_112664 "ERK activation, Oryza sativa"
xref: Reactome:REACT_113767 "ERK activation, Dictyostelium discoideum"
xref: Reactome:REACT_114778 "ERK activation, Arabidopsis thaliana"
xref: Reactome:REACT_1482 "ERK activation, Homo sapiens"
xref: Reactome:REACT_21399 "activated TAK1 mediates p38 MAPK activation, Homo sapiens"
xref: Reactome:REACT_25355 "MAPK activation in TLR cascade, Gallus gallus"
xref: Reactome:REACT_25370 "Activated TAK1 mediates p38 MAP kinase phosphorylation, Gallus gallus"
xref: Reactome:REACT_28684 "ERK activation, Gallus gallus"
xref: Reactome:REACT_29727 "activated TAK1 mediates p38 MAPK activation, Xenopus tropicalis"
xref: Reactome:REACT_30502 "ERK activation, Saccharomyces cerevisiae"
xref: Reactome:REACT_32301 "activated TAK1 mediates p38 MAPK activation, Rattus norvegicus"
xref: Reactome:REACT_34590 "ERK activation, Rattus norvegicus"
xref: Reactome:REACT_77440 "activated TAK1 mediates p38 MAPK activation, Mus musculus"
xref: Reactome:REACT_77987 "ERK activation, Taeniopygia guttata"
xref: Reactome:REACT_78017 "activated TAK1 mediates p38 MAPK activation, Bos taurus"
xref: Reactome:REACT_83894 "activated TAK1 mediates p38 MAPK activation, Sus scrofa"
xref: Reactome:REACT_84937 "ERK activation, Schizosaccharomyces pombe"
xref: Reactome:REACT_86273 "activated TAK1 mediates p38 MAPK activation, Taeniopygia guttata"
xref: Reactome:REACT_86655 "activated TAK1 mediates p38 MAPK activation, Danio rerio"
xref: Reactome:REACT_87442 "activated TAK1 mediates p38 MAPK activation, Drosophila melanogaster"
xref: Reactome:REACT_88492 "ERK activation, Canis familiaris"
xref: Reactome:REACT_88606 "ERK activation, Mus musculus"
xref: Reactome:REACT_91962 "activated TAK1 mediates p38 MAPK activation, Oryza sativa"
xref: Reactome:REACT_93371 "activated TAK1 mediates p38 MAPK activation, Gallus gallus"
xref: Reactome:REACT_98123 "ERK activation, Xenopus tropicalis"
xref: Reactome:REACT_99633 "ERK activation, Danio rerio"
is_a: GO:0032147 ! activation of protein kinase activity
is_a: GO:0043406 ! positive regulation of MAP kinase activity

[Term]
id: GO:0000188
name: inactivation of MAPK activity
namespace: biological_process
def: "Any process that terminates the activity of the active enzyme MAP kinase." [PMID:9561267]
synonym: "inactivation of MAPK during sporulation" NARROW []
synonym: "termination of MAPK activity" EXACT []
is_a: GO:0043407 ! negative regulation of MAP kinase activity

[Term]
id: GO:0000189
name: MAPK import into nucleus
namespace: biological_process
def: "The directed movement of a MAP kinase to the nucleus upon activation." [PMID:9561267]
comment: Note that 'translocation' is sometimes used in the literature to refer to the entire process of protein import into the nucleus, but in GO refers specifically to the step in which a cargo-carrier protein complex moves through the nuclear pore complex.
synonym: "nuclear translocation of MAPK" NARROW [GOC:mah]
xref: Reactome:REACT_103042 "Nuclear translocation of phospho-ERK-1 dimer, Schizosaccharomyces pombe"
xref: Reactome:REACT_105886 "Nuclear translocation of phospho-ERK-2 dimer, Gallus gallus"
xref: Reactome:REACT_106064 "Nuclear translocation of phospho-ERK-2 dimer, Mus musculus"
xref: Reactome:REACT_107045 "Nuclear translocation of phospho-ERK-1 dimer, Canis familiaris"
xref: Reactome:REACT_110766 "Nuclear translocation of phospho-ERK-1 dimer, Danio rerio"
xref: Reactome:REACT_113196 "Nuclear translocation of phospho-ERK-1 dimer, Oryza sativa"
xref: Reactome:REACT_114932 "Nuclear translocation of phospho-ERK-1 dimer, Dictyostelium discoideum"
xref: Reactome:REACT_115101 "Nuclear translocation of phospho-ERK-1 dimer, Arabidopsis thaliana"
xref: Reactome:REACT_1866 "Nuclear translocation of phospho-ERK-1 dimer, Homo sapiens"
xref: Reactome:REACT_29004 "Nuclear translocation of phospho-ERK-1 dimer, Caenorhabditis elegans"
xref: Reactome:REACT_32259 "Nuclear translocation of phospho-ERK-1 dimer, Saccharomyces cerevisiae"
xref: Reactome:REACT_33595 "Nuclear translocation of phospho-ERK-1 dimer, Mus musculus"
xref: Reactome:REACT_487 "Nuclear translocation of phospho-ERK-2 dimer, Homo sapiens"
xref: Reactome:REACT_510 "Nuclear translocation of phospho-ERK-2 dimer, Rattus norvegicus"
xref: Reactome:REACT_78269 "Nuclear translocation of phospho-ERK-2 dimer, Danio rerio"
xref: Reactome:REACT_79422 "Nuclear translocation of phospho-ERK-2 dimer, Bos taurus"
xref: Reactome:REACT_81446 "Nuclear translocation of phospho-ERK-2 dimer, Taeniopygia guttata"
xref: Reactome:REACT_87335 "Nuclear translocation of phospho-ERK-2 dimer, Xenopus tropicalis"
xref: Reactome:REACT_89933 "Nuclear translocation of phospho-ERK-1 dimer, Drosophila melanogaster"
xref: Reactome:REACT_94910 "Nuclear translocation of phospho-ERK-1 dimer, Bos taurus"
xref: Reactome:REACT_95119 "Nuclear translocation of phospho-ERK-2 dimer, Sus scrofa"
xref: Reactome:REACT_97762 "Nuclear translocation of phospho-ERK-2 dimer, Canis familiaris"
is_a: GO:0006606 ! protein import into nucleus
relationship: part_of GO:0000165 ! MAPK cascade

[Term]
id: GO:0000190
name: obsolete MAPKKK cascade (pseudohyphal growth)
namespace: biological_process
def: "OBSOLETE. MAPKKK cascade involved in transduction of signal promoting pseudohyphal or invasive growth." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "MAPKKK cascade (pseudohyphal growth)" EXACT []
is_obsolete: true

[Term]
id: GO:0000191
name: obsolete activation of MAPKKK (pseudohyphal growth)
namespace: biological_process
def: "OBSOLETE. Upregulation of MAPKKK activity in the context of regulating pseudohyphal or invasive growth." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "activation of MAPKKK (pseudohyphal growth)" EXACT []
is_obsolete: true

[Term]
id: GO:0000192
name: obsolete activation of MAPKK (pseudohyphal growth)
namespace: biological_process
def: "OBSOLETE. Upregulation of a MAP kinase kinase in the context of regulating pseudohyphal or invasive growth." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "activation of MAPKK (pseudohyphal growth)" EXACT []
is_obsolete: true

[Term]
id: GO:0000193
name: obsolete activation of MAPK (pseudohyphal growth)
namespace: biological_process
def: "OBSOLETE. Upregulation of MAP kinase activity in the context of regulating pseudohyphal or invasive growth." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "activation of MAPK (pseudohyphal growth)" EXACT []
is_obsolete: true

[Term]
id: GO:0000194
name: obsolete inactivation of MAPK (pseudohyphal growth)
namespace: biological_process
def: "OBSOLETE. Downregulation of MAP kinase activity in the context of regulating pseudohyphal or invasive growth." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "inactivation of MAPK (pseudohyphal growth)" EXACT []
is_obsolete: true

[Term]
id: GO:0000195
name: obsolete nuclear translocation of MAPK (pseudohyphal growth)
namespace: biological_process
def: "OBSOLETE. Movement of a MAP kinase to the nucleus in the context of regulating pseudohyphal or invasive growth." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "nuclear translocation of MAPK (pseudohyphal growth)" EXACT []
is_obsolete: true

[Term]
id: GO:0000196
name: MAPK cascade involved in cell wall organization or biogenesis
namespace: biological_process
def: "A MAPK cascade that contributes to cell wall organization or biogenesis." [PMID:9561267]
synonym: "cell integrity MAPK pathway" EXACT [GOC:vw, PMID:23934882]
synonym: "cell wall biogenesis, MAPKKK cascade" EXACT []
synonym: "MAPK cascade involved in cell wall biogenesis" NARROW [GOC:vw]
synonym: "MAPKKK cascade involved in cell wall biogenesis" EXACT [GOC:signaling]
synonym: "Mpk1 cascade" NARROW [PMID:10523653]
synonym: "Pmk1 MAPK cell integrity signaling" NARROW [PMID:20032302]
synonym: "Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway" NARROW [PMID:23934882]
synonym: "PMK1-MAPK signal transduction pathway" NARROW [PMID:23454094]
synonym: "Slt2 cascade" NARROW [PMID:10523653]
is_a: GO:0000165 ! MAPK cascade
intersection_of: GO:0000165 ! MAPK cascade
intersection_of: part_of GO:0071554 ! cell wall organization or biogenesis
relationship: part_of GO:0071554 ! cell wall organization or biogenesis

[Term]
id: GO:0000197
name: activation of MAPKKK activity involved in cell wall organization or biogenesis
namespace: biological_process
def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase in the context of cell wall organization or biogenesis." [PMID:9561267]
synonym: "activation of MAP kinase kinase kinase activity during cell wall biogenesis" EXACT []
synonym: "activation of MAPKKK activity involved in cell wall biogenesis" RELATED []
synonym: "activation of MAPKKK activity involved in cell wall integrity" EXACT [GOC:dgf]
synonym: "cell wall biogenesis, activation of MAP kinase kinase kinase activity" EXACT []
synonym: "cell wall biogenesis, activation of MAPKKK activity" EXACT []
is_a: GO:0000185 ! activation of MAPKKK activity
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:1903139 ! positive regulation of MAPK cascade involved in cell wall organization or biogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0038070 ! MAP kinase kinase kinase activity involved in cell wall organization or biogenesis
relationship: positively_regulates GO:0038070 ! MAP kinase kinase kinase activity involved in cell wall organization or biogenesis

[Term]
id: GO:0000198
name: activation of MAPKK activity involved in cell wall organization or biogenesis
namespace: biological_process
def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase in the context of cell wall organization or biogenesis." [PMID:9561267]
synonym: "activation of MAP kinase kinase activity during cell wall biogenesis" EXACT []
synonym: "activation of MAPKK activity involved in cell wall biogenesis" RELATED []
synonym: "activation of MAPKK activity involved in cell wall integrity" EXACT [GOC:dgf]
synonym: "cell wall biogenesis, activation of MAP kinase kinase activity" EXACT []
synonym: "cell wall biogenesis, activation of MAPKK activity" EXACT []
is_a: GO:0000186 ! activation of MAPKK activity
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:1903139 ! positive regulation of MAPK cascade involved in cell wall organization or biogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0038068 ! MAP kinase kinase activity involved in cell wall organization or biogenesis
relationship: positively_regulates GO:0038068 ! MAP kinase kinase activity involved in cell wall organization or biogenesis

[Term]
id: GO:0000199
name: activation of MAPK activity involved in cell wall organization or biogenesis
namespace: biological_process
def: "Any process that initiates the activity of the inactive enzyme MAP kinase in the context of cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells." [PMID:9561267]
synonym: "activation of MAPK activity involved in cell wall biogenesis" NARROW []
synonym: "activation of MAPK activity involved in cell wall integrity" EXACT [GOC:dgf]
synonym: "cell wall biogenesis, activation of MAPK activity" EXACT []
is_a: GO:0000187 ! activation of MAPK activity
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:1903139 ! positive regulation of MAPK cascade involved in cell wall organization or biogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0038067 ! MAP kinase activity involved in cell wall organization or biogenesis
relationship: positively_regulates GO:0038067 ! MAP kinase activity involved in cell wall organization or biogenesis

[Term]
id: GO:0000200
name: inactivation of MAPK activity involved in cell wall organization or biogenesis
namespace: biological_process
def: "Any process that terminates the activity of the active enzyme MAP kinase in the context of cell wall organization or biogenesis." [PMID:9561267]
synonym: "cell wall biogenesis, inactivation of MAPK activity" EXACT []
synonym: "cell wall biogenesis, termination of MAPK activity" EXACT []
synonym: "inactivation of MAPK activity involved in cell wall integrity" EXACT [GOC:dgf]
synonym: "inactivation of MAPK activity involved in cell wall organization or biogenesis" RELATED []
synonym: "termination of MAPK activity during cell wall biogenesis" EXACT []
is_a: GO:0000188 ! inactivation of MAPK activity
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:1903138 ! negative regulation of MAPK cascade involved in cell wall organization or biogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0038067 ! MAP kinase activity involved in cell wall organization or biogenesis
relationship: negatively_regulates GO:0038067 ! MAP kinase activity involved in cell wall organization or biogenesis

[Term]
id: GO:0000201
name: MAPK import into nucleus involved in cell wall organization or biogenesis
namespace: biological_process
def: "The directed movement of a MAP kinase to the nucleus that occurs in the context of cell wall organization or biogenesis." [PMID:9561267]
synonym: "cell wall biogenesis, MAPK import into nucleus" EXACT [GOC:mah]
synonym: "cell wall biogenesis, nuclear translocation of MAPK" NARROW [GOC:mah]
synonym: "MAPK import into nucleus involved in cell wall biogenesis" NARROW [GOC:vw]
synonym: "MAPK import into nucleus involved in cell wall integrity" EXACT [GOC:dgf, GOC:mah]
synonym: "nuclear translocation of MAPK involved in cell wall biogenesis" NARROW [GOC:mah]
synonym: "nuclear translocation of MAPK involved in cell wall integrity" NARROW [GOC:dgf, GOC:mah]
is_a: GO:0000189 ! MAPK import into nucleus
intersection_of: GO:0000189 ! MAPK import into nucleus
intersection_of: part_of GO:0042546 ! cell wall biogenesis
relationship: part_of GO:0000196 ! MAPK cascade involved in cell wall organization or biogenesis
relationship: part_of GO:0042546 ! cell wall biogenesis

[Term]
id: GO:0000202
name: obsolete MAPKKK cascade during sporulation (sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. MAPKKK cascade involved in transduction of signal promoting sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "MAPKKK cascade during sporulation (sensu Saccharomyces)" EXACT []
is_obsolete: true

[Term]
id: GO:0000203
name: obsolete activation of MAPKKK during sporulation (sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. Upregulation of MAPKKK activity in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "activation of MAPKKK during sporulation (sensu Saccharomyces)" EXACT []
is_obsolete: true

[Term]
id: GO:0000204
name: obsolete activation of MAPKK during sporulation (sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. Upregulation of a MAP kinase kinase in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "activation of MAPKK during sporulation (sensu Saccharomyces)" EXACT []
is_obsolete: true

[Term]
id: GO:0000205
name: obsolete activation of MAPK during sporulation (sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. Upregulation of MAP kinase activity in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "activation of MAPK during sporulation (sensu Saccharomyces)" EXACT []
is_obsolete: true

[Term]
id: GO:0000206
name: obsolete inactivation of MAPK during sporulation (sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. Downregulation of MAP kinase activity in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "inactivation of MAPK during sporulation (sensu Saccharomyces)" EXACT []
is_obsolete: true

[Term]
id: GO:0000207
name: obsolete nuclear translocation of MAPK during sporulation (sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. Movement of a MAP kinase to the nucleus in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "nuclear translocation of MAPK during sporulation (sensu Saccharomyces)" EXACT []
is_obsolete: true

[Term]
id: GO:0000208
name: MAPK import into nucleus involved in osmosensory signaling pathway
namespace: biological_process
def: "The directed movement of a MAP kinase to the nucleus during osmolarity sensing." [PMID:9561267]
synonym: "MAPK import into nucleus during osmolarity sensing" EXACT [GOC:mah]
synonym: "MAPK import into nucleus involved in osmosensory signalling pathway" EXACT [GOC:mah]
synonym: "nuclear translocation of MAPK during osmolarity sensing" EXACT []
synonym: "nuclear translocation of MAPK involved in osmosensory signaling pathway" NARROW [GOC:mah]
synonym: "nuclear translocation of MAPK involved in osmosensory signalling pathway" NARROW [GOC:mah]
synonym: "osmolarity sensing, MAPK import into nucleus" EXACT [GOC:mah]
synonym: "osmolarity sensing, nuclear translocation of MAPK" NARROW [GOC:mah]
is_a: GO:0000189 ! MAPK import into nucleus
intersection_of: GO:0000189 ! MAPK import into nucleus
intersection_of: part_of GO:0007231 ! osmosensory signaling pathway
relationship: part_of GO:0000161 ! MAPK cascade involved in osmosensory signaling pathway
relationship: part_of GO:0007231 ! osmosensory signaling pathway

[Term]
id: GO:0000209
name: protein polyubiquitination
namespace: biological_process
def: "Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [ISBN:0815316194]
synonym: "polyubiquitin" RELATED []
synonym: "protein polyubiquitinylation" EXACT []
synonym: "protein polyubiquitylation" EXACT []
xref: Reactome:REACT_75842 "Antigen processing: Ubiquitination & Proteasome degradation, Homo sapiens"
is_a: GO:0016567 ! protein ubiquitination

[Term]
id: GO:0000210
name: NAD+ diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + H2O = AMP + NMN." [EC:3.6.1.22]
subset: gosubset_prok
synonym: "NAD diphosphatase activity" EXACT []
synonym: "NAD pyrophosphatase activity" EXACT []
synonym: "NAD(+) pyrophosphatase activity" EXACT [EC:3.6.1.22]
synonym: "NAD+ phosphohydrolase activity" EXACT [EC:3.6.1.22]
synonym: "NAD+ pyrophosphatase activity" EXACT [EC:3.6.1.22]
synonym: "NADH pyrophosphatase activity" BROAD [EC:3.6.1.22]
synonym: "NADP pyrophosphatase activity" BROAD [EC:3.6.1.22]
synonym: "nicotinamide adenine dinucleotide pyrophosphatase activity" EXACT [EC:3.6.1.22]
xref: EC:3.6.1.22
xref: MetaCyc:NADPYROPHOSPHAT-RXN
xref: RHEA:11803
is_a: GO:0004551 ! nucleotide diphosphatase activity

[Term]
id: GO:0000211
name: obsolete protein degradation tagging activity
namespace: molecular_function
def: "OBSOLETE. Covalent addition of polyubiquitin to another protein, targeting the tagged protein for destruction." [GOC:cl, ISBN:0815316194]
comment: This term was made obsolete because it represents a biological process and a molecular function.
synonym: "protein degradation tagging activity" EXACT []
is_obsolete: true
consider: GO:0005515
consider: GO:0019941
consider: GO:0042787

[Term]
id: GO:0000212
name: meiotic spindle organization
namespace: biological_process
alt_id: GO:0043147
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a meiotic cell cycle." [GOC:go_curators, GOC:mah]
synonym: "meiotic spindle organisation" EXACT [GOC:curators]
synonym: "meiotic spindle organization and biogenesis" RELATED [GOC:mah]
synonym: "meiotic spindle stabilization" RELATED []
synonym: "spindle organization during meiosis" EXACT [GOC:mah]
is_a: GO:0007051 ! spindle organization
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0000213
name: tRNA-intron endonuclease activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron." [EC:3.1.27.9]
synonym: "splicing endonuclease activity" EXACT [EC:3.1.27.9]
synonym: "transfer ribonucleate intron endoribonuclease activity" EXACT [EC:3.1.27.9]
synonym: "transfer splicing endonuclease activity" EXACT [EC:3.1.27.9]
synonym: "tRNA splicing endonuclease activity" EXACT [EC:3.1.27.9]
synonym: "tRNA-intron endoribonuclease activity" EXACT []
synonym: "tRNA-splicing endonuclease activity" EXACT [EC:3.1.27.9]
synonym: "tRNATRPintron endonuclease activity" EXACT [EC:3.1.27.9]
xref: EC:3.1.27.9
xref: MetaCyc:3.1.27.9-RXN
is_a: GO:0004549 ! tRNA-specific ribonuclease activity
is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters

[Term]
id: GO:0000214
name: tRNA-intron endonuclease complex
namespace: cellular_component
def: "A protein complex that catalyzes the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron." [EC:3.1.27.9]
synonym: "SEN complex" EXACT [GOC:se, PMID:22391451]
synonym: "tRNA splicing endonuclease complex" EXACT [GOC:se, PMID:22391451]
is_a: GO:0044428 ! nuclear part
is_a: GO:1902555 ! endoribonuclease complex

[Term]
id: GO:0000215
name: tRNA 2'-phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2'-phospho-[ligated tRNA] + NAD+ = mature tRNA + ADP ribose 1'',2''-phosphate + nicotinamide + H2O. This reaction is the transfer of the splice junction 2-phosphate from ligated tRNA to NAD+ to produce ADP-ribose 1'-2' cyclic phosphate." [EC:2.7.1.160, PMID:9148937]
subset: goslim_chembl
synonym: "2'-phospho-[ligated tRNA]:NAD+ phosphotransferase activity" EXACT [EC:2.7.1.160]
synonym: "2'-phospho-tRNA:NAD+ phosphotransferase activity" EXACT [EC:2.7.1.160]
synonym: "Tpt1" RELATED [EC:2.7.1.160]
synonym: "Tpt1p" RELATED [EC:2.7.1.160]
synonym: "yeast 2'-phosphotransferase activity" NARROW [EC:2.7.1.160]
xref: EC:2.7.1.160
xref: MetaCyc:2.7.1.160-RXN
is_a: GO:0008665 ! 2'-phosphotransferase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0000216
name: obsolete M/G1 transition of mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Progression from M phase to G1 phase of the mitotic cell cycle." [GOC:mah, GOC:mtg_cell_cycle]
comment: This term was made obsolete because it does not refer to a real biological process.
synonym: "M/G1 transition of mitotic cell cycle" EXACT []
xref: Reactome:REACT_103126 "M/G1 Transition, Sus scrofa"
xref: Reactome:REACT_103368 "M/G1 Transition, Taeniopygia guttata"
xref: Reactome:REACT_105126 "M/G1 Transition, Caenorhabditis elegans"
xref: Reactome:REACT_108209 "M/G1 Transition, Schizosaccharomyces pombe"
xref: Reactome:REACT_108301 "M/G1 Transition, Saccharomyces cerevisiae"
xref: Reactome:REACT_109437 "M/G1 Transition, Rattus norvegicus"
xref: Reactome:REACT_110954 "M/G1 Transition, Dictyostelium discoideum"
xref: Reactome:REACT_1725 "M/G1 Transition, Homo sapiens"
xref: Reactome:REACT_32146 "M/G1 Transition, Arabidopsis thaliana"
xref: Reactome:REACT_32196 "M/G1 Transition, Plasmodium falciparum"
xref: Reactome:REACT_77227 "M/G1 Transition, Danio rerio"
xref: Reactome:REACT_77394 "M/G1 Transition, Mus musculus"
xref: Reactome:REACT_78459 "M/G1 Transition, Gallus gallus"
xref: Reactome:REACT_79481 "M/G1 Transition, Drosophila melanogaster"
xref: Reactome:REACT_83776 "M/G1 Transition, Oryza sativa"
xref: Reactome:REACT_86397 "M/G1 Transition, Canis familiaris"
xref: Reactome:REACT_89032 "M/G1 Transition, Xenopus tropicalis"
xref: Reactome:REACT_94915 "M/G1 Transition, Bos taurus"
is_obsolete: true

[Term]
id: GO:0000217
name: DNA secondary structure binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with DNA containing secondary structure elements such as four-way junctions, bubbles, loops, Y-form DNA, or double-strand/single-strand junctions." [GOC:krc]
is_a: GO:0043566 ! structure-specific DNA binding

[Term]
id: GO:0000219
name: obsolete vacuolar hydrogen-transporting ATPase
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because more specific terms were created.
synonym: "V-ATPase" EXACT []
synonym: "vacuolar hydrogen-transporting ATPase" EXACT []
is_obsolete: true
consider: GO:0016469

[Term]
id: GO:0000220
name: vacuolar proton-transporting V-type ATPase, V0 domain
namespace: cellular_component
def: "The V0 domain of a proton-transporting V-type ATPase found in the vacuolar membrane." [GOC:mah, PMID:16449553]
comment: Note that this domain often consists of five subunits, although in some mammalian tissues it may have an additional subunit.
synonym: "vacuolar hydrogen ion-transporting ATPase V0 domain" EXACT []
is_a: GO:0033179 ! proton-transporting V-type ATPase, V0 domain
is_a: GO:0044437 ! vacuolar part
intersection_of: GO:0033179 ! proton-transporting V-type ATPase, V0 domain
intersection_of: part_of GO:0005773 ! vacuole
relationship: part_of GO:0005773 ! vacuole
relationship: part_of GO:0016471 ! vacuolar proton-transporting V-type ATPase complex

[Term]
id: GO:0000221
name: vacuolar proton-transporting V-type ATPase, V1 domain
namespace: cellular_component
def: "The V1 domain of a proton-transporting V-type ATPase found in the vacuolar membrane." [GOC:mah, PMID:16449553]
comment: Note that this domain generally consists of eight subunits.
synonym: "vacuolar hydrogen ion-transporting ATPase V1 domain" EXACT []
is_a: GO:0033180 ! proton-transporting V-type ATPase, V1 domain
is_a: GO:0044437 ! vacuolar part
intersection_of: GO:0033180 ! proton-transporting V-type ATPase, V1 domain
intersection_of: part_of GO:0005773 ! vacuole
relationship: part_of GO:0005773 ! vacuole
relationship: part_of GO:0016471 ! vacuolar proton-transporting V-type ATPase complex

[Term]
id: GO:0000222
name: plasma membrane proton-transporting V-type ATPase, V0 domain
namespace: cellular_component
def: "The V0 domain of a proton-transporting V-type ATPase found in the plasma membrane." [GOC:mah]
synonym: "plasma membrane hydrogen ion-transporting ATPase V0 domain" EXACT []
is_a: GO:0033179 ! proton-transporting V-type ATPase, V0 domain
is_a: GO:0098797 ! plasma membrane protein complex
intersection_of: GO:0033179 ! proton-transporting V-type ATPase, V0 domain
intersection_of: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0005887 ! integral component of plasma membrane
relationship: part_of GO:0033181 ! plasma membrane proton-transporting V-type ATPase complex

[Term]
id: GO:0000223
name: plasma membrane proton-transporting V-type ATPase, V1 domain
namespace: cellular_component
def: "The V1 domain of a proton-transporting V-type ATPase found in the plasma membrane." [GOC:mah]
synonym: "plasma membrane hydrogen ion-transporting ATPase V1 domain" EXACT []
is_a: GO:0033180 ! proton-transporting V-type ATPase, V1 domain
is_a: GO:0098797 ! plasma membrane protein complex
intersection_of: GO:0033180 ! proton-transporting V-type ATPase, V1 domain
intersection_of: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0005887 ! integral component of plasma membrane
relationship: part_of GO:0033181 ! plasma membrane proton-transporting V-type ATPase complex

[Term]
id: GO:0000224
name: peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-N-(N-acetyl-D-glucosaminyl)-protein + H2O = N-acetyl-beta-D-glucosaminylamine + peptide L-aspartate. This reaction is the hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the N-acetyl-D-glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue." [EC:3.5.1.52]
subset: gosubset_prok
synonym: "glycopeptidase activity" BROAD [EC:3.5.1.52]
synonym: "glycopeptide N-glycosidase activity" BROAD [EC:3.5.1.52]
synonym: "jack-bean glycopeptidase" NARROW [EC:3.5.1.52]
synonym: "N-glycanase activity" RELATED [EC:3.5.1.52]
synonym: "N-linked-glycopeptide-(N-acetyl-beta-D-glucosaminyl)-L-asparagine amidohydrolase activity" EXACT [EC:3.5.1.52]
synonym: "N-oligosaccharide glycopeptidase activity" RELATED [EC:3.5.1.52]
synonym: "peptide:N-glycanase" RELATED []
synonym: "PNGase" EXACT []
synonym: "PNGase A" RELATED [EC:3.5.1.52]
synonym: "PNGase F" RELATED [EC:3.5.1.52]
xref: EC:3.5.1.52
xref: MetaCyc:3.5.1.52-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0000225
name: N-acetylglucosaminylphosphatidylinositol deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-D-glucosaminylphosphatidylinositol + H2O = D-glucosaminylphosphatidylinositol + acetate. This reaction is the second step of the biosynthesis of glycosylphosphatidylinositol (GPI), used to anchor various eukaryotic proteins to the cell-surface membrane." [EC:3.5.1.89]
comment: Note that this function was formerly EC:3.1.1.69.
synonym: "6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol acetylhydrolase activity" EXACT [EC:3.5.1.89]
synonym: "acetylglucosaminylphosphatidylinositol deacetylase activity" EXACT [EC:3.5.1.89]
synonym: "GlcNAc-PI de-N-acetylase activity" EXACT [EC:3.5.1.89]
synonym: "GlcNAc-PI deacetylase activity" EXACT [EC:3.5.1.89]
synonym: "N-acetyl-D-glucosaminylphosphatidylinositol acetylhydrolase activity" EXACT [EC:3.5.1.89]
synonym: "N-acetylglucosaminylphosphatidylinositol de-N-acetylase activity" EXACT [EC:3.5.1.89]
xref: EC:3.5.1.89
xref: MetaCyc:3.1.1.69-RXN
xref: Reactome:REACT_100003 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate, Gallus gallus"
xref: Reactome:REACT_103061 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate, Taeniopygia guttata"
xref: Reactome:REACT_107021 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate, Caenorhabditis elegans"
xref: Reactome:REACT_111009 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate, Dictyostelium discoideum"
xref: Reactome:REACT_114989 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate, Arabidopsis thaliana"
xref: Reactome:REACT_29732 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate, Schizosaccharomyces pombe"
xref: Reactome:REACT_32276 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate, Saccharomyces cerevisiae"
xref: Reactome:REACT_33502 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate, Bos taurus"
xref: Reactome:REACT_33809 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate, Drosophila melanogaster"
xref: Reactome:REACT_77843 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate, Danio rerio"
xref: Reactome:REACT_779 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate, Homo sapiens"
xref: Reactome:REACT_82306 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate, Oryza sativa"
xref: Reactome:REACT_82765 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate, Mus musculus"
xref: Reactome:REACT_88022 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate, Plasmodium falciparum"
xref: Reactome:REACT_88604 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate, Canis familiaris"
xref: Reactome:REACT_91074 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate, Rattus norvegicus"
xref: Reactome:REACT_98776 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate, Sus scrofa"
xref: RHEA:11663
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0019213 ! deacetylase activity

[Term]
id: GO:0000226
name: microtubule cytoskeleton organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
synonym: "microtubule cytoskeleton organisation" EXACT [GOC:mah]
synonym: "microtubule cytoskeleton organization and biogenesis" RELATED [GOC:mah]
synonym: "microtubule dynamics" EXACT [GOC:dph, GOC:tb]
is_a: GO:0007010 ! cytoskeleton organization
is_a: GO:0007017 ! microtubule-based process
is_a: GO:1902589 ! single-organism organelle organization

[Term]
id: GO:0000227
name: oxaloacetate secondary active transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of oxaloacetate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport]
synonym: "oxaloacetate carrier activity" RELATED []
is_a: GO:0015131 ! oxaloacetate transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0000228
name: nuclear chromosome
namespace: cellular_component
def: "A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah]
subset: goslim_chembl
subset: goslim_generic
synonym: "nuclear interphase chromosome" NARROW []
is_a: GO:0005694 ! chromosome
is_a: GO:0044428 ! nuclear part
intersection_of: GO:0005694 ! chromosome
intersection_of: part_of GO:0005634 ! nucleus
relationship: part_of GO:0005634 ! nucleus
relationship: part_of GO:0031981 ! nuclear lumen

[Term]
id: GO:0000229
name: cytoplasmic chromosome
namespace: cellular_component
def: "A chromosome found in the cytoplasm." [GOC:mah]
subset: goslim_chembl
subset: goslim_generic
subset: gosubset_prok
synonym: "cytoplasmic interphase chromosome" NARROW []
is_a: GO:0005694 ! chromosome
is_a: GO:0044444 ! cytoplasmic part
intersection_of: GO:0005694 ! chromosome
intersection_of: part_of GO:0005737 ! cytoplasm
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0000230
name: obsolete nuclear mitotic chromosome
namespace: cellular_component
def: "OBSOLETE. A chromosome found in the nucleus during mitosis." [GOC:mah]
comment: This term was made obsolete because it is based on a temporal division of the cell cycle.
synonym: "nuclear mitotic chromosome" EXACT []
is_obsolete: true
consider: GO:0000794

[Term]
id: GO:0000231
name: obsolete cytoplasmic mitotic chromosome
namespace: cellular_component
def: "OBSOLETE. A chromosome found in the cytoplasm during mitosis." [GOC:mah]
comment: This term was made obsolete because it is based on a temporal division of the cell cycle.
synonym: "cytoplasmic mitotic chromosome" EXACT []
is_obsolete: true
consider: GO:0000793

[Term]
id: GO:0000232
name: obsolete nuclear interphase chromosome
namespace: cellular_component
def: "OBSOLETE. A chromosome found in the nucleus during interphase." [GOC:mah]
comment: This term was made obsolete because it is based on a temporal division of the cell cycle.
synonym: "nuclear interphase chromosome" EXACT []
is_obsolete: true
consider: GO:0000228

[Term]
id: GO:0000233
name: obsolete cytoplasmic interphase chromosome
namespace: cellular_component
def: "OBSOLETE. A chromosome found in the cytoplasm during interphase." [GOC:mah]
comment: This term was made obsolete because it is based on a temporal division of the cell cycle.
synonym: "cytoplasmic interphase chromosome" EXACT []
is_obsolete: true
consider: GO:0000229

[Term]
id: GO:0000234
name: phosphoethanolamine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + ethanolamine phosphate = S-adenosyl-L-homocysteine + N-methylethanolamine phosphate." [EC:2.1.1.103]
synonym: "phosphoethanolamine methyltransferase activity" EXACT [EC:2.1.1.103]
synonym: "S-adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase activity" EXACT [EC:2.1.1.103]
xref: EC:2.1.1.103
xref: KEGG:R02037
xref: MetaCyc:2.1.1.103-RXN
xref: RHEA:20368
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0000235
name: astral microtubule
namespace: cellular_component
def: "Any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell." [ISBN:0815316194]
is_a: GO:0005876 ! spindle microtubule
is_a: GO:0005881 ! cytoplasmic microtubule
intersection_of: GO:0005876 ! spindle microtubule
intersection_of: part_of GO:0005818 ! aster
relationship: part_of GO:0005818 ! aster

[Term]
id: GO:0000236
name: mitotic prometaphase
namespace: biological_process
def: "The cell cycle phase in higher eukaryotes which follows mitotic prophase and during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region. Kinetochores mature on each centromere and attach to some of the spindle microtubules. Kinetochore microtubules begin the process of aligning chromosomes in one plane halfway between the poles." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
xref: Reactome:REACT_102823 "Mitotic Prometaphase, Mus musculus"
xref: Reactome:REACT_104270 "Mitotic Prometaphase, Bos taurus"
xref: Reactome:REACT_105082 "Mitotic Prometaphase, Dictyostelium discoideum"
xref: Reactome:REACT_114704 "Mitotic Prometaphase, Schizosaccharomyces pombe"
xref: Reactome:REACT_118069 "Mitotic Prometaphase, Gallus gallus"
xref: Reactome:REACT_118526 "Mitotic Prometaphase, Saccharomyces cerevisiae"
xref: Reactome:REACT_118539 "Mitotic Prometaphase, Taeniopygia guttata"
xref: Reactome:REACT_31336 "Mitotic Prometaphase, Danio rerio"
xref: Reactome:REACT_31385 "Mitotic Prometaphase, Caenorhabditis elegans"
xref: Reactome:REACT_682 "Mitotic Prometaphase, Homo sapiens"
xref: Reactome:REACT_79351 "Mitotic Prometaphase, Rattus norvegicus"
xref: Reactome:REACT_83126 "Mitotic Prometaphase, Drosophila melanogaster"
xref: Reactome:REACT_98905 "Mitotic Prometaphase, Xenopus tropicalis"
xref: Reactome:REACT_99376 "Mitotic Prometaphase, Canis familiaris"
is_a: GO:0098763 ! mitotic cell cycle phase
relationship: happens_during GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0000237
name: leptotene
namespace: biological_process
def: "The cell cycle phase which is the first stage of prophase I in meiosis, and during which the chromosomes first become visible." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
xref: Wikipedia:Leptotene
xref: Wikipedia:Meiosis#Leptotene
is_a: GO:0098764 ! meiosis I cell cycle phase
relationship: part_of GO:0007128 ! meiotic prophase I

[Term]
id: GO:0000238
name: zygotene
namespace: biological_process
def: "The cell cycle phase which follows leptotene during prophase I of meiosis, and during which each chromosome pairs with its homolog; the two become aligned and crossing over may occur." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
xref: Wikipedia:Meiosis#Zygotene
xref: Wikipedia:Zygotene
is_a: GO:0098764 ! meiosis I cell cycle phase
relationship: part_of GO:0007128 ! meiotic prophase I

[Term]
id: GO:0000239
name: pachytene
namespace: biological_process
def: "The cell cycle phase which follows zygotene during prophase I of meiosis, and during which crossing over occurs between a chromatid in one partner and another chromatid in the homologous chromosome." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
xref: Wikipedia:Meiosis#Pachytene
xref: Wikipedia:Pachytene
is_a: GO:0098764 ! meiosis I cell cycle phase
relationship: part_of GO:0007128 ! meiotic prophase I

[Term]
id: GO:0000240
name: diplotene
namespace: biological_process
def: "The cell cycle phase which follows pachytene during prophase I of meiosis, during which the homologous chromosomes begin to separate and the synaptonemal complex dissolves." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
xref: Wikipedia:Diplotene
xref: Wikipedia:Meiosis#Diplotene
is_a: GO:0098764 ! meiosis I cell cycle phase
relationship: part_of GO:0007128 ! meiotic prophase I

[Term]
id: GO:0000241
name: diakinesis
namespace: biological_process
def: "The cell cycle phase which follows diplotene during prophase I of meiosis, the separation of homologous chromosomes is complete and crossing over has occurred." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
xref: Wikipedia:Diakinesis
xref: Wikipedia:Meiosis#Diakinesis
is_a: GO:0098764 ! meiosis I cell cycle phase
relationship: part_of GO:0007128 ! meiotic prophase I

[Term]
id: GO:0000242
name: pericentriolar material
namespace: cellular_component
def: "A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome." [GOC:clt, ISBN:0815316194]
is_a: GO:0044450 ! microtubule organizing center part
relationship: part_of GO:0005813 ! centrosome

[Term]
id: GO:0000243
name: commitment complex
namespace: cellular_component
def: "A spliceosomal complex that is formed by association of the U1 snRNP with the 5' splice site of an unspliced intron in an RNA transcript." [GOC:krc, ISBN:0879695897, PMID:9150140]
synonym: "mammalian spliceosomal complex E" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "mammalian spliceosomal E complex" NARROW [GOC:mah]
synonym: "yeast spliceosomal complex CC" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
is_a: GO:0005684 ! U2-type spliceosomal complex
relationship: has_part GO:0005685 ! U1 snRNP

[Term]
id: GO:0000244
name: spliceosomal tri-snRNP complex assembly
namespace: biological_process
alt_id: GO:0000351
alt_id: GO:0000355
def: "The formation of a tri-snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. This includes reannealing of U4 and U6 (or U4atac and U6atac) snRNAs released from previous rounds of splicing to reform the U4/U6 snRNP (or U4atac/U6atac snRNP) as well as the subsequent association of the U5 snRNP with the U4/U6 snRNP (or U4atac/U6atac snRNP) to form a tri-snRNP that is ready to reassemble into another spliceosome complex." [ISBN:0879695897, PMID:9452384]
synonym: "assembly of spliceosomal tri-snRNP" EXACT []
synonym: "assembly of spliceosomal tri-snRNP U4/U6.U5" NARROW []
synonym: "assembly of spliceosomal tri-snRNP U4atac/U6atac.U5" NARROW []
synonym: "snRNP recycling" BROAD []
synonym: "spliceosomal tri-snRNP assembly" EXACT []
synonym: "spliceosomal tri-snRNP U4/U6.U5 assembly" NARROW []
synonym: "spliceosomal tri-snRNP U4atac/U6atac.U5 assembly" NARROW []
is_a: GO:0000387 ! spliceosomal snRNP assembly

[Term]
id: GO:0000245
name: spliceosomal complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions." [PMID:9476892]
synonym: "spliceosome assembly" BROAD []
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0000398 ! mRNA splicing, via spliceosome

[Term]
id: GO:0000246
name: delta24(24-1) sterol reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: ergosterol + NADP(+) = ergosta-5,7,22,24(24(1))-tetraen-3beta-ol + H(+) + NADPH." [EC:1.3.1.71, RHEA:18504]
subset: gosubset_prok
synonym: "C-24(28) sterol reductase activity" EXACT [EC:1.3.1.71]
synonym: "D24(24-1)-sterol reductase activity" EXACT []
synonym: "delta24(241)-sterol reductase activity" EXACT [EC:1.3.1.71]
synonym: "ergosterol:NADP+ delta24(241)-oxidoreductase activity" EXACT [EC:1.3.1.71]
synonym: "sterol Delta(24(28))-methylene reductase activity" EXACT [EC:1.3.1.71]
synonym: "sterol Delta(24(28))-reductase activity" EXACT [EC:1.3.1.71]
synonym: "sterol delta-24(28) methylene reductase activity" EXACT []
synonym: "sterol delta-24(28) reductase activity" EXACT []
synonym: "sterol delta24(28)-methylene reductase activity" EXACT [EC:1.3.1.71]
synonym: "sterol delta24(28)-reductase activity" EXACT [EC:1.3.1.71]
xref: EC:1.3.1.71
xref: KEGG:R05641
xref: MetaCyc:1.3.1.71-RXN
xref: RHEA:18504
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0000247
name: C-8 sterol isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction which results in unsaturation at C-7 in the B ring of sterols." [MetaCyc:RXN3O-203, PMID:8988026]
synonym: "delta-8-delta-7 sterol isomerase activity" EXACT []
xref: EC:5.3.3.-
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0000248
name: C-5 sterol desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+." [MetaCyc:RXN3O-227]
synonym: "sterol-C5-desaturase activity" EXACT []
xref: Reactome:REACT_10092 "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol, Homo sapiens"
xref: Reactome:REACT_106801 "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol, Taeniopygia guttata"
xref: Reactome:REACT_108498 "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol, Rattus norvegicus"
xref: Reactome:REACT_110659 "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol, Bos taurus"
xref: Reactome:REACT_34122 "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol, Danio rerio"
xref: Reactome:REACT_34697 "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol, Saccharomyces cerevisiae"
xref: Reactome:REACT_79598 "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol, Mus musculus"
xref: Reactome:REACT_84206 "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol, Oryza sativa"
xref: Reactome:REACT_85577 "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol, Sus scrofa"
xref: Reactome:REACT_86700 "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol, Canis familiaris"
xref: Reactome:REACT_98513 "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol, Schizosaccharomyces pombe"
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
is_a: GO:0070704 ! sterol desaturase activity

[Term]
id: GO:0000249
name: C-22 sterol desaturase activity
namespace: molecular_function
def: "Catalysis of the formation of the C-22(23) double bond in the sterol side chain. An example reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+." [MetaCyc:RXN3O-227]
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
is_a: GO:0070704 ! sterol desaturase activity

[Term]
id: GO:0000250
name: lanosterol synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-2,3-epoxysqualene = lanosterol. This is a cyclization reaction that forms the sterol nucleus." [EC:5.4.99.7, RHEA:14624]
subset: gosubset_prok
synonym: "(S)-2,3-epoxysqualene mutase (cyclizing, lanosterol-forming)" EXACT [EC:5.4.99.7]
synonym: "2,3-epoxysqualene lanosterol cyclase activity" EXACT [EC:5.4.99.7]
synonym: "2,3-epoxysqualene--lanosterol cyclase activity" EXACT [EC:5.4.99.7]
synonym: "2,3-epoxysqualene-lanosterol cyclase activity" EXACT []
synonym: "2,3-oxidosqualene sterol cyclase activity" BROAD [EC:5.4.99.7]
synonym: "2,3-oxidosqualene-lanosterol cyclase activity" EXACT [EC:5.4.99.7]
synonym: "lanosterol 2,3-oxidosqualene cyclase activity" EXACT [EC:5.4.99.7]
synonym: "OSC" EXACT []
synonym: "oxidosqualene--lanosterol cyclase activity" EXACT [EC:5.4.99.7]
synonym: "oxidosqualene-lanosterol cyclase activity" EXACT []
synonym: "oxidosqualene:lanosterol cyclase activity" EXACT [PMID:18033581]
synonym: "squalene 2,3-epoxide:lanosterol cyclase activity" EXACT [EC:5.4.99.7]
synonym: "squalene epoxidase-cyclase activity" BROAD [EC:5.4.99.7]
synonym: "squalene-2,3-oxide-lanosterol cyclase activity" EXACT [EC:5.4.99.7]
xref: EC:5.4.99.7
xref: KEGG:R03199
xref: MetaCyc:LANOSTEROL-SYNTHASE-RXN
xref: Reactome:REACT_106250 "Squalene 2,3-epoxide cyclizes, forming lanosterol, Danio rerio"
xref: Reactome:REACT_112890 "Squalene 2,3-epoxide cyclizes, forming lanosterol, Oryza sativa"
xref: Reactome:REACT_114747 "Squalene 2,3-epoxide cyclizes, forming lanosterol, Arabidopsis thaliana"
xref: Reactome:REACT_29522 "Squalene 2,3-epoxide cyclizes, forming lanosterol, Schizosaccharomyces pombe"
xref: Reactome:REACT_33379 "Squalene 2,3-epoxide cyclizes, forming lanosterol, Xenopus tropicalis"
xref: Reactome:REACT_78122 "Squalene 2,3-epoxide cyclizes, forming lanosterol, Taeniopygia guttata"
xref: Reactome:REACT_84749 "Squalene 2,3-epoxide cyclizes, forming lanosterol, Bos taurus"
xref: Reactome:REACT_86645 "Squalene 2,3-epoxide cyclizes, forming lanosterol, Saccharomyces cerevisiae"
xref: Reactome:REACT_88346 "Squalene 2,3-epoxide cyclizes, forming lanosterol, Rattus norvegicus"
xref: Reactome:REACT_89548 "Squalene 2,3-epoxide cyclizes, forming lanosterol, Gallus gallus"
xref: Reactome:REACT_92166 "Squalene 2,3-epoxide cyclizes, forming lanosterol, Dictyostelium discoideum"
xref: Reactome:REACT_93681 "Squalene 2,3-epoxide cyclizes, forming lanosterol, Canis familiaris"
xref: Reactome:REACT_9391 "Squalene 2,3-epoxide cyclizes, forming lanosterol, Homo sapiens"
xref: Reactome:REACT_96289 "Squalene 2,3-epoxide cyclizes, forming lanosterol, Mus musculus"
xref: RHEA:14624
is_a: GO:0031559 ! oxidosqualene cyclase activity

[Term]
id: GO:0000252
name: C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-beta-hydroxy-4-beta-methyl-5-alpha-cholesta-8,24-dien-4-alpha-carboxylate + NAD(P)+ = 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-one + CO2 + NAD(P)H." [EC:1.1.1.170, PMID:9811880]
comment: Note that zymosterol is cholesta-8,24-dien-3-ol.
synonym: "3beta-hydroxy-4alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)" RELATED [EC:1.1.1.170]
synonym: "3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate:NAD(P)+ 3-oxidoreductase (decarboxylating)" EXACT []
synonym: "3beta-hydroxy-4beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)" RELATED []
synonym: "3beta-hydroxy-4beta-methylcholestenoate dehydrogenase activity" RELATED []
synonym: "C-3 sterol dehydrogenase (C-4 decarboxylase) activity" RELATED []
synonym: "C-3 sterol dehydrogenase activity" RELATED []
synonym: "sterol 4alpha-carboxylic decarboxylase activity" RELATED []
synonym: "sterol-4-carboxylate 3-dehydrogenase (decarboxylating) activity" RELATED []
synonym: "sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating)" RELATED []
xref: EC:1.1.1.-
xref: Reactome:REACT_10053 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one, Homo sapiens"
xref: Reactome:REACT_103278 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one, Sus scrofa"
xref: Reactome:REACT_103729 "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone), Bos taurus"
xref: Reactome:REACT_105643 "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone), Gallus gallus"
xref: Reactome:REACT_106602 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one, Bos taurus"
xref: Reactome:REACT_107465 "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone), Canis familiaris"
xref: Reactome:REACT_108692 "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone), Mus musculus"
xref: Reactome:REACT_108789 "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone), Rattus norvegicus"
xref: Reactome:REACT_109155 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one, Danio rerio"
xref: Reactome:REACT_112688 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one, Mycobacterium tuberculosis"
xref: Reactome:REACT_112771 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one, Escherichia coli"
xref: Reactome:REACT_112854 "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone), Schizosaccharomyces pombe"
xref: Reactome:REACT_112960 "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone), Saccharomyces cerevisiae"
xref: Reactome:REACT_112995 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one, Schizosaccharomyces pombe"
xref: Reactome:REACT_113072 "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone), Oryza sativa"
xref: Reactome:REACT_113373 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one, Dictyostelium discoideum"
xref: Reactome:REACT_113553 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one, Saccharomyces cerevisiae"
xref: Reactome:REACT_114106 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one, Oryza sativa"
xref: Reactome:REACT_114356 "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone), Dictyostelium discoideum"
xref: Reactome:REACT_115015 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one, Arabidopsis thaliana"
xref: Reactome:REACT_115441 "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone), Arabidopsis thaliana"
xref: Reactome:REACT_30127 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one, Rattus norvegicus"
xref: Reactome:REACT_31080 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one, Taeniopygia guttata"
xref: Reactome:REACT_32363 "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone), Sus scrofa"
xref: Reactome:REACT_33091 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one, Canis familiaris"
xref: Reactome:REACT_77107 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one, Gallus gallus"
xref: Reactome:REACT_82876 "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone), Xenopus tropicalis"
xref: Reactome:REACT_85383 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one, Mus musculus"
xref: Reactome:REACT_89091 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one, Xenopus tropicalis"
xref: Reactome:REACT_91545 "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone), Danio rerio"
xref: Reactome:REACT_91980 "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone), Taeniopygia guttata"
xref: Reactome:REACT_9949 "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone), Homo sapiens"
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0000253
name: 3-keto sterol reductase activity
namespace: molecular_function
alt_id: GO:0050576
def: "Catalysis of the reaction: a 3-beta-hydroxyl sterol + NADP+ = a 3-keto sterol + NADPH + H(+)." [EC:1.1.1.270, GOC:mah, MetaCyc:1.1.1.270-RXN, MetaCyc:RXN3O-4110, MetaCyc:RXN66-19, MetaCyc:RXN66-24, MetaCyc:RXN66-314, MetaCyc:RXN66-319, PMID:9811880]
comment: Note that zymosterol is cholesta-8,24-dien-3-ol.
synonym: "3-keto-steroid reductase activity" EXACT []
synonym: "3-KSR activity" EXACT [EC:1.1.1.270]
synonym: "3beta-hydroxy-steroid:NADP+ 3-oxidoreductase" RELATED [EC:1.1.1.270]
xref: EC:1.1.1.270
xref: MetaCyc:1.1.1.270-RXN
xref: MetaCyc:RXN3O-4110
xref: MetaCyc:RXN66-19
xref: MetaCyc:RXN66-24
xref: MetaCyc:RXN66-314
xref: MetaCyc:RXN66-319
xref: Reactome:REACT_10036 "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol, Homo sapiens"
xref: Reactome:REACT_10079 "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol), Homo sapiens"
xref: Reactome:REACT_101014 "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol), Schizosaccharomyces pombe"
xref: Reactome:REACT_102533 "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol, Xenopus tropicalis"
xref: Reactome:REACT_103243 "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol, Canis familiaris"
xref: Reactome:REACT_103645 "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol, Gallus gallus"
xref: Reactome:REACT_106908 "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol), Saccharomyces cerevisiae"
xref: Reactome:REACT_107179 "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol, Taeniopygia guttata"
xref: Reactome:REACT_108259 "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol), Canis familiaris"
xref: Reactome:REACT_31386 "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol, Danio rerio"
xref: Reactome:REACT_69122 "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol, Sus scrofa"
xref: Reactome:REACT_78849 "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol, Mus musculus"
xref: Reactome:REACT_79755 "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol, Rattus norvegicus"
xref: Reactome:REACT_82599 "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol, Schizosaccharomyces pombe"
xref: Reactome:REACT_82943 "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol), Sus scrofa"
xref: Reactome:REACT_84146 "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol), Gallus gallus"
xref: Reactome:REACT_88684 "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol), Bos taurus"
xref: Reactome:REACT_91551 "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol), Mus musculus"
xref: Reactome:REACT_92714 "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol), Rattus norvegicus"
xref: Reactome:REACT_95205 "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol), Taeniopygia guttata"
xref: Reactome:REACT_96469 "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol, Bos taurus"
xref: Reactome:REACT_96959 "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol), Danio rerio"
xref: Reactome:REACT_96973 "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol), Xenopus tropicalis"
xref: Reactome:REACT_97126 "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol, Saccharomyces cerevisiae"
xref: RHEA:18412
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0000254
name: C-4 methylsterol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)H + H(+) + O2 = 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)+ + H2O." [EC:1.14.13.72, PMID:9811880]
comment: Note that zymosterol is cholesta-8,24-dien-3-ol.
synonym: "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,hydrogen-donor:oxygen oxidoreductase (hydroxylating)" EXACT [EC:1.14.13.72]
synonym: "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,NAD(P)H:oxygen oxidoreductase (hydroxylating)" EXACT [EC:1.14.13.72]
synonym: "4-methylsterol oxidase activity" EXACT []
synonym: "methylsterol hydroxylase activity" RELATED []
synonym: "methylsterol monooxygenase activity" RELATED []
xref: EC:1.14.13.72
xref: MetaCyc:1.14.13.72-RXN
xref: Reactome:REACT_10059 "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol, Homo sapiens"
xref: Reactome:REACT_10070 "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol, Homo sapiens"
xref: Reactome:REACT_104089 "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol, Danio rerio"
xref: Reactome:REACT_104631 "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol, Oryza sativa"
xref: Reactome:REACT_105610 "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol, Taeniopygia guttata"
xref: Reactome:REACT_105653 "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol, Bos taurus"
xref: Reactome:REACT_107576 "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol, Dictyostelium discoideum"
xref: Reactome:REACT_112865 "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol, Xenopus tropicalis"
xref: Reactome:REACT_115505 "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol, Xenopus tropicalis"
xref: Reactome:REACT_28712 "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol, Mus musculus"
xref: Reactome:REACT_29355 "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol, Sus scrofa"
xref: Reactome:REACT_31445 "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol, Mus musculus"
xref: Reactome:REACT_32207 "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol, Sus scrofa"
xref: Reactome:REACT_32840 "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol, Saccharomyces cerevisiae"
xref: Reactome:REACT_76969 "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol, Oryza sativa"
xref: Reactome:REACT_79112 "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol, Schizosaccharomyces pombe"
xref: Reactome:REACT_83222 "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol, Gallus gallus"
xref: Reactome:REACT_84661 "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol, Schizosaccharomyces pombe"
xref: Reactome:REACT_84707 "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol, Arabidopsis thaliana"
xref: Reactome:REACT_85609 "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol, Taeniopygia guttata"
xref: Reactome:REACT_86519 "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol, Canis familiaris"
xref: Reactome:REACT_88988 "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol, Canis familiaris"
xref: Reactome:REACT_89551 "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol, Saccharomyces cerevisiae"
xref: Reactome:REACT_94158 "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol, Gallus gallus"
xref: Reactome:REACT_95387 "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol, Danio rerio"
xref: Reactome:REACT_95721 "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol, Dictyostelium discoideum"
xref: Reactome:REACT_96643 "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol, Rattus norvegicus"
xref: Reactome:REACT_97328 "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol, Bos taurus"
xref: Reactome:REACT_99679 "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol, Rattus norvegicus"
xref: Reactome:REACT_99766 "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol, Arabidopsis thaliana"
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0000255
name: allantoin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving allantoin, (2,5-dioxo-4-imidazolidinyl)urea, an intermediate or end product of purine catabolism." [GOC:mah, ISBN:0198547684]
subset: gosubset_prok
synonym: "allantoin metabolism" EXACT []
is_a: GO:0043603 ! cellular amide metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process

[Term]
id: GO:0000256
name: allantoin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of allantoin, (2,5-dioxo-4-imidazolidinyl)urea." [GOC:mah, ISBN:0198547684]
subset: gosubset_prok
synonym: "allantoin breakdown" EXACT []
synonym: "allantoin catabolism" EXACT []
synonym: "allantoin degradation" EXACT []
is_a: GO:0000255 ! allantoin metabolic process
is_a: GO:0043605 ! cellular amide catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process

[Term]
id: GO:0000257
name: nitrilase activity
namespace: molecular_function
def: "Catalysis of the reaction: a nitrile + H2O = a carboxylate + NH3. Acts on a wide range of aromatic nitriles including (indole-3-yl)-acetonitrile and some aliphatic nitriles, and on the corresponding acid amides." [EC:3.5.5.1, GOC:kd]
subset: gosubset_prok
synonym: "acetonitrilase activity" EXACT [EC:3.5.5.1]
synonym: "benzonitrilase activity" EXACT [EC:3.5.5.1]
synonym: "nitrile aminohydrolase activity" EXACT [EC:3.5.5.1]
xref: EC:3.5.5.1
xref: KEGG:R00540
xref: MetaCyc:3.5.5.1-RXN
xref: RHEA:21727
xref: UM-BBD_enzymeID:e0283
is_a: GO:0016815 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles

[Term]
id: GO:0000258
name: obsolete isoleucine/valine:sodium symporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (isoleucine or valine)(out) + Na+(out) = (isoleucine or valine)(in) + Na+(in)." [TC:2.A.26.1.1]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "isoleucine/valine:sodium symporter activity" EXACT []
is_obsolete: true
consider: GO:0005283
consider: GO:0005304
consider: GO:0015188

[Term]
id: GO:0000259
name: obsolete intracellular nucleoside transmembrane transporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose (a deoxyribonucleotide) within a cell." [GOC:ai]
comment: This term was made obsolete because it contains component and function information.
synonym: "intracellular nucleoside transmembrane transporter activity" EXACT []
is_obsolete: true
consider: GO:0005337
consider: GO:0005622

[Term]
id: GO:0000260
name: obsolete hydrogen-translocating V-type ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + H(+)(in) = ADP + phosphate + H+(out). Found in vacuoles of eukaryotes and in bacteria." [TC:3.A.2.2.1, TC:3.A.2.2.3]
comment: This term was made obsolete because it represents a gene product.
synonym: "hydrogen-translocating V-type ATPase activity" EXACT []
is_obsolete: true
replaced_by: GO:0046961

[Term]
id: GO:0000261
name: obsolete sodium-translocating V-type ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out). Found in vacuoles of eukaryotes and in bacteria." [TC:3.A.2.2.2]
comment: This term was made obsolete because it represents a gene product.
synonym: "sodium-translocating V-type ATPase activity" EXACT []
is_obsolete: true
replaced_by: GO:0046962

[Term]
id: GO:0000262
name: mitochondrial chromosome
namespace: cellular_component
def: "A chromosome found in the mitochondrion of a eukaryotic cell." [GOC:mah]
synonym: "mitochondrial DNA" NARROW []
synonym: "mitochondrial genome" RELATED []
synonym: "mtDNA" NARROW []
xref: NIF_Subcellular:sao1186327184
is_a: GO:0000229 ! cytoplasmic chromosome
is_a: GO:0044429 ! mitochondrial part
intersection_of: GO:0005694 ! chromosome
intersection_of: part_of GO:0005739 ! mitochondrion
relationship: part_of GO:0005739 ! mitochondrion
relationship: part_of GO:0042645 ! mitochondrial nucleoid

[Term]
id: GO:0000263
name: obsolete heterotrimeric G-protein GTPase, alpha-subunit
namespace: molecular_function
def: "OBSOLETE. Subunit of a heterotrimeric G-protein GTPase that contains the guanine nucleotide binding site and possesses GTPase activity." [GOC:mah, ISBN:0198547684]
comment: This term was made obsolete because it does not represent a molecular function.
synonym: "heterotrimeric G-protein GTPase, alpha-subunit" EXACT []
is_obsolete: true
consider: GO:0003924
consider: GO:0005834

[Term]
id: GO:0000264
name: obsolete heterotrimeric G-protein GTPase, beta-subunit
namespace: molecular_function
def: "OBSOLETE. Subunit of a heterotrimeric G-protein GTPase; associates tightly with the gamma subunit." [GOC:mah, ISBN:0198547684]
comment: This term was made obsolete because it does not represent a molecular function.
synonym: "heterotrimeric G-protein GTPase, beta-subunit" EXACT []
is_obsolete: true
consider: GO:0003924
consider: GO:0005834

[Term]
id: GO:0000265
name: obsolete heterotrimeric G-protein GTPase, gamma-subunit
namespace: molecular_function
def: "OBSOLETE. Smallest subunit of a heterotrimeric G-protein GTPase; associates tightly with the beta subunit." [GOC:mah, ISBN:0198547684]
comment: This term was made obsolete because it does not represent a molecular function.
synonym: "heterotrimeric G-protein GTPase, gamma-subunit" EXACT []
is_obsolete: true
consider: GO:0003924
consider: GO:0005834

[Term]
id: GO:0000266
name: mitochondrial fission
namespace: biological_process
def: "The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [PMID:11038192]
synonym: "mitochondrial division" EXACT []
synonym: "mitochondrial proliferation" RELATED []
is_a: GO:0007005 ! mitochondrion organization
is_a: GO:0048285 ! organelle fission

[Term]
id: GO:0000267
name: obsolete cell fraction
namespace: cellular_component
def: "OBSOLETE: A generic term for parts of cells prepared by disruptive biochemical techniques." [GOC:ma]
comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component.
subset: goslim_pir
subset: gosubset_prok
synonym: "cell fraction" EXACT []
is_obsolete: true
consider: GO:0005575

[Term]
id: GO:0000268
name: peroxisome targeting sequence binding
namespace: molecular_function
alt_id: GO:0005051
def: "Interacting selectively and non-covalently with a peroxisomal targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome." [GOC:mah, ISBN:0879693568]
synonym: "peroxisome targeting signal receptor" NARROW []
synonym: "PTS binding" EXACT []
synonym: "PTS receptor" NARROW []
is_a: GO:0005048 ! signal sequence binding

[Term]
id: GO:0000269
name: toxin export channel activity
namespace: molecular_function
def: "Enables the energy independent passage of toxins, sized less than 1000 Da, across a membrane towards the outside of the cell. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport]
is_a: GO:0015288 ! porin activity
is_a: GO:0019534 ! toxin transporter activity

[Term]
id: GO:0000270
name: peptidoglycan metabolic process
namespace: biological_process
alt_id: GO:0009284
def: "The chemical reactions and pathways involving peptidoglycans, any of a class of glycoconjugates found only in bacterial cell walls and consisting of strands of glycosaminoglycan cross-linked by oligopeptides to form a huge and rigid network." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732]
subset: gosubset_prok
synonym: "murein metabolic process" EXACT []
synonym: "murein metabolism" EXACT []
synonym: "peptidoglycan metabolism" EXACT []
is_a: GO:0030203 ! glycosaminoglycan metabolic process

[Term]
id: GO:0000271
name: polysaccharide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [CHEBI:18154, GOC:go_curators]
subset: gosubset_prok
synonym: "glycan biosynthesis" EXACT []
synonym: "glycan biosynthetic process" EXACT []
synonym: "polysaccharide anabolism" EXACT []
synonym: "polysaccharide biosynthesis" EXACT []
synonym: "polysaccharide formation" EXACT []
synonym: "polysaccharide synthesis" EXACT []
is_a: GO:0005976 ! polysaccharide metabolic process
is_a: GO:0009059 ! macromolecule biosynthetic process
is_a: GO:0016051 ! carbohydrate biosynthetic process

[Term]
id: GO:0000272
name: polysaccharide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [CHEBI:18154, GOC:go_curators]
subset: gosubset_prok
synonym: "polysaccharide breakdown" EXACT []
synonym: "polysaccharide catabolism" EXACT []
synonym: "polysaccharide degradation" EXACT []
is_a: GO:0005976 ! polysaccharide metabolic process
is_a: GO:0009057 ! macromolecule catabolic process
is_a: GO:0016052 ! carbohydrate catabolic process

[Term]
id: GO:0000274
name: mitochondrial proton-transporting ATP synthase, stator stalk
namespace: cellular_component
def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the mitochondrial membrane-associated F0 proteins; is thought to prevent futile rotation of the catalytic core." [GOC:mtg_sensu, PMID:10838056]
synonym: "mitochondrial proton-transporting ATP synthase, peripheral stalk" EXACT []
is_a: GO:0045265 ! proton-transporting ATP synthase, stator stalk
is_a: GO:0098800 ! inner mitochondrial membrane protein complex
intersection_of: GO:0045265 ! proton-transporting ATP synthase, stator stalk
intersection_of: part_of GO:0005739 ! mitochondrion
relationship: part_of GO:0000276 ! mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
relationship: part_of GO:0005739 ! mitochondrion

[Term]
id: GO:0000275
name: mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)
namespace: cellular_component
def: "The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the mitochondrial inner membrane when the entire ATP synthase is assembled." [GOC:mtg_sensu, PMID:10838056]
comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'.
synonym: "hydrogen-transporting ATP synthase, F1 sector" BROAD []
synonym: "proton-transporting ATP synthase complex, catalytic core F(1)" BROAD []
is_a: GO:0045261 ! proton-transporting ATP synthase complex, catalytic core F(1)
is_a: GO:0098800 ! inner mitochondrial membrane protein complex
intersection_of: GO:0045261 ! proton-transporting ATP synthase complex, catalytic core F(1)
intersection_of: part_of GO:0005739 ! mitochondrion
relationship: part_of GO:0005739 ! mitochondrion
relationship: part_of GO:0005753 ! mitochondrial proton-transporting ATP synthase complex

[Term]
id: GO:0000276
name: mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
namespace: cellular_component
def: "All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins." [GOC:mtg_sensu, PMID:10838056]
is_a: GO:0045263 ! proton-transporting ATP synthase complex, coupling factor F(o)
is_a: GO:0098800 ! inner mitochondrial membrane protein complex
intersection_of: GO:0045263 ! proton-transporting ATP synthase complex, coupling factor F(o)
intersection_of: part_of GO:0005739 ! mitochondrion
relationship: part_of GO:0005739 ! mitochondrion
relationship: part_of GO:0005753 ! mitochondrial proton-transporting ATP synthase complex

[Term]
id: GO:0000277
name: [cytochrome c]-lysine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + cytochrome c L-lysine = S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine. This is the addition of a methyl group to the N6 atom of a lysine residue in cytochrome c." [EC:2.1.1.59]
synonym: "cytochrome c (lysine) methyltransferase activity" EXACT [EC:2.1.1.59]
synonym: "cytochrome c methyltransferase activity" EXACT [EC:2.1.1.59]
synonym: "cytochrome c-lysine N-methyltransferase activity" EXACT [EC:2.1.1.59]
synonym: "cytochrome c-specific protein methylase III activity" EXACT [EC:2.1.1.59]
synonym: "cytochrome c-specific protein-lysine methyltransferase activity" EXACT [EC:2.1.1.59]
synonym: "S-adenosyl-L-methionine:cytochrome c-L-lysine 6-N-methyltransferase activity" EXACT [EC:2.1.1.59]
synonym: "S-adenosyl-L-methionine:cytochrome c-L-lysine N6-methyltransferase activity" EXACT [EC:2.1.1.59]
xref: EC:2.1.1.59
xref: MetaCyc:2.1.1.59-RXN
is_a: GO:0016279 ! protein-lysine N-methyltransferase activity

[Term]
id: GO:0000278
name: mitotic cell cycle
namespace: biological_process
def: "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]
subset: goslim_yeast
xref: Reactome:REACT_100451 "Cell Cycle, Mitotic, Taeniopygia guttata"
xref: Reactome:REACT_104035 "Cell Cycle, Mitotic, Sus scrofa"
xref: Reactome:REACT_104195 "Cell Cycle, Mitotic, Canis familiaris"
xref: Reactome:REACT_105856 "Cell Cycle, Mitotic, Danio rerio"
xref: Reactome:REACT_108233 "Cell Cycle, Mitotic, Saccharomyces cerevisiae"
xref: Reactome:REACT_152 "Cell Cycle, Mitotic, Homo sapiens"
xref: Reactome:REACT_28464 "Cell Cycle, Mitotic, Xenopus tropicalis"
xref: Reactome:REACT_28953 "Cell Cycle, Mitotic, Bos taurus"
xref: Reactome:REACT_33388 "Cell Cycle, Mitotic, Rattus norvegicus"
xref: Reactome:REACT_53493 "Cell Cycle, Mitotic, Plasmodium falciparum"
xref: Reactome:REACT_79085 "Cell Cycle, Mitotic, Schizosaccharomyces pombe"
xref: Reactome:REACT_84794 "Cell Cycle, Mitotic, Caenorhabditis elegans"
xref: Reactome:REACT_85137 "Cell Cycle, Mitotic, Gallus gallus"
xref: Reactome:REACT_85950 "Cell Cycle, Mitotic, Arabidopsis thaliana"
xref: Reactome:REACT_90332 "Cell Cycle, Mitotic, Mus musculus"
xref: Reactome:REACT_90846 "Cell Cycle, Mitotic, Oryza sativa"
xref: Reactome:REACT_96281 "Cell Cycle, Mitotic, Drosophila melanogaster"
xref: Reactome:REACT_97744 "Cell Cycle, Mitotic, Dictyostelium discoideum"
xref: Reactome:REACT_98208 "Cell Cycle, Mitotic, Mycobacterium tuberculosis"
is_a: GO:0007049 ! cell cycle
intersection_of: GO:0007049 ! cell cycle
intersection_of: has_part GO:0007067 ! mitotic nuclear division
relationship: has_part GO:0007067 ! mitotic nuclear division

[Term]
id: GO:0000279
name: M phase
namespace: biological_process
def: "A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "M-phase" EXACT []
xref: Wikipedia:M_phase
is_a: GO:0022403 ! cell cycle phase

[Term]
id: GO:0000280
name: nuclear division
namespace: biological_process
def: "The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei." [GOC:mah]
subset: goslim_pir
synonym: "karyokinesis" RELATED []
is_a: GO:0048285 ! organelle fission

[Term]
id: GO:0000281
name: mitotic cytokinesis
namespace: biological_process
def: "A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]
subset: goslim_pombe
synonym: "cytokinesis after mitosis" EXACT []
is_a: GO:0061640 ! cytoskeleton-dependent cytokinesis
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0061640 ! cytoskeleton-dependent cytokinesis
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0000282
name: cellular bud site selection
namespace: biological_process
def: "The specification of the site where a daughter cell will form, in organisms that reproduce by budding. An example of this process is found in Saccharomyces cerevisiae." [GOC:mah]
comment: Note that this term was split from 'bud site selection/establishment of cell polarity (sensu Saccharomyces) ; GO:0007115' (a sibling term, 'establishment of cell polarity (sensu Saccharomyces) ; GO:0000283', was created but has since been merged with 'establishment of cell polarity' ; GO:0030010).
synonym: "bud site selection/establishment of cell polarity" BROAD []
is_a: GO:0030010 ! establishment of cell polarity
is_a: GO:1902408 ! mitotic cytokinesis, site selection
relationship: part_of GO:0000281 ! mitotic cytokinesis

[Term]
id: GO:0000284
name: obsolete shmoo orientation
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh]
comment: This term was made obsolete because it is an organism specific term. The entire branch of the ontology was reorganized to be more generally applicable.
synonym: "shmoo orientation" EXACT []
is_obsolete: true
replaced_by: GO:0000753

[Term]
id: GO:0000285
name: 1-phosphatidylinositol-3-phosphate 5-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.150, RHEA:13612]
synonym: "ATP:1-phosphatidyl-1D-myo-inositol-3-phosphate 5-phosphotransferase activity" EXACT [EC:2.7.1.150]
synonym: "phosphatidylinositol 3-phosphate 5-kinase activity" EXACT [EC:2.7.1.150]
synonym: "phosphatidylinositol-3-phosphate 5-kinase activity" EXACT []
synonym: "type III PIP kinase activity" RELATED [EC:2.7.1.150]
xref: EC:2.7.1.150
xref: KEGG:R05802
xref: MetaCyc:2.7.1.150-RXN
xref: RHEA:13612
is_a: GO:0016307 ! phosphatidylinositol phosphate kinase activity

[Term]
id: GO:0000286
name: alanine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-alanine + H2O + NAD+ = pyruvate + NH3 + NADH + H(+)." [EC:1.4.1.1]
subset: gosubset_prok
synonym: "AlaDH" RELATED [EC:1.4.1.1]
synonym: "alanine oxidoreductase activity" EXACT [EC:1.4.1.1]
synonym: "alpha-alanine dehydrogenase activity" EXACT [EC:1.4.1.1]
synonym: "L-alanine dehydrogenase activity" EXACT [EC:1.4.1.1]
synonym: "L-alanine:NAD+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.1]
synonym: "NAD-dependent alanine dehydrogenase activity" EXACT [EC:1.4.1.1]
synonym: "NAD-linked alanine dehydrogenase activity" EXACT [EC:1.4.1.1]
synonym: "NADH-dependent alanine dehydrogenase activity" EXACT [EC:1.4.1.1]
xref: EC:1.4.1.1
xref: MetaCyc:ALANINE-DEHYDROGENASE-RXN
xref: RHEA:18408
is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors

[Term]
id: GO:0000287
name: magnesium ion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]
subset: gosubset_prok
synonym: "magnesium binding" EXACT []
is_a: GO:0046872 ! metal ion binding

[Term]
id: GO:0000288
name: nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
namespace: biological_process
def: "A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability." [GOC:jp, GOC:krc]
synonym: "deadenylation-dependent mRNA decay" EXACT []
synonym: "mRNA breakdown, deadenylation-dependent decay" EXACT []
synonym: "mRNA catabolic process, deadenylation-dependent" EXACT []
synonym: "mRNA catabolic process, deadenylylation-dependent" EXACT []
synonym: "mRNA catabolism, deadenylation-dependent" EXACT []
synonym: "mRNA catabolism, deadenylylation-dependent" EXACT []
synonym: "mRNA degradation, deadenylation-dependent decay" EXACT []
synonym: "nuclear mRNA catabolic process, deadenylation-dependent decay" EXACT []
xref: Reactome:REACT_102357 "Deadenylation-dependent mRNA decay, Xenopus tropicalis"
xref: Reactome:REACT_103296 "Deadenylation-dependent mRNA decay, Gallus gallus"
xref: Reactome:REACT_105200 "Deadenylation-dependent mRNA decay, Plasmodium falciparum"
xref: Reactome:REACT_110041 "Deadenylation-dependent mRNA decay, Caenorhabditis elegans"
xref: Reactome:REACT_20639 "Deadenylation-dependent mRNA decay, Homo sapiens"
xref: Reactome:REACT_49520 "Deadenylation-dependent mRNA decay, Rattus norvegicus"
xref: Reactome:REACT_79530 "Deadenylation-dependent mRNA decay, Saccharomyces cerevisiae"
xref: Reactome:REACT_82315 "Deadenylation-dependent mRNA decay, Sus scrofa"
xref: Reactome:REACT_83961 "Deadenylation-dependent mRNA decay, Schizosaccharomyces pombe"
xref: Reactome:REACT_89647 "Deadenylation-dependent mRNA decay, Drosophila melanogaster"
xref: Reactome:REACT_90397 "Deadenylation-dependent mRNA decay, Mus musculus"
xref: Reactome:REACT_93483 "Deadenylation-dependent mRNA decay, Taeniopygia guttata"
xref: Reactome:REACT_95045 "Deadenylation-dependent mRNA decay, Oryza sativa"
xref: Reactome:REACT_95337 "Deadenylation-dependent mRNA decay, Arabidopsis thaliana"
xref: Reactome:REACT_96238 "Deadenylation-dependent mRNA decay, Dictyostelium discoideum"
xref: Reactome:REACT_96993 "Deadenylation-dependent mRNA decay, Bos taurus"
xref: Reactome:REACT_97186 "Deadenylation-dependent mRNA decay, Canis familiaris"
xref: Reactome:REACT_99680 "Deadenylation-dependent mRNA decay, Danio rerio"
is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process

[Term]
id: GO:0000289
name: nuclear-transcribed mRNA poly(A) tail shortening
namespace: biological_process
def: "Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length." [GOC:krc]
synonym: "3' to 5' mRNA deadenylation" RELATED []
synonym: "mRNA deadenylation" RELATED []
synonym: "nuclear mRNA poly(A) tail shortening" RELATED []
xref: Reactome:REACT_102415 "Deadenylation of mRNA, Rattus norvegicus"
xref: Reactome:REACT_104397 "Deadenylation of mRNA, Danio rerio"
xref: Reactome:REACT_109691 "Deadenylation of mRNA, Bos taurus"
xref: Reactome:REACT_111968 "Deadenylation of mRNA, Drosophila melanogaster"
xref: Reactome:REACT_20514 "Deadenylation of mRNA, Homo sapiens"
xref: Reactome:REACT_30693 "Deadenylation of mRNA, Xenopus tropicalis"
xref: Reactome:REACT_31579 "Deadenylation of mRNA, Canis familiaris"
xref: Reactome:REACT_78492 "Deadenylation of mRNA, Mus musculus"
xref: Reactome:REACT_83021 "Deadenylation of mRNA, Taeniopygia guttata"
is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process
relationship: part_of GO:0000288 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

[Term]
id: GO:0000290
name: deadenylation-dependent decapping of nuclear-transcribed mRNA
namespace: biological_process
def: "Cleavage of the 5'-cap of a nuclear mRNA triggered by shortening of the poly(A) tail to below a minimum functional length." [GOC:krc]
synonym: "deadenylation-dependent decapping of nuclear mRNA" EXACT []
synonym: "deadenylylation-dependent decapping" EXACT []
is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process
relationship: part_of GO:0000288 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

[Term]
id: GO:0000291
name: nuclear-transcribed mRNA catabolic process, exonucleolytic
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5'-cap or the 3'-poly(A) tail." [GOC:krc]
synonym: "exonucleolytic degradation of mRNA" EXACT []
synonym: "mRNA breakdown, exonucleolytic" EXACT []
synonym: "mRNA degradation, exonucleolytic" EXACT []
synonym: "nuclear mRNA catabolic process, exonucleolytic" EXACT []
is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process

[Term]
id: GO:0000292
name: RNA fragment catabolic process
namespace: biological_process
alt_id: GO:0030452
def: "The chemical reactions and pathways resulting in the breakdown of a fragment of RNA, such as excised introns or sequences removed from ribosomal RNA during processing." [GOC:mah]
subset: gosubset_prok
synonym: "group I intron catabolic process" NARROW []
synonym: "RNA fragment breakdown" EXACT []
synonym: "RNA fragment catabolism" EXACT [GOC:mah]
synonym: "RNA fragment degradation" EXACT []
is_a: GO:0006401 ! RNA catabolic process

[Term]
id: GO:0000293
name: ferric-chelate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 Fe2+ + NAD+ = 2 Fe3+ + NADH + H(+)." [EC:1.16.1.7]
comment: Note that this function was formerly EC:1.6.99.13.
synonym: "Fe(II):NAD+ oxidoreductase activity" EXACT [EC:1.16.1.7]
synonym: "ferric chelate reductase activity" EXACT [EC:1.16.1.7]
synonym: "iron chelate reductase activity" RELATED [EC:1.16.1.7]
synonym: "NADH2:Fe3+ oxidoreductase activity" EXACT [EC:1.16.1.7]
synonym: "NADH:Fe(3+) oxidoreductase activity" EXACT [EC:1.16.1.7]
synonym: "NADH:Fe(3+)-EDTA reductase activity" EXACT [EC:1.16.1.7]
synonym: "NADH:Fe3+ oxidoreductase activity" EXACT [EC:1.16.1.7]
synonym: "NADH:Fe3+-EDTA reductase activity" EXACT [EC:1.16.1.7]
xref: EC:1.16.1.7
xref: MetaCyc:FERRIC-CHELATE-REDUCTASE-RXN
xref: RHEA:15064
is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor

[Term]
id: GO:0000294
name: nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay
namespace: biological_process
def: "A minor degradation pathway nuclear-transcribed mRNAs that begins with an endonucleolytic cleavage to generate unprotected ends." [GOC:krc]
synonym: "endonucleolytic mRNA decay" EXACT []
synonym: "mRNA breakdown, endonucleolytic cleavage-dependent decay" EXACT []
synonym: "mRNA catabolic process, endonucleolytic" EXACT []
synonym: "mRNA catabolism, endonucleolytic" EXACT []
synonym: "mRNA degradation, endonucleolytic cleavage-dependent decay" EXACT []
synonym: "nuclear mRNA catabolic process, endonucleolytic cleavage-dependent decay" EXACT []
is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process

[Term]
id: GO:0000295
name: adenine nucleotide transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of adenine nucleotides (AMP, ADP, and ATP) from one side of the membrane to the other." [PMID:11566870]
xref: Reactome:REACT_101864 "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP, Bos taurus"
xref: Reactome:REACT_107442 "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP, Rattus norvegicus"
xref: Reactome:REACT_113419 "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP, Oryza sativa"
xref: Reactome:REACT_16948 "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP, Homo sapiens"
xref: Reactome:REACT_28950 "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP, Mus musculus"
xref: Reactome:REACT_30244 "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP, Drosophila melanogaster"
xref: Reactome:REACT_33254 "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP, Dictyostelium discoideum"
xref: Reactome:REACT_80715 "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP, Taeniopygia guttata"
xref: Reactome:REACT_83323 "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP, Gallus gallus"
xref: Reactome:REACT_85299 "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP, Saccharomyces cerevisiae"
xref: Reactome:REACT_86138 "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP, Canis familiaris"
xref: Reactome:REACT_86805 "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP, Danio rerio"
xref: Reactome:REACT_89005 "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP, Sus scrofa"
xref: Reactome:REACT_91614 "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP, Xenopus tropicalis"
is_a: GO:0015216 ! purine nucleotide transmembrane transporter activity
relationship: part_of GO:0051503 ! adenine nucleotide transport

[Term]
id: GO:0000296
name: spermine transport
namespace: biological_process
def: "The directed movement of spermine, N,N-bis(3-aminopropyl)-1,4-diaminobutane, a polyamine formed by the transfer of a propylamine group from decarboxylated S-adenosylmethionine to spermidine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc, ISBN:0198506732]
is_a: GO:0015696 ! ammonium transport
is_a: GO:0015846 ! polyamine transport

[Term]
id: GO:0000297
name: spermine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of spermine from one side of the membrane to the other. Spermine is a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication." [GOC:ai]
is_a: GO:0008519 ! ammonium transmembrane transporter activity
is_a: GO:0015203 ! polyamine transmembrane transporter activity
relationship: part_of GO:1903710 ! spermine transmembrane transport

[Term]
id: GO:0000298
name: endopolyphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: polyphosphate + n H2O = (n+1) oligophosphate. The product contains 4 or 5 phosphate residues." [EC:3.6.1.10]
synonym: "metaphosphatase activity" BROAD [EC:3.6.1.10]
synonym: "polymetaphosphatase activity" EXACT [EC:3.6.1.10]
synonym: "polyphosphatase activity" BROAD [EC:3.6.1.10]
synonym: "polyphosphate depolymerase activity" BROAD [EC:3.6.1.10]
synonym: "polyphosphate polyphosphohydrolase activity" EXACT [EC:3.6.1.10]
xref: EC:3.6.1.10
xref: MetaCyc:ENDOPOLYPHOSPHATASE-RXN
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0000299
name: obsolete integral to membrane of membrane fraction
namespace: cellular_component
def: "OBSOLETE: Integral to that fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes; require detergents, such as Triton X-100, to be released from membranes." [PMID:10512869]
comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component.
synonym: "integral to membrane of membrane fraction" EXACT []
is_obsolete: true
consider: GO:0016021

[Term]
id: GO:0000300
name: obsolete peripheral to membrane of membrane fraction
namespace: cellular_component
def: "OBSOLETE: Peripheral to that fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes; can be extracted from membrane fraction with high concentrations of salt or high pH." [PMID:10512869]
comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component.
synonym: "peripheral to membrane of membrane fraction" EXACT []
is_obsolete: true
consider: GO:0019898

[Term]
id: GO:0000301
name: retrograde transport, vesicle recycling within Golgi
namespace: biological_process
def: "The retrograde movement of substances within the Golgi, mediated by COP I vesicles. Cis-Golgi vesicles are constantly moving forward through the Golgi stack by cisternal progression, eventually becoming trans-Golgi vesicles. They then selectively transport membrane and luminal proteins from the trans- to the medial-Golgi while leaving others behind in the trans-Golgi cisternae; similarly, they selectively move proteins from the medial- to the cis-Golgi." [ISBN:0716731363]
synonym: "retrograde (vesicle recycling within Golgi) transport" EXACT []
is_a: GO:0006891 ! intra-Golgi vesicle-mediated transport

[Term]
id: GO:0000302
name: response to reactive oxygen species
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:krc]
subset: gosubset_prok
synonym: "response to active oxygen species" EXACT []
synonym: "response to AOS" EXACT []
synonym: "response to reactive oxidative species" EXACT []
synonym: "response to reactive oxygen intermediate" EXACT []
synonym: "response to ROI" EXACT []
synonym: "response to ROS" EXACT []
is_a: GO:0006979 ! response to oxidative stress
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0000303
name: response to superoxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion." [GOC:krc, ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0000305 ! response to oxygen radical

[Term]
id: GO:0000304
name: response to singlet oxygen
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a singlet oxygen stimulus. Singlet oxygen is a dioxygen (O2) molecule in which two 2p electrons have similar spin. Singlet oxygen is more highly reactive than the form in which these electrons are of opposite spin, and it is produced in mutant chloroplasts lacking carotenoids and by leukocytes during metabolic burst." [GOC:krc, ISBN:0124325653, ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0000302 ! response to reactive oxygen species
is_a: GO:0010035 ! response to inorganic substance

[Term]
id: GO:0000305
name: response to oxygen radical
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen radical stimulus. An oxygen radical is any oxygen species that carries a free electron; examples include hydroxyl radicals and the superoxide anion." [GOC:krc, ISBN:0124325653]
subset: gosubset_prok
is_a: GO:0000302 ! response to reactive oxygen species
is_a: GO:0010035 ! response to inorganic substance

[Term]
id: GO:0000306
name: extrinsic component of vacuolar membrane
namespace: cellular_component
def: "The component of a vacuolar membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah]
synonym: "extrinsic to vacuolar membrane" EXACT []
is_a: GO:0031312 ! extrinsic component of organelle membrane
is_a: GO:0044437 ! vacuolar part
intersection_of: GO:0019898 ! extrinsic component of membrane
intersection_of: part_of GO:0005774 ! vacuolar membrane
relationship: part_of GO:0005774 ! vacuolar membrane

[Term]
id: GO:0000307
name: cyclin-dependent protein kinase holoenzyme complex
namespace: cellular_component
def: "Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner." [GOC:krc, PMID:11602261]
subset: goslim_pir
synonym: "CDK holoenzyme" EXACT []
is_a: GO:0044424 ! intracellular part
is_a: GO:1902554 ! serine/threonine protein kinase complex

[Term]
id: GO:0000308
name: cytoplasmic cyclin-dependent protein kinase holoenzyme complex
namespace: cellular_component
def: "Cyclin-dependent protein kinase (CDK) complex found in the cytoplasm." [GOC:krc]
synonym: "CDK holoenzyme" BROAD []
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex
is_a: GO:0044444 ! cytoplasmic part
intersection_of: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex
intersection_of: part_of GO:0005737 ! cytoplasm
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0000309
name: nicotinamide-nucleotide adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + nicotinamide nucleotide = diphosphate + NAD+." [EC:2.7.7.1]
subset: gosubset_prok
synonym: "adenosine triphosphate-nicotinamide mononucleotide transadenylase activity" EXACT [EC:2.7.7.1]
synonym: "ATP:nicotinamide-nucleotide adenylyltransferase activity" EXACT []
synonym: "ATP:NMN adenylyltransferase activity" EXACT [EC:2.7.7.1]
synonym: "diphosphopyridine nucleotide pyrophosphorylase activity" RELATED [EC:2.7.7.1]
synonym: "NAD(+) diphosphorylase activity" NARROW [EC:2.7.7.1]
synonym: "NAD(+) pyrophosphorylase activity" NARROW [EC:2.7.7.1]
synonym: "NAD+ diphosphorylase activity" EXACT [EC:2.7.7.1]
synonym: "NAD+ pyrophosphorylase activity" EXACT [EC:2.7.7.1]
synonym: "nicotinamide adenine dinucleotide pyrophosphorylase activity" NARROW [EC:2.7.7.1]
synonym: "nicotinamide mononucleotide adenylyltransferase activity" NARROW [EC:2.7.7.1]
synonym: "NMN adenylyltransferase activity" NARROW [EC:2.7.7.1]
synonym: "NMNAT activity" NARROW [EC:2.7.7.1]
xref: EC:2.7.7.1
xref: MetaCyc:2.7.7.1-RXN
xref: Reactome:REACT_101807 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3], Sus scrofa"
xref: Reactome:REACT_102033 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2], Canis familiaris"
xref: Reactome:REACT_103802 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2], Mus musculus"
xref: Reactome:REACT_105839 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT1], Xenopus tropicalis"
xref: Reactome:REACT_107769 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3], Canis familiaris"
xref: Reactome:REACT_107952 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3], Drosophila melanogaster"
xref: Reactome:REACT_108630 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT1], Sus scrofa"
xref: Reactome:REACT_108997 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2], Sus scrofa"
xref: Reactome:REACT_11116 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2], Homo sapiens"
xref: Reactome:REACT_11196 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3], Homo sapiens"
xref: Reactome:REACT_112138 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2], Arabidopsis thaliana"
xref: Reactome:REACT_11237 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT1], Homo sapiens"
xref: Reactome:REACT_112385 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2], Oryza sativa"
xref: Reactome:REACT_114383 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3], Dictyostelium discoideum"
xref: Reactome:REACT_114560 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2], Schizosaccharomyces pombe"
xref: Reactome:REACT_114828 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2], Saccharomyces cerevisiae"
xref: Reactome:REACT_115028 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT1], Dictyostelium discoideum"
xref: Reactome:REACT_29972 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2], Caenorhabditis elegans"
xref: Reactome:REACT_30979 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT1], Oryza sativa"
xref: Reactome:REACT_31171 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT1], Arabidopsis thaliana"
xref: Reactome:REACT_31453 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT1], Taeniopygia guttata"
xref: Reactome:REACT_70840 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3], Saccharomyces cerevisiae"
xref: Reactome:REACT_77837 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3], Oryza sativa"
xref: Reactome:REACT_78904 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2], Dictyostelium discoideum"
xref: Reactome:REACT_79519 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2], Rattus norvegicus"
xref: Reactome:REACT_79745 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3], Danio rerio"
xref: Reactome:REACT_79909 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT1], Canis familiaris"
xref: Reactome:REACT_80724 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3], Schizosaccharomyces pombe"
xref: Reactome:REACT_80917 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2], Danio rerio"
xref: Reactome:REACT_81520 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2], Taeniopygia guttata"
xref: Reactome:REACT_81532 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT1], Bos taurus"
xref: Reactome:REACT_83285 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT1], Mus musculus"
xref: Reactome:REACT_84119 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3], Mus musculus"
xref: Reactome:REACT_86854 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2], Xenopus tropicalis"
xref: Reactome:REACT_90006 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT1], Saccharomyces cerevisiae"
xref: Reactome:REACT_92077 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3], Gallus gallus"
xref: Reactome:REACT_93517 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT1], Drosophila melanogaster"
xref: Reactome:REACT_95186 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3], Rattus norvegicus"
xref: Reactome:REACT_96395 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT1], Schizosaccharomyces pombe"
xref: Reactome:REACT_96707 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2], Gallus gallus"
xref: Reactome:REACT_97201 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT1], Rattus norvegicus"
xref: Reactome:REACT_97323 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3], Taeniopygia guttata"
xref: Reactome:REACT_97434 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3], Arabidopsis thaliana"
xref: Reactome:REACT_98853 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2], Bos taurus"
xref: RHEA:21363
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0000310
name: xanthine phosphoribosyltransferase activity
namespace: molecular_function
alt_id: GO:0009043
def: "Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + xanthine = (9-D-ribosylxanthine)-5'-phosphate + diphosphate." [EC:2.4.2.22, GOC:clt]
subset: gosubset_prok
synonym: "5-phospho-alpha-D-ribose-1-diphosphate:xanthine phospho-D-ribosyltransferase activity" EXACT [EC:2.4.2.22]
synonym: "Xan phosphoribosyltransferase activity" EXACT [EC:2.4.2.22]
synonym: "xanthine-guanine phosphoribosyltransferase activity" EXACT []
synonym: "xanthosine 5'-phosphate pyrophosphorylase activity" EXACT [EC:2.4.2.22]
synonym: "xanthylate pyrophosphorylase activity" EXACT [EC:2.4.2.22]
synonym: "xanthylic pyrophosphorylase activity" EXACT [EC:2.4.2.22]
synonym: "XMP pyrophosphorylase activity" EXACT [EC:2.4.2.22]
synonym: "XMP:diphosphate 5-phospho-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.22]
xref: EC:2.4.2.22
xref: MetaCyc:XANPRIBOSYLTRAN-RXN
xref: RHEA:10803
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0000311
name: plastid large ribosomal subunit
namespace: cellular_component
def: "The larger of the two subunits of a plastid ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc]
is_a: GO:0000315 ! organellar large ribosomal subunit
is_a: GO:0044435 ! plastid part
intersection_of: GO:0015934 ! large ribosomal subunit
intersection_of: part_of GO:0009547 ! plastid ribosome
relationship: part_of GO:0009547 ! plastid ribosome

[Term]
id: GO:0000312
name: plastid small ribosomal subunit
namespace: cellular_component
def: "The smaller of the two subunits of a plastid ribosome." [GOC:mcc]
is_a: GO:0000314 ! organellar small ribosomal subunit
is_a: GO:0044435 ! plastid part
intersection_of: GO:0015935 ! small ribosomal subunit
intersection_of: part_of GO:0009547 ! plastid ribosome
relationship: part_of GO:0009547 ! plastid ribosome

[Term]
id: GO:0000313
name: organellar ribosome
namespace: cellular_component
def: "A ribosome contained within a subcellular membrane-bounded organelle." [GOC:mah, GOC:mcc]
is_a: GO:0005840 ! ribosome
is_a: GO:0044422 ! organelle part
intersection_of: GO:0005840 ! ribosome
intersection_of: part_of GO:0043226 ! organelle
relationship: part_of GO:0043226 ! organelle

[Term]
id: GO:0000314
name: organellar small ribosomal subunit
namespace: cellular_component
def: "The smaller of the two subunits of an organellar ribosome." [GOC:mcc]
is_a: GO:0015935 ! small ribosomal subunit
intersection_of: GO:0015935 ! small ribosomal subunit
intersection_of: part_of GO:0000313 ! organellar ribosome
relationship: part_of GO:0000313 ! organellar ribosome

[Term]
id: GO:0000315
name: organellar large ribosomal subunit
namespace: cellular_component
def: "The larger of the two subunits of an organellar ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc]
is_a: GO:0015934 ! large ribosomal subunit
intersection_of: GO:0015934 ! large ribosomal subunit
intersection_of: part_of GO:0000313 ! organellar ribosome
relationship: part_of GO:0000313 ! organellar ribosome

[Term]
id: GO:0000316
name: sulfite transport
namespace: biological_process
def: "The directed movement of sulfite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
synonym: "sulphite transport" EXACT []
is_a: GO:0015698 ! inorganic anion transport
is_a: GO:0072348 ! sulfur compound transport

[Term]
id: GO:0000319
name: sulfite transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of sulfite ions from one side of a membrane to the other." [GOC:as]
synonym: "sulphite transporter activity" EXACT []
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity
is_a: GO:1901682 ! sulfur compound transmembrane transporter activity

[Term]
id: GO:0000320
name: re-entry into mitotic cell cycle
namespace: biological_process
def: "The resumption of the mitotic cell division cycle by cells that were in a quiescent or other non-dividing state." [GOC:krc]
is_a: GO:0022402 ! cell cycle process

[Term]
id: GO:0000321
name: re-entry into mitotic cell cycle after pheromone arrest
namespace: biological_process
def: "The resumption of the mitotic cell division cycle by pheromone-arrested cells that have not mated. An example of this process is found in Saccharomyces cerevisiae." [GOC:krc, PMID:9927449]
is_a: GO:0000320 ! re-entry into mitotic cell cycle
is_a: GO:0000754 ! adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion
is_a: GO:0044702 ! single organism reproductive process

[Term]
id: GO:0000322
name: storage vacuole
namespace: cellular_component
def: "A vacuole that functions primarily in the storage of materials, including nutrients, pigments, waste products, and small molecules." [GOC:krc]
is_a: GO:0005773 ! vacuole

[Term]
id: GO:0000323
name: lytic vacuole
namespace: cellular_component
def: "A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases." [GOC:krc]
is_a: GO:0005773 ! vacuole

[Term]
id: GO:0000324
name: fungal-type vacuole
namespace: cellular_component
def: "A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure." [GOC:mah, GOC:mtg_sensu, ISBN:0879693649]
synonym: "vacuole, cell cycle-correlated morphology" EXACT []
is_a: GO:0000322 ! storage vacuole
is_a: GO:0000323 ! lytic vacuole

[Term]
id: GO:0000325
name: plant-type vacuole
namespace: cellular_component
def: "A closed structure that is completely surrounded by a unit membrane, contains liquid, and retains the same shape regardless of cell cycle phase. An example of this structure is found in Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:0815316208]
synonym: "vacuole, cell cycle-independent morphology" EXACT []
is_a: GO:0005773 ! vacuole

[Term]
id: GO:0000326
name: protein storage vacuole
namespace: cellular_component
def: "A storage vacuole that contains a lytic vacuole; identified in plants." [PMID:11739409]
is_a: GO:0000322 ! storage vacuole
is_a: GO:0000325 ! plant-type vacuole

[Term]
id: GO:0000327
name: lytic vacuole within protein storage vacuole
namespace: cellular_component
def: "A membrane-bounded compartment containing crystals of phytic acid and proteins characteristic of a lytic vacuole, found within a storage vacuole." [PMID:11739490]
is_a: GO:0000323 ! lytic vacuole
is_a: GO:0044437 ! vacuolar part
intersection_of: GO:0000323 ! lytic vacuole
intersection_of: part_of GO:0000326 ! protein storage vacuole
relationship: part_of GO:0000326 ! protein storage vacuole

[Term]
id: GO:0000328
name: fungal-type vacuole lumen
namespace: cellular_component
def: "The volume enclosed within the vacuolar membrane of a vacuole, the shape of which correlates with cell cycle phase. An example of this structure is found in Saccharomyces cerevisiae." [GOC:krc, GOC:mtg_sensu]
synonym: "lumen of vacuole with cell cycle-correlated morphology" EXACT []
is_a: GO:0005775 ! vacuolar lumen
relationship: part_of GO:0000324 ! fungal-type vacuole

[Term]
id: GO:0000329
name: fungal-type vacuole membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae." [GOC:krc, GOC:mtg_sensu]
synonym: "fungal-type vacuolar membrane" RELATED []
synonym: "membrane of vacuole with cell cycle-correlated morphology" EXACT []
is_a: GO:0098852 ! lytic vacuole membrane
relationship: part_of GO:0000324 ! fungal-type vacuole

[Term]
id: GO:0000330
name: plant-type vacuole lumen
namespace: cellular_component
def: "The volume enclosed within the vacuolar membrane of a vacuole that retains the same shape regardless of cell cycle phase. An example of this is found in Arabidopsis thaliana." [GOC:krc, GOC:mtg_sensu]
synonym: "lumen of vacuole with cell cycle-independent morphology" EXACT []
is_a: GO:0005775 ! vacuolar lumen
relationship: part_of GO:0000325 ! plant-type vacuole

[Term]
id: GO:0000331
name: contractile vacuole
namespace: cellular_component
def: "A specialized vacuole of eukaryotic cells, especially Protozoa, that fills with water from the cytoplasm and then discharges this externally by the opening of contractile vacuole pores. Its function is probably osmoregulatory." [GOC:jl, PMID:10503189]
xref: Wikipedia:Contractile_vacuole
is_a: GO:0005773 ! vacuole
is_a: GO:0016023 ! cytoplasmic, membrane-bounded vesicle

[Term]
id: GO:0000332
name: template for synthesis of G-rich strand of telomere DNA activity
namespace: molecular_function
def: "Provision of the template used by reverse transcriptase to synthesize the G-rich strand of telomeric DNA." [PMID:11812242]
comment: Note that this term describes the activity of an RNA gene product that interacts with other nucleic acid molecules via base pairing; it should not be used to annotate proteins.
synonym: "telomerase RNA" EXACT []
synonym: "telomerase, template" EXACT []
is_a: GO:0000497 ! base pairing with DNA
relationship: part_of GO:0003720 ! telomerase activity

[Term]
id: GO:0000333
name: telomerase catalytic core complex
namespace: cellular_component
def: "The minimal catalytic core of telomerase is a ribonucleoprotein complex composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition." [GOC:BHF-UCL, PMID:11884619, PMID:1808260]
synonym: "TERT-TERC complex" RELATED [GOC:nc, PMID:19701182]
is_a: GO:0005697 ! telomerase holoenzyme complex

[Term]
id: GO:0000334
name: 3-hydroxyanthranilate 3,4-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxyanthranilate + O(2) = cis,cis-2-amino-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+)." [EC:1.13.11.6, RHEA:17956]
subset: gosubset_prok
synonym: "3-hydroxyanthranilate oxygenase activity" EXACT [EC:1.13.11.6]
synonym: "3-hydroxyanthranilate:oxygen 3,4-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.6]
synonym: "3-hydroxyanthranilic acid dioxygenase activity" EXACT [EC:1.13.11.6]
synonym: "3-hydroxyanthranilic acid oxygenase activity" EXACT [EC:1.13.11.6]
synonym: "3-hydroxyanthranilic oxygenase activity" EXACT [EC:1.13.11.6]
synonym: "3HAO" RELATED [EC:1.13.11.6]
xref: EC:1.13.11.6
xref: KEGG:R02665
xref: MetaCyc:1.13.11.6-RXN
xref: Reactome:REACT_106067 "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde, Danio rerio"
xref: Reactome:REACT_107237 "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde, Rattus norvegicus"
xref: Reactome:REACT_108663 "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde, Taeniopygia guttata"
xref: Reactome:REACT_108942 "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde, Canis familiaris"
xref: Reactome:REACT_612 "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde, Homo sapiens"
xref: Reactome:REACT_78765 "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde, Caenorhabditis elegans"
xref: Reactome:REACT_81621 "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde, Sus scrofa"
xref: Reactome:REACT_83535 "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde, Saccharomyces cerevisiae"
xref: Reactome:REACT_83862 "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde, Dictyostelium discoideum"
xref: Reactome:REACT_84121 "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde, Gallus gallus"
xref: Reactome:REACT_86308 "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde, Xenopus tropicalis"
xref: Reactome:REACT_93632 "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde, Bos taurus"
xref: Reactome:REACT_94190 "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde, Mus musculus"
xref: RHEA:17956
xref: UM-BBD_reactionID:r1027
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0000335
name: negative regulation of transposition, DNA-mediated
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA transposition." [GOC:dph, GOC:krc, GOC:tb]
subset: gosubset_prok
synonym: "down regulation of DNA transposition" EXACT []
synonym: "down-regulation of DNA transposition" EXACT []
synonym: "downregulation of DNA transposition" EXACT []
synonym: "inhibition of DNA transposition" NARROW []
synonym: "negative regulation of DNA transposition" EXACT [GOC:dph]
is_a: GO:0000337 ! regulation of transposition, DNA-mediated
is_a: GO:0010529 ! negative regulation of transposition
is_a: GO:0045910 ! negative regulation of DNA recombination
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006313 ! transposition, DNA-mediated
relationship: negatively_regulates GO:0006313 ! transposition, DNA-mediated

[Term]
id: GO:0000336
name: positive regulation of transposition, DNA-mediated
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA transposition." [GOC:dph, GOC:krc]
subset: gosubset_prok
synonym: "activation of DNA transposition" NARROW []
synonym: "positive regulation of DNA transposition" EXACT [GOC:dph]
synonym: "stimulation of DNA transposition" NARROW []
synonym: "up regulation of DNA transposition" EXACT []
synonym: "up-regulation of DNA transposition" EXACT []
synonym: "upregulation of DNA transposition" EXACT []
is_a: GO:0000337 ! regulation of transposition, DNA-mediated
is_a: GO:0010530 ! positive regulation of transposition
is_a: GO:0045911 ! positive regulation of DNA recombination
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006313 ! transposition, DNA-mediated
relationship: positively_regulates GO:0006313 ! transposition, DNA-mediated

[Term]
id: GO:0000337
name: regulation of transposition, DNA-mediated
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA transposition, the process of transposing (moving to a different location) a segment of a chromosome or a piece of a DNA molecule." [GOC:dph, GOC:krc]
subset: gosubset_prok
synonym: "regulation of DNA transposition" EXACT [GOC:dph]
is_a: GO:0000018 ! regulation of DNA recombination
is_a: GO:0010528 ! regulation of transposition
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006313 ! transposition, DNA-mediated
relationship: regulates GO:0006313 ! transposition, DNA-mediated

[Term]
id: GO:0000338
name: protein deneddylation
namespace: biological_process
def: "The removal of a ubiquitin-like protein of the NEDD8 type from a protein." [GOC:krc]
is_a: GO:0070646 ! protein modification by small protein removal

[Term]
id: GO:0000339
name: RNA cap binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule." [GOC:krc]
synonym: "binding to mRNA cap" NARROW []
synonym: "mRNA cap binding" NARROW []
synonym: "snRNA cap binding" NARROW []
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0000340
name: RNA 7-methylguanosine cap binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II." [GOC:krc]
synonym: "RNA m7G cap binding" EXACT []
is_a: GO:0000339 ! RNA cap binding

[Term]
id: GO:0000341
name: RNA trimethylguanosine cap binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the trimethylguanosine (m(3)(2,2,7)-GTP) group located at the 5' end of some RNA molecules. Such trimethylated cap structures, generally produced by posttranscriptional modification of a 7-methylguanosine cap, are often found on snRNAs and snoRNAs transcribed by RNA polymerase II, but have also be found on snRNAs transcribed by RNA polymerase III. They have also been found on a subset of the mRNA population in some species, e.g. C. elegans." [GOC:krc]
synonym: "RNA m2,2,7G cap binding" EXACT []
is_a: GO:0000339 ! RNA cap binding

[Term]
id: GO:0000342
name: RNA cap 4 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a hypermethylated cap structure consisting of 7-methylguanosine (m(7)G) followed by four methylated nucleotides (cap 4): 7-methylguanosine-ppp-N6, N6, 2'-O-trimethyladenosine-p-2'-O-methyladenosine-p-2'-O-methylcytosine-p-N3, 2'-O-dimethyluridine Such caps are known to be found at the 5' ends of SL RNAs of trypanosomatid protozoa." [GOC:krc, PMID:10880518, PMID:12121975]
is_a: GO:0000339 ! RNA cap binding

[Term]
id: GO:0000343
name: plastid-encoded plastid RNA polymerase complex A
namespace: cellular_component
def: "A plastid-encoded DNA-directed RNA polymerase complex that resembles eubacterial multisubunit RNA polymerases, with a core composed of alpha, beta, and beta-prime subunits. An additional subunit, a sigma factor, is required for promoter recognition. PEP-A is generated from the PEP-B form during chloroplast maturation to generate a complex composed of at least thirteen polypeptides that is not sensitive to the antibiotic rifampicin, like its precursor form the PEP-B complex." [PMID:10946105]
synonym: "PEP-A" EXACT []
is_a: GO:0000427 ! plastid-encoded plastid RNA polymerase complex

[Term]
id: GO:0000344
name: plastid-encoded plastid RNA polymerase complex B
namespace: cellular_component
def: "A plastid-encoded DNA-directed RNA polymerase complex that resembles eubacterial multisubunit RNA polymerases with a core composed of alpha, beta, and beta-prime subunits. An additional subunit, a sigma factor, is required for promoter recognition. PEP-B is distinguished from PEP-A by its sensitivity to the antibiotic rifampicin. PEP-B is found in both etioplasts and chloroplasts, but is the predominate form in etioplasts. It forms the core of the PEP-A form; the conversion from PEP-B to PEP-A occurs during chloroplast maturation." [PMID:10946105]
synonym: "PEP-B" EXACT []
is_a: GO:0000427 ! plastid-encoded plastid RNA polymerase complex

[Term]
id: GO:0000345
name: cytosolic DNA-directed RNA polymerase complex
namespace: cellular_component
def: "The eubacterial DNA-directed RNA polymerase is a multisubunit complex with a core composed of the essential subunits beta-prime, beta, and two copies of alpha and a fifth nonessential subunit called omega. An additional subunit, a sigma factor, is required for promoter recognition and specificity." [PMID:11158566]
subset: gosubset_prok
is_a: GO:0000428 ! DNA-directed RNA polymerase complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0000346
name: transcription export complex
namespace: cellular_component
def: "The transcription export (TREX) complex couples transcription elongation by RNA polymerase II to mRNA export. The complex associates with the polymerase and travels with it along the length of the transcribed gene. TREX is composed of the THO transcription elongation complex as well as other proteins that couple THO to mRNA export proteins. The TREX complex is known to be found in a wide range of eukaryotes, including S. cerevisiae and metazoans." [GOC:krc, PMID:11979277]
subset: goslim_pir
synonym: "TREX complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0000347
name: THO complex
namespace: cellular_component
def: "The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1p, Tho2p, Thp1p, and Mft1p, while the human complex is composed of 7 subunits." [GOC:krc, PMID:11060033, PMID:11979277, PMID:16983072]
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0000348
name: mRNA branch site recognition
namespace: biological_process
alt_id: GO:0000370
alt_id: GO:0000371
def: "Recognition of the pre-mRNA branch site sequence by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897]
comment: Note that this step represents the formation of the B complex (yeast) or the A complex (mammalian).
synonym: "nuclear mRNA branch site recognition" EXACT [GOC:vw]
synonym: "spliceosomal A complex biosynthesis" NARROW []
synonym: "spliceosomal A complex formation" NARROW []
synonym: "spliceosomal B complex biosynthesis" NARROW []
synonym: "spliceosomal B complex formation" NARROW []
synonym: "U12-type nuclear mRNA branch site recognition" NARROW []
synonym: "U2-type nuclear mRNA branch site recognition" NARROW []
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0000245 ! spliceosomal complex assembly

[Term]
id: GO:0000349
name: generation of catalytic spliceosome for first transesterification step
namespace: biological_process
alt_id: GO:0000356
alt_id: GO:0000357
def: "Formation of a catalytic spliceosome complex ready to perform the first splicing reaction. This occurs by an ATP-dependent conformational change of the pre-catalytic spliceosome." [GOC:krc, ISBN:0879695897]
comment: Note that this step represents the formation of the A2-2 complex (yeast) or the C1 complex (mammalian).
synonym: "catalytic spliceosome assembly for first transesterification step" RELATED []
synonym: "formation of catalytic spliceosome for first transesterification step" EXACT []
synonym: "spliceosomal A2-2 complex biosynthesis" NARROW []
synonym: "spliceosomal A2-2 complex formation" NARROW []
synonym: "spliceosomal C1 complex biosynthesis" NARROW []
synonym: "spliceosomal C1 complex formation" NARROW []
synonym: "U12-type catalytic spliceosome formation for first transesterification step" NARROW []
synonym: "U2-type catalytic spliceosome formation for first transesterification step" NARROW []
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0000393 ! spliceosomal conformational changes to generate catalytic conformation

[Term]
id: GO:0000350
name: generation of catalytic spliceosome for second transesterification step
namespace: biological_process
alt_id: GO:0000358
alt_id: GO:0000359
def: "Conformational rearrangement of the spliceosomal complex containing the RNA products from the 1st step of splicing to form the catalytic site for the second step of splicing." [GOC:krc, ISBN:0879695897]
comment: Note that this step represents formation of the A2-3 complex (yeast) or the C2 complex (mammalian).
synonym: "catalytic spliceosome assembly for second transesterification step" RELATED []
synonym: "formation of catalytic spliceosome for second transesterification step" EXACT []
synonym: "formation of catalytic U12-type spliceosome for second transesterification step" NARROW []
synonym: "formation of catalytic U2-type spliceosome for second transesterification step" NARROW []
synonym: "formation of spliceosomal A2-2 complex" NARROW []
synonym: "formation of spliceosomal C1 complex" NARROW []
synonym: "lariat formation, 5'-splice site cleavage" RELATED []
synonym: "spliceosomal A2-3 complex biosynthesis" NARROW []
synonym: "spliceosomal A2-3 complex formation" NARROW []
synonym: "spliceosomal C2 complex biosynthesis" NARROW []
synonym: "spliceosomal C2 complex formation" NARROW []
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0000393 ! spliceosomal conformational changes to generate catalytic conformation

[Term]
id: GO:0000352
name: trans assembly of SL-containing precatalytic spliceosome
namespace: biological_process
def: "Assembly of a spliceosomal complex containing the SL RNA and the pre-mRNA to be joined, as well as all the spliceosomal snRNPs involved in trans leader splicing. Formation of the trans leader spliceosome brings together the quadruple SL/U4/U5/U6 snRNP and the complex of the U2 snRNP with the splice site of the pre-mRNA." [GOC:krc, GOC:mtg_mpo, ISBN:0879695897]
synonym: "trans assembly of spliced leader-containing precatalytic spliceosome" EXACT []
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0000245 ! spliceosomal complex assembly
relationship: part_of GO:0045291 ! mRNA trans splicing, SL addition

[Term]
id: GO:0000353
name: formation of quadruple SL/U4/U5/U6 snRNP
namespace: biological_process
def: "Formation of a quadruple snRNP complex composed of the spliced leader (SL) RNA along with the U4/U6-U5 tri-snRNP complex. Interactions that may facilitate this include a duplex between the SL and U6 RNAs and interactions between the U5 RNA and the exon sequence at the 5' splice site within the SL RNA." [GOC:krc, ISBN:0879695897]
comment: Note that this step is analogous to 5' splice site selection in cis-splicing.
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0045291 ! mRNA trans splicing, SL addition

[Term]
id: GO:0000354
name: cis assembly of pre-catalytic spliceosome
namespace: biological_process
alt_id: GO:0000360
alt_id: GO:0000361
def: "Assembly of a spliceosomal complex containing the intact pre-mRNA and all of the spliceosomal snRNPs. This occurs when the tri-snRNP associates with the pre-mRNA and associated snRNPs in an ATP-dependent manner." [GOC:krc, GOC:mtg_mpo, ISBN:0879695897]
comment: Note that this step represents formation of the A2-1 complex (yeast) or the B1 complex (mammals).
synonym: "cis assembly of U12-type pre-catalytic spliceosome" NARROW []
synonym: "cis assembly of U2-type pre-catalytic spliceosome" NARROW []
synonym: "formation of spliceosomal A2-1 complex" NARROW []
synonym: "formation of spliceosomal B1 complex" NARROW []
synonym: "spliceosomal A2-1 complex biosynthesis" NARROW []
synonym: "spliceosomal A2-1 complex formation" NARROW []
synonym: "spliceosomal B1 complex biosynthesis" NARROW []
synonym: "spliceosomal B1 complex formation" NARROW []
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0000245 ! spliceosomal complex assembly
relationship: part_of GO:0045292 ! mRNA cis splicing, via spliceosome

[Term]
id: GO:0000362
name: obsolete first U2-type spliceosomal transesterification activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the first transesterification reaction of U2-type spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, which is still joined to the 3' exon. The catalytic site is thought to be formed by U6 and/or U2 snRNA, and/or associated proteins." [GOC:krc, ISBN:0879695897]
comment: This term was made obsolete because the activities used in the U2- and U12-type complexes are the same. The cellular component ontology should (and does) represent the two different complexes, but the molecular function ontology should not.
synonym: "first U2-type spliceosomal transesterification activity" EXACT []
synonym: "lariat formation, 5'-splice site cleavage" BROAD []
is_obsolete: true
replaced_by: GO:0000384

[Term]
id: GO:0000363
name: obsolete first U12-type spliceosomal transesterification activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the first transesterification reaction of U12-type spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, which is still joined to the 3' exon. The catalytic site is thought to be formed by U6atac snRNA and/or U2atac snRNA, and/or associated proteins." [GOC:krc, ISBN:0879695897]
comment: This term was made obsolete because the activities used in the U2- and U12-type complexes are the same. The cellular component ontology should (and does) represent the two different complexes, but the molecular function ontology should not.
synonym: "first U12-type spliceosomal transesterification activity" EXACT []
synonym: "lariat formation, 5'-splice site cleavage" BROAD []
is_obsolete: true
replaced_by: GO:0000384

[Term]
id: GO:0000364
name: obsolete second U2-type spliceosomal transesterification activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the second transesterification reaction of U2-type spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure. The catalytic site is thought to be formed by U6 and/or U2 snRNAs and/or associated proteins." [GOC:krc, ISBN:0879695897]
comment: This term was made obsolete because the activities used in the U2- and U12-type complexes are the same. The cellular component ontology should (and does) represent the two different complexes, but the molecular function ontology should not.
synonym: "3'-splice site cleavage, exon ligation" BROAD []
synonym: "second U2-type spliceosomal transesterification activity" EXACT []
is_obsolete: true
replaced_by: GO:0000386

[Term]
id: GO:0000365
name: mRNA trans splicing, via spliceosome
namespace: biological_process
def: "The joining together of exons from two different primary transcripts of messenger RNA (mRNA) via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0879695897]
synonym: "nuclear mRNA trans splicing, via spliceosome" EXACT [GOC:vw]
synonym: "nuclear mRNA trans splicing, via U2-type spliceosome" NARROW []
is_a: GO:0000398 ! mRNA splicing, via spliceosome

[Term]
id: GO:0000366
name: intergenic mRNA trans splicing
namespace: biological_process
def: "The joining together of two independently transcribed RNAs from two different genes, each of which also produces mRNA(s) via cis-splicing." [GOC:krc, PMID:11726664, PMID:12110900]
synonym: "intergenic nuclear mRNA trans splicing" EXACT [GOC:vw]
is_a: GO:0000365 ! mRNA trans splicing, via spliceosome
is_a: GO:0000380 ! alternative mRNA splicing, via spliceosome

[Term]
id: GO:0000367
name: obsolete second U12-type spliceosomal transesterification activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the second transesterification reaction of U12-type spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure. The catalytic site is thought to be formed by U6 and/or U2 snRNAs and/or associated proteins." [GOC:krc, ISBN:0879695897]
comment: This term was made obsolete because the activities used in the U2- and U12-type complexes are the same. The cellular component ontology should (and does) represent the two different complexes, but the molecular function ontology should not.
synonym: "3'-splice site cleavage, exon ligation" BROAD []
synonym: "second U12-type spliceosomal transesterification activity" EXACT []
is_obsolete: true
replaced_by: GO:0000386

[Term]
id: GO:0000372
name: Group I intron splicing
namespace: biological_process
def: "The splicing of Group I introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group I introns and involved in determining the locations of the splice sites (there do not appear to be consensus splice site sequences) as well as having a role in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions, generally with exogenous guanosine as the initiating nucleophile. The intron is excised as a linear piece (though it may subsequently circularize)." [GOC:krc, PMID:11377794]
comment: Note that Group I introns are known to be found in a number of places: rRNA, mRNA, and tRNA in organelles of fungi, plants, and protists; tRNA and mRNA of bacteria and bacteriophage; rRNA of protists and fungi; and occasionally in mRNA of animal mitochondria (e.g. sea anemone).
subset: gosubset_prok
synonym: "mRNA splicing" RELATED []
is_a: GO:0000376 ! RNA splicing, via transesterification reactions with guanosine as nucleophile

[Term]
id: GO:0000373
name: Group II intron splicing
namespace: biological_process
def: "The splicing of Group II introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group II introns and containing splice site consensus sequences, that is involved in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions (mechanistically similar to those for splicing of nuclear mRNAs) initiated by a bulged adenosine residue within the intron sequence as the initiating nucleophile. The intron is excised as a lariat." [GOC:krc, PMID:11377794]
comment: Note that Group II introns are known to be found in a number of places: rRNA, mRNA, and tRNA in organelles of fungi, plants, and protists; and mRNA of bacteria.
subset: gosubset_prok
synonym: "mRNA splicing" RELATED []
is_a: GO:0000377 ! RNA splicing, via transesterification reactions with bulged adenosine as nucleophile

[Term]
id: GO:0000374
name: Group III intron splicing
namespace: biological_process
def: "The splicing of Group III introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group III introns, that is involved in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions begun by a bulged adenosine residue within the intron sequence as the initiating nucleophile. The intron is excised as a lariat. Though very similar in structure and mechanism to Group II introns, Group III introns are smaller and more streamlined and the splice site consensus sequences are not as well conserved." [GOC:krc, PMID:11377794]
comment: Note that Group III introns are known to be found in mRNA of plastids of euglenoid protists.
subset: gosubset_prok
synonym: "mRNA splicing" RELATED []
is_a: GO:0000377 ! RNA splicing, via transesterification reactions with bulged adenosine as nucleophile

[Term]
id: GO:0000375
name: RNA splicing, via transesterification reactions
namespace: biological_process
alt_id: GO:0000385
alt_id: GO:0031202
def: "Splicing of RNA via a series of two transesterification reactions." [GOC:krc]
comment: Note that nuclear mRNA, Group I, Group II, and Group III introns are all spliced by a series of two transesterification reactions that occur within the RNA itself, or between two RNAs in trans splicing. Some of these require one or more proteins to stabilize the catalytic conformation, while others are autocatalytic. Note that tRNA introns are spliced by a different catalytic mechanism.
subset: gosubset_prok
synonym: "pre-mRNA splicing factor activity" RELATED [GOC:krc, GOC:mah]
synonym: "RNA splicing factor activity, transesterification mechanism" RELATED [GOC:krc, GOC:mah]
synonym: "spliceosomal catalysis" RELATED []
is_a: GO:0008380 ! RNA splicing

[Term]
id: GO:0000376
name: RNA splicing, via transesterification reactions with guanosine as nucleophile
namespace: biological_process
def: "Splicing of RNA via a series of two transesterification reactions with exogenous guanosine as the initiating nucleophile." [GOC:krc, PMID:11377794]
subset: gosubset_prok
is_a: GO:0000375 ! RNA splicing, via transesterification reactions

[Term]
id: GO:0000377
name: RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
namespace: biological_process
def: "Splicing of RNA via a series of two transesterification reactions with a bulged adenosine residue from the intron branch point as the initiating nucleophile. When the initial RNA for the splicing reaction is a single molecule (cis splicing), the excised intron is released in a lariat structure." [GOC:krc, PMID:11377794]
subset: gosubset_prok
synonym: "lariat RNA biosynthesis" RELATED []
synonym: "lariat RNA formation" RELATED []
is_a: GO:0000375 ! RNA splicing, via transesterification reactions

[Term]
id: GO:0000378
name: RNA exon ligation
namespace: biological_process
def: "The RNA metabolic process that joins two exons, each of which has free ends that were generated by endonucleolytic cleavages, by a ligation reaction." [GOC:krc, ISBN:0879695897]
comment: Note that this is not a part of spliceosomal RNA splicing.
subset: gosubset_prok
is_a: GO:0016070 ! RNA metabolic process
relationship: part_of GO:0000394 ! RNA splicing, via endonucleolytic cleavage and ligation

[Term]
id: GO:0000379
name: tRNA-type intron splice site recognition and cleavage
namespace: biological_process
def: "RNA processing that begins when the tertiary structure of a tRNA type intron is recognized, and ends when the endonucleolytic cleavage of the RNA at both the 5' and 3' splice sites occurs." [GOC:krc, GOC:mah, ISBN:0879695897]
subset: gosubset_prok
is_a: GO:0006396 ! RNA processing
relationship: part_of GO:0006388 ! tRNA splicing, via endonucleolytic cleavage and ligation

[Term]
id: GO:0000380
name: alternative mRNA splicing, via spliceosome
namespace: biological_process
def: "The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition." [GOC:krc, PMID:12110900]
comment: Note that this process most commonly occurs in cis, selecting or skipping exons from the same primary transcript, but it has also been observed to occur in trans at low frequency, at least in some mammals.
synonym: "alternative nuclear mRNA splicing, via spliceosome" EXACT [GOC:vw]
synonym: "splice site selection" BROAD []
is_a: GO:0000398 ! mRNA splicing, via spliceosome

[Term]
id: GO:0000381
name: regulation of alternative mRNA splicing, via spliceosome
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc]
synonym: "regulation of alternative nuclear mRNA splicing, via spliceosome" EXACT [GOC:vw]
synonym: "splice site selection" BROAD []
is_a: GO:0048024 ! regulation of mRNA splicing, via spliceosome
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000380 ! alternative mRNA splicing, via spliceosome
relationship: regulates GO:0000380 ! alternative mRNA splicing, via spliceosome

[Term]
id: GO:0000384
name: first spliceosomal transesterification activity
namespace: molecular_function
def: "Catalysis of the first transesterification reaction of spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, while it is still joined to the 3' exon." [GOC:krc, ISBN:0879695897]
synonym: "lariat formation, 5'-splice site cleavage" RELATED []
is_a: GO:0003824 ! catalytic activity
relationship: part_of GO:0000375 ! RNA splicing, via transesterification reactions

[Term]
id: GO:0000386
name: second spliceosomal transesterification activity
namespace: molecular_function
def: "Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure." [GOC:krc, ISBN:0879695897]
synonym: "3'-splice site cleavage, exon ligation" BROAD []
synonym: "lariat formation, 5'-splice site cleavage" RELATED []
is_a: GO:0003824 ! catalytic activity
relationship: part_of GO:0000375 ! RNA splicing, via transesterification reactions

[Term]
id: GO:0000387
name: spliceosomal snRNP assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome." [GOC:krc, GOC:mah, ISBN:0879695897]
synonym: "spliceosomal snRNP biogenesis" RELATED [GOC:mah]
xref: Reactome:REACT_10002 "snRNA Cap hypermethylation, Homo sapiens"
xref: Reactome:REACT_10041 "Loading and methylation of Sm proteins onto SMN Complexes, Homo sapiens"
xref: Reactome:REACT_100869 "snRNP:Snurportin complex formation, Canis familiaris"
xref: Reactome:REACT_100915 "snRNP:Snurportin complex formation, Rattus norvegicus"
xref: Reactome:REACT_101141 "snRNP Assembly, Mus musculus"
xref: Reactome:REACT_102135 "snRNA Cap hypermethylation, Danio rerio"
xref: Reactome:REACT_102362 "snRNP complex assembly, Danio rerio"
xref: Reactome:REACT_107811 "snRNP Assembly, Gallus gallus"
xref: Reactome:REACT_108169 "snRNA Cap hypermethylation, Rattus norvegicus"
xref: Reactome:REACT_108689 "snRNP Assembly, Rattus norvegicus"
xref: Reactome:REACT_109502 "Loading and methylation of Sm proteins onto SMN Complexes, Danio rerio"
xref: Reactome:REACT_11066 "snRNP Assembly, Homo sapiens"
xref: Reactome:REACT_112455 "Loading and methylation of Sm proteins onto SMN Complexes, Xenopus tropicalis"
xref: Reactome:REACT_29060 "snRNP:Snurportin complex formation, Drosophila melanogaster"
xref: Reactome:REACT_29381 "snRNA Cap hypermethylation, Gallus gallus"
xref: Reactome:REACT_29703 "snRNP Assembly, Taeniopygia guttata"
xref: Reactome:REACT_29866 "snRNP:Snurportin complex formation, Mus musculus"
xref: Reactome:REACT_30125 "snRNP complex assembly, Bos taurus"
xref: Reactome:REACT_30397 "snRNP Assembly, Sus scrofa"
xref: Reactome:REACT_30799 "snRNP:Snurportin complex formation, Danio rerio"
xref: Reactome:REACT_30895 "snRNP complex assembly, Canis familiaris"
xref: Reactome:REACT_31007 "snRNP complex assembly, Mus musculus"
xref: Reactome:REACT_31363 "snRNP complex assembly, Gallus gallus"
xref: Reactome:REACT_31615 "snRNP Assembly, Drosophila melanogaster"
xref: Reactome:REACT_32359 "snRNP complex assembly, Rattus norvegicus"
xref: Reactome:REACT_54083 "snRNA Cap hypermethylation, Bos taurus"
xref: Reactome:REACT_77054 "snRNP Assembly, Canis familiaris"
xref: Reactome:REACT_79845 "snRNA Cap hypermethylation, Xenopus tropicalis"
xref: Reactome:REACT_81235 "Loading and methylation of Sm proteins onto SMN Complexes, Mus musculus"
xref: Reactome:REACT_81911 "snRNP complex assembly, Xenopus tropicalis"
xref: Reactome:REACT_82745 "snRNA Cap hypermethylation, Drosophila melanogaster"
xref: Reactome:REACT_85882 "snRNP Assembly, Danio rerio"
xref: Reactome:REACT_86133 "snRNP complex assembly, Drosophila melanogaster"
xref: Reactome:REACT_88437 "snRNP Assembly, Xenopus tropicalis"
xref: Reactome:REACT_88858 "snRNA Cap hypermethylation, Canis familiaris"
xref: Reactome:REACT_93259 "snRNP:Snurportin complex formation, Xenopus tropicalis"
xref: Reactome:REACT_93444 "snRNP Assembly, Bos taurus"
xref: Reactome:REACT_93869 "snRNP:Snurportin complex formation, Gallus gallus"
xref: Reactome:REACT_95210 "snRNA Cap hypermethylation, Mus musculus"
xref: Reactome:REACT_99021 "snRNP:Snurportin complex formation, Bos taurus"
xref: Reactome:REACT_9946 "snRNP:Snurportin complex formation, Homo sapiens"
xref: Reactome:REACT_9957 "snRNP complex assembly, Homo sapiens"
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0000398 ! mRNA splicing, via spliceosome

[Term]
id: GO:0000388
name: spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
namespace: biological_process
alt_id: GO:0000396
alt_id: GO:0000397
def: "Rearrangement of the pre-catalytic spliceosome containing U4 (or U4atac) and U1 (or U11) snRNPs to unpair U4 (or U4atac) from U6 (or U6atac) and release it from the spliceosomal complex along with U1 (or U11)." [GOC:krc, ISBN:0879695897]
comment: Note that this step represents formation of the A1 complex (yeast) or the B2 complex (mammalian).
synonym: "3'-splice site cleavage, exon ligation" BROAD []
synonym: "spliceosomal A1 complex biosynthesis" NARROW []
synonym: "spliceosomal A1 complex formation" NARROW []
synonym: "spliceosomal B2 complex biosynthesis" NARROW []
synonym: "spliceosomal B2 complex formation" NARROW []
synonym: "U12-type spliceosome conformational change to release U4atac and U11" NARROW []
synonym: "U2-type spliceosome conformational change to release U4 and U1" NARROW []
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0000393 ! spliceosomal conformational changes to generate catalytic conformation

[Term]
id: GO:0000389
name: mRNA 3'-splice site recognition
namespace: biological_process
alt_id: GO:0000382
alt_id: GO:0000383
def: "Recognition of the intron 3'-splice site by components of the assembling U2- or U12-type spliceosome." [GOC:krc, ISBN:0879695897]
synonym: "nuclear mRNA 3'-splice site recognition" EXACT [GOC:vw]
synonym: "U12-type nuclear mRNA 3'-splice site recognition" NARROW []
synonym: "U2-type nuclear mRNA 3'-splice site recognition" NARROW []
is_a: GO:0006376 ! mRNA splice site selection

[Term]
id: GO:0000390
name: spliceosomal complex disassembly
namespace: biological_process
alt_id: GO:0000391
alt_id: GO:0000392
def: "Disassembly of a spliceosomal complex with the ATP-dependent release of the product RNAs, one of which is composed of the joined exons. In cis splicing, the other product is the excised sequence, often a single intron, in a lariat structure." [GOC:krc, ISBN:0879695897]
synonym: "spliceosome complex disassembly" EXACT []
synonym: "spliceosome disassembly" BROAD []
synonym: "U12-type spliceosome disassembly" NARROW []
synonym: "U2-type spliceosome disassembly" NARROW []
is_a: GO:0032988 ! ribonucleoprotein complex disassembly
relationship: part_of GO:0000398 ! mRNA splicing, via spliceosome

[Term]
id: GO:0000393
name: spliceosomal conformational changes to generate catalytic conformation
namespace: biological_process
def: "Structural rearrangements of the spliceosome complex, containing RNA to be spliced, to generate a catalytic conformation." [GOC:krc]
synonym: "3'-splice site cleavage, exon ligation" BROAD []
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0000398 ! mRNA splicing, via spliceosome

[Term]
id: GO:0000394
name: RNA splicing, via endonucleolytic cleavage and ligation
namespace: biological_process
def: "Splicing of RNA via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons." [GOC:krc, ISBN:0879695897]
comment: Note that while typically associated with tRNA splicing, this mechanism of splicing is known to be used for some non-tRNA substrates, e.g. HAC1 (YFL031W) in S. cerevisiae and an intron in the 23S rRNA of the Archaeal species Desulfurococcus mobilis.
subset: gosubset_prok
synonym: "mRNA splicing" BROAD []
is_a: GO:0008380 ! RNA splicing

[Term]
id: GO:0000395
name: mRNA 5'-splice site recognition
namespace: biological_process
alt_id: GO:0000368
alt_id: GO:0000369
def: "Recognition of the intron 5'-splice site by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897]
comment: Note that this step represents formation of the Commitment Complex (CC, in yeast) or the E complex (mammalian).
synonym: "nuclear mRNA 5' splice site recognition" EXACT []
synonym: "nuclear mRNA 5'-splice site recognition" EXACT [GOC:vw]
synonym: "spliceosomal CC complex biosynthesis" NARROW []
synonym: "spliceosomal CC complex formation" NARROW []
synonym: "spliceosomal commitment complex biosynthesis" NARROW []
synonym: "spliceosomal commitment complex formation" NARROW []
synonym: "spliceosomal E complex biosynthesis" NARROW []
synonym: "spliceosomal E complex formation" NARROW []
synonym: "U12-type nuclear mRNA 5' splice site recognition" NARROW []
synonym: "U12-type nuclear mRNA 5'-splice site recognition" NARROW []
synonym: "U2-type nuclear mRNA 5' splice site recognition" NARROW []
synonym: "U2-type nuclear mRNA 5'-splice site recognition" NARROW []
is_a: GO:0006376 ! mRNA splice site selection
relationship: part_of GO:0045292 ! mRNA cis splicing, via spliceosome

[Term]
id: GO:0000398
name: mRNA splicing, via spliceosome
namespace: biological_process
alt_id: GO:0006374
alt_id: GO:0006375
def: "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
comment: Note that although the many U12-type introns have the sequence AT-AC at the intron termini, some introns with these terminal sequences are spliced by the U2-type spliceosome. The distinguishing characteristics are sequences near the 5' splice site and the branch point sequences of the intron. Note that although the majority of U2-type introns have the sequence GU-AG at the intron termini, some introns with these terminal sequences are spliced by the U12-type spliceosome. The distinguishing characteristics are sequences near the 5' splice site and the branch point sequences of the intron.
synonym: "mRNA splicing" BROAD []
synonym: "nuclear mRNA splicing via U12-type spliceosome" NARROW []
synonym: "nuclear mRNA splicing via U2-type spliceosome" NARROW []
synonym: "nuclear mRNA splicing, via spliceosome" EXACT [GOC:krc, GOC:vw]
synonym: "pre-mRNA splicing" BROAD []
synonym: "splicing AT-AC intron" RELATED []
synonym: "splicing GT-AG intron" RELATED []
xref: Reactome:REACT_101135 "mRNA Splicing - Minor Pathway, Drosophila melanogaster"
xref: Reactome:REACT_101749 "mRNA Splicing - Minor Pathway, Caenorhabditis elegans"
xref: Reactome:REACT_106268 "mRNA Splicing - Major Pathway, Gallus gallus"
xref: Reactome:REACT_107907 "mRNA Splicing - Minor Pathway, Schizosaccharomyces pombe"
xref: Reactome:REACT_109091 "mRNA Splicing - Minor Pathway, Rattus norvegicus"
xref: Reactome:REACT_112200 "mRNA Splicing - Major Pathway, Arabidopsis thaliana"
xref: Reactome:REACT_114266 "mRNA Splicing - Major Pathway, Oryza sativa"
xref: Reactome:REACT_114738 "mRNA Splicing - Major Pathway, Taeniopygia guttata"
xref: Reactome:REACT_1753 "mRNA Splicing - Minor Pathway, Homo sapiens"
xref: Reactome:REACT_30984 "mRNA Splicing - Minor Pathway, Plasmodium falciparum"
xref: Reactome:REACT_32449 "mRNA Splicing - Minor Pathway, Canis familiaris"
xref: Reactome:REACT_34020 "mRNA Splicing - Minor Pathway, Dictyostelium discoideum"
xref: Reactome:REACT_467 "mRNA Splicing - Major Pathway, Homo sapiens"
xref: Reactome:REACT_81417 "mRNA Splicing - Major Pathway, Canis familiaris"
xref: Reactome:REACT_82149 "mRNA Splicing - Minor Pathway, Danio rerio"
xref: Reactome:REACT_85452 "mRNA Splicing - Major Pathway, Bos taurus"
xref: Reactome:REACT_86489 "mRNA Splicing - Minor Pathway, Mus musculus"
xref: Reactome:REACT_88186 "mRNA Splicing - Minor Pathway, Oryza sativa"
xref: Reactome:REACT_89168 "mRNA Splicing - Minor Pathway, Gallus gallus"
xref: Reactome:REACT_90296 "mRNA Splicing - Major Pathway, Danio rerio"
xref: Reactome:REACT_91088 "mRNA Splicing - Minor Pathway, Arabidopsis thaliana"
xref: Reactome:REACT_91611 "mRNA Splicing - Major Pathway, Drosophila melanogaster"
xref: Reactome:REACT_91773 "mRNA Splicing - Minor Pathway, Bos taurus"
xref: Reactome:REACT_93740 "mRNA Splicing - Major Pathway, Caenorhabditis elegans"
xref: Reactome:REACT_93843 "mRNA Splicing - Major Pathway, Rattus norvegicus"
xref: Reactome:REACT_95764 "mRNA Splicing - Major Pathway, Mus musculus"
xref: Reactome:REACT_99123 "mRNA Splicing - Major Pathway, Xenopus tropicalis"
xref: Reactome:REACT_99763 "mRNA Splicing - Minor Pathway, Xenopus tropicalis"
is_a: GO:0000377 ! RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
is_a: GO:0006397 ! mRNA processing

[Term]
id: GO:0000399
name: cellular bud neck septin structure
namespace: cellular_component
def: "Any of a series of septin structures that are localized in the bud neck of a budding fungal cell during the cell cycle." [GOC:krc]
is_a: GO:0032155 ! cell division site part
relationship: part_of GO:0005935 ! cellular bud neck

[Term]
id: GO:0000400
name: four-way junction DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with DNA containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices." [GOC:krc, ISBN:0815332181, PMID:15563464]
synonym: "forked DNA binding" BROAD []
synonym: "Holliday junction binding" EXACT []
is_a: GO:0000217 ! DNA secondary structure binding

[Term]
id: GO:0000401
name: open form four-way junction DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with DNA containing the open form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The open form of a four-way junction can be diagrammed without any of the strands crossing over." [GOC:krc, ISBN:0815332181, PMID:15563464]
synonym: "open form Holliday junction binding" EXACT []
is_a: GO:0000400 ! four-way junction DNA binding

[Term]
id: GO:0000402
name: crossed form four-way junction DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with DNA containing the crossed form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The crossed form of a four-way junction cannot be diagrammed without any of the strands crossing over, and instead contains a single crossover between two of the strands." [GOC:krc, ISBN:0815332181, PMID:15563464]
synonym: "crossed form Holliday junction binding" EXACT []
is_a: GO:0000400 ! four-way junction DNA binding

[Term]
id: GO:0000403
name: Y-form DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with segment of DNA shaped like a Y. This shape occurs when DNA contains a region of paired double-stranded DNA on one end and a region of unpaired DNA strands on the opposite end." [GOC:elh, PMID:16781730]
synonym: "forked DNA binding" BROAD []
synonym: "splayed Y-form DNA binding" EXACT []
is_a: GO:0000217 ! DNA secondary structure binding

[Term]
id: GO:0000404
name: heteroduplex DNA loop binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with DNA containing a loop. A loop occurs when DNA contains a large insertion or deletion that causes a region of unpaired single-stranded DNA to loop out, while the rest of the DNA is in a paired double-stranded configuration." [GOC:elh, PMID:16781730]
synonym: "loop DNA binding" RELATED [GOC:jh]
is_a: GO:0000217 ! DNA secondary structure binding
is_a: GO:0032135 ! DNA insertion or deletion binding

[Term]
id: GO:0000405
name: bubble DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with DNA that contains a bubble. A bubble occurs when DNA contains a region of unpaired, single-stranded DNA flanked on both sides by regions of paired, double-stranded DNA." [GOC:elh, GOC:vw, PMID:16781730]
is_a: GO:0000217 ! DNA secondary structure binding

[Term]
id: GO:0000406
name: double-strand/single-strand DNA junction binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a region of DNA that contains double-stranded DNA flanked by a region of single-stranded DNA." [GOC:elh, PMID:16781730]
is_a: GO:0000217 ! DNA secondary structure binding

[Term]
id: GO:0000407
name: pre-autophagosomal structure
namespace: cellular_component
def: "A punctate structure localized in the vicinity of the vacuole that is required for the formation of autophagosomes." [GOC:elh, PMID:11689437, PMID:12048214, PMID:12554655]
synonym: "isolation membrane" RELATED []
synonym: "PAS" EXACT []
synonym: "perivacuolar space" NARROW []
synonym: "phagophore" RELATED [GOC:bf]
synonym: "phagophore assembly site" RELATED []
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0000408
name: EKC/KEOPS complex
namespace: cellular_component
def: "A protein complex involved in t6A tRNA modification; originally proposed to be involved in transcription as well as promoting telomere uncapping and telomere elongation. For example, in Saccharomyces cerevisiae the complex contains Bud32p, Kae1p, Gon7p, Cgi121p, and Pcc1p." [GOC:elh, GOC:vw, PMID:16564010, PMID:16874308, PMID:21183954, PMID:23945934]
synonym: "Endopeptidase-like Kinase Chromatin-associated protein complex" EXACT []
synonym: "KEOPS/EKC complex" EXACT [PMID:21183954, PMID:23945934]
synonym: "Kinase, putative Endopeptidase and Other Proteins of Small size protein complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0000409
name: regulation of transcription by galactose
namespace: biological_process
def: "Any process involving galactose that modulates the frequency, rate or extent or transcription." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0006355 ! regulation of transcription, DNA-templated

[Term]
id: GO:0000410
name: negative regulation of transcription by galactose
namespace: biological_process
def: "Any process involving galactose that stops, prevents or reduces the rate of transcription." [GOC:mah]
synonym: "down regulation of transcription by galactose" EXACT []
synonym: "down-regulation of transcription by galactose" EXACT []
synonym: "downregulation of transcription by galactose" EXACT []
synonym: "inhibition of transcription by galactose" NARROW []
is_a: GO:0000409 ! regulation of transcription by galactose
is_a: GO:0045013 ! carbon catabolite repression of transcription

[Term]
id: GO:0000411
name: positive regulation of transcription by galactose
namespace: biological_process
def: "Any process involving galactose that activates or increases the rate of transcription." [GOC:go_curators]
synonym: "activation of transcription by galactose" NARROW []
synonym: "stimulation of transcription by galactose" NARROW []
synonym: "up regulation of transcription by galactose" EXACT []
synonym: "up-regulation of transcription by galactose" EXACT []
synonym: "upregulation of transcription by galactose" EXACT []
is_a: GO:0000409 ! regulation of transcription by galactose
is_a: GO:0045991 ! carbon catabolite activation of transcription

[Term]
id: GO:0000412
name: histone peptidyl-prolyl isomerization
namespace: biological_process
def: "The modification of a histone by cis-trans isomerization of a proline residue." [GOC:krc]
synonym: "histone proline isomerization" EXACT []
is_a: GO:0000413 ! protein peptidyl-prolyl isomerization
is_a: GO:0016570 ! histone modification

[Term]
id: GO:0000413
name: protein peptidyl-prolyl isomerization
namespace: biological_process
def: "The modification of a protein by cis-trans isomerization of a proline residue." [GOC:krc, PMID:16959570]
synonym: "protein proline isomerization" EXACT []
is_a: GO:0018208 ! peptidyl-proline modification

[Term]
id: GO:0000414
name: regulation of histone H3-K36 methylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3." [GOC:krc]
is_a: GO:0031060 ! regulation of histone methylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010452 ! histone H3-K36 methylation
relationship: regulates GO:0010452 ! histone H3-K36 methylation

[Term]
id: GO:0000415
name: negative regulation of histone H3-K36 methylation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3." [GOC:krc]
synonym: "down regulation of histone H3-K36 methylation" EXACT []
synonym: "down-regulation of histone H3-K36 methylation" EXACT []
synonym: "downregulation of histone H3-K36 methylation" EXACT []
synonym: "inhibition of histone H3-K36 methylation" NARROW []
is_a: GO:0000414 ! regulation of histone H3-K36 methylation
is_a: GO:0031061 ! negative regulation of histone methylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010452 ! histone H3-K36 methylation
relationship: negatively_regulates GO:0010452 ! histone H3-K36 methylation

[Term]
id: GO:0000416
name: positive regulation of histone H3-K36 methylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3." [GOC:krc]
synonym: "activation of histone H3-K36 methylation" NARROW []
synonym: "stimulation of histone H3-K36 methylation" NARROW []
synonym: "up regulation of histone H3-K36 methylation" EXACT []
synonym: "up-regulation of histone H3-K36 methylation" EXACT []
synonym: "upregulation of histone H3-K36 methylation" EXACT []
is_a: GO:0000414 ! regulation of histone H3-K36 methylation
is_a: GO:0031062 ! positive regulation of histone methylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010452 ! histone H3-K36 methylation
relationship: positively_regulates GO:0010452 ! histone H3-K36 methylation

[Term]
id: GO:0000417
name: HIR complex
namespace: cellular_component
def: "A protein complex proposed to be involved in replication-independent nucleosome assembly, by promoting histone deposition onto DNA. For example, in Saccharomyces, the complex contains Hir1p, Hir2p, Hir3p, and Hpc2p." [GOC:elh, GOC:mah, PMID:16303565, PMID:17180700]
synonym: "HIRA complex" EXACT [PMID:19620282, PMID:20976105]
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0000418
name: DNA-directed RNA polymerase IV complex
namespace: cellular_component
alt_id: GO:0000420
def: "RNA polymerase IV is a multisubunit RNA polymerase complex found in the nucleus of plants and involved in accumulation of siRNAs and in DNA methylation-dependent silencing of endogenous repeated sequences. Pol IV is composed of subunits that are paralogous or identical to the 12 subunits of Pol II. The largest and second-largest subunits of Pol IV are the catalytic subunits and share similarity with the corresponding subunits of other eukaryotic and bacterial multisubunit RNA polymerases. The second largest subunit is also found in RNA polymerase V, while the largest subunit is found only in RNAP IV complex." [GOC:krc, GOC:mtg_sensu, PMID:15692015, PMID:15766525, PMID:16140984, PMID:19110459]
synonym: "DNA-directed RNA polymerase IVa complex" EXACT []
is_a: GO:0044451 ! nucleoplasm part
is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex

[Term]
id: GO:0000419
name: DNA-directed RNA polymerase V complex
namespace: cellular_component
alt_id: GO:0080137
def: "RNA polymerase V is a multisubunit RNA polymerase complex found in the nucleus of plants and involved in accumulation of siRNAs and in DNA methylation-dependent silencing of endogenous repeated sequences. Pol V is composed of subunits that are paralogous or identical to the 12 subunits of Pol II. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The second largest subunit is also found in RNA polymerase IVa, while the largest subunit is found only in the IVa complex and contains an extended C-terminal domain (CTD) that includes multiple repeats of a 16 amino-acid consensus sequence as well as other sequences. The remainder of the complex is composed of smaller subunits." [GOC:krc, GOC:mtg_sensu, PMID:16140984, PMID:19110459]
synonym: "DNA-directed RNA polymerase IVb complex" EXACT []
is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex

[Term]
id: GO:0000421
name: autophagosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered." [GOC:autophagy, GOC:isa_complete]
synonym: "autophagic vacuole membrane" EXACT [GOC:autophagy]
is_a: GO:0005774 ! vacuolar membrane
relationship: part_of GO:0005776 ! autophagosome

[Term]
id: GO:0000422
name: mitophagy
namespace: biological_process
def: "The autophagic process in which mitochondria are delivered to the vacuole and degraded in response to changing cellular conditions." [GOC:autophagy, PMID:15798367, PMID:19289147, PMID:23065344]
synonym: "mitochondrion autophagy" EXACT [GOC:autophagy]
xref: Wikipedia:Autophagy_(cellular)#Selective_autophagy
xref: Wikipedia:Mitophagy
is_a: GO:0006914 ! autophagy
is_a: GO:0007005 ! mitochondrion organization
is_a: GO:0044712 ! single-organism catabolic process
is_a: GO:0061726 ! mitochondrion disassembly

[Term]
id: GO:0000423
name: macromitophagy
namespace: biological_process
def: "Degradation of a mitochondrion by macroautophagy." [PMID:15798367]
is_a: GO:0000422 ! mitophagy
is_a: GO:0016236 ! macroautophagy

[Term]
id: GO:0000424
name: microautophagy of mitochondrion
namespace: biological_process
def: "Degradation of a mitochondrion by lysosomal microautophagy." [PMID:15798367, PMID:27003723]
synonym: "micromitophagy" BROAD [PMID:27003723]
is_a: GO:0000422 ! mitophagy
is_a: GO:0016237 ! lysosomal microautophagy

[Term]
id: GO:0000425
name: macropexophagy
namespace: biological_process
def: "Degradation of a peroxisome by macroautophagy." [PMID:12914914, PMID:16973210]
is_a: GO:0016236 ! macroautophagy
is_a: GO:0030242 ! pexophagy

[Term]
id: GO:0000426
name: micropexophagy
namespace: biological_process
def: "Degradation of a peroxisome by lysosomal microautophagy." [GOC:autophagy, GOC:pad, PMID:12914914, PMID:15350980, PMID:16973210]
is_a: GO:0016237 ! lysosomal microautophagy
is_a: GO:0030242 ! pexophagy

[Term]
id: GO:0000427
name: plastid-encoded plastid RNA polymerase complex
namespace: cellular_component
def: "An RNA polymerase complex containing polypeptides encoded by the plastid genome. Plastid-encoded DNA-directed RNA polymerases resemble eubacterial multisubunit RNA polymerases, with a core composed of alpha, beta, and beta-prime subunits. Some forms contain multiple additional subunits. An additional sigma factor subunit is required for promoter recognition." [GOC:krc, GOC:mah, GOC:pj]
is_a: GO:0000428 ! DNA-directed RNA polymerase complex
is_a: GO:0044435 ! plastid part
intersection_of: GO:0000428 ! DNA-directed RNA polymerase complex
intersection_of: part_of GO:0009536 ! plastid
relationship: part_of GO:0009536 ! plastid

[Term]
id: GO:0000428
name: DNA-directed RNA polymerase complex
namespace: cellular_component
def: "A protein complex that possesses DNA-directed RNA polymerase activity." [GOC:krc]
is_a: GO:0030880 ! RNA polymerase complex

[Term]
id: GO:0000429
name: carbon catabolite regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A transcription regulation process in which the presence of one carbon source leads to the modulation of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources." [GOC:krc, GOC:mah]
synonym: "regulation of transcription from RNA polymerase II promoter by carbon catabolites" EXACT [GOC:mah]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0045990 ! carbon catabolite regulation of transcription

[Term]
id: GO:0000430
name: regulation of transcription from RNA polymerase II promoter by glucose
namespace: biological_process
def: "Any process involving glucose that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:krc]
is_a: GO:0000429 ! carbon catabolite regulation of transcription from RNA polymerase II promoter
is_a: GO:0046015 ! regulation of transcription by glucose

[Term]
id: GO:0000431
name: regulation of transcription from RNA polymerase II promoter by galactose
namespace: biological_process
def: "Any process involving galactose that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:krc]
is_a: GO:0000409 ! regulation of transcription by galactose
is_a: GO:0000429 ! carbon catabolite regulation of transcription from RNA polymerase II promoter

[Term]
id: GO:0000432
name: positive regulation of transcription from RNA polymerase II promoter by glucose
namespace: biological_process
def: "Any process involving glucose that activates or increases the rate of transcription from an RNA polymerase II promoter." [GOC:krc]
synonym: "activation of transcription from RNA polymerase II promoter by glucose" NARROW []
synonym: "stimulation of transcription from RNA polymerase II promoter by glucose" NARROW []
synonym: "up regulation of transcription from RNA polymerase II promoter by glucose" EXACT []
synonym: "up-regulation of transcription from RNA polymerase II promoter by glucose" EXACT []
synonym: "upregulation of transcription from RNA polymerase II promoter by glucose" EXACT []
is_a: GO:0000430 ! regulation of transcription from RNA polymerase II promoter by glucose
is_a: GO:0000436 ! carbon catabolite activation of transcription from RNA polymerase II promoter
is_a: GO:0046016 ! positive regulation of transcription by glucose

[Term]
id: GO:0000433
name: negative regulation of transcription from RNA polymerase II promoter by glucose
namespace: biological_process
def: "Any process involving glucose that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter." [GOC:krc]
synonym: "down regulation of transcription from RNA polymerase II promoter by glucose" EXACT []
synonym: "down-regulation of transcription from RNA polymerase II promoter by glucose" EXACT []
synonym: "downregulation of transcription from RNA polymerase II promoter by glucose" EXACT []
synonym: "inhibition of transcription from RNA polymerase II promoter by glucose" NARROW []
is_a: GO:0000430 ! regulation of transcription from RNA polymerase II promoter by glucose
is_a: GO:0000437 ! carbon catabolite repression of transcription from RNA polymerase II promoter
is_a: GO:0045014 ! negative regulation of transcription by glucose

[Term]
id: GO:0000434
name: negative regulation of transcription from RNA polymerase II promoter by galactose
namespace: biological_process
def: "Any process involving galactose that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter." [GOC:krc]
synonym: "down regulation of transcription from RNA polymerase II promoter by galactose" EXACT []
synonym: "down-regulation of transcription from RNA polymerase II promoter by galactose" EXACT []
synonym: "downregulation of transcription from RNA polymerase II promoter by galactose" EXACT []
synonym: "inhibition of transcription from RNA polymerase II promoter by galactose" NARROW []
is_a: GO:0000410 ! negative regulation of transcription by galactose
is_a: GO:0000431 ! regulation of transcription from RNA polymerase II promoter by galactose
is_a: GO:0000437 ! carbon catabolite repression of transcription from RNA polymerase II promoter

[Term]
id: GO:0000435
name: positive regulation of transcription from RNA polymerase II promoter by galactose
namespace: biological_process
def: "Any process involving galactose that activates or increases the rate of transcription from an RNA polymerase II promoter." [GOC:krc]
synonym: "activation of transcription from RNA polymerase II promoter by galactose" NARROW []
synonym: "stimulation of transcription from RNA polymerase II promoter by galactose" NARROW []
synonym: "up regulation of transcription from RNA polymerase II promoter by galactose" EXACT []
synonym: "up-regulation of transcription from RNA polymerase II promoter by galactose" EXACT []
synonym: "upregulation of transcription from RNA polymerase II promoter by galactose" EXACT []
is_a: GO:0000411 ! positive regulation of transcription by galactose
is_a: GO:0000431 ! regulation of transcription from RNA polymerase II promoter by galactose
is_a: GO:0000436 ! carbon catabolite activation of transcription from RNA polymerase II promoter

[Term]
id: GO:0000436
name: carbon catabolite activation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process involving carbon catabolites that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:krc]
synonym: "positive regulation of transcription from RNA polymerase II promoter by carbon catabolites" EXACT [GOC:mah]
is_a: GO:0000429 ! carbon catabolite regulation of transcription from RNA polymerase II promoter
is_a: GO:0045991 ! carbon catabolite activation of transcription
is_a: GO:1901522 ! positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus

[Term]
id: GO:0000437
name: carbon catabolite repression of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A transcription regulation process in which the presence of one carbon source leads to a decrease in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources." [GOC:krc]
synonym: "negative regulation of transcription from RNA polymerase II promoter by carbon catabolites" EXACT [GOC:mah]
is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
is_a: GO:0000429 ! carbon catabolite regulation of transcription from RNA polymerase II promoter
is_a: GO:0045013 ! carbon catabolite repression of transcription

[Term]
id: GO:0000438
name: core TFIIH complex portion of holo TFIIH complex
namespace: cellular_component
alt_id: GO:0000443
def: "The core TFIIH complex when it is part of the general transcription factor TFIIH." [GOC:ew, GOC:krc, PMID:14500720, PMID:22308316, PMID:22572993, PMID:7813015]
synonym: "SSL2-core TFIIH complex portion of holo TFIIH complex" EXACT []
is_a: GO:0000439 ! core TFIIH complex
is_a: GO:0044451 ! nucleoplasm part
intersection_of: GO:0000439 ! core TFIIH complex
intersection_of: part_of GO:0005675 ! holo TFIIH complex
relationship: part_of GO:0005675 ! holo TFIIH complex

[Term]
id: GO:0000439
name: core TFIIH complex
namespace: cellular_component
alt_id: GO:0000441
def: "The 7 subunit core of TFIIH that is a part of either the general transcription factor holo-TFIIH or the nucleotide-excision repair factor 3 complex. In S. cerevisiae/humans the complex is composed of: Ssl2/XPB, Tfb1/p62, Tfb2/p52, Ssl1/p44, Tfb4/p34, Tfb5/p8 and Rad3/XPD." [GOC:ew, GOC:krc, PMID:14500720, PMID:17215295, PMID:22308316, PMID:22572993, PMID:23028141, PMID:7813015]
subset: goslim_pir
synonym: "SSL2-core TFIIH complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0000440
name: core TFIIH complex portion of NEF3 complex
namespace: cellular_component
alt_id: GO:0000442
def: "The core TFIIH complex when it is part of the nucleotide-excision repair factor 3 (NEF3)." [GOC:ew, GOC:krc, PMID:14500720, PMID:22308316, PMID:22572993, PMID:7813015]
synonym: "SSL2-core TFIIH complex portion of NEF3 complex" EXACT []
is_a: GO:0000439 ! core TFIIH complex
intersection_of: GO:0000439 ! core TFIIH complex
intersection_of: part_of GO:0000112 ! nucleotide-excision repair factor 3 complex
relationship: part_of GO:0000112 ! nucleotide-excision repair factor 3 complex

[Term]
id: GO:0000444
name: MIS12/MIND type complex
namespace: cellular_component
def: "A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore. It helps to recruit outer kinetochore subunits that will bind to microtubules. In humans, it consists of MIS12, DSN1, NSL1 and PMF1." [GOC:krc, PMID:14633972, PMID:16585270]
synonym: "Mis12 complex" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000777 ! condensed chromosome kinetochore

[Term]
id: GO:0000445
name: THO complex part of transcription export complex
namespace: cellular_component
def: "The THO complex when it is part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp1, and Mft1, while the human complex is composed of 7 subunits." [GOC:krc, PMID:11060033, PMID:11979277, PMID:16983072]
synonym: "THO complex part of TREX complex" EXACT []
is_a: GO:0000347 ! THO complex
intersection_of: GO:0000347 ! THO complex
intersection_of: part_of GO:0000346 ! transcription export complex
relationship: part_of GO:0000346 ! transcription export complex

[Term]
id: GO:0000446
name: nucleoplasmic THO complex
namespace: cellular_component
def: "The THO complex when it is acting as a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp2, and Mft1, while the human complex is composed of 7 subunits." [GOC:krc, GOC:se, PMID:11060033, PMID:11979277, PMID:16983072]
is_a: GO:0000347 ! THO complex
is_a: GO:0008023 ! transcription elongation factor complex

[Term]
id: GO:0000447
name: endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:10690410]
synonym: "endonucleolytic cleavage at A2" NARROW []
is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
relationship: part_of GO:0000462 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

[Term]
id: GO:0000448
name: cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
alt_id: GO:0000490
def: "Endonucleolytic cleavage within ITS2 between the 5.8S rRNA and the LSU-rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:10690410]
synonym: "cleavage at C2" RELATED []
synonym: "cleavage in ITS2 of tricistronic rRNA transcript to separate 5.8S and LSU rRNAs (SSU-rRNA, 5.8S rRNA, LSU-rRNA)" EXACT []
is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
relationship: part_of GO:0000463 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

[Term]
id: GO:0000449
name: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S)
namespace: biological_process
def: "Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5' to 3' along the primary transcript. For example, primary ribosomal RNA transcripts containing three genes, in this order, are produced in E. coli and other prokaryotic species. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators]
is_a: GO:0000478 ! endonucleolytic cleavage involved in rRNA processing

[Term]
id: GO:0000450
name: cleavage of bicistronic rRNA transcript (SSU-rRNA, LSU-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage of pre-rRNAs originally produced as a bicistronic rRNA transcript that contains the SSU-rRNA and the LSU-rRNA in that order from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with two genes in this order are produced in Archaeal species." [GOC:curators]
is_a: GO:0000478 ! endonucleolytic cleavage involved in rRNA processing

[Term]
id: GO:0000451
name: rRNA 2'-O-methylation
namespace: biological_process
def: "The addition of a methyl group to the 2'-oxygen atom of a nucleotide residue in an rRNA molecule during ribosome biogenesis." [GOC:curators, ISBN:1555811337]
is_a: GO:0031167 ! rRNA methylation

[Term]
id: GO:0000452
name: snoRNA guided rRNA 2'-O-methylation
namespace: biological_process
def: "The posttranscriptional addition of methyl groups to the 2'-oxygen atom of nucleotide residues in an rRNA molecule during ribosome biogenesis using a snoRNA guide that targets the position of methylation." [GOC:curators, ISBN:1555811337]
synonym: "snoRNA guided rRNA 2'-O-ribose methylation" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0000451 ! rRNA 2'-O-methylation
is_a: GO:0016074 ! snoRNA metabolic process

[Term]
id: GO:0000453
name: enzyme-directed rRNA 2'-O-methylation
namespace: biological_process
def: "The addition of methyl groups to the 2'-oxygen atom of nucleotide residues in an rRNA molecule during ribosome biogenesis where the methylase specifies the site that becomes methylated without using a guide RNA." [GOC:curators, ISBN:1555811337]
is_a: GO:0000451 ! rRNA 2'-O-methylation

[Term]
id: GO:0000454
name: snoRNA guided rRNA pseudouridine synthesis
namespace: biological_process
def: "The intramolecular conversion of uridine to pseudouridine in an rRNA molecule during ribosome biogenesis using a snoRNA guide that targets the position of pseudouridylation." [GOC:curators, ISBN:1555811337]
is_a: GO:0016074 ! snoRNA metabolic process
is_a: GO:0031118 ! rRNA pseudouridine synthesis

[Term]
id: GO:0000455
name: enzyme-directed rRNA pseudouridine synthesis
namespace: biological_process
def: "The intramolecular conversion of uridine to pseudouridine during ribosome biogenesis where the enzyme specifies the site that becomes pseudouridylated without using a guide RNA." [GOC:curators, ISBN:1555811337]
is_a: GO:0031118 ! rRNA pseudouridine synthesis

[Term]
id: GO:0000456
name: dimethylation involved in SSU-rRNA maturation
namespace: biological_process
def: "Dimethylation of the N6 amino groups of two consecutive adenosine residues near the 3'-end of the SSU rRNA. This process has been conserved from bacteria to eukaryotes." [GOC:curators, GOC:dph, GOC:tb, ISBN:1555811337]
is_a: GO:0031167 ! rRNA methylation
relationship: part_of GO:0030490 ! maturation of SSU-rRNA

[Term]
id: GO:0000457
name: endonucleolytic cleavage between SSU-rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S)
namespace: biological_process
def: "Endonucleolytic cleavage to separate a pre-SSU-rRNA from a pre-LSU-rRNA originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5' to 3' along the primary transcript. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators]
is_a: GO:0000449 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S)
relationship: part_of GO:0002108 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S)
relationship: part_of GO:0002109 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S)

[Term]
id: GO:0000458
name: endonucleolytic cleavage between LSU-rRNA and 5S rRNA of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S)
namespace: biological_process
def: "Endonucleolytic cleavage to separate a pre-LSU-rRNA from a pre-5S rRNA originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5' to 3' along the primary transcript. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators]
is_a: GO:0000449 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S)
relationship: part_of GO:0002108 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S)

[Term]
id: GO:0000459
name: exonucleolytic trimming involved in rRNA processing
namespace: biological_process
def: "Exonucleolytic digestion of a pre-rRNA molecule in the process to generate a mature rRNA molecule." [GOC:curators]
synonym: "exonucleolytic trimming during rRNA processing" RELATED [GOC:dph, GOC:tb]
is_a: GO:0000469 ! cleavage involved in rRNA processing
is_a: GO:0090503 ! RNA phosphodiester bond hydrolysis, exonucleolytic
intersection_of: GO:0090503 ! RNA phosphodiester bond hydrolysis, exonucleolytic
intersection_of: part_of GO:0006364 ! rRNA processing
relationship: part_of GO:0006364 ! rRNA processing

[Term]
id: GO:0000460
name: maturation of 5.8S rRNA
namespace: biological_process
def: "Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule." [GOC:curators]
is_a: GO:0006364 ! rRNA processing

[Term]
id: GO:0000461
name: endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage at the 3'-end of the SSU-rRNA from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA." [GOC:krc, PMID:10690410]
synonym: "endonucleolytic cleavage at site D" NARROW []
is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
is_a: GO:0031125 ! rRNA 3'-end processing
relationship: part_of GO:0000462 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

[Term]
id: GO:0000462
name: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
alt_id: GO:1990041
def: "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators]
synonym: "maturation of 18S rRNA" NARROW []
is_a: GO:0030490 ! maturation of SSU-rRNA

[Term]
id: GO:0000463
name: maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators]
is_a: GO:0000470 ! maturation of LSU-rRNA

[Term]
id: GO:0000464
name: endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage within Internal Transcribed Spacer 1 (ITS1) upstream of the 5.8S rRNA derived from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. In S. cerevisiae, this endonucleolytic cleavage within ITS1 initiates the maturation of the LSU and the 5.8S rRNAs." [GOC:krc, PMID:10690410]
synonym: "endonucleolytic cleavage at A3" NARROW []
is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
relationship: part_of GO:0000463 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

[Term]
id: GO:0000465
name: exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 5'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript." [GOC:krc, PMID:10690410]
is_a: GO:0000459 ! exonucleolytic trimming involved in rRNA processing
is_a: GO:0000967 ! rRNA 5'-end processing
relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

[Term]
id: GO:0000466
name: maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Any process involved in the maturation of an rRNA molecule originally produced as part of a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:10690410]
is_a: GO:0000460 ! maturation of 5.8S rRNA

[Term]
id: GO:0000467
name: exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 3'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript." [GOC:krc, PMID:10690410]
is_a: GO:0000459 ! exonucleolytic trimming involved in rRNA processing
is_a: GO:0031125 ! rRNA 3'-end processing
relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

[Term]
id: GO:0000468
name: generation of mature 3'-end of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Any process involved in generating the mature 3'-end of an LSU-rRNA derived from a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:krc, PMID:10690410]
synonym: "processing at B2" NARROW []
is_a: GO:0031125 ! rRNA 3'-end processing
relationship: part_of GO:0000463 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

[Term]
id: GO:0000469
name: cleavage involved in rRNA processing
namespace: biological_process
def: "Any phosphodiester bond hydrolysis involved in the conversion of a primary ribosomal RNA (rRNA) transcript into a mature rRNA molecule." [GOC:curators]
synonym: "cleavage during rRNA processing" RELATED [GOC:dph, GOC:tb]
is_a: GO:0090501 ! RNA phosphodiester bond hydrolysis
intersection_of: GO:0090501 ! RNA phosphodiester bond hydrolysis
intersection_of: part_of GO:0006364 ! rRNA processing
relationship: part_of GO:0006364 ! rRNA processing

[Term]
id: GO:0000470
name: maturation of LSU-rRNA
namespace: biological_process
def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule." [GOC:curators]
is_a: GO:0006364 ! rRNA processing
relationship: part_of GO:0042273 ! ribosomal large subunit biogenesis

[Term]
id: GO:0000471
name: endonucleolytic cleavage in 3'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage within the 3'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. In S. cerevisiae, endonucleolytic cleavage within the 3'-ETS of the pre-RNA, which may occur cotranscriptionally, is the first step in rRNA processing, and initiates a cascade of subsequent processing and modification events." [GOC:krc, PMID:10690410]
is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

[Term]
id: GO:0000472
name: endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage between the 5'-External Transcribed Spacer (5'-ETS) and the 5' end of the SSU-rRNA of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA." [GOC:curators, PMID:10690410]
synonym: "endonucleolytic cleavage at A1" NARROW []
is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
is_a: GO:0000967 ! rRNA 5'-end processing
relationship: part_of GO:0000462 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

[Term]
id: GO:0000473
name: maturation of LSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
namespace: biological_process
def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8 S rRNA, 2S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators]
is_a: GO:0000470 ! maturation of LSU-rRNA

[Term]
id: GO:0000474
name: maturation of SSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
namespace: biological_process
def: "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8 S rRNA, 2S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators]
is_a: GO:0030490 ! maturation of SSU-rRNA

[Term]
id: GO:0000475
name: maturation of 2S rRNA
namespace: biological_process
def: "Any process involved in the maturation of a precursor 2S ribosomal RNA (rRNA) molecule into a mature 2S rRNA molecule." [GOC:curators]
is_a: GO:0006364 ! rRNA processing

[Term]
id: GO:0000476
name: maturation of 4.5S rRNA
namespace: biological_process
def: "Any process involved in the maturation of a precursor 4.5S ribosomal RNA (rRNA) molecule into a mature 4.5S rRNA molecule." [GOC:curators]
is_a: GO:0006364 ! rRNA processing

[Term]
id: GO:0000477
name: generation of mature 5'-end of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Cleavage within ITS2 to generate the mature 5'-end of an LSU-rRNA derived from a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:10690410]
synonym: "processing at C1" NARROW []
is_a: GO:0000469 ! cleavage involved in rRNA processing
is_a: GO:0000967 ! rRNA 5'-end processing
relationship: part_of GO:0000463 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

[Term]
id: GO:0000478
name: endonucleolytic cleavage involved in rRNA processing
namespace: biological_process
def: "Any endonucleolytic cleavage involved in the conversion of a primary ribosomal RNA (rRNA) transcript into a mature rRNA molecule. Some endonucleolytic cleavages produce the mature end, while others are a step in the process of generating the mature end from the pre-rRNA." [GOC:krc, PMID:10690410]
synonym: "endonucleolytic cleavage during rRNA processing" RELATED [GOC:dph, GOC:tb]
is_a: GO:0000469 ! cleavage involved in rRNA processing
is_a: GO:0090502 ! RNA phosphodiester bond hydrolysis, endonucleolytic
intersection_of: GO:0090502 ! RNA phosphodiester bond hydrolysis, endonucleolytic
intersection_of: part_of GO:0006364 ! rRNA processing
relationship: part_of GO:0006364 ! rRNA processing

[Term]
id: GO:0000479
name: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with three genes, in this order, are produced in the nuclei of many eukaryotic species, including S. cerevisiae." [GOC:curators, PMID:10690410]
is_a: GO:0000478 ! endonucleolytic cleavage involved in rRNA processing

[Term]
id: GO:0000480
name: endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage within the 5'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. Endonucleolytic cleavage within the 5'-ETS of the pre-RNA is conserved as one of the early steps of rRNA processing in all eukaryotes, but the specific position of cleavage is variable." [GOC:curators, PMID:10690410, PMID:15282326]
synonym: "endonucleolytic cleavage at A-prime" NARROW [PMID:15282326]
synonym: "endonucleolytic cleavage at A0" NARROW []
is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
relationship: part_of GO:0000462 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

[Term]
id: GO:0000481
name: maturation of 5S rRNA
namespace: biological_process
def: "Any process involved in the maturation of a precursor 5S ribosomal RNA (rRNA) molecule into a mature 5S rRNA molecule." [GOC:curators]
is_a: GO:0006364 ! rRNA processing

[Term]
id: GO:0000482
name: maturation of 5S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Any process involved in the maturation of a precursor 5S ribosomal RNA (rRNA) molecule into a mature 5S rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators]
is_a: GO:0000481 ! maturation of 5S rRNA

[Term]
id: GO:0000483
name: endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with four genes, in this order, are produced in the nuclei of D. melanogaster as well as in those of other dipteran species." [GOC:curators]
is_a: GO:0000478 ! endonucleolytic cleavage involved in rRNA processing

[Term]
id: GO:0000484
name: cleavage between SSU-rRNA and 5.8S rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators]
is_a: GO:0000483 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
relationship: part_of GO:0000474 ! maturation of SSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
relationship: part_of GO:0000487 ! maturation of 5.8S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)

[Term]
id: GO:0000485
name: cleavage between 2S rRNA and LSU-rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage between the LSU-rRNA and the 2S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:768488]
is_a: GO:0000483 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
relationship: part_of GO:0000473 ! maturation of LSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
relationship: part_of GO:0000475 ! maturation of 2S rRNA

[Term]
id: GO:0000486
name: cleavage between 5.8S rRNA and 2S rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage between the 5.8S rRNA and the 2S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:768488]
is_a: GO:0000483 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
relationship: part_of GO:0000475 ! maturation of 2S rRNA
relationship: part_of GO:0000487 ! maturation of 5.8S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)

[Term]
id: GO:0000487
name: maturation of 5.8S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
namespace: biological_process
def: "Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 8.8S rRNA, the 2S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators]
is_a: GO:0000460 ! maturation of 5.8S rRNA

[Term]
id: GO:0000488
name: maturation of LSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)
namespace: biological_process
def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators]
is_a: GO:0000470 ! maturation of LSU-rRNA

[Term]
id: GO:0000489
name: maturation of SSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)
namespace: biological_process
def: "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators]
is_a: GO:0030490 ! maturation of SSU-rRNA

[Term]
id: GO:0000491
name: small nucleolar ribonucleoprotein complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins and a snoRNA to form a small nucleolar ribonucleoprotein (snoRNP) complex." [GOC:krc]
synonym: "snoRNP assembly" EXACT []
is_a: GO:0022618 ! ribonucleoprotein complex assembly

[Term]
id: GO:0000492
name: box C/D snoRNP assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins and a box C/D snoRNA to form a box C/D small nucleolar ribonucleoprotein (snoRNP) complex." [GOC:krc]
synonym: "box C/D small nucleolar ribonucleoprotein complex assembly" EXACT []
is_a: GO:0000491 ! small nucleolar ribonucleoprotein complex assembly

[Term]
id: GO:0000493
name: box H/ACA snoRNP assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins and a box H/ACA snoRNA to form a box H/ACA small nucleolar ribonucleoprotein (snoRNP) complex." [GOC:krc, PMID:12515383]
synonym: "box H/ACA small nucleolar ribonucleoprotein complex assembly" EXACT []
is_a: GO:0000491 ! small nucleolar ribonucleoprotein complex assembly

[Term]
id: GO:0000494
name: box C/D snoRNA 3'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 3' end of a box C/D snoRNA molecule." [GOC:krc]
synonym: "box C/D snoRNA 3' end processing" EXACT []
is_a: GO:0031126 ! snoRNA 3'-end processing
is_a: GO:0034963 ! box C/D snoRNA processing

[Term]
id: GO:0000495
name: box H/ACA snoRNA 3'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 3' end of a box H/ACA snoRNA molecule." [GOC:krc]
synonym: "box H/ACA snoRNA 3' end processing" EXACT []
is_a: GO:0031126 ! snoRNA 3'-end processing
is_a: GO:0034964 ! box H/ACA snoRNA processing

[Term]
id: GO:0000496
name: base pairing
namespace: molecular_function
def: "Interacting selectively and non-covalently with nucleic acid via hydrogen bonds between the bases of a gene product molecule and the bases of a target nucleic acid molecule." [GOC:krc]
comment: Note that with respect to annotation, "base pairing" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other nucleic acid molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function.
xref: Wikipedia:Base_pair
is_a: GO:0003676 ! nucleic acid binding

[Term]
id: GO:0000497
name: base pairing with DNA
namespace: molecular_function
def: "Interacting selectively and non-covalently with nucleic acid via hydrogen bonds between the bases of a gene product molecule and the bases of a target DNA molecule." [GOC:krc]
comment: Note that with respect to annotation, "base pairing" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with DNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function.
is_a: GO:0000496 ! base pairing
is_a: GO:0003677 ! DNA binding

[Term]
id: GO:0000498
name: base pairing with RNA
namespace: molecular_function
def: "Interacting selectively and non-covalently with ribonucleic acid (RNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target RNA molecule." [GOC:krc]
comment: Note that with respect to annotation, "base pairing with RNA" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other RNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function.
is_a: GO:0000496 ! base pairing
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0000499
name: base pairing with mRNA
namespace: molecular_function
def: "Interacting selectively and non-covalently with messenger ribonucleic acid (mRNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target mRNA molecule." [GOC:krc]
comment: Note that with respect to annotation, "base pairing with RNA" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other RNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function.
is_a: GO:0000498 ! base pairing with RNA

[Term]
id: GO:0000500
name: RNA polymerase I upstream activating factor complex
namespace: cellular_component
def: "A complex required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrrn5p, Rrn9p, Rrn10p, histones H3 and H4, and Uaf30p." [PMID:11500378]
synonym: "RNA polymerase I upstream activation factor complex" EXACT []
synonym: "UAF" EXACT []
is_a: GO:0000120 ! RNA polymerase I transcription factor complex

[Term]
id: GO:0000501
name: flocculation via cell wall protein-carbohydrate interaction
namespace: biological_process
def: "The reversible, non-sexual aggregation of cells mediated by the binding of proteins in the cell wall of one cell to carbohydrates in the cell wall of another cell.  An example of this process is found in Saccharomyces cerevisiae, in which it is pH- and calcium-dependent." [GOC:mcc, GOC:sgd_curators, GOC:vw, PMID:21114594]
subset: gosubset_prok
is_a: GO:0000128 ! flocculation

[Term]
id: GO:0000502
name: proteasome complex
namespace: cellular_component
def: "A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb, http://en.wikipedia.org/wiki/Proteasome]
subset: goslim_pir
synonym: "26S proteasome" NARROW []
synonym: "proteasome" EXACT [GOC:cjm]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0000504
name: obsolete proteasome regulatory particle (sensu Bacteria)
namespace: cellular_component
def: "OBSOLETE. A multisubunit complex that recognizes and unfolds ubiquitinated proteins, and translocates them to the core complex in an ATP dependent manner. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [GOC:rb]
comment: This term was made obsolete because there is no ubiquitin in bacteria and they do not have proteasome regulatory particles. Instead they have proteasome-activating nucleotidase.
synonym: "26S proteasome" NARROW []
synonym: "proteasome regulatory particle (sensu Bacteria)" EXACT []
is_obsolete: true

[Term]
id: GO:0000506
name: glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI anchors for cell surface proteins. The complex contains PIG-A, PIG-C, PIG-H, PIG-Q, PIG-P, and DPM2 in human, and Eri1p, Gpi1p, Gpi2p, Gpi15p, Gpi19p, and Spt14p in budding yeast." [GOC:kp, GOC:rb, PMID:10944123, PMID:15163411]
comment: Note that this term should not be confused with 'GPI-anchor transamidase complex ; GO:0042765', which represents a distinct complex with a different catalytic activity.
synonym: "GPI-GlcNAc transferase complex" EXACT []
synonym: "GPI-GnT complex" EXACT []
synonym: "GPI-N-acetylglucosaminyltransferase complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044432 ! endoplasmic reticulum part

[Term]
id: GO:0000578
name: embryonic axis specification
namespace: biological_process
def: "The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo." [GOC:dph, GOC:go_curators, GOC:sdb_2009, GOC:tb]
synonym: "embryonic axis determination" RELATED []
is_a: GO:0009798 ! axis specification
is_a: GO:0009880 ! embryonic pattern specification

[Term]
id: GO:0000700
name: mismatch base pair DNA N-glycosylase activity
namespace: molecular_function
def: "Catalysis of the removal of single bases present in mismatches by the cleavage the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site." [GOC:elh, PMID:9224623]
is_a: GO:0019104 ! DNA N-glycosylase activity

[Term]
id: GO:0000701
name: purine-specific mismatch base pair DNA N-glycosylase activity
namespace: molecular_function
def: "Catalysis of the removal of purines present in mismatches, especially opposite oxidized purines, by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site." [GOC:elh, PMID:9224623]
synonym: "A/G-specific adenine DNA glycosylase activity" NARROW []
xref: EC:3.2.2.-
is_a: GO:0000700 ! mismatch base pair DNA N-glycosylase activity

[Term]
id: GO:0000702
name: oxidized base lesion DNA N-glycosylase activity
namespace: molecular_function
def: "Catalysis of the removal of oxidized bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site." [GOC:elh, PMID:11554296]
subset: gosubset_prok
is_a: GO:0019104 ! DNA N-glycosylase activity

[Term]
id: GO:0000703
name: oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity
namespace: molecular_function
alt_id: GO:0019004
def: "Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site." [GOC:elh, PMID:11554296]
comment: Consider also annotating to the molecular function term 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906'.
subset: gosubset_prok
synonym: "bifunctional DNA glycosylase" BROAD []
synonym: "DNA glycosylase/AP-lyase" BROAD []
synonym: "DNA glycosylase/beta-lyase" BROAD []
synonym: "endodeoxyribonuclease III" RELATED []
synonym: "endonuclease III" RELATED []
synonym: "endonuclease VIII activity" RELATED []
synonym: "oxidized pyrimidine base lesion DNA N-glycosylase activity" EXACT [GOC:go_curators]
synonym: "pyrimidine-specific oxidized base lesion DNA N-glycosylase activity" RELATED []
xref: Reactome:REACT_101001 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Plasmodium falciparum"
xref: Reactome:REACT_101090 "Cleavage of dihydrouracil by hNTH1 glycosylase, Escherichia coli"
xref: Reactome:REACT_101315 "Cleavage of cytosine glycol by hNTH1 glycosylase, Danio rerio"
xref: Reactome:REACT_101744 "Cleavage of thymine glycol by hNTH1 glycosylase, Mus musculus"
xref: Reactome:REACT_102306 "Cleavage of cytosine glycol by hNTH1 glycosylase, Schizosaccharomyces pombe"
xref: Reactome:REACT_103688 "Cleavage of thymine glycol by hNTH1 glycosylase, Gallus gallus"
xref: Reactome:REACT_103837 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Saccharomyces cerevisiae"
xref: Reactome:REACT_104179 "Cleavage of cytosine glycol by hNTH1 glycosylase, Oryza sativa"
xref: Reactome:REACT_104266 "Cleavage of thymine glycol by hNTH1 glycosylase, Saccharomyces cerevisiae"
xref: Reactome:REACT_104313 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Staphylococcus aureus N315"
xref: Reactome:REACT_105538 "Cleavage of cytosine glycol by hNTH1 glycosylase, Arabidopsis thaliana"
xref: Reactome:REACT_105622 "Cleavage of thymine glycol by hNTH1 glycosylase, Xenopus tropicalis"
xref: Reactome:REACT_105635 "Cleavage of cytosine glycol by hNTH1 glycosylase, Escherichia coli"
xref: Reactome:REACT_105967 "Cleavage of thymine glycol by hNTH1 glycosylase, Schizosaccharomyces pombe"
xref: Reactome:REACT_106253 "Cleavage of thymine glycol by hNTH1 glycosylase, Taeniopygia guttata"
xref: Reactome:REACT_107207 "Cleavage of cytosine glycol by hNTH1 glycosylase, Bos taurus"
xref: Reactome:REACT_107703 "Cleavage of dihydrouracil by hNTH1 glycosylase, Taeniopygia guttata"
xref: Reactome:REACT_107763 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Danio rerio"
xref: Reactome:REACT_108637 "Cleavage of cytosine glycol by hNTH1 glycosylase, Canis familiaris"
xref: Reactome:REACT_108860 "Cleavage of dihydrouracil by hNTH1 glycosylase, Mycobacterium tuberculosis"
xref: Reactome:REACT_109023 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Bos taurus"
xref: Reactome:REACT_109743 "Cleavage of cytosine glycol by hNTH1 glycosylase, Gallus gallus"
xref: Reactome:REACT_2021 "Cleavage of cytosine glycol by hNTH1 glycosylase, Homo sapiens"
xref: Reactome:REACT_2157 "Cleavage of dihydrouracil by hNTH1 glycosylase, Homo sapiens"
xref: Reactome:REACT_2255 "Cleavage of thymine glycol by hNTH1 glycosylase, Homo sapiens"
xref: Reactome:REACT_28127 "Cleavage of cytosine glycol by hNTH1 glycosylase, Mus musculus"
xref: Reactome:REACT_28180 "Cleavage of thymine glycol by hNTH1 glycosylase, Caenorhabditis elegans"
xref: Reactome:REACT_29323 "Cleavage of dihydrouracil by hNTH1 glycosylase, Schizosaccharomyces pombe"
xref: Reactome:REACT_29518 "Cleavage of cytosine glycol by hNTH1 glycosylase, Xenopus tropicalis"
xref: Reactome:REACT_30621 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Mus musculus"
xref: Reactome:REACT_30642 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Oryza sativa"
xref: Reactome:REACT_30750 "Cleavage of dihydrouracil by hNTH1 glycosylase, Arabidopsis thaliana"
xref: Reactome:REACT_32240 "Cleavage of cytosine glycol by hNTH1 glycosylase, Drosophila melanogaster"
xref: Reactome:REACT_32421 "Cleavage of thymine glycol by hNTH1 glycosylase, Danio rerio"
xref: Reactome:REACT_32931 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Escherichia coli"
xref: Reactome:REACT_33078 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Taeniopygia guttata"
xref: Reactome:REACT_33307 "Cleavage of cytosine glycol by hNTH1 glycosylase, Dictyostelium discoideum"
xref: Reactome:REACT_33417 "Cleavage of cytosine glycol by hNTH1 glycosylase, Plasmodium falciparum"
xref: Reactome:REACT_33820 "Cleavage of thymine glycol by hNTH1 glycosylase, Bos taurus"
xref: Reactome:REACT_33839 "Cleavage of thymine glycol by hNTH1 glycosylase, Arabidopsis thaliana"
xref: Reactome:REACT_33951 "Cleavage of dihydrouracil by hNTH1 glycosylase, Drosophila melanogaster"
xref: Reactome:REACT_34296 "Cleavage of dihydrouracil by hNTH1 glycosylase, Xenopus tropicalis"
xref: Reactome:REACT_77336 "Cleavage of cytosine glycol by hNTH1 glycosylase, Rattus norvegicus"
xref: Reactome:REACT_77526 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Dictyostelium discoideum"
xref: Reactome:REACT_78108 "Cleavage of cytosine glycol by hNTH1 glycosylase, Mycobacterium tuberculosis"
xref: Reactome:REACT_78298 "Cleavage of dihydrouracil by hNTH1 glycosylase, Saccharomyces cerevisiae"
xref: Reactome:REACT_78343 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Sus scrofa"
xref: Reactome:REACT_78458 "Cleavage of dihydrouracil by hNTH1 glycosylase, Danio rerio"
xref: Reactome:REACT_78529 "Cleavage of dihydrouracil by hNTH1 glycosylase, Gallus gallus"
xref: Reactome:REACT_79663 "Cleavage of dihydrouracil by hNTH1 glycosylase, Dictyostelium discoideum"
xref: Reactome:REACT_79864 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Arabidopsis thaliana"
xref: Reactome:REACT_80155 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Schizosaccharomyces pombe"
xref: Reactome:REACT_81464 "Cleavage of dihydrouracil by hNTH1 glycosylase, Rattus norvegicus"
xref: Reactome:REACT_81531 "Cleavage of thymine glycol by hNTH1 glycosylase, Oryza sativa"
xref: Reactome:REACT_82850 "Cleavage of dihydrouracil by hNTH1 glycosylase, Sus scrofa"
xref: Reactome:REACT_83701 "Cleavage of thymine glycol by hNTH1 glycosylase, Dictyostelium discoideum"
xref: Reactome:REACT_83784 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Gallus gallus"
xref: Reactome:REACT_84042 "Cleavage of dihydrouracil by hNTH1 glycosylase, Plasmodium falciparum"
xref: Reactome:REACT_84141 "Cleavage of cytosine glycol by hNTH1 glycosylase, Caenorhabditis elegans"
xref: Reactome:REACT_84471 "Cleavage of dihydrouracil by hNTH1 glycosylase, Staphylococcus aureus N315"
xref: Reactome:REACT_85485 "Cleavage of dihydrouracil by hNTH1 glycosylase, Oryza sativa"
xref: Reactome:REACT_87055 "Cleavage of cytosine glycol by hNTH1 glycosylase, Saccharomyces cerevisiae"
xref: Reactome:REACT_87146 "Cleavage of cytosine glycol by hNTH1 glycosylase, Sus scrofa"
xref: Reactome:REACT_87389 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Caenorhabditis elegans"
xref: Reactome:REACT_87494 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Mycobacterium tuberculosis"
xref: Reactome:REACT_87850 "Cleavage of thymine glycol by hNTH1 glycosylase, Rattus norvegicus"
xref: Reactome:REACT_87925 "Cleavage of dihydrouracil by hNTH1 glycosylase, Caenorhabditis elegans"
xref: Reactome:REACT_890 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Homo sapiens"
xref: Reactome:REACT_89137 "Cleavage of dihydrouracil by hNTH1 glycosylase, Bos taurus"
xref: Reactome:REACT_89396 "Cleavage of cytosine glycol by hNTH1 glycosylase, Taeniopygia guttata"
xref: Reactome:REACT_90163 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Drosophila melanogaster"
xref: Reactome:REACT_90552 "Cleavage of thymine glycol by hNTH1 glycosylase, Canis familiaris"
xref: Reactome:REACT_92193 "Cleavage of dihydrouracil by hNTH1 glycosylase, Canis familiaris"
xref: Reactome:REACT_92466 "Cleavage of cytosine glycol by hNTH1 glycosylase, Staphylococcus aureus N315"
xref: Reactome:REACT_93244 "Cleavage of thymine glycol by hNTH1 glycosylase, Sus scrofa"
xref: Reactome:REACT_93473 "Cleavage of dihydrouracil by hNTH1 glycosylase, Mus musculus"
xref: Reactome:REACT_94304 "Cleavage of thymine glycol by hNTH1 glycosylase, Staphylococcus aureus N315"
xref: Reactome:REACT_95145 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Rattus norvegicus"
xref: Reactome:REACT_96277 "Cleavage of thymine glycol by hNTH1 glycosylase, Escherichia coli"
xref: Reactome:REACT_96754 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Xenopus tropicalis"
xref: Reactome:REACT_97913 "Cleavage of thymine glycol by hNTH1 glycosylase, Drosophila melanogaster"
xref: Reactome:REACT_97922 "Cleavage of thymine glycol by hNTH1 glycosylase, Plasmodium falciparum"
xref: Reactome:REACT_98089 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Canis familiaris"
xref: Reactome:REACT_99032 "Cleavage of thymine glycol by hNTH1 glycosylase, Mycobacterium tuberculosis"
is_a: GO:0000702 ! oxidized base lesion DNA N-glycosylase activity
is_a: GO:0003906 ! DNA-(apurinic or apyrimidinic site) lyase activity

[Term]
id: GO:0000704
name: pyrimidine dimer DNA N-glycosylase activity
namespace: molecular_function
def: "Catalysis of the removal of pyrimidine dimers by removing the 5' pyrimidine of the dimer by cleaving the N-C1' glycosidic bond between the 5' pyrimidine of the dimer and the deoxyribose sugar. The reaction releases the 5' pyrimidine of the dimer and leaves an apurinic (AP) site. The reaction involves the formation of a covalent enzyme substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site." [GOC:elh, PMID:9224623]
is_a: GO:0003906 ! DNA-(apurinic or apyrimidinic site) lyase activity
is_a: GO:0019104 ! DNA N-glycosylase activity

[Term]
id: GO:0000705
name: achiasmate meiosis I
namespace: biological_process
def: "The first division of meiosis in which homologous chromosomes are paired and segregated from each other, occurring in the constitutive absence of chiasmata." [GOC:elh, GOC:sart, PMID:10690419]
is_a: GO:0007127 ! meiosis I

[Term]
id: GO:0000706
name: meiotic DNA double-strand break processing
namespace: biological_process
def: "The cell cycle process in which the 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang occurs. This takes place during meiosis." [GOC:elh, PMID:9334324]
is_a: GO:0000729 ! DNA double-strand break processing
is_a: GO:0044712 ! single-organism catabolic process
is_a: GO:1903046 ! meiotic cell cycle process
intersection_of: GO:0000729 ! DNA double-strand break processing
intersection_of: part_of GO:0051321 ! meiotic cell cycle
relationship: part_of GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0000707
name: meiotic DNA recombinase assembly
namespace: biological_process
def: "During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form higher order oligomers on single-stranded DNA." [GOC:elh, PMID:11459983]
is_a: GO:0000730 ! DNA recombinase assembly
is_a: GO:1903046 ! meiotic cell cycle process
intersection_of: GO:0000730 ! DNA recombinase assembly
intersection_of: part_of GO:0051321 ! meiotic cell cycle
relationship: part_of GO:0007127 ! meiosis I
relationship: part_of GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0000708
name: meiotic strand invasion
namespace: biological_process
def: "The cell cycle process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules. This occurs during meiosis." [GOC:elh, PMID:10915877]
synonym: "meiotic D-loop biosynthesis" RELATED []
synonym: "meiotic D-loop formation" RELATED []
synonym: "meiotic displacement loop biosynthesis" RELATED [GOC:mah, GOC:vw]
synonym: "meiotic displacement loop formation" RELATED [GOC:mah, GOC:vw]
is_a: GO:0042148 ! strand invasion
is_a: GO:0044710 ! single-organism metabolic process
is_a: GO:1903046 ! meiotic cell cycle process
intersection_of: GO:0042148 ! strand invasion
intersection_of: part_of GO:0051321 ! meiotic cell cycle
relationship: part_of GO:0007127 ! meiosis I
relationship: part_of GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0000709
name: meiotic joint molecule formation
namespace: biological_process
def: "The conversion of the paired broken DNA and homologous duplex DNA into a four-stranded branched intermediate, known as a joint molecule, formed during meiotic recombination. These joint molecules contain Holliday junctions on either side of heteroduplex DNA." [GOC:elh, PMID:8521495]
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0007131 ! reciprocal meiotic recombination

[Term]
id: GO:0000710
name: meiotic mismatch repair
namespace: biological_process
def: "A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules. Correction of the mismatch can result in non-Mendelian segregation of alleles following meiosis." [GOC:elh, PMID:10357855]
is_a: GO:0006298 ! mismatch repair
is_a: GO:1903046 ! meiotic cell cycle process
intersection_of: GO:0006298 ! mismatch repair
intersection_of: part_of GO:0051321 ! meiotic cell cycle
relationship: part_of GO:0007127 ! meiosis I
relationship: part_of GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0000711
name: meiotic DNA repair synthesis
namespace: biological_process
def: "During meiosis, the synthesis of DNA proceeding from the broken 3' single-strand DNA end that uses the homologous intact duplex as the template." [GOC:elh, PMID:9334324]
is_a: GO:0000731 ! DNA synthesis involved in DNA repair
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0007127 ! meiosis I

[Term]
id: GO:0000712
name: resolution of meiotic recombination intermediates
namespace: biological_process
def: "The cleavage and rejoining of intermediates, such as Holliday junctions, formed during meiotic recombination to produce two intact molecules in which genetic material has been exchanged." [GOC:elh, PMID:11733053]
synonym: "resolution of meiotic joint molecules as recombinants" NARROW [GOC:elh, GOC:mah]
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0007131 ! reciprocal meiotic recombination
relationship: part_of GO:0051307 ! meiotic chromosome separation

[Term]
id: GO:0000713
name: meiotic heteroduplex formation
namespace: biological_process
def: "During meiosis, the formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules." [GOC:elh, PMID:9334324]
is_a: GO:0030491 ! heteroduplex formation
is_a: GO:0044710 ! single-organism metabolic process
is_a: GO:1903046 ! meiotic cell cycle process
intersection_of: GO:0030491 ! heteroduplex formation
intersection_of: part_of GO:0051321 ! meiotic cell cycle
relationship: part_of GO:0006310 ! DNA recombination
relationship: part_of GO:0007127 ! meiosis I
relationship: part_of GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0000714
name: meiotic strand displacement
namespace: biological_process
def: "The cell cycle process in which the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA is rejected. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules. This occurs during meiosis." [GOC:elh, PMID:10357855]
synonym: "meiotic D-loop dissociation" RELATED [GOC:mah, GOC:vw]
synonym: "meiotic D-loop processing" RELATED [GOC:mah, GOC:vw]
synonym: "meiotic displacement loop dissociation" RELATED [GOC:mah, GOC:vw]
synonym: "meiotic displacement loop processing" RELATED [GOC:mah, GOC:vw]
is_a: GO:0000732 ! strand displacement
is_a: GO:0044710 ! single-organism metabolic process
is_a: GO:1903046 ! meiotic cell cycle process
intersection_of: GO:0000732 ! strand displacement
intersection_of: part_of GO:0051321 ! meiotic cell cycle
relationship: part_of GO:0007127 ! meiosis I
relationship: part_of GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0000715
name: nucleotide-excision repair, DNA damage recognition
namespace: biological_process
def: "The identification of lesions in DNA, such as pyrimidine-dimers, intrastrand cross-links, and bulky adducts. The wide range of substrate specificity suggests the repair complex recognizes distortions in the DNA helix." [GOC:elh, PMID:10197977]
subset: gosubset_prok
synonym: "pyrimidine-dimer repair, DNA damage recognition" RELATED []
xref: Reactome:REACT_107456 "DNA Damage Recognition in GG-NER, Drosophila melanogaster"
xref: Reactome:REACT_112311 "DNA Damage Recognition in GG-NER, Caenorhabditis elegans"
xref: Reactome:REACT_115249 "DNA Damage Recognition in GG-NER, Xenopus tropicalis"
xref: Reactome:REACT_115544 "DNA damage recognition in global genomic repair, Gallus gallus"
xref: Reactome:REACT_29640 "DNA Damage Recognition in GG-NER, Dictyostelium discoideum"
xref: Reactome:REACT_30130 "DNA Damage Recognition in GG-NER, Rattus norvegicus"
xref: Reactome:REACT_31764 "DNA Damage Recognition in GG-NER, Taeniopygia guttata"
xref: Reactome:REACT_476 "DNA Damage Recognition in GG-NER, Homo sapiens"
xref: Reactome:REACT_77558 "DNA Damage Recognition in GG-NER, Danio rerio"
xref: Reactome:REACT_81184 "DNA Damage Recognition in GG-NER, Bos taurus"
xref: Reactome:REACT_82635 "DNA Damage Recognition in GG-NER, Canis familiaris"
xref: Reactome:REACT_86796 "DNA Damage Recognition in GG-NER, Gallus gallus"
xref: Reactome:REACT_89770 "DNA Damage Recognition in GG-NER, Arabidopsis thaliana"
xref: Reactome:REACT_92224 "DNA Damage Recognition in GG-NER, Mus musculus"
xref: Reactome:REACT_94418 "DNA Damage Recognition in GG-NER, Sus scrofa"
xref: Reactome:REACT_95988 "DNA Damage Recognition in GG-NER, Saccharomyces cerevisiae"
xref: Reactome:REACT_97740 "DNA Damage Recognition in GG-NER, Oryza sativa"
xref: Reactome:REACT_98000 "DNA Damage Recognition in GG-NER, Schizosaccharomyces pombe"
is_a: GO:0051276 ! chromosome organization
relationship: part_of GO:0006289 ! nucleotide-excision repair

[Term]
id: GO:0000716
name: transcription-coupled nucleotide-excision repair, DNA damage recognition
namespace: biological_process
def: "The identification of lesions on the actively transcribed strand of the DNA duplex as well as a small subset of lesions not recognized by the general nucleotide-excision repair pathway." [GOC:elh, PMID:10197977]
subset: gosubset_prok
synonym: "pyrimidine-dimer repair, DNA damage recognition" RELATED []
xref: Reactome:REACT_100470 "RNA Pol II is blocked by the lesion leading to reduced transcription, Plasmodium falciparum"
xref: Reactome:REACT_100673 "RNA Pol II is blocked by the lesion leading to reduced transcription, Dictyostelium discoideum"
xref: Reactome:REACT_100817 "RNA Pol II is blocked by the lesion leading to reduced transcription, Mus musculus"
xref: Reactome:REACT_101583 "RNA Pol II is blocked by the lesion leading to reduced transcription, Drosophila melanogaster"
xref: Reactome:REACT_103224 "RNA Pol II is blocked by the lesion leading to reduced transcription, Saccharomyces cerevisiae"
xref: Reactome:REACT_104426 "RNA Pol II is blocked by the lesion leading to reduced transcription, Oryza sativa"
xref: Reactome:REACT_106854 "RNA Pol II is blocked by the lesion leading to reduced transcription, Schizosaccharomyces pombe"
xref: Reactome:REACT_1947 "RNA Pol II is blocked by the lesion leading to reduced transcription, Homo sapiens"
xref: Reactome:REACT_78581 "RNA Pol II is blocked by the lesion leading to reduced transcription, Gallus gallus"
xref: Reactome:REACT_78888 "RNA Pol II is blocked by the lesion leading to reduced transcription, Canis familiaris"
xref: Reactome:REACT_80099 "RNA Pol II is blocked by the lesion leading to reduced transcription, Xenopus tropicalis"
xref: Reactome:REACT_86060 "RNA Pol II is blocked by the lesion leading to reduced transcription, Bos taurus"
xref: Reactome:REACT_86572 "RNA Pol II is blocked by the lesion leading to reduced transcription, Taeniopygia guttata"
xref: Reactome:REACT_86848 "RNA Pol II is blocked by the lesion leading to reduced transcription, Caenorhabditis elegans"
xref: Reactome:REACT_88150 "RNA Pol II is blocked by the lesion leading to reduced transcription, Danio rerio"
xref: Reactome:REACT_90318 "RNA Pol II is blocked by the lesion leading to reduced transcription, Arabidopsis thaliana"
xref: Reactome:REACT_96982 "RNA Pol II is blocked by the lesion leading to reduced transcription, Rattus norvegicus"
is_a: GO:0000715 ! nucleotide-excision repair, DNA damage recognition
relationship: part_of GO:0006283 ! transcription-coupled nucleotide-excision repair

[Term]
id: GO:0000717
name: nucleotide-excision repair, DNA duplex unwinding
namespace: biological_process
def: "The unwinding, or local denaturation, of the DNA duplex to create a bubble around the site of the DNA damage." [GOC:elh, PMID:10197977]
subset: gosubset_prok
xref: Reactome:REACT_101247 "Formation of open bubble structure in DNA by helicases, Bos taurus"
xref: Reactome:REACT_101644 "Formation of open bubble structure in DNA by helicases, Oryza sativa"
xref: Reactome:REACT_1033 "Formation of open bubble structure in DNA by helicases, Homo sapiens"
xref: Reactome:REACT_106346 "Formation of open bubble structure in DNA by helicases, Taeniopygia guttata"
xref: Reactome:REACT_107072 "Formation of open bubble structure in DNA by helicases, Mus musculus"
xref: Reactome:REACT_110827 "Formation of open bubble structure in DNA by helicases, Danio rerio"
xref: Reactome:REACT_113177 "Formation of open bubble structure in DNA by helicases, Caenorhabditis elegans"
xref: Reactome:REACT_29217 "Formation of open bubble structure in DNA by helicases, Xenopus tropicalis"
xref: Reactome:REACT_34016 "Formation of open bubble structure in DNA by helicases, Rattus norvegicus"
xref: Reactome:REACT_78462 "Formation of open bubble structure in DNA by helicases, Drosophila melanogaster"
xref: Reactome:REACT_81682 "Formation of open bubble structure in DNA by helicases, Canis familiaris"
xref: Reactome:REACT_83794 "Formation of open bubble structure in DNA by helicases, Gallus gallus"
xref: Reactome:REACT_84565 "Formation of open bubble structure in DNA by helicases, Schizosaccharomyces pombe"
xref: Reactome:REACT_89030 "Formation of open bubble structure in DNA by helicases, Saccharomyces cerevisiae"
xref: Reactome:REACT_95993 "Formation of open bubble structure in DNA by helicases, Arabidopsis thaliana"
xref: Reactome:REACT_98302 "Formation of open bubble structure in DNA by helicases, Sus scrofa"
is_a: GO:0032508 ! DNA duplex unwinding
intersection_of: GO:0032508 ! DNA duplex unwinding
intersection_of: part_of GO:0006289 ! nucleotide-excision repair
relationship: part_of GO:0006289 ! nucleotide-excision repair

[Term]
id: GO:0000718
name: nucleotide-excision repair, DNA damage removal
namespace: biological_process
def: "The removal of the oligonucleotide that contains the DNA damage. The oligonucleotide is formed by dual incisions that flank the site of DNA damage." [GOC:elh, PMID:10197977]
subset: gosubset_prok
xref: Reactome:REACT_102444 "Dual incision reaction in GG-NER, Oryza sativa"
xref: Reactome:REACT_104645 "Dual incision reaction in GG-NER, Taeniopygia guttata"
xref: Reactome:REACT_109019 "Dual incision reaction in GG-NER, Bos taurus"
xref: Reactome:REACT_30192 "Dual incision reaction in GG-NER, Xenopus tropicalis"
xref: Reactome:REACT_311 "Dual incision reaction in GG-NER, Homo sapiens"
xref: Reactome:REACT_31322 "Dual incision reaction in GG-NER, Saccharomyces cerevisiae"
xref: Reactome:REACT_32014 "Dual incision reaction in GG-NER, Danio rerio"
xref: Reactome:REACT_52725 "Dual incision reaction in GG-NER, Gallus gallus"
xref: Reactome:REACT_89200 "Dual incision reaction in GG-NER, Sus scrofa"
xref: Reactome:REACT_90961 "Dual incision reaction in GG-NER, Arabidopsis thaliana"
xref: Reactome:REACT_91383 "Dual incision reaction in GG-NER, Drosophila melanogaster"
xref: Reactome:REACT_92216 "Dual incision reaction in GG-NER, Canis familiaris"
xref: Reactome:REACT_92900 "Dual incision reaction in GG-NER, Rattus norvegicus"
xref: Reactome:REACT_93068 "Dual incision reaction in GG-NER, Schizosaccharomyces pombe"
xref: Reactome:REACT_96787 "Dual incision reaction in GG-NER, Caenorhabditis elegans"
xref: Reactome:REACT_99802 "Dual incision reaction in GG-NER, Mus musculus"
is_a: GO:0044349 ! DNA excision
relationship: part_of GO:0006289 ! nucleotide-excision repair

[Term]
id: GO:0000719
name: photoreactive repair
namespace: biological_process
def: "The repair of UV-induced T-T, C-T and C-C dimers by directly reversing the damage to restore the original pyrimidines." [GOC:elh, PMID:10915863]
subset: gosubset_prok
synonym: "pyrimidine-dimer repair by photolyase" NARROW []
is_a: GO:0006290 ! pyrimidine dimer repair

[Term]
id: GO:0000720
name: pyrimidine dimer repair by nucleotide-excision repair
namespace: biological_process
def: "The repair of UV-induced T-T, C-T, and C-C dimers by the recognition and removal of the damaged DNA strand from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [GOC:elh]
comment: Note that the repair of pyrimidine dimers by nucleotide excision repair involves the same gene products that are involved in general nucleotide excision repair. Consider also annotating to other children of the biological process term 'nucleotide-excision repair ; GO:0006289'.
subset: gosubset_prok
is_a: GO:0006289 ! nucleotide-excision repair
is_a: GO:0006290 ! pyrimidine dimer repair

[Term]
id: GO:0000721
name: (R,R)-butanediol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reversible reaction: (R,R)-butane-2,3-diol + NAD+ = (R)-acetoin + NADH + H(+)." [EC:1.1.1.4]
subset: gosubset_prok
synonym: "(R)-2,3-butanediol dehydrogenase activity" EXACT [EC:1.1.1.4]
synonym: "(R)-diacetyl reductase activity" EXACT [EC:1.1.1.4]
synonym: "1-amino-2-propanol dehydrogenase activity" EXACT [EC:1.1.1.4]
synonym: "1-amino-2-propanol oxidoreductase activity" EXACT [EC:1.1.1.4]
synonym: "2,3-butanediol dehydrogenase activity" EXACT [EC:1.1.1.4]
synonym: "aminopropanol oxidoreductase activity" EXACT [EC:1.1.1.4]
synonym: "butylene glycol dehydrogenase activity" EXACT [EC:1.1.1.4]
synonym: "butyleneglycol dehydrogenase activity" EXACT [EC:1.1.1.4]
synonym: "D-(-)-butanediol dehydrogenase activity" EXACT [EC:1.1.1.4]
synonym: "D-1-amino-2-propanol dehydrogenase activity" EXACT [EC:1.1.1.4]
synonym: "D-1-amino-2-propanol:NAD(2) oxidoreductase activity" EXACT [EC:1.1.1.4]
synonym: "D-aminopropanol dehydrogenase activity" EXACT [EC:1.1.1.4]
synonym: "D-butanediol dehydrogenase activity" EXACT [EC:1.1.1.4]
synonym: "diacetyl (acetoin) reductase activity" RELATED [EC:1.1.1.4]
xref: EC:1.1.1.4
xref: MetaCyc:RR-BUTANEDIOL-DEHYDROGENASE-RXN
xref: RHEA:24343
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0000722
name: telomere maintenance via recombination
namespace: biological_process
def: "Any recombinational process that contributes to the maintenance of proper telomeric length." [GOC:elh, PMID:11850777]
synonym: "telomerase-independent telomere maintenance" RELATED []
xref: Reactome:REACT_101373 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere, Xenopus tropicalis"
xref: Reactome:REACT_101439 "RFC binding displaces Pol Alpha on the C-strand of the telomere, Danio rerio"
xref: Reactome:REACT_101498 "RFC binding displaces Pol Alpha on the C-strand of the telomere, Oryza sativa"
xref: Reactome:REACT_101756 "Polymerase switching on the C-strand of the telomere, Arabidopsis thaliana"
xref: Reactome:REACT_101953 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Oryza sativa"
xref: Reactome:REACT_102170 "Polymerase switching on the C-strand of the telomere, Drosophila melanogaster"
xref: Reactome:REACT_102248 "RPA binds to the Flap on the C-strand, Danio rerio"
xref: Reactome:REACT_102860 "Polymerase switching on the C-strand of the telomere, Canis familiaris"
xref: Reactome:REACT_102881 "Removal of the Flap Intermediate from the C-strand, Oryza sativa"
xref: Reactome:REACT_103207 "Telomere C-strand synthesis initiation, Dictyostelium discoideum"
xref: Reactome:REACT_103350 "Telomere C-strand synthesis initiation, Schizosaccharomyces pombe"
xref: Reactome:REACT_103501 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Xenopus tropicalis"
xref: Reactome:REACT_103857 "Recruitment of Dna2 endonuclease to the C strand, Sus scrofa"
xref: Reactome:REACT_104171 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Danio rerio"
xref: Reactome:REACT_104453 "RFC binding displaces Pol Alpha on the C-strand of the telomere, Dictyostelium discoideum"
xref: Reactome:REACT_104638 "Polymerase switching on the C-strand of the telomere, Caenorhabditis elegans"
xref: Reactome:REACT_104914 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Rattus norvegicus"
xref: Reactome:REACT_105177 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Mus musculus"
xref: Reactome:REACT_105258 "Formation of Processive Complex on the C-strand of the telomere, Mus musculus"
xref: Reactome:REACT_105462 "Formation of C-strand Okazaki fragments, Sus scrofa"
xref: Reactome:REACT_105491 "Formation of Processive Complex on the C-strand of the telomere, Xenopus tropicalis"
xref: Reactome:REACT_106206 "Removal of the Flap Intermediate from the C-strand, Schizosaccharomyces pombe"
xref: Reactome:REACT_106874 "Polymerase switching on the C-strand of the telomere, Xenopus tropicalis"
xref: Reactome:REACT_106919 "Joining of adjacent Okazaki fragments of the C-strand, Oryza sativa"
xref: Reactome:REACT_106924 "Removal of remaining Flap from the C-strand, Bos taurus"
xref: Reactome:REACT_106994 "Formation of C-strand Okazaki fragments, Schizosaccharomyces pombe"
xref: Reactome:REACT_107163 "RFC dissociates after sliding clamp formation on the C-strand of the telomere, Dictyostelium discoideum"
xref: Reactome:REACT_107299 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere, Gallus gallus"
xref: Reactome:REACT_107682 "RFC binding displaces Pol Alpha on the C-strand of the telomere, Saccharomyces cerevisiae"
xref: Reactome:REACT_108058 "Formation of Processive Complex on the C-strand of the telomere, Oryza sativa"
xref: Reactome:REACT_108279 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Rattus norvegicus"
xref: Reactome:REACT_108285 "Processive synthesis on the C-strand of the telomere, Oryza sativa"
xref: Reactome:REACT_108323 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Plasmodium falciparum"
xref: Reactome:REACT_108876 "RFC binding displaces Pol Alpha on the C-strand of the telomere, Caenorhabditis elegans"
xref: Reactome:REACT_109084 "RFC dissociates after sliding clamp formation on the C-strand of the telomere, Bos taurus"
xref: Reactome:REACT_109593 "Formation of C-strand Okazaki fragments, Mus musculus"
xref: Reactome:REACT_109676 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere, Bos taurus"
xref: Reactome:REACT_110206 "Recruitment of Dna2 endonuclease to the C strand, Canis familiaris"
xref: Reactome:REACT_110252 "Formation of C-strand Okazaki fragments, Canis familiaris"
xref: Reactome:REACT_110586 "Removal of remaining Flap from the C-strand, Xenopus tropicalis"
xref: Reactome:REACT_110741 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Saccharomyces cerevisiae"
xref: Reactome:REACT_28103 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Schizosaccharomyces pombe"
xref: Reactome:REACT_28301 "Removal of remaining Flap from the C-strand, Danio rerio"
xref: Reactome:REACT_28337 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere, Rattus norvegicus"
xref: Reactome:REACT_28438 "RFC dissociates after sliding clamp formation on the C-strand of the telomere, Danio rerio"
xref: Reactome:REACT_28735 "Formation of the Flap Intermediate on the C-strand, Oryza sativa"
xref: Reactome:REACT_28845 "Removal of the Flap Intermediate from the C-strand, Xenopus tropicalis"
xref: Reactome:REACT_29030 "Formation of C-strand Okazaki fragments, Danio rerio"
xref: Reactome:REACT_29091 "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand, Danio rerio"
xref: Reactome:REACT_29268 "Polymerase switching on the C-strand of the telomere, Saccharomyces cerevisiae"
xref: Reactome:REACT_29498 "Joining of adjacent Okazaki fragments of the C-strand, Mus musculus"
xref: Reactome:REACT_29561 "Telomere C-strand synthesis initiation, Caenorhabditis elegans"
xref: Reactome:REACT_29730 "Processive synthesis on the C-strand of the telomere, Rattus norvegicus"
xref: Reactome:REACT_29736 "Removal of remaining Flap from the C-strand, Oryza sativa"
xref: Reactome:REACT_30132 "RFC dissociates after sliding clamp formation on the C-strand of the telomere, Arabidopsis thaliana"
xref: Reactome:REACT_30146 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere, Canis familiaris"
xref: Reactome:REACT_30357 "Recruitment of Dna2 endonuclease to the C strand, Oryza sativa"
xref: Reactome:REACT_30676 "Processive synthesis on the C-strand of the telomere, Taeniopygia guttata"
xref: Reactome:REACT_31415 "Polymerase switching on the C-strand of the telomere, Gallus gallus"
xref: Reactome:REACT_31855 "Recruitment of Dna2 endonuclease to the C strand, Xenopus tropicalis"
xref: Reactome:REACT_31896 "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand, Mus musculus"
xref: Reactome:REACT_32409 "Formation of Processive Complex on the C-strand of the telomere, Bos taurus"
xref: Reactome:REACT_32656 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere, Oryza sativa"
xref: Reactome:REACT_32714 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere, Arabidopsis thaliana"
xref: Reactome:REACT_32801 "Recruitment of Dna2 endonuclease to the C strand, Schizosaccharomyces pombe"
xref: Reactome:REACT_33015 "Formation of the Flap Intermediate on the C-strand, Sus scrofa"
xref: Reactome:REACT_33071 "Polymerase switching on the C-strand of the telomere, Bos taurus"
xref: Reactome:REACT_33514 "Recruitment of Dna2 endonuclease to the C strand, Danio rerio"
xref: Reactome:REACT_33663 "Processive synthesis on the C-strand of the telomere, Mus musculus"
xref: Reactome:REACT_33974 "Formation of the Flap Intermediate on the C-strand, Mus musculus"
xref: Reactome:REACT_34757 "Polymerase switching on the C-strand of the telomere, Taeniopygia guttata"
xref: Reactome:REACT_57279 "Processive synthesis on the C-strand of the telomere, Bos taurus"
xref: Reactome:REACT_77128 "Formation of C-strand Okazaki fragments, Oryza sativa"
xref: Reactome:REACT_77820 "Formation of Processive Complex on the C-strand of the telomere, Arabidopsis thaliana"
xref: Reactome:REACT_77906 "RFC dissociates after sliding clamp formation on the C-strand of the telomere, Plasmodium falciparum"
xref: Reactome:REACT_77925 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Plasmodium falciparum"
xref: Reactome:REACT_78056 "Formation of the Flap Intermediate on the C-strand, Rattus norvegicus"
xref: Reactome:REACT_78182 "Telomere C-strand synthesis initiation, Rattus norvegicus"
xref: Reactome:REACT_78501 "Formation of the Flap Intermediate on the C-strand, Bos taurus"
xref: Reactome:REACT_78969 "Joining of adjacent Okazaki fragments of the C-strand, Bos taurus"
xref: Reactome:REACT_79008 "Recruitment of Dna2 endonuclease to the C strand, Arabidopsis thaliana"
xref: Reactome:REACT_79101 "Removal of the Flap Intermediate from the C-strand, Danio rerio"
xref: Reactome:REACT_7949 "RPA binds to the Flap on the C-strand, Homo sapiens"
xref: Reactome:REACT_7955 "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand, Homo sapiens"
xref: Reactome:REACT_7967 "RFC dissociates after sliding clamp formation on the C-strand of the telomere, Homo sapiens"
xref: Reactome:REACT_7973 "Formation of the Flap Intermediate on the C-strand, Homo sapiens"
xref: Reactome:REACT_7975 "Removal of remaining Flap from the C-strand, Homo sapiens"
xref: Reactome:REACT_7979 "Formation of Processive Complex on the C-strand of the telomere, Homo sapiens"
xref: Reactome:REACT_7987 "Polymerase switching on the C-strand of the telomere, Homo sapiens"
xref: Reactome:REACT_7993 "Telomere C-strand synthesis initiation, Homo sapiens"
xref: Reactome:REACT_7994 "Joining of adjacent Okazaki fragments of the C-strand, Homo sapiens"
xref: Reactome:REACT_79977 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Saccharomyces cerevisiae"
xref: Reactome:REACT_7998 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Homo sapiens"
xref: Reactome:REACT_7999 "Removal of the Flap Intermediate from the C-strand, Homo sapiens"
xref: Reactome:REACT_8000 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere, Homo sapiens"
xref: Reactome:REACT_8004 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Homo sapiens"
xref: Reactome:REACT_8008 "RFC binding displaces Pol Alpha on the C-strand of the telomere, Homo sapiens"
xref: Reactome:REACT_8015 "Recruitment of Dna2 endonuclease to the C strand, Homo sapiens"
xref: Reactome:REACT_80165 "Removal of the Flap Intermediate from the C-strand, Taeniopygia guttata"
xref: Reactome:REACT_8027 "Processive synthesis on the C-strand of the telomere, Homo sapiens"
xref: Reactome:REACT_8029 "Formation of C-strand Okazaki fragments, Homo sapiens"
xref: Reactome:REACT_80513 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Dictyostelium discoideum"
xref: Reactome:REACT_80567 "Polymerase switching on the C-strand of the telomere, Mus musculus"
xref: Reactome:REACT_80653 "Telomere C-strand synthesis initiation, Sus scrofa"
xref: Reactome:REACT_80757 "RFC dissociates after sliding clamp formation on the C-strand of the telomere, Saccharomyces cerevisiae"
xref: Reactome:REACT_80999 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Schizosaccharomyces pombe"
xref: Reactome:REACT_81201 "Removal of remaining Flap from the C-strand, Mus musculus"
xref: Reactome:REACT_81258 "RFC binding displaces Pol Alpha on the C-strand of the telomere, Schizosaccharomyces pombe"
xref: Reactome:REACT_81387 "Formation of Processive Complex on the C-strand of the telomere, Rattus norvegicus"
xref: Reactome:REACT_81697 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere, Taeniopygia guttata"
xref: Reactome:REACT_81968 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Sus scrofa"
xref: Reactome:REACT_81990 "Joining of adjacent Okazaki fragments of the C-strand, Danio rerio"
xref: Reactome:REACT_82014 "RFC dissociates after sliding clamp formation on the C-strand of the telomere, Caenorhabditis elegans"
xref: Reactome:REACT_82097 "Processive synthesis on the C-strand of the telomere, Schizosaccharomyces pombe"
xref: Reactome:REACT_82246 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Drosophila melanogaster"
xref: Reactome:REACT_82465 "Processive synthesis on the C-strand of the telomere, Arabidopsis thaliana"
xref: Reactome:REACT_82605 "Telomere C-strand synthesis initiation, Canis familiaris"
xref: Reactome:REACT_82834 "RFC dissociates after sliding clamp formation on the C-strand of the telomere, Canis familiaris"
xref: Reactome:REACT_83118 "RFC binding displaces Pol Alpha on the C-strand of the telomere, Plasmodium falciparum"
xref: Reactome:REACT_83299 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere, Danio rerio"
xref: Reactome:REACT_83482 "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand, Xenopus tropicalis"
xref: Reactome:REACT_83617 "RFC dissociates after sliding clamp formation on the C-strand of the telomere, Oryza sativa"
xref: Reactome:REACT_83805 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Drosophila melanogaster"
xref: Reactome:REACT_84276 "Recruitment of Dna2 endonuclease to the C strand, Taeniopygia guttata"
xref: Reactome:REACT_84292 "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand, Bos taurus"
xref: Reactome:REACT_84527 "Joining of adjacent Okazaki fragments of the C-strand, Xenopus tropicalis"
xref: Reactome:REACT_84864 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Mus musculus"
xref: Reactome:REACT_85303 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Arabidopsis thaliana"
xref: Reactome:REACT_85614 "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand, Rattus norvegicus"
xref: Reactome:REACT_85781 "Joining of adjacent Okazaki fragments of the C-strand, Schizosaccharomyces pombe"
xref: Reactome:REACT_85910 "Joining of adjacent Okazaki fragments of the C-strand, Canis familiaris"
xref: Reactome:REACT_85945 "RFC binding displaces Pol Alpha on the C-strand of the telomere, Xenopus tropicalis"
xref: Reactome:REACT_86438 "Removal of the Flap Intermediate from the C-strand, Mus musculus"
xref: Reactome:REACT_86551 "Formation of the Flap Intermediate on the C-strand, Danio rerio"
xref: Reactome:REACT_86566 "RPA binds to the Flap on the C-strand, Mus musculus"
xref: Reactome:REACT_86673 "Processive synthesis on the C-strand of the telomere, Xenopus tropicalis"
xref: Reactome:REACT_86894 "RFC binding displaces Pol Alpha on the C-strand of the telomere, Bos taurus"
xref: Reactome:REACT_87128 "Processive synthesis on the C-strand of the telomere, Canis familiaris"
xref: Reactome:REACT_87148 "Recruitment of Dna2 endonuclease to the C strand, Rattus norvegicus"
xref: Reactome:REACT_87271 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Xenopus tropicalis"
xref: Reactome:REACT_87564 "Recruitment of Dna2 endonuclease to the C strand, Mus musculus"
xref: Reactome:REACT_87776 "Removal of the Flap Intermediate from the C-strand, Canis familiaris"
xref: Reactome:REACT_87852 "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand, Canis familiaris"
xref: Reactome:REACT_87982 "Removal of the Flap Intermediate from the C-strand, Arabidopsis thaliana"
xref: Reactome:REACT_88080 "Telomere C-strand synthesis initiation, Mus musculus"
xref: Reactome:REACT_88200 "Formation of the Flap Intermediate on the C-strand, Canis familiaris"
xref: Reactome:REACT_88586 "RPA binds to the Flap on the C-strand, Rattus norvegicus"
xref: Reactome:REACT_88760 "Removal of remaining Flap from the C-strand, Sus scrofa"
xref: Reactome:REACT_88793 "RPA binds to the Flap on the C-strand, Bos taurus"
xref: Reactome:REACT_88811 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Danio rerio"
xref: Reactome:REACT_89109 "RFC binding displaces Pol Alpha on the C-strand of the telomere, Canis familiaris"
xref: Reactome:REACT_89136 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere, Schizosaccharomyces pombe"
xref: Reactome:REACT_89422 "RPA binds to the Flap on the C-strand, Xenopus tropicalis"
xref: Reactome:REACT_89618 "Joining of adjacent Okazaki fragments of the C-strand, Rattus norvegicus"
xref: Reactome:REACT_89731 "Polymerase switching on the C-strand of the telomere, Rattus norvegicus"
xref: Reactome:REACT_89859 "Polymerase switching on the C-strand of the telomere, Danio rerio"
xref: Reactome:REACT_89896 "Formation of C-strand Okazaki fragments, Bos taurus"
xref: Reactome:REACT_90432 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Caenorhabditis elegans"
xref: Reactome:REACT_90507 "Polymerase switching on the C-strand of the telomere, Schizosaccharomyces pombe"
xref: Reactome:REACT_90656 "RFC dissociates after sliding clamp formation on the C-strand of the telomere, Rattus norvegicus"
xref: Reactome:REACT_91124 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Caenorhabditis elegans"
xref: Reactome:REACT_91185 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Bos taurus"
xref: Reactome:REACT_91218 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Oryza sativa"
xref: Reactome:REACT_91365 "Formation of C-strand Okazaki fragments, Rattus norvegicus"
xref: Reactome:REACT_91568 "Recruitment of Dna2 endonuclease to the C strand, Bos taurus"
xref: Reactome:REACT_91624 "Telomere C-strand synthesis initiation, Saccharomyces cerevisiae"
xref: Reactome:REACT_91633 "RFC dissociates after sliding clamp formation on the C-strand of the telomere, Gallus gallus"
xref: Reactome:REACT_91661 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere, Caenorhabditis elegans"
xref: Reactome:REACT_92017 "Telomere C-strand synthesis initiation, Arabidopsis thaliana"
xref: Reactome:REACT_92092 "Joining of adjacent Okazaki fragments of the C-strand, Sus scrofa"
xref: Reactome:REACT_92189 "Processive synthesis on the C-strand of the telomere, Danio rerio"
xref: Reactome:REACT_92339 "Removal of remaining Flap from the C-strand, Rattus norvegicus"
xref: Reactome:REACT_92420 "RFC binding displaces Pol Alpha on the C-strand of the telomere, Sus scrofa"
xref: Reactome:REACT_92505 "Removal of the Flap Intermediate from the C-strand, Rattus norvegicus"
xref: Reactome:REACT_92773 "Formation of Processive Complex on the C-strand of the telomere, Schizosaccharomyces pombe"
xref: Reactome:REACT_93121 "Polymerase switching on the C-strand of the telomere, Sus scrofa"
xref: Reactome:REACT_93535 "Formation of C-strand Okazaki fragments, Arabidopsis thaliana"
xref: Reactome:REACT_93603 "RFC dissociates after sliding clamp formation on the C-strand of the telomere, Taeniopygia guttata"
xref: Reactome:REACT_93674 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Dictyostelium discoideum"
xref: Reactome:REACT_93682 "RFC binding displaces Pol Alpha on the C-strand of the telomere, Arabidopsis thaliana"
xref: Reactome:REACT_93745 "RFC dissociates after sliding clamp formation on the C-strand of the telomere, Schizosaccharomyces pombe"
xref: Reactome:REACT_93828 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Canis familiaris"
xref: Reactome:REACT_93893 "Removal of the Flap Intermediate from the C-strand, Bos taurus"
xref: Reactome:REACT_94317 "Joining of adjacent Okazaki fragments of the C-strand, Arabidopsis thaliana"
xref: Reactome:REACT_94323 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Canis familiaris"
xref: Reactome:REACT_94685 "RFC dissociates after sliding clamp formation on the C-strand of the telomere, Xenopus tropicalis"
xref: Reactome:REACT_94878 "Formation of the Flap Intermediate on the C-strand, Xenopus tropicalis"
xref: Reactome:REACT_94930 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere, Drosophila melanogaster"
xref: Reactome:REACT_95256 "Polymerase switching on the C-strand of the telomere, Dictyostelium discoideum"
xref: Reactome:REACT_95355 "Polymerase switching on the C-strand of the telomere, Oryza sativa"
xref: Reactome:REACT_95570 "RPA binds to the Flap on the C-strand, Canis familiaris"
xref: Reactome:REACT_95593 "Telomere C-strand synthesis initiation, Bos taurus"
xref: Reactome:REACT_95767 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere, Plasmodium falciparum"
xref: Reactome:REACT_95954 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere, Mus musculus"
xref: Reactome:REACT_96276 "Removal of remaining Flap from the C-strand, Schizosaccharomyces pombe"
xref: Reactome:REACT_96429 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Arabidopsis thaliana"
xref: Reactome:REACT_96454 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere, Saccharomyces cerevisiae"
xref: Reactome:REACT_96676 "RFC binding displaces Pol Alpha on the C-strand of the telomere, Mus musculus"
xref: Reactome:REACT_96810 "RFC dissociates after sliding clamp formation on the C-strand of the telomere, Drosophila melanogaster"
xref: Reactome:REACT_97064 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Bos taurus"
xref: Reactome:REACT_97146 "Removal of remaining Flap from the C-strand, Arabidopsis thaliana"
xref: Reactome:REACT_97211 "Telomere C-strand synthesis initiation, Drosophila melanogaster"
xref: Reactome:REACT_97260 "Formation of C-strand Okazaki fragments, Xenopus tropicalis"
xref: Reactome:REACT_97574 "Formation of the Flap Intermediate on the C-strand, Arabidopsis thaliana"
xref: Reactome:REACT_97781 "Telomere C-strand synthesis initiation, Danio rerio"
xref: Reactome:REACT_97849 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere, Dictyostelium discoideum"
xref: Reactome:REACT_98163 "RFC dissociates after sliding clamp formation on the C-strand of the telomere, Mus musculus"
xref: Reactome:REACT_98508 "Telomere C-strand synthesis initiation, Oryza sativa"
xref: Reactome:REACT_98514 "Telomere C-strand synthesis initiation, Xenopus tropicalis"
xref: Reactome:REACT_98606 "Formation of Processive Complex on the C-strand of the telomere, Danio rerio"
xref: Reactome:REACT_98653 "RFC binding displaces Pol Alpha on the C-strand of the telomere, Drosophila melanogaster"
xref: Reactome:REACT_98674 "Formation of Processive Complex on the C-strand of the telomere, Canis familiaris"
xref: Reactome:REACT_98759 "RFC binding displaces Pol Alpha on the C-strand of the telomere, Rattus norvegicus"
xref: Reactome:REACT_98885 "Formation of the Flap Intermediate on the C-strand, Schizosaccharomyces pombe"
xref: Reactome:REACT_99121 "Removal of the Flap Intermediate from the C-strand, Sus scrofa"
xref: Reactome:REACT_99658 "Processive synthesis on the C-strand of the telomere, Sus scrofa"
xref: Reactome:REACT_99801 "Polymerase switching on the C-strand of the telomere, Plasmodium falciparum"
xref: Reactome:REACT_99836 "Telomere C-strand synthesis initiation, Plasmodium falciparum"
is_a: GO:0000723 ! telomere maintenance
is_a: GO:0006312 ! mitotic recombination

[Term]
id: GO:0000723
name: telomere maintenance
namespace: biological_process
def: "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831]
synonym: "regulation of telomere length" RELATED [GOC:dph, GOC:tb]
xref: Reactome:REACT_102051 "Telomere Maintenance, Sus scrofa"
xref: Reactome:REACT_102166 "Telomere Maintenance, Schizosaccharomyces pombe"
xref: Reactome:REACT_103257 "Telomere Maintenance, Bos taurus"
xref: Reactome:REACT_103618 "Telomere Maintenance, Canis familiaris"
xref: Reactome:REACT_104398 "Telomere Maintenance, Dictyostelium discoideum"
xref: Reactome:REACT_105276 "Disassociation of Processive Complex and Completed Telomere End, Canis familiaris"
xref: Reactome:REACT_105401 "Packaging Of Telomere Ends, Rattus norvegicus"
xref: Reactome:REACT_105641 "Disassociation of Processive Complex and Completed Telomere End, Mus musculus"
xref: Reactome:REACT_107344 "Disassociation of Processive Complex and Completed Telomere End, Xenopus tropicalis"
xref: Reactome:REACT_109055 "Disassociation of Processive Complex and Completed Telomere End, Schizosaccharomyces pombe"
xref: Reactome:REACT_110319 "Telomere Maintenance, Rattus norvegicus"
xref: Reactome:REACT_115102 "Packaging Of Telomere Ends, Canis familiaris"
xref: Reactome:REACT_115503 "Packaging Of Telomere Ends, Danio rerio"
xref: Reactome:REACT_115535 "Telomere maintenance, Gallus gallus"
xref: Reactome:REACT_31996 "Disassociation of Processive Complex and Completed Telomere End, Rattus norvegicus"
xref: Reactome:REACT_32322 "Packaging Of Telomere Ends, Sus scrofa"
xref: Reactome:REACT_78001 "Telomere Maintenance, Danio rerio"
xref: Reactome:REACT_78680 "Telomere Maintenance, Saccharomyces cerevisiae"
xref: Reactome:REACT_7954 "Disassociation of Processive Complex and Completed Telomere End, Homo sapiens"
xref: Reactome:REACT_7963 "Packaging Of Telomere Ends, Homo sapiens"
xref: Reactome:REACT_7970 "Telomere Maintenance, Homo sapiens"
xref: Reactome:REACT_80940 "Telomere Maintenance, Plasmodium falciparum"
xref: Reactome:REACT_82431 "Disassociation of Processive Complex and Completed Telomere End, Danio rerio"
xref: Reactome:REACT_83277 "Disassociation of Processive Complex and Completed Telomere End, Bos taurus"
xref: Reactome:REACT_84888 "Telomere Maintenance, Mus musculus"
xref: Reactome:REACT_85317 "Disassociation of Processive Complex and Completed Telomere End, Oryza sativa"
xref: Reactome:REACT_85782 "Telomere Maintenance, Arabidopsis thaliana"
xref: Reactome:REACT_86038 "Telomere Maintenance, Drosophila melanogaster"
xref: Reactome:REACT_86194 "Disassociation of Processive Complex and Completed Telomere End, Arabidopsis thaliana"
xref: Reactome:REACT_87184 "Telomere Maintenance, Caenorhabditis elegans"
xref: Reactome:REACT_88530 "Packaging Of Telomere Ends, Mus musculus"
xref: Reactome:REACT_94176 "Telomere Maintenance, Gallus gallus"
xref: Reactome:REACT_94707 "Telomere Maintenance, Oryza sativa"
xref: Reactome:REACT_96013 "Telomere Maintenance, Taeniopygia guttata"
xref: Reactome:REACT_96166 "Telomere Maintenance, Xenopus tropicalis"
is_a: GO:0006259 ! DNA metabolic process
is_a: GO:0032200 ! telomere organization
is_a: GO:0044710 ! single-organism metabolic process
is_a: GO:0060249 ! anatomical structure homeostasis
is_a: GO:1902589 ! single-organism organelle organization

[Term]
id: GO:0000724
name: double-strand break repair via homologous recombination
namespace: biological_process
alt_id: GO:0016924
def: "The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855]
subset: gosubset_prok
synonym: "HDR" EXACT [GOC:vk]
synonym: "homologous recombinational repair" EXACT []
synonym: "homology-directed repair" EXACT [GOC:vk]
synonym: "HRR" EXACT []
synonym: "Rad51-dependent recombinational repair" EXACT [GOC:mah]
synonym: "Rhp51-dependent recombinational repair" EXACT []
xref: Reactome:REACT_103005 "Homologous Recombination Repair, Caenorhabditis elegans"
xref: Reactome:REACT_108237 "Homologous Recombination Repair, Saccharomyces cerevisiae"
xref: Reactome:REACT_115539 "Recruitment of repair and signaling proteins to double-strand breaks, Gallus gallus"
xref: Reactome:REACT_115585 "Homologous recombination repair of replication-dependent double-strand breaks, Gallus gallus"
xref: Reactome:REACT_115626 "Homologous DNA pairing and strand exchange, Gallus gallus"
xref: Reactome:REACT_115651 "ATM mediated response to DNA double-strand break, Gallus gallus"
xref: Reactome:REACT_115715 "ATM mediated phosphorylation of repair proteins, Gallus gallus"
xref: Reactome:REACT_115769 "Homologous recombination repair, Gallus gallus"
xref: Reactome:REACT_115931 "Processing of DNA double-strand break ends, Gallus gallus"
xref: Reactome:REACT_115936 "Homologous recombination repair (HRR) of replication-independent double-strand breaks, Gallus gallus"
xref: Reactome:REACT_1874 "Homologous Recombination Repair, Homo sapiens"
xref: Reactome:REACT_29815 "Homologous Recombination Repair, Sus scrofa"
xref: Reactome:REACT_33853 "Homologous Recombination Repair, Oryza sativa"
xref: Reactome:REACT_42307 "Homologous Recombination Repair, Gallus gallus"
xref: Reactome:REACT_80576 "Homologous Recombination Repair, Schizosaccharomyces pombe"
xref: Reactome:REACT_82771 "Homologous Recombination Repair, Xenopus tropicalis"
xref: Reactome:REACT_83941 "Homologous Recombination Repair, Plasmodium falciparum"
xref: Reactome:REACT_84594 "Homologous Recombination Repair, Dictyostelium discoideum"
xref: Reactome:REACT_84793 "Homologous Recombination Repair, Danio rerio"
xref: Reactome:REACT_85965 "Homologous Recombination Repair, Drosophila melanogaster"
xref: Reactome:REACT_87979 "Homologous Recombination Repair, Mycobacterium tuberculosis"
xref: Reactome:REACT_90944 "Homologous Recombination Repair, Mus musculus"
xref: Reactome:REACT_92384 "Homologous Recombination Repair, Canis familiaris"
xref: Reactome:REACT_92897 "Homologous Recombination Repair, Arabidopsis thaliana"
xref: Reactome:REACT_97339 "Homologous Recombination Repair, Taeniopygia guttata"
xref: Reactome:REACT_99066 "Homologous Recombination Repair, Rattus norvegicus"
xref: Reactome:REACT_99423 "Homologous Recombination Repair, Bos taurus"
is_a: GO:0000725 ! recombinational repair
is_a: GO:0006302 ! double-strand break repair

[Term]
id: GO:0000725
name: recombinational repair
namespace: biological_process
def: "A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous region of DNA." [GOC:elh]
subset: gosubset_prok
xref: Wikipedia:Recombinational_repair
is_a: GO:0006281 ! DNA repair
is_a: GO:0006310 ! DNA recombination

[Term]
id: GO:0000726
name: non-recombinational repair
namespace: biological_process
def: "A DNA repair process in which that does not require the exchange of genetic material between the broken DNA molecule and a homologous region of DNA." [GOC:elh]
subset: gosubset_prok
is_a: GO:0006281 ! DNA repair

[Term]
id: GO:0000727
name: double-strand break repair via break-induced replication
namespace: biological_process
def: "The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome." [GOC:elh, PMID:10357855]
subset: gosubset_prok
is_a: GO:0000724 ! double-strand break repair via homologous recombination

[Term]
id: GO:0000728
name: gene conversion at mating-type locus, DNA double-strand break formation
namespace: biological_process
def: "The site-specific endonucleolytic cleavage of DNA at the mating-type locus which initiates the conversion of one mating-type allele to another." [GOC:elh, PMID:7646483]
is_a: GO:0022414 ! reproductive process
is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis
relationship: part_of GO:0007534 ! gene conversion at mating-type locus

[Term]
id: GO:0000729
name: DNA double-strand break processing
namespace: biological_process
def: "The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang." [PMID:10357855]
xref: Reactome:REACT_172 "Resection of double-strand break ends, Homo sapiens"
is_a: GO:0006259 ! DNA metabolic process
relationship: has_part GO:0035312 ! 5'-3' exodeoxyribonuclease activity
relationship: part_of GO:0006302 ! double-strand break repair

[Term]
id: GO:0000730
name: DNA recombinase assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of strand exchange proteins (recombinases) into higher order oligomers on single-stranded DNA." [PMID:10357855]
synonym: "Rad51 nucleoprotein filament formation" EXACT [GOC:elh, GOC:vw]
xref: Reactome:REACT_100225 "Assembly of the RAD51-ssDNA nucleoprotein complex, Gallus gallus"
xref: Reactome:REACT_100616 "Assembly of the RAD51-ssDNA nucleoprotein complex, Plasmodium falciparum"
xref: Reactome:REACT_101062 "Assembly of the RAD51-ssDNA nucleoprotein complex, Arabidopsis thaliana"
xref: Reactome:REACT_102016 "Assembly of the RAD51-ssDNA nucleoprotein complex, Dictyostelium discoideum"
xref: Reactome:REACT_103788 "Assembly of the RAD51-ssDNA nucleoprotein complex, Drosophila melanogaster"
xref: Reactome:REACT_104366 "Assembly of the RAD51-ssDNA nucleoprotein complex, Schizosaccharomyces pombe"
xref: Reactome:REACT_106498 "Assembly of the RAD51-ssDNA nucleoprotein complex, Taeniopygia guttata"
xref: Reactome:REACT_110494 "Assembly of the RAD51-ssDNA nucleoprotein complex, Mus musculus"
xref: Reactome:REACT_2141 "Assembly of the RAD51-ssDNA nucleoprotein complex, Homo sapiens"
xref: Reactome:REACT_28107 "Assembly of the RAD51-ssDNA nucleoprotein complex, Saccharomyces cerevisiae"
xref: Reactome:REACT_32257 "Assembly of the RAD51-ssDNA nucleoprotein complex, Bos taurus"
xref: Reactome:REACT_78586 "Assembly of the RAD51-ssDNA nucleoprotein complex, Canis familiaris"
xref: Reactome:REACT_79561 "Assembly of the RAD51-ssDNA nucleoprotein complex, Sus scrofa"
xref: Reactome:REACT_81810 "Assembly of the RAD51-ssDNA nucleoprotein complex, Xenopus tropicalis"
xref: Reactome:REACT_82066 "Assembly of the RAD51-ssDNA nucleoprotein complex, Caenorhabditis elegans"
xref: Reactome:REACT_85201 "Assembly of the RAD51-ssDNA nucleoprotein complex, Oryza sativa"
xref: Reactome:REACT_88197 "Assembly of the RAD51-ssDNA nucleoprotein complex, Rattus norvegicus"
xref: Reactome:REACT_96901 "Assembly of the RAD51-ssDNA nucleoprotein complex, Danio rerio"
is_a: GO:0065004 ! protein-DNA complex assembly
relationship: part_of GO:0045003 ! double-strand break repair via synthesis-dependent strand annealing

[Term]
id: GO:0000731
name: DNA synthesis involved in DNA repair
namespace: biological_process
def: "Synthesis of DNA that proceeds from the broken 3' single-strand DNA end and uses the homologous intact duplex as the template." [PMID:10357855]
subset: gosubset_prok
synonym: "DNA repair synthesis" BROAD []
synonym: "DNA synthesis during DNA repair" RELATED [GOC:dph, GOC:tb]
synonym: "mitotic DNA repair synthesis" NARROW [GOC:mah]
xref: Reactome:REACT_973 "DNA repair synthesis, Homo sapiens"
is_a: GO:0071897 ! DNA biosynthetic process
intersection_of: GO:0071897 ! DNA biosynthetic process
intersection_of: part_of GO:0006281 ! DNA repair
relationship: part_of GO:0006281 ! DNA repair

[Term]
id: GO:0000732
name: strand displacement
namespace: biological_process
def: "The rejection of the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules." [PMID:10357855]
subset: gosubset_prok
synonym: "D-loop dissociation" RELATED [GOC:mah, GOC:vw]
synonym: "D-loop processing" RELATED [GOC:mah, GOC:vw]
synonym: "displacement loop dissociation" RELATED [GOC:mah, GOC:vw]
synonym: "displacement loop processing" RELATED [GOC:mah, GOC:vw]
xref: Reactome:REACT_287 "Dissociation of the extended strands, Homo sapiens"
is_a: GO:0006259 ! DNA metabolic process
relationship: part_of GO:0006310 ! DNA recombination

[Term]
id: GO:0000733
name: DNA strand renaturation
namespace: biological_process
def: "The identification and annealing of complementary base pairs in single-strand DNA." [GOC:elh]
subset: gosubset_prok
is_a: GO:0006259 ! DNA metabolic process

[Term]
id: GO:0000734
name: gene conversion at mating-type locus, DNA repair synthesis
namespace: biological_process
def: "Synthesis of DNA that proceeds from the broken 3' single-strand DNA end uses the homologous intact duplex as the template during gene conversion at the mating-type locus." [GOC:elh]
is_a: GO:0000731 ! DNA synthesis involved in DNA repair
is_a: GO:0022414 ! reproductive process
intersection_of: GO:0000731 ! DNA synthesis involved in DNA repair
intersection_of: part_of GO:0007534 ! gene conversion at mating-type locus
relationship: part_of GO:0007534 ! gene conversion at mating-type locus

[Term]
id: GO:0000735
name: removal of nonhomologous ends
namespace: biological_process
def: "The removal of nonhomologous sequences at the broken 3' single-strand DNA end before DNA repair synthesis can occur." [PMID:10357855]
is_a: GO:0006259 ! DNA metabolic process
relationship: has_part GO:0004520 ! endodeoxyribonuclease activity

[Term]
id: GO:0000736
name: double-strand break repair via single-strand annealing, removal of nonhomologous ends
namespace: biological_process
def: "During DSBR via single-strand annealing, the removal of nonhomologous sequences at the broken 3' single-strand DNA end before DNA repair synthesis can occur." [PMID:10357855]
subset: gosubset_prok
is_a: GO:0000735 ! removal of nonhomologous ends
intersection_of: GO:0000735 ! removal of nonhomologous ends
intersection_of: part_of GO:0045002 ! double-strand break repair via single-strand annealing
relationship: part_of GO:0045002 ! double-strand break repair via single-strand annealing

[Term]
id: GO:0000737
name: DNA catabolic process, endonucleolytic
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides." [GOC:elh, GOC:mah]
subset: gosubset_prok
synonym: "DNA breakdown, endonucleolytic" EXACT []
synonym: "DNA degradation, endonucleolytic" EXACT []
synonym: "endonucleolytic degradation of DNA" EXACT []
synonym: "endonucleolytic DNA catabolism" EXACT []
is_a: GO:0006308 ! DNA catabolic process
is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis
relationship: has_part GO:0004520 ! endodeoxyribonuclease activity

[Term]
id: GO:0000738
name: DNA catabolic process, exonucleolytic
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides." [GOC:elh, GOC:mah]
subset: gosubset_prok
synonym: "DNA breakdown, exonucleolytic" EXACT []
synonym: "DNA degradation, exonucleolytic" EXACT []
synonym: "exonucleolytic degradation of DNA" EXACT []
is_a: GO:0006308 ! DNA catabolic process
is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis
relationship: has_part GO:0004529 ! exodeoxyribonuclease activity

[Term]
id: GO:0000739
name: obsolete DNA strand annealing activity
namespace: molecular_function
def: "OBSOLETE. Facilitates the base-pairing of complementary single-stranded DNA." [GOC:elh]
comment: This term was made obsolete because it describes a process and not an activity.
synonym: "DNA strand annealing activity" EXACT []
is_obsolete: true
consider: GO:0000733
consider: GO:0036292
consider: GO:0036310

[Term]
id: GO:0000740
name: nuclear membrane fusion
namespace: biological_process
def: "The joining of 2 or more lipid bilayer membranes that surround the nucleus." [GOC:elh]
is_a: GO:0000741 ! karyogamy
is_a: GO:0090174 ! organelle membrane fusion

[Term]
id: GO:0000741
name: karyogamy
namespace: biological_process
alt_id: GO:0007335
def: "The creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei." [GOC:elh]
synonym: "nuclear fusion" EXACT []
synonym: "nuclear fusion during karyogamy" EXACT []
xref: Wikipedia:Karyogamy
is_a: GO:0048284 ! organelle fusion
relationship: part_of GO:0006997 ! nucleus organization

[Term]
id: GO:0000742
name: karyogamy involved in conjugation with cellular fusion
namespace: biological_process
def: "During sexual reproduction, the creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei. This occurs after cytogamy." [GOC:elh]
synonym: "karyogamy during conjugation with cellular fusion" RELATED [GOC:dph, GOC:tb]
is_a: GO:0000741 ! karyogamy
is_a: GO:0022414 ! reproductive process
intersection_of: GO:0000741 ! karyogamy
intersection_of: part_of GO:0000747 ! conjugation with cellular fusion
relationship: part_of GO:0000747 ! conjugation with cellular fusion

[Term]
id: GO:0000743
name: nuclear migration involved in conjugation with cellular fusion
namespace: biological_process
alt_id: GO:0006946
def: "The microtubule-based movement of nuclei towards one another as a prelude to karyogamy in organisms undergoing conjugation with cellular fusion." [GOC:clt, GOC:vw, PMID:16380440]
synonym: "nuclear congression" EXACT [GOC:vw]
synonym: "nuclear migration during conjugation with cellular fusion" RELATED [GOC:dph, GOC:tb]
is_a: GO:0030473 ! nuclear migration along microtubule
is_a: GO:0044702 ! single organism reproductive process
intersection_of: GO:0007097 ! nuclear migration
intersection_of: part_of GO:0000747 ! conjugation with cellular fusion
relationship: part_of GO:0000747 ! conjugation with cellular fusion

[Term]
id: GO:0000744
name: karyogamy involved in conjugation with mutual genetic exchange
namespace: biological_process
def: "During sexual reproduction, the creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei. This occurs after the mutual exchange of nuclei." [GOC:elh]
synonym: "karyogamy involved in conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb]
is_a: GO:0000741 ! karyogamy
intersection_of: GO:0000741 ! karyogamy
intersection_of: part_of GO:0000748 ! conjugation with mutual genetic exchange
relationship: part_of GO:0000748 ! conjugation with mutual genetic exchange

[Term]
id: GO:0000745
name: nuclear migration involved in conjugation with mutual genetic exchange
namespace: biological_process
def: "The net movement of nuclei towards one another, leading to the bilateral transfer of genetic material in organisms undergoing conjugation without cellular fusion." [GOC:clt, GOC:mah]
synonym: "nuclear exchange during conjugation without cellular fusion" RELATED []
synonym: "nuclear migration involved in conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb]
is_a: GO:0007097 ! nuclear migration
intersection_of: GO:0007097 ! nuclear migration
intersection_of: part_of GO:0000748 ! conjugation with mutual genetic exchange
relationship: part_of GO:0000744 ! karyogamy involved in conjugation with mutual genetic exchange
relationship: part_of GO:0000748 ! conjugation with mutual genetic exchange

[Term]
id: GO:0000746
name: conjugation
namespace: biological_process
def: "The union or introduction of genetic information from compatible mating types that results in a genetically different individual. Conjugation requires direct cellular contact between the organisms." [GOC:elh]
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
xref: Wikipedia:Conjugation
is_a: GO:0044764 ! multi-organism cellular process

[Term]
id: GO:0000747
name: conjugation with cellular fusion
namespace: biological_process
alt_id: GO:0007322
alt_id: GO:0007333
alt_id: GO:0030461
alt_id: GO:0030477
def: "A conjugation process that results in the union of cellular and genetic information from compatible mating types. An example of this process is found in Saccharomyces cerevisiae." [GOC:elh]
subset: goslim_pombe
synonym: "cell fusion" RELATED []
synonym: "mating" RELATED []
is_a: GO:0000746 ! conjugation
is_a: GO:0019953 ! sexual reproduction

[Term]
id: GO:0000748
name: conjugation with mutual genetic exchange
namespace: biological_process
def: "A conjugation process that results in the mutual exchange and union of only genetic information between compatible mating types. Conjugation without cellular fusion requires direct cellular contact between the organisms without plasma membrane fusion. The organisms involved in conjugation without cellular fusion separate after nuclear exchange." [GOC:elh]
synonym: "conjugation without cellular fusion" EXACT []
is_a: GO:0000746 ! conjugation

[Term]
id: GO:0000749
name: response to pheromone involved in conjugation with cellular fusion
namespace: biological_process
alt_id: GO:0007328
alt_id: GO:0030434
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus that contributes to the process of conjugation with cellular fusion. An example of this process is found in Saccharomyces cerevisiae." [GOC:clt]
synonym: "response to pheromone during conjugation with cellular fusion" RELATED [GOC:dph]
is_a: GO:0022414 ! reproductive process
is_a: GO:0071444 ! cellular response to pheromone
intersection_of: GO:0019236 ! response to pheromone
intersection_of: part_of GO:0000747 ! conjugation with cellular fusion
relationship: part_of GO:0000747 ! conjugation with cellular fusion

[Term]
id: GO:0000750
name: pheromone-dependent signal transduction involved in conjugation with cellular fusion
namespace: biological_process
alt_id: GO:0007330
alt_id: GO:0030454
def: "A signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion. An example of this process is found in Saccharomyces cerevisiae." [GOC:clt]
synonym: "transduction of mating signal" BROAD []
is_a: GO:0007186 ! G-protein coupled receptor signaling pathway
is_a: GO:0032005 ! signal transduction involved in conjugation with cellular fusion
relationship: part_of GO:0000749 ! response to pheromone involved in conjugation with cellular fusion

[Term]
id: GO:0000751
name: mitotic cell cycle arrest in response to pheromone
namespace: biological_process
alt_id: GO:0030571
def: "The cell cycle regulatory process in which the mitotic cell cycle is halted during one of the normal phases (G1, S, G2, M) as a result of a pheromone stimulus. An example of this process is found in Saccharomyces cerevisiae." [GOC:clt, GOC:dph, GOC:mah, GOC:tb]
synonym: "cell cycle arrest in response to pheromone" BROAD []
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0071850 ! mitotic cell cycle arrest
relationship: part_of GO:0000749 ! response to pheromone involved in conjugation with cellular fusion

[Term]
id: GO:0000752
name: agglutination involved in conjugation with cellular fusion
namespace: biological_process
alt_id: GO:0007334
def: "During conjugation with cellular fusion, the aggregation or adhesion of compatible mating types via complementary cell-cell interactions. An example of this process is agglutination in Saccharomyces cerevisiae." [GOC:elh]
synonym: "agglutination" BROAD []
synonym: "cell-cell adhesion during conjugation with cellular fusion" EXACT []
synonym: "cell-cell adhesion during mating" EXACT []
is_a: GO:0000771 ! agglutination involved in conjugation
is_a: GO:0044703 ! multi-organism reproductive process
is_a: GO:0098630 ! aggregation of unicellular organisms
intersection_of: GO:0098610 ! adhesion between unicellular organisms
intersection_of: part_of GO:0000747 ! conjugation with cellular fusion
relationship: part_of GO:0000747 ! conjugation with cellular fusion
relationship: part_of GO:0000749 ! response to pheromone involved in conjugation with cellular fusion

[Term]
id: GO:0000753
name: cell morphogenesis involved in conjugation with cellular fusion
namespace: biological_process
alt_id: GO:0007332
def: "The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo conjugation cellular fusion." [GOC:clt]
synonym: "shmoo orientation" NARROW []
synonym: "shmooing" NARROW []
is_a: GO:0000767 ! cell morphogenesis involved in conjugation
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
intersection_of: GO:0000902 ! cell morphogenesis
intersection_of: part_of GO:0000747 ! conjugation with cellular fusion
relationship: part_of GO:0000747 ! conjugation with cellular fusion
relationship: part_of GO:0000749 ! response to pheromone involved in conjugation with cellular fusion

[Term]
id: GO:0000754
name: adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion
namespace: biological_process
alt_id: GO:0007331
alt_id: GO:0030453
def: "In organisms that undergo conjugation with cellular fusion, the process resulting in desensitization following exposure to pheromone stimulus that act to down-regulate further stimulation or block initial conjugation responses. An example of this is the adaptation to pheromone during conjugation with cellular fusion in Saccharomyces cerevisiae." [GOC:clt]
synonym: "adaptation of signalling pathway by response to pheromone involved in conjugation with cellular fusion" EXACT [GOC:mah]
synonym: "adaptation to pheromone during conjugation with cellular fusion" RELATED [GOC:dph, GOC:tb]
synonym: "desensitization to pheromone during conjugation with cellular fusion" EXACT []
is_a: GO:0022414 ! reproductive process
is_a: GO:0023058 ! adaptation of signaling pathway
relationship: part_of GO:0000749 ! response to pheromone involved in conjugation with cellular fusion

[Term]
id: GO:0000755
name: cytogamy
namespace: biological_process
alt_id: GO:0000218
alt_id: GO:0030462
def: "During conjugation with cellular fusion, the process resulting in creating a single cell from complementary mating types. The localized remodeling and dissolution of external protective structures allow the fusion of the plasma membranes and cytoplasmic mixing. An example of this process is found in Saccharomyces cerevisiae." [GOC:elh]
synonym: "zygote formation" RELATED []
is_a: GO:0022413 ! reproductive process in single-celled organism
relationship: part_of GO:0000747 ! conjugation with cellular fusion

[Term]
id: GO:0000756
name: response to pheromone involved in conjugation with mutual genetic exchange
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus during the process of conjugation without cellular fusion." [GOC:clt]
synonym: "response to pheromone involved in conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb]
is_a: GO:0007154 ! cell communication
is_a: GO:0071444 ! cellular response to pheromone
intersection_of: GO:0019236 ! response to pheromone
intersection_of: part_of GO:0000748 ! conjugation with mutual genetic exchange
relationship: part_of GO:0000748 ! conjugation with mutual genetic exchange

[Term]
id: GO:0000757
name: signal transduction involved in conjugation with mutual genetic exchange
namespace: biological_process
def: "A signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation without cellular fusion." [GOC:clt]
synonym: "signal transduction involved in conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb]
is_a: GO:0007186 ! G-protein coupled receptor signaling pathway
intersection_of: GO:0007165 ! signal transduction
intersection_of: part_of GO:0000748 ! conjugation with mutual genetic exchange
relationship: part_of GO:0000748 ! conjugation with mutual genetic exchange
relationship: part_of GO:0000756 ! response to pheromone involved in conjugation with mutual genetic exchange

[Term]
id: GO:0000758
name: agglutination involved in conjugation with mutual genetic exchange
namespace: biological_process
def: "During conjugation without cellular fusion, the aggregation or adhesion of compatible mating types via complementary cell-cell interactions." [GOC:elh]
synonym: "agglutination involved in conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb]
is_a: GO:0000771 ! agglutination involved in conjugation
is_a: GO:0098630 ! aggregation of unicellular organisms
intersection_of: GO:0098630 ! aggregation of unicellular organisms
intersection_of: part_of GO:0000748 ! conjugation with mutual genetic exchange
relationship: part_of GO:0000748 ! conjugation with mutual genetic exchange
relationship: part_of GO:0000756 ! response to pheromone involved in conjugation with mutual genetic exchange

[Term]
id: GO:0000759
name: cell morphogenesis involved in conjugation with mutual genetic exchange
namespace: biological_process
def: "The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo conjugation without cellular fusion." [GOC:clt]
synonym: "cellular morphogenesis involved in conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb]
is_a: GO:0000767 ! cell morphogenesis involved in conjugation
intersection_of: GO:0000902 ! cell morphogenesis
intersection_of: part_of GO:0000748 ! conjugation with mutual genetic exchange
relationship: part_of GO:0000748 ! conjugation with mutual genetic exchange
relationship: part_of GO:0000756 ! response to pheromone involved in conjugation with mutual genetic exchange

[Term]
id: GO:0000760
name: adaptation to pheromone involved in conjugation with mutual genetic exchange
namespace: biological_process
def: "In organisms that undergo conjugation without cellular fusion, the process resulting in desensitization following exposure to pheromone stimulus that act to down-regulate further stimulation or block initial conjugation responses." [GOC:clt]
synonym: "adaptation to pheromone involved conjugation without cellular fusion" RELATED [GOC:dph, GOC:tb]
synonym: "desensitization to pheromone during conjugation without cellular fusion" EXACT []
is_a: GO:0000756 ! response to pheromone involved in conjugation with mutual genetic exchange
is_a: GO:0022401 ! negative adaptation of signaling pathway

[Term]
id: GO:0000761
name: conjugant formation
namespace: biological_process
def: "During conjugation without cellular fusion, the process that results in pairing complementary mating types. Localized morphological, cytological, and cytoskeletal changes connect the mating types without cytoplasmic mixing." [GOC:elh]
is_a: GO:0000771 ! agglutination involved in conjugation
relationship: part_of GO:0000748 ! conjugation with mutual genetic exchange

[Term]
id: GO:0000762
name: pheromone-induced unidirectional conjugation
namespace: biological_process
def: "The process of unidirectional (polarized) transfer of genetic information in response to a pheromone. It involves direct cellular contact between a donor and recipient cell; the contact is followed by the formation of a cellular bridge that physically connects the cells; some or all of the chromosome(s) of one cell ('male') is then transferred into the other cell ('female'); unidirectional conjugation occurs between cells of different mating types." [GOC:elh]
is_a: GO:0009291 ! unidirectional conjugation

[Term]
id: GO:0000763
name: obsolete cell morphogenesis involved in unidirectional conjugation
namespace: biological_process
def: "OBSOLETE. The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo unidirectional conjugation." [GOC:clt]
comment: This term was made obsolete because unidirectional conjugation occurs only in prokaryotes, which do not undergo morphogenetic changes associated with conjugation. In short, the process described by this term does not occur.
synonym: "cell morphogenesis involved in unidirectional conjugation" EXACT []
is_obsolete: true

[Term]
id: GO:0000764
name: obsolete cellular morphogenesis involved in pheromone-induced unidirectional conjugation
namespace: biological_process
def: "OBSOLETE. The change in form (cell shape and size) that contributes to sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo pheromone-induced unidirectional conjugation." [GOC:clt]
comment: This term was made obsolete because unidirectional conjugation occurs only in prokaryotes, which do not undergo morphogenetic changes associated with conjugation. In short, the process described by this term does not occur.
synonym: "cellular morphogenesis during pheromone-induced unidirectional" RELATED [GOC:dph, GOC:tb]
synonym: "cellular morphogenesis involved in pheromone-induced unidirectional conjugation" EXACT []
is_obsolete: true

[Term]
id: GO:0000765
name: response to pheromone involved in pheromone-induced unidirectional conjugation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus that contributes to the process of pheromone-induced unidirectional conjugation." [GOC:clt]
synonym: "response to pheromone during pheromone-induced unidirectional" RELATED [GOC:dph, GOC:tb]
is_a: GO:0019236 ! response to pheromone
intersection_of: GO:0019236 ! response to pheromone
intersection_of: part_of GO:0000762 ! pheromone-induced unidirectional conjugation
relationship: part_of GO:0000762 ! pheromone-induced unidirectional conjugation

[Term]
id: GO:0000766
name: negative adaptation of signaling pathway by response to pheromone involved in pheromone-induced unidirectional conjugation
namespace: biological_process
def: "In organisms that undergo pheromone-induced unidirectional conjugation, the process involved in desensitization following exposure to pheromone stimulus that acts to down-regulate further stimulation or block initial conjugation responses." [GOC:clt]
synonym: "adaptation to pheromone during pheromone-induced unidirectional conjugation" RELATED [GOC:dph, GOC:tb]
synonym: "desensitization to pheromone during pheromone-induced unidirectional conjugation" EXACT []
synonym: "negative adaptation of signalling pathway by response to pheromone involved in pheromone-induced unidirectional conjugation" EXACT [GOC:mah]
is_a: GO:0022401 ! negative adaptation of signaling pathway
relationship: part_of GO:0000765 ! response to pheromone involved in pheromone-induced unidirectional conjugation

[Term]
id: GO:0000767
name: cell morphogenesis involved in conjugation
namespace: biological_process
def: "The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types." [GOC:elh]
is_a: GO:0000902 ! cell morphogenesis
intersection_of: GO:0000902 ! cell morphogenesis
intersection_of: part_of GO:0000746 ! conjugation
relationship: part_of GO:0000746 ! conjugation

[Term]
id: GO:0000768
name: syncytium formation by plasma membrane fusion
namespace: biological_process
def: "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:mtg_muscle, GOC:tb]
synonym: "cell fusion" BROAD []
synonym: "cell-cell fusion" EXACT []
is_a: GO:0006949 ! syncytium formation
intersection_of: GO:0006949 ! syncytium formation
intersection_of: has_part GO:0045026 ! plasma membrane fusion
relationship: has_part GO:0045026 ! plasma membrane fusion

[Term]
id: GO:0000769
name: syncytium formation by mitosis without cytokinesis
namespace: biological_process
def: "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by one or more rounds of nuclear division without cytokinesis." [GOC:mah, GOC:tb]
synonym: "syncytium formation by mitosis without cell division" RELATED [GOC:mah]
is_a: GO:0006949 ! syncytium formation
intersection_of: GO:0006949 ! syncytium formation
intersection_of: has_part GO:0033301 ! cell cycle comprising mitosis without cytokinesis
relationship: has_part GO:0033301 ! cell cycle comprising mitosis without cytokinesis

[Term]
id: GO:0000770
name: peptide pheromone export
namespace: biological_process
alt_id: GO:0007325
def: "The directed movement of a peptide pheromone out of a cell by a secretion or export pathway used solely for the export of peptide pheromones." [GOC:elh]
synonym: "a-factor export" NARROW []
is_a: GO:0009914 ! hormone transport
is_a: GO:0015833 ! peptide transport

[Term]
id: GO:0000771
name: agglutination involved in conjugation
namespace: biological_process
def: "The aggregation or adhesion of compatible mating types via complementary cell-cell interactions prior to the formation of irreversible cellular contacts during conjugation." [GOC:elh]
is_a: GO:0007157 ! heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
is_a: GO:0098610 ! adhesion between unicellular organisms
intersection_of: GO:0098610 ! adhesion between unicellular organisms
intersection_of: part_of GO:0000746 ! conjugation
relationship: part_of GO:0000746 ! conjugation

[Term]
id: GO:0000772
name: mating pheromone activity
namespace: molecular_function
def: "The activity of binding to and activating specific cell surface receptors, thereby inducing a behavioral or physiological response(s) from a responding organism or cell that leads to the transfer or union of genetic material between organisms or cells. The mating pheromone can either be retained on the cell surface or secreted." [GOC:clt, GOC:elh]
is_a: GO:0005186 ! pheromone activity

[Term]
id: GO:0000773
name: phosphatidyl-N-methylethanolamine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-dimethylethanolamine." [EC:2.1.1.71]
subset: gosubset_prok
synonym: "methyltransferase II" RELATED [EC:2.1.1.71]
synonym: "phosphatidyl-N-methylethanolamine methyltransferase activity" EXACT [EC:2.1.1.71]
synonym: "phosphatidyl-N-monomethylethanolamine methyltransferase activity" EXACT [EC:2.1.1.71]
synonym: "phosphatidylethanolamine methyltransferase I" RELATED [EC:2.1.1.71]
synonym: "phosphatidylmonomethylethanolamine methyltransferase activity" EXACT [EC:2.1.1.71]
synonym: "phospholipid methyltransferase activity" EXACT [EC:2.1.1.71]
synonym: "PLMT" EXACT []
synonym: "S-adenosyl-L-methionine:phosphatidyl-N-methylethanolamine N-methyltransferase activity" EXACT [EC:2.1.1.71]
xref: EC:2.1.1.71
xref: MetaCyc:2.1.1.71-RXN
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0000774
name: adenyl-nucleotide exchange factor activity
namespace: molecular_function
def: "Stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins." [GOC:kd]
subset: gosubset_prok
is_a: GO:0030554 ! adenyl nucleotide binding
is_a: GO:0060590 ! ATPase regulator activity

[Term]
id: GO:0000775
name: chromosome, centromeric region
namespace: cellular_component
alt_id: GO:0097521
def: "The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:cjm, GOC:elh, GOC:kmv, GOC:pr]
comment: Note that this term can be used in place of the obsolete cellular component term 'centromere ; GO:0005698'.
synonym: "centromere" RELATED []
synonym: "centromere complex" EXACT []
synonym: "chromosome, centric region" EXACT []
synonym: "chromosome, pericentric region" RELATED []
is_a: GO:0098687 ! chromosomal region

[Term]
id: GO:0000776
name: kinetochore
namespace: cellular_component
alt_id: GO:0005699
def: "A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh]
comment: Note that the kinetochore overlaps the centromeric DNA, but centromeric DNA is not part of the kinetochore.
subset: goslim_pir
xref: Wikipedia:Kinetochore
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000775 ! chromosome, centromeric region

[Term]
id: GO:0000777
name: condensed chromosome kinetochore
namespace: cellular_component
def: "A multisubunit complex that is located at the centromeric region of a condensed chromosome and provides an attachment point for the spindle microtubules." [GOC:elh]
is_a: GO:0000776 ! kinetochore
intersection_of: GO:0000776 ! kinetochore
intersection_of: part_of GO:0000793 ! condensed chromosome
relationship: part_of GO:0000779 ! condensed chromosome, centromeric region
relationship: part_of GO:0000793 ! condensed chromosome

[Term]
id: GO:0000778
name: condensed nuclear chromosome kinetochore
namespace: cellular_component
def: "A multisubunit complex that is located at the centromeric region of a condensed nuclear chromosome and provides an attachment point for the spindle microtubules." [GOC:elh]
is_a: GO:0000777 ! condensed chromosome kinetochore
is_a: GO:0044454 ! nuclear chromosome part
intersection_of: GO:0000776 ! kinetochore
intersection_of: part_of GO:0000794 ! condensed nuclear chromosome
relationship: part_of GO:0000780 ! condensed nuclear chromosome, centromeric region
relationship: part_of GO:0000794 ! condensed nuclear chromosome

[Term]
id: GO:0000779
name: condensed chromosome, centromeric region
namespace: cellular_component
def: "The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:elh, GOC:kmv]
comment: Note that this term can be used in place of the obsolete cellular component term 'centromere ; GO:0005698'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex.
synonym: "condensed chromosome, centric region" EXACT []
synonym: "condensed chromosome, centromere" RELATED []
synonym: "condensed chromosome, pericentric region" RELATED []
is_a: GO:0000775 ! chromosome, centromeric region
intersection_of: GO:0000775 ! chromosome, centromeric region
intersection_of: part_of GO:0000793 ! condensed chromosome
relationship: part_of GO:0000793 ! condensed chromosome

[Term]
id: GO:0000780
name: condensed nuclear chromosome, centromeric region
namespace: cellular_component
def: "The region of a condensed nuclear chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:elh, GOC:kmv]
comment: Note that this term can be used in place of the obsolete cellular component term 'centromere ; GO:0005698'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex.
synonym: "condensed nuclear chromosome, centric region" EXACT []
synonym: "condensed nuclear chromosome, centromere" RELATED []
synonym: "condensed nuclear chromosome, pericentric region" RELATED []
is_a: GO:0000779 ! condensed chromosome, centromeric region
is_a: GO:0044454 ! nuclear chromosome part
intersection_of: GO:0000779 ! condensed chromosome, centromeric region
intersection_of: part_of GO:0000794 ! condensed nuclear chromosome
intersection_of: part_of GO:0005634 ! nucleus
relationship: part_of GO:0000794 ! condensed nuclear chromosome
relationship: part_of GO:0005634 ! nucleus

[Term]
id: GO:0000781
name: chromosome, telomeric region
namespace: cellular_component
def: "The terminal region of a linear chromosome that includes the telomeric DNA repeats and associated proteins." [GOC:elh]
comment: Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex.
synonym: "telomere" RELATED []
is_a: GO:0098687 ! chromosomal region

[Term]
id: GO:0000782
name: telomere cap complex
namespace: cellular_component
def: "A complex of DNA and protein located at the end of a linear chromosome that protects and stabilizes a linear chromosome." [GOC:elh]
comment: Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific protein complex and not a region of the chromosome.
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0032993 ! protein-DNA complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000781 ! chromosome, telomeric region

[Term]
id: GO:0000783
name: nuclear telomere cap complex
namespace: cellular_component
def: "A complex of DNA and protein located at the end of a linear chromosome in the nucleus that protects and stabilizes a linear chromosome." [GOC:elh]
comment: Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific protein complex and not a region of the chromosome.
is_a: GO:0000782 ! telomere cap complex
is_a: GO:0044454 ! nuclear chromosome part
intersection_of: GO:0000782 ! telomere cap complex
intersection_of: part_of GO:0005634 ! nucleus
relationship: part_of GO:0000784 ! nuclear chromosome, telomeric region
relationship: part_of GO:0005634 ! nucleus

[Term]
id: GO:0000784
name: nuclear chromosome, telomeric region
namespace: cellular_component
def: "The terminal region of a linear nuclear chromosome that includes the telomeric DNA repeats and associated proteins." [GOC:elh]
comment: Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex.
synonym: "nuclear chromosome, telomere" EXACT []
is_a: GO:0000781 ! chromosome, telomeric region
is_a: GO:0044454 ! nuclear chromosome part
intersection_of: GO:0000781 ! chromosome, telomeric region
intersection_of: part_of GO:0005634 ! nucleus
relationship: part_of GO:0005634 ! nucleus

[Term]
id: GO:0000785
name: chromatin
namespace: cellular_component
alt_id: GO:0005717
def: "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]
comment: Chromosomes include parts that are not part of the chromatin.  Examples include the kinetochore.
synonym: "chromosome scaffold" RELATED []
xref: NIF_Subcellular:sao1615953555
is_a: GO:0032991 ! macromolecular complex
is_a: GO:0044427 ! chromosomal part

[Term]
id: GO:0000786
name: nucleosome
namespace: cellular_component
alt_id: GO:0005718
def: "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]
subset: goslim_pir
xref: Wikipedia:Nucleosome
is_a: GO:0032993 ! protein-DNA complex
is_a: GO:0044427 ! chromosomal part
is_a: GO:0044815 ! DNA packaging complex
relationship: part_of GO:0000785 ! chromatin

[Term]
id: GO:0000787
name: cytoplasmic nucleosome
namespace: cellular_component
def: "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA in the cytoplasm into higher order structures." [GOC:elh]
is_a: GO:0000786 ! nucleosome
is_a: GO:0044444 ! cytoplasmic part
intersection_of: GO:0000786 ! nucleosome
intersection_of: part_of GO:0005737 ! cytoplasm
relationship: part_of GO:0000789 ! cytoplasmic chromatin
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0000788
name: nuclear nucleosome
namespace: cellular_component
def: "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA in the nucleus into higher order structures." [GOC:elh]
is_a: GO:0000786 ! nucleosome
is_a: GO:0044454 ! nuclear chromosome part
intersection_of: GO:0000786 ! nucleosome
intersection_of: part_of GO:0005634 ! nucleus
relationship: part_of GO:0000790 ! nuclear chromatin
relationship: part_of GO:0005634 ! nucleus

[Term]
id: GO:0000789
name: cytoplasmic chromatin
namespace: cellular_component
def: "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the cytoplasm." [GOC:elh, PMID:20404130]
is_a: GO:0000785 ! chromatin
is_a: GO:0044444 ! cytoplasmic part
intersection_of: GO:0000785 ! chromatin
intersection_of: part_of GO:0005737 ! cytoplasm
relationship: part_of GO:0000229 ! cytoplasmic chromosome
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0000790
name: nuclear chromatin
namespace: cellular_component
def: "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus." [GOC:elh, PMID:20404130]
is_a: GO:0000785 ! chromatin
is_a: GO:0044454 ! nuclear chromosome part
intersection_of: GO:0000785 ! chromatin
intersection_of: part_of GO:0005634 ! nucleus
relationship: part_of GO:0005634 ! nucleus

[Term]
id: GO:0000791
name: euchromatin
namespace: cellular_component
def: "A dispersed and relatively uncompacted form of chromatin." [GOC:elh]
xref: NIF_Subcellular:sao445485807
xref: Wikipedia:Euchromatin
is_a: GO:0000785 ! chromatin

[Term]
id: GO:0000792
name: heterochromatin
namespace: cellular_component
def: "A compact and highly condensed form of chromatin." [GOC:elh]
xref: NIF_Subcellular:sao581845896
xref: Wikipedia:Heterochromatin
is_a: GO:0000785 ! chromatin

[Term]
id: GO:0000793
name: condensed chromosome
namespace: cellular_component
def: "A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure." [GOC:elh]
comment: Note that this term can be used to annotate gene products that localize to a mitotic chromosome in an organism that undergoes an 'open mitosis' in which the nuclear envelope breaks down during mitosis.
synonym: "cytoplasmic mitotic chromosome" RELATED []
synonym: "metaphase chromosome" RELATED []
synonym: "mitotic chromosome" RELATED []
is_a: GO:0005694 ! chromosome

[Term]
id: GO:0000794
name: condensed nuclear chromosome
namespace: cellular_component
def: "A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome." [GOC:elh]
comment: Note that this term and its children can be used to annotate gene products that localize to a mitotic chromosome in an organism that undergoes a 'closed mitosis' in which the nuclear envelope does not break down during mitosis and for gene products that localize to a meiotic chromosome.
synonym: "meiotic chromosome" RELATED []
synonym: "nuclear mitotic chromosome" RELATED []
is_a: GO:0000228 ! nuclear chromosome
is_a: GO:0000793 ! condensed chromosome
intersection_of: GO:0000793 ! condensed chromosome
intersection_of: part_of GO:0005634 ! nucleus
relationship: part_of GO:0005634 ! nucleus

[Term]
id: GO:0000795
name: synaptonemal complex
namespace: cellular_component
alt_id: GO:0005716
def: "A proteinaceous scaffold found between homologous chromosomes during meiosis." [GOC:elh]
xref: Wikipedia:Synaptonemal_complex
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000794 ! condensed nuclear chromosome

[Term]
id: GO:0000796
name: condensin complex
namespace: cellular_component
alt_id: GO:0005676
alt_id: GO:0008620
def: "A multisubunit protein complex that plays a central role in chromosome condensation." [GOC:elh]
subset: goslim_pir
synonym: "13S condensin complex" NARROW []
synonym: "SMC complex" RELATED []
is_a: GO:0044427 ! chromosomal part
is_a: GO:0044815 ! DNA packaging complex
relationship: part_of GO:0000793 ! condensed chromosome

[Term]
id: GO:0000797
name: condensin core heterodimer
namespace: cellular_component
alt_id: GO:0008621
def: "The core heterodimer of a condensin complex, a multisubunit protein complex that plays a central role in chromosome condensation." [GOC:elh]
synonym: "8S condensin complex" NARROW []
synonym: "Smc2-Smc4 complex" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
intersection_of: GO:0043234 ! protein complex
intersection_of: part_of GO:0000796 ! condensin complex
relationship: part_of GO:0000796 ! condensin complex

[Term]
id: GO:0000798
name: nuclear cohesin complex
namespace: cellular_component
def: "A cohesin complex required for cohesion between sister chromatids that remain in the nucleus." [GOC:elh]
comment: Note that this term and its children should be used to annotate gene products found in cohesin complexes in organisms that undergo closed mitosis (i.e. where the nuclear envelope does not break down, as in fungi). For organisms in which the nuclear envelope breaks down during mitosis, the parent should be used.
is_a: GO:0008278 ! cohesin complex
is_a: GO:0044454 ! nuclear chromosome part
intersection_of: GO:0008278 ! cohesin complex
intersection_of: part_of GO:0005634 ! nucleus
relationship: part_of GO:0000794 ! condensed nuclear chromosome
relationship: part_of GO:0005634 ! nucleus

[Term]
id: GO:0000799
name: nuclear condensin complex
namespace: cellular_component
def: "A multisubunit protein complex that plays a central role in the condensation of chromosomes that remain in the nucleus." [GOC:elh]
is_a: GO:0000796 ! condensin complex
is_a: GO:0044454 ! nuclear chromosome part
intersection_of: GO:0000796 ! condensin complex
intersection_of: part_of GO:0005634 ! nucleus
relationship: part_of GO:0000794 ! condensed nuclear chromosome
relationship: part_of GO:0005634 ! nucleus

[Term]
id: GO:0000800
name: lateral element
namespace: cellular_component
def: "A proteinaceous core found between sister chromatids during meiotic prophase." [GOC:elh]
synonym: "axial element" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000795 ! synaptonemal complex

[Term]
id: GO:0000801
name: central element
namespace: cellular_component
def: "A structural unit of the synaptonemal complex found between the lateral elements." [GOC:elh]
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000795 ! synaptonemal complex

[Term]
id: GO:0000802
name: transverse filament
namespace: cellular_component
def: "A structural unit of the synaptonemal complex that spans the regions between the lateral elements and connects them." [GOC:elh]
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000795 ! synaptonemal complex

[Term]
id: GO:0000803
name: sex chromosome
namespace: cellular_component
def: "A chromosome involved in sex determination." [GOC:elh]
is_a: GO:0005694 ! chromosome

[Term]
id: GO:0000804
name: W chromosome
namespace: cellular_component
def: "The sex chromosome present in females of species in which the female is the heterogametic sex; generally, the sex chromosome that pairs with the Z chromosome in the heterogametic sex. The W chromosome is absent from the cells of males and present in one copy in the somatic cells of females." [GOC:mah, ISBN:0321000382]
xref: Wikipedia:ZW_sex-determination_system
is_a: GO:0000803 ! sex chromosome

[Term]
id: GO:0000805
name: X chromosome
namespace: cellular_component
def: "The sex chromosome present in both sexes of species in which the male is the heterogametic sex. Two copies of the X chromosome are present in each somatic cell of females and one copy is present in males." [GOC:mah, ISBN:0582227089]
xref: Wikipedia:X_chromosome
is_a: GO:0000803 ! sex chromosome

[Term]
id: GO:0000806
name: Y chromosome
namespace: cellular_component
def: "The sex chromosome present in males of species in which the male is the heterogametic sex; generally, the sex chromosome that pairs with the X chromosome in the heterogametic sex. The Y chromosome is absent from the cells of females and present in one copy in the somatic cells of males." [GOC:mah, ISBN:0582227089]
xref: Wikipedia:Y_chromosome
is_a: GO:0000803 ! sex chromosome

[Term]
id: GO:0000807
name: Z chromosome
namespace: cellular_component
def: "The sex chromosome present in both sexes of species in which the female is the heterogametic sex. Two copies of the Z chromosome are present in each somatic cell of males and one copy is present in females." [GOC:mah, ISBN:0321000382]
xref: Wikipedia:ZW_sex-determination_system
is_a: GO:0000803 ! sex chromosome

[Term]
id: GO:0000808
name: origin recognition complex
namespace: cellular_component
def: "A multisubunit complex that is located at the replication origins of a chromosome." [GOC:elh]
subset: goslim_pir
subset: gosubset_prok
synonym: "ORC" EXACT []
synonym: "origin of replication recognition complex" EXACT []
xref: Wikipedia:Origin_recognition_complex
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part

[Term]
id: GO:0000809
name: cytoplasmic origin of replication recognition complex
namespace: cellular_component
def: "A multisubunit complex that is located at the replication origins of a chromosome in the cytoplasm." [GOC:elh]
subset: gosubset_prok
synonym: "cytoplasmic ORC" EXACT []
synonym: "prokaryotic ORC" RELATED []
is_a: GO:0000808 ! origin recognition complex
is_a: GO:0044444 ! cytoplasmic part
intersection_of: GO:0000808 ! origin recognition complex
intersection_of: part_of GO:0005737 ! cytoplasm
relationship: part_of GO:0000229 ! cytoplasmic chromosome
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0000810
name: diacylglycerol diphosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl-sn-glycerol 3-phosphate + phosphate." [EC:3.1.3.81, GOC:kad, MetaCyc:RXN-11277, PMID:8567632, PMID:9452443]
comment: The enzyme entry for EC 3.1.3.81 states that this is a bifunctional enzyme (http://www.chem.qmul.ac.uk/iubmb/enzyme/EC3/1/3/81.html). However, reaction details are only provided for the cumulative enzymatic activity, therefore this term has not been split into two.
synonym: "DGPP phosphatase activity" EXACT []
synonym: "DGPP phosphohydrolase activity" EXACT []
synonym: "diacylglycerol pyrophosphate phosphatase activity" EXACT []
xref: EC:3.1.3.81
xref: MetaCyc:RXN-11277
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0000811
name: GINS complex
namespace: cellular_component
def: "A heterotetrameric protein complex that associates with replication origins, where it is required for the initiation of DNA replication, and with replication forks." [GOC:rb, GOC:rn, PMID:12730134, PMID:16990792, PMID:17467990]
synonym: "Go, Ichi, Ni and San complex" EXACT []
is_a: GO:0031261 ! DNA replication preinitiation complex
is_a: GO:0044454 ! nuclear chromosome part

[Term]
id: GO:0000812
name: Swr1 complex
namespace: cellular_component
def: "A multisubunit protein complex that is involved in chromatin remodeling. It is required for the incorporation of the histone variant H2AZ into chromatin. In S. cerevisiae, the complex contains Swr1p, a Swi2/Snf2-related ATPase, and 12 additional subunits." [GOC:rb, PMID:14645854, PMID:14690608, PMID:19355820]
synonym: "SWR-C" EXACT []
is_a: GO:0044454 ! nuclear chromosome part
is_a: GO:0097346 ! INO80-type complex
relationship: part_of GO:0000790 ! nuclear chromatin

[Term]
id: GO:0000813
name: ESCRT I complex
namespace: cellular_component
def: "An endosomal sorting complex required for transport. It consists of the class E vacuolar protein sorting (Vps) proteins and interacts with ubiquitinated cargoes." [GOC:rb, PMID:12892785, PMID:12900393]
synonym: "Endosomal Sorting Complex Required for Transport" BROAD []
is_a: GO:0036452 ! ESCRT complex
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0010008 ! endosome membrane

[Term]
id: GO:0000814
name: ESCRT II complex
namespace: cellular_component
def: "An endosomal sorting complex required for transport and functions downstream of ESCRT I complex. It consists of the class E vacuolar protein sorting (Vps) proteins and is required for the membrane recruitment of ESCRT III complex and binds to ubiquitinated cargoes." [GOC:rb, PMID:12892785, PMID:12900393]
synonym: "Endosomal Sorting Complex Required for Transport" BROAD []
is_a: GO:0036452 ! ESCRT complex
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0010008 ! endosome membrane

[Term]
id: GO:0000815
name: ESCRT III complex
namespace: cellular_component
def: "An endosomal sorting complex required for transport. Consists of two soluble subcomplexes of highly charged coiled-coil proteins and is required for sorting and/or concentration of multivesicular body (MVB) cargoes." [GOC:rb, PMID:12892785, PMID:12900393]
synonym: "Endosomal Sorting Complex Required for Transport" BROAD []
is_a: GO:0036452 ! ESCRT complex
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0010008 ! endosome membrane

[Term]
id: GO:0000817
name: COMA complex
namespace: cellular_component
def: "A multiprotein complex in yeast consisting of Ctf19p, Okp1p, Mcm21p, and Ame1p. This complex bridges the subunits that are in contact with centromeric DNA and the subunits bound to microtubules during kinetochore assembly." [GOC:se, PMID:14633972]
synonym: "Ctf19p-Okp1p-Mcm1p-Ame1p complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000778 ! condensed nuclear chromosome kinetochore

[Term]
id: GO:0000818
name: nuclear MIS12/MIND complex
namespace: cellular_component
def: "A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore of a chromosome in the nucleus. It helps to recruit outer kinetochore subunits that will bind to microtubules. Nuclear localization arises in some organisms because the nuclear envelope is not broken down during mitosis. In S. cerevisiae, it consists of at least four proteins: Mtw1p, Nnf1p, Nsl1p, and Dsn1." [GOC:krc, GOC:se, PMID:14633972]
synonym: "MIND complex" EXACT []
synonym: "Mtw1p Including Nnf1p-Nsl1p-Dsn1p complex" EXACT []
is_a: GO:0000444 ! MIS12/MIND type complex
is_a: GO:0044454 ! nuclear chromosome part
intersection_of: GO:0000444 ! MIS12/MIND type complex
intersection_of: part_of GO:0005634 ! nucleus
relationship: part_of GO:0000778 ! condensed nuclear chromosome kinetochore
relationship: part_of GO:0005634 ! nucleus

[Term]
id: GO:0000819
name: sister chromatid segregation
namespace: biological_process
def: "The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets." [GOC:ai, GOC:elh]
is_a: GO:0051276 ! chromosome organization
is_a: GO:0098813 ! nuclear chromosome segregation
is_a: GO:1902589 ! single-organism organelle organization

[Term]
id: GO:0000820
name: regulation of glutamine family amino acid metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:go_curators]
synonym: "regulation of glutamine family amino acid metabolism" EXACT []
is_a: GO:0006521 ! regulation of cellular amino acid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009064 ! glutamine family amino acid metabolic process
relationship: regulates GO:0009064 ! glutamine family amino acid metabolic process

[Term]
id: GO:0000821
name: regulation of arginine metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [CHEBI:29016, GOC:go_curators]
synonym: "regulation of arginine metabolism" EXACT []
is_a: GO:0000820 ! regulation of glutamine family amino acid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006525 ! arginine metabolic process
relationship: regulates GO:0006525 ! arginine metabolic process

[Term]
id: GO:0000822
name: inositol hexakisphosphate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with inositol hexakisphosphate." [GOC:go_curators]
synonym: "InsP6 binding" EXACT []
synonym: "IP6 binding" EXACT []
is_a: GO:0043168 ! anion binding
is_a: GO:0043178 ! alcohol binding

[Term]
id: GO:0000823
name: inositol-1,4,5-trisphosphate 6-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-myo-inositol 1,4,5-trisphosphate + ATP = D-myo-inositol 1,4,5,6-tetrakisphosphate + ADP + 2 H(+)." [MetaCyc:2.7.1.151-RXN]
synonym: "ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase activity" EXACT []
synonym: "inositol polyphosphate multikinase activity" BROAD []
synonym: "inositol trisphosphate 6-kinase activity" BROAD []
synonym: "IpmK" BROAD []
xref: EC:2.7.1.151
xref: KEGG:R05800
xref: MetaCyc:2.7.1.151-RXN
is_a: GO:0051766 ! inositol trisphosphate kinase activity

[Term]
id: GO:0000824
name: inositol tetrakisphosphate 3-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate." [GOC:elh]
synonym: "1D-myo-inositol-tetrakisphosphate 3-kinase activity" EXACT []
synonym: "EC:2.7.1.151" BROAD []
synonym: "inositol 1,4,5,6-tetrakisphosphate 3-kinase activity" EXACT []
synonym: "inositol polyphosphate multikinase activity" BROAD []
synonym: "IpmK" BROAD []
is_a: GO:0051765 ! inositol tetrakisphosphate kinase activity

[Term]
id: GO:0000825
name: inositol tetrakisphosphate 6-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP." [GOC:elh]
synonym: "1D-myo-inositol-tetrakisphosphate 6-kinase activity" EXACT []
synonym: "inositol 1,3,4,5-tetrakisphosphate 6-kinase activity" EXACT []
xref: MetaCyc:RXN-7184
is_a: GO:0051765 ! inositol tetrakisphosphate kinase activity

[Term]
id: GO:0000826
name: obsolete inositol pyrophosphate synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the phosphorylation of inositol phosphates which possess diphosphate bonds." [GOC:elh, PMID:16429326]
comment: This term was made obsolete because it is incorrectly defined; 'inositol pyrophosphate' is a inositol derivative to which one (or more) pyrophosphate moieties are attached. 'Inositol pyrophosphate synthase' refers to a class of enzymes that catalyze various different reactions that result in the formation of an IP, so one cannot formulate a general reaction for them.
synonym: "inositol diphosphate synthase activity" EXACT []
synonym: "inositol pyrophosphate synthase activity" EXACT []
is_obsolete: true
consider: GO:0052746

[Term]
id: GO:0000827
name: inositol-1,3,4,5,6-pentakisphosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol tetrakisphosphate is unknown." [GOC:elh, PMID:11311242]
synonym: "EC:2.7.4.21" BROAD []
is_a: GO:0016301 ! kinase activity
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor

[Term]
id: GO:0000828
name: inositol hexakisphosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + diphospho-1D-myo-inositol-pentakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) is unknown." [GOC:elh, GOC:vw, PMID:16429326]
is_a: GO:0016301 ! kinase activity
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor

[Term]
id: GO:0000829
name: inositol heptakisphosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + diphospho-1D-myo-inositol-pentakisphosphate = ADP + bis(diphospho)-1D-myo-inositol-tetrakisphosphate. The isomeric configurations of the diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) and bis(diphospho)-1D-myo-inositol-tetrakisphosphate (bis-PP-IP4) are unknown." [GOC:elh, PMID:16429326]
is_a: GO:0016301 ! kinase activity
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor

[Term]
id: GO:0000830
name: inositol hexakisphosphate 4-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate." [GOC:elh, PMID:16429326]
is_a: GO:0000828 ! inositol hexakisphosphate kinase activity

[Term]
id: GO:0000831
name: inositol hexakisphosphate 6-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate." [GOC:elh, PMID:16429326]
is_a: GO:0000828 ! inositol hexakisphosphate kinase activity

[Term]
id: GO:0000832
name: inositol hexakisphosphate 5-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate." [MetaCyc:2.7.1.152-RXN]
synonym: "ATP:1D-myo-inositol-hexakisphosphate 5-phosphotransferase activity" EXACT []
xref: EC:2.7.4.21
xref: KEGG:R09087
xref: MetaCyc:2.7.1.152-RXN
is_a: GO:0000828 ! inositol hexakisphosphate kinase activity

[Term]
id: GO:0000833
name: inositol heptakisphosphate 4-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 4,5-bisdiphosphoinositol-1D-myoinositol (1,2,3,6)tetrakisphosphate." [GOC:elh, PMID:16429326]
synonym: "diphosphoinositol-pentakisphosphate 4-kinase activity" EXACT []
synonym: "IP7 4-kinase activity" EXACT []
is_a: GO:0000829 ! inositol heptakisphosphate kinase activity

[Term]
id: GO:0000834
name: inositol heptakisphosphate 6-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 5,6-bisdiphosphoinositol-1D-myoinositol (1,2,3,4)tetrakisphosphate." [GOC:elh, PMID:16429326]
is_a: GO:0000829 ! inositol heptakisphosphate kinase activity

[Term]
id: GO:0000835
name: ER ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex found in the ER." [GOC:elh]
is_a: GO:0000153 ! cytoplasmic ubiquitin ligase complex
is_a: GO:0000502 ! proteasome complex
is_a: GO:0044432 ! endoplasmic reticulum part
is_a: GO:0098796 ! membrane protein complex
intersection_of: GO:0000151 ! ubiquitin ligase complex
intersection_of: part_of GO:0005783 ! endoplasmic reticulum
relationship: part_of GO:0005783 ! endoplasmic reticulum
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane

[Term]
id: GO:0000836
name: Hrd1p ubiquitin ligase complex
namespace: cellular_component
def: "A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal and membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p. In mammals, this complex contains the ubiquitin ligase HRD1 (Synoviolin) or AMFR (gp78)." [GOC:bf, GOC:elh, PMID:16619026, PMID:16873066, PMID:21454652]
synonym: "HRD1 ubiquitin ligase complex" RELATED [GOC:bf]
is_a: GO:0000835 ! ER ubiquitin ligase complex

[Term]
id: GO:0000837
name: Doa10p ubiquitin ligase complex
namespace: cellular_component
def: "A multiprotein complex that recognizes and ubiquitinates membrane proteins with misfolded cytosolic domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Ssm4p/Doa10p." [GOC:elh, PMID:16873066]
synonym: "Ssm4p ubiquitin ligase complex" EXACT []
is_a: GO:0000835 ! ER ubiquitin ligase complex

[Term]
id: GO:0000838
name: Hrd1p ubiquitin ligase ERAD-M complex
namespace: cellular_component
def: "A multiprotein complex that recognizes and ubiquitinates proteins with misfolded membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p." [GOC:elh, PMID:16873066]
is_a: GO:0000836 ! Hrd1p ubiquitin ligase complex

[Term]
id: GO:0000839
name: Hrd1p ubiquitin ligase ERAD-L complex
namespace: cellular_component
def: "A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p." [GOC:elh, PMID:16873065, PMID:16873066]
is_a: GO:0000836 ! Hrd1p ubiquitin ligase complex

[Term]
id: GO:0000900
name: translation repressor activity, nucleic acid binding
namespace: molecular_function
def: "Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding (through a selective and non-covalent interaction) to nucleic acid." [GOC:clt, GOC:vw]
is_a: GO:0030371 ! translation repressor activity
is_a: GO:0090079 ! translation regulator activity, nucleic acid binding

[Term]
id: GO:0000901
name: translation repressor activity, non-nucleic acid binding
namespace: molecular_function
def: "Antagonizes the ribosome-mediated translation of mRNA into a polypeptide but does not bind directly to nucleic acid." [GOC:clt]
is_a: GO:0030371 ! translation repressor activity
is_a: GO:0045183 ! translation factor activity, non-nucleic acid binding

[Term]
id: GO:0000902
name: cell morphogenesis
namespace: biological_process
alt_id: GO:0007148
alt_id: GO:0045790
alt_id: GO:0045791
def: "The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_yeast
subset: gosubset_prok
synonym: "cellular morphogenesis" EXACT []
is_a: GO:0032989 ! cellular component morphogenesis

[Term]
id: GO:0000903
name: regulation of cell shape during vegetative growth phase
namespace: biological_process
alt_id: GO:0090061
def: "Any process that modulates the surface configuration of a cell during the vegetative growth phase. The vegetative growth phase is the growth phase during which single celled organisms reproduce by budding or other asexual methods." [GOC:clt, GOC:go_curators, GOC:vw]
synonym: "cell morphogenesis during vegetative growth phase" RELATED [GOC:vw]
synonym: "cellular morphogenesis during vegetative growth" RELATED [GOC:dph, GOC:tb]
synonym: "regulation of cell morphogenesis during vegetative growth phase" RELATED []
is_a: GO:0008360 ! regulation of cell shape
intersection_of: GO:0008360 ! regulation of cell shape
intersection_of: part_of GO:0072690 ! single-celled organism vegetative growth phase
relationship: part_of GO:0072690 ! single-celled organism vegetative growth phase

[Term]
id: GO:0000904
name: cell morphogenesis involved in differentiation
namespace: biological_process
def: "The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:go_curators]
is_a: GO:0000902 ! cell morphogenesis
intersection_of: GO:0000902 ! cell morphogenesis
intersection_of: part_of GO:0048468 ! cell development
relationship: part_of GO:0048468 ! cell development

[Term]
id: GO:0000905
name: sporocarp development involved in asexual reproduction
namespace: biological_process
def: "The formation of a spore-bearing structure by fungus where spores will arise from asexual reproduction." [GOC:clt, GOC:mtg_sensu]
synonym: "conidium development" NARROW []
synonym: "fruiting body formation involved in asexual reproduction" BROAD []
synonym: "haploid fruiting" RELATED []
synonym: "homokaryotic fruiting" RELATED []
synonym: "imperfect stage fruiting body development" NARROW []
synonym: "monokaryotic fruiting" RELATED []
is_a: GO:0030584 ! sporocarp development
intersection_of: GO:0030584 ! sporocarp development
intersection_of: part_of GO:0019954 ! asexual reproduction
relationship: part_of GO:0019954 ! asexual reproduction

[Term]
id: GO:0000906
name: 6,7-dimethyl-8-ribityllumazine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,4-dihydroxy-2-butanone-4-phosphate + 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione = 6,7-dimethyl-8-ribityllumazine + phosphate." [EC:5.4.-.-, PMID:7559556]
synonym: "lumazine synthase activity" BROAD [MetaCyc:LUMAZINESYN-CPLX]
xref: EC:5.4.-.-
is_a: GO:0016867 ! intramolecular transferase activity, transferring acyl groups

[Term]
id: GO:0000907
name: sulfonate dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: sulfonate + 2-oxoglutarate + O2 = sulfite + aminoacetaldehyde + succinate + CO2." [EC:1.14.11.-, GOC:clt, PMID:10482536]
subset: gosubset_prok
synonym: "sulfonate/alpha-ketoglutarate dioxygenase activity" EXACT []
synonym: "sulphonate dioxygenase activity" EXACT []
xref: EC:1.14.11.-
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0000908
name: taurine dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + O(2) + taurine = aminoacetaldehyde + CO(2) + succinate + sulfite." [EC:1.14.11.17, RHEA:15912]
subset: gosubset_prok
synonym: "2-aminoethanesulfonate dioxygenase activity" EXACT [EC:1.14.11.17]
synonym: "alpha-ketoglutarate-dependent taurine dioxygenase activity" EXACT [EC:1.14.11.17]
synonym: "taurine, 2-oxoglutarate:O2 oxidoreductase (sulfite-forming)" EXACT [EC:1.14.11.17]
xref: EC:1.14.11.17
xref: KEGG:R05320
xref: MetaCyc:RXN0-299
xref: RHEA:15912
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0000909
name: sporocarp development involved in sexual reproduction
namespace: biological_process
def: "The process whose specific outcome is the progression of a fruiting body organ over time, from its formation to the mature structure. The fruiting body is a spore bearing structure. In fungi, the sporocarp (also known as fruiting body) is a multicellular structure on which spore-producing structures, such as basidia or asci, are borne. The fruiting body is part of the sexual phase of a fungal life cycle, with the rest of the life cycle being characterized by vegetative mycelial growth. The sporocarp of a basidiomycete is known as a basidiocarp, while the fruiting body of an ascomycete is known as an ascocarp. A significant range of different shapes and morphologies is found in both basidiocarps and ascocarps; these features play an important role in the identification and taxonomy of fungi." [GOC:clt, GOC:mtg_sensu]
synonym: "ascus development" NARROW []
synonym: "fruiting body development involved in sexual reproduction" BROAD []
synonym: "fruiting body formation involved in sexual reproduction" BROAD []
synonym: "perfect stage fruiting body development" NARROW []
is_a: GO:0030584 ! sporocarp development
intersection_of: GO:0030584 ! sporocarp development
intersection_of: part_of GO:0019953 ! sexual reproduction
relationship: part_of GO:0019953 ! sexual reproduction

[Term]
id: GO:0000910
name: cytokinesis
namespace: biological_process
alt_id: GO:0007104
alt_id: GO:0016288
alt_id: GO:0033205
def: "The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells." [GOC:mtg_cell_cycle]
comment: Note that when annotating eukaryotic species, mitotic or meiotic cytokinesis should always be specified for manual annotation and for prokaryotic species use 'FtsZ-dependent cytokinesis ; GO:0043093' or Cdv-dependent cytokinesis ; GO:0061639.  Also, note that cytokinesis does not necessarily result in physical separation and detachment of the two daughter cells from each other.
subset: gocheck_do_not_manually_annotate
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_yeast
subset: gosubset_prok
synonym: "cell cycle cytokinesis" EXACT []
synonym: "cytokinesis involved in cell cycle" EXACT [GOC:dph, GOC:tb]
xref: Reactome:REACT_101918 "Mitotic Telophase /Cytokinesis, Mus musculus"
xref: Reactome:REACT_108805 "Mitotic Telophase /Cytokinesis, Dictyostelium discoideum"
xref: Reactome:REACT_1932 "Mitotic Telophase /Cytokinesis, Homo sapiens"
xref: Reactome:REACT_30667 "Mitotic Telophase /Cytokinesis, Schizosaccharomyces pombe"
xref: Reactome:REACT_32636 "Mitotic Telophase /Cytokinesis, Bos taurus"
xref: Reactome:REACT_78494 "Mitotic Telophase /Cytokinesis, Danio rerio"
xref: Reactome:REACT_84722 "Mitotic Telophase /Cytokinesis, Gallus gallus"
xref: Reactome:REACT_87726 "Mitotic Telophase /Cytokinesis, Xenopus tropicalis"
xref: Reactome:REACT_92849 "Mitotic Telophase /Cytokinesis, Taeniopygia guttata"
xref: Reactome:REACT_93374 "Mitotic Telophase /Cytokinesis, Canis familiaris"
xref: Reactome:REACT_94382 "Mitotic Telophase /Cytokinesis, Drosophila melanogaster"
xref: Reactome:REACT_98952 "Mitotic Telophase /Cytokinesis, Rattus norvegicus"
xref: Reactome:REACT_99118 "Mitotic Telophase /Cytokinesis, Caenorhabditis elegans"
xref: Wikipedia:Cytokinesis
is_a: GO:0022402 ! cell cycle process
relationship: has_part GO:0090148 ! membrane fission
relationship: part_of GO:0051301 ! cell division

[Term]
id: GO:0000911
name: cytokinesis by cell plate formation
namespace: biological_process
def: "The process of dividing the cytoplasm of a parent cell where a structure forms in the cytoplasm and grows until reaching the plasma membrane, thereby completely separating the cytoplasms of adjacent progeny cells. An example of this is found in Arabidopsis thaliana." [GOC:clt]
is_a: GO:1902410 ! mitotic cytokinetic process

[Term]
id: GO:0000912
name: assembly of actomyosin apparatus involved in cytokinesis
namespace: biological_process
def: "The assembly and arrangement of an apparatus composed of actin, myosin, and associated proteins that will function in cytokinesis." [GOC:mtg_cell_cycle]
synonym: "actomyosin apparatus assembly involved in cytokinesis" EXACT [GOC:mah]
synonym: "cytokinesis, formation of actomyosin apparatus" EXACT [GOC:dph, GOC:tb]
synonym: "formation of actomyosin apparatus involved in cytokinesis" RELATED [GOC:dph]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0032506 ! cytokinetic process
relationship: part_of GO:0061640 ! cytoskeleton-dependent cytokinesis

[Term]
id: GO:0000913
name: preprophase band assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the preprophase band, a dense band of microtubules that marks the position in the cell where cytokinesis will occur in cells that perform cytokinesis by cell plate formation." [GOC:clt, GOC:mah]
synonym: "preprophase band formation" RELATED [GOC:mah]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:1902408 ! mitotic cytokinesis, site selection
relationship: part_of GO:0000911 ! cytokinesis by cell plate formation

[Term]
id: GO:0000914
name: phragmoplast assembly
namespace: biological_process
def: "The formation of a structure composed of actin, myosin, and associated proteins that will function in cytokinesis in cells that perform cytokinesis by cell plate formation. The structure usually contains antiparallel microtubules and membrane (often visible as vesicles)." [GOC:clt]
synonym: "phragmoplast formation" RELATED [goc:dph]
is_a: GO:1902407 ! assembly of actomyosin apparatus involved in mitotic cytokinesis
relationship: part_of GO:0000911 ! cytokinesis by cell plate formation

[Term]
id: GO:0000915
name: actomyosin contractile ring assembly
namespace: biological_process
alt_id: GO:0045573
def: "The process of assembly of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis." [GOC:clt, GOC:dph, GOC:tb]
synonym: "constriction ring assembly" NARROW []
synonym: "contractile ring assembly" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "cytokinesis, actomyosin contractile ring assembly" EXACT []
synonym: "cytokinesis, actomyosin contractile ring formation" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "cytokinesis, actomyosin ring biosynthesis" RELATED []
synonym: "cytokinesis, actomyosin ring formation" RELATED []
synonym: "cytokinesis, contractile ring assembly" RELATED [GOC:mah]
is_a: GO:0000912 ! assembly of actomyosin apparatus involved in cytokinesis
is_a: GO:0044837 ! actomyosin contractile ring organization

[Term]
id: GO:0000916
name: actomyosin contractile ring contraction
namespace: biological_process
def: "The process of an actomyosin ring getting smaller in diameter, in the context of cytokinesis that takes place as part of a cell cycle." [GOC:clt, GOC:dph, GOC:mah, GOC:tb]
synonym: "contractile ring constriction" BROAD [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "contractile ring contraction involved in cell cycle cytokinesis" EXACT [GOC:mah, GOC:vw]
synonym: "cytokinesis, actomyosin ring contraction" EXACT []
synonym: "cytokinesis, contractile ring contraction" BROAD [GOC:dph, GOC:tb]
is_a: GO:0036213 ! contractile ring contraction
relationship: part_of GO:0061640 ! cytoskeleton-dependent cytokinesis

[Term]
id: GO:0000917
name: barrier septum assembly
namespace: biological_process
alt_id: GO:0071937
alt_id: GO:1902411
def: "The assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. The progeny cells that form a barrier septum are not able to exchange intracellular material." [GOC:mtg_cell_cycle]
synonym: "barrier septum assembly involved in cell cycle cytokinesis" EXACT []
synonym: "barrier septum assembly involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "barrier septum formation" EXACT [GOC:mah]
synonym: "barrier septum formation involved in cell cycle cytokinesis" EXACT []
synonym: "barrier septum formation involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "barrier septum formation involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "formation of barrier septum" EXACT []
synonym: "formation of barrier septum involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "mitotic barrier septum assembly" EXACT []
synonym: "septation" BROAD []
synonym: "septin assembly and septum biosynthesis" RELATED []
synonym: "septin assembly and septum biosynthesis involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "septin assembly and septum formation" RELATED []
synonym: "septin assembly and septum formation involved in mitotic cell cycle" RELATED [GOC:TermGenie]
is_a: GO:0090529 ! cell septum assembly
is_a: GO:1902410 ! mitotic cytokinetic process
relationship: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0000281 ! mitotic cytokinesis
relationship: part_of GO:0061640 ! cytoskeleton-dependent cytokinesis

[Term]
id: GO:0000918
name: barrier septum site selection
namespace: biological_process
def: "The process of marking the site where a barrier septum will form." [GOC:clt]
synonym: "selection of site for barrier cell septum biosynthesis" EXACT []
synonym: "selection of site for barrier cell septum formation" EXACT []
synonym: "selection of site for barrier septum formation" EXACT [GOC:curators]
synonym: "septin assembly and septum biosynthesis" BROAD []
synonym: "septin assembly and septum formation" BROAD []
synonym: "septum positioning" EXACT []
is_a: GO:1902410 ! mitotic cytokinetic process
relationship: part_of GO:0000917 ! barrier septum assembly

[Term]
id: GO:0000919
name: cell plate assembly
namespace: biological_process
def: "The process of assembly, maturation, and growth of the cell plate to the cell periphery in cells that divide by cell plate formation; often involves deposition of cell wall material in and around the phragmoplast." [GOC:clt]
synonym: "cell plate formation" RELATED [GOC:mah]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:1902410 ! mitotic cytokinetic process
relationship: part_of GO:0000911 ! cytokinesis by cell plate formation

[Term]
id: GO:0000920
name: cell separation after cytokinesis
namespace: biological_process
alt_id: GO:1902409
alt_id: GO:2000695
def: "The process of physically separating progeny cells after cytokinesis; this may involve enzymatic digestion of septum or cell wall components." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "cell separation following cytokinesis" EXACT [GOC:dph, GOC:tb]
synonym: "cytokinetic cell separation" RELATED []
synonym: "mitotic cytokinetic cell separation" EXACT []
synonym: "rotokinesis" NARROW []
is_a: GO:0009987 ! cellular process
relationship: part_of GO:0051301 ! cell division

[Term]
id: GO:0000921
name: septin ring assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of septins and associated proteins to form an organized structure resembling a ring at the cell cortex." [GOC:clt]
subset: gosubset_prok
synonym: "septin assembly and septum biosynthesis" BROAD []
synonym: "septin assembly and septum formation" BROAD []
is_a: GO:0031106 ! septin ring organization
is_a: GO:0043623 ! cellular protein complex assembly
is_a: GO:0070925 ! organelle assembly

[Term]
id: GO:0000922
name: spindle pole
namespace: cellular_component
alt_id: GO:0030615
def: "Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt]
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0005819 ! spindle

[Term]
id: GO:0000923
name: equatorial microtubule organizing center
namespace: cellular_component
def: "A microtubule organizing center formed by a band of gamma-tubulin that is recruited to a circumferential band of F-actin at the midpoint of a cell and which nucleates microtubules from the cell division site at the end of mitosis." [PMID:11792817]
synonym: "EMTOC" EXACT []
synonym: "equatorial microtubule organising centre" EXACT []
is_a: GO:0005815 ! microtubule organizing center
is_a: GO:0032155 ! cell division site part
intersection_of: GO:0005815 ! microtubule organizing center
intersection_of: part_of GO:0032153 ! cell division site
relationship: part_of GO:0032153 ! cell division site

[Term]
id: GO:0000924
name: gamma-tubulin ring complex, centrosomal
namespace: cellular_component
alt_id: GO:0000925
alt_id: GO:0000926
def: "A centrosome-localized multiprotein complex composed of gamma-tubulin and other non-tubulin proteins assembled into a ring structure that is thought to be the unit of nucleation at the minus end of a microtubule. Gamma-tubulin small complexes are thought to be the core repeating units of the ring." [GOC:clt, GOC:mtg_sensu, PMID:12134075, PMID:17021256]
synonym: "gamma-tubulin large complex, centrosomal" EXACT []
is_a: GO:0008274 ! gamma-tubulin ring complex
intersection_of: GO:0008274 ! gamma-tubulin ring complex
intersection_of: part_of GO:0000242 ! pericentriolar material
relationship: part_of GO:0000242 ! pericentriolar material

[Term]
id: GO:0000927
name: gamma-tubulin small complex, centrosomal
namespace: cellular_component
def: "A centrosomal complex usually comprising two gamma-tubulin molecules, at least two conserved non-tubulin proteins that multimerize along with additional non-tubulin proteins in animal cells into larger functional complexes. Gamma-tubulin small complexes are thought to be the repeating unit making up the core of the gamma-tubulin ring complex. An example of this structure is found in Mus musculus." [GOC:mtg_sensu, PMID:12134075]
is_a: GO:0008275 ! gamma-tubulin small complex

[Term]
id: GO:0000928
name: gamma-tubulin small complex, spindle pole body
namespace: cellular_component
def: "A complex composed of two gamma-tubulin molecules and conserved non-tubulin proteins located in the spindle pole body and isolated by fractionation from cells. The complex, approximately 6S-9S, is analogous to the small complex in animal cells but contains fewer subunits, and is not thought to multimerize into larger functional units, like complexes in those organisms. An example of this structure is found in Saccharomyces cerevisiae." [GOC:mtg_sensu, PMID:12134075]
synonym: "Tub4 complex" EXACT []
is_a: GO:0008275 ! gamma-tubulin small complex
intersection_of: GO:0008275 ! gamma-tubulin small complex
intersection_of: part_of GO:0005816 ! spindle pole body
relationship: part_of GO:0005816 ! spindle pole body

[Term]
id: GO:0000930
name: gamma-tubulin complex
namespace: cellular_component
def: "A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins. Gamma-tubulin complexes are localized to microtubule organizing centers, and play an important role in the nucleation of microtubules. The number and complexity of non-tubulin proteins associated with these complexes varies between species." [GOC:clt, PMID:12134075]
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044450 ! microtubule organizing center part

[Term]
id: GO:0000931
name: gamma-tubulin large complex
namespace: cellular_component
alt_id: GO:0000929
def: "A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes. An example of this structure is found in Schizosaccharomyces pombe." [GOC:mtg_sensu, PMID:12134075]
is_a: GO:0000930 ! gamma-tubulin complex

[Term]
id: GO:0000932
name: cytoplasmic mRNA processing body
namespace: cellular_component
def: "A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. mRNA processing and binding proteins are localized to these foci." [GOC:clt, PMID:12730603]
synonym: "cytoplasmic foci" RELATED []
synonym: "P body" EXACT []
synonym: "P-body" EXACT []
xref: Wikipedia:P_body
is_a: GO:0036464 ! cytoplasmic ribonucleoprotein granule

[Term]
id: GO:0000933
name: adventitious septum
namespace: cellular_component
def: "A cell septum whose formation is independent of nuclear division." [GOC:clt, ISBN:0471940526]
is_a: GO:0030428 ! cell septum

[Term]
id: GO:0000934
name: porous cell septum
namespace: cellular_component
def: "A septum or cross wall which does not entirely span the space between two portions of cell wall and may contain a specialized central pore structure. A porous septum allows the movement of organelles and/or cytoplasm between compartments." [GOC:clt]
synonym: "porous septum" BROAD []
is_a: GO:0030428 ! cell septum

[Term]
id: GO:0000935
name: barrier septum
namespace: cellular_component
def: "A septum which spans a cell and does not allow exchange of organelles or cytoplasm between compartments." [GOC:clt]
synonym: "complete septum" EXACT []
is_a: GO:0030428 ! cell septum

[Term]
id: GO:0000936
name: primary cell septum
namespace: cellular_component
def: "A cell septum that forms following nuclear division." [GOC:clt, ISBN:0471940526]
synonym: "primary septum" BROAD []
is_a: GO:0030428 ! cell septum

[Term]
id: GO:0000937
name: dolipore septum
namespace: cellular_component
def: "A septum, or cross-wall, between two portions of a cell or hypha; contains a central pore around which the septum is swollen to form a barrel-shaped structure; pore is covered on each side of the septum by a septal pore cap (parenthosome)." [GOC:clt]
is_a: GO:0000934 ! porous cell septum

[Term]
id: GO:0000938
name: GARP complex
namespace: cellular_component
def: "A quatrefoil tethering complex required for retrograde traffic from the early endosome back to the late Golgi and biogenesis of cytoplasmic vesicles." [GOC:clt, GOC:rn, PMID:10637310, PMID:12077354, PMID:12446664]
synonym: "Golgi associated retrograde protein complex" EXACT []
synonym: "VFT tethering complex" EXACT []
synonym: "Vps fifty three tethering complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044431 ! Golgi apparatus part
is_a: GO:0044433 ! cytoplasmic vesicle part
relationship: part_of GO:0016023 ! cytoplasmic, membrane-bounded vesicle

[Term]
id: GO:0000939
name: condensed chromosome inner kinetochore
namespace: cellular_component
def: "The region of a condensed chromosome kinetochore closest to centromeric DNA; in mammals the CREST antigens (CENP proteins) are found in this layer; this layer may help define underlying centromeric chromatin structure and position of the kinetochore on the chromosome." [GOC:clt, PMID:10619130, PMID:11483983]
synonym: "inner centromere core complex" RELATED []
synonym: "inner kinetochore of condensed chromosome" EXACT [GOC:curators]
synonym: "inner kinetochore plate" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000777 ! condensed chromosome kinetochore

[Term]
id: GO:0000940
name: condensed chromosome outer kinetochore
namespace: cellular_component
def: "The region of a condensed chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions." [GOC:clt, PMID:11483983]
synonym: "outer kinetochore of condensed chromosome" EXACT [GOC:curators]
synonym: "outer kinetochore plate" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000777 ! condensed chromosome kinetochore

[Term]
id: GO:0000941
name: condensed nuclear chromosome inner kinetochore
namespace: cellular_component
def: "The region of a condensed nuclear chromosome kinetochore closest to centromeric DNA; this layer may help define underlying centromeric chromatin structure and position of the kinetochore on the chromosome." [GOC:clt, PMID:10619130, PMID:1148398]
synonym: "inner kinetochore of condensed nuclear chromosome" EXACT [GOC:curators]
is_a: GO:0000939 ! condensed chromosome inner kinetochore
is_a: GO:0044454 ! nuclear chromosome part
intersection_of: GO:0000939 ! condensed chromosome inner kinetochore
intersection_of: part_of GO:0000778 ! condensed nuclear chromosome kinetochore
relationship: part_of GO:0000778 ! condensed nuclear chromosome kinetochore

[Term]
id: GO:0000942
name: condensed nuclear chromosome outer kinetochore
namespace: cellular_component
def: "The region of a condensed nuclear chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions." [GOC:clt, PMID:1148398]
synonym: "outer kinetochore of condensed nuclear chromosome" EXACT [GOC:curators]
is_a: GO:0000940 ! condensed chromosome outer kinetochore
is_a: GO:0044454 ! nuclear chromosome part
intersection_of: GO:0000940 ! condensed chromosome outer kinetochore
intersection_of: part_of GO:0000778 ! condensed nuclear chromosome kinetochore
relationship: part_of GO:0000778 ! condensed nuclear chromosome kinetochore

[Term]
id: GO:0000943
name: retrotransposon nucleocapsid
namespace: cellular_component
def: "A complex of the retrotransposon RNA genome, reverse transcriptase, integrase, and associated molecules required for reproduction and integration of the retrotransposon into the host genome; the main structural molecule of the nucleocapsid is often a gag protein homolog." [GOC:clt, PMID:10861903]
synonym: "Virus-like particle" EXACT []
synonym: "VLP" EXACT []
xref: Wikipedia:Virus-like_particle
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0000944
name: base pairing with rRNA
namespace: molecular_function
def: "Interacting selectively and non-covalently with ribosomal ribonucleic acid (rRNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target rRNA molecule." [GOC:krc]
comment: Note that with respect to annotation, "base pairing with RNA" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other RNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function.
is_a: GO:0000498 ! base pairing with RNA
is_a: GO:0019843 ! rRNA binding

[Term]
id: GO:0000945
name: base pairing with snRNA
namespace: molecular_function
def: "Interacting selectively and non-covalently with small nuclear ribonucleic acid (snRNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target snRNA molecule." [GOC:krc]
comment: Note that with respect to annotation, "base pairing with RNA" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other RNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function.
is_a: GO:0000498 ! base pairing with RNA
is_a: GO:0017069 ! snRNA binding

[Term]
id: GO:0000946
name: base pairing with tRNA
namespace: molecular_function
def: "Interacting selectively and non-covalently with transfer ribonucleic acid (mRNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target tRNA molecule." [GOC:krc]
comment: Note that with respect to annotation, "base pairing with RNA" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other RNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function.
is_a: GO:0000049 ! tRNA binding
is_a: GO:0000498 ! base pairing with RNA

[Term]
id: GO:0000947
name: amino acid catabolic process to alcohol via Ehrlich pathway
namespace: biological_process
def: "The chemical reactions and pathways involving the catabolism of amino acids to produce alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols." [GOC:krc, PMID:18281432]
is_a: GO:0000955 ! amino acid catabolic process via Ehrlich pathway
is_a: GO:0046165 ! alcohol biosynthetic process

[Term]
id: GO:0000948
name: amino acid catabolic process to carboxylic acid via Ehrlich pathway
namespace: biological_process
def: "The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids." [GOC:krc, PMID:18281432]
is_a: GO:0000955 ! amino acid catabolic process via Ehrlich pathway
is_a: GO:0046394 ! carboxylic acid biosynthetic process

[Term]
id: GO:0000949
name: aromatic amino acid family catabolic process to alcohol via Ehrlich pathway
namespace: biological_process
def: "The chemical reactions and pathways involving the catabolism of aromatic amino acids to produce aromatic alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When an aromatic family amino acid, phenylalanine, tyrosine, or tryptophan, is used as the substrate, 2-phenylethanol, 4-hydroxyphenylethanol, or tryptophol, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols." [GOC:krc, PMID:18281432]
is_a: GO:0000947 ! amino acid catabolic process to alcohol via Ehrlich pathway
is_a: GO:0009074 ! aromatic amino acid family catabolic process

[Term]
id: GO:0000950
name: branched-chain amino acid catabolic process to alcohol via Ehrlich pathway
namespace: biological_process
def: "The chemical reactions and pathways involving the catabolism of branched chain amino acids to produce branched chain alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When a branched chain family amino acid, leucine, isoleucine, or valine, is used as the substrate, 3-methylbutanol, 2-methylbutanol, or 2-methylpropanol, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols." [GOC:krc, PMID:18281432]
synonym: "branched chain family amino acid catabolic process to alcohol via Ehrlich pathway" EXACT [GOC:krc]
is_a: GO:0000947 ! amino acid catabolic process to alcohol via Ehrlich pathway
is_a: GO:0009083 ! branched-chain amino acid catabolic process

[Term]
id: GO:0000951
name: methionine catabolic process to 3-methylthiopropanol
namespace: biological_process
def: "The chemical reactions and pathways involving the catabolism of branched chain amino acids to produce branched chain alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When methionine is used as the substrate, 3-methylthiopropanol is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols." [GOC:krc, PMID:18281432]
is_a: GO:0000947 ! amino acid catabolic process to alcohol via Ehrlich pathway
is_a: GO:0009087 ! methionine catabolic process
is_a: GO:0044272 ! sulfur compound biosynthetic process

[Term]
id: GO:0000952
name: aromatic amino acid family catabolic process to carboxylic acid via Ehrlich pathway
namespace: biological_process
def: "The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When an aromatic family amino acid, phenylalanine, tyrosine, or tryptophan, is used as the substrate, 2-phenylethanoate, 4-hydroxyphenylethanoate, or 2-(Indol-3-yl)-ethanoate, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids." [GOC:krc, PMID:18281432]
is_a: GO:0000948 ! amino acid catabolic process to carboxylic acid via Ehrlich pathway
is_a: GO:0009074 ! aromatic amino acid family catabolic process

[Term]
id: GO:0000953
name: branched-chain amino acid catabolic process to carboxylic acid via Ehrlich pathway
namespace: biological_process
def: "The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When a branched chain family amino acid, leucine, isoleucine, or valine, is used as the substrate, 3-methylbutanoate, 2-methylbutanoate, or 2-methylpropanoate, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids." [GOC:krc, PMID:18281432]
synonym: "branched chain family amino acid catabolic process to carboxylic acid via Ehrlich pathway" EXACT [GOC:krc]
is_a: GO:0000948 ! amino acid catabolic process to carboxylic acid via Ehrlich pathway
is_a: GO:0009083 ! branched-chain amino acid catabolic process

[Term]
id: GO:0000954
name: methionine catabolic process to 3-methylthiopropanoate
namespace: biological_process
def: "The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When methionine is used as the substrate, 3-methylthiopropanoate is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids." [GOC:krc, PMID:18281432]
is_a: GO:0000948 ! amino acid catabolic process to carboxylic acid via Ehrlich pathway
is_a: GO:0006633 ! fatty acid biosynthetic process
is_a: GO:0009087 ! methionine catabolic process
is_a: GO:0044272 ! sulfur compound biosynthetic process

[Term]
id: GO:0000955
name: amino acid catabolic process via Ehrlich pathway
namespace: biological_process
def: "The chemical reactions and pathways involving the catabolism of amino acids to produce alcohols or carboxylic acids containing one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives, sometimes referred to as fusel acids, may be produced instead of alcohols." [GOC:krc, PMID:18281432]
is_a: GO:0009063 ! cellular amino acid catabolic process

[Term]
id: GO:0000956
name: nuclear-transcribed mRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells." [GOC:krc]
synonym: "nuclear mRNA breakdown" EXACT []
synonym: "nuclear mRNA catabolism" EXACT []
synonym: "nuclear mRNA degradation" EXACT []
is_a: GO:0006402 ! mRNA catabolic process

[Term]
id: GO:0000957
name: mitochondrial RNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of RNA transcribed from the mitochondrial genome and occurring in the mitochondrion." [GOC:krc, GOC:mah]
is_a: GO:0000959 ! mitochondrial RNA metabolic process
is_a: GO:0006401 ! RNA catabolic process
intersection_of: GO:0006401 ! RNA catabolic process
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion

[Term]
id: GO:0000958
name: mitochondrial mRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of mRNA transcribed from the mitochondrial genome and occurring in the mitochondrion." [GOC:krc, GOC:mah]
is_a: GO:0000957 ! mitochondrial RNA catabolic process
is_a: GO:0006402 ! mRNA catabolic process
intersection_of: GO:0006402 ! mRNA catabolic process
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion

[Term]
id: GO:0000959
name: mitochondrial RNA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving RNA transcribed from the mitochondrial genome and occurring in the mitochondrion." [GOC:krc, GOC:mah]
is_a: GO:0016070 ! RNA metabolic process
intersection_of: GO:0016070 ! RNA metabolic process
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion

[Term]
id: GO:0000960
name: regulation of mitochondrial RNA catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome." [GOC:krc, GOC:mah]
is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:0051252 ! regulation of RNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000957 ! mitochondrial RNA catabolic process
relationship: regulates GO:0000957 ! mitochondrial RNA catabolic process

[Term]
id: GO:0000961
name: negative regulation of mitochondrial RNA catabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome." [GOC:krc, GOC:mah]
is_a: GO:0000960 ! regulation of mitochondrial RNA catabolic process
is_a: GO:1902369 ! negative regulation of RNA catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000957 ! mitochondrial RNA catabolic process
relationship: negatively_regulates GO:0000957 ! mitochondrial RNA catabolic process

[Term]
id: GO:0000962
name: positive regulation of mitochondrial RNA catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome." [GOC:krc, GOC:mah]
is_a: GO:0000960 ! regulation of mitochondrial RNA catabolic process
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:0051254 ! positive regulation of RNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000957 ! mitochondrial RNA catabolic process
relationship: positively_regulates GO:0000957 ! mitochondrial RNA catabolic process

[Term]
id: GO:0000963
name: mitochondrial RNA processing
namespace: biological_process
def: "The conversion of a primary RNA molecule transcribed from a mitochondrial genome into one or more mature RNA molecules; occurs in the mitochondrion." [GOC:krc, GOC:mah]
is_a: GO:0000959 ! mitochondrial RNA metabolic process
is_a: GO:0006396 ! RNA processing
is_a: GO:0007005 ! mitochondrion organization
is_a: GO:0044710 ! single-organism metabolic process
is_a: GO:1902589 ! single-organism organelle organization
intersection_of: GO:0006396 ! RNA processing
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion

[Term]
id: GO:0000964
name: mitochondrial RNA 5'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 5' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion." [GOC:krc, GOC:mah]
synonym: "mitochondrial RNA 5' end processing" RELATED []
is_a: GO:0000963 ! mitochondrial RNA processing
is_a: GO:0000966 ! RNA 5'-end processing
intersection_of: GO:0000966 ! RNA 5'-end processing
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion

[Term]
id: GO:0000965
name: mitochondrial RNA 3'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 3' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion." [GOC:krc, GOC:mah]
synonym: "mitochondrial RNA 3' end processing" RELATED []
is_a: GO:0000963 ! mitochondrial RNA processing
is_a: GO:0031123 ! RNA 3'-end processing
intersection_of: GO:0031123 ! RNA 3'-end processing
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion

[Term]
id: GO:0000966
name: RNA 5'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 5' end of an RNA molecule." [GOC:krc]
synonym: "RNA 5' end processing" EXACT []
is_a: GO:0006396 ! RNA processing

[Term]
id: GO:0000967
name: rRNA 5'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 5' end of an rRNA molecule." [GOC:krc]
synonym: "rRNA 5' end processing" EXACT []
is_a: GO:0006364 ! rRNA processing
is_a: GO:0034471 ! ncRNA 5'-end processing

[Term]
id: GO:0000968
name: tRNA exon ligation
namespace: biological_process
def: "An RNA exon ligation process that rejoins two exons of a pre-tRNA which has had the intron removed." [GOC:krc]
is_a: GO:0000378 ! RNA exon ligation
relationship: part_of GO:0006388 ! tRNA splicing, via endonucleolytic cleavage and ligation
created_by: kchris
creation_date: 2009-04-28T10:22:40Z

[Term]
id: GO:0000969
name: tRNA exon ligation utilizing ATP as source of linkage phosphate
namespace: biological_process
def: "A tRNA exon ligation process in which the splice junction phosphate is derived from exogenous ATP. This type of ligation to rejoin the 5' and 3' exons of a tRNA is observed in vertebrate species." [GOC:krc, PMID:17786051]
is_a: GO:0000968 ! tRNA exon ligation
created_by: kchris
creation_date: 2009-04-28T10:29:37Z

[Term]
id: GO:0000970
name: tRNA exon ligation utilizing GTP as source of linkage phosphate
namespace: biological_process
def: "A tRNA exon ligation process in which the splice junction phosphate is derived from exogenous GTP. This type of ligation to rejoin the 5' and 3' exons of a tRNA is observed in the yeast Saccharomyces cerevisiae where the ligation reaction also produces a 2'-phosphate at the splice junction which is subsequently removed as part of the ligation process." [GOC:krc, PMID:18217203, PMID:9299409]
is_a: GO:0000968 ! tRNA exon ligation
created_by: kchris
creation_date: 2009-04-28T10:33:25Z

[Term]
id: GO:0000971
name: tRNA exon ligation utilizing 2',3' cyclic phosphate of 5'-exon as source of linkage phosphate
namespace: biological_process
def: "A tRNA exon ligation process in which the splice junction phosphate is derived from the 2',3' cyclic phosphate at the 3'-end of the 5'-exon. This type of ligation to rejoin the 5' and 3' exons of a tRNA is observed in wheat, Chlamydomonas, and vertebrate species including humans." [GOC:krc, PMID:17786051, PMID:18217203, PMID:9299409]
is_a: GO:0000968 ! tRNA exon ligation
created_by: kchris
creation_date: 2009-04-28T10:36:17Z

[Term]
id: GO:0000972
name: transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery
namespace: biological_process
def: "The chromosome organization process in which the DNA sequence containing a gene transcribed by RNA polymerase II is maintained in a specific location at the nuclear periphery. In S. cerevisiae, this process involves cis-acting DNA sequences such as the TATA box and upstream activating sequence (UAS) elements, trans-acting transcriptional activators, and also the 3'-UTR of the transcript." [GOC:krc, PMID:18614049]
is_a: GO:0051276 ! chromosome organization
created_by: kchris
creation_date: 2009-09-10T12:25:11Z

[Term]
id: GO:0000973
name: posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery
namespace: biological_process
def: "The chromosome organization process in which the DNA sequence containing a gene transcribed by RNA polymerase II is maintained in a specific location at the nuclear periphery even after transcription has been repressed." [GOC:krc, PMID:17373856, PMID:18614049]
is_a: GO:0000972 ! transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery
created_by: kchris
creation_date: 2009-09-10T12:28:04Z

[Term]
id: GO:0000974
name: Prp19 complex
namespace: cellular_component
def: "A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p." [GOC:krc, PMID:16540691, PMID:19239890]
synonym: "nineteen complex" NARROW []
synonym: "NTC" RELATED []
synonym: "Prp19/CDC5 complex" NARROW []
is_a: GO:0043234 ! protein complex
created_by: kchris
creation_date: 2009-10-12T10:01:30Z

[Term]
id: GO:0000975
name: regulatory region DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a DNA region that regulates a DNA-based process. Such processes include transcription, DNA replication, and DNA repair." [GOC:txnOH]
is_a: GO:0001067 ! regulatory region nucleic acid binding
is_a: GO:0003677 ! DNA binding
created_by: kchris
creation_date: 2010-08-10T10:56:24Z

[Term]
id: GO:0000976
name: transcription regulatory region sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]
comment: The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding".
is_a: GO:0044212 ! transcription regulatory region DNA binding
is_a: GO:1990837 ! sequence-specific double-stranded DNA binding
created_by: kchris
creation_date: 2010-08-10T11:00:02Z

[Term]
id: GO:0000977
name: RNA polymerase II regulatory region sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH]
comment: The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding".
is_a: GO:0000976 ! transcription regulatory region sequence-specific DNA binding
is_a: GO:0001012 ! RNA polymerase II regulatory region DNA binding
created_by: kchris
creation_date: 2010-08-10T11:05:36Z

[Term]
id: GO:0000978
name: RNA polymerase II core promoter proximal region sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II." [GOC:txnOH]
comment: Note that the phrase "upstream activating sequence", or UAS is often used in S. cerevisiae literature to refer to regulatory sequences that occur in the region upstream and proximal to the core promoter. In contrast, in bacteria such as E. coli, the phrase "upstream activating sequence", or UAS is a synonym for "enhancer".
synonym: "RNA polymerase II upstream activating sequence (UAS) sequence-specific DNA binding" RELATED []
is_a: GO:0000977 ! RNA polymerase II regulatory region sequence-specific DNA binding
is_a: GO:0000987 ! core promoter proximal region sequence-specific DNA binding
created_by: kchris
creation_date: 2010-08-10T02:17:19Z

[Term]
id: GO:0000979
name: RNA polymerase II core promoter sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase II basal transcription machinery." [GOC:txnOH]
is_a: GO:0000977 ! RNA polymerase II regulatory region sequence-specific DNA binding
is_a: GO:0001046 ! core promoter sequence-specific DNA binding
created_by: kchris
creation_date: 2010-08-10T02:17:28Z

[Term]
id: GO:0000980
name: RNA polymerase II distal enhancer sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter." [GOC:txnOH]
comment: Note that distal enhancers of the type found in mammalian cells are not known to occur in either Saccharomyces cerevisiae or Schizosaccharomyces pombe. While some S. cerevisiae literature does refer to sequences distal to the initiation site, these distal sites do not seem to function independently of position or orientation as mammalian distal enhancers do and are not considered to be enhancers.
is_a: GO:0000977 ! RNA polymerase II regulatory region sequence-specific DNA binding
is_a: GO:0001158 ! enhancer sequence-specific DNA binding
created_by: kchris
creation_date: 2010-08-10T02:29:25Z

[Term]
id: GO:0000981
name: RNA polymerase II transcription factor activity, sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH]
synonym: "sequence-specific DNA binding RNA polymerase II transcription factor activity" EXACT []
is_a: GO:0003700 ! transcription factor activity, sequence-specific DNA binding
relationship: has_part GO:0000977 ! RNA polymerase II regulatory region sequence-specific DNA binding
relationship: part_of GO:0006357 ! regulation of transcription from RNA polymerase II promoter
created_by: kchris
creation_date: 2010-08-10T02:37:21Z

[Term]
id: GO:0000982
name: transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II." [GOC:txnOH]
synonym: "RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity" EXACT []
is_a: GO:0000981 ! RNA polymerase II transcription factor activity, sequence-specific DNA binding
relationship: has_part GO:0000978 ! RNA polymerase II core promoter proximal region sequence-specific DNA binding
created_by: kchris
creation_date: 2010-08-10T02:39:46Z

[Term]
id: GO:0000983
name: transcription factor activity, RNA polymerase II core promoter sequence-specific
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific DNA sequence in an RNA polymerase II (Pol II) core promoter, the region composed of the transcription start site and binding sites for transcription factors of the Pol II basal transcription machinery, in order to modulate transcription by Pol II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH]
synonym: "RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity" EXACT []
is_a: GO:0000981 ! RNA polymerase II transcription factor activity, sequence-specific DNA binding
relationship: has_part GO:0000979 ! RNA polymerase II core promoter sequence-specific DNA binding
created_by: kchris
creation_date: 2010-08-10T02:47:56Z

[Term]
id: GO:0000984
name: bacterial-type RNA polymerase regulatory region sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is part of a regulatory region that controls the transcription of a gene or operon by a bacterial-type RNA polymerase." [GOC:txnOH]
comment: The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding".
subset: gosubset_prok
synonym: "eubacterial-type RNA polymerase regulatory region sequence-specific DNA binding" RELATED []
is_a: GO:0000976 ! transcription regulatory region sequence-specific DNA binding
is_a: GO:0001017 ! bacterial-type RNA polymerase regulatory region DNA binding
created_by: kchris
creation_date: 2010-08-10T02:58:18Z

[Term]
id: GO:0000985
name: bacterial-type RNA polymerase core promoter sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific DNA sequence in a bacterial-type RNA polymerase core promoter, the region composed of the transcription start site and binding sites for transcription factors of the basal transcription machinery, in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH]
subset: gosubset_prok
synonym: "eubacterial-type RNA polymerase core promoter sequence-specific DNA binding" EXACT []
is_a: GO:0000984 ! bacterial-type RNA polymerase regulatory region sequence-specific DNA binding
is_a: GO:0001046 ! core promoter sequence-specific DNA binding
created_by: kchris
creation_date: 2010-08-10T03:01:38Z

[Term]
id: GO:0000986
name: bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for a bacterial-type RNA polymerase." [GOC:txnOH]
subset: gosubset_prok
synonym: "eubacterial-type RNA polymerase regulatory transcription factor sequence-specific DNA binding" EXACT []
is_a: GO:0000984 ! bacterial-type RNA polymerase regulatory region sequence-specific DNA binding
is_a: GO:0000987 ! core promoter proximal region sequence-specific DNA binding
created_by: kchris
creation_date: 2010-08-10T03:02:31Z

[Term]
id: GO:0000987
name: core promoter proximal region sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to the core promoter. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]
comment: The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding".
is_a: GO:0000976 ! transcription regulatory region sequence-specific DNA binding
is_a: GO:0001159 ! core promoter proximal region DNA binding
created_by: kchris
creation_date: 2010-08-10T03:40:16Z

[Term]
id: GO:0000988
name: transcription factor activity, protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. This term does not provide specificity with respect to the type of protein binding, e.g. transcription factor binding or RNA polymerase binding. Please use a child term that provides that specificity or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_yeast
synonym: "protein binding transcription factor activity" EXACT []
synonym: "transcription factor activity" BROAD []
is_a: GO:0003674 ! molecular_function
intersection_of: GO:0003674 ! molecular_function
intersection_of: has_part GO:0005515 ! protein binding
intersection_of: part_of GO:1903506 ! regulation of nucleic acid-templated transcription
relationship: has_part GO:0005515 ! protein binding
relationship: part_of GO:1903506 ! regulation of nucleic acid-templated transcription
created_by: kchris
creation_date: 2010-08-10T04:03:22Z

[Term]
id: GO:0000989
name: transcription factor activity, transcription factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH]
synonym: "transcription factor binding transcription factor activity" EXACT []
is_a: GO:0000988 ! transcription factor activity, protein binding
intersection_of: GO:0003674 ! molecular_function
intersection_of: has_part GO:0008134 ! transcription factor binding
intersection_of: regulates GO:0097659 ! nucleic acid-templated transcription
relationship: has_part GO:0008134 ! transcription factor binding
relationship: regulates GO:0097659 ! nucleic acid-templated transcription
created_by: kchris
creation_date: 2010-08-10T04:57:43Z

[Term]
id: GO:0000990
name: transcription factor activity, core RNA polymerase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH]
synonym: "core RNA polymerase binding transcription factor activity" EXACT []
is_a: GO:0000988 ! transcription factor activity, protein binding
intersection_of: GO:0003674 ! molecular_function
intersection_of: has_part GO:0043175 ! RNA polymerase core enzyme binding
intersection_of: part_of GO:1903506 ! regulation of nucleic acid-templated transcription
relationship: has_part GO:0043175 ! RNA polymerase core enzyme binding
relationship: part_of GO:1903506 ! regulation of nucleic acid-templated transcription
created_by: kchris
creation_date: 2010-08-10T05:01:03Z

[Term]
id: GO:0000991
name: transcription factor activity, core RNA polymerase II binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase II (Pol II) complex, typically composed of twelve subunits, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH]
synonym: "core RNA polymerase II binding transcription factor activity" EXACT []
is_a: GO:0000990 ! transcription factor activity, core RNA polymerase binding
intersection_of: GO:0003674 ! molecular_function
intersection_of: has_part GO:0000993 ! RNA polymerase II core binding
intersection_of: part_of GO:0006357 ! regulation of transcription from RNA polymerase II promoter
relationship: has_part GO:0000993 ! RNA polymerase II core binding
relationship: part_of GO:0006357 ! regulation of transcription from RNA polymerase II promoter
created_by: kchris
creation_date: 2010-08-10T05:03:45Z

[Term]
id: GO:0000992
name: polymerase III regulatory region sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is part of a regulatory region that controls transcription by RNA polymerase III. The transcribed region might be contain a single gene or a cistron containing multiple genes." [GOC:txnOH, PMID:12381659]
comment: The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding".
is_a: GO:0000976 ! transcription regulatory region sequence-specific DNA binding
is_a: GO:0001016 ! RNA polymerase III regulatory region DNA binding
created_by: kchris
creation_date: 2010-08-11T03:49:28Z

[Term]
id: GO:0000993
name: RNA polymerase II core binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits." [GOC:txnOH]
is_a: GO:0001099 ! basal RNA polymerase II transcription machinery binding
is_a: GO:0032403 ! protein complex binding
is_a: GO:0043175 ! RNA polymerase core enzyme binding
created_by: kchris
creation_date: 2010-08-11T03:57:27Z

[Term]
id: GO:0000994
name: RNA polymerase III core binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with RNA polymerase III core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits." [GOC:txnOH]
is_a: GO:0043175 ! RNA polymerase core enzyme binding
created_by: kchris
creation_date: 2010-08-11T03:58:58Z

[Term]
id: GO:0000995
name: transcription factor activity, core RNA polymerase III binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH, PMID:12381659]
synonym: "core RNA polymerase III binding transcription factor activity" EXACT []
is_a: GO:0000990 ! transcription factor activity, core RNA polymerase binding
intersection_of: GO:0003674 ! molecular_function
intersection_of: has_part GO:0000994 ! RNA polymerase III core binding
intersection_of: part_of GO:0006359 ! regulation of transcription from RNA polymerase III promoter
relationship: has_part GO:0000994 ! RNA polymerase III core binding
relationship: part_of GO:0006359 ! regulation of transcription from RNA polymerase III promoter
created_by: kchris
creation_date: 2010-08-11T03:59:13Z

[Term]
id: GO:0000996
name: core DNA-dependent RNA polymerase binding promoter specificity activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with a DNA-dependent core RNA polymerase to form a holoenzyme complex and also, while present in the holoenzyme, interacting with promoter sequences in order to confer sequence specific recognition of promoter DNA sequence motifs." [GOC:txnOH]
is_a: GO:0000990 ! transcription factor activity, core RNA polymerase binding
intersection_of: GO:0003674 ! molecular_function
intersection_of: has_part GO:0000976 ! transcription regulatory region sequence-specific DNA binding
intersection_of: has_part GO:0043175 ! RNA polymerase core enzyme binding
intersection_of: part_of GO:0006355 ! regulation of transcription, DNA-templated
relationship: has_part GO:0000976 ! transcription regulatory region sequence-specific DNA binding
relationship: has_part GO:0043175 ! RNA polymerase core enzyme binding
relationship: part_of GO:0006355 ! regulation of transcription, DNA-templated
created_by: kchris
creation_date: 2010-08-11T04:12:24Z

[Term]
id: GO:0000997
name: mitochondrial RNA polymerase core promoter sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is part of the core promoter for the mitochondrial RNA polymerase." [GOC:txnOH]
is_a: GO:0001044 ! mitochondrial RNA polymerase regulatory region sequence-specific DNA binding
is_a: GO:0001046 ! core promoter sequence-specific DNA binding
created_by: kchris
creation_date: 2010-08-17T04:48:40Z

[Term]
id: GO:0000999
name: RNA polymerase III type 1 promoter transcriptional preinitiation complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins on a type 1 RNA polymerase III (Pol III) promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is the first step of transcription. Type 1 promoters require TFIIIA for promoter recognition, which then recruits TFIIIC. TFIIIC in turn recruits TFIIIB, which recruits Pol III to the promoter." [GOC:txnOH, PMID:12381659]
is_a: GO:0070898 ! RNA polymerase III transcriptional preinitiation complex assembly
relationship: part_of GO:0001022 ! transcription initiation from RNA polymerase III type 1 promoter
created_by: kchris
creation_date: 2010-08-19T04:16:04Z

[Term]
id: GO:0001000
name: bacterial-type RNA polymerase core enzyme binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the bacterial-type RNA polymerase core enzyme, typically consisting of two alpha, one beta, one beta prime, and one omega subunit." [GOC:txnOH]
comment: Should omega be included here?
subset: gosubset_prok
synonym: "eubacterial-type RNA polymerase core enzyme binding" EXACT []
is_a: GO:0043175 ! RNA polymerase core enzyme binding
created_by: kchris
creation_date: 2010-08-17T04:59:00Z

[Term]
id: GO:0001001
name: mitochondrial single-subunit type RNA polymerase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a single subunit mitochondrial RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6." [GOC:txnOH, PMID:20701995, PMID:2088182]
is_a: GO:0001050 ! single-subunit type RNA polymerase binding
created_by: kchris
creation_date: 2010-08-17T05:01:28Z

[Term]
id: GO:0001002
name: RNA polymerase III type 1 promoter sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is a part of a type 1 promoter that controls transcription by RNA polymerase III. Type 1 promoters are found in 5S rRNA genes, downstream of the transcription start site within the sequence of the mature RNA, and require TFIIIA for recognition." [GOC:txnOH, PMID:12381659]
is_a: GO:0000992 ! polymerase III regulatory region sequence-specific DNA binding
is_a: GO:0001030 ! RNA polymerase III type 1 promoter DNA binding
created_by: kchris
creation_date: 2010-08-18T05:38:20Z

[Term]
id: GO:0001003
name: RNA polymerase III type 2 promoter sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is a part of a type 2 promoter that controls transcription by RNA polymerase III. Type 2 promoters consist of an A box and a B box downstream of the transcription start site within the sequence within the sequence of the mature RNA. Type 2 promoters are found in many tRNA genes as well as in other small RNAs." [GOC:txnOH, PMID:12381659]
is_a: GO:0000992 ! polymerase III regulatory region sequence-specific DNA binding
is_a: GO:0001031 ! RNA polymerase III type 2 promoter DNA binding
created_by: kchris
creation_date: 2010-08-18T05:51:18Z

[Term]
id: GO:0001004
name: transcription factor activity, RNA polymerase III promoter sequence-specific binding, TFIIIB recruiting
namespace: molecular_function
def: "The function of binding to a specific DNA sequence motif in an RNA polymerase III (Pol III) promoter in order to recruit the Pol III recruiting factor TFIIIB to the promoter." [GOC:txnOH, PMID:12381659]
synonym: "RNA polymerase III promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity" EXACT []
is_a: GO:0001010 ! transcription factor activity, sequence-specific DNA binding transcription factor recruiting
is_a: GO:0001034 ! RNA polymerase III transcription factor activity, sequence-specific DNA binding
is_a: GO:0001153 ! transcription factor activity, RNA polymerase III transcription factor recruiting
relationship: has_part GO:0000992 ! polymerase III regulatory region sequence-specific DNA binding
relationship: has_part GO:0001154 ! TFIIIB-class transcription factor binding
created_by: kchris
creation_date: 2010-08-18T05:53:32Z

[Term]
id: GO:0001005
name: transcription factor activity, RNA polymerase III type 1 promoter sequence-specific binding, TFIIIB recruiting
namespace: molecular_function
def: "The function of binding to a specific DNA sequence motif in a type 1 RNA polymerase III (Pol III) promoter in order to recruit the Pol III recruiting factor TFIIIB to the promoter. For type 1 Pol III promoters, this requires both TFIIIA and TFIIIC." [GOC:txnOH, PMID:12381659]
comment: This represents TFIIIA.
synonym: "RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity" EXACT []
synonym: "TFIIIA activity" RELATED []
synonym: "TFIIIC-type activity" RELATED []
is_a: GO:0001004 ! transcription factor activity, RNA polymerase III promoter sequence-specific binding, TFIIIB recruiting
relationship: has_part GO:0001002 ! RNA polymerase III type 1 promoter sequence-specific DNA binding
relationship: part_of GO:0000999 ! RNA polymerase III type 1 promoter transcriptional preinitiation complex assembly
created_by: kchris
creation_date: 2010-08-18T05:57:29Z

[Term]
id: GO:0001006
name: RNA polymerase III type 3 promoter sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is a part of a type 3 promoter that controls transcription by RNA polymerase III (Pol III). A type 3 Pol III promoter is composed of elements upstream of the transcription start site, including a TATA box. The human U6 snRNA gene has a type 3 promoter. Type 3 Pol III promoters have not been observed in S. cerevisiae." [GOC:txnOH, PMID:12381659]
is_a: GO:0000992 ! polymerase III regulatory region sequence-specific DNA binding
is_a: GO:0001032 ! RNA polymerase III type 3 promoter DNA binding
created_by: kchris
creation_date: 2010-08-18T06:02:26Z

[Term]
id: GO:0001007
name: transcription factor activity, RNA polymerase III transcription factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase III transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH]
synonym: "RNA polymerase III transcription factor binding transcription factor activity" EXACT []
is_a: GO:0000989 ! transcription factor activity, transcription factor binding
relationship: has_part GO:0001025 ! RNA polymerase III transcription factor binding
relationship: part_of GO:0006359 ! regulation of transcription from RNA polymerase III promoter
created_by: kchris
creation_date: 2010-08-18T06:24:07Z

[Term]
id: GO:0001008
name: transcription factor activity, RNA polymerase III type 2 promoter sequence-specific binding, TFIIIB recruiting
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific DNA sequence motif in a type 2 RNA polymerase III (Pol III) promoter in order to recruit TFIIIB to the promoter. For type 2 Pol III promoters, this requires TFIIIC activity." [GOC:txnOH, PMID:12381659]
synonym: "RNA polymerase III type 2 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity" EXACT []
synonym: "TFIIIC-type activity" RELATED []
synonym: "type 2 RNA polymerase III promoter recognition" EXACT []
is_a: GO:0001004 ! transcription factor activity, RNA polymerase III promoter sequence-specific binding, TFIIIB recruiting
relationship: has_part GO:0001003 ! RNA polymerase III type 2 promoter sequence-specific DNA binding
relationship: part_of GO:0001021 ! RNA polymerase III type 2 promoter transcriptional preinitiation complex assembly
created_by: kchris
creation_date: 2010-08-18T06:30:45Z

[Term]
id: GO:0001009
name: transcription from RNA polymerase III type 2 promoter
namespace: biological_process
def: "The synthesis of RNA from a DNA template by RNA polymerase III (RNAP III), originating at a type 2 RNAP III promoter. Type 2 RNAP III promoters consist of an A box and a B box downstream of the transcription start site within the sequence of the mature RNA and the process of initiation is different than from other promoter types. Type 2 promoters are found in many tRNA genes as well as in other small RNAs." [GOC:txnOH, PMID:12381659]
is_a: GO:0006383 ! transcription from RNA polymerase III promoter
created_by: kchris
creation_date: 2010-08-18T06:37:56Z

[Term]
id: GO:0001010
name: transcription factor activity, sequence-specific DNA binding transcription factor recruiting
namespace: molecular_function
def: "The function of binding to a specific DNA sequence and recruiting another transcription factor to the DNA in order to modulate transcription. The recruited factor may bind DNA directly, or may be colocalized via protein-protein interactions." [GOC:txnOH]
synonym: "sequence-specific DNA binding transcription factor recruiting transcription factor activity" EXACT []
is_a: GO:0001134 ! transcription factor activity, transcription factor recruiting
is_a: GO:0003700 ! transcription factor activity, sequence-specific DNA binding
created_by: kchris
creation_date: 2010-08-18T06:46:33Z

[Term]
id: GO:0001011
name: transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific DNA sequence and recruiting RNA polymerase to the DNA in order to form the preinitiation complex (PIC)." [GOC:txnOH]
synonym: "sequence-specific DNA binding RNA polymerase recruiting transcription factor activity" EXACT []
is_a: GO:0003700 ! transcription factor activity, sequence-specific DNA binding
created_by: kchris
creation_date: 2010-08-18T06:49:16Z

[Term]
id: GO:0001012
name: RNA polymerase II regulatory region DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a DNA region that controls the transcription of a region of DNA by RNA polymerase II. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH, GOC:vw]
is_a: GO:0044212 ! transcription regulatory region DNA binding
created_by: kchris
creation_date: 2010-08-19T09:43:58Z

[Term]
id: GO:0001013
name: RNA polymerase I regulatory region DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a DNA region that controls the transcription of a region of DNA by RNA polymerase I. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH, GOC:vw]
is_a: GO:0044212 ! transcription regulatory region DNA binding
created_by: kchris
creation_date: 2010-08-19T09:44:02Z

[Term]
id: GO:0001014
name: snoRNA transcription from a type 2 RNA polymerase III promoter
namespace: biological_process
def: "The synthesis of small nucleolar RNA (snoRNA) from a DNA template by RNA polymerase III, originating at a type 2 RNA polymerase III promoter." [GOC:txnOH]
is_a: GO:0001009 ! transcription from RNA polymerase III type 2 promoter
is_a: GO:0009302 ! snoRNA transcription
created_by: kchris
creation_date: 2010-08-18T07:13:45Z

[Term]
id: GO:0001015
name: snoRNA transcription from an RNA polymerase II promoter
namespace: biological_process
def: "The synthesis of small nucleolar RNA (snoRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter." [GOC:txnOH]
is_a: GO:0006366 ! transcription from RNA polymerase II promoter
is_a: GO:0009302 ! snoRNA transcription
created_by: kchris
creation_date: 2010-08-18T07:21:18Z

[Term]
id: GO:0001016
name: RNA polymerase III regulatory region DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a DNA region that controls the transcription of a gene by RNA polymerase III. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH, GOC:vw, PMID:12381659]
is_a: GO:0044212 ! transcription regulatory region DNA binding
created_by: kchris
creation_date: 2010-08-19T09:36:17Z

[Term]
id: GO:0001017
name: bacterial-type RNA polymerase regulatory region DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a DNA region that controls the transcription of a gene or operon by a bacterial-type RNA polymerase. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH]
subset: gosubset_prok
synonym: "eubacterial-type RNA polymerase regulatory region DNA binding" EXACT []
is_a: GO:0044212 ! transcription regulatory region DNA binding
created_by: kchris
creation_date: 2010-08-19T09:45:42Z

[Term]
id: GO:0001018
name: mitochondrial RNA polymerase regulatory region DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a DNA region that controls the transcription of a region of DNA by mitochondrial RNA polymerase. Binding may occur as a high affinity and sequence specific interaction or as a lower affinity interaction observed once a factor has been recruited to the DNA by other factors." [GOC:txnOH, GOC:vw, PMID:20056105]
is_a: GO:0044212 ! transcription regulatory region DNA binding
created_by: kchris
creation_date: 2010-08-19T09:46:22Z

[Term]
id: GO:0001019
name: plastid RNA polymerase regulatory region DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a DNA region that controls the transcription of a region of DNA by a plastid RNA polymerase. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH, GOC:vw]
is_a: GO:0044212 ! transcription regulatory region DNA binding
created_by: kchris
creation_date: 2010-08-19T09:46:27Z

[Term]
id: GO:0001020
name: RNA polymerase III type 3 promoter transcriptional preinitiation complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins on a type 1 RNA polymerase III (Pol III) promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is the first step of transcription." [GOC:txnOH, PMID:12381659]
is_a: GO:0070898 ! RNA polymerase III transcriptional preinitiation complex assembly
relationship: part_of GO:0001024 ! transcription initiation from RNA polymerase III type 3 promoter
created_by: kchris
creation_date: 2010-08-19T04:18:46Z

[Term]
id: GO:0001021
name: RNA polymerase III type 2 promoter transcriptional preinitiation complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins on a type 2 RNA polymerase III (Pol III) promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is the first step of transcription. Type 2 promoters require TFIIIC for promoter recognition, which then recruits TFIIIB, which in turn which recruits Pol III to the promoter." [GOC:txnOH, PMID:12381659]
is_a: GO:0070898 ! RNA polymerase III transcriptional preinitiation complex assembly
relationship: part_of GO:0001023 ! transcription initiation from RNA polymerase III type 2 promoter
created_by: kchris
creation_date: 2010-08-19T04:18:53Z

[Term]
id: GO:0001022
name: transcription initiation from RNA polymerase III type 1 promoter
namespace: biological_process
def: "A transcription initiation process on a type 1 RNA polymerase III (Pol III) that results in RNA synthesis by Pol III. Type 1 promoters are found in 5S rRNA genes, downstream of the transcription start site within the sequence of the mature RNA, and require TFIIIA for recognition." [GOC:txnOH, PMID:12381659]
is_a: GO:0006384 ! transcription initiation from RNA polymerase III promoter
relationship: part_of GO:0042791 ! 5S class rRNA transcription from RNA polymerase III type 1 promoter
created_by: kchris
creation_date: 2010-08-19T04:33:52Z

[Term]
id: GO:0001023
name: transcription initiation from RNA polymerase III type 2 promoter
namespace: biological_process
def: "A transcription initiation process on a type 2 RNA polymerase III (Pol III) that results in RNA synthesis by Pol III. Type 2 promoters consist of an A box and a B box downstream of the transcription start site within the sequence within the sequence of the mature RNA. Type 2 promoters are found in many tRNA genes as well as in other small RNAs." [GOC:txnOH, PMID:12381659]
is_a: GO:0006384 ! transcription initiation from RNA polymerase III promoter
relationship: part_of GO:0001009 ! transcription from RNA polymerase III type 2 promoter
created_by: kchris
creation_date: 2010-08-19T04:35:09Z

[Term]
id: GO:0001024
name: transcription initiation from RNA polymerase III type 3 promoter
namespace: biological_process
def: "A transcription initiation process on a type 3 RNA polymerase III (Pol III) that results in RNA synthesis by Pol III. A type 3 Pol III promoter is composed of elements upstream of the transcription start site, including a TATA box. The human U6 snRNA gene has a type 3 promoter. Type 3 Pol III promoters have not been observed in S. cerevisiae." [GOC:txnOH, PMID:12381659]
is_a: GO:0006384 ! transcription initiation from RNA polymerase III promoter
relationship: part_of GO:0001035 ! transcription from RNA polymerase III type 3 promoter
created_by: kchris
creation_date: 2010-08-19T04:35:14Z

[Term]
id: GO:0001025
name: RNA polymerase III transcription factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase III transcription factor, any protein required to initiate or regulate transcription by RNA polymerase III." [GOC:txnOH]
is_a: GO:0008134 ! transcription factor binding
created_by: kchris
creation_date: 2010-08-20T03:26:50Z

[Term]
id: GO:0001026
name: TFIIIB-type transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way, Once recruited to an RNA polymerase III promoter by one or more other transcription factors, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex." [GOC:txnOH]
synonym: "RNA polymerase III recruiting transcription factor activity" EXACT []
is_a: GO:0000995 ! transcription factor activity, core RNA polymerase III binding
is_a: GO:0001007 ! transcription factor activity, RNA polymerase III transcription factor binding
relationship: has_part GO:0001016 ! RNA polymerase III regulatory region DNA binding
created_by: kchris
creation_date: 2010-08-23T12:24:31Z

[Term]
id: GO:0001027
name: RNA polymerase III type 1 promoter TFIIIB-type transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way. Once recruited to an RNA polymerase III type 1 promoter by TFIIIA-type and TFIIIC-type factors, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex." [GOC:txnOH, PMID:12381659]
synonym: "RNA polymerase III type 1 promoter polymerase recruiting transcription factor activity" RELATED []
is_a: GO:0001026 ! TFIIIB-type transcription factor activity
relationship: has_part GO:0001030 ! RNA polymerase III type 1 promoter DNA binding
relationship: part_of GO:0000999 ! RNA polymerase III type 1 promoter transcriptional preinitiation complex assembly
created_by: kchris
creation_date: 2010-08-23T12:50:20Z

[Term]
id: GO:0001028
name: RNA polymerase III type 2 promoter TFIIIB-type transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way. Once recruited to an RNA polymerase III type 2 promoter by a TFIIIC-type factor, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex." [GOC:txnOH, PMID:12381659]
synonym: "RNA polymerase III type 2 promoter polymerase recruiting transcription factor activity" RELATED []
is_a: GO:0001026 ! TFIIIB-type transcription factor activity
relationship: has_part GO:0001031 ! RNA polymerase III type 2 promoter DNA binding
relationship: part_of GO:0001021 ! RNA polymerase III type 2 promoter transcriptional preinitiation complex assembly
created_by: kchris
creation_date: 2010-08-23T12:52:01Z

[Term]
id: GO:0001029
name: RNA polymerase III type 3 promoter TFIIIB-type transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way. Once recruited to an RNA polymerase III type 3 promoter by SNAP-type and TFIIIC-type factors, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex." [GOC:txnOH, PMID:12381659]
synonym: "RNA polymerase III type 3 promoter polymerase recruiting transcription factor activity" RELATED []
is_a: GO:0001026 ! TFIIIB-type transcription factor activity
relationship: has_part GO:0001032 ! RNA polymerase III type 3 promoter DNA binding
relationship: part_of GO:0001020 ! RNA polymerase III type 3 promoter transcriptional preinitiation complex assembly
created_by: kchris
creation_date: 2010-08-23T12:52:40Z

[Term]
id: GO:0001030
name: RNA polymerase III type 1 promoter DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a region of DNA that is a part of a type 1 promoter that controls transcription by RNA polymerase III. Type 1 promoters are found in 5S rRNA genes, downstream of the transcription start site within the sequence of the mature RNA, and require TFIIIA for recognition." [GOC:txnOH, PMID:12381659]
is_a: GO:0001016 ! RNA polymerase III regulatory region DNA binding
is_a: GO:0080084 ! 5S rDNA binding
created_by: kchris
creation_date: 2010-08-23T12:58:54Z

[Term]
id: GO:0001031
name: RNA polymerase III type 2 promoter DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a region of DNA that is a part of a type 2 promoter that controls transcription by RNA polymerase III. Type 2 promoters consist of an A box and a B box downstream of the transcription start site within the sequence within the sequence of the mature RNA. Type 2 promoters are found in many tRNA genes as well as in other small RNAs." [GOC:txnOH, PMID:12381659]
is_a: GO:0001016 ! RNA polymerase III regulatory region DNA binding
created_by: kchris
creation_date: 2010-08-23T01:14:56Z

[Term]
id: GO:0001032
name: RNA polymerase III type 3 promoter DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a region of DNA that is a part of a type 3 promoter that controls transcription by RNA polymerase III. A type 3 Pol III promoter is composed of elements upstream of the transcription start site, including a TATA box. The human U6 snRNA gene has a type 3 promoter. Type 3 Pol III promoters have not been observed in S. cerevisiae." [GOC:txnOH, PMID:12381659]
is_a: GO:0001016 ! RNA polymerase III regulatory region DNA binding
created_by: kchris
creation_date: 2010-08-23T01:15:14Z

[Term]
id: GO:0001033
name: transcription factor activity, RNA polymerase III type 3 promoter TFIIIB recruiting
namespace: molecular_function
def: "The function of binding to a specific DNA sequence motif in a type 3 RNA polymerase III (Pol III) promoter in order to recruit TFIIIB to the promoter. For type 3 Pol III promoters, this requires SNAPc activity." [GOC:txnOH, PMID:12381659]
comment: This represents TFIIIC.
synonym: "RNA polymerase III type 3 promoter TFIIIB recruiting transcription factor activity" EXACT []
synonym: "SNAPc-type activity" RELATED []
synonym: "type 3 RNA polymerase III promoter recognition" EXACT []
is_a: GO:0001004 ! transcription factor activity, RNA polymerase III promoter sequence-specific binding, TFIIIB recruiting
relationship: has_part GO:0001006 ! RNA polymerase III type 3 promoter sequence-specific DNA binding
relationship: part_of GO:0001020 ! RNA polymerase III type 3 promoter transcriptional preinitiation complex assembly
created_by: kchris
creation_date: 2010-08-23T03:04:17Z

[Term]
id: GO:0001034
name: RNA polymerase III transcription factor activity, sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase III. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH, PMID:12381659]
synonym: "sequence-specific DNA binding RNA polymerase III transcription factor activity" EXACT []
is_a: GO:0003700 ! transcription factor activity, sequence-specific DNA binding
relationship: part_of GO:0006359 ! regulation of transcription from RNA polymerase III promoter
created_by: kchris
creation_date: 2010-08-23T03:41:48Z

[Term]
id: GO:0001035
name: transcription from RNA polymerase III type 3 promoter
namespace: biological_process
def: "The synthesis of RNA from a DNA template by RNA polymerase III (RNAP III), originating at a type 3 RNAP III promoter. A type 3 RNAP III promoter is composed of elements upstream of the transcription start site, including a TATA box and the process of initiation is different than from other promoter types. The human U6 snRNA gene has a type 3 promoter. Type 3 Pol III promoters have not been observed in S. cerevisiae." [GOC:txnOH, PMID:12381659]
synonym: "U6 snRNA transcription (mammalian)" NARROW []
is_a: GO:0006383 ! transcription from RNA polymerase III promoter
created_by: kchris
creation_date: 2010-08-23T04:17:41Z

[Term]
id: GO:0001036
name: transcription initiation from RNA polymerase III hybrid type promoter
namespace: biological_process
def: "A transcription initiation process on a hybrid type RNA polymerase III (Pol III) that results in RNA synthesis by Pol III (Pol III). A hybrid Pol III promoter contains both regulatory elements both upstream and downstream of the transcription initiation site. An example gene with such a promoter is the S. cerevisiae U6 gene." [GOC:txnOH, PMID:12381659]
is_a: GO:0006384 ! transcription initiation from RNA polymerase III promoter
relationship: part_of GO:0001041 ! transcription from a RNA polymerase III hybrid type promoter
created_by: kchris
creation_date: 2010-08-23T06:08:55Z

[Term]
id: GO:0001037
name: RNA polymerase III hybrid type promoter DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a region of DNA that is a part of a hybrid promoter that controls transcription by RNA polymerase III (Pol III). A hybrid Pol III promoter contains both regulatory elements both upstream and downstream of the transcription initiation site. An example gene with such a promoter is the S. cerevisiae U6 gene." [GOC:txnOH, PMID:12381659]
is_a: GO:0001016 ! RNA polymerase III regulatory region DNA binding
created_by: kchris
creation_date: 2010-08-24T02:51:34Z

[Term]
id: GO:0001038
name: RNA polymerase III hybrid type promoter TFIIIB recruiting transcription factor activity
namespace: molecular_function
def: "Once recruited to an RNA polymerase III hybrid type promoter by sequence-specific DNA binding transcription factors, direct DNA binding, or a combination of both, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex." [GOC:txnOH, PMID:12381659]
is_a: GO:0001004 ! transcription factor activity, RNA polymerase III promoter sequence-specific binding, TFIIIB recruiting
relationship: has_part GO:0001039 ! RNA polymerase III hybrid type promoter sequence-specific DNA binding
relationship: part_of GO:0001043 ! RNA polymerase III hybrid type promoter transcriptional preinitiation complex assembly
created_by: kchris
creation_date: 2010-08-23T06:17:33Z

[Term]
id: GO:0001039
name: RNA polymerase III hybrid type promoter sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is a part of a hybrid type promoter that controls transcription by RNA polymerase III (Pol III). A hybrid Pol III promoter contains both regulatory elements both upstream and downstream of the transcription initiation site. An example gene with such a promoter is the S. cerevisiae U6 gene." [GOC:txnOH, PMID:12381659]
is_a: GO:0000992 ! polymerase III regulatory region sequence-specific DNA binding
is_a: GO:0001037 ! RNA polymerase III hybrid type promoter DNA binding
created_by: kchris
creation_date: 2010-08-23T06:21:24Z

[Term]
id: GO:0001040
name: RNA polymerase III hybrid type promoter TFIIIB-type transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way. Once recruited to an RNA polymerase III hybrid type promoter, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex." [GOC:txnOH, PMID:12381659]
is_a: GO:0001026 ! TFIIIB-type transcription factor activity
relationship: has_part GO:0001037 ! RNA polymerase III hybrid type promoter DNA binding
relationship: part_of GO:0001043 ! RNA polymerase III hybrid type promoter transcriptional preinitiation complex assembly
created_by: kchris
creation_date: 2010-08-23T06:28:23Z

[Term]
id: GO:0001041
name: transcription from a RNA polymerase III hybrid type promoter
namespace: biological_process
def: "The synthesis of RNA from a DNA template by RNA polymerase III, originating at a hybrid type RNA polymerase III (RNAP III) promoter. A hybrid RNAP III promoter contains both regulatory elements both upstream and downstream of the transcription initiation site. An example gene with such a promoter is the S. cerevisiae U6 gene." [GOC:txnOH, PMID:12381659]
synonym: "U2 snRNA transcription (S. cerevisiae)" NARROW []
is_a: GO:0006383 ! transcription from RNA polymerase III promoter
created_by: kchris
creation_date: 2010-08-24T02:11:52Z

[Term]
id: GO:0001042
name: RNA polymerase I core binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with RNA polymerase I core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits." [GOC:txnOH]
is_a: GO:0043175 ! RNA polymerase core enzyme binding
created_by: kchris
creation_date: 2010-09-23T01:39:23Z

[Term]
id: GO:0001043
name: RNA polymerase III hybrid type promoter transcriptional preinitiation complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins on a hybrid type RNA polymerase III (Pol III) promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is the first step of transcription. Hybrid type promoters contain both gene-internal and upstream elements. An example of a hybrid promoter is the U6 snRNA gene." [GOC:txnOH, PMID:12381659]
is_a: GO:0070898 ! RNA polymerase III transcriptional preinitiation complex assembly
created_by: kchris
creation_date: 2010-08-24T02:19:52Z

[Term]
id: GO:0001044
name: mitochondrial RNA polymerase regulatory region sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific sequence of DNA that controls the transcription of a region of DNA by mitochondrial RNA polymerase." [GOC:txnOH]
comment: The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding".
is_a: GO:0000976 ! transcription regulatory region sequence-specific DNA binding
is_a: GO:0001018 ! mitochondrial RNA polymerase regulatory region DNA binding
created_by: kchris
creation_date: 2010-08-25T04:11:49Z

[Term]
id: GO:0001045
name: mitochondrial RNA polymerase core promoter proximal region sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for a mitochondrial RNA polymerase." [GOC:txnOH, PMID:20670382]
is_a: GO:0000987 ! core promoter proximal region sequence-specific DNA binding
is_a: GO:0001044 ! mitochondrial RNA polymerase regulatory region sequence-specific DNA binding
created_by: kchris
creation_date: 2010-08-25T04:13:36Z

[Term]
id: GO:0001046
name: core promoter sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is part of a core promoter region composed of the transcription start site and binding sites for the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]
comment: The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding".
is_a: GO:0000976 ! transcription regulatory region sequence-specific DNA binding
is_a: GO:0001047 ! core promoter binding
created_by: kchris
creation_date: 2010-08-25T04:17:44Z

[Term]
id: GO:0001047
name: core promoter binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for the basal transcription machinery. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH]
is_a: GO:0044212 ! transcription regulatory region DNA binding
created_by: kchris
creation_date: 2010-08-27T03:00:52Z

[Term]
id: GO:0001048
name: RNA polymerase IV core binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with RNA polymerase IV core enzyme, a multisubunit eukaryotic nuclear RNA polymerase found in plants and involved in siRNA production." [GOC:txnOH, PMID:19110459]
is_a: GO:0043175 ! RNA polymerase core enzyme binding
created_by: kchris
creation_date: 2010-09-23T01:41:03Z

[Term]
id: GO:0001049
name: RNA polymerase V core binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with RNA polymerase V core enzyme, a multisubunit eukaryotic nuclear RNA polymerase found in plants and involved in production of noncoding transcripts at target loci for silencing." [GOC:txnOH, PMID:19110459]
is_a: GO:0043175 ! RNA polymerase core enzyme binding
created_by: kchris
creation_date: 2010-09-23T01:41:08Z

[Term]
id: GO:0001050
name: single-subunit type RNA polymerase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a single subunit RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6." [GOC:txnOH, PMID:20701995]
synonym: "SP6-type RNA polymerase binding" EXACT []
synonym: "T3-type RNA polymerase binding" EXACT []
synonym: "T3/T7 type RNA polymerase binding" EXACT []
synonym: "T7-type RNA polymerase binding" EXACT []
is_a: GO:0070063 ! RNA polymerase binding
created_by: kchris
creation_date: 2010-09-23T02:33:45Z

[Term]
id: GO:0001051
name: plastid single-subunit type RNA polymerase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a single subunit plastid RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6." [GOC:txnOH, PMID:20701995]
is_a: GO:0001050 ! single-subunit type RNA polymerase binding
created_by: kchris
creation_date: 2010-09-23T02:42:57Z

[Term]
id: GO:0001052
name: plastid PEP RNA polymerase core enzyme binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the bacterial-type plastid PEP RNA polymerase core enzyme, typically consisting of two alpha, one beta, one beta prime, and one double prime subunit." [GOC:txnOH, PMID:20701995]
is_a: GO:0001000 ! bacterial-type RNA polymerase core enzyme binding
created_by: kchris
creation_date: 2010-09-23T02:49:31Z

[Term]
id: GO:0001053
name: plastid sigma factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with a plastid PEP core RNA polymerase to form a holoenzyme complex and also, while present in the holoenzyme, interacting with promoter sequences in order to confer sequence specific recognition of plastid PEP core promoter DNA sequence motifs." [GOC:txnOH, PMID:20701995]
subset: gosubset_prok
synonym: "sigma transcription factor" RELATED []
is_a: GO:0016987 ! sigma factor activity
relationship: has_part GO:0001052 ! plastid PEP RNA polymerase core enzyme binding
created_by: kchris
creation_date: 2010-09-23T03:03:00Z

[Term]
id: GO:0001054
name: RNA polymerase I activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase I specific promoter to direct initiation and catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH]
synonym: "DNA-directed RNA polymerase activity involved in transcription from RNA polymerase I promoter" EXACT []
is_a: GO:0003899 ! DNA-directed RNA polymerase activity
intersection_of: GO:0003899 ! DNA-directed RNA polymerase activity
intersection_of: part_of GO:0006360 ! transcription from RNA polymerase I promoter
relationship: part_of GO:0006360 ! transcription from RNA polymerase I promoter
created_by: kchris
creation_date: 2010-09-23T03:36:11Z

[Term]
id: GO:0001055
name: RNA polymerase II activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH]
synonym: "DNA-directed RNA polymerase activity involved in transcription from RNA polymerase II promoter" EXACT []
is_a: GO:0003899 ! DNA-directed RNA polymerase activity
intersection_of: GO:0003899 ! DNA-directed RNA polymerase activity
intersection_of: part_of GO:0006366 ! transcription from RNA polymerase II promoter
relationship: part_of GO:0006366 ! transcription from RNA polymerase II promoter
created_by: kchris
creation_date: 2010-09-23T03:44:23Z

[Term]
id: GO:0001056
name: RNA polymerase III activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase III specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH]
synonym: "DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter" EXACT []
is_a: GO:0003899 ! DNA-directed RNA polymerase activity
intersection_of: GO:0003899 ! DNA-directed RNA polymerase activity
intersection_of: part_of GO:0006383 ! transcription from RNA polymerase III promoter
relationship: part_of GO:0006383 ! transcription from RNA polymerase III promoter
created_by: kchris
creation_date: 2010-09-23T03:44:47Z

[Term]
id: GO:0001057
name: RNA polymerase IV activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase IV specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH]
synonym: "DNA-directed RNA polymerase activity involved in transcription from RNA polymerase IV promoter" EXACT []
is_a: GO:0003899 ! DNA-directed RNA polymerase activity
intersection_of: GO:0003899 ! DNA-directed RNA polymerase activity
intersection_of: part_of GO:0001059 ! transcription from RNA polymerase IV promoter
relationship: part_of GO:0001059 ! transcription from RNA polymerase IV promoter
created_by: kchris
creation_date: 2010-09-23T03:44:55Z

[Term]
id: GO:0001058
name: RNA polymerase V activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase V specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH]
synonym: "DNA-directed RNA polymerase activity involved in transcription from RNA polymerase V promoter" EXACT []
is_a: GO:0003899 ! DNA-directed RNA polymerase activity
intersection_of: GO:0003899 ! DNA-directed RNA polymerase activity
intersection_of: part_of GO:0001060 ! transcription from RNA polymerase V promoter
relationship: part_of GO:0001060 ! transcription from RNA polymerase V promoter
created_by: kchris
creation_date: 2010-09-23T03:45:01Z

[Term]
id: GO:0001059
name: transcription from RNA polymerase IV promoter
namespace: biological_process
def: "The synthesis of RNA from a DNA template by RNA polymerase IV (Pol III), originating at a Pol IV-specific promoter." [GOC:txnOH, PMID:19110459]
synonym: "transcription from RNA pol IV promoter" EXACT []
is_a: GO:0006351 ! transcription, DNA-templated
created_by: kchris
creation_date: 2010-09-23T03:51:35Z

[Term]
id: GO:0001060
name: transcription from RNA polymerase V promoter
namespace: biological_process
def: "The synthesis of RNA from a DNA template by RNA polymerase V (Pol III), originating at a Pol V-specific promoter." [GOC:txnOH, PMID:19110459]
synonym: "transcription from RNA pol V promoter" EXACT []
is_a: GO:0006351 ! transcription, DNA-templated
created_by: kchris
creation_date: 2010-09-23T03:54:04Z

[Term]
id: GO:0001061
name: bacterial-type RNA polymerase activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a bacterial-type specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH]
is_a: GO:0003899 ! DNA-directed RNA polymerase activity
relationship: part_of GO:0001121 ! transcription from bacterial-type RNA polymerase promoter
created_by: kchris
creation_date: 2010-10-19T03:36:01Z

[Term]
id: GO:0001062
name: plastid PEP-A RNA polymerase activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a plastid PEP-A RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH, PMID:20701995]
is_a: GO:0001061 ! bacterial-type RNA polymerase activity
relationship: part_of GO:0042793 ! transcription from plastid promoter
created_by: kchris
creation_date: 2010-10-19T03:38:49Z

[Term]
id: GO:0001063
name: plastid PEP-B RNA polymerase activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a plastid PEP-B RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH, PMID:20701995]
is_a: GO:0001061 ! bacterial-type RNA polymerase activity
relationship: part_of GO:0042793 ! transcription from plastid promoter
created_by: kchris
creation_date: 2010-10-19T03:46:46Z

[Term]
id: GO:0001064
name: single subunit type RNA polymerase activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single-subunit-type RNA polymerase-specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH]
synonym: "T3/T7 type RNA polymerase activity" EXACT []
is_a: GO:0003899 ! DNA-directed RNA polymerase activity
created_by: kchris
creation_date: 2010-10-19T03:47:56Z

[Term]
id: GO:0001065
name: mitochondrial single subunit type RNA polymerase activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single-subunit-type mitochondrial RNA polymerase-specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH]
is_a: GO:0001064 ! single subunit type RNA polymerase activity
relationship: part_of GO:0006390 ! transcription from mitochondrial promoter
created_by: kchris
creation_date: 2010-10-19T03:50:51Z

[Term]
id: GO:0001066
name: plastid single subunit type RNA polymerase activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single subunit type plastid RNA polymerase specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH, PMID:20701995]
is_a: GO:0001064 ! single subunit type RNA polymerase activity
relationship: part_of GO:0042793 ! transcription from plastid promoter
created_by: kchris
creation_date: 2010-10-19T03:54:57Z

[Term]
id: GO:0001067
name: regulatory region nucleic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a nucleic acid region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair." [GOC:txnOH]
is_a: GO:0003676 ! nucleic acid binding
created_by: kchris
creation_date: 2010-10-21T04:08:56Z

[Term]
id: GO:0001068
name: transcription regulatory region RNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a RNA region within the transcript that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon." [GOC:txnOH]
is_a: GO:0001069 ! regulatory region RNA binding
created_by: kchris
creation_date: 2010-10-21T04:15:32Z

[Term]
id: GO:0001069
name: regulatory region RNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a RNA region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair." [GOC:txnOH]
is_a: GO:0001067 ! regulatory region nucleic acid binding
is_a: GO:0003723 ! RNA binding
created_by: kchris
creation_date: 2010-10-21T04:17:01Z

[Term]
id: GO:0001070
name: RNA binding transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH, PMID:8332211]
synonym: "transcription factor activity" BROAD []
is_a: GO:0001071 ! nucleic acid binding transcription factor activity
relationship: has_part GO:0001068 ! transcription regulatory region RNA binding
created_by: kchris
creation_date: 2010-10-21T04:19:17Z

[Term]
id: GO:0001071
name: nucleic acid binding transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with a DNA or RNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. This term does not provide specificity with respect to the type of nucleic acid binding, e.g. RNA or DNA. Please use a child term that provides that specificity or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_yeast
synonym: "transcription factor activity" BROAD []
is_a: GO:0003674 ! molecular_function
relationship: has_part GO:0003676 ! nucleic acid binding
relationship: part_of GO:2001141 ! regulation of RNA biosynthetic process
created_by: kchris
creation_date: 2010-10-21T04:37:54Z

[Term]
id: GO:0001072
name: transcription antitermination factor activity, RNA binding
namespace: molecular_function
def: "Binds to RNA, typically within the nascent RNA transcript, to promote readthrough of a transcription termination site and thus extending the length of the RNA transcript produced. Examples of antitermination factors which bind the nascent RNA include the lambda N protein and the HIV-1 tat protein." [GOC:txnOH, PMID:8332211]
subset: gosubset_prok
synonym: "RNA binding transcription antitermination factor activity" EXACT []
is_a: GO:0001070 ! RNA binding transcription factor activity
relationship: part_of GO:0031564 ! transcription antitermination
created_by: kchris
creation_date: 2010-10-21T04:48:17Z

[Term]
id: GO:0001073
name: transcription antitermination factor activity, DNA binding
namespace: molecular_function
def: "Binds to DNA, typically within region of the promoter and transcribed region, to promote readthrough of a transcription termination site and thus extending the length of the RNA transcript produced. Examples of antitermination factors which bind DNA include the lambda Q protein." [GOC:txnOH, PMID:8332211]
subset: gosubset_prok
synonym: "DNA binding transcription antitermination factor activity" EXACT []
is_a: GO:0003700 ! transcription factor activity, sequence-specific DNA binding
relationship: part_of GO:0031564 ! transcription antitermination
created_by: kchris
creation_date: 2010-10-21T05:18:52Z

[Term]
id: GO:0001074
name: transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding involved in preinitiation complex assembly
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to promote assembly of the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase II promoter." [GOC:txnOH]
synonym: "RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly" EXACT []
is_a: GO:0000982 ! transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
relationship: part_of GO:0051123 ! RNA polymerase II transcriptional preinitiation complex assembly
created_by: kchris
creation_date: 2010-10-22T02:30:43Z

[Term]
id: GO:0001075
name: transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific DNA sequence in an RNA polymerase II (Pol II) core promoter, the region composed of the transcription start site and binding sites for transcription factors of the Pol II basal transcription machinery, in order to promote assembly of the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase II promoter." [GOC:txnOH]
synonym: "RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly" EXACT []
synonym: "sequence-specific core promoter binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly" EXACT []
is_a: GO:0000983 ! transcription factor activity, RNA polymerase II core promoter sequence-specific
relationship: part_of GO:0051123 ! RNA polymerase II transcriptional preinitiation complex assembly
created_by: kchris
creation_date: 2010-10-22T02:35:51Z

[Term]
id: GO:0001076
name: transcription factor activity, RNA polymerase II transcription factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH]
synonym: "RNA polymerase II transcription factor binding transcription factor activity" EXACT []
is_a: GO:0000989 ! transcription factor activity, transcription factor binding
intersection_of: GO:0000988 ! transcription factor activity, protein binding
intersection_of: has_part GO:0001085 ! RNA polymerase II transcription factor binding
relationship: has_part GO:0001085 ! RNA polymerase II transcription factor binding
relationship: part_of GO:0006357 ! regulation of transcription from RNA polymerase II promoter
created_by: kchris
creation_date: 2010-10-22T02:49:32Z

[Term]
id: GO:0001077
name: transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter." [GOC:txnOH]
synonym: "RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription" EXACT []
is_a: GO:0000982 ! transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
is_a: GO:0001228 ! transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
created_by: kchris
creation_date: 2010-10-26T03:40:43Z

[Term]
id: GO:0001078
name: transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:txnOH]
synonym: "RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription" EXACT []
is_a: GO:0000982 ! transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
is_a: GO:0001227 ! transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
created_by: kchris
creation_date: 2010-10-26T03:56:48Z

[Term]
id: GO:0001079
name: nitrogen catabolite regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A transcription regulation process in which the presence of one nitrogen source leads to the modulation of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources." [GOC:mah, GOC:txnOH, PMID:19104072]
synonym: "regulation of transcription from RNA polymerase II promoter by nitrogen catabolites" EXACT [GOC:mah]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0090293 ! nitrogen catabolite regulation of transcription
created_by: kchris
creation_date: 2010-10-27T03:29:01Z

[Term]
id: GO:0001080
name: nitrogen catabolite activation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A transcription regulation process in which the presence of one nitrogen source leads to an increase in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources." [GOC:mah, GOC:txnOH, PMID:19104072]
synonym: "positive regulation of transcription from RNA polymerase II promoter by nitrogen catabolites" EXACT [GOC:mah]
is_a: GO:0001079 ! nitrogen catabolite regulation of transcription from RNA polymerase II promoter
is_a: GO:0090294 ! nitrogen catabolite activation of transcription
created_by: kchris
creation_date: 2010-10-27T03:32:34Z

[Term]
id: GO:0001081
name: nitrogen catabolite repression of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A transcription regulation process in which the presence of one nitrogen source leads to a decrease in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources." [GOC:mah, GOC:txnOH, PMID:19104072]
synonym: "negative regulation of transcription from RNA polymerase II promoter by nitrogen catabolites" EXACT [GOC:mah]
is_a: GO:0001079 ! nitrogen catabolite regulation of transcription from RNA polymerase II promoter
is_a: GO:0090295 ! nitrogen catabolite repression of transcription
created_by: kchris
creation_date: 2010-10-27T03:38:05Z

[Term]
id: GO:0001082
name: transcription factor activity, RNA polymerase I transcription factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase I transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH]
synonym: "RNA polymerase I transcription factor binding transcription factor activity" EXACT []
is_a: GO:0000989 ! transcription factor activity, transcription factor binding
relationship: has_part GO:0001179 ! RNA polymerase I transcription factor binding
relationship: part_of GO:0006356 ! regulation of transcription from RNA polymerase I promoter
created_by: kchris
creation_date: 2010-10-27T04:03:47Z

[Term]
id: GO:0001083
name: transcription factor activity, RNA polymerase II basal transcription factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH]
synonym: "RNA polymerase II basal transcription factor binding transcription factor activity" EXACT []
is_a: GO:0001076 ! transcription factor activity, RNA polymerase II transcription factor binding
intersection_of: GO:0000988 ! transcription factor activity, protein binding
intersection_of: has_part GO:0001091 ! RNA polymerase II basal transcription factor binding
relationship: has_part GO:0001091 ! RNA polymerase II basal transcription factor binding
created_by: kchris
creation_date: 2010-10-27T04:12:55Z

[Term]
id: GO:0001084
name: transcription factor activity, TFIID-class binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIID class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH]
synonym: "TFIID-class binding transcription factor activity" EXACT []
is_a: GO:0001083 ! transcription factor activity, RNA polymerase II basal transcription factor binding
intersection_of: GO:0000988 ! transcription factor activity, protein binding
intersection_of: has_part GO:0001094 ! TFIID-class transcription factor binding
relationship: has_part GO:0001094 ! TFIID-class transcription factor binding
created_by: kchris
creation_date: 2010-10-27T04:15:22Z

[Term]
id: GO:0001085
name: RNA polymerase II transcription factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase II transcription factor, any protein required to initiate or regulate transcription by RNA polymerase II." [GOC:txnOH]
is_a: GO:0008134 ! transcription factor binding
created_by: kchris
creation_date: 2010-10-28T02:08:59Z

[Term]
id: GO:0001086
name: transcription factor activity, TFIIA-class binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIA class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH]
synonym: "TFIIA-class binding transcription factor activity" EXACT []
is_a: GO:0001083 ! transcription factor activity, RNA polymerase II basal transcription factor binding
intersection_of: GO:0000988 ! transcription factor activity, protein binding
intersection_of: has_part GO:0001092 ! TFIIA-class transcription factor binding
relationship: has_part GO:0001092 ! TFIIA-class transcription factor binding
created_by: kchris
creation_date: 2010-10-28T02:14:59Z

[Term]
id: GO:0001087
name: transcription factor activity, TFIIB-class binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIB class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH]
synonym: "TFIIB-class binding transcription factor activity" EXACT []
is_a: GO:0001083 ! transcription factor activity, RNA polymerase II basal transcription factor binding
intersection_of: GO:0000988 ! transcription factor activity, protein binding
intersection_of: has_part GO:0001093 ! TFIIB-class transcription factor binding
relationship: has_part GO:0001093 ! TFIIB-class transcription factor binding
created_by: kchris
creation_date: 2010-10-28T02:18:00Z

[Term]
id: GO:0001088
name: transcription factor activity, TFIIE-class binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIE class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH]
synonym: "TFIIE-class binding transcription factor activity" EXACT []
is_a: GO:0001083 ! transcription factor activity, RNA polymerase II basal transcription factor binding
intersection_of: GO:0000988 ! transcription factor activity, protein binding
intersection_of: has_part GO:0001095 ! TFIIE-class transcription factor binding
relationship: has_part GO:0001095 ! TFIIE-class transcription factor binding
created_by: kchris
creation_date: 2010-10-28T02:25:22Z

[Term]
id: GO:0001089
name: transcription factor activity, TFIIF-class transcription factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIF class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH]
synonym: "TFIIF-class binding transcription factor activity" EXACT []
is_a: GO:0001083 ! transcription factor activity, RNA polymerase II basal transcription factor binding
intersection_of: GO:0000988 ! transcription factor activity, protein binding
intersection_of: has_part GO:0001096 ! TFIIF-class transcription factor binding
relationship: has_part GO:0001096 ! TFIIF-class transcription factor binding
created_by: kchris
creation_date: 2010-10-28T02:27:12Z

[Term]
id: GO:0001090
name: transcription factor activity, TFIIH-class binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIH class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH]
synonym: "TFIIH-class binding transcription factor activity" EXACT []
is_a: GO:0001083 ! transcription factor activity, RNA polymerase II basal transcription factor binding
intersection_of: GO:0000988 ! transcription factor activity, protein binding
intersection_of: has_part GO:0001097 ! TFIIH-class transcription factor binding
relationship: has_part GO:0001097 ! TFIIH-class transcription factor binding
created_by: kchris
creation_date: 2010-10-28T02:28:01Z

[Term]
id: GO:0001091
name: RNA polymerase II basal transcription factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor, any of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor." [GOC:txnOH, PMID:16858867]
is_a: GO:0001085 ! RNA polymerase II transcription factor binding
is_a: GO:0001099 ! basal RNA polymerase II transcription machinery binding
created_by: kchris
creation_date: 2010-10-28T02:30:02Z

[Term]
id: GO:0001092
name: TFIIA-class transcription factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIA class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor." [GOC:krc, PMID:16858867]
is_a: GO:0001091 ! RNA polymerase II basal transcription factor binding
created_by: kchris
creation_date: 2010-10-28T02:37:19Z

[Term]
id: GO:0001093
name: TFIIB-class transcription factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIB class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor." [GOC:krc, PMID:16858867]
is_a: GO:0001091 ! RNA polymerase II basal transcription factor binding
created_by: kchris
creation_date: 2010-10-28T02:46:15Z

[Term]
id: GO:0001094
name: TFIID-class transcription factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIID class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor." [GOC:krc, PMID:16858867]
is_a: GO:0001091 ! RNA polymerase II basal transcription factor binding
created_by: kchris
creation_date: 2010-10-28T02:48:33Z

[Term]
id: GO:0001095
name: TFIIE-class transcription factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIE class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor." [GOC:krc, PMID:16858867]
is_a: GO:0001091 ! RNA polymerase II basal transcription factor binding
created_by: kchris
creation_date: 2010-10-28T02:49:20Z

[Term]
id: GO:0001096
name: TFIIF-class transcription factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIF class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor." [GOC:krc, PMID:16858867]
is_a: GO:0001091 ! RNA polymerase II basal transcription factor binding
created_by: kchris
creation_date: 2010-10-28T02:51:20Z

[Term]
id: GO:0001097
name: TFIIH-class transcription factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIH class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor." [GOC:krc, PMID:16858867]
is_a: GO:0001091 ! RNA polymerase II basal transcription factor binding
created_by: kchris
creation_date: 2010-10-28T02:51:41Z

[Term]
id: GO:0001098
name: basal transcription machinery binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the basal transcription machinery which is composed of the RNA polymerase core enzyme and the basal transcription factor(s), the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase." [GOC:txnOH]
comment: Note that the definition of basal, or general, transcription factors has typically been done at a small number of well characterized activator-independent promoters. At an activator-dependent promoter, one or more additional factors are generally required in addition to the basal factors.
is_a: GO:0005515 ! protein binding
created_by: kchris
creation_date: 2010-11-24T12:50:49Z

[Term]
id: GO:0001099
name: basal RNA polymerase II transcription machinery binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the basal transcription machinery for RNA polymerase II which is composed of the RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits, and the basal RNA polymerase II transcription factors, the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase." [GOC:txnOH]
comment: Note that the definition of basal, or general, transcription factors has typically been done at a small number of well characterized activator-independent promoters. At an activator-dependent promoter, one or more additional factors are generally required in addition to the basal factors.
is_a: GO:0001098 ! basal transcription machinery binding
created_by: kchris
creation_date: 2010-11-24T12:54:33Z

[Term]
id: GO:0001100
name: negative regulation of exit from mitosis
namespace: biological_process
def: "Any process involved in the inhibition of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity)." [GOC:rn]
synonym: "down regulation of exit from mitosis" EXACT []
synonym: "down-regulation of exit from mitosis" EXACT []
synonym: "downregulation of exit from mitosis" EXACT []
synonym: "inhibition of exit from mitosis" NARROW []
is_a: GO:0007096 ! regulation of exit from mitosis
is_a: GO:0045839 ! negative regulation of mitotic nuclear division
is_a: GO:1901991 ! negative regulation of mitotic cell cycle phase transition
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010458 ! exit from mitosis
relationship: negatively_regulates GO:0010458 ! exit from mitosis

[Term]
id: GO:0001101
name: response to acid chemical
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form." [GOC:go_curators, GOC:rn, http://en.wikipedia.org/wiki/Acid]
comment: This term should be used to describe a response to a specific acid as a chemical. E.g., if an organism were responding to glutamate, then the response would be glutamate-specific; the organism is actually responding to the chemical structure of the anion portion of the dissociated acid. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. If annotating experiments where an acid is playing a role as a proton donor, please annotate to GO:0010447 'response to acidic pH' instead.
subset: gocheck_do_not_manually_annotate
synonym: "response to acid" BROAD []
synonym: "response to acid anion" RELATED []
synonym: "response to oxoanion" RELATED []
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0001102
name: RNA polymerase II activating transcription factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription." [GOC:txnOH]
is_a: GO:0001085 ! RNA polymerase II transcription factor binding
is_a: GO:0033613 ! activating transcription factor binding
created_by: kchris
creation_date: 2010-11-24T02:17:08Z

[Term]
id: GO:0001103
name: RNA polymerase II repressing transcription factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase II transcription repressing factor, a protein involved in negative regulation of transcription." [GOC:txnOH]
is_a: GO:0001085 ! RNA polymerase II transcription factor binding
is_a: GO:0070491 ! repressing transcription factor binding
created_by: kchris
creation_date: 2010-11-24T02:34:55Z

[Term]
id: GO:0001104
name: RNA polymerase II transcription cofactor activity
namespace: molecular_function
alt_id: GO:0016455
def: "Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal RNAP II transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
subset: gosubset_prok
synonym: "RNA polymerase II transcription cofactor activity" EXACT []
synonym: "RNA polymerase II transcription mediator activity" RELATED []
synonym: "RNA polymerase II transcriptional co-regulator" EXACT []
synonym: "RNA polymerase II transcriptional cofactor activity" EXACT []
synonym: "thyroid receptor-associated protein" RELATED []
synonym: "TRAP protein" RELATED []
is_a: GO:0001076 ! transcription factor activity, RNA polymerase II transcription factor binding
is_a: GO:0003712 ! transcription cofactor activity
relationship: has_part GO:0001099 ! basal RNA polymerase II transcription machinery binding
created_by: kchris
creation_date: 2010-11-24T03:02:15Z

[Term]
id: GO:0001105
name: RNA polymerase II transcription coactivator activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between activating transcription factors and the basal RNAP II transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
comment: Note that some basal transcription factors are themselves considered to have coactivator activity, in that they mediate interactions between an activator and either RNA polymerase II itself or another basal transcription factor.
subset: gosubset_prok
synonym: "RNA polymerase II transcription co-activator activity" EXACT []
synonym: "RNA polymerase II transcription coactivator activity" EXACT []
is_a: GO:0001104 ! RNA polymerase II transcription cofactor activity
is_a: GO:0001190 ! transcriptional activator activity, RNA polymerase II transcription factor binding
is_a: GO:0003713 ! transcription coactivator activity
relationship: has_part GO:0001102 ! RNA polymerase II activating transcription factor binding
relationship: part_of GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
created_by: kchris
creation_date: 2010-11-24T03:08:19Z

[Term]
id: GO:0001106
name: RNA polymerase II transcription corepressor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase II repressing transcription factor and also with the RNA polymerase II basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
synonym: "RNA polymerase II transcription co-repressor activity" EXACT []
synonym: "RNA polymerase II transcription corepressor activity" EXACT []
is_a: GO:0001104 ! RNA polymerase II transcription cofactor activity
is_a: GO:0001191 ! transcriptional repressor activity, RNA polymerase II transcription factor binding
is_a: GO:0003714 ! transcription corepressor activity
relationship: has_part GO:0001103 ! RNA polymerase II repressing transcription factor binding
relationship: part_of GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
created_by: kchris
creation_date: 2010-11-24T03:14:44Z

[Term]
id: GO:0001108
name: bacterial-type RNA polymerase holo enzyme binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the basal transcription machinery which is composed of a bacterial-type RNA polymerase core enzyme and a sigma factor, the minimal set of factors required for formation of the preinitiation complex (PIC) by a bacterial-type RNA polymerase." [GOC:txnOH]
subset: gosubset_prok
synonym: "basal bacterial-type RNA polymerase transcription machinery binding" EXACT []
is_a: GO:0001098 ! basal transcription machinery binding
created_by: kchris
creation_date: 2010-11-30T04:26:04Z

[Term]
id: GO:0001109
name: promoter clearance during DNA-templated transcription
namespace: biological_process
def: "Any process involved in the transition from the initiation to the elongation phases of transcription by a DNA-dependent RNA polymerase, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors." [GOC:txnOH, PMID:15020047, PMID:18280161]
synonym: "promoter clearance during DNA-dependent transcription" EXACT [GOC:txnOH]
synonym: "promoter escape" BROAD []
is_a: GO:0032774 ! RNA biosynthetic process
relationship: has_part GO:0001119 ! protein-DNA-RNA complex remodeling
relationship: part_of GO:0006351 ! transcription, DNA-templated
created_by: kchris
creation_date: 2010-12-01T02:13:09Z

[Term]
id: GO:0001110
name: promoter clearance from RNA polymerase III promoter
namespace: biological_process
def: "Any process involved in the transition from the initiation to the elongation phases of transcription by RNA polymerase III, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase." [GOC:txnOH]
is_a: GO:0001109 ! promoter clearance during DNA-templated transcription
relationship: part_of GO:0006383 ! transcription from RNA polymerase III promoter
created_by: kchris
creation_date: 2010-12-01T03:08:29Z

[Term]
id: GO:0001111
name: promoter clearance from RNA polymerase II promoter
namespace: biological_process
def: "Any process involved in the transition from the initiation to the elongation phases of transcription by RNA polymerase II, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors." [GOC:txnOH, PMID:15020047]
synonym: "promoter escape from RNA polymerase II promoter" EXACT []
is_a: GO:0001109 ! promoter clearance during DNA-templated transcription
relationship: part_of GO:0006366 ! transcription from RNA polymerase II promoter
created_by: kchris
creation_date: 2010-12-01T03:09:31Z

[Term]
id: GO:0001112
name: DNA-templated transcriptional open complex formation
namespace: biological_process
def: "Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble." [GOC:txnOH, PMID:15020047, PMID:18280161]
synonym: "DNA-dependent transcriptional open complex formation" EXACT [GOC:txnOH]
synonym: "promoter melting" BROAD []
is_a: GO:0001120 ! protein-DNA complex remodeling
relationship: part_of GO:0006352 ! DNA-templated transcription, initiation
created_by: kchris
creation_date: 2010-12-02T02:15:04Z

[Term]
id: GO:0001113
name: transcriptional open complex formation at RNA polymerase II promoter
namespace: biological_process
def: "Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase II preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble." [GOC:txnOH, PMID:15020047, PMID:18280161]
synonym: "RNA polymerase II promoter melting" EXACT []
is_a: GO:0001112 ! DNA-templated transcriptional open complex formation
relationship: part_of GO:0006367 ! transcription initiation from RNA polymerase II promoter
created_by: kchris
creation_date: 2010-12-02T02:27:19Z

[Term]
id: GO:0001114
name: protein-DNA-RNA complex
namespace: cellular_component
def: "A macromolecular complex containing protein, DNA, and RNA molecules." [GOC:txnOH]
is_a: GO:0032991 ! macromolecular complex
created_by: kchris
creation_date: 2010-12-03T02:09:38Z

[Term]
id: GO:0001115
name: protein-DNA-RNA complex subunit organization
namespace: biological_process
def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA-RNA complex." [GOC:txnOH]
synonym: "protein-DNA-RNA complex subunit organisation" EXACT [GOC:mah]
is_a: GO:0043933 ! macromolecular complex subunit organization
created_by: kchris
creation_date: 2010-12-03T04:00:02Z

[Term]
id: GO:0001116
name: protein-DNA-RNA complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex." [GOC:txnOH]
is_a: GO:0001115 ! protein-DNA-RNA complex subunit organization
is_a: GO:0034622 ! cellular macromolecular complex assembly
created_by: kchris
creation_date: 2010-12-03T04:01:38Z

[Term]
id: GO:0001117
name: protein-DNA-RNA complex disassembly
namespace: biological_process
def: "The disaggregation of a protein-DNA-RNA complex into its constituent components." [GOC:txnOH]
is_a: GO:0001115 ! protein-DNA-RNA complex subunit organization
is_a: GO:0032984 ! macromolecular complex disassembly
created_by: kchris
creation_date: 2010-12-03T04:04:07Z

[Term]
id: GO:0001118
name: transcription ternary complex disassembly
namespace: biological_process
def: "The disaggregation of a transcription ternary complex, composed of RNA polymerase, template DNA, and an RNA transcript, into its constituent components." [GOC:txnOH]
synonym: "transcription protein-DNA-RNA complex disassembly" EXACT []
is_a: GO:0001117 ! protein-DNA-RNA complex disassembly
relationship: part_of GO:0006353 ! DNA-templated transcription, termination
created_by: kchris
creation_date: 2010-12-03T04:11:34Z

[Term]
id: GO:0001119
name: protein-DNA-RNA complex remodeling
namespace: biological_process
def: "The acquisition, loss, or modification of macromolecules within a complex, resulting in the alteration of an existing complex." [GOC:txnOH]
is_a: GO:0001115 ! protein-DNA-RNA complex subunit organization
is_a: GO:0034367 ! macromolecular complex remodeling
created_by: kchris
creation_date: 2010-12-03T04:15:52Z

[Term]
id: GO:0001120
name: protein-DNA complex remodeling
namespace: biological_process
def: "The acquisition, loss, or modification of macromolecules within a complex, resulting in the alteration of an existing complex." [GOC:txnOH]
is_a: GO:0034367 ! macromolecular complex remodeling
is_a: GO:0071824 ! protein-DNA complex subunit organization
created_by: kchris
creation_date: 2010-12-03T04:17:15Z

[Term]
id: GO:0001121
name: transcription from bacterial-type RNA polymerase promoter
namespace: biological_process
def: "The synthesis of RNA from a DNA template by a bacterial-type RNA polymerase, originating at a bacterial-type promoter." [GOC:txnOH]
is_a: GO:0006351 ! transcription, DNA-templated
created_by: kchris
creation_date: 2010-12-06T03:32:13Z

[Term]
id: GO:0001122
name: promoter clearance from bacterial-type RNA polymerase promoter
namespace: biological_process
def: "Any process involved in the transition from the initiation to the elongation phase of transcription by a bacterial-type RNA polymerase, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance generally involves dissociation of the sigma initiation factor." [GOC:txnOH, PMID:18280161]
is_a: GO:0001109 ! promoter clearance during DNA-templated transcription
relationship: part_of GO:0001121 ! transcription from bacterial-type RNA polymerase promoter
created_by: kchris
creation_date: 2010-12-06T03:38:10Z

[Term]
id: GO:0001123
name: transcription initiation from bacterial-type RNA polymerase promoter
namespace: biological_process
def: "Any process involved in the assembly of bacterial-type RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription." [GOC:txnOH, PMID:18280161]
is_a: GO:0006352 ! DNA-templated transcription, initiation
relationship: part_of GO:0001121 ! transcription from bacterial-type RNA polymerase promoter
created_by: kchris
creation_date: 2010-12-06T03:40:12Z

[Term]
id: GO:0001124
name: transcription elongation from bacterial-type RNA polymerase promoter
namespace: biological_process
def: "The extension of an RNA molecule after transcription initiation and promoter clearance at a bacterial-type RNA polymerase promoter by the addition of ribonucleotides catalyzed by a bacterial-type RNA polymerase." [GOC:txnOH, PMID:18280161]
synonym: "RNA elongation from bacterial-type RNA polymerase promoter" EXACT []
is_a: GO:0006354 ! DNA-templated transcription, elongation
relationship: part_of GO:0001121 ! transcription from bacterial-type RNA polymerase promoter
created_by: kchris
creation_date: 2010-12-06T03:46:27Z

[Term]
id: GO:0001125
name: transcription termination from bacterial-type RNA polymerase promoter
namespace: biological_process
def: "The process in which the synthesis of an RNA molecule by a bacterial-type RNA polymerase using a DNA template is completed." [GOC:txnOH, PMID:18280161]
is_a: GO:0006353 ! DNA-templated transcription, termination
relationship: part_of GO:0001121 ! transcription from bacterial-type RNA polymerase promoter
created_by: kchris
creation_date: 2010-12-06T03:47:43Z

[Term]
id: GO:0001126
name: bacterial-type RNA polymerase preinitiation complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins on a bacterial-type RNA polymerase promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase." [GOC:txnOH, PMID:18280161]
synonym: "bacterial-type RNA polymerase transcription PIC biosynthesis" EXACT []
synonym: "bacterial-type RNA polymerase transcription PIC formation" EXACT []
synonym: "bacterial-type RNA polymerase transcriptional preinitiation complex formation" EXACT []
is_a: GO:0070897 ! DNA-templated transcriptional preinitiation complex assembly
relationship: part_of GO:0001123 ! transcription initiation from bacterial-type RNA polymerase promoter
created_by: kchris
creation_date: 2010-12-06T03:54:45Z

[Term]
id: GO:0001127
name: transcriptional open complex formation at bacterial-type RNA polymerase promoter
namespace: biological_process
def: "Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase II preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble." [GOC:txnOH, PMID:18280161]
is_a: GO:0001112 ! DNA-templated transcriptional open complex formation
relationship: part_of GO:0001123 ! transcription initiation from bacterial-type RNA polymerase promoter
created_by: kchris
creation_date: 2010-12-06T04:04:16Z

[Term]
id: GO:0001128
name: RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to increase the frequency, rate or stability of the aggregation, arrangement and bonding together of proteins on RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC). Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between activating transcription factors and the basal RNAP II transcription machinery." [GOC:txnOH, PMID:16858867]
comment: Note that some basal transcription factors are themselves considered to have coactivator activity, in that they mediate interactions between an activator and either RNA polymerase II itself or another basal transcription factor.
synonym: "RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly" EXACT []
is_a: GO:0001105 ! RNA polymerase II transcription coactivator activity
relationship: part_of GO:0051123 ! RNA polymerase II transcriptional preinitiation complex assembly
created_by: kchris
creation_date: 2011-01-20T02:13:36Z

[Term]
id: GO:0001129
name: RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly
namespace: molecular_function
def: "Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs), to facilitate the aggregation, arrangement and bonding together of proteins on RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase." [GOC:txnOH, PMID:16858867]
comment: For example, both TFIIA as well as TFIIB interact with TBP bound to DNA to stabilize formation of the preinitiation complex.
synonym: "TATA-binding protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly" NARROW []
synonym: "TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly" EXACT []
is_a: GO:0001132 ! RNA polymerase II transcription factor activity, TBP-class protein binding
relationship: part_of GO:0051123 ! RNA polymerase II transcriptional preinitiation complex assembly
created_by: kchris
creation_date: 2011-01-20T02:53:35Z

[Term]
id: GO:0001130
name: bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by bacterial-type RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH]
synonym: "sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity" EXACT []
is_a: GO:0003700 ! transcription factor activity, sequence-specific DNA binding
relationship: has_part GO:0000984 ! bacterial-type RNA polymerase regulatory region sequence-specific DNA binding
created_by: kchris
creation_date: 2011-01-26T10:36:02Z

[Term]
id: GO:0001131
name: transcription factor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for a bacterial-type RNA polymerase in order to modulate transcription by bacterial-type RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH]
synonym: "bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity" EXACT []
is_a: GO:0001130 ! bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding
relationship: has_part GO:0000986 ! bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding
created_by: kchris
creation_date: 2011-01-26T10:50:37Z

[Term]
id: GO:0001132
name: RNA polymerase II transcription factor activity, TBP-class protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs), in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH, PMID:16858867]
synonym: "TATA-binding protein binding RNA polymerase II transcription factor activity" NARROW []
synonym: "TBP-class protein binding RNA polymerase II transcription factor activity" EXACT []
synonym: "TRF protein binding RNA polymerase II transcription factor activity" NARROW []
is_a: GO:0001083 ! transcription factor activity, RNA polymerase II basal transcription factor binding
relationship: has_part GO:0017025 ! TBP-class protein binding
created_by: kchris
creation_date: 2011-01-20T04:15:44Z

[Term]
id: GO:0001133
name: RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA by RNA polymerase II and recruiting another transcription factor to the DNA in order to modulate transcription by RNAP II." [GOC:txnOH, PMID:16858867]
synonym: "sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity" EXACT []
is_a: GO:0001010 ! transcription factor activity, sequence-specific DNA binding transcription factor recruiting
created_by: kchris
creation_date: 2011-01-20T04:40:20Z

[Term]
id: GO:0001134
name: transcription factor activity, transcription factor recruiting
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific transcription factor, which may be a single protein or a complex, and with another protein, macromolecule, or complex, recruiting that specific transcription factor to the transcription machinery complex and thus permitting those molecules to function in a coordinated way, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH, PMID:16858867]
synonym: "transcription factor recruiting transcription factor activity" EXACT []
is_a: GO:0000989 ! transcription factor activity, transcription factor binding
created_by: kchris
creation_date: 2011-01-20T04:57:59Z

[Term]
id: GO:0001135
name: transcription factor activity, RNA polymerase II transcription factor recruiting
namespace: molecular_function
def: "The function of binding to an RNA polymerase II (RNAP II) transcription factor and recruiting it to the transcription machinery complex in order to modulate transcription by RNAP II." [GOC:txnOH, PMID:16858867]
synonym: "RNA polymerase II transcription factor recruiting transcription factor activity" EXACT []
is_a: GO:0001076 ! transcription factor activity, RNA polymerase II transcription factor binding
is_a: GO:0001134 ! transcription factor activity, transcription factor recruiting
created_by: kchris
creation_date: 2011-01-20T05:13:12Z

[Term]
id: GO:0001136
name: transcription factor activity, TFIIE-class transcription factor recruiting
namespace: molecular_function
def: "Interacting selectively and non-covalently with a basal RNA polymerase II (RNAP II) transcription factor of the TFIIE-class in order to recruit it to the RNAP II preinitiation complex (PIC) in order to modulate transcription by RNAP II." [GOC:txnOH, PMID:16858867]
synonym: "TFIIE-class transcription factor recruiting transcription factor activity" EXACT []
is_a: GO:0001088 ! transcription factor activity, TFIIE-class binding
is_a: GO:0001135 ! transcription factor activity, RNA polymerase II transcription factor recruiting
relationship: part_of GO:0051123 ! RNA polymerase II transcriptional preinitiation complex assembly
created_by: kchris
creation_date: 2011-01-20T05:24:07Z

[Term]
id: GO:0001137
name: transcription factor activity, TFIIF-class transcription factor recruiting
namespace: molecular_function
def: "Interacting selectively and non-covalently with a basal RNA polymerase II (RNAP II) transcription factor of the TFIIF-class in order to recruit it to the RNAP II preinitiation complex (PIC) in order to modulate transcription by RNAP II." [GOC:txnOH, PMID:16858867]
synonym: "TFIIF-class transcription factor recruiting transcription factor activity" EXACT []
is_a: GO:0001089 ! transcription factor activity, TFIIF-class transcription factor binding
is_a: GO:0001135 ! transcription factor activity, RNA polymerase II transcription factor recruiting
relationship: part_of GO:0051123 ! RNA polymerase II transcriptional preinitiation complex assembly
created_by: kchris
creation_date: 2011-01-20T05:35:02Z

[Term]
id: GO:0001138
name: transcription factor activity, TFIIH-class transcription factor recruiting
namespace: molecular_function
def: "Interacting selectively and non-covalently with a basal RNA polymerase II (RNAP II) transcription factor of the TFIIH-class in order to recruit it to the RNAP II preinitiation complex (PIC) in order to modulate transcription by RNAP II." [GOC:txnOH, PMID:16858867]
synonym: "TFIIH-class transcription factor recruiting transcription factor activity" EXACT []
is_a: GO:0001090 ! transcription factor activity, TFIIH-class binding
is_a: GO:0001135 ! transcription factor activity, RNA polymerase II transcription factor recruiting
relationship: part_of GO:0051123 ! RNA polymerase II transcriptional preinitiation complex assembly
created_by: kchris
creation_date: 2011-01-20T05:39:10Z

[Term]
id: GO:0001139
name: transcription factor activity, core RNA polymerase II recruiting
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase II (Pol II) complex, typically composed of twelve subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way in order to facilitate the aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase." [GOC:txnOH, PMID:16858867]
synonym: "core RNA polymerase II recruiting transcription factor activity" EXACT []
is_a: GO:0000991 ! transcription factor activity, core RNA polymerase II binding
relationship: part_of GO:0051123 ! RNA polymerase II transcriptional preinitiation complex assembly
created_by: kchris
creation_date: 2011-01-20T05:55:01Z

[Term]
id: GO:0001140
name: transcriptional activator activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for a bacterial-type RNA polymerase in order to modulate transcription by bacterial-type RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH, PMID:20491932, PMID:20629756]
synonym: "bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription" EXACT []
is_a: GO:0001131 ! transcription factor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding
is_a: GO:0001216 ! bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
relationship: part_of GO:0001121 ! transcription from bacterial-type RNA polymerase promoter
relationship: part_of GO:0045893 ! positive regulation of transcription, DNA-templated
created_by: kchris
creation_date: 2011-01-26T03:09:27Z

[Term]
id: GO:0001141
name: transcriptional repressor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for a bacterial-type RNA polymerase in order to stop, prevent, or reduce the frequency, rate or extent of transcription from a bacterial-type RNA polymerase promoter." [GOC:txnOH, PMID:20491932, PMID:20629756]
synonym: "bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription" EXACT []
is_a: GO:0001131 ! transcription factor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding
is_a: GO:0001217 ! bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding
created_by: kchris
creation_date: 2011-01-26T03:15:45Z

[Term]
id: GO:0001142
name: mitochondrial RNA polymerase transcription factor activity, sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by mitochondrial RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH, PMID:18391175]
synonym: "sequence-specific DNA binding mitochondrial RNA polymerase transcription factor activity" EXACT []
is_a: GO:0003700 ! transcription factor activity, sequence-specific DNA binding
relationship: has_part GO:0001044 ! mitochondrial RNA polymerase regulatory region sequence-specific DNA binding
relationship: part_of GO:0006390 ! transcription from mitochondrial promoter
created_by: kchris
creation_date: 2011-01-27T01:55:21Z

[Term]
id: GO:0001143
name: mitochondrial RNA polymerase core promoter sequence-specific DNA binding transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific DNA sequence that is part of the core promoter for mitochondrial RNA polymerase in order to modulate transcription by mitochondrial RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH, PMID:18391175]
is_a: GO:0001142 ! mitochondrial RNA polymerase transcription factor activity, sequence-specific DNA binding
relationship: has_part GO:0000997 ! mitochondrial RNA polymerase core promoter sequence-specific DNA binding
created_by: kchris
creation_date: 2011-01-27T02:08:44Z

[Term]
id: GO:0001144
name: transcription factor activity, mitochondrial RNA polymerase core promoter proximal region sequence-specific binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for a mitochondrial RNA polymerase in order to modulate transcription by mitochondrial RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH, PMID:18391175]
synonym: "mitochondrial RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity" EXACT []
is_a: GO:0001142 ! mitochondrial RNA polymerase transcription factor activity, sequence-specific DNA binding
relationship: has_part GO:0001045 ! mitochondrial RNA polymerase core promoter proximal region sequence-specific DNA binding
created_by: kchris
creation_date: 2011-01-27T02:11:59Z

[Term]
id: GO:0001145
name: mitochondrial RNA polymerase termination site sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is a terminator for mitochondrial RNA polymerase." [GOC:txnOH, PMID:18391175]
is_a: GO:0001044 ! mitochondrial RNA polymerase regulatory region sequence-specific DNA binding
is_a: GO:0001147 ! transcription termination site sequence-specific DNA binding
created_by: kchris
creation_date: 2011-01-27T02:34:53Z

[Term]
id: GO:0001146
name: transcription factor activity, mitochondrial RNA polymerase terminator site sequence-specific binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is a terminator for mitochondrial RNA polymerase in order to promote transcription termination by mitochondrial RNA polymerase." [GOC:txnOH, PMID:18391175]
synonym: "mitochondrial RNA polymerase terminator site sequence-specific DNA binding transcription factor activity" EXACT []
is_a: GO:0001142 ! mitochondrial RNA polymerase transcription factor activity, sequence-specific DNA binding
relationship: has_part GO:0001145 ! mitochondrial RNA polymerase termination site sequence-specific DNA binding
relationship: part_of GO:0006393 ! termination of mitochondrial transcription
created_by: kchris
creation_date: 2011-01-27T02:42:23Z

[Term]
id: GO:0001147
name: transcription termination site sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that promotes termination by RNA polymerase. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH, PMID:18280161, PMID:18391175]
comment: Transcription termination sites can be recognized by the RNA polymerase (RNAP) itself or by another protein which interacts with the RNAP to promote transcription termination. Note that not all genes have a specific sequence that functions as a termination site; for most mRNAs transcribed by RNAP II termination is not mediated by a specific termination sequence, but is coupled to polyadenylation.
is_a: GO:0000976 ! transcription regulatory region sequence-specific DNA binding
is_a: GO:0001160 ! transcription termination site DNA binding
created_by: kchris
creation_date: 2011-01-27T02:48:26Z

[Term]
id: GO:0001148
name: bacterial-type RNA polymerase termination site sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is a terminator for bacterial-type RNA polymerase." [GOC:txnOH, PMID:18280161]
is_a: GO:0000984 ! bacterial-type RNA polymerase regulatory region sequence-specific DNA binding
is_a: GO:0001147 ! transcription termination site sequence-specific DNA binding
created_by: kchris
creation_date: 2011-01-27T03:04:07Z

[Term]
id: GO:0001149
name: transcription factor activity, bacterial-type RNA polymerase termination site sequence-specific binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is a termination site for bacterial-type RNA polymerase in order to promote transcription termination by bacterial-type RNA polymerase." [GOC:txnOH, PMID:18280161]
synonym: "bacterial-type RNA polymerase termination site sequence-specific DNA binding transcription factor activity" EXACT []
is_a: GO:0001130 ! bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding
relationship: has_part GO:0001148 ! bacterial-type RNA polymerase termination site sequence-specific DNA binding
created_by: kchris
creation_date: 2011-01-27T03:08:41Z

[Term]
id: GO:0001150
name: bacterial-type RNA polymerase enhancer sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is an enhancer region that helps activate transcription of a gene or operon by a bacterial-type RNA polymerase. Enhancers for sigma-54 holoenzymes are typically located 80 to 150 base pairs upstream from the transcription start site, although they can be further away or may be downstream of the promoter. Some transcription units dependent on sigma-70 holoenzymes may also include enhancer sequences." [GOC:txnOH, PMID:11282468, PMID:20629756]
comment: Note that the phrase "upstream activating sequence", or UAS is often used in S. cerevisiae literature to refer to regulatory sequences that occur in the region upstream and proximal to the core promoter. In contrast, in bacteria such as E. coli, the phrase "upstream activating sequence", or UAS is a synonym for "enhancer".
synonym: "bacterial-type RNA polymerase upstream activating sequence (UAS) sequence-specific DNA binding" EXACT []
is_a: GO:0000984 ! bacterial-type RNA polymerase regulatory region sequence-specific DNA binding
is_a: GO:0001158 ! enhancer sequence-specific DNA binding
created_by: kchris
creation_date: 2011-01-27T03:42:53Z

[Term]
id: GO:0001151
name: transcription factor activity, bacterial-type RNA polymerase transcription enhancer sequence-specific binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is a bacterial-type enhancer region in order to activate transcription by bacterial-type RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. Enhancers for sigma-54 holoenzymes are typically located 80 to 150 base pairs upstream from the transcription start site. Some transcription units dependent on sigma-70 holoenzymes may also include enhancer sequences." [GOC:txnOH, PMID:20629756]
synonym: "bacterial-type RNA polymerase transcription enhancer sequence-specific DNA binding transcription factor activity" EXACT []
is_a: GO:0001130 ! bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding
relationship: has_part GO:0001150 ! bacterial-type RNA polymerase enhancer sequence-specific DNA binding
created_by: kchris
creation_date: 2011-01-27T03:47:54Z

[Term]
id: GO:0001152
name: transcription factor activity, RNA polymerase III type 1 promoter sequence-specific binding, TFIIIC recruiting
namespace: molecular_function
def: "The function of binding to a specific DNA sequence motif in a type 1 RNA polymerase III (Pol III) promoter in order to recruit the transcription factor TFIIIC to the promoter." [GOC:txnOH, PMID:12381659]
comment: This represents TFIIIA.
synonym: "RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIC recruiting transcription factor activity" EXACT []
synonym: "TFIIIA activity" RELATED []
synonym: "type 1 RNA polymerase III promoter recognition" EXACT []
is_a: GO:0001010 ! transcription factor activity, sequence-specific DNA binding transcription factor recruiting
is_a: GO:0001153 ! transcription factor activity, RNA polymerase III transcription factor recruiting
relationship: has_part GO:0001002 ! RNA polymerase III type 1 promoter sequence-specific DNA binding
relationship: has_part GO:0001156 ! TFIIIC-class transcription factor binding
relationship: part_of GO:0000999 ! RNA polymerase III type 1 promoter transcriptional preinitiation complex assembly
created_by: kchris
creation_date: 2011-01-27T04:18:21Z

[Term]
id: GO:0001153
name: transcription factor activity, RNA polymerase III transcription factor recruiting
namespace: molecular_function
def: "The function of binding to an RNA polymerase III (RNAP III) transcription factor and recruiting it to the transcription machinery complex in order to modulate transcription by RNAP III." [GOC:txnOH]
synonym: "RNA polymerase III transcription factor recruiting transcription factor activity" EXACT []
is_a: GO:0001007 ! transcription factor activity, RNA polymerase III transcription factor binding
is_a: GO:0001134 ! transcription factor activity, transcription factor recruiting
created_by: kchris
creation_date: 2011-01-27T04:45:37Z

[Term]
id: GO:0001154
name: TFIIIB-class transcription factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase III transcription factor of the TFIIIB class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase III." [GOC:txnOH, PMID:12381659]
is_a: GO:0001025 ! RNA polymerase III transcription factor binding
created_by: kchris
creation_date: 2011-01-27T04:53:50Z

[Term]
id: GO:0001155
name: TFIIIA-class transcription factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase III transcription factor of the TFIIIA class, one of the factors involved in formation of the preinitiation complex (PIC) at type 1 promoters (5S genes) by RNA polymerase III." [GOC:txnOH, PMID:12381659]
is_a: GO:0001025 ! RNA polymerase III transcription factor binding
created_by: kchris
creation_date: 2011-01-27T04:57:49Z

[Term]
id: GO:0001156
name: TFIIIC-class transcription factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase III transcription factor of the TFIIIC class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase III." [GOC:txnOH, PMID:12381659]
is_a: GO:0001025 ! RNA polymerase III transcription factor binding
created_by: kchris
creation_date: 2011-01-27T05:02:22Z

[Term]
id: GO:0001157
name: transcription factor activity, RNA polymerase III type 1 promoter TFIIIB
namespace: molecular_function
def: "The function of binding to a specific DNA sequence motif in a type 1 RNA polymerase III (Pol III) promoter in order to recruit the Pol III recruiting factor TFIIIB to the promoter. For type 1 Pol III promoters, this requires both TFIIIA and TFIIIC." [GOC:txnOH, PMID:12381659]
comment: This represents TFIIIA.
synonym: "RNA polymerase III type 1 promoter TFIIIB recruiting transcription factor activity" EXACT []
synonym: "TFIIIC-type activity" RELATED []
is_a: GO:0001153 ! transcription factor activity, RNA polymerase III transcription factor recruiting
relationship: has_part GO:0001154 ! TFIIIB-class transcription factor binding
relationship: has_part GO:0001155 ! TFIIIA-class transcription factor binding
relationship: part_of GO:0000999 ! RNA polymerase III type 1 promoter transcriptional preinitiation complex assembly
created_by: kchris
creation_date: 2011-01-27T05:27:28Z

[Term]
id: GO:0001158
name: enhancer sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific sequence of DNA that is part of an enhancer, a transcription regulatory region that is somewhat distal from the core promoter and which enhances transcription from that promoter." [GOC:txnOH]
is_a: GO:0000976 ! transcription regulatory region sequence-specific DNA binding
is_a: GO:0035326 ! enhancer binding
created_by: kchris
creation_date: 2011-01-28T03:29:40Z

[Term]
id: GO:0001159
name: core promoter proximal region DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a region of DNA that is in cis with and relatively close to the core promoter. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]
is_a: GO:0044212 ! transcription regulatory region DNA binding
created_by: kchris
creation_date: 2011-01-28T03:37:52Z

[Term]
id: GO:0001160
name: transcription termination site DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a region of DNA that promotes termination by RNA polymerase. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]
is_a: GO:0044212 ! transcription regulatory region DNA binding
created_by: kchris
creation_date: 2011-01-28T03:39:44Z

[Term]
id: GO:0001161
name: intronic transcription regulatory region sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an intronic DNA sequence that regulates the transcription of the transcript it is contained within." [GOC:txnOH]
is_a: GO:0044213 ! intronic transcription regulatory region DNA binding
created_by: kchris
creation_date: 2011-01-28T03:44:02Z

[Term]
id: GO:0001162
name: RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase II intronic DNA sequence that regulates the transcription of the transcript it is contained within." [GOC:txnOH]
is_a: GO:0000977 ! RNA polymerase II regulatory region sequence-specific DNA binding
is_a: GO:0001161 ! intronic transcription regulatory region sequence-specific DNA binding
created_by: kchris
creation_date: 2011-01-28T03:46:19Z

[Term]
id: GO:0001163
name: RNA polymerase I regulatory region sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase I." [GOC:txnOH]
is_a: GO:0001013 ! RNA polymerase I regulatory region DNA binding
created_by: kchris
creation_date: 2011-01-31T04:12:06Z

[Term]
id: GO:0001164
name: RNA polymerase I CORE element sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery. This site is often referred to as the CORE element. In mammalian cells, the CORE element functions in conjunction with the Upstream Control Element (UCE), while in fungi, protozoa, and plants, the CORE element functions without a UCE." [GOC:txnOH, PMID:12865296, PMID:14969726, PMID:8057832]
synonym: "RNA polymerase I core element sequence-specific DNA binding" EXACT []
synonym: "RNA polymerase I core promoter sequence-specific DNA binding" EXACT []
is_a: GO:0001046 ! core promoter sequence-specific DNA binding
is_a: GO:0001163 ! RNA polymerase I regulatory region sequence-specific DNA binding
created_by: kchris
creation_date: 2011-01-31T04:47:48Z

[Term]
id: GO:0001165
name: RNA polymerase I upstream control element sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the upstream control element (UCE, or alternately referred to as the upstream element), a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase I." [GOC:txnOH, PMID:12865296, PMID:14969726, PMID:8057832]
synonym: "RNA polymerase I upstream element sequence-specific DNA binding" RELATED []
is_a: GO:0000987 ! core promoter proximal region sequence-specific DNA binding
is_a: GO:0001163 ! RNA polymerase I regulatory region sequence-specific DNA binding
created_by: kchris
creation_date: 2011-01-31T05:09:10Z

[Term]
id: GO:0001166
name: RNA polymerase I enhancer sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a RNA polymerase I (Pol I) enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter." [GOC:txnOH, PMID:12865296, PMID:14969726, PMID:8057832]
is_a: GO:0001158 ! enhancer sequence-specific DNA binding
is_a: GO:0001163 ! RNA polymerase I regulatory region sequence-specific DNA binding
created_by: kchris
creation_date: 2011-01-31T05:29:59Z

[Term]
id: GO:0001167
name: RNA polymerase I transcription factor activity, sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase I. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH]
synonym: "sequence-specific DNA binding RNA polymerase I transcription factor activity" EXACT []
is_a: GO:0003700 ! transcription factor activity, sequence-specific DNA binding
relationship: part_of GO:0006356 ! regulation of transcription from RNA polymerase I promoter
created_by: kchris
creation_date: 2011-02-03T04:07:46Z

[Term]
id: GO:0001168
name: transcription factor activity, RNA polymerase I upstream control element sequence-specific binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the upstream control element (UCE, or alternately referred to as the upstream element, UE), a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase I in order to modulate transcription by RNA polymerase I." [GOC:txnOH, PMID:12865296, PMID:14969726, PMID:8057832]
synonym: "RNA polymerase I upstream control element sequence-specific DNA binding transcription factor activity" EXACT []
is_a: GO:0001167 ! RNA polymerase I transcription factor activity, sequence-specific DNA binding
relationship: has_part GO:0001165 ! RNA polymerase I upstream control element sequence-specific DNA binding
created_by: kchris
creation_date: 2011-02-03T04:10:23Z

[Term]
id: GO:0001169
name: transcription factor activity, RNA polymerase I CORE element sequence-specific binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with CORE element, a regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery in order to modulate transcription by RNA polymerase I." [GOC:txnOH, PMID:12865296, PMID:14969726, PMID:8057832]
synonym: "RNA polymerase I CORE element sequence-specific DNA binding transcription factor activity" EXACT []
synonym: "RNA polymerase I core promoter sequence-specific DNA binding transcription factor" EXACT []
is_a: GO:0001167 ! RNA polymerase I transcription factor activity, sequence-specific DNA binding
relationship: has_part GO:0001164 ! RNA polymerase I CORE element sequence-specific DNA binding
created_by: kchris
creation_date: 2011-02-03T04:10:42Z

[Term]
id: GO:0001170
name: transcription factor activity, RNA polymerase I enhancer sequence-specific binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a RNA polymerase I (Pol I) enhancer in order to modulate transcription by RNA polymerase I." [GOC:txnOH, PMID:12865296, PMID:14969726, PMID:8057832]
synonym: "RNA polymerase I enhancer sequence-specific DNA binding transcription factor activity" EXACT []
is_a: GO:0001167 ! RNA polymerase I transcription factor activity, sequence-specific DNA binding
relationship: has_part GO:0001166 ! RNA polymerase I enhancer sequence-specific DNA binding
created_by: kchris
creation_date: 2011-02-03T04:10:59Z

[Term]
id: GO:0001171
name: reverse transcription
namespace: biological_process
def: "A DNA synthesis process that uses RNA as the initial template for synthesis of DNA, but which also includes an RNase activity to remove the RNA strand of an RNA-DNA heteroduplex produced by the RNA-dependent synthesis step and use of the initial DNA strand as a template for DNA synthesis." [GOC:txnOH, PMID:20358252]
xref: Wikipedia:Reverse_transcription
is_a: GO:0006278 ! RNA-dependent DNA biosynthetic process
relationship: has_part GO:0003964 ! RNA-directed DNA polymerase activity
relationship: has_part GO:0004533 ! exoribonuclease H activity
created_by: kchris
creation_date: 2011-03-14T03:51:08Z

[Term]
id: GO:0001172
name: transcription, RNA-templated
namespace: biological_process
def: "The cellular synthesis of RNA on a template of RNA." [GOC:txnOH]
subset: gosubset_prok
synonym: "transcription, RNA-dependent" EXACT [GOC:txnOH]
is_a: GO:0097659 ! nucleic acid-templated transcription
created_by: kchris
creation_date: 2011-03-14T03:54:46Z

[Term]
id: GO:0001173
name: DNA-templated transcriptional start site selection
namespace: biological_process
def: "Any process involved in the selection of the specific location within the template strand of a DNA-dependent RNA polymerase promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript." [GOC:txnOH, PMID:16826228, PMID:18846104]
synonym: "DNA-dependent transcriptional start site selection" EXACT [GOC:txnOH]
is_a: GO:0032774 ! RNA biosynthetic process
relationship: part_of GO:0006352 ! DNA-templated transcription, initiation
created_by: kchris
creation_date: 2011-06-20T12:44:11Z

[Term]
id: GO:0001174
name: transcriptional start site selection at RNA polymerase II promoter
namespace: biological_process
def: "Any process involved in the selection of the specific location within the template strand of an RNA polymerase II promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript." [GOC:txnOH, PMID:16826228, PMID:18846104]
is_a: GO:0001173 ! DNA-templated transcriptional start site selection
relationship: part_of GO:0006367 ! transcription initiation from RNA polymerase II promoter
created_by: kchris
creation_date: 2011-06-20T01:35:28Z

[Term]
id: GO:0001175
name: transcriptional start site selection at RNA polymerase III promoter
namespace: biological_process
def: "Any process involved in the selection of the specific location within the template strand of an RNA polymerase III promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript." [GOC:txnOH]
is_a: GO:0001173 ! DNA-templated transcriptional start site selection
relationship: part_of GO:0006384 ! transcription initiation from RNA polymerase III promoter
created_by: kchris
creation_date: 2011-06-20T01:47:38Z

[Term]
id: GO:0001176
name: transcriptional start site selection at bacterial-type RNA polymerase promoter
namespace: biological_process
def: "Any process involved in the selection of the specific location within the template strand of a bacterial-type RNA polymerase promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript." [GOC:txnOH]
is_a: GO:0001173 ! DNA-templated transcriptional start site selection
relationship: part_of GO:0001123 ! transcription initiation from bacterial-type RNA polymerase promoter
created_by: kchris
creation_date: 2011-06-20T01:48:56Z

[Term]
id: GO:0001177
name: regulation of transcriptional open complex formation at RNA polymerase II promoter
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of a process involved the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase II preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble." [GOC:txnOH]
is_a: GO:0060260 ! regulation of transcription initiation from RNA polymerase II promoter
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001113 ! transcriptional open complex formation at RNA polymerase II promoter
relationship: regulates GO:0001113 ! transcriptional open complex formation at RNA polymerase II promoter
created_by: kchris
creation_date: 2011-06-20T02:01:18Z

[Term]
id: GO:0001178
name: regulation of transcriptional start site selection at RNA polymerase II promoter
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of a process involved in the selection of the specific location within the template strand of an RNA polymerase II promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript." [GOC:txnOH]
is_a: GO:0060260 ! regulation of transcription initiation from RNA polymerase II promoter
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001174 ! transcriptional start site selection at RNA polymerase II promoter
relationship: regulates GO:0001174 ! transcriptional start site selection at RNA polymerase II promoter
created_by: kchris
creation_date: 2011-06-20T02:06:00Z

[Term]
id: GO:0001179
name: RNA polymerase I transcription factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase I transcription factor, any protein required to initiate or regulate transcription by RNA polymerase I." [GOC:txnOH]
is_a: GO:0008134 ! transcription factor binding
created_by: kchris
creation_date: 2011-08-12T03:03:03Z

[Term]
id: GO:0001180
name: transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript
namespace: biological_process
def: "Any process involved in the assembly of the RNA polymerase I preinitiation complex (PIC) at an polymerase I promoter for the nuclear large ribosomal RNA (rRNA) transcript, resulting in the subsequent synthesis of rRNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:txnOH]
is_a: GO:0006361 ! transcription initiation from RNA polymerase I promoter
relationship: part_of GO:0042790 ! transcription of nuclear large rRNA transcript from RNA polymerase I promoter
created_by: kchris
creation_date: 2011-08-15T03:45:49Z

[Term]
id: GO:0001181
name: transcription factor activity, core RNA polymerase I binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase I (RNAP I) complex, typically composed of fourteen subunits, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH]
synonym: "core RNA polymerase I binding transcription factor activity" EXACT []
is_a: GO:0000990 ! transcription factor activity, core RNA polymerase binding
intersection_of: GO:0003674 ! molecular_function
intersection_of: has_part GO:0001042 ! RNA polymerase I core binding
intersection_of: part_of GO:0006356 ! regulation of transcription from RNA polymerase I promoter
relationship: has_part GO:0001042 ! RNA polymerase I core binding
relationship: part_of GO:0006356 ! regulation of transcription from RNA polymerase I promoter
created_by: kchris
creation_date: 2011-08-12T04:13:30Z

[Term]
id: GO:0001182
name: promoter clearance from RNA polymerase I promoter
namespace: biological_process
def: "Any process involved in the transition from the initiation to the elongation phases of transcription by RNA polymerase I, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors." [GOC:txnOH]
is_a: GO:0001109 ! promoter clearance during DNA-templated transcription
relationship: part_of GO:0006360 ! transcription from RNA polymerase I promoter
created_by: kchris
creation_date: 2011-08-15T03:49:28Z

[Term]
id: GO:0001183
name: transcription elongation from RNA polymerase I promoter for nuclear large rRNA transcript
namespace: biological_process
def: "The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase I promoter for the nuclear large ribosomal RNA (rRNA) transcript by the addition of ribonucleotides catalyzed by RNA polymerase I." [GOC:txnOH]
is_a: GO:0006362 ! transcription elongation from RNA polymerase I promoter
relationship: part_of GO:0042790 ! transcription of nuclear large rRNA transcript from RNA polymerase I promoter
created_by: kchris
creation_date: 2011-08-15T03:57:25Z

[Term]
id: GO:0001184
name: promoter clearance from RNA polymerase I promoter for nuclear large rRNA transcript
namespace: biological_process
def: "Any process involved in the transition from the initiation to the elongation phases of transcription by RNA polymerase I at a promoter for the nuclear large ribosomal RNA (rRNA) transcript, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors." [GOC:txnOH]
is_a: GO:0001182 ! promoter clearance from RNA polymerase I promoter
relationship: part_of GO:0042790 ! transcription of nuclear large rRNA transcript from RNA polymerase I promoter
created_by: kchris
creation_date: 2011-08-15T04:03:52Z

[Term]
id: GO:0001185
name: termination of RNA polymerase I transcription from promoter for nuclear large rRNA transcript
namespace: biological_process
def: "The process in which the synthesis of an rRNA molecule from a promoter for the nuclear large ribosomal RNA (rRNA) transcript by RNA polymerase I using a DNA template is completed. RNAP I termination requires binding of a terminator protein so specific sequences downstream of the transcription unit." [GOC:txnOH]
is_a: GO:0006363 ! termination of RNA polymerase I transcription
relationship: part_of GO:0042790 ! transcription of nuclear large rRNA transcript from RNA polymerase I promoter
created_by: kchris
creation_date: 2011-08-15T04:07:43Z

[Term]
id: GO:0001186
name: transcription factor activity, RNA polymerase I transcription factor recruiting
namespace: molecular_function
def: "The function of binding to an RNA polymerase I (RNAP I) transcription factor and recruiting it to the transcription machinery complex in order to modulate transcription by RNAP I." [GOC:txnOH, PMID:12381659, PMID:14969726, PMID:8057832]
synonym: "RNA polymerase I transcription factor recruiting transcription factor activity" EXACT []
is_a: GO:0001082 ! transcription factor activity, RNA polymerase I transcription factor binding
is_a: GO:0001134 ! transcription factor activity, transcription factor recruiting
created_by: kchris
creation_date: 2011-08-24T04:00:18Z

[Term]
id: GO:0001187
name: transcription factor activity, RNA polymerase I CORE element binding transcription factor recruiting
namespace: molecular_function
def: "Interacting selectively and non-covalently with the CORE element, a regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery and also binding to an RNA polymerase I (RNAP I) transcription factor to recruit it to the transcription machinery complex in order to modulate transcription by RNA polymerase I." [GOC:txnOH, PMID:12381659, PMID:14969726, PMID:8057832]
synonym: "RNA polymerase I CORE element sequence-specific DNA binding transcription factor recruiting transcription factor activity" EXACT []
is_a: GO:0001169 ! transcription factor activity, RNA polymerase I CORE element sequence-specific binding
is_a: GO:0001186 ! transcription factor activity, RNA polymerase I transcription factor recruiting
relationship: part_of GO:0001189 ! RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript
created_by: kchris
creation_date: 2011-08-24T04:07:50Z

[Term]
id: GO:0001188
name: RNA polymerase I transcriptional preinitiation complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase I promoter." [GOC:txnOH, PMID:12381659, PMID:14969726, PMID:8057832]
is_a: GO:0070897 ! DNA-templated transcriptional preinitiation complex assembly
relationship: part_of GO:0006361 ! transcription initiation from RNA polymerase I promoter
created_by: kchris
creation_date: 2011-08-24T04:16:28Z

[Term]
id: GO:0001189
name: RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins on CORE promoter element DNA of the nuclear large ribosomal RNA (rRNA) transcript to form a transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from the large rRNA promoter, resulting in the subsequent synthesis of the large rRNA transcript." [GOC:txnOH, PMID:12381659, PMID:14969726, PMID:8057832]
is_a: GO:0001188 ! RNA polymerase I transcriptional preinitiation complex assembly
relationship: part_of GO:0001180 ! transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript
created_by: kchris
creation_date: 2011-08-24T04:20:43Z

[Term]
id: GO:0001190
name: transcriptional activator activity, RNA polymerase II transcription factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to increase the frequency, rate or extent of transcription from an RNA polymerase II promoter. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH]
synonym: "RNA polymerase II transcription factor binding transcription activator activity" EXACT []
synonym: "RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription" EXACT []
is_a: GO:0098811 ! transcriptional repressor activity, RNA polymerase II activating transcription factor binding
intersection_of: GO:0000988 ! transcription factor activity, protein binding
intersection_of: has_part GO:0001085 ! RNA polymerase II transcription factor binding
intersection_of: regulates GO:0006366 ! transcription from RNA polymerase II promoter
relationship: has_part GO:0001085 ! RNA polymerase II transcription factor binding
relationship: part_of GO:0006366 ! transcription from RNA polymerase II promoter
relationship: part_of GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
relationship: regulates GO:0006366 ! transcription from RNA polymerase II promoter
created_by: kchris
creation_date: 2011-08-25T02:07:14Z

[Term]
id: GO:0001191
name: transcriptional repressor activity, RNA polymerase II transcription factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH, PMID:9811836]
synonym: "RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription" EXACT []
synonym: "RNA polymerase II transcription factor binding transcription repressor activity" EXACT []
synonym: "RNA polymerase II transcription repressor activity" BROAD []
is_a: GO:0001076 ! transcription factor activity, RNA polymerase II transcription factor binding
intersection_of: GO:0000988 ! transcription factor activity, protein binding
intersection_of: has_part GO:0001085 ! RNA polymerase II transcription factor binding
intersection_of: part_of GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
relationship: has_part GO:0001085 ! RNA polymerase II transcription factor binding
relationship: part_of GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
created_by: kchris
creation_date: 2011-08-25T02:12:30Z

[Term]
id: GO:0001192
name: maintenance of transcriptional fidelity during DNA-templated transcription elongation
namespace: biological_process
def: "Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation on a DNA template." [GOC:txnOH]
synonym: "maintenance of transcriptional fidelity during DNA-dependent transcription elongation" EXACT [GOC:txnOH]
is_a: GO:0032774 ! RNA biosynthetic process
relationship: part_of GO:0006354 ! DNA-templated transcription, elongation
created_by: kchris
creation_date: 2011-09-02T02:25:30Z

[Term]
id: GO:0001193
name: maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter
namespace: biological_process
def: "Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation from an RNA polymerase II promoter." [GOC:txnOH, PMID:14531857, PMID:16492753, PMID:17535246]
synonym: "maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase II promoter" EXACT [GOC:txnOH]
is_a: GO:0001192 ! maintenance of transcriptional fidelity during DNA-templated transcription elongation
relationship: part_of GO:0006368 ! transcription elongation from RNA polymerase II promoter
created_by: kchris
creation_date: 2011-09-02T02:31:00Z

[Term]
id: GO:0001194
name: maintenance of transcriptional fidelity during DNA-templated transcription elongation from bacterial-type RNA polymerase promoter
namespace: biological_process
def: "Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation from a bacterial-type RNA polymerase promoter." [GOC:txnOH]
synonym: "maintenance of transcriptional fidelity during DNA-dependent transcription elongation from bacterial-type RNA polymerase promoter" EXACT [GOC:txnOH]
is_a: GO:0001192 ! maintenance of transcriptional fidelity during DNA-templated transcription elongation
relationship: part_of GO:0001124 ! transcription elongation from bacterial-type RNA polymerase promoter
created_by: kchris
creation_date: 2011-09-02T02:37:59Z

[Term]
id: GO:0001195
name: maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase III promoter
namespace: biological_process
def: "Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation from a RNA polymerase III promoter." [GOC:txnOH]
synonym: "maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase III promoter" EXACT [GOC:txnOH]
is_a: GO:0001192 ! maintenance of transcriptional fidelity during DNA-templated transcription elongation
relationship: part_of GO:0006385 ! transcription elongation from RNA polymerase III promoter
created_by: kchris
creation_date: 2011-09-02T02:41:29Z

[Term]
id: GO:0001196
name: regulation of mating-type specific transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any mating-type specific process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:txnOH]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0007532 ! regulation of mating-type specific transcription, DNA-templated
intersection_of: GO:0007532 ! regulation of mating-type specific transcription, DNA-templated
intersection_of: regulates GO:0006366 ! transcription from RNA polymerase II promoter
relationship: regulates GO:0006366 ! transcription from RNA polymerase II promoter
created_by: kchris
creation_date: 2011-11-23T09:25:32Z

[Term]
id: GO:0001197
name: positive regulation of mating-type specific transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any mating-type specific process that activates or increases the rate of transcription from an RNA polymerase II promoter." [GOC:txnOH]
synonym: "activation of transcription from an RNA polymerase II promoter, mating-type specific" NARROW []
synonym: "stimulation of transcription from an RNA polymerase II promoter, mating-type specific" NARROW []
synonym: "up regulation of transcription from an RNA polymerase II promoter, mating-type specific" EXACT []
synonym: "up-regulation of transcription from an RNA polymerase II promoter, mating-type specific" EXACT []
synonym: "upregulation of transcription from an RNA polymerase II promoter, mating-type specific" EXACT []
is_a: GO:0001196 ! regulation of mating-type specific transcription from RNA polymerase II promoter
is_a: GO:0045895 ! positive regulation of mating-type specific transcription, DNA-templated
intersection_of: GO:0045895 ! positive regulation of mating-type specific transcription, DNA-templated
intersection_of: regulates GO:0006366 ! transcription from RNA polymerase II promoter
relationship: regulates GO:0006366 ! transcription from RNA polymerase II promoter
created_by: kchris
creation_date: 2011-11-23T09:31:33Z

[Term]
id: GO:0001198
name: negative regulation of mating-type specific transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any mating-type specific process that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter." [GOC:txnOH]
synonym: "down regulation of RNA polymerase II transcription, mating-type specific" EXACT []
synonym: "down-regulation of RNA polymerase II transcription, mating-type specific" EXACT []
synonym: "downregulation of RNA polymerase II transcription, mating-type specific" EXACT []
synonym: "inhibition of RNA polymerase II transcription, mating-type specific" NARROW []
is_a: GO:0001196 ! regulation of mating-type specific transcription from RNA polymerase II promoter
is_a: GO:0045894 ! negative regulation of mating-type specific transcription, DNA-templated
intersection_of: GO:0045894 ! negative regulation of mating-type specific transcription, DNA-templated
intersection_of: regulates GO:0006366 ! transcription from RNA polymerase II promoter
relationship: regulates GO:0006366 ! transcription from RNA polymerase II promoter
created_by: kchris
creation_date: 2011-11-23T09:36:06Z

[Term]
id: GO:0001199
name: transcription factor activity, metal ion regulated sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific DNA sequence and interacting selectively and non-covalently with any metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of those metal ions, in such a way that metal ion binding regulates the activity of the transcription factor in order to modulate transcription by an RNA polymerase. Specific mechanisms include increasing or decreasing the ability of the transcription factor to interact selectively and non-covalently with a specific DNA sequence (for example S. cerevisiae Cup2p or the prokaryotic SmtB/ArsR family, changing the conformation of transcription factor bound DNA between the apo- and metal-bound forms of the transcription factor. Additional mechanisms may exist." [GOC:txnOH, PMID:12829264, PMID:12829265, PMID:22084422, PMID:2674688]
comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor.
synonym: "metal ion regulated sequence-specific DNA binding transcription factor activity" EXACT []
is_a: GO:0003700 ! transcription factor activity, sequence-specific DNA binding
relationship: has_part GO:0046872 ! metal ion binding
relationship: part_of GO:0071248 ! cellular response to metal ion
created_by: kchris
creation_date: 2011-11-23T10:52:49Z

[Term]
id: GO:0001200
name: RNA polymerase II transcription factor activity, metal ion regulated sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific DNA sequence and interacting selectively and non-covalently with any metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of those metal ions, in such a way that metal ion binding regulates the activity of the transcription factor in order to modulate transcription by RNA polymerase II. Specific mechanisms include increasing or decreasing the ability of the transcription factor to interact selectively and non-covalently with a specific DNA sequence (for example S. cerevisiae Cup2p or the prokaryotic SmtB/ArsR family, changing the conformation of transcription factor bound DNA between the apo- and metal-bound forms of the transcription factor. Additional mechanisms may exist." [GOC:txnOH, PMID:12829264, PMID:12829265, PMID:2674688]
comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor.
synonym: "metal ion regulated sequence-specific DNA binding RNA polymerase II transcription factor activity" EXACT []
is_a: GO:0000981 ! RNA polymerase II transcription factor activity, sequence-specific DNA binding
is_a: GO:0001199 ! transcription factor activity, metal ion regulated sequence-specific DNA binding
created_by: kchris
creation_date: 2011-11-23T11:18:49Z

[Term]
id: GO:0001201
name: RNA polymerase II transcription factor activity, metal ion regulated core promoter proximal region sequence-specific binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific DNA sequence that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) and interacting selectively and non-covalently with any metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of those metal ions, in such a way that metal ion binding regulates the activity of the transcription factor that binds the core promoter proximal region in order to modulate transcription by RNA polymerase II. Specific mechanisms include increasing or decreasing the ability of the transcription factor to interact selectively and non-covalently with a specific DNA sequence (for example S. cerevisiae Cup2p or the prokaryotic SmtB/ArsR family, changing the conformation of transcription factor bound DNA between the apo- and metal-bound forms of the transcription factor. Additional mechanisms may exist." [GOC:txnOH, PMID:12829264, PMID:12829265, PMID:22084422, PMID:2674688]
comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor.
synonym: "metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity" EXACT []
is_a: GO:0000982 ! transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
is_a: GO:0001200 ! RNA polymerase II transcription factor activity, metal ion regulated sequence-specific DNA binding
created_by: kchris
creation_date: 2011-11-23T11:22:42Z

[Term]
id: GO:0001202
name: RNA polymerase II transcription factor activity, copper ion regulated core promoter proximal region sequence-specific binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific DNA sequence that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) and interacting selectively and non-covalently with copper(I) (Cu+) ion(s) and responding, e.g. by conformational change, to changes in the cellular level of copper(I) (Cu+), such a way that copper ion binding regulates the activity of the transcription factor, perhaps by regulating the ability to interact selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II), or by regulating some other function of the transcription factor, in order to modulate transcription by RNAP II." [GOC:txnOH, PMID:22084422, PMID:2674688]
comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor.
synonym: "copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity" EXACT []
is_a: GO:0001201 ! RNA polymerase II transcription factor activity, metal ion regulated core promoter proximal region sequence-specific binding
relationship: has_part GO:0005507 ! copper ion binding
relationship: part_of GO:0071280 ! cellular response to copper ion
created_by: kchris
creation_date: 2011-11-23T11:27:57Z

[Term]
id: GO:0001203
name: RNA polymerase II transcription factor activity, zinc ion regulated core promoter proximal region sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific DNA sequence that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) and interacting selectively and non-covalently with zinc (Zn) ion(s) and responding, e.g. by conformational change, to changes in the cellular level of zinc (Zn), in such a way that zinc ion binding regulates the activity of the transcription factor, perhaps by regulating the ability to interact selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II), or by regulating some other function of the transcription factor, in order to modulate transcription by RNAP II." [GOC:txnOH, PMID:22084422]
comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor.
synonym: "zinc ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity" EXACT []
is_a: GO:0001201 ! RNA polymerase II transcription factor activity, metal ion regulated core promoter proximal region sequence-specific binding
relationship: has_part GO:0008270 ! zinc ion binding
relationship: part_of GO:0071294 ! cellular response to zinc ion
created_by: kchris
creation_date: 2011-11-23T11:36:25Z

[Term]
id: GO:0001204
name: bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific bacterial-type transcription regulatory DNA sequence and interacting selectively and non-covalently with any metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of those metal ions, in such a way that metal ion binding regulates the activity of the transcription factor in order to modulate transcription by a bacterial-type RNA polymerase. Specific mechanisms include increasing or decreasing the ability of the transcription factor to interact selectively and non-covalently with a specific DNA sequence (for example S. cerevisiae Cup2p or the prokaryotic SmtB/ArsR family, changing the conformation of transcription factor bound DNA between the apo- and metal-bound forms of the transcription factor. Additional mechanisms may exist." [GOC:txnOH, PMID:12829264, PMID:12829265, PMID:22084422, PMID:2674688]
comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor.
synonym: "metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity" EXACT []
is_a: GO:0001130 ! bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding
is_a: GO:0001199 ! transcription factor activity, metal ion regulated sequence-specific DNA binding
created_by: kchris
creation_date: 2011-11-23T12:07:06Z

[Term]
id: GO:0001205
name: transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter." [GOC:txnOH]
synonym: "RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription" EXACT []
synonym: "sequence-specific distal enhancer binding RNA polymerase II transcription factor activity involved in positive regulation of transcription" EXACT []
is_a: GO:0001228 ! transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
is_a: GO:0003705 ! transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
created_by: kchris
creation_date: 2012-01-26T03:10:20Z

[Term]
id: GO:0001206
name: transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:txnOH]
synonym: "RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription" EXACT []
synonym: "sequence-specific distal enhancer binding RNA polymerase II transcription factor activity involved in negative regulation of transcription" EXACT []
is_a: GO:0001227 ! transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
is_a: GO:0003705 ! transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
created_by: kchris
creation_date: 2012-01-26T03:10:40Z

[Term]
id: GO:0001207
name: histone displacement
namespace: biological_process
def: "The removal of histones, including histone dimers, from nucleosomes within chromatin." [GOC:krc, PMID:15525516, PMID:17496903, PMID:21807128]
is_a: GO:0034728 ! nucleosome organization
created_by: karen
creation_date: 2012-03-27T10:56:56Z

[Term]
id: GO:0001208
name: histone H2A-H2B dimer displacement
namespace: biological_process
def: "The removal of a H2A-H2B histone dimer from a nucleosome within chromatin." [GOC:krc, PMID:15525516, PMID:17496903, PMID:21807128]
is_a: GO:0001207 ! histone displacement
created_by: karen
creation_date: 2012-03-27T11:03:40Z

[Term]
id: GO:0001209
name: transcriptional activator activity, metal ion regulated sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific DNA sequence and interacting selectively and non-covalently with any metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of those metal ions, in such a way that metal ion binding regulates the activity of the transcription factor in order to activate or increase the frequency, rate or extent of cellular DNA-dependent transcription by an RNA polymerase. Specific mechanisms include increasing or decreasing the ability of the transcription factor to interact selectively and non-covalently with a specific DNA sequence (for example S. cerevisiae Cup2p or the prokaryotic SmtB/ArsR family, changing the conformation of transcription factor bound DNA between the apo- and metal-bound forms of the transcription factor. Additional mechanisms may exist." [GOC:txnOH, PMID:12829264, PMID:12829265, PMID:22084422, PMID:2674688]
comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor.
synonym: "metal ion regulated sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription" EXACT []
is_a: GO:0001199 ! transcription factor activity, metal ion regulated sequence-specific DNA binding
relationship: part_of GO:0045893 ! positive regulation of transcription, DNA-templated
created_by: kchris
creation_date: 2012-04-04T02:26:42Z

[Term]
id: GO:0001210
name: transcriptional repressor activity, metal ion regulated sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific DNA sequence and interacting selectively and non-covalently with any metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of those metal ions, in such a way that metal ion binding regulates the activity of the transcription factor in order to stop, prevent, or reduce the frequency, rate or extent of cellular DNA-dependent transcription by an RNA polymerase. Specific mechanisms include increasing or decreasing the ability of the transcription factor to interact selectively and non-covalently with a specific DNA sequence (for example S. cerevisiae Cup2p or the prokaryotic SmtB/ArsR family, changing the conformation of transcription factor bound DNA between the apo- and metal-bound forms of the transcription factor. Additional mechanisms may exist." [GOC:txnOH, PMID:12829264, PMID:12829265, PMID:22084422, PMID:2674688]
comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor.
synonym: "metal ion regulated sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription" EXACT []
is_a: GO:0001199 ! transcription factor activity, metal ion regulated sequence-specific DNA binding
relationship: part_of GO:0045892 ! negative regulation of transcription, DNA-templated
created_by: kchris
creation_date: 2012-04-04T02:53:25Z

[Term]
id: GO:0001211
name: RNA polymerase II transcriptional activator activity, copper ion regulated core promoter proximal region sequence-specific binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) and interacting selectively and non-covalently with copper(I) (Cu+) ion(s) and responding, e.g. by conformational change, to changes in the cellular level of copper(I) (Cu+), such a way that copper ion binding regulates the activity of the transcription factor in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter." [GOC:txnOH, PMID:2674688]
comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor.
synonym: "copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription" EXACT []
is_a: GO:0001202 ! RNA polymerase II transcription factor activity, copper ion regulated core promoter proximal region sequence-specific binding
is_a: GO:0001213 ! RNA polymerase II transcriptional activator activity, metal ion regulated core promoter proximal region sequence-specific binding
created_by: kchris
creation_date: 2012-04-04T03:03:00Z

[Term]
id: GO:0001212
name: RNA polymerase II transcriptional activator activity, zinc ion regulated core promoter proximal region sequence-specific binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) and interacting selectively and non-covalently with zinc (Zn) ion(s) and responding, e.g. by conformational change, to changes in the cellular level of zinc (Zn), such a way that copper ion binding regulates the activity of the transcription factor in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter." [GOC:txnOH]
comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor.
synonym: "zinc ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription" EXACT []
is_a: GO:0001203 ! RNA polymerase II transcription factor activity, zinc ion regulated core promoter proximal region sequence-specific DNA binding
is_a: GO:0001213 ! RNA polymerase II transcriptional activator activity, metal ion regulated core promoter proximal region sequence-specific binding
created_by: kchris
creation_date: 2012-04-04T03:13:34Z

[Term]
id: GO:0001213
name: RNA polymerase II transcriptional activator activity, metal ion regulated core promoter proximal region sequence-specific binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) and interacting selectively and non-covalently with metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of metal ion, such a way that metal ion binding regulates the activity of the transcription factor in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter." [GOC:txnOH, PMID:22084422, PMID:2674688]
comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor.
synonym: "metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription" EXACT []
is_a: GO:0001077 ! transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
is_a: GO:0001201 ! RNA polymerase II transcription factor activity, metal ion regulated core promoter proximal region sequence-specific binding
created_by: kchris
creation_date: 2012-04-04T03:18:43Z

[Term]
id: GO:0001214
name: RNA polymerase II transcriptional repressor activity, metal ion regulated core promoter proximal region sequence-specific binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) and interacting selectively and non-covalently with metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of metal ion, such a way that metal ion binding regulates the activity of the transcription factor in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:txnOH, PMID:22084422, PMID:2674688]
comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor.
synonym: "metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in negative regulation of transcription" EXACT []
is_a: GO:0001078 ! transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
is_a: GO:0001201 ! RNA polymerase II transcription factor activity, metal ion regulated core promoter proximal region sequence-specific binding
created_by: kchris
creation_date: 2012-04-04T03:33:08Z

[Term]
id: GO:0001215
name: bacterial-type RNA polymerase transcriptional activator activity, metal ion regulated sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific bacterial-type transcription regulatory DNA sequence and interacting selectively and non-covalently with any metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of those metal ions, in such a way that metal ion binding regulates the activity of the transcription factor in order to activate or increase the frequency, rate or extent of cellular DNA-dependent transcription by a bacterial-type RNA polymerase. Specific mechanisms include increasing or decreasing the ability of the transcription factor to interact selectively and non-covalently with a specific DNA sequence (for example S. cerevisiae Cup2p or the prokaryotic SmtB/ArsR family, changing the conformation of transcription factor bound DNA between the apo- and metal-bound forms of the transcription factor. Additional mechanisms may exist." [GOC:txnOH, PMID:12829264, PMID:12829265, PMID:2674688]
comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor.
synonym: "metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in positive regulation of transcription" EXACT []
is_a: GO:0001204 ! bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
is_a: GO:0001209 ! transcriptional activator activity, metal ion regulated sequence-specific DNA binding
created_by: kchris
creation_date: 2012-04-04T03:47:42Z

[Term]
id: GO:0001216
name: bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by bacterial-type RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:krc]
synonym: "sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in positive regulation of transcription" EXACT []
is_a: GO:0001130 ! bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding
relationship: part_of GO:0045893 ! positive regulation of transcription, DNA-templated
created_by: kchris
creation_date: 2012-04-04T03:55:59Z

[Term]
id: GO:0001217
name: bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by bacterial-type RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:krc]
synonym: "sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription" EXACT []
is_a: GO:0001130 ! bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding
relationship: part_of GO:0045892 ! negative regulation of transcription, DNA-templated
created_by: kchris
creation_date: 2012-04-04T03:57:16Z

[Term]
id: GO:0001218
name: bacterial-type RNA polymerase transcriptional repressor activity, metal ion regulated sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific bacterial-type transcription regulatory DNA sequence and interacting selectively and non-covalently with any metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of those metal ions, in such a way that metal ion binding regulates the activity of the transcription factor in order to stop, prevent, or reduce the frequency, rate or extent of cellular DNA-dependent transcription by a bacterial-type RNA polymerase. Specific mechanisms include increasing or decreasing the ability of the transcription factor to interact selectively and non-covalently with a specific DNA sequence (for example S. cerevisiae Cup2p or the prokaryotic SmtB/ArsR family, changing the conformation of transcription factor bound DNA between the apo- and metal-bound forms of the transcription factor. Additional mechanisms may exist." [GOC:txnOH, PMID:12829264, PMID:12829265, PMID:2674688]
comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor.
synonym: "metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription" EXACT []
is_a: GO:0001204 ! bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
is_a: GO:0001210 ! transcriptional repressor activity, metal ion regulated sequence-specific DNA binding
created_by: kchris
creation_date: 2012-04-05T10:46:50Z

[Term]
id: GO:0001219
name: bacterial-type RNA polymerase transcriptional repressor activity, copper ion regulated sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific bacterial-type transcription regulatory DNA sequence and interacting selectively and non-covalently with copper(I) (Cu+) ion(s) and responding, e.g. by conformational change, to changes in the cellular level of copper(I) (Cu+), in such a way that copper ion binding regulates the activity of the transcription factor in order to stop, prevent, or reduce the frequency, rate or extent of cellular DNA-dependent transcription by a bacterial-type RNA polymerase." [GOC:krc, PMID:12829264, PMID:12829265, PMID:19928961]
synonym: "copper ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription" EXACT []
synonym: "copper ion sensor" RELATED []
is_a: GO:0001218 ! bacterial-type RNA polymerase transcriptional repressor activity, metal ion regulated sequence-specific DNA binding
relationship: has_part GO:0005507 ! copper ion binding
relationship: part_of GO:0071280 ! cellular response to copper ion
created_by: kchris
creation_date: 2012-04-05T11:13:34Z

[Term]
id: GO:0001220
name: bacterial-type RNA polymerase transcriptional repressor activity, cadmium ion regulated sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific bacterial-type transcription regulatory DNA sequence and interacting selectively and non-covalently with cadmium (Cd) ion(s) and responding, e.g. by conformational change, to changes in the cellular level of cadmium (Cd), in such a way that cadmium (Cd) ion binding regulates the activity of the transcription factor in order to stop, prevent, or reduce the frequency, rate or extent of cellular DNA-dependent transcription by a bacterial-type RNA polymerase." [GOC:krc, PMID:12829264, PMID:12829265, PMID:19456862]
synonym: "cadmium ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription" EXACT []
synonym: "cadmium ion sensor" RELATED []
is_a: GO:0001218 ! bacterial-type RNA polymerase transcriptional repressor activity, metal ion regulated sequence-specific DNA binding
relationship: has_part GO:0046870 ! cadmium ion binding
relationship: part_of GO:0071276 ! cellular response to cadmium ion
created_by: kchris
creation_date: 2012-04-05T11:46:06Z

[Term]
id: GO:0001221
name: transcription cofactor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a transcription cofactor, any protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery." [GOC:krc]
is_a: GO:0008134 ! transcription factor binding
created_by: kchris
creation_date: 2012-04-16T03:19:05Z

[Term]
id: GO:0001222
name: transcription corepressor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a transcription corepressor, any protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery." [GOC:krc]
is_a: GO:0001221 ! transcription cofactor binding
created_by: kchris
creation_date: 2012-04-16T03:27:26Z

[Term]
id: GO:0001223
name: transcription coactivator binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a transcription coactivator, any protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:krc]
is_a: GO:0001221 ! transcription cofactor binding
created_by: kchris
creation_date: 2012-04-16T03:30:16Z

[Term]
id: GO:0001224
name: RNA polymerase II transcription cofactor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a transcription cofactor for RNA polymerase II, any protein involved in regulation of transcription via protein-protein interactions with RNA polymerase II transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery of RNA polymerase II." [GOC:krc]
is_a: GO:0001221 ! transcription cofactor binding
created_by: kchris
creation_date: 2012-04-16T03:37:06Z

[Term]
id: GO:0001225
name: RNA polymerase II transcription coactivator binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase II transcription coactivator, any protein involved in positive regulation of transcription of RNA polymerase II via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery of RNA polymerase II." [GOC:krc]
is_a: GO:0001223 ! transcription coactivator binding
is_a: GO:0001224 ! RNA polymerase II transcription cofactor binding
created_by: kchris
creation_date: 2012-04-16T03:39:41Z

[Term]
id: GO:0001226
name: RNA polymerase II transcription corepressor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase II transcription corepressor, any protein involved in negative regulation of transcription by RNA polymerase II via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery of RNA polymerase II." [GOC:krc]
is_a: GO:0001222 ! transcription corepressor binding
is_a: GO:0001224 ! RNA polymerase II transcription cofactor binding
created_by: kchris
creation_date: 2012-04-16T03:39:47Z

[Term]
id: GO:0001227
name: transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is in the regulatory region for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:krc]
synonym: "RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription" EXACT []
is_a: GO:0000981 ! RNA polymerase II transcription factor activity, sequence-specific DNA binding
relationship: part_of GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
created_by: kchris
creation_date: 2012-04-16T04:41:29Z

[Term]
id: GO:0001228
name: transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is in the transcription regulatory region for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter." [GOC:krc]
synonym: "RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription" EXACT []
is_a: GO:0000981 ! RNA polymerase II transcription factor activity, sequence-specific DNA binding
relationship: part_of GO:0006366 ! transcription from RNA polymerase II promoter
relationship: part_of GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
created_by: kchris
creation_date: 2012-04-16T04:44:21Z

[Term]
id: GO:0001300
name: chronological cell aging
namespace: biological_process
def: "The process associated with progression of the cell from its inception to the end of its lifespan that occurs when the cell is in a non-dividing, or quiescent, state." [GOC:jh, PMID:12044934]
synonym: "chronological cell ageing" EXACT []
is_a: GO:0007569 ! cell aging

[Term]
id: GO:0001301
name: progressive alteration of chromatin involved in cell aging
namespace: biological_process
def: "The chromatin modification process that occurs during the lifespan of the cell that results in changes in chromatin structure. Such changes may lead to gene dysregulation and ultimately to a loss in cell homeostasis, bringing about an aging phenotype." [GOC:jh, PMID:12044938]
synonym: "age-dependent accumulation of genetic damage" RELATED []
synonym: "progressive alteration of chromatin during cell ageing" EXACT []
synonym: "progressive alteration of chromatin during cell aging" RELATED [GOC:dph, GOC:tb]
is_a: GO:0016568 ! chromatin modification
intersection_of: GO:0016568 ! chromatin modification
intersection_of: part_of GO:0007569 ! cell aging
relationship: part_of GO:0007569 ! cell aging

[Term]
id: GO:0001302
name: replicative cell aging
namespace: biological_process
def: "The process associated with progression of the cell from its inception to the end of its lifespan that occurs as the cell continues cycles of growth and division." [GOC:jh, PMID:12044934]
synonym: "replicative cell ageing" EXACT []
is_a: GO:0007569 ! cell aging

[Term]
id: GO:0001303
name: nucleolar fragmentation involved in replicative aging
namespace: biological_process
def: "A nucleolar fragmentation process that gives rise to multiple rounded structures and that occurs in conjunction with increasing age in dividing cells." [GOC:jh, PMID:9891807]
synonym: "nucleolar fragmentation during replicative ageing" RELATED []
synonym: "nucleolar fragmentation during replicative aging" RELATED [GOC:dph, GOC:tb]
is_a: GO:0007576 ! nucleolar fragmentation
intersection_of: GO:0007576 ! nucleolar fragmentation
intersection_of: part_of GO:0001302 ! replicative cell aging
relationship: part_of GO:0001302 ! replicative cell aging

[Term]
id: GO:0001304
name: progressive alteration of chromatin involved in replicative cell aging
namespace: biological_process
def: "A process that results in changes in chromatin structure contributing to replicative cell aging." [GOC:dph, GOC:jh, GOC:tb]
synonym: "progressive alteration of chromatin during replicative cell ageing" EXACT []
synonym: "progressive alteration of chromatin during replicative cell aging" RELATED [GOC:dph, GOC:tb]
is_a: GO:0001301 ! progressive alteration of chromatin involved in cell aging
intersection_of: GO:0001301 ! progressive alteration of chromatin involved in cell aging
intersection_of: part_of GO:0001302 ! replicative cell aging
relationship: part_of GO:0001302 ! replicative cell aging

[Term]
id: GO:0001305
name: progressive alteration of chromatin involved in chronological cell aging
namespace: biological_process
def: "A process that results in changes in chromatin structure contributing to chronological cell aging, occurring in non-dividing cells." [GOC:dph, GOC:jh, GOC:tb]
synonym: "progressive alteration of chromatin during chronological cell ageing" RELATED []
synonym: "progressive alteration of chromatin during chronological cell aging" RELATED [GOC:dph, GOC:tb]
is_a: GO:0001301 ! progressive alteration of chromatin involved in cell aging
intersection_of: GO:0001301 ! progressive alteration of chromatin involved in cell aging
intersection_of: part_of GO:0001300 ! chronological cell aging
relationship: part_of GO:0001300 ! chronological cell aging

[Term]
id: GO:0001306
name: age-dependent response to oxidative stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, where the change varies according to the age of the cell or organism." [GOC:jh, PMID:12044938]
is_a: GO:0006979 ! response to oxidative stress
relationship: part_of GO:0007571 ! age-dependent general metabolic decline

[Term]
id: GO:0001307
name: extrachromosomal circular DNA accumulation involved in replicative cell aging
namespace: biological_process
def: "Increase in abundance of circular DNA molecules in dividing cells as they age. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and then replicated independently of chromosomal replication." [GOC:jh]
synonym: "extrachromosomal circular DNA accumulation during replicative cell ageing" RELATED []
synonym: "extrachromosomal circular DNA accumulation during replicative cell aging" RELATED [GOC:dph, GOC:tb]
is_a: GO:0001304 ! progressive alteration of chromatin involved in replicative cell aging
is_a: GO:0007580 ! extrachromosomal circular DNA accumulation involved in cell aging

[Term]
id: GO:0001308
name: negative regulation of chromatin silencing involved in replicative cell aging
namespace: biological_process
def: "The process, which occurs as a dividing cell ages, leading to expression of genes that are typically not expressed due to silencing by regulatory proteins." [GOC:jh, PMID:12044934]
synonym: "loss of chromatin silencing during replicative cell ageing" RELATED []
synonym: "loss of chromatin silencing involved in replicative cell aging" EXACT []
is_a: GO:0001304 ! progressive alteration of chromatin involved in replicative cell aging
is_a: GO:0031936 ! negative regulation of chromatin silencing
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006342 ! chromatin silencing
intersection_of: part_of GO:0001302 ! replicative cell aging
relationship: negatively_regulates GO:0006342 ! chromatin silencing
relationship: part_of GO:0001302 ! replicative cell aging

[Term]
id: GO:0001309
name: obsolete age-dependent telomere shortening
namespace: biological_process
def: "OBSOLETE. Progressive reduction in length of the telomeres, the termini of eukaryotic chromosomes, that occurs as part of the cellular aging process." [GOC:jh, PMID:9891807]
comment: This term was made obsolete because it represents a phenotype.
synonym: "age-dependent telomere shortening" EXACT []
is_obsolete: true
consider: GO:1903824

[Term]
id: GO:0001310
name: extrachromosomal rDNA circle accumulation involved in replicative cell aging
namespace: biological_process
def: "Increase in abundance of circular DNA molecules containing ribosomal DNA repeats in dividing cells as they age. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and then replicated independently of chromosomal replication." [GOC:jh, PMID:12044934]
synonym: "extrachromosomal rDNA circle accumulation during replicative cell ageing" RELATED []
synonym: "extrachromosomal rDNA circle accumulation during replicative cell aging" RELATED [GOC:dph, GOC:tb]
synonym: "extrachromosomal ribosomal DNA circle accumulation during replicative cell aging" RELATED []
is_a: GO:0001307 ! extrachromosomal circular DNA accumulation involved in replicative cell aging

[Term]
id: GO:0001311
name: formation of extrachromosomal circular rDNA by homologous recombination involved in replicative cell aging
namespace: biological_process
def: "Excision from the chromosome and circularization of DNA molecules encoding ribosomal RNA in dividing cells as they age." [GOC:jh, PMID:12044934]
synonym: "assembly of extrachromosomal circular rDNA by homologous recombination involved in replicative cell aging" RELATED []
synonym: "formation of extrachromosomal circular rDNA by homologous recombination during replicative cell ageing" RELATED []
synonym: "formation of extrachromosomal circular rDNA by homologous recombination during replicative cell aging" RELATED [GOC:dph, GOC:tb]
synonym: "formation of extrachromosomal circular ribosomal DNA by homologous recombination during replicative cell aging" RELATED []
is_a: GO:0001313 ! formation of extrachromosomal circular DNA involved in replicative cell aging
is_a: GO:0045458 ! recombination within rDNA repeats
relationship: part_of GO:0001310 ! extrachromosomal rDNA circle accumulation involved in replicative cell aging

[Term]
id: GO:0001312
name: replication of extrachromosomal rDNA circles involved in replicative cell aging
namespace: biological_process
def: "Replication of rDNA following its excision from the chromosome of dividing cells as they age. Extrachromosomal rDNA forms a circle that contains at least one autonomously replicating sequence (ARS), which supports replication independent of chromosomal replication." [GOC:jh, PMID:12044934]
synonym: "replication of extrachromosomal rDNA circles during replicative cell ageing" RELATED []
synonym: "replication of extrachromosomal rDNA circles during replicative cell aging" RELATED [GOC:dph, GOC:tb]
synonym: "replication of extrachromosomal ribosomal DNA circles during replicative cell aging" RELATED []
is_a: GO:0001314 ! replication of extrachromosomal circular DNA involved in replicative cell aging
relationship: part_of GO:0001310 ! extrachromosomal rDNA circle accumulation involved in replicative cell aging

[Term]
id: GO:0001313
name: formation of extrachromosomal circular DNA involved in replicative cell aging
namespace: biological_process
def: "Excision from the chromosome and circularization of a region of chromosomal DNA, generally, but not always, via homologous recombination between direct tandem repeats, in dividing cells as they age." [GOC:jh]
synonym: "assembly of extrachromosomal circular DNA involved in replicative cell aging" EXACT []
synonym: "formation of extrachromosomal circular DNA during replicative cell ageing" RELATED []
synonym: "formation of extrachromosomal circular DNA during replicative cell aging" RELATED [GOC:dph, GOC:tb]
is_a: GO:0001325 ! formation of extrachromosomal circular DNA
intersection_of: GO:0001325 ! formation of extrachromosomal circular DNA
intersection_of: part_of GO:0001302 ! replicative cell aging
relationship: part_of GO:0001302 ! replicative cell aging
relationship: part_of GO:0001307 ! extrachromosomal circular DNA accumulation involved in replicative cell aging

[Term]
id: GO:0001314
name: replication of extrachromosomal circular DNA involved in replicative cell aging
namespace: biological_process
def: "Replication of circular DNA following excision from the chromosome of dividing cells as they age; replication of extrachromosomal circular DNA generally occurs independently of chromosomal replication." [GOC:jh]
synonym: "replication of extrachromosomal circular DNA during replicative cell ageing" EXACT []
synonym: "replication of extrachromosomal circular DNA during replicative cell aging" RELATED [GOC:dph, GOC:tb]
is_a: GO:0001326 ! replication of extrachromosomal circular DNA
intersection_of: GO:0001326 ! replication of extrachromosomal circular DNA
intersection_of: part_of GO:0001302 ! replicative cell aging
relationship: part_of GO:0001302 ! replicative cell aging
relationship: part_of GO:0001307 ! extrachromosomal circular DNA accumulation involved in replicative cell aging

[Term]
id: GO:0001315
name: age-dependent response to reactive oxygen species
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of reactive oxygen species, where the change varies according to the age of the cell or organism." [GOC:jh, PMID:12044938]
subset: gosubset_prok
synonym: "age-dependent response to active oxygen species" EXACT []
synonym: "age-dependent response to AOS" EXACT []
synonym: "age-dependent response to reactive oxidative species" EXACT []
synonym: "age-dependent response to reactive oxygen intermediate" EXACT []
synonym: "age-dependent response to ROI" EXACT []
synonym: "age-dependent response to ROS" EXACT []
is_a: GO:0000302 ! response to reactive oxygen species
is_a: GO:0001306 ! age-dependent response to oxidative stress

[Term]
id: GO:0001316
name: age-dependent response to reactive oxygen species involved in replicative cell aging
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring during the process of replicative cell aging as a result of reactive oxygen species, where the change varies according to the age of the cell or organism." [GOC:jh]
synonym: "age-dependent response to active oxygen species during replicative cell aging" RELATED []
synonym: "age-dependent response to AOS during replicative cell aging" EXACT []
synonym: "age-dependent response to reactive oxidative species during replicative cell aging" EXACT []
synonym: "age-dependent response to reactive oxygen intermediate during replicative cell aging" RELATED []
synonym: "age-dependent response to reactive oxygen species during replicative cell ageing" EXACT []
synonym: "age-dependent response to reactive oxygen species during replicative cell aging" RELATED [GOC:dph, GOC:tb]
synonym: "age-dependent response to ROI during replicative cell aging" RELATED []
synonym: "age-dependent response to ROS during replicative cell aging" RELATED []
is_a: GO:0001322 ! age-dependent response to oxidative stress involved in replicative cell aging
is_a: GO:0072353 ! cellular age-dependent response to reactive oxygen species

[Term]
id: GO:0001317
name: accumulation of oxidatively modified proteins involved in replicative cell aging
namespace: biological_process
def: "Accumulation of proteins that have undergone reactions with reactive oxygen species in aging dividing cells and exhibit modifications such as increased protein carbonyl content, oxidized methionine, protein hydrophobicity, and cross-linking." [GOC:jh]
synonym: "accumulation of oxidatively modified proteins during replicative cell ageing" RELATED []
synonym: "accumulation of oxidatively modified proteins during replicative cell aging" RELATED [GOC:dph, GOC:tb]
is_a: GO:0001316 ! age-dependent response to reactive oxygen species involved in replicative cell aging

[Term]
id: GO:0001318
name: formation of oxidatively modified proteins involved in replicative cell aging
namespace: biological_process
def: "Chemical reaction, between proteins and reactive oxygen species, that occurs in dividing cells as they age and leads to a variety of changes in the affected proteins, including increases in protein carbonyl content, oxidized methionine, protein hydrophobicity, and cross-linking." [GOC:jh]
synonym: "formation of oxidatively modified proteins during replicative cell ageing" RELATED []
synonym: "formation of oxidatively modified proteins during replicative cell aging" RELATED [GOC:dph, GOC:tb]
is_a: GO:0006464 ! cellular protein modification process
relationship: part_of GO:0001317 ! accumulation of oxidatively modified proteins involved in replicative cell aging

[Term]
id: GO:0001319
name: inheritance of oxidatively modified proteins involved in replicative cell aging
namespace: biological_process
def: "A protein localization process in which progeny cells acquire, or are barred from acquiring, proteins that have been altered by reaction with reactive oxygen species in dividing aging cells." [GOC:jh]
synonym: "inheritance of oxidatively modified proteins during replicative cell ageing" RELATED []
synonym: "inheritance of oxidatively modified proteins during replicative cell aging" RELATED [GOC:dph, GOC:tb]
is_a: GO:0008105 ! asymmetric protein localization
relationship: part_of GO:0001317 ! accumulation of oxidatively modified proteins involved in replicative cell aging

[Term]
id: GO:0001320
name: age-dependent response to reactive oxygen species involved in chronological cell aging
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring in non-dividing cells as they age as a result of reactive oxygen species, where the change varies according to the age of the cell or organism." [GOC:jh]
synonym: "age-dependent response to active oxygen species during chronological cell aging" RELATED []
synonym: "age-dependent response to AOS during chronological cell aging" RELATED []
synonym: "age-dependent response to reactive oxidative species during chronological cell aging" RELATED []
synonym: "age-dependent response to reactive oxygen intermediate during chronological cell aging" RELATED []
synonym: "age-dependent response to reactive oxygen species during chronological cell ageing" RELATED []
synonym: "age-dependent response to reactive oxygen species during chronological cell aging" RELATED [GOC:dph, GOC:tb]
synonym: "age-dependent response to ROI during chronological cell aging" RELATED []
synonym: "age-dependent response to ROS during chronological cell aging" RELATED []
is_a: GO:0001324 ! age-dependent response to oxidative stress involved in chronological cell aging
is_a: GO:0072353 ! cellular age-dependent response to reactive oxygen species
intersection_of: GO:0001315 ! age-dependent response to reactive oxygen species
intersection_of: part_of GO:0001300 ! chronological cell aging
relationship: part_of GO:0001300 ! chronological cell aging

[Term]
id: GO:0001321
name: age-dependent general metabolic decline involved in replicative cell aging
namespace: biological_process
def: "A process of general metabolic decline that arises in dividing cells as they age, and alters cellular metabolism to cause a decline in cell function." [GOC:jh, GOC:mah]
synonym: "age-dependent general metabolic decline during replicative cell ageing" RELATED []
synonym: "age-dependent general metabolic decline involved in replicative cell aging" RELATED [GOC:dph, GOC:tb]
is_a: GO:0007571 ! age-dependent general metabolic decline
intersection_of: GO:0007571 ! age-dependent general metabolic decline
intersection_of: part_of GO:0001302 ! replicative cell aging
relationship: part_of GO:0001302 ! replicative cell aging

[Term]
id: GO:0001322
name: age-dependent response to oxidative stress involved in replicative cell aging
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring in dividing cells as they age as a result of oxidative stress, where the change varies according to the age of the cell or organism." [GOC:jh]
synonym: "age-dependent response to oxidative stress during replicative cell ageing" RELATED []
synonym: "age-dependent response to oxidative stress during replicative cell aging" RELATED [GOC:dph, GOC:tb]
is_a: GO:0001306 ! age-dependent response to oxidative stress
intersection_of: GO:0001306 ! age-dependent response to oxidative stress
intersection_of: part_of GO:0001321 ! age-dependent general metabolic decline involved in replicative cell aging
relationship: part_of GO:0001321 ! age-dependent general metabolic decline involved in replicative cell aging
relationship: part_of GO:0034599 ! cellular response to oxidative stress

[Term]
id: GO:0001323
name: age-dependent general metabolic decline involved in chronological cell aging
namespace: biological_process
def: "A process of general metabolic decline that arises in non-dividing cells as they age, and alters cellular metabolism to cause a decline in cell function." [GOC:jh, GOC:mah]
synonym: "age-dependent general metabolic decline during chronological cell ageing" RELATED []
synonym: "age-dependent general metabolic decline during chronological cell aging" RELATED [GOC:dph, GOC:tb]
is_a: GO:0007571 ! age-dependent general metabolic decline
intersection_of: GO:0007571 ! age-dependent general metabolic decline
intersection_of: part_of GO:0001300 ! chronological cell aging
relationship: part_of GO:0001300 ! chronological cell aging

[Term]
id: GO:0001324
name: age-dependent response to oxidative stress involved in chronological cell aging
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring in non-dividing cells as they age as a result of oxidative stress, where the change varies according to the age of the cell or organism." [GOC:jh]
synonym: "age-dependent response to oxidative stress during chronological cell ageing" RELATED []
synonym: "age-dependent response to oxidative stress during chronological cell aging" RELATED [GOC:dph, GOC:tb]
is_a: GO:0001306 ! age-dependent response to oxidative stress
is_a: GO:0034599 ! cellular response to oxidative stress
intersection_of: GO:0001306 ! age-dependent response to oxidative stress
intersection_of: part_of GO:0001300 ! chronological cell aging
relationship: part_of GO:0001300 ! chronological cell aging
relationship: part_of GO:0001323 ! age-dependent general metabolic decline involved in chronological cell aging

[Term]
id: GO:0001325
name: formation of extrachromosomal circular DNA
namespace: biological_process
def: "Excision from the chromosome and circularization of a region of chromosomal DNA, generally, but not always, via homologous recombination between direct tandem repeats." [GOC:jh, PMID:12044938]
subset: gosubset_prok
synonym: "assembly of extrachromosomal circular DNA" EXACT []
is_a: GO:0006259 ! DNA metabolic process
is_a: GO:0022607 ! cellular component assembly

[Term]
id: GO:0001326
name: replication of extrachromosomal circular DNA
namespace: biological_process
def: "Replication of circular DNA following excision from the chromosome; replication of extrachromosomal circular DNA generally occurs independently of chromosomal replication." [GOC:jh]
subset: gosubset_prok
is_a: GO:0006260 ! DNA replication

[Term]
id: GO:0001400
name: mating projection base
namespace: cellular_component
def: "The region where the mating projection meets the bulk of the cell, in unicellular fungi exposed to mating pheromone." [GOC:mcc]
synonym: "base of shmoo tip" NARROW []
synonym: "conjugation tube base" NARROW []
is_a: GO:0044463 ! cell projection part
relationship: part_of GO:0005937 ! mating projection

[Term]
id: GO:0001401
name: mitochondrial sorting and assembly machinery complex
namespace: cellular_component
def: "A large complex of the mitochondrial outer membrane that mediates sorting of some imported proteins to the outer membrane and their assembly in the membrane; functions after import of incoming proteins by the mitochondrial outer membrane translocase complex." [PMID:12891361]
comment: See also the cellular component term 'mitochondrial outer membrane translocase complex ; GO:0005742'.
synonym: "SAM complex" EXACT []
synonym: "TOB complex" EXACT []
is_a: GO:0098799 ! outer mitochondrial membrane protein complex
relationship: part_of GO:0005741 ! mitochondrial outer membrane

[Term]
id: GO:0001402
name: signal transduction involved in filamentous growth
namespace: biological_process
def: "Relaying of environmental signals promoting filamentous growth." [GOC:mcc, PMID:9728395]
synonym: "MAPKKK cascade (pseudohyphal growth)" RELATED []
synonym: "signal transduction during filamentous growth" RELATED [GOC:dph, GOC:tb]
is_a: GO:0007165 ! signal transduction
intersection_of: GO:0007165 ! signal transduction
intersection_of: part_of GO:0030447 ! filamentous growth
relationship: part_of GO:0030447 ! filamentous growth

[Term]
id: GO:0001403
name: invasive growth in response to glucose limitation
namespace: biological_process
def: "A growth pattern exhibited by budding haploid cells under certain growth conditions, in which cells retain the typical axial budding pattern of haploids, but become elongated and fail to separate after division; during growth on a solid substrate, this results in penetration of cells into the agar medium. An example of this process is found in Saccharomyces cerevisiae." [GOC:mcc, PMID:9728395]
comment: Note that this term should not be used to describe the invasion of host tissues by pathogenic organisms, which is described by the biological process term 'entry into host ; GO:0044409', nor should it be used to describe growth of diseased cells of an organism into the surrounding normal tissue, which is outside of the scope of GO.
subset: goslim_yeast
synonym: "colony morphology" RELATED []
is_a: GO:0036267 ! invasive filamentous growth

[Term]
id: GO:0001404
name: obsolete invasive growth
namespace: biological_process
def: "OBSOLETE. Growth of a pathogenic organism that results in penetration into cells or tissues of the host organism. This often (but not necessarily) includes a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue." [GOC:mcc, PMID:9728395]
comment: This term was made obsolete because more appropriate terms were created.
synonym: "invasive growth" EXACT []
synonym: "tissue invasion" EXACT []
is_obsolete: true
consider: GO:0044409

[Term]
id: GO:0001405
name: presequence translocase-associated import motor
namespace: cellular_component
def: "Protein complex located on the matrix side of the mitochondrial inner membrane and associated with the presequence translocase complex; hydrolyzes ATP to provide the force to drive import of proteins into the mitochondrial matrix." [GOC:mcc, PMID:14517234, PMID:14638855]
synonym: "mitochondrial import motor" EXACT []
synonym: "PAM complex" EXACT []
synonym: "pre-sequence translocase-associated import motor" EXACT []
is_a: GO:0098800 ! inner mitochondrial membrane protein complex
relationship: part_of GO:0005744 ! mitochondrial inner membrane presequence translocase complex

[Term]
id: GO:0001406
name: glycerophosphodiester transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of glycerophosphodiesters from one side of a membrane to the other. Glycerophosphodiesters are small molecules composed of glycerol-3-phosphate and an alcohol, for example, glycerophosphoinositol." [GOC:mcc, PMID:12912892]
is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity
is_a: GO:1901505 ! carbohydrate derivative transporter activity
relationship: part_of GO:0001407 ! glycerophosphodiester transport

[Term]
id: GO:0001407
name: glycerophosphodiester transport
namespace: biological_process
def: "The directed movement of glycerophosphodiesters into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glycerophosphodiesters are small molecules composed of glycerol-3-phosphate and an alcohol, for example, glycerophosphoinositol." [GOC:mcc, PMID:12912892]
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015748 ! organophosphate ester transport
is_a: GO:1901264 ! carbohydrate derivative transport

[Term]
id: GO:0001408
name: guanine nucleotide transport
namespace: biological_process
def: "The directed movement of guanine nucleotides, GTP, GDP, and/or GMP, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mcc]
is_a: GO:0015858 ! nucleoside transport
is_a: GO:0015868 ! purine ribonucleotide transport

[Term]
id: GO:0001409
name: guanine nucleotide transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of guanine nucleotides (GMP, GDP, and GTP) from one side of the membrane to the other." [GOC:mcc]
is_a: GO:0015216 ! purine nucleotide transmembrane transporter activity
relationship: part_of GO:1903790 ! guanine nucleotide transmembrane transport

[Term]
id: GO:0001410
name: chlamydospore formation
namespace: biological_process
alt_id: GO:0055027
def: "The process whose specific outcome is the progression of the chlamydospore over time, from its formation to the mature structure. A chlamydospores is a mitotic (asexual) one-celled spore, produced primarily for survival, not dispersal, originating endogenously and singly within part of a pre-existing cell and possessing an inner secondary and often thickened cell wall. An example of this is found in Candida albicans." [GOC:mcc, GOC:mtg_sensu, ISBN:085199377X, PMID:14663094]
synonym: "chlamydospore development" EXACT []
is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore
is_a: GO:0048468 ! cell development

[Term]
id: GO:0001411
name: hyphal tip
namespace: cellular_component
def: "The end, or tip, of a fungal hypha, where polarized growth occurs during hyphal elongation." [GOC:mcc]
subset: goslim_candida
is_a: GO:0030427 ! site of polarized growth

[Term]
id: GO:0001501
name: skeletal system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton)." [GOC:dph, GOC:jid, GOC:tb, http://www.stedmans.com/]
synonym: "skeletal development" EXACT []
is_a: GO:0048731 ! system development

[Term]
id: GO:0001502
name: cartilage condensation
namespace: biological_process
def: "The condensation of mesenchymal cells that have been committed to differentiate into chondrocytes." [ISBN:0878932437]
is_a: GO:0098743 ! cell aggregation
relationship: part_of GO:0048705 ! skeletal system morphogenesis
relationship: part_of GO:0051216 ! cartilage development

[Term]
id: GO:0001503
name: ossification
namespace: biological_process
def: "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:mtg_mpo, PMID:17572649]
comment: Note that this term does not have a 'developmental process' parent because ossification isn't necessarily developmental, can also occur as part of bone remodeling. Instead use 'ossification involved in bone maturation ; GO:0043931'.
synonym: "bone biosynthesis" EXACT []
synonym: "bone formation" EXACT []
synonym: "osteogenesis" EXACT []
xref: Wikipedia:Ossification
is_a: GO:0044707 ! single-multicellular organism process

[Term]
id: GO:0001504
name: neurotransmitter uptake
namespace: biological_process
def: "The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters." [ISBN:0123668387]
subset: goslim_synapse
synonym: "neurotransmitter import" EXACT [GOC:dph, GOC:tb]
synonym: "neurotransmitter import into glial cell" NARROW []
synonym: "neurotransmitter import into neuron" NARROW []
synonym: "neurotransmitter recycling" BROAD []
xref: Reactome:REACT_106095 "Neurotransmitter uptake and Metabolism In Glial Cells, Gallus gallus"
xref: Reactome:REACT_106673 "Neurotransmitter uptake and Metabolism In Glial Cells, Bos taurus"
xref: Reactome:REACT_107830 "Neurotransmitter uptake and Metabolism In Glial Cells, Arabidopsis thaliana"
xref: Reactome:REACT_114027 "Neurotransmitter uptake and Metabolism In Glial Cells, Staphylococcus aureus N315"
xref: Reactome:REACT_13594 "Neurotransmitter uptake and Metabolism In Glial Cells, Homo sapiens"
xref: Reactome:REACT_29399 "Neurotransmitter uptake and Metabolism In Glial Cells, Drosophila melanogaster"
xref: Reactome:REACT_30311 "Neurotransmitter uptake and Metabolism In Glial Cells, Rattus norvegicus"
xref: Reactome:REACT_82534 "Neurotransmitter uptake and Metabolism In Glial Cells, Caenorhabditis elegans"
xref: Reactome:REACT_88126 "Neurotransmitter uptake and Metabolism In Glial Cells, Escherichia coli"
xref: Reactome:REACT_89424 "Neurotransmitter uptake and Metabolism In Glial Cells, Sus scrofa"
xref: Reactome:REACT_92363 "Neurotransmitter uptake and Metabolism In Glial Cells, Canis familiaris"
xref: Reactome:REACT_93291 "Neurotransmitter uptake and Metabolism In Glial Cells, Taeniopygia guttata"
xref: Reactome:REACT_94616 "Neurotransmitter uptake and Metabolism In Glial Cells, Schizosaccharomyces pombe"
xref: Reactome:REACT_97761 "Neurotransmitter uptake and Metabolism In Glial Cells, Saccharomyces cerevisiae"
xref: Reactome:REACT_98224 "Neurotransmitter uptake and Metabolism In Glial Cells, Oryza sativa"
xref: Reactome:REACT_98482 "Neurotransmitter uptake and Metabolism In Glial Cells, Xenopus tropicalis"
xref: Reactome:REACT_98978 "Neurotransmitter uptake and Metabolism In Glial Cells, Danio rerio"
xref: Reactome:REACT_99735 "Neurotransmitter uptake and Metabolism In Glial Cells, Mus musculus"
is_a: GO:0001505 ! regulation of neurotransmitter levels
is_a: GO:0006836 ! neurotransmitter transport
is_a: GO:0098657 ! import into cell

[Term]
id: GO:0001505
name: regulation of neurotransmitter levels
namespace: biological_process
def: "Any process that modulates levels of neurotransmitter." [GOC:jl]
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0001506
name: obsolete neurotransmitter biosynthetic process and storage
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of neurotransmitters and the storage of the synthesized molecules." [GOC:go_curators, ISBN:0123668387]
comment: This term was made obsolete because it is an amalgamation of its two children.
synonym: "neurotransmitter anabolism and storage" EXACT []
synonym: "neurotransmitter biosynthetic process and storage" EXACT []
synonym: "neurotransmitter formation and storage" EXACT []
synonym: "neurotransmitter synthesis and storage" EXACT []
is_obsolete: true
consider: GO:0042136
consider: GO:0042137

[Term]
id: GO:0001507
name: acetylcholine catabolic process in synaptic cleft
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of acetylcholine that occurs in the synaptic cleft during synaptic transmission." [GOC:ai]
synonym: "acetylcholine breakdown in synaptic cleft" EXACT []
synonym: "acetylcholine degradation in synaptic cleft" EXACT []
is_a: GO:0006581 ! acetylcholine catabolic process
intersection_of: GO:0006581 ! acetylcholine catabolic process
intersection_of: occurs_in GO:0043083 ! synaptic cleft
relationship: occurs_in GO:0043083 ! synaptic cleft
relationship: part_of GO:0007271 ! synaptic transmission, cholinergic

[Term]
id: GO:0001508
name: action potential
namespace: biological_process
def: "A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities." [GOC:dph, GOC:go_curators, GOC:tb, ISBN:978-0-07-139011-8]
comment: Action potentials typically propagate across excitable membranes. This class covers both action potentials that propagate and those that fail to do so.
is_a: GO:0042391 ! regulation of membrane potential

[Term]
id: GO:0001509
name: obsolete legumain activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of proteins and small-molecule substrates at Asn-Xaa bonds." [EC:3.4.22.34]
comment: This term was made obsolete because it represents a gene product.
synonym: "asparaginyl endopeptidase activity" RELATED [EC:3.4.22.34]
synonym: "bean endopeptidase activity" RELATED [EC:3.4.22.34]
synonym: "citvac" RELATED [EC:3.4.22.34]
synonym: "hemoglobinase activity" RELATED [EC:3.4.22.34]
synonym: "legumain activity" EXACT []
synonym: "phaseolin activity" RELATED [EC:3.4.22.34]
synonym: "proteinase B" RELATED [EC:3.4.22.34]
synonym: "PRSC1 gene product (Homo sapiens)" RELATED [EC:3.4.22.34]
synonym: "vicilin peptidohydrolase activity" RELATED [EC:3.4.22.34]
xref: EC:3.4.22.34
xref: MetaCyc:3.4.22.34-RXN
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0001510
name: RNA methylation
namespace: biological_process
def: "Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor." [GOC:hjd]
subset: gosubset_prok
is_a: GO:0009451 ! RNA modification
is_a: GO:0043414 ! macromolecule methylation

[Term]
id: GO:0001511
name: obsolete fibrillin
namespace: molecular_function
def: "OBSOLETE. Large glycoprotein that is a calcium binding component of connective tissue microfibrils containing 34 six-cysteine (EGF-like) repeats and five eight-cysteine (TGFbeta-1 binding protein-like) repeats. Defects associated with Marfan syndrome." [ISBN:0198506732]
comment: This term was made obsolete because it represents a gene product.
synonym: "fibrillin" EXACT []
is_obsolete: true
consider: GO:0001527
consider: GO:0005509

[Term]
id: GO:0001512
name: dihydronicotinamide riboside quinone reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone = 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone." [EC:1.10.99.2]
synonym: "1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide:quinone oxidoreductase activity" EXACT [EC:1.10.99.2]
synonym: "N-ribosyldihydronicotinamide dehydrogenase (quinone) activity" EXACT [EC:1.10.99.2]
synonym: "NAD(P)H:quinone oxidoreductase 2 activity" EXACT [EC:1.10.99.2]
synonym: "NAD(P)H:quinone oxidoreductase-2" RELATED [EC:1.10.99.2]
synonym: "NAD(P)H:quinone oxidoreductase2" RELATED [EC:1.10.99.2]
synonym: "NQO(2) activity" EXACT [EC:1.10.99.2]
synonym: "NQO2" RELATED [EC:1.10.99.2]
synonym: "NRH:quinone oxidoreductase 2 activity" NARROW [EC:1.10.99.2]
synonym: "QR2 activity" RELATED [EC:1.10.99.2]
synonym: "quinone reductase 2 activity" RELATED [EC:1.10.99.2]
synonym: "ribosyldihydronicotinamide dehydrogenase (quinone) activity" EXACT []
xref: EC:1.10.99.2
xref: MetaCyc:1.10.99.2-RXN
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0001514
name: selenocysteine incorporation
namespace: biological_process
def: "The incorporation of selenocysteine into a peptide; uses a special tRNA that recognizes the UGA codon as selenocysteine, rather than as a termination codon. Selenocysteine is synthesized from serine before its incorporation; it is not a posttranslational modification of peptidyl-cysteine." [RESID:AA0022]
subset: gosubset_prok
xref: RESID:AA0022
is_a: GO:0006451 ! translational readthrough

[Term]
id: GO:0001515
name: opioid peptide activity
namespace: molecular_function
def: "Naturally occurring peptide that is an opioid (any non-alkaloid having an opiate-like effect that can be reversed by naloxone or other recognized morphine antagonist). These include Leu- and Met-enkephalin, dynorphin and neoendorphin, alpha, beta, gamma and delta endorphins formed from beta-lipotropin, various pronase-resistant peptides such as beta casamorphin, and other peptides whose opiate-like action seems to be indirect." [ISBN:0198506732]
subset: goslim_chembl
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0001516
name: prostaglandin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring." [GOC:ai]
subset: gosubset_prok
synonym: "prostaglandin anabolism" EXACT []
synonym: "prostaglandin biosynthesis" EXACT []
synonym: "prostaglandin formation" EXACT []
synonym: "prostaglandin synthesis" EXACT []
is_a: GO:0006693 ! prostaglandin metabolic process
is_a: GO:0046457 ! prostanoid biosynthetic process

[Term]
id: GO:0001517
name: N-acetylglucosamine 6-O-sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-glucosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-glucosamine 6-sulfate." [GOC:ai, GOC:hjd]
subset: goslim_chembl
synonym: "N-acetylglucosamine 6-O-sulphotransferase activity" EXACT []
xref: EC:2.8.2.-
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0001518
name: voltage-gated sodium channel complex
namespace: cellular_component
def: "A sodium channel in a cell membrane whose opening is governed by the membrane potential." [ISBN:0198506732]
synonym: "voltage gated sodium channel complex" EXACT []
synonym: "voltage-dependent sodium channel complex" EXACT []
synonym: "voltage-sensitive sodium channel complex" EXACT []
xref: NIF_Subcellular:sao785001660
is_a: GO:0034706 ! sodium channel complex
is_a: GO:0098797 ! plasma membrane protein complex
relationship: part_of GO:0005887 ! integral component of plasma membrane

[Term]
id: GO:0001519
name: peptide amidation
namespace: biological_process
def: "The posttranslational conversion of C-terminal glycine-extended peptides to C-terminal alpha-amidated peptides. Occurs to over half of all peptide hormones to give bioactive peptides. This is a two step process catalyzed by a peptidyl-glycine alpha-hydroxylating monooxygenase and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase. In some organisms, this process is catalyzed by two separate enzymes, whereas in higher organisms, one polypeptide catalyzes both reactions." [PMID:11028916]
subset: gosubset_prok
is_a: GO:0031179 ! peptide modification

[Term]
id: GO:0001520
name: outer dense fiber
namespace: cellular_component
def: "A supramolecular fiber found in the flagella of mammalian sperm that surrounds the nine microtubule doublets. These dense fibers are stiff and noncontractile. In human, they consist of about 10 major and at least 15 minor proteins, where all major proteins are ODF1, ODF2 or ODF2-related proteins." [GOC:cilia, GOC:krc, ISBN:0824072820, PMID:10381817, PMID:21586547, PMID:25361759]
synonym: "outer dense fibre" EXACT []
is_a: GO:0044441 ! ciliary part
is_a: GO:0097223 ! sperm part
is_a: GO:0099512 ! supramolecular fiber
relationship: part_of GO:0036126 ! sperm flagellum

[Term]
id: GO:0001522
name: pseudouridine synthesis
namespace: biological_process
def: "The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs." [GOC:hjd, GOC:mah]
subset: gosubset_prok
synonym: "pseudouridylation" EXACT []
xref: Wikipedia:Pseudouridine
xref: Wikipedia:Pseudouridylation
is_a: GO:0009451 ! RNA modification

[Term]
id: GO:0001523
name: retinoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity." [ISBN:0198506732]
subset: gosubset_prok
synonym: "retinoid metabolism" EXACT []
xref: Reactome:REACT_24968 "Vitamin A uptake in enterocytes, Homo sapiens"
is_a: GO:0016101 ! diterpenoid metabolic process

[Term]
id: GO:0001524
name: obsolete globin
namespace: molecular_function
def: "OBSOLETE. The colorless and basic protein moiety of hemoglobin and myoglobins." [GOC:ai, ISBN:0198506732]
comment: This term was made obsolete because it represents a gene product.
synonym: "globin" EXACT []
is_obsolete: true
replaced_by: GO:0005344

[Term]
id: GO:0001525
name: angiogenesis
namespace: biological_process
def: "Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels." [ISBN:0878932453]
synonym: "blood vessel formation from pre-existing blood vessels" EXACT systematic_synonym []
xref: Wikipedia:Angiogenesis
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0048514 ! blood vessel morphogenesis

[Term]
id: GO:0001526
name: obsolete proteoglycan sulfate transfer
namespace: biological_process
def: "OBSOLETE. Transfer of sulfate to a proteoglycan (a glycoprotein whose carbohydrate units are glycosaminoglycans) using 3'-phosphoadenyl sulfate." [GOC:hjd]
comment: This term was made obsolete because it represents a group of molecular functions.
synonym: "proteoglycan sulfate transfer" EXACT []
synonym: "proteoglycan sulphate transfer" EXACT []
is_obsolete: true
consider: GO:0006029
consider: GO:0006790
consider: GO:0050698

[Term]
id: GO:0001527
name: microfibril
namespace: cellular_component
def: "Extracellular matrix components occurring independently or along with elastin. Thought to have force-bearing functions in tendon. In addition to fibrillins, microfibrils may contain other associated proteins." [http://www.xrefer.com/entry/490235]
synonym: "extended fibrils" EXACT []
synonym: "fibrillin" RELATED []
is_a: GO:0043205 ! fibril

[Term]
id: GO:0001528
name: obsolete elastin
namespace: molecular_function
def: "OBSOLETE. A major structural protein of mammalian connective tissues; composed of one third glycine, and also rich in proline, alanine, and valine. Chains are cross-linked together via lysine residues." [ISBN:0198506732]
comment: This term was made obsolete because it represents a gene product.
synonym: "elastin" EXACT []
is_obsolete: true
replaced_by: GO:0030023

[Term]
id: GO:0001529
name: obsolete elastin
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "elastin" EXACT []
is_obsolete: true
replaced_by: GO:0030023

[Term]
id: GO:0001530
name: lipopolysaccharide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with lipopolysaccharide." [PMID:11079463]
synonym: "endotoxin binding" BROAD []
synonym: "LPS binding" EXACT []
is_a: GO:0008289 ! lipid binding
is_a: GO:0097367 ! carbohydrate derivative binding

[Term]
id: GO:0001531
name: interleukin-21 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-21 receptor." [GOC:ai]
synonym: "IL-21" NARROW []
synonym: "interleukin-21 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0001532
name: interleukin-21 receptor activity
namespace: molecular_function
def: "Combining with interleukin-21 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
synonym: "IL-21 receptor activity" EXACT [GOC:mah]
synonym: "IL-21R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity
relationship: has_part GO:0019977 ! interleukin-21 binding
relationship: part_of GO:0038114 ! interleukin-21-mediated signaling pathway

[Term]
id: GO:0001533
name: cornified envelope
namespace: cellular_component
def: "A type of plasma membrane that has been modified through addition of distinct intracellular and extracellular components, including ceramide, found in cornifying epithelial cells (corneocytes)." [GOC:add, PMID:11112355, PMID:11590230, PMID:15803139]
is_a: GO:0005886 ! plasma membrane

[Term]
id: GO:0001534
name: radial spoke
namespace: cellular_component
def: "Protein complex that links the outer microtubule doublet of the ciliary or flagellum axoneme with the sheath that surrounds the central pair of microtubules. Composed of a stalk that attaches to each doublet microtubule and a globular structure (spoke head) that projects toward the central pair of microtubules." [ISBN:0124325653, PMID:9450971]
subset: goslim_pir
xref: Wikipedia:Radial_spoke
is_a: GO:0043234 ! protein complex
is_a: GO:0044447 ! axoneme part

[Term]
id: GO:0001535
name: radial spokehead
namespace: cellular_component
def: "Protein complex forming part of eukaryotic flagellar apparatus." [GOC:hjd]
is_a: GO:0043234 ! protein complex
is_a: GO:0044447 ! axoneme part
relationship: part_of GO:0001534 ! radial spoke

[Term]
id: GO:0001536
name: radial spoke stalk
namespace: cellular_component
def: "Globular portion of the radial spoke that projects towards the central pair of microtubules." [GOC:hjd]
is_a: GO:0043234 ! protein complex
is_a: GO:0044447 ! axoneme part
relationship: part_of GO:0001534 ! radial spoke

[Term]
id: GO:0001537
name: N-acetylgalactosamine 4-O-sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-galactosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-galactosamine 4-sulfate." [EC:2.8.2.-, GOC:ai]
synonym: "N-acetylgalactosamine 4-O-sulphotransferase activity" EXACT []
xref: EC:2.8.2.-
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0001539
name: cilium or flagellum-dependent cell motility
namespace: biological_process
def: "Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella." [GOC:cilia, GOC:hjd, GOC:krc]
comment: Note that we deem eukaryotic cilia and microtubule-based flagella to be equivalent, while the bacterial- and archaeal-type flagella have a different structure. The former are microtubule-based structures that lash back and forth and are present only in eukaryotes, while the latter achieve motility by rotation. Bacterial- and archaeal-type flagella are superficially similar but have a different molecular composition and fine structure. These three structures never co-exist in the same organism. Therefore, GO:0001539 'cilium or flagellum-dependent cell motility' is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term. Direct annotations to GO:0001539 'cilium or flagellum-dependent cell motility' may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
subset: gosubset_prok
synonym: "ciliary or bacterial-type flagellar motility" RELATED []
synonym: "ciliary/flagellar motility" EXACT []
is_a: GO:0048870 ! cell motility

[Term]
id: GO:0001540
name: beta-amyloid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with beta-amyloid peptide/protein and/or its precursor." [GOC:hjd]
subset: goslim_chembl
is_a: GO:0042277 ! peptide binding

[Term]
id: GO:0001541
name: ovarian follicle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure." [GOC:go_curators]
synonym: "follicular phase" RELATED []
is_a: GO:0022602 ! ovulation cycle process
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048608 ! reproductive structure development
relationship: part_of GO:0008585 ! female gonad development

[Term]
id: GO:0001542
name: ovulation from ovarian follicle
namespace: biological_process
def: "The process leading to the rupture of the follicle, releasing the centrally located oocyte into the oviduct. An example of this is found in Mus musculus." [GOC:mtg_sensu, http://ovary.stanford.edu]
is_a: GO:0022602 ! ovulation cycle process
is_a: GO:0030728 ! ovulation
relationship: part_of GO:0008585 ! female gonad development

[Term]
id: GO:0001543
name: ovarian follicle rupture
namespace: biological_process
def: "Disruption of theca cell layer releasing follicular fluid and/or the oocyte." [http://ovary.stanford.edu]
is_a: GO:0022602 ! ovulation cycle process
relationship: part_of GO:0001542 ! ovulation from ovarian follicle

[Term]
id: GO:0001544
name: initiation of primordial ovarian follicle growth
namespace: biological_process
def: "Increase in size of primordial follicles including proliferation and shape changes of granulosa and/or theca cells until oocyte is surrounded by one layer of cuboidal shaped granulosa cells (primary follicle)." [http://ovary.stanford.edu]
is_a: GO:0022602 ! ovulation cycle process
relationship: part_of GO:0001541 ! ovarian follicle development

[Term]
id: GO:0001545
name: primary ovarian follicle growth
namespace: biological_process
def: "Increase in size of primary follicles including oocyte growth and granulosa and/or theca cell proliferation until more than one layer of granulosa cells is present (preantral follicle)." [GOC:mtg_mpo, http://ovary.stanford.edu]
is_a: GO:0022602 ! ovulation cycle process
is_a: GO:0040007 ! growth
relationship: part_of GO:0001541 ! ovarian follicle development

[Term]
id: GO:0001546
name: preantral ovarian follicle growth
namespace: biological_process
def: "Increase in size of follicles surrounded by two or more layers of granulosa cells up to the onset of antrum formation." [http://ovary.stanford.edu]
is_a: GO:0022602 ! ovulation cycle process
is_a: GO:0040007 ! growth
relationship: part_of GO:0001541 ! ovarian follicle development
relationship: part_of GO:0048162 ! multi-layer follicle stage

[Term]
id: GO:0001547
name: antral ovarian follicle growth
namespace: biological_process
def: "Increase in size of antral follicles due to cell proliferation and/or growth of the antral cavity." [http://ovary.stanford.edu]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0022602 ! ovulation cycle process
is_a: GO:0048589 ! developmental growth
relationship: part_of GO:0001541 ! ovarian follicle development

[Term]
id: GO:0001548
name: follicular fluid formation in ovarian follicle antrum
namespace: biological_process
def: "The menstrual cycle process that results in the formation of one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells during the various stages of oogenesis." [GOC:dph, GOC:tb, http://ovary.stanford.edu]
synonym: "ovarian follicle antrum/follicular fluid biosynthesis" EXACT []
synonym: "ovarian follicle antrum/follicular fluid formation" EXACT []
is_a: GO:0022602 ! ovulation cycle process
relationship: part_of GO:0001547 ! antral ovarian follicle growth

[Term]
id: GO:0001549
name: cumulus cell differentiation
namespace: biological_process
def: "The process in which a subpopulation of granulosa cells surrounding the oocyte acquires the specialized features of an ovarian cumulus cell." [http://ovary.stanford.edu]
synonym: "ovarian cumulus cell differentiation" EXACT []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0022602 ! ovulation cycle process
is_a: GO:0030855 ! epithelial cell differentiation
relationship: part_of GO:0001547 ! antral ovarian follicle growth
relationship: part_of GO:0048165 ! fused antrum stage

[Term]
id: GO:0001550
name: ovarian cumulus expansion
namespace: biological_process
def: "Increase in size of the cumulus surrounding the oocyte including change in morphology due to proliferation and dispersion of cumulus cells." [http://ovary.stanford.edu]
synonym: "ovarian cumulus growth" RELATED []
is_a: GO:0022602 ! ovulation cycle process
is_a: GO:0040007 ! growth
relationship: part_of GO:0001547 ! antral ovarian follicle growth
relationship: part_of GO:0048165 ! fused antrum stage

[Term]
id: GO:0001551
name: ovarian follicle endowment
namespace: biological_process
def: "Association of oocytes with supporting epithelial granulosa cells to form primordial follicles." [http://ovary.stanford.edu]
is_a: GO:0022602 ! ovulation cycle process
relationship: part_of GO:0001541 ! ovarian follicle development

[Term]
id: GO:0001552
name: ovarian follicle atresia
namespace: biological_process
def: "A periodic process in which immature ovarian follicles degenerate and are subsequently re-absorbed." [GOC:mtg_apoptosis, http://ovary.stanford.edu, PMID:18638134]
is_a: GO:0003006 ! developmental process involved in reproduction
relationship: has_part GO:0097191 ! extrinsic apoptotic signaling pathway
relationship: part_of GO:0008585 ! female gonad development

[Term]
id: GO:0001553
name: luteinization
namespace: biological_process
def: "The set of processes resulting in differentiation of theca and granulosa cells into luteal cells and in the formation of a corpus luteum after ovulation." [http://ovary.stanford.edu]
synonym: "luteal phase" RELATED []
xref: Wikipedia:Luteal_phase
xref: Wikipedia:Luteinization
is_a: GO:0022602 ! ovulation cycle process
relationship: part_of GO:0008585 ! female gonad development

[Term]
id: GO:0001554
name: luteolysis
namespace: biological_process
def: "The lysis or structural demise of the corpus luteum. During normal luteolysis, two closely related events occur. First, there is loss of the capacity to synthesize and secrete progesterone (functional luteolysis) followed by loss of the cells that comprise the corpus luteum (structural luteolysis). Preventing luteolysis is crucial to maintain pregnancy." [http://ovary.stanford.edu, PMID:10617764]
xref: Wikipedia:Luteolysis
is_a: GO:0022602 ! ovulation cycle process
relationship: part_of GO:0008585 ! female gonad development

[Term]
id: GO:0001555
name: oocyte growth
namespace: biological_process
def: "The developmental growth process in which an oocyte irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [http://ovary.stanford.edu]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0048588 ! developmental cell growth
relationship: part_of GO:0048599 ! oocyte development

[Term]
id: GO:0001556
name: oocyte maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization." [GOC:devbiol, http://ovary.stanford.edu]
xref: Wikipedia:Oocyte_maturation
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0048469 ! cell maturation
relationship: part_of GO:0048599 ! oocyte development

[Term]
id: GO:0001557
name: obsolete metabolic process resulting in cell growth
namespace: biological_process
def: "OBSOLETE. The chemical reactions that occur in living organisms that result in an increase in the mass (size) of a cell." [GOC:dph]
comment: This term was made obsolete as part of the metabolism rearrangements, because it is redundant with other terms.
synonym: "metabolic process resulting in cell growth" EXACT []
is_obsolete: true
consider: GO:0008152
consider: GO:0016049

[Term]
id: GO:0001558
name: regulation of cell growth
namespace: biological_process
def: "Any process that modulates the frequency, rate, extent or direction of cell growth." [GOC:go_curators]
subset: gosubset_prok
xref: Reactome:REACT_6201 "DTOR is positively regulated by DRheb-GTP, Drosophila melanogaster"
is_a: GO:0040008 ! regulation of growth
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016049 ! cell growth
relationship: regulates GO:0016049 ! cell growth

[Term]
id: GO:0001559
name: regulation of cell growth by detection of nuclear:cytoplasmic ratio
namespace: biological_process
def: "Any process in which the size of the nucleus with respect to the cytoplasm modulates the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time." [GOC:dph]
synonym: "detection of nuclear:cytoplasmic ratio to regulate cell growth" EXACT []
synonym: "interpretation of nuclear:cytoplasmic ratio to regulate cell growth" EXACT []
synonym: "regulation of cell growth by nuclear:cytoplasmic ratio" EXACT []
synonym: "regulation of cell growth by sensing of nuclear:cytoplasmic ratio" EXACT []
is_a: GO:0016475 ! detection of nuclear:cytoplasmic ratio
is_a: GO:0061387 ! regulation of extent of cell growth
intersection_of: GO:0016475 ! detection of nuclear:cytoplasmic ratio
intersection_of: regulates GO:0016049 ! cell growth
relationship: regulates GO:0016049 ! cell growth

[Term]
id: GO:0001560
name: regulation of cell growth by extracellular stimulus
namespace: biological_process
def: "Any process in which external signals modulate the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time." [GOC:dph]
synonym: "interpretation of external signals that regulate cell growth" EXACT []
synonym: "regulation of cell growth by detection of exogenous stimulus" EXACT []
synonym: "regulation of cell growth by sensing of exogenous stimulus" EXACT []
synonym: "regulation of growth by exogenous signal" EXACT []
synonym: "regulation of growth by exogenous stimuli" EXACT []
synonym: "regulation of growth by exogenous stimulus" EXACT []
synonym: "regulation of growth by external signal" EXACT []
synonym: "regulation of growth by external stimuli" EXACT []
synonym: "regulation of growth by external stimulus" EXACT []
is_a: GO:0001558 ! regulation of cell growth
intersection_of: GO:0001558 ! regulation of cell growth
intersection_of: part_of GO:0031668 ! cellular response to extracellular stimulus
relationship: part_of GO:0031668 ! cellular response to extracellular stimulus

[Term]
id: GO:0001561
name: fatty acid alpha-oxidation
namespace: biological_process
def: "A metabolic pathway by which 3-methyl branched fatty acids are degraded. These compounds are not degraded by the normal peroxisomal beta-oxidation pathway, because the 3-methyl blocks the dehydrogenation of the hydroxyl group by hydroxyacyl-CoA dehydrogenase. The 3-methyl branched fatty acid is converted in several steps to pristenic acid, which can then feed into the beta-oxidative pathway." [http://www.peroxisome.org/Scientist/Biochemistry/alpha-oxidation.html]
subset: gosubset_prok
xref: MetaCyc:PWY-2501
xref: Reactome:REACT_103076 "Alpha-oxidation of phytanate, Dictyostelium discoideum"
xref: Reactome:REACT_106518 "Alpha-oxidation of phytanate, Drosophila melanogaster"
xref: Reactome:REACT_106956 "Alpha-oxidation of phytanate, Mus musculus"
xref: Reactome:REACT_107335 "Alpha-oxidation of phytanate, Taeniopygia guttata"
xref: Reactome:REACT_109097 "Alpha-oxidation of phytanate, Saccharomyces cerevisiae"
xref: Reactome:REACT_17003 "Alpha-oxidation of phytanate, Homo sapiens"
xref: Reactome:REACT_29885 "Alpha-oxidation of phytanate, Oryza sativa"
xref: Reactome:REACT_47735 "Alpha-oxidation of phytanate, Gallus gallus"
xref: Reactome:REACT_78088 "Alpha-oxidation of phytanate, Bos taurus"
xref: Reactome:REACT_81097 "Alpha-oxidation of phytanate, Xenopus tropicalis"
xref: Reactome:REACT_83317 "Alpha-oxidation of phytanate, Caenorhabditis elegans"
xref: Reactome:REACT_87622 "Alpha-oxidation of phytanate, Sus scrofa"
xref: Reactome:REACT_87835 "Alpha-oxidation of phytanate, Arabidopsis thaliana"
xref: Reactome:REACT_90750 "Alpha-oxidation of phytanate, Canis familiaris"
xref: Reactome:REACT_92361 "Alpha-oxidation of phytanate, Mycobacterium tuberculosis"
xref: Reactome:REACT_94726 "Alpha-oxidation of phytanate, Escherichia coli"
xref: Reactome:REACT_94872 "Alpha-oxidation of phytanate, Rattus norvegicus"
xref: Reactome:REACT_96409 "Alpha-oxidation of phytanate, Danio rerio"
xref: Reactome:REACT_98637 "Alpha-oxidation of phytanate, Schizosaccharomyces pombe"
is_a: GO:0009062 ! fatty acid catabolic process
is_a: GO:0019395 ! fatty acid oxidation

[Term]
id: GO:0001562
name: response to protozoan
namespace: biological_process
alt_id: GO:0042833
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a protozoan." [GOC:ai]
synonym: "resistance to pathogenic protozoa" RELATED []
synonym: "response to protozoa" EXACT []
synonym: "response to protozoon" EXACT []
is_a: GO:0051707 ! response to other organism

[Term]
id: GO:0001563
name: detection of protozoan
namespace: biological_process
def: "The series of events in which a stimulus from a protozoan is received and converted into a molecular signal." [GOC:ai]
synonym: "detection of protozoa" EXACT []
synonym: "detection of protozoon" EXACT []
synonym: "perception of protozoa" RELATED []
is_a: GO:0001562 ! response to protozoan
is_a: GO:0098543 ! detection of other organism

[Term]
id: GO:0001564
name: obsolete resistance to pathogenic protozoa
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process.
synonym: "resistance to pathogenic protozoa" EXACT []
is_obsolete: true
replaced_by: GO:0001562

[Term]
id: GO:0001565
name: phorbol ester receptor activity
namespace: molecular_function
def: "Combining with a phorbol ester and transmitting the signal to initiate a change in cell activity." [GOC:ai, GOC:signaling, PMID:10506570]
is_a: GO:0038023 ! signaling receptor activity

[Term]
id: GO:0001566
name: non-kinase phorbol ester receptor activity
namespace: molecular_function
def: "Combining with a phorbol ester and transmitting the signal by a mechanism independent of kinase activity." [PMID:10506570]
is_a: GO:0001565 ! phorbol ester receptor activity

[Term]
id: GO:0001567
name: cholesterol 25-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: AH(2) + cholesterol + O(2) = 25-hydroxycholesterol + A + H(2)O." [EC:1.14.99.38, RHEA:21107]
synonym: "cholesterol 25-monooxygenase activity" EXACT [EC:1.14.99.38]
synonym: "cholesterol,hydrogen-donor:oxygen oxidoreductase (25-hydroxylating) activity" EXACT [EC:1.14.99.38]
xref: EC:1.14.99.38
xref: KEGG:R07218
xref: MetaCyc:1.14.99.38-RXN
xref: RHEA:21107
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0001568
name: blood vessel development
namespace: biological_process
def: "The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood." [GOC:hjd, UBERON:0001981]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0001944 ! vasculature development

[Term]
id: GO:0001569
name: patterning of blood vessels
namespace: biological_process
def: "The process that regulates the coordinated growth and sprouting of blood vessels giving rise to the organized vascular system." [GOC:dph]
synonym: "branching involved in blood vessel morphogenesis" EXACT [GOC:dph]
is_a: GO:0007389 ! pattern specification process
is_a: GO:0048754 ! branching morphogenesis of an epithelial tube
relationship: part_of GO:0001525 ! angiogenesis

[Term]
id: GO:0001570
name: vasculogenesis
namespace: biological_process
def: "The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes." [PMID:8999798]
synonym: "vascular morphogenesis" EXACT []
xref: Wikipedia:Vasculogenesis
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0048514 ! blood vessel morphogenesis

[Term]
id: GO:0001571
name: non-tyrosine kinase fibroblast growth factor receptor activity
namespace: molecular_function
def: "Combining with fibroblast growth factor (FGF) and transmitting the signal from one side of the membrane to the other by a mechanism independent of tyrosine kinase activity." [GOC:signaling, PMID:11418238]
synonym: "non-tyrosine kinase FGF receptor activity" EXACT []
synonym: "non-tyrosine kinase FGFR activity" EXACT []
is_a: GO:0004888 ! transmembrane signaling receptor activity

[Term]
id: GO:0001572
name: lactosylceramide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lactosylceramides, Gal-beta-(1->4)-Glc-beta(1->1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group. They are the precursors of both gangliosides and globosides." [ISBN:0198506732, ISBN:0471586501]
subset: gosubset_prok
synonym: "lactosylceramide anabolism" EXACT []
synonym: "lactosylceramide biosynthesis" EXACT []
synonym: "lactosylceramide formation" EXACT []
synonym: "lactosylceramide synthesis" EXACT []
is_a: GO:0006688 ! glycosphingolipid biosynthetic process
is_a: GO:0046478 ! lactosylceramide metabolic process
is_a: GO:0046513 ! ceramide biosynthetic process

[Term]
id: GO:0001573
name: ganglioside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues." [ISBN:0198506732]
subset: gosubset_prok
synonym: "ganglioside metabolism" EXACT []
is_a: GO:0006672 ! ceramide metabolic process
is_a: GO:0006687 ! glycosphingolipid metabolic process

[Term]
id: GO:0001574
name: ganglioside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues." [ISBN:0198506732]
subset: gosubset_prok
synonym: "ganglioside anabolism" EXACT []
synonym: "ganglioside biosynthesis" EXACT []
synonym: "ganglioside formation" EXACT []
synonym: "ganglioside synthesis" EXACT []
is_a: GO:0001573 ! ganglioside metabolic process
is_a: GO:0006688 ! glycosphingolipid biosynthetic process
is_a: GO:0046513 ! ceramide biosynthetic process

[Term]
id: GO:0001575
name: globoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving globosides, globotetraosylceramides, ceramides containing a core structure of GalNAc-beta-(1->3)-Gal-alpha-(1->4)-Glc(I). Globosides are the major neutral glycosphingolipid in normal kidneys and erythrocytes." [ISBN:0198506732]
subset: gosubset_prok
synonym: "globoside metabolism" EXACT []
is_a: GO:0006687 ! glycosphingolipid metabolic process

[Term]
id: GO:0001576
name: globoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a ceramide with a core structure of GalNAc-beta-(1->3)-Gal-alpha-(1->4)-Glc(I)." [ISBN:0198506732]
subset: gosubset_prok
synonym: "globoside anabolism" EXACT []
synonym: "globoside biosynthesis" EXACT []
synonym: "globoside formation" EXACT []
synonym: "globoside synthesis" EXACT []
is_a: GO:0001575 ! globoside metabolic process
is_a: GO:0006688 ! glycosphingolipid biosynthetic process

[Term]
id: GO:0001577
name: obsolete galectin
namespace: molecular_function
def: "OBSOLETE. A lectin that exhibits calcium independent binding of beta-galactoside sugars." [PMID:9786891]
comment: This term was made obsolete because it refers to a class of gene products.
synonym: "galectin" EXACT []
synonym: "S-type lectin" EXACT []
is_obsolete: true
consider: GO:0007157
consider: GO:0016936

[Term]
id: GO:0001578
name: microtubule bundle formation
namespace: biological_process
def: "A process that results in a parallel arrangement of microtubules." [GOC:dph]
synonym: "microtubule bundling" EXACT []
is_a: GO:0000226 ! microtubule cytoskeleton organization

[Term]
id: GO:0001579
name: medium-chain fatty acid transport
namespace: biological_process
def: "The directed movement of medium-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A medium-chain fatty acid is a fatty acid with a chain length of between C6 and C12." [CHEBI:59554, GOC:ai]
is_a: GO:0015908 ! fatty acid transport

[Term]
id: GO:0001580
name: detection of chemical stimulus involved in sensory perception of bitter taste
namespace: biological_process
def: "The series of events required for a bitter taste stimulus to be received and converted to a molecular signal." [GOC:go_curators]
synonym: "bitter taste detection" EXACT []
synonym: "perception of bitter taste, detection of chemical stimulus" EXACT []
synonym: "perception of bitter taste, sensory transduction of chemical stimulus" EXACT []
synonym: "sensory detection of bitter taste" EXACT []
synonym: "sensory detection of chemical stimulus during perception of bitter taste" EXACT []
synonym: "sensory transduction of bitter taste" EXACT []
synonym: "sensory transduction of chemical stimulus during perception of bitter taste" EXACT []
is_a: GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste
intersection_of: GO:0009593 ! detection of chemical stimulus
intersection_of: part_of GO:0050913 ! sensory perception of bitter taste
relationship: part_of GO:0050913 ! sensory perception of bitter taste

[Term]
id: GO:0001581
name: detection of chemical stimulus involved in sensory perception of sour taste
namespace: biological_process
def: "The series of events required for a sour taste stimulus to be received and converted to a molecular signal." [GOC:go_curators]
synonym: "perception of sour taste, detection of chemical stimulus" EXACT []
synonym: "perception of sour taste, sensory transduction of chemical stimulus" EXACT []
synonym: "sensory detection of chemical stimulus during perception of sour taste" EXACT []
synonym: "sensory detection of sour taste" EXACT []
synonym: "sensory transduction of chemical stimulus during perception of sour taste" EXACT []
synonym: "sensory transduction of sour taste" EXACT []
synonym: "sour taste detection" EXACT []
is_a: GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste
intersection_of: GO:0009593 ! detection of chemical stimulus
intersection_of: part_of GO:0050915 ! sensory perception of sour taste
relationship: part_of GO:0050915 ! sensory perception of sour taste

[Term]
id: GO:0001582
name: detection of chemical stimulus involved in sensory perception of sweet taste
namespace: biological_process
def: "The series of events required for a sweet taste stimulus to be received and converted to a molecular signal." [GOC:go_curators]
synonym: "perception of sweet taste, detection of chemical stimulus" EXACT []
synonym: "perception of sweet taste, sensory transduction of chemical stimulus" EXACT []
synonym: "sensory detection of chemical stimulus during perception of sweet taste" EXACT []
synonym: "sensory detection of sweet taste" EXACT []
synonym: "sensory transduction of chemical stimulus during perception of sweet taste" EXACT []
synonym: "sensory transduction of sweet taste" EXACT []
synonym: "sweet taste detection" EXACT []
is_a: GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste
intersection_of: GO:0009593 ! detection of chemical stimulus
intersection_of: part_of GO:0050916 ! sensory perception of sweet taste
relationship: part_of GO:0050916 ! sensory perception of sweet taste

[Term]
id: GO:0001583
name: detection of chemical stimulus involved in sensory perception of salty taste
namespace: biological_process
def: "The series of events required for a salty taste stimulus to be received and converted to a molecular signal." [GOC:go_curators]
synonym: "perception of salty taste, detection of chemical stimulus" EXACT []
synonym: "perception of salty taste, sensory transduction of chemical stimulus" EXACT []
synonym: "salty taste detection" EXACT []
synonym: "sensory detection of chemical stimulus during perception of salty taste" EXACT []
synonym: "sensory detection of salty taste" EXACT []
synonym: "sensory transduction of chemical stimulus during perception of salty taste" EXACT []
synonym: "sensory transduction of salty taste" EXACT []
is_a: GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste
intersection_of: GO:0009593 ! detection of chemical stimulus
intersection_of: part_of GO:0050914 ! sensory perception of salty taste
relationship: part_of GO:0050914 ! sensory perception of salty taste

[Term]
id: GO:0001584
name: obsolete rhodopsin-like receptor activity
namespace: molecular_function
alt_id: GO:0001620
def: "OBSOLETE. A G-protein coupled receptor that is structurally/functionally related to the rhodopsin receptor." [GOC:dph, GOC:mah, GOC:tb, IUPHAR_GPCR:1505]
comment: This term was made obsolete because it represents a gene product and is named based on protein features.
subset: gosubset_prok
synonym: "Class A G protein coupled receptor" EXACT []
synonym: "Class A G-protein coupled receptor" EXACT []
synonym: "Class A GPCR" EXACT []
synonym: "class A orphan receptor activity" EXACT []
synonym: "rhodopsin-like receptor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0001586
name: Gi/o-coupled serotonin receptor activity
namespace: molecular_function
def: "Combining with serotonin and transmitting the signal across the membrane by activation of the Gi/o subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gi/o subunit subsequently inhibits adenylate cyclase and results in a decrease in cyclic AMP (cAMP) levels." [GOC:mah, PMID:18571247]
synonym: "5-HT1 receptor activity" EXACT [GOC:bf]
synonym: "serotonin receptor activity, coupled via Gi/o" EXACT [GOC:bf]
is_a: GO:0004993 ! G-protein coupled serotonin receptor activity

[Term]
id: GO:0001587
name: Gq/11-coupled serotonin receptor activity
namespace: molecular_function
def: "Combining with serotonin and transmitting the signal across the membrane by activation of the Gq/11 subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gq/11 subunit subsequently activates phospholipase C and results in an increase in inositol triphosphate (IP3) levels." [GOC:bf, GOC:mah, PMID:18571247, PMID:18703043]
synonym: "5-HT2 receptor activity" BROAD [GOC:bf]
synonym: "serotonin receptor activity, coupled via Gq/11" EXACT [GOC:bf]
is_a: GO:0004993 ! G-protein coupled serotonin receptor activity

[Term]
id: GO:0001588
name: dopamine neurotransmitter receptor activity, coupled via Gs
namespace: molecular_function
alt_id: GO:0001589
alt_id: GO:0001590
def: "Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gs to initiate a change in cell activity." [GOC:mah, ISBN:0953351033, IUPHAR_RECEPTOR:2252, IUPHAR_RECEPTOR:2260]
synonym: "dopamine D1 receptor activity" NARROW [GOC:bf]
synonym: "dopamine D5 receptor activity" NARROW [GOC:bf]
is_a: GO:0004952 ! dopamine neurotransmitter receptor activity

[Term]
id: GO:0001591
name: dopamine neurotransmitter receptor activity, coupled via Gi/Go
namespace: molecular_function
alt_id: GO:0001592
alt_id: GO:0001593
alt_id: GO:0001670
def: "Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gi/Go to initiate a change in cell activity." [GOC:mah, ISBN:0953351033, IUPHAR_RECEPTOR:2254, IUPHAR_RECEPTOR:2256, IUPHAR_RECEPTOR:2258]
synonym: "dopamine D2 receptor activity" NARROW [GOC:bf]
synonym: "dopamine D3 receptor activity" NARROW [GOC:bf]
synonym: "dopamine D4 receptor activity" NARROW [GOC:bf]
is_a: GO:0004952 ! dopamine neurotransmitter receptor activity

[Term]
id: GO:0001594
name: trace-amine receptor activity
namespace: molecular_function
def: "Combining with a trace amine to initiate a change in cell activity. Trace amines are biogenic amines that are synthesized from aromatic amino acids and are substrates for monoamine oxidase, and are therefore detectable only at trace levels in mammals." [GOC:mah, PMID:19325074]
is_a: GO:0008227 ! G-protein coupled amine receptor activity

[Term]
id: GO:0001595
name: angiotensin receptor activity
namespace: molecular_function
def: "Combining with angiotensin to initiate a change in cell activity." [GOC:ai]
is_a: GO:0008528 ! G-protein coupled peptide receptor activity
relationship: part_of GO:0038166 ! angiotensin-activated signaling pathway

[Term]
id: GO:0001596
name: angiotensin type I receptor activity
namespace: molecular_function
def: "An angiotensin receptor activity that acts via Gq-mediated activation of phospholipase C followed by phosphoinositide hydrolysis and Ca2+ signaling, and may act via additional signaling mechanisms." [GOC:mah, PMID:10977869]
synonym: "PLC-activating angiotensin receptor activity" EXACT [GOC:bf]
is_a: GO:0001595 ! angiotensin receptor activity
relationship: part_of GO:0086097 ! phospholipase C-activating angiotensin-activated signaling pathway

[Term]
id: GO:0001597
name: obsolete apelin-like receptor
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because the function it represents does not exist.
synonym: "apelin-like receptor" EXACT []
synonym: "APJ-like receptor" EXACT []
is_obsolete: true
consider: GO:0031704

[Term]
id: GO:0001598
name: obsolete chemokine receptor-like receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features.
synonym: "chemokine receptor-like receptor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0001601
name: peptide YY receptor activity
namespace: molecular_function
def: "Combining with gut peptide YY to initiate a change in cell activity." [PMID:9315606]
is_a: GO:0004983 ! neuropeptide Y receptor activity

[Term]
id: GO:0001602
name: pancreatic polypeptide receptor activity
namespace: molecular_function
def: "Combining with pancreatic polypeptide PP to initiate a change in cell activity." [PMID:9315606]
is_a: GO:0004983 ! neuropeptide Y receptor activity

[Term]
id: GO:0001603
name: obsolete vasopressin-like receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:curators]
synonym: "vasopressin-like receptor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0001604
name: urotensin II receptor activity
namespace: molecular_function
def: "Combining with urotensin II to initiate a change in cell activity." [GOC:mah, PMID:15102493]
is_a: GO:0008528 ! G-protein coupled peptide receptor activity

[Term]
id: GO:0001605
name: adrenomedullin receptor activity
namespace: molecular_function
def: "Combining with adrenomedullin to initiate a change in cell activity." [GOC:ai]
synonym: "G10D receptor" NARROW []
is_a: GO:0097642 ! calcitonin family receptor activity

[Term]
id: GO:0001606
name: obsolete GPR37/endothelin B-like receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features.
synonym: "GPR37/endothelin B-like receptor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0001607
name: neuromedin U receptor activity
namespace: molecular_function
def: "Combining with neuromedin U to initiate a change in cell activity." [GOC:ai]
synonym: "NMUR activity" EXACT []
is_a: GO:0008188 ! neuropeptide receptor activity
relationship: has_part GO:0042924 ! neuromedin U binding

[Term]
id: GO:0001608
name: G-protein coupled nucleotide receptor activity
namespace: molecular_function
def: "Combining with a nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph, IUPHAR_GPCR:1294]
synonym: "G protein coupled nucleotide receptor activity" EXACT []
synonym: "G-protein-coupled nucleotide receptor activity" EXACT []
synonym: "nucleotide receptor activity, G protein coupled" EXACT []
synonym: "nucleotide receptor activity, G-protein coupled" EXACT [GOC:bf]
is_a: GO:0004930 ! G-protein coupled receptor activity

[Term]
id: GO:0001609
name: G-protein coupled adenosine receptor activity
namespace: molecular_function
alt_id: GO:0001610
alt_id: GO:0001611
alt_id: GO:0001612
alt_id: GO:0001613
alt_id: GO:0008501
def: "Combining with adenosine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:mah, PMID:9755289]
synonym: "A1 adenosine receptor activity, G protein coupled" NARROW []
synonym: "A1 adenosine receptor activity, G-protein coupled" NARROW []
synonym: "A2A adenosine receptor activity, G protein coupled" NARROW []
synonym: "A2A adenosine receptor activity, G-protein coupled" NARROW []
synonym: "A2B adenosine receptor activity, G protein coupled" NARROW []
synonym: "A2B adenosine receptor activity, G-protein coupled" NARROW []
synonym: "A3 adenosine receptor activity, G protein coupled" NARROW []
synonym: "A3 adenosine receptor activity, G-protein coupled" NARROW []
synonym: "adenosine nucleotide receptor" BROAD []
synonym: "adenosine receptor activity, G protein coupled" EXACT []
synonym: "adenosine receptor activity, G-protein coupled" EXACT [GOC:bf]
synonym: "G protein coupled A1 adenosine receptor activity" NARROW []
synonym: "G protein coupled A2A adenosine receptor activity" NARROW []
synonym: "G protein coupled A2B adenosine receptor activity" NARROW []
synonym: "G protein coupled A3 adenosine receptor activity" NARROW []
synonym: "G protein coupled adenosine receptor activity" EXACT []
synonym: "G-protein-coupled A1 adenosine receptor activity" NARROW []
synonym: "G-protein-coupled A2A adenosine receptor activity" NARROW []
synonym: "G-protein-coupled A2B adenosine receptor activity" NARROW []
synonym: "G-protein-coupled A3 adenosine receptor activity" NARROW []
synonym: "G-protein-coupled adenosine receptor activity" EXACT []
synonym: "P1 receptor" EXACT [PMID:9755289]
xref: Reactome:REACT_105855 "TRKA activation by adenosine A2a receptor, Bos taurus"
xref: Reactome:REACT_110350 "TRKA activation by adenosine A2a receptor, Canis familiaris"
xref: Reactome:REACT_11079 "TrkA activation by adenosine A2a receptor, Rattus norvegicus"
xref: Reactome:REACT_29695 "TRKA activation by adenosine A2a receptor, Sus scrofa"
xref: Reactome:REACT_36513 "TRKA activation by adenosine A2a receptor, Gallus gallus"
xref: Reactome:REACT_79823 "TRKA activation by adenosine A2a receptor, Danio rerio"
xref: Reactome:REACT_89799 "TRKA activation by adenosine A2a receptor, Taeniopygia guttata"
xref: Reactome:REACT_97530 "TRKA activation by adenosine A2a receptor, Xenopus tropicalis"
xref: Reactome:REACT_9980 "TRKA activation by adenosine A2a receptor, Homo sapiens"
xref: Reactome:REACT_99869 "TRKA activation by adenosine A2a receptor, Mus musculus"
is_a: GO:0004930 ! G-protein coupled receptor activity
is_a: GO:0035586 ! purinergic receptor activity
relationship: part_of GO:0001973 ! adenosine receptor signaling pathway

[Term]
id: GO:0001614
name: purinergic nucleotide receptor activity
namespace: molecular_function
def: "Combining with a purine nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling]
synonym: "P2 receptor" RELATED [PMID:9755289]
is_a: GO:0016502 ! nucleotide receptor activity
is_a: GO:0035586 ! purinergic receptor activity
relationship: has_part GO:0017076 ! purine nucleotide binding
relationship: part_of GO:0035590 ! purinergic nucleotide receptor signaling pathway

[Term]
id: GO:0001615
name: obsolete thyrotropin releasing hormone and secretagogue-like receptors activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features.
synonym: "thyrotropin releasing hormone and secretagogue-like receptors activity" EXACT []
is_obsolete: true

[Term]
id: GO:0001616
name: growth hormone secretagogue receptor activity
namespace: molecular_function
def: "Combining with ghrelin to initiate a change in cell activity." [GOC:mah, PMID:17983853]
synonym: "ghrelin receptor activity" EXACT [GOC:mah, PMID:17983853]
is_a: GO:0004930 ! G-protein coupled receptor activity

[Term]
id: GO:0001617
name: obsolete growth hormone secretagogue-like receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features.
synonym: "growth hormone secretagogue-like receptor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0001618
name: virus receptor activity
namespace: molecular_function
def: "Combining with a virus component and mediating entry of the virus into the cell." [GOC:bf, GOC:dph, PMID:7621403, UniProtKB-KW:KW-1183]
subset: goslim_chembl
synonym: "viral receptor activity" EXACT []
is_a: GO:0004872 ! receptor activity
relationship: part_of GO:0046718 ! viral entry into host cell

[Term]
id: GO:0001619
name: obsolete lysosphingolipid and lysophosphatidic acid receptor activity
namespace: molecular_function
def: "Combining with lysosphingolipid or lysophosphatidic acid to initiate a change in cell activity." [GOC:dph]
synonym: "lysosphingolipid and lysophosphatidic acid receptor activity" EXACT []
is_obsolete: true
consider: GO:0038036
consider: GO:0070915

[Term]
id: GO:0001621
name: ADP receptor activity
namespace: molecular_function
def: "Combining with ADP and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling, PMID:11196645]
synonym: "K101 receptor" NARROW []
synonym: "platelet ADP receptor activity" NARROW [GOC:mah]
is_a: GO:0045028 ! G-protein coupled purinergic nucleotide receptor activity
relationship: has_part GO:0043531 ! ADP binding

[Term]
id: GO:0001626
name: nociceptin receptor activity
namespace: molecular_function
def: "Combining with the peptide nociceptin, and transmitting the signal across the membrane by activating an associated G-protein." [GOC:bf, GOC:mah, PMID:18670432]
synonym: "nociceptin/orphanin-FQ receptor activity" EXACT [GOC:bf]
synonym: "OFQ receptor activity" EXACT [PR:000012940]
synonym: "ORPH receptor" EXACT []
synonym: "orphanin-FQ receptor activity" EXACT [GOC:bf]
synonym: "X-opioid receptor activity" RELATED [GOC:bf]
is_a: GO:0004985 ! opioid receptor activity

[Term]
id: GO:0001627
name: obsolete leucine-rich G-protein receptor-like receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features.
synonym: "leucine-rich G protein receptor-like receptor activity" EXACT []
synonym: "leucine-rich G-protein receptor-like receptor activity" EXACT []
synonym: "LGR-like receptor" EXACT []
is_obsolete: true

[Term]
id: GO:0001628
name: obsolete gastropyloric receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because the gastropyloric receptor is a type of neuron.
synonym: "gastropyloric receptor activity" EXACT []
synonym: "GPR receptor" EXACT []
is_obsolete: true

[Term]
id: GO:0001629
name: obsolete G-protein receptor 45-like receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features.
synonym: "G protein receptor 45-like receptor activity" EXACT []
synonym: "G-protein receptor 45-like receptor activity" EXACT []
synonym: "GPR45-like receptor" EXACT []
is_obsolete: true

[Term]
id: GO:0001630
name: obsolete GP40-like receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features.
synonym: "GP40-like receptor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0001631
name: cysteinyl leukotriene receptor activity
namespace: molecular_function
def: "Combining with a cysteinyl leukotriene to initiate a change in cell activity. Cysteinyl leukotrienes are leukotrienes that contain a peptide group based on cysteine." [GOC:ai, ISBN:0198506732]
synonym: "CysLT receptor" EXACT []
is_a: GO:0004974 ! leukotriene receptor activity

[Term]
id: GO:0001632
name: leukotriene B4 receptor activity
namespace: molecular_function
def: "Combining with leukotriene B4, LTB4, to initiate a change in cell activity. Leukotriene B4 is also known as (6Z, 8E, 10E, 14Z)-(5S, 12R)-5,12-dihydroxyicosa-6,8,10,14-tetraen-1-oate." [GOC:ai, ISBN:0198506732]
synonym: "BLT receptor" NARROW []
is_a: GO:0004974 ! leukotriene receptor activity

[Term]
id: GO:0001633
name: obsolete secretin-like receptor activity
namespace: molecular_function
alt_id: GO:0001638
def: "OBSOLETE. A G-protein coupled receptor that is structurally/functionally related to the secretin receptor." [GOC:mah, IUPHAR_GPCR:1506]
comment: This term was made obsolete because it represents a gene product and is named based on protein features.
synonym: "class B G protein coupled receptor" EXACT []
synonym: "class B G-protein coupled receptor" EXACT []
synonym: "class B GPCR" EXACT []
synonym: "class B orphan receptor activity" EXACT []
synonym: "secretin-like receptor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0001634
name: pituitary adenylate cyclase-activating polypeptide receptor activity
namespace: molecular_function
alt_id: GO:0016522
def: "A G-protein coupled receptor that interacts with pituitary adenylate cyclase-activating polypeptide." [GOC:dph, GOC:tb]
synonym: "PACAP receptor" EXACT []
synonym: "pituitary adenylate cyclase activating polypeptide receptor" EXACT []
synonym: "pituitary adenylate cyclase activating protein receptor activity" EXACT [GOC:dph, GOC:tb]
synonym: "pituitary adenylate cyclase-activating peptide receptor activity" RELATED []
synonym: "pituitary adenylate cyclase-activating polypeptide receptor activity" RELATED []
synonym: "pituitary adenylyl cyclase activating protein receptor activity" EXACT []
xref: Reactome:REACT_10128 "TRKA activation by PACAP type 1 receptor, Homo sapiens"
xref: Reactome:REACT_101685 "TRKA activation by PACAP type 1 receptor, Canis familiaris"
xref: Reactome:REACT_109490 "TRKA activation by PACAP type 1 receptor, Taeniopygia guttata"
xref: Reactome:REACT_11114 "TrkA activation by PACAP type 1 receptor, Rattus norvegicus"
xref: Reactome:REACT_34105 "TRKA activation by PACAP type 1 receptor, Mus musculus"
xref: Reactome:REACT_86120 "TRKA activation by PACAP type 1 receptor, Xenopus tropicalis"
xref: Reactome:REACT_87714 "TRKA activation by PACAP type 1 receptor, Bos taurus"
xref: Reactome:REACT_91558 "TRKA activation by PACAP type 1 receptor, Danio rerio"
xref: Reactome:REACT_92997 "TRKA activation by PACAP type 1 receptor, Gallus gallus"
xref: Reactome:REACT_96326 "TRKA activation by PACAP type 1 receptor, Sus scrofa"
is_a: GO:0004930 ! G-protein coupled receptor activity

[Term]
id: GO:0001635
name: calcitonin gene-related peptide receptor activity
namespace: molecular_function
def: "Combining with a calcitonin gene-related polypeptide (CGRP) to initiate a change in cell activity." [GOC:mah, PMID:12037140]
synonym: "calcitonin gene-related polypeptide receptor activity" EXACT []
synonym: "CGRP receptor" EXACT []
xref: Wikipedia:CALCRL
is_a: GO:0097642 ! calcitonin family receptor activity

[Term]
id: GO:0001636
name: obsolete corticotrophin-releasing factor gastric inhibitory peptide-like receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features.
synonym: "corticotrophin-releasing factor gastric inhibitory peptide-like receptor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0001637
name: G-protein coupled chemoattractant receptor activity
namespace: molecular_function
def: "Combining with a chemoattractant and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:mah]
synonym: "G protein chemoattractant receptor activity" EXACT []
synonym: "G-protein chemoattractant receptor activity" EXACT [GOC:bf]
is_a: GO:0008528 ! G-protein coupled peptide receptor activity

[Term]
id: GO:0001639
name: PLC activating G-protein coupled glutamate receptor activity
namespace: molecular_function
def: "A G-protein coupled receptor that binds glutamate and is linked to the inositol 1,4,5-trisphosphate/calcium signaling system." [PMID:9016303]
synonym: "Group I metabotropic glutamate receptor" RELATED []
synonym: "group I metabotropic glutamate receptor activity" RELATED []
synonym: "phospholipase C activating metabotropic glutamate receptor activity" EXACT []
synonym: "PLC activating metabotropic glutamate receptor activity" EXACT [GOC:bf]
is_a: GO:0008066 ! glutamate receptor activity
relationship: part_of GO:0007206 ! phospholipase C-activating G-protein coupled glutamate receptor signaling pathway

[Term]
id: GO:0001640
name: adenylate cyclase inhibiting G-protein coupled glutamate receptor activity
namespace: molecular_function
def: "Combining with glutamate and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex to inhibit downstream adenylate cyclase activity." [GOC:bf, GOC:dph]
synonym: "adenylate cyclase inhibiting metabotropic glutamate receptor activity" RELATED [GOC:bf]
synonym: "adenylyl cyclase inhibiting metabotropic glutamate receptor activity" EXACT []
is_a: GO:0004930 ! G-protein coupled receptor activity
is_a: GO:0008066 ! glutamate receptor activity
relationship: part_of GO:0007196 ! adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway

[Term]
id: GO:0001641
name: group II metabotropic glutamate receptor activity
namespace: molecular_function
def: "A G-protein coupled receptor that is activated by trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) and inhibits adenylate cyclase activity." [GOC:dph]
is_a: GO:0001640 ! adenylate cyclase inhibiting G-protein coupled glutamate receptor activity

[Term]
id: GO:0001642
name: group III metabotropic glutamate receptor activity
namespace: molecular_function
def: "A G-protein coupled receptor that is activated by L-AP-4 and inhibits adenylate cyclase activity." [PMID:9016303]
is_a: GO:0001640 ! adenylate cyclase inhibiting G-protein coupled glutamate receptor activity

[Term]
id: GO:0001646
name: cAMP receptor activity
namespace: molecular_function
alt_id: GO:0001644
def: "Combining with cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:pg]
synonym: "3',5' cAMP receptor activity" EXACT []
synonym: "3',5'-cAMP receptor activity" EXACT []
synonym: "adenosine 3',5'-cyclophosphate receptor activity" EXACT []
synonym: "class E G protein coupled receptor" BROAD []
synonym: "class E G-protein coupled receptor" BROAD []
synonym: "class E GPCR" BROAD []
synonym: "cyclic AMP receptor activity" EXACT []
is_a: GO:0001614 ! purinergic nucleotide receptor activity
relationship: has_part GO:0030552 ! cAMP binding

[Term]
id: GO:0001647
name: G-protein coupled cytokinin receptor activity
namespace: molecular_function
def: "Combining with cytokinin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph]
synonym: "cytokinin receptor activity, G-protein coupled" EXACT [GOC:bf]
synonym: "G protein coupled cytokinin receptor activity" EXACT []
synonym: "G-protein-coupled cytokinin receptor activity" EXACT []
is_a: GO:0004930 ! G-protein coupled receptor activity
is_a: GO:0009884 ! cytokinin receptor activity

[Term]
id: GO:0001648
name: proteinase activated receptor activity
namespace: molecular_function
def: "A G-protein coupled peptide receptor activity that is initiated by cleavage of the N terminus of the receptor by a serine protease, resulting in the generation of a new tethered ligand that interacts with the receptor." [GOC:mah, PMID:11356985]
is_a: GO:0008528 ! G-protein coupled peptide receptor activity

[Term]
id: GO:0001649
name: osteoblast differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone." [CL:0000062, GO_REF:0000034, GOC:jid]
synonym: "osteoblast cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0001503 ! ossification

[Term]
id: GO:0001650
name: fibrillar center
namespace: cellular_component
def: "A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures." [PMID:10754561]
synonym: "fibrillar centre" EXACT []
is_a: GO:0044452 ! nucleolar part

[Term]
id: GO:0001651
name: dense fibrillar component
namespace: cellular_component
def: "A structure found in the nucleolus, which contains newly synthesized preribosomal RNA (pre-rRNA) and a collection of proteins." [PMID:10754561]
synonym: "pars fibrosa" BROAD [NIF_Subcellular:sao1841764412]
xref: NIF_Subcellular:sao1841764412
is_a: GO:0044452 ! nucleolar part

[Term]
id: GO:0001652
name: granular component
namespace: cellular_component
def: "A structure found in the nucleolus, which contains nearly completed preribosomal particles destined for the cytoplasm." [PMID:10754561]
synonym: "pars granulosa" BROAD [NIF_Subcellular:sao1217793903]
xref: NIF_Subcellular:sao1217793903
is_a: GO:0044452 ! nucleolar part

[Term]
id: GO:0001653
name: peptide receptor activity
namespace: molecular_function
def: "Combining with an extracellular or intracellular peptide to initiate a change in cell activity." [GOC:jl]
synonym: "endogenous peptide receptor activity" NARROW []
synonym: "exogenous peptide receptor activity" NARROW []
is_a: GO:0038023 ! signaling receptor activity
relationship: has_part GO:0042277 ! peptide binding

[Term]
id: GO:0001654
name: eye development
namespace: biological_process
alt_id: GO:0042460
def: "The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight." [GOC:jid, GOC:jl]
xref: Wikipedia:Eye_development
is_a: GO:0007423 ! sensory organ development

[Term]
id: GO:0001655
name: urogenital system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure." [GOC:go_curators]
is_a: GO:0048731 ! system development

[Term]
id: GO:0001656
name: metanephros development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:bf, ISBN:0192800752]
is_a: GO:0001822 ! kidney development

[Term]
id: GO:0001657
name: ureteric bud development
namespace: biological_process
def: "The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure." [GOC:go_curators]
is_a: GO:0072164 ! mesonephric tubule development
relationship: part_of GO:0072001 ! renal system development

[Term]
id: GO:0001658
name: branching involved in ureteric bud morphogenesis
namespace: biological_process
def: "The process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules." [GOC:dph, PMID:16916378]
synonym: "ureteric bud branching" EXACT [GOC:dph]
is_a: GO:0048754 ! branching morphogenesis of an epithelial tube
intersection_of: GO:0001763 ! morphogenesis of a branching structure
intersection_of: part_of GO:0060675 ! ureteric bud morphogenesis
relationship: part_of GO:0060675 ! ureteric bud morphogenesis

[Term]
id: GO:0001659
name: temperature homeostasis
namespace: biological_process
def: "A homeostatic process in which an organism modulates its internal body temperature." [GOC:jl]
synonym: "thermoregulation" EXACT [GOC:dph, GOC:tb]
xref: Wikipedia:Thermoregulation
is_a: GO:0048871 ! multicellular organismal homeostasis

[Term]
id: GO:0001660
name: fever generation
namespace: biological_process
def: "The heat generation process that results in a rise in body temperature above the normal, often as a response to infection." [GOC:dph, GOC:jl]
synonym: "pyrexia" BROAD []
xref: Wikipedia:Fever
is_a: GO:0006953 ! acute-phase response
is_a: GO:0031649 ! heat generation

[Term]
id: GO:0001661
name: conditioned taste aversion
namespace: biological_process
def: "A conditioned aversion to a specific chemical compound as a result of that compound being coupled with a noxious stimulus." [GOC:dph, PMID:9920659]
xref: Wikipedia:Conditioned_taste_aversion
xref: Wikipedia:Taste_aversion
is_a: GO:0007631 ! feeding behavior
is_a: GO:0008306 ! associative learning

[Term]
id: GO:0001662
name: behavioral fear response
namespace: biological_process
def: "An acute behavioral change resulting from a perceived external threat." [GOC:dph, PMID:9920659]
synonym: "behavioural fear response" EXACT []
is_a: GO:0002209 ! behavioral defense response
is_a: GO:0042596 ! fear response
is_a: GO:0044708 ! single-organism behavior

[Term]
id: GO:0001664
name: G-protein coupled receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a G-protein coupled receptor." [GOC:ceb, GOC:dph]
synonym: "G protein coupled receptor binding" EXACT []
synonym: "G protein coupled receptor ligand" NARROW []
synonym: "G-protein-coupled receptor binding" EXACT [GOC:bf]
synonym: "G-protein-coupled receptor ligand" NARROW []
xref: Reactome:REACT_21309 "Activation of GRIK3 homomer, Homo sapiens"
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0001665
name: alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein." [EC:2.4.99.3]
synonym: "CMP-N-acetylneuraminate:glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein alpha-2,6-N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.3]
synonym: "GalNAc alpha-2,6-sialyltransferase I activity" EXACT [EC:2.4.99.3]
xref: EC:2.4.99.3
xref: MetaCyc:2.4.99.3-RXN
is_a: GO:0008373 ! sialyltransferase activity

[Term]
id: GO:0001666
name: response to hypoxia
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd]
comment: Note that this term should not be confused with 'response to anoxia ; GO:0034059'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%.
synonym: "response to hypoxic stress" EXACT []
synonym: "response to intermittent hypoxia" NARROW []
synonym: "response to lowered oxygen tension" EXACT []
synonym: "response to sustained hypoxia" NARROW []
is_a: GO:0006950 ! response to stress
is_a: GO:0036293 ! response to decreased oxygen levels

[Term]
id: GO:0001667
name: ameboidal-type cell migration
namespace: biological_process
def: "Cell migration that is accomplished by extension and retraction of a pseudopodium." [GOC:dph]
comment: Note that this term refer to a mode of migration rather than to any particular cell type.
synonym: "ameboid cell migration" EXACT []
synonym: "amoeboid cell migration" EXACT []
synonym: "amoeboidal cell migration" EXACT []
is_a: GO:0016477 ! cell migration

[Term]
id: GO:0001669
name: acrosomal vesicle
namespace: cellular_component
def: "A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome." [ISBN:0124325653, ISBN:0198506732]
synonym: "acrosomal granule" EXACT [GOC:sart]
synonym: "acrosome" EXACT [GOC:dph]
xref: Wikipedia:Acrosome
is_a: GO:0030141 ! secretory granule
is_a: GO:0097223 ! sperm part

[Term]
id: GO:0001671
name: ATPase activator activity
namespace: molecular_function
def: "Binds to and increases the ATP hydrolysis activity of an ATPase." [GOC:ajp]
synonym: "ATPase stimulator activity" EXACT []
is_a: GO:0008047 ! enzyme activator activity
is_a: GO:0060590 ! ATPase regulator activity
relationship: part_of GO:0032781 ! positive regulation of ATPase activity
relationship: positively_regulates GO:0016887 ! ATPase activity

[Term]
id: GO:0001672
name: regulation of chromatin assembly or disassembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chromatin assembly or disassembly." [GOC:go_curators]
synonym: "regulation of chromatin assembly/disassembly" EXACT []
is_a: GO:1902275 ! regulation of chromatin organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006333 ! chromatin assembly or disassembly
relationship: regulates GO:0006333 ! chromatin assembly or disassembly

[Term]
id: GO:0001673
name: male germ cell nucleus
namespace: cellular_component
alt_id: GO:0043081
def: "The nucleus of a male germ cell, a reproductive cell in males." [CL:0000015, GOC:hjd, GOC:mtg_sensu]
synonym: "male germ-cell nucleus" EXACT []
is_a: GO:0043073 ! germ cell nucleus

[Term]
id: GO:0001674
name: female germ cell nucleus
namespace: cellular_component
alt_id: GO:0043080
def: "The nucleus of the female germ cell, a reproductive cell in females." [CL:0000021, GOC:hjd]
synonym: "female germ-cell nucleus" EXACT []
is_a: GO:0043073 ! germ cell nucleus

[Term]
id: GO:0001675
name: acrosome assembly
namespace: biological_process
def: "The formation of the acrosome from the spermatid Golgi." [GOC:dph, GOC:hjd, GOC:tb]
synonym: "acrosome formation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0033363 ! secretory granule organization
is_a: GO:0070925 ! organelle assembly
is_a: GO:1902589 ! single-organism organelle organization
relationship: part_of GO:0007286 ! spermatid development

[Term]
id: GO:0001676
name: long-chain fatty acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving long-chain fatty acids, A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [CHEBI:15904, GOC:ajp]
subset: gosubset_prok
synonym: "long-chain fatty acid metabolism" EXACT []
is_a: GO:0006631 ! fatty acid metabolic process

[Term]
id: GO:0001677
name: formation of translation initiation ternary complex
namespace: biological_process
def: "Formation of a complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator)." [GOC:hjd]
subset: gosubset_prok
synonym: "translation initiation ternary complex assembly" EXACT []
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0006413 ! translational initiation

[Term]
id: GO:0001678
name: cellular glucose homeostasis
namespace: biological_process
def: "A cellular homeostatic process involved in the maintenance of an internal steady state of glucose within a cell or between a cell and its external environment." [GOC:dph, GOC:go_curators, GOC:tb]
subset: gosubset_prok
synonym: "cell glucose homeostasis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0042593 ! glucose homeostasis
is_a: GO:0055082 ! cellular chemical homeostasis

[Term]
id: GO:0001680
name: tRNA 3'-terminal CCA addition
namespace: biological_process
def: "Post-transcriptional addition of the terminal 3' CCA sequence to a tRNA which does not encode this sequence within the primary transcript. CCA addition proceeds by the sequential addition of CTP, CTP, and then ATP to the 3' end of the tRNA, yielding a diphosphate with each nucleotide addition." [EC:2.7.7.72, GOC:go_curators]
subset: gosubset_prok
synonym: "-C-C-A pyrophosphorylase activity" RELATED [EC:2.7.7.72]
synonym: "ATP(CTP)-tRNA nucleotidyltransferase activity" BROAD [EC:2.7.7.72]
synonym: "ATP(CTP):tRNA nucleotidyltransferase activity" BROAD [EC:2.7.7.72]
synonym: "CCA tRNA nucleotidyltransferase activity" BROAD [EC:2.7.7.72]
synonym: "CCA-adding enzyme activity" EXACT [EC:2.7.7.72]
synonym: "CCA-adding enzyme, tRNA adenylyltransferase, tRNA cytidylyltransferase, tRNA CCA-pyrophosphorylase activity" EXACT [EC:2.7.7.72]
synonym: "CTP(ATP):tRNA nucleotidyltransferase activity" BROAD [EC:2.7.7.72]
synonym: "CTP:tRNA cytidylyltransferase activity" NARROW [EC:2.7.7.72]
synonym: "ribonucleic cytidylic cytidylic adenylic pyrophosphorylase activity" EXACT [EC:2.7.7.72]
synonym: "ribonucleic cytidylyltransferase activity" NARROW [EC:2.7.7.72]
synonym: "transfer ribonucleate adenyltransferase activity" NARROW [EC:2.7.7.72]
synonym: "transfer ribonucleate adenylyltransferase activity" NARROW [EC:2.7.7.72]
synonym: "transfer ribonucleate cytidylyltransferase activity" NARROW [EC:2.7.7.72]
synonym: "transfer ribonucleate nucleotidyltransferase activity" BROAD [EC:2.7.7.72]
synonym: "transfer ribonucleic acid nucleotidyl transferase activity" BROAD [EC:2.7.7.72]
synonym: "transfer ribonucleic adenylyl (cytidylyl) transferase activity" RELATED [EC:2.7.7.72]
synonym: "transfer ribonucleic-terminal trinucleotide nucleotidyltransferase activity" BROAD [EC:2.7.7.72]
synonym: "transfer RNA adenylyltransferase activity" NARROW [EC:2.7.7.72]
synonym: "transfer-RNA nucleotidyltransferase activity" BROAD [EC:2.7.7.72]
synonym: "tRNA adenylyl(cytidylyl)transferase activity" BROAD [EC:2.7.7.72]
synonym: "tRNA CCA-diphosphorylase activity" RELATED [EC:2.7.7.72]
synonym: "tRNA cytidylyltransferase activity" NARROW [EC:2.7.7.72]
synonym: "tRNA-nucleotidyltransferase activity" BROAD [EC:2.7.7.72]
xref: EC:2.7.7.72
xref: KEGG:R09382
xref: MetaCyc:TRNA-CYTIDYLYLTRANSFERASE-RXN
is_a: GO:0042780 ! tRNA 3'-end processing
relationship: has_part GO:0052927 ! CTP:tRNA cytidylyltransferase activity
relationship: has_part GO:0052928 ! CTP:3'-cytidine-tRNA cytidylyltransferase activity
relationship: has_part GO:0052929 ! ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity

[Term]
id: GO:0001681
name: sialate O-acetylesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-O-acetylneuraminate (free or glycosidically bound) + H2O = N-acetylneuraminate + acetate." [EC:3.1.1.53, PMID:1991039]
subset: gosubset_prok
synonym: "N-acetylneuraminate acetyltransferase activity" EXACT [EC:3.1.1.53]
synonym: "N-acyl-O-acetylneuraminate O-acetylhydrolase activity" EXACT [EC:3.1.1.53]
synonym: "sialate 9(4)-O-acetylesterase activity" EXACT []
xref: EC:3.1.1.53
xref: MetaCyc:SIALATE-O-ACETYLESTERASE-RXN
is_a: GO:0008126 ! acetylesterase activity

[Term]
id: GO:0001682
name: tRNA 5'-leader removal
namespace: biological_process
def: "Generation of the mature 5'-end of the tRNA, usually via an endonucleolytic cleavage by RNase P." [PMID:11592395]
subset: gosubset_prok
synonym: "tRNA 5' leader removal" EXACT []
is_a: GO:0008033 ! tRNA processing

[Term]
id: GO:0001683
name: obsolete axonemal dynein heavy chain
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "axonemal dynein heavy chain" EXACT []
is_obsolete: true
replaced_by: GO:0005858

[Term]
id: GO:0001684
name: obsolete axonemal dynein intermediate chain
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "axonemal dynein intermediate chain" EXACT []
is_obsolete: true
replaced_by: GO:0005858

[Term]
id: GO:0001685
name: obsolete axonemal dynein intermediate light chain
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "axonemal dynein intermediate light chain" EXACT []
is_obsolete: true
replaced_by: GO:0005858

[Term]
id: GO:0001686
name: obsolete axonemal dynein light chain
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "axonemal dynein light chain" EXACT []
is_obsolete: true
replaced_by: GO:0005858

[Term]
id: GO:0001687
name: obsolete cytoplasmic dynein heavy chain
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "cytoplasmic dynein heavy chain" EXACT []
is_obsolete: true
replaced_by: GO:0005868

[Term]
id: GO:0001688
name: obsolete cytoplasmic dynein intermediate chain
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "cytoplasmic dynein intermediate chain" EXACT []
is_obsolete: true
replaced_by: GO:0005868

[Term]
id: GO:0001689
name: obsolete cytoplasmic dynein intermediate light chain
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "cytoplasmic dynein intermediate light chain" EXACT []
is_obsolete: true
replaced_by: GO:0005868

[Term]
id: GO:0001690
name: obsolete cytoplasmic dynein light chain
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "cytoplasmic dynein light chain" EXACT []
is_obsolete: true
replaced_by: GO:0005868

[Term]
id: GO:0001691
name: pseudophosphatase activity
namespace: molecular_function
def: "Maintains the phosphorylation state of certain molecules by associating with them and preventing them from associating with active phosphatases, and thus inhibiting the enzyme activity without interacting with the enzyme. Often pertains to proteins belonging to dual-specificity phosphatase family but lacking critical active site residues." [GOC:ajp]
is_a: GO:0019212 ! phosphatase inhibitor activity

[Term]
id: GO:0001692
name: histamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:jl, ISBN:0395825172]
synonym: "histamine metabolism" EXACT []
is_a: GO:0006576 ! cellular biogenic amine metabolic process
is_a: GO:0052803 ! imidazole-containing compound metabolic process
is_a: GO:0097164 ! ammonium ion metabolic process

[Term]
id: GO:0001694
name: histamine biosynthetic process
namespace: biological_process
alt_id: GO:0001693
def: "The chemical reactions and pathways resulting in the formation of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:jl, ISBN:0395825172]
synonym: "histamine anabolism" EXACT []
synonym: "histamine biosynthesis" EXACT []
synonym: "histamine formation" EXACT []
synonym: "histamine synthesis" EXACT []
xref: Reactome:REACT_115661 "Histidine is decarboxylated to histamine, Homo sapiens"
is_a: GO:0001692 ! histamine metabolic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0042401 ! cellular biogenic amine biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process

[Term]
id: GO:0001695
name: histamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:jl, ISBN:0395825172]
synonym: "histamine breakdown" EXACT []
synonym: "histamine catabolism" EXACT []
synonym: "histamine degradation" EXACT []
is_a: GO:0001692 ! histamine metabolic process
is_a: GO:0042135 ! neurotransmitter catabolic process
is_a: GO:0042402 ! cellular biogenic amine catabolic process
is_a: GO:0052805 ! imidazole-containing compound catabolic process

[Term]
id: GO:0001696
name: gastric acid secretion
namespace: biological_process
def: "The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion." [GOC:hjd]
synonym: "hydrochloric acid secretion" NARROW []
is_a: GO:0022600 ! digestive system process
is_a: GO:0044707 ! single-multicellular organism process
is_a: GO:0046717 ! acid secretion

[Term]
id: GO:0001697
name: histamine-induced gastric acid secretion
namespace: biological_process
def: "The regulated release of gastric acid induced by the interaction of histamine with H2 type receptor receptors with subsequent activation of adenylate cyclase and elevation of intracellular cyclic AMP." [GOC:hjd]
is_a: GO:0001696 ! gastric acid secretion

[Term]
id: GO:0001698
name: gastrin-induced gastric acid secretion
namespace: biological_process
def: "The regulated release of gastric acid induced by the interaction of gastrin with its receptor." [GOC:hjd]
is_a: GO:0001696 ! gastric acid secretion
relationship: has_part GO:0015054 ! gastrin receptor activity

[Term]
id: GO:0001699
name: acetylcholine-induced gastric acid secretion
namespace: biological_process
def: "The regulated release of gastric acid by parietal cells in response to acetylcholine." [GOC:hjd]
is_a: GO:0001696 ! gastric acid secretion
relationship: has_part GO:0015464 ! acetylcholine receptor activity
relationship: part_of GO:1905145 ! cellular response to acetylcholine

[Term]
id: GO:0001700
name: embryonic development via the syncytial blastoderm
namespace: biological_process
def: "The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
is_a: GO:0009792 ! embryo development ending in birth or egg hatching

[Term]
id: GO:0001701
name: in utero embryonic development
namespace: biological_process
def: "The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus." [GOC:go_curators, GOC:mtg_sensu]
is_a: GO:0043009 ! chordate embryonic development

[Term]
id: GO:0001702
name: gastrulation with mouth forming second
namespace: biological_process
alt_id: GO:0010003
alt_id: GO:0048276
def: "A gastrulation process in which the initial invagination becomes the anus and the mouth forms second." [GOC:go_curators, GOC:mtg_sensu]
synonym: "deuterostomic gastrulation" EXACT [GOC:dph]
is_a: GO:0007369 ! gastrulation

[Term]
id: GO:0001703
name: gastrulation with mouth forming first
namespace: biological_process
def: "A gastrulation process in which the initial invagination becomes the mouth and the anus forms second." [GOC:go_curators, GOC:mtg_sensu]
synonym: "protostomic gastrulation" NARROW [GOC:dph]
is_a: GO:0007369 ! gastrulation

[Term]
id: GO:0001704
name: formation of primary germ layer
namespace: biological_process
def: "The formation of the ectoderm, mesoderm and endoderm during gastrulation." [GOC:go_curators]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0007369 ! gastrulation

[Term]
id: GO:0001705
name: ectoderm formation
namespace: biological_process
def: "The formation of ectoderm during gastrulation." [GOC:go_curators]
is_a: GO:0001704 ! formation of primary germ layer
relationship: part_of GO:0007398 ! ectoderm development

[Term]
id: GO:0001706
name: endoderm formation
namespace: biological_process
def: "The formation of the endoderm during gastrulation." [GOC:go_curators]
synonym: "endoblast formation" NARROW [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0001704 ! formation of primary germ layer
relationship: part_of GO:0007492 ! endoderm development

[Term]
id: GO:0001707
name: mesoderm formation
namespace: biological_process
def: "The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:go_curators]
is_a: GO:0001704 ! formation of primary germ layer
relationship: part_of GO:0048332 ! mesoderm morphogenesis

[Term]
id: GO:0001708
name: cell fate specification
namespace: biological_process
def: "The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment." [GOC:go_curators]
is_a: GO:0048869 ! cellular developmental process
relationship: part_of GO:0045165 ! cell fate commitment

[Term]
id: GO:0001709
name: cell fate determination
namespace: biological_process
def: "A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [ISBN:0878932437]
xref: Wikipedia:Cell_fate_determination
is_a: GO:0048869 ! cellular developmental process
relationship: part_of GO:0045165 ! cell fate commitment

[Term]
id: GO:0001710
name: mesodermal cell fate commitment
namespace: biological_process
def: "The cell differentiation process that results in commitment of a cell to become part of the mesoderm." [GOC:go_curators, ISBN:0878932437]
synonym: "mesoderm cell fate commitment" EXACT []
is_a: GO:0060795 ! cell fate commitment involved in formation of primary germ layer
relationship: part_of GO:0048333 ! mesodermal cell differentiation

[Term]
id: GO:0001711
name: endodermal cell fate commitment
namespace: biological_process
def: "The cell differentiation process that results in commitment of a cell to become part of the endoderm." [GOC:go_curators, ISBN:0878932437]
synonym: "endoderm cell fate commitment" EXACT []
is_a: GO:0060795 ! cell fate commitment involved in formation of primary germ layer
relationship: part_of GO:0035987 ! endodermal cell differentiation

[Term]
id: GO:0001712
name: ectodermal cell fate commitment
namespace: biological_process
def: "The cell differentiation process that results in commitment of a cell to become part of the ectoderm." [GOC:go_curators, ISBN:0878932437]
synonym: "ectoderm cell fate commitment" EXACT []
is_a: GO:0060795 ! cell fate commitment involved in formation of primary germ layer
relationship: part_of GO:0001705 ! ectoderm formation
relationship: part_of GO:0010668 ! ectodermal cell differentiation

[Term]
id: GO:0001713
name: ectodermal cell fate determination
namespace: biological_process
def: "The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an ectoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators, ISBN:0878932437]
synonym: "ectoderm cell fate determination" EXACT []
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0001712 ! ectodermal cell fate commitment

[Term]
id: GO:0001714
name: endodermal cell fate specification
namespace: biological_process
def: "The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an endoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators]
synonym: "endoderm cell fate specification" EXACT []
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0001711 ! endodermal cell fate commitment

[Term]
id: GO:0001715
name: ectodermal cell fate specification
namespace: biological_process
def: "The cell fate determination process that results in a cell becoming becomes capable of differentiating autonomously into an ectoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators]
synonym: "ectoderm cell fate specification" EXACT []
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0001712 ! ectodermal cell fate commitment

[Term]
id: GO:0001716
name: L-amino-acid oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + hydrogen peroxide." [EC:1.4.3.2]
subset: gosubset_prok
synonym: "L-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.2]
synonym: "ophio-amino-acid oxidase activity" EXACT [EC:1.4.3.2]
xref: EC:1.4.3.2
xref: MetaCyc:L-AMINO-ACID-OXIDASE-RXN
xref: RHEA:13784
is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

[Term]
id: GO:0001717
name: conversion of seryl-tRNAsec to selenocys-tRNAsec
namespace: biological_process
def: "The modification process that results in the conversion of serine, carried by a specialized tRNA(ser) (which can read a UGA anticodon), to selenocysteine." [ISBN:155581073X]
subset: gosubset_prok
is_a: GO:0019988 ! charged-tRNA amino acid modification

[Term]
id: GO:0001720
name: conversion of lysyl-tRNA to pyrrolysyl-tRNA
namespace: biological_process
def: "The modification process that results in the conversion of lysine, carried by a specialized lysine-accepting tRNA (possessing a CUA anticodon), to pyrrolysine (a lysine with an amide linkage to a (4R,5R)-4-substituted pyrroline-5-carboxylate)." [PMID:12029131, PMID:12029132, PMID:12121639]
subset: gosubset_prok
is_a: GO:0019988 ! charged-tRNA amino acid modification

[Term]
id: GO:0001721
name: obsolete intermediate filament associated protein
namespace: cellular_component
def: "OBSOLETE. Proteins that associate with intermediate filaments and function in the supramolecular organization of cellular intermediate filament networks." [GOC:ajp, PMID:9484600]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "IFAP" EXACT []
synonym: "intermediate filament associated protein" EXACT []
is_obsolete: true
replaced_by: GO:0005882

[Term]
id: GO:0001722
name: obsolete type I intermediate filament associated protein
namespace: cellular_component
def: "OBSOLETE. Low molecular weight (10-45 kDa) proteins that associate with intermediate filaments by lateral binding of the filaments and have the effect of creating tight macrofilament aggregates." [GOC:ajp, PMID:9484600]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "type I intermediate filament associated protein" EXACT []
is_obsolete: true
replaced_by: GO:0005882

[Term]
id: GO:0001723
name: obsolete type II intermediate filament associated protein
namespace: cellular_component
def: "OBSOLETE. High molecular weight (100-300 kDa) proteins that associate with intermediate filaments to cross-link them into loose networks." [GOC:ajp, PMID:9484600]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "type II intermediate filament associated protein" EXACT []
is_obsolete: true
replaced_by: GO:0005882

[Term]
id: GO:0001724
name: obsolete type III intermediate filament associated protein
namespace: cellular_component
def: "OBSOLETE. Proteins that associate with the ends of intermediate filaments and couple the intermediate filaments to the plasma membrane." [GOC:ajp, PMID:9484600]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "type III intermediate filament associated protein" EXACT []
is_obsolete: true
replaced_by: GO:0045098

[Term]
id: GO:0001725
name: stress fiber
namespace: cellular_component
def: "A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber." [PMID:16651381]
synonym: "actin cable" RELATED [GOC:mah]
synonym: "stress fibre" EXACT []
is_a: GO:0042641 ! actomyosin
is_a: GO:0097517 ! contractile actin filament bundle

[Term]
id: GO:0001726
name: ruffle
namespace: cellular_component
def: "Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork." [ISBN:0124325653]
synonym: "membrane ruffle" RELATED []
is_a: GO:0042995 ! cell projection
relationship: part_of GO:0031252 ! cell leading edge

[Term]
id: GO:0001727
name: lipid kinase activity
namespace: molecular_function
def: "Catalysis of the phosphorylation of a simple or complex lipid." [GOC:hjd]
subset: gosubset_prok
is_a: GO:0016301 ! kinase activity
relationship: part_of GO:0046834 ! lipid phosphorylation

[Term]
id: GO:0001729
name: ceramide kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + ceramide = ADP + ceramide-1-phosphate." [EC:2.7.1.138]
synonym: "acylsphingosine kinase activity" EXACT [EC:2.7.1.138]
synonym: "ATP:ceramide 1-phosphotransferase activity" EXACT [EC:2.7.1.138]
xref: EC:2.7.1.138
xref: MetaCyc:CERAMIDE-KINASE-RXN
xref: Reactome:REACT_116045 "Ceramide kinase (CERK) mediates the phosphorylation of ceramide, Homo sapiens"
xref: RHEA:17932
is_a: GO:0001727 ! lipid kinase activity

[Term]
id: GO:0001730
name: 2'-5'-oligoadenylate synthetase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP = pppA(2'p5'A)n oligomers. This reaction requires the binding of double-stranded RNA." [ISBN:0198506732]
synonym: "(2-5')oligo(A) synthetase activity" EXACT []
synonym: "2'-5' oligoadenylate synthetase activity" EXACT []
synonym: "2-5A synthetase activity" EXACT []
synonym: "oligo-2',5'-adenylate synthetase activity" EXACT []
xref: MetaCyc:RXN-10798
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0001731
name: formation of translation preinitiation complex
namespace: biological_process
def: "The joining of the small ribosomal subunit, ternary complex, and mRNA." [GOC:hjd]
comment: See also the cellular component terms 'eukaryotic 43S preinitiation complex ; GO:0016282', 'eukaryotic 48S initiation complex ; GO:0033290', and their children.
subset: gosubset_prok
synonym: "formation of translation pre-initiation complex" EXACT []
synonym: "translation preinitiation complex assembly" EXACT []
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0006413 ! translational initiation

[Term]
id: GO:0001732
name: formation of cytoplasmic translation initiation complex
namespace: biological_process
def: "Joining of the large subunit, with release of IF2/eIF2 and IF3/eIF3. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site." [GOC:hjd]
subset: gosubset_prok
synonym: "cytoplasmic translation initiation complex assembly" EXACT []
synonym: "formation of translation initiation complex" BROAD []
synonym: "translation initiation complex assembly" BROAD []
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0002183 ! cytoplasmic translational initiation

[Term]
id: GO:0001733
name: galactosylceramide sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a galactosylceramide = adenosine 3',5'-bisphosphate + a galactosylceramidesulfate." [EC:2.8.2.11, PMID:10727929]
synonym: "3'-phosphoadenosine-5'-phosphosulfate-cerebroside sulfotransferase activity" EXACT [EC:2.8.2.11]
synonym: "3'-phosphoadenylyl-sulfate:galactosylceramide 3'-sulfotransferase activity" EXACT [EC:2.8.2.11]
synonym: "cerebroside sulfotransferase activity" EXACT []
synonym: "galactocerebroside sulfotransferase activity" EXACT [EC:2.8.2.11]
synonym: "galactolipid sulfotransferase activity" EXACT [EC:2.8.2.11]
synonym: "galactosylceramide sulphotransferase activity" EXACT []
synonym: "glycolipid sulfotransferase activity" EXACT [EC:2.8.2.11]
synonym: "glycosphingolipid sulfotransferase activity" EXACT [EC:2.8.2.11]
synonym: "GSase" EXACT [EC:2.8.2.11]
xref: EC:2.8.2.11
xref: MetaCyc:GALACTOSYLCERAMIDE-SULFOTRANSFERASE-RXN
xref: Reactome:REACT_115577 "Galactosylceramide sulfotransferase (GAL3ST1) mediates the sulfation of membrane glycolipids, Homo sapiens"
xref: RHEA:20616
is_a: GO:0050694 ! galactose 3-O-sulfotransferase activity

[Term]
id: GO:0001734
name: mRNA (N6-adenosine)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + RRACH = S-adenosyl-L-homocysteine + RRm6ACH; R is a purine, and H is C, A, or U." [GOC:hjd]
xref: Reactome:REACT_101890 "Internal Methylation of mRNA, Oryza sativa"
xref: Reactome:REACT_1720 "Internal Methylation of mRNA, Homo sapiens"
xref: Reactome:REACT_28538 "Internal Methylation of mRNA, Canis familiaris"
xref: Reactome:REACT_28726 "Internal Methylation of mRNA, Arabidopsis thaliana"
xref: Reactome:REACT_30916 "Internal Methylation of mRNA, Drosophila melanogaster"
xref: Reactome:REACT_32129 "Internal Methylation of mRNA, Rattus norvegicus"
xref: Reactome:REACT_85371 "Internal Methylation of mRNA, Saccharomyces cerevisiae"
xref: Reactome:REACT_88666 "Internal Methylation of mRNA, Mus musculus"
xref: Reactome:REACT_90117 "Internal Methylation of mRNA, Bos taurus"
xref: Reactome:REACT_91818 "Internal Methylation of mRNA, Plasmodium falciparum"
xref: Reactome:REACT_92618 "Internal Methylation of mRNA, Danio rerio"
xref: Reactome:REACT_96892 "Internal Methylation of mRNA, Xenopus tropicalis"
is_a: GO:0008174 ! mRNA methyltransferase activity

[Term]
id: GO:0001735
name: prenylcysteine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-prenyl-L-cysteine + O2 + H2O = a prenal + L-cysteine + H2O2." [GOC:hjd]
synonym: "prenylcysteine lyase activity" EXACT [EC:1.8.3.5]
synonym: "S-prenyl-L-cysteine:oxygen oxidoreductase activity" EXACT [EC:1.8.3.5]
xref: EC:1.8.3.5
xref: MetaCyc:1.8.3.5-RXN
is_a: GO:0016670 ! oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor

[Term]
id: GO:0001736
name: establishment of planar polarity
namespace: biological_process
def: "Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates." [GOC:dph]
synonym: "establishment of planar cell polarity" NARROW []
is_a: GO:0007164 ! establishment of tissue polarity
relationship: part_of GO:0001738 ! morphogenesis of a polarized epithelium

[Term]
id: GO:0001737
name: establishment of imaginal disc-derived wing hair orientation
namespace: biological_process
def: "Orientation of hairs in the imaginal disc-derived wing along a proximal-distal axis, such that each cell of the wing produces one wing hair which points in a distal direction." [GOC:ascb_2009, GOC:dph, GOC:mtg_sensu, GOC:tb, PMID:11239465]
synonym: "establishment of wing hair orientation" EXACT []
is_a: GO:0001736 ! establishment of planar polarity
is_a: GO:0009886 ! post-embryonic morphogenesis
relationship: part_of GO:0035317 ! imaginal disc-derived wing hair organization

[Term]
id: GO:0001738
name: morphogenesis of a polarized epithelium
namespace: biological_process
def: "The morphogenetic process in which the anatomical structures of a polarized epithelium are generated and organized. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis." [GOC:dph]
synonym: "epithelial polarization" EXACT [GOC:dph]
is_a: GO:0002009 ! morphogenesis of an epithelium

[Term]
id: GO:0001739
name: sex chromatin
namespace: cellular_component
def: "Chromatin that is part of a sex chromosome." [GOC:dos, ISBN:0198506732]
is_a: GO:0005720 ! nuclear heterochromatin
intersection_of: GO:0005720 ! nuclear heterochromatin
intersection_of: part_of GO:0000803 ! sex chromosome
relationship: part_of GO:0000803 ! sex chromosome

[Term]
id: GO:0001740
name: Barr body
namespace: cellular_component
def: "A structure found in a female mammalian cell containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery." [GOC:hjd, GOC:mr, NIF_Subcellular:sao1571698684]
xref: NIF_Subcellular:sao1571698684
xref: Wikipedia:Barr_body
is_a: GO:0000228 ! nuclear chromosome
is_a: GO:0000805 ! X chromosome
relationship: has_part GO:0098578 ! condensed chromatin of inactivated sex chromosome

[Term]
id: GO:0001741
name: XY body
namespace: cellular_component
def: "A structure found in a male mammalian spermatocyte containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery." [GOC:hjd]
is_a: GO:0000803 ! sex chromosome
relationship: has_part GO:0098578 ! condensed chromatin of inactivated sex chromosome

[Term]
id: GO:0001742
name: oenocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of an oenocyte. Oenocytes are large secretory cells found in clusters underlying the epidermis of larval abdominal segments." [GOC:go_curators]
synonym: "oenocyte cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0001743
name: optic placode formation
namespace: biological_process
def: "The initial developmental process that will lead to the formation of an eye." [GOC:dph]
is_a: GO:0060788 ! ectodermal placode formation
relationship: part_of GO:0048598 ! embryonic morphogenesis

[Term]
id: GO:0001744
name: optic lobe placode formation
namespace: biological_process
alt_id: GO:0007457
def: "Establishment of the optic placode, a thickened area of densely packed ectoderm cells directly overlying the optic vesicle in the early embryo. In Drosophila, for example, the placode appears in the dorsolateral region of the head in late stage 11 embryos and is the precursor to the larval visual system." [GOC:mtg_sensu, PMID:8402833]
synonym: "optic lobe and Bolwig's organ precursor formation" EXACT []
is_a: GO:0001743 ! optic placode formation
relationship: part_of GO:0001748 ! optic lobe placode development

[Term]
id: GO:0001745
name: compound eye morphogenesis
namespace: biological_process
def: "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu]
synonym: "insect-type retina morphogenesis" EXACT [PMID:11735386]
is_a: GO:0048592 ! eye morphogenesis
relationship: part_of GO:0048749 ! compound eye development

[Term]
id: GO:0001746
name: Bolwig's organ morphogenesis
namespace: biological_process
def: "The morphogenetic process in which the anatomical structures of the larval eye in Drosophila are generated and organized. The larval eye in Drosophila is a relatively simple sensory system composed of Bolwig's organs: two clusters, each composed of 12 photoreceptor cells from which axons extend in a single fascicle to the brain." [http://sdb.bio.purdue.edu/fly/torstoll/tailess.htm#bolwigs, PMID:6185380]
is_a: GO:0048592 ! eye morphogenesis
relationship: part_of GO:0055034 ! Bolwig's organ development

[Term]
id: GO:0001748
name: optic lobe placode development
namespace: biological_process
alt_id: GO:0048049
def: "The process whose specific outcome is the progression of the optic placode over time, from its formation to the mature structure. During embryonic stage 12 the placode starts to invaginate, forming a pouch. Cells that will form Bolwig's organ segregate from the ventral lip of this pouch, remaining in the head epidermis. The remainder of the invagination loses contact with the outer surface and becomes the optic lobe. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8402833]
synonym: "optic lobe and Bolwig's organ precursor development" EXACT []
synonym: "optic placode development" BROAD []
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development

[Term]
id: GO:0001750
name: photoreceptor outer segment
namespace: cellular_component
def: "The outer segment of a vertebrate photoreceptor that contains discs of photoreceptive membranes." [ISBN:0824072820]
is_a: GO:0031513 ! nonmotile primary cilium
is_a: GO:0097458 ! neuron part

[Term]
id: GO:0001751
name: compound eye photoreceptor cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell." [GOC:go_curators]
is_a: GO:0001754 ! eye photoreceptor cell differentiation
relationship: part_of GO:0001745 ! compound eye morphogenesis

[Term]
id: GO:0001752
name: compound eye photoreceptor fate commitment
namespace: biological_process
alt_id: GO:0007459
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a compound eye photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments." [GOC:mtg_sensu]
is_a: GO:0042706 ! eye photoreceptor cell fate commitment
relationship: part_of GO:0001751 ! compound eye photoreceptor cell differentiation

[Term]
id: GO:0001753
name: obsolete adult eye photoreceptor development (sensu Drosophila)
namespace: biological_process
def: "OBSOLETE. Development of a photoreceptor, a receptor that responds to light, in the adult Drosophila eye." [GOC:go_curators]
comment: This term was made obsolete because eye photoreceptors have completed their development by the time the adult phase begins.
synonym: "adult eye photoreceptor development (sensu Drosophila)" EXACT []
is_obsolete: true
consider: GO:0042051

[Term]
id: GO:0001754
name: eye photoreceptor cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms." [GOC:go_curators]
is_a: GO:0046530 ! photoreceptor cell differentiation
relationship: part_of GO:0048592 ! eye morphogenesis

[Term]
id: GO:0001755
name: neural crest cell migration
namespace: biological_process
def: "The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo." [GOC:ascb_2009, GOC:dph, GOC:tb, ISBN:0878932437]
is_a: GO:0001667 ! ameboidal-type cell migration
relationship: part_of GO:0014032 ! neural crest cell development

[Term]
id: GO:0001756
name: somitogenesis
namespace: biological_process
def: "The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo." [ISBN:0721662544]
synonym: "formation of mesodermal clusters" EXACT systematic_synonym []
xref: Wikipedia:Somitogenesis
is_a: GO:0009952 ! anterior/posterior pattern specification
is_a: GO:0035282 ! segmentation
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0043009 ! chordate embryonic development
relationship: part_of GO:0061053 ! somite development

[Term]
id: GO:0001757
name: somite specification
namespace: biological_process
def: "The process in which individual somites establish identity during embryogenesis." [GOC:dph]
is_a: GO:0007379 ! segment specification
is_a: GO:0009880 ! embryonic pattern specification
relationship: part_of GO:0001756 ! somitogenesis

[Term]
id: GO:0001758
name: retinal dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal." [EC:1.2.1.36]
synonym: "cytosolic retinal dehydrogenase activity" EXACT [EC:1.2.1.36]
synonym: "retinal:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.36]
xref: EC:1.2.1.36
xref: MetaCyc:RETINAL-DEHYDROGENASE-RXN
xref: RHEA:16180
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0001759
name: organ induction
namespace: biological_process
def: "The interaction of two or more cells or tissues that causes them to change their fates and specify the development of an organ." [ISBN:0878932437]
synonym: "induction of an organ" EXACT [GOC:curators]
is_a: GO:0003156 ! regulation of organ formation
is_a: GO:0031128 ! developmental induction
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0010092 ! specification of organ identity

[Term]
id: GO:0001760
name: aminocarboxymuconate-semialdehyde decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-amino-3-carboxymuconate 6-semialdehyde + H(+) = 2-aminomuconate 6-semialdehyde + CO(2)." [EC:4.1.1.45, RHEA:16560]
subset: gosubset_prok
synonym: "2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase (2-aminomuconate-semialdehyde-forming)" EXACT [EC:4.1.1.45]
synonym: "2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase activity" EXACT [EC:4.1.1.45]
synonym: "2-amino-3-(3-oxoprop-2-enyl)but-2-enedioate carboxy-lyase activity" EXACT [EC:4.1.1.45]
synonym: "ACMSD activity" EXACT [PMID:17288562]
synonym: "alpha-amino-beta-carboxymuconate-epsilon-semialdehade decarboxylase activity" EXACT [EC:4.1.1.45]
synonym: "alpha-amino-beta-carboxymuconate-epsilon-semialdehyde beta-decarboxylase activity" EXACT [EC:4.1.1.45]
synonym: "picolinic acid carboxylase activity" EXACT [EC:4.1.1.45]
synonym: "picolinic acid decarboxylase activity" EXACT [EC:4.1.1.45]
xref: EC:4.1.1.45
xref: KEGG:R04323
xref: MetaCyc:AMINO-CARBOXYMUCONATE-SEMIALDEHYDE-RXN
xref: RHEA:16560
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0001761
name: beta-alanine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of beta-alanine from one side of a membrane to the other. Beta-alanine is 3-aminopropanoic acid." [GOC:hjd]
synonym: "beta-alanine transporter activity" BROAD []
is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity
relationship: part_of GO:0001762 ! beta-alanine transport

[Term]
id: GO:0001762
name: beta-alanine transport
namespace: biological_process
def: "The directed movement of beta-alanine, 3-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:hjd]
is_a: GO:0015804 ! neutral amino acid transport

[Term]
id: GO:0001763
name: morphogenesis of a branching structure
namespace: biological_process
def: "The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes." [ISBN:0721662544]
synonym: "branching morphogenesis" EXACT [GOC:dph]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044707 ! single-multicellular organism process
is_a: GO:0044767 ! single-organism developmental process

[Term]
id: GO:0001764
name: neuron migration
namespace: biological_process
def: "The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature." [CL:0000540, GOC:go_curators]
synonym: "neuron chemotaxis" EXACT [GOC:curators]
synonym: "neuron guidance" RELATED [GOC:curators]
synonym: "neuronal migration" EXACT []
xref: Wikipedia:Neural_development#Neuron_migration
xref: Wikipedia:Neuron_migration
is_a: GO:0016477 ! cell migration
relationship: part_of GO:0048699 ! generation of neurons

[Term]
id: GO:0001765
name: membrane raft assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a membrane raft, a small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalizes cellular processes." [PMID:12648772, PMID:12803918, PMID:16645198]
synonym: "lipid raft assembly" EXACT [GOC:mah]
synonym: "lipid raft formation" RELATED []
synonym: "membrane raft formation" RELATED [GOC:mah]
is_a: GO:0031579 ! membrane raft organization
is_a: GO:0071709 ! membrane assembly

[Term]
id: GO:0001766
name: membrane raft polarization
namespace: biological_process
def: "The clustering and aggregation of membrane rafts at a single cellular pole during activation of particular cell types, such as lymphocytes." [PMID:12615889]
synonym: "lipid raft polarization" EXACT []
is_a: GO:0031580 ! membrane raft distribution

[Term]
id: GO:0001767
name: establishment of lymphocyte polarity
namespace: biological_process
def: "The directed orientation of lymphocyte signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with an appropriate activating cell." [GOC:mgi_curators, PMID:11244041, PMID:12615889]
synonym: "lymphocyte polarization" EXACT []
is_a: GO:0030010 ! establishment of cell polarity
relationship: part_of GO:0046649 ! lymphocyte activation

[Term]
id: GO:0001768
name: establishment of T cell polarity
namespace: biological_process
def: "The directed orientation of T cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with antigen presenting cell." [GOC:mgi_curators, PMID:11244041, PMID:12615889]
synonym: "establishment of T lymphocyte polarity" EXACT []
synonym: "establishment of T-cell polarity" EXACT []
synonym: "establishment of T-lymphocyte polarity" EXACT []
synonym: "T cell polarization" EXACT []
synonym: "T lymphocyte polarization" EXACT []
synonym: "T-cell polarization" EXACT []
is_a: GO:0001767 ! establishment of lymphocyte polarity
relationship: part_of GO:0042110 ! T cell activation

[Term]
id: GO:0001769
name: establishment of B cell polarity
namespace: biological_process
def: "The directed orientation of B cell signaling molecules and associated membrane rafts towards a chemokine gradient of a contact point with an antigen displaying cell." [GOC:mgi_curators, PMID:12615889, PMID:9692889]
comment: Note that 'antigen displaying cell' in this term encompasses cell types such as follicular dendritic cells which display the unprocessed antigens of a B cell, leading to activation of the B cells and antigen uptake and processing by the B cells.
synonym: "B cell polarization" EXACT []
synonym: "B lymphocyte polarization" EXACT []
synonym: "B-cell polarization" EXACT []
synonym: "establishment of B lymphocyte polarity" EXACT []
synonym: "establishment of B-cell polarity" EXACT []
synonym: "establishment of B-lymphocyte polarity" EXACT []
is_a: GO:0001767 ! establishment of lymphocyte polarity
relationship: part_of GO:0042113 ! B cell activation

[Term]
id: GO:0001770
name: establishment of natural killer cell polarity
namespace: biological_process
def: "The directed orientation of natural killer cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with a cell displaying natural killer cell activating ligands." [GOC:mgi_curators, PMID:12615886, PMID:9759849]
synonym: "establishment of NK cell polarity" EXACT []
synonym: "natural killer cell polarization" EXACT []
synonym: "NK cell polarization" EXACT []
is_a: GO:0001767 ! establishment of lymphocyte polarity
relationship: part_of GO:0030101 ! natural killer cell activation

[Term]
id: GO:0001771
name: immunological synapse formation
namespace: biological_process
def: "The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction." [GOC:mgi_curators, PMID:11244041, PMID:11376330]
synonym: "formation of immunological synapse" EXACT [GOC:curators]
is_a: GO:0009988 ! cell-cell recognition
relationship: part_of GO:0046649 ! lymphocyte activation

[Term]
id: GO:0001772
name: immunological synapse
namespace: cellular_component
def: "An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction." [GOC:mgi_curators, PMID:11244041, PMID:11376300]
synonym: "c-SMAC" NARROW [PMID:14724296]
synonym: "supramolecular activation cluster" EXACT [PMID:14724296]
xref: Wikipedia:Immunological_synapse
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0001773
name: myeloid dendritic cell activation
namespace: biological_process
def: "The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149]
is_a: GO:0002274 ! myeloid leukocyte activation

[Term]
id: GO:0001774
name: microglial cell activation
namespace: biological_process
def: "The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, PMID:10626665, PMID:10695728, PMID:12580336, PMID:9893949]
is_a: GO:0042116 ! macrophage activation

[Term]
id: GO:0001775
name: cell activation
namespace: biological_process
def: "A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:mgi_curators]
subset: goslim_pir
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0001776
name: leukocyte homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, ISBN:0781735149]
comment: Note that this term represents the return of immune system cell levels to stable numbers following an immune response as well as the proliferation and elimination of cells of the immune system required to maintain stable numbers in the absence of an outside stimulus.
synonym: "immune cell homeostasis" EXACT []
synonym: "leucocyte homeostasis" EXACT []
is_a: GO:0002376 ! immune system process
is_a: GO:0048872 ! homeostasis of number of cells

[Term]
id: GO:0001777
name: T cell homeostatic proliferation
namespace: biological_process
def: "The non-specific expansion of T cell populations within a whole or part of an organism to reach to a total number of T cells which will then remain stable over time in the absence of an external stimulus." [GOC:mgi_curators, ISBN:0781735149]
synonym: "resting T cell proliferation" EXACT []
synonym: "resting T-cell proliferation" EXACT []
synonym: "T lymphocyte homeostatic proliferation" EXACT []
synonym: "T-cell homeostatic proliferation" EXACT []
synonym: "T-lymphocyte homeostatic proliferation" EXACT []
is_a: GO:0042098 ! T cell proliferation
relationship: part_of GO:0042592 ! homeostatic process
relationship: part_of GO:0043029 ! T cell homeostasis

[Term]
id: GO:0001778
name: plasma membrane repair
namespace: biological_process
def: "The resealing of a cell plasma membrane after cellular wounding due to, for instance, mechanical stress." [GOC:add, PMID:12925704]
is_a: GO:0007009 ! plasma membrane organization
relationship: part_of GO:0042060 ! wound healing

[Term]
id: GO:0001779
name: natural killer cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a natural killer cell." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "natural killer cell development" RELATED [GOC:add]
synonym: "NK cell differentiation" EXACT []
is_a: GO:0030098 ! lymphocyte differentiation
is_a: GO:0030101 ! natural killer cell activation

[Term]
id: GO:0001780
name: neutrophil homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of neutrophils such that the total number of neutrophils within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, GOC:pr, PMID:12752675, PMID:12960266]
comment: Note that this term represents the return of neutrophil levels to stable numbers following an immune response as well as the proliferation and elimination of neutrophils required to maintain stable numbers in the absence of an outside stimulus.
is_a: GO:0001776 ! leukocyte homeostasis
is_a: GO:0002262 ! myeloid cell homeostasis

[Term]
id: GO:0001781
name: neutrophil apoptotic process
namespace: biological_process
def: "Any apoptotic process in a neutrophil, any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes." [CL:0000775, GOC:add, GOC:mtg_apoptosis, PMID:12752675, PMID:12960266]
synonym: "apoptosis of neutrophils" EXACT []
synonym: "neutrophil apoptosis" NARROW []
synonym: "neutrophil programmed cell death by apoptosis" EXACT []
synonym: "programmed cell death of neutrophils by apoptosis" EXACT []
synonym: "programmed cell death, neutrophils" EXACT []
is_a: GO:0006925 ! inflammatory cell apoptotic process
is_a: GO:0033028 ! myeloid cell apoptotic process
is_a: GO:0071887 ! leukocyte apoptotic process
relationship: part_of GO:0001780 ! neutrophil homeostasis

[Term]
id: GO:0001782
name: B cell homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, ISBN:0781735149, PMID:12956429]
comment: Note that this term represents the return of B cell levels to stable numbers following an immune response as well as the proliferation and elimination of B cells required to maintain stable numbers in the absence of an outside stimulus.
synonym: "B lymphocyte homeostasis" EXACT []
synonym: "B-cell homeostasis" EXACT []
synonym: "B-lymphocyte homeostasis" EXACT []
is_a: GO:0002260 ! lymphocyte homeostasis

[Term]
id: GO:0001783
name: B cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a B cell, a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity." [CL:0000236, GOC:add, GOC:mtg_apoptosis, ISBN:0781735149]
synonym: "apoptosis of B cells" EXACT []
synonym: "apoptosis of B lymphocytes" EXACT []
synonym: "apoptosis of B-cells" EXACT []
synonym: "apoptosis of B-lymphocytes" EXACT []
synonym: "B cell apoptosis" NARROW []
synonym: "B cell programmed cell death by apoptosis" EXACT []
synonym: "B lymphocyte apoptosis" EXACT []
synonym: "B lymphocyte programmed cell death by apoptosis" EXACT []
synonym: "B-cell apoptosis" EXACT []
synonym: "B-cell programmed cell death by apoptosis" EXACT []
synonym: "B-lymphocyte apoptosis" EXACT []
synonym: "B-lymphocyte programmed cell death by apoptosis" EXACT []
synonym: "programmed cell death of B cells by apoptosis" EXACT []
synonym: "programmed cell death of B lymphocytes by apoptosis" EXACT []
synonym: "programmed cell death of B-cells by apoptosis" EXACT []
synonym: "programmed cell death of B-lymphocytes by apoptosis" EXACT []
synonym: "programmed cell death, B cells" EXACT []
synonym: "programmed cell death, B lymphocytes" EXACT []
synonym: "programmed cell death, B-cells" EXACT []
synonym: "programmed cell death, B-lymphocytes" EXACT []
is_a: GO:0070227 ! lymphocyte apoptotic process

[Term]
id: GO:0001784
name: phosphotyrosine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein." [PMID:14636584]
is_a: GO:0045309 ! protein phosphorylated amino acid binding

[Term]
id: GO:0001785
name: prostaglandin J receptor activity
namespace: molecular_function
def: "Combining with prostaglandin J (PGJ(2)), a metabolite of prostaglandin D (PGD(2)) to initiate a change in cell activity." [PMID:12878180]
synonym: "PGJ receptor activity" RELATED []
synonym: "PGJ(2) receptor activity" EXACT []
is_a: GO:0004955 ! prostaglandin receptor activity

[Term]
id: GO:0001786
name: phosphatidylserine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine." [ISBN:0198506732, PMID:12000961]
is_a: GO:0005543 ! phospholipid binding
is_a: GO:0016597 ! amino acid binding
is_a: GO:0072341 ! modified amino acid binding
is_a: GO:0097367 ! carbohydrate derivative binding

[Term]
id: GO:0001787
name: natural killer cell proliferation
namespace: biological_process
def: "The expansion of a natural killer cell population by cell division." [GOC:add, ISBN:0781735149]
synonym: "NK cell proliferation" EXACT []
is_a: GO:0030101 ! natural killer cell activation
is_a: GO:0046651 ! lymphocyte proliferation

[Term]
id: GO:0001788
name: antibody-dependent cellular cytotoxicity
namespace: biological_process
def: "Cytolysis of target cells by natural killer cells, eosinophils, neutrophils, monocytes, or macrophages following engagement of antibodies bound to the target cells by Fc receptors on the effector cells." [GOC:pr, ISBN:0781735149, PMID:11677095, PMID:9581795]
synonym: "ADCC" EXACT []
synonym: "antibody dependent cell death" EXACT []
synonym: "antibody dependent cell killing" EXACT []
synonym: "antibody-dependent cell death" EXACT []
synonym: "antibody-dependent cell killing" EXACT []
synonym: "type VI hypersensitivity" EXACT []
xref: Wikipedia:Antibody-dependent_cell-mediated_cytotoxicity
xref: Wikipedia:Antibody-dependent_cellular_cytotoxicity
is_a: GO:0001794 ! type IIa hypersensitivity
is_a: GO:0001909 ! leukocyte mediated cytotoxicity
is_a: GO:0044699 ! single-organism process

[Term]
id: GO:0001789
name: G-protein coupled receptor signaling pathway, coupled to S1P second messenger
namespace: biological_process
def: "The series of molecular signals generated as a consequence of an adrenergic receptor binding to its physiological ligand, where the pathway proceeds with activation of sphingosine kinase and a subsequent increase in cellular levels of sphingosine-1-phosphate (S1P)." [GOC:dph, GOC:signaling, PMID:14592418]
synonym: "G protein signaling, coupled to S1P second messenger (sphingosine kinase activating)" EXACT []
synonym: "G protein signalling, coupled to S1P second messenger (sphingosine kinase activating)" EXACT []
synonym: "G-protein signalling, coupled to S1P second messenger (sphingosine kinase activating)" EXACT []
synonym: "GPCR signaling pathway via activation of sphingosine kinase activity" EXACT [GOC:signaling]
synonym: "sphingosine kinase-activating G-protein coupled receptor signaling pathway" EXACT [GOC:signaling]
synonym: "sphingosine kinase-activating GPCR signaling pathway" EXACT [GOC:signaling]
is_a: GO:0007186 ! G-protein coupled receptor signaling pathway
relationship: has_part GO:1900023 ! positive regulation of D-erythro-sphingosine kinase activity

[Term]
id: GO:0001790
name: polymeric immunoglobulin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes." [GOC:add, ISBN:0781735149]
is_a: GO:0019865 ! immunoglobulin binding

[Term]
id: GO:0001791
name: IgM binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an immunoglobulin of the IgM isotype." [GOC:add, ISBN:0781735149]
is_a: GO:0019865 ! immunoglobulin binding

[Term]
id: GO:0001792
name: polymeric immunoglobulin receptor activity
namespace: molecular_function
def: "Combining with a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]
is_a: GO:0019763 ! immunoglobulin receptor activity
relationship: has_part GO:0001790 ! polymeric immunoglobulin binding

[Term]
id: GO:0001793
name: IgM receptor activity
namespace: molecular_function
def: "Combining with an immunoglobulin of the IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]
is_a: GO:0019763 ! immunoglobulin receptor activity
relationship: has_part GO:0001791 ! IgM binding

[Term]
id: GO:0001794
name: type IIa hypersensitivity
namespace: biological_process
def: "An inflammatory response resulting in cell death mediated by activation of the classical complement pathway or induction of effector cell phagocytosis or cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell." [GOC:add, ISBN:0781735149]
comment: Note that some type IIb hypersensitivity responses (GO:0001795) are referred to simply as type II hypersensitivity in the earlier literature, but are mechanistically distinct from type IIa hypersensitivity.
is_a: GO:0002445 ! type II hypersensitivity

[Term]
id: GO:0001795
name: type IIb hypersensitivity
namespace: biological_process
def: "An inflammatory response resulting in cell death or dysfunction mediated by the direct binding of antibody to cellular receptors." [GOC:add, ISBN:0781735149]
comment: Note that some type IIa hypersensitivity response (GO:0001794) are referred to simply as type II hypersensitivity in the earlier literature, but are mechanistically distinct from type IIb hypersensitivity.
synonym: "type V hypersensitivity" EXACT []
is_a: GO:0002445 ! type II hypersensitivity

[Term]
id: GO:0001796
name: regulation of type IIa hypersensitivity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of type IIa hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149]
is_a: GO:0002892 ! regulation of type II hypersensitivity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001794 ! type IIa hypersensitivity
relationship: regulates GO:0001794 ! type IIa hypersensitivity

[Term]
id: GO:0001797
name: negative regulation of type IIa hypersensitivity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of type IIa hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149]
synonym: "down regulation of type IIa hypersensitivity" EXACT []
synonym: "down-regulation of type IIa hypersensitivity" EXACT []
synonym: "downregulation of type IIa hypersensitivity" EXACT []
synonym: "inhibition of type IIa hypersensitivity" NARROW []
is_a: GO:0001796 ! regulation of type IIa hypersensitivity
is_a: GO:0002893 ! negative regulation of type II hypersensitivity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001794 ! type IIa hypersensitivity
relationship: negatively_regulates GO:0001794 ! type IIa hypersensitivity

[Term]
id: GO:0001798
name: positive regulation of type IIa hypersensitivity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of type IIa hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149]
synonym: "activation of type IIa hypersensitivity" NARROW []
synonym: "stimulation of type IIa hypersensitivity" NARROW []
synonym: "up regulation of type IIa hypersensitivity" EXACT []
synonym: "up-regulation of type IIa hypersensitivity" EXACT []
synonym: "upregulation of type IIa hypersensitivity" EXACT []
is_a: GO:0001796 ! regulation of type IIa hypersensitivity
is_a: GO:0002894 ! positive regulation of type II hypersensitivity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001794 ! type IIa hypersensitivity
relationship: positively_regulates GO:0001794 ! type IIa hypersensitivity

[Term]
id: GO:0001799
name: regulation of type IIb hypersensitivity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of type IIb hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149]
is_a: GO:0002892 ! regulation of type II hypersensitivity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001795 ! type IIb hypersensitivity
relationship: regulates GO:0001795 ! type IIb hypersensitivity

[Term]
id: GO:0001800
name: negative regulation of type IIb hypersensitivity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of type IIb hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149]
synonym: "down regulation of type IIb hypersensitivity" EXACT []
synonym: "down-regulation of type IIb hypersensitivity" EXACT []
synonym: "downregulation of type IIb hypersensitivity" EXACT []
synonym: "inhibition of type IIb hypersensitivity" NARROW []
is_a: GO:0001799 ! regulation of type IIb hypersensitivity
is_a: GO:0002893 ! negative regulation of type II hypersensitivity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001795 ! type IIb hypersensitivity
relationship: negatively_regulates GO:0001795 ! type IIb hypersensitivity

[Term]
id: GO:0001801
name: positive regulation of type IIb hypersensitivity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of type IIb hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149]
synonym: "activation of type IIb hypersensitivity" NARROW []
synonym: "stimulation of type IIb hypersensitivity" NARROW []
synonym: "up regulation of type IIb hypersensitivity" EXACT []
synonym: "up-regulation of type IIb hypersensitivity" EXACT []
synonym: "upregulation of type IIb hypersensitivity" EXACT []
is_a: GO:0001799 ! regulation of type IIb hypersensitivity
is_a: GO:0002894 ! positive regulation of type II hypersensitivity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001795 ! type IIb hypersensitivity
relationship: positively_regulates GO:0001795 ! type IIb hypersensitivity

[Term]
id: GO:0001802
name: type III hypersensitivity
namespace: biological_process
def: "An inflammatory response resulting from recognition of immune complexes via complement or Fc receptors on effector cells leading to activation of neutrophils and other leukocytes and damage to bystander tissue." [GOC:add, ISBN:0781735149]
comment: Note that the Arthus reaction is an example of type III hypersensitivity.
xref: Wikipedia:Type_III_hypersensitivity
is_a: GO:0002444 ! myeloid leukocyte mediated immunity
is_a: GO:0002524 ! hypersensitivity
is_a: GO:0016064 ! immunoglobulin mediated immune response

[Term]
id: GO:0001803
name: regulation of type III hypersensitivity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of type III hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149]
is_a: GO:0002883 ! regulation of hypersensitivity
is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity
is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001802 ! type III hypersensitivity
relationship: regulates GO:0001802 ! type III hypersensitivity

[Term]
id: GO:0001804
name: negative regulation of type III hypersensitivity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of type III hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149]
synonym: "down regulation of type III hypersensitivity" EXACT []
synonym: "down-regulation of type III hypersensitivity" EXACT []
synonym: "downregulation of type III hypersensitivity" EXACT []
synonym: "inhibition of type III hypersensitivity" NARROW []
is_a: GO:0001803 ! regulation of type III hypersensitivity
is_a: GO:0002884 ! negative regulation of hypersensitivity
is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity
is_a: GO:0002890 ! negative regulation of immunoglobulin mediated immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001802 ! type III hypersensitivity
relationship: negatively_regulates GO:0001802 ! type III hypersensitivity

[Term]
id: GO:0001805
name: positive regulation of type III hypersensitivity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of type III hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149]
synonym: "activation of type III hypersensitivity" NARROW []
synonym: "stimulation of type III hypersensitivity" NARROW []
synonym: "up regulation of type III hypersensitivity" EXACT []
synonym: "up-regulation of type III hypersensitivity" EXACT []
synonym: "upregulation of type III hypersensitivity" EXACT []
is_a: GO:0001803 ! regulation of type III hypersensitivity
is_a: GO:0002885 ! positive regulation of hypersensitivity
is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity
is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001802 ! type III hypersensitivity
relationship: positively_regulates GO:0001802 ! type III hypersensitivity

[Term]
id: GO:0001806
name: type IV hypersensitivity
namespace: biological_process
alt_id: GO:0016069
def: "An inflammatory response driven by T cell recognition of processed soluble or cell-associated antigens leading to cytokine release and leukocyte activation." [GOC:add, ISBN:0781735149]
synonym: "delayed hypersensitivity response" EXACT []
synonym: "delayed-type hypersensitivity" EXACT []
xref: Wikipedia:Type_IV_hypersensitivity
is_a: GO:0002456 ! T cell mediated immunity
is_a: GO:0002524 ! hypersensitivity

[Term]
id: GO:0001807
name: regulation of type IV hypersensitivity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of type IV hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149]
is_a: GO:0002709 ! regulation of T cell mediated immunity
is_a: GO:0002883 ! regulation of hypersensitivity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001806 ! type IV hypersensitivity
relationship: regulates GO:0001806 ! type IV hypersensitivity

[Term]
id: GO:0001808
name: negative regulation of type IV hypersensitivity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of type IV hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149]
synonym: "down regulation of type IV hypersensitivity" EXACT []
synonym: "down-regulation of type IV hypersensitivity" EXACT []
synonym: "downregulation of type IV hypersensitivity" EXACT []
synonym: "inhibition of type IV hypersensitivity" NARROW []
is_a: GO:0001807 ! regulation of type IV hypersensitivity
is_a: GO:0002710 ! negative regulation of T cell mediated immunity
is_a: GO:0002884 ! negative regulation of hypersensitivity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001806 ! type IV hypersensitivity
relationship: negatively_regulates GO:0001806 ! type IV hypersensitivity

[Term]
id: GO:0001809
name: positive regulation of type IV hypersensitivity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of type IV hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149]
synonym: "activation of type IV hypersensitivity" NARROW []
synonym: "stimulation of type IV hypersensitivity" NARROW []
synonym: "up regulation of type IV hypersensitivity" EXACT []
synonym: "up-regulation of type IV hypersensitivity" EXACT []
synonym: "upregulation of type IV hypersensitivity" EXACT []
is_a: GO:0001807 ! regulation of type IV hypersensitivity
is_a: GO:0002711 ! positive regulation of T cell mediated immunity
is_a: GO:0002885 ! positive regulation of hypersensitivity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001806 ! type IV hypersensitivity
relationship: positively_regulates GO:0001806 ! type IV hypersensitivity

[Term]
id: GO:0001810
name: regulation of type I hypersensitivity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of type I hypersensitivity, a type of inflammatory response." [ISBN:0781735149]
is_a: GO:0002883 ! regulation of hypersensitivity
is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016068 ! type I hypersensitivity
relationship: regulates GO:0016068 ! type I hypersensitivity

[Term]
id: GO:0001811
name: negative regulation of type I hypersensitivity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of type I hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149]
synonym: "down regulation of type I hypersensitivity" EXACT []
synonym: "down-regulation of type I hypersensitivity" EXACT []
synonym: "downregulation of type I hypersensitivity" EXACT []
synonym: "inhibition of type I hypersensitivity" NARROW []
is_a: GO:0001810 ! regulation of type I hypersensitivity
is_a: GO:0002884 ! negative regulation of hypersensitivity
is_a: GO:0002890 ! negative regulation of immunoglobulin mediated immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016068 ! type I hypersensitivity
relationship: negatively_regulates GO:0016068 ! type I hypersensitivity

[Term]
id: GO:0001812
name: positive regulation of type I hypersensitivity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of type I hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149]
synonym: "activation of type I hypersensitivity" NARROW []
synonym: "stimulation of type I hypersensitivity" NARROW []
synonym: "up regulation of type I hypersensitivity" EXACT []
synonym: "up-regulation of type I hypersensitivity" EXACT []
synonym: "upregulation of type I hypersensitivity" EXACT []
is_a: GO:0001810 ! regulation of type I hypersensitivity
is_a: GO:0002885 ! positive regulation of hypersensitivity
is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016068 ! type I hypersensitivity
relationship: positively_regulates GO:0016068 ! type I hypersensitivity

[Term]
id: GO:0001813
name: regulation of antibody-dependent cellular cytotoxicity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antibody-dependent cellular cytotoxicity." [GOC:add, ISBN:0781735149]
synonym: "regulation of antibody dependent cell death" EXACT []
synonym: "regulation of antibody dependent cell killing" EXACT []
synonym: "regulation of antibody-dependent cell death" EXACT []
synonym: "regulation of antibody-dependent cell killing" EXACT []
is_a: GO:0001796 ! regulation of type IIa hypersensitivity
is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001788 ! antibody-dependent cellular cytotoxicity
relationship: regulates GO:0001788 ! antibody-dependent cellular cytotoxicity

[Term]
id: GO:0001814
name: negative regulation of antibody-dependent cellular cytotoxicity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of antibody-dependent cellular cytotoxicity." [GOC:add, ISBN:0781735149]
synonym: "down regulation of antibody-dependent cellular cytotoxicity" EXACT []
synonym: "down-regulation of antibody-dependent cellular cytotoxicity" EXACT []
synonym: "downregulation of antibody-dependent cellular cytotoxicity" EXACT []
synonym: "inhibition of antibody-dependent cellular cytotoxicity" NARROW []
synonym: "negative regulation of antibody dependent cell death" EXACT []
synonym: "negative regulation of antibody dependent cell killing" EXACT []
synonym: "negative regulation of antibody-dependent cell death" EXACT []
synonym: "negative regulation of antibody-dependent cell killing" EXACT []
is_a: GO:0001797 ! negative regulation of type IIa hypersensitivity
is_a: GO:0001813 ! regulation of antibody-dependent cellular cytotoxicity
is_a: GO:0001911 ! negative regulation of leukocyte mediated cytotoxicity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001788 ! antibody-dependent cellular cytotoxicity
relationship: negatively_regulates GO:0001788 ! antibody-dependent cellular cytotoxicity

[Term]
id: GO:0001815
name: positive regulation of antibody-dependent cellular cytotoxicity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of antibody-dependent cellular cytotoxicity." [GOC:add, ISBN:0781735149]
synonym: "activation of antibody-dependent cellular cytotoxicity" NARROW []
synonym: "positive regulation of antibody dependent cell death" EXACT []
synonym: "positive regulation of antibody dependent cell killing" EXACT []
synonym: "positive regulation of antibody-dependent cell death" EXACT []
synonym: "positive regulation of antibody-dependent cell killing" EXACT []
synonym: "stimulation of antibody-dependent cellular cytotoxicity" NARROW []
synonym: "up regulation of antibody-dependent cellular cytotoxicity" EXACT []
synonym: "up-regulation of antibody-dependent cellular cytotoxicity" EXACT []
synonym: "upregulation of antibody-dependent cellular cytotoxicity" EXACT []
is_a: GO:0001798 ! positive regulation of type IIa hypersensitivity
is_a: GO:0001813 ! regulation of antibody-dependent cellular cytotoxicity
is_a: GO:0001912 ! positive regulation of leukocyte mediated cytotoxicity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001788 ! antibody-dependent cellular cytotoxicity
relationship: positively_regulates GO:0001788 ! antibody-dependent cellular cytotoxicity

[Term]
id: GO:0001816
name: cytokine production
namespace: biological_process
def: "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149]
comment: Note that this term is intended for use when a gene product is seen to cause apparent increases in intracellular or extracellular cytokine levels, without specific regard as to whether the increase is due to increased biosynthesis, increased secretion of preexisting cytokine molecules, or increased conversion from precursor molecules.
subset: goslim_pir
synonym: "interferon production" NARROW [GOC:add, GOC:mah]
synonym: "interleukin production" NARROW [GOC:add, GOC:mah]
is_a: GO:0044707 ! single-multicellular organism process

[Term]
id: GO:0001817
name: regulation of cytokine production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of a cytokine." [GOC:add, ISBN:0781735149]
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001816 ! cytokine production
relationship: regulates GO:0001816 ! cytokine production

[Term]
id: GO:0001818
name: negative regulation of cytokine production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of production of a cytokine." [GOC:add, ISBN:0781735149]
synonym: "down regulation of cytokine production" EXACT []
synonym: "down-regulation of cytokine production" EXACT []
synonym: "downregulation of cytokine production" EXACT []
synonym: "inhibition of cytokine production" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001816 ! cytokine production
relationship: negatively_regulates GO:0001816 ! cytokine production

[Term]
id: GO:0001819
name: positive regulation of cytokine production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of production of a cytokine." [GOC:add, ISBN:0781735149]
synonym: "activation of cytokine production" NARROW []
synonym: "stimulation of cytokine production" NARROW []
synonym: "up regulation of cytokine production" EXACT []
synonym: "up-regulation of cytokine production" EXACT []
synonym: "upregulation of cytokine production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001816 ! cytokine production
relationship: positively_regulates GO:0001816 ! cytokine production

[Term]
id: GO:0001820
name: serotonin secretion
namespace: biological_process
def: "The regulated release of serotonin by a cell. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesised in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells." [GOC:ef, ISBN:0198506732, ISBN:0781735149]
synonym: "5-HT secretion" EXACT []
synonym: "5-hydroxytryptamine secretion" EXACT []
synonym: "serotonin release" RELATED [GOC:tb]
is_a: GO:0006837 ! serotonin transport
is_a: GO:0032940 ! secretion by cell

[Term]
id: GO:0001821
name: histamine secretion
namespace: biological_process
def: "The regulated release of histamine by a cell or tissue. It is formed by decarboxylation of histidine and it acts through receptors in smooth muscle and in secretory systems." [GOC:mah, ISBN:0198506732, ISBN:0781735149]
is_a: GO:0046903 ! secretion
is_a: GO:0051608 ! histamine transport

[Term]
id: GO:0001822
name: kidney development
namespace: biological_process
def: "The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine." [GOC:dph, GOC:mtg_kidney_jan10, ISBN:0124020607, ISBN:0721662544]
synonym: "nephrogenesis" RELATED [GOC:rph]
xref: Wikipedia:Kidney_development
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048513 ! animal organ development
relationship: part_of GO:0072001 ! renal system development

[Term]
id: GO:0001823
name: mesonephros development
namespace: biological_process
def: "The process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. In mammals, the mesonephros is the second of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the mesonephros will form the mature kidney." [GOC:dph, ISBN:0124020607, ISBN:0721662544, PMID:10535314]
synonym: "Wolffian body development" EXACT [GOC:dph]
is_a: GO:0001822 ! kidney development

[Term]
id: GO:0001824
name: blastocyst development
namespace: biological_process
def: "The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS5, embryo ; EMAP:23', 'TS5, inner cell mass ; EMAP:24' and 'TS5, trophectoderm; EMAP:28'.
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0001701 ! in utero embryonic development

[Term]
id: GO:0001825
name: blastocyst formation
namespace: biological_process
def: "The initial formation of a blastocyst from a solid ball of cells known as a morula." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology term 'TS3, compacted morula ; EMAP:9'.
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0001824 ! blastocyst development

[Term]
id: GO:0001826
name: inner cell mass cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an inner cell mass cell." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14'.
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0001825 ! blastocyst formation

[Term]
id: GO:0001827
name: inner cell mass cell fate commitment
namespace: biological_process
def: "The cell fate commitment of precursor cells that will become inner cell mass cells." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, compacted morula ; EMAP:13' and 'TS4, inner cell mass ; EMAP:14'.
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0001826 ! inner cell mass cell differentiation

[Term]
id: GO:0001828
name: inner cell mass cellular morphogenesis
namespace: biological_process
def: "The morphogenesis of cells in the inner cell mass." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14' and 'TS5, inner cell mass ; EMAP:24'.
is_a: GO:0000904 ! cell morphogenesis involved in differentiation
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0001826 ! inner cell mass cell differentiation

[Term]
id: GO:0001829
name: trophectodermal cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19'.
synonym: "trophectoderm cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0001825 ! blastocyst formation

[Term]
id: GO:0001830
name: trophectodermal cell fate commitment
namespace: biological_process
def: "The cell fate commitment of precursor cells that will become trophectoderm cells." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19'.
synonym: "trophectoderm cell fate commitment" EXACT []
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0001829 ! trophectodermal cell differentiation

[Term]
id: GO:0001831
name: trophectodermal cellular morphogenesis
namespace: biological_process
def: "The morphogenesis of trophectoderm cells." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'.
synonym: "trophectoderm cellular morphogenesis" EXACT []
is_a: GO:0000904 ! cell morphogenesis involved in differentiation
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0001829 ! trophectodermal cell differentiation

[Term]
id: GO:0001832
name: blastocyst growth
namespace: biological_process
def: "An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, blastocoelic cavity ; EMAP:17', 'TS5, blastocoelic cavity ; EMAP:27' and 'TS6, blastocoelic cavity ; EMAP:36'.
is_a: GO:0048589 ! developmental growth
relationship: part_of GO:0001824 ! blastocyst development

[Term]
id: GO:0001833
name: inner cell mass cell proliferation
namespace: biological_process
def: "The proliferation of cells in the inner cell mass." [GOC:dph, GOC:isa_complete, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14' and 'TS5, inner cell mass ; EMAP:24'.
is_a: GO:0008283 ! cell proliferation
relationship: part_of GO:0001832 ! blastocyst growth

[Term]
id: GO:0001834
name: trophectodermal cell proliferation
namespace: biological_process
def: "The proliferation of cells in the trophectoderm." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'.
synonym: "trophectoderm cell proliferation" EXACT []
is_a: GO:0008283 ! cell proliferation
relationship: part_of GO:0001832 ! blastocyst growth

[Term]
id: GO:0001835
name: blastocyst hatching
namespace: biological_process
def: "The hatching of the cellular blastocyst from the zona pellucida." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, zona pellucida ; EMAP:22' and 'TS5, embryo ; EMAP:23'.
is_a: GO:0035188 ! hatching
relationship: part_of GO:0001824 ! blastocyst development

[Term]
id: GO:0001836
name: release of cytochrome c from mitochondria
namespace: biological_process
def: "The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation." [GOC:add, GOC:mah, GOC:mtg_apoptosis, ISBN:0721639976, PMID:12925707, PMID:9560217]
comment: The release of cytochrome c from mitochondria is a central event in the signaling phase of the apoptotic process, and it is often used by researchers to monitor this type of cell death. Any event that induces apoptosis will at some point induce the release of cytochrome c from mitochondria. Therefore, this term should only be used to annotate gene products that are directly involved in this process. An example is Drp1 (DNM1L, UniProt symbol O00429) in PMID:20850011.
is_a: GO:0008637 ! apoptotic mitochondrial changes
relationship: part_of GO:0097190 ! apoptotic signaling pathway

[Term]
id: GO:0001837
name: epithelial to mesenchymal transition
namespace: biological_process
def: "A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:dph, PMID:14701881]
synonym: "EMT" EXACT []
synonym: "epithelial-mesenchymal transition" EXACT []
is_a: GO:0000904 ! cell morphogenesis involved in differentiation
relationship: part_of GO:0014031 ! mesenchymal cell development

[Term]
id: GO:0001838
name: embryonic epithelial tube formation
namespace: biological_process
def: "The morphogenesis of an embryonic epithelium into a tube-shaped structure." [GOC:dph, ISBN:0824072820]
is_a: GO:0072175 ! epithelial tube formation
relationship: part_of GO:0016331 ! morphogenesis of embryonic epithelium

[Term]
id: GO:0001839
name: neural plate morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the neural plate are generated and organized. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue." [GOC:dph, ISBN:0878932437]
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
relationship: part_of GO:0001840 ! neural plate development

[Term]
id: GO:0001840
name: neural plate development
namespace: biological_process
def: "The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system." [GOC:dph, GOC:ef, ISBN:0878932437, ISBN:0878932585]
is_a: GO:0060429 ! epithelium development
relationship: part_of GO:0043009 ! chordate embryonic development

[Term]
id: GO:0001841
name: neural tube formation
namespace: biological_process
alt_id: GO:0001679
def: "The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system." [GOC:dph, ISBN:0878932437]
synonym: "neural tube morphogenesis" EXACT [GOC:dph]
synonym: "neurulation" EXACT []
xref: Wikipedia:Neurulation
is_a: GO:0001838 ! embryonic epithelial tube formation
relationship: part_of GO:0021915 ! neural tube development

[Term]
id: GO:0001842
name: neural fold formation
namespace: biological_process
def: "The process in which the neural fold is formed. The edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove." [GOC:dph, ISBN:0878932437]
synonym: "neural groove formation" RELATED [GOC:dph]
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
is_a: GO:0060571 ! morphogenesis of an epithelial fold
relationship: part_of GO:0014020 ! primary neural tube formation

[Term]
id: GO:0001843
name: neural tube closure
namespace: biological_process
def: "The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline." [GOC:dph, ISBN:0878932437]
is_a: GO:0060606 ! tube closure
relationship: part_of GO:0014020 ! primary neural tube formation

[Term]
id: GO:0001844
name: protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
namespace: biological_process
def: "The process in which a protein is incorporated into a mitochondrial membrane as the initial phase of the mitochondrial membrane permeabilization that takes place in the apoptotic signaling pathway." [GOC:add, GOC:mtg_apoptosis, PMID:12952892]
comment: Note that this term is intended to cover the insertion of pro-apoptotic proteins such as Bax or its homologs into mitochondrial membranes which occurs as an early step in the apoptotic program.
synonym: "insertion of proteins into mitochondrial membranes during the induction of apoptosis" NARROW []
synonym: "protein insertion into mitochondrial membrane during induction of apoptosis" NARROW [GOC:dph, GOC:tb]
synonym: "protein insertion into mitochondrial membrane involved in induction of apoptosis" NARROW []
synonym: "protein insertion into mitochondrion membrane during induction of apoptosis" NARROW []
xref: Reactome:REACT_101395 "Translocation of BMF to mitochondria, Gallus gallus"
xref: Reactome:REACT_101818 "Translocation of BIM to mitochondria, Sus scrofa"
xref: Reactome:REACT_102379 "Translocation of BIM to mitochondria, Bos taurus"
xref: Reactome:REACT_104 "Translocation of PUMA protein to mitochondria, Homo sapiens"
xref: Reactome:REACT_105818 "Translocation of BIM to mitochondria, Rattus norvegicus"
xref: Reactome:REACT_105883 "Translocation of activated BAD protein to mitochondria, Bos taurus"
xref: Reactome:REACT_109143 "Translocation of activated BAX to the mitochondria, Danio rerio"
xref: Reactome:REACT_110253 "Translocation of BMF to mitochondria, Taeniopygia guttata"
xref: Reactome:REACT_110902 "Translocation of activated BAD protein to mitochondria, Sus scrofa"
xref: Reactome:REACT_112264 "Translocation of activated BAD protein to mitochondria, Xenopus tropicalis"
xref: Reactome:REACT_112484 "Translocation of NOXA to mitochondria, Mus musculus"
xref: Reactome:REACT_112773 "Translocation of NOXA to mitochondria, Rattus norvegicus"
xref: Reactome:REACT_113120 "Translocation of BIM to mitochondria, Xenopus tropicalis"
xref: Reactome:REACT_113968 "Translocation of NOXA to mitochondria, Sus scrofa"
xref: Reactome:REACT_115488 "Translocation of NOXA to mitochondria, Canis familiaris"
xref: Reactome:REACT_1286 "Translocation of activated BAX to the mitochondria, Homo sapiens"
xref: Reactome:REACT_1585 "Translocation of NOXA to mitochondria, Homo sapiens"
xref: Reactome:REACT_2046 "Translocation of activated BAD protein to mitochondria, Homo sapiens"
xref: Reactome:REACT_32202 "Translocation of activated BAX to the mitochondria, Xenopus tropicalis"
xref: Reactome:REACT_32704 "Translocation of activated BAD protein to mitochondria, Canis familiaris"
xref: Reactome:REACT_600 "Translocation of BMF to mitochondria, Homo sapiens"
xref: Reactome:REACT_750 "Translocation of BIM to mitochondria, Homo sapiens"
xref: Reactome:REACT_78961 "Translocation of activated BAD protein to mitochondria, Danio rerio"
xref: Reactome:REACT_81932 "Translocation of activated BAX to the mitochondria, Bos taurus"
xref: Reactome:REACT_83771 "Translocation of BMF to mitochondria, Bos taurus"
xref: Reactome:REACT_85921 "Translocation of BIM to mitochondria, Canis familiaris"
xref: Reactome:REACT_87251 "Translocation of activated BAD protein to mitochondria, Rattus norvegicus"
xref: Reactome:REACT_87865 "Translocation of activated BAX to the mitochondria, Rattus norvegicus"
xref: Reactome:REACT_89314 "Translocation of BMF to mitochondria, Rattus norvegicus"
xref: Reactome:REACT_91622 "Translocation of activated BAD protein to mitochondria, Mus musculus"
xref: Reactome:REACT_92580 "Translocation of activated BAX to the mitochondria, Mus musculus"
xref: Reactome:REACT_94530 "Translocation of BMF to mitochondria, Mus musculus"
xref: Reactome:REACT_95929 "Translocation of BIM to mitochondria, Mus musculus"
xref: Reactome:REACT_97369 "Translocation of activated BAX to the mitochondria, Taeniopygia guttata"
xref: Reactome:REACT_97409 "Translocation of activated BAX to the mitochondria, Sus scrofa"
xref: Reactome:REACT_97453 "Translocation of BMF to mitochondria, Canis familiaris"
xref: Reactome:REACT_99030 "Translocation of activated BAX to the mitochondria, Canis familiaris"
xref: Reactome:REACT_99700 "Translocation of BMF to mitochondria, Xenopus tropicalis"
is_a: GO:0051204 ! protein insertion into mitochondrial membrane
intersection_of: GO:0051204 ! protein insertion into mitochondrial membrane
intersection_of: part_of GO:0097190 ! apoptotic signaling pathway
relationship: part_of GO:0097190 ! apoptotic signaling pathway
relationship: part_of GO:0097345 ! mitochondrial outer membrane permeabilization

[Term]
id: GO:0001845
name: phagolysosome assembly
namespace: biological_process
def: "The process that results in the fusion of a phagosome, a vesicle formed by phagocytosis, with a lysosome." [GOC:add, ISBN:0781735149]
synonym: "late phagosome biosynthesis" RELATED []
synonym: "late phagosome formation" RELATED []
synonym: "phagolysosome formation" RELATED [GOC:mah]
is_a: GO:0007040 ! lysosome organization
is_a: GO:0016050 ! vesicle organization
is_a: GO:0070925 ! organelle assembly
relationship: part_of GO:0006909 ! phagocytosis
relationship: part_of GO:0090382 ! phagosome maturation

[Term]
id: GO:0001846
name: opsonin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an opsonin, such as a complement component or antibody, deposited on the surface of a bacteria, virus, immune complex, or other particulate material." [GOC:add, ISBN:0781735149]
comment: Note that an opsonin is a blood serum protein or fragment which when deposited on the surface of a bacteria, virus, immune complex, or other particulate material acts a signal for phagocytosis to cells bearing the appropriate receptors. Not all complement components or fragments and not all antibodies have opsonic properties.
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0001847
name: opsonin receptor activity
namespace: molecular_function
def: "Combining with an opsonin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]
is_a: GO:0004888 ! transmembrane signaling receptor activity
relationship: has_part GO:0001846 ! opsonin binding

[Term]
id: GO:0001848
name: complement binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any component or product of the complement cascade." [GOC:add, ISBN:0781735149]
comment: Note that the complement cascade includes all of the components involved in the classical complement pathway, the alternative complement pathway, and the lectin complement pathway, as well as the common components of all three pathways.
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0001849
name: complement component C1q binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the C1q component of the classical complement cascade." [GOC:add, ISBN:0781735149]
is_a: GO:0001846 ! opsonin binding
is_a: GO:0001848 ! complement binding

[Term]
id: GO:0001850
name: complement component C3a binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the C3a product of the complement cascade." [GOC:add, ISBN:0781735149]
is_a: GO:0001848 ! complement binding

[Term]
id: GO:0001851
name: complement component C3b binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the C3b product of the complement cascade." [GOC:add, ISBN:0781735149]
is_a: GO:0001846 ! opsonin binding
is_a: GO:0001848 ! complement binding

[Term]
id: GO:0001852
name: complement component iC3b binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the iC3b product of the complement cascade." [GOC:add, ISBN:0781735149]
is_a: GO:0001846 ! opsonin binding
is_a: GO:0001848 ! complement binding

[Term]
id: GO:0001853
name: complement component C3dg binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the C3dg product of the complement cascade." [GOC:add, ISBN:0781735149]
is_a: GO:0001848 ! complement binding

[Term]
id: GO:0001854
name: complement component C3d binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the C3d product of the complement cascade." [GOC:add, ISBN:0781735149]
is_a: GO:0001848 ! complement binding

[Term]
id: GO:0001855
name: complement component C4b binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the C4b product of the classical complement cascade." [GOC:add, ISBN:0781735149]
is_a: GO:0001846 ! opsonin binding
is_a: GO:0001848 ! complement binding

[Term]
id: GO:0001856
name: complement component C5a binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the C5a product of the complement cascade." [GOC:add, ISBN:0781735149]
is_a: GO:0001848 ! complement binding

[Term]
id: GO:0001857
name: complement component C1q receptor activity
namespace: molecular_function
def: "Combining with the C1q component of the classical complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]
is_a: GO:0001847 ! opsonin receptor activity
is_a: GO:0004875 ! complement receptor activity
relationship: has_part GO:0001849 ! complement component C1q binding

[Term]
id: GO:0001858
name: complement component iC3b receptor activity
namespace: molecular_function
def: "Combining with the iC3b product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]
is_a: GO:0001847 ! opsonin receptor activity
is_a: GO:0004875 ! complement receptor activity
relationship: has_part GO:0001852 ! complement component iC3b binding

[Term]
id: GO:0001859
name: complement component C3dg receptor activity
namespace: molecular_function
def: "Combining with the C3dg product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]
is_a: GO:0004875 ! complement receptor activity
relationship: has_part GO:0001853 ! complement component C3dg binding

[Term]
id: GO:0001860
name: complement component C3d receptor activity
namespace: molecular_function
def: "Combining with the C3d product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]
is_a: GO:0004875 ! complement receptor activity
relationship: has_part GO:0001854 ! complement component C3d binding

[Term]
id: GO:0001861
name: complement component C4b receptor activity
namespace: molecular_function
def: "Combining with the C4b product of the classical complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]
is_a: GO:0001847 ! opsonin receptor activity
is_a: GO:0004875 ! complement receptor activity
relationship: has_part GO:0001855 ! complement component C4b binding

[Term]
id: GO:0001862
name: collectin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a collectin, a member of a group of structurally related pattern recognition molecules characterized by having a carbohydrate recognition domain of the C-type lectin family at the C-terminus and a collagenous domain at the N-terminus." [GOC:add, ISBN:0781735149]
comment: Note that collectins include such proteins as mannose-binding lectins (MBL) and surfactant proteins A and D (SP-A and SP-D).
is_a: GO:0001846 ! opsonin binding

[Term]
id: GO:0001863
name: collectin receptor activity
namespace: molecular_function
def: "Combining with a collectin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]
comment: Note that collectins include such proteins as mannose-binding lectin (MBL) and surfactant proteins A and D (SP-A and SP-D).
is_a: GO:0001847 ! opsonin receptor activity
relationship: has_part GO:0001862 ! collectin binding

[Term]
id: GO:0001864
name: pentraxin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a pentraxin, a member of a family of inflammatory proteins with a radially symmetric arrangement of five identical, noncovalently linked chains in a pentagonal array." [GOC:add, ISBN:0781735149]
comment: Note that pentraxins include such proteins as serum amyloid P component (SAP) and C-reactive protein (CRP).
is_a: GO:0001846 ! opsonin binding

[Term]
id: GO:0001865
name: NK T cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a NK T cell." [GOC:add, ISBN:0781735149, PMID:10704459]
comment: Note that NK T cells are a distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments. Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "natural killer T cell differentiation" EXACT []
synonym: "natural T cell differentiation" EXACT []
synonym: "NK T cell development" RELATED [GOC:add]
synonym: "NK T lymphocyte differentiation" EXACT []
synonym: "NK T-cell differentiation" EXACT []
synonym: "NK T-lymphocyte differentiation" EXACT []
synonym: "NKT cell differentiation" EXACT []
synonym: "NT cell differentiation" EXACT []
is_a: GO:0046632 ! alpha-beta T cell differentiation

[Term]
id: GO:0001866
name: NK T cell proliferation
namespace: biological_process
def: "The expansion of a NK T cell population by cell division." [GOC:add, ISBN:0781735149, PMID:10704459]
comment: Note that NK T cells are a distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments.
synonym: "natural killer T cell proliferation" EXACT []
synonym: "natural T cell proliferation" EXACT []
synonym: "NK T lymphocyte proliferation" EXACT []
synonym: "NK T-cell proliferation" EXACT []
synonym: "NK T-lymphocyte proliferation" EXACT []
synonym: "NKT cell proliferation" EXACT []
synonym: "NT cell proliferation" EXACT []
is_a: GO:0046633 ! alpha-beta T cell proliferation
is_a: GO:0051132 ! NK T cell activation

[Term]
id: GO:0001867
name: complement activation, lectin pathway
namespace: biological_process
def: "Any process involved in the activation of any of the steps of the lectin pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes." [GOC:add, ISBN:0781735149]
comment: Note that proteins such as mannose-binding lectin (MBL) and certain serum ficolins can activate the lectin complement pathway.
synonym: "complement cascade, lectin pathway" EXACT [GOC:add]
xref: Reactome:REACT_114752 "Lectin pathway of complement activation, Canis familiaris"
xref: Reactome:REACT_30334 "Lectin pathway of complement activation, Rattus norvegicus"
xref: Reactome:REACT_31122 "Lectin pathway of complement activation, Bos taurus"
xref: Reactome:REACT_33084 "Lectin pathway of complement activation, Mus musculus"
xref: Reactome:REACT_7964 "Lectin pathway of complement activation, Homo sapiens"
xref: Reactome:REACT_89631 "Lectin pathway of complement activation, Sus scrofa"
xref: Reactome:REACT_96749 "Lectin pathway of complement activation, Gallus gallus"
is_a: GO:0006956 ! complement activation
is_a: GO:0045087 ! innate immune response

[Term]
id: GO:0001868
name: regulation of complement activation, lectin pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the lectin pathway of complement activation." [GOC:add, ISBN:0781735149]
synonym: "regulation of complement cascade, lectin pathway" EXACT [GOC:add]
is_a: GO:0030449 ! regulation of complement activation
is_a: GO:0045088 ! regulation of innate immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001867 ! complement activation, lectin pathway
relationship: regulates GO:0001867 ! complement activation, lectin pathway

[Term]
id: GO:0001869
name: negative regulation of complement activation, lectin pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of complement activation by the lectin pathway." [GOC:add, ISBN:0781735149]
synonym: "down regulation of complement activation, lectin pathway" EXACT []
synonym: "down-regulation of complement activation, lectin pathway" EXACT []
synonym: "downregulation of complement activation, lectin pathway" EXACT []
synonym: "inhibition of complement activation, lectin pathway" NARROW []
synonym: "negative regulation of complement cascade, lectin pathway" EXACT [GOC:add]
is_a: GO:0001868 ! regulation of complement activation, lectin pathway
is_a: GO:0045824 ! negative regulation of innate immune response
is_a: GO:0045916 ! negative regulation of complement activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001867 ! complement activation, lectin pathway
relationship: negatively_regulates GO:0001867 ! complement activation, lectin pathway

[Term]
id: GO:0001870
name: positive regulation of complement activation, lectin pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of complement activation by the lectin pathway." [GOC:add, ISBN:0781735149]
synonym: "activation of complement activation, lectin pathway" NARROW []
synonym: "positive regulation of complement cascade, lectin pathway" EXACT [GOC:add]
synonym: "stimulation of complement activation, lectin pathway" NARROW []
synonym: "up regulation of complement activation, lectin pathway" EXACT []
synonym: "up-regulation of complement activation, lectin pathway" EXACT []
synonym: "upregulation of complement activation, lectin pathway" EXACT []
is_a: GO:0001868 ! regulation of complement activation, lectin pathway
is_a: GO:0045089 ! positive regulation of innate immune response
is_a: GO:0045917 ! positive regulation of complement activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001867 ! complement activation, lectin pathway
relationship: positively_regulates GO:0001867 ! complement activation, lectin pathway

[Term]
id: GO:0001871
name: pattern binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a repeating or polymeric structure, such as a polysaccharide or peptidoglycan." [PMID:12072369, PMID:12225919, PMID:12507420, PMID:12925128, PMID:14523544]
comment: Note that this term and its child terms are intended for annotation of gene products which function to recognize (bind) the repeating structural units such as polysaccharides or peptidoglycans commonly found in microbial cell walls and virions. If such binding is coupled to signal transduction, use 'pattern recognition receptor activity ; GO:0008329' instead.
subset: goslim_pir
subset: gosubset_prok
synonym: "pattern recognition activity" BROAD []
is_a: GO:0005488 ! binding

[Term]
id: GO:0001872
name: (1->3)-beta-D-glucan binding
namespace: molecular_function
alt_id: GO:0080087
def: "Interacting selectively and non-covalently with (1->3)-beta-D-glucans." [PMID:14707091]
synonym: "1,3-beta-D-glucan binding" EXACT []
synonym: "callose binding" NARROW []
synonym: "zymosan binding" NARROW [GOC:tb]
is_a: GO:0030247 ! polysaccharide binding

[Term]
id: GO:0001873
name: polysaccharide receptor activity
namespace: molecular_function
def: "Combining with a polysaccharide and transmitting the signal to initiate a change in cell activity. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [CHEBI:18154, PMID:14707091]
is_a: GO:0008329 ! signaling pattern recognition receptor activity
relationship: has_part GO:0030247 ! polysaccharide binding

[Term]
id: GO:0001874
name: (1->3)-beta-D-glucan receptor activity
namespace: molecular_function
def: "Combining with (1->3)-beta-D-glucans to initiate a change in cell activity." [PMID:14707091]
synonym: "(1,3)-beta-D-glucan receptor activity" EXACT []
synonym: "1,3-beta-D-glucan receptor activity" EXACT []
synonym: "beta-1,3-D-glucan receptor activity" EXACT []
synonym: "zymosan receptor activity" NARROW [GOC:tb]
is_a: GO:0001873 ! polysaccharide receptor activity
relationship: has_part GO:0001872 ! (1->3)-beta-D-glucan binding

[Term]
id: GO:0001875
name: lipopolysaccharide receptor activity
namespace: molecular_function
def: "Combining with a lipopolysaccharide and transmitting the signal across the cell membrane to initiate a change in cell activity. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system." [PMID:14609719, PMID:15379975]
synonym: "endotoxin receptor activity" BROAD []
synonym: "LPS receptor activity" EXACT []
is_a: GO:0008329 ! signaling pattern recognition receptor activity
relationship: has_part GO:0001530 ! lipopolysaccharide binding
relationship: part_of GO:0031663 ! lipopolysaccharide-mediated signaling pathway

[Term]
id: GO:0001876
name: lipoarabinomannan binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with lipoarabinomannan." [PMID:10586073]
synonym: "LAM binding" EXACT []
is_a: GO:0001871 ! pattern binding
is_a: GO:0034235 ! GPI anchor binding

[Term]
id: GO:0001877
name: lipoarabinomannan receptor activity
namespace: molecular_function
def: "Combining with lipoarabinomannan and transmitting the signal to initiate a change in cell activity." [PMID:10586073]
synonym: "LAM receptor activity" EXACT []
is_a: GO:0008329 ! signaling pattern recognition receptor activity
relationship: has_part GO:0001876 ! lipoarabinomannan binding

[Term]
id: GO:0001878
name: response to yeast
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a yeast species." [PMID:14707091]
comment: defined as response to Saccharomycotina (true yeasts).  This excludes fission yeast.
is_a: GO:0009620 ! response to fungus

[Term]
id: GO:0001879
name: detection of yeast
namespace: biological_process
def: "The series of events in which a stimulus from a yeast is received and converted into a molecular signal." [PMID:14707091]
is_a: GO:0001878 ! response to yeast
is_a: GO:0016046 ! detection of fungus

[Term]
id: GO:0001880
name: Mullerian duct regression
namespace: biological_process
def: "The process in which the Mullerian ducts, primordia of the oviducts, uterus and upper vagina, undergo regression in male embryos." [GOC:dph, PMID:12368913]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0060033 ! anatomical structure regression
relationship: part_of GO:0046661 ! male sex differentiation

[Term]
id: GO:0001881
name: receptor recycling
namespace: biological_process
def: "The process that results in the return of receptor molecules to an active state and an active cellular location after they have been stimulated by a ligand. An active state is when the receptor is ready to receive a signal." [GOC:dph]
is_a: GO:0043112 ! receptor metabolic process
relationship: part_of GO:0023051 ! regulation of signaling

[Term]
id: GO:0001882
name: nucleoside binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a nucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked either to ribose or deoxyribose." [GOC:hjd]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0036094 ! small molecule binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:0097367 ! carbohydrate derivative binding
is_a: GO:1901363 ! heterocyclic compound binding

[Term]
id: GO:0001883
name: purine nucleoside binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a purine nucleoside, a compound consisting of a purine base linked either to ribose or deoxyribose." [GOC:hjd]
is_a: GO:0001882 ! nucleoside binding

[Term]
id: GO:0001884
name: pyrimidine nucleoside binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a pyrimidine nucleoside, a compound consisting of a pyrimidine base linked either to ribose or deoxyribose." [GOC:hjd]
is_a: GO:0001882 ! nucleoside binding

[Term]
id: GO:0001885
name: endothelial cell development
namespace: biological_process
def: "The progression of an endothelial cell over time, from its formation to the mature structure." [GOC:dph]
is_a: GO:0002064 ! epithelial cell development
relationship: part_of GO:0003158 ! endothelium development
relationship: part_of GO:0045446 ! endothelial cell differentiation

[Term]
id: GO:0001886
name: endothelial cell morphogenesis
namespace: biological_process
def: "The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003382 ! epithelial cell morphogenesis
relationship: part_of GO:0001885 ! endothelial cell development

[Term]
id: GO:0001887
name: selenium compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving compounds that contain selenium, such as selenocysteine." [PMID:12730456]
subset: gosubset_prok
synonym: "selenium compound metabolism" EXACT []
synonym: "selenium metabolic process" EXACT []
synonym: "selenium metabolism" EXACT []
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0001888
name: glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan = UDP + alpha-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan." [EC:2.4.1.223]
synonym: "alpha-1,4-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.223]
synonym: "alpha-N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.223]
synonym: "alpha1,4-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.223]
synonym: "glucuronosylgalactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.223]
synonym: "UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1,3)-beta-D-galactosyl-(1,3)-beta-D-galactosyl-(1,4)-beta-D-xylosyl-proteoglycan 4IV-alpha-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.223]
synonym: "UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan 4IV-alpha-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.223]
xref: EC:2.4.1.223
xref: MetaCyc:2.4.1.223-RXN
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0001889
name: liver development
namespace: biological_process
def: "The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes." [GOC:add, ISBN:068340007X]
is_a: GO:0048732 ! gland development
relationship: part_of GO:0061008 ! hepaticobiliary system development

[Term]
id: GO:0001890
name: placenta development
namespace: biological_process
def: "The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin." [GOC:add, ISBN:068340007X]
synonym: "placental development" EXACT []
synonym: "placentation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048513 ! animal organ development
is_a: GO:0048608 ! reproductive structure development

[Term]
id: GO:0001891
name: phagocytic cup
namespace: cellular_component
def: "An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome." [PMID:10358769]
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0001892
name: embryonic placenta development
namespace: biological_process
def: "The embryonically driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin." [GOC:add, ISBN:068340007X]
synonym: "fetal placenta development" EXACT [GOC:dph]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0048568 ! embryonic organ development
relationship: part_of GO:0001701 ! in utero embryonic development
relationship: part_of GO:0001890 ! placenta development

[Term]
id: GO:0001893
name: maternal placenta development
namespace: biological_process
def: "Maternally driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin." [GOC:add, ISBN:068340007X]
synonym: "decidua development" RELATED [GOC:dph]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048608 ! reproductive structure development
is_a: GO:0060135 ! maternal process involved in female pregnancy
relationship: part_of GO:0001890 ! placenta development

[Term]
id: GO:0001894
name: tissue homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function." [GOC:add, GOC:isa_complete]
synonym: "tissue maintenance" NARROW [GOC:add]
is_a: GO:0060249 ! anatomical structure homeostasis
relationship: part_of GO:0048871 ! multicellular organismal homeostasis

[Term]
id: GO:0001895
name: retina homeostasis
namespace: biological_process
def: "A tissue homeostatic process involved in the maintenance of an internal equilibrium within the retina of the eye, including control of cellular proliferation and death and control of metabolic function." [GOC:add, GOC:dph, GOC:tb, PMID:15365173, PMID:15365178]
is_a: GO:0001894 ! tissue homeostasis

[Term]
id: GO:0001896
name: autolysis
namespace: biological_process
def: "The spontaneous death by lysis of bacteria in response to environmental conditions." [GOC:add]
subset: gosubset_prok
xref: Wikipedia:Autolysis
is_a: GO:0019835 ! cytolysis
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0001897
name: cytolysis by symbiont of host cells
namespace: biological_process
def: "The killing by an organism of a cell in its host organism by means of the rupture of cell membranes and the loss of cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add]
subset: gosubset_prok
synonym: "cytolysis by organism of host cells" EXACT []
is_a: GO:0001907 ! killing by symbiont of host cells
is_a: GO:0051801 ! cytolysis in other organism involved in symbiotic interaction
relationship: has_part GO:0052025 ! modification by symbiont of host cell membrane

[Term]
id: GO:0001898
name: regulation of cytolysis by symbiont of host cells
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of the cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add, GOC:dph, GOC:tb]
subset: gosubset_prok
synonym: "regulation by symbiont of cytolysis of host cells" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051802 ! regulation of cytolysis in other organism involved in symbiotic interaction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001897 ! cytolysis by symbiont of host cells
relationship: regulates GO:0001897 ! cytolysis by symbiont of host cells

[Term]
id: GO:0001899
name: negative regulation of cytolysis by symbiont of host cells
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add, GOC:dph, GOC:tb]
subset: gosubset_prok
synonym: "down regulation by symbiont of cytolysis of host cells" EXACT []
synonym: "down-regulation by symbiont of cytolysis of host cells" EXACT []
synonym: "downregulation by symbiont of cytolysis of host cells" EXACT []
synonym: "inhibition by symbiont of cytolysis of host cells" NARROW []
synonym: "negative regulation by symbiont of cytolysis of host cells" EXACT [GOC:dph, GOC:tb]
is_a: GO:0001898 ! regulation of cytolysis by symbiont of host cells
is_a: GO:0051803 ! negative regulation of cytolysis in other organism involved in symbiotic interaction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001897 ! cytolysis by symbiont of host cells
relationship: negatively_regulates GO:0001897 ! cytolysis by symbiont of host cells

[Term]
id: GO:0001900
name: positive regulation of cytolysis by symbiont of host cells
namespace: biological_process
def: "Any process in which an organism activates or increases the frequency, rate or extent of cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add, GOC:dph, GOC:tb]
subset: gosubset_prok
synonym: "activation by symbiont of cytolysis of host cells" NARROW []
synonym: "positive regulation by symbiont of cytolysis of host cells" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation by symbiont of cytolysis of host cells" NARROW []
synonym: "up regulation by symbiont of cytolysis of host cells" EXACT []
synonym: "up-regulation by symbiont of cytolysis of host cells" EXACT []
synonym: "upregulation by symbiont of cytolysis of host cells" EXACT []
is_a: GO:0001898 ! regulation of cytolysis by symbiont of host cells
is_a: GO:0051804 ! positive regulation of cytolysis in other organism involved in symbiotic interaction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001897 ! cytolysis by symbiont of host cells
relationship: positively_regulates GO:0001897 ! cytolysis by symbiont of host cells

[Term]
id: GO:0001905
name: activation of membrane attack complex
namespace: biological_process
def: "The activation of the membrane attack complex components of the complement cascade which can result in death of a target cell through cytolysis." [GOC:add, ISBN:0781735149]
synonym: "activation of MAC" EXACT []
synonym: "activation of TCC" NARROW []
synonym: "activation of terminal complement complex" NARROW [GOC:add]
synonym: "activation of the terminal complement cascade" NARROW []
synonym: "MAC assembly" EXACT [GOC:rl]
synonym: "MAC formation" EXACT [GOC:rl]
synonym: "membrane attack complex assembly" EXACT [GOC:rl]
synonym: "membrane attack complex formation" EXACT [GOC:rl]
is_a: GO:0006956 ! complement activation

[Term]
id: GO:0001906
name: cell killing
namespace: biological_process
def: "Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions." [GOC:add]
subset: goslim_pir
subset: gosubset_prok
synonym: "necrosis" RELATED []
is_a: GO:0008150 ! biological_process
disjoint_from: GO:0044848 ! biological phase

[Term]
id: GO:0001907
name: killing by symbiont of host cells
namespace: biological_process
def: "Any process mediated by an organism that results in the death of cells in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add]
subset: gosubset_prok
is_a: GO:0044004 ! disruption by symbiont of host cell
is_a: GO:0051883 ! killing of cells in other organism involved in symbiotic interaction

[Term]
id: GO:0001909
name: leukocyte mediated cytotoxicity
namespace: biological_process
def: "The directed killing of a target cell by a leukocyte." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149, PMID:11911826]
comment: This term was improved by GO_REF:0000022. It was moved. Note that this term and its children describe contact-dependent killing of target cells by lymphocytes and myeloid cells of the immune system.
synonym: "immune cell mediated cell death" EXACT []
synonym: "immune cell mediated cell killing" EXACT []
synonym: "immune cell mediated cytotoxicity" EXACT []
synonym: "leucocyte mediated cytotoxicity" EXACT []
is_a: GO:0001906 ! cell killing
is_a: GO:0002443 ! leukocyte mediated immunity

[Term]
id: GO:0001910
name: regulation of leukocyte mediated cytotoxicity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of leukocyte mediated cytotoxicity." [GOC:add, ISBN:0781735149, PMID:11911826]
synonym: "regulation of immune cell mediated cell death" EXACT []
synonym: "regulation of immune cell mediated cell killing" EXACT []
synonym: "regulation of immune cell mediated cytotoxicity" EXACT []
synonym: "regulation of leucocyte mediated cytotoxicity" EXACT []
is_a: GO:0002703 ! regulation of leukocyte mediated immunity
is_a: GO:0031341 ! regulation of cell killing
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001909 ! leukocyte mediated cytotoxicity
relationship: regulates GO:0001909 ! leukocyte mediated cytotoxicity

[Term]
id: GO:0001911
name: negative regulation of leukocyte mediated cytotoxicity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of leukocyte mediated cytotoxicity." [GOC:add, ISBN:0781735149, PMID:11911826]
synonym: "down regulation of leukocyte mediated cytotoxicity" EXACT []
synonym: "down-regulation of leukocyte mediated cytotoxicity" EXACT []
synonym: "downregulation of leukocyte mediated cytotoxicity" EXACT []
synonym: "inhibition of leukocyte mediated cytotoxicity" NARROW []
synonym: "negative regulation of immune cell mediated cytotoxicity" EXACT []
synonym: "negative regulation of leucocyte mediated cytotoxicity" EXACT []
is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity
is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity
is_a: GO:0031342 ! negative regulation of cell killing
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001909 ! leukocyte mediated cytotoxicity
relationship: negatively_regulates GO:0001909 ! leukocyte mediated cytotoxicity

[Term]
id: GO:0001912
name: positive regulation of leukocyte mediated cytotoxicity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of leukocyte mediated cytotoxicity." [GOC:add, ISBN:0781735149, PMID:11911826]
synonym: "activation of leukocyte mediated cytotoxicity" NARROW []
synonym: "positive regulation of immune cell mediated cytotoxicity" EXACT []
synonym: "positive regulation of leucocyte mediated cytotoxicity" EXACT []
synonym: "stimulation of leukocyte mediated cytotoxicity" NARROW []
synonym: "up regulation of leukocyte mediated cytotoxicity" EXACT []
synonym: "up-regulation of leukocyte mediated cytotoxicity" EXACT []
synonym: "upregulation of leukocyte mediated cytotoxicity" EXACT []
is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity
is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity
is_a: GO:0031343 ! positive regulation of cell killing
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001909 ! leukocyte mediated cytotoxicity
relationship: positively_regulates GO:0001909 ! leukocyte mediated cytotoxicity

[Term]
id: GO:0001913
name: T cell mediated cytotoxicity
namespace: biological_process
def: "The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors." [GOC:add, GOC:pr, ISBN:0781735149, PMID:11911826]
comment: Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in the induction of apoptosis in the target cell. Note that both CD4 and CD8 positive T cells can mediate apoptosis of target cells, independently of their definition as 'helper' T cells or not.
synonym: "T cell mediated apoptosis" EXACT []
synonym: "T cell mediated cell death" EXACT []
synonym: "T cell mediated cell killing" EXACT []
synonym: "T cell mediated cytolysis" RELATED []
synonym: "T lymphocyte mediated cytotoxicity" EXACT []
synonym: "T-cell mediated apoptosis" EXACT []
synonym: "T-cell mediated cell death" EXACT []
synonym: "T-cell mediated cell killing" EXACT []
synonym: "T-cell mediated cytotoxicity" EXACT []
synonym: "T-lymphocyte mediated cytotoxicity" EXACT []
is_a: GO:0001909 ! leukocyte mediated cytotoxicity
is_a: GO:0002456 ! T cell mediated immunity
is_a: GO:0044699 ! single-organism process

[Term]
id: GO:0001914
name: regulation of T cell mediated cytotoxicity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity." [GOC:add, ISBN:0781735149]
synonym: "regulation of T cell mediated apoptosis" EXACT []
synonym: "regulation of T cell mediated cell death" EXACT []
synonym: "regulation of T cell mediated cell killing" EXACT []
synonym: "regulation of T cell mediated cytolysis" RELATED []
synonym: "regulation of T lymphocyte mediated cytotoxicity" EXACT []
synonym: "regulation of T-cell mediated apoptosis" EXACT []
synonym: "regulation of T-cell mediated cell death" EXACT []
synonym: "regulation of T-cell mediated cell killing" EXACT []
synonym: "regulation of T-cell mediated cytolysis" RELATED []
synonym: "regulation of T-cell mediated cytotoxicity" EXACT []
synonym: "regulation of T-lymphocyte mediated cytotoxicity" EXACT []
is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity
is_a: GO:0002709 ! regulation of T cell mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001913 ! T cell mediated cytotoxicity
relationship: regulates GO:0001913 ! T cell mediated cytotoxicity

[Term]
id: GO:0001915
name: negative regulation of T cell mediated cytotoxicity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of T cell mediated cytotoxicity." [GOC:add, ISBN:0781735149]
synonym: "down regulation of T cell mediated cytotoxicity" EXACT []
synonym: "down-regulation of T cell mediated cytotoxicity" EXACT []
synonym: "downregulation of T cell mediated cytotoxicity" EXACT []
synonym: "inhibition of T cell mediated cytotoxicity" NARROW []
synonym: "negative regulation of T cell mediated apoptosis" EXACT []
synonym: "negative regulation of T cell mediated cell death" EXACT []
synonym: "negative regulation of T cell mediated cell killing" EXACT []
synonym: "negative regulation of T cell mediated cytolysis" RELATED []
synonym: "negative regulation of T lymphocyte mediated cytotoxicity" EXACT []
synonym: "negative regulation of T-cell mediated apoptosis" EXACT []
synonym: "negative regulation of T-cell mediated cell death" EXACT []
synonym: "negative regulation of T-cell mediated cell killing" EXACT []
synonym: "negative regulation of T-cell mediated cytolysis" RELATED []
synonym: "negative regulation of T-cell mediated cytotoxicity" EXACT []
synonym: "negative regulation of T-lymphocyte mediated cytotoxicity" EXACT []
is_a: GO:0001911 ! negative regulation of leukocyte mediated cytotoxicity
is_a: GO:0001914 ! regulation of T cell mediated cytotoxicity
is_a: GO:0002710 ! negative regulation of T cell mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001913 ! T cell mediated cytotoxicity
relationship: negatively_regulates GO:0001913 ! T cell mediated cytotoxicity

[Term]
id: GO:0001916
name: positive regulation of T cell mediated cytotoxicity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity." [GOC:add, ISBN:0781735149]
synonym: "activation of T cell mediated cytotoxicity" NARROW []
synonym: "positive regulation of T cell mediated apoptosis" EXACT []
synonym: "positive regulation of T cell mediated cell death" EXACT []
synonym: "positive regulation of T cell mediated cell killing" EXACT []
synonym: "positive regulation of T cell mediated cytolysis" RELATED []
synonym: "positive regulation of T lymphocyte mediated cytotoxicity" EXACT []
synonym: "positive regulation of T-cell mediated apoptosis" EXACT []
synonym: "positive regulation of T-cell mediated cell death" EXACT []
synonym: "positive regulation of T-cell mediated cell killing" EXACT []
synonym: "positive regulation of T-cell mediated cytolysis" RELATED []
synonym: "positive regulation of T-cell mediated cytotoxicity" EXACT []
synonym: "positive regulation of T-lymphocyte mediated cytotoxicity" EXACT []
synonym: "stimulation of T cell mediated cytotoxicity" NARROW []
synonym: "up regulation of T cell mediated cytotoxicity" EXACT []
synonym: "up-regulation of T cell mediated cytotoxicity" EXACT []
synonym: "upregulation of T cell mediated cytotoxicity" EXACT []
is_a: GO:0001912 ! positive regulation of leukocyte mediated cytotoxicity
is_a: GO:0001914 ! regulation of T cell mediated cytotoxicity
is_a: GO:0002711 ! positive regulation of T cell mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001913 ! T cell mediated cytotoxicity
relationship: positively_regulates GO:0001913 ! T cell mediated cytotoxicity

[Term]
id: GO:0001917
name: photoreceptor inner segment
namespace: cellular_component
def: "The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs." [GOC:add, PMID:12019563]
subset: goslim_pir
is_a: GO:0097458 ! neuron part

[Term]
id: GO:0001918
name: farnesylated protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a farnesylated protein." [GOC:add, PMID:14555765]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0001919
name: regulation of receptor recycling
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of receptor recycling." [GOC:add]
is_a: GO:0023051 ! regulation of signaling
is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:0060255 ! regulation of macromolecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001881 ! receptor recycling
relationship: regulates GO:0001881 ! receptor recycling

[Term]
id: GO:0001920
name: negative regulation of receptor recycling
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of receptor recycling." [GOC:add]
synonym: "down regulation of receptor recycling" EXACT []
synonym: "down-regulation of receptor recycling" EXACT []
synonym: "downregulation of receptor recycling" EXACT []
synonym: "inhibition of receptor recycling" NARROW []
is_a: GO:0001919 ! regulation of receptor recycling
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0023057 ! negative regulation of signaling
is_a: GO:0031324 ! negative regulation of cellular metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001881 ! receptor recycling
relationship: negatively_regulates GO:0001881 ! receptor recycling

[Term]
id: GO:0001921
name: positive regulation of receptor recycling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of receptor recycling." [GOC:add]
synonym: "activation of receptor recycling" NARROW []
synonym: "stimulation of receptor recycling" NARROW []
synonym: "up regulation of receptor recycling" EXACT []
synonym: "up-regulation of receptor recycling" EXACT []
synonym: "upregulation of receptor recycling" EXACT []
is_a: GO:0001919 ! regulation of receptor recycling
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0023056 ! positive regulation of signaling
is_a: GO:0031325 ! positive regulation of cellular metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001881 ! receptor recycling
relationship: positively_regulates GO:0001881 ! receptor recycling

[Term]
id: GO:0001922
name: B-1 B cell homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of B cells of the B-1 subset such that the total number of B-1 B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity." [GOC:add, ISBN:0781735149]
comment: Note that this term represents the return of B-1 B cell levels to stable numbers following an immune response, as well as the proliferation and elimination of B-1 B cells in a organism required to maintain stable numbers in the absence of an outside stimulus.
synonym: "B-1 B lymphocyte homeostasis" EXACT []
synonym: "B-1 B-cell homeostasis" EXACT []
synonym: "B-1 B-lymphocyte homeostasis" EXACT []
is_a: GO:0001782 ! B cell homeostasis

[Term]
id: GO:0001923
name: B-1 B cell differentiation
namespace: biological_process
def: "The process in which a hemopoietic stem cell acquires the specialized features of a B-1 B cell. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity." [GOC:add, ISBN:0781735149]
synonym: "B-1 B cell development" RELATED [GOC:add]
synonym: "B-1 B lymphocyte differentiation" EXACT []
synonym: "B-1 B-cell differentiation" EXACT []
synonym: "B-1 B-lymphocyte differentiation" EXACT []
is_a: GO:0002335 ! mature B cell differentiation

[Term]
id: GO:0001924
name: regulation of B-1 B cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of B-1 B cell differentiation. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "regulation of B-1 B cell development" RELATED [GOC:add]
synonym: "regulation of B-1 B lymphocyte differentiation" EXACT []
synonym: "regulation of B-1 B-cell differentiation" EXACT []
synonym: "regulation of B-1 B-lymphocyte differentiation" EXACT []
is_a: GO:0045577 ! regulation of B cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001923 ! B-1 B cell differentiation
relationship: regulates GO:0001923 ! B-1 B cell differentiation

[Term]
id: GO:0001925
name: negative regulation of B-1 B cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of B-1 B cell differentiation." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "down regulation of B-1 B cell differentiation" EXACT []
synonym: "down-regulation of B-1 B cell differentiation" EXACT []
synonym: "downregulation of B-1 B cell differentiation" EXACT []
synonym: "inhibition of B-1 B cell differentiation" NARROW []
synonym: "negative regulation of B-1 B cell development" RELATED [GOC:add]
synonym: "negative regulation of B-1 B lymphocyte differentiation" EXACT []
synonym: "negative regulation of B-1 B-cell differentiation" EXACT []
synonym: "negative regulation of B-1 B-lymphocyte differentiation" EXACT []
is_a: GO:0001924 ! regulation of B-1 B cell differentiation
is_a: GO:0045578 ! negative regulation of B cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001923 ! B-1 B cell differentiation
relationship: negatively_regulates GO:0001923 ! B-1 B cell differentiation

[Term]
id: GO:0001926
name: positive regulation of B-1 B cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of B-1 B cell differentiation." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "activation of B-1 B cell differentiation" NARROW []
synonym: "positive regulation of B-1 B cell development" RELATED [GOC:add]
synonym: "positive regulation of B-1 B lymphocyte differentiation" EXACT []
synonym: "positive regulation of B-1 B-cell differentiation" EXACT []
synonym: "positive regulation of B-1 B-lymphocyte differentiation" EXACT []
synonym: "stimulation of B-1 B cell differentiation" NARROW []
synonym: "up regulation of B-1 B cell differentiation" EXACT []
synonym: "up-regulation of B-1 B cell differentiation" EXACT []
synonym: "upregulation of B-1 B cell differentiation" EXACT []
is_a: GO:0001924 ! regulation of B-1 B cell differentiation
is_a: GO:0045579 ! positive regulation of B cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001923 ! B-1 B cell differentiation
relationship: positively_regulates GO:0001923 ! B-1 B cell differentiation

[Term]
id: GO:0001927
name: exocyst assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of various polypeptides into the exocyst complex." [GOC:hjd, PMID:9700152, Wikipedia:Exocyst]
is_a: GO:0043623 ! cellular protein complex assembly
relationship: part_of GO:0006904 ! vesicle docking involved in exocytosis

[Term]
id: GO:0001928
name: regulation of exocyst assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of exocyst assembly." [GOC:hjd]
comment: Note that the assembly is regulated by several small GTPases of the Rab and Rho families.
is_a: GO:0017157 ! regulation of exocytosis
is_a: GO:0043254 ! regulation of protein complex assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001927 ! exocyst assembly
relationship: regulates GO:0001927 ! exocyst assembly

[Term]
id: GO:0001929
name: negative regulation of exocyst assembly
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate or extent of exocyst assembly." [GOC:hjd]
synonym: "down regulation of exocyst assembly" EXACT []
synonym: "down-regulation of exocyst assembly" EXACT []
synonym: "downregulation of exocyst assembly" EXACT []
synonym: "inhibition of exocyst assembly" NARROW []
is_a: GO:0001928 ! regulation of exocyst assembly
is_a: GO:0031333 ! negative regulation of protein complex assembly
is_a: GO:0045920 ! negative regulation of exocytosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001927 ! exocyst assembly
relationship: negatively_regulates GO:0001927 ! exocyst assembly

[Term]
id: GO:0001930
name: positive regulation of exocyst assembly
namespace: biological_process
def: "Any process that increases the rate or extent of exocyst assembly." [GOC:hjd]
synonym: "activation of exocyst assembly" NARROW []
synonym: "stimulation of exocyst assembly" NARROW []
synonym: "up regulation of exocyst assembly" EXACT []
synonym: "up-regulation of exocyst assembly" EXACT []
synonym: "upregulation of exocyst assembly" EXACT []
is_a: GO:0001928 ! regulation of exocyst assembly
is_a: GO:0031334 ! positive regulation of protein complex assembly
is_a: GO:0045921 ! positive regulation of exocytosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001927 ! exocyst assembly
relationship: positively_regulates GO:0001927 ! exocyst assembly

[Term]
id: GO:0001931
name: uropod
namespace: cellular_component
def: "A membrane projection with related cytoskeletal components at the trailing edge of a cell in the process of migrating or being activated, found on the opposite side of the cell from the leading edge or immunological synapse, respectively." [GOC:add, ISBN:0781735149, PMID:12714569, PMID:12787750]
synonym: "distal pole complex" RELATED []
synonym: "retractile pole" RELATED []
synonym: "uropodium" EXACT []
is_a: GO:0042995 ! cell projection
intersection_of: GO:0042995 ! cell projection
intersection_of: part_of GO:0031254 ! cell trailing edge
relationship: part_of GO:0031254 ! cell trailing edge

[Term]
id: GO:0001932
name: regulation of protein phosphorylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein." [GOC:hjd]
subset: gosubset_prok
synonym: "regulation of protein amino acid phosphorylation" EXACT [GOC:bf]
is_a: GO:0031399 ! regulation of protein modification process
is_a: GO:0042325 ! regulation of phosphorylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006468 ! protein phosphorylation
relationship: regulates GO:0006468 ! protein phosphorylation

[Term]
id: GO:0001933
name: negative regulation of protein phosphorylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein." [GOC:hjd]
subset: gosubset_prok
synonym: "down regulation of protein amino acid phosphorylation" EXACT []
synonym: "down-regulation of protein amino acid phosphorylation" EXACT []
synonym: "downregulation of protein amino acid phosphorylation" EXACT []
synonym: "inhibition of protein amino acid phosphorylation" NARROW []
synonym: "negative regulation of protein amino acid phosphorylation" EXACT [GOC:bf]
is_a: GO:0001932 ! regulation of protein phosphorylation
is_a: GO:0031400 ! negative regulation of protein modification process
is_a: GO:0042326 ! negative regulation of phosphorylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006468 ! protein phosphorylation
relationship: negatively_regulates GO:0006468 ! protein phosphorylation

[Term]
id: GO:0001934
name: positive regulation of protein phosphorylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd]
subset: gosubset_prok
synonym: "activation of protein amino acid phosphorylation" NARROW []
synonym: "positive regulation of protein amino acid phosphorylation" EXACT [GOC:bf]
synonym: "stimulation of protein amino acid phosphorylation" NARROW []
synonym: "up regulation of protein amino acid phosphorylation" EXACT []
synonym: "up-regulation of protein amino acid phosphorylation" EXACT []
synonym: "upregulation of protein amino acid phosphorylation" EXACT []
is_a: GO:0001932 ! regulation of protein phosphorylation
is_a: GO:0031401 ! positive regulation of protein modification process
is_a: GO:0042327 ! positive regulation of phosphorylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006468 ! protein phosphorylation
relationship: positively_regulates GO:0006468 ! protein phosphorylation

[Term]
id: GO:0001935
name: endothelial cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium." [GOC:add, ISBN:0781735149]
is_a: GO:0050673 ! epithelial cell proliferation

[Term]
id: GO:0001936
name: regulation of endothelial cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of endothelial cell proliferation." [GOC:add]
is_a: GO:0050678 ! regulation of epithelial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001935 ! endothelial cell proliferation
relationship: regulates GO:0001935 ! endothelial cell proliferation

[Term]
id: GO:0001937
name: negative regulation of endothelial cell proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation." [GOC:add]
synonym: "down regulation of endothelial cell proliferation" EXACT []
synonym: "down-regulation of endothelial cell proliferation" EXACT []
synonym: "downregulation of endothelial cell proliferation" EXACT []
synonym: "inhibition of endothelial cell proliferation" NARROW []
is_a: GO:0001936 ! regulation of endothelial cell proliferation
is_a: GO:0050680 ! negative regulation of epithelial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001935 ! endothelial cell proliferation
relationship: negatively_regulates GO:0001935 ! endothelial cell proliferation

[Term]
id: GO:0001938
name: positive regulation of endothelial cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of endothelial cell proliferation." [GOC:add]
synonym: "activation of endothelial cell proliferation" NARROW []
synonym: "stimulation of endothelial cell proliferation" NARROW []
synonym: "up regulation of endothelial cell proliferation" EXACT []
synonym: "up-regulation of endothelial cell proliferation" EXACT []
synonym: "upregulation of endothelial cell proliferation" EXACT []
is_a: GO:0001936 ! regulation of endothelial cell proliferation
is_a: GO:0050679 ! positive regulation of epithelial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001935 ! endothelial cell proliferation
relationship: positively_regulates GO:0001935 ! endothelial cell proliferation

[Term]
id: GO:0001939
name: female pronucleus
namespace: cellular_component
def: "The pronucleus originating from the ovum that is being fertilized." [GOC:hjd, ISBN:0198506732]
is_a: GO:0045120 ! pronucleus

[Term]
id: GO:0001940
name: male pronucleus
namespace: cellular_component
def: "The pronucleus originating from the spermatozoa that was involved in fertilization." [GOC:hjd, ISBN:0198506732]
is_a: GO:0045120 ! pronucleus

[Term]
id: GO:0001941
name: postsynaptic membrane organization
namespace: biological_process
def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic membrane, the specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft)." [GOC:dph, GOC:pr]
synonym: "post-synaptic membrane organization" EXACT []
synonym: "postsynaptic membrane organisation" EXACT [GOC:curators]
is_a: GO:0044802 ! single-organism membrane organization
relationship: part_of GO:0050808 ! synapse organization

[Term]
id: GO:0001942
name: hair follicle development
namespace: biological_process
alt_id: GO:0001943
def: "The process whose specific outcome is the progression of the hair follicle over time, from its formation to the mature structure. A hair follicle is a tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open." [GOC:dph, UBERON:0002073]
is_a: GO:0022405 ! hair cycle process
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0098773 ! skin epidermis development

[Term]
id: GO:0001944
name: vasculature development
namespace: biological_process
def: "The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism." [GOC:dph, UBERON:0002409]
synonym: "vascular system development" RELATED [GOC:curators]
is_a: GO:0048731 ! system development
relationship: part_of GO:0072358 ! cardiovascular system development

[Term]
id: GO:0001945
name: lymph vessel development
namespace: biological_process
def: "The process whose specific outcome is the progression of a lymph vessel over time, from its formation to the mature structure." [GOC:dph, UBERON:0001473]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0001944 ! vasculature development

[Term]
id: GO:0001946
name: lymphangiogenesis
namespace: biological_process
def: "Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels." [GOC:dph, PMID:11596157]
synonym: "lymph vessel formation" EXACT systematic_synonym []
xref: Wikipedia:Lymphangiogenesis
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0036303 ! lymph vessel morphogenesis

[Term]
id: GO:0001947
name: heart looping
namespace: biological_process
def: "The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceeding septation." [GOC:dph, PMID:12094232]
synonym: "cardiac looping" EXACT []
is_a: GO:0003143 ! embryonic heart tube morphogenesis
relationship: part_of GO:0061371 ! determination of heart left/right asymmetry

[Term]
id: GO:0001948
name: glycoprotein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a glycoprotein, a protein that contains covalently bound glycose (monosaccharide) residues. These also include proteoglycans." [GOC:hjd, ISBN:0198506732]
is_a: GO:0005515 ! protein binding
is_a: GO:0097367 ! carbohydrate derivative binding

[Term]
id: GO:0001949
name: sebaceous gland cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized epidermal cell acquires the specialized features of a sebaceous gland cell." [GOC:mgi_curators, PMID:15737203]
synonym: "sebocytes differentiation" NARROW [GOC:mgi_curators]
is_a: GO:0009913 ! epidermal cell differentiation
relationship: part_of GO:0048733 ! sebaceous gland development

[Term]
id: GO:0001950
name: obsolete plasma membrane enriched fraction
namespace: cellular_component
def: "OBSOLETE: The fraction of cells, prepared by disruptive biochemical methods, that is enriched for plasma membranes." [GOC:mgi_curators, PMID:11562363, PMID:15601832]
comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component.
synonym: "plasma membrane enriched fraction" EXACT []
synonym: "PME fraction" RELATED [GOC:mah]
is_obsolete: true
consider: GO:0005886

[Term]
id: GO:0001951
name: intestinal D-glucose absorption
namespace: biological_process
def: "Uptake of D-glucose into the blood by absorption from the small intestine." [GOC:mgi_curators, PMID:5601832]
is_a: GO:0015758 ! glucose transport
is_a: GO:0050892 ! intestinal absorption

[Term]
id: GO:0001952
name: regulation of cell-matrix adhesion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix." [GOC:hjd]
is_a: GO:0010810 ! regulation of cell-substrate adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007160 ! cell-matrix adhesion
relationship: regulates GO:0007160 ! cell-matrix adhesion

[Term]
id: GO:0001953
name: negative regulation of cell-matrix adhesion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate or extent of cell adhesion to the extracellular matrix." [GOC:hjd]
synonym: "down regulation of cell-matrix adhesion" EXACT []
synonym: "down-regulation of cell-matrix adhesion" EXACT []
synonym: "downregulation of cell-matrix adhesion" EXACT []
synonym: "inhibition of cell-matrix adhesion" NARROW []
is_a: GO:0001952 ! regulation of cell-matrix adhesion
is_a: GO:0010812 ! negative regulation of cell-substrate adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007160 ! cell-matrix adhesion
relationship: negatively_regulates GO:0007160 ! cell-matrix adhesion

[Term]
id: GO:0001954
name: positive regulation of cell-matrix adhesion
namespace: biological_process
def: "Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix." [GOC:hjd]
synonym: "activation of cell-matrix adhesion" NARROW []
synonym: "stimulation of cell-matrix adhesion" NARROW []
synonym: "up regulation of cell-matrix adhesion" EXACT []
synonym: "up-regulation of cell-matrix adhesion" EXACT []
synonym: "upregulation of cell-matrix adhesion" EXACT []
is_a: GO:0001952 ! regulation of cell-matrix adhesion
is_a: GO:0010811 ! positive regulation of cell-substrate adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007160 ! cell-matrix adhesion
relationship: positively_regulates GO:0007160 ! cell-matrix adhesion

[Term]
id: GO:0001955
name: blood vessel maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state." [GOC:dph]
is_a: GO:0071695 ! anatomical structure maturation
relationship: part_of GO:0001568 ! blood vessel development

[Term]
id: GO:0001956
name: positive regulation of neurotransmitter secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter." [GOC:hjd]
synonym: "activation of neurotransmitter secretion" NARROW []
synonym: "stimulation of neurotransmitter secretion" NARROW []
synonym: "up regulation of neurotransmitter secretion" EXACT []
synonym: "up-regulation of neurotransmitter secretion" EXACT []
synonym: "upregulation of neurotransmitter secretion" EXACT []
is_a: GO:0046928 ! regulation of neurotransmitter secretion
is_a: GO:0050806 ! positive regulation of synaptic transmission
is_a: GO:0051590 ! positive regulation of neurotransmitter transport
is_a: GO:1903532 ! positive regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007269 ! neurotransmitter secretion
relationship: positively_regulates GO:0007269 ! neurotransmitter secretion

[Term]
id: GO:0001957
name: intramembranous ossification
namespace: biological_process
def: "Direct ossification that occurs within mesenchyme or an accumulation of relatively unspecialized cells." [ISBN:0878932437]
comment: An instance of intramembranous ossification may also be classified as metaplastic; the former classifies based on tissue type location, and the latter based on mechanism/cell division.
synonym: "dermal ossification" NARROW [GO_REF:0000034]
synonym: "intramembranous bone ossification" RELATED [GOC:cjm]
xref: Wikipedia:Intramembranous_ossification
is_a: GO:0036072 ! direct ossification

[Term]
id: GO:0001958
name: endochondral ossification
namespace: biological_process
def: "Replacement ossification wherein bone tissue replaces cartilage." [GO_REF:0000034, ISBN:0878932437]
xref: Wikipedia:Endochondral_ossification
is_a: GO:0036075 ! replacement ossification
relationship: part_of GO:0060350 ! endochondral bone morphogenesis

[Term]
id: GO:0001959
name: regulation of cytokine-mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the cytokine mediated signaling pathway." [GOC:hjd]
synonym: "regulation of cytokine and chemokine mediated signaling pathway" EXACT []
synonym: "regulation of cytokine mediated signaling pathway" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of cytokine mediated signalling pathway" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0060759 ! regulation of response to cytokine stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019221 ! cytokine-mediated signaling pathway
relationship: regulates GO:0019221 ! cytokine-mediated signaling pathway

[Term]
id: GO:0001960
name: negative regulation of cytokine-mediated signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the cytokine mediated signaling pathway." [GOC:hjd]
synonym: "down regulation of cytokine mediated signaling pathway" EXACT []
synonym: "down-regulation of cytokine mediated signaling pathway" EXACT []
synonym: "downregulation of cytokine mediated signaling pathway" EXACT []
synonym: "inhibition of cytokine mediated signaling pathway" NARROW []
synonym: "negative regulation of cytokine and chemokine mediated signaling pathway" EXACT []
synonym: "negative regulation of cytokine mediated signaling pathway" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of cytokine mediated signalling pathway" EXACT []
is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0060761 ! negative regulation of response to cytokine stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019221 ! cytokine-mediated signaling pathway
relationship: negatively_regulates GO:0019221 ! cytokine-mediated signaling pathway

[Term]
id: GO:0001961
name: positive regulation of cytokine-mediated signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a cytokine mediated signaling pathway." [GOC:hjd]
synonym: "activation of cytokine mediated signaling pathway" NARROW []
synonym: "positive regulation of cytokine and chemokine mediated signaling pathway" EXACT []
synonym: "positive regulation of cytokine mediated signaling pathway" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of cytokine mediated signalling pathway" EXACT []
synonym: "stimulation of cytokine mediated signaling pathway" NARROW []
synonym: "up regulation of cytokine mediated signaling pathway" EXACT []
synonym: "up-regulation of cytokine mediated signaling pathway" EXACT []
synonym: "upregulation of cytokine mediated signaling pathway" EXACT []
is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0060760 ! positive regulation of response to cytokine stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0019221 ! cytokine-mediated signaling pathway
relationship: positively_regulates GO:0019221 ! cytokine-mediated signaling pathway

[Term]
id: GO:0001962
name: alpha-1,3-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a galactose residue from a donor molecule, such as GDP-galactose or UDP-galactose, to an oligosaccharide, forming an alpha-(1->3) linkage." [GOC:hjd, PMID:10854427]
synonym: "isoglobotriaosylceramide synthase" NARROW []
xref: EC:2.4.1.-
is_a: GO:0008378 ! galactosyltransferase activity

[Term]
id: GO:0001963
name: synaptic transmission, dopaminergic
namespace: biological_process
def: "The process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine." [GOC:dph]
is_a: GO:0007270 ! neuron-neuron synaptic transmission

[Term]
id: GO:0001964
name: startle response
namespace: biological_process
def: "An action or movement due to the application of a sudden unexpected stimulus." [GOC:dph]
xref: Wikipedia:Startle_reaction
is_a: GO:0009605 ! response to external stimulus
is_a: GO:0050905 ! neuromuscular process

[Term]
id: GO:0001965
name: G-protein alpha-subunit binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide." [GOC:hjd]
synonym: "G-alpha protein subunit binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0001966
name: thigmotaxis
namespace: biological_process
def: "The directed movement of a motile cell or organism in response to touch." [GOC:dph]
synonym: "stereotaxis" EXACT []
synonym: "taxis in response to mechanical stimulus" BROAD []
synonym: "taxis in response to touch stimulus" EXACT []
is_a: GO:0042330 ! taxis

[Term]
id: GO:0001967
name: suckling behavior
namespace: biological_process
def: "Specific behavior of a newborn or infant mammal that results in the derivation of nourishment from the breast." [GOC:dph, GOC:pr]
synonym: "nursing behavior" EXACT []
is_a: GO:0007631 ! feeding behavior
is_a: GO:0051705 ! multi-organism behavior

[Term]
id: GO:0001968
name: fibronectin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids." [GOC:hjd]
subset: goslim_chembl
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0001969
name: regulation of activation of membrane attack complex
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade." [GOC:hjd]
synonym: "regulation of activation of MAC" EXACT [GOC:mah]
synonym: "regulation of activation of TCC" NARROW [GOC:mah]
synonym: "regulation of activation of terminal complement complex" NARROW [GOC:add]
synonym: "regulation of activation of the terminal complement cascade" NARROW [GOC:mah]
synonym: "regulation of MAC assembly" EXACT [GOC:rl]
synonym: "regulation of MAC formation" EXACT [GOC:rl]
synonym: "regulation of membrane attack complex assembly" EXACT [GOC:rl]
synonym: "regulation of membrane attack complex formation" EXACT [GOC:rl]
is_a: GO:0030449 ! regulation of complement activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001905 ! activation of membrane attack complex
relationship: regulates GO:0001905 ! activation of membrane attack complex

[Term]
id: GO:0001970
name: positive regulation of activation of membrane attack complex
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade." [GOC:hjd]
synonym: "activation of activation of membrane attack complex" NARROW []
synonym: "positive regulation of activation of MAC" EXACT [GOC:mah]
synonym: "positive regulation of activation of TCC" NARROW [GOC:mah]
synonym: "positive regulation of activation of terminal complement complex" NARROW [GOC:add]
synonym: "positive regulation of activation of the terminal complement cascade" NARROW [GOC:mah]
synonym: "positive regulation of MAC assembly" EXACT [GOC:rl]
synonym: "positive regulation of MAC formation" EXACT [GOC:rl]
synonym: "positive regulation of membrane attack complex assembly" EXACT [GOC:rl]
synonym: "positive regulation of membrane attack complex formation" EXACT [GOC:rl]
synonym: "stimulation of activation of membrane attack complex" NARROW []
synonym: "up regulation of activation of membrane attack complex" EXACT []
synonym: "up-regulation of activation of membrane attack complex" EXACT []
synonym: "upregulation of activation of membrane attack complex" EXACT []
is_a: GO:0001969 ! regulation of activation of membrane attack complex
is_a: GO:0045917 ! positive regulation of complement activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001905 ! activation of membrane attack complex
relationship: positively_regulates GO:0001905 ! activation of membrane attack complex

[Term]
id: GO:0001971
name: negative regulation of activation of membrane attack complex
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade." [GOC:hjd]
synonym: "down regulation of activation of membrane attack complex" EXACT []
synonym: "down-regulation of activation of membrane attack complex" EXACT []
synonym: "downregulation of activation of membrane attack complex" EXACT []
synonym: "inhibition of activation of membrane attack complex" NARROW []
synonym: "negative regulation of activation of MAC" EXACT [GOC:mah]
synonym: "negative regulation of activation of TCC" NARROW [GOC:mah]
synonym: "negative regulation of activation of terminal complement complex" NARROW [GOC:add]
synonym: "negative regulation of activation of the terminal complement cascade" NARROW [GOC:mah]
synonym: "negative regulation of MAC assembly" EXACT [GOC:rl]
synonym: "negative regulation of MAC formation" EXACT [GOC:rl]
synonym: "negative regulation of membrane attack complex assembly" EXACT [GOC:rl]
synonym: "negative regulation of membrane attack complex formation" EXACT [GOC:rl]
is_a: GO:0001969 ! regulation of activation of membrane attack complex
is_a: GO:0045916 ! negative regulation of complement activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001905 ! activation of membrane attack complex
relationship: negatively_regulates GO:0001905 ! activation of membrane attack complex

[Term]
id: GO:0001972
name: retinoic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with retinoic acid, 3,7-dimethyl-9-(2,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid." [GOC:hjd]
is_a: GO:0005501 ! retinoid binding
is_a: GO:0033293 ! monocarboxylic acid binding

[Term]
id: GO:0001973
name: adenosine receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a receptor binding to extracellular adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity." [GOC:dph]
synonym: "adenosine receptor signaling pathway, G-protein coupled" EXACT [PMID:9755289]
synonym: "adenosine receptor signalling pathway" EXACT [GOC:mah]
synonym: "P1 receptor signaling pathway" EXACT [PMID:9755289]
is_a: GO:0035588 ! G-protein coupled purinergic receptor signaling pathway

[Term]
id: GO:0001974
name: blood vessel remodeling
namespace: biological_process
def: "The reorganization or renovation of existing blood vessels." [GOC:hjd]
is_a: GO:0048771 ! tissue remodeling

[Term]
id: GO:0001975
name: response to amphetamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine." [CHEBI:2679, GOC:dph, GOC:ef]
is_a: GO:0014075 ! response to amine

[Term]
id: GO:0001976
name: neurological system process involved in regulation of systemic arterial blood pressure
namespace: biological_process
def: "The regulation of blood pressure mediated by detection of stimuli and a neurological response." [GOC:mtg_cardio, ISBN:0721643949]
synonym: "blood pressure regulation by neurological process" EXACT []
synonym: "fast control of arterial pressure" RELATED []
synonym: "neurological process involved in regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb]
is_a: GO:0050877 ! neurological system process
intersection_of: GO:0050877 ! neurological system process
intersection_of: part_of GO:0003073 ! regulation of systemic arterial blood pressure
relationship: part_of GO:0003073 ! regulation of systemic arterial blood pressure

[Term]
id: GO:0001977
name: renal system process involved in regulation of blood volume
namespace: biological_process
def: "A slow mechanism of blood pressure regulation that responds to changes in pressure resulting from fluid and salt intake by modulating the quantity of blood in the circulatory system." [GOC:dph, GOC:tb, ISBN:0721643949]
synonym: "renal blood volume control of blood pressure" RELATED []
synonym: "renal regulation of blood volume" RELATED [GOC:dph, GOC:tb]
is_a: GO:0003071 ! renal system process involved in regulation of systemic arterial blood pressure
relationship: part_of GO:0050878 ! regulation of body fluid levels

[Term]
id: GO:0001978
name: regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback
namespace: biological_process
def: "The process that modulates blood pressure by sensing the amount of stretch occurring in large arteries and responding to the input via central nervous system control." [GOC:dph, GOC:tb, ISBN:0721643949]
synonym: "baroreceptor feedback control of blood pressure" RELATED []
synonym: "baroreceptor pressure buffer system" RELATED [ISBN:068340007X]
synonym: "carotid sinus baroreceptor feedback regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb]
is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure
relationship: part_of GO:0003025 ! regulation of systemic arterial blood pressure by baroreceptor feedback

[Term]
id: GO:0001979
name: regulation of systemic arterial blood pressure by chemoreceptor signaling
namespace: biological_process
def: "The process that modulates blood pressure by the action of chemoreceptors found in the carotid and aortic bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions." [GOC:dph, GOC:tb, ISBN:0721643949]
synonym: "chemoreceptor control of blood pressure" RELATED []
synonym: "chemoreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of systemic arterial blood pressure by chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure

[Term]
id: GO:0001980
name: regulation of systemic arterial blood pressure by ischemic conditions
namespace: biological_process
def: "The process that modulates blood pressure by the detection of carbon dioxide levels in the brain stem. Increased levels activate the sympathetic vasoconstrictor mechanism increasing the force with which blood flows through the circulatory system." [GOC:dph, GOC:tb, ISBN:0721643949]
synonym: "CNS ischemic response" RELATED [ISBN:0721643949]
synonym: "ischemic control of blood pressure" RELATED []
synonym: "ischemic regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb]
is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure

[Term]
id: GO:0001981
name: baroreceptor detection of arterial stretch
namespace: biological_process
def: "The series of events by which the change in diameter of an artery is detected and converted to a molecular signal." [GOC:mtg_cardio, ISBN:0721643949]
is_a: GO:0003018 ! vascular process in circulatory system
is_a: GO:0050982 ! detection of mechanical stimulus
relationship: part_of GO:0001978 ! regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback

[Term]
id: GO:0001982
name: baroreceptor response to decreased systemic arterial blood pressure
namespace: biological_process
def: "The lowering of the number of nerve impulses from baroreceptors as a result of decreased stretch of an artery that results in an increased in sympathetic nerve impulses to peripheral blood vessels." [GOC:dph, GOC:mtg_cardio, ISBN:0323031951, ISBN:0721643949]
is_a: GO:0001978 ! regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback
is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure

[Term]
id: GO:0001983
name: baroreceptor response to increased systemic arterial blood pressure
namespace: biological_process
def: "The increase in nerve impulses from baroreceptors as a result of increased pressure on an artery that results in an inhibition of sympathetic nerve impulses to peripheral blood vessels." [GOC:mtg_cardio, ISBN:0323031951, ISBN:0721643949]
is_a: GO:0001978 ! regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback
is_a: GO:0003085 ! negative regulation of systemic arterial blood pressure

[Term]
id: GO:0001984
name: vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure
namespace: biological_process
def: "An increase in the internal diameter of an artery, triggered by vasomotor suppression, during the chemoreceptor response to decreased blood pressure." [ISBN:0721643949]
is_a: GO:0042311 ! vasodilation
relationship: part_of GO:0001983 ! baroreceptor response to increased systemic arterial blood pressure

[Term]
id: GO:0001985
name: negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction as a result of the baroreceptor response to increased blood pressure." [ISBN:0721643949]
synonym: "down regulation of heart contraction rate in baroreceptor response to increased blood pressure" EXACT []
synonym: "down-regulation of heart contraction rate in baroreceptor response to increased blood pressure" EXACT []
synonym: "downregulation of heart contraction rate in baroreceptor response to increased blood pressure" EXACT []
synonym: "inhibition of heart contraction rate in baroreceptor response to increased blood pressure" NARROW []
synonym: "negative control of heart contraction rate in baroreceptor response to increased blood pressure" EXACT []
synonym: "negative regulation of cardiac contraction rate in baroreceptor response to increased blood pressure" RELATED []
synonym: "negative regulation of heart contraction rate in baroreceptor response to increased blood pressure" EXACT []
is_a: GO:0010459 ! negative regulation of heart rate
intersection_of: GO:0010459 ! negative regulation of heart rate
intersection_of: part_of GO:0001983 ! baroreceptor response to increased systemic arterial blood pressure
relationship: part_of GO:0001983 ! baroreceptor response to increased systemic arterial blood pressure

[Term]
id: GO:0001986
name: negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure
namespace: biological_process
def: "Any process that decreases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the baroreceptor response to increased blood pressure." [GOC:mtg_cardio, ISBN:0721643949]
synonym: "decreased force of heart contraction during baroreceptor response to increased systemic arterial blood pressure" EXACT []
synonym: "decreased strength of cardiac contraction during baroreceptor response to increased blood pressure" EXACT []
is_a: GO:0045822 ! negative regulation of heart contraction
relationship: part_of GO:0001983 ! baroreceptor response to increased systemic arterial blood pressure

[Term]
id: GO:0001987
name: vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure
namespace: biological_process
def: "A process that is triggered by vasomotor excitation and results in a decrease in the diameter of an artery during the baroreceptor response to decreased blood pressure." [ISBN:0721643949]
is_a: GO:0042310 ! vasoconstriction
relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure

[Term]
id: GO:0001988
name: positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of heart contraction as a result of the baroreceptor response to decreased blood pressure." [ISBN:0721643949]
synonym: "activation of heart contraction rate in baroreceptor response to decreased blood pressure" NARROW []
synonym: "positive control of heart contraction rate in baroreceptor response to decreased blood pressure" EXACT []
synonym: "positive regulation of cardiac contraction rate in baroreceptor response to decreased blood pressure" EXACT []
synonym: "positive regulation of heart contraction rate in baroreceptor response to decreased blood pressure" RELATED []
synonym: "stimulation of heart contraction rate in baroreceptor response to decreased blood pressure" NARROW []
synonym: "up regulation of heart contraction rate in baroreceptor response to decreased blood pressure" EXACT []
synonym: "up-regulation of heart contraction rate in baroreceptor response to decreased blood pressure" EXACT []
synonym: "upregulation of heart contraction rate in baroreceptor response to decreased blood pressure" EXACT []
is_a: GO:0010460 ! positive regulation of heart rate
intersection_of: GO:0010460 ! positive regulation of heart rate
intersection_of: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure
relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure

[Term]
id: GO:0001989
name: positive regulation of the force of heart contraction involved in baroreceptor response to decreased systemic arterial blood pressure
namespace: biological_process
def: "Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as part of the baroreceptor response to decreased blood pressure." [ISBN:0721643949]
synonym: "increased force of heart contraction during baroreceptor response to decreased systemic arterial blood pressure" RELATED []
synonym: "increased strength of cardiac contraction during baroreceptor response to decreased blood pressure" RELATED []
synonym: "positive regulation of the force of heart contraction during baroreceptor response to decreased systemic arterial blood pressure" RELATED [GOC:tb]
is_a: GO:0045823 ! positive regulation of heart contraction
relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure

[Term]
id: GO:0001990
name: regulation of systemic arterial blood pressure by hormone
namespace: biological_process
def: "The process in which hormones modulate the force with which blood passes through the circulatory system. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." [GOC:mtg_cardio, ISBN:0721643949]
synonym: "blood pressure regulation by hormone" EXACT []
synonym: "hormonal control of blood pressure" RELATED []
synonym: "hormonal regulation of blood pressure" EXACT []
is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal
is_a: GO:0050886 ! endocrine process

[Term]
id: GO:0001991
name: regulation of systemic arterial blood pressure by circulatory renin-angiotensin
namespace: biological_process
def: "The process in which angiotensinogen metabolites in the bloodstream modulate the force with which blood passes through the circulatory system. The process begins when renin is released and cleaves angiotensinogen." [ISBN:0721643949]
synonym: "circulatory renin-angiotensin blood pressure regulation" EXACT []
synonym: "circulatory renin-angiotensin control of blood pressure" RELATED []
synonym: "circulatory renin-angiotensin regulation of blood pressure" EXACT []
synonym: "control of blood pressure by circulatory renin-angiotensin" RELATED []
synonym: "renin-angiotensin blood pressure control" RELATED []
is_a: GO:0003081 ! regulation of systemic arterial blood pressure by renin-angiotensin

[Term]
id: GO:0001992
name: regulation of systemic arterial blood pressure by vasopressin
namespace: biological_process
def: "The regulation of blood pressure mediated by the signaling molecule vasopressin. Vasopressin is produced in the hypothalamus, and affects vasoconstriction, and renal water transport." [GOC:mtg_cardio, ISBN:0721643949]
synonym: "blood pressure regulation by vasopressin" EXACT []
synonym: "vasopressin control of blood pressure" RELATED []
is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone

[Term]
id: GO:0001993
name: regulation of systemic arterial blood pressure by norepinephrine-epinephrine
namespace: biological_process
def: "The process in which the secretion of norepinephrine or epinephrine into the bloodstream modulates the force with which blood passes through the circulatory system." [ISBN:0721643949]
synonym: "noradrenaline-adrenaline regulation of blood pressure" RELATED []
synonym: "norepinephrine-epinephrine blood pressure control" RELATED []
synonym: "norepinephrine-epinephrine blood pressure regulation" EXACT []
is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal

[Term]
id: GO:0001994
name: norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
namespace: biological_process
def: "A process that results in a decrease in the diameter of an artery during the norepinephrine-epinephrine response to decreased blood pressure." [GOC:mtg_cardio, ISBN:0721643949]
synonym: "noradrenaline-adrenaline vasoconstriction involved in regulation of blood pressure" EXACT []
synonym: "norepinephrine-epinephrine vasoconstriction during blood pressure control" RELATED []
synonym: "norepinephrine-epinephrine vasoconstriction during blood pressure regulation" EXACT []
synonym: "norepinephrine-epinephrine vasoconstriction during control of blood pressure" RELATED []
is_a: GO:0042310 ! vasoconstriction
relationship: part_of GO:0003321 ! positive regulation of blood pressure by epinephrine-norepinephrine

[Term]
id: GO:0001995
name: norepinephrine-epinephrine catabolic process in blood stream
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of norepinephrine or epinephrine in the bloodstream." [GOC:hjd]
synonym: "noradrenaline-adrenalin catabolic process in blood stream" EXACT []
is_a: GO:0042419 ! epinephrine catabolic process
relationship: part_of GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine

[Term]
id: GO:0001996
name: positive regulation of heart rate by epinephrine-norepinephrine
namespace: biological_process
def: "The process in which the presence of epinephrine or norepinephrine in the bloodstream activates, maintains or increases the rate of heart contraction." [GOC:dph]
synonym: "activation of heart contraction rate by epinephrine-norepinephrine" NARROW []
synonym: "increased chronotropy by epinephrine-norepinephrine" RELATED []
synonym: "positive control of heart contraction rate by epinephrine-norepinephrine" RELATED []
synonym: "positive regulation of cardiac contraction rate by epinephrine-norepinephrine" EXACT []
synonym: "positive regulation of heart contraction rate by adrenaline-noradrenaline" EXACT []
synonym: "positive regulation of heart contraction rate by epinephrine-norepinephrine" RELATED []
synonym: "stimulation of heart contraction rate by epinephrine-norepinephrine" NARROW []
synonym: "up regulation of heart contraction rate by epinephrine-norepinephrine" EXACT []
synonym: "up-regulation of heart contraction rate by epinephrine-norepinephrine" EXACT []
synonym: "upregulation of heart contraction rate by epinephrine-norepinephrine" EXACT []
is_a: GO:0010460 ! positive regulation of heart rate
relationship: part_of GO:0003321 ! positive regulation of blood pressure by epinephrine-norepinephrine

[Term]
id: GO:0001997
name: positive regulation of the force of heart contraction by epinephrine-norepinephrine
namespace: biological_process
def: "Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine in the bloodstream or released from the nerve endings." [GOC:dph, GOC:mtg_cardio]
synonym: "increased force of heart contraction by adrenaline-noradrenaline" EXACT []
synonym: "increased force of heart contraction by epinephrine-norepinephrine" EXACT []
synonym: "increased inotropy by epinephrine-norepinephrine" RELATED []
synonym: "increased strength of cardiac contraction by epinephrine-norepinephrine" EXACT []
synonym: "positive regulation of heart contraction by adrenaline-noradrenaline" RELATED []
synonym: "positive regulation of heart contraction by epinephrine-norepinephrine" RELATED []
is_a: GO:0003099 ! positive regulation of the force of heart contraction by chemical signal
relationship: part_of GO:0003321 ! positive regulation of blood pressure by epinephrine-norepinephrine

[Term]
id: GO:0001998
name: angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure
namespace: biological_process
def: "The decrease in blood vessel diameter as a result of the release of angiotensin into the blood stream." [GOC:mtg_cardio, ISBN:0721643949]
synonym: "angiotensin mediated vasoconstriction during blood pressure control" RELATED []
synonym: "angiotensin mediated vasoconstriction during blood pressure regulation" EXACT []
synonym: "angiotensin mediated vasoconstriction during control of blood pressure" RELATED []
is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure
is_a: GO:0042310 ! vasoconstriction
relationship: part_of GO:0002034 ! regulation of blood vessel size by renin-angiotensin

[Term]
id: GO:0001999
name: renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure
namespace: biological_process
def: "The physiological response of the kidneys to a decrease in blood flow." [GOC:dph]
synonym: "renal response to blood flow during renin-angiotensin control of blood pressure" RELATED []
is_a: GO:0003071 ! renal system process involved in regulation of systemic arterial blood pressure
relationship: part_of GO:0001991 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin

[Term]
id: GO:0002000
name: detection of renal blood flow
namespace: biological_process
def: "The process in which the juxtaglomerular cells of the kidneys receive information about the amount of blood flowing through the arterioles and converts the information to a molecular signal." [ISBN:0721643949]
is_a: GO:0050982 ! detection of mechanical stimulus
relationship: part_of GO:0001999 ! renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure

[Term]
id: GO:0002001
name: renin secretion into blood stream
namespace: biological_process
def: "The regulated release of renin into the blood stream by juxtoglomerular cells." [ISBN:0721643949]
synonym: "renin release into blood stream" EXACT []
is_a: GO:0009306 ! protein secretion
relationship: part_of GO:0001999 ! renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure

[Term]
id: GO:0002002
name: regulation of angiotensin levels in blood
namespace: biological_process
def: "The process that modulates the level of angiotensin in the blood by balancing the maturation of renin substrate to mature angiotensin and the catabolism of mature angiotensin." [GOC:dph]
synonym: "control of angiotensin levels in blood" RELATED []
synonym: "control of blood angiotensin level" RELATED []
synonym: "regulation of blood angiotensin level" EXACT []
is_a: GO:0010817 ! regulation of hormone levels
is_a: GO:0060177 ! regulation of angiotensin metabolic process
relationship: part_of GO:0001991 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin

[Term]
id: GO:0002003
name: angiotensin maturation
namespace: biological_process
def: "The process leading to the attainment of the full functional capacity of angiotensin by conversion of renin substrate into mature angiotensin in the blood." [ISBN:0721643949]
is_a: GO:0016486 ! peptide hormone processing
relationship: part_of GO:0002002 ! regulation of angiotensin levels in blood

[Term]
id: GO:0002004
name: secretion of vasopressin involved in fast regulation of systemic arterial blood pressure
namespace: biological_process
def: "The regulated release of the hormone vasopressin into the blood stream by the hypothalamus and pituitary gland contributing to fast regulation of blood pressure." [ISBN:0721643949]
synonym: "secretion of vasopressin during fast control of blood pressure" RELATED []
synonym: "secretion of vasopressin during fast regulation of systemic arterial blood pressure" RELATED [GOC:dph]
is_a: GO:0030103 ! vasopressin secretion
relationship: part_of GO:0001992 ! regulation of systemic arterial blood pressure by vasopressin

[Term]
id: GO:0002005
name: angiotensin catabolic process in blood
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of angiotensin in the blood." [ISBN:0721643949]
is_a: GO:0043171 ! peptide catabolic process
is_a: GO:0044254 ! multicellular organismal protein catabolic process
is_a: GO:0044763 ! single-organism cellular process
relationship: part_of GO:0002002 ! regulation of angiotensin levels in blood

[Term]
id: GO:0002006
name: vasoconstriction by vasopressin involved in systemic arterial blood pressure control
namespace: biological_process
def: "The decrease in blood vessel diameter as a result of the release of vasopressin into the blood stream." [GOC:dph, GOC:mtg_cardio, GOC:tb, ISBN:0721643949]
synonym: "vasopressin mediated vasoconstriction involved in systemic arterial blood pressure control" EXACT [GOC:dph, GOC:tb]
is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure
is_a: GO:0042310 ! vasoconstriction
relationship: part_of GO:0001992 ! regulation of systemic arterial blood pressure by vasopressin

[Term]
id: GO:0002007
name: detection of hypoxic conditions in blood by chemoreceptor signaling
namespace: biological_process
def: "The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies." [GOC:dph]
synonym: "detection of hypoxic conditions in blood by chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0009593 ! detection of chemical stimulus
relationship: has_part GO:0003022 ! detection of pH by chemoreceptor signaling
relationship: part_of GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling
relationship: part_of GO:0070887 ! cellular response to chemical stimulus

[Term]
id: GO:0002008
name: excitation of vasomotor center by chemoreceptor signaling
namespace: biological_process
def: "The process in which the molecular signal from the carotid and aortic bodies is relayed to the vasomotor center, causing it to signal an increase arterial pressure." [GOC:dph]
synonym: "excitation of vasomotor center by chemoreceptor signalling" EXACT []
is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure
relationship: part_of GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling
relationship: part_of GO:0003084 ! positive regulation of systemic arterial blood pressure

[Term]
id: GO:0002009
name: morphogenesis of an epithelium
namespace: biological_process
def: "The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732]
synonym: "epithelium morphogenesis" EXACT []
is_a: GO:0048729 ! tissue morphogenesis
relationship: part_of GO:0060429 ! epithelium development

[Term]
id: GO:0002010
name: excitation of vasomotor center by baroreceptor signaling
namespace: biological_process
def: "The process in which the molecular signal from the arterial baroreceptors is relayed to the vasomotor center causing it to signal increase arterial pressure." [GOC:dph]
synonym: "excitation of vasomotor center by baroreceptor signalling" EXACT []
is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure
relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure

[Term]
id: GO:0002011
name: morphogenesis of an epithelial sheet
namespace: biological_process
def: "The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells." [GOC:jl]
is_a: GO:0002009 ! morphogenesis of an epithelium

[Term]
id: GO:0002012
name: vasoconstriction of artery involved in chemoreceptor response to lowering of systemic arterial blood pressure
namespace: biological_process
def: "A process that is triggered by vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure." [GOC:dph, GOC:mtg_cardio]
is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure
is_a: GO:0042310 ! vasoconstriction
relationship: part_of GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling

[Term]
id: GO:0002013
name: detection of carbon dioxide by vasomotor center
namespace: biological_process
def: "The process by a carbon dioxide stimulus is received and converted to a molecular signal by the vasomotor center of the central nervous system." [ISBN:0721643949]
is_a: GO:0003031 ! detection of carbon dioxide
relationship: part_of GO:0001980 ! regulation of systemic arterial blood pressure by ischemic conditions

[Term]
id: GO:0002014
name: vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure
namespace: biological_process
def: "The vasoconstriction that is triggered by vasomotor excitation resulting from the detection of high carbon dioxide levels in the vasomotor center of the central nervous system." [GOC:mtg_cardio, ISBN:0721643949]
is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure
is_a: GO:0042310 ! vasoconstriction
relationship: part_of GO:0001980 ! regulation of systemic arterial blood pressure by ischemic conditions

[Term]
id: GO:0002015
name: regulation of systemic arterial blood pressure by atrial baroreceptor feedback
namespace: biological_process
def: "A process that controls blood pressure by sensing the amount of stretch occurring in the atria." [GOC:dph, GOC:tb]
synonym: "atrial baroreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb]
synonym: "atrial control of blood pressure" RELATED []
synonym: "atrial low pressure baroreceptor regulation of blood pressure" EXACT [GOC:mtg_cardio]
synonym: "atrial reflex" RELATED [GOC:dph]
is_a: GO:0003015 ! heart process
relationship: part_of GO:0003025 ! regulation of systemic arterial blood pressure by baroreceptor feedback

[Term]
id: GO:0002016
name: regulation of blood volume by renin-angiotensin
namespace: biological_process
def: "The process in which the renin-angiotensin system controls the rate of fluid intake and output into the blood." [GOC:dph, GOC:mtg_cardio, GOC:tb, ISBN:0721643949]
synonym: "renin-angiotensin control of body fluid levels" RELATED []
synonym: "renin-angiotensin regulation of blood volume" EXACT [GOC:dph, GOC:tb]
is_a: GO:0003081 ! regulation of systemic arterial blood pressure by renin-angiotensin

[Term]
id: GO:0002017
name: regulation of blood volume by renal aldosterone
namespace: biological_process
def: "The process in which the hormone aldosterone decreases the rate of diuresis and natriuresis resulting in increased blood volume." [GOC:dph, GOC:tb, ISBN:0721643949]
synonym: "aldosterone mediated control of body fluids" RELATED []
synonym: "aldosterone mediated regulation of blood volume" EXACT [GOC:dph, GOC:tb]
synonym: "renal regulation of blood volume by aldosterone" EXACT [GOC:dph, GOC:tb]
is_a: GO:0001977 ! renal system process involved in regulation of blood volume
is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone
is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure

[Term]
id: GO:0002018
name: renin-angiotensin regulation of aldosterone production
namespace: biological_process
def: "The process in which an increase in active angiotensin stimulates the adrenal cortices to secrete aldosterone." [ISBN:0721643949]
synonym: "renin-angiotensin control of aldosterone production" RELATED []
is_a: GO:0003071 ! renal system process involved in regulation of systemic arterial blood pressure
is_a: GO:2000858 ! regulation of aldosterone secretion
intersection_of: GO:0003014 ! renal system process
intersection_of: part_of GO:0002016 ! regulation of blood volume by renin-angiotensin
intersection_of: regulates GO:0035932 ! aldosterone secretion
relationship: part_of GO:0002016 ! regulation of blood volume by renin-angiotensin
relationship: regulates GO:0035932 ! aldosterone secretion

[Term]
id: GO:0002019
name: regulation of renal output by angiotensin
namespace: biological_process
def: "The process in which angiotensin directly modulates the rate of urine output by the kidney." [GOC:dph, GOC:mtg_cardio, GOC:tb, ISBN:0721643949]
synonym: "angiotensin mediated control of renal output" RELATED []
synonym: "angiotensin mediated regulation of renal output" EXACT [GOC:dph, GOC:tb]
synonym: "angiotensin-mediated regulation of renal output" EXACT [GOC:dph, GOC:tb]
is_a: GO:0002016 ! regulation of blood volume by renin-angiotensin

[Term]
id: GO:0002020
name: protease binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any protease or peptidase." [GOC:hjd]
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0002021
name: response to dietary excess
namespace: biological_process
def: "The physiological process in which dietary excess is sensed by the central nervous system, resulting in a reduction in food intake and increased energy expenditure." [GOC:pg, GOC:pr, PMID:12161655]
is_a: GO:0031667 ! response to nutrient levels
is_a: GO:0044707 ! single-multicellular organism process

[Term]
id: GO:0002022
name: detection of dietary excess
namespace: biological_process
def: "The neurological process in which the brain senses excessive caloric intake." [PMID:12161655]
is_a: GO:0050877 ! neurological system process
relationship: part_of GO:0002021 ! response to dietary excess

[Term]
id: GO:0002023
name: reduction of food intake in response to dietary excess
namespace: biological_process
def: "An eating behavior process whereby detection of a dietary excess results in a decrease in intake of nutrients." [GOC:pg, GOC:pr, PMID:12161655, PMID:12840200]
is_a: GO:0042755 ! eating behavior
relationship: part_of GO:0002021 ! response to dietary excess

[Term]
id: GO:0002024
name: diet induced thermogenesis
namespace: biological_process
def: "The process that results in increased metabolic rate in tissues of an organism. It is triggered by the detection of dietary excess. This process is achieved via signalling in the sympathetic nervous system." [PMID:12161655]
is_a: GO:1990845 ! adaptive thermogenesis
relationship: part_of GO:0002021 ! response to dietary excess

[Term]
id: GO:0002025
name: vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure
namespace: biological_process
def: "A process that results in an increase in the diameter of an artery during the norepinephrine-epinephrine response to blood pressure change." [GOC:mtg_cardio, PMID:10358008]
synonym: "noradrenaline-adrenaline vasodilation involved in regulation of blood pressure" EXACT []
synonym: "norepinephrine-epinephrine vasodilation during blood pressure regulation" EXACT []
is_a: GO:0003085 ! negative regulation of systemic arterial blood pressure
is_a: GO:0042311 ! vasodilation
relationship: part_of GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine

[Term]
id: GO:0002026
name: regulation of the force of heart contraction
namespace: biological_process
def: "Any process that modulates the extent of heart contraction, changing the force with which blood is propelled." [GOC:dph, GOC:tb, PMID:10358008]
synonym: "cardiac inotropy" EXACT [GOC:dph, GOC:tb]
synonym: "heart inotropy" EXACT []
is_a: GO:0008016 ! regulation of heart contraction
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0002027
name: regulation of heart rate
namespace: biological_process
def: "Any process that modulates the frequency or rate of heart contraction." [GOC:dph, GOC:tb, PMID:10358008]
synonym: "cardiac chronotropy" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of heart contraction rate" EXACT []
synonym: "regulation of rate of heart contraction" EXACT []
is_a: GO:0008016 ! regulation of heart contraction
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0002028
name: regulation of sodium ion transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph]
synonym: "regulation of Na+ transport" EXACT []
synonym: "regulation of sodium transport" EXACT []
is_a: GO:0010959 ! regulation of metal ion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006814 ! sodium ion transport
relationship: regulates GO:0006814 ! sodium ion transport

[Term]
id: GO:0002029
name: desensitization of G-protein coupled receptor protein signaling pathway
namespace: biological_process
def: "The process that stops, prevents, or reduces the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity after prolonged stimulation with an agonist of the pathway." [PMID:8396717]
synonym: "desensitisation of G-protein coupled receptor protein signalling pathway" EXACT []
is_a: GO:0022401 ! negative adaptation of signaling pathway
is_a: GO:0045744 ! negative regulation of G-protein coupled receptor protein signaling pathway

[Term]
id: GO:0002030
name: inhibitory G-protein coupled receptor phosphorylation
namespace: biological_process
def: "The process that inhibits the signaling function of a G-protein coupled receptor by addition of a phosphate group to its third intracellular loop consensus site." [PMID:8396717]
is_a: GO:0006468 ! protein phosphorylation
relationship: part_of GO:0002029 ! desensitization of G-protein coupled receptor protein signaling pathway

[Term]
id: GO:0002031
name: G-protein coupled receptor internalization
namespace: biological_process
def: "The process that results in the uptake of a G-protein coupled receptor into an endocytic vesicle." [PMID:8396717]
is_a: GO:0031623 ! receptor internalization
relationship: part_of GO:0002029 ! desensitization of G-protein coupled receptor protein signaling pathway

[Term]
id: GO:0002032
name: desensitization of G-protein coupled receptor protein signaling pathway by arrestin
namespace: biological_process
def: "The process that inhibits the signaling function of a G-protein coupled receptor by uncoupling the receptor from its downstream G proteins." [GOC:dph, GOC:tb, PMID:8396717]
synonym: "arrestin mediated desensitisation of G-protein coupled receptor protein signalling pathway" EXACT []
synonym: "arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway" EXACT [GOC:dph, GOC:tb]
synonym: "arrestin-mediated desensitization of G-protein coupled receptor protein signaling pathway" EXACT []
is_a: GO:0002029 ! desensitization of G-protein coupled receptor protein signaling pathway
is_a: GO:0032091 ! negative regulation of protein binding

[Term]
id: GO:0002033
name: vasodilation by angiotensin involved in regulation of systemic arterial blood pressure
namespace: biological_process
def: "The process that increases the size of a blood vessel via the renin-angiotensin system." [ISBN:0323031951, PMID:10425188]
is_a: GO:0003085 ! negative regulation of systemic arterial blood pressure
is_a: GO:0042311 ! vasodilation
relationship: part_of GO:0002034 ! regulation of blood vessel size by renin-angiotensin

[Term]
id: GO:0002034
name: regulation of blood vessel size by renin-angiotensin
namespace: biological_process
def: "The process in which the diameter of a blood vessel is changed due to activity of the renin-angiotensin system." [GOC:dph, GOC:tb]
synonym: "renin-angiotensin regulation of blood vessel size" EXACT [GOC:dph, GOC:tb]
is_a: GO:0003072 ! renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure
is_a: GO:0003081 ! regulation of systemic arterial blood pressure by renin-angiotensin
is_a: GO:0050880 ! regulation of blood vessel size

[Term]
id: GO:0002035
name: brain renin-angiotensin system
namespace: biological_process
def: "The process in which an angiotensin-mediated signaling system present in the brain regulates the force with which blood passes through the circulatory system." [PMID:2909574]
is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure
is_a: GO:0002016 ! regulation of blood volume by renin-angiotensin

[Term]
id: GO:0002036
name: regulation of L-glutamate transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of L-glutamate transport." [GOC:hjd]
is_a: GO:0051955 ! regulation of amino acid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0015813 ! L-glutamate transport
relationship: regulates GO:0015813 ! L-glutamate transport

[Term]
id: GO:0002037
name: negative regulation of L-glutamate transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of L-glutamate transport." [GOC:hjd]
synonym: "down regulation of L-glutamate transport" EXACT []
synonym: "down-regulation of L-glutamate transport" EXACT []
synonym: "downregulation of L-glutamate transport" EXACT []
synonym: "inhibition of L-glutamate transport" NARROW []
is_a: GO:0002036 ! regulation of L-glutamate transport
is_a: GO:0051956 ! negative regulation of amino acid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0015813 ! L-glutamate transport
relationship: negatively_regulates GO:0015813 ! L-glutamate transport

[Term]
id: GO:0002038
name: positive regulation of L-glutamate transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of L-glutamate transport." [GOC:hjd]
synonym: "activation of L-glutamate transport" NARROW []
synonym: "stimulation of L-glutamate transport" NARROW []
synonym: "up regulation of L-glutamate transport" EXACT []
synonym: "up-regulation of L-glutamate transport" EXACT []
synonym: "upregulation of L-glutamate transport" EXACT []
is_a: GO:0002036 ! regulation of L-glutamate transport
is_a: GO:0051957 ! positive regulation of amino acid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0015813 ! L-glutamate transport
relationship: positively_regulates GO:0015813 ! L-glutamate transport

[Term]
id: GO:0002039
name: p53 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with one of the p53 family of proteins." [GOC:hjd]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0002040
name: sprouting angiogenesis
namespace: biological_process
def: "The extension of new blood vessels from existing capillaries into avascular tissues resulting from the proliferation of blood vessel endothelial cells." [PMID:16391003]
is_a: GO:0001525 ! angiogenesis

[Term]
id: GO:0002041
name: intussusceptive angiogenesis
namespace: biological_process
def: "The formation of new blood vessels as a result of the insertion and extension of lumenal tissue pillars." [PMID:16391003]
is_a: GO:0001525 ! angiogenesis

[Term]
id: GO:0002042
name: cell migration involved in sprouting angiogenesis
namespace: biological_process
def: "The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis." [PMID:16391003]
is_a: GO:0043534 ! blood vessel endothelial cell migration
relationship: part_of GO:0002040 ! sprouting angiogenesis

[Term]
id: GO:0002043
name: blood vessel endothelial cell proliferation involved in sprouting angiogenesis
namespace: biological_process
def: "The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population contributing to sprouting angiogenesis." [GOC:dph, GOC:tb, PMID:16391003]
synonym: "blood vessel endothelial cell proliferation during sprouting angiogenesis" RELATED [GOC:dph, GOC:tb]
is_a: GO:0001935 ! endothelial cell proliferation
relationship: part_of GO:0002040 ! sprouting angiogenesis

[Term]
id: GO:0002044
name: blood vessel endothelial cell migration involved in intussusceptive angiogenesis
namespace: biological_process
def: "The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels during intussusceptive angiogenesis." [PMID:16391003]
is_a: GO:0043534 ! blood vessel endothelial cell migration
relationship: part_of GO:0002041 ! intussusceptive angiogenesis

[Term]
id: GO:0002045
name: regulation of cell adhesion involved in intussusceptive angiogenesis
namespace: biological_process
def: "The process that modulates the frequency, rate or extent of attachment of a blood vessel endothelial cell to another cell or to the extracellular matrix involved in intussusceptive angiogenesis." [PMID:16391003]
is_a: GO:0030155 ! regulation of cell adhesion
intersection_of: GO:0030155 ! regulation of cell adhesion
intersection_of: part_of GO:0002041 ! intussusceptive angiogenesis
relationship: part_of GO:0002041 ! intussusceptive angiogenesis

[Term]
id: GO:0002046
name: opsin binding
namespace: molecular_function
alt_id: GO:0016030
def: "Interacting selectively and non-covalently with an opsin, any of a group of hydrophobic, integral membrane glycoproteins located primarily in the disc membrane of rods or cones, involved in photoreception." [GOC:hjd]
synonym: "metarhodopsin binding" NARROW []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0002047
name: phenazine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a phenazine antibiotic, a polycyclic pyrazine with two nitrogen atoms in the ring." [GOC:dph]
subset: gosubset_prok
synonym: "acridizine biosynthesis" RELATED []
synonym: "acridizine biosynthetic process" RELATED []
synonym: "azophenylene biosynthesis" RELATED []
synonym: "azophenylene biosynthetic process" RELATED []
synonym: "dibenzo-p-diazine biosynthesis" RELATED []
synonym: "dibenzo-p-diazine biosynthetic process" RELATED []
synonym: "dibenzopyrazine biosynthesis" RELATED []
synonym: "dibenzopyrazine biosynthetic process" RELATED []
is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process

[Term]
id: GO:0002048
name: pyoverdine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the siderochrome pyoverdine." [PMID:15317763]
synonym: "pyoverdine metabolism" EXACT []
is_a: GO:0009237 ! siderophore metabolic process

[Term]
id: GO:0002049
name: pyoverdine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the siderochrome pyoverdine." [PMID:15317763]
is_a: GO:0002048 ! pyoverdine metabolic process
is_a: GO:0019290 ! siderophore biosynthetic process

[Term]
id: GO:0002050
name: pyoverdine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the siderochrome pyoverdine." [PMID:15317763]
is_a: GO:0002048 ! pyoverdine metabolic process
is_a: GO:0046215 ! siderophore catabolic process

[Term]
id: GO:0002051
name: osteoblast fate commitment
namespace: biological_process
def: "The commitment of mesenchymal cells to the specific cell fate of an osteoblast. An osteoblast is a bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone." [GOC:dph]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0001649 ! osteoblast differentiation

[Term]
id: GO:0002052
name: positive regulation of neuroblast proliferation
namespace: biological_process
def: "Any process that activates or increases the rate of neuroblast proliferation." [GOC:dph]
synonym: "activation of neuroblast proliferation" NARROW []
synonym: "stimulation of neuroblast proliferation" NARROW []
synonym: "up regulation of neuroblast proliferation" EXACT []
synonym: "up-regulation of neuroblast proliferation" EXACT []
synonym: "upregulation of neuroblast proliferation" EXACT []
is_a: GO:0050769 ! positive regulation of neurogenesis
is_a: GO:1902692 ! regulation of neuroblast proliferation
is_a: GO:2000179 ! positive regulation of neural precursor cell proliferation
is_a: GO:2000648 ! positive regulation of stem cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007405 ! neuroblast proliferation
relationship: positively_regulates GO:0007405 ! neuroblast proliferation

[Term]
id: GO:0002053
name: positive regulation of mesenchymal cell proliferation
namespace: biological_process
def: "The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells." [GOC:dph]
synonym: "activation of mesenchymal cell proliferation" NARROW []
synonym: "stimulation of mesenchymal cell proliferation" NARROW []
synonym: "up regulation of mesenchymal cell proliferation" EXACT []
synonym: "up-regulation of mesenchymal cell proliferation" EXACT []
synonym: "upregulation of mesenchymal cell proliferation" EXACT []
is_a: GO:0010464 ! regulation of mesenchymal cell proliferation
is_a: GO:2000648 ! positive regulation of stem cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010463 ! mesenchymal cell proliferation
relationship: positively_regulates GO:0010463 ! mesenchymal cell proliferation

[Term]
id: GO:0002054
name: nucleobase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a nucleobase, any of a class of pyrmidines or purines, organic nitrogenous bases." [GOC:hjd]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0036094 ! small molecule binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding

[Term]
id: GO:0002055
name: adenine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with adenine, a purine base." [GOC:hjd]
synonym: "6-aminopurine binding" EXACT []
is_a: GO:0002060 ! purine nucleobase binding

[Term]
id: GO:0002056
name: cytosine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with cytosine." [GOC:hjd, GOC:vw]
is_a: GO:0002061 ! pyrimidine nucleobase binding

[Term]
id: GO:0002057
name: guanine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with guanine." [GOC:hjd]
is_a: GO:0002060 ! purine nucleobase binding

[Term]
id: GO:0002058
name: uracil binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with uracil." [GOC:hjd]
is_a: GO:0002061 ! pyrimidine nucleobase binding

[Term]
id: GO:0002059
name: thymine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with thymine." [GOC:hjd]
is_a: GO:0002061 ! pyrimidine nucleobase binding

[Term]
id: GO:0002060
name: purine nucleobase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a purine nucleobase, an organic nitrogenous base with a purine skeleton." [CHEBI:26386, GOC:hjd]
synonym: "purine base binding" EXACT [GOC:go_curators]
synonym: "purine binding" RELATED [GOC:curators]
is_a: GO:0002054 ! nucleobase binding

[Term]
id: GO:0002061
name: pyrimidine nucleobase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a pyrimidine nucleobase, an organic nitrogenous base with a pyrimidine skeleton." [CHEBI:26432, GOC:hjd]
synonym: "1,3-diazine binding" NARROW []
synonym: "pyrimidine base binding" EXACT [GOC:go_curators]
synonym: "pyrimidine binding" RELATED [GOC:curators]
is_a: GO:0002054 ! nucleobase binding

[Term]
id: GO:0002062
name: chondrocyte differentiation
namespace: biological_process
def: "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage." [GOC:dph]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0051216 ! cartilage development

[Term]
id: GO:0002063
name: chondrocyte development
namespace: biological_process
def: "The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate." [GOC:dph]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0002062 ! chondrocyte differentiation

[Term]
id: GO:0002064
name: epithelial cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0030855 ! epithelial cell differentiation

[Term]
id: GO:0002065
name: columnar/cuboidal epithelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph]
is_a: GO:0030855 ! epithelial cell differentiation

[Term]
id: GO:0002066
name: columnar/cuboidal epithelial cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph]
is_a: GO:0002064 ! epithelial cell development
relationship: part_of GO:0002065 ! columnar/cuboidal epithelial cell differentiation

[Term]
id: GO:0002067
name: glandular epithelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a glandular epithelial cell. A glandular epithelial cell is a columnar/cuboidal epithelial cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph]
is_a: GO:0002065 ! columnar/cuboidal epithelial cell differentiation

[Term]
id: GO:0002068
name: glandular epithelial cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph]
is_a: GO:0002066 ! columnar/cuboidal epithelial cell development
relationship: part_of GO:0002067 ! glandular epithelial cell differentiation

[Term]
id: GO:0002069
name: columnar/cuboidal epithelial cell maturation
namespace: biological_process
def: "The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell to attain its fully functional state. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph]
is_a: GO:0002070 ! epithelial cell maturation
relationship: part_of GO:0002066 ! columnar/cuboidal epithelial cell development

[Term]
id: GO:0002070
name: epithelial cell maturation
namespace: biological_process
def: "The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph]
is_a: GO:0048469 ! cell maturation
relationship: part_of GO:0002064 ! epithelial cell development

[Term]
id: GO:0002071
name: glandular epithelial cell maturation
namespace: biological_process
def: "The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph]
is_a: GO:0002069 ! columnar/cuboidal epithelial cell maturation
relationship: part_of GO:0002068 ! glandular epithelial cell development

[Term]
id: GO:0002072
name: optic cup morphogenesis involved in camera-type eye development
namespace: biological_process
def: "The invagination of the optic vesicle to form two-walled indentations, the optic cups, that will go on to form the retina. This process begins with the optic vesicle becoming a two-walled structure and its subsequent shape changes. It does not include the fate commitment of cells to become the pigmented retina and the neural retina. An example of this process is found in Mus musculus." [GOC:dph, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb, ISBN:0878932437]
synonym: "optic cup morphogenesis involved in camera-style eye development" EXACT []
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
relationship: part_of GO:0060900 ! embryonic camera-type eye formation

[Term]
id: GO:0002074
name: extraocular skeletal muscle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. An example of this process is found in Mus musculus." [GOC:dph, GOC:mtg_muscle, GOC:mtg_sensu, MA:0001271, PMID:16638982]
is_a: GO:0007519 ! skeletal muscle tissue development
is_a: GO:0060538 ! skeletal muscle organ development
relationship: part_of GO:0043010 ! camera-type eye development

[Term]
id: GO:0002075
name: somitomeric trunk muscle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the somitomeric trunk muscle over time, from its formation to the mature structure. The somitomeric trunk muscle is derived from somitomeric mesoderm. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. An example of this process is found in Mus musculus." [GOC:dph, PMID:16638982]
is_a: GO:0007519 ! skeletal muscle tissue development
is_a: GO:0060538 ! skeletal muscle organ development

[Term]
id: GO:0002076
name: osteoblast development
namespace: biological_process
def: "The process whose specific outcome is the progression of an osteoblast over time, from its formation to the mature structure. Osteoblast development does not include the steps involved in committing a cranial neural crest cell or an osteoprogenitor cell to an osteoblast fate. An osteoblast is a cell that gives rise to bone." [GOC:dph]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0001649 ! osteoblast differentiation

[Term]
id: GO:0002077
name: acrosome matrix dispersal
namespace: biological_process
def: "The proteolytic digestion of components in the acrosomal matrix that allows for their release into the egg. The dispersal of the components allows for the inner acrosomal membrane to interact with the egg." [GOC:dph, PMID:3886029]
is_a: GO:0022414 ! reproductive process
is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process
relationship: part_of GO:0007340 ! acrosome reaction

[Term]
id: GO:0002078
name: membrane fusion involved in acrosome reaction
namespace: biological_process
def: "The fusion of the plasma membrane of the sperm with the outer acrosomal membrane." [GOC:dph, PMID:3886029]
synonym: "membrane fusion involved in the acrosomal reaction" EXACT []
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0044801 ! single-organism membrane fusion
intersection_of: GO:0061025 ! membrane fusion
intersection_of: part_of GO:0007340 ! acrosome reaction
relationship: part_of GO:0007340 ! acrosome reaction

[Term]
id: GO:0002079
name: inner acrosomal membrane
namespace: cellular_component
def: "The acrosomal membrane region that underlies the acrosomal vesicle and is located toward the sperm nucleus. This region is responsible for molecular interactions allowing the sperm to penetrate the zona pellucida and fuses with the egg plasma membrane." [GOC:dph, PMID:3899643, PMID:8936405]
comment: Note that this term is not a descendant of 'organelle inner membrane ; GO:0019866' because the outer acrosomal membrane is a portion of the acrosomal membrane; the latter is a single lipid bilayer.
is_a: GO:0044433 ! cytoplasmic vesicle part
is_a: GO:0097223 ! sperm part
is_a: GO:0098589 ! membrane region
relationship: part_of GO:0002080 ! acrosomal membrane

[Term]
id: GO:0002080
name: acrosomal membrane
namespace: cellular_component
def: "The membrane that surrounds the acrosomal lumen. The acrosome is a special type of lysosome in the head of a spermatozoon that contains acid hydrolases and is concerned with the breakdown of the outer membrane of the ovum during fertilization." [GOC:dph]
is_a: GO:0030667 ! secretory granule membrane
is_a: GO:0097223 ! sperm part
relationship: part_of GO:0001669 ! acrosomal vesicle

[Term]
id: GO:0002081
name: outer acrosomal membrane
namespace: cellular_component
def: "The acrosomal membrane region that underlies the plasma membrane of the sperm. This membrane fuses with the sperm plasma membrane as part of the acrosome reaction." [GOC:dph, PMID:8936405]
comment: Note that this term is not a descendant of 'organelle outer membrane ; GO:0031968' because the outer acrosomal membrane is a portion of the acrosomal membrane; the latter is a single lipid bilayer.
is_a: GO:0044433 ! cytoplasmic vesicle part
is_a: GO:0097223 ! sperm part
is_a: GO:0098589 ! membrane region
relationship: part_of GO:0002080 ! acrosomal membrane

[Term]
id: GO:0002082
name: regulation of oxidative phosphorylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis." [GOC:dph]
is_a: GO:0042325 ! regulation of phosphorylation
is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy
is_a: GO:1903578 ! regulation of ATP metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006119 ! oxidative phosphorylation
relationship: regulates GO:0006119 ! oxidative phosphorylation

[Term]
id: GO:0002083
name: 4-hydroxybenzoate decaprenyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: all-trans-decaprenyl diphosphate + 4-hydroxybenzoate = 3-decaprenyl-4-hydroxybenzoate + diphosphate." [MetaCyc:RXN-9230]
xref: EC:2.5.1.39
xref: MetaCyc:RXN-9230
is_a: GO:0002094 ! polyprenyltransferase activity

[Term]
id: GO:0002084
name: protein depalmitoylation
namespace: biological_process
def: "The removal of palymitoyl groups from a lipoprotein." [GOC:hjd]
is_a: GO:0035601 ! protein deacylation
is_a: GO:0042159 ! lipoprotein catabolic process
is_a: GO:0098734 ! macromolecule depalmitoylation

[Term]
id: GO:0002085
name: inhibition of neuroepithelial cell differentiation
namespace: biological_process
def: "Any process that prevents the activation of neuroepithelial cell differentiation. Neuroepithelial cell differentiation is the process in which epiblast cells acquire specialized features of neuroepithelial cells." [GOC:dph, PMID:16678814]
synonym: "negative regulation of neural plate formation" NARROW [GOC:dph, GOC:tb]
synonym: "repression of premature neural plate formation" NARROW [GOC:dph, GOC:tb]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0030857 ! negative regulation of epithelial cell differentiation
is_a: GO:0045995 ! regulation of embryonic development
is_a: GO:0048505 ! regulation of timing of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060563 ! neuroepithelial cell differentiation
relationship: negatively_regulates GO:0060563 ! neuroepithelial cell differentiation

[Term]
id: GO:0002086
name: diaphragm contraction
namespace: biological_process
def: "A process in which force is generated within involuntary skeletal muscle tissue, resulting in a change in muscle geometry. This process occurs in the diaphragm. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The diaphragm is a striated muscle that is necessary for the process of respiratory gaseous exchange." [GOC:dph, GOC:mtg_muscle, PMID:12458206]
is_a: GO:0003011 ! involuntary skeletal muscle contraction
is_a: GO:0003016 ! respiratory system process

[Term]
id: GO:0002087
name: regulation of respiratory gaseous exchange by neurological system process
namespace: biological_process
def: "A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates." [GOC:dph, GOC:tb, PMID:12458206]
synonym: "neurological control of breathing" EXACT [GOC:dph, GOC:tb]
is_a: GO:0044065 ! regulation of respiratory system process
is_a: GO:0050877 ! neurological system process
intersection_of: GO:0050877 ! neurological system process
intersection_of: regulates GO:0007585 ! respiratory gaseous exchange
relationship: regulates GO:0007585 ! respiratory gaseous exchange

[Term]
id: GO:0002088
name: lens development in camera-type eye
namespace: biological_process
def: "The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus." [GOC:dph, ISBN:0582064333]
synonym: "lens development" EXACT []
synonym: "lens development in camera-style eye" EXACT []
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0043010 ! camera-type eye development

[Term]
id: GO:0002089
name: lens morphogenesis in camera-type eye
namespace: biological_process
def: "The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus." [GOC:dph, GOC:mtg_sensu]
synonym: "lens morphogenesis" EXACT []
synonym: "lens morphogenesis in camera-style eye" EXACT []
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0002088 ! lens development in camera-type eye
relationship: part_of GO:0048593 ! camera-type eye morphogenesis

[Term]
id: GO:0002090
name: regulation of receptor internalization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of receptor internalization." [GOC:hjd]
is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:0048259 ! regulation of receptor-mediated endocytosis
is_a: GO:0060255 ! regulation of macromolecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031623 ! receptor internalization
relationship: regulates GO:0031623 ! receptor internalization

[Term]
id: GO:0002091
name: negative regulation of receptor internalization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of receptor internalization." [GOC:hjd]
synonym: "down regulation of receptor internalization" EXACT []
synonym: "down-regulation of receptor internalization" EXACT []
synonym: "downregulation of receptor internalization" EXACT []
synonym: "inhibition of receptor internalization" NARROW []
is_a: GO:0002090 ! regulation of receptor internalization
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0048261 ! negative regulation of receptor-mediated endocytosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0031623 ! receptor internalization
relationship: negatively_regulates GO:0031623 ! receptor internalization

[Term]
id: GO:0002092
name: positive regulation of receptor internalization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of receptor internalization." [GOC:hjd]
synonym: "activation of receptor internalization" NARROW []
synonym: "stimulation of receptor internalization" NARROW []
synonym: "up regulation of receptor internalization" EXACT []
synonym: "up-regulation of receptor internalization" EXACT []
synonym: "upregulation of receptor internalization" EXACT []
is_a: GO:0002090 ! regulation of receptor internalization
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0048260 ! positive regulation of receptor-mediated endocytosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0031623 ! receptor internalization
relationship: positively_regulates GO:0031623 ! receptor internalization

[Term]
id: GO:0002093
name: auditory receptor cell morphogenesis
namespace: biological_process
def: "Any process that alters the size or shape of an auditory receptor cell." [GOC:dph, GOC:tb]
synonym: "hair cell morphogenesis" BROAD [GO:dph]
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0048667 ! cell morphogenesis involved in neuron differentiation
relationship: part_of GO:0042472 ! inner ear morphogenesis
relationship: part_of GO:0060117 ! auditory receptor cell development

[Term]
id: GO:0002094
name: polyprenyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of multiple prenyl groups from one compound (donor) to another (acceptor)." [GOC:hjd]
subset: gosubset_prok
is_a: GO:0004659 ! prenyltransferase activity

[Term]
id: GO:0002095
name: caveolar macromolecular signaling complex
namespace: cellular_component
def: "A complex composed of proteins required for beta adrenergic receptor activation of protein kinase A. It includes the Cav 12. subunit of L-type calcium channel, protein kinase A regulatory subunit 2(PKAR2), adenyl cyclase, beta-adrenergic receptor, G-alpha-S, protein phosphatase 2A (PP2A) and caveolin 3 (CAV3)." [PMID:16648270]
synonym: "caveolar macromolecular signalling complex" EXACT []
is_a: GO:0098797 ! plasma membrane protein complex
relationship: part_of GO:0005901 ! caveola

[Term]
id: GO:0002096
name: polkadots
namespace: cellular_component
def: "A punctate, filamentous structure composed of Bcl10 that appears in the cytoplasm of T-cells shortly after T-cell receptor stimulation. Polkadots stands for Punctate Oligomeric Killing and Activating DOmains Transducing Signals." [PMID:14724296, PMID:16495340]
comment: Note that polkadots also contains some amount of MALT1. Interaction with MALT1 is required for formation of the polkadots.
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0002097
name: tRNA wobble base modification
namespace: biological_process
def: "The process in which the nucleotide at position 34 in the anticodon of a tRNA is post-transcriptionally modified." [GOC:hjd, ISBN:155581073X]
is_a: GO:0006400 ! tRNA modification

[Term]
id: GO:0002098
name: tRNA wobble uridine modification
namespace: biological_process
def: "The process in which a uridine in position 34 of a tRNA is post-transcriptionally modified." [GOC:hjd, ISBN:155581073X]
is_a: GO:0002097 ! tRNA wobble base modification

[Term]
id: GO:0002099
name: tRNA wobble guanine modification
namespace: biological_process
def: "The process in which a guanine in t position 34 of a tRNA is post-transcriptionally modified." [GOC:hjd, ISBN:155581073X]
is_a: GO:0002097 ! tRNA wobble base modification

[Term]
id: GO:0002100
name: tRNA wobble adenosine to inosine editing
namespace: biological_process
def: "The process in which an adenosine in position 34 of a tRNA is post-transcriptionally converted to inosine." [GOC:hjd, ISBN:155581073X]
is_a: GO:0002097 ! tRNA wobble base modification

[Term]
id: GO:0002101
name: tRNA wobble cytosine modification
namespace: biological_process
def: "The process in which a cytosine in position 34 of a tRNA is post-transcriptionally modified." [GOC:hjd, ISBN:155581073X]
is_a: GO:0002097 ! tRNA wobble base modification

[Term]
id: GO:0002102
name: podosome
namespace: cellular_component
def: "An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm." [PMID:12837608, PMID:15890982]
comment: Note that podosomes can be distinguished from other F-actin-rich structures or from other matrix contacts. For example, focal adhesions and focal contacts do not display a core structure of F-actin. Unlike focal adhesions, podosome assembly does not require de novo protein synthesis. However, most of the podosome ring components are found in focal adhesions and other cell-matrix contacts. Podosomes are typically found in cells that cross tissue boundaries, recruited to the leading edge of migrating cells, and are often sites of extracellular matrix degradation.
xref: Wikipedia:Podosome
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle
is_a: GO:0043234 ! protein complex
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0015629 ! actin cytoskeleton

[Term]
id: GO:0002103
name: endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with four genes, in this order, are produced in the chloroplasts of vascular plants. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators]
is_a: GO:0000478 ! endonucleolytic cleavage involved in rRNA processing

[Term]
id: GO:0002104
name: endonucleolytic cleaveage between 4.5S rRNA and 5S rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage between the 5S rRNA and the 4.5S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators]
is_a: GO:0002103 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)

[Term]
id: GO:0002105
name: endonucleolytic cleaveage between LSU-rRNA and 4.5S rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage between the LSU-rRNA and the 4.5S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators]
is_a: GO:0002103 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)

[Term]
id: GO:0002106
name: endonucleolytic cleaveage between SSU-rRNA and LSU-rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavages between the SSU-rRNA and the LSU-rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. These cleavages liberate tRNAs from the polycistronic transcript as well as separating the SSU and LSU containing transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators]
is_a: GO:0002103 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)

[Term]
id: GO:0002107
name: generation of mature 3'-end of 5S rRNA generated by RNA polymerase III
namespace: biological_process
def: "The removal of extra uridine residues from the 3' end of a 5S pre-rRNA generated by transcription by RNA polymerase III to generate the mature 3'-end." [GOC:hjd, PMID:16387655, PMID:1748637, PMID:1902221, PMID:8389357]
is_a: GO:0000481 ! maturation of 5S rRNA
is_a: GO:0031125 ! rRNA 3'-end processing

[Term]
id: GO:0002108
name: maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S)
namespace: biological_process
def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators]
is_a: GO:0000470 ! maturation of LSU-rRNA

[Term]
id: GO:0002109
name: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S)
namespace: biological_process
def: "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators]
is_a: GO:0030490 ! maturation of SSU-rRNA

[Term]
id: GO:0002110
name: cotranscriptional mitochondrial rRNA nucleotide insertion
namespace: biological_process
def: "The insertion of one or two non-coded nucleotides during the transcription of a mitochondrial rRNA. Such additions are known to occur in myxomycetes such as Physarum, Didymium, and Stemonitis." [GOC:curators, ISBN:1555811337, PMID:8306965]
is_a: GO:0000154 ! rRNA modification
is_a: GO:0070705 ! RNA nucleotide insertion

[Term]
id: GO:0002111
name: BRCA2-BRAF35 complex
namespace: cellular_component
def: "A heterodimeric complex of BRCA2 and BRAF35 (BRCA2-associated factor 35). The BRCA2-BRAF35 complex is often associated with condensed chromatin during mitosis." [GOC:hjd, PMID:11207365]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0002112
name: interleukin-33 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-33 receptor." [GOC:hjd]
synonym: "IL-33" NARROW [GOC:mah]
synonym: "interleukin-33 receptor ligand" NARROW [GOC:mah]
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0002113
name: interleukin-33 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-33." [GOC:hjd]
synonym: "IL-33 binding" EXACT [GOC:mah]
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0002114
name: interleukin-33 receptor activity
namespace: molecular_function
def: "Combining with interleukin-33 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:hjd, GOC:signaling]
synonym: "IL-33 receptor activity" EXACT [GOC:mah]
synonym: "IL-33R" EXACT [GOC:mah]
is_a: GO:0004896 ! cytokine receptor activity
relationship: has_part GO:0002113 ! interleukin-33 binding
relationship: part_of GO:0038172 ! interleukin-33-mediated signaling pathway

[Term]
id: GO:0002115
name: store-operated calcium entry
namespace: biological_process
def: "A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum." [GOC:hjd, PMID:11120592, PMID:17956991]
comment: SOCE is initiated by response to stiumlation of membrane receptors leading to the hydrolysis ofphosphatidylinositol bisphosphate (PIP2), inositol 1,4,5-trisphosphate (IP3) generation, and IP3-mediated calcium ion release from the endoplasmic reticulum.
synonym: "calcium ion import" BROAD []
synonym: "capacitative calcium entry" EXACT []
synonym: "SOCE" EXACT []
synonym: "store-operated calcium import" EXACT []
is_a: GO:0006816 ! calcium ion transport

[Term]
id: GO:0002116
name: semaphorin receptor complex
namespace: cellular_component
def: "A stable binary complex of a neurophilin and a plexin, together forming a functional semaphorin receptor." [GOC:hjd, PMID:10934324, PMID:12367632, PMID:12613544]
synonym: "plexin-neurophilin complex" EXACT []
is_a: GO:0043235 ! receptor complex

[Term]
id: GO:0002117
name: amphibian larval development
namespace: biological_process
def: "The process whose specific outcome is the progression of the amphibian larva over time, from its formation to the mature structure. Amphibian larvae, sometimes called pollywogs or tadpoles, hatch from eggs and begin to grow limbs and other adult physical features at various times, depending on the species, before they metamorphose into the adult form." [GOC:bf, GOC:go_curators, http://www.livingunderworld.org/biology/]
is_a: GO:0002164 ! larval development

[Term]
id: GO:0002118
name: aggressive behavior
namespace: biological_process
def: "A behavioral interaction between organisms in which one organism has the intention of inflicting physical damage on another individual." [GOC:hjd]
synonym: "aggression" EXACT []
xref: Wikipedia:Aggression
is_a: GO:0051705 ! multi-organism behavior

[Term]
id: GO:0002119
name: nematode larval development
namespace: biological_process
def: "The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew." [GOC:ems, GOC:kmv]
is_a: GO:0002164 ! larval development

[Term]
id: GO:0002120
name: predatory behavior
namespace: biological_process
def: "Aggressive behavior involving attack on prey by a predator." [GOC:hjd]
synonym: "predatory aggression" EXACT []
synonym: "predatory aggressive behavior" EXACT []
is_a: GO:0002118 ! aggressive behavior
is_a: GO:0044366 ! feeding on or from other organism

[Term]
id: GO:0002121
name: inter-male aggressive behavior
namespace: biological_process
def: "Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd]
synonym: "inter-male aggression" EXACT []
is_a: GO:0002118 ! aggressive behavior

[Term]
id: GO:0002122
name: fear-induced aggressive behavior
namespace: biological_process
def: "Aggressive behavior associated with attempts to flee from a threat." [GOC:hjd]
synonym: "fear-induced aggression" EXACT []
is_a: GO:0002118 ! aggressive behavior

[Term]
id: GO:0002123
name: irritable aggressive behavior
namespace: biological_process
def: "Aggressive behavior induced by frustration and directed against an available target." [GOC:hjd]
synonym: "irritable aggression" EXACT []
is_a: GO:0002118 ! aggressive behavior

[Term]
id: GO:0002124
name: territorial aggressive behavior
namespace: biological_process
def: "Aggressive behavior performed in defence of a fixed area against intruders, typically conspecifics." [GOC:hjd]
synonym: "territorial aggression" EXACT []
is_a: GO:0002118 ! aggressive behavior

[Term]
id: GO:0002125
name: maternal aggressive behavior
namespace: biological_process
def: "Aggressive behavior of a female to protect her offspring from a threat." [GOC:hjd]
comment: Paternal aggression also exists. Serves to protect the offspring from intruders.
synonym: "maternal aggression" EXACT []
is_a: GO:0002118 ! aggressive behavior

[Term]
id: GO:0002126
name: instrumental aggressive behavior
namespace: biological_process
def: "Aggressive behavior directed towards obtaining some goal, considered to be a learned response to a situation." [GOC:hjd]
synonym: "instrumental aggression" EXACT []
is_a: GO:0002118 ! aggressive behavior

[Term]
id: GO:0002127
name: wobble base cytosine methylation
namespace: biological_process
def: "The process in which the base of cytosine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the C5 position." [GOC:hjd, ISBN:155581073X]
synonym: "wobble position m5C biosynthesis" EXACT []
is_a: GO:0002101 ! tRNA wobble cytosine modification
is_a: GO:0002946 ! tRNA C5-cytosine methylation

[Term]
id: GO:0002128
name: tRNA nucleoside ribose methylation
namespace: biological_process
def: "The process that results in the modification of the sugar of a nucleoside in tRNA at the 2'O position." [GOC:hjd, ISBN:155581073X]
is_a: GO:0030488 ! tRNA methylation

[Term]
id: GO:0002129
name: wobble position guanine ribose methylation
namespace: biological_process
def: "The process in which the ribose of guanosine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position." [GOC:hjd, ISBN:155581073X]
is_a: GO:0002130 ! wobble position ribose methylation
is_a: GO:0002938 ! tRNA guanine ribose methylation

[Term]
id: GO:0002130
name: wobble position ribose methylation
namespace: biological_process
def: "The process in which the ribose base of the nucleotide at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'O position." [GOC:hjd, ISBN:155581073X]
is_a: GO:0002128 ! tRNA nucleoside ribose methylation

[Term]
id: GO:0002131
name: wobble position cytosine ribose methylation
namespace: biological_process
def: "The process in which the ribose of cytidine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position." [GOC:hjd, ISBN:155581073X]
is_a: GO:0002130 ! wobble position ribose methylation

[Term]
id: GO:0002132
name: wobble position uridine ribose methylation
namespace: biological_process
def: "The process in which the ribose of uridine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position." [GOC:hjd, ISBN:155581073X]
is_a: GO:0002130 ! wobble position ribose methylation

[Term]
id: GO:0002133
name: polycystin complex
namespace: cellular_component
def: "A stable heterodimeric complex composed of polycystin-1 and polycystin-2." [GOC:hjd, PMID:11901144]
comment: Different forms of the complex differing in type of N-glycosylation of polycystin-1 can exist (endoglycosidase sensitive and endoglycosidase resistant).
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0002134
name: UTP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with UTP, uridine 5'-triphosphate." [GOC:hjd, ISBN:0198506732]
is_a: GO:0032551 ! pyrimidine ribonucleoside binding
is_a: GO:0032557 ! pyrimidine ribonucleotide binding
is_a: GO:0043168 ! anion binding

[Term]
id: GO:0002135
name: CTP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with CTP, cytidine 5'-triphosphate." [GOC:hjd, ISBN:0124020607]
is_a: GO:0032551 ! pyrimidine ribonucleoside binding
is_a: GO:0032557 ! pyrimidine ribonucleotide binding
is_a: GO:0043168 ! anion binding

[Term]
id: GO:0002136
name: wobble base lysidine biosynthesis
namespace: biological_process
def: "The process in which the carbonyl of cytosine at position 34 of a tRNA is post-transcriptionally replaced by lysine." [PMID:15894617]
comment: Exclusively located at the anticodon wobble position (i.e., position 34) of eubacterial and some organellar tRNAIle2. This modification converts the codon specificity from AUG to AUA, and it also converts the aminoacylation specificity of the tRNA from methionine to isoleucine. Requires ATP.
is_a: GO:0002101 ! tRNA wobble cytosine modification

[Term]
id: GO:0002138
name: retinoic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the biosynthesis of retinoic acid, one of the three components that makes up vitamin A." [GOC:hjd]
synonym: "retinoic acid anabolic process" EXACT []
is_a: GO:0016102 ! diterpenoid biosynthetic process
is_a: GO:0042573 ! retinoic acid metabolic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
created_by: hjd
creation_date: 2009-05-01T10:53:24Z

[Term]
id: GO:0002139
name: stereocilia coupling link
namespace: cellular_component
def: "A structure involved in coupling stereocilia to one another in sensory hair cells There are four morphologically distinct types: tip links, horizontal top connectors, shaft connectors and ankle links. Tip links and horizontal top connectors are the only inter-stereocilia links associated with mature cochlea, whereas ankle links appear during development of the auditory hair bundle." [PMID:16775142]
is_a: GO:0097458 ! neuron part
relationship: part_of GO:0032421 ! stereocilium bundle
created_by: hjd
creation_date: 2009-05-06T10:25:38Z

[Term]
id: GO:0002140
name: stereocilia tip link
namespace: cellular_component
def: "A stereocilia link that is formed by a fine filament running more or less vertically upward from the tip of each shorter stereocilium to attach at a higher point on its adjacent taller neighbor. Tilting the bundle puts tension on the filaments, which pull on mechanically gated ion channels in the membrane of the stereocilia." [PMID:1108787]
is_a: GO:0002139 ! stereocilia coupling link
created_by: hjd
creation_date: 2009-05-06T10:28:10Z

[Term]
id: GO:0002141
name: stereocilia ankle link
namespace: cellular_component
def: "A stereocilia coupling link that is composed of a fine filament present in developing stereocilia that couples the bases of individual stereocilia to one another. They are not present in mature stereocilia." [PMID:17567809]
is_a: GO:0002139 ! stereocilia coupling link
created_by: hjd
creation_date: 2009-05-06T10:31:56Z

[Term]
id: GO:0002142
name: stereocilia ankle link complex
namespace: cellular_component
def: "A complex of proteins that connect growing stereocilia in developing cochlear hair cells, composed of Vlgr1, usherin, vezatin, and whirlin." [PMID:16775142]
is_a: GO:0043234 ! protein complex
is_a: GO:0097458 ! neuron part
relationship: part_of GO:0002141 ! stereocilia ankle link
created_by: hjd
creation_date: 2009-05-06T10:33:57Z

[Term]
id: GO:0002143
name: tRNA wobble position uridine thiolation
namespace: biological_process
def: "The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps." [PMID:16871210]
comment: In E. coli, the first step of the reaction is reductive elimination of sulfur from L-cysteine by IscS cysteine desulfurase to form an enzyme-bound cysteine-persulfide intermediate. Then, five essential gene products, TusA, TusB, TusC, TusD and TusE, mediate a sulfur relay that delivers the terminal sulfur of persulfide from IscS to MnmA12. The last protein, MnmA catalyzes the transfer of the sulfur from IscS to an ATP activated U34 of the tRNA.
synonym: "tRNA wobble uridine thiolation" EXACT [GOC:mah]
synonym: "wobble position s2U biosynthesis" EXACT []
is_a: GO:0002098 ! tRNA wobble uridine modification
is_a: GO:0034227 ! tRNA thio-modification
created_by: hjd
creation_date: 2009-05-06T05:05:40Z

[Term]
id: GO:0002144
name: cytosolic tRNA wobble base thiouridylase complex
namespace: cellular_component
def: "A complex of two proteins involved in the thiolation of U34 in glutamate, lysine, and glutamine tRNAs of eukaryotes." [PMID:18391219]
synonym: "Cut1-Cut2 complex" NARROW []
synonym: "tRNA thiouridylase" BROAD []
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part
created_by: hjd
creation_date: 2009-05-08T02:32:55Z

[Term]
id: GO:0002145
name: 4-amino-5-hydroxymethyl-2-methylpyrimidine diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate + H2O = hydroxymethylpyrimidine phosphate + phosphate + H(+)." [MetaCyc:RXN0-3543]
synonym: "HMP-PP diphosphatase" EXACT []
synonym: "HMP-PP pyrophosphatase" EXACT []
xref: MetaCyc:RXN0-3543
is_a: GO:0016462 ! pyrophosphatase activity
created_by: hjd
creation_date: 2009-06-10T11:21:35Z

[Term]
id: GO:0002146
name: steroid hormone receptor import into nucleus
namespace: biological_process
def: "The directed movement of a steroid hormone receptor into the nucleus." [GOC:hjd]
comment: Note that 'translocation' is sometimes used in the literature to refer to the entire process of protein import into the nucleus, but in GO refers specifically to the step in which a cargo-carrier protein complex moves through the nuclear pore complex.
synonym: "steroid hormone receptor nuclear translocation" NARROW [GOC:mah]
is_a: GO:0006606 ! protein import into nucleus
created_by: hjd
creation_date: 2009-07-09T02:34:42Z

[Term]
id: GO:0002147
name: glucocorticoid receptor import into nucleus
namespace: biological_process
def: "The directed movement of a glucocorticoid receptor into the nucleus." [GOC:hjd]
synonym: "glucocorticoid receptor nuclear translocation" NARROW [GOC:mah]
is_a: GO:0002146 ! steroid hormone receptor import into nucleus
relationship: part_of GO:0042921 ! glucocorticoid receptor signaling pathway
created_by: hjd
creation_date: 2009-07-09T02:36:09Z

[Term]
id: GO:0002148
name: hypochlorous acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving hypochlorous acid." [GOC:add, PMID:176150, PMIG:10085024]
synonym: "HClO metabolic process" EXACT []
synonym: "HOCl metabolic process" EXACT []
synonym: "hypochlorite metabolic process" RELATED []
synonym: "hypochlorous acid metabolism" EXACT []
is_a: GO:0043436 ! oxoacid metabolic process
is_a: GO:0072593 ! reactive oxygen species metabolic process
created_by: hjd
creation_date: 2009-10-13T10:27:48Z

[Term]
id: GO:0002149
name: hypochlorous acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of hypochlorous acid." [GOC:add, PMID:10085024, PMID:176150]
comment: Note that this reaction is catalyzed by myeloperoxidase in neutrophils.
synonym: "HClO biosynthetic process" EXACT []
synonym: "HOCl biosynthetic process" EXACT []
synonym: "hypochlorite biosynthetic process" RELATED []
synonym: "hypochlorous acid biosynthesis" EXACT []
is_a: GO:0002148 ! hypochlorous acid metabolic process
is_a: GO:0044283 ! small molecule biosynthetic process
is_a: GO:1903409 ! reactive oxygen species biosynthetic process
created_by: hjd
creation_date: 2009-10-13T10:32:35Z

[Term]
id: GO:0002150
name: hypochlorous acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of hypochlorous acid." [GOC:add]
synonym: "HClO catabolic process" EXACT []
synonym: "HOCl catabolic process" EXACT []
synonym: "hypochlorite catabolic process" RELATED []
synonym: "hypochlorous acid catabolism" EXACT []
is_a: GO:0002148 ! hypochlorous acid metabolic process
is_a: GO:0044282 ! small molecule catabolic process
created_by: hjd
creation_date: 2009-10-13T10:36:09Z

[Term]
id: GO:0002151
name: G-quadruplex RNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with G-quadruplex RNA structures, in which groups of four guanines adopt a flat, cyclic hydrogen-bonding arrangement known as a guanine tetrad." [PMID:18294969, PMID:18568163, PMID:19330720]
comment: The structures of RNA and DNA G quartets differ regarding sugar conformation so that a protein binding to the RNA structure might not bind to the DNA structure.
synonym: "G quadruplex binding" EXACT [GOC:mah]
synonym: "G quartet binding" BROAD [GOC:hjd]
synonym: "G quartet RNA binding" EXACT [GOC:hjd]
synonym: "G-quartet binding" BROAD [GOC:mah]
is_a: GO:0003723 ! RNA binding
created_by: hjd
creation_date: 2009-10-22T01:38:02Z

[Term]
id: GO:0002152
name: bile acid conjugation
namespace: biological_process
def: "The process in which bile acids are covalently linked to taurine or glycine." [PMID:1094911, PMID:708413]
comment: The bile acid is first activated using CoA by cholate-CoA ligase activity(GO:0047747), then conjugated to taurine or glycine by glycine N-choloyltransferase activity (GO:0047963; appears to use either glycine or taurine).
is_a: GO:0008206 ! bile acid metabolic process
created_by: hjd
creation_date: 2009-10-29T01:41:51Z

[Term]
id: GO:0002153
name: steroid receptor RNA activator RNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the steroid receptor RNA activator RNA (SRA). SRA enhances steroid hormone receptor transcriptional activity as an RNA transcript by an indirect mechanism that does not involve SRA-steroid receptor binding." [GOC:vw, PMID:10199399, PMID:15180993]
comment: Note: there is also evidence that the RNA itself may code a protein (solution structure of mouse steroid receptor RNA activator 1 (SRA1) protein submitted to PDB by Riken).
synonym: "SRA binding" EXACT []
is_a: GO:0003727 ! single-stranded RNA binding
created_by: hjd
creation_date: 2009-11-16T02:18:55Z

[Term]
id: GO:0002154
name: thyroid hormone mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals mediated by the detection of a thyroid hormone." [GOC:hjd]
synonym: "thyroid hormone mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0009755 ! hormone-mediated signaling pathway
is_a: GO:0030522 ! intracellular receptor signaling pathway
created_by: hjd
creation_date: 2009-11-19T12:36:29Z

[Term]
id: GO:0002155
name: regulation of thyroid hormone mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a thyroid hormone mediated signaling pathway." [GOC:hjd]
synonym: "regulation of thyroid hormone mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0009966 ! regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002154 ! thyroid hormone mediated signaling pathway
relationship: regulates GO:0002154 ! thyroid hormone mediated signaling pathway
created_by: hjd
creation_date: 2009-11-19T12:37:46Z

[Term]
id: GO:0002156
name: negative regulation of thyroid hormone mediated signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of thyroid hormone mediated signaling pathway." [GOC:hjd]
synonym: "negative regulation of thyroid hormone mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0002155 ! regulation of thyroid hormone mediated signaling pathway
is_a: GO:0009968 ! negative regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002154 ! thyroid hormone mediated signaling pathway
relationship: negatively_regulates GO:0002154 ! thyroid hormone mediated signaling pathway
created_by: hjd
creation_date: 2009-11-19T12:41:48Z

[Term]
id: GO:0002157
name: positive regulation of thyroid hormone mediated signaling pathway
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of thyroid hormone mediated signaling pathway." [GOC:hjd]
synonym: "positive regulation of thyroid hormone mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0002155 ! regulation of thyroid hormone mediated signaling pathway
is_a: GO:0009967 ! positive regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002154 ! thyroid hormone mediated signaling pathway
relationship: positively_regulates GO:0002154 ! thyroid hormone mediated signaling pathway
created_by: hjd
creation_date: 2009-11-19T12:42:57Z

[Term]
id: GO:0002158
name: osteoclast proliferation
namespace: biological_process
def: "The multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes." [CL:0000092, GOC:hjd]
is_a: GO:0070661 ! leukocyte proliferation
created_by: hjd
creation_date: 2010-02-03T01:50:37Z

[Term]
id: GO:0002159
name: desmosome assembly
namespace: biological_process
def: "A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm." [GOC:hjd, ISBN:0198506732]
comment: Desmosomes link two cells together; hemidesmosomes attach one cell to the extracellular matrix.
is_a: GO:0002934 ! desmosome organization
is_a: GO:0007043 ! cell-cell junction assembly
created_by: hjd
creation_date: 2010-02-09T10:46:30Z

[Term]
id: GO:0002160
name: desmosome maintenance
namespace: biological_process
def: "The maintenance of a desmosome. A desmosome is a patch-like intercellular junctions found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an interspace of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm." [GOC:hjd, ISBN:0198506732]
comment: Desmosomes link two cells together; hemidesmosomes attach one cell to the extracellular matrix.
is_a: GO:0002934 ! desmosome organization
is_a: GO:0045217 ! cell-cell junction maintenance
created_by: hjd
creation_date: 2010-02-09T10:50:59Z

[Term]
id: GO:0002161
name: aminoacyl-tRNA editing activity
namespace: molecular_function
def: "The hydrolysis of an incorrectly aminoacylated tRNA." [GOC:hjd, PMID:14663147, PMID:16087889]
synonym: "amino acid proofreading activity" RELATED []
synonym: "aminoacyl-tRNA hydrolysis activity" RELATED []
is_a: GO:0052689 ! carboxylic ester hydrolase activity
relationship: part_of GO:0006450 ! regulation of translational fidelity
created_by: hjd
creation_date: 2010-02-12T03:06:56Z

[Term]
id: GO:0002162
name: dystroglycan binding
namespace: molecular_function
alt_id: GO:0002163
alt_id: GO:0002166
def: "Interacting selectively and non-covalently with dystroglycan. Dystroglycan is glycoprotein found in non-muscle tissues as well as in muscle tissues, often in association with dystrophin. The native dystroglycan cleaved into two non-covalently associated subunits, alpha (N-terminal) and beta (C-terminal)." [GOC:hjd]
synonym: "alpha-dystroglycan binding" NARROW []
synonym: "beta-dystroglycan binding" NARROW []
is_a: GO:0001948 ! glycoprotein binding
created_by: hjd
creation_date: 2010-02-22T02:17:58Z

[Term]
id: GO:0002164
name: larval development
namespace: biological_process
def: "The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. The larva is the early, immature form of an that at birth or hatching is fundamentally unlike its parent and must metamorphose before assuming the adult characters." [GOC:jid, ISBN:0877795088]
is_a: GO:0007275 ! multicellular organism development
is_a: GO:0009791 ! post-embryonic development

[Term]
id: GO:0002165
name: instar larval or pupal development
namespace: biological_process
def: "The process whose specific outcome is the progression of the instar larva or pupa over time, from its formation to the mature structure. An example of this process is found in Drosophila melanogaster." [GOC:jid, GOC:mtg_sensu]
is_a: GO:0007275 ! multicellular organism development
is_a: GO:0009791 ! post-embryonic development

[Term]
id: GO:0002167
name: VRK3/VHR/ERK complex
namespace: cellular_component
def: "A ternary complex consisting of VRK3, VHR (Dusp3), and ERK1 (Mapk3) existing in neuronal cells, and is involved in regulation of the ERK signaling pathway." [GOC:hjd, PMID:16845380]
is_a: GO:0043234 ! protein complex
created_by: hjd
creation_date: 2010-03-04T01:15:05Z

[Term]
id: GO:0002168
name: instar larval development
namespace: biological_process
def: "The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. This begins with the newly hatched first-instar larva, through its maturation to the end of the last larval stage. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
is_a: GO:0002164 ! larval development
is_a: GO:0002165 ! instar larval or pupal development

[Term]
id: GO:0002169
name: 3-methylcrotonyl-CoA carboxylase complex, mitochondrial
namespace: cellular_component
def: "A heterodimeric complex having 3-methylcrotonyl-CoA carboxylase activity. The alpha subunit has a covalently bound biotin essential for the ATP-dependent carboxylation. The beta subunit possess carboxyltransferase activity which presumably is essential for binding to 3-methylcrotonyl-CoA." [GOC:hjd, PMID:15868465]
is_a: GO:0098798 ! mitochondrial protein complex
is_a: GO:1902494 ! catalytic complex
relationship: part_of GO:0005739 ! mitochondrion
created_by: hjd
creation_date: 2010-03-15T04:58:08Z

[Term]
id: GO:0002170
name: high-affinity IgA receptor activity
namespace: molecular_function
def: "Combining with high affinity with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:hjd, GOC:signaling]
synonym: "high affinity IgA receptor activity" EXACT []
is_a: GO:0019766 ! IgA receptor activity
created_by: hjd
creation_date: 2010-05-06T05:00:11Z

[Term]
id: GO:0002171
name: low-affinity IgA receptor activity
namespace: molecular_function
def: "Combining with low affinity with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:hjd, GOC:signaling]
synonym: "low affinity IgA receptor activity" EXACT []
is_a: GO:0019766 ! IgA receptor activity
created_by: hjd
creation_date: 2010-05-06T05:01:41Z

[Term]
id: GO:0002172
name: high-affinity IgM receptor activity
namespace: molecular_function
def: "Combining with high affinity with an immunoglobulin of an IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:hjd, GOC:signaling]
synonym: "high affinity IgM receptor activity" EXACT []
is_a: GO:0001793 ! IgM receptor activity
created_by: hjd
creation_date: 2010-05-06T05:03:26Z

[Term]
id: GO:0002173
name: low-affinity IgM receptor activity
namespace: molecular_function
def: "Combining with low affinity with an immunoglobulin of an IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:hjd, GOC:signaling]
synonym: "low affinity IgM receptor activity" EXACT []
is_a: GO:0001793 ! IgM receptor activity
created_by: hjd
creation_date: 2010-05-06T05:04:24Z

[Term]
id: GO:0002174
name: mammary stem cell proliferation
namespace: biological_process
def: "The expansion of a mammary stem cell population by cell division. Mammary stem cells are a source of cells for growth of the mammary gland during puberty and gestation. These cells can give rise to both the luminal and myoepithelial cell types of the gland, and can regenerate the entire organ." [PMID:15987436]
is_a: GO:0008283 ! cell proliferation
relationship: part_of GO:0030879 ! mammary gland development
created_by: hjd
creation_date: 2010-09-14T01:19:45Z

[Term]
id: GO:0002175
name: protein localization to paranode region of axon
namespace: biological_process
def: "A cellular protein localization process in which a protein is transported to, or maintained at, the paranode region of an axon." [PMID:18803321]
synonym: "protein localisation to paranode region of axon" EXACT [GOC:mah]
is_a: GO:0034613 ! cellular protein localization
is_a: GO:0099612 ! protein localization to axon
created_by: hjd
creation_date: 2010-11-15T10:28:20Z

[Term]
id: GO:0002176
name: male germ cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of male germ cells, resulting in the expansion of a cell population." [GOC:hjd]
is_a: GO:0036093 ! germ cell proliferation
created_by: hjd
creation_date: 2010-11-18T02:35:14Z

[Term]
id: GO:0002177
name: manchette
namespace: cellular_component
def: "A conical shaped array of microtubules that completely covers the nucleus of a spermatid, thought to be involved in sperm head elongation." [PMID:15018141]
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0015630 ! microtubule cytoskeleton
created_by: hjd
creation_date: 2010-12-01T02:31:43Z

[Term]
id: GO:0002178
name: palmitoyltransferase complex
namespace: cellular_component
def: "A protein complex with palmitoyltransferase activity." [GOC:hjd]
is_a: GO:1990234 ! transferase complex
created_by: hjd
creation_date: 2010-12-03T10:49:17Z

[Term]
id: GO:0002179
name: homodimeric serine palmitoyltransferase complex
namespace: cellular_component
def: "A homodimeric complex which transfers a palmitoyl group onto serine, forming 3-dehydro-D-sphinganine." [GOC:hjd]
comment: This complex occurs primarily in bacteria.
is_a: GO:0017059 ! serine C-palmitoyltransferase complex
created_by: hjd
creation_date: 2010-12-03T10:50:59Z

[Term]
id: GO:0002180
name: 5-lipoxygenase complex
namespace: cellular_component
def: "An nuclear membrane protein complex having arachidonate 5-lipoxygenase activity." [PMID:19075240]
is_a: GO:0044453 ! nuclear membrane part
is_a: GO:0098796 ! membrane protein complex
is_a: GO:1990204 ! oxidoreductase complex
created_by: hjd
creation_date: 2011-06-09T01:05:53Z

[Term]
id: GO:0002181
name: cytoplasmic translation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd]
comment: Note that this term applies to translation performed by cytoplasmic ribosomes, which is distinct from translation performed by organellar ribosomes. For mitochondrial translation, consider GO:0032543 'mitochondrial translation' or its child terms.
subset: goslim_pombe
subset: goslim_yeast
is_a: GO:0006412 ! translation
created_by: hjd
creation_date: 2011-06-09T03:11:53Z

[Term]
id: GO:0002182
name: cytoplasmic translational elongation
namespace: biological_process
def: "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in the cytoplasm." [GOC:hjd]
is_a: GO:0006414 ! translational elongation
intersection_of: GO:0006414 ! translational elongation
intersection_of: part_of GO:0002181 ! cytoplasmic translation
relationship: part_of GO:0002181 ! cytoplasmic translation
created_by: hjd
creation_date: 2011-06-09T03:14:42Z

[Term]
id: GO:0002183
name: cytoplasmic translational initiation
namespace: biological_process
def: "The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [GOC:hjd]
is_a: GO:0006413 ! translational initiation
intersection_of: GO:0006413 ! translational initiation
intersection_of: part_of GO:0002181 ! cytoplasmic translation
relationship: part_of GO:0002181 ! cytoplasmic translation
created_by: hjd
creation_date: 2011-06-09T03:15:48Z

[Term]
id: GO:0002184
name: cytoplasmic translational termination
namespace: biological_process
def: "The process resulting in the release of a polypeptide chain from the ribosome in the cytoplasm, usually in response to a termination codon." [GOC:hjd]
is_a: GO:0006415 ! translational termination
intersection_of: GO:0006415 ! translational termination
intersection_of: occurs_in GO:0005829 ! cytosol
relationship: occurs_in GO:0005829 ! cytosol
relationship: part_of GO:0002181 ! cytoplasmic translation
created_by: hjd
creation_date: 2011-06-09T03:17:13Z

[Term]
id: GO:0002185
name: creatine kinase complex
namespace: cellular_component
def: "A protein complex having creatine kinase activity." [GOC:hjd]
is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups
created_by: hjd
creation_date: 2011-06-14T02:12:19Z

[Term]
id: GO:0002186
name: cytosolic creatine kinase complex
namespace: cellular_component
def: "A dimeric protein complex having creatine kinase activity." [PMID:173175]
is_a: GO:0002185 ! creatine kinase complex
is_a: GO:0044445 ! cytosolic part
intersection_of: GO:0002185 ! creatine kinase complex
intersection_of: part_of GO:0005829 ! cytosol
relationship: part_of GO:0005829 ! cytosol
created_by: hjd
creation_date: 2011-06-14T02:14:16Z

[Term]
id: GO:0002187
name: mitochondrial creatine kinase complex
namespace: cellular_component
def: "An octomeric protein complex having creatine kinase activity." [PMID:16236486]
is_a: GO:0002185 ! creatine kinase complex
is_a: GO:0098798 ! mitochondrial protein complex
intersection_of: GO:0002185 ! creatine kinase complex
intersection_of: part_of GO:0005739 ! mitochondrion
relationship: part_of GO:0005739 ! mitochondrion
created_by: hjd
creation_date: 2011-06-14T02:15:29Z

[Term]
id: GO:0002188
name: translation reinitiation
namespace: biological_process
def: "A gene-specific translational control mechanism where the small ribosomal subunit remains attached to the mRNA following termination of translation, then resumes scanning on the same mRNA molecule and initiates again at a downstream start site. Reinitiation depends on de novo recruitment of the ternary complex that is required to recognize the next AUG codon." [PMID:18056426, PMID:18765792]
is_a: GO:0002183 ! cytoplasmic translational initiation
created_by: hjd
creation_date: 2011-06-22T12:31:13Z

[Term]
id: GO:0002189
name: ribose phosphate diphosphokinase complex
namespace: cellular_component
def: "A protein complex having ribose phosphate diphosphokinase activity." [GO:hjd, PMID:9348095]
comment: In mammals, the complex consists of two non-identical catalytic subunits and two non-identical regulatory subunits.
synonym: "phosphoribosylpyrophosphate synthetase complex" EXACT [PMID:9348095]
synonym: "PRPP synthetase complex" EXACT [PMID:9348095]
is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups
created_by: hjd
creation_date: 2011-06-27T02:49:33Z

[Term]
id: GO:0002190
name: cap-independent translational initiation
namespace: biological_process
def: "The process where translation initiation recruits the 40S ribosomal subunits in a Cap and 5' end independent fashion before an AUG codon is encountered in an appropriate sequence context to initiate mRNA translation." [PMID:17284590]
is_a: GO:0002183 ! cytoplasmic translational initiation
created_by: hjd
creation_date: 2011-08-11T02:16:05Z

[Term]
id: GO:0002191
name: cap-dependent translational initiation
namespace: biological_process
def: "The process where the \"Cap structure\" (composed of a 7- methylguanosine (m7G) group and associated cap-binding proteins) located at the 5' end of an mRNA molecule, which serves as a \"molecular tag\" that marks the spot where the 40S ribosomal subunit is recruited and will then scan in a 5' to 3' direction until an AUG codon is encountered in an appropriate sequence context to initiate mRNA translation." [PMID:17284590, PMID:19604130]
is_a: GO:0002183 ! cytoplasmic translational initiation
created_by: hjd
creation_date: 2011-08-11T02:20:24Z

[Term]
id: GO:0002192
name: IRES-dependent translational initiation
namespace: biological_process
def: "The process where translation initiation recruits the 40S ribosomal subunits via an internal ribosome entry segment (IRES) before an AUG codon is encountered in an appropriate sequence context to initiate mRNA translation." [PMID:17284590]
is_a: GO:0002190 ! cap-independent translational initiation
created_by: hjd
creation_date: 2011-08-11T02:32:45Z

[Term]
id: GO:0002193
name: MAML1-RBP-Jkappa- ICN1 complex
namespace: cellular_component
def: "A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-1 (MAML1); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [CORUM:2949, PMID:16510869]
synonym: "MAML1-CSL-ICN1" EXACT []
synonym: "MAML1-CSL-Notch1 complex" EXACT []
synonym: "MAML1-RBP-Jkappa-Notch1 complex" EXACT []
is_a: GO:0043234 ! protein complex
created_by: hjd
creation_date: 2011-08-11T04:08:18Z

[Term]
id: GO:0002194
name: hepatocyte cell migration
namespace: biological_process
def: "The orderly movement of a hepatocyte during the development of the liver. Hepatocytes emerge from the hepatic epithelium, populating the septum transversum and lateral mesenchymal areas of the hepatic lobes." [CL:0000182, PMID:9794819]
is_a: GO:0016477 ! cell migration
created_by: hjd
creation_date: 2011-08-30T04:27:39Z

[Term]
id: GO:0002195
name: 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine-tRNA biosynthesis
namespace: biological_process
def: "The chemical reactions and pathways involved in the biosynthesis of 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine (ms2io6A), a modified nucleoside present in position 37 (adjacent to and 3' of the anticodon) of tRNAs." [UniPathway:UPA00729]
comment: In Salmonella typhimurium, 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine (ms2io6A; also referred to as 2-methylthio cis-ribozeatin) is found in tRNA, most likely in the species that have ms2i6A in E. coli.
is_a: GO:0006400 ! tRNA modification
created_by: hjd
creation_date: 2011-08-31T02:20:06Z

[Term]
id: GO:0002196
name: Ser-tRNA(Ala) hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of misacylated Ser-tRNA(Ala)." [GOC:hjd, PMID:21285375]
is_a: GO:0002161 ! aminoacyl-tRNA editing activity
created_by: hjd
creation_date: 2011-09-30T02:18:50Z

[Term]
id: GO:0002197
name: xanthine dehydrogenase complex
namespace: cellular_component
def: "A homodimeric protein complex having xanthine dehydrogenase activity." [GOC:hjd, PMID:8224915]
is_a: GO:1990204 ! oxidoreductase complex
created_by: hjd
creation_date: 2011-10-03T03:55:57Z

[Term]
id: GO:0002198
name: obsolete S/G2 transition of mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. The transition from a cell in the S phase to the G2 phase." [GOC:hjd, GOC:mtg_cell_cycle, PMID:15161931]
comment: This term was made obsolete because it does not refer to a real biological process.
synonym: "S/G2 transition of mitotic cell cycle" EXACT []
is_obsolete: true
created_by: hjd
creation_date: 2011-11-02T10:36:58Z

[Term]
id: GO:0002199
name: zona pellucida receptor complex
namespace: cellular_component
def: "A multisubunit complex comprising the chaperonin-containing T-complex and several other components involved in mediating sperm-oocyte Interaction." [GOC:hjd, PMID:21880732]
synonym: "sperm protein complex I" RELATED []
is_a: GO:0043234 ! protein complex
relationship: has_part GO:0005832 ! chaperonin-containing T-complex
created_by: hjd
creation_date: 2011-12-23T01:33:23Z

[Term]
id: GO:0002200
name: somatic diversification of immune receptors
namespace: biological_process
def: "The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences." [GOC:add, ISBN:0781735149, PMID:16102575, PMID:16166509]
comment: Note that this process covers somatic recombination, gene conversion, hypermutation, N-region addition, and alternate splicing processes of immune receptor diversification.
is_a: GO:0002376 ! immune system process
relationship: part_of GO:0002520 ! immune system development

[Term]
id: GO:0002201
name: somatic diversification of DSCAM-based immune receptors
namespace: biological_process
def: "The somatic process that results in the generation of sequence diversity of the DSCAM-based immune receptors of insects." [GOC:add, PMID:16261174]
comment: Note that this type of immune receptor may not be limited to insects.
is_a: GO:0002200 ! somatic diversification of immune receptors

[Term]
id: GO:0002202
name: somatic diversification of variable lymphocyte receptors of jawless fish
namespace: biological_process
def: "The somatic process that results in the generation of sequence diversity of the variable lymphocyte receptors (VLR) of jawless fish." [GOC:add, PMID:16373579]
comment: Note that jawless fish refers to both lampreys (Petremyzontidae, ncbi_taxonomy_id:7746) and hagfish (Myxinidae, ncbi_taxonomy_id:7762).
is_a: GO:0002200 ! somatic diversification of immune receptors

[Term]
id: GO:0002203
name: proteolysis by cytosolic proteases associated with antigen processing and presentation
namespace: biological_process
def: "The hydrolysis of a peptide bond or bonds within a protein by cytosolic resident proteases during antigen processing and presentation." [GOC:add, ISBN:0781735149, PMID:15224092, PMID:15771591]
comment: Note that a separate term covers proteolysis by the proteasome complex (proteasomal proteolysis associated with antigen processing and presentation ; GO:0002497).
is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation

[Term]
id: GO:0002204
name: somatic recombination of immunoglobulin genes involved in immune response
namespace: biological_process
def: "The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of and contributing to an immune response." [GOC:add, ISBN:0781735149]
synonym: "somatic recombination of antibody genes during immune response" RELATED []
synonym: "somatic recombination of immunoglobulin genes during immune response" RELATED [GOC:dph]
is_a: GO:0002208 ! somatic diversification of immunoglobulins involved in immune response
is_a: GO:0016447 ! somatic recombination of immunoglobulin gene segments

[Term]
id: GO:0002205
name: somatic hypermutation of immunoglobulin genes involved in immune response
namespace: biological_process
def: "Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins following the induction of and contributing to an immune response." [GOC:add, ISBN:0781735149, PMID:11205333, PMID:14991701]
synonym: "somatic hypermutation of antibody genes during immune response" RELATED []
synonym: "somatic hypermutation of immunoglobulin genes during immune response" RELATED [GOC:dph]
is_a: GO:0002208 ! somatic diversification of immunoglobulins involved in immune response
is_a: GO:0016446 ! somatic hypermutation of immunoglobulin genes
relationship: part_of GO:0002344 ! B cell affinity maturation

[Term]
id: GO:0002206
name: gene conversion of immunoglobulin genes
namespace: biological_process
def: "The somatic process in which immunoglobulin genes are diversified through the mechanism of gene conversion." [GOC:add, PMID:14991701]
synonym: "gene conversion of antibody genes" EXACT []
is_a: GO:0002565 ! somatic diversification of immune receptors via gene conversion
is_a: GO:0016445 ! somatic diversification of immunoglobulins
is_a: GO:0035822 ! gene conversion

[Term]
id: GO:0002207
name: gene conversion of immunoglobulin genes involved in immune response
namespace: biological_process
def: "The somatic process in which immunoglobulin genes are diversified through the mechanism of gene conversion following the induction of and contributing to an immune response." [GOC:add, PMID:14991701]
synonym: "gene conversion of antibody genes during immune response" RELATED []
synonym: "gene conversion of immunoglobulin genes during immune response" RELATED [GOC:dph]
is_a: GO:0002206 ! gene conversion of immunoglobulin genes
is_a: GO:0002208 ! somatic diversification of immunoglobulins involved in immune response

[Term]
id: GO:0002208
name: somatic diversification of immunoglobulins involved in immune response
namespace: biological_process
def: "The somatic process that results in the generation of sequence diversity of immunoglobulins after induction, and contributes to an immune response." [GOC:add, ISBN:0781735149, PMID:14991701]
synonym: "somatic diversification of antibodies during immune response" RELATED []
synonym: "somatic diversification of immunoglobulins during immune response" RELATED [GOC:dph]
is_a: GO:0016445 ! somatic diversification of immunoglobulins
relationship: part_of GO:0002381 ! immunoglobulin production involved in immunoglobulin mediated immune response

[Term]
id: GO:0002209
name: behavioral defense response
namespace: biological_process
def: "A behavioral response seeking to protect an organism from an a perceived external threat to that organism." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
comment: This term was added by GO_REF:0000022.
synonym: "behavioural defense response" EXACT []
is_a: GO:0006952 ! defense response
is_a: GO:0007610 ! behavior

[Term]
id: GO:0002210
name: behavioral response to wounding
namespace: biological_process
def: "A behavioral response resulting from wounding." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
comment: This term was added by GO_REF:0000022.
synonym: "behavioural response to wounding" EXACT []
is_a: GO:0009611 ! response to wounding
is_a: GO:0044708 ! single-organism behavior

[Term]
id: GO:0002211
name: behavioral defense response to insect
namespace: biological_process
def: "A behavioral response seeking to protect an organism from an a perceived external threat from an insect or insects to that organism." [GOC:add]
synonym: "behavioural defense response to insect" EXACT []
is_a: GO:0002209 ! behavioral defense response
is_a: GO:0002213 ! defense response to insect
is_a: GO:0051705 ! multi-organism behavior

[Term]
id: GO:0002212
name: behavioral defense response to nematode
namespace: biological_process
def: "A behavioral response seeking to protect an organism from an a perceived external threat from a nematode or nematodes to that organism." [GOC:add, PMID:14506883]
synonym: "behavioural defense response to nematode" EXACT []
is_a: GO:0002209 ! behavioral defense response
is_a: GO:0002215 ! defense response to nematode
is_a: GO:0051705 ! multi-organism behavior

[Term]
id: GO:0002213
name: defense response to insect
namespace: biological_process
alt_id: GO:0002214
def: "A response to protect an organism from a directly detected or perceived external threat from an insect or insects to that organism." [GOC:add]
synonym: "physiological defense response to insect" EXACT []
is_a: GO:0009625 ! response to insect
is_a: GO:0098542 ! defense response to other organism

[Term]
id: GO:0002215
name: defense response to nematode
namespace: biological_process
alt_id: GO:0002216
def: "A response to protect an organism from a directly detected or perceived external threat from a nematode or nematodes, which results in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:add, PMID:11516579, PMID:14506883]
synonym: "physiological defense response to nematode" EXACT []
is_a: GO:0009624 ! response to nematode
is_a: GO:0098542 ! defense response to other organism

[Term]
id: GO:0002218
name: activation of innate immune response
namespace: biological_process
alt_id: GO:0002219
def: "Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, GOC:mtg_sensu, ISBN:0781735149, PMID:15199967, PMID:16177805]
comment: This term was added by GO_REF:0000022.
xref: Reactome:REACT_75835 "RLR (RIG-like receptor) mediated induction of IFN alpha/beta, Gallus gallus"
is_a: GO:0002253 ! activation of immune response
is_a: GO:0045089 ! positive regulation of innate immune response

[Term]
id: GO:0002220
name: innate immune response activating cell surface receptor signaling pathway
namespace: biological_process
def: "Any series of molecular signals leading to activation of the innate immune response generated as a consequence of binding to a cell surface receptor." [GOC:add, ISBN:0781735149, PMID:15199967]
synonym: "activation of innate immune response by cell surface receptor signaling pathway" EXACT []
synonym: "innate immune response activating cell surface receptor signalling pathway" EXACT []
is_a: GO:0002429 ! immune response-activating cell surface receptor signaling pathway
is_a: GO:0002758 ! innate immune response-activating signal transduction

[Term]
id: GO:0002221
name: pattern recognition receptor signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of a pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967]
synonym: "PAMP receptor signaling pathway" EXACT [ISBN:0781735149, PMID:15199967, PMID:15728447]
synonym: "pathogen receptor signaling pathway" EXACT [ISBN:0781735149, PMID:15199967, PMID:15728447]
synonym: "pathogen receptor signalling pathway" EXACT [ISBN:0781735149, PMID:15199967, PMID:15728447]
synonym: "PRR signaling pathway" EXACT [ISBN:0781735149, PMID:15199967, PMID:15728447]
is_a: GO:0002758 ! innate immune response-activating signal transduction

[Term]
id: GO:0002222
name: stimulatory killer cell immunoglobulin-like receptor signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to a killer cell immunoglobulin-like receptor capable of cellular activation." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
synonym: "stimulatory killer cell immunoglobulin-like receptor signalling pathway" EXACT []
synonym: "stimulatory KIR signaling pathway" EXACT [ISBN:0781735149]
is_a: GO:0002220 ! innate immune response activating cell surface receptor signaling pathway

[Term]
id: GO:0002223
name: stimulatory C-type lectin receptor signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to a C-type lectin receptor capable of cellular activation." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
synonym: "stimulatory C-type lectin receptor signalling pathway" EXACT []
synonym: "stimulatory Ly49 family receptor signaling pathway." NARROW [ISBN:0781735149]
is_a: GO:0002220 ! innate immune response activating cell surface receptor signaling pathway

[Term]
id: GO:0002224
name: toll-like receptor signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149, PMID:12467241, PMID:12524386, PMID:12855817, PMID:15585605, PMID:15728447]
comment: This term was added by GO_REF:0000022. Note that the vertebrate toll-like receptors, unlike the Drosophila Toll molecule, directly bind their ligands. The Drosophila Toll molecule requires the Sptzle factor to bind microbial ligands and then the receptor in order to initiate innate immune responses.
synonym: "TLR signaling pathway" EXACT [ISBN:0781735149]
synonym: "toll-like receptor signalling pathway" EXACT []
xref: Reactome:REACT_25035 "Innate immune response mediated by toll like receptors, Gallus gallus"
is_a: GO:0002221 ! pattern recognition receptor signaling pathway

[Term]
id: GO:0002225
name: positive regulation of antimicrobial peptide production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide production." [GOC:add, PMID:11807545]
synonym: "activation of antimicrobial peptide production" NARROW []
synonym: "antimicrobial peptide induction" EXACT []
synonym: "stimulation of antimicrobial peptide production" NARROW []
synonym: "up regulation of antimicrobial peptide production" EXACT []
synonym: "up-regulation of antimicrobial peptide production" EXACT []
synonym: "upregulation of antimicrobial peptide production" EXACT []
is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response
is_a: GO:0002760 ! positive regulation of antimicrobial humoral response
is_a: GO:0002784 ! regulation of antimicrobial peptide production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002775 ! antimicrobial peptide production
relationship: positively_regulates GO:0002775 ! antimicrobial peptide production

[Term]
id: GO:0002227
name: innate immune response in mucosa
namespace: biological_process
def: "Any process of the innate immune response that takes place in the mucosal tissues." [GOC:add, PMID:10719665, PMID:15971105]
is_a: GO:0002385 ! mucosal immune response
is_a: GO:0045087 ! innate immune response

[Term]
id: GO:0002228
name: natural killer cell mediated immunity
namespace: biological_process
def: "The promotion of an immune response by natural killer cells through direct recognition of target cells or through the release of cytokines." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
synonym: "NK cell mediated immunity" EXACT []
is_a: GO:0002449 ! lymphocyte mediated immunity
is_a: GO:0045087 ! innate immune response

[Term]
id: GO:0002229
name: defense response to oomycetes
namespace: biological_process
def: "Reactions triggered in response to the presence of oomycetes that act to protect the cell or organism." [GOC:add, PMID:16497589]
is_a: GO:0002239 ! response to oomycetes
is_a: GO:0098542 ! defense response to other organism

[Term]
id: GO:0002230
name: positive regulation of defense response to virus by host
namespace: biological_process
def: "Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication." [GOC:add, GOC:dph, GOC:tb, ISBN:0781735149]
synonym: "activation of antiviral response by host" NARROW []
synonym: "positive regulation of antiviral response by host" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of antiviral response by host" NARROW []
synonym: "up regulation of antiviral response by host" EXACT []
synonym: "up-regulation of antiviral response by host" EXACT []
synonym: "upregulation of antiviral response by host" EXACT []
is_a: GO:0050691 ! regulation of defense response to virus by host

[Term]
id: GO:0002231
name: detection of oomycetes
namespace: biological_process
def: "The series of events in which a stimulus from an oomycetes is received and converted into a molecular signal." [GOC:add, PMID:15922649]
is_a: GO:0002239 ! response to oomycetes
is_a: GO:0098543 ! detection of other organism

[Term]
id: GO:0002232
name: leukocyte chemotaxis involved in inflammatory response
namespace: biological_process
def: "The movement of an immune cell in response to an external stimulus contributing to an inflammatory response." [GOC:add, ISBN:0781735149]
synonym: "immune cell chemotaxis during inflammatory response" RELATED []
synonym: "leucocyte chemotaxis during inflammatory response" RELATED []
synonym: "leukocyte chemotaxis during inflammatory response" RELATED [GOC:dph]
is_a: GO:0002523 ! leukocyte migration involved in inflammatory response
is_a: GO:0030595 ! leukocyte chemotaxis
intersection_of: GO:0030595 ! leukocyte chemotaxis
intersection_of: part_of GO:0006954 ! inflammatory response
relationship: part_of GO:0006954 ! inflammatory response

[Term]
id: GO:0002233
name: leukocyte chemotaxis involved in immune response
namespace: biological_process
def: "The movement of an immune cell in response to an external stimulus a part of an immune response." [GOC:add, ISBN:0781735149]
synonym: "immune cell chemotaxis during immune response" EXACT []
synonym: "leucocyte chemotaxis during immune response" EXACT []
is_a: GO:0002522 ! leukocyte migration involved in immune response
is_a: GO:0030595 ! leukocyte chemotaxis
intersection_of: GO:0030595 ! leukocyte chemotaxis
intersection_of: part_of GO:0006955 ! immune response
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0002234
name: detection of endoplasmic reticulum overloading
namespace: biological_process
def: "The series of events in which a stimulus generated by the accumulation of normal or misfolded proteins in the endoplasmic reticulum is received and converted into a molecular signal." [GOC:add, PMID:10390516]
synonym: "detection of ER overloading" EXACT []
is_a: GO:0006983 ! ER overload response
is_a: GO:0009595 ! detection of biotic stimulus

[Term]
id: GO:0002235
name: detection of unfolded protein
namespace: biological_process
def: "The series of events in which an unfolded protein stimulus is received and converted into a molecular signal." [GOC:add, PMID:15226511, PMID:7765470]
is_a: GO:0006986 ! response to unfolded protein
is_a: GO:0009593 ! detection of chemical stimulus

[Term]
id: GO:0002236
name: detection of misfolded protein
namespace: biological_process
def: "The series of events in which a misfolded protein stimulus is received and converted into a molecular signal." [GOC:add, PMID:15226511]
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0051788 ! response to misfolded protein

[Term]
id: GO:0002237
name: response to molecule of bacterial origin
namespace: biological_process
def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin." [GOC:rl, GOC:sm]
synonym: "response to bacteria associated molecule" EXACT []
synonym: "response to bacterial associated molecule" EXACT []
synonym: "response to bacterium associated molecule" EXACT []
is_a: GO:0010033 ! response to organic substance
is_a: GO:0043207 ! response to external biotic stimulus
relationship: part_of GO:0009617 ! response to bacterium

[Term]
id: GO:0002238
name: response to molecule of fungal origin
namespace: biological_process
def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of fungal origin such as chito-octamer oligosaccharide." [GOC:rl, GOC:sm]
synonym: "response to fungus associated molecule" EXACT []
is_a: GO:0010033 ! response to organic substance
is_a: GO:0043207 ! response to external biotic stimulus
relationship: part_of GO:0009620 ! response to fungus

[Term]
id: GO:0002239
name: response to oomycetes
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from an oomycetes." [GOC:add, PMID:16497589]
is_a: GO:0051707 ! response to other organism

[Term]
id: GO:0002240
name: response to molecule of oomycetes origin
namespace: biological_process
def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of oomycetes origin." [GOC:rl, GOC:sm]
synonym: "response to oomycetes associated molecule" EXACT []
is_a: GO:0010033 ! response to organic substance
is_a: GO:0043207 ! response to external biotic stimulus
relationship: part_of GO:0002239 ! response to oomycetes

[Term]
id: GO:0002241
name: response to parasitic plant
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a parasitic plant." [GOC:add, PMID:16547862]
is_a: GO:0009608 ! response to symbiont

[Term]
id: GO:0002242
name: defense response to parasitic plant
namespace: biological_process
def: "Reactions triggered in response to the presence of a parasitic plant that act to protect an organism." [GOC:add]
is_a: GO:0002241 ! response to parasitic plant
is_a: GO:0098542 ! defense response to other organism

[Term]
id: GO:0002243
name: detection of parasitic plant
namespace: biological_process
def: "The series of events in which a stimulus from a parasitic plant is received and converted into a molecular signal." [GOC:add, PMID:16547862]
is_a: GO:0002241 ! response to parasitic plant
is_a: GO:0009602 ! detection of symbiont

[Term]
id: GO:0002244
name: hematopoietic progenitor cell differentiation
namespace: biological_process
def: "The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells." [GOC:add, GOC:rl, ISBN:0781735149, PMID:16551251]
synonym: "haematopoietic progenitor cell differentiation" EXACT []
synonym: "haemopoietic progenitor cell differentiation" EXACT []
synonym: "hemopoietic progenitor cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0030097 ! hemopoiesis

[Term]
id: GO:0002246
name: wound healing involved in inflammatory response
namespace: biological_process
def: "The series of events that restore integrity to damaged tissue that contribute to an inflammatory response." [GOC:jal, ISBN:0721601871]
synonym: "healing during inflammatory response" RELATED [GOC:dph]
synonym: "inflammatory response wound healing" RELATED [GOC:dph]
is_a: GO:0042060 ! wound healing
intersection_of: GO:0042060 ! wound healing
intersection_of: part_of GO:0006954 ! inflammatory response
relationship: part_of GO:0006954 ! inflammatory response
relationship: part_of GO:0090594 ! inflammatory response to wounding

[Term]
id: GO:0002247
name: clearance of damaged tissue involved in inflammatory response wound healing
namespace: biological_process
def: "The series of events leading to removal of necrotic debris that contribute to an inflammatory response." [GOC:jal, ISBN:0721601871]
synonym: "clearance of damaged tissue during inflammatory response" RELATED [GOC:dph]
is_a: GO:0048771 ! tissue remodeling
relationship: part_of GO:0002246 ! wound healing involved in inflammatory response

[Term]
id: GO:0002248
name: connective tissue replacement involved in inflammatory response wound healing
namespace: biological_process
def: "The series of events leading to growth of connective tissue when loss of tissues that are incapable of regeneration occurs, or when fibrinous exudate cannot be adequately cleared that contribute to an inflammatory response." [GOC:jal, ISBN:0721601871]
synonym: "connective tissue replacement during inflammatory response" RELATED [GOC:dph]
synonym: "fibrosis during inflammatory response" NARROW [ISBN:0721601871]
is_a: GO:0048771 ! tissue remodeling
relationship: part_of GO:0002246 ! wound healing involved in inflammatory response

[Term]
id: GO:0002249
name: lymphocyte anergy
namespace: biological_process
def: "Any process contributing to lymphocyte anergy, a state of functional inactivation." [GOC:add]
is_a: GO:0002507 ! tolerance induction

[Term]
id: GO:0002250
name: adaptive immune response
namespace: biological_process
def: "An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory)." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
synonym: "acquired immune response" EXACT [ISBN:068340007X]
xref: Wikipedia:Adaptive_immune_system
is_a: GO:0006955 ! immune response

[Term]
id: GO:0002251
name: organ or tissue specific immune response
namespace: biological_process
def: "An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05]
comment: This term was added by GO_REF:0000022.
synonym: "immune response in organ or tissue" EXACT []
is_a: GO:0006955 ! immune response

[Term]
id: GO:0002252
name: immune effector process
namespace: biological_process
def: "Any process of the immune system that can potentially contribute to an immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002376 ! immune system process

[Term]
id: GO:0002253
name: activation of immune response
namespace: biological_process
def: "Any process that initiates an immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002376 ! immune system process
is_a: GO:0050778 ! positive regulation of immune response

[Term]
id: GO:0002254
name: kinin cascade
namespace: biological_process
def: "A series of reactions that takes place outside the cell that occur as a result of by-products of tissue damage, including collagen, cartilage, and basement membrane. The ultimate product of the kinin cascade include kallidin and bradykinin, agents known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability." [GOC:jal, ISBN:0721601871, PMID:11842287, PMID:14501145]
is_a: GO:0002526 ! acute inflammatory response
is_a: GO:0072376 ! protein activation cascade

[Term]
id: GO:0002255
name: tissue kallikrein-kinin cascade
namespace: biological_process
def: "A series of reactions that takes place outside the cell initiated by the action of tissue (glandular) kallikreins on low molecular weight kininogen in response to tissue damage. Tissue kallikreins are present in glandular tissues and their fluids, such as the salivary glands, sweat glands, pancreas, and kidney. The ultimate products of the tissue kallikrein-kinin cascade include kallidin and bradykinin, agents known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability." [GOC:add, PMID:11842287, PMID:14501145]
synonym: "glandular kallikrein-kinin cascade" EXACT []
is_a: GO:0002254 ! kinin cascade

[Term]
id: GO:0002256
name: regulation of kinin cascade
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the kinin cascade." [GOC:jal]
is_a: GO:0002673 ! regulation of acute inflammatory response
is_a: GO:2000257 ! regulation of protein activation cascade
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002254 ! kinin cascade
relationship: regulates GO:0002254 ! kinin cascade

[Term]
id: GO:0002257
name: negative regulation of kinin cascade
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the kinin cascade." [GOC:jal]
synonym: "down regulation of kinin cascade" EXACT []
synonym: "down-regulation of kinin cascade" EXACT []
synonym: "downregulation of kinin cascade" EXACT []
synonym: "inhibition of kinin cascade" NARROW []
is_a: GO:0002256 ! regulation of kinin cascade
is_a: GO:0002674 ! negative regulation of acute inflammatory response
is_a: GO:2000258 ! negative regulation of protein activation cascade
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002254 ! kinin cascade
relationship: negatively_regulates GO:0002254 ! kinin cascade

[Term]
id: GO:0002258
name: positive regulation of kinin cascade
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of the kinin cascade." [GOC:jal]
synonym: "activation of kinin cascade" NARROW []
synonym: "stimulation of kinin cascade" NARROW []
synonym: "up regulation of kinin cascade" EXACT []
synonym: "up-regulation of kinin cascade" EXACT []
synonym: "upregulation of kinin cascade" EXACT []
is_a: GO:0002256 ! regulation of kinin cascade
is_a: GO:0002675 ! positive regulation of acute inflammatory response
is_a: GO:2000259 ! positive regulation of protein activation cascade
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002254 ! kinin cascade
relationship: positively_regulates GO:0002254 ! kinin cascade

[Term]
id: GO:0002259
name: endothelial cell activation within high endothelial venule involved in immune response
namespace: biological_process
def: "A change in the morphology or behavior of an endothelial cell within a high endothelial venule resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "endothelial cell activation within high endothelial venule during immune response" RELATED [GOC:tb]
is_a: GO:0002264 ! endothelial cell activation involved in immune response

[Term]
id: GO:0002260
name: lymphocyte homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, PMID:15826826, PMID:16319493, PMID:16551252, PMID:16551262]
is_a: GO:0001776 ! leukocyte homeostasis

[Term]
id: GO:0002261
name: mucosal lymphocyte homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within the mucosal tissue of an organism is stable over time in the absence of an outside stimulus." [GOC:add, PMID:15609020]
is_a: GO:0002260 ! lymphocyte homeostasis

[Term]
id: GO:0002262
name: myeloid cell homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [CL:0000763, GOC:add]
is_a: GO:0002376 ! immune system process
is_a: GO:0048872 ! homeostasis of number of cells

[Term]
id: GO:0002263
name: cell activation involved in immune response
namespace: biological_process
def: "A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
synonym: "cell activation during immune response" RELATED [GOC:tb]
is_a: GO:0001775 ! cell activation
is_a: GO:0002252 ! immune effector process
intersection_of: GO:0001775 ! cell activation
intersection_of: part_of GO:0006955 ! immune response
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0002264
name: endothelial cell activation involved in immune response
namespace: biological_process
def: "A change in the morphology or behavior of an endothelial cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "endothelial cell activation during immune response" RELATED [GOC:tb]
is_a: GO:0002263 ! cell activation involved in immune response
is_a: GO:0042118 ! endothelial cell activation
intersection_of: GO:0042118 ! endothelial cell activation
intersection_of: part_of GO:0006955 ! immune response
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0002265
name: astrocyte activation involved in immune response
namespace: biological_process
def: "A change in the morphology or behavior of an astrocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:11138785]
synonym: "astrocyte activation during immune response" RELATED [GOC:tb]
is_a: GO:0002263 ! cell activation involved in immune response
is_a: GO:0048143 ! astrocyte activation
intersection_of: GO:0048143 ! astrocyte activation
intersection_of: part_of GO:0006955 ! immune response
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0002266
name: follicular dendritic cell activation
namespace: biological_process
def: "A change in the morphology or behavior of a follicular dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:add, PMID:15606789]
is_a: GO:0001775 ! cell activation

[Term]
id: GO:0002267
name: follicular dendritic cell activation involved in immune response
namespace: biological_process
def: "A change in the morphology or behavior of a follicular dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15606789]
synonym: "follicular dendritic cell activation during immune response" RELATED [GOC:tb]
is_a: GO:0002263 ! cell activation involved in immune response
is_a: GO:0002266 ! follicular dendritic cell activation
intersection_of: GO:0002266 ! follicular dendritic cell activation
intersection_of: part_of GO:0006955 ! immune response
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0002268
name: follicular dendritic cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized precursor cell acquires the specialized features of a follicular dendritic cell." [GOC:add, ISBN:0781735149]
is_a: GO:0002266 ! follicular dendritic cell activation
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0002269
name: leukocyte activation involved in inflammatory response
namespace: biological_process
def: "A change in the morphology or behavior of a leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an inflammatory response." [GOC:add, ISBN:0781735149]
synonym: "immune cell activation during inflammatory response" RELATED []
synonym: "leukocyte activation during inflammatory response" RELATED [GOC:tb]
is_a: GO:0045321 ! leukocyte activation
intersection_of: GO:0045321 ! leukocyte activation
intersection_of: part_of GO:0006954 ! inflammatory response
relationship: part_of GO:0006954 ! inflammatory response

[Term]
id: GO:0002270
name: plasmacytoid dendritic cell activation
namespace: biological_process
def: "A change in the morphology or behavior of a plasmacytoid dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:add, PMID:15990333, PMID:16174109]
is_a: GO:0045321 ! leukocyte activation

[Term]
id: GO:0002271
name: plasmacytoid dendritic cell activation involved in immune response
namespace: biological_process
def: "A change in the morphology or behavior of a plasmacytoid dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15990333, PMID:16174109]
synonym: "plasmacytoid dendritic cell activation during immune response" RELATED [GOC:tb]
is_a: GO:0002270 ! plasmacytoid dendritic cell activation
is_a: GO:0002366 ! leukocyte activation involved in immune response
intersection_of: GO:0002270 ! plasmacytoid dendritic cell activation
intersection_of: part_of GO:0006955 ! immune response
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0002272
name: plasmacytoid dendritic cell differentiation involved in immune response
namespace: biological_process
def: "The process in which an immature plasmacytoid dendritic cell acquires the specialized features of a mature plasmacytoid dendritic cell contributing to an immune response." [GOC:add, PMID:15990333]
synonym: "plasmacytoid dendritic cell differentiation during immune response" RELATED [GOC:dph]
is_a: GO:0002271 ! plasmacytoid dendritic cell activation involved in immune response
is_a: GO:0002273 ! plasmacytoid dendritic cell differentiation
intersection_of: GO:0002273 ! plasmacytoid dendritic cell differentiation
intersection_of: part_of GO:0006955 ! immune response
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0002273
name: plasmacytoid dendritic cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a plasmacytoid dendritic cell." [GOC:add, PMID:15990333, PMID:16174108]
is_a: GO:0002270 ! plasmacytoid dendritic cell activation
is_a: GO:0097028 ! dendritic cell differentiation

[Term]
id: GO:0002274
name: myeloid leukocyte activation
namespace: biological_process
def: "A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:add, ISBN:0781735149]
synonym: "myeloid leucocyte activation" EXACT []
is_a: GO:0045321 ! leukocyte activation

[Term]
id: GO:0002275
name: myeloid cell activation involved in immune response
namespace: biological_process
def: "A change in the morphology or behavior of a myeloid cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "myeloid cell activation during immune response" RELATED [GOC:tb]
is_a: GO:0002274 ! myeloid leukocyte activation
is_a: GO:0002366 ! leukocyte activation involved in immune response

[Term]
id: GO:0002276
name: basophil activation involved in immune response
namespace: biological_process
def: "A change in morphology and behavior of a basophil resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the basophil has specifically bound via IgE bound to Fc-epsilonRI receptors, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "basophil activation during immune response" RELATED [GOC:tb]
is_a: GO:0002275 ! myeloid cell activation involved in immune response
is_a: GO:0045575 ! basophil activation
intersection_of: GO:0045575 ! basophil activation
intersection_of: part_of GO:0006955 ! immune response
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0002277
name: myeloid dendritic cell activation involved in immune response
namespace: biological_process
def: "The change in morphology and behavior of a myeloid dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "myeloid dendritic cell activation during immune response" RELATED [GOC:tb]
is_a: GO:0001773 ! myeloid dendritic cell activation
is_a: GO:0002275 ! myeloid cell activation involved in immune response
intersection_of: GO:0001773 ! myeloid dendritic cell activation
intersection_of: part_of GO:0006955 ! immune response
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0002278
name: eosinophil activation involved in immune response
namespace: biological_process
def: "The change in morphology and behavior of a eosinophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "eosinophil activation during immune response" RELATED [GOC:tb]
is_a: GO:0002275 ! myeloid cell activation involved in immune response
is_a: GO:0043307 ! eosinophil activation
intersection_of: GO:0043307 ! eosinophil activation
intersection_of: part_of GO:0006955 ! immune response
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0002279
name: mast cell activation involved in immune response
namespace: biological_process
def: "The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "mast cell activation during immune response" RELATED [GOC:tb]
is_a: GO:0002275 ! myeloid cell activation involved in immune response
is_a: GO:0045576 ! mast cell activation
intersection_of: GO:0045576 ! mast cell activation
intersection_of: part_of GO:0006955 ! immune response
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0002280
name: monocyte activation involved in immune response
namespace: biological_process
def: "The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149, PMID:16551245]
synonym: "monocyte activation during immune response" RELATED [GOC:tb]
is_a: GO:0002275 ! myeloid cell activation involved in immune response
is_a: GO:0042117 ! monocyte activation
intersection_of: GO:0042117 ! monocyte activation
intersection_of: part_of GO:0006955 ! immune response
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0002281
name: macrophage activation involved in immune response
namespace: biological_process
def: "A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "macrophage activation during immune response" RELATED [GOC:tb]
is_a: GO:0002275 ! myeloid cell activation involved in immune response
is_a: GO:0042116 ! macrophage activation
intersection_of: GO:0042116 ! macrophage activation
intersection_of: part_of GO:0006955 ! immune response
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0002282
name: microglial cell activation involved in immune response
namespace: biological_process
def: "The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "microglial cell activation during immune response" RELATED [GOC:tb]
is_a: GO:0001774 ! microglial cell activation
is_a: GO:0002281 ! macrophage activation involved in immune response
intersection_of: GO:0001774 ! microglial cell activation
intersection_of: part_of GO:0006955 ! immune response
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0002283
name: neutrophil activation involved in immune response
namespace: biological_process
def: "The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "neutrophil activation during immune response" RELATED [GOC:tb]
is_a: GO:0002275 ! myeloid cell activation involved in immune response
is_a: GO:0042119 ! neutrophil activation
intersection_of: GO:0042119 ! neutrophil activation
intersection_of: part_of GO:0006955 ! immune response
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0002284
name: myeloid dendritic cell differentiation involved in immune response
namespace: biological_process
def: "The process in which an immature myeloid dendritic cell acquires the specialized features of a mature myeloid dendritic cell as part of an immune response." [GOC:add, ISBN:0781735149]
synonym: "myeloid dendritic cell differentiation during immune response" RELATED [GOC:tb]
is_a: GO:0002277 ! myeloid dendritic cell activation involved in immune response
is_a: GO:0043011 ! myeloid dendritic cell differentiation
intersection_of: GO:0043011 ! myeloid dendritic cell differentiation
intersection_of: part_of GO:0006955 ! immune response
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0002285
name: lymphocyte activation involved in immune response
namespace: biological_process
def: "A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "lymphocyte activation during immune response" RELATED [GOC:tb]
is_a: GO:0002366 ! leukocyte activation involved in immune response
is_a: GO:0046649 ! lymphocyte activation
intersection_of: GO:0046649 ! lymphocyte activation
intersection_of: part_of GO:0006955 ! immune response
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0002286
name: T cell activation involved in immune response
namespace: biological_process
def: "The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "T cell activation during immune response" RELATED [GOC:tb]
synonym: "T lymphocyte activation during immune response" RELATED []
synonym: "T-cell activation during immune response" RELATED []
synonym: "T-lymphocyte activation during immune response" RELATED []
is_a: GO:0002285 ! lymphocyte activation involved in immune response
is_a: GO:0042110 ! T cell activation
intersection_of: GO:0042110 ! T cell activation
intersection_of: part_of GO:0006955 ! immune response
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0002287
name: alpha-beta T cell activation involved in immune response
namespace: biological_process
def: "The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "alpha-beta T cell activation during immune response" RELATED [GOC:tb]
synonym: "alpha-beta T lymphocyte activation during immune response" RELATED []
synonym: "alpha-beta T-cell activation during immune response" RELATED []
synonym: "alpha-beta T-lymphocyte activation during immune response" RELATED []
is_a: GO:0002286 ! T cell activation involved in immune response
is_a: GO:0046631 ! alpha-beta T cell activation
intersection_of: GO:0046631 ! alpha-beta T cell activation
intersection_of: part_of GO:0006955 ! immune response
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0002288
name: NK T cell activation involved in immune response
namespace: biological_process
def: "The change in morphology and behavior of a mature or immature natural killer T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15771592]
synonym: "natural killer T lymphocyte activation during immune response" RELATED []
synonym: "natural killer T-cell activation during immune response" RELATED []
synonym: "natural killer T-lymphocyte activation during immune response" RELATED []
synonym: "NK T cell activation during immune response" RELATED [GOC:tb]
synonym: "NK T lymphocyte activation during immune response" RELATED []
synonym: "NK T-cell activation during immune response" RELATED []
synonym: "NK T-lymphocyte activation during immune response" RELATED []
is_a: GO:0002287 ! alpha-beta T cell activation involved in immune response
is_a: GO:0051132 ! NK T cell activation
intersection_of: GO:0051132 ! NK T cell activation
intersection_of: part_of GO:0006955 ! immune response
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0002289
name: NK T cell proliferation involved in immune response
namespace: biological_process
def: "The expansion of a NK T cell population by cell division as part of an immune response." [GOC:add, PMID:15771592]
synonym: "natural killer T lymphocyte proliferation during immune response" RELATED []
synonym: "natural killer T-cell proliferation during immune response" RELATED []
synonym: "natural killer T-lymphocyte proliferation during immune response" RELATED []
synonym: "NK T cell proliferation during immune response" RELATED [GOC:tb]
synonym: "NK T lymphocyte proliferation during immune response" RELATED []
synonym: "NK T-cell proliferation during immune response" RELATED []
synonym: "NK T-lymphocyte proliferation during immune response" RELATED []
is_a: GO:0001866 ! NK T cell proliferation
is_a: GO:0002288 ! NK T cell activation involved in immune response
is_a: GO:0002310 ! alpha-beta T cell proliferation involved in immune response
intersection_of: GO:0001866 ! NK T cell proliferation
intersection_of: part_of GO:0006955 ! immune response
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0002290
name: gamma-delta T cell activation involved in immune response
namespace: biological_process
def: "The change in morphology and behavior of a gamma-delta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:8717523]
synonym: "gamma-delta T cell activation during immune response" RELATED [GOC:tb]
synonym: "gamma-delta T lymphocyte activation during immune response" RELATED []
synonym: "gamma-delta T-cell activation during immune response" RELATED []
synonym: "gamma-delta T-lymphocyte activation during immune response" RELATED []
is_a: GO:0002286 ! T cell activation involved in immune response
is_a: GO:0046629 ! gamma-delta T cell activation
intersection_of: GO:0046629 ! gamma-delta T cell activation
intersection_of: part_of GO:0006955 ! immune response
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0002291
name: T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
namespace: biological_process
def: "The change in morphology and behavior of a mature or immature T cell resulting from exposure to an antigen for which its T cell receptor is specific bound to an MHC molecule on an antigen presenting cell, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "T lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT []
synonym: "T-cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT []
synonym: "T-lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT []
is_a: GO:0002286 ! T cell activation involved in immune response

[Term]
id: GO:0002292
name: T cell differentiation involved in immune response
namespace: biological_process
def: "The process in which an antigenically naive T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "T cell development involved in immune response" RELATED [GOC:add]
synonym: "T cell differentiation during immune response" RELATED [GOC:tb]
synonym: "T lymphocyte differentiation during immune response" RELATED []
synonym: "T-cell differentiation during immune response" RELATED []
synonym: "T-lymphocyte differentiation during immune response" RELATED []
is_a: GO:0002286 ! T cell activation involved in immune response
is_a: GO:0030217 ! T cell differentiation
intersection_of: GO:0030217 ! T cell differentiation
intersection_of: part_of GO:0006955 ! immune response
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0002293
name: alpha-beta T cell differentiation involved in immune response
namespace: biological_process
def: "The process in which an antigenically naive alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "alpha-beta T cell development involved in immune response" RELATED [GOC:add]
synonym: "alpha-beta T cell differentiation during immune response" RELATED [GOC:tb]
synonym: "alpha-beta T lymphocyte differentiation during immune response" RELATED []
synonym: "alpha-beta T-cell differentiation during immune response" RELATED []
synonym: "alpha-beta T-lymphocyte differentiation during immune response" RELATED []
is_a: GO:0002287 ! alpha-beta T cell activation involved in immune response
is_a: GO:0002292 ! T cell differentiation involved in immune response
is_a: GO:0046632 ! alpha-beta T cell differentiation
intersection_of: GO:0046632 ! alpha-beta T cell differentiation
intersection_of: part_of GO:0006955 ! immune response
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0002294
name: CD4-positive, alpha-beta T cell differentiation involved in immune response
namespace: biological_process
def: "The process in which an antigenically naive CD4-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "CD4-positive, alpha-beta T cell development involved in immune response" RELATED [GOC:add]
synonym: "CD4-positive, alpha-beta T cell differentiation during immune response" RELATED [GOC:tb]
synonym: "CD4-positive, alpha-beta T lymphocyte differentiation during immune response" RELATED []
synonym: "CD4-positive, alpha-beta T-cell differentiation during immune response" RELATED []
synonym: "CD4-positive, alpha-beta T-lymphocyte differentiation during immune response" RELATED []
is_a: GO:0002293 ! alpha-beta T cell differentiation involved in immune response
is_a: GO:0043367 ! CD4-positive, alpha-beta T cell differentiation
intersection_of: GO:0043367 ! CD4-positive, alpha-beta T cell differentiation
intersection_of: part_of GO:0006955 ! immune response
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0002295
name: T-helper cell lineage commitment
namespace: biological_process
def: "The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper cell, a CD4-positive, alpha-beta T cell specialized to promote various immunological processes." [GOC:add, ISBN:0781735149]
synonym: "T-helper cell fate commitment" EXACT []
synonym: "Th0 lineage commitment" RELATED [ISBN:0781735149]
synonym: "Thp lineage commitment" RELATED [ISBN:0781735149]
is_a: GO:0043373 ! CD4-positive, alpha-beta T cell lineage commitment
relationship: part_of GO:0042093 ! T-helper cell differentiation

[Term]
id: GO:0002296
name: T-helper 1 cell lineage commitment
namespace: biological_process
def: "The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 1 cell, a CD4-positive, alpha-beta T cell specialized to promote immunological processes often associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis." [GOC:add, ISBN:0781735149]
synonym: "T-helper 1 cell fate commitment" EXACT [ISBN:0781735149]
synonym: "Th1 cell lineage commitment" EXACT [ISBN:0781735149]
synonym: "Th1 fate commitment" EXACT [ISBN:0781735149]
is_a: GO:0002295 ! T-helper cell lineage commitment
relationship: part_of GO:0045063 ! T-helper 1 cell differentiation

[Term]
id: GO:0002297
name: T-helper 2 cell lineage commitment
namespace: biological_process
def: "The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 2 cell, a CD4-positive, alpha-beta T cell specialized to promote immunological processes often associated with resistance to extracellular organisms such as helminths, enhanced production of particular antibody isotypes, and pathological conditions such as allergy." [GOC:add, ISBN:0781735149]
synonym: "T-helper 2 cell fate commitment" EXACT [ISBN:0781735149]
synonym: "Th2 fate commitment" EXACT [ISBN:0781735149]
is_a: GO:0002295 ! T-helper cell lineage commitment
relationship: part_of GO:0045064 ! T-helper 2 cell differentiation

[Term]
id: GO:0002298
name: CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response
namespace: biological_process
def: "The process in which an antigenically naive CD4-positive, alpha-beta T cell acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell as part of an immune response." [GOC:add, PMID:12093005]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [GOC:tb]
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response" RELATED []
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response" RELATED []
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response" RELATED []
synonym: "CD4-positive, CD25-positive, alpha-beta T cell development involved in immune response" RELATED [GOC:add]
is_a: GO:0002294 ! CD4-positive, alpha-beta T cell differentiation involved in immune response
is_a: GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
intersection_of: GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
intersection_of: part_of GO:0006955 ! immune response
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0002299
name: alpha-beta intraepithelial T cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of an alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "alpha-beta intraepithelial T cell development" RELATED [GOC:add]
synonym: "alpha-beta intraepithelial T lymphocyte differentiation" EXACT []
synonym: "alpha-beta intraepithelial T-cell differentiation" EXACT []
synonym: "alpha-beta intraepithelial T-lymphocyte differentiation" EXACT []
is_a: GO:0046632 ! alpha-beta T cell differentiation

[Term]
id: GO:0002300
name: CD8-positive, alpha-beta intraepithelial T cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "CD8-positive, alpha-beta intraepithelial T cell development" RELATED [GOC:add]
synonym: "CD8-positive, alpha-beta intraepithelial T lymphocyte differentiation" EXACT []
synonym: "CD8-positive, alpha-beta intraepithelial T-cell differentiation" EXACT []
synonym: "CD8-positive, alpha-beta intraepithelial T-lymphocyte differentiation" EXACT []
is_a: GO:0002299 ! alpha-beta intraepithelial T cell differentiation
is_a: GO:0043374 ! CD8-positive, alpha-beta T cell differentiation

[Term]
id: GO:0002301
name: CD4-positive, alpha-beta intraepithelial T cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a CD4-positive, alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "CD4-positive, alpha-beta intraepithelial T cell development" RELATED [GOC:add]
synonym: "CD4-positive, alpha-beta intraepithelial T lymphocyte differentiation" EXACT []
synonym: "CD4-positive, alpha-beta intraepithelial T-cell differentiation" EXACT []
synonym: "CD4-positive, alpha-beta intraepithelial T-lymphocyte differentiation" EXACT []
is_a: GO:0002299 ! alpha-beta intraepithelial T cell differentiation
is_a: GO:0043367 ! CD4-positive, alpha-beta T cell differentiation

[Term]
id: GO:0002302
name: CD8-positive, alpha-beta T cell differentiation involved in immune response
namespace: biological_process
def: "The process in which an antigenically naive CD8-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "CD8-positive, alpha-beta intraepithelial T cell development" RELATED [GOC:add]
synonym: "CD8-positive, alpha-beta T cell differentiation during immune response" RELATED [GOC:tb]
synonym: "CD8-positive, alpha-beta T lymphocyte differentiation during immune response" RELATED []
synonym: "CD8-positive, alpha-beta T-cell differentiation during immune response" RELATED []
synonym: "CD8-positive, alpha-beta T-lymphocyte differentiation during immune response" RELATED []
is_a: GO:0002293 ! alpha-beta T cell differentiation involved in immune response
is_a: GO:0043374 ! CD8-positive, alpha-beta T cell differentiation
intersection_of: GO:0043374 ! CD8-positive, alpha-beta T cell differentiation
intersection_of: part_of GO:0006955 ! immune response
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0002303
name: gamma-delta T cell differentiation involved in immune response
namespace: biological_process
def: "The process in which an antigenically naive gamma-delta T cell acquires the specialized features of an effector, regulatory, or memory T cell and contributes to an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "gamma-delta T cell development involved in immune response" RELATED [GOC:add]
synonym: "gamma-delta T cell differentiation during immune response" RELATED [GOC:dph]
synonym: "gamma-delta T lymphocyte differentiation during immune response" RELATED []
synonym: "gamma-delta T-cell differentiation during immune response" RELATED []
synonym: "gamma-delta T-lymphocyte differentiation during immune response" RELATED []
is_a: GO:0002290 ! gamma-delta T cell activation involved in immune response
is_a: GO:0002292 ! T cell differentiation involved in immune response
is_a: GO:0042492 ! gamma-delta T cell differentiation
intersection_of: GO:0042492 ! gamma-delta T cell differentiation
intersection_of: part_of GO:0006955 ! immune response
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0002304
name: gamma-delta intraepithelial T cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "gamma-delta intraepithelial T cell development" RELATED [GOC:add]
synonym: "gamma-delta intraepithelial T lymphocyte differentiation" EXACT []
synonym: "gamma-delta intraepithelial T-cell differentiation" EXACT []
synonym: "gamma-delta intraepithelial T-lymphocyte differentiation" EXACT []
is_a: GO:0042492 ! gamma-delta T cell differentiation

[Term]
id: GO:0002305
name: CD8-positive, gamma-delta intraepithelial T cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a CD8-positive, gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "CD8-positive, gamma-delta intraepithelial T cell development" RELATED [GOC:add]
synonym: "CD8-positive, gamma-delta intraepithelial T lymphocyte differentiation" EXACT []
synonym: "CD8-positive, gamma-delta intraepithelial T-cell differentiation" EXACT []
synonym: "CD8-positive, gamma-delta intraepithelial T-lymphocyte differentiation" EXACT []
is_a: GO:0002304 ! gamma-delta intraepithelial T cell differentiation

[Term]
id: GO:0002306
name: CD4-positive gamma-delta intraepithelial T cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a CD4-positive, gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "CD4-positive, gamma-delta intraepithelial T cell development" RELATED [GOC:add]
synonym: "CD4-positive, gamma-delta intraepithelial T lymphocyte differentiation" EXACT []
synonym: "CD4-positive, gamma-delta intraepithelial T-cell differentiation" EXACT []
synonym: "CD4-positive, gamma-delta intraepithelial T-lymphocyte differentiation" EXACT []
is_a: GO:0002304 ! gamma-delta intraepithelial T cell differentiation

[Term]
id: GO:0002307
name: CD8-positive, alpha-beta regulatory T cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta regulatory T cell." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "CD8-positive, alpha-beta regulatory T cell development" RELATED [GOC:add]
synonym: "CD8-positive, alpha-beta regulatory T lymphocyte differentiation" EXACT []
synonym: "CD8-positive, alpha-beta regulatory T-cell differentiation" EXACT []
synonym: "CD8-positive, alpha-beta regulatory T-lymphocyte differentiation" EXACT []
is_a: GO:0043374 ! CD8-positive, alpha-beta T cell differentiation
is_a: GO:0045066 ! regulatory T cell differentiation

[Term]
id: GO:0002308
name: CD8-positive, alpha-beta cytotoxic T cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta cytotoxic T cell." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "CD8-positive, alpha-beta cytotoxic T cell development" RELATED [GOC:add]
synonym: "CD8-positive, alpha-beta cytotoxic T lymphocyte differentiation" EXACT []
synonym: "CD8-positive, alpha-beta cytotoxic T-cell differentiation" EXACT []
synonym: "CD8-positive, alpha-beta cytotoxic T-lymphocyte differentiation" EXACT []
is_a: GO:0043374 ! CD8-positive, alpha-beta T cell differentiation
is_a: GO:0045065 ! cytotoxic T cell differentiation

[Term]
id: GO:0002309
name: T cell proliferation involved in immune response
namespace: biological_process
def: "The expansion of a T cell population by cell division as part of an immune response." [GOC:add, ISBN:0781735149]
synonym: "T cell proliferation during immune response" RELATED [GOC:tb]
synonym: "T lymphocyte proliferation during immune response" RELATED []
synonym: "T-cell proliferation during immune response" RELATED []
synonym: "T-lymphocyte proliferation during immune response" RELATED []
is_a: GO:0002286 ! T cell activation involved in immune response
is_a: GO:0042098 ! T cell proliferation
intersection_of: GO:0042098 ! T cell proliferation
intersection_of: part_of GO:0006955 ! immune response
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0002310
name: alpha-beta T cell proliferation involved in immune response
namespace: biological_process
def: "The expansion of an alpha-beta T cell population by cell division as part of an immune response." [GOC:add, ISBN:0781735149]
synonym: "alpha-beta T cell proliferation during immune response" RELATED [GOC:tb]
synonym: "alpha-beta T lymphocyte proliferation during immune response" RELATED []
synonym: "alpha-beta T-cell proliferation during immune response" RELATED []
synonym: "alpha-beta T-lymphocyte proliferation during immune response" RELATED []
is_a: GO:0002287 ! alpha-beta T cell activation involved in immune response
is_a: GO:0002309 ! T cell proliferation involved in immune response
is_a: GO:0046633 ! alpha-beta T cell proliferation
intersection_of: GO:0046633 ! alpha-beta T cell proliferation
intersection_of: part_of GO:0006955 ! immune response
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0002311
name: gamma-delta T cell proliferation involved in immune response
namespace: biological_process
def: "The expansion of a gamma-delta T cell population by cell division as part of an immune response." [GOC:add]
synonym: "gamma-delta T cell proliferation during immune response" RELATED [GOC:tb]
synonym: "gamma-delta T lymphocyte proliferation during immune response" RELATED []
synonym: "gamma-delta T-cell proliferation during immune response" RELATED []
synonym: "gamma-delta T-lymphocyte proliferation during immune response" RELATED []
is_a: GO:0002290 ! gamma-delta T cell activation involved in immune response
is_a: GO:0002309 ! T cell proliferation involved in immune response
is_a: GO:0046630 ! gamma-delta T cell proliferation
intersection_of: GO:0046630 ! gamma-delta T cell proliferation
intersection_of: part_of GO:0006955 ! immune response
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0002312
name: B cell activation involved in immune response
namespace: biological_process
def: "The change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:jal]
synonym: "B cell activation during immune response" RELATED [GOC:tb]
synonym: "B lymphocyte activation during immune response" RELATED []
synonym: "B-cell activation during immune response" RELATED []
synonym: "B-lymphocyte activation during immune response" RELATED []
is_a: GO:0002285 ! lymphocyte activation involved in immune response
is_a: GO:0042113 ! B cell activation
intersection_of: GO:0042113 ! B cell activation
intersection_of: part_of GO:0006955 ! immune response
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0002313
name: mature B cell differentiation involved in immune response
namespace: biological_process
def: "The process in which a naive B cell acquires the specialized features of a mature or memory B cell during an immune response." [GOC:jal]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "mature B cell development involved in immune response" RELATED [GOC:add]
synonym: "mature B cell differentiation during immune response" RELATED [GOC:tb]
synonym: "mature B lymphocyte differentiation during immune response" RELATED []
synonym: "mature B-cell differentiation during immune response" RELATED []
synonym: "mature B-lymphocyte differentiation during immune response" RELATED []
is_a: GO:0002312 ! B cell activation involved in immune response
is_a: GO:0002335 ! mature B cell differentiation
intersection_of: GO:0002335 ! mature B cell differentiation
intersection_of: part_of GO:0006955 ! immune response
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0002314
name: germinal center B cell differentiation
namespace: biological_process
def: "The process in which a B cell in the spleen acquires the specialized features of a germinal center B cell. Germinal center B cells are rapidly cycling B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA)." [GOC:jal, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "germinal center B cell development" RELATED [GOC:add]
synonym: "germinal center B lymphocyte differentiation" EXACT []
synonym: "germinal center B-cell differentiation" EXACT []
synonym: "germinal center B-lymphocyte differentiation" EXACT []
is_a: GO:0002313 ! mature B cell differentiation involved in immune response

[Term]
id: GO:0002315
name: marginal zone B cell differentiation
namespace: biological_process
def: "The process in which a B cell in the spleen acquires the specialized features of a marginal zone B cell. Marginal zone B cells are localized in a distinct anatomical region of the spleen that represents the major antigen-filtering and scavenging area (by specialized macrophages resident there). It appears that they are preselected to express a BCR repertoire similar to B-1 B cells, biased toward bacterial cell wall constituents and senescent self-components (such as oxidized LDL)." [GOC:jal, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "marginal zone B cell development" RELATED [GOC:add]
synonym: "marginal zone B lymphocyte differentiation" EXACT []
synonym: "marginal zone B-cell differentiation" EXACT []
synonym: "marginal zone B-lymphocyte differentiation" EXACT []
is_a: GO:0002313 ! mature B cell differentiation involved in immune response

[Term]
id: GO:0002316
name: follicular B cell differentiation
namespace: biological_process
def: "The process in which a B cell in the spleen acquires the specialized features of a follicular B cell. Follicular B cells are major population of mature recirculating B cells in the spleen and are located in the B-cell follicle region." [GOC:jal, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "follicular B cell development" RELATED [GOC:add]
synonym: "follicular B lymphocyte differentiation" EXACT []
synonym: "follicular B-cell differentiation" EXACT []
synonym: "follicular B-lymphocyte differentiation" EXACT []
is_a: GO:0002313 ! mature B cell differentiation involved in immune response

[Term]
id: GO:0002317
name: plasma cell differentiation
namespace: biological_process
def: "The process in which a B cell acquires the specialized features of a plasma cell. A plasma cell is a lymphocyte which develops from a B cell and produces high amounts of antibody." [GOC:jal]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "plasma cell development" RELATED [GOC:add]
is_a: GO:0002313 ! mature B cell differentiation involved in immune response

[Term]
id: GO:0002318
name: myeloid progenitor cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a myeloid progenitor cell. Myeloid progenitor cells include progenitor cells for any of the myeloid lineages." [GOC:add, PMID:16551264]
is_a: GO:0002244 ! hematopoietic progenitor cell differentiation

[Term]
id: GO:0002319
name: memory B cell differentiation
namespace: biological_process
def: "The process in which a B cell acquires the specialized features of a memory B cell. Memory B cells are cells that can respond rapidly to antigen re-exposure by production of high-affinity antibody." [GOC:jal, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "memory B cell development" RELATED [GOC:add]
synonym: "memory B lymphocyte differentiation" EXACT []
synonym: "memory B-cell differentiation" EXACT []
synonym: "memory B-lymphocyte differentiation" EXACT []
is_a: GO:0002313 ! mature B cell differentiation involved in immune response

[Term]
id: GO:0002320
name: lymphoid progenitor cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a lymphoid progenitor cell. Lymphoid progenitor cells include progenitor cells for any of the lymphoid lineages." [GOC:add, PMID:16551251, PMID:16551264]
is_a: GO:0002244 ! hematopoietic progenitor cell differentiation

[Term]
id: GO:0002321
name: natural killer cell progenitor differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a natural killer cell progenitor." [GOC:add, PMID:16551251, PMID:16551264]
is_a: GO:0002320 ! lymphoid progenitor cell differentiation

[Term]
id: GO:0002322
name: B cell proliferation involved in immune response
namespace: biological_process
def: "The expansion of a B cell population by cell division following B cell activation during an immune response." [GOC:jal]
synonym: "B cell proliferation during immune response" RELATED [GOC:tb]
synonym: "B lymphocyte proliferation during immune response" RELATED []
synonym: "B-cell proliferation during immune response" RELATED []
synonym: "B-lymphocyte proliferation during immune response" RELATED []
is_a: GO:0002312 ! B cell activation involved in immune response
is_a: GO:0042100 ! B cell proliferation
intersection_of: GO:0042100 ! B cell proliferation
intersection_of: part_of GO:0006955 ! immune response
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0002323
name: natural killer cell activation involved in immune response
namespace: biological_process
def: "The change in morphology and behavior of a natural killer cell resulting from exposure a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15032583]
synonym: "natural killer cell activation during immune response" RELATED [GOC:tb]
synonym: "NK cell activation during immune response" RELATED []
is_a: GO:0002285 ! lymphocyte activation involved in immune response
is_a: GO:0030101 ! natural killer cell activation
intersection_of: GO:0030101 ! natural killer cell activation
intersection_of: part_of GO:0006955 ! immune response
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0002324
name: natural killer cell proliferation involved in immune response
namespace: biological_process
def: "The expansion of a natural killer cell population by cell division as part of an immune response." [GOC:add, PMID:15032583]
synonym: "natural killer cell proliferation during immune response" RELATED [GOC:tb]
synonym: "NK cell proliferation during immune response" RELATED []
is_a: GO:0001787 ! natural killer cell proliferation
is_a: GO:0002323 ! natural killer cell activation involved in immune response
intersection_of: GO:0001787 ! natural killer cell proliferation
intersection_of: part_of GO:0006955 ! immune response
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0002325
name: natural killer cell differentiation involved in immune response
namespace: biological_process
def: "The process in which a naive natural killer cell acquires the specialized features of an effector natural killer T cell as part of an immune response." [GOC:add, PMID:11698225]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "natural killer cell development involved in immune response" RELATED [GOC:add]
synonym: "natural killer cell differentiation during immune response" RELATED [GOC:tb]
synonym: "NK cell differentiation during immune response" RELATED []
is_a: GO:0001779 ! natural killer cell differentiation
is_a: GO:0002323 ! natural killer cell activation involved in immune response
intersection_of: GO:0001779 ! natural killer cell differentiation
intersection_of: part_of GO:0006955 ! immune response
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0002326
name: B cell lineage commitment
namespace: biological_process
def: "The process in which a lymphoid progenitor cell becomes committed to become any type of B cell." [GOC:add, ISBN:0781735149]
synonym: "B lymphocyte lineage commitment" EXACT []
synonym: "B-cell lineage commitment" EXACT []
synonym: "B-lymphocyte lineage commitment" EXACT []
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0030183 ! B cell differentiation

[Term]
id: GO:0002327
name: immature B cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of an immature B cell." [GOC:jal, ISBN:0781735149, PMID:16551251]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "immature B cell development" RELATED [GOC:add]
synonym: "immature B lymphocyte differentiation" EXACT []
synonym: "immature B-cell differentiation" EXACT []
synonym: "immature B-lymphocyte differentiation" EXACT []
is_a: GO:0030183 ! B cell differentiation

[Term]
id: GO:0002328
name: pro-B cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a pro-B cell. Pro-B cells are the earliest stage of the B cell lineage and undergo heavy chain D and J gene rearrangements, although they are not fully committed." [GOC:jal, ISBN:0781735149]
synonym: "pro-B cell development" RELATED [GOC:add]
synonym: "pro-B lymphocyte differentiation" EXACT []
is_a: GO:0002320 ! lymphoid progenitor cell differentiation

[Term]
id: GO:0002329
name: pre-B cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a pre-B cell. Pre-B cells follow the pro-B cell stage of immature B cell differentiation and undergo rearrangement of heavy chain V, D, and J gene segments." [GOC:jal, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "pre-B cell development" RELATED [GOC:add]
synonym: "pre-B lymphocyte differentiation" EXACT []
is_a: GO:0002327 ! immature B cell differentiation

[Term]
id: GO:0002330
name: pre-B cell receptor expression
namespace: biological_process
def: "The process leading up to expression of the pre-B cell receptor on the surface of pre-B cells, including expression of the surrogate light chain, association of the surrogate light chain with heavy chain, and expression of the complete pre-B cell receptor on the cell surface." [GOC:add, GOC:jal, ISBN:0781735149]
is_a: GO:0010467 ! gene expression
relationship: part_of GO:0002329 ! pre-B cell differentiation

[Term]
id: GO:0002331
name: pre-B cell allelic exclusion
namespace: biological_process
def: "Expression of a single heavy chain allele during pre-B cell differentiation." [GOC:add, GOC:jal, ISBN:0781735149]
synonym: "pre-B lymphocyte allelic exclusion" EXACT []
is_a: GO:0010468 ! regulation of gene expression
relationship: part_of GO:0002329 ! pre-B cell differentiation

[Term]
id: GO:0002332
name: transitional stage B cell differentiation
namespace: biological_process
def: "The process in which immature B cells from the bone marrow become mature B cells in the spleen. Transitional stage B cells are subdivided into transitional one (T1) and transitional two (T2) stages and are short-lived and functionally incompetent." [GOC:jal, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "transitional stage B cell development" RELATED [GOC:add]
synonym: "transitional stage B lymphocyte differentiation" EXACT []
synonym: "transitional stage B-cell differentiation" EXACT []
synonym: "transitional stage B-lymphocyte differentiation" EXACT []
is_a: GO:0002327 ! immature B cell differentiation

[Term]
id: GO:0002333
name: transitional one stage B cell differentiation
namespace: biological_process
def: "The process in which immature B cells from the bone marrow acquire the specialized features of T1 stage B cells in the spleen. T1 stage B cells do not express either CD23 or CD21." [GOC:jal, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "T1 stage B cell differentiation" EXACT []
synonym: "transitional one stage B cell development" RELATED [GOC:add]
synonym: "transitional one stage B lymphocyte differentiation" EXACT []
synonym: "transitional one stage B-cell differentiation" EXACT []
synonym: "transitional one stage B-lymphocyte differentiation" EXACT []
is_a: GO:0002332 ! transitional stage B cell differentiation

[Term]
id: GO:0002334
name: transitional two stage B cell differentiation
namespace: biological_process
def: "The process in which immature B cells from the bone marrow acquire the specialized features of T2 stage B cells in the spleen. T2 stage B cells express CD23 but not CD21." [GOC:jal, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "T2 stage B cell differentiation" EXACT []
synonym: "transitional two stage B cell development" RELATED [GOC:add]
synonym: "transitional two stage B lymphocyte differentiation" EXACT []
synonym: "transitional two stage B-cell differentiation" EXACT []
synonym: "transitional two stage B-lymphocyte differentiation" EXACT []
is_a: GO:0002332 ! transitional stage B cell differentiation

[Term]
id: GO:0002335
name: mature B cell differentiation
namespace: biological_process
def: "The process in which transitional stage B cells acquire the specialized features of mature B cells in the spleen." [GOC:jal, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "mature B lymphocyte differentiation" EXACT []
synonym: "mature B-cell differentiation" EXACT []
synonym: "mature B-lymphocyte differentiation" EXACT []
synonym: "mature cell development" RELATED [GOC:add]
is_a: GO:0030183 ! B cell differentiation

[Term]
id: GO:0002336
name: B-1 B cell lineage commitment
namespace: biological_process
def: "The process in which an immature B cell becomes committed to become a B-1 B cell." [GOC:jal, ISBN:0781735149]
synonym: "B-1 B lymphocyte lineage commitment" EXACT []
synonym: "B-1 B-cell lineage commitment" EXACT []
synonym: "B-1 B-lymphocyte lineage commitment" EXACT []
is_a: GO:0002326 ! B cell lineage commitment
relationship: part_of GO:0001923 ! B-1 B cell differentiation

[Term]
id: GO:0002337
name: B-1a B cell differentiation
namespace: biological_process
def: "The process in which B cells acquire the specialized features of B-1a B cells. B-1a B cells are B-1 cells that express CD5 and arise from fetal liver precursors." [GOC:jal, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "B-1a B cell development" RELATED [GOC:add]
synonym: "B-1a B lymphocyte differentiation" EXACT []
synonym: "B-1a B-cell differentiation" EXACT []
synonym: "B-1a B-lymphocyte differentiation" EXACT []
is_a: GO:0001923 ! B-1 B cell differentiation

[Term]
id: GO:0002338
name: B-1b B cell differentiation
namespace: biological_process
def: "The process in which B cells acquire the specialized features of B-1b B cells. B-1b B cells are B-1 cells that do not express CD5." [GOC:jal, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "B-1b B cell development" RELATED [GOC:add]
synonym: "B-1b B lymphocyte differentiation" EXACT []
synonym: "B-1b B-cell differentiation" EXACT []
synonym: "B-1b B-lymphocyte differentiation" EXACT []
is_a: GO:0001923 ! B-1 B cell differentiation

[Term]
id: GO:0002339
name: B cell selection
namespace: biological_process
def: "The process dependent upon B cell antigen receptor signaling in response to self or foreign antigen through which B cells are selected for survival." [GOC:jal]
synonym: "B lymphocyte selection" EXACT []
synonym: "B-cell selection" EXACT []
synonym: "B-lymphocyte selection" EXACT []
is_a: GO:0002376 ! immune system process
relationship: part_of GO:0030183 ! B cell differentiation

[Term]
id: GO:0002340
name: central B cell selection
namespace: biological_process
def: "Any B cell selection process that occurs in the bone marrow." [GOC:jal]
synonym: "central B lymphocyte selection" EXACT []
synonym: "central B-cell selection" EXACT []
synonym: "central B-lymphocyte selection" EXACT []
is_a: GO:0002339 ! B cell selection

[Term]
id: GO:0002341
name: central B cell anergy
namespace: biological_process
def: "Any process contributing to anergy, a state of functional inactivation that occurs as part of tolerance induction, in B cells in the bone marrow." [GOC:jal]
synonym: "central B lymphocyte anergy" EXACT []
synonym: "central B-cell anergy" EXACT []
synonym: "central B-lymphocyte anergy" EXACT []
is_a: GO:0002515 ! B cell anergy
relationship: part_of GO:0002340 ! central B cell selection
relationship: part_of GO:0002510 ! central B cell tolerance induction

[Term]
id: GO:0002342
name: central B cell deletion
namespace: biological_process
def: "The deletion of B cells by apoptotic process occurring as part of central tolerance induction and B cell selection." [GOC:add, GOC:jal, GOC:mtg_apoptosis]
synonym: "central B lymphocyte deletion" EXACT []
synonym: "central B-cell deletion" EXACT []
synonym: "central B-lymphocyte deletion" EXACT []
is_a: GO:0002516 ! B cell deletion
relationship: part_of GO:0002340 ! central B cell selection
relationship: part_of GO:0002510 ! central B cell tolerance induction

[Term]
id: GO:0002343
name: peripheral B cell selection
namespace: biological_process
def: "Any B cell selection process that occurs in the periphery." [GOC:jal]
synonym: "peripheral B lymphocyte selection" EXACT []
synonym: "peripheral B-cell selection" EXACT []
synonym: "peripheral B-lymphocyte selection" EXACT []
is_a: GO:0002339 ! B cell selection

[Term]
id: GO:0002344
name: B cell affinity maturation
namespace: biological_process
def: "The process in which B cells produce antibodies with increased antigen affinity. This is accomplished by somatic hypermutation and selection for B cells which produce higher affinity antibodies to antigen." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
synonym: "B lymphocyte affinity maturation" EXACT []
synonym: "B-cell affinity maturation" EXACT []
synonym: "B-lymphocyte affinity maturation" EXACT []
is_a: GO:0002343 ! peripheral B cell selection
relationship: part_of GO:0002381 ! immunoglobulin production involved in immunoglobulin mediated immune response

[Term]
id: GO:0002345
name: peripheral B cell receptor editing
namespace: biological_process
def: "The process that takes place mainly in germinal center B cells in which a large number of mutations are generated in the heavy chain and light chain V-region genes and their immediately surrounding introns in order to increase antibody diversity and contribute to affinity maturation." [GOC:jal]
synonym: "peripheral B lymphocyte receptor editing" EXACT []
synonym: "peripheral B-cell receptor editing" EXACT []
synonym: "peripheral B-lymphocyte receptor editing" EXACT []
is_a: GO:0002452 ! B cell receptor editing

[Term]
id: GO:0002346
name: B cell positive selection
namespace: biological_process
def: "Any process in which B cells are selected to survive based on signaling through the B cell antigen receptor." [GOC:jal]
synonym: "B lymphocyte positive selection" EXACT []
synonym: "B-cell positive selection" EXACT []
synonym: "B-lymphocyte positive selection" EXACT []
is_a: GO:0002339 ! B cell selection

[Term]
id: GO:0002347
name: response to tumor cell
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a tumor cell." [GOC:add, ISBN:0781735149, PMID:16730260]
is_a: GO:0009607 ! response to biotic stimulus

[Term]
id: GO:0002348
name: central B cell positive selection
namespace: biological_process
def: "Any process leading to positive selection of B cells in the bone marrow. Positive selection is the process in which B or T cells are selected to survive based on signaling through their antigen receptors." [GOC:jal]
synonym: "central B lymphocyte positive selection" EXACT []
synonym: "central B-cell positive selection" EXACT []
synonym: "central B-lymphocyte positive selection" EXACT []
is_a: GO:0002340 ! central B cell selection
is_a: GO:0002346 ! B cell positive selection

[Term]
id: GO:0002349
name: histamine production involved in inflammatory response
namespace: biological_process
def: "The synthesis or release of histamine following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:16730260]
synonym: "histamine production involved in acute inflammatory response" BROAD []
is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response

[Term]
id: GO:0002350
name: peripheral B cell positive selection
namespace: biological_process
def: "Any process leading to positive selection of B cells in the periphery. Positive selection is the process in which B or T cells are selected to survive based on signaling through their antigen receptors." [GOC:jal]
synonym: "peripheral B lymphocyte positive selection" EXACT []
synonym: "peripheral B-cell positive selection" EXACT []
synonym: "peripheral B-lymphocyte positive selection" EXACT []
is_a: GO:0002343 ! peripheral B cell selection
is_a: GO:0002346 ! B cell positive selection

[Term]
id: GO:0002351
name: serotonin production involved in inflammatory response
namespace: biological_process
def: "The synthesis or release of serotonin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:16730260]
synonym: "serotonin production involved in acute inflammatory response" BROAD []
is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response

[Term]
id: GO:0002352
name: B cell negative selection
namespace: biological_process
def: "Any process leading to negative selection in B cells. Mechanisms of negative selection include anergy and deletion." [GOC:jal]
synonym: "B lymphocyte negative selection" EXACT []
synonym: "B-cell negative selection" EXACT []
synonym: "B-lymphocyte negative selection" EXACT []
is_a: GO:0002339 ! B cell selection

[Term]
id: GO:0002353
name: plasma kallikrein-kinin cascade
namespace: biological_process
def: "A series of reactions that takes place outside the cell occurring in response to tissue damage and initiated within blood plasma by the action of activated Factor XII (Hageman Factor) on prekallikrein to convert it to plasma kallikrein, and the subsequent reaction of plasma kallikrein with high molecular weight kininogen. The ultimate product of the plasma kallikrein-kinin cascade is bradykinin, an agent known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability." [GOC:add, ISBN:0721601871, PMID:11842287, PMID:14501145]
is_a: GO:0002254 ! kinin cascade

[Term]
id: GO:0002354
name: central B cell negative selection
namespace: biological_process
def: "Any process leading to negative selection of B cells in the bone marrow." [GOC:jal]
synonym: "central B lymphocyte negative selection" EXACT []
synonym: "central B-cell negative selection" EXACT []
synonym: "central B-lymphocyte negative selection" EXACT []
is_a: GO:0002340 ! central B cell selection
is_a: GO:0002352 ! B cell negative selection

[Term]
id: GO:0002355
name: detection of tumor cell
namespace: biological_process
def: "The series of events in which a stimulus from a tumor cell is received and converted into a molecular signal." [GOC:add, ISBN:0781735149, PMID:16730260]
is_a: GO:0002347 ! response to tumor cell
is_a: GO:0009595 ! detection of biotic stimulus

[Term]
id: GO:0002356
name: peripheral B cell negative selection
namespace: biological_process
def: "Any process leading to negative selection of B cells in the periphery." [GOC:jal]
synonym: "peripheral B lymphocyte negative selection" EXACT []
synonym: "peripheral B-cell negative selection" EXACT []
synonym: "peripheral B-lymphocyte negative selection" EXACT []
is_a: GO:0002343 ! peripheral B cell selection
is_a: GO:0002352 ! B cell negative selection

[Term]
id: GO:0002357
name: defense response to tumor cell
namespace: biological_process
def: "Reactions triggered in response to the presence of a tumor cell that act to protect the cell or organism." [GOC:add, ISBN:0781735149, PMID:16730260]
is_a: GO:0002347 ! response to tumor cell
is_a: GO:0006952 ! defense response

[Term]
id: GO:0002358
name: B cell homeostatic proliferation
namespace: biological_process
def: "The non-specific expansion of B cell populations within a whole or part of an organism to reach to a total number of B cells which will then remain stable over time in the absence of an external stimulus." [GOC:jal]
synonym: "B lymphocyte homeostatic proliferation" EXACT []
synonym: "B-cell homeostatic proliferation" EXACT []
synonym: "B-lymphocyte homeostatic proliferation" EXACT []
is_a: GO:0042100 ! B cell proliferation
relationship: part_of GO:0042592 ! homeostatic process

[Term]
id: GO:0002359
name: B-1 B cell proliferation
namespace: biological_process
def: "The expansion of a B-1 B cell by cell division. Follows B cell activation." [GOC:jal]
synonym: "B-1 B lymphocyte proliferation" EXACT []
synonym: "B-1 B-cell proliferation" EXACT []
synonym: "B-1 B-lymphocyte proliferation" EXACT []
is_a: GO:0042100 ! B cell proliferation

[Term]
id: GO:0002360
name: T cell lineage commitment
namespace: biological_process
def: "The process in which a lymphoid progenitor cell becomes committed to becoming any type of T cell." [GOC:add, ISBN:0781735149]
synonym: "T lymphocyte lineage commitment" EXACT []
synonym: "T-cell lineage commitment" EXACT []
synonym: "T-lymphocyte lineage commitment" EXACT []
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0030217 ! T cell differentiation

[Term]
id: GO:0002361
name: CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell." [GOC:add, PMID:15207821]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T cell development" RELATED [GOC:add]
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation" EXACT []
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation" EXACT []
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation" EXACT []
is_a: GO:0043367 ! CD4-positive, alpha-beta T cell differentiation
is_a: GO:0045066 ! regulatory T cell differentiation

[Term]
id: GO:0002362
name: CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment
namespace: biological_process
def: "The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a CD4-positive, CD25-positive, alpha-beta regulatory T cell." [GOC:add, PMID:15207821]
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte lineage commitment" EXACT []
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-cell lineage commitment" EXACT []
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte lineage commitment" EXACT []
is_a: GO:0043373 ! CD4-positive, alpha-beta T cell lineage commitment
relationship: part_of GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

[Term]
id: GO:0002363
name: alpha-beta T cell lineage commitment
namespace: biological_process
def: "The process in which a pro-T cell becomes committed to becoming an alpha-beta T cell." [GOC:add, ISBN:0781735149]
synonym: "alpha-beta T lymphocyte lineage commitment" EXACT []
synonym: "alpha-beta T-cell lineage commitment" EXACT []
synonym: "alpha-beta T-lymphocyte lineage commitment" EXACT []
is_a: GO:0002360 ! T cell lineage commitment
relationship: part_of GO:0046632 ! alpha-beta T cell differentiation

[Term]
id: GO:0002364
name: NK T cell lineage commitment
namespace: biological_process
def: "The process in which a pro-T cell becomes committed to becoming an NK T cell." [GOC:add, ISBN:0781735149]
synonym: "natural killer T lymphocyte lineage commitment" EXACT []
synonym: "natural killer T-cell lineage commitment" EXACT []
synonym: "natural killer T-lymphocyte lineage commitment" EXACT []
synonym: "NK T lymphocyte lineage commitment" EXACT []
synonym: "NK T-cell lineage commitment" EXACT []
synonym: "NK T-lymphocyte lineage commitment" EXACT []
is_a: GO:0002363 ! alpha-beta T cell lineage commitment
relationship: part_of GO:0001865 ! NK T cell differentiation

[Term]
id: GO:0002365
name: gamma-delta T cell lineage commitment
namespace: biological_process
def: "The process in which a pro-T cell becomes committed to becoming a gamma-delta T cell." [GOC:add, ISBN:0781735149]
synonym: "gamma-delta T lymphocyte lineage commitment" EXACT []
synonym: "gamma-delta T-cell lineage commitment" EXACT []
synonym: "gamma-delta T-lymphocyte lineage commitment" EXACT []
is_a: GO:0002360 ! T cell lineage commitment
relationship: part_of GO:0042492 ! gamma-delta T cell differentiation

[Term]
id: GO:0002366
name: leukocyte activation involved in immune response
namespace: biological_process
def: "A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "immune cell activation during immune response" RELATED []
synonym: "leucocyte activation during immune response" RELATED []
synonym: "leukocyte activation during immune response" RELATED [GOC:tb]
is_a: GO:0002263 ! cell activation involved in immune response
is_a: GO:0045321 ! leukocyte activation
intersection_of: GO:0045321 ! leukocyte activation
intersection_of: part_of GO:0006955 ! immune response
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0002367
name: cytokine production involved in immune response
namespace: biological_process
def: "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022. Note that this term is intended for use when a gene product is seen to cause apparent increases in intracellular or extracellular cytokine levels, without specific regard as to whether the increase is due to increased biosynthesis, increased secretion of preexisting cytokine molecules, or increased conversion from precursor molecules.
synonym: "cytokine production during immune response" RELATED [GOC:dph]
is_a: GO:0001816 ! cytokine production
is_a: GO:0002440 ! production of molecular mediator of immune response
intersection_of: GO:0001816 ! cytokine production
intersection_of: part_of GO:0006955 ! immune response
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0002368
name: B cell cytokine production
namespace: biological_process
def: "Any process that contributes to cytokine production by a B cell." [GOC:add, ISBN:0781735149]
synonym: "B lymphocyte cytokine production" EXACT []
synonym: "B-cell cytokine production" EXACT []
synonym: "B-lymphocyte cytokine production" EXACT []
is_a: GO:0002367 ! cytokine production involved in immune response
is_a: GO:0019724 ! B cell mediated immunity

[Term]
id: GO:0002369
name: T cell cytokine production
namespace: biological_process
def: "Any process that contributes to cytokine production by a T cell." [GOC:add, ISBN:0781735149]
synonym: "T lymphocyte cytokine production" EXACT []
synonym: "T-cell cytokine production" EXACT []
synonym: "T-lymphocyte cytokine production" EXACT []
is_a: GO:0002367 ! cytokine production involved in immune response
is_a: GO:0002456 ! T cell mediated immunity

[Term]
id: GO:0002370
name: natural killer cell cytokine production
namespace: biological_process
def: "Any process that contributes to cytokine production by a natural killer cell." [GOC:add, ISBN:0781735149]
synonym: "NK cell cytokine production" EXACT []
is_a: GO:0002228 ! natural killer cell mediated immunity
is_a: GO:0002367 ! cytokine production involved in immune response

[Term]
id: GO:0002371
name: dendritic cell cytokine production
namespace: biological_process
def: "Any process that contributes to cytokine production by a dendritic cell." [GOC:add, ISBN:0781735149]
is_a: GO:0002367 ! cytokine production involved in immune response
is_a: GO:0002443 ! leukocyte mediated immunity

[Term]
id: GO:0002372
name: myeloid dendritic cell cytokine production
namespace: biological_process
def: "Any process that contributes to cytokine production by a myeloid dendritic cell." [GOC:add, ISBN:0781735149]
is_a: GO:0002371 ! dendritic cell cytokine production
is_a: GO:0002444 ! myeloid leukocyte mediated immunity
is_a: GO:0061082 ! myeloid leukocyte cytokine production

[Term]
id: GO:0002373
name: plasmacytoid dendritic cell cytokine production
namespace: biological_process
def: "Any process that contributes to cytokine production by a plasmacytoid dendritic cell." [GOC:add, ISBN:0781735149]
is_a: GO:0002371 ! dendritic cell cytokine production

[Term]
id: GO:0002374
name: cytokine secretion involved in immune response
namespace: biological_process
def: "The regulated release of cytokines from a cell that contributes to an immune response." [GOC:add, ISBN:0781735149]
synonym: "cytokine secretion during immune response" RELATED [GOC:dph]
is_a: GO:0050663 ! cytokine secretion
intersection_of: GO:0050663 ! cytokine secretion
intersection_of: part_of GO:0006955 ! immune response
relationship: part_of GO:0002367 ! cytokine production involved in immune response
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0002375
name: cytokine biosynthetic process involved in immune response
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a cytokine that contributes to an immune response." [GOC:add, ISBN:0781735149]
synonym: "cytokine biosynthetic process during immune response" RELATED [GOC:dph]
is_a: GO:0042089 ! cytokine biosynthetic process
intersection_of: GO:0042089 ! cytokine biosynthetic process
intersection_of: part_of GO:0006955 ! immune response
relationship: part_of GO:0002367 ! cytokine production involved in immune response
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0002376
name: immune system process
namespace: biological_process
def: "Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
comment: Note that this term is a direct child of 'biological_process ; GO:0008150' because some immune system processes are types of cellular process (GO:0009987), whereas others are types of multicellular organism process (GO:0032501). This term was added by GO_REF:0000022.
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
xref: Wikipedia:Immune_system
is_a: GO:0008150 ! biological_process
disjoint_from: GO:0044848 ! biological phase

[Term]
id: GO:0002377
name: immunoglobulin production
namespace: biological_process
def: "The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149]
synonym: "antibody production" EXACT []
is_a: GO:0002440 ! production of molecular mediator of immune response

[Term]
id: GO:0002378
name: immunoglobulin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of immunoglobulin." [GOC:add, ISBN:0781735149]
synonym: "antibody biosynthesis" EXACT []
synonym: "antibody biosynthetic process" EXACT []
is_a: GO:0009059 ! macromolecule biosynthetic process
relationship: part_of GO:0002377 ! immunoglobulin production

[Term]
id: GO:0002379
name: immunoglobulin biosynthetic process involved in immune response
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of immunoglobulin contributing to an immune response." [GOC:add, ISBN:0781735149]
synonym: "antibody biosynthesis during immune response" RELATED []
synonym: "antibody biosynthetic process during immune response" RELATED []
synonym: "immunoglobulin biosynthetic process during immune response" RELATED [GOC:dph]
is_a: GO:0002378 ! immunoglobulin biosynthetic process
intersection_of: GO:0002378 ! immunoglobulin biosynthetic process
intersection_of: part_of GO:0002381 ! immunoglobulin production involved in immunoglobulin mediated immune response
relationship: part_of GO:0002381 ! immunoglobulin production involved in immunoglobulin mediated immune response

[Term]
id: GO:0002380
name: immunoglobulin secretion involved in immune response
namespace: biological_process
def: "The regulated release of immunoglobulins from a B cell or plasma cell contributing to an immune response." [GOC:add, ISBN:0781735149, PMID:9185563]
synonym: "antibody secretion during immune response" RELATED []
synonym: "immunoglobulin secretion during immune response" RELATED [goc:dph]
is_a: GO:0048305 ! immunoglobulin secretion
intersection_of: GO:0048305 ! immunoglobulin secretion
intersection_of: part_of GO:0002381 ! immunoglobulin production involved in immunoglobulin mediated immune response
relationship: part_of GO:0002381 ! immunoglobulin production involved in immunoglobulin mediated immune response

[Term]
id: GO:0002381
name: immunoglobulin production involved in immunoglobulin mediated immune response
namespace: biological_process
def: "The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149]
synonym: "antibody production during immune response" RELATED []
synonym: "immunoglobulin production during immune response" RELATED [GOC:dph]
synonym: "immunoglobulin production involved in immune response" RELATED [GOC:dph]
is_a: GO:0002377 ! immunoglobulin production
intersection_of: GO:0002377 ! immunoglobulin production
intersection_of: part_of GO:0016064 ! immunoglobulin mediated immune response
relationship: part_of GO:0016064 ! immunoglobulin mediated immune response

[Term]
id: GO:0002382
name: regulation of tissue kallikrein-kinin cascade
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the tissue kallikrein-kinin cascade." [GOC:add]
synonym: "regulation of glandular kallikrein-kinin cascade" EXACT []
is_a: GO:0002256 ! regulation of kinin cascade
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002255 ! tissue kallikrein-kinin cascade
relationship: regulates GO:0002255 ! tissue kallikrein-kinin cascade

[Term]
id: GO:0002383
name: immune response in brain or nervous system
namespace: biological_process
def: "An immune response taking place in the brain or nervous system." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002251 ! organ or tissue specific immune response

[Term]
id: GO:0002384
name: hepatic immune response
namespace: biological_process
def: "An immune response taking place in the liver." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002251 ! organ or tissue specific immune response

[Term]
id: GO:0002385
name: mucosal immune response
namespace: biological_process
def: "An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002251 ! organ or tissue specific immune response

[Term]
id: GO:0002386
name: immune response in mucosal-associated lymphoid tissue
namespace: biological_process
def: "Immune response taking place in the mucosal-associated lymphoid tissue (MALT). Mucosal-associated lymphoid tissue is typically found as nodules associated with mucosal epithelia with distinct internal structures including B- and T-zones for the activation of lymphocytes." [GOC:jal, ISBN:0781735149]
synonym: "immune response in MALT" EXACT []
is_a: GO:0002385 ! mucosal immune response

[Term]
id: GO:0002387
name: immune response in gut-associated lymphoid tissue
namespace: biological_process
def: "Immune response taking place in the gut-associated lymphoid tissue (GALT). GALT includes Peyer's patches, appendix, and solitary lymph nodules." [GOC:jal, ISBN:0781735149]
synonym: "immune response in GALT" EXACT []
is_a: GO:0002386 ! immune response in mucosal-associated lymphoid tissue

[Term]
id: GO:0002388
name: immune response in Peyer's patch
namespace: biological_process
def: "Immune response taking place in the Peyer's patch, nodular lymphoid structures on the serosal surface of the small intestine." [GOC:jal, ISBN:0781735149]
is_a: GO:0002387 ! immune response in gut-associated lymphoid tissue

[Term]
id: GO:0002389
name: tolerance induction in Peyer's patch
namespace: biological_process
def: "Tolerance induction taking place in the Peyer's patches." [GOC:jal, ISBN:0781735149]
is_a: GO:0002388 ! immune response in Peyer's patch
is_a: GO:0002394 ! tolerance induction in gut-associated lymphoid tissue

[Term]
id: GO:0002390
name: platelet activating factor production
namespace: biological_process
def: "The synthesis or release of platelet activating factor following a stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149]
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0002391
name: platelet activating factor production involved in inflammatory response
namespace: biological_process
def: "The synthesis or release of platelet activating factor following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149]
synonym: "platelet activating factor production involved in acute inflammatory response" BROAD []
is_a: GO:0002390 ! platelet activating factor production
is_a: GO:0002534 ! cytokine production involved in inflammatory response
intersection_of: GO:0002390 ! platelet activating factor production
intersection_of: part_of GO:0006954 ! inflammatory response
relationship: part_of GO:0006954 ! inflammatory response

[Term]
id: GO:0002392
name: platelet activating factor secretion
namespace: biological_process
def: "The regulated release of platelet activating factor by a cell." [GOC:add, ISBN:0781735149]
is_a: GO:0015696 ! ammonium transport
is_a: GO:0015697 ! quaternary ammonium group transport
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0015914 ! phospholipid transport
is_a: GO:0050663 ! cytokine secretion

[Term]
id: GO:0002393
name: lysosomal enzyme production involved in inflammatory response
namespace: biological_process
def: "The synthesis or release of lysosomal enzymes following a stimulus as part of a inflammatory response, resulting in an increase in intracellular or extracellular levels." [GOC:add]
synonym: "lysosomal enzyme production involved in acute inflammatory response" BROAD [GOC:mah]
synonym: "production of lysosomal enzymes involved in acute inflammatory response" BROAD []
synonym: "production of lysosomal enzymes involved in inflammatory response" EXACT [GOC:curators]
is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response

[Term]
id: GO:0002394
name: tolerance induction in gut-associated lymphoid tissue
namespace: biological_process
def: "Tolerance induction taking place in the gut-associated lymphoid tissue (GALT)." [GOC:jal, ISBN:0781735149]
synonym: "oral tolerance" RELATED []
synonym: "tolerance induction in GALT" EXACT []
is_a: GO:0002387 ! immune response in gut-associated lymphoid tissue
is_a: GO:0002401 ! tolerance induction in mucosal-associated lymphoid tissue

[Term]
id: GO:0002395
name: immune response in nasopharyngeal-associated lymphoid tissue
namespace: biological_process
def: "An immune response taking place in the nasopharyngeal-associated lymphoid tissue (NALT). NALT includes the tonsils and adenoids." [GOC:jal, ISBN:0781735149]
synonym: "immune response in NALT" EXACT []
is_a: GO:0002387 ! immune response in gut-associated lymphoid tissue

[Term]
id: GO:0002396
name: MHC protein complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591, PMID:15928678]
is_a: GO:0043623 ! cellular protein complex assembly

[Term]
id: GO:0002397
name: MHC class I protein complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an MHC class I protein complex. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:15771591]
is_a: GO:0002396 ! MHC protein complex assembly

[Term]
id: GO:0002398
name: MHC class Ib protein complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules." [GOC:add, PMID:15928678, PMID:15928680]
is_a: GO:0002396 ! MHC protein complex assembly

[Term]
id: GO:0002399
name: MHC class II protein complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an MHC class II protein complex." [GOC:add, ISBN:0781735149, PMID:15771591]
is_a: GO:0002396 ! MHC protein complex assembly

[Term]
id: GO:0002400
name: tolerance induction in nasopharyngeal-associated lymphoid tissue
namespace: biological_process
def: "Tolerance induction taking place in the nasopharyngeal-associated lymphoid tissue (NALT)." [GOC:jal, ISBN:0781735149]
synonym: "nasal tolerance" RELATED []
synonym: "tolerance induction in NALT" EXACT []
is_a: GO:0002394 ! tolerance induction in gut-associated lymphoid tissue
is_a: GO:0002395 ! immune response in nasopharyngeal-associated lymphoid tissue

[Term]
id: GO:0002401
name: tolerance induction in mucosal-associated lymphoid tissue
namespace: biological_process
def: "Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT)." [GOC:jal, ISBN:0781735149]
synonym: "tolerance induction in MALT" EXACT []
is_a: GO:0002386 ! immune response in mucosal-associated lymphoid tissue
is_a: GO:0002427 ! mucosal tolerance induction

[Term]
id: GO:0002402
name: B cell tolerance induction in mucosal-associated lymphoid tissue
namespace: biological_process
def: "Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT) mediated by B cells." [GOC:jal, ISBN:0781735149]
synonym: "B cell tolerance induction in MALT" EXACT []
is_a: GO:0002401 ! tolerance induction in mucosal-associated lymphoid tissue
is_a: GO:0002451 ! peripheral B cell tolerance induction

[Term]
id: GO:0002403
name: T cell tolerance induction in mucosal-associated lymphoid tissue
namespace: biological_process
def: "Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT) mediated by T cells." [GOC:jal, ISBN:0781735149, PMID:16551263]
synonym: "T cell tolerance induction in MALT" EXACT []
is_a: GO:0002401 ! tolerance induction in mucosal-associated lymphoid tissue
is_a: GO:0002458 ! peripheral T cell tolerance induction

[Term]
id: GO:0002404
name: antigen sampling in mucosal-associated lymphoid tissue
namespace: biological_process
def: "The process of apical-to-basolateral delivery of soluble and particulate antigens to underlying mucosal-associated lymphoid tissue." [GOC:jal, PMID:11896763, PMID:12843411, PMID:15681746]
synonym: "antigen sampling in MALT" EXACT []
synonym: "antigen transport in MALT" RELATED []
synonym: "antigen transport in mucosal-associated lymphoid tissue" RELATED []
is_a: GO:0002376 ! immune system process
relationship: part_of GO:0002386 ! immune response in mucosal-associated lymphoid tissue

[Term]
id: GO:0002405
name: antigen sampling by dendritic cells in mucosal-associated lymphoid tissue
namespace: biological_process
def: "The process of antigen sampling carried out by dendritic cells in the mucosal-associated lymphoid tissue." [GOC:jal, PMID:11896763, PMID:15681746]
synonym: "antigen sampling by dendritic cells in MALT" EXACT []
is_a: GO:0002404 ! antigen sampling in mucosal-associated lymphoid tissue
relationship: part_of GO:0002468 ! dendritic cell antigen processing and presentation

[Term]
id: GO:0002406
name: antigen sampling by M cells in mucosal-associated lymphoid tissue
namespace: biological_process
def: "The process of antigen samples carried out by M cells in the mucosal-associated lymphoid tissue." [GOC:jal, PMID:11896763]
synonym: "antigen sampling by M cells in MALT" EXACT []
is_a: GO:0002404 ! antigen sampling in mucosal-associated lymphoid tissue

[Term]
id: GO:0002407
name: dendritic cell chemotaxis
namespace: biological_process
def: "The movement of a dendritic cell in response to an external stimulus." [CL:0000451, GOC:add, ISBN:0781735149, PMID:15814331, PMID:16056255]
is_a: GO:0030595 ! leukocyte chemotaxis
is_a: GO:0036336 ! dendritic cell migration

[Term]
id: GO:0002408
name: myeloid dendritic cell chemotaxis
namespace: biological_process
def: "The movement of a myeloid dendritic cell in response to an external stimulus." [GOC:add, ISBN:0781735149, PMID:15814331, PMID:16056255]
is_a: GO:0002407 ! dendritic cell chemotaxis
is_a: GO:0097529 ! myeloid leukocyte migration

[Term]
id: GO:0002409
name: Langerhans cell chemotaxis
namespace: biological_process
def: "The movement of a Langerhans cell in response to an external stimulus." [GOC:add, PMID:16056255, PMID:16387601]
is_a: GO:0002408 ! myeloid dendritic cell chemotaxis

[Term]
id: GO:0002410
name: plasmacytoid dendritic cell chemotaxis
namespace: biological_process
def: "The movement of a plasmacytoid dendritic cell in response to an external stimulus." [GOC:add, PMID:15159375, PMID:15814331]
is_a: GO:0002407 ! dendritic cell chemotaxis

[Term]
id: GO:0002411
name: T cell tolerance induction to tumor cell
namespace: biological_process
def: "A process of tolerance induction dependent on T cells which leads to immunological tolerance of a tumor." [GOC:add, ISBN:0781735149, PMID:16730260]
is_a: GO:0002413 ! tolerance induction to tumor cell
is_a: GO:0002424 ! T cell mediated immune response to tumor cell
is_a: GO:0002458 ! peripheral T cell tolerance induction

[Term]
id: GO:0002412
name: antigen transcytosis by M cells in mucosal-associated lymphoid tissue
namespace: biological_process
def: "The process of antigen transcytosis carried out by M cells in the mucosal-associated lymphoid tissue (MALT). Transcytosis is the process of the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. M cells are specialized epithelia cells with a microfold structure that are adept at moving antigens from the gut lumen to antigen presenting cells in the MALT." [GOC:jal, ISBN:0781735149, PMID:12843411]
synonym: "antigen transcytosis by M cells in MALT" EXACT []
synonym: "antigen transport by M cells in MALT" EXACT []
synonym: "antigen transport by M cells in mucosal-associated lymphoid tissue" EXACT []
is_a: GO:0045056 ! transcytosis
relationship: part_of GO:0002406 ! antigen sampling by M cells in mucosal-associated lymphoid tissue

[Term]
id: GO:0002413
name: tolerance induction to tumor cell
namespace: biological_process
def: "A process of tolerance induction which leads to immunological tolerance of a tumor." [GOC:add]
is_a: GO:0002418 ! immune response to tumor cell
is_a: GO:0002465 ! peripheral tolerance induction

[Term]
id: GO:0002414
name: immunoglobulin transcytosis in epithelial cells
namespace: biological_process
def: "The process of transporting immunoglobulin, via transcytosis, from one side of an epithelial cell to the other." [GOC:add, ISBN:0781735149, ISBN:081533642X, PMID:16048543]
is_a: GO:0045056 ! transcytosis

[Term]
id: GO:0002415
name: immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor
namespace: biological_process
def: "The process of transporting polymeric IgA and polymeric IgM immunoglobulin, via transcytosis mediated by the polymeric immunoglobulin receptor (pIgR), from the basolateral surface to apical surface of an epithelial cell. At the apical surface the immunoglobulin binding portion of the pIgRis cleaved and remains bound to the transported immunoglobulin as secretory component (SC). The same process is used for the transport and excretion of IgA immune complexes to the luminal surface of the mucosa." [GOC:add, ISBN:0781735149, ISBN:081533642X, PMID:16048543]
synonym: "antibody transcytosis mediated by pIgR" EXACT []
synonym: "immunoglobulin transcytosis mediated by pIgR" EXACT []
is_a: GO:0002414 ! immunoglobulin transcytosis in epithelial cells
relationship: part_of GO:0002386 ! immune response in mucosal-associated lymphoid tissue

[Term]
id: GO:0002416
name: IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor
namespace: biological_process
def: "The process of transporting IgG immunoglobulin, via transcytosis using the FcRn (also known as the neonatal Fc receptor; gene name FCGRT), from apical surface of an epithelial cell to the basolateral surface or vice versa depending on the location. This process is used for uptake of IgG from the milk in the gut in rodents, for transplacental transport of IgG from mother to embryo in humans, and for maintenance of a steady-state distribution of IgG across epithelial boundaries in general in adult mammals." [GOC:add, ISBN:0781735149, ISBN:081533642X]
synonym: "IgG antibody transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor" EXACT []
synonym: "IgG immunoglobulin transcytosis in epithelial cells mediated by neonatal immunoglobulin receptor" EXACT []
is_a: GO:0002414 ! immunoglobulin transcytosis in epithelial cells

[Term]
id: GO:0002417
name: B cell antigen processing and presentation mediated by B cell receptor uptake of antigen
namespace: biological_process
def: "B cell antigen processing and presentation which is initiated by uptake of antigen bound to the B cell receptor." [GOC:add, ISBN:0781735149, PMID:15771591]
synonym: "B lymphocyte antigen processing and presentation mediated by B cell receptor uptake of antigen" EXACT []
synonym: "B-cell antigen processing and presentation mediated by B cell receptor uptake of antigen" EXACT []
synonym: "B-lymphocyte antigen processing and presentation mediated by B cell receptor uptake of antigen" EXACT []
is_a: GO:0002450 ! B cell antigen processing and presentation
is_a: GO:0002751 ! antigen processing and presentation following receptor mediated endocytosis

[Term]
id: GO:0002418
name: immune response to tumor cell
namespace: biological_process
def: "An immune system process that functions in the response of an organism to a tumor cell." [GOC:add, ISBN:0781735149, PMID:16730260]
is_a: GO:0002347 ! response to tumor cell
is_a: GO:0006955 ! immune response

[Term]
id: GO:0002419
name: T cell mediated cytotoxicity directed against tumor cell target
namespace: biological_process
def: "The directed killing of a tumor cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors." [GOC:add, ISBN:0781735149, PMID:16730260]
comment: Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell.
synonym: "T lymphocyte mediated cytotoxicity directed against tumor cell target" EXACT []
synonym: "T-cell mediated cytotoxicity directed against tumor cell target" EXACT []
synonym: "T-lymphocyte mediated cytotoxicity directed against tumor cell target" EXACT []
is_a: GO:0001913 ! T cell mediated cytotoxicity
is_a: GO:0002424 ! T cell mediated immune response to tumor cell

[Term]
id: GO:0002420
name: natural killer cell mediated cytotoxicity directed against tumor cell target
namespace: biological_process
def: "The directed killing of a tumor cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors." [GOC:add, ISBN:0781735149, PMID:16730260]
comment: Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell.
synonym: "NK cell mediated cytotoxicity directed against tumor cell target" EXACT []
is_a: GO:0002423 ! natural killer cell mediated immune response to tumor cell
is_a: GO:0042267 ! natural killer cell mediated cytotoxicity

[Term]
id: GO:0002421
name: B cell antigen processing and presentation following pinocytosis
namespace: biological_process
def: "B cell antigen processing and presentation which is initiated by uptake of antigen via pinocytosis." [GOC:add, PMID:7543530]
synonym: "B lymphocyte antigen processing and presentation following pinocytosis" EXACT []
synonym: "B-cell antigen processing and presentation following pinocytosis" EXACT []
synonym: "B-lymphocyte antigen processing and presentation following pinocytosis" EXACT []
is_a: GO:0002450 ! B cell antigen processing and presentation
is_a: GO:0002746 ! antigen processing and presentation following pinocytosis

[Term]
id: GO:0002422
name: immune response in urogenital tract
namespace: biological_process
def: "An immune response taking place in the urogenital tract. The urogenital tract." [GOC:jal]
is_a: GO:0002385 ! mucosal immune response

[Term]
id: GO:0002423
name: natural killer cell mediated immune response to tumor cell
namespace: biological_process
def: "An immune response mediated by a natural killer cell triggered in response to the presence of a tumor cell." [GOC:add, ISBN:0781735149, PMID:16730260]
is_a: GO:0002228 ! natural killer cell mediated immunity
is_a: GO:0002418 ! immune response to tumor cell

[Term]
id: GO:0002424
name: T cell mediated immune response to tumor cell
namespace: biological_process
def: "An immune response mediated by a T cell triggered in response to the presence of a tumor cell." [GOC:add, ISBN:0781735149, PMID:16730260]
comment: Note that this term includes tolerogenic responses to tumor cells mediated by responding T cells.
is_a: GO:0002418 ! immune response to tumor cell
is_a: GO:0002456 ! T cell mediated immunity

[Term]
id: GO:0002425
name: tolerance induction in urogenital tract
namespace: biological_process
def: "Tolerance induction taking place in the urogenital tract." [GOC:jal]
is_a: GO:0002422 ! immune response in urogenital tract
is_a: GO:0002427 ! mucosal tolerance induction

[Term]
id: GO:0002426
name: immunoglobulin production in mucosal tissue
namespace: biological_process
def: "The synthesis and release of immunoglobulin in the mucosal tissue." [GOC:jal]
synonym: "antibody production in mucosal tissue" EXACT []
is_a: GO:0002381 ! immunoglobulin production involved in immunoglobulin mediated immune response
relationship: part_of GO:0002385 ! mucosal immune response

[Term]
id: GO:0002427
name: mucosal tolerance induction
namespace: biological_process
def: "Tolerance induction taking place in the mucosal tissues." [GOC:jal]
is_a: GO:0002385 ! mucosal immune response
is_a: GO:0002462 ! tolerance induction to nonself antigen

[Term]
id: GO:0002428
name: antigen processing and presentation of peptide antigen via MHC class Ib
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses peptide antigen in association with an MHC class Ib protein complex on its cell surface. The peptide antigen may originate from an endogenous or exogenous protein. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E family." [GOC:add, PMID:15928678]
synonym: "peptide antigen processing and presentation via MHC class Ib" EXACT []
is_a: GO:0002475 ! antigen processing and presentation via MHC class Ib
is_a: GO:0048002 ! antigen processing and presentation of peptide antigen

[Term]
id: GO:0002429
name: immune response-activating cell surface receptor signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a cell capable of activating or perpetuating an immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
synonym: "activation of immune response by cell surface receptor signaling pathway" EXACT []
synonym: "immune response-activating cell surface receptor signalling pathway" EXACT []
is_a: GO:0002757 ! immune response-activating signal transduction
is_a: GO:0002768 ! immune response-regulating cell surface receptor signaling pathway

[Term]
id: GO:0002430
name: complement receptor mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals generated as a consequence of a component of the complement pathway binding to a complement receptor. Such components include both whole complement proteins and fragments of complement proteins generated through the activity of the complement pathway." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
synonym: "complement receptor mediated signalling pathway" EXACT []
synonym: "immune response-regulating cell surface receptor signalling pathway" BROAD []
is_a: GO:0002429 ! immune response-activating cell surface receptor signaling pathway

[Term]
id: GO:0002431
name: Fc receptor mediated stimulatory signaling pathway
namespace: biological_process
def: "A series of molecular signals generated as a consequence of a the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of activating or perpetuating an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
synonym: "Fc receptor mediated stimulatory signalling pathway" EXACT []
synonym: "Fc-receptor mediated stimulatory signaling pathway" EXACT []
is_a: GO:0002429 ! immune response-activating cell surface receptor signaling pathway

[Term]
id: GO:0002432
name: granuloma formation
namespace: biological_process
def: "The formation of nodular inflammatory lesions, usually small or granular, firm, persistent, well-structured, and containing compactly grouped T lymphocytes and modified phagocytes such as epithelioid cells, giant cells, and other macrophages. Granuloma formation represents a chronic inflammatory response initiated by various infectious and noninfectious agents. The center of a granuloma consists of fused macrophages, which can become necrotic." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:068340007X, ISBN:0721601464, ISBN:081533642X]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002252 ! immune effector process
relationship: part_of GO:0002544 ! chronic inflammatory response

[Term]
id: GO:0002433
name: immune response-regulating cell surface receptor signaling pathway involved in phagocytosis
namespace: biological_process
def: "An immune response-regulating cell surface receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes." [GO_REF:0000022, GOC:add, GOC:bf, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
synonym: "immune response-regulating cell surface receptor signalling pathway involved in phagocytosis" EXACT [GOC:mah]
synonym: "phagocytosis triggered by activation of immune response cell surface activating receptor" EXACT [GO_REF:0000022]
is_a: GO:0002252 ! immune effector process
is_a: GO:0002768 ! immune response-regulating cell surface receptor signaling pathway
intersection_of: GO:0002768 ! immune response-regulating cell surface receptor signaling pathway
intersection_of: part_of GO:0006909 ! phagocytosis
relationship: part_of GO:0006909 ! phagocytosis

[Term]
id: GO:0002434
name: immune complex clearance
namespace: biological_process
def: "A process directed at removing immune complexes from the body. Immune complexes are clusters of antibodies bound to antigen, to which complement may also be fixed, and which may precipitate or remain in solution." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:068340007X]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002252 ! immune effector process

[Term]
id: GO:0002435
name: immune complex clearance by erythrocytes
namespace: biological_process
def: "The process of immune complex clearance by erythrocytes." [GOC:add, PMID:11414352]
synonym: "immune complex clearance by RBCs" EXACT [CL:0000232]
synonym: "immune complex clearance by red blood cells" EXACT [CL:0000232]
is_a: GO:0002434 ! immune complex clearance

[Term]
id: GO:0002436
name: immune complex clearance by monocytes and macrophages
namespace: biological_process
def: "The process of immune complex clearance by monocytes or macrophages." [GOC:add, ISBN:0781735149]
is_a: GO:0002434 ! immune complex clearance

[Term]
id: GO:0002437
name: inflammatory response to antigenic stimulus
namespace: biological_process
def: "An inflammatory response to an antigenic stimulus, which can be include any number of T cell or B cell epitopes." [GOC:add, ISBN:0781735149]
is_a: GO:0006954 ! inflammatory response
is_a: GO:0006955 ! immune response

[Term]
id: GO:0002438
name: acute inflammatory response to antigenic stimulus
namespace: biological_process
def: "An acute inflammatory response to an antigenic stimulus. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002437 ! inflammatory response to antigenic stimulus
is_a: GO:0002526 ! acute inflammatory response

[Term]
id: GO:0002439
name: chronic inflammatory response to antigenic stimulus
namespace: biological_process
def: "A chronic inflammatory response to an antigenic stimulus. A chronic inflammatory response persists indefinitely during days, weeks, or months in the life of an individual." [GOC:add, ISBN:0781735149]
is_a: GO:0002437 ! inflammatory response to antigenic stimulus
is_a: GO:0002544 ! chronic inflammatory response

[Term]
id: GO:0002440
name: production of molecular mediator of immune response
namespace: biological_process
def: "The synthesis or release of any molecular mediator of the immune response, resulting in an increase in its intracellular or extracellular levels." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
synonym: "production of cellular mediator of immune response" RELATED []
is_a: GO:0002376 ! immune system process

[Term]
id: GO:0002441
name: histamine secretion involved in inflammatory response
namespace: biological_process
def: "The regulated release of histamine by a cell as part of an inflammatory response." [GOC:add, ISBN:0781735149]
synonym: "histamine secretion involved in acute inflammatory response" BROAD []
is_a: GO:0001821 ! histamine secretion
is_a: GO:0046879 ! hormone secretion
intersection_of: GO:0001821 ! histamine secretion
intersection_of: part_of GO:0006954 ! inflammatory response
relationship: part_of GO:0002349 ! histamine production involved in inflammatory response
relationship: part_of GO:0006954 ! inflammatory response

[Term]
id: GO:0002442
name: serotonin secretion involved in inflammatory response
namespace: biological_process
def: "The regulated release of serotonin by a cell as part of an inflammatory response." [GOC:add, ISBN:0781735149]
synonym: "serotonin release involved in inflammatory response" RELATED [GOC:tb]
synonym: "serotonin secretion involved in acute inflammatory response" BROAD []
is_a: GO:0001820 ! serotonin secretion
intersection_of: GO:0001820 ! serotonin secretion
intersection_of: part_of GO:0006954 ! inflammatory response
relationship: part_of GO:0002351 ! serotonin production involved in inflammatory response
relationship: part_of GO:0006954 ! inflammatory response

[Term]
id: GO:0002443
name: leukocyte mediated immunity
namespace: biological_process
alt_id: GO:0019723
alt_id: GO:0042087
def: "Any process involved in the carrying out of an immune response by a leukocyte." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
synonym: "cell-mediated immune response" RELATED []
synonym: "cellular immune response" RELATED []
synonym: "immune cell effector process" EXACT []
synonym: "immune cell mediated immunity" EXACT []
synonym: "leucocyte immune effector process" EXACT []
synonym: "leucocyte mediated immunity" EXACT []
synonym: "leukocyte immune effector process" EXACT []
is_a: GO:0002252 ! immune effector process

[Term]
id: GO:0002444
name: myeloid leukocyte mediated immunity
namespace: biological_process
def: "Any process involved in the carrying out of an immune response by a myeloid leukocyte." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
synonym: "myeloid leucocyte immune effector process" EXACT []
synonym: "myeloid leucocyte mediated immunity" EXACT []
synonym: "myeloid leukocyte immune effector process" EXACT []
is_a: GO:0002443 ! leukocyte mediated immunity

[Term]
id: GO:0002445
name: type II hypersensitivity
namespace: biological_process
def: "An inflammatory response resulting in cell death or dysfunction mediated by activation of the classical complement pathway or induction of effector cell phagocytosis, cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell, or mediated by the direct binding of antibody to cellular receptors." [GOC:add, ISBN:0781735149]
xref: Wikipedia:Type_II_hypersensitivity
is_a: GO:0002444 ! myeloid leukocyte mediated immunity
is_a: GO:0002524 ! hypersensitivity
is_a: GO:0016064 ! immunoglobulin mediated immune response

[Term]
id: GO:0002446
name: neutrophil mediated immunity
namespace: biological_process
def: "Any process involved in the carrying out of an immune response by a neutrophil." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002444 ! myeloid leukocyte mediated immunity

[Term]
id: GO:0002447
name: eosinophil mediated immunity
namespace: biological_process
def: "Any process involved in the carrying out of an immune response by an eosinophil." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002444 ! myeloid leukocyte mediated immunity

[Term]
id: GO:0002448
name: mast cell mediated immunity
namespace: biological_process
def: "Any process involved in the carrying out of an immune response by a mast cell." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002444 ! myeloid leukocyte mediated immunity

[Term]
id: GO:0002449
name: lymphocyte mediated immunity
namespace: biological_process
def: "Any process involved in the carrying out of an immune response by a lymphocyte." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
synonym: "cell-mediated immunity" BROAD []
synonym: "cellular immune response" BROAD []
is_a: GO:0002443 ! leukocyte mediated immunity

[Term]
id: GO:0002450
name: B cell antigen processing and presentation
namespace: biological_process
def: "The process in which a B cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591]
synonym: "B lymphocyte antigen processing and presentation" EXACT []
synonym: "B-cell antigen processing and presentation" EXACT []
synonym: "B-lymphocyte antigen processing and presentation" EXACT []
is_a: GO:0019882 ! antigen processing and presentation
relationship: part_of GO:0019724 ! B cell mediated immunity

[Term]
id: GO:0002451
name: peripheral B cell tolerance induction
namespace: biological_process
def: "Tolerance induction of mature B cells in the peripheral lymphoid tissues: the blood, lymph nodes, spleen, and mucosal-associated lymphoid tissue." [GOC:jal, ISBN:0781735149]
synonym: "peripheral B lymphocyte tolerance induction" EXACT []
synonym: "peripheral B-cell tolerance induction" EXACT []
synonym: "peripheral B-lymphocyte tolerance induction" EXACT []
is_a: GO:0002465 ! peripheral tolerance induction
is_a: GO:0002514 ! B cell tolerance induction
is_a: GO:0019724 ! B cell mediated immunity

[Term]
id: GO:0002452
name: B cell receptor editing
namespace: biological_process
def: "The process of replacing receptors on B cells, in which RAG gene expression allows continued light-chain gene rearrangement and expression of a new light change which combines with the previous heavy chain to form a new receptor." [GOC:jal, ISBN:0781735149]
synonym: "B lymphocyte receptor editing" EXACT []
synonym: "B-cell receptor editing" EXACT []
synonym: "B-lymphocyte receptor editing" EXACT []
is_a: GO:0016447 ! somatic recombination of immunoglobulin gene segments

[Term]
id: GO:0002453
name: peripheral B cell anergy
namespace: biological_process
def: "Any process contributing to anergy, a state of functional inactivation that occurs as part of tolerance induction, in peripheral B cells." [GOC:jal, ISBN:0781735149]
synonym: "peripheral B lymphocyte anergy" EXACT []
synonym: "peripheral B-cell anergy" EXACT []
synonym: "peripheral B-lymphocyte anergy" EXACT []
is_a: GO:0002515 ! B cell anergy
relationship: part_of GO:0002451 ! peripheral B cell tolerance induction

[Term]
id: GO:0002454
name: peripheral B cell deletion
namespace: biological_process
def: "The deletion of B cells by apoptotic process occurring as part of peripheral tolerance induction and B cell selection." [GOC:add, GOC:jal, GOC:mtg_apoptosis, ISBN:0781735149]
synonym: "peripheral B lymphocyte deletion" EXACT []
synonym: "peripheral B-cell deletion" EXACT []
synonym: "peripheral B-lymphocyte deletion" EXACT []
is_a: GO:0002516 ! B cell deletion
relationship: part_of GO:0002451 ! peripheral B cell tolerance induction

[Term]
id: GO:0002455
name: humoral immune response mediated by circulating immunoglobulin
namespace: biological_process
def: "An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
synonym: "circulating antibody mediated immune response" EXACT []
synonym: "circulating immunoglobulin mediated immune response" EXACT []
synonym: "humoral defence mechanism" RELATED []
synonym: "humoral immune response mediated by circulating antibody" EXACT []
is_a: GO:0006959 ! humoral immune response
is_a: GO:0016064 ! immunoglobulin mediated immune response

[Term]
id: GO:0002456
name: T cell mediated immunity
namespace: biological_process
def: "Any process involved in the carrying out of an immune response by a T cell." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
synonym: "cell-mediated immunity" BROAD []
synonym: "cellular immune response" BROAD []
synonym: "T lymphocyte mediated immunity" EXACT []
synonym: "T-cell mediated immunity" EXACT []
synonym: "T-lymphocyte mediated immunity" EXACT []
is_a: GO:0002449 ! lymphocyte mediated immunity
is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

[Term]
id: GO:0002457
name: T cell antigen processing and presentation
namespace: biological_process
def: "The process in which a T cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, PMID:11417857, PMID:15120183]
synonym: "T lymphocyte antigen processing and presentation" EXACT []
synonym: "T-cell antigen processing and presentation" EXACT []
synonym: "T-lymphocyte antigen processing and presentation" EXACT []
is_a: GO:0019882 ! antigen processing and presentation
relationship: part_of GO:0002456 ! T cell mediated immunity

[Term]
id: GO:0002458
name: peripheral T cell tolerance induction
namespace: biological_process
def: "Tolerance induction of T cells in the periphery, in this case, any location in the body other than the thymus." [GOC:jal, ISBN:0781735149]
synonym: "peripheral T lymphocyte tolerance induction" EXACT []
synonym: "peripheral T-cell tolerance induction" EXACT []
synonym: "peripheral T-lymphocyte tolerance induction" EXACT []
is_a: GO:0002456 ! T cell mediated immunity
is_a: GO:0002465 ! peripheral tolerance induction
is_a: GO:0002517 ! T cell tolerance induction

[Term]
id: GO:0002459
name: adaptive immune response based on somatic recombination of immune receptors built from leucine-rich repeat domains
namespace: biological_process
def: "An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of variable lymphocyte receptors (VLR) incorporating leucine-rich repeat (LRR) domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Examples of this process are found in jawless fish, including the lampreys (Petromyzontidae) and hagfishes (Myxinidae)." [GOC:add, GOC:mtg_sensu, PMID:16373579]
synonym: "adaptive immune response based on somatic recombination of variable lymphocyte receptors built from leucine-rich repeat domains" EXACT []
synonym: "adaptive immune response based on somatic recombination of VLR built from LRR domains" EXACT []
synonym: "adaptive immune response in jawless fish" EXACT []
is_a: GO:0002250 ! adaptive immune response

[Term]
id: GO:0002460
name: adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
namespace: biological_process
def: "An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies). An example of this is the adaptive immune response found in Mus musculus." [GOC:add, GOC:mtg_sensu, ISBN:0781735149]
is_a: GO:0002250 ! adaptive immune response

[Term]
id: GO:0002461
name: tolerance induction dependent upon immune response
namespace: biological_process
def: "Tolerance induction dependent upon an immune response, typically a response by a mature T or B cell in the periphery resulting tolerance towards an antigen via induction of anergy, cellular deletion, or regulatory T cell activation." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
synonym: "immune response-dependent tolerance induction" EXACT []
is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
is_a: GO:0002507 ! tolerance induction

[Term]
id: GO:0002462
name: tolerance induction to nonself antigen
namespace: biological_process
def: "Tolerance induction in response to nonself antigens." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002461 ! tolerance induction dependent upon immune response

[Term]
id: GO:0002463
name: central tolerance induction to nonself antigen
namespace: biological_process
def: "Tolerance induction to nonself antigens in the central lymphoid organs." [GOC:jal, PMID:12547504]
is_a: GO:0002462 ! tolerance induction to nonself antigen
is_a: GO:0002508 ! central tolerance induction

[Term]
id: GO:0002464
name: peripheral tolerance induction to nonself antigen
namespace: biological_process
def: "Tolerance induction to nonself antigens in the periphery." [GOC:jal, ISBN:0781735149]
is_a: GO:0002462 ! tolerance induction to nonself antigen
is_a: GO:0002465 ! peripheral tolerance induction

[Term]
id: GO:0002465
name: peripheral tolerance induction
namespace: biological_process
def: "Tolerance induction in the peripheral lymphoid tissues: blood, lymph nodes, spleen, and mucosal-associated lymphoid tissues." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002461 ! tolerance induction dependent upon immune response

[Term]
id: GO:0002466
name: peripheral tolerance induction to self antigen
namespace: biological_process
def: "Tolerance induction to self antigens in the peripheral lymphoid tissues: blood, lymph nodes, spleen, and mucosal-associated lymphoid tissues." [GOC:jal, ISBN:0781735149]
is_a: GO:0002465 ! peripheral tolerance induction
is_a: GO:0002513 ! tolerance induction to self antigen

[Term]
id: GO:0002467
name: germinal center formation
namespace: biological_process
def: "The process in which germinal centers form. A germinal center is a specialized microenvironment formed when activated B cells enter lymphoid follicles. Germinal centers are the foci for B cell proliferation and somatic hypermutation." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:081533642X]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis

[Term]
id: GO:0002468
name: dendritic cell antigen processing and presentation
namespace: biological_process
def: "The process in which a dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591]
is_a: GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002469
name: myeloid dendritic cell antigen processing and presentation
namespace: biological_process
def: "The process in which a myeloid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591]
is_a: GO:0002468 ! dendritic cell antigen processing and presentation

[Term]
id: GO:0002470
name: plasmacytoid dendritic cell antigen processing and presentation
namespace: biological_process
def: "The process in which a plasmacytoid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591]
is_a: GO:0002468 ! dendritic cell antigen processing and presentation

[Term]
id: GO:0002471
name: monocyte antigen processing and presentation
namespace: biological_process
def: "The process in which a monocyte expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, PMID:11200054]
is_a: GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002472
name: macrophage antigen processing and presentation
namespace: biological_process
def: "The process in which a macrophage expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591]
is_a: GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002473
name: non-professional antigen presenting cell antigen processing and presentation
namespace: biological_process
def: "The process in which a non-professional antigen presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. Non-professional antigen presenting cells include all cell types but dendritic cells, B cells, T cells, monocytes, macrophages, and neutrophils." [GOC:add, ISBN:0781735149, PMID:15771591]
is_a: GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002474
name: antigen processing and presentation of peptide antigen via MHC class I
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class I protein complex. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:15224092, PMID:15771591]
synonym: "peptide antigen processing and presentation via MHC class I" EXACT []
xref: Reactome:REACT_110097 "Class I MHC mediated antigen processing & presentation, Sus scrofa"
xref: Reactome:REACT_114442 "Class I MHC mediated antigen processing & presentation, Xenopus tropicalis"
xref: Reactome:REACT_75820 "Class I MHC mediated antigen processing & presentation, Homo sapiens"
xref: Reactome:REACT_77569 "Class I MHC mediated antigen processing & presentation, Rattus norvegicus"
xref: Reactome:REACT_83138 "Class I MHC mediated antigen processing & presentation, Bos taurus"
xref: Reactome:REACT_84092 "Class I MHC mediated antigen processing & presentation, Taeniopygia guttata"
xref: Reactome:REACT_86224 "Class I MHC mediated antigen processing & presentation, Mus musculus"
xref: Reactome:REACT_88020 "Class I MHC mediated antigen processing & presentation, Danio rerio"
xref: Reactome:REACT_90151 "Class I MHC mediated antigen processing & presentation, Canis familiaris"
xref: Reactome:REACT_94042 "Class I MHC mediated antigen processing & presentation, Gallus gallus"
is_a: GO:0048002 ! antigen processing and presentation of peptide antigen

[Term]
id: GO:0002475
name: antigen processing and presentation via MHC class Ib
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families." [GOC:add, PMID:15928678, PMID:15928680]
is_a: GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002476
name: antigen processing and presentation of endogenous peptide antigen via MHC class Ib
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678]
synonym: "endogenous peptide antigen processing and presentation via MHC class Ib" EXACT []
is_a: GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib
is_a: GO:0002483 ! antigen processing and presentation of endogenous peptide antigen

[Term]
id: GO:0002477
name: antigen processing and presentation of exogenous peptide antigen via MHC class Ib
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678]
synonym: "exogenous peptide antigen processing and presentation via MHC class Ib" EXACT []
is_a: GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib
is_a: GO:0002478 ! antigen processing and presentation of exogenous peptide antigen

[Term]
id: GO:0002478
name: antigen processing and presentation of exogenous peptide antigen
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell." [GOC:add, ISBN:0781735149]
synonym: "exogenous peptide antigen processing and presentation" EXACT []
is_a: GO:0019884 ! antigen processing and presentation of exogenous antigen
is_a: GO:0048002 ! antigen processing and presentation of peptide antigen

[Term]
id: GO:0002479
name: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class I molecule. Class I here refers to classical class I molecules." [GOC:add, PMID:15224093, PMID:15771591, PMID:16181335]
synonym: "cross presentation" BROAD []
synonym: "cross-presentation" BROAD []
synonym: "exogenous peptide antigen processing and presentation via MHC class I, TAP-dependent" EXACT []
synonym: "TAP-dependent antigen processing and presentation of exogenous peptide antigen via MHC class I" EXACT []
synonym: "TAP-dependent exogenous peptide antigen processing and presentation via MHC class I" EXACT []
xref: Reactome:REACT_111056 "Cross-presentation of soluble exogenous antigens (endosomes), Homo sapiens"
xref: Reactome:REACT_111174 "Cross-presentation of particulate exogenous antigens (phagosomes), Homo sapiens"
xref: Reactome:REACT_111178 "ER-Phagosome pathway, Homo sapiens"
is_a: GO:0042590 ! antigen processing and presentation of exogenous peptide antigen via MHC class I

[Term]
id: GO:0002480
name: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class I here refers to classical class I molecules." [GOC:add, PMID:15224093, PMID:15771591, PMID:16181335]
synonym: "cross presentation" BROAD []
synonym: "cross-presentation" BROAD []
synonym: "exogenous peptide antigen processing and presentation via MHC class I, TAP-independent" EXACT []
synonym: "TAP-independent antigen processing and presentation of exogenous peptide antigen via MHC class I" EXACT []
synonym: "TAP-independent exogenous peptide antigen processing and presentation via MHC class I" EXACT []
xref: Reactome:REACT_111168 "Endosomal/Vacuolar pathway, Homo sapiens"
is_a: GO:0042590 ! antigen processing and presentation of exogenous peptide antigen via MHC class I

[Term]
id: GO:0002481
name: antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678]
synonym: "exogenous peptide antigen processing and presentation via MHC class Ib, TAP-dependent" EXACT []
synonym: "TAP-dependent antigen processing and presentation of exogenous peptide antigen via MHC class Ib" EXACT []
synonym: "TAP-dependent exogenous peptide antigen processing and presentation via MHC class Ib" EXACT []
is_a: GO:0002477 ! antigen processing and presentation of exogenous peptide antigen via MHC class Ib

[Term]
id: GO:0002482
name: antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-independent
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678]
synonym: "exogenous peptide antigen processing and presentation via MHC class Ib, TAP-independent" EXACT []
synonym: "TAP-independent antigen processing and presentation of exogenous peptide antigen via MHC class Ib" EXACT []
synonym: "TAP-independent exogenous peptide antigen processing and presentation via MHC class Ib" EXACT []
is_a: GO:0002477 ! antigen processing and presentation of exogenous peptide antigen via MHC class Ib

[Term]
id: GO:0002483
name: antigen processing and presentation of endogenous peptide antigen
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell." [GOC:add, ISBN:0781735149]
synonym: "endogenous peptide antigen processing and presentation" EXACT []
is_a: GO:0019883 ! antigen processing and presentation of endogenous antigen
is_a: GO:0048002 ! antigen processing and presentation of peptide antigen

[Term]
id: GO:0002484
name: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via an ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:14647477, PMID:15771591]
synonym: "endogenous peptide antigen processing and presentation via MHC class I via ER pathway" EXACT []
is_a: GO:0019885 ! antigen processing and presentation of endogenous peptide antigen via MHC class I

[Term]
id: GO:0002485
name: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP-dependent ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER following TAP-dependent transport from the cytosol. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:14647477, PMID:15771591]
synonym: "endogenous peptide antigen processing and presentation via MHC class I via ER pathway, TAP-dependent" EXACT []
synonym: "TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway" EXACT []
synonym: "TAP-dependent endogenous peptide antigen processing and presentation via MHC class I via ER pathway" EXACT []
is_a: GO:0002484 ! antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway

[Term]
id: GO:0002486
name: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP-independent ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER following transport from the cytosol via a TAP-independent pathway. Class I here refers to classical class I molecules." [GOC:add, PMID:14647477, PMID:15771591]
synonym: "endogenous peptide antigen processing and presentation via MHC class I via ER pathway, TAP-independent" EXACT []
synonym: "TAP-independent antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway" EXACT []
synonym: "TAP-independent endogenous peptide antigen processing and presentation via MHC class I via ER pathway" EXACT []
is_a: GO:0002484 ! antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway

[Term]
id: GO:0002487
name: antigen processing and presentation of endogenous peptide antigen via MHC class I via endolysosomal pathway
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in an endolysosome. Class I here refers to classical class I molecules." [GOC:add, PMID:10631943]
synonym: "endogenous peptide antigen processing and presentation via MHC class I via endolysosomal pathway" EXACT []
is_a: GO:0019885 ! antigen processing and presentation of endogenous peptide antigen via MHC class I

[Term]
id: GO:0002488
name: antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via an ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class Ib molecule in the ER. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678]
synonym: "endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway" EXACT []
is_a: GO:0002476 ! antigen processing and presentation of endogenous peptide antigen via MHC class Ib

[Term]
id: GO:0002489
name: antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678]
synonym: "endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway, TAP-dependent" EXACT []
synonym: "TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway" EXACT []
synonym: "TAP-dependent endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway" EXACT []
is_a: GO:0002488 ! antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway

[Term]
id: GO:0002490
name: antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-independent
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678]
synonym: "endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway, TAP-independent" EXACT []
synonym: "TAP-independent antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway" EXACT []
synonym: "TAP-independent endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway" EXACT []
is_a: GO:0002488 ! antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway

[Term]
id: GO:0002491
name: antigen processing and presentation of endogenous peptide antigen via MHC class II
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein." [GOC:add, PMID:15531770, PMID:16181338]
synonym: "endogenous peptide antigen processing and presentation via MHC class II" EXACT []
is_a: GO:0002483 ! antigen processing and presentation of endogenous peptide antigen
is_a: GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II

[Term]
id: GO:0002492
name: peptide antigen assembly with MHC class Ib protein complex
namespace: biological_process
def: "The binding of a peptide antigen to the antigen binding groove of an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678]
is_a: GO:0002501 ! peptide antigen assembly with MHC protein complex
relationship: part_of GO:0002398 ! MHC class Ib protein complex assembly
relationship: part_of GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib

[Term]
id: GO:0002493
name: lipid antigen assembly with MHC class Ib protein complex
namespace: biological_process
def: "The binding of a lipid antigen to the antigen binding groove of an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the CD1 gene family." [GOC:add, PMID:15928678, PMID:15928680]
is_a: GO:0065005 ! protein-lipid complex assembly
relationship: part_of GO:0002398 ! MHC class Ib protein complex assembly
relationship: part_of GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib

[Term]
id: GO:0002494
name: lipid antigen transport
namespace: biological_process
def: "The directed movement of a lipid antigen into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:add, PMID:15928678, PMID:15928680]
is_a: GO:0006869 ! lipid transport
relationship: part_of GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib

[Term]
id: GO:0002495
name: antigen processing and presentation of peptide antigen via MHC class II
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein." [GOC:add, ISBN:0781735149, PMID:15531770, PMID:15771591]
synonym: "peptide antigen processing and presentation via MHC class II" EXACT []
is_a: GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
is_a: GO:0048002 ! antigen processing and presentation of peptide antigen

[Term]
id: GO:0002496
name: proteolysis associated with antigen processing and presentation
namespace: biological_process
def: "The hydrolysis of a peptide bond or bonds within a protein contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149, PMID:15224092, PMID:15771591]
is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process
intersection_of: GO:0006508 ! proteolysis
intersection_of: part_of GO:0048002 ! antigen processing and presentation of peptide antigen
relationship: part_of GO:0048002 ! antigen processing and presentation of peptide antigen

[Term]
id: GO:0002497
name: proteasomal proteolysis associated with antigen processing and presentation
namespace: biological_process
def: "The hydrolysis of a peptide bond or bonds within a protein by the proteasome complex contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149, PMID:15224092, PMID:15771591]
is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation

[Term]
id: GO:0002498
name: proteolysis within endoplasmic reticulum associated with antigen processing and presentation
namespace: biological_process
def: "The hydrolysis of a peptide bond or bonds within a protein by ER resident proteases contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149, PMID:15224092, PMID:15771591]
synonym: "endoplasmic reticulum proteolysis associated with antigen processing and presentation" EXACT []
synonym: "ER proteolysis associated with antigen processing and presentation" EXACT []
synonym: "proteolysis within ER associated with antigen processing and presentation" EXACT []
is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation

[Term]
id: GO:0002499
name: proteolysis within endosome associated with antigen processing and presentation
namespace: biological_process
def: "The hydrolysis of a peptide bond or bonds within a protein by endosomal resident proteases contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149, PMID:15771591]
synonym: "endosomal proteolysis associated with antigen processing and presentation" EXACT []
is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation
intersection_of: GO:0002496 ! proteolysis associated with antigen processing and presentation
intersection_of: occurs_in GO:0005768 ! endosome
relationship: occurs_in GO:0005768 ! endosome

[Term]
id: GO:0002500
name: proteolysis within lysosome associated with antigen processing and presentation
namespace: biological_process
def: "The hydrolysis of a peptide bond or bonds within a protein by lysosomal resident proteases contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149, PMID:15771591]
synonym: "lysosomal proteolysis associated with antigen processing and presentation" EXACT []
is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation
is_a: GO:0006624 ! vacuolar protein processing
is_a: GO:1905146 ! lysosomal protein catabolic process
intersection_of: GO:0002496 ! proteolysis associated with antigen processing and presentation
intersection_of: occurs_in GO:0005764 ! lysosome
relationship: occurs_in GO:0005764 ! lysosome

[Term]
id: GO:0002501
name: peptide antigen assembly with MHC protein complex
namespace: biological_process
def: "The binding of a peptide to the antigen binding groove of an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591]
is_a: GO:0043623 ! cellular protein complex assembly
relationship: part_of GO:0002396 ! MHC protein complex assembly
relationship: part_of GO:0048002 ! antigen processing and presentation of peptide antigen

[Term]
id: GO:0002502
name: peptide antigen assembly with MHC class I protein complex
namespace: biological_process
def: "The binding of a peptide to the antigen binding groove of an MHC class I protein complex. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:15771591]
is_a: GO:0002501 ! peptide antigen assembly with MHC protein complex
relationship: part_of GO:0002397 ! MHC class I protein complex assembly
relationship: part_of GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I

[Term]
id: GO:0002503
name: peptide antigen assembly with MHC class II protein complex
namespace: biological_process
def: "The binding of a peptide to the antigen binding groove of an MHC class II protein complex." [GOC:add, ISBN:0781735149, PMID:15771591]
is_a: GO:0002501 ! peptide antigen assembly with MHC protein complex
relationship: part_of GO:0002399 ! MHC class II protein complex assembly
relationship: part_of GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II

[Term]
id: GO:0002504
name: antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses antigen (peptide or polysaccharide) on its cell surface in association with an MHC class II protein complex." [GOC:add, ISBN:0781735149, PMID:15531770, PMID:15771591, PMID:16153240]
synonym: "peptide or polysaccharide antigen processing and presentation of via MHC class II" EXACT []
is_a: GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002505
name: antigen processing and presentation of polysaccharide antigen via MHC class II
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a polysaccharide antigen on its cell surface in association with an MHC class II protein complex." [GOC:add, PMID:16153240]
synonym: "polysaccharide antigen processing and presentation via MHC class II" EXACT []
is_a: GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

[Term]
id: GO:0002506
name: polysaccharide assembly with MHC class II protein complex
namespace: biological_process
def: "The binding of a polysaccharide to the antigen binding groove of an MHC class II protein complex." [GOC:add, PMID:16153240]
is_a: GO:0065006 ! protein-carbohydrate complex assembly
relationship: part_of GO:0002399 ! MHC class II protein complex assembly
relationship: part_of GO:0002505 ! antigen processing and presentation of polysaccharide antigen via MHC class II

[Term]
id: GO:0002507
name: tolerance induction
namespace: biological_process
def: "A process that directly activates any of the steps required for tolerance, a physiologic state in which the immune system does not react destructively against the components of an organism that harbors it or against antigens that are introduced to it." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002376 ! immune system process
relationship: part_of GO:0002520 ! immune system development

[Term]
id: GO:0002508
name: central tolerance induction
namespace: biological_process
def: "Tolerance induction in the central lymphoid organs: the thymus and bone marrow." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002507 ! tolerance induction

[Term]
id: GO:0002509
name: central tolerance induction to self antigen
namespace: biological_process
def: "Tolerance induction in the central lymphoid organs directed at self antigens." [GOC:jal, ISBN:0781735149, PMID:16460922]
is_a: GO:0002508 ! central tolerance induction
is_a: GO:0002513 ! tolerance induction to self antigen

[Term]
id: GO:0002510
name: central B cell tolerance induction
namespace: biological_process
def: "Tolerance induction of B cells in the bone marrow." [GOC:jal, PMID:16460922]
synonym: "central B lymphocyte tolerance induction" EXACT []
synonym: "central B-cell tolerance induction" EXACT []
synonym: "central B-lymphocyte tolerance induction" EXACT []
is_a: GO:0002508 ! central tolerance induction
is_a: GO:0002514 ! B cell tolerance induction

[Term]
id: GO:0002511
name: central B cell receptor editing
namespace: biological_process
def: "Receptor editing occurring in B cells in the bone marrow." [GOC:jal, PMID:16460922]
synonym: "central B lymphocyte receptor editing" EXACT []
synonym: "central B-cell receptor editing" EXACT []
synonym: "central B-lymphocyte receptor editing" EXACT []
is_a: GO:0002452 ! B cell receptor editing

[Term]
id: GO:0002512
name: central T cell tolerance induction
namespace: biological_process
def: "Tolerance induction of T cells in the thymus." [GOC:jal, ISBN:0781735149]
synonym: "central T lymphocyte tolerance induction" EXACT []
synonym: "central T-cell tolerance induction" EXACT []
synonym: "central T-lymphocyte tolerance induction" EXACT []
is_a: GO:0002508 ! central tolerance induction
is_a: GO:0002517 ! T cell tolerance induction

[Term]
id: GO:0002513
name: tolerance induction to self antigen
namespace: biological_process
def: "Tolerance induction directed at self antigens." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002507 ! tolerance induction

[Term]
id: GO:0002514
name: B cell tolerance induction
namespace: biological_process
def: "A process involving any mechanism for tolerance induction in B cells." [GOC:jal, ISBN:0781735149, PMID:16460922]
synonym: "B lymphocyte tolerance induction" EXACT []
synonym: "B-cell tolerance induction" EXACT []
synonym: "B-lymphocyte tolerance induction" EXACT []
is_a: GO:0002507 ! tolerance induction

[Term]
id: GO:0002515
name: B cell anergy
namespace: biological_process
def: "Any process contributing to anergy in B cells, a state of functional inactivation which is part of B cell tolerance induction." [GOC:jal, ISBN:0781735149]
synonym: "B lymphocyte anergy" EXACT []
synonym: "B-cell anergy" EXACT []
synonym: "B-lymphocyte anergy" EXACT []
is_a: GO:0002249 ! lymphocyte anergy
is_a: GO:0002514 ! B cell tolerance induction

[Term]
id: GO:0002516
name: B cell deletion
namespace: biological_process
def: "The apoptotic death of B cells which is part of B cell tolerance induction." [GOC:add, GOC:jal, ISBN:0781735149]
synonym: "B lymphocyte deletion" EXACT []
synonym: "B-cell deletion" EXACT []
synonym: "B-lymphocyte deletion" EXACT []
is_a: GO:0001783 ! B cell apoptotic process
is_a: GO:1902742 ! apoptotic process involved in development
intersection_of: GO:0001783 ! B cell apoptotic process
intersection_of: part_of GO:0002514 ! B cell tolerance induction
relationship: part_of GO:0002514 ! B cell tolerance induction

[Term]
id: GO:0002517
name: T cell tolerance induction
namespace: biological_process
def: "A process involving any mechanism for tolerance induction in T cells." [GOC:jal, ISBN:0781735149, PMID:16551263]
synonym: "T lymphocyte tolerance induction" EXACT []
synonym: "T-cell tolerance induction" EXACT []
synonym: "T-lymphocyte tolerance induction" EXACT []
is_a: GO:0002507 ! tolerance induction

[Term]
id: GO:0002518
name: lymphocyte chemotaxis across high endothelial venule
namespace: biological_process
def: "The movement of a lymphocyte to cross a high endothelial venule in response to an external stimulus." [GOC:add, ISBN:0781735149, PMID:15122201]
is_a: GO:0048247 ! lymphocyte chemotaxis

[Term]
id: GO:0002519
name: natural killer cell tolerance induction
namespace: biological_process
def: "Tolerance induction of natural killer cells." [GOC:jal, PMID:16546094]
synonym: "NK cell tolerance induction" EXACT []
is_a: GO:0002507 ! tolerance induction

[Term]
id: GO:0002520
name: immune system development
namespace: biological_process
def: "The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:add, GOC:dph]
is_a: GO:0002376 ! immune system process
is_a: GO:0048731 ! system development

[Term]
id: GO:0002521
name: leukocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." [CL:0000738, GOC:add, PMID:16551264]
synonym: "immune cell differentiation" EXACT []
synonym: "leucocyte differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0030097 ! hemopoiesis

[Term]
id: GO:0002522
name: leukocyte migration involved in immune response
namespace: biological_process
def: "The movement of a leukocyte within or between different tissues and organs of the body as part of an immune response." [GOC:add, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538]
synonym: "immune cell migration during immune response" EXACT []
synonym: "immune cell trafficking during immune response" EXACT []
synonym: "leucocyte migration during immune response" EXACT []
synonym: "leucocyte trafficking during immune response" EXACT []
synonym: "leukocyte trafficking during immune response" EXACT []
is_a: GO:0002252 ! immune effector process
is_a: GO:0050900 ! leukocyte migration
intersection_of: GO:0050900 ! leukocyte migration
intersection_of: part_of GO:0006955 ! immune response
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0002523
name: leukocyte migration involved in inflammatory response
namespace: biological_process
def: "The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response." [GOC:add, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538]
synonym: "immune cell migration during inflammatory response" RELATED []
synonym: "immune cell trafficking during inflammatory response" RELATED []
synonym: "leucocyte migration during inflammatory response" RELATED []
synonym: "leucocyte trafficking during inflammatory response" RELATED []
synonym: "leukocyte migration during inflammatory response" RELATED [GOC:dph]
synonym: "leukocyte trafficking during inflammatory response" RELATED []
is_a: GO:0050900 ! leukocyte migration
intersection_of: GO:0050900 ! leukocyte migration
intersection_of: part_of GO:0006954 ! inflammatory response
relationship: part_of GO:0006954 ! inflammatory response

[Term]
id: GO:0002524
name: hypersensitivity
namespace: biological_process
def: "An inflammatory response to an exogenous environmental antigen or an endogenous antigen initiated by the adaptive immune system." [GOC:jal, ISBN:0781735149]
synonym: "hypersensitivity response" RELATED [ISBN:0781735149]
xref: Wikipedia:Hypersensitivity
is_a: GO:0002438 ! acute inflammatory response to antigenic stimulus

[Term]
id: GO:0002525
name: acute inflammatory response to non-antigenic stimulus
namespace: biological_process
def: "An acute inflammatory response to non-antigenic stimuli such as heat or physical trauma." [GOC:jal, PMID:16459497, PMID:9073326]
is_a: GO:0002526 ! acute inflammatory response

[Term]
id: GO:0002526
name: acute inflammatory response
namespace: biological_process
def: "Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
is_a: GO:0006954 ! inflammatory response

[Term]
id: GO:0002527
name: vasodilation involved in acute inflammatory response
namespace: biological_process
def: "An increase in the internal diameter of blood vessels, especially arterioles or capillaries, usually resulting in a decrease in blood pressure contributing to an acute inflammatory response." [GOC:jal]
synonym: "vasodilation during acute inflammatory response" RELATED [GOC:dph]
is_a: GO:0042311 ! vasodilation
intersection_of: GO:0042311 ! vasodilation
intersection_of: part_of GO:0002526 ! acute inflammatory response
relationship: part_of GO:0002526 ! acute inflammatory response

[Term]
id: GO:0002528
name: regulation of vascular permeability involved in acute inflammatory response
namespace: biological_process
def: "Any process that modulates the extent to which blood vessels can be pervaded by fluid contributing to an acute inflammatory response." [GOC:jal]
synonym: "regulation of vascular permeability during acute inflammatory response" RELATED [GOC:dph]
is_a: GO:0043114 ! regulation of vascular permeability
intersection_of: GO:0043114 ! regulation of vascular permeability
intersection_of: part_of GO:0002526 ! acute inflammatory response
relationship: part_of GO:0002526 ! acute inflammatory response

[Term]
id: GO:0002529
name: regulation of plasma kallikrein-kinin cascade
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the plasma kallikrein-kinin cascade." [GOC:add]
is_a: GO:0002256 ! regulation of kinin cascade
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002353 ! plasma kallikrein-kinin cascade
relationship: regulates GO:0002353 ! plasma kallikrein-kinin cascade

[Term]
id: GO:0002530
name: regulation of systemic arterial blood pressure involved in acute-phase response
namespace: biological_process
def: "Any process that modulates the force with which blood travels through the circulatory system that contributes to the acute phase response. The acute phase response occurs during the early phases of an infection and is marked by changes in the production of plasma proteins such as C-reactive protein." [GOC:jal, ISBN:081533642X]
synonym: "blood pressure regulation during acute phase response" RELATED []
synonym: "regulation of systemic arterial blood pressure during acute phase response" RELATED [GOC:tb]
is_a: GO:0003073 ! regulation of systemic arterial blood pressure
intersection_of: GO:0003073 ! regulation of systemic arterial blood pressure
intersection_of: part_of GO:0006953 ! acute-phase response
relationship: part_of GO:0006953 ! acute-phase response

[Term]
id: GO:0002531
name: regulation of heart contraction involved in acute-phase response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of heart contraction that contributes to the acute phase response. The acute phase response occurs during the early phases of an infection and is marked by changes in the production of plasma proteins such as C-reactive protein." [GOC:jal, PMID:15642986, PMID:15834430]
synonym: "regulation of cardiac contraction during acute phase response" RELATED []
synonym: "regulation of heart contraction during acute phase response" RELATED [GOC:tb]
is_a: GO:0008016 ! regulation of heart contraction
intersection_of: GO:0008016 ! regulation of heart contraction
intersection_of: part_of GO:0006953 ! acute-phase response
relationship: part_of GO:0006953 ! acute-phase response

[Term]
id: GO:0002532
name: production of molecular mediator involved in inflammatory response
namespace: biological_process
def: "The synthesis or release of any molecular mediator of the inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:dph, GOC:tb, ISBN:0781735149]
synonym: "production of cellular mediator of acute inflammation" RELATED []
synonym: "production of molecular mediator involved in acute inflammatory response" BROAD []
is_a: GO:0044707 ! single-multicellular organism process
relationship: part_of GO:0006954 ! inflammatory response

[Term]
id: GO:0002533
name: lysosomal enzyme secretion involved in inflammatory response
namespace: biological_process
def: "The regulated release of lysosomal enzymes by a cell as part of an inflammatory response." [GOC:jal, PMID:11836514]
synonym: "lysosomal enzyme secretion involved in acute inflammatory response" RELATED [GOC:mah]
synonym: "secretion of lysosomal enzymes involved in acute inflammatory response" BROAD []
synonym: "secretion of lysosomal enzymes involved in inflammatory response" EXACT [GOC:curators]
is_a: GO:0033299 ! secretion of lysosomal enzymes
intersection_of: GO:0033299 ! secretion of lysosomal enzymes
intersection_of: part_of GO:0006954 ! inflammatory response
relationship: part_of GO:0002393 ! lysosomal enzyme production involved in inflammatory response
relationship: part_of GO:0006954 ! inflammatory response

[Term]
id: GO:0002534
name: cytokine production involved in inflammatory response
namespace: biological_process
def: "The synthesis or release of a cytokine following a inflammatory stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149]
synonym: "cytokine production involved in acute inflammatory response" BROAD []
is_a: GO:0001816 ! cytokine production
is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response
intersection_of: GO:0001816 ! cytokine production
intersection_of: part_of GO:0006954 ! inflammatory response
relationship: part_of GO:0006954 ! inflammatory response

[Term]
id: GO:0002535
name: platelet activating factor secretion involved in inflammatory response
namespace: biological_process
def: "The regulated release of platelet activating factor by a cell as part of an inflammatory response." [GOC:add, ISBN:0781735149]
synonym: "platelet activating factor secretion involved in acute inflammatory response" BROAD []
is_a: GO:0002392 ! platelet activating factor secretion
intersection_of: GO:0002392 ! platelet activating factor secretion
intersection_of: part_of GO:0006954 ! inflammatory response
relationship: part_of GO:0002391 ! platelet activating factor production involved in inflammatory response
relationship: part_of GO:0006954 ! inflammatory response

[Term]
id: GO:0002536
name: respiratory burst involved in inflammatory response
namespace: biological_process
def: "A phase of elevated metabolic activity, during which oxygen consumption increases following a stimulus as part of an inflammatory response; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, resulting in an increase in their intracellular or extracellular levels." [GOC:add, ISBN:0781735149]
synonym: "oxidative burst during acute inflammatory response" BROAD []
synonym: "production of reactive oxygen species during acute inflammatory response" BROAD []
synonym: "respiratory burst involved in acute inflammatory response" BROAD []
is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response
is_a: GO:0002679 ! respiratory burst involved in defense response
intersection_of: GO:0045730 ! respiratory burst
intersection_of: part_of GO:0006954 ! inflammatory response
relationship: part_of GO:0006954 ! inflammatory response

[Term]
id: GO:0002537
name: nitric oxide production involved in inflammatory response
namespace: biological_process
def: "The synthesis or release of nitric oxide following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149]
synonym: "nitric oxide production involved in acute inflammatory response" BROAD [GOC:mah]
synonym: "production of nitric oxide involved in acute inflammatory response" BROAD []
synonym: "production of nitric oxide involved in inflammatory response" EXACT [GOC:curators]
is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response

[Term]
id: GO:0002538
name: arachidonic acid metabolite production involved in inflammatory response
namespace: biological_process
def: "The synthesis or release of products of arachidonic acid metabolism following a stimulus as part of an inflammatory response, resulting in an increase in their intracellular or extracellular levels." [GOC:add, ISBN:0781735149]
synonym: "arachidonic acid metabolite production involved in acute inflammatory response" BROAD [GOC:mah]
synonym: "production of arachidonic acid metabolites involved in acute inflammatory response" BROAD []
synonym: "production of arachidonic acid metabolites involved in inflammatory response" EXACT [GOC:curators]
is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response

[Term]
id: GO:0002539
name: prostaglandin production involved in inflammatory response
namespace: biological_process
def: "The synthesis or release of any prostaglandin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149]
synonym: "prostaglandin production involved in acute inflammatory response" BROAD []
is_a: GO:0002538 ! arachidonic acid metabolite production involved in inflammatory response

[Term]
id: GO:0002540
name: leukotriene production involved in inflammatory response
namespace: biological_process
def: "The synthesis or release of any leukotriene following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149]
synonym: "leukotriene production involved in acute inflammatory response" BROAD []
is_a: GO:0002538 ! arachidonic acid metabolite production involved in inflammatory response

[Term]
id: GO:0002541
name: activation of plasma proteins involved in acute inflammatory response
namespace: biological_process
def: "Any process activating plasma proteins by proteolysis as part of an acute inflammatory response." [GOC:jal, ISBN:0781735149]
is_a: GO:0016485 ! protein processing
relationship: part_of GO:0002526 ! acute inflammatory response

[Term]
id: GO:0002542
name: Factor XII activation
namespace: biological_process
def: "Any process that activates Factor XII (Hageman factor). Factor XII is a protein synthesized by the liver that circulates in an inactive form until it encounters collagen or basement membrane or activated platelets (as occurs at the site of endothelial injury). Factor XII then undergoes a conformational change (becoming factor XIIa), exposing an active serine center that can subsequently cleave protein substrates and activate a variety of mediator systems. Factor XII is a participant in the clotting cascade as well as the kinin cascade." [GOC:jal, ISBN:0721601871]
synonym: "Hageman factor activation" EXACT []
is_a: GO:0002675 ! positive regulation of acute inflammatory response
is_a: GO:0010954 ! positive regulation of protein processing
relationship: part_of GO:0002353 ! plasma kallikrein-kinin cascade
relationship: positively_regulates GO:0002541 ! activation of plasma proteins involved in acute inflammatory response

[Term]
id: GO:0002543
name: activation of blood coagulation via clotting cascade
namespace: biological_process
def: "Any process that initiates the clotting cascade of blood coagulation, a cascade of plasma enzymes that is triggered following damage to blood vessels, leading to formation of a clot." [GOC:jal, ISBN:0781735149]
synonym: "activation of clotting cascade" EXACT []
is_a: GO:0030194 ! positive regulation of blood coagulation
relationship: part_of GO:0002526 ! acute inflammatory response

[Term]
id: GO:0002544
name: chronic inflammatory response
namespace: biological_process
def: "Inflammation of prolonged duration (weeks or months) in which active inflammation, tissue destruction, and attempts at repair are proceeding simultaneously. Although it may follow acute inflammation, chronic inflammation frequently begins insidiously, as a low-grade, smoldering, often asymptomatic response." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
is_a: GO:0006954 ! inflammatory response

[Term]
id: GO:0002545
name: chronic inflammatory response to non-antigenic stimulus
namespace: biological_process
def: "A chronic inflammatory response to a non-antigenic stimulus such as heat or physical trauma." [GOC:jal]
is_a: GO:0002544 ! chronic inflammatory response

[Term]
id: GO:0002546
name: negative regulation of tissue kallikrein-kinin cascade
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the tissue kallikrein-kinin cascade." [GOC:add]
synonym: "down regulation of tissue kallikrein-kinin cascade" EXACT []
synonym: "down-regulation of tissue kallikrein-kinin cascade" EXACT []
synonym: "downregulation of tissue kallikrein-kinin cascade" EXACT []
synonym: "inhibition of tissue kallikrein-kinin cascade" NARROW []
synonym: "negative regulation of glandular kallikrein-kinin cascade" EXACT []
is_a: GO:0002257 ! negative regulation of kinin cascade
is_a: GO:0002382 ! regulation of tissue kallikrein-kinin cascade
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002255 ! tissue kallikrein-kinin cascade
relationship: negatively_regulates GO:0002255 ! tissue kallikrein-kinin cascade

[Term]
id: GO:0002547
name: positive regulation of tissue kallikrein-kinin cascade
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of the tissue kallikrein-kinin cascade." [GOC:add]
synonym: "activation of tissue kallikrein-kinin cascade" NARROW []
synonym: "positive regulation of glandular kallikrein-kinin cascade" EXACT []
synonym: "stimulation of tissue kallikrein-kinin cascade" NARROW []
synonym: "up regulation of tissue kallikrein-kinin cascade" EXACT []
synonym: "up-regulation of tissue kallikrein-kinin cascade" EXACT []
synonym: "upregulation of tissue kallikrein-kinin cascade" EXACT []
is_a: GO:0002258 ! positive regulation of kinin cascade
is_a: GO:0002382 ! regulation of tissue kallikrein-kinin cascade
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002255 ! tissue kallikrein-kinin cascade
relationship: positively_regulates GO:0002255 ! tissue kallikrein-kinin cascade

[Term]
id: GO:0002548
name: monocyte chemotaxis
namespace: biological_process
def: "The movement of a monocyte in response to an external stimulus." [GOC:add, PMID:11696603, PMID:15173832]
is_a: GO:0030595 ! leukocyte chemotaxis
is_a: GO:0097529 ! myeloid leukocyte migration

[Term]
id: GO:0002549
name: negative regulation of plasma kallikrein-kinin cascade
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the plasma kallikrein-kinin cascade." [GOC:add]
synonym: "down regulation of plasma kallikrein-kinin cascade" EXACT []
synonym: "down-regulation of plasma kallikrein-kinin cascade" EXACT []
synonym: "downregulation of plasma kallikrein-kinin cascade" EXACT []
synonym: "inhibition of plasma kallikrein-kinin cascade" NARROW []
is_a: GO:0002257 ! negative regulation of kinin cascade
is_a: GO:0002529 ! regulation of plasma kallikrein-kinin cascade
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002353 ! plasma kallikrein-kinin cascade
relationship: negatively_regulates GO:0002353 ! plasma kallikrein-kinin cascade

[Term]
id: GO:0002550
name: positive regulation of plasma kallikrein-kinin cascade
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of the plasma kallikrein-kinin cascade." [GOC:add]
synonym: "activation of plasma kallikrein-kinin cascade" NARROW []
synonym: "stimulation of plasma kallikrein-kinin cascade" NARROW []
synonym: "up regulation of plasma kallikrein-kinin cascade" EXACT []
synonym: "up-regulation of plasma kallikrein-kinin cascade" EXACT []
synonym: "upregulation of plasma kallikrein-kinin cascade" EXACT []
is_a: GO:0002258 ! positive regulation of kinin cascade
is_a: GO:0002529 ! regulation of plasma kallikrein-kinin cascade
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002353 ! plasma kallikrein-kinin cascade
relationship: positively_regulates GO:0002353 ! plasma kallikrein-kinin cascade

[Term]
id: GO:0002551
name: mast cell chemotaxis
namespace: biological_process
def: "The movement of a mast cell in response to an external stimulus." [GOC:add, PMID:11292027, PMID:12789214, PMID:16448392]
is_a: GO:0030595 ! leukocyte chemotaxis
is_a: GO:0097531 ! mast cell migration

[Term]
id: GO:0002552
name: serotonin secretion by mast cell
namespace: biological_process
def: "The regulated release of serotonin by a mast cell or group of mast cells." [GOC:add, ISBN:0781735149]
synonym: "serotonin release by mast cell" RELATED [GOC:tb]
is_a: GO:0002442 ! serotonin secretion involved in inflammatory response
is_a: GO:1902582 ! single-organism intracellular transport
relationship: part_of GO:0043303 ! mast cell degranulation

[Term]
id: GO:0002553
name: histamine secretion by mast cell
namespace: biological_process
def: "The regulated release of histamine by a mast cell or group of mast cells." [GOC:add, ISBN:0781735149]
is_a: GO:0002441 ! histamine secretion involved in inflammatory response
is_a: GO:1902582 ! single-organism intracellular transport
relationship: part_of GO:0043303 ! mast cell degranulation

[Term]
id: GO:0002554
name: serotonin secretion by platelet
namespace: biological_process
def: "The regulated release of serotonin by a platelet or group of platelets." [GOC:add, ISBN:0781735149]
synonym: "serotonin release by platelet" RELATED [GOC:tb]
is_a: GO:0002442 ! serotonin secretion involved in inflammatory response
relationship: part_of GO:0002576 ! platelet degranulation

[Term]
id: GO:0002555
name: histamine secretion by platelet
namespace: biological_process
def: "The regulated release of histamine by a platelet or group of platelets." [GOC:add, PMID:9117517]
is_a: GO:0002441 ! histamine secretion involved in inflammatory response
relationship: part_of GO:0002576 ! platelet degranulation

[Term]
id: GO:0002556
name: serotonin secretion by basophil
namespace: biological_process
def: "The regulated release of serotonin by a basophil or group of basophils." [GOC:add, ISBN:0781735149]
synonym: "serotonin release by basophil" RELATED [GOC:tb]
is_a: GO:0002442 ! serotonin secretion involved in inflammatory response
relationship: part_of GO:0002561 ! basophil degranulation

[Term]
id: GO:0002557
name: histamine secretion by basophil
namespace: biological_process
def: "The regulated release of histamine by a basophil or group of basophils." [GOC:add, ISBN:0781735149]
is_a: GO:0002441 ! histamine secretion involved in inflammatory response
relationship: part_of GO:0002561 ! basophil degranulation

[Term]
id: GO:0002558
name: type I hypersensitivity mediated by mast cells
namespace: biological_process
def: "An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines." [GOC:add, ISBN:0781735149]
is_a: GO:0002448 ! mast cell mediated immunity
is_a: GO:0016068 ! type I hypersensitivity

[Term]
id: GO:0002559
name: type I hypersensitivity mediated by basophils
namespace: biological_process
def: "An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines." [GOC:add, ISBN:0781735149]
is_a: GO:0002560 ! basophil mediated immunity
is_a: GO:0016068 ! type I hypersensitivity

[Term]
id: GO:0002560
name: basophil mediated immunity
namespace: biological_process
def: "Any process involved in the carrying out of an immune response by a basophil." [GOC:add, ISBN:0781735149]
is_a: GO:0002444 ! myeloid leukocyte mediated immunity

[Term]
id: GO:0002561
name: basophil degranulation
namespace: biological_process
def: "The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a basophil." [GOC:add, ISBN:0781735149]
is_a: GO:0002276 ! basophil activation involved in immune response
is_a: GO:0043299 ! leukocyte degranulation
relationship: part_of GO:0002560 ! basophil mediated immunity

[Term]
id: GO:0002562
name: somatic diversification of immune receptors via germline recombination within a single locus
namespace: biological_process
def: "The process in which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus." [GOC:add, ISBN:0781735149, PMID:16102575, PMID:16166509]
is_a: GO:0002200 ! somatic diversification of immune receptors
is_a: GO:0016444 ! somatic cell DNA recombination

[Term]
id: GO:0002563
name: somatic diversification of immune receptors via alternate splicing
namespace: biological_process
def: "The process in which immune receptor genes are diversified through alternate splicing." [GOC:add, ISBN:0781735149, PMID:16166509]
is_a: GO:0002200 ! somatic diversification of immune receptors

[Term]
id: GO:0002564
name: alternate splicing of immunoglobulin genes
namespace: biological_process
def: "The generation of alternate transcripts of immunoglobulin genes through alternate splicing of exons." [ISBN:0781735149, PMID:9185563]
synonym: "alternate splicing of antibody genes" EXACT []
is_a: GO:0002563 ! somatic diversification of immune receptors via alternate splicing
is_a: GO:0016445 ! somatic diversification of immunoglobulins

[Term]
id: GO:0002565
name: somatic diversification of immune receptors via gene conversion
namespace: biological_process
def: "The process in which immune receptor genes are diversified through gene conversion." [GOC:add, ISBN:0781735149]
is_a: GO:0002200 ! somatic diversification of immune receptors
is_a: GO:0016444 ! somatic cell DNA recombination

[Term]
id: GO:0002566
name: somatic diversification of immune receptors via somatic mutation
namespace: biological_process
def: "The process in which immune receptor genes are diversified through somatic mutation." [ISBN:0781735149, PMID:16102575]
is_a: GO:0002200 ! somatic diversification of immune receptors

[Term]
id: GO:0002567
name: somatic diversification of FREP-based immune receptors
namespace: biological_process
def: "The process that results in the generation of sequence diversity of the FREP-based immune receptors of snails." [GOC:add, PMID:16102575]
comment: Note that this type of immune receptor has been found in snails (Pulmonata, ncbi_axonomy_id:6519), but may also be seen in other species.
is_a: GO:0002200 ! somatic diversification of immune receptors

[Term]
id: GO:0002568
name: somatic diversification of T cell receptor genes
namespace: biological_process
def: "The somatic process that results in the generation of sequence diversity of T cell receptor genes." [GOC:add, ISBN:0781735149]
synonym: "somatic diversification of TCR genes" EXACT []
is_a: GO:0002200 ! somatic diversification of immune receptors
relationship: part_of GO:0030217 ! T cell differentiation

[Term]
id: GO:0002569
name: somatic diversification of immune receptors by N region addition
namespace: biological_process
def: "The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of heavy chain immunoglobulin and T cell receptor genes. N regions are found at the V-D, D-D, V-J, and D-J recombinational junctions, depending on the immune receptor gene." [GOC:add, ISBN:0781735149]
is_a: GO:0002200 ! somatic diversification of immune receptors

[Term]
id: GO:0002570
name: somatic diversification of immunoglobulin genes by N region addition
namespace: biological_process
def: "The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of heavy chain immunoglobulin genes. N regions are found at the V-D and D-J recombinational junctions." [GOC:add, ISBN:0781735149]
synonym: "somatic diversification of antibody genes by N region addition" EXACT []
is_a: GO:0002569 ! somatic diversification of immune receptors by N region addition
is_a: GO:0016445 ! somatic diversification of immunoglobulins
relationship: part_of GO:0016447 ! somatic recombination of immunoglobulin gene segments

[Term]
id: GO:0002571
name: somatic diversification of T cell receptor genes by N region addition
namespace: biological_process
def: "The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of T cell receptor genes. N regions are found at the V-D, D-D, V-J, and D-J recombinational junctions, depending on the T cell receptor gene." [GOC:add, ISBN:0781735149]
synonym: "somatic diversification of TCR genes by N region addition" EXACT []
is_a: GO:0002568 ! somatic diversification of T cell receptor genes
is_a: GO:0002569 ! somatic diversification of immune receptors by N region addition
relationship: part_of GO:0002681 ! somatic recombination of T cell receptor gene segments

[Term]
id: GO:0002572
name: pro-T cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a pro-T cell. Pro-T cells are the earliest stage of the T cell lineage but are not fully committed." [GOC:add, ISBN:0781735149]
synonym: "pro-T lymphocyte differentiation" EXACT []
is_a: GO:0002320 ! lymphoid progenitor cell differentiation
relationship: part_of GO:0030217 ! T cell differentiation

[Term]
id: GO:0002573
name: myeloid leukocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage." [GOC:add, PMID:16551251]
synonym: "myeloid leucocyte differentiation" EXACT []
is_a: GO:0002521 ! leukocyte differentiation
is_a: GO:0030099 ! myeloid cell differentiation

[Term]
id: GO:0002574
name: thrombocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a thrombocyte, a nucleated cell found in all vertebrates but mammals involved in hemostasis." [GOC:add]
comment: Note that platelets are the non-nucleated mammalian functional equivalent of the nucleated thrombocytes of non-mammalian vertebrates and are sometimes also referred to as thrombocytes. Platelet formation in mammals is covered by the biological_process term platelet formation ; GO:0030220.
is_a: GO:0030099 ! myeloid cell differentiation

[Term]
id: GO:0002575
name: basophil chemotaxis
namespace: biological_process
def: "The movement of a basophil in response to an external stimulus." [GOC:add, PMID:11292027]
is_a: GO:0071621 ! granulocyte chemotaxis

[Term]
id: GO:0002576
name: platelet degranulation
namespace: biological_process
def: "The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet." [GOC:add]
synonym: "platelet exocytosis" EXACT []
xref: Reactome:REACT_100828 "Platelet degranulation, Oryza sativa"
xref: Reactome:REACT_102232 "Platelet degranulation, Mus musculus"
xref: Reactome:REACT_102739 "Platelet degranulation, Rattus norvegicus"
xref: Reactome:REACT_102744 "Platelet degranulation, Sus scrofa"
xref: Reactome:REACT_104057 "Platelet degranulation, Saccharomyces cerevisiae"
xref: Reactome:REACT_104856 "Platelet degranulation, Caenorhabditis elegans"
xref: Reactome:REACT_118371 "Platelet degranulation, Escherichia coli"
xref: Reactome:REACT_29845 "Platelet degranulation, Bos taurus"
xref: Reactome:REACT_30497 "Platelet degranulation, Canis familiaris"
xref: Reactome:REACT_31557 "Platelet degranulation, Gallus gallus"
xref: Reactome:REACT_318 "Platelet degranulation, Homo sapiens"
xref: Reactome:REACT_33703 "Platelet degranulation, Schizosaccharomyces pombe"
xref: Reactome:REACT_80537 "Platelet degranulation, Drosophila melanogaster"
xref: Reactome:REACT_81075 "Platelet degranulation, Xenopus tropicalis"
xref: Reactome:REACT_81265 "Platelet degranulation, Danio rerio"
xref: Reactome:REACT_81408 "Platelet degranulation, Arabidopsis thaliana"
xref: Reactome:REACT_87179 "Platelet degranulation, Plasmodium falciparum"
xref: Reactome:REACT_97581 "Platelet degranulation, Taeniopygia guttata"
xref: Reactome:REACT_99712 "Platelet degranulation, Dictyostelium discoideum"
is_a: GO:0045055 ! regulated exocytosis

[Term]
id: GO:0002577
name: regulation of antigen processing and presentation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation." [GOC:add]
is_a: GO:0002682 ! regulation of immune system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019882 ! antigen processing and presentation
relationship: regulates GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002578
name: negative regulation of antigen processing and presentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation." [GOC:add]
synonym: "down regulation of antigen processing and presentation" EXACT []
synonym: "down-regulation of antigen processing and presentation" EXACT []
synonym: "downregulation of antigen processing and presentation" EXACT []
synonym: "inhibition of antigen processing and presentation" NARROW []
is_a: GO:0002577 ! regulation of antigen processing and presentation
is_a: GO:0002683 ! negative regulation of immune system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019882 ! antigen processing and presentation
relationship: negatively_regulates GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002579
name: positive regulation of antigen processing and presentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation." [GOC:add]
synonym: "activation of antigen processing and presentation" NARROW []
synonym: "stimulation of antigen processing and presentation" NARROW []
synonym: "up regulation of antigen processing and presentation" EXACT []
synonym: "up-regulation of antigen processing and presentation" EXACT []
synonym: "upregulation of antigen processing and presentation" EXACT []
is_a: GO:0002577 ! regulation of antigen processing and presentation
is_a: GO:0002684 ! positive regulation of immune system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0019882 ! antigen processing and presentation
relationship: positively_regulates GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002580
name: regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add]
synonym: "regulation of peptide or polysaccharide antigen processing and presentation via MHC class II" EXACT []
is_a: GO:0002577 ! regulation of antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
relationship: regulates GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

[Term]
id: GO:0002581
name: negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add]
synonym: "down regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT []
synonym: "down-regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT []
synonym: "downregulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT []
synonym: "inhibition of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" NARROW []
synonym: "negative regulation of peptide or polysaccharide antigen processing and presentation via MHC class II" EXACT []
is_a: GO:0002578 ! negative regulation of antigen processing and presentation
is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
relationship: negatively_regulates GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

[Term]
id: GO:0002582
name: positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add]
synonym: "activation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" NARROW []
synonym: "positive regulation of peptide or polysaccharide antigen processing and presentation via MHC class II" EXACT []
synonym: "stimulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" NARROW []
synonym: "up regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT []
synonym: "up-regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT []
synonym: "upregulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT []
is_a: GO:0002579 ! positive regulation of antigen processing and presentation
is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
relationship: positively_regulates GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

[Term]
id: GO:0002583
name: regulation of antigen processing and presentation of peptide antigen
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen." [GOC:add]
synonym: "regulation of peptide antigen processing and presentation" EXACT []
is_a: GO:0002577 ! regulation of antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048002 ! antigen processing and presentation of peptide antigen
relationship: regulates GO:0048002 ! antigen processing and presentation of peptide antigen

[Term]
id: GO:0002584
name: negative regulation of antigen processing and presentation of peptide antigen
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen." [GOC:add]
synonym: "down regulation of antigen processing and presentation of peptide antigen" EXACT []
synonym: "down-regulation of antigen processing and presentation of peptide antigen" EXACT []
synonym: "downregulation of antigen processing and presentation of peptide antigen" EXACT []
synonym: "inhibition of antigen processing and presentation of peptide antigen" NARROW []
synonym: "negative regulation of peptide antigen processing and presentation" EXACT []
is_a: GO:0002578 ! negative regulation of antigen processing and presentation
is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048002 ! antigen processing and presentation of peptide antigen
relationship: negatively_regulates GO:0048002 ! antigen processing and presentation of peptide antigen

[Term]
id: GO:0002585
name: positive regulation of antigen processing and presentation of peptide antigen
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen." [GOC:add]
synonym: "activation of antigen processing and presentation of peptide antigen" NARROW []
synonym: "positive regulation of peptide antigen processing and presentation" EXACT []
synonym: "stimulation of antigen processing and presentation of peptide antigen" NARROW []
synonym: "up regulation of antigen processing and presentation of peptide antigen" EXACT []
synonym: "up-regulation of antigen processing and presentation of peptide antigen" EXACT []
synonym: "upregulation of antigen processing and presentation of peptide antigen" EXACT []
is_a: GO:0002579 ! positive regulation of antigen processing and presentation
is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048002 ! antigen processing and presentation of peptide antigen
relationship: positively_regulates GO:0048002 ! antigen processing and presentation of peptide antigen

[Term]
id: GO:0002586
name: regulation of antigen processing and presentation of peptide antigen via MHC class II
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II." [GOC:add]
synonym: "regulation of peptide antigen processing and presentation via MHC class II" EXACT []
is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II
relationship: regulates GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II

[Term]
id: GO:0002587
name: negative regulation of antigen processing and presentation of peptide antigen via MHC class II
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II." [GOC:add]
synonym: "down regulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT []
synonym: "down-regulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT []
synonym: "downregulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT []
synonym: "inhibition of antigen processing and presentation of peptide antigen via MHC class II" NARROW []
synonym: "negative regulation of peptide antigen processing and presentation via MHC class II" EXACT []
is_a: GO:0002581 ! negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
is_a: GO:0002584 ! negative regulation of antigen processing and presentation of peptide antigen
is_a: GO:0002586 ! regulation of antigen processing and presentation of peptide antigen via MHC class II
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II
relationship: negatively_regulates GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II

[Term]
id: GO:0002588
name: positive regulation of antigen processing and presentation of peptide antigen via MHC class II
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II." [GOC:add]
synonym: "activation of antigen processing and presentation of peptide antigen via MHC class II" NARROW []
synonym: "positive regulation of peptide antigen processing and presentation via MHC class II" EXACT []
synonym: "stimulation of antigen processing and presentation of peptide antigen via MHC class II" NARROW []
synonym: "up regulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT []
synonym: "up-regulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT []
synonym: "upregulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT []
is_a: GO:0002582 ! positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
is_a: GO:0002585 ! positive regulation of antigen processing and presentation of peptide antigen
is_a: GO:0002586 ! regulation of antigen processing and presentation of peptide antigen via MHC class II
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II
relationship: positively_regulates GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II

[Term]
id: GO:0002589
name: regulation of antigen processing and presentation of peptide antigen via MHC class I
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I." [GOC:add]
synonym: "regulation of peptide antigen processing and presentation via MHC class I" EXACT []
is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I
relationship: regulates GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I

[Term]
id: GO:0002590
name: negative regulation of antigen processing and presentation of peptide antigen via MHC class I
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I." [GOC:add]
synonym: "down regulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT []
synonym: "down-regulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT []
synonym: "downregulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT []
synonym: "inhibition of antigen processing and presentation of peptide antigen via MHC class I" NARROW []
synonym: "negative regulation of peptide antigen processing and presentation via MHC class I" EXACT []
is_a: GO:0002584 ! negative regulation of antigen processing and presentation of peptide antigen
is_a: GO:0002589 ! regulation of antigen processing and presentation of peptide antigen via MHC class I
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I
relationship: negatively_regulates GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I

[Term]
id: GO:0002591
name: positive regulation of antigen processing and presentation of peptide antigen via MHC class I
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I." [GOC:add]
synonym: "activation of antigen processing and presentation of peptide antigen via MHC class I" NARROW []
synonym: "positive regulation of peptide antigen processing and presentation via MHC class I" EXACT []
synonym: "stimulation of antigen processing and presentation of peptide antigen via MHC class I" NARROW []
synonym: "up regulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT []
synonym: "up-regulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT []
synonym: "upregulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT []
is_a: GO:0002585 ! positive regulation of antigen processing and presentation of peptide antigen
is_a: GO:0002589 ! regulation of antigen processing and presentation of peptide antigen via MHC class I
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I
relationship: positively_regulates GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I

[Term]
id: GO:0002592
name: regulation of antigen processing and presentation via MHC class Ib
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib." [GOC:add]
is_a: GO:0002577 ! regulation of antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002475 ! antigen processing and presentation via MHC class Ib
relationship: regulates GO:0002475 ! antigen processing and presentation via MHC class Ib

[Term]
id: GO:0002593
name: negative regulation of antigen processing and presentation via MHC class Ib
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib." [GOC:add]
synonym: "down regulation of antigen processing and presentation via MHC class Ib" EXACT []
synonym: "down-regulation of antigen processing and presentation via MHC class Ib" EXACT []
synonym: "downregulation of antigen processing and presentation via MHC class Ib" EXACT []
synonym: "inhibition of antigen processing and presentation via MHC class Ib" NARROW []
is_a: GO:0002578 ! negative regulation of antigen processing and presentation
is_a: GO:0002592 ! regulation of antigen processing and presentation via MHC class Ib
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002475 ! antigen processing and presentation via MHC class Ib
relationship: negatively_regulates GO:0002475 ! antigen processing and presentation via MHC class Ib

[Term]
id: GO:0002594
name: positive regulation of antigen processing and presentation via MHC class Ib
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib." [GOC:add]
synonym: "activation of antigen processing and presentation via MHC class Ib" NARROW []
synonym: "stimulation of antigen processing and presentation via MHC class Ib" NARROW []
synonym: "up regulation of antigen processing and presentation via MHC class Ib" EXACT []
synonym: "up-regulation of antigen processing and presentation via MHC class Ib" EXACT []
synonym: "upregulation of antigen processing and presentation via MHC class Ib" EXACT []
is_a: GO:0002579 ! positive regulation of antigen processing and presentation
is_a: GO:0002592 ! regulation of antigen processing and presentation via MHC class Ib
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002475 ! antigen processing and presentation via MHC class Ib
relationship: positively_regulates GO:0002475 ! antigen processing and presentation via MHC class Ib

[Term]
id: GO:0002595
name: regulation of antigen processing and presentation of peptide antigen via MHC class Ib
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib." [GOC:add]
synonym: "regulation of peptide antigen processing and presentation via MHC class Ib" EXACT []
is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen
is_a: GO:0002592 ! regulation of antigen processing and presentation via MHC class Ib
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib
relationship: regulates GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib

[Term]
id: GO:0002596
name: negative regulation of antigen processing and presentation of peptide antigen via MHC class Ib
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib." [GOC:add]
synonym: "down regulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT []
synonym: "down-regulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT []
synonym: "downregulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT []
synonym: "inhibition of antigen processing and presentation of peptide antigen via MHC class Ib" NARROW []
synonym: "negative regulation of peptide antigen processing and presentation via MHC class Ib" EXACT []
is_a: GO:0002584 ! negative regulation of antigen processing and presentation of peptide antigen
is_a: GO:0002593 ! negative regulation of antigen processing and presentation via MHC class Ib
is_a: GO:0002595 ! regulation of antigen processing and presentation of peptide antigen via MHC class Ib
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib
relationship: negatively_regulates GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib

[Term]
id: GO:0002597
name: positive regulation of antigen processing and presentation of peptide antigen via MHC class Ib
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib." [GOC:add]
synonym: "activation of antigen processing and presentation of peptide antigen via MHC class Ib" NARROW []
synonym: "positive regulation of peptide antigen processing and presentation via MHC class Ib" EXACT []
synonym: "stimulation of antigen processing and presentation of peptide antigen via MHC class Ib" NARROW []
synonym: "up regulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT []
synonym: "up-regulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT []
synonym: "upregulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT []
is_a: GO:0002585 ! positive regulation of antigen processing and presentation of peptide antigen
is_a: GO:0002594 ! positive regulation of antigen processing and presentation via MHC class Ib
is_a: GO:0002595 ! regulation of antigen processing and presentation of peptide antigen via MHC class Ib
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib
relationship: positively_regulates GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib

[Term]
id: GO:0002598
name: regulation of antigen processing and presentation of lipid antigen via MHC class Ib
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib." [GOC:add]
synonym: "regulation of lipid antigen processing and presentation via MHC class Ib" EXACT []
is_a: GO:0002592 ! regulation of antigen processing and presentation via MHC class Ib
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib
relationship: regulates GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib

[Term]
id: GO:0002599
name: negative regulation of antigen processing and presentation of lipid antigen via MHC class Ib
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib." [GOC:add]
synonym: "down regulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT []
synonym: "down-regulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT []
synonym: "downregulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT []
synonym: "inhibition of antigen processing and presentation of lipid antigen via MHC class Ib" NARROW []
synonym: "negative regulation of lipid antigen processing and presentation via MHC class Ib" EXACT []
is_a: GO:0002593 ! negative regulation of antigen processing and presentation via MHC class Ib
is_a: GO:0002598 ! regulation of antigen processing and presentation of lipid antigen via MHC class Ib
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib
relationship: negatively_regulates GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib

[Term]
id: GO:0002600
name: positive regulation of antigen processing and presentation of lipid antigen via MHC class Ib
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib." [GOC:add]
synonym: "activation of antigen processing and presentation of lipid antigen via MHC class Ib" NARROW []
synonym: "positive regulation of lipid antigen processing and presentation via MHC class Ib" EXACT []
synonym: "stimulation of antigen processing and presentation of lipid antigen via MHC class Ib" NARROW []
synonym: "up regulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT []
synonym: "up-regulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT []
synonym: "upregulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT []
is_a: GO:0002594 ! positive regulation of antigen processing and presentation via MHC class Ib
is_a: GO:0002598 ! regulation of antigen processing and presentation of lipid antigen via MHC class Ib
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib
relationship: positively_regulates GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib

[Term]
id: GO:0002601
name: regulation of antigen processing and presentation of polysaccharide antigen via MHC class II
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II." [GOC:add]
synonym: "regulation of polysaccharide antigen processing and presentation via MHC class II" EXACT []
is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002505 ! antigen processing and presentation of polysaccharide antigen via MHC class II
relationship: regulates GO:0002505 ! antigen processing and presentation of polysaccharide antigen via MHC class II

[Term]
id: GO:0002602
name: negative regulation of antigen processing and presentation of polysaccharide antigen via MHC class II
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II." [GOC:add]
synonym: "down regulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT []
synonym: "down-regulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT []
synonym: "downregulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT []
synonym: "inhibition of antigen processing and presentation of polysaccharide antigen via MHC class II" NARROW []
synonym: "negative regulation of polysaccharide antigen processing and presentation via MHC class II" EXACT []
is_a: GO:0002581 ! negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
is_a: GO:0002601 ! regulation of antigen processing and presentation of polysaccharide antigen via MHC class II
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002505 ! antigen processing and presentation of polysaccharide antigen via MHC class II
relationship: negatively_regulates GO:0002505 ! antigen processing and presentation of polysaccharide antigen via MHC class II

[Term]
id: GO:0002603
name: positive regulation of antigen processing and presentation of polysaccharide antigen via MHC class II
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II." [GOC:add]
synonym: "activation of antigen processing and presentation of polysaccharide antigen via MHC class II" NARROW []
synonym: "positive regulation of polysaccharide antigen processing and presentation via MHC class II" EXACT []
synonym: "stimulation of antigen processing and presentation of polysaccharide antigen via MHC class II" NARROW []
synonym: "up regulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT []
synonym: "up-regulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT []
synonym: "upregulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT []
is_a: GO:0002582 ! positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
is_a: GO:0002601 ! regulation of antigen processing and presentation of polysaccharide antigen via MHC class II
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002505 ! antigen processing and presentation of polysaccharide antigen via MHC class II
relationship: positively_regulates GO:0002505 ! antigen processing and presentation of polysaccharide antigen via MHC class II

[Term]
id: GO:0002604
name: regulation of dendritic cell antigen processing and presentation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add]
is_a: GO:0002577 ! regulation of antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002468 ! dendritic cell antigen processing and presentation
relationship: regulates GO:0002468 ! dendritic cell antigen processing and presentation

[Term]
id: GO:0002605
name: negative regulation of dendritic cell antigen processing and presentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add]
synonym: "down regulation of dendritic cell antigen processing and presentation" EXACT []
synonym: "down-regulation of dendritic cell antigen processing and presentation" EXACT []
synonym: "downregulation of dendritic cell antigen processing and presentation" EXACT []
synonym: "inhibition of dendritic cell antigen processing and presentation" NARROW []
is_a: GO:0002578 ! negative regulation of antigen processing and presentation
is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002468 ! dendritic cell antigen processing and presentation
relationship: negatively_regulates GO:0002468 ! dendritic cell antigen processing and presentation

[Term]
id: GO:0002606
name: positive regulation of dendritic cell antigen processing and presentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add]
synonym: "activation of dendritic cell antigen processing and presentation" NARROW []
synonym: "stimulation of dendritic cell antigen processing and presentation" NARROW []
synonym: "up regulation of dendritic cell antigen processing and presentation" EXACT []
synonym: "up-regulation of dendritic cell antigen processing and presentation" EXACT []
synonym: "upregulation of dendritic cell antigen processing and presentation" EXACT []
is_a: GO:0002579 ! positive regulation of antigen processing and presentation
is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002468 ! dendritic cell antigen processing and presentation
relationship: positively_regulates GO:0002468 ! dendritic cell antigen processing and presentation

[Term]
id: GO:0002607
name: regulation of myeloid dendritic cell antigen processing and presentation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add]
is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002469 ! myeloid dendritic cell antigen processing and presentation
relationship: regulates GO:0002469 ! myeloid dendritic cell antigen processing and presentation

[Term]
id: GO:0002608
name: negative regulation of myeloid dendritic cell antigen processing and presentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add]
synonym: "down regulation of myeloid dendritic cell antigen processing and presentation" EXACT []
synonym: "down-regulation of myeloid dendritic cell antigen processing and presentation" EXACT []
synonym: "downregulation of myeloid dendritic cell antigen processing and presentation" EXACT []
synonym: "inhibition of myeloid dendritic cell antigen processing and presentation" NARROW []
is_a: GO:0002605 ! negative regulation of dendritic cell antigen processing and presentation
is_a: GO:0002607 ! regulation of myeloid dendritic cell antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002469 ! myeloid dendritic cell antigen processing and presentation
relationship: negatively_regulates GO:0002469 ! myeloid dendritic cell antigen processing and presentation

[Term]
id: GO:0002609
name: positive regulation of myeloid dendritic cell antigen processing and presentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add]
synonym: "activation of myeloid dendritic cell antigen processing and presentation" NARROW []
synonym: "stimulation of myeloid dendritic cell antigen processing and presentation" NARROW []
synonym: "up regulation of myeloid dendritic cell antigen processing and presentation" EXACT []
synonym: "up-regulation of myeloid dendritic cell antigen processing and presentation" EXACT []
synonym: "upregulation of myeloid dendritic cell antigen processing and presentation" EXACT []
is_a: GO:0002606 ! positive regulation of dendritic cell antigen processing and presentation
is_a: GO:0002607 ! regulation of myeloid dendritic cell antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002469 ! myeloid dendritic cell antigen processing and presentation
relationship: positively_regulates GO:0002469 ! myeloid dendritic cell antigen processing and presentation

[Term]
id: GO:0002610
name: regulation of plasmacytoid dendritic cell antigen processing and presentation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation." [GOC:add]
is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002470 ! plasmacytoid dendritic cell antigen processing and presentation
relationship: regulates GO:0002470 ! plasmacytoid dendritic cell antigen processing and presentation

[Term]
id: GO:0002611
name: negative regulation of plasmacytoid dendritic cell antigen processing and presentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation." [GOC:add]
synonym: "down regulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT []
synonym: "down-regulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT []
synonym: "downregulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT []
synonym: "inhibition of plasmacytoid dendritic cell antigen processing and presentation" NARROW []
is_a: GO:0002605 ! negative regulation of dendritic cell antigen processing and presentation
is_a: GO:0002610 ! regulation of plasmacytoid dendritic cell antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002470 ! plasmacytoid dendritic cell antigen processing and presentation
relationship: negatively_regulates GO:0002470 ! plasmacytoid dendritic cell antigen processing and presentation

[Term]
id: GO:0002612
name: positive regulation of plasmacytoid dendritic cell antigen processing and presentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation." [GOC:add]
synonym: "activation of plasmacytoid dendritic cell antigen processing and presentation" NARROW []
synonym: "stimulation of plasmacytoid dendritic cell antigen processing and presentation" NARROW []
synonym: "up regulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT []
synonym: "up-regulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT []
synonym: "upregulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT []
is_a: GO:0002606 ! positive regulation of dendritic cell antigen processing and presentation
is_a: GO:0002610 ! regulation of plasmacytoid dendritic cell antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002470 ! plasmacytoid dendritic cell antigen processing and presentation
relationship: positively_regulates GO:0002470 ! plasmacytoid dendritic cell antigen processing and presentation

[Term]
id: GO:0002613
name: regulation of monocyte antigen processing and presentation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add]
is_a: GO:0002577 ! regulation of antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002471 ! monocyte antigen processing and presentation
relationship: regulates GO:0002471 ! monocyte antigen processing and presentation

[Term]
id: GO:0002614
name: negative regulation of monocyte antigen processing and presentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add]
synonym: "down regulation of monocyte antigen processing and presentation" EXACT []
synonym: "down-regulation of monocyte antigen processing and presentation" EXACT []
synonym: "downregulation of monocyte antigen processing and presentation" EXACT []
synonym: "inhibition of monocyte antigen processing and presentation" NARROW []
is_a: GO:0002578 ! negative regulation of antigen processing and presentation
is_a: GO:0002613 ! regulation of monocyte antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002471 ! monocyte antigen processing and presentation
relationship: negatively_regulates GO:0002471 ! monocyte antigen processing and presentation

[Term]
id: GO:0002615
name: positive regulation of monocyte antigen processing and presentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add]
synonym: "activation of monocyte antigen processing and presentation" NARROW []
synonym: "stimulation of monocyte antigen processing and presentation" NARROW []
synonym: "up regulation of monocyte antigen processing and presentation" EXACT []
synonym: "up-regulation of monocyte antigen processing and presentation" EXACT []
synonym: "upregulation of monocyte antigen processing and presentation" EXACT []
is_a: GO:0002579 ! positive regulation of antigen processing and presentation
is_a: GO:0002613 ! regulation of monocyte antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002471 ! monocyte antigen processing and presentation
relationship: positively_regulates GO:0002471 ! monocyte antigen processing and presentation

[Term]
id: GO:0002616
name: regulation of macrophage antigen processing and presentation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add]
is_a: GO:0002577 ! regulation of antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002472 ! macrophage antigen processing and presentation
relationship: regulates GO:0002472 ! macrophage antigen processing and presentation

[Term]
id: GO:0002617
name: negative regulation of macrophage antigen processing and presentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add]
synonym: "down regulation of macrophage antigen processing and presentation" EXACT []
synonym: "down-regulation of macrophage antigen processing and presentation" EXACT []
synonym: "downregulation of macrophage antigen processing and presentation" EXACT []
synonym: "inhibition of macrophage antigen processing and presentation" NARROW []
is_a: GO:0002578 ! negative regulation of antigen processing and presentation
is_a: GO:0002616 ! regulation of macrophage antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002472 ! macrophage antigen processing and presentation
relationship: negatively_regulates GO:0002472 ! macrophage antigen processing and presentation

[Term]
id: GO:0002618
name: positive regulation of macrophage antigen processing and presentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add]
synonym: "activation of macrophage antigen processing and presentation" NARROW []
synonym: "stimulation of macrophage antigen processing and presentation" NARROW []
synonym: "up regulation of macrophage antigen processing and presentation" EXACT []
synonym: "up-regulation of macrophage antigen processing and presentation" EXACT []
synonym: "upregulation of macrophage antigen processing and presentation" EXACT []
is_a: GO:0002579 ! positive regulation of antigen processing and presentation
is_a: GO:0002616 ! regulation of macrophage antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002472 ! macrophage antigen processing and presentation
relationship: positively_regulates GO:0002472 ! macrophage antigen processing and presentation

[Term]
id: GO:0002619
name: regulation of non-professional antigen presenting cell antigen processing and presentation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation." [GOC:add]
is_a: GO:0002577 ! regulation of antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002473 ! non-professional antigen presenting cell antigen processing and presentation
relationship: regulates GO:0002473 ! non-professional antigen presenting cell antigen processing and presentation

[Term]
id: GO:0002620
name: negative regulation of non-professional antigen presenting cell antigen processing and presentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation." [GOC:add]
synonym: "down regulation of non-professional antigen presenting cell antigen processing and presentation" EXACT []
synonym: "down-regulation of non-professional antigen presenting cell antigen processing and presentation" EXACT []
synonym: "downregulation of non-professional antigen presenting cell antigen processing and presentation" EXACT []
synonym: "inhibition of non-professional antigen presenting cell antigen processing and presentation" NARROW []
is_a: GO:0002578 ! negative regulation of antigen processing and presentation
is_a: GO:0002619 ! regulation of non-professional antigen presenting cell antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002473 ! non-professional antigen presenting cell antigen processing and presentation
relationship: negatively_regulates GO:0002473 ! non-professional antigen presenting cell antigen processing and presentation

[Term]
id: GO:0002621
name: positive regulation of non-professional antigen presenting cell antigen processing and presentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation." [GOC:add]
synonym: "activation of non-professional antigen presenting cell antigen processing and presentation" NARROW []
synonym: "stimulation of non-professional antigen presenting cell antigen processing and presentation" NARROW []
synonym: "up regulation of non-professional antigen presenting cell antigen processing and presentation" EXACT []
synonym: "up-regulation of non-professional antigen presenting cell antigen processing and presentation" EXACT []
synonym: "upregulation of non-professional antigen presenting cell antigen processing and presentation" EXACT []
is_a: GO:0002579 ! positive regulation of antigen processing and presentation
is_a: GO:0002619 ! regulation of non-professional antigen presenting cell antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002473 ! non-professional antigen presenting cell antigen processing and presentation
relationship: positively_regulates GO:0002473 ! non-professional antigen presenting cell antigen processing and presentation

[Term]
id: GO:0002622
name: regulation of B cell antigen processing and presentation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of B cell antigen processing and presentation." [GOC:add]
synonym: "regulation of B lymphocyte antigen processing and presentation" EXACT []
synonym: "regulation of B-cell antigen processing and presentation" EXACT []
synonym: "regulation of B-lymphocyte antigen processing and presentation" EXACT []
is_a: GO:0002577 ! regulation of antigen processing and presentation
is_a: GO:0002712 ! regulation of B cell mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002450 ! B cell antigen processing and presentation
relationship: regulates GO:0002450 ! B cell antigen processing and presentation

[Term]
id: GO:0002623
name: negative regulation of B cell antigen processing and presentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell antigen processing and presentation." [GOC:add]
synonym: "down regulation of B cell antigen processing and presentation" EXACT []
synonym: "down-regulation of B cell antigen processing and presentation" EXACT []
synonym: "downregulation of B cell antigen processing and presentation" EXACT []
synonym: "inhibition of B cell antigen processing and presentation" NARROW []
synonym: "negative regulation of B lymphocyte antigen processing and presentation" EXACT []
synonym: "negative regulation of B-cell antigen processing and presentation" EXACT []
synonym: "negative regulation of B-lymphocyte antigen processing and presentation" EXACT []
is_a: GO:0002578 ! negative regulation of antigen processing and presentation
is_a: GO:0002622 ! regulation of B cell antigen processing and presentation
is_a: GO:0002713 ! negative regulation of B cell mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002450 ! B cell antigen processing and presentation
relationship: negatively_regulates GO:0002450 ! B cell antigen processing and presentation

[Term]
id: GO:0002624
name: positive regulation of B cell antigen processing and presentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of B cell antigen processing and presentation." [GOC:add]
synonym: "activation of B cell antigen processing and presentation" NARROW []
synonym: "positive regulation of B lymphocyte antigen processing and presentation" EXACT []
synonym: "positive regulation of B-cell antigen processing and presentation" EXACT []
synonym: "positive regulation of B-lymphocyte antigen processing and presentation" EXACT []
synonym: "stimulation of B cell antigen processing and presentation" NARROW []
synonym: "up regulation of B cell antigen processing and presentation" EXACT []
synonym: "up-regulation of B cell antigen processing and presentation" EXACT []
synonym: "upregulation of B cell antigen processing and presentation" EXACT []
is_a: GO:0002579 ! positive regulation of antigen processing and presentation
is_a: GO:0002622 ! regulation of B cell antigen processing and presentation
is_a: GO:0002714 ! positive regulation of B cell mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002450 ! B cell antigen processing and presentation
relationship: positively_regulates GO:0002450 ! B cell antigen processing and presentation

[Term]
id: GO:0002625
name: regulation of T cell antigen processing and presentation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add]
synonym: "regulation of T lymphocyte antigen processing and presentation" EXACT []
synonym: "regulation of T-cell antigen processing and presentation" EXACT []
synonym: "regulation of T-lymphocyte antigen processing and presentation" EXACT []
is_a: GO:0002577 ! regulation of antigen processing and presentation
is_a: GO:0002709 ! regulation of T cell mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002457 ! T cell antigen processing and presentation
relationship: regulates GO:0002457 ! T cell antigen processing and presentation

[Term]
id: GO:0002626
name: negative regulation of T cell antigen processing and presentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add]
synonym: "down regulation of T cell antigen processing and presentation" EXACT []
synonym: "down-regulation of T cell antigen processing and presentation" EXACT []
synonym: "downregulation of T cell antigen processing and presentation" EXACT []
synonym: "inhibition of T cell antigen processing and presentation" NARROW []
synonym: "negative regulation of T lymphocyte antigen processing and presentation" EXACT []
synonym: "negative regulation of T-cell antigen processing and presentation" EXACT []
synonym: "negative regulation of T-lymphocyte antigen processing and presentation" EXACT []
is_a: GO:0002578 ! negative regulation of antigen processing and presentation
is_a: GO:0002625 ! regulation of T cell antigen processing and presentation
is_a: GO:0002710 ! negative regulation of T cell mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002457 ! T cell antigen processing and presentation
relationship: negatively_regulates GO:0002457 ! T cell antigen processing and presentation

[Term]
id: GO:0002627
name: positive regulation of T cell antigen processing and presentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add]
synonym: "activation of T cell antigen processing and presentation" NARROW []
synonym: "positive regulation of T lymphocyte antigen processing and presentation" EXACT []
synonym: "positive regulation of T-cell antigen processing and presentation" EXACT []
synonym: "positive regulation of T-lymphocyte antigen processing and presentation" EXACT []
synonym: "stimulation of T cell antigen processing and presentation" NARROW []
synonym: "up regulation of T cell antigen processing and presentation" EXACT []
synonym: "up-regulation of T cell antigen processing and presentation" EXACT []
synonym: "upregulation of T cell antigen processing and presentation" EXACT []
is_a: GO:0002579 ! positive regulation of antigen processing and presentation
is_a: GO:0002625 ! regulation of T cell antigen processing and presentation
is_a: GO:0002711 ! positive regulation of T cell mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002457 ! T cell antigen processing and presentation
relationship: positively_regulates GO:0002457 ! T cell antigen processing and presentation

[Term]
id: GO:0002628
name: regulation of proteolysis associated with antigen processing and presentation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of proteolysis associated with antigen processing and presentation." [GOC:add]
is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen
is_a: GO:1903050 ! regulation of proteolysis involved in cellular protein catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002496 ! proteolysis associated with antigen processing and presentation
relationship: regulates GO:0002496 ! proteolysis associated with antigen processing and presentation

[Term]
id: GO:0002629
name: negative regulation of proteolysis associated with antigen processing and presentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of proteolysis associated with antigen processing and presentation." [GOC:add]
synonym: "down regulation of proteolysis associated with antigen processing and presentation" EXACT []
synonym: "down-regulation of proteolysis associated with antigen processing and presentation" EXACT []
synonym: "downregulation of proteolysis associated with antigen processing and presentation" EXACT []
synonym: "inhibition of proteolysis associated with antigen processing and presentation" NARROW []
is_a: GO:0002584 ! negative regulation of antigen processing and presentation of peptide antigen
is_a: GO:0002628 ! regulation of proteolysis associated with antigen processing and presentation
is_a: GO:1903051 ! negative regulation of proteolysis involved in cellular protein catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002496 ! proteolysis associated with antigen processing and presentation
relationship: negatively_regulates GO:0002496 ! proteolysis associated with antigen processing and presentation

[Term]
id: GO:0002630
name: positive regulation of proteolysis associated with antigen processing and presentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of proteolysis associated with antigen processing and presentation." [GOC:add]
synonym: "activation of proteolysis associated with antigen processing and presentation" NARROW []
synonym: "stimulation of proteolysis associated with antigen processing and presentation" NARROW []
synonym: "up regulation of proteolysis associated with antigen processing and presentation" EXACT []
synonym: "up-regulation of proteolysis associated with antigen processing and presentation" EXACT []
synonym: "upregulation of proteolysis associated with antigen processing and presentation" EXACT []
is_a: GO:0002585 ! positive regulation of antigen processing and presentation of peptide antigen
is_a: GO:0002628 ! regulation of proteolysis associated with antigen processing and presentation
is_a: GO:1903052 ! positive regulation of proteolysis involved in cellular protein catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002496 ! proteolysis associated with antigen processing and presentation
relationship: positively_regulates GO:0002496 ! proteolysis associated with antigen processing and presentation

[Term]
id: GO:0002631
name: regulation of granuloma formation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of granuloma formation." [GOC:add]
is_a: GO:0002676 ! regulation of chronic inflammatory response
is_a: GO:0002697 ! regulation of immune effector process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002432 ! granuloma formation
relationship: regulates GO:0002432 ! granuloma formation

[Term]
id: GO:0002632
name: negative regulation of granuloma formation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of granuloma formation." [GOC:add]
synonym: "down regulation of granuloma formation" EXACT []
synonym: "down-regulation of granuloma formation" EXACT []
synonym: "downregulation of granuloma formation" EXACT []
synonym: "inhibition of granuloma formation" NARROW []
is_a: GO:0002631 ! regulation of granuloma formation
is_a: GO:0002677 ! negative regulation of chronic inflammatory response
is_a: GO:0002698 ! negative regulation of immune effector process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002432 ! granuloma formation
relationship: negatively_regulates GO:0002432 ! granuloma formation

[Term]
id: GO:0002633
name: positive regulation of granuloma formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of granuloma formation." [GOC:add]
synonym: "activation of granuloma formation" NARROW []
synonym: "stimulation of granuloma formation" NARROW []
synonym: "up regulation of granuloma formation" EXACT []
synonym: "up-regulation of granuloma formation" EXACT []
synonym: "upregulation of granuloma formation" EXACT []
is_a: GO:0002631 ! regulation of granuloma formation
is_a: GO:0002678 ! positive regulation of chronic inflammatory response
is_a: GO:0002699 ! positive regulation of immune effector process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002432 ! granuloma formation
relationship: positively_regulates GO:0002432 ! granuloma formation

[Term]
id: GO:0002634
name: regulation of germinal center formation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of germinal center formation." [GOC:add]
is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002467 ! germinal center formation
relationship: regulates GO:0002467 ! germinal center formation

[Term]
id: GO:0002635
name: negative regulation of germinal center formation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of germinal center formation." [GOC:add]
synonym: "down regulation of germinal center formation" EXACT []
synonym: "down-regulation of germinal center formation" EXACT []
synonym: "downregulation of germinal center formation" EXACT []
synonym: "inhibition of germinal center formation" NARROW []
is_a: GO:0002634 ! regulation of germinal center formation
is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
is_a: GO:0051093 ! negative regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002467 ! germinal center formation
relationship: negatively_regulates GO:0002467 ! germinal center formation

[Term]
id: GO:0002636
name: positive regulation of germinal center formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of germinal center formation." [GOC:add]
synonym: "activation of germinal center formation" NARROW []
synonym: "stimulation of germinal center formation" NARROW []
synonym: "up regulation of germinal center formation" EXACT []
synonym: "up-regulation of germinal center formation" EXACT []
synonym: "upregulation of germinal center formation" EXACT []
is_a: GO:0002634 ! regulation of germinal center formation
is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
is_a: GO:0051094 ! positive regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002467 ! germinal center formation
relationship: positively_regulates GO:0002467 ! germinal center formation

[Term]
id: GO:0002637
name: regulation of immunoglobulin production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of immunoglobulin production." [GOC:add]
is_a: GO:0002700 ! regulation of production of molecular mediator of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002377 ! immunoglobulin production
relationship: regulates GO:0002377 ! immunoglobulin production

[Term]
id: GO:0002638
name: negative regulation of immunoglobulin production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of immunoglobulin production." [GOC:add]
synonym: "down regulation of immunoglobulin production" EXACT []
synonym: "down-regulation of immunoglobulin production" EXACT []
synonym: "downregulation of immunoglobulin production" EXACT []
synonym: "inhibition of immunoglobulin production" NARROW []
is_a: GO:0002637 ! regulation of immunoglobulin production
is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002377 ! immunoglobulin production
relationship: negatively_regulates GO:0002377 ! immunoglobulin production

[Term]
id: GO:0002639
name: positive regulation of immunoglobulin production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of immunoglobulin production." [GOC:add]
synonym: "activation of immunoglobulin production" NARROW []
synonym: "stimulation of immunoglobulin production" NARROW []
synonym: "up regulation of immunoglobulin production" EXACT []
synonym: "up-regulation of immunoglobulin production" EXACT []
synonym: "upregulation of immunoglobulin production" EXACT []
is_a: GO:0002637 ! regulation of immunoglobulin production
is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002377 ! immunoglobulin production
relationship: positively_regulates GO:0002377 ! immunoglobulin production

[Term]
id: GO:0002640
name: regulation of immunoglobulin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of immunoglobulin biosynthesis." [GOC:add]
is_a: GO:0002637 ! regulation of immunoglobulin production
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002378 ! immunoglobulin biosynthetic process
relationship: regulates GO:0002378 ! immunoglobulin biosynthetic process

[Term]
id: GO:0002641
name: negative regulation of immunoglobulin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of immunoglobulin biosynthesis." [GOC:add]
synonym: "down regulation of immunoglobulin biosynthetic process" EXACT []
synonym: "down-regulation of immunoglobulin biosynthetic process" EXACT []
synonym: "downregulation of immunoglobulin biosynthetic process" EXACT []
synonym: "inhibition of immunoglobulin biosynthetic process" NARROW []
is_a: GO:0002638 ! negative regulation of immunoglobulin production
is_a: GO:0002640 ! regulation of immunoglobulin biosynthetic process
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002378 ! immunoglobulin biosynthetic process
relationship: negatively_regulates GO:0002378 ! immunoglobulin biosynthetic process

[Term]
id: GO:0002642
name: positive regulation of immunoglobulin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of immunoglobulin biosynthesis." [GOC:add]
synonym: "activation of immunoglobulin biosynthetic process" NARROW []
synonym: "stimulation of immunoglobulin biosynthetic process" NARROW []
synonym: "up regulation of immunoglobulin biosynthetic process" EXACT []
synonym: "up-regulation of immunoglobulin biosynthetic process" EXACT []
synonym: "upregulation of immunoglobulin biosynthetic process" EXACT []
is_a: GO:0002639 ! positive regulation of immunoglobulin production
is_a: GO:0002640 ! regulation of immunoglobulin biosynthetic process
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002378 ! immunoglobulin biosynthetic process
relationship: positively_regulates GO:0002378 ! immunoglobulin biosynthetic process

[Term]
id: GO:0002643
name: regulation of tolerance induction
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of tolerance induction." [GOC:add]
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002507 ! tolerance induction
relationship: regulates GO:0002507 ! tolerance induction

[Term]
id: GO:0002644
name: negative regulation of tolerance induction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction." [GOC:add]
synonym: "down regulation of tolerance induction" EXACT []
synonym: "down-regulation of tolerance induction" EXACT []
synonym: "downregulation of tolerance induction" EXACT []
synonym: "inhibition of tolerance induction" NARROW []
is_a: GO:0002643 ! regulation of tolerance induction
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002507 ! tolerance induction
relationship: negatively_regulates GO:0002507 ! tolerance induction

[Term]
id: GO:0002645
name: positive regulation of tolerance induction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction." [GOC:add]
synonym: "activation of tolerance induction" NARROW []
synonym: "stimulation of tolerance induction" NARROW []
synonym: "up regulation of tolerance induction" EXACT []
synonym: "up-regulation of tolerance induction" EXACT []
synonym: "upregulation of tolerance induction" EXACT []
is_a: GO:0002643 ! regulation of tolerance induction
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002507 ! tolerance induction
relationship: positively_regulates GO:0002507 ! tolerance induction

[Term]
id: GO:0002646
name: regulation of central tolerance induction
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of central tolerance induction." [GOC:add]
is_a: GO:0002643 ! regulation of tolerance induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002508 ! central tolerance induction
relationship: regulates GO:0002508 ! central tolerance induction

[Term]
id: GO:0002647
name: negative regulation of central tolerance induction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of central tolerance induction." [GOC:add]
synonym: "down regulation of central tolerance induction" EXACT []
synonym: "down-regulation of central tolerance induction" EXACT []
synonym: "downregulation of central tolerance induction" EXACT []
synonym: "inhibition of central tolerance induction" NARROW []
is_a: GO:0002644 ! negative regulation of tolerance induction
is_a: GO:0002646 ! regulation of central tolerance induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002508 ! central tolerance induction
relationship: negatively_regulates GO:0002508 ! central tolerance induction

[Term]
id: GO:0002648
name: positive regulation of central tolerance induction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of central tolerance induction." [GOC:add]
synonym: "activation of central tolerance induction" NARROW []
synonym: "stimulation of central tolerance induction" NARROW []
synonym: "up regulation of central tolerance induction" EXACT []
synonym: "up-regulation of central tolerance induction" EXACT []
synonym: "upregulation of central tolerance induction" EXACT []
is_a: GO:0002645 ! positive regulation of tolerance induction
is_a: GO:0002646 ! regulation of central tolerance induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002508 ! central tolerance induction
relationship: positively_regulates GO:0002508 ! central tolerance induction

[Term]
id: GO:0002649
name: regulation of tolerance induction to self antigen
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of tolerance induction to self antigen." [GOC:add]
is_a: GO:0002643 ! regulation of tolerance induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002513 ! tolerance induction to self antigen
relationship: regulates GO:0002513 ! tolerance induction to self antigen

[Term]
id: GO:0002650
name: negative regulation of tolerance induction to self antigen
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to self antigen." [GOC:add]
synonym: "down regulation of tolerance induction to self antigen" EXACT []
synonym: "down-regulation of tolerance induction to self antigen" EXACT []
synonym: "downregulation of tolerance induction to self antigen" EXACT []
synonym: "inhibition of tolerance induction to self antigen" NARROW []
is_a: GO:0002644 ! negative regulation of tolerance induction
is_a: GO:0002649 ! regulation of tolerance induction to self antigen
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002513 ! tolerance induction to self antigen
relationship: negatively_regulates GO:0002513 ! tolerance induction to self antigen

[Term]
id: GO:0002651
name: positive regulation of tolerance induction to self antigen
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction to self antigen." [GOC:add]
synonym: "activation of tolerance induction to self antigen" NARROW []
synonym: "stimulation of tolerance induction to self antigen" NARROW []
synonym: "up regulation of tolerance induction to self antigen" EXACT []
synonym: "up-regulation of tolerance induction to self antigen" EXACT []
synonym: "upregulation of tolerance induction to self antigen" EXACT []
is_a: GO:0002645 ! positive regulation of tolerance induction
is_a: GO:0002649 ! regulation of tolerance induction to self antigen
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002513 ! tolerance induction to self antigen
relationship: positively_regulates GO:0002513 ! tolerance induction to self antigen

[Term]
id: GO:0002652
name: regulation of tolerance induction dependent upon immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of tolerance induction dependent upon immune response." [GOC:add]
synonym: "regulation of immune response-dependent tolerance induction" EXACT []
is_a: GO:0002643 ! regulation of tolerance induction
is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002461 ! tolerance induction dependent upon immune response
relationship: regulates GO:0002461 ! tolerance induction dependent upon immune response

[Term]
id: GO:0002653
name: negative regulation of tolerance induction dependent upon immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction dependent upon immune response." [GOC:add]
synonym: "down regulation of tolerance induction dependent upon immune response" EXACT []
synonym: "down-regulation of tolerance induction dependent upon immune response" EXACT []
synonym: "downregulation of tolerance induction dependent upon immune response" EXACT []
synonym: "inhibition of tolerance induction dependent upon immune response" NARROW []
synonym: "negative regulation of immune response-dependent tolerance induction" EXACT []
is_a: GO:0002644 ! negative regulation of tolerance induction
is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response
is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002461 ! tolerance induction dependent upon immune response
relationship: negatively_regulates GO:0002461 ! tolerance induction dependent upon immune response

[Term]
id: GO:0002654
name: positive regulation of tolerance induction dependent upon immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction dependent upon immune response." [GOC:add]
synonym: "activation of tolerance induction dependent upon immune response" NARROW []
synonym: "positive regulation of immune response-dependent tolerance induction" EXACT []
synonym: "stimulation of tolerance induction dependent upon immune response" NARROW []
synonym: "up regulation of tolerance induction dependent upon immune response" EXACT []
synonym: "up-regulation of tolerance induction dependent upon immune response" EXACT []
synonym: "upregulation of tolerance induction dependent upon immune response" EXACT []
is_a: GO:0002645 ! positive regulation of tolerance induction
is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response
is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002461 ! tolerance induction dependent upon immune response
relationship: positively_regulates GO:0002461 ! tolerance induction dependent upon immune response

[Term]
id: GO:0002655
name: regulation of tolerance induction to nonself antigen
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of tolerance induction to nonself antigen." [GOC:add]
is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002462 ! tolerance induction to nonself antigen
relationship: regulates GO:0002462 ! tolerance induction to nonself antigen

[Term]
id: GO:0002656
name: negative regulation of tolerance induction to nonself antigen
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to nonself antigen." [GOC:add]
synonym: "down regulation of tolerance induction to nonself antigen" EXACT []
synonym: "down-regulation of tolerance induction to nonself antigen" EXACT []
synonym: "downregulation of tolerance induction to nonself antigen" EXACT []
synonym: "inhibition of tolerance induction to nonself antigen" NARROW []
is_a: GO:0002653 ! negative regulation of tolerance induction dependent upon immune response
is_a: GO:0002655 ! regulation of tolerance induction to nonself antigen
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002462 ! tolerance induction to nonself antigen
relationship: negatively_regulates GO:0002462 ! tolerance induction to nonself antigen

[Term]
id: GO:0002657
name: positive regulation of tolerance induction to nonself antigen
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction to nonself antigen." [GOC:add]
synonym: "activation of tolerance induction to nonself antigen" NARROW []
synonym: "stimulation of tolerance induction to nonself antigen" NARROW []
synonym: "up regulation of tolerance induction to nonself antigen" EXACT []
synonym: "up-regulation of tolerance induction to nonself antigen" EXACT []
synonym: "upregulation of tolerance induction to nonself antigen" EXACT []
is_a: GO:0002654 ! positive regulation of tolerance induction dependent upon immune response
is_a: GO:0002655 ! regulation of tolerance induction to nonself antigen
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002462 ! tolerance induction to nonself antigen
relationship: positively_regulates GO:0002462 ! tolerance induction to nonself antigen

[Term]
id: GO:0002658
name: regulation of peripheral tolerance induction
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of peripheral tolerance induction." [GOC:add]
is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002465 ! peripheral tolerance induction
relationship: regulates GO:0002465 ! peripheral tolerance induction

[Term]
id: GO:0002659
name: negative regulation of peripheral tolerance induction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral tolerance induction." [GOC:add]
synonym: "down regulation of peripheral tolerance induction" EXACT []
synonym: "down-regulation of peripheral tolerance induction" EXACT []
synonym: "downregulation of peripheral tolerance induction" EXACT []
synonym: "inhibition of peripheral tolerance induction" NARROW []
is_a: GO:0002653 ! negative regulation of tolerance induction dependent upon immune response
is_a: GO:0002658 ! regulation of peripheral tolerance induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002465 ! peripheral tolerance induction
relationship: negatively_regulates GO:0002465 ! peripheral tolerance induction

[Term]
id: GO:0002660
name: positive regulation of peripheral tolerance induction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of peripheral tolerance induction." [GOC:add]
synonym: "activation of peripheral tolerance induction" NARROW []
synonym: "stimulation of peripheral tolerance induction" NARROW []
synonym: "up regulation of peripheral tolerance induction" EXACT []
synonym: "up-regulation of peripheral tolerance induction" EXACT []
synonym: "upregulation of peripheral tolerance induction" EXACT []
is_a: GO:0002654 ! positive regulation of tolerance induction dependent upon immune response
is_a: GO:0002658 ! regulation of peripheral tolerance induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002465 ! peripheral tolerance induction
relationship: positively_regulates GO:0002465 ! peripheral tolerance induction

[Term]
id: GO:0002661
name: regulation of B cell tolerance induction
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of B cell tolerance induction." [GOC:add]
synonym: "regulation of B lymphocyte tolerance induction" EXACT []
synonym: "regulation of B-cell tolerance induction" EXACT []
synonym: "regulation of B-lymphocyte tolerance induction" EXACT []
is_a: GO:0002643 ! regulation of tolerance induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002514 ! B cell tolerance induction
relationship: regulates GO:0002514 ! B cell tolerance induction

[Term]
id: GO:0002662
name: negative regulation of B cell tolerance induction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell tolerance induction." [GOC:add]
synonym: "down regulation of B cell tolerance induction" EXACT []
synonym: "down-regulation of B cell tolerance induction" EXACT []
synonym: "downregulation of B cell tolerance induction" EXACT []
synonym: "inhibition of B cell tolerance induction" NARROW []
synonym: "negative regulation of B lymphocyte tolerance induction" EXACT []
synonym: "negative regulation of B-cell tolerance induction" EXACT []
synonym: "negative regulation of B-lymphocyte tolerance induction" EXACT []
is_a: GO:0002644 ! negative regulation of tolerance induction
is_a: GO:0002661 ! regulation of B cell tolerance induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002514 ! B cell tolerance induction
relationship: negatively_regulates GO:0002514 ! B cell tolerance induction

[Term]
id: GO:0002663
name: positive regulation of B cell tolerance induction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of B cell tolerance induction." [GOC:add]
synonym: "activation of B cell tolerance induction" NARROW []
synonym: "positive regulation of B lymphocyte tolerance induction" EXACT []
synonym: "positive regulation of B-cell tolerance induction" EXACT []
synonym: "positive regulation of B-lymphocyte tolerance induction" EXACT []
synonym: "stimulation of B cell tolerance induction" NARROW []
synonym: "up regulation of B cell tolerance induction" EXACT []
synonym: "up-regulation of B cell tolerance induction" EXACT []
synonym: "upregulation of B cell tolerance induction" EXACT []
is_a: GO:0002645 ! positive regulation of tolerance induction
is_a: GO:0002661 ! regulation of B cell tolerance induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002514 ! B cell tolerance induction
relationship: positively_regulates GO:0002514 ! B cell tolerance induction

[Term]
id: GO:0002664
name: regulation of T cell tolerance induction
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of T cell tolerance induction." [GOC:add]
synonym: "regulation of T lymphocyte tolerance induction" EXACT []
synonym: "regulation of T-cell tolerance induction" EXACT []
synonym: "regulation of T-lymphocyte tolerance induction" EXACT []
is_a: GO:0002643 ! regulation of tolerance induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002517 ! T cell tolerance induction
relationship: regulates GO:0002517 ! T cell tolerance induction

[Term]
id: GO:0002665
name: negative regulation of T cell tolerance induction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell tolerance induction." [GOC:add]
synonym: "down regulation of T cell tolerance induction" EXACT []
synonym: "down-regulation of T cell tolerance induction" EXACT []
synonym: "downregulation of T cell tolerance induction" EXACT []
synonym: "inhibition of T cell tolerance induction" NARROW []
synonym: "negative regulation of T lymphocyte tolerance induction" EXACT []
synonym: "negative regulation of T-cell tolerance induction" EXACT []
synonym: "negative regulation of T-lymphocyte tolerance induction" EXACT []
is_a: GO:0002644 ! negative regulation of tolerance induction
is_a: GO:0002664 ! regulation of T cell tolerance induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002517 ! T cell tolerance induction
relationship: negatively_regulates GO:0002517 ! T cell tolerance induction

[Term]
id: GO:0002666
name: positive regulation of T cell tolerance induction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction." [GOC:add]
synonym: "activation of T cell tolerance induction" NARROW []
synonym: "positive regulation of T lymphocyte tolerance induction" EXACT []
synonym: "positive regulation of T-cell tolerance induction" EXACT []
synonym: "positive regulation of T-lymphocyte tolerance induction" EXACT []
synonym: "stimulation of T cell tolerance induction" NARROW []
synonym: "up regulation of T cell tolerance induction" EXACT []
synonym: "up-regulation of T cell tolerance induction" EXACT []
synonym: "upregulation of T cell tolerance induction" EXACT []
is_a: GO:0002645 ! positive regulation of tolerance induction
is_a: GO:0002664 ! regulation of T cell tolerance induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002517 ! T cell tolerance induction
relationship: positively_regulates GO:0002517 ! T cell tolerance induction

[Term]
id: GO:0002667
name: regulation of T cell anergy
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of T cell anergy." [GOC:add]
synonym: "regulation of T lymphocyte anergy" EXACT []
synonym: "regulation of T-cell anergy" EXACT []
synonym: "regulation of T-lymphocyte anergy" EXACT []
is_a: GO:0002664 ! regulation of T cell tolerance induction
is_a: GO:0002911 ! regulation of lymphocyte anergy
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002870 ! T cell anergy
relationship: regulates GO:0002870 ! T cell anergy

[Term]
id: GO:0002668
name: negative regulation of T cell anergy
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell anergy." [GOC:add]
synonym: "down regulation of T cell anergy" EXACT []
synonym: "down-regulation of T cell anergy" EXACT []
synonym: "downregulation of T cell anergy" EXACT []
synonym: "inhibition of T cell anergy" NARROW []
synonym: "negative regulation of T lymphocyte anergy" EXACT []
synonym: "negative regulation of T-cell anergy" EXACT []
synonym: "negative regulation of T-lymphocyte anergy" EXACT []
is_a: GO:0002665 ! negative regulation of T cell tolerance induction
is_a: GO:0002667 ! regulation of T cell anergy
is_a: GO:0002912 ! negative regulation of lymphocyte anergy
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002870 ! T cell anergy
relationship: negatively_regulates GO:0002870 ! T cell anergy

[Term]
id: GO:0002669
name: positive regulation of T cell anergy
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of T cell anergy." [GOC:add]
synonym: "activation of T cell anergy" NARROW []
synonym: "positive regulation of T lymphocyte anergy" EXACT []
synonym: "positive regulation of T-cell anergy" EXACT []
synonym: "positive regulation of T-lymphocyte anergy" EXACT []
synonym: "stimulation of T cell anergy" NARROW []
synonym: "up regulation of T cell anergy" EXACT []
synonym: "up-regulation of T cell anergy" EXACT []
synonym: "upregulation of T cell anergy" EXACT []
is_a: GO:0002666 ! positive regulation of T cell tolerance induction
is_a: GO:0002667 ! regulation of T cell anergy
is_a: GO:0002913 ! positive regulation of lymphocyte anergy
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002870 ! T cell anergy
relationship: positively_regulates GO:0002870 ! T cell anergy

[Term]
id: GO:0002670
name: regulation of B cell anergy
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of B cell anergy." [GOC:add]
synonym: "regulation of B lymphocyte anergy" EXACT []
synonym: "regulation of B-cell anergy" EXACT []
synonym: "regulation of B-lymphocyte anergy" EXACT []
is_a: GO:0002661 ! regulation of B cell tolerance induction
is_a: GO:0002911 ! regulation of lymphocyte anergy
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002515 ! B cell anergy
relationship: regulates GO:0002515 ! B cell anergy

[Term]
id: GO:0002671
name: negative regulation of B cell anergy
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell anergy." [GOC:add]
synonym: "down regulation of B cell anergy" EXACT []
synonym: "down-regulation of B cell anergy" EXACT []
synonym: "downregulation of B cell anergy" EXACT []
synonym: "inhibition of B cell anergy" NARROW []
synonym: "negative regulation of B lymphocyte anergy" EXACT []
synonym: "negative regulation of B-cell anergy" EXACT []
synonym: "negative regulation of B-lymphocyte anergy" EXACT []
is_a: GO:0002662 ! negative regulation of B cell tolerance induction
is_a: GO:0002670 ! regulation of B cell anergy
is_a: GO:0002912 ! negative regulation of lymphocyte anergy
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002515 ! B cell anergy
relationship: negatively_regulates GO:0002515 ! B cell anergy

[Term]
id: GO:0002672
name: positive regulation of B cell anergy
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of B cell anergy." [GOC:add]
synonym: "activation of B cell anergy" NARROW []
synonym: "positive regulation of B lymphocyte anergy" EXACT []
synonym: "positive regulation of B-cell anergy" EXACT []
synonym: "positive regulation of B-lymphocyte anergy" EXACT []
synonym: "stimulation of B cell anergy" NARROW []
synonym: "up regulation of B cell anergy" EXACT []
synonym: "up-regulation of B cell anergy" EXACT []
synonym: "upregulation of B cell anergy" EXACT []
is_a: GO:0002663 ! positive regulation of B cell tolerance induction
is_a: GO:0002670 ! regulation of B cell anergy
is_a: GO:0002913 ! positive regulation of lymphocyte anergy
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002515 ! B cell anergy
relationship: positively_regulates GO:0002515 ! B cell anergy

[Term]
id: GO:0002673
name: regulation of acute inflammatory response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an acute inflammatory response." [GOC:add]
is_a: GO:0050727 ! regulation of inflammatory response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002526 ! acute inflammatory response
relationship: regulates GO:0002526 ! acute inflammatory response

[Term]
id: GO:0002674
name: negative regulation of acute inflammatory response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response." [GOC:add]
synonym: "down regulation of acute inflammatory response" EXACT []
synonym: "down-regulation of acute inflammatory response" EXACT []
synonym: "downregulation of acute inflammatory response" EXACT []
synonym: "inhibition of acute inflammatory response" NARROW []
is_a: GO:0002673 ! regulation of acute inflammatory response
is_a: GO:0050728 ! negative regulation of inflammatory response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002526 ! acute inflammatory response
relationship: negatively_regulates GO:0002526 ! acute inflammatory response

[Term]
id: GO:0002675
name: positive regulation of acute inflammatory response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response." [GOC:add]
synonym: "activation of acute inflammatory response" NARROW []
synonym: "stimulation of acute inflammatory response" NARROW []
synonym: "up regulation of acute inflammatory response" EXACT []
synonym: "up-regulation of acute inflammatory response" EXACT []
synonym: "upregulation of acute inflammatory response" EXACT []
is_a: GO:0002673 ! regulation of acute inflammatory response
is_a: GO:0050729 ! positive regulation of inflammatory response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002526 ! acute inflammatory response
relationship: positively_regulates GO:0002526 ! acute inflammatory response

[Term]
id: GO:0002676
name: regulation of chronic inflammatory response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a chronic inflammatory response." [GOC:add]
is_a: GO:0050727 ! regulation of inflammatory response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002544 ! chronic inflammatory response
relationship: regulates GO:0002544 ! chronic inflammatory response

[Term]
id: GO:0002677
name: negative regulation of chronic inflammatory response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response." [GOC:add]
synonym: "down regulation of chronic inflammatory response" EXACT []
synonym: "down-regulation of chronic inflammatory response" EXACT []
synonym: "downregulation of chronic inflammatory response" EXACT []
synonym: "inhibition of chronic inflammatory response" NARROW []
is_a: GO:0002676 ! regulation of chronic inflammatory response
is_a: GO:0050728 ! negative regulation of inflammatory response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002544 ! chronic inflammatory response
relationship: negatively_regulates GO:0002544 ! chronic inflammatory response

[Term]
id: GO:0002678
name: positive regulation of chronic inflammatory response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response." [GOC:add]
synonym: "activation of chronic inflammatory response" NARROW []
synonym: "stimulation of chronic inflammatory response" NARROW []
synonym: "up regulation of chronic inflammatory response" EXACT []
synonym: "up-regulation of chronic inflammatory response" EXACT []
synonym: "upregulation of chronic inflammatory response" EXACT []
is_a: GO:0002676 ! regulation of chronic inflammatory response
is_a: GO:0050729 ! positive regulation of inflammatory response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002544 ! chronic inflammatory response
relationship: positively_regulates GO:0002544 ! chronic inflammatory response

[Term]
id: GO:0002679
name: respiratory burst involved in defense response
namespace: biological_process
def: "A phase of elevated metabolic activity, during which oxygen consumption increases made as part of a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:add, ISBN:0781735149, PMID:12789499]
is_a: GO:0002252 ! immune effector process
is_a: GO:0045730 ! respiratory burst
intersection_of: GO:0045730 ! respiratory burst
intersection_of: part_of GO:0006952 ! defense response
relationship: part_of GO:0006952 ! defense response

[Term]
id: GO:0002680
name: pro-T cell lineage commitment
namespace: biological_process
def: "The process in which a lymphoid progenitor cell becomes committed to becoming a pro-T cell." [GOC:add, ISBN:0781735149]
synonym: "pro-T cell fate commitment" EXACT []
synonym: "pro-T lymphocyte fate commitment" EXACT []
synonym: "pro-T lymphocyte lineage commitment" EXACT []
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0002572 ! pro-T cell differentiation

[Term]
id: GO:0002681
name: somatic recombination of T cell receptor gene segments
namespace: biological_process
def: "The process in which T cell receptor genes are formed through recombination of the germline genetic elements, also known as T cell receptor gene segments." [GOC:add, ISBN:0781735149]
synonym: "somatic recombination of TCR gene segments" EXACT []
is_a: GO:0002562 ! somatic diversification of immune receptors via germline recombination within a single locus
is_a: GO:0002568 ! somatic diversification of T cell receptor genes

[Term]
id: GO:0002682
name: regulation of immune system process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an immune system process." [GOC:add]
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002376 ! immune system process
relationship: regulates GO:0002376 ! immune system process

[Term]
id: GO:0002683
name: negative regulation of immune system process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process." [GOC:add]
synonym: "down regulation of immune system process" EXACT []
synonym: "down-regulation of immune system process" EXACT []
synonym: "downregulation of immune system process" EXACT []
synonym: "inhibition of immune system process" NARROW []
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0048519 ! negative regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002376 ! immune system process
relationship: negatively_regulates GO:0002376 ! immune system process

[Term]
id: GO:0002684
name: positive regulation of immune system process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of an immune system process." [GOC:add]
synonym: "activation of immune system process" NARROW []
synonym: "stimulation of immune system process" NARROW []
synonym: "up regulation of immune system process" EXACT []
synonym: "up-regulation of immune system process" EXACT []
synonym: "upregulation of immune system process" EXACT []
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0048518 ! positive regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002376 ! immune system process
relationship: positively_regulates GO:0002376 ! immune system process

[Term]
id: GO:0002685
name: regulation of leukocyte migration
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of leukocyte migration." [GOC:add]
synonym: "regulation of immune cell migration" EXACT []
synonym: "regulation of leucocyte migration" EXACT []
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0030334 ! regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050900 ! leukocyte migration
relationship: regulates GO:0050900 ! leukocyte migration

[Term]
id: GO:0002686
name: negative regulation of leukocyte migration
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration." [GOC:add]
synonym: "down regulation of leukocyte migration" EXACT []
synonym: "down-regulation of leukocyte migration" EXACT []
synonym: "downregulation of leukocyte migration" EXACT []
synonym: "inhibition of leukocyte migration" NARROW []
synonym: "negative regulation of immune cell migration" EXACT []
synonym: "negative regulation of leucocyte migration" EXACT []
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0002685 ! regulation of leukocyte migration
is_a: GO:0030336 ! negative regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0050900 ! leukocyte migration
relationship: negatively_regulates GO:0050900 ! leukocyte migration

[Term]
id: GO:0002687
name: positive regulation of leukocyte migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of leukocyte migration." [GOC:add]
synonym: "activation of leukocyte migration" NARROW []
synonym: "positive regulation of immune cell migration" EXACT []
synonym: "positive regulation of leucocyte migration" EXACT []
synonym: "stimulation of leukocyte migration" NARROW []
synonym: "up regulation of leukocyte migration" EXACT []
synonym: "up-regulation of leukocyte migration" EXACT []
synonym: "upregulation of leukocyte migration" EXACT []
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0002685 ! regulation of leukocyte migration
is_a: GO:0030335 ! positive regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0050900 ! leukocyte migration
relationship: positively_regulates GO:0050900 ! leukocyte migration

[Term]
id: GO:0002688
name: regulation of leukocyte chemotaxis
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of leukocyte chemotaxis." [GOC:add]
synonym: "regulation of immune cell chemotaxis" EXACT []
synonym: "regulation of leucocyte chemotaxis" EXACT []
is_a: GO:0002685 ! regulation of leukocyte migration
is_a: GO:0050920 ! regulation of chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030595 ! leukocyte chemotaxis
relationship: regulates GO:0030595 ! leukocyte chemotaxis

[Term]
id: GO:0002689
name: negative regulation of leukocyte chemotaxis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis." [GOC:add]
synonym: "down regulation of leukocyte chemotaxis" EXACT []
synonym: "down-regulation of leukocyte chemotaxis" EXACT []
synonym: "downregulation of leukocyte chemotaxis" EXACT []
synonym: "inhibition of leukocyte chemotaxis" NARROW []
synonym: "negative regulation of immune cell chemotaxis" EXACT []
synonym: "negative regulation of leucocyte chemotaxis" EXACT []
is_a: GO:0002686 ! negative regulation of leukocyte migration
is_a: GO:0002688 ! regulation of leukocyte chemotaxis
is_a: GO:0050922 ! negative regulation of chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030595 ! leukocyte chemotaxis
relationship: negatively_regulates GO:0030595 ! leukocyte chemotaxis

[Term]
id: GO:0002690
name: positive regulation of leukocyte chemotaxis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis." [GOC:add]
synonym: "activation of leukocyte chemotaxis" NARROW []
synonym: "positive regulation of immune cell chemotaxis" EXACT []
synonym: "positive regulation of leucocyte chemotaxis" EXACT []
synonym: "stimulation of leukocyte chemotaxis" NARROW []
synonym: "up regulation of leukocyte chemotaxis" EXACT []
synonym: "up-regulation of leukocyte chemotaxis" EXACT []
synonym: "upregulation of leukocyte chemotaxis" EXACT []
is_a: GO:0002687 ! positive regulation of leukocyte migration
is_a: GO:0002688 ! regulation of leukocyte chemotaxis
is_a: GO:0050921 ! positive regulation of chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030595 ! leukocyte chemotaxis
relationship: positively_regulates GO:0030595 ! leukocyte chemotaxis

[Term]
id: GO:0002691
name: regulation of cellular extravasation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of cellular extravasation." [GOC:add]
is_a: GO:0002685 ! regulation of leukocyte migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045123 ! cellular extravasation
relationship: regulates GO:0045123 ! cellular extravasation

[Term]
id: GO:0002692
name: negative regulation of cellular extravasation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cellular extravasation." [GOC:add]
synonym: "down regulation of cellular extravasation" EXACT []
synonym: "down-regulation of cellular extravasation" EXACT []
synonym: "downregulation of cellular extravasation" EXACT []
synonym: "inhibition of cellular extravasation" NARROW []
is_a: GO:0002686 ! negative regulation of leukocyte migration
is_a: GO:0002691 ! regulation of cellular extravasation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045123 ! cellular extravasation
relationship: negatively_regulates GO:0045123 ! cellular extravasation

[Term]
id: GO:0002693
name: positive regulation of cellular extravasation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of cellular extravasation." [GOC:add]
synonym: "activation of cellular extravasation" NARROW []
synonym: "stimulation of cellular extravasation" NARROW []
synonym: "up regulation of cellular extravasation" EXACT []
synonym: "up-regulation of cellular extravasation" EXACT []
synonym: "upregulation of cellular extravasation" EXACT []
is_a: GO:0002687 ! positive regulation of leukocyte migration
is_a: GO:0002691 ! regulation of cellular extravasation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045123 ! cellular extravasation
relationship: positively_regulates GO:0045123 ! cellular extravasation

[Term]
id: GO:0002694
name: regulation of leukocyte activation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of leukocyte activation." [GOC:add]
synonym: "regulation of immune cell activation" EXACT []
synonym: "regulation of leucocyte activation" EXACT []
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0050865 ! regulation of cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045321 ! leukocyte activation
relationship: regulates GO:0045321 ! leukocyte activation

[Term]
id: GO:0002695
name: negative regulation of leukocyte activation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte activation." [GOC:add]
synonym: "down regulation of leukocyte activation" EXACT []
synonym: "down-regulation of leukocyte activation" EXACT []
synonym: "downregulation of leukocyte activation" EXACT []
synonym: "inhibition of leukocyte activation" NARROW []
synonym: "negative regulation of immune cell activation" EXACT []
synonym: "negative regulation of leucocyte activation" EXACT []
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0002694 ! regulation of leukocyte activation
is_a: GO:0050866 ! negative regulation of cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045321 ! leukocyte activation
relationship: negatively_regulates GO:0045321 ! leukocyte activation

[Term]
id: GO:0002696
name: positive regulation of leukocyte activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of leukocyte activation." [GOC:add]
synonym: "activation of leukocyte activation" NARROW []
synonym: "positive regulation of immune cell activation" EXACT []
synonym: "positive regulation of leucocyte activation" EXACT []
synonym: "stimulation of leukocyte activation" NARROW []
synonym: "up regulation of leukocyte activation" EXACT []
synonym: "up-regulation of leukocyte activation" EXACT []
synonym: "upregulation of leukocyte activation" EXACT []
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0002694 ! regulation of leukocyte activation
is_a: GO:0050867 ! positive regulation of cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045321 ! leukocyte activation
relationship: positively_regulates GO:0045321 ! leukocyte activation

[Term]
id: GO:0002697
name: regulation of immune effector process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an immune effector process." [GOC:add]
is_a: GO:0002682 ! regulation of immune system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002252 ! immune effector process
relationship: regulates GO:0002252 ! immune effector process

[Term]
id: GO:0002698
name: negative regulation of immune effector process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process." [GOC:add]
synonym: "down regulation of immune effector process" EXACT []
synonym: "down-regulation of immune effector process" EXACT []
synonym: "downregulation of immune effector process" EXACT []
synonym: "inhibition of immune effector process" NARROW []
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0002697 ! regulation of immune effector process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002252 ! immune effector process
relationship: negatively_regulates GO:0002252 ! immune effector process

[Term]
id: GO:0002699
name: positive regulation of immune effector process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of an immune effector process." [GOC:add]
synonym: "activation of immune effector process" NARROW []
synonym: "stimulation of immune effector process" NARROW []
synonym: "up regulation of immune effector process" EXACT []
synonym: "up-regulation of immune effector process" EXACT []
synonym: "upregulation of immune effector process" EXACT []
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0002697 ! regulation of immune effector process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002252 ! immune effector process
relationship: positively_regulates GO:0002252 ! immune effector process

[Term]
id: GO:0002700
name: regulation of production of molecular mediator of immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add]
is_a: GO:0002697 ! regulation of immune effector process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002440 ! production of molecular mediator of immune response
relationship: regulates GO:0002440 ! production of molecular mediator of immune response

[Term]
id: GO:0002701
name: negative regulation of production of molecular mediator of immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add]
synonym: "down regulation of production of molecular mediator of immune response" EXACT []
synonym: "down-regulation of production of molecular mediator of immune response" EXACT []
synonym: "downregulation of production of molecular mediator of immune response" EXACT []
synonym: "inhibition of production of molecular mediator of immune response" NARROW []
is_a: GO:0002698 ! negative regulation of immune effector process
is_a: GO:0002700 ! regulation of production of molecular mediator of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002440 ! production of molecular mediator of immune response
relationship: negatively_regulates GO:0002440 ! production of molecular mediator of immune response

[Term]
id: GO:0002702
name: positive regulation of production of molecular mediator of immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add]
synonym: "activation of production of molecular mediator of immune response" NARROW []
synonym: "stimulation of production of molecular mediator of immune response" NARROW []
synonym: "up regulation of production of molecular mediator of immune response" EXACT []
synonym: "up-regulation of production of molecular mediator of immune response" EXACT []
synonym: "upregulation of production of molecular mediator of immune response" EXACT []
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0002700 ! regulation of production of molecular mediator of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002440 ! production of molecular mediator of immune response
relationship: positively_regulates GO:0002440 ! production of molecular mediator of immune response

[Term]
id: GO:0002703
name: regulation of leukocyte mediated immunity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add]
synonym: "regulation of immune cell mediated immunity" EXACT []
synonym: "regulation of leucocyte mediated immunity" EXACT []
is_a: GO:0002697 ! regulation of immune effector process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002443 ! leukocyte mediated immunity
relationship: regulates GO:0002443 ! leukocyte mediated immunity

[Term]
id: GO:0002704
name: negative regulation of leukocyte mediated immunity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add]
synonym: "down regulation of leukocyte mediated immunity" EXACT []
synonym: "down-regulation of leukocyte mediated immunity" EXACT []
synonym: "downregulation of leukocyte mediated immunity" EXACT []
synonym: "inhibition of leukocyte mediated immunity" NARROW []
synonym: "negative regulation of immune cell mediated immunity" EXACT []
synonym: "negative regulation of leucocyte mediated immunity" EXACT []
is_a: GO:0002698 ! negative regulation of immune effector process
is_a: GO:0002703 ! regulation of leukocyte mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002443 ! leukocyte mediated immunity
relationship: negatively_regulates GO:0002443 ! leukocyte mediated immunity

[Term]
id: GO:0002705
name: positive regulation of leukocyte mediated immunity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add]
synonym: "activation of leukocyte mediated immunity" NARROW []
synonym: "positive regulation of immune cell mediated immunity" EXACT []
synonym: "positive regulation of leucocyte mediated immunity" EXACT []
synonym: "stimulation of leukocyte mediated immunity" NARROW []
synonym: "up regulation of leukocyte mediated immunity" EXACT []
synonym: "up-regulation of leukocyte mediated immunity" EXACT []
synonym: "upregulation of leukocyte mediated immunity" EXACT []
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0002703 ! regulation of leukocyte mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002443 ! leukocyte mediated immunity
relationship: positively_regulates GO:0002443 ! leukocyte mediated immunity

[Term]
id: GO:0002706
name: regulation of lymphocyte mediated immunity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add]
is_a: GO:0002703 ! regulation of leukocyte mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002449 ! lymphocyte mediated immunity
relationship: regulates GO:0002449 ! lymphocyte mediated immunity

[Term]
id: GO:0002707
name: negative regulation of lymphocyte mediated immunity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add]
synonym: "down regulation of lymphocyte mediated immunity" EXACT []
synonym: "down-regulation of lymphocyte mediated immunity" EXACT []
synonym: "downregulation of lymphocyte mediated immunity" EXACT []
synonym: "inhibition of lymphocyte mediated immunity" NARROW []
is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity
is_a: GO:0002706 ! regulation of lymphocyte mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002449 ! lymphocyte mediated immunity
relationship: negatively_regulates GO:0002449 ! lymphocyte mediated immunity

[Term]
id: GO:0002708
name: positive regulation of lymphocyte mediated immunity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add]
synonym: "activation of lymphocyte mediated immunity" NARROW []
synonym: "stimulation of lymphocyte mediated immunity" NARROW []
synonym: "up regulation of lymphocyte mediated immunity" EXACT []
synonym: "up-regulation of lymphocyte mediated immunity" EXACT []
synonym: "upregulation of lymphocyte mediated immunity" EXACT []
is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity
is_a: GO:0002706 ! regulation of lymphocyte mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002449 ! lymphocyte mediated immunity
relationship: positively_regulates GO:0002449 ! lymphocyte mediated immunity

[Term]
id: GO:0002709
name: regulation of T cell mediated immunity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of T cell mediated immunity." [GOC:add]
synonym: "regulation of T lymphocyte mediated immunity" EXACT []
synonym: "regulation of T-cell mediated immunity" EXACT []
synonym: "regulation of T-lymphocyte mediated immunity" EXACT []
is_a: GO:0002706 ! regulation of lymphocyte mediated immunity
is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002456 ! T cell mediated immunity
relationship: regulates GO:0002456 ! T cell mediated immunity

[Term]
id: GO:0002710
name: negative regulation of T cell mediated immunity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity." [GOC:add]
synonym: "down regulation of T cell mediated immunity" EXACT []
synonym: "down-regulation of T cell mediated immunity" EXACT []
synonym: "downregulation of T cell mediated immunity" EXACT []
synonym: "inhibition of T cell mediated immunity" NARROW []
synonym: "negative regulation of T lymphocyte mediated immunity" EXACT []
synonym: "negative regulation of T-cell mediated immunity" EXACT []
synonym: "negative regulation of T-lymphocyte mediated immunity" EXACT []
is_a: GO:0002707 ! negative regulation of lymphocyte mediated immunity
is_a: GO:0002709 ! regulation of T cell mediated immunity
is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002456 ! T cell mediated immunity
relationship: negatively_regulates GO:0002456 ! T cell mediated immunity

[Term]
id: GO:0002711
name: positive regulation of T cell mediated immunity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of T cell mediated immunity." [GOC:add]
synonym: "activation of T cell mediated immunity" NARROW []
synonym: "positive regulation of T lymphocyte mediated immunity" EXACT []
synonym: "positive regulation of T-cell mediated immunity" EXACT []
synonym: "positive regulation of T-lymphocyte mediated immunity" EXACT []
synonym: "stimulation of T cell mediated immunity" NARROW []
synonym: "up regulation of T cell mediated immunity" EXACT []
synonym: "up-regulation of T cell mediated immunity" EXACT []
synonym: "upregulation of T cell mediated immunity" EXACT []
is_a: GO:0002708 ! positive regulation of lymphocyte mediated immunity
is_a: GO:0002709 ! regulation of T cell mediated immunity
is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002456 ! T cell mediated immunity
relationship: positively_regulates GO:0002456 ! T cell mediated immunity

[Term]
id: GO:0002712
name: regulation of B cell mediated immunity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of B cell mediated immunity." [GOC:add]
synonym: "regulation of B lymphocyte mediated immunity" EXACT []
synonym: "regulation of B-cell mediated immunity" EXACT []
synonym: "regulation of B-lymphocyte mediated immunity" EXACT []
is_a: GO:0002706 ! regulation of lymphocyte mediated immunity
is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019724 ! B cell mediated immunity
relationship: regulates GO:0019724 ! B cell mediated immunity

[Term]
id: GO:0002713
name: negative regulation of B cell mediated immunity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell mediated immunity." [GOC:add]
synonym: "down regulation of B cell mediated immunity" EXACT []
synonym: "down-regulation of B cell mediated immunity" EXACT []
synonym: "downregulation of B cell mediated immunity" EXACT []
synonym: "inhibition of B cell mediated immunity" NARROW []
synonym: "negative regulation of B lymphocyte mediated immunity" EXACT []
synonym: "negative regulation of B-cell mediated immunity" EXACT []
synonym: "negative regulation of B-lymphocyte mediated immunity" EXACT []
is_a: GO:0002707 ! negative regulation of lymphocyte mediated immunity
is_a: GO:0002712 ! regulation of B cell mediated immunity
is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019724 ! B cell mediated immunity
relationship: negatively_regulates GO:0019724 ! B cell mediated immunity

[Term]
id: GO:0002714
name: positive regulation of B cell mediated immunity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of B cell mediated immunity." [GOC:add]
synonym: "activation of B cell mediated immunity" NARROW []
synonym: "positive regulation of B lymphocyte mediated immunity" EXACT []
synonym: "positive regulation of B-cell mediated immunity" EXACT []
synonym: "positive regulation of B-lymphocyte mediated immunity" EXACT []
synonym: "stimulation of B cell mediated immunity" NARROW []
synonym: "up regulation of B cell mediated immunity" EXACT []
synonym: "up-regulation of B cell mediated immunity" EXACT []
synonym: "upregulation of B cell mediated immunity" EXACT []
is_a: GO:0002708 ! positive regulation of lymphocyte mediated immunity
is_a: GO:0002712 ! regulation of B cell mediated immunity
is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0019724 ! B cell mediated immunity
relationship: positively_regulates GO:0019724 ! B cell mediated immunity

[Term]
id: GO:0002715
name: regulation of natural killer cell mediated immunity
namespace: biological_process
alt_id: GO:0045845
def: "Any process that modulates the frequency, rate, or extent of natural killer cell mediated immunity." [GOC:add]
synonym: "regulation of natural killer cell activity" RELATED []
synonym: "regulation of NK cell mediated immunity" EXACT []
is_a: GO:0002706 ! regulation of lymphocyte mediated immunity
is_a: GO:0045088 ! regulation of innate immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002228 ! natural killer cell mediated immunity
relationship: regulates GO:0002228 ! natural killer cell mediated immunity

[Term]
id: GO:0002716
name: negative regulation of natural killer cell mediated immunity
namespace: biological_process
alt_id: GO:0030102
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immunity." [GOC:add]
synonym: "down regulation of natural killer cell mediated immunity" EXACT []
synonym: "down-regulation of natural killer cell mediated immunity" EXACT []
synonym: "downregulation of natural killer cell mediated immunity" EXACT []
synonym: "inhibition of natural killer cell mediated immunity" NARROW []
synonym: "negative regulation of natural killer cell activity" RELATED []
synonym: "negative regulation of NK cell activity" RELATED []
synonym: "negative regulation of NK cell mediated immunity" EXACT []
is_a: GO:0002707 ! negative regulation of lymphocyte mediated immunity
is_a: GO:0002715 ! regulation of natural killer cell mediated immunity
is_a: GO:0045824 ! negative regulation of innate immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002228 ! natural killer cell mediated immunity
relationship: negatively_regulates GO:0002228 ! natural killer cell mediated immunity

[Term]
id: GO:0002717
name: positive regulation of natural killer cell mediated immunity
namespace: biological_process
alt_id: GO:0045846
def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immunity." [GOC:add]
synonym: "activation of natural killer cell mediated immunity" NARROW []
synonym: "positive regulation of natural killer cell activity" RELATED []
synonym: "positive regulation of NK cell activity" RELATED []
synonym: "positive regulation of NK cell mediated immunity" EXACT []
synonym: "stimulation of natural killer cell mediated immunity" NARROW []
synonym: "up regulation of natural killer cell mediated immunity" EXACT []
synonym: "up-regulation of natural killer cell mediated immunity" EXACT []
synonym: "upregulation of natural killer cell mediated immunity" EXACT []
is_a: GO:0002708 ! positive regulation of lymphocyte mediated immunity
is_a: GO:0002715 ! regulation of natural killer cell mediated immunity
is_a: GO:0045089 ! positive regulation of innate immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002228 ! natural killer cell mediated immunity
relationship: positively_regulates GO:0002228 ! natural killer cell mediated immunity

[Term]
id: GO:0002718
name: regulation of cytokine production involved in immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of cytokine production that contributes to an immune response." [GOC:add]
synonym: "regulation of cytokine production during immune response" RELATED [GOC:dph]
is_a: GO:0001817 ! regulation of cytokine production
is_a: GO:0002700 ! regulation of production of molecular mediator of immune response
is_a: GO:0050776 ! regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002367 ! cytokine production involved in immune response
relationship: regulates GO:0002367 ! cytokine production involved in immune response

[Term]
id: GO:0002719
name: negative regulation of cytokine production involved in immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production contributing to an immune response." [GOC:add]
synonym: "down regulation of cytokine production during immune response" RELATED []
synonym: "down-regulation of cytokine production during immune response" EXACT []
synonym: "downregulation of cytokine production during immune response" RELATED []
synonym: "inhibition of cytokine production during immune response" RELATED []
synonym: "negative regulation of cytokine production during immune response" RELATED [GOC:dph]
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response
is_a: GO:0002718 ! regulation of cytokine production involved in immune response
is_a: GO:0050777 ! negative regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002367 ! cytokine production involved in immune response
relationship: negatively_regulates GO:0002367 ! cytokine production involved in immune response

[Term]
id: GO:0002720
name: positive regulation of cytokine production involved in immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response." [GOC:add]
synonym: "activation of cytokine production during immune response" NARROW []
synonym: "positive regulation of cytokine production during immune response" RELATED [GOC:dph]
synonym: "stimulation of cytokine production during immune response" NARROW []
synonym: "up regulation of cytokine production during immune response" RELATED []
synonym: "up-regulation of cytokine production during immune response" RELATED []
synonym: "upregulation of cytokine production during immune response" RELATED []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response
is_a: GO:0002718 ! regulation of cytokine production involved in immune response
is_a: GO:0050778 ! positive regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002367 ! cytokine production involved in immune response
relationship: positively_regulates GO:0002367 ! cytokine production involved in immune response

[Term]
id: GO:0002721
name: regulation of B cell cytokine production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of B cell cytokine production." [GOC:add]
synonym: "regulation of B lymphocyte cytokine production" EXACT []
synonym: "regulation of B-cell cytokine production" EXACT []
synonym: "regulation of B-lymphocyte cytokine production" EXACT []
is_a: GO:0002712 ! regulation of B cell mediated immunity
is_a: GO:0002718 ! regulation of cytokine production involved in immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002368 ! B cell cytokine production
relationship: regulates GO:0002368 ! B cell cytokine production

[Term]
id: GO:0002722
name: negative regulation of B cell cytokine production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell cytokine production." [GOC:add]
synonym: "down regulation of B cell cytokine production" EXACT []
synonym: "down-regulation of B cell cytokine production" EXACT []
synonym: "downregulation of B cell cytokine production" EXACT []
synonym: "inhibition of B cell cytokine production" NARROW []
synonym: "negative regulation of B lymphocyte cytokine production" EXACT []
synonym: "negative regulation of B-cell cytokine production" EXACT []
synonym: "negative regulation of B-lymphocyte cytokine production" EXACT []
is_a: GO:0002713 ! negative regulation of B cell mediated immunity
is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response
is_a: GO:0002721 ! regulation of B cell cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002368 ! B cell cytokine production
relationship: negatively_regulates GO:0002368 ! B cell cytokine production

[Term]
id: GO:0002723
name: positive regulation of B cell cytokine production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of B cell cytokine production." [GOC:add]
synonym: "activation of B cell cytokine production" NARROW []
synonym: "positive regulation of B lymphocyte cytokine production" EXACT []
synonym: "positive regulation of B-cell cytokine production" EXACT []
synonym: "positive regulation of B-lymphocyte cytokine production" EXACT []
synonym: "stimulation of B cell cytokine production" NARROW []
synonym: "up regulation of B cell cytokine production" EXACT []
synonym: "up-regulation of B cell cytokine production" EXACT []
synonym: "upregulation of B cell cytokine production" EXACT []
is_a: GO:0002714 ! positive regulation of B cell mediated immunity
is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response
is_a: GO:0002721 ! regulation of B cell cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002368 ! B cell cytokine production
relationship: positively_regulates GO:0002368 ! B cell cytokine production

[Term]
id: GO:0002724
name: regulation of T cell cytokine production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of T cell cytokine production." [GOC:add]
synonym: "regulation of T lymphocyte cytokine production" EXACT []
synonym: "regulation of T-cell cytokine production" EXACT []
synonym: "regulation of T-lymphocyte cytokine production" EXACT []
is_a: GO:0002709 ! regulation of T cell mediated immunity
is_a: GO:0002718 ! regulation of cytokine production involved in immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002369 ! T cell cytokine production
relationship: regulates GO:0002369 ! T cell cytokine production

[Term]
id: GO:0002725
name: negative regulation of T cell cytokine production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell cytokine production." [GOC:add]
synonym: "down regulation of T cell cytokine production" EXACT []
synonym: "down-regulation of T cell cytokine production" EXACT []
synonym: "downregulation of T cell cytokine production" EXACT []
synonym: "inhibition of T cell cytokine production" NARROW []
synonym: "negative regulation of T lymphocyte cytokine production" EXACT []
synonym: "negative regulation of T-cell cytokine production" EXACT []
synonym: "negative regulation of T-lymphocyte cytokine production" EXACT []
is_a: GO:0002710 ! negative regulation of T cell mediated immunity
is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response
is_a: GO:0002724 ! regulation of T cell cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002369 ! T cell cytokine production
relationship: negatively_regulates GO:0002369 ! T cell cytokine production

[Term]
id: GO:0002726
name: positive regulation of T cell cytokine production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of T cell cytokine production." [GOC:add]
synonym: "activation of T cell cytokine production" NARROW []
synonym: "positive regulation of T lymphocyte cytokine production" EXACT []
synonym: "positive regulation of T-cell cytokine production" EXACT []
synonym: "positive regulation of T-lymphocyte cytokine production" EXACT []
synonym: "stimulation of T cell cytokine production" NARROW []
synonym: "up regulation of T cell cytokine production" EXACT []
synonym: "up-regulation of T cell cytokine production" EXACT []
synonym: "upregulation of T cell cytokine production" EXACT []
is_a: GO:0002711 ! positive regulation of T cell mediated immunity
is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response
is_a: GO:0002724 ! regulation of T cell cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002369 ! T cell cytokine production
relationship: positively_regulates GO:0002369 ! T cell cytokine production

[Term]
id: GO:0002727
name: regulation of natural killer cell cytokine production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of natural killer cell cytokine production." [GOC:add]
synonym: "regulation of NK cell cytokine production" EXACT []
is_a: GO:0002715 ! regulation of natural killer cell mediated immunity
is_a: GO:0002718 ! regulation of cytokine production involved in immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002370 ! natural killer cell cytokine production
relationship: regulates GO:0002370 ! natural killer cell cytokine production

[Term]
id: GO:0002728
name: negative regulation of natural killer cell cytokine production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell cytokine production." [GOC:add]
synonym: "down regulation of natural killer cell cytokine production" EXACT []
synonym: "down-regulation of natural killer cell cytokine production" EXACT []
synonym: "downregulation of natural killer cell cytokine production" EXACT []
synonym: "inhibition of natural killer cell cytokine production" NARROW []
synonym: "negative regulation of NK cell cytokine production" EXACT []
is_a: GO:0002716 ! negative regulation of natural killer cell mediated immunity
is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response
is_a: GO:0002727 ! regulation of natural killer cell cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002370 ! natural killer cell cytokine production
relationship: negatively_regulates GO:0002370 ! natural killer cell cytokine production

[Term]
id: GO:0002729
name: positive regulation of natural killer cell cytokine production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell cytokine production." [GOC:add]
synonym: "activation of natural killer cell cytokine production" NARROW []
synonym: "positive regulation of NK cell cytokine production" EXACT []
synonym: "stimulation of natural killer cell cytokine production" NARROW []
synonym: "up regulation of natural killer cell cytokine production" EXACT []
synonym: "up-regulation of natural killer cell cytokine production" EXACT []
synonym: "upregulation of natural killer cell cytokine production" EXACT []
is_a: GO:0002717 ! positive regulation of natural killer cell mediated immunity
is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response
is_a: GO:0002727 ! regulation of natural killer cell cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002370 ! natural killer cell cytokine production
relationship: positively_regulates GO:0002370 ! natural killer cell cytokine production

[Term]
id: GO:0002730
name: regulation of dendritic cell cytokine production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add]
is_a: GO:0002703 ! regulation of leukocyte mediated immunity
is_a: GO:0002718 ! regulation of cytokine production involved in immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002371 ! dendritic cell cytokine production
relationship: regulates GO:0002371 ! dendritic cell cytokine production

[Term]
id: GO:0002731
name: negative regulation of dendritic cell cytokine production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add]
synonym: "down regulation of dendritic cell cytokine production" EXACT []
synonym: "down-regulation of dendritic cell cytokine production" EXACT []
synonym: "downregulation of dendritic cell cytokine production" EXACT []
synonym: "inhibition of dendritic cell cytokine production" NARROW []
is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity
is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response
is_a: GO:0002730 ! regulation of dendritic cell cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002371 ! dendritic cell cytokine production
relationship: negatively_regulates GO:0002371 ! dendritic cell cytokine production

[Term]
id: GO:0002732
name: positive regulation of dendritic cell cytokine production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add]
synonym: "activation of dendritic cell cytokine production" NARROW []
synonym: "stimulation of dendritic cell cytokine production" NARROW []
synonym: "up regulation of dendritic cell cytokine production" EXACT []
synonym: "up-regulation of dendritic cell cytokine production" EXACT []
synonym: "upregulation of dendritic cell cytokine production" EXACT []
is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity
is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response
is_a: GO:0002730 ! regulation of dendritic cell cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002371 ! dendritic cell cytokine production
relationship: positively_regulates GO:0002371 ! dendritic cell cytokine production

[Term]
id: GO:0002733
name: regulation of myeloid dendritic cell cytokine production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add]
is_a: GO:0002730 ! regulation of dendritic cell cytokine production
is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002372 ! myeloid dendritic cell cytokine production
relationship: regulates GO:0002372 ! myeloid dendritic cell cytokine production

[Term]
id: GO:0002734
name: negative regulation of myeloid dendritic cell cytokine production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add]
synonym: "down regulation of myeloid dendritic cell cytokine production" EXACT []
synonym: "down-regulation of myeloid dendritic cell cytokine production" EXACT []
synonym: "downregulation of myeloid dendritic cell cytokine production" EXACT []
synonym: "inhibition of myeloid dendritic cell cytokine production" NARROW []
is_a: GO:0002731 ! negative regulation of dendritic cell cytokine production
is_a: GO:0002733 ! regulation of myeloid dendritic cell cytokine production
is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002372 ! myeloid dendritic cell cytokine production
relationship: negatively_regulates GO:0002372 ! myeloid dendritic cell cytokine production

[Term]
id: GO:0002735
name: positive regulation of myeloid dendritic cell cytokine production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add]
synonym: "activation of myeloid dendritic cell cytokine production" NARROW []
synonym: "stimulation of myeloid dendritic cell cytokine production" NARROW []
synonym: "up regulation of myeloid dendritic cell cytokine production" EXACT []
synonym: "up-regulation of myeloid dendritic cell cytokine production" EXACT []
synonym: "upregulation of myeloid dendritic cell cytokine production" EXACT []
is_a: GO:0002732 ! positive regulation of dendritic cell cytokine production
is_a: GO:0002733 ! regulation of myeloid dendritic cell cytokine production
is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity
is_a: GO:0061081 ! positive regulation of myeloid leukocyte cytokine production involved in immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002372 ! myeloid dendritic cell cytokine production
relationship: positively_regulates GO:0002372 ! myeloid dendritic cell cytokine production

[Term]
id: GO:0002736
name: regulation of plasmacytoid dendritic cell cytokine production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production." [GOC:add]
is_a: GO:0002730 ! regulation of dendritic cell cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002373 ! plasmacytoid dendritic cell cytokine production
relationship: regulates GO:0002373 ! plasmacytoid dendritic cell cytokine production

[Term]
id: GO:0002737
name: negative regulation of plasmacytoid dendritic cell cytokine production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production." [GOC:add]
synonym: "down regulation of plasmacytoid dendritic cell cytokine production" EXACT []
synonym: "down-regulation of plasmacytoid dendritic cell cytokine production" EXACT []
synonym: "downregulation of plasmacytoid dendritic cell cytokine production" EXACT []
synonym: "inhibition of plasmacytoid dendritic cell cytokine production" NARROW []
is_a: GO:0002731 ! negative regulation of dendritic cell cytokine production
is_a: GO:0002736 ! regulation of plasmacytoid dendritic cell cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002373 ! plasmacytoid dendritic cell cytokine production
relationship: negatively_regulates GO:0002373 ! plasmacytoid dendritic cell cytokine production

[Term]
id: GO:0002738
name: positive regulation of plasmacytoid dendritic cell cytokine production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production." [GOC:add]
synonym: "activation of plasmacytoid dendritic cell cytokine production" NARROW []
synonym: "stimulation of plasmacytoid dendritic cell cytokine production" NARROW []
synonym: "up regulation of plasmacytoid dendritic cell cytokine production" EXACT []
synonym: "up-regulation of plasmacytoid dendritic cell cytokine production" EXACT []
synonym: "upregulation of plasmacytoid dendritic cell cytokine production" EXACT []
is_a: GO:0002732 ! positive regulation of dendritic cell cytokine production
is_a: GO:0002736 ! regulation of plasmacytoid dendritic cell cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002373 ! plasmacytoid dendritic cell cytokine production
relationship: positively_regulates GO:0002373 ! plasmacytoid dendritic cell cytokine production

[Term]
id: GO:0002739
name: regulation of cytokine secretion involved in immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of cytokine secretion contributing to an immune response." [GOC:add]
synonym: "regulation of cytokine secretion during immune response" RELATED [GOC:dph]
is_a: GO:0002718 ! regulation of cytokine production involved in immune response
is_a: GO:0050707 ! regulation of cytokine secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002374 ! cytokine secretion involved in immune response
relationship: regulates GO:0002374 ! cytokine secretion involved in immune response

[Term]
id: GO:0002740
name: negative regulation of cytokine secretion involved in immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine secretion contributing to an immune response." [GOC:add]
synonym: "down regulation of cytokine secretion during immune response" RELATED []
synonym: "down-regulation of cytokine secretion during immune response" RELATED []
synonym: "downregulation of cytokine secretion during immune response" RELATED []
synonym: "inhibition of cytokine secretion during immune response" NARROW []
synonym: "negative regulation of cytokine secretion during immune response" RELATED [GOC:dph]
is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response
is_a: GO:0002739 ! regulation of cytokine secretion involved in immune response
is_a: GO:0050710 ! negative regulation of cytokine secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002374 ! cytokine secretion involved in immune response
relationship: negatively_regulates GO:0002374 ! cytokine secretion involved in immune response

[Term]
id: GO:0002741
name: positive regulation of cytokine secretion involved in immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of cytokine secretion contributing to an immune response." [GOC:add]
synonym: "activation of cytokine secretion during immune response" NARROW []
synonym: "positive regulation of cytokine secretion during immune response" RELATED [GOC:dph]
synonym: "stimulation of cytokine secretion during immune response" NARROW []
synonym: "up regulation of cytokine secretion during immune response" RELATED []
synonym: "up-regulation of cytokine secretion during immune response" RELATED []
synonym: "upregulation of cytokine secretion during immune response" RELATED []
is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response
is_a: GO:0002739 ! regulation of cytokine secretion involved in immune response
is_a: GO:0050715 ! positive regulation of cytokine secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002374 ! cytokine secretion involved in immune response
relationship: positively_regulates GO:0002374 ! cytokine secretion involved in immune response

[Term]
id: GO:0002742
name: regulation of cytokine biosynthetic process involved in immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of cytokine biosynthesis that contributes to an immune response." [GOC:add]
synonym: "regulation of cytokine biosynthetic process during immune response" RELATED [GOC:dph]
is_a: GO:0002718 ! regulation of cytokine production involved in immune response
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002375 ! cytokine biosynthetic process involved in immune response
relationship: regulates GO:0002375 ! cytokine biosynthetic process involved in immune response

[Term]
id: GO:0002743
name: negative regulation of cytokine biosynthetic process involved in immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine biosynthesis contributing to an immune response." [GOC:add]
synonym: "down regulation of cytokine biosynthetic process during immune response" RELATED []
synonym: "down-regulation of cytokine biosynthetic process during immune response" RELATED []
synonym: "downregulation of cytokine biosynthetic process during immune response" RELATED []
synonym: "inhibition of cytokine biosynthetic process during immune response" NARROW []
synonym: "negative regulation of cytokine biosynthetic process during immune response" RELATED [GOC:dph]
is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response
is_a: GO:0002742 ! regulation of cytokine biosynthetic process involved in immune response
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002375 ! cytokine biosynthetic process involved in immune response
relationship: negatively_regulates GO:0002375 ! cytokine biosynthetic process involved in immune response

[Term]
id: GO:0002744
name: positive regulation of cytokine biosynthetic process involved in immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of cytokine biosynthesis contributing to an immune response." [GOC:add]
synonym: "activation of cytokine biosynthetic process during immune response" NARROW []
synonym: "positive regulation of cytokine biosynthetic process during immune response" RELATED [GOC:dph]
synonym: "stimulation of cytokine biosynthetic process during immune response" NARROW []
synonym: "up regulation of cytokine biosynthetic process during immune response" RELATED []
synonym: "up-regulation of cytokine biosynthetic process during immune response" RELATED []
synonym: "upregulation of cytokine biosynthetic process during immune response" RELATED []
is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response
is_a: GO:0002742 ! regulation of cytokine biosynthetic process involved in immune response
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002375 ! cytokine biosynthetic process involved in immune response
relationship: positively_regulates GO:0002375 ! cytokine biosynthetic process involved in immune response

[Term]
id: GO:0002745
name: antigen processing and presentation initiated by receptor mediated uptake of antigen
namespace: biological_process
def: "Antigen processing and presentation which is initiated by uptake of antigen bound to a cell surface receptor." [GOC:add, ISBN:0781735149]
is_a: GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002746
name: antigen processing and presentation following pinocytosis
namespace: biological_process
def: "Antigen processing and presentation which is initiated by uptake of antigen via pinocytosis." [GOC:add, ISBN:0781735149]
is_a: GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002747
name: antigen processing and presentation following phagocytosis
namespace: biological_process
def: "Antigen processing and presentation which is initiated by uptake of antigen via phagocytosis." [GOC:add, ISBN:0781735149]
is_a: GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002748
name: antigen processing and presentation initiated by pattern recognition receptor mediated uptake of antigen
namespace: biological_process
def: "Antigen processing and presentation which is initiated by uptake of antigen bound to a cell surface pattern recognition receptor (PRR)." [GOC:add, ISBN:0781735149]
synonym: "antigen processing and presentation initiated by PAMP receptor mediated uptake of antigen" EXACT []
synonym: "antigen processing and presentation initiated by PRR mediated uptake of antigen" EXACT []
is_a: GO:0002745 ! antigen processing and presentation initiated by receptor mediated uptake of antigen

[Term]
id: GO:0002749
name: antigen processing and presentation initiated by toll-like receptor mediated phagocytosis of antigen
namespace: biological_process
def: "Antigen processing and presentation which is initiated by phagocytosis of antigen bound directly or indirectly to a cell surface toll-like receptor (TLR)." [GOC:add, ISBN:0781735149, PMID:15596122]
synonym: "antigen processing and presentation initiated by TLR mediated phagocytosis of antigen" EXACT []
is_a: GO:0002747 ! antigen processing and presentation following phagocytosis
is_a: GO:0002748 ! antigen processing and presentation initiated by pattern recognition receptor mediated uptake of antigen

[Term]
id: GO:0002750
name: antigen processing and presentation following macropinocytosis
namespace: biological_process
def: "Antigen processing and presentation which is initiated by uptake of antigen via macropinocytosis." [GOC:add, PMID:16556257]
is_a: GO:0002746 ! antigen processing and presentation following pinocytosis

[Term]
id: GO:0002751
name: antigen processing and presentation following receptor mediated endocytosis
namespace: biological_process
def: "Antigen processing and presentation which is initiated by uptake of antigen receptor-mediated endocytosis." [GOC:add, ISBN:0781735149]
is_a: GO:0002745 ! antigen processing and presentation initiated by receptor mediated uptake of antigen

[Term]
id: GO:0002752
name: cell surface pattern recognition receptor signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of a cell surface pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967]
synonym: "cell surface PAMP receptor signaling pathway" EXACT []
synonym: "cell surface pathogen receptor signaling pathway" EXACT []
synonym: "cell surface pattern recognition receptor signalling pathway" EXACT []
synonym: "cell surface PRR signaling pathway" EXACT []
is_a: GO:0002220 ! innate immune response activating cell surface receptor signaling pathway
is_a: GO:0002221 ! pattern recognition receptor signaling pathway

[Term]
id: GO:0002753
name: cytoplasmic pattern recognition receptor signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of a cytoplasmic pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967]
synonym: "cytoplasmic PAMP receptor signaling pathway" EXACT []
synonym: "cytoplasmic pathogen receptor signaling pathway" EXACT []
synonym: "cytoplasmic pattern recognition receptor signalling pathway" EXACT []
synonym: "cytoplasmic PRR signaling pathway" EXACT []
is_a: GO:0002221 ! pattern recognition receptor signaling pathway
is_a: GO:0030522 ! intracellular receptor signaling pathway
is_a: GO:0035556 ! intracellular signal transduction
intersection_of: GO:0002221 ! pattern recognition receptor signaling pathway
intersection_of: occurs_in GO:0005737 ! cytoplasm
relationship: occurs_in GO:0005737 ! cytoplasm

[Term]
id: GO:0002754
name: intracellular vesicle pattern recognition receptor signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of an intracellular vesicle pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967]
synonym: "intracellular vesicle PAMP receptor signaling pathway" EXACT []
synonym: "intracellular vesicle pathogen receptor signaling pathway" EXACT []
synonym: "intracellular vesicle pattern recognition receptor signalling pathway" EXACT []
synonym: "intracellular vesicle PRR signaling pathway" EXACT []
is_a: GO:0002221 ! pattern recognition receptor signaling pathway
is_a: GO:0030522 ! intracellular receptor signaling pathway

[Term]
id: GO:0002755
name: MyD88-dependent toll-like receptor signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response." [GOC:add, ISBN:0781735149, PMID:12467241, PMID:12524386, PMID:12855817, PMID:15585605, PMID:15728447]
synonym: "MyD88-dependent TLR signaling pathway" EXACT []
synonym: "MyD88-dependent toll-like receptor signalling pathway" EXACT []
xref: Reactome:REACT_100168 "MyD88 cascade initiated on plasma membrane, Gallus gallus"
xref: Reactome:REACT_101942 "MyD88:Mal cascade initiated on plasma membrane, Gallus gallus"
xref: Reactome:REACT_104035 "MyD88 cascade initiated on plasma membrane, Arabidopsis thaliana"
xref: Reactome:REACT_106952 "MyD88 cascade initiated on plasma membrane, Sus scrofa"
xref: Reactome:REACT_107977 "MyD88:Mal cascade initiated on plasma membrane, Xenopus tropicalis"
xref: Reactome:REACT_110031 "MyD88 cascade initiated on plasma membrane, Dictyostelium discoideum"
xref: Reactome:REACT_25089 "MyD88:TIRAP-dependent cascade initiated on plasma membrane, Gallus gallus"
xref: Reactome:REACT_27215 "MyD88 cascade initiated on plasma membrane, Homo sapiens"
xref: Reactome:REACT_27254 "MyD88-dependent cascade initiated on endosome membrane, Gallus gallus"
xref: Reactome:REACT_27259 "MyD88 cascade initiated on plasma membrane, Gallus gallus"
xref: Reactome:REACT_28050 "MyD88:Mal cascade initiated on plasma membrane, Danio rerio"
xref: Reactome:REACT_30270 "MyD88 cascade initiated on plasma membrane, Schizosaccharomyces pombe"
xref: Reactome:REACT_32510 "MyD88:Mal cascade initiated on plasma membrane, Caenorhabditis elegans"
xref: Reactome:REACT_34594 "MyD88:Mal cascade initiated on plasma membrane, Sus scrofa"
xref: Reactome:REACT_6788 "MyD88:Mal cascade initiated on plasma membrane, Homo sapiens"
xref: Reactome:REACT_79855 "MyD88:Mal cascade initiated on plasma membrane, Dictyostelium discoideum"
xref: Reactome:REACT_80624 "MyD88:Mal cascade initiated on plasma membrane, Arabidopsis thaliana"
xref: Reactome:REACT_80969 "MyD88:Mal cascade initiated on plasma membrane, Bos taurus"
xref: Reactome:REACT_81173 "MyD88 cascade initiated on plasma membrane, Mus musculus"
xref: Reactome:REACT_81183 "MyD88 cascade initiated on plasma membrane, Drosophila melanogaster"
xref: Reactome:REACT_85347 "MyD88:Mal cascade initiated on plasma membrane, Saccharomyces cerevisiae"
xref: Reactome:REACT_85793 "MyD88:Mal cascade initiated on plasma membrane, Taeniopygia guttata"
xref: Reactome:REACT_88707 "MyD88 cascade initiated on plasma membrane, Xenopus tropicalis"
xref: Reactome:REACT_88909 "MyD88 cascade initiated on plasma membrane, Caenorhabditis elegans"
xref: Reactome:REACT_90702 "MyD88:Mal cascade initiated on plasma membrane, Mus musculus"
xref: Reactome:REACT_92018 "MyD88:Mal cascade initiated on plasma membrane, Drosophila melanogaster"
xref: Reactome:REACT_92143 "MyD88:Mal cascade initiated on plasma membrane, Canis familiaris"
xref: Reactome:REACT_93524 "MyD88 cascade initiated on plasma membrane, Danio rerio"
xref: Reactome:REACT_93873 "MyD88 cascade initiated on plasma membrane, Saccharomyces cerevisiae"
xref: Reactome:REACT_95154 "MyD88 cascade initiated on plasma membrane, Bos taurus"
xref: Reactome:REACT_95427 "MyD88 cascade initiated on plasma membrane, Rattus norvegicus"
xref: Reactome:REACT_95678 "MyD88 cascade initiated on plasma membrane, Canis familiaris"
xref: Reactome:REACT_96158 "MyD88:Mal cascade initiated on plasma membrane, Rattus norvegicus"
xref: Reactome:REACT_96187 "MyD88 cascade initiated on plasma membrane, Taeniopygia guttata"
xref: Reactome:REACT_96209 "MyD88 cascade initiated on plasma membrane, Oryza sativa"
xref: Reactome:REACT_99530 "MyD88:Mal cascade initiated on plasma membrane, Oryza sativa"
xref: Reactome:REACT_99838 "MyD88:Mal cascade initiated on plasma membrane, Schizosaccharomyces pombe"
is_a: GO:0002224 ! toll-like receptor signaling pathway

[Term]
id: GO:0002756
name: MyD88-independent toll-like receptor signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor not relying on the MyD88 adaptor molecule. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response." [GOC:add, ISBN:0781735149, PMID:12467241, PMID:12524386, PMID:12855817, PMID:15585605, PMID:15728447]
synonym: "MyD88-independent TLR signaling pathway" EXACT []
synonym: "MyD88-independent toll-like receptor signalling pathway" EXACT []
xref: Reactome:REACT_100200 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, Gallus gallus"
xref: Reactome:REACT_102299 "MyD88-independent cascade initiated on plasma membrane, Caenorhabditis elegans"
xref: Reactome:REACT_102509 "TRAF6 Mediated Induction of proinflammatory cytokines, Dictyostelium discoideum"
xref: Reactome:REACT_102886 "TRAF6 Mediated Induction of proinflammatory cytokines, Saccharomyces cerevisiae"
xref: Reactome:REACT_104655 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Mus musculus"
xref: Reactome:REACT_105840 "TRAF6 Mediated Induction of proinflammatory cytokines, Gallus gallus"
xref: Reactome:REACT_105924 "TRAF6 Mediated Induction of proinflammatory cytokines, Mus musculus"
xref: Reactome:REACT_106037 "TRAF6 Mediated Induction of proinflammatory cytokines, Canis familiaris"
xref: Reactome:REACT_106039 "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, Mus musculus"
xref: Reactome:REACT_106964 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, Danio rerio"
xref: Reactome:REACT_109458 "TRAF6 Mediated Induction of proinflammatory cytokines, Rattus norvegicus"
xref: Reactome:REACT_110829 "MyD88-independent cascade initiated on plasma membrane, Canis familiaris"
xref: Reactome:REACT_110980 "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, Danio rerio"
xref: Reactome:REACT_114143 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Drosophila melanogaster"
xref: Reactome:REACT_25148 "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, Homo sapiens"
xref: Reactome:REACT_28259 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, Xenopus tropicalis"
xref: Reactome:REACT_28395 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, Bos taurus"
xref: Reactome:REACT_28410 "MyD88-independent cascade initiated on plasma membrane, Oryza sativa"
xref: Reactome:REACT_28525 "MyD88-independent cascade initiated on plasma membrane, Schizosaccharomyces pombe"
xref: Reactome:REACT_29826 "MyD88-independent cascade initiated on plasma membrane, Gallus gallus"
xref: Reactome:REACT_30390 "TRAF6 Mediated Induction of proinflammatory cytokines, Arabidopsis thaliana"
xref: Reactome:REACT_31920 "TRAF6 Mediated Induction of proinflammatory cytokines, Sus scrofa"
xref: Reactome:REACT_32587 "MyD88-independent cascade initiated on plasma membrane, Mus musculus"
xref: Reactome:REACT_32888 "MyD88-independent cascade initiated on plasma membrane, Sus scrofa"
xref: Reactome:REACT_33115 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Taeniopygia guttata"
xref: Reactome:REACT_33276 "MyD88-independent cascade initiated on plasma membrane, Danio rerio"
xref: Reactome:REACT_33454 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Sus scrofa"
xref: Reactome:REACT_33857 "TRAF6 Mediated Induction of proinflammatory cytokines, Oryza sativa"
xref: Reactome:REACT_34578 "TRAF6 Mediated Induction of proinflammatory cytokines, Drosophila melanogaster"
xref: Reactome:REACT_6782 "TRAF6 Mediated Induction of proinflammatory cytokines, Homo sapiens"
xref: Reactome:REACT_6809 "MyD88-independent cascade initiated on plasma membrane, Homo sapiens"
xref: Reactome:REACT_6898 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, Homo sapiens"
xref: Reactome:REACT_6976 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Homo sapiens"
xref: Reactome:REACT_70758 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Gallus gallus"
xref: Reactome:REACT_78892 "MyD88-independent cascade initiated on plasma membrane, Saccharomyces cerevisiae"
xref: Reactome:REACT_79777 "TRAF6 Mediated Induction of proinflammatory cytokines, Caenorhabditis elegans"
xref: Reactome:REACT_81045 "TRAF6 Mediated Induction of proinflammatory cytokines, Danio rerio"
xref: Reactome:REACT_81308 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Bos taurus"
xref: Reactome:REACT_81312 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, Sus scrofa"
xref: Reactome:REACT_82068 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Rattus norvegicus"
xref: Reactome:REACT_83083 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Canis familiaris"
xref: Reactome:REACT_85389 "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, Rattus norvegicus"
xref: Reactome:REACT_85560 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, Rattus norvegicus"
xref: Reactome:REACT_85813 "MyD88-independent cascade initiated on plasma membrane, Arabidopsis thaliana"
xref: Reactome:REACT_87120 "MyD88-independent cascade initiated on plasma membrane, Dictyostelium discoideum"
xref: Reactome:REACT_88311 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Xenopus tropicalis"
xref: Reactome:REACT_88396 "MyD88-independent cascade initiated on plasma membrane, Xenopus tropicalis"
xref: Reactome:REACT_88627 "TRAF6 Mediated Induction of proinflammatory cytokines, Schizosaccharomyces pombe"
xref: Reactome:REACT_89370 "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, Xenopus tropicalis"
xref: Reactome:REACT_89942 "MyD88-independent cascade initiated on plasma membrane, Rattus norvegicus"
xref: Reactome:REACT_90312 "TRAF6 Mediated Induction of proinflammatory cytokines, Bos taurus"
xref: Reactome:REACT_91487 "TRAF6 Mediated Induction of proinflammatory cytokines, Xenopus tropicalis"
xref: Reactome:REACT_91606 "MyD88-independent cascade initiated on plasma membrane, Taeniopygia guttata"
xref: Reactome:REACT_92796 "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, Taeniopygia guttata"
xref: Reactome:REACT_93657 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, Canis familiaris"
xref: Reactome:REACT_94894 "TRAF6 Mediated Induction of proinflammatory cytokines, Taeniopygia guttata"
xref: Reactome:REACT_95971 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, Taeniopygia guttata"
xref: Reactome:REACT_96392 "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, Bos taurus"
xref: Reactome:REACT_96482 "MyD88-independent cascade initiated on plasma membrane, Bos taurus"
xref: Reactome:REACT_97209 "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, Gallus gallus"
xref: Reactome:REACT_98583 "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, Sus scrofa"
xref: Reactome:REACT_99022 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Danio rerio"
xref: Reactome:REACT_99202 "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, Canis familiaris"
xref: Reactome:REACT_99347 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, Mus musculus"
xref: Reactome:REACT_99643 "MyD88-independent cascade initiated on plasma membrane, Drosophila melanogaster"
is_a: GO:0002224 ! toll-like receptor signaling pathway

[Term]
id: GO:0002757
name: immune response-activating signal transduction
namespace: biological_process
def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to activation or perpetuation of an immune response." [GOC:add]
is_a: GO:0002253 ! activation of immune response
is_a: GO:0002764 ! immune response-regulating signaling pathway

[Term]
id: GO:0002758
name: innate immune response-activating signal transduction
namespace: biological_process
def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to activation or perpetuation of an innate immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002218 ! activation of innate immune response
is_a: GO:0002757 ! immune response-activating signal transduction

[Term]
id: GO:0002759
name: regulation of antimicrobial humoral response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an antimicrobial humoral response." [GOC:add]
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0002920 ! regulation of humoral immune response
is_a: GO:0032101 ! regulation of response to external stimulus
is_a: GO:0043900 ! regulation of multi-organism process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019730 ! antimicrobial humoral response
relationship: regulates GO:0019730 ! antimicrobial humoral response

[Term]
id: GO:0002760
name: positive regulation of antimicrobial humoral response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of an antimicrobial humoral response." [GOC:add]
synonym: "activation of antimicrobial humoral response" NARROW []
synonym: "stimulation of antimicrobial humoral response" NARROW []
synonym: "up regulation of antimicrobial humoral response" EXACT []
synonym: "up-regulation of antimicrobial humoral response" EXACT []
synonym: "upregulation of antimicrobial humoral response" EXACT []
is_a: GO:0002759 ! regulation of antimicrobial humoral response
is_a: GO:0002833 ! positive regulation of response to biotic stimulus
is_a: GO:0002922 ! positive regulation of humoral immune response
is_a: GO:0032103 ! positive regulation of response to external stimulus
is_a: GO:0043902 ! positive regulation of multi-organism process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0019730 ! antimicrobial humoral response
relationship: positively_regulates GO:0019730 ! antimicrobial humoral response

[Term]
id: GO:0002761
name: regulation of myeloid leukocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add]
is_a: GO:0045637 ! regulation of myeloid cell differentiation
is_a: GO:1902105 ! regulation of leukocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002573 ! myeloid leukocyte differentiation
relationship: regulates GO:0002573 ! myeloid leukocyte differentiation

[Term]
id: GO:0002762
name: negative regulation of myeloid leukocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add]
synonym: "down regulation of myeloid leukocyte differentiation" EXACT []
synonym: "down-regulation of myeloid leukocyte differentiation" EXACT []
synonym: "downregulation of myeloid leukocyte differentiation" EXACT []
synonym: "inhibition of myeloid leukocyte differentiation" NARROW []
is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation
is_a: GO:0045638 ! negative regulation of myeloid cell differentiation
is_a: GO:1902106 ! negative regulation of leukocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002573 ! myeloid leukocyte differentiation
relationship: negatively_regulates GO:0002573 ! myeloid leukocyte differentiation

[Term]
id: GO:0002763
name: positive regulation of myeloid leukocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add]
synonym: "activation of myeloid leukocyte differentiation" NARROW []
synonym: "stimulation of myeloid leukocyte differentiation" NARROW []
synonym: "up regulation of myeloid leukocyte differentiation" EXACT []
synonym: "up-regulation of myeloid leukocyte differentiation" EXACT []
synonym: "upregulation of myeloid leukocyte differentiation" EXACT []
is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation
is_a: GO:0045639 ! positive regulation of myeloid cell differentiation
is_a: GO:1902107 ! positive regulation of leukocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002573 ! myeloid leukocyte differentiation
relationship: positively_regulates GO:0002573 ! myeloid leukocyte differentiation

[Term]
id: GO:0002764
name: immune response-regulating signaling pathway
namespace: biological_process
def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to the activation, perpetuation, or inhibition of an immune response." [GOC:add, ISBN:0781735149, PMID:15771571]
synonym: "immune response-regulating signalling pathway" EXACT [GOC:mah]
is_a: GO:0007165 ! signal transduction
is_a: GO:0050776 ! regulation of immune response

[Term]
id: GO:0002765
name: immune response-inhibiting signal transduction
namespace: biological_process
def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to inhibition of an immune response." [GOC:add, ISBN:0781735149]
is_a: GO:0002764 ! immune response-regulating signaling pathway

[Term]
id: GO:0002766
name: innate immune response-inhibiting signal transduction
namespace: biological_process
def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to inhibition of an innate immune response." [GOC:add, ISBN:0781735149, PMID:15771571]
is_a: GO:0002765 ! immune response-inhibiting signal transduction

[Term]
id: GO:0002767
name: immune response-inhibiting cell surface receptor signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of inhibiting an immune response." [GOC:add, ISBN:0781735149, PMID:15771571]
synonym: "immune response-inhibiting cell surface receptor signalling pathway" EXACT []
is_a: GO:0002765 ! immune response-inhibiting signal transduction
is_a: GO:0002768 ! immune response-regulating cell surface receptor signaling pathway

[Term]
id: GO:0002768
name: immune response-regulating cell surface receptor signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of activating, perpetuating, or inhibiting an immune response." [GOC:add, ISBN:0781735149, PMID:15771571]
synonym: "immune response-regulating cell surface receptor signalling pathway" EXACT []
is_a: GO:0002764 ! immune response-regulating signaling pathway
is_a: GO:0007166 ! cell surface receptor signaling pathway

[Term]
id: GO:0002769
name: natural killer cell inhibitory signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a natural killer cell capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, ISBN:0781735149, PMID:15771571]
synonym: "inhibitory KIR signaling pathway" NARROW []
synonym: "killer cell inhibitory receptor signaling pathway" NARROW []
synonym: "Ly49 inhibitory receptor signaling pathway" RELATED []
synonym: "natural killer cell inhibitory signalling pathway" EXACT []
synonym: "NK cell inhibitory signaling pathway" EXACT []
is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway

[Term]
id: GO:0002770
name: T cell inhibitory signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a T cell capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, PMID:15258309]
synonym: "T cell inhibitory signalling pathway" EXACT []
synonym: "T lymphocyte inhibitory signaling pathway" EXACT []
synonym: "T-cell inhibitory signaling pathway" EXACT []
synonym: "T-lymphocyte inhibitory signaling pathway" EXACT []
is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway

[Term]
id: GO:0002771
name: inhibitory killer cell immunoglobulin-like receptor signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of an extracellular ligand to a inhibitory killer cell immunoglobulin-like receptor capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, ISBN:0781735149, PMID:15771571]
synonym: "inhibitory killer cell immunoglobulin-like receptor signalling pathway" EXACT []
synonym: "killer cell inhibitory receptor signaling pathway" EXACT []
synonym: "KIR signaling pathway" EXACT []
is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway

[Term]
id: GO:0002772
name: inhibitory C-type lectin receptor signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of an extracellular ligand to an inhibitory C-type lectin receptor capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, ISBN:0781735149, PMID:15771571]
synonym: "inhibitory C-type lectin receptor signalling pathway" EXACT []
synonym: "Ly49 inhibitory receptor signaling pathway" RELATED []
is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway

[Term]
id: GO:0002773
name: B cell inhibitory signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a B cell capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, PMID:16413920]
synonym: "B cell inhibitory signalling pathway" EXACT []
synonym: "B lymphocyte inhibitory signaling pathwayBT-lymphocyte inhibitory signaling pathway" EXACT []
synonym: "B-cell inhibitory signaling pathway" EXACT []
is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway

[Term]
id: GO:0002774
name: Fc receptor mediated inhibitory signaling pathway
namespace: biological_process
def: "A series of molecular signals generated as a consequence of the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of inhibiting an immune effector process contributing to an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region." [GOC:add, ISBN:0781735149]
synonym: "Fc receptor mediated inhibitory signalling pathway" EXACT []
synonym: "Fc-receptor mediated inhibitory signaling pathway" EXACT []
is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway

[Term]
id: GO:0002775
name: antimicrobial peptide production
namespace: biological_process
def: "The synthesis or release of an antimicrobial peptide during an immune response, resulting in an increase in intracellular or extracellular levels. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]
is_a: GO:0002440 ! production of molecular mediator of immune response
relationship: part_of GO:0019730 ! antimicrobial humoral response

[Term]
id: GO:0002776
name: antimicrobial peptide secretion
namespace: biological_process
def: "The regulated release of an antimicrobial peptide from a cell or a tissue. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]
is_a: GO:0002790 ! peptide secretion
relationship: part_of GO:0002775 ! antimicrobial peptide production

[Term]
id: GO:0002777
name: antimicrobial peptide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an antimicrobial peptide. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]
is_a: GO:0043043 ! peptide biosynthetic process
relationship: part_of GO:0002775 ! antimicrobial peptide production

[Term]
id: GO:0002778
name: antibacterial peptide production
namespace: biological_process
def: "The synthesis or release of an antibacterial peptide during an immune response, resulting in an increase in intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]
is_a: GO:0002775 ! antimicrobial peptide production
relationship: part_of GO:0019731 ! antibacterial humoral response

[Term]
id: GO:0002779
name: antibacterial peptide secretion
namespace: biological_process
def: "The regulated release of an antibacterial peptide from a cell or a tissue." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]
is_a: GO:0002776 ! antimicrobial peptide secretion
relationship: part_of GO:0002778 ! antibacterial peptide production

[Term]
id: GO:0002780
name: antibacterial peptide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an antibacterial peptide." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]
is_a: GO:0002777 ! antimicrobial peptide biosynthetic process
relationship: part_of GO:0002778 ! antibacterial peptide production

[Term]
id: GO:0002781
name: antifungal peptide production
namespace: biological_process
def: "The synthesis or release of an antifungal peptide during an immune response, resulting in an increase in intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]
is_a: GO:0002775 ! antimicrobial peptide production
relationship: part_of GO:0019732 ! antifungal humoral response

[Term]
id: GO:0002782
name: antifungal peptide secretion
namespace: biological_process
def: "The regulated release of an antifungal peptide from a cell or a tissue." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]
is_a: GO:0002776 ! antimicrobial peptide secretion
relationship: part_of GO:0002781 ! antifungal peptide production

[Term]
id: GO:0002783
name: antifungal peptide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an antifungal peptide." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]
is_a: GO:0002777 ! antimicrobial peptide biosynthetic process
relationship: part_of GO:0002781 ! antifungal peptide production

[Term]
id: GO:0002784
name: regulation of antimicrobial peptide production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antimicrobial peptide production." [GOC:add]
is_a: GO:0002700 ! regulation of production of molecular mediator of immune response
is_a: GO:0002759 ! regulation of antimicrobial humoral response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002775 ! antimicrobial peptide production
relationship: regulates GO:0002775 ! antimicrobial peptide production

[Term]
id: GO:0002785
name: negative regulation of antimicrobial peptide production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide production." [GOC:add]
synonym: "down regulation of antimicrobial peptide production" EXACT []
synonym: "down-regulation of antimicrobial peptide production" EXACT []
synonym: "downregulation of antimicrobial peptide production" EXACT []
synonym: "inhibition of antimicrobial peptide production" NARROW []
is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response
is_a: GO:0002784 ! regulation of antimicrobial peptide production
is_a: GO:0008348 ! negative regulation of antimicrobial humoral response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002775 ! antimicrobial peptide production
relationship: negatively_regulates GO:0002775 ! antimicrobial peptide production

[Term]
id: GO:0002786
name: regulation of antibacterial peptide production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antibacterial peptide production." [GOC:add]
is_a: GO:0002784 ! regulation of antimicrobial peptide production
is_a: GO:1900424 ! regulation of defense response to bacterium
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002778 ! antibacterial peptide production
relationship: regulates GO:0002778 ! antibacterial peptide production

[Term]
id: GO:0002787
name: negative regulation of antibacterial peptide production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide production." [GOC:add]
synonym: "down regulation of antibacterial peptide production" EXACT []
synonym: "down-regulation of antibacterial peptide production" EXACT []
synonym: "downregulation of antibacterial peptide production" EXACT []
synonym: "inhibition of antibacterial peptide production" NARROW []
is_a: GO:0002785 ! negative regulation of antimicrobial peptide production
is_a: GO:0002786 ! regulation of antibacterial peptide production
is_a: GO:1900425 ! negative regulation of defense response to bacterium
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002778 ! antibacterial peptide production
relationship: negatively_regulates GO:0002778 ! antibacterial peptide production

[Term]
id: GO:0002788
name: regulation of antifungal peptide production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antifungal peptide production." [GOC:add]
is_a: GO:0002784 ! regulation of antimicrobial peptide production
is_a: GO:1900150 ! regulation of defense response to fungus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002781 ! antifungal peptide production
relationship: regulates GO:0002781 ! antifungal peptide production

[Term]
id: GO:0002789
name: negative regulation of antifungal peptide production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide production." [GOC:add]
synonym: "down regulation of antifungal peptide production" EXACT []
synonym: "down-regulation of antifungal peptide production" EXACT []
synonym: "downregulation of antifungal peptide production" EXACT []
synonym: "inhibition of antifungal peptide production" NARROW []
is_a: GO:0002785 ! negative regulation of antimicrobial peptide production
is_a: GO:0002788 ! regulation of antifungal peptide production
is_a: GO:0031348 ! negative regulation of defense response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002781 ! antifungal peptide production
relationship: negatively_regulates GO:0002781 ! antifungal peptide production

[Term]
id: GO:0002790
name: peptide secretion
namespace: biological_process
def: "The controlled release of a peptide from a cell or a tissue." [GOC:add]
is_a: GO:0015833 ! peptide transport
is_a: GO:0046903 ! secretion

[Term]
id: GO:0002791
name: regulation of peptide secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of peptide secretion." [GOC:add]
is_a: GO:0051046 ! regulation of secretion
is_a: GO:0090087 ! regulation of peptide transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002790 ! peptide secretion
relationship: regulates GO:0002790 ! peptide secretion

[Term]
id: GO:0002792
name: negative regulation of peptide secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion." [GOC:add]
synonym: "down regulation of peptide secretion" EXACT []
synonym: "down-regulation of peptide secretion" EXACT []
synonym: "downregulation of peptide secretion" EXACT []
synonym: "inhibition of peptide secretion" NARROW []
is_a: GO:0002791 ! regulation of peptide secretion
is_a: GO:0051048 ! negative regulation of secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002790 ! peptide secretion
relationship: negatively_regulates GO:0002790 ! peptide secretion

[Term]
id: GO:0002793
name: positive regulation of peptide secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of peptide secretion." [GOC:add]
synonym: "activation of peptide secretion" NARROW []
synonym: "stimulation of peptide secretion" NARROW []
synonym: "up regulation of peptide secretion" EXACT []
synonym: "up-regulation of peptide secretion" EXACT []
synonym: "upregulation of peptide secretion" EXACT []
is_a: GO:0002791 ! regulation of peptide secretion
is_a: GO:0051047 ! positive regulation of secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002790 ! peptide secretion
relationship: positively_regulates GO:0002790 ! peptide secretion

[Term]
id: GO:0002794
name: regulation of antimicrobial peptide secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antimicrobial peptide secretion." [GOC:add]
is_a: GO:0002784 ! regulation of antimicrobial peptide production
is_a: GO:0002791 ! regulation of peptide secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002776 ! antimicrobial peptide secretion
relationship: regulates GO:0002776 ! antimicrobial peptide secretion

[Term]
id: GO:0002795
name: negative regulation of antimicrobial peptide secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide secretion." [GOC:add]
synonym: "down regulation of antimicrobial peptide secretion" EXACT []
synonym: "down-regulation of antimicrobial peptide secretion" EXACT []
synonym: "downregulation of antimicrobial peptide secretion" EXACT []
synonym: "inhibition of antimicrobial peptide secretion" NARROW []
is_a: GO:0002785 ! negative regulation of antimicrobial peptide production
is_a: GO:0002792 ! negative regulation of peptide secretion
is_a: GO:0002794 ! regulation of antimicrobial peptide secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002776 ! antimicrobial peptide secretion
relationship: negatively_regulates GO:0002776 ! antimicrobial peptide secretion

[Term]
id: GO:0002796
name: positive regulation of antimicrobial peptide secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide secretion." [GOC:add]
synonym: "activation of antimicrobial peptide secretion" NARROW []
synonym: "stimulation of antimicrobial peptide secretion" NARROW []
synonym: "up regulation of antimicrobial peptide secretion" EXACT []
synonym: "up-regulation of antimicrobial peptide secretion" EXACT []
synonym: "upregulation of antimicrobial peptide secretion" EXACT []
is_a: GO:0002225 ! positive regulation of antimicrobial peptide production
is_a: GO:0002793 ! positive regulation of peptide secretion
is_a: GO:0002794 ! regulation of antimicrobial peptide secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002776 ! antimicrobial peptide secretion
relationship: positively_regulates GO:0002776 ! antimicrobial peptide secretion

[Term]
id: GO:0002797
name: regulation of antibacterial peptide secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antibacterial peptide secretion." [GOC:add]
is_a: GO:0002786 ! regulation of antibacterial peptide production
is_a: GO:0002794 ! regulation of antimicrobial peptide secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002779 ! antibacterial peptide secretion
relationship: regulates GO:0002779 ! antibacterial peptide secretion

[Term]
id: GO:0002798
name: negative regulation of antibacterial peptide secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide secretion." [GOC:add]
synonym: "down regulation of antibacterial peptide secretion" EXACT []
synonym: "down-regulation of antibacterial peptide secretion" EXACT []
synonym: "downregulation of antibacterial peptide secretion" EXACT []
synonym: "inhibition of antibacterial peptide secretion" NARROW []
is_a: GO:0002787 ! negative regulation of antibacterial peptide production
is_a: GO:0002795 ! negative regulation of antimicrobial peptide secretion
is_a: GO:0002797 ! regulation of antibacterial peptide secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002779 ! antibacterial peptide secretion
relationship: negatively_regulates GO:0002779 ! antibacterial peptide secretion

[Term]
id: GO:0002799
name: positive regulation of antibacterial peptide secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antibacterial peptide secretion." [GOC:add]
synonym: "activation of antibacterial peptide secretion" NARROW []
synonym: "stimulation of antibacterial peptide secretion" NARROW []
synonym: "up regulation of antibacterial peptide secretion" EXACT []
synonym: "up-regulation of antibacterial peptide secretion" EXACT []
synonym: "upregulation of antibacterial peptide secretion" EXACT []
is_a: GO:0002796 ! positive regulation of antimicrobial peptide secretion
is_a: GO:0002797 ! regulation of antibacterial peptide secretion
is_a: GO:0002803 ! positive regulation of antibacterial peptide production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002779 ! antibacterial peptide secretion
relationship: positively_regulates GO:0002779 ! antibacterial peptide secretion

[Term]
id: GO:0002800
name: regulation of antifungal peptide secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antifungal peptide secretion." [GOC:add]
is_a: GO:0002788 ! regulation of antifungal peptide production
is_a: GO:0002794 ! regulation of antimicrobial peptide secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002782 ! antifungal peptide secretion
relationship: regulates GO:0002782 ! antifungal peptide secretion

[Term]
id: GO:0002801
name: negative regulation of antifungal peptide secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide secretion." [GOC:add]
synonym: "down regulation of antifungal peptide secretion" EXACT []
synonym: "down-regulation of antifungal peptide secretion" EXACT []
synonym: "downregulation of antifungal peptide secretion" EXACT []
synonym: "inhibition of antifungal peptide secretion" NARROW []
is_a: GO:0002789 ! negative regulation of antifungal peptide production
is_a: GO:0002795 ! negative regulation of antimicrobial peptide secretion
is_a: GO:0002800 ! regulation of antifungal peptide secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002782 ! antifungal peptide secretion
relationship: negatively_regulates GO:0002782 ! antifungal peptide secretion

[Term]
id: GO:0002802
name: positive regulation of antifungal peptide secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antifungal peptide secretion." [GOC:add]
synonym: "activation of antifungal peptide secretion" NARROW []
synonym: "stimulation of antifungal peptide secretion" NARROW []
synonym: "up regulation of antifungal peptide secretion" EXACT []
synonym: "up-regulation of antifungal peptide secretion" EXACT []
synonym: "upregulation of antifungal peptide secretion" EXACT []
is_a: GO:0002796 ! positive regulation of antimicrobial peptide secretion
is_a: GO:0002800 ! regulation of antifungal peptide secretion
is_a: GO:0002804 ! positive regulation of antifungal peptide production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002782 ! antifungal peptide secretion
relationship: positively_regulates GO:0002782 ! antifungal peptide secretion

[Term]
id: GO:0002803
name: positive regulation of antibacterial peptide production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antibacterial peptide production." [GOC:add]
synonym: "activation of antibacterial peptide production" NARROW []
synonym: "stimulation of antibacterial peptide production" NARROW []
synonym: "up regulation of antibacterial peptide production" EXACT []
synonym: "up-regulation of antibacterial peptide production" EXACT []
synonym: "upregulation of antibacterial peptide production" EXACT []
is_a: GO:0002225 ! positive regulation of antimicrobial peptide production
is_a: GO:0002786 ! regulation of antibacterial peptide production
is_a: GO:1900426 ! positive regulation of defense response to bacterium
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002778 ! antibacterial peptide production
relationship: positively_regulates GO:0002778 ! antibacterial peptide production

[Term]
id: GO:0002804
name: positive regulation of antifungal peptide production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antifungal peptide production." [GOC:add]
synonym: "activation of antifungal peptide production" NARROW []
synonym: "stimulation of antifungal peptide production" NARROW []
synonym: "up regulation of antifungal peptide production" EXACT []
synonym: "up-regulation of antifungal peptide production" EXACT []
synonym: "upregulation of antifungal peptide production" EXACT []
is_a: GO:0002225 ! positive regulation of antimicrobial peptide production
is_a: GO:0002788 ! regulation of antifungal peptide production
is_a: GO:0031349 ! positive regulation of defense response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002781 ! antifungal peptide production
relationship: positively_regulates GO:0002781 ! antifungal peptide production

[Term]
id: GO:0002805
name: regulation of antimicrobial peptide biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antimicrobial peptide biosynthesis." [GOC:add]
is_a: GO:0002784 ! regulation of antimicrobial peptide production
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0034248 ! regulation of cellular amide metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002777 ! antimicrobial peptide biosynthetic process
relationship: regulates GO:0002777 ! antimicrobial peptide biosynthetic process

[Term]
id: GO:0002806
name: negative regulation of antimicrobial peptide biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide biosynthesis." [GOC:add]
synonym: "down regulation of antimicrobial peptide biosynthetic process" EXACT []
synonym: "down-regulation of antimicrobial peptide biosynthetic process" EXACT []
synonym: "downregulation of antimicrobial peptide biosynthetic process" EXACT []
synonym: "inhibition of antimicrobial peptide biosynthetic process" NARROW []
is_a: GO:0002785 ! negative regulation of antimicrobial peptide production
is_a: GO:0002805 ! regulation of antimicrobial peptide biosynthetic process
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0034249 ! negative regulation of cellular amide metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002777 ! antimicrobial peptide biosynthetic process
relationship: negatively_regulates GO:0002777 ! antimicrobial peptide biosynthetic process

[Term]
id: GO:0002807
name: positive regulation of antimicrobial peptide biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide biosynthesis." [GOC:add]
synonym: "activation of antimicrobial peptide biosynthetic process" NARROW []
synonym: "stimulation of antimicrobial peptide biosynthetic process" NARROW []
synonym: "up regulation of antimicrobial peptide biosynthetic process" EXACT []
synonym: "up-regulation of antimicrobial peptide biosynthetic process" EXACT []
synonym: "upregulation of antimicrobial peptide biosynthetic process" EXACT []
is_a: GO:0002225 ! positive regulation of antimicrobial peptide production
is_a: GO:0002805 ! regulation of antimicrobial peptide biosynthetic process
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0034250 ! positive regulation of cellular amide metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002777 ! antimicrobial peptide biosynthetic process
relationship: positively_regulates GO:0002777 ! antimicrobial peptide biosynthetic process

[Term]
id: GO:0002808
name: regulation of antibacterial peptide biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antibacterial peptide biosynthesis." [GOC:add]
is_a: GO:0002786 ! regulation of antibacterial peptide production
is_a: GO:0002805 ! regulation of antimicrobial peptide biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002780 ! antibacterial peptide biosynthetic process
relationship: regulates GO:0002780 ! antibacterial peptide biosynthetic process

[Term]
id: GO:0002809
name: negative regulation of antibacterial peptide biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide biosynthesis." [GOC:add]
synonym: "down regulation of antibacterial peptide biosynthetic process" EXACT []
synonym: "down-regulation of antibacterial peptide biosynthetic process" EXACT []
synonym: "downregulation of antibacterial peptide biosynthetic process" EXACT []
synonym: "inhibition of antibacterial peptide biosynthetic process" NARROW []
is_a: GO:0002787 ! negative regulation of antibacterial peptide production
is_a: GO:0002806 ! negative regulation of antimicrobial peptide biosynthetic process
is_a: GO:0002808 ! regulation of antibacterial peptide biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002780 ! antibacterial peptide biosynthetic process
relationship: negatively_regulates GO:0002780 ! antibacterial peptide biosynthetic process

[Term]
id: GO:0002810
name: regulation of antifungal peptide biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antifungal peptide biosynthesis." [GOC:add]
is_a: GO:0002788 ! regulation of antifungal peptide production
is_a: GO:0002805 ! regulation of antimicrobial peptide biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002783 ! antifungal peptide biosynthetic process
relationship: regulates GO:0002783 ! antifungal peptide biosynthetic process

[Term]
id: GO:0002811
name: negative regulation of antifungal peptide biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide biosynthesis." [GOC:add]
synonym: "down regulation of antifungal peptide biosynthetic process" EXACT []
synonym: "down-regulation of antifungal peptide biosynthetic process" EXACT []
synonym: "downregulation of antifungal peptide biosynthetic process" EXACT []
synonym: "inhibition of antifungal peptide biosynthetic process" NARROW []
is_a: GO:0002789 ! negative regulation of antifungal peptide production
is_a: GO:0002806 ! negative regulation of antimicrobial peptide biosynthetic process
is_a: GO:0002810 ! regulation of antifungal peptide biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002783 ! antifungal peptide biosynthetic process
relationship: negatively_regulates GO:0002783 ! antifungal peptide biosynthetic process

[Term]
id: GO:0002812
name: biosynthetic process of antibacterial peptides active against Gram-negative bacteria
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an antibacterial peptide with activity against Gram-negative bacteria." [GOC:add, PMID:11807545]
is_a: GO:0002780 ! antibacterial peptide biosynthetic process
relationship: part_of GO:0050829 ! defense response to Gram-negative bacterium

[Term]
id: GO:0002813
name: regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria." [GOC:add]
is_a: GO:0002808 ! regulation of antibacterial peptide biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002812 ! biosynthetic process of antibacterial peptides active against Gram-negative bacteria
relationship: regulates GO:0002812 ! biosynthetic process of antibacterial peptides active against Gram-negative bacteria

[Term]
id: GO:0002814
name: negative regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria." [GOC:add]
synonym: "down regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT []
synonym: "down-regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT []
synonym: "downregulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT []
synonym: "inhibition of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" NARROW []
is_a: GO:0002809 ! negative regulation of antibacterial peptide biosynthetic process
is_a: GO:0002813 ! regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002812 ! biosynthetic process of antibacterial peptides active against Gram-negative bacteria
relationship: negatively_regulates GO:0002812 ! biosynthetic process of antibacterial peptides active against Gram-negative bacteria

[Term]
id: GO:0002815
name: biosynthetic process of antibacterial peptides active against Gram-positive bacteria
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an antibacterial peptide with activity against Gram-positive bacteria." [GOC:add]
is_a: GO:0002780 ! antibacterial peptide biosynthetic process
relationship: part_of GO:0050830 ! defense response to Gram-positive bacterium

[Term]
id: GO:0002816
name: regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria." [GOC:add]
is_a: GO:0002808 ! regulation of antibacterial peptide biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002815 ! biosynthetic process of antibacterial peptides active against Gram-positive bacteria
relationship: regulates GO:0002815 ! biosynthetic process of antibacterial peptides active against Gram-positive bacteria

[Term]
id: GO:0002817
name: negative regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria." [GOC:add]
synonym: "down regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT []
synonym: "down-regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT []
synonym: "downregulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT []
synonym: "inhibition of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" NARROW []
is_a: GO:0002809 ! negative regulation of antibacterial peptide biosynthetic process
is_a: GO:0002816 ! regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002815 ! biosynthetic process of antibacterial peptides active against Gram-positive bacteria
relationship: negatively_regulates GO:0002815 ! biosynthetic process of antibacterial peptides active against Gram-positive bacteria

[Term]
id: GO:0002818
name: intracellular defense response
namespace: biological_process
def: "A physiological defense response which occurs intracellularly." [GOC:add]
synonym: "intracellular defence response" EXACT []
is_a: GO:0006968 ! cellular defense response
is_a: GO:0033554 ! cellular response to stress
intersection_of: GO:0006952 ! defense response
intersection_of: occurs_in GO:0005622 ! intracellular
relationship: occurs_in GO:0005622 ! intracellular

[Term]
id: GO:0002819
name: regulation of adaptive immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an adaptive immune response." [GOC:add]
is_a: GO:0050776 ! regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002250 ! adaptive immune response
relationship: regulates GO:0002250 ! adaptive immune response

[Term]
id: GO:0002820
name: negative regulation of adaptive immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response." [GOC:add]
synonym: "down regulation of adaptive immune response" EXACT []
synonym: "down-regulation of adaptive immune response" EXACT []
synonym: "downregulation of adaptive immune response" EXACT []
synonym: "inhibition of adaptive immune response" NARROW []
is_a: GO:0002819 ! regulation of adaptive immune response
is_a: GO:0050777 ! negative regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002250 ! adaptive immune response
relationship: negatively_regulates GO:0002250 ! adaptive immune response

[Term]
id: GO:0002821
name: positive regulation of adaptive immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response." [GOC:add]
synonym: "activation of adaptive immune response" NARROW []
synonym: "stimulation of adaptive immune response" NARROW []
synonym: "up regulation of adaptive immune response" EXACT []
synonym: "up-regulation of adaptive immune response" EXACT []
synonym: "upregulation of adaptive immune response" EXACT []
is_a: GO:0002819 ! regulation of adaptive immune response
is_a: GO:0050778 ! positive regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002250 ! adaptive immune response
relationship: positively_regulates GO:0002250 ! adaptive immune response

[Term]
id: GO:0002822
name: regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu]
is_a: GO:0002819 ! regulation of adaptive immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
relationship: regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

[Term]
id: GO:0002823
name: negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu]
is_a: GO:0002820 ! negative regulation of adaptive immune response
is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
relationship: negatively_regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

[Term]
id: GO:0002824
name: positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu]
is_a: GO:0002821 ! positive regulation of adaptive immune response
is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
relationship: positively_regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

[Term]
id: GO:0002825
name: regulation of T-helper 1 type immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a T-helper 1 type immune response." [GOC:add]
is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042088 ! T-helper 1 type immune response
relationship: regulates GO:0042088 ! T-helper 1 type immune response

[Term]
id: GO:0002826
name: negative regulation of T-helper 1 type immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a T-helper 1 type immune response." [GOC:add]
synonym: "down regulation of T-helper 1 type immune response" EXACT []
synonym: "down-regulation of T-helper 1 type immune response" EXACT []
synonym: "downregulation of T-helper 1 type immune response" EXACT []
synonym: "inhibition of T-helper 1 type immune response" NARROW []
is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
is_a: GO:0002825 ! regulation of T-helper 1 type immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042088 ! T-helper 1 type immune response
relationship: negatively_regulates GO:0042088 ! T-helper 1 type immune response

[Term]
id: GO:0002827
name: positive regulation of T-helper 1 type immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of a T-helper 1 type immune response." [GOC:add]
synonym: "activation of T-helper 1 type immune response" NARROW []
synonym: "stimulation of T-helper 1 type immune response" NARROW []
synonym: "up regulation of T-helper 1 type immune response" EXACT []
synonym: "up-regulation of T-helper 1 type immune response" EXACT []
synonym: "upregulation of T-helper 1 type immune response" EXACT []
is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
is_a: GO:0002825 ! regulation of T-helper 1 type immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042088 ! T-helper 1 type immune response
relationship: positively_regulates GO:0042088 ! T-helper 1 type immune response

[Term]
id: GO:0002828
name: regulation of type 2 immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a type 2 immune response." [GOC:add]
synonym: "regulation of T-helper 2 type immune response" NARROW [GOC:add]
synonym: "regulation of Th2 immune response" NARROW [GOC:add]
is_a: GO:0050776 ! regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042092 ! type 2 immune response
relationship: regulates GO:0042092 ! type 2 immune response

[Term]
id: GO:0002829
name: negative regulation of type 2 immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a type 2 immune response." [GOC:add]
synonym: "down regulation of type 2 immune response" EXACT []
synonym: "down-regulation of type 2 immune response" EXACT []
synonym: "downregulation of type 2 immune response" EXACT []
synonym: "inhibition of type 2 immune response" NARROW []
synonym: "negative regulation of T-helper 2 type immune response" NARROW [GOC:add]
synonym: "negative regulation of Th2 immune response" NARROW [GOC:add]
is_a: GO:0002828 ! regulation of type 2 immune response
is_a: GO:0050777 ! negative regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042092 ! type 2 immune response
relationship: negatively_regulates GO:0042092 ! type 2 immune response

[Term]
id: GO:0002830
name: positive regulation of type 2 immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of a type 2 immune response." [GOC:add]
synonym: "activation of type 2 immune response" NARROW []
synonym: "positive regulation of T-helper 2 type immune response" NARROW [GOC:add]
synonym: "positive regulation of Th2 immune response" NARROW [GOC:add]
synonym: "stimulation of type 2 immune response" NARROW []
synonym: "up regulation of type 2 immune response" EXACT []
synonym: "up-regulation of type 2 immune response" EXACT []
synonym: "upregulation of type 2 immune response" EXACT []
is_a: GO:0002828 ! regulation of type 2 immune response
is_a: GO:0050778 ! positive regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042092 ! type 2 immune response
relationship: positively_regulates GO:0042092 ! type 2 immune response

[Term]
id: GO:0002831
name: regulation of response to biotic stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a response to biotic stimulus." [GOC:add]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
is_a: GO:0048583 ! regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009607 ! response to biotic stimulus
relationship: regulates GO:0009607 ! response to biotic stimulus

[Term]
id: GO:0002832
name: negative regulation of response to biotic stimulus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus." [GOC:add]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
synonym: "down regulation of response to biotic stimulus" EXACT []
synonym: "down-regulation of response to biotic stimulus" EXACT []
synonym: "downregulation of response to biotic stimulus" EXACT []
synonym: "inhibition of response to biotic stimulus" NARROW []
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0048585 ! negative regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009607 ! response to biotic stimulus
relationship: negatively_regulates GO:0009607 ! response to biotic stimulus

[Term]
id: GO:0002833
name: positive regulation of response to biotic stimulus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus." [GOC:add]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
synonym: "activation of response to biotic stimulus" NARROW []
synonym: "stimulation of response to biotic stimulus" NARROW []
synonym: "up regulation of response to biotic stimulus" EXACT []
synonym: "up-regulation of response to biotic stimulus" EXACT []
synonym: "upregulation of response to biotic stimulus" EXACT []
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0048584 ! positive regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009607 ! response to biotic stimulus
relationship: positively_regulates GO:0009607 ! response to biotic stimulus

[Term]
id: GO:0002834
name: regulation of response to tumor cell
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a response to tumor cell." [GOC:add]
synonym: "regulation of response to tumour cell" EXACT []
is_a: GO:0002831 ! regulation of response to biotic stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002347 ! response to tumor cell
relationship: regulates GO:0002347 ! response to tumor cell

[Term]
id: GO:0002835
name: negative regulation of response to tumor cell
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to tumor cell." [GOC:add]
synonym: "down regulation of response to tumor cell" EXACT []
synonym: "down-regulation of response to tumor cell" EXACT []
synonym: "downregulation of response to tumor cell" EXACT []
synonym: "inhibition of response to tumor cell" NARROW []
synonym: "negative regulation of response to tumour cell" EXACT []
is_a: GO:0002832 ! negative regulation of response to biotic stimulus
is_a: GO:0002834 ! regulation of response to tumor cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002347 ! response to tumor cell
relationship: negatively_regulates GO:0002347 ! response to tumor cell

[Term]
id: GO:0002836
name: positive regulation of response to tumor cell
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of a response to tumor cell." [GOC:add]
synonym: "activation of response to tumor cell" NARROW []
synonym: "positive regulation of response to tumour cell" EXACT []
synonym: "stimulation of response to tumor cell" NARROW []
synonym: "up regulation of response to tumor cell" EXACT []
synonym: "up-regulation of response to tumor cell" EXACT []
synonym: "upregulation of response to tumor cell" EXACT []
is_a: GO:0002833 ! positive regulation of response to biotic stimulus
is_a: GO:0002834 ! regulation of response to tumor cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002347 ! response to tumor cell
relationship: positively_regulates GO:0002347 ! response to tumor cell

[Term]
id: GO:0002837
name: regulation of immune response to tumor cell
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an immune response to tumor cell." [GOC:add]
synonym: "regulation of immune response to tumour cell" EXACT []
is_a: GO:0002834 ! regulation of response to tumor cell
is_a: GO:0050776 ! regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002418 ! immune response to tumor cell
relationship: regulates GO:0002418 ! immune response to tumor cell

[Term]
id: GO:0002838
name: negative regulation of immune response to tumor cell
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune response to tumor cell." [GOC:add]
synonym: "down regulation of immune response to tumor cell" EXACT []
synonym: "down-regulation of immune response to tumor cell" EXACT []
synonym: "downregulation of immune response to tumor cell" EXACT []
synonym: "inhibition of immune response to tumor cell" NARROW []
synonym: "negative regulation of immune response to tumour cell" EXACT []
is_a: GO:0002835 ! negative regulation of response to tumor cell
is_a: GO:0002837 ! regulation of immune response to tumor cell
is_a: GO:0050777 ! negative regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002418 ! immune response to tumor cell
relationship: negatively_regulates GO:0002418 ! immune response to tumor cell

[Term]
id: GO:0002839
name: positive regulation of immune response to tumor cell
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of an immune response to tumor cell." [GOC:add]
synonym: "activation of immune response to tumor cell" NARROW []
synonym: "positive regulation of immune response to tumour cell" EXACT []
synonym: "stimulation of immune response to tumor cell" NARROW []
synonym: "up regulation of immune response to tumor cell" EXACT []
synonym: "up-regulation of immune response to tumor cell" EXACT []
synonym: "upregulation of immune response to tumor cell" EXACT []
is_a: GO:0002836 ! positive regulation of response to tumor cell
is_a: GO:0002837 ! regulation of immune response to tumor cell
is_a: GO:0050778 ! positive regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002418 ! immune response to tumor cell
relationship: positively_regulates GO:0002418 ! immune response to tumor cell

[Term]
id: GO:0002840
name: regulation of T cell mediated immune response to tumor cell
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a T cell mediated immune response to tumor cell." [GOC:add]
synonym: "regulation of T cell mediated immune response to tumour cell" EXACT []
synonym: "regulation of T lymphocyte mediated immune response to tumor cell" EXACT []
synonym: "regulation of T-cell mediated immune response to tumor cell" EXACT []
synonym: "regulation of T-lymphocyte mediated immune response to tumor cell" EXACT []
is_a: GO:0002709 ! regulation of T cell mediated immunity
is_a: GO:0002837 ! regulation of immune response to tumor cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002424 ! T cell mediated immune response to tumor cell
relationship: regulates GO:0002424 ! T cell mediated immune response to tumor cell

[Term]
id: GO:0002841
name: negative regulation of T cell mediated immune response to tumor cell
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a T cell mediated immune response to tumor cell." [GOC:add]
synonym: "down regulation of T cell mediated immune response to tumor cell" EXACT []
synonym: "down-regulation of T cell mediated immune response to tumor cell" EXACT []
synonym: "downregulation of T cell mediated immune response to tumor cell" EXACT []
synonym: "inhibition of T cell mediated immune response to tumor cell" NARROW []
synonym: "negative regulation of T cell mediated immune response to tumour cell" EXACT []
synonym: "negative regulation of T lymphocyte mediated immune response to tumor cell" EXACT []
synonym: "negative regulation of T-cell mediated immune response to tumor cell" EXACT []
synonym: "negative regulation of T-lymphocyte mediated immune response to tumor cell" EXACT []
is_a: GO:0002710 ! negative regulation of T cell mediated immunity
is_a: GO:0002838 ! negative regulation of immune response to tumor cell
is_a: GO:0002840 ! regulation of T cell mediated immune response to tumor cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002424 ! T cell mediated immune response to tumor cell
relationship: negatively_regulates GO:0002424 ! T cell mediated immune response to tumor cell

[Term]
id: GO:0002842
name: positive regulation of T cell mediated immune response to tumor cell
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of a T cell mediated immune response to tumor cell." [GOC:add]
synonym: "activation of T cell mediated immune response to tumor cell" NARROW []
synonym: "positive regulation of T cell mediated immune response to tumour cell" EXACT []
synonym: "positive regulation of T lymphocyte mediated immune response to tumor cell" EXACT []
synonym: "positive regulation of T-cell mediated immune response to tumor cell" EXACT []
synonym: "positive regulation of T-lymphocyte mediated immune response to tumor cell" EXACT []
synonym: "stimulation of T cell mediated immune response to tumor cell" NARROW []
synonym: "up regulation of T cell mediated immune response to tumor cell" EXACT []
synonym: "up-regulation of T cell mediated immune response to tumor cell" EXACT []
synonym: "upregulation of T cell mediated immune response to tumor cell" EXACT []
is_a: GO:0002711 ! positive regulation of T cell mediated immunity
is_a: GO:0002839 ! positive regulation of immune response to tumor cell
is_a: GO:0002840 ! regulation of T cell mediated immune response to tumor cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002424 ! T cell mediated immune response to tumor cell
relationship: positively_regulates GO:0002424 ! T cell mediated immune response to tumor cell

[Term]
id: GO:0002843
name: regulation of tolerance induction to tumor cell
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of tolerance induction to tumor cell." [GOC:add]
synonym: "regulation of tolerance induction to tumour cell" EXACT []
is_a: GO:0002658 ! regulation of peripheral tolerance induction
is_a: GO:0002837 ! regulation of immune response to tumor cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002413 ! tolerance induction to tumor cell
relationship: regulates GO:0002413 ! tolerance induction to tumor cell

[Term]
id: GO:0002844
name: negative regulation of tolerance induction to tumor cell
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to tumor cell." [GOC:add]
synonym: "down regulation of tolerance induction to tumor cell" EXACT []
synonym: "down-regulation of tolerance induction to tumor cell" EXACT []
synonym: "downregulation of tolerance induction to tumor cell" EXACT []
synonym: "inhibition of tolerance induction to tumor cell" NARROW []
synonym: "negative regulation of tolerance induction to tumour cell" EXACT []
is_a: GO:0002659 ! negative regulation of peripheral tolerance induction
is_a: GO:0002838 ! negative regulation of immune response to tumor cell
is_a: GO:0002843 ! regulation of tolerance induction to tumor cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002413 ! tolerance induction to tumor cell
relationship: negatively_regulates GO:0002413 ! tolerance induction to tumor cell

[Term]
id: GO:0002845
name: positive regulation of tolerance induction to tumor cell
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction to tumor cell." [GOC:add]
synonym: "activation of tolerance induction to tumor cell" NARROW []
synonym: "positive regulation of tolerance induction to tumour cell" EXACT []
synonym: "stimulation of tolerance induction to tumor cell" NARROW []
synonym: "up regulation of tolerance induction to tumor cell" EXACT []
synonym: "up-regulation of tolerance induction to tumor cell" EXACT []
synonym: "upregulation of tolerance induction to tumor cell" EXACT []
is_a: GO:0002660 ! positive regulation of peripheral tolerance induction
is_a: GO:0002839 ! positive regulation of immune response to tumor cell
is_a: GO:0002843 ! regulation of tolerance induction to tumor cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002413 ! tolerance induction to tumor cell
relationship: positively_regulates GO:0002413 ! tolerance induction to tumor cell

[Term]
id: GO:0002846
name: regulation of T cell tolerance induction to tumor cell
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of T cell tolerance induction to tumor cell." [GOC:add]
is_a: GO:0002840 ! regulation of T cell mediated immune response to tumor cell
is_a: GO:0002843 ! regulation of tolerance induction to tumor cell
is_a: GO:0002849 ! regulation of peripheral T cell tolerance induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002411 ! T cell tolerance induction to tumor cell
relationship: regulates GO:0002411 ! T cell tolerance induction to tumor cell

[Term]
id: GO:0002847
name: negative regulation of T cell tolerance induction to tumor cell
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell tolerance induction to tumor cell." [GOC:add]
synonym: "down regulation of T cell tolerance induction to tumor cell" EXACT []
synonym: "down-regulation of T cell tolerance induction to tumor cell" EXACT []
synonym: "downregulation of T cell tolerance induction to tumor cell" EXACT []
synonym: "inhibition of T cell tolerance induction to tumor cell" NARROW []
is_a: GO:0002841 ! negative regulation of T cell mediated immune response to tumor cell
is_a: GO:0002844 ! negative regulation of tolerance induction to tumor cell
is_a: GO:0002846 ! regulation of T cell tolerance induction to tumor cell
is_a: GO:0002850 ! negative regulation of peripheral T cell tolerance induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002411 ! T cell tolerance induction to tumor cell
relationship: negatively_regulates GO:0002411 ! T cell tolerance induction to tumor cell

[Term]
id: GO:0002848
name: positive regulation of T cell tolerance induction to tumor cell
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction to tumor cell." [GOC:add]
synonym: "activation of T cell tolerance induction to tumor cell" NARROW []
synonym: "stimulation of T cell tolerance induction to tumor cell" NARROW []
synonym: "up regulation of T cell tolerance induction to tumor cell" EXACT []
synonym: "up-regulation of T cell tolerance induction to tumor cell" EXACT []
synonym: "upregulation of T cell tolerance induction to tumor cell" EXACT []
is_a: GO:0002842 ! positive regulation of T cell mediated immune response to tumor cell
is_a: GO:0002845 ! positive regulation of tolerance induction to tumor cell
is_a: GO:0002846 ! regulation of T cell tolerance induction to tumor cell
is_a: GO:0002851 ! positive regulation of peripheral T cell tolerance induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002411 ! T cell tolerance induction to tumor cell
relationship: positively_regulates GO:0002411 ! T cell tolerance induction to tumor cell

[Term]
id: GO:0002849
name: regulation of peripheral T cell tolerance induction
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of peripheral T cell tolerance induction." [GOC:add]
is_a: GO:0002658 ! regulation of peripheral tolerance induction
is_a: GO:0002664 ! regulation of T cell tolerance induction
is_a: GO:0002709 ! regulation of T cell mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002458 ! peripheral T cell tolerance induction
relationship: regulates GO:0002458 ! peripheral T cell tolerance induction

[Term]
id: GO:0002850
name: negative regulation of peripheral T cell tolerance induction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral T cell tolerance induction." [GOC:add]
synonym: "down regulation of peripheral T cell tolerance induction" EXACT []
synonym: "down-regulation of peripheral T cell tolerance induction" EXACT []
synonym: "downregulation of peripheral T cell tolerance induction" EXACT []
synonym: "inhibition of peripheral T cell tolerance induction" NARROW []
is_a: GO:0002659 ! negative regulation of peripheral tolerance induction
is_a: GO:0002665 ! negative regulation of T cell tolerance induction
is_a: GO:0002710 ! negative regulation of T cell mediated immunity
is_a: GO:0002849 ! regulation of peripheral T cell tolerance induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002458 ! peripheral T cell tolerance induction
relationship: negatively_regulates GO:0002458 ! peripheral T cell tolerance induction

[Term]
id: GO:0002851
name: positive regulation of peripheral T cell tolerance induction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of peripheral T cell tolerance induction." [GOC:add]
synonym: "activation of peripheral T cell tolerance induction" NARROW []
synonym: "stimulation of peripheral T cell tolerance induction" NARROW []
synonym: "up regulation of peripheral T cell tolerance induction" EXACT []
synonym: "up-regulation of peripheral T cell tolerance induction" EXACT []
synonym: "upregulation of peripheral T cell tolerance induction" EXACT []
is_a: GO:0002660 ! positive regulation of peripheral tolerance induction
is_a: GO:0002666 ! positive regulation of T cell tolerance induction
is_a: GO:0002711 ! positive regulation of T cell mediated immunity
is_a: GO:0002849 ! regulation of peripheral T cell tolerance induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002458 ! peripheral T cell tolerance induction
relationship: positively_regulates GO:0002458 ! peripheral T cell tolerance induction

[Term]
id: GO:0002852
name: regulation of T cell mediated cytotoxicity directed against tumor cell target
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target." [GOC:add]
is_a: GO:0001914 ! regulation of T cell mediated cytotoxicity
is_a: GO:0002840 ! regulation of T cell mediated immune response to tumor cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002419 ! T cell mediated cytotoxicity directed against tumor cell target
relationship: regulates GO:0002419 ! T cell mediated cytotoxicity directed against tumor cell target

[Term]
id: GO:0002853
name: negative regulation of T cell mediated cytotoxicity directed against tumor cell target
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target." [GOC:add]
synonym: "down regulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT []
synonym: "down-regulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT []
synonym: "downregulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT []
synonym: "inhibition of T cell mediated cytotoxicity directed against tumor cell target" NARROW []
is_a: GO:0001915 ! negative regulation of T cell mediated cytotoxicity
is_a: GO:0002841 ! negative regulation of T cell mediated immune response to tumor cell
is_a: GO:0002852 ! regulation of T cell mediated cytotoxicity directed against tumor cell target
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002419 ! T cell mediated cytotoxicity directed against tumor cell target
relationship: negatively_regulates GO:0002419 ! T cell mediated cytotoxicity directed against tumor cell target

[Term]
id: GO:0002854
name: positive regulation of T cell mediated cytotoxicity directed against tumor cell target
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target." [GOC:add]
synonym: "activation of T cell mediated cytotoxicity directed against tumor cell target" NARROW []
synonym: "stimulation of T cell mediated cytotoxicity directed against tumor cell target" NARROW []
synonym: "up regulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT []
synonym: "up-regulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT []
synonym: "upregulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT []
is_a: GO:0001916 ! positive regulation of T cell mediated cytotoxicity
is_a: GO:0002842 ! positive regulation of T cell mediated immune response to tumor cell
is_a: GO:0002852 ! regulation of T cell mediated cytotoxicity directed against tumor cell target
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002419 ! T cell mediated cytotoxicity directed against tumor cell target
relationship: positively_regulates GO:0002419 ! T cell mediated cytotoxicity directed against tumor cell target

[Term]
id: GO:0002855
name: regulation of natural killer cell mediated immune response to tumor cell
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell." [GOC:add]
is_a: GO:0002715 ! regulation of natural killer cell mediated immunity
is_a: GO:0002837 ! regulation of immune response to tumor cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002423 ! natural killer cell mediated immune response to tumor cell
relationship: regulates GO:0002423 ! natural killer cell mediated immune response to tumor cell

[Term]
id: GO:0002856
name: negative regulation of natural killer cell mediated immune response to tumor cell
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell." [GOC:add]
synonym: "down regulation of natural killer cell mediated immune response to tumor cell" EXACT []
synonym: "down-regulation of natural killer cell mediated immune response to tumor cell" EXACT []
synonym: "downregulation of natural killer cell mediated immune response to tumor cell" EXACT []
synonym: "inhibition of natural killer cell mediated immune response to tumor cell" NARROW []
is_a: GO:0002716 ! negative regulation of natural killer cell mediated immunity
is_a: GO:0002838 ! negative regulation of immune response to tumor cell
is_a: GO:0002855 ! regulation of natural killer cell mediated immune response to tumor cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002423 ! natural killer cell mediated immune response to tumor cell
relationship: negatively_regulates GO:0002423 ! natural killer cell mediated immune response to tumor cell

[Term]
id: GO:0002857
name: positive regulation of natural killer cell mediated immune response to tumor cell
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell." [GOC:add]
synonym: "activation of natural killer cell mediated immune response to tumor cell" NARROW []
synonym: "stimulation of natural killer cell mediated immune response to tumor cell" NARROW []
synonym: "up regulation of natural killer cell mediated immune response to tumor cell" EXACT []
synonym: "up-regulation of natural killer cell mediated immune response to tumor cell" EXACT []
synonym: "upregulation of natural killer cell mediated immune response to tumor cell" EXACT []
is_a: GO:0002717 ! positive regulation of natural killer cell mediated immunity
is_a: GO:0002839 ! positive regulation of immune response to tumor cell
is_a: GO:0002855 ! regulation of natural killer cell mediated immune response to tumor cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002423 ! natural killer cell mediated immune response to tumor cell
relationship: positively_regulates GO:0002423 ! natural killer cell mediated immune response to tumor cell

[Term]
id: GO:0002858
name: regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target." [GOC:add]
is_a: GO:0002855 ! regulation of natural killer cell mediated immune response to tumor cell
is_a: GO:0042269 ! regulation of natural killer cell mediated cytotoxicity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002420 ! natural killer cell mediated cytotoxicity directed against tumor cell target
relationship: regulates GO:0002420 ! natural killer cell mediated cytotoxicity directed against tumor cell target

[Term]
id: GO:0002859
name: negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target." [GOC:add]
synonym: "down regulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT []
synonym: "down-regulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT []
synonym: "downregulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT []
synonym: "inhibition of natural killer cell mediated cytotoxicity directed against tumor cell target" NARROW []
is_a: GO:0002856 ! negative regulation of natural killer cell mediated immune response to tumor cell
is_a: GO:0002858 ! regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
is_a: GO:0045953 ! negative regulation of natural killer cell mediated cytotoxicity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002420 ! natural killer cell mediated cytotoxicity directed against tumor cell target
relationship: negatively_regulates GO:0002420 ! natural killer cell mediated cytotoxicity directed against tumor cell target

[Term]
id: GO:0002860
name: positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target." [GOC:add]
synonym: "activation of natural killer cell mediated cytotoxicity directed against tumor cell target" NARROW []
synonym: "stimulation of natural killer cell mediated cytotoxicity directed against tumor cell target" NARROW []
synonym: "up regulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT []
synonym: "up-regulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT []
synonym: "upregulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT []
is_a: GO:0002857 ! positive regulation of natural killer cell mediated immune response to tumor cell
is_a: GO:0002858 ! regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
is_a: GO:0045954 ! positive regulation of natural killer cell mediated cytotoxicity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002420 ! natural killer cell mediated cytotoxicity directed against tumor cell target
relationship: positively_regulates GO:0002420 ! natural killer cell mediated cytotoxicity directed against tumor cell target

[Term]
id: GO:0002861
name: regulation of inflammatory response to antigenic stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an inflammatory response to an antigenic stimulus." [GOC:add]
is_a: GO:0050727 ! regulation of inflammatory response
is_a: GO:0050776 ! regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002437 ! inflammatory response to antigenic stimulus
relationship: regulates GO:0002437 ! inflammatory response to antigenic stimulus

[Term]
id: GO:0002862
name: negative regulation of inflammatory response to antigenic stimulus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an inflammatory response to an antigenic stimulus." [GOC:add]
synonym: "down regulation of inflammatory response to antigenic stimulus" EXACT []
synonym: "down-regulation of inflammatory response to antigenic stimulus" EXACT []
synonym: "downregulation of inflammatory response to antigenic stimulus" EXACT []
synonym: "inhibition of inflammatory response to antigenic stimulus" NARROW []
is_a: GO:0002861 ! regulation of inflammatory response to antigenic stimulus
is_a: GO:0050728 ! negative regulation of inflammatory response
is_a: GO:0050777 ! negative regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002437 ! inflammatory response to antigenic stimulus
relationship: negatively_regulates GO:0002437 ! inflammatory response to antigenic stimulus

[Term]
id: GO:0002863
name: positive regulation of inflammatory response to antigenic stimulus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of an inflammatory response to an antigenic stimulus." [GOC:add]
synonym: "activation of inflammatory response to antigenic stimulus" NARROW []
synonym: "stimulation of inflammatory response to antigenic stimulus" NARROW []
synonym: "up regulation of inflammatory response to antigenic stimulus" EXACT []
synonym: "up-regulation of inflammatory response to antigenic stimulus" EXACT []
synonym: "upregulation of inflammatory response to antigenic stimulus" EXACT []
is_a: GO:0002861 ! regulation of inflammatory response to antigenic stimulus
is_a: GO:0050729 ! positive regulation of inflammatory response
is_a: GO:0050778 ! positive regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002437 ! inflammatory response to antigenic stimulus
relationship: positively_regulates GO:0002437 ! inflammatory response to antigenic stimulus

[Term]
id: GO:0002864
name: regulation of acute inflammatory response to antigenic stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus." [GOC:add]
is_a: GO:0002673 ! regulation of acute inflammatory response
is_a: GO:0002861 ! regulation of inflammatory response to antigenic stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002438 ! acute inflammatory response to antigenic stimulus
relationship: regulates GO:0002438 ! acute inflammatory response to antigenic stimulus

[Term]
id: GO:0002865
name: negative regulation of acute inflammatory response to antigenic stimulus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus." [GOC:add]
synonym: "down regulation of acute inflammatory response to antigenic stimulus" EXACT []
synonym: "down-regulation of acute inflammatory response to antigenic stimulus" EXACT []
synonym: "downregulation of acute inflammatory response to antigenic stimulus" EXACT []
synonym: "inhibition of acute inflammatory response to antigenic stimulus" NARROW []
is_a: GO:0002674 ! negative regulation of acute inflammatory response
is_a: GO:0002862 ! negative regulation of inflammatory response to antigenic stimulus
is_a: GO:0002864 ! regulation of acute inflammatory response to antigenic stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002438 ! acute inflammatory response to antigenic stimulus
relationship: negatively_regulates GO:0002438 ! acute inflammatory response to antigenic stimulus

[Term]
id: GO:0002866
name: positive regulation of acute inflammatory response to antigenic stimulus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus." [GOC:add]
synonym: "activation of acute inflammatory response to antigenic stimulus" NARROW []
synonym: "stimulation of acute inflammatory response to antigenic stimulus" NARROW []
synonym: "up regulation of acute inflammatory response to antigenic stimulus" EXACT []
synonym: "up-regulation of acute inflammatory response to antigenic stimulus" EXACT []
synonym: "upregulation of acute inflammatory response to antigenic stimulus" EXACT []
is_a: GO:0002675 ! positive regulation of acute inflammatory response
is_a: GO:0002863 ! positive regulation of inflammatory response to antigenic stimulus
is_a: GO:0002864 ! regulation of acute inflammatory response to antigenic stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002438 ! acute inflammatory response to antigenic stimulus
relationship: positively_regulates GO:0002438 ! acute inflammatory response to antigenic stimulus

[Term]
id: GO:0002867
name: regulation of B cell deletion
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of B cell deletion." [GOC:add]
synonym: "regulation of B lymphocyte deletion" EXACT []
synonym: "regulation of B-cell deletion" EXACT []
synonym: "regulation of B-lymphocyte deletion" EXACT []
is_a: GO:0002661 ! regulation of B cell tolerance induction
is_a: GO:0002902 ! regulation of B cell apoptotic process
is_a: GO:1904748 ! regulation of apoptotic process involved in development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002516 ! B cell deletion
relationship: regulates GO:0002516 ! B cell deletion

[Term]
id: GO:0002868
name: negative regulation of B cell deletion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell deletion." [GOC:add]
synonym: "down regulation of B cell deletion" EXACT []
synonym: "down-regulation of B cell deletion" EXACT []
synonym: "downregulation of B cell deletion" EXACT []
synonym: "inhibition of B cell deletion" NARROW []
synonym: "negative regulation of B lymphocyte deletion" EXACT []
synonym: "negative regulation of B-cell deletion" EXACT []
synonym: "negative regulation of B-lymphocyte deletion" EXACT []
is_a: GO:0002662 ! negative regulation of B cell tolerance induction
is_a: GO:0002673 ! regulation of acute inflammatory response
is_a: GO:0002867 ! regulation of B cell deletion
is_a: GO:0002903 ! negative regulation of B cell apoptotic process
is_a: GO:1904746 ! negative regulation of apoptotic process involved in development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002516 ! B cell deletion
relationship: negatively_regulates GO:0002516 ! B cell deletion

[Term]
id: GO:0002869
name: positive regulation of B cell deletion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of B cell deletion." [GOC:add]
synonym: "activation of B cell deletion" NARROW []
synonym: "positive regulation of B lymphocyte deletion" EXACT []
synonym: "positive regulation of B-cell deletion" EXACT []
synonym: "positive regulation of B-lymphocyte deletion" EXACT []
synonym: "stimulation of B cell deletion" NARROW []
synonym: "up regulation of B cell deletion" EXACT []
synonym: "up-regulation of B cell deletion" EXACT []
synonym: "upregulation of B cell deletion" EXACT []
is_a: GO:0002663 ! positive regulation of B cell tolerance induction
is_a: GO:0002673 ! regulation of acute inflammatory response
is_a: GO:0002867 ! regulation of B cell deletion
is_a: GO:0002904 ! positive regulation of B cell apoptotic process
is_a: GO:1904747 ! positive regulation of apoptotic process involved in development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002516 ! B cell deletion
relationship: positively_regulates GO:0002516 ! B cell deletion

[Term]
id: GO:0002870
name: T cell anergy
namespace: biological_process
def: "Any process contributing to anergy in T cells, a state of functional inactivation which is part of T cell tolerance induction." [GOC:add, ISBN:0781735149]
synonym: "T lymphocyte anergy" EXACT []
synonym: "T-cell anergy" EXACT []
synonym: "T-lymphocyte anergy" EXACT []
is_a: GO:0002249 ! lymphocyte anergy
is_a: GO:0002517 ! T cell tolerance induction

[Term]
id: GO:0002871
name: regulation of natural killer cell tolerance induction
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of natural killer cell tolerance induction." [GOC:add]
synonym: "regulation of NK cell tolerance induction" EXACT []
is_a: GO:0002643 ! regulation of tolerance induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002519 ! natural killer cell tolerance induction
relationship: regulates GO:0002519 ! natural killer cell tolerance induction

[Term]
id: GO:0002872
name: negative regulation of natural killer cell tolerance induction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell tolerance induction." [GOC:add]
synonym: "down regulation of natural killer cell tolerance induction" EXACT []
synonym: "down-regulation of natural killer cell tolerance induction" EXACT []
synonym: "downregulation of natural killer cell tolerance induction" EXACT []
synonym: "inhibition of natural killer cell tolerance induction" NARROW []
synonym: "negative regulation of NK cell tolerance induction" EXACT []
is_a: GO:0002644 ! negative regulation of tolerance induction
is_a: GO:0002673 ! regulation of acute inflammatory response
is_a: GO:0002871 ! regulation of natural killer cell tolerance induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002519 ! natural killer cell tolerance induction
relationship: negatively_regulates GO:0002519 ! natural killer cell tolerance induction

[Term]
id: GO:0002873
name: positive regulation of natural killer cell tolerance induction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell tolerance induction." [GOC:add]
synonym: "activation of natural killer cell tolerance induction" NARROW []
synonym: "positive regulation of NK cell tolerance induction" EXACT []
synonym: "stimulation of natural killer cell tolerance induction" NARROW []
synonym: "up regulation of natural killer cell tolerance induction" EXACT []
synonym: "up-regulation of natural killer cell tolerance induction" EXACT []
synonym: "upregulation of natural killer cell tolerance induction" EXACT []
is_a: GO:0002645 ! positive regulation of tolerance induction
is_a: GO:0002673 ! regulation of acute inflammatory response
is_a: GO:0002871 ! regulation of natural killer cell tolerance induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002519 ! natural killer cell tolerance induction
relationship: positively_regulates GO:0002519 ! natural killer cell tolerance induction

[Term]
id: GO:0002874
name: regulation of chronic inflammatory response to antigenic stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus." [GOC:add]
is_a: GO:0002676 ! regulation of chronic inflammatory response
is_a: GO:0002861 ! regulation of inflammatory response to antigenic stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002439 ! chronic inflammatory response to antigenic stimulus
relationship: regulates GO:0002439 ! chronic inflammatory response to antigenic stimulus

[Term]
id: GO:0002875
name: negative regulation of chronic inflammatory response to antigenic stimulus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus." [GOC:add]
synonym: "down regulation of chronic inflammatory response to antigenic stimulus" EXACT []
synonym: "down-regulation of chronic inflammatory response to antigenic stimulus" EXACT []
synonym: "downregulation of chronic inflammatory response to antigenic stimulus" EXACT []
synonym: "inhibition of chronic inflammatory response to antigenic stimulus" NARROW []
is_a: GO:0002677 ! negative regulation of chronic inflammatory response
is_a: GO:0002862 ! negative regulation of inflammatory response to antigenic stimulus
is_a: GO:0002874 ! regulation of chronic inflammatory response to antigenic stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002439 ! chronic inflammatory response to antigenic stimulus
relationship: negatively_regulates GO:0002439 ! chronic inflammatory response to antigenic stimulus

[Term]
id: GO:0002876
name: positive regulation of chronic inflammatory response to antigenic stimulus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus." [GOC:add]
synonym: "activation of chronic inflammatory response to antigenic stimulus" NARROW []
synonym: "stimulation of chronic inflammatory response to antigenic stimulus" NARROW []
synonym: "up regulation of chronic inflammatory response to antigenic stimulus" EXACT []
synonym: "up-regulation of chronic inflammatory response to antigenic stimulus" EXACT []
synonym: "upregulation of chronic inflammatory response to antigenic stimulus" EXACT []
is_a: GO:0002678 ! positive regulation of chronic inflammatory response
is_a: GO:0002863 ! positive regulation of inflammatory response to antigenic stimulus
is_a: GO:0002874 ! regulation of chronic inflammatory response to antigenic stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002439 ! chronic inflammatory response to antigenic stimulus
relationship: positively_regulates GO:0002439 ! chronic inflammatory response to antigenic stimulus

[Term]
id: GO:0002877
name: regulation of acute inflammatory response to non-antigenic stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus." [GOC:add]
is_a: GO:0002673 ! regulation of acute inflammatory response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002525 ! acute inflammatory response to non-antigenic stimulus
relationship: regulates GO:0002525 ! acute inflammatory response to non-antigenic stimulus

[Term]
id: GO:0002878
name: negative regulation of acute inflammatory response to non-antigenic stimulus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus." [GOC:add]
synonym: "down regulation of acute inflammatory response to non-antigenic stimulus" EXACT []
synonym: "down-regulation of acute inflammatory response to non-antigenic stimulus" EXACT []
synonym: "downregulation of acute inflammatory response to non-antigenic stimulus" EXACT []
synonym: "inhibition of acute inflammatory response to non-antigenic stimulus" NARROW []
is_a: GO:0002674 ! negative regulation of acute inflammatory response
is_a: GO:0002877 ! regulation of acute inflammatory response to non-antigenic stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002525 ! acute inflammatory response to non-antigenic stimulus
relationship: negatively_regulates GO:0002525 ! acute inflammatory response to non-antigenic stimulus

[Term]
id: GO:0002879
name: positive regulation of acute inflammatory response to non-antigenic stimulus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus." [GOC:add]
synonym: "activation of acute inflammatory response to non-antigenic stimulus" NARROW []
synonym: "stimulation of acute inflammatory response to non-antigenic stimulus" NARROW []
synonym: "up regulation of acute inflammatory response to non-antigenic stimulus" EXACT []
synonym: "up-regulation of acute inflammatory response to non-antigenic stimulus" EXACT []
synonym: "upregulation of acute inflammatory response to non-antigenic stimulus" EXACT []
is_a: GO:0002675 ! positive regulation of acute inflammatory response
is_a: GO:0002877 ! regulation of acute inflammatory response to non-antigenic stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002525 ! acute inflammatory response to non-antigenic stimulus
relationship: positively_regulates GO:0002525 ! acute inflammatory response to non-antigenic stimulus

[Term]
id: GO:0002880
name: regulation of chronic inflammatory response to non-antigenic stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus." [GOC:add]
is_a: GO:0002676 ! regulation of chronic inflammatory response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002545 ! chronic inflammatory response to non-antigenic stimulus
relationship: regulates GO:0002545 ! chronic inflammatory response to non-antigenic stimulus

[Term]
id: GO:0002881
name: negative regulation of chronic inflammatory response to non-antigenic stimulus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus." [GOC:add]
synonym: "down regulation of chronic inflammatory response to non-antigenic stimulus" EXACT []
synonym: "down-regulation of chronic inflammatory response to non-antigenic stimulus" EXACT []
synonym: "downregulation of chronic inflammatory response to non-antigenic stimulus" EXACT []
synonym: "inhibition of chronic inflammatory response to non-antigenic stimulus" NARROW []
is_a: GO:0002677 ! negative regulation of chronic inflammatory response
is_a: GO:0002880 ! regulation of chronic inflammatory response to non-antigenic stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002545 ! chronic inflammatory response to non-antigenic stimulus
relationship: negatively_regulates GO:0002545 ! chronic inflammatory response to non-antigenic stimulus

[Term]
id: GO:0002882
name: positive regulation of chronic inflammatory response to non-antigenic stimulus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus." [GOC:add]
synonym: "activation of chronic inflammatory response to non-antigenic stimulus" NARROW []
synonym: "stimulation of chronic inflammatory response to non-antigenic stimulus" NARROW []
synonym: "up regulation of chronic inflammatory response to non-antigenic stimulus" EXACT []
synonym: "up-regulation of chronic inflammatory response to non-antigenic stimulus" EXACT []
synonym: "upregulation of chronic inflammatory response to non-antigenic stimulus" EXACT []
is_a: GO:0002678 ! positive regulation of chronic inflammatory response
is_a: GO:0002880 ! regulation of chronic inflammatory response to non-antigenic stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002545 ! chronic inflammatory response to non-antigenic stimulus
relationship: positively_regulates GO:0002545 ! chronic inflammatory response to non-antigenic stimulus

[Term]
id: GO:0002883
name: regulation of hypersensitivity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of hypersensitivity." [GOC:add]
is_a: GO:0002864 ! regulation of acute inflammatory response to antigenic stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002524 ! hypersensitivity
relationship: regulates GO:0002524 ! hypersensitivity

[Term]
id: GO:0002884
name: negative regulation of hypersensitivity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of hypersensitivity." [GOC:add]
synonym: "down regulation of hypersensitivity" EXACT []
synonym: "down-regulation of hypersensitivity" EXACT []
synonym: "downregulation of hypersensitivity" EXACT []
synonym: "inhibition of hypersensitivity" NARROW []
is_a: GO:0002865 ! negative regulation of acute inflammatory response to antigenic stimulus
is_a: GO:0002883 ! regulation of hypersensitivity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002524 ! hypersensitivity
relationship: negatively_regulates GO:0002524 ! hypersensitivity

[Term]
id: GO:0002885
name: positive regulation of hypersensitivity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of hypersensitivity." [GOC:add]
synonym: "activation of hypersensitivity" NARROW []
synonym: "stimulation of hypersensitivity" NARROW []
synonym: "up regulation of hypersensitivity" EXACT []
synonym: "up-regulation of hypersensitivity" EXACT []
synonym: "upregulation of hypersensitivity" EXACT []
is_a: GO:0002866 ! positive regulation of acute inflammatory response to antigenic stimulus
is_a: GO:0002883 ! regulation of hypersensitivity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002524 ! hypersensitivity
relationship: positively_regulates GO:0002524 ! hypersensitivity

[Term]
id: GO:0002886
name: regulation of myeloid leukocyte mediated immunity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add]
is_a: GO:0002703 ! regulation of leukocyte mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002444 ! myeloid leukocyte mediated immunity
relationship: regulates GO:0002444 ! myeloid leukocyte mediated immunity

[Term]
id: GO:0002887
name: negative regulation of myeloid leukocyte mediated immunity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add]
synonym: "down regulation of myeloid leukocyte mediated immunity" EXACT []
synonym: "down-regulation of myeloid leukocyte mediated immunity" EXACT []
synonym: "downregulation of myeloid leukocyte mediated immunity" EXACT []
synonym: "inhibition of myeloid leukocyte mediated immunity" NARROW []
is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity
is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002444 ! myeloid leukocyte mediated immunity
relationship: negatively_regulates GO:0002444 ! myeloid leukocyte mediated immunity

[Term]
id: GO:0002888
name: positive regulation of myeloid leukocyte mediated immunity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add]
synonym: "activation of myeloid leukocyte mediated immunity" NARROW []
synonym: "stimulation of myeloid leukocyte mediated immunity" NARROW []
synonym: "up regulation of myeloid leukocyte mediated immunity" EXACT []
synonym: "up-regulation of myeloid leukocyte mediated immunity" EXACT []
synonym: "upregulation of myeloid leukocyte mediated immunity" EXACT []
is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity
is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002444 ! myeloid leukocyte mediated immunity
relationship: positively_regulates GO:0002444 ! myeloid leukocyte mediated immunity

[Term]
id: GO:0002889
name: regulation of immunoglobulin mediated immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an immunoglobulin mediated immune response." [GOC:add]
is_a: GO:0002712 ! regulation of B cell mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016064 ! immunoglobulin mediated immune response
relationship: regulates GO:0016064 ! immunoglobulin mediated immune response

[Term]
id: GO:0002890
name: negative regulation of immunoglobulin mediated immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immunoglobulin mediated immune response." [GOC:add]
synonym: "down regulation of immunoglobulin mediated immune response" EXACT []
synonym: "down-regulation of immunoglobulin mediated immune response" EXACT []
synonym: "downregulation of immunoglobulin mediated immune response" EXACT []
synonym: "inhibition of immunoglobulin mediated immune response" NARROW []
is_a: GO:0002713 ! negative regulation of B cell mediated immunity
is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016064 ! immunoglobulin mediated immune response
relationship: negatively_regulates GO:0016064 ! immunoglobulin mediated immune response

[Term]
id: GO:0002891
name: positive regulation of immunoglobulin mediated immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of an immunoglobulin mediated immune response." [GOC:add]
synonym: "activation of immunoglobulin mediated immune response" NARROW []
synonym: "stimulation of immunoglobulin mediated immune response" NARROW []
synonym: "up regulation of immunoglobulin mediated immune response" EXACT []
synonym: "up-regulation of immunoglobulin mediated immune response" EXACT []
synonym: "upregulation of immunoglobulin mediated immune response" EXACT []
is_a: GO:0002714 ! positive regulation of B cell mediated immunity
is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016064 ! immunoglobulin mediated immune response
relationship: positively_regulates GO:0016064 ! immunoglobulin mediated immune response

[Term]
id: GO:0002892
name: regulation of type II hypersensitivity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of type II hypersensitivity." [GOC:add]
is_a: GO:0002883 ! regulation of hypersensitivity
is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity
is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002445 ! type II hypersensitivity
relationship: regulates GO:0002445 ! type II hypersensitivity

[Term]
id: GO:0002893
name: negative regulation of type II hypersensitivity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of type II hypersensitivity." [GOC:add]
synonym: "down regulation of type II hypersensitivity" EXACT []
synonym: "down-regulation of type II hypersensitivity" EXACT []
synonym: "downregulation of type II hypersensitivity" EXACT []
synonym: "inhibition of type II hypersensitivity" NARROW []
is_a: GO:0002884 ! negative regulation of hypersensitivity
is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity
is_a: GO:0002890 ! negative regulation of immunoglobulin mediated immune response
is_a: GO:0002892 ! regulation of type II hypersensitivity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002445 ! type II hypersensitivity
relationship: negatively_regulates GO:0002445 ! type II hypersensitivity

[Term]
id: GO:0002894
name: positive regulation of type II hypersensitivity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of type II hypersensitivity." [GOC:add]
synonym: "activation of type II hypersensitivity" NARROW []
synonym: "stimulation of type II hypersensitivity" NARROW []
synonym: "up regulation of type II hypersensitivity" EXACT []
synonym: "up-regulation of type II hypersensitivity" EXACT []
synonym: "upregulation of type II hypersensitivity" EXACT []
is_a: GO:0002885 ! positive regulation of hypersensitivity
is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity
is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response
is_a: GO:0002892 ! regulation of type II hypersensitivity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002445 ! type II hypersensitivity
relationship: positively_regulates GO:0002445 ! type II hypersensitivity

[Term]
id: GO:0002895
name: regulation of central B cell tolerance induction
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of central B cell tolerance induction." [GOC:add]
is_a: GO:0002646 ! regulation of central tolerance induction
is_a: GO:0002661 ! regulation of B cell tolerance induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002510 ! central B cell tolerance induction
relationship: regulates GO:0002510 ! central B cell tolerance induction

[Term]
id: GO:0002896
name: negative regulation of central B cell tolerance induction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell tolerance induction." [GOC:add]
synonym: "down regulation of central B cell tolerance induction" EXACT []
synonym: "down-regulation of central B cell tolerance induction" EXACT []
synonym: "downregulation of central B cell tolerance induction" EXACT []
synonym: "inhibition of central B cell tolerance induction" NARROW []
is_a: GO:0002647 ! negative regulation of central tolerance induction
is_a: GO:0002662 ! negative regulation of B cell tolerance induction
is_a: GO:0002895 ! regulation of central B cell tolerance induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002510 ! central B cell tolerance induction
relationship: negatively_regulates GO:0002510 ! central B cell tolerance induction

[Term]
id: GO:0002897
name: positive regulation of central B cell tolerance induction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of central B cell tolerance induction." [GOC:add]
synonym: "activation of central B cell tolerance induction" NARROW []
synonym: "stimulation of central B cell tolerance induction" NARROW []
synonym: "up regulation of central B cell tolerance induction" EXACT []
synonym: "up-regulation of central B cell tolerance induction" EXACT []
synonym: "upregulation of central B cell tolerance induction" EXACT []
is_a: GO:0002648 ! positive regulation of central tolerance induction
is_a: GO:0002663 ! positive regulation of B cell tolerance induction
is_a: GO:0002895 ! regulation of central B cell tolerance induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002510 ! central B cell tolerance induction
relationship: positively_regulates GO:0002510 ! central B cell tolerance induction

[Term]
id: GO:0002898
name: regulation of central B cell deletion
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of central B cell deletion." [GOC:add]
is_a: GO:0002867 ! regulation of B cell deletion
is_a: GO:0002895 ! regulation of central B cell tolerance induction
is_a: GO:0045577 ! regulation of B cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002342 ! central B cell deletion
relationship: regulates GO:0002342 ! central B cell deletion

[Term]
id: GO:0002899
name: negative regulation of central B cell deletion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell deletion." [GOC:add]
synonym: "down regulation of central B cell deletion" EXACT []
synonym: "down-regulation of central B cell deletion" EXACT []
synonym: "downregulation of central B cell deletion" EXACT []
synonym: "inhibition of central B cell deletion" NARROW []
is_a: GO:0002868 ! negative regulation of B cell deletion
is_a: GO:0002896 ! negative regulation of central B cell tolerance induction
is_a: GO:0002898 ! regulation of central B cell deletion
is_a: GO:0045578 ! negative regulation of B cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002342 ! central B cell deletion
relationship: negatively_regulates GO:0002342 ! central B cell deletion

[Term]
id: GO:0002900
name: positive regulation of central B cell deletion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of central B cell deletion." [GOC:add]
synonym: "activation of central B cell deletion" NARROW []
synonym: "stimulation of central B cell deletion" NARROW []
synonym: "up regulation of central B cell deletion" EXACT []
synonym: "up-regulation of central B cell deletion" EXACT []
synonym: "upregulation of central B cell deletion" EXACT []
is_a: GO:0002869 ! positive regulation of B cell deletion
is_a: GO:0002897 ! positive regulation of central B cell tolerance induction
is_a: GO:0002898 ! regulation of central B cell deletion
is_a: GO:0045579 ! positive regulation of B cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002342 ! central B cell deletion
relationship: positively_regulates GO:0002342 ! central B cell deletion

[Term]
id: GO:0002901
name: mature B cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a B cell that is mature, having left the bone marrow." [CL:0000785, GOC:add, GOC:mtg_apoptosis, ISBN:0781735149]
synonym: "apoptosis of mature B cells" EXACT []
synonym: "apoptosis of mature B lymphocytes" EXACT []
synonym: "apoptosis of mature B-cells" EXACT []
synonym: "apoptosis of mature B-lymphocytes" EXACT []
synonym: "mature B cell apoptosis" NARROW []
synonym: "mature B cell programmed cell death by apoptosis" EXACT []
synonym: "mature B lymphocyte apoptosis" EXACT []
synonym: "mature B lymphocyte programmed cell death by apoptosis" EXACT []
synonym: "mature B-cell apoptosis" EXACT []
synonym: "mature B-cell programmed cell death by apoptosis" EXACT []
synonym: "mature B-lymphocyte apoptosis" EXACT []
synonym: "mature B-lymphocyte programmed cell death by apoptosis" EXACT []
synonym: "programmed cell death of mature B cells by apoptosis" EXACT []
synonym: "programmed cell death of mature B lymphocytes by apoptosis" EXACT []
synonym: "programmed cell death of mature B-cells by apoptosis" EXACT []
synonym: "programmed cell death of mature B-lymphocytes by apoptosis" EXACT []
synonym: "programmed cell death, mature B cells" EXACT []
synonym: "programmed cell death, mature B lymphocytes" EXACT []
synonym: "programmed cell death, mature B-cells" EXACT []
synonym: "programmed cell death, mature B-lymphocytes" EXACT []
is_a: GO:0001783 ! B cell apoptotic process
relationship: part_of GO:0001782 ! B cell homeostasis

[Term]
id: GO:0002902
name: regulation of B cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis]
synonym: "regulation of B cell apoptosis" NARROW []
is_a: GO:0070228 ! regulation of lymphocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001783 ! B cell apoptotic process
relationship: regulates GO:0001783 ! B cell apoptotic process

[Term]
id: GO:0002903
name: negative regulation of B cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis]
synonym: "down regulation of B cell apoptosis" EXACT []
synonym: "down-regulation of B cell apoptosis" EXACT []
synonym: "downregulation of B cell apoptosis" EXACT []
synonym: "inhibition of B cell apoptosis" NARROW []
synonym: "negative regulation of B cell apoptosis" NARROW []
is_a: GO:0002902 ! regulation of B cell apoptotic process
is_a: GO:0070229 ! negative regulation of lymphocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001783 ! B cell apoptotic process
relationship: negatively_regulates GO:0001783 ! B cell apoptotic process

[Term]
id: GO:0002904
name: positive regulation of B cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis]
synonym: "activation of B cell apoptosis" NARROW []
synonym: "positive regulation of B cell apoptosis" NARROW []
synonym: "stimulation of B cell apoptosis" NARROW []
synonym: "up regulation of B cell apoptosis" EXACT []
synonym: "up-regulation of B cell apoptosis" EXACT []
synonym: "upregulation of B cell apoptosis" EXACT []
is_a: GO:0002902 ! regulation of B cell apoptotic process
is_a: GO:0070230 ! positive regulation of lymphocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001783 ! B cell apoptotic process
relationship: positively_regulates GO:0001783 ! B cell apoptotic process

[Term]
id: GO:0002905
name: regulation of mature B cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of mature B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis]
synonym: "regulation of mature B cell apoptosis" NARROW []
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0002902 ! regulation of B cell apoptotic process
is_a: GO:0032844 ! regulation of homeostatic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002901 ! mature B cell apoptotic process
relationship: regulates GO:0002901 ! mature B cell apoptotic process

[Term]
id: GO:0002906
name: negative regulation of mature B cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of mature B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis]
synonym: "down regulation of mature B cell apoptosis" EXACT []
synonym: "down-regulation of mature B cell apoptosis" EXACT []
synonym: "downregulation of mature B cell apoptosis" EXACT []
synonym: "inhibition of mature B cell apoptosis" NARROW []
synonym: "negative regulation of mature B cell apoptosis" NARROW []
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0002903 ! negative regulation of B cell apoptotic process
is_a: GO:0002905 ! regulation of mature B cell apoptotic process
is_a: GO:0032845 ! negative regulation of homeostatic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002901 ! mature B cell apoptotic process
relationship: negatively_regulates GO:0002901 ! mature B cell apoptotic process

[Term]
id: GO:0002907
name: positive regulation of mature B cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of mature B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis]
synonym: "activation of mature B cell apoptosis" NARROW []
synonym: "positive regulation of mature B cell apoptosis" NARROW []
synonym: "stimulation of mature B cell apoptosis" NARROW []
synonym: "up regulation of mature B cell apoptosis" EXACT []
synonym: "up-regulation of mature B cell apoptosis" EXACT []
synonym: "upregulation of mature B cell apoptosis" EXACT []
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0002904 ! positive regulation of B cell apoptotic process
is_a: GO:0002905 ! regulation of mature B cell apoptotic process
is_a: GO:0032846 ! positive regulation of homeostatic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002901 ! mature B cell apoptotic process
relationship: positively_regulates GO:0002901 ! mature B cell apoptotic process

[Term]
id: GO:0002908
name: regulation of peripheral B cell deletion
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of peripheral B cell deletion." [GOC:add]
is_a: GO:0002658 ! regulation of peripheral tolerance induction
is_a: GO:0002712 ! regulation of B cell mediated immunity
is_a: GO:0002867 ! regulation of B cell deletion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002454 ! peripheral B cell deletion
relationship: regulates GO:0002454 ! peripheral B cell deletion

[Term]
id: GO:0002909
name: negative regulation of peripheral B cell deletion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral B cell deletion." [GOC:add]
synonym: "down regulation of peripheral B cell deletion" EXACT []
synonym: "down-regulation of peripheral B cell deletion" EXACT []
synonym: "downregulation of peripheral B cell deletion" EXACT []
synonym: "inhibition of peripheral B cell deletion" NARROW []
is_a: GO:0002659 ! negative regulation of peripheral tolerance induction
is_a: GO:0002713 ! negative regulation of B cell mediated immunity
is_a: GO:0002868 ! negative regulation of B cell deletion
is_a: GO:0002908 ! regulation of peripheral B cell deletion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002454 ! peripheral B cell deletion
relationship: negatively_regulates GO:0002454 ! peripheral B cell deletion

[Term]
id: GO:0002910
name: positive regulation of peripheral B cell deletion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of peripheral B cell deletion." [GOC:add]
synonym: "activation of peripheral B cell deletion" NARROW []
synonym: "stimulation of peripheral B cell deletion" NARROW []
synonym: "up regulation of peripheral B cell deletion" EXACT []
synonym: "up-regulation of peripheral B cell deletion" EXACT []
synonym: "upregulation of peripheral B cell deletion" EXACT []
is_a: GO:0002660 ! positive regulation of peripheral tolerance induction
is_a: GO:0002714 ! positive regulation of B cell mediated immunity
is_a: GO:0002869 ! positive regulation of B cell deletion
is_a: GO:0002908 ! regulation of peripheral B cell deletion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002454 ! peripheral B cell deletion
relationship: positively_regulates GO:0002454 ! peripheral B cell deletion

[Term]
id: GO:0002911
name: regulation of lymphocyte anergy
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of lymphocyte anergy." [GOC:add]
is_a: GO:0002643 ! regulation of tolerance induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002249 ! lymphocyte anergy
relationship: regulates GO:0002249 ! lymphocyte anergy

[Term]
id: GO:0002912
name: negative regulation of lymphocyte anergy
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte anergy." [GOC:add]
synonym: "down regulation of lymphocyte anergy" EXACT []
synonym: "down-regulation of lymphocyte anergy" EXACT []
synonym: "downregulation of lymphocyte anergy" EXACT []
synonym: "inhibition of lymphocyte anergy" NARROW []
is_a: GO:0002644 ! negative regulation of tolerance induction
is_a: GO:0002911 ! regulation of lymphocyte anergy
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002249 ! lymphocyte anergy
relationship: negatively_regulates GO:0002249 ! lymphocyte anergy

[Term]
id: GO:0002913
name: positive regulation of lymphocyte anergy
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of lymphocyte anergy." [GOC:add]
synonym: "activation of lymphocyte anergy" NARROW []
synonym: "stimulation of lymphocyte anergy" NARROW []
synonym: "up regulation of lymphocyte anergy" EXACT []
synonym: "up-regulation of lymphocyte anergy" EXACT []
synonym: "upregulation of lymphocyte anergy" EXACT []
is_a: GO:0002645 ! positive regulation of tolerance induction
is_a: GO:0002911 ! regulation of lymphocyte anergy
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002249 ! lymphocyte anergy
relationship: positively_regulates GO:0002249 ! lymphocyte anergy

[Term]
id: GO:0002914
name: regulation of central B cell anergy
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of central B cell anergy." [GOC:add]
is_a: GO:0002670 ! regulation of B cell anergy
is_a: GO:0002895 ! regulation of central B cell tolerance induction
is_a: GO:0045577 ! regulation of B cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002341 ! central B cell anergy
relationship: regulates GO:0002341 ! central B cell anergy

[Term]
id: GO:0002915
name: negative regulation of central B cell anergy
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell anergy." [GOC:add]
synonym: "down regulation of central B cell anergy" EXACT []
synonym: "down-regulation of central B cell anergy" EXACT []
synonym: "downregulation of central B cell anergy" EXACT []
synonym: "inhibition of central B cell anergy" NARROW []
is_a: GO:0002671 ! negative regulation of B cell anergy
is_a: GO:0002896 ! negative regulation of central B cell tolerance induction
is_a: GO:0002914 ! regulation of central B cell anergy
is_a: GO:0045578 ! negative regulation of B cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002341 ! central B cell anergy
relationship: negatively_regulates GO:0002341 ! central B cell anergy

[Term]
id: GO:0002916
name: positive regulation of central B cell anergy
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of central B cell anergy." [GOC:add]
synonym: "activation of central B cell anergy" NARROW []
synonym: "stimulation of central B cell anergy" NARROW []
synonym: "up regulation of central B cell anergy" EXACT []
synonym: "up-regulation of central B cell anergy" EXACT []
synonym: "upregulation of central B cell anergy" EXACT []
is_a: GO:0002672 ! positive regulation of B cell anergy
is_a: GO:0002897 ! positive regulation of central B cell tolerance induction
is_a: GO:0002914 ! regulation of central B cell anergy
is_a: GO:0045579 ! positive regulation of B cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002341 ! central B cell anergy
relationship: positively_regulates GO:0002341 ! central B cell anergy

[Term]
id: GO:0002917
name: regulation of peripheral B cell anergy
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of peripheral B cell anergy." [GOC:add]
is_a: GO:0002658 ! regulation of peripheral tolerance induction
is_a: GO:0002670 ! regulation of B cell anergy
is_a: GO:0002712 ! regulation of B cell mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002453 ! peripheral B cell anergy
relationship: regulates GO:0002453 ! peripheral B cell anergy

[Term]
id: GO:0002918
name: negative regulation of peripheral B cell anergy
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral B cell anergy." [GOC:add]
synonym: "down regulation of peripheral B cell anergy" EXACT []
synonym: "down-regulation of peripheral B cell anergy" EXACT []
synonym: "downregulation of peripheral B cell anergy" EXACT []
synonym: "inhibition of peripheral B cell anergy" NARROW []
is_a: GO:0002659 ! negative regulation of peripheral tolerance induction
is_a: GO:0002671 ! negative regulation of B cell anergy
is_a: GO:0002713 ! negative regulation of B cell mediated immunity
is_a: GO:0002917 ! regulation of peripheral B cell anergy
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002453 ! peripheral B cell anergy
relationship: negatively_regulates GO:0002453 ! peripheral B cell anergy

[Term]
id: GO:0002919
name: positive regulation of peripheral B cell anergy
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of peripheral B cell anergy." [GOC:add]
synonym: "activation of peripheral B cell anergy" NARROW []
synonym: "stimulation of peripheral B cell anergy" NARROW []
synonym: "up regulation of peripheral B cell anergy" EXACT []
synonym: "up-regulation of peripheral B cell anergy" EXACT []
synonym: "upregulation of peripheral B cell anergy" EXACT []
is_a: GO:0002660 ! positive regulation of peripheral tolerance induction
is_a: GO:0002672 ! positive regulation of B cell anergy
is_a: GO:0002714 ! positive regulation of B cell mediated immunity
is_a: GO:0002917 ! regulation of peripheral B cell anergy
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002453 ! peripheral B cell anergy
relationship: positively_regulates GO:0002453 ! peripheral B cell anergy

[Term]
id: GO:0002920
name: regulation of humoral immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a humoral immune response." [GOC:add]
is_a: GO:0050776 ! regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006959 ! humoral immune response
relationship: regulates GO:0006959 ! humoral immune response

[Term]
id: GO:0002921
name: negative regulation of humoral immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response." [GOC:add]
synonym: "down regulation of humoral immune response" EXACT []
synonym: "down-regulation of humoral immune response" EXACT []
synonym: "downregulation of humoral immune response" EXACT []
synonym: "inhibition of humoral immune response" NARROW []
is_a: GO:0002920 ! regulation of humoral immune response
is_a: GO:0050777 ! negative regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006959 ! humoral immune response
relationship: negatively_regulates GO:0006959 ! humoral immune response

[Term]
id: GO:0002922
name: positive regulation of humoral immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of a humoral immune response." [GOC:add]
synonym: "activation of humoral immune response" NARROW []
synonym: "stimulation of humoral immune response" NARROW []
synonym: "up regulation of humoral immune response" EXACT []
synonym: "up-regulation of humoral immune response" EXACT []
synonym: "upregulation of humoral immune response" EXACT []
is_a: GO:0002920 ! regulation of humoral immune response
is_a: GO:0050778 ! positive regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006959 ! humoral immune response
relationship: positively_regulates GO:0006959 ! humoral immune response

[Term]
id: GO:0002923
name: regulation of humoral immune response mediated by circulating immunoglobulin
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin." [GOC:add]
is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response
is_a: GO:0002920 ! regulation of humoral immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002455 ! humoral immune response mediated by circulating immunoglobulin
relationship: regulates GO:0002455 ! humoral immune response mediated by circulating immunoglobulin

[Term]
id: GO:0002924
name: negative regulation of humoral immune response mediated by circulating immunoglobulin
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin." [GOC:add]
synonym: "down regulation of humoral immune response mediated by circulating immunoglobulin" EXACT []
synonym: "down-regulation of humoral immune response mediated by circulating immunoglobulin" EXACT []
synonym: "downregulation of humoral immune response mediated by circulating immunoglobulin" EXACT []
synonym: "inhibition of humoral immune response mediated by circulating immunoglobulin" NARROW []
is_a: GO:0002890 ! negative regulation of immunoglobulin mediated immune response
is_a: GO:0002921 ! negative regulation of humoral immune response
is_a: GO:0002923 ! regulation of humoral immune response mediated by circulating immunoglobulin
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002455 ! humoral immune response mediated by circulating immunoglobulin
relationship: negatively_regulates GO:0002455 ! humoral immune response mediated by circulating immunoglobulin

[Term]
id: GO:0002925
name: positive regulation of humoral immune response mediated by circulating immunoglobulin
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin." [GOC:add]
synonym: "activation of humoral immune response mediated by circulating immunoglobulin" NARROW []
synonym: "stimulation of humoral immune response mediated by circulating immunoglobulin" NARROW []
synonym: "up regulation of humoral immune response mediated by circulating immunoglobulin" EXACT []
synonym: "up-regulation of humoral immune response mediated by circulating immunoglobulin" EXACT []
synonym: "upregulation of humoral immune response mediated by circulating immunoglobulin" EXACT []
is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response
is_a: GO:0002922 ! positive regulation of humoral immune response
is_a: GO:0002923 ! regulation of humoral immune response mediated by circulating immunoglobulin
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002455 ! humoral immune response mediated by circulating immunoglobulin
relationship: positively_regulates GO:0002455 ! humoral immune response mediated by circulating immunoglobulin

[Term]
id: GO:0002926
name: tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridine biosynthesis.
namespace: biological_process
def: "The process whereby a wobble base uridine residue in a tRNA is modified to 5-methoxycarbonylmethyl-2-thiouridine." [GOC:hjd, UniPathway:UPA00988]
synonym: "mcm5s2U34 biosynthesis" EXACT []
is_a: GO:0002098 ! tRNA wobble uridine modification
created_by: hjd
creation_date: 2012-01-17T02:50:54Z

[Term]
id: GO:0002927
name: archaeosine-tRNA biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways involved in the biosynthesis of archaeosine, an archaea-specific modified base found at position 15 in the D-loop of certain archaeal tRNAs." [GOC:hjd, UniPathway:UPA00393]
comment: Archaeosine (7-formamidino-7-deazaguanosine) is a structural variant of the hypermodified nucleoside 7-deazaguanosine. The biosynthesis pathway starts with archaeosine tRNA-guanine transglycosylase (ArcTGT) which catalyzes the exchange of guanine at position 15 in the D-loop of archaeal tRNAs with a free 7-cyano-7-deazaguanine.
is_a: GO:0006400 ! tRNA modification
is_a: GO:0009058 ! biosynthetic process
relationship: has_part GO:0002948 ! archaeosine synthase activity
relationship: has_part GO:0043867 ! 7-cyano-7-deazaguanine tRNA-ribosyltransferase activity
created_by: hjd
creation_date: 2012-01-18T03:06:27Z

[Term]
id: GO:0002929
name: MECO complex
namespace: cellular_component
def: "A highly stable complex composed of the ATAC complex and the mediator complex (also called TRAP or MED). MECO binds and regulates the transcription of a subset of non-coding RNAs transcribed by RNA polymerase II." [GOC:hjd, PMID:20508642]
synonym: "meta-coactivator complex" EXACT []
is_a: GO:0043234 ! protein complex
relationship: has_part GO:0005671 ! Ada2/Gcn5/Ada3 transcription activator complex
relationship: has_part GO:0016592 ! mediator complex
created_by: hjd
creation_date: 2012-03-14T02:50:13Z

[Term]
id: GO:0002930
name: trabecular meshwork development
namespace: biological_process
def: "The progression of the trabecular meshwork over time, from its formation to the mature structure. The trabecular meshwork is a fenestrated endothelial-like tissue situated at the intersection of the cornea and the iris. The trabecular meshwork provides drainage for the aqueous humor." [PMID:20568247]
is_a: GO:0009888 ! tissue development
relationship: part_of GO:0043010 ! camera-type eye development
created_by: hjd
creation_date: 2012-04-19T04:50:06Z

[Term]
id: GO:0002931
name: response to ischemia
namespace: biological_process
def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply." [GOC:hjd]
comment: Ischemia always results in hypoxia; however, hypoxia can occur without ischemia .
is_a: GO:0006950 ! response to stress
created_by: hjd
creation_date: 2012-04-20T02:57:51Z

[Term]
id: GO:0002932
name: tendon sheath development
namespace: biological_process
def: "The process whose specific outcome is the progression of a tendon sheath over time, from its formation to the mature structure. A tendon sheath is a layer of membrane around a tendon. It permits the tendon to move." [PMID:20696843]
is_a: GO:0061448 ! connective tissue development
relationship: part_of GO:0035989 ! tendon development
created_by: hjd
creation_date: 2012-04-23T02:11:22Z

[Term]
id: GO:0002933
name: lipid hydroxylation
namespace: biological_process
def: "The covalent attachment of a hydroxyl group to one or more fatty acids in a lipid." [GOC:hjd, PMID:15658937]
synonym: "fatty acid hydroxylation" RELATED []
is_a: GO:0030258 ! lipid modification
created_by: hjd
creation_date: 2012-04-24T02:26:33Z

[Term]
id: GO:0002934
name: desmosome organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm." [GOC:hjd]
is_a: GO:0045216 ! cell-cell junction organization
created_by: hjd
creation_date: 2012-05-08T02:59:08Z

[Term]
id: GO:0002935
name: tRNA (adenine-C2-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + adenine(37) in tRNA = S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + C2-methyladenine(37) in a tRNA." [PMID:22891362]
is_a: GO:0008169 ! C-methyltransferase activity
is_a: GO:0016426 ! tRNA (adenine) methyltransferase activity
created_by: hjd
creation_date: 2012-09-04T14:39:56Z

[Term]
id: GO:0002936
name: bradykinin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the peptide hormone bradykinin." [PMID:11226291]
is_a: GO:0043043 ! peptide biosynthetic process
created_by: hjd
creation_date: 2012-10-17T14:24:24Z

[Term]
id: GO:0002937
name: tRNA 4-thiouridine biosynthesis
namespace: biological_process
def: "The processes whereby a uridine residue in a tRNA is converted to 4-thiouridine. Typically 4-thiouridine is found at position 8, in many transfer RNAs." [ISBN:155581073X]
comment: In E. coli, two genes are involved, nuvA (aka Thi) and NuvC (aka iscS) . NuvA converts the trNA into an unidentified intermediate in an ATP dependent manner. NucC catalyzes the second step, transferring the sulfur from cysteine to he unidentified intermediate. NuvC also participate sin thiamine synthesis.
is_a: GO:0034227 ! tRNA thio-modification
created_by: hjd
creation_date: 2012-10-19T15:26:28Z

[Term]
id: GO:0002938
name: tRNA guanine ribose methylation
namespace: biological_process
def: "The process whereby a guanosine residue in a tRNA is methylated on the 2'-hydroxyl group of the ribose moiety." [ISBN:155581075X, ISBN:1555811337]
is_a: GO:0002128 ! tRNA nucleoside ribose methylation
created_by: hjd
creation_date: 2012-11-02T15:55:55Z

[Term]
id: GO:0002939
name: tRNA N1-guanine methylation
namespace: biological_process
def: "The process whereby a guanine in tRNA is methylated at position N1 of the guanine." [ISBN:155581073X, ISBN:1555811337]
synonym: "tRNA m1-guanine biosynthesis" RELATED []
is_a: GO:0030488 ! tRNA methylation
created_by: hjd
creation_date: 2012-11-09T16:18:41Z

[Term]
id: GO:0002940
name: tRNA N2-guanine methylation
namespace: biological_process
def: "The process whereby a guanine in a tRNA is methylated at the N2 position of guanine." [ISBN:155581073X, ISBN:1555811337]
synonym: "tRNA m2-guanine biosynthesis" RELATED []
is_a: GO:0030488 ! tRNA methylation
created_by: hjd
creation_date: 2012-11-09T16:23:41Z

[Term]
id: GO:0002941
name: synoviocyte proliferation
namespace: biological_process
def: "The multiplication or reproduction of synoviocytes by cell division, resulting in the expansion of their population. A synoviocyte is a fibroblast-like cell found in synovial tissues." [CL:0000214, PMID:9546370]
is_a: GO:0008283 ! cell proliferation
created_by: hjd
creation_date: 2012-11-16T14:25:45Z

[Term]
id: GO:0002942
name: tRNA m2,2-guanine biosynthesis
namespace: biological_process
def: "The process whereby a guanine residue in a transfer RNA is methylated twice at the N2 position." [GOC:hjd, ISBN:1-55581-073-x]
is_a: GO:0030488 ! tRNA methylation
created_by: hjd
creation_date: 2012-11-16T16:07:20Z

[Term]
id: GO:0002943
name: tRNA dihydrouridine synthesis
namespace: biological_process
def: "The process whereby a uridine in a transfer RNA is converted to dihydrouridine." [GOC:hjd, ISBN:1-55581-073-x]
comment: Dihydrouridine is found in numerous positions within loop I, the so called dihydrouridine loop, of many transfer RNAs. Most often found at positions 16 and 17, but also sometimes at positions 20, 20a, and 20b.
is_a: GO:0006400 ! tRNA modification
created_by: hjd
creation_date: 2012-11-16T16:20:37Z

[Term]
id: GO:0002944
name: cyclin K-CDK12 complex
namespace: cellular_component
def: "A protein complex consisting of cyclin Kand cyclin-dependent kinase 12 (CDK12). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [PMID:22012619]
synonym: "CycK/Cdk12 complex" RELATED []
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex
created_by: hjd
creation_date: 2012-12-05T16:09:48Z

[Term]
id: GO:0002945
name: cyclin K-CDK13 complex
namespace: cellular_component
def: "A protein complex consisting of cyclin Kand cyclin-dependent kinase 13 (CDK13). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [PMID:22012619]
synonym: "CycK/Cdk13 complex" RELATED []
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex
created_by: hjd
creation_date: 2012-12-05T16:13:28Z

[Term]
id: GO:0002946
name: tRNA C5-cytosine methylation
namespace: biological_process
def: "The process whereby a cytosine in a tRNA is methylated at position 5 of the cytosine." [ISBN:1-55581-073-x]
synonym: "tRNA 5-methylcytosine biosynthesis" RELATED []
is_a: GO:0030488 ! tRNA methylation
created_by: hjd
creation_date: 2012-12-07T14:23:13Z

[Term]
id: GO:0002947
name: tumor necrosis factor receptor superfamily complex
namespace: cellular_component
def: "A receptor complex that contains one or more members of the tumor necrosis factor (TNF) receptor superfamily." [GOC:krc]
synonym: "TNF receptor superfamily complex" RELATED []
is_a: GO:0043235 ! receptor complex
created_by: hjd
creation_date: 2012-12-20T13:26:39Z

[Term]
id: GO:0002948
name: archaeosine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamine + 7-cyano-7-carbaguanine15 in tRNA + H2O = L-glutamate + archaeine15 in tRNA." [PMID:20129918, Wikipedia:Archaeosine_synthase]
synonym: "ArcS" RELATED []
synonym: "glutamine:preQ0-tRNA amidinotransferase" RELATED []
xref: EC:2.6.1.97
is_a: GO:0015067 ! amidinotransferase activity
created_by: hjd
creation_date: 2014-08-11T10:33:59Z

[Term]
id: GO:0002949
name: tRNA threonylcarbamoyladenosine modification
namespace: biological_process
alt_id: GO:0070526
def: "The attachment of a carbonyl group and a threonine to the amino group of the adenine residue immediately 3' of the anticodon, in tRNAs that decode ANN codons (where N is any base)." [GO:0070526, GOC:imk, GOC:mah, PMID:19287007, PMID:21183954, PMID:23258706]
synonym: "t6A biosynthesis" EXACT [PMID:19287007]
synonym: "t6A biosynthetic process" EXACT [PMID:19287007]
synonym: "t6A tRNA modification" EXACT []
synonym: "threonylcarbamoyladenosine anabolism" EXACT [GOC:mah]
synonym: "threonylcarbamoyladenosine biosynthesis" EXACT [GOC:mah]
synonym: "threonylcarbamoyladenosine biosynthetic process" EXACT []
synonym: "threonylcarbamoyladenosine formation" EXACT [GOC:mah]
synonym: "threonylcarbamoyladenosine synthesis" EXACT [GOC:mah]
is_a: GO:0006400 ! tRNA modification
is_a: GO:0070525 ! tRNA threonylcarbamoyladenosine metabolic process
created_by: hjd
creation_date: 2014-09-19T10:15:27Z

[Term]
id: GO:0003001
name: obsolete generation of a signal involved in cell-cell signaling
namespace: biological_process
def: "The cellular process that creates a physical entity or change in state, i.e. a signal, that originates in one cell and is used to transfer information to another cell. This process begins with the initial formation of the signal and ends with the mature form and placement of the signal." [GOC:dph]
comment: This term was made obsolete because biosynthesis of a signal occurs before the start of cell-cell signaling.
synonym: "formation of a signal" BROAD []
synonym: "generation of a signal involved in cell-cell signaling" EXACT []
synonym: "generation of a signal involved in cell-cell signalling" EXACT []
synonym: "signal generation" BROAD []
is_obsolete: true
consider: GO:0007267
consider: GO:0010496
consider: GO:0023061
consider: GO:0031130

[Term]
id: GO:0003002
name: regionalization
namespace: biological_process
def: "The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment." [GOC:dph, GOC:isa_complete]
synonym: "pattern formation" RELATED [GOC:dph]
is_a: GO:0007389 ! pattern specification process

[Term]
id: GO:0003003
name: follicular fluid formation in ovarian follicle antrum involved in fused antrum stage
namespace: biological_process
def: "The ovulation cycle process in which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed as part of the fused antrum stage of oogenesis." [GOC:dph, GOC:isa_complete]
synonym: "follicular fluid formation in ovarian follicle antrum during fused antrum stage" RELATED [GOC:dph, GOC:tb]
is_a: GO:0001548 ! follicular fluid formation in ovarian follicle antrum
intersection_of: GO:0001548 ! follicular fluid formation in ovarian follicle antrum
intersection_of: part_of GO:0048165 ! fused antrum stage
relationship: part_of GO:0048165 ! fused antrum stage

[Term]
id: GO:0003004
name: follicular fluid formation in ovarian follicle antrum involved in distinct antral spaces stage
namespace: biological_process
def: "The menstrual cycle process in which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed as part of the antral spaces stage of oogenesis." [GOC:dph, GOC:isa_complete]
synonym: "follicular fluid formation in ovarian follicle antrum during distinct antral spaces stage" RELATED [GOC:dph, GOC:tb]
is_a: GO:0001548 ! follicular fluid formation in ovarian follicle antrum
intersection_of: GO:0001548 ! follicular fluid formation in ovarian follicle antrum
intersection_of: part_of GO:0048164 ! distinct antral spaces stage
relationship: part_of GO:0048164 ! distinct antral spaces stage

[Term]
id: GO:0003005
name: follicular fluid formation in ovarian follicle antrum involved in scattered antral spaces stage
namespace: biological_process
def: "The menstrual cycle process in which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed as part of the scattered antral spaces stage of oogenesis." [GOC:dph, GOC:isa_complete]
synonym: "follicular fluid formation in ovarian follicle antrum during scattered antral spaces stage" RELATED [GOC:dph, GOC:tb]
is_a: GO:0001548 ! follicular fluid formation in ovarian follicle antrum
intersection_of: GO:0001548 ! follicular fluid formation in ovarian follicle antrum
intersection_of: part_of GO:0048163 ! scattered antral spaces stage
relationship: part_of GO:0048163 ! scattered antral spaces stage

[Term]
id: GO:0003006
name: developmental process involved in reproduction
namespace: biological_process
def: "A developmental process in which a progressive change in the state of some part of an organism specifically contributes to its ability to form offspring." [GOC:dph, GOC:isa_complete]
synonym: "puberty" NARROW [GOC:dph]
synonym: "reproductive developmental process" RELATED [GOC:dph, GOC:tb]
is_a: GO:0022414 ! reproductive process
is_a: GO:0032502 ! developmental process
intersection_of: GO:0032502 ! developmental process
intersection_of: part_of GO:0000003 ! reproduction
relationship: part_of GO:0000003 ! reproduction

[Term]
id: GO:0003007
name: heart morphogenesis
namespace: biological_process
def: "The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:dph, GOC:isa_complete]
synonym: "cardiac morphogenesis" RELATED []
is_a: GO:0009887 ! organ morphogenesis
relationship: part_of GO:0007507 ! heart development

[Term]
id: GO:0003008
name: system process
namespace: biological_process
def: "A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective." [GOC:mtg_cardio]
synonym: "organ system process" EXACT []
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0003009
name: skeletal muscle contraction
namespace: biological_process
def: "A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control." [GOC:mtg_cardio, GOC:mtg_muscle]
is_a: GO:0006941 ! striated muscle contraction
relationship: part_of GO:0050881 ! musculoskeletal movement

[Term]
id: GO:0003010
name: voluntary skeletal muscle contraction
namespace: biological_process
def: "A process in which force is generated within voluntary skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the voluntary skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and it is under voluntary control. Voluntary skeletal muscle is skeletal muscle that is under conscious control." [GOC:mtg_cardio, GOC:mtg_muscle]
is_a: GO:0003009 ! skeletal muscle contraction

[Term]
id: GO:0003011
name: involuntary skeletal muscle contraction
namespace: biological_process
def: "A process in which force is generated within involuntary skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Involuntary skeletal muscle is skeletal muscle that is not under conscious control." [GOC:mtg_cardio, GOC:mtg_muscle]
is_a: GO:0003009 ! skeletal muscle contraction

[Term]
id: GO:0003012
name: muscle system process
namespace: biological_process
def: "A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers." [GOC:mtg_cardio]
synonym: "muscle physiological process" RELATED []
is_a: GO:0003008 ! system process

[Term]
id: GO:0003013
name: circulatory system process
namespace: biological_process
def: "A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism." [GOC:mtg_cardio]
subset: goslim_chembl
subset: goslim_generic
xref: Wikipedia:Circulatory_system
is_a: GO:0003008 ! system process

[Term]
id: GO:0003014
name: renal system process
namespace: biological_process
def: "A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila)." [GOC:cjm, GOC:mtg_cardio, GOC:mtg_kidney_jan10]
synonym: "excretory system process" EXACT []
synonym: "kidney system process" RELATED []
is_a: GO:0003008 ! system process

[Term]
id: GO:0003015
name: heart process
namespace: biological_process
def: "A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:mtg_cardio]
synonym: "cardiac process" RELATED []
is_a: GO:0003013 ! circulatory system process

[Term]
id: GO:0003016
name: respiratory system process
namespace: biological_process
alt_id: GO:0010802
def: "A system process carried out by the organs and tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange." [GOC:dph, GOC:mtg_cardio, GOC:tb]
synonym: "respiratory gaseous exchange by respiratory system" EXACT []
is_a: GO:0003008 ! system process
is_a: GO:0007585 ! respiratory gaseous exchange

[Term]
id: GO:0003017
name: lymph circulation
namespace: biological_process
def: "The flow of lymph through the body of an animal." [GOC:mtg_cardio]
is_a: GO:0003013 ! circulatory system process

[Term]
id: GO:0003018
name: vascular process in circulatory system
namespace: biological_process
def: "A circulatory process that occurs at the level of the vasculature." [GOC:mtg_cardio]
synonym: "vasculature process" EXACT []
is_a: GO:0003013 ! circulatory system process

[Term]
id: GO:0003019
name: central nervous system control of baroreceptor feedback
namespace: biological_process
def: "The neurological process in which nerve impulses arising in the aorta or the carotid sinuses travel to the medulla and reach the nucleus of tractus solaris." [GOC:mtg_cardio, ISBN:0323031951]
is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure
relationship: part_of GO:0001978 ! regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback

[Term]
id: GO:0003020
name: detection of reduced oxygen by chemoreceptor signaling
namespace: biological_process
def: "The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies." [GOC:mtg_cardio, ISBN:0323031951]
synonym: "detection of reduced oxygen by chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0070483 ! detection of hypoxia
relationship: part_of GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptor signaling

[Term]
id: GO:0003021
name: detection of increased carbon dioxide by chemoreceptor signaling
namespace: biological_process
def: "The process in which information about the levels of carbon dioxide are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies." [GOC:mtg_cardio, ISBN:0323031951]
synonym: "detection of increased carbon dioxide by chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0003031 ! detection of carbon dioxide
relationship: part_of GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptor signaling

[Term]
id: GO:0003022
name: detection of pH by chemoreceptor signaling
namespace: biological_process
def: "The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors." [GOC:mtg_cardio, ISBN:0323031951]
synonym: "detection of pH by chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0003030 ! detection of hydrogen ion

[Term]
id: GO:0003023
name: baroreceptor detection of increased arterial stretch
namespace: biological_process
def: "The series of events by which an increase in diameter of an artery is detected and converted to a molecular signal." [GOC:mtg_cardio]
is_a: GO:0001981 ! baroreceptor detection of arterial stretch
relationship: part_of GO:0001983 ! baroreceptor response to increased systemic arterial blood pressure

[Term]
id: GO:0003024
name: baroreceptor detection of decreased arterial stretch
namespace: biological_process
def: "The series of events by which a decrease in diameter of an artery is detected and converted to a molecular signal." [GOC:mtg_cardio]
is_a: GO:0001981 ! baroreceptor detection of arterial stretch
relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure

[Term]
id: GO:0003025
name: regulation of systemic arterial blood pressure by baroreceptor feedback
namespace: biological_process
def: "The neural regulation of blood pressure in which baroreceptors sense the amount of stretch occurring in vessels and respond to the input via central nervous system control." [GOC:dph, GOC:mtg_cardio, GOC:tb]
synonym: "baroreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb]
is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure

[Term]
id: GO:0003026
name: regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback
namespace: biological_process
def: "The process that modulates blood pressure by sensing the amount of stretch occurring in the aorta and responding to the input via central nervous system control." [GOC:dph, GOC:mtg_cardio, GOC:tb]
synonym: "aortic arch baroreceptor control of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb]
is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure
relationship: part_of GO:0003025 ! regulation of systemic arterial blood pressure by baroreceptor feedback

[Term]
id: GO:0003027
name: regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling
namespace: biological_process
def: "The process that modulates blood pressure by the action of chemoreceptors found in the carotid bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions." [GOC:dph, GOC:mtg_cardio, GOC:tb]
synonym: "carotid body chemoreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb]
synonym: "carotid body chemoreceptor response to lowering of systemic arterial blood pressure" EXACT [GOC:dph]
synonym: "regulation of systemic arterial blood pressure by carotid body chemoreceptor signalling" EXACT [GOC:mah]
synonym: "vagal reflex" BROAD []
is_a: GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling

[Term]
id: GO:0003028
name: regulation of systemic arterial blood pressure by aortic body chemoreceptor signaling
namespace: biological_process
def: "The process that modulates blood pressure by the action of chemoreceptors found in the aortic bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions." [GOC:dph, GOC:mtg_cardio, GOC:tb]
synonym: "aortic body chemoreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb]
synonym: "aortic body chemoreceptor response to lowering of systemic arterial blood pressure" EXACT [GOC:dph]
synonym: "regulation of systemic arterial blood pressure by aortic body chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling

[Term]
id: GO:0003029
name: detection of hypoxic conditions in blood by carotid body chemoreceptor signaling
namespace: biological_process
def: "The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies." [GOC:mtg_cardio]
synonym: "detection of hypoxic conditions in blood by carotid body chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptor signaling
relationship: part_of GO:0003027 ! regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling

[Term]
id: GO:0003030
name: detection of hydrogen ion
namespace: biological_process
def: "The series of events in which a hydrogen ion stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_cardio]
is_a: GO:0009593 ! detection of chemical stimulus

[Term]
id: GO:0003031
name: detection of carbon dioxide
namespace: biological_process
def: "The series of events in which a carbon dioxide stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_cardio]
is_a: GO:0009593 ! detection of chemical stimulus

[Term]
id: GO:0003032
name: detection of oxygen
namespace: biological_process
def: "The series of events in which an oxygen stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_cardio]
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0070482 ! response to oxygen levels

[Term]
id: GO:0003033
name: detection of hypoxic conditions in blood by aortic body chemoreceptor signaling
namespace: biological_process
def: "The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the aortic bodies." [GOC:mtg_cardio]
synonym: "detection of hypoxic conditions in blood by aortic body chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptor signaling
relationship: part_of GO:0003028 ! regulation of systemic arterial blood pressure by aortic body chemoreceptor signaling

[Term]
id: GO:0003034
name: detection of increased carbon dioxide by aortic body chemoreceptor signaling
namespace: biological_process
def: "The process in which information about the levels of carbon dioxide are received and are converted to a molecular signal by chemoreceptors in an aortic body." [GOC:mtg_cardio]
synonym: "detection of increased carbon dioxide by aortic body chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0003021 ! detection of increased carbon dioxide by chemoreceptor signaling
relationship: part_of GO:0003033 ! detection of hypoxic conditions in blood by aortic body chemoreceptor signaling

[Term]
id: GO:0003035
name: detection of increased carbon dioxide by carotid body chemoreceptor signaling
namespace: biological_process
def: "The process in which information about the levels of carbon dioxide are received and are converted to a molecular signal by chemoreceptors in a carotid body." [GOC:mtg_cardio]
synonym: "detection of increased carbon dioxide by carotid body chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0003021 ! detection of increased carbon dioxide by chemoreceptor signaling
relationship: part_of GO:0003029 ! detection of hypoxic conditions in blood by carotid body chemoreceptor signaling

[Term]
id: GO:0003036
name: detection of pH by aortic body chemoreceptor signaling
namespace: biological_process
def: "The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors in an aortic body." [GOC:mtg_cardio]
synonym: "detection of pH by aortic body chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0003022 ! detection of pH by chemoreceptor signaling
relationship: part_of GO:0003033 ! detection of hypoxic conditions in blood by aortic body chemoreceptor signaling

[Term]
id: GO:0003037
name: detection of pH by carotid body chemoreceptor signaling
namespace: biological_process
def: "The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors in a carotid body." [GOC:mtg_cardio]
synonym: "detection of pH by carotid body chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0003022 ! detection of pH by chemoreceptor signaling
relationship: part_of GO:0003029 ! detection of hypoxic conditions in blood by carotid body chemoreceptor signaling

[Term]
id: GO:0003038
name: detection of reduced oxygen by aortic body chemoreceptor signaling
namespace: biological_process
def: "The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in an aortic body." [GOC:mtg_cardio]
synonym: "detection of reduced oxygen by aortic body chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0003020 ! detection of reduced oxygen by chemoreceptor signaling
relationship: part_of GO:0003033 ! detection of hypoxic conditions in blood by aortic body chemoreceptor signaling

[Term]
id: GO:0003039
name: detection of reduced oxygen by carotid body chemoreceptor signaling
namespace: biological_process
def: "The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in a carotid body." [GOC:mtg_cardio]
synonym: "detection of reduced oxygen by carotid body chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0003020 ! detection of reduced oxygen by chemoreceptor signaling
relationship: part_of GO:0003029 ! detection of hypoxic conditions in blood by carotid body chemoreceptor signaling

[Term]
id: GO:0003040
name: excitation of vasomotor center by aortic body chemoreceptor signaling
namespace: biological_process
def: "The process in which the molecular signal from an aortic body is relayed to the vasomotor center, causing it to signal an increase arterial pressure." [GOC:mtg_cardio]
synonym: "excitation of vasomotor center by aortic body chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0002008 ! excitation of vasomotor center by chemoreceptor signaling
relationship: part_of GO:0003028 ! regulation of systemic arterial blood pressure by aortic body chemoreceptor signaling

[Term]
id: GO:0003041
name: excitation of vasomotor center by carotid body chemoreceptor signaling
namespace: biological_process
def: "The process in which the molecular signal from a carotid body is relayed to the vasomotor center, causing it to signal an increase arterial pressure." [GOC:mtg_cardio]
synonym: "excitation of vasomotor center by carotid body chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0002008 ! excitation of vasomotor center by chemoreceptor signaling
relationship: part_of GO:0003027 ! regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling

[Term]
id: GO:0003042
name: vasoconstriction of artery involved in carotid body chemoreceptor response to lowering of systemic arterial blood pressure
namespace: biological_process
def: "A process that is triggered by carotid body-vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure." [ISBN:0323031951]
synonym: "vasoconstriction of artery during carotid body chemoreceptor response to lowering of systemic arterial blood pressure" RELATED [GOC:dph]
is_a: GO:0002012 ! vasoconstriction of artery involved in chemoreceptor response to lowering of systemic arterial blood pressure
relationship: part_of GO:0003027 ! regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling

[Term]
id: GO:0003043
name: vasoconstriction of artery involved in aortic body chemoreceptor response to lowering of systemic arterial blood pressure
namespace: biological_process
def: "A process that is triggered by aortic body-vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure." [GOC:mtg_cardio]
synonym: "vasoconstriction of artery during aortic body chemoreceptor response to lowering of systemic arterial blood pressure" RELATED [GOC:dph]
is_a: GO:0002012 ! vasoconstriction of artery involved in chemoreceptor response to lowering of systemic arterial blood pressure
relationship: part_of GO:0003028 ! regulation of systemic arterial blood pressure by aortic body chemoreceptor signaling

[Term]
id: GO:0003044
name: regulation of systemic arterial blood pressure mediated by a chemical signal
namespace: biological_process
def: "The regulation of blood pressure mediated by biochemical signaling: hormonal, autocrine or paracrine." [GOC:mtg_cardio]
synonym: "blood pressure regulation mediated by a chemical signal" EXACT []
is_a: GO:0003073 ! regulation of systemic arterial blood pressure

[Term]
id: GO:0003045
name: regulation of systemic arterial blood pressure by physical factors
namespace: biological_process
def: "The regulation of blood pressure mediated by detection of forces within the circulatory system." [GOC:mtg_cardio]
synonym: "blood pressure regulation by physical factors" EXACT []
is_a: GO:0003073 ! regulation of systemic arterial blood pressure

[Term]
id: GO:0003046
name: regulation of systemic arterial blood pressure by stress relaxation
namespace: biological_process
def: "The intrinsic circulatory process resulting from stress relaxation that modulates the force with which blood travels through the systemic arterial circulatory system. Stress relaxation is the adaptation of vessels to a new size as a result of changes in pressure in storage areas such as veins, the liver, the spleen, and the lungs." [GOC:mtg_cardio, ISBN:0721643949]
synonym: "blood pressure regulation by stress relaxation" EXACT []
is_a: GO:0003045 ! regulation of systemic arterial blood pressure by physical factors
is_a: GO:0003085 ! negative regulation of systemic arterial blood pressure

[Term]
id: GO:0003047
name: regulation of systemic arterial blood pressure by epinephrine
namespace: biological_process
def: "The regulation of blood pressure mediated by the catecholamine signaling molecule epinephrine." [GOC:mtg_cardio]
synonym: "blood pressure regulation by epinephrine" RELATED []
synonym: "regulation of blood pressure by adrenaline" EXACT []
is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal
relationship: part_of GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine

[Term]
id: GO:0003048
name: regulation of systemic arterial blood pressure by norepinephrine
namespace: biological_process
def: "The regulation of blood pressure mediated by the catecholamine signaling molecule norepinephrine." [GOC:mtg_cardio]
synonym: "blood pressure regulation by norepinephrine" RELATED []
synonym: "regulation of blood pressure by noradrenaline" EXACT []
is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal
relationship: part_of GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine

[Term]
id: GO:0003049
name: regulation of systemic arterial blood pressure by capillary fluid shift
namespace: biological_process
def: "The intrinsic circulatory process resulting from capillary fluid shift that modulates the force with which blood travels through the systemic arterial circulatory system. Capillary fluid shift is the movement of fluid across the capillary membrane between the blood and the interstitial fluid compartment." [GOC:mtg_cardio, ISBN:0721643949]
synonym: "blood pressure regulation by capillary fluid shift" EXACT []
is_a: GO:0003045 ! regulation of systemic arterial blood pressure by physical factors

[Term]
id: GO:0003050
name: regulation of systemic arterial blood pressure by atrial natriuretic peptide
namespace: biological_process
def: "The regulation of blood pressure mediated by the signaling molecule atrial natriuretic peptide." [GOC:mtg_cardio]
synonym: "blood pressure regulation by ANP" RELATED [GOC:mtg_cardio]
synonym: "blood pressure regulation by atrial natriuretic peptide" EXACT []
is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone

[Term]
id: GO:0003051
name: angiotensin-mediated drinking behavior
namespace: biological_process
def: "The drinking behavior that is mediated by the action of angiotensin in the brain. Angiotensin stimulates the brain centers that control thirst." [GOC:mtg_cardio]
synonym: "angiotensin mediated drinking behavior" EXACT [GOC:dph, GOC:tb]
is_a: GO:0042756 ! drinking behavior
relationship: part_of GO:0002035 ! brain renin-angiotensin system

[Term]
id: GO:0003052
name: circadian regulation of systemic arterial blood pressure
namespace: biological_process
def: "Any process in which an organism modulates its blood pressure at different values with a regularity of approximately 24 hours." [GOC:mtg_cardio, GOC:rl]
is_a: GO:0003073 ! regulation of systemic arterial blood pressure
is_a: GO:0007623 ! circadian rhythm

[Term]
id: GO:0003053
name: circadian regulation of heart rate
namespace: biological_process
def: "Any process in which an organism modulates its heart rate at different values with a regularity of approximately 24 hours." [GOC:mtg_cardio, GOC:rl]
synonym: "circadian regulation of heart contraction rate" RELATED []
is_a: GO:0002027 ! regulation of heart rate
is_a: GO:0007623 ! circadian rhythm
is_a: GO:0044707 ! single-multicellular organism process

[Term]
id: GO:0003054
name: circadian regulation of systemic arterial blood pressure by the suprachiasmatic nucleus
namespace: biological_process
def: "The process in which the suprachiasmatic nucleus modulates blood pressure at different values with a regularity of approximately 24 hours." [GOC:mtg_cardio, GOC:rl]
synonym: "master pacemaker clock regulation of blood pressure" EXACT []
synonym: "SCN regulation of blood pressure" EXACT []
is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure
is_a: GO:0003052 ! circadian regulation of systemic arterial blood pressure

[Term]
id: GO:0003055
name: circadian regulation of heart rate by the suprachiasmatic nucleus
namespace: biological_process
def: "The process in which the suprachiasmatic nucleus modulates heart rate at different values with a regularity of approximately 24 hours." [GOC:mtg_cardio, GOC:rl]
synonym: "circadian regulation of heart contraction rate by the suprachiasmatic nucleus" RELATED []
synonym: "master pacemaker clock regulation of heart rate" EXACT []
synonym: "SCN regulation of heart rate" EXACT []
is_a: GO:0003053 ! circadian regulation of heart rate

[Term]
id: GO:0003056
name: regulation of vascular smooth muscle contraction
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of vascular smooth muscle contraction." [GOC:mtg_cardio, GOC:mtg_sensu, GOC:rl]
is_a: GO:0006940 ! regulation of smooth muscle contraction
is_a: GO:0019229 ! regulation of vasoconstriction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0014829 ! vascular smooth muscle contraction
relationship: regulates GO:0014829 ! vascular smooth muscle contraction

[Term]
id: GO:0003057
name: regulation of the force of heart contraction by chemical signal
namespace: biological_process
def: "The regulation of the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine." [GOC:mtg_cardio, GOC:rl]
synonym: "chemical cardiac inotropy" EXACT []
synonym: "regulation of the force of heart muscle contraction by chemical signal" RELATED []
is_a: GO:0002026 ! regulation of the force of heart contraction

[Term]
id: GO:0003058
name: hormonal regulation of the force of heart contraction
namespace: biological_process
def: "The process in which the hormones modulates the force of heart muscle contraction. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." [GOC:mtg_cardio, GOC:rl]
synonym: "hormonal cardiac inotropy" EXACT []
synonym: "hormonal regulation of the force of heart muscle contraction" RELATED []
is_a: GO:0003057 ! regulation of the force of heart contraction by chemical signal

[Term]
id: GO:0003059
name: positive regulation of the force of heart contraction by epinephrine
namespace: biological_process
def: "The process in which the secretion of epinephrine into the bloodstream or released from nerve endings modulates the force of heart muscle contraction." [GOC:mtg_cardio, GOC:rl]
synonym: "adrenaline cardiac inotropy" EXACT []
synonym: "adrenaline regulation of the strength of heart muscle contraction" EXACT []
synonym: "epinephrine cardiac inotropy" EXACT []
synonym: "increased force of heart contraction by epinephrine" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of heart contraction by adrenaline" RELATED []
synonym: "positive regulation of heart contraction by epinephrine" RELATED []
is_a: GO:0003099 ! positive regulation of the force of heart contraction by chemical signal
relationship: part_of GO:0001997 ! positive regulation of the force of heart contraction by epinephrine-norepinephrine

[Term]
id: GO:0003060
name: negative regulation of the force of heart contraction by acetylcholine
namespace: biological_process
def: "The process in which acetylcholine released from vagus nerve endings binds to muscarinic receptors and decreases the force of heart muscle contraction." [GOC:mtg_cardio, GOC:rl]
synonym: "decreased force of heart contraction by acetylcholine" EXACT []
is_a: GO:0003108 ! negative regulation of the force of heart contraction by chemical signal
relationship: part_of GO:0003068 ! regulation of systemic arterial blood pressure by acetylcholine

[Term]
id: GO:0003061
name: positive regulation of the force of heart contraction by norepinephrine
namespace: biological_process
def: "The process in which the secretion of norepinephrine into the bloodstream or released from nerve endings modulates the force of heart musclecontraction." [GOC:mtg_cardio, GOC:rl]
synonym: "increased force of heart contraction by adrenaline" RELATED []
synonym: "increased force of heart contraction by norepinephrine" EXACT []
synonym: "noradrenaline cardiac inotropy" EXACT []
synonym: "noradrenaline regulation of the strength of heart muscle contraction" EXACT []
synonym: "norepinephrine cardiac inotropy" EXACT []
synonym: "positive regulation of heart contraction by adrenaline" RELATED []
synonym: "positive regulation of heart contraction by norepinephrine" RELATED []
is_a: GO:0003099 ! positive regulation of the force of heart contraction by chemical signal
relationship: part_of GO:0001997 ! positive regulation of the force of heart contraction by epinephrine-norepinephrine

[Term]
id: GO:0003062
name: regulation of heart rate by chemical signal
namespace: biological_process
def: "The regulation of the rate of heart contraction mediated by chemical signaling, hormonal, autocrine or paracrine." [GOC:dph, GOC:mtg_cardio, GOC:rl, GOC:tb]
synonym: "chemical cardiac chronotropy" EXACT []
synonym: "chemical signal regulation of heart contraction rate" RELATED []
synonym: "chemical signal regulation of heart rate" EXACT [GOC:dph, GOC:tb]
is_a: GO:0002027 ! regulation of heart rate

[Term]
id: GO:0003063
name: negative regulation of heart rate by acetylcholine
namespace: biological_process
def: "The process in which acetylcholine released from vagus nerve endings binds to muscarinic receptors on the pacemaker cells and decreases the rate of heart muscle contraction." [GOC:mtg_cardio, GOC:rl]
synonym: "negative regulation of heart contraction rate by acetylcholine" RELATED []
is_a: GO:0003062 ! regulation of heart rate by chemical signal
is_a: GO:0010459 ! negative regulation of heart rate
relationship: part_of GO:0003068 ! regulation of systemic arterial blood pressure by acetylcholine

[Term]
id: GO:0003064
name: regulation of heart rate by hormone
namespace: biological_process
def: "The process in which the hormones modulates the rate of heart muscle contraction. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." [GOC:mtg_cardio, GOC:rl]
synonym: "hormonal cardiac chronotropy" EXACT []
synonym: "regulation of the rate of heart contraction by hormone" EXACT [GOC:curators]
is_a: GO:0003062 ! regulation of heart rate by chemical signal

[Term]
id: GO:0003065
name: positive regulation of heart rate by epinephrine
namespace: biological_process
def: "The process in which the secretion of epinephrine into the bloodstream or released from nerve endings increases the rate of heart muscle contraction." [GOC:mtg_cardio, GOC:rl]
synonym: "adrenaline cardiac chronotropy" EXACT []
synonym: "adrenaline regulation of the rate of heart muscle contraction" EXACT []
synonym: "epinephrine cardiac chronotropy" EXACT []
synonym: "positive regulation of heart contraction rate by epinephrine" RELATED []
synonym: "positive regulation of heart rate by adrenaline" RELATED []
is_a: GO:0003062 ! regulation of heart rate by chemical signal
is_a: GO:0010460 ! positive regulation of heart rate
relationship: part_of GO:0001996 ! positive regulation of heart rate by epinephrine-norepinephrine

[Term]
id: GO:0003066
name: positive regulation of heart rate by norepinephrine
namespace: biological_process
def: "The process in which the secretion of norepinephrine into the bloodstream or released from nerve endings increases the rate of heart muscle contraction." [GOC:mtg_cardio, GOC:rl]
synonym: "noradrenaline cardiac chronotropy" EXACT []
synonym: "noradrenaline regulation of the rate of heart muscle contraction" EXACT []
synonym: "norepinephrine cardiac chronotropy" EXACT []
synonym: "positive regulation of heart contraction rate by norepinephrine" RELATED []
synonym: "positive regulation of heart rate by adrenaline" EXACT []
is_a: GO:0003062 ! regulation of heart rate by chemical signal
is_a: GO:0010460 ! positive regulation of heart rate
relationship: part_of GO:0001996 ! positive regulation of heart rate by epinephrine-norepinephrine

[Term]
id: GO:0003067
name: circadian regulation of systemic arterial blood pressure by hormone
namespace: biological_process
def: "The process in which hormones modulate the force with which blood passes through the circulatory system contributing to different values of blood pressure oscillating with a regularity of approximately 24 hours. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." [GOC:mtg_cardio]
is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone
relationship: part_of GO:0003052 ! circadian regulation of systemic arterial blood pressure

[Term]
id: GO:0003068
name: regulation of systemic arterial blood pressure by acetylcholine
namespace: biological_process
def: "The regulation of blood pressure mediated by acetylcholine signaling. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter." [GOC:mtg_cardio, GOC:rl]
synonym: "blood pressure regulation by acetylcholine" EXACT []
is_a: GO:0003070 ! regulation of systemic arterial blood pressure by neurotransmitter

[Term]
id: GO:0003069
name: vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure
namespace: biological_process
def: "The process in which acetylcholine signaling causes vasodilation, resulting in a change in blood pressure." [GOC:mtg_cardio, GOC:rl]
is_a: GO:0003085 ! negative regulation of systemic arterial blood pressure
is_a: GO:0042311 ! vasodilation
relationship: part_of GO:0003068 ! regulation of systemic arterial blood pressure by acetylcholine

[Term]
id: GO:0003070
name: regulation of systemic arterial blood pressure by neurotransmitter
namespace: biological_process
def: "The regulation of blood pressure mediated by a neurotransmitter. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell." [GOC:mtg_cardio]
is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure
is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal

[Term]
id: GO:0003071
name: renal system process involved in regulation of systemic arterial blood pressure
namespace: biological_process
def: "Renal process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure." [GOC:dph, GOC:mtg_cardio, GOC:tb]
synonym: "renal control of blood pressure" EXACT []
synonym: "renal regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb]
is_a: GO:0003014 ! renal system process
intersection_of: GO:0003014 ! renal system process
intersection_of: part_of GO:0003073 ! regulation of systemic arterial blood pressure
relationship: part_of GO:0003073 ! regulation of systemic arterial blood pressure

[Term]
id: GO:0003072
name: renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure
namespace: biological_process
def: "The renal process that modulates the force with which blood travels through the circulatory system, by impeding blood flow through the peripheral vasculature." [GOC:mtg_cardio]
synonym: "regulation of systemic arterial blood pressure by renal control of peripheral vascular resistence" EXACT [GOC:dph, GOC:tb]
synonym: "renal regulation of systemic arterial blood pressure by control of peripheral vascular resistence" EXACT [GOC:dph, GOC:tb]
is_a: GO:0003071 ! renal system process involved in regulation of systemic arterial blood pressure

[Term]
id: GO:0003073
name: regulation of systemic arterial blood pressure
namespace: biological_process
def: "The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure." [GOC:mtg_cardio]
is_a: GO:0008217 ! regulation of blood pressure

[Term]
id: GO:0003074
name: obsolete regulation of diuresis
namespace: biological_process
def: "OBSOLETE. Any process that modulates the rate of diuresis. Diuresis is the process of renal water excretion." [GOC:mtg_cardio]
comment: This term was made obsolete because its definition was inaccurate.
synonym: "regulation of diuresis" EXACT []
is_obsolete: true
consider: GO:0035809

[Term]
id: GO:0003075
name: renal vasodilation of the peripheral vascular system involved in regulation of systemic arterial blood pressure
namespace: biological_process
def: "The renal process that modulates the force with which blood travels through the circulatory system, by vasodilation of the peripheral vascular system." [GOC:mtg_cardio]
synonym: "renal regulation of systemic arterial blood pressure by vasodilation of the peripheral vascular system" EXACT [GOC:dph, GOC:tb]
is_a: GO:0003072 ! renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure

[Term]
id: GO:0003077
name: obsolete negative regulation of diuresis
namespace: biological_process
def: "OBSOLETE. Any process that reduces the rate of diuresis. Diuresis is the process of renal water excretion." [GOC:mtg_cardio]
comment: This term was made obsolete because its definition was inaccurate.
synonym: "negative regulation of diuresis" EXACT []
is_obsolete: true
consider: GO:0035811

[Term]
id: GO:0003078
name: obsolete regulation of natriuresis
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate, or extent of natriuresis, the process of renal sodium excretion." [GOC:mah]
comment: This term was made obsolete because its definition was inaccurate.
synonym: "regulation of natriuresis" EXACT []
is_obsolete: true
consider: GO:0035813

[Term]
id: GO:0003079
name: obsolete positive regulation of natriuresis
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of natriuresis." [GOC:mtg_cardio]
comment: This term was made obsolete because its definition was inaccurate.
synonym: "positive regulation of natriuresis" EXACT []
is_obsolete: true
consider: GO:0035815

[Term]
id: GO:0003080
name: obsolete negative regulation of natriuresis
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or decreases the frequency, rate, or extent of natriuresis, the process of renal sodium excretion." [GOC:mah]
comment: This term was made obsolete because its definition was inaccurate.
synonym: "negative regulation of natriuresis" EXACT []
is_obsolete: true
consider: GO:0035814

[Term]
id: GO:0003081
name: regulation of systemic arterial blood pressure by renin-angiotensin
namespace: biological_process
def: "The process in which renin-angiotensin modulates the force with which blood passes through the circulatory system." [GOC:mtg_cardio]
synonym: "blood pressure regulation by renin-angiotensin" EXACT []
is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone

[Term]
id: GO:0003082
name: obsolete positive regulation of renal output by angiotensin
namespace: biological_process
def: "OBSOLETE. Any process in which angiotensin directly increases the rate of natriuresis and diuresis in the kidney." [GOC:dph, GOC:mtg_cardio, GOC:tb]
comment: This term was made obsolete because the term is misleading.
synonym: "angiotensin mediated positive regulation of renal output" EXACT [GOC:dph, GOC:tb]
synonym: "angiotensin-mediated positive regulation of renal output" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of renal output by angiotensin" EXACT []
is_obsolete: true

[Term]
id: GO:0003083
name: negative regulation of renal output by angiotensin
namespace: biological_process
def: "The process in which angiotensin directly decreases the rate of natriuresis and diuresis in the kidney." [GOC:dph, GOC:mtg_cardio, GOC:tb]
synonym: "angiotensin mediated negative regulation of renal output" EXACT [GOC:dph, GOC:tb]
synonym: "angiotensin-mediated negative regulation of renal output" EXACT [GOC:dph, GOC:tb]
is_a: GO:0002019 ! regulation of renal output by angiotensin
is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure

[Term]
id: GO:0003084
name: positive regulation of systemic arterial blood pressure
namespace: biological_process
def: "The process that increases the force with which blood travels through the systemic arterial circulatory system." [GOC:mtg_cardio]
is_a: GO:0045777 ! positive regulation of blood pressure
relationship: part_of GO:0003073 ! regulation of systemic arterial blood pressure

[Term]
id: GO:0003085
name: negative regulation of systemic arterial blood pressure
namespace: biological_process
def: "The process that reduces the force with which blood travels through the systemic arterial circulatory system." [GOC:mtg_cardio]
is_a: GO:0045776 ! negative regulation of blood pressure
relationship: part_of GO:0003073 ! regulation of systemic arterial blood pressure

[Term]
id: GO:0003086
name: regulation of systemic arterial blood pressure by local renal renin-angiotensin
namespace: biological_process
def: "The process in which angiotensinogen metabolites in the kidney modulate the force with which blood passes through the renal circulatory system. The process begins when renin cleaves angiotensinogen." [GOC:mtg_cardio]
is_a: GO:0003081 ! regulation of systemic arterial blood pressure by renin-angiotensin

[Term]
id: GO:0003087
name: positive regulation of the force of heart contraction by neuronal epinephrine
namespace: biological_process
def: "The process in which the release of epinephrine from nerve endings modulates the force of heart muscle contraction." [GOC:mtg_cardio]
synonym: "increased force of heart contraction by epinephrine released from the nerve endings" EXACT []
synonym: "increased force of heart contraction by neuronal adrenaline" RELATED []
synonym: "increased force of heart contraction by neuronal epinephrine" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of heart contraction by adrenaline" RELATED []
synonym: "positive regulation of heart contraction by neuronal epinephrine" RELATED []
is_a: GO:0003059 ! positive regulation of the force of heart contraction by epinephrine
relationship: part_of GO:0003090 ! positive regulation of the force of heart contraction by neuronal epinephrine-norepinephrine

[Term]
id: GO:0003088
name: positive regulation of the force of heart contraction by circulating epinephrine
namespace: biological_process
def: "The process in which the secretion of epinephrine into the bloodstream modulates the force of heart muscle contraction." [GOC:mtg_cardio]
synonym: "increased force of heart contraction by circulating adrenaline" RELATED []
synonym: "increased force of heart contraction by epinephrine in the bloodstream" EXACT []
synonym: "positive regulation of heart contraction by circulating adrenaline" RELATED []
synonym: "positive regulation of heart contraction by circulating epinephrine" RELATED []
is_a: GO:0003059 ! positive regulation of the force of heart contraction by epinephrine
relationship: part_of GO:0003089 ! positive regulation of the force of heart contraction by circulating epinephrine-norepinephrine

[Term]
id: GO:0003089
name: positive regulation of the force of heart contraction by circulating epinephrine-norepinephrine
namespace: biological_process
def: "Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine in the bloodstream." [GOC:mtg_cardio]
synonym: "increased force of heart contraction by circulating adrenaline-noradrenaline" EXACT []
synonym: "increased force of heart contraction by circulating epinephrine-norepinephrine" EXACT [GOC:dph, GOC:tb]
synonym: "increased force of heart contraction by epinephrine-norepinephrine in the blood stream" EXACT []
synonym: "positive regulation of heart contraction by circulating adrenaline-noradrenaline" RELATED []
synonym: "positive regulation of heart contraction by circulating epinephrine-norepinephrine" RELATED []
is_a: GO:0001997 ! positive regulation of the force of heart contraction by epinephrine-norepinephrine

[Term]
id: GO:0003090
name: positive regulation of the force of heart contraction by neuronal epinephrine-norepinephrine
namespace: biological_process
def: "Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine released from the nerve endings." [GOC:mtg_cardio]
synonym: "increased force of heart contraction by epinephrine-norepinephrine released from the nerve endings" EXACT []
synonym: "increased force of heart contraction by neuronal adrenaline-noradrenaline" EXACT []
synonym: "increased force of heart contraction by neuronal epinephrine-norepinephrine" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of heart contraction by adrenaline-noradrenaline" RELATED []
synonym: "positive regulation of heart contraction by epinephrine-norepinephrine" RELATED []
is_a: GO:0001997 ! positive regulation of the force of heart contraction by epinephrine-norepinephrine

[Term]
id: GO:0003091
name: renal water homeostasis
namespace: biological_process
def: "Renal process involved in the maintenance of an internal steady state of water in the body." [GOC:mtg_cardio]
synonym: "water homeostasis by the kidney" EXACT []
is_a: GO:0003014 ! renal system process
is_a: GO:0050891 ! multicellular organismal water homeostasis

[Term]
id: GO:0003092
name: renal water retention
namespace: biological_process
def: "The process in which renal water excretion is decreased." [GOC:mtg_cardio]
synonym: "negative regulation of renal water excretion" EXACT []
is_a: GO:0035811 ! negative regulation of urine volume

[Term]
id: GO:0003093
name: regulation of glomerular filtration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glomerular filtration. Glomerular filtration is the process in which blood is filtered by the glomerulus into the renal tubule." [GOC:mtg_cardio]
is_a: GO:0001977 ! renal system process involved in regulation of blood volume
is_a: GO:0098801 ! regulation of renal system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003094 ! glomerular filtration
relationship: regulates GO:0003094 ! glomerular filtration

[Term]
id: GO:0003094
name: glomerular filtration
namespace: biological_process
def: "The process in which plasma is filtered through the glomerular membrane which consists of capillary endothelial cells, the basement membrane, and epithelial cells. The glomerular filtrate is the same as plasma except it has no significant amount of protein." [GOC:mtg_cardio, GOC:sart, ISBN:0721643949]
is_a: GO:0097205 ! renal filtration

[Term]
id: GO:0003095
name: pressure natriuresis
namespace: biological_process
def: "The process in which the volume of blood increases renal pressure and thereby results in both an increase in urine volume (diuresis) and an increase in the amount of sodium excreted in the urine (natriuresis)." [GOC:mtg_cardio]
is_a: GO:0001977 ! renal system process involved in regulation of blood volume

[Term]
id: GO:0003096
name: renal sodium ion transport
namespace: biological_process
def: "The directed movement of sodium ions (Na+) by the kidney." [GOC:mtg_cardio]
is_a: GO:0003014 ! renal system process
is_a: GO:0006814 ! sodium ion transport
is_a: GO:0044707 ! single-multicellular organism process

[Term]
id: GO:0003097
name: renal water transport
namespace: biological_process
def: "The directed movement of water (H2O) by the kidney." [GOC:mtg_cardio]
is_a: GO:0003014 ! renal system process
is_a: GO:0006833 ! water transport
is_a: GO:0044707 ! single-multicellular organism process
relationship: part_of GO:0003091 ! renal water homeostasis

[Term]
id: GO:0003098
name: tubuloglomerular feedback
namespace: biological_process
def: "The process in which blood volume is regulated due to a change in the rate of glomerular filtration. This is accomplished by a feedback mechanism that senses changes in the juxtaglomerular apparatus." [GOC:mtg_cardio]
xref: Wikipedia:Tubuloglomerular_feedback
is_a: GO:0001977 ! renal system process involved in regulation of blood volume
relationship: part_of GO:0003093 ! regulation of glomerular filtration

[Term]
id: GO:0003099
name: positive regulation of the force of heart contraction by chemical signal
namespace: biological_process
def: "Any process which increases the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine." [GOC:mtg_cardio]
synonym: "positive regulation of the force of heart muscle contraction by chemical signal" EXACT []
is_a: GO:0003057 ! regulation of the force of heart contraction by chemical signal
is_a: GO:0045823 ! positive regulation of heart contraction

[Term]
id: GO:0003100
name: regulation of systemic arterial blood pressure by endothelin
namespace: biological_process
def: "The process in which endothelin modulates the force with which blood passes through the circulatory system. Endothelin is a hormone that is released by the endothelium, and it is a vasoconstrictor." [GOC:mtg_cardio]
is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone

[Term]
id: GO:0003101
name: regulation of systemic arterial blood pressure by circulatory epinephrine-norepinephrine
namespace: biological_process
def: "The process in which epinephrine-norepinephrine modulate the force with which blood passes through the circulatory system." [GOC:mtg_cardio]
synonym: "regulation of blood pressure by circulating adrenaline-noradrenaline" RELATED []
is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone

[Term]
id: GO:0003102
name: obsolete positive regulation of diuresis by angiotensin
namespace: biological_process
def: "OBSOLETE. Any process mediated by angiotensin that increases the rate of diuresis." [GOC:dph, GOC:mtg_cardio, GOC:tb]
comment: This term was made obsolete because the term is misleading.
synonym: "angiotensin-mediated positive regulation of diuresis" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of diuresis by angiotensin" EXACT []
is_obsolete: true
consider: GO:0035810

[Term]
id: GO:0003103
name: obsolete positive regulation of diuresis
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of diuresis. Diuresis is the process of renal water excretion." [GOC:mtg_cardio]
comment: This term was made obsolete because its definition was inaccurate.
synonym: "positive regulation of diuresis" EXACT []
is_obsolete: true
consider: GO:0035810

[Term]
id: GO:0003104
name: positive regulation of glomerular filtration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glomerular filtration. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule." [GOC:mtg_cardio]
is_a: GO:0003093 ! regulation of glomerular filtration
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003094 ! glomerular filtration
relationship: positively_regulates GO:0003094 ! glomerular filtration

[Term]
id: GO:0003105
name: negative regulation of glomerular filtration
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of glomerular filtration. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule." [GOC:mtg_cardio]
is_a: GO:0003093 ! regulation of glomerular filtration
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003094 ! glomerular filtration
relationship: negatively_regulates GO:0003094 ! glomerular filtration

[Term]
id: GO:0003106
name: negative regulation of glomerular filtration by angiotensin
namespace: biological_process
def: "The process in which angiotensin directly decreases the rate of glomerular filtration in the kidney. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule." [GOC:dph, GOC:mah, GOC:tb]
synonym: "angiotensin-mediated regulation of glomerular filtration" BROAD [GOC:dph, GOC:tb]
synonym: "regulation of glomerular filtration by angiotensin" BROAD []
is_a: GO:0003083 ! negative regulation of renal output by angiotensin
relationship: part_of GO:0003105 ! negative regulation of glomerular filtration

[Term]
id: GO:0003107
name: obsolete positive regulation of natriuresis by angiotensin
namespace: biological_process
def: "OBSOLETE. The process in which angiotensin increases the rate of natriuresis indirectly via diuresis. Natriuresis is the process of renal sodium excretion." [GOC:dph, GOC:mtg_cardio, GOC:tb]
comment: This term was made obsolete because the term is misleading.
synonym: "angiotensin-mediated positive regulation of natriuresis" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of natriuresis by angiotensin" EXACT []
is_obsolete: true

[Term]
id: GO:0003108
name: negative regulation of the force of heart contraction by chemical signal
namespace: biological_process
def: "Any process which decreases the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine." [GOC:mtg_cardio]
synonym: "negative regulation of the force of heart muscle contraction by chemical signal" RELATED []
is_a: GO:0003057 ! regulation of the force of heart contraction by chemical signal
is_a: GO:0045822 ! negative regulation of heart contraction

[Term]
id: GO:0003109
name: positive regulation of the force of heart contraction by circulating norepinephrine
namespace: biological_process
def: "The process in which the secretion of norepinephrine into the bloodstream modulates the force of heart muscle contraction." [GOC:mtg_cardio]
synonym: "increased force of heart contraction by circulating noradrenaline" RELATED []
synonym: "increased force of heart contraction by circulating norepinephrine" EXACT [GOC:dph, GOC:tb]
is_a: GO:0003061 ! positive regulation of the force of heart contraction by norepinephrine

[Term]
id: GO:0003110
name: positive regulation of the force of heart contraction by neuronal norepinephrine
namespace: biological_process
def: "The process in which the release of norepinephrine from nerve endings modulates the force of heart muscle contraction." [GOC:mtg_cardio]
synonym: "increased force of heart contraction by neuronal noradrenaline" RELATED []
synonym: "increased force of heart contraction by neuronal norepinephrine" EXACT [GOC:dph, GOC:tb]
is_a: GO:0003061 ! positive regulation of the force of heart contraction by norepinephrine

[Term]
id: GO:0003111
name: positive regulation of heart rate by circulating epinephrine
namespace: biological_process
def: "The process in which the secretion of epinephrine into the bloodstream increases the rate of heart muscle contraction." [GOC:mtg_cardio]
synonym: "positive regulation of heart rate by circulating adrenaline" EXACT []
is_a: GO:0003065 ! positive regulation of heart rate by epinephrine

[Term]
id: GO:0003112
name: positive regulation of heart rate by neuronal epinephrine
namespace: biological_process
def: "The process in which the secretion of epinephrine from nerve endings increases the rate of heart muscle contraction." [GOC:mtg_cardio]
synonym: "positive regulation of heart rate by neuronal adrenaline" EXACT []
is_a: GO:0003065 ! positive regulation of heart rate by epinephrine

[Term]
id: GO:0003113
name: positive regulation of heart rate by neuronal norepinephrine
namespace: biological_process
def: "The process in which the secretion of norepinephrine released from nerve endings increases the rate of heart muscle contraction." [GOC:mtg_cardio]
synonym: "positive regulation of heart rate by neuronal noradrenaline" EXACT []
is_a: GO:0003066 ! positive regulation of heart rate by norepinephrine

[Term]
id: GO:0003114
name: positive regulation of heart rate by circulating norepinephrine
namespace: biological_process
def: "The process in which the secretion of norepinephrine into the bloodstream increases the rate of heart muscle contraction." [GOC:mtg_cardio]
synonym: "positive regulation of heart rate by circulating noradrenaline" EXACT []
is_a: GO:0003066 ! positive regulation of heart rate by norepinephrine

[Term]
id: GO:0003115
name: regulation of vasoconstriction by epinephrine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream or released by nerve endings." [GOC:mtg_cardio]
is_a: GO:0019229 ! regulation of vasoconstriction

[Term]
id: GO:0003116
name: regulation of vasoconstriction by norepinephrine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream or released by nerve endings." [GOC:mtg_cardio]
is_a: GO:0019229 ! regulation of vasoconstriction

[Term]
id: GO:0003117
name: regulation of vasoconstriction by circulating norepinephrine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream." [GOC:mtg_cardio]
synonym: "regulation of vasoconstriction by circulating noradrenaline" EXACT []
is_a: GO:0003116 ! regulation of vasoconstriction by norepinephrine

[Term]
id: GO:0003118
name: regulation of vasoconstriction by neuronal norepinephrine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of norepinephrine released by nerve endings." [GOC:mtg_cardio]
synonym: "regulation of vasoconstriction by neuronal noradrenaline" EXACT []
is_a: GO:0003116 ! regulation of vasoconstriction by norepinephrine

[Term]
id: GO:0003119
name: regulation of vasoconstriction by neuronal epinephrine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of epinephrine released by nerve endings." [GOC:mtg_cardio]
synonym: "regulation of vasoconstriction by neuronal adrenaline" EXACT []
is_a: GO:0003115 ! regulation of vasoconstriction by epinephrine

[Term]
id: GO:0003120
name: regulation of vasoconstriction by circulating epinephrine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream." [GOC:mtg_cardio]
synonym: "regulation of vasoconstriction by circulating adrenaline" EXACT []
is_a: GO:0003115 ! regulation of vasoconstriction by epinephrine

[Term]
id: GO:0003121
name: regulation of vasodilation by epinephrine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream or released by nerve endings." [GOC:mtg_cardio]
synonym: "regulation of vasodilation by adrenaline" EXACT []
is_a: GO:0042312 ! regulation of vasodilation

[Term]
id: GO:0003122
name: regulation of vasodilation by norepinephrine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream or released by nerve endings." [GOC:mtg_cardio]
synonym: "regulation of vasodilation by noradrenaline" EXACT []
is_a: GO:0042312 ! regulation of vasodilation

[Term]
id: GO:0003123
name: regulation of vasodilation by circulating epinephrine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream." [GOC:mtg_cardio]
synonym: "regulation of vasodilation by circulating adrenaline" EXACT []
is_a: GO:0003121 ! regulation of vasodilation by epinephrine

[Term]
id: GO:0003124
name: regulation of vasodilation by neuronal epinephrine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of epinephrine released by nerve endings." [GOC:mtg_cardio]
synonym: "regulation of vasodilation by neuronal adrenaline" EXACT []
is_a: GO:0003121 ! regulation of vasodilation by epinephrine

[Term]
id: GO:0003125
name: regulation of vasodilation by circulating norepinephrine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream." [GOC:mtg_cardio]
synonym: "regulation of vasodilation by circulating noradrenaline" EXACT []
is_a: GO:0003122 ! regulation of vasodilation by norepinephrine

[Term]
id: GO:0003126
name: regulation of vasodilation by neuronal norepinephrine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of norepinephrine released by nerve endings." [GOC:mtg_cardio]
synonym: "regulation of vasodilation by neuronal noradrenaline" EXACT []
is_a: GO:0003122 ! regulation of vasodilation by norepinephrine

[Term]
id: GO:0003127
name: detection of nodal flow
namespace: biological_process
def: "The series of events by which an endogenous stimulus is received by a cilium on a cell and converted to a molecular signal contributing to left/right asymmetry." [GOC:mtg_heart]
is_a: GO:0009726 ! detection of endogenous stimulus
relationship: part_of GO:0007368 ! determination of left/right symmetry
created_by: tanyaberardini
creation_date: 2009-09-22T02:45:48Z

[Term]
id: GO:0003128
name: heart field specification
namespace: biological_process
def: "The process that results in the delineation of a specific region of the lateral mesoderm into the area in which the heart will develop." [GOC:mtg_heart]
is_a: GO:0010092 ! specification of organ identity
relationship: part_of GO:0060914 ! heart formation
created_by: tanyaberardini
creation_date: 2009-09-22T02:56:05Z

[Term]
id: GO:0003129
name: heart induction
namespace: biological_process
def: "The close range interaction between mesoderm and endoderm or ectoderm that causes cells to change their fates and specify the development of the heart." [GOC:mtg_heart]
is_a: GO:0001759 ! organ induction
is_a: GO:2000826 ! regulation of heart morphogenesis
intersection_of: GO:0001759 ! organ induction
intersection_of: positively_regulates GO:0003128 ! heart field specification
relationship: positively_regulates GO:0003128 ! heart field specification
created_by: tanyaberardini
creation_date: 2009-09-22T02:58:41Z

[Term]
id: GO:0003130
name: BMP signaling pathway involved in heart induction
namespace: biological_process
def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to heart induction." [GOC:mtg_heart]
synonym: "BMP signalling pathway involved in heart induction" EXACT [GOC:mah]
is_a: GO:0030509 ! BMP signaling pathway
is_a: GO:0060850 ! regulation of transcription involved in cell fate commitment
is_a: GO:1905114 ! cell surface receptor signaling pathway involved in cell-cell signaling
intersection_of: GO:0030509 ! BMP signaling pathway
intersection_of: part_of GO:0003129 ! heart induction
relationship: part_of GO:0003129 ! heart induction
relationship: part_of GO:0003134 ! endodermal-mesodermal cell signaling involved in heart induction
created_by: tanyaberardini
creation_date: 2009-09-22T03:02:00Z

[Term]
id: GO:0003131
name: mesodermal-endodermal cell signaling
namespace: biological_process
def: "Any process that mediates the transfer of information from mesodermal cells to endodermal cells." [GOC:mtg_heart]
synonym: "mesodermal-endodermal cell signalling" EXACT [GOC:mah]
is_a: GO:0007267 ! cell-cell signaling
created_by: tanyaberardini
creation_date: 2009-09-22T03:07:34Z

[Term]
id: GO:0003132
name: mesodermal-endodermal cell signaling involved in heart induction
namespace: biological_process
def: "Any process that mediates the transfer of information from mesodermal cells to endodermal cells that contributes to heart induction." [GOC:mtg_heart]
synonym: "mesodermal-endodermal cell signalling involved in heart induction" EXACT [GOC:mah]
is_a: GO:0003131 ! mesodermal-endodermal cell signaling
is_a: GO:0045168 ! cell-cell signaling involved in cell fate commitment
intersection_of: GO:0003131 ! mesodermal-endodermal cell signaling
intersection_of: part_of GO:0003129 ! heart induction
relationship: part_of GO:0003129 ! heart induction
created_by: tanyaberardini
creation_date: 2009-09-22T03:08:52Z

[Term]
id: GO:0003133
name: endodermal-mesodermal cell signaling
namespace: biological_process
def: "Any process that mediates the transfer of information from endodermal cells to mesodermal cells." [GOC:mtg_heart]
synonym: "endodermal-mesodermal cell signalling" EXACT [GOC:mah]
is_a: GO:0007267 ! cell-cell signaling
created_by: tanyaberardini
creation_date: 2009-09-22T03:10:29Z

[Term]
id: GO:0003134
name: endodermal-mesodermal cell signaling involved in heart induction
namespace: biological_process
def: "Any process that mediates the transfer of information from endodermal cells to mesodermal cells that contributes to heart induction." [GOC:mtg_heart]
synonym: "endodermal-mesodermal cell signalling involved in heart induction" EXACT [GOC:mah]
is_a: GO:0003133 ! endodermal-mesodermal cell signaling
is_a: GO:0045168 ! cell-cell signaling involved in cell fate commitment
intersection_of: GO:0003133 ! endodermal-mesodermal cell signaling
intersection_of: part_of GO:0003129 ! heart induction
relationship: part_of GO:0003129 ! heart induction
created_by: tanyaberardini
creation_date: 2009-09-22T03:11:17Z

[Term]
id: GO:0003135
name: fibroblast growth factor receptor signaling pathway involved in heart induction
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to heart induction." [GOC:mtg_heart]
synonym: "fibroblast growth factor receptor signalling pathway involved in heart induction" EXACT [GOC:mah]
is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway
intersection_of: GO:0008543 ! fibroblast growth factor receptor signaling pathway
intersection_of: part_of GO:0003129 ! heart induction
relationship: part_of GO:0003129 ! heart induction
created_by: tanyaberardini
creation_date: 2009-09-22T03:17:49Z

[Term]
id: GO:0003136
name: negative regulation of heart induction by canonical Wnt signaling pathway
namespace: biological_process
def: "Any canonical Wnt signaling that decreases the rate, frequency or extent of heart induction." [GOC:mtg_heart, PMID:19862329]
synonym: "negative regulation of cardioblast cell fate specification by Wnt receptor signaling pathway" EXACT [GOC:dph]
synonym: "negative regulation of heart induction by canonical Wnt receptor signaling pathway" EXACT []
synonym: "negative regulation of heart induction by canonical Wnt receptor signalling pathway" EXACT [GOC:mah]
synonym: "negative regulation of heart induction by canonical Wnt-activated signaling pathway" EXACT [GOC:signaling]
is_a: GO:0009997 ! negative regulation of cardioblast cell fate specification
is_a: GO:0061316 ! canonical Wnt signaling pathway involved in heart development
is_a: GO:0100012 ! regulation of heart induction by canonical Wnt signaling pathway
is_a: GO:1901320 ! negative regulation of heart induction
relationship: negatively_regulates GO:0003129 ! heart induction
created_by: tanyaberardini
creation_date: 2009-09-22T03:26:17Z

[Term]
id: GO:0003137
name: Notch signaling pathway involved in heart induction
namespace: biological_process
def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to heart induction." [GOC:mtg_heart]
synonym: "Notch signalling pathway involved in heart induction" EXACT [GOC:mah]
is_a: GO:0007219 ! Notch signaling pathway
intersection_of: GO:0007219 ! Notch signaling pathway
intersection_of: part_of GO:0003129 ! heart induction
relationship: part_of GO:0003129 ! heart induction
created_by: tanyaberardini
creation_date: 2009-09-22T03:28:42Z

[Term]
id: GO:0003138
name: primary heart field specification
namespace: biological_process
def: "The process that results in the delineation of a specific region of the lateral mesoderm into the area which will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle." [GOC:mtg_heart, GOC:rl]
synonym: "FHS specification" EXACT [GOC:rl]
synonym: "first heart field specification" EXACT [GOC:rl]
is_a: GO:0003128 ! heart field specification
created_by: tanyaberardini
creation_date: 2009-09-22T03:47:24Z

[Term]
id: GO:0003139
name: secondary heart field specification
namespace: biological_process
def: "The process that results in the delineation of a specific region of the lateral mesoderm into the area which will form the majority of the mesodermal component of the right ventricle, arterial pole (outflow tract) and venous pole (inflow tract)." [GOC:mtg_heart, GOC:rl, PMID:17276708]
synonym: "anterior heart field specification" NARROW [GOC:mtg_heart]
synonym: "second heart field specification" EXACT [GOC:mtg_heart, PMID:17276708]
synonym: "SHF specification" EXACT [GOC:rl, PMID:22449840]
is_a: GO:0003128 ! heart field specification
created_by: tanyaberardini
creation_date: 2009-09-22T03:47:56Z

[Term]
id: GO:0003140
name: determination of left/right asymmetry in lateral mesoderm
namespace: biological_process
def: "The establishment of the lateral mesoderm with respect to the left and right halves." [GOC:mtg_heart]
is_a: GO:0007368 ! determination of left/right symmetry
relationship: part_of GO:0048368 ! lateral mesoderm development
created_by: tanyaberardini
creation_date: 2009-09-22T03:58:29Z

[Term]
id: GO:0003141
name: obsolete transforming growth factor beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry
namespace: biological_process
def: "OBSOLETE. The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands that contributes to lateral mesoderm left/right asymmetry determination." [GOC:mtg_heart]
comment: This term was made obsolete because it describes involvement of the nodal signaling pathway in lateral mesoderm left/right asymmetry. Nodal proteins are members of the TGF-beta superfamily, but are distinct from TGF-beta proteins themselves. TGF-beta proteins are not currently known to regulate left/right asymmetry in the lateral mesoderm.
synonym: "TGF-beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT []
synonym: "TGF-beta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT []
synonym: "TGFbeta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT []
synonym: "TGFbeta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT []
synonym: "transforming growth factor beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT []
synonym: "transforming growth factor beta receptor signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT []
synonym: "transforming growth factor beta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT []
is_obsolete: true
replaced_by: GO:1900164
created_by: tanyaberardini
creation_date: 2009-09-22T04:03:22Z

[Term]
id: GO:0003142
name: cardiogenic plate morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the cardiogenic plate are generated and organized. The cardiogenic plate is the first recognizable structure derived from the heart field." [GOC:mtg_heart]
synonym: "cardiac crescent morphogenesis" EXACT [GOC:mtg_heart]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0003007 ! heart morphogenesis
created_by: tanyaberardini
creation_date: 2009-09-22T04:12:18Z

[Term]
id: GO:0003143
name: embryonic heart tube morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart." [GOC:mtg_heart]
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0060562 ! epithelial tube morphogenesis
relationship: part_of GO:0003007 ! heart morphogenesis
relationship: part_of GO:0035050 ! embryonic heart tube development
relationship: part_of GO:0048562 ! embryonic organ morphogenesis
created_by: tanyaberardini
creation_date: 2009-09-22T04:21:17Z

[Term]
id: GO:0003144
name: embryonic heart tube formation
namespace: biological_process
def: "The process that gives rise to the embryonic heart tube. This process pertains to the initial formation of a structure from unspecified parts. The embryonic heart tube is an epithelial tube that will give rise to the mature heart." [GOC:mtg_heart]
is_a: GO:0001838 ! embryonic epithelial tube formation
relationship: part_of GO:0003143 ! embryonic heart tube morphogenesis
created_by: tanyaberardini
creation_date: 2009-09-22T04:22:34Z

[Term]
id: GO:0003145
name: embryonic heart tube formation via epithelial folding
namespace: biological_process
def: "The process that gives rise to the embryonic heart tube by the cells of the heart field along a linear axis." [GOC:mtg_heart]
is_a: GO:0003144 ! embryonic heart tube formation
created_by: tanyaberardini
creation_date: 2009-09-22T04:26:03Z

[Term]
id: GO:0003146
name: heart jogging
namespace: biological_process
def: "The morphogenetic process in which the heart cone is displaced to the left with respect to the vector of the anterior-posterior axis." [GOC:mtg_heart, PMID:9334285]
synonym: "cardiac jogging" EXACT [GOC:mtg_heart]
is_a: GO:0003143 ! embryonic heart tube morphogenesis
relationship: part_of GO:0061371 ! determination of heart left/right asymmetry
created_by: tanyaberardini
creation_date: 2009-09-22T06:11:41Z

[Term]
id: GO:0003147
name: neural crest cell migration involved in heart formation
namespace: biological_process
def: "The characteristic movement of a cell from the dorsal ridge of the neural tube towards the heart and that contributes to heart formation." [GOC:mtg_heart]
is_a: GO:0001755 ! neural crest cell migration
is_a: GO:0060974 ! cell migration involved in heart formation
intersection_of: GO:0001755 ! neural crest cell migration
intersection_of: part_of GO:0060914 ! heart formation
relationship: part_of GO:0060914 ! heart formation
relationship: part_of GO:0061308 ! cardiac neural crest cell development involved in heart development
created_by: tanyaberardini
creation_date: 2009-09-22T04:29:55Z

[Term]
id: GO:0003148
name: outflow tract septum morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract." [GOC:mtg_heart]
is_a: GO:0060411 ! cardiac septum morphogenesis
relationship: part_of GO:0003151 ! outflow tract morphogenesis
created_by: tanyaberardini
creation_date: 2009-09-22T07:51:01Z

[Term]
id: GO:0003149
name: membranous septum morphogenesis
namespace: biological_process
def: "The process in which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum." [GOC:mtg_heart]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0060412 ! ventricular septum morphogenesis
created_by: tanyaberardini
creation_date: 2009-09-22T07:51:41Z

[Term]
id: GO:0003150
name: muscular septum morphogenesis
namespace: biological_process
def: "The process in which the muscular septum is generated and organized. The muscular septum is the lower part of the ventricular septum." [GOC:mtg_heart]
is_a: GO:0060415 ! muscle tissue morphogenesis
relationship: part_of GO:0060412 ! ventricular septum morphogenesis
created_by: tanyaberardini
creation_date: 2009-09-22T07:53:28Z

[Term]
id: GO:0003151
name: outflow tract morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries." [GOC:mtg_heart, UBERON:0004145]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0003007 ! heart morphogenesis
created_by: tanyaberardini
creation_date: 2009-09-22T07:59:24Z

[Term]
id: GO:0003152
name: morphogenesis of an epithelial fold involved in embryonic heart tube formation
namespace: biological_process
def: "The morphogenetic process in which an epithelial sheet bends along a linear axis, contributing to embryonic heart tube formation." [GOC:mtg_heart]
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0060571 ! morphogenesis of an epithelial fold
intersection_of: GO:0060571 ! morphogenesis of an epithelial fold
intersection_of: part_of GO:0003144 ! embryonic heart tube formation
relationship: part_of GO:0003144 ! embryonic heart tube formation
relationship: part_of GO:0003145 ! embryonic heart tube formation via epithelial folding
created_by: tanyaberardini
creation_date: 2009-09-23T10:10:24Z

[Term]
id: GO:0003153
name: closure of embryonic heart tube
namespace: biological_process
def: "Creation of the central hole of the embryonic heart tube by sealing the edges of an epithelial fold." [GOC:mtg_heart]
is_a: GO:0060606 ! tube closure
relationship: part_of GO:0003145 ! embryonic heart tube formation via epithelial folding
created_by: tanyaberardini
creation_date: 2009-09-23T10:14:54Z

[Term]
id: GO:0003154
name: BMP signaling pathway involved in determination of left/right symmetry
namespace: biological_process
def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the determination of left/right symmetry." [GOC:mtg_heart, GOC:signaling]
synonym: "BMP signaling pathway involved in determination of left/right asymmetry" EXACT [GOC:dph]
synonym: "BMP signalling pathway involved in determination of left/right symmetry" EXACT [GOC:mah]
is_a: GO:0030509 ! BMP signaling pathway
is_a: GO:1900094 ! regulation of transcription from RNA polymerase II promoter involved in determination of left/right symmetry
intersection_of: GO:0030509 ! BMP signaling pathway
intersection_of: part_of GO:0007368 ! determination of left/right symmetry
relationship: part_of GO:0007368 ! determination of left/right symmetry
created_by: tanyaberardini
creation_date: 2009-09-24T05:34:57Z

[Term]
id: GO:0003155
name: BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry
namespace: biological_process
def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to the determination of lateral mesoderm left/right asymmetry." [GOC:mtg_heart]
synonym: "BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT []
synonym: "BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:mah]
is_a: GO:0003154 ! BMP signaling pathway involved in determination of left/right symmetry
intersection_of: GO:0030509 ! BMP signaling pathway
intersection_of: part_of GO:0003140 ! determination of left/right asymmetry in lateral mesoderm
relationship: part_of GO:0003140 ! determination of left/right asymmetry in lateral mesoderm
created_by: tanyaberardini
creation_date: 2009-09-24T05:42:17Z

[Term]
id: GO:0003156
name: regulation of organ formation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of organ formation. Organ formation is the process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment." [GOC:dph, GOC:mtg_heart, GOC:tb]
is_a: GO:2000027 ! regulation of organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048645 ! organ formation
relationship: regulates GO:0048645 ! organ formation
created_by: tanyaberardini
creation_date: 2009-09-30T11:21:09Z

[Term]
id: GO:0003157
name: endocardium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:mtg_heart]
is_a: GO:0003158 ! endothelium development
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0007507 ! heart development
created_by: dph
creation_date: 2009-10-01T12:42:27Z

[Term]
id: GO:0003158
name: endothelium development
namespace: biological_process
def: "The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells." [GOC:mtg_heart]
is_a: GO:0060429 ! epithelium development
created_by: dph
creation_date: 2009-10-01T12:50:57Z

[Term]
id: GO:0003159
name: morphogenesis of an endothelium
namespace: biological_process
def: "The process in which the anatomical structure of an endothelium is generated and organized. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells." [GOC:mtg_heart]
is_a: GO:0002009 ! morphogenesis of an epithelium
relationship: part_of GO:0003158 ! endothelium development
created_by: dph
creation_date: 2009-10-01T01:34:06Z

[Term]
id: GO:0003160
name: endocardium morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the endocardium is generated and organized. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:mtg_heart]
is_a: GO:0003159 ! morphogenesis of an endothelium
relationship: part_of GO:0003157 ! endocardium development
created_by: dph
creation_date: 2009-10-01T01:37:26Z

[Term]
id: GO:0003161
name: cardiac conduction system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat." [GOC:mtg_heart]
synonym: "cardiac impulse conducting system development" EXACT [GOC:mtg_heart]
synonym: "heart conduction system development" EXACT [GOC:mtg_heart]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048738 ! cardiac muscle tissue development
relationship: part_of GO:0007507 ! heart development
created_by: dph
creation_date: 2009-10-01T01:57:16Z

[Term]
id: GO:0003162
name: atrioventricular node development
namespace: biological_process
def: "The process whose specific outcome is the progression of the atrioventricular (AV) node over time, from its formation to the mature structure. The AV node is part of the cardiac conduction system that controls the timing of ventricle contraction by receiving electrical signals from the sinoatrial (SA) node and relaying them to the His-Purkinje system." [GOC:mtg_heart]
synonym: "AV node development" EXACT [GOC:mtg_heart]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048738 ! cardiac muscle tissue development
relationship: part_of GO:0003161 ! cardiac conduction system development
created_by: dph
creation_date: 2009-10-01T02:05:13Z

[Term]
id: GO:0003163
name: sinoatrial node development
namespace: biological_process
def: "The process whose specific outcome is the progression of the sinoatrial (SA) node over time, from its formation to the mature structure. The SA node is part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node." [GOC:mtg_heart]
synonym: "SA node development" EXACT [GOC:mtg_heart]
synonym: "SAN development" EXACT [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "sinus node development" NARROW [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0048738 ! cardiac muscle tissue development
relationship: part_of GO:0003161 ! cardiac conduction system development
created_by: dph
creation_date: 2009-10-01T02:06:09Z

[Term]
id: GO:0003164
name: His-Purkinje system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the His-Purkinje system over time, from its formation to the mature structure. The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles." [GOC:mtg_heart]
is_a: GO:0003229 ! ventricular cardiac muscle tissue development
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0003161 ! cardiac conduction system development
created_by: dph
creation_date: 2009-10-01T02:07:12Z

[Term]
id: GO:0003165
name: Purkinje myocyte development
namespace: biological_process
def: "The process whose specific outcome is the progression of a Purkinje myocyte over time, from its formation to the mature structure. The Purkinje myocyte (also known as cardiac Purkinje fiber) is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart]
synonym: "cardiac Purkinje fiber development" EXACT []
is_a: GO:0003229 ! ventricular cardiac muscle tissue development
relationship: part_of GO:0003164 ! His-Purkinje system development
created_by: dph
creation_date: 2009-10-01T02:07:50Z

[Term]
id: GO:0003166
name: bundle of His development
namespace: biological_process
def: "The process whose specific outcome is the progression of the bundle of His over time, from its formation to the mature structure. The bundle of His is part of the His-Purkinje system that transmits signals from the AV node to the cardiac Purkinje fibers." [GOC:mtg_heart]
synonym: "atrioventricular bundle development" EXACT [GOC:mtg_heart]
is_a: GO:0003229 ! ventricular cardiac muscle tissue development
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0003164 ! His-Purkinje system development
created_by: dph
creation_date: 2009-10-01T02:08:43Z

[Term]
id: GO:0003167
name: atrioventricular bundle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell of the atrioventricular bundle. These cells are specialized cardiomyocytes that transmit signals from the AV node to the cardiac Purkinje fibers." [GOC:mtg_heart]
synonym: "AV bundle cell differentiation" EXACT [GOC:mtg_heart]
is_a: GO:0060932 ! His-Purkinje system cell differentiation
relationship: part_of GO:0003166 ! bundle of His development
created_by: dph
creation_date: 2009-10-01T02:48:23Z

[Term]
id: GO:0003168
name: Purkinje myocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a Purkinje myocyte (also known as cardiac Purkinje fiber cell). These cells are specialized cardiomyocytes that receive signals from the bundle of His and innervate the ventricular cardiac muscle." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart]
synonym: "cardiac Purkinje fiber cell differentiation" EXACT []
is_a: GO:0060932 ! His-Purkinje system cell differentiation
relationship: part_of GO:0003165 ! Purkinje myocyte development
created_by: dph
creation_date: 2009-10-01T02:49:54Z

[Term]
id: GO:0003169
name: coronary vein morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of veins of the heart are generated and organized." [GOC:mtg_heart]
is_a: GO:0048845 ! venous blood vessel morphogenesis
is_a: GO:0060977 ! coronary vasculature morphogenesis
created_by: dph
creation_date: 2009-10-08T10:45:41Z

[Term]
id: GO:0003170
name: heart valve development
namespace: biological_process
def: "The progression of a heart valve over time, from its formation to the mature structure. A heart valve is a structure that restricts the flow of blood to different regions of the heart and forms from an endocardial cushion." [GOC:mtg_heart]
synonym: "cardiac valve development" EXACT [GOC:mtg_heart]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007507 ! heart development
created_by: dph
creation_date: 2009-10-08T10:50:09Z

[Term]
id: GO:0003171
name: atrioventricular valve development
namespace: biological_process
def: "The progression of the atrioventricular valve over time, from its formation to the mature structure." [GOC:mtg_heart]
synonym: "AV valve development" EXACT [GOC:mah]
is_a: GO:0003170 ! heart valve development
created_by: dph
creation_date: 2009-10-08T11:14:21Z

[Term]
id: GO:0003172
name: sinoatrial valve development
namespace: biological_process
def: "The progression of the sinoatrial valve over time, from its formation to the mature structure." [GOC:mtg_heart]
synonym: "SA valve development" EXACT [GOC:mah]
is_a: GO:0003170 ! heart valve development
created_by: dph
creation_date: 2009-10-08T11:15:39Z

[Term]
id: GO:0003173
name: ventriculo bulbo valve development
namespace: biological_process
def: "The progression of the ventriculo bulbo valve over time, from its formation to the mature structure." [GOC:mtg_heart]
is_a: GO:0003170 ! heart valve development
created_by: dph
creation_date: 2009-10-08T11:16:25Z

[Term]
id: GO:0003174
name: mitral valve development
namespace: biological_process
def: "The progression of the mitral valve over time, from its formation to the mature structure." [GOC:mtg_heart]
is_a: GO:0003171 ! atrioventricular valve development
created_by: dph
creation_date: 2009-10-08T11:17:22Z

[Term]
id: GO:0003175
name: tricuspid valve development
namespace: biological_process
def: "The progression of the tricuspid valve over time, from its formation to the mature structure." [GOC:mtg_heart]
is_a: GO:0003171 ! atrioventricular valve development
created_by: dph
creation_date: 2009-10-08T11:18:12Z

[Term]
id: GO:0003176
name: aortic valve development
namespace: biological_process
def: "The progression of the aortic valve over time, from its formation to the mature structure." [GOC:mtg_heart]
is_a: GO:0003170 ! heart valve development
created_by: dph
creation_date: 2009-10-08T11:18:55Z

[Term]
id: GO:0003177
name: pulmonary valve development
namespace: biological_process
def: "The progression of the pulmonary valve over time, from its formation to the mature structure." [GOC:mtg_heart]
is_a: GO:0003170 ! heart valve development
created_by: dph
creation_date: 2009-10-08T11:19:44Z

[Term]
id: GO:0003178
name: coronary sinus valve development
namespace: biological_process
def: "The progression of the valve of the coronary sinus over time, from its formation to the mature structure." [GOC:mtg_heart]
is_a: GO:0003170 ! heart valve development
created_by: dph
creation_date: 2009-10-08T11:21:43Z

[Term]
id: GO:0003179
name: heart valve morphogenesis
namespace: biological_process
def: "The process in which the structure of a heart valve is generated and organized." [GOC:mtg_heart]
synonym: "heart valve remodeling" NARROW [GOC:vk, GOC:yaf]
synonym: "heart valve remodelling" NARROW [GOC:vk, GOC:yaf]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0003170 ! heart valve development
created_by: dph
creation_date: 2009-10-08T11:23:48Z

[Term]
id: GO:0003180
name: aortic valve morphogenesis
namespace: biological_process
def: "The process in which the structure of the aortic valve is generated and organized." [GOC:mtg_heart]
is_a: GO:0003179 ! heart valve morphogenesis
relationship: part_of GO:0003176 ! aortic valve development
created_by: dph
creation_date: 2009-10-08T11:29:42Z

[Term]
id: GO:0003181
name: atrioventricular valve morphogenesis
namespace: biological_process
def: "The process in which the structure of the atrioventricular valve is generated and organized." [GOC:mtg_heart]
synonym: "AV valve morphogenesis" EXACT [GOC:mah]
is_a: GO:0003179 ! heart valve morphogenesis
relationship: part_of GO:0003171 ! atrioventricular valve development
created_by: dph
creation_date: 2009-10-08T11:31:59Z

[Term]
id: GO:0003182
name: coronary sinus valve morphogenesis
namespace: biological_process
def: "The process in which the structure of the coronary sinus valve is generated and organized." [GOC:mtg_heart]
is_a: GO:0003179 ! heart valve morphogenesis
relationship: part_of GO:0003178 ! coronary sinus valve development
created_by: dph
creation_date: 2009-10-08T11:33:31Z

[Term]
id: GO:0003183
name: mitral valve morphogenesis
namespace: biological_process
def: "The process in which the structure of the mitral valve is generated and organized." [GOC:mtg_heart]
is_a: GO:0003181 ! atrioventricular valve morphogenesis
relationship: part_of GO:0003174 ! mitral valve development
created_by: dph
creation_date: 2009-10-08T12:02:01Z

[Term]
id: GO:0003184
name: pulmonary valve morphogenesis
namespace: biological_process
def: "The process in which the structure of the pulmonary valve is generated and organized." [GOC:mtg_heart]
is_a: GO:0003179 ! heart valve morphogenesis
relationship: part_of GO:0003177 ! pulmonary valve development
created_by: dph
creation_date: 2009-10-08T12:03:35Z

[Term]
id: GO:0003185
name: sinoatrial valve morphogenesis
namespace: biological_process
def: "The process in which the structure of the sinoatrial valve is generated and organized." [GOC:mtg_heart]
synonym: "SA valve morphogenesis" EXACT [GOC:mah]
is_a: GO:0003179 ! heart valve morphogenesis
relationship: part_of GO:0003172 ! sinoatrial valve development
created_by: dph
creation_date: 2009-10-08T12:04:52Z

[Term]
id: GO:0003186
name: tricuspid valve morphogenesis
namespace: biological_process
def: "The process in which the structure of the tricuspid valve is generated and organized." [GOC:mtg_heart]
is_a: GO:0003181 ! atrioventricular valve morphogenesis
relationship: part_of GO:0003175 ! tricuspid valve development
created_by: dph
creation_date: 2009-10-08T12:05:45Z

[Term]
id: GO:0003187
name: ventriculo bulbo valve morphogenesis
namespace: biological_process
def: "The process in which the structure of the ventriculo bulbo valve is generated and organized." [GOC:mtg_heart]
is_a: GO:0003179 ! heart valve morphogenesis
relationship: part_of GO:0003173 ! ventriculo bulbo valve development
created_by: dph
creation_date: 2009-10-08T12:07:00Z

[Term]
id: GO:0003188
name: heart valve formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a heart valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0003179 ! heart valve morphogenesis
created_by: dph
creation_date: 2009-10-08T12:20:15Z

[Term]
id: GO:0003189
name: aortic valve formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the aortic valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]
is_a: GO:0003188 ! heart valve formation
relationship: part_of GO:0003180 ! aortic valve morphogenesis
created_by: dph
creation_date: 2009-10-08T01:05:44Z

[Term]
id: GO:0003190
name: atrioventricular valve formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the atrioventricular valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]
synonym: "AV valve formation" EXACT [GOC:mah]
is_a: GO:0003188 ! heart valve formation
relationship: part_of GO:0003181 ! atrioventricular valve morphogenesis
created_by: dph
creation_date: 2009-10-08T01:07:28Z

[Term]
id: GO:0003191
name: coronary sinus valve formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the coronary sinus valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]
is_a: GO:0003188 ! heart valve formation
relationship: part_of GO:0003182 ! coronary sinus valve morphogenesis
created_by: dph
creation_date: 2009-10-08T01:09:04Z

[Term]
id: GO:0003192
name: mitral valve formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the mitral valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]
is_a: GO:0003190 ! atrioventricular valve formation
relationship: part_of GO:0003183 ! mitral valve morphogenesis
created_by: dph
creation_date: 2009-10-08T01:10:19Z

[Term]
id: GO:0003193
name: pulmonary valve formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the pulmonary valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]
is_a: GO:0003188 ! heart valve formation
relationship: part_of GO:0003184 ! pulmonary valve morphogenesis
created_by: dph
creation_date: 2009-10-08T01:11:20Z

[Term]
id: GO:0003194
name: sinoatrial valve formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the sinoatrial valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]
synonym: "SA valve formation" EXACT [GOC:mah]
is_a: GO:0003188 ! heart valve formation
relationship: part_of GO:0003185 ! sinoatrial valve morphogenesis
created_by: dph
creation_date: 2009-10-08T01:12:45Z

[Term]
id: GO:0003195
name: tricuspid valve formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the tricuspid valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]
is_a: GO:0003190 ! atrioventricular valve formation
relationship: part_of GO:0003186 ! tricuspid valve morphogenesis
created_by: dph
creation_date: 2009-10-08T01:14:40Z

[Term]
id: GO:0003196
name: ventriculo bulbo valve formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the ventriculo bulbo valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]
is_a: GO:0003188 ! heart valve formation
relationship: part_of GO:0003187 ! ventriculo bulbo valve morphogenesis
created_by: dph
creation_date: 2009-10-08T01:16:02Z

[Term]
id: GO:0003197
name: endocardial cushion development
namespace: biological_process
def: "The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart]
is_a: GO:0060485 ! mesenchyme development
relationship: part_of GO:0007507 ! heart development
created_by: dph
creation_date: 2009-10-08T01:17:43Z

[Term]
id: GO:0003198
name: epithelial to mesenchymal transition involved in endocardial cushion formation
namespace: biological_process
def: "A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of the endocardial cushion." [GOC:mtg_heart]
is_a: GO:0060317 ! cardiac epithelial to mesenchymal transition
intersection_of: GO:0060317 ! cardiac epithelial to mesenchymal transition
intersection_of: part_of GO:0003272 ! endocardial cushion formation
relationship: part_of GO:0003272 ! endocardial cushion formation
created_by: dph
creation_date: 2009-10-08T01:27:42Z

[Term]
id: GO:0003199
name: endocardial cushion to mesenchymal transition involved in heart valve formation
namespace: biological_process
def: "A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of a cardiac valve." [GOC:mtg_heart]
synonym: "endocardial cushion to mesenchymal transition involved in valve formation" EXACT [GOC:bf]
is_a: GO:0090500 ! endocardial cushion to mesenchymal transition
intersection_of: GO:0090500 ! endocardial cushion to mesenchymal transition
intersection_of: part_of GO:0003188 ! heart valve formation
relationship: part_of GO:0003188 ! heart valve formation
created_by: dph
creation_date: 2009-10-08T01:31:21Z

[Term]
id: GO:0003200
name: endocardial cushion to mesenchymal transition involved in heart chamber septation
namespace: biological_process
def: "A transition where an endocardial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of the heart septum." [GOC:mtg_heart]
is_a: GO:0090500 ! endocardial cushion to mesenchymal transition
intersection_of: GO:0090500 ! endocardial cushion to mesenchymal transition
intersection_of: part_of GO:0060411 ! cardiac septum morphogenesis
relationship: part_of GO:0060411 ! cardiac septum morphogenesis
created_by: dph
creation_date: 2009-10-08T01:34:31Z

[Term]
id: GO:0003201
name: epithelial to mesenchymal transition involved in coronary vasculature morphogenesis
namespace: biological_process
def: "A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the shaping of the coronary vasculature." [GOC:mtg_heart]
is_a: GO:0060317 ! cardiac epithelial to mesenchymal transition
intersection_of: GO:0060317 ! cardiac epithelial to mesenchymal transition
intersection_of: part_of GO:0060977 ! coronary vasculature morphogenesis
relationship: part_of GO:0060977 ! coronary vasculature morphogenesis
created_by: dph
creation_date: 2009-10-08T01:36:54Z

[Term]
id: GO:0003202
name: endocardial cushion to mesenchymal transition involved in cardiac skeleton development
namespace: biological_process
def: "A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will give rise to the cardiac skeleton." [GOC:mtg_heart]
is_a: GO:0090500 ! endocardial cushion to mesenchymal transition
intersection_of: GO:0090500 ! endocardial cushion to mesenchymal transition
intersection_of: part_of GO:0003204 ! cardiac skeleton development
relationship: part_of GO:0003204 ! cardiac skeleton development
created_by: dph
creation_date: 2009-10-08T01:39:57Z

[Term]
id: GO:0003203
name: endocardial cushion morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart]
is_a: GO:0072132 ! mesenchyme morphogenesis
relationship: part_of GO:0003007 ! heart morphogenesis
relationship: part_of GO:0003197 ! endocardial cushion development
created_by: dph
creation_date: 2009-10-08T01:43:22Z

[Term]
id: GO:0003204
name: cardiac skeleton development
namespace: biological_process
def: "The progression of the cardiac skeleton over time, from its formation to the mature structure. The cardiac skeleton is a specialized extracellular matrix that separates the atria from the ventricles and provides physical support for the heart." [GOC:mtg_heart]
synonym: "heart fibrous skeleton development" EXACT [GOC:mtg_heart]
is_a: GO:0061448 ! connective tissue development
relationship: part_of GO:0007507 ! heart development
created_by: dph
creation_date: 2009-10-13T09:05:04Z

[Term]
id: GO:0003205
name: cardiac chamber development
namespace: biological_process
def: "The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007507 ! heart development
created_by: dph
creation_date: 2009-10-13T09:11:18Z

[Term]
id: GO:0003206
name: cardiac chamber morphogenesis
namespace: biological_process
def: "The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart]
synonym: "heart chamber morphogenesis" EXACT [GOC:mtg_heart]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0003007 ! heart morphogenesis
relationship: part_of GO:0003205 ! cardiac chamber development
created_by: dph
creation_date: 2009-10-13T09:14:51Z

[Term]
id: GO:0003207
name: cardiac chamber formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart]
synonym: "heart chamber formation" EXACT [GOC:mtg_heart]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0003206 ! cardiac chamber morphogenesis
created_by: dph
creation_date: 2009-10-13T09:29:13Z

[Term]
id: GO:0003208
name: cardiac ventricle morphogenesis
namespace: biological_process
def: "The process in which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart]
is_a: GO:0003206 ! cardiac chamber morphogenesis
relationship: part_of GO:0003231 ! cardiac ventricle development
created_by: dph
creation_date: 2009-10-13T09:38:44Z

[Term]
id: GO:0003209
name: cardiac atrium morphogenesis
namespace: biological_process
def: "The process in which the cardiac atrium is generated and organized. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart]
is_a: GO:0003206 ! cardiac chamber morphogenesis
relationship: part_of GO:0003230 ! cardiac atrium development
created_by: dph
creation_date: 2009-10-13T09:39:44Z

[Term]
id: GO:0003210
name: cardiac atrium formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a cardiac atrium from unspecified parts. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart]
is_a: GO:0003207 ! cardiac chamber formation
relationship: part_of GO:0003209 ! cardiac atrium morphogenesis
created_by: dph
creation_date: 2009-10-13T09:44:25Z

[Term]
id: GO:0003211
name: cardiac ventricle formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a cardiac ventricle from unspecified parts. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart]
is_a: GO:0003207 ! cardiac chamber formation
relationship: part_of GO:0003208 ! cardiac ventricle morphogenesis
created_by: dph
creation_date: 2009-10-13T09:46:27Z

[Term]
id: GO:0003212
name: cardiac left atrium morphogenesis
namespace: biological_process
def: "The process in which the left cardiac atrium is generated and organized." [GOC:mtg_heart]
is_a: GO:0003209 ! cardiac atrium morphogenesis
created_by: dph
creation_date: 2009-10-13T09:48:16Z

[Term]
id: GO:0003213
name: cardiac right atrium morphogenesis
namespace: biological_process
def: "The process in which the right cardiac atrium is generated and organized." [GOC:mtg_heart]
is_a: GO:0003209 ! cardiac atrium morphogenesis
created_by: dph
creation_date: 2009-10-13T09:49:03Z

[Term]
id: GO:0003214
name: cardiac left ventricle morphogenesis
namespace: biological_process
def: "The process in which the left cardiac ventricle is generated and organized." [GOC:mtg_heart]
is_a: GO:0003208 ! cardiac ventricle morphogenesis
created_by: dph
creation_date: 2009-10-13T09:50:08Z

[Term]
id: GO:0003215
name: cardiac right ventricle morphogenesis
namespace: biological_process
def: "The process in which the right cardiac ventricle is generated and organized." [GOC:mtg_heart]
is_a: GO:0003208 ! cardiac ventricle morphogenesis
created_by: dph
creation_date: 2009-10-13T09:50:57Z

[Term]
id: GO:0003216
name: cardiac left atrium formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a left cardiac atrium from unspecified parts." [GOC:mtg_heart]
is_a: GO:0003210 ! cardiac atrium formation
relationship: part_of GO:0003212 ! cardiac left atrium morphogenesis
created_by: dph
creation_date: 2009-10-13T09:52:31Z

[Term]
id: GO:0003217
name: cardiac right atrium formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a cardiac right atrium from unspecified parts." [GOC:mtg_heart]
is_a: GO:0003210 ! cardiac atrium formation
relationship: part_of GO:0003213 ! cardiac right atrium morphogenesis
created_by: dph
creation_date: 2009-10-13T09:53:12Z

[Term]
id: GO:0003218
name: cardiac left ventricle formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a left cardiac ventricle from unspecified parts." [GOC:mtg_heart]
is_a: GO:0003211 ! cardiac ventricle formation
relationship: part_of GO:0003214 ! cardiac left ventricle morphogenesis
created_by: dph
creation_date: 2009-10-13T09:54:33Z

[Term]
id: GO:0003219
name: cardiac right ventricle formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a right cardiac ventricle from unspecified parts." [GOC:mtg_heart]
is_a: GO:0003211 ! cardiac ventricle formation
relationship: part_of GO:0003215 ! cardiac right ventricle morphogenesis
created_by: dph
creation_date: 2009-10-13T09:55:38Z

[Term]
id: GO:0003220
name: left ventricular cardiac muscle tissue morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of left cardiac ventricle muscle are generated and organized." [GOC:mtg_heart]
synonym: "left ventricular myocardium morphogenesis" EXACT [GOC:mtg_heart]
is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis
relationship: part_of GO:0003214 ! cardiac left ventricle morphogenesis
created_by: dph
creation_date: 2009-10-13T10:18:05Z

[Term]
id: GO:0003221
name: right ventricular cardiac muscle tissue morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the right cardiac ventricle muscle are generated and organized." [GOC:mtg_heart]
synonym: "right ventricle myocardium morphogenesis" EXACT [GOC:mtg_heart]
is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis
relationship: part_of GO:0003215 ! cardiac right ventricle morphogenesis
created_by: dph
creation_date: 2009-10-13T10:26:33Z

[Term]
id: GO:0003222
name: ventricular trabecula myocardium morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the trabecular cardiac ventricle muscle are generated and organized." [GOC:mtg_heart]
synonym: "trabecula carnea morphogenesis" RELATED [GOC:dph]
is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis
is_a: GO:0061384 ! heart trabecula morphogenesis
created_by: dph
creation_date: 2009-10-13T10:33:00Z

[Term]
id: GO:0003223
name: ventricular compact myocardium morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the compact cardiac ventricle muscle are generated and organized." [GOC:mtg_heart]
is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis
created_by: dph
creation_date: 2009-10-13T10:34:21Z

[Term]
id: GO:0003224
name: left ventricular compact myocardium morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of cardiac left ventricular compact myocardium are generated and organized." [GOC:mtg_heart]
is_a: GO:0003220 ! left ventricular cardiac muscle tissue morphogenesis
is_a: GO:0003223 ! ventricular compact myocardium morphogenesis
created_by: dph
creation_date: 2009-10-13T10:43:36Z

[Term]
id: GO:0003225
name: left ventricular trabecular myocardium morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of cardiac left ventricular trabecular myocardium are generated and organized." [GOC:mtg_heart]
is_a: GO:0003220 ! left ventricular cardiac muscle tissue morphogenesis
is_a: GO:0003222 ! ventricular trabecula myocardium morphogenesis
created_by: dph
creation_date: 2009-10-13T10:45:09Z

[Term]
id: GO:0003226
name: right ventricular compact myocardium morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the right ventricular compact myocardium are generated and organized." [GOC:mtg_heart]
is_a: GO:0003221 ! right ventricular cardiac muscle tissue morphogenesis
is_a: GO:0003223 ! ventricular compact myocardium morphogenesis
created_by: dph
creation_date: 2009-10-13T10:48:42Z

[Term]
id: GO:0003227
name: right ventricular trabecular myocardium morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the right ventricular myocardium are generated and organized." [GOC:mtg_heart]
is_a: GO:0003221 ! right ventricular cardiac muscle tissue morphogenesis
is_a: GO:0003222 ! ventricular trabecula myocardium morphogenesis
created_by: dph
creation_date: 2009-10-13T10:50:59Z

[Term]
id: GO:0003228
name: atrial cardiac muscle tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of cardiac muscle of the atrium over time, from its formation to the mature structure." [GOC:mtg_heart]
synonym: "atrial myocardium development" EXACT [GOC:mtg_heart]
is_a: GO:0048738 ! cardiac muscle tissue development
created_by: dph
creation_date: 2009-10-13T10:53:18Z

[Term]
id: GO:0003229
name: ventricular cardiac muscle tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure." [GOC:mtg_heart]
synonym: "ventricular myocardium development" EXACT [GOC:mtg_heart]
is_a: GO:0048738 ! cardiac muscle tissue development
created_by: dph
creation_date: 2009-10-13T10:56:01Z

[Term]
id: GO:0003230
name: cardiac atrium development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cardiac atrium over time, from its formation to the mature structure. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart]
is_a: GO:0003205 ! cardiac chamber development
created_by: dph
creation_date: 2009-10-13T11:02:07Z

[Term]
id: GO:0003231
name: cardiac ventricle development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart]
is_a: GO:0003205 ! cardiac chamber development
created_by: dph
creation_date: 2009-10-13T11:03:16Z

[Term]
id: GO:0003232
name: bulbus arteriosus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the bulbus arteriosus over time, from its formation to the mature structure. The bulbus arteriosus is an elastic heart chamber." [GOC:mtg_heart]
is_a: GO:0003205 ! cardiac chamber development
created_by: dph
creation_date: 2009-10-13T11:05:36Z

[Term]
id: GO:0003233
name: bulbus arteriosus morphogenesis
namespace: biological_process
def: "The process in which the bulbus arteriosus is generated and organized. The bulbus arteriosus is an elastic cardiac chamber." [GOC:mtg_heart]
is_a: GO:0003206 ! cardiac chamber morphogenesis
relationship: part_of GO:0003232 ! bulbus arteriosus development
created_by: dph
creation_date: 2009-10-13T11:07:30Z

[Term]
id: GO:0003234
name: bulbus arteriosus formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the bulbus arteriosus from unspecified parts. The bulbus arteriosus is an elastic chamber of the heart." [GOC:mtg_heart]
is_a: GO:0003207 ! cardiac chamber formation
relationship: part_of GO:0003233 ! bulbus arteriosus morphogenesis
created_by: dph
creation_date: 2009-10-13T11:10:02Z

[Term]
id: GO:0003235
name: sinus venosus development
namespace: biological_process
def: "The progression of the sinus venosus over time, from its formation to the mature structure. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart]
is_a: GO:0003205 ! cardiac chamber development
created_by: dph
creation_date: 2009-10-13T11:12:34Z

[Term]
id: GO:0003236
name: sinus venosus morphogenesis
namespace: biological_process
def: "The process in which the sinus venosus is generated and organized. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart]
is_a: GO:0003206 ! cardiac chamber morphogenesis
relationship: part_of GO:0003235 ! sinus venosus development
created_by: dph
creation_date: 2009-10-13T11:16:52Z

[Term]
id: GO:0003237
name: sinus venosus formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the sinus venosus from unspecified parts. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart]
is_a: GO:0003207 ! cardiac chamber formation
relationship: part_of GO:0003236 ! sinus venosus morphogenesis
created_by: dph
creation_date: 2009-10-13T11:18:34Z

[Term]
id: GO:0003238
name: conus arteriosus development
namespace: biological_process
def: "The progression of the conus arteriosus over time, from its formation to the mature structure. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk." [GOC:mtg_heart]
is_a: GO:0003205 ! cardiac chamber development
created_by: dph
creation_date: 2009-10-13T11:20:57Z

[Term]
id: GO:0003239
name: conus arteriosus morphogenesis
namespace: biological_process
def: "The process in which the conus arteriosus is generated and organized. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk." [GOC:mtg_heart]
is_a: GO:0003206 ! cardiac chamber morphogenesis
relationship: part_of GO:0003238 ! conus arteriosus development
created_by: dph
creation_date: 2009-10-13T11:25:04Z

[Term]
id: GO:0003240
name: conus arteriosus formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the conus arteriosus from unspecified parts. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk." [GOC:mtg_heart]
is_a: GO:0003207 ! cardiac chamber formation
relationship: part_of GO:0003239 ! conus arteriosus morphogenesis
created_by: dph
creation_date: 2009-10-13T11:25:47Z

[Term]
id: GO:0003241
name: growth involved in heart morphogenesis
namespace: biological_process
def: "Developmental growth that contributes to the shaping of the heart." [GOC:mtg_heart]
is_a: GO:0060560 ! developmental growth involved in morphogenesis
intersection_of: GO:0040007 ! growth
intersection_of: part_of GO:0003007 ! heart morphogenesis
relationship: part_of GO:0003007 ! heart morphogenesis
relationship: part_of GO:0060419 ! heart growth
created_by: dph
creation_date: 2009-10-13T11:28:46Z

[Term]
id: GO:0003242
name: cardiac chamber ballooning
namespace: biological_process
def: "The morphogenic growth in which the chambers of the heart expand in size, contributing to their shaping." [GOC:mtg_heart]
is_a: GO:0003241 ! growth involved in heart morphogenesis
relationship: part_of GO:0003206 ! cardiac chamber morphogenesis
created_by: dph
creation_date: 2009-10-13T11:30:30Z

[Term]
id: GO:0003243
name: circumferential growth involved in left ventricle morphogenesis
namespace: biological_process
def: "The morphogenetic growth in which the left ventricle grows expanding its external boundary." [GOC:mtg_heart, PMID:14709543]
is_a: GO:0003241 ! growth involved in heart morphogenesis
relationship: part_of GO:0003214 ! cardiac left ventricle morphogenesis
created_by: dph
creation_date: 2009-10-13T11:33:09Z

[Term]
id: GO:0003244
name: radial growth involved in right ventricle morphogenesis
namespace: biological_process
def: "The morphogenic growth in which the right ventricle grows along a radial axis." [GOC:mtg_heart]
is_a: GO:0003241 ! growth involved in heart morphogenesis
relationship: part_of GO:0003215 ! cardiac right ventricle morphogenesis
created_by: dph
creation_date: 2009-10-13T11:38:23Z

[Term]
id: GO:0003245
name: cardiac muscle tissue growth involved in heart morphogenesis
namespace: biological_process
def: "The developmental growth of cardiac muscle tissue that contributes to the shaping of the heart." [GOC:mtg_heart]
is_a: GO:0003241 ! growth involved in heart morphogenesis
is_a: GO:0055017 ! cardiac muscle tissue growth
intersection_of: GO:0055017 ! cardiac muscle tissue growth
intersection_of: part_of GO:0003007 ! heart morphogenesis
relationship: part_of GO:0003007 ! heart morphogenesis
relationship: part_of GO:0055008 ! cardiac muscle tissue morphogenesis
created_by: dph
creation_date: 2009-10-13T11:44:21Z

[Term]
id: GO:0003246
name: embryonic cardiac muscle cell growth involved in heart morphogenesis
namespace: biological_process
def: "The growth of a cardiac muscle cell during the embryonic period, that contributes to the shaping of the heart." [GOC:mtg_heart]
synonym: "embryonic cardiac muscle physiological hypertrophy" EXACT [GOC:mtg_heart]
is_a: GO:0003241 ! growth involved in heart morphogenesis
is_a: GO:0061049 ! cell growth involved in cardiac muscle cell development
relationship: part_of GO:0003245 ! cardiac muscle tissue growth involved in heart morphogenesis
created_by: dph
creation_date: 2009-10-13T11:46:23Z

[Term]
id: GO:0003247
name: post-embryonic cardiac muscle cell growth involved in heart morphogenesis
namespace: biological_process
def: "The growth of a cardiac muscle cell during the postembryonic period that contributes to the shaping of the heart." [GOC:mtg_heart]
is_a: GO:0003241 ! growth involved in heart morphogenesis
is_a: GO:0048588 ! developmental cell growth
relationship: part_of GO:0003245 ! cardiac muscle tissue growth involved in heart morphogenesis
created_by: dph
creation_date: 2009-10-13T11:50:29Z

[Term]
id: GO:0003248
name: heart capillary growth
namespace: biological_process
def: "The increase in heart capillaries that accompanies physiological hypertrophy of cardiac muscle." [GOC:mtg_heart]
is_a: GO:0048589 ! developmental growth
relationship: part_of GO:0060419 ! heart growth
relationship: part_of GO:0060976 ! coronary vasculature development
created_by: dph
creation_date: 2009-10-13T11:53:12Z

[Term]
id: GO:0003249
name: cell proliferation involved in heart valve morphogenesis
namespace: biological_process
def: "The multiplication or reproduction of cells that contributes to the shaping of a heart valve." [GOC:mtg_heart]
is_a: GO:0061323 ! cell proliferation involved in heart morphogenesis
is_a: GO:2000793 ! cell proliferation involved in heart valve development
intersection_of: GO:0008283 ! cell proliferation
intersection_of: part_of GO:0003179 ! heart valve morphogenesis
relationship: part_of GO:0003179 ! heart valve morphogenesis
created_by: dph
creation_date: 2009-10-13T01:59:19Z

[Term]
id: GO:0003250
name: regulation of cell proliferation involved in heart valve morphogenesis
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve." [GOC:mtg_heart]
is_a: GO:2000136 ! regulation of cell proliferation involved in heart morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003249 ! cell proliferation involved in heart valve morphogenesis
relationship: regulates GO:0003249 ! cell proliferation involved in heart valve morphogenesis
created_by: dph
creation_date: 2009-10-13T02:03:42Z

[Term]
id: GO:0003251
name: positive regulation of cell proliferation involved in heart valve morphogenesis
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve." [GOC:mtg_heart]
is_a: GO:0003250 ! regulation of cell proliferation involved in heart valve morphogenesis
is_a: GO:2000138 ! positive regulation of cell proliferation involved in heart morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003249 ! cell proliferation involved in heart valve morphogenesis
relationship: positively_regulates GO:0003249 ! cell proliferation involved in heart valve morphogenesis
created_by: dph
creation_date: 2009-10-13T02:07:20Z

[Term]
id: GO:0003252
name: negative regulation of cell proliferation involved in heart valve morphogenesis
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve." [GOC:mtg_heart]
is_a: GO:0003250 ! regulation of cell proliferation involved in heart valve morphogenesis
is_a: GO:2000137 ! negative regulation of cell proliferation involved in heart morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003249 ! cell proliferation involved in heart valve morphogenesis
relationship: negatively_regulates GO:0003249 ! cell proliferation involved in heart valve morphogenesis
created_by: dph
creation_date: 2009-10-13T02:10:39Z

[Term]
id: GO:0003253
name: cardiac neural crest cell migration involved in outflow tract morphogenesis
namespace: biological_process
def: "The orderly movement of a neural crest cell from one site to another that will contribute to the morphogenesis of the outflow tract." [GOC:mtg_heart]
is_a: GO:0001755 ! neural crest cell migration
is_a: GO:0060973 ! cell migration involved in heart development
intersection_of: GO:0001755 ! neural crest cell migration
intersection_of: part_of GO:0003151 ! outflow tract morphogenesis
relationship: part_of GO:0003151 ! outflow tract morphogenesis
relationship: part_of GO:0061309 ! cardiac neural crest cell development involved in outflow tract morphogenesis
created_by: dph
creation_date: 2009-10-13T02:14:16Z

[Term]
id: GO:0003254
name: regulation of membrane depolarization
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of membrane depolarization. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential, usually from negative to positive." [GOC:dph, GOC:tb]
is_a: GO:0042391 ! regulation of membrane potential
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:2000021 ! regulation of ion homeostasis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051899 ! membrane depolarization
relationship: regulates GO:0051899 ! membrane depolarization
created_by: tanyaberardini
creation_date: 2009-10-14T10:54:09Z

[Term]
id: GO:0003255
name: endocardial precursor cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of an endocardial precursor cell. A endocardial precursor cell is a cell that has been committed to a endocardial cell fate, but will undergo further cell divisions rather than terminally differentiate." [GOC:mtg_heart]
is_a: GO:0010002 ! cardioblast differentiation
created_by: dph
creation_date: 2009-10-15T12:09:43Z

[Term]
id: GO:0003256
name: regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of a myocardial precursor cell." [GOC:mtg_heart]
is_a: GO:1901213 ! regulation of transcription from RNA polymerase II promoter involved in heart development
intersection_of: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
intersection_of: part_of GO:0060379 ! cardiac muscle cell myoblast differentiation
relationship: part_of GO:0060379 ! cardiac muscle cell myoblast differentiation
created_by: dph
creation_date: 2009-10-15T01:01:25Z

[Term]
id: GO:0003257
name: positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of a myocardial precursor cell." [GOC:mtg_heart]
is_a: GO:0003256 ! regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
is_a: GO:1901228 ! positive regulation of transcription from RNA polymerase II promoter involved in heart development
intersection_of: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
intersection_of: part_of GO:0060379 ! cardiac muscle cell myoblast differentiation
relationship: part_of GO:0060379 ! cardiac muscle cell myoblast differentiation
created_by: dph
creation_date: 2009-10-15T01:07:25Z

[Term]
id: GO:0003258
name: regulation of transcription from RNA polymerase II promoter involved in endocardial precursor cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of an endocardial precursor cell." [GOC:mtg_heart]
is_a: GO:1901213 ! regulation of transcription from RNA polymerase II promoter involved in heart development
intersection_of: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
intersection_of: part_of GO:0003255 ! endocardial precursor cell differentiation
relationship: part_of GO:0003255 ! endocardial precursor cell differentiation
created_by: dph
creation_date: 2009-10-15T01:10:34Z

[Term]
id: GO:0003259
name: cardioblast anterior-lateral migration
namespace: biological_process
def: "The orderly movement of a cardioblast toward the head and laterally to form the heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]
is_a: GO:0003260 ! cardioblast migration
created_by: dph
creation_date: 2009-10-15T01:17:28Z

[Term]
id: GO:0003260
name: cardioblast migration
namespace: biological_process
def: "The orderly movement of a cardiac progenitor cell to form the heart field. Cardiac progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into cells of the heart. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]
is_a: GO:0060974 ! cell migration involved in heart formation
relationship: part_of GO:0060914 ! heart formation
created_by: dph
creation_date: 2009-10-15T01:52:25Z

[Term]
id: GO:0003261
name: cardiac muscle progenitor cell migration to the midline involved in heart field formation
namespace: biological_process
def: "The orderly movement of a myocardial progenitor cell toward the midline to form the heart field. Cardiac muscle progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into myocardial cells of the heart." [GOC:mtg_heart]
synonym: "myocardial progenitor cell midline convergence" EXACT [GOC:mtg_heart]
is_a: GO:0060975 ! cardioblast migration to the midline involved in heart field formation
created_by: dph
creation_date: 2009-10-15T01:57:55Z

[Term]
id: GO:0003262
name: endocardial progenitor cell migration to the midline involved in heart field formation
namespace: biological_process
def: "The orderly movement of an endocardial progenitor cell toward the midline to form the heart field. Cardiac muscle progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into endocardial cells of the heart." [GOC:mtg_heart]
is_a: GO:0060975 ! cardioblast migration to the midline involved in heart field formation
created_by: dph
creation_date: 2009-10-15T02:00:41Z

[Term]
id: GO:0003263
name: cardioblast proliferation
namespace: biological_process
def: "The multiplication or reproduction of cardioblasts, resulting in the expansion of the population in the heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]
is_a: GO:0061323 ! cell proliferation involved in heart morphogenesis
relationship: part_of GO:0060914 ! heart formation
created_by: dph
creation_date: 2009-10-15T02:13:05Z

[Term]
id: GO:0003264
name: regulation of cardioblast proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardioblast proliferation. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]
is_a: GO:0003156 ! regulation of organ formation
is_a: GO:2000136 ! regulation of cell proliferation involved in heart morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003263 ! cardioblast proliferation
relationship: regulates GO:0003263 ! cardioblast proliferation
created_by: dph
creation_date: 2009-10-15T02:19:37Z

[Term]
id: GO:0003265
name: regulation of primary heart field cardioblast proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardioblast proliferation in the primary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. In mammals the primary heart field gives rise to the left ventricle." [GOC:mtg_heart, GOC:rl]
synonym: "regulation of FHF cardioblast proliferation" EXACT [GOC:rl]
synonym: "regulation of first heart field cardiac proliferation" RELATED []
synonym: "regulation of first heart field cardioblast proliferation" EXACT [GOC:rl]
is_a: GO:0003264 ! regulation of cardioblast proliferation
created_by: dph
creation_date: 2009-10-15T02:25:26Z

[Term]
id: GO:0003266
name: regulation of secondary heart field cardioblast proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardioblast proliferation in the second heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. The secondary heart field is the region of the heart that will form the majority of the mesodermal component of the right ventricle, the arterial pole (outflow tract) and the venous pole (inflow tract)." [GOC:mtg_heart, GOC:rl, PMID:17276708]
synonym: "regulation of second heart field cardioblast proliferation" EXACT [GOC:dph]
synonym: "regulation of SHF cardioblast proliferation" EXACT [GOC:rl]
is_a: GO:0003264 ! regulation of cardioblast proliferation
created_by: dph
creation_date: 2009-10-15T02:26:15Z

[Term]
id: GO:0003267
name: canonical Wnt signaling pathway involved in positive regulation of secondary heart field cardioblast proliferation
namespace: biological_process
def: "A canonical Wnt signaling pathway that contributes to an increase in the frequency, or rate of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]
synonym: "canonical Wnt receptor signaling pathway involved in positive regulation of second heart field cardioblast proliferation" EXACT [GOC:dph]
synonym: "canonical Wnt receptor signaling pathway involved in positive regulation of secondary heart field cardioblast proliferation" EXACT []
synonym: "canonical Wnt receptor signalling pathway involved in positive regulation of secondary heart field cardioblast proliferation" EXACT [GOC:mah]
synonym: "canonical Wnt-activated signaling pathway involved in positive regulation of secondary heart field cardioblast proliferation" RELATED [GOC:signaling]
is_a: GO:0044340 ! canonical Wnt signaling pathway involved in regulation of cell proliferation
is_a: GO:0061316 ! canonical Wnt signaling pathway involved in heart development
intersection_of: GO:0061316 ! canonical Wnt signaling pathway involved in heart development
intersection_of: part_of GO:0072513 ! positive regulation of secondary heart field cardioblast proliferation
relationship: part_of GO:0072513 ! positive regulation of secondary heart field cardioblast proliferation
created_by: dph
creation_date: 2009-10-15T02:36:08Z

[Term]
id: GO:0003268
name: fibroblast growth factor receptor signaling pathway involved in regulation of secondary heart field cardioblast proliferation
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands contributing to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]
synonym: "fibroblast growth factor receptor signaling pathway involved in regulation of second heart field cardioblast cell proliferation" EXACT [GOC:dph]
synonym: "fibroblast growth factor receptor signaling pathway involved in regulation of secondary heart field cardioblast cell proliferation" EXACT [GOC:bf]
synonym: "fibroblast growth factor receptor signalling pathway involved in regulation of secondary heart field cardioblast cell proliferation" EXACT [GOC:mah]
is_a: GO:0061313 ! fibroblast growth factor receptor signaling pathway involved in heart development
intersection_of: GO:0061313 ! fibroblast growth factor receptor signaling pathway involved in heart development
intersection_of: part_of GO:0003266 ! regulation of secondary heart field cardioblast proliferation
relationship: part_of GO:0003266 ! regulation of secondary heart field cardioblast proliferation
created_by: dph
creation_date: 2009-10-15T02:43:03Z

[Term]
id: GO:0003269
name: BMP signaling pathway involved in regulation of secondary heart field cardioblast proliferation
namespace: biological_process
def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]
synonym: "BMP signaling pathway involved in regulation of second heart field cardioblast proliferation" EXACT [GOC:dph]
synonym: "BMP signalling pathway involved in regulation of secondary heart field cardioblast proliferation" EXACT [GOC:mah]
is_a: GO:0061312 ! BMP signaling pathway involved in heart development
intersection_of: GO:0061312 ! BMP signaling pathway involved in heart development
intersection_of: part_of GO:0003266 ! regulation of secondary heart field cardioblast proliferation
relationship: part_of GO:0003266 ! regulation of secondary heart field cardioblast proliferation
created_by: dph
creation_date: 2009-10-15T02:45:28Z

[Term]
id: GO:0003270
name: Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation
namespace: biological_process
def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell contributing to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]
synonym: "Notch signaling pathway involved in regulation of second heart field cardioblast proliferation" RELATED [GOC:dph]
synonym: "Notch signalling pathway involved in regulation of secondary heart field cardioblast proliferation" EXACT [GOC:mah]
is_a: GO:0061314 ! Notch signaling involved in heart development
intersection_of: GO:0007219 ! Notch signaling pathway
intersection_of: part_of GO:0003266 ! regulation of secondary heart field cardioblast proliferation
relationship: part_of GO:0003266 ! regulation of secondary heart field cardioblast proliferation
created_by: dph
creation_date: 2009-10-15T02:47:00Z

[Term]
id: GO:0003271
name: smoothened signaling pathway involved in regulation of secondary heart field cardioblast proliferation
namespace: biological_process
def: "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened contributing to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]
synonym: "hedgehog signaling pathway involved in regulation of second heart field cardioblast proliferation" EXACT [GOC:bf, GOC:ecd]
synonym: "hh signaling pathway involved in regulation of second heart field cardioblast proliferation" EXACT [GOC:bf, GOC:ecd]
synonym: "smoothened receptor signaling pathway involved in regulation of second heart field cardioblast proliferation" EXACT [GOC:dph]
synonym: "smoothened receptor signaling pathway involved in regulation of secondary heart field cardioblast proliferation" EXACT [GOC:bf]
synonym: "smoothened receptor signalling pathway involved in regulation of secondary heart field cardioblast proliferation" EXACT [GOC:mah]
is_a: GO:0007224 ! smoothened signaling pathway
is_a: GO:0061311 ! cell surface receptor signaling pathway involved in heart development
intersection_of: GO:0007224 ! smoothened signaling pathway
intersection_of: part_of GO:0003266 ! regulation of secondary heart field cardioblast proliferation
relationship: part_of GO:0003266 ! regulation of secondary heart field cardioblast proliferation
created_by: dph
creation_date: 2009-10-15T02:48:32Z

[Term]
id: GO:0003272
name: endocardial cushion formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart, PMID:15797462]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0003203 ! endocardial cushion morphogenesis
created_by: dph
creation_date: 2009-10-20T08:53:19Z

[Term]
id: GO:0003273
name: cell migration involved in endocardial cushion formation
namespace: biological_process
def: "The orderly movement of a cell from one site to another that will contribute to the formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart]
is_a: GO:0060973 ! cell migration involved in heart development
intersection_of: GO:0016477 ! cell migration
intersection_of: part_of GO:0003272 ! endocardial cushion formation
relationship: part_of GO:0003272 ! endocardial cushion formation
created_by: dph
creation_date: 2009-10-20T09:08:44Z

[Term]
id: GO:0003274
name: endocardial cushion fusion
namespace: biological_process
def: "The cell-cell adhesion process of mesenchymal cardiac cushion cells that contributes to the process of cushion shaping." [GOC:mtg_heart]
is_a: GO:0016337 ! single organismal cell-cell adhesion
is_a: GO:0061343 ! cell adhesion involved in heart morphogenesis
is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules
intersection_of: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules
intersection_of: part_of GO:0003203 ! endocardial cushion morphogenesis
relationship: part_of GO:0003203 ! endocardial cushion morphogenesis
created_by: dph
creation_date: 2009-10-20T09:26:32Z

[Term]
id: GO:0003275
name: apoptotic process involved in outflow tract morphogenesis
namespace: biological_process
def: "Any apoptotic process that contributes to the shaping of the outflow tract. The outflow tract is the portion of the heart through which blood flows into the arteries." [GOC:mtg_apoptosis, GOC:mtg_heart]
synonym: "apoptosis involved in outflow tract morphogenesis" NARROW []
is_a: GO:0003278 ! apoptotic process involved in heart morphogenesis
intersection_of: GO:0006915 ! apoptotic process
intersection_of: part_of GO:0003151 ! outflow tract morphogenesis
relationship: part_of GO:0003151 ! outflow tract morphogenesis
created_by: dph
creation_date: 2009-10-20T09:30:01Z

[Term]
id: GO:0003276
name: apoptotic process involved in heart valve morphogenesis
namespace: biological_process
def: "Any apoptotic process that contributes to the shaping of a heart valve." [GOC:mtg_apoptosis, GOC:mtg_heart]
synonym: "apoptosis involved in heart valve morphogenesis" NARROW []
is_a: GO:0003278 ! apoptotic process involved in heart morphogenesis
intersection_of: GO:0006915 ! apoptotic process
intersection_of: part_of GO:0003179 ! heart valve morphogenesis
relationship: part_of GO:0003179 ! heart valve morphogenesis
created_by: dph
creation_date: 2009-10-20T09:34:29Z

[Term]
id: GO:0003277
name: apoptotic process involved in endocardial cushion morphogenesis
namespace: biological_process
def: "Any apoptotic process that contributes to the shaping of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_apoptosis, GOC:mtg_heart]
synonym: "apoptosis involved in endocardial cushion morphogenesis" NARROW []
is_a: GO:0003278 ! apoptotic process involved in heart morphogenesis
intersection_of: GO:0006915 ! apoptotic process
intersection_of: part_of GO:0003203 ! endocardial cushion morphogenesis
relationship: part_of GO:0003203 ! endocardial cushion morphogenesis
created_by: dph
creation_date: 2009-10-20T09:37:03Z

[Term]
id: GO:0003278
name: apoptotic process involved in heart morphogenesis
namespace: biological_process
def: "Any apoptotic process that contributes to the shaping of the heart." [GOC:mtg_apoptosis, GOC:mtg_heart]
synonym: "apoptosis involved in heart morphogenesis" NARROW []
is_a: GO:0060561 ! apoptotic process involved in morphogenesis
intersection_of: GO:0006915 ! apoptotic process
intersection_of: part_of GO:0003007 ! heart morphogenesis
relationship: part_of GO:0003007 ! heart morphogenesis
created_by: dph
creation_date: 2009-10-20T09:40:22Z

[Term]
id: GO:0003279
name: cardiac septum development
namespace: biological_process
def: "The progression of a cardiac septum over time, from its initial formation to the mature structure." [GOC:mtg_heart]
synonym: "heart septum development" EXACT [GOC:mtg_heart]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0003205 ! cardiac chamber development
created_by: dph
creation_date: 2009-10-20T09:45:13Z

[Term]
id: GO:0003281
name: ventricular septum development
namespace: biological_process
def: "The progression of the ventricular septum over time from its formation to the mature structure." [GOC:mtg_heart]
synonym: "interventricular septum development" EXACT [GOC:mtg_heart]
synonym: "septum inferius development" NARROW [GOC:mtg_heart]
is_a: GO:0003279 ! cardiac septum development
relationship: part_of GO:0003231 ! cardiac ventricle development
created_by: dph
creation_date: 2009-10-20T10:04:51Z

[Term]
id: GO:0003282
name: ventricular septum intermedium development
namespace: biological_process
def: "The progression of the ventricular septum intermedium over time, from its formation to the mature structure." [GOC:mtg_heart]
is_a: GO:0003281 ! ventricular septum development
created_by: dph
creation_date: 2009-10-20T10:09:53Z

[Term]
id: GO:0003283
name: atrial septum development
namespace: biological_process
def: "The progression of the atrial septum over time, from its initial formation to the mature structure." [GOC:mtg_heart]
is_a: GO:0003279 ! cardiac septum development
relationship: part_of GO:0003230 ! cardiac atrium development
created_by: dph
creation_date: 2009-10-20T10:10:38Z

[Term]
id: GO:0003284
name: septum primum development
namespace: biological_process
def: "The progression of the septum primum over time, from its formation to the mature structure." [GOC:mtg_heart]
is_a: GO:0003283 ! atrial septum development
created_by: dph
creation_date: 2009-10-20T10:12:26Z

[Term]
id: GO:0003285
name: septum secundum development
namespace: biological_process
def: "The progression of the septum secundum over time, from its initial formation to the mature structure." [GOC:mtg_heart]
is_a: GO:0003283 ! atrial septum development
created_by: dph
creation_date: 2009-10-20T10:21:13Z

[Term]
id: GO:0003286
name: atrial septum intermedium development
namespace: biological_process
def: "The progression of the atrial septum intermedium over time, from its formation to the mature structure." [GOC:mtg_heart]
is_a: GO:0003283 ! atrial septum development
created_by: dph
creation_date: 2009-10-20T10:23:52Z

[Term]
id: GO:0003288
name: ventricular septum intermedium morphogenesis
namespace: biological_process
def: "The developmental process in which a ventricular septum intermedium is generated and organized." [GOC:mtg_heart]
is_a: GO:0060412 ! ventricular septum morphogenesis
created_by: dph
creation_date: 2009-10-20T10:58:48Z

[Term]
id: GO:0003289
name: atrial septum primum morphogenesis
namespace: biological_process
def: "The process in which anatomical structure of an atrial septum primum is generated and organized." [GOC:mtg_heart]
is_a: GO:0060413 ! atrial septum morphogenesis
relationship: part_of GO:0003284 ! septum primum development
created_by: dph
creation_date: 2009-10-20T10:32:32Z

[Term]
id: GO:0003290
name: atrial septum secundum morphogenesis
namespace: biological_process
def: "The process in which anatomical structure of an atrial septum secundum is generated and organized." [GOC:mtg_heart]
is_a: GO:0060413 ! atrial septum morphogenesis
relationship: part_of GO:0003285 ! septum secundum development
created_by: dph
creation_date: 2009-10-20T10:33:57Z

[Term]
id: GO:0003291
name: atrial septum intermedium morphogenesis
namespace: biological_process
def: "The process in which anatomical structure of an atrial septum intermedium is generated and organized." [GOC:mtg_heart]
is_a: GO:0060413 ! atrial septum morphogenesis
relationship: part_of GO:0003286 ! atrial septum intermedium development
created_by: dph
creation_date: 2009-10-20T10:35:04Z

[Term]
id: GO:0003292
name: cardiac septum cell differentiation
namespace: biological_process
def: "The process in which an endocardial cushion cell becomes a cell of a cardiac septum." [GOC:mtg_heart]
is_a: GO:0035051 ! cardiocyte differentiation
relationship: part_of GO:0003279 ! cardiac septum development
created_by: dph
creation_date: 2009-10-20T11:03:46Z

[Term]
id: GO:0003293
name: heart valve cell differentiation
namespace: biological_process
def: "The process in which an endocardial cushion cell give rise to a cell that is part of a heart valve." [GOC:mtg_heart]
is_a: GO:0035051 ! cardiocyte differentiation
relationship: part_of GO:0003170 ! heart valve development
created_by: dph
creation_date: 2009-10-20T11:06:46Z

[Term]
id: GO:0003294
name: atrial ventricular junction remodeling
namespace: biological_process
def: "The reorganization or renovation of heart tissue that contributes to the maturation of the connection between an atrium and a ventricle." [GOC:mtg_heart]
synonym: "atrio-ventricular junction remodeling" RELATED [GOC:mtg_heart]
synonym: "atrioventricular junction remodeling" EXACT [GOC:mtg_heart]
is_a: GO:0048771 ! tissue remodeling
relationship: part_of GO:0003007 ! heart morphogenesis
created_by: dph
creation_date: 2009-10-22T08:35:36Z

[Term]
id: GO:0003295
name: cell proliferation involved in atrial ventricular junction remodeling
namespace: biological_process
def: "The multiplication or reproduction of cells that contributes to the reorganization of tissue resulting in the maturation of the atrial ventricular junction." [GOC:mtg_heart]
synonym: "cell proliferation involved in atrio-ventricular junction remodeling" EXACT [GOC:mtg_heart]
synonym: "cell proliferation involved in atrioventricular junction remodeling" EXACT [GOC:mtg_heart]
is_a: GO:0061323 ! cell proliferation involved in heart morphogenesis
intersection_of: GO:0008283 ! cell proliferation
intersection_of: part_of GO:0003294 ! atrial ventricular junction remodeling
relationship: part_of GO:0003294 ! atrial ventricular junction remodeling
created_by: dph
creation_date: 2009-10-22T08:38:30Z

[Term]
id: GO:0003296
name: apoptotic process involved in atrial ventricular junction remodeling
namespace: biological_process
def: "Any apoptotic process that contributes to the reorganization of tissue resulting in the maturation of the atrial ventricular junction." [GOC:mtg_apoptosis, GOC:mtg_heart]
synonym: "apoptosis involved in atrial ventricular junction remodeling" NARROW []
synonym: "apoptosis involved in atrio-ventricular junction remodeling" EXACT [GOC:mtg_heart]
synonym: "apoptosis involved in atrioventricular junction remodeling" EXACT [GOC:mtg_heart]
is_a: GO:0003278 ! apoptotic process involved in heart morphogenesis
intersection_of: GO:0006915 ! apoptotic process
intersection_of: part_of GO:0003294 ! atrial ventricular junction remodeling
relationship: part_of GO:0003294 ! atrial ventricular junction remodeling
created_by: dph
creation_date: 2009-10-22T08:43:11Z

[Term]
id: GO:0003297
name: heart wedging
namespace: biological_process
def: "The morphogenetic process in which the aorta inserts between the atrioventricular valves, contributing to the shaping of the heart." [GOC:mtg_heart]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0003007 ! heart morphogenesis
created_by: dph
creation_date: 2009-10-22T08:52:58Z

[Term]
id: GO:0003298
name: physiological muscle hypertrophy
namespace: biological_process
def: "The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development." [GOC:mtg_heart]
is_a: GO:0014896 ! muscle hypertrophy
created_by: dph
creation_date: 2009-10-22T09:24:51Z

[Term]
id: GO:0003299
name: muscle hypertrophy in response to stress
namespace: biological_process
def: "The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells as a result of a disturbance in organismal or cellular homeostasis." [GOC:mtg_heart]
is_a: GO:0006950 ! response to stress
is_a: GO:0014896 ! muscle hypertrophy
is_a: GO:0043500 ! muscle adaptation
created_by: dph
creation_date: 2009-10-22T09:26:10Z

[Term]
id: GO:0003300
name: cardiac muscle hypertrophy
namespace: biological_process
def: "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division." [GOC:mtg_heart]
is_a: GO:0014897 ! striated muscle hypertrophy
created_by: dph
creation_date: 2009-10-22T10:33:56Z

[Term]
id: GO:0003301
name: physiological cardiac muscle hypertrophy
namespace: biological_process
def: "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division. This process contributes to the developmental growth of the heart." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart]
is_a: GO:0003298 ! physiological muscle hypertrophy
is_a: GO:0003300 ! cardiac muscle hypertrophy
relationship: part_of GO:0055017 ! cardiac muscle tissue growth
created_by: dph
creation_date: 2009-10-22T10:38:10Z

[Term]
id: GO:0003302
name: transforming growth factor beta receptor signaling pathway involved in heart jogging
namespace: biological_process
def: "A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, which contributes to the process of heart jogging." [GOC:mtg_heart, GOC:signaling]
synonym: "transforming growth factor beta receptor signalling pathway involved in heart jogging" EXACT [GOC:mah]
is_a: GO:0035463 ! transforming growth factor beta receptor signaling pathway involved in determination of left/right asymmetry
is_a: GO:0061311 ! cell surface receptor signaling pathway involved in heart development
intersection_of: GO:0007179 ! transforming growth factor beta receptor signaling pathway
intersection_of: part_of GO:0003146 ! heart jogging
relationship: part_of GO:0003146 ! heart jogging
created_by: dph
creation_date: 2009-10-22T10:51:58Z

[Term]
id: GO:0003303
name: BMP signaling pathway involved in heart jogging
namespace: biological_process
def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the process of heart jogging." [GOC:mtg_heart]
synonym: "BMP signalling pathway involved in heart jogging" EXACT [GOC:mah]
is_a: GO:0003154 ! BMP signaling pathway involved in determination of left/right symmetry
is_a: GO:0061312 ! BMP signaling pathway involved in heart development
intersection_of: GO:0030509 ! BMP signaling pathway
intersection_of: part_of GO:0003146 ! heart jogging
relationship: part_of GO:0003146 ! heart jogging
created_by: dph
creation_date: 2009-10-22T11:00:58Z

[Term]
id: GO:0003304
name: myocardial epithelial involution involved in heart jogging
namespace: biological_process
def: "The morphogenetic process in which the myocardium bends along a linear axis and contributes to the process of heart jogging." [GOC:mtg_heart]
is_a: GO:0060571 ! morphogenesis of an epithelial fold
relationship: part_of GO:0003146 ! heart jogging
created_by: dph
creation_date: 2009-10-22T11:03:33Z

[Term]
id: GO:0003305
name: cell migration involved in heart jogging
namespace: biological_process
def: "The orderly movement of a cell of the myocardium from one site to another that will contribute to heart jogging." [GOC:mtg_heart]
is_a: GO:0060973 ! cell migration involved in heart development
intersection_of: GO:0016477 ! cell migration
intersection_of: part_of GO:0003146 ! heart jogging
relationship: part_of GO:0003146 ! heart jogging
created_by: dph
creation_date: 2009-10-22T11:05:46Z

[Term]
id: GO:0003306
name: Wnt signaling pathway involved in heart development
namespace: biological_process
def: "The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time." [GOC:mtg_heart]
synonym: "Wnt receptor signaling pathway involved in heart development" EXACT []
synonym: "Wnt receptor signalling pathway involved in heart development" EXACT [GOC:mah]
synonym: "Wnt-activated signaling pathway involved in heart development" EXACT [GOC:signaling]
is_a: GO:0016055 ! Wnt signaling pathway
is_a: GO:0061311 ! cell surface receptor signaling pathway involved in heart development
intersection_of: GO:0016055 ! Wnt signaling pathway
intersection_of: part_of GO:0007507 ! heart development
relationship: part_of GO:0007507 ! heart development
created_by: dph
creation_date: 2009-10-22T12:26:07Z

[Term]
id: GO:0003307
name: regulation of Wnt signaling pathway involved in heart development
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time." [GOC:mtg_heart]
synonym: "regulation of Wnt receptor signaling pathway involved in heart development" EXACT []
synonym: "regulation of Wnt receptor signalling pathway involved in heart development" EXACT [GOC:mah]
synonym: "regulation of Wnt-activated signaling pathway involved in heart development" EXACT [GOC:signaling]
is_a: GO:0030111 ! regulation of Wnt signaling pathway
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003306 ! Wnt signaling pathway involved in heart development
relationship: regulates GO:0003306 ! Wnt signaling pathway involved in heart development
created_by: dph
creation_date: 2009-10-22T12:32:10Z

[Term]
id: GO:0003308
name: negative regulation of Wnt signaling pathway involved in heart development
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time." [GOC:mtg_heart]
synonym: "negative regulation of Wnt receptor signaling pathway involved in heart development" EXACT []
synonym: "negative regulation of Wnt receptor signalling pathway involved in heart development" EXACT [GOC:mah]
synonym: "negative regulation of Wnt-activated signaling pathway involved in heart development" EXACT [GOC:signaling]
is_a: GO:0003307 ! regulation of Wnt signaling pathway involved in heart development
is_a: GO:0030178 ! negative regulation of Wnt signaling pathway
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003306 ! Wnt signaling pathway involved in heart development
relationship: negatively_regulates GO:0003306 ! Wnt signaling pathway involved in heart development
created_by: dph
creation_date: 2009-10-22T12:36:11Z

[Term]
id: GO:0003309
name: type B pancreatic cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:dph, PMID:11076772]
synonym: "pancreatic B cell differentiation" EXACT [GOC:mah]
synonym: "pancreatic beta cell differentiation" EXACT [GOC:dph]
is_a: GO:0035883 ! enteroendocrine cell differentiation
relationship: part_of GO:0031018 ! endocrine pancreas development
created_by: dph
creation_date: 2009-10-26T09:27:23Z

[Term]
id: GO:0003310
name: pancreatic A cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon." [GOC:dph, PMID:11076772]
synonym: "pancreatic alpha cell differentiation" EXACT [GOC:dph]
is_a: GO:0035883 ! enteroendocrine cell differentiation
relationship: part_of GO:0031018 ! endocrine pancreas development
created_by: dph
creation_date: 2009-10-26T09:28:05Z

[Term]
id: GO:0003311
name: pancreatic D cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and functional features that characterize a pancreatic delta cell. A delta cell is a cell of the pancreas that produces somatostatin." [GOC:dph, PMID:11076772]
synonym: "pancreatic delta cell differentiation" EXACT [GOC:dph]
is_a: GO:0035883 ! enteroendocrine cell differentiation
relationship: part_of GO:0031018 ! endocrine pancreas development
created_by: dph
creation_date: 2009-10-26T09:30:27Z

[Term]
id: GO:0003312
name: pancreatic PP cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic polypeptide-producing cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide." [GOC:dph, PMID:11076772]
synonym: "pancreatic polypeptide-producing cell differentiation" EXACT [GOC:dph]
is_a: GO:0035883 ! enteroendocrine cell differentiation
relationship: part_of GO:0031018 ! endocrine pancreas development
created_by: dph
creation_date: 2009-10-26T09:32:32Z

[Term]
id: GO:0003313
name: heart rudiment development
namespace: biological_process
def: "The progression of the heart rudiment over time, from its initial formation to the mature structure. The heart rudiment is a cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube." [GOC:mtg_heart]
synonym: "heart cone development" EXACT [GOC:mtg_heart]
is_a: GO:0060429 ! epithelium development
relationship: part_of GO:0035050 ! embryonic heart tube development
created_by: dph
creation_date: 2009-10-27T08:32:40Z

[Term]
id: GO:0003314
name: heart rudiment morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the heart rudiment are generated and organized." [GOC:mtg_heart]
synonym: "heart cone morphogenesis" EXACT [GOC:mtg_heart]
is_a: GO:0002009 ! morphogenesis of an epithelium
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0003313 ! heart rudiment development
created_by: dph
creation_date: 2009-10-27T08:38:04Z

[Term]
id: GO:0003315
name: heart rudiment formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the heart rudiment." [GOC:mtg_heart]
synonym: "heart cone formation" EXACT [GOC:mtg_heart]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0003314 ! heart rudiment morphogenesis
created_by: dph
creation_date: 2009-10-27T08:43:37Z

[Term]
id: GO:0003316
name: establishment of myocardial progenitor cell apical/basal polarity
namespace: biological_process
def: "The specification and formation of the apicobasal polarity of an myocardial progenitor cell that contributes to the formation of the heart rudiment." [GOC:mtg_heart]
synonym: "myocardial progenitor epithelial polarization" EXACT [GOC:mtg_heart]
is_a: GO:0045198 ! establishment of epithelial cell apical/basal polarity
relationship: part_of GO:0003315 ! heart rudiment formation
created_by: dph
creation_date: 2009-10-27T09:01:26Z

[Term]
id: GO:0003317
name: cardioblast cell midline fusion
namespace: biological_process
def: "The attachment of cardiac progenitor cells to one another that contributes to the formation of the heart rudiment." [GOC:mtg_heart]
synonym: "cardiac progenitor cell midline fusion" EXACT [GOC:mtg_heart]
is_a: GO:0034109 ! homotypic cell-cell adhesion
relationship: part_of GO:0003315 ! heart rudiment formation
created_by: dph
creation_date: 2009-10-27T09:08:57Z

[Term]
id: GO:0003318
name: cell migration to the midline involved in heart development
namespace: biological_process
def: "The orderly movement of a cell toward the midline that contributes to the progression of the heart over time." [GOC:mtg_heart]
is_a: GO:0060973 ! cell migration involved in heart development
created_by: dph
creation_date: 2009-10-27T09:15:43Z

[Term]
id: GO:0003319
name: cardioblast migration to the midline involved in heart rudiment formation
namespace: biological_process
def: "The orderly movement of a cardioblast toward the midline that contributes to the initial appearance of the heart rudiment." [GOC:mtg_heart]
is_a: GO:0003318 ! cell migration to the midline involved in heart development
relationship: part_of GO:0003315 ! heart rudiment formation
created_by: dph
creation_date: 2009-10-27T09:21:36Z

[Term]
id: GO:0003320
name: heart rudiment involution
namespace: biological_process
def: "The inward folding of myocardial tissue derived from the right half of the heart rudiment that will form the future ventral part of the heart tube." [GOC:mtg_heart]
is_a: GO:0003152 ! morphogenesis of an epithelial fold involved in embryonic heart tube formation
created_by: dph
creation_date: 2009-10-27T09:29:24Z

[Term]
id: GO:0003321
name: positive regulation of blood pressure by epinephrine-norepinephrine
namespace: biological_process
def: "Any process in which the force of blood traveling through the circulatory system is increased by the chemicals epinephrine and norepinephrine." [GOC:dph]
is_a: GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine
is_a: GO:0045777 ! positive regulation of blood pressure
created_by: dph
creation_date: 2009-10-29T01:52:50Z

[Term]
id: GO:0003322
name: pancreatic A cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a pancreatic A cell over time, from its formation to the mature structure. A pancreatic A cell is a cell in the pancreas that secretes glucagon." [GOC:dph]
synonym: "pancreatic alpha cell development" EXACT [GOC:dph]
is_a: GO:0002068 ! glandular epithelial cell development
relationship: part_of GO:0003310 ! pancreatic A cell differentiation
created_by: dph
creation_date: 2009-11-02T08:13:55Z

[Term]
id: GO:0003323
name: type B pancreatic cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:dph]
synonym: "pancreatic B cell development" EXACT [GOC:mah]
synonym: "pancreatic beta cell development" EXACT [GOC:dph]
is_a: GO:0002068 ! glandular epithelial cell development
relationship: part_of GO:0003309 ! type B pancreatic cell differentiation
created_by: dph
creation_date: 2009-11-02T08:20:11Z

[Term]
id: GO:0003324
name: pancreatic D cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a pancreatic delta cell over time, from its formation to the mature structure. A delta cell is a cell of the pancreas that produces somatostatin." [GOC:dph]
synonym: "pancreatic delta cell development" EXACT [GOC:dph]
is_a: GO:0002068 ! glandular epithelial cell development
relationship: part_of GO:0003311 ! pancreatic D cell differentiation
created_by: dph
creation_date: 2009-11-02T08:23:26Z

[Term]
id: GO:0003325
name: pancreatic PP cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a pancreatic PP cell over time, from its formation to the mature structure. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide." [GOC:dph]
is_a: GO:0002068 ! glandular epithelial cell development
relationship: part_of GO:0003312 ! pancreatic PP cell differentiation
created_by: dph
creation_date: 2009-11-02T08:25:03Z

[Term]
id: GO:0003326
name: pancreatic A cell fate commitment
namespace: biological_process
def: "The commitment of a cell to a pancreatic A cell and its capacity to differentiate into a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon." [GOC:dph]
is_a: GO:0072148 ! epithelial cell fate commitment
relationship: part_of GO:0003310 ! pancreatic A cell differentiation
created_by: dph
creation_date: 2009-11-02T08:29:00Z

[Term]
id: GO:0003327
name: type B pancreatic cell fate commitment
namespace: biological_process
def: "The commitment of a cell to a type B pancreatic cell fate and its capacity to differentiate into a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:dph]
synonym: "pancreatic B cell fate commitment" EXACT [GOC:mah]
is_a: GO:0072148 ! epithelial cell fate commitment
relationship: part_of GO:0003309 ! type B pancreatic cell differentiation
created_by: dph
creation_date: 2009-11-02T08:31:24Z

[Term]
id: GO:0003328
name: pancreatic D cell fate commitment
namespace: biological_process
def: "The commitment of a cell to a pancreatic D cell fate and its capacity to differentiate into a pancreatic D cell. A delta cell is a cell of the pancreas that produces somatostatin." [GOC:dph]
is_a: GO:0072148 ! epithelial cell fate commitment
relationship: part_of GO:0003311 ! pancreatic D cell differentiation
created_by: dph
creation_date: 2009-11-02T08:33:36Z

[Term]
id: GO:0003329
name: pancreatic PP cell fate commitment
namespace: biological_process
def: "The commitment of a cell to a pancreatic PP cell fate and its capacity to differentiate into a pancreatic PP cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide." [GOC:dph]
is_a: GO:0072148 ! epithelial cell fate commitment
relationship: part_of GO:0003312 ! pancreatic PP cell differentiation
created_by: dph
creation_date: 2009-11-02T08:35:13Z

[Term]
id: GO:0003330
name: regulation of extracellular matrix constituent secretion
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." [GOC:dph, GOC:tb]
is_a: GO:1903053 ! regulation of extracellular matrix organization
is_a: GO:1903530 ! regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070278 ! extracellular matrix constituent secretion
relationship: regulates GO:0070278 ! extracellular matrix constituent secretion
created_by: dph
creation_date: 2009-11-02T02:07:40Z

[Term]
id: GO:0003331
name: positive regulation of extracellular matrix constituent secretion
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." [GOC:dph, GOC:tb]
is_a: GO:0003330 ! regulation of extracellular matrix constituent secretion
is_a: GO:1903055 ! positive regulation of extracellular matrix organization
is_a: GO:1903532 ! positive regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070278 ! extracellular matrix constituent secretion
relationship: positively_regulates GO:0070278 ! extracellular matrix constituent secretion
created_by: dph
creation_date: 2009-11-02T02:11:22Z

[Term]
id: GO:0003332
name: negative regulation of extracellular matrix constituent secretion
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." [GOC:dph, GOC:tb]
is_a: GO:0003330 ! regulation of extracellular matrix constituent secretion
is_a: GO:1903054 ! negative regulation of extracellular matrix organization
is_a: GO:1903531 ! negative regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070278 ! extracellular matrix constituent secretion
relationship: negatively_regulates GO:0070278 ! extracellular matrix constituent secretion
created_by: dph
creation_date: 2009-11-02T02:13:49Z

[Term]
id: GO:0003333
name: amino acid transmembrane transport
namespace: biological_process
def: "The directed movement of amino acids, organic acids containing one or more amino substituents across a membrane by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "amino acid membrane transport" EXACT []
is_a: GO:0006865 ! amino acid transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport
created_by: dph
creation_date: 2009-11-02T02:36:11Z

[Term]
id: GO:0003334
name: keratinocyte development
namespace: biological_process
def: "The process whose specific outcome is the progression of a keratinocyte over time, from its formation to the mature structure." [GOC:dph]
is_a: GO:0002064 ! epithelial cell development
relationship: part_of GO:0030216 ! keratinocyte differentiation
created_by: dph
creation_date: 2009-11-24T08:55:57Z

[Term]
id: GO:0003335
name: corneocyte development
namespace: biological_process
def: "The process whose specific outcome is the progression of the corneocyte over time, from its formation to the mature structure. A corneocyte is the last stage of development of a keratinocyte where the keratinocyte flattens, loses its nucleus and eventually delaminates from the epidermis." [GOC:dph]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0003334 ! keratinocyte development
created_by: dph
creation_date: 2009-11-24T09:01:02Z

[Term]
id: GO:0003336
name: corneocyte desquamation
namespace: biological_process
def: "The delamination process that results in the shedding of a corneocyte from the surface of the epidermis." [GOC:dph]
synonym: "epidermal desquamation" EXACT [GOC:dph]
is_a: GO:0060232 ! delamination
relationship: part_of GO:0003335 ! corneocyte development
created_by: dph
creation_date: 2009-11-24T09:11:53Z

[Term]
id: GO:0003337
name: mesenchymal to epithelial transition involved in metanephros morphogenesis
namespace: biological_process
def: "A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros." [GOC:dph, GOC:yaf]
synonym: "metanephric mesenchyme to epithelial transition" RELATED [GOC:dph]
is_a: GO:0060231 ! mesenchymal to epithelial transition
intersection_of: GO:0060231 ! mesenchymal to epithelial transition
intersection_of: part_of GO:0003338 ! metanephros morphogenesis
relationship: part_of GO:0003338 ! metanephros morphogenesis
relationship: part_of GO:0072283 ! metanephric renal vesicle morphogenesis
created_by: dph
creation_date: 2009-11-24T09:29:49Z

[Term]
id: GO:0003338
name: metanephros morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the metanephros are generated and organized." [GOC:dph, GOC:yaf]
is_a: GO:0060993 ! kidney morphogenesis
relationship: part_of GO:0001656 ! metanephros development
created_by: dph
creation_date: 2009-11-24T09:32:09Z

[Term]
id: GO:0003339
name: regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros." [GOC:dph]
is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation
is_a: GO:0030856 ! regulation of epithelial cell differentiation
is_a: GO:0072215 ! regulation of metanephros development
is_a: GO:2000027 ! regulation of organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003337 ! mesenchymal to epithelial transition involved in metanephros morphogenesis
relationship: regulates GO:0003337 ! mesenchymal to epithelial transition involved in metanephros morphogenesis
created_by: dph
creation_date: 2009-11-24T09:43:04Z

[Term]
id: GO:0003340
name: negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros." [GOC:dph, GOC:yaf]
is_a: GO:0003339 ! regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
is_a: GO:0010771 ! negative regulation of cell morphogenesis involved in differentiation
is_a: GO:0030857 ! negative regulation of epithelial cell differentiation
is_a: GO:0072217 ! negative regulation of metanephros development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003337 ! mesenchymal to epithelial transition involved in metanephros morphogenesis
relationship: negatively_regulates GO:0003337 ! mesenchymal to epithelial transition involved in metanephros morphogenesis
created_by: dph
creation_date: 2009-11-24T09:46:12Z

[Term]
id: GO:0003341
name: cilium movement
namespace: biological_process
alt_id: GO:0036142
def: "The directed, self-propelled movement of a cilium." [GOC:dph, GOC:jl]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.
synonym: "ciliary motility" RELATED []
synonym: "cilium beating" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "flagellar motility" RELATED []
synonym: "flagellar movement" NARROW [GOC:bf]
synonym: "flagellum movement" NARROW []
synonym: "microtubule-based flagellum movement" EXACT []
is_a: GO:0007018 ! microtubule-based movement
created_by: dph
creation_date: 2009-11-24T09:56:26Z

[Term]
id: GO:0003342
name: proepicardium development
namespace: biological_process
def: "The progression of the proepicardium from its formation to the mature structure. The proepicardium is an outpouching of the septum transversum." [GOC:dph, PMID:18722343]
is_a: GO:0060485 ! mesenchyme development
relationship: part_of GO:0003343 ! septum transversum development
created_by: dph
creation_date: 2009-12-01T10:30:17Z

[Term]
id: GO:0003343
name: septum transversum development
namespace: biological_process
def: "The progression of the septum transversum from its initial formation to the mature structure. The septum transversum is a portion of the trunk mesenchyme." [GOC:dph, PMID:18722343]
is_a: GO:0060485 ! mesenchyme development
created_by: dph
creation_date: 2009-12-01T10:40:17Z

[Term]
id: GO:0003344
name: pericardium morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the pericardium is generated and organized." [GOC:dph, PMID:18722343]
is_a: GO:0002011 ! morphogenesis of an epithelial sheet
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0060039 ! pericardium development
created_by: dph
creation_date: 2009-12-01T10:46:34Z

[Term]
id: GO:0003345
name: proepicardium cell migration involved in pericardium morphogenesis
namespace: biological_process
def: "The coordinated movement of a mesenchymal proepicardial cell to the surface of the developing heart." [GOC:dph, PMID:18722343]
is_a: GO:0060973 ! cell migration involved in heart development
relationship: part_of GO:0003344 ! pericardium morphogenesis
created_by: dph
creation_date: 2009-12-01T10:49:32Z

[Term]
id: GO:0003346
name: epicardium-derived cell migration to the myocardium
namespace: biological_process
def: "The orderly movement of a cell that have undergone an epithelial to mesenchymal transition from the epicardium into the myocardium." [GOC:dph, PMID:18722343]
is_a: GO:0060973 ! cell migration involved in heart development
created_by: dph
creation_date: 2009-12-01T11:00:42Z

[Term]
id: GO:0003347
name: epicardial cell to mesenchymal cell transition
namespace: biological_process
def: "A transition where an epicardial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. The epicardium is a part of the pericardium." [GOC:dph, PMID:18722343]
is_a: GO:0001837 ! epithelial to mesenchymal transition
created_by: dph
creation_date: 2009-12-01T11:05:39Z

[Term]
id: GO:0003348
name: cardiac endothelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac endothelial cell." [GOC:dph, PMID:18722343]
is_a: GO:0035051 ! cardiocyte differentiation
is_a: GO:0045446 ! endothelial cell differentiation
created_by: dph
creation_date: 2009-12-01T11:12:05Z

[Term]
id: GO:0003349
name: epicardium-derived cardiac endothelial cell differentiation
namespace: biological_process
def: "The process in which an epicardial cell acquires the specialized structural and/or functional features of a cardiac endothelial cell." [GOC:dph, PMID:18722343]
is_a: GO:0003348 ! cardiac endothelial cell differentiation
created_by: dph
creation_date: 2009-12-01T11:17:49Z

[Term]
id: GO:0003350
name: pulmonary myocardium development
namespace: biological_process
def: "The progression of the pulmonary myocardium over time, from its initial formation to the mature structure. The pulmonary myocardium is the myocardial tissue present in the pulmonary vein." [GOC:dph, PMID:17638577]
is_a: GO:0014706 ! striated muscle tissue development
relationship: part_of GO:0060841 ! venous blood vessel development
created_by: dph
creation_date: 2009-12-01T12:50:06Z

[Term]
id: GO:0003351
name: epithelial cilium movement
namespace: biological_process
def: "The directed, self-propelled movement of a cilium of an epithelial cell. This movement is usually coordinated between many epithelial cells, and serves to move fluid." [GOC:dph]
synonym: "epithelial cilium beating" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003341 ! cilium movement
created_by: dph
creation_date: 2009-12-03T10:08:25Z

[Term]
id: GO:0003352
name: regulation of cilium movement
namespace: biological_process
alt_id: GO:1900172
def: "Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.
synonym: "regulation of flagellar movement" RELATED [GOC:TermGenie]
synonym: "regulation of flagellum movement" RELATED []
synonym: "regulation of microtubule-based flagellum movement" EXACT []
is_a: GO:0060632 ! regulation of microtubule-based movement
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003341 ! cilium movement
relationship: regulates GO:0003341 ! cilium movement
created_by: dph
creation_date: 2009-12-03T10:12:00Z

[Term]
id: GO:0003353
name: positive regulation of cilium movement
namespace: biological_process
alt_id: GO:1900174
def: "Any process that increases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.
synonym: "positive regulation of flagellar movement" RELATED [GOC:TermGenie]
synonym: "positive regulation of flagellum movement" RELATED []
synonym: "positive regulation of microtubule-based flagellum movement" EXACT []
is_a: GO:0003352 ! regulation of cilium movement
is_a: GO:0051272 ! positive regulation of cellular component movement
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003341 ! cilium movement
relationship: positively_regulates GO:0003341 ! cilium movement
created_by: dph
creation_date: 2009-12-03T10:16:10Z

[Term]
id: GO:0003354
name: negative regulation of cilium movement
namespace: biological_process
alt_id: GO:1900173
def: "Any process that decreases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.
synonym: "negative regulation of flagellum movement" RELATED []
synonym: "negative regulation of microtubule-based flagellum movement" EXACT []
is_a: GO:0003352 ! regulation of cilium movement
is_a: GO:0051271 ! negative regulation of cellular component movement
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003341 ! cilium movement
relationship: negatively_regulates GO:0003341 ! cilium movement
created_by: dph
creation_date: 2009-12-03T10:17:47Z

[Term]
id: GO:0003355
name: cilium movement involved in otolith formation
namespace: biological_process
def: "The directed, self-propelled movement of a cilium of an inner ear epithelial cell, resulting the aggregation of otolith seed particles." [GOC:dph]
is_a: GO:0003351 ! epithelial cilium movement
intersection_of: GO:0003341 ! cilium movement
intersection_of: part_of GO:0032475 ! otolith formation
relationship: part_of GO:0032475 ! otolith formation
created_by: dph
creation_date: 2009-12-03T10:21:08Z

[Term]
id: GO:0003356
name: regulation of cilium beat frequency
namespace: biological_process
alt_id: GO:0036144
def: "Any process that modulates the frequency of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.
synonym: "regulation of flagellum beat frequency" RELATED []
synonym: "regulation of microtubule-based flagellum beat frequency" EXACT []
is_a: GO:0003352 ! regulation of cilium movement
created_by: dph
creation_date: 2009-12-03T10:27:12Z

[Term]
id: GO:0003357
name: noradrenergic neuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron, a neuron that secretes noradrenaline." [GOC:dph]
synonym: "norepinephrine secreting neuron differentiation" EXACT [GOC:dph]
is_a: GO:0030182 ! neuron differentiation
created_by: dph
creation_date: 2009-12-03T10:34:30Z

[Term]
id: GO:0003358
name: noradrenergic neuron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a noradrenergic neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph]
synonym: "norepinephrine secreting neuron development" EXACT [GOC:dph]
is_a: GO:0048666 ! neuron development
relationship: part_of GO:0003357 ! noradrenergic neuron differentiation
created_by: dph
creation_date: 2009-12-03T10:38:37Z

[Term]
id: GO:0003359
name: noradrenergic neuron fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a noradrenergic neuron." [GOC:dph]
synonym: "norepinephrine secreting neuron fate commitment" EXACT [GOC:dph]
is_a: GO:0048663 ! neuron fate commitment
relationship: part_of GO:0003357 ! noradrenergic neuron differentiation
created_by: dph
creation_date: 2009-12-03T10:41:08Z

[Term]
id: GO:0003360
name: brainstem development
namespace: biological_process
def: "The progression of the brainstem from its formation to the mature structure. The brainstem is the part of the brain that connects the brain with the spinal cord." [GOC:dph]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
created_by: dph
creation_date: 2009-12-03T10:47:20Z

[Term]
id: GO:0003361
name: noradrenergic neuron differentiation involved in brainstem development
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron that is part of the brainstem." [GOC:dph]
is_a: GO:0003357 ! noradrenergic neuron differentiation
intersection_of: GO:0003357 ! noradrenergic neuron differentiation
intersection_of: part_of GO:0003360 ! brainstem development
relationship: part_of GO:0003360 ! brainstem development
created_by: dph
creation_date: 2009-12-03T10:53:30Z

[Term]
id: GO:0003362
name: noradrenergic neuron fate commitment involved in brainstem development
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a noradrenergic neuron that is part of the brainstem." [GOC:dph]
is_a: GO:0003359 ! noradrenergic neuron fate commitment
intersection_of: GO:0003359 ! noradrenergic neuron fate commitment
intersection_of: part_of GO:0003360 ! brainstem development
relationship: part_of GO:0003360 ! brainstem development
relationship: part_of GO:0003361 ! noradrenergic neuron differentiation involved in brainstem development
created_by: dph
creation_date: 2009-12-03T10:56:16Z

[Term]
id: GO:0003363
name: lamellipodium assembly involved in ameboidal cell migration
namespace: biological_process
def: "Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell that contributes to the directed self propelled movement of a cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0030032 ! lamellipodium assembly
intersection_of: GO:0030032 ! lamellipodium assembly
intersection_of: part_of GO:0001667 ! ameboidal-type cell migration
relationship: part_of GO:0001667 ! ameboidal-type cell migration
created_by: dph
creation_date: 2009-12-08T04:38:04Z

[Term]
id: GO:0003364
name: lamellipodium assembly involved in mesendodermal cell migration
namespace: biological_process
def: "Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell that contributes to the directed self-propelled movement of a mesendodermal cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003363 ! lamellipodium assembly involved in ameboidal cell migration
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
intersection_of: GO:0030032 ! lamellipodium assembly
intersection_of: part_of GO:0090134 ! cell migration involved in mesendoderm migration
relationship: part_of GO:0090134 ! cell migration involved in mesendoderm migration
created_by: dph
creation_date: 2009-12-08T04:46:39Z

[Term]
id: GO:0003365
name: establishment of cell polarity involved in ameboidal cell migration
namespace: biological_process
def: "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0030010 ! establishment of cell polarity
intersection_of: GO:0030010 ! establishment of cell polarity
intersection_of: part_of GO:0001667 ! ameboidal-type cell migration
relationship: part_of GO:0001667 ! ameboidal-type cell migration
created_by: dph
creation_date: 2009-12-08T04:50:41Z

[Term]
id: GO:0003366
name: cell-matrix adhesion involved in ameboidal cell migration
namespace: biological_process
def: "The binding of a cell to the extracellular matrix that contributes to the directed movement of an ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0007160 ! cell-matrix adhesion
intersection_of: GO:0007160 ! cell-matrix adhesion
intersection_of: part_of GO:0001667 ! ameboidal-type cell migration
relationship: part_of GO:0001667 ! ameboidal-type cell migration
created_by: dph
creation_date: 2009-12-08T04:54:33Z

[Term]
id: GO:0003367
name: cell-cell adhesion involved in ameboidal cell migration
namespace: biological_process
def: "The attachment of one ameboid cell to another that contributes to the establishment of cell polarity that is part of the directed movement of one of the cells." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0016337 ! single organismal cell-cell adhesion
is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules
intersection_of: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules
intersection_of: part_of GO:0003365 ! establishment of cell polarity involved in ameboidal cell migration
relationship: part_of GO:0003365 ! establishment of cell polarity involved in ameboidal cell migration
created_by: dph
creation_date: 2009-12-08T05:15:49Z

[Term]
id: GO:0003368
name: cell-matrix adhesion involved in mesendodermal cell migration
namespace: biological_process
def: "The binding of a cell to the extracellular matrix that contributes to the directed movement of a mesendodermal cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003366 ! cell-matrix adhesion involved in ameboidal cell migration
intersection_of: GO:0007160 ! cell-matrix adhesion
intersection_of: part_of GO:0090134 ! cell migration involved in mesendoderm migration
relationship: part_of GO:0090134 ! cell migration involved in mesendoderm migration
created_by: dph
creation_date: 2009-12-08T05:26:12Z

[Term]
id: GO:0003369
name: establishment of cell polarity involved in mesendodermal cell migration
namespace: biological_process
def: "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of a mesendodermal cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003379 ! establishment of cell polarity involved in gastrulation cell migration
intersection_of: GO:0030010 ! establishment of cell polarity
intersection_of: part_of GO:0090134 ! cell migration involved in mesendoderm migration
relationship: part_of GO:0090134 ! cell migration involved in mesendoderm migration
created_by: dph
creation_date: 2009-12-08T05:31:51Z

[Term]
id: GO:0003370
name: cell-cell adhesion involved in mesendodermal cell migration
namespace: biological_process
def: "The attachment of mesendodermal cells to each other that contributes to the establishment of cell polarity that is part of the directed movement of the cells of the mesendoderm." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003367 ! cell-cell adhesion involved in ameboidal cell migration
is_a: GO:0070586 ! cell-cell adhesion involved in gastrulation
intersection_of: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules
intersection_of: part_of GO:0003369 ! establishment of cell polarity involved in mesendodermal cell migration
relationship: part_of GO:0003369 ! establishment of cell polarity involved in mesendodermal cell migration
created_by: dph
creation_date: 2009-12-08T05:33:51Z

[Term]
id: GO:0003371
name: establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0030952 ! establishment or maintenance of cytoskeleton polarity
intersection_of: GO:0030952 ! establishment or maintenance of cytoskeleton polarity
intersection_of: part_of GO:0001667 ! ameboidal-type cell migration
relationship: part_of GO:0001667 ! ameboidal-type cell migration
relationship: part_of GO:0003365 ! establishment of cell polarity involved in ameboidal cell migration
created_by: dph
creation_date: 2009-12-08T05:42:46Z

[Term]
id: GO:0003372
name: establishment or maintenance of cytoskeleton polarity involved in mesendodermal cell migration
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003380 ! establishment or maintenance of cytoskeleton polarity involved in gastrulation
intersection_of: GO:0030952 ! establishment or maintenance of cytoskeleton polarity
intersection_of: part_of GO:0090134 ! cell migration involved in mesendoderm migration
relationship: part_of GO:0003369 ! establishment of cell polarity involved in mesendodermal cell migration
relationship: part_of GO:0090134 ! cell migration involved in mesendoderm migration
created_by: dph
creation_date: 2009-12-08T05:46:23Z

[Term]
id: GO:0003373
name: dynamin polymerization involved in membrane fission
namespace: biological_process
def: "The process of creating dynamin polymers, compounds composed of a large number of dynamin monomers. Dynamin polymers form around lipid tubes and contribute to membrane fission." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0051258 ! protein polymerization
relationship: part_of GO:0090148 ! membrane fission
created_by: dph
creation_date: 2009-12-09T04:55:16Z

[Term]
id: GO:0003374
name: dynamin polymerization involved in mitochondrial fission
namespace: biological_process
def: "The process of creating dynamin polymers, compounds composed of a large number of dynamin monomers around a lipid tube of a dividing mitochondrion. Dynamin polymers form around lipid tubes and contribute to membrane fission." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003373 ! dynamin polymerization involved in membrane fission
created_by: dph
creation_date: 2009-12-09T05:39:52Z

[Term]
id: GO:0003375
name: regulation of dynamin polymerization involved in membrane fission
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of membrane fission." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0032271 ! regulation of protein polymerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003373 ! dynamin polymerization involved in membrane fission
relationship: regulates GO:0003373 ! dynamin polymerization involved in membrane fission
created_by: dph
creation_date: 2009-12-09T05:50:15Z

[Term]
id: GO:0003376
name: sphingosine-1-phosphate signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the sphingolipid sphingosine-1-phosphate (S1P) binding to a receptor on the surface of the cell, and which proceeds with the activated receptor transmitting the signal by promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:ascb_2009, GOC:signaling, PMID:22001186, Reactome:REACT_18416.2]
comment: Sphingosine-1-phosphate (S1P) can act both as an extracellular ligand for cell surface G-protein coupled receptors, and as an intracellular second messenger. GO:0003376 describes a pathway where S1P acts as an extracellular ligand. Where S1P acts within the cell to transmit a signal, consider instead 'intracellular signal transduction ; GO:0035556' or 'G-protein signaling, coupled to S1P second messenger (sphingosine kinase activating) ; GO:0001789'.
synonym: "S1P receptor signaling pathway" EXACT [GOC:bf]
synonym: "S1P signaling pathway" EXACT [GOC:bf]
synonym: "S1P-activated G-protein coupled receptor signaling pathway" EXACT [GOC:bf]
synonym: "S1P-activated GPCR signaling pathway" EXACT [GOC:bf]
synonym: "S1P-stimulated signal transduction pathway" EXACT [PMID:22001186]
synonym: "sphingolipid signaling pathway" BROAD [GOC:bf]
synonym: "sphingolipid signalling pathway" BROAD [GOC:mah]
synonym: "sphingosine-1-phosphate signal transduction" EXACT [GOC:signaling]
xref: Reactome:REACT_18416.2 "S1P-binding receptors bind S1P"
is_a: GO:0007186 ! G-protein coupled receptor signaling pathway
is_a: GO:0090520 ! sphingolipid mediated signaling pathway
created_by: dph
creation_date: 2009-12-09T06:30:12Z

[Term]
id: GO:0003377
name: regulation of apoptosis by sphingosine-1-phosphate signaling pathway
namespace: biological_process
def: "A sphingosine-1-phosphate signaling pathway that modulates the rate, frequency, or extent of apoptosis." [GOC:ascb_2009, GOC:dph, GOC:signaling, GOC:tb]
synonym: "regulation of apoptosis by sphingolipid signaling pathway" BROAD [GOC:bf]
synonym: "regulation of apoptosis by sphingolipid signalling pathway" BROAD [GOC:mah]
is_a: GO:0003376 ! sphingosine-1-phosphate signaling pathway
is_a: GO:0042981 ! regulation of apoptotic process
created_by: dph
creation_date: 2009-12-09T06:32:22Z

[Term]
id: GO:0003378
name: regulation of inflammatory response by sphingosine-1-phosphate signaling pathway
namespace: biological_process
def: "A sphingosine-1-phosphate signaling pathway that modulates the rate, frequency, or extent of the inflammatory response." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "regulation of inflammatory response by sphingolipid signaling pathway" BROAD [GOC:bf]
synonym: "regulation of inflammatory response by sphingolipid signalling pathway" BROAD [GOC:mah]
is_a: GO:0003376 ! sphingosine-1-phosphate signaling pathway
is_a: GO:0050727 ! regulation of inflammatory response
intersection_of: GO:0003376 ! sphingosine-1-phosphate signaling pathway
intersection_of: regulates GO:0006954 ! inflammatory response
relationship: regulates GO:0006954 ! inflammatory response
created_by: dph
creation_date: 2009-12-09T06:38:06Z

[Term]
id: GO:0003379
name: establishment of cell polarity involved in gastrulation cell migration
namespace: biological_process
def: "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell taking part in gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003365 ! establishment of cell polarity involved in ameboidal cell migration
intersection_of: GO:0030010 ! establishment of cell polarity
intersection_of: part_of GO:0042074 ! cell migration involved in gastrulation
relationship: part_of GO:0042074 ! cell migration involved in gastrulation
created_by: dph
creation_date: 2009-12-09T06:54:44Z

[Term]
id: GO:0003380
name: establishment or maintenance of cytoskeleton polarity involved in gastrulation
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell taking part in gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003371 ! establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration
intersection_of: GO:0030952 ! establishment or maintenance of cytoskeleton polarity
intersection_of: part_of GO:0007369 ! gastrulation
relationship: part_of GO:0003379 ! establishment of cell polarity involved in gastrulation cell migration
relationship: part_of GO:0007369 ! gastrulation
created_by: dph
creation_date: 2009-12-09T07:10:57Z

[Term]
id: GO:0003381
name: epithelial cell morphogenesis involved in gastrulation
namespace: biological_process
def: "The change in form that occurs when an epithelial cell progresses from it initial formation to its mature state, contributing to the process of gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003382 ! epithelial cell morphogenesis
intersection_of: GO:0003382 ! epithelial cell morphogenesis
intersection_of: part_of GO:0007369 ! gastrulation
relationship: part_of GO:0007369 ! gastrulation
created_by: dph
creation_date: 2009-12-09T07:18:53Z

[Term]
id: GO:0003382
name: epithelial cell morphogenesis
namespace: biological_process
def: "The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0000904 ! cell morphogenesis involved in differentiation
relationship: part_of GO:0002064 ! epithelial cell development
created_by: dph
creation_date: 2009-12-09T07:21:06Z

[Term]
id: GO:0003383
name: apical constriction
namespace: biological_process
def: "The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0070252 ! actin-mediated cell contraction
relationship: part_of GO:0003382 ! epithelial cell morphogenesis
created_by: dph
creation_date: 2009-12-09T07:30:34Z

[Term]
id: GO:0003384
name: apical constriction involved in gastrulation
namespace: biological_process
def: "The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell, contributing to the process of gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003383 ! apical constriction
intersection_of: GO:0003383 ! apical constriction
intersection_of: part_of GO:0007369 ! gastrulation
relationship: part_of GO:0003381 ! epithelial cell morphogenesis involved in gastrulation
relationship: part_of GO:0007369 ! gastrulation
created_by: dph
creation_date: 2009-12-09T07:35:38Z

[Term]
id: GO:0003385
name: cell-cell signaling involved in amphid sensory organ development
namespace: biological_process
def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of an amphid sensory organ over time, from its formation to the mature state." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "cell-cell signalling involved in amphid sensory organ development" EXACT [GOC:mah]
is_a: GO:0007267 ! cell-cell signaling
intersection_of: GO:0007267 ! cell-cell signaling
intersection_of: part_of GO:0003386 ! amphid sensory organ development
relationship: part_of GO:0003386 ! amphid sensory organ development
created_by: dph
creation_date: 2009-12-09T08:55:37Z

[Term]
id: GO:0003386
name: amphid sensory organ development
namespace: biological_process
def: "The progression of the amphid sensory organ over time, from its formation to the mature structure. Amphid sensory organs are the sensory organs of nematodes." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0007423 ! sensory organ development
created_by: dph
creation_date: 2009-12-09T09:09:20Z

[Term]
id: GO:0003387
name: neuron differentiation involved in amphid sensory organ development
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron that contributes to the progression of the amphid sensory gland." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0030182 ! neuron differentiation
intersection_of: GO:0030182 ! neuron differentiation
intersection_of: part_of GO:0003386 ! amphid sensory organ development
relationship: part_of GO:0003386 ! amphid sensory organ development
created_by: dph
creation_date: 2009-12-09T09:15:00Z

[Term]
id: GO:0003388
name: neuron development involved in amphid sensory organ development
namespace: biological_process
def: "The process whose specific outcome is the progression of a neuron over time, that contributes to the development of the amphid sensory organ." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0048666 ! neuron development
intersection_of: GO:0048666 ! neuron development
intersection_of: part_of GO:0003386 ! amphid sensory organ development
relationship: part_of GO:0003386 ! amphid sensory organ development
relationship: part_of GO:0003387 ! neuron differentiation involved in amphid sensory organ development
created_by: dph
creation_date: 2009-12-09T09:18:06Z

[Term]
id: GO:0003389
name: retrograde extension
namespace: biological_process
def: "The progression of a neuronal projection over time by the attachment of a part of the cell to an anchor and the subsequent migration of the cell body away from the anchor point." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0031175 ! neuron projection development
created_by: dph
creation_date: 2009-12-09T09:22:03Z

[Term]
id: GO:0003390
name: dendrite development by retrograde extension
namespace: biological_process
def: "The progression of a dendrite over time by the attachment of a part of the neuron to an anchor and the subsequent migration of the cell body away from the anchor point." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "dendrite retrograde extension" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003389 ! retrograde extension
is_a: GO:0016358 ! dendrite development
created_by: dph
creation_date: 2009-12-09T09:25:24Z

[Term]
id: GO:0003391
name: amphid sensory organ dendrite retrograde extension
namespace: biological_process
def: "The progression of an amphid sensory organ's neuronal dendrite over time by the attachment of a part of the cell to an anchor and the subsequent migration of the cell body away from the anchor point." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003390 ! dendrite development by retrograde extension
relationship: part_of GO:0003388 ! neuron development involved in amphid sensory organ development
created_by: dph
creation_date: 2009-12-09T09:28:27Z

[Term]
id: GO:0003392
name: cell adhesion involved in retrograde extension
namespace: biological_process
def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix that contributes to the process of retrograde extension." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0007155 ! cell adhesion
intersection_of: GO:0007155 ! cell adhesion
intersection_of: part_of GO:0003389 ! retrograde extension
relationship: part_of GO:0003389 ! retrograde extension
created_by: dph
creation_date: 2009-12-09T09:32:06Z

[Term]
id: GO:0003393
name: neuron migration involved in retrograde extension
namespace: biological_process
def: "The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0001764 ! neuron migration
intersection_of: GO:0001764 ! neuron migration
intersection_of: part_of GO:0003389 ! retrograde extension
relationship: part_of GO:0003389 ! retrograde extension
created_by: dph
creation_date: 2009-12-09T09:36:03Z

[Term]
id: GO:0003394
name: cell adhesion involved in dendrite retrograde extension
namespace: biological_process
def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix that contributes to the process of retrograde extension of a dendrite." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003392 ! cell adhesion involved in retrograde extension
intersection_of: GO:0007155 ! cell adhesion
intersection_of: part_of GO:0003390 ! dendrite development by retrograde extension
relationship: part_of GO:0003390 ! dendrite development by retrograde extension
created_by: dph
creation_date: 2009-12-09T09:42:09Z

[Term]
id: GO:0003395
name: neuron migration involved in dendrite retrograde extension
namespace: biological_process
def: "The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension of a dendrite." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003393 ! neuron migration involved in retrograde extension
intersection_of: GO:0001764 ! neuron migration
intersection_of: part_of GO:0003390 ! dendrite development by retrograde extension
relationship: part_of GO:0003390 ! dendrite development by retrograde extension
created_by: dph
creation_date: 2009-12-09T09:44:24Z

[Term]
id: GO:0003396
name: cell adhesion involved in amphid sensory organ dendrite retrograde extension
namespace: biological_process
def: "The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension of a dendrite in a neuron of the amphid sensory organ." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003394 ! cell adhesion involved in dendrite retrograde extension
intersection_of: GO:0007155 ! cell adhesion
intersection_of: part_of GO:0003391 ! amphid sensory organ dendrite retrograde extension
relationship: part_of GO:0003391 ! amphid sensory organ dendrite retrograde extension
created_by: dph
creation_date: 2009-12-09T09:50:18Z

[Term]
id: GO:0003397
name: neuron migration involved in amphid sensory organ dendrite retrograde extension
namespace: biological_process
def: "The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension of a dendrite of a neuron in the amphid sensory organ." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003395 ! neuron migration involved in dendrite retrograde extension
intersection_of: GO:0001764 ! neuron migration
intersection_of: part_of GO:0003391 ! amphid sensory organ dendrite retrograde extension
relationship: part_of GO:0003391 ! amphid sensory organ dendrite retrograde extension
created_by: dph
creation_date: 2009-12-09T09:52:18Z

[Term]
id: GO:0003398
name: glial cell differentiation involved in amphid sensory organ development
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a glial cell of the amphid sensory organ." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0010001 ! glial cell differentiation
intersection_of: GO:0010001 ! glial cell differentiation
intersection_of: part_of GO:0003386 ! amphid sensory organ development
relationship: part_of GO:0003386 ! amphid sensory organ development
created_by: dph
creation_date: 2009-12-09T09:55:27Z

[Term]
id: GO:0003399
name: cytoneme morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a cytoneme are shaped. A cytoneme is a long, thin and polarized actin-based cytoplasmic extension that projects from a cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0048858 ! cell projection morphogenesis
created_by: dph
creation_date: 2009-12-09T10:03:32Z

[Term]
id: GO:0003400
name: regulation of COPII vesicle coating
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb]
is_a: GO:0033043 ! regulation of organelle organization
is_a: GO:0043254 ! regulation of protein complex assembly
is_a: GO:0048209 ! regulation of vesicle targeting, to, from or within Golgi
is_a: GO:0090113 ! regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048208 ! COPII vesicle coating
relationship: regulates GO:0048208 ! COPII vesicle coating
created_by: dph
creation_date: 2009-12-17T08:38:14Z

[Term]
id: GO:0003401
name: axis elongation
namespace: biological_process
def: "The developmental growth that results in the elongation of a line that defines polarity or symmetry in an anatomical structure." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "elongation of an axis" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0060560 ! developmental growth involved in morphogenesis
created_by: dph
creation_date: 2009-12-21T01:12:15Z

[Term]
id: GO:0003402
name: planar cell polarity pathway involved in axis elongation
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal to modulate cytoskeletal elements and control cell polarity that contributes to axis elongation." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway
intersection_of: GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway
intersection_of: part_of GO:0003401 ! axis elongation
relationship: part_of GO:0003401 ! axis elongation
created_by: dph
creation_date: 2009-12-21T01:22:11Z

[Term]
id: GO:0003403
name: optic vesicle formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the optic vesicle from the lateral wall of the forebrain. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0003404 ! optic vesicle morphogenesis
relationship: part_of GO:0060900 ! embryonic camera-type eye formation
created_by: dph
creation_date: 2009-12-21T01:42:37Z

[Term]
id: GO:0003404
name: optic vesicle morphogenesis
namespace: biological_process
def: "The developmental process pertaining to the formation and shaping of the optic vesicle. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0048729 ! tissue morphogenesis
relationship: part_of GO:0048596 ! embryonic camera-type eye morphogenesis
created_by: dph
creation_date: 2009-12-21T01:54:34Z

[Term]
id: GO:0003405
name: optic vesicle elongation
namespace: biological_process
def: "The developmental growth that results in the lengthening of the optic vesicle in the posterior direction." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0003404 ! optic vesicle morphogenesis
created_by: dph
creation_date: 2009-12-21T01:59:50Z

[Term]
id: GO:0003406
name: retinal pigment epithelium development
namespace: biological_process
def: "The progression of the retinal pigment epithelium over time, from its initial formation to the mature structure. The retinal pigment epithelium is the melanin-containing layer of cells between the retina and the choroid that absorbs scattered and reflected light and removes waste products produced by the photoreceptor cells." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "RPE development" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0060429 ! epithelium development
relationship: part_of GO:0060041 ! retina development in camera-type eye
created_by: dph
creation_date: 2009-12-21T02:04:27Z

[Term]
id: GO:0003407
name: neural retina development
namespace: biological_process
def: "The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0060041 ! retina development in camera-type eye
created_by: dph
creation_date: 2009-12-21T02:15:14Z

[Term]
id: GO:0003408
name: optic cup formation involved in camera-type eye development
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the optic cup, a two-walled vesicle formed from the optic vesicle." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0002072 ! optic cup morphogenesis involved in camera-type eye development
created_by: dph
creation_date: 2009-12-21T02:37:12Z

[Term]
id: GO:0003409
name: optic cup structural organization
namespace: biological_process
def: "The process that contributes to creating the structural organization of the optic cup. This process pertains to the physical shaping of the rudimentary structure." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "optic cup structural organisation" EXACT [GOC:mah]
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0002072 ! optic cup morphogenesis involved in camera-type eye development
created_by: dph
creation_date: 2009-12-21T02:44:20Z

[Term]
id: GO:0003410
name: anterior rotation of the optic cup
namespace: biological_process
def: "A 90 degree-rotation of the optic cup resulting in its alignment with the anterior-posterior body axis." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0043010 ! camera-type eye development
created_by: dph
creation_date: 2009-12-21T02:49:48Z

[Term]
id: GO:0003411
name: cell motility involved in camera-type eye morphogenesis
namespace: biological_process
def: "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another and contributes to the physical shaping or formation of the camera-type eye." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0048870 ! cell motility
intersection_of: GO:0048870 ! cell motility
intersection_of: part_of GO:0048593 ! camera-type eye morphogenesis
relationship: part_of GO:0048593 ! camera-type eye morphogenesis
created_by: dph
creation_date: 2009-12-21T03:04:27Z

[Term]
id: GO:0003412
name: establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis
namespace: biological_process
def: "The specification and formation of the apicobasal polarity of an epithelial cell that contributes to the shaping of a camera-type eye." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0045198 ! establishment of epithelial cell apical/basal polarity
intersection_of: GO:0045198 ! establishment of epithelial cell apical/basal polarity
intersection_of: part_of GO:0048593 ! camera-type eye morphogenesis
relationship: part_of GO:0048593 ! camera-type eye morphogenesis
created_by: dph
creation_date: 2009-12-21T03:09:23Z

[Term]
id: GO:0003413
name: chondrocyte differentiation involved in endochondral bone morphogenesis
namespace: biological_process
def: "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0002062 ! chondrocyte differentiation
intersection_of: GO:0002062 ! chondrocyte differentiation
intersection_of: part_of GO:0060350 ! endochondral bone morphogenesis
relationship: part_of GO:0060350 ! endochondral bone morphogenesis
relationship: part_of GO:0060351 ! cartilage development involved in endochondral bone morphogenesis
created_by: dph
creation_date: 2009-12-22T08:39:58Z

[Term]
id: GO:0003414
name: chondrocyte morphogenesis involved in endochondral bone morphogenesis
namespace: biological_process
def: "The process in which the structures of a chondrocyte that will contribute to bone development are generated and organized." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0090171 ! chondrocyte morphogenesis
intersection_of: GO:0090171 ! chondrocyte morphogenesis
intersection_of: part_of GO:0060350 ! endochondral bone morphogenesis
relationship: part_of GO:0003433 ! chondrocyte development involved in endochondral bone morphogenesis
relationship: part_of GO:0060350 ! endochondral bone morphogenesis
created_by: dph
creation_date: 2009-12-22T08:42:55Z

[Term]
id: GO:0003415
name: chondrocyte hypertrophy
namespace: biological_process
def: "The growth of a chondrocyte, where growth contributes to the progression of the chondrocyte over time." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0048588 ! developmental cell growth
relationship: part_of GO:0002063 ! chondrocyte development
created_by: dph
creation_date: 2009-12-22T08:48:44Z

[Term]
id: GO:0003416
name: endochondral bone growth
namespace: biological_process
def: "The increase in size or mass of an endochondral bone that contributes to the shaping of the bone." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0098868 ! bone growth
created_by: dph
creation_date: 2009-12-22T08:52:55Z

[Term]
id: GO:0003417
name: growth plate cartilage development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones as they elongate or grow." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0060351 ! cartilage development involved in endochondral bone morphogenesis
is_a: GO:0061448 ! connective tissue development
relationship: part_of GO:0003416 ! endochondral bone growth
created_by: dph
creation_date: 2009-12-22T08:57:42Z

[Term]
id: GO:0003418
name: growth plate cartilage chondrocyte differentiation
namespace: biological_process
def: "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the growth of a bone. A chondrocyte is a polymorphic cell that forms cartilage." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003413 ! chondrocyte differentiation involved in endochondral bone morphogenesis
relationship: part_of GO:0003417 ! growth plate cartilage development
created_by: dph
creation_date: 2009-12-22T09:00:56Z

[Term]
id: GO:0003419
name: growth plate cartilage chondrocyte proliferation
namespace: biological_process
def: "The multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0008283 ! cell proliferation
relationship: part_of GO:0003417 ! growth plate cartilage development
created_by: dph
creation_date: 2009-12-22T09:02:51Z

[Term]
id: GO:0003420
name: regulation of growth plate cartilage chondrocyte proliferation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0042127 ! regulation of cell proliferation
is_a: GO:0046620 ! regulation of organ growth
is_a: GO:0061035 ! regulation of cartilage development
is_a: GO:1903010 ! regulation of bone development
is_a: GO:2000027 ! regulation of organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003419 ! growth plate cartilage chondrocyte proliferation
relationship: regulates GO:0003419 ! growth plate cartilage chondrocyte proliferation
created_by: dph
creation_date: 2009-12-22T09:07:40Z

[Term]
id: GO:0003421
name: growth plate cartilage axis specification
namespace: biological_process
def: "The establishment, maintenance and elaboration of the columnar cartilage along the axis of a long bone that contributes to bone growth." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "growth plate cartilage axis determination" RELATED [GOC:dph]
is_a: GO:0009798 ! axis specification
relationship: part_of GO:0003422 ! growth plate cartilage morphogenesis
created_by: dph
creation_date: 2009-12-22T09:16:33Z

[Term]
id: GO:0003422
name: growth plate cartilage morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of cartilage are generated and organized." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0060536 ! cartilage morphogenesis
relationship: part_of GO:0003417 ! growth plate cartilage development
created_by: dph
creation_date: 2009-12-22T09:21:30Z

[Term]
id: GO:0003423
name: growth plate cartilage chondrocyte division
namespace: biological_process
def: "The process resulting in the oriented physical partitioning and separation of a chondrocytes in the growth plate." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0051301 ! cell division
relationship: part_of GO:0003419 ! growth plate cartilage chondrocyte proliferation
created_by: dph
creation_date: 2009-12-22T09:55:51Z

[Term]
id: GO:0003424
name: establishment of cell polarity involved in growth plate cartilage chondrocyte division
namespace: biological_process
def: "The cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization that results in the directional division of a growth plate cartilage chondrocyte." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "growth plate cartilage chondrocyte polarization" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0001736 ! establishment of planar polarity
is_a: GO:0030010 ! establishment of cell polarity
intersection_of: GO:0030010 ! establishment of cell polarity
intersection_of: part_of GO:0003423 ! growth plate cartilage chondrocyte division
relationship: part_of GO:0003423 ! growth plate cartilage chondrocyte division
created_by: dph
creation_date: 2009-12-22T10:18:10Z

[Term]
id: GO:0003425
name: establishment of mitotic spindle orientation involved in growth plate cartilage chondrocyte division
namespace: biological_process
def: "A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures and contributes to oriented chondrocyte division in the growth plate." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0000132 ! establishment of mitotic spindle orientation
is_a: GO:0003426 ! cytoskeleton polarization involved in growth plate cartilage chondrocyte division
is_a: GO:0090176 ! microtubule cytoskeleton organization involved in establishment of planar polarity
intersection_of: GO:0051294 ! establishment of spindle orientation
intersection_of: part_of GO:0003423 ! growth plate cartilage chondrocyte division
relationship: part_of GO:0003423 ! growth plate cartilage chondrocyte division
created_by: dph
creation_date: 2009-12-22T10:36:36Z

[Term]
id: GO:0003426
name: cytoskeleton polarization involved in growth plate cartilage chondrocyte division
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the polarization of cytoskeletal structures in a growth plate cartilage chondrocyte. This process results in the oriented division of the cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0030952 ! establishment or maintenance of cytoskeleton polarity
intersection_of: GO:0030952 ! establishment or maintenance of cytoskeleton polarity
intersection_of: part_of GO:0003424 ! establishment of cell polarity involved in growth plate cartilage chondrocyte division
relationship: part_of GO:0003424 ! establishment of cell polarity involved in growth plate cartilage chondrocyte division
created_by: dph
creation_date: 2009-12-22T11:38:22Z

[Term]
id: GO:0003427
name: regulation of cytoskeleton polarization involved in growth plate cartilage chondrocyte division
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell that modulates the rate, frequency, or extent of the polarization of cytoskeletal structures in a growth plate cartilage chondrocyte. This process results in the oriented division of the cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "regulation of cytoskeleton polarization involved in growth plate cartilage chondrocyte division by planar cell polarity pathway" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003420 ! regulation of growth plate cartilage chondrocyte proliferation
is_a: GO:0051302 ! regulation of cell division
is_a: GO:0051493 ! regulation of cytoskeleton organization
is_a: GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway
is_a: GO:2000114 ! regulation of establishment of cell polarity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003426 ! cytoskeleton polarization involved in growth plate cartilage chondrocyte division
relationship: regulates GO:0003426 ! cytoskeleton polarization involved in growth plate cartilage chondrocyte division
created_by: dph
creation_date: 2009-12-22T11:43:29Z

[Term]
id: GO:0003428
name: chondrocyte intercalation involved in growth plate cartilage morphogenesis
namespace: biological_process
def: "The orderly movement of a chondrocyte from one site to another that contributes to the shaping of growth plate cartilage in an endochondral bone." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0016477 ! cell migration
relationship: part_of GO:0003422 ! growth plate cartilage morphogenesis
relationship: part_of GO:0060029 ! convergent extension involved in organogenesis
created_by: dph
creation_date: 2009-12-22T11:52:32Z

[Term]
id: GO:0003429
name: growth plate cartilage chondrocyte morphogenesis
namespace: biological_process
def: "The process in which the structures of a chondrocyte in the growth plate cartilage are generated and organized." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003414 ! chondrocyte morphogenesis involved in endochondral bone morphogenesis
is_a: GO:0003422 ! growth plate cartilage morphogenesis
relationship: part_of GO:0003418 ! growth plate cartilage chondrocyte differentiation
created_by: dph
creation_date: 2009-12-22T12:22:24Z

[Term]
id: GO:0003430
name: growth plate cartilage chondrocyte growth
namespace: biological_process
def: "The growth of a growth plate cartilage chondrocyte, where growth contributes to the progression of the chondrocyte over time from one condition to another." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "growth plate cartilage chondrocyte hypertrophy" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003415 ! chondrocyte hypertrophy
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0003431 ! growth plate cartilage chondrocyte development
created_by: dph
creation_date: 2009-12-22T12:29:19Z

[Term]
id: GO:0003431
name: growth plate cartilage chondrocyte development
namespace: biological_process
def: "The progression of a growth plate cartilage chondrocyte over time from after its fate commitment to the mature cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003433 ! chondrocyte development involved in endochondral bone morphogenesis
relationship: part_of GO:0003418 ! growth plate cartilage chondrocyte differentiation
created_by: dph
creation_date: 2009-12-22T12:32:49Z

[Term]
id: GO:0003432
name: cell growth involved in growth plate cartilage chondrocyte morphogenesis
namespace: biological_process
def: "The growth of a growth plate cartilage chondrocyte, where growth contributes to the shaping of the chondrocyte over time." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003430 ! growth plate cartilage chondrocyte growth
intersection_of: GO:0048588 ! developmental cell growth
intersection_of: part_of GO:0003429 ! growth plate cartilage chondrocyte morphogenesis
relationship: part_of GO:0003429 ! growth plate cartilage chondrocyte morphogenesis
created_by: dph
creation_date: 2009-12-22T12:37:48Z

[Term]
id: GO:0003433
name: chondrocyte development involved in endochondral bone morphogenesis
namespace: biological_process
def: "The progression of a chondrocyte over time from after its commitment to its mature state where the chondrocyte will contribute to the shaping of an endochondral bone." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0002063 ! chondrocyte development
intersection_of: GO:0002063 ! chondrocyte development
intersection_of: part_of GO:0060350 ! endochondral bone morphogenesis
relationship: part_of GO:0003413 ! chondrocyte differentiation involved in endochondral bone morphogenesis
relationship: part_of GO:0060350 ! endochondral bone morphogenesis
created_by: dph
creation_date: 2009-12-22T12:42:44Z

[Term]
id: GO:0003434
name: BMP signaling pathway involved in growth plate cartilage chondrocyte development
namespace: biological_process
def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the progression of a growth plate cartilage chondrocyte over time." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "BMP signalling pathway involved in growth plate cartilage chondrocyte development" EXACT [GOC:mah]
is_a: GO:0030509 ! BMP signaling pathway
intersection_of: GO:0030509 ! BMP signaling pathway
intersection_of: part_of GO:0003431 ! growth plate cartilage chondrocyte development
relationship: part_of GO:0003431 ! growth plate cartilage chondrocyte development
created_by: dph
creation_date: 2009-12-22T12:50:17Z

[Term]
id: GO:0003435
name: smoothened signaling pathway involved in growth plate cartilage chondrocyte development
namespace: biological_process
def: "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened that contributes to the progression of a growth plate cartilage chondrocyte over time." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "hedgehog signaling pathway involved in growth plate cartilage chondrocyte development" EXACT [GOC:bf, GOC:ecd]
synonym: "hh signaling pathway involved in growth plate cartilage chondrocyte development" EXACT [GOC:bf, GOC:ecd]
synonym: "smoothened signalling pathway involved in growth plate cartilage chondrocyte development" EXACT [GOC:mah]
is_a: GO:0007224 ! smoothened signaling pathway
intersection_of: GO:0007224 ! smoothened signaling pathway
intersection_of: part_of GO:0003431 ! growth plate cartilage chondrocyte development
relationship: part_of GO:0003431 ! growth plate cartilage chondrocyte development
created_by: dph
creation_date: 2009-12-22T01:02:42Z

[Term]
id: GO:0003436
name: regulation of cell adhesion involved in growth plate cartilage morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix and contributes to the shaping of the growth plate cartilage of an endochondral bone." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0030155 ! regulation of cell adhesion
intersection_of: GO:0030155 ! regulation of cell adhesion
intersection_of: part_of GO:0003422 ! growth plate cartilage morphogenesis
relationship: part_of GO:0003422 ! growth plate cartilage morphogenesis
created_by: dph
creation_date: 2009-12-22T01:28:15Z

[Term]
id: GO:0003437
name: regulation of cell communication involved in growth plate cartilage morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell communication that contributes to the shaping of the growth plate cartilage." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0010646 ! regulation of cell communication
intersection_of: GO:0010646 ! regulation of cell communication
intersection_of: part_of GO:0003422 ! growth plate cartilage morphogenesis
relationship: part_of GO:0003422 ! growth plate cartilage morphogenesis
created_by: dph
creation_date: 2009-12-22T01:34:24Z

[Term]
id: GO:0003673
name: obsolete Gene_Ontology
namespace: biological_process
def: "OBSOLETE. A controlled vocabulary that can be applied to all organisms even as knowledge of gene and protein roles in cells is accumulating and changing. GO provides three structured networks of defined terms to describe gene product attributes." [GOC:go_curators]
comment: This term was made obsolete because more specific terms were created.
synonym: "Gene_Ontology" EXACT []
is_obsolete: true

[Term]
id: GO:0003674
name: molecular_function
namespace: molecular_function
alt_id: GO:0005554
def: "Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions." [GOC:go_curators]
comment: Note that, in addition to forming the root of the molecular function ontology, this term is recommended for use for the annotation of gene products whose molecular function is unknown. Note that when this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this.
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "molecular function" EXACT []

[Term]
id: GO:0003675
name: obsolete protein
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
synonym: "protein" EXACT []
is_obsolete: true

[Term]
id: GO:0003676
name: nucleic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
subset: goslim_chembl
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding

[Term]
id: GO:0003677
name: DNA binding
namespace: molecular_function
def: "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "microtubule/chromatin interaction" RELATED []
synonym: "plasmid binding" NARROW []
is_a: GO:0003676 ! nucleic acid binding

[Term]
id: GO:0003678
name: DNA helicase activity
namespace: molecular_function
alt_id: GO:0003679
def: "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah]
subset: gosubset_prok
xref: Reactome:REACT_116013 "BRIP1 (FANCJ) helicase functions in direct unwinding of DNA, Gallus gallus"
is_a: GO:0004386 ! helicase activity
relationship: part_of GO:0032508 ! DNA duplex unwinding

[Term]
id: GO:0003680
name: AT DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with oligo(A) and oligo(T) tracts of DNA (AT DNA)." [GOC:jl, PMID:2670564]
synonym: "AT binding" EXACT []
is_a: GO:1990837 ! sequence-specific double-stranded DNA binding

[Term]
id: GO:0003681
name: bent DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with DNA in a bent conformation." [GOC:jl, PMID:12627977]
subset: gosubset_prok
is_a: GO:0043566 ! structure-specific DNA binding

[Term]
id: GO:0003682
name: chromatin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
subset: goslim_chembl
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
synonym: "lamin/chromatin binding" BROAD []
synonym: "microtubule/chromatin interaction" RELATED []
synonym: "nuclear membrane vesicle binding to chromatin" NARROW []
is_a: GO:0044877 ! macromolecular complex binding

[Term]
id: GO:0003683
name: obsolete lamin/chromatin binding
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents two functions.
synonym: "lamin/chromatin binding" EXACT []
is_obsolete: true
consider: GO:0003682
consider: GO:0005521

[Term]
id: GO:0003684
name: damaged DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with damaged DNA." [GOC:jl]
subset: gosubset_prok
synonym: "DNA repair enzyme" RELATED []
synonym: "DNA repair protein" RELATED []
xref: Reactome:REACT_100664 "Oxidative demethylation of 1-EtA damaged DNA By ABH2, Rattus norvegicus"
xref: Reactome:REACT_101048 "Oxidative demethylation of 1-MeA damaged DNA By ABH3, Bos taurus"
xref: Reactome:REACT_101116 "Oxidative demethylation of 1-EtA damaged DNA By ABH2, Xenopus tropicalis"
xref: Reactome:REACT_103019 "Oxidative demethylation of 1-EtA damaged DNA By ABH3, Rattus norvegicus"
xref: Reactome:REACT_103328 "Oxidative demethylation of 3-MeC damaged DNA By ABH2, Mus musculus"
xref: Reactome:REACT_103380 "Oxidative demethylation of 1-MeA damaged DNA By ABH3, Xenopus tropicalis"
xref: Reactome:REACT_103899 "Oxidative demethylation of 3-MeC damaged DNA By ABH3, Taeniopygia guttata"
xref: Reactome:REACT_104175 "Oxidative demethylation of 1-MeA damaged DNA By ABH2, Danio rerio"
xref: Reactome:REACT_104346 "Oxidative demethylation of 1-MeA damaged DNA By ABH2, Bos taurus"
xref: Reactome:REACT_105157 "Oxidative demethylation of 3-MeC damaged DNA By ABH2, Bos taurus"
xref: Reactome:REACT_105628 "Oxidative demethylation of 3-MeC damaged DNA By ABH3, Danio rerio"
xref: Reactome:REACT_106525 "Oxidative demethylation of 1-MeA damaged DNA By ABH3, Taeniopygia guttata"
xref: Reactome:REACT_110972 "Oxidative demethylation of 1-MeA damaged DNA By ABH3, Mus musculus"
xref: Reactome:REACT_110979 "Oxidative demethylation of 1-MeA damaged DNA By ABH2, Mus musculus"
xref: Reactome:REACT_113582 "Oxidative demethylation of 3-MeC damaged DNA By ABH2, Arabidopsis thaliana"
xref: Reactome:REACT_113713 "Oxidative demethylation of 1-EtA damaged DNA By ABH2, Arabidopsis thaliana"
xref: Reactome:REACT_113838 "Oxidative demethylation of 1-EtA damaged DNA By ABH2, Oryza sativa"
xref: Reactome:REACT_114851 "Oxidative demethylation of 3-MeC damaged DNA By ABH2, Oryza sativa"
xref: Reactome:REACT_1435 "Oxidative demethylation of 3-MeC damaged DNA By ABH3, Homo sapiens"
xref: Reactome:REACT_1696 "Oxidative demethylation of 1-MeA damaged DNA By ABH2, Homo sapiens"
xref: Reactome:REACT_1934 "Oxidative demethylation of 1-EtA damaged DNA By ABH3, Homo sapiens"
xref: Reactome:REACT_2185 "Oxidative demethylation of 3-MeC damaged DNA By ABH2, Homo sapiens"
xref: Reactome:REACT_28366 "Oxidative demethylation of 1-MeA damaged DNA By ABH2, Gallus gallus"
xref: Reactome:REACT_29673 "Oxidative demethylation of 1-MeA damaged DNA By ABH2, Mycobacterium tuberculosis"
xref: Reactome:REACT_30891 "Oxidative demethylation of 1-MeA damaged DNA By ABH3, Danio rerio"
xref: Reactome:REACT_31436 "Oxidative demethylation of 3-MeC damaged DNA By ABH2, Sus scrofa"
xref: Reactome:REACT_33416 "Oxidative demethylation of 3-MeC damaged DNA By ABH3, Mus musculus"
xref: Reactome:REACT_33600 "Oxidative demethylation of 1-MeA damaged DNA By ABH2, Canis familiaris"
xref: Reactome:REACT_33888 "Oxidative demethylation of 1-MeA damaged DNA By ABH2, Xenopus tropicalis"
xref: Reactome:REACT_462 "Oxidative demethylation of 1-MeA damaged DNA By ABH3, Homo sapiens"
xref: Reactome:REACT_52866 "Oxidative demethylation of 3-MeC damaged DNA By ABH3, Bos taurus"
xref: Reactome:REACT_77587 "Oxidative demethylation of 1-EtA damaged DNA By ABH3, Danio rerio"
xref: Reactome:REACT_783 "Oxidative demethylation of 1-EtA damaged DNA By ABH2, Homo sapiens"
xref: Reactome:REACT_79824 "Oxidative demethylation of 1-MeA damaged DNA By ABH2, Sus scrofa"
xref: Reactome:REACT_81071 "Oxidative demethylation of 3-MeC damaged DNA By ABH3, Canis familiaris"
xref: Reactome:REACT_81112 "Oxidative demethylation of 1-EtA damaged DNA By ABH2, Canis familiaris"
xref: Reactome:REACT_81735 "Oxidative demethylation of 1-EtA damaged DNA By ABH2, Sus scrofa"
xref: Reactome:REACT_82167 "Oxidative demethylation of 1-EtA damaged DNA By ABH2, Gallus gallus"
xref: Reactome:REACT_83944 "Oxidative demethylation of 1-EtA damaged DNA By ABH3, Bos taurus"
xref: Reactome:REACT_84763 "Oxidative demethylation of 3-MeC damaged DNA By ABH2, Gallus gallus"
xref: Reactome:REACT_84781 "Oxidative demethylation of 3-MeC damaged DNA By ABH2, Rattus norvegicus"
xref: Reactome:REACT_84951 "Oxidative demethylation of 3-MeC damaged DNA By ABH3, Xenopus tropicalis"
xref: Reactome:REACT_85779 "Oxidative demethylation of 1-MeA damaged DNA By ABH2, Oryza sativa"
xref: Reactome:REACT_86067 "Oxidative demethylation of 1-EtA damaged DNA By ABH2, Taeniopygia guttata"
xref: Reactome:REACT_87009 "Oxidative demethylation of 1-MeA damaged DNA By ABH2, Rattus norvegicus"
xref: Reactome:REACT_88774 "Oxidative demethylation of 3-MeC damaged DNA By ABH2, Canis familiaris"
xref: Reactome:REACT_88901 "Oxidative demethylation of 1-EtA damaged DNA By ABH3, Canis familiaris"
xref: Reactome:REACT_89666 "Oxidative demethylation of 3-MeC damaged DNA By ABH2, Xenopus tropicalis"
xref: Reactome:REACT_89685 "Oxidative demethylation of 3-MeC damaged DNA By ABH2, Mycobacterium tuberculosis"
xref: Reactome:REACT_89917 "Oxidative demethylation of 3-MeC damaged DNA By ABH2, Danio rerio"
xref: Reactome:REACT_90545 "Oxidative demethylation of 1-MeA damaged DNA By ABH3, Canis familiaris"
xref: Reactome:REACT_91221 "Oxidative demethylation of 1-EtA damaged DNA By ABH2, Bos taurus"
xref: Reactome:REACT_91729 "Oxidative demethylation of 3-MeC damaged DNA By ABH3, Gallus gallus"
xref: Reactome:REACT_91817 "Oxidative demethylation of 1-EtA damaged DNA By ABH3, Taeniopygia guttata"
xref: Reactome:REACT_92004 "Oxidative demethylation of 1-EtA damaged DNA By ABH2, Danio rerio"
xref: Reactome:REACT_92429 "Oxidative demethylation of 1-EtA damaged DNA By ABH2, Mus musculus"
xref: Reactome:REACT_93699 "Oxidative demethylation of 1-MeA damaged DNA By ABH2, Taeniopygia guttata"
xref: Reactome:REACT_93716 "Oxidative demethylation of 1-EtA damaged DNA By ABH3, Gallus gallus"
xref: Reactome:REACT_93739 "Oxidative demethylation of 1-EtA damaged DNA By ABH2, Mycobacterium tuberculosis"
xref: Reactome:REACT_94142 "Oxidative demethylation of 1-EtA damaged DNA By ABH3, Xenopus tropicalis"
xref: Reactome:REACT_94682 "Oxidative demethylation of 1-EtA damaged DNA By ABH3, Mus musculus"
xref: Reactome:REACT_95130 "Oxidative demethylation of 1-MeA damaged DNA By ABH2, Arabidopsis thaliana"
xref: Reactome:REACT_97138 "Oxidative demethylation of 1-MeA damaged DNA By ABH3, Rattus norvegicus"
xref: Reactome:REACT_97358 "Oxidative demethylation of 3-MeC damaged DNA By ABH3, Rattus norvegicus"
xref: Reactome:REACT_98435 "Oxidative demethylation of 3-MeC damaged DNA By ABH2, Taeniopygia guttata"
xref: Reactome:REACT_98953 "Oxidative demethylation of 1-MeA damaged DNA By ABH3, Gallus gallus"
is_a: GO:0003677 ! DNA binding

[Term]
id: GO:0003685
name: obsolete DNA repair protein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh]
comment: This term was made obsolete because it includes a process term.
synonym: "DNA repair protein" EXACT []
is_obsolete: true
consider: GO:0003684

[Term]
id: GO:0003686
name: obsolete DNA repair enzyme
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh]
comment: This term was made obsolete because it includes a process term.
synonym: "DNA repair enzyme" EXACT []
is_obsolete: true
consider: GO:0003684

[Term]
id: GO:0003687
name: obsolete DNA replication factor
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it does not represent a true molecular function.
synonym: "DNA replication factor" EXACT []
is_obsolete: true
consider: GO:0006260

[Term]
id: GO:0003688
name: DNA replication origin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally." [GOC:curators]
subset: gosubset_prok
synonym: "ARS binding" NARROW []
is_a: GO:1990837 ! sequence-specific double-stranded DNA binding

[Term]
id: GO:0003689
name: DNA clamp loader activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex." [GOC:mah, GOC:vw, PMID:16082778]
subset: gosubset_prok
synonym: "DNA clamp loading ATPase activity" EXACT []
synonym: "PCNA loading activity" NARROW []
synonym: "PCNA loading complex activity" NARROW []
xref: Reactome:REACT_106382 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Drosophila melanogaster"
xref: Reactome:REACT_107423 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Caenorhabditis elegans"
xref: Reactome:REACT_113703 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Gallus gallus"
xref: Reactome:REACT_29764 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Taeniopygia guttata"
xref: Reactome:REACT_33572 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Dictyostelium discoideum"
xref: Reactome:REACT_50018 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Rattus norvegicus"
xref: Reactome:REACT_6729 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Homo sapiens"
xref: Reactome:REACT_79188 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Canis familiaris"
xref: Reactome:REACT_88384 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Schizosaccharomyces pombe"
xref: Reactome:REACT_90809 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Danio rerio"
xref: Reactome:REACT_92527 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Mus musculus"
xref: Reactome:REACT_92644 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Xenopus tropicalis"
xref: Reactome:REACT_96998 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Bos taurus"
is_a: GO:0003677 ! DNA binding
is_a: GO:0033170 ! protein-DNA loading ATPase activity

[Term]
id: GO:0003690
name: double-stranded DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with double-stranded DNA." [GOC:elh, GOC:vw]
subset: gosubset_prok
synonym: "dsDNA binding" EXACT [GOC:elh]
is_a: GO:0003677 ! DNA binding
disjoint_from: GO:0003697 ! single-stranded DNA binding

[Term]
id: GO:0003691
name: double-stranded telomeric DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with double-stranded telomere-associated DNA." [GOC:jl, ISBN:0321000382]
is_a: GO:0003690 ! double-stranded DNA binding
is_a: GO:0042162 ! telomeric DNA binding

[Term]
id: GO:0003692
name: left-handed Z-DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with DNA in the Z form, i.e. a left-handed helix in which the phosphate backbone zigzags." [ISBN:0716720094]
is_a: GO:0043566 ! structure-specific DNA binding

[Term]
id: GO:0003693
name: P-element binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any P-element, a class of Drosophila transposon responsible for hybrid dysgenesis." [GOC:jl, PMID:9440262]
is_a: GO:1990837 ! sequence-specific double-stranded DNA binding

[Term]
id: GO:0003694
name: obsolete plasmid binding
namespace: molecular_function
def: "OBSOLETE. Interacting selectively with a plasmid, an extrachromosomal genetic element usually characterized as a covalently continuous double stranded DNA molecule found in bacteria and some other microorganisms." [ISBN:0198506732]
comment: This term was made obsolete because it refers to component information.
synonym: "plasmid binding" EXACT []
synonym: "plasmid-associated protein" RELATED []
is_obsolete: true
consider: GO:0003677
consider: GO:0005727

[Term]
id: GO:0003695
name: random coil DNA binding
namespace: molecular_function
alt_id: GO:0016017
def: "Interacting selectively and non-covalently with DNA in a random coil configuration." [GOC:mah]
synonym: "random coil binding" EXACT []
is_a: GO:0043566 ! structure-specific DNA binding

[Term]
id: GO:0003696
name: satellite DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with satellite DNA, the many tandem repeats (identical or related) of a short basic repeating unit; many have a base composition or other property different from the genome average that allows them to be separated from the bulk (main band) genomic DNA." [GOC:jl, SO:0000005]
is_a: GO:1990837 ! sequence-specific double-stranded DNA binding

[Term]
id: GO:0003697
name: single-stranded DNA binding
namespace: molecular_function
alt_id: GO:0003698
alt_id: GO:0003699
def: "Interacting selectively and non-covalently with single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]
comment: Note that this term is restricted to those cases where the binding is to a single-stranded DNA molecule, not to one of the stands of double-stranded DNA.
subset: gosubset_prok
synonym: "ssDNA binding" EXACT [GOC:mah]
is_a: GO:0003677 ! DNA binding

[Term]
id: GO:0003700
name: transcription factor activity, sequence-specific DNA binding
namespace: molecular_function
alt_id: GO:0000130
def: "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
subset: goslim_plant
subset: gosubset_prok
synonym: "sequence-specific DNA binding transcription factor activity" EXACT []
synonym: "transcription factor activity" BROAD []
is_a: GO:0001071 ! nucleic acid binding transcription factor activity
relationship: has_part GO:0000976 ! transcription regulatory region sequence-specific DNA binding
relationship: part_of GO:0006355 ! regulation of transcription, DNA-templated

[Term]
id: GO:0003701
name: obsolete RNA polymerase I transcription factor activity
namespace: molecular_function
def: "OBSOLETE. Functions to initiate or regulate RNA polymerase I transcription." [GOC:jl]
comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
synonym: "RNA polymerase I transcription factor activity" EXACT []
is_obsolete: true
consider: GO:0001082
consider: GO:0001167
consider: GO:0006360

[Term]
id: GO:0003702
name: obsolete RNA polymerase II transcription factor activity
namespace: molecular_function
def: "OBSOLETE. Functions to initiate or regulate RNA polymerase II transcription." [GOC:jl]
comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
synonym: "RNA polymerase II transcription factor activity" EXACT []
is_obsolete: true
consider: GO:0000981
consider: GO:0000991
consider: GO:0001076
consider: GO:0006366

[Term]
id: GO:0003704
name: obsolete specific RNA polymerase II transcription factor activity
namespace: molecular_function
def: "OBSOLETE. Functions to enable the transcription of specific, or specific sets, of genes by RNA polymerase II." [GOC:ma]
comment: This term was obsoleted because "general/nonspecific/basal" transcription vs "specific" transcription were determined not to be separable, distinct process. Thus, terms trying to distinguish "general/nonspecific/basal" transcription from "specific" transcription were removed from both the Molecular Function and the Biological Process ontologies. In addition, this Molecular Function term was defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
synonym: "specific RNA polymerase II transcription factor activity" EXACT []
is_obsolete: true
consider: GO:0000981
consider: GO:0000991
consider: GO:0001076
consider: GO:0006366

[Term]
id: GO:0003705
name: transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II." [GOC:jl, GOC:txnOH]
synonym: "RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity" EXACT []
synonym: "sequence-specific distal enhancer binding RNA polymerase II transcription factor activity" EXACT []
is_a: GO:0000981 ! RNA polymerase II transcription factor activity, sequence-specific DNA binding
relationship: has_part GO:0000980 ! RNA polymerase II distal enhancer sequence-specific DNA binding

[Term]
id: GO:0003706
name: obsolete ligand-regulated transcription factor activity
namespace: molecular_function
def: "OBSOLETE. Functions to enable the transcription of specific, or specific sets, of genes by RNA polymerase II in response to a ligand." [GOC:curators]
comment: This term was made obsolete because it does not convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism.
synonym: "ligand-regulated transcription factor activity" EXACT []
is_obsolete: true
consider: GO:0004879
consider: GO:0038049

[Term]
id: GO:0003707
name: steroid hormone receptor activity
namespace: molecular_function
def: "Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019]
comment: Some steroid hormone receptors reside in the plasma membrane and signal through second messengers or other intracellular signal transduction pathways. For steroid hormone receptors that act in the nucleus to regulate transcription, consider also annotating to the terms: ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity ; GO:0038049' or ligand-activated RNA polymerase II transcription factor binding transcription factor activity ; GO:0038049'.
is_a: GO:0038023 ! signaling receptor activity
relationship: part_of GO:0043401 ! steroid hormone mediated signaling pathway

[Term]
id: GO:0003708
name: retinoic acid receptor activity
namespace: molecular_function
def: "Combining with retinoic acid and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. Retinoic acid is one of the forms of vitamin A." [GOC:signaling, PMID:1328967]
synonym: "vitamin A receptor activity" BROAD []
is_a: GO:0004879 ! RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
is_a: GO:0038023 ! signaling receptor activity
relationship: has_part GO:0001972 ! retinoic acid binding
relationship: part_of GO:0048384 ! retinoic acid receptor signaling pathway

[Term]
id: GO:0003709
name: obsolete RNA polymerase III transcription factor activity
namespace: molecular_function
def: "OBSOLETE. Functions to initiate or regulate RNA polymerase III transcription." [GOC:jl]
comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
synonym: "RNA polymerase III transcription factor activity" EXACT []
is_obsolete: true
consider: GO:0000995
consider: GO:0001007
consider: GO:0001034
consider: GO:0006383

[Term]
id: GO:0003711
name: obsolete transcription elongation regulator activity
namespace: molecular_function
def: "OBSOLETE. Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation." [GOC:mah]
comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
subset: gosubset_prok
synonym: "transcription elongation factor activity" EXACT []
synonym: "transcription elongation regulator activity" EXACT []
synonym: "transcriptional elongation regulator activity" EXACT []
is_obsolete: true
consider: GO:0032784

[Term]
id: GO:0003712
name: transcription cofactor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with a regulatory transcription factor and also with the basal transcription machinery in order to modulate transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
subset: gosubset_prok
synonym: "transcription cofactor activity" EXACT []
synonym: "transcriptional co-regulator" EXACT []
synonym: "transcriptional cofactor activity" EXACT []
is_a: GO:0000989 ! transcription factor activity, transcription factor binding
relationship: has_part GO:0001098 ! basal transcription machinery binding

[Term]
id: GO:0003713
name: transcription coactivator activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
subset: gosubset_prok
synonym: "transcription co-activator activity" EXACT []
synonym: "transcription coactivator activity" EXACT []
is_a: GO:0003712 ! transcription cofactor activity
relationship: has_part GO:0033613 ! activating transcription factor binding

[Term]
id: GO:0003714
name: transcription corepressor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with a repressing transcription factor and also with the basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
synonym: "transcription co-repressor activity" EXACT []
synonym: "transcription corepressor activity" EXACT []
is_a: GO:0003712 ! transcription cofactor activity
relationship: has_part GO:0070491 ! repressing transcription factor binding
relationship: part_of GO:1903507 ! negative regulation of nucleic acid-templated transcription

[Term]
id: GO:0003715
name: obsolete transcription termination factor activity
namespace: molecular_function
def: "OBSOLETE. Any activity that brings about termination of transcription." [GOC:mah]
comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
subset: gosubset_prok
synonym: "transcription termination factor activity" EXACT []
synonym: "transcriptional termination factor activity" EXACT []
is_obsolete: true
consider: GO:0006353

[Term]
id: GO:0003716
name: obsolete RNA polymerase I transcription termination factor activity
namespace: molecular_function
def: "OBSOLETE. Any activity that brings about termination of transcription by RNA polymerase I." [GOC:mah]
comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
synonym: "Pol I transcription termination factor activity" EXACT []
synonym: "RNA polymerase I transcription termination factor activity" EXACT []
is_obsolete: true
consider: GO:0006363

[Term]
id: GO:0003717
name: obsolete RNA polymerase II transcription termination factor activity
namespace: molecular_function
def: "OBSOLETE. Any activity that brings about termination of transcription by RNA polymerase II." [GOC:mah]
comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
synonym: "Pol II transcription termination factor activity" EXACT []
synonym: "RNA polymerase II transcription termination factor activity" EXACT []
is_obsolete: true
consider: GO:0006369

[Term]
id: GO:0003718
name: obsolete RNA polymerase III transcription termination factor activity
namespace: molecular_function
def: "OBSOLETE. Any activity that brings about termination of transcription by RNA polymerase III." [GOC:mah]
comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
synonym: "Pol III transcription termination factor activity" EXACT []
synonym: "RNA polymerase III transcription termination factor activity" EXACT []
is_obsolete: true
consider: GO:0006386

[Term]
id: GO:0003719
name: obsolete transcription factor binding, cytoplasmic sequestering
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because sequestering is a process rather than a function.
synonym: "transcription factor binding, cytoplasmic sequestering" EXACT []
is_obsolete: true
replaced_by: GO:0042994

[Term]
id: GO:0003720
name: telomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence." [GOC:krc]
xref: EC:2.7.7.-
xref: Reactome:REACT_104705 "Elongation of Extended Telomeric Chromosome End, Saccharomyces cerevisiae"
xref: Reactome:REACT_106476 "Elongation Of The Telomeric Chromosome End, Bos taurus"
xref: Reactome:REACT_108407 "Elongation of Extended Telomeric Chromosome End, Oryza sativa"
xref: Reactome:REACT_109443 "Elongation Of The Telomeric Chromosome End, Danio rerio"
xref: Reactome:REACT_113385 "Elongation Of The Telomeric Chromosome End, Xenopus tropicalis"
xref: Reactome:REACT_114466 "Elongation of Extended Telomeric Chromosome End, Xenopus tropicalis"
xref: Reactome:REACT_115824 "Elongation and translocation of the extended telomeric chromosome end, Gallus gallus"
xref: Reactome:REACT_116122 "Elongation and translocation of the telomeric chromosome end, Gallus gallus"
xref: Reactome:REACT_28249 "Elongation of Extended Telomeric Chromosome End, Gallus gallus"
xref: Reactome:REACT_30494 "Elongation Of The Telomeric Chromosome End, Sus scrofa"
xref: Reactome:REACT_30995 "Elongation Of The Telomeric Chromosome End, Canis familiaris"
xref: Reactome:REACT_31549 "Elongation Of The Telomeric Chromosome End, Saccharomyces cerevisiae"
xref: Reactome:REACT_33436 "Elongation of Extended Telomeric Chromosome End, Danio rerio"
xref: Reactome:REACT_77280 "Elongation of Extended Telomeric Chromosome End, Arabidopsis thaliana"
xref: Reactome:REACT_7985 "Elongation of Extended Telomeric Chromosome End, Homo sapiens"
xref: Reactome:REACT_8019 "Elongation Of The Telomeric Chromosome End, Homo sapiens"
xref: Reactome:REACT_80834 "Elongation Of The Telomeric Chromosome End, Mus musculus"
xref: Reactome:REACT_81691 "Elongation of Extended Telomeric Chromosome End, Canis familiaris"
xref: Reactome:REACT_83982 "Elongation Of The Telomeric Chromosome End, Oryza sativa"
xref: Reactome:REACT_85286 "Elongation of Extended Telomeric Chromosome End, Bos taurus"
xref: Reactome:REACT_86666 "Elongation of Extended Telomeric Chromosome End, Sus scrofa"
xref: Reactome:REACT_90823 "Elongation of Extended Telomeric Chromosome End, Mus musculus"
xref: Reactome:REACT_93232 "Elongation Of The Telomeric Chromosome End, Schizosaccharomyces pombe"
xref: Reactome:REACT_94534 "Elongation Of The Telomeric Chromosome End, Taeniopygia guttata"
xref: Reactome:REACT_94768 "Elongation of Extended Telomeric Chromosome End, Schizosaccharomyces pombe"
xref: Reactome:REACT_95176 "Elongation Of The Telomeric Chromosome End, Gallus gallus"
xref: Reactome:REACT_96912 "Elongation of Extended Telomeric Chromosome End, Taeniopygia guttata"
xref: Reactome:REACT_97770 "Elongation Of The Telomeric Chromosome End, Arabidopsis thaliana"
is_a: GO:0003964 ! RNA-directed DNA polymerase activity

[Term]
id: GO:0003721
name: telomerase RNA reverse transcriptase activity
namespace: molecular_function
def: "Catalysis of the extension of the 3' end of a DNA strand by one deoxynucleotide at a time. Cannot initiate a chain de novo; uses the RNA subunit of the telomerase enzyme complex as its template." [EC:2.7.7.49, PMID:11812242]
synonym: "telomerase, catalyst" EXACT []
is_a: GO:0003964 ! RNA-directed DNA polymerase activity
relationship: part_of GO:0003720 ! telomerase activity

[Term]
id: GO:0003723
name: RNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
xref: Reactome:REACT_101703 "Exportin-5 recognizes 3' overhang of pre-miRNA, Xenopus tropicalis"
xref: Reactome:REACT_103323 "Exportin-5 recognizes 3' overhang of pre-miRNA, Dictyostelium discoideum"
xref: Reactome:REACT_106430 "Exportin-5 recognizes 3' overhang of pre-miRNA, Mus musculus"
xref: Reactome:REACT_107757 "Exportin-5 recognizes 3' overhang of pre-miRNA, Drosophila melanogaster"
xref: Reactome:REACT_108232 "Exportin-5 recognizes 3' overhang of pre-miRNA, Oryza sativa"
xref: Reactome:REACT_108368 "Exportin-5 recognizes 3' overhang of pre-miRNA, Saccharomyces cerevisiae"
xref: Reactome:REACT_109723 "Exportin-5 recognizes 3' overhang of pre-miRNA, Arabidopsis thaliana"
xref: Reactome:REACT_12458 "Exportin-5 recognizes 3' overhang of pre-miRNA, Homo sapiens"
xref: Reactome:REACT_29965 "Exportin-5 recognizes 3' overhang of pre-miRNA, Canis familiaris"
xref: Reactome:REACT_77167 "Exportin-5 recognizes 3' overhang of pre-miRNA, Gallus gallus"
xref: Reactome:REACT_78197 "Exportin-5 recognizes 3' overhang of pre-miRNA, Sus scrofa"
xref: Reactome:REACT_87164 "Exportin-5 recognizes 3' overhang of pre-miRNA, Schizosaccharomyces pombe"
xref: Reactome:REACT_89329 "Exportin-5 recognizes 3' overhang of pre-miRNA, Rattus norvegicus"
xref: Reactome:REACT_90531 "Exportin-5 recognizes 3' overhang of pre-miRNA, Danio rerio"
xref: Reactome:REACT_98683 "Exportin-5 recognizes 3' overhang of pre-miRNA, Taeniopygia guttata"
is_a: GO:0003676 ! nucleic acid binding

[Term]
id: GO:0003724
name: RNA helicase activity
namespace: molecular_function
def: "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a RNA helix." [GOC:jl, GOC:mah]
subset: gosubset_prok
xref: EC:2.7.7.-
xref: Reactome:REACT_110845 "Cap-bound mRNA is activated by helicases, Mus musculus"
xref: Reactome:REACT_112817 "Cap-bound mRNA is activated by helicases, Schizosaccharomyces pombe"
xref: Reactome:REACT_1521 "Cap-bound mRNA is activated by helicases, Homo sapiens"
xref: Reactome:REACT_31034 "Cap-bound mRNA is activated by helicases, Danio rerio"
xref: Reactome:REACT_84574 "Cap-bound mRNA is activated by helicases, Canis familiaris"
xref: Reactome:REACT_85111 "Cap-bound mRNA is activated by helicases, Drosophila melanogaster"
xref: Reactome:REACT_98745 "Cap-bound mRNA is activated by helicases, Xenopus tropicalis"
is_a: GO:0004386 ! helicase activity

[Term]
id: GO:0003725
name: double-stranded RNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with double-stranded RNA." [GOC:jl]
subset: gosubset_prok
synonym: "dsRNA binding" EXACT [GOC:ecd]
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0003726
name: double-stranded RNA adenosine deaminase activity
namespace: molecular_function
alt_id: GO:0003971
def: "Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a double-stranded RNA molecule." [GOC:mah]
subset: gosubset_prok
synonym: "double-stranded RNA specific editase activity" RELATED []
xref: Reactome:REACT_100080 "Deamination at C6 position of adenosine in Editosome (ADAR2), Taeniopygia guttata"
xref: Reactome:REACT_104541 "Deamination at C6 position of adenosine in Editosome (ADAR1), Sus scrofa"
xref: Reactome:REACT_110356 "Deamination at C6 position of adenosine in Editosome (ADAR1), Xenopus tropicalis"
xref: Reactome:REACT_1105 "Deamination at C6 position of adenosine in Editosome (ADAR1), Homo sapiens"
xref: Reactome:REACT_112019 "Deamination at C6 position of adenosine in Editosome (ADAR1), Oryza sativa"
xref: Reactome:REACT_112024 "Deamination at C6 position of adenosine in Editosome (ADAR1), Saccharomyces cerevisiae"
xref: Reactome:REACT_113770 "Deamination at C6 position of adenosine in Editosome (ADAR1), Caenorhabditis elegans"
xref: Reactome:REACT_114900 "Deamination at C6 position of adenosine in Editosome (ADAR1), Arabidopsis thaliana"
xref: Reactome:REACT_115470 "Deamination at C6 position of adenosine in Editosome (ADAR1), Schizosaccharomyces pombe"
xref: Reactome:REACT_29892 "Deamination at C6 position of adenosine in Editosome (ADAR2), Canis familiaris"
xref: Reactome:REACT_31966 "Deamination at C6 position of adenosine in Editosome (ADAR1), Canis familiaris"
xref: Reactome:REACT_32015 "Deamination at C6 position of adenosine in Editosome (ADAR2), Xenopus tropicalis"
xref: Reactome:REACT_365 "Deamination at C6 position of adenosine in Editosome (ADAR2), Homo sapiens"
xref: Reactome:REACT_79183 "Deamination at C6 position of adenosine in Editosome (ADAR2), Mus musculus"
xref: Reactome:REACT_79641 "Deamination at C6 position of adenosine in Editosome (ADAR1), Taeniopygia guttata"
xref: Reactome:REACT_80597 "Deamination at C6 position of adenosine in Editosome (ADAR2), Gallus gallus"
xref: Reactome:REACT_80662 "Deamination at C6 position of adenosine in Editosome (ADAR2), Bos taurus"
xref: Reactome:REACT_86066 "Deamination at C6 position of adenosine in Editosome (ADAR2), Sus scrofa"
xref: Reactome:REACT_86370 "Deamination at C6 position of adenosine in Editosome (ADAR1), Gallus gallus"
xref: Reactome:REACT_86554 "Deamination at C6 position of adenosine in Editosome (ADAR1), Rattus norvegicus"
xref: Reactome:REACT_87527 "Deamination at C6 position of adenosine in Editosome (ADAR1), Mus musculus"
xref: Reactome:REACT_90605 "Deamination at C6 position of adenosine in Editosome (ADAR2), Rattus norvegicus"
xref: Reactome:REACT_90645 "Deamination at C6 position of adenosine in Editosome (ADAR2), Danio rerio"
xref: Reactome:REACT_92526 "Deamination at C6 position of adenosine in Editosome (ADAR2), Drosophila melanogaster"
xref: Reactome:REACT_99543 "Deamination at C6 position of adenosine in Editosome (ADAR1), Bos taurus"
xref: Reactome:REACT_99769 "Deamination at C6 position of adenosine in Editosome (ADAR1), Danio rerio"
is_a: GO:0004000 ! adenosine deaminase activity

[Term]
id: GO:0003727
name: single-stranded RNA binding
namespace: molecular_function
alt_id: GO:0003728
def: "Interacting selectively and non-covalently with single-stranded RNA." [GOC:jl]
synonym: "ssRNA binding" EXACT [GOC:mah]
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0003729
name: mRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_yeast
subset: gosubset_prok
is_a: GO:0044822 ! poly(A) RNA binding

[Term]
id: GO:0003730
name: mRNA 3'-UTR binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule." [GOC:mah]
synonym: "mRNA 3' UTR binding" EXACT []
is_a: GO:0003729 ! mRNA binding

[Term]
id: GO:0003731
name: obsolete mRNA cap binding
namespace: molecular_function
def: "OBSOLETE. Interacting selectively with the 7-methylguanosine cap at the 5' end of a nascent messenger RNA transcript." [GOC:mah]
comment: This term was made obsolete because the functional distinction for cap binding is the structure of the cap, not the type of RNA it is attached to.
synonym: "mRNA cap binding" EXACT []
is_obsolete: true
consider: GO:0000339

[Term]
id: GO:0003732
name: obsolete snRNA cap binding
namespace: molecular_function
def: "OBSOLETE. Interacting selectively with the cap structure at the 5' end of a small nuclear RNA molecule." [GOC:mah]
comment: This term was made obsolete because the functional distinction for cap binding is the structure of the cap, not the type of RNA it is attached to.
synonym: "snRNA cap binding" EXACT []
is_obsolete: true
consider: GO:0000339

[Term]
id: GO:0003733
name: obsolete ribonucleoprotein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it describes a cellular component rather than a molecular function.
synonym: "ribonucleoprotein" EXACT []
is_obsolete: true
replaced_by: GO:0030529

[Term]
id: GO:0003734
name: obsolete small nuclear ribonucleoprotein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it describes a cellular component rather than a molecular function.
synonym: "small nuclear ribonucleoprotein" EXACT []
synonym: "snRNP" EXACT []
is_obsolete: true
replaced_by: GO:0030532

[Term]
id: GO:0003735
name: structural constituent of ribosome
namespace: molecular_function
alt_id: GO:0003736
alt_id: GO:0003737
alt_id: GO:0003738
alt_id: GO:0003739
alt_id: GO:0003740
alt_id: GO:0003741
alt_id: GO:0003742
def: "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
comment: Note that this term may be used to annotate ribosomal RNAs as well as ribosomal proteins.
subset: goslim_chembl
subset: goslim_generic
subset: goslim_yeast
subset: gosubset_prok
synonym: "ribosomal protein" BROAD []
synonym: "ribosomal RNA" RELATED []
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0003743
name: translation initiation factor activity
namespace: molecular_function
alt_id: GO:0003744
alt_id: GO:0003745
def: "Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]
subset: gosubset_prok
xref: Reactome:REACT_102411 "eIF2 activation, Arabidopsis thaliana"
xref: Reactome:REACT_102747 "Ribosomal scanning, Plasmodium falciparum"
xref: Reactome:REACT_104592 "Ribosomal scanning, Xenopus tropicalis"
xref: Reactome:REACT_104947 "Start codon recognition, Arabidopsis thaliana"
xref: Reactome:REACT_105336 "Ribosomal scanning, Danio rerio"
xref: Reactome:REACT_105545 "eIF2 activation, Schizosaccharomyces pombe"
xref: Reactome:REACT_105772 "Ribosomal scanning, Caenorhabditis elegans"
xref: Reactome:REACT_106049 "Ribosomal scanning, Schizosaccharomyces pombe"
xref: Reactome:REACT_107324 "eIF2 activation, Taeniopygia guttata"
xref: Reactome:REACT_108980 "Ribosomal scanning, Canis familiaris"
xref: Reactome:REACT_112013 "Start codon recognition, Gallus gallus"
xref: Reactome:REACT_114676 "Ribosomal scanning, Gallus gallus"
xref: Reactome:REACT_115071 "Ribosomal scanning, Rattus norvegicus"
xref: Reactome:REACT_115079 "Start codon recognition, Rattus norvegicus"
xref: Reactome:REACT_115451 "Start codon recognition, Bos taurus"
xref: Reactome:REACT_1401 "eIF2 activation, Homo sapiens"
xref: Reactome:REACT_1516 "Ribosomal scanning, Homo sapiens"
xref: Reactome:REACT_29285 "eIF2 activation, Danio rerio"
xref: Reactome:REACT_31248 "Ribosomal scanning, Drosophila melanogaster"
xref: Reactome:REACT_31637 "Start codon recognition, Saccharomyces cerevisiae"
xref: Reactome:REACT_32686 "eIF2 activation, Oryza sativa"
xref: Reactome:REACT_33398 "Start codon recognition, Oryza sativa"
xref: Reactome:REACT_33544 "Start codon recognition, Xenopus tropicalis"
xref: Reactome:REACT_57036 "Start codon recognition, Plasmodium falciparum"
xref: Reactome:REACT_60464 "eIF2 activation, Caenorhabditis elegans"
xref: Reactome:REACT_656 "Start codon recognition, Homo sapiens"
xref: Reactome:REACT_78159 "Start codon recognition, Caenorhabditis elegans"
xref: Reactome:REACT_78773 "eIF2 activation, Plasmodium falciparum"
xref: Reactome:REACT_79007 "Start codon recognition, Danio rerio"
xref: Reactome:REACT_81171 "Start codon recognition, Mus musculus"
xref: Reactome:REACT_82224 "eIF2 activation, Gallus gallus"
xref: Reactome:REACT_83059 "eIF2 activation, Bos taurus"
xref: Reactome:REACT_83547 "eIF2 activation, Rattus norvegicus"
xref: Reactome:REACT_83592 "eIF2 activation, Saccharomyces cerevisiae"
xref: Reactome:REACT_88632 "eIF2 activation, Mus musculus"
xref: Reactome:REACT_88913 "Ribosomal scanning, Bos taurus"
xref: Reactome:REACT_88955 "eIF2 activation, Xenopus tropicalis"
xref: Reactome:REACT_91084 "Ribosomal scanning, Arabidopsis thaliana"
xref: Reactome:REACT_91415 "Start codon recognition, Dictyostelium discoideum"
xref: Reactome:REACT_91967 "Ribosomal scanning, Dictyostelium discoideum"
xref: Reactome:REACT_91979 "Ribosomal scanning, Taeniopygia guttata"
xref: Reactome:REACT_93372 "Start codon recognition, Schizosaccharomyces pombe"
xref: Reactome:REACT_93678 "eIF2 activation, Canis familiaris"
xref: Reactome:REACT_95840 "Ribosomal scanning, Saccharomyces cerevisiae"
xref: Reactome:REACT_96533 "Ribosomal scanning, Oryza sativa"
xref: Reactome:REACT_96726 "eIF2 activation, Dictyostelium discoideum"
xref: Reactome:REACT_99607 "Ribosomal scanning, Mus musculus"
is_a: GO:0008135 ! translation factor activity, RNA binding
relationship: part_of GO:0006413 ! translational initiation

[Term]
id: GO:0003746
name: translation elongation factor activity
namespace: molecular_function
alt_id: GO:0008182
alt_id: GO:0008183
def: "Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732]
subset: gosubset_prok
xref: Reactome:REACT_9514 "Viral Protein Synthesis, Homo sapiens"
xref: Reactome:REACT_9524 "Synthesis of PB1-F2, Homo sapiens"
is_a: GO:0008135 ! translation factor activity, RNA binding
relationship: part_of GO:0006414 ! translational elongation

[Term]
id: GO:0003747
name: translation release factor activity
namespace: molecular_function
alt_id: GO:0003748
alt_id: GO:0003749
def: "Involved in catalyzing the release of a nascent polypeptide chain from a ribosome." [ISBN:0198547684]
subset: gosubset_prok
is_a: GO:0008079 ! translation termination factor activity

[Term]
id: GO:0003750
name: obsolete cell cycle regulator
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:krc]
comment: This term was made obsolete because it does not represent a single molecular function.
synonym: "cell cycle regulator" EXACT []
is_obsolete: true
replaced_by: GO:0051726

[Term]
id: GO:0003754
name: obsolete chaperone activity
namespace: molecular_function
alt_id: GO:0003757
alt_id: GO:0003758
alt_id: GO:0003760
alt_id: GO:0003761
def: "OBSOLETE. Assists in the correct non-covalent assembly of polypeptide-containing structures in vivo, but is not a component of these assembled structures when they are performing their normal biological function." [ISBN:0198547684]
comment: This term was made obsolete because, as defined, it represents a class of gene products rather than a molecular function. The term string is also ambiguous, having connotations of involvement in transport processes.
synonym: "chaperone activity" EXACT []
is_obsolete: true
consider: GO:0006457
consider: GO:0044183
consider: GO:0051082

[Term]
id: GO:0003755
name: peptidyl-prolyl cis-trans isomerase activity
namespace: molecular_function
alt_id: GO:0004752
alt_id: GO:0042028
def: "Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]
subset: gosubset_prok
synonym: "cis-trans proline isomerase activity" EXACT []
synonym: "cyclophilin activity" RELATED [EC:5.2.1.8]
synonym: "cyclophilin-type peptidyl-prolyl cis-trans isomerase activity" NARROW []
synonym: "FK506-sensitive peptidyl-prolyl cis-trans isomerase" NARROW []
synonym: "immunophilin" RELATED []
synonym: "juglone-sensitive cis-trans proline isomerase activity" NARROW [GOC:mah]
synonym: "juglone-sensitive peptidyl-prolyl cis-trans isomerase activity" NARROW [GOC:mah]
synonym: "parvulin" RELATED []
synonym: "peptide bond isomerase activity" EXACT [EC:5.2.1.8]
synonym: "peptidyl-prolyl isomerase B reaction" RELATED []
synonym: "peptidylproline cis-trans-isomerase activity" EXACT [EC:5.2.1.8]
synonym: "peptidylprolyl cis-trans isomerase activity" EXACT [EC:5.2.1.8]
synonym: "peptidylprolyl isomerase activity" EXACT [EC:5.2.1.8]
synonym: "PPIase activity" EXACT [EC:5.2.1.8]
synonym: "rotamase activity" EXACT [EC:5.2.1.8]
xref: EC:5.2.1.8
xref: MetaCyc:PEPTIDYLPROLYL-ISOMERASE-RXN
is_a: GO:0016859 ! cis-trans isomerase activity
relationship: part_of GO:0000413 ! protein peptidyl-prolyl isomerization

[Term]
id: GO:0003756
name: protein disulfide isomerase activity
namespace: molecular_function
alt_id: GO:0006467
def: "Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins." [EC:5.3.4.1, GOC:vw, http://en.wikipedia.org/wiki/Protein_disulfide-isomerase#Function]
subset: gosubset_prok
synonym: "disulphide bond biosynthesis" EXACT []
synonym: "disulphide bond formation" EXACT []
synonym: "protein cysteine-thiol oxidation" RELATED []
synonym: "protein disulfide-isomerase" BROAD [EC:5.3.4.1]
synonym: "protein disulfide-isomerase reaction" EXACT [EC:5.3.4.1]
synonym: "protein disulphide isomerase activity" EXACT []
synonym: "protein thiol-disulfide exchange" EXACT []
synonym: "protein thiol-disulphide exchange" EXACT []
synonym: "S-S rearrangase activity" RELATED [EC:5.3.4.1]
xref: EC:5.3.4.1
xref: MetaCyc:5.3.4.1-RXN
is_a: GO:0016864 ! intramolecular oxidoreductase activity, transposing S-S bonds

[Term]
id: GO:0003759
name: obsolete glycoprotein-specific chaperone activity
namespace: molecular_function
def: "OBSOLETE. Assists in the correct, non-covalent assembly of glycoproteins in vivo, but is not a component of the assembled structures when performing its normal biological function. Utilizes a lectin site as a means to associate with the unfolded glycoproteins." [GOC:jl, PMID:11337494]
comment: This term was made obsolete because it represents a class of gene products and a biological process rather than a molecular function.
synonym: "glycoprotein-specific chaperone activity" EXACT []
is_obsolete: true
consider: GO:0006457
consider: GO:0044183
consider: GO:0051082

[Term]
id: GO:0003762
name: obsolete histone-specific chaperone activity
namespace: molecular_function
def: "OBSOLETE. Assists in chromatin assembly by chaperoning histones on to replicating DNA, but is not a component of the assembled nucleosome when performing its normal biological function." [GOC:jl, PMID:7600578, PMID:9325046]
comment: This term was made obsolete because it represents a class of gene products and a biological process rather than a molecular function.
synonym: "histone-specific chaperone activity" EXACT []
synonym: "nucleosome assembly chaperone" EXACT []
is_obsolete: true
consider: GO:0006333
consider: GO:0006334
consider: GO:0034728
consider: GO:0042393
consider: GO:0043486
consider: GO:0044183
consider: GO:0051082

[Term]
id: GO:0003763
name: obsolete chaperonin ATPase activity
namespace: molecular_function
alt_id: GO:0003764
alt_id: GO:0003765
alt_id: GO:0003766
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP involved in maintaining an unfolded polypeptide structure before folding or to entry into mitochondria and chloroplasts." [EC:3.6.4.9, ISBN:0198547684]
comment: This term was made obsolete because it represents a class of gene products, and its definition incorporates process information.
synonym: "chaperonin" EXACT []
synonym: "chaperonin ATPase activity" EXACT []
is_obsolete: true
replaced_by: GO:0042623
consider: GO:0006457

[Term]
id: GO:0003767
name: obsolete co-chaperone activity
namespace: molecular_function
alt_id: GO:0003768
alt_id: GO:0003769
alt_id: GO:0003770
alt_id: GO:0003771
def: "OBSOLETE. Co-chaperones are proteins that bind to chaperones and this complex then folds misfolded proteins. Co-chaperones by themselves do not possess chaperone activity." [GOC:rb]
comment: This term was made obsolete because it represents a class of gene products rather than a molecular function.
synonym: "co-chaperone activity" EXACT []
is_obsolete: true
consider: GO:0006457
consider: GO:0044183
consider: GO:0051087

[Term]
id: GO:0003772
name: obsolete co-chaperonin activity
namespace: molecular_function
def: "OBSOLETE. Co-chaperonins are proteins that bind to chaperones and this complex then folds misfolded proteins. Co-chaperonins by themselves do not possess chaperone activity." [GOC:rb]
comment: This term was made obsolete because it represents a class of gene products rather than a molecular function.
synonym: "co-chaperonin activity" EXACT []
is_obsolete: true
consider: GO:0006457
consider: GO:0044183
consider: GO:0051087

[Term]
id: GO:0003773
name: obsolete heat shock protein activity
namespace: molecular_function
def: "OBSOLETE. Any of a group of specific proteins that are synthesized by both prokaryotic and eukaryotic cells after they have been exposed to a temperature that is higher than normal. Other stresses, e.g. free radical damage, have a similar effect. Many members of the hsp family are not induced but are present in all cells. They are characterized by their role as molecular chaperones." [ISBN:0198547684]
comment: This term was made obsolete because it represents a class of gene products rather than a molecular function.
synonym: "heat shock protein activity" EXACT []
is_obsolete: true
consider: GO:0006986
consider: GO:0042026

[Term]
id: GO:0003774
name: motor activity
namespace: molecular_function
def: "Catalysis of the generation of force resulting either in movement along a microfilament or microtubule, or in torque resulting in membrane scission, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, GOC:vw, ISBN:0815316194, PMID:11242086]
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
is_a: GO:0017111 ! nucleoside-triphosphatase activity

[Term]
id: GO:0003775
name: obsolete axonemal motor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it includes cellular component information.
synonym: "axonemal motor activity" EXACT []
is_obsolete: true
consider: GO:0003777
consider: GO:0005930

[Term]
id: GO:0003776
name: obsolete muscle motor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it includes anatomy information.
synonym: "muscle motor activity" EXACT []
is_obsolete: true
replaced_by: GO:0000146
consider: GO:0006936
consider: GO:0043292

[Term]
id: GO:0003777
name: microtubule motor activity
namespace: molecular_function
def: "Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
comment: Consider also annotating to the molecular function term 'microtubule binding ; GO:0008017'.
synonym: "axonemal motor activity" NARROW []
synonym: "dynein" BROAD []
synonym: "dynein ATPase activity" NARROW []
synonym: "kinesin" BROAD []
synonym: "kinesin motor activity" NARROW []
synonym: "kinetochore motor activity" NARROW []
xref: Reactome:REACT_102513 "Axonal transport of NGF:Trk complexes, Danio rerio"
xref: Reactome:REACT_103791 "Translocation of Insulin Secretory Granules to Cell Cortex, Danio rerio"
xref: Reactome:REACT_105852 "Translocation of Insulin Secretory Granules to Cell Cortex, Bos taurus"
xref: Reactome:REACT_106252 "Translocation of Insulin Secretory Granules to Cell Cortex, Xenopus tropicalis"
xref: Reactome:REACT_113466 "Axonal transport of NGF:Trk complexes, Caenorhabditis elegans"
xref: Reactome:REACT_115371 "Translocation of Insulin Secretory Granules to Cell Cortex, Gallus gallus"
xref: Reactome:REACT_12385 "Axonal transport of NGF:Trk complexes, Homo sapiens"
xref: Reactome:REACT_15477 "Translocation of Insulin Secretory Granules to Cell Cortex, Homo sapiens"
xref: Reactome:REACT_20570 "Translocation of Insulin Secretory Granules to Cell Cortex, Mus musculus"
xref: Reactome:REACT_31982 "Axonal transport of NGF:Trk complexes, Sus scrofa"
xref: Reactome:REACT_32872 "Axonal transport of NGF:Trk complexes, Mus musculus"
xref: Reactome:REACT_33543 "Translocation of Insulin Secretory Granules to Cell Cortex, Rattus norvegicus"
xref: Reactome:REACT_77014 "Axonal transport of NGF:Trk complexes, Drosophila melanogaster"
xref: Reactome:REACT_78584 "Axonal transport of NGF:Trk complexes, Gallus gallus"
xref: Reactome:REACT_86678 "Translocation of Insulin Secretory Granules to Cell Cortex, Canis familiaris"
xref: Reactome:REACT_87390 "Axonal transport of NGF:Trk complexes, Bos taurus"
xref: Reactome:REACT_89365 "Axonal transport of NGF:Trk complexes, Taeniopygia guttata"
xref: Reactome:REACT_92428 "Translocation of Insulin Secretory Granules to Cell Cortex, Taeniopygia guttata"
xref: Reactome:REACT_94549 "Axonal transport of NGF:Trk complexes, Canis familiaris"
xref: Reactome:REACT_95164 "Axonal transport of NGF:Trk complexes, Xenopus tropicalis"
is_a: GO:0003774 ! motor activity

[Term]
id: GO:0003778
name: obsolete dynactin motor
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:hjd]
comment: This term was made obsolete because the dynactin complex is not a motor as such, but does regulate the dynein motor complex.
synonym: "dynactin motor" EXACT []
is_obsolete: true

[Term]
id: GO:0003779
name: actin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
synonym: "membrane associated actin binding" NARROW []
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0003780
name: obsolete actin cross-linking activity
namespace: molecular_function
def: "OBSOLETE. Interacting selectively with two actin filaments to anchor them together." [GOC:jid]
comment: This term was made obsolete because it represents a combination of molecular functions.
synonym: "actin cross-linking activity" EXACT []
is_obsolete: true
consider: GO:0030674
consider: GO:0051015

[Term]
id: GO:0003781
name: obsolete actin bundling activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a biological process.
synonym: "actin bundling activity" EXACT []
is_obsolete: true
replaced_by: GO:0051017

[Term]
id: GO:0003782
name: obsolete F-actin capping activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it describes a biological process.
synonym: "F-actin capping activity" EXACT []
is_obsolete: true
replaced_by: GO:0051016

[Term]
id: GO:0003783
name: obsolete barbed-end actin capping activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it describes a biological process.
synonym: "barbed-end actin capping activity" EXACT []
is_obsolete: true
replaced_by: GO:0051016

[Term]
id: GO:0003784
name: obsolete barbed-end actin capping/severing activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it describes two biological processes.
synonym: "barbed-end actin capping/severing activity" EXACT []
is_obsolete: true
consider: GO:0051014
consider: GO:0051016

[Term]
id: GO:0003785
name: actin monomer binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with monomeric actin, also known as G-actin." [GOC:ai]
synonym: "G actin binding" EXACT []
is_a: GO:0003779 ! actin binding

[Term]
id: GO:0003786
name: actin lateral binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an actin filament along its length." [GOC:mah]
is_a: GO:0051015 ! actin filament binding

[Term]
id: GO:0003787
name: obsolete actin depolymerizing activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a biological process.
synonym: "actin depolymerizing activity" EXACT []
is_obsolete: true
replaced_by: GO:0030042

[Term]
id: GO:0003788
name: obsolete actin monomer sequestering activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because sequestering is a process, not an activity.
synonym: "actin monomer sequestering activity" EXACT []
is_obsolete: true
replaced_by: GO:0042989

[Term]
id: GO:0003789
name: obsolete actin filament severing activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it describes a biological process.
synonym: "actin filament severing activity" EXACT []
is_obsolete: true
replaced_by: GO:0051014

[Term]
id: GO:0003790
name: obsolete actin modulating activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it does not make sense.
synonym: "actin modulating activity" EXACT []
is_obsolete: true
consider: GO:0030036

[Term]
id: GO:0003791
name: obsolete membrane associated actin binding
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it contains both component and function information.
synonym: "membrane associated actin binding" EXACT []
is_obsolete: true
consider: GO:0003779
consider: GO:0016020

[Term]
id: GO:0003792
name: obsolete regulation of actin thin filament length activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because the term belongs in the process ontology.
synonym: "regulation of actin thin filament length activity" EXACT []
is_obsolete: true
replaced_by: GO:0030832

[Term]
id: GO:0003793
name: obsolete defense/immunity protein activity
namespace: molecular_function
def: "OBSOLETE. Any activity that plays a role in the defense/immune response of an organism against infection and disease." [GOC:go_curators]
comment: This term was made obsolete because it refers to involvement in a biological process.
synonym: "defence/immunity protein activity" EXACT []
synonym: "defense/immunity protein activity" EXACT []
is_obsolete: true
consider: GO:0006952

[Term]
id: GO:0003794
name: obsolete acute-phase response protein activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it refers to involvement in a biological process.
synonym: "acute-phase response protein activity" EXACT []
is_obsolete: true
consider: GO:0006953

[Term]
id: GO:0003795
name: obsolete antimicrobial peptide activity
namespace: molecular_function
def: "OBSOLETE. Inhibits the growth of, or directly kills, microbial cells." [GOC:go_curators]
comment: This term was made obsolete because it describes involvement in a process and not a function.
synonym: "antimicrobial peptide activity" EXACT []
is_obsolete: true
consider: GO:0019730

[Term]
id: GO:0003796
name: lysozyme activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins." [EC:3.2.1.17]
subset: gosubset_prok
synonym: "1,4-N-acetylmuramidase activity" EXACT []
synonym: "globulin G" RELATED [EC:3.2.1.17]
synonym: "globulin G1" RELATED [EC:3.2.1.17]
synonym: "L-7001" RELATED [EC:3.2.1.17]
synonym: "lysozyme g" RELATED [EC:3.2.1.17]
synonym: "mucopeptide glucohydrolase activity" EXACT []
synonym: "mucopeptide N-acetylmuramoylhydrolase activity" EXACT []
synonym: "muramidase activity" EXACT []
synonym: "N,O-diacetylmuramidase activity" EXACT []
synonym: "peptidoglycan N-acetylmuramoylhydrolase activity" EXACT [EC:3.2.1.17]
synonym: "PR1-lysozyme" RELATED [EC:3.2.1.17]
xref: EC:3.2.1.17
xref: MetaCyc:3.2.1.17-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0003797
name: obsolete antibacterial peptide activity
namespace: molecular_function
def: "OBSOLETE. Inhibits the growth of, or directly kills, bacterial cells." [GOC:go_curators]
comment: This term was made obsolete because it describes involvement in a process and not a function.
synonym: "antibacterial peptide activity" EXACT []
is_obsolete: true
consider: GO:0042742

[Term]
id: GO:0003798
name: obsolete male-specific antibacterial peptide activity
namespace: molecular_function
def: "OBSOLETE. Inhibits the growth of, or directly kills, bacterial cells, but which is only expressed in males." [GOC:go_curators]
comment: This term was made obsolete because it describes involvement in a process and not a function.
synonym: "male-specific antibacterial peptide activity" EXACT []
is_obsolete: true
consider: GO:0050831

[Term]
id: GO:0003799
name: obsolete antifungal peptide activity
namespace: molecular_function
def: "OBSOLETE. Inhibits the growth of, or directly kills, fungal cells." [GOC:go_curators]
comment: This term was made obsolete because it describes involvement in a process and not a function.
synonym: "antifungal peptide activity" EXACT []
is_obsolete: true
consider: GO:0050832

[Term]
id: GO:0003800
name: obsolete antiviral response protein activity
namespace: molecular_function
def: "OBSOLETE. A protein involved in an antiviral response." [GOC:ai]
comment: This term was made obsolete because it refers to involvement in a biological process.
synonym: "antiviral response protein activity" EXACT []
is_obsolete: true
consider: GO:0009615

[Term]
id: GO:0003801
name: obsolete blood coagulation factor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it refers to involvement in a biological process.
synonym: "blood coagulation factor activity" EXACT []
is_obsolete: true
consider: GO:0004252
consider: GO:0007596

[Term]
id: GO:0003802
name: obsolete coagulation factor VIIa activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the selective cleavage of one Arg-Ile bond in factor X to form factor Xa, and on factor IX to form factor IXa beta." [EC:3.4.21.21, PMID:12496253]
comment: This term was made obsolete because it represents a gene product.
synonym: "activated blood coagulation factor VII" RELATED [EC:3.4.21.21]
synonym: "blood coagulation factor VII activity" EXACT []
synonym: "blood-coagulation factor VIIa" RELATED [EC:3.4.21.21]
synonym: "coagulation factor VIIa activity" EXACT []
xref: EC:3.4.21.21
xref: MetaCyc:3.4.21.21-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003803
name: obsolete coagulation factor IXa activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the selective cleavage of the Arg-Ile bond in factor X to form factor Xa." [EC:3.4.21.22]
comment: This term was made obsolete because it represents a gene product.
synonym: "activated blood coagulation factor XI" RELATED [EC:3.4.21.22]
synonym: "activated blood-coagulation factor IX" RELATED [EC:3.4.21.22]
synonym: "activated christmas factor" RELATED [EC:3.4.21.22]
synonym: "autoprothrombin II" RELATED [EC:3.4.21.22]
synonym: "blood coagulation factor IX activity" EXACT []
synonym: "blood platelet cofactor II" RELATED [EC:3.4.21.22]
synonym: "blood-coagulation factor IXa" RELATED [EC:3.4.21.22]
synonym: "Christmas factor activity" EXACT [EC:3.4.21.22]
synonym: "coagulation factor IXa activity" EXACT []
xref: EC:3.4.21.22
xref: MetaCyc:3.4.21.22-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003804
name: obsolete coagulation factor Xa activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Thr and then Arg-Ile bonds in prothrombin to form thrombin, and on factor VII, which it converts to a two-chain form (factor VIIa)." [EC:3.4.21.6, GOC:jl, PMID:7354023]
comment: This term was made obsolete because it represents a gene product.
synonym: "activated blood-coagulation factor X" RELATED [EC:3.4.21.6]
synonym: "activated factor X" RELATED [EC:3.4.21.6]
synonym: "activated Stuart-Prower factor" RELATED [EC:3.4.21.6]
synonym: "autoprothrombin C" RELATED [EC:3.4.21.6]
synonym: "blood coagulation factor X activity" EXACT []
synonym: "coagulation factor Xa activity" EXACT []
synonym: "factor Xa" RELATED [EC:3.4.21.6]
synonym: "plasma thromboplastin" RELATED [EC:3.4.21.6]
synonym: "prothrombase activity" EXACT [EC:3.4.21.6]
synonym: "prothrombinase activity" EXACT [EC:3.4.21.6]
synonym: "Stuart factor" RELATED [EC:3.4.21.6]
synonym: "Stuart factor activity" EXACT [EC:3.4.21.6]
synonym: "thrombokinase activity" EXACT [EC:3.4.21.6]
synonym: "thromboplastin" RELATED [EC:3.4.21.6]
xref: EC:3.4.21.6
xref: MetaCyc:3.4.21.6-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003805
name: obsolete coagulation factor XIa activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the selective cleavage of Arg-Ala and Arg-Val bonds in factor IX to form factor IXa." [EC:3.4.21.27]
comment: This term was made obsolete because it represents a gene product.
synonym: "activated blood-coagulation factor XI" RELATED [EC:3.4.21.27]
synonym: "activated plasma thromboplastin antecedent" RELATED [EC:3.4.21.27]
synonym: "blood coagulation factor XI activity" EXACT []
synonym: "blood-coagulation factor XIa" RELATED [EC:3.4.21.27]
synonym: "coagulation factor XIa activity" EXACT []
synonym: "plasma thromboplastin antecedent activity" EXACT [EC:3.4.21.27]
xref: EC:3.4.21.27
xref: MetaCyc:3.4.21.27-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003806
name: obsolete coagulation factor XIIa activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the selective cleavage of Arg-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa." [EC:3.4.21.38]
comment: This term was made obsolete because it represents a gene product.
synonym: "activated beta blood-coagulation factor XII" RELATED [EC:3.4.21.38]
synonym: "blood coagulation factor XII activity" EXACT []
synonym: "blood-coagulation factor XIIabeta" RELATED [EC:3.4.21.38]
synonym: "blood-coagulation factor XIIf" RELATED [EC:3.4.21.38]
synonym: "coagulation factor XIIa activity" EXACT []
synonym: "hageman factor (activated)" RELATED [EC:3.4.21.38]
synonym: "hageman factor activity" EXACT [EC:3.4.21.38]
synonym: "hageman factor beta-fragment" RELATED [EC:3.4.21.38]
synonym: "hageman factor fragment HFf" RELATED [EC:3.4.21.38]
synonym: "kallikreinogen activator" RELATED [EC:3.4.21.38]
synonym: "prealbumin activator" RELATED [EC:3.4.21.38]
synonym: "prekallikrein activator" RELATED [EC:3.4.21.38]
xref: EC:3.4.21.38
xref: MetaCyc:3.4.21.38-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003807
name: obsolete plasma kallikrein activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the selective cleavage of Arg-Xaa and Lys-Xaa bonds, including Lys-Arg and Arg-Ser bonds in (human) kininogen to release bradykinin." [EC:3.4.21.34]
comment: This term was made obsolete because it represents a gene product.
synonym: "bradykininogenase" BROAD [EC:3.4.21.34]
synonym: "callicrein" RELATED [EC:3.4.21.34]
synonym: "depot-padutin" RELATED [EC:3.4.21.34]
synonym: "dilminal D" RELATED [EC:3.4.21.34]
synonym: "glumorin" RELATED [EC:3.4.21.34]
synonym: "kallidinogenase" BROAD [EC:3.4.21.34]
synonym: "kallikrein" RELATED [EC:3.4.21.34]
synonym: "kallikrein I" RELATED [EC:3.4.21.34]
synonym: "kallikrein II" RELATED [EC:3.4.21.34]
synonym: "kininogenase" BROAD [EC:3.4.21.34]
synonym: "kininogenin activity" RELATED [EC:3.4.21.34]
synonym: "onokrein P" RELATED [EC:3.4.21.34]
synonym: "padreatin" RELATED [EC:3.4.21.34]
synonym: "padutin" RELATED [EC:3.4.21.34]
synonym: "panceatic kallikrein" RELATED [EC:3.4.21.34]
synonym: "plasma kallikrein activity" EXACT []
synonym: "serum kallikrein activity" EXACT [EC:3.4.21.34]
synonym: "urinary kallikrein" RELATED [EC:3.4.21.34]
synonym: "urokallikrein" RELATED [EC:3.4.21.34]
xref: EC:3.4.21.34
xref: MetaCyc:3.4.21.34-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003808
name: obsolete protein C (activated) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the degradation of blood coagulation factors Va and VIIIa." [EC:3.4.21.69]
comment: This term was made obsolete because it represents a gene product.
synonym: "activated blood coagulation factor XIV activity" EXACT [EC:3.4.21.69]
synonym: "activated protein C" RELATED [EC:3.4.21.69]
synonym: "autoprothrombin II-A" RELATED [EC:3.4.21.69]
synonym: "autoprothrombin IIA activity" EXACT [EC:3.4.21.69]
synonym: "blood-coagulation factor XIVa" RELATED [EC:3.4.21.69]
synonym: "GSAPC" RELATED [EC:3.4.21.69]
synonym: "protein C (activated) activity" EXACT []
synonym: "protein Ca" RELATED [EC:3.4.21.69]
xref: EC:3.4.21.69
xref: MetaCyc:3.4.21.69-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003809
name: obsolete thrombin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Gly; activates fibrinogen to fibrin and releases fibrinopeptide A and B." [EC:3.4.21.5]
comment: This term was made obsolete because it represents a gene product.
synonym: "activated blood-coagulation factor II" RELATED [EC:3.4.21.5]
synonym: "beta-thrombin" RELATED [EC:3.4.21.5]
synonym: "blood-coagulation factor IIa" RELATED [EC:3.4.21.5]
synonym: "E thrombin" RELATED [EC:3.4.21.5]
synonym: "factor IIa" RELATED [EC:3.4.21.5]
synonym: "fibrinogenase activity" EXACT [EC:3.4.21.5]
synonym: "gamma-thrombin" RELATED [EC:3.4.21.5]
synonym: "thrombase activity" EXACT [EC:3.4.21.5]
synonym: "thrombin activity" EXACT []
synonym: "thrombin-C" RELATED [EC:3.4.21.5]
synonym: "thrombofort" RELATED [EC:3.4.21.5]
synonym: "topical" RELATED [EC:3.4.21.5]
synonym: "tropostasin" RELATED [EC:3.4.21.5]
xref: EC:3.4.21.5
xref: MetaCyc:3.4.21.5-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003810
name: protein-glutamine gamma-glutamyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links." [EC:2.3.2.13, RESID:AA0124]
subset: gosubset_prok
synonym: "factor XIIIa" RELATED [EC:2.3.2.13]
synonym: "fibrin stabilizing factor" RELATED [EC:2.3.2.13]
synonym: "fibrinoligase activity" EXACT []
synonym: "glutaminylpeptide gamma-glutamyltransferase activity" EXACT [EC:2.3.2.13]
synonym: "polyamine transglutaminase activity" RELATED [EC:2.3.2.13]
synonym: "protein-glutamine:amine gamma-glutamyltransferase" EXACT [EC:2.3.2.13]
synonym: "R-glutaminyl-peptide:amine gamma-glutamyl transferase activity" EXACT [EC:2.3.2.13]
synonym: "TGase activity" EXACT []
synonym: "tissue transglutaminase" NARROW [EC:2.3.2.13]
synonym: "transglutaminase activity" EXACT []
xref: EC:2.3.2.13
xref: MetaCyc:2.3.2.13-RXN
xref: Reactome:REACT_101525 "fibrin multimer -> fibrin multimer, crosslinked + NH4+, Canis familiaris"
xref: Reactome:REACT_112106 "fibrin multimer -> fibrin multimer, crosslinked + NH4+, Drosophila melanogaster"
xref: Reactome:REACT_112367 "fibrin multimer -> fibrin multimer, crosslinked + NH4+, Sus scrofa"
xref: Reactome:REACT_112902 "fibrin multimer -> fibrin multimer, crosslinked + NH4+, Xenopus tropicalis"
xref: Reactome:REACT_1852 "fibrin multimer -> fibrin multimer, crosslinked + NH4+, Homo sapiens"
xref: Reactome:REACT_37344 "fibrin multimer -> fibrin multimer, crosslinked + NH4+, Gallus gallus"
xref: Reactome:REACT_82525 "fibrin multimer -> fibrin multimer, crosslinked + NH4+, Bos taurus"
xref: Reactome:REACT_82887 "fibrin multimer -> fibrin multimer, crosslinked + NH4+, Rattus norvegicus"
xref: Reactome:REACT_89774 "fibrin multimer -> fibrin multimer, crosslinked + NH4+, Danio rerio"
xref: Reactome:REACT_97354 "fibrin multimer -> fibrin multimer, crosslinked + NH4+, Taeniopygia guttata"
xref: Reactome:REACT_98243 "fibrin multimer -> fibrin multimer, crosslinked + NH4+, Mus musculus"
xref: RESID:AA0124
is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups

[Term]
id: GO:0003811
name: obsolete complement activity
namespace: molecular_function
def: "OBSOLETE. Any of a set of activities involved in the complement cascade." [GOC:jl]
comment: This term was made obsolete because it refers to involvement in a biological process.
synonym: "complement activity" EXACT []
is_obsolete: true
consider: GO:0006956

[Term]
id: GO:0003812
name: obsolete alternative-complement-pathway C3/C5 convertase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of Arg-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg bond in complement component C5 alpha-chain to yield C5a and C5b." [EC:3.4.21.47]
comment: This term was made obsolete because it represents a gene product.
synonym: "(C3b)n,Bb" RELATED [EC:3.4.21.47]
synonym: "(CVF)-dependent glycine-rich-beta-glucoprotein" RELATED [EC:3.4.21.47]
synonym: "alternative complement pathway C3(C5) convertase activity" EXACT [EC:3.4.21.47]
synonym: "alternative-complement-pathway C3/C5 convertase activity" EXACT []
synonym: "C3 convertase activity" BROAD [EC:3.4.21.47]
synonym: "C3 proactivator" RELATED [EC:3.4.21.47]
synonym: "C3b,Bb,CVF,Bb,C5 convertase activity" EXACT [EC:3.4.21.47]
synonym: "C5 convertase activity" BROAD [EC:3.4.21.47]
synonym: "cobra venom factor-dependent C3 convertase" NARROW [EC:3.4.21.47]
synonym: "complement C 3(C 5) convertase (amplification)" EXACT [EC:3.4.21.47]
synonym: "complement component C3/C5 convertase (alternative) activity" EXACT [EC:3.4.21.47]
synonym: "complement factor B activity" EXACT [EC:3.4.21.47]
synonym: "CVF,Bb" RELATED [EC:3.4.21.47]
synonym: "glycine-rich beta-glycoprotein" RELATED [EC:3.4.21.47]
synonym: "heat-labile factor" RELATED [EC:3.4.21.47]
synonym: "proenzyme factor B" EXACT []
synonym: "properdin factor B activity" EXACT [EC:3.4.21.47]
xref: EC:3.4.21.47
xref: MetaCyc:3.4.21.47-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003813
name: obsolete classical-complement-pathway C3/C5 convertase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the selective cleavage of Arg-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg bond in complement component C5 alpha-chain to form C5a and C5b." [EC:3.4.21.43]
comment: This term was made obsolete because it represents a gene product.
synonym: "C3 convertase activity" BROAD [EC:3.4.21.43]
synonym: "C42" RELATED [EC:3.4.21.43]
synonym: "C423" RELATED [EC:3.4.21.43]
synonym: "C4b,2a" RELATED [EC:3.4.21.43]
synonym: "C4b,2a,3b" RELATED [EC:3.4.21.43]
synonym: "C5 convertase activity" BROAD [EC:3.4.21.43]
synonym: "classical-complement-pathway C3/C5 convertase activity" EXACT []
synonym: "complement C2 activity" BROAD [EC:3.4.21.43]
synonym: "complement C3 convertase activity" EXACT [EC:3.4.21.43]
synonym: "complement C42" RELATED [EC:3.4.21.43]
xref: EC:3.4.21.43
xref: MetaCyc:3.4.21.43-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003815
name: obsolete complement component C1r activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the selective cleavage of Lys(or Arg)-Ile bond in complement subcomponent C1s to form the active form of C1s (EC:3.4.21.42)." [EC:3.4.21.41]
comment: This term was made obsolete because it represents a gene product.
synonym: "activated complement C1r" RELATED [EC:3.4.21.41]
synonym: "C1r esterase activity" EXACT [EC:3.4.21.41]
synonym: "complement component C1r activity" EXACT []
synonym: "complement subcomponent C1r" RELATED [EC:3.4.21.41]
xref: EC:3.4.21.41
xref: MetaCyc:3.4.21.41-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003816
name: obsolete complement component C1s activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of component C4 to C4a and C4b (Arg-Ala bond), and component C2 to C2a and C2b (Lys-Lys or Arg-Lys bond)." [EC:3.4.21.42]
comment: This term was made obsolete because it represents a gene product.
synonym: "activated complement C1s" RELATED [EC:3.4.21.42]
synonym: "C1 esterase activity" EXACT [EC:3.4.21.42]
synonym: "C1s esterase activity" EXACT [EC:3.4.21.42]
synonym: "complement C1s" RELATED [EC:3.4.21.42]
synonym: "complement component C1s activity" EXACT []
synonym: "complement subcomponent C1s" RELATED [EC:3.4.21.42]
xref: EC:3.4.21.42
xref: MetaCyc:3.4.21.42-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003817
name: obsolete complement factor D activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of component factor B (Arg-Lys) when in complex with C3b or with cobra venom factor (CVF)." [EC:3.4.21.46]
comment: This term was made obsolete because it represents a gene product.
synonym: "adipsin" EXACT []
synonym: "C3 convertase activator activity" EXACT [EC:3.4.21.46]
synonym: "C3 proactivator convertase activity" EXACT [EC:3.4.21.46]
synonym: "complement factor D activity" EXACT []
synonym: "factor D" RELATED [EC:3.4.21.46]
synonym: "factor D (complement)" RELATED [EC:3.4.21.46]
synonym: "properdin factor D esterase activity" EXACT [EC:3.4.21.46]
xref: EC:3.4.21.46
xref: MetaCyc:3.4.21.46-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003818
name: obsolete complement factor I activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the inactivation of complement subcomponents C3b, iC3b and C4b by proteolytic cleavage." [EC:3.4.21.45]
comment: This term was made obsolete because it represents a gene product.
synonym: "C3b inactivator activity" NARROW [EC:3.4.21.45]
synonym: "C3b/C4b inactivator activity" EXACT [EC:3.4.21.45]
synonym: "C3bINA" RELATED [EC:3.4.21.45]
synonym: "complement C3b inactivator" RELATED [EC:3.4.21.45]
synonym: "complement C3b/C4b inactivator" RELATED [EC:3.4.21.45]
synonym: "complement C4b inactivator" RELATED [EC:3.4.21.45]
synonym: "complement C4bi" RELATED [EC:3.4.21.45]
synonym: "complement component C3b inactivator activity" EXACT [EC:3.4.21.45]
synonym: "complement factor I activity" EXACT []
synonym: "conglutinogen-activating factor C" RELATED [EC:3.4.21.45]
synonym: "factor I" RELATED [EC:3.4.21.45]
xref: EC:3.4.21.45
xref: MetaCyc:3.4.21.45-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003819
name: obsolete major histocompatibility complex antigen
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity.
synonym: "major histocompatibility complex antigen" EXACT []
synonym: "MHC protein" EXACT []
is_obsolete: true

[Term]
id: GO:0003820
name: obsolete class I major histocompatibility complex antigen
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity.
synonym: "class I major histocompatibility complex antigen" EXACT []
is_obsolete: true
consider: GO:0042612

[Term]
id: GO:0003821
name: obsolete class II major histocompatibility complex antigen
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity.
synonym: "class II major histocompatibility complex antigen" EXACT []
is_obsolete: true
consider: GO:0042613

[Term]
id: GO:0003822
name: obsolete MHC-interacting protein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "MHC-interacting protein" EXACT []
is_obsolete: true

[Term]
id: GO:0003823
name: antigen binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen." [GOC:jl, ISBN:0198506732, ISBN:0721662544]
subset: goslim_chembl
subset: goslim_pir
synonym: "antibody" RELATED []
synonym: "B cell receptor activity" RELATED []
synonym: "immunoglobulin" RELATED []
synonym: "opsonin activity" RELATED []
is_a: GO:0005488 ! binding

[Term]
id: GO:0003824
name: catalytic activity
namespace: molecular_function
def: "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
subset: goslim_chembl
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "enzyme activity" EXACT [GOC:dph, GOC:tb]
xref: Wikipedia:Enzyme
is_a: GO:0003674 ! molecular_function
relationship: part_of GO:0008152 ! metabolic process

[Term]
id: GO:0003825
name: alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + D-glucose-6-phosphate = UDP + alpha,alpha-trehalose-6-phosphate." [EC:2.4.1.15]
subset: gosubset_prok
synonym: "alpha,alpha-trehalose phosphate synthase (UDP-forming)" EXACT [EC:2.4.1.15]
synonym: "phosphotrehalose-uridine diphosphate transglucosylase activity" EXACT [EC:2.4.1.15]
synonym: "transglucosylase activity" EXACT []
synonym: "trehalose 6-phosphate synthase activity" EXACT []
synonym: "trehalose 6-phosphate synthetase activity" EXACT []
synonym: "trehalose phosphate synthase activity" EXACT [EC:2.4.1.15]
synonym: "trehalose phosphate synthetase activity" EXACT [EC:2.4.1.15]
synonym: "trehalose phosphate-uridine diphosphate glucosyltransferase activity" EXACT [EC:2.4.1.15]
synonym: "trehalose-P synthetase activity" EXACT [EC:2.4.1.15]
synonym: "trehalose-phosphate synthase activity" EXACT []
synonym: "trehalose-phosphate synthetase activity" EXACT []
synonym: "trehalosephosphate-UDP glucosyl transferase activity" EXACT []
synonym: "trehalosephosphate-UDP glucosyltransferase activity" EXACT []
synonym: "UDP-glucose-glucose-phosphate glucosyltransferase activity" EXACT []
synonym: "UDP-glucose-glucosephosphate glucosyltransferase activity" EXACT [EC:2.4.1.15]
synonym: "UDP-glucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity" EXACT []
synonym: "UDPglucose-glucose-phosphate glucosyltransferase activity" EXACT [EC:2.4.1.15]
synonym: "UDPglucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.15]
synonym: "uridine diphosphoglucose phosphate glucosyltransferase activity" EXACT [EC:2.4.1.15]
xref: EC:2.4.1.15
xref: MetaCyc:TREHALOSE6PSYN-RXN
xref: Reactome:REACT_27138 "Glucose is transferred from UDP-glucose onto glucose-6-phosphate, Mycobacterium tuberculosis"
xref: RHEA:18892
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0003826
name: alpha-ketoacid dehydrogenase activity
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction involving an alpha-ketoacid." [GOC:mah]
subset: gosubset_prok
xref: Reactome:REACT_101696 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Drosophila melanogaster"
xref: Reactome:REACT_101855 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Plasmodium falciparum"
xref: Reactome:REACT_102398 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Taeniopygia guttata"
xref: Reactome:REACT_109062 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Canis familiaris"
xref: Reactome:REACT_113399 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Mycobacterium tuberculosis"
xref: Reactome:REACT_1813 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Homo sapiens"
xref: Reactome:REACT_30155 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Oryza sativa"
xref: Reactome:REACT_30632 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Gallus gallus"
xref: Reactome:REACT_30883 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Caenorhabditis elegans"
xref: Reactome:REACT_33771 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Xenopus tropicalis"
xref: Reactome:REACT_34024 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Bos taurus"
xref: Reactome:REACT_34280 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Arabidopsis thaliana"
xref: Reactome:REACT_81262 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Staphylococcus aureus N315"
xref: Reactome:REACT_86541 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Sus scrofa"
xref: Reactome:REACT_88849 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Mus musculus"
xref: Reactome:REACT_92556 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Danio rerio"
xref: Reactome:REACT_95085 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Rattus norvegicus"
xref: Reactome:REACT_96212 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Dictyostelium discoideum"
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0003827
name: alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-(alpha-D-mannosyl)-beta-D-mannosyl-R + UDP-N-acetyl-alpha-D-glucosamine = 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R + H(+) + UDP." [EC:2.4.1.101, RHEA:11459]
synonym: "alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.101]
synonym: "alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.101]
synonym: "alpha-1,3-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" EXACT []
synonym: "GnTI" RELATED [EC:2.4.1.101]
synonym: "GNTI activity" EXACT [EC:2.4.1.101]
synonym: "N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.101]
synonym: "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.101]
synonym: "UDP-N-acetyl-D-glucosamine:3-(alpha-D-mannosyl)-beta-D-mannosyl-glycoprotein 2-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.101]
synonym: "UDP-N-acetylglucosaminyl:alpha-1,3-D-mannoside-beta-1,2-N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.101]
synonym: "UDP-N-acetylglucosaminyl:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.101]
synonym: "uridine diphosphoacetylglucosamine-alpha-1,3-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.101]
xref: EC:2.4.1.101
xref: KEGG:R05983
xref: MetaCyc:2.4.1.101-RXN
xref: Reactome:REACT_25236 "Addition of GlcNAc to the glycan on the A arm, Homo sapiens"
xref: RHEA:11459
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0003828
name: alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R." [EC:2.4.99.8]
synonym: "alpha-2,8-sialyltransferase activity" EXACT [EC:2.4.99.8]
synonym: "alpha-N-acetylneuraminide alpha-2,8-sialyltransferase activity" EXACT []
synonym: "CMP-N-acetylneuraminate:alpha-N-acetylneuraminyl-2,3-beta-D-galactoside alpha-2,8-N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.8]
synonym: "CMP-NeuAc:LM1 alpha-(2->8)-sialyltranferase activity" EXACT [EC:2.4.99.8]
synonym: "CMP-NeuAc:LM1(alpha-2,8) sialyltranferase activity" EXACT [EC:2.4.99.8]
synonym: "cytidine monophosphoacetylneuraminate-ganglioside GM3" RELATED [EC:2.4.99.8]
synonym: "ganglioside GD3 synthase activity" EXACT [EC:2.4.99.8]
synonym: "ganglioside GD3 synthetase sialyltransferase activity" EXACT [EC:2.4.99.8]
synonym: "GD3 synthase activity" EXACT [EC:2.4.99.8]
synonym: "SAT-2" RELATED [EC:2.4.99.8]
xref: EC:2.4.99.8
xref: MetaCyc:2.4.99.8-RXN
xref: Reactome:REACT_103372 "Polysialylation of NCAM1, Canis familiaris"
xref: Reactome:REACT_103428 "Polysialylation of NCAM1, Taeniopygia guttata"
xref: Reactome:REACT_104790 "Polysialylation of NCAM1, Sus scrofa"
xref: Reactome:REACT_105388 "Polysialylation of NCAM1, Rattus norvegicus"
xref: Reactome:REACT_110734 "Polysialylation of NCAM1, Xenopus tropicalis"
xref: Reactome:REACT_18324 "Polysialylation of NCAM1, Homo sapiens"
xref: Reactome:REACT_25115 "Addition of alpha-2,8-sialic acid to N-glycan over a galactose by ST8SIAs, Homo sapiens"
xref: Reactome:REACT_32138 "Polysialylation of NCAM1, Danio rerio"
xref: Reactome:REACT_34632 "Polysialylation of NCAM1, Gallus gallus"
xref: Reactome:REACT_85065 "Polysialylation of NCAM1, Bos taurus"
xref: Reactome:REACT_86310 "Polysialylation of NCAM1, Mus musculus"
xref: RHEA:19316
is_a: GO:0008373 ! sialyltransferase activity

[Term]
id: GO:0003829
name: beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R = UDP + beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-D-galactosaminyl-R." [EC:2.4.1.102]
synonym: "beta(6)-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.102]
synonym: "beta6-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.102]
synonym: "core 2 acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.102]
synonym: "core 6-beta-GlcNAc-transferase A" RELATED [EC:2.4.1.102]
synonym: "O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.102]
synonym: "UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R) beta-1,6-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.102]
synonym: "uridine diphosphoacetylglucosamine-mucin beta-(1,6)-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.102]
synonym: "uridine diphosphoacetylglucosamine-mucin beta-(1->6)-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.102]
xref: EC:2.4.1.102
xref: MetaCyc:2.4.1.102-RXN
xref: Reactome:REACT_115554 "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein, Homo sapiens"
xref: Reactome:REACT_115905 "Addition of GlcNAc to the T antigen forms a Core 2 glycoprotein, Homo sapiens"
xref: RHEA:18708
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0003830
name: beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R = UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R." [EC:2.4.1.144]
subset: gosubset_prok
synonym: "beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.144]
synonym: "beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.144]
synonym: "GnTIII activity" EXACT [EC:2.4.1.144]
synonym: "N-acetylglucosaminyltransferase III activity" EXACT [EC:2.4.1.144]
synonym: "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III activity" EXACT [EC:2.4.1.144]
synonym: "UDP-N-acetyl-D-glucosamine:beta-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.144]
synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta-4-acetylglucosaminyltransferase III activity" EXACT [EC:2.4.1.144]
synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase III" RELATED [EC:2.4.1.144]
xref: EC:2.4.1.144
xref: MetaCyc:2.4.1.144-RXN
xref: Reactome:REACT_25005 "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3, Homo sapiens"
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0003831
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide." [EC:2.4.1.38]
synonym: "beta-N-acetyl-beta-(1,4)-galactosyltransferase activity" EXACT [EC:2.4.1.38]
synonym: "beta-N-acetyl-beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.38]
synonym: "GalT activity" RELATED [EC:2.4.1.38]
synonym: "glycoprotein 4-beta-galactosyl-transferase activity" EXACT [EC:2.4.1.38]
synonym: "glycoprotein 4-beta-galactosyltransferase activity" EXACT [EC:2.4.1.38]
synonym: "glycoprotein beta-galactosyltransferase activity" EXACT [EC:2.4.1.38]
synonym: "thyroid galactosyltransferase activity" NARROW [EC:2.4.1.38]
synonym: "thyroid glycoprotein beta-galactosyltransferase" NARROW [EC:2.4.1.38]
synonym: "UDP-galactose--glycoprotein galactosyltransferase activity" EXACT [EC:2.4.1.38]
synonym: "UDP-galactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.38]
synonym: "UDPgalactose-glycoprotein galactosyltransferase activity" EXACT [EC:2.4.1.38]
synonym: "UDPgalactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.38]
synonym: "uridine diphosphogalactose-glycoprotein galactosyltransferase activity" EXACT [EC:2.4.1.38]
xref: EC:2.4.1.38
xref: MetaCyc:2.4.1.38-RXN
xref: Reactome:REACT_25178 "Addition of galactose by beta 4-galactosyltransferases, Homo sapiens"
xref: RHEA:22935
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0003832
name: beta-alanyl-dopamine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-beta-alanyl dopamine + H2O = dopamine + beta-alanine." [GOC:bf, ISBN:0198506732, PMID:12957543]
synonym: "N-beta-alanyl-dopamine hydrolase activity" EXACT []
synonym: "NBAD hydrolase activity" EXACT []
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0003833
name: beta-alanyl-dopamine synthase activity
namespace: molecular_function
def: "Catalysis of the synthesis of beta-alanyl-dopamine from the precursor dopamine (3,4-dihydroxyphenylethylamine)." [GOC:bf, ISBN:0198506732, PMID:12957543]
synonym: "N-beta-alanyl dopamine synthetase activity" EXACT []
synonym: "NBAD transferase activity" EXACT []
is_a: GO:0016874 ! ligase activity

[Term]
id: GO:0003834
name: beta-carotene 15,15'-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-carotene + O(2) = 2 retinal." [EC:1.14.99.36, RHEA:10407]
comment: Note that this function was formerly EC:1.13.11.21.
synonym: "beta-carotene 15,15'-dioxygenase activity" EXACT []
synonym: "beta-carotene:oxygen 15,15'-oxidoreductase (bond-cleaving)" EXACT [EC:1.14.99.36]
synonym: "carotene 15,15'-dioxygenase activity" EXACT [EC:1.14.99.36]
synonym: "carotene dioxygenase activity" EXACT [EC:1.14.99.36]
xref: EC:1.14.99.36
xref: KEGG:R00032
xref: MetaCyc:BETA-CAROTENE-1515-DIOXYGENASE-RXN
xref: Reactome:REACT_25117 "Oxidation of beta-carotene to retinal, Homo sapiens"
xref: RHEA:10407
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0003835
name: beta-galactoside alpha-2,6-sialyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine." [EC:2.4.99.1]
synonym: "beta-galactosamide alpha-2,6-sialyltransferase activity" EXACT []
synonym: "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase activity" EXACT [EC:2.4.99.1]
synonym: "CMP-N-acetylneuraminate:beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine alpha-2,6-N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.1]
xref: EC:2.4.99.1
xref: MetaCyc:2.4.99.1-RXN
xref: Reactome:REACT_115891 "Sialyltransferase I can add sialic acid to the T antigen at the alpha 6 position, Homo sapiens"
xref: Reactome:REACT_115991 "Sialyltransferase I can add sialic acid to the Tn antigen at the alpha 6 position, Homo sapiens"
xref: Reactome:REACT_24990 "Addition of alpha-2,6-sialic acid to terminal galactose of N-glycans by ST6GAL1, Homo sapiens"
xref: RHEA:11839
is_a: GO:0008373 ! sialyltransferase activity

[Term]
id: GO:0003836
name: beta-galactoside (CMP) alpha-2,3-sialyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R." [EC:2.4.99.4]
synonym: "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase activity" EXACT [EC:2.4.99.4]
synonym: "CMP-N-acetylneuraminate:beta-D-galactoside alpha-2,3-N-acetylneuraminyl-transferase activity" EXACT [EC:2.4.99.4]
xref: EC:2.4.99.4
xref: MetaCyc:2.4.99.4-RXN
xref: Reactome:REACT_116038 "ST3GAL1-4 can add a sialic acid to the T antigen at the alpha 3 position, Homo sapiens"
xref: Reactome:REACT_25121 "Addition of alpha-2,3-sialic acid to N-glycan over a galactose by ST3GAL4, Homo sapiens"
xref: RHEA:21619
is_a: GO:0008373 ! sialyltransferase activity

[Term]
id: GO:0003837
name: beta-ureidopropionase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-carbamoyl-beta-alanine + H2O = beta-alanine + CO2 + NH3." [EC:3.5.1.6]
subset: gosubset_prok
synonym: "N-carbamoyl-beta-alanine amidohydrolase activity" EXACT [EC:3.5.1.6]
xref: EC:3.5.1.6
xref: MetaCyc:BETA-UREIDOPROPIONASE-RXN
xref: Reactome:REACT_101423 "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2, Xenopus tropicalis"
xref: Reactome:REACT_102071 "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2, Danio rerio"
xref: Reactome:REACT_102892 "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2, Canis familiaris"
xref: Reactome:REACT_103635 "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2, Taeniopygia guttata"
xref: Reactome:REACT_103759 "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2, Danio rerio"
xref: Reactome:REACT_104624 "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2, Drosophila melanogaster"
xref: Reactome:REACT_104670 "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2, Taeniopygia guttata"
xref: Reactome:REACT_105623 "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2, Gallus gallus"
xref: Reactome:REACT_108466 "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2, Arabidopsis thaliana"
xref: Reactome:REACT_110755 "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2, Dictyostelium discoideum"
xref: Reactome:REACT_112730 "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2, Schizosaccharomyces pombe"
xref: Reactome:REACT_115012 "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2, Schizosaccharomyces pombe"
xref: Reactome:REACT_2183 "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2, Homo sapiens"
xref: Reactome:REACT_28778 "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2, Arabidopsis thaliana"
xref: Reactome:REACT_29340 "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2, Oryza sativa"
xref: Reactome:REACT_34440 "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2, Gallus gallus"
xref: Reactome:REACT_79448 "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2, Xenopus tropicalis"
xref: Reactome:REACT_82451 "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2, Sus scrofa"
xref: Reactome:REACT_84087 "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2, Canis familiaris"
xref: Reactome:REACT_84098 "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2, Mus musculus"
xref: Reactome:REACT_84968 "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2, Bos taurus"
xref: Reactome:REACT_87205 "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2, Drosophila melanogaster"
xref: Reactome:REACT_87574 "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2, Sus scrofa"
xref: Reactome:REACT_87832 "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2, Rattus norvegicus"
xref: Reactome:REACT_902 "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2, Homo sapiens"
xref: Reactome:REACT_90983 "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2, Caenorhabditis elegans"
xref: Reactome:REACT_92584 "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2, Dictyostelium discoideum"
xref: Reactome:REACT_96079 "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2, Bos taurus"
xref: Reactome:REACT_96886 "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2, Mus musculus"
xref: Reactome:REACT_98071 "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2, Oryza sativa"
xref: Reactome:REACT_99446 "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2, Rattus norvegicus"
xref: Reactome:REACT_99655 "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2, Caenorhabditis elegans"
xref: RHEA:11187
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0003838
name: sterol 24-C-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 5-alpha-cholest-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol." [EC:2.1.1.41]
subset: gosubset_prok
synonym: "24-sterol C-methyltransferase activity" EXACT [EC:2.1.1.41]
synonym: "delta(24)-methyltransferase activity" EXACT [EC:2.1.1.41]
synonym: "delta(24)-sterol C-methyltransferase activity" EXACT []
synonym: "delta(24)-sterol methyltransferase activity" EXACT [EC:2.1.1.41]
synonym: "delta24-methyltransferase activity" EXACT [EC:2.1.1.41]
synonym: "delta24-sterol methyltransferase activity" EXACT [EC:2.1.1.41]
synonym: "phytosterol methyltransferase activity" NARROW [EC:2.1.1.41]
synonym: "S-adenosyl-4-methionine:sterol Delta(24)-methyltransferase activity" EXACT [EC:2.1.1.41]
synonym: "S-adenosyl-4-methionine:sterol delta24-methyltransferase activity" EXACT [EC:2.1.1.41]
synonym: "S-adenosyl-L-methionine:Delta(24(23))-sterol methyltransferase activity" EXACT [EC:2.1.1.41]
synonym: "S-adenosyl-L-methionine:Delta24(23)-sterol methyltransferase activity" EXACT [EC:2.1.1.41]
synonym: "S-adenosyl-L-methionine:zymosterol 24-C-methyltransferase activity" EXACT [EC:2.1.1.41]
synonym: "SMT1 activity" NARROW [EC:2.1.1.41]
synonym: "zymosterol-24-methyltransferase activity" NARROW [EC:2.1.1.41]
xref: EC:2.1.1.41
xref: MetaCyc:RXN3O-178
xref: RHEA:21131
is_a: GO:0008169 ! C-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0003839
name: gamma-glutamylcyclotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (5-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid." [EC:2.3.2.4]
synonym: "(5-L-glutamyl)-L-amino-acid 5-glutamyltransferase (cyclizing)" EXACT [EC:2.3.2.4]
synonym: "gamma-glutamyl-amino acid cyclotransferase activity" EXACT [EC:2.3.2.4]
synonym: "gamma-L-glutamylcyclotransferase activity" EXACT [EC:2.3.2.4]
synonym: "L-glutamic cyclase activity" EXACT [EC:2.3.2.4]
xref: EC:2.3.2.4
xref: MetaCyc:GAMMA-GLUTAMYLCYCLOTRANSFERASE-RXN
xref: Reactome:REACT_75867 "5-oxoproline can be formed from gamma-glutamyl-AA products, Homo sapiens"
xref: Reactome:REACT_75929 "Formation of 5-oxoproline from gamma-glutamylcysteine, Homo sapiens"
is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups

[Term]
id: GO:0003840
name: gamma-glutamyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid." [EC:2.3.2.2]
comment: The gene family commonly referred to as gamma-glutamyl transferases (GGT) catalyze hydrolysis of gamma-glutamyl bonds in gamma-glutamyl compounds such as glutathione. In a test tube one can set up conditions in which the enzyme will transfer the gamma-glutamyl portion of the substrate to an acceptor molecule, but this requires non-physiologic conditions, including millmolar concentrations of an acceptor such as glygly. This reaction is used in assays to detect the presence of the enzyme, but is not a physiological function of members of the GGT family (PMC4388159), which should be annotated to a suitable hydrolysis term instead (e.g. glutathione hydrolase activity).
subset: gosubset_prok
synonym: "(5-L-glutamyl)-peptide:amino-acid 5-glutamyltransferase activity" EXACT [EC:2.3.2.2]
synonym: "alpha-glutamyl transpeptidase activity" EXACT [EC:2.3.2.2]
synonym: "gamma-glutamyl peptidyltransferase activity" EXACT [EC:2.3.2.2]
synonym: "gamma-glutamyl transpeptidase activity" EXACT [EC:2.3.2.2]
synonym: "gamma-GPT" RELATED [EC:2.3.2.2]
synonym: "gamma-GT" RELATED [EC:2.3.2.2]
synonym: "gamma-GTP" RELATED [EC:2.3.2.2]
synonym: "glutamyl transpeptidase activity" EXACT [EC:2.3.2.2]
synonym: "L-gamma-glutamyl transpeptidase activity" EXACT [EC:2.3.2.2]
synonym: "L-gamma-glutamyltransferase activity" EXACT [EC:2.3.2.2]
synonym: "L-glutamyltransferase activity" EXACT [EC:2.3.2.2]
xref: EC:2.3.2.2
xref: KEGG:R04159
xref: MetaCyc:GAMMA-GLUTAMYLTRANSFERASE-RXN
xref: Reactome:REACT_105103 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Taeniopygia guttata"
xref: Reactome:REACT_107509 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Xenopus tropicalis"
xref: Reactome:REACT_108503 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Escherichia coli"
xref: Reactome:REACT_109920 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Oryza sativa"
xref: Reactome:REACT_114722 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Caenorhabditis elegans"
xref: Reactome:REACT_15356 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Homo sapiens"
xref: Reactome:REACT_28900 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Saccharomyces cerevisiae"
xref: Reactome:REACT_29202 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Bos taurus"
xref: Reactome:REACT_75920 "Glutathione is hydrolyzed, Homo sapiens"
xref: Reactome:REACT_79594 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Danio rerio"
xref: Reactome:REACT_80649 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Sus scrofa"
xref: Reactome:REACT_82062 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Arabidopsis thaliana"
xref: Reactome:REACT_85164 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Schizosaccharomyces pombe"
xref: Reactome:REACT_92059 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Canis familiaris"
xref: Reactome:REACT_97168 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Mus musculus"
xref: Reactome:REACT_99498 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Gallus gallus"
is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups

[Term]
id: GO:0003841
name: 1-acylglycerol-3-phosphate O-acyltransferase activity
namespace: molecular_function
alt_id: GO:0004469
def: "Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate." [EC:2.3.1.51, GOC:ab]
subset: gosubset_prok
synonym: "1-acyl-sn-glycero-3-phosphate acyltransferase activity" EXACT [EC:2.3.1.51]
synonym: "1-acyl-sn-glycerol 3-phosphate acyltransferase activity" EXACT [EC:2.3.1.51]
synonym: "1-acyl-sn-glycerol-3-phosphate acyltransferase activity" EXACT []
synonym: "1-acylglycero-3-phosphate acyltransferase activity" EXACT [EC:2.3.1.51]
synonym: "1-acylglycerolphosphate acyltransferase activity" EXACT [EC:2.3.1.51]
synonym: "1-acylglycerophosphate acyltransferase activity" EXACT [EC:2.3.1.51]
synonym: "acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase activity" EXACT [EC:2.3.1.51]
synonym: "lysophosphatidate acyltransferase activity" EXACT []
synonym: "lysophosphatidic acid-acyltransferase activity" RELATED [EC:2.3.1.51]
xref: EC:2.3.1.51
xref: MetaCyc:RXN-1623
xref: Reactome:REACT_100569 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Drosophila melanogaster"
xref: Reactome:REACT_101159 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Bos taurus"
xref: Reactome:REACT_104719 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Oryza sativa"
xref: Reactome:REACT_108799 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Canis familiaris"
xref: Reactome:REACT_109082 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Xenopus tropicalis"
xref: Reactome:REACT_113184 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Dictyostelium discoideum"
xref: Reactome:REACT_113260 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Arabidopsis thaliana"
xref: Reactome:REACT_115377 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Caenorhabditis elegans"
xref: Reactome:REACT_2042 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Homo sapiens"
xref: Reactome:REACT_30683 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Gallus gallus"
xref: Reactome:REACT_32891 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Sus scrofa"
xref: Reactome:REACT_79417 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Danio rerio"
xref: Reactome:REACT_81957 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Mus musculus"
xref: Reactome:REACT_84904 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Taeniopygia guttata"
xref: Reactome:REACT_93954 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Rattus norvegicus"
xref: Reactome:REACT_93992 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Escherichia coli"
xref: Reactome:REACT_96723 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Schizosaccharomyces pombe"
xref: Reactome:REACT_97949 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Saccharomyces cerevisiae"
xref: Reactome:REACT_99430 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Mycobacterium tuberculosis"
xref: RHEA:19712
is_a: GO:0016411 ! acylglycerol O-acyltransferase activity
is_a: GO:0042171 ! lysophosphatidic acid acyltransferase activity

[Term]
id: GO:0003842
name: 1-pyrroline-5-carboxylate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-pyrroline-5-carboxylate + NAD+ + H2O = L-glutamate + NADH + H(+)." [EC:1.5.1.12]
subset: gosubset_prok
synonym: "1-pyrroline dehydrogenase" BROAD [EC:1.5.1.12]
synonym: "1-pyrroline-5-carboxylate:NAD+ oxidoreductase activity" EXACT [EC:1.5.1.12]
synonym: "delta1-pyrroline-5-carboxylate dehydrogenase activity" EXACT [EC:1.5.1.12]
synonym: "L-pyrroline-5-carboxylate-NAD+ oxidoreductase activity" EXACT [EC:1.5.1.12]
synonym: "pyrroline-5-carboxylate dehydrogenase activity" EXACT [EC:1.5.1.12]
synonym: "pyrroline-5-carboxylic acid dehydrogenase activity" EXACT [EC:1.5.1.12]
xref: EC:1.5.1.12
xref: MetaCyc:PYRROLINECARBDEHYDROG-RXN
xref: Reactome:REACT_101154 "L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+, Gallus gallus"
xref: Reactome:REACT_2180 "L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+, Homo sapiens"
xref: Reactome:REACT_28267 "L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+, Bos taurus"
xref: Reactome:REACT_29350 "L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+, Taeniopygia guttata"
xref: Reactome:REACT_30746 "L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+, Dictyostelium discoideum"
xref: Reactome:REACT_32976 "L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+, Mus musculus"
xref: Reactome:REACT_33427 "L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+, Rattus norvegicus"
xref: Reactome:REACT_77246 "L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+, Caenorhabditis elegans"
xref: Reactome:REACT_78368 "L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+, Staphylococcus aureus N315"
xref: Reactome:REACT_79652 "L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+, Mycobacterium tuberculosis"
xref: Reactome:REACT_82290 "L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+, Drosophila melanogaster"
xref: Reactome:REACT_83335 "L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+, Escherichia coli"
xref: Reactome:REACT_84624 "L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+, Xenopus tropicalis"
xref: Reactome:REACT_88645 "L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+, Danio rerio"
xref: Reactome:REACT_91287 "L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+, Saccharomyces cerevisiae"
xref: Reactome:REACT_94154 "L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+, Canis familiaris"
xref: Reactome:REACT_97859 "L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+, Schizosaccharomyces pombe"
xref: RHEA:16420
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0003843
name: 1,3-beta-D-glucan synthase activity
namespace: molecular_function
alt_id: GO:0009981
def: "Catalysis of the reaction: UDP-glucose + [(1->3)-beta-D-glucosyl](n) = UDP + [(1->3)-beta-D-glucosyl](n+1)." [EC:2.4.1.34]
synonym: "(1,3)-beta-glucan (callose) synthase activity" EXACT [EC:2.4.1.34]
synonym: "1,3-beta-D-glucan synthetase activity" EXACT [EC:2.4.1.34]
synonym: "1,3-beta-D-glucan-UDP glucosyltransferase activity" EXACT [EC:2.4.1.34]
synonym: "1,3-beta-glucan synthase activity" EXACT [EC:2.4.1.34]
synonym: "1,3-beta-glucan-uridine diphosphoglucosyltransferase activity" EXACT [EC:2.4.1.34]
synonym: "beta-1,3-glucan synthase activity" EXACT []
synonym: "beta-1,3-glucan synthetase activity" EXACT [EC:2.4.1.34]
synonym: "callose synthase activity" EXACT []
synonym: "callose synthetase activity" EXACT [EC:2.4.1.34]
synonym: "GS-II" RELATED [EC:2.4.1.34]
synonym: "paramylon synthetase" RELATED [EC:2.4.1.34]
synonym: "UDP-glucose-1,3-beta-D-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34]
synonym: "UDP-glucose-1,3-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34]
synonym: "UDP-glucose-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34]
synonym: "UDP-glucose:(1,3)beta-glucan synthase activity" EXACT [EC:2.4.1.34]
synonym: "UDP-glucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.34]
synonym: "UDPglucose-1,3-beta-D-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34]
synonym: "UDPglucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.34]
synonym: "uridine diphosphoglucose-1,3-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34]
xref: EC:2.4.1.34
xref: MetaCyc:13-BETA-GLUCAN-SYNTHASE-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0003844
name: 1,4-alpha-glucan branching enzyme activity
namespace: molecular_function
def: "Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxyl group in a similar glucan chain." [EC:2.4.1.18]
subset: gosubset_prok
synonym: "1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-alpha-D-(1,4-alpha-D-glucano)-transferase activity" EXACT []
synonym: "1,4-glucan-6-(1,4-glucano)-transferase activity" EXACT []
synonym: "alpha-1,4-glucan:alpha-1,4-glucan-6-glycosyltransferase activity" EXACT [EC:2.4.1.18]
synonym: "alpha-glucan-branching glycosyltransferase activity" EXACT [EC:2.4.1.18]
synonym: "amylo-(1,4 to 1,6)transglucosidase activity" EXACT [EC:2.4.1.18]
synonym: "amylo-(1,4->1,6)-transglycosylase activity" EXACT [EC:2.4.1.18]
synonym: "amylose isomerase activity" EXACT [EC:2.4.1.18]
synonym: "branching enzyme activity" RELATED [EC:2.4.1.18]
synonym: "branching glycosyltransferase activity" EXACT [EC:2.4.1.18]
synonym: "enzymatic branching factor" RELATED [EC:2.4.1.18]
synonym: "enzyme Q" RELATED [EC:2.4.1.18]
synonym: "glucosan transglycosylase activity" EXACT [EC:2.4.1.18]
synonym: "glycogen branching enzyme activity" EXACT [EC:2.4.1.18]
synonym: "plant branching enzyme" RELATED [EC:2.4.1.18]
synonym: "Q-enzyme" RELATED [EC:2.4.1.18]
synonym: "starch branching enzyme" RELATED [EC:2.4.1.18]
xref: EC:2.4.1.18
xref: MetaCyc:GLYCOGEN-BRANCH-RXN
xref: Reactome:REACT_105148 "poly((1,4)-alpha-D-glucosyl) glycogenin => glycogen-glycogenin, Danio rerio"
xref: Reactome:REACT_106694 "poly((1,4)-alpha-D-glucosyl) glycogenin => glycogen-glycogenin, Caenorhabditis elegans"
xref: Reactome:REACT_107726 "poly((1,4)-alpha-D-glucosyl) glycogenin => glycogen-glycogenin, Saccharomyces cerevisiae"
xref: Reactome:REACT_115406 "poly((1,4)-alpha-D-glucosyl) glycogenin => glycogen-glycogenin, Arabidopsis thaliana"
xref: Reactome:REACT_1560 "poly((1,4)-alpha-D-glucosyl) glycogenin => glycogen-glycogenin, Homo sapiens"
xref: Reactome:REACT_30904 "poly((1,4)-alpha-D-glucosyl) glycogenin => glycogen-glycogenin, Bos taurus"
xref: Reactome:REACT_32069 "poly((1,4)-alpha-D-glucosyl) glycogenin => glycogen-glycogenin, Taeniopygia guttata"
xref: Reactome:REACT_34100 "poly((1,4)-alpha-D-glucosyl) glycogenin => glycogen-glycogenin, Canis familiaris"
xref: Reactome:REACT_86636 "poly((1,4)-alpha-D-glucosyl) glycogenin => glycogen-glycogenin, Xenopus tropicalis"
xref: Reactome:REACT_89477 "poly((1,4)-alpha-D-glucosyl) glycogenin => glycogen-glycogenin, Mus musculus"
xref: Reactome:REACT_89641 "poly((1,4)-alpha-D-glucosyl) glycogenin => glycogen-glycogenin, Gallus gallus"
xref: Reactome:REACT_94260 "poly((1,4)-alpha-D-glucosyl) glycogenin => glycogen-glycogenin, Rattus norvegicus"
xref: Reactome:REACT_94674 "poly((1,4)-alpha-D-glucosyl) glycogenin => glycogen-glycogenin, Oryza sativa"
xref: Reactome:REACT_96621 "poly((1,4)-alpha-D-glucosyl) glycogenin => glycogen-glycogenin, Sus scrofa"
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0003845
name: 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity
namespace: molecular_function
def: "Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD(P)+ = an 11-oxosteroid + NAD(P)H + H(+)." [EC:1.1.1.146, PMID:15761036]
subset: gosubset_prok
synonym: "11beta-hydroxy steroid dehydrogenase" EXACT [EC:1.1.1.146]
synonym: "11beta-hydroxysteroid dehydrogenase" EXACT [EC:1.1.1.146]
synonym: "beta-hydroxysteroid dehydrogenase" BROAD [EC:1.1.1.146]
synonym: "corticosteroid 11-reductase" RELATED [EC:1.1.1.146]
synonym: "corticosteroid 11beta-dehydrogenase" RELATED [EC:1.1.1.146]
synonym: "dehydrogenase, 11beta-hydroxy steroid" EXACT [EC:1.1.1.146]
xref: MetaCyc:11-BETA-HYDROXYSTEROID-DEHYDROGENASE-RXN
xref: Reactome:REACT_10043 "Oxidation of cortisol to yield cortisone, Homo sapiens"
xref: Reactome:REACT_102267 "Oxidation of cortisol to yield cortisone, Canis familiaris"
xref: Reactome:REACT_114165 "Oxidation of cortisol to yield cortisone, Plasmodium falciparum"
xref: Reactome:REACT_31438 "Oxidation of cortisol to yield cortisone, Mus musculus"
xref: Reactome:REACT_32859 "Oxidation of cortisol to yield cortisone, Dictyostelium discoideum"
xref: Reactome:REACT_82916 "Oxidation of cortisol to yield cortisone, Oryza sativa"
xref: Reactome:REACT_84167 "Oxidation of cortisol to yield cortisone, Xenopus tropicalis"
xref: Reactome:REACT_84288 "Oxidation of cortisol to yield cortisone, Sus scrofa"
xref: Reactome:REACT_86323 "Oxidation of cortisol to yield cortisone, Bos taurus"
xref: Reactome:REACT_86610 "Oxidation of cortisol to yield cortisone, Arabidopsis thaliana"
xref: Reactome:REACT_93487 "Oxidation of cortisol to yield cortisone, Gallus gallus"
xref: Reactome:REACT_95677 "Oxidation of cortisol to yield cortisone, Taeniopygia guttata"
xref: Wikipedia:11beta-hydroxysteroid_dehydrogenase
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0003846
name: 2-acylglycerol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + 2-acylglycerol = CoA + diacylglycerol." [EC:2.3.1.22]
synonym: "acyl coenzyme A-monoglyceride acyltransferase activity" EXACT [EC:2.3.1.22]
synonym: "acyl-CoA:2-acylglycerol O-acyltransferase activity" EXACT [EC:2.3.1.22]
synonym: "acylglycerol palmitoyltransferase activity" EXACT [EC:2.3.1.22]
synonym: "monoacylglycerol acyltransferase activity" EXACT [EC:2.3.1.22]
synonym: "monoglyceride acyltransferase activity" EXACT [EC:2.3.1.22]
xref: EC:2.3.1.22
xref: MetaCyc:2-ACYLGLYCEROL-O-ACYLTRANSFERASE-RXN
xref: RHEA:16744
is_a: GO:0016411 ! acylglycerol O-acyltransferase activity

[Term]
id: GO:0003847
name: 1-alkyl-2-acetylglycerophosphocholine esterase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate." [EC:3.1.1.47]
subset: goslim_chembl
subset: gosubset_prok
synonym: "1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase activity" EXACT [EC:3.1.1.47]
synonym: "1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetylhydrolase activity" EXACT [EC:3.1.1.47]
synonym: "2-acetyl-1-alkylglycerophosphocholine esterase activity" EXACT []
synonym: "alkylacetyl-GPC:acetylhydrolase activity" EXACT [EC:3.1.1.47]
synonym: "LDL-associated phospholipase A(2) activity" RELATED [EC:3.1.1.47]
synonym: "LDL-associated phospholipase A2" RELATED [EC:3.1.1.47]
synonym: "LDL-PLA(2) activity" RELATED [EC:3.1.1.47]
synonym: "LDL-PLA2" RELATED [EC:3.1.1.47]
synonym: "PAF 2-acylhydrolase activity" RELATED [EC:3.1.1.47]
synonym: "PAF acetylhydrolase activity" RELATED [EC:3.1.1.47]
synonym: "platelet-activating factor acetylhydrolase activity" RELATED [EC:3.1.1.47]
xref: EC:3.1.1.47
xref: MetaCyc:3.1.1.47-RXN
xref: RHEA:17780
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0003848
name: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + ATP = (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + AMP + 2 H(+)." [EC:2.7.6.3, RHEA:11415]
subset: goslim_chembl
subset: gosubset_prok
synonym: "2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase activity" EXACT []
synonym: "6-hydroxymethyl-7,8-dihydropterin diphosphokinase activity" EXACT [EC:2.7.6.3]
synonym: "6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase activity" EXACT [EC:2.7.6.3]
synonym: "7,8-dihydro-6-hydroxymethylpterin diphosphokinase activity" EXACT [EC:2.7.6.3]
synonym: "7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase activity" EXACT [EC:2.7.6.3]
synonym: "7,8-dihydroxymethylpterin-pyrophosphokinase activity" EXACT [EC:2.7.6.3]
synonym: "ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 6'-diphosphotransferase activity" EXACT [EC:2.7.6.3]
synonym: "H2-pteridine-CH2OH pyrophosphokinase activity" EXACT [EC:2.7.6.3]
synonym: "HPPK" RELATED [EC:2.7.6.3]
synonym: "hydroxymethyldihydropteridine pyrophosphokinase activity" EXACT [EC:2.7.6.3]
xref: EC:2.7.6.3
xref: KEGG:R03503
xref: MetaCyc:H2PTERIDINEPYROPHOSPHOKIN-RXN
xref: RHEA:11415
is_a: GO:0016778 ! diphosphotransferase activity

[Term]
id: GO:0003849
name: 3-deoxy-7-phosphoheptulonate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-erythrose 4-phosphate + H(2)O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate." [EC:2.5.1.54, RHEA:14720]
comment: Note that this function was formerly EC:4.1.2.15.
subset: gosubset_prok
synonym: "2-dehydro-3-deoxy-phosphoheptonate aldolase activity" EXACT [EC:2.5.1.54]
synonym: "2-dehydro-3-deoxyphosphoheptonate aldolase activity" EXACT []
synonym: "2-keto-3-deoxy-D-arabino-heptonic acid 7-phosphate synthetase activity" EXACT [EC:2.5.1.54]
synonym: "3-deoxy-D-arabino-2-heptulosonic acid 7-phosphate synthetase activity" EXACT [EC:2.5.1.54]
synonym: "3-deoxy-D-arabino-heptolosonate-7-phosphate synthetase activity" EXACT [EC:2.5.1.54]
synonym: "3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase activity" EXACT [EC:2.5.1.54]
synonym: "7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate" RELATED [EC:2.5.1.54]
synonym: "7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating) activity" EXACT [EC:2.5.1.54]
synonym: "7-phospho-2-keto-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating) activity" EXACT [EC:2.5.1.54]
synonym: "D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating) activity" EXACT [EC:2.5.1.54]
synonym: "D-erythrose-4-phosphate-lyase activity" RELATED [EC:2.5.1.54]
synonym: "DAH7-P synthase activity" EXACT [EC:2.5.1.54]
synonym: "DAHP synthase activity" EXACT [EC:2.5.1.54]
synonym: "deoxy-D-arabino-heptulosonate-7-phosphate synthetase activity" EXACT [EC:2.5.1.54]
synonym: "DHAP synthase activity" EXACT [EC:2.5.1.54]
synonym: "DS-Co activity" RELATED [EC:2.5.1.54]
synonym: "DS-Mn activity" RELATED [EC:2.5.1.54]
synonym: "KDPH synthase activity" EXACT [EC:2.5.1.54]
synonym: "KDPH synthetase activity" EXACT [EC:2.5.1.54]
synonym: "phospho-2-dehydro-3-deoxyheptonate aldolase activity" EXACT [EC:2.5.1.54]
synonym: "phospho-2-keto-3-deoxyheptanoate aldolase activity" EXACT [EC:2.5.1.54]
synonym: "phospho-2-keto-3-deoxyheptonate aldolase activity" EXACT [EC:2.5.1.54]
synonym: "phospho-2-keto-3-deoxyheptonic aldolase activity" EXACT [EC:2.5.1.54]
synonym: "phospho-2-oxo-3-deoxyheptonate aldolase activity" EXACT [EC:2.5.1.54]
synonym: "phosphoenolpyruvate:D-erythrose-4-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)" EXACT [EC:2.5.1.54]
xref: EC:2.5.1.54
xref: KEGG:R01826
xref: MetaCyc:DAHPSYN-RXN
xref: Reactome:REACT_27267 "DHAP from Ery4P and PEP, Mycobacterium tuberculosis"
xref: RHEA:14720
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0003850
name: 2-deoxyglucose-6-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-deoxy-D-glucose-6-phosphate + H2O = 2-deoxy-D-glucose + phosphate." [EC:3.1.3.68]
synonym: "2-deoxy-D-glucose-6-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.68]
synonym: "2-deoxyglucose-6-phosphate phosphatase activity" EXACT [EC:3.1.3.68]
xref: EC:3.1.3.68
xref: KEGG:R02587
xref: MetaCyc:3.1.3.68-RXN
xref: RHEA:22239
is_a: GO:0050308 ! sugar-phosphatase activity

[Term]
id: GO:0003851
name: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-galactose + 2-(2-hydroxyacyl)sphingosine = UDP + 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine." [EC:2.4.1.45]
synonym: "cerebroside synthase activity" EXACT [EC:2.4.1.45]
synonym: "UDP-galactose-ceramide galactosyltransferase activity" EXACT [EC:2.4.1.45]
synonym: "UDP-galactose:2-(2-hydroxyacyl)sphingosine 1-beta-D-galactosyl-transferase activity" EXACT [EC:2.4.1.45]
synonym: "UDPgalactose-2-hydroxyacylsphingosine galactosyltransferase activity" EXACT [EC:2.4.1.45]
synonym: "UDPgalactose:2-(2-hydroxyacyl)sphingosine 1-beta-D-galactosyl-transferase activity" EXACT [EC:2.4.1.45]
synonym: "UDPgalactose:2-2-hydroxyacylsphingosine galactosyltransferase activity" EXACT [EC:2.4.1.45]
synonym: "UDPgalactose:ceramide galactosyltransferase activity" EXACT [EC:2.4.1.45]
synonym: "uridine diphosphogalactose-2-hydroxyacylsphingosine galactosyltransferase activity" EXACT [EC:2.4.1.45]
xref: EC:2.4.1.45
xref: MetaCyc:2.4.1.45-RXN
xref: RHEA:10859
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0003852
name: 2-isopropylmalate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-methyl-2-oxobutanoate + acetyl-CoA + H(2)O = (2S)-2-isopropylmalate + CoA + H(+)." [EC:2.3.3.13, RHEA:21527]
comment: Note that this function was formerly EC:4.1.3.12.
subset: gosubset_prok
synonym: "3-carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating) activity" EXACT [EC:2.3.3.13]
synonym: "acetyl-CoA:3-methyl-2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)" EXACT [EC:2.3.3.13]
synonym: "alpha-IPM synthetase activity" EXACT [EC:2.3.3.13]
synonym: "alpha-isopropylmalate synthase activity" EXACT [EC:2.3.3.13]
synonym: "alpha-isopropylmalate synthetase activity" EXACT [EC:2.3.3.13]
synonym: "alpha-isopropylmalic synthetase activity" EXACT [EC:2.3.3.13]
synonym: "isopropylmalate synthase activity" EXACT [EC:2.3.3.13]
synonym: "isopropylmalate synthetase activity" EXACT [EC:2.3.3.13]
xref: EC:2.3.3.13
xref: KEGG:R01213
xref: MetaCyc:2-ISOPROPYLMALATESYN-RXN
xref: RHEA:21527
is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

[Term]
id: GO:0003853
name: 2-methylacyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-methylbutanoyl-CoA + acceptor = 2-methylbut-2-enoyl-CoA + reduced acceptor." [EC:1.3.99.12]
synonym: "2-methyl branched chain acyl-CoA dehydrogenase activity" EXACT [EC:1.3.99.12]
synonym: "2-methylbutanoyl-CoA:(acceptor) oxidoreductase activity" EXACT [EC:1.3.99.12]
synonym: "2-methylbutanoyl-CoA:acceptor oxidoreductase activity" EXACT [EC:1.3.99.12]
synonym: "branched-chain acyl-CoA dehydrogenase activity" RELATED [EC:1.3.99.12]
xref: EC:1.3.99.12
xref: MetaCyc:2-METHYLACYL-COA-DEHYDROGENASE-RXN
xref: RHEA:13264
is_a: GO:0003995 ! acyl-CoA dehydrogenase activity

[Term]
id: GO:0003854
name: 3-beta-hydroxy-delta5-steroid dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 3-beta-hydroxy-delta(5)-steroid + NAD+ = a 3-oxo-delta(5)-steroid + NADH + H(+)." [EC:1.1.1.145]
subset: gosubset_prok
synonym: "3-beta-hydroxy-5-ene steroid dehydrogenase activity" EXACT [EC:1.1.1.145]
synonym: "3-beta-hydroxy-D5-steroid dehydrogenase activity" EXACT []
synonym: "3beta-HSDH" RELATED [EC:1.1.1.145]
synonym: "3beta-hydroxy steroid dehydrogenase/isomerase activity" EXACT [EC:1.1.1.145]
synonym: "3beta-hydroxy-5-ene steroid dehydrogenase activity" EXACT [EC:1.1.1.145]
synonym: "3beta-hydroxy-5-ene-steroid dehydrogenase activity" EXACT [EC:1.1.1.145]
synonym: "3beta-hydroxy-5-ene-steroid oxidoreductase activity" EXACT [EC:1.1.1.145]
synonym: "3beta-hydroxy-delta5-C27-steroid dehydrogenase/isomerase activity" EXACT [EC:1.1.1.145]
synonym: "3beta-hydroxy-delta5-C27-steroid oxidoreductase" BROAD [EC:1.1.1.145]
synonym: "3beta-hydroxy-delta5-steroid dehydrogenase activity" EXACT [EC:1.1.1.145]
synonym: "3beta-hydroxy-delta5-steroid:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.145]
synonym: "5-ene-3-beta-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.145]
synonym: "delta5-3beta-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.145]
synonym: "progesterone reductase activity" BROAD [EC:1.1.1.145]
synonym: "steroid-delta5-3beta-ol dehydrogenase activity" EXACT [EC:1.1.1.145]
xref: EC:1.1.1.145
xref: MetaCyc:1.1.1.145-RXN
xref: Reactome:REACT_10031 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Homo sapiens"
xref: Reactome:REACT_10067 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Homo sapiens"
xref: Reactome:REACT_100839 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Danio rerio"
xref: Reactome:REACT_10090 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Homo sapiens"
xref: Reactome:REACT_10115 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Homo sapiens"
xref: Reactome:REACT_101983 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Bos taurus"
xref: Reactome:REACT_103390 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Bos taurus"
xref: Reactome:REACT_103657 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Sus scrofa"
xref: Reactome:REACT_103990 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Danio rerio"
xref: Reactome:REACT_104422 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Drosophila melanogaster"
xref: Reactome:REACT_104615 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Gallus gallus"
xref: Reactome:REACT_105565 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Mus musculus"
xref: Reactome:REACT_106120 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Bos taurus"
xref: Reactome:REACT_106214 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Danio rerio"
xref: Reactome:REACT_106644 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Taeniopygia guttata"
xref: Reactome:REACT_108035 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Canis familiaris"
xref: Reactome:REACT_108087 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Xenopus tropicalis"
xref: Reactome:REACT_108432 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Xenopus tropicalis"
xref: Reactome:REACT_109510 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Mus musculus"
xref: Reactome:REACT_111989 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Mycobacterium tuberculosis"
xref: Reactome:REACT_112248 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Escherichia coli"
xref: Reactome:REACT_113096 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Mycobacterium tuberculosis"
xref: Reactome:REACT_113257 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Escherichia coli"
xref: Reactome:REACT_113772 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Escherichia coli"
xref: Reactome:REACT_114424 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Escherichia coli"
xref: Reactome:REACT_114777 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Mycobacterium tuberculosis"
xref: Reactome:REACT_114921 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Mycobacterium tuberculosis"
xref: Reactome:REACT_115275 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Escherichia coli"
xref: Reactome:REACT_115303 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Mycobacterium tuberculosis"
xref: Reactome:REACT_28427 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Danio rerio"
xref: Reactome:REACT_28467 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Drosophila melanogaster"
xref: Reactome:REACT_29450 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Danio rerio"
xref: Reactome:REACT_30525 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Taeniopygia guttata"
xref: Reactome:REACT_30795 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Rattus norvegicus"
xref: Reactome:REACT_30899 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Canis familiaris"
xref: Reactome:REACT_32283 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Gallus gallus"
xref: Reactome:REACT_32783 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Mus musculus"
xref: Reactome:REACT_32924 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Gallus gallus"
xref: Reactome:REACT_33199 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Sus scrofa"
xref: Reactome:REACT_33352 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Gallus gallus"
xref: Reactome:REACT_34556 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Rattus norvegicus"
xref: Reactome:REACT_77900 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Drosophila melanogaster"
xref: Reactome:REACT_78893 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Xenopus tropicalis"
xref: Reactome:REACT_79104 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Sus scrofa"
xref: Reactome:REACT_79525 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Rattus norvegicus"
xref: Reactome:REACT_79553 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Bos taurus"
xref: Reactome:REACT_80359 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Drosophila melanogaster"
xref: Reactome:REACT_80746 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Rattus norvegicus"
xref: Reactome:REACT_81646 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Taeniopygia guttata"
xref: Reactome:REACT_82293 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Sus scrofa"
xref: Reactome:REACT_82688 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Mus musculus"
xref: Reactome:REACT_84251 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Canis familiaris"
xref: Reactome:REACT_85738 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Canis familiaris"
xref: Reactome:REACT_86717 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Drosophila melanogaster"
xref: Reactome:REACT_87612 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Taeniopygia guttata"
xref: Reactome:REACT_88118 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Mus musculus"
xref: Reactome:REACT_88292 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Rattus norvegicus"
xref: Reactome:REACT_88643 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Xenopus tropicalis"
xref: Reactome:REACT_91120 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Gallus gallus"
xref: Reactome:REACT_93787 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Taeniopygia guttata"
xref: Reactome:REACT_94450 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Xenopus tropicalis"
xref: Reactome:REACT_96507 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Sus scrofa"
xref: Reactome:REACT_99573 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Canis familiaris"
xref: Reactome:REACT_99689 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Bos taurus"
xref: Reactome:REACT_9989 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Homo sapiens"
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0003855
name: 3-dehydroquinate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-dehydroquinate = 3-dehydroshikimate + H(2)O." [EC:4.2.1.10, RHEA:21099]
subset: gosubset_prok
synonym: "3-dehydroquinase activity" EXACT [EC:4.2.1.10]
synonym: "3-dehydroquinate hydro-lyase (3-dehydroshikimate-forming)" EXACT [EC:4.2.1.10]
synonym: "3-dehydroquinate hydro-lyase activity" EXACT [EC:4.2.1.10]
synonym: "3-dehydroquinate hydrolase activity" EXACT [EC:4.2.1.10]
synonym: "5-dehydroquinase activity" EXACT [EC:4.2.1.10]
synonym: "5-dehydroquinate dehydratase activity" EXACT [EC:4.2.1.10]
synonym: "5-dehydroquinate hydro-lyase activity" EXACT [EC:4.2.1.10]
synonym: "dehydroquinase activity" EXACT [EC:4.2.1.10]
synonym: "dehydroquinate dehydratase activity" EXACT [EC:4.2.1.10]
synonym: "DHQase" EXACT [EC:4.2.1.10]
xref: EC:4.2.1.10
xref: KEGG:R03084
xref: MetaCyc:3-DEHYDROQUINATE-DEHYDRATASE-RXN
xref: Reactome:REACT_27221 "Dehydratation of DHQ yields DHS, Mycobacterium tuberculosis"
xref: RHEA:21099
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0003856
name: 3-dehydroquinate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate." [EC:4.2.3.4, RHEA:21971]
subset: gosubset_prok
synonym: "3-dehydroquinate synthetase activity" EXACT [EC:4.2.3.4]
synonym: "3-deoxy-arabino-heptulonate-7-phosphate phosphate-lyase (cyclizing)" EXACT [EC:4.2.3.4]
synonym: "3-deoxy-arabino-heptulonate-7-phosphate phosphate-lyase (cyclizing; 3-dehydroquinate-forming)" EXACT [EC:4.2.3.4]
synonym: "3-deoxy-arabino-heptulosonate-7-phosphate phosphate-lyase (cyclizing)" EXACT [EC:4.2.3.4]
synonym: "5-dehydroquinate synthase activity" EXACT [EC:4.2.3.4]
synonym: "5-dehydroquinic acid synthetase activity" EXACT [EC:4.2.3.4]
synonym: "dehydroquinate synthase activity" EXACT [EC:4.2.3.4]
synonym: "DHQ synthase" EXACT [PMID:17586643]
synonym: "DHQS" EXACT [PMID:17586643]
xref: EC:4.2.3.4
xref: KEGG:R03083
xref: MetaCyc:3-DEHYDROQUINATE-SYNTHASE-RXN
xref: Reactome:REACT_27251 "DHQ from DAHP dephosphorylation, Mycobacterium tuberculosis"
xref: RHEA:21971
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0003857
name: 3-hydroxyacyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H(+)." [EC:1.1.1.35]
comment: See also 'long-chain-3-hydroxyacyl-CoA dehydrogenase activity ; GO:0016509'.
subset: gosubset_prok
synonym: "3-oxoacyl-thioester reductase activity" RELATED [PMID:19685079]
synonym: "beta-hydroxyacyl dehydrogenase activity" EXACT [EC:1.1.1.35]
synonym: "beta-hydroxyacyl-coenzyme A synthetase activity" EXACT [EC:1.1.1.35]
synonym: "beta-hydroxyacylcoenzyme A dehydrogenase activity" EXACT [EC:1.1.1.35]
synonym: "beta-hydroxybutyrylcoenzyme A dehydrogenase activity" NARROW [EC:1.1.1.35]
synonym: "beta-keto-reductase activity" EXACT [EC:1.1.1.35]
synonym: "beta-ketoacyl-CoA reductase" BROAD [EC:1.1.1.35]
synonym: "L-3-hydroxyacyl CoA dehydrogenase activity" EXACT [EC:1.1.1.35]
synonym: "L-3-hydroxyacyl coenzyme A dehydrogenase activity" EXACT [EC:1.1.1.35]
xref: EC:1.1.1.35
xref: MetaCyc:OHACYL-COA-DEHYDROG-RXN
xref: Reactome:REACT_100238 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H, Danio rerio"
xref: Reactome:REACT_100408 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA, Caenorhabditis elegans"
xref: Reactome:REACT_100617 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+, Xenopus tropicalis"
xref: Reactome:REACT_10065 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA, Homo sapiens"
xref: Reactome:REACT_101468 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H, Caenorhabditis elegans"
xref: Reactome:REACT_101506 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA, Xenopus tropicalis"
xref: Reactome:REACT_101519 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H, Canis familiaris"
xref: Reactome:REACT_101647 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H, Danio rerio"
xref: Reactome:REACT_101913 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+, Gallus gallus"
xref: Reactome:REACT_101921 "3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+, Dictyostelium discoideum"
xref: Reactome:REACT_102671 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H, Gallus gallus"
xref: Reactome:REACT_102910 "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+, Dictyostelium discoideum"
xref: Reactome:REACT_102920 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H, Caenorhabditis elegans"
xref: Reactome:REACT_103002 "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+, Caenorhabditis elegans"
xref: Reactome:REACT_103054 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H, Bos taurus"
xref: Reactome:REACT_103256 "3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+, Rattus norvegicus"
xref: Reactome:REACT_103362 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H, Oryza sativa"
xref: Reactome:REACT_103856 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H, Sus scrofa"
xref: Reactome:REACT_104004 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+, Caenorhabditis elegans"
xref: Reactome:REACT_104064 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H, Bos taurus"
xref: Reactome:REACT_104792 "3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+, Saccharomyces cerevisiae"
xref: Reactome:REACT_105101 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA, Arabidopsis thaliana"
xref: Reactome:REACT_105286 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H, Escherichia coli"
xref: Reactome:REACT_105300 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Sus scrofa"
xref: Reactome:REACT_106598 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA, Caenorhabditis elegans"
xref: Reactome:REACT_106630 "3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+, Caenorhabditis elegans"
xref: Reactome:REACT_106706 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H, Mycobacterium tuberculosis"
xref: Reactome:REACT_106767 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA, Canis familiaris"
xref: Reactome:REACT_106920 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+, Taeniopygia guttata"
xref: Reactome:REACT_106947 "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H, Mus musculus"
xref: Reactome:REACT_106969 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H, Gallus gallus"
xref: Reactome:REACT_106993 "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H, Drosophila melanogaster"
xref: Reactome:REACT_107615 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Danio rerio"
xref: Reactome:REACT_107618 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H, Xenopus tropicalis"
xref: Reactome:REACT_107700 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H, Gallus gallus"
xref: Reactome:REACT_107858 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H, Escherichia coli"
xref: Reactome:REACT_107953 "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H, Sus scrofa"
xref: Reactome:REACT_107981 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H, Canis familiaris"
xref: Reactome:REACT_108093 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H, Escherichia coli"
xref: Reactome:REACT_108518 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H, Dictyostelium discoideum"
xref: Reactome:REACT_108521 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H, Dictyostelium discoideum"
xref: Reactome:REACT_109194 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H, Xenopus tropicalis"
xref: Reactome:REACT_109636 "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H, Taeniopygia guttata"
xref: Reactome:REACT_109679 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA, Rattus norvegicus"
xref: Reactome:REACT_109823 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H, Mycobacterium tuberculosis"
xref: Reactome:REACT_109984 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+, Arabidopsis thaliana"
xref: Reactome:REACT_110388 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H, Danio rerio"
xref: Reactome:REACT_110947 "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H, Caenorhabditis elegans"
xref: Reactome:REACT_112490 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H, Staphylococcus aureus N315"
xref: Reactome:REACT_113301 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H, Staphylococcus aureus N315"
xref: Reactome:REACT_113705 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H, Staphylococcus aureus N315"
xref: Reactome:REACT_115146 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H, Staphylococcus aureus N315"
xref: Reactome:REACT_115227 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H, Staphylococcus aureus N315"
xref: Reactome:REACT_16971 "3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+, Homo sapiens"
xref: Reactome:REACT_16976 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+, Homo sapiens"
xref: Reactome:REACT_1908 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H, Homo sapiens"
xref: Reactome:REACT_21320 "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+, Homo sapiens"
xref: Reactome:REACT_2187 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H, Homo sapiens"
xref: Reactome:REACT_2195 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H, Homo sapiens"
xref: Reactome:REACT_2238 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Homo sapiens"
xref: Reactome:REACT_242 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H, Homo sapiens"
xref: Reactome:REACT_28171 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA, Arabidopsis thaliana"
xref: Reactome:REACT_28279 "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+, Taeniopygia guttata"
xref: Reactome:REACT_28310 "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H, Danio rerio"
xref: Reactome:REACT_28475 "3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+, Mus musculus"
xref: Reactome:REACT_28502 "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H, Sus scrofa"
xref: Reactome:REACT_28542 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H, Gallus gallus"
xref: Reactome:REACT_28734 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H, Danio rerio"
xref: Reactome:REACT_28832 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H, Escherichia coli"
xref: Reactome:REACT_28849 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H, Dictyostelium discoideum"
xref: Reactome:REACT_29078 "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H, Mycobacterium tuberculosis"
xref: Reactome:REACT_29670 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+, Mus musculus"
xref: Reactome:REACT_29976 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA, Mus musculus"
xref: Reactome:REACT_29995 "3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+, Oryza sativa"
xref: Reactome:REACT_29997 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H, Rattus norvegicus"
xref: Reactome:REACT_30800 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H, Mus musculus"
xref: Reactome:REACT_30941 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H, Taeniopygia guttata"
xref: Reactome:REACT_31004 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+, Bos taurus"
xref: Reactome:REACT_31541 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA, Danio rerio"
xref: Reactome:REACT_31820 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Rattus norvegicus"
xref: Reactome:REACT_31990 "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+, Sus scrofa"
xref: Reactome:REACT_32500 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H, Taeniopygia guttata"
xref: Reactome:REACT_32695 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Danio rerio"
xref: Reactome:REACT_32848 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA, Rattus norvegicus"
xref: Reactome:REACT_33031 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Sus scrofa"
xref: Reactome:REACT_33370 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA, Drosophila melanogaster"
xref: Reactome:REACT_33795 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Taeniopygia guttata"
xref: Reactome:REACT_33854 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H, Arabidopsis thaliana"
xref: Reactome:REACT_34140 "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+, Mycobacterium tuberculosis"
xref: Reactome:REACT_343 "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H, Homo sapiens"
xref: Reactome:REACT_34604 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+, Oryza sativa"
xref: Reactome:REACT_34731 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H, Escherichia coli"
xref: Reactome:REACT_440 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Homo sapiens"
xref: Reactome:REACT_447 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H, Homo sapiens"
xref: Reactome:REACT_457 "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+, Homo sapiens"
xref: Reactome:REACT_488 "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H, Homo sapiens"
xref: Reactome:REACT_76935 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H, Gallus gallus"
xref: Reactome:REACT_77072 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H, Bos taurus"
xref: Reactome:REACT_77100 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H, Mus musculus"
xref: Reactome:REACT_77507 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H, Taeniopygia guttata"
xref: Reactome:REACT_77574 "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+, Bos taurus"
xref: Reactome:REACT_78964 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H, Rattus norvegicus"
xref: Reactome:REACT_78989 "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H, Xenopus tropicalis"
xref: Reactome:REACT_79125 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H, Oryza sativa"
xref: Reactome:REACT_79280 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H, Canis familiaris"
xref: Reactome:REACT_79436 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H, Dictyostelium discoideum"
xref: Reactome:REACT_79907 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H, Taeniopygia guttata"
xref: Reactome:REACT_79918 "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H, Gallus gallus"
xref: Reactome:REACT_80029 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H, Rattus norvegicus"
xref: Reactome:REACT_80406 "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H, Bos taurus"
xref: Reactome:REACT_80423 "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H, Mycobacterium tuberculosis"
xref: Reactome:REACT_80706 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Rattus norvegicus"
xref: Reactome:REACT_80985 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H, Mus musculus"
xref: Reactome:REACT_81132 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H, Canis familiaris"
xref: Reactome:REACT_81339 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H, Oryza sativa"
xref: Reactome:REACT_81483 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Mus musculus"
xref: Reactome:REACT_81715 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA, Saccharomyces cerevisiae"
xref: Reactome:REACT_81942 "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H, Drosophila melanogaster"
xref: Reactome:REACT_82010 "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H, Gallus gallus"
xref: Reactome:REACT_82448 "3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+, Bos taurus"
xref: Reactome:REACT_82560 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H, Bos taurus"
xref: Reactome:REACT_82705 "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H, Mus musculus"
xref: Reactome:REACT_83211 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA, Saccharomyces cerevisiae"
xref: Reactome:REACT_83233 "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+, Drosophila melanogaster"
xref: Reactome:REACT_83339 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H, Arabidopsis thaliana"
xref: Reactome:REACT_83343 "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H, Taeniopygia guttata"
xref: Reactome:REACT_83521 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H, Taeniopygia guttata"
xref: Reactome:REACT_83685 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H, Dictyostelium discoideum"
xref: Reactome:REACT_83929 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA, Oryza sativa"
xref: Reactome:REACT_84012 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA, Drosophila melanogaster"
xref: Reactome:REACT_84185 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H, Arabidopsis thaliana"
xref: Reactome:REACT_84732 "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H, Danio rerio"
xref: Reactome:REACT_85076 "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+, Danio rerio"
xref: Reactome:REACT_85352 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+, Drosophila melanogaster"
xref: Reactome:REACT_86008 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H, Rattus norvegicus"
xref: Reactome:REACT_86054 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA, Canis familiaris"
xref: Reactome:REACT_86074 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Taeniopygia guttata"
xref: Reactome:REACT_86077 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Gallus gallus"
xref: Reactome:REACT_86330 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Mus musculus"
xref: Reactome:REACT_86348 "3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+, Canis familiaris"
xref: Reactome:REACT_87006 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Bos taurus"
xref: Reactome:REACT_87192 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H, Danio rerio"
xref: Reactome:REACT_87443 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+, Canis familiaris"
xref: Reactome:REACT_87448 "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H, Rattus norvegicus"
xref: Reactome:REACT_87532 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA, Bos taurus"
xref: Reactome:REACT_88318 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H, Caenorhabditis elegans"
xref: Reactome:REACT_88762 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Mycobacterium tuberculosis"
xref: Reactome:REACT_88921 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H, Canis familiaris"
xref: Reactome:REACT_89448 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA, Taeniopygia guttata"
xref: Reactome:REACT_89623 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H, Mycobacterium tuberculosis"
xref: Reactome:REACT_89867 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H, Xenopus tropicalis"
xref: Reactome:REACT_89919 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H, Mycobacterium tuberculosis"
xref: Reactome:REACT_90143 "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+, Mus musculus"
xref: Reactome:REACT_90989 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H, Arabidopsis thaliana"
xref: Reactome:REACT_91027 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA, Dictyostelium discoideum"
xref: Reactome:REACT_91170 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H, Mycobacterium tuberculosis"
xref: Reactome:REACT_91389 "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H, Rattus norvegicus"
xref: Reactome:REACT_91693 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA, Bos taurus"
xref: Reactome:REACT_91746 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA, Gallus gallus"
xref: Reactome:REACT_91758 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H, Sus scrofa"
xref: Reactome:REACT_92399 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H, Caenorhabditis elegans"
xref: Reactome:REACT_92535 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Xenopus tropicalis"
xref: Reactome:REACT_92615 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H, Xenopus tropicalis"
xref: Reactome:REACT_92737 "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+, Xenopus tropicalis"
xref: Reactome:REACT_93233 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA, Danio rerio"
xref: Reactome:REACT_93724 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H, Bos taurus"
xref: Reactome:REACT_93920 "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+, Canis familiaris"
xref: Reactome:REACT_93932 "3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+, Danio rerio"
xref: Reactome:REACT_94022 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+, Saccharomyces cerevisiae"
xref: Reactome:REACT_94076 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Mycobacterium tuberculosis"
xref: Reactome:REACT_94192 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+, Dictyostelium discoideum"
xref: Reactome:REACT_94248 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H, Oryza sativa"
xref: Reactome:REACT_94489 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA, Dictyostelium discoideum"
xref: Reactome:REACT_94548 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Gallus gallus"
xref: Reactome:REACT_95062 "3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+, Gallus gallus"
xref: Reactome:REACT_95378 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Xenopus tropicalis"
xref: Reactome:REACT_95512 "3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+, Xenopus tropicalis"
xref: Reactome:REACT_95608 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H, Sus scrofa"
xref: Reactome:REACT_95831 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA, Oryza sativa"
xref: Reactome:REACT_95994 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H, Sus scrofa"
xref: Reactome:REACT_96433 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA, Taeniopygia guttata"
xref: Reactome:REACT_96601 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H, Arabidopsis thaliana"
xref: Reactome:REACT_96805 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA, Mus musculus"
xref: Reactome:REACT_96911 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H, Xenopus tropicalis"
xref: Reactome:REACT_97617 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+, Rattus norvegicus"
xref: Reactome:REACT_97730 "3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+, Arabidopsis thaliana"
xref: Reactome:REACT_97950 "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H, Bos taurus"
xref: Reactome:REACT_98096 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA, Gallus gallus"
xref: Reactome:REACT_98191 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H, Rattus norvegicus"
xref: Reactome:REACT_98235 "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H, Caenorhabditis elegans"
xref: Reactome:REACT_98465 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H, Oryza sativa"
xref: Reactome:REACT_98828 "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+, Rattus norvegicus"
xref: Reactome:REACT_98881 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H, Mus musculus"
xref: Reactome:REACT_98895 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA, Xenopus tropicalis"
xref: Reactome:REACT_99003 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H, Sus scrofa"
xref: Reactome:REACT_99129 "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H, Xenopus tropicalis"
xref: Reactome:REACT_99158 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H, Caenorhabditis elegans"
xref: Reactome:REACT_99256 "3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+, Drosophila melanogaster"
xref: Reactome:REACT_99335 "3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+, Taeniopygia guttata"
xref: Reactome:REACT_99549 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H, Mus musculus"
xref: Reactome:REACT_9967 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA, Homo sapiens"
xref: Reactome:REACT_99725 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+, Danio rerio"
xref: Reactome:REACT_99776 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Bos taurus"
xref: RHEA:22435
xref: UM-BBD_enzymeID:e0664
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0003858
name: 3-hydroxybutyrate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-3-hydroxybutanoate + NAD(+) = acetoacetate + H(+) + NADH." [EC:1.1.1.30, RHEA:20524]
subset: gosubset_prok
synonym: "D-beta-hydroxybutyrate dehydrogenase activity" EXACT [EC:1.1.1.30]
xref: EC:1.1.1.30
xref: KEGG:R01361
xref: MetaCyc:3-HYDROXYBUTYRATE-DEHYDROGENASE-RXN
xref: Reactome:REACT_100598 "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+, Taeniopygia guttata"
xref: Reactome:REACT_100701 "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+, Gallus gallus"
xref: Reactome:REACT_101716 "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+, Escherichia coli"
xref: Reactome:REACT_103885 "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+, Canis familiaris"
xref: Reactome:REACT_104408 "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+, Sus scrofa"
xref: Reactome:REACT_108608 "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+, Danio rerio"
xref: Reactome:REACT_110558 "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+, Taeniopygia guttata"
xref: Reactome:REACT_1493 "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+, Homo sapiens"
xref: Reactome:REACT_31121 "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+, Bos taurus"
xref: Reactome:REACT_31745 "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+, Mus musculus"
xref: Reactome:REACT_32814 "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+, Rattus norvegicus"
xref: Reactome:REACT_631 "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+, Homo sapiens"
xref: Reactome:REACT_81074 "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+, Mus musculus"
xref: Reactome:REACT_84906 "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+, Sus scrofa"
xref: Reactome:REACT_85059 "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+, Xenopus tropicalis"
xref: Reactome:REACT_87253 "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+, Bos taurus"
xref: Reactome:REACT_87733 "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+, Gallus gallus"
xref: Reactome:REACT_89789 "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+, Escherichia coli"
xref: Reactome:REACT_90360 "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+, Xenopus tropicalis"
xref: Reactome:REACT_91670 "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+, Rattus norvegicus"
xref: Reactome:REACT_95508 "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+, Canis familiaris"
xref: Reactome:REACT_97547 "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+, Danio rerio"
xref: RHEA:20524
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0003859
name: 3-hydroxybutyryl-CoA dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-3-hydroxybutanoyl-CoA = crotonoyl-CoA + H(2)O." [EC:4.2.1.55, RHEA:17852]
subset: gosubset_prok
synonym: "(3R)-3-hydroxybutanoyl-CoA hydro-lyase (crotonoyl-CoA-forming)" EXACT [EC:4.2.1.55]
synonym: "(3R)-3-hydroxybutanoyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.55]
synonym: "crotonase activity" EXACT [EC:4.2.1.55]
synonym: "D-3-hydroxybutyryl coenzyme A dehydratase activity" EXACT [EC:4.2.1.55]
synonym: "D-3-hydroxybutyryl-CoA dehydratase activity" EXACT [EC:4.2.1.55]
synonym: "enoyl coenzyme A hydrase (D)" BROAD [EC:4.2.1.55]
xref: EC:4.2.1.55
xref: KEGG:R03027
xref: MetaCyc:3-HYDROXBUTYRYL-COA-DEHYDRATASE-RXN
xref: RHEA:17852
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0003860
name: 3-hydroxyisobutyryl-CoA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-hydroxy-2-methylpropanoate." [EC:3.1.2.4]
subset: gosubset_prok
synonym: "3-hydroxy-2-methylpropanoyl-CoA hydrolase activity" EXACT [EC:3.1.2.4]
synonym: "3-hydroxy-isobutyryl CoA hydrolase activity" EXACT [EC:3.1.2.4]
synonym: "HIB CoA deacylase activity" EXACT [EC:3.1.2.4]
xref: EC:3.1.2.4
xref: MetaCyc:3-HYDROXYISOBUTYRYL-COA-HYDROLASE-RXN
xref: Reactome:REACT_101449 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Canis familiaris"
xref: Reactome:REACT_102854 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Bos taurus"
xref: Reactome:REACT_104494 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Mus musculus"
xref: Reactome:REACT_106977 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Gallus gallus"
xref: Reactome:REACT_107222 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Drosophila melanogaster"
xref: Reactome:REACT_111014 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Taeniopygia guttata"
xref: Reactome:REACT_115031 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Arabidopsis thaliana"
xref: Reactome:REACT_29772 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Saccharomyces cerevisiae"
xref: Reactome:REACT_34277 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Plasmodium falciparum"
xref: Reactome:REACT_77522 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Oryza sativa"
xref: Reactome:REACT_78256 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Dictyostelium discoideum"
xref: Reactome:REACT_83318 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Schizosaccharomyces pombe"
xref: Reactome:REACT_919 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Homo sapiens"
xref: Reactome:REACT_92394 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Caenorhabditis elegans"
xref: Reactome:REACT_93703 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Danio rerio"
xref: Reactome:REACT_95071 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Mycobacterium tuberculosis"
xref: Reactome:REACT_96788 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Rattus norvegicus"
xref: Reactome:REACT_97387 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Xenopus tropicalis"
xref: Reactome:REACT_99747 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Sus scrofa"
xref: RHEA:20891
is_a: GO:0016289 ! CoA hydrolase activity

[Term]
id: GO:0003861
name: 3-isopropylmalate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-isopropylmalate = 2-isopropylmaleate + H2O." [EC:4.2.1.33]
subset: gosubset_prok
synonym: "(2R,3S)-3-isopropylmalate hydro-lyase (2-isopropylmaleate-forming)" EXACT [EC:4.2.1.33]
synonym: "(2R,3S)-3-isopropylmalate hydro-lyase activity" EXACT [EC:4.2.1.33]
synonym: "alpha-IPM isomerase activity" EXACT [EC:4.2.1.33]
synonym: "alpha-isopropylmalate isomerase activity" EXACT [EC:4.2.1.33]
synonym: "beta-isopropylmalate dehydratase activity" EXACT [EC:4.2.1.33]
synonym: "isopropylmalate isomerase activity" EXACT [EC:4.2.1.33]
xref: EC:4.2.1.33
xref: MetaCyc:3-ISOPROPYLMALISOM-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0003862
name: 3-isopropylmalate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-carboxy-2-hydroxy-4-methylpentanoate + NAD+ = 3-carboxy-4-methyl-2-oxopentanoate + NADH + H+." [EC:1.1.1.85]
subset: gosubset_prok
synonym: "(2R,3S)-3-isopropylmalate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.85]
synonym: "3-carboxy-2-hydroxy-4-methylpentanoate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.85]
synonym: "beta-IPM dehydrogenase activity" EXACT [EC:1.1.1.85]
synonym: "beta-isopropylmalate dehydrogenase activity" EXACT [EC:1.1.1.85]
synonym: "beta-isopropylmalic enzyme" RELATED [EC:1.1.1.85]
synonym: "IMDH activity" EXACT [EC:1.1.1.85]
synonym: "IPMDH" RELATED [EC:1.1.1.85]
synonym: "threo-Ds-3-isopropylmalate dehydrogenase activity" EXACT [EC:1.1.1.85]
xref: EC:1.1.1.85
xref: MetaCyc:3-ISOPROPYLMALDEHYDROG-RXN
xref: RHEA:25082
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0003863
name: 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)dihydrolipoamide + CO2." [EC:1.2.4.4]
subset: gosubset_prok
synonym: "2-oxoisocaproate dehydrogenase activity" EXACT [EC:1.2.4.4]
synonym: "2-oxoisovalerate (lipoate) dehydrogenase activity" EXACT [EC:1.2.4.4]
synonym: "3-methyl-2-oxobutanoate dehydrogenase (lipoamide) activity" EXACT [EC:1.2.4.4]
synonym: "3-methyl-2-oxobutanoate:dihydrolipoyllysine-residue (2-methylpropanoyl)transferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating)" EXACT [EC:1.2.4.4]
synonym: "3-methyl-2-oxobutanoate:lipoamide oxidoreductase (decarboxylating and acceptor-2-methylpropanoylating) activity" EXACT [EC:1.2.4.4]
synonym: "alpha-keto-alpha-methylvalerate dehydrogenase activity" EXACT [EC:1.2.4.4]
synonym: "alpha-ketoisocaproate dehydrogenase activity" EXACT [EC:1.2.4.4]
synonym: "alpha-ketoisocaproic dehydrogenase activity" EXACT [EC:1.2.4.4]
synonym: "alpha-ketoisocaproic-alpha-keto-alpha-methylvaleric dehydrogenase activity" EXACT [EC:1.2.4.4]
synonym: "alpha-ketoisovalerate dehydrogenase activity" EXACT [EC:1.2.4.4]
synonym: "alpha-oxoisocaproate dehydrogenase activity" EXACT [EC:1.2.4.4]
synonym: "BCKDH activity" RELATED [EC:1.2.4.4]
synonym: "BCOAD activity" RELATED [EC:1.2.4.4]
synonym: "branched chain keto acid dehydrogenase activity" RELATED [EC:1.2.4.4]
synonym: "branched-chain (-2-oxoacid) dehydrogenase (BCD) activity" RELATED [EC:1.2.4.4]
synonym: "branched-chain 2-keto acid dehydrogenase activity" RELATED [EC:1.2.4.4]
synonym: "branched-chain 2-oxo acid dehydrogenase activity" RELATED [EC:1.2.4.4]
synonym: "branched-chain alpha-keto acid dehydrogenase activity" RELATED [EC:1.2.4.4]
synonym: "branched-chain alpha-oxo acid dehydrogenase activity" RELATED [EC:1.2.4.4]
synonym: "branched-chain keto acid dehydrogenase activity" RELATED [EC:1.2.4.4]
synonym: "branched-chain ketoacid dehydrogenase activity" RELATED [EC:1.2.4.4]
synonym: "dehydrogenase, 2-oxoisovalerate (lipoate) activity" EXACT [EC:1.2.4.4]
synonym: "dehydrogenase, branched chain alpha-keto acid activity" RELATED [EC:1.2.4.4]
xref: EC:1.2.4.4
xref: MetaCyc:1.2.4.4-RXN
is_a: GO:0016624 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor

[Term]
id: GO:0003864
name: 3-methyl-2-oxobutanoate hydroxymethyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate = tetrahydrofolate + 2-dehydropantoate." [EC:2.1.2.11]
subset: gosubset_prok
synonym: "5,10-methylene tetrahydrofolate:alpha-ketoisovalerate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11]
synonym: "5,10-methylenetetrahydrofolate:3-methyl-2-oxobutanoate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11]
synonym: "alpha-ketoisovalerate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11]
synonym: "dehydropantoate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11]
synonym: "ketopantoate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11]
synonym: "oxopantoate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11]
xref: EC:2.1.2.11
xref: MetaCyc:3-CH3-2-OXOBUTANOATE-OH-CH3-XFER-RXN
xref: RHEA:11827
is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity

[Term]
id: GO:0003865
name: 3-oxo-5-alpha-steroid 4-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-delta(4)-steroid + reduced acceptor." [EC:1.3.99.5]
synonym: "3-keto-delta4-steroid-5alpha-reductase activity" EXACT [EC:1.3.99.5]
synonym: "3-oxo-5alpha-steroid 4-dehydrogenase activity" EXACT [EC:1.3.99.5]
synonym: "3-oxo-5alpha-steroid delta4-dehydrogenase activity" EXACT [EC:1.3.99.5]
synonym: "3-oxo-5alpha-steroid:(acceptor) delta4-oxidoreductase activity" EXACT [EC:1.3.99.5]
synonym: "3-oxo-5alpha-steroid:acceptor delta4-oxidoreductase activity" EXACT [EC:1.3.99.5]
synonym: "3-oxosteroid delta4-dehydrogenase" BROAD [EC:1.3.99.5]
synonym: "4-ene-3-ketosteroid-5alpha-oxidoreductase activity" EXACT [EC:1.3.99.5]
synonym: "5alpha-reductase" BROAD [EC:1.3.99.5]
synonym: "delta4-3-keto steroid 5alpha-reductase activity" EXACT [EC:1.3.99.5]
synonym: "delta4-3-ketosteroid5alpha-oxidoreductase activity" EXACT [EC:1.3.99.5]
synonym: "delta4-3-oxo steroid reductase activity" EXACT [EC:1.3.99.5]
synonym: "delta4-3-oxosteroid-5alpha-reductase" BROAD [EC:1.3.99.5]
synonym: "delta4-5alpha-dehydrogenase activity" EXACT [EC:1.3.99.5]
synonym: "steroid 5 alpha reductase" BROAD [EC:1.3.99.5]
synonym: "steroid 5-alpha-reductase activity" BROAD [EC:1.3.99.5]
synonym: "steroid 5alpha-reductase" BROAD [EC:1.3.99.5]
synonym: "steroid delta4-5alpha-reductase activity" EXACT [EC:1.3.99.5]
synonym: "testosterone 5alpha-reductase" BROAD [EC:1.3.99.5]
xref: EC:1.3.99.5
xref: MetaCyc:1.3.99.5-RXN
xref: Reactome:REACT_22210 "Testosterone is converted to 5-alpha-dihydroxytestosterone, Homo sapiens"
is_a: GO:0033765 ! steroid dehydrogenase activity, acting on the CH-CH group of donors

[Term]
id: GO:0003866
name: 3-phosphoshikimate 1-carboxyvinyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate." [EC:2.5.1.19, RHEA:21259]
subset: gosubset_prok
synonym: "3-enol-pyruvoylshikimate-5-phosphate synthase activity" EXACT [EC:2.5.1.19]
synonym: "5-enolpyruvylshikimate-3-phosphate synthase activity" EXACT [EC:2.5.1.19]
synonym: "EPSP synthase activity" EXACT [EC:2.5.1.19]
synonym: "phosphoenolpyruvate:3-phosphoshikimate 5-O-(1-carboxyvinyl)-transferase activity" EXACT [EC:2.5.1.19]
xref: EC:2.5.1.19
xref: KEGG:R03460
xref: MetaCyc:2.5.1.19-RXN
xref: Reactome:REACT_27315 "EPSP from shikimate 3-phosphate, Mycobacterium tuberculosis"
xref: RHEA:21259
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0003867
name: 4-aminobutyrate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-aminobutanoate + amino group acceptor = succinate semialdehyde + amino acid." [EC:2.6.1.19, GOC:mah]
subset: gosubset_prok
synonym: "4-aminobutanoate transaminase activity" EXACT []
synonym: "4-aminobutyrate aminotransferase activity" EXACT []
synonym: "4-aminobutyric acid aminotransferase activity" EXACT [EC:2.6.1.19]
synonym: "aminobutyrate aminotransferase activity" EXACT [EC:2.6.1.19]
synonym: "aminobutyrate transaminase activity" EXACT [EC:2.6.1.19]
synonym: "beta-alanine aminotransferase" RELATED [EC:2.6.1.19]
synonym: "beta-alanine--oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.19]
synonym: "beta-alanine-oxoglutarate transaminase activity" RELATED [EC:2.6.1.19]
synonym: "GABA aminotransferase activity" EXACT [EC:2.6.1.19]
synonym: "GABA transaminase activity" EXACT []
synonym: "GABA transferase activity" EXACT [EC:2.6.1.19]
synonym: "gamma-amino-N-butyrate transaminase activity" EXACT [EC:2.6.1.19]
synonym: "gamma-aminobutyrate aminotransaminase activity" EXACT [EC:2.6.1.19]
synonym: "gamma-aminobutyrate transaminase activity" EXACT [EC:2.6.1.19]
synonym: "gamma-aminobutyric acid aminotransferase activity" EXACT [EC:2.6.1.19]
synonym: "gamma-aminobutyric acid transaminase activity" EXACT []
synonym: "gamma-aminobutyric transaminase activity" EXACT [EC:2.6.1.19]
synonym: "glutamate-succinic semialdehyde transaminase activity" EXACT [EC:2.6.1.19]
xref: EC:2.6.1.19
xref: MetaCyc:GABATRANSAM-RXN
xref: Reactome:REACT_23980 "Conversion of GABA to Succinate Semialdehyde, Homo sapiens"
xref: RHEA:23355
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0003868
name: 4-hydroxyphenylpyruvate dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2." [EC:1.13.11.27]
subset: gosubset_prok
synonym: "4-hydroxyphenylpyruvate hydroxylase activity" EXACT [EC:1.13.11.27]
synonym: "4-hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating, decarboxylating)" EXACT [EC:1.13.11.27]
synonym: "4-hydroxyphenylpyruvic acid dioxygenase activity" EXACT [EC:1.13.11.27]
synonym: "p-hydroxyphenylpyruvate dioxygenase activity" EXACT [EC:1.13.11.27]
synonym: "p-hydroxyphenylpyruvate hydroxylase activity" EXACT [EC:1.13.11.27]
synonym: "p-hydroxyphenylpyruvate oxidase activity" EXACT [EC:1.13.11.27]
synonym: "p-hydroxyphenylpyruvic acid hydroxylase activity" EXACT [EC:1.13.11.27]
synonym: "p-hydroxyphenylpyruvic hydroxylase activity" EXACT [EC:1.13.11.27]
synonym: "p-hydroxyphenylpyruvic oxidase activity" EXACT [EC:1.13.11.27]
xref: EC:1.13.11.27
xref: MetaCyc:4-HYDROXYPHENYLPYRUVATE-DIOXYGENASE-RXN
xref: Reactome:REACT_101650 "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2, Bos taurus"
xref: Reactome:REACT_1145 "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2, Homo sapiens"
xref: Reactome:REACT_29808 "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2, Rattus norvegicus"
xref: Reactome:REACT_33537 "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2, Mus musculus"
xref: Reactome:REACT_33740 "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2, Drosophila melanogaster"
xref: Reactome:REACT_77319 "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2, Danio rerio"
xref: Reactome:REACT_77991 "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2, Sus scrofa"
xref: Reactome:REACT_81665 "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2, Arabidopsis thaliana"
xref: Reactome:REACT_85018 "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2, Oryza sativa"
xref: Reactome:REACT_86998 "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2, Taeniopygia guttata"
xref: Reactome:REACT_92448 "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2, Canis familiaris"
xref: Reactome:REACT_93903 "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2, Gallus gallus"
xref: Reactome:REACT_94777 "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2, Xenopus tropicalis"
xref: Reactome:REACT_95395 "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2, Caenorhabditis elegans"
xref: Reactome:REACT_99639 "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2, Dictyostelium discoideum"
xref: RHEA:16192
xref: UM-BBD_reactionID:r0298
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0003870
name: 5-aminolevulinate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycine + H(+) + succinyl-CoA = 5-aminolevulinate + CO(2) + CoA." [EC:2.3.1.37, RHEA:12924]
subset: gosubset_prok
synonym: "5-aminolevulinate synthetase activity" EXACT [EC:2.3.1.37]
synonym: "5-aminolevulinic acid synthase activity" EXACT [EC:2.3.1.37]
synonym: "5-aminolevulinic acid synthetase activity" EXACT [EC:2.3.1.37]
synonym: "ALA synthase activity" EXACT [EC:2.3.1.37]
synonym: "ALA synthetase activity" EXACT [EC:2.3.1.37]
synonym: "ALAS activity" EXACT [EC:2.3.1.37]
synonym: "alpha-aminolevulinic acid synthase activity" EXACT [EC:2.3.1.37]
synonym: "aminolevulinate synthase activity" EXACT [EC:2.3.1.37]
synonym: "aminolevulinate synthetase activity" EXACT [EC:2.3.1.37]
synonym: "aminolevulinic acid synthase activity" EXACT [EC:2.3.1.37]
synonym: "aminolevulinic acid synthetase activity" EXACT [EC:2.3.1.37]
synonym: "aminolevulinic synthetase activity" EXACT [EC:2.3.1.37]
synonym: "delta-ALA synthetase activity" EXACT [EC:2.3.1.37]
synonym: "delta-aminolevulinate synthase activity" EXACT [EC:2.3.1.37]
synonym: "delta-aminolevulinate synthetase activity" EXACT [EC:2.3.1.37]
synonym: "delta-aminolevulinic acid synthase activity" EXACT [EC:2.3.1.37]
synonym: "delta-aminolevulinic acid synthetase activity" EXACT [EC:2.3.1.37]
synonym: "delta-aminolevulinic synthetase activity" EXACT [EC:2.3.1.37]
synonym: "succinyl-CoA:glycine C-succinyltransferase (decarboxylating)" EXACT [EC:2.3.1.37]
xref: EC:2.3.1.37
xref: KEGG:R00830
xref: MetaCyc:5-AMINOLEVULINIC-ACID-SYNTHASE-RXN
xref: Reactome:REACT_100294 "Succinyl CoA and glycine condense to form 5-aminolevulinate (ALA), Dictyostelium discoideum"
xref: Reactome:REACT_100365 "Succinyl CoA and glycine condense to form 5-aminolevulinate (ALA), Taeniopygia guttata"
xref: Reactome:REACT_101248 "Succinyl CoA and glycine condense to form 5-aminolevulinate (ALA), Rattus norvegicus"
xref: Reactome:REACT_101495 "Succinyl CoA and glycine condense to form 5-aminolevulinate (ALA), Bos taurus"
xref: Reactome:REACT_105074 "Succinyl CoA and glycine condense to form 5-aminolevulinate (ALA), Drosophila melanogaster"
xref: Reactome:REACT_106523 "Succinyl CoA and glycine condense to form 5-aminolevulinate (ALA), Mus musculus"
xref: Reactome:REACT_107818 "Succinyl CoA and glycine condense to form 5-aminolevulinate (ALA), Canis familiaris"
xref: Reactome:REACT_116003 "succinyl-CoA + glycine => delta-aminolevulinate + CoA SH + CO2, Gallus gallus"
xref: Reactome:REACT_33006 "Succinyl CoA and glycine condense to form 5-aminolevulinate (ALA), Danio rerio"
xref: Reactome:REACT_84625 "Succinyl CoA and glycine condense to form 5-aminolevulinate (ALA), Plasmodium falciparum"
xref: Reactome:REACT_86826 "Succinyl CoA and glycine condense to form 5-aminolevulinate (ALA), Xenopus tropicalis"
xref: Reactome:REACT_89048 "Succinyl CoA and glycine condense to form 5-aminolevulinate (ALA), Sus scrofa"
xref: Reactome:REACT_9463 "Succinyl CoA and glycine condense to form 5-aminolevulinate (ALA), Homo sapiens"
xref: Reactome:REACT_96967 "Succinyl CoA and glycine condense to form 5-aminolevulinate (ALA), Saccharomyces cerevisiae"
xref: Reactome:REACT_97632 "Succinyl CoA and glycine condense to form 5-aminolevulinate (ALA), Gallus gallus"
xref: Reactome:REACT_98622 "Succinyl CoA and glycine condense to form 5-aminolevulinate (ALA), Schizosaccharomyces pombe"
xref: RHEA:12924
is_a: GO:0016749 ! N-succinyltransferase activity

[Term]
id: GO:0003871
name: 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate." [EC:2.1.1.14, RHEA:21199]
subset: gosubset_prok
synonym: "5-methyltetrahydropteroyltri-L-glutamate:L-homocysteine S-methyltransferase activity" EXACT [EC:2.1.1.14]
synonym: "cobalamin-independent methionine synthase activity" EXACT [EC:2.1.1.14]
synonym: "homocysteine methylase activity" EXACT [EC:2.1.1.14]
synonym: "MetE" RELATED [EC:2.1.1.14]
synonym: "methionine synthase (cobalamin-independent) activity" EXACT [EC:2.1.1.14]
synonym: "methyltetrahydropteroylpolyglutamate:homocysteine methyltransferase activity" EXACT [EC:2.1.1.14]
synonym: "methyltransferase, tetrahydropteroylglutamate-homocysteine transmethylase activity" EXACT [EC:2.1.1.14]
synonym: "tetrahydropteroylglutamate-homocysteine transmethylase activity" EXACT [EC:2.1.1.14]
synonym: "tetrahydropteroyltriglutamate methyltransferase activity" EXACT [EC:2.1.1.14]
xref: EC:2.1.1.14
xref: KEGG:R04405
xref: MetaCyc:HOMOCYSMET-RXN
xref: RHEA:21199
is_a: GO:0008172 ! S-methyltransferase activity
is_a: GO:0042085 ! 5-methyltetrahydropteroyltri-L-glutamate-dependent methyltransferase activity

[Term]
id: GO:0003872
name: 6-phosphofructokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-fructose-6-phosphate = ADP + D-fructose 1,6-bisphosphate." [EC:2.7.1.11]
subset: gosubset_prok
synonym: "6-phosphofructokinase reduction" EXACT []
synonym: "6-phosphofructose 1-kinase activity" EXACT [EC:2.7.1.11]
synonym: "ATP-dependent phosphofructokinase activity" EXACT [EC:2.7.1.11]
synonym: "ATP:D-fructose-6-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.11]
synonym: "D-fructose-6-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.11]
synonym: "fructose 6-phosphate kinase activity" EXACT [EC:2.7.1.11]
synonym: "fructose 6-phosphokinase activity" EXACT [EC:2.7.1.11]
synonym: "nucleotide triphosphate-dependent phosphofructokinase activity" EXACT [EC:2.7.1.11]
synonym: "PFK" RELATED [EC:2.7.1.11]
synonym: "phospho-1,6-fructokinase activity" EXACT [EC:2.7.1.11]
synonym: "phosphofructokinase (phosphorylating)" EXACT [EC:2.7.1.11]
synonym: "phosphofructokinase I activity" EXACT [EC:2.7.1.11]
synonym: "phosphohexokinase activity" BROAD [EC:2.7.1.11]
xref: EC:2.7.1.11
xref: MetaCyc:6PFRUCTPHOS-RXN
xref: Reactome:REACT_102109 "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP, Taeniopygia guttata"
xref: Reactome:REACT_106558 "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP, Saccharomyces cerevisiae"
xref: Reactome:REACT_107208 "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP, Danio rerio"
xref: Reactome:REACT_109655 "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP, Mycobacterium tuberculosis"
xref: Reactome:REACT_110932 "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP, Gallus gallus"
xref: Reactome:REACT_112049 "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP, Oryza sativa"
xref: Reactome:REACT_114580 "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP, Arabidopsis thaliana"
xref: Reactome:REACT_115926 "fructose 6-phosphate + ATP => fructose 1,6-bisphosphate + ADP, Gallus gallus"
xref: Reactome:REACT_31439 "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP, Escherichia coli"
xref: Reactome:REACT_32340 "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP, Staphylococcus aureus N315"
xref: Reactome:REACT_736 "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP, Homo sapiens"
xref: Reactome:REACT_77055 "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP, Schizosaccharomyces pombe"
xref: Reactome:REACT_79025 "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP, Xenopus tropicalis"
xref: Reactome:REACT_83230 "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP, Mus musculus"
xref: Reactome:REACT_84532 "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP, Drosophila melanogaster"
xref: Reactome:REACT_85052 "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP, Canis familiaris"
xref: Reactome:REACT_88450 "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP, Sus scrofa"
xref: Reactome:REACT_91497 "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP, Rattus norvegicus"
xref: Reactome:REACT_91731 "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP, Bos taurus"
xref: Reactome:REACT_96419 "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP, Dictyostelium discoideum"
xref: Reactome:REACT_97626 "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP, Caenorhabditis elegans"
xref: RHEA:16112
is_a: GO:0008443 ! phosphofructokinase activity
relationship: part_of GO:0061615 ! glycolytic process through fructose-6-phosphate

[Term]
id: GO:0003873
name: 6-phosphofructo-2-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-D-fructose 6-phosphate + ATP = beta-D-fructose 2,6-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.105, RHEA:15656]
synonym: "6-phosphofructo-2-kinase (phosphorylating)" EXACT [EC:2.7.1.105]
synonym: "6-phosphofructose 2-kinase activity" EXACT [EC:2.7.1.105]
synonym: "ATP:beta-D-fructose-6-phosphate 2-phosphotransferase activity" EXACT [EC:2.7.1.105]
synonym: "ATP:D-fructose-6-phosphate 2-phosphotransferase activity" EXACT [EC:2.7.1.105]
synonym: "fructose 6-phosphate 2-kinase activity" EXACT [EC:2.7.1.105]
synonym: "phosphofructokinase 2 activity" EXACT [EC:2.7.1.105]
xref: EC:2.7.1.105
xref: KEGG:R02732
xref: MetaCyc:6-PHOSPHOFRUCTO-2-KINASE-RXN
xref: Reactome:REACT_104172 "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP, Saccharomyces cerevisiae"
xref: Reactome:REACT_105291 "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP, Xenopus tropicalis"
xref: Reactome:REACT_107963 "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP, Danio rerio"
xref: Reactome:REACT_115709 "fructose 6-phosphate + ATP => fructose 2,6-bisphosphate + ADP, Gallus gallus"
xref: Reactome:REACT_28048 "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP, Arabidopsis thaliana"
xref: Reactome:REACT_29034 "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP, Drosophila melanogaster"
xref: Reactome:REACT_291 "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP, Homo sapiens"
xref: Reactome:REACT_29935 "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP, Rattus norvegicus"
xref: Reactome:REACT_31693 "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP, Gallus gallus"
xref: Reactome:REACT_33667 "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP, Dictyostelium discoideum"
xref: Reactome:REACT_34412 "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP, Staphylococcus aureus N315"
xref: Reactome:REACT_38435 "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP, Schizosaccharomyces pombe"
xref: Reactome:REACT_78095 "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP, Sus scrofa"
xref: Reactome:REACT_86368 "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP, Bos taurus"
xref: Reactome:REACT_87540 "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP, Mus musculus"
xref: Reactome:REACT_88240 "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP, Oryza sativa"
xref: Reactome:REACT_91876 "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP, Taeniopygia guttata"
xref: Reactome:REACT_98327 "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP, Canis familiaris"
xref: RHEA:15656
is_a: GO:0008443 ! phosphofructokinase activity

[Term]
id: GO:0003874
name: 6-pyruvoyltetrahydropterin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + triphosphate." [EC:4.2.3.12, RHEA:22051]
subset: gosubset_prok
synonym: "2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate lyase activity" EXACT [EC:4.2.3.12]
synonym: "2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate-lyase (6-pyruvoyl-5,6,7,8-tetrahydropterin-forming)" EXACT [EC:4.2.3.12]
synonym: "6-pyruvoyl tetrahydrobiopterin synthase activity" EXACT [EC:4.2.3.12]
synonym: "PTPS activity" EXACT [EC:4.2.3.12]
xref: EC:4.2.3.12
xref: KEGG:R04286
xref: MetaCyc:4.2.3.12-RXN
xref: Reactome:REACT_111082 "DHNTP is dephosphorylated by PTPS to PTHP, Homo sapiens"
xref: RHEA:22051
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0003875
name: ADP-ribosylarginine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N2-(ADP-D-ribosyl)-L-arginine + H2O = L-arginine + ADP-ribose." [EC:3.2.2.19]
subset: gosubset_prok
synonym: "ADP-ribose-L-arginine cleavage enzyme activity" EXACT [EC:3.2.2.19]
synonym: "ADP-ribose-L-arginine cleaving enzyme activity" EXACT [EC:3.2.2.19]
synonym: "ADPribosylarginine hydrolase activity" EXACT []
synonym: "N(omega)-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity" EXACT [EC:3.2.2.19]
synonym: "nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity" EXACT [EC:3.2.2.19]
synonym: "omega-protein-N-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity" EXACT [EC:3.2.2.19]
synonym: "protein ADP-ribosylarginine hydrolase activity" EXACT [EC:3.2.2.19]
synonym: "protein-nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity" EXACT [EC:3.2.2.19]
xref: EC:3.2.2.19
xref: MetaCyc:ADP-RIBOSYLARGININE-HYDROLASE-RXN
xref: RHEA:20787
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0003876
name: AMP deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: AMP + H2O = IMP + NH3." [EC:3.5.4.6]
synonym: "5-adenylate deaminase activity" EXACT [EC:3.5.4.6]
synonym: "5-adenylic acid deaminase activity" EXACT [EC:3.5.4.6]
synonym: "5-AMP deaminase activity" EXACT [EC:3.5.4.6]
synonym: "adenosine 5-monophosphate deaminase activity" EXACT [EC:3.5.4.6]
synonym: "adenosine 5-phosphate aminohydrolase activity" EXACT [EC:3.5.4.6]
synonym: "adenosine monophosphate deaminase activity" EXACT [EC:3.5.4.6]
synonym: "adenyl deaminase activity" EXACT [EC:3.5.4.6]
synonym: "adenylate aminohydrolase activity" EXACT [EC:3.5.4.6]
synonym: "adenylate deaminase activity" EXACT [EC:3.5.4.6]
synonym: "adenylate deaminase reaction" EXACT []
synonym: "adenylate desaminase activity" EXACT [EC:3.5.4.6]
synonym: "adenylic acid deaminase activity" EXACT [EC:3.5.4.6]
synonym: "adenylic deaminase activity" EXACT [EC:3.5.4.6]
synonym: "AMP aminase activity" EXACT [EC:3.5.4.6]
synonym: "AMP aminohydrolase activity" EXACT [EC:3.5.4.6]
synonym: "myoadenylate deaminase activity" NARROW [EC:3.5.4.6]
xref: EC:3.5.4.6
xref: MetaCyc:AMP-DEAMINASE-RXN
xref: Reactome:REACT_101530 "AMP + H2O => IMP + NH3 [AMPD], Oryza sativa"
xref: Reactome:REACT_104690 "AMP + H2O => IMP + NH3 [AMPD], Gallus gallus"
xref: Reactome:REACT_105150 "AMP + H2O => IMP + NH3 [AMPD], Saccharomyces cerevisiae"
xref: Reactome:REACT_109344 "AMP + H2O => IMP + NH3 [AMPD], Plasmodium falciparum"
xref: Reactome:REACT_111015 "AMP + H2O => IMP + NH3 [AMPD], Arabidopsis thaliana"
xref: Reactome:REACT_64973 "AMP + H2O => IMP + NH3 [AMPD], Dictyostelium discoideum"
xref: Reactome:REACT_700 "AMP + H2O => IMP + NH3 [AMPD], Homo sapiens"
xref: Reactome:REACT_77256 "AMP + H2O => IMP + NH3 [AMPD], Bos taurus"
xref: Reactome:REACT_79516 "AMP + H2O => IMP + NH3 [AMPD], Canis familiaris"
xref: Reactome:REACT_79653 "AMP + H2O => IMP + NH3 [AMPD], Xenopus tropicalis"
xref: Reactome:REACT_81794 "AMP + H2O => IMP + NH3 [AMPD], Caenorhabditis elegans"
xref: Reactome:REACT_83409 "AMP + H2O => IMP + NH3 [AMPD], Sus scrofa"
xref: Reactome:REACT_87577 "AMP + H2O => IMP + NH3 [AMPD], Taeniopygia guttata"
xref: Reactome:REACT_95231 "AMP + H2O => IMP + NH3 [AMPD], Mus musculus"
xref: Reactome:REACT_98379 "AMP + H2O => IMP + NH3 [AMPD], Danio rerio"
xref: Reactome:REACT_98734 "AMP + H2O => IMP + NH3 [AMPD], Rattus norvegicus"
xref: Reactome:REACT_99903 "AMP + H2O => IMP + NH3 [AMPD], Drosophila melanogaster"
xref: RHEA:14780
is_a: GO:0047623 ! adenosine-phosphate deaminase activity

[Term]
id: GO:0003877
name: ATP adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ADP + ATP = phosphate + P(1),P(4)-bis(5'-adenosyl)tetraphosphate." [EC:2.7.7.53]
subset: gosubset_prok
synonym: "adenine triphosphate adenylyltransferase activity" EXACT [EC:2.7.7.53]
synonym: "ADP:ATP adenylyltransferase activity" EXACT []
synonym: "AP-4-A phosphorylase activity" EXACT [EC:2.7.7.53]
synonym: "bis(5'-nucleosyl)-tetraphosphate phosphorylase (NDP-forming) activity" EXACT [EC:2.7.7.53]
synonym: "diadenosine 5',5'''-P(1),P(4)-tetraphosphate phosphorylase activity" EXACT [EC:2.7.7.53]
synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate alphabeta-phosphorylase (ADP-forming)" EXACT [EC:2.7.7.53]
synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase activity" EXACT [EC:2.7.7.53]
synonym: "diadenosinetetraphosphate alpha-beta-phosphorylase activity" EXACT [EC:2.7.7.53]
synonym: "diadenosinetetraphosphate alphabeta-phosphorylase activity" EXACT [EC:2.7.7.53]
synonym: "dinucleoside oligophosphate alphabeta-phosphorylase activity" EXACT [EC:2.7.7.53]
xref: EC:2.7.7.53
xref: MetaCyc:ATP-ADENYLYLTRANSFERASE-RXN
xref: RHEA:16580
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0003878
name: ATP citrate synthase activity
namespace: molecular_function
alt_id: GO:0046913
def: "Catalysis of the reaction: acetyl-CoA + ADP + H(+) + oxaloacetate + phosphate = ATP + citrate + CoA." [EC:2.3.3.8, RHEA:21163]
comment: Note that this function was formerly EC:4.1.3.8.
synonym: "acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP- phosphorylating) activity" EXACT [EC:2.3.3.8]
synonym: "acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP-phosphorylating)" EXACT [EC:2.3.3.8]
synonym: "acetyl-CoA:oxaloacetate C-acetyltransferase [(pro-S)-carboxymethyl-forming, ADP-phosphorylating]" RELATED [EC:2.3.3.8]
synonym: "adenosine triphosphate citrate lyase activity" EXACT [EC:2.3.3.8]
synonym: "ATP citrate (pro-S)-lyase activity" EXACT [EC:2.3.3.8]
synonym: "ATP-citrate (pro-S)-lyase activity" EXACT []
synonym: "ATP-citrate (pro-S-)-lyase activity" EXACT [EC:2.3.3.8]
synonym: "ATP-citric lyase activity" EXACT [EC:2.3.3.8]
synonym: "ATP:citrate oxaloacetate-lyase ((pro-S)-CH(2)COO(-)->acetyl-CoA) (ATP- dephosphorylating) activity" EXACT [EC:2.3.3.8]
synonym: "ATP:citrate oxaloacetate-lyase [(pro-S)-CH2COO-rightacetyl-CoA] (ATP-dephosphorylating)" RELATED [EC:2.3.3.8]
synonym: "citrate cleavage enzyme activity" RELATED [EC:2.3.3.8]
synonym: "citrate-ATP lyase activity" EXACT [EC:2.3.3.8]
synonym: "citric cleavage enzyme activity" RELATED [EC:2.3.3.8]
xref: EC:2.3.3.8
xref: KEGG:R00352
xref: MetaCyc:ATP-CITRATE-PRO-S--LYASE-RXN
xref: MetaCyc:PWY-5172
xref: Reactome:REACT_103402 "Generation of Cytoplasmic Acetyl CoA from Citrate, Arabidopsis thaliana"
xref: Reactome:REACT_105575 "Generation of Cytoplasmic Acetyl CoA from Citrate, Drosophila melanogaster"
xref: Reactome:REACT_1141 "Generation of Cytoplasmic Acetyl CoA from Citrate, Homo sapiens"
xref: Reactome:REACT_114344 "Generation of Cytoplasmic Acetyl CoA from Citrate, Saccharomyces cerevisiae"
xref: Reactome:REACT_114419 "Generation of Cytoplasmic Acetyl CoA from Citrate, Caenorhabditis elegans"
xref: Reactome:REACT_29907 "Generation of Cytoplasmic Acetyl CoA from Citrate, Danio rerio"
xref: Reactome:REACT_31411 "Generation of Cytoplasmic Acetyl CoA from Citrate, Oryza sativa"
xref: Reactome:REACT_34626 "Generation of Cytoplasmic Acetyl CoA from Citrate, Xenopus tropicalis"
xref: Reactome:REACT_34711 "Generation of Cytoplasmic Acetyl CoA from Citrate, Mus musculus"
xref: Reactome:REACT_78048 "Generation of Cytoplasmic Acetyl CoA from Citrate, Schizosaccharomyces pombe"
xref: Reactome:REACT_78150 "Generation of Cytoplasmic Acetyl CoA from Citrate, Sus scrofa"
xref: Reactome:REACT_83858 "Generation of Cytoplasmic Acetyl CoA from Citrate, Canis familiaris"
xref: Reactome:REACT_86684 "Generation of Cytoplasmic Acetyl CoA from Citrate, Gallus gallus"
xref: Reactome:REACT_90155 "Generation of Cytoplasmic Acetyl CoA from Citrate, Rattus norvegicus"
xref: Reactome:REACT_92200 "Generation of Cytoplasmic Acetyl CoA from Citrate, Dictyostelium discoideum"
xref: Reactome:REACT_93895 "Generation of Cytoplasmic Acetyl CoA from Citrate, Bos taurus"
xref: Reactome:REACT_99638 "Generation of Cytoplasmic Acetyl CoA from Citrate, Taeniopygia guttata"
xref: RHEA:21163
is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

[Term]
id: GO:0003879
name: ATP phosphoribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.17]
subset: gosubset_prok
synonym: "1-(5-phospho-D-ribosyl)-ATP:diphosphate phospho-alpha-D-ribosyl-transferase activity" EXACT [EC:2.4.2.17]
synonym: "adenosine triphosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.17]
synonym: "phosphoribosyl ATP synthetase activity" EXACT [EC:2.4.2.17]
synonym: "phosphoribosyl ATP:pyrophosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.17]
synonym: "phosphoribosyl-ATP diphosphorylase activity" EXACT [EC:2.4.2.17]
synonym: "phosphoribosyl-ATP pyrophosphorylase activity" EXACT [EC:2.4.2.17]
synonym: "phosphoribosyl-ATP:pyrophosphate-phosphoribosyl phosphotransferase activity" EXACT [EC:2.4.2.17]
synonym: "phosphoribosyladenosine triphosphate pyrophosphorylase activity" EXACT [EC:2.4.2.17]
synonym: "phosphoribosyladenosine triphosphate synthetase activity" EXACT [EC:2.4.2.17]
synonym: "phosphoribosyladenosine triphosphate:pyrophosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.17]
xref: EC:2.4.2.17
xref: MetaCyc:ATPPHOSPHORIBOSYLTRANS-RXN
xref: RHEA:18476
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0003880
name: protein C-terminal carboxyl O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group to the oxygen atom of a carboxyl group at the C-terminal of a protein." [PMID:8428937]
subset: gosubset_prok
synonym: "C-terminal protein carboxyl methyltransferase activity" EXACT []
xref: EC:2.1.1.-
is_a: GO:0051998 ! protein carboxyl O-methyltransferase activity
relationship: part_of GO:0006481 ! C-terminal protein methylation

[Term]
id: GO:0003881
name: CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: myo-inositol + CDP-diacylglycerol = 1-phosphatidyl-1D-myo-inositol + CMP + H(+)." [EC:2.7.8.11, RHEA:11583]
subset: gosubset_prok
synonym: "CDP diglyceride-inositol phosphatidyltransferase activity" EXACT [EC:2.7.8.11]
synonym: "CDP-DG:inositol transferase activity" EXACT [EC:2.7.8.11]
synonym: "CDP-diacylglycerol--inositol phosphatidyltransferase activity" EXACT [EC:2.7.8.11]
synonym: "CDP-diacylglycerol:myo-inositol 3-phosphatidyltransferase activity" EXACT [EC:2.7.8.11]
synonym: "CDP-diacylglycerol:myo-inositol-3-phosphatidyltransferase activity" EXACT [EC:2.7.8.11]
synonym: "CDP-diglyceride-inositol transferase activity" EXACT [EC:2.7.8.11]
synonym: "CDP-diglyceride:inositol transferase activity" EXACT [EC:2.7.8.11]
synonym: "CDPdiacylglycerol-inositol 3-phosphatidyltransferase activity" EXACT [EC:2.7.8.11]
synonym: "cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:myo-inositol 3-phosphatidyltransferase activity" EXACT [EC:2.7.8.11]
synonym: "cytidine diphosphodiglyceride-inositol phosphatidyltransferase activity" EXACT [EC:2.7.8.11]
synonym: "cytidine diphosphoglyceride-inositol phosphatidyltransferase activity" EXACT [EC:2.7.8.11]
synonym: "cytidine diphosphoglyceride-inositol transferase activity" EXACT [EC:2.7.8.11]
synonym: "phosphatidylinositol synthase activity" EXACT []
xref: EC:2.7.8.11
xref: KEGG:R01802
xref: MetaCyc:2.7.8.11-RXN
xref: RHEA:11583
is_a: GO:0017169 ! CDP-alcohol phosphatidyltransferase activity

[Term]
id: GO:0003882
name: CDP-diacylglycerol-serine O-phosphatidyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CDP-diacylglycerol + L-serine = CMP + O-sn-phosphatidyl-L-serine." [EC:2.7.8.8]
subset: gosubset_prok
synonym: "CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8]
synonym: "CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8]
synonym: "CDP-diglyceride-L-serine phosphatidyltransferase activity" EXACT [EC:2.7.8.8]
synonym: "CDP-diglyceride:serine phosphatidyltransferase activity" EXACT [EC:2.7.8.8]
synonym: "CDP-diglycerine-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8]
synonym: "CDPdiacylglycerol-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8]
synonym: "CDPdiglyceride-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8]
synonym: "cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8]
synonym: "cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8]
synonym: "cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8]
synonym: "phosphatidylserine synthase activity" EXACT [EC:2.7.8.8]
synonym: "phosphatidylserine synthetase activity" EXACT [EC:2.7.8.8]
synonym: "PS synthase activity" EXACT [EC:2.7.8.8]
synonym: "serine exchange enzyme" BROAD []
xref: EC:2.7.8.8
xref: MetaCyc:PHOSPHASERSYN-RXN
xref: RHEA:16916
is_a: GO:0017169 ! CDP-alcohol phosphatidyltransferase activity

[Term]
id: GO:0003883
name: CTP synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + UTP + NH3 = ADP + phosphate + CTP." [EC:6.3.4.2]
subset: gosubset_prok
synonym: "CTP synthetase activity" EXACT [EC:6.3.4.2]
synonym: "cytidine 5'-triphosphate synthetase activity" EXACT [EC:6.3.4.2]
synonym: "cytidine triphosphate synthetase activity" EXACT [EC:6.3.4.2]
synonym: "uridine triphosphate aminase activity" EXACT [EC:6.3.4.2]
synonym: "UTP--ammonia ligase activity" EXACT [EC:6.3.4.2]
synonym: "UTP:ammonia ligase (ADP-forming)" EXACT [EC:6.3.4.2]
xref: EC:6.3.4.2
xref: MetaCyc:CTPSYN-RXN
xref: Reactome:REACT_101507 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS], Rattus norvegicus"
xref: Reactome:REACT_102614 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2], Xenopus tropicalis"
xref: Reactome:REACT_102874 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS], Saccharomyces cerevisiae"
xref: Reactome:REACT_105827 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2], Schizosaccharomyces pombe"
xref: Reactome:REACT_108024 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2], Plasmodium falciparum"
xref: Reactome:REACT_109286 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2], Arabidopsis thaliana"
xref: Reactome:REACT_109358 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2], Gallus gallus"
xref: Reactome:REACT_110148 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS], Taeniopygia guttata"
xref: Reactome:REACT_21305 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2], Homo sapiens"
xref: Reactome:REACT_28893 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2], Drosophila melanogaster"
xref: Reactome:REACT_29290 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS], Sus scrofa"
xref: Reactome:REACT_32806 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2], Taeniopygia guttata"
xref: Reactome:REACT_33151 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2], Saccharomyces cerevisiae"
xref: Reactome:REACT_34398 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS], Dictyostelium discoideum"
xref: Reactome:REACT_574 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS], Homo sapiens"
xref: Reactome:REACT_77809 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS], Plasmodium falciparum"
xref: Reactome:REACT_78348 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS], Mus musculus"
xref: Reactome:REACT_79156 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS], Schizosaccharomyces pombe"
xref: Reactome:REACT_79789 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2], Bos taurus"
xref: Reactome:REACT_81861 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS], Canis familiaris"
xref: Reactome:REACT_82397 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2], Oryza sativa"
xref: Reactome:REACT_83666 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2], Mus musculus"
xref: Reactome:REACT_83762 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS], Oryza sativa"
xref: Reactome:REACT_85039 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2], Dictyostelium discoideum"
xref: Reactome:REACT_85189 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2], Caenorhabditis elegans"
xref: Reactome:REACT_89739 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2], Canis familiaris"
xref: Reactome:REACT_89978 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS], Xenopus tropicalis"
xref: Reactome:REACT_91233 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS], Gallus gallus"
xref: Reactome:REACT_93144 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS], Drosophila melanogaster"
xref: Reactome:REACT_93220 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS], Arabidopsis thaliana"
xref: Reactome:REACT_96180 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS], Danio rerio"
xref: Reactome:REACT_96817 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2], Rattus norvegicus"
xref: Reactome:REACT_98673 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS], Bos taurus"
xref: Reactome:REACT_98846 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2], Sus scrofa"
xref: Reactome:REACT_99502 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS], Caenorhabditis elegans"
xref: RHEA:16600
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0003884
name: D-amino-acid oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a D-amino acid + H2O + O2 = a 2-oxo acid + NH3 + hydrogen peroxide." [EC:1.4.3.3]
subset: gosubset_prok
synonym: "D-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.3]
synonym: "L-amino acid:O2 oxidoreductase activity" EXACT [EC:1.4.3.3]
synonym: "new yellow enzyme" RELATED [EC:1.4.3.3]
xref: EC:1.4.3.3
xref: MetaCyc:D-AMINO-ACID-OXIDASE-RXN
xref: Reactome:REACT_106309 "glycine + O2 => glyoxylate + H2O2 + NH4+, Mus musculus"
xref: Reactome:REACT_113962 "glycine + O2 => glyoxylate + H2O2 + NH4+, Schizosaccharomyces pombe"
xref: Reactome:REACT_114219 "glycine + O2 => glyoxylate + H2O2 + NH4+, Drosophila melanogaster"
xref: Reactome:REACT_115360 "glycine + O2 => glyoxylate + H2O2 + NH4+, Mycobacterium tuberculosis"
xref: Reactome:REACT_115482 "glycine + O2 => glyoxylate + H2O2 + NH4+, Caenorhabditis elegans"
xref: Reactome:REACT_17049 "glycine + O2 => glyoxylate + H2O2 + NH4+, Homo sapiens"
xref: Reactome:REACT_31469 "glycine + O2 => glyoxylate + H2O2 + NH4+, Gallus gallus"
xref: Reactome:REACT_34652 "glycine + O2 => glyoxylate + H2O2 + NH4+, Danio rerio"
xref: Reactome:REACT_77556 "glycine + O2 => glyoxylate + H2O2 + NH4+, Bos taurus"
xref: Reactome:REACT_77723 "glycine + O2 => glyoxylate + H2O2 + NH4+, Taeniopygia guttata"
xref: Reactome:REACT_88459 "glycine + O2 => glyoxylate + H2O2 + NH4+, Canis familiaris"
xref: Reactome:REACT_88556 "glycine + O2 => glyoxylate + H2O2 + NH4+, Rattus norvegicus"
xref: Reactome:REACT_88963 "glycine + O2 => glyoxylate + H2O2 + NH4+, Sus scrofa"
xref: Reactome:REACT_93508 "glycine + O2 => glyoxylate + H2O2 + NH4+, Xenopus tropicalis"
xref: Reactome:REACT_93867 "glycine + O2 => glyoxylate + H2O2 + NH4+, Dictyostelium discoideum"
xref: RHEA:21819
is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

[Term]
id: GO:0003885
name: D-arabinono-1,4-lactone oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-arabinono-1,4-lactone + O(2) = dehydro-D-arabinono-1,4-lactone + H(2)O(2) + H(+)." [EC:1.1.3.37, RHEA:23759]
subset: gosubset_prok
synonym: "D-arabinono-1,4-lactone:oxygen oxidoreductase activity" EXACT [EC:1.1.3.37]
xref: EC:1.1.3.37
xref: KEGG:R02715
xref: MetaCyc:1.1.3.37-RXN
xref: RHEA:23759
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0003886
name: DNA (cytosine-5-)-methyltransferase activity
namespace: molecular_function
alt_id: GO:0008326
def: "Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine." [EC:2.1.1.37]
comment: Note that EC:2.1.1.73 was deleted from EC as the reaction is performed by DNA (cytosine-5-)-methyltransferase (EC:2.1.1.37).
subset: gosubset_prok
synonym: "cytosine 5-methyltransferase activity" EXACT [EC:2.1.1.37]
synonym: "cytosine DNA methylase activity" BROAD [EC:2.1.1.37]
synonym: "cytosine DNA methyltransferase activity" BROAD [EC:2.1.1.37]
synonym: "cytosine-specific DNA methyltransferase activity" EXACT [EC:2.1.1.37]
synonym: "deoxyribonucleic (cytosine-5-)-methyltransferase activity" EXACT [EC:2.1.1.37]
synonym: "deoxyribonucleic acid (cytosine-5-)-methyltransferase activity" EXACT [EC:2.1.1.37]
synonym: "deoxyribonucleic methylase activity" BROAD [EC:2.1.1.37]
synonym: "DNA 5-cytosine methylase activity" EXACT [EC:2.1.1.37]
synonym: "DNA cytosine C(5) methylase activity" EXACT [EC:2.1.1.37]
synonym: "DNA cytosine C5 methylase activity" EXACT [EC:2.1.1.37]
synonym: "DNA cytosine methylase activity" BROAD [EC:2.1.1.37]
synonym: "DNA-cytosine 5-methylase activity" EXACT [EC:2.1.1.37]
synonym: "DNA-cytosine methyltransferase activity" BROAD [EC:2.1.1.37]
synonym: "methylphosphotriester-DNA methyltransferase activity" RELATED [EC:2.1.1.37]
synonym: "modification methylase activity" RELATED [EC:2.1.1.37]
synonym: "restriction-modification system activity" RELATED [EC:2.1.1.37]
synonym: "S-adenosyl-L-methionine:DNA (cytosine-5-)-methyltransferase activity" EXACT [EC:2.1.1.37]
synonym: "site-specific DNA-methyltransferase (cytosine-specific) activity" NARROW [EC:2.1.1.37]
synonym: "type II DNA methylase activity" RELATED [EC:2.1.1.37]
xref: EC:2.1.1.37
xref: MetaCyc:2.1.1.73-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
is_a: GO:0009008 ! DNA-methyltransferase activity
relationship: part_of GO:0090116 ! C-5 methylation of cytosine

[Term]
id: GO:0003887
name: DNA-directed DNA polymerase activity
namespace: molecular_function
alt_id: GO:0003888
alt_id: GO:0003889
alt_id: GO:0003890
alt_id: GO:0003891
alt_id: GO:0003893
alt_id: GO:0003894
alt_id: GO:0003895
alt_id: GO:0008723
alt_id: GO:0015999
alt_id: GO:0016000
alt_id: GO:0016448
alt_id: GO:0016449
alt_id: GO:0016450
alt_id: GO:0016451
alt_id: GO:0016452
alt_id: GO:0019984
def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684]
subset: gosubset_prok
synonym: "alpha DNA polymerase activity" NARROW []
synonym: "beta DNA polymerase activity" NARROW []
synonym: "delta DNA polymerase activity" NARROW []
synonym: "deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [EC:2.7.7.7]
synonym: "deoxyribonucleic acid duplicase activity" EXACT [EC:2.7.7.7]
synonym: "deoxyribonucleic duplicase activity" EXACT [EC:2.7.7.7]
synonym: "deoxyribonucleic polymerase I" NARROW [EC:2.7.7.7]
synonym: "DNA duplicase activity" EXACT [EC:2.7.7.7]
synonym: "DNA nucleotidyltransferase (DNA-directed) activity" EXACT [EC:2.7.7.7]
synonym: "DNA polymerase alpha" NARROW [EC:2.7.7.7]
synonym: "DNA polymerase beta" NARROW [EC:2.7.7.7]
synonym: "DNA polymerase gamma" NARROW [EC:2.7.7.7]
synonym: "DNA polymerase I" NARROW [EC:2.7.7.7]
synonym: "DNA polymerase II" NARROW [EC:2.7.7.7]
synonym: "DNA polymerase III" NARROW [EC:2.7.7.7]
synonym: "DNA polymerase V activity" NARROW []
synonym: "DNA replicase activity" EXACT [EC:2.7.7.7]
synonym: "DNA-dependent DNA polymerase activity" EXACT [EC:2.7.7.7]
synonym: "duplicase" BROAD [EC:2.7.7.7]
synonym: "epsilon DNA polymerase activity" NARROW []
synonym: "eta DNA polymerase activity" NARROW []
synonym: "gamma DNA-directed DNA polymerase activity" NARROW []
synonym: "iota DNA polymerase activity" NARROW []
synonym: "kappa DNA polymerase activity" NARROW []
synonym: "Klenow fragment" NARROW [EC:2.7.7.7]
synonym: "lambda DNA polymerase activity" NARROW []
synonym: "mu DNA polymerase activity" NARROW []
synonym: "nu DNA polymerase activity" NARROW []
synonym: "sequenase" RELATED [EC:2.7.7.7]
synonym: "sigma DNA polymerase activity" NARROW []
synonym: "Taq DNA polymerase" NARROW [EC:2.7.7.7]
synonym: "Taq Pol I" NARROW [EC:2.7.7.7]
synonym: "Tca DNA polymerase" NARROW [EC:2.7.7.7]
synonym: "theta DNA polymerase activity" NARROW []
synonym: "zeta DNA polymerase activity" NARROW []
xref: EC:2.7.7.7
xref: MetaCyc:DNA-DIRECTED-DNA-POLYMERASE-RXN
xref: Reactome:REACT_101168 "Misinsertion of bases opposite to the lesion by HREV1, Drosophila melanogaster"
xref: Reactome:REACT_101456 "Elongation by HREV1 protein, Arabidopsis thaliana"
xref: Reactome:REACT_101578 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin, Schizosaccharomyces pombe"
xref: Reactome:REACT_102164 "DNA strand displacement synthesis, Arabidopsis thaliana"
xref: Reactome:REACT_1024 "Formation of Okazaki fragments, Homo sapiens"
xref: Reactome:REACT_102850 "Elongation by Pol eta, Sus scrofa"
xref: Reactome:REACT_102905 "Resynthesis of excised residue, Mus musculus"
xref: Reactome:REACT_103072 "POL Beta mediated incorporation of the first replacement nucleotide, Taeniopygia guttata"
xref: Reactome:REACT_103285 "Elongation by Pol zeta complex, Sus scrofa"
xref: Reactome:REACT_103439 "Misinsertion of bases opposite to the lesion by HREV1, Taeniopygia guttata"
xref: Reactome:REACT_103520 "Elongation by Pol zeta complex, Mus musculus"
xref: Reactome:REACT_103531 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin, Arabidopsis thaliana"
xref: Reactome:REACT_104153 "Formation of Okazaki fragments, Arabidopsis thaliana"
xref: Reactome:REACT_104851 "Elongation by HREV1 protein, Drosophila melanogaster"
xref: Reactome:REACT_104914 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Rattus norvegicus"
xref: Reactome:REACT_104973 "Elongation by Pol eta, Arabidopsis thaliana"
xref: Reactome:REACT_105070 "Insertion of correct bases opposite to the lesion by Pol eta, Saccharomyces cerevisiae"
xref: Reactome:REACT_105462 "Formation of C-strand Okazaki fragments, Sus scrofa"
xref: Reactome:REACT_105659 "Repair synthesis of patch ~27-30 bases long by DNA Pol Delta, Danio rerio"
xref: Reactome:REACT_105733 "Elongation by HREV1 protein, Canis familiaris"
xref: Reactome:REACT_105794 "Insertion of correct bases opposite to the lesion by Pol eta, Arabidopsis thaliana"
xref: Reactome:REACT_105961 "Repair synthesis of ~27-30 bases long patch by DNA Pol Epsilon, Bos taurus"
xref: Reactome:REACT_106002 "Resynthesis of excised residue, Rattus norvegicus"
xref: Reactome:REACT_106057 "Insertion of correct bases opposite to the lesion by Pol eta, Drosophila melanogaster"
xref: Reactome:REACT_106334 "Repair synthesis for gap-filling by DNA pol delta in TC-NER, Canis familiaris"
xref: Reactome:REACT_106776 "Elongation by HREV1 protein, Caenorhabditis elegans"
xref: Reactome:REACT_106994 "Formation of C-strand Okazaki fragments, Schizosaccharomyces pombe"
xref: Reactome:REACT_107125 "Elongation by HREV1 protein, Rattus norvegicus"
xref: Reactome:REACT_107358 "Repair synthesis of ~27-30 bases long patch by DNA Pol Epsilon, Danio rerio"
xref: Reactome:REACT_107480 "Elongation by HREV1 protein, Schizosaccharomyces pombe"
xref: Reactome:REACT_107781 "Misinsertion of bases opposite to the lesion by HREV1, Rattus norvegicus"
xref: Reactome:REACT_107879 "Repair synthesis for gap-filling by DNA pol epsilon in TC-NER, Canis familiaris"
xref: Reactome:REACT_107930 "Formation of Okazaki fragments, Mus musculus"
xref: Reactome:REACT_108241 "Elongation by HREV1 protein, Xenopus tropicalis"
xref: Reactome:REACT_108640 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin, Drosophila melanogaster"
xref: Reactome:REACT_108802 "Elongation by Pol eta, Rattus norvegicus"
xref: Reactome:REACT_109069 "Formation of Okazaki fragments, Oryza sativa"
xref: Reactome:REACT_109329 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin, Bos taurus"
xref: Reactome:REACT_109542 "Repair synthesis for gap-filling by DNA pol epsilon in TC-NER, Xenopus tropicalis"
xref: Reactome:REACT_109593 "Formation of C-strand Okazaki fragments, Mus musculus"
xref: Reactome:REACT_109749 "Repair synthesis of patch ~27-30 bases long by DNA Pol Delta, Rattus norvegicus"
xref: Reactome:REACT_109858 "Insertion of correct bases opposite to the lesion by Pol eta, Bos taurus"
xref: Reactome:REACT_109873 "Repair synthesis for gap-filling by DNA pol delta in TC-NER, Xenopus tropicalis"
xref: Reactome:REACT_109947 "Misinsertion of bases opposite to the lesion by HREV1, Xenopus tropicalis"
xref: Reactome:REACT_110252 "Formation of C-strand Okazaki fragments, Canis familiaris"
xref: Reactome:REACT_112231 "Elongation by Pol zeta complex, Xenopus tropicalis"
xref: Reactome:REACT_112289 "Elongation by Pol zeta complex, Taeniopygia guttata"
xref: Reactome:REACT_112468 "Elongation by Pol zeta complex, Dictyostelium discoideum"
xref: Reactome:REACT_1196 "Repair synthesis for gap-filling by DNA pol delta in TC-NER, Homo sapiens"
xref: Reactome:REACT_1324 "Elongation by Pol zeta complex, Homo sapiens"
xref: Reactome:REACT_1479 "Elongation by Pol eta, Homo sapiens"
xref: Reactome:REACT_2016 "Insertion of correct bases opposite to the lesion by Pol eta, Homo sapiens"
xref: Reactome:REACT_2214 "Misinsertion of bases opposite to the lesion by HREV1, Homo sapiens"
xref: Reactome:REACT_2224 "POL Beta mediated incorporation of the first replacement nucleotide, Homo sapiens"
xref: Reactome:REACT_28103 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Schizosaccharomyces pombe"
xref: Reactome:REACT_28619 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin, Rattus norvegicus"
xref: Reactome:REACT_28865 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin, Dictyostelium discoideum"
xref: Reactome:REACT_29011 "Elongation by Pol zeta complex, Gallus gallus"
xref: Reactome:REACT_29030 "Formation of C-strand Okazaki fragments, Danio rerio"
xref: Reactome:REACT_292 "Resynthesis of excised residue, Homo sapiens"
xref: Reactome:REACT_29783 "Insertion of correct bases opposite to the lesion by Pol eta, Gallus gallus"
xref: Reactome:REACT_31346 "Elongation by Pol eta, Drosophila melanogaster"
xref: Reactome:REACT_31460 "Misinsertion of bases opposite to the lesion by HREV1, Oryza sativa"
xref: Reactome:REACT_31614 "POL Beta mediated incorporation of the first replacement nucleotide, Danio rerio"
xref: Reactome:REACT_31809 "POL Beta mediated incorporation of the first replacement nucleotide, Mus musculus"
xref: Reactome:REACT_32473 "Elongation by Pol eta, Gallus gallus"
xref: Reactome:REACT_32478 "Formation of Okazaki fragments, Xenopus tropicalis"
xref: Reactome:REACT_32689 "Misinsertion of bases opposite to the lesion by HREV1, Gallus gallus"
xref: Reactome:REACT_32853 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin, Canis familiaris"
xref: Reactome:REACT_33072 "Insertion of correct bases opposite to the lesion by Pol eta, Taeniopygia guttata"
xref: Reactome:REACT_33294 "Insertion of correct bases opposite to the lesion by Pol eta, Sus scrofa"
xref: Reactome:REACT_33524 "Repair synthesis of patch ~27-30 bases long by DNA Pol Delta, Canis familiaris"
xref: Reactome:REACT_34369 "Elongation by Pol eta, Caenorhabditis elegans"
xref: Reactome:REACT_34392 "Misinsertion of bases opposite to the lesion by HREV1, Sus scrofa"
xref: Reactome:REACT_34531 "DNA strand displacement synthesis, Danio rerio"
xref: Reactome:REACT_353 "Repair synthesis of ~27-30 bases long patch by DNA Pol Epsilon, Homo sapiens"
xref: Reactome:REACT_36881 "Repair synthesis of ~27-30 bases long patch by DNA Pol Epsilon, Canis familiaris"
xref: Reactome:REACT_41 "DNA strand displacement synthesis, Homo sapiens"
xref: Reactome:REACT_465 "Repair synthesis of patch ~27-30 bases long by DNA Pol Delta, Homo sapiens"
xref: Reactome:REACT_54850 "POL Beta mediated incorporation of the first replacement nucleotide, Canis familiaris"
xref: Reactome:REACT_677 "Repair synthesis for gap-filling by DNA pol epsilon in TC-NER, Homo sapiens"
xref: Reactome:REACT_68438 "Formation of Okazaki fragments, Schizosaccharomyces pombe"
xref: Reactome:REACT_77128 "Formation of C-strand Okazaki fragments, Oryza sativa"
xref: Reactome:REACT_77463 "Misinsertion of bases opposite to the lesion by HREV1, Caenorhabditis elegans"
xref: Reactome:REACT_77925 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Plasmodium falciparum"
xref: Reactome:REACT_78145 "Resynthesis of excised residue, Canis familiaris"
xref: Reactome:REACT_78146 "Repair synthesis for gap-filling by DNA pol epsilon in TC-NER, Taeniopygia guttata"
xref: Reactome:REACT_78405 "Formation of Okazaki fragments, Danio rerio"
xref: Reactome:REACT_78413 "Misinsertion of bases opposite to the lesion by HREV1, Schizosaccharomyces pombe"
xref: Reactome:REACT_78425 "DNA strand displacement synthesis, Xenopus tropicalis"
xref: Reactome:REACT_78678 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin, Mus musculus"
xref: Reactome:REACT_78735 "Repair synthesis of ~27-30 bases long patch by DNA Pol Epsilon, Gallus gallus"
xref: Reactome:REACT_78796 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin, Caenorhabditis elegans"
xref: Reactome:REACT_79308 "Elongation by Pol eta, Taeniopygia guttata"
xref: Reactome:REACT_79568 "Elongation by HREV1 protein, Mycobacterium tuberculosis"
xref: Reactome:REACT_79756 "Resynthesis of excised residue, Bos taurus"
xref: Reactome:REACT_79977 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Saccharomyces cerevisiae"
xref: Reactome:REACT_80037 "Repair synthesis for gap-filling by DNA pol epsilon in TC-NER, Danio rerio"
xref: Reactome:REACT_8004 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Homo sapiens"
xref: Reactome:REACT_80054 "Elongation by Pol eta, Bos taurus"
xref: Reactome:REACT_80171 "Repair synthesis of ~27-30 bases long patch by DNA Pol Epsilon, Taeniopygia guttata"
xref: Reactome:REACT_8029 "Formation of C-strand Okazaki fragments, Homo sapiens"
xref: Reactome:REACT_80471 "Repair synthesis of patch ~27-30 bases long by DNA Pol Delta, Mus musculus"
xref: Reactome:REACT_80487 "Elongation by Pol eta, Schizosaccharomyces pombe"
xref: Reactome:REACT_80495 "Insertion of correct bases opposite to the lesion by Pol eta, Mus musculus"
xref: Reactome:REACT_80499 "Elongation by Pol eta, Mycobacterium tuberculosis"
xref: Reactome:REACT_80513 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Dictyostelium discoideum"
xref: Reactome:REACT_80712 "Misinsertion of bases opposite to the lesion by HREV1, Mus musculus"
xref: Reactome:REACT_80802 "Resynthesis of excised residue, Dictyostelium discoideum"
xref: Reactome:REACT_81020 "Insertion of correct bases opposite to the lesion by Pol eta, Caenorhabditis elegans"
xref: Reactome:REACT_81188 "Repair synthesis for gap-filling by DNA pol epsilon in TC-NER, Gallus gallus"
xref: Reactome:REACT_81625 "DNA strand displacement synthesis, Oryza sativa"
xref: Reactome:REACT_81807 "Insertion of correct bases opposite to the lesion by Pol eta, Mycobacterium tuberculosis"
xref: Reactome:REACT_81927 "Resynthesis of excised residue, Danio rerio"
xref: Reactome:REACT_81968 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Sus scrofa"
xref: Reactome:REACT_82001 "Misinsertion of bases opposite to the lesion by HREV1, Arabidopsis thaliana"
xref: Reactome:REACT_82035 "Misinsertion of bases opposite to the lesion by HREV1, Canis familiaris"
xref: Reactome:REACT_82077 "Insertion of correct bases opposite to the lesion by Pol eta, Danio rerio"
xref: Reactome:REACT_82208 "Elongation by HREV1 protein, Sus scrofa"
xref: Reactome:REACT_82246 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Drosophila melanogaster"
xref: Reactome:REACT_82557 "Repair synthesis of ~27-30 bases long patch by DNA Pol Epsilon, Mus musculus"
xref: Reactome:REACT_82934 "Elongation by Pol zeta complex, Rattus norvegicus"
xref: Reactome:REACT_83390 "Elongation by HREV1 protein, Gallus gallus"
xref: Reactome:REACT_83447 "Elongation by Pol zeta complex, Canis familiaris"
xref: Reactome:REACT_83674 "Elongation by Pol eta, Saccharomyces cerevisiae"
xref: Reactome:REACT_83763 "Elongation by Pol eta, Mus musculus"
xref: Reactome:REACT_83918 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin, Sus scrofa"
xref: Reactome:REACT_84028 "Repair synthesis of ~27-30 bases long patch by DNA Pol Epsilon, Rattus norvegicus"
xref: Reactome:REACT_84123 "DNA strand displacement synthesis, Mus musculus"
xref: Reactome:REACT_84407 "Elongation by HREV1 protein, Saccharomyces cerevisiae"
xref: Reactome:REACT_84633 "Formation of Okazaki fragments, Canis familiaris"
xref: Reactome:REACT_84853 "Misinsertion of bases opposite to the lesion by HREV1, Danio rerio"
xref: Reactome:REACT_84864 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Mus musculus"
xref: Reactome:REACT_85325 "Formation of Okazaki fragments, Bos taurus"
xref: Reactome:REACT_85611 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin, Saccharomyces cerevisiae"
xref: Reactome:REACT_86134 "Insertion of correct bases opposite to the lesion by Pol eta, Schizosaccharomyces pombe"
xref: Reactome:REACT_86652 "Elongation by HREV1 protein, Mus musculus"
xref: Reactome:REACT_867 "Elongation by HREV1 protein, Homo sapiens"
xref: Reactome:REACT_86753 "Repair synthesis of patch ~27-30 bases long by DNA Pol Delta, Xenopus tropicalis"
xref: Reactome:REACT_87271 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Xenopus tropicalis"
xref: Reactome:REACT_87439 "DNA strand displacement synthesis, Bos taurus"
xref: Reactome:REACT_87801 "Misinsertion of bases opposite to the lesion by HREV1, Mycobacterium tuberculosis"
xref: Reactome:REACT_88067 "Elongation by Pol zeta complex, Bos taurus"
xref: Reactome:REACT_88473 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin, Oryza sativa"
xref: Reactome:REACT_88663 "Insertion of correct bases opposite to the lesion by Pol eta, Oryza sativa"
xref: Reactome:REACT_88811 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Danio rerio"
xref: Reactome:REACT_88997 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin, Plasmodium falciparum"
xref: Reactome:REACT_89118 "Repair synthesis for gap-filling by DNA pol epsilon in TC-NER, Mus musculus"
xref: Reactome:REACT_89129 "DNA strand displacement synthesis, Canis familiaris"
xref: Reactome:REACT_89399 "Formation of Okazaki fragments, Rattus norvegicus"
xref: Reactome:REACT_89782 "POL Beta mediated incorporation of the first replacement nucleotide, Rattus norvegicus"
xref: Reactome:REACT_89896 "Formation of C-strand Okazaki fragments, Bos taurus"
xref: Reactome:REACT_8992 "Synthesis of full-length duplex viral DNA with a discontinuous plus strand, Homo sapiens"
xref: Reactome:REACT_90310 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin, Xenopus tropicalis"
xref: Reactome:REACT_90511 "Misinsertion of bases opposite to the lesion by HREV1, Saccharomyces cerevisiae"
xref: Reactome:REACT_90564 "DNA strand displacement synthesis, Sus scrofa"
xref: Reactome:REACT_90691 "Insertion of correct bases opposite to the lesion by Pol eta, Canis familiaris"
xref: Reactome:REACT_9075 "3' PPT-primed initiation of plus-strand DNA synthesis, Homo sapiens"
xref: Reactome:REACT_91 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin, Homo sapiens"
xref: Reactome:REACT_91123 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin, Danio rerio"
xref: Reactome:REACT_91124 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Caenorhabditis elegans"
xref: Reactome:REACT_91218 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Oryza sativa"
xref: Reactome:REACT_91365 "Formation of C-strand Okazaki fragments, Rattus norvegicus"
xref: Reactome:REACT_91536 "Elongation by Pol eta, Oryza sativa"
xref: Reactome:REACT_91619 "Elongation by Pol eta, Canis familiaris"
xref: Reactome:REACT_91873 "POL Beta mediated incorporation of the first replacement nucleotide, Xenopus tropicalis"
xref: Reactome:REACT_91890 "Repair synthesis for gap-filling by DNA pol delta in TC-NER, Rattus norvegicus"
xref: Reactome:REACT_92243 "Repair synthesis for gap-filling by DNA pol epsilon in TC-NER, Rattus norvegicus"
xref: Reactome:REACT_92358 "POL Beta mediated incorporation of the first replacement nucleotide, Sus scrofa"
xref: Reactome:REACT_92410 "POL Beta mediated incorporation of the first replacement nucleotide, Dictyostelium discoideum"
xref: Reactome:REACT_92575 "Repair synthesis for gap-filling by DNA pol epsilon in TC-NER, Bos taurus"
xref: Reactome:REACT_92627 "Elongation by Pol eta, Danio rerio"
xref: Reactome:REACT_92680 "Elongation by Pol zeta complex, Arabidopsis thaliana"
xref: Reactome:REACT_93171 "Repair synthesis for gap-filling by DNA pol delta in TC-NER, Mus musculus"
xref: Reactome:REACT_93535 "Formation of C-strand Okazaki fragments, Arabidopsis thaliana"
xref: Reactome:REACT_93828 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Canis familiaris"
xref: Reactome:REACT_94081 "Elongation by Pol zeta complex, Drosophila melanogaster"
xref: Reactome:REACT_94622 "POL Beta mediated incorporation of the first replacement nucleotide, Bos taurus"
xref: Reactome:REACT_95001 "Formation of Okazaki fragments, Sus scrofa"
xref: Reactome:REACT_95443 "DNA strand displacement synthesis, Rattus norvegicus"
xref: Reactome:REACT_95853 "Resynthesis of excised residue, Xenopus tropicalis"
xref: Reactome:REACT_96429 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Arabidopsis thaliana"
xref: Reactome:REACT_96549 "Repair synthesis for gap-filling by DNA pol delta in TC-NER, Bos taurus"
xref: Reactome:REACT_97064 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Bos taurus"
xref: Reactome:REACT_97260 "Formation of C-strand Okazaki fragments, Xenopus tropicalis"
xref: Reactome:REACT_97598 "Elongation by Pol zeta complex, Schizosaccharomyces pombe"
xref: Reactome:REACT_97861 "Elongation by HREV1 protein, Taeniopygia guttata"
xref: Reactome:REACT_97874 "Elongation by HREV1 protein, Oryza sativa"
xref: Reactome:REACT_97969 "Insertion of correct bases opposite to the lesion by Pol eta, Rattus norvegicus"
xref: Reactome:REACT_97975 "Repair synthesis for gap-filling by DNA pol delta in TC-NER, Danio rerio"
xref: Reactome:REACT_98393 "Repair synthesis of patch ~27-30 bases long by DNA Pol Delta, Bos taurus"
xref: Reactome:REACT_98499 "Repair synthesis of ~27-30 bases long patch by DNA Pol Epsilon, Xenopus tropicalis"
xref: Reactome:REACT_98529 "Elongation by HREV1 protein, Danio rerio"
xref: Reactome:REACT_99265 "Elongation by Pol zeta complex, Danio rerio"
is_a: GO:0034061 ! DNA polymerase activity

[Term]
id: GO:0003892
name: obsolete proliferating cell nuclear antigen
namespace: molecular_function
alt_id: GO:0005661
def: "OBSOLETE. A nuclear protein that associates as a trimer and then interacts with delta DNA polymerase and epsilon DNA polymerase, acting as an auxiliary factor for DNA replication and DNA repair." [ISBN:0123668387]
comment: This term was made obsolete because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity.
synonym: "PCNA" EXACT []
synonym: "proliferating cell nuclear antigen" EXACT []
is_obsolete: true

[Term]
id: GO:0003896
name: DNA primase activity
namespace: molecular_function
alt_id: GO:0003897
alt_id: GO:0003898
def: "Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases." [GOC:mah, GOC:mcc, ISBN:0716720094, PMID:26184436]
subset: gosubset_prok
xref: EC:2.7.7.-
is_a: GO:0003899 ! DNA-directed RNA polymerase activity
relationship: part_of GO:0006269 ! DNA replication, synthesis of RNA primer

[Term]
id: GO:0003899
name: DNA-directed RNA polymerase activity
namespace: molecular_function
alt_id: GO:0000129
def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
subset: gosubset_prok
synonym: "C ribonucleic acid formation factors" RELATED [EC:2.7.7.6]
synonym: "C RNA formation factors" RELATED [EC:2.7.7.6]
synonym: "deoxyribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [EC:2.7.7.6]
synonym: "DNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [EC:2.7.7.6]
synonym: "DNA-dependent RNA nucleotidyltransferase activity" EXACT [EC:2.7.7.6]
synonym: "DNA-dependent RNA polymerase activity" EXACT [EC:2.7.7.6]
synonym: "DNA-directed RNA polymerase I activity" NARROW []
synonym: "DNA-directed RNA polymerase II activity" NARROW []
synonym: "DNA-directed RNA polymerase III activity" NARROW []
synonym: "nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed) activity" EXACT [EC:2.7.7.6]
synonym: "RNA nucleotidyltransferase (DNA-directed) activity" EXACT [EC:2.7.7.6]
synonym: "RNA polymerase I activity" NARROW [EC:2.7.7.6]
synonym: "RNA polymerase II activity" NARROW [EC:2.7.7.6]
synonym: "RNA polymerase III activity" NARROW [EC:2.7.7.6]
synonym: "transcriptase" BROAD [EC:2.7.7.6]
xref: EC:2.7.7.6
xref: MetaCyc:DNA-DIRECTED-RNA-POLYMERASE-RXN
xref: Reactome:REACT_100344 "Addition of Nucleotides 5 through 9 on the growing Transcript, Drosophila melanogaster"
xref: Reactome:REACT_100410 "Addition of nucleotides between position +11 and +30, Bos taurus"
xref: Reactome:REACT_101111 "Addition of the third nucleotide on the nascent transcript, Saccharomyces cerevisiae"
xref: Reactome:REACT_101858 "Elongation of pre-rRNA transcript, Taeniopygia guttata"
xref: Reactome:REACT_101953 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Oryza sativa"
xref: Reactome:REACT_101994 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Xenopus tropicalis"
xref: Reactome:REACT_102121 "Addition of the third nucleotide on the nascent transcript, Rattus norvegicus"
xref: Reactome:REACT_102441 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Gallus gallus"
xref: Reactome:REACT_102466 "Addition of nucleotides between position +11 and +30, Rattus norvegicus"
xref: Reactome:REACT_102706 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition, Rattus norvegicus"
xref: Reactome:REACT_102769 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin, Schizosaccharomyces pombe"
xref: Reactome:REACT_102802 "Pol II mediated transcription of microRNA genes, Saccharomyces cerevisiae"
xref: Reactome:REACT_102951 "Elongation of pre-rRNA transcript, Drosophila melanogaster"
xref: Reactome:REACT_103006 "Elongation of pre-rRNA transcript, Rattus norvegicus"
xref: Reactome:REACT_103501 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Xenopus tropicalis"
xref: Reactome:REACT_103871 "Addition of nucleotides between position +11 and +30, Gallus gallus"
xref: Reactome:REACT_103959 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Rattus norvegicus"
xref: Reactome:REACT_104171 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Danio rerio"
xref: Reactome:REACT_104334 "Addition of nucleotides between position +11 and +30, Canis familiaris"
xref: Reactome:REACT_104618 "Pol II mediated transcription of microRNA genes, Oryza sativa"
xref: Reactome:REACT_105022 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition, Drosophila melanogaster"
xref: Reactome:REACT_105177 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Mus musculus"
xref: Reactome:REACT_105539 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition, Gallus gallus"
xref: Reactome:REACT_105890 "Pol II mediated transcription of microRNA genes, Taeniopygia guttata"
xref: Reactome:REACT_106497 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin, Plasmodium falciparum"
xref: Reactome:REACT_106762 "Addition of Nucleotides 5 through 9 on the growing Transcript, Mus musculus"
xref: Reactome:REACT_106790 "Addition of Nucleotides 5 through 9 on the growing Transcript, Danio rerio"
xref: Reactome:REACT_108159 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Dictyostelium discoideum"
xref: Reactome:REACT_1082 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition, Homo sapiens"
xref: Reactome:REACT_108279 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Rattus norvegicus"
xref: Reactome:REACT_108323 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Plasmodium falciparum"
xref: Reactome:REACT_108648 "Addition of the third nucleotide on the nascent transcript, Arabidopsis thaliana"
xref: Reactome:REACT_109090 "Addition of nucleotides between position +11 and +30, Saccharomyces cerevisiae"
xref: Reactome:REACT_109161 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Arabidopsis thaliana"
xref: Reactome:REACT_110305 "Pol II mediated transcription of microRNA genes, Danio rerio"
xref: Reactome:REACT_110458 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition, Canis familiaris"
xref: Reactome:REACT_110741 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Saccharomyces cerevisiae"
xref: Reactome:REACT_112737 "Addition of Nucleotides 5 through 9 on the growing Transcript, Gallus gallus"
xref: Reactome:REACT_112968 "Elongation of pre-rRNA transcript, Oryza sativa"
xref: Reactome:REACT_113943 "Elongation of pre-rRNA transcript, Gallus gallus"
xref: Reactome:REACT_12505 "Pol II mediated transcription of microRNA genes, Homo sapiens"
xref: Reactome:REACT_1611 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin, Homo sapiens"
xref: Reactome:REACT_1817 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Homo sapiens"
xref: Reactome:REACT_209 "Addition of nucleotides between position +11 and +30, Homo sapiens"
xref: Reactome:REACT_28131 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Drosophila melanogaster"
xref: Reactome:REACT_28303 "Addition of nucleotides between position +11 and +30, Arabidopsis thaliana"
xref: Reactome:REACT_28467 "Pol II mediated transcription of microRNA genes, Caenorhabditis elegans"
xref: Reactome:REACT_28810 "Addition of the third nucleotide on the nascent transcript, Oryza sativa"
xref: Reactome:REACT_28970 "Addition of nucleotides between position +11 and +30, Oryza sativa"
xref: Reactome:REACT_29155 "Addition of the third nucleotide on the nascent transcript, Drosophila melanogaster"
xref: Reactome:REACT_29681 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition, Oryza sativa"
xref: Reactome:REACT_29818 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Oryza sativa"
xref: Reactome:REACT_30335 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition, Caenorhabditis elegans"
xref: Reactome:REACT_31554 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Schizosaccharomyces pombe"
xref: Reactome:REACT_31831 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin, Caenorhabditis elegans"
xref: Reactome:REACT_32533 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Caenorhabditis elegans"
xref: Reactome:REACT_32905 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin, Arabidopsis thaliana"
xref: Reactome:REACT_34518 "Elongation of pre-rRNA transcript, Sus scrofa"
xref: Reactome:REACT_40 "Addition of the third nucleotide on the nascent transcript, Homo sapiens"
xref: Reactome:REACT_581 "Addition of Nucleotides 5 through 9 on the growing Transcript, Homo sapiens"
xref: Reactome:REACT_6172 "Addition of nucleotides 5 through 9 on the growing HIV-1 transcript, Homo sapiens"
xref: Reactome:REACT_6184 "Addition of the fourth nucleotide on the nascent HIV-1 transcript: Second Transition, Homo sapiens"
xref: Reactome:REACT_6208 "Addition of nucleotides 10 and 11 on the growing HIV-1 transcript: Third Transition, Homo sapiens"
xref: Reactome:REACT_6240 "Addition of nucleotides between position +11 and +30 on HIV-1 transcript, Homo sapiens"
xref: Reactome:REACT_6325 "Addition of the third nucleotide on the nascent HIV-1 transcript, Homo sapiens"
xref: Reactome:REACT_77161 "Pol II mediated transcription of microRNA genes, Gallus gallus"
xref: Reactome:REACT_77417 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition, Danio rerio"
xref: Reactome:REACT_77879 "Addition of nucleotides between position +11 and +30, Drosophila melanogaster"
xref: Reactome:REACT_78158 "Elongation of pre-rRNA transcript, Bos taurus"
xref: Reactome:REACT_79759 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Mus musculus"
xref: Reactome:REACT_7998 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Homo sapiens"
xref: Reactome:REACT_80162 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition, Xenopus tropicalis"
xref: Reactome:REACT_80268 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin, Danio rerio"
xref: Reactome:REACT_80325 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Danio rerio"
xref: Reactome:REACT_80396 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin, Mus musculus"
xref: Reactome:REACT_80464 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin, Dictyostelium discoideum"
xref: Reactome:REACT_80532 "Addition of the third nucleotide on the nascent transcript, Gallus gallus"
xref: Reactome:REACT_80605 "Addition of the third nucleotide on the nascent transcript, Mus musculus"
xref: Reactome:REACT_80768 "Elongation of pre-rRNA transcript, Schizosaccharomyces pombe"
xref: Reactome:REACT_80999 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Schizosaccharomyces pombe"
xref: Reactome:REACT_81126 "Addition of the third nucleotide on the nascent transcript, Schizosaccharomyces pombe"
xref: Reactome:REACT_81250 "Elongation of pre-rRNA transcript, Canis familiaris"
xref: Reactome:REACT_81257 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition, Schizosaccharomyces pombe"
xref: Reactome:REACT_82798 "Addition of nucleotides between position +11 and +30, Schizosaccharomyces pombe"
xref: Reactome:REACT_83185 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin, Canis familiaris"
xref: Reactome:REACT_83805 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Drosophila melanogaster"
xref: Reactome:REACT_84137 "Pol II mediated transcription of microRNA genes, Plasmodium falciparum"
xref: Reactome:REACT_84172 "Pol II mediated transcription of microRNA genes, Xenopus tropicalis"
xref: Reactome:REACT_85303 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Arabidopsis thaliana"
xref: Reactome:REACT_85444 "Pol II mediated transcription of microRNA genes, Bos taurus"
xref: Reactome:REACT_86290 "Elongation of pre-rRNA transcript, Mus musculus"
xref: Reactome:REACT_86701 "Pol II mediated transcription of microRNA genes, Dictyostelium discoideum"
xref: Reactome:REACT_86831 "Elongation of pre-rRNA transcript, Xenopus tropicalis"
xref: Reactome:REACT_87150 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin, Rattus norvegicus"
xref: Reactome:REACT_872 "Elongation of pre-rRNA transcript, Homo sapiens"
xref: Reactome:REACT_87708 "Addition of nucleotides between position +11 and +30, Mus musculus"
xref: Reactome:REACT_88237 "Addition of nucleotides between position +11 and +30, Xenopus tropicalis"
xref: Reactome:REACT_88362 "Addition of the third nucleotide on the nascent transcript, Caenorhabditis elegans"
xref: Reactome:REACT_88577 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition, Arabidopsis thaliana"
xref: Reactome:REACT_89363 "Addition of the third nucleotide on the nascent transcript, Xenopus tropicalis"
xref: Reactome:REACT_89527 "Addition of Nucleotides 5 through 9 on the growing Transcript, Rattus norvegicus"
xref: Reactome:REACT_89539 "Pol II mediated transcription of microRNA genes, Arabidopsis thaliana"
xref: Reactome:REACT_90076 "Addition of nucleotides between position +11 and +30, Caenorhabditis elegans"
xref: Reactome:REACT_90432 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Caenorhabditis elegans"
xref: Reactome:REACT_90456 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin, Xenopus tropicalis"
xref: Reactome:REACT_91185 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Bos taurus"
xref: Reactome:REACT_91186 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin, Drosophila melanogaster"
xref: Reactome:REACT_91701 "Pol II mediated transcription of microRNA genes, Drosophila melanogaster"
xref: Reactome:REACT_91945 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin, Saccharomyces cerevisiae"
xref: Reactome:REACT_93006 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin, Bos taurus"
xref: Reactome:REACT_93214 "Addition of Nucleotides 5 through 9 on the growing Transcript, Xenopus tropicalis"
xref: Reactome:REACT_93674 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Dictyostelium discoideum"
xref: Reactome:REACT_94323 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Canis familiaris"
xref: Reactome:REACT_95240 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition, Saccharomyces cerevisiae"
xref: Reactome:REACT_95273 "Pol II mediated transcription of microRNA genes, Canis familiaris"
xref: Reactome:REACT_95718 "Pol II mediated transcription of microRNA genes, Rattus norvegicus"
xref: Reactome:REACT_95942 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Saccharomyces cerevisiae"
xref: Reactome:REACT_96380 "Addition of nucleotides between position +11 and +30, Danio rerio"
xref: Reactome:REACT_97333 "Pol II mediated transcription of microRNA genes, Schizosaccharomyces pombe"
xref: Reactome:REACT_97557 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition, Bos taurus"
xref: Reactome:REACT_97977 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition, Mus musculus"
xref: Reactome:REACT_98273 "Addition of the third nucleotide on the nascent transcript, Dictyostelium discoideum"
xref: Reactome:REACT_98842 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition, Dictyostelium discoideum"
xref: Reactome:REACT_98844 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin, Oryza sativa"
xref: Reactome:REACT_98898 "Pol II mediated transcription of microRNA genes, Mus musculus"
xref: Reactome:REACT_99037 "Elongation of pre-rRNA transcript, Caenorhabditis elegans"
xref: Reactome:REACT_99120 "Addition of the third nucleotide on the nascent transcript, Danio rerio"
xref: Reactome:REACT_99215 "Addition of nucleotides between position +11 and +30, Dictyostelium discoideum"
xref: Reactome:REACT_99300 "Addition of Nucleotides 5 through 9 on the growing Transcript, Bos taurus"
xref: Reactome:REACT_99424 "Elongation of pre-rRNA transcript, Danio rerio"
is_a: GO:0034062 ! RNA polymerase activity
relationship: part_of GO:0032774 ! RNA biosynthetic process

[Term]
id: GO:0003900
name: obsolete DNA-directed RNA polymerase I activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)." [EC:2.7.7.6]
comment: This term was made obsolete because it represents the specific complex represented by the cellular component term 'DNA-directed RNA polymerase I complex ; GO:0005736'.
synonym: "DNA-directed RNA polymerase I activity" EXACT []
is_obsolete: true
replaced_by: GO:0003899

[Term]
id: GO:0003901
name: obsolete DNA-directed RNA polymerase II activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)." [EC:2.7.7.6]
comment: This term was made obsolete because it represents the specific complex represented by the cellular component term 'DNA-directed RNA polymerase II, core complex ; GO:0005665'.
synonym: "DNA-directed RNA polymerase II activity" EXACT []
is_obsolete: true
replaced_by: GO:0003899

[Term]
id: GO:0003902
name: obsolete DNA-directed RNA polymerase III activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)." [EC:2.7.7.6]
comment: This term was made obsolete because it represents the specific complex represented by the cellular component term 'DNA-directed RNA polymerase III complex ; GO:0005666'.
synonym: "DNA-directed RNA polymerase III activity" EXACT []
is_obsolete: true
replaced_by: GO:0003899

[Term]
id: GO:0003904
name: deoxyribodipyrimidine photo-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA). This reaction represents the reactivation of irradiated DNA by light." [EC:4.1.99.3]
subset: gosubset_prok
synonym: "CPD photolyase activity" EXACT [PMID:16302973]
synonym: "deoxyribocyclobutadipyrimidine pyrimidine-lyase activity" EXACT [EC:4.1.99.3]
synonym: "deoxyribodipyrimidine photolyase activity" EXACT []
synonym: "deoxyribonucleate pyrimidine dimer lyase (photosensitive)" EXACT [EC:4.1.99.3]
synonym: "deoxyribonucleic cyclobutane dipyrimidine photolyase activity" EXACT [EC:4.1.99.3]
synonym: "deoxyribonucleic photolyase activity" EXACT [EC:4.1.99.3]
synonym: "dipyrimidine photolyase (photosensitive)" EXACT [EC:4.1.99.3]
synonym: "DNA cyclobutane dipyrimidine photolyase activity" EXACT [EC:4.1.99.3]
synonym: "DNA-photoreactivating enzyme" RELATED [EC:4.1.99.3]
synonym: "photolyase activity" EXACT [EC:4.1.99.3]
synonym: "photoreactivating enzyme activity" RELATED [EC:4.1.99.3]
synonym: "phr A photolyase activity" EXACT [EC:4.1.99.3]
synonym: "PhrB photolyase activity" EXACT [EC:4.1.99.3]
synonym: "PRE" RELATED [EC:4.1.99.3]
xref: EC:4.1.99.3
xref: MetaCyc:DEOXYRIBODIPYRIMIDINE-PHOTOLYASE-RXN
is_a: GO:0003913 ! DNA photolyase activity

[Term]
id: GO:0003905
name: alkylbase DNA N-glycosylase activity
namespace: molecular_function
alt_id: GO:0004036
def: "Catalysis of the reaction: DNA with alkylated base + H2O = DNA with abasic site + alkylated base. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar to remove an alkylated base, leaving an apyrimidinic or apurinic site." [EC:3.2.2.21, GOC:elh, PMID:10872450, PMID:9224623]
subset: gosubset_prok
synonym: "3-methyladenine DNA glycosylase II" RELATED [EC:3.2.2.21]
synonym: "AlkA" RELATED [EC:3.2.2.21]
synonym: "alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)" BROAD [EC:3.2.2.21]
synonym: "alkylbase DNA glycosidase activity" EXACT []
synonym: "deoxyribonucleate 3-methyladenine glycosidase II" RELATED [EC:3.2.2.21]
synonym: "DNA glycosidase II activity" EXACT [EC:3.2.2.21]
synonym: "DNA-3-methyladenine glycosidase II activity" EXACT []
synonym: "DNA-3-methyladenine glycosylase II" RELATED [EC:3.2.2.21]
xref: EC:3.2.2.21
xref: MetaCyc:3.2.2.21-RXN
is_a: GO:0019104 ! DNA N-glycosylase activity

[Term]
id: GO:0003906
name: DNA-(apurinic or apyrimidinic site) lyase activity
namespace: molecular_function
def: "Catalysis of the cleavage of the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate." [EC:4.2.99.18]
subset: gosubset_prok
synonym: "AP endonuclease class I activity" NARROW [EC:4.2.99.18]
synonym: "AP lyase activity" EXACT [EC:4.2.99.18]
synonym: "AP site-DNA 5'-phosphomonoester-lyase activity" EXACT [EC:4.2.99.18]
synonym: "deoxyribonuclease (apurinic or apyrimidinic) activity" EXACT [EC:4.2.99.18]
synonym: "DNA-(apurinic or apyrimidinic site) 5'-phosphomonoester-lyase activity" EXACT [EC:4.2.99.18]
synonym: "E. coli endonuclease III" RELATED [EC:4.2.99.18]
synonym: "E. coli endonuclease III activity" NARROW [EC:4.2.99.18]
synonym: "endodeoxyribonuclease (apurinic or apyrimidinic) activity" EXACT [EC:4.2.99.18]
synonym: "endonuclease VIII activity" RELATED []
synonym: "micrococcus luteus UV endonuclease" NARROW [EC:4.2.99.18]
synonym: "Micrococcus luteus UV endonuclease activity" NARROW [EC:4.2.99.18]
synonym: "Phage-T(4) UV endonuclease activity" NARROW [EC:4.2.99.18]
synonym: "phage-T4 UV endonuclease" BROAD [EC:4.2.99.18]
synonym: "Phage-T4 UV endonuclease activity" NARROW [EC:4.2.99.18]
synonym: "X-ray endonuclease III" RELATED [EC:4.2.99.18]
xref: EC:4.2.99.18
xref: MetaCyc:4.2.99.18-RXN
xref: Reactome:REACT_103252 "Excision of the abasic sugar phosphate (dRP) residue at the strand break, Xenopus tropicalis"
xref: Reactome:REACT_1215 "Excision of the abasic sugar phosphate (dRP) residue at the strand break, Homo sapiens"
xref: Reactome:REACT_32396 "Excision of the abasic sugar phosphate (dRP) residue at the strand break, Rattus norvegicus"
xref: Reactome:REACT_55273 "Excision of the abasic sugar phosphate (dRP) residue at the strand break, Dictyostelium discoideum"
xref: Reactome:REACT_79844 "Excision of the abasic sugar phosphate (dRP) residue at the strand break, Mus musculus"
xref: Reactome:REACT_83849 "Excision of the abasic sugar phosphate (dRP) residue at the strand break, Danio rerio"
xref: Reactome:REACT_85754 "Excision of the abasic sugar phosphate (dRP) residue at the strand break, Sus scrofa"
xref: Reactome:REACT_96683 "Excision of the abasic sugar phosphate (dRP) residue at the strand break, Bos taurus"
xref: Reactome:REACT_97368 "Excision of the abasic sugar phosphate (dRP) residue at the strand break, Canis familiaris"
xref: Reactome:REACT_99910 "Excision of the abasic sugar phosphate (dRP) residue at the strand break, Taeniopygia guttata"
is_a: GO:0004520 ! endodeoxyribonuclease activity
is_a: GO:0016835 ! carbon-oxygen lyase activity

[Term]
id: GO:0003908
name: methylated-DNA-[protein]-cysteine S-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine." [EC:2.1.1.63]
subset: gosubset_prok
synonym: "6-O-methylguanine-DNA methyltransferase activity" EXACT [EC:2.1.1.63]
synonym: "DNA-6-O-methylguanine:[protein]-L-cysteine S-methyltransferase activity" EXACT []
synonym: "DNA-6-O-methylguanine:protein-L-cysteine S-methyltransferase activity" EXACT [EC:2.1.1.63]
synonym: "methylated-DNA-protein-cysteine S-methyltransferase activity" EXACT [EC:2.1.1.63]
synonym: "MGMT" EXACT []
synonym: "O-6-methylguanine-DNA-alkyltransferase activity" EXACT [EC:2.1.1.63]
synonym: "O6-alkylguanine-DNA alkyltransferase" BROAD []
xref: EC:2.1.1.63
xref: MetaCyc:2.1.1.63-RXN
xref: Reactome:REACT_102488 "MGMT/hAGT mediated DNA Damage Reversal, Canis familiaris"
xref: Reactome:REACT_103267 "MGMT/hAGT mediated DNA Damage Reversal, Gallus gallus"
xref: Reactome:REACT_103543 "MGMT/hAGT mediated DNA Damage Reversal, Dictyostelium discoideum"
xref: Reactome:REACT_104382 "MGMT/hAGT mediated DNA Damage Reversal, Taeniopygia guttata"
xref: Reactome:REACT_108289 "MGMT/hAGT mediated DNA Damage Reversal, Sus scrofa"
xref: Reactome:REACT_115725 "MGMT mediated DNA Damage Reversal, Gallus gallus"
xref: Reactome:REACT_1876 "MGMT/hAGT mediated DNA Damage Reversal, Homo sapiens"
xref: Reactome:REACT_28063 "MGMT/hAGT mediated DNA Damage Reversal, Mus musculus"
xref: Reactome:REACT_29167 "MGMT/hAGT mediated DNA Damage Reversal, Mycobacterium tuberculosis"
xref: Reactome:REACT_31652 "MGMT/hAGT mediated DNA Damage Reversal, Staphylococcus aureus N315"
xref: Reactome:REACT_82211 "MGMT/hAGT mediated DNA Damage Reversal, Danio rerio"
xref: Reactome:REACT_89238 "MGMT/hAGT mediated DNA Damage Reversal, Saccharomyces cerevisiae"
xref: Reactome:REACT_92208 "MGMT/hAGT mediated DNA Damage Reversal, Drosophila melanogaster"
xref: Reactome:REACT_94426 "MGMT/hAGT mediated DNA Damage Reversal, Rattus norvegicus"
xref: Reactome:REACT_96080 "MGMT/hAGT mediated DNA Damage Reversal, Xenopus tropicalis"
xref: Reactome:REACT_98636 "MGMT/hAGT mediated DNA Damage Reversal, Caenorhabditis elegans"
is_a: GO:0008172 ! S-methyltransferase activity

[Term]
id: GO:0003909
name: DNA ligase activity
namespace: molecular_function
def: "Catalysis of the formation of a phosphodiester bond between the 3'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another. This reaction requires an energy source such as ATP or NAD+." [ISBN:0716720094]
subset: gosubset_prok
xref: EC:6.5.1.-
xref: Reactome:REACT_100095 "DNA ligation via the single-nucleotide replacement pathway, Bos taurus"
xref: Reactome:REACT_100592 "Joining of adjacent Okazaki fragments, Canis familiaris"
xref: Reactome:REACT_101774 "Ligation of newly synthesized repair patch to incised DNA in GG-NER, Caenorhabditis elegans"
xref: Reactome:REACT_102755 "Ligation of DNA and formation of Holliday structures following repair synthesis, Gallus gallus"
xref: Reactome:REACT_102810 "Ligation of newly synthesized repair patch to incised DNA in GG-NER, Saccharomyces cerevisiae"
xref: Reactome:REACT_102989 "Ligation of DNA at sites of patch replacement, Rattus norvegicus"
xref: Reactome:REACT_103194 "Joining of adjacent Okazaki fragments, Mus musculus"
xref: Reactome:REACT_103238 "Ligation of newly synthesized repair patch to incised DNA in TC-NER, Canis familiaris"
xref: Reactome:REACT_103332 "Ligation of newly synthesized repair patch to incised DNA in GG-NER, Drosophila melanogaster"
xref: Reactome:REACT_103589 "Ligation of DNA and formation of Holliday structures following repair synthesis, Mycobacterium tuberculosis"
xref: Reactome:REACT_103607 "Ligation of newly synthesized repair patch to incised DNA in GG-NER, Mus musculus"
xref: Reactome:REACT_103914 "Ligation of DNA and formation of Holliday structures following repair synthesis, Plasmodium falciparum"
xref: Reactome:REACT_104033 "Ligation of newly synthesized repair patch to incised DNA in TC-NER, Sus scrofa"
xref: Reactome:REACT_105041 "Ligation of DNA and formation of Holliday structures following repair synthesis, Saccharomyces cerevisiae"
xref: Reactome:REACT_105804 "Ligation of DNA and formation of Holliday structures following repair synthesis, Dictyostelium discoideum"
xref: Reactome:REACT_106130 "Ligation of newly synthesized repair patch to incised DNA in TC-NER, Xenopus tropicalis"
xref: Reactome:REACT_106909 "Ligation of DNA and formation of Holliday structures following repair synthesis, Canis familiaris"
xref: Reactome:REACT_106919 "Joining of adjacent Okazaki fragments of the C-strand, Oryza sativa"
xref: Reactome:REACT_107577 "Ligation of DNA and formation of Holliday structures following repair synthesis, Drosophila melanogaster"
xref: Reactome:REACT_107734 "Ligation of newly synthesized repair patch to incised DNA in TC-NER, Mus musculus"
xref: Reactome:REACT_107864 "DNA ligation via the single-nucleotide replacement pathway, Dictyostelium discoideum"
xref: Reactome:REACT_108464 "Ligation of newly synthesized repair patch to incised DNA in TC-NER, Rattus norvegicus"
xref: Reactome:REACT_108675 "Ligation of DNA at sites of patch replacement, Mus musculus"
xref: Reactome:REACT_109229 "Ligation of newly synthesized repair patch to incised DNA in GG-NER, Plasmodium falciparum"
xref: Reactome:REACT_109434 "Joining of adjacent Okazaki fragments, Mycobacterium tuberculosis"
xref: Reactome:REACT_109730 "Ligation of newly synthesized repair patch to incised DNA in TC-NER, Schizosaccharomyces pombe"
xref: Reactome:REACT_109841 "Ligation of newly synthesized repair patch to incised DNA in TC-NER, Saccharomyces cerevisiae"
xref: Reactome:REACT_110352 "Ligation of newly synthesized repair patch to incised DNA in TC-NER, Caenorhabditis elegans"
xref: Reactome:REACT_112118 "Removal of repair proteins and ligation of the processed ends of the DNA double-strand break, Mus musculus"
xref: Reactome:REACT_112246 "Removal of repair proteins and ligation of the processed ends of the DNA double-strand break, Sus scrofa"
xref: Reactome:REACT_113076 "Removal of repair proteins and ligation of the processed ends of the DNA double-strand break, Xenopus tropicalis"
xref: Reactome:REACT_113217 "Removal of repair proteins and ligation of the processed ends of the DNA double-strand break, Gallus gallus"
xref: Reactome:REACT_113661 "Removal of repair proteins and ligation of the processed ends of the DNA double-strand break, Canis familiaris"
xref: Reactome:REACT_113851 "Removal of repair proteins and ligation of the processed ends of the DNA double-strand break, Bos taurus"
xref: Reactome:REACT_114038 "Removal of repair proteins and ligation of the processed ends of the DNA double-strand break, Rattus norvegicus"
xref: Reactome:REACT_114285 "Removal of repair proteins and ligation of the processed ends of the DNA double-strand break, Danio rerio"
xref: Reactome:REACT_114706 "Removal of repair proteins and ligation of the processed ends of the DNA double-strand break, Taeniopygia guttata"
xref: Reactome:REACT_115886 "Removal of repair proteins and ligation of the processed ends of the DNA double-strand break, Gallus gallus"
xref: Reactome:REACT_12 "Removal of repair proteins and ligation of the processed ends of the DNA double-strand break, Homo sapiens"
xref: Reactome:REACT_1247 "Ligation of DNA at sites of patch replacement, Homo sapiens"
xref: Reactome:REACT_1659 "DNA ligation via the single-nucleotide replacement pathway, Homo sapiens"
xref: Reactome:REACT_1889 "Joining of adjacent Okazaki fragments, Homo sapiens"
xref: Reactome:REACT_2181 "Ligation of newly synthesized repair patch to incised DNA in GG-NER, Homo sapiens"
xref: Reactome:REACT_29134 "Ligation of DNA and formation of Holliday structures following repair synthesis, Rattus norvegicus"
xref: Reactome:REACT_29359 "Ligation of newly synthesized repair patch to incised DNA in TC-NER, Oryza sativa"
xref: Reactome:REACT_29498 "Joining of adjacent Okazaki fragments of the C-strand, Mus musculus"
xref: Reactome:REACT_29665 "Ligation of newly synthesized repair patch to incised DNA in TC-NER, Bos taurus"
xref: Reactome:REACT_29882 "Ligation of DNA at sites of patch replacement, Xenopus tropicalis"
xref: Reactome:REACT_30614 "Joining of adjacent Okazaki fragments, Caenorhabditis elegans"
xref: Reactome:REACT_31624 "Ligation of newly synthesized repair patch to incised DNA in TC-NER, Arabidopsis thaliana"
xref: Reactome:REACT_31707 "Ligation of newly synthesized repair patch to incised DNA in TC-NER, Dictyostelium discoideum"
xref: Reactome:REACT_31800 "Ligation of DNA at sites of patch replacement, Sus scrofa"
xref: Reactome:REACT_32203 "Joining of adjacent Okazaki fragments, Gallus gallus"
xref: Reactome:REACT_32488 "Ligation of newly synthesized repair patch to incised DNA in GG-NER, Rattus norvegicus"
xref: Reactome:REACT_33776 "Ligation of newly synthesized repair patch to incised DNA in TC-NER, Gallus gallus"
xref: Reactome:REACT_34177 "Ligation of newly synthesized repair patch to incised DNA in GG-NER, Bos taurus"
xref: Reactome:REACT_34490 "Ligation of newly synthesized repair patch to incised DNA in GG-NER, Danio rerio"
xref: Reactome:REACT_527 "Ligation of newly synthesized repair patch to incised DNA in TC-NER, Homo sapiens"
xref: Reactome:REACT_77023 "Ligation of DNA and formation of Holliday structures following repair synthesis, Mus musculus"
xref: Reactome:REACT_77057 "Joining of adjacent Okazaki fragments, Dictyostelium discoideum"
xref: Reactome:REACT_78542 "Joining of adjacent Okazaki fragments, Sus scrofa"
xref: Reactome:REACT_78969 "Joining of adjacent Okazaki fragments of the C-strand, Bos taurus"
xref: Reactome:REACT_79227 "Ligation of newly synthesized repair patch to incised DNA in GG-NER, Sus scrofa"
xref: Reactome:REACT_79753 "Joining of adjacent Okazaki fragments, Xenopus tropicalis"
xref: Reactome:REACT_7994 "Joining of adjacent Okazaki fragments of the C-strand, Homo sapiens"
xref: Reactome:REACT_80840 "Ligation of newly synthesized repair patch to incised DNA in GG-NER, Xenopus tropicalis"
xref: Reactome:REACT_81358 "Ligation of newly synthesized repair patch to incised DNA in GG-NER, Dictyostelium discoideum"
xref: Reactome:REACT_81832 "Ligation of DNA and formation of Holliday structures following repair synthesis, Sus scrofa"
xref: Reactome:REACT_819 "Ligation of DNA and formation of Holliday structures following repair synthesis, Homo sapiens"
xref: Reactome:REACT_81990 "Joining of adjacent Okazaki fragments of the C-strand, Danio rerio"
xref: Reactome:REACT_82032 "Joining of adjacent Okazaki fragments, Schizosaccharomyces pombe"
xref: Reactome:REACT_82667 "Ligation of newly synthesized repair patch to incised DNA in GG-NER, Schizosaccharomyces pombe"
xref: Reactome:REACT_82701 "DNA ligation via the single-nucleotide replacement pathway, Xenopus tropicalis"
xref: Reactome:REACT_82930 "Ligation of DNA and formation of Holliday structures following repair synthesis, Caenorhabditis elegans"
xref: Reactome:REACT_83571 "Ligation of DNA at sites of patch replacement, Danio rerio"
xref: Reactome:REACT_84527 "Joining of adjacent Okazaki fragments of the C-strand, Xenopus tropicalis"
xref: Reactome:REACT_84993 "Ligation of newly synthesized repair patch to incised DNA in GG-NER, Arabidopsis thaliana"
xref: Reactome:REACT_85398 "Ligation of newly synthesized repair patch to incised DNA in TC-NER, Drosophila melanogaster"
xref: Reactome:REACT_85781 "Joining of adjacent Okazaki fragments of the C-strand, Schizosaccharomyces pombe"
xref: Reactome:REACT_85839 "Joining of adjacent Okazaki fragments, Plasmodium falciparum"
xref: Reactome:REACT_85910 "Joining of adjacent Okazaki fragments of the C-strand, Canis familiaris"
xref: Reactome:REACT_85997 "Ligation of newly synthesized repair patch to incised DNA in GG-NER, Canis familiaris"
xref: Reactome:REACT_86056 "Ligation of newly synthesized repair patch to incised DNA in GG-NER, Gallus gallus"
xref: Reactome:REACT_86721 "Joining of adjacent Okazaki fragments, Saccharomyces cerevisiae"
xref: Reactome:REACT_87237 "Ligation of DNA at sites of patch replacement, Arabidopsis thaliana"
xref: Reactome:REACT_88790 "Ligation of newly synthesized repair patch to incised DNA in GG-NER, Oryza sativa"
xref: Reactome:REACT_88893 "Joining of adjacent Okazaki fragments, Rattus norvegicus"
xref: Reactome:REACT_89311 "DNA ligation via the single-nucleotide replacement pathway, Mus musculus"
xref: Reactome:REACT_89618 "Joining of adjacent Okazaki fragments of the C-strand, Rattus norvegicus"
xref: Reactome:REACT_89621 "Ligation of DNA and formation of Holliday structures following repair synthesis, Bos taurus"
xref: Reactome:REACT_89952 "Ligation of newly synthesized repair patch to incised DNA in TC-NER, Plasmodium falciparum"
xref: Reactome:REACT_90164 "Joining of adjacent Okazaki fragments, Drosophila melanogaster"
xref: Reactome:REACT_90240 "Ligation of DNA and formation of Holliday structures following repair synthesis, Oryza sativa"
xref: Reactome:REACT_90705 "Joining of adjacent Okazaki fragments, Danio rerio"
xref: Reactome:REACT_9073 "2-LTR formation due to circularization of viral DNA, Homo sapiens"
xref: Reactome:REACT_90997 "Joining of adjacent Okazaki fragments, Oryza sativa"
xref: Reactome:REACT_91447 "Ligation of DNA at sites of patch replacement, Canis familiaris"
xref: Reactome:REACT_91602 "DNA ligation via the single-nucleotide replacement pathway, Canis familiaris"
xref: Reactome:REACT_92092 "Joining of adjacent Okazaki fragments of the C-strand, Sus scrofa"
xref: Reactome:REACT_92345 "Joining of adjacent Okazaki fragments, Arabidopsis thaliana"
xref: Reactome:REACT_92550 "Ligation of DNA and formation of Holliday structures following repair synthesis, Arabidopsis thaliana"
xref: Reactome:REACT_92807 "Ligation of DNA at sites of patch replacement, Bos taurus"
xref: Reactome:REACT_93826 "DNA ligation via the single-nucleotide replacement pathway, Danio rerio"
xref: Reactome:REACT_94103 "DNA ligation via the single-nucleotide replacement pathway, Rattus norvegicus"
xref: Reactome:REACT_94317 "Joining of adjacent Okazaki fragments of the C-strand, Arabidopsis thaliana"
xref: Reactome:REACT_95309 "Ligation of newly synthesized repair patch to incised DNA in TC-NER, Mycobacterium tuberculosis"
xref: Reactome:REACT_95407 "Ligation of newly synthesized repair patch to incised DNA in GG-NER, Mycobacterium tuberculosis"
xref: Reactome:REACT_96323 "Ligation of DNA and formation of Holliday structures following repair synthesis, Schizosaccharomyces pombe"
xref: Reactome:REACT_97779 "Ligation of DNA and formation of Holliday structures following repair synthesis, Xenopus tropicalis"
xref: Reactome:REACT_97800 "Ligation of DNA and formation of Holliday structures following repair synthesis, Danio rerio"
xref: Reactome:REACT_98012 "Joining of adjacent Okazaki fragments, Bos taurus"
xref: Reactome:REACT_98339 "Ligation of DNA at sites of patch replacement, Oryza sativa"
xref: Reactome:REACT_99685 "Ligation of newly synthesized repair patch to incised DNA in TC-NER, Danio rerio"
is_a: GO:0016886 ! ligase activity, forming phosphoric ester bonds
relationship: part_of GO:0006266 ! DNA ligation

[Term]
id: GO:0003910
name: DNA ligase (ATP) activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m)." [EC:6.5.1.1]
subset: gosubset_prok
synonym: "deoxyribonucleate ligase" BROAD [EC:6.5.1.1]
synonym: "deoxyribonucleic acid joinase" BROAD [EC:6.5.1.1]
synonym: "deoxyribonucleic acid ligase" BROAD [EC:6.5.1.1]
synonym: "deoxyribonucleic acid repair enzyme" RELATED [EC:6.5.1.1]
synonym: "deoxyribonucleic acid-joining enzyme" RELATED [EC:6.5.1.1]
synonym: "deoxyribonucleic joinase" BROAD [EC:6.5.1.1]
synonym: "deoxyribonucleic ligase" BROAD [EC:6.5.1.1]
synonym: "deoxyribonucleic repair enzyme" RELATED [EC:6.5.1.1]
synonym: "deoxyribonucleic-joining enzyme" RELATED [EC:6.5.1.1]
synonym: "DNA joinase activity" BROAD [EC:6.5.1.1]
synonym: "DNA repair enzyme activity" RELATED [EC:6.5.1.1]
synonym: "DNA-joining enzyme" RELATED [EC:6.5.1.1]
synonym: "poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming)" EXACT [EC:6.5.1.1]
synonym: "polydeoxyribonucleotide synthase (ATP) activity" EXACT [EC:6.5.1.1]
synonym: "polynucleotide ligase" BROAD [EC:6.5.1.1]
synonym: "polynucleotide ligase (ATP) activity" EXACT [EC:6.5.1.1]
synonym: "sealase activity" RELATED [EC:6.5.1.1]
xref: EC:6.5.1.1
xref: MetaCyc:DNA-LIGASE-ATP-RXN
is_a: GO:0003909 ! DNA ligase activity

[Term]
id: GO:0003911
name: DNA ligase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m)." [EC:6.5.1.2]
subset: gosubset_prok
synonym: "deoxyribonucleate ligase" BROAD [EC:6.5.1.2]
synonym: "deoxyribonucleic acid joinase" BROAD [EC:6.5.1.2]
synonym: "deoxyribonucleic acid ligase" BROAD [EC:6.5.1.2]
synonym: "deoxyribonucleic joinase" BROAD [EC:6.5.1.2]
synonym: "deoxyribonucleic ligase" BROAD [EC:6.5.1.2]
synonym: "deoxyribonucleic repair enzyme" RELATED [EC:6.5.1.2]
synonym: "deoxyribonucleic-joining enzyme" RELATED [EC:6.5.1.2]
synonym: "DNA joinase activity" BROAD [EC:6.5.1.2]
synonym: "DNA ligase (NAD)" EXACT [EC:6.5.1.2]
synonym: "DNA repair enzyme activity" RELATED [EC:6.5.1.2]
synonym: "DNA-joining enzyme" RELATED [EC:6.5.1.2]
synonym: "poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming, NMN-forming)" EXACT [EC:6.5.1.2]
synonym: "Polydeoxyribonucleotide synthase (NAD(+)) activity" EXACT [EC:6.5.1.2]
synonym: "polydeoxyribonucleotide synthase (NAD)" EXACT [EC:6.5.1.2]
synonym: "polydeoxyribonucleotide synthase (NAD+) activity" EXACT [EC:6.5.1.2]
synonym: "polynucleotide ligase" BROAD [EC:6.5.1.2]
synonym: "polynucleotide ligase (NAD(+)) activity" EXACT [EC:6.5.1.2]
synonym: "polynucleotide ligase (NAD)" EXACT [EC:6.5.1.2]
synonym: "polynucleotide ligase (NAD+) activity" EXACT [EC:6.5.1.2]
synonym: "polynucleotide ligase (nicotinamide adenine dinucleotide)" EXACT [EC:6.5.1.2]
synonym: "polynucleotide synthetase (nicotinamide adenine dinucleotide)" EXACT [EC:6.5.1.2]
synonym: "polynucleotide synthetase activity" EXACT [EC:6.5.1.2]
xref: EC:6.5.1.2
xref: MetaCyc:DNA-LIGASE-NAD+-RXN
is_a: GO:0003909 ! DNA ligase activity

[Term]
id: GO:0003912
name: DNA nucleotidylexotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)." [EC:2.7.7.31]
synonym: "addase activity" EXACT [EC:2.7.7.31]
synonym: "deoxynucleotidyl terminal transferase activity" EXACT [EC:2.7.7.31]
synonym: "deoxyribonucleic acid nucleotidyltransferase activity" EXACT [EC:2.7.7.31]
synonym: "deoxyribonucleic nucleotidyltransferase activity" EXACT [EC:2.7.7.31]
synonym: "nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" EXACT [EC:2.7.7.31]
synonym: "TdT" RELATED [EC:2.7.7.31]
synonym: "terminal addition enzyme activity" RELATED [EC:2.7.7.31]
synonym: "terminal deoxynucleotide transferase activity" EXACT [EC:2.7.7.31]
synonym: "terminal deoxynucleotidyltransferase activity" EXACT [EC:2.7.7.31]
synonym: "terminal deoxyribonucleotidyltransferase activity" EXACT [EC:2.7.7.31]
synonym: "terminal transferase activity" EXACT [EC:2.7.7.31]
xref: EC:2.7.7.31
xref: MetaCyc:DNA-NUCLEOTIDYLEXOTRANSFERASE-RXN
is_a: GO:0016779 ! nucleotidyltransferase activity

[Term]
id: GO:0003913
name: DNA photolyase activity
namespace: molecular_function
def: "Catalysis of the repair of a photoproduct resulting from ultraviolet irradiation of two adjacent pyrimidine residues in DNA." [GOC:mah, PMID:11124949]
subset: gosubset_prok
xref: EC:4.1.99.-
xref: MetaCyc:DEOXYRIBODIPYRIMIDINE-PHOTOLYASE-RXN
is_a: GO:0016830 ! carbon-carbon lyase activity

[Term]
id: GO:0003914
name: DNA (6-4) photolyase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyrimidine-pyrimidone (6-4) photoproduct (in DNA) = 2 pyrimidine residues (in DNA). Catalyzes the reactivation of ultraviolet-irradiated DNA." [GOC:mah, PMID:11124949]
xref: EC:4.1.99.13
xref: MetaCyc:RXN-10771
is_a: GO:0003913 ! DNA photolyase activity

[Term]
id: GO:0003916
name: DNA topoisomerase activity
namespace: molecular_function
alt_id: GO:0009387
def: "Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA." [GOC:mah, PMID:8811192]
subset: gosubset_prok
xref: EC:5.99.1.-
xref: MetaCyc:5.99.1.2-RXN
is_a: GO:0016853 ! isomerase activity
relationship: has_part GO:0003677 ! DNA binding

[Term]
id: GO:0003917
name: DNA topoisomerase type I activity
namespace: molecular_function
def: "Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle." [PMID:8811192]
comment: Note that a further distinction, between type IA and type IB topoisomerases, is based on sequence or structural similarity between gene products that possess type I catalytic activity.
subset: gosubset_prok
synonym: "deoxyribonucleate topoisomerase" BROAD [EC:5.99.1.2]
synonym: "DNA topoisomerase I activity" NARROW []
synonym: "nicking-closing enzyme activity" RELATED [EC:5.99.1.2]
synonym: "omega-protein activity" RELATED [EC:5.99.1.2]
synonym: "relaxing enzyme activity" RELATED [EC:5.99.1.2]
synonym: "swivelase activity" RELATED [EC:5.99.1.2]
synonym: "topoisomerase" BROAD [EC:5.99.1.2]
synonym: "type I DNA topoisomerase activity" EXACT []
synonym: "type I topoisomerase activity" EXACT []
synonym: "untwisting enzyme activity" RELATED [EC:5.99.1.2]
xref: EC:5.99.1.2
xref: MetaCyc:5.99.1.2-RXN
is_a: GO:0003916 ! DNA topoisomerase activity

[Term]
id: GO:0003918
name: DNA topoisomerase type II (ATP-hydrolyzing) activity
namespace: molecular_function
def: "Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2." [PMID:8811192]
subset: gosubset_prok
synonym: "deoxyribonucleate topoisomerase" BROAD [EC:5.99.1.3]
synonym: "deoxyribonucleic topoisomerase activity" EXACT [EC:5.99.1.3]
synonym: "DNA topoisomerase (ATP-hydrolysing)" BROAD [EC:5.99.1.3]
synonym: "DNA topoisomerase II" RELATED [EC:5.99.1.3]
synonym: "DNA topoisomerase IV activity" EXACT []
synonym: "DNA topoisomerase type II activity" RELATED []
synonym: "topoisomerase" BROAD [EC:5.99.1.3]
synonym: "topoisomerase II" RELATED []
synonym: "type II DNA topoisomerase activity" EXACT [EC:5.99.1.3]
xref: EC:5.99.1.3
xref: MetaCyc:5.99.1.3-RXN
xref: Wikipedia:Type_II_topoisomerase
is_a: GO:0008094 ! DNA-dependent ATPase activity
is_a: GO:0061505 ! DNA topoisomerase II activity

[Term]
id: GO:0003919
name: FMN adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + FMN = diphosphate + FAD." [EC:2.7.7.2, RHEA:17240]
subset: gosubset_prok
synonym: "adenosine triphosphate-riboflavin mononucleotide transadenylase activity" EXACT [EC:2.7.7.2]
synonym: "adenosine triphosphate-riboflavine mononucleotide transadenylase activity" EXACT [EC:2.7.7.2]
synonym: "ATP:FMN adenylyltransferase activity" EXACT []
synonym: "FAD diphosphorylase activity" EXACT [EC:2.7.7.2]
synonym: "FAD pyrophosphorylase activity" EXACT [EC:2.7.7.2]
synonym: "FAD synthetase activity" EXACT [EC:2.7.7.2]
synonym: "flavin adenine dinucleotide synthetase activity" EXACT [EC:2.7.7.2]
synonym: "riboflavin adenine dinucleotide pyrophosphorylase activity" EXACT [EC:2.7.7.2]
synonym: "riboflavin mononucleotide adenylyltransferase activity" EXACT [EC:2.7.7.2]
synonym: "riboflavine adenine dinucleotide adenylyltransferase activity" EXACT [EC:2.7.7.2]
xref: EC:2.7.7.2
xref: KEGG:R00161
xref: MetaCyc:FADSYN-RXN
xref: Reactome:REACT_100498 "FMN is futher phosphorylated to FAD, Taeniopygia guttata"
xref: Reactome:REACT_101323 "FMN is futher phosphorylated to FAD, Arabidopsis thaliana"
xref: Reactome:REACT_101363 "FMN is futher phosphorylated to FAD, Oryza sativa"
xref: Reactome:REACT_103632 "FMN is futher phosphorylated to FAD, Sus scrofa"
xref: Reactome:REACT_11128 "FMN is futher phosphorylated to FAD, Homo sapiens"
xref: Reactome:REACT_32090 "FMN is futher phosphorylated to FAD, Dictyostelium discoideum"
xref: Reactome:REACT_32724 "FMN is futher phosphorylated to FAD, Danio rerio"
xref: Reactome:REACT_34649 "FMN is futher phosphorylated to FAD, Plasmodium falciparum"
xref: Reactome:REACT_80112 "FMN is futher phosphorylated to FAD, Mus musculus"
xref: Reactome:REACT_81244 "FMN is futher phosphorylated to FAD, Rattus norvegicus"
xref: Reactome:REACT_85313 "FMN is futher phosphorylated to FAD, Canis familiaris"
xref: Reactome:REACT_85342 "FMN is futher phosphorylated to FAD, Schizosaccharomyces pombe"
xref: Reactome:REACT_85926 "FMN is futher phosphorylated to FAD, Saccharomyces cerevisiae"
xref: Reactome:REACT_91206 "FMN is futher phosphorylated to FAD, Caenorhabditis elegans"
xref: Reactome:REACT_92304 "FMN is futher phosphorylated to FAD, Bos taurus"
xref: Reactome:REACT_92992 "FMN is futher phosphorylated to FAD, Xenopus tropicalis"
xref: RHEA:17240
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0003920
name: GMP reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: IMP + NADP(+) + NH(4)(+) = GMP + 2 H(+) + NADPH." [EC:1.7.1.7, RHEA:17188]
comment: Note that this function was formerly EC:1.6.6.8.
subset: gosubset_prok
synonym: "guanosine 5'-monophosphate oxidoreductase activity" EXACT [EC:1.7.1.7]
synonym: "guanosine 5'-monophosphate reductase activity" EXACT [EC:1.7.1.7]
synonym: "guanosine 5'-phosphate reductase activity" EXACT [EC:1.7.1.7]
synonym: "guanosine monophosphate reductase activity" EXACT [EC:1.7.1.7]
synonym: "guanylate reductase activity" RELATED [EC:1.7.1.7]
synonym: "inosine-5'-phosphate:NADP+ oxidoreductase (aminating)" EXACT [EC:1.7.1.7]
synonym: "NADPH2:guanosine-5'-phosphate oxidoreductase (deaminating)" EXACT [EC:1.7.1.7]
synonym: "NADPH:GMP oxidoreductase (deaminating) activity" EXACT [EC:1.7.1.7]
synonym: "NADPH:guanosine-5'-phosphate oxidoreductase (deaminating) activity" EXACT [EC:1.7.1.7]
xref: EC:1.7.1.7
xref: KEGG:R01134
xref: MetaCyc:GMP-REDUCT-RXN
xref: Reactome:REACT_21383 "GMP + NADPH + H+ => IMP + NADP+ + NH4+ [GMPR,GMPR2], Homo sapiens"
xref: RHEA:17188
is_a: GO:0016657 ! oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor

[Term]
id: GO:0003921
name: GMP synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + xanthosine 5'-phosphate + NH3 = AMP + diphosphate + GMP." [EC:6.3.4.1]
synonym: "guanylate synthetase activity" EXACT [EC:6.3.4.1]
synonym: "xanthosine 5'-monophosphate aminase activity" EXACT [EC:6.3.4.1]
synonym: "Xanthosine-5'-phosphate--ammonia ligase activity" EXACT [EC:6.3.4.1]
synonym: "xanthosine-5'-phosphate-ammonia ligase activity" EXACT [EC:6.3.4.1]
synonym: "xanthosine-5'-phosphate:ammonia ligase (AMP-forming)" EXACT [EC:6.3.4.1]
synonym: "XMP aminase activity" EXACT [EC:6.3.4.1]
xref: EC:6.3.4.1
xref: MetaCyc:GMP-SYN-NH3-RXN
xref: Reactome:REACT_101174 "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate, Bos taurus"
xref: Reactome:REACT_105280 "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate, Rattus norvegicus"
xref: Reactome:REACT_106308 "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate, Taeniopygia guttata"
xref: Reactome:REACT_107658 "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate, Plasmodium falciparum"
xref: Reactome:REACT_108131 "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_109470 "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate, Mycobacterium tuberculosis"
xref: Reactome:REACT_110787 "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate, Oryza sativa"
xref: Reactome:REACT_114078 "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate, Xenopus tropicalis"
xref: Reactome:REACT_28584 "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate, Sus scrofa"
xref: Reactome:REACT_29905 "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate, Gallus gallus"
xref: Reactome:REACT_32520 "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate, Staphylococcus aureus N315"
xref: Reactome:REACT_32733 "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_37631 "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate, Canis familiaris"
xref: Reactome:REACT_62336 "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate, Mus musculus"
xref: Reactome:REACT_628 "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate, Homo sapiens"
xref: Reactome:REACT_78067 "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate, Arabidopsis thaliana"
xref: Reactome:REACT_82243 "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_90423 "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate, Drosophila melanogaster"
xref: Reactome:REACT_91249 "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate, Danio rerio"
xref: Reactome:REACT_96003 "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate, Escherichia coli"
xref: Reactome:REACT_96357 "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate, Caenorhabditis elegans"
xref: RHEA:18304
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds
relationship: part_of GO:0006177 ! GMP biosynthetic process

[Term]
id: GO:0003922
name: GMP synthase (glutamine-hydrolyzing) activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate." [EC:6.3.5.2]
subset: gosubset_prok
synonym: "glutamine amidotransferase activity" EXACT [EC:6.3.5.2]
synonym: "GMP synthase (glutamine-hydrolysing)" EXACT [EC:6.3.5.2]
synonym: "GMP synthetase (glutamine-hydrolysing)" EXACT [EC:6.3.5.2]
synonym: "GMP synthetase (glutamine-hydrolyzing) activity" EXACT [EC:6.3.5.2]
synonym: "guanosine 5'-monophosphate synthetase activity" EXACT [EC:6.3.5.2]
synonym: "guanosine monophosphate synthetase (glutamine-hydrolyzing)" EXACT [EC:6.3.5.2]
synonym: "guanylate synthetase (glutamine-hydrolyzing)" EXACT [EC:6.3.5.2]
synonym: "xanthosine 5'-phosphate amidotransferase activity" EXACT [EC:6.3.5.2]
synonym: "xanthosine-5'-phosphate:L-glutamine amido-ligase (AMP-forming)" EXACT [EC:6.3.5.2]
xref: EC:6.3.5.2
xref: MetaCyc:GMP-SYN-GLUT-RXN
xref: Reactome:REACT_116095 "xanthosine 5'-monophosphate (XMP) + L-glutamine + ATP + H2O => guanosine 5'-monophosphate (GMP) + L-glutamate + adenosine 5'-monophosphate (AMP) + pyrophosphate, Gallus gallus"
xref: RHEA:11683
xref: Wikipedia:GMP_synthase_(glutamine-hydrolysing)
is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor

[Term]
id: GO:0003923
name: GPI-anchor transamidase activity
namespace: molecular_function
def: "Catalysis of the formation of the linkage between a protein and a glycosylphosphatidylinositol anchor. The reaction probably occurs by subjecting a peptide bond to nucleophilic attack by the amino group of ethanolamine-GPI, transferring the protein from a signal peptide to the GPI anchor." [ISBN:0471331309]
xref: EC:3.-.-.-
xref: Reactome:REACT_100692 "uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide, Rattus norvegicus"
xref: Reactome:REACT_101782 "uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide, Danio rerio"
xref: Reactome:REACT_103715 "uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide, Canis familiaris"
xref: Reactome:REACT_113833 "uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide, Xenopus tropicalis"
xref: Reactome:REACT_1777 "uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide, Homo sapiens"
xref: Reactome:REACT_34799 "uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide, Sus scrofa"
xref: Reactome:REACT_90230 "uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide, Mus musculus"
xref: Reactome:REACT_92319 "uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide, Bos taurus"
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0003924
name: GTPase activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_yeast
subset: gosubset_prok
synonym: "ARF small monomeric GTPase activity" NARROW []
synonym: "dynamin GTPase activity" NARROW []
synonym: "heterotrimeric G-protein GTPase activity" NARROW []
synonym: "heterotrimeric G-protein GTPase, alpha-subunit" RELATED []
synonym: "heterotrimeric G-protein GTPase, beta-subunit" RELATED []
synonym: "heterotrimeric G-protein GTPase, gamma-subunit" RELATED []
synonym: "hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement" BROAD []
synonym: "protein-synthesizing GTPase activity" NARROW []
synonym: "protein-synthesizing GTPase activity, elongation" NARROW []
synonym: "protein-synthesizing GTPase activity, initiation" NARROW []
synonym: "protein-synthesizing GTPase activity, termination" NARROW []
synonym: "Rab small monomeric GTPase activity" NARROW []
synonym: "Ran small monomeric GTPase activity" NARROW []
synonym: "Ras small monomeric GTPase activity" NARROW []
synonym: "RHEB small monomeric GTPase activity" NARROW []
synonym: "Rho small monomeric GTPase activity" NARROW []
synonym: "Sar small monomeric GTPase activity" NARROW []
synonym: "signal-recognition-particle GTPase activity" NARROW []
synonym: "small monomeric GTPase activity" NARROW []
synonym: "tubulin GTPase activity" NARROW []
xref: Reactome:REACT_100432 "trans-Golgi Network Vesicle Scission, Mus musculus"
xref: Reactome:REACT_100708 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Bos taurus"
xref: Reactome:REACT_101121 "trans-Golgi Network Vesicle Scission, Rattus norvegicus"
xref: Reactome:REACT_101520 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Drosophila melanogaster"
xref: Reactome:REACT_101563 "Loss of Sar1b GTPase, Arabidopsis thaliana"
xref: Reactome:REACT_101678 "G-protein alpha subunit is inactivated, Gallus gallus"
xref: Reactome:REACT_102040 "Adenylate cyclase increases the GTPase activity of G alpha-olf, Xenopus tropicalis"
xref: Reactome:REACT_102208 "Adenylate cyclase increases the GTPase activity of G alpha-olf, Danio rerio"
xref: Reactome:REACT_102307 "Adenylate cyclase increases the GTPase activity of Gi alpha, Gallus gallus"
xref: Reactome:REACT_102371 "Vesicle Uncoating, Oryza sativa"
xref: Reactome:REACT_102510 "trans-Golgi Network Vesicle Scission, Bos taurus"
xref: Reactome:REACT_102532 "Loss of Sar1b GTPase, Danio rerio"
xref: Reactome:REACT_103518 "trans-Golgi Network Lysosomal Vesicle Scission, Sus scrofa"
xref: Reactome:REACT_104081 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP, Mus musculus"
xref: Reactome:REACT_104477 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Canis familiaris"
xref: Reactome:REACT_104739 "Loss of Sar1b GTPase, Dictyostelium discoideum"
xref: Reactome:REACT_105323 "trans-Golgi Network Vesicle Scission, Canis familiaris"
xref: Reactome:REACT_105697 "G-protein alpha subunit is inactivated, Saccharomyces cerevisiae"
xref: Reactome:REACT_105708 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Xenopus tropicalis"
xref: Reactome:REACT_105854 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Taeniopygia guttata"
xref: Reactome:REACT_106121 "Vesicle Uncoating, Saccharomyces cerevisiae"
xref: Reactome:REACT_106217 "Hydrolysis of eEF1A:GTP, Dictyostelium discoideum"
xref: Reactome:REACT_106301 "Adenylate cyclase increases the GTPase activity of G alpha-olf, Mus musculus"
xref: Reactome:REACT_106528 "trans-Golgi Network Lysosomal Vesicle Scission, Canis familiaris"
xref: Reactome:REACT_107176 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP, Taeniopygia guttata"
xref: Reactome:REACT_107306 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Rattus norvegicus"
xref: Reactome:REACT_107730 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP, Saccharomyces cerevisiae"
xref: Reactome:REACT_107820 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Canis familiaris"
xref: Reactome:REACT_108363 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Drosophila melanogaster"
xref: Reactome:REACT_108653 "G-protein alpha subunit is inactivated, Bos taurus"
xref: Reactome:REACT_108825 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Drosophila melanogaster"
xref: Reactome:REACT_108837 "trans-Golgi Network Vesicle Scission, Xenopus tropicalis"
xref: Reactome:REACT_109360 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Sus scrofa"
xref: Reactome:REACT_109897 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Danio rerio"
xref: Reactome:REACT_110131 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP, Gallus gallus"
xref: Reactome:REACT_110443 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Xenopus tropicalis"
xref: Reactome:REACT_110557 "trans-Golgi Network Vesicle Scission, Danio rerio"
xref: Reactome:REACT_110859 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Caenorhabditis elegans"
xref: Reactome:REACT_110879 "G-protein alpha subunit is inactivated, Canis familiaris"
xref: Reactome:REACT_110931 "G-protein alpha subunit is inactivated, Sus scrofa"
xref: Reactome:REACT_111994 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP, Xenopus tropicalis"
xref: Reactome:REACT_112104 "Endocytosis (internalization) of clathrin-coated vesicle, Sus scrofa"
xref: Reactome:REACT_112254 "Endocytosis (internalization) of clathrin-coated vesicle, Xenopus tropicalis"
xref: Reactome:REACT_112389 "Disassembly of COPII coated vesicle, Gallus gallus"
xref: Reactome:REACT_112587 "trans-Golgi Network Vesicle Scission, Schizosaccharomyces pombe"
xref: Reactome:REACT_112651 "Vesicle Uncoating, Xenopus tropicalis"
xref: Reactome:REACT_112671 "Vesicle Uncoating, Plasmodium falciparum"
xref: Reactome:REACT_113058 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Saccharomyces cerevisiae"
xref: Reactome:REACT_113209 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP, Schizosaccharomyces pombe"
xref: Reactome:REACT_113727 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Saccharomyces cerevisiae"
xref: Reactome:REACT_113832 "Formation of clathrin coated vesicle, Bos taurus"
xref: Reactome:REACT_113952 "Formation of clathrin coated vesicle, Schizosaccharomyces pombe"
xref: Reactome:REACT_113954 "Endocytosis (internalization) of clathrin-coated vesicle, Schizosaccharomyces pombe"
xref: Reactome:REACT_114148 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Schizosaccharomyces pombe"
xref: Reactome:REACT_114153 "Loss of Sar1b GTPase, Xenopus tropicalis"
xref: Reactome:REACT_114188 "Formation of clathrin coated vesicle, Sus scrofa"
xref: Reactome:REACT_114210 "G-protein alpha subunit is inactivated, Schizosaccharomyces pombe"
xref: Reactome:REACT_114331 "trans-Golgi Network Vesicle Scission, Taeniopygia guttata"
xref: Reactome:REACT_114379 "Formation of clathrin coated vesicle, Taeniopygia guttata"
xref: Reactome:REACT_114384 "Hydrolysis of eEF1A:GTP, Gallus gallus"
xref: Reactome:REACT_114532 "Formation of clathrin coated vesicle, Xenopus tropicalis"
xref: Reactome:REACT_114620 "Endocytosis (internalization) of clathrin-coated vesicle, Taeniopygia guttata"
xref: Reactome:REACT_114824 "trans-Golgi Network Lysosomal Vesicle Scission, Taeniopygia guttata"
xref: Reactome:REACT_115229 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Schizosaccharomyces pombe"
xref: Reactome:REACT_115324 "Endocytosis (internalization) of clathrin-coated vesicle, Bos taurus"
xref: Reactome:REACT_12396 "Loss of Sar1b GTPase, Homo sapiens"
xref: Reactome:REACT_12397 "Endocytosis (internalization) of clathrin-coated vesicle, Homo sapiens"
xref: Reactome:REACT_12456 "Vesicle Uncoating, Homo sapiens"
xref: Reactome:REACT_12612 "Endocytosis of clathrin-coated vesicle, Rattus norvegicus"
xref: Reactome:REACT_15316 "G-protein alpha subunit is inactivated, Homo sapiens"
xref: Reactome:REACT_15335 "Adenylate cyclase increases the GTPase activity of G alpha-olf, Homo sapiens"
xref: Reactome:REACT_15449 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Homo sapiens"
xref: Reactome:REACT_15495 "Adenylate cyclase increases the GTPase activity of Gi alpha, Homo sapiens"
xref: Reactome:REACT_19123 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Homo sapiens"
xref: Reactome:REACT_19178 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP, Homo sapiens"
xref: Reactome:REACT_19186 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Homo sapiens"
xref: Reactome:REACT_19194 "trans-Golgi Network Lysosomal Vesicle Scission, Homo sapiens"
xref: Reactome:REACT_19219 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP, Homo sapiens"
xref: Reactome:REACT_19255 "trans-Golgi Network Vesicle Scission, Homo sapiens"
xref: Reactome:REACT_19317 "G alpha (i)1 auto-inactivates by hydrolysing GTP to GDP, Rattus norvegicus"
xref: Reactome:REACT_22359 "Formation of clathrin coated vesicle, Homo sapiens"
xref: Reactome:REACT_28065 "Vesicle Uncoating, Sus scrofa"
xref: Reactome:REACT_28251 "Hydrolysis of eEF1A:GTP, Danio rerio"
xref: Reactome:REACT_28269 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Gallus gallus"
xref: Reactome:REACT_29162 "trans-Golgi Network Lysosomal Vesicle Scission, Mus musculus"
xref: Reactome:REACT_30456 "Hydrolysis of eEF1A:GTP, Plasmodium falciparum"
xref: Reactome:REACT_30463 "Adenylate cyclase increases the GTPase activity of G alpha-olf, Bos taurus"
xref: Reactome:REACT_30562 "Endocytosis (internalization) of clathrin-coated vesicle, Caenorhabditis elegans"
xref: Reactome:REACT_30687 "G-protein alpha subunit is inactivated, Xenopus tropicalis"
xref: Reactome:REACT_30707 "trans-Golgi Network Vesicle Scission, Caenorhabditis elegans"
xref: Reactome:REACT_30942 "Vesicle Uncoating, Rattus norvegicus"
xref: Reactome:REACT_31226 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Mus musculus"
xref: Reactome:REACT_31474 "Formation of clathrin coated vesicle, Danio rerio"
xref: Reactome:REACT_31530 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Caenorhabditis elegans"
xref: Reactome:REACT_31599 "trans-Golgi Network Lysosomal Vesicle Scission, Danio rerio"
xref: Reactome:REACT_31709 "Hydrolysis of eEF1A:GTP, Drosophila melanogaster"
xref: Reactome:REACT_31727 "Adenylate cyclase increases the GTPase activity of G alpha-olf, Taeniopygia guttata"
xref: Reactome:REACT_31850 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Gallus gallus"
xref: Reactome:REACT_32006 "Loss of Sar1b GTPase, Canis familiaris"
xref: Reactome:REACT_32028 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Danio rerio"
xref: Reactome:REACT_32914 "Vesicle Uncoating, Dictyostelium discoideum"
xref: Reactome:REACT_33948 "trans-Golgi Network Lysosomal Vesicle Scission, Rattus norvegicus"
xref: Reactome:REACT_34113 "Vesicle Uncoating, Schizosaccharomyces pombe"
xref: Reactome:REACT_34480 "G-protein alpha subunit is inactivated, Caenorhabditis elegans"
xref: Reactome:REACT_34592 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP, Xenopus tropicalis"
xref: Reactome:REACT_34735 "Adenylate cyclase increases the GTPase activity of Gi alpha, Taeniopygia guttata"
xref: Reactome:REACT_348 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Homo sapiens"
xref: Reactome:REACT_36834 "trans-Golgi Network Lysosomal Vesicle Scission, Bos taurus"
xref: Reactome:REACT_37542 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP, Sus scrofa"
xref: Reactome:REACT_552 "Hydrolysis of eEF1A:GTP, Homo sapiens"
xref: Reactome:REACT_6171 "Hydrolysis of Ran:GTP to Ran:GDP, Homo sapiens"
xref: Reactome:REACT_712 "Hydrolysis of reEF1A:GTP, Oryctolagus cuniculus"
xref: Reactome:REACT_75799 "Disassembly of COPII coated vesicle, Homo sapiens"
xref: Reactome:REACT_77032 "Hydrolysis of eEF1A:GTP, Canis familiaris"
xref: Reactome:REACT_77303 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Danio rerio"
xref: Reactome:REACT_78069 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Caenorhabditis elegans"
xref: Reactome:REACT_78231 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Taeniopygia guttata"
xref: Reactome:REACT_78653 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Bos taurus"
xref: Reactome:REACT_78945 "G-protein alpha subunit is inactivated, Rattus norvegicus"
xref: Reactome:REACT_79558 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP, Taeniopygia guttata"
xref: Reactome:REACT_79620 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Mus musculus"
xref: Reactome:REACT_80275 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Bos taurus"
xref: Reactome:REACT_80612 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Canis familiaris"
xref: Reactome:REACT_81304 "Loss of Sar1b GTPase, Taeniopygia guttata"
xref: Reactome:REACT_81448 "Endocytosis (internalization) of clathrin-coated vesicle, Canis familiaris"
xref: Reactome:REACT_81580 "Disassembly of COPII coated vesicle, Mus musculus"
xref: Reactome:REACT_81664 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Caenorhabditis elegans"
xref: Reactome:REACT_81879 "Vesicle Uncoating, Drosophila melanogaster"
xref: Reactome:REACT_82203 "Formation of clathrin coated vesicle, Canis familiaris"
xref: Reactome:REACT_82263 "G-protein alpha subunit is inactivated, Taeniopygia guttata"
xref: Reactome:REACT_82457 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Taeniopygia guttata"
xref: Reactome:REACT_82603 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Canis familiaris"
xref: Reactome:REACT_82704 "Loss of Sar1b GTPase, Rattus norvegicus"
xref: Reactome:REACT_83308 "Adenylate cyclase increases the GTPase activity of G alpha-olf, Rattus norvegicus"
xref: Reactome:REACT_83403 "G-protein alpha subunit is inactivated, Drosophila melanogaster"
xref: Reactome:REACT_83440 "Hydrolysis of eEF1A:GTP, Schizosaccharomyces pombe"
xref: Reactome:REACT_83730 "Loss of Sar1b GTPase, Plasmodium falciparum"
xref: Reactome:REACT_84204 "Endocytosis (internalization) of clathrin-coated vesicle, Danio rerio"
xref: Reactome:REACT_84553 "Vesicle Uncoating, Canis familiaris"
xref: Reactome:REACT_84696 "G-protein alpha subunit is inactivated, Danio rerio"
xref: Reactome:REACT_84712 "Hydrolysis of eEF1A:GTP, Saccharomyces cerevisiae"
xref: Reactome:REACT_84735 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Rattus norvegicus"
xref: Reactome:REACT_85008 "Vesicle Uncoating, Danio rerio"
xref: Reactome:REACT_85418 "Loss of Sar1b GTPase, Gallus gallus"
xref: Reactome:REACT_85769 "Disassembly of COPII coated vesicle, Danio rerio"
xref: Reactome:REACT_85972 "Adenylate cyclase increases the GTPase activity of G alpha-olf, Canis familiaris"
xref: Reactome:REACT_86227 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Dictyostelium discoideum"
xref: Reactome:REACT_86358 "trans-Golgi Network Lysosomal Vesicle Scission, Caenorhabditis elegans"
xref: Reactome:REACT_86400 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Dictyostelium discoideum"
xref: Reactome:REACT_86630 "Vesicle Uncoating, Mus musculus"
xref: Reactome:REACT_86760 "Adenylate cyclase increases the GTPase activity of G alpha-olf, Gallus gallus"
xref: Reactome:REACT_86972 "Loss of Sar1b GTPase, Mus musculus"
xref: Reactome:REACT_87409 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP, Dictyostelium discoideum"
xref: Reactome:REACT_87506 "Formation of clathrin coated vesicle, Rattus norvegicus"
xref: Reactome:REACT_87558 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP, Mus musculus"
xref: Reactome:REACT_87653 "Endocytosis (internalization) of clathrin-coated vesicle, Mus musculus"
xref: Reactome:REACT_87661 "Formation of clathrin coated vesicle, Drosophila melanogaster"
xref: Reactome:REACT_88045 "Vesicle Uncoating, Gallus gallus"
xref: Reactome:REACT_88357 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP, Canis familiaris"
xref: Reactome:REACT_89231 "Loss of Sar1b GTPase, Bos taurus"
xref: Reactome:REACT_89292 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Gallus gallus"
xref: Reactome:REACT_89416 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP, Bos taurus"
xref: Reactome:REACT_89668 "trans-Golgi Network Lysosomal Vesicle Scission, Xenopus tropicalis"
xref: Reactome:REACT_89763 "Vesicle Uncoating, Taeniopygia guttata"
xref: Reactome:REACT_90050 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Mus musculus"
xref: Reactome:REACT_90064 "Hydrolysis of eEF1A:GTP, Mus musculus"
xref: Reactome:REACT_90517 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Xenopus tropicalis"
xref: Reactome:REACT_90703 "G-protein alpha subunit is inactivated, Dictyostelium discoideum"
xref: Reactome:REACT_91199 "Adenylate cyclase increases the GTPase activity of Gi alpha, Bos taurus"
xref: Reactome:REACT_91588 "trans-Golgi Network Vesicle Scission, Drosophila melanogaster"
xref: Reactome:REACT_92176 "Endocytosis (internalization) of clathrin-coated vesicle, Drosophila melanogaster"
xref: Reactome:REACT_92197 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Bos taurus"
xref: Reactome:REACT_92198 "Loss of Sar1b GTPase, Oryza sativa"
xref: Reactome:REACT_92450 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Danio rerio"
xref: Reactome:REACT_93249 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Dictyostelium discoideum"
xref: Reactome:REACT_93305 "Loss of Sar1b GTPase, Sus scrofa"
xref: Reactome:REACT_93641 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Gallus gallus"
xref: Reactome:REACT_93742 "G-protein alpha subunit is inactivated, Mus musculus"
xref: Reactome:REACT_93772 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP, Gallus gallus"
xref: Reactome:REACT_94019 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Sus scrofa"
xref: Reactome:REACT_94095 "trans-Golgi Network Vesicle Scission, Sus scrofa"
xref: Reactome:REACT_94305 "Adenylate cyclase increases the GTPase activity of Gi alpha, Xenopus tropicalis"
xref: Reactome:REACT_94760 "Adenylate cyclase increases the GTPase activity of Gi alpha, Danio rerio"
xref: Reactome:REACT_95238 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Rattus norvegicus"
xref: Reactome:REACT_95563 "Adenylate cyclase increases the GTPase activity of Gi alpha, Canis familiaris"
xref: Reactome:REACT_96019 "Loss of Sar1b GTPase, Drosophila melanogaster"
xref: Reactome:REACT_96132 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Drosophila melanogaster"
xref: Reactome:REACT_96223 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP, Sus scrofa"
xref: Reactome:REACT_96612 "Adenylate cyclase increases the GTPase activity of Gi alpha, Rattus norvegicus"
xref: Reactome:REACT_96881 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Xenopus tropicalis"
xref: Reactome:REACT_97284 "Loss of Sar1b GTPase, Saccharomyces cerevisiae"
xref: Reactome:REACT_97405 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Taeniopygia guttata"
xref: Reactome:REACT_97595 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP, Danio rerio"
xref: Reactome:REACT_97794 "Loss of Sar1b GTPase, Schizosaccharomyces pombe"
xref: Reactome:REACT_98431 "Formation of clathrin coated vesicle, Caenorhabditis elegans"
xref: Reactome:REACT_98556 "Vesicle Uncoating, Bos taurus"
xref: Reactome:REACT_98837 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP, Canis familiaris"
xref: Reactome:REACT_98859 "Adenylate cyclase increases the GTPase activity of Gi alpha, Mus musculus"
xref: Reactome:REACT_99479 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Mus musculus"
xref: Reactome:REACT_99533 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Sus scrofa"
xref: Reactome:REACT_99616 "Formation of clathrin coated vesicle, Mus musculus"
xref: RHEA:19672
is_a: GO:0017111 ! nucleoside-triphosphatase activity

[Term]
id: GO:0003925
name: obsolete small monomeric GTPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. Small monomeric enzymes with a molecular mass of 21 kDa that are distantly related to the alpha-subunit of heterotrimeric G-protein GTPase. They are involved in cell-growth regulation (RAS subfamily), membrane vesicle traffic and uncoating (RAB and ARF subfamilies), nuclear protein import (RAN subfamily) and organization of the cytoskeleton (Rho and Rac subfamilies)." [EC:3.6.5.2, GOC:mah, ISBN:0198547684, MetaCyc:3.6.1.47-RXN]
comment: This term was made obsolete because it represents a gene product and contains cellular component information.
synonym: "small monomeric GTPase activity" EXACT []
is_obsolete: true
replaced_by: GO:0003924

[Term]
id: GO:0003926
name: obsolete ARF small monomeric GTPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47]
comment: This term was made obsolete because it represents a gene product.
synonym: "ARF small monomeric GTPase activity" EXACT []
is_obsolete: true
replaced_by: GO:0003924
consider: GO:0016191
consider: GO:0016192

[Term]
id: GO:0003927
name: obsolete heterotrimeric G-protein GTPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. GTP-hydrolyzing enzymes, where GTP and GDP alternate in binding. Includes stimulatory and inhibitory G-proteins such as Gs, Gi, Go and Golf, targeting adenylate cyclase and/or potassium ion and calcium ion channels; Gq stimulating phospholipase C; transducin activating cGMP phosphodiesterase; gustducin activating cAMP phosphodiesterase." [EC:3.6.5.1, ISBN:0198547684, MetaCyc:3.6.1.46-RXN]
comment: This term was made obsolete because it represents a cellular component.
synonym: "heterotrimeric G-protein GTPase activity" EXACT []
is_obsolete: true
consider: GO:0003924
consider: GO:0005834

[Term]
id: GO:0003928
name: obsolete RAB small monomeric GTPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47]
comment: This term was made obsolete because it represents a gene product.
synonym: "RAB small monomeric GTPase activity" EXACT []
is_obsolete: true
replaced_by: GO:0003924
consider: GO:0016191
consider: GO:0016192

[Term]
id: GO:0003929
name: obsolete RAN small monomeric GTPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47]
comment: This term was made obsolete because it represents a gene product.
synonym: "RAN small monomeric GTPase activity" EXACT []
is_obsolete: true
replaced_by: GO:0003924
consider: GO:0006606

[Term]
id: GO:0003930
name: obsolete RAS small monomeric GTPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47]
comment: This term was made obsolete because it represents a gene product.
synonym: "RAS small monomeric GTPase activity" EXACT []
is_obsolete: true
replaced_by: GO:0003924
consider: GO:0001558

[Term]
id: GO:0003931
name: obsolete Rho small monomeric GTPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. Any member of the Rho subfamily of the RAS superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton." [EC:3.6.1.47, GOC:mah, ISBN:0198547684]
comment: This term was made obsolete because it represents a gene product.
synonym: "Rho small monomeric GTPase activity" EXACT []
is_obsolete: true
replaced_by: GO:0003924
consider: GO:0007010

[Term]
id: GO:0003932
name: obsolete SAR small monomeric GTPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47]
comment: This term was made obsolete because it represents a gene product.
synonym: "SAR small monomeric GTPase activity" EXACT []
is_obsolete: true
replaced_by: GO:0003924
consider: GO:0046903

[Term]
id: GO:0003933
name: GTP cyclohydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the imidazole ring of GTP, releasing formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized." [EC:3.5.4.16, EC:3.5.4.25, EC:3.5.4.29, GOC:curators]
subset: gosubset_prok
xref: EC:3.5.4.-
is_a: GO:0019238 ! cyclohydrolase activity

[Term]
id: GO:0003934
name: GTP cyclohydrolase I activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate." [EC:3.5.4.16]
subset: gosubset_prok
synonym: "dihydroneopterin triphosphate synthase activity" EXACT [EC:3.5.4.16]
synonym: "GTP 7,8-8,9-dihydrolase activity" EXACT [EC:3.5.4.16]
synonym: "GTP 8-formylhydrolase activity" EXACT [EC:3.5.4.16]
synonym: "guanosine triphosphate 8-deformylase activity" EXACT [EC:3.5.4.16]
synonym: "guanosine triphosphate cyclohydrolase activity" EXACT [EC:3.5.4.16]
xref: EC:3.5.4.16
xref: KEGG:R00424
xref: MetaCyc:GTP-CYCLOHYDRO-I-RXN
xref: Reactome:REACT_111143 "GCH1 reduces GTP to dihydroneopterin triphosphate, Homo sapiens"
xref: RHEA:17476
is_a: GO:0003933 ! GTP cyclohydrolase activity

[Term]
id: GO:0003935
name: GTP cyclohydrolase II activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP + 3 H(2)O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + diphosphate + formate + 3 H(+)." [EC:3.5.4.25, RHEA:23707]
subset: gosubset_prok
synonym: "GTP 7,8-8,9-dihydrolase (diphosphate-forming)" EXACT [EC:3.5.4.25]
synonym: "GTP-8-formylhydrolase activity" EXACT [EC:3.5.4.25]
synonym: "guanosine triphosphate cyclohydrolase II" RELATED [EC:3.5.4.25]
xref: EC:3.5.4.25
xref: KEGG:R00425
xref: MetaCyc:GTP-CYCLOHYDRO-II-RXN
xref: RHEA:23707
is_a: GO:0003933 ! GTP cyclohydrolase activity

[Term]
id: GO:0003936
name: obsolete hydrogen-transporting two-sector ATPase activity
namespace: molecular_function
alt_id: GO:0004006
alt_id: GO:0008729
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)." [EC:3.6.3.14, TC:3.A.3.-.-]
comment: This term was made obsolete because it refers to a bifunctional gene product.
synonym: "hydrogen-transporting two-sector ATPase activity" EXACT []
synonym: "proton-transporting two-sector ATPase activity" EXACT []
is_obsolete: true
consider: GO:0046933
consider: GO:0046961

[Term]
id: GO:0003937
name: IMP cyclohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: IMP + H2O = 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide." [EC:3.5.4.10]
subset: gosubset_prok
synonym: "IMP 1,2-hydrolase (decyclizing)" EXACT [EC:3.5.4.10]
synonym: "IMP synthetase activity" EXACT [EC:3.5.4.10]
synonym: "inosinate cyclohydrolase activity" EXACT [EC:3.5.4.10]
synonym: "inosinicase activity" EXACT [EC:3.5.4.10]
xref: EC:3.5.4.10
xref: MetaCyc:IMPCYCLOHYDROLASE-RXN
xref: Reactome:REACT_100264 "FAICAR => IMP + H2O, Mycobacterium tuberculosis"
xref: Reactome:REACT_101327 "FAICAR => IMP + H2O, Oryza sativa"
xref: Reactome:REACT_101441 "FAICAR => IMP + H2O, Canis familiaris"
xref: Reactome:REACT_101852 "FAICAR => IMP + H2O, Caenorhabditis elegans"
xref: Reactome:REACT_105279 "FAICAR => IMP + H2O, Danio rerio"
xref: Reactome:REACT_107619 "FAICAR => IMP + H2O, Rattus norvegicus"
xref: Reactome:REACT_110740 "FAICAR => IMP + H2O, Gallus gallus"
xref: Reactome:REACT_116131 "5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) <=> inosine 5'-monophosphate + H2O, Gallus gallus"
xref: Reactome:REACT_263 "FAICAR => IMP + H2O, Homo sapiens"
xref: Reactome:REACT_29038 "FAICAR => IMP + H2O, Xenopus tropicalis"
xref: Reactome:REACT_30340 "FAICAR => IMP + H2O, Bos taurus"
xref: Reactome:REACT_30737 "FAICAR => IMP + H2O, Arabidopsis thaliana"
xref: Reactome:REACT_79659 "FAICAR => IMP + H2O, Schizosaccharomyces pombe"
xref: Reactome:REACT_80364 "FAICAR => IMP + H2O, Dictyostelium discoideum"
xref: Reactome:REACT_80795 "FAICAR => IMP + H2O, Sus scrofa"
xref: Reactome:REACT_80881 "FAICAR => IMP + H2O, Mus musculus"
xref: Reactome:REACT_83814 "FAICAR => IMP + H2O, Drosophila melanogaster"
xref: Reactome:REACT_93074 "FAICAR => IMP + H2O, Escherichia coli"
xref: Reactome:REACT_93482 "FAICAR => IMP + H2O, Taeniopygia guttata"
xref: Reactome:REACT_94292 "FAICAR => IMP + H2O, Staphylococcus aureus N315"
xref: Reactome:REACT_98029 "FAICAR => IMP + H2O, Saccharomyces cerevisiae"
xref: RHEA:18448
is_a: GO:0019238 ! cyclohydrolase activity

[Term]
id: GO:0003938
name: IMP dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+." [EC:1.1.1.205]
subset: gosubset_prok
synonym: "IMP oxidoreductase activity" EXACT [EC:1.1.1.205]
synonym: "IMP:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.205]
synonym: "inosinate dehydrogenase activity" RELATED [EC:1.1.1.205]
synonym: "inosine 5'-monophosphate dehydrogenase activity" EXACT [EC:1.1.1.205]
synonym: "inosine monophosphate dehydrogenase activity" EXACT [EC:1.1.1.205]
synonym: "inosine monophosphate oxidoreductase activity" EXACT [EC:1.1.1.205]
synonym: "inosine-5'-phosphate dehydrogenase activity" EXACT [EC:1.1.1.205]
synonym: "inosinic acid dehydrogenase activity" RELATED [EC:1.1.1.205]
xref: EC:1.1.1.205
xref: MetaCyc:IMP-DEHYDROG-RXN
xref: Reactome:REACT_102501 "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2], Dictyostelium discoideum"
xref: Reactome:REACT_110875 "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2], Taeniopygia guttata"
xref: Reactome:REACT_116090 "inosine 5'-monophosphate (IMP) + NAD+ + H2O => xanthosine 5'-monophosphate (XMP) + NADH + H+, Gallus gallus"
xref: Reactome:REACT_1488 "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2], Homo sapiens"
xref: Reactome:REACT_31646 "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2], Gallus gallus"
xref: Reactome:REACT_32201 "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2], Escherichia coli"
xref: Reactome:REACT_33579 "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2], Schizosaccharomyces pombe"
xref: Reactome:REACT_33597 "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2], Staphylococcus aureus N315"
xref: Reactome:REACT_33701 "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2], Plasmodium falciparum"
xref: Reactome:REACT_77612 "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2], Mycobacterium tuberculosis"
xref: Reactome:REACT_79622 "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2], Xenopus tropicalis"
xref: Reactome:REACT_80105 "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2], Drosophila melanogaster"
xref: Reactome:REACT_86742 "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2], Danio rerio"
xref: Reactome:REACT_86832 "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2], Bos taurus"
xref: Reactome:REACT_88830 "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2], Canis familiaris"
xref: Reactome:REACT_94520 "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2], Sus scrofa"
xref: Reactome:REACT_94662 "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2], Rattus norvegicus"
xref: Reactome:REACT_96045 "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2], Oryza sativa"
xref: Reactome:REACT_96517 "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2], Caenorhabditis elegans"
xref: Reactome:REACT_96945 "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2], Arabidopsis thaliana"
xref: Reactome:REACT_97319 "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2], Mus musculus"
xref: Reactome:REACT_98553 "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2], Saccharomyces cerevisiae"
xref: RHEA:11711
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0003939
name: L-iditol 2-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-iditol + NAD+ = L-sorbose + NADH + H+." [EC:1.1.1.14]
comment: Note that enzymes with this activity also act on D-glucitol (giving D-fructose) and other closely related sugar alcohols.
subset: gosubset_prok
synonym: "glucitol dehydrogenase activity" RELATED [EC:1.1.1.14]
synonym: "L-iditol (sorbitol) dehydrogenase activity" RELATED [EC:1.1.1.14]
synonym: "L-iditol:NAD oxidoreductase activity" EXACT [EC:1.1.1.14]
synonym: "L-iditol:NAD+ 5-oxidoreductase activity" EXACT [EC:1.1.1.14]
synonym: "NAD+-dependent sorbitol dehydrogenase activity" RELATED [EC:1.1.1.14]
synonym: "NAD-dependent sorbitol dehydrogenase activity" RELATED [EC:1.1.1.14]
synonym: "NAD-sorbitol dehydrogenase" RELATED [EC:1.1.1.14]
synonym: "polyol dehydrogenase activity" BROAD [EC:1.1.1.14]
synonym: "sorbitol dehydrogenase activity" RELATED [EC:1.1.1.14]
xref: EC:1.1.1.14
xref: MetaCyc:L-IDITOL-2-DEHYDROGENASE-RXN
xref: RHEA:10163
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0003940
name: L-iduronidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of alpha-L-iduronosidic linkages in dermatan sulfate." [EC:3.2.1.76]
synonym: "alpha-L-iduronidase activity" EXACT [EC:3.2.1.76]
synonym: "glycosaminoglycan alpha-L-iduronohydrolase activity" EXACT [EC:3.2.1.76]
xref: EC:3.2.1.76
xref: MetaCyc:3.2.1.76-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0003941
name: L-serine ammonia-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-serine = pyruvate + NH3." [EC:4.3.1.17]
comment: Note that this function was formerly EC:4.3.1.13.
subset: gosubset_prok
synonym: "L-hydroxyaminoacid dehydratase activity" BROAD []
synonym: "L-serine ammonia-lyase (pyruvate-forming) activity" EXACT [EC:4.3.1.17]
synonym: "L-serine deaminase activity" EXACT []
synonym: "L-serine dehydratase activity" BROAD [EC:4.3.1.17]
synonym: "L-serine hydro-lyase (deaminating) activity" EXACT []
synonym: "serine deaminase activity" BROAD [EC:4.3.1.17]
xref: EC:4.3.1.17
xref: MetaCyc:4.3.1.17-RXN
xref: RHEA:19172
is_a: GO:0016841 ! ammonia-lyase activity

[Term]
id: GO:0003942
name: N-acetyl-gamma-glutamyl-phosphate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH + H+." [EC:1.2.1.38]
subset: gosubset_prok
synonym: "N-acetyl-glutamate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.38]
synonym: "N-acetyl-L-glutamate gamma-semialdehyde:NADP oxidoreductase (phosphorylating)" EXACT [EC:1.2.1.38]
synonym: "N-acetyl-L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)" EXACT [EC:1.2.1.38]
synonym: "N-acetylglutamate 5-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.38]
synonym: "N-acetylglutamic gamma-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.38]
synonym: "NAGSA dehydrogenase activity" BROAD [EC:1.2.1.38]
synonym: "reductase, acetyl-gamma-glutamyl phosphate" EXACT [EC:1.2.1.38]
xref: EC:1.2.1.38
xref: MetaCyc:N-ACETYLGLUTPREDUCT-RXN
xref: RHEA:21591
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0003943
name: N-acetylgalactosamine-4-sulfatase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate." [EC:3.1.6.12]
subset: gosubset_prok
synonym: "acetylgalactosamine 4-sulfatase activity" EXACT [EC:3.1.6.12]
synonym: "arylsulfatase B" EXACT []
synonym: "chondroitinsulfatase" BROAD [EC:3.1.6.12]
synonym: "N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase activity" EXACT [EC:3.1.6.12]
synonym: "N-acetylgalactosamine 4-sulfate sulfohydrolase activity" EXACT [EC:3.1.6.12]
synonym: "N-acetylgalactosamine-4-sulphatase activity" EXACT []
xref: EC:3.1.6.12
xref: MetaCyc:3.1.6.12-RXN
xref: Wikipedia:Arylsulfatase_B
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0003944
name: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H2O = N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose." [EC:3.1.4.45]
synonym: "2-acetamido-2-deoxy-alpha-D-glucose 1-phosphodiester acetamidodeoxyglucohydrolase activity" EXACT [EC:3.1.4.45]
synonym: "alpha-N-acetyl-D-glucosamine-1-phosphodiester N-acetylglucosaminidase activity" EXACT [EC:3.1.4.45]
synonym: "alpha-N-acetylglucosaminyl phosphodiesterase activity" EXACT [EC:3.1.4.45]
synonym: "glycoprotein-N-acetyl-D-glucosaminyl-phospho-D-mannose N-acetyl-D-glucosaminylphosphohydrolase activity" EXACT [EC:3.1.4.45]
synonym: "lysosomal alpha-N-acetylglucosaminidase activity" NARROW [EC:3.1.4.45]
synonym: "phosphodiester glycosidase activity" EXACT [EC:3.1.4.45]
xref: EC:3.1.4.45
xref: MetaCyc:3.1.4.45-RXN
is_a: GO:0015929 ! hexosaminidase activity

[Term]
id: GO:0003945
name: N-acetyllactosamine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine." [EC:2.4.1.90]
subset: gosubset_prok
synonym: "acetyllactosamine synthetase activity" EXACT [EC:2.4.1.90]
synonym: "beta-(1,4)-galactosyltransferase activity" EXACT [EC:2.4.1.90]
synonym: "beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.90]
synonym: "beta-1,4-GalT" RELATED [EC:2.4.1.90]
synonym: "beta-N-acetylglucosaminide beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.90]
synonym: "Gal-T" RELATED [EC:2.4.1.90]
synonym: "lactosamine synthase activity" EXACT [EC:2.4.1.90]
synonym: "lactosamine synthetase activity" EXACT [EC:2.4.1.90]
synonym: "lactose synthetase A protein" RELATED [EC:2.4.1.90]
synonym: "N-acetylglucosamine (beta-1,4)galactosyltransferase activity" EXACT [EC:2.4.1.90]
synonym: "N-acetylglucosamine beta-(1,4)-galactosyltransferase activity" EXACT [EC:2.4.1.90]
synonym: "N-acetyllactosamine synthetase activity" EXACT [EC:2.4.1.90]
synonym: "NAL synthetase activity" EXACT [EC:2.4.1.90]
synonym: "UDP-beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.90]
synonym: "UDP-Gal:N-acetylglucosamine beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.90]
synonym: "UDP-galactose N-acetylglucosamine beta-4-galactosyltransferase activity" EXACT [EC:2.4.1.90]
synonym: "UDP-galactose-acetylglucosamine galactosyltransferase activity" EXACT [EC:2.4.1.90]
synonym: "UDP-galactose-N-acetylglucosamine beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.90]
synonym: "UDP-galactose-N-acetylglucosamine beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.90]
synonym: "UDP-galactose-N-acetylglucosamine galactosyltransferase activity" EXACT [EC:2.4.1.90]
synonym: "UDP-galactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase activity" EXACT []
synonym: "UDP-galactose:N-acetylglucosaminide beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.90]
synonym: "UDPgalactose-N-acetylglucosamine beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.90]
synonym: "UDPgalactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.90]
synonym: "UDPgalactose:N-acetylglucosaminyl(beta-1,4)galactosyltransferase activity" EXACT [EC:2.4.1.90]
synonym: "uridine diphosphogalactose-acetylglucosamine galactosyltransferase activity" EXACT [EC:2.4.1.90]
xref: EC:2.4.1.90
xref: MetaCyc:N-ACETYLLACTOSAMINE-SYNTHASE-RXN
xref: RHEA:17748
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0003947
name: (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide = UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide." [EC:2.4.1.92]
synonym: "asialo-GM2 synthase activity" EXACT [EC:2.4.1.92]
synonym: "beta-1,4N-aetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92]
synonym: "GalNAc-T activity" EXACT [EC:2.4.1.92]
synonym: "ganglioside GM2 synthase activity" EXACT [EC:2.4.1.92]
synonym: "ganglioside GM3 acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92]
synonym: "GM2 synthase activity" EXACT [EC:2.4.1.92]
synonym: "GM2/GD2-synthase activity" EXACT [EC:2.4.1.92]
synonym: "UDP acetylgalactosamine-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92]
synonym: "UDP-N-acetyl-D-galactosamine:(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide N-acetyl-D-galactosaminyltransferase activity" EXACT [EC:2.4.1.92]
synonym: "UDP-N-acetyl-D-galactosamine:1-O-[O-(N-acetyl-alpha-neuraminosyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]-ceramide 1,4-beta-N-acetyl-D-galactosaminyltransferase activity" EXACT [EC:2.4.1.92]
synonym: "UDP-N-acetylgalactosamine GM3 N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92]
synonym: "uridine diphosphoacetylgalactosamine-acetylneuraminylgalactosylglucosylceramide acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92]
synonym: "uridine diphosphoacetylgalactosamine-ganglioside GM3 acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92]
synonym: "uridine diphosphoacetylgalactosamine-hematoside acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92]
xref: EC:2.4.1.92
xref: MetaCyc:2.4.1.92-RXN
xref: RHEA:12591
is_a: GO:0008376 ! acetylgalactosaminyltransferase activity

[Term]
id: GO:0003948
name: N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity
namespace: molecular_function
def: "Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H(2)O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)." [EC:3.5.1.26, RHEA:11547]
subset: gosubset_prok
synonym: "4-N-(beta-N-acetyl-D-glucosaminyl)-L-asparagine amidohydrolase activity" EXACT [EC:3.5.1.26]
synonym: "aspartylglucosaminidase activity" EXACT [EC:3.5.1.26]
synonym: "aspartylglucosylaminase activity" EXACT [EC:3.5.1.26]
synonym: "aspartylglucosylamine deaspartylase activity" EXACT [EC:3.5.1.26]
synonym: "aspartylglucosylaminidase activity" EXACT [EC:3.5.1.26]
synonym: "aspartylglycosylamine amidohydrolase activity" EXACT [EC:3.5.1.26]
synonym: "beta-aspartylglucosylamine amidohydrolase activity" EXACT [EC:3.5.1.26]
synonym: "glucosylamidase activity" RELATED [EC:3.5.1.26]
synonym: "glycosylasparaginase activity" EXACT [EC:3.5.1.26]
synonym: "N-aspartyl-beta-glucosaminidase activity" EXACT [EC:3.5.1.26]
synonym: "N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine amidohydrolase activity" EXACT [EC:3.5.1.26]
xref: EC:3.5.1.26
xref: KEGG:R03421
xref: MetaCyc:3.5.1.26-RXN
xref: RHEA:11547
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0003949
name: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide." [EC:5.3.1.16, RHEA:15472]
subset: gosubset_prok
synonym: "1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide aldose-ketose-isomerase activity" EXACT [EC:5.3.1.16]
synonym: "1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide ketol-isomerase activity" EXACT [EC:5.3.1.16]
synonym: "N-(5'-phospho-D-ribosylformimino)-5-amino-1-(5''-phosphoribosyl)-4-imidazolecarboxamide isomerase activity" EXACT [EC:5.3.1.16]
synonym: "N-(phosphoribosylformimino) aminophosphoribosylimidazolecarboxamide isomerase activity" EXACT [EC:5.3.1.16]
synonym: "phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase activity" EXACT [EC:5.3.1.16]
synonym: "phosphoribosylformiminoaminophosphoribosylimidazolecarboxamide isomerase activity" EXACT [EC:5.3.1.16]
xref: EC:5.3.1.16
xref: KEGG:R04640
xref: MetaCyc:PRIBFAICARPISOM-RXN
xref: RHEA:15472
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0003950
name: NAD+ ADP-ribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30]
subset: gosubset_prok
synonym: "ADP-ribosyltransferase (polymerizing) activity" EXACT [EC:2.4.2.30]
synonym: "NAD ADP-ribosyltransferase activity" EXACT []
synonym: "NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" EXACT [EC:2.4.2.30]
synonym: "poly(adenosine diphosphate ribose) polymerase activity" EXACT [EC:2.4.2.30]
synonym: "poly(ADP-ribose) synthase activity" EXACT [EC:2.4.2.30]
synonym: "poly(ADP-ribose) synthetase activity" EXACT [EC:2.4.2.30]
synonym: "poly(ADP-ribose)polymerase activity" EXACT [EC:2.4.2.30]
xref: EC:2.4.2.30
xref: MetaCyc:NAD+-ADP-RIBOSYLTRANSFERASE-RXN
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0003951
name: NAD+ kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + NAD(+) = ADP + 2 H(+) + NADP(+)." [EC:2.7.1.23, RHEA:18632]
subset: gosubset_prok
synonym: "ATP:NAD+ 2'-phosphotransferase activity" EXACT [EC:2.7.1.23]
synonym: "DPN kinase activity" RELATED [EC:2.7.1.23]
synonym: "NAD kinase activity" EXACT []
synonym: "NADK" RELATED [EC:2.7.1.23]
synonym: "nicotinamide adenine dinucleotide kinase (phosphorylating)" EXACT [EC:2.7.1.23]
synonym: "nicotinamide adenine dinucleotide kinase activity" EXACT [EC:2.7.1.23]
xref: EC:2.7.1.23
xref: KEGG:R00104
xref: MetaCyc:NAD-KIN-RXN
xref: Reactome:REACT_100710 "NAD+ is phosphorylated to NADP+, Danio rerio"
xref: Reactome:REACT_102495 "NAD+ is phosphorylated to NADP+, Dictyostelium discoideum"
xref: Reactome:REACT_104124 "NAD+ is phosphorylated to NADP+, Arabidopsis thaliana"
xref: Reactome:REACT_105015 "NAD+ is phosphorylated to NADP+, Rattus norvegicus"
xref: Reactome:REACT_106084 "NAD+ is phosphorylated to NADP+, Mycobacterium tuberculosis"
xref: Reactome:REACT_106904 "NAD+ is phosphorylated to NADP+, Escherichia coli"
xref: Reactome:REACT_11234 "NAD+ is phosphorylated to NADP+, Homo sapiens"
xref: Reactome:REACT_28799 "NAD+ is phosphorylated to NADP+, Canis familiaris"
xref: Reactome:REACT_30450 "NAD+ is phosphorylated to NADP+, Gallus gallus"
xref: Reactome:REACT_32843 "NAD+ is phosphorylated to NADP+, Oryza sativa"
xref: Reactome:REACT_82142 "NAD+ is phosphorylated to NADP+, Xenopus tropicalis"
xref: Reactome:REACT_86304 "NAD+ is phosphorylated to NADP+, Mus musculus"
xref: Reactome:REACT_88716 "NAD+ is phosphorylated to NADP+, Taeniopygia guttata"
xref: Reactome:REACT_93050 "NAD+ is phosphorylated to NADP+, Bos taurus"
xref: Reactome:REACT_94691 "NAD+ is phosphorylated to NADP+, Drosophila melanogaster"
xref: RHEA:18632
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0003952
name: NAD+ synthase (glutamine-hydrolyzing) activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate." [EC:6.3.5.1]
subset: gosubset_prok
synonym: "deamido-NAD+:L-glutamine amido-ligase (AMP-forming)" EXACT [EC:6.3.5.1]
synonym: "desamidonicotinamide adenine dinucleotide amidotransferase activity" EXACT [EC:6.3.5.1]
synonym: "DPN synthetase activity" EXACT [EC:6.3.5.1]
synonym: "NAD synthase (glutamine-hydrolyzing) activity" EXACT []
synonym: "NAD synthetase (glutamine-hydrolysing)" EXACT [EC:6.3.5.1]
synonym: "NAD(+) synthetase (glutamine-hydrolyzing) activity" EXACT [EC:6.3.5.1]
synonym: "NAD+ synthase (glutamine-hydrolysing)" EXACT [EC:6.3.5.1]
synonym: "NAD+ synthetase (glutamine-hydrolyzing)" EXACT [EC:6.3.5.1]
synonym: "nicotinamide adenine dinucleotide synthetase (glutamine) activity" EXACT [EC:6.3.5.1]
xref: EC:6.3.5.1
xref: MetaCyc:NAD-SYNTH-GLN-RXN
xref: Reactome:REACT_101777 "Amidation of deamino-NAD+ to NAD+, Gallus gallus"
xref: Reactome:REACT_106358 "Amidation of deamino-NAD+ to NAD+, Taeniopygia guttata"
xref: Reactome:REACT_11135 "Amidation of deamino-NAD+ to NAD+, Homo sapiens"
xref: Reactome:REACT_112596 "Amidation of deamino-NAD+ to NAD+, Xenopus tropicalis"
xref: Reactome:REACT_33314 "Amidation of deamino-NAD+ to NAD+, Sus scrofa"
xref: Reactome:REACT_34274 "Amidation of deamino-NAD+ to NAD+, Plasmodium falciparum"
xref: Reactome:REACT_34563 "Amidation of deamino-NAD+ to NAD+, Oryza sativa"
xref: Reactome:REACT_78384 "Amidation of deamino-NAD+ to NAD+, Rattus norvegicus"
xref: Reactome:REACT_79027 "Amidation of deamino-NAD+ to NAD+, Danio rerio"
xref: Reactome:REACT_80179 "Amidation of deamino-NAD+ to NAD+, Mus musculus"
xref: Reactome:REACT_81822 "Amidation of deamino-NAD+ to NAD+, Arabidopsis thaliana"
xref: Reactome:REACT_84016 "Amidation of deamino-NAD+ to NAD+, Dictyostelium discoideum"
xref: Reactome:REACT_86176 "Amidation of deamino-NAD+ to NAD+, Saccharomyces cerevisiae"
xref: Reactome:REACT_86976 "Amidation of deamino-NAD+ to NAD+, Bos taurus"
xref: Reactome:REACT_90083 "Amidation of deamino-NAD+ to NAD+, Canis familiaris"
xref: Reactome:REACT_90698 "Amidation of deamino-NAD+ to NAD+, Drosophila melanogaster"
xref: Reactome:REACT_93162 "Amidation of deamino-NAD+ to NAD+, Mycobacterium tuberculosis"
xref: Reactome:REACT_98272 "Amidation of deamino-NAD+ to NAD+, Schizosaccharomyces pombe"
xref: Reactome:REACT_98584 "Amidation of deamino-NAD+ to NAD+, Caenorhabditis elegans"
xref: RHEA:24387
xref: Wikipedia:NAD+_synthase_(glutamine-hydrolysing)
is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor

[Term]
id: GO:0003953
name: NAD+ nucleosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose." [EC:3.2.2.5]
subset: gosubset_prok
synonym: "ADP-ribosyl cyclase activity" RELATED [EC:3.2.2.5]
synonym: "diphosphopyridine nucleosidase activity" EXACT [EC:3.2.2.5]
synonym: "DPN hydrolase activity" EXACT [EC:3.2.2.5]
synonym: "DPNase activity" EXACT [EC:3.2.2.5]
synonym: "NAD glycohydrolase activity" EXACT [EC:3.2.2.5]
synonym: "NAD hydrolase activity" EXACT [EC:3.2.2.5]
synonym: "NAD nucleosidase activity" EXACT []
synonym: "NAD+ glycohydrolase activity" EXACT [EC:3.2.2.5]
synonym: "NADase activity" EXACT [EC:3.2.2.5]
synonym: "nicotinamide adenine dinucleotide glycohydrolase activity" EXACT [EC:3.2.2.5]
synonym: "nicotinamide adenine dinucleotide nucleosidase activity" EXACT [EC:3.2.2.5]
xref: EC:3.2.2.5
xref: MetaCyc:NADNUCLEOSID-RXN
xref: RHEA:16304
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0003954
name: NADH dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor." [EC:1.6.99.3]
subset: gosubset_prok
synonym: "beta-NADH dehydrogenase dinucleotide activity" EXACT [EC:1.6.99.3]
synonym: "cytochrome c reductase activity" RELATED [EC:1.6.99.3]
synonym: "diaphorase activity" BROAD [EC:1.6.99.3]
synonym: "dihydrocodehydrogenase I dehydrogenase activity" EXACT [EC:1.6.99.3]
synonym: "dihydronicotinamide adenine dinucleotide dehydrogenase activity" EXACT [EC:1.6.99.3]
synonym: "diphosphopyridine diaphorase activity" EXACT [EC:1.6.99.3]
synonym: "diphosphopyrinase activity" EXACT [EC:1.6.99.3]
synonym: "DPNH diaphorase activity" EXACT [EC:1.6.99.3]
synonym: "NADH diaphorase activity" EXACT [EC:1.6.99.3]
synonym: "NADH hydrogenase activity" EXACT [EC:1.6.99.3]
synonym: "NADH oxidoreductase activity" EXACT [EC:1.6.99.3]
synonym: "NADH-menadione oxidoreductase activity" NARROW [EC:1.6.99.3]
synonym: "NADH2 dehydrogenase activity" EXACT [EC:1.6.99.3]
synonym: "NADH:(acceptor) oxidoreductase activity" EXACT [EC:1.6.99.3]
synonym: "NADH:acceptor oxidoreductase activity" EXACT [EC:1.6.99.3]
synonym: "NADH:cytochrome c oxidoreductase activity" NARROW [EC:1.6.99.3]
synonym: "reduced diphosphopyridine nucleotide diaphorase activity" EXACT [EC:1.6.99.3]
synonym: "type 1 dehydrogenase activity" RELATED [EC:1.6.99.3]
synonym: "type I dehydrogenase activity" RELATED [EC:1.6.99.3]
xref: EC:1.6.99.3
xref: MetaCyc:NADH-DEHYDROGENASE-RXN
xref: RHEA:11359
is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H

[Term]
id: GO:0003955
name: NAD(P)H dehydrogenase (quinone) activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(P)H + H+ + a quinone = NAD(P)+ + a hydroquinone." [EC:1.6.5.2]
subset: gosubset_prok
synonym: "azoreductase activity" BROAD [EC:1.6.5.2]
synonym: "dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate, quinone) activity" EXACT [EC:1.6.5.2]
synonym: "diaphorase activity" BROAD [EC:1.6.5.2]
synonym: "DT-diaphorase activity" EXACT [EC:1.6.5.2]
synonym: "flavoprotein NAD(P)H-quinone reductase activity" EXACT [EC:1.6.5.2]
synonym: "menadione oxidoreductase activity" NARROW [EC:1.6.5.2]
synonym: "menadione reductase activity" NARROW [EC:1.6.5.2]
synonym: "NAD(P)H dehydrogenase activity" EXACT [EC:1.6.5.2]
synonym: "NAD(P)H menadione reductase activity" BROAD [EC:1.6.5.2]
synonym: "NAD(P)H(2) dehydrogenase (quinone) activity" EXACT [EC:1.6.5.2]
synonym: "NAD(P)H-quinone dehydrogenase activity" EXACT [EC:1.6.5.2]
synonym: "NAD(P)H-quinone oxidoreductase activity" EXACT [EC:1.6.5.2]
synonym: "NAD(P)H2 dehydrogenase (quinone)" EXACT [EC:1.6.5.2]
synonym: "NAD(P)H: menadione oxidoreductase activity" BROAD [EC:1.6.5.2]
synonym: "NAD(P)H:(quinone-acceptor)oxidoreductase activity" EXACT [EC:1.6.5.2]
synonym: "NAD(P)H:quinone oxidoreductase activity" EXACT [EC:1.6.5.2]
synonym: "NADH-menadione reductase activity" NARROW [EC:1.6.5.2]
synonym: "Naphthoquinone reductase activity" NARROW [EC:1.6.5.2]
synonym: "naphthoquinone reductase activity" EXACT [EC:1.6.5.2]
synonym: "NQO1" RELATED [EC:1.6.5.2]
synonym: "p-benzoquinone reductase activity" NARROW [EC:1.6.5.2]
synonym: "phylloquinone reductase activity" NARROW [EC:1.6.5.2]
synonym: "QR1" RELATED [EC:1.6.5.2]
synonym: "quinone reductase activity" EXACT [EC:1.6.5.2]
synonym: "reduced NAD(P)H dehydrogenase activity" EXACT [EC:1.6.5.2]
synonym: "reduced nicotinamide-adenine dinucleotide (phosphate) dehydrogenase activity" EXACT [EC:1.6.5.2]
synonym: "viologen accepting pyridine nucleotide oxidoreductase activity" NARROW [EC:1.6.5.2]
synonym: "vitamin K reductase activity" NARROW [EC:1.6.5.2]
synonym: "vitamin-K reductase activity" NARROW [EC:1.6.5.2]
xref: EC:1.6.5.2
xref: MetaCyc:NQOR-RXN
xref: UM-BBD_reactionID:r0227
is_a: GO:0016655 ! oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor

[Term]
id: GO:0003956
name: NAD(P)+-protein-arginine ADP-ribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(P)+ + L-arginine = nicotinamide + N2-(ADP-D-ribosyl)-L-arginine." [EC:2.4.2.31]
synonym: "ADP-ribosyltransferase activity" BROAD [EC:2.4.2.31]
synonym: "mono(ADP-ribosyl)transferase activity" BROAD [EC:2.4.2.31]
synonym: "mono(ADPribosyl)transferase activity" BROAD [EC:2.4.2.31]
synonym: "NAD(+):L-arginine ADP-D-ribosyltransferase activity" EXACT [EC:2.4.2.31]
synonym: "NAD(P)(+)--arginine ADP-ribosyltransferase activity" EXACT [EC:2.4.2.31]
synonym: "NAD(P)+-arginine ADP-ribosyltransferase activity" EXACT []
synonym: "NAD(P)+:L-arginine ADP-D-ribosyltransferase activity" EXACT [EC:2.4.2.31]
synonym: "NAD(P)+:protein-L-arginine ADP-D-ribosyltransferase activity" EXACT [EC:2.4.2.31]
synonym: "NAD(P)-arginine ADP-ribosyltransferase activity" EXACT []
synonym: "NAD+:L-arginine ADP-D-ribosyltransferase activity" EXACT [EC:2.4.2.31]
synonym: "peptidyl-arginine ADP-ribosylation activity" EXACT []
synonym: "protein-arginine ADP-ribosyltransferase activity" EXACT []
xref: EC:2.4.2.31
xref: MetaCyc:2.4.2.31-RXN
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0003957
name: NAD(P)+ transhydrogenase (B-specific) activity
namespace: molecular_function
def: "Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+, driving the transfer of a solute or solutes from one side of a membrane to the other. In the course of the reaction (left to right) one H atom is transferred from inside the cell to outside. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to both NAD+ and NADP+." [EC:1.6.1.1, http://pubs.acs.org/cgi-bin/abstract.cgi/jacsat/1991/113/i07/f-pdf/f_ja00007a002.pdf, MetaCyc:PYRNUTRANSHYDROGEN-RXN]
subset: gosubset_prok
synonym: "H+-thase" BROAD [EC:1.6.1.1]
synonym: "NAD transhydrogenase" BROAD [EC:1.6.1.1]
synonym: "NAD(P) transhydrogenase (B-specific) activity" EXACT []
synonym: "NADH transhydrogenase" BROAD [EC:1.6.1.1]
synonym: "NADH-NADP-transhydrogenase" BROAD [EC:1.6.1.1]
synonym: "NADPH-NAD oxidoreductase" BROAD [EC:1.6.1.1]
synonym: "NADPH-NAD transhydrogenase" BROAD [EC:1.6.1.1]
synonym: "NADPH:NAD+ oxidoreductase (B-specific)" EXACT [EC:1.6.1.1]
synonym: "NADPH:NAD+ transhydrogenase" BROAD [EC:1.6.1.1]
synonym: "nicotinamide adenine dinucleotide (phosphate) transhydrogenase" BROAD [EC:1.6.1.1]
synonym: "nicotinamide nucleotide transhydrogenase activity" BROAD [EC:1.6.1.1]
synonym: "non-energy-linked transhydrogenase activity" EXACT [EC:1.6.1.1]
synonym: "pyridine nucleotide transferase" BROAD [EC:1.6.1.1]
synonym: "pyridine nucleotide transhydrogenase activity" BROAD [EC:1.6.1.1]
xref: EC:1.6.1.1
xref: MetaCyc:PYRNUTRANSHYDROGEN-RXN
is_a: GO:0008746 ! NAD(P)+ transhydrogenase activity
is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity

[Term]
id: GO:0003958
name: NADPH-hemoprotein reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein." [EC:1.6.2.4]
subset: gosubset_prok
synonym: "aldehyde reductase (NADPH-dependent) activity" RELATED [EC:1.6.2.4]
synonym: "CPR activity" RELATED [EC:1.6.2.4]
synonym: "cytochrome c reductase (reduced nicotinamide adenine dinucleotide phosphate, NADPH, NADPH-dependent) activity" NARROW [EC:1.6.2.4]
synonym: "cytochrome P-450 reductase activity" EXACT [EC:1.6.2.4]
synonym: "cytochrome P450 reductase activity" NARROW [EC:1.6.2.4]
synonym: "dihydroxynicotinamide adenine dinucleotide phosphate-cytochrome c reductase activity" NARROW [EC:1.6.2.4]
synonym: "FAD-cytochrome c reductase activity" RELATED [EC:1.6.2.4]
synonym: "ferrihemoprotein P-450 reductase activity" RELATED [EC:1.6.2.4]
synonym: "NADP--cytochrome c reductase activity" NARROW [EC:1.6.2.4]
synonym: "NADP--cytochrome reductase activity" NARROW [EC:1.6.2.4]
synonym: "NADPH--cytochrome c oxidoreductase activity" NARROW [EC:1.6.2.4]
synonym: "NADPH--cytochrome c reductase activity" NARROW [EC:1.6.2.4]
synonym: "NADPH--cytochrome P450 oxidoreductase activity" NARROW [EC:1.6.2.4]
synonym: "NADPH--cytochrome P450 reductase activity" NARROW [EC:1.6.2.4]
synonym: "NADPH--ferricytochrome c oxidoreductase activity" NARROW [EC:1.6.2.4]
synonym: "NADPH--ferrihemoprotein reductase activity" NARROW [EC:1.6.2.4]
synonym: "NADPH-cytochrome P-450 oxidoreductase activity" EXACT [EC:1.6.2.4]
synonym: "NADPH-cytochrome p-450 reductase activity" EXACT [EC:1.6.2.4]
synonym: "NADPH-dependent cytochrome c reductase activity" NARROW [EC:1.6.2.4]
synonym: "NADPH-ferrihemoprotein reductase activity" EXACT []
synonym: "NADPH:cytochrome c reductase activity" EXACT []
synonym: "NADPH:cytochrome P450 reductase activity" EXACT []
synonym: "NADPH:ferrihemoprotein oxidoreductase activity" EXACT [EC:1.6.2.4]
synonym: "NADPH:hemoprotein oxidoreductase activity" EXACT [EC:1.6.2.4]
synonym: "NADPH:P-450 reductase activity" EXACT [EC:1.6.2.4]
synonym: "NADPH:P450 reductase activity" NARROW [EC:1.6.2.4]
synonym: "POR" RELATED [EC:1.6.2.4]
synonym: "reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase activity" NARROW [EC:1.6.2.4]
synonym: "reductase, cytochrome c (reduced nicotinamide adenine dinucleotide phosphate) activity" NARROW [EC:1.6.2.4]
synonym: "TPNH(2) cytochrome c reductase activity" NARROW [EC:1.6.2.4]
synonym: "TPNH-cytochrome c reductase activity" NARROW [EC:1.6.2.4]
synonym: "TPNH2 cytochrome c reductase activity" EXACT [EC:1.6.2.4]
xref: EC:1.6.2.4
xref: MetaCyc:NADPH--FERRIHEMOPROTEIN-REDUCTASE-RXN
is_a: GO:0016653 ! oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor

[Term]
id: GO:0003959
name: NADPH dehydrogenase activity
namespace: molecular_function
alt_id: GO:0008468
alt_id: GO:0016660
def: "Catalysis of the reaction: NADPH + H+ + quinone acceptor = NADP+ + hydroquinone." [EC:1.6.99.1]
subset: gosubset_prok
synonym: "dihydronicotinamide adenine dinucleotide phosphate dehydrogenase activity" EXACT [EC:1.6.99.1]
synonym: "NADPH diaphorase activity" EXACT [EC:1.6.99.1]
synonym: "NADPH-dehydrogenase activity" EXACT [EC:1.6.99.1]
synonym: "NADPH2 diaphorase activity" EXACT [EC:1.6.99.1]
synonym: "NADPH2-dehydrogenase activity" EXACT [EC:1.6.99.1]
synonym: "NADPH:(acceptor) oxidoreductase activity" EXACT [EC:1.6.99.1]
synonym: "NADPH:acceptor oxidoreductase activity" EXACT [EC:1.6.99.1]
synonym: "old yellow enzyme" RELATED [EC:1.6.99.1]
synonym: "OYE" RELATED [EC:1.6.99.1]
synonym: "reduced nicotinamide adenine dinucleotide phosphate dehydrogenase activity" EXACT [EC:1.6.99.1]
synonym: "TPNH dehydrogenase activity" EXACT [EC:1.6.99.1]
synonym: "TPNH-diaphorase activity" EXACT [EC:1.6.99.1]
synonym: "triphosphopyridine diaphorase activity" EXACT [EC:1.6.99.1]
synonym: "triphosphopyridine nucleotide diaphorase activity" EXACT [EC:1.6.99.1]
xref: EC:1.6.99.1
xref: MetaCyc:NADPH-DEHYDROGENASE-RXN
xref: UM-BBD_enzymeID:e0523
is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H

[Term]
id: GO:0003960
name: NADPH:quinone reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADPH + H+ + quinone = NADP+ + semiquinone." [EC:1.6.5.5]
subset: gosubset_prok
synonym: "NADPH:quinone oxidoreductase activity" EXACT [EC:1.6.5.5]
synonym: "quinone oxidoreductase activity" BROAD [EC:1.6.5.5]
synonym: "zeta-crystallin activity" NARROW [EC:1.6.5.5]
xref: EC:1.6.5.5
xref: MetaCyc:QOR-RXN
is_a: GO:0016655 ! oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor

[Term]
id: GO:0003961
name: O-acetylhomoserine aminocarboxypropyltransferase activity
namespace: molecular_function
alt_id: GO:0019282
def: "Catalysis of the reaction: O-acetyl-L-homoserine + methanethiol = L-methionine + acetate. Also reacts with other thiols and H2S, producing homocysteine or thioethers." [EC:2.5.1.49]
comment: Note that this function was formerly EC:4.2.99.10.
subset: gosubset_prok
synonym: "4.2.99.9" RELATED []
synonym: "L-methionine anabolism, direct, from O-acetyl-L-homoserine" EXACT [GOC:mah]
synonym: "L-methionine biosynthetic process, direct, from O-acetyl-L-homoserine" EXACT []
synonym: "L-methionine formation, direct, from O-acetyl-L-homoserine" EXACT [GOC:mah]
synonym: "L-methionine synthesis, direct, from O-acetyl-L-homoserine" EXACT [GOC:mah]
synonym: "methionine biosynthetic process, direct, from O-acetyl-L-homoserine" EXACT [GOC:mah]
synonym: "O-acetyl-L-homoserine acetate-lyase (adding methanethiol) activity" EXACT [EC:2.5.1.49]
synonym: "O-acetyl-L-homoserine sulfhydrolase activity" EXACT [EC:2.5.1.49]
synonym: "O-acetyl-L-homoserine:methanethiol 3-amino-3-carboxypropyltransferase activity" EXACT [EC:2.5.1.49]
synonym: "O-acetylhomoserine (thiol)-lyase activity" EXACT []
synonym: "O-acetylhomoserine sulfhydrolase activity" EXACT [EC:2.5.1.49]
synonym: "OAH sulfhydrylase activity" EXACT [EC:2.5.1.49]
xref: EC:2.5.1.49
xref: MetaCyc:O-ACETYLHOMOSERINE-THIOL-LYASE-RXN
xref: RHEA:10051
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups
relationship: part_of GO:0071266 ! 'de novo' L-methionine biosynthetic process

[Term]
id: GO:0003962
name: cystathionine gamma-synthase activity
namespace: molecular_function
alt_id: GO:0000505
def: "Catalysis of the reaction: O-succinyl-L-homoserine + L-cysteine = cystathionine + succinate." [EC:2.5.1.48]
comment: Formerly EC 4.2.99.9.
subset: gosubset_prok
synonym: "CTT gamma synthase activity" EXACT []
synonym: "cystathionine g-synthase activity" EXACT []
synonym: "cystathionine gamma synthase activity" EXACT []
synonym: "cystathionine synthase activity" EXACT [EC:2.5.1.48]
synonym: "cystathionine synthetase activity" EXACT [EC:2.5.1.48]
synonym: "homoserine O-transsuccinylase activity" BROAD [EC:2.5.1.48]
synonym: "homoserine transsuccinylase activity" BROAD [EC:2.5.1.48]
synonym: "O-succinyl-L-homoserine (thiol)-lyase activity" EXACT []
synonym: "O-succinyl-L-homoserine succinate-lyase (adding cysteine) activity" EXACT [EC:2.5.1.48]
synonym: "O-succinyl-L-homoserine succinate-lyase activity" EXACT []
synonym: "O-succinylhomoserine (thiol)-lyase activity" EXACT [EC:2.5.1.48]
synonym: "O-succinylhomoserine synthase activity" EXACT [EC:2.5.1.48]
synonym: "O-succinylhomoserine synthetase activity" EXACT [EC:2.5.1.48]
synonym: "O4-succinyl-L-homoserine:L-cysteine S-(3-amino-3-carboxypropyl)transferase activity" EXACT [EC:2.5.1.48]
xref: EC:2.5.1.48
xref: MetaCyc:O-SUCCHOMOSERLYASE-RXN
xref: RHEA:20400
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0003963
name: RNA-3'-phosphate cyclase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate." [EC:6.5.1.4]
subset: gosubset_prok
synonym: "RNA 3'-terminal phosphate cyclase activity" EXACT [EC:6.5.1.4]
synonym: "RNA cyclase activity" EXACT [EC:6.5.1.4]
synonym: "RNA-3'-phosphate:RNA ligase (cyclizing, AMP-forming)" EXACT [EC:6.5.1.4]
xref: EC:6.5.1.4
xref: MetaCyc:RNA-3-PHOSPHATE-CYCLASE-RXN
is_a: GO:0009975 ! cyclase activity
is_a: GO:0016886 ! ligase activity, forming phosphoric ester bonds

[Term]
id: GO:0003964
name: RNA-directed DNA polymerase activity
namespace: molecular_function
def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
subset: gosubset_prok
synonym: "deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed) activity" EXACT [EC:2.7.7.49]
synonym: "DNA nucleotidyltransferase (RNA-directed) activity" EXACT [EC:2.7.7.49]
synonym: "reverse transcriptase activity" EXACT [EC:2.7.7.49]
synonym: "revertase activity" RELATED [EC:2.7.7.49]
synonym: "RNA revertase activity" EXACT [EC:2.7.7.49]
synonym: "RNA-dependent deoxyribonucleate nucleotidyltransferase activity" EXACT [EC:2.7.7.49]
synonym: "RNA-dependent DNA polymerase activity" EXACT [EC:2.7.7.49]
synonym: "RNA-directed DNA polymerase, group II intron encoded" NARROW []
synonym: "RNA-directed DNA polymerase, transposon encoded" NARROW []
synonym: "RNA-instructed DNA polymerase activity" EXACT [EC:2.7.7.49]
synonym: "RT" RELATED [EC:2.7.7.49]
xref: EC:2.7.7.49
xref: MetaCyc:RNA-DIRECTED-DNA-POLYMERASE-RXN
xref: Reactome:REACT_9039 "Synthesis of minus strand strong stop DNA (-sssDNA), Homo sapiens"
xref: Reactome:REACT_9049 "Minus strand DNA synthesis resumes, Homo sapiens"
is_a: GO:0034061 ! DNA polymerase activity
relationship: part_of GO:0006278 ! RNA-dependent DNA biosynthetic process

[Term]
id: GO:0003966
name: obsolete RNA-directed DNA polymerase, transposon encoded
namespace: molecular_function
def: "OBSOLETE. Catalysis of RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time; cannot initiate a chain de novo." [EC:2.7.7.49]
comment: This term was made obsolete because it does not represent a function distinct from its parent term 'RNA-directed DNA polymerase'.
synonym: "RNA-directed DNA polymerase, transposon encoded" EXACT []
is_obsolete: true
replaced_by: GO:0003964

[Term]
id: GO:0003967
name: obsolete RNA-directed DNA polymerase, group II intron encoded
namespace: molecular_function
def: "OBSOLETE. Catalysis of RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time; cannot initiate a chain de novo." [EC:2.7.7.49]
comment: This term was made obsolete because it does not represent a function distinct from its parent term 'RNA-directed DNA polymerase'.
synonym: "RNA-directed DNA polymerase, group II intron encoded" EXACT []
is_obsolete: true
replaced_by: GO:0003964

[Term]
id: GO:0003968
name: RNA-directed RNA polymerase activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template." [EC:2.7.7.48, GOC:mah]
subset: gosubset_prok
synonym: "3D polymerase activity" EXACT [EC:2.7.7.48]
synonym: "nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)" EXACT [EC:2.7.7.48]
synonym: "PB1 proteins" RELATED [EC:2.7.7.48]
synonym: "PB2 proteins" RELATED [EC:2.7.7.48]
synonym: "phage f2 replicase" NARROW [EC:2.7.7.48]
synonym: "polymerase L" RELATED [EC:2.7.7.48]
synonym: "Q-beta replicase activity" EXACT [EC:2.7.7.48]
synonym: "RDRP" RELATED [EC:2.7.7.48]
synonym: "ribonucleic acid replicase activity" EXACT [EC:2.7.7.48]
synonym: "ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity" EXACT [EC:2.7.7.48]
synonym: "ribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [EC:2.7.7.48]
synonym: "ribonucleic replicase activity" EXACT [EC:2.7.7.48]
synonym: "ribonucleic synthetase activity" RELATED [EC:2.7.7.48]
synonym: "RNA nucleotidyltransferase (RNA-directed) activity" EXACT [EC:2.7.7.48]
synonym: "RNA replicase activity" EXACT [EC:2.7.7.48]
synonym: "RNA synthetase activity" RELATED [EC:2.7.7.48]
synonym: "RNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [EC:2.7.7.48]
synonym: "RNA-dependent RNA polymerase activity" EXACT [EC:2.7.7.48]
synonym: "RNA-dependent RNA replicase activity" EXACT [EC:2.7.7.48]
synonym: "transcriptase" BROAD [EC:2.7.7.48]
xref: EC:2.7.7.48
xref: MetaCyc:RNA-DIRECTED-RNA-POLYMERASE-RXN
xref: Reactome:REACT_6210 "Elongation of viral mRNA, Homo sapiens"
xref: Reactome:REACT_6239 "Priming and Initiation of Transcription, Homo sapiens"
xref: Reactome:REACT_6264 "Polyadenylation and Termination, Homo sapiens"
xref: Reactome:REACT_9404 "cRNA Extension, Homo sapiens"
xref: Reactome:REACT_9438 "vRNA Extension, Homo sapiens"
xref: Reactome:REACT_9487 "Initiation of vRNA Synthesis, Homo sapiens"
xref: Reactome:REACT_9513 "Initiation of cRNA Synthesis, Homo sapiens"
is_a: GO:0034062 ! RNA polymerase activity
relationship: part_of GO:0001172 ! transcription, RNA-templated

[Term]
id: GO:0003969
name: obsolete RNA editase activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it describes a biological process.
synonym: "RNA editase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0003972
name: RNA ligase (ATP) activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + ribonucleotide(n) + ribonucleotide(m) = AMP + diphosphate + ribonucleotide(n+m)." [EC:6.5.1.3]
subset: gosubset_prok
synonym: "poly(ribonucleotide):poly(ribonucleotide) ligase (AMP-forming)" EXACT [EC:6.5.1.3]
synonym: "polyribonucleotide ligase activity" EXACT [EC:6.5.1.3]
synonym: "polyribonucleotide synthase (ATP) activity" EXACT [EC:6.5.1.3]
synonym: "ribonucleic ligase activity" BROAD [EC:6.5.1.3]
xref: EC:6.5.1.3
xref: MetaCyc:RNA-LIGASE-ATP-RXN
is_a: GO:0008452 ! RNA ligase activity

[Term]
id: GO:0003973
name: (S)-2-hydroxy-acid oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-2-hydroxy-acid + O2 = 2-oxo acid + hydrogen peroxide." [EC:1.1.3.15]
subset: gosubset_prok
synonym: "(S)-2-hydroxy-acid:oxygen 2-oxidoreductase" EXACT [EC:1.1.3.15]
synonym: "hydroxy-acid oxidase A activity" NARROW [EC:1.1.3.15]
synonym: "hydroxy-acid oxidase B activity" NARROW [EC:1.1.3.15]
synonym: "hydroxyacid oxidase A" RELATED [EC:1.1.3.15]
synonym: "L-2-hydroxy acid oxidase" EXACT [EC:1.1.3.15]
synonym: "L-alpha-hydroxy acid oxidase" EXACT [EC:1.1.3.15]
synonym: "oxidase, L-2-hydroxy acid" EXACT [EC:1.1.3.15]
xref: EC:1.1.3.15
xref: MetaCyc:S-2-HYDROXY-ACID-OXIDASE-RXN
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0003974
name: UDP-N-acetylglucosamine 4-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-galactosamine." [EC:5.1.3.7]
subset: gosubset_prok
synonym: "UDP acetylglucosamine epimerase activity" EXACT [EC:5.1.3.7]
synonym: "UDP-GlcNAc 4-epimerase activity" EXACT [EC:5.1.3.7]
synonym: "UDP-N-acetyl-D-glucosamine 4-epimerase activity" EXACT [EC:5.1.3.7]
synonym: "uridine 5'-diphospho-N-acetylglucosamine-4-epimerase activity" EXACT [EC:5.1.3.7]
synonym: "uridine diphosphate N-acetylglucosamine-4-epimerase activity" EXACT [EC:5.1.3.7]
synonym: "uridine diphosphoacetylglucosamine epimerase activity" EXACT [EC:5.1.3.7]
xref: EC:5.1.3.7
xref: MetaCyc:UDP-N-ACETYLGLUCOSAMINE-4-EPIMERASE-RXN
xref: RHEA:20520
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0003975
name: UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol." [EC:2.7.8.15]
subset: gosubset_prok
synonym: "chitobiosylpyrophosphoryldolichol synthase activity" EXACT [EC:2.7.8.15]
synonym: "dolichol phosphate N-acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.15]
synonym: "GlcNAc-1-P transferase activity" EXACT [EC:2.7.8.15]
synonym: "N-acetylglucosamine-1-phosphate transferase activity" EXACT [EC:2.7.8.15]
synonym: "UDP-acetylglucosamine-dolichol phosphate acetylglucosamine phosphotransferase activity" EXACT [EC:2.7.8.15]
synonym: "UDP-acetylglucosamine-dolichol phosphate acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.15]
synonym: "UDP-D-N-acetylglucosamine N-acetylglucosamine 1-phosphate transferase activity" EXACT [EC:2.7.8.15]
synonym: "UDP-GlcNAc:dolichyl-phosphate GlcNAc-1-phosphate transferase activity" EXACT [EC:2.7.8.15]
synonym: "UDP-N-acetyl-D-glucosamine:dolichol phosphate N-acetyl-D-glucosamine-1-phosphate transferase activity" EXACT [EC:2.7.8.15]
synonym: "UDP-N-acetyl-D-glucosamine:dolichyl-phosphate N-acetyl-D-glucosaminephosphotransferase activity" EXACT [EC:2.7.8.15]
synonym: "UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosamine-1-phosphate transferase activity" EXACT []
synonym: "uridine diphosphoacetylglucosamine-dolichyl phosphate acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.15]
xref: EC:2.7.8.15
xref: MetaCyc:2.7.8.15-RXN
xref: Reactome:REACT_22147 "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate, Homo sapiens"
xref: RHEA:13292
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0003976
name: UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose = UMP + lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose." [EC:2.7.8.17]
synonym: "lysosomal enzyme precursor acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.17]
synonym: "N-acetylglucosaminyl phosphotransferase activity" EXACT [EC:2.7.8.17]
synonym: "N-acetylglucosaminylphosphotransferase activity" RELATED [EC:2.7.8.17]
synonym: "UDP-GlcNAc:glycoprotein N-acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.17]
synonym: "UDP-N-acetyl-D-glucosamine:lysosomal-enzyme N-acetylglucosaminephosphotransferase activity" EXACT [EC:2.7.8.17]
synonym: "UDP-N-acetylglucosamine:glycoprotein N-acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.17]
synonym: "UDP-N-acetylglucosamine:glycoprotein N-acetylglucosaminyl-1-phosphotransferase activity" EXACT [EC:2.7.8.17]
synonym: "UDP-N-acetylglucosamine:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.17]
xref: EC:2.7.8.17
xref: MetaCyc:2.7.8.17-RXN
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0003977
name: UDP-N-acetylglucosamine diphosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine." [EC:2.7.7.23, RHEA:13512]
subset: gosubset_prok
synonym: "acetylglucosamine 1-phosphate uridylyltransferase" BROAD [EC:2.7.7.23]
synonym: "GlmU uridylyltransferase activity" EXACT [EC:2.7.7.23]
synonym: "N-acetylglucosamine-1-phosphate uridyltransferase activity" EXACT [EC:2.7.7.23]
synonym: "UDP-acetylglucosamine pyrophosphorylase activity" EXACT [EC:2.7.7.23]
synonym: "UDP-GlcNAc pyrophosphorylase activity" EXACT [EC:2.7.7.23]
synonym: "UDP-N-acetylglucosamine pyrophosphorylase activity" EXACT []
synonym: "uridine diphosphate-N-acetylglucosamine pyrophosphorylase activity" EXACT [EC:2.7.7.23]
synonym: "uridine diphosphoacetylglucosamine phosphorylase activity" EXACT [EC:2.7.7.23]
synonym: "uridine diphosphoacetylglucosamine pyrophosphorylase activity" EXACT [EC:2.7.7.23]
synonym: "UTP:2-acetamido-2-deoxy-alpha-D-glucose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.23]
synonym: "UTP:N-acetyl-alpha-D-glucosamine-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.23]
xref: EC:2.7.7.23
xref: KEGG:R00416
xref: MetaCyc:NAG1P-URIDYLTRANS-RXN
xref: Reactome:REACT_22397 "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine, Homo sapiens"
xref: RHEA:13512
is_a: GO:0070569 ! uridylyltransferase activity

[Term]
id: GO:0003978
name: UDP-glucose 4-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose = UDP-galactose." [EC:5.1.3.2]
subset: gosubset_prok
synonym: "4-epimerase activity" EXACT [EC:5.1.3.2]
synonym: "galactowaldenase activity" RELATED [EC:5.1.3.2]
synonym: "UDP-D-galactose 4-epimerase activity" EXACT [EC:5.1.3.2]
synonym: "UDP-galactose 4-epimerase activity" EXACT [EC:5.1.3.2]
synonym: "UDP-glucose epimerase activity" EXACT [EC:5.1.3.2]
synonym: "UDPG-4-epimerase activity" EXACT [EC:5.1.3.2]
synonym: "UDPgalactose 4-epimerase activity" EXACT [EC:5.1.3.2]
synonym: "UDPglucose 4-epimerase activity" EXACT [EC:5.1.3.2]
synonym: "uridine diphosphate galactose 4-epimerase activity" EXACT [EC:5.1.3.2]
synonym: "uridine diphosphate glucose 4-epimerase activity" EXACT [EC:5.1.3.2]
synonym: "uridine diphospho-galactose-4-epimerase activity" EXACT [EC:5.1.3.2]
synonym: "uridine diphosphoglucose 4-epimerase activity" EXACT [EC:5.1.3.2]
synonym: "uridine diphosphoglucose epimerase activity" EXACT [EC:5.1.3.2]
xref: EC:5.1.3.2
xref: MetaCyc:UDPGLUCEPIM-RXN
xref: Reactome:REACT_102168 "UDP-galactose <=> UDP-glucose, Rattus norvegicus"
xref: Reactome:REACT_115000 "UDP-galactose <=> UDP-glucose, Arabidopsis thaliana"
xref: Reactome:REACT_115332 "UDP-galactose <=> UDP-glucose, Schizosaccharomyces pombe"
xref: Reactome:REACT_115411 "UDP-galactose <=> UDP-glucose, Oryza sativa"
xref: Reactome:REACT_1315 "UDP-galactose <=> UDP-glucose, Homo sapiens"
xref: Reactome:REACT_31550 "UDP-galactose <=> UDP-glucose, Bos taurus"
xref: Reactome:REACT_33528 "UDP-galactose <=> UDP-glucose, Gallus gallus"
xref: Reactome:REACT_34575 "UDP-galactose <=> UDP-glucose, Xenopus tropicalis"
xref: Reactome:REACT_78749 "UDP-galactose <=> UDP-glucose, Staphylococcus aureus N315"
xref: Reactome:REACT_78984 "UDP-galactose <=> UDP-glucose, Canis familiaris"
xref: Reactome:REACT_83662 "UDP-galactose <=> UDP-glucose, Taeniopygia guttata"
xref: Reactome:REACT_84187 "UDP-galactose <=> UDP-glucose, Drosophila melanogaster"
xref: Reactome:REACT_87173 "UDP-galactose <=> UDP-glucose, Mus musculus"
xref: Reactome:REACT_87677 "UDP-galactose <=> UDP-glucose, Caenorhabditis elegans"
xref: Reactome:REACT_90321 "UDP-galactose <=> UDP-glucose, Escherichia coli"
xref: Reactome:REACT_91321 "UDP-galactose <=> UDP-glucose, Danio rerio"
xref: Reactome:REACT_94034 "UDP-galactose <=> UDP-glucose, Dictyostelium discoideum"
xref: Reactome:REACT_97325 "UDP-galactose <=> UDP-glucose, Saccharomyces cerevisiae"
xref: RHEA:22171
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0003979
name: UDP-glucose 6-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate." [EC:1.1.1.22, RHEA:23599]
subset: gosubset_prok
xref: EC:1.1.1.22
xref: KEGG:R00286
xref: MetaCyc:UGD-RXN
xref: Reactome:REACT_101674 "UDP-glucose is oxidised to UDP-glucuronate, Gallus gallus"
xref: Reactome:REACT_102401 "UDP-glucose is oxidised to UDP-glucuronate, Drosophila melanogaster"
xref: Reactome:REACT_103324 "UDP-glucose is oxidised to UDP-glucuronate, Oryza sativa"
xref: Reactome:REACT_104028 "UDP-glucose is oxidised to UDP-glucuronate, Mus musculus"
xref: Reactome:REACT_106090 "UDP-glucose is oxidised to UDP-glucuronate, Taeniopygia guttata"
xref: Reactome:REACT_112524 "UDP-glucose is oxidised to UDP-glucuronate, Escherichia coli"
xref: Reactome:REACT_28362 "UDP-glucose is oxidised to UDP-glucuronate, Caenorhabditis elegans"
xref: Reactome:REACT_30359 "UDP-glucose is oxidised to UDP-glucuronate, Arabidopsis thaliana"
xref: Reactome:REACT_32524 "UDP-glucose is oxidised to UDP-glucuronate, Rattus norvegicus"
xref: Reactome:REACT_6876 "UDP-glucose is oxidised to UDP-glucuronate, Homo sapiens"
xref: Reactome:REACT_82981 "UDP-glucose is oxidised to UDP-glucuronate, Mycobacterium tuberculosis"
xref: Reactome:REACT_90704 "UDP-glucose is oxidised to UDP-glucuronate, Danio rerio"
xref: Reactome:REACT_90852 "UDP-glucose is oxidised to UDP-glucuronate, Canis familiaris"
xref: Reactome:REACT_93404 "UDP-glucose is oxidised to UDP-glucuronate, Bos taurus"
xref: Reactome:REACT_98306 "UDP-glucose is oxidised to UDP-glucuronate, Staphylococcus aureus N315"
xref: Reactome:REACT_98484 "UDP-glucose is oxidised to UDP-glucuronate, Xenopus tropicalis"
xref: RHEA:23599
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0003980
name: UDP-glucose:glycoprotein glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the addition of UDP-glucose on to asparagine-linked (N-linked) oligosaccharides of the form Man7-9GlcNAc2 on incorrectly folded glycoproteins." [GOC:al, PMID:10764828]
synonym: "UGGT activity" EXACT []
xref: EC:2.4.1.-
xref: Reactome:REACT_25264 "Re-addition of a glucose on the alpha 1,3 branch, Homo sapiens"
is_a: GO:0035251 ! UDP-glucosyltransferase activity
relationship: part_of GO:0097359 ! UDP-glucosylation

[Term]
id: GO:0003983
name: UTP:glucose-1-phosphate uridylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate + UTP = diphosphate + UDP-D-glucose." [EC:2.7.7.9, RHEA:19892]
subset: gosubset_prok
synonym: "glucose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.9]
synonym: "UDP glucose pyrophosphorylase activity" EXACT [EC:2.7.7.9]
synonym: "UDP-glucose diphosphorylase activity" EXACT [EC:2.7.7.9]
synonym: "UDP-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.9]
synonym: "UDPG phosphorylase activity" EXACT [EC:2.7.7.9]
synonym: "UDPG pyrophosphorylase activity" EXACT [EC:2.7.7.9]
synonym: "uridine 5'-diphosphoglucose pyrophosphorylase activity" EXACT [EC:2.7.7.9]
synonym: "uridine diphosphate-D-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.9]
synonym: "uridine diphosphoglucose pyrophosphorylase activity" EXACT [EC:2.7.7.9]
synonym: "uridine-diphosphate glucose pyrophosphorylase activity" EXACT [EC:2.7.7.9]
synonym: "UTP-glucose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.9]
synonym: "UTP:alpha-D-glucose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.9]
xref: EC:2.7.7.9
xref: KEGG:R00289
xref: MetaCyc:GLUC1PURIDYLTRANS-RXN
xref: Reactome:REACT_101085 "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose, Saccharomyces cerevisiae"
xref: Reactome:REACT_101096 "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose, Sus scrofa"
xref: Reactome:REACT_103410 "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose, Schizosaccharomyces pombe"
xref: Reactome:REACT_103497 "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose, Taeniopygia guttata"
xref: Reactome:REACT_104734 "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose, Oryza sativa"
xref: Reactome:REACT_105080 "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose, Caenorhabditis elegans"
xref: Reactome:REACT_110476 "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose, Danio rerio"
xref: Reactome:REACT_82849 "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose, Xenopus tropicalis"
xref: Reactome:REACT_84996 "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose, Arabidopsis thaliana"
xref: Reactome:REACT_85597 "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose, Canis familiaris"
xref: Reactome:REACT_86 "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose, Homo sapiens"
xref: Reactome:REACT_87986 "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose, Mus musculus"
xref: Reactome:REACT_90031 "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose, Drosophila melanogaster"
xref: Reactome:REACT_91019 "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose, Gallus gallus"
xref: Reactome:REACT_94840 "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose, Dictyostelium discoideum"
xref: Reactome:REACT_95999 "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose, Bos taurus"
xref: Reactome:REACT_98501 "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose, Rattus norvegicus"
xref: RHEA:19892
is_a: GO:0051748 ! UTP-monosaccharide-1-phosphate uridylyltransferase activity

[Term]
id: GO:0003984
name: acetolactate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 pyruvate = 2-acetolactate + CO2." [EC:2.2.1.6]
comment: Note that this function was formerly EC:4.1.3.18.
subset: gosubset_prok
synonym: "acetohydroxy acid synthetase activity" EXACT [EC:2.2.1.6]
synonym: "acetohydroxyacid synthase activity" EXACT [EC:2.2.1.6]
synonym: "acetolactate pyruvate-lyase (carboxylating) activity" EXACT [EC:2.2.1.6]
synonym: "acetolactic synthetase activity" EXACT [EC:2.2.1.6]
synonym: "alpha-acetohydroxy acid synthetase activity" EXACT [EC:2.2.1.6]
synonym: "alpha-acetohydroxyacid synthase activity" EXACT [EC:2.2.1.6]
synonym: "alpha-acetolactate synthase activity" EXACT [EC:2.2.1.6]
synonym: "alpha-acetolactate synthetase activity" EXACT [EC:2.2.1.6]
synonym: "pyruvate:pyruvate acetaldehydetransferase (decarboxylating)" EXACT [EC:2.2.1.6]
xref: EC:2.2.1.6
xref: MetaCyc:ACETOLACTSYN-RXN
xref: RHEA:20504
is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups

[Term]
id: GO:0003985
name: acetyl-CoA C-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA." [EC:2.3.1.9]
subset: gosubset_prok
synonym: "2-methylacetoacetyl-CoA thiolase" BROAD [EC:2.3.1.9]
synonym: "3-oxothiolase activity" EXACT [EC:2.3.1.9]
synonym: "acetoacetyl-CoA thiolase activity" EXACT [EC:2.3.1.9]
synonym: "acetyl coenzyme A thiolase activity" EXACT [EC:2.3.1.9]
synonym: "acetyl-CoA acetyltransferase activity" EXACT [EC:2.3.1.9]
synonym: "acetyl-CoA:acetyl-CoA C-acetyltransferase activity" EXACT [EC:2.3.1.9]
synonym: "acetyl-CoA:N-acetyltransferase activity" EXACT [EC:2.3.1.9]
synonym: "beta-acetoacetyl coenzyme A thiolase activity" EXACT [EC:2.3.1.9]
synonym: "thiolase II" RELATED [EC:2.3.1.9]
xref: EC:2.3.1.9
xref: MetaCyc:ACETYL-COA-ACETYLTRANSFER-RXN
xref: Reactome:REACT_100461 "2 acetyl-CoA <=> acetoacetyl-CoA + CoA, Danio rerio"
xref: Reactome:REACT_102319 "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA, Mycobacterium tuberculosis"
xref: Reactome:REACT_102321 "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA, Danio rerio"
xref: Reactome:REACT_102563 "2 acetyl-CoA <=> acetoacetyl-CoA + CoA, Rattus norvegicus"
xref: Reactome:REACT_102876 "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA, Mycobacterium tuberculosis"
xref: Reactome:REACT_103568 "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA, Drosophila melanogaster"
xref: Reactome:REACT_103940 "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA, Canis familiaris"
xref: Reactome:REACT_104958 "2 acetyl-CoA <=> acetoacetyl-CoA + CoA, Mus musculus"
xref: Reactome:REACT_105003 "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA, Taeniopygia guttata"
xref: Reactome:REACT_105426 "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA, Bos taurus"
xref: Reactome:REACT_105877 "2 acetyl-CoA <=> acetoacetyl-CoA + CoA, Mycobacterium tuberculosis"
xref: Reactome:REACT_106542 "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA, Dictyostelium discoideum"
xref: Reactome:REACT_109820 "2 acetyl-CoA <=> acetoacetyl-CoA + CoA, Dictyostelium discoideum"
xref: Reactome:REACT_109899 "2 acetyl-CoA <=> acetoacetyl-CoA + CoA, Bos taurus"
xref: Reactome:REACT_112932 "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA, Caenorhabditis elegans"
xref: Reactome:REACT_113533 "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA, Caenorhabditis elegans"
xref: Reactome:REACT_114812 "2 acetyl-CoA <=> acetoacetyl-CoA + CoA, Caenorhabditis elegans"
xref: Reactome:REACT_1478 "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA, Homo sapiens"
xref: Reactome:REACT_28462 "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA, Plasmodium falciparum"
xref: Reactome:REACT_28526 "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA, Plasmodium falciparum"
xref: Reactome:REACT_28646 "2 acetyl-CoA <=> acetoacetyl-CoA + CoA, Canis familiaris"
xref: Reactome:REACT_31277 "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA, Mus musculus"
xref: Reactome:REACT_31739 "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA, Xenopus tropicalis"
xref: Reactome:REACT_31976 "2 acetyl-CoA <=> acetoacetyl-CoA + CoA, Xenopus tropicalis"
xref: Reactome:REACT_32156 "2 acetyl-CoA <=> acetoacetyl-CoA + CoA, Gallus gallus"
xref: Reactome:REACT_47 "2 acetyl-CoA <=> acetoacetyl-CoA + CoA, Homo sapiens"
xref: Reactome:REACT_79103 "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA, Schizosaccharomyces pombe"
xref: Reactome:REACT_79150 "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA, Rattus norvegicus"
xref: Reactome:REACT_80792 "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA, Saccharomyces cerevisiae"
xref: Reactome:REACT_81504 "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA, Taeniopygia guttata"
xref: Reactome:REACT_82257 "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA, Xenopus tropicalis"
xref: Reactome:REACT_83250 "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA, Gallus gallus"
xref: Reactome:REACT_83764 "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA, Drosophila melanogaster"
xref: Reactome:REACT_84180 "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA, Gallus gallus"
xref: Reactome:REACT_84285 "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA, Schizosaccharomyces pombe"
xref: Reactome:REACT_85056 "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA, Danio rerio"
xref: Reactome:REACT_85622 "2 acetyl-CoA <=> acetoacetyl-CoA + CoA, Taeniopygia guttata"
xref: Reactome:REACT_86508 "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA, Bos taurus"
xref: Reactome:REACT_88187 "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA, Rattus norvegicus"
xref: Reactome:REACT_884 "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA, Homo sapiens"
xref: Reactome:REACT_92663 "2 acetyl-CoA <=> acetoacetyl-CoA + CoA, Schizosaccharomyces pombe"
xref: Reactome:REACT_92854 "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA, Mus musculus"
xref: Reactome:REACT_93534 "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA, Dictyostelium discoideum"
xref: Reactome:REACT_93658 "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA, Canis familiaris"
xref: Reactome:REACT_93946 "2 acetyl-CoA <=> acetoacetyl-CoA + CoA, Drosophila melanogaster"
xref: Reactome:REACT_96819 "2 acetyl-CoA <=> acetoacetyl-CoA + CoA, Plasmodium falciparum"
xref: Reactome:REACT_97416 "2 acetyl-CoA <=> acetoacetyl-CoA + CoA, Saccharomyces cerevisiae"
xref: Reactome:REACT_97821 "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA, Saccharomyces cerevisiae"
xref: RHEA:21039
xref: UM-BBD_enzymeID:e0144
is_a: GO:0003988 ! acetyl-CoA C-acyltransferase activity
is_a: GO:0016453 ! C-acetyltransferase activity

[Term]
id: GO:0003986
name: acetyl-CoA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + H(2)O = acetate + CoA + H(+)." [EC:3.1.2.1, RHEA:20292]
subset: gosubset_prok
synonym: "acetyl coenzyme A acylase activity" EXACT [EC:3.1.2.1]
synonym: "acetyl coenzyme A deacylase activity" EXACT [EC:3.1.2.1]
synonym: "acetyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.1]
synonym: "acetyl-CoA acylase activity" EXACT [EC:3.1.2.1]
synonym: "acetyl-CoA deacylase activity" EXACT [EC:3.1.2.1]
synonym: "acetyl-CoA thiol esterase activity" EXACT [EC:3.1.2.1]
xref: EC:3.1.2.1
xref: KEGG:R00227
xref: MetaCyc:ACETYL-COA-HYDROLASE-RXN
xref: Reactome:REACT_102494 "acetyl-CoA + H2O => acetate + CoASH, Canis familiaris"
xref: Reactome:REACT_104855 "acetyl-CoA + H2O => acetate + CoASH, Oryza sativa"
xref: Reactome:REACT_105619 "acetyl-CoA + H2O => acetate + CoASH, Xenopus tropicalis"
xref: Reactome:REACT_105926 "acetyl-CoA + H2O => acetate + CoASH, Caenorhabditis elegans"
xref: Reactome:REACT_109012 "acetyl-CoA + H2O => acetate + CoASH, Arabidopsis thaliana"
xref: Reactome:REACT_109195 "acetyl-CoA + H2O => acetate + CoASH, Mus musculus"
xref: Reactome:REACT_16974 "acetyl-CoA + H2O => acetate + CoASH, Homo sapiens"
xref: Reactome:REACT_77871 "acetyl-CoA + H2O => acetate + CoASH, Escherichia coli"
xref: Reactome:REACT_83459 "acetyl-CoA + H2O => acetate + CoASH, Mycobacterium tuberculosis"
xref: Reactome:REACT_86591 "acetyl-CoA + H2O => acetate + CoASH, Gallus gallus"
xref: Reactome:REACT_88142 "acetyl-CoA + H2O => acetate + CoASH, Danio rerio"
xref: Reactome:REACT_89514 "acetyl-CoA + H2O => acetate + CoASH, Sus scrofa"
xref: Reactome:REACT_94225 "acetyl-CoA + H2O => acetate + CoASH, Rattus norvegicus"
xref: Reactome:REACT_94231 "acetyl-CoA + H2O => acetate + CoASH, Taeniopygia guttata"
xref: Reactome:REACT_98144 "acetyl-CoA + H2O => acetate + CoASH, Saccharomyces cerevisiae"
xref: Reactome:REACT_99433 "acetyl-CoA + H2O => acetate + CoASH, Bos taurus"
xref: RHEA:20292
is_a: GO:0016289 ! CoA hydrolase activity

[Term]
id: GO:0003987
name: acetate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA." [EC:6.2.1.1]
subset: gosubset_prok
synonym: "acetate thiokinase activity" BROAD [EC:6.2.1.1]
synonym: "acetate to acetyl-CoA" RELATED []
synonym: "acetate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.1]
synonym: "acetic thiokinase activity" EXACT [EC:6.2.1.1]
synonym: "acetyl activating enzyme" RELATED [EC:6.2.1.1]
synonym: "acetyl CoA ligase activity" EXACT [EC:6.2.1.1]
synonym: "acetyl CoA synthase activity" EXACT [EC:6.2.1.1]
synonym: "acetyl coenzyme A synthetase activity" EXACT [EC:6.2.1.1]
synonym: "acetyl-activating enzyme activity" EXACT [EC:6.2.1.1]
synonym: "acetyl-CoA synthase activity" EXACT [EC:6.2.1.1]
synonym: "acetyl-CoA synthetase activity" EXACT [EC:6.2.1.1]
synonym: "acetyl-coenzyme A synthase activity" EXACT [EC:6.2.1.1]
synonym: "ACS" RELATED [EC:6.2.1.1]
synonym: "acyl-activating enzyme activity" BROAD [EC:6.2.1.1]
synonym: "short chain fatty acyl-CoA synthetase activity" EXACT [EC:6.2.1.1]
synonym: "short-chain acyl-coenzyme A synthetase activity" EXACT [EC:6.2.1.1]
xref: EC:6.2.1.1
xref: MetaCyc:ACETATE--COA-LIGASE-RXN
xref: Reactome:REACT_101761 "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic], Canis familiaris"
xref: Reactome:REACT_102092 "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic], Rattus norvegicus"
xref: Reactome:REACT_103963 "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic], Arabidopsis thaliana"
xref: Reactome:REACT_106135 "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic], Mycobacterium tuberculosis"
xref: Reactome:REACT_107058 "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic], Xenopus tropicalis"
xref: Reactome:REACT_112167 "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic], Escherichia coli"
xref: Reactome:REACT_21284 "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial], Homo sapiens"
xref: Reactome:REACT_30831 "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic], Oryza sativa"
xref: Reactome:REACT_31444 "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic], Bos taurus"
xref: Reactome:REACT_32745 "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic], Danio rerio"
xref: Reactome:REACT_553 "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic], Homo sapiens"
xref: Reactome:REACT_80622 "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic], Drosophila melanogaster"
xref: Reactome:REACT_84415 "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic], Sus scrofa"
xref: Reactome:REACT_85826 "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic], Mus musculus"
xref: Reactome:REACT_92738 "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic], Taeniopygia guttata"
xref: Reactome:REACT_96131 "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic], Gallus gallus"
xref: Reactome:REACT_98155 "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic], Caenorhabditis elegans"
xref: RHEA:23179
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0003988
name: acetyl-CoA C-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA." [EC:2.3.1.16]
subset: gosubset_prok
synonym: "2-keto-acyl thiolase activity" EXACT []
synonym: "2-methylacetoacetyl-CoA thiolase" BROAD [EC:2.3.1.16]
synonym: "3-ketoacyl CoA thiolase activity" EXACT [EC:2.3.1.16]
synonym: "3-ketoacyl coenzyme A thiolase activity" EXACT [EC:2.3.1.16]
synonym: "3-ketoacyl thiolase activity" EXACT [EC:2.3.1.16]
synonym: "3-ketoacyl-CoA thiolase activity" EXACT []
synonym: "3-ketothiolase activity" EXACT [EC:2.3.1.16]
synonym: "3-oxoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16]
synonym: "3-oxoacyl-coenzyme A thiolase activity" EXACT [EC:2.3.1.16]
synonym: "6-oxoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16]
synonym: "acetoacetyl-CoA beta-ketothiolase activity" EXACT [EC:2.3.1.16]
synonym: "acetyl-CoA acyltransferase activity" EXACT [EC:2.3.1.16]
synonym: "acyl-CoA:acetyl-CoA C-acyltransferase activity" EXACT [EC:2.3.1.16]
synonym: "beta-ketoacyl coenzyme A thiolase activity" EXACT [EC:2.3.1.16]
synonym: "beta-ketoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16]
synonym: "beta-ketoadipyl coenzyme A thiolase activity" EXACT [EC:2.3.1.16]
synonym: "beta-ketoadipyl-CoA thiolase activity" EXACT [EC:2.3.1.16]
synonym: "beta-ketothiolase activity" EXACT [EC:2.3.1.16]
synonym: "KAT" RELATED [EC:2.3.1.16]
synonym: "ketoacyl-CoA acyltransferase activity" EXACT [EC:2.3.1.16]
synonym: "ketoacyl-coenzyme A thiolase activity" EXACT [EC:2.3.1.16]
synonym: "long-chain 3-oxoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16]
synonym: "oxoacyl-coenzyme A thiolase activity" EXACT [EC:2.3.1.16]
synonym: "pro-3-ketoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16]
synonym: "thiolase I" RELATED [EC:2.3.1.16]
xref: EC:2.3.1.16
xref: MetaCyc:KETOACYLCOATHIOL-RXN
xref: Reactome:REACT_106127 "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA, Arabidopsis thaliana"
xref: Reactome:REACT_106648 "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA, Xenopus tropicalis"
xref: Reactome:REACT_106889 "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA, Gallus gallus"
xref: Reactome:REACT_110593 "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA, Sus scrofa"
xref: Reactome:REACT_16946 "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA, Homo sapiens"
xref: Reactome:REACT_29227 "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA, Canis familiaris"
xref: Reactome:REACT_30577 "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA, Oryza sativa"
xref: Reactome:REACT_79644 "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA, Taeniopygia guttata"
xref: Reactome:REACT_83687 "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA, Dictyostelium discoideum"
xref: Reactome:REACT_85643 "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA, Bos taurus"
xref: Reactome:REACT_87029 "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA, Mus musculus"
xref: Reactome:REACT_88222 "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA, Rattus norvegicus"
xref: Reactome:REACT_93039 "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA, Danio rerio"
xref: Reactome:REACT_94311 "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA, Saccharomyces cerevisiae"
xref: Reactome:REACT_99914 "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA, Staphylococcus aureus N315"
xref: RHEA:21567
xref: UM-BBD_reactionID:r1051
is_a: GO:0016408 ! C-acyltransferase activity

[Term]
id: GO:0003989
name: acetyl-CoA carboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA." [EC:6.4.1.2]
subset: gosubset_prok
synonym: "acetyl coenzyme A carboxylase activity" EXACT [EC:6.4.1.2]
synonym: "acetyl-CoA:carbon-dioxide ligase (ADP-forming)" EXACT [EC:6.4.1.2]
xref: EC:6.4.1.2
xref: MetaCyc:ACETYL-COA-CARBOXYLTRANSFER-RXN
xref: Reactome:REACT_100526 "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate, Oryza sativa"
xref: Reactome:REACT_100609 "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate, Rattus norvegicus"
xref: Reactome:REACT_103671 "Formation of Malonyl-CoA from Acetyl-CoA (muscle), Saccharomyces cerevisiae"
xref: Reactome:REACT_104374 "Formation of Malonyl-CoA from Acetyl-CoA (muscle), Bos taurus"
xref: Reactome:REACT_105410 "Formation of Malonyl-CoA from Acetyl-CoA (muscle), Gallus gallus"
xref: Reactome:REACT_109995 "Formation of Malonyl-CoA from Acetyl-CoA (muscle), Rattus norvegicus"
xref: Reactome:REACT_11201 "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate, Homo sapiens"
xref: Reactome:REACT_114007 "Formation of Malonyl-CoA from Acetyl-CoA (muscle), Taeniopygia guttata"
xref: Reactome:REACT_28375 "Formation of Malonyl-CoA from Acetyl-CoA (muscle), Xenopus tropicalis"
xref: Reactome:REACT_28966 "Formation of Malonyl-CoA from Acetyl-CoA (muscle), Oryza sativa"
xref: Reactome:REACT_29662 "Formation of Malonyl-CoA from Acetyl-CoA (muscle), Sus scrofa"
xref: Reactome:REACT_30959 "Formation of Malonyl-CoA from Acetyl-CoA (muscle), Drosophila melanogaster"
xref: Reactome:REACT_32583 "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate, Drosophila melanogaster"
xref: Reactome:REACT_33034 "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate, Canis familiaris"
xref: Reactome:REACT_34127 "Formation of Malonyl-CoA from Acetyl-CoA (muscle), Schizosaccharomyces pombe"
xref: Reactome:REACT_34284 "Formation of Malonyl-CoA from Acetyl-CoA (muscle), Arabidopsis thaliana"
xref: Reactome:REACT_590 "Formation of Malonyl-CoA from Acetyl-CoA (muscle), Homo sapiens"
xref: Reactome:REACT_77884 "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_80005 "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate, Danio rerio"
xref: Reactome:REACT_81142 "Formation of Malonyl-CoA from Acetyl-CoA (muscle), Dictyostelium discoideum"
xref: Reactome:REACT_84058 "Formation of Malonyl-CoA from Acetyl-CoA (muscle), Danio rerio"
xref: Reactome:REACT_87135 "Formation of Malonyl-CoA from Acetyl-CoA (muscle), Canis familiaris"
xref: Reactome:REACT_88443 "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_90395 "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate, Gallus gallus"
xref: Reactome:REACT_90662 "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate, Arabidopsis thaliana"
xref: Reactome:REACT_92102 "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate, Bos taurus"
xref: Reactome:REACT_92269 "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate, Xenopus tropicalis"
xref: Reactome:REACT_93364 "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_95365 "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate, Mus musculus"
xref: Reactome:REACT_97953 "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate, Taeniopygia guttata"
xref: Reactome:REACT_98607 "Formation of Malonyl-CoA from Acetyl-CoA (muscle), Mus musculus"
xref: Reactome:REACT_99199 "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate, Sus scrofa"
xref: RHEA:11311
is_a: GO:0016421 ! CoA carboxylase activity

[Term]
id: GO:0003990
name: acetylcholinesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetylcholine + H2O = choline + acetate." [EC:3.1.1.7]
subset: goslim_chembl
subset: gosubset_prok
synonym: "AcCholE" RELATED [EC:3.1.1.7]
synonym: "acetyl.beta-methylcholinesterase activity" EXACT [EC:3.1.1.7]
synonym: "acetylcholine acetylhydrolase activity" EXACT [EC:3.1.1.7]
synonym: "acetylcholine hydrolase activity" EXACT [EC:3.1.1.7]
synonym: "acetylthiocholinesterase activity" EXACT [EC:3.1.1.7]
synonym: "choline esterase I activity" EXACT [EC:3.1.1.7]
synonym: "true cholinesterase activity" EXACT [EC:3.1.1.7]
xref: EC:3.1.1.7
xref: MetaCyc:ACETYLCHOLINESTERASE-RXN
xref: Reactome:REACT_109174 "AcCho is hydrolysed to Cho and acetate by ACHE, Canis familiaris"
xref: Reactome:REACT_14816 "AcCho is hydrolysed to Cho and acetate by ACHE, Homo sapiens"
xref: Reactome:REACT_85985 "AcCho is hydrolysed to Cho and acetate by ACHE, Mus musculus"
xref: Reactome:REACT_89645 "AcCho is hydrolysed to Cho and acetate by ACHE, Danio rerio"
xref: Reactome:REACT_96859 "AcCho is hydrolysed to Cho and acetate by ACHE, Xenopus tropicalis"
xref: Reactome:REACT_99846 "AcCho is hydrolysed to Cho and acetate by ACHE, Bos taurus"
xref: RHEA:17564
is_a: GO:0004104 ! cholinesterase activity

[Term]
id: GO:0003991
name: acetylglutamate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate-5-phosphate." [EC:2.7.2.8]
subset: gosubset_prok
synonym: "acetylglutamate phosphokinase activity" EXACT [EC:2.7.2.8]
synonym: "ATP:N-acetyl-L-glutamate 5-phosphotransferase activity" EXACT [EC:2.7.2.8]
synonym: "N-acetylglutamate 5-phosphotransferase activity" EXACT [EC:2.7.2.8]
synonym: "N-acetylglutamate kinase activity" EXACT [EC:2.7.2.8]
synonym: "N-acetylglutamate phosphokinase activity" EXACT [EC:2.7.2.8]
synonym: "N-acetylglutamic 5-phosphotransferase activity" EXACT [EC:2.7.2.8]
xref: EC:2.7.2.8
xref: MetaCyc:ACETYLGLUTKIN-RXN
xref: RHEA:14632
is_a: GO:0016301 ! kinase activity
is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor

[Term]
id: GO:0003992
name: N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
namespace: molecular_function
alt_id: GO:0047318
def: "Catalysis of the reaction: 2-oxoglutarate + N(2)-acetyl-L-ornithine = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate." [EC:2.6.1.11, RHEA:18052]
subset: gosubset_prok
synonym: "2-N-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity" EXACT [EC:2.6.1.11]
synonym: "acetylornithine 5-aminotransferase activity" EXACT [EC:2.6.1.11]
synonym: "acetylornithine aminotransferase activity" BROAD []
synonym: "acetylornithine delta-transaminase activity" EXACT [EC:2.6.1.11]
synonym: "acetylornithine transaminase activity" BROAD [EC:2.6.1.11]
synonym: "ACOAT activity" EXACT [EC:2.6.1.11]
synonym: "N(2)-acetylornithine 5-transaminase activity" EXACT [EC:2.6.1.11]
synonym: "N-acetylornithine aminotransferase activity" EXACT [EC:2.6.1.11]
synonym: "N-acetylornithine-delta-transaminase activity" EXACT [EC:2.6.1.11]
synonym: "N2-acetyl-L-ornithine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.11]
synonym: "N2-acetylornithine 5-aminotransferase activity" EXACT []
synonym: "N2-acetylornithine 5-transaminase activity" EXACT [EC:2.6.1.11]
synonym: "succinylornithine aminotransferase activity" BROAD [EC:2.6.1.11]
xref: EC:2.6.1.11
xref: KEGG:R02283
xref: MetaCyc:ACETYLORNTRANSAM-RXN
xref: RHEA:18052
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0003993
name: acid phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]
subset: gosubset_prok
synonym: "acid monophosphatase activity" EXACT [EC:3.1.3.2]
synonym: "acid nucleoside diphosphate phosphatase activity" EXACT [EC:3.1.3.2]
synonym: "acid phosphohydrolase activity" EXACT [EC:3.1.3.2]
synonym: "acid phosphomonoester hydrolase activity" EXACT [EC:3.1.3.2]
synonym: "acid phosphomonoesterase activity" EXACT [EC:3.1.3.2]
synonym: "glycerophosphatase activity" BROAD [EC:3.1.3.2]
synonym: "orthophosphoric-monoester phosphohydrolase (acid optimum)" EXACT [EC:3.1.3.2]
synonym: "phosphate-monoester phosphohydrolase (acid optimum)" EXACT [EC:3.1.3.2]
synonym: "phosphomonoesterase activity" BROAD [EC:3.1.3.2]
synonym: "uteroferrin" RELATED [EC:3.1.3.2]
xref: EC:3.1.3.2
xref: MetaCyc:ACID-PHOSPHATASE-RXN
xref: Reactome:REACT_104847 "FMN can be hydrolyzed back to riboflavin, Mus musculus"
xref: Reactome:REACT_11171 "FMN can be hydrolyzed back to riboflavin, Homo sapiens"
xref: Reactome:REACT_80951 "FMN can be hydrolyzed back to riboflavin, Plasmodium falciparum"
xref: Reactome:REACT_82194 "FMN can be hydrolyzed back to riboflavin, Bos taurus"
xref: Reactome:REACT_82472 "FMN can be hydrolyzed back to riboflavin, Xenopus tropicalis"
xref: Reactome:REACT_83480 "FMN can be hydrolyzed back to riboflavin, Caenorhabditis elegans"
xref: Reactome:REACT_83568 "FMN can be hydrolyzed back to riboflavin, Canis familiaris"
xref: Reactome:REACT_84333 "FMN can be hydrolyzed back to riboflavin, Sus scrofa"
xref: Reactome:REACT_97154 "FMN can be hydrolyzed back to riboflavin, Danio rerio"
xref: Reactome:REACT_97735 "FMN can be hydrolyzed back to riboflavin, Arabidopsis thaliana"
xref: Reactome:REACT_99971 "FMN can be hydrolyzed back to riboflavin, Oryza sativa"
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0003994
name: aconitate hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: citrate = isocitrate. The reaction occurs in two steps: (1) citrate = cis-aconitate + H2O, (2) cis-aconitate + H2O = isocitrate. This reaction is the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate." [EC:4.2.1.3, GOC:pde, GOC:vw]
comment: This is a process composed of two reactions represented by the terms 'GO:0052632 : citrate hydro-lyase (cis-aconitate-forming) activity' and 'GO:0052633 : isocitrate hydro-lyase (cis-aconitate-forming) activity'.
subset: gosubset_prok
synonym: "aconitase activity" EXACT []
synonym: "cis-aconitase activity" EXACT [EC:4.2.1.3]
synonym: "citrate hydro-lyase activity" BROAD [EC:4.2.1.3]
synonym: "citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" EXACT [EC:4.2.1.3]
synonym: "citrate(isocitrate) hydro-lyase activity" EXACT [EC:4.2.1.3]
xref: EC:4.2.1.3
xref: Reactome:REACT_106698 "citrate <=> isocitrate, Saccharomyces cerevisiae"
xref: Reactome:REACT_115701 "citrate <=> isocitrate, Gallus gallus"
xref: Reactome:REACT_116024 "isocitrate <=> citrate, Gallus gallus"
xref: Reactome:REACT_1898 "citrate <=> isocitrate, Homo sapiens"
xref: Reactome:REACT_21262 "isocitrate <=> citrate, Homo sapiens"
xref: Reactome:REACT_30406 "citrate <=> isocitrate, Caenorhabditis elegans"
xref: Reactome:REACT_32627 "citrate <=> isocitrate, Rattus norvegicus"
xref: Reactome:REACT_46526 "citrate <=> isocitrate, Schizosaccharomyces pombe"
xref: Reactome:REACT_77059 "citrate <=> isocitrate, Bos taurus"
xref: Reactome:REACT_77875 "citrate <=> isocitrate, Canis familiaris"
xref: Reactome:REACT_77983 "citrate <=> isocitrate, Dictyostelium discoideum"
xref: Reactome:REACT_78997 "citrate <=> isocitrate, Taeniopygia guttata"
xref: Reactome:REACT_81376 "citrate <=> isocitrate, Mus musculus"
xref: Reactome:REACT_82548 "citrate <=> isocitrate, Xenopus tropicalis"
xref: Reactome:REACT_83980 "citrate <=> isocitrate, Gallus gallus"
xref: Reactome:REACT_86078 "citrate <=> isocitrate, Danio rerio"
xref: Reactome:REACT_90644 "citrate <=> isocitrate, Drosophila melanogaster"
xref: Reactome:REACT_97737 "citrate <=> isocitrate, Sus scrofa"
xref: RHEA:10339
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0003995
name: acyl-CoA dehydrogenase activity
namespace: molecular_function
alt_id: GO:0019109
def: "Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor." [EC:1.3.99.3]
subset: gosubset_prok
synonym: "acyl CoA dehydrogenase activity" EXACT [EC:1.3.99.3]
synonym: "acyl coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.3]
synonym: "acyl dehydrogenase activity" EXACT [EC:1.3.99.3]
synonym: "acyl-CoA reductase activity" EXACT [GOC:mah]
synonym: "acyl-CoA:(acceptor) 2,3-oxidoreductase activity" EXACT [EC:1.3.99.3]
synonym: "acyl-CoA:acceptor 2,3-oxidoreductase activity" EXACT [EC:1.3.99.3]
synonym: "fatty acyl coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.3]
synonym: "fatty-acyl-CoA dehydrogenase activity" EXACT [EC:1.3.99.3]
synonym: "general acyl CoA dehydrogenase activity" EXACT [EC:1.3.99.3]
synonym: "long-chain acyl coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.3]
synonym: "long-chain acyl-CoA dehydrogenase activity" EXACT [EC:1.3.99.3]
synonym: "medium-chain acyl-CoA dehydrogenase activity" NARROW [EC:1.3.99.3]
synonym: "medium-chain acyl-coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.3]
xref: EC:1.3.99.3
xref: MetaCyc:ACYLCOADEHYDROG-RXN
xref: MetaCyc:LONG-CHAIN-FATTY-ACYL-COA-REDUCTASE-RXN
xref: Reactome:REACT_100103 "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2, Bos taurus"
xref: Reactome:REACT_100162 "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2, Mus musculus"
xref: Reactome:REACT_100783 "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2, Canis familiaris"
xref: Reactome:REACT_101760 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA, Sus scrofa"
xref: Reactome:REACT_102752 "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2, Danio rerio"
xref: Reactome:REACT_102754 "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2, Drosophila melanogaster"
xref: Reactome:REACT_102759 "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2, Xenopus tropicalis"
xref: Reactome:REACT_103113 "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2, Xenopus tropicalis"
xref: Reactome:REACT_103307 "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2, Mus musculus"
xref: Reactome:REACT_103703 "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2, Taeniopygia guttata"
xref: Reactome:REACT_103943 "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2, Canis familiaris"
xref: Reactome:REACT_105107 "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2, Mycobacterium tuberculosis"
xref: Reactome:REACT_105146 "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2, Drosophila melanogaster"
xref: Reactome:REACT_105296 "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2, Xenopus tropicalis"
xref: Reactome:REACT_105300 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Sus scrofa"
xref: Reactome:REACT_106191 "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2, Mycobacterium tuberculosis"
xref: Reactome:REACT_106900 "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2, Drosophila melanogaster"
xref: Reactome:REACT_107615 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Danio rerio"
xref: Reactome:REACT_107729 "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2, Rattus norvegicus"
xref: Reactome:REACT_107750 "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2, Mus musculus"
xref: Reactome:REACT_108764 "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2, Rattus norvegicus"
xref: Reactome:REACT_108765 "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2, Rattus norvegicus"
xref: Reactome:REACT_108767 "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2, Mus musculus"
xref: Reactome:REACT_108853 "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2, Xenopus tropicalis"
xref: Reactome:REACT_108930 "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2, Mus musculus"
xref: Reactome:REACT_109051 "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2, Caenorhabditis elegans"
xref: Reactome:REACT_109106 "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2, Taeniopygia guttata"
xref: Reactome:REACT_109954 "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2, Gallus gallus"
xref: Reactome:REACT_110072 "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2, Bos taurus"
xref: Reactome:REACT_110834 "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2, Gallus gallus"
xref: Reactome:REACT_110858 "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2, Xenopus tropicalis"
xref: Reactome:REACT_1111 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA, Homo sapiens"
xref: Reactome:REACT_113088 "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2, Staphylococcus aureus N315"
xref: Reactome:REACT_113123 "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2, Staphylococcus aureus N315"
xref: Reactome:REACT_114274 "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2, Xenopus tropicalis"
xref: Reactome:REACT_1177 "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2, Homo sapiens"
xref: Reactome:REACT_1285 "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2, Homo sapiens"
xref: Reactome:REACT_1592 "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2, Homo sapiens"
xref: Reactome:REACT_1742 "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2, Homo sapiens"
xref: Reactome:REACT_1862 "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2, Homo sapiens"
xref: Reactome:REACT_1912 "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2, Homo sapiens"
xref: Reactome:REACT_2238 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Homo sapiens"
xref: Reactome:REACT_28111 "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2, Xenopus tropicalis"
xref: Reactome:REACT_28194 "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2, Bos taurus"
xref: Reactome:REACT_28196 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA, Drosophila melanogaster"
xref: Reactome:REACT_28454 "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2, Bos taurus"
xref: Reactome:REACT_28855 "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2, Taeniopygia guttata"
xref: Reactome:REACT_30090 "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2, Sus scrofa"
xref: Reactome:REACT_31237 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA, Xenopus tropicalis"
xref: Reactome:REACT_31733 "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2, Taeniopygia guttata"
xref: Reactome:REACT_31777 "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2, Mycobacterium tuberculosis"
xref: Reactome:REACT_31820 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Rattus norvegicus"
xref: Reactome:REACT_32022 "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2, Rattus norvegicus"
xref: Reactome:REACT_32213 "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2, Sus scrofa"
xref: Reactome:REACT_32236 "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2, Caenorhabditis elegans"
xref: Reactome:REACT_32631 "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2, Drosophila melanogaster"
xref: Reactome:REACT_32695 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Danio rerio"
xref: Reactome:REACT_32711 "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2, Gallus gallus"
xref: Reactome:REACT_32796 "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2, Danio rerio"
xref: Reactome:REACT_33031 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Sus scrofa"
xref: Reactome:REACT_33392 "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2, Canis familiaris"
xref: Reactome:REACT_33795 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Taeniopygia guttata"
xref: Reactome:REACT_34132 "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2, Mus musculus"
xref: Reactome:REACT_34359 "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2, Gallus gallus"
xref: Reactome:REACT_34562 "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2, Gallus gallus"
xref: Reactome:REACT_398 "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2, Homo sapiens"
xref: Reactome:REACT_43718 "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2, Bos taurus"
xref: Reactome:REACT_440 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Homo sapiens"
xref: Reactome:REACT_442 "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2, Homo sapiens"
xref: Reactome:REACT_48070 "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2, Bos taurus"
xref: Reactome:REACT_62169 "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2, Taeniopygia guttata"
xref: Reactome:REACT_630 "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2, Homo sapiens"
xref: Reactome:REACT_77605 "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2, Rattus norvegicus"
xref: Reactome:REACT_77947 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA, Canis familiaris"
xref: Reactome:REACT_79468 "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2, Danio rerio"
xref: Reactome:REACT_79535 "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2, Caenorhabditis elegans"
xref: Reactome:REACT_80706 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Rattus norvegicus"
xref: Reactome:REACT_80889 "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2, Sus scrofa"
xref: Reactome:REACT_81483 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Mus musculus"
xref: Reactome:REACT_81632 "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2, Danio rerio"
xref: Reactome:REACT_82463 "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2, Sus scrofa"
xref: Reactome:REACT_82480 "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2, Dictyostelium discoideum"
xref: Reactome:REACT_82527 "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2, Xenopus tropicalis"
xref: Reactome:REACT_82549 "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2, Caenorhabditis elegans"
xref: Reactome:REACT_82790 "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2, Mus musculus"
xref: Reactome:REACT_83350 "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2, Mus musculus"
xref: Reactome:REACT_83619 "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2, Gallus gallus"
xref: Reactome:REACT_83799 "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2, Canis familiaris"
xref: Reactome:REACT_83881 "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2, Xenopus tropicalis"
xref: Reactome:REACT_83955 "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2, Drosophila melanogaster"
xref: Reactome:REACT_83978 "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2, Taeniopygia guttata"
xref: Reactome:REACT_84492 "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2, Drosophila melanogaster"
xref: Reactome:REACT_85455 "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2, Canis familiaris"
xref: Reactome:REACT_86074 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Taeniopygia guttata"
xref: Reactome:REACT_86077 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Gallus gallus"
xref: Reactome:REACT_86174 "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2, Canis familiaris"
xref: Reactome:REACT_86330 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Mus musculus"
xref: Reactome:REACT_86360 "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2, Mycobacterium tuberculosis"
xref: Reactome:REACT_87006 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Bos taurus"
xref: Reactome:REACT_88076 "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2, Rattus norvegicus"
xref: Reactome:REACT_88615 "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2, Danio rerio"
xref: Reactome:REACT_88762 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Mycobacterium tuberculosis"
xref: Reactome:REACT_88846 "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2, Mus musculus"
xref: Reactome:REACT_89119 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA, Mycobacterium tuberculosis"
xref: Reactome:REACT_89472 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA, Taeniopygia guttata"
xref: Reactome:REACT_89523 "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2, Rattus norvegicus"
xref: Reactome:REACT_89534 "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2, Canis familiaris"
xref: Reactome:REACT_89564 "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2, Danio rerio"
xref: Reactome:REACT_89974 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA, Bos taurus"
xref: Reactome:REACT_91165 "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2, Sus scrofa"
xref: Reactome:REACT_91800 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA, Mus musculus"
xref: Reactome:REACT_92061 "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2, Sus scrofa"
xref: Reactome:REACT_92316 "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2, Canis familiaris"
xref: Reactome:REACT_92535 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Xenopus tropicalis"
xref: Reactome:REACT_92590 "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2, Bos taurus"
xref: Reactome:REACT_92851 "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2, Caenorhabditis elegans"
xref: Reactome:REACT_93155 "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2, Rattus norvegicus"
xref: Reactome:REACT_93287 "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2, Sus scrofa"
xref: Reactome:REACT_93568 "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2, Bos taurus"
xref: Reactome:REACT_93952 "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2, Mycobacterium tuberculosis"
xref: Reactome:REACT_94076 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Mycobacterium tuberculosis"
xref: Reactome:REACT_94207 "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2, Sus scrofa"
xref: Reactome:REACT_94548 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Gallus gallus"
xref: Reactome:REACT_94703 "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2, Danio rerio"
xref: Reactome:REACT_95023 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA, Danio rerio"
xref: Reactome:REACT_95378 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Xenopus tropicalis"
xref: Reactome:REACT_96588 "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2, Danio rerio"
xref: Reactome:REACT_96757 "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2, Taeniopygia guttata"
xref: Reactome:REACT_96770 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA, Rattus norvegicus"
xref: Reactome:REACT_96802 "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2, Danio rerio"
xref: Reactome:REACT_96926 "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2, Sus scrofa"
xref: Reactome:REACT_97590 "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2, Canis familiaris"
xref: Reactome:REACT_98382 "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2, Bos taurus"
xref: Reactome:REACT_98910 "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2, Dictyostelium discoideum"
xref: Reactome:REACT_99180 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA, Caenorhabditis elegans"
xref: Reactome:REACT_99352 "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2, Taeniopygia guttata"
xref: Reactome:REACT_99776 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Bos taurus"
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0003996
name: acyl-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; long-chain fatty acids have chain lengths of C13 to C22." [CHEBI:15904, EC:6.2.1.3, GOC:mah]
subset: gosubset_prok
xref: EC:6.2.1.-
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0003997
name: acyl-CoA oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide." [EC:1.3.3.6]
subset: gosubset_prok
synonym: "acyl coenzyme A oxidase activity" EXACT [EC:1.3.3.6]
synonym: "acyl-CoA:oxygen 2-oxidoreductase activity" EXACT [EC:1.3.3.6]
synonym: "fatty acyl-CoA oxidase activity" EXACT [EC:1.3.3.6]
synonym: "fatty acyl-coenzyme A oxidase activity" EXACT [EC:1.3.3.6]
xref: EC:1.3.3.6
xref: MetaCyc:ACYL-COA-OXIDASE-RXN
xref: Reactome:REACT_10003 "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA, Homo sapiens"
xref: Reactome:REACT_10074 "25(S) THCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA, Homo sapiens"
xref: Reactome:REACT_101202 "25(S) THCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA, Sus scrofa"
xref: Reactome:REACT_102703 "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA, Canis familiaris"
xref: Reactome:REACT_103315 "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2, Xenopus tropicalis"
xref: Reactome:REACT_104041 "25(S) THCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA, Bos taurus"
xref: Reactome:REACT_105955 "25(S) THCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA, Arabidopsis thaliana"
xref: Reactome:REACT_107417 "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2, Gallus gallus"
xref: Reactome:REACT_107469 "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2, Danio rerio"
xref: Reactome:REACT_109809 "25(S) THCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA, Xenopus tropicalis"
xref: Reactome:REACT_114247 "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2, Caenorhabditis elegans"
xref: Reactome:REACT_115434 "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2, Drosophila melanogaster"
xref: Reactome:REACT_17054 "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2, Homo sapiens"
xref: Reactome:REACT_28592 "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA, Xenopus tropicalis"
xref: Reactome:REACT_29191 "25(S) THCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA, Gallus gallus"
xref: Reactome:REACT_30183 "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA, Taeniopygia guttata"
xref: Reactome:REACT_30256 "25(S) THCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA, Mus musculus"
xref: Reactome:REACT_30656 "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA, Mus musculus"
xref: Reactome:REACT_33505 "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2, Bos taurus"
xref: Reactome:REACT_34639 "25(S) THCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA, Taeniopygia guttata"
xref: Reactome:REACT_34682 "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2, Rattus norvegicus"
xref: Reactome:REACT_78214 "25(S) THCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA, Oryza sativa"
xref: Reactome:REACT_78286 "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2, Taeniopygia guttata"
xref: Reactome:REACT_78800 "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA, Bos taurus"
xref: Reactome:REACT_80085 "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA, Rattus norvegicus"
xref: Reactome:REACT_81057 "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2, Oryza sativa"
xref: Reactome:REACT_81512 "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA, Gallus gallus"
xref: Reactome:REACT_86463 "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2, Canis familiaris"
xref: Reactome:REACT_86667 "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2, Sus scrofa"
xref: Reactome:REACT_89834 "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2, Mus musculus"
xref: Reactome:REACT_90722 "25(S) THCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA, Canis familiaris"
xref: Reactome:REACT_95380 "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA, Arabidopsis thaliana"
xref: Reactome:REACT_97066 "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2, Arabidopsis thaliana"
xref: Reactome:REACT_97420 "25(S) THCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA, Rattus norvegicus"
xref: Reactome:REACT_97865 "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA, Oryza sativa"
xref: Reactome:REACT_98266 "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA, Sus scrofa"
is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor

[Term]
id: GO:0003998
name: acylphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: an acyl phosphate + H2O = a carboxylate + phosphate." [EC:3.6.1.7]
subset: gosubset_prok
synonym: "1,3-diphosphoglycerate phosphatase activity" EXACT [EC:3.6.1.7]
synonym: "acetic phosphatase activity" EXACT [EC:3.6.1.7]
synonym: "acetylphosphatase activity" EXACT [EC:3.6.1.7]
synonym: "acylphosphate phosphohydrolase activity" EXACT [EC:3.6.1.7]
synonym: "GP 1-3" RELATED [EC:3.6.1.7]
synonym: "Ho 1-3" RELATED [EC:3.6.1.7]
xref: EC:3.6.1.7
xref: MetaCyc:ACYLPHOSPHATASE-RXN
xref: RHEA:14968
is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

[Term]
id: GO:0003999
name: adenine phosphoribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.7]
subset: gosubset_prok
synonym: "adenine phosphoribosylpyrophosphate transferase activity" EXACT [EC:2.4.2.7]
synonym: "adenosine phosphoribosyltransferase activity" EXACT [EC:2.4.2.7]
synonym: "adenylate pyrophosphorylase activity" EXACT [EC:2.4.2.7]
synonym: "adenylic pyrophosphorylase activity" EXACT [EC:2.4.2.7]
synonym: "AMP diphosphorylase activity" EXACT [EC:2.4.2.7]
synonym: "AMP pyrophosphorylase activity" EXACT [EC:2.4.2.7]
synonym: "AMP-pyrophosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.7]
synonym: "AMP:diphosphate phospho-D-ribosyltransferase activity" EXACT [EC:2.4.2.7]
synonym: "APRT activity" EXACT [EC:2.4.2.7]
synonym: "transphosphoribosidase activity" RELATED [EC:2.4.2.7]
xref: EC:2.4.2.7
xref: MetaCyc:ADENPRIBOSYLTRAN-RXN
xref: Reactome:REACT_101521 "Adenine + PRPP => AMP + PPi, Danio rerio"
xref: Reactome:REACT_103283 "Adenine + PRPP => AMP + PPi, Dictyostelium discoideum"
xref: Reactome:REACT_103528 "Adenine + PRPP => AMP + PPi, Bos taurus"
xref: Reactome:REACT_104835 "Adenine + PRPP => AMP + PPi, Taeniopygia guttata"
xref: Reactome:REACT_104879 "Adenine + PRPP => AMP + PPi, Caenorhabditis elegans"
xref: Reactome:REACT_165 "Adenine + PRPP => AMP + PPi, Homo sapiens"
xref: Reactome:REACT_32070 "Adenine + PRPP => AMP + PPi, Escherichia coli"
xref: Reactome:REACT_32930 "Adenine + PRPP => AMP + PPi, Mycobacterium tuberculosis"
xref: Reactome:REACT_79242 "Adenine + PRPP => AMP + PPi, Mus musculus"
xref: Reactome:REACT_84269 "Adenine + PRPP => AMP + PPi, Xenopus tropicalis"
xref: Reactome:REACT_84345 "Adenine + PRPP => AMP + PPi, Saccharomyces cerevisiae"
xref: Reactome:REACT_85331 "Adenine + PRPP => AMP + PPi, Rattus norvegicus"
xref: Reactome:REACT_87474 "Adenine + PRPP => AMP + PPi, Schizosaccharomyces pombe"
xref: Reactome:REACT_87859 "Adenine + PRPP => AMP + PPi, Sus scrofa"
xref: Reactome:REACT_88309 "Adenine + PRPP => AMP + PPi, Staphylococcus aureus N315"
xref: Reactome:REACT_90224 "Adenine + PRPP => AMP + PPi, Canis familiaris"
xref: Reactome:REACT_90510 "Adenine + PRPP => AMP + PPi, Drosophila melanogaster"
xref: RHEA:16612
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0004000
name: adenosine deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4]
subset: gosubset_prok
synonym: "adenosine aminohydrolase activity" EXACT [EC:3.5.4.4]
synonym: "adenosine deaminase reaction" EXACT []
xref: EC:3.5.4.4
xref: MetaCyc:ADENODEAMIN-RXN
xref: Reactome:REACT_107117 "(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH3 [ADA], Rattus norvegicus"
xref: Reactome:REACT_107659 "(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH3 [ADA], Gallus gallus"
xref: Reactome:REACT_113447 "(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH3 [ADA], Plasmodium falciparum"
xref: Reactome:REACT_114346 "(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH3 [ADA], Mycobacterium tuberculosis"
xref: Reactome:REACT_2135 "(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH3 [ADA], Homo sapiens"
xref: Reactome:REACT_32268 "(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH3 [ADA], Bos taurus"
xref: Reactome:REACT_34635 "(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH3 [ADA], Mus musculus"
xref: Reactome:REACT_84913 "(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH3 [ADA], Canis familiaris"
xref: Reactome:REACT_92015 "(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH3 [ADA], Caenorhabditis elegans"
xref: Reactome:REACT_93814 "(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH3 [ADA], Danio rerio"
xref: Reactome:REACT_98610 "(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH3 [ADA], Escherichia coli"
xref: RHEA:24411
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0004001
name: adenosine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + adenosine = ADP + AMP." [EC:2.7.1.20, PMID:11223943]
subset: gosubset_prok
synonym: "adenosine 5-phosphotransferase activity" EXACT []
synonym: "adenosine kinase (phosphorylating)" EXACT [EC:2.7.1.20]
synonym: "ATP:adenosine 5'-phosphotransferase activity" EXACT [EC:2.7.1.20]
xref: EC:2.7.1.20
xref: MetaCyc:ADENOSINE-KINASE-RXN
xref: Reactome:REACT_102294 "(2'-deoxy)adenosine + ATP => (d)AMP + ADP [ADK], Bos taurus"
xref: Reactome:REACT_103994 "(2'-deoxy)adenosine + ATP => (d)AMP + ADP [ADK], Dictyostelium discoideum"
xref: Reactome:REACT_110560 "(2'-deoxy)adenosine + ATP => (d)AMP + ADP [ADK], Canis familiaris"
xref: Reactome:REACT_112074 "(2'-deoxy)adenosine + ATP => (d)AMP + ADP [ADK], Oryza sativa"
xref: Reactome:REACT_114269 "(2'-deoxy)adenosine + ATP => (d)AMP + ADP [ADK], Arabidopsis thaliana"
xref: Reactome:REACT_1728 "(2'-deoxy)adenosine + ATP => (d)AMP + ADP [ADK], Homo sapiens"
xref: Reactome:REACT_32035 "(2'-deoxy)adenosine + ATP => (d)AMP + ADP [ADK], Saccharomyces cerevisiae"
xref: Reactome:REACT_32321 "(2'-deoxy)adenosine + ATP => (d)AMP + ADP [ADK], Gallus gallus"
xref: Reactome:REACT_33598 "(2'-deoxy)adenosine + ATP => (d)AMP + ADP [ADK], Xenopus tropicalis"
xref: Reactome:REACT_78205 "(2'-deoxy)adenosine + ATP => (d)AMP + ADP [ADK], Rattus norvegicus"
xref: Reactome:REACT_78906 "(2'-deoxy)adenosine + ATP => (d)AMP + ADP [ADK], Sus scrofa"
xref: Reactome:REACT_80139 "(2'-deoxy)adenosine + ATP => (d)AMP + ADP [ADK], Caenorhabditis elegans"
xref: Reactome:REACT_80336 "(2'-deoxy)adenosine + ATP => (d)AMP + ADP [ADK], Mus musculus"
xref: Reactome:REACT_86275 "(2'-deoxy)adenosine + ATP => (d)AMP + ADP [ADK], Taeniopygia guttata"
xref: Reactome:REACT_95743 "(2'-deoxy)adenosine + ATP => (d)AMP + ADP [ADK], Schizosaccharomyces pombe"
xref: Reactome:REACT_96492 "(2'-deoxy)adenosine + ATP => (d)AMP + ADP [ADK], Danio rerio"
xref: RHEA:20827
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019206 ! nucleoside kinase activity
relationship: part_of GO:0006167 ! AMP biosynthetic process

[Term]
id: GO:0004003
name: ATP-dependent DNA helicase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix." [EC:3.6.1.3, GOC:jl]
subset: gosubset_prok
is_a: GO:0003678 ! DNA helicase activity
is_a: GO:0008026 ! ATP-dependent helicase activity
is_a: GO:0008094 ! DNA-dependent ATPase activity

[Term]
id: GO:0004004
name: ATP-dependent RNA helicase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix." [EC:3.6.1.3, GOC:jl]
subset: gosubset_prok
xref: Reactome:REACT_75794 "Decay of mRNA in SMG6:SMG5:SMG7:mRNA Complex, Homo sapiens"
is_a: GO:0003724 ! RNA helicase activity
is_a: GO:0008026 ! ATP-dependent helicase activity
is_a: GO:0008186 ! RNA-dependent ATPase activity

[Term]
id: GO:0004005
name: obsolete plasma membrane cation-transporting ATPase
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it contains both component and function information.
synonym: "plasma membrane cation-transporting ATPase" EXACT []
is_obsolete: true
consider: GO:0005886
consider: GO:0019829

[Term]
id: GO:0004007
name: obsolete heavy metal-exporting ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: heavy metal ion(in) + ATP + H2O = heavy metal ion(out) + ADP + phosphate." [GOC:ai]
comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information).
synonym: "heavy metal-exporting ATPase activity" EXACT []
is_obsolete: true
consider: GO:0046873

[Term]
id: GO:0004008
name: copper-exporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) -> ADP + phosphate + Cu2+(out)." [EC:3.6.3.4]
subset: gosubset_prok
synonym: "ATP phosphohydrolase (Cu2+-exporting)" EXACT [EC:3.6.3.4]
synonym: "copper exporting ATPase activity" EXACT []
synonym: "copper-translocating P-type ATPase activity" RELATED [EC:3.6.3.4]
synonym: "Cu(2+)-exporting ATPase activity" EXACT [EC:3.6.3.4]
synonym: "Cu2+-exporting ATPase activity" EXACT [EC:3.6.3.4]
xref: EC:3.6.3.4
xref: MetaCyc:3.6.3.4-RXN
xref: Reactome:REACT_25071 "Copper export from cells by copper-transporting ATPase1, Homo sapiens"
xref: RHEA:10377
is_a: GO:0043682 ! copper-transporting ATPase activity
relationship: part_of GO:0060003 ! copper ion export

[Term]
id: GO:0004009
name: obsolete ATP-binding cassette (ABC) transporter activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because ABC transporters are a protein family rather than a functional grouping.
synonym: "ATP-binding cassette (ABC) transporter activity" EXACT []
is_obsolete: true
consider: GO:0042626
consider: GO:0043190

[Term]
id: GO:0004012
name: phospholipid-translocating ATPase activity
namespace: molecular_function
alt_id: GO:0008557
def: "Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, driven by the hydrolysis of ATP." [EC:3.6.3.1, PMID:15919184, PMID:9099684]
subset: gosubset_prok
synonym: "aminophospholipid-transporting ATPase" RELATED []
synonym: "ATP phosphohydrolase (phospholipid-flipping)" EXACT [EC:3.6.3.1]
synonym: "flippase activity" BROAD [EC:3.6.3.1]
synonym: "magnesium-ATPase activity" RELATED [EC:3.6.3.1]
synonym: "Mg(2+)-ATPase activity" RELATED [EC:3.6.3.1]
synonym: "Mg2+-ATPase activity" EXACT [EC:3.6.3.1]
synonym: "phospholipid translocating ATPase activity" EXACT []
synonym: "phospholipid-transporting ATPase activity" EXACT [EC:3.6.3.1]
synonym: "phospolipid flippase activity" EXACT []
xref: EC:3.6.3.1
xref: MetaCyc:3.6.3.1-RXN
xref: Reactome:REACT_115892 "Aminophospholipids are transported from in the internal to the external side of the plasma membrane, Homo sapiens"
xref: Reactome:REACT_24989 "P-type ATPase type IV subfamily transporters may mediate phospholipid transfer, Homo sapiens"
xref: RHEA:14992
is_a: GO:0005548 ! phospholipid transporter activity
is_a: GO:0043492 ! ATPase activity, coupled to movement of substances
relationship: part_of GO:0045332 ! phospholipid translocation

[Term]
id: GO:0004013
name: adenosylhomocysteinase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine." [EC:3.3.1.1]
subset: goslim_chembl
subset: gosubset_prok
synonym: "adenosylhomocysteine hydrolase activity" EXACT [EC:3.3.1.1]
synonym: "AdoHcyase activity" EXACT [EC:3.3.1.1]
synonym: "S-adenosyl-L-homocysteine hydrolase activity" EXACT [EC:3.3.1.1]
synonym: "S-adenosylhomocysteinase activity" EXACT [EC:3.3.1.1]
synonym: "S-adenosylhomocysteine hydrolase activity" BROAD [EC:3.3.1.1]
synonym: "S-adenosylhomocysteine synthase activity" EXACT [EC:3.3.1.1]
synonym: "SAHase activity" EXACT [EC:3.3.1.1]
xref: EC:3.3.1.1
xref: MetaCyc:ADENOSYLHOMOCYSTEINASE-RXN
xref: Reactome:REACT_100355 "S-adenoylhomocysteine is hydrolyzed, Bos taurus"
xref: Reactome:REACT_100496 "S-adenoylhomocysteine is hydrolyzed, Rattus norvegicus"
xref: Reactome:REACT_102024 "S-adenoylhomocysteine is hydrolyzed, Drosophila melanogaster"
xref: Reactome:REACT_107160 "S-adenoylhomocysteine is hydrolyzed, Canis familiaris"
xref: Reactome:REACT_109196 "S-adenoylhomocysteine is hydrolyzed, Mus musculus"
xref: Reactome:REACT_109745 "S-adenoylhomocysteine is hydrolyzed, Oryza sativa"
xref: Reactome:REACT_110610 "S-adenoylhomocysteine is hydrolyzed, Caenorhabditis elegans"
xref: Reactome:REACT_28097 "S-adenoylhomocysteine is hydrolyzed, Mycobacterium tuberculosis"
xref: Reactome:REACT_30892 "S-adenoylhomocysteine is hydrolyzed, Dictyostelium discoideum"
xref: Reactome:REACT_31016 "S-adenoylhomocysteine is hydrolyzed, Gallus gallus"
xref: Reactome:REACT_6756 "S-adenoylhomocysteine is hydrolyzed, Homo sapiens"
xref: Reactome:REACT_77798 "S-adenoylhomocysteine is hydrolyzed, Danio rerio"
xref: Reactome:REACT_77951 "S-adenoylhomocysteine is hydrolyzed, Saccharomyces cerevisiae"
xref: Reactome:REACT_80809 "S-adenoylhomocysteine is hydrolyzed, Xenopus tropicalis"
xref: Reactome:REACT_88005 "S-adenoylhomocysteine is hydrolyzed, Arabidopsis thaliana"
xref: Reactome:REACT_95489 "S-adenoylhomocysteine is hydrolyzed, Taeniopygia guttata"
xref: Reactome:REACT_99437 "S-adenoylhomocysteine is hydrolyzed, Schizosaccharomyces pombe"
xref: RHEA:21711
is_a: GO:0016802 ! trialkylsulfonium hydrolase activity

[Term]
id: GO:0004014
name: adenosylmethionine decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + H(+) = S-adenosylmethioninamine + CO(2)." [EC:4.1.1.50, RHEA:15984]
subset: gosubset_prok
synonym: "adenosyl methionine decarboxylase activity" EXACT []
synonym: "S-adenosyl-L-methionine carboxy-lyase [(5-deoxy-5-adenosyl)(3-aminopropyl)-methylsulfonium-salt-forming]" RELATED [EC:4.1.1.50]
synonym: "S-adenosyl-L-methionine carboxy-lyase activity" EXACT [EC:4.1.1.50]
synonym: "S-adenosyl-L-methionine decarboxylase activity" EXACT [EC:4.1.1.50]
synonym: "S-adenosylmethionine decarboxylase activity" EXACT [EC:4.1.1.50]
xref: EC:4.1.1.50
xref: KEGG:R00178
xref: MetaCyc:SAMDECARB-RXN
xref: Reactome:REACT_102265 "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2, Gallus gallus"
xref: Reactome:REACT_106380 "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2, Taeniopygia guttata"
xref: Reactome:REACT_106530 "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2, Caenorhabditis elegans"
xref: Reactome:REACT_108018 "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2, Dictyostelium discoideum"
xref: Reactome:REACT_109548 "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2, Canis familiaris"
xref: Reactome:REACT_110722 "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2, Sus scrofa"
xref: Reactome:REACT_14840 "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2, Homo sapiens"
xref: Reactome:REACT_28215 "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2, Danio rerio"
xref: Reactome:REACT_78516 "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2, Drosophila melanogaster"
xref: Reactome:REACT_79319 "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2, Oryza sativa"
xref: Reactome:REACT_80263 "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2, Schizosaccharomyces pombe"
xref: Reactome:REACT_81987 "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2, Arabidopsis thaliana"
xref: Reactome:REACT_89351 "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2, Mus musculus"
xref: Reactome:REACT_90930 "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2, Xenopus tropicalis"
xref: Reactome:REACT_96438 "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2, Saccharomyces cerevisiae"
xref: RHEA:15984
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004015
name: adenosylmethionine-8-amino-7-oxononanoate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 8-amino-7-oxononanoate + S-adenosyl-L-methionine(1+) = 7,8-diaminononanoate + S-adenosyl-4-methylthio-2-oxobutanoate." [EC:2.6.1.62, RHEA:16864]
subset: gosubset_prok
synonym: "7,8-diamino-pelargonic acid aminotransferase activity" EXACT [EC:2.6.1.62]
synonym: "7,8-diaminonanoate transaminase activity" EXACT [EC:2.6.1.62]
synonym: "7,8-diaminononanoate aminotransferase activity" EXACT [EC:2.6.1.62]
synonym: "7,8-diaminononanoate transaminase activity" EXACT [EC:2.6.1.62]
synonym: "7,8-diaminopelargonic acid aminotransferase activity" EXACT [EC:2.6.1.62]
synonym: "7-keto-8-aminopelargonic acid" RELATED [EC:2.6.1.62]
synonym: "7-keto-8-aminopelargonic acid aminotransferase activity" EXACT [EC:2.6.1.62]
synonym: "adenosyl methionine-8-amino-7-oxononanoate transaminase activity" EXACT []
synonym: "adenosylmethionine--8-amino-7-oxononanoate aminotransferase activity" EXACT [EC:2.6.1.62]
synonym: "adenosylmethionine-8-amino-7-oxononanoate aminotransferase activity" EXACT []
synonym: "DAPA aminotransferase activity" EXACT [EC:2.6.1.62]
synonym: "DAPA transaminase activity" EXACT [EC:2.6.1.62]
synonym: "diaminopelargonate synthase activity" EXACT [EC:2.6.1.62]
synonym: "S-adenosyl-L-methionine:8-amino-7-oxononanoate aminotransferase activity" EXACT [EC:2.6.1.62]
xref: EC:2.6.1.62
xref: KEGG:R03231
xref: MetaCyc:DAPASYN-RXN
xref: RHEA:16864
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0004016
name: adenylate cyclase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate." [EC:4.6.1.1]
subset: gosubset_prok
synonym: "3',5'-cyclic AMP synthetase activity" EXACT [EC:4.6.1.1]
synonym: "adenyl cyclase activity" EXACT [EC:4.6.1.1]
synonym: "adenylyl cyclase activity" EXACT []
synonym: "adenylylcyclase activity" EXACT [EC:4.6.1.1]
synonym: "ATP diphosphate-lyase (cyclizing) activity" EXACT [EC:4.6.1.1]
synonym: "ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming) activity" EXACT [EC:4.6.1.1]
synonym: "ATP pyrophosphate-lyase activity" EXACT [EC:4.6.1.1]
synonym: "cAMP generating peptide activity" RELATED []
xref: EC:4.6.1.1
xref: MetaCyc:ADENYLATECYC-RXN
xref: Reactome:REACT_101083 "Activated Adenylate cyclase catalyses cAMP synthesis, Gallus gallus"
xref: Reactome:REACT_103498 "Production of Cyclic AMP by Activated Adenylyl Cyclase, Sus scrofa"
xref: Reactome:REACT_104211 "Adenylate cyclase converts ATP into cyclic AMP, Drosophila melanogaster"
xref: Reactome:REACT_106348 "Activated Adenylate cyclase catalyses cAMP synthesis, Taeniopygia guttata"
xref: Reactome:REACT_110132 "Production of Cyclic AMP by Activated Adenylyl Cyclase, Bos taurus"
xref: Reactome:REACT_110346 "Adenylate cyclase converts ATP into cyclic AMP, Caenorhabditis elegans"
xref: Reactome:REACT_114273 "Production of Cyclic AMP by Activated Adenylyl Cyclase, Xenopus tropicalis"
xref: Reactome:REACT_114694 "Production of Cyclic AMP by Activated Adenylyl Cyclase, Drosophila melanogaster"
xref: Reactome:REACT_1292 "Activated Adenylate cyclase catalyses cAMP synthesis, Homo sapiens"
xref: Reactome:REACT_15399 "Adenylate cyclase converts ATP into cyclic AMP, Homo sapiens"
xref: Reactome:REACT_18321 "Production of Cyclic AMP by Activated Adenylyl Cyclase, Homo sapiens"
xref: Reactome:REACT_19249 "Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate, Homo sapiens"
xref: Reactome:REACT_19407 "Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate, Canis familiaris"
xref: Reactome:REACT_20564 "Activation of Adenylate Cyclase, Homo sapiens"
xref: Reactome:REACT_28885 "Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate, Bos taurus"
xref: Reactome:REACT_28984 "Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate, Caenorhabditis elegans"
xref: Reactome:REACT_30072 "Production of Cyclic AMP by Activated Adenylyl Cyclase, Danio rerio"
xref: Reactome:REACT_30354 "Activated Adenylate cyclase catalyses cAMP synthesis, Caenorhabditis elegans"
xref: Reactome:REACT_32296 "Adenylate cyclase converts ATP into cyclic AMP, Bos taurus"
xref: Reactome:REACT_77589 "Activated Adenylate cyclase catalyses cAMP synthesis, Danio rerio"
xref: Reactome:REACT_77648 "Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate, Danio rerio"
xref: Reactome:REACT_77920 "Adenylate cyclase converts ATP into cyclic AMP, Canis familiaris"
xref: Reactome:REACT_78464 "Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate, Taeniopygia guttata"
xref: Reactome:REACT_78878 "Production of Cyclic AMP by Activated Adenylyl Cyclase, Taeniopygia guttata"
xref: Reactome:REACT_79135 "Adenylate cyclase converts ATP into cyclic AMP, Mus musculus"
xref: Reactome:REACT_79837 "Adenylate cyclase converts ATP into cyclic AMP, Taeniopygia guttata"
xref: Reactome:REACT_80253 "Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate, Drosophila melanogaster"
xref: Reactome:REACT_80404 "Activated Adenylate cyclase catalyses cAMP synthesis, Mus musculus"
xref: Reactome:REACT_80465 "Activated Adenylate cyclase catalyses cAMP synthesis, Drosophila melanogaster"
xref: Reactome:REACT_80777 "Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate, Rattus norvegicus"
xref: Reactome:REACT_81089 "Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate, Sus scrofa"
xref: Reactome:REACT_81527 "Production of Cyclic AMP by Activated Adenylyl Cyclase, Canis familiaris"
xref: Reactome:REACT_81605 "Adenylate cyclase converts ATP into cyclic AMP, Rattus norvegicus"
xref: Reactome:REACT_84068 "Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate, Mus musculus"
xref: Reactome:REACT_84304 "Adenylate cyclase converts ATP into cyclic AMP, Gallus gallus"
xref: Reactome:REACT_84639 "Activated Adenylate cyclase catalyses cAMP synthesis, Canis familiaris"
xref: Reactome:REACT_85469 "Adenylate cyclase converts ATP into cyclic AMP, Xenopus tropicalis"
xref: Reactome:REACT_85953 "Adenylate cyclase converts ATP into cyclic AMP, Danio rerio"
xref: Reactome:REACT_86733 "Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate, Xenopus tropicalis"
xref: Reactome:REACT_87138 "Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate, Gallus gallus"
xref: Reactome:REACT_92664 "Production of Cyclic AMP by Activated Adenylyl Cyclase, Mus musculus"
xref: Reactome:REACT_92794 "Activated Adenylate cyclase catalyses cAMP synthesis, Sus scrofa"
xref: Reactome:REACT_93757 "Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate, Mycobacterium tuberculosis"
xref: Reactome:REACT_94136 "Activated Adenylate cyclase catalyses cAMP synthesis, Xenopus tropicalis"
xref: Reactome:REACT_97516 "Activated Adenylate cyclase catalyses cAMP synthesis, Bos taurus"
xref: RHEA:15392
is_a: GO:0009975 ! cyclase activity
is_a: GO:0016849 ! phosphorus-oxygen lyase activity
relationship: part_of GO:0006171 ! cAMP biosynthetic process

[Term]
id: GO:0004017
name: adenylate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + AMP = 2 ADP." [EC:2.7.4.3]
subset: gosubset_prok
synonym: "5'-AMP-kinase activity" EXACT [EC:2.7.4.3]
synonym: "adenylic kinase activity" EXACT [EC:2.7.4.3]
synonym: "adenylokinase activity" EXACT [EC:2.7.4.3]
synonym: "ATP:AMP phosphotransferase activity" EXACT [EC:2.7.4.3]
synonym: "myokinase activity" NARROW [EC:2.7.4.3]
xref: EC:2.7.4.3
xref: MetaCyc:ADENYL-KIN-RXN
xref: Reactome:REACT_100300 "AMP + ATP <=> ADP + ADP [AK2], Schizosaccharomyces pombe"
xref: Reactome:REACT_100354 "ADP + ADP <=> AMP + ATP [AK2], Dictyostelium discoideum"
xref: Reactome:REACT_100509 "(d)ADP + ADP <=> (d)AMP + ATP [AK1], Drosophila melanogaster"
xref: Reactome:REACT_100999 "ADP + ADP <=> AMP + ATP [AK2], Canis familiaris"
xref: Reactome:REACT_101925 "(d)AMP + ATP <=> (d)ADP + ADP [AK1], Canis familiaris"
xref: Reactome:REACT_101986 "ADP + ADP <=> AMP + ATP [AK2], Mus musculus"
xref: Reactome:REACT_102985 "(d)AMP + ATP <=> (d)ADP + ADP [AK1], Sus scrofa"
xref: Reactome:REACT_103652 "(d)ADP + ADP <=> (d)AMP + ATP [AK1], Mus musculus"
xref: Reactome:REACT_104314 "ADP + ADP <=> AMP + ATP [AK2], Rattus norvegicus"
xref: Reactome:REACT_106139 "ADP + ADP <=> AMP + ATP [AK2], Saccharomyces cerevisiae"
xref: Reactome:REACT_107217 "ADP + ADP <=> AMP + ATP [AK2], Taeniopygia guttata"
xref: Reactome:REACT_109890 "ADP + ADP <=> AMP + ATP [AK2], Oryza sativa"
xref: Reactome:REACT_110965 "(d)AMP + ATP <=> (d)ADP + ADP [AK1], Drosophila melanogaster"
xref: Reactome:REACT_114340 "(d)AMP + ATP <=> (d)ADP + ADP [AK1], Escherichia coli"
xref: Reactome:REACT_114949 "(d)ADP + ADP <=> (d)AMP + ATP [AK1], Escherichia coli"
xref: Reactome:REACT_2031 "ADP + ADP <=> AMP + ATP [AK2], Homo sapiens"
xref: Reactome:REACT_29050 "(d)ADP + ADP <=> (d)AMP + ATP [AK1], Danio rerio"
xref: Reactome:REACT_29136 "(d)AMP + ATP <=> (d)ADP + ADP [AK1], Caenorhabditis elegans"
xref: Reactome:REACT_31416 "AMP + ATP <=> ADP + ADP [AK2], Bos taurus"
xref: Reactome:REACT_31539 "ADP + ADP <=> AMP + ATP [AK2], Danio rerio"
xref: Reactome:REACT_32379 "(d)AMP + ATP <=> (d)ADP + ADP [AK1], Taeniopygia guttata"
xref: Reactome:REACT_32517 "AMP + ATP <=> ADP + ADP [AK2], Drosophila melanogaster"
xref: Reactome:REACT_33002 "AMP + ATP <=> ADP + ADP [AK2], Rattus norvegicus"
xref: Reactome:REACT_33987 "AMP + ATP <=> ADP + ADP [AK2], Danio rerio"
xref: Reactome:REACT_34796 "ADP + ADP <=> AMP + ATP [AK2], Bos taurus"
xref: Reactome:REACT_390 "AMP + ATP <=> ADP + ADP [AK2], Homo sapiens"
xref: Reactome:REACT_643 "(d)AMP + ATP <=> (d)ADP + ADP [AK1], Homo sapiens"
xref: Reactome:REACT_763 "(d)ADP + ADP <=> (d)AMP + ATP [AK1], Homo sapiens"
xref: Reactome:REACT_78886 "AMP + ATP <=> ADP + ADP [AK2], Gallus gallus"
xref: Reactome:REACT_78917 "(d)AMP + ATP <=> (d)ADP + ADP [AK1], Danio rerio"
xref: Reactome:REACT_79891 "(d)AMP + ATP <=> (d)ADP + ADP [AK1], Mus musculus"
xref: Reactome:REACT_80849 "AMP + ATP <=> ADP + ADP [AK2], Saccharomyces cerevisiae"
xref: Reactome:REACT_80989 "AMP + ATP <=> ADP + ADP [AK2], Dictyostelium discoideum"
xref: Reactome:REACT_82847 "AMP + ATP <=> ADP + ADP [AK2], Mus musculus"
xref: Reactome:REACT_84010 "AMP + ATP <=> ADP + ADP [AK2], Arabidopsis thaliana"
xref: Reactome:REACT_84704 "ADP + ADP <=> AMP + ATP [AK2], Xenopus tropicalis"
xref: Reactome:REACT_85367 "ADP + ADP <=> AMP + ATP [AK2], Drosophila melanogaster"
xref: Reactome:REACT_85846 "ADP + ADP <=> AMP + ATP [AK2], Gallus gallus"
xref: Reactome:REACT_87077 "(d)ADP + ADP <=> (d)AMP + ATP [AK1], Caenorhabditis elegans"
xref: Reactome:REACT_87621 "(d)ADP + ADP <=> (d)AMP + ATP [AK1], Canis familiaris"
xref: Reactome:REACT_88917 "(d)ADP + ADP <=> (d)AMP + ATP [AK1], Bos taurus"
xref: Reactome:REACT_88924 "(d)ADP + ADP <=> (d)AMP + ATP [AK1], Taeniopygia guttata"
xref: Reactome:REACT_90905 "AMP + ATP <=> ADP + ADP [AK2], Escherichia coli"
xref: Reactome:REACT_91426 "ADP + ADP <=> AMP + ATP [AK2], Caenorhabditis elegans"
xref: Reactome:REACT_91927 "AMP + ATP <=> ADP + ADP [AK2], Oryza sativa"
xref: Reactome:REACT_92343 "ADP + ADP <=> AMP + ATP [AK2], Arabidopsis thaliana"
xref: Reactome:REACT_92843 "ADP + ADP <=> AMP + ATP [AK2], Schizosaccharomyces pombe"
xref: Reactome:REACT_92937 "(d)AMP + ATP <=> (d)ADP + ADP [AK1], Xenopus tropicalis"
xref: Reactome:REACT_93851 "(d)ADP + ADP <=> (d)AMP + ATP [AK1], Xenopus tropicalis"
xref: Reactome:REACT_94373 "AMP + ATP <=> ADP + ADP [AK2], Canis familiaris"
xref: Reactome:REACT_95537 "AMP + ATP <=> ADP + ADP [AK2], Taeniopygia guttata"
xref: Reactome:REACT_96203 "AMP + ATP <=> ADP + ADP [AK2], Xenopus tropicalis"
xref: Reactome:REACT_96441 "(d)AMP + ATP <=> (d)ADP + ADP [AK1], Bos taurus"
xref: Reactome:REACT_97658 "AMP + ATP <=> ADP + ADP [AK2], Caenorhabditis elegans"
xref: Reactome:REACT_98806 "ADP + ADP <=> AMP + ATP [AK2], Escherichia coli"
xref: Reactome:REACT_99365 "(d)ADP + ADP <=> (d)AMP + ATP [AK1], Sus scrofa"
xref: RHEA:12976
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor
is_a: GO:0019201 ! nucleotide kinase activity

[Term]
id: GO:0004018
name: N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP." [EC:4.3.2.2]
subset: gosubset_prok
synonym: "6-N-(1,2-dicarboxyethyl)AMP AMP-lyase activity" EXACT [EC:4.3.2.2]
synonym: "adenylosuccinase activity" BROAD [EC:4.3.2.2, GOC:mah]
synonym: "adenylosuccinate lyase activity" BROAD [GOC:mah]
synonym: "N6-(1,2-dicarboxyethyl)AMP AMP-lyase activity" EXACT [EC:4.3.2.2]
synonym: "succino AMP-lyase activity" BROAD [EC:4.3.2.2, GOC:mah]
xref: EC:4.3.2.2
xref: KEGG:R01083
xref: MetaCyc:AMPSYN-RXN
xref: Reactome:REACT_101613 "adenylosuccinate => adenosine 5'-monophosphate + fumarate, Mycobacterium tuberculosis"
xref: Reactome:REACT_101814 "adenylosuccinate => adenosine 5'-monophosphate + fumarate, Schizosaccharomyces pombe"
xref: Reactome:REACT_102293 "SAICAR => AICAR + Fumarate, Taeniopygia guttata"
xref: Reactome:REACT_103002 "SAICAR => AICAR + Fumarate, Drosophila melanogaster"
xref: Reactome:REACT_1042 "adenylosuccinate => adenosine 5'-monophosphate + fumarate, Homo sapiens"
xref: Reactome:REACT_104702 "SAICAR => AICAR + Fumarate, Staphylococcus aureus N315"
xref: Reactome:REACT_105061 "SAICAR => AICAR + Fumarate, Gallus gallus"
xref: Reactome:REACT_106004 "adenylosuccinate => adenosine 5'-monophosphate + fumarate, Mus musculus"
xref: Reactome:REACT_115559 "adenylosuccinate => adenosine 5'-monophosphate (AMP) + fumarate, Gallus gallus"
xref: Reactome:REACT_1463 "SAICAR => AICAR + Fumarate, Homo sapiens"
xref: Reactome:REACT_28507 "SAICAR => AICAR + Fumarate, Sus scrofa"
xref: Reactome:REACT_29780 "adenylosuccinate => adenosine 5'-monophosphate + fumarate, Canis familiaris"
xref: Reactome:REACT_29974 "adenylosuccinate => adenosine 5'-monophosphate + fumarate, Xenopus tropicalis"
xref: Reactome:REACT_32835 "SAICAR => AICAR + Fumarate, Rattus norvegicus"
xref: Reactome:REACT_41804 "SAICAR => AICAR + Fumarate, Mus musculus"
xref: Reactome:REACT_80345 "SAICAR => AICAR + Fumarate, Xenopus tropicalis"
xref: Reactome:REACT_80474 "SAICAR => AICAR + Fumarate, Bos taurus"
xref: Reactome:REACT_80585 "adenylosuccinate => adenosine 5'-monophosphate + fumarate, Saccharomyces cerevisiae"
xref: Reactome:REACT_80701 "adenylosuccinate => adenosine 5'-monophosphate + fumarate, Taeniopygia guttata"
xref: Reactome:REACT_81241 "adenylosuccinate => adenosine 5'-monophosphate + fumarate, Gallus gallus"
xref: Reactome:REACT_81311 "adenylosuccinate => adenosine 5'-monophosphate + fumarate, Bos taurus"
xref: Reactome:REACT_83223 "SAICAR => AICAR + Fumarate, Caenorhabditis elegans"
xref: Reactome:REACT_84337 "adenylosuccinate => adenosine 5'-monophosphate + fumarate, Danio rerio"
xref: Reactome:REACT_85458 "SAICAR => AICAR + Fumarate, Schizosaccharomyces pombe"
xref: Reactome:REACT_87024 "adenylosuccinate => adenosine 5'-monophosphate + fumarate, Drosophila melanogaster"
xref: Reactome:REACT_88636 "adenylosuccinate => adenosine 5'-monophosphate + fumarate, Sus scrofa"
xref: Reactome:REACT_89158 "adenylosuccinate => adenosine 5'-monophosphate + fumarate, Staphylococcus aureus N315"
xref: Reactome:REACT_90078 "SAICAR => AICAR + Fumarate, Canis familiaris"
xref: Reactome:REACT_95334 "SAICAR => AICAR + Fumarate, Mycobacterium tuberculosis"
xref: Reactome:REACT_95492 "adenylosuccinate => adenosine 5'-monophosphate + fumarate, Rattus norvegicus"
xref: Reactome:REACT_99110 "adenylosuccinate => adenosine 5'-monophosphate + fumarate, Caenorhabditis elegans"
xref: Reactome:REACT_99135 "SAICAR => AICAR + Fumarate, Saccharomyces cerevisiae"
xref: Reactome:REACT_99570 "SAICAR => AICAR + Fumarate, Danio rerio"
xref: RHEA:16856
is_a: GO:0016842 ! amidine-lyase activity

[Term]
id: GO:0004019
name: adenylosuccinate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-aspartate + GTP + IMP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + 3 H(+) + phosphate." [EC:6.3.4.4, RHEA:15756]
subset: gosubset_prok
synonym: "adenylosuccinate synthetase activity" EXACT [EC:6.3.4.4]
synonym: "IMP--aspartate ligase activity" EXACT [EC:6.3.4.4]
synonym: "IMP:L-aspartate ligase (GDP-forming)" EXACT [EC:6.3.4.4]
synonym: "succino-AMP synthetase activity" EXACT [EC:6.3.4.4]
synonym: "succinoadenylic kinosynthetase activity" EXACT [EC:6.3.4.4]
xref: EC:6.3.4.4
xref: KEGG:R01135
xref: MetaCyc:ADENYLOSUCCINATE-SYNTHASE-RXN
xref: Reactome:REACT_101481 "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS], Xenopus tropicalis"
xref: Reactome:REACT_102582 "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS], Drosophila melanogaster"
xref: Reactome:REACT_106893 "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS], Plasmodium falciparum"
xref: Reactome:REACT_108314 "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS], Mus musculus"
xref: Reactome:REACT_108485 "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS], Bos taurus"
xref: Reactome:REACT_110282 "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS], Schizosaccharomyces pombe"
xref: Reactome:REACT_110567 "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS], Arabidopsis thaliana"
xref: Reactome:REACT_110657 "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS], Gallus gallus"
xref: Reactome:REACT_115645 "inosine 5'-monophosphate (IMP) + L-aspartate + GTP => adenylosuccinate + GDP + orthophosphate, Gallus gallus"
xref: Reactome:REACT_1719 "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS], Homo sapiens"
xref: Reactome:REACT_2217 "inosine 5'-monophosphate + L-aspartate + GTP => adenylosuccinate + guanosine 5'-diphosphate + orthophosphate, Mus musculus"
xref: Reactome:REACT_34115 "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS], Oryza sativa"
xref: Reactome:REACT_77813 "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS], Sus scrofa"
xref: Reactome:REACT_80422 "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS], Saccharomyces cerevisiae"
xref: Reactome:REACT_81626 "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS], Canis familiaris"
xref: Reactome:REACT_81912 "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS], Rattus norvegicus"
xref: Reactome:REACT_84271 "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS], Caenorhabditis elegans"
xref: Reactome:REACT_86165 "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS], Escherichia coli"
xref: Reactome:REACT_92014 "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS], Mycobacterium tuberculosis"
xref: Reactome:REACT_93976 "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS], Staphylococcus aureus N315"
xref: Reactome:REACT_97311 "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS], Dictyostelium discoideum"
xref: Reactome:REACT_98715 "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS], Danio rerio"
xref: Reactome:REACT_99701 "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS], Taeniopygia guttata"
xref: RHEA:15756
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0004020
name: adenylylsulfate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + adenylylsulfate = ADP + 3'-phosphoadenosine 5'-phosphosulfate." [EC:2.7.1.25]
subset: gosubset_prok
synonym: "5'-phosphoadenosine sulfate kinase activity" EXACT [EC:2.7.1.25]
synonym: "adenosine 5'-phosphosulfate kinase activity" EXACT [EC:2.7.1.25]
synonym: "adenosine phosphosulfate kinase activity" EXACT [EC:2.7.1.25]
synonym: "adenosine phosphosulfokinase activity" EXACT [EC:2.7.1.25]
synonym: "adenosine-5'-phosphosulfate 3'-phosphotransferase activity" EXACT []
synonym: "adenosine-5'-phosphosulfate-3'-phosphokinase activity" EXACT [EC:2.7.1.25]
synonym: "adenosine-5'-phosphosulphate 3'-phosphotransferase activity" EXACT []
synonym: "adenylyl-sulfate kinase activity" EXACT []
synonym: "adenylyl-sulphate kinase activity" EXACT []
synonym: "adenylylsulfate kinase (phosphorylating)" EXACT [EC:2.7.1.25]
synonym: "APS kinase activity" EXACT [EC:2.7.1.25]
synonym: "ATP:adenylyl-sulfate 3'-phosphotransferase activity" EXACT [EC:2.7.1.25]
xref: EC:2.7.1.25
xref: MetaCyc:ADENYLYLSULFKIN-RXN
xref: Reactome:REACT_102982 "adenylyl sulfate (APS) + ATP => PAPS + ADP, Mus musculus"
xref: Reactome:REACT_106160 "adenylyl sulfate (APS) + ATP => PAPS + ADP, Canis familiaris"
xref: Reactome:REACT_107506 "adenylyl sulfate (APS) + ATP => PAPS + ADP, Drosophila melanogaster"
xref: Reactome:REACT_108569 "adenylyl sulfate (APS) + ATP => PAPS + ADP, Bos taurus"
xref: Reactome:REACT_109087 "adenylyl sulfate (APS) + ATP => PAPS + ADP, Taeniopygia guttata"
xref: Reactome:REACT_109654 "adenylyl sulfate (APS) + ATP => PAPS + ADP, Gallus gallus"
xref: Reactome:REACT_112719 "adenylyl sulfate (APS) + ATP => PAPS + ADP, Escherichia coli"
xref: Reactome:REACT_27248 "APS is phosphorylated to PAPS, Mycobacterium tuberculosis"
xref: Reactome:REACT_29708 "adenylyl sulfate (APS) + ATP => PAPS + ADP, Rattus norvegicus"
xref: Reactome:REACT_30753 "adenylyl sulfate (APS) + ATP => PAPS + ADP, Xenopus tropicalis"
xref: Reactome:REACT_34307 "adenylyl sulfate (APS) + ATP => PAPS + ADP, Sus scrofa"
xref: Reactome:REACT_6792 "adenylyl sulfate (APS) + ATP => PAPS + ADP, Homo sapiens"
xref: Reactome:REACT_77453 "adenylyl sulfate (APS) + ATP => PAPS + ADP, Arabidopsis thaliana"
xref: Reactome:REACT_80762 "adenylyl sulfate (APS) + ATP => PAPS + ADP, Oryza sativa"
xref: Reactome:REACT_96385 "adenylyl sulfate (APS) + ATP => PAPS + ADP, Caenorhabditis elegans"
xref: Reactome:REACT_98813 "adenylyl sulfate (APS) + ATP => PAPS + ADP, Danio rerio"
xref: RHEA:24155
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0004021
name: L-alanine:2-oxoglutarate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate." [EC:2.6.1.2, RHEA:19456]
subset: gosubset_prok
synonym: "alanine aminotransferase activity" BROAD []
synonym: "alanine transaminase activity" BROAD [EC:2.6.1.2]
synonym: "alanine-alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.2]
synonym: "alanine-pyruvate aminotransferase activity" EXACT [EC:2.6.1.2]
synonym: "ALT" RELATED [EC:2.6.1.2]
synonym: "beta-alanine aminotransferase" BROAD [EC:2.6.1.2]
synonym: "glutamic acid-pyruvic acid transaminase activity" EXACT [EC:2.6.1.2]
synonym: "glutamic--alanine transaminase activity" EXACT [EC:2.6.1.2]
synonym: "glutamic--pyruvic transaminase activity" EXACT [EC:2.6.1.2]
synonym: "glutamic-pyruvic aminotransferase activity" EXACT [EC:2.6.1.2]
synonym: "GPT" RELATED [EC:2.6.1.2]
synonym: "L-alanine aminotransferase activity" BROAD [EC:2.6.1.2]
synonym: "L-alanine transaminase activity" BROAD [EC:2.6.1.2]
synonym: "L-alanine-alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.2]
synonym: "pyruvate transaminase activity" BROAD [EC:2.6.1.2]
synonym: "pyruvate-alanine aminotransferase activity" EXACT [EC:2.6.1.2]
synonym: "pyruvate-glutamate transaminase activity" EXACT [EC:2.6.1.2]
xref: EC:2.6.1.2
xref: KEGG:R00258
xref: MetaCyc:ALANINE-AMINOTRANSFERASE-RXN
xref: Reactome:REACT_101406 "pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT], Arabidopsis thaliana"
xref: Reactome:REACT_101725 "pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT], Bos taurus"
xref: Reactome:REACT_102570 "alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT], Canis familiaris"
xref: Reactome:REACT_104815 "alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT], Rattus norvegicus"
xref: Reactome:REACT_104823 "alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT], Caenorhabditis elegans"
xref: Reactome:REACT_106468 "alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT], Danio rerio"
xref: Reactome:REACT_110990 "pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT], Xenopus tropicalis"
xref: Reactome:REACT_196 "alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT], Homo sapiens"
xref: Reactome:REACT_21263 "alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT2], Homo sapiens"
xref: Reactome:REACT_21311 "pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT2], Homo sapiens"
xref: Reactome:REACT_29599 "alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT], Saccharomyces cerevisiae"
xref: Reactome:REACT_30303 "pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT], Danio rerio"
xref: Reactome:REACT_31969 "alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT], Bos taurus"
xref: Reactome:REACT_32776 "pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT], Mus musculus"
xref: Reactome:REACT_356 "pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT], Homo sapiens"
xref: Reactome:REACT_60750 "pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT], Caenorhabditis elegans"
xref: Reactome:REACT_78782 "alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT], Arabidopsis thaliana"
xref: Reactome:REACT_79645 "pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT], Dictyostelium discoideum"
xref: Reactome:REACT_80629 "pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT], Sus scrofa"
xref: Reactome:REACT_80730 "alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT], Oryza sativa"
xref: Reactome:REACT_82015 "pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT], Canis familiaris"
xref: Reactome:REACT_83615 "alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT], Schizosaccharomyces pombe"
xref: Reactome:REACT_87728 "pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT], Rattus norvegicus"
xref: Reactome:REACT_88275 "alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT], Sus scrofa"
xref: Reactome:REACT_88337 "pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT], Drosophila melanogaster"
xref: Reactome:REACT_89745 "pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT], Oryza sativa"
xref: Reactome:REACT_91288 "alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT], Dictyostelium discoideum"
xref: Reactome:REACT_91807 "pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT], Saccharomyces cerevisiae"
xref: Reactome:REACT_92910 "alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT], Mus musculus"
xref: Reactome:REACT_93831 "pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT], Schizosaccharomyces pombe"
xref: Reactome:REACT_94700 "alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT], Drosophila melanogaster"
xref: Reactome:REACT_99170 "alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT], Xenopus tropicalis"
xref: RHEA:19456
is_a: GO:0047635 ! alanine-oxo-acid transaminase activity

[Term]
id: GO:0004022
name: alcohol dehydrogenase (NAD) activity
namespace: molecular_function
def: "Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+." [EC:1.1.1.1]
subset: gosubset_prok
synonym: "ADH" RELATED [EC:1.1.1.1]
synonym: "alcohol dehydrogenase activity" BROAD [GOC:mah]
synonym: "alcohol:NAD+ oxidoreductase" EXACT [EC:1.1.1.1]
synonym: "aldehyde dehydrogenase (NAD) activity" NARROW []
synonym: "aldo-keto reductase (NAD) activity" EXACT []
synonym: "aliphatic alcohol dehydrogenase" NARROW [EC:1.1.1.1]
synonym: "ethanol dehydrogenase" NARROW [EC:1.1.1.1]
synonym: "NAD-dependent alcohol dehydrogenase" EXACT [EC:1.1.1.1]
synonym: "NAD-specific aromatic alcohol dehydrogenase" EXACT [EC:1.1.1.1]
synonym: "NADH-alcohol dehydrogenase" EXACT [EC:1.1.1.1]
synonym: "NADH-aldehyde dehydrogenase" EXACT [EC:1.1.1.1]
synonym: "primary alcohol dehydrogenase" BROAD [EC:1.1.1.1]
synonym: "yeast alcohol dehydrogenase" NARROW [EC:1.1.1.1]
xref: EC:1.1.1.1
xref: MetaCyc:ALCOHOL-DEHYDROG-GENERIC-RXN
xref: UM-BBD_enzymeID:e0023
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004023
name: alcohol dehydrogenase activity, metal ion-independent
namespace: molecular_function
def: "Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+; can proceed in the absence of a metal ion." [EC:1.1.1.1, GOC:mah]
is_a: GO:0004022 ! alcohol dehydrogenase (NAD) activity

[Term]
id: GO:0004024
name: alcohol dehydrogenase activity, zinc-dependent
namespace: molecular_function
def: "Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of zinc." [EC:1.1.1.1, GOC:mah]
subset: gosubset_prok
xref: Reactome:REACT_107562 "ethanol + NAD+ => acetaldehyde + NADH + H+, Gallus gallus"
xref: Reactome:REACT_1431 "ethanol + NAD+ => acetaldehyde + NADH + H+, Homo sapiens"
xref: Reactome:REACT_28919 "ethanol + NAD+ => acetaldehyde + NADH + H+, Danio rerio"
xref: Reactome:REACT_31030 "ethanol + NAD+ => acetaldehyde + NADH + H+, Rattus norvegicus"
xref: Reactome:REACT_33588 "ethanol + NAD+ => acetaldehyde + NADH + H+, Canis familiaris"
xref: Reactome:REACT_52273 "ethanol + NAD+ => acetaldehyde + NADH + H+, Sus scrofa"
xref: Reactome:REACT_90358 "ethanol + NAD+ => acetaldehyde + NADH + H+, Xenopus tropicalis"
xref: Reactome:REACT_90708 "ethanol + NAD+ => acetaldehyde + NADH + H+, Mus musculus"
xref: Reactome:REACT_92592 "ethanol + NAD+ => acetaldehyde + NADH + H+, Bos taurus"
is_a: GO:0004022 ! alcohol dehydrogenase (NAD) activity

[Term]
id: GO:0004025
name: alcohol dehydrogenase activity, iron-dependent
namespace: molecular_function
def: "Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of iron." [EC:1.1.1.1, GOC:mah]
subset: gosubset_prok
is_a: GO:0004022 ! alcohol dehydrogenase (NAD) activity

[Term]
id: GO:0004026
name: alcohol O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + an alcohol = CoA + an acetyl ester." [EC:2.3.1.84]
synonym: "AATASE activity" EXACT [EC:2.3.1.84]
synonym: "acetyl-CoA:alcohol O-acetyltransferase activity" EXACT [EC:2.3.1.84]
synonym: "alcohol acetyltransferase activity" EXACT [EC:2.3.1.84]
xref: EC:2.3.1.84
xref: MetaCyc:ALCOHOL-O-ACETYLTRANSFERASE-RXN
is_a: GO:0016413 ! O-acetyltransferase activity
is_a: GO:0034318 ! alcohol O-acyltransferase activity

[Term]
id: GO:0004027
name: alcohol sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate." [EC:2.8.2.2]
subset: goslim_chembl
subset: gosubset_prok
synonym: "3'-phosphoadenylyl-sulfate:alcohol sulfotransferase activity" EXACT [EC:2.8.2.2]
synonym: "3-hydroxysteroid sulfotransferase activity" EXACT [EC:2.8.2.2]
synonym: "3beta-hydroxy steroid sulfotransferase activity" EXACT [EC:2.8.2.2]
synonym: "3beta-hydroxysteroid sulfotransferase activity" EXACT [EC:2.8.2.2]
synonym: "5alpha-androstenol sulfotransferase activity" EXACT [EC:2.8.2.2]
synonym: "alcohol sulphotransferase activity" EXACT []
synonym: "alcohol/hydroxysteroid sulfotransferase activity" EXACT [EC:2.8.2.2]
synonym: "dehydroepiandrosterone sulfotransferase activity" EXACT [EC:2.8.2.2]
synonym: "delta5-3beta-hydroxysteroid sulfokinase activity" EXACT [EC:2.8.2.2]
synonym: "estrogen sulfokinase activity" EXACT [EC:2.8.2.2]
synonym: "estrogen sulfotransferase" BROAD [EC:2.8.2.2]
synonym: "HST" RELATED [EC:2.8.2.2]
synonym: "hydroxysteroid sulfotransferase activity" EXACT [EC:2.8.2.2]
synonym: "steroid alcohol sulfotransferase" BROAD [EC:2.8.2.2]
synonym: "steroid sulfokinase activity" EXACT [EC:2.8.2.2]
synonym: "sterol sulfokinase activity" EXACT [EC:2.8.2.2]
synonym: "sterol sulfotransferase activity" EXACT [EC:2.8.2.2]
xref: EC:2.8.2.2
xref: MetaCyc:ALCOHOL-SULFOTRANSFERASE-RXN
xref: Reactome:REACT_101584 "cholesterol + PAPS => cholesterol sulfate + PAP, Canis familiaris"
xref: Reactome:REACT_34593 "cholesterol + PAPS => cholesterol sulfate + PAP, Gallus gallus"
xref: Reactome:REACT_59193 "27-hydroxycholesterol + PAPS => 27-hydroxycholesterol 3-sulfate + PAP, Canis familiaris"
xref: Reactome:REACT_6881 "27-hydroxycholesterol + PAPS => 27-hydroxycholesterol 3-sulfate + PAP, Homo sapiens"
xref: Reactome:REACT_6957 "cholesterol + PAPS => cholesterol sulfate + PAP, Homo sapiens"
xref: Reactome:REACT_79006 "cholesterol + PAPS => cholesterol sulfate + PAP, Rattus norvegicus"
xref: Reactome:REACT_80452 "27-hydroxycholesterol + PAPS => 27-hydroxycholesterol 3-sulfate + PAP, Mus musculus"
xref: Reactome:REACT_94728 "27-hydroxycholesterol + PAPS => 27-hydroxycholesterol 3-sulfate + PAP, Gallus gallus"
xref: Reactome:REACT_95422 "cholesterol + PAPS => cholesterol sulfate + PAP, Mus musculus"
xref: Reactome:REACT_96417 "27-hydroxycholesterol + PAPS => 27-hydroxycholesterol 3-sulfate + PAP, Rattus norvegicus"
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0004028
name: 3-chloroallyl aldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-chloroallyl aldehyde + H2O = 2 H+ + 2 e- + 3-chloroacrylic acid." [UM-BBD_enzymeID:e0432]
subset: gosubset_prok
xref: EC:1.2.1.-
xref: Reactome:REACT_100428 "gamma-butyrobetaine semialdehyde + NAD+ => gamma-butyrobetaine + NADH + H+, Gallus gallus"
xref: Reactome:REACT_102182 "gamma-butyrobetaine semialdehyde + NAD+ => gamma-butyrobetaine + NADH + H+, Taeniopygia guttata"
xref: Reactome:REACT_102594 "gamma-butyrobetaine semialdehyde + NAD+ => gamma-butyrobetaine + NADH + H+, Escherichia coli"
xref: Reactome:REACT_104268 "gamma-butyrobetaine semialdehyde + NAD+ => gamma-butyrobetaine + NADH + H+, Caenorhabditis elegans"
xref: Reactome:REACT_220 "gamma-butyrobetaine semialdehyde + NAD+ => gamma-butyrobetaine + NADH + H+, Homo sapiens"
xref: Reactome:REACT_32159 "gamma-butyrobetaine semialdehyde + NAD+ => gamma-butyrobetaine + NADH + H+, Canis familiaris"
xref: Reactome:REACT_54249 "gamma-butyrobetaine semialdehyde + NAD+ => gamma-butyrobetaine + NADH + H+, Rattus norvegicus"
xref: Reactome:REACT_78707 "gamma-butyrobetaine semialdehyde + NAD+ => gamma-butyrobetaine + NADH + H+, Xenopus tropicalis"
xref: Reactome:REACT_80702 "gamma-butyrobetaine semialdehyde + NAD+ => gamma-butyrobetaine + NADH + H+, Sus scrofa"
xref: Reactome:REACT_86482 "gamma-butyrobetaine semialdehyde + NAD+ => gamma-butyrobetaine + NADH + H+, Bos taurus"
xref: Reactome:REACT_99167 "gamma-butyrobetaine semialdehyde + NAD+ => gamma-butyrobetaine + NADH + H+, Mus musculus"
xref: Reactome:REACT_99233 "gamma-butyrobetaine semialdehyde + NAD+ => gamma-butyrobetaine + NADH + H+, Danio rerio"
xref: UM-BBD_enzymeID:e0432
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004029
name: aldehyde dehydrogenase (NAD) activity
namespace: molecular_function
def: "Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+." [EC:1.2.1.3]
subset: gosubset_prok
synonym: "aldehyde dehydrogenase (NAD+)" EXACT [EC:1.2.1.3]
synonym: "aldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.3]
synonym: "CoA-independent aldehyde dehydrogenase activity" EXACT [EC:1.2.1.3]
synonym: "m-methylbenzaldehyde dehydrogenase activity" EXACT [EC:1.2.1.3]
synonym: "NAD-aldehyde dehydrogenase activity" EXACT [EC:1.2.1.3]
synonym: "NAD-dependent 4-hydroxynonenal dehydrogenase activity" EXACT [EC:1.2.1.3]
synonym: "NAD-dependent aldehyde dehydrogenase activity" EXACT [EC:1.2.1.3]
synonym: "NAD-linked aldehyde dehydrogenase activity" EXACT [EC:1.2.1.3]
synonym: "propionaldehyde dehydrogenase activity" EXACT [EC:1.2.1.3]
xref: EC:1.2.1.3
xref: MetaCyc:ALDHDEHYDROG-RXN
xref: Reactome:REACT_100473 "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic], Canis familiaris"
xref: Reactome:REACT_103621 "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid, Canis familiaris"
xref: Reactome:REACT_104849 "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial], Oryza sativa"
xref: Reactome:REACT_105050 "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial], Arabidopsis thaliana"
xref: Reactome:REACT_105669 "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid, Drosophila melanogaster"
xref: Reactome:REACT_105847 "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic], Arabidopsis thaliana"
xref: Reactome:REACT_105932 "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic], Oryza sativa"
xref: Reactome:REACT_1080 "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial], Homo sapiens"
xref: Reactome:REACT_110301 "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid, Caenorhabditis elegans"
xref: Reactome:REACT_110943 "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid, Gallus gallus"
xref: Reactome:REACT_112729 "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial], Dictyostelium discoideum"
xref: Reactome:REACT_112808 "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic], Escherichia coli"
xref: Reactome:REACT_113173 "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic], Rattus norvegicus"
xref: Reactome:REACT_113214 "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid, Dictyostelium discoideum"
xref: Reactome:REACT_113740 "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic], Mycobacterium tuberculosis"
xref: Reactome:REACT_114032 "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid, Escherichia coli"
xref: Reactome:REACT_114609 "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid, Mycobacterium tuberculosis"
xref: Reactome:REACT_115403 "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic], Dictyostelium discoideum"
xref: Reactome:REACT_15407 "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid, Homo sapiens"
xref: Reactome:REACT_16919 "pristanal + NAD+ => pristanate + NADH + H+, Homo sapiens"
xref: Reactome:REACT_2127 "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic], Homo sapiens"
xref: Reactome:REACT_30242 "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial], Bos taurus"
xref: Reactome:REACT_30317 "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial], Drosophila melanogaster"
xref: Reactome:REACT_30455 "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid, Mus musculus"
xref: Reactome:REACT_31589 "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic], Taeniopygia guttata"
xref: Reactome:REACT_34252 "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial], Mus musculus"
xref: Reactome:REACT_78762 "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid, Arabidopsis thaliana"
xref: Reactome:REACT_80267 "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid, Danio rerio"
xref: Reactome:REACT_81293 "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid, Sus scrofa"
xref: Reactome:REACT_83193 "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid, Taeniopygia guttata"
xref: Reactome:REACT_83627 "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial], Canis familiaris"
xref: Reactome:REACT_83939 "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic], Mus musculus"
xref: Reactome:REACT_84001 "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid, Rattus norvegicus"
xref: Reactome:REACT_85596 "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial], Rattus norvegicus"
xref: Reactome:REACT_86116 "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial], Sus scrofa"
xref: Reactome:REACT_86294 "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial], Caenorhabditis elegans"
xref: Reactome:REACT_86661 "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid, Bos taurus"
xref: Reactome:REACT_87336 "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial], Danio rerio"
xref: Reactome:REACT_88233 "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial], Xenopus tropicalis"
xref: Reactome:REACT_89302 "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic], Xenopus tropicalis"
xref: Reactome:REACT_89718 "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid, Xenopus tropicalis"
xref: Reactome:REACT_91587 "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial], Taeniopygia guttata"
xref: Reactome:REACT_91840 "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic], Gallus gallus"
xref: Reactome:REACT_93677 "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial], Gallus gallus"
xref: Reactome:REACT_97751 "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic], Bos taurus"
xref: Reactome:REACT_99086 "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid, Oryza sativa"
xref: RHEA:16188
xref: UM-BBD_enzymeID:e0024
xref: Wikipedia:Aldehyde_dehydrogenase_(NAD+)
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004030
name: aldehyde dehydrogenase [NAD(P)+] activity
namespace: molecular_function
def: "Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+." [EC:1.2.1.5]
subset: gosubset_prok
synonym: "aldehyde:NAD(P)+ oxidoreductase activity" EXACT [EC:1.2.1.5]
synonym: "ALDH" RELATED [EC:1.2.1.5]
xref: EC:1.2.1.5
xref: MetaCyc:ALDEHYDE-DEHYDROGENASE-NADP+-RXN
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004031
name: aldehyde oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: an aldehyde + H2O + O2 = a carboxylic acid + hydrogen peroxide." [EC:1.2.3.1]
subset: gosubset_prok
synonym: "aldehyde:oxygen oxidoreductase activity" EXACT [EC:1.2.3.1]
synonym: "quinoline oxidase activity" RELATED [EC:1.2.3.1]
xref: EC:1.2.3.1
xref: MetaCyc:ALDEHYDE-OXIDASE-RXN
xref: RHEA:16832
is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor

[Term]
id: GO:0004032
name: alditol:NADP+ 1-oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+." [EC:1.1.1.21]
subset: gosubset_prok
synonym: "aldehyde reductase activity" EXACT [EC:1.1.1.21]
synonym: "aldose reductase activity" EXACT [EC:1.1.1.21]
synonym: "polyol dehydrogenase (NADP(+)) activity" RELATED [EC:1.1.1.21]
xref: EC:1.1.1.21
xref: KEGG:R02820 "alditol:NADP+ 1-oxidoreductase"
xref: MetaCyc:ALDEHYDE-REDUCTASE-RXN
xref: Reactome:REACT_105330 "Reduction of isocaproaldehyde to 4-methylpentan-1-ol, Xenopus tropicalis"
xref: Reactome:REACT_107111 "Reduction of isocaproaldehyde to 4-methylpentan-1-ol, Drosophila melanogaster"
xref: Reactome:REACT_110163 "Reduction of isocaproaldehyde to 4-methylpentan-1-ol, Mus musculus"
xref: Reactome:REACT_112305 "Reduction of isocaproaldehyde to 4-methylpentan-1-ol, Arabidopsis thaliana"
xref: Reactome:REACT_112358 "Reduction of isocaproaldehyde to 4-methylpentan-1-ol, Dictyostelium discoideum"
xref: Reactome:REACT_114284 "Reduction of isocaproaldehyde to 4-methylpentan-1-ol, Oryza sativa"
xref: Reactome:REACT_31934 "Reduction of isocaproaldehyde to 4-methylpentan-1-ol, Bos taurus"
xref: Reactome:REACT_32005 "Reduction of isocaproaldehyde to 4-methylpentan-1-ol, Gallus gallus"
xref: Reactome:REACT_32567 "Reduction of isocaproaldehyde to 4-methylpentan-1-ol, Danio rerio"
xref: Reactome:REACT_32715 "Reduction of isocaproaldehyde to 4-methylpentan-1-ol, Canis familiaris"
xref: Reactome:REACT_91048 "Reduction of isocaproaldehyde to 4-methylpentan-1-ol, Sus scrofa"
xref: Reactome:REACT_92726 "Reduction of isocaproaldehyde to 4-methylpentan-1-ol, Saccharomyces cerevisiae"
xref: Reactome:REACT_94458 "Reduction of isocaproaldehyde to 4-methylpentan-1-ol, Rattus norvegicus"
xref: Reactome:REACT_9986 "Reduction of isocaproaldehyde to 4-methylpentan-1-ol, Homo sapiens"
is_a: GO:0008106 ! alcohol dehydrogenase (NADP+) activity

[Term]
id: GO:0004033
name: aldo-keto reductase (NADP) activity
namespace: molecular_function
def: "Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+." [GOC:ai]
subset: gosubset_prok
synonym: "alcohol dehydrogenase (NADP+) activity" NARROW []
synonym: "aldo-keto reductase (NADP+) activity" EXACT []
synonym: "aldo-keto reductase activity" EXACT []
synonym: "NADPH-dependent aldo-keto reductase activity" EXACT [GOC:vw]
xref: EC:1.1.1.-
xref: Reactome:REACT_10008 "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol, Homo sapiens"
xref: Reactome:REACT_10018 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one, Homo sapiens"
xref: Reactome:REACT_10038 "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol, Homo sapiens"
xref: Reactome:REACT_10044 "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol, Homo sapiens"
xref: Reactome:REACT_100460 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one, Canis familiaris"
xref: Reactome:REACT_10048 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one, Homo sapiens"
xref: Reactome:REACT_10054 "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol, Homo sapiens"
xref: Reactome:REACT_10068 "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol, Homo sapiens"
xref: Reactome:REACT_10086 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one, Homo sapiens"
xref: Reactome:REACT_10102 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one, Homo sapiens"
xref: Reactome:REACT_10120 "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol, Homo sapiens"
xref: Reactome:REACT_10131 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one, Homo sapiens"
xref: Reactome:REACT_101534 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one, Bos taurus"
xref: Reactome:REACT_101629 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one, Rattus norvegicus"
xref: Reactome:REACT_101931 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one, Mus musculus"
xref: Reactome:REACT_104573 "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol, Mus musculus"
xref: Reactome:REACT_104664 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one, Xenopus tropicalis"
xref: Reactome:REACT_104786 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one, Mus musculus"
xref: Reactome:REACT_105193 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one, Rattus norvegicus"
xref: Reactome:REACT_106036 "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol, Xenopus tropicalis"
xref: Reactome:REACT_106194 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one, Mus musculus"
xref: Reactome:REACT_106928 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one, Taeniopygia guttata"
xref: Reactome:REACT_108439 "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol, Mus musculus"
xref: Reactome:REACT_108757 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one, Saccharomyces cerevisiae"
xref: Reactome:REACT_110383 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one, Xenopus tropicalis"
xref: Reactome:REACT_110687 "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol, Mus musculus"
xref: Reactome:REACT_110920 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one, Canis familiaris"
xref: Reactome:REACT_11100 "Reduction of semidehydroascorbate to ascorbate, Homo sapiens"
xref: Reactome:REACT_111993 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one, Dictyostelium discoideum"
xref: Reactome:REACT_112004 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one, Dictyostelium discoideum"
xref: Reactome:REACT_112078 "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol, Drosophila melanogaster"
xref: Reactome:REACT_112094 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one, Dictyostelium discoideum"
xref: Reactome:REACT_112136 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one, Drosophila melanogaster"
xref: Reactome:REACT_112164 "Reduction of semidehydroascorbate to ascorbate, Dictyostelium discoideum"
xref: Reactome:REACT_112352 "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol, Dictyostelium discoideum"
xref: Reactome:REACT_112380 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one, Oryza sativa"
xref: Reactome:REACT_112446 "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol, Arabidopsis thaliana"
xref: Reactome:REACT_112477 "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol, Drosophila melanogaster"
xref: Reactome:REACT_112538 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one, Oryza sativa"
xref: Reactome:REACT_112546 "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol, Arabidopsis thaliana"
xref: Reactome:REACT_112547 "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol, Arabidopsis thaliana"
xref: Reactome:REACT_112635 "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol, Dictyostelium discoideum"
xref: Reactome:REACT_112765 "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol, Oryza sativa"
xref: Reactome:REACT_112786 "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol, Drosophila melanogaster"
xref: Reactome:REACT_112971 "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol, Drosophila melanogaster"
xref: Reactome:REACT_113067 "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol, Dictyostelium discoideum"
xref: Reactome:REACT_113108 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one, Dictyostelium discoideum"
xref: Reactome:REACT_113453 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one, Oryza sativa"
xref: Reactome:REACT_113482 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one, Drosophila melanogaster"
xref: Reactome:REACT_113545 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one, Drosophila melanogaster"
xref: Reactome:REACT_113590 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one, Arabidopsis thaliana"
xref: Reactome:REACT_113657 "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol, Arabidopsis thaliana"
xref: Reactome:REACT_113694 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one, Drosophila melanogaster"
xref: Reactome:REACT_113742 "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol, Dictyostelium discoideum"
xref: Reactome:REACT_113762 "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol, Oryza sativa"
xref: Reactome:REACT_113791 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one, Arabidopsis thaliana"
xref: Reactome:REACT_113879 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one, Oryza sativa"
xref: Reactome:REACT_113982 "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol, Arabidopsis thaliana"
xref: Reactome:REACT_114182 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one, Drosophila melanogaster"
xref: Reactome:REACT_114303 "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol, Arabidopsis thaliana"
xref: Reactome:REACT_114413 "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol, Oryza sativa"
xref: Reactome:REACT_114451 "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol, Oryza sativa"
xref: Reactome:REACT_114529 "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol, Drosophila melanogaster"
xref: Reactome:REACT_114561 "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol, Oryza sativa"
xref: Reactome:REACT_114574 "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol, Dictyostelium discoideum"
xref: Reactome:REACT_114601 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one, Dictyostelium discoideum"
xref: Reactome:REACT_114670 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one, Arabidopsis thaliana"
xref: Reactome:REACT_114682 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one, Oryza sativa"
xref: Reactome:REACT_114688 "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol, Drosophila melanogaster"
xref: Reactome:REACT_114788 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one, Oryza sativa"
xref: Reactome:REACT_114934 "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol, Oryza sativa"
xref: Reactome:REACT_114943 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one, Dictyostelium discoideum"
xref: Reactome:REACT_114951 "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol, Dictyostelium discoideum"
xref: Reactome:REACT_115178 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one, Drosophila melanogaster"
xref: Reactome:REACT_115352 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one, Arabidopsis thaliana"
xref: Reactome:REACT_115369 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one, Arabidopsis thaliana"
xref: Reactome:REACT_115407 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one, Arabidopsis thaliana"
xref: Reactome:REACT_28191 "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol, Saccharomyces cerevisiae"
xref: Reactome:REACT_28575 "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol, Saccharomyces cerevisiae"
xref: Reactome:REACT_28637 "Reduction of semidehydroascorbate to ascorbate, Caenorhabditis elegans"
xref: Reactome:REACT_28655 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one, Saccharomyces cerevisiae"
xref: Reactome:REACT_28677 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one, Xenopus tropicalis"
xref: Reactome:REACT_28850 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one, Canis familiaris"
xref: Reactome:REACT_28933 "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol, Xenopus tropicalis"
xref: Reactome:REACT_29682 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one, Mus musculus"
xref: Reactome:REACT_30872 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one, Gallus gallus"
xref: Reactome:REACT_31905 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one, Saccharomyces cerevisiae"
xref: Reactome:REACT_31910 "Reduction of semidehydroascorbate to ascorbate, Canis familiaris"
xref: Reactome:REACT_32080 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one, Gallus gallus"
xref: Reactome:REACT_32937 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one, Canis familiaris"
xref: Reactome:REACT_33063 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one, Bos taurus"
xref: Reactome:REACT_33464 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one, Rattus norvegicus"
xref: Reactome:REACT_77287 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one, Mus musculus"
xref: Reactome:REACT_79323 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one, Saccharomyces cerevisiae"
xref: Reactome:REACT_79627 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one, Mus musculus"
xref: Reactome:REACT_79990 "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol, Xenopus tropicalis"
xref: Reactome:REACT_81316 "Reduction of semidehydroascorbate to ascorbate, Sus scrofa"
xref: Reactome:REACT_82437 "Reduction of semidehydroascorbate to ascorbate, Danio rerio"
xref: Reactome:REACT_82926 "Reduction of semidehydroascorbate to ascorbate, Mus musculus"
xref: Reactome:REACT_82973 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one, Bos taurus"
xref: Reactome:REACT_82990 "Reduction of semidehydroascorbate to ascorbate, Taeniopygia guttata"
xref: Reactome:REACT_83001 "Reduction of semidehydroascorbate to ascorbate, Gallus gallus"
xref: Reactome:REACT_83433 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one, Saccharomyces cerevisiae"
xref: Reactome:REACT_83731 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one, Canis familiaris"
xref: Reactome:REACT_84395 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one, Rattus norvegicus"
xref: Reactome:REACT_84566 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one, Taeniopygia guttata"
xref: Reactome:REACT_84799 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one, Bos taurus"
xref: Reactome:REACT_85106 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one, Taeniopygia guttata"
xref: Reactome:REACT_85206 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one, Taeniopygia guttata"
xref: Reactome:REACT_85231 "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol, Saccharomyces cerevisiae"
xref: Reactome:REACT_85587 "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol, Saccharomyces cerevisiae"
xref: Reactome:REACT_85900 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one, Saccharomyces cerevisiae"
xref: Reactome:REACT_86109 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one, Taeniopygia guttata"
xref: Reactome:REACT_86399 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one, Rattus norvegicus"
xref: Reactome:REACT_87189 "Reduction of semidehydroascorbate to ascorbate, Bos taurus"
xref: Reactome:REACT_87397 "Reduction of semidehydroascorbate to ascorbate, Drosophila melanogaster"
xref: Reactome:REACT_87734 "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol, Saccharomyces cerevisiae"
xref: Reactome:REACT_89410 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one, Xenopus tropicalis"
xref: Reactome:REACT_90460 "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol, Xenopus tropicalis"
xref: Reactome:REACT_91267 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one, Bos taurus"
xref: Reactome:REACT_91578 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one, Taeniopygia guttata"
xref: Reactome:REACT_92005 "Reduction of semidehydroascorbate to ascorbate, Rattus norvegicus"
xref: Reactome:REACT_92354 "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol, Mus musculus"
xref: Reactome:REACT_92749 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one, Gallus gallus"
xref: Reactome:REACT_92830 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one, Bos taurus"
xref: Reactome:REACT_93550 "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol, Mus musculus"
xref: Reactome:REACT_93907 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one, Canis familiaris"
xref: Reactome:REACT_94094 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one, Xenopus tropicalis"
xref: Reactome:REACT_94919 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one, Xenopus tropicalis"
xref: Reactome:REACT_95441 "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol, Mus musculus"
xref: Reactome:REACT_95886 "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol, Saccharomyces cerevisiae"
xref: Reactome:REACT_96852 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one, Rattus norvegicus"
xref: Reactome:REACT_97815 "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol, Xenopus tropicalis"
xref: Reactome:REACT_98175 "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol, Xenopus tropicalis"
xref: Reactome:REACT_98269 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one, Gallus gallus"
xref: Reactome:REACT_98473 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one, Gallus gallus"
xref: Reactome:REACT_98695 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one, Gallus gallus"
xref: Reactome:REACT_99599 "Reduction of semidehydroascorbate to ascorbate, Xenopus tropicalis"
xref: Reactome:REACT_9972 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one, Homo sapiens"
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004034
name: aldose 1-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-glucose = beta-D-glucose. Also acts on L-arabinose, D-xylose, D-galactose, maltose and lactose." [EC:5.1.3.3]
subset: gosubset_prok
synonym: "aldose mutarotase activity" RELATED [EC:5.1.3.3]
synonym: "mutarotase activity" RELATED [EC:5.1.3.3]
xref: EC:5.1.3.3
xref: MetaCyc:ALDOSE-1-EPIMERASE-RXN
xref: RHEA:10267
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0004035
name: alkaline phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." [EC:3.1.3.1]
subset: gosubset_prok
synonym: "alkaline phenyl phosphatase activity" EXACT [EC:3.1.3.1]
synonym: "alkaline phosphohydrolase activity" EXACT [EC:3.1.3.1]
synonym: "alkaline phosphomonoesterase activity" EXACT [EC:3.1.3.1]
synonym: "glycerophosphatase activity" BROAD [EC:3.1.3.1]
synonym: "orthophosphoric-monoester phosphohydrolase (alkaline optimum)" EXACT [EC:3.1.3.1]
synonym: "phosphate-monoester phosphohydrolase (alkaline optimum)" EXACT [EC:3.1.3.1]
synonym: "phosphomonoesterase activity" BROAD [EC:3.1.3.1]
xref: EC:3.1.3.1
xref: MetaCyc:ALKAPHOSPHA-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0004037
name: allantoicase activity
namespace: molecular_function
def: "Catalysis of the reaction: allantoate + H(2)O = (S)-ureidoglycolate + urea." [EC:3.5.3.4, RHEA:11019]
subset: gosubset_prok
synonym: "allantoate amidinohydrolase activity" EXACT [EC:3.5.3.4]
synonym: "allantoine amidinohydrolase activity" EXACT []
xref: EC:3.5.3.4
xref: KEGG:R02422
xref: MetaCyc:ALLANTOICASE-RXN
xref: RHEA:11019
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0004038
name: allantoinase activity
namespace: molecular_function
def: "Catalysis of the reaction: allantoin + H2O = allantoate." [EC:3.5.2.5]
subset: gosubset_prok
synonym: "(S)-allantoin amidohydrolase activity" EXACT [EC:3.5.2.5]
xref: EC:3.5.2.5
xref: MetaCyc:ALLANTOINASE-RXN
xref: RHEA:17032
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0004039
name: allophanate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + 3 H(+) + urea-1-carboxylate = 2 CO(2) + 2 NH(4)(+)." [EC:3.5.1.54, RHEA:19032]
subset: gosubset_prok
synonym: "allophanate lyase activity" EXACT [EC:3.5.1.54]
synonym: "urea-1-carboxylate amidohydrolase activity" EXACT [EC:3.5.1.54]
xref: EC:3.5.1.54
xref: KEGG:R00005
xref: MetaCyc:ALLOPHANATE-HYDROLASE-RXN
xref: RHEA:19032
xref: UM-BBD_reactionID:r0848
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0004040
name: amidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH3." [EC:3.5.1.4]
subset: gosubset_prok
synonym: "acetamidase activity" EXACT []
synonym: "acylamidase activity" EXACT [EC:3.5.1.4]
synonym: "acylamide amidohydrolase activity" EXACT [EC:3.5.1.4]
synonym: "acylase activity" EXACT [EC:3.5.1.4]
synonym: "amidohydrolase activity" EXACT [EC:3.5.1.4]
synonym: "fatty acylamidase activity" EXACT [EC:3.5.1.4]
synonym: "N-acetylaminohydrolase activity" EXACT [EC:3.5.1.4]
xref: EC:3.5.1.4
xref: MetaCyc:AMIDASE-RXN
xref: UM-BBD_enzymeID:e0068
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0004042
name: acetyl-CoA:L-glutamate N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+)." [EC:2.3.1.1, RHEA:24295]
subset: gosubset_prok
synonym: "acetylglutamate acetylglutamate synthetase activity" EXACT [EC:2.3.1.1]
synonym: "AGAS" RELATED [EC:2.3.1.1]
synonym: "amino acid acetyltransferase activity" EXACT [EC:2.3.1.1]
synonym: "amino-acid N-acetyltransferase activity" BROAD [EC:2.3.1.1]
synonym: "N-acetylglutamate synthase activity" BROAD [EC:2.3.1.1]
xref: EC:2.3.1.1
xref: KEGG:R00259
xref: MetaCyc:N-ACETYLTRANSFER-RXN
xref: Reactome:REACT_102238 "glutamate + acetyl CoA => N-acetyl glutamate + CoA, Dictyostelium discoideum"
xref: Reactome:REACT_108325 "glutamate + acetyl CoA => N-acetyl glutamate + CoA, Mus musculus"
xref: Reactome:REACT_2139 "glutamate + acetyl CoA => N-acetyl glutamate + CoA, Homo sapiens"
xref: Reactome:REACT_29654 "glutamate + acetyl CoA => N-acetyl glutamate + CoA, Rattus norvegicus"
xref: Reactome:REACT_31801 "glutamate + acetyl CoA => N-acetyl glutamate + CoA, Canis familiaris"
xref: Reactome:REACT_81010 "glutamate + acetyl CoA => N-acetyl glutamate + CoA, Saccharomyces cerevisiae"
xref: Reactome:REACT_81256 "glutamate + acetyl CoA => N-acetyl glutamate + CoA, Bos taurus"
xref: Reactome:REACT_85183 "glutamate + acetyl CoA => N-acetyl glutamate + CoA, Schizosaccharomyces pombe"
xref: Reactome:REACT_89124 "glutamate + acetyl CoA => N-acetyl glutamate + CoA, Xenopus tropicalis"
xref: Reactome:REACT_94579 "glutamate + acetyl CoA => N-acetyl glutamate + CoA, Sus scrofa"
xref: Reactome:REACT_99960 "glutamate + acetyl CoA => N-acetyl glutamate + CoA, Danio rerio"
xref: RHEA:24295
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0004043
name: L-aminoadipate-semialdehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-2-aminoadipate 6-semialdehyde + NADP+ + H2O = L-2-aminoadipate + NADPH + H+." [EC:1.2.1.31]
subset: gosubset_prok
synonym: "2-aminoadipate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.31]
synonym: "2-aminoadipic semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.31]
synonym: "AAR" EXACT [EC:1.2.1.31]
synonym: "alpha-aminoadipate reductase activity" EXACT [EC:1.2.1.31]
synonym: "alpha-aminoadipate-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.31]
synonym: "aminoadipate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.31]
synonym: "aminoadipate-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.31]
synonym: "L-2-aminoadipate-6-semialdehyde:NAD(P)+ 6-oxidoreductase" EXACT [EC:1.2.1.31]
synonym: "L-alpha-aminoadipate delta-semialdehyde oxidoreductase activity" EXACT [EC:1.2.1.31]
synonym: "L-alpha-aminoadipate delta-semialdehyde:NAD oxidoreductase activity" EXACT [EC:1.2.1.31]
synonym: "L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase activity" EXACT [EC:1.2.1.31]
xref: EC:1.2.1.31
xref: MetaCyc:1.2.1.31-RXN
xref: Reactome:REACT_110440 "alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+, Arabidopsis thaliana"
xref: Reactome:REACT_1540 "alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+, Homo sapiens"
xref: Reactome:REACT_34232 "alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+, Danio rerio"
xref: Reactome:REACT_34396 "alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+, Mycobacterium tuberculosis"
xref: Reactome:REACT_77435 "alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+, Oryza sativa"
xref: Reactome:REACT_79544 "alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+, Dictyostelium discoideum"
xref: Reactome:REACT_80215 "alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+, Caenorhabditis elegans"
xref: Reactome:REACT_80324 "alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+, Canis familiaris"
xref: Reactome:REACT_81404 "alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+, Gallus gallus"
xref: Reactome:REACT_84541 "alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+, Sus scrofa"
xref: Reactome:REACT_86291 "alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+, Drosophila melanogaster"
xref: Reactome:REACT_88752 "alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+, Taeniopygia guttata"
xref: Reactome:REACT_92070 "alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+, Rattus norvegicus"
xref: Reactome:REACT_92791 "alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+, Bos taurus"
xref: Reactome:REACT_95793 "alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+, Xenopus tropicalis"
xref: Reactome:REACT_97958 "alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+, Mus musculus"
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004044
name: amidophosphoribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H(2)O." [EC:2.4.2.14, RHEA:14908]
subset: gosubset_prok
synonym: "5'-phosphoribosylpyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14]
synonym: "5-phosphoribosyl-1-pyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14]
synonym: "5-phosphoribosylamine:diphosphate phospho-alpha-D-ribosyltransferase (glutamate-amidating)" EXACT [EC:2.4.2.14]
synonym: "5-phosphororibosyl-1-pyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14]
synonym: "alpha-5-phosphoribosyl-1-pyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14]
synonym: "glutamine 5-phosphoribosylpyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14]
synonym: "glutamine phosphoribosyldiphosphate amidotransferase activity" EXACT [EC:2.4.2.14]
synonym: "glutamine phosphoribosylpyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14]
synonym: "glutamine ribosylpyrophosphate 5-phosphate amidotransferase activity" EXACT [EC:2.4.2.14]
synonym: "phosphoribose pyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14]
synonym: "phosphoribosyl pyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14]
synonym: "phosphoribosyldiphosphate 5-amidotransferase activity" EXACT [EC:2.4.2.14]
synonym: "phosphoribosylpyrophosphate glutamyl amidotransferase activity" EXACT [EC:2.4.2.14]
xref: EC:2.4.2.14
xref: KEGG:R01072
xref: MetaCyc:PRPPAMIDOTRANS-RXN
xref: Reactome:REACT_102786 "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate, Arabidopsis thaliana"
xref: Reactome:REACT_103149 "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate, Sus scrofa"
xref: Reactome:REACT_106474 "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_116094 "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate + pyrophosphate, Gallus gallus"
xref: Reactome:REACT_30841 "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate, Staphylococcus aureus N315"
xref: Reactome:REACT_32820 "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate, Escherichia coli"
xref: Reactome:REACT_33476 "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate, Xenopus tropicalis"
xref: Reactome:REACT_740 "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate, Homo sapiens"
xref: Reactome:REACT_76986 "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate, Danio rerio"
xref: Reactome:REACT_78155 "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate, Bos taurus"
xref: Reactome:REACT_80319 "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate, Mus musculus"
xref: Reactome:REACT_84289 "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate, Canis familiaris"
xref: Reactome:REACT_85912 "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate, Gallus gallus"
xref: Reactome:REACT_86712 "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate, Drosophila melanogaster"
xref: Reactome:REACT_87917 "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate, Oryza sativa"
xref: Reactome:REACT_90579 "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate, Mycobacterium tuberculosis"
xref: Reactome:REACT_93984 "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate, Taeniopygia guttata"
xref: Reactome:REACT_94540 "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate, Rattus norvegicus"
xref: Reactome:REACT_95631 "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_98124 "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate, Caenorhabditis elegans"
xref: Reactome:REACT_99042 "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate, Saccharomyces cerevisiae"
xref: RHEA:14908
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0004045
name: aminoacyl-tRNA hydrolase activity
namespace: molecular_function
alt_id: GO:0019850
alt_id: GO:0019851
def: "Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA." [EC:3.1.1.29]
subset: gosubset_prok
synonym: "aminoacyl-transfer ribonucleate hydrolase activity" EXACT [EC:3.1.1.29]
synonym: "aminoacyl-tRNA aminoacylhydrolase activity" EXACT [EC:3.1.1.29]
synonym: "aminoacyl-tRNA hydrolase reaction" EXACT []
synonym: "D-tyrosyl-tRNA hydrolase activity" NARROW [PMID:15292242]
synonym: "N-substituted aminoacyl transfer RNA hydrolase activity" EXACT [EC:3.1.1.29]
synonym: "peptidyl-tRNA hydrolase activity" EXACT [EC:3.1.1.29]
xref: EC:3.1.1.29
xref: MetaCyc:AMINOCYL-TRNA-HYDROLASE-RXN
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0004046
name: aminoacylase activity
namespace: molecular_function
def: "Catalysis of the reaction: an N-acyl-L-amino acid + H2O = a carboxylate + an L-amino acid." [EC:3.5.1.14]
subset: gosubset_prok
synonym: "acylase I activity" NARROW [EC:3.5.1.14]
synonym: "alpha-N-acylaminoacid hydrolase activity" EXACT [EC:3.5.1.14]
synonym: "amido acid deacylase activity" EXACT [EC:3.5.1.14]
synonym: "aminoacylase I activity" NARROW [EC:3.5.1.14]
synonym: "benzamidase activity" RELATED [EC:3.5.1.14]
synonym: "dehydropeptidase II activity" NARROW [EC:3.5.1.14]
synonym: "hippurase activity" EXACT [EC:3.5.1.14]
synonym: "histozyme activity" RELATED [EC:3.5.1.14]
synonym: "L-amino-acid acylase activity" EXACT [EC:3.5.1.14]
synonym: "L-aminoacylase activity" EXACT [EC:3.5.1.14]
synonym: "long acyl amidoacylase activity" EXACT [EC:3.5.1.14]
synonym: "N-acyl-L-amino-acid amidohydrolase activity" EXACT [EC:3.5.1.14]
synonym: "short acyl amidoacylase activity" EXACT [EC:3.5.1.14]
xref: EC:3.5.1.14
xref: MetaCyc:AMINOACYLASE-RXN
xref: RHEA:15568
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0004047
name: aminomethyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein." [EC:2.1.2.10]
subset: gosubset_prok
synonym: "glycine synthase activity" RELATED [EC:2.1.2.10]
synonym: "glycine-cleavage system T-protein activity" RELATED [EC:2.1.2.10]
synonym: "protein-8-S-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming) activity" EXACT [EC:2.1.2.10]
synonym: "protein-S8-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming) activity" EXACT [EC:2.1.2.10]
synonym: "S-aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) activity" EXACT [EC:2.1.2.10]
synonym: "T-protein" RELATED [EC:2.1.2.10]
synonym: "tetrahydrofolate aminomethyltransferase activity" EXACT [EC:2.1.2.10]
xref: EC:2.1.2.10
xref: MetaCyc:GCVT-RXN
xref: RHEA:16948
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0004048
name: anthranilate phosphoribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate." [EC:2.4.2.18, RHEA:11771]
subset: gosubset_prok
synonym: "anthranilate 5-phosphoribosylpyrophosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.18]
synonym: "anthranilate phosphoribosylpyrophosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.18]
synonym: "anthranilate-PP-ribose-P phosphoribosyltransferase activity" EXACT [EC:2.4.2.18]
synonym: "N-(5-phospho-D-ribosyl)-anthranilate:diphosphate phospho-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.18]
synonym: "phosphoribosyl-anthranilate diphosphorylase activity" EXACT [EC:2.4.2.18]
synonym: "phosphoribosyl-anthranilate pyrophosphorylase activity" EXACT [EC:2.4.2.18]
synonym: "phosphoribosylanthranilate pyrophosphorylase activity" EXACT [EC:2.4.2.18]
synonym: "phosphoribosylanthranilate transferase activity" EXACT [EC:2.4.2.18]
synonym: "PRT" RELATED [EC:2.4.2.18]
xref: EC:2.4.2.18
xref: KEGG:R01073
xref: MetaCyc:PRTRANS-RXN
xref: RHEA:11771
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0004049
name: anthranilate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate." [EC:4.1.3.27]
subset: gosubset_prok
synonym: "anthranilate synthetase activity" EXACT [EC:4.1.3.27]
synonym: "chorismate pyruvate-lyase (amino-accepting) activity" EXACT [EC:4.1.3.27]
xref: EC:4.1.3.27
xref: MetaCyc:ANTHRANSYN-RXN
xref: RHEA:21735
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0004050
name: obsolete apyrase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + 2 H2O = AMP + 2 phosphate." [EC:3.6.1.5, MetaCyc:APYRASE-RXN]
comment: This term was made obsolete because it represents a gene product which can catalyze two reactions.
synonym: "apyrase activity" EXACT []
is_obsolete: true
consider: GO:0017110
consider: GO:0017111

[Term]
id: GO:0004051
name: arachidonate 5-lipoxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: arachidonate + O2 = (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxycosa-6,8,11,14-tetraenoate." [EC:1.13.11.34]
subset: gosubset_prok
synonym: "5-delta-lipoxygenase activity" EXACT [EC:1.13.11.34]
synonym: "5-lipoxygenase activity" EXACT [EC:1.13.11.34]
synonym: "5Delta-lipoxygenase activity" EXACT [EC:1.13.11.34]
synonym: "arachidonate:oxygen 5-oxidoreductase activity" EXACT [EC:1.13.11.34]
synonym: "arachidonic 5-lipoxygenase activity" EXACT [EC:1.13.11.34]
synonym: "arachidonic acid 5-lipoxygenase activity" EXACT [EC:1.13.11.34]
synonym: "C-5-lipoxygenase activity" RELATED [EC:1.13.11.34]
synonym: "delta(5)-lipoxygenase activity" RELATED [EC:1.13.11.34]
synonym: "delta5-lipoxygenase activity" EXACT [EC:1.13.11.34]
synonym: "leukotriene A4 synthase" BROAD [EC:1.13.11.34]
synonym: "leukotriene-A(4) synthase activity" NARROW [EC:1.13.11.34]
synonym: "leukotriene-A4 synthase activity" EXACT [EC:1.13.11.34]
synonym: "LTA synthase activity" NARROW [EC:1.13.11.34]
xref: EC:1.13.11.34
xref: MetaCyc:ARACHIDONATE-5-LIPOXYGENASE-RXN
xref: Reactome:REACT_101081 "Oxidation of arachidonic acid to 5-HpETE, Sus scrofa"
xref: Reactome:REACT_102776 "Dehydration of 5-HpETE to leukotriene A4, Bos taurus"
xref: Reactome:REACT_104725 "Dehydration of 5-HpETE to leukotriene A4, Gallus gallus"
xref: Reactome:REACT_107795 "Oxidation of arachidonic acid to 5-HpETE, Gallus gallus"
xref: Reactome:REACT_107991 "Dehydration of 5-HpETE to leukotriene A4, Rattus norvegicus"
xref: Reactome:REACT_109247 "Oxidation of arachidonic acid to 5-HpETE, Rattus norvegicus"
xref: Reactome:REACT_110901 "Oxidation of arachidonic acid to 5-HpETE, Danio rerio"
xref: Reactome:REACT_113814 "Dehydration of 5-HpETE to leukotriene A4, Dictyostelium discoideum"
xref: Reactome:REACT_115370 "Oxidation of arachidonic acid to 5-HpETE, Dictyostelium discoideum"
xref: Reactome:REACT_15337 "Oxidation of arachidonic acid to 5-HpETE, Homo sapiens"
xref: Reactome:REACT_15453 "Dehydration of 5-HpETE to leukotriene A4, Homo sapiens"
xref: Reactome:REACT_28749 "Oxidation of arachidonic acid to 5-HpETE, Canis familiaris"
xref: Reactome:REACT_76963 "Dehydration of 5-HpETE to leukotriene A4, Canis familiaris"
xref: Reactome:REACT_77245 "Oxidation of arachidonic acid to 5-HpETE, Taeniopygia guttata"
xref: Reactome:REACT_78626 "Oxidation of arachidonic acid to 5-HpETE, Xenopus tropicalis"
xref: Reactome:REACT_79548 "Dehydration of 5-HpETE to leukotriene A4, Danio rerio"
xref: Reactome:REACT_80928 "Oxidation of arachidonic acid to 5-HpETE, Mus musculus"
xref: Reactome:REACT_84095 "Dehydration of 5-HpETE to leukotriene A4, Taeniopygia guttata"
xref: Reactome:REACT_84894 "Dehydration of 5-HpETE to leukotriene A4, Sus scrofa"
xref: Reactome:REACT_87806 "Dehydration of 5-HpETE to leukotriene A4, Xenopus tropicalis"
xref: Reactome:REACT_90210 "Oxidation of arachidonic acid to 5-HpETE, Bos taurus"
xref: Reactome:REACT_99738 "Dehydration of 5-HpETE to leukotriene A4, Mus musculus"
xref: RHEA:24751
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0004052
name: arachidonate 12-lipoxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: arachidonate + O(2) = (5Z,8Z,10E,12S,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoate." [EC:1.13.11.31, RHEA:10431]
synonym: "12-lipoxygenase activity" RELATED [EC:1.13.11.31]
synonym: "12Delta-lipoxygenase activity" EXACT [EC:1.13.11.31]
synonym: "12S-lipoxygenase activity" EXACT [EC:1.13.11.31]
synonym: "arachidonate:oxygen 12-oxidoreductase activity" EXACT [EC:1.13.11.31]
synonym: "C-12 lipoxygenase activity" EXACT [EC:1.13.11.31]
synonym: "delta12-lipoxygenase activity" EXACT [EC:1.13.11.31]
synonym: "leukotriene A4 synthase" BROAD [EC:1.13.11.31]
synonym: "LTA4 synthase activity" EXACT [EC:1.13.11.31]
xref: EC:1.13.11.31
xref: KEGG:R01596
xref: MetaCyc:ARACHIDONATE-12-LIPOXYGENASE-RXN
xref: RHEA:10431
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0004053
name: arginase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arginine + H2O = L-ornithine + urea." [EC:3.5.3.1]
subset: gosubset_prok
synonym: "arginine amidinase activity" EXACT [EC:3.5.3.1]
synonym: "arginine transamidinase activity" EXACT [EC:3.5.3.1]
synonym: "canavanase activity" EXACT [EC:3.5.3.1]
synonym: "L-arginase activity" EXACT [EC:3.5.3.1]
synonym: "L-arginine amidinohydrolase activity" EXACT [EC:3.5.3.1]
xref: EC:3.5.3.1
xref: MetaCyc:ARGINASE-RXN
xref: Reactome:REACT_104545 "arginine + H2O => ornithine + urea [ARG1], Mus musculus"
xref: Reactome:REACT_105138 "arginine + H2O => ornithine + urea [ARG1], Saccharomyces cerevisiae"
xref: Reactome:REACT_105399 "arginine + H2O => ornithine + urea [ARG1], Rattus norvegicus"
xref: Reactome:REACT_112789 "arginine + H2O => ornithine + urea [ARG1], Caenorhabditis elegans"
xref: Reactome:REACT_115584 "arginine + H2O => ornithine + urea, Gallus gallus"
xref: Reactome:REACT_21325 "arginine + H2O => ornithine + urea [ARG2], Homo sapiens"
xref: Reactome:REACT_29262 "arginine + H2O => ornithine + urea [ARG1], Drosophila melanogaster"
xref: Reactome:REACT_394 "arginine + H2O => ornithine + urea [ARG1], Homo sapiens"
xref: Reactome:REACT_80504 "arginine + H2O => ornithine + urea [ARG1], Sus scrofa"
xref: Reactome:REACT_83897 "arginine + H2O => ornithine + urea [ARG1], Plasmodium falciparum"
xref: Reactome:REACT_84916 "arginine + H2O => ornithine + urea [ARG1], Canis familiaris"
xref: Reactome:REACT_94417 "arginine + H2O => ornithine + urea [ARG1], Xenopus tropicalis"
xref: Reactome:REACT_94917 "arginine + H2O => ornithine + urea [ARG1], Schizosaccharomyces pombe"
xref: Reactome:REACT_99000 "arginine + H2O => ornithine + urea [ARG1], Bos taurus"
xref: Reactome:REACT_99109 "arginine + H2O => ornithine + urea [ARG1], Staphylococcus aureus N315"
xref: Reactome:REACT_99872 "arginine + H2O => ornithine + urea [ARG1], Danio rerio"
xref: RHEA:20572
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0004054
name: arginine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arginine + ATP = N(omega)-phospho-L-arginine + ADP + 2 H(+)." [EC:2.7.3.3, RHEA:22943]
synonym: "adenosine 5'-triphosphate-arginine phosphotransferase activity" EXACT [EC:2.7.3.3]
synonym: "adenosine 5'-triphosphate:L-arginine" RELATED [EC:2.7.3.3]
synonym: "arginine phosphokinase activity" EXACT [EC:2.7.3.3]
synonym: "ATP:L-arginine N-phosphotransferase activity" EXACT [EC:2.7.3.3]
xref: EC:2.7.3.3
xref: KEGG:R00554
xref: MetaCyc:ARGININE-KINASE-RXN
xref: RHEA:22943
is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor
is_a: GO:0019202 ! amino acid kinase activity

[Term]
id: GO:0004055
name: argininosuccinate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate." [EC:6.3.4.5]
subset: gosubset_prok
synonym: "arginine succinate synthetase activity" EXACT [EC:6.3.4.5]
synonym: "argininosuccinate synthetase activity" EXACT [EC:6.3.4.5]
synonym: "argininosuccinic acid synthetase activity" EXACT [EC:6.3.4.5]
synonym: "arginosuccinate synthetase activity" EXACT [EC:6.3.4.5]
synonym: "citrulline--aspartate ligase activity" EXACT [EC:6.3.4.5]
synonym: "L-citrulline:L-aspartate ligase (AMP-forming)" EXACT [EC:6.3.4.5]
xref: EC:6.3.4.5
xref: MetaCyc:ARGSUCCINSYN-RXN
xref: Reactome:REACT_102781 "ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate, Canis familiaris"
xref: Reactome:REACT_102882 "ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate, Mycobacterium tuberculosis"
xref: Reactome:REACT_110988 "ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate, Arabidopsis thaliana"
xref: Reactome:REACT_113640 "ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate, Gallus gallus"
xref: Reactome:REACT_115870 "ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate, Gallus gallus"
xref: Reactome:REACT_29799 "ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_31033 "ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate, Drosophila melanogaster"
xref: Reactome:REACT_482 "ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate, Homo sapiens"
xref: Reactome:REACT_77511 "ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate, Danio rerio"
xref: Reactome:REACT_78098 "ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate, Oryza sativa"
xref: Reactome:REACT_82273 "ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate, Rattus norvegicus"
xref: Reactome:REACT_85713 "ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate, Sus scrofa"
xref: Reactome:REACT_93966 "ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_94014 "ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate, Bos taurus"
xref: Reactome:REACT_94088 "ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate, Taeniopygia guttata"
xref: Reactome:REACT_95275 "ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate, Xenopus tropicalis"
xref: Reactome:REACT_98246 "ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate, Mus musculus"
xref: Reactome:REACT_98815 "ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate, Escherichia coli"
xref: Reactome:REACT_99835 "ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate, Staphylococcus aureus N315"
xref: RHEA:10935
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0004056
name: argininosuccinate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine." [EC:4.3.2.1]
subset: gosubset_prok
synonym: "2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)" EXACT [EC:4.3.2.1]
synonym: "2-(omega-N-L-arginino)succinate arginine-lyase (fumarate-forming)" EXACT [EC:4.3.2.1]
synonym: "arginine-succinate lyase activity" EXACT [EC:4.3.2.1]
synonym: "argininosuccinic acid lyase activity" EXACT [EC:4.3.2.1]
synonym: "arginosuccinase activity" EXACT [EC:4.3.2.1]
synonym: "N-(L-argininosuccinate) arginine-lyase activity" EXACT [EC:4.3.2.1]
synonym: "omega-N-(L-arginino)succinate arginine-lyase activity" EXACT [EC:4.3.2.1]
xref: EC:4.3.2.1
xref: MetaCyc:ARGSUCCINLYA-RXN
xref: Reactome:REACT_105702 "argininosuccinate <=> fumarate + arginine, Xenopus tropicalis"
xref: Reactome:REACT_107201 "argininosuccinate <=> fumarate + arginine, Taeniopygia guttata"
xref: Reactome:REACT_107341 "argininosuccinate <=> fumarate + arginine, Rattus norvegicus"
xref: Reactome:REACT_107497 "argininosuccinate <=> fumarate + arginine, Sus scrofa"
xref: Reactome:REACT_108281 "argininosuccinate <=> fumarate + arginine, Canis familiaris"
xref: Reactome:REACT_110613 "argininosuccinate <=> fumarate + arginine, Saccharomyces cerevisiae"
xref: Reactome:REACT_113182 "argininosuccinate <=> fumarate + arginine, Staphylococcus aureus N315"
xref: Reactome:REACT_114192 "argininosuccinate <=> fumarate + arginine, Arabidopsis thaliana"
xref: Reactome:REACT_114884 "argininosuccinate <=> fumarate + arginine, Escherichia coli"
xref: Reactome:REACT_115252 "argininosuccinate <=> fumarate + arginine, Oryza sativa"
xref: Reactome:REACT_116009 "argininosuccinate <=> fumarate + arginine, Gallus gallus"
xref: Reactome:REACT_1378 "argininosuccinate <=> fumarate + arginine, Homo sapiens"
xref: Reactome:REACT_79360 "argininosuccinate <=> fumarate + arginine, Schizosaccharomyces pombe"
xref: Reactome:REACT_79752 "argininosuccinate <=> fumarate + arginine, Drosophila melanogaster"
xref: Reactome:REACT_83325 "argininosuccinate <=> fumarate + arginine, Gallus gallus"
xref: Reactome:REACT_92799 "argininosuccinate <=> fumarate + arginine, Mycobacterium tuberculosis"
xref: Reactome:REACT_94002 "argininosuccinate <=> fumarate + arginine, Danio rerio"
xref: Reactome:REACT_98490 "argininosuccinate <=> fumarate + arginine, Mus musculus"
xref: Reactome:REACT_98521 "argininosuccinate <=> fumarate + arginine, Bos taurus"
xref: RHEA:24023
is_a: GO:0016842 ! amidine-lyase activity

[Term]
id: GO:0004057
name: arginyltransferase activity
namespace: molecular_function
alt_id: GO:0042172
def: "Catalysis of the reaction: L-arginyl-tRNA + protein = tRNA + L-arginyl-protein." [EC:2.3.2.8]
subset: gosubset_prok
synonym: "arginine transferase activity" EXACT [EC:2.3.2.8]
synonym: "arginyl-transfer ribonucleate-protein aminoacyltransferase activity" EXACT [EC:2.3.2.8]
synonym: "arginyl-transfer ribonucleate-protein transferase activity" EXACT [EC:2.3.2.8]
synonym: "arginyl-tRNA protein transferase activity" EXACT [EC:2.3.2.8]
synonym: "arginyl-tRNA--protein transferase activity" EXACT [EC:2.3.2.8]
synonym: "arginyl-tRNA-protein transferase activity" EXACT []
synonym: "L-arginyl-tRNA:protein arginyltransferase activity" EXACT [EC:2.3.2.8]
xref: EC:2.3.2.8
xref: MetaCyc:ARGINYLTRANSFERASE-RXN
is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups

[Term]
id: GO:0004058
name: aromatic-L-amino-acid decarboxylase activity
namespace: molecular_function
alt_id: GO:0016400
def: "Catalysis of the reaction: L-amino acid + H+ = R-H + CO2." [EC:4.1.1.28]
synonym: "5-hydroxytryptophan decarboxylase activity" NARROW [EC:4.1.1.28]
synonym: "aromatic amino acid decarboxylase activity" EXACT [EC:4.1.1.28]
synonym: "aromatic-L-amino-acid carboxy-lyase (tryptamine-forming)" NARROW [EC:4.1.1.28]
synonym: "aromatic-L-amino-acid carboxy-lyase activity" EXACT [EC:4.1.1.28]
synonym: "DOPA decarboxylase activity" NARROW [EC:4.1.1.28]
synonym: "hydroxytryptophan decarboxylase activity" NARROW [EC:4.1.1.28]
synonym: "L-DOPA decarboxylase activity" NARROW [EC:4.1.1.28]
synonym: "tryptophan decarboxylase activity" NARROW [EC:4.1.1.28]
xref: EC:4.1.1.28
xref: MetaCyc:AROMATIC-L-AMINO-ACID-DECARBOXYLASE-RXN
xref: Reactome:REACT_102788 "Decarboxylation of 5-hydroxytryptophan forms serotonin, Rattus norvegicus"
xref: Reactome:REACT_104092 "Decarboxylation of 5-hydroxytryptophan forms serotonin, Bos taurus"
xref: Reactome:REACT_107239 "Decarboxylation of 5-hydroxytryptophan forms serotonin, Xenopus tropicalis"
xref: Reactome:REACT_109359 "Decarboxylation of 5-hydroxytryptophan forms serotonin, Canis familiaris"
xref: Reactome:REACT_110116 "Dopa is decarboxylated to dopamine, Arabidopsis thaliana"
xref: Reactome:REACT_110361 "Dopa is decarboxylated to dopamine, Taeniopygia guttata"
xref: Reactome:REACT_15382 "Dopa is decarboxylated to dopamine, Homo sapiens"
xref: Reactome:REACT_15546 "Decarboxylation of 5-hydroxytryptophan forms serotonin, Homo sapiens"
xref: Reactome:REACT_29601 "Decarboxylation of 5-hydroxytryptophan forms serotonin, Taeniopygia guttata"
xref: Reactome:REACT_32557 "Decarboxylation of 5-hydroxytryptophan forms serotonin, Drosophila melanogaster"
xref: Reactome:REACT_32559 "Decarboxylation of 5-hydroxytryptophan forms serotonin, Sus scrofa"
xref: Reactome:REACT_32861 "Dopa is decarboxylated to dopamine, Danio rerio"
xref: Reactome:REACT_40024 "Dopa is decarboxylated to dopamine, Gallus gallus"
xref: Reactome:REACT_77761 "Dopa is decarboxylated to dopamine, Xenopus tropicalis"
xref: Reactome:REACT_78186 "Dopa is decarboxylated to dopamine, Canis familiaris"
xref: Reactome:REACT_82232 "Dopa is decarboxylated to dopamine, Rattus norvegicus"
xref: Reactome:REACT_85510 "Decarboxylation of 5-hydroxytryptophan forms serotonin, Arabidopsis thaliana"
xref: Reactome:REACT_87158 "Decarboxylation of 5-hydroxytryptophan forms serotonin, Mus musculus"
xref: Reactome:REACT_92081 "Decarboxylation of 5-hydroxytryptophan forms serotonin, Danio rerio"
xref: Reactome:REACT_93251 "Dopa is decarboxylated to dopamine, Bos taurus"
xref: Reactome:REACT_96152 "Dopa is decarboxylated to dopamine, Oryza sativa"
xref: Reactome:REACT_96639 "Decarboxylation of 5-hydroxytryptophan forms serotonin, Oryza sativa"
xref: Reactome:REACT_97213 "Dopa is decarboxylated to dopamine, Mus musculus"
xref: Reactome:REACT_97677 "Decarboxylation of 5-hydroxytryptophan forms serotonin, Gallus gallus"
xref: Reactome:REACT_99387 "Dopa is decarboxylated to dopamine, Drosophila melanogaster"
xref: Reactome:REACT_99826 "Dopa is decarboxylated to dopamine, Sus scrofa"
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004059
name: aralkylamine N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + an aralkylamine = CoA + an N-acetylaralkylamine." [EC:2.3.1.87]
synonym: "AANAT activity" EXACT [EC:2.3.1.87]
synonym: "acetyl-CoA:2-arylethylamine N-acetyltransferase activity" EXACT [EC:2.3.1.87]
synonym: "arylalkylamine N-acetyltransferase activity" EXACT [EC:2.3.1.87]
synonym: "melatonin rhythm enzyme activity" RELATED [EC:2.3.1.87]
synonym: "serotonin acetylase activity" NARROW [EC:2.3.1.87]
synonym: "serotonin acetyltransferase activity" NARROW [EC:2.3.1.87]
synonym: "serotonin N-acetyltransferase activity" NARROW [EC:2.3.1.87]
xref: EC:2.3.1.87
xref: MetaCyc:ARALKYLAMINE-N-ACETYLTRANSFERASE-RXN
xref: Reactome:REACT_102250 "N-acetylation of serotonin, Rattus norvegicus"
xref: Reactome:REACT_102805 "N-acetylation of serotonin, Gallus gallus"
xref: Reactome:REACT_104511 "N-acetylation of serotonin, Xenopus tropicalis"
xref: Reactome:REACT_15290 "N-acetylation of serotonin, Homo sapiens"
xref: Reactome:REACT_29536 "N-acetylation of serotonin, Mus musculus"
xref: Reactome:REACT_33625 "N-acetylation of serotonin, Canis familiaris"
xref: Reactome:REACT_81480 "N-acetylation of serotonin, Danio rerio"
xref: Reactome:REACT_85448 "N-acetylation of serotonin, Taeniopygia guttata"
xref: Reactome:REACT_86020 "N-acetylation of serotonin, Sus scrofa"
xref: Reactome:REACT_92297 "N-acetylation of serotonin, Bos taurus"
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0004060
name: arylamine N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + an arylamine = CoA + an N-acetylarylamine." [EC:2.3.1.5]
subset: gosubset_prok
synonym: "2-naphthylamine N-acetyltransferase activity" EXACT [EC:2.3.1.5]
synonym: "4-aminobiphenyl N-acetyltransferase activity" EXACT [EC:2.3.1.5]
synonym: "acetyl CoA-arylamine N-acetyltransferase activity" EXACT [EC:2.3.1.5]
synonym: "acetyl-CoA:arylamine N-acetyltransferase activity" EXACT [EC:2.3.1.5]
synonym: "arylamine acetylase activity" EXACT [EC:2.3.1.5]
synonym: "arylamine acetyltransferase activity" EXACT [EC:2.3.1.5]
synonym: "beta-naphthylamine N-acetyltransferase activity" EXACT [EC:2.3.1.5]
synonym: "indoleamine N-acetyltransferase activity" EXACT [EC:2.3.1.5]
synonym: "p-aminosalicylate N-acetyltransferase activity" EXACT [EC:2.3.1.5]
xref: EC:2.3.1.5
xref: MetaCyc:ARYLAMINE-N-ACETYLTRANSFERASE-RXN
xref: Reactome:REACT_104415 "NAT2 acetylation, Sus scrofa"
xref: Reactome:REACT_105583 "NAT2 acetylation, Taeniopygia guttata"
xref: Reactome:REACT_108176 "NAT1 acetylation, Sus scrofa"
xref: Reactome:REACT_113266 "NAT1 acetylation, Staphylococcus aureus N315"
xref: Reactome:REACT_115264 "NAT2 acetylation, Staphylococcus aureus N315"
xref: Reactome:REACT_28496 "NAT2 acetylation, Danio rerio"
xref: Reactome:REACT_29504 "NAT2 acetylation, Mycobacterium tuberculosis"
xref: Reactome:REACT_32809 "NAT2 acetylation, Escherichia coli"
xref: Reactome:REACT_33982 "NAT1 acetylation, Gallus gallus"
xref: Reactome:REACT_6832 "NAT1 acetylation, Homo sapiens"
xref: Reactome:REACT_6944 "NAT2 acetylation, Homo sapiens"
xref: Reactome:REACT_82229 "NAT1 acetylation, Escherichia coli"
xref: Reactome:REACT_83190 "NAT2 acetylation, Bos taurus"
xref: Reactome:REACT_83509 "NAT2 acetylation, Rattus norvegicus"
xref: Reactome:REACT_83772 "NAT1 acetylation, Rattus norvegicus"
xref: Reactome:REACT_84287 "NAT1 acetylation, Bos taurus"
xref: Reactome:REACT_85456 "NAT2 acetylation, Mus musculus"
xref: Reactome:REACT_85532 "NAT1 acetylation, Danio rerio"
xref: Reactome:REACT_88074 "NAT1 acetylation, Mus musculus"
xref: Reactome:REACT_91678 "NAT2 acetylation, Gallus gallus"
xref: Reactome:REACT_91780 "NAT1 acetylation, Mycobacterium tuberculosis"
xref: Reactome:REACT_99622 "NAT1 acetylation, Taeniopygia guttata"
xref: UM-BBD_enzymeID:e0341
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0004061
name: arylformamidase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-formyl-L-kynurenine + H2O = formate + L-kynurenine." [EC:3.5.1.9]
subset: gosubset_prok
synonym: "aryl-formylamine amidohydrolase activity" EXACT [EC:3.5.1.9]
synonym: "formamidase I" RELATED [EC:3.5.1.9]
synonym: "formamidase II" RELATED [EC:3.5.1.9]
synonym: "formylase activity" EXACT [EC:3.5.1.9]
synonym: "formylkynureninase activity" EXACT [EC:3.5.1.9]
synonym: "formylkynurenine formamidase activity" EXACT [EC:3.5.1.9]
synonym: "kynurenine formamidase activity" EXACT [EC:3.5.1.9]
xref: EC:3.5.1.9
xref: MetaCyc:ARYLFORMAMIDASE-RXN
xref: Reactome:REACT_101177 "N-formylkynurenine + H2O => kynurenine + formate, Danio rerio"
xref: Reactome:REACT_101720 "N-formylkynurenine + H2O => kynurenine + formate, Drosophila melanogaster"
xref: Reactome:REACT_105730 "N-formylkynurenine + H2O => kynurenine + formate, Xenopus tropicalis"
xref: Reactome:REACT_106733 "N-formylkynurenine + H2O => kynurenine + formate, Taeniopygia guttata"
xref: Reactome:REACT_110747 "N-formylkynurenine + H2O => kynurenine + formate, Bos taurus"
xref: Reactome:REACT_1187 "N-formylkynurenine + H2O => kynurenine + formate [mouse], Mus musculus"
xref: Reactome:REACT_1804 "N-formylkynurenine + H2O => kynurenine + formate, Homo sapiens"
xref: Reactome:REACT_31432 "N-formylkynurenine + H2O => kynurenine + formate, Gallus gallus"
xref: Reactome:REACT_46660 "N-formylkynurenine + H2O => kynurenine + formate, Caenorhabditis elegans"
xref: Reactome:REACT_97680 "N-formylkynurenine + H2O => kynurenine + formate, Canis familiaris"
xref: RHEA:13012
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0004062
name: aryl sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate." [EC:2.8.2.1]
subset: goslim_chembl
subset: gosubset_prok
synonym: "1-naphthol phenol sulfotransferase activity" EXACT [EC:2.8.2.1]
synonym: "2-naphtholsulfotransferase activity" EXACT [EC:2.8.2.1]
synonym: "3'-phosphoadenylyl-sulfate:phenol sulfotransferase activity" EXACT [EC:2.8.2.1]
synonym: "4-nitrocatechol sulfokinase activity" EXACT [EC:2.8.2.1]
synonym: "aryl sulphotransferase activity" EXACT []
synonym: "arylsulfotransferase" BROAD [EC:2.8.2.1]
synonym: "dopamine sulfotransferase activity" EXACT [EC:2.8.2.1]
synonym: "p-nitrophenol sulfotransferase activity" EXACT [EC:2.8.2.1]
synonym: "phenol sulfokinase activity" EXACT [EC:2.8.2.1]
synonym: "phenol sulfotransferase activity" EXACT [EC:2.8.2.1]
synonym: "PST" RELATED [EC:2.8.2.1]
synonym: "ritodrine sulfotransferase activity" EXACT [EC:2.8.2.1]
synonym: "sulfokinase activity" RELATED [EC:2.8.2.1]
xref: EC:2.8.2.1
xref: MetaCyc:ARYL-SULFOTRANSFERASE-RXN
xref: Reactome:REACT_101593 "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP, Drosophila melanogaster"
xref: Reactome:REACT_101626 "Acetaminophen can form an O- sulfate conjugate, Xenopus tropicalis"
xref: Reactome:REACT_103168 "N-hydroxy-4-aminobiphenyl can form a sulfate conjugate, Bos taurus"
xref: Reactome:REACT_103360 "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP, Danio rerio"
xref: Reactome:REACT_103392 "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP, Gallus gallus"
xref: Reactome:REACT_103811 "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP, Xenopus tropicalis"
xref: Reactome:REACT_104618 "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP, Bos taurus"
xref: Reactome:REACT_105302 "N-hydroxy-4-aminobiphenyl can form a sulfate conjugate, Xenopus tropicalis"
xref: Reactome:REACT_105483 "Phenol can form a sulfate conjugate, Mus musculus"
xref: Reactome:REACT_106988 "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP, Bos taurus"
xref: Reactome:REACT_107852 "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP, Gallus gallus"
xref: Reactome:REACT_109219 "Phenol can form a sulfate conjugate, Canis familiaris"
xref: Reactome:REACT_112861 "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP, Rattus norvegicus"
xref: Reactome:REACT_113420 "Dopamine can form an O-sulfate conjugate, Danio rerio"
xref: Reactome:REACT_113755 "Acetaminophen can form an O- sulfate conjugate, Rattus norvegicus"
xref: Reactome:REACT_113826 "Acetaminophen can form an O- sulfate conjugate, Danio rerio"
xref: Reactome:REACT_114350 "Phenol can form a sulfate conjugate, Rattus norvegicus"
xref: Reactome:REACT_114511 "Phenol can form a sulfate conjugate, Danio rerio"
xref: Reactome:REACT_114894 "N-hydroxy-4-aminobiphenyl can form a sulfate conjugate, Danio rerio"
xref: Reactome:REACT_115246 "N-hydroxy-4-aminobiphenyl can form a sulfate conjugate, Rattus norvegicus"
xref: Reactome:REACT_115272 "Dopamine can form an O-sulfate conjugate, Rattus norvegicus"
xref: Reactome:REACT_28338 "Acetaminophen can form an O- sulfate conjugate, Canis familiaris"
xref: Reactome:REACT_28779 "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP, Mus musculus"
xref: Reactome:REACT_30659 "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP, Xenopus tropicalis"
xref: Reactome:REACT_31265 "N-hydroxy-4-aminobiphenyl can form a sulfate conjugate, Canis familiaris"
xref: Reactome:REACT_31366 "Phenol can form a sulfate conjugate, Xenopus tropicalis"
xref: Reactome:REACT_32021 "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP, Bos taurus"
xref: Reactome:REACT_32963 "Dopamine can form an O-sulfate conjugate, Canis familiaris"
xref: Reactome:REACT_33894 "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP, Xenopus tropicalis"
xref: Reactome:REACT_34807 "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP, Danio rerio"
xref: Reactome:REACT_6722 "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP, Homo sapiens"
xref: Reactome:REACT_6740 "Dopamine can form an O-sulfate conjugate, Homo sapiens"
xref: Reactome:REACT_6765 "Acetaminophen can form an O- sulfate conjugate, Homo sapiens"
xref: Reactome:REACT_6855 "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP, Homo sapiens"
xref: Reactome:REACT_6868 "N-hydroxy-4-aminobiphenyl can form a sulfate conjugate, Homo sapiens"
xref: Reactome:REACT_6897 "Phenol can form a sulfate conjugate, Homo sapiens"
xref: Reactome:REACT_6961 "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP, Homo sapiens"
xref: Reactome:REACT_77729 "Dopamine can form an O-sulfate conjugate, Xenopus tropicalis"
xref: Reactome:REACT_78668 "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP, Canis familiaris"
xref: Reactome:REACT_80310 "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP, Canis familiaris"
xref: Reactome:REACT_80654 "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP, Mus musculus"
xref: Reactome:REACT_80880 "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP, Sus scrofa"
xref: Reactome:REACT_81976 "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP, Rattus norvegicus"
xref: Reactome:REACT_83825 "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP, Mus musculus"
xref: Reactome:REACT_83936 "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP, Taeniopygia guttata"
xref: Reactome:REACT_84713 "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP, Taeniopygia guttata"
xref: Reactome:REACT_87537 "Acetaminophen can form an O- sulfate conjugate, Bos taurus"
xref: Reactome:REACT_88863 "N-hydroxy-4-aminobiphenyl can form a sulfate conjugate, Mus musculus"
xref: Reactome:REACT_89258 "Dopamine can form an O-sulfate conjugate, Mus musculus"
xref: Reactome:REACT_89426 "Dopamine can form an O-sulfate conjugate, Bos taurus"
xref: Reactome:REACT_90170 "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP, Rattus norvegicus"
xref: Reactome:REACT_90269 "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP, Danio rerio"
xref: Reactome:REACT_90981 "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP, Gallus gallus"
xref: Reactome:REACT_91386 "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP, Sus scrofa"
xref: Reactome:REACT_91525 "Acetaminophen can form an O- sulfate conjugate, Mus musculus"
xref: Reactome:REACT_91946 "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP, Taeniopygia guttata"
xref: Reactome:REACT_92808 "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP, Canis familiaris"
xref: Reactome:REACT_94928 "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP, Drosophila melanogaster"
xref: Reactome:REACT_95232 "Phenol can form a sulfate conjugate, Bos taurus"
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0004063
name: aryldialkylphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol." [EC:3.1.8.1]
subset: gosubset_prok
synonym: "A-esterase activity" BROAD [EC:3.1.8.1]
synonym: "aryltriphosphatase activity" EXACT [EC:3.1.8.1]
synonym: "aryltriphosphate dialkylphosphohydrolase activity" EXACT [EC:3.1.8.1]
synonym: "esterase B1" RELATED [EC:3.1.8.1]
synonym: "esterase E4" RELATED [EC:3.1.8.1]
synonym: "OPH" RELATED [EC:3.1.8.1]
synonym: "organophosphate esterase activity" EXACT [EC:3.1.8.1]
synonym: "organophosphate hydrolase activity" EXACT [EC:3.1.8.1]
synonym: "organophosphorus acid anhydrase activity" EXACT [EC:3.1.8.1]
synonym: "organophosphorus hydrolase activity" EXACT [EC:3.1.8.1]
synonym: "paraoxon esterase activity" EXACT [EC:3.1.8.1]
synonym: "paraoxon hydrolase activity" BROAD [EC:3.1.8.1]
synonym: "paraoxonase activity" BROAD [EC:3.1.8.1]
synonym: "phosphotriesterase activity" EXACT [EC:3.1.8.1]
synonym: "pirimiphos-methyloxon esterase activity" EXACT [EC:3.1.8.1]
xref: EC:3.1.8.1
xref: MetaCyc:ARYLDIALKYLPHOSPHATASE-RXN
xref: UM-BBD_enzymeID:e0054
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0004064
name: arylesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: a phenyl acetate + H2O = a phenol + acetate." [EC:3.1.1.2]
subset: gosubset_prok
synonym: "A-esterase activity" BROAD [EC:3.1.1.2]
synonym: "aromatic esterase" NARROW [EC:3.1.1.2]
synonym: "aryl-ester hydrolase" NARROW [EC:3.1.1.2]
synonym: "paraoxonase activity" BROAD [EC:3.1.1.2]
xref: EC:3.1.1.2
xref: MetaCyc:ARYLESTERASE-RXN
xref: UM-BBD_reactionID:r0757
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0004065
name: arylsulfatase activity
namespace: molecular_function
def: "Catalysis of the reaction: a phenol sulfate + H2O = a phenol + sulfate." [EC:3.1.6.1]
subset: gosubset_prok
synonym: "4-methylumbelliferyl sulfatase activity" EXACT [EC:3.1.6.1]
synonym: "aryl-sulfate sulfohydrolase activity" EXACT [EC:3.1.6.1]
synonym: "aryl-sulfate sulphohydrolase activity" EXACT [EC:3.1.6.1]
synonym: "aryl-sulphate sulphohydrolase activity" EXACT [EC:3.1.6.1]
synonym: "arylsulfohydrolase activity" EXACT [EC:3.1.6.1]
synonym: "arylsulphatase activity" EXACT []
synonym: "estrogen sulfatase activity" EXACT [EC:3.1.6.1]
synonym: "nitrocatechol sulfatase activity" EXACT [EC:3.1.6.1]
synonym: "p-nitrophenyl sulfatase activity" EXACT [EC:3.1.6.1]
synonym: "phenolsulfatase activity" EXACT [EC:3.1.6.1]
synonym: "phenylsulfatase activity" EXACT [EC:3.1.6.1]
synonym: "sulfatase activity" RELATED [EC:3.1.6.1]
xref: EC:3.1.6.1
xref: MetaCyc:ARYLSULFAT-RXN
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0004066
name: asparagine synthase (glutamine-hydrolyzing) activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate." [EC:6.3.5.4]
subset: gosubset_prok
synonym: "AS" RELATED [EC:6.3.5.4]
synonym: "AS-B activity" EXACT [EC:6.3.5.4]
synonym: "asparagine synthase (glutamine-hydrolysing)" EXACT [EC:6.3.5.4]
synonym: "asparagine synthetase (glutamine-hydrolysing)" EXACT [EC:6.3.5.4]
synonym: "asparagine synthetase (glutamine-hydrolyzing) activity" EXACT [EC:6.3.5.4]
synonym: "asparagine synthetase B activity" EXACT [EC:6.3.5.4]
synonym: "glutamine-dependent asparagine synthetase activity" EXACT [EC:6.3.5.4]
synonym: "L-aspartate:L-glutamine amido-ligase (AMP-forming)" EXACT [EC:6.3.5.4]
xref: EC:6.3.5.4
xref: MetaCyc:ASNSYNB-RXN
xref: Reactome:REACT_102336 "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS], Schizosaccharomyces pombe"
xref: Reactome:REACT_107530 "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS], Escherichia coli"
xref: Reactome:REACT_109835 "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS], Mus musculus"
xref: Reactome:REACT_112740 "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS], Oryza sativa"
xref: Reactome:REACT_113607 "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS], Arabidopsis thaliana"
xref: Reactome:REACT_114769 "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS], Saccharomyces cerevisiae"
xref: Reactome:REACT_277 "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS], Homo sapiens"
xref: Reactome:REACT_30477 "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS], Rattus norvegicus"
xref: Reactome:REACT_31824 "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS], Mycobacterium tuberculosis"
xref: Reactome:REACT_31879 "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS], Drosophila melanogaster"
xref: Reactome:REACT_34512 "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS], Canis familiaris"
xref: Reactome:REACT_80145 "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS], Plasmodium falciparum"
xref: Reactome:REACT_80719 "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS], Xenopus tropicalis"
xref: Reactome:REACT_81036 "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS], Dictyostelium discoideum"
xref: Reactome:REACT_86665 "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS], Caenorhabditis elegans"
xref: Reactome:REACT_86705 "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS], Bos taurus"
xref: Reactome:REACT_91813 "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS], Sus scrofa"
xref: Reactome:REACT_94577 "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS], Taeniopygia guttata"
xref: Reactome:REACT_95520 "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS], Gallus gallus"
xref: Reactome:REACT_97491 "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS], Danio rerio"
xref: RHEA:24877
is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor

[Term]
id: GO:0004067
name: asparaginase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3." [EC:3.5.1.1]
subset: gosubset_prok
synonym: "alpha-asparaginase activity" EXACT [EC:3.5.1.1]
synonym: "asparaginase II" RELATED [EC:3.5.1.1]
synonym: "colaspase activity" EXACT [EC:3.5.1.1]
synonym: "crasnitin" RELATED [EC:3.5.1.1]
synonym: "elspar" RELATED [EC:3.5.1.1]
synonym: "L-asparaginase activity" EXACT [EC:3.5.1.1]
synonym: "L-asparagine amidohydrolase activity" EXACT [EC:3.5.1.1]
synonym: "leunase activity" EXACT [EC:3.5.1.1]
xref: EC:3.5.1.1
xref: MetaCyc:ASPARAGHYD-RXN
xref: RHEA:21019
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0004068
name: aspartate 1-decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-aspartate = beta-alanine + CO2." [EC:4.1.1.11]
subset: gosubset_prok
synonym: "aspartate alpha-decarboxylase activity" EXACT [EC:4.1.1.11]
synonym: "aspartic alpha-decarboxylase" BROAD [EC:4.1.1.11]
synonym: "L-aspartate 1-carboxy-lyase (beta-alanine-forming)" EXACT [EC:4.1.1.11]
synonym: "L-aspartate 1-carboxy-lyase activity" EXACT [EC:4.1.1.11]
synonym: "L-aspartate alpha-decarboxylase activity" EXACT [EC:4.1.1.11]
xref: EC:4.1.1.11
xref: MetaCyc:ASPDECARBOX-RXN
xref: MetaCyc:PWY-5155
xref: RHEA:19500
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004069
name: L-aspartate:2-oxoglutarate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate." [EC:2.6.1.1]
subset: gosubset_prok
synonym: "2-oxoglutarate-glutamate aminotransferase activity" EXACT [EC:2.6.1.1]
synonym: "AAT" RELATED [EC:2.6.1.1]
synonym: "aspartate alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.1]
synonym: "aspartate aminotransferase activity" BROAD []
synonym: "aspartate transaminase activity" BROAD [EC:2.6.1.1]
synonym: "aspartate-2-oxoglutarate transaminase activity" EXACT [EC:2.6.1.1]
synonym: "aspartate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.1]
synonym: "aspartic acid aminotransferase activity" BROAD [EC:2.6.1.1]
synonym: "aspartic aminotransferase activity" BROAD [EC:2.6.1.1]
synonym: "aspartyl aminotransferase activity" BROAD [EC:2.6.1.1]
synonym: "AspT" RELATED [EC:2.6.1.1]
synonym: "glutamate oxaloacetate transaminase activity" EXACT [EC:2.6.1.1]
synonym: "glutamate-oxalacetate aminotransferase activity" EXACT [EC:2.6.1.1]
synonym: "glutamate-oxalate transaminase activity" EXACT [EC:2.6.1.1]
synonym: "glutamic oxalic transaminase activity" EXACT [EC:2.6.1.1]
synonym: "glutamic--aspartic transaminase activity" EXACT [EC:2.6.1.1]
synonym: "glutamic--oxaloacetic transaminase activity" EXACT [EC:2.6.1.1]
synonym: "glutamic-aspartic aminotransferase activity" EXACT [EC:2.6.1.1]
synonym: "glutamic-oxalacetic transaminase activity" EXACT [EC:2.6.1.1]
synonym: "GOT (enzyme)" RELATED [EC:2.6.1.1]
synonym: "L-aspartate transaminase activity" BROAD [EC:2.6.1.1]
synonym: "L-aspartate-2-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.1]
synonym: "L-aspartate-2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.1]
synonym: "L-aspartate-2-oxoglutarate-transaminase activity" EXACT [EC:2.6.1.1]
synonym: "L-aspartate-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.1]
synonym: "L-aspartic aminotransferase activity" BROAD [EC:2.6.1.1]
synonym: "oxaloacetate transferase activity" EXACT [EC:2.6.1.1]
synonym: "oxaloacetate-aspartate aminotransferase activity" EXACT [EC:2.6.1.1]
synonym: "transaminase A activity" RELATED [EC:2.6.1.1]
xref: EC:2.6.1.1
xref: KEGG:R00355
xref: MetaCyc:ASPAMINOTRANS-RXN
xref: Reactome:REACT_100250 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1], Rattus norvegicus"
xref: Reactome:REACT_100619 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2], Mus musculus"
xref: Reactome:REACT_101098 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1], Gallus gallus"
xref: Reactome:REACT_102229 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT2], Bos taurus"
xref: Reactome:REACT_102338 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2], Bos taurus"
xref: Reactome:REACT_104061 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT2], Canis familiaris"
xref: Reactome:REACT_104242 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1], Sus scrofa"
xref: Reactome:REACT_104365 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT2], Dictyostelium discoideum"
xref: Reactome:REACT_104429 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT2], Drosophila melanogaster"
xref: Reactome:REACT_105965 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1], Schizosaccharomyces pombe"
xref: Reactome:REACT_106583 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1], Escherichia coli"
xref: Reactome:REACT_107401 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT2], Oryza sativa"
xref: Reactome:REACT_107422 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT2], Taeniopygia guttata"
xref: Reactome:REACT_107443 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1], Canis familiaris"
xref: Reactome:REACT_107885 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1], Oryza sativa"
xref: Reactome:REACT_108823 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1], Mus musculus"
xref: Reactome:REACT_109829 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1], Sus scrofa"
xref: Reactome:REACT_110632 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2], Gallus gallus"
xref: Reactome:REACT_110701 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1], Taeniopygia guttata"
xref: Reactome:REACT_112410 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1], Plasmodium falciparum"
xref: Reactome:REACT_112542 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2], Plasmodium falciparum"
xref: Reactome:REACT_113079 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1], Plasmodium falciparum"
xref: Reactome:REACT_115016 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2], Rattus norvegicus"
xref: Reactome:REACT_115018 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT2], Rattus norvegicus"
xref: Reactome:REACT_115062 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT2], Plasmodium falciparum"
xref: Reactome:REACT_115765 "aspartate + alpha-ketoglutarate (2-oxoglutarate) <=> oxaloacetate + glutamate, Gallus gallus"
xref: Reactome:REACT_115783 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate (2-oxoglutarate), Gallus gallus"
xref: Reactome:REACT_115863 "aspartate + alpha-ketoglutarate (2-oxoglutarate) <=> oxaloacetate + glutamate, Gallus gallus"
xref: Reactome:REACT_115958 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate (2-oxoglutarate), Gallus gallus"
xref: Reactome:REACT_1558 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1], Homo sapiens"
xref: Reactome:REACT_1632 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2], Homo sapiens"
xref: Reactome:REACT_2078 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1], Homo sapiens"
xref: Reactome:REACT_280 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT2], Homo sapiens"
xref: Reactome:REACT_28947 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1], Taeniopygia guttata"
xref: Reactome:REACT_28965 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT2], Sus scrofa"
xref: Reactome:REACT_31038 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT2], Caenorhabditis elegans"
xref: Reactome:REACT_31146 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2], Canis familiaris"
xref: Reactome:REACT_32675 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2], Drosophila melanogaster"
xref: Reactome:REACT_34387 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1], Danio rerio"
xref: Reactome:REACT_34754 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1], Dictyostelium discoideum"
xref: Reactome:REACT_67549 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT2], Schizosaccharomyces pombe"
xref: Reactome:REACT_77562 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1], Dictyostelium discoideum"
xref: Reactome:REACT_77740 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2], Arabidopsis thaliana"
xref: Reactome:REACT_79228 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1], Drosophila melanogaster"
xref: Reactome:REACT_80018 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1], Arabidopsis thaliana"
xref: Reactome:REACT_80569 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1], Caenorhabditis elegans"
xref: Reactome:REACT_80879 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT2], Xenopus tropicalis"
xref: Reactome:REACT_82087 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1], Gallus gallus"
xref: Reactome:REACT_82808 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1], Escherichia coli"
xref: Reactome:REACT_82944 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT2], Danio rerio"
xref: Reactome:REACT_83266 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2], Escherichia coli"
xref: Reactome:REACT_84706 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1], Bos taurus"
xref: Reactome:REACT_84867 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1], Canis familiaris"
xref: Reactome:REACT_85085 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1], Bos taurus"
xref: Reactome:REACT_86159 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1], Xenopus tropicalis"
xref: Reactome:REACT_86367 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2], Taeniopygia guttata"
xref: Reactome:REACT_87626 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1], Arabidopsis thaliana"
xref: Reactome:REACT_89219 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1], Oryza sativa"
xref: Reactome:REACT_89337 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT2], Mus musculus"
xref: Reactome:REACT_89398 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT2], Arabidopsis thaliana"
xref: Reactome:REACT_89436 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1], Drosophila melanogaster"
xref: Reactome:REACT_90427 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT2], Gallus gallus"
xref: Reactome:REACT_91145 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2], Sus scrofa"
xref: Reactome:REACT_91482 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1], Mus musculus"
xref: Reactome:REACT_91798 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2], Xenopus tropicalis"
xref: Reactome:REACT_92155 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2], Oryza sativa"
xref: Reactome:REACT_92692 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2], Dictyostelium discoideum"
xref: Reactome:REACT_93130 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2], Caenorhabditis elegans"
xref: Reactome:REACT_93870 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT2], Escherichia coli"
xref: Reactome:REACT_94071 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2], Schizosaccharomyces pombe"
xref: Reactome:REACT_94790 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1], Schizosaccharomyces pombe"
xref: Reactome:REACT_95383 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2], Danio rerio"
xref: Reactome:REACT_95640 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1], Caenorhabditis elegans"
xref: Reactome:REACT_95714 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1], Xenopus tropicalis"
xref: Reactome:REACT_96608 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1], Saccharomyces cerevisiae"
xref: Reactome:REACT_98136 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1], Rattus norvegicus"
xref: Reactome:REACT_98564 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1], Saccharomyces cerevisiae"
xref: Reactome:REACT_99695 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1], Danio rerio"
xref: RHEA:21827
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0004070
name: aspartate carbamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + H(+) + phosphate." [EC:2.1.3.2, RHEA:20016]
subset: gosubset_prok
synonym: "aspartate carbamyltransferase activity" EXACT [EC:2.1.3.2]
synonym: "aspartate transcarbamoylase activity" EXACT [EC:2.1.3.2]
synonym: "aspartate transcarbamylase activity" EXACT [EC:2.1.3.2]
synonym: "aspartic acid transcarbamoylase activity" EXACT [EC:2.1.3.2]
synonym: "aspartic carbamyltransferase activity" EXACT [EC:2.1.3.2]
synonym: "aspartic transcarbamylase activity" EXACT [EC:2.1.3.2]
synonym: "ATCase activity" EXACT [EC:2.1.3.2]
synonym: "carbamoyl-phosphate:L-aspartate carbamoyltransferase activity" EXACT [EC:2.1.3.2]
synonym: "carbamoylaspartotranskinase activity" EXACT [EC:2.1.3.2]
synonym: "carbamylaspartotranskinase activity" EXACT [EC:2.1.3.2]
synonym: "L-aspartate transcarbamoylase activity" EXACT [EC:2.1.3.2]
synonym: "L-aspartate transcarbamylase activity" EXACT [EC:2.1.3.2]
xref: EC:2.1.3.2
xref: KEGG:R01397
xref: MetaCyc:ASPCARBTRANS-RXN
xref: Reactome:REACT_103105 "carbamoyl phosphate + L-aspartate <=> N-carbamoyl L-aspartate + orthophosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_105018 "carbamoyl phosphate + L-aspartate <=> N-carbamoyl L-aspartate + orthophosphate, Taeniopygia guttata"
xref: Reactome:REACT_107363 "carbamoyl phosphate + L-aspartate <=> N-carbamoyl L-aspartate + orthophosphate, Staphylococcus aureus N315"
xref: Reactome:REACT_110200 "carbamoyl phosphate + L-aspartate <=> N-carbamoyl L-aspartate + orthophosphate, Plasmodium falciparum"
xref: Reactome:REACT_115976 "carbamoyl phosphate + L-aspartate <=> N-carbamoyl L-aspartate + orthophosphate, Gallus gallus"
xref: Reactome:REACT_1965 "carbamoyl phosphate + L-aspartate <=> N-carbamoyl L-aspartate + orthophosphate, Homo sapiens"
xref: Reactome:REACT_30409 "carbamoyl phosphate + L-aspartate <=> N-carbamoyl L-aspartate + orthophosphate, Bos taurus"
xref: Reactome:REACT_30529 "carbamoyl phosphate + L-aspartate <=> N-carbamoyl L-aspartate + orthophosphate, Canis familiaris"
xref: Reactome:REACT_80965 "carbamoyl phosphate + L-aspartate <=> N-carbamoyl L-aspartate + orthophosphate, Rattus norvegicus"
xref: Reactome:REACT_89217 "carbamoyl phosphate + L-aspartate <=> N-carbamoyl L-aspartate + orthophosphate, Danio rerio"
xref: Reactome:REACT_90716 "carbamoyl phosphate + L-aspartate <=> N-carbamoyl L-aspartate + orthophosphate, Mus musculus"
xref: Reactome:REACT_91724 "carbamoyl phosphate + L-aspartate <=> N-carbamoyl L-aspartate + orthophosphate, Caenorhabditis elegans"
xref: Reactome:REACT_96047 "carbamoyl phosphate + L-aspartate <=> N-carbamoyl L-aspartate + orthophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_98356 "carbamoyl phosphate + L-aspartate <=> N-carbamoyl L-aspartate + orthophosphate, Drosophila melanogaster"
xref: Reactome:REACT_98452 "carbamoyl phosphate + L-aspartate <=> N-carbamoyl L-aspartate + orthophosphate, Saccharomyces cerevisiae"
xref: RHEA:20016
is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity

[Term]
id: GO:0004071
name: aspartate-ammonia ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-aspartate + NH3 = AMP + diphosphate + L-asparagine." [EC:6.3.1.1]
subset: gosubset_prok
synonym: "asparagine synthetase activity" EXACT [EC:6.3.1.1]
synonym: "L-asparagine synthetase activity" EXACT [EC:6.3.1.1]
synonym: "L-aspartate:ammonia ligase (AMP-forming)" EXACT [EC:6.3.1.1]
xref: EC:6.3.1.1
xref: MetaCyc:ASNSYNA-RXN
xref: RHEA:11375
is_a: GO:0016211 ! ammonia ligase activity

[Term]
id: GO:0004072
name: aspartate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-aspartate + ATP = 4-phospho-L-aspartate + ADP + H(+)." [EC:2.7.2.4, RHEA:23779]
subset: gosubset_prok
synonym: "aspartic kinase activity" EXACT [EC:2.7.2.4]
synonym: "aspartokinase activity" EXACT [EC:2.7.2.4]
synonym: "ATP:L-aspartate 4-phosphotransferase activity" EXACT [EC:2.7.2.4]
synonym: "beta-aspartokinase activity" EXACT [EC:2.7.2.4]
xref: EC:2.7.2.4
xref: KEGG:R00480
xref: MetaCyc:ASPARTATEKIN-RXN
xref: RHEA:23779
is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor
is_a: GO:0019202 ! amino acid kinase activity

[Term]
id: GO:0004073
name: aspartate-semialdehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH." [EC:1.2.1.11, RHEA:24287]
subset: gosubset_prok
synonym: "ASA dehydrogenase activity" EXACT [EC:1.2.1.11]
synonym: "aspartate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.11]
synonym: "aspartic beta-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.11]
synonym: "aspartic semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.11]
synonym: "L-aspartate-4-semialdehyde:NADP+ oxidoreductase (phosphorylating)" EXACT [EC:1.2.1.11]
synonym: "L-aspartate-beta-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.11]
synonym: "L-aspartate-beta-semialdehyde:NADP oxidoreductase (phosporylating)" EXACT [EC:1.2.1.11]
xref: EC:1.2.1.11
xref: KEGG:R02291
xref: MetaCyc:ASPARTATE-SEMIALDEHYDE-DEHYDROGENASE-RXN
xref: RHEA:24287
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004074
name: biliverdin reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: bilirubin + NAD(P)+ = biliverdin + NAD(P)H + H+." [EC:1.3.1.24]
synonym: "bilirubin:NAD(P)+ oxidoreductase activity" EXACT [EC:1.3.1.24]
xref: EC:1.3.1.24
xref: MetaCyc:BILIVERDIN-REDUCTASE-RXN
xref: Reactome:REACT_22177 "Biliverdin is reduced to bilirubin, Homo sapiens"
xref: Reactome:REACT_31500 "Biliverdin is reduced to bilirubin, Mus musculus"
xref: Reactome:REACT_32959 "Biliverdin is reduced to bilirubin, Danio rerio"
xref: Reactome:REACT_34270 "Biliverdin is reduced to bilirubin, Gallus gallus"
xref: Reactome:REACT_81350 "Biliverdin is reduced to bilirubin, Drosophila melanogaster"
xref: Reactome:REACT_82319 "Biliverdin is reduced to bilirubin, Bos taurus"
xref: Reactome:REACT_88875 "Biliverdin is reduced to bilirubin, Taeniopygia guttata"
xref: Reactome:REACT_89833 "Biliverdin is reduced to bilirubin, Rattus norvegicus"
xref: Reactome:REACT_91067 "Biliverdin is reduced to bilirubin, Xenopus tropicalis"
xref: Reactome:REACT_91178 "Biliverdin is reduced to bilirubin, Sus scrofa"
xref: Reactome:REACT_93458 "Biliverdin is reduced to bilirubin, Canis familiaris"
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004075
name: biotin carboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein." [EC:6.3.4.14]
subset: gosubset_prok
synonym: "biotin carboxylase (component of acetyl CoA carboxylase) activity" EXACT [EC:6.3.4.14]
synonym: "biotin-carboxyl-carrier-protein:carbon-dioxide ligase (ADP-forming) activity" EXACT [EC:6.3.4.14]
xref: EC:6.3.4.14
xref: MetaCyc:BIOTIN-CARBOXYL-RXN
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0004076
name: biotin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + dethiobiotin + S(2-) = 2 5'-deoxyadenosine + 2 L-methionine + biotin + H(+)." [EC:2.8.1.6, RHEA:22063]
subset: gosubset_prok
synonym: "biotin synthetase activity" EXACT [EC:2.8.1.6]
synonym: "dethiobiotin:sulfur sulfurtransferase activity" EXACT [EC:2.8.1.6]
xref: EC:2.8.1.6
xref: KEGG:R01078
xref: MetaCyc:2.8.1.6-RXN
xref: RHEA:22063
is_a: GO:0016783 ! sulfurtransferase activity
is_a: GO:0070283 ! radical SAM enzyme activity

[Term]
id: GO:0004077
name: biotin-[acetyl-CoA-carboxylase] ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + biotin + apo-(acetyl-CoA:carbon-dioxide ligase (ADP forming)) = AMP + diphosphate + (acetyl-CoA:carbon-dioxide ligase (ADP forming))." [EC:6.3.4.15]
subset: gosubset_prok
synonym: "acetyl CoA holocarboxylase synthetase activity" EXACT [EC:6.3.4.15]
synonym: "acetyl coenzyme A holocarboxylase synthetase activity" EXACT [EC:6.3.4.15]
synonym: "acetyl-CoA carboxylase biotin holoenzyme synthetase activity" EXACT [EC:6.3.4.15]
synonym: "biotin holoenzyme synthetase activity" EXACT [EC:6.3.4.15]
synonym: "biotin--[acetyl-CoA carboxylase] synthetase activity" EXACT [EC:6.3.4.15]
synonym: "biotin--protein ligase activity" RELATED [EC:6.3.4.15]
synonym: "biotin-acetyl coenzyme A carboxylase synthetase activity" EXACT [EC:6.3.4.15]
synonym: "biotin-acetyl-CoA carboxylase synthetase" BROAD [EC:6.3.4.15]
synonym: "biotin-acetyl-CoA-carboxylase ligase activity" EXACT [EC:6.3.4.15]
synonym: "biotin:apo-acetyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)" EXACT [EC:6.3.4.15]
synonym: "biotin:apocarboxylase ligase activity" EXACT [EC:6.3.4.15]
synonym: "HCS" RELATED [EC:6.3.4.15]
xref: EC:6.3.4.15
xref: MetaCyc:BIOTINLIG-RXN
is_a: GO:0018271 ! biotin-protein ligase activity

[Term]
id: GO:0004078
name: biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + biotin + apo-(3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming))." [EC:6.3.4.11]
synonym: "beta-methylcrotonyl coenzyme A holocarboxylase synthetase activity" EXACT [EC:6.3.4.11]
synonym: "biotin--[methylcrotonoyl-CoA-carboxylase] synthetase activity" EXACT [EC:6.3.4.11]
synonym: "biotin-beta-methylcrotonyl coenzyme A carboxylase synthetase activity" EXACT [EC:6.3.4.11]
synonym: "biotin-methylcrotonoyl-CoA-carboxylase ligase activity" EXACT [EC:6.3.4.11]
synonym: "biotin-methylcrotonoyl-CoA-carboxylase synthetase" BROAD [EC:6.3.4.11]
synonym: "biotin:apo-3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)" EXACT [EC:6.3.4.11]
synonym: "holocarboxylase-synthetase activity" EXACT [EC:6.3.4.11]
xref: EC:6.3.4.11
xref: MetaCyc:6.3.4.11-RXN
is_a: GO:0018271 ! biotin-protein ligase activity

[Term]
id: GO:0004079
name: biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + biotin + apo-(methylmalonyl-CoA:pyruvate carboxytransferase) = AMP + diphosphate + (methylmalonyl-CoA:pyruvate carboxytransferase)." [EC:6.3.4.9]
synonym: "biotin--[methylmalonyl-CoA-carboxyltransferase] ligase activity" EXACT [EC:6.3.4.9]
synonym: "biotin--[methylmalonyl-CoA-carboxyltransferase] synthetase activity" EXACT [EC:6.3.4.9]
synonym: "biotin--[methylmalonyl-CoA-carboxytransferase] synthetase activity" EXACT [EC:6.3.4.9]
synonym: "biotin-[methylmalonyl-CoA-carboxyltransferase] ligase activity" EXACT []
synonym: "biotin-methylmalonyl coenzyme A carboxyltransferase synthetase activity" EXACT [EC:6.3.4.9]
synonym: "biotin-methylmalonyl-CoA-carboxyltransferase ligase activity" EXACT [EC:6.3.4.9]
synonym: "biotin-methylmalonyl-CoA-carboxyltransferase synthetase" BROAD [EC:6.3.4.9]
synonym: "biotin-methylmalonyl-CoA-carboxytransferase ligase activity" EXACT [EC:6.3.4.9]
synonym: "biotin-methylmalonyl-CoA-carboxytransferase synthetase activity" EXACT [EC:6.3.4.9]
synonym: "biotin-transcarboxylase synthetase activity" EXACT [EC:6.3.4.9]
synonym: "biotin:apomethylmalonyl-CoA:pyruvate carboxyltransferase ligase (AMP-forming)" EXACT [EC:6.3.4.9]
synonym: "biotin:apomethylmalonyl-CoA:pyruvate carboxytransferase ligase (AMP-forming)" EXACT [EC:6.3.4.9]
synonym: "methylmalonyl coenzyme A holotranscarboxylase synthetase activity" EXACT [EC:6.3.4.9]
xref: EC:6.3.4.9
xref: MetaCyc:6.3.4.9-RXN
is_a: GO:0018271 ! biotin-protein ligase activity

[Term]
id: GO:0004080
name: biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + biotin + apo-(propanoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (propanoyl-CoA:carbon-dioxide ligase (ADP-forming))." [EC:6.3.4.10]
synonym: "biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] synthetase activity" EXACT [EC:6.3.4.10]
synonym: "biotin-propionyl coenzyme A carboxylase synthetase activity" EXACT [EC:6.3.4.10]
synonym: "biotin-propionyl-CoA-carboxylase (ATP-hydrolysing) ligase activity" EXACT [EC:6.3.4.10]
synonym: "biotin-propionyl-CoA-carboxylase (ATP-hydrolysing) synthetase activity" EXACT [EC:6.3.4.10]
synonym: "biotin:apo-propanoyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)" EXACT [EC:6.3.4.10]
synonym: "holocarboxylase synthetase activity" EXACT [EC:6.3.4.10]
synonym: "propionyl coenzyme A holocarboxylase synthetase activity" EXACT [EC:6.3.4.10]
synonym: "propionyl-CoA holocarboxylase synthetase activity" EXACT [EC:6.3.4.10]
xref: EC:6.3.4.10
xref: MetaCyc:6.3.4.10-RXN
is_a: GO:0018271 ! biotin-protein ligase activity

[Term]
id: GO:0004081
name: bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity
namespace: molecular_function
def: "Catalysis of the reaction: P(1),P(4)-bis(5'-nucleosyl)tetraphosphate + H2O = NTP + NMP. Acts on bis(5'-guanosyl)-, bis(5'-xanthosyl)-, bis(5'-adenosyl)- and bis(5'-uridyl)-tetraphosphate." [EC:3.6.1.17, PMID:4955726]
subset: gosubset_prok
synonym: "1-P,4-P-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase activity" EXACT [EC:3.6.1.17]
synonym: "Ap(4)A hydrolase activity" BROAD [EC:3.6.1.17]
synonym: "Ap(4)Aase activity" BROAD [EC:3.6.1.17]
synonym: "Ap4A hydrolase activity" BROAD [EC:3.6.1.17]
synonym: "Ap4Aase activity" BROAD [EC:3.6.1.17]
synonym: "bis(5'-adenosyl)-tetraphosphatase activity" NARROW [EC:3.6.1.17]
synonym: "bis(5'-guanosyl)-tetraphosphatase activity" NARROW [EC:3.6.1.17]
synonym: "diadenosine 5',5'''-P(1),P(4)-tetraphosphate asymmetrical hydrolase activity" EXACT [EC:3.6.1.17]
synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase activity" EXACT [EC:3.6.1.17]
synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate hydrolase" NARROW []
synonym: "diadenosine P1,P4-tetraphosphatase activity" EXACT [EC:3.6.1.17]
synonym: "diadenosinetetraphosphatase (asymmetrical) activity" NARROW [EC:3.6.1.17]
synonym: "diguanosinetetraphosphatase (asymmetrical) activity" NARROW [EC:3.6.1.17]
synonym: "dinucleoside tetraphosphatase activity" EXACT [EC:3.6.1.17]
synonym: "dinucleosidetetraphosphatase (asymmetrical) activity" EXACT [EC:3.6.1.17]
synonym: "P1,P4-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase activity" EXACT [EC:3.6.1.17]
xref: EC:3.6.1.17
xref: MetaCyc:3.6.1.17-RXN
xref: RHEA:22487
is_a: GO:0008796 ! bis(5'-nucleosyl)-tetraphosphatase activity

[Term]
id: GO:0004082
name: bisphosphoglycerate mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate." [EC:5.4.2.4]
synonym: "2,3-bisphosphoglycerate mutase activity" EXACT [EC:5.4.2.4]
synonym: "2,3-bisphosphoglycerate synthase activity" EXACT [EC:5.4.2.4]
synonym: "2,3-diphosphoglycerate mutase activity" EXACT [EC:5.4.2.4]
synonym: "2,3-diphosphoglycerate synthase activity" EXACT [EC:5.4.2.4]
synonym: "2,3-diphosphoglyceromutase activity" EXACT [EC:5.4.2.4]
synonym: "3-phospho-D-glycerate 1,2-phosphomutase activity" EXACT [EC:5.4.2.4]
synonym: "biphosphoglycerate synthase activity" EXACT [EC:5.4.2.4]
synonym: "bisphosphoglycerate synthase activity" EXACT [EC:5.4.2.4]
synonym: "bisphosphoglyceromutase" BROAD [EC:5.4.2.4]
synonym: "BPGM activity" EXACT [EC:5.4.2.4]
synonym: "diphosphoglycerate mutase activity" EXACT [EC:5.4.2.4]
synonym: "diphosphoglyceric mutase activity" EXACT [EC:5.4.2.4]
synonym: "diphosphoglyceromutase activity" EXACT [EC:5.4.2.4]
synonym: "DPGM" RELATED [EC:5.4.2.4]
synonym: "glycerate phosphomutase activity" EXACT [EC:5.4.2.4]
xref: EC:5.4.2.4
xref: MetaCyc:BISPHOSPHOGLYCERATE-MUTASE-RXN
xref: RHEA:17768
is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases

[Term]
id: GO:0004083
name: bisphosphoglycerate 2-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-bisphospho-D-glycerate + H(2)O = 3-phospho-D-glycerate + phosphate." [EC:3.1.3.13, RHEA:21907]
synonym: "2,3-bisphospho-D-glycerate 2-phosphohydrolase activity" BROAD [EC:3.1.3.13]
xref: EC:3.1.3.13
xref: KEGG:R01516
xref: MetaCyc:BISPHOSPHOGLYCERATE-PHOSPHATASE-RXN
xref: RHEA:21907
is_a: GO:0034416 ! bisphosphoglycerate phosphatase activity

[Term]
id: GO:0004084
name: branched-chain-amino-acid transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: a branched-chain amino acid + 2-oxoglutarate = L-glutamate + a 2-oxocarboxylate derived from the branched-chain amino acid." [EC:2.6.1.42, GOC:mah]
subset: gosubset_prok
synonym: "branched-chain amino acid aminotransferase activity" EXACT []
synonym: "branched-chain amino acid-glutamate transaminase activity" EXACT [EC:2.6.1.42]
synonym: "branched-chain aminotransferase activity" EXACT [EC:2.6.1.42]
synonym: "branched-chain-amino-acid:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.42]
synonym: "glutamate-branched-chain amino acid transaminase activity" EXACT [EC:2.6.1.42]
synonym: "L-branched chain amino acid aminotransferase activity" EXACT [EC:2.6.1.42]
synonym: "transaminase B activity" RELATED [EC:2.6.1.42]
xref: EC:2.6.1.42
xref: Reactome:REACT_103033 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2], Schizosaccharomyces pombe"
xref: Reactome:REACT_104255 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2], Bos taurus"
xref: Reactome:REACT_109061 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1], Rattus norvegicus"
xref: Reactome:REACT_112447 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1], Xenopus tropicalis"
xref: Reactome:REACT_1136 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1], Homo sapiens"
xref: Reactome:REACT_2034 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2], Homo sapiens"
xref: Reactome:REACT_21283 "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1], Homo sapiens"
xref: Reactome:REACT_21409 "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2], Homo sapiens"
xref: Reactome:REACT_29623 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1], Drosophila melanogaster"
xref: Reactome:REACT_31174 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2], Dictyostelium discoideum"
xref: Reactome:REACT_31737 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1], Gallus gallus"
xref: Reactome:REACT_31924 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1], Staphylococcus aureus N315"
xref: Reactome:REACT_32127 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1], Canis familiaris"
xref: Reactome:REACT_76927 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2], Mus musculus"
xref: Reactome:REACT_81549 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1], Schizosaccharomyces pombe"
xref: Reactome:REACT_84147 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1], Dictyostelium discoideum"
xref: Reactome:REACT_85686 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1], Mycobacterium tuberculosis"
xref: Reactome:REACT_87300 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2], Canis familiaris"
xref: Reactome:REACT_87826 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2], Caenorhabditis elegans"
xref: Reactome:REACT_89738 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2], Drosophila melanogaster"
xref: Reactome:REACT_93129 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1], Saccharomyces cerevisiae"
xref: Reactome:REACT_95349 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2], Rattus norvegicus"
xref: Reactome:REACT_95545 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1], Mus musculus"
xref: Reactome:REACT_96261 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2], Sus scrofa"
xref: Reactome:REACT_96398 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1], Danio rerio"
xref: Reactome:REACT_97251 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2], Xenopus tropicalis"
xref: Reactome:REACT_97510 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1], Caenorhabditis elegans"
xref: Reactome:REACT_97898 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2], Saccharomyces cerevisiae"
xref: Reactome:REACT_99130 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1], Taeniopygia guttata"
xref: Reactome:REACT_99998 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1], Bos taurus"
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0004085
name: butyryl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: butanoyl-CoA + electron-transfer flavoprotein = 2-butenoyl-CoA + reduced electron-transfer flavoprotein." [EC:1.3.8.1]
subset: gosubset_prok
synonym: "3-hydroxyacyl CoA reductase activity" EXACT [EC:1.3.8.1]
synonym: "butanoyl-CoA:(acceptor) 2,3-oxidoreductase activity" EXACT [EC:1.3.8.1]
synonym: "butanoyl-CoA:acceptor 2,3-oxidoreductase activity" EXACT [EC:1.3.8.1]
synonym: "butyryl coenzyme A dehydrogenase activity" EXACT [EC:1.3.8.1]
synonym: "butyryl dehydrogenase activity" EXACT [EC:1.3.8.1]
synonym: "enoyl-coenzyme A reductase activity" EXACT [EC:1.3.8.1]
synonym: "ethylene reductase activity" EXACT [EC:1.3.8.1]
synonym: "short-chain acyl CoA dehydrogenase activity" EXACT [EC:1.3.8.1]
synonym: "short-chain acyl-coenzyme A dehydrogenase activity" EXACT [EC:1.3.8.1]
synonym: "short-chain-acyl-CoA dehydrogenase activity" RELATED [EC:1.3.8.1]
synonym: "unsaturated acyl coenzyme A reductase activity" EXACT [EC:1.3.8.1]
synonym: "unsaturated acyl-CoA reductase activity" RELATED [EC:1.3.8.1]
xref: EC:1.3.8.1
xref: KEGG:R01178
xref: MetaCyc:BUTYRYL-COA-DEHYDROGENASE-RXN
xref: UM-BBD_reactionID:r0013
is_a: GO:0052890 ! oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor

[Term]
id: GO:0004086
name: obsolete carbamoyl-phosphate synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of a reaction that results in the formation of carbamoyl phosphate." [EC:6.3.4.16, EC:6.3.5.5, GOC:mah]
comment: This term was made obsolete because it is a grouping term based on name, rather than on function.
synonym: "carbamoyl phosphate synthase activity" EXACT []
synonym: "carbamoyl-phosphate synthase activity" EXACT []
is_obsolete: true
consider: GO:0004087
consider: GO:0004088

[Term]
id: GO:0004087
name: carbamoyl-phosphate synthase (ammonia) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 ATP + CO(2) + H(2)O + NH(4)(+) = 2 ADP + carbamoyl phosphate + 5 H(+) + phosphate." [EC:6.3.4.16, RHEA:10627]
subset: gosubset_prok
synonym: "carbamoyl phosphate synthase (ammonia) activity" EXACT []
synonym: "carbamoyl-phosphate synthetase (ammonia) activity" EXACT [EC:6.3.4.16]
synonym: "carbamoyl-phosphate synthetase I activity" EXACT [EC:6.3.4.16]
synonym: "carbamoylphosphate synthase (ammonia)" EXACT [EC:6.3.4.16]
synonym: "carbamoylphosphate synthase activity" EXACT [EC:6.3.4.16]
synonym: "carbamoylphosphate synthetase (ammonia) activity" EXACT [EC:6.3.4.16]
synonym: "carbamylphosphate synthetase activity" EXACT [EC:6.3.4.16]
synonym: "carbamylphosphate synthetase I" RELATED [EC:6.3.4.16]
synonym: "carbmoylphosphate synthetase activity" EXACT [EC:6.3.4.16]
synonym: "carbon-dioxide--ammonia ligase activity" EXACT [EC:6.3.4.16]
synonym: "carbon-dioxide:ammonia ligase (ADP-forming, carbamate-phosphorylating)" EXACT [EC:6.3.4.16]
synonym: "CPS I activity" NARROW [EC:6.3.4.16]
xref: EC:6.3.4.16
xref: KEGG:R00149
xref: MetaCyc:6.3.4.16-RXN
xref: Reactome:REACT_104425 "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial], Bos taurus"
xref: Reactome:REACT_112052 "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial], Plasmodium falciparum"
xref: Reactome:REACT_112191 "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial], Saccharomyces cerevisiae"
xref: Reactome:REACT_112781 "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial], Schizosaccharomyces pombe"
xref: Reactome:REACT_1701 "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial], Homo sapiens"
xref: Reactome:REACT_28657 "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial], Gallus gallus"
xref: Reactome:REACT_32408 "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial], Staphylococcus aureus N315"
xref: Reactome:REACT_32830 "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial], Taeniopygia guttata"
xref: Reactome:REACT_45108 "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial], Mus musculus"
xref: Reactome:REACT_78285 "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial], Xenopus tropicalis"
xref: Reactome:REACT_79612 "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial], Danio rerio"
xref: Reactome:REACT_81920 "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial], Sus scrofa"
xref: Reactome:REACT_87223 "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial], Canis familiaris"
xref: Reactome:REACT_89630 "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial], Rattus norvegicus"
xref: RHEA:10627
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0004088
name: carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 ATP + L-glutamine + CO2 + H2O = 2 ADP + phosphate + glutamate + carbamoyl phosphate." [EC:6.3.5.5]
subset: gosubset_prok
synonym: "carbamoyl phosphate synthase (glutamine-hydrolyzing) activity" EXACT []
synonym: "carbamoyl phosphate synthetase activity" EXACT [EC:6.3.5.5]
synonym: "carbamoyl-phosphate synthase (glutamine-hydrolysing) activity" EXACT [EC:6.3.5.5]
synonym: "carbamoyl-phosphate synthetase (glutamine-hydrolysing) activity" EXACT [EC:6.3.5.5]
synonym: "carbamoyl-phosphate synthetase (glutamine-hydrolyzing) activity" EXACT [EC:6.3.5.5]
synonym: "carbamoylphosphate synthetase II activity" EXACT [EC:6.3.5.5]
synonym: "carbamyl phosphate synthetase (glutamine) activity" EXACT [EC:6.3.5.5]
synonym: "carbon-dioxide::L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) activity" EXACT [EC:6.3.5.5]
synonym: "CPS activity" EXACT [EC:6.3.5.5]
synonym: "GD-CPSase activity" EXACT [EC:6.3.5.5]
synonym: "glutamine-dependent carbamoyl-phosphate synthase activity" EXACT [EC:6.3.5.5]
synonym: "glutamine-dependent carbamyl phosphate synthetase activity" EXACT [EC:6.3.5.5]
synonym: "hydrogen-carbonate:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) activity" EXACT [EC:6.3.5.5]
xref: EC:6.3.5.5
xref: MetaCyc:CARBPSYN-RXN
xref: Reactome:REACT_102934 "L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_115736 "L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate, Gallus gallus"
xref: Reactome:REACT_28976 "L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate, Staphylococcus aureus N315"
xref: Reactome:REACT_29452 "L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate, Taeniopygia guttata"
xref: Reactome:REACT_30926 "L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_478 "L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate, Homo sapiens"
xref: Reactome:REACT_77966 "L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate, Bos taurus"
xref: Reactome:REACT_79566 "L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate, Canis familiaris"
xref: Reactome:REACT_83511 "L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate, Mus musculus"
xref: Reactome:REACT_86599 "L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate, Caenorhabditis elegans"
xref: Reactome:REACT_86815 "L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate, Plasmodium falciparum"
xref: Reactome:REACT_88920 "L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate, Danio rerio"
xref: Reactome:REACT_89432 "L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_94822 "L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate, Drosophila melanogaster"
xref: Reactome:REACT_96943 "L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate, Rattus norvegicus"
xref: RHEA:24654
is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor

[Term]
id: GO:0004089
name: carbonate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2CO3 = CO2 + H2O." [EC:4.2.1.1]
subset: gosubset_prok
synonym: "anhydrase activity" EXACT [EC:4.2.1.1]
synonym: "carbonate anhydrase activity" EXACT [EC:4.2.1.1]
synonym: "carbonate hydro-lyase (carbon-dioxide-forming)" EXACT [EC:4.2.1.1]
synonym: "carbonate hydro-lyase activity" EXACT [EC:4.2.1.1]
synonym: "carbonic acid anhydrase activity" EXACT [EC:4.2.1.1]
synonym: "carbonic anhydrase A" RELATED [EC:4.2.1.1]
synonym: "carbonic anhydrase activity" EXACT []
synonym: "carbonic dehydratase activity" EXACT [EC:4.2.1.1]
synonym: "carboxyanhydrase activity" EXACT [EC:4.2.1.1]
xref: EC:4.2.1.1
xref: MetaCyc:CARBODEHYDRAT-RXN
xref: RHEA:10751
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0004090
name: carbonyl reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+." [EC:1.1.1.184]
subset: gosubset_prok
synonym: "aldehyde reductase 1" RELATED [EC:1.1.1.184]
synonym: "aldehyde reductase I activity" RELATED [EC:1.1.1.184]
synonym: "ALR3" RELATED [EC:1.1.1.184]
synonym: "carbonyl reductase activity" EXACT [EC:1.1.1.184]
synonym: "NADPH-dependent carbonyl reductase activity" EXACT [EC:1.1.1.184]
synonym: "NADPH2-dependent carbonyl reductase activity" EXACT [EC:1.1.1.184]
synonym: "nonspecific NADPH-dependent carbonyl reductase activity" EXACT [EC:1.1.1.184]
synonym: "prostaglandin 9-ketoreductase activity" NARROW [EC:1.1.1.184]
synonym: "secondary-alcohol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.184]
synonym: "xenobiotic ketone reductase activity" NARROW [EC:1.1.1.184]
xref: EC:1.1.1.184
xref: MetaCyc:CARBONYL-REDUCTASE-NADPH-RXN
xref: RHEA:19260
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004092
name: carnitine O-acetyltransferase activity
namespace: molecular_function
alt_id: GO:0004093
alt_id: GO:0004094
def: "Catalysis of the reaction: acetyl-CoA + carnitine = (R)-O-acetylcarnitine + CoA." [EC:2.3.1.7, RHEA:21139]
subset: gosubset_prok
synonym: "acetyl-CoA-carnitine O-acetyltransferase activity" EXACT [EC:2.3.1.7]
synonym: "acetyl-CoA:carnitine O-acetyltransferase activity" EXACT [EC:2.3.1.7]
synonym: "acetylcarnitine transferase activity" EXACT [EC:2.3.1.7]
synonym: "carnitine acetyl coenzyme A transferase activity" EXACT [EC:2.3.1.7]
synonym: "carnitine acetylase activity" EXACT [EC:2.3.1.7]
synonym: "carnitine acetyltransferase activity" EXACT [EC:2.3.1.7]
synonym: "carnitine O-acetyltransferase I activity" NARROW []
synonym: "carnitine O-acetyltransferase II activity" NARROW []
synonym: "carnitine-acetyl-CoA transferase activity" EXACT [EC:2.3.1.7]
synonym: "CATC" RELATED [EC:2.3.1.7]
xref: EC:2.3.1.7
xref: KEGG:R02396
xref: MetaCyc:CARNITINE-O-ACETYLTRANSFERASE-RXN
xref: Reactome:REACT_106381 "propionyl-CoA + carnitine => propionylcarnitine + CoASH, Gallus gallus"
xref: Reactome:REACT_107669 "acetyl-CoA + carnitine => acetylcarnitine + CoASH, Rattus norvegicus"
xref: Reactome:REACT_16949 "propionyl-CoA + carnitine => propionylcarnitine + CoASH, Homo sapiens"
xref: Reactome:REACT_16977 "acetyl-CoA + carnitine => acetylcarnitine + CoASH, Homo sapiens"
xref: Reactome:REACT_32144 "propionyl-CoA + carnitine => propionylcarnitine + CoASH, Xenopus tropicalis"
xref: Reactome:REACT_34276 "propionyl-CoA + carnitine => propionylcarnitine + CoASH, Bos taurus"
xref: Reactome:REACT_34588 "acetyl-CoA + carnitine => acetylcarnitine + CoASH, Sus scrofa"
xref: Reactome:REACT_34633 "propionyl-CoA + carnitine => propionylcarnitine + CoASH, Taeniopygia guttata"
xref: Reactome:REACT_34692 "propionyl-CoA + carnitine => propionylcarnitine + CoASH, Sus scrofa"
xref: Reactome:REACT_77010 "acetyl-CoA + carnitine => acetylcarnitine + CoASH, Danio rerio"
xref: Reactome:REACT_77298 "propionyl-CoA + carnitine => propionylcarnitine + CoASH, Mus musculus"
xref: Reactome:REACT_78054 "propionyl-CoA + carnitine => propionylcarnitine + CoASH, Rattus norvegicus"
xref: Reactome:REACT_79550 "acetyl-CoA + carnitine => acetylcarnitine + CoASH, Taeniopygia guttata"
xref: Reactome:REACT_85497 "acetyl-CoA + carnitine => acetylcarnitine + CoASH, Gallus gallus"
xref: Reactome:REACT_87499 "acetyl-CoA + carnitine => acetylcarnitine + CoASH, Xenopus tropicalis"
xref: Reactome:REACT_87701 "propionyl-CoA + carnitine => propionylcarnitine + CoASH, Canis familiaris"
xref: Reactome:REACT_90661 "acetyl-CoA + carnitine => acetylcarnitine + CoASH, Mus musculus"
xref: Reactome:REACT_92700 "propionyl-CoA + carnitine => propionylcarnitine + CoASH, Danio rerio"
xref: Reactome:REACT_94633 "acetyl-CoA + carnitine => acetylcarnitine + CoASH, Bos taurus"
xref: Reactome:REACT_98210 "acetyl-CoA + carnitine => acetylcarnitine + CoASH, Canis familiaris"
xref: RHEA:21139
is_a: GO:0016406 ! carnitine O-acyltransferase activity
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0004095
name: carnitine O-palmitoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine." [EC:2.3.1.21]
synonym: "acylcarnitine transferase activity" EXACT [EC:2.3.1.21]
synonym: "carnitine palmitoyltransferase activity" EXACT [EC:2.3.1.21]
synonym: "carnitine palmitoyltransferase I" RELATED [EC:2.3.1.21]
synonym: "carnitine palmitoyltransferase II" RELATED [EC:2.3.1.21]
synonym: "carnitine palmitoyltransferase-A" RELATED [EC:2.3.1.21]
synonym: "CPT" RELATED [EC:2.3.1.21]
synonym: "CPT I (outer membrane carnitine palmitoyl transferase)" RELATED [EC:2.3.1.21]
synonym: "CPT-A" RELATED [EC:2.3.1.21]
synonym: "CPT-B" RELATED [EC:2.3.1.21]
synonym: "CPTi" RELATED [EC:2.3.1.21]
synonym: "CPTo" RELATED [EC:2.3.1.21]
synonym: "L-carnitine palmitoyltransferase activity" EXACT [EC:2.3.1.21]
synonym: "outer malonyl-CoA inhibitable carnitine palmitoyltransferase activity" EXACT [EC:2.3.1.21]
synonym: "palmitoyl-CoA:L-carnitine O-palmitoyltransferase activity" EXACT [EC:2.3.1.21]
synonym: "palmitoylcarnitine transferase activity" EXACT [EC:2.3.1.21]
xref: EC:2.3.1.21
xref: MetaCyc:CARNITINE-O-PALMITOYLTRANSFERASE-RXN
xref: Reactome:REACT_106987 "palmitoyl-CoA + carnitine => palmitoylcarnitine + CoASH, Drosophila melanogaster"
xref: Reactome:REACT_108163 "palmitoyl-CoA + carnitine => palmitoylcarnitine + CoASH, Caenorhabditis elegans"
xref: Reactome:REACT_11133 "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine, Homo sapiens"
xref: Reactome:REACT_11185 "palmitoyl-CoA + carnitine => palmitoylcarnitine + CoASH, Homo sapiens"
xref: Reactome:REACT_30467 "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine, Danio rerio"
xref: Reactome:REACT_33707 "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine, Mus musculus"
xref: Reactome:REACT_34534 "palmitoyl-CoA + carnitine => palmitoylcarnitine + CoASH, Taeniopygia guttata"
xref: Reactome:REACT_77063 "palmitoyl-CoA + carnitine => palmitoylcarnitine + CoASH, Danio rerio"
xref: Reactome:REACT_78400 "palmitoyl-CoA + carnitine => palmitoylcarnitine + CoASH, Gallus gallus"
xref: Reactome:REACT_78721 "palmitoyl-CoA + carnitine => palmitoylcarnitine + CoASH, Xenopus tropicalis"
xref: Reactome:REACT_83067 "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine, Canis familiaris"
xref: Reactome:REACT_83898 "palmitoyl-CoA + carnitine => palmitoylcarnitine + CoASH, Rattus norvegicus"
xref: Reactome:REACT_86504 "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine, Xenopus tropicalis"
xref: Reactome:REACT_86687 "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine, Rattus norvegicus"
xref: Reactome:REACT_87240 "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine, Gallus gallus"
xref: Reactome:REACT_88030 "palmitoyl-CoA + carnitine => palmitoylcarnitine + CoASH, Bos taurus"
xref: Reactome:REACT_88075 "palmitoyl-CoA + carnitine => palmitoylcarnitine + CoASH, Mus musculus"
xref: Reactome:REACT_89612 "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine, Bos taurus"
xref: Reactome:REACT_92120 "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine, Caenorhabditis elegans"
xref: Reactome:REACT_94774 "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine, Drosophila melanogaster"
xref: Reactome:REACT_95110 "palmitoyl-CoA + carnitine => palmitoylcarnitine + CoASH, Canis familiaris"
xref: Reactome:REACT_95133 "palmitoyl-CoA + carnitine => palmitoylcarnitine + CoASH, Sus scrofa"
xref: Reactome:REACT_95851 "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine, Sus scrofa"
xref: Reactome:REACT_99269 "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine, Taeniopygia guttata"
xref: RHEA:12664
is_a: GO:0016406 ! carnitine O-acyltransferase activity
is_a: GO:0016416 ! O-palmitoyltransferase activity

[Term]
id: GO:0004096
name: catalase activity
namespace: molecular_function
alt_id: GO:0016952
alt_id: GO:0016953
def: "Catalysis of the reaction: 2 hydrogen peroxide = O2 + 2 H2O." [EC:1.11.1.6]
subset: gosubset_prok
synonym: "bacterial catalase-peroxidase activity" NARROW []
synonym: "caperase activity" EXACT [EC:1.11.1.6]
synonym: "CAT" RELATED [EC:1.11.1.6]
synonym: "catalase reaction" EXACT []
synonym: "catalase-peroxidase activity" EXACT [EC:1.11.1.6]
synonym: "equilase activity" EXACT [EC:1.11.1.6]
synonym: "haem catalase activity" NARROW []
synonym: "heme catalase activity" NARROW []
synonym: "hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.6]
synonym: "manganese catalase activity" NARROW []
synonym: "optidase activity" EXACT [EC:1.11.1.6]
xref: EC:1.11.1.6
xref: MetaCyc:CATAL-RXN
xref: Reactome:REACT_101648 "2 H2O2 => O2 + 2 H2O, Gallus gallus"
xref: Reactome:REACT_108235 "2 H2O2 => O2 + 2 H2O, Saccharomyces cerevisiae"
xref: Reactome:REACT_112160 "2 H2O2 => O2 + 2 H2O, Caenorhabditis elegans"
xref: Reactome:REACT_30681 "2 H2O2 => O2 + 2 H2O, Escherichia coli"
xref: Reactome:REACT_30704 "2 H2O2 => O2 + 2 H2O, Drosophila melanogaster"
xref: Reactome:REACT_30957 "2 H2O2 => O2 + 2 H2O, Mus musculus"
xref: Reactome:REACT_615 "2 H2O2 => O2 + 2 H2O, Homo sapiens"
xref: Reactome:REACT_79013 "2 H2O2 => O2 + 2 H2O, Taeniopygia guttata"
xref: Reactome:REACT_79757 "2 H2O2 => O2 + 2 H2O, Schizosaccharomyces pombe"
xref: Reactome:REACT_85074 "2 H2O2 => O2 + 2 H2O, Staphylococcus aureus N315"
xref: Reactome:REACT_85170 "2 H2O2 => O2 + 2 H2O, Bos taurus"
xref: Reactome:REACT_87638 "2 H2O2 => O2 + 2 H2O, Dictyostelium discoideum"
xref: Reactome:REACT_89864 "2 H2O2 => O2 + 2 H2O, Sus scrofa"
xref: Reactome:REACT_90743 "2 H2O2 => O2 + 2 H2O, Rattus norvegicus"
xref: Reactome:REACT_91037 "2 H2O2 => O2 + 2 H2O, Danio rerio"
xref: Reactome:REACT_91307 "2 H2O2 => O2 + 2 H2O, Canis familiaris"
xref: Reactome:REACT_96832 "2 H2O2 => O2 + 2 H2O, Xenopus tropicalis"
xref: RHEA:20312
xref: UM-BBD_enzymeID:e0834
is_a: GO:0004601 ! peroxidase activity

[Term]
id: GO:0004097
name: catechol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 catechol + O2 = 2 1,2-benzoquinone + 2 H2O." [EC:1.10.3.1]
comment: GO:0004097 describes oxidation of catechols (i.e., o-diphenols) to the corresponding o-quinones. For monooxygenation of monophenols, consider instead the term 'monophenol monooxygenase activity ; GO:0004503'.
subset: gosubset_prok
synonym: "1,2-benzenediol:oxygen oxidoreductase activity" EXACT [EC:1.10.3.1]
synonym: "catecholase" BROAD [EC:1.10.3.1]
synonym: "diphenol oxidase activity" EXACT [EC:1.10.3.1]
synonym: "dopa oxidase" BROAD [EC:1.10.3.1]
synonym: "o-diphenol oxidoreductase" BROAD [EC:1.10.3.1]
synonym: "o-diphenol:oxygen oxidoreductase" BROAD [EC:1.10.3.1]
synonym: "o-diphenolase activity" EXACT [EC:1.10.3.1]
synonym: "phenolase activity" BROAD [EC:1.10.3.1]
synonym: "polyphenol oxidase activity" EXACT [EC:1.10.3.1]
synonym: "pyrocatechol oxidase" BROAD [EC:1.10.3.1]
synonym: "tyrosinase activity" BROAD [EC:1.10.3.1]
xref: EC:1.10.3.1
xref: MetaCyc:CATECHOL-OXIDASE-RXN
xref: RHEA:21635
is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor

[Term]
id: GO:0004098
name: cerebroside-sulfatase activity
namespace: molecular_function
def: "Catalysis of the reaction: a cerebroside 3-sulfate + H2O = a cerebroside + sulfate." [EC:3.1.6.8]
subset: gosubset_prok
synonym: "arylsulfatase A activity" EXACT [EC:3.1.6.8]
synonym: "cerebroside sulfate sulfatase activity" EXACT [EC:3.1.6.8]
synonym: "cerebroside-3-sulfate 3-sulfohydrolase activity" EXACT [EC:3.1.6.8]
synonym: "cerebroside-sulphatase activity" EXACT []
xref: EC:3.1.6.8
xref: MetaCyc:CEREBROSIDE-SULFATASE-RXN
xref: Reactome:REACT_115556 "Arylsulfatase A hydrolyses sulfate from sulfatide to form cerebroside, Homo sapiens"
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0004099
name: chitin deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: chitin + H2O = chitosan + acetate." [EC:3.5.1.41]
subset: gosubset_prok
synonym: "chitin amidohydrolase activity" EXACT [EC:3.5.1.41]
xref: EC:3.5.1.41
xref: MetaCyc:CHITIN-DEACETYLASE-RXN
xref: RHEA:10467
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0019213 ! deacetylase activity

[Term]
id: GO:0004100
name: chitin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + [->4)-N-acetyl-beta-D-glucosaminyl-(1-](n) = UDP + [->4)-N-acetyl-beta-D-glucosaminyl-(1-](n+1)." [EC:2.4.1.16]
subset: gosubset_prok
synonym: "chitin synthetase activity" EXACT [EC:2.4.1.16]
synonym: "chitin-UDP acetyl-glucosaminyl transferase activity" EXACT [EC:2.4.1.16]
synonym: "chitin-UDP N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.16]
synonym: "chitin-uridine diphosphate acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.16]
synonym: "trans-N-acetylglucosaminosylase activity" EXACT [EC:2.4.1.16]
synonym: "UDP-N-acetyl-D-glucosamine:chitin 4-beta-N-acetylglucosaminyl-transferase activity" EXACT [EC:2.4.1.16]
xref: EC:2.4.1.16
xref: MetaCyc:CHITIN-SYNTHASE-RXN
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0004102
name: choline O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + choline = acetylcholine + CoA." [EC:2.3.1.6, RHEA:18824]
subset: gosubset_prok
synonym: "acetyl-CoA:choline O-acetyltransferase activity" EXACT [EC:2.3.1.6]
synonym: "CHOACTase activity" EXACT [EC:2.3.1.6]
synonym: "choline acetylase activity" EXACT [EC:2.3.1.6]
synonym: "choline acetyltransferase activity" EXACT [EC:2.3.1.6]
xref: EC:2.3.1.6
xref: KEGG:R01023
xref: MetaCyc:CHOLINE-O-ACETYLTRANSFERASE-RXN
xref: Reactome:REACT_105936 "Cho is acetylated to AcCho by CHAT, Gallus gallus"
xref: Reactome:REACT_108136 "Cho is acetylated to AcCho by CHAT, Taeniopygia guttata"
xref: Reactome:REACT_109278 "Cho is acetylated to AcCho by CHAT, Bos taurus"
xref: Reactome:REACT_15484 "Cho is acetylated to AcCho by CHAT, Homo sapiens"
xref: Reactome:REACT_29952 "Cho is acetylated to AcCho by CHAT, Canis familiaris"
xref: Reactome:REACT_31186 "Cho is acetylated to AcCho by CHAT, Drosophila melanogaster"
xref: Reactome:REACT_77093 "Cho is acetylated to AcCho by CHAT, Danio rerio"
xref: Reactome:REACT_87316 "Cho is acetylated to AcCho by CHAT, Caenorhabditis elegans"
xref: Reactome:REACT_94484 "Cho is acetylated to AcCho by CHAT, Rattus norvegicus"
xref: Reactome:REACT_96109 "Cho is acetylated to AcCho by CHAT, Sus scrofa"
xref: Reactome:REACT_97062 "Cho is acetylated to AcCho by CHAT, Mus musculus"
xref: Reactome:REACT_98162 "Cho is acetylated to AcCho by CHAT, Xenopus tropicalis"
xref: RHEA:18824
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0004103
name: choline kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + choline = ADP + choline phosphate + 2 H(+)." [EC:2.7.1.32, RHEA:12840]
subset: gosubset_prok
synonym: "ATP:choline phosphotransferase activity" EXACT [EC:2.7.1.32]
synonym: "choline kinase (phosphorylating)" EXACT [EC:2.7.1.32]
synonym: "choline phosphokinase activity" EXACT [EC:2.7.1.32]
synonym: "choline-ethanolamine kinase activity" EXACT [EC:2.7.1.32]
xref: EC:2.7.1.32
xref: KEGG:R01021
xref: MetaCyc:CHOLINE-KINASE-RXN
xref: RHEA:12840
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
relationship: part_of GO:0006657 ! CDP-choline pathway

[Term]
id: GO:0004104
name: cholinesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion." [EC:3.1.1.8]
subset: goslim_chembl
subset: gosubset_prok
synonym: "acylcholine acylhydrolase activity" EXACT [EC:3.1.1.8]
synonym: "anticholineesterase activity" EXACT [EC:3.1.1.8]
synonym: "benzoylcholinesterase activity" EXACT [EC:3.1.1.8]
synonym: "BtChoEase activity" EXACT [EC:3.1.1.8]
synonym: "butyrylcholine esterase activity" EXACT [EC:3.1.1.8]
synonym: "butyrylcholinesterase activity" EXACT [EC:3.1.1.8]
synonym: "choline esterase activity" EXACT [EC:3.1.1.8]
synonym: "choline esterase II (unspecific) activity" EXACT [EC:3.1.1.8]
synonym: "non-specific cholinesterase activity" EXACT [EC:3.1.1.8]
synonym: "propionylcholinesterase activity" EXACT [EC:3.1.1.8]
synonym: "pseudocholinesterase activity" EXACT [EC:3.1.1.8]
xref: EC:3.1.1.8
xref: MetaCyc:CHOLINESTERASE-RXN
xref: RHEA:21967
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0004105
name: choline-phosphate cytidylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CTP + choline phosphate = diphosphate + CDP-choline." [EC:2.7.7.15]
subset: gosubset_prok
synonym: "CDP-choline pyrophosphorylase activity" EXACT [EC:2.7.7.15]
synonym: "CDP-choline synthetase activity" EXACT [EC:2.7.7.15]
synonym: "choline phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.15]
synonym: "CTP-phosphocholine cytidylyltransferase activity" EXACT [EC:2.7.7.15]
synonym: "CTP:choline-phosphate cytidylyltransferase activity" EXACT []
synonym: "CTP:phosphocholine cytidylyltransferase activity" EXACT [EC:2.7.7.15]
synonym: "CTP:phosphorylcholine cytidylyltransferase activity" EXACT [EC:2.7.7.15]
synonym: "cytidine diphosphocholine pyrophosphorylase activity" EXACT [EC:2.7.7.15]
synonym: "phosphocholine cytidylyltransferase activity" EXACT [EC:2.7.7.15]
synonym: "phosphorylcholine cytidylyltransferase activity" EXACT [EC:2.7.7.15]
synonym: "phosphorylcholine transferase activity" EXACT [EC:2.7.7.15]
synonym: "phosphorylcholine:CTP cytidylyltransferase activity" EXACT [EC:2.7.7.15]
xref: EC:2.7.7.15
xref: MetaCyc:2.7.7.15-RXN
xref: RHEA:19000
is_a: GO:0070567 ! cytidylyltransferase activity
relationship: part_of GO:0006657 ! CDP-choline pathway

[Term]
id: GO:0004106
name: chorismate mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: chorismate = prephenate." [EC:5.4.99.5, RHEA:13900]
subset: gosubset_prok
synonym: "chorismate pyruvatemutase activity" EXACT [EC:5.4.99.5]
synonym: "hydroxyphenylpyruvate synthase activity" BROAD [EC:5.4.99.5]
xref: EC:5.4.99.5
xref: KEGG:R01715
xref: MetaCyc:CHORISMATEMUT-RXN
xref: RHEA:13900
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0004107
name: chorismate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate." [EC:4.2.3.5, RHEA:21023]
subset: gosubset_prok
synonym: "5-enolpyruvylshikimate-3-phosphate phospholyase activity" EXACT [EC:4.2.3.5]
synonym: "5-O-(1-carboxyvinyl)-3-phosphoshikimate phosphate-lyase (chorismate-forming)" EXACT [EC:4.2.3.5]
synonym: "5-O-(1-carboxyvinyl)-3-phosphoshikimate phosphate-lyase activity" EXACT [EC:4.2.3.5]
xref: EC:4.2.3.5
xref: KEGG:R01714
xref: MetaCyc:CHORISMATE-SYNTHASE-RXN
xref: Reactome:REACT_27204 "Dephosphorylation of EPSP yields chorismate, Mycobacterium tuberculosis"
xref: RHEA:21023
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0004108
name: citrate (Si)-synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the si-face of oxaloacetate; acetyl-CoA thus provides the two carbon atoms of the pro-S carboxymethyl group." [EC:2.3.3.1, ISBN:0121227073]
comment: Note that this function was formerly EC:4.1.3.7.
subset: gosubset_prok
synonym: "(R)-citric synthase activity" EXACT [EC:2.3.3.1]
synonym: "acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-S)-carboxymethyl forming]" RELATED [EC:2.3.3.1]
synonym: "citrate condensing enzyme activity" EXACT [EC:2.3.3.1]
synonym: "citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)->acetyl-CoA) activity" EXACT [EC:2.3.3.1]
synonym: "citrate oxaloacetate-lyase ((pro-3S)-CH2COO-rightacetyl-CoA)" EXACT [EC:2.3.3.1]
synonym: "citrate oxaloacetate-lyase [(pro-3S)-CH2COOrightacetyl-CoA]" RELATED [EC:2.3.3.1]
synonym: "citrate oxaloacetate-lyase, CoA-acetylating activity" EXACT [EC:2.3.3.1]
synonym: "citrate synthase activity" BROAD [EC:2.3.3.1]
synonym: "citrate synthetase activity" EXACT [EC:2.3.3.1]
synonym: "citric synthase activity" EXACT [EC:2.3.3.1]
synonym: "citric-condensing enzyme activity" EXACT [EC:2.3.3.1]
synonym: "citrogenase activity" EXACT [EC:2.3.3.1]
synonym: "condensing enzyme activity" BROAD [EC:2.3.3.1]
synonym: "oxalacetic transacetase activity" EXACT [EC:2.3.3.1]
synonym: "oxaloacetate transacetase activity" EXACT [EC:2.3.3.1]
xref: EC:2.3.3.1
xref: MetaCyc:CITSYN-RXN
xref: Reactome:REACT_100557 "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA, Mus musculus"
xref: Reactome:REACT_100736 "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA, Staphylococcus aureus N315"
xref: Reactome:REACT_103631 "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA, Xenopus tropicalis"
xref: Reactome:REACT_107569 "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA, Rattus norvegicus"
xref: Reactome:REACT_108814 "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA, Bos taurus"
xref: Reactome:REACT_115605 "acetyl-CoA + H2O + oxaloacetate => citrate + CoA, Gallus gallus"
xref: Reactome:REACT_1282 "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA, Homo sapiens"
xref: Reactome:REACT_32191 "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA, Drosophila melanogaster"
xref: Reactome:REACT_33399 "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA, Danio rerio"
xref: Reactome:REACT_81174 "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA, Dictyostelium discoideum"
xref: Reactome:REACT_81802 "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA, Plasmodium falciparum"
xref: Reactome:REACT_83386 "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA, Oryza sativa"
xref: Reactome:REACT_87177 "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA, Arabidopsis thaliana"
xref: Reactome:REACT_88391 "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA, Caenorhabditis elegans"
xref: Reactome:REACT_91540 "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA, Canis familiaris"
xref: Reactome:REACT_94285 "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA, Schizosaccharomyces pombe"
xref: Reactome:REACT_96879 "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA, Sus scrofa"
is_a: GO:0036440 ! citrate synthase activity

[Term]
id: GO:0004109
name: coproporphyrinogen oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: coproporphyrinogen III + 2 H(+) + O(2) = 2 CO(2) + 2 H(2)O + protoporphyrinogen IX." [EC:1.3.3.3, RHEA:18260]
subset: gosubset_prok
synonym: "coprogen oxidase activity" EXACT []
synonym: "coproporphyrinogen-III oxidase activity" EXACT []
synonym: "coproporphyrinogen:oxygen oxidoreductase (decarboxylating)" EXACT [EC:1.3.3.3]
synonym: "coproporphyrinogenase activity" EXACT []
xref: EC:1.3.3.3
xref: KEGG:R03220
xref: MetaCyc:RXN0-1461
xref: Reactome:REACT_100303 "Conversion of coproporphyrinogen III to protoporphyrinogen IX, Dictyostelium discoideum"
xref: Reactome:REACT_102127 "Conversion of coproporphyrinogen III to protoporphyrinogen IX, Plasmodium falciparum"
xref: Reactome:REACT_106413 "Conversion of coproporphyrinogen III to protoporphyrinogen IX, Saccharomyces cerevisiae"
xref: Reactome:REACT_109036 "Conversion of coproporphyrinogen III to protoporphyrinogen IX, Sus scrofa"
xref: Reactome:REACT_109488 "Conversion of coproporphyrinogen III to protoporphyrinogen IX, Drosophila melanogaster"
xref: Reactome:REACT_116046 "coproporphyrinogen III + 2 O2 => protoporphyrinogen IX + 2 H2O2 + 2 CO2, Gallus gallus"
xref: Reactome:REACT_28640 "Conversion of coproporphyrinogen III to protoporphyrinogen IX, Mus musculus"
xref: Reactome:REACT_31610 "Conversion of coproporphyrinogen III to protoporphyrinogen IX, Danio rerio"
xref: Reactome:REACT_33035 "Conversion of coproporphyrinogen III to protoporphyrinogen IX, Taeniopygia guttata"
xref: Reactome:REACT_33168 "Conversion of coproporphyrinogen III to protoporphyrinogen IX, Xenopus tropicalis"
xref: Reactome:REACT_79367 "Conversion of coproporphyrinogen III to protoporphyrinogen IX, Escherichia coli"
xref: Reactome:REACT_82126 "Conversion of coproporphyrinogen III to protoporphyrinogen IX, Oryza sativa"
xref: Reactome:REACT_83357 "Conversion of coproporphyrinogen III to protoporphyrinogen IX, Arabidopsis thaliana"
xref: Reactome:REACT_90082 "Conversion of coproporphyrinogen III to protoporphyrinogen IX, Canis familiaris"
xref: Reactome:REACT_90208 "Conversion of coproporphyrinogen III to protoporphyrinogen IX, Gallus gallus"
xref: Reactome:REACT_91427 "Conversion of coproporphyrinogen III to protoporphyrinogen IX, Rattus norvegicus"
xref: Reactome:REACT_93659 "Conversion of coproporphyrinogen III to protoporphyrinogen IX, Schizosaccharomyces pombe"
xref: Reactome:REACT_9421 "Conversion of coproporphyrinogen III to protoporphyrinogen IX, Homo sapiens"
xref: Reactome:REACT_98194 "Conversion of coproporphyrinogen III to protoporphyrinogen IX, Bos taurus"
xref: RHEA:18260
is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor

[Term]
id: GO:0004110
name: corticosteroid side-chain-isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 11-deoxycorticosterone = 20-hydroxy-3-oxopregn-4-en-21-al." [EC:5.3.1.21, RHEA:17864]
synonym: "11-deoxycorticosterone aldose-ketose-isomerase activity" EXACT [EC:5.3.1.21]
synonym: "11-deoxycorticosterone ketol-isomerase activity" EXACT [EC:5.3.1.21]
xref: EC:5.3.1.21
xref: KEGG:R04165
xref: MetaCyc:CORTICOSTEROID-SIDE-CHAIN-ISOMERASE-RXN
xref: RHEA:17864
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0004111
name: creatine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H(+)." [EC:2.7.3.2, RHEA:17160]
synonym: "adenosine triphosphate-creatine transphosphorylase activity" EXACT [EC:2.7.3.2]
synonym: "ATP:creatine N-phosphotransferase activity" EXACT [EC:2.7.3.2]
synonym: "ATP:creatine phosphotransferase activity" EXACT [EC:2.7.3.2]
synonym: "BB-CK" RELATED [EC:2.7.3.2]
synonym: "CK" RELATED [EC:2.7.3.2]
synonym: "CK-BB" RELATED [EC:2.7.3.2]
synonym: "CK-MB" RELATED [EC:2.7.3.2]
synonym: "CK-MM" RELATED [EC:2.7.3.2]
synonym: "CKMiMi" RELATED [EC:2.7.3.2]
synonym: "creatine phosphokinase activity" EXACT [EC:2.7.3.2]
synonym: "creatine phosphotransferase activity" EXACT [EC:2.7.3.2]
synonym: "MB-CK" RELATED [EC:2.7.3.2]
synonym: "Mi-CK" RELATED [EC:2.7.3.2]
synonym: "MiMi-CK" RELATED [EC:2.7.3.2]
synonym: "MM-CK" RELATED [EC:2.7.3.2]
synonym: "phosphocreatine kinase activity" EXACT [EC:2.7.3.2]
xref: EC:2.7.3.2
xref: KEGG:R01881
xref: MetaCyc:CREATINE-KINASE-RXN
xref: Reactome:REACT_100539 "creatine + ATP => phosphocreatine + ADP [CK octamer], Gallus gallus"
xref: Reactome:REACT_101438 "creatine + ATP => phosphocreatine + ADP [CKB,CKM], Rattus norvegicus"
xref: Reactome:REACT_105411 "creatine + ATP => phosphocreatine + ADP [CKB,CKM], Xenopus tropicalis"
xref: Reactome:REACT_108499 "creatine + ATP => phosphocreatine + ADP [CK octamer], Xenopus tropicalis"
xref: Reactome:REACT_109981 "creatine + ATP => phosphocreatine + ADP [CKB,CKM], Bos taurus"
xref: Reactome:REACT_110682 "creatine + ATP => phosphocreatine + ADP [CKB,CKM], Gallus gallus"
xref: Reactome:REACT_11155 "creatine + ATP => phosphocreatine + ADP [CK octamer], Homo sapiens"
xref: Reactome:REACT_11156 "creatine + ATP => phosphocreatine + ADP [CKB,CKM], Homo sapiens"
xref: Reactome:REACT_111938 "creatine + ATP => phosphocreatine + ADP [CKB,CKM], Staphylococcus aureus N315"
xref: Reactome:REACT_112531 "creatine + ATP => phosphocreatine + ADP [CK octamer], Staphylococcus aureus N315"
xref: Reactome:REACT_113875 "creatine + ATP => phosphocreatine + ADP [CK octamer], Rattus norvegicus"
xref: Reactome:REACT_31867 "creatine + ATP => phosphocreatine + ADP [CK octamer], Canis familiaris"
xref: Reactome:REACT_32596 "creatine + ATP => phosphocreatine + ADP [CK octamer], Bos taurus"
xref: Reactome:REACT_34284 "creatine + ATP => phosphocreatine + ADP [CK octamer], Sus scrofa"
xref: Reactome:REACT_84876 "creatine + ATP => phosphocreatine + ADP [CK octamer], Taeniopygia guttata"
xref: Reactome:REACT_87789 "creatine + ATP => phosphocreatine + ADP [CKB,CKM], Taeniopygia guttata"
xref: Reactome:REACT_90123 "creatine + ATP => phosphocreatine + ADP [CK octamer], Mus musculus"
xref: Reactome:REACT_94681 "creatine + ATP => phosphocreatine + ADP [CKB,CKM], Canis familiaris"
xref: Reactome:REACT_94782 "creatine + ATP => phosphocreatine + ADP [CKB,CKM], Danio rerio"
xref: Reactome:REACT_96287 "creatine + ATP => phosphocreatine + ADP [CK octamer], Danio rerio"
xref: Reactome:REACT_99155 "creatine + ATP => phosphocreatine + ADP [CKB,CKM], Mus musculus"
xref: RHEA:17160
is_a: GO:0016301 ! kinase activity
is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor

[Term]
id: GO:0004112
name: cyclic-nucleotide phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate." [GOC:mah]
subset: gosubset_prok
xref: EC:3.1.4.-
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0004113
name: 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate." [EC:3.1.4.37]
subset: gosubset_prok
synonym: "2',3'-cyclic AMP phosphodiesterase activity" EXACT [EC:3.1.4.37]
synonym: "2',3'-cyclic nucleoside monophosphate phosphodiesterase" BROAD [EC:3.1.4.37]
synonym: "2',3'-cyclic nucleotide 3'-phosphodiesterase activity" EXACT []
synonym: "2',3'-cyclic nucleotide 3'-phosphohydrolase activity" EXACT [EC:3.1.4.37]
synonym: "2',3'-cyclic nucleotide phosphohydrolase" BROAD [EC:3.1.4.37]
synonym: "2':3'-CNMP-3'-ase activity" EXACT [EC:3.1.4.37]
synonym: "2':3'-cyclic nucleotide 3'-phosphodiesterase activity" EXACT [EC:3.1.4.37]
synonym: "CNPase activity" EXACT [EC:3.1.4.37]
synonym: "cyclic 2',3'-nucleotide 3'-phosphodiesterase activity" EXACT [EC:3.1.4.37]
synonym: "cyclic 2',3'-nucleotide phosphodiesterase" BROAD [EC:3.1.4.37]
synonym: "cyclic-CMP phosphodiesterase activity" NARROW [EC:3.1.4.37]
synonym: "nucleoside-2',3'-cyclic-phosphate 2'-nucleotidohydrolase activity" EXACT [EC:3.1.4.37]
xref: EC:3.1.4.37
xref: MetaCyc:3.1.4.37-RXN
is_a: GO:0004112 ! cyclic-nucleotide phosphodiesterase activity

[Term]
id: GO:0004114
name: 3',5'-cyclic-nucleotide phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate." [EC:3.1.4.17]
subset: gosubset_prok
synonym: "3', 5'-cyclic nucleoside monophosphate phosphodiesterase activity" EXACT [EC:3.1.4.17]
synonym: "3',5' cyclic-nucleotide phosphodiesterase activity" EXACT []
synonym: "3',5'-cyclic-nucleotide 5'-nucleotidohydrolase activity" EXACT [EC:3.1.4.17]
synonym: "3',5'-cyclonucleotide phosphodiesterase activity" EXACT [EC:3.1.4.17]
synonym: "3',5'-nucleotide phosphodiesterase activity" EXACT [EC:3.1.4.17]
synonym: "3': 5'-monophosphate phosphodiesterase (cyclic CMP) activity" EXACT [EC:3.1.4.17]
synonym: "3':5'-cyclic nucleotide 5'-nucleotidohydrolase activity" EXACT [EC:3.1.4.17]
synonym: "cyclic 3',5'-mononucleotide phosphodiesterase activity" EXACT [EC:3.1.4.17]
synonym: "cyclic 3',5'-nucleotide phosphodiesterase activity" EXACT [EC:3.1.4.17]
synonym: "cyclic 3',5'-phosphodiesterase activity" EXACT [EC:3.1.4.17]
synonym: "cyclic 3',5-nucleotide monophosphate phosphodiesterase activity" EXACT [EC:3.1.4.17]
synonym: "cyclic AMP phosphodiesterase activity" NARROW [EC:3.1.4.17]
synonym: "cyclic nucleotide phosphodiesterase activity" EXACT [EC:3.1.4.17]
synonym: "cytidine 3':5'-monophosphate phosphodiesterase (cyclic CMP) activity" EXACT [EC:3.1.4.17]
synonym: "nucleoside 3',5'-cyclic phosphate diesterase activity" EXACT [EC:3.1.4.17]
synonym: "nucleoside-3',5-monophosphate phosphodiesterase activity" EXACT [EC:3.1.4.17]
synonym: "PDE" RELATED [EC:3.1.4.17]
xref: EC:3.1.4.17
xref: MetaCyc:3.1.4.17-RXN
xref: Reactome:REACT_105099 "Hydrolysis of cAMP to 5' AMP by Phosphorylated PDE3B, Taeniopygia guttata"
xref: Reactome:REACT_106371 "Hydrolysis of cAMP to 5' AMP by Phosphorylated PDE3B, Canis familiaris"
xref: Reactome:REACT_109851 "Hydrolysis of cAMP to 5' AMP by Phosphorylated PDE3B, Caenorhabditis elegans"
xref: Reactome:REACT_114232 "Hydrolysis of cAMP to 5' AMP by Phosphorylated PDE3B, Plasmodium falciparum"
xref: Reactome:REACT_28964 "Hydrolysis of cAMP to 5' AMP by Phosphorylated PDE3B, Mus musculus"
xref: Reactome:REACT_325 "Hydrolysis of cAMP to 5' AMP by Phosphorylated PDE3B, Homo sapiens"
xref: Reactome:REACT_80740 "Hydrolysis of cAMP to 5' AMP by Phosphorylated PDE3B, Rattus norvegicus"
xref: Reactome:REACT_82008 "Hydrolysis of cAMP to 5' AMP by Phosphorylated PDE3B, Sus scrofa"
xref: Reactome:REACT_83917 "Hydrolysis of cAMP to 5' AMP by Phosphorylated PDE3B, Bos taurus"
xref: Reactome:REACT_91190 "Hydrolysis of cAMP to 5' AMP by Phosphorylated PDE3B, Gallus gallus"
xref: Reactome:REACT_98934 "Hydrolysis of cAMP to 5' AMP by Phosphorylated PDE3B, Xenopus tropicalis"
xref: Reactome:REACT_99156 "Hydrolysis of cAMP to 5' AMP by Phosphorylated PDE3B, Danio rerio"
xref: RHEA:14656
is_a: GO:0004112 ! cyclic-nucleotide phosphodiesterase activity

[Term]
id: GO:0004115
name: 3',5'-cyclic-AMP phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate." [GOC:ai]
subset: gosubset_prok
synonym: "3',5' cAMP-specific phosphodiesterase activity" EXACT []
synonym: "3',5'-cAMP-specific phosphodiesterase activity" EXACT []
synonym: "3',5'-cyclic-AMP-specific phosphodiesterase activity" EXACT []
synonym: "adenosine 3',5'-cyclophosphate-specific phosphodiesterase activity" EXACT []
synonym: "cAMP-specific phosphodiesterase activity" EXACT []
synonym: "cyclic AMP-specific phosphodiesterase activity" EXACT []
xref: EC:3.1.4.-
xref: MetaCyc:RXN0-5038
xref: Reactome:REACT_103170 "cAMP hydrolysis by PDE 4, Sus scrofa"
xref: Reactome:REACT_104009 "cAMP degradation by Phosphodiesterases, Mus musculus"
xref: Reactome:REACT_109814 "cAMP degradation by Phosphodiesterases, Sus scrofa"
xref: Reactome:REACT_110463 "cAMP hydrolysis by PDE 4, Gallus gallus"
xref: Reactome:REACT_112238 "cAMP hydrolysis by PDE 4, Dictyostelium discoideum"
xref: Reactome:REACT_115186 "cAMP hydrolysis by PDE 4, Plasmodium falciparum"
xref: Reactome:REACT_1257 "cAMP hydrolysis by PDE 4, Homo sapiens"
xref: Reactome:REACT_19387 "cAMP degradation by Phosphodiesterases, Homo sapiens"
xref: Reactome:REACT_30870 "cAMP hydrolysis by PDE 4, Xenopus tropicalis"
xref: Reactome:REACT_31083 "cAMP hydrolysis by PDE 4, Taeniopygia guttata"
xref: Reactome:REACT_31890 "cAMP degradation by Phosphodiesterases, Gallus gallus"
xref: Reactome:REACT_33515 "cAMP hydrolysis by PDE 4, Caenorhabditis elegans"
xref: Reactome:REACT_33747 "cAMP degradation by Phosphodiesterases, Drosophila melanogaster"
xref: Reactome:REACT_34147 "cAMP degradation by Phosphodiesterases, Rattus norvegicus"
xref: Reactome:REACT_34190 "cAMP hydrolysis by PDE 4, Mus musculus"
xref: Reactome:REACT_77308 "cAMP degradation by Phosphodiesterases, Plasmodium falciparum"
xref: Reactome:REACT_82598 "cAMP degradation by Phosphodiesterases, Caenorhabditis elegans"
xref: Reactome:REACT_85939 "cAMP hydrolysis by PDE 4, Rattus norvegicus"
xref: Reactome:REACT_86709 "cAMP hydrolysis by PDE 4, Bos taurus"
xref: Reactome:REACT_88948 "cAMP hydrolysis by PDE 4, Danio rerio"
xref: Reactome:REACT_89237 "cAMP hydrolysis by PDE 4, Drosophila melanogaster"
xref: Reactome:REACT_94229 "cAMP degradation by Phosphodiesterases, Dictyostelium discoideum"
xref: Reactome:REACT_96329 "cAMP degradation by Phosphodiesterases, Bos taurus"
xref: Reactome:REACT_96372 "cAMP degradation by Phosphodiesterases, Canis familiaris"
xref: Reactome:REACT_98400 "cAMP degradation by Phosphodiesterases, Danio rerio"
xref: Reactome:REACT_99458 "cAMP degradation by Phosphodiesterases, Xenopus tropicalis"
xref: Reactome:REACT_99647 "cAMP hydrolysis by PDE 4, Canis familiaris"
xref: Reactome:REACT_99851 "cAMP degradation by Phosphodiesterases, Taeniopygia guttata"
is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity

[Term]
id: GO:0004117
name: calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is regulated by calmodulin." [GOC:mah]
xref: EC:3.1.4.-
xref: Reactome:REACT_100660 "cAMP hydrolysis by Cam-PDE 1, Xenopus tropicalis"
xref: Reactome:REACT_102161 "cAMP hydrolysis by Cam-PDE 1, Taeniopygia guttata"
xref: Reactome:REACT_104978 "cAMP hydrolysis by Cam-PDE 1, Bos taurus"
xref: Reactome:REACT_105407 "cAMP hydrolysis by Cam-PDE 1, Rattus norvegicus"
xref: Reactome:REACT_105998 "cAMP hydrolysis by Cam-PDE 1, Canis familiaris"
xref: Reactome:REACT_114149 "cAMP hydrolysis by Cam-PDE 1, Dictyostelium discoideum"
xref: Reactome:REACT_114485 "cAMP hydrolysis by Cam-PDE 1, Plasmodium falciparum"
xref: Reactome:REACT_28755 "cAMP hydrolysis by Cam-PDE 1, Drosophila melanogaster"
xref: Reactome:REACT_33765 "cAMP hydrolysis by Cam-PDE 1, Danio rerio"
xref: Reactome:REACT_82138 "cAMP hydrolysis by Cam-PDE 1, Sus scrofa"
xref: Reactome:REACT_827 "cAMP hydrolysis by Cam-PDE 1, Homo sapiens"
xref: Reactome:REACT_83188 "cAMP hydrolysis by Cam-PDE 1, Mus musculus"
xref: Reactome:REACT_83224 "cAMP hydrolysis by Cam-PDE 1, Caenorhabditis elegans"
xref: Reactome:REACT_85278 "cAMP hydrolysis by Cam-PDE 1, Gallus gallus"
is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity

[Term]
id: GO:0004118
name: cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is increased in the presence of cGMP." [GOC:mah]
xref: EC:3.1.4.-
is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity

[Term]
id: GO:0004119
name: cGMP-inhibited cyclic-nucleotide phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is decreased in the presence of cGMP." [GOC:mah]
xref: EC:3.1.4.-
is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity

[Term]
id: GO:0004120
name: photoreceptor cyclic-nucleotide phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside cyclic phosphate + H2O = nucleoside phosphate. This reaction is the hydrolysis of bonds in a cyclic nucleotide." [EC:3.1.4.-]
xref: EC:3.1.4.-
is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity

[Term]
id: GO:0004121
name: cystathionine beta-lyase activity
namespace: molecular_function
alt_id: GO:0008799
def: "Catalysis of the reaction: cystathionine + H2O = L-homocysteine + NH3 + pyruvate." [EC:4.4.1.8]
subset: gosubset_prok
synonym: "beta C-S lyase activity" EXACT [EC:4.4.1.8]
synonym: "beta-cystathionase activity" EXACT [EC:4.4.1.8]
synonym: "cystathionine L-homocysteine-lyase (deaminating)" EXACT [EC:4.4.1.8]
synonym: "cystine lyase activity" EXACT [EC:4.4.1.8]
synonym: "L-cystathionine L-homocysteine-lyase (deaminating)" EXACT [EC:4.4.1.8]
synonym: "L-cystathionine L-homocysteine-lyase (deaminating; pyruvate-forming)" EXACT [EC:4.4.1.8]
xref: EC:4.4.1.8
xref: MetaCyc:CYSTATHIONINE-BETA-LYASE-RXN
xref: RHEA:13968
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0004122
name: cystathionine beta-synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-serine + L-homocysteine = cystathionine + H2O." [EC:4.2.1.22]
subset: gosubset_prok
synonym: "beta-thionase activity" EXACT [EC:4.2.1.22]
synonym: "L-serine hydro-lyase (adding homocysteine)" EXACT [EC:4.2.1.22]
synonym: "L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" EXACT [EC:4.2.1.22]
synonym: "methylcysteine synthase activity" EXACT [EC:4.2.1.22]
synonym: "serine sulfhydrase activity" EXACT [EC:4.2.1.22]
synonym: "serine sulfhydrylase activity" EXACT [EC:4.2.1.22]
xref: EC:4.2.1.22
xref: MetaCyc:CYSTATHIONINE-BETA-SYNTHASE-RXN
xref: Reactome:REACT_115874 "Cystathionine is formed from homocysteine and serine, Homo sapiens"
xref: RHEA:10115
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0004123
name: cystathionine gamma-lyase activity
namespace: molecular_function
alt_id: GO:0016225
def: "Catalysis of the reaction: L-cystathionine + H2O = 2-oxobutanoate + L-cysteine + NH4+." [RHEA:24918]
synonym: "gamma-cystathionase activity" BROAD [EC:4.4.1.1]
synonym: "homoserine deaminase activity" RELATED [EC:4.4.1.1]
synonym: "homoserine deaminase-cystathionase activity" RELATED [EC:4.4.1.1]
synonym: "homoserine dehydratase activity" RELATED [EC:4.4.1.1]
synonym: "L-cystathionine cysteine-lyase (deaminating)" BROAD [EC:4.4.1.1]
synonym: "L-cystathionine cysteine-lyase (deaminating; 2-oxobutanoate-forming)" EXACT [EC:4.4.1.1]
xref: EC:4.4.1.1
xref: KEGG:R01001
xref: MetaCyc:CYSTAGLY-RXN
xref: Reactome:REACT_116098 "Cleavage of cystathionine into cysteine, Homo sapiens"
xref: Reactome:REACT_27170 "Cysteine from cystathionine and vice versa, Mycobacterium tuberculosis"
xref: RHEA:24918
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0004124
name: cysteine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: O3-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate." [EC:4.2.99.8]
comment: Note that this function was formerly 4.2.99.8.
subset: gosubset_prok
synonym: "3-O-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase activity" EXACT [EC:2.5.1.47]
synonym: "acetylserine sulfhydrylase activity" EXACT [EC:2.5.1.47]
synonym: "cysteine synthetase activity" EXACT [EC:2.5.1.47]
synonym: "O(3)-acetyl-L-serine acetate-lyase (adding hydrogen-sulfide) activity" EXACT [EC:2.5.1.47]
synonym: "O-acetyl-L-serine sulfhydrylase activity" EXACT [EC:2.5.1.47]
synonym: "O-acetyl-L-serine sulfohydrolase activity" EXACT [EC:2.5.1.47]
synonym: "O-acetylserine (thiol)-lyase A activity" NARROW [EC:2.5.1.47]
synonym: "O-acetylserine (thiol)-lyase activity" EXACT [EC:2.5.1.47]
synonym: "O-acetylserine sulfhydrylase activity" EXACT [EC:2.5.1.47]
synonym: "O3-acetyl-L-serine acetate-lyase (adding hydrogen-sulfide)" EXACT [EC:2.5.1.47]
synonym: "O3-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase activity" EXACT [EC:2.5.1.47]
synonym: "OAS sulfhydrylase activity" EXACT [EC:2.5.1.47]
xref: EC:2.5.1.47
xref: MetaCyc:ACSERLY-RXN
xref: Reactome:REACT_27172 "deacetylation of O-acetylserine and sulfhydrylation using CysK2, Mycobacterium tuberculosis"
xref: Reactome:REACT_27282 "deacetylation of O-acetylserine and sulfhydrylation using CysK1, Mycobacterium tuberculosis"
xref: RHEA:14832
is_a: GO:0016835 ! carbon-oxygen lyase activity
relationship: part_of GO:0019344 ! cysteine biosynthetic process

[Term]
id: GO:0004125
name: L-seryl-tRNASec selenium transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + H2O + phosphate." [EC:2.9.1.1]
subset: gosubset_prok
synonym: "cysteinyl-tRNA(Sec)-selenium transferase activity" EXACT [EC:2.9.1.1]
synonym: "cysteinyl-tRNA(Sel)-selenium transferase activity" EXACT [EC:2.9.1.1]
synonym: "cysteinyl-tRNA(Ser) selenium transferase activity" EXACT []
synonym: "cysteinyl-tRNASec-selenium transferase activity" EXACT [EC:2.9.1.1]
synonym: "cysteinyl-tRNASel-selenium transferase activity" EXACT [EC:2.9.1.1]
synonym: "L-selenocysteinyl-tRNA(Sec) synthase activity" EXACT [EC:2.9.1.1]
synonym: "L-selenocysteinyl-tRNA(Sel) synthase activity" EXACT [EC:2.9.1.1]
synonym: "L-selenocysteinyl-tRNASec synthase activity" EXACT [EC:2.9.1.1]
synonym: "L-selenocysteinyl-tRNASel synthase activity" EXACT [EC:2.9.1.1]
synonym: "L-seryl-tRNA(Ser) selenium transferase activity" EXACT []
synonym: "selenocysteine synthase activity" EXACT []
synonym: "selenocysteinyl-tRNA(Ser) synthase activity" EXACT []
synonym: "selenophosphate:L-seryl-tRNASec selenium transferase activity" EXACT [EC:2.9.1.1]
xref: EC:2.9.1.1
xref: MetaCyc:2.9.1.1-RXN
is_a: GO:0016785 ! transferase activity, transferring selenium-containing groups

[Term]
id: GO:0004126
name: cytidine deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: cytidine + H2O = uridine + NH3." [EC:3.5.4.5]
subset: gosubset_prok
synonym: "cytidine aminohydrolase activity" EXACT [EC:3.5.4.5]
synonym: "cytosine nucleoside deaminase activity" EXACT [EC:3.5.4.5]
xref: EC:3.5.4.5
xref: MetaCyc:CYTIDEAM2-RXN
xref: Reactome:REACT_100555 "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ [CDA], Schizosaccharomyces pombe"
xref: Reactome:REACT_102821 "C4 deamination of cytidine, Taeniopygia guttata"
xref: Reactome:REACT_103670 "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ [CDA], Drosophila melanogaster"
xref: Reactome:REACT_104831 "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ [CDA], Saccharomyces cerevisiae"
xref: Reactome:REACT_105043 "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ [CDA], Mus musculus"
xref: Reactome:REACT_106971 "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ [CDA], Gallus gallus"
xref: Reactome:REACT_107871 "C4 deamination of cytidine, Mus musculus"
xref: Reactome:REACT_108941 "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ [CDA], Rattus norvegicus"
xref: Reactome:REACT_30951 "C4 deamination of cytidine, Canis familiaris"
xref: Reactome:REACT_376 "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ [CDA], Homo sapiens"
xref: Reactome:REACT_80189 "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ [CDA], Bos taurus"
xref: Reactome:REACT_81775 "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ [CDA], Dictyostelium discoideum"
xref: Reactome:REACT_86483 "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ [CDA], Mycobacterium tuberculosis"
xref: Reactome:REACT_86734 "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ [CDA], Sus scrofa"
xref: Reactome:REACT_869 "C4 deamination of cytidine, Homo sapiens"
xref: Reactome:REACT_89154 "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ [CDA], Taeniopygia guttata"
xref: Reactome:REACT_91892 "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ [CDA], Caenorhabditis elegans"
xref: Reactome:REACT_92525 "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ [CDA], Canis familiaris"
xref: Reactome:REACT_92541 "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ [CDA], Staphylococcus aureus N315"
xref: Reactome:REACT_92713 "C4 deamination of cytidine, Rattus norvegicus"
xref: Reactome:REACT_94503 "C4 deamination of cytidine, Bos taurus"
xref: Reactome:REACT_94636 "C4 deamination of cytidine, Sus scrofa"
xref: Reactome:REACT_94708 "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ [CDA], Danio rerio"
xref: RHEA:16072
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity
relationship: part_of GO:0009972 ! cytidine deamination

[Term]
id: GO:0004127
name: cytidylate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + (d)CMP = ADP + (d)CDP." [EC:2.7.4.14]
subset: gosubset_prok
synonym: "ATP:CMP phosphotransferase activity" EXACT [EC:2.7.4.14]
synonym: "ATP:UMP-CMP phosphotransferase activity" EXACT [EC:2.7.4.14]
synonym: "CMP kinase activity" NARROW [EC:2.7.4.14]
synonym: "CTP:CMP phosphotransferase activity" EXACT [EC:2.7.4.14]
synonym: "cytidine monophosphate kinase activity" EXACT [EC:2.7.4.14]
synonym: "dCMP kinase activity" NARROW [EC:2.7.4.14]
synonym: "deoxycytidine monophosphokinase activity" EXACT [EC:2.7.4.14]
synonym: "deoxycytidylate kinase activity" BROAD [EC:2.7.4.14]
synonym: "pyrimidine nucleoside monophosphate kinase activity" EXACT [EC:2.7.4.14]
synonym: "UMP-CMP kinase activity" EXACT [EC:2.7.4.14]
xref: EC:2.7.4.14
xref: MetaCyc:CMPKI-RXN
is_a: GO:0019201 ! nucleotide kinase activity

[Term]
id: GO:0004128
name: cytochrome-b5 reductase activity, acting on NAD(P)H
namespace: molecular_function
def: "Catalysis of the reaction: NAD(P)H + H+ + 2 ferricytochrome b(5) = NAD(P)+ + 2 ferrocytochrome b(5)." [EC:1.6.2.2, ISBN:0198547684]
synonym: "cytochrome b5 reductase activity" EXACT [EC:1.6.2.2]
synonym: "dihydronicotinamide adenine dinucleotide-cytochrome b5 reductase activity" EXACT [EC:1.6.2.2]
synonym: "NADH 5alpha-reductase activity" EXACT [EC:1.6.2.2]
synonym: "NADH-cytochrome b5 reductase activity" EXACT [EC:1.6.2.2]
synonym: "NADH-cytochrome-b5 reductase activity" EXACT [EC:1.6.2.2]
synonym: "NADH-ferricytochrome b5 oxidoreductase activity" EXACT [EC:1.6.2.2]
synonym: "NADH:ferricytochrome-b5 oxidoreductase activity" EXACT [EC:1.6.2.2]
synonym: "reduced nicotinamide adeninedinucleotide-cytochrome b5 reductase activity" EXACT [EC:1.6.2.2]
xref: EC:1.6.2.2
xref: MetaCyc:CYTOCHROME-B5-REDUCTASE-RXN
xref: Reactome:REACT_103424 "Reduction of ferric cytochrome B5A to ferrous cytochrome B5A, Gallus gallus"
xref: Reactome:REACT_104486 "Reduction of ferric cytochrome B5A to ferrous cytochrome B5A, Danio rerio"
xref: Reactome:REACT_11182 "Reduction of ferric cytochrome B5A to ferrous cytochrome B5A, Homo sapiens"
xref: Reactome:REACT_30308 "Reduction of ferric cytochrome B5A to ferrous cytochrome B5A, Mus musculus"
xref: Reactome:REACT_78517 "Reduction of ferric cytochrome B5A to ferrous cytochrome B5A, Sus scrofa"
xref: Reactome:REACT_79858 "Reduction of ferric cytochrome B5A to ferrous cytochrome B5A, Xenopus tropicalis"
xref: Reactome:REACT_85388 "Reduction of ferric cytochrome B5A to ferrous cytochrome B5A, Rattus norvegicus"
xref: Reactome:REACT_90736 "Reduction of ferric cytochrome B5A to ferrous cytochrome B5A, Bos taurus"
xref: Reactome:REACT_90791 "Reduction of ferric cytochrome B5A to ferrous cytochrome B5A, Canis familiaris"
xref: Reactome:REACT_95419 "Reduction of ferric cytochrome B5A to ferrous cytochrome B5A, Taeniopygia guttata"
is_a: GO:0016653 ! oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor

[Term]
id: GO:0004129
name: cytochrome-c oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1]
comment: The reduction of O2 to water is accompanied by the extrusion of four protons from the intramitochondrial compartment.
subset: gosubset_prok
synonym: "aa3-type cytochrome c oxidase" NARROW [EC:1.9.3.1]
synonym: "ba3-type cytochrome c oxidase" NARROW [EC:1.9.3.1]
synonym: "caa3-type cytochrome c oxidase" NARROW [EC:1.9.3.1]
synonym: "cbb3-type cytochrome c oxidase" NARROW [EC:1.9.3.1]
synonym: "complex IV (mitochondrial electron transport) activity" RELATED [EC:1.9.3.1]
synonym: "cytochrome a3 activity" NARROW [EC:1.9.3.1]
synonym: "cytochrome aa3 activity" NARROW [EC:1.9.3.1]
synonym: "cytochrome c oxidase activity" EXACT [GOC:tb]
synonym: "cytochrome oxidase activity" RELATED [EC:1.9.3.1]
synonym: "ferrocytochrome c oxidase" NARROW [EC:1.9.3.1]
synonym: "ferrocytochrome-c:oxygen oxidoreductase" NARROW [EC:1.9.3.1]
synonym: "indophenol oxidase" NARROW [EC:1.9.3.1]
synonym: "indophenolase" NARROW [EC:1.9.3.1]
synonym: "NADH cytochrome c oxidase" EXACT [EC:1.9.3.1]
synonym: "warburg's respiratory enzyme activity" RELATED [EC:1.9.3.1]
xref: EC:1.9.3.1
xref: MetaCyc:CYTOCHROME-C-OXIDASE-RXN
xref: Reactome:REACT_113276 "Electron transfer from reduced cytochrome c to molecular oxygen, Bos taurus"
xref: Reactome:REACT_113311 "Electron transfer from reduced cytochrome c to molecular oxygen, Sus scrofa"
xref: Reactome:REACT_113736 "Electron transfer from reduced cytochrome c to molecular oxygen, Canis familiaris"
xref: Reactome:REACT_115027 "Electron transfer from reduced cytochrome c to molecular oxygen, Rattus norvegicus"
xref: Reactome:REACT_33608 "Electron transfer from reduced cytochrome c to molecular oxygen, Danio rerio"
xref: Reactome:REACT_6149 "Electron transfer from reduced cytochrome c to molecular oxygen, Homo sapiens"
xref: Reactome:REACT_78871 "Electron transfer from reduced cytochrome c to molecular oxygen, Gallus gallus"
xref: Reactome:REACT_99789 "Electron transfer from reduced cytochrome c to molecular oxygen, Mus musculus"
is_a: GO:0009055 ! electron carrier activity
is_a: GO:0015002 ! heme-copper terminal oxidase activity
is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity
is_a: GO:0016676 ! oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor

[Term]
id: GO:0004130
name: cytochrome-c peroxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 ferrocytochrome c + hydrogen peroxide = 2 ferricytochrome c + 2 H2O." [EC:1.11.1.5]
subset: gosubset_prok
synonym: "apocytochrome c peroxidase activity" EXACT [EC:1.11.1.5]
synonym: "cytochrome c peroxidase activity" EXACT [EC:1.11.1.5]
synonym: "cytochrome c-551 peroxidase activity" EXACT [EC:1.11.1.5]
synonym: "cytochrome c-H2O oxidoreductase activity" EXACT [EC:1.11.1.5]
synonym: "cytochrome peroxidase activity" EXACT [EC:1.11.1.5]
synonym: "ferrocytochrome-c:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.5]
synonym: "mesocytochrome c peroxidase azide" RELATED [EC:1.11.1.5]
synonym: "mesocytochrome c peroxidase cyanate" RELATED [EC:1.11.1.5]
synonym: "mesocytochrome c peroxidase cyanide" RELATED [EC:1.11.1.5]
xref: EC:1.11.1.5
xref: MetaCyc:CYTOCHROME-C-PEROXIDASE-RXN
is_a: GO:0004601 ! peroxidase activity

[Term]
id: GO:0004131
name: cytosine deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: cytosine + H2O = uracil + NH3." [EC:3.5.4.1]
subset: gosubset_prok
synonym: "cytosine aminohydrolase activity" EXACT [EC:3.5.4.1]
synonym: "isocytosine deaminase activity" EXACT [EC:3.5.4.1]
xref: EC:3.5.4.1
xref: MetaCyc:CYTDEAM-RXN
xref: RHEA:20608
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0004132
name: dCMP deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: dCMP + H2O = dUMP + NH3." [EC:3.5.4.12]
subset: gosubset_prok
synonym: "dCMP aminohydrolase activity" EXACT [EC:3.5.4.12]
synonym: "deoxy-CMP-deaminase activity" EXACT [EC:3.5.4.12]
synonym: "deoxycytidine monophosphate deaminase activity" EXACT [EC:3.5.4.12]
synonym: "deoxycytidine-5'-monophosphate aminohydrolase activity" EXACT [EC:3.5.4.12]
synonym: "deoxycytidine-5'-phosphate deaminase activity" EXACT [EC:3.5.4.12]
synonym: "deoxycytidylate aminohydrolase activity" EXACT [EC:3.5.4.12]
synonym: "deoxycytidylate deaminase activity" EXACT [EC:3.5.4.12]
xref: EC:3.5.4.12
xref: MetaCyc:DCMP-DEAMINASE-RXN
xref: Reactome:REACT_101387 "dCMP + H2O => dUMP + NH4+, Canis familiaris"
xref: Reactome:REACT_102792 "dCMP + H2O => dUMP + NH4+, Arabidopsis thaliana"
xref: Reactome:REACT_105322 "dCMP + H2O => dUMP + NH4+, Danio rerio"
xref: Reactome:REACT_105695 "dCMP + H2O => dUMP + NH4+, Staphylococcus aureus N315"
xref: Reactome:REACT_106595 "dCMP + H2O => dUMP + NH4+, Oryza sativa"
xref: Reactome:REACT_110788 "dCMP + H2O => dUMP + NH4+, Rattus norvegicus"
xref: Reactome:REACT_30304 "dCMP + H2O => dUMP + NH4+, Saccharomyces cerevisiae"
xref: Reactome:REACT_31119 "dCMP + H2O => dUMP + NH4+, Schizosaccharomyces pombe"
xref: Reactome:REACT_33008 "dCMP + H2O => dUMP + NH4+, Sus scrofa"
xref: Reactome:REACT_34269 "dCMP + H2O => dUMP + NH4+, Taeniopygia guttata"
xref: Reactome:REACT_81043 "dCMP + H2O => dUMP + NH4+, Bos taurus"
xref: Reactome:REACT_82206 "dCMP + H2O => dUMP + NH4+, Mus musculus"
xref: Reactome:REACT_84263 "dCMP + H2O => dUMP + NH4+, Drosophila melanogaster"
xref: Reactome:REACT_879 "dCMP + H2O => dUMP + NH4+, Homo sapiens"
xref: Reactome:REACT_90963 "dCMP + H2O => dUMP + NH4+, Caenorhabditis elegans"
xref: Reactome:REACT_95511 "dCMP + H2O => dUMP + NH4+, Gallus gallus"
xref: Reactome:REACT_95855 "dCMP + H2O => dUMP + NH4+, Xenopus tropicalis"
xref: RHEA:22927
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0004133
name: glycogen debranching enzyme activity
namespace: molecular_function
def: "Catalysis of the cleavage of branch points in branched glycogen polymers." [ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0003824 ! catalytic activity
relationship: part_of GO:0005977 ! glycogen metabolic process

[Term]
id: GO:0004134
name: 4-alpha-glucanotransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1->4)-alpha-D-glucan." [EC:2.4.1.25]
subset: gosubset_prok
synonym: "1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase activity" EXACT [EC:2.4.1.25]
synonym: "amylomaltase activity" EXACT [EC:2.4.1.25]
synonym: "D-enzyme activity" RELATED [EC:2.4.1.25]
synonym: "debranching enzyme maltodextrin glycosyltransferase activity" EXACT [EC:2.4.1.25]
synonym: "dextrin glycosyltransferase activity" RELATED [EC:2.4.1.25]
synonym: "dextrin transglycosylase activity" EXACT [EC:2.4.1.25]
synonym: "disproportionating enzyme activity" RELATED [EC:2.4.1.25]
synonym: "oligo-1,4-1,4-glucantransferase activity" EXACT [EC:2.4.1.25]
xref: EC:2.4.1.25
xref: MetaCyc:AMYLOMALT-RXN
xref: MetaCyc:RXN-1828
xref: MetaCyc:RXN-9023
xref: Reactome:REACT_102056 "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin, Xenopus tropicalis"
xref: Reactome:REACT_1507 "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin, Homo sapiens"
xref: Reactome:REACT_29429 "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin, Danio rerio"
xref: Reactome:REACT_29453 "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin, Caenorhabditis elegans"
xref: Reactome:REACT_31073 "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin, Canis familiaris"
xref: Reactome:REACT_32827 "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin, Saccharomyces cerevisiae"
xref: Reactome:REACT_34234 "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin, Gallus gallus"
xref: Reactome:REACT_80055 "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin, Sus scrofa"
xref: Reactome:REACT_82649 "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin, Bos taurus"
xref: Reactome:REACT_83752 "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin, Rattus norvegicus"
xref: Reactome:REACT_88252 "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin, Mus musculus"
xref: Reactome:REACT_88797 "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin, Taeniopygia guttata"
is_a: GO:0004133 ! glycogen debranching enzyme activity
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0004135
name: amylo-alpha-1,6-glucosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin. Limit dextrin is the highly branched core that remains after exhaustive treatment of glycogen with glycogen phosphorylase. It is formed because these enzymes cannot hydrolyze the (1->6) glycosidic linkages present." [EC:3.2.1.33, ISBN:0198506732]
subset: gosubset_prok
synonym: "amylo-1,6-glucosidase activity" EXACT []
synonym: "amylopectin 1,6-glucosidase activity" EXACT [EC:3.2.1.33]
synonym: "dextrin 6-alpha-D-glucosidase activity" RELATED [EC:3.2.1.33]
synonym: "dextrin-1,6-glucosidase activity" EXACT [EC:3.2.1.33]
synonym: "glycogen phosphorylase-limit dextrin alpha-1,6-glucohydrolase activity" EXACT [EC:3.2.1.33]
xref: EC:3.2.1.33
xref: MetaCyc:3.2.1.33-RXN
xref: Reactome:REACT_106625 "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose, Caenorhabditis elegans"
xref: Reactome:REACT_108579 "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose, Saccharomyces cerevisiae"
xref: Reactome:REACT_108658 "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose, Sus scrofa"
xref: Reactome:REACT_1433 "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose, Homo sapiens"
xref: Reactome:REACT_79503 "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose, Canis familiaris"
xref: Reactome:REACT_83785 "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose, Rattus norvegicus"
xref: Reactome:REACT_84618 "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose, Bos taurus"
xref: Reactome:REACT_88815 "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose, Xenopus tropicalis"
xref: Reactome:REACT_90121 "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose, Gallus gallus"
xref: Reactome:REACT_93342 "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose, Mus musculus"
xref: Reactome:REACT_95109 "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose, Taeniopygia guttata"
xref: Reactome:REACT_97615 "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose, Danio rerio"
is_a: GO:0004133 ! glycogen debranching enzyme activity
is_a: GO:0090599 ! alpha-glucosidase activity

[Term]
id: GO:0004136
name: deoxyadenosine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2'-deoxyadenosine + ATP = ADP + dAMP + 2 H(+)." [EC:2.7.1.76, RHEA:23455]
subset: gosubset_prok
synonym: "ATP:deoxyadenosine 5'-phosphotransferase activity" EXACT [EC:2.7.1.76]
synonym: "deoxyadenosine kinase (phosphorylating)" EXACT [EC:2.7.1.76]
synonym: "purine-deoxyribonucleoside kinase activity" EXACT [EC:2.7.1.76]
xref: EC:2.7.1.76
xref: KEGG:R02089
xref: MetaCyc:DEOXYADENOSINE-KINASE-RXN
xref: RHEA:23455
is_a: GO:0019136 ! deoxynucleoside kinase activity
relationship: part_of GO:0006170 ! dAMP biosynthetic process

[Term]
id: GO:0004137
name: deoxycytidine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: NTP + deoxycytidine = NDP + CMP." [EC:2.7.1.74]
subset: gosubset_prok
synonym: "2'-deoxycytidine kinase activity" EXACT [EC:2.7.1.74]
synonym: "Ara-C kinase activity" EXACT [EC:2.7.1.74]
synonym: "arabinofuranosylcytosine kinase activity" EXACT [EC:2.7.1.74]
synonym: "deoxycytidine kinase (phosphorylating)" EXACT [EC:2.7.1.74]
synonym: "deoxycytidine-cytidine kinase activity" EXACT [EC:2.7.1.74]
synonym: "NTP:deoxycytidine 5'-phosphotransferase activity" EXACT [EC:2.7.1.74]
xref: EC:2.7.1.74
xref: MetaCyc:DEOXYCYTIDINE-KINASE-RXN
xref: RHEA:20064
is_a: GO:0019136 ! deoxynucleoside kinase activity

[Term]
id: GO:0004138
name: deoxyguanosine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2'-deoxyguanosine + ATP = ADP + dGMP + 2 H(+)." [EC:2.7.1.113, RHEA:19204]
subset: gosubset_prok
synonym: "(dihydroxypropoxymethyl)guanine kinase activity" EXACT [EC:2.7.1.113]
synonym: "2'-deoxyguanosine kinase activity" EXACT [EC:2.7.1.113]
synonym: "ATP:deoxyguanosine 5'-phosphotransferase activity" EXACT [EC:2.7.1.113]
synonym: "deoxyguanosine kinase (phosphorylating)" EXACT [EC:2.7.1.113]
synonym: "NTP-deoxyguanosine 5'-phosphotransferase activity" EXACT [EC:2.7.1.113]
xref: EC:2.7.1.113
xref: KEGG:R01967
xref: MetaCyc:DEOXYGUANOSINE-KINASE-RXN
xref: RHEA:19204
is_a: GO:0019136 ! deoxynucleoside kinase activity

[Term]
id: GO:0004139
name: deoxyribose-phosphate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde." [EC:4.1.2.4, RHEA:12824]
subset: gosubset_prok
synonym: "2-deoxy-D-ribose-5-phosphate acetaldehyde-lyase (D-glyceraldehyde-3-phosphate-forming)" EXACT [EC:4.1.2.4]
synonym: "2-deoxy-D-ribose-5-phosphate acetaldehyde-lyase activity" EXACT [EC:4.1.2.4]
synonym: "2-deoxyribose-5-phosphate aldolase activity" EXACT [EC:4.1.2.4]
synonym: "deoxyriboaldolase activity" RELATED [EC:4.1.2.4]
synonym: "deoxyribose-5-phosphate aldolase activity" EXACT [EC:4.1.2.4]
synonym: "phosphodeoxyriboaldolase activity" EXACT [EC:4.1.2.4]
xref: EC:4.1.2.4
xref: KEGG:R01066
xref: MetaCyc:DEOXYRIBOSE-P-ALD-RXN
xref: RHEA:12824
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0004140
name: dephospho-CoA kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-dephospho-CoA + ATP = ADP + CoA + 2 H(+)." [EC:2.7.1.24, RHEA:18248]
subset: gosubset_prok
synonym: "3'-dephospho-CoA kinase activity" EXACT [EC:2.7.1.24]
synonym: "ATP:dephospho-CoA 3'-phosphotransferase activity" EXACT [EC:2.7.1.24]
synonym: "dephosphocoenzyme A kinase (phosphorylating)" EXACT [EC:2.7.1.24]
synonym: "dephosphocoenzyme A kinase activity" RELATED [EC:2.7.1.24]
xref: EC:2.7.1.24
xref: KEGG:R00130
xref: MetaCyc:DEPHOSPHOCOAKIN-RXN
xref: Reactome:REACT_102484 "Phosphorylation of dephospho-CoA to produce CoA, Dictyostelium discoideum"
xref: Reactome:REACT_110357 "Phosphorylation of dephospho-CoA to produce CoA, Escherichia coli"
xref: Reactome:REACT_11093 "Phosphorylation of dephospho-CoA to produce CoA, Homo sapiens"
xref: Reactome:REACT_112662 "Phosphorylation of dephospho-CoA to produce CoA, Plasmodium falciparum"
xref: Reactome:REACT_30468 "Phosphorylation of dephospho-CoA to produce CoA, Xenopus tropicalis"
xref: Reactome:REACT_30902 "Phosphorylation of dephospho-CoA to produce CoA, Canis familiaris"
xref: Reactome:REACT_32306 "Phosphorylation of dephospho-CoA to produce CoA, Drosophila melanogaster"
xref: Reactome:REACT_33500 "Phosphorylation of dephospho-CoA to produce CoA, Sus scrofa"
xref: Reactome:REACT_82321 "Phosphorylation of dephospho-CoA to produce CoA, Danio rerio"
xref: Reactome:REACT_89804 "Phosphorylation of dephospho-CoA to produce CoA, Rattus norvegicus"
xref: Reactome:REACT_90005 "Phosphorylation of dephospho-CoA to produce CoA, Caenorhabditis elegans"
xref: Reactome:REACT_93983 "Phosphorylation of dephospho-CoA to produce CoA, Taeniopygia guttata"
xref: Reactome:REACT_99187 "Phosphorylation of dephospho-CoA to produce CoA, Mus musculus"
xref: RHEA:18248
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0004141
name: dethiobiotin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7,8-diaminononanoate + ATP + CO(2) = ADP + dethiobiotin + 4 H(+) + phosphate." [EC:6.3.3.3, RHEA:15808]
subset: gosubset_prok
synonym: "7,8-diaminononanoate:carbon-dioxide cyclo-ligase (ADP-forming)" EXACT [EC:6.3.3.3]
synonym: "desthiobiotin synthase activity" EXACT [EC:6.3.3.3]
synonym: "DTB synthetase activity" EXACT [EC:6.3.3.3]
xref: EC:6.3.3.3
xref: KEGG:R03182
xref: MetaCyc:DETHIOBIOTIN-SYN-RXN
xref: RHEA:15808
is_a: GO:0016882 ! cyclo-ligase activity

[Term]
id: GO:0004142
name: diacylglycerol cholinephosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CDP-choline + 1,2-diacylglycerol = CMP + a phosphatidylcholine." [EC:2.7.8.2]
synonym: "1-alkyl-2-acetyl-m-glycerol:CDPcholine choline phosphotransferase activity" EXACT [EC:2.7.8.2]
synonym: "1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase activity" EXACT [EC:2.7.8.2]
synonym: "1-alkyl-2-acetylglycerol cholinephosphotransferase activity" EXACT [EC:2.7.8.2]
synonym: "alkylacylglycerol choline phosphotransferase activity" EXACT [EC:2.7.8.2]
synonym: "alkylacylglycerol cholinephosphotransferase activity" EXACT [EC:2.7.8.2]
synonym: "CDP-choline diglyceride phosphotransferase activity" EXACT [EC:2.7.8.2]
synonym: "CDP-choline:1,2-diacylglycerol cholinephosphotransferase activity" EXACT [EC:2.7.8.2]
synonym: "cholinephosphotransferase activity" RELATED [EC:2.7.8.2]
synonym: "CPT" RELATED [EC:2.7.8.2]
synonym: "cytidine diphosphocholine glyceride transferase activity" EXACT [EC:2.7.8.2]
synonym: "cytidine diphosphorylcholine diglyceride transferase activity" EXACT [EC:2.7.8.2]
synonym: "diacylglycerol choline phosphotransferase activity" EXACT [EC:2.7.8.2]
synonym: "phosphocholine diacylglyceroltransferase activity" EXACT [EC:2.7.8.2]
synonym: "phosphorylcholine--glyceride transferase activity" EXACT [EC:2.7.8.2]
synonym: "sn-1,2-diacylglycerol cholinephosphotransferase activity" EXACT [EC:2.7.8.2]
xref: EC:2.7.8.2
xref: MetaCyc:RXN-5781
xref: RHEA:10311
is_a: GO:0017169 ! CDP-alcohol phosphatidyltransferase activity
relationship: part_of GO:0006657 ! CDP-choline pathway

[Term]
id: GO:0004143
name: diacylglycerol kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate." [EC:2.7.1.107, GOC:elh]
subset: gosubset_prok
synonym: "1,2-diacylglycerol kinase (phosphorylating)" EXACT [EC:2.7.1.107]
synonym: "1,2-diacylglycerol kinase activity" EXACT [EC:2.7.1.107]
synonym: "arachidonoyl-specific diacylglycerol kinase activity" EXACT [EC:2.7.1.107]
synonym: "ATP:1,2-diacylglycerol 3-phosphotransferase activity" NARROW [EC:2.7.1.107]
synonym: "ATP:diacylglycerol phosphotransferase activity" NARROW [EC:2.7.1.107]
synonym: "CTP:diacylglycerol kinase activity" NARROW []
synonym: "DG kinase activity" EXACT [EC:2.7.1.107]
synonym: "DGK activity" EXACT [EC:2.7.1.107]
synonym: "diacylglycerol:ATP kinase activity" NARROW [EC:2.7.1.107]
synonym: "diglyceride kinase activity" EXACT [EC:2.7.1.107]
synonym: "sn-1,2-diacylglycerol kinase activity" EXACT [EC:2.7.1.107]
xref: EC:2.7.1.107
xref: MetaCyc:DIACYLGLYKIN-RXN
xref: Reactome:REACT_100005 "DAG kinase produces phosphatidic acid from DAG, Sus scrofa"
xref: Reactome:REACT_101911 "DAG kinase produces phosphatidic acid from DAG, Drosophila melanogaster"
xref: Reactome:REACT_107713 "DAG kinase produces phosphatidic acid from DAG, Gallus gallus"
xref: Reactome:REACT_109578 "DAG kinase produces phosphatidic acid from DAG, Plasmodium falciparum"
xref: Reactome:REACT_109644 "DAG kinase produces phosphatidic acid from DAG, Canis familiaris"
xref: Reactome:REACT_109845 "DAG kinase produces phosphatidic acid from DAG, Xenopus tropicalis"
xref: Reactome:REACT_19402 "DAG kinase produces phosphatidic acid from DAG, Homo sapiens"
xref: Reactome:REACT_78206 "DAG kinase produces phosphatidic acid from DAG, Mus musculus"
xref: Reactome:REACT_79070 "DAG kinase produces phosphatidic acid from DAG, Rattus norvegicus"
xref: Reactome:REACT_93530 "DAG kinase produces phosphatidic acid from DAG, Oryza sativa"
xref: Reactome:REACT_95006 "DAG kinase produces phosphatidic acid from DAG, Bos taurus"
xref: Reactome:REACT_99113 "DAG kinase produces phosphatidic acid from DAG, Arabidopsis thaliana"
xref: Reactome:REACT_99297 "DAG kinase produces phosphatidic acid from DAG, Taeniopygia guttata"
xref: Reactome:REACT_99856 "DAG kinase produces phosphatidic acid from DAG, Caenorhabditis elegans"
xref: Reactome:REACT_99935 "DAG kinase produces phosphatidic acid from DAG, Danio rerio"
xref: RHEA:10275
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0004144
name: diacylglycerol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol." [EC:2.3.1.20]
subset: gosubset_prok
synonym: "1,2-diacylglycerol acyltransferase activity" EXACT [EC:2.3.1.20]
synonym: "acyl-CoA:1,2-diacylglycerol O-acyltransferase activity" EXACT [EC:2.3.1.20]
synonym: "diacylglycerol acyltransferase activity" EXACT [EC:2.3.1.20]
synonym: "diglyceride acyltransferase activity" EXACT [EC:2.3.1.20]
synonym: "diglyceride O-acyltransferase activity" EXACT [EC:2.3.1.20]
synonym: "palmitoyl-CoA-sn-1,2-diacylglycerol acyltransferase activity" EXACT [EC:2.3.1.20]
xref: EC:2.3.1.20
xref: MetaCyc:DIACYLGLYCEROL-O-ACYLTRANSFERASE-RXN
xref: Reactome:REACT_100155 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1], Rattus norvegicus"
xref: Reactome:REACT_103886 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2], Taeniopygia guttata"
xref: Reactome:REACT_104139 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1], Sus scrofa"
xref: Reactome:REACT_104875 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1], Mus musculus"
xref: Reactome:REACT_110678 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1], Xenopus tropicalis"
xref: Reactome:REACT_112540 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2], Arabidopsis thaliana"
xref: Reactome:REACT_112715 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2], Schizosaccharomyces pombe"
xref: Reactome:REACT_114635 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2], Oryza sativa"
xref: Reactome:REACT_22179 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2], Homo sapiens"
xref: Reactome:REACT_28123 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1], Plasmodium falciparum"
xref: Reactome:REACT_28392 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2], Sus scrofa"
xref: Reactome:REACT_31769 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2], Rattus norvegicus"
xref: Reactome:REACT_32550 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1], Drosophila melanogaster"
xref: Reactome:REACT_659 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1], Homo sapiens"
xref: Reactome:REACT_77149 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1], Oryza sativa"
xref: Reactome:REACT_77431 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1], Canis familiaris"
xref: Reactome:REACT_81790 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2], Bos taurus"
xref: Reactome:REACT_88501 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1], Caenorhabditis elegans"
xref: Reactome:REACT_89294 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1], Danio rerio"
xref: Reactome:REACT_89429 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2], Canis familiaris"
xref: Reactome:REACT_92156 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2], Dictyostelium discoideum"
xref: Reactome:REACT_92925 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2], Gallus gallus"
xref: Reactome:REACT_93842 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2], Xenopus tropicalis"
xref: Reactome:REACT_95845 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1], Bos taurus"
xref: Reactome:REACT_96341 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2], Mus musculus"
xref: Reactome:REACT_98065 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1], Arabidopsis thaliana"
xref: Reactome:REACT_98763 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2], Saccharomyces cerevisiae"
xref: Reactome:REACT_99469 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2], Danio rerio"
xref: Reactome:REACT_99733 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1], Dictyostelium discoideum"
xref: RHEA:10871
is_a: GO:0016411 ! acylglycerol O-acyltransferase activity

[Term]
id: GO:0004145
name: diamine N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine." [EC:2.3.1.57]
subset: gosubset_prok
synonym: "acetyl-CoA:alkane-alpha,omega-diamine N-acetyltransferase activity" EXACT [EC:2.3.1.57]
synonym: "acetyl-coenzyme A-1,4-diaminobutane N-acetyltransferase activity" NARROW []
synonym: "diamine acetyltransferase activity" EXACT []
synonym: "putrescine (diamine)-acetylating enzyme activity" NARROW []
synonym: "putrescine acetylase activity" NARROW [EC:2.3.1.57]
synonym: "putrescine acetyltransferase activity" NARROW [EC:2.3.1.57]
synonym: "putrescine N-acetyltransferase activity" NARROW [EC:2.3.1.57]
synonym: "spermidine acetyltransferase activity" NARROW [EC:2.3.1.57]
synonym: "spermidine N(1)-acetyltransferase activity" NARROW [EC:2.3.1.57]
synonym: "spermidine N1-acetyltransferase activity" EXACT [EC:2.3.1.57]
synonym: "spermidine/spermine N1-acetyltransferase activity" EXACT [EC:2.3.1.57]
synonym: "spermine acetyltransferase" NARROW []
synonym: "spermine N(1)-acetyltransferase" NARROW []
synonym: "spermine N-acetyltransferase" RELATED []
xref: EC:2.3.1.57
xref: MetaCyc:DIAMACTRANS-RXN
xref: Reactome:REACT_102979 "Spermine => N-acetylated spermine, Sus scrofa"
xref: Reactome:REACT_103903 "Spermine => N-acetylated spermine, Danio rerio"
xref: Reactome:REACT_106439 "Spermine => N-acetylated spermine, Xenopus tropicalis"
xref: Reactome:REACT_106602 "Spermine => N-acetylated spermine, Oryza sativa"
xref: Reactome:REACT_108255 "Spermine => N-acetylated spermine, Mus musculus"
xref: Reactome:REACT_108956 "Spermidine => N-acetylated spermidine, Schizosaccharomyces pombe"
xref: Reactome:REACT_14811 "Spermine => N-acetylated spermine, Homo sapiens"
xref: Reactome:REACT_14817 "Spermidine => N-acetylated spermidine, Homo sapiens"
xref: Reactome:REACT_29565 "Spermine => N-acetylated spermine, Arabidopsis thaliana"
xref: Reactome:REACT_31206 "Spermidine => N-acetylated spermidine, Danio rerio"
xref: Reactome:REACT_31654 "Spermine => N-acetylated spermine, Gallus gallus"
xref: Reactome:REACT_32986 "Spermidine => N-acetylated spermidine, Bos taurus"
xref: Reactome:REACT_33438 "Spermidine => N-acetylated spermidine, Caenorhabditis elegans"
xref: Reactome:REACT_78089 "Spermidine => N-acetylated spermidine, Mycobacterium tuberculosis"
xref: Reactome:REACT_79405 "Spermine => N-acetylated spermine, Canis familiaris"
xref: Reactome:REACT_80061 "Spermine => N-acetylated spermine, Drosophila melanogaster"
xref: Reactome:REACT_81463 "Spermidine => N-acetylated spermidine, Xenopus tropicalis"
xref: Reactome:REACT_81666 "Spermine => N-acetylated spermine, Dictyostelium discoideum"
xref: Reactome:REACT_82051 "Spermine => N-acetylated spermine, Taeniopygia guttata"
xref: Reactome:REACT_85748 "Spermidine => N-acetylated spermidine, Gallus gallus"
xref: Reactome:REACT_85868 "Spermine => N-acetylated spermine, Bos taurus"
xref: Reactome:REACT_86359 "Spermine => N-acetylated spermine, Caenorhabditis elegans"
xref: Reactome:REACT_86990 "Spermidine => N-acetylated spermidine, Taeniopygia guttata"
xref: Reactome:REACT_90627 "Spermidine => N-acetylated spermidine, Canis familiaris"
xref: Reactome:REACT_91691 "Spermine => N-acetylated spermine, Rattus norvegicus"
xref: Reactome:REACT_92415 "Spermine => N-acetylated spermine, Schizosaccharomyces pombe"
xref: Reactome:REACT_92789 "Spermidine => N-acetylated spermidine, Rattus norvegicus"
xref: Reactome:REACT_93269 "Spermidine => N-acetylated spermidine, Mus musculus"
xref: Reactome:REACT_95402 "Spermine => N-acetylated spermine, Mycobacterium tuberculosis"
xref: Reactome:REACT_95517 "Spermidine => N-acetylated spermidine, Drosophila melanogaster"
xref: Reactome:REACT_96189 "Spermidine => N-acetylated spermidine, Sus scrofa"
xref: Reactome:REACT_96567 "Spermidine => N-acetylated spermidine, Dictyostelium discoideum"
xref: Reactome:REACT_97328 "Spermidine => N-acetylated spermidine, Oryza sativa"
xref: Reactome:REACT_99684 "Spermidine => N-acetylated spermidine, Arabidopsis thaliana"
xref: RHEA:25184
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0004146
name: dihydrofolate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+." [EC:1.5.1.3]
subset: gosubset_prok
synonym: "5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.3]
synonym: "7,8-dihydrofolate reductase activity" EXACT [EC:1.5.1.3]
synonym: "DHFR" RELATED [EC:1.5.1.3]
synonym: "dihydrofolate reductase:thymidylate synthase activity" EXACT [EC:1.5.1.3]
synonym: "dihydrofolate reduction" EXACT []
synonym: "dihydrofolic acid reductase activity" EXACT [EC:1.5.1.3]
synonym: "dihydrofolic reductase activity" EXACT [EC:1.5.1.3]
synonym: "folic acid reductase activity" EXACT [EC:1.5.1.3]
synonym: "folic reductase activity" EXACT [EC:1.5.1.3]
synonym: "NADPH-dihydrofolate reductase activity" EXACT [EC:1.5.1.3]
synonym: "pteridine reductase:dihydrofolate reductase activity" EXACT [EC:1.5.1.3]
synonym: "tetrahydrofolate dehydrogenase activity" EXACT [EC:1.5.1.3]
synonym: "thymidylate synthetase-dihydrofolate reductase activity" EXACT [EC:1.5.1.3]
xref: EC:1.5.1.3
xref: MetaCyc:DIHYDROFOLATEREDUCT-RXN
xref: Reactome:REACT_111041 "Salvage - BH2 is reduced to BH4 by DHFR, Homo sapiens"
xref: Reactome:REACT_115762 "Salvage - BH2 is reduced to BH4 by Dhfr, Mus musculus"
xref: RHEA:15012
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004147
name: dihydrolipoamide branched chain acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + dihydrolipoamide = CoA + S-acyldihydrolipoamide, where the acyl group is a branched chain." [GOC:mah]
subset: gosubset_prok
synonym: "dihydrolipoamide branched chain transacylase activity" EXACT []
xref: EC:2.3.1.-
is_a: GO:0030523 ! dihydrolipoamide S-acyltransferase activity

[Term]
id: GO:0004148
name: dihydrolipoyl dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+." [EC:1.8.1.4]
subset: gosubset_prok
synonym: "dehydrolipoate dehydrogenase activity" EXACT [EC:1.8.1.4]
synonym: "diaphorase activity" EXACT [EC:1.8.1.4]
synonym: "dihydrolipoamide dehydrogenase activity" EXACT [EC:1.8.1.4]
synonym: "dihydrolipoamide reduction" RELATED [EC:1.8.1.4]
synonym: "dihydrolipoamide:NAD+ oxidoreductase" EXACT [EC:1.8.1.4]
synonym: "dihydrolipoic dehydrogenase activity" EXACT [EC:1.8.1.4]
synonym: "dihydrolipoylprotein reduction" RELATED [EC:1.8.1.4]
synonym: "dihydrothioctic dehydrogenase activity" EXACT [EC:1.8.1.4]
synonym: "E3 component of alpha-ketoacid dehydrogenase complexes activity" RELATED [EC:1.8.1.4]
synonym: "glycine-cleavage system L-protein activity" RELATED [EC:1.8.1.4]
synonym: "L-protein activity" RELATED [EC:1.8.1.4]
synonym: "LDP-Glc activity" NARROW [EC:1.8.1.4]
synonym: "LDP-Val activity" NARROW [EC:1.8.1.4]
synonym: "lipoamide dehydrogenase (NADH) activity" EXACT [EC:1.8.1.4]
synonym: "lipoamide oxidoreductase (NADH) activity" EXACT [EC:1.8.1.4]
synonym: "lipoamide reductase (NADH) activity" EXACT [EC:1.8.1.4]
synonym: "lipoamide reductase activity" EXACT [EC:1.8.1.4]
synonym: "lipoate dehydrogenase activity" EXACT [EC:1.8.1.4]
synonym: "lipoic acid dehydrogenase activity" EXACT [EC:1.8.1.4]
synonym: "lipoyl dehydrogenase activity" EXACT [EC:1.8.1.4]
synonym: "protein-6-N-(dihydrolipoyl)lysine:NAD+ oxidoreductase" EXACT [EC:1.8.1.4]
synonym: "protein-N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase" EXACT [EC:1.8.1.4]
xref: EC:1.8.1.4
xref: MetaCyc:DIHYDLIPOXN-RXN
xref: RHEA:15048
is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor

[Term]
id: GO:0004149
name: dihydrolipoyllysine-residue succinyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: succinyl-CoA + dihydrolipoamide = CoA + S-succinyldihydrolipoamide." [EC:2.3.1.61]
subset: gosubset_prok
synonym: "dihydrolipoamide S-succinyltransferase activity" EXACT []
synonym: "dihydrolipoamide succinyltransferase activity" EXACT [EC:2.3.1.61]
synonym: "dihydrolipoic transsuccinylase activity" EXACT [EC:2.3.1.61]
synonym: "dihydrolipolyl transsuccinylase activity" EXACT [EC:2.3.1.61]
synonym: "dihydrolipoyl transsuccinylase activity" EXACT [EC:2.3.1.61]
synonym: "enzyme-dihydrolipoyllysine:succinyl-CoA S-succinyltransferase activity" EXACT [EC:2.3.1.61]
synonym: "lipoate succinyltransferase (Escherichia coli) activity" EXACT [EC:2.3.1.61]
synonym: "lipoate succinyltransferase activity" EXACT [EC:2.3.1.61]
synonym: "lipoic transsuccinylase activity" EXACT [EC:2.3.1.61]
synonym: "lipoyl transsuccinylase activity" EXACT [EC:2.3.1.61]
synonym: "succinyl-CoA:dihydrolipoamide S-succinyltransferase activity" EXACT [EC:2.3.1.61]
synonym: "succinyl-CoA:dihydrolipoate S-succinyltransferase activity" EXACT [EC:2.3.1.61]
synonym: "succinyl-CoA:enzyme-6-N-(dihydrolipoyl)lysine S-succinyltransferase activity" EXACT [EC:2.3.1.61]
synonym: "succinyl-CoA:enzyme-N6-(dihydrolipoyl)lysine S-succinyltransferase activity" EXACT [EC:2.3.1.61]
xref: EC:2.3.1.61
is_a: GO:0016751 ! S-succinyltransferase activity

[Term]
id: GO:0004150
name: dihydroneopterin aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde." [EC:4.1.2.25]
subset: gosubset_prok
synonym: "2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine glycolaldehyde-lyase (2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-forming)" EXACT [EC:4.1.2.25]
synonym: "2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine glycolaldehyde-lyase activity" EXACT [EC:4.1.2.25]
xref: EC:4.1.2.25
xref: MetaCyc:H2NEOPTERINALDOL-RXN
xref: RHEA:10543
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0004151
name: dihydroorotase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-dihydroorotate + H(2)O = N-carbamoyl-L-aspartate + H(+)." [EC:3.5.2.3, RHEA:24299]
subset: gosubset_prok
synonym: "(S)-dihydroorotate amidohydrolase activity" EXACT [EC:3.5.2.3]
synonym: "carbamoylaspartic dehydrase activity" EXACT [EC:3.5.2.3]
synonym: "DHOase activity" EXACT [EC:3.5.2.3]
synonym: "dihydroorotate hydrolase activity" EXACT [EC:3.5.2.3]
xref: EC:3.5.2.3
xref: KEGG:R01993
xref: MetaCyc:DIHYDROOROT-RXN
xref: Reactome:REACT_100968 "N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O, Mus musculus"
xref: Reactome:REACT_103707 "N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O, Schizosaccharomyces pombe"
xref: Reactome:REACT_104176 "N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O, Saccharomyces cerevisiae"
xref: Reactome:REACT_107004 "N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O, Plasmodium falciparum"
xref: Reactome:REACT_109520 "N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O, Danio rerio"
xref: Reactome:REACT_115876 "N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O, Gallus gallus"
xref: Reactome:REACT_30522 "N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O, Bos taurus"
xref: Reactome:REACT_32485 "N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O, Drosophila melanogaster"
xref: Reactome:REACT_32516 "N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O, Dictyostelium discoideum"
xref: Reactome:REACT_33026 "N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O, Caenorhabditis elegans"
xref: Reactome:REACT_744 "N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O, Homo sapiens"
xref: Reactome:REACT_78664 "N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O, Taeniopygia guttata"
xref: Reactome:REACT_80045 "N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O, Rattus norvegicus"
xref: Reactome:REACT_89075 "N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O, Canis familiaris"
xref: Reactome:REACT_99796 "N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O, Staphylococcus aureus N315"
xref: RHEA:24299
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0004152
name: dihydroorotate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-dihydroorotate + A = AH(2) + orotate." [EC:1.3.5.2, RHEA:18076]
subset: gosubset_prok
synonym: "(DHO) dehydrogenase activity" RELATED [EC:1.3.5.2]
synonym: "(S)-dihydroorotate:quinone oxidoreductase activity" EXACT systematic_synonym [EC:1.3.5.2]
synonym: "DHOdehase activity" EXACT [EC:1.3.5.2]
synonym: "dihydoorotic acid dehydrogenase activity" EXACT [EC:1.3.5.2]
synonym: "dihydroorotate:ubiquinone oxidoreductase activity" NARROW [EC:1.3.5.2]
xref: EC:1.3.5.2
xref: KEGG:R01868
xref: MetaCyc:DIHYDROOROTATE-DEHYDROGENASE-RXN
xref: Reactome:REACT_100074 "(S)-dihydroorotate + ubiquinone => orotate + ubiquinol, Rattus norvegicus"
xref: Reactome:REACT_101561 "(S)-dihydroorotate + ubiquinone => orotate + ubiquinol, Arabidopsis thaliana"
xref: Reactome:REACT_104099 "(S)-dihydroorotate + ubiquinone => orotate + ubiquinol, Caenorhabditis elegans"
xref: Reactome:REACT_105823 "(S)-dihydroorotate + ubiquinone => orotate + ubiquinol, Plasmodium falciparum"
xref: Reactome:REACT_106035 "(S)-dihydroorotate + ubiquinone => orotate + ubiquinol, Danio rerio"
xref: Reactome:REACT_109840 "(S)-dihydroorotate + ubiquinone => orotate + ubiquinol, Sus scrofa"
xref: Reactome:REACT_116075 "(S)-dihydroorotate + ubiquinone => orotate + ubiquinol, Gallus gallus"
xref: Reactome:REACT_32121 "(S)-dihydroorotate + ubiquinone => orotate + ubiquinol, Staphylococcus aureus N315"
xref: Reactome:REACT_32336 "(S)-dihydroorotate + ubiquinone => orotate + ubiquinol, Saccharomyces cerevisiae"
xref: Reactome:REACT_32754 "(S)-dihydroorotate + ubiquinone => orotate + ubiquinol, Xenopus tropicalis"
xref: Reactome:REACT_34767 "(S)-dihydroorotate + ubiquinone => orotate + ubiquinol, Taeniopygia guttata"
xref: Reactome:REACT_669 "(S)-dihydroorotate + ubiquinone => orotate + ubiquinol, Homo sapiens"
xref: Reactome:REACT_77905 "(S)-dihydroorotate + ubiquinone => orotate + ubiquinol, Oryza sativa"
xref: Reactome:REACT_79091 "(S)-dihydroorotate + ubiquinone => orotate + ubiquinol, Gallus gallus"
xref: Reactome:REACT_82404 "(S)-dihydroorotate + ubiquinone => orotate + ubiquinol, Schizosaccharomyces pombe"
xref: Reactome:REACT_87685 "(S)-dihydroorotate + ubiquinone => orotate + ubiquinol, Escherichia coli"
xref: Reactome:REACT_89913 "(S)-dihydroorotate + ubiquinone => orotate + ubiquinol, Drosophila melanogaster"
xref: Reactome:REACT_90116 "(S)-dihydroorotate + ubiquinone => orotate + ubiquinol, Canis familiaris"
xref: Reactome:REACT_96217 "(S)-dihydroorotate + ubiquinone => orotate + ubiquinol, Bos taurus"
xref: Reactome:REACT_98035 "(S)-dihydroorotate + ubiquinone => orotate + ubiquinol, Mus musculus"
xref: Reactome:REACT_99640 "(S)-dihydroorotate + ubiquinone => orotate + ubiquinol, Mycobacterium tuberculosis"
xref: RHEA:18076
is_a: GO:0016635 ! oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor

[Term]
id: GO:0004153
name: dihydropterin deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7,8-dihydropterin + H2O = 7,8-dihydrolumazine + NH3." [FB:FBrf0039640, GOC:jl, http://www.abbs.info/fulltxt/eng/35030306.htm, ISSN:05829879]
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0004154
name: dihydropterin oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 7,8-dihydropteridine + O2 = a pterin + hydrogen peroxide." [GOC:mah, PMID:1745247, PMID:6815189]
xref: EC:1.5.3.-
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0004155
name: 6,7-dihydropteridine reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + 5,6,7,8-tetrahydropteridine = NADPH + H+ + 6,7-dihydropteridine." [EC:1.5.1.34]
comment: Note that this function was formerly EC:1.6.99.7.
subset: gosubset_prok
synonym: "5,6,7,8-tetrahydropteridine:NAD(P)+ oxidoreductase activity" EXACT [EC:1.5.1.34]
synonym: "5,6,7,8-tetrahydropteridine:NAD(P)H+ oxidoreductase activity" EXACT [EC:1.5.1.34]
synonym: "6,7-dihydropteridine:NAD(P)H oxidoreductase activity" EXACT [EC:1.5.1.34]
synonym: "DHPR activity" EXACT [EC:1.5.1.34]
synonym: "dihydropteridine (reduced nicotinamide adenine dinucleotide) reductase activity" EXACT [EC:1.5.1.34]
synonym: "dihydropteridine reductase (NADH) activity" EXACT [EC:1.5.1.34]
synonym: "dihydropteridine reductase activity" EXACT []
synonym: "dihydropteridine reduction" RELATED []
synonym: "NAD(P)H(2):6,7-dihydropteridine oxidoreductase activity" EXACT [EC:1.5.1.34]
synonym: "NAD(P)H2:6,7-dihydropteridine oxidoreductase activity" EXACT [EC:1.5.1.34]
synonym: "NADH-dihydropteridine reductase activity" EXACT [EC:1.5.1.34]
synonym: "NADPH-dihydropteridine reductase activity" EXACT [EC:1.5.1.34]
synonym: "NADPH-specific dihydropteridine reductase activity" EXACT [EC:1.5.1.34]
xref: EC:1.5.1.34
xref: MetaCyc:1.5.1.34-RXN
xref: Reactome:REACT_101242 "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+, Rattus norvegicus"
xref: Reactome:REACT_101276 "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+, Gallus gallus"
xref: Reactome:REACT_1925 "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+, Homo sapiens"
xref: Reactome:REACT_29183 "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+, Mus musculus"
xref: Reactome:REACT_30563 "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+, Dictyostelium discoideum"
xref: Reactome:REACT_33125 "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+, Xenopus tropicalis"
xref: Reactome:REACT_33238 "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+, Drosophila melanogaster"
xref: Reactome:REACT_87568 "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+, Bos taurus"
xref: Reactome:REACT_92488 "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+, Canis familiaris"
xref: Reactome:REACT_92901 "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+, Caenorhabditis elegans"
xref: Reactome:REACT_93858 "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+, Danio rerio"
xref: Reactome:REACT_94721 "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+, Taeniopygia guttata"
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004156
name: dihydropteroate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate." [EC:2.5.1.15]
subset: gosubset_prok
synonym: "(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase activity" EXACT [EC:2.5.1.15]
synonym: "2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase activity" EXACT [EC:2.5.1.15]
synonym: "7,8-dihydropteroate synthase activity" EXACT [EC:2.5.1.15]
synonym: "7,8-dihydropteroate synthetase activity" EXACT [EC:2.5.1.15]
synonym: "7,8-dihydropteroic acid synthetase activity" EXACT [EC:2.5.1.15]
synonym: "DHPS activity" EXACT [EC:2.5.1.15]
synonym: "dihydropteroate diphosphorylase activity" EXACT [EC:2.5.1.15]
synonym: "dihydropteroate pyrophosphorylase activity" EXACT [EC:2.5.1.15]
synonym: "dihydropteroate synthetase activity" EXACT [EC:2.5.1.15]
synonym: "dihydropteroic synthetase activity" EXACT [EC:2.5.1.15]
xref: EC:2.5.1.15
xref: MetaCyc:H2PTEROATESYNTH-RXN
xref: RHEA:19952
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0004157
name: dihydropyrimidinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,6-dihydrouracil + H2O = 3-ureidopropionate." [EC:3.5.2.2]
subset: gosubset_prok
synonym: "5,6-dihydropyrimidine amidohydrolase activity" EXACT [EC:3.5.2.2]
synonym: "D-hydantoinase activity" EXACT [EC:3.5.2.2]
synonym: "hydantoin peptidase activity" EXACT [EC:3.5.2.2]
synonym: "hydantoinase activity" EXACT [EC:3.5.2.2]
synonym: "hydropyrimidine hydrase activity" EXACT [EC:3.5.2.2]
synonym: "pyrimidine hydrase activity" EXACT [EC:3.5.2.2]
xref: EC:3.5.2.2
xref: MetaCyc:DIHYDROPYRIMIDINASE-RXN
xref: Reactome:REACT_100830 "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate, Gallus gallus"
xref: Reactome:REACT_101446 "5,6-dihydrouracil + H2O => beta-ureidopropionate, Sus scrofa"
xref: Reactome:REACT_102809 "5,6-dihydrouracil + H2O => beta-ureidopropionate, Oryza sativa"
xref: Reactome:REACT_103556 "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate, Canis familiaris"
xref: Reactome:REACT_105429 "5,6-dihydrouracil + H2O => beta-ureidopropionate, Escherichia coli"
xref: Reactome:REACT_107309 "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate, Bos taurus"
xref: Reactome:REACT_107362 "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate, Sus scrofa"
xref: Reactome:REACT_108290 "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate, Xenopus tropicalis"
xref: Reactome:REACT_109169 "5,6-dihydrouracil + H2O => beta-ureidopropionate, Xenopus tropicalis"
xref: Reactome:REACT_113000 "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate, Drosophila melanogaster"
xref: Reactome:REACT_113669 "5,6-dihydrouracil + H2O => beta-ureidopropionate, Drosophila melanogaster"
xref: Reactome:REACT_1977 "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate, Homo sapiens"
xref: Reactome:REACT_2169 "5,6-dihydrouracil + H2O => beta-ureidopropionate, Homo sapiens"
xref: Reactome:REACT_29706 "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate, Taeniopygia guttata"
xref: Reactome:REACT_31178 "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate, Arabidopsis thaliana"
xref: Reactome:REACT_31256 "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate, Rattus norvegicus"
xref: Reactome:REACT_56207 "5,6-dihydrouracil + H2O => beta-ureidopropionate, Mus musculus"
xref: Reactome:REACT_81062 "5,6-dihydrouracil + H2O => beta-ureidopropionate, Gallus gallus"
xref: Reactome:REACT_82327 "5,6-dihydrouracil + H2O => beta-ureidopropionate, Rattus norvegicus"
xref: Reactome:REACT_82436 "5,6-dihydrouracil + H2O => beta-ureidopropionate, Dictyostelium discoideum"
xref: Reactome:REACT_85710 "5,6-dihydrouracil + H2O => beta-ureidopropionate, Taeniopygia guttata"
xref: Reactome:REACT_87087 "5,6-dihydrouracil + H2O => beta-ureidopropionate, Arabidopsis thaliana"
xref: Reactome:REACT_87711 "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate, Mus musculus"
xref: Reactome:REACT_89192 "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate, Danio rerio"
xref: Reactome:REACT_89935 "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate, Dictyostelium discoideum"
xref: Reactome:REACT_90336 "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate, Escherichia coli"
xref: Reactome:REACT_95295 "5,6-dihydrouracil + H2O => beta-ureidopropionate, Danio rerio"
xref: Reactome:REACT_95705 "5,6-dihydrouracil + H2O => beta-ureidopropionate, Bos taurus"
xref: Reactome:REACT_98259 "5,6-dihydrouracil + H2O => beta-ureidopropionate, Canis familiaris"
xref: Reactome:REACT_99864 "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate, Oryza sativa"
xref: RHEA:16124
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0004158
name: dihydroorotate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-dihydroorotate + O(2) = H(2)O(2) + orotate." [EC:1.3.3.1, RHEA:15444]
comment: This term represents a deleted EC activity and is scheduled for obsoletion.
subset: mf_needs_review
synonym: "(S)-dihydroorotate:oxygen oxidoreductase activity" EXACT [EC:1.3.3.1]
synonym: "4,5-L-dihydroorotate:oxygen oxidoreductase activity" EXACT [EC:1.3.3.1]
xref: EC:1.3.3.1
xref: RHEA:15444
is_a: GO:0004152 ! dihydroorotate dehydrogenase activity
is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor

[Term]
id: GO:0004159
name: dihydrouracil dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,6-dihydrouracil + NAD+ = uracil + NADH + H+." [EC:1.3.1.1]
synonym: "5,6-dihydrouracil:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.1]
synonym: "dehydrogenase, dihydrouracil" EXACT [EC:1.3.1.1]
synonym: "pyrimidine reductase activity" EXACT [EC:1.3.1.1]
synonym: "thymine reductase activity" EXACT [EC:1.3.1.1]
synonym: "uracil reductase activity" EXACT [EC:1.3.1.1]
xref: EC:1.3.1.1
xref: MetaCyc:DIHYDROURACIL-DEHYDROGENASE-NAD+-RXN
xref: RHEA:20192
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004160
name: dihydroxy-acid dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O." [EC:4.2.1.9]
subset: gosubset_prok
synonym: "2,3-dihydroxy-acid hydro-lyase (3-methyl-2-oxobutanoate-forming)" EXACT [EC:4.2.1.9]
synonym: "2,3-dihydroxy-acid hydro-lyase activity" EXACT [EC:4.2.1.9]
synonym: "2,3-dihydroxyisovalerate dehydratase activity" EXACT [EC:4.2.1.9]
synonym: "acetohydroxyacid dehydratase activity" EXACT [EC:4.2.1.9]
synonym: "alpha,beta-dihydroxyacid dehydratase activity" EXACT [EC:4.2.1.9]
synonym: "alpha,beta-dihydroxyisovalerate dehydratase activity" EXACT [EC:4.2.1.9]
synonym: "DHAD" RELATED [EC:4.2.1.9]
synonym: "dihydroxy acid dehydrase activity" EXACT [EC:4.2.1.9]
xref: EC:4.2.1.9
xref: MetaCyc:DIHYDROXYISOVALDEHYDRAT-RXN
xref: RHEA:20939
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0004161
name: dimethylallyltranstransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate." [EC:2.5.1.1]
comment: Note that this is the first step in the formation of farnesyl diphosphate. The second step is 'geranyltranstransferase activity ; GO:0004337'. Consider also annotating to the biological process term 'farnesyl diphosphate biosynthetic process ; GO:0045337'.
subset: gosubset_prok
synonym: "(2E,6E)-farnesyl diphosphate synthetase activity" EXACT [EC:2.5.1.1]
synonym: "dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallyltranstransferase activity" EXACT [EC:2.5.1.1]
synonym: "dimethylallyltransferase activity" EXACT []
synonym: "diprenyltransferase activity" EXACT [EC:2.5.1.1]
synonym: "DMAPP:IPP-dimethylallyltransferase activity" EXACT [EC:2.5.1.1]
synonym: "geranyl diphosphate synthase" EXACT []
synonym: "geranyl pyrophosphate synthase activity" EXACT [EC:2.5.1.1]
synonym: "geranyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.1]
synonym: "geranyl-diphosphate synthase activity" RELATED [EC:2.5.1.1]
synonym: "trans-farnesyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.1]
xref: EC:2.5.1.1
xref: MetaCyc:GPPSYN-RXN
xref: Reactome:REACT_100741 "Addition of isopentenyl pyrophosphate to DMAPP, Sus scrofa"
xref: Reactome:REACT_102050 "Addition of isopentenyl pyrophosphate to DMAPP, Oryza sativa"
xref: Reactome:REACT_102118 "Addition of isopentenyl pyrophosphate to DMAPP, Schizosaccharomyces pombe"
xref: Reactome:REACT_102935 "Addition of isopentenyl pyrophosphate to DMAPP, Arabidopsis thaliana"
xref: Reactome:REACT_103677 "Addition of isopentenyl pyrophosphate to DMAPP, Mus musculus"
xref: Reactome:REACT_104071 "Addition of isopentenyl pyrophosphate to DMAPP, Taeniopygia guttata"
xref: Reactome:REACT_107473 "Addition of isopentenyl pyrophosphate to DMAPP, Saccharomyces cerevisiae"
xref: Reactome:REACT_108928 "Addition of isopentenyl pyrophosphate to DMAPP, Gallus gallus"
xref: Reactome:REACT_109017 "Addition of isopentenyl pyrophosphate to DMAPP, Canis familiaris"
xref: Reactome:REACT_34263 "Addition of isopentenyl pyrophosphate to DMAPP, Xenopus tropicalis"
xref: Reactome:REACT_34609 "Addition of isopentenyl pyrophosphate to DMAPP, Caenorhabditis elegans"
xref: Reactome:REACT_79289 "Addition of isopentenyl pyrophosphate to DMAPP, Drosophila melanogaster"
xref: Reactome:REACT_87054 "Addition of isopentenyl pyrophosphate to DMAPP, Rattus norvegicus"
xref: Reactome:REACT_88460 "Addition of isopentenyl pyrophosphate to DMAPP, Danio rerio"
xref: Reactome:REACT_89249 "Addition of isopentenyl pyrophosphate to DMAPP, Plasmodium falciparum"
xref: Reactome:REACT_9467 "Addition of isopentenyl pyrophosphate to DMAPP, Homo sapiens"
xref: Reactome:REACT_96140 "Addition of isopentenyl pyrophosphate to DMAPP, Dictyostelium discoideum"
xref: Reactome:REACT_99636 "Addition of isopentenyl pyrophosphate to DMAPP, Bos taurus"
xref: RHEA:22411
is_a: GO:0004659 ! prenyltransferase activity

[Term]
id: GO:0004162
name: dimethylnitrosamine demethylase activity
namespace: molecular_function
def: "Catalysis of the removal of a methyl group from N-nitrosodimethylamine." [GOC:mah]
synonym: "N-nitrosodimethylamine demethylase activity" EXACT []
is_a: GO:0032451 ! demethylase activity

[Term]
id: GO:0004163
name: diphosphomevalonate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-5-diphosphomevalonate + ATP = ADP + CO(2) + H(+) + isopentenyl diphosphate + phosphate." [EC:4.1.1.33, RHEA:23735]
subset: gosubset_prok
synonym: "5-pyrophosphomevalonate decarboxylase activity" EXACT [EC:4.1.1.33]
synonym: "ATP:(R)-5-diphosphomevalonate carboxy-lyase (adding ATP; isopentenyl-diphosphate-forming)" EXACT [EC:4.1.1.33]
synonym: "ATP:(R)-5-diphosphomevalonate carboxy-lyase (dehydrating)" EXACT [EC:4.1.1.33]
synonym: "mevalonate 5-diphosphate decarboxylase activity" EXACT [EC:4.1.1.33]
synonym: "mevalonate diphosphate decarboxylase activity" EXACT [EC:4.1.1.33]
synonym: "mevalonate pyrophosphate decarboxylase activity" EXACT [EC:4.1.1.33]
synonym: "mevalonate-5-pyrophosphate decarboxylase activity" EXACT [EC:4.1.1.33]
synonym: "pyrophosphomevalonate decarboxylase activity" EXACT [EC:4.1.1.33]
synonym: "pyrophosphomevalonic acid decarboxylase activity" EXACT [EC:4.1.1.33]
xref: EC:4.1.1.33
xref: KEGG:R01121
xref: MetaCyc:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN
xref: Reactome:REACT_100521 "Mevalonate-5-pyrophosphate is decarboxylated, Dictyostelium discoideum"
xref: Reactome:REACT_101376 "Mevalonate-5-pyrophosphate is decarboxylated, Drosophila melanogaster"
xref: Reactome:REACT_102913 "Mevalonate-5-pyrophosphate is decarboxylated, Gallus gallus"
xref: Reactome:REACT_104999 "Mevalonate-5-pyrophosphate is decarboxylated, Xenopus tropicalis"
xref: Reactome:REACT_105125 "Mevalonate-5-pyrophosphate is decarboxylated, Mus musculus"
xref: Reactome:REACT_108444 "Mevalonate-5-pyrophosphate is decarboxylated, Rattus norvegicus"
xref: Reactome:REACT_109965 "Mevalonate-5-pyrophosphate is decarboxylated, Saccharomyces cerevisiae"
xref: Reactome:REACT_28129 "Mevalonate-5-pyrophosphate is decarboxylated, Canis familiaris"
xref: Reactome:REACT_33654 "Mevalonate-5-pyrophosphate is decarboxylated, Schizosaccharomyces pombe"
xref: Reactome:REACT_78028 "Mevalonate-5-pyrophosphate is decarboxylated, Danio rerio"
xref: Reactome:REACT_80726 "Mevalonate-5-pyrophosphate is decarboxylated, Oryza sativa"
xref: Reactome:REACT_81266 "Mevalonate-5-pyrophosphate is decarboxylated, Arabidopsis thaliana"
xref: Reactome:REACT_81926 "Mevalonate-5-pyrophosphate is decarboxylated, Staphylococcus aureus N315"
xref: Reactome:REACT_81997 "Mevalonate-5-pyrophosphate is decarboxylated, Caenorhabditis elegans"
xref: Reactome:REACT_92755 "Mevalonate-5-pyrophosphate is decarboxylated, Bos taurus"
xref: Reactome:REACT_9488 "Mevalonate-5-pyrophosphate is decarboxylated, Homo sapiens"
xref: Reactome:REACT_95775 "Mevalonate-5-pyrophosphate is decarboxylated, Taeniopygia guttata"
xref: RHEA:23735
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004164
name: diphthine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 2-(3-carboxy-3-aminopropyl)-L-histidine = S-adenosyl-L-homocysteine + 2-(3-carboxy-3-(methylammonio)propyl)-L-histidine." [EC:2.1.1.98]
subset: gosubset_prok
synonym: "diphthine methyltransferase activity" EXACT [EC:2.1.1.98]
synonym: "S-adenosyl-L-methionine:2-(3-carboxy-3-aminopropyl)-L-histidine methyltransferase activity" EXACT [EC:2.1.1.98]
synonym: "S-adenosyl-L-methionine:elongation factor 2 methyltransferase activity" EXACT [EC:2.1.1.98]
xref: EC:2.1.1.98
xref: MetaCyc:RXN-11370
xref: RHEA:20148
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0004165
name: dodecenoyl-CoA delta-isomerase activity
namespace: molecular_function
alt_id: GO:0008461
def: "Catalysis of the reaction: 3-cis-dodecenoyl-CoA = 2-trans-dodecenoyl-CoA." [EC:5.3.3.8]
subset: gosubset_prok
synonym: "3,2-trans-enoyl-CoA isomerase activity" EXACT [EC:5.3.3.8]
synonym: "acetylene-allene isomerase activity" EXACT [EC:5.3.3.8]
synonym: "delta(3),Delta(2)-enoyl-CoA isomerase activity" EXACT [EC:5.3.3.8]
synonym: "delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase activity" EXACT [EC:5.3.3.8]
synonym: "delta3,Delta2-enoyl-CoA isomerase activity" EXACT [EC:5.3.3.8]
synonym: "delta3-cis-delta2-trans-enoyl-CoA isomerase" BROAD [EC:5.3.3.8]
synonym: "dodecenoyl-CoA (3Z)-(2E)-isomerase activity" EXACT [EC:5.3.3.8]
synonym: "dodecenoyl-CoA D-isomerase activity" EXACT []
synonym: "dodecenoyl-CoA Delta-isomerase activity" EXACT [EC:5.3.3.8]
synonym: "dodecenoyl-CoA delta3-cis-delta2-trans-isomerase activity" EXACT [EC:5.3.3.8]
synonym: "dodecenoyl-CoA isomerase activity" EXACT [EC:5.3.3.8]
xref: EC:5.3.3.8
xref: MetaCyc:ENOYL-COA-DELTA-ISOM-RXN
xref: Reactome:REACT_104001 "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA, Canis familiaris"
xref: Reactome:REACT_28905 "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA, Drosophila melanogaster"
xref: Reactome:REACT_588 "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA, Homo sapiens"
xref: Reactome:REACT_78170 "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA, Xenopus tropicalis"
xref: Reactome:REACT_87434 "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA, Mycobacterium tuberculosis"
xref: Reactome:REACT_88442 "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA, Taeniopygia guttata"
xref: Reactome:REACT_88978 "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA, Danio rerio"
xref: Reactome:REACT_95247 "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA, Gallus gallus"
xref: Reactome:REACT_95915 "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA, Rattus norvegicus"
xref: Reactome:REACT_96247 "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA, Mus musculus"
xref: Reactome:REACT_98886 "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA, Bos taurus"
xref: RHEA:23719
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0004166
name: dolichyl-phosphate alpha-N-acetylglucosaminyltransferase activity
namespace: molecular_function
alt_id: GO:0004101
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UDP + dolichyl N-acetyl-alpha-D-glucosaminyl phosphate." [EC:2.4.1.153]
synonym: "dolichyl phosphate acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153]
synonym: "dolichyl phosphate N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153]
synonym: "dolichyl-phosphate acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153]
synonym: "dolichyl-phosphate N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153]
synonym: "UDP-N-acetyl-D-glucosamine:dolichyl-phosphate alpha-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.153]
synonym: "UDP-N-acetylglucosamine-dolichol phosphate N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153]
synonym: "uridine diphosphoacetylglucosamine-dolichol phosphate acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153]
xref: EC:2.4.1.153
xref: MetaCyc:2.4.1.153-RXN
xref: RHEA:14696
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0004167
name: dopachrome isomerase activity
namespace: molecular_function
alt_id: GO:0048059
def: "Catalysis of the reaction: L-dopachrome = 5,6-dihydroxyindole-2-carboxylate." [EC:5.3.3.12, RHEA:13044]
synonym: "DCF activity" EXACT [EC:5.3.3.12]
synonym: "DCT activity" EXACT [EC:5.3.3.12]
synonym: "dopachrome conversion activity" BROAD []
synonym: "dopachrome conversion factor activity" BROAD [EC:5.3.3.12]
synonym: "dopachrome Delta(7),Delta(2)-isomerase activity" EXACT [EC:5.3.3.12]
synonym: "dopachrome delta-isomerase activity" EXACT []
synonym: "dopachrome delta7,Delta2-isomerase activity" EXACT [EC:5.3.3.12]
synonym: "dopachrome keto-enol isomerase activity" EXACT [EC:5.3.3.12]
synonym: "dopachrome oxidoreductase activity" EXACT [EC:5.3.3.12]
synonym: "dopachrome rearranging enzyme activity" EXACT [EC:5.3.3.12]
synonym: "dopachrome tautomerase activity" EXACT [EC:5.3.3.12]
synonym: "dopachrome-rearranging enzyme" RELATED [EC:5.3.3.12]
synonym: "L-dopachrome isomerase activity" EXACT [EC:5.3.3.12]
synonym: "L-dopachrome keto-enol isomerase activity" EXACT [EC:5.3.3.12]
synonym: "L-dopachrome-methyl ester tautomerase activity" EXACT [EC:5.3.3.12]
synonym: "TRP activity" EXACT [EC:5.3.3.12]
synonym: "TRP-1" RELATED [EC:5.3.3.12]
synonym: "TRP-2" RELATED [EC:5.3.3.12]
synonym: "TRP2" RELATED [EC:5.3.3.12]
synonym: "tryosinase-related protein-2" RELATED [EC:5.3.3.12]
synonym: "tyrosinase-related protein 2 activity" EXACT [EC:5.3.3.12]
xref: EC:5.3.3.12
xref: KEGG:R03673
xref: MetaCyc:DOPACHROME-DELTA-ISOMERASE-RXN
xref: RHEA:13044
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0004168
name: dolichol kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: CTP + dolichol = CDP + dolichyl phosphate." [EC:2.7.1.108]
synonym: "CTP:dolichol O-phosphotransferase activity" EXACT [EC:2.7.1.108]
synonym: "dolichol phosphokinase activity" EXACT [EC:2.7.1.108]
xref: EC:2.7.1.108
xref: MetaCyc:DOLICHOL-KINASE-RXN
xref: Reactome:REACT_22276 "Phosphorylation of dolichol, Homo sapiens"
xref: RHEA:13136
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0004169
name: dolichyl-phosphate-mannose-protein mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein." [EC:2.4.1.109, GOC:pr]
comment: Note that this activity has never been observed in green plants. However, N- and C-mannosylation may occur in these species; see figure 1 in PMID:21558543.
subset: gosubset_prok
synonym: "dolichol phosphomannose-protein mannosyltransferase activity" EXACT [EC:2.4.1.109]
synonym: "dolichyl-phosphate-D-mannose:protein O-D-mannosyltransferase activity" EXACT [EC:2.4.1.109]
synonym: "dolichyl-phosphate-mannose-protein O-mannosyltransferase activity" EXACT []
synonym: "O-glycoside mannosyltransferase" BROAD []
synonym: "protein O-D-mannosyltransferase activity" EXACT [EC:2.4.1.109]
synonym: "protein O-mannosyltransferase activity" EXACT []
xref: EC:2.4.1.109
xref: MetaCyc:2.4.1.109-RXN
is_a: GO:0000030 ! mannosyltransferase activity
relationship: part_of GO:0035269 ! protein O-linked mannosylation

[Term]
id: GO:0004170
name: dUTP diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: dUTP + H2O = dUMP + diphosphate." [EC:3.6.1.23]
subset: goslim_chembl
subset: gosubset_prok
synonym: "deoxyuridine-triphosphatase activity" EXACT [EC:3.6.1.23]
synonym: "desoxyuridine 5'-triphosphatase activity" EXACT [EC:3.6.1.23]
synonym: "desoxyuridine 5'-triphosphate nucleotidohydrolase activity" EXACT [EC:3.6.1.23]
synonym: "dUTP nucleotidohydrolase activity" EXACT [EC:3.6.1.23]
synonym: "dUTP pyrophosphatase activity" EXACT []
synonym: "dUTPase activity" EXACT [EC:3.6.1.23]
xref: EC:3.6.1.23
xref: KEGG:R02100
xref: MetaCyc:DUTP-PYROP-RXN
xref: Reactome:REACT_103311 "dUTP + H2O => dUMP + pyrophosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_106534 "dUTP + H2O => dUMP + pyrophosphate, Drosophila melanogaster"
xref: Reactome:REACT_108277 "dUTP + H2O => dUMP + pyrophosphate, Canis familiaris"
xref: Reactome:REACT_108948 "dUTP + H2O => dUMP + pyrophosphate, Rattus norvegicus"
xref: Reactome:REACT_109343 "dUTP + H2O => dUMP + pyrophosphate, Gallus gallus"
xref: Reactome:REACT_150 "dUTP + H2O => dUMP + pyrophosphate, Homo sapiens"
xref: Reactome:REACT_30531 "dUTP + H2O => dUMP + pyrophosphate, Mycobacterium tuberculosis"
xref: Reactome:REACT_54215 "dUTP + H2O => dUMP + pyrophosphate, Bos taurus"
xref: Reactome:REACT_76954 "dUTP + H2O => dUMP + pyrophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_77124 "dUTP + H2O => dUMP + pyrophosphate, Danio rerio"
xref: Reactome:REACT_81301 "dUTP + H2O => dUMP + pyrophosphate, Arabidopsis thaliana"
xref: Reactome:REACT_82609 "dUTP + H2O => dUMP + pyrophosphate, Mus musculus"
xref: Reactome:REACT_87407 "dUTP + H2O => dUMP + pyrophosphate, Escherichia coli"
xref: Reactome:REACT_92173 "dUTP + H2O => dUMP + pyrophosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_92619 "dUTP + H2O => dUMP + pyrophosphate, Caenorhabditis elegans"
xref: Reactome:REACT_96660 "dUTP + H2O => dUMP + pyrophosphate, Oryza sativa"
xref: Reactome:REACT_96711 "dUTP + H2O => dUMP + pyrophosphate, Plasmodium falciparum"
xref: Reactome:REACT_97265 "dUTP + H2O => dUMP + pyrophosphate, Taeniopygia guttata"
xref: RHEA:10251
is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity

[Term]
id: GO:0004171
name: obsolete deoxyhypusine synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine." [EC:2.5.1.46]
comment: This term was made obsolete because it represents a multistep reaction.
synonym: "[eIF-5A]-deoxyhypusine synthase" RELATED []
synonym: "deoxyhypusine synthase activity" EXACT []
is_obsolete: true
consider: GO:0008612
consider: GO:0034038
consider: GO:0050983

[Term]
id: GO:0004172
name: obsolete ecdysteroid UDP-glucosyl/UDP-glucuronosyl transferase activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents two molecular functions.
synonym: "ecdysteroid UDP-glucosyl/UDP-glucuronosyl transferase activity" EXACT []
is_obsolete: true
consider: GO:0050488

[Term]
id: GO:0004173
name: ecdysone O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: Ecdysone + palmitoyl-CoA = CoA + ecdysone palmitate." [EC:2.3.1.139, RHEA:15220]
synonym: "acyl-CoA:ecdysone acyltransferase activity" EXACT [EC:2.3.1.139]
synonym: "fatty acyl-CoA:ecdysone acyltransferase activity" EXACT [EC:2.3.1.139]
synonym: "palmitoyl-CoA:ecdysone palmitoyltransferase activity" EXACT [EC:2.3.1.139]
xref: EC:2.3.1.139
xref: KEGG:R02375
xref: MetaCyc:ECDYSONE-O-ACYLTRANSFERASE-RXN
xref: RHEA:15220
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0004174
name: electron-transferring-flavoprotein dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: reduced ETF + ubiquinone = ETF + ubiquinol." [EC:1.5.5.1]
subset: gosubset_prok
synonym: "electron transfer flavoprotein dehydrogenase activity" EXACT [EC:1.5.5.1]
synonym: "electron transfer flavoprotein Q oxidoreductase activity" EXACT [EC:1.5.5.1]
synonym: "electron transfer flavoprotein reductase activity" EXACT [EC:1.5.5.1]
synonym: "electron transfer flavoprotein-ubiquinone oxidoreductase activity" EXACT [EC:1.5.5.1]
synonym: "electron-transferring-flavoprotein:ubiquinone oxidoreductase activity" EXACT [EC:1.5.5.1]
synonym: "ETF dehydrogenase activity" EXACT [EC:1.5.5.1]
synonym: "ETF-QO activity" EXACT [EC:1.5.5.1]
synonym: "ETF-ubiquinone oxidoreductase activity" EXACT [EC:1.5.5.1]
synonym: "ETF:ubiquinone oxidoreductase activity" EXACT [EC:1.5.5.1]
xref: EC:1.5.5.1
xref: MetaCyc:1.5.5.1-RXN
xref: Reactome:REACT_101766 "Transfer of electrons from ETF to ubiquinone by ETF-QO, Oryza sativa"
xref: Reactome:REACT_108322 "Transfer of electrons from ETF to ubiquinone by ETF-QO, Danio rerio"
xref: Reactome:REACT_108711 "Transfer of electrons from ETF to ubiquinone by ETF-QO, Rattus norvegicus"
xref: Reactome:REACT_32375 "Transfer of electrons from ETF to ubiquinone by ETF-QO, Taeniopygia guttata"
xref: Reactome:REACT_32665 "Transfer of electrons from ETF to ubiquinone by ETF-QO, Saccharomyces cerevisiae"
xref: Reactome:REACT_32923 "Transfer of electrons from ETF to ubiquinone by ETF-QO, Arabidopsis thaliana"
xref: Reactome:REACT_34198 "Transfer of electrons from ETF to ubiquinone by ETF-QO, Sus scrofa"
xref: Reactome:REACT_6169 "Transfer of electrons from ETF to ubiquinone by ETF-QO, Homo sapiens"
xref: Reactome:REACT_82024 "Transfer of electrons from ETF to ubiquinone by ETF-QO, Escherichia coli"
xref: Reactome:REACT_82357 "Transfer of electrons from ETF to ubiquinone by ETF-QO, Canis familiaris"
xref: Reactome:REACT_84406 "Transfer of electrons from ETF to ubiquinone by ETF-QO, Schizosaccharomyces pombe"
xref: Reactome:REACT_84920 "Transfer of electrons from ETF to ubiquinone by ETF-QO, Bos taurus"
xref: Reactome:REACT_85394 "Transfer of electrons from ETF to ubiquinone by ETF-QO, Caenorhabditis elegans"
xref: Reactome:REACT_88723 "Transfer of electrons from ETF to ubiquinone by ETF-QO, Dictyostelium discoideum"
xref: Reactome:REACT_88890 "Transfer of electrons from ETF to ubiquinone by ETF-QO, Drosophila melanogaster"
xref: Reactome:REACT_95350 "Transfer of electrons from ETF to ubiquinone by ETF-QO, Mus musculus"
xref: Reactome:REACT_98526 "Transfer of electrons from ETF to ubiquinone by ETF-QO, Xenopus tropicalis"
is_a: GO:0016649 ! oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor

[Term]
id: GO:0004175
name: endopeptidase activity
namespace: molecular_function
alt_id: GO:0016809
def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain." [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
subset: gosubset_prok
synonym: "elastase activity" RELATED [GOC:krc]
synonym: "endoprotease activity" NARROW []
synonym: "proteasome endopeptidase activity" NARROW []
synonym: "proteinase" NARROW []
xref: Reactome:REACT_10017 "Degradation of ubiquitinated -beta catenin by the proteasome, Homo sapiens"
xref: Reactome:REACT_101348 "Degradation of multiubiquitinated Cdh1, Rattus norvegicus"
xref: Reactome:REACT_101866 "Ubiquitinated Cdc6 is degraded by the proteasome, Canis familiaris"
xref: Reactome:REACT_101873 "Degradation of multiubiquitinated cell cycle proteins, Mus musculus"
xref: Reactome:REACT_102952 "Degradation of multiubiquitinated Cdh1, Bos taurus"
xref: Reactome:REACT_103814 "Degradation multiubiquitinated Cyclin A, Xenopus tropicalis"
xref: Reactome:REACT_104331 "Ubiquitinated geminin is degraded by the proteasome, Mus musculus"
xref: Reactome:REACT_104435 "Proteasome mediated degradation of Cyclin D1, Rattus norvegicus"
xref: Reactome:REACT_104684 "Degradation of multiubiquitinated Cdh1, Danio rerio"
xref: Reactome:REACT_104793 "Ubiquitinated Cdc6 is degraded by the proteasome, Mus musculus"
xref: Reactome:REACT_105135 "Degradation of ubiquitinated -beta catenin by the proteasome, Canis familiaris"
xref: Reactome:REACT_105245 "Ubiquitinated Orc1 is degraded by the proteasome, Danio rerio"
xref: Reactome:REACT_105748 "APC/C:Cdh1-mediated degradation of Skp2, Canis familiaris"
xref: Reactome:REACT_106234 "Ubiquitinated Orc1 is degraded by the proteasome, Mus musculus"
xref: Reactome:REACT_106385 "Proteasome mediated degradation of COP1, Xenopus tropicalis"
xref: Reactome:REACT_106617 "gamma-secretase cleaves the p75NTR transmembrane domain, Bos taurus"
xref: Reactome:REACT_106687 "SCF-mediated degradation of Emi1, Bos taurus"
xref: Reactome:REACT_107139 "Ubiquitinated geminin is degraded by the proteasome, Canis familiaris"
xref: Reactome:REACT_107146 "Ubiquitinated Orc1 is degraded by the proteasome, Bos taurus"
xref: Reactome:REACT_108185 "Ubiquitinated Orc1 is degraded by the proteasome, Oryza sativa"
xref: Reactome:REACT_108448 "Proteasome mediated degradation of PAK-2p34, Mus musculus"
xref: Reactome:REACT_108642 "Ubiquitinated geminin is degraded by the proteasome, Xenopus tropicalis"
xref: Reactome:REACT_109047 "Degradation of multiubiquitinated Cdh1, Oryza sativa"
xref: Reactome:REACT_109186 "Ubiquitinated Cdc6 is degraded by the proteasome, Danio rerio"
xref: Reactome:REACT_109261 "Degradation of multiubiquitinated cell cycle proteins, Oryza sativa"
xref: Reactome:REACT_110165 "Degradation of ubiquitinated p27/p21 by the 26S proteasome, Danio rerio"
xref: Reactome:REACT_110191 "26S proteosome degrades ODC holoenzyme complex, Canis familiaris"
xref: Reactome:REACT_110448 "Proteolytic degradation of ubiquitinated-Cdc25A, Xenopus tropicalis"
xref: Reactome:REACT_110469 "gamma-secretase cleaves the p75NTR transmembrane domain, Rattus norvegicus"
xref: Reactome:REACT_110487 "Proteolytic degradation of ubiquitinated-Cdc25A, Danio rerio"
xref: Reactome:REACT_110752 "gamma-secretase cleaves the p75NTR transmembrane domain, Canis familiaris"
xref: Reactome:REACT_111098 "Processing of SCF isoform 1, Homo sapiens"
xref: Reactome:REACT_111104 "Proteasomal cleavage of substrate, Homo sapiens"
xref: Reactome:REACT_111172 "Proteasomal clevage of exogenous antigen, Homo sapiens"
xref: Reactome:REACT_112076 "Ubiquitinated Cdc6 is degraded by the proteasome, Sus scrofa"
xref: Reactome:REACT_113623 "Ubiquitinated geminin is degraded by the proteasome, Sus scrofa"
xref: Reactome:REACT_113749 "Ubiquitinated Orc1 is degraded by the proteasome, Sus scrofa"
xref: Reactome:REACT_114002 "Proteasome mediated degradation of PAK-2p34, Sus scrofa"
xref: Reactome:REACT_114449 "Proteasome mediated degradation of Cyclin D1, Sus scrofa"
xref: Reactome:REACT_114993 "Proteasome mediated degradation of COP1, Sus scrofa"
xref: Reactome:REACT_115363 "Proteasome mediated degradation of Cyclin D1, Oryza sativa"
xref: Reactome:REACT_115913 "Cleavage of ERBB4m80 by gamma-scretase complex, Homo sapiens"
xref: Reactome:REACT_1210 "Ubiquitinated Cdc6 is degraded by the proteasome, Homo sapiens"
xref: Reactome:REACT_13413 "Proteasome mediated degradation of PAK-2p34, Homo sapiens"
xref: Reactome:REACT_13491 "26S proteosome degrades ODC holoenzyme complex, Homo sapiens"
xref: Reactome:REACT_13505 "Proteasome mediated degradation of PAK-2p34, Homo sapiens"
xref: Reactome:REACT_1355 "Insulin degradation, Homo sapiens"
xref: Reactome:REACT_13609 "gamma-secretase cleaves the p75NTR transmembrane domain, Homo sapiens"
xref: Reactome:REACT_1471 "Ubiquitinated geminin is degraded by the proteasome, Homo sapiens"
xref: Reactome:REACT_15476 "Corticotropin cleavage from POMC, Homo sapiens"
xref: Reactome:REACT_1673 "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex, Homo sapiens"
xref: Reactome:REACT_20637 "Proteasome mediated degradation of COP1, Homo sapiens"
xref: Reactome:REACT_2142 "Proteasome mediated degradation of Cyclin D1, Homo sapiens"
xref: Reactome:REACT_25343 "Destruction of AUF1 and mRNA, Homo sapiens"
xref: Reactome:REACT_28448 "Ubiquitinated Orc1 is degraded by the proteasome, Dictyostelium discoideum"
xref: Reactome:REACT_28452 "Proteasome mediated degradation of COP1, Bos taurus"
xref: Reactome:REACT_28694 "Proteasome mediated degradation of Cyclin D1, Bos taurus"
xref: Reactome:REACT_29497 "Corticotropin cleavage from POMC, Rattus norvegicus"
xref: Reactome:REACT_29888 "Proteasome mediated degradation of COP1, Dictyostelium discoideum"
xref: Reactome:REACT_30554 "APC/C:Cdh1-mediated degradation of Skp2, Mus musculus"
xref: Reactome:REACT_31644 "Degradation of ubiquitinated -beta catenin by the proteasome, Mus musculus"
xref: Reactome:REACT_32286 "Corticotropin cleavage from POMC, Gallus gallus"
xref: Reactome:REACT_32345 "Proteasome mediated degradation of COP1, Rattus norvegicus"
xref: Reactome:REACT_32454 "Corticotropin cleavage from POMC, Mus musculus"
xref: Reactome:REACT_33103 "26S proteosome degrades ODC holoenzyme complex, Xenopus tropicalis"
xref: Reactome:REACT_33361 "Degradation of multiubiquitinated Securin, Xenopus tropicalis"
xref: Reactome:REACT_33702 "Proteasome mediated degradation of PAK-2p34, Drosophila melanogaster"
xref: Reactome:REACT_34207 "Proteasome mediated degradation of PAK-2p34, Canis familiaris"
xref: Reactome:REACT_34441 "Proteolytic degradation of ubiquitinated-Cdc25A, Rattus norvegicus"
xref: Reactome:REACT_38775 "Ubiquitinated geminin is degraded by the proteasome, Bos taurus"
xref: Reactome:REACT_480 "Ubiquitinated Orc1 is degraded by the proteasome, Homo sapiens"
xref: Reactome:REACT_6715 "Degradation of multiubiquitinated Cdh1, Homo sapiens"
xref: Reactome:REACT_6777 "Degradation of multiubiquitinated Securin, Homo sapiens"
xref: Reactome:REACT_6826 "Degradation of multiubiquitinated cell cycle proteins, Homo sapiens"
xref: Reactome:REACT_6878 "SCF-mediated degradation of Emi1, Homo sapiens"
xref: Reactome:REACT_6937 "Degradation multiubiquitinated Cyclin A, Homo sapiens"
xref: Reactome:REACT_75798 "Trimming of peptides in ER, Homo sapiens"
xref: Reactome:REACT_75871 "Proteasomal cleavage of substrate, Homo sapiens"
xref: Reactome:REACT_78097 "Proteasome mediated degradation of COP1, Canis familiaris"
xref: Reactome:REACT_78726 "gamma-secretase cleaves the p75NTR transmembrane domain, Xenopus tropicalis"
xref: Reactome:REACT_78745 "Proteasome mediated degradation of Cyclin D1, Drosophila melanogaster"
xref: Reactome:REACT_78867 "Degradation multiubiquitinated Cyclin A, Rattus norvegicus"
xref: Reactome:REACT_79225 "Degradation of multiubiquitinated Cdh1, Canis familiaris"
xref: Reactome:REACT_79268 "Degradation of ubiquitinated -beta catenin by the proteasome, Drosophila melanogaster"
xref: Reactome:REACT_79271 "Proteasome mediated degradation of Cyclin D1, Canis familiaris"
xref: Reactome:REACT_79593 "Corticotropin cleavage from POMC, Xenopus tropicalis"
xref: Reactome:REACT_79599 "26S proteosome degrades ODC holoenzyme complex, Danio rerio"
xref: Reactome:REACT_79815 "gamma-secretase cleaves the p75NTR transmembrane domain, Gallus gallus"
xref: Reactome:REACT_79882 "APC/C:Cdh1-mediated degradation of Skp2, Rattus norvegicus"
xref: Reactome:REACT_80109 "gamma-secretase cleaves the p75NTR transmembrane domain, Danio rerio"
xref: Reactome:REACT_80331 "APC/C:Cdh1-mediated degradation of Skp2, Xenopus tropicalis"
xref: Reactome:REACT_80442 "Ubiquitinated Cdc6 is degraded by the proteasome, Drosophila melanogaster"
xref: Reactome:REACT_80463 "Degradation of multiubiquitinated Securin, Danio rerio"
xref: Reactome:REACT_80748 "Degradation multiubiquitinated Cyclin A, Bos taurus"
xref: Reactome:REACT_80774 "Degradation of multiubiquitinated cell cycle proteins, Rattus norvegicus"
xref: Reactome:REACT_80978 "Proteasome mediated degradation of PAK-2p34, Xenopus tropicalis"
xref: Reactome:REACT_81238 "Corticotropin cleavage from POMC, Bos taurus"
xref: Reactome:REACT_81327 "SCF-mediated degradation of Emi1, Mus musculus"
xref: Reactome:REACT_81867 "Ubiquitinated Cdc6 is degraded by the proteasome, Bos taurus"
xref: Reactome:REACT_81958 "Degradation of ubiquitinated p27/p21 by the 26S proteasome, Canis familiaris"
xref: Reactome:REACT_82043 "Ubiquitinated Orc1 is degraded by the proteasome, Canis familiaris"
xref: Reactome:REACT_82474 "Ubiquitinated Cdc6 is degraded by the proteasome, Dictyostelium discoideum"
xref: Reactome:REACT_82600 "Degradation of multiubiquitinated cell cycle proteins, Xenopus tropicalis"
xref: Reactome:REACT_82845 "26S proteosome degrades ODC holoenzyme complex, Rattus norvegicus"
xref: Reactome:REACT_82963 "Degradation of multiubiquitinated cell cycle proteins, Drosophila melanogaster"
xref: Reactome:REACT_83099 "Degradation of ubiquitinated p27/p21 by the 26S proteasome, Bos taurus"
xref: Reactome:REACT_83216 "gamma-secretase cleaves the p75NTR transmembrane domain, Sus scrofa"
xref: Reactome:REACT_83748 "Degradation of multiubiquitinated Cdh1, Drosophila melanogaster"
xref: Reactome:REACT_84139 "Proteasome mediated degradation of COP1, Danio rerio"
xref: Reactome:REACT_85078 "APC/C:Cdh1-mediated degradation of Skp2, Drosophila melanogaster"
xref: Reactome:REACT_86353 "Corticotropin cleavage from POMC, Danio rerio"
xref: Reactome:REACT_86565 "SCF-mediated degradation of Emi1, Rattus norvegicus"
xref: Reactome:REACT_873 "Proteolytic degradation of ubiquitinated-Cdc25A, Homo sapiens"
xref: Reactome:REACT_88382 "Proteasome mediated degradation of COP1, Mus musculus"
xref: Reactome:REACT_88509 "Proteasome mediated degradation of Cyclin D1, Mus musculus"
xref: Reactome:REACT_88535 "Ubiquitinated Orc1 is degraded by the proteasome, Plasmodium falciparum"
xref: Reactome:REACT_88610 "Degradation multiubiquitinated Cyclin A, Canis familiaris"
xref: Reactome:REACT_88818 "Degradation multiubiquitinated Cyclin A, Drosophila melanogaster"
xref: Reactome:REACT_88854 "Corticotropin cleavage from POMC, Taeniopygia guttata"
xref: Reactome:REACT_89011 "Ubiquitinated Orc1 is degraded by the proteasome, Rattus norvegicus"
xref: Reactome:REACT_89036 "Ubiquitinated geminin is degraded by the proteasome, Danio rerio"
xref: Reactome:REACT_89437 "26S proteosome degrades ODC holoenzyme complex, Bos taurus"
xref: Reactome:REACT_89505 "Corticotropin cleavage from POMC, Sus scrofa"
xref: Reactome:REACT_89706 "Degradation of multiubiquitinated Cdh1, Xenopus tropicalis"
xref: Reactome:REACT_90062 "SCF-mediated degradation of Emi1, Canis familiaris"
xref: Reactome:REACT_9018 "Degradation of ubiquitinated CD4, Homo sapiens"
xref: Reactome:REACT_9034 "Degradation of ubiquitinated p27/p21 by the 26S proteasome, Homo sapiens"
xref: Reactome:REACT_9035 "APC/C:Cdh1-mediated degradation of Skp2, Homo sapiens"
xref: Reactome:REACT_90527 "SCF-mediated degradation of Emi1, Drosophila melanogaster"
xref: Reactome:REACT_90608 "Proteasome mediated degradation of Cyclin D1, Danio rerio"
xref: Reactome:REACT_91284 "Degradation of ubiquitinated -beta catenin by the proteasome, Bos taurus"
xref: Reactome:REACT_91685 "Degradation of ubiquitinated -beta catenin by the proteasome, Rattus norvegicus"
xref: Reactome:REACT_91903 "Ubiquitinated Cdc6 is degraded by the proteasome, Rattus norvegicus"
xref: Reactome:REACT_92046 "Corticotropin cleavage from POMC, Canis familiaris"
xref: Reactome:REACT_92221 "Ubiquitinated Cdc6 is degraded by the proteasome, Xenopus tropicalis"
xref: Reactome:REACT_92347 "Proteasome mediated degradation of COP1, Oryza sativa"
xref: Reactome:REACT_92586 "Degradation of ubiquitinated p27/p21 by the 26S proteasome, Xenopus tropicalis"
xref: Reactome:REACT_92969 "Proteolytic degradation of ubiquitinated-Cdc25A, Bos taurus"
xref: Reactome:REACT_93063 "Proteasome mediated degradation of PAK-2p34, Danio rerio"
xref: Reactome:REACT_93174 "SCF-mediated degradation of Emi1, Xenopus tropicalis"
xref: Reactome:REACT_93453 "Degradation of multiubiquitinated Cdh1, Mus musculus"
xref: Reactome:REACT_93935 "gamma-secretase cleaves the p75NTR transmembrane domain, Mus musculus"
xref: Reactome:REACT_94290 "Degradation of ubiquitinated p27/p21 by the 26S proteasome, Rattus norvegicus"
xref: Reactome:REACT_9466 "Proteosome-mediated degradation of APOBEC3G, Homo sapiens"
xref: Reactome:REACT_94694 "Degradation of multiubiquitinated Securin, Canis familiaris"
xref: Reactome:REACT_95326 "Degradation of multiubiquitinated cell cycle proteins, Canis familiaris"
xref: Reactome:REACT_95413 "Degradation of multiubiquitinated cell cycle proteins, Danio rerio"
xref: Reactome:REACT_95513 "Proteolytic degradation of ubiquitinated-Cdc25A, Canis familiaris"
xref: Reactome:REACT_95865 "Proteolytic degradation of ubiquitinated-Cdc25A, Mus musculus"
xref: Reactome:REACT_96387 "Degradation multiubiquitinated Cyclin A, Mus musculus"
xref: Reactome:REACT_96712 "Degradation of multiubiquitinated Securin, Drosophila melanogaster"
xref: Reactome:REACT_96853 "Ubiquitinated Orc1 is degraded by the proteasome, Xenopus tropicalis"
xref: Reactome:REACT_96908 "Ubiquitinated Orc1 is degraded by the proteasome, Drosophila melanogaster"
xref: Reactome:REACT_97049 "Ubiquitinated Cdc6 is degraded by the proteasome, Oryza sativa"
xref: Reactome:REACT_97235 "APC/C:Cdh1-mediated degradation of Skp2, Danio rerio"
xref: Reactome:REACT_97302 "Proteasome mediated degradation of Cyclin D1, Xenopus tropicalis"
xref: Reactome:REACT_97473 "Degradation of ubiquitinated p27/p21 by the 26S proteasome, Mus musculus"
xref: Reactome:REACT_97709 "Degradation multiubiquitinated Cyclin A, Danio rerio"
xref: Reactome:REACT_97826 "Degradation of multiubiquitinated cell cycle proteins, Bos taurus"
xref: Reactome:REACT_97966 "APC/C:Cdh1-mediated degradation of Skp2, Oryza sativa"
xref: Reactome:REACT_98412 "APC/C:Cdh1-mediated degradation of Skp2, Bos taurus"
xref: Reactome:REACT_98429 "Degradation of ubiquitinated -beta catenin by the proteasome, Xenopus tropicalis"
xref: Reactome:REACT_98617 "Degradation of multiubiquitinated Securin, Mus musculus"
xref: Reactome:REACT_98707 "Proteasome mediated degradation of PAK-2p34, Rattus norvegicus"
xref: Reactome:REACT_98822 "Degradation of multiubiquitinated Securin, Rattus norvegicus"
xref: Reactome:REACT_98901 "Degradation of multiubiquitinated Securin, Bos taurus"
xref: Reactome:REACT_98932 "Ubiquitinated geminin is degraded by the proteasome, Rattus norvegicus"
xref: Reactome:REACT_99506 "26S proteosome degrades ODC holoenzyme complex, Mus musculus"
xref: Reactome:REACT_99644 "Proteolytic degradation of ubiquitinated-Cdc25A, Drosophila melanogaster"
is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides

[Term]
id: GO:0004176
name: ATP-dependent peptidase activity
namespace: molecular_function
alt_id: GO:0004280
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the hydrolysis of peptide bonds." [GOC:mah]
subset: gosubset_prok
synonym: "ATP-dependent proteolysis" RELATED [GOC:mah]
is_a: GO:0042623 ! ATPase activity, coupled
is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides

[Term]
id: GO:0004177
name: aminopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
xref: EC:3.4.11
xref: Reactome:REACT_111222 "Trimming of peptides by IRAP in endocytic vesicles, Homo sapiens"
xref: Reactome:REACT_75931 "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases, Homo sapiens"
is_a: GO:0008238 ! exopeptidase activity

[Term]
id: GO:0004178
name: obsolete leucyl aminopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of an N-terminal amino acid, Xaa-Xbb-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Xbb may be Pro." [EC:3.4.11.1]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "aminopeptidase II" RELATED [EC:3.4.11.1]
synonym: "cathepsin III" RELATED [EC:3.4.11.1]
synonym: "cytosol aminopeptidase activity" NARROW [EC:3.4.11.1]
synonym: "FTBL proteins" RELATED [EC:3.4.11.1]
synonym: "L-leucine aminopeptidase activity" EXACT [EC:3.4.11.1]
synonym: "leucinamide aminopeptidase activity" EXACT [EC:3.4.11.1]
synonym: "leucinaminopeptidase activity" EXACT [EC:3.4.11.1]
synonym: "leucine aminopeptidase activity" EXACT [EC:3.4.11.1]
synonym: "leucyl aminopeptidase activity" EXACT []
synonym: "leucyl peptidase activity" EXACT [EC:3.4.11.1]
synonym: "peptidase S activity" NARROW [EC:3.4.11.1]
synonym: "proteinates FTBL" RELATED [EC:3.4.11.1]
xref: EC:3.4.11.1
xref: MetaCyc:3.4.11.1-RXN
is_obsolete: true
consider: GO:0004177
consider: GO:0008235

[Term]
id: GO:0004179
name: obsolete membrane alanyl aminopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of an N-terminal amino acid, Xaa-Xbb- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide." [EC:3.4.11.2]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "alanine-specific aminopeptidase activity" EXACT [EC:3.4.11.2]
synonym: "alanyl aminopeptidase activity" EXACT [EC:3.4.11.2]
synonym: "amino-oligopeptidase activity" EXACT [EC:3.4.11.2]
synonym: "aminopeptidase M activity" NARROW [EC:3.4.11.2]
synonym: "aminopeptidase N activity" NARROW [EC:3.4.11.2]
synonym: "CD13" RELATED [EC:3.4.11.2]
synonym: "cysteinylglycinase activity" EXACT [EC:3.4.11.2]
synonym: "cysteinylglycine dipeptidase activity" EXACT [EC:3.4.11.2]
synonym: "L-alanine aminopeptidase activity" EXACT [EC:3.4.11.2]
synonym: "membrane alanine aminopeptidase activity" NARROW [EC:3.4.11.2]
synonym: "membrane alanyl aminopeptidase activity" EXACT []
synonym: "membrane aminopeptidase I activity" NARROW [EC:3.4.11.2]
synonym: "microsomal aminopeptidase activity" NARROW [EC:3.4.11.2]
synonym: "particle-bound aminopeptidase activity" NARROW [EC:3.4.11.2]
synonym: "peptidase E activity" BROAD [EC:3.4.11.2]
synonym: "pseudo leucine aminopeptidase activity" EXACT [EC:3.4.11.2]
xref: EC:3.4.11.2
xref: MetaCyc:3.4.11.2-RXN
is_obsolete: true
consider: GO:0004177
consider: GO:0008235

[Term]
id: GO:0004180
name: carboxypeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732]
subset: gosubset_prok
xref: Reactome:REACT_75845 "A dipeptidase cleaves cysteinylglycine, Homo sapiens"
is_a: GO:0008238 ! exopeptidase activity

[Term]
id: GO:0004181
name: metallocarboxypeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732]
subset: gosubset_prok
xref: EC:3.4.17
xref: Reactome:REACT_103434 "Processing of Proinsulin to Insulin, Rattus norvegicus"
xref: Reactome:REACT_104808 "Processing of Proinsulin to Insulin, Taeniopygia guttata"
xref: Reactome:REACT_15374 "Processing of Proinsulin to Insulin, Homo sapiens"
xref: Reactome:REACT_30489 "Processing of Proinsulin to Insulin, Danio rerio"
xref: Reactome:REACT_31280 "Processing of Proinsulin to Insulin, Xenopus tropicalis"
xref: Reactome:REACT_34275 "Processing of Proinsulin to Insulin, Bos taurus"
xref: Reactome:REACT_76942 "Processing of Proinsulin to Insulin, Canis familiaris"
xref: Reactome:REACT_85582 "Processing of Proinsulin to Insulin, Mus musculus"
xref: Reactome:REACT_93274 "Processing of Proinsulin to Insulin, Gallus gallus"
is_a: GO:0004180 ! carboxypeptidase activity
is_a: GO:0008235 ! metalloexopeptidase activity

[Term]
id: GO:0004182
name: obsolete carboxypeptidase A activity
namespace: molecular_function
alt_id: GO:0008731
def: "OBSOLETE. Catalysis of the reaction: peptidyl-L-amino acid + H2O = peptide + L-amino acid. Little or no action with -Asp, -Glu, -Arg, -Lys or -Pro." [EC:3.4.17.1]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "carboxypeptidase A activity" EXACT []
synonym: "carboxypolypeptidase activity" EXACT [EC:3.4.17.1]
synonym: "pancreatic carboxypeptidase A" RELATED [EC:3.4.17.1]
synonym: "tissue carboxypeptidase A" RELATED [EC:3.4.17.1]
xref: EC:3.4.17.1
xref: MetaCyc:CARBOXYPEPTIDASE-A-RXN
is_obsolete: true
replaced_by: GO:0004181

[Term]
id: GO:0004183
name: obsolete carboxypeptidase E activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Function is activated by Co2+ and inhibited by 1,10-phenanthroline and other chelating agents." [EC:3.4.17.10]
comment: This term was made obsolete because it represents a gene product.
synonym: "carboxypeptidase E activity" EXACT []
synonym: "carboxypeptidase H activity" EXACT []
synonym: "cobalt-stimulated chromaffin granule carboxypeptidase activity" EXACT [EC:3.4.17.10]
synonym: "enkephalin convertase activity" NARROW [EC:3.4.17.10]
synonym: "enkephalin precursor carboxypeptidase activity" EXACT [EC:3.4.17.10]
synonym: "enkephalin-precursor endopeptidase activity" EXACT [EC:3.4.17.10]
synonym: "insulin granule-associated carboxypeptidase activity" EXACT [EC:3.4.17.10]
synonym: "membrane-bound carboxypeptidase activity" EXACT [EC:3.4.17.10]
synonym: "peptidyl-L-lysine(-L-arginine) hydrolase" BROAD [EC:3.4.17.10]
xref: EC:3.4.17.10
xref: MetaCyc:CARBOXYPEPTIDASE-H-RXN
is_obsolete: true
replaced_by: GO:0004181

[Term]
id: GO:0004184
name: obsolete lysine carboxypeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Release of a C-terminal basic amino acid, preferentially lysine; inactivates bradykinin and anaphylatoxins in blood plasma." [EC:3.4.17.3]
comment: This term was made obsolete because it represents a gene product.
synonym: "anaphylatoxin inactivator activity" NARROW [EC:3.4.17.3]
synonym: "arginine carboxypeptidase activity" EXACT [EC:3.4.17.3]
synonym: "bradykinase activity" EXACT [EC:3.4.17.3]
synonym: "bradykinin-decomposing enzyme" RELATED [EC:3.4.17.3]
synonym: "carboxypeptidase N activity" EXACT []
synonym: "CPase N" RELATED [EC:3.4.17.3]
synonym: "creatine kinase conversion factor" RELATED [EC:3.4.17.3]
synonym: "creatinine kinase convertase activity" EXACT [EC:3.4.17.3]
synonym: "hippuryllysine hydrolase activity" EXACT [EC:3.4.17.3]
synonym: "kininase I activity" EXACT [EC:3.4.17.3]
synonym: "kininase Ia" RELATED [EC:3.4.17.3]
synonym: "lysine (arginine) carboxypeptidase activity" EXACT []
synonym: "lysine carboxypeptidase activity" EXACT []
synonym: "lysine(arginine) carboxypeptidase activity" EXACT [EC:3.4.17.3]
synonym: "peptidyl-L-lysine(-L-arginine) hydrolase" BROAD [EC:3.4.17.3]
synonym: "plasma carboxypeptidase B" RELATED [EC:3.4.17.3]
xref: EC:3.4.17.3
xref: MetaCyc:LYSINEARGININE-CARBOXYPEPTIDASE-RXN
is_obsolete: true
replaced_by: GO:0004181

[Term]
id: GO:0004185
name: serine-type carboxypeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
subset: gosubset_prok
synonym: "serine carboxypeptidase activity" EXACT []
xref: EC:3.4.16
xref: Reactome:REACT_109426 "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer, Bos taurus"
xref: Reactome:REACT_6 "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer, Homo sapiens"
xref: Reactome:REACT_79406 "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer, Mus musculus"
xref: Reactome:REACT_83670 "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer, Rattus norvegicus"
xref: Reactome:REACT_92499 "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer, Gallus gallus"
xref: Reactome:REACT_95826 "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer, Canis familiaris"
xref: Reactome:REACT_98506 "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer, Taeniopygia guttata"
is_a: GO:0004180 ! carboxypeptidase activity
is_a: GO:0070008 ! serine-type exopeptidase activity

[Term]
id: GO:0004186
name: obsolete carboxypeptidase C activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of a C-terminal amino acid with a broad specificity." [EC:3.4.16.5]
comment: This term was made obsolete because it represents a gene product.
synonym: "carboxypeptidase C activity" EXACT []
synonym: "carboxypeptidase Y activity" EXACT [EC:3.4.16.5]
synonym: "cathepsin A activity" NARROW [EC:3.4.16.5]
synonym: "deamidase" RELATED [EC:3.4.16.5]
synonym: "lysosomal carboxypeptidase A" NARROW [EC:3.4.16.5]
synonym: "lysosomal protective protein activity" NARROW [EC:3.4.16.5]
synonym: "serine carboxypeptidase I activity" EXACT [EC:3.4.16.5]
synonym: "serine-type carboxypeptidase I activity" EXACT [EC:3.4.16.5]
synonym: "vacuolar carboxypeptidase Y" NARROW []
xref: EC:3.4.16.5
xref: MetaCyc:3.4.16.5-RXN
is_obsolete: true
replaced_by: GO:0004185

[Term]
id: GO:0004187
name: obsolete carboxypeptidase D activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the preferential release of a C-terminal arginine or lysine residue. Function is inhibited by diisopropyl fluorophosphate and sensitive to thiol-blocking reagents." [EC:3.4.16.6]
comment: This term was made obsolete because it represents a gene product.
synonym: "carboxypeptidase D activity" EXACT []
synonym: "carboxypeptidase Kex1" RELATED [EC:3.4.16.6]
synonym: "carboxypeptidase KEX1 activity" NARROW [EC:3.4.16.6]
synonym: "carboxypeptidase S1 activity" EXACT [EC:3.4.16.6]
synonym: "cereal serine carboxypeptidase II" RELATED [EC:3.4.16.6]
synonym: "CPDW-II" RELATED [EC:3.4.16.6]
synonym: "gene KEX1 serine carboxypeptidase" NARROW [EC:3.4.16.6]
synonym: "KEX1 carboxypeptidase activity" EXACT [EC:3.4.16.6]
synonym: "KEX1 proteinase activity" EXACT [EC:3.4.16.6]
synonym: "KEX1DELTAp" RELATED [EC:3.4.16.6]
synonym: "saccharomyces cerevisiae KEX1 gene product" RELATED [EC:3.4.16.6]
xref: EC:3.4.16.6
xref: MetaCyc:3.4.16.6-RXN
is_obsolete: true
replaced_by: GO:0004185

[Term]
id: GO:0004188
name: obsolete serine-type Pro-X carboxypeptidase activity
namespace: molecular_function
alt_id: GO:0008323
def: "OBSOLETE. Catalysis of the cleavage of a Pro-Xaa bond by a serine-type peptidase mechanism to release a C-terminal amino acid." [EC:3.4.16.2]
comment: This term was made obsolete because it represents a gene product.
synonym: "aminoacylproline carboxypeptidase activity" EXACT [EC:3.4.16.2]
synonym: "angiotensinase C activity" NARROW [EC:3.4.16.2]
synonym: "lysosomal carboxypeptidase C activity" NARROW [EC:3.4.16.2]
synonym: "lysosomal Pro-X carboxypeptidase activity" NARROW []
synonym: "lysosomal Pro-Xaa carboxypeptidase activity" EXACT [EC:3.4.16.2]
synonym: "PCP" RELATED [EC:3.4.16.2]
synonym: "peptidylprolylamino acid carboxypeptidase activity" EXACT [EC:3.4.16.2]
synonym: "proline carboxypeptidase activity" EXACT [EC:3.4.16.2]
synonym: "proline-specific carboxypeptidase P" RELATED [EC:3.4.16.2]
synonym: "prolyl carboxypeptidase activity" EXACT [EC:3.4.16.2]
synonym: "serine-type Pro-X carboxypeptidase activity" EXACT []
xref: EC:3.4.16.2
xref: MetaCyc:3.4.16.2-RXN
is_obsolete: true
replaced_by: GO:0004185

[Term]
id: GO:0004189
name: obsolete tubulinyl-Tyr carboxypeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of the Glu-Tyr bond to release the C-terminal tyrosine residue from the native tyrosinated tubulin. Inactive on Z-Glu-Tyr." [EC:3.4.17.17]
comment: This term was made obsolete because it represents a gene product.
synonym: "brain I carboxypeptidase activity" EXACT [EC:3.4.17.17]
synonym: "carboxypeptidase-tubulin activity" EXACT [EC:3.4.17.17]
synonym: "soluble carboxypeptidase activity" RELATED [EC:3.4.17.17]
synonym: "TTCPase activity" EXACT [EC:3.4.17.17]
synonym: "tubulin carboxypeptidase activity" EXACT [EC:3.4.17.17]
synonym: "tubulin-tyrosine carboxypeptidase activity" EXACT [EC:3.4.17.17]
synonym: "tubulinyl-Tyr carboxypeptidase activity" EXACT []
synonym: "tubulinyl-tyrosine carboxypeptidase activity" EXACT []
synonym: "tubulinyltyrosine carboxypeptidase activity" EXACT [EC:3.4.17.17]
synonym: "tyrosinotubulin carboxypeptidase activity" EXACT [EC:3.4.17.17]
synonym: "tyrosyltubulin carboxypeptidase activity" EXACT [EC:3.4.17.17]
xref: EC:3.4.17.17
xref: MetaCyc:3.4.17.17-RXN
is_obsolete: true
replaced_by: GO:0004181

[Term]
id: GO:0004190
name: aspartic-type endopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
subset: gosubset_prok
synonym: "aspartate protease activity" NARROW [GOC:mah, GOC:vw]
synonym: "aspartic endopeptidase activity" EXACT []
synonym: "aspartic protease activity" NARROW []
synonym: "aspartyl protease activity" NARROW []
synonym: "carboxyl protease activity" NARROW []
xref: EC:3.4.23
xref: Reactome:REACT_100150 "NEXT1 is cleaved to produce NICD1, Gallus gallus"
xref: Reactome:REACT_100746 "NEXT2 is cleaved to produce NICD2, Rattus norvegicus"
xref: Reactome:REACT_102828 "NEXT1 is cleaved to produce NICD1, Xenopus tropicalis"
xref: Reactome:REACT_103663 "NEXT4 is cleaved to produce NICD4, Bos taurus"
xref: Reactome:REACT_103855 "NEXT2 is cleaved to produce NICD2, Drosophila melanogaster"
xref: Reactome:REACT_106913 "NEXT4 is cleaved to produce NICD4, Mus musculus"
xref: Reactome:REACT_108687 "NEXT3 is cleaved to produce NICD3, Danio rerio"
xref: Reactome:REACT_108752 "NEXT4 is cleaved to produce NICD4, Canis familiaris"
xref: Reactome:REACT_110055 "NEXT2 is cleaved to produce NICD2, Xenopus tropicalis"
xref: Reactome:REACT_114839 "NEXT4 is cleaved to produce NICD4, Xenopus tropicalis"
xref: Reactome:REACT_114927 "NEXT3 is cleaved to produce NICD3, Drosophila melanogaster"
xref: Reactome:REACT_1306 "NEXT2 is cleaved to produce NICD2, Homo sapiens"
xref: Reactome:REACT_1784 "NEXT1 is cleaved to produce NICD1, Homo sapiens"
xref: Reactome:REACT_1803 "NEXT3 is cleaved to produce NICD3, Homo sapiens"
xref: Reactome:REACT_28604 "NEXT1 is cleaved to produce NICD1, Danio rerio"
xref: Reactome:REACT_29012 "NEXT4 is cleaved to produce NICD4, Sus scrofa"
xref: Reactome:REACT_29591 "NEXT4 is cleaved to produce NICD4, Rattus norvegicus"
xref: Reactome:REACT_30254 "NEXT3 is cleaved to produce NICD3, Bos taurus"
xref: Reactome:REACT_32331 "NEXT3 is cleaved to produce NICD3, Xenopus tropicalis"
xref: Reactome:REACT_34376 "NEXT1 is cleaved to produce NICD1, Drosophila melanogaster"
xref: Reactome:REACT_77061 "NEXT1 is cleaved to produce NICD1, Rattus norvegicus"
xref: Reactome:REACT_78562 "NEXT2 is cleaved to produce NICD2, Canis familiaris"
xref: Reactome:REACT_78689 "NEXT3 is cleaved to produce NICD3, Mus musculus"
xref: Reactome:REACT_80559 "NEXT2 is cleaved to produce NICD2, Mus musculus"
xref: Reactome:REACT_82242 "NEXT2 is cleaved to produce NICD2, Bos taurus"
xref: Reactome:REACT_82441 "NEXT1 is cleaved to produce NICD1, Taeniopygia guttata"
xref: Reactome:REACT_89773 "NEXT1 is cleaved to produce NICD1, Bos taurus"
xref: Reactome:REACT_89990 "NEXT3 is cleaved to produce NICD3, Canis familiaris"
xref: Reactome:REACT_93093 "NEXT2 is cleaved to produce NICD2, Gallus gallus"
xref: Reactome:REACT_93980 "NEXT2 is cleaved to produce NICD2, Sus scrofa"
xref: Reactome:REACT_95514 "NEXT1 is cleaved to produce NICD1, Canis familiaris"
xref: Reactome:REACT_96133 "NEXT2 is cleaved to produce NICD2, Danio rerio"
xref: Reactome:REACT_96159 "NEXT1 is cleaved to produce NICD1, Mus musculus"
xref: Reactome:REACT_965 "NEXT4 is cleaved to produce NICD4, Homo sapiens"
xref: Reactome:REACT_97765 "NEXT3 is cleaved to produce NICD3, Rattus norvegicus"
is_a: GO:0004175 ! endopeptidase activity
is_a: GO:0070001 ! aspartic-type peptidase activity

[Term]
id: GO:0004191
name: obsolete barrierpepsin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the selected cleavage of the Leu6-Lys7 bond in the pheromone alpha-mating factor." [EC:3.4.23.35]
comment: This term was made obsolete because it represents a gene product.
synonym: "Bar proteinase activity" NARROW [EC:3.4.23.35]
synonym: "barrier proteinase activity" EXACT [EC:3.4.23.35]
synonym: "barrierpepsin activity" EXACT []
synonym: "extracellular 'barrier' protein activity" RELATED [EC:3.4.23.35]
xref: EC:3.4.23.35
xref: MetaCyc:3.4.23.35-RXN
is_obsolete: true
replaced_by: GO:0004190

[Term]
id: GO:0004192
name: obsolete cathepsin D activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity similar to, but narrower than, that of pepsin A. Does not cleave the Gln4-His5 bond in the B chain of insulin." [EC:3.4.23.5]
comment: This term was made obsolete because it represents a gene product.
synonym: "cathepsin D activity" EXACT []
xref: EC:3.4.23.5
xref: MetaCyc:3.4.23.5-RXN
is_obsolete: true
replaced_by: GO:0004190

[Term]
id: GO:0004193
name: obsolete cathepsin E activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Similar to cathepsin D, but slightly broader specificity." [EC:3.4.23.34]
comment: This term was made obsolete because it represents a gene product.
synonym: "cathepsin D-like acid proteinase activity" EXACT [EC:3.4.23.34]
synonym: "cathepsin D-type proteinase activity" EXACT [EC:3.4.23.34]
synonym: "cathepsin E activity" EXACT []
synonym: "cathepsin E-like acid proteinase activity" EXACT [EC:3.4.23.34]
synonym: "EMAP" RELATED [EC:3.4.23.34]
synonym: "erythrocyte membrane aspartic proteinase activity" NARROW [EC:3.4.23.34]
synonym: "non-pepsin proteinase activity" EXACT [EC:3.4.23.34]
synonym: "slow-moving proteinase activity" RELATED [EC:3.4.23.34]
synonym: "SMP" RELATED [EC:3.4.23.34]
xref: EC:3.4.23.34
xref: MetaCyc:3.4.23.34-RXN
is_obsolete: true
replaced_by: GO:0004190

[Term]
id: GO:0004194
name: obsolete pepsin A activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves Phe1-Val2, Gln4-His5, Glu13-Ala14, Ala14-Leu15, Leu15-Tyr16, Tyr16-Leu17, Gly23-Phe24, Phe24-Phe25 and Phe25-Tyr26 bonds in the B chain of insulin." [EC:3.4.23.1]
comment: This term was made obsolete because it represents a gene product.
synonym: "elixir lactate of pepsin" RELATED [EC:3.4.23.1]
synonym: "fundus-pepsin" RELATED [EC:3.4.23.1]
synonym: "lactated pepsin" RELATED [EC:3.4.23.1]
synonym: "lactated pepsin elixir" RELATED [EC:3.4.23.1]
synonym: "P I" RELATED [EC:3.4.23.1]
synonym: "P II" RELATED [EC:3.4.23.1]
synonym: "pepsin A activity" EXACT []
synonym: "pepsin activity" BROAD [EC:3.4.23.1]
synonym: "pepsin D" RELATED [EC:3.4.23.1]
synonym: "pepsin fortior" RELATED [EC:3.4.23.1]
synonym: "pepsin R" RELATED [EC:3.4.23.1]
xref: EC:3.4.23.1
xref: MetaCyc:3.4.23.1-RXN
is_obsolete: true
replaced_by: GO:0004190

[Term]
id: GO:0004195
name: obsolete renin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of Leu-Xaa bond in angiotensinogen to generate angiotensin I." [EC:3.4.23.15]
comment: This term was made obsolete because it represents a gene product.
synonym: "angiotensin-forming enzyme activity" EXACT [EC:3.4.23.15]
synonym: "angiotensinogenase activity" EXACT [EC:3.4.23.15]
synonym: "renin activity" EXACT []
xref: EC:3.4.23.15
xref: MetaCyc:3.4.23.15-RXN
is_obsolete: true
replaced_by: GO:0004190

[Term]
id: GO:0004196
name: obsolete saccharopepsin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the degradation of gelatin; little activity on hemoglobin. Specificity on B chain of insulin more restricted than pepsin A; does not cleave Phe1-Val2, Gln4-His5 or Gly23-Phe24." [EC:3.4.23.25]
comment: This term was made obsolete because it represents a gene product.
synonym: "aspartic proteinase yscA" RELATED [EC:3.4.23.25]
synonym: "PRA" RELATED [EC:3.4.23.25]
synonym: "proteinase A" RELATED [EC:3.4.23.25]
synonym: "proteinase yscA" RELATED [EC:3.4.23.25]
synonym: "Saccharomyces aspartic proteinase activity" NARROW [EC:3.4.23.25]
synonym: "saccharomyces aspartic proteinase activity" EXACT [EC:3.4.23.25]
synonym: "saccharomyces cerevisiae aspartic proteinase A" RELATED [EC:3.4.23.25]
synonym: "saccharopepsin activity" EXACT []
synonym: "yeast endopeptidase A activity" NARROW [EC:3.4.23.25]
synonym: "yeast proteinase A" RELATED [EC:3.4.23.25]
xref: EC:3.4.23.25
xref: MetaCyc:3.4.23.25-RXN
is_obsolete: true
replaced_by: GO:0004190

[Term]
id: GO:0004197
name: cysteine-type endopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
subset: gosubset_prok
synonym: "caspase activity" NARROW [GOC:mtg_apoptosis]
synonym: "lysosomal cysteine-type endopeptidase" NARROW []
synonym: "metacaspase activity" NARROW [GOC:mtg_apoptosis]
synonym: "thiol endopeptidase activity" EXACT []
xref: EC:3.4.22
xref: Reactome:REACT_100050 "Caspase-mediated cleavage of plectin-1, Mus musculus"
xref: Reactome:REACT_100093 "Cleavage of Procaspase-7 by the apoptosome, Danio rerio"
xref: Reactome:REACT_100258 "Caspase-mediated cleavage of PKC theta, Bos taurus"
xref: Reactome:REACT_100371 "Caspase mediated cleavage of HIP-55, Rattus norvegicus"
xref: Reactome:REACT_100591 "Caspase mediated cleavage of C-IAP1, Danio rerio"
xref: Reactome:REACT_100749 "Caspase-mediated cleavage of vimentin at DSVD (85), Sus scrofa"
xref: Reactome:REACT_100786 "Caspase mediated cleavage of BAP31, Sus scrofa"
xref: Reactome:REACT_100806 "Caspase-mediated cleavage of E-Cadherin, Mus musculus"
xref: Reactome:REACT_101275 "Caspase-mediated cleavage of claspin, Bos taurus"
xref: Reactome:REACT_101388 "Caspase-mediated cleavage of Rock-1, Danio rerio"
xref: Reactome:REACT_101482 "Caspase-mediated cleavage of vimentin at TNLD (429), Taeniopygia guttata"
xref: Reactome:REACT_101496 "Caspase-mediated cleavage of Etk, Mus musculus"
xref: Reactome:REACT_101535 "Caspase mediated cleavage of C-IAP1, Xenopus tropicalis"
xref: Reactome:REACT_101617 "Caspase-mediated cleavage of GAS2, Danio rerio"
xref: Reactome:REACT_102211 "Caspase-mediated cleavage of Desmoglein 2, Rattus norvegicus"
xref: Reactome:REACT_102224 "Caspase-mediated cleavage of Lamin B1, Bos taurus"
xref: Reactome:REACT_102308 "Caspase mediated cleavage of HIP-55, Sus scrofa"
xref: Reactome:REACT_102448 "Cleavage of Procaspase-9 to Caspase-9, Gallus gallus"
xref: Reactome:REACT_102624 "Caspase mediated cleavage of C-IAP1, Bos taurus"
xref: Reactome:REACT_102731 "Caspase mediated cleavage of beta-catenin, Mus musculus"
xref: Reactome:REACT_102903 "Caspase-mediated cleavage of FADK 1, Canis familiaris"
xref: Reactome:REACT_103130 "Cleavage of Procaspase-7 by the apoptosome, Xenopus tropicalis"
xref: Reactome:REACT_103265 "Cleavage of Satb1, Taeniopygia guttata"
xref: Reactome:REACT_103288 "Caspase-mediated cleavage of Lamin B1, Xenopus tropicalis"
xref: Reactome:REACT_103478 "Caspase mediated cleavage of APC, Danio rerio"
xref: Reactome:REACT_103480 "Caspase-mediated cleavage of Tau, Sus scrofa"
xref: Reactome:REACT_103527 "Cleavage of PAK-2 at 212, Sus scrofa"
xref: Reactome:REACT_103538 "Caspase mediated cleavage of alpha-II-Fodrin, Gallus gallus"
xref: Reactome:REACT_103796 "Caspase-mediated cleavage of Desmoglein 3, Taeniopygia guttata"
xref: Reactome:REACT_103879 "Cleavage of Satb1, Gallus gallus"
xref: Reactome:REACT_103993 "Cleavage of PAK-2 at 212, Mus musculus"
xref: Reactome:REACT_103997 "Caspase-mediated cleavage of plectin-1, Danio rerio"
xref: Reactome:REACT_104056 "Caspase mediated cleavage of APC, Taeniopygia guttata"
xref: Reactome:REACT_104095 "Caspase-mediated cleavage of alpha adducin, Mus musculus"
xref: Reactome:REACT_104234 "Caspase-mediated cleavage of Desmoglein 1, Mus musculus"
xref: Reactome:REACT_104249 "Caspase mediated cleavage of alpha-II-Fodrin, Danio rerio"
xref: Reactome:REACT_104338 "Legumain degrades DBP, Mus musculus"
xref: Reactome:REACT_104344 "Caspase-mediated cleavage of Tau, Gallus gallus"
xref: Reactome:REACT_104391 "Cleavage of Procaspase-7 by the apoptosome, Taeniopygia guttata"
xref: Reactome:REACT_104407 "Caspase-mediated cleavage of Lamin B1, Danio rerio"
xref: Reactome:REACT_104493 "Caspase-mediated cleavage of E-Cadherin, Rattus norvegicus"
xref: Reactome:REACT_104700 "Caspase 3-mediated cleavage of PKC delta, Canis familiaris"
xref: Reactome:REACT_104895 "Caspase-8 activates BID by cleavage, Mus musculus"
xref: Reactome:REACT_105045 "Caspase-mediated cleavage of E-Cadherin, Gallus gallus"
xref: Reactome:REACT_105170 "Caspase mediated cleavage of alpha-II-Fodrin, Mus musculus"
xref: Reactome:REACT_105481 "Caspase-mediated cleavage of alpha adducin, Gallus gallus"
xref: Reactome:REACT_105581 "Caspase-mediated cleavage of plectin-1, Bos taurus"
xref: Reactome:REACT_105957 "Caspase-mediated cleavage of Rock-1, Rattus norvegicus"
xref: Reactome:REACT_105958 "Caspase-mediated cleavage of MASK, Mus musculus"
xref: Reactome:REACT_106680 "Caspase-mediated cleavage of GAS2, Rattus norvegicus"
xref: Reactome:REACT_107019 "Caspase mediated cleavage of beta-catenin, Taeniopygia guttata"
xref: Reactome:REACT_107128 "Cleavage of Satb1, Danio rerio"
xref: Reactome:REACT_107302 "Caspase-mediated cleavage of Rock-1, Bos taurus"
xref: Reactome:REACT_107511 "Caspase-mediated cleavage of Lamin A, Sus scrofa"
xref: Reactome:REACT_107529 "Caspase-mediated cleavage of Lamin B1, Sus scrofa"
xref: Reactome:REACT_107629 "Caspase-mediated cleavage of Lamin A, Drosophila melanogaster"
xref: Reactome:REACT_107758 "Caspase mediated cleavage of beta-catenin, Danio rerio"
xref: Reactome:REACT_107853 "Caspase-mediated cleavage of GAS2, Bos taurus"
xref: Reactome:REACT_108026 "Caspase mediated cleavage of vimentin at IDVD (259), Taeniopygia guttata"
xref: Reactome:REACT_108198 "Caspase-mediated cleavage of Lamin B1, Rattus norvegicus"
xref: Reactome:REACT_108258 "Caspase-mediated cleavage of FADK 1, Taeniopygia guttata"
xref: Reactome:REACT_108537 "Caspase-mediated cleavage of gelsolin, Mus musculus"
xref: Reactome:REACT_108621 "Caspase mediated cleavage of beta-catenin, Sus scrofa"
xref: Reactome:REACT_108783 "Caspase mediated cleavage of vimentin at IDVD (259), Danio rerio"
xref: Reactome:REACT_108820 "Caspase-mediated cleavage of MASK, Canis familiaris"
xref: Reactome:REACT_108938 "Caspase-mediated cleavage of MASK, Rattus norvegicus"
xref: Reactome:REACT_108946 "Caspase-mediated cleavage of Lamin A, Gallus gallus"
xref: Reactome:REACT_109026 "Caspase-mediated cleavage of PKC theta, Sus scrofa"
xref: Reactome:REACT_109078 "Caspase-mediated cleavage of MASK, Taeniopygia guttata"
xref: Reactome:REACT_109269 "Caspase-mediated cleavage of Etk, Canis familiaris"
xref: Reactome:REACT_109374 "Caspase-mediated cleavage of Desmoglein 1, Danio rerio"
xref: Reactome:REACT_109414 "Caspase mediated cleavage of APC, Xenopus tropicalis"
xref: Reactome:REACT_109547 "Caspase-mediated cleavage of vimentin at DSVD (85), Taeniopygia guttata"
xref: Reactome:REACT_109908 "Activation of caspase-3, Canis familiaris"
xref: Reactome:REACT_110043 "Caspase-mediated cleavage of vimentin at TNLD (429), Danio rerio"
xref: Reactome:REACT_110086 "Caspase-mediated cleavage of Desmoglein 2, Mus musculus"
xref: Reactome:REACT_110544 "Caspase mediated cleavage of BAP31, Canis familiaris"
xref: Reactome:REACT_110842 "Caspase-mediated cleavage of vimentin at DSVD (85), Xenopus tropicalis"
xref: Reactome:REACT_111140 "Antigen processing by cathepsin S in endosoytic vesicle, Homo sapiens"
xref: Reactome:REACT_111954 "Cleavage of Procaspase-7 by the apoptosome, Rattus norvegicus"
xref: Reactome:REACT_112287 "Activation of caspase-3, Xenopus tropicalis"
xref: Reactome:REACT_112363 "Cleavage of Procaspase-9 to Caspase-9, Sus scrofa"
xref: Reactome:REACT_112407 "Caspase mediated cleavage of vimentin at IDVD (259), Caenorhabditis elegans"
xref: Reactome:REACT_112426 "Caspase-mediated cleavage of Desmoglein 1, Xenopus tropicalis"
xref: Reactome:REACT_112597 "Caspase-mediated cleavage of Desmoglein 3, Xenopus tropicalis"
xref: Reactome:REACT_112616 "Cleavage of Procaspase-7 by the apoptosome, Sus scrofa"
xref: Reactome:REACT_112859 "Cleavage of Procaspase-7 by the apoptosome, Canis familiaris"
xref: Reactome:REACT_113141 "Cleavage of Procaspase-9 to Caspase-9, Canis familiaris"
xref: Reactome:REACT_113588 "Caspase-mediated cleavage of Desmoglein 2, Xenopus tropicalis"
xref: Reactome:REACT_114270 "Caspase mediated cleavage of alpha-II-Fodrin, Xenopus tropicalis"
xref: Reactome:REACT_114571 "Cleavage of Procaspase-7 by the apoptosome, Bos taurus"
xref: Reactome:REACT_114579 "Cleavage of Procaspase-9 to Caspase-9, Rattus norvegicus"
xref: Reactome:REACT_114638 "Caspase-mediated cleavage of Acinus, Xenopus tropicalis"
xref: Reactome:REACT_114872 "Caspase mediated cleavage of BAP31, Caenorhabditis elegans"
xref: Reactome:REACT_115070 "Caspase-mediated cleavage of Rock-1, Canis familiaris"
xref: Reactome:REACT_115318 "Caspase-mediated cleavage of plectin-1, Taeniopygia guttata"
xref: Reactome:REACT_115379 "Cleavage of Procaspase-9 to Caspase-9, Bos taurus"
xref: Reactome:REACT_11997 "Caspase-mediated cleavage of Desmoglein 1, Homo sapiens"
xref: Reactome:REACT_12004 "Caspase-mediated cleavage of GAS2, Homo sapiens"
xref: Reactome:REACT_12012 "Caspase mediated cleavage of APC, Homo sapiens"
xref: Reactome:REACT_12014 "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha, Homo sapiens"
xref: Reactome:REACT_12021 "Caspase-mediated cleavage of FADK 1, Homo sapiens"
xref: Reactome:REACT_12022 "Caspase mediated cleavage of beta-catenin, Homo sapiens"
xref: Reactome:REACT_12024 "Caspase mediated cleavage of alpha-II-Fodrin, Homo sapiens"
xref: Reactome:REACT_12025 "Caspase mediated cleavage of HIP-55, Homo sapiens"
xref: Reactome:REACT_12044 "Caspase-mediated cleavage of alpha adducin, Homo sapiens"
xref: Reactome:REACT_12045 "Caspase mediated cleavage of C-IAP1, Homo sapiens"
xref: Reactome:REACT_12072 "Caspase-mediated cleavage of E-Cadherin, Homo sapiens"
xref: Reactome:REACT_12082 "Caspase-mediated cleavage of Desmoglein 3, Homo sapiens"
xref: Reactome:REACT_12404 "Cleavage of DFF45 (224) by caspase-3, Homo sapiens"
xref: Reactome:REACT_12450 "Caspase-mediated cleavage of Acinus, Homo sapiens"
xref: Reactome:REACT_12471 "Caspase 3-mediated cleavage of PKC delta, Homo sapiens"
xref: Reactome:REACT_12531 "Caspase-mediated cleavage of Rock-1, Homo sapiens"
xref: Reactome:REACT_12544 "Caspase 3-mediated cleavage of DFF45 (117), Homo sapiens"
xref: Reactome:REACT_12638 "Caspase-mediated cleavage of PKC theta, Homo sapiens"
xref: Reactome:REACT_1320 "Caspase-8 activates BID by cleavage, Homo sapiens"
xref: Reactome:REACT_13414 "Caspase-mediated cleavage of Tau, Homo sapiens"
xref: Reactome:REACT_13417 "Caspase-mediated cleavage of Etk, Homo sapiens"
xref: Reactome:REACT_13418 "Caspase-mediated cleavage of plakophilin-1, Homo sapiens"
xref: Reactome:REACT_13428 "Caspase-mediated cleavage of vimentin at DSVD (85), Homo sapiens"
xref: Reactome:REACT_13466 "Cleavage of PAK-2 at 212, Oryctolagus cuniculus"
xref: Reactome:REACT_13468 "Caspase-mediated cleavage of MST3, Homo sapiens"
xref: Reactome:REACT_13476 "Caspase-mediated cleavage of Lamin A, Homo sapiens"
xref: Reactome:REACT_13484 "Caspase-mediated cleavage of Lamin B1, Homo sapiens"
xref: Reactome:REACT_13489 "Caspase mediated cleavage of vimentin at IDVD (259), Homo sapiens"
xref: Reactome:REACT_13519 "Caspase-mediated cleavage of vimentin at TNLD (429), Homo sapiens"
xref: Reactome:REACT_13522 "Caspase-mediated cleavage of plectin-1, Homo sapiens"
xref: Reactome:REACT_13549 "Caspase-mediated cleavage of occludin, Homo sapiens"
xref: Reactome:REACT_13554 "Caspase mediated cleavage of BAP31, Homo sapiens"
xref: Reactome:REACT_13587 "Caspase-mediated cleavage of Z0-1, Homo sapiens"
xref: Reactome:REACT_13598 "Caspase-mediated cleavage of Desmoglein 2, Homo sapiens"
xref: Reactome:REACT_13605 "Caspase-mediated cleavage of Desmoplakin, Homo sapiens"
xref: Reactome:REACT_13636 "Caspase-mediated cleavage of MASK, Homo sapiens"
xref: Reactome:REACT_13652 "Caspase-mediated cleavage of claspin, Homo sapiens"
xref: Reactome:REACT_13664 "Legumain degrades DBP, Homo sapiens"
xref: Reactome:REACT_13747 "Cleavage of PAK-2 at 212, Homo sapiens"
xref: Reactome:REACT_13795 "Caspase-mediated cleavage of gelsolin, Homo sapiens"
xref: Reactome:REACT_13813 "Caspase-mediated cleavage of Z0-2, Homo sapiens"
xref: Reactome:REACT_2116 "Cleavage of Procaspase-9 to Caspase-9, Homo sapiens"
xref: Reactome:REACT_2165 "Cleavage of Procaspase-7 by the apoptosome, Homo sapiens"
xref: Reactome:REACT_22184 "Caspase cleavage of UNC5A, Homo sapiens"
xref: Reactome:REACT_22225 "Cleavage of Satb1, Homo sapiens"
xref: Reactome:REACT_22343 "Caspase cleavage of UNC5B, Homo sapiens"
xref: Reactome:REACT_22367 "Caspase cleavage of Unc5h1, Mus musculus"
xref: Reactome:REACT_22412 "Activation of caspase-3, Homo sapiens"
xref: Reactome:REACT_22420 "Caspase cleavage of Unc5h2, Mus musculus"
xref: Reactome:REACT_22440 "Caspase cleavage of DCC, Homo sapiens"
xref: Reactome:REACT_24999 "Processing of caspases, Homo sapiens"
xref: Reactome:REACT_28312 "Caspase-mediated cleavage of PKC theta, Rattus norvegicus"
xref: Reactome:REACT_28479 "Caspase-mediated cleavage of Etk, Bos taurus"
xref: Reactome:REACT_28628 "Caspase-mediated cleavage of alpha adducin, Canis familiaris"
xref: Reactome:REACT_28846 "Caspase-mediated cleavage of Acinus, Mus musculus"
xref: Reactome:REACT_28869 "Cleavage of Procaspase-7 by the apoptosome, Gallus gallus"
xref: Reactome:REACT_29115 "Caspase-8 activates BID by cleavage, Canis familiaris"
xref: Reactome:REACT_29150 "Caspase mediated cleavage of vimentin at IDVD (259), Canis familiaris"
xref: Reactome:REACT_29160 "Caspase 3-mediated cleavage of DFF45 (117), Sus scrofa"
xref: Reactome:REACT_29351 "Cleavage of Procaspase-9 to Caspase-9, Danio rerio"
xref: Reactome:REACT_29430 "Caspase-mediated cleavage of claspin, Canis familiaris"
xref: Reactome:REACT_29547 "Caspase mediated cleavage of HIP-55, Bos taurus"
xref: Reactome:REACT_29647 "Caspase-mediated cleavage of claspin, Gallus gallus"
xref: Reactome:REACT_29743 "Caspase-mediated cleavage of GAS2, Taeniopygia guttata"
xref: Reactome:REACT_29821 "Caspase-mediated cleavage of Lamin B1, Canis familiaris"
xref: Reactome:REACT_30047 "Caspase mediated cleavage of APC, Mus musculus"
xref: Reactome:REACT_30276 "Legumain degrades DBP, Gallus gallus"
xref: Reactome:REACT_30300 "Caspase mediated cleavage of APC, Sus scrofa"
xref: Reactome:REACT_30513 "Caspase mediated cleavage of APC, Rattus norvegicus"
xref: Reactome:REACT_30561 "Legumain degrades DBP, Canis familiaris"
xref: Reactome:REACT_30860 "Caspase-mediated cleavage of FADK 1, Danio rerio"
xref: Reactome:REACT_31037 "Activation of caspase-3, Danio rerio"
xref: Reactome:REACT_31043 "Caspase mediated cleavage of beta-catenin, Canis familiaris"
xref: Reactome:REACT_31510 "Caspase-mediated cleavage of gelsolin, Bos taurus"
xref: Reactome:REACT_31594 "Caspase mediated cleavage of beta-catenin, Xenopus tropicalis"
xref: Reactome:REACT_31912 "Caspase 3-mediated cleavage of PKC delta, Taeniopygia guttata"
xref: Reactome:REACT_31993 "Cleavage of PAK-2 at 212, Danio rerio"
xref: Reactome:REACT_32081 "Caspase-mediated cleavage of E-Cadherin, Canis familiaris"
xref: Reactome:REACT_32092 "Caspase mediated cleavage of C-IAP1, Canis familiaris"
xref: Reactome:REACT_32303 "Cleavage of Satb1, Canis familiaris"
xref: Reactome:REACT_32343 "Legumain degrades DBP, Danio rerio"
xref: Reactome:REACT_32649 "Caspase mediated cleavage of vimentin at IDVD (259), Mus musculus"
xref: Reactome:REACT_32982 "Caspase-mediated cleavage of Desmoglein 3, Rattus norvegicus"
xref: Reactome:REACT_33284 "Caspase mediated cleavage of HIP-55, Xenopus tropicalis"
xref: Reactome:REACT_33786 "Caspase-mediated cleavage of Desmoglein 2, Danio rerio"
xref: Reactome:REACT_33971 "Caspase-mediated cleavage of FADK 1, Rattus norvegicus"
xref: Reactome:REACT_34082 "Caspase mediated cleavage of alpha-II-Fodrin, Taeniopygia guttata"
xref: Reactome:REACT_34279 "Caspase-mediated cleavage of Desmoglein 2, Taeniopygia guttata"
xref: Reactome:REACT_34342 "Caspase mediated cleavage of vimentin at IDVD (259), Rattus norvegicus"
xref: Reactome:REACT_34469 "Caspase-mediated cleavage of MASK, Danio rerio"
xref: Reactome:REACT_34743 "Cleavage of Procaspase-9 to Caspase-9, Xenopus tropicalis"
xref: Reactome:REACT_34768 "Caspase-mediated cleavage of plectin-1, Rattus norvegicus"
xref: Reactome:REACT_34770 "Caspase 3-mediated cleavage of PKC delta, Bos taurus"
xref: Reactome:REACT_40493 "Caspase 3-mediated cleavage of PKC delta, Mus musculus"
xref: Reactome:REACT_45490 "Caspase 3-mediated cleavage of DFF45 (117), Canis familiaris"
xref: Reactome:REACT_65200 "Caspase mediated cleavage of HIP-55, Mus musculus"
xref: Reactome:REACT_66649 "Caspase-mediated cleavage of FADK 1, Gallus gallus"
xref: Reactome:REACT_69471 "Caspase-mediated cleavage of Lamin B1, Mus musculus"
xref: Reactome:REACT_77064 "Cleavage of DFF45 (224) by caspase-3, Sus scrofa"
xref: Reactome:REACT_77154 "Caspase-mediated cleavage of Lamin A, Bos taurus"
xref: Reactome:REACT_77197 "Caspase 3-mediated cleavage of DFF45 (117), Taeniopygia guttata"
xref: Reactome:REACT_77210 "Caspase-mediated cleavage of FADK 1, Sus scrofa"
xref: Reactome:REACT_77248 "Cleavage of PAK-2 at 212, Taeniopygia guttata"
xref: Reactome:REACT_77301 "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha, Taeniopygia guttata"
xref: Reactome:REACT_77309 "Caspase mediated cleavage of HIP-55, Canis familiaris"
xref: Reactome:REACT_77343 "Caspase-mediated cleavage of Acinus, Sus scrofa"
xref: Reactome:REACT_77434 "Caspase 3-mediated cleavage of DFF45 (117), Gallus gallus"
xref: Reactome:REACT_77678 "Caspase-mediated cleavage of Rock-1, Mus musculus"
xref: Reactome:REACT_77795 "Cleavage of Satb1, Xenopus tropicalis"
xref: Reactome:REACT_77916 "Caspase-mediated cleavage of vimentin at TNLD (429), Bos taurus"
xref: Reactome:REACT_77921 "Caspase mediated cleavage of APC, Bos taurus"
xref: Reactome:REACT_78072 "Cleavage of DFF45 (224) by caspase-3, Xenopus tropicalis"
xref: Reactome:REACT_78179 "Caspase-8 activates BID by cleavage, Rattus norvegicus"
xref: Reactome:REACT_78180 "Caspase-mediated cleavage of Lamin B1, Gallus gallus"
xref: Reactome:REACT_78322 "Caspase mediated cleavage of C-IAP1, Taeniopygia guttata"
xref: Reactome:REACT_78407 "Caspase mediated cleavage of beta-catenin, Rattus norvegicus"
xref: Reactome:REACT_78676 "Caspase-mediated cleavage of Rock-1, Xenopus tropicalis"
xref: Reactome:REACT_78896 "Caspase-mediated cleavage of Lamin A, Canis familiaris"
xref: Reactome:REACT_78931 "Caspase-mediated cleavage of E-Cadherin, Taeniopygia guttata"
xref: Reactome:REACT_78958 "Caspase 3-mediated cleavage of PKC delta, Xenopus tropicalis"
xref: Reactome:REACT_79257 "Caspase-mediated cleavage of claspin, Xenopus tropicalis"
xref: Reactome:REACT_79283 "Caspase-mediated cleavage of Acinus, Bos taurus"
xref: Reactome:REACT_79470 "Caspase mediated cleavage of BAP31, Rattus norvegicus"
xref: Reactome:REACT_79514 "Cleavage of Satb1, Bos taurus"
xref: Reactome:REACT_79541 "Caspase-mediated cleavage of vimentin at DSVD (85), Canis familiaris"
xref: Reactome:REACT_79778 "Caspase-mediated cleavage of vimentin at TNLD (429), Rattus norvegicus"
xref: Reactome:REACT_79895 "Caspase-mediated cleavage of vimentin at TNLD (429), Xenopus tropicalis"
xref: Reactome:REACT_79950 "Caspase mediated cleavage of APC, Canis familiaris"
xref: Reactome:REACT_80378 "Caspase mediated cleavage of HIP-55, Gallus gallus"
xref: Reactome:REACT_80953 "Caspase-mediated cleavage of Desmoglein 3, Mus musculus"
xref: Reactome:REACT_80998 "Caspase mediated cleavage of C-IAP1, Mus musculus"
xref: Reactome:REACT_81124 "Caspase-mediated cleavage of Desmoglein 2, Gallus gallus"
xref: Reactome:REACT_81156 "Caspase-mediated cleavage of vimentin at TNLD (429), Mus musculus"
xref: Reactome:REACT_81371 "Caspase-mediated cleavage of vimentin at DSVD (85), Mus musculus"
xref: Reactome:REACT_81496 "Caspase-mediated cleavage of GAS2, Canis familiaris"
xref: Reactome:REACT_81521 "Caspase 3-mediated cleavage of DFF45 (117), Mus musculus"
xref: Reactome:REACT_81570 "Caspase-mediated cleavage of Tau, Mus musculus"
xref: Reactome:REACT_81606 "Caspase mediated cleavage of alpha-II-Fodrin, Bos taurus"
xref: Reactome:REACT_81720 "Cleavage of Procaspase-9 to Caspase-9, Mus musculus"
xref: Reactome:REACT_81816 "Cleavage of DFF45 (224) by caspase-3, Danio rerio"
xref: Reactome:REACT_81951 "Caspase mediated cleavage of BAP31, Danio rerio"
xref: Reactome:REACT_82352 "Cleavage of Satb1, Sus scrofa"
xref: Reactome:REACT_82992 "Caspase-mediated cleavage of MASK, Gallus gallus"
xref: Reactome:REACT_83002 "Cleavage of Procaspase-9 to Caspase-9, Taeniopygia guttata"
xref: Reactome:REACT_83106 "Caspase-mediated cleavage of FADK 1, Mus musculus"
xref: Reactome:REACT_83519 "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha, Mus musculus"
xref: Reactome:REACT_83624 "Caspase-mediated cleavage of MASK, Xenopus tropicalis"
xref: Reactome:REACT_83683 "Caspase-mediated cleavage of vimentin at TNLD (429), Gallus gallus"
xref: Reactome:REACT_84133 "Caspase-mediated cleavage of plectin-1, Canis familiaris"
xref: Reactome:REACT_84494 "Caspase-mediated cleavage of Desmoglein 2, Canis familiaris"
xref: Reactome:REACT_84645 "Caspase 3-mediated cleavage of DFF45 (117), Rattus norvegicus"
xref: Reactome:REACT_84845 "Cleavage of PAK-2 at 212, Canis familiaris"
xref: Reactome:REACT_84872 "Caspase-mediated cleavage of Acinus, Danio rerio"
xref: Reactome:REACT_84905 "Caspase-8 activates BID by cleavage, Taeniopygia guttata"
xref: Reactome:REACT_84967 "Caspase-mediated cleavage of Desmoglein 1, Canis familiaris"
xref: Reactome:REACT_84971 "Cleavage of PAK-2 at 212, Xenopus tropicalis"
xref: Reactome:REACT_85027 "Caspase-mediated cleavage of Tau, Rattus norvegicus"
xref: Reactome:REACT_85032 "Caspase mediated cleavage of HIP-55, Danio rerio"
xref: Reactome:REACT_85270 "Caspase mediated cleavage of BAP31, Mus musculus"
xref: Reactome:REACT_85285 "Caspase-mediated cleavage of alpha adducin, Sus scrofa"
xref: Reactome:REACT_85370 "Caspase-mediated cleavage of vimentin at DSVD (85), Bos taurus"
xref: Reactome:REACT_85432 "Cleavage of PAK-2 at 212, Gallus gallus"
xref: Reactome:REACT_85447 "Caspase-mediated cleavage of Tau, Canis familiaris"
xref: Reactome:REACT_85559 "Caspase-mediated cleavage of Desmoglein 1, Gallus gallus"
xref: Reactome:REACT_85681 "Caspase-mediated cleavage of alpha adducin, Xenopus tropicalis"
xref: Reactome:REACT_85820 "Caspase 3-mediated cleavage of PKC delta, Rattus norvegicus"
xref: Reactome:REACT_85958 "Caspase-mediated cleavage of Etk, Gallus gallus"
xref: Reactome:REACT_86010 "Caspase-mediated cleavage of Desmoglein 3, Gallus gallus"
xref: Reactome:REACT_86094 "Caspase-mediated cleavage of vimentin at TNLD (429), Sus scrofa"
xref: Reactome:REACT_86100 "Caspase-mediated cleavage of Rock-1, Taeniopygia guttata"
xref: Reactome:REACT_86150 "Caspase mediated cleavage of alpha-II-Fodrin, Rattus norvegicus"
xref: Reactome:REACT_86362 "Caspase-mediated cleavage of MASK, Bos taurus"
xref: Reactome:REACT_86384 "Caspase-mediated cleavage of PKC theta, Mus musculus"
xref: Reactome:REACT_86398 "Caspase mediated cleavage of C-IAP1, Rattus norvegicus"
xref: Reactome:REACT_86436 "Caspase-mediated cleavage of claspin, Rattus norvegicus"
xref: Reactome:REACT_86545 "Caspase mediated cleavage of vimentin at IDVD (259), Sus scrofa"
xref: Reactome:REACT_86791 "Caspase-mediated cleavage of Tau, Taeniopygia guttata"
xref: Reactome:REACT_86903 "Caspase mediated cleavage of HIP-55, Taeniopygia guttata"
xref: Reactome:REACT_86932 "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha, Canis familiaris"
xref: Reactome:REACT_87309 "Legumain degrades DBP, Rattus norvegicus"
xref: Reactome:REACT_87440 "Caspase-mediated cleavage of vimentin at DSVD (85), Gallus gallus"
xref: Reactome:REACT_87658 "Caspase mediated cleavage of vimentin at IDVD (259), Bos taurus"
xref: Reactome:REACT_87895 "Caspase-mediated cleavage of claspin, Mus musculus"
xref: Reactome:REACT_87973 "Caspase-mediated cleavage of FADK 1, Xenopus tropicalis"
xref: Reactome:REACT_88107 "Caspase-mediated cleavage of claspin, Danio rerio"
xref: Reactome:REACT_88165 "Cleavage of DFF45 (224) by caspase-3, Gallus gallus"
xref: Reactome:REACT_88929 "Caspase-8 activates BID by cleavage, Sus scrofa"
xref: Reactome:REACT_89449 "Caspase-mediated cleavage of alpha adducin, Taeniopygia guttata"
xref: Reactome:REACT_89531 "Caspase 3-mediated cleavage of PKC delta, Danio rerio"
xref: Reactome:REACT_89573 "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha, Rattus norvegicus"
xref: Reactome:REACT_89708 "Cleavage of DFF45 (224) by caspase-3, Rattus norvegicus"
xref: Reactome:REACT_90001 "Caspase-mediated cleavage of FADK 1, Bos taurus"
xref: Reactome:REACT_90025 "Caspase-mediated cleavage of PKC theta, Taeniopygia guttata"
xref: Reactome:REACT_90026 "Caspase-mediated cleavage of vimentin at DSVD (85), Danio rerio"
xref: Reactome:REACT_90780 "Cleavage of Procaspase-7 by the apoptosome, Mus musculus"
xref: Reactome:REACT_90840 "Caspase-mediated cleavage of Desmoglein 3, Danio rerio"
xref: Reactome:REACT_90898 "Caspase-mediated cleavage of Lamin A, Danio rerio"
xref: Reactome:REACT_91339 "Cleavage of Satb1, Rattus norvegicus"
xref: Reactome:REACT_91358 "Caspase 3-mediated cleavage of DFF45 (117), Xenopus tropicalis"
xref: Reactome:REACT_91380 "Caspase-mediated cleavage of gelsolin, Canis familiaris"
xref: Reactome:REACT_91436 "Caspase-mediated cleavage of Lamin A, Xenopus tropicalis"
xref: Reactome:REACT_91694 "Caspase-mediated cleavage of claspin, Sus scrofa"
xref: Reactome:REACT_91811 "Caspase-mediated cleavage of claspin, Taeniopygia guttata"
xref: Reactome:REACT_91825 "Caspase-mediated cleavage of GAS2, Mus musculus"
xref: Reactome:REACT_91992 "Caspase-mediated cleavage of Lamin B1, Taeniopygia guttata"
xref: Reactome:REACT_92095 "Cleavage of DFF45 (224) by caspase-3, Taeniopygia guttata"
xref: Reactome:REACT_92317 "Caspase mediated cleavage of alpha-II-Fodrin, Sus scrofa"
xref: Reactome:REACT_92549 "Caspase-mediated cleavage of Acinus, Rattus norvegicus"
xref: Reactome:REACT_92604 "Caspase mediated cleavage of BAP31, Bos taurus"
xref: Reactome:REACT_92733 "Caspase-mediated cleavage of E-Cadherin, Danio rerio"
xref: Reactome:REACT_93115 "Caspase-mediated cleavage of vimentin at TNLD (429), Canis familiaris"
xref: Reactome:REACT_93215 "Caspase-mediated cleavage of gelsolin, Rattus norvegicus"
xref: Reactome:REACT_93489 "Caspase-mediated cleavage of Acinus, Canis familiaris"
xref: Reactome:REACT_93620 "Caspase-mediated cleavage of E-Cadherin, Bos taurus"
xref: Reactome:REACT_93838 "Cleavage of DFF45 (224) by caspase-3, Bos taurus"
xref: Reactome:REACT_93845 "Caspase-mediated cleavage of Desmoglein 1, Rattus norvegicus"
xref: Reactome:REACT_93876 "Caspase-mediated cleavage of Tau, Danio rerio"
xref: Reactome:REACT_94219 "Cleavage of DFF45 (224) by caspase-3, Canis familiaris"
xref: Reactome:REACT_94280 "Caspase-mediated cleavage of Desmoglein 1, Taeniopygia guttata"
xref: Reactome:REACT_94301 "Caspase-8 activates BID by cleavage, Gallus gallus"
xref: Reactome:REACT_94351 "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha, Danio rerio"
xref: Reactome:REACT_94538 "Caspase 3-mediated cleavage of PKC delta, Gallus gallus"
xref: Reactome:REACT_94598 "Caspase 3-mediated cleavage of DFF45 (117), Bos taurus"
xref: Reactome:REACT_94641 "Caspase-mediated cleavage of alpha adducin, Rattus norvegicus"
xref: Reactome:REACT_94673 "Caspase-8 activates BID by cleavage, Bos taurus"
xref: Reactome:REACT_94680 "Caspase-mediated cleavage of Tau, Bos taurus"
xref: Reactome:REACT_95121 "Caspase-mediated cleavage of GAS2, Gallus gallus"
xref: Reactome:REACT_95172 "Caspase mediated cleavage of beta-catenin, Gallus gallus"
xref: Reactome:REACT_95220 "Caspase-mediated cleavage of Tau, Xenopus tropicalis"
xref: Reactome:REACT_95222 "Caspase-mediated cleavage of Desmoglein 3, Canis familiaris"
xref: Reactome:REACT_95242 "Caspase mediated cleavage of alpha-II-Fodrin, Canis familiaris"
xref: Reactome:REACT_95283 "Caspase-mediated cleavage of alpha adducin, Bos taurus"
xref: Reactome:REACT_95420 "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha, Bos taurus"
xref: Reactome:REACT_95652 "Caspase mediated cleavage of APC, Gallus gallus"
xref: Reactome:REACT_95884 "Caspase mediated cleavage of beta-catenin, Bos taurus"
xref: Reactome:REACT_95944 "Caspase-mediated cleavage of PKC theta, Canis familiaris"
xref: Reactome:REACT_95948 "Caspase-mediated cleavage of Rock-1, Gallus gallus"
xref: Reactome:REACT_96025 "Caspase-mediated cleavage of GAS2, Xenopus tropicalis"
xref: Reactome:REACT_96048 "Caspase 3-mediated cleavage of DFF45 (117), Danio rerio"
xref: Reactome:REACT_96146 "Caspase-mediated cleavage of PKC theta, Gallus gallus"
xref: Reactome:REACT_96219 "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha, Xenopus tropicalis"
xref: Reactome:REACT_96672 "Caspase-mediated cleavage of gelsolin, Danio rerio"
xref: Reactome:REACT_96721 "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha, Gallus gallus"
xref: Reactome:REACT_96744 "Caspase-mediated cleavage of vimentin at DSVD (85), Rattus norvegicus"
xref: Reactome:REACT_96941 "Cleavage of Satb1, Mus musculus"
xref: Reactome:REACT_97519 "Cleavage of PAK-2 at 212, Rattus norvegicus"
xref: Reactome:REACT_97541 "Caspase-mediated cleavage of PKC theta, Xenopus tropicalis"
xref: Reactome:REACT_97621 "Caspase mediated cleavage of vimentin at IDVD (259), Gallus gallus"
xref: Reactome:REACT_97639 "Caspase-mediated cleavage of Lamin B1, Drosophila melanogaster"
xref: Reactome:REACT_97875 "Legumain degrades DBP, Xenopus tropicalis"
xref: Reactome:REACT_97995 "Caspase-mediated cleavage of Lamin A, Taeniopygia guttata"
xref: Reactome:REACT_98036 "Activation of caspase-3, Rattus norvegicus"
xref: Reactome:REACT_98139 "Caspase-mediated cleavage of Desmoglein 3, Bos taurus"
xref: Reactome:REACT_98180 "Cleavage of DFF45 (224) by caspase-3, Mus musculus"
xref: Reactome:REACT_98289 "Caspase-mediated cleavage of Lamin A, Mus musculus"
xref: Reactome:REACT_98423 "Caspase-mediated cleavage of Desmoglein 2, Bos taurus"
xref: Reactome:REACT_98483 "Caspase-mediated cleavage of Etk, Rattus norvegicus"
xref: Reactome:REACT_98534 "Caspase-mediated cleavage of Lamin A, Rattus norvegicus"
xref: Reactome:REACT_98703 "Caspase-mediated cleavage of alpha adducin, Danio rerio"
xref: Reactome:REACT_98831 "Caspase mediated cleavage of C-IAP1, Gallus gallus"
xref: Reactome:REACT_98986 "Caspase-mediated cleavage of gelsolin, Gallus gallus"
xref: Reactome:REACT_99229 "Caspase-mediated cleavage of PKC theta, Danio rerio"
xref: Reactome:REACT_99392 "Caspase-mediated cleavage of Etk, Sus scrofa"
xref: Reactome:REACT_99637 "Activation of caspase-3, Mus musculus"
xref: Reactome:REACT_99764 "Caspase-mediated cleavage of Desmoglein 1, Bos taurus"
is_a: GO:0004175 ! endopeptidase activity
is_a: GO:0008234 ! cysteine-type peptidase activity

[Term]
id: GO:0004198
name: calcium-dependent cysteine-type endopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium." [GOC:mah]
subset: gosubset_prok
synonym: "calpain activity" NARROW []
is_a: GO:0004197 ! cysteine-type endopeptidase activity

[Term]
id: GO:0004200
name: obsolete signaling (initiator) caspase activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it includes biological process information.
synonym: "signaling (initiator) caspase activity" EXACT []
synonym: "signalling (initiator) caspase activity" EXACT []
is_obsolete: true
replaced_by: GO:0004197
consider: GO:0006915

[Term]
id: GO:0004201
name: obsolete caspase-1 activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of interleukin 1-beta by specific cleavage of Asp116-Ala117 and Asp27-Gly28 bonds in precursor. Enzymes with this function can also hydrolyze the terminal bond in the small-molecule substrate, Ac-Tyr-Val-Ala-Asp-NHMec." [EC:3.4.22.36]
comment: This term was made obsolete because it represents a gene product.
synonym: "caspase-1 activity" EXACT []
synonym: "ICE" BROAD []
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0004202
name: obsolete caspase-2 activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "caspase-2 activity" EXACT []
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0004203
name: obsolete caspase-4 activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "caspase-4 activity" EXACT []
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0004204
name: obsolete caspase-5 activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "caspase-5 activity" EXACT []
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0004205
name: obsolete caspase-8 activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "caspase-8 activity" EXACT []
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0004206
name: obsolete caspase-10 activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "caspase-10 activity" EXACT []
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0004207
name: obsolete effector caspase activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it includes biological process information.
synonym: "effector caspase activity" EXACT []
is_obsolete: true
replaced_by: GO:0004197
consider: GO:0006915

[Term]
id: GO:0004208
name: obsolete caspase-3 activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage at the terminal bond of the motif: Asp-Xaa-Xaa-Asp-Xaa. Enzymes with this function are members of the peptidase family C14 and they appear to function in the inactivation of proteins involved in cellular repair and homeostasis during the effector stage of apoptosis." [ISBN:0120793709]
comment: This term was made obsolete because it represents a gene product.
synonym: "caspase-3 activity" EXACT []
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0004209
name: obsolete caspase-6 activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "caspase-6 activity" EXACT []
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0004210
name: obsolete caspase-7 activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "caspase-7 activity" EXACT []
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0004211
name: obsolete caspase-9 activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "caspase-9 activity" EXACT []
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0004212
name: obsolete lysosomal cysteine-type endopeptidase
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it contains both component and function information.
synonym: "lysosomal cysteine-type endopeptidase" EXACT []
is_obsolete: true
consider: GO:0004197
consider: GO:0005764

[Term]
id: GO:0004213
name: obsolete cathepsin B activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds with a broad specificity. Preferentially cleaves the terminal bond of -Arg-Arg-Xaa motifs in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides." [EC:3.4.22.1]
comment: This term was made obsolete because it represents a gene product.
synonym: "cathepsin B activity" EXACT []
synonym: "cathepsin B1 activity" EXACT [EC:3.4.22.1]
synonym: "cathepsin II" RELATED [EC:3.4.22.1]
xref: EC:3.4.22.1
xref: MetaCyc:3.4.22.1-RXN
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0004214
name: obsolete dipeptidyl-peptidase I activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of an N-terminal dipeptide, Xaa-Xbb from Xaa-Xbb-Xcc, except when Xaa is Arg or Lys, or Xbb or Xcc is Pro." [EC:3.4.14.1]
comment: This term was made obsolete because it represents a gene product.
synonym: "cathepsin C activity" EXACT [EC:3.4.14.1]
synonym: "cathepsin J activity" EXACT [EC:3.4.14.1]
synonym: "DAP I" RELATED [EC:3.4.14.1]
synonym: "dipeptide arylamidase I" RELATED [EC:3.4.14.1]
synonym: "dipeptidyl aminopeptidase I activity" EXACT [EC:3.4.14.1]
synonym: "dipeptidyl transferase activity" EXACT [EC:3.4.14.1]
synonym: "dipeptidyl-peptidase I activity" EXACT []
xref: EC:3.4.14.1
xref: MetaCyc:3.4.14.1-RXN
is_obsolete: true
consider: GO:0008234
consider: GO:0008239

[Term]
id: GO:0004215
name: obsolete cathepsin H activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds, acting as an aminopeptidase (notably, cleaving Arg-Xaa bonds) as well as an endopeptidase." [EC:3.4.22.16]
comment: This term was made obsolete because it represents a gene product.
synonym: "aleurain activity" EXACT [EC:3.4.22.16]
synonym: "benzoylarginine-naphthylamide (BANA) hydrolase activity" EXACT [EC:3.4.22.16]
synonym: "cathepsin B3 activity" EXACT [EC:3.4.22.16]
synonym: "cathepsin Ba" RELATED [EC:3.4.22.16]
synonym: "cathepsin BA activity" EXACT [EC:3.4.22.16]
synonym: "cathepsin H activity" EXACT []
synonym: "N-benzoylarginine-beta-naphthylamide hydrolase activity" EXACT [EC:3.4.22.16]
xref: EC:3.4.22.16
xref: MetaCyc:3.4.22.16-RXN
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0004216
name: obsolete cathepsin K activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Has a broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg." [EC:3.4.22.38]
comment: This term was made obsolete because it represents a gene product.
synonym: "cathepsin K activity" EXACT []
synonym: "cathepsin O activity" EXACT [EC:3.4.22.38]
synonym: "cathepsin O2 activity" EXACT [EC:3.4.22.38]
synonym: "cathepsin X activity" EXACT [EC:3.4.22.38]
xref: EC:3.4.22.38
xref: MetaCyc:3.4.22.38-RXN
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0004217
name: obsolete cathepsin L activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity towards protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity." [EC:3.4.22.15]
comment: This term was made obsolete because it represents a gene product.
synonym: "Aldrichina grahami cysteine proteinase" NARROW [EC:3.4.22.15]
synonym: "cathepsin L activity" EXACT []
xref: EC:3.4.22.15
xref: MetaCyc:3.4.22.15-RXN
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0004218
name: obsolete cathepsin S activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Similar to cathepsin L, but with much less activity on the terminal bond of Z-Phe-Arg-NHMec, and more activity on the terminal bond of Z-Val-Val-Arg-Xaa compounds." [EC:3.4.22.27]
comment: This term was made obsolete because it represents a gene product.
synonym: "cathepsin S activity" EXACT []
xref: EC:3.4.22.27
xref: MetaCyc:3.4.22.27-RXN
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0004219
name: obsolete pyroglutamyl-peptidase I activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: pyroglutamyl-peptide + H2O = pyroglutamate + peptide." [EC:3.4.19.3]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "5-oxoprolyl-peptidase activity" EXACT [EC:3.4.19.3]
synonym: "L-pyroglutamyl peptide hydrolase activity" EXACT [EC:3.4.19.3]
synonym: "L-pyrrolidonecarboxylate peptidase activity" EXACT [EC:3.4.19.3]
synonym: "PYRase activity" EXACT [EC:3.4.19.3]
synonym: "pyroglutamate aminopeptidase activity" EXACT [EC:3.4.19.3]
synonym: "pyroglutamidase activity" EXACT [EC:3.4.19.3]
synonym: "pyroglutamyl aminopeptidase activity" EXACT [EC:3.4.19.3]
synonym: "pyroglutamyl-peptidase I activity" EXACT []
synonym: "pyrrolidone carboxyl peptidase activity" EXACT [EC:3.4.19.3]
synonym: "pyrrolidone-carboxyl peptidase activity" EXACT [EC:3.4.19.3]
synonym: "pyrrolidone-carboxylate peptidase activity" EXACT [EC:3.4.19.3]
synonym: "pyrrolidonecarboxylyl peptidase activity" EXACT [EC:3.4.19.3]
synonym: "pyrrolidonyl peptidase activity" EXACT [EC:3.4.19.3]
xref: EC:3.4.19.3
xref: MetaCyc:PYROGLUTAMYL-PEPTIDASE-I-RXN
is_obsolete: true
consider: GO:0008234
consider: GO:0016920

[Term]
id: GO:0004221
name: obsolete ubiquitin thiolesterase activity
namespace: molecular_function
alt_id: GO:0008577
def: "OBSOLETE. Catalysis of the reaction: ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol." [EC:3.1.2.15, GOC:jh2]
comment: This term was made obsolete because this molecular function does not exist.
synonym: "ubiquitin C-terminal hydrolase activity" RELATED []
synonym: "ubiquitin carboxy-terminal esterase activity" EXACT [EC:3.1.2.15]
synonym: "ubiquitin carboxy-terminal hydrolase activity" RELATED [EC:3.1.2.15]
synonym: "ubiquitin thioesterase activity" EXACT [EC:3.1.2.15]
synonym: "ubiquitin thiolesterase activity" EXACT []
synonym: "ubiquitin-C-terminal-thioester hydrolase activity" EXACT [EC:3.1.2.15]
synonym: "ubiquitinyl hydrolase 1 activity" NARROW []
xref: EC:3.1.2.15
xref: KEGG:R02418
xref: MetaCyc:UBIQUITIN-THIOLESTERASE-RXN
is_obsolete: true
consider: GO:0004843
consider: GO:0036459

[Term]
id: GO:0004222
name: metalloendopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
subset: gosubset_prok
synonym: "metalloendoprotease activity" NARROW [GOC:mah]
synonym: "metalloendoproteinase activity" NARROW [GOC:mah]
xref: EC:3.4.24
xref: Reactome:REACT_100500 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Matrix Metalloproteinase, Mus musculus"
xref: Reactome:REACT_102187 "Proteolysis of the IGF:IGFBP-4 Complex by PAPP-A, Bos taurus"
xref: Reactome:REACT_102738 "Proteolysis of the IGF:IGFBP-4 Complex by PAPP-A, Rattus norvegicus"
xref: Reactome:REACT_104692 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Matrix Metalloproteinase, Gallus gallus"
xref: Reactome:REACT_104704 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Matrix Metalloproteinase, Canis familiaris"
xref: Reactome:REACT_105137 "Proteolysis of the IGF:IGFBP-4 Complex by PAPP-A, Taeniopygia guttata"
xref: Reactome:REACT_105311 "Pro-EGF is cleaved to form mature EGF, Rattus norvegicus"
xref: Reactome:REACT_109473 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Matrix Metalloproteinase, Rattus norvegicus"
xref: Reactome:REACT_11089 "BoNT Light Chain Type E cleaves SNAP-25, Homo sapiens"
xref: Reactome:REACT_111084 "ADAM17 cleavage of Ghr, Mus musculus"
xref: Reactome:REACT_111197 "Metalloprotease cleavage of GHR, Homo sapiens"
xref: Reactome:REACT_11130 "BoNT Light Chain Type C1 cleaves SNAP-25, Homo sapiens"
xref: Reactome:REACT_11146 "BoNT Light Chain Type A cleaves SNAP-25, Homo sapiens"
xref: Reactome:REACT_11158 "BoNT Light Chain Type F cleaves VAMP, Homo sapiens"
xref: Reactome:REACT_11165 "BoNT Light Chain Type B cleaves VAMP-2, Homo sapiens"
xref: Reactome:REACT_11179 "BoNT Light Chain Type D cleaves VAMP, Homo sapiens"
xref: Reactome:REACT_11195 "BoNT Light Chain Type C1 cleaves Syntaxin, Homo sapiens"
xref: Reactome:REACT_115618 "Cleavage of P-ERBB4jmA isoforms by ADAM17, Homo sapiens"
xref: Reactome:REACT_115992 "Cleavage of P-ERBB4jmA isoforms by Adam17, Homo sapiens"
xref: Reactome:REACT_13407 "Conversion of pro-apoA-I to apoA-I, Homo sapiens"
xref: Reactome:REACT_15304 "Proteolysis of the IGF:IGFBP-5:ALS Complex by PAPP-A2, Homo sapiens"
xref: Reactome:REACT_15447 "Proteolysis of the IGF:IGFBP-4 Complex by PAPP-A, Homo sapiens"
xref: Reactome:REACT_15475 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Matrix Metalloproteinase, Homo sapiens"
xref: Reactome:REACT_28155 "Pro-EGF is cleaved to form mature EGF, Taeniopygia guttata"
xref: Reactome:REACT_28465 "Pro-EGF is cleaved to form mature EGF, Xenopus tropicalis"
xref: Reactome:REACT_30819 "Proteolysis of the IGF:IGFBP-5:ALS Complex by PAPP-A2, Taeniopygia guttata"
xref: Reactome:REACT_30876 "Proteolysis of the IGF:IGFBP-5:ALS Complex by PAPP-A2, Bos taurus"
xref: Reactome:REACT_31204 "Proteolysis of the IGF:IGFBP-4 Complex by PAPP-A, Mus musculus"
xref: Reactome:REACT_31767 "Conversion of pro-apoA-I to apoA-I, Danio rerio"
xref: Reactome:REACT_32065 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Matrix Metalloproteinase, Bos taurus"
xref: Reactome:REACT_33032 "Proteolysis of the IGF:IGFBP-5:ALS Complex by PAPP-A2, Canis familiaris"
xref: Reactome:REACT_33649 "Proteolysis of the IGF:IGFBP-5:ALS Complex by PAPP-A2, Gallus gallus"
xref: Reactome:REACT_34637 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Matrix Metalloproteinase, Danio rerio"
xref: Reactome:REACT_46117 "Pro-EGF is cleaved to form mature EGF, Gallus gallus"
xref: Reactome:REACT_48941 "Conversion of pro-apoA-I to apoA-I, Bos taurus"
xref: Reactome:REACT_79685 "Proteolysis of the IGF:IGFBP-4 Complex by PAPP-A, Canis familiaris"
xref: Reactome:REACT_81221 "Pro-EGF is cleaved to form mature EGF, Canis familiaris"
xref: Reactome:REACT_83047 "Proteolysis of the IGF:IGFBP-4 Complex by PAPP-A, Xenopus tropicalis"
xref: Reactome:REACT_84535 "Proteolysis of the IGF:IGFBP-5:ALS Complex by PAPP-A2, Danio rerio"
xref: Reactome:REACT_85568 "Pro-EGF is cleaved to form mature EGF, Danio rerio"
xref: Reactome:REACT_85944 "Conversion of pro-apoA-I to apoA-I, Xenopus tropicalis"
xref: Reactome:REACT_87955 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Matrix Metalloproteinase, Sus scrofa"
xref: Reactome:REACT_89938 "Proteolysis of the IGF:IGFBP-5:ALS Complex by PAPP-A2, Xenopus tropicalis"
xref: Reactome:REACT_9030 "Mouse pro-EGF is cleaved by ADAM sheddases, Mus musculus"
xref: Reactome:REACT_90847 "Proteolysis of the IGF:IGFBP-4 Complex by PAPP-A, Sus scrofa"
xref: Reactome:REACT_91391 "Proteolysis of the IGF:IGFBP-5:ALS Complex by PAPP-A2, Mus musculus"
xref: Reactome:REACT_93439 "Conversion of pro-apoA-I to apoA-I, Mus musculus"
xref: Reactome:REACT_9423 "Pro-EGF is cleaved to form mature EGF, Homo sapiens"
xref: Reactome:REACT_96741 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Matrix Metalloproteinase, Taeniopygia guttata"
xref: Reactome:REACT_97379 "Conversion of pro-apoA-I to apoA-I, Sus scrofa"
xref: Reactome:REACT_97836 "Conversion of pro-apoA-I to apoA-I, Canis familiaris"
xref: Reactome:REACT_98257 "Proteolysis of the IGF:IGFBP-5:ALS Complex by PAPP-A2, Rattus norvegicus"
xref: Reactome:REACT_98581 "Proteolysis of the IGF:IGFBP-5:ALS Complex by PAPP-A2, Sus scrofa"
is_a: GO:0004175 ! endopeptidase activity
is_a: GO:0008237 ! metallopeptidase activity

[Term]
id: GO:0004226
name: obsolete Gly-X carboxypeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: peptidyl-Gly-Xaa + H2O = peptidyl-Gly + Xaa." [EC:3.4.17.4]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "carboxypeptidase a" RELATED [EC:3.4.17.4]
synonym: "carboxypeptidase S activity" EXACT [EC:3.4.17.4]
synonym: "Gly-X carboxypeptidase activity" EXACT []
synonym: "Gly-Xaa carboxypeptidase activity" EXACT [EC:3.4.17.4]
synonym: "glycine carboxypeptidase activity" EXACT [EC:3.4.17.4]
synonym: "peptidase alpha" RELATED [EC:3.4.17.4]
synonym: "yeast carboxypeptidase activity" EXACT [EC:3.4.17.4]
xref: EC:3.4.17.4
xref: MetaCyc:GLY-X-CARBOXYPEPTIDASE-RXN
is_obsolete: true
replaced_by: GO:0004181

[Term]
id: GO:0004228
name: obsolete gelatinase A activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-Ile-Ala-Gly-Gln at the Gly-Ile bond." [EC:3.4.24.24]
comment: This term was made obsolete because it represents a gene product.
synonym: "3/4 collagenase activity" EXACT [EC:3.4.24.24]
synonym: "72 kDa gelatinase type A" RELATED [EC:3.4.24.24]
synonym: "72-kDa gelatinase activity" NARROW [EC:3.4.24.24]
synonym: "collagenase IV" RELATED [EC:3.4.24.24]
synonym: "collagenase type IV" RELATED [EC:3.4.24.24]
synonym: "gelatinase A activity" EXACT []
synonym: "matrix metalloproteinase 2 activity" EXACT [EC:3.4.24.24]
synonym: "matrix metalloproteinase 5" RELATED [EC:3.4.24.24]
synonym: "MMP 2" RELATED [EC:3.4.24.24]
synonym: "MMP-2" EXACT []
synonym: "type IV collagen metalloproteinase" BROAD [EC:3.4.24.24]
synonym: "type IV collagenase activity" EXACT [EC:3.4.24.24]
synonym: "type IV collagenase/gelatinase activity" EXACT [EC:3.4.24.24]
xref: EC:3.4.24.24
xref: MetaCyc:3.4.24.24-RXN
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0004229
name: obsolete gelatinase B activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of gelatin types I and V and collagen types IV and V." [EC:3.4.24.35]
comment: This term was made obsolete because it represents a gene product.
synonym: "92-kDa gelatinase activity" NARROW [EC:3.4.24.35]
synonym: "92-kDa type IV collagenase activity" NARROW [EC:3.4.24.35]
synonym: "95 kDa type IV collagenase/gelatinase activity" EXACT [EC:3.4.24.35]
synonym: "collagenase IV" RELATED [EC:3.4.24.35]
synonym: "collagenase type IV" RELATED [EC:3.4.24.35]
synonym: "gelatinase B activity" EXACT []
synonym: "gelatinase MMP 9" RELATED [EC:3.4.24.35]
synonym: "macrophage gelatinase activity" NARROW [EC:3.4.24.35]
synonym: "matrix metalloproteinase 9 activity" EXACT [EC:3.4.24.35]
synonym: "MMP 9" RELATED [EC:3.4.24.35]
synonym: "MMP-9" EXACT []
synonym: "type IV collagen metalloproteinase" BROAD [EC:3.4.24.35]
synonym: "type V collagenase activity" EXACT [EC:3.4.24.35]
xref: EC:3.4.24.35
xref: MetaCyc:3.4.24.35-RXN
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0004230
name: obsolete glutamyl aminopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of a N-terminal glutamate (and to a lesser extent aspartate) from a peptide." [EC:3.4.11.7]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "aminopeptidase A" RELATED [EC:3.4.11.7]
synonym: "angiotensinase A" RELATED [EC:3.4.11.7]
synonym: "angiotensinase A2" RELATED [EC:3.4.11.7]
synonym: "antigen BP-1/6C3 of mouse B lymphocytes" RELATED [EC:3.4.11.7]
synonym: "aspartate aminopeptidase activity" EXACT [EC:3.4.11.7]
synonym: "Ca2+-activated glutamate aminopeptidase activity" EXACT [EC:3.4.11.7]
synonym: "glutamyl aminopeptidase activity" EXACT []
synonym: "glutamyl peptidase activity" EXACT [EC:3.4.11.7]
synonym: "L-aspartate aminopeptidase activity" EXACT [EC:3.4.11.7]
synonym: "membrane aminopeptidase II" RELATED [EC:3.4.11.7]
xref: EC:3.4.11.7
xref: MetaCyc:3.4.11.7-RXN
is_obsolete: true
consider: GO:0004177
consider: GO:0008235

[Term]
id: GO:0004231
name: obsolete insulysin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the degradation of insulin, glucagon and other polypeptides. No action on proteins." [EC:3.4.24.56]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "IDE" RELATED [EC:3.4.24.56]
synonym: "insulin protease activity" EXACT [EC:3.4.24.56]
synonym: "insulin proteinase activity" EXACT [EC:3.4.24.56]
synonym: "insulin-degrading enzyme activity" EXACT [EC:3.4.24.56]
synonym: "insulin-degrading neutral proteinase activity" EXACT [EC:3.4.24.56]
synonym: "insulin-glucagon protease activity" EXACT [EC:3.4.24.56]
synonym: "insulin-specific protease activity" EXACT [EC:3.4.24.56]
synonym: "insulinase activity" EXACT [EC:3.4.24.56]
synonym: "insulysin activity" EXACT []
synonym: "metalloinsulinase activity" EXACT [EC:3.4.24.56]
xref: EC:3.4.24.56
xref: MetaCyc:3.4.24.56-RXN
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0004232
name: obsolete interstitial collagenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the preferential cleavage of one bond in native collagen. Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at Gly775-Ile776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue." [EC:3.4.24.7]
comment: This term was made obsolete because it represents a gene product.
synonym: "interstitial collagenase activity" EXACT []
synonym: "matrix metalloproteinase 1" EXACT []
synonym: "MMP-1" EXACT []
synonym: "vertebrate collagenase activity" EXACT [EC:3.4.24.7]
xref: EC:3.4.24.7
xref: MetaCyc:3.4.24.7-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004234
name: obsolete macrophage elastase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at Ala14-Leu15 and Tyr16-Leu17 in the B chain of insulin." [EC:3.4.24.65]
comment: This term was made obsolete because it represents a gene product.
synonym: "human macrophage metalloelastase (HME)" EXACT [EC:3.4.24.65]
synonym: "macrophage elastase activity" EXACT []
synonym: "matrix metalloproteinase 12 activity" EXACT [EC:3.4.24.65]
synonym: "metalloelastase activity" EXACT [EC:3.4.24.65]
synonym: "metalloesterase activity" EXACT []
synonym: "MMP-12" EXACT []
xref: EC:3.4.24.65
xref: MetaCyc:3.4.24.65-RXN
is_obsolete: true
consider: GO:0004175
consider: GO:0004222

[Term]
id: GO:0004235
name: obsolete matrilysin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of Ala14-Leu15 and Tyr16-Leu17 in B chain of insulin. No action on collagen types I, II, IV and V. Cleaves gelatin chain alpha-2(I) > alpha-1(I)." [EC:3.4.24.23]
comment: This term was made obsolete because it represents a gene product.
synonym: "matrilysin activity" EXACT []
synonym: "matrin activity" EXACT [EC:3.4.24.23]
synonym: "matrix metalloproteinase 7 activity" EXACT [EC:3.4.24.23]
synonym: "matrix metalloproteinase pump 1" RELATED [EC:3.4.24.23]
synonym: "metalloproteinase pump-1" RELATED [EC:3.4.24.23]
synonym: "MMP" RELATED [EC:3.4.24.23]
synonym: "MMP 7" RELATED [EC:3.4.24.23]
synonym: "MMP-7" EXACT []
synonym: "PUMP" RELATED [EC:3.4.24.23]
synonym: "PUMP-1 activity" NARROW [EC:3.4.24.23]
synonym: "PUMP-1 proteinase activity" EXACT [EC:3.4.24.23]
synonym: "putative (or punctuated) metalloproteinase-1 activity" NARROW [EC:3.4.24.23]
synonym: "putative metalloproteinase activity" EXACT [EC:3.4.24.23]
synonym: "uterine metalloendopeptidase activity" NARROW [EC:3.4.24.23]
xref: EC:3.4.24.23
xref: MetaCyc:3.4.24.23-RXN
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0004237
name: obsolete membrane dipeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of dipeptides." [EC:3.4.13.19]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "aminodipeptidase activity" EXACT [EC:3.4.13.19]
synonym: "dehydropeptidase I (DPH I)" RELATED [EC:3.4.13.19]
synonym: "dehydropeptidase I activity" EXACT [EC:3.4.13.19]
synonym: "dipeptide hydrolase" BROAD [EC:3.4.13.19]
synonym: "dipeptidyl hydrolase activity" EXACT [EC:3.4.13.19]
synonym: "DPH I activity" NARROW [EC:3.4.13.19]
synonym: "glycosyl-phosphatidylinositol-anchored renal dipeptidase activity" EXACT [EC:3.4.13.19]
synonym: "MDP" RELATED [EC:3.4.13.19]
synonym: "membrane dipeptidase activity" EXACT []
synonym: "microsomal dipeptidase activity" NARROW [EC:3.4.13.19]
synonym: "nonspecific dipeptidase activity" EXACT [EC:3.4.13.19]
synonym: "renal dipeptidase activity" NARROW [EC:3.4.13.19]
xref: EC:3.4.13.19
xref: MetaCyc:3.4.13.19-RXN
is_obsolete: true
consider: GO:0008235
consider: GO:0016805

[Term]
id: GO:0004238
name: obsolete meprin A activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues." [EC:3.4.24.18]
comment: This term was made obsolete because it represents a gene product.
synonym: "endopeptidase-2 activity" BROAD [EC:3.4.24.18]
synonym: "meprin" RELATED [EC:3.4.24.18]
synonym: "meprin A activity" EXACT []
synonym: "meprin-a" RELATED [EC:3.4.24.18]
synonym: "N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase activity" EXACT [EC:3.4.24.18]
synonym: "PABA-peptide hydrolase activity" EXACT [EC:3.4.24.18]
synonym: "PPH" RELATED [EC:3.4.24.18]
xref: EC:3.4.24.18
xref: MetaCyc:3.4.24.18-RXN
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0004239
name: obsolete methionyl aminopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of N-terminal amino acids, preferentially methionine, from peptides and arylamides." [EC:3.4.11.18]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "L-methionine aminopeptidase activity" EXACT [EC:3.4.11.18]
synonym: "MAP" RELATED [EC:3.4.11.18]
synonym: "methionine aminopeptidase activity" EXACT [EC:3.4.11.18]
synonym: "methionyl aminopeptidase activity" EXACT []
synonym: "peptidase M activity" EXACT [EC:3.4.11.18]
xref: EC:3.4.11.18
xref: MetaCyc:3.4.11.18-RXN
is_obsolete: true
consider: GO:0004177
consider: GO:0008235
consider: GO:0070084

[Term]
id: GO:0004240
name: obsolete mitochondrial processing peptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2." [EC:3.4.24.64]
comment: This term was made obsolete because it represents a gene product.
synonym: "alpha-mitochondrial processing peptidase" NARROW []
synonym: "beta-mitochondrial processing peptidase" NARROW []
synonym: "matrix peptidase" RELATED [EC:3.4.24.64]
synonym: "matrix processing peptidase" RELATED [EC:3.4.24.64]
synonym: "matrix processing proteinase" RELATED [EC:3.4.24.64]
synonym: "mitochondrial processing peptidase activity" EXACT []
synonym: "mitochondrial protein precursor-processing proteinase activity" EXACT [EC:3.4.24.64]
synonym: "MPP" EXACT []
synonym: "processing enhancing peptidase (for one of two subunits)" RELATED [EC:3.4.24.64]
synonym: "processing enhancing peptidase activity" NARROW [EC:3.4.24.64]
xref: EC:3.4.24.64
xref: MetaCyc:3.4.24.64-RXN
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0004241
name: obsolete alpha-mitochondrial processing peptidase
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "alpha-mitochondrial processing peptidase" EXACT []
synonym: "alpha-MPP" EXACT []
is_obsolete: true
consider: GO:0004222
consider: GO:0005739

[Term]
id: GO:0004242
name: obsolete beta-mitochondrial processing peptidase
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "beta-mitochondrial processing peptidase" EXACT []
synonym: "beta-MPP" EXACT []
is_obsolete: true
consider: GO:0004222
consider: GO:0005739

[Term]
id: GO:0004243
name: obsolete mitochondrial intermediate peptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of an N-terminal octapeptide as second stage of processing of some proteins imported in the mitochondrion." [EC:3.4.24.59]
comment: This term was made obsolete because it represents a gene product.
synonym: "MIP" BROAD []
synonym: "mitochondrial intermediate peptidase activity" EXACT []
synonym: "mitochondrial intermediate precursor-processing proteinase activity" EXACT [EC:3.4.24.59]
xref: EC:3.4.24.59
xref: MetaCyc:3.4.24.59-RXN
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0004244
name: obsolete mitochondrial inner membrane peptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the maturation of mitochondrial precursor proteins delivered to the intermembrane space." [PMID:12191769]
comment: This term was made obsolete because it represents a gene product.
synonym: "IMP" BROAD []
synonym: "mitochondrial inner membrane peptidase activity" EXACT []
xref: EC:3.4.99.-
is_obsolete: true
replaced_by: GO:0004175

[Term]
id: GO:0004245
name: obsolete neprilysin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the preferential cleavage at the amino group of hydrophobic residues in insulin, casein, hemoglobin, and a number of other proteins and polypeptides." [EC:3.4.24.11]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "acute lymphoblastic leukemia antigen" RELATED [EC:3.4.24.11]
synonym: "CALLA" RELATED [EC:3.4.24.11]
synonym: "CALLA (common acute lymphoblastic leukemia-associated) antigens" RELATED [EC:3.4.24.11]
synonym: "CALLA antigen" RELATED [EC:3.4.24.11]
synonym: "CALLA glycoprotein" RELATED [EC:3.4.24.11]
synonym: "CALLA glycoproteins" RELATED [EC:3.4.24.11]
synonym: "CD10" RELATED [EC:3.4.24.11]
synonym: "common acute lymphoblastic leukemia antigen" RELATED [EC:3.4.24.11]
synonym: "common acute lymphoblastic leukemia-associated antigens" RELATED [EC:3.4.24.11]
synonym: "endopeptidase 24.11" RELATED [EC:3.4.24.11]
synonym: "endopeptidase-2 activity" BROAD [EC:3.4.24.11]
synonym: "enkephalinase activity" EXACT [EC:3.4.24.11]
synonym: "kidney-brush-border neutral endopeptidase" NARROW [EC:3.4.24.11]
synonym: "kidney-brush-border neutral peptidase" NARROW [EC:3.4.24.11]
synonym: "kidney-brush-border neutral proteinase activity" NARROW [EC:3.4.24.11]
synonym: "membrane metalloendopeptidase activity" NARROW [EC:3.4.24.11]
synonym: "neprilysin activity" EXACT []
synonym: "neutral endopeptidase 24.11" RELATED [EC:3.4.24.11]
synonym: "neutral endopeptidase activity" EXACT [EC:3.4.24.11]
synonym: "neutral metallendopeptidase activity" EXACT [EC:3.4.24.11]
xref: EC:3.4.24.11
xref: MetaCyc:3.4.24.11-RXN
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0004246
name: obsolete peptidyl-dipeptidase A activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of a C-terminal dipeptide, Xaa-Xbb from oligopeptide-Xaa-Xbb, when Xaa is not Pro, and Xbb is neither Asp nor Glu. Converts angiotensin I to angiotensin II." [EC:3.4.15.1]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "ACE activity" BROAD []
synonym: "angiotensin converting enzyme" RELATED [EC:3.4.15.1]
synonym: "angiotensin I-converting enzyme activity" EXACT [EC:3.4.15.1]
synonym: "carboxycathepsin activity" EXACT [EC:3.4.15.1]
synonym: "DCP" RELATED [EC:3.4.15.1]
synonym: "dipeptide hydrolase" BROAD [EC:3.4.15.1]
synonym: "dipeptidyl carboxypeptidase I activity" EXACT [EC:3.4.15.1]
synonym: "endothelial cell peptidyl dipeptidase activity" EXACT [EC:3.4.15.1]
synonym: "kininase II activity" EXACT [EC:3.4.15.1]
synonym: "PDH" RELATED [EC:3.4.15.1]
synonym: "peptidase P activity" EXACT [EC:3.4.15.1]
synonym: "peptidyl dipeptidase A" RELATED [EC:3.4.15.1]
synonym: "peptidyl dipeptidase I activity" EXACT [EC:3.4.15.1]
synonym: "peptidyl dipeptidase-4" RELATED [EC:3.4.15.1]
synonym: "peptidyl dipeptide hydrolase activity" EXACT [EC:3.4.15.1]
synonym: "peptidyl-dipeptidase A activity" EXACT []
synonym: "peptidyl-dipeptide hydrolase activity" EXACT [EC:3.4.15.1]
synonym: "peptidyldipeptide hydrolase activity" EXACT [EC:3.4.15.1]
xref: EC:3.4.15.1
xref: MetaCyc:3.4.15.1-RXN
is_obsolete: true
consider: GO:0008237
consider: GO:0008241

[Term]
id: GO:0004247
name: obsolete saccharolysin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of Pro-Phe and Ala-Ala bonds." [EC:3.4.24.37]
comment: This term was made obsolete because it represents a gene product.
synonym: "oligopeptidase yscD activity" NARROW [EC:3.4.24.37]
synonym: "proteinase yscD activity" NARROW [EC:3.4.24.37]
synonym: "saccharolysin activity" EXACT []
synonym: "saccharomyces cerevisiae proteinase yscD" RELATED [EC:3.4.24.37]
synonym: "yeast cysteine proteinase D activity" NARROW [EC:3.4.24.37]
xref: EC:3.4.24.37
xref: MetaCyc:3.4.24.37-RXN
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0004248
name: obsolete stromelysin 1 activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the preferential cleavage where P1', P2' and P3' are hydrophobic residues." [EC:3.4.24.17]
comment: This term was made obsolete because it represents a gene product.
synonym: "collagen-activating protein" RELATED [EC:3.4.24.17]
synonym: "collagenase activating protein" RELATED [EC:3.4.24.17]
synonym: "matrix metalloproteinase 3 activity" EXACT [EC:3.4.24.17]
synonym: "MMP-3" EXACT []
synonym: "neutral proteoglycanase activity" EXACT [EC:3.4.24.17]
synonym: "procollagenase activator" RELATED [EC:3.4.24.17]
synonym: "proteoglycanase activity" EXACT [EC:3.4.24.17]
synonym: "stromelysin" RELATED [EC:3.4.24.17]
synonym: "stromelysin 1 activity" EXACT []
synonym: "transin activity" EXACT [EC:3.4.24.17]
xref: EC:3.4.24.17
xref: MetaCyc:3.4.24.17-RXN
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0004249
name: obsolete stromelysin 3 activity
namespace: molecular_function
def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "matrix metalloproteinase 11" EXACT []
synonym: "MMP-11" EXACT []
synonym: "stromelysin 3 activity" EXACT []
xref: EC:3.4.24.-
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0004250
name: obsolete aminopeptidase I activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of an N-terminal amino acid, preferably a neutral or hydrophobic one, from a polypeptide. Aminoacyl-arylamides are poor substrates." [EC:3.4.11.22]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "aminopeptidase I activity" EXACT []
synonym: "aminopeptidase III activity" EXACT [EC:3.4.11.22]
synonym: "aminopeptidase yscI activity" NARROW [EC:3.4.11.22]
synonym: "leucine aminopeptidase IV activity" EXACT [EC:3.4.11.22]
synonym: "vacuolar aminopeptidase I activity" NARROW [EC:3.4.11.22]
synonym: "yeast aminopeptidase I" RELATED [EC:3.4.11.22]
xref: EC:3.4.11.22
xref: MetaCyc:3.4.11.22-RXN
is_obsolete: true
consider: GO:0004177
consider: GO:0008235

[Term]
id: GO:0004251
name: obsolete X-Pro dipeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro." [EC:3.4.13.9]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "gamma-peptidase activity" EXACT [EC:3.4.13.9]
synonym: "imidodipeptidase activity" EXACT [EC:3.4.13.9]
synonym: "peptidase D" RELATED [EC:3.4.13.9]
synonym: "prolidase activity" EXACT [EC:3.4.13.9]
synonym: "proline dipeptidase activity" EXACT [EC:3.4.13.9]
synonym: "X-Pro dipeptidase activity" EXACT []
synonym: "Xaa-Pro dipeptidase activity" EXACT []
xref: EC:3.4.13.9
xref: MetaCyc:3.4.13.9-RXN
is_obsolete: true
consider: GO:0008235
consider: GO:0016805

[Term]
id: GO:0004252
name: serine-type endopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
subset: goslim_chembl
subset: gosubset_prok
synonym: "blood coagulation factor activity" RELATED []
synonym: "serine elastase activity" RELATED [GOC:krc]
xref: EC:3.4.21
xref: Reactome:REACT_100031 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain), Danio rerio"
xref: Reactome:REACT_100125 "Granzyme-B activates BID by cleavage, Mus musculus"
xref: Reactome:REACT_100194 "Thrombin-mediated activation of Proteinase-activated receptors, Taeniopygia guttata"
xref: Reactome:REACT_100271 "pro-factor IX -> factor IX + factor IX propeptide, Rattus norvegicus"
xref: Reactome:REACT_100321 "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst), Rattus norvegicus"
xref: Reactome:REACT_10058 "Part of pro-beta-NGF is processed to mature beta-NGF, Homo sapiens"
xref: Reactome:REACT_100669 "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides, Rattus norvegicus"
xref: Reactome:REACT_100764 "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst), Gallus gallus"
xref: Reactome:REACT_100842 "pro-factor VII -> factor VII + factor VII propeptide, Canis familiaris"
xref: Reactome:REACT_100919 "Formation of alternate C5 convertase, Mus musculus"
xref: Reactome:REACT_100938 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Thrombin, Canis familiaris"
xref: Reactome:REACT_101008 "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst), Rattus norvegicus"
xref: Reactome:REACT_101012 "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst), Danio rerio"
xref: Reactome:REACT_101033 "Processing of Proglucagon to Glucagon-like Peptide-1, Rattus norvegicus"
xref: Reactome:REACT_101265 "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides, Gallus gallus"
xref: Reactome:REACT_101293 "pro-factor IX -> factor IX + factor IX propeptide, Mus musculus"
xref: Reactome:REACT_101358 "Notch 1 precursor cleaved to form a heterodimer, Rattus norvegicus"
xref: Reactome:REACT_101408 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst), Bos taurus"
xref: Reactome:REACT_101486 "Granzyme-B activates BID by cleavage, Canis familiaris"
xref: Reactome:REACT_101710 "Proteolytic Cleavage of Glucagon-like Peptide-1 (GLP-1), Bos taurus"
xref: Reactome:REACT_102047 "Processing of preproGLP-1 to proGLP-1, Xenopus tropicalis"
xref: Reactome:REACT_102222 "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B, Danio rerio"
xref: Reactome:REACT_102226 "factor Va -> factor Vi, Taeniopygia guttata"
xref: Reactome:REACT_102247 "urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR, Sus scrofa"
xref: Reactome:REACT_102300 "pro-factor VII -> factor VII + factor VII propeptide, Gallus gallus"
xref: Reactome:REACT_102318 "Processing of preproGLP-1 to proGLP-1, Mus musculus"
xref: Reactome:REACT_102435 "Proteolytic Cleavage of Glucagon-like Peptide-1 (GLP-1), Canis familiaris"
xref: Reactome:REACT_102450 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin, Bos taurus"
xref: Reactome:REACT_102555 "Cleavage of ATF6-alpha by S1P, Drosophila melanogaster"
xref: Reactome:REACT_102564 "Notch 1 precursor cleaved to form a heterodimer, Mus musculus"
xref: Reactome:REACT_102660 "Factor D cleaves C3b-bound Factor B, Danio rerio"
xref: Reactome:REACT_102717 "factor Va -> factor Vi, Bos taurus"
xref: Reactome:REACT_102762 "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst), Mus musculus"
xref: Reactome:REACT_103193 "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin, Taeniopygia guttata"
xref: Reactome:REACT_103297 "Extracellular processing of novel PDGFs, Gallus gallus"
xref: Reactome:REACT_103317 "protein C -> activated protein C + protein C heavy chain activation peptide, Bos taurus"
xref: Reactome:REACT_103386 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst), Xenopus tropicalis"
xref: Reactome:REACT_103434 "Processing of Proinsulin to Insulin, Rattus norvegicus"
xref: Reactome:REACT_103529 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin, Canis familiaris"
xref: Reactome:REACT_103532 "Processing of classical PDGFs, Gallus gallus"
xref: Reactome:REACT_103534 "Latent TGF-beta1 is cleaved by furin, Xenopus tropicalis"
xref: Reactome:REACT_103821 "pro-factor X -> factor X + factor X propeptide, Gallus gallus"
xref: Reactome:REACT_104063 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Thrombin, Sus scrofa"
xref: Reactome:REACT_104096 "Processing of preproGLP-1 to proGLP-1, Canis familiaris"
xref: Reactome:REACT_104436 "pro-factor IX -> factor IX + factor IX propeptide, Gallus gallus"
xref: Reactome:REACT_104461 "Proteolytic Cleavage of Glucagon-like Peptide-1 (GLP-1), Danio rerio"
xref: Reactome:REACT_104513 "Conversion of C2 into C2a and C2b, Mus musculus"
xref: Reactome:REACT_104582 "Part of pro-beta-NGF is processed to mature beta-NGF, Sus scrofa"
xref: Reactome:REACT_104633 "factor Va -> factor Vi, Mus musculus"
xref: Reactome:REACT_104789 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin, Taeniopygia guttata"
xref: Reactome:REACT_104808 "Processing of Proinsulin to Insulin, Taeniopygia guttata"
xref: Reactome:REACT_104872 "Cleavage of ATF6-alpha by S1P, Gallus gallus"
xref: Reactome:REACT_104930 "pro-factor IX -> factor IX + factor IX propeptide, Sus scrofa"
xref: Reactome:REACT_105381 "Notch 1 precursor cleaved to form a heterodimer, Danio rerio"
xref: Reactome:REACT_105667 "Processing of Proglucagon to Glucagon-like Peptide-1, Canis familiaris"
xref: Reactome:REACT_105786 "Processing of Proglucagon to Glucagon-like Peptide-1, Taeniopygia guttata"
xref: Reactome:REACT_106150 "pro-GAS6 -> GAS6 + GAS6 propeptide, Sus scrofa"
xref: Reactome:REACT_106201 "Processing of proGIP to GIP, Rattus norvegicus"
xref: Reactome:REACT_106288 "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst), Rattus norvegicus"
xref: Reactome:REACT_106360 "pro-factor IX -> factor IX + factor IX propeptide, Danio rerio"
xref: Reactome:REACT_106442 "Cleavage of the Signal Peptide of Preproghrelin, Bos taurus"
xref: Reactome:REACT_1065 "pro-prothrombin -> prothrombin + prothrombin propeptide, Homo sapiens"
xref: Reactome:REACT_106545 "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B, Canis familiaris"
xref: Reactome:REACT_106587 "pro-prothrombin -> prothrombin + prothrombin propeptide, Mus musculus"
xref: Reactome:REACT_106621 "Notch 3 precursor cleaved to form a heterodimer, Canis familiaris"
xref: Reactome:REACT_106696 "C3(H2O):Factor Bb cleaves C3 to C3b and C3a, Canis familiaris"
xref: Reactome:REACT_106726 "pro-GAS6 -> GAS6 + GAS6 propeptide, Taeniopygia guttata"
xref: Reactome:REACT_106877 "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst), Danio rerio"
xref: Reactome:REACT_106997 "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin, Rattus norvegicus"
xref: Reactome:REACT_107059 "pro-factor IX -> factor IX + factor IX propeptide, Canis familiaris"
xref: Reactome:REACT_1071 "factor Va -> factor Vi, Homo sapiens"
xref: Reactome:REACT_107173 "pro-protein Z -> protein Z + protein Z propeptide, Rattus norvegicus"
xref: Reactome:REACT_107386 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst), Sus scrofa"
xref: Reactome:REACT_107456 "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst), Sus scrofa"
xref: Reactome:REACT_107494 "Processing of preproGLP-1 to proGLP-1, Sus scrofa"
xref: Reactome:REACT_107597 "Granzyme-B activates BID by cleavage, Sus scrofa"
xref: Reactome:REACT_107831 "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B, Gallus gallus"
xref: Reactome:REACT_107946 "pro-protein S -> protein S + protein S propeptide, Sus scrofa"
xref: Reactome:REACT_108231 "Activation of C1R, Sus scrofa"
xref: Reactome:REACT_108261 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst), Bos taurus"
xref: Reactome:REACT_108266 "Cleavage of ATF6-alpha by S1P, Canis familiaris"
xref: Reactome:REACT_108267 "Processing of proGIP to GIP, Canis familiaris"
xref: Reactome:REACT_108525 "pro-factor VII -> factor VII + factor VII propeptide, Danio rerio"
xref: Reactome:REACT_108824 "Extracellular processing of novel PDGFs, Canis familiaris"
xref: Reactome:REACT_108968 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Prostate-specific Antigen, Mus musculus"
xref: Reactome:REACT_109057 "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst), Danio rerio"
xref: Reactome:REACT_109058 "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides, Canis familiaris"
xref: Reactome:REACT_109495 "Notch 2 precursor cleaved to form a heterodimer, Drosophila melanogaster"
xref: Reactome:REACT_109499 "Processing of Proglucagon to Glucagon-like Peptide-1, Sus scrofa"
xref: Reactome:REACT_1097 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst), Homo sapiens"
xref: Reactome:REACT_109879 "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst), Canis familiaris"
xref: Reactome:REACT_109955 "Cleavage of ATF6-alpha by S1P, Taeniopygia guttata"
xref: Reactome:REACT_110020 "Thrombin-mediated activation of Proteinase-activated receptors, Mus musculus"
xref: Reactome:REACT_110040 "pro-factor IX -> factor IX + factor IX propeptide, Taeniopygia guttata"
xref: Reactome:REACT_110135 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst), Gallus gallus"
xref: Reactome:REACT_110160 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst), Taeniopygia guttata"
xref: Reactome:REACT_110219 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst), Mus musculus"
xref: Reactome:REACT_110269 "factor VII -> factor VIIa, Danio rerio"
xref: Reactome:REACT_110434 "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst), Mus musculus"
xref: Reactome:REACT_110438 "Part of pro-beta-NGF is processed to mature beta-NGF, Mus musculus"
xref: Reactome:REACT_110522 "Notch 4 precursor cleaved to form a heterodimer, Bos taurus"
xref: Reactome:REACT_110563 "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst), Danio rerio"
xref: Reactome:REACT_110705 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Thrombin, Taeniopygia guttata"
xref: Reactome:REACT_110746 "Proteolytic Cleavage of Glucagon-like Peptide-1 (GLP-1), Mus musculus"
xref: Reactome:REACT_110798 "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst), Bos taurus"
xref: Reactome:REACT_110898 "Extracellular processing of novel PDGFs, Mus musculus"
xref: Reactome:REACT_111180 "Cleavage of Nodal Proprotein, Mus musculus"
xref: Reactome:REACT_111228 "Cleavage of NODAL Proprotein, Homo sapiens"
xref: Reactome:REACT_1117 "pro-GAS6 -> GAS6 + GAS6 propeptide, Homo sapiens"
xref: Reactome:REACT_112053 "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst), Canis familiaris"
xref: Reactome:REACT_112058 "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst), Xenopus tropicalis"
xref: Reactome:REACT_112131 "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst), Gallus gallus"
xref: Reactome:REACT_11214 "The signal peptide is excised from pre-pro-NGF, Mus musculus"
xref: Reactome:REACT_112143 "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst), Bos taurus"
xref: Reactome:REACT_112184 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin, Xenopus tropicalis"
xref: Reactome:REACT_112194 "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst), Danio rerio"
xref: Reactome:REACT_112204 "factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer, Sus scrofa"
xref: Reactome:REACT_112253 "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides, Danio rerio"
xref: Reactome:REACT_112277 "Granzyme-B activates BID by cleavage, Xenopus tropicalis"
xref: Reactome:REACT_112440 "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst), Xenopus tropicalis"
xref: Reactome:REACT_112453 "Notch 3 precursor cleaved to form a heterodimer, Drosophila melanogaster"
xref: Reactome:REACT_112489 "factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer, Bos taurus"
xref: Reactome:REACT_112510 "factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer, Rattus norvegicus"
xref: Reactome:REACT_112675 "factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer, Xenopus tropicalis"
xref: Reactome:REACT_1127 "Notch 1 precursor cleaved to form a heterodimer, Homo sapiens"
xref: Reactome:REACT_112763 "Notch 4 precursor cleaved to form a heterodimer, Xenopus tropicalis"
xref: Reactome:REACT_112800 "Latent TGF-beta1 is cleaved by furin, Caenorhabditis elegans"
xref: Reactome:REACT_112843 "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst), Xenopus tropicalis"
xref: Reactome:REACT_113002 "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst), Rattus norvegicus"
xref: Reactome:REACT_113239 "factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer, Gallus gallus"
xref: Reactome:REACT_113539 "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst), Taeniopygia guttata"
xref: Reactome:REACT_113596 "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst), Xenopus tropicalis"
xref: Reactome:REACT_113760 "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst), Sus scrofa"
xref: Reactome:REACT_113831 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain), Xenopus tropicalis"
xref: Reactome:REACT_114057 "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B, Sus scrofa"
xref: Reactome:REACT_114147 "factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer, Mus musculus"
xref: Reactome:REACT_114209 "factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer, Canis familiaris"
xref: Reactome:REACT_114347 "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides, Xenopus tropicalis"
xref: Reactome:REACT_114464 "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin, Xenopus tropicalis"
xref: Reactome:REACT_115043 "Latent TGF-beta1 is cleaved by furin, Drosophila melanogaster"
xref: Reactome:REACT_115078 "factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer, Danio rerio"
xref: Reactome:REACT_115086 "factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer, Taeniopygia guttata"
xref: Reactome:REACT_115256 "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst), Mus musculus"
xref: Reactome:REACT_115338 "protein C -> activated protein C + protein C heavy chain activation peptide, Xenopus tropicalis"
xref: Reactome:REACT_115742 "Signal peptide cleavage from ribosome-associated nascent protein, Homo sapiens"
xref: Reactome:REACT_118086 "Signal peptide cleavage from ribosome-associated nascent protein, Oryza sativa"
xref: Reactome:REACT_118100 "Signal peptide cleavage from ribosome-associated nascent protein, Xenopus tropicalis"
xref: Reactome:REACT_118128 "Signal peptide cleavage from ribosome-associated nascent protein, Arabidopsis thaliana"
xref: Reactome:REACT_118174 "Signal peptide cleavage from ribosome-associated nascent protein, Caenorhabditis elegans"
xref: Reactome:REACT_118183 "Signal peptide cleavage from ribosome-associated nascent protein, Danio rerio"
xref: Reactome:REACT_118198 "Signal peptide cleavage from ribosome-associated nascent protein, Drosophila melanogaster"
xref: Reactome:REACT_118250 "Signal peptide cleavage from ribosome-associated nascent protein, Dictyostelium discoideum"
xref: Reactome:REACT_118264 "Signal peptide cleavage from ribosome-associated nascent protein, Taeniopygia guttata"
xref: Reactome:REACT_118287 "Signal peptide cleavage from ribosome-associated nascent protein, Gallus gallus"
xref: Reactome:REACT_118304 "Signal peptide cleavage from ribosome-associated nascent protein, Canis familiaris"
xref: Reactome:REACT_118357 "Signal peptide cleavage from ribosome-associated nascent protein, Plasmodium falciparum"
xref: Reactome:REACT_118392 "Signal peptide cleavage from ribosome-associated nascent protein, Mus musculus"
xref: Reactome:REACT_118422 "Signal peptide cleavage from ribosome-associated nascent protein, Rattus norvegicus"
xref: Reactome:REACT_1243 "Notch 3 precursor cleaved to form a heterodimer, Homo sapiens"
xref: Reactome:REACT_1423 "pro-factor VII -> factor VII + factor VII propeptide, Homo sapiens"
xref: Reactome:REACT_1446 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst), Homo sapiens"
xref: Reactome:REACT_1455 "factor XII -> factor XIIa, Homo sapiens"
xref: Reactome:REACT_1456 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin, Homo sapiens"
xref: Reactome:REACT_1500 "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin, Homo sapiens"
xref: Reactome:REACT_15308 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Cathepsin G, Homo sapiens"
xref: Reactome:REACT_1535 "pro-protein Z -> protein Z + protein Z propeptide, Homo sapiens"
xref: Reactome:REACT_1536 "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides, Homo sapiens"
xref: Reactome:REACT_15373 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Thrombin, Homo sapiens"
xref: Reactome:REACT_15374 "Processing of Proinsulin to Insulin, Homo sapiens"
xref: Reactome:REACT_15393 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Plasmin, Homo sapiens"
xref: Reactome:REACT_15465 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Prostate-specific Antigen, Homo sapiens"
xref: Reactome:REACT_158 "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst), Homo sapiens"
xref: Reactome:REACT_1581 "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst), Homo sapiens"
xref: Reactome:REACT_1610 "Granzyme-B activates BID by cleavage, Homo sapiens"
xref: Reactome:REACT_1644 "pro-factor X -> factor X + factor X propeptide, Homo sapiens"
xref: Reactome:REACT_1668 "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst), Homo sapiens"
xref: Reactome:REACT_1676 "Notch 2 precursor cleaved to form a heterodimer, Homo sapiens"
xref: Reactome:REACT_16891 "Extracellular processing of novel PDGFs, Homo sapiens"
xref: Reactome:REACT_17059 "Processing of classical PDGFs, Homo sapiens"
xref: Reactome:REACT_18401 "Cleavage of ATF6-alpha by S1P, Homo sapiens"
xref: Reactome:REACT_1860 "pro-protein S -> protein S + protein S propeptide, Homo sapiens"
xref: Reactome:REACT_19170 "Cleavage of Acyl Proghrelin by Prohormone Convertase 1/3, Homo sapiens"
xref: Reactome:REACT_19296 "Cleavage of the Signal Peptide of Preproghrelin, Homo sapiens"
xref: Reactome:REACT_2004 "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin, Homo sapiens"
xref: Reactome:REACT_2028 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain), Homo sapiens"
xref: Reactome:REACT_20669 "Cleavage of the Signal Peptide of Preprolactin by Signal Peptidase (Canis), Bos taurus"
xref: Reactome:REACT_2073 "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst), Homo sapiens"
xref: Reactome:REACT_2114 "Notch 4 precursor cleaved to form a heterodimer, Homo sapiens"
xref: Reactome:REACT_214 "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B, Homo sapiens"
xref: Reactome:REACT_2146 "pro-protein C -> protein C + protein C propeptide, Homo sapiens"
xref: Reactome:REACT_217 "factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer, Homo sapiens"
xref: Reactome:REACT_2226 "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin, Homo sapiens"
xref: Reactome:REACT_23836 "Processing of ProGip to Gip (mouse), Mus musculus"
xref: Reactome:REACT_23854 "Processing of Proglucagon to Glucagon-like Peptide-1 (7-37) (mouse), Mus musculus"
xref: Reactome:REACT_23859 "Proteolytic Cleavage of Glucagon-like Peptide-1 (GLP-1), Homo sapiens"
xref: Reactome:REACT_23880 "Processing of proGIP to GIP, Homo sapiens"
xref: Reactome:REACT_23888 "Processing of preproGIP to proGIP, Homo sapiens"
xref: Reactome:REACT_23895 "Processing of Proglucagon to Glucagon-like Peptide-1, Homo sapiens"
xref: Reactome:REACT_23907 "Processing of preproGLP-1 to proGLP-1, Homo sapiens"
xref: Reactome:REACT_23940 "Processing of Proglucagon to Glucagon-like Peptide-1 (7-36) (mouse), Mus musculus"
xref: Reactome:REACT_23981 "Proteolytic Cleavage of Glucose-dependent Insulinotropic Polypeptide (GIP), Homo sapiens"
xref: Reactome:REACT_245 "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst), Homo sapiens"
xref: Reactome:REACT_28116 "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst), Mus musculus"
xref: Reactome:REACT_28152 "pro-prothrombin -> prothrombin + prothrombin propeptide, Sus scrofa"
xref: Reactome:REACT_28164 "Part of pro-beta-NGF is processed to mature beta-NGF, Rattus norvegicus"
xref: Reactome:REACT_28332 "Cleavage of ATF6-alpha by S1P, Danio rerio"
xref: Reactome:REACT_28354 "Conversion of C4 into C4a and C4b, Bos taurus"
xref: Reactome:REACT_28382 "pro-GAS6 -> GAS6 + GAS6 propeptide, Canis familiaris"
xref: Reactome:REACT_28391 "pro-protein C -> protein C + protein C propeptide, Taeniopygia guttata"
xref: Reactome:REACT_28533 "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst), Canis familiaris"
xref: Reactome:REACT_28597 "protein C -> activated protein C + protein C heavy chain activation peptide, Rattus norvegicus"
xref: Reactome:REACT_28631 "Processing of classical PDGFs, Xenopus tropicalis"
xref: Reactome:REACT_28673 "Notch 2 precursor cleaved to form a heterodimer, Gallus gallus"
xref: Reactome:REACT_28723 "protein C -> activated protein C + protein C heavy chain activation peptide, Canis familiaris"
xref: Reactome:REACT_28758 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst), Gallus gallus"
xref: Reactome:REACT_28923 "Activation of C1S, Mus musculus"
xref: Reactome:REACT_29316 "pro-factor X -> factor X + factor X propeptide, Xenopus tropicalis"
xref: Reactome:REACT_29593 "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst), Bos taurus"
xref: Reactome:REACT_29596 "Extracellular processing of novel PDGFs, Taeniopygia guttata"
xref: Reactome:REACT_29653 "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin, Gallus gallus"
xref: Reactome:REACT_29792 "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin, Canis familiaris"
xref: Reactome:REACT_29846 "pro-factor X -> factor X + factor X propeptide, Taeniopygia guttata"
xref: Reactome:REACT_29855 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Plasmin, Danio rerio"
xref: Reactome:REACT_29954 "Activation of C1R, Xenopus tropicalis"
xref: Reactome:REACT_30094 "factor V -> factor Va + factor V activation peptide, Taeniopygia guttata"
xref: Reactome:REACT_30232 "Cleavage of the Signal Peptide of Preproghrelin, Mus musculus"
xref: Reactome:REACT_30422 "Notch 4 precursor cleaved to form a heterodimer, Mus musculus"
xref: Reactome:REACT_30489 "Processing of Proinsulin to Insulin, Danio rerio"
xref: Reactome:REACT_30505 "Processing of proGIP to GIP, Bos taurus"
xref: Reactome:REACT_31158 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst), Taeniopygia guttata"
xref: Reactome:REACT_31164 "pro-protein S -> protein S + protein S propeptide, Mus musculus"
xref: Reactome:REACT_31280 "Processing of Proinsulin to Insulin, Xenopus tropicalis"
xref: Reactome:REACT_31419 "Proteolytic Cleavage of Glucagon-like Peptide-1 (GLP-1), Sus scrofa"
xref: Reactome:REACT_31420 "Part of pro-beta-NGF is processed to mature beta-NGF, Taeniopygia guttata"
xref: Reactome:REACT_31582 "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides, Bos taurus"
xref: Reactome:REACT_31786 "pro-GAS6 -> GAS6 + GAS6 propeptide, Bos taurus"
xref: Reactome:REACT_31846 "pro-protein S -> protein S + protein S propeptide, Danio rerio"
xref: Reactome:REACT_32001 "Notch 2 precursor cleaved to form a heterodimer, Canis familiaris"
xref: Reactome:REACT_32108 "Cleavage of Acyl Proghrelin by Prohormone Convertase 1/3, Canis familiaris"
xref: Reactome:REACT_32118 "factor XII -> factor XIIa, Rattus norvegicus"
xref: Reactome:REACT_32241 "Processing of preproGLP-1 to proGLP-1, Rattus norvegicus"
xref: Reactome:REACT_32341 "Activation of C1R, Bos taurus"
xref: Reactome:REACT_32350 "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst), Bos taurus"
xref: Reactome:REACT_32753 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain), Rattus norvegicus"
xref: Reactome:REACT_32785 "Processing of classical PDGFs, Sus scrofa"
xref: Reactome:REACT_32919 "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst), Danio rerio"
xref: Reactome:REACT_32975 "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin, Mus musculus"
xref: Reactome:REACT_32977 "Thrombin-mediated activation of Proteinase-activated receptors, Xenopus tropicalis"
xref: Reactome:REACT_33012 "Processing of classical PDGFs, Mus musculus"
xref: Reactome:REACT_33038 "Activation of C1S, Rattus norvegicus"
xref: Reactome:REACT_33127 "Cleavage of C3 by C3 convertases, Sus scrofa"
xref: Reactome:REACT_33210 "Latent TGF-beta1 is cleaved by furin, Canis familiaris"
xref: Reactome:REACT_33288 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst), Rattus norvegicus"
xref: Reactome:REACT_33326 "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin, Gallus gallus"
xref: Reactome:REACT_33367 "Thrombin-mediated activation of Proteinase-activated receptors, Bos taurus"
xref: Reactome:REACT_33418 "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst), Canis familiaris"
xref: Reactome:REACT_33841 "pro-protein Z -> protein Z + protein Z propeptide, Mus musculus"
xref: Reactome:REACT_33939 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Plasmin, Rattus norvegicus"
xref: Reactome:REACT_33975 "Extracellular processing of novel PDGFs, Bos taurus"
xref: Reactome:REACT_34064 "factor V -> factor Va + factor V activation peptide, Sus scrofa"
xref: Reactome:REACT_34085 "factor VII -> factor VIIa, Rattus norvegicus"
xref: Reactome:REACT_34137 "urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR, Bos taurus"
xref: Reactome:REACT_34159 "Cleavage of Acyl Proghrelin by Prohormone Convertase 1/3, Mus musculus"
xref: Reactome:REACT_34262 "Conversion of C2 into C2a and C2b, Gallus gallus"
xref: Reactome:REACT_34275 "Processing of Proinsulin to Insulin, Bos taurus"
xref: Reactome:REACT_34474 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst), Mus musculus"
xref: Reactome:REACT_34555 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Thrombin, Danio rerio"
xref: Reactome:REACT_34558 "Processing of Proglucagon to Glucagon-like Peptide-1, Gallus gallus"
xref: Reactome:REACT_374 "protein C -> activated protein C + protein C heavy chain activation peptide, Homo sapiens"
xref: Reactome:REACT_37926 "Processing of preproGLP-1 to proGLP-1, Gallus gallus"
xref: Reactome:REACT_41363 "factor VII -> factor VIIa, Canis familiaris"
xref: Reactome:REACT_41656 "Thrombin-mediated activation of Proteinase-activated receptors, Canis familiaris"
xref: Reactome:REACT_420 "pro-factor IX -> factor IX + factor IX propeptide, Homo sapiens"
xref: Reactome:REACT_493 "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst), Homo sapiens"
xref: Reactome:REACT_547 "urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR, Homo sapiens"
xref: Reactome:REACT_598 "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst), Homo sapiens"
xref: Reactome:REACT_59890 "Proteolytic Cleavage of Glucagon-like Peptide-1 (GLP-1), Gallus gallus"
xref: Reactome:REACT_64320 "factor V -> factor Va + factor V activation peptide, Bos taurus"
xref: Reactome:REACT_65367 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Plasmin, Canis familiaris"
xref: Reactome:REACT_6931 "Latent TGF-beta1 is cleaved by furin, Homo sapiens"
xref: Reactome:REACT_708 "factor V -> factor Va + factor V activation peptide, Homo sapiens"
xref: Reactome:REACT_72 "Thrombin-mediated activation of Proteinase-activated receptors, Homo sapiens"
xref: Reactome:REACT_729 "fibrin multimer, crosslinked -> fibrin digestion products (plasmin), Homo sapiens"
xref: Reactome:REACT_739 "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst), Homo sapiens"
xref: Reactome:REACT_75563 "pro-factor X -> factor X + factor X propeptide, Rattus norvegicus"
xref: Reactome:REACT_76942 "Processing of Proinsulin to Insulin, Canis familiaris"
xref: Reactome:REACT_76945 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Cathepsin G, Mus musculus"
xref: Reactome:REACT_76972 "factor V -> factor Va + factor V activation peptide, Gallus gallus"
xref: Reactome:REACT_77116 "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides, Mus musculus"
xref: Reactome:REACT_77208 "pro-factor X -> factor X + factor X propeptide, Mus musculus"
xref: Reactome:REACT_77419 "factor V -> factor Va + factor V activation peptide, Mus musculus"
xref: Reactome:REACT_77528 "Notch 3 precursor cleaved to form a heterodimer, Mus musculus"
xref: Reactome:REACT_77756 "pro-protein C -> protein C + protein C propeptide, Xenopus tropicalis"
xref: Reactome:REACT_77779 "Cleavage of Acyl Proghrelin by Prohormone Convertase 1/3, Gallus gallus"
xref: Reactome:REACT_77797 "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B, Taeniopygia guttata"
xref: Reactome:REACT_77805 "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst), Bos taurus"
xref: Reactome:REACT_77894 "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin, Mus musculus"
xref: Reactome:REACT_77968 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Cathepsin G, Danio rerio"
xref: Reactome:REACT_78022 "pro-factor VII -> factor VII + factor VII propeptide, Xenopus tropicalis"
xref: Reactome:REACT_78188 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst), Sus scrofa"
xref: Reactome:REACT_78229 "factor Va -> factor Vi, Rattus norvegicus"
xref: Reactome:REACT_78374 "pro-protein C -> protein C + protein C propeptide, Rattus norvegicus"
xref: Reactome:REACT_78406 "Thrombin-mediated activation of Proteinase-activated receptors, Danio rerio"
xref: Reactome:REACT_78477 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain), Sus scrofa"
xref: Reactome:REACT_78734 "Extracellular processing of novel PDGFs, Sus scrofa"
xref: Reactome:REACT_78776 "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin, Danio rerio"
xref: Reactome:REACT_78830 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Cathepsin G, Sus scrofa"
xref: Reactome:REACT_79061 "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst), Bos taurus"
xref: Reactome:REACT_79079 "Latent TGF-beta1 is cleaved by furin, Danio rerio"
xref: Reactome:REACT_79192 "Activation of C1S, Sus scrofa"
xref: Reactome:REACT_79426 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin, Sus scrofa"
xref: Reactome:REACT_79431 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin, Gallus gallus"
xref: Reactome:REACT_7948 "C3(H2O):Factor Bb cleaves C3 to C3b and C3a, Homo sapiens"
xref: Reactome:REACT_79486 "Cleavage of C3 by C3 convertases, Canis familiaris"
xref: Reactome:REACT_79539 "Notch 4 precursor cleaved to form a heterodimer, Canis familiaris"
xref: Reactome:REACT_7959 "Conversion of C2 into C2a and C2b, Homo sapiens"
xref: Reactome:REACT_79601 "urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR, Mus musculus"
xref: Reactome:REACT_79616 "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst), Bos taurus"
xref: Reactome:REACT_79687 "Processing of classical PDGFs, Bos taurus"
xref: Reactome:REACT_7977 "Activation of C1S, Homo sapiens"
xref: Reactome:REACT_7978 "Activation of C1R, Homo sapiens"
xref: Reactome:REACT_7981 "Factor D cleaves C3(H2O)-bound Factor B, Homo sapiens"
xref: Reactome:REACT_79835 "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst), Mus musculus"
xref: Reactome:REACT_7986 "Formation of alternate C5 convertase, Homo sapiens"
xref: Reactome:REACT_7989 "Activation of C5, Homo sapiens"
xref: Reactome:REACT_7990 "Cleavage of C3 by C3 convertases, Homo sapiens"
xref: Reactome:REACT_79971 "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst), Gallus gallus"
xref: Reactome:REACT_8002 "Conversion of C4 into C4a and C4b, Homo sapiens"
xref: Reactome:REACT_80078 "Conversion of C4 into C4a and C4b, Mus musculus"
xref: Reactome:REACT_80147 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst), Danio rerio"
xref: Reactome:REACT_8026 "Factor D cleaves C3b-bound Factor B, Homo sapiens"
xref: Reactome:REACT_80346 "Proteolytic Cleavage of Glucose-dependent Insulinotropic Polypeptide (GIP), Mus musculus"
xref: Reactome:REACT_80454 "Processing of preproGLP-1 to proGLP-1, Danio rerio"
xref: Reactome:REACT_80614 "Processing of classical PDGFs, Danio rerio"
xref: Reactome:REACT_80657 "Cleavage of Acyl Proghrelin by Prohormone Convertase 1/3, Bos taurus"
xref: Reactome:REACT_80718 "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides, Taeniopygia guttata"
xref: Reactome:REACT_80779 "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B, Bos taurus"
xref: Reactome:REACT_80788 "Proteolytic Cleavage of Glucose-dependent Insulinotropic Polypeptide (GIP), Rattus norvegicus"
xref: Reactome:REACT_80828 "Proteolytic Cleavage of Glucose-dependent Insulinotropic Polypeptide (GIP), Canis familiaris"
xref: Reactome:REACT_80892 "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst), Mus musculus"
xref: Reactome:REACT_80961 "Cleavage of C3 by C3 convertases, Mus musculus"
xref: Reactome:REACT_81323 "Proteolytic Cleavage of Glucagon-like Peptide-1 (GLP-1), Rattus norvegicus"
xref: Reactome:REACT_81333 "C3(H2O):Factor Bb cleaves C3 to C3b and C3a, Bos taurus"
xref: Reactome:REACT_81337 "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin, Taeniopygia guttata"
xref: Reactome:REACT_81354 "Notch 2 precursor cleaved to form a heterodimer, Rattus norvegicus"
xref: Reactome:REACT_81372 "Part of pro-beta-NGF is processed to mature beta-NGF, Danio rerio"
xref: Reactome:REACT_81541 "Cleavage of ATF6-alpha by S1P, Sus scrofa"
xref: Reactome:REACT_81561 "pro-prothrombin -> prothrombin + prothrombin propeptide, Gallus gallus"
xref: Reactome:REACT_81777 "Activation of C1R, Rattus norvegicus"
xref: Reactome:REACT_81795 "pro-protein C -> protein C + protein C propeptide, Mus musculus"
xref: Reactome:REACT_81849 "Conversion of C4 into C4a and C4b, Xenopus tropicalis"
xref: Reactome:REACT_82153 "Thrombin-mediated activation of Proteinase-activated receptors, Sus scrofa"
xref: Reactome:REACT_82158 "Notch 1 precursor cleaved to form a heterodimer, Taeniopygia guttata"
xref: Reactome:REACT_82372 "pro-protein C -> protein C + protein C propeptide, Bos taurus"
xref: Reactome:REACT_82390 "C3(H2O):Factor Bb cleaves C3 to C3b and C3a, Mus musculus"
xref: Reactome:REACT_82497 "Notch 3 precursor cleaved to form a heterodimer, Rattus norvegicus"
xref: Reactome:REACT_82637 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Plasmin, Gallus gallus"
xref: Reactome:REACT_82647 "pro-protein Z -> protein Z + protein Z propeptide, Bos taurus"
xref: Reactome:REACT_82729 "Proteolytic Cleavage of Glucagon-like Peptide-1 (GLP-1), Xenopus tropicalis"
xref: Reactome:REACT_82816 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst), Danio rerio"
xref: Reactome:REACT_82968 "Cleavage of C3 by C3 convertases, Bos taurus"
xref: Reactome:REACT_83445 "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst), Canis familiaris"
xref: Reactome:REACT_83461 "pro-factor X -> factor X + factor X propeptide, Canis familiaris"
xref: Reactome:REACT_83499 "urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR, Danio rerio"
xref: Reactome:REACT_83770 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Cathepsin G, Bos taurus"
xref: Reactome:REACT_83777 "C3(H2O):Factor Bb cleaves C3 to C3b and C3a, Danio rerio"
xref: Reactome:REACT_84044 "Cleavage of C3 by C3 convertases, Danio rerio"
xref: Reactome:REACT_84046 "Activation of C5, Bos taurus"
xref: Reactome:REACT_84129 "Processing of classical PDGFs, Rattus norvegicus"
xref: Reactome:REACT_84217 "Processing of classical PDGFs, Canis familiaris"
xref: Reactome:REACT_84258 "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B, Mus musculus"
xref: Reactome:REACT_84261 "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B, Xenopus tropicalis"
xref: Reactome:REACT_84305 "pro-factor X -> factor X + factor X propeptide, Sus scrofa"
xref: Reactome:REACT_84322 "pro-protein S -> protein S + protein S propeptide, Canis familiaris"
xref: Reactome:REACT_84434 "Activation of C5, Mus musculus"
xref: Reactome:REACT_84524 "Factor D cleaves C3b-bound Factor B, Sus scrofa"
xref: Reactome:REACT_84531 "factor Va -> factor Vi, Canis familiaris"
xref: Reactome:REACT_84561 "Formation of alternate C5 convertase, Bos taurus"
xref: Reactome:REACT_84599 "Processing of preproGIP to proGIP, Mus musculus"
xref: Reactome:REACT_84623 "Activation of C1R, Mus musculus"
xref: Reactome:REACT_84646 "factor V -> factor Va + factor V activation peptide, Xenopus tropicalis"
xref: Reactome:REACT_84664 "Latent TGF-beta1 is cleaved by furin, Mus musculus"
xref: Reactome:REACT_84693 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain), Mus musculus"
xref: Reactome:REACT_84795 "Conversion of C4 into C4a and C4b, Sus scrofa"
xref: Reactome:REACT_84822 "Cleavage of Acyl Proghrelin by Prohormone Convertase 1/3, Sus scrofa"
xref: Reactome:REACT_85002 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Thrombin, Mus musculus"
xref: Reactome:REACT_85145 "factor VII -> factor VIIa, Xenopus tropicalis"
xref: Reactome:REACT_85207 "pro-protein S -> protein S + protein S propeptide, Taeniopygia guttata"
xref: Reactome:REACT_85433 "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst), Gallus gallus"
xref: Reactome:REACT_85582 "Processing of Proinsulin to Insulin, Mus musculus"
xref: Reactome:REACT_85635 "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin, Gallus gallus"
xref: Reactome:REACT_85732 "pro-protein S -> protein S + protein S propeptide, Bos taurus"
xref: Reactome:REACT_85824 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Plasmin, Sus scrofa"
xref: Reactome:REACT_85897 "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst), Gallus gallus"
xref: Reactome:REACT_85916 "pro-protein C -> protein C + protein C propeptide, Danio rerio"
xref: Reactome:REACT_86048 "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst), Danio rerio"
xref: Reactome:REACT_86053 "pro-factor VII -> factor VII + factor VII propeptide, Mus musculus"
xref: Reactome:REACT_86117 "Granzyme-B activates BID by cleavage, Rattus norvegicus"
xref: Reactome:REACT_86243 "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst), Mus musculus"
xref: Reactome:REACT_86385 "Notch 1 precursor cleaved to form a heterodimer, Xenopus tropicalis"
xref: Reactome:REACT_86440 "Notch 2 precursor cleaved to form a heterodimer, Sus scrofa"
xref: Reactome:REACT_86442 "Notch 3 precursor cleaved to form a heterodimer, Xenopus tropicalis"
xref: Reactome:REACT_86459 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst), Xenopus tropicalis"
xref: Reactome:REACT_86497 "Activation of C1S, Bos taurus"
xref: Reactome:REACT_86530 "urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR, Rattus norvegicus"
xref: Reactome:REACT_86627 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain), Bos taurus"
xref: Reactome:REACT_86670 "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst), Bos taurus"
xref: Reactome:REACT_86747 "pro-factor IX -> factor IX + factor IX propeptide, Bos taurus"
xref: Reactome:REACT_86842 "Notch 3 precursor cleaved to form a heterodimer, Danio rerio"
xref: Reactome:REACT_86885 "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin, Bos taurus"
xref: Reactome:REACT_86898 "factor VII -> factor VIIa, Bos taurus"
xref: Reactome:REACT_86969 "factor XII -> factor XIIa, Mus musculus"
xref: Reactome:REACT_87075 "pro-factor VII -> factor VII + factor VII propeptide, Rattus norvegicus"
xref: Reactome:REACT_87266 "Processing of Proglucagon to Glucagon-like Peptide-1, Danio rerio"
xref: Reactome:REACT_87452 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst), Canis familiaris"
xref: Reactome:REACT_87454 "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst), Danio rerio"
xref: Reactome:REACT_87599 "pro-prothrombin -> prothrombin + prothrombin propeptide, Xenopus tropicalis"
xref: Reactome:REACT_87700 "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst), Rattus norvegicus"
xref: Reactome:REACT_87792 "Activation of C5, Sus scrofa"
xref: Reactome:REACT_87800 "Notch 2 precursor cleaved to form a heterodimer, Xenopus tropicalis"
xref: Reactome:REACT_87920 "Cleavage of ATF6-alpha by S1P, Rattus norvegicus"
xref: Reactome:REACT_88355 "Activation of C5, Danio rerio"
xref: Reactome:REACT_88360 "Extracellular processing of novel PDGFs, Danio rerio"
xref: Reactome:REACT_88496 "Notch 2 precursor cleaved to form a heterodimer, Mus musculus"
xref: Reactome:REACT_88788 "Notch 2 precursor cleaved to form a heterodimer, Danio rerio"
xref: Reactome:REACT_88823 "Part of pro-beta-NGF is processed to mature beta-NGF, Gallus gallus"
xref: Reactome:REACT_88980 "Conversion of C4 into C4a and C4b, Canis familiaris"
xref: Reactome:REACT_89126 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Plasmin, Taeniopygia guttata"
xref: Reactome:REACT_89188 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst), Rattus norvegicus"
xref: Reactome:REACT_89330 "pro-GAS6 -> GAS6 + GAS6 propeptide, Gallus gallus"
xref: Reactome:REACT_89358 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Thrombin, Bos taurus"
xref: Reactome:REACT_89476 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Plasmin, Bos taurus"
xref: Reactome:REACT_89486 "Cleavage of the Signal Peptide of Preproghrelin, Sus scrofa"
xref: Reactome:REACT_89678 "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin, Danio rerio"
xref: Reactome:REACT_89776 "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin, Canis familiaris"
xref: Reactome:REACT_89824 "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin, Rattus norvegicus"
xref: Reactome:REACT_89888 "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin, Canis familiaris"
xref: Reactome:REACT_89976 "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst), Mus musculus"
xref: Reactome:REACT_9 "factor VII -> factor VIIa, Homo sapiens"
xref: Reactome:REACT_90020 "Notch 1 precursor cleaved to form a heterodimer, Gallus gallus"
xref: Reactome:REACT_90057 "Activation of C5, Canis familiaris"
xref: Reactome:REACT_90119 "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst), Gallus gallus"
xref: Reactome:REACT_90443 "Thrombin-mediated activation of Proteinase-activated receptors, Gallus gallus"
xref: Reactome:REACT_905 "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst), Homo sapiens"
xref: Reactome:REACT_90541 "pro-prothrombin -> prothrombin + prothrombin propeptide, Canis familiaris"
xref: Reactome:REACT_90557 "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst), Rattus norvegicus"
xref: Reactome:REACT_90602 "Notch 1 precursor cleaved to form a heterodimer, Bos taurus"
xref: Reactome:REACT_90751 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin, Mus musculus"
xref: Reactome:REACT_90855 "Latent TGF-beta1 is cleaved by furin, Sus scrofa"
xref: Reactome:REACT_90888 "Processing of Proglucagon to Glucagon-like Peptide-1, Bos taurus"
xref: Reactome:REACT_90902 "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin, Bos taurus"
xref: Reactome:REACT_90939 "pro-factor X -> factor X + factor X propeptide, Danio rerio"
xref: Reactome:REACT_91056 "Factor D cleaves C3(H2O)-bound Factor B, Mus musculus"
xref: Reactome:REACT_91167 "Part of pro-beta-NGF is processed to mature beta-NGF, Xenopus tropicalis"
xref: Reactome:REACT_91387 "Extracellular processing of novel PDGFs, Xenopus tropicalis"
xref: Reactome:REACT_91461 "Factor D cleaves C3(H2O)-bound Factor B, Danio rerio"
xref: Reactome:REACT_91543 "Cleavage of the Signal Peptide of Preproghrelin, Canis familiaris"
xref: Reactome:REACT_91726 "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst), Rattus norvegicus"
xref: Reactome:REACT_91877 "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin, Rattus norvegicus"
xref: Reactome:REACT_92031 "factor V -> factor Va + factor V activation peptide, Danio rerio"
xref: Reactome:REACT_92103 "Latent TGF-beta1 is cleaved by furin, Rattus norvegicus"
xref: Reactome:REACT_92110 "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst), Sus scrofa"
xref: Reactome:REACT_92215 "Cleavage of the Signal Peptide of Preproghrelin, Gallus gallus"
xref: Reactome:REACT_92228 "pro-protein S -> protein S + protein S propeptide, Gallus gallus"
xref: Reactome:REACT_92253 "factor V -> factor Va + factor V activation peptide, Rattus norvegicus"
xref: Reactome:REACT_92261 "Notch 4 precursor cleaved to form a heterodimer, Sus scrofa"
xref: Reactome:REACT_92422 "pro-protein S -> protein S + protein S propeptide, Xenopus tropicalis"
xref: Reactome:REACT_92693 "Latent TGF-beta1 is cleaved by furin, Bos taurus"
xref: Reactome:REACT_92748 "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin, Sus scrofa"
xref: Reactome:REACT_92823 "Notch 1 precursor cleaved to form a heterodimer, Canis familiaris"
xref: Reactome:REACT_92949 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Prostate-specific Antigen, Rattus norvegicus"
xref: Reactome:REACT_93064 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain), Gallus gallus"
xref: Reactome:REACT_93142 "pro-factor X -> factor X + factor X propeptide, Bos taurus"
xref: Reactome:REACT_93274 "Processing of Proinsulin to Insulin, Gallus gallus"
xref: Reactome:REACT_93405 "factor VII -> factor VIIa, Mus musculus"
xref: Reactome:REACT_93445 "factor XII -> factor XIIa, Canis familiaris"
xref: Reactome:REACT_93463 "Notch 1 precursor cleaved to form a heterodimer, Drosophila melanogaster"
xref: Reactome:REACT_93480 "factor Va -> factor Vi, Danio rerio"
xref: Reactome:REACT_93511 "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst), Rattus norvegicus"
xref: Reactome:REACT_93561 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain), Taeniopygia guttata"
xref: Reactome:REACT_93736 "pro-GAS6 -> GAS6 + GAS6 propeptide, Rattus norvegicus"
xref: Reactome:REACT_94000 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Thrombin, Rattus norvegicus"
xref: Reactome:REACT_94036 "factor VII -> factor VIIa, Gallus gallus"
xref: Reactome:REACT_94312 "pro-protein Z -> protein Z + protein Z propeptide, Gallus gallus"
xref: Reactome:REACT_94368 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin, Danio rerio"
xref: Reactome:REACT_94599 "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin, Mus musculus"
xref: Reactome:REACT_94754 "factor V -> factor Va + factor V activation peptide, Canis familiaris"
xref: Reactome:REACT_94901 "Processing of preproGIP to proGIP, Canis familiaris"
xref: Reactome:REACT_94902 "Cleavage of Acyl Proghrelin by Prohormone Convertase 1/3, Rattus norvegicus"
xref: Reactome:REACT_94933 "Part of pro-beta-NGF is processed to mature beta-NGF, Canis familiaris"
xref: Reactome:REACT_94955 "Cleavage of ATF6-alpha by S1P, Xenopus tropicalis"
xref: Reactome:REACT_94965 "Formation of alternate C5 convertase, Sus scrofa"
xref: Reactome:REACT_95107 "Thrombin-mediated activation of Proteinase-activated receptors, Rattus norvegicus"
xref: Reactome:REACT_95139 "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst), Canis familiaris"
xref: Reactome:REACT_95191 "pro-protein Z -> protein Z + protein Z propeptide, Xenopus tropicalis"
xref: Reactome:REACT_95211 "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst), Mus musculus"
xref: Reactome:REACT_95236 "Proteolytic Cleavage of Glucagon-like Peptide-1 (GLP-1), Taeniopygia guttata"
xref: Reactome:REACT_95276 "pro-prothrombin -> prothrombin + prothrombin propeptide, Taeniopygia guttata"
xref: Reactome:REACT_95431 "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst), Bos taurus"
xref: Reactome:REACT_95949 "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst), Rattus norvegicus"
xref: Reactome:REACT_95979 "pro-GAS6 -> GAS6 + GAS6 propeptide, Mus musculus"
xref: Reactome:REACT_96137 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain), Canis familiaris"
xref: Reactome:REACT_96193 "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin, Bos taurus"
xref: Reactome:REACT_96270 "pro-factor IX -> factor IX + factor IX propeptide, Xenopus tropicalis"
xref: Reactome:REACT_96343 "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B, Rattus norvegicus"
xref: Reactome:REACT_96382 "Factor D cleaves C3b-bound Factor B, Mus musculus"
xref: Reactome:REACT_96526 "C3(H2O):Factor Bb cleaves C3 to C3b and C3a, Sus scrofa"
xref: Reactome:REACT_97100 "pro-protein Z -> protein Z + protein Z propeptide, Danio rerio"
xref: Reactome:REACT_97110 "factor Va -> factor Vi, Xenopus tropicalis"
xref: Reactome:REACT_97353 "factor XII -> factor XIIa, Bos taurus"
xref: Reactome:REACT_97421 "pro-protein C -> protein C + protein C propeptide, Canis familiaris"
xref: Reactome:REACT_97432 "Part of pro-beta-NGF is processed to mature beta-NGF, Bos taurus"
xref: Reactome:REACT_97564 "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin, Taeniopygia guttata"
xref: Reactome:REACT_97673 "pro-factor VII -> factor VII + factor VII propeptide, Bos taurus"
xref: Reactome:REACT_97699 "pro-GAS6 -> GAS6 + GAS6 propeptide, Xenopus tropicalis"
xref: Reactome:REACT_97708 "Cleavage of ATF6-alpha by S1P, Bos taurus"
xref: Reactome:REACT_97710 "Cleavage of ATF6-alpha by S1P, Mus musculus"
xref: Reactome:REACT_97801 "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin, Sus scrofa"
xref: Reactome:REACT_97855 "urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR, Canis familiaris"
xref: Reactome:REACT_98063 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Cathepsin G, Rattus norvegicus"
xref: Reactome:REACT_98097 "Activation of C1S, Xenopus tropicalis"
xref: Reactome:REACT_98147 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Thrombin, Gallus gallus"
xref: Reactome:REACT_98165 "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin, Xenopus tropicalis"
xref: Reactome:REACT_98203 "pro-GAS6 -> GAS6 + GAS6 propeptide, Danio rerio"
xref: Reactome:REACT_98267 "pro-prothrombin -> prothrombin + prothrombin propeptide, Rattus norvegicus"
xref: Reactome:REACT_98357 "pro-prothrombin -> prothrombin + prothrombin propeptide, Danio rerio"
xref: Reactome:REACT_98392 "Extracellular processing of novel PDGFs, Rattus norvegicus"
xref: Reactome:REACT_98494 "Processing of preproGLP-1 to proGLP-1, Taeniopygia guttata"
xref: Reactome:REACT_98565 "Processing of preproGIP to proGIP, Rattus norvegicus"
xref: Reactome:REACT_98659 "Factor D cleaves C3(H2O)-bound Factor B, Sus scrofa"
xref: Reactome:REACT_98696 "pro-prothrombin -> prothrombin + prothrombin propeptide, Bos taurus"
xref: Reactome:REACT_98749 "Proteolytic Cleavage of Glucose-dependent Insulinotropic Polypeptide (GIP), Bos taurus"
xref: Reactome:REACT_98786 "Notch 3 precursor cleaved to form a heterodimer, Bos taurus"
xref: Reactome:REACT_98917 "Formation of alternate C5 convertase, Canis familiaris"
xref: Reactome:REACT_99191 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Plasmin, Mus musculus"
xref: Reactome:REACT_99384 "Processing of classical PDGFs, Taeniopygia guttata"
xref: Reactome:REACT_99395 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst), Canis familiaris"
xref: Reactome:REACT_99405 "Notch 4 precursor cleaved to form a heterodimer, Rattus norvegicus"
xref: Reactome:REACT_99429 "Processing of Proglucagon to Glucagon-like Peptide-1, Xenopus tropicalis"
xref: Reactome:REACT_99443 "Cleavage of the Signal Peptide of Preproghrelin, Rattus norvegicus"
xref: Reactome:REACT_99555 "pro-protein Z -> protein Z + protein Z propeptide, Taeniopygia guttata"
xref: Reactome:REACT_99585 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin, Rattus norvegicus"
xref: Reactome:REACT_99900 "protein C -> activated protein C + protein C heavy chain activation peptide, Mus musculus"
xref: Reactome:REACT_99921 "Granzyme-B activates BID by cleavage, Bos taurus"
xref: Reactome:REACT_99987 "Notch 2 precursor cleaved to form a heterodimer, Bos taurus"
is_a: GO:0004175 ! endopeptidase activity
is_a: GO:0008236 ! serine-type peptidase activity

[Term]
id: GO:0004253
name: obsolete gamma-renin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of the Leu-Leu bond in synthetic tetradecapeptide renin substrate, producing angiotensin I, but not active on natural angiotensinogen. Also hydrolyzes BZ-Arg-para-nitroanilide." [EC:3.4.21.54]
comment: This term was made obsolete because it represents a gene product.
synonym: "gamma-renin activity" EXACT []
xref: EC:3.4.21.54
xref: MetaCyc:3.4.21.54-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004254
name: obsolete acylaminoacyl-peptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: acylaminoacyl-peptide + H2O = acylamino acid + peptide." [EC:3.4.19.1]
subset: gosubset_prok
synonym: "acylamino-acid-releasing enzyme activity" EXACT [EC:3.4.19.1]
synonym: "acylaminoacyl-peptidase activity" EXACT []
synonym: "alpha-N-acylpeptide hydrolase activity" EXACT [EC:3.4.19.1]
synonym: "N-acylpeptide hydrolase activity" EXACT [EC:3.4.19.1]
synonym: "N-formylmethionine (fMet) aminopeptidase activity" EXACT [EC:3.4.19.1]
xref: EC:3.4.19.1
xref: MetaCyc:ACYLAMINOACYL-PEPTIDASE-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004258
name: obsolete vacuolar carboxypeptidase Y
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of a C-terminal amino acid with a broad specificity." [EC:3.4.16.5]
comment: This term was made obsolete because it contains both component and function information.
synonym: "vacuolar carboxypeptidase Y" EXACT []
is_obsolete: true
consider: GO:0004185
consider: GO:0005773

[Term]
id: GO:0004261
name: obsolete cathepsin G activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity similar to chymotrypsin C." [EC:3.4.21.20]
comment: This term was made obsolete because it represents a gene product.
synonym: "cathepsin G activity" EXACT []
synonym: "chymotrypsin-like proteinase activity" EXACT [EC:3.4.21.20]
synonym: "neutral proteinase activity" EXACT [EC:3.4.21.20]
xref: EC:3.4.21.20
xref: MetaCyc:3.4.21.20-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004262
name: obsolete cerevisin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity, and of BZ-Arg-OET > Ac-Tyr-OET. Does not hydrolyze peptide amides." [EC:3.4.21.48]
comment: This term was made obsolete because it represents a gene product.
synonym: "baker's yeast proteinase B" RELATED [EC:3.4.21.48]
synonym: "brewer's yeast proteinase" NARROW [EC:3.4.21.48]
synonym: "cerevisin activity" EXACT []
synonym: "peptidase beta" RELATED [EC:3.4.21.48]
synonym: "proteinase yscB activity" NARROW [EC:3.4.21.48]
synonym: "yeast proteinase B activity" NARROW [EC:3.4.21.48]
xref: EC:3.4.21.48
xref: MetaCyc:3.4.21.48-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004263
name: obsolete chymotrypsin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the preferential cleavage of Tyr-Xaa > Trp-Xaa > Phe-Xaa > Leu-Xaa." [EC:3.4.21.1, ISBN:0198506732]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "alpha-chymar" RELATED [EC:3.4.21.1]
synonym: "alpha-chymar ophth" RELATED [EC:3.4.21.1]
synonym: "alpha-chymotrypsin A" RELATED [EC:3.4.21.1]
synonym: "alpha-chymotrypsin activity" NARROW [EC:3.4.21.1]
synonym: "avazyme" RELATED [EC:3.4.21.1]
synonym: "chymar" RELATED [EC:3.4.21.1]
synonym: "chymotest" RELATED [EC:3.4.21.1]
synonym: "chymotrypsin A activity" NARROW [EC:3.4.21.1]
synonym: "chymotrypsin activity" EXACT []
synonym: "chymotrypsin B activity" NARROW [EC:3.4.21.1]
synonym: "chymotrypsins A and B" RELATED [EC:3.4.21.1]
synonym: "enzeon" RELATED [EC:3.4.21.1]
synonym: "quimar" RELATED [EC:3.4.21.1]
synonym: "quimotrase activity" EXACT [EC:3.4.21.1]
xref: EC:3.4.21.1
xref: MetaCyc:3.4.21.1-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004274
name: obsolete dipeptidyl-peptidase IV activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of an N-terminal dipeptide, by the hydrolysis of the Xbb-Xcc bond in Xaa-Xbb-Xcc, preferentially when Xbb is Pro, provided Xcc is neither Pro nor hydroxyproline." [EC:3.4.14.5]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "amino acyl-prolyl dipeptidyl aminopeptidase activity" EXACT [EC:3.4.14.5]
synonym: "dipeptidyl aminopeptidase IV activity" EXACT [EC:3.4.14.5]
synonym: "dipeptidyl peptidase IV" RELATED [EC:3.4.14.5]
synonym: "dipeptidyl-aminopeptidase IV" RELATED [EC:3.4.14.5]
synonym: "dipeptidyl-peptidase IV activity" EXACT []
synonym: "dipeptidyl-peptide hydrolase activity" EXACT [EC:3.4.14.5]
synonym: "DPP IV activity" EXACT [EC:3.4.14.5]
synonym: "DPP IV/CD26" RELATED [EC:3.4.14.5]
synonym: "Gly-Pro naphthylamidase activity" EXACT [EC:3.4.14.5]
synonym: "glycoprotein GP110" RELATED [EC:3.4.14.5]
synonym: "glycylproline aminopeptidase activity" EXACT [EC:3.4.14.5]
synonym: "glycylprolyl aminopeptidase activity" EXACT [EC:3.4.14.5]
synonym: "glycylprolyl dipeptidylaminopeptidase activity" EXACT [EC:3.4.14.5]
synonym: "leukocyte antigen CD26" RELATED [EC:3.4.14.5]
synonym: "lymphocyte antigen CD26" RELATED [EC:3.4.14.5]
synonym: "pep X" RELATED [EC:3.4.14.5]
synonym: "post-proline dipeptidyl aminopeptidase IV activity" EXACT [EC:3.4.14.5]
synonym: "postproline dipeptidyl aminopeptidase IV" RELATED [EC:3.4.14.5]
synonym: "T cell triggering molecule Tp103" RELATED [EC:3.4.14.5]
synonym: "X-PDAP" RELATED [EC:3.4.14.5]
synonym: "Xaa-Pro-dipeptidyl-aminopeptidase activity" EXACT [EC:3.4.14.5]
synonym: "Xaa-Pro-dipeptidylaminopeptidase activity" EXACT [EC:3.4.14.5]
xref: EC:3.4.14.5
xref: MetaCyc:3.4.14.5-RXN
is_obsolete: true
consider: GO:0008236
consider: GO:0008239

[Term]
id: GO:0004275
name: obsolete enteropeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the selective cleavage of Lys6-Ile7 bond in trypsinogen." [EC:3.4.21.9]
comment: This term was made obsolete because it represents a gene product.
synonym: "enterokinase activity" RELATED [EC:3.4.21.9]
synonym: "enteropeptidase activity" EXACT []
xref: EC:3.4.21.9
xref: MetaCyc:3.4.21.9-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004276
name: obsolete furin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of mature proteins from their proproteins by cleavage of the terminal bond of Arg-Xaa-Yaa-Arg-Z motifs where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors." [EC:3.4.21.75]
comment: This term was made obsolete because it represents a gene product.
synonym: "dibasic processing enzyme activity" EXACT [EC:3.4.21.75]
synonym: "furin activity" EXACT []
synonym: "PACE" RELATED [EC:3.4.21.75]
synonym: "paired basic amino acid cleaving enzyme" RELATED [EC:3.4.21.75]
synonym: "paired basic amino acid converting enzyme" RELATED [EC:3.4.21.75]
synonym: "paired basic amino acid residue cleaving enzyme activity" EXACT [EC:3.4.21.75]
synonym: "prohormone convertase activity" NARROW [EC:3.4.21.75]
synonym: "serine proteinase PACE" RELATED [EC:3.4.21.75]
synonym: "SPC3" RELATED [EC:3.4.21.75]
xref: EC:3.4.21.75
xref: MetaCyc:3.4.21.75-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004277
name: obsolete granzyme A activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: Arg-Xaa > Lys-Xaa > Phe-Xaa in small molecule substrates." [EC:3.4.21.78]
comment: This term was made obsolete because it represents a gene product.
synonym: "CTLA3" RELATED [EC:3.4.21.78]
synonym: "cytotoxic T lymphocyte serine protease" NARROW [EC:3.4.21.78]
synonym: "cytotoxic T-lymphocyte proteinase 1 activity" NARROW [EC:3.4.21.78]
synonym: "granzyme A activity" EXACT []
synonym: "HuTPS" RELATED [EC:3.4.21.78]
synonym: "T-cell associated protease 1" RELATED [EC:3.4.21.78]
synonym: "T-cell derived serine proteinase" NARROW [EC:3.4.21.78]
synonym: "TSP-1" RELATED [EC:3.4.21.78]
xref: EC:3.4.21.78
xref: MetaCyc:3.4.21.78-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004278
name: obsolete granzyme B activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the preferential cleavage of Asp-Xaa > Asn-Xaa > Met-Xaa, Ser-Xaa." [EC:3.4.21.79]
comment: This term was made obsolete because it represents a gene product.
synonym: "CCP1 proteinase" NARROW [EC:3.4.21.79]
synonym: "CCPII" RELATED [EC:3.4.21.79]
synonym: "CTLA1" RELATED [EC:3.4.21.79]
synonym: "cytotoxic cell proteinase-1" RELATED [EC:3.4.21.79]
synonym: "cytotoxic t-lymphocyte proteinase 2 activity" NARROW [EC:3.4.21.79]
synonym: "granzyme B activity" EXACT []
synonym: "granzyme G" RELATED [EC:3.4.21.79]
synonym: "granzyme H" RELATED [EC:3.4.21.79]
xref: EC:3.4.21.79
xref: MetaCyc:3.4.21.79-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004281
name: obsolete pancreatic elastase II activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the preferential cleavage of Leu-Xaa, Met-Xaa and Phe-Xaa. Hydrolyzes elastin." [EC:3.4.21.71]
comment: This term was made obsolete because it represents a gene product.
synonym: "pancreatic elastase 2" RELATED [EC:3.4.21.71]
synonym: "pancreatic elastase II activity" EXACT []
xref: EC:3.4.21.71
xref: MetaCyc:3.4.21.71-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004283
name: obsolete plasmin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the preferential cleavage of Lys-Xaa > Arg-Xaa; higher selectivity than trypsin. Converts fibrin into soluble products." [EC:3.4.21.7]
comment: This term was made obsolete because it represents a gene product.
synonym: "actase activity" EXACT [EC:3.4.21.7]
synonym: "fibrinase activity" EXACT [EC:3.4.21.7]
synonym: "fibrinolysin activity" EXACT [EC:3.4.21.7]
synonym: "plasmin activity" EXACT []
synonym: "serum tryptase activity" EXACT [EC:3.4.21.7]
synonym: "thrombolysin" RELATED [EC:3.4.21.7]
xref: EC:3.4.21.7
xref: MetaCyc:3.4.21.7-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004284
name: obsolete acrosin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa > Lys-Xaa." [EC:3.4.21.10]
comment: This term was made obsolete because it represents a gene product.
synonym: "acrosin activity" EXACT []
synonym: "acrosin amidase activity" EXACT [EC:3.4.21.10]
synonym: "acrosomal protease activity" EXACT [EC:3.4.21.10]
synonym: "acrosomal proteinase activity" EXACT [EC:3.4.21.10]
synonym: "acrozonase activity" EXACT [EC:3.4.21.10]
synonym: "alpha-acrosin" RELATED [EC:3.4.21.10]
synonym: "beta-acrosin" RELATED [EC:3.4.21.10]
synonym: "psi-acrosin" RELATED [EC:3.4.21.10]
xref: EC:3.4.21.10
xref: MetaCyc:3.4.21.10-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004285
name: obsolete proprotein convertase 1 activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of protein hormones, neuropeptides and renin from their precursors, generally by cleavage of -Lys-Arg-Xaa at the Arg-Xaa bond." [EC:3.4.21.93]
comment: This term was made obsolete because it represents a gene product.
synonym: "NEC 1 activity" NARROW [EC:3.4.21.93]
synonym: "neuroendocrine convertase 1 activity" NARROW [EC:3.4.21.93]
synonym: "PC1 activity" NARROW [EC:3.4.21.93]
synonym: "prohormone convertase 3" RELATED [EC:3.4.21.93]
synonym: "prohormone convertase I activity" NARROW [EC:3.4.21.93]
synonym: "proprotein convertase 1 activity" EXACT []
xref: EC:3.4.21.93
xref: MetaCyc:3.4.21.93-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004286
name: obsolete proprotein convertase 2 activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of protein hormones and neuropeptides from their precursors, generally by cleavage of -Lys-Arg-Xaa at the Arg-Xaa bond." [EC:3.4.21.94]
comment: This term was made obsolete because it represents a gene product.
synonym: "NEC 2 activity" NARROW [EC:3.4.21.94]
synonym: "neuroendocrine convertase 2 activity" NARROW [EC:3.4.21.94]
synonym: "PC2 activity" NARROW [EC:3.4.21.94]
synonym: "prohormone convertase II activity" NARROW [EC:3.4.21.94]
synonym: "proprotein convertase 2 activity" EXACT []
xref: EC:3.4.21.94
xref: MetaCyc:3.4.21.94-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004287
name: obsolete prolyl oligopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of Pro-Xaa > Ala-Xaa in oligopeptides." [EC:3.4.21.26]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "endoprolylpeptidase activity" EXACT [EC:3.4.21.26]
synonym: "post-proline cleaving enzyme activity" EXACT [EC:3.4.21.26]
synonym: "post-proline endopeptidase activity" EXACT [EC:3.4.21.26]
synonym: "proline endopeptidase activity" EXACT [EC:3.4.21.26]
synonym: "proline-specific endopeptidase activity" EXACT [EC:3.4.21.26]
synonym: "prolyl endopeptidase activity" EXACT [EC:3.4.21.26]
synonym: "prolyl oligopeptidase activity" EXACT []
xref: EC:3.4.21.26
xref: MetaCyc:3.4.21.26-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004289
name: obsolete subtilase activity
namespace: molecular_function
def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "subtilase activity" EXACT []
xref: EC:3.4.21.-
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004290
name: obsolete kexin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of the Arg-Xaa bond in Lys-Arg-Xaa and Arg-Arg-Xaa to process Yeast alpha-factor pheromone and killer toxin precursors." [EC:3.4.21.61]
comment: This term was made obsolete because it represents a gene product.
synonym: "andrenorphin-Gly-generating enzyme" RELATED [EC:3.4.21.61]
synonym: "endoproteinase Kex2p" RELATED [EC:3.4.21.61]
synonym: "gene KEX2 dibasic proteinase" NARROW [EC:3.4.21.61]
synonym: "Kex 2p proteinase" NARROW [EC:3.4.21.61]
synonym: "Kex2 endopeptidase" NARROW [EC:3.4.21.61]
synonym: "Kex2 endoprotease" NARROW [EC:3.4.21.61]
synonym: "Kex2 endoproteinase" NARROW [EC:3.4.21.61]
synonym: "Kex2 protease" NARROW [EC:3.4.21.61]
synonym: "Kex2 proteinase" NARROW [EC:3.4.21.61]
synonym: "Kex2-like endoproteinase" NARROW [EC:3.4.21.61]
synonym: "Kex2-like precursor protein processing endoprotease" NARROW [EC:3.4.21.61]
synonym: "kexin activity" EXACT []
synonym: "paired-basic endopeptidase activity" EXACT [EC:3.4.21.61]
synonym: "prohormone-processing endoprotease activity" RELATED [EC:3.4.21.61]
synonym: "prohormone-processing KEX2 proteinase" NARROW [EC:3.4.21.61]
synonym: "prohormone-processing proteinase activity" EXACT [EC:3.4.21.61]
synonym: "protease KEX2" RELATED [EC:3.4.21.61]
synonym: "proteinase Kex2p" RELATED [EC:3.4.21.61]
synonym: "proteinase yscF activity" NARROW [EC:3.4.21.61]
synonym: "yeast cysteine proteinase F" RELATED [EC:3.4.21.61]
synonym: "yeast KEX2 protease activity" NARROW [EC:3.4.21.61]
xref: EC:3.4.21.61
xref: MetaCyc:3.4.21.61-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004291
name: obsolete subtilisin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides." [EC:3.4.21.62]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "alcalase 0.6L" RELATED [EC:3.4.21.62]
synonym: "alcalase 2.5L" RELATED [EC:3.4.21.62]
synonym: "alcalase activity" EXACT [EC:3.4.21.62]
synonym: "ALK-enzyme" RELATED [EC:3.4.21.62]
synonym: "bacillopeptidase A" RELATED [EC:3.4.21.62]
synonym: "bacillopeptidase B" RELATED [EC:3.4.21.62]
synonym: "bacillus subtilis alkaline proteinase activity" EXACT [EC:3.4.21.62]
synonym: "bacillus subtilis alkaline proteinase bioprase activity" EXACT [EC:3.4.21.62]
synonym: "bioprase AL 15" RELATED [EC:3.4.21.62]
synonym: "bioprase APL 30" RELATED [EC:3.4.21.62]
synonym: "colistinase activity" EXACT [EC:3.4.21.62]
synonym: "esperase activity" EXACT [EC:3.4.21.62]
synonym: "genenase I" RELATED [EC:3.4.21.62]
synonym: "kazusase activity" EXACT [EC:3.4.21.62]
synonym: "maxatase activity" EXACT [EC:3.4.21.62]
synonym: "opticlean" RELATED [EC:3.4.21.62]
synonym: "orientase 10B" RELATED [EC:3.4.21.62]
synonym: "protease S" RELATED [EC:3.4.21.62]
synonym: "protease VIII" RELATED [EC:3.4.21.62]
synonym: "protease XXVII" RELATED [EC:3.4.21.62]
synonym: "protin A 3L" RELATED [EC:3.4.21.62]
synonym: "savinase 16.0L" RELATED [EC:3.4.21.62]
synonym: "savinase 32.0 L EX" RELATED [EC:3.4.21.62]
synonym: "savinase 4.0T" RELATED [EC:3.4.21.62]
synonym: "savinase 8.0L" RELATED [EC:3.4.21.62]
synonym: "savinase activity" EXACT [EC:3.4.21.62]
synonym: "SP 266" RELATED [EC:3.4.21.62]
synonym: "subtilisin activity" EXACT []
synonym: "subtilisin BL" RELATED [EC:3.4.21.62]
synonym: "subtilisin DY" RELATED [EC:3.4.21.62]
synonym: "subtilisin E" RELATED [EC:3.4.21.62]
synonym: "subtilisin GX" RELATED [EC:3.4.21.62]
synonym: "subtilisin J" RELATED [EC:3.4.21.62]
synonym: "subtilisin S41" RELATED [EC:3.4.21.62]
synonym: "subtilisin sendai" RELATED [EC:3.4.21.62]
synonym: "subtilopeptidase activity" EXACT [EC:3.4.21.62]
synonym: "superase activity" EXACT [EC:3.4.21.62]
synonym: "thermoase" BROAD [EC:3.4.21.62]
synonym: "thermoase PC 10" RELATED [EC:3.4.21.62]
xref: EC:3.4.21.62
xref: MetaCyc:3.4.21.62-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004293
name: obsolete tissue kallikrein activity
namespace: molecular_function
alt_id: GO:0004279
def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-Xaa or Leu-Xaa. The rat enzyme is unusual in liberating bradykinin directly from autologous kininogens by cleavage at two Arg-Xaa bonds." [EC:3.4.21.35]
comment: This term was made obsolete because it represents a gene product.
synonym: "bradykininogenase" BROAD [EC:3.4.21.35]
synonym: "callicrein" RELATED [EC:3.4.21.35]
synonym: "depot-padutin" RELATED [EC:3.4.21.35]
synonym: "dilminal D" RELATED [EC:3.4.21.35]
synonym: "glandular kallikrein activity" RELATED [EC:3.4.21.35]
synonym: "glumorin" RELATED [EC:3.4.21.35]
synonym: "kallidinogenase" BROAD [EC:3.4.21.35]
synonym: "kallikrein" RELATED [EC:3.4.21.35]
synonym: "kidney kallikrein" RELATED [EC:3.4.21.35]
synonym: "kininogenase" BROAD [EC:3.4.21.35]
synonym: "kininogenin activity" RELATED [EC:3.4.21.35]
synonym: "onokrein P" RELATED [EC:3.4.21.35]
synonym: "padreatin" RELATED [EC:3.4.21.35]
synonym: "padutin" RELATED [EC:3.4.21.35]
synonym: "pancreatic kallikrein" RELATED [EC:3.4.21.35]
synonym: "salivary kallikrein" RELATED [EC:3.4.21.35]
synonym: "submandibular kallikrein" RELATED [EC:3.4.21.35]
synonym: "submaxillary kallikrein" RELATED [EC:3.4.21.35]
synonym: "tissue kallikrein activity" EXACT []
synonym: "urinary kallikrein" RELATED [EC:3.4.21.35]
synonym: "urokallikrein" RELATED [EC:3.4.21.35]
xref: EC:3.4.21.35
xref: MetaCyc:3.4.21.35-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004294
name: obsolete tripeptidyl-peptidase II activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of an N-terminal tripeptide from a polypeptide at neutral pH." [EC:3.4.14.10]
comment: This term was made obsolete because it represents a gene product.
synonym: "TPP" RELATED [EC:3.4.14.10]
synonym: "tripeptidyl aminopeptidase activity" BROAD [EC:3.4.14.10]
synonym: "tripeptidyl aminopeptidase II" RELATED [EC:3.4.14.10]
synonym: "tripeptidyl peptidase activity" BROAD [EC:3.4.14.10]
synonym: "tripeptidyl peptidase II" RELATED [EC:3.4.14.10]
synonym: "tripeptidyl-peptidase II activity" EXACT []
xref: EC:3.4.14.10
xref: MetaCyc:3.4.14.10-RXN
is_obsolete: true
replaced_by: GO:0008240

[Term]
id: GO:0004295
name: obsolete trypsin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa, Lys-Xaa." [EC:3.4.21.4]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "alpha-trypsin activity" NARROW [EC:3.4.21.4]
synonym: "beta-trypsin activity" NARROW [EC:3.4.21.4]
synonym: "cocoonase activity" EXACT [EC:3.4.21.4]
synonym: "parenzyme" RELATED [EC:3.4.21.4]
synonym: "parenzymol" RELATED [EC:3.4.21.4]
synonym: "pseudotrypsin" RELATED [EC:3.4.21.4]
synonym: "sperm receptor hydrolase activity" EXACT [EC:3.4.21.4]
synonym: "tripcellim" RELATED [EC:3.4.21.4]
synonym: "trypsin activity" EXACT []
synonym: "tryptar" RELATED [EC:3.4.21.4]
synonym: "trypure" RELATED [EC:3.4.21.4]
xref: EC:3.4.21.4
xref: MetaCyc:3.4.21.4-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004298
name: threonine-type endopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
subset: gosubset_prok
synonym: "26S protease" RELATED [EC:3.4.25]
synonym: "alkaline protease" RELATED [EC:3.4.25]
synonym: "ingensin" RELATED [EC:3.4.25]
synonym: "large multicatalytic protease" NARROW [EC:3.4.25]
synonym: "lens neutral proteinase" NARROW [EC:3.4.25]
synonym: "MCP" RELATED [EC:3.4.25]
synonym: "multicatalytic endopeptidase complex" RELATED [EC:3.4.25]
synonym: "multicatalytic proteinase" NARROW [EC:3.4.25]
synonym: "multicatalytic proteinase (complex)" NARROW [EC:3.4.25]
synonym: "prosome" RELATED [EC:3.4.25]
synonym: "proteasome endopeptidase complex" NARROW [EC:3.4.25]
synonym: "threonine endopeptidase activity" EXACT []
synonym: "tricorn protease" NARROW [EC:3.4.25]
synonym: "tricorn proteinase" NARROW [EC:3.4.25]
xref: EC:3.4.25
is_a: GO:0004175 ! endopeptidase activity
is_a: GO:0070003 ! threonine-type peptidase activity

[Term]
id: GO:0004299
name: obsolete proteasome endopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage at peptide bonds with very broad specificity." [EC:3.4.25.1]
comment: This term was made obsolete because it mentions a component term in the text string.
synonym: "multicatalytic endopeptidase" RELATED []
synonym: "proteasome" RELATED []
synonym: "proteasome endopeptidase activity" EXACT []
synonym: "proteasome endopeptidase complex" RELATED []
is_obsolete: true
consider: GO:0004175
consider: GO:0008233

[Term]
id: GO:0004300
name: enoyl-CoA hydratase activity
namespace: molecular_function
alt_id: GO:0016510
def: "Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2-enoyl-CoA + H2O." [EC:4.2.1.17]
subset: gosubset_prok
synonym: "(3S)-3-hydroxyacyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.17]
synonym: "2-enoyl-CoA hydratase activity" EXACT [EC:4.2.1.17]
synonym: "2-octenoyl coenzyme A hydrase activity" EXACT [EC:4.2.1.17]
synonym: "acyl coenzyme A hydrase activity" EXACT [EC:4.2.1.17]
synonym: "beta-hydroxyacid dehydrase activity" EXACT [EC:4.2.1.17]
synonym: "beta-hydroxyacyl-CoA dehydrase activity" EXACT [EC:4.2.1.17]
synonym: "crotonyl hydrase activity" EXACT [EC:4.2.1.17]
synonym: "D-3-hydroxyacyl-CoA dehydratase" BROAD [EC:4.2.1.17]
synonym: "ECH" RELATED [EC:4.2.1.17]
synonym: "enol-CoA hydratase activity" EXACT [EC:4.2.1.17]
synonym: "enoyl coenzyme A hydrase (D)" BROAD [EC:4.2.1.17]
synonym: "enoyl coenzyme A hydrase (L)" EXACT [EC:4.2.1.17]
synonym: "enoyl coenzyme A hydratase activity" EXACT [EC:4.2.1.17]
synonym: "enoyl hydrase activity" EXACT [EC:4.2.1.17]
synonym: "hydratase, enoyl coenzyme A" EXACT [EC:4.2.1.17]
synonym: "short chain enoyl coenzyme A hydratase activity" EXACT [EC:4.2.1.17]
synonym: "short-chain enoyl-CoA hydratase activity" EXACT []
synonym: "trans-2-enoyl-CoA hydratase activity" EXACT [EC:4.2.1.17]
synonym: "unsaturated acyl-CoA hydratase activity" EXACT [EC:4.2.1.17]
xref: EC:4.2.1.17
xref: MetaCyc:ENOYL-COA-HYDRAT-RXN
xref: Reactome:REACT_100244 "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA, Escherichia coli"
xref: Reactome:REACT_101009 "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA, Taeniopygia guttata"
xref: Reactome:REACT_102396 "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA, Canis familiaris"
xref: Reactome:REACT_103471 "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA, Caenorhabditis elegans"
xref: Reactome:REACT_103986 "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA, Xenopus tropicalis"
xref: Reactome:REACT_104078 "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA, Rattus norvegicus"
xref: Reactome:REACT_104151 "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA, Escherichia coli"
xref: Reactome:REACT_104418 "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA, Mycobacterium tuberculosis"
xref: Reactome:REACT_104448 "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA, Drosophila melanogaster"
xref: Reactome:REACT_105085 "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA, Xenopus tropicalis"
xref: Reactome:REACT_105300 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Sus scrofa"
xref: Reactome:REACT_105444 "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA, Escherichia coli"
xref: Reactome:REACT_105604 "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA, Xenopus tropicalis"
xref: Reactome:REACT_106492 "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA, Rattus norvegicus"
xref: Reactome:REACT_106863 "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA, Xenopus tropicalis"
xref: Reactome:REACT_107470 "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA, Gallus gallus"
xref: Reactome:REACT_107615 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Danio rerio"
xref: Reactome:REACT_107774 "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA, Taeniopygia guttata"
xref: Reactome:REACT_107955 "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA, Bos taurus"
xref: Reactome:REACT_1081 "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA, Homo sapiens"
xref: Reactome:REACT_108453 "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA, Caenorhabditis elegans"
xref: Reactome:REACT_109 "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA, Homo sapiens"
xref: Reactome:REACT_109467 "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA, Danio rerio"
xref: Reactome:REACT_110285 "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA, Mycobacterium tuberculosis"
xref: Reactome:REACT_110603 "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA, Canis familiaris"
xref: Reactome:REACT_110864 "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA, Drosophila melanogaster"
xref: Reactome:REACT_1513 "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA, Homo sapiens"
xref: Reactome:REACT_1582 "tiglyl-CoA + H2O <=> alpha-methyl-beta-hydroxybutyryl-CoA, Homo sapiens"
xref: Reactome:REACT_2238 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Homo sapiens"
xref: Reactome:REACT_28724 "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA, Rattus norvegicus"
xref: Reactome:REACT_28770 "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA, Escherichia coli"
xref: Reactome:REACT_29458 "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA, Danio rerio"
xref: Reactome:REACT_297 "methacrylyl-CoA + H2O <=> beta-hydroxyisobutyryl-CoA, Homo sapiens"
xref: Reactome:REACT_31820 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Rattus norvegicus"
xref: Reactome:REACT_32105 "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA, Caenorhabditis elegans"
xref: Reactome:REACT_32676 "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA, Drosophila melanogaster"
xref: Reactome:REACT_32695 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Danio rerio"
xref: Reactome:REACT_32816 "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA, Drosophila melanogaster"
xref: Reactome:REACT_32949 "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA, Sus scrofa"
xref: Reactome:REACT_33031 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Sus scrofa"
xref: Reactome:REACT_33248 "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA, Drosophila melanogaster"
xref: Reactome:REACT_33368 "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA, Taeniopygia guttata"
xref: Reactome:REACT_33412 "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA, Canis familiaris"
xref: Reactome:REACT_33601 "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA, Danio rerio"
xref: Reactome:REACT_33795 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Taeniopygia guttata"
xref: Reactome:REACT_34057 "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA, Drosophila melanogaster"
xref: Reactome:REACT_34615 "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA, Dictyostelium discoideum"
xref: Reactome:REACT_34665 "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA, Caenorhabditis elegans"
xref: Reactome:REACT_386 "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA, Homo sapiens"
xref: Reactome:REACT_440 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Homo sapiens"
xref: Reactome:REACT_45972 "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA, Bos taurus"
xref: Reactome:REACT_52162 "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA, Bos taurus"
xref: Reactome:REACT_583 "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA, Homo sapiens"
xref: Reactome:REACT_64 "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA, Homo sapiens"
xref: Reactome:REACT_65800 "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA, Dictyostelium discoideum"
xref: Reactome:REACT_77114 "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA, Rattus norvegicus"
xref: Reactome:REACT_77283 "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA, Danio rerio"
xref: Reactome:REACT_78294 "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA, Xenopus tropicalis"
xref: Reactome:REACT_78515 "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA, Rattus norvegicus"
xref: Reactome:REACT_78642 "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA, Bos taurus"
xref: Reactome:REACT_79462 "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA, Taeniopygia guttata"
xref: Reactome:REACT_79591 "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA, Danio rerio"
xref: Reactome:REACT_80706 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Rattus norvegicus"
xref: Reactome:REACT_80753 "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA, Drosophila melanogaster"
xref: Reactome:REACT_81483 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Mus musculus"
xref: Reactome:REACT_82337 "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA, Mus musculus"
xref: Reactome:REACT_82344 "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA, Canis familiaris"
xref: Reactome:REACT_83439 "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA, Canis familiaris"
xref: Reactome:REACT_83846 "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA, Sus scrofa"
xref: Reactome:REACT_84610 "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA, Taeniopygia guttata"
xref: Reactome:REACT_86074 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Taeniopygia guttata"
xref: Reactome:REACT_86077 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Gallus gallus"
xref: Reactome:REACT_86167 "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA, Mus musculus"
xref: Reactome:REACT_86330 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Mus musculus"
xref: Reactome:REACT_86441 "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA, Taeniopygia guttata"
xref: Reactome:REACT_86568 "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA, Mus musculus"
xref: Reactome:REACT_87 "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA, Homo sapiens"
xref: Reactome:REACT_87006 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Bos taurus"
xref: Reactome:REACT_87419 "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA, Sus scrofa"
xref: Reactome:REACT_87516 "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA, Sus scrofa"
xref: Reactome:REACT_87919 "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA, Xenopus tropicalis"
xref: Reactome:REACT_88425 "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA, Dictyostelium discoideum"
xref: Reactome:REACT_88762 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Mycobacterium tuberculosis"
xref: Reactome:REACT_89046 "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA, Mycobacterium tuberculosis"
xref: Reactome:REACT_89107 "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA, Rattus norvegicus"
xref: Reactome:REACT_89468 "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA, Mus musculus"
xref: Reactome:REACT_90188 "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA, Mycobacterium tuberculosis"
xref: Reactome:REACT_90658 "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA, Caenorhabditis elegans"
xref: Reactome:REACT_90749 "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA, Xenopus tropicalis"
xref: Reactome:REACT_91036 "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA, Mycobacterium tuberculosis"
xref: Reactome:REACT_91290 "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA, Sus scrofa"
xref: Reactome:REACT_91308 "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA, Gallus gallus"
xref: Reactome:REACT_92305 "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA, Danio rerio"
xref: Reactome:REACT_92484 "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA, Escherichia coli"
xref: Reactome:REACT_92535 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Xenopus tropicalis"
xref: Reactome:REACT_92611 "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA, Sus scrofa"
xref: Reactome:REACT_92945 "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA, Bos taurus"
xref: Reactome:REACT_93500 "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA, Bos taurus"
xref: Reactome:REACT_93874 "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA, Caenorhabditis elegans"
xref: Reactome:REACT_94005 "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA, Bos taurus"
xref: Reactome:REACT_94035 "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA, Dictyostelium discoideum"
xref: Reactome:REACT_94076 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Mycobacterium tuberculosis"
xref: Reactome:REACT_94548 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Gallus gallus"
xref: Reactome:REACT_95213 "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA, Caenorhabditis elegans"
xref: Reactome:REACT_95378 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Xenopus tropicalis"
xref: Reactome:REACT_95590 "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA, Rattus norvegicus"
xref: Reactome:REACT_95627 "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA, Danio rerio"
xref: Reactome:REACT_95883 "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA, Mycobacterium tuberculosis"
xref: Reactome:REACT_97155 "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA, Taeniopygia guttata"
xref: Reactome:REACT_97360 "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA, Mus musculus"
xref: Reactome:REACT_97546 "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA, Mus musculus"
xref: Reactome:REACT_97757 "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA, Dictyostelium discoideum"
xref: Reactome:REACT_98369 "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA, Mycobacterium tuberculosis"
xref: Reactome:REACT_99625 "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA, Mus musculus"
xref: Reactome:REACT_99776 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Bos taurus"
xref: Reactome:REACT_99997 "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA, Sus scrofa"
xref: RHEA:16108
xref: UM-BBD_enzymeID:e0014
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0004301
name: epoxide hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: an epoxide + H2O = a glycol." [EC:3.3.2.10]
subset: goslim_chembl
subset: gosubset_prok
synonym: "arene-oxide hydratase activity" BROAD [EC:3.3.2.10]
synonym: "aryl epoxide hydrase activity" BROAD [EC:3.3.2.10]
synonym: "cytosolic epoxide hydrolase activity" EXACT [EC:3.3.2.10]
synonym: "epoxide hydrase activity" BROAD [EC:3.3.2.10]
synonym: "epoxide hydratase activity" BROAD [EC:3.3.2.10]
synonym: "sEH" RELATED [EC:3.3.2.10]
synonym: "soluble epoxide hydrolase activity" NARROW [EC:3.3.2.10]
synonym: "trans-stilbene oxide hydrolase activity" EXACT [EC:3.3.2.10]
xref: EC:3.3.2.10
xref: MetaCyc:3.3.2.10-RXN
xref: UM-BBD_enzymeID:e0397
is_a: GO:0016803 ! ether hydrolase activity

[Term]
id: GO:0004303
name: estradiol 17-beta-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+." [EC:1.1.1.62]
synonym: "17-beta-estradiol dehydrogenase activity" EXACT [EC:1.1.1.62]
synonym: "17-beta-HSD activity" BROAD [EC:1.1.1.62]
synonym: "17-beta-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.62]
synonym: "17beta,20alpha-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.62]
synonym: "17beta-estradiol dehydrogenase activity" EXACT [EC:1.1.1.62]
synonym: "17beta-HSD" RELATED [EC:1.1.1.62]
synonym: "17beta-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.62]
synonym: "20alpha-hydroxysteroid dehydrogenase" BROAD [EC:1.1.1.62]
synonym: "estradiol 17beta-dehydrogenase activity" EXACT [EC:1.1.1.62]
synonym: "estradiol dehydrogenase activity" EXACT [EC:1.1.1.62]
synonym: "estradiol-17beta:NAD(P)+ 17-oxidoreductase activity" EXACT [EC:1.1.1.62]
synonym: "estrogen 17-oxidoreductase activity" EXACT [EC:1.1.1.62]
xref: EC:1.1.1.62
xref: MetaCyc:ESTRADIOL-17-BETA-DEHYDROGENASE-RXN
xref: Reactome:REACT_25243 "Estrone is hydrogenated to estradiol, Homo sapiens"
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004304
name: estrone sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate." [EC:2.8.2.4]
synonym: "3'-phosphoadenylyl sulfate-estrone 3-sulfotransferase activity" EXACT [EC:2.8.2.4]
synonym: "3'-phosphoadenylyl-sulfate:estrone 3-sulfotransferase activity" EXACT [EC:2.8.2.4]
synonym: "3'-phosphoadenylylsulfate:oestrone sulfotransferase activity" EXACT [EC:2.8.2.4]
synonym: "estrogen sulfotransferase" BROAD [EC:2.8.2.4]
synonym: "estrogen sulphotransferase activity" EXACT [EC:2.8.2.4]
synonym: "estrone sulphotransferase activity" EXACT []
synonym: "oestrogen sulphotransferase activity" EXACT [EC:2.8.2.4]
xref: EC:2.8.2.4
xref: MetaCyc:ESTRONE-SULFOTRANSFERASE-RXN
xref: Reactome:REACT_101309 "estrone + PAPS => estrone 3-sulfate + PAP, Mus musculus"
xref: Reactome:REACT_102402 "estrone + PAPS => estrone 3-sulfate + PAP, Canis familiaris"
xref: Reactome:REACT_110189 "estrone + PAPS => estrone 3-sulfate + PAP, Rattus norvegicus"
xref: Reactome:REACT_113027 "estrone + PAPS => estrone 3-sulfate + PAP, Gallus gallus"
xref: Reactome:REACT_28523 "estrone + PAPS => estrone 3-sulfate + PAP, Danio rerio"
xref: Reactome:REACT_28969 "estrone + PAPS => estrone 3-sulfate + PAP, Taeniopygia guttata"
xref: Reactome:REACT_6874 "estrone + PAPS => estrone 3-sulfate + PAP, Homo sapiens"
xref: Reactome:REACT_80747 "estrone + PAPS => estrone 3-sulfate + PAP, Bos taurus"
xref: Reactome:REACT_92523 "estrone + PAPS => estrone 3-sulfate + PAP, Xenopus tropicalis"
xref: RHEA:15976
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0004305
name: ethanolamine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + ethanolamine = ADP + 2 H(+) + phosphoethanolamine." [EC:2.7.1.82, RHEA:13072]
synonym: "ATP:ethanolamine O-phosphotransferase activity" EXACT [EC:2.7.1.82]
synonym: "ethanolamine kinase (phosphorylating)" EXACT [EC:2.7.1.82]
synonym: "ethanolamine phosphokinase activity" EXACT [EC:2.7.1.82]
xref: EC:2.7.1.82
xref: KEGG:R01468
xref: MetaCyc:ETHANOLAMINE-KINASE-RXN
xref: RHEA:13072
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0004306
name: ethanolamine-phosphate cytidylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine." [EC:2.7.7.14]
synonym: "CTP-phosphoethanolamine cytidylyltransferase activity" EXACT [EC:2.7.7.14]
synonym: "CTP:ethanolamine-phosphate cytidylyltransferase activity" EXACT []
synonym: "CTP:phosphoethanolamine cytidylyltransferase activity" EXACT [EC:2.7.7.14]
synonym: "ET" RELATED [EC:2.7.7.14]
synonym: "ethanolamine phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.14]
synonym: "phosphoethanolamine cytidylyltransferase activity" EXACT []
synonym: "phosphorylethanolamine transferase activity" BROAD [EC:2.7.7.14]
xref: EC:2.7.7.14
xref: MetaCyc:2.7.7.14-RXN
xref: RHEA:24595
is_a: GO:0070567 ! cytidylyltransferase activity

[Term]
id: GO:0004307
name: ethanolaminephosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CDP-ethanolamine + 1,2-diacylglycerol = CMP + a phosphatidylethanolamine." [EC:2.7.8.1]
synonym: "CDP-ethanolamine:1,2-diacylglycerol ethanolaminephosphotransferase activity" EXACT [EC:2.7.8.1]
synonym: "CDPethanolamine diglyceride phosphotransferase activity" EXACT [EC:2.7.8.1]
synonym: "diacylglycerol ethanolaminephosphotransferase activity" EXACT [EC:2.7.8.1]
synonym: "EPT" RELATED [EC:2.7.8.1]
synonym: "phosphorylethanolamine-glyceride transferase activity" EXACT [EC:2.7.8.1]
xref: EC:2.7.8.1
xref: MetaCyc:ETHANOLAMINEPHOSPHOTRANSFERASE-RXN
xref: RHEA:14596
is_a: GO:0017169 ! CDP-alcohol phosphatidyltransferase activity

[Term]
id: GO:0004308
name: exo-alpha-sialidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates." [EC:3.2.1.18]
subset: gosubset_prok
synonym: "acetylneuraminidase activity" EXACT [EC:3.2.1.18]
synonym: "acetylneuraminyl hydrolase activity" EXACT [EC:3.2.1.18]
synonym: "alpha-neuraminidase activity" EXACT [EC:3.2.1.18]
synonym: "N-acylneuraminate glycohydrolase activity" EXACT [EC:3.2.1.18]
synonym: "neuraminidase activity" EXACT [EC:3.2.1.18]
synonym: "sialidase activity" EXACT [EC:3.2.1.18]
xref: EC:3.2.1.18
xref: MetaCyc:3.2.1.18-RXN
xref: Reactome:REACT_115699 "Neu5Ac is cleaved from GM3 by NEU3 to form globoside (plasma membrane), Homo sapiens"
xref: Reactome:REACT_115906 "Neu5Ac is cleaved from GM3 by NEU2 to form a globoside (cytosol), Homo sapiens"
xref: Reactome:REACT_116118 "Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen), Homo sapiens"
xref: Reactome:REACT_6348 "Neuraminidase enzymatic release from sialic acid, Homo sapiens"
is_a: GO:0016997 ! alpha-sialidase activity

[Term]
id: GO:0004309
name: exopolyphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: polyphosphate(n) + H2O = polyphosphate(n-1) + phosphate." [EC:3.6.1.11]
subset: gosubset_prok
synonym: "acid phosphoanhydride phosphohydrolase activity" EXACT [EC:3.6.1.11]
synonym: "exopolypase activity" EXACT [EC:3.6.1.11]
synonym: "Gra-Pase activity" EXACT [EC:3.6.1.11]
synonym: "metaphosphatase activity" BROAD [EC:3.6.1.11]
synonym: "polyphosphate phosphohydrolase activity" EXACT [EC:3.6.1.11]
xref: EC:3.6.1.11
xref: MetaCyc:EXOPOLYPHOSPHATASE-RXN
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0004310
name: farnesyl-diphosphate farnesyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 farnesyl diphosphate = diphosphate + presqualene diphosphate." [EC:2.5.1.21]
comment: Note that the two reactions performed by EC:2.5.1.21 are represented in GO by 'farnesyl-diphosphate farnesyltransferase activity ; GO:0004310' and 'squalene synthase activity ; GO:0051996'.
subset: gosubset_prok
synonym: "farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase activity" EXACT [EC:2.5.1.21]
synonym: "presqualene synthase activity" EXACT [EC:2.5.1.21]
synonym: "presqualene-diphosphate synthase activity" EXACT [EC:2.5.1.21]
xref: EC:2.5.1.21
xref: MetaCyc:2.5.1.21-RXN
xref: Reactome:REACT_101662 "Two FPP molecules dimerize to form presqualene diphosphate, Canis familiaris"
xref: Reactome:REACT_105154 "Two FPP molecules dimerize to form presqualene diphosphate, Danio rerio"
xref: Reactome:REACT_106161 "Reduction of presqualene diphosphate to form squalene, Danio rerio"
xref: Reactome:REACT_107400 "Two FPP molecules dimerize to form presqualene diphosphate, Oryza sativa"
xref: Reactome:REACT_108729 "Reduction of presqualene diphosphate to form squalene, Canis familiaris"
xref: Reactome:REACT_108746 "Reduction of presqualene diphosphate to form squalene, Mus musculus"
xref: Reactome:REACT_110869 "Reduction of presqualene diphosphate to form squalene, Oryza sativa"
xref: Reactome:REACT_112589 "Two FPP molecules dimerize to form presqualene diphosphate, Xenopus tropicalis"
xref: Reactome:REACT_112901 "Reduction of presqualene diphosphate to form squalene, Xenopus tropicalis"
xref: Reactome:REACT_29867 "Reduction of presqualene diphosphate to form squalene, Bos taurus"
xref: Reactome:REACT_77262 "Two FPP molecules dimerize to form presqualene diphosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_79816 "Reduction of presqualene diphosphate to form squalene, Gallus gallus"
xref: Reactome:REACT_80102 "Two FPP molecules dimerize to form presqualene diphosphate, Arabidopsis thaliana"
xref: Reactome:REACT_80447 "Reduction of presqualene diphosphate to form squalene, Rattus norvegicus"
xref: Reactome:REACT_80862 "Reduction of presqualene diphosphate to form squalene, Arabidopsis thaliana"
xref: Reactome:REACT_86856 "Two FPP molecules dimerize to form presqualene diphosphate, Mus musculus"
xref: Reactome:REACT_87065 "Reduction of presqualene diphosphate to form squalene, Dictyostelium discoideum"
xref: Reactome:REACT_89846 "Two FPP molecules dimerize to form presqualene diphosphate, Rattus norvegicus"
xref: Reactome:REACT_91748 "Two FPP molecules dimerize to form presqualene diphosphate, Bos taurus"
xref: Reactome:REACT_93117 "Two FPP molecules dimerize to form presqualene diphosphate, Dictyostelium discoideum"
xref: Reactome:REACT_93181 "Two FPP molecules dimerize to form presqualene diphosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_93268 "Two FPP molecules dimerize to form presqualene diphosphate, Taeniopygia guttata"
xref: Reactome:REACT_9504 "Reduction of presqualene diphosphate to form squalene, Homo sapiens"
xref: Reactome:REACT_9512 "Two FPP molecules dimerize to form presqualene diphosphate, Homo sapiens"
xref: Reactome:REACT_95255 "Reduction of presqualene diphosphate to form squalene, Schizosaccharomyces pombe"
xref: Reactome:REACT_96060 "Reduction of presqualene diphosphate to form squalene, Saccharomyces cerevisiae"
xref: Reactome:REACT_98548 "Reduction of presqualene diphosphate to form squalene, Taeniopygia guttata"
xref: Reactome:REACT_99523 "Two FPP molecules dimerize to form presqualene diphosphate, Gallus gallus"
is_a: GO:0004311 ! farnesyltranstransferase activity

[Term]
id: GO:0004311
name: farnesyltranstransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate." [EC:2.5.1.29, RHEA:17656]
comment: The catalyzed reaction forms (free) geranylgeranyl diphosphate.  There is no relationship between this activity and protein farnesyltransferase activity, GO:0004660, where the catalyzed reaction transfers a farnesyl group from farnesyl diphosphate to a target protein.
subset: gosubset_prok
synonym: "farnesyltransferase activity" BROAD [EC:2.5.1.29]
synonym: "geranylgeranyl pyrophosphate synthase activity" EXACT [EC:2.5.1.29]
synonym: "geranylgeranyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.29]
synonym: "geranylgeranyl-diphosphate synthase activity" EXACT [EC:2.5.1.29]
synonym: "geranylgeranyl-PP synthetase activity" EXACT [EC:2.5.1.29]
synonym: "trans,trans-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase activity" EXACT [EC:2.5.1.29]
xref: EC:2.5.1.29
xref: KEGG:R02061
xref: MetaCyc:FARNESYLTRANSTRANSFERASE-RXN
xref: RHEA:17656
is_a: GO:0004659 ! prenyltransferase activity

[Term]
id: GO:0004312
name: fatty acid synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+." [EC:2.3.1.85]
subset: gosubset_prok
synonym: "acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing)" EXACT [EC:2.3.1.85]
synonym: "fatty-acid synthase activity" EXACT []
xref: EC:2.3.1.85
xref: MetaCyc:FATTY-ACID-SYNTHASE-RXN
xref: Reactome:REACT_112198 "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O, Mycobacterium tuberculosis"
xref: Reactome:REACT_113128 "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O, Dictyostelium discoideum"
xref: Reactome:REACT_1497 "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O, Homo sapiens"
xref: Reactome:REACT_28371 "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O, Danio rerio"
xref: Reactome:REACT_78047 "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O, Xenopus tropicalis"
xref: Reactome:REACT_81687 "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O, Mus musculus"
xref: Reactome:REACT_81811 "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O, Drosophila melanogaster"
xref: Reactome:REACT_83657 "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O, Gallus gallus"
xref: Reactome:REACT_83733 "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O, Canis familiaris"
xref: Reactome:REACT_91445 "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O, Taeniopygia guttata"
xref: Reactome:REACT_96308 "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O, Bos taurus"
xref: Reactome:REACT_97636 "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O, Caenorhabditis elegans"
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0004313
name: [acyl-carrier-protein] S-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + [acyl-carrier protein] = CoA + acetyl-[acyl-carrier protein]." [EC:2.3.1.38]
synonym: "[acyl-carrier protein] S-acetyltransferase activity" EXACT []
synonym: "ACAT activity" BROAD [EC:2.3.1.38]
synonym: "acetyl coenzyme A-acyl-carrier-protein transacylase activity" EXACT [EC:2.3.1.38]
synonym: "acetyl-CoA:acyl-carrier-protein S-acetyltransferase activity" EXACT [EC:2.3.1.38]
synonym: "ACP acetyltransferase activity" EXACT [EC:2.3.1.38]
synonym: "ACP S-acetyltransferase activity" EXACT []
synonym: "ACPacetyltransferase activity" EXACT [EC:2.3.1.38]
synonym: "acyl-carrier-protein acetyltransferase activity" EXACT [EC:2.3.1.38]
synonym: "acyl-carrier-protein S-acetyltransferase activity" EXACT [EC:2.3.1.38]
synonym: "acyl-carrier-proteinacetyltransferase activity" EXACT [EC:2.3.1.38]
xref: EC:2.3.1.38
xref: MetaCyc:ACP-S-ACETYLTRANSFER-RXN
is_a: GO:0004312 ! fatty acid synthase activity
is_a: GO:0016418 ! S-acetyltransferase activity

[Term]
id: GO:0004314
name: [acyl-carrier-protein] S-malonyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: malonyl-CoA + [acyl-carrier protein] = CoA + malonyl-[acyl-carrier protein]." [EC:2.3.1.39]
subset: gosubset_prok
synonym: "[acyl-carrier protein] S-malonyltransferase activity" EXACT []
synonym: "ACP S-malonyltransferase activity" EXACT []
synonym: "acyl carrier protein malonyltransferase activity" EXACT [EC:2.3.1.39]
synonym: "acyl carrier proteinmalonyltransferase activity" EXACT [EC:2.3.1.39]
synonym: "acyl-carrier-protein S-malonyltransferase activity" EXACT [EC:2.3.1.39]
synonym: "FabD" RELATED [EC:2.3.1.39]
synonym: "malonyl coenzyme A-acyl carrier protein transacylase activity" EXACT [EC:2.3.1.39]
synonym: "malonyl transacylase activity" BROAD [EC:2.3.1.39]
synonym: "malonyl transferase activity" BROAD [EC:2.3.1.39]
synonym: "malonyl-CoA-acyl carrier protein transacylase activity" EXACT [EC:2.3.1.39]
synonym: "malonyl-CoA:ACP transacylase activity" EXACT [EC:2.3.1.39]
synonym: "malonyl-CoA:AcpM transacylase activity" EXACT [EC:2.3.1.39]
synonym: "malonyl-CoA:acyl carrier protein transacylase activity" EXACT [EC:2.3.1.39]
synonym: "malonyl-CoA:acyl-carrier-protein S-malonyltransferase activity" EXACT [EC:2.3.1.39]
synonym: "MAT" RELATED [EC:2.3.1.39]
synonym: "MCAT activity" EXACT [EC:2.3.1.39]
xref: EC:2.3.1.39
xref: MetaCyc:MALONYL-COA-ACP-TRANSACYL-RXN
is_a: GO:0004312 ! fatty acid synthase activity
is_a: GO:0016419 ! S-malonyltransferase activity

[Term]
id: GO:0004315
name: 3-oxoacyl-[acyl-carrier-protein] synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]." [EC:2.3.1.41]
subset: gosubset_prok
synonym: "3-ketoacyl-acyl carrier protein synthase activity" EXACT [EC:2.3.1.41]
synonym: "3-oxoacyl-[acyl-carrier protein] synthase activity" EXACT []
synonym: "3-oxoacyl-ACP synthase activity" EXACT []
synonym: "3-oxoacyl-acyl-carrier-protein synthase activity" EXACT [EC:2.3.1.41]
synonym: "3-oxoacyl:ACP synthase I" RELATED [EC:2.3.1.41]
synonym: "acyl-acyl-carrier-protein:malonyl-acyl-carrier-protein C-acyltransferase (decarboxylating)" EXACT [EC:2.3.1.41]
synonym: "acyl-malonyl acyl carrier protein-condensing enzyme activity" EXACT [EC:2.3.1.41]
synonym: "acyl-malonyl(acyl-carrier-protein)-condensing enzyme activity" EXACT [EC:2.3.1.41]
synonym: "beta-ketoacyl acyl carrier protein synthase activity" EXACT [EC:2.3.1.41]
synonym: "beta-ketoacyl synthetase activity" EXACT [EC:2.3.1.41]
synonym: "beta-ketoacyl-[acyl carrier protein] synthase activity" EXACT [EC:2.3.1.41]
synonym: "beta-ketoacyl-ACP synthase I activity" EXACT [EC:2.3.1.41]
synonym: "beta-ketoacyl-ACP synthetase activity" EXACT [EC:2.3.1.41]
synonym: "beta-ketoacyl-acyl carrier protein synthase activity" EXACT [EC:2.3.1.41]
synonym: "beta-ketoacyl-acyl carrier protein synthetase activity" EXACT [EC:2.3.1.41]
synonym: "beta-ketoacyl-acyl-carrier-protein synthase I" RELATED [EC:2.3.1.41]
synonym: "beta-ketoacylsynthase activity" EXACT [EC:2.3.1.41]
synonym: "condensing enzyme activity" BROAD [EC:2.3.1.41]
synonym: "FabB" RELATED [EC:2.3.1.41]
synonym: "FabF1" RELATED [EC:2.3.1.41]
synonym: "fatty acid condensing enzyme activity" BROAD [EC:2.3.1.41]
synonym: "KAS I activity" NARROW [EC:2.3.1.41]
synonym: "KASI" RELATED [EC:2.3.1.41]
synonym: "ketoacyl-ACP synthase activity" EXACT []
xref: EC:2.3.1.41
xref: MetaCyc:3-OXOACYL-ACP-SYNTH-RXN
is_a: GO:0004312 ! fatty acid synthase activity

[Term]
id: GO:0004316
name: 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+." [EC:1.1.1.100]
subset: gosubset_prok
synonym: "(3R)-3-hydroxyacyl-acyl-carrier-protein:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.100]
synonym: "3-ketoacyl acyl carrier protein reductase activity" EXACT [EC:1.1.1.100]
synonym: "3-oxoacyl-[acyl-carrier protein] reductase activity" EXACT []
synonym: "3-oxoacyl-ACP reductase activity" EXACT []
synonym: "3-oxoacyl-ACPreductase activity" EXACT [EC:1.1.1.100]
synonym: "3-oxoacyl-acyl-carrier-protein reductase activity" EXACT [EC:1.1.1.100]
synonym: "beta-ketoacyl acyl carrier protein (ACP) reductase activity" EXACT [EC:1.1.1.100]
synonym: "beta-ketoacyl reductase activity" EXACT [EC:1.1.1.100]
synonym: "beta-ketoacyl thioester reductase activity" EXACT [EC:1.1.1.100]
synonym: "beta-ketoacyl-ACP reductase activity" EXACT [EC:1.1.1.100]
synonym: "beta-ketoacyl-acyl carrier protein reductase activity" EXACT [EC:1.1.1.100]
synonym: "beta-ketoacyl-acyl-carrier protein(ACP) reductase activity" EXACT [EC:1.1.1.100]
synonym: "NADPH-specific 3-oxoacyl-acylcarrier proteinreductase activity" EXACT [EC:1.1.1.100]
xref: EC:1.1.1.100
xref: MetaCyc:3-OXOACYL-ACP-REDUCT-RXN
is_a: GO:0004312 ! fatty acid synthase activity
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004317
name: 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3R)-3-hydroxypalmitoyl-[acyl-carrier protein] = 2-hexadecenoyl-[acyl-carrier protein] + H2O." [EC:4.2.1.61]
synonym: "(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] hydro-lyase activity" EXACT [EC:4.2.1.61]
synonym: "(3R)-3-hydroxypalmitoyl-acyl-carrier-protein hydro-lyase (hexadec-2-enoyl-acyl-carrier protein-forming)" EXACT [EC:4.2.1.61]
synonym: "(3R)-3-hydroxypalmitoyl-acyl-carrier-protein hydro-lyase activity" EXACT [EC:4.2.1.61]
synonym: "3-hydroxypalmitoyl-[acyl-carrier protein] dehydratase activity" EXACT []
synonym: "3-hydroxypalmitoyl-ACP dehydratase activity" EXACT []
synonym: "3-hydroxypalmitoyl-acyl-carrier-protein dehydratase activity" EXACT [EC:4.2.1.61]
synonym: "beta-hydroxypalmitoyl thioester dehydratase activity" EXACT [EC:4.2.1.61]
synonym: "beta-hydroxypalmitoyl-acyl carrier protein dehydrase activity" EXACT [EC:4.2.1.61]
synonym: "beta-hydroxypalmityl-ACP dehydrase activity" EXACT [EC:4.2.1.61]
synonym: "D-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity" EXACT [EC:4.2.1.61]
synonym: "D-3-hydroxypalmitoyl-acyl-carrier-protein dehydratase activity" EXACT [EC:4.2.1.61]
xref: EC:4.2.1.61
xref: KEGG:R04462
xref: MetaCyc:4.2.1.61-RXN
is_a: GO:0004312 ! fatty acid synthase activity
is_a: GO:0019171 ! 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity

[Term]
id: GO:0004318
name: enoyl-[acyl-carrier-protein] reductase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + NAD+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+." [EC:1.3.1.9]
subset: gosubset_prok
synonym: "acyl-acyl-carrier-protein:NAD+ oxidoreductase" EXACT [EC:1.3.1.9]
synonym: "enoyl-[acyl-carrier protein] reductase (NADH) activity" EXACT [EC:1.3.1.9]
synonym: "enoyl-ACP reductase (NADH) activity" EXACT [EC:1.3.1.9]
synonym: "enoyl-acyl-carrier-protein reductase (NADH)" EXACT [EC:1.3.1.9]
synonym: "NADH-enoyl acyl carrier protein reductase activity" EXACT [EC:1.3.1.9]
synonym: "NADH-specific enoyl-ACP reductase activity" EXACT [EC:1.3.1.9]
xref: EC:1.3.1.9
xref: MetaCyc:ENOYL-ACP-REDUCT-NADH-RXN
is_a: GO:0004312 ! fatty acid synthase activity
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004319
name: enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + NADP+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+." [EC:1.3.1.10]
subset: gosubset_prok
synonym: "acyl-acyl-carrier-protein:NADP+ oxidoreductase (B-specific)" EXACT [EC:1.3.1.10]
synonym: "enoyl acyl-carrier-protein reductase activity" EXACT [EC:1.3.1.10]
synonym: "enoyl-[acyl-carrier protein] reductase (NADPH, B-specific) activity" EXACT []
synonym: "enoyl-ACP reductase (NADPH, B-specific) activity" EXACT []
synonym: "enoyl-acyl-carrier-protein reductase (NADPH, B-specific)" EXACT [EC:1.3.1.10]
synonym: "enoyl-acyl-carrier-protein reductase (NADPH2, B-specific)" EXACT [EC:1.3.1.10]
synonym: "NADPH 2-enoyl Co A reductase activity" EXACT [EC:1.3.1.10]
synonym: "reductase, enoyl-acyl carrier protein (reduced nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.3.1.10]
xref: EC:1.3.1.10
xref: MetaCyc:ENOYL-ACP-REDUCT-NADPH-RXN
is_a: GO:0004312 ! fatty acid synthase activity
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004320
name: oleoyl-[acyl-carrier-protein] hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: oleoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + oleate." [EC:3.1.2.14]
subset: gosubset_prok
synonym: "oleoyl-[acyl-carrier protein] hydrolase activity" EXACT []
synonym: "oleoyl-ACP hydrolase activity" EXACT []
synonym: "oleoyl-ACP thioesterase activity" EXACT [EC:3.1.2.14]
synonym: "oleoyl-acyl carrier protein thioesterase activity" EXACT [EC:3.1.2.14]
synonym: "oleoyl-acyl-carrier-protein hydrolase" BROAD [EC:3.1.2.14]
xref: EC:3.1.2.14
xref: MetaCyc:3.1.2.14-RXN
xref: MetaCyc:PWY-5142
is_a: GO:0016297 ! acyl-[acyl-carrier-protein] hydrolase activity

[Term]
id: GO:0004321
name: fatty-acyl-CoA synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = a long-chain acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+." [EC:2.3.1.86]
synonym: "acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl- reducing)" EXACT [EC:2.3.1.86]
synonym: "fatty acyl CoA synthase activity" EXACT [GOC:curators]
synonym: "yeast fatty acid synthase activity" NARROW [EC:2.3.1.86]
xref: EC:2.3.1.86
xref: MetaCyc:FATTY-ACYL-COA-SYNTHASE-RXN
is_a: GO:0016408 ! C-acyltransferase activity

[Term]
id: GO:0004322
name: ferroxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O." [EC:1.16.3.1]
subset: gosubset_prok
synonym: "caeruloplasmin" RELATED [EC:1.16.3.1]
synonym: "ceruloplasmin activity" NARROW [EC:1.16.3.1]
synonym: "Fe(II):oxygen oxidoreductase activity" EXACT [EC:1.16.3.1]
synonym: "ferro:O2 oxidoreductase activity" EXACT [EC:1.16.3.1]
synonym: "ferroxidase I" RELATED [EC:1.16.3.1]
synonym: "ferroxidase, iron II:oxygen oxidoreductase activity" EXACT [EC:1.16.3.1]
synonym: "iron(II): oxygen oxidoreductase activity" EXACT [EC:1.16.3.1]
synonym: "multicopper ferroxidase iron transport mediator activity" NARROW []
xref: EC:1.16.3.1
xref: MetaCyc:RXN0-1483
xref: Reactome:REACT_115629 "Ferritin stores iron, Homo sapiens"
xref: Reactome:REACT_25098 "Oxidation of Fe2+ by ceruloplasmin, Homo sapiens"
xref: Reactome:REACT_25198 "Oxidation of Fe2+ by hephaestin, Homo sapiens"
xref: RHEA:11151
is_a: GO:0016724 ! oxidoreductase activity, oxidizing metal ions, oxygen as acceptor

[Term]
id: GO:0004323
name: obsolete multicopper ferroxidase iron transport mediator activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O." [EC:1.16.3.1]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "multicopper ferroxidase iron transport mediator activity" EXACT []
is_obsolete: true
consider: GO:0004322
consider: GO:0005381

[Term]
id: GO:0004324
name: ferredoxin-NADP+ reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: reduced ferredoxin + NADP+ = oxidized ferredoxin + NADPH + H+." [EC:1.18.1.2, GOC:kd]
comment: Note that this term specifically refers to the reaction proceeding in the direction shown; it should therefore be used to annotate gene products that catalyze the oxidation of reduced ferredoxin or adrenodoxin; also consider annotating to the molecular function term 'NADPH-adrenodoxin reductase activity ; GO:0015039'.
subset: gosubset_prok
synonym: "ferredoxin-NADP oxidoreductase activity" EXACT [EC:1.18.1.2]
synonym: "ferredoxin-NADP reductase activity" EXACT []
synonym: "ferredoxin-NADP-oxidoreductase activity" EXACT [EC:1.18.1.2]
synonym: "ferredoxin-nicotinamide adenine dinucleotide phosphate reductase activity" EXACT [EC:1.18.1.2]
synonym: "ferredoxin-nicotinamide-adenine dinucleotide phosphate (oxidized) reductase activity" EXACT [EC:1.18.1.2]
synonym: "ferredoxin-TPN reductase activity" EXACT [EC:1.18.1.2]
synonym: "ferredoxin:NADP+ oxidoreductase activity" EXACT [EC:1.18.1.2]
synonym: "NADP:ferredoxin oxidoreductase activity" EXACT [EC:1.18.1.2]
synonym: "NADPH:ferredoxin oxidoreductase activity" EXACT [EC:1.18.1.2]
synonym: "reduced nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase activity" EXACT [EC:1.18.1.2]
synonym: "TPNH-ferredoxin reductase activity" EXACT [EC:1.18.1.2]
xref: EC:1.18.1.2
xref: MetaCyc:1.18.1.2-RXN
is_a: GO:0016731 ! oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor

[Term]
id: GO:0004325
name: ferrochelatase activity
namespace: molecular_function
def: "Catalysis of the reaction: protoheme = Fe(2+) + protoporphyrin IX." [EC:4.99.1.1, RHEA:22587]
subset: gosubset_prok
synonym: "ferro-protoporphyrin chelatase activity" EXACT [EC:4.99.1.1]
synonym: "heme synthase activity" EXACT [EC:4.99.1.1]
synonym: "heme synthetase activity" EXACT [EC:4.99.1.1]
synonym: "iron chelatase activity" EXACT [EC:4.99.1.1]
synonym: "protoheme ferro-lyase (protoporphyrin-forming)" EXACT [EC:4.99.1.1]
synonym: "protoheme ferro-lyase activity" EXACT [EC:4.99.1.1]
synonym: "protoheme ferrolyase activity" EXACT [EC:4.99.1.1]
xref: EC:4.99.1.1
xref: KEGG:R00310
xref: MetaCyc:PROTOHEMEFERROCHELAT-RXN
xref: Reactome:REACT_102151 "Ferrous iron is inserted into protoporphyrin IX to form heme, Schizosaccharomyces pombe"
xref: Reactome:REACT_103500 "Ferrous iron is inserted into protoporphyrin IX to form heme, Drosophila melanogaster"
xref: Reactome:REACT_113497 "Ferrous iron is inserted into protoporphyrin IX to form heme, Oryza sativa"
xref: Reactome:REACT_115167 "Ferrous iron is inserted into protoporphyrin IX to form heme, Arabidopsis thaliana"
xref: Reactome:REACT_115628 "protoporphyrin IX + Fe++ => heme + 2 H+, Gallus gallus"
xref: Reactome:REACT_31724 "Ferrous iron is inserted into protoporphyrin IX to form heme, Mus musculus"
xref: Reactome:REACT_34447 "Ferrous iron is inserted into protoporphyrin IX to form heme, Mycobacterium tuberculosis"
xref: Reactome:REACT_52193 "Ferrous iron is inserted into protoporphyrin IX to form heme, Plasmodium falciparum"
xref: Reactome:REACT_77614 "Ferrous iron is inserted into protoporphyrin IX to form heme, Xenopus tropicalis"
xref: Reactome:REACT_78000 "Ferrous iron is inserted into protoporphyrin IX to form heme, Dictyostelium discoideum"
xref: Reactome:REACT_78120 "Ferrous iron is inserted into protoporphyrin IX to form heme, Canis familiaris"
xref: Reactome:REACT_80925 "Ferrous iron is inserted into protoporphyrin IX to form heme, Rattus norvegicus"
xref: Reactome:REACT_83976 "Ferrous iron is inserted into protoporphyrin IX to form heme, Sus scrofa"
xref: Reactome:REACT_87767 "Ferrous iron is inserted into protoporphyrin IX to form heme, Escherichia coli"
xref: Reactome:REACT_90534 "Ferrous iron is inserted into protoporphyrin IX to form heme, Danio rerio"
xref: Reactome:REACT_92687 "Ferrous iron is inserted into protoporphyrin IX to form heme, Gallus gallus"
xref: Reactome:REACT_93298 "Ferrous iron is inserted into protoporphyrin IX to form heme, Staphylococcus aureus N315"
xref: Reactome:REACT_9461 "Ferrous iron is inserted into protoporphyrin IX to form heme, Homo sapiens"
xref: Reactome:REACT_96094 "Ferrous iron is inserted into protoporphyrin IX to form heme, Saccharomyces cerevisiae"
xref: Reactome:REACT_96730 "Ferrous iron is inserted into protoporphyrin IX to form heme, Taeniopygia guttata"
xref: Reactome:REACT_97060 "Ferrous iron is inserted into protoporphyrin IX to form heme, Bos taurus"
xref: RHEA:22587
is_a: GO:0016829 ! lyase activity

[Term]
id: GO:0004326
name: tetrahydrofolylpolyglutamate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1)." [EC:6.3.2.17]
subset: gosubset_prok
synonym: "folate polyglutamate synthetase activity" EXACT [EC:6.3.2.17]
synonym: "folylpoly(gamma-glutamate) synthase activity" EXACT [EC:6.3.2.17]
synonym: "folylpoly-gamma-glutamate synthase activity" EXACT [EC:6.3.2.17]
synonym: "folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase activity" EXACT [EC:6.3.2.17]
synonym: "folylpolyglutamate synthase activity" EXACT []
synonym: "folylpolyglutamate synthetase activity" EXACT [EC:6.3.2.17]
synonym: "folylpolyglutamyl synthetase activity" EXACT [EC:6.3.2.17]
synonym: "formyltetrahydropteroyldiglutamate synthetase activity" EXACT [EC:6.3.2.17]
synonym: "FPGS activity" EXACT [EC:6.3.2.17]
synonym: "N(10)-formyltetrahydropteroyldiglutamate synthetase activity" EXACT [EC:6.3.2.17]
synonym: "N10-formyltetrahydropteroyldiglutamate synthetase activity" EXACT [EC:6.3.2.17]
synonym: "tetrahydrofolate synthase activity" EXACT [EC:6.3.2.17]
synonym: "tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming) activity" EXACT [EC:6.3.2.17]
synonym: "tetrahydrofolyl-[gamma-Glu]n:L-glutamate gamma-ligase (ADP-forming)" EXACT [EC:6.3.2.17]
synonym: "tetrahydropteroyl-[gamma-polyglutamate]:L-glutamate gamma-ligase (ADP-forming)" EXACT [EC:6.3.2.17]
xref: EC:6.3.2.17
xref: MetaCyc:FOLYLPOLYGLUTAMATESYNTH-RXN
xref: Reactome:REACT_101002 "Conversion of mitochondrial THF to THF-polyglutamate, Saccharomyces cerevisiae"
xref: Reactome:REACT_101642 "Conversion of mitochondrial THF to THF-polyglutamate, Caenorhabditis elegans"
xref: Reactome:REACT_102351 "Conversion of mitochondrial THF to THF-polyglutamate, Gallus gallus"
xref: Reactome:REACT_102476 "Conversion of cytosolic 5-methyltetrahydrofolate (5-methylTHF) to 5-methylTHF-polyglutamate, Arabidopsis thaliana"
xref: Reactome:REACT_103881 "Conversion of cytosolic 5-methyltetrahydrofolate (5-methylTHF) to 5-methylTHF-polyglutamate, Danio rerio"
xref: Reactome:REACT_103964 "Conversion of mitochondrial THF to THF-polyglutamate, Mus musculus"
xref: Reactome:REACT_104258 "Conversion of mitochondrial THF to THF-polyglutamate, Taeniopygia guttata"
xref: Reactome:REACT_104550 "Conversion of cytosolic THF to THF-polyglutamate, Plasmodium falciparum"
xref: Reactome:REACT_104661 "Conversion of cytosolic THF to THF-polyglutamate, Caenorhabditis elegans"
xref: Reactome:REACT_104755 "Conversion of cytosolic THF to THF-polyglutamate, Canis familiaris"
xref: Reactome:REACT_105205 "Conversion of mitochondrial THF to THF-polyglutamate, Escherichia coli"
xref: Reactome:REACT_107192 "Conversion of cytosolic THF to THF-polyglutamate, Danio rerio"
xref: Reactome:REACT_108051 "Conversion of cytosolic 5-methyltetrahydrofolate (5-methylTHF) to 5-methylTHF-polyglutamate, Oryza sativa"
xref: Reactome:REACT_108617 "Conversion of mitochondrial THF to THF-polyglutamate, Drosophila melanogaster"
xref: Reactome:REACT_109321 "Conversion of cytosolic 5-methyltetrahydrofolate (5-methylTHF) to 5-methylTHF-polyglutamate, Plasmodium falciparum"
xref: Reactome:REACT_109341 "Conversion of cytosolic THF to THF-polyglutamate, Schizosaccharomyces pombe"
xref: Reactome:REACT_109757 "Conversion of cytosolic THF to THF-polyglutamate, Dictyostelium discoideum"
xref: Reactome:REACT_110084 "Conversion of cytosolic 5-methyltetrahydrofolate (5-methylTHF) to 5-methylTHF-polyglutamate, Schizosaccharomyces pombe"
xref: Reactome:REACT_11083 "Conversion of cytosolic THF to THF-polyglutamate, Homo sapiens"
xref: Reactome:REACT_11098 "Conversion of cytosolic 5-methyltetrahydrofolate (5-methylTHF) to 5-methylTHF-polyglutamate, Homo sapiens"
xref: Reactome:REACT_11134 "Conversion of mitochondrial THF to THF-polyglutamate, Homo sapiens"
xref: Reactome:REACT_28245 "Conversion of cytosolic 5-methyltetrahydrofolate (5-methylTHF) to 5-methylTHF-polyglutamate, Bos taurus"
xref: Reactome:REACT_28993 "Conversion of mitochondrial THF to THF-polyglutamate, Danio rerio"
xref: Reactome:REACT_30882 "Conversion of mitochondrial THF to THF-polyglutamate, Dictyostelium discoideum"
xref: Reactome:REACT_31048 "Conversion of mitochondrial THF to THF-polyglutamate, Staphylococcus aureus N315"
xref: Reactome:REACT_31179 "Conversion of cytosolic THF to THF-polyglutamate, Staphylococcus aureus N315"
xref: Reactome:REACT_31465 "Conversion of cytosolic 5-methyltetrahydrofolate (5-methylTHF) to 5-methylTHF-polyglutamate, Gallus gallus"
xref: Reactome:REACT_31897 "Conversion of cytosolic THF to THF-polyglutamate, Gallus gallus"
xref: Reactome:REACT_32176 "Conversion of cytosolic 5-methyltetrahydrofolate (5-methylTHF) to 5-methylTHF-polyglutamate, Xenopus tropicalis"
xref: Reactome:REACT_32353 "Conversion of mitochondrial THF to THF-polyglutamate, Canis familiaris"
xref: Reactome:REACT_32481 "Conversion of cytosolic THF to THF-polyglutamate, Sus scrofa"
xref: Reactome:REACT_33340 "Conversion of mitochondrial THF to THF-polyglutamate, Xenopus tropicalis"
xref: Reactome:REACT_34097 "Conversion of cytosolic 5-methyltetrahydrofolate (5-methylTHF) to 5-methylTHF-polyglutamate, Taeniopygia guttata"
xref: Reactome:REACT_34214 "Conversion of cytosolic THF to THF-polyglutamate, Bos taurus"
xref: Reactome:REACT_34227 "Conversion of cytosolic 5-methyltetrahydrofolate (5-methylTHF) to 5-methylTHF-polyglutamate, Escherichia coli"
xref: Reactome:REACT_34370 "Conversion of mitochondrial THF to THF-polyglutamate, Arabidopsis thaliana"
xref: Reactome:REACT_34481 "Conversion of cytosolic THF to THF-polyglutamate, Arabidopsis thaliana"
xref: Reactome:REACT_77255 "Conversion of cytosolic 5-methyltetrahydrofolate (5-methylTHF) to 5-methylTHF-polyglutamate, Mus musculus"
xref: Reactome:REACT_78566 "Conversion of mitochondrial THF to THF-polyglutamate, Bos taurus"
xref: Reactome:REACT_79142 "Conversion of mitochondrial THF to THF-polyglutamate, Plasmodium falciparum"
xref: Reactome:REACT_79493 "Conversion of cytosolic 5-methyltetrahydrofolate (5-methylTHF) to 5-methylTHF-polyglutamate, Saccharomyces cerevisiae"
xref: Reactome:REACT_82730 "Conversion of mitochondrial THF to THF-polyglutamate, Mycobacterium tuberculosis"
xref: Reactome:REACT_83339 "Conversion of mitochondrial THF to THF-polyglutamate, Sus scrofa"
xref: Reactome:REACT_83909 "Conversion of cytosolic 5-methyltetrahydrofolate (5-methylTHF) to 5-methylTHF-polyglutamate, Canis familiaris"
xref: Reactome:REACT_84744 "Conversion of cytosolic THF to THF-polyglutamate, Taeniopygia guttata"
xref: Reactome:REACT_85520 "Conversion of cytosolic 5-methyltetrahydrofolate (5-methylTHF) to 5-methylTHF-polyglutamate, Drosophila melanogaster"
xref: Reactome:REACT_85664 "Conversion of cytosolic 5-methyltetrahydrofolate (5-methylTHF) to 5-methylTHF-polyglutamate, Mycobacterium tuberculosis"
xref: Reactome:REACT_86615 "Conversion of cytosolic 5-methyltetrahydrofolate (5-methylTHF) to 5-methylTHF-polyglutamate, Sus scrofa"
xref: Reactome:REACT_87310 "Conversion of cytosolic 5-methyltetrahydrofolate (5-methylTHF) to 5-methylTHF-polyglutamate, Dictyostelium discoideum"
xref: Reactome:REACT_88455 "Conversion of cytosolic THF to THF-polyglutamate, Escherichia coli"
xref: Reactome:REACT_88637 "Conversion of cytosolic THF to THF-polyglutamate, Mus musculus"
xref: Reactome:REACT_88916 "Conversion of cytosolic 5-methyltetrahydrofolate (5-methylTHF) to 5-methylTHF-polyglutamate, Staphylococcus aureus N315"
xref: Reactome:REACT_90378 "Conversion of cytosolic THF to THF-polyglutamate, Mycobacterium tuberculosis"
xref: Reactome:REACT_91152 "Conversion of cytosolic THF to THF-polyglutamate, Oryza sativa"
xref: Reactome:REACT_92262 "Conversion of cytosolic THF to THF-polyglutamate, Saccharomyces cerevisiae"
xref: Reactome:REACT_95920 "Conversion of mitochondrial THF to THF-polyglutamate, Schizosaccharomyces pombe"
xref: Reactome:REACT_97118 "Conversion of cytosolic 5-methyltetrahydrofolate (5-methylTHF) to 5-methylTHF-polyglutamate, Caenorhabditis elegans"
xref: Reactome:REACT_97580 "Conversion of cytosolic THF to THF-polyglutamate, Xenopus tropicalis"
xref: Reactome:REACT_97776 "Conversion of mitochondrial THF to THF-polyglutamate, Oryza sativa"
xref: Reactome:REACT_99456 "Conversion of cytosolic THF to THF-polyglutamate, Drosophila melanogaster"
is_a: GO:0016881 ! acid-amino acid ligase activity
relationship: part_of GO:0046901 ! tetrahydrofolylpolyglutamate biosynthetic process

[Term]
id: GO:0004327
name: obsolete formaldehyde dehydrogenase (glutathione) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: formaldehyde + glutathione + NAD+ = S-formylglutathione + NADH + H+." [EC:1.2.1.1]
comment: This term was made obsolete because it was derived from an EC entry (1.2.1.1) that has since been split into two entries.
subset: gosubset_prok
synonym: "formaldehyde dehydrogenase (glutathione) activity" EXACT []
is_obsolete: true
consider: GO:0051903
consider: GO:0051907

[Term]
id: GO:0004328
name: formamidase activity
namespace: molecular_function
alt_id: GO:0034566
def: "Catalysis of the reaction: formamide + H(2)O = formate + NH(4)(+)." [EC:3.5.1.49, RHEA:21951]
subset: gosubset_prok
synonym: "formamide amidohydrolase activity" EXACT [EC:3.5.1.49]
synonym: "formamide hydrolase activity" EXACT []
xref: EC:3.5.1.49
xref: KEGG:R00524
xref: MetaCyc:FORMAMIDASE-RXN
xref: RHEA:21951
xref: UM-BBD_reactionID:r0873
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0004329
name: formate-tetrahydrofolate ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate." [EC:6.3.4.3]
subset: gosubset_prok
synonym: "10-formyl-THF synthetase activity" EXACT [GOC:vw]
synonym: "10-formyltetrahydrofolate synthetase activity" EXACT [EC:6.3.4.3]
synonym: "formate:tetrahydrofolate ligase (ADP-forming)" EXACT [EC:6.3.4.3]
synonym: "formyltetrahydrofolate synthetase activity" EXACT [EC:6.3.4.3]
synonym: "tetrahydrofolate formylase activity" EXACT [EC:6.3.4.3]
synonym: "tetrahydrofolic formylase activity" EXACT [EC:6.3.4.3]
xref: EC:6.3.4.3
xref: MetaCyc:FORMATETHFLIG-RXN
xref: Reactome:REACT_101414 "THF polyglutamate + formate + ATP => 10-formylTHF polyglutamate + ADP + orthophosphate, Drosophila melanogaster"
xref: Reactome:REACT_104328 "THF polyglutamate + formate + ATP => 10-formylTHF polyglutamate + ADP + orthophosphate, Gallus gallus"
xref: Reactome:REACT_109830 "THF polyglutamate + formate + ATP => 10-formylTHF polyglutamate + ADP + orthophosphate, Canis familiaris"
xref: Reactome:REACT_11109 "THF polyglutamate + formate + ATP => 10-formylTHF polyglutamate + ADP + orthophosphate, Homo sapiens"
xref: Reactome:REACT_112991 "THF polyglutamate + formate + ATP => 10-formylTHF polyglutamate + ADP + orthophosphate, Xenopus tropicalis"
xref: Reactome:REACT_34410 "THF polyglutamate + formate + ATP => 10-formylTHF polyglutamate + ADP + orthophosphate, Taeniopygia guttata"
xref: Reactome:REACT_78582 "THF polyglutamate + formate + ATP => 10-formylTHF polyglutamate + ADP + orthophosphate, Mus musculus"
xref: Reactome:REACT_84185 "THF polyglutamate + formate + ATP => 10-formylTHF polyglutamate + ADP + orthophosphate, Sus scrofa"
xref: Reactome:REACT_87843 "THF polyglutamate + formate + ATP => 10-formylTHF polyglutamate + ADP + orthophosphate, Mycobacterium tuberculosis"
xref: Reactome:REACT_89407 "THF polyglutamate + formate + ATP => 10-formylTHF polyglutamate + ADP + orthophosphate, Rattus norvegicus"
xref: Reactome:REACT_89474 "THF polyglutamate + formate + ATP => 10-formylTHF polyglutamate + ADP + orthophosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_91046 "THF polyglutamate + formate + ATP => 10-formylTHF polyglutamate + ADP + orthophosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_97400 "THF polyglutamate + formate + ATP => 10-formylTHF polyglutamate + ADP + orthophosphate, Danio rerio"
xref: Reactome:REACT_98873 "THF polyglutamate + formate + ATP => 10-formylTHF polyglutamate + ADP + orthophosphate, Bos taurus"
xref: RHEA:20224
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0004331
name: fructose-2,6-bisphosphate 2-phosphatase activity
namespace: molecular_function
alt_id: GO:0004330
def: "Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose-6-phosphate + phosphate." [EC:3.1.3.46]
subset: gosubset_prok
synonym: "beta-D-fructose-2,6-bisphosphate 2-phosphohydrolase activity" EXACT [EC:3.1.3.46]
synonym: "D-fructose-2,6-bisphosphate 2-phosphohydrolase activity" EXACT [EC:3.1.3.46]
synonym: "fructose-2,6-bisphosphatase activity" EXACT [EC:3.1.3.46]
xref: EC:3.1.3.46
xref: MetaCyc:3.1.3.46-RXN
xref: Reactome:REACT_102107 "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_103429 "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate, Drosophila melanogaster"
xref: Reactome:REACT_1084 "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate, Homo sapiens"
xref: Reactome:REACT_108509 "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate, Sus scrofa"
xref: Reactome:REACT_109004 "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate, Danio rerio"
xref: Reactome:REACT_113676 "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate, Gallus gallus"
xref: Reactome:REACT_116155 "fructose 2,6-bisphosphate + H2O => fructose 6-phosphate + orthophosphate, Gallus gallus"
xref: Reactome:REACT_28511 "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_30510 "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate, Bos taurus"
xref: Reactome:REACT_31865 "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate, Taeniopygia guttata"
xref: Reactome:REACT_32951 "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate, Canis familiaris"
xref: Reactome:REACT_33560 "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate, Mus musculus"
xref: Reactome:REACT_34794 "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate, Rattus norvegicus"
xref: Reactome:REACT_61251 "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_80450 "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate, Staphylococcus aureus N315"
xref: Reactome:REACT_82116 "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate, Arabidopsis thaliana"
xref: Reactome:REACT_88106 "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate, Oryza sativa"
xref: Reactome:REACT_91852 "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate, Xenopus tropicalis"
xref: RHEA:17292
is_a: GO:0050308 ! sugar-phosphatase activity

[Term]
id: GO:0004332
name: fructose-bisphosphate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde-3-phosphate." [EC:4.1.2.13]
subset: gosubset_prok
synonym: "1,6-diphosphofructose aldolase activity" EXACT [EC:4.1.2.13]
synonym: "aldolase activity" BROAD [EC:4.1.2.13]
synonym: "D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase (glycerone-phosphate-forming)" EXACT [EC:4.1.2.13]
synonym: "D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase activity" EXACT [EC:4.1.2.13]
synonym: "diphosphofructose aldolase activity" EXACT [EC:4.1.2.13]
synonym: "fructoaldolase activity" EXACT [EC:4.1.2.13]
synonym: "fructose 1,6-diphosphate aldolase activity" EXACT [EC:4.1.2.13]
synonym: "fructose 1-monophosphate aldolase activity" EXACT [EC:4.1.2.13]
synonym: "fructose 1-phosphate aldolase activity" EXACT [EC:4.1.2.13]
synonym: "fructose diphosphate aldolase activity" EXACT [EC:4.1.2.13]
synonym: "fructose-1,6-bisphosphate triosephosphate-lyase activity" EXACT [EC:4.1.2.13]
synonym: "ketose 1-phosphate aldolase activity" EXACT [EC:4.1.2.13]
synonym: "phosphofructoaldolase activity" EXACT [EC:4.1.2.13]
synonym: "SMALDO" RELATED [EC:4.1.2.13]
synonym: "zymohexase activity" EXACT [EC:4.1.2.13]
xref: EC:4.1.2.13
xref: MetaCyc:F16ALDOLASE-RXN
xref: Reactome:REACT_100157 "D-fructose 1-phosphate <=> D-glyceraldehyde + dihydroxyacetone phosphate, Drosophila melanogaster"
xref: Reactome:REACT_103150 "dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate, Caenorhabditis elegans"
xref: Reactome:REACT_103723 "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate, Danio rerio"
xref: Reactome:REACT_104551 "D-fructose 1-phosphate <=> D-glyceraldehyde + dihydroxyacetone phosphate, Arabidopsis thaliana"
xref: Reactome:REACT_105453 "D-fructose 1-phosphate <=> D-glyceraldehyde + dihydroxyacetone phosphate, Gallus gallus"
xref: Reactome:REACT_106543 "dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate, Oryza sativa"
xref: Reactome:REACT_109373 "D-fructose 1-phosphate <=> D-glyceraldehyde + dihydroxyacetone phosphate, Sus scrofa"
xref: Reactome:REACT_109674 "dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate, Mus musculus"
xref: Reactome:REACT_115951 "dihydroxyacetone phosphate + glyceraldehyde 3-phosphate <=> fructose 1,6-bisphosphate, Gallus gallus"
xref: Reactome:REACT_116035 "fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + glyceraldehyde 3-phosphate, Gallus gallus"
xref: Reactome:REACT_1602 "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate, Homo sapiens"
xref: Reactome:REACT_2013 "D-fructose 1-phosphate <=> D-glyceraldehyde + dihydroxyacetone phosphate, Homo sapiens"
xref: Reactome:REACT_235 "dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate, Homo sapiens"
xref: Reactome:REACT_28350 "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate, Dictyostelium discoideum"
xref: Reactome:REACT_29075 "D-fructose 1-phosphate <=> D-glyceraldehyde + dihydroxyacetone phosphate, Mus musculus"
xref: Reactome:REACT_29122 "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate, Drosophila melanogaster"
xref: Reactome:REACT_29507 "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate, Gallus gallus"
xref: Reactome:REACT_31345 "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate, Xenopus tropicalis"
xref: Reactome:REACT_33880 "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate, Sus scrofa"
xref: Reactome:REACT_34216 "D-fructose 1-phosphate <=> D-glyceraldehyde + dihydroxyacetone phosphate, Xenopus tropicalis"
xref: Reactome:REACT_34422 "dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate, Drosophila melanogaster"
xref: Reactome:REACT_34557 "D-fructose 1-phosphate <=> D-glyceraldehyde + dihydroxyacetone phosphate, Oryza sativa"
xref: Reactome:REACT_34732 "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate, Canis familiaris"
xref: Reactome:REACT_46393 "D-fructose 1-phosphate <=> D-glyceraldehyde + dihydroxyacetone phosphate, Bos taurus"
xref: Reactome:REACT_61775 "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate, Plasmodium falciparum"
xref: Reactome:REACT_77422 "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate, Bos taurus"
xref: Reactome:REACT_79711 "dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate, Arabidopsis thaliana"
xref: Reactome:REACT_79785 "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate, Caenorhabditis elegans"
xref: Reactome:REACT_80109 "D-fructose 1-phosphate <=> D-glyceraldehyde + dihydroxyacetone phosphate, Dictyostelium discoideum"
xref: Reactome:REACT_80843 "D-fructose 1-phosphate <=> D-glyceraldehyde + dihydroxyacetone phosphate, Caenorhabditis elegans"
xref: Reactome:REACT_82777 "dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate, Xenopus tropicalis"
xref: Reactome:REACT_83035 "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate, Mus musculus"
xref: Reactome:REACT_85023 "dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate, Gallus gallus"
xref: Reactome:REACT_86042 "dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate, Canis familiaris"
xref: Reactome:REACT_86101 "dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate, Rattus norvegicus"
xref: Reactome:REACT_87126 "D-fructose 1-phosphate <=> D-glyceraldehyde + dihydroxyacetone phosphate, Danio rerio"
xref: Reactome:REACT_88404 "D-fructose 1-phosphate <=> D-glyceraldehyde + dihydroxyacetone phosphate, Canis familiaris"
xref: Reactome:REACT_88447 "dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate, Plasmodium falciparum"
xref: Reactome:REACT_90018 "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate, Taeniopygia guttata"
xref: Reactome:REACT_90029 "D-fructose 1-phosphate <=> D-glyceraldehyde + dihydroxyacetone phosphate, Taeniopygia guttata"
xref: Reactome:REACT_91667 "D-fructose 1-phosphate <=> D-glyceraldehyde + dihydroxyacetone phosphate, Plasmodium falciparum"
xref: Reactome:REACT_91845 "dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate, Dictyostelium discoideum"
xref: Reactome:REACT_92822 "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate, Oryza sativa"
xref: Reactome:REACT_94406 "dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate, Danio rerio"
xref: Reactome:REACT_94423 "dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate, Taeniopygia guttata"
xref: Reactome:REACT_95451 "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate, Rattus norvegicus"
xref: Reactome:REACT_97153 "dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate, Sus scrofa"
xref: Reactome:REACT_97915 "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate, Arabidopsis thaliana"
xref: Reactome:REACT_98113 "D-fructose 1-phosphate <=> D-glyceraldehyde + dihydroxyacetone phosphate, Rattus norvegicus"
xref: Reactome:REACT_99298 "dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate, Bos taurus"
xref: RHEA:14732
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0004333
name: fumarate hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-malate = fumarate + H(2)O." [EC:4.2.1.2, RHEA:12463]
subset: gosubset_prok
synonym: "(S)-malate hydro-lyase (fumarate-forming)" EXACT [EC:4.2.1.2]
synonym: "(S)-malate hydro-lyase activity" EXACT [EC:4.2.1.2]
synonym: "fumarase activity" EXACT [EC:4.2.1.2]
synonym: "L-malate hydro-lyase activity" EXACT [EC:4.2.1.2]
xref: EC:4.2.1.2
xref: KEGG:R01082
xref: MetaCyc:FUMHYDR-RXN
xref: Reactome:REACT_100573 "Fumarate + H2O <=> (S)-Malate, Canis familiaris"
xref: Reactome:REACT_102283 "Fumarate + H2O <=> (S)-Malate, Taeniopygia guttata"
xref: Reactome:REACT_102637 "Fumarate + H2O <=> (S)-Malate, Bos taurus"
xref: Reactome:REACT_103835 "Fumarate + H2O <=> (S)-Malate, Gallus gallus"
xref: Reactome:REACT_104675 "Fumarate + H2O <=> (S)-Malate, Dictyostelium discoideum"
xref: Reactome:REACT_109085 "Fumarate + H2O <=> (S)-Malate, Oryza sativa"
xref: Reactome:REACT_115295 "Fumarate + H2O <=> (S)-Malate, Xenopus tropicalis"
xref: Reactome:REACT_115714 "fumarate + H2O <=> malate, Gallus gallus"
xref: Reactome:REACT_115901 "malate <=> fumarate + H2O, Gallus gallus"
xref: Reactome:REACT_1656 "Fumarate + H2O <=> (S)-Malate, Homo sapiens"
xref: Reactome:REACT_21360 "(S)-Malate <=> Fumarate + H2O, Homo sapiens"
xref: Reactome:REACT_33209 "Fumarate + H2O <=> (S)-Malate, Mus musculus"
xref: Reactome:REACT_77316 "Fumarate + H2O <=> (S)-Malate, Drosophila melanogaster"
xref: Reactome:REACT_82795 "Fumarate + H2O <=> (S)-Malate, Arabidopsis thaliana"
xref: Reactome:REACT_82946 "Fumarate + H2O <=> (S)-Malate, Caenorhabditis elegans"
xref: Reactome:REACT_90400 "Fumarate + H2O <=> (S)-Malate, Mycobacterium tuberculosis"
xref: Reactome:REACT_91925 "Fumarate + H2O <=> (S)-Malate, Danio rerio"
xref: Reactome:REACT_93250 "Fumarate + H2O <=> (S)-Malate, Saccharomyces cerevisiae"
xref: Reactome:REACT_93953 "Fumarate + H2O <=> (S)-Malate, Rattus norvegicus"
xref: Reactome:REACT_94620 "Fumarate + H2O <=> (S)-Malate, Schizosaccharomyces pombe"
xref: Reactome:REACT_96178 "Fumarate + H2O <=> (S)-Malate, Staphylococcus aureus N315"
xref: RHEA:12463
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0004334
name: fumarylacetoacetase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-fumarylacetoacetate + H(2)O = acetoacetate + fumarate + H(+)." [EC:3.7.1.2, RHEA:10247]
subset: gosubset_prok
synonym: "4-fumarylacetoacetate fumarylhydrolase activity" EXACT [EC:3.7.1.2]
synonym: "beta-diketonase activity" EXACT [EC:3.7.1.2]
synonym: "fumarylacetoacetate hydrolase activity" EXACT [EC:3.7.1.2]
xref: EC:3.7.1.2
xref: KEGG:R01364
xref: MetaCyc:FUMARYLACETOACETASE-RXN
xref: Reactome:REACT_101871 "fumarylacetoacetate => fumarate + acetoacetate, Bos taurus"
xref: Reactome:REACT_102851 "fumarylacetoacetate => fumarate + acetoacetate, Dictyostelium discoideum"
xref: Reactome:REACT_105315 "fumarylacetoacetate => fumarate + acetoacetate, Sus scrofa"
xref: Reactome:REACT_109988 "fumarylacetoacetate => fumarate + acetoacetate, Danio rerio"
xref: Reactome:REACT_1297 "fumarylacetoacetate => fumarate + acetoacetate, Homo sapiens"
xref: Reactome:REACT_31058 "fumarylacetoacetate => fumarate + acetoacetate, Caenorhabditis elegans"
xref: Reactome:REACT_31994 "fumarylacetoacetate => fumarate + acetoacetate, Taeniopygia guttata"
xref: Reactome:REACT_77401 "fumarylacetoacetate => fumarate + acetoacetate, Oryza sativa"
xref: Reactome:REACT_80968 "fumarylacetoacetate => fumarate + acetoacetate, Arabidopsis thaliana"
xref: Reactome:REACT_87154 "fumarylacetoacetate => fumarate + acetoacetate, Xenopus tropicalis"
xref: Reactome:REACT_87657 "fumarylacetoacetate => fumarate + acetoacetate, Mus musculus"
xref: Reactome:REACT_90501 "fumarylacetoacetate => fumarate + acetoacetate, Canis familiaris"
xref: Reactome:REACT_94208 "fumarylacetoacetate => fumarate + acetoacetate, Gallus gallus"
xref: Reactome:REACT_96671 "fumarylacetoacetate => fumarate + acetoacetate, Drosophila melanogaster"
xref: Reactome:REACT_97148 "fumarylacetoacetate => fumarate + acetoacetate, Rattus norvegicus"
xref: RHEA:10247
xref: UM-BBD_reactionID:r0107
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0004335
name: galactokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + 2 H(+)." [EC:2.7.1.6, RHEA:13556]
subset: gosubset_prok
synonym: "ATP:D-galactose 1-phosphotransferase activity" EXACT [EC:2.7.1.6]
synonym: "ATP:D-galactose-1-phosphotransferase activity" EXACT [EC:2.7.1.6]
synonym: "galactokinase (phosphorylating)" EXACT [EC:2.7.1.6]
xref: EC:2.7.1.6
xref: KEGG:R01092
xref: MetaCyc:GALACTOKIN-RXN
xref: Reactome:REACT_101502 "ATP + D-galactose => ADP + D-galactose 1-phosphate, Escherichia coli"
xref: Reactome:REACT_104899 "ATP + D-galactose => ADP + D-galactose 1-phosphate, Bos taurus"
xref: Reactome:REACT_106662 "ATP + D-galactose => ADP + D-galactose 1-phosphate, Rattus norvegicus"
xref: Reactome:REACT_107666 "ATP + D-galactose => ADP + D-galactose 1-phosphate, Danio rerio"
xref: Reactome:REACT_113809 "ATP + D-galactose => ADP + D-galactose 1-phosphate, Mycobacterium tuberculosis"
xref: Reactome:REACT_1246 "ATP + D-galactose => ADP + D-galactose 1-phosphate, Homo sapiens"
xref: Reactome:REACT_32797 "ATP + D-galactose => ADP + D-galactose 1-phosphate, Canis familiaris"
xref: Reactome:REACT_89577 "ATP + D-galactose => ADP + D-galactose 1-phosphate, Mus musculus"
xref: Reactome:REACT_91072 "ATP + D-galactose => ADP + D-galactose 1-phosphate, Sus scrofa"
xref: Reactome:REACT_91251 "ATP + D-galactose => ADP + D-galactose 1-phosphate, Gallus gallus"
xref: Reactome:REACT_94404 "ATP + D-galactose => ADP + D-galactose 1-phosphate, Xenopus tropicalis"
xref: Reactome:REACT_99486 "ATP + D-galactose => ADP + D-galactose 1-phosphate, Taeniopygia guttata"
xref: RHEA:13556
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0004336
name: galactosylceramidase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-galactosyl-N-acylsphingosine + H2O = D-galactose + N-acylsphingosine." [EC:3.2.1.46]
synonym: "beta-galactocerebrosidase activity" EXACT [EC:3.2.1.46]
synonym: "beta-galactosylceramidase activity" EXACT [EC:3.2.1.46]
synonym: "ceramide galactosidase activity" EXACT [EC:3.2.1.46]
synonym: "cerebroside beta-galactosidase activity" EXACT [EC:3.2.1.46]
synonym: "cerebroside galactosidase activity" EXACT [EC:3.2.1.46]
synonym: "D-galactosyl-N-acylsphingosine galactohydrolase activity" EXACT [EC:3.2.1.46]
synonym: "galactocerebrosidase activity" EXACT [EC:3.2.1.46]
synonym: "galactocerebroside beta-galactosidase activity" EXACT [EC:3.2.1.46]
synonym: "galactocerebroside galactosidase activity" EXACT [EC:3.2.1.46]
synonym: "galactocerebroside-beta-D-galactosidase activity" EXACT [EC:3.2.1.46]
synonym: "galactosylceramidase I" RELATED [EC:3.2.1.46]
synonym: "galactosylceramide beta-galactosidase activity" EXACT [EC:3.2.1.46]
synonym: "galactosylcerebrosidase activity" EXACT [EC:3.2.1.46]
synonym: "galcerase activity" EXACT [EC:3.2.1.46]
synonym: "lactosylceramidase activity" EXACT [EC:3.2.1.46]
synonym: "lactosylceramidase I" RELATED [EC:3.2.1.46]
xref: EC:3.2.1.46
xref: MetaCyc:GALACTOSYLCERAMIDASE-RXN
xref: Reactome:REACT_115737 "Galactocerebrosidase cleaves the galactosyl bond of galactocerebroside to form ceramide, Homo sapiens"
xref: RHEA:14300
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0004337
name: geranyltranstransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = 2-trans,6-trans-farnesyl diphosphate + diphosphate." [EC:2.5.1.10, RHEA:19364]
comment: Note that this is the second step in the formation of farnesyl diphosphate. The first step is 'dimethylallyltransferase activity ; GO:0004161'. Consider also annotating to the biological process term 'farnesyl diphosphate biosynthetic process ; GO:0045337'.
subset: gosubset_prok
synonym: "farnesyl diphosphate synthetase activity" EXACT [EC:2.5.1.10]
synonym: "farnesyl pyrophosphate synthetase activity" EXACT []
synonym: "farnesyl-diphosphate synthase activity" EXACT []
synonym: "farnesylpyrophosphate synthetase activity" EXACT [EC:2.5.1.10]
synonym: "FPP synthetase activity" EXACT [EC:2.5.1.10]
synonym: "geranyl transferase I" RELATED [EC:2.5.1.10]
synonym: "geranyl-diphosphate:isopentenyl-diphosphate geranyltranstransferase activity" EXACT [EC:2.5.1.10]
synonym: "geranyltransferase activity" EXACT [EC:2.5.1.10]
xref: EC:2.5.1.10
xref: KEGG:R02003
xref: MetaCyc:FPPSYN-RXN
xref: Reactome:REACT_106226 "Another isopentenyl pyrophosphate is added to geranyl pyrophosphate, Xenopus tropicalis"
xref: Reactome:REACT_106273 "Another isopentenyl pyrophosphate is added to geranyl pyrophosphate, Mus musculus"
xref: Reactome:REACT_106937 "Another isopentenyl pyrophosphate is added to geranyl pyrophosphate, Oryza sativa"
xref: Reactome:REACT_108353 "Another isopentenyl pyrophosphate is added to geranyl pyrophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_110008 "Another isopentenyl pyrophosphate is added to geranyl pyrophosphate, Rattus norvegicus"
xref: Reactome:REACT_31479 "Another isopentenyl pyrophosphate is added to geranyl pyrophosphate, Gallus gallus"
xref: Reactome:REACT_32096 "Another isopentenyl pyrophosphate is added to geranyl pyrophosphate, Canis familiaris"
xref: Reactome:REACT_32332 "Another isopentenyl pyrophosphate is added to geranyl pyrophosphate, Sus scrofa"
xref: Reactome:REACT_80399 "Another isopentenyl pyrophosphate is added to geranyl pyrophosphate, Bos taurus"
xref: Reactome:REACT_80850 "Another isopentenyl pyrophosphate is added to geranyl pyrophosphate, Taeniopygia guttata"
xref: Reactome:REACT_82492 "Another isopentenyl pyrophosphate is added to geranyl pyrophosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_86369 "Another isopentenyl pyrophosphate is added to geranyl pyrophosphate, Drosophila melanogaster"
xref: Reactome:REACT_87629 "Another isopentenyl pyrophosphate is added to geranyl pyrophosphate, Plasmodium falciparum"
xref: Reactome:REACT_9451 "Another isopentenyl pyrophosphate is added to geranyl pyrophosphate, Homo sapiens"
xref: Reactome:REACT_95036 "Another isopentenyl pyrophosphate is added to geranyl pyrophosphate, Caenorhabditis elegans"
xref: Reactome:REACT_95560 "Another isopentenyl pyrophosphate is added to geranyl pyrophosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_96641 "Another isopentenyl pyrophosphate is added to geranyl pyrophosphate, Danio rerio"
xref: Reactome:REACT_99168 "Another isopentenyl pyrophosphate is added to geranyl pyrophosphate, Arabidopsis thaliana"
xref: RHEA:19364
is_a: GO:0004659 ! prenyltransferase activity

[Term]
id: GO:0004338
name: glucan exo-1,3-beta-glucosidase activity
namespace: molecular_function
def: "Catalysis of the successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose." [EC:3.2.1.58]
synonym: "1,3-beta-glucan glucohydrolase activity" BROAD [EC:3.2.1.58]
synonym: "beta-1,3-glucan exo-hydrolase activity" EXACT [EC:3.2.1.58]
synonym: "exo (1->3)-beta-glucanase activity" EXACT [EC:3.2.1.58]
synonym: "exo-1,3-beta-D-glucanase activity" EXACT [EC:3.2.1.58]
synonym: "exo-1,3-beta-glucanase activity" EXACT [EC:3.2.1.58]
synonym: "exo-1,3-beta-glucosidase activity" EXACT [EC:3.2.1.58]
synonym: "exo-beta-(1->3)-D-glucanase activity" EXACT [EC:3.2.1.58]
synonym: "exo-beta-(1->3)-glucanohydrolase activity" EXACT [EC:3.2.1.58]
synonym: "exo-beta-1,3-D-glucanase activity" EXACT [EC:3.2.1.58]
synonym: "exo-beta-1,3-glucanase activity" EXACT [EC:3.2.1.58]
synonym: "glucan 1,3-beta-glucosidase activity" BROAD [GOC:mah]
xref: EC:3.2.1.58
xref: MetaCyc:3.2.1.58-RXN
is_a: GO:0008422 ! beta-glucosidase activity

[Term]
id: GO:0004339
name: glucan 1,4-alpha-glucosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal (1->4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose." [EC:3.2.1.3]
comment: Note that this term is not a child of 'alpha-glucosidase activity ; GO:0090599', because in the reaction represented by GO:0004339 results in the release of beta-D-glucose, whereas in GO:0090599 alpha-D-glucose is released.
subset: gosubset_prok
synonym: "1,4-alpha-D-glucan glucohydrolase activity" EXACT [EC:3.2.1.3]
synonym: "amyloglucosidase activity" EXACT [EC:3.2.1.3]
synonym: "exo-1,4-alpha-glucosidase activity" EXACT [EC:3.2.1.3]
synonym: "gamma-1,4-glucan glucohydrolase activity" EXACT [EC:3.2.1.3]
synonym: "gamma-amylase activity" EXACT [EC:3.2.1.3]
synonym: "glucoamylase activity" EXACT []
synonym: "glucose amylase activity" EXACT [EC:3.2.1.3]
synonym: "lysosomal alpha-glucosidase activity" BROAD [EC:3.2.1.3]
xref: EC:3.2.1.3
xref: MetaCyc:3.2.1.3-RXN
is_a: GO:0015926 ! glucosidase activity

[Term]
id: GO:0004340
name: glucokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-glucose = ADP + D-glucose-6-phosphate." [EC:2.7.1.2]
subset: gosubset_prok
synonym: "ATP:D-glucose 6-phosphotransferase activity" EXACT [EC:2.7.1.2]
synonym: "glucokinase (phosphorylating)" EXACT [EC:2.7.1.2]
synonym: "glucose kinase activity" EXACT [EC:2.7.1.2]
xref: EC:2.7.1.2
xref: MetaCyc:GLUCOKIN-RXN
xref: Reactome:REACT_109618 "alpha-D-Glucose + ATP => alpha-D-glucose 6-phosphate + ADP, Sus scrofa"
xref: Reactome:REACT_115950 "glucose + ATP => glucose 6-phosphate + ADP, Gallus gallus"
xref: Reactome:REACT_1827 "alpha-D-Glucose + ATP => alpha-D-glucose 6-phosphate + ADP, Homo sapiens"
xref: Reactome:REACT_28331 "alpha-D-Glucose + ATP => alpha-D-glucose 6-phosphate + ADP, Caenorhabditis elegans"
xref: Reactome:REACT_28504 "alpha-D-Glucose + ATP => alpha-D-glucose 6-phosphate + ADP, Taeniopygia guttata"
xref: Reactome:REACT_31619 "alpha-D-Glucose + ATP => alpha-D-glucose 6-phosphate + ADP, Oryza sativa"
xref: Reactome:REACT_33904 "alpha-D-Glucose + ATP => alpha-D-glucose 6-phosphate + ADP, Arabidopsis thaliana"
xref: Reactome:REACT_34118 "alpha-D-Glucose + ATP => alpha-D-glucose 6-phosphate + ADP, Plasmodium falciparum"
xref: Reactome:REACT_80323 "alpha-D-Glucose + ATP => alpha-D-glucose 6-phosphate + ADP, Rattus norvegicus"
xref: Reactome:REACT_81488 "alpha-D-Glucose + ATP => alpha-D-glucose 6-phosphate + ADP, Danio rerio"
xref: Reactome:REACT_82793 "alpha-D-Glucose + ATP => alpha-D-glucose 6-phosphate + ADP, Gallus gallus"
xref: Reactome:REACT_84021 "alpha-D-Glucose + ATP => alpha-D-glucose 6-phosphate + ADP, Bos taurus"
xref: Reactome:REACT_85927 "alpha-D-Glucose + ATP => alpha-D-glucose 6-phosphate + ADP, Schizosaccharomyces pombe"
xref: Reactome:REACT_88172 "alpha-D-Glucose + ATP => alpha-D-glucose 6-phosphate + ADP, Xenopus tropicalis"
xref: Reactome:REACT_90073 "alpha-D-Glucose + ATP => alpha-D-glucose 6-phosphate + ADP, Saccharomyces cerevisiae"
xref: Reactome:REACT_92495 "alpha-D-Glucose + ATP => alpha-D-glucose 6-phosphate + ADP, Mus musculus"
xref: Reactome:REACT_96462 "alpha-D-Glucose + ATP => alpha-D-glucose 6-phosphate + ADP, Canis familiaris"
xref: RHEA:17828
is_a: GO:0004396 ! hexokinase activity
relationship: part_of GO:0051156 ! glucose 6-phosphate metabolic process

[Term]
id: GO:0004341
name: gluconolactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucono-1,5-lactone + H2O = D-gluconate." [EC:3.1.1.17]
subset: gosubset_prok
synonym: "aldonolactonase activity" EXACT [EC:3.1.1.17]
synonym: "D-glucono-1,5-lactone lactonohydrolase activity" EXACT [EC:3.1.1.17]
synonym: "glucono-delta-lactonase activity" EXACT [EC:3.1.1.17]
synonym: "gulonolactonase activity" EXACT [EC:3.1.1.17]
synonym: "lactonase activity" BROAD [EC:3.1.1.17]
xref: EC:3.1.1.17
xref: MetaCyc:GLUCONOLACT-RXN
xref: RHEA:10443
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0004342
name: glucosamine-6-phosphate deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucosamine 6-phosphate + H(2)O = beta-D-fructose 6-phosphate + NH(4)(+)." [EC:3.5.99.6, RHEA:12175]
comment: Note that this function was formerly EC:5.3.1.10.
subset: gosubset_prok
synonym: "2-amino-2-deoxy-D-glucose-6-phosphate aminohydrolase (ketol isomerizing)" EXACT [EC:3.5.99.6]
synonym: "aminodeoxyglucosephosphate isomerase activity" EXACT [EC:3.5.99.6]
synonym: "GlcN6P deaminase activity" EXACT [EC:3.5.99.6]
synonym: "glucosamine phosphate deaminase activity" EXACT [EC:3.5.99.6]
synonym: "glucosamine-6-phosphate isomerase activity" EXACT [EC:3.5.99.6]
synonym: "glucosaminephosphate isomerase" BROAD [EC:3.5.99.6]
synonym: "phosphoglucosamine isomerase activity" EXACT [EC:3.5.99.6]
synonym: "phosphoglucosaminisomerase activity" EXACT [EC:3.5.99.6]
xref: EC:3.5.99.6
xref: KEGG:R00765
xref: MetaCyc:GLUCOSAMINE-6-P-DEAMIN-RXN
xref: RHEA:12175
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0004343
name: glucosamine 6-phosphate N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)." [EC:2.3.1.4, RHEA:10295]
subset: gosubset_prok
synonym: "acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase activity" EXACT [EC:2.3.1.4]
synonym: "aminodeoxyglucosephosphate acetyltransferase activity" EXACT [EC:2.3.1.4]
synonym: "D-glucosamine-6-P N-acetyltransferase activity" EXACT [EC:2.3.1.4]
synonym: "glucosamine 6-phosphate acetylase activity" EXACT [EC:2.3.1.4]
synonym: "glucosamine-6-phosphate acetylase activity" EXACT [EC:2.3.1.4]
synonym: "glucosamine-phosphate N-acetyltransferase activity" EXACT []
synonym: "N-acetylglucosamine-6-phosphate synthase activity" EXACT [EC:2.3.1.4]
synonym: "phosphoglucosamine acetylase activity" EXACT [EC:2.3.1.4]
synonym: "phosphoglucosamine N-acetylase activity" EXACT [EC:2.3.1.4]
synonym: "phosphoglucosamine transacetylase activity" EXACT [EC:2.3.1.4]
xref: EC:2.3.1.4
xref: KEGG:R02058
xref: MetaCyc:GLUCOSAMINEPNACETYLTRANS-RXN
xref: Reactome:REACT_22233 "Acetylation of glucosamine 6-phosphate to GlcNAc6P, Homo sapiens"
xref: RHEA:10295
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0004344
name: glucose dehydrogenase activity
namespace: molecular_function
alt_id: GO:0008708
def: "Catalysis of the reaction: D-glucose + acceptor = D-glucono-1,5-lactone + reduced acceptor." [EC:1.1.99.10]
synonym: "D-glucose:(acceptor) 1-oxidoreductase" EXACT [EC:1.1.99.10]
synonym: "D-glucose:acceptor 1-oxidoreductase" EXACT [EC:1.1.5.2]
synonym: "glucose dehydrogenase (acceptor) activity" EXACT []
synonym: "glucose dehydrogenase (Aspergillus) activity" NARROW [EC:1.1.99.10]
synonym: "glucose dehydrogenase (decarboxylating)" EXACT [EC:1.1.99.10]
xref: EC:1.1.99.10
xref: KEGG:R00305
xref: MetaCyc:GLUCOSE-DEHYDROGENASE-ACCEPTOR-RXN
xref: RHEA:24543
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0004345
name: glucose-6-phosphate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+." [EC:1.1.1.49]
subset: gosubset_prok
synonym: "6-phosphoglucose dehydrogenas" RELATED []
synonym: "6-phosphoglucose dehydrogenase activity" EXACT []
synonym: "D-glucose 6-phosphate dehydrogenase activity" EXACT []
synonym: "D-glucose-6-phosphate:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.49]
synonym: "Entner-doudoroff enzyme" RELATED [EC:1.1.1.49]
synonym: "G6PD activity" EXACT [EC:1.1.1.49]
synonym: "G6PDH" EXACT []
synonym: "GDH" RELATED []
synonym: "glucose 6-phosphate dehydrogenase (NADP) activity" EXACT []
synonym: "glucose-6-phosphate 1-dehydrogenase activity" EXACT []
synonym: "NADP-dependent glucose 6-phosphate dehydrogenase activity" EXACT []
synonym: "NADP-glucose-6-phosphate dehydrogenase activity" EXACT []
synonym: "Zwischenferment" RELATED []
synonym: "zwischenferment" RELATED [EC:1.1.1.49]
xref: EC:1.1.1.49
xref: MetaCyc:GLU6PDEHYDROG-RXN
xref: Reactome:REACT_102558 "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+, Mus musculus"
xref: Reactome:REACT_104275 "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+, Rattus norvegicus"
xref: Reactome:REACT_112685 "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+, Plasmodium falciparum"
xref: Reactome:REACT_114196 "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+, Xenopus tropicalis"
xref: Reactome:REACT_114740 "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+, Dictyostelium discoideum"
xref: Reactome:REACT_1868 "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+, Homo sapiens"
xref: Reactome:REACT_28663 "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+, Staphylococcus aureus N315"
xref: Reactome:REACT_29982 "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+, Mycobacterium tuberculosis"
xref: Reactome:REACT_31126 "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+, Escherichia coli"
xref: Reactome:REACT_33226 "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+, Danio rerio"
xref: Reactome:REACT_33546 "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+, Arabidopsis thaliana"
xref: Reactome:REACT_34758 "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+, Oryza sativa"
xref: Reactome:REACT_80140 "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+, Canis familiaris"
xref: Reactome:REACT_83159 "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+, Drosophila melanogaster"
xref: Reactome:REACT_84676 "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+, Saccharomyces cerevisiae"
xref: Reactome:REACT_87680 "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+, Bos taurus"
xref: Reactome:REACT_89131 "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+, Schizosaccharomyces pombe"
xref: Reactome:REACT_90405 "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+, Caenorhabditis elegans"
xref: RHEA:15844
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004346
name: glucose-6-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucopyranose 6-phosphate + H2O = D-glucose + phosphate. D-glucopyranose is also known as D-glucose 6-phosphate." [EC:3.1.3.9, RHEA:16692]
subset: gosubset_prok
synonym: "D-glucose-6-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.9]
synonym: "glucose 6-phosphate phosphatase activity" EXACT [EC:3.1.3.9]
xref: EC:3.1.3.9
xref: KEGG:R00303
xref: MetaCyc:GLUCOSE-6-PHOSPHATASE-RXN
xref: Reactome:REACT_101074 "alpha-D-Glucose 6-phosphate + H2O => alpha-D-Glucose + Orthophosphate, Canis familiaris"
xref: Reactome:REACT_101088 "alpha-D-Glucose 6-phosphate + H2O => alpha-D-Glucose + Orthophosphate, Danio rerio"
xref: Reactome:REACT_115845 "glucose 6-phosphate + H2O => glucose + phosphate, Gallus gallus"
xref: Reactome:REACT_1682 "alpha-D-Glucose 6-phosphate + H2O => alpha-D-Glucose + Orthophosphate, Homo sapiens"
xref: Reactome:REACT_30178 "alpha-D-Glucose 6-phosphate + H2O => alpha-D-Glucose + Orthophosphate, Taeniopygia guttata"
xref: Reactome:REACT_33577 "alpha-D-Glucose 6-phosphate + H2O => alpha-D-Glucose + Orthophosphate, Rattus norvegicus"
xref: Reactome:REACT_85407 "alpha-D-Glucose 6-phosphate + H2O => alpha-D-Glucose + Orthophosphate, Xenopus tropicalis"
xref: Reactome:REACT_85737 "alpha-D-Glucose 6-phosphate + H2O => alpha-D-Glucose + Orthophosphate, Mus musculus"
xref: Reactome:REACT_89941 "alpha-D-Glucose 6-phosphate + H2O => alpha-D-Glucose + Orthophosphate, Bos taurus"
xref: Reactome:REACT_94617 "alpha-D-Glucose 6-phosphate + H2O => alpha-D-Glucose + Orthophosphate, Gallus gallus"
xref: Reactome:REACT_94861 "alpha-D-Glucose 6-phosphate + H2O => alpha-D-Glucose + Orthophosphate, Drosophila melanogaster"
xref: Reactome:REACT_97985 "alpha-D-Glucose 6-phosphate + H2O => alpha-D-Glucose + Orthophosphate, Sus scrofa"
xref: RHEA:16692
is_a: GO:0050309 ! sugar-terminal-phosphatase activity

[Term]
id: GO:0004347
name: glucose-6-phosphate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate." [EC:5.3.1.9]
subset: gosubset_prok
synonym: "D-glucose-6-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.9]
synonym: "D-glucose-6-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.9]
synonym: "glucose phosphate isomerase activity" EXACT [EC:5.3.1.9]
synonym: "hexose monophosphate isomerase activity" BROAD [EC:5.3.1.9]
synonym: "hexose phosphate isomerase activity" EXACT [EC:5.3.1.9]
synonym: "hexosephosphate isomerase activity" BROAD [EC:5.3.1.9]
synonym: "oxoisomerase activity" RELATED [EC:5.3.1.9]
synonym: "phosphoglucoisomerase activity" EXACT [EC:5.3.1.9]
synonym: "phosphoglucose isomerase activity" EXACT [EC:5.3.1.9]
synonym: "phosphohexoisomerase activity" BROAD [EC:5.3.1.9]
synonym: "phosphohexomutase activity" BROAD [EC:5.3.1.9]
synonym: "phosphohexose isomerase activity" BROAD [EC:5.3.1.9]
synonym: "phosphosaccharomutase activity" BROAD [EC:5.3.1.9]
xref: EC:5.3.1.9
xref: MetaCyc:PGLUCISOM-RXN
xref: Reactome:REACT_100001 "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate, Xenopus tropicalis"
xref: Reactome:REACT_100164 "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate, Danio rerio"
xref: Reactome:REACT_100236 "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate, Bos taurus"
xref: Reactome:REACT_100583 "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate, Plasmodium falciparum"
xref: Reactome:REACT_101103 "D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate, Drosophila melanogaster"
xref: Reactome:REACT_102104 "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate, Caenorhabditis elegans"
xref: Reactome:REACT_102404 "D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate, Escherichia coli"
xref: Reactome:REACT_103273 "D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_105129 "D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate, Bos taurus"
xref: Reactome:REACT_105396 "D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate, Xenopus tropicalis"
xref: Reactome:REACT_106541 "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate, Rattus norvegicus"
xref: Reactome:REACT_107983 "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate, Gallus gallus"
xref: Reactome:REACT_109795 "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate, Mus musculus"
xref: Reactome:REACT_109950 "D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_110852 "D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate, Plasmodium falciparum"
xref: Reactome:REACT_113483 "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate, Arabidopsis thaliana"
xref: Reactome:REACT_115143 "D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate, Arabidopsis thaliana"
xref: Reactome:REACT_115648 "glucose 6-phosphate <=> fructose 6-phosphate, Gallus gallus"
xref: Reactome:REACT_115859 "fructose 6-phosphate <=> glucose 6-phosphate, Gallus gallus"
xref: Reactome:REACT_1255 "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate, Homo sapiens"
xref: Reactome:REACT_1690 "D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate, Homo sapiens"
xref: Reactome:REACT_29005 "D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate, Caenorhabditis elegans"
xref: Reactome:REACT_30934 "D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate, Mycobacterium tuberculosis"
xref: Reactome:REACT_32507 "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate, Escherichia coli"
xref: Reactome:REACT_33390 "D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate, Rattus norvegicus"
xref: Reactome:REACT_78538 "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate, Mycobacterium tuberculosis"
xref: Reactome:REACT_78791 "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate, Dictyostelium discoideum"
xref: Reactome:REACT_79357 "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate, Taeniopygia guttata"
xref: Reactome:REACT_79978 "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate, Canis familiaris"
xref: Reactome:REACT_82677 "D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate, Sus scrofa"
xref: Reactome:REACT_85092 "D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate, Canis familiaris"
xref: Reactome:REACT_85936 "D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate, Mus musculus"
xref: Reactome:REACT_86098 "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_87510 "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate, Staphylococcus aureus N315"
xref: Reactome:REACT_90932 "D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate, Staphylococcus aureus N315"
xref: Reactome:REACT_94008 "D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate, Taeniopygia guttata"
xref: Reactome:REACT_96038 "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_97996 "D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate, Gallus gallus"
xref: Reactome:REACT_98117 "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate, Drosophila melanogaster"
xref: Reactome:REACT_98949 "D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate, Danio rerio"
xref: Reactome:REACT_99481 "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate, Sus scrofa"
xref: Reactome:REACT_99765 "D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate, Dictyostelium discoideum"
xref: RHEA:11819
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0004348
name: glucosylceramidase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine." [EC:3.2.1.45]
subset: gosubset_prok
synonym: "acid beta-glucosidase activity" EXACT [EC:3.2.1.45]
synonym: "beta-D-glucocerebrosidase activity" EXACT [EC:3.2.1.45]
synonym: "beta-glucocerebrosidase activity" EXACT [EC:3.2.1.45]
synonym: "beta-glucosylceramidase activity" EXACT [EC:3.2.1.45]
synonym: "ceramide glucosidase activity" EXACT [EC:3.2.1.45]
synonym: "D-glucosyl-N-acylsphingosine glucohydrolase activity" EXACT [EC:3.2.1.45]
synonym: "GlcCer-beta-glucosidase activity" EXACT [EC:3.2.1.45]
synonym: "glucocerebrosidase activity" EXACT [EC:3.2.1.45]
synonym: "glucosphingosine glucosylhydrolase activity" EXACT [EC:3.2.1.45]
synonym: "glucosylcerebrosidase activity" EXACT [EC:3.2.1.45]
synonym: "glucosylsphingosine beta-D-glucosidase activity" EXACT [EC:3.2.1.45]
synonym: "glucosylsphingosine beta-glucosidase activity" EXACT [EC:3.2.1.45]
synonym: "psychosine hydrolase activity" EXACT [EC:3.2.1.45]
xref: EC:3.2.1.45
xref: MetaCyc:GLUCOSYLCERAMIDASE-RXN
xref: Reactome:REACT_115656 "Glucosylceramidase cleaves the glucosidic bond of glucocerebroside to form ceramide, Homo sapiens"
xref: Reactome:REACT_115663 "Glucosylceramidase 3 cleaves the glucosidic bond of glucocerebroside to form ceramide (cytosol), Homo sapiens"
xref: Reactome:REACT_115724 "Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane), Homo sapiens"
xref: RHEA:13272
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0004349
name: glutamate 5-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamate + ATP = L-glutamyl 5-phosphate + ADP + H(+)." [EC:2.7.2.11, RHEA:14880]
subset: gosubset_prok
synonym: "ATP-L-glutamate 5-phosphotransferase activity" EXACT [EC:2.7.2.11]
synonym: "ATP:gamma-L-glutamate phosphotransferase activity" EXACT [EC:2.7.2.11]
synonym: "ATP:L-glutamate 5-phosphotransferase activity" EXACT [EC:2.7.2.11]
synonym: "gamma-glutamate kinase activity" EXACT [EC:2.7.2.11]
synonym: "gamma-glutamyl kinase activity" EXACT [EC:2.7.2.11]
synonym: "glutamate kinase activity" EXACT [EC:2.7.2.11]
xref: EC:2.7.2.11
xref: KEGG:R00239
xref: MetaCyc:GLUTKIN-RXN
xref: RHEA:14880
is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor
is_a: GO:0019202 ! amino acid kinase activity

[Term]
id: GO:0004350
name: glutamate-5-semialdehyde dehydrogenase activity
namespace: molecular_function
alt_id: GO:0001513
def: "Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP(+) + phosphate = L-glutamyl 5-phosphate + H(+) + NADPH." [EC:1.2.1.41, RHEA:19544]
subset: gosubset_prok
synonym: "beta-glutamylphosphate reductase activity" EXACT [EC:1.2.1.41]
synonym: "gamma-glutamyl phosphate reductase activity" EXACT [EC:1.2.1.41]
synonym: "gamma-glutamylphosphate reductase activity" EXACT [EC:1.2.1.41]
synonym: "glutamate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.41]
synonym: "glutamate-gamma-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.41]
synonym: "glutamate-phosphate reductase activity" EXACT []
synonym: "glutamyl-gamma-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.41]
synonym: "glutamylphosphate reductase activity" EXACT []
synonym: "L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)" EXACT [EC:1.2.1.41]
xref: EC:1.2.1.41
xref: KEGG:R03313
xref: MetaCyc:GLUTSEMIALDEHYDROG-RXN
xref: RHEA:19544
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004351
name: glutamate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2." [EC:4.1.1.15]
subset: gosubset_prok
synonym: "aspartic alpha-decarboxylase" BROAD [EC:4.1.1.15]
synonym: "cysteic acid decarboxylase activity" EXACT [EC:4.1.1.15]
synonym: "gamma-glutamate decarboxylase activity" EXACT [EC:4.1.1.15]
synonym: "L-aspartate-alpha-decarboxylase activity" EXACT [EC:4.1.1.15]
synonym: "L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming)" EXACT [EC:4.1.1.15]
synonym: "L-glutamate 1-carboxy-lyase activity" EXACT [EC:4.1.1.15]
synonym: "L-glutamate alpha-decarboxylase activity" EXACT [EC:4.1.1.15]
synonym: "L-glutamic acid decarboxylase activity" EXACT [EC:4.1.1.15]
synonym: "L-glutamic decarboxylase activity" EXACT [EC:4.1.1.15]
xref: EC:4.1.1.15
xref: MetaCyc:GLUTDECARBOX-RXN
xref: Reactome:REACT_23866 "Synthesis of GABA by GAD2, Homo sapiens"
xref: Reactome:REACT_23937 "Synthesis of GABA by GAD1, Homo sapiens"
xref: RHEA:17788
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004352
name: glutamate dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+." [EC:1.4.1.2]
subset: gosubset_prok
synonym: "glutamate dehydrogenase (NAD)" EXACT [EC:1.4.1.2]
synonym: "glutamate oxidoreductase activity" EXACT [EC:1.4.1.2]
synonym: "glutamic acid dehydrogenase" BROAD [EC:1.4.1.2]
synonym: "glutamic dehydrogenase activity" BROAD [EC:1.4.1.2]
synonym: "L-glutamate dehydrogenase" BROAD [EC:1.4.1.2]
synonym: "L-glutamate:NAD+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.2]
synonym: "NAD-dependent glutamate dehydrogenase activity" EXACT [EC:1.4.1.2]
synonym: "NAD-dependent glutamic dehydrogenase activity" EXACT [EC:1.4.1.2]
synonym: "NAD-glutamate dehydrogenase activity" EXACT [EC:1.4.1.2]
synonym: "NAD-linked glutamate dehydrogenase activity" EXACT [EC:1.4.1.2]
synonym: "NAD-linked glutamic dehydrogenase activity" EXACT [EC:1.4.1.2]
synonym: "NAD-specific glutamate dehydrogenase activity" EXACT [EC:1.4.1.2]
synonym: "NAD-specific glutamic dehydrogenase activity" EXACT [EC:1.4.1.2]
synonym: "NAD:glutamate oxidoreductase activity" EXACT [EC:1.4.1.2]
synonym: "NADH-linked glutamate dehydrogenase activity" EXACT [EC:1.4.1.2]
xref: EC:1.4.1.2
xref: MetaCyc:GLUTAMATE-DEHYDROGENASE-RXN
xref: RHEA:15136
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004353
name: glutamate dehydrogenase [NAD(P)+] activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+." [EC:1.4.1.3]
comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step.
subset: gosubset_prok
synonym: "glutamate biosynthesis, using glutamate dehydrogenase (NAD(P)+)" RELATED []
synonym: "glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+)" RELATED []
synonym: "glutamic dehydrogenase activity" BROAD [EC:1.4.1.3]
synonym: "L-glutamate:NAD(P)+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.3]
xref: EC:1.4.1.3
xref: MetaCyc:GLUTAMATE-DEHYDROGENASE-NADP+-RXN
xref: MetaCyc:GLUTAMATE-SYN2-PWY
xref: Reactome:REACT_100655 "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1], Drosophila melanogaster"
xref: Reactome:REACT_100656 "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1], Gallus gallus"
xref: Reactome:REACT_104090 "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1], Taeniopygia guttata"
xref: Reactome:REACT_105114 "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1], Dictyostelium discoideum"
xref: Reactome:REACT_106901 "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1], Gallus gallus"
xref: Reactome:REACT_109912 "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1], Danio rerio"
xref: Reactome:REACT_112437 "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1], Canis familiaris"
xref: Reactome:REACT_112733 "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1], Staphylococcus aureus N315"
xref: Reactome:REACT_113249 "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1], Staphylococcus aureus N315"
xref: Reactome:REACT_114470 "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1], Canis familiaris"
xref: Reactome:REACT_1896 "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1], Homo sapiens"
xref: Reactome:REACT_28386 "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1], Drosophila melanogaster"
xref: Reactome:REACT_710 "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1], Homo sapiens"
xref: Reactome:REACT_78365 "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1], Mus musculus"
xref: Reactome:REACT_82868 "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1], Xenopus tropicalis"
xref: Reactome:REACT_83965 "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1], Dictyostelium discoideum"
xref: Reactome:REACT_90113 "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1], Taeniopygia guttata"
xref: Reactome:REACT_93428 "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1], Caenorhabditis elegans"
xref: Reactome:REACT_94386 "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1], Caenorhabditis elegans"
xref: Reactome:REACT_95081 "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1], Mus musculus"
xref: Reactome:REACT_95259 "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1], Danio rerio"
xref: Reactome:REACT_96021 "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1], Xenopus tropicalis"
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004354
name: glutamate dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+." [EC:1.4.1.4]
subset: gosubset_prok
synonym: "dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate))" EXACT [EC:1.4.1.4]
synonym: "glutamic acid dehydrogenase" BROAD [EC:1.4.1.4]
synonym: "glutamic dehydrogenase activity" BROAD [EC:1.4.1.4]
synonym: "L-glutamate dehydrogenase" BROAD [EC:1.4.1.4]
synonym: "L-glutamate:NADP+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.4]
synonym: "L-glutamic acid dehydrogenase activity" EXACT [EC:1.4.1.4]
synonym: "NAD(P)-glutamate dehydrogenase activity" EXACT [EC:1.4.1.4]
synonym: "NAD(P)H-dependent glutamate dehydrogenase activity" EXACT [EC:1.4.1.4]
xref: EC:1.4.1.4
xref: MetaCyc:GLUTDEHYD-RXN
xref: MetaCyc:GLUTSYNIII-PWY
xref: RHEA:11615
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004355
name: glutamate synthase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 L-glutamate + NADP(+) = 2-oxoglutarate + L-glutamine + H(+) + NADPH. This is a two-step reaction: (a) L-glutamate + NH3 = L-glutamine + H2O, (b) L-glutamate + NADP+ + H2O = NH3 + 2-oxoglutarate + NADPH + H+." [EC:1.4.1.13, RHEA:15504]
comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step.
subset: gosubset_prok
synonym: "glutamate (reduced nicotinamide adenine dinucleotide phosphate) synthase activity" EXACT [EC:1.4.1.13]
synonym: "glutamate synthetase (NADP) activity" EXACT [EC:1.4.1.13]
synonym: "glutamine amide-2-oxoglutarate aminotransferase (oxidoreductase, NADP) activity" EXACT [EC:1.4.1.13]
synonym: "glutamine-ketoglutaric aminotransferase activity" EXACT [EC:1.4.1.13]
synonym: "GOGAT activity" EXACT [EC:1.4.1.13]
synonym: "L-glutamate synthase activity" BROAD [EC:1.4.1.13]
synonym: "L-glutamate synthetase activity" BROAD [EC:1.4.1.13]
synonym: "L-glutamate:NADP+ oxidoreductase (transaminating)" EXACT [EC:1.4.1.13]
synonym: "L-glutamine:2-oxoglutarate aminotransferase, NADPH oxidizing activity" EXACT [EC:1.4.1.13]
synonym: "NADPH-dependent glutamate synthase activity" EXACT [EC:1.4.1.13]
synonym: "NADPH-glutamate synthase activity" EXACT [EC:1.4.1.13]
synonym: "NADPH-linked glutamate synthase" EXACT [EC:1.4.1.13]
xref: EC:1.4.1.13
xref: KEGG:R00114
xref: MetaCyc:GLUGLNSYN-PWY
xref: MetaCyc:GLUTAMATESYN-RXN
xref: MetaCyc:GLUTSYN-PWY
xref: RHEA:15504
is_a: GO:0045181 ! glutamate synthase activity, NAD(P)H as acceptor

[Term]
id: GO:0004356
name: glutamate-ammonia ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamate + ATP + NH(4)(+) = L-glutamine + ADP + 2 H(+) + phosphate." [EC:6.3.1.2, RHEA:16172]
subset: gosubset_prok
synonym: "glutamine synthetase activity" EXACT []
synonym: "glutamylhydroxamic synthetase activity" EXACT [EC:6.3.1.2]
synonym: "L-glutamate:ammonia ligase (ADP-forming)" EXACT [EC:6.3.1.2]
synonym: "L-glutamine synthetase activity" EXACT [EC:6.3.1.2]
xref: EC:6.3.1.2
xref: KEGG:R00253
xref: MetaCyc:GLUTAMINESYN-RXN
xref: Reactome:REACT_104006 "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL], Danio rerio"
xref: Reactome:REACT_104940 "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL], Drosophila melanogaster"
xref: Reactome:REACT_110265 "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL], Gallus gallus"
xref: Reactome:REACT_112105 "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL], Oryza sativa"
xref: Reactome:REACT_115035 "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL], Arabidopsis thaliana"
xref: Reactome:REACT_1171 "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL], Homo sapiens"
xref: Reactome:REACT_28913 "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL], Sus scrofa"
xref: Reactome:REACT_33705 "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL], Canis familiaris"
xref: Reactome:REACT_34384 "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL], Saccharomyces cerevisiae"
xref: Reactome:REACT_39662 "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL], Caenorhabditis elegans"
xref: Reactome:REACT_77424 "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL], Bos taurus"
xref: Reactome:REACT_77661 "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL], Schizosaccharomyces pombe"
xref: Reactome:REACT_86685 "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL], Xenopus tropicalis"
xref: Reactome:REACT_90402 "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL], Mus musculus"
xref: Reactome:REACT_90408 "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL], Taeniopygia guttata"
xref: Reactome:REACT_92620 "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL], Rattus norvegicus"
xref: RHEA:16172
is_a: GO:0016211 ! ammonia ligase activity

[Term]
id: GO:0004357
name: glutamate-cysteine ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H(+) + phosphate." [EC:6.3.2.2, RHEA:13288]
subset: gosubset_prok
synonym: "gamma-glutamyl-L-cysteine synthetase activity" EXACT [EC:6.3.2.2]
synonym: "gamma-glutamylcysteine synthetase activity" EXACT [EC:6.3.2.2]
synonym: "gamma-glutamylcysteinyl synthetase activity" EXACT [EC:6.3.2.2]
synonym: "L-glutamate:L-cysteine gamma-ligase (ADP-forming) activity" EXACT [EC:6.3.2.2]
xref: EC:6.3.2.2
xref: KEGG:R00894
xref: MetaCyc:GLUTCYSLIG-RXN
xref: Reactome:REACT_28974 "Glutamate and cysteine combine, Schizosaccharomyces pombe"
xref: Reactome:REACT_29140 "Glutamate and cysteine combine, Sus scrofa"
xref: Reactome:REACT_30350 "Glutamate and cysteine combine, Mus musculus"
xref: Reactome:REACT_32418 "Glutamate and cysteine combine, Rattus norvegicus"
xref: Reactome:REACT_6970 "Glutamate and cysteine combine, Homo sapiens"
xref: Reactome:REACT_79569 "Glutamate and cysteine combine, Canis familiaris"
xref: Reactome:REACT_82470 "Glutamate and cysteine combine, Xenopus tropicalis"
xref: Reactome:REACT_88007 "Glutamate and cysteine combine, Gallus gallus"
xref: Reactome:REACT_90345 "Glutamate and cysteine combine, Taeniopygia guttata"
xref: Reactome:REACT_91026 "Glutamate and cysteine combine, Danio rerio"
xref: Reactome:REACT_96699 "Glutamate and cysteine combine, Drosophila melanogaster"
xref: Reactome:REACT_99078 "Glutamate and cysteine combine, Caenorhabditis elegans"
xref: RHEA:13288
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0004358
name: glutamate N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N(2)-acetyl-L-ornithine + L-glutamate = N-acetyl-L-glutamate + L-ornithine." [EC:2.3.1.35, RHEA:15352]
subset: gosubset_prok
synonym: "2-N-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity" EXACT [EC:2.3.1.35]
synonym: "acetylglutamate synthetase activity" EXACT [EC:2.3.1.35]
synonym: "acetylglutamate-acetylornithine transacetylase activity" EXACT [EC:2.3.1.35]
synonym: "acetylglutamic synthetase activity" EXACT [EC:2.3.1.35]
synonym: "acetylglutamic-acetylornithine transacetylase activity" EXACT [EC:2.3.1.35]
synonym: "acetylornithinase activity" BROAD [EC:2.3.1.35]
synonym: "acetylornithine glutamate acetyltransferase activity" EXACT [EC:2.3.1.35]
synonym: "alpha-N-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity" EXACT [EC:2.3.1.35]
synonym: "glutamate acetyltransferase activity" EXACT [EC:2.3.1.35]
synonym: "N-acetyl-L-glutamate synthetase activity" BROAD [EC:2.3.1.35]
synonym: "N-acetylglutamate synthase activity" BROAD [EC:2.3.1.35]
synonym: "N-acetylglutamate synthetase activity" BROAD [EC:2.3.1.35]
synonym: "N2-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity" EXACT [EC:2.3.1.35]
synonym: "ornithine acetyltransferase activity" EXACT [EC:2.3.1.35]
synonym: "ornithine transacetylase activity" EXACT [EC:2.3.1.35]
xref: EC:2.3.1.35
xref: KEGG:R02282
xref: MetaCyc:GLUTAMATE-N-ACETYLTRANSFERASE-RXN
xref: RHEA:15352
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0004359
name: glutaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH3." [EC:3.5.1.2]
subset: gosubset_prok
synonym: "glutaminase I" RELATED [EC:3.5.1.2]
synonym: "glutamine aminohydrolase activity" EXACT [EC:3.5.1.2]
synonym: "L-glutaminase activity" EXACT [EC:3.5.1.2]
synonym: "L-glutamine amidohydrolase activity" EXACT [EC:3.5.1.2]
xref: EC:3.5.1.2
xref: MetaCyc:GLUTAMIN-RXN
xref: Reactome:REACT_101863 "glutamine + H2O => glutamate + NH4+ [GLS], Rattus norvegicus"
xref: Reactome:REACT_108874 "glutamine + H2O => glutamate + NH4+ [GLS], Bos taurus"
xref: Reactome:REACT_1700 "glutamine + H2O => glutamate + NH4+ [GLS], Homo sapiens"
xref: Reactome:REACT_30789 "glutamine + H2O => glutamate + NH4+ [GLS], Drosophila melanogaster"
xref: Reactome:REACT_40104 "glutamine + H2O => glutamate + NH4+ [GLS], Gallus gallus"
xref: Reactome:REACT_81929 "glutamine + H2O => glutamate + NH4+ [GLS], Escherichia coli"
xref: Reactome:REACT_82434 "glutamine + H2O => glutamate + NH4+ [GLS], Canis familiaris"
xref: Reactome:REACT_84071 "glutamine + H2O => glutamate + NH4+ [GLS], Mus musculus"
xref: Reactome:REACT_91801 "glutamine + H2O => glutamate + NH4+ [GLS], Caenorhabditis elegans"
xref: Reactome:REACT_94730 "glutamine + H2O => glutamate + NH4+ [GLS], Xenopus tropicalis"
xref: Reactome:REACT_97500 "glutamine + H2O => glutamate + NH4+ [GLS], Danio rerio"
xref: Reactome:REACT_98074 "glutamine + H2O => glutamate + NH4+ [GLS], Sus scrofa"
xref: Reactome:REACT_98880 "glutamine + H2O => glutamate + NH4+ [GLS], Taeniopygia guttata"
xref: RHEA:15892
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0004360
name: glutamine-fructose-6-phosphate transaminase (isomerizing) activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate." [EC:2.6.1.16, RHEA:13240]
subset: gosubset_prok
synonym: "D-fructose-6-phosphate amidotransferase activity" EXACT [EC:2.6.1.16]
synonym: "GlcN6P synthase activity" EXACT [EC:2.6.1.16]
synonym: "glucosamine 6-phosphate synthase activity" EXACT [EC:2.6.1.16]
synonym: "glucosamine--fructose-6-phosphate aminotransferase (isomerizing) activity" EXACT [EC:2.6.1.16]
synonym: "glucosamine-6-phosphate isomerase (glutamine-forming) activity" EXACT []
synonym: "glucosamine-6-phosphate synthase activity" EXACT [EC:2.6.1.16]
synonym: "glucosaminephosphate isomerase" BROAD [EC:2.6.1.16]
synonym: "hexosephosphate aminotransferase activity" EXACT [EC:2.6.1.16]
synonym: "L-glutamine-D-fructose-6-phosphate amidotransferase activity" EXACT [EC:2.6.1.16]
synonym: "L-glutamine:D-fructose-6-phosphate isomerase (deaminating)" EXACT [EC:2.6.1.16]
xref: EC:2.6.1.16
xref: KEGG:R00768
xref: MetaCyc:L-GLN-FRUCT-6-P-AMINOTRANS-RXN
xref: Reactome:REACT_22115 "Formation of glucosamine 6-phosphate from fructose 6-phosphate and glutamine, Homo sapiens"
xref: RHEA:13240
is_a: GO:0070548 ! L-glutamine aminotransferase activity

[Term]
id: GO:0004361
name: glutaryl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor." [EC:1.3.99.7]
subset: gosubset_prok
synonym: "glutaryl coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.7]
synonym: "glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating)" EXACT [EC:1.3.99.7]
synonym: "glutaryl-CoA:acceptor 2,3-oxidoreductase (decarboxylating)" EXACT [EC:1.3.99.7]
xref: EC:1.3.99.7
xref: MetaCyc:GLUTARYL-COA-DEHYDROGENASE-RXN
xref: Reactome:REACT_108443 "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2, Staphylococcus aureus N315"
xref: Reactome:REACT_110967 "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2, Sus scrofa"
xref: Reactome:REACT_1409 "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2, Homo sapiens"
xref: Reactome:REACT_29149 "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2, Arabidopsis thaliana"
xref: Reactome:REACT_79092 "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2, Canis familiaris"
xref: Reactome:REACT_87295 "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2, Xenopus tropicalis"
xref: Reactome:REACT_93502 "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2, Mus musculus"
xref: Reactome:REACT_93650 "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2, Mycobacterium tuberculosis"
xref: Reactome:REACT_94738 "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2, Danio rerio"
xref: Reactome:REACT_94848 "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2, Rattus norvegicus"
xref: Reactome:REACT_96762 "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2, Caenorhabditis elegans"
xref: Reactome:REACT_96865 "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2, Bos taurus"
xref: Reactome:REACT_97682 "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2, Drosophila melanogaster"
xref: Reactome:REACT_98305 "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2, Dictyostelium discoideum"
xref: RHEA:13392
xref: UM-BBD_reactionID:r0198
is_a: GO:0003995 ! acyl-CoA dehydrogenase activity

[Term]
id: GO:0004362
name: glutathione-disulfide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+." [EC:1.8.1.7, ISBN:0198506732]
comment: Note that this function was formerly EC:1.6.4.2.
subset: gosubset_prok
synonym: "glutathione reductase (NADPH) activity" EXACT []
synonym: "glutathione reductase activity" EXACT []
synonym: "glutathione S-reductase activity" EXACT [EC:1.8.1.7]
synonym: "glutathione-disulphide reductase activity" EXACT []
synonym: "glutathione:NADP+ oxidoreductase activity" EXACT [EC:1.8.1.7]
synonym: "GSH reductase activity" EXACT [EC:1.8.1.7]
synonym: "GSSG reductase activity" EXACT [EC:1.8.1.7]
synonym: "NADPH-glutathione reductase activity" EXACT [EC:1.8.1.7]
synonym: "NADPH-GSSG reductase activity" EXACT [EC:1.8.1.7]
synonym: "NADPH:oxidized-glutathione oxidoreductase activity" EXACT [EC:1.8.1.7]
synonym: "oxidized glutathione reduction" RELATED []
xref: EC:1.8.1.7
xref: MetaCyc:GLUTATHIONE-REDUCT-NADPH-RXN
xref: Reactome:REACT_100755 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+, Plasmodium falciparum"
xref: Reactome:REACT_105351 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+, Mus musculus"
xref: Reactome:REACT_106052 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+, Escherichia coli"
xref: Reactome:REACT_107331 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+, Bos taurus"
xref: Reactome:REACT_108894 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+, Xenopus tropicalis"
xref: Reactome:REACT_2220 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+, Homo sapiens"
xref: Reactome:REACT_31135 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+, Canis familiaris"
xref: Reactome:REACT_33636 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+, Sus scrofa"
xref: Reactome:REACT_34766 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+, Dictyostelium discoideum"
xref: Reactome:REACT_82516 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+, Rattus norvegicus"
xref: Reactome:REACT_87466 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+, Mycobacterium tuberculosis"
xref: Reactome:REACT_91212 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+, Schizosaccharomyces pombe"
xref: Reactome:REACT_91373 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+, Danio rerio"
xref: Reactome:REACT_93897 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+, Caenorhabditis elegans"
xref: Reactome:REACT_95299 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+, Saccharomyces cerevisiae"
xref: Reactome:REACT_95410 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+, Gallus gallus"
xref: Reactome:REACT_98360 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+, Taeniopygia guttata"
xref: RHEA:11743
is_a: GO:0015038 ! glutathione disulfide oxidoreductase activity
is_a: GO:0016209 ! antioxidant activity
is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor

[Term]
id: GO:0004363
name: glutathione synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H(+) + phosphate." [EC:6.3.2.3, RHEA:13560]
subset: gosubset_prok
synonym: "gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)" EXACT [EC:6.3.2.3]
synonym: "glutathione synthetase activity" EXACT [EC:6.3.2.3]
synonym: "GSH synthetase activity" EXACT [EC:6.3.2.3]
xref: EC:6.3.2.3
xref: KEGG:R00497
xref: MetaCyc:GLUTATHIONE-SYN-RXN
xref: Reactome:REACT_100394 "gamma-glutamylcysteine combines with glycine to form glutathione, Caenorhabditis elegans"
xref: Reactome:REACT_104397 "gamma-glutamylcysteine combines with glycine to form glutathione, Saccharomyces cerevisiae"
xref: Reactome:REACT_105605 "gamma-glutamylcysteine combines with glycine to form glutathione, Bos taurus"
xref: Reactome:REACT_105891 "gamma-glutamylcysteine combines with glycine to form glutathione, Taeniopygia guttata"
xref: Reactome:REACT_108106 "gamma-glutamylcysteine combines with glycine to form glutathione, Sus scrofa"
xref: Reactome:REACT_108848 "gamma-glutamylcysteine combines with glycine to form glutathione, Rattus norvegicus"
xref: Reactome:REACT_6886 "gamma-glutamylcysteine combines with glycine to form glutathione, Homo sapiens"
xref: Reactome:REACT_80709 "gamma-glutamylcysteine combines with glycine to form glutathione, Arabidopsis thaliana"
xref: Reactome:REACT_81099 "gamma-glutamylcysteine combines with glycine to form glutathione, Canis familiaris"
xref: Reactome:REACT_82957 "gamma-glutamylcysteine combines with glycine to form glutathione, Drosophila melanogaster"
xref: Reactome:REACT_84994 "gamma-glutamylcysteine combines with glycine to form glutathione, Mus musculus"
xref: Reactome:REACT_86625 "gamma-glutamylcysteine combines with glycine to form glutathione, Schizosaccharomyces pombe"
xref: Reactome:REACT_86921 "gamma-glutamylcysteine combines with glycine to form glutathione, Oryza sativa"
xref: Reactome:REACT_87951 "gamma-glutamylcysteine combines with glycine to form glutathione, Xenopus tropicalis"
xref: Reactome:REACT_90100 "gamma-glutamylcysteine combines with glycine to form glutathione, Dictyostelium discoideum"
xref: Reactome:REACT_93797 "gamma-glutamylcysteine combines with glycine to form glutathione, Gallus gallus"
xref: Reactome:REACT_99493 "gamma-glutamylcysteine combines with glycine to form glutathione, Danio rerio"
xref: Reactome:REACT_99980 "gamma-glutamylcysteine combines with glycine to form glutathione, Plasmodium falciparum"
xref: RHEA:13560
is_a: GO:0016881 ! acid-amino acid ligase activity
relationship: part_of GO:0006750 ! glutathione biosynthetic process

[Term]
id: GO:0004364
name: glutathione transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18]
subset: gosubset_prok
synonym: "glutathione conjugation reaction" EXACT []
synonym: "glutathione S-alkyl transferase activity" EXACT [EC:2.5.1.18]
synonym: "glutathione S-alkyltransferase activity" EXACT [EC:2.5.1.18]
synonym: "glutathione S-aralkyltransferase activity" EXACT [EC:2.5.1.18]
synonym: "glutathione S-aryltransferase activity" EXACT [EC:2.5.1.18]
synonym: "glutathione S-transferase activity" EXACT [EC:2.5.1.18]
synonym: "RX:glutathione R-transferase activity" EXACT [EC:2.5.1.18]
synonym: "S-(hydroxyalkyl)glutathione lyase activity" EXACT [EC:2.5.1.18]
xref: EC:2.5.1.18
xref: MetaCyc:GSHTRAN-RXN
xref: Reactome:REACT_100785 "Glutathione conjugation of luminal substrates, Oryza sativa"
xref: Reactome:REACT_101029 "Glutathione conjugation of luminal substrates, Canis familiaris"
xref: Reactome:REACT_108390 "Glutathione conjugation of luminal substrates, Gallus gallus"
xref: Reactome:REACT_110631 "Glutathione conjugation of luminal substrates, Xenopus tropicalis"
xref: Reactome:REACT_113981 "Glutathione conjugation of cytosolic substrates, Oryza sativa"
xref: Reactome:REACT_114178 "Glutathione conjugation of luminal substrates, Plasmodium falciparum"
xref: Reactome:REACT_114437 "Glutathione conjugation of cytosolic substrates, Arabidopsis thaliana"
xref: Reactome:REACT_114776 "Glutathione conjugation of cytosolic substrates, Plasmodium falciparum"
xref: Reactome:REACT_30282 "Glutathione conjugation of cytosolic substrates, Canis familiaris"
xref: Reactome:REACT_32347 "Glutathione conjugation of cytosolic substrates, Sus scrofa"
xref: Reactome:REACT_6854 "Glutathione conjugation of cytosolic substrates, Homo sapiens"
xref: Reactome:REACT_6947 "Glutathione conjugation of luminal substrates, Homo sapiens"
xref: Reactome:REACT_78100 "Glutathione conjugation of cytosolic substrates, Caenorhabditis elegans"
xref: Reactome:REACT_78483 "Glutathione conjugation of cytosolic substrates, Gallus gallus"
xref: Reactome:REACT_80590 "Glutathione conjugation of cytosolic substrates, Taeniopygia guttata"
xref: Reactome:REACT_83452 "Glutathione conjugation of luminal substrates, Sus scrofa"
xref: Reactome:REACT_84786 "Glutathione conjugation of cytosolic substrates, Danio rerio"
xref: Reactome:REACT_84896 "Glutathione conjugation of cytosolic substrates, Xenopus tropicalis"
xref: Reactome:REACT_85283 "Glutathione conjugation of cytosolic substrates, Mus musculus"
xref: Reactome:REACT_85369 "Glutathione conjugation of cytosolic substrates, Rattus norvegicus"
xref: Reactome:REACT_87985 "Glutathione conjugation of luminal substrates, Bos taurus"
xref: Reactome:REACT_89910 "Glutathione conjugation of cytosolic substrates, Drosophila melanogaster"
xref: Reactome:REACT_92411 "Glutathione conjugation of luminal substrates, Arabidopsis thaliana"
xref: Reactome:REACT_93234 "Glutathione conjugation of luminal substrates, Rattus norvegicus"
xref: Reactome:REACT_93830 "Glutathione conjugation of luminal substrates, Danio rerio"
xref: Reactome:REACT_94550 "Glutathione conjugation of cytosolic substrates, Bos taurus"
xref: Reactome:REACT_97954 "Glutathione conjugation of luminal substrates, Mus musculus"
xref: Reactome:REACT_98524 "Glutathione conjugation of luminal substrates, Drosophila melanogaster"
xref: Reactome:REACT_99142 "Glutathione conjugation of luminal substrates, Taeniopygia guttata"
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0004365
name: glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+." [EC:1.2.1.12]
subset: gosubset_prok
synonym: "3-phosphoglyceraldehyde dehydrogenase activity" EXACT [EC:1.2.1.12]
synonym: "D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating)" EXACT [EC:1.2.1.12]
synonym: "dehydrogenase, glyceraldehyde phosphate" EXACT [EC:1.2.1.12]
synonym: "GAPDH activity" EXACT [EC:1.2.1.12]
synonym: "glyceraldehyde phosphate dehydrogenase (NAD)" EXACT [EC:1.2.1.12]
synonym: "glyceraldehyde-3-P-dehydrogenase activity" EXACT [EC:1.2.1.12]
synonym: "NAD-dependent glyceraldehyde phosphate dehydrogenase activity" EXACT [EC:1.2.1.12]
synonym: "NAD-dependent glyceraldehyde-3-phosphate dehydrogenase activity" EXACT [EC:1.2.1.12]
synonym: "NADH-glyceraldehyde phosphate dehydrogenase activity" EXACT [EC:1.2.1.12]
synonym: "phosphoglyceraldehyde dehydrogenase activity" EXACT [EC:1.2.1.12]
synonym: "triosephosphate dehydrogenase activity" BROAD [EC:1.2.1.12]
xref: EC:1.2.1.12
xref: MetaCyc:GAPOXNPHOSPHN-RXN
xref: Reactome:REACT_100096 "1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+, Rattus norvegicus"
xref: Reactome:REACT_100121 "1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+, Dictyostelium discoideum"
xref: Reactome:REACT_101212 "1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+, Gallus gallus"
xref: Reactome:REACT_103017 "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+, Sus scrofa"
xref: Reactome:REACT_103197 "1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+, Bos taurus"
xref: Reactome:REACT_103214 "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+, Mus musculus"
xref: Reactome:REACT_104299 "1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+, Sus scrofa"
xref: Reactome:REACT_105091 "1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+, Taeniopygia guttata"
xref: Reactome:REACT_106850 "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+, Taeniopygia guttata"
xref: Reactome:REACT_112334 "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+, Oryza sativa"
xref: Reactome:REACT_112690 "1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+, Drosophila melanogaster"
xref: Reactome:REACT_112805 "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+, Arabidopsis thaliana"
xref: Reactome:REACT_113461 "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+, Drosophila melanogaster"
xref: Reactome:REACT_113644 "1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+, Xenopus tropicalis"
xref: Reactome:REACT_113850 "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+, Plasmodium falciparum"
xref: Reactome:REACT_114520 "1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+, Plasmodium falciparum"
xref: Reactome:REACT_115033 "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+, Xenopus tropicalis"
xref: Reactome:REACT_115268 "1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+, Oryza sativa"
xref: Reactome:REACT_115436 "1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+, Arabidopsis thaliana"
xref: Reactome:REACT_115700 "glyceraldehyde 3-phosphate + NAD+ + phosphate <=> 1,3-bisphosphoglycerate + NADH + H+, Gallus gallus"
xref: Reactome:REACT_115940 "1,3-bisphosphoglycerate + NADH + H+ <=> glyceraldehyde 3-phosphate + NAD+ + phosphate, Gallus gallus"
xref: Reactome:REACT_1593 "1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+, Homo sapiens"
xref: Reactome:REACT_1847 "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+, Homo sapiens"
xref: Reactome:REACT_28184 "1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+, Mus musculus"
xref: Reactome:REACT_32076 "1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+, Escherichia coli"
xref: Reactome:REACT_32485 "1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+, Caenorhabditis elegans"
xref: Reactome:REACT_77380 "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+, Danio rerio"
xref: Reactome:REACT_80434 "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+, Dictyostelium discoideum"
xref: Reactome:REACT_80815 "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+, Caenorhabditis elegans"
xref: Reactome:REACT_83464 "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+, Schizosaccharomyces pombe"
xref: Reactome:REACT_85937 "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+, Rattus norvegicus"
xref: Reactome:REACT_87656 "1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+, Danio rerio"
xref: Reactome:REACT_89732 "1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+, Canis familiaris"
xref: Reactome:REACT_93301 "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+, Gallus gallus"
xref: Reactome:REACT_95562 "1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+, Schizosaccharomyces pombe"
xref: Reactome:REACT_98283 "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+, Canis familiaris"
xref: Reactome:REACT_99054 "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+, Escherichia coli"
xref: Reactome:REACT_99793 "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+, Bos taurus"
xref: RHEA:10303
is_a: GO:0043891 ! glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity

[Term]
id: GO:0004366
name: glycerol-3-phosphate O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate." [EC:2.3.1.15]
subset: gosubset_prok
synonym: "3-glycerophosphate acyltransferase activity" EXACT [EC:2.3.1.15]
synonym: "ACP:sn-glycerol-3-phosphate acyltransferase activity" EXACT [EC:2.3.1.15]
synonym: "acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase activity" EXACT [EC:2.3.1.15]
synonym: "alpha-glycerophosphate acyltransferase activity" EXACT [EC:2.3.1.15]
synonym: "glycerol 3-phosphate acyltransferase activity" EXACT [EC:2.3.1.15]
synonym: "glycerol phosphate acyltransferase activity" EXACT [EC:2.3.1.15]
synonym: "glycerol phosphate transacylase activity" EXACT [EC:2.3.1.15]
synonym: "glycerophosphate acyltransferase activity" EXACT [EC:2.3.1.15]
synonym: "glycerophosphate transacylase activity" EXACT [EC:2.3.1.15]
synonym: "sn-glycerol 3-phosphate acyltransferase activity" EXACT [EC:2.3.1.15]
synonym: "sn-glycerol-3-phosphate acyltransferase activity" EXACT [EC:2.3.1.15]
xref: EC:2.3.1.15
xref: MetaCyc:RXN-1381
xref: Reactome:REACT_102260 "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [ER membrane-associated], Canis familiaris"
xref: Reactome:REACT_103249 "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated], Danio rerio"
xref: Reactome:REACT_104688 "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [ER membrane-associated], Rattus norvegicus"
xref: Reactome:REACT_105427 "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [ER membrane-associated], Oryza sativa"
xref: Reactome:REACT_106143 "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [ER membrane-associated], Xenopus tropicalis"
xref: Reactome:REACT_106172 "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated], Canis familiaris"
xref: Reactome:REACT_109516 "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated], Taeniopygia guttata"
xref: Reactome:REACT_110268 "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [ER membrane-associated], Drosophila melanogaster"
xref: Reactome:REACT_112568 "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated], Escherichia coli"
xref: Reactome:REACT_113073 "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated], Mycobacterium tuberculosis"
xref: Reactome:REACT_114086 "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [ER membrane-associated], Arabidopsis thaliana"
xref: Reactome:REACT_114724 "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [ER membrane-associated], Dictyostelium discoideum"
xref: Reactome:REACT_22419 "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [ER membrane-associated], Homo sapiens"
xref: Reactome:REACT_28205 "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [ER membrane-associated], Caenorhabditis elegans"
xref: Reactome:REACT_29766 "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated], Mus musculus"
xref: Reactome:REACT_31766 "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [ER membrane-associated], Bos taurus"
xref: Reactome:REACT_32967 "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [ER membrane-associated], Sus scrofa"
xref: Reactome:REACT_64502 "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated], Bos taurus"
xref: Reactome:REACT_78811 "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [ER membrane-associated], Taeniopygia guttata"
xref: Reactome:REACT_80589 "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated], Drosophila melanogaster"
xref: Reactome:REACT_81620 "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [ER membrane-associated], Gallus gallus"
xref: Reactome:REACT_839 "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated], Homo sapiens"
xref: Reactome:REACT_84188 "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated], Gallus gallus"
xref: Reactome:REACT_85896 "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [ER membrane-associated], Danio rerio"
xref: Reactome:REACT_87756 "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated], Sus scrofa"
xref: Reactome:REACT_93755 "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated], Caenorhabditis elegans"
xref: Reactome:REACT_94514 "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [ER membrane-associated], Mus musculus"
xref: Reactome:REACT_96423 "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated], Rattus norvegicus"
xref: RHEA:15328
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0004367
name: glycerol-3-phosphate dehydrogenase [NAD+] activity
namespace: molecular_function
def: "Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+." [EC:1.1.1.8, EC:1.1.1.94]
subset: gosubset_prok
synonym: "alpha-glycerol phosphate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.8]
synonym: "alpha-glycerophosphate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.8]
synonym: "glycerol 1-phosphate dehydrogenase activity" RELATED [EC:1.1.1.8]
synonym: "glycerol phosphate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.8]
synonym: "glycerol-3-phosphate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.8]
synonym: "glycerophosphate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.8]
synonym: "hydroglycerophosphate dehydrogenase activity" BROAD [EC:1.1.1.8]
synonym: "L-alpha-glycerol phosphate dehydrogenase activity" BROAD [EC:1.1.1.8]
synonym: "L-alpha-glycerophosphate dehydrogenase activity" BROAD [EC:1.1.1.8]
synonym: "L-glycerol phosphate dehydrogenase activity" BROAD [EC:1.1.1.8]
synonym: "L-glycerophosphate dehydrogenase activity" BROAD [EC:1.1.1.8]
synonym: "NAD-alpha-glycerophosphate dehydrogenase activity" EXACT [EC:1.1.1.8]
synonym: "NAD-dependent glycerol phosphate dehydrogenase activity" EXACT [EC:1.1.1.8]
synonym: "NAD-dependent glycerol-3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.8]
synonym: "NAD-L-glycerol-3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.8]
synonym: "NAD-linked glycerol 3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.8]
synonym: "NADH-dihydroxyacetone phosphate reductase activity" RELATED [EC:1.1.1.8]
xref: EC:1.1.1.8
xref: EC:1.1.1.94
xref: KEGG:R00842
xref: MetaCyc:1.1.1.8-RXN
xref: Reactome:REACT_102291 "Conversion of Dihydroxyacetone Phosphate to Glycerol -3- phosphate, Bos taurus"
xref: Reactome:REACT_102745 "Conversion of Dihydroxyacetone Phosphate to Glycerol -3- phosphate, Sus scrofa"
xref: Reactome:REACT_109811 "Conversion of Dihydroxyacetone Phosphate to Glycerol -3- phosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_110408 "Conversion of Dihydroxyacetone Phosphate to Glycerol -3- phosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_113156 "Conversion of Dihydroxyacetone Phosphate to Glycerol -3- phosphate, Danio rerio"
xref: Reactome:REACT_1146 "Conversion of Dihydroxyacetone Phosphate to Glycerol -3- phosphate, Homo sapiens"
xref: Reactome:REACT_115427 "Conversion of Dihydroxyacetone Phosphate to Glycerol -3- phosphate, Caenorhabditis elegans"
xref: Reactome:REACT_28453 "Conversion of Dihydroxyacetone Phosphate to Glycerol -3- phosphate, Rattus norvegicus"
xref: Reactome:REACT_33169 "Conversion of Dihydroxyacetone Phosphate to Glycerol -3- phosphate, Taeniopygia guttata"
xref: Reactome:REACT_79475 "Conversion of Dihydroxyacetone Phosphate to Glycerol -3- phosphate, Xenopus tropicalis"
xref: Reactome:REACT_95798 "Conversion of Dihydroxyacetone Phosphate to Glycerol -3- phosphate, Canis familiaris"
xref: Reactome:REACT_96371 "Conversion of Dihydroxyacetone Phosphate to Glycerol -3- phosphate, Mus musculus"
xref: RHEA:11095
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004368
name: glycerol-3-phosphate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol." [EC:1.1.5.3]
comment: Note that enzymes classified as EC:1.1.5.3 have several activities. They should be annotated with the terms GO:0004368, GO:0052590 and GO:0052591.
subset: gosubset_prok
synonym: "FAD-dependent glycerol-3-phosphate dehydrogenase" EXACT [EC:1.1.5.3]
synonym: "flavin-linked glycerol-3-phosphate dehydrogenase" EXACT [EC:1.1.5.3]
synonym: "glycerol-3-phosphate CoQ reductase" EXACT [EC:1.1.5.3]
synonym: "glycerophosphate dehydrogenase activity" EXACT [EC:1.1.5.3]
synonym: "L-glycerophosphate dehydrogenase activity" EXACT [EC:1.1.5.3]
synonym: "sn-glycerol-3-phosphate dehydrogenase activity" EXACT [EC:1.1.5.3]
synonym: "sn-glycerol-3-phosphate:quinone oxidoreductase activity" EXACT systematic_synonym [EC:1.1.5.3]
xref: EC:1.1.5.3
xref: MetaCyc:RXN-9927
xref: MetaCyc:RXN0-5260
xref: Reactome:REACT_100144 "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase), Danio rerio"
xref: Reactome:REACT_100249 "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase), Staphylococcus aureus N315"
xref: Reactome:REACT_102204 "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase), Plasmodium falciparum"
xref: Reactome:REACT_104083 "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase), Saccharomyces cerevisiae"
xref: Reactome:REACT_104648 "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase), Gallus gallus"
xref: Reactome:REACT_112809 "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase), Mycobacterium tuberculosis"
xref: Reactome:REACT_114651 "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase), Caenorhabditis elegans"
xref: Reactome:REACT_115394 "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase), Drosophila melanogaster"
xref: Reactome:REACT_16938 "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase), Homo sapiens"
xref: Reactome:REACT_29747 "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase), Oryza sativa"
xref: Reactome:REACT_31546 "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase), Escherichia coli"
xref: Reactome:REACT_32782 "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase), Rattus norvegicus"
xref: Reactome:REACT_74143 "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase), Canis familiaris"
xref: Reactome:REACT_77515 "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase), Schizosaccharomyces pombe"
xref: Reactome:REACT_80640 "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase), Dictyostelium discoideum"
xref: Reactome:REACT_81759 "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase), Bos taurus"
xref: Reactome:REACT_88257 "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase), Arabidopsis thaliana"
xref: Reactome:REACT_90197 "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase), Xenopus tropicalis"
xref: Reactome:REACT_90540 "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase), Taeniopygia guttata"
xref: Reactome:REACT_92766 "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase), Sus scrofa"
xref: Reactome:REACT_99928 "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase), Mus musculus"
xref: RHEA:18980
is_a: GO:0016901 ! oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor

[Term]
id: GO:0004369
name: glycerol-3-phosphate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: sn-glycerol 3-phosphate + O(2) = glycerone phosphate + H(2)O(2)." [EC:1.1.3.21, RHEA:18372]
subset: gosubset_prok
synonym: "alpha-glycerophosphate oxidase activity" EXACT [EC:1.1.3.21]
synonym: "glycerol phosphate oxidase activity" EXACT [EC:1.1.3.21]
synonym: "glycerol-1-phosphate oxidase activity" EXACT [EC:1.1.3.21]
synonym: "L-alpha-glycerol-3-phosphate oxidase activity" EXACT [EC:1.1.3.21]
synonym: "L-alpha-glycerophosphate oxidase activity" EXACT [EC:1.1.3.21]
synonym: "sn-glycerol-3-phosphate:oxygen 2-oxidoreductase activity" EXACT [EC:1.1.3.21]
xref: EC:1.1.3.21
xref: KEGG:R00846
xref: MetaCyc:GLYCEROL-3-PHOSPHATE-OXIDASE-RXN
xref: RHEA:18372
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0004370
name: glycerol kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + glycerol = sn-glycerol 3-phosphate + ADP + 2 H(+)." [EC:2.7.1.30, RHEA:21647]
subset: gosubset_prok
synonym: "ATP:glycerol 3-phosphotransferase activity" EXACT [EC:2.7.1.30]
synonym: "ATP:glycerol-3-phosphotransferase activity" EXACT [EC:2.7.1.30]
synonym: "GK" RELATED [EC:2.7.1.30]
synonym: "glyceric kinase activity" EXACT [EC:2.7.1.30]
synonym: "glycerokinase activity" EXACT [EC:2.7.1.30]
synonym: "glycerol kinase (phosphorylating)" EXACT [EC:2.7.1.30]
xref: EC:2.7.1.30
xref: KEGG:R00847
xref: MetaCyc:GLYCEROL-KIN-RXN
xref: Reactome:REACT_724 "Conversion of Glycerol to Glycerol-3-phosphate, Homo sapiens"
xref: RHEA:21647
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0004371
name: glycerone kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate + 2 H(+)." [EC:2.7.1.29, RHEA:15776]
subset: gosubset_prok
synonym: "acetol kinase (phosphorylating)" EXACT [EC:2.7.1.29]
synonym: "acetol kinase activity" EXACT [EC:2.7.1.29]
synonym: "ATP:glycerone phosphotransferase activity" EXACT [EC:2.7.1.29]
synonym: "dihydroxyacetone kinase activity" EXACT [EC:2.7.1.29]
xref: EC:2.7.1.29
xref: KEGG:R01011
xref: MetaCyc:GLYCERONE-KINASE-RXN
xref: RHEA:15776
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0004372
name: glycine hydroxymethyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine." [EC:2.1.2.1]
subset: gosubset_prok
synonym: "5,10-methylenetetrahydrofolate:glycine hydroxymethyltransferase activity" EXACT [EC:2.1.2.1]
synonym: "allothreonine aldolase activity" EXACT [EC:2.1.2.1]
synonym: "L-serine hydroxymethyltransferase activity" EXACT [EC:2.1.2.1]
synonym: "serine aldolase activity" EXACT [EC:2.1.2.1]
synonym: "serine hydroxymethylase activity" EXACT [EC:2.1.2.1]
synonym: "serine hydroxymethyltransferase activity" EXACT [EC:2.1.2.1]
synonym: "serine transhydroxymethylase activity" EXACT [EC:2.1.2.1]
xref: EC:2.1.2.1
xref: MetaCyc:GLYOHMETRANS-RXN
xref: Reactome:REACT_100551 "Tetrahydrofolate polyglutamate (THF polyglutamate) + serine <=> 5,10-methyleneTHF polyglutamate + glycine, Taeniopygia guttata"
xref: Reactome:REACT_101143 "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine, Canis familiaris"
xref: Reactome:REACT_103730 "Tetrahydrofolate polyglutamate (THF polyglutamate) + serine <=> 5,10-methyleneTHF polyglutamate + glycine, Oryza sativa"
xref: Reactome:REACT_104026 "beta-hydroxy-trimethyllysine => gamma-butyrobetaine aldehyde + glycine, Plasmodium falciparum"
xref: Reactome:REACT_105838 "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine, Danio rerio"
xref: Reactome:REACT_106100 "Tetrahydrofolate polyglutamate (THF polyglutamate) + serine <=> 5,10-methyleneTHF polyglutamate + glycine, Gallus gallus"
xref: Reactome:REACT_106938 "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine, Taeniopygia guttata"
xref: Reactome:REACT_108889 "beta-hydroxy-trimethyllysine => gamma-butyrobetaine aldehyde + glycine, Taeniopygia guttata"
xref: Reactome:REACT_109080 "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine, Oryza sativa"
xref: Reactome:REACT_110497 "beta-hydroxy-trimethyllysine => gamma-butyrobetaine aldehyde + glycine, Saccharomyces cerevisiae"
xref: Reactome:REACT_110666 "Tetrahydrofolate polyglutamate (THF polyglutamate) + serine <=> 5,10-methyleneTHF polyglutamate + glycine, Arabidopsis thaliana"
xref: Reactome:REACT_110712 "Tetrahydrofolate polyglutamate (THF polyglutamate) + serine <=> 5,10-methyleneTHF polyglutamate + glycine, Xenopus tropicalis"
xref: Reactome:REACT_110780 "beta-hydroxy-trimethyllysine => gamma-butyrobetaine aldehyde + glycine, Mus musculus"
xref: Reactome:REACT_111007 "Tetrahydrofolate polyglutamate (THF polyglutamate) + serine <=> 5,10-methyleneTHF polyglutamate + glycine, Plasmodium falciparum"
xref: Reactome:REACT_11108 "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine, Homo sapiens"
xref: Reactome:REACT_11159 "Tetrahydrofolate polyglutamate (THF polyglutamate) + serine <=> 5,10-methyleneTHF polyglutamate + glycine, Homo sapiens"
xref: Reactome:REACT_112625 "beta-hydroxy-trimethyllysine => gamma-butyrobetaine aldehyde + glycine, Mycobacterium tuberculosis"
xref: Reactome:REACT_112714 "Tetrahydrofolate polyglutamate (THF polyglutamate) + serine <=> 5,10-methyleneTHF polyglutamate + glycine, Staphylococcus aureus N315"
xref: Reactome:REACT_113302 "beta-hydroxy-trimethyllysine => gamma-butyrobetaine aldehyde + glycine, Escherichia coli"
xref: Reactome:REACT_113467 "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine, Escherichia coli"
xref: Reactome:REACT_114244 "Tetrahydrofolate polyglutamate (THF polyglutamate) + serine <=> 5,10-methyleneTHF polyglutamate + glycine, Escherichia coli"
xref: Reactome:REACT_114305 "beta-hydroxy-trimethyllysine => gamma-butyrobetaine aldehyde + glycine, Staphylococcus aureus N315"
xref: Reactome:REACT_114385 "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine, Staphylococcus aureus N315"
xref: Reactome:REACT_114576 "Tetrahydrofolate polyglutamate (THF polyglutamate) + serine <=> 5,10-methyleneTHF polyglutamate + glycine, Mycobacterium tuberculosis"
xref: Reactome:REACT_115121 "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine, Mycobacterium tuberculosis"
xref: Reactome:REACT_1345 "beta-hydroxy-trimethyllysine => gamma-butyrobetaine aldehyde + glycine, Homo sapiens"
xref: Reactome:REACT_30943 "Tetrahydrofolate polyglutamate (THF polyglutamate) + serine <=> 5,10-methyleneTHF polyglutamate + glycine, Drosophila melanogaster"
xref: Reactome:REACT_31482 "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine, Gallus gallus"
xref: Reactome:REACT_31564 "Tetrahydrofolate polyglutamate (THF polyglutamate) + serine <=> 5,10-methyleneTHF polyglutamate + glycine, Rattus norvegicus"
xref: Reactome:REACT_31591 "beta-hydroxy-trimethyllysine => gamma-butyrobetaine aldehyde + glycine, Rattus norvegicus"
xref: Reactome:REACT_33927 "Tetrahydrofolate polyglutamate (THF polyglutamate) + serine <=> 5,10-methyleneTHF polyglutamate + glycine, Mus musculus"
xref: Reactome:REACT_33932 "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine, Plasmodium falciparum"
xref: Reactome:REACT_34223 "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine, Saccharomyces cerevisiae"
xref: Reactome:REACT_77050 "beta-hydroxy-trimethyllysine => gamma-butyrobetaine aldehyde + glycine, Canis familiaris"
xref: Reactome:REACT_77924 "Tetrahydrofolate polyglutamate (THF polyglutamate) + serine <=> 5,10-methyleneTHF polyglutamate + glycine, Danio rerio"
xref: Reactome:REACT_78152 "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine, Rattus norvegicus"
xref: Reactome:REACT_80167 "Tetrahydrofolate polyglutamate (THF polyglutamate) + serine <=> 5,10-methyleneTHF polyglutamate + glycine, Saccharomyces cerevisiae"
xref: Reactome:REACT_80412 "beta-hydroxy-trimethyllysine => gamma-butyrobetaine aldehyde + glycine, Oryza sativa"
xref: Reactome:REACT_81468 "Tetrahydrofolate polyglutamate (THF polyglutamate) + serine <=> 5,10-methyleneTHF polyglutamate + glycine, Bos taurus"
xref: Reactome:REACT_82542 "Tetrahydrofolate polyglutamate (THF polyglutamate) + serine <=> 5,10-methyleneTHF polyglutamate + glycine, Canis familiaris"
xref: Reactome:REACT_84260 "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine, Arabidopsis thaliana"
xref: Reactome:REACT_86594 "beta-hydroxy-trimethyllysine => gamma-butyrobetaine aldehyde + glycine, Bos taurus"
xref: Reactome:REACT_88214 "beta-hydroxy-trimethyllysine => gamma-butyrobetaine aldehyde + glycine, Drosophila melanogaster"
xref: Reactome:REACT_88519 "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine, Mus musculus"
xref: Reactome:REACT_89705 "beta-hydroxy-trimethyllysine => gamma-butyrobetaine aldehyde + glycine, Gallus gallus"
xref: Reactome:REACT_90130 "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine, Bos taurus"
xref: Reactome:REACT_90410 "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine, Drosophila melanogaster"
xref: Reactome:REACT_91337 "beta-hydroxy-trimethyllysine => gamma-butyrobetaine aldehyde + glycine, Xenopus tropicalis"
xref: Reactome:REACT_91776 "beta-hydroxy-trimethyllysine => gamma-butyrobetaine aldehyde + glycine, Caenorhabditis elegans"
xref: Reactome:REACT_92924 "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine, Caenorhabditis elegans"
xref: Reactome:REACT_93345 "beta-hydroxy-trimethyllysine => gamma-butyrobetaine aldehyde + glycine, Schizosaccharomyces pombe"
xref: Reactome:REACT_93885 "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine, Xenopus tropicalis"
xref: Reactome:REACT_95280 "beta-hydroxy-trimethyllysine => gamma-butyrobetaine aldehyde + glycine, Danio rerio"
xref: Reactome:REACT_95373 "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine, Schizosaccharomyces pombe"
xref: Reactome:REACT_95737 "beta-hydroxy-trimethyllysine => gamma-butyrobetaine aldehyde + glycine, Arabidopsis thaliana"
xref: Reactome:REACT_97896 "Tetrahydrofolate polyglutamate (THF polyglutamate) + serine <=> 5,10-methyleneTHF polyglutamate + glycine, Schizosaccharomyces pombe"
xref: Reactome:REACT_99194 "Tetrahydrofolate polyglutamate (THF polyglutamate) + serine <=> 5,10-methyleneTHF polyglutamate + glycine, Caenorhabditis elegans"
xref: RHEA:15484
is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity

[Term]
id: GO:0004373
name: glycogen (starch) synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UDP + (1,4)-alpha-D-glucosyl(n+1)." [EC:2.4.1.11]
subset: gosubset_prok
synonym: "glycogen (starch) synthetase activity" EXACT [EC:2.4.1.11]
synonym: "UDP-glucose-glycogen glucosyltransferase activity" EXACT [EC:2.4.1.11]
synonym: "UDP-glucose:glycogen 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.11]
synonym: "UDP-glycogen synthase activity" EXACT [EC:2.4.1.11]
synonym: "UDPG-glycogen synthetase activity" EXACT [EC:2.4.1.11]
synonym: "UDPG-glycogen transglucosylase activity" EXACT [EC:2.4.1.11]
synonym: "UDPglucose:glycogen 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.11]
synonym: "uridine diphosphoglucose-glycogen glucosyltransferase activity" EXACT [EC:2.4.1.11]
xref: EC:2.4.1.11
xref: MetaCyc:2.4.1.11-RXN
xref: Reactome:REACT_101890 "8 UDP-glucose + ((1,4)-alpha-D-glucosyl)4 glycogenin => 8 UDP + ((1,4)-alpha-D-glucosyl)8 glycogenin [GYS D form], Bos taurus"
xref: Reactome:REACT_1053 "8 UDP-glucose + ((1,4)-alpha-D-glucosyl)4 glycogenin => 8 UDP + ((1,4)-alpha-D-glucosyl)8 glycogenin [GYS D form], Homo sapiens"
xref: Reactome:REACT_108629 "8 UDP-glucose + ((1,4)-alpha-D-glucosyl)4 glycogenin => 8 UDP + ((1,4)-alpha-D-glucosyl)8 glycogenin [GYS D form], Saccharomyces cerevisiae"
xref: Reactome:REACT_110198 "8 UDP-glucose + ((1,4)-alpha-D-glucosyl}4 glycogenin => 8 UDP + ((1,4)-alpha-D-glucosyl)8 glycogenin [GYS I form], Xenopus tropicalis"
xref: Reactome:REACT_1169 "8 UDP-glucose + ((1,4)-alpha-D-glucosyl}4 glycogenin => 8 UDP + ((1,4)-alpha-D-glucosyl)8 glycogenin [GYS I form], Homo sapiens"
xref: Reactome:REACT_29331 "8 UDP-glucose + ((1,4)-alpha-D-glucosyl}4 glycogenin => 8 UDP + ((1,4)-alpha-D-glucosyl)8 glycogenin [GYS I form], Sus scrofa"
xref: Reactome:REACT_29979 "8 UDP-glucose + ((1,4)-alpha-D-glucosyl)4 glycogenin => 8 UDP + ((1,4)-alpha-D-glucosyl)8 glycogenin [GYS D form], Canis familiaris"
xref: Reactome:REACT_32243 "8 UDP-glucose + ((1,4)-alpha-D-glucosyl}4 glycogenin => 8 UDP + ((1,4)-alpha-D-glucosyl)8 glycogenin [GYS I form], Gallus gallus"
xref: Reactome:REACT_33183 "8 UDP-glucose + ((1,4)-alpha-D-glucosyl}4 glycogenin => 8 UDP + ((1,4)-alpha-D-glucosyl)8 glycogenin [GYS I form], Caenorhabditis elegans"
xref: Reactome:REACT_34684 "8 UDP-glucose + ((1,4)-alpha-D-glucosyl)4 glycogenin => 8 UDP + ((1,4)-alpha-D-glucosyl)8 glycogenin [GYS D form], Xenopus tropicalis"
xref: Reactome:REACT_77029 "8 UDP-glucose + ((1,4)-alpha-D-glucosyl)4 glycogenin => 8 UDP + ((1,4)-alpha-D-glucosyl)8 glycogenin [GYS D form], Caenorhabditis elegans"
xref: Reactome:REACT_78218 "8 UDP-glucose + ((1,4)-alpha-D-glucosyl)4 glycogenin => 8 UDP + ((1,4)-alpha-D-glucosyl)8 glycogenin [GYS D form], Taeniopygia guttata"
xref: Reactome:REACT_80007 "8 UDP-glucose + ((1,4)-alpha-D-glucosyl}4 glycogenin => 8 UDP + ((1,4)-alpha-D-glucosyl)8 glycogenin [GYS I form], Taeniopygia guttata"
xref: Reactome:REACT_80691 "8 UDP-glucose + ((1,4)-alpha-D-glucosyl}4 glycogenin => 8 UDP + ((1,4)-alpha-D-glucosyl)8 glycogenin [GYS I form], Mus musculus"
xref: Reactome:REACT_83229 "8 UDP-glucose + ((1,4)-alpha-D-glucosyl}4 glycogenin => 8 UDP + ((1,4)-alpha-D-glucosyl)8 glycogenin [GYS I form], Bos taurus"
xref: Reactome:REACT_87238 "8 UDP-glucose + ((1,4)-alpha-D-glucosyl}4 glycogenin => 8 UDP + ((1,4)-alpha-D-glucosyl)8 glycogenin [GYS I form], Saccharomyces cerevisiae"
xref: Reactome:REACT_89103 "8 UDP-glucose + ((1,4)-alpha-D-glucosyl}4 glycogenin => 8 UDP + ((1,4)-alpha-D-glucosyl)8 glycogenin [GYS I form], Rattus norvegicus"
xref: Reactome:REACT_89171 "8 UDP-glucose + ((1,4)-alpha-D-glucosyl)4 glycogenin => 8 UDP + ((1,4)-alpha-D-glucosyl)8 glycogenin [GYS D form], Rattus norvegicus"
xref: Reactome:REACT_91264 "8 UDP-glucose + ((1,4)-alpha-D-glucosyl)4 glycogenin => 8 UDP + ((1,4)-alpha-D-glucosyl)8 glycogenin [GYS D form], Danio rerio"
xref: Reactome:REACT_91828 "8 UDP-glucose + ((1,4)-alpha-D-glucosyl)4 glycogenin => 8 UDP + ((1,4)-alpha-D-glucosyl)8 glycogenin [GYS D form], Gallus gallus"
xref: Reactome:REACT_92346 "8 UDP-glucose + ((1,4)-alpha-D-glucosyl}4 glycogenin => 8 UDP + ((1,4)-alpha-D-glucosyl)8 glycogenin [GYS I form], Canis familiaris"
xref: Reactome:REACT_93795 "8 UDP-glucose + ((1,4)-alpha-D-glucosyl}4 glycogenin => 8 UDP + ((1,4)-alpha-D-glucosyl)8 glycogenin [GYS I form], Danio rerio"
xref: Reactome:REACT_95212 "8 UDP-glucose + ((1,4)-alpha-D-glucosyl)4 glycogenin => 8 UDP + ((1,4)-alpha-D-glucosyl)8 glycogenin [GYS D form], Mus musculus"
xref: Reactome:REACT_95765 "8 UDP-glucose + ((1,4)-alpha-D-glucosyl)4 glycogenin => 8 UDP + ((1,4)-alpha-D-glucosyl)8 glycogenin [GYS D form], Sus scrofa"
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0004374
name: obsolete glycine cleavage system
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reactions: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + carbon dioxide (CO2), followed by S-aminomethyldihydrolipoylprotein + (6S)-tetrahydrofolate = dihydrolipoylprotein + (6R)-5,10-methylenetetrahydrofolate + ammonia. Made up of two components, aminomethyltransferase and glycine dehydrogenase (decarboxylating)." [EC:1.4.4.2, EC:2.1.2.10]
comment: This term was made obsolete because it represents a process rather than a function.
synonym: "glycine cleavage system" EXACT []
synonym: "glycine synthase" BROAD []
is_obsolete: true
replaced_by: GO:0019464

[Term]
id: GO:0004375
name: glycine dehydrogenase (decarboxylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO2." [EC:1.4.4.2]
subset: gosubset_prok
synonym: "glycine cleavage system P-protein activity" NARROW [EC:1.4.4.2]
synonym: "glycine decarboxylase activity" EXACT [EC:1.4.4.2]
synonym: "glycine-cleavage complex" RELATED [EC:1.4.4.2]
synonym: "glycine-cleavage complex P-protein activity" EXACT [EC:1.4.4.2]
synonym: "glycine:H-protein-lipoyllysine oxidoreductase (decarboxylating, acceptor-amino-methylating)" EXACT [EC:1.4.4.2]
synonym: "glycine:lipoylprotein oxidoreductase (decarboxylating and acceptor-aminomethylating)" EXACT [EC:1.4.4.2]
synonym: "P-protein" NARROW [EC:1.4.4.2]
synonym: "protein P1" NARROW [EC:1.4.4.2]
xref: EC:1.4.4.2
xref: MetaCyc:GCVP-RXN
is_a: GO:0016642 ! oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor

[Term]
id: GO:0004376
name: glycolipid mannosyltransferase activity
namespace: molecular_function
alt_id: GO:0004580
def: "Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-D-mannosyl-D-mannose linkage." [GOC:ai]
synonym: "glycolipid mannosyl transferase activity" EXACT []
xref: EC:2.4.1.-
xref: Reactome:REACT_101404 "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_103363 "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate, Drosophila melanogaster"
xref: Reactome:REACT_103767 "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate, Plasmodium falciparum"
xref: Reactome:REACT_104167 "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate, Gallus gallus"
xref: Reactome:REACT_105006 "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate, Caenorhabditis elegans"
xref: Reactome:REACT_107148 "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate, Bos taurus"
xref: Reactome:REACT_108534 "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate, Gallus gallus"
xref: Reactome:REACT_109154 "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate, Arabidopsis thaliana"
xref: Reactome:REACT_111941 "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate, Xenopus tropicalis"
xref: Reactome:REACT_1308 "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate, Homo sapiens"
xref: Reactome:REACT_1848 "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate, Homo sapiens"
xref: Reactome:REACT_31390 "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate, Rattus norvegicus"
xref: Reactome:REACT_32639 "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate, Danio rerio"
xref: Reactome:REACT_33046 "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate, Plasmodium falciparum"
xref: Reactome:REACT_33165 "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate, Drosophila melanogaster"
xref: Reactome:REACT_78709 "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate, Sus scrofa"
xref: Reactome:REACT_78994 "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate, Sus scrofa"
xref: Reactome:REACT_79695 "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate, Dictyostelium discoideum"
xref: Reactome:REACT_79740 "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate, Mus musculus"
xref: Reactome:REACT_81302 "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate, Danio rerio"
xref: Reactome:REACT_84714 "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate, Oryza sativa"
xref: Reactome:REACT_85880 "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate, Oryza sativa"
xref: Reactome:REACT_86157 "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_87246 "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate, Rattus norvegicus"
xref: Reactome:REACT_88387 "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_89761 "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_90584 "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate, Taeniopygia guttata"
xref: Reactome:REACT_92255 "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate, Dictyostelium discoideum"
xref: Reactome:REACT_93107 "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate, Taeniopygia guttata"
xref: Reactome:REACT_94013 "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate, Mus musculus"
xref: Reactome:REACT_96422 "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate, Arabidopsis thaliana"
xref: Reactome:REACT_97884 "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate, Xenopus tropicalis"
xref: Reactome:REACT_98938 "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate, Bos taurus"
xref: Reactome:REACT_99322 "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate, Caenorhabditis elegans"
xref: Reactome:REACT_99674 "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate, Canis familiaris"
is_a: GO:0000030 ! mannosyltransferase activity

[Term]
id: GO:0004377
name: GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: an alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage." [EC:2.4.1.131]
synonym: "GDP-D-mannose:D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-1,2-mannosyltransferase activity" EXACT [EC:2.4.1.131]
synonym: "GDP-mannose-oligosaccharide-lipid mannosyltransferase activity" EXACT [EC:2.4.1.131]
synonym: "GDP-mannose:glycolipid 1,2-alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.131]
synonym: "glycolipid 2-alpha-mannosyltransferase activity" EXACT [EC:2.4.1.131]
synonym: "guanosine diphosphomannose-oligosaccharide-lipid mannosyltransferase activity" EXACT [EC:2.4.1.131]
synonym: "oligosaccharide-lipid mannosyltransferase activity" EXACT [EC:2.4.1.131]
xref: EC:2.4.1.131
xref: MetaCyc:2.4.1.131-RXN
xref: RHEA:29526
is_a: GO:0000026 ! alpha-1,2-mannosyltransferase activity
is_a: GO:0004376 ! glycolipid mannosyltransferase activity

[Term]
id: GO:0004378
name: GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose = alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + GDP + H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->3)-D-mannosyl-D-mannose linkage." [EC:2.4.1.132]
synonym: "GDP-D-mannose:D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol 3-alpha-mannosyltransferase activity" EXACT systematic_synonym [EC:2.4.1.132]
synonym: "GDP-mannose-oligosaccharide-lipid mannosyltransferase II" RELATED [EC:2.4.1.132]
synonym: "GDP-mannose:glycolipid 1,3-alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.132]
synonym: "glycolipid 3-alpha-mannosyltransferase activity" EXACT [EC:2.4.1.132]
synonym: "guanosine diphosphomannose-oligosaccharide-lipid II mannosyltransferase activity" EXACT [EC:2.4.1.132]
synonym: "mannosyltransferase II activity" EXACT [EC:2.4.1.132]
xref: EC:2.4.1.132
xref: MetaCyc:2.4.1.132-RXN
xref: RHEA:29518
is_a: GO:0004376 ! glycolipid mannosyltransferase activity

[Term]
id: GO:0004379
name: glycylpeptide N-tetradecanoyltransferase activity
namespace: molecular_function
alt_id: GO:0019106
def: "Catalysis of the reaction: tetradecanoyl-CoA + glycyl-peptide = CoA + N-tetradecanoylglycyl-peptide." [EC:2.3.1.97]
synonym: "myristoyl-CoA-protein N-myristoyltransferase activity" EXACT [EC:2.3.1.97]
synonym: "myristoyl-coenzyme A:protein N-myristoyl transferase activity" EXACT [EC:2.3.1.97]
synonym: "myristoylating enzymes" RELATED [EC:2.3.1.97]
synonym: "N-myristoyltransferase activity" EXACT []
synonym: "peptide N-myristoyltransferase activity" EXACT [EC:2.3.1.97]
synonym: "peptide N-tetradecanoyltransferase activity" EXACT [EC:2.3.1.97]
synonym: "protein N-myristoyltransferase activity" EXACT [EC:2.3.1.97]
synonym: "tetradecanoyl-CoA:glycylpeptide N-tetradecanoyltransferase activity" EXACT [EC:2.3.1.97]
xref: EC:2.3.1.97
xref: MetaCyc:2.3.1.97-RXN
xref: Reactome:REACT_115774 "N-myristoylation of GAG polyprotein by NMT2, Homo sapiens"
is_a: GO:0016410 ! N-acyltransferase activity
is_a: GO:0019107 ! myristoyltransferase activity

[Term]
id: GO:0004380
name: glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose." [EC:2.4.1.40]
synonym: "A transferase activity" RELATED [EC:2.4.1.40]
synonym: "A-transferase activity" EXACT [EC:2.4.1.40]
synonym: "alpha-3-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.40]
synonym: "blood-group substance A-dependent acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.40]
synonym: "blood-group substance alpha-acetyltransferase activity" EXACT [EC:2.4.1.40]
synonym: "fucosylgalactose acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.40]
synonym: "fucosylgalactose alpha-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.40]
synonym: "fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.40]
synonym: "histo-blood group A acetylgalactosaminyltransferase activity" NARROW [EC:2.4.1.40]
synonym: "histo-blood group A glycosyltransferase (Fucalpha1->2Galalpha1->3-N-acetylgalactosaminyltransferase)" EXACT [EC:2.4.1.40]
synonym: "histo-blood group A transferase activity" RELATED [EC:2.4.1.40]
synonym: "UDP-GalNAc:Fucalpha1->2Galalpha1->3-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.40]
synonym: "UDP-N-acetyl-D-galactosamine:alpha-L-fucosyl-1,2-D-galactose 3-N-acetyl-D-galactosaminyltransferase activity" EXACT [EC:2.4.1.40]
synonym: "UDP-N-acetyl-D-galactosamine:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-N-acetyl-D-galactosaminyltransferase activity" EXACT [EC:2.4.1.40]
xref: EC:2.4.1.40
xref: MetaCyc:2.4.1.40-RXN
is_a: GO:0008376 ! acetylgalactosaminyltransferase activity

[Term]
id: GO:0004381
name: fucosylgalactoside 3-alpha-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-galactose + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-alpha-D-galactosyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose." [EC:2.4.1.37]
synonym: "[blood group substance] alpha-galactosyltransferase activity" NARROW [EC:2.4.1.37]
synonym: "B transferase activity" RELATED [EC:2.4.1.37]
synonym: "blood-group substance B-dependent galactosyltransferase activity" NARROW [EC:2.4.1.37]
synonym: "blood-group substance beta-dependent galactosyltransferase activity" NARROW [EC:2.4.1.37]
synonym: "fucosylglycoprotein 3-alpha-galactosyltransferase activity" EXACT [EC:2.4.1.37]
synonym: "glycoprotein-fucosylgalactoside alpha-galactosyltransferase activity" EXACT []
synonym: "histo-blood group B transferase activity" NARROW [EC:2.4.1.37]
synonym: "histo-blood substance B-dependent galactosyltransferase activity" EXACT [EC:2.4.1.37]
synonym: "histo-blood substance beta-dependent galactosyltransferase activity" NARROW [EC:2.4.1.37]
synonym: "UDP-galactose:alpha-L-fucosyl-(1,2)-D-galactoside 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.37]
synonym: "UDP-galactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.37]
synonym: "UDPgalactose:alpha-L-fucosyl-(1,2)-D-galactoside 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.37]
synonym: "UDPgalactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.37]
synonym: "UDPgalactose:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.37]
synonym: "UDPgalactose:O-alpha-L-fucosyl(1,2)D-galactose alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.37]
synonym: "UDPgalactose:O-alpha-L-fucosyl(1->2)D-galactose alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.37]
xref: EC:2.4.1.37
xref: MetaCyc:2.4.1.37-RXN
xref: RHEA:14352
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0004382
name: guanosine-diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP + H2O = GMP + phosphate." [EC:3.6.1.42, PMID:2989286]
synonym: "GDP phosphohydrolase activity" EXACT [EC:3.6.1.42]
synonym: "GDPase activity" EXACT [EC:3.6.1.42]
synonym: "guanosine 5'-diphosphatase activity" EXACT [EC:3.6.1.6]
synonym: "guanosine diphosphatase activity" EXACT []
xref: EC:3.6.1.42
xref: MetaCyc:GUANOSINE-DIPHOSPHATASE-RXN
xref: RHEA:22159
is_a: GO:0017110 ! nucleoside-diphosphatase activity

[Term]
id: GO:0004383
name: guanylate cyclase activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2]
subset: gosubset_prok
synonym: "GTP diphosphate-lyase (cyclizing) activity" EXACT [EC:4.6.1.2]
synonym: "GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming) activity" EXACT [EC:4.6.1.2]
synonym: "guanyl cyclase activity" EXACT [EC:4.6.1.2]
synonym: "guanylyl cyclase activity" EXACT []
synonym: "receptor guanylate cyclase activity" NARROW []
xref: EC:4.6.1.2
xref: MetaCyc:GUANYLCYC-RXN
xref: Reactome:REACT_108080 "Soluble guanylate cyclase converts GTP to cGMP, Sus scrofa"
xref: Reactome:REACT_115231 "Soluble guanylate cyclase converts GTP to cGMP, Dictyostelium discoideum"
xref: Reactome:REACT_115362 "Soluble guanylate cyclase converts GTP to cGMP, Mycobacterium tuberculosis"
xref: Reactome:REACT_23790 "Soluble guanylate cyclase converts GTP to cGMP, Homo sapiens"
xref: Reactome:REACT_23978 "Soluble guanylate cyclase converts GTP to cGMP, Rattus norvegicus"
xref: Reactome:REACT_29218 "Soluble guanylate cyclase converts GTP to cGMP, Bos taurus"
xref: Reactome:REACT_30126 "Soluble guanylate cyclase converts GTP to cGMP, Drosophila melanogaster"
xref: Reactome:REACT_31354 "Soluble guanylate cyclase converts GTP to cGMP, Mus musculus"
xref: Reactome:REACT_32985 "Soluble guanylate cyclase converts GTP to cGMP, Xenopus tropicalis"
xref: Reactome:REACT_83069 "Soluble guanylate cyclase converts GTP to cGMP, Danio rerio"
xref: Reactome:REACT_85642 "Soluble guanylate cyclase converts GTP to cGMP, Taeniopygia guttata"
xref: Reactome:REACT_90434 "Soluble guanylate cyclase converts GTP to cGMP, Gallus gallus"
xref: Reactome:REACT_96120 "Soluble guanylate cyclase converts GTP to cGMP, Canis familiaris"
xref: RHEA:13668
is_a: GO:0009975 ! cyclase activity
is_a: GO:0016849 ! phosphorus-oxygen lyase activity
relationship: part_of GO:0006182 ! cGMP biosynthetic process

[Term]
id: GO:0004384
name: obsolete membrane-associated guanylate kinase
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + GMP = ADP + GDP, associated with the cell membrane." [EC:2.7.4.8]
comment: This term was made obsolete because it represents a gene product and not a function.
synonym: "MAGUK" EXACT []
synonym: "membrane-associated guanylate kinase" EXACT []
is_obsolete: true
consider: GO:0004385
consider: GO:0005102
consider: GO:0007155
consider: GO:0016021
consider: GO:0050839

[Term]
id: GO:0004385
name: guanylate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + GMP = ADP + GDP." [EC:2.7.4.8]
subset: gosubset_prok
synonym: "5'-GMP kinase activity" EXACT [EC:2.7.4.8]
synonym: "ATP:(d)GMP phosphotransferase activity" EXACT [EC:2.7.4.8]
synonym: "ATP:GMP phosphotransferase activity" EXACT [EC:2.7.4.8]
synonym: "deoxyguanylate kinase activity" RELATED [EC:2.7.4.8]
synonym: "GMP kinase activity" EXACT [EC:2.7.4.8]
synonym: "guanosine monophosphate kinase activity" EXACT [EC:2.7.4.8]
synonym: "membrane-associated guanylate kinase" NARROW []
xref: EC:2.7.4.8
xref: MetaCyc:GUANYL-KIN-RXN
xref: Reactome:REACT_104133 "(d)GMP + ATP <=> (d)GDP + ADP [GUK1], Taeniopygia guttata"
xref: Reactome:REACT_106028 "(d)GMP + ATP <=> (d)GDP + ADP [GUK1], Sus scrofa"
xref: Reactome:REACT_106389 "(d)GDP + ADP <=> (d)GMP + ATP [GUK1], Bos taurus"
xref: Reactome:REACT_108666 "(d)GMP + ATP <=> (d)GDP + ADP [GUK1], Mus musculus"
xref: Reactome:REACT_109318 "(d)GDP + ADP <=> (d)GMP + ATP [GUK1], Danio rerio"
xref: Reactome:REACT_110939 "(d)GDP + ADP <=> (d)GMP + ATP [GUK1], Xenopus tropicalis"
xref: Reactome:REACT_112127 "(d)GMP + ATP <=> (d)GDP + ADP [GUK1], Oryza sativa"
xref: Reactome:REACT_114888 "(d)GDP + ADP <=> (d)GMP + ATP [GUK1], Oryza sativa"
xref: Reactome:REACT_115196 "(d)GDP + ADP <=> (d)GMP + ATP [GUK1], Arabidopsis thaliana"
xref: Reactome:REACT_115456 "(d)GMP + ATP <=> (d)GDP + ADP [GUK1], Arabidopsis thaliana"
xref: Reactome:REACT_1256 "(d)GDP + ADP <=> (d)GMP + ATP [GUK1], Homo sapiens"
xref: Reactome:REACT_1606 "(d)GMP + ATP <=> (d)GDP + ADP [GUK1], Homo sapiens"
xref: Reactome:REACT_28761 "(d)GMP + ATP <=> (d)GDP + ADP [GUK1], Drosophila melanogaster"
xref: Reactome:REACT_31188 "(d)GMP + ATP <=> (d)GDP + ADP [GUK1], Bos taurus"
xref: Reactome:REACT_31346 "(d)GMP + ATP <=> (d)GDP + ADP [GUK1], Caenorhabditis elegans"
xref: Reactome:REACT_31866 "(d)GMP + ATP <=> (d)GDP + ADP [GUK1], Danio rerio"
xref: Reactome:REACT_33129 "(d)GDP + ADP <=> (d)GMP + ATP [GUK1], Rattus norvegicus"
xref: Reactome:REACT_33400 "(d)GMP + ATP <=> (d)GDP + ADP [GUK1], Rattus norvegicus"
xref: Reactome:REACT_33774 "(d)GDP + ADP <=> (d)GMP + ATP [GUK1], Gallus gallus"
xref: Reactome:REACT_81686 "(d)GDP + ADP <=> (d)GMP + ATP [GUK1], Mus musculus"
xref: Reactome:REACT_84577 "(d)GDP + ADP <=> (d)GMP + ATP [GUK1], Canis familiaris"
xref: Reactome:REACT_85414 "(d)GDP + ADP <=> (d)GMP + ATP [GUK1], Caenorhabditis elegans"
xref: Reactome:REACT_86007 "(d)GDP + ADP <=> (d)GMP + ATP [GUK1], Drosophila melanogaster"
xref: Reactome:REACT_86484 "(d)GDP + ADP <=> (d)GMP + ATP [GUK1], Sus scrofa"
xref: Reactome:REACT_89391 "(d)GDP + ADP <=> (d)GMP + ATP [GUK1], Taeniopygia guttata"
xref: Reactome:REACT_90955 "(d)GMP + ATP <=> (d)GDP + ADP [GUK1], Gallus gallus"
xref: Reactome:REACT_91717 "(d)GMP + ATP <=> (d)GDP + ADP [GUK1], Canis familiaris"
xref: Reactome:REACT_99219 "(d)GMP + ATP <=> (d)GDP + ADP [GUK1], Xenopus tropicalis"
xref: RHEA:20783
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor
is_a: GO:0019201 ! nucleotide kinase activity
relationship: part_of GO:0046037 ! GMP metabolic process
relationship: part_of GO:0046710 ! GDP metabolic process

[Term]
id: GO:0004386
name: helicase activity
namespace: molecular_function
def: "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
comment: Note that most helicases catalyze processive duplex unwinding.
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
xref: Reactome:REACT_101111 "Addition of the third nucleotide on the nascent transcript, Saccharomyces cerevisiae"
xref: Reactome:REACT_101247 "Formation of open bubble structure in DNA by helicases, Bos taurus"
xref: Reactome:REACT_101622 "MCM8 mediated fork unwinding, Danio rerio"
xref: Reactome:REACT_101644 "Formation of open bubble structure in DNA by helicases, Oryza sativa"
xref: Reactome:REACT_101823 "MCM2-7 mediated fork unwinding, Plasmodium falciparum"
xref: Reactome:REACT_101994 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Xenopus tropicalis"
xref: Reactome:REACT_102121 "Addition of the third nucleotide on the nascent transcript, Rattus norvegicus"
xref: Reactome:REACT_102441 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Gallus gallus"
xref: Reactome:REACT_102560 "MCM2-7 mediated fork unwinding, Oryza sativa"
xref: Reactome:REACT_1033 "Formation of open bubble structure in DNA by helicases, Homo sapiens"
xref: Reactome:REACT_103861 "MCM8 mediated fork unwinding, Bos taurus"
xref: Reactome:REACT_103881 "RNA Polymerase II Promoter Opening: First Transition, Dictyostelium discoideum"
xref: Reactome:REACT_103897 "MCM8 mediated fork unwinding, Mus musculus"
xref: Reactome:REACT_103959 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Rattus norvegicus"
xref: Reactome:REACT_104221 "MCM2-7 mediated fork unwinding, Rattus norvegicus"
xref: Reactome:REACT_105950 "MCM2-7 mediated fork unwinding, Xenopus tropicalis"
xref: Reactome:REACT_106346 "Formation of open bubble structure in DNA by helicases, Taeniopygia guttata"
xref: Reactome:REACT_107072 "Formation of open bubble structure in DNA by helicases, Mus musculus"
xref: Reactome:REACT_107495 "RNA Polymerase II Promoter Opening: First Transition, Taeniopygia guttata"
xref: Reactome:REACT_108159 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Dictyostelium discoideum"
xref: Reactome:REACT_108648 "Addition of the third nucleotide on the nascent transcript, Arabidopsis thaliana"
xref: Reactome:REACT_108654 "MCM2-7 mediated fork unwinding, Schizosaccharomyces pombe"
xref: Reactome:REACT_109035 "RNA Polymerase II Promoter Opening: First Transition, Schizosaccharomyces pombe"
xref: Reactome:REACT_109161 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Arabidopsis thaliana"
xref: Reactome:REACT_110588 "MCM8 mediated fork unwinding, Xenopus tropicalis"
xref: Reactome:REACT_110827 "Formation of open bubble structure in DNA by helicases, Danio rerio"
xref: Reactome:REACT_110845 "Cap-bound mRNA is activated by helicases, Mus musculus"
xref: Reactome:REACT_112208 "MCM8 mediated fork unwinding, Drosophila melanogaster"
xref: Reactome:REACT_112817 "Cap-bound mRNA is activated by helicases, Schizosaccharomyces pombe"
xref: Reactome:REACT_113177 "Formation of open bubble structure in DNA by helicases, Caenorhabditis elegans"
xref: Reactome:REACT_1521 "Cap-bound mRNA is activated by helicases, Homo sapiens"
xref: Reactome:REACT_1817 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Homo sapiens"
xref: Reactome:REACT_1844 "RNA Polymerase II Promoter Opening: First Transition, Homo sapiens"
xref: Reactome:REACT_28131 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Drosophila melanogaster"
xref: Reactome:REACT_28343 "MCM2-7 mediated fork unwinding, Danio rerio"
xref: Reactome:REACT_28810 "Addition of the third nucleotide on the nascent transcript, Oryza sativa"
xref: Reactome:REACT_28880 "MCM2-7 mediated fork unwinding, Drosophila melanogaster"
xref: Reactome:REACT_29155 "Addition of the third nucleotide on the nascent transcript, Drosophila melanogaster"
xref: Reactome:REACT_29217 "Formation of open bubble structure in DNA by helicases, Xenopus tropicalis"
xref: Reactome:REACT_29818 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Oryza sativa"
xref: Reactome:REACT_29850 "RNA Polymerase II Promoter Opening: First Transition, Saccharomyces cerevisiae"
xref: Reactome:REACT_30013 "MCM8 mediated fork unwinding, Rattus norvegicus"
xref: Reactome:REACT_30989 "MCM8 mediated fork unwinding, Arabidopsis thaliana"
xref: Reactome:REACT_31034 "Cap-bound mRNA is activated by helicases, Danio rerio"
xref: Reactome:REACT_31090 "MCM2-7 mediated fork unwinding, Gallus gallus"
xref: Reactome:REACT_31554 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Schizosaccharomyces pombe"
xref: Reactome:REACT_32533 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Caenorhabditis elegans"
xref: Reactome:REACT_33205 "MCM8 mediated fork unwinding, Canis familiaris"
xref: Reactome:REACT_34016 "Formation of open bubble structure in DNA by helicases, Rattus norvegicus"
xref: Reactome:REACT_34089 "MCM2-7 mediated fork unwinding, Dictyostelium discoideum"
xref: Reactome:REACT_34560 "MCM8 mediated fork unwinding, Sus scrofa"
xref: Reactome:REACT_40 "Addition of the third nucleotide on the nascent transcript, Homo sapiens"
xref: Reactome:REACT_6134 "HIV-1 Promoter Opening: First Transition, Homo sapiens"
xref: Reactome:REACT_6184 "Addition of the fourth nucleotide on the nascent HIV-1 transcript: Second Transition, Homo sapiens"
xref: Reactome:REACT_6325 "Addition of the third nucleotide on the nascent HIV-1 transcript, Homo sapiens"
xref: Reactome:REACT_6758 "Xenopus Mcm8 mediated fork unwinding, Xenopus laevis"
xref: Reactome:REACT_6768 "MCM8 mediated fork unwinding, Homo sapiens"
xref: Reactome:REACT_6853 "Yeast Mcm2-7 mediated fork unwinding, Saccharomyces cerevisiae"
xref: Reactome:REACT_6922 "MCM2-7 mediated fork unwinding, Homo sapiens"
xref: Reactome:REACT_78086 "RNA Polymerase II Promoter Opening: First Transition, Rattus norvegicus"
xref: Reactome:REACT_78462 "Formation of open bubble structure in DNA by helicases, Drosophila melanogaster"
xref: Reactome:REACT_78667 "MCM2-7 mediated fork unwinding, Canis familiaris"
xref: Reactome:REACT_78771 "MCM8 mediated fork unwinding, Dictyostelium discoideum"
xref: Reactome:REACT_79759 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Mus musculus"
xref: Reactome:REACT_80107 "RNA Polymerase II Promoter Opening: First Transition, Arabidopsis thaliana"
xref: Reactome:REACT_80325 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Danio rerio"
xref: Reactome:REACT_80500 "MCM8 mediated fork unwinding, Gallus gallus"
xref: Reactome:REACT_80532 "Addition of the third nucleotide on the nascent transcript, Gallus gallus"
xref: Reactome:REACT_80605 "Addition of the third nucleotide on the nascent transcript, Mus musculus"
xref: Reactome:REACT_81126 "Addition of the third nucleotide on the nascent transcript, Schizosaccharomyces pombe"
xref: Reactome:REACT_81335 "RNA Polymerase II Promoter Opening: First Transition, Gallus gallus"
xref: Reactome:REACT_81427 "MCM8 mediated fork unwinding, Taeniopygia guttata"
xref: Reactome:REACT_81441 "MCM8 mediated fork unwinding, Oryza sativa"
xref: Reactome:REACT_81682 "Formation of open bubble structure in DNA by helicases, Canis familiaris"
xref: Reactome:REACT_82776 "RNA Polymerase II Promoter Opening: First Transition, Danio rerio"
xref: Reactome:REACT_83794 "Formation of open bubble structure in DNA by helicases, Gallus gallus"
xref: Reactome:REACT_84565 "Formation of open bubble structure in DNA by helicases, Schizosaccharomyces pombe"
xref: Reactome:REACT_84574 "Cap-bound mRNA is activated by helicases, Canis familiaris"
xref: Reactome:REACT_84809 "MCM2-7 mediated fork unwinding, Mus musculus"
xref: Reactome:REACT_84907 "MCM2-7 mediated fork unwinding, Taeniopygia guttata"
xref: Reactome:REACT_85111 "Cap-bound mRNA is activated by helicases, Drosophila melanogaster"
xref: Reactome:REACT_85172 "MCM2-7 mediated fork unwinding, Arabidopsis thaliana"
xref: Reactome:REACT_86220 "MCM2-7 mediated fork unwinding, Caenorhabditis elegans"
xref: Reactome:REACT_88362 "Addition of the third nucleotide on the nascent transcript, Caenorhabditis elegans"
xref: Reactome:REACT_89000 "MCM2-7 mediated fork unwinding, Bos taurus"
xref: Reactome:REACT_89030 "Formation of open bubble structure in DNA by helicases, Saccharomyces cerevisiae"
xref: Reactome:REACT_89363 "Addition of the third nucleotide on the nascent transcript, Xenopus tropicalis"
xref: Reactome:REACT_89694 "RNA Polymerase II Promoter Opening: First Transition, Drosophila melanogaster"
xref: Reactome:REACT_91822 "MCM8 mediated fork unwinding, Plasmodium falciparum"
xref: Reactome:REACT_93391 "RNA Polymerase II Promoter Opening: First Transition, Oryza sativa"
xref: Reactome:REACT_93711 "RNA Polymerase II Promoter Opening: First Transition, Mus musculus"
xref: Reactome:REACT_94645 "RNA Polymerase II Promoter Opening: First Transition, Xenopus tropicalis"
xref: Reactome:REACT_94679 "RNA Polymerase II Promoter Opening: First Transition, Caenorhabditis elegans"
xref: Reactome:REACT_95942 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Saccharomyces cerevisiae"
xref: Reactome:REACT_95993 "Formation of open bubble structure in DNA by helicases, Arabidopsis thaliana"
xref: Reactome:REACT_98273 "Addition of the third nucleotide on the nascent transcript, Dictyostelium discoideum"
xref: Reactome:REACT_98302 "Formation of open bubble structure in DNA by helicases, Sus scrofa"
xref: Reactome:REACT_98745 "Cap-bound mRNA is activated by helicases, Xenopus tropicalis"
xref: Reactome:REACT_99120 "Addition of the third nucleotide on the nascent transcript, Danio rerio"
is_a: GO:0017111 ! nucleoside-triphosphatase activity

[Term]
id: GO:0004392
name: heme oxygenase (decyclizing) activity
namespace: molecular_function
def: "Catalysis of the reaction: heme + 3 donor-H2 + 3 O2 = biliverdin + Fe2+ + CO + 3 acceptor + 3 H2O." [EC:1.14.99.3]
synonym: "haem oxidase activity" EXACT [EC:1.14.99.3]
synonym: "haem oxygenase (decyclizing) activity" EXACT []
synonym: "haem oxygenase activity" EXACT [EC:1.14.99.3]
synonym: "heme oxidase activity" EXACT [EC:1.14.99.3]
synonym: "heme oxygenase activity" EXACT [EC:1.14.99.3]
synonym: "heme,hydrogen-donor:oxygen oxidoreductase (alpha-methene-oxidizing, hydroxylating)" EXACT [EC:1.14.99.3]
synonym: "ORP33 proteins" RELATED [EC:1.14.99.3]
xref: EC:1.14.99.3
xref: MetaCyc:HEME-OXYGENASE-DECYCLIZING-RXN
xref: Reactome:REACT_22100 "The heme ring is cleaved by heme oxygenase, Homo sapiens"
xref: Reactome:REACT_29672 "The heme ring is cleaved by heme oxygenase, Taeniopygia guttata"
xref: Reactome:REACT_32670 "The heme ring is cleaved by heme oxygenase, Mus musculus"
xref: Reactome:REACT_34442 "The heme ring is cleaved by heme oxygenase, Danio rerio"
xref: Reactome:REACT_44544 "The heme ring is cleaved by heme oxygenase, Canis familiaris"
xref: Reactome:REACT_80835 "The heme ring is cleaved by heme oxygenase, Rattus norvegicus"
xref: Reactome:REACT_86213 "The heme ring is cleaved by heme oxygenase, Bos taurus"
xref: Reactome:REACT_91230 "The heme ring is cleaved by heme oxygenase, Xenopus tropicalis"
xref: Reactome:REACT_91796 "The heme ring is cleaved by heme oxygenase, Drosophila melanogaster"
xref: Reactome:REACT_99289 "The heme ring is cleaved by heme oxygenase, Sus scrofa"
xref: Reactome:REACT_99482 "The heme ring is cleaved by heme oxygenase, Gallus gallus"
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0004394
name: heparan sulfate 2-O-sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 2-O-sulfate; results in 2-O-sulfation of iduronic acid residues in heparan sulfate." [PMID:9153262]
synonym: "heparan-sulfate 2-O-sulphotransferase activity" EXACT []
synonym: "heparin 2-sulfotransferase activity" RELATED []
synonym: "heparin-sulphate 2-sulphotransferase activity" RELATED []
xref: EC:2.8.2.-
is_a: GO:0034483 ! heparan sulfate sulfotransferase activity

[Term]
id: GO:0004395
name: hexaprenyldihydroxybenzoate methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3-hexaprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-hexaprenyl-4-hydroxy-5-methoxybenzoate." [EC:2.1.1.114]
synonym: "3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase activity" EXACT [EC:2.1.1.114]
synonym: "DHHB methyltransferase activity" EXACT [EC:2.1.1.114]
synonym: "DHHB-Mt activity" EXACT [EC:2.1.1.114]
synonym: "dihydroxyhexaprenylbenzoate methyltransferase activity" EXACT [EC:2.1.1.114]
synonym: "S-adenosyl-L-methionine:3-hexaprenyl-4,5-dihydroxylate O-methyltransferase activity" EXACT [EC:2.1.1.114]
xref: EC:2.1.1.114
xref: MetaCyc:2.1.1.114-RXN
xref: RHEA:14124
is_a: GO:0010420 ! polyprenyldihydroxybenzoate methyltransferase activity

[Term]
id: GO:0004396
name: hexokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate." [EC:2.7.1.1]
subset: gosubset_prok
synonym: "ATP-dependent hexokinase activity" EXACT [EC:2.7.1.1]
synonym: "ATP:D-hexose 6-phosphotransferase activity" EXACT [EC:2.7.1.1]
synonym: "glucose ATP phosphotransferase activity" EXACT [EC:2.7.1.1]
synonym: "hexokinase (phosphorylating)" EXACT [EC:2.7.1.1]
synonym: "hexokinase D" RELATED [EC:2.7.1.1]
synonym: "hexokinase type I activity" NARROW [EC:2.7.1.1]
synonym: "hexokinase type II activity" NARROW [EC:2.7.1.1]
synonym: "hexokinase type III activity" NARROW [EC:2.7.1.1]
synonym: "hexokinase type IV" RELATED [EC:2.7.1.1]
synonym: "hexokinase type IV (glucokinase) activity" NARROW [EC:2.7.1.1]
synonym: "hexokinase type IV glucokinase activity" EXACT [EC:2.7.1.1]
xref: EC:2.7.1.1
xref: MetaCyc:HEXOKINASE-RXN
xref: RHEA:22743
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0004397
name: histidine ammonia-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-histidine = urocanate + NH3." [EC:4.3.1.3]
subset: gosubset_prok
synonym: "histidase activity" RELATED [GOC:hjd]
synonym: "histidinase activity" RELATED [GOC:hjd]
synonym: "histidine alpha-deaminase activity" RELATED [GOC:hjd]
synonym: "L-histidine ammonia-lyase (urocanate-forming)" EXACT [EC:4.3.1.3]
synonym: "L-histidine ammonia-lyase activity" EXACT [EC:4.3.1.3]
xref: EC:4.3.1.3
xref: MetaCyc:HISTIDINE-AMMONIA-LYASE-RXN
xref: Reactome:REACT_107886 "histidine => urocanate + NH4+, Sus scrofa"
xref: Reactome:REACT_1225 "histidine => urocanate + NH4+, Homo sapiens"
xref: Reactome:REACT_31362 "histidine => urocanate + NH4+, Rattus norvegicus"
xref: Reactome:REACT_31818 "histidine => urocanate + NH4+, Mus musculus"
xref: Reactome:REACT_33743 "histidine => urocanate + NH4+, Gallus gallus"
xref: Reactome:REACT_77456 "histidine => urocanate + NH4+, Xenopus tropicalis"
xref: Reactome:REACT_78794 "histidine => urocanate + NH4+, Taeniopygia guttata"
xref: Reactome:REACT_81416 "histidine => urocanate + NH4+, Danio rerio"
xref: Reactome:REACT_82994 "histidine => urocanate + NH4+, Caenorhabditis elegans"
xref: Reactome:REACT_83342 "histidine => urocanate + NH4+, Bos taurus"
xref: Reactome:REACT_86125 "histidine => urocanate + NH4+, Dictyostelium discoideum"
xref: Reactome:REACT_94858 "histidine => urocanate + NH4+, Canis familiaris"
xref: Reactome:REACT_97533 "histidine => urocanate + NH4+, Staphylococcus aureus N315"
xref: RHEA:21235
is_a: GO:0016841 ! ammonia-lyase activity

[Term]
id: GO:0004398
name: histidine decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-histidine = histamine + CO2." [EC:4.1.1.22]
subset: gosubset_prok
synonym: "L-histidine carboxy-lyase (histamine-forming)" EXACT [EC:4.1.1.22]
synonym: "L-histidine carboxy-lyase activity" EXACT [EC:4.1.1.22]
synonym: "L-histidine decarboxylase activity" EXACT [EC:4.1.1.22]
xref: EC:4.1.1.22
xref: MetaCyc:HISTIDINE-DECARBOXYLASE-RXN
xref: Reactome:REACT_115661 "Histidine is decarboxylated to histamine, Homo sapiens"
xref: RHEA:20843
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004399
name: histidinol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-histidinol + NAD+ = L-histidine + NADH + H+." [EC:1.1.1.23]
subset: gosubset_prok
xref: EC:1.1.1.23
xref: MetaCyc:HISTALDEHYD-RXN
xref: MetaCyc:HISTOLDEHYD-RXN
xref: RHEA:20644
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004400
name: histidinol-phosphate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-histidinol-phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate." [EC:2.6.1.9]
subset: gosubset_prok
synonym: "glutamic-imidazoleacetol phosphate transaminase activity" EXACT [EC:2.6.1.9]
synonym: "histidine:imidazoleacetol phosphate transaminase activity" EXACT [EC:2.6.1.9]
synonym: "histidinol phosphate aminotransferase activity" EXACT [EC:2.6.1.9]
synonym: "histidinol-phosphate aminotransferase activity" EXACT []
synonym: "IAP transaminase activity" EXACT [EC:2.6.1.9]
synonym: "imidazole acetol-phosphate transaminase activity" EXACT [EC:2.6.1.9]
synonym: "imidazoleacetol phosphate transaminase activity" EXACT [EC:2.6.1.9]
synonym: "imidazolylacetolphosphate aminotransferase activity" EXACT [EC:2.6.1.9]
synonym: "imidazolylacetolphosphate transaminase activity" EXACT [EC:2.6.1.9]
synonym: "L-histidinol phosphate aminotransferase activity" EXACT [EC:2.6.1.9]
synonym: "L-histidinol-phosphate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.9]
xref: EC:2.6.1.9
xref: MetaCyc:HISTAMINOTRANS-RXN
xref: RHEA:23747
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0004401
name: histidinol-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-histidinol phosphate + H(2)O = L-histidinol + phosphate." [EC:3.1.3.15, RHEA:14468]
subset: gosubset_prok
synonym: "histidinol phosphate phosphatase activity" EXACT [EC:3.1.3.15]
synonym: "histidinolphosphatase activity" EXACT [EC:3.1.3.15]
synonym: "histidinolphosphate phosphatase activity" EXACT [EC:3.1.3.15]
synonym: "HPpase activity" EXACT [EC:3.1.3.15]
synonym: "L-histidinol phosphate phosphatase activity" EXACT [EC:3.1.3.15]
synonym: "L-histidinol-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.15]
xref: EC:3.1.3.15
xref: KEGG:R03013
xref: MetaCyc:HISTIDPHOS-RXN
xref: RHEA:14468
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0004402
name: histone acetyltransferase activity
namespace: molecular_function
alt_id: GO:0004403
alt_id: GO:0004404
alt_id: GO:0004405
alt_id: GO:0004406
alt_id: GO:0043166
alt_id: GO:0046971
def: "Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]
comment: Note that the term 'histone lysine acetyltransferase activity ; GO:0046971' was merged into this term because only lysine residues are ever acetylated in histones, and so the term was redundant.
synonym: "acetyl-CoA:histone acetyltransferase activity" EXACT [EC:2.3.1.48]
synonym: "H2A/H2B histone acetyltransferase activity" NARROW []
synonym: "H3/H4 histone acetyltransferase activity" NARROW []
synonym: "H4/H2 histone acetyltransferase activity" NARROW []
synonym: "H4/H2A acetyltransferase activity" NARROW []
synonym: "histone acetokinase activity" EXACT [EC:2.3.1.48]
synonym: "histone acetylase activity" EXACT []
synonym: "histone lysine acetyltransferase activity" EXACT []
synonym: "histone transacetylase activity" EXACT [EC:2.3.1.48]
synonym: "nucleosome-histone acetyltransferase activity" RELATED [EC:2.3.1.48]
xref: EC:2.3.1.48
xref: MetaCyc:HISTONE-ACETYLTRANSFERASE-RXN
is_a: GO:0061733 ! peptide-lysine-N-acetyltransferase activity
relationship: part_of GO:0016573 ! histone acetylation

[Term]
id: GO:0004407
name: histone deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes." [EC:3.5.1.98, PMID:9893272]
xref: EC:3.5.1.98
xref: MetaCyc:3.5.1.98-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0033558 ! protein deacetylase activity
relationship: part_of GO:0016575 ! histone deacetylation

[Term]
id: GO:0004408
name: holocytochrome-c synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: holocytochrome c = apocytochrome c + heme." [EC:4.4.1.17]
subset: gosubset_prok
synonym: "cytochrome c heme-lyase activity" EXACT [EC:4.4.1.17]
synonym: "cytochrome c synthase activity" RELATED [EC:4.4.1.17]
synonym: "holocytochrome c synthetase activity" EXACT [EC:4.4.1.17]
synonym: "holocytochrome-c apocytochrome-c-lyase (heme-forming)" EXACT [EC:4.4.1.17]
synonym: "holocytochrome-c apocytochrome-c-lyase activity" EXACT [EC:4.4.1.17]
xref: EC:4.4.1.17
xref: MetaCyc:HOLOCYTOCHROME-C-SYNTHASE-RXN
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0004409
name: homoaconitate hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (-)-homoisocitrate = cis-homoaconitate + H(2)O." [EC:4.2.1.36, RHEA:15488]
subset: gosubset_prok
synonym: "(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate hydro-lyase [(Z)-but-1-ene-1,2,4-tricarboxylate-forming]" RELATED [EC:4.2.1.36]
synonym: "2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase activity" EXACT [EC:4.2.1.36]
synonym: "cis-homoaconitase activity" EXACT [EC:4.2.1.36]
synonym: "HACN activity" EXACT [EC:4.2.1.36]
synonym: "homoaconitase activity" EXACT [EC:4.2.1.36]
synonym: "Lys4" RELATED [EC:4.2.1.36]
synonym: "LysF" RELATED [EC:4.2.1.36]
xref: EC:4.2.1.36
xref: KEGG:R04371
xref: MetaCyc:HOMOACONITATE-HYDRATASE-RXN
xref: RHEA:15488
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0004410
name: homocitrate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + acetyl-CoA + H(2)O = CoA + H(+) + homocitrate." [EC:2.3.3.14, RHEA:12932]
comment: Note that this function was formerly EC:4.1.3.21.
subset: gosubset_prok
synonym: "2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA- acetylating) activity" EXACT [EC:2.3.3.14]
synonym: "2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acetylating)" EXACT [EC:2.3.3.14]
synonym: "acetyl-CoA:2-oxoglutarate C-acetyltransferase (thioester-hydrolysing, carboxymethyl forming)" EXACT [EC:2.3.3.14]
synonym: "acetyl-coenzyme A:2-ketoglutarate C-acetyl transferase activity" EXACT [EC:2.3.3.14]
synonym: "homocitrate synthetase activity" EXACT [EC:2.3.3.14]
xref: EC:2.3.3.14
xref: KEGG:R00271
xref: MetaCyc:HOMOCITRATE-SYNTHASE-RXN
xref: RHEA:12932
is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

[Term]
id: GO:0004411
name: homogentisate 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: homogentisate + O(2) = 4-maleylacetoacetate + H(+)." [EC:1.13.11.5, RHEA:15452]
subset: gosubset_prok
synonym: "homogentisate dioxygenase activity" EXACT [EC:1.13.11.5]
synonym: "homogentisate oxidase activity" EXACT [EC:1.13.11.5]
synonym: "homogentisate oxygenase activity" EXACT [EC:1.13.11.5]
synonym: "homogentisate:oxygen 1,2-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.5]
synonym: "homogentisic acid oxidase activity" EXACT [EC:1.13.11.5]
synonym: "homogentisic acid oxygenase activity" EXACT [EC:1.13.11.5]
synonym: "homogentisic oxygenase activity" EXACT [EC:1.13.11.5]
synonym: "homogentisicase activity" EXACT [EC:1.13.11.5]
xref: EC:1.13.11.5
xref: KEGG:R02519
xref: MetaCyc:HOMOGENTISATE-12-DIOXYGENASE-RXN
xref: Reactome:REACT_103052 "homogentisate + O2 => maleylacetoacetate, Arabidopsis thaliana"
xref: Reactome:REACT_103099 "homogentisate + O2 => maleylacetoacetate, Taeniopygia guttata"
xref: Reactome:REACT_109538 "homogentisate + O2 => maleylacetoacetate, Dictyostelium discoideum"
xref: Reactome:REACT_110237 "homogentisate + O2 => maleylacetoacetate, Caenorhabditis elegans"
xref: Reactome:REACT_110856 "homogentisate + O2 => maleylacetoacetate, Bos taurus"
xref: Reactome:REACT_28670 "homogentisate + O2 => maleylacetoacetate, Danio rerio"
xref: Reactome:REACT_34678 "homogentisate + O2 => maleylacetoacetate, Drosophila melanogaster"
xref: Reactome:REACT_34681 "homogentisate + O2 => maleylacetoacetate, Canis familiaris"
xref: Reactome:REACT_557 "homogentisate + O2 => maleylacetoacetate, Homo sapiens"
xref: Reactome:REACT_77468 "homogentisate + O2 => maleylacetoacetate, Rattus norvegicus"
xref: Reactome:REACT_84706 "homogentisate + O2 => maleylacetoacetate, Oryza sativa"
xref: Reactome:REACT_90899 "homogentisate + O2 => maleylacetoacetate, Mus musculus"
xref: Reactome:REACT_93178 "homogentisate + O2 => maleylacetoacetate, Gallus gallus"
xref: Reactome:REACT_98158 "homogentisate + O2 => maleylacetoacetate, Xenopus tropicalis"
xref: RHEA:15452
xref: UM-BBD_reactionID:r0105
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0004412
name: homoserine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-homoserine + NADP+ = L-aspartate-4-semialdehyde + NADPH + H+." [EC:1.1.1.3]
subset: gosubset_prok
xref: EC:1.1.1.3
xref: MetaCyc:HOMOSERDEHYDROG-RXN
xref: RHEA:15764
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004413
name: homoserine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-homoserine + ATP = O-phospho-L-homoserine + ADP + 2 H(+)." [EC:2.7.1.39, RHEA:13988]
subset: gosubset_prok
synonym: "ATP:L-homoserine O-phosphotransferase activity" EXACT [EC:2.7.1.39]
synonym: "homoserine kinase (phosphorylating)" EXACT [EC:2.7.1.39]
synonym: "HSK" RELATED [EC:2.7.1.39]
xref: EC:2.7.1.39
xref: KEGG:R01771
xref: MetaCyc:HOMOSERKIN-RXN
xref: RHEA:13988
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019202 ! amino acid kinase activity

[Term]
id: GO:0004414
name: homoserine O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-homoserine + acetyl-CoA = O-acetyl-L-homoserine + CoA." [EC:2.3.1.31, RHEA:13704]
subset: gosubset_prok
synonym: "acetyl-CoA:L-homoserine O-acetyltransferase activity" EXACT [EC:2.3.1.31]
synonym: "homoserine acetyltransferase activity" EXACT [EC:2.3.1.31]
synonym: "homoserine O-trans-acetylase activity" EXACT [EC:2.3.1.31]
synonym: "homoserine transacetylase activity" BROAD [EC:2.3.1.31]
synonym: "homoserine-O-transacetylase activity" EXACT [EC:2.3.1.31]
synonym: "L-homoserine O-acetyltransferase activity" EXACT [EC:2.3.1.31]
xref: EC:2.3.1.31
xref: KEGG:R01776
xref: MetaCyc:HOMOSERINE-O-ACETYLTRANSFERASE-RXN
xref: RHEA:13704
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0004415
name: hyalurononglucosaminidase activity
namespace: molecular_function
def: "Catalysis of the random hydrolysis of (1->4) linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate." [EC:3.2.1.35]
subset: gosubset_prok
synonym: "chondroitinase activity" BROAD [EC:3.2.1.35]
synonym: "chondroitinase I activity" EXACT [EC:3.2.1.35]
synonym: "hyaluronate 4-glycanohydrolase activity" EXACT [EC:3.2.1.35]
synonym: "hyaluronidase activity" BROAD [EC:3.2.1.35]
synonym: "hyaluronoglucosaminidase activity" EXACT []
synonym: "hyaluronoglucosidase activity" EXACT [EC:3.2.1.35]
xref: EC:3.2.1.35
xref: MetaCyc:3.2.1.35-RXN
is_a: GO:0015929 ! hexosaminidase activity

[Term]
id: GO:0004416
name: hydroxyacylglutathione hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate." [EC:3.1.2.6]
subset: gosubset_prok
synonym: "acetoacetylglutathione hydrolase activity" EXACT [EC:3.1.2.6]
synonym: "glyoxalase II activity" EXACT [EC:3.1.2.6]
synonym: "S-(2-hydroxyacyl)glutathione hydrolase activity" EXACT [EC:3.1.2.6]
synonym: "S-2-hydroxylacylglutathione hydrolase activity" EXACT [EC:3.1.2.6]
xref: EC:3.1.2.6
xref: MetaCyc:GLYOXII-RXN
xref: RHEA:25248
is_a: GO:0016790 ! thiolester hydrolase activity

[Term]
id: GO:0004417
name: hydroxyethylthiazole kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphoethyl)-thiazole + ADP + 2 H(+)." [EC:2.7.1.50, RHEA:24215]
subset: gosubset_prok
synonym: "4-methyl-5-(beta-hydroxyethyl)thiazole kinase activity" EXACT [EC:2.7.1.50]
synonym: "ATP:4-methyl-5-(2-hydroxyethyl)thiazole 2-phosphotransferase activity" EXACT [EC:2.7.1.50]
synonym: "hydroxyethylthiazole kinase (phosphorylating)" EXACT [EC:2.7.1.50]
xref: EC:2.7.1.50
xref: KEGG:R04448
xref: MetaCyc:THIAZOLSYN3-RXN
xref: RHEA:24215
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0004418
name: hydroxymethylbilane synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + 4 porphobilinogen = hydroxymethylbilane + 4 NH(4)(+)." [EC:2.5.1.61, RHEA:13188]
comment: Note that this function was formerly EC:4.3.1.8.
subset: gosubset_prok
synonym: "(4-(2-carboxyethyl)-3-(carboxymethyl)pyrrol-2-yl)methyltransferase (hydrolyzing) activity" EXACT [EC:2.5.1.61]
synonym: "(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)" EXACT [EC:2.5.1.61]
synonym: "HMB-synthase activity" EXACT [EC:2.5.1.61]
synonym: "porphobilinogen ammonia-lyase (polymerizing)" EXACT [EC:2.5.1.61]
synonym: "porphobilinogen deaminase activity" EXACT [EC:2.5.1.61]
synonym: "porphobilinogen:(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)" EXACT [EC:2.5.1.61]
synonym: "pre-uroporphyrinogen synthase activity" EXACT [EC:2.5.1.61]
synonym: "uroporphyrinogen I synthase activity" NARROW [EC:2.5.1.61]
synonym: "uroporphyrinogen I synthetase activity" NARROW [EC:2.5.1.61]
synonym: "uroporphyrinogen synthase activity" EXACT [EC:2.5.1.61]
synonym: "uroporphyrinogen synthetase activity" EXACT [EC:2.5.1.61]
xref: EC:2.5.1.61
xref: KEGG:R00084
xref: MetaCyc:OHMETHYLBILANESYN-RXN
xref: Reactome:REACT_111975 "Four PBGs combine through deamination to form hydroxymethylbilane (HMB), Bos taurus"
xref: Reactome:REACT_112064 "Four PBGs combine through deamination to form hydroxymethylbilane (HMB), Mycobacterium tuberculosis"
xref: Reactome:REACT_112125 "Four PBGs combine through deamination to form hydroxymethylbilane (HMB), Xenopus tropicalis"
xref: Reactome:REACT_112182 "Four PBGs combine through deamination to form hydroxymethylbilane (HMB), Saccharomyces cerevisiae"
xref: Reactome:REACT_112379 "Four PBGs combine through deamination to form hydroxymethylbilane (HMB), Gallus gallus"
xref: Reactome:REACT_112891 "Four PBGs combine through deamination to form hydroxymethylbilane (HMB), Danio rerio"
xref: Reactome:REACT_112987 "Four PBGs combine through deamination to form hydroxymethylbilane (HMB), Escherichia coli"
xref: Reactome:REACT_113671 "Four PBGs combine through deamination to form hydroxymethylbilane (HMB), Dictyostelium discoideum"
xref: Reactome:REACT_113741 "Four PBGs combine through deamination to form hydroxymethylbilane (HMB), Oryza sativa"
xref: Reactome:REACT_113842 "Four PBGs combine through deamination to form hydroxymethylbilane (HMB), Schizosaccharomyces pombe"
xref: Reactome:REACT_113975 "Four PBGs combine through deamination to form hydroxymethylbilane (HMB), Arabidopsis thaliana"
xref: Reactome:REACT_113989 "Four PBGs combine through deamination to form hydroxymethylbilane (HMB), Mus musculus"
xref: Reactome:REACT_114353 "Four PBGs combine through deamination to form hydroxymethylbilane (HMB), Rattus norvegicus"
xref: Reactome:REACT_114418 "Four PBGs combine through deamination to form hydroxymethylbilane (HMB), Staphylococcus aureus N315"
xref: Reactome:REACT_114514 "Four PBGs combine through deamination to form hydroxymethylbilane (HMB), Plasmodium falciparum"
xref: Reactome:REACT_114679 "Four PBGs combine through deamination to form hydroxymethylbilane (HMB), Drosophila melanogaster"
xref: Reactome:REACT_114680 "Four PBGs combine through deamination to form hydroxymethylbilane (HMB), Sus scrofa"
xref: Reactome:REACT_115346 "Four PBGs combine through deamination to form hydroxymethylbilane (HMB), Canis familiaris"
xref: Reactome:REACT_116165 "4 porphobilinogen + H2O => hydroxymethylbilane + 4 NH3, Gallus gallus"
xref: Reactome:REACT_9446 "Four PBGs combine through deamination to form hydroxymethylbilane (HMB), Homo sapiens"
xref: RHEA:13188
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0004419
name: hydroxymethylglutaryl-CoA lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA." [EC:4.1.3.4, RHEA:24407]
subset: gosubset_prok
synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase (acetyl-CoA-forming)" EXACT [EC:4.1.3.4]
synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase activity" EXACT [EC:4.1.3.4]
synonym: "3-hydroxy-3-methylglutarate-CoA lyase activity" EXACT [EC:4.1.3.4]
synonym: "3-hydroxy-3-methylglutaryl CoA cleaving enzyme" RELATED [EC:4.1.3.4]
synonym: "3-hydroxy-3-methylglutaryl coenzyme A lyase activity" EXACT [EC:4.1.3.4]
synonym: "3-hydroxy-3-methylglutaryl-CoA lyase activity" EXACT [EC:4.1.3.4]
synonym: "HMG-CoA lyase activity" EXACT [EC:4.1.3.4]
synonym: "hydroxymethylglutaryl coenzyme A lyase activity" EXACT [EC:4.1.3.4]
synonym: "hydroxymethylglutaryl coenzyme A-cleaving enzyme" RELATED [EC:4.1.3.4]
xref: EC:4.1.3.4
xref: KEGG:R01360
xref: MetaCyc:HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN
xref: Reactome:REACT_100202 "HMG CoA => acetoacetic acid + acetyl CoA, Dictyostelium discoideum"
xref: Reactome:REACT_104457 "HMG CoA => acetoacetic acid + acetyl CoA, Drosophila melanogaster"
xref: Reactome:REACT_105243 "HMG CoA => acetoacetic acid + acetyl CoA, Canis familiaris"
xref: Reactome:REACT_108952 "HMG CoA => acetoacetic acid + acetyl CoA, Gallus gallus"
xref: Reactome:REACT_110966 "HMG CoA => acetoacetic acid + acetyl CoA, Arabidopsis thaliana"
xref: Reactome:REACT_2103 "HMG CoA => acetoacetic acid + acetyl CoA, Homo sapiens"
xref: Reactome:REACT_29720 "HMG CoA => acetoacetic acid + acetyl CoA, Oryza sativa"
xref: Reactome:REACT_31175 "HMG CoA => acetoacetic acid + acetyl CoA, Taeniopygia guttata"
xref: Reactome:REACT_86954 "HMG CoA => acetoacetic acid + acetyl CoA, Mus musculus"
xref: Reactome:REACT_89460 "HMG CoA => acetoacetic acid + acetyl CoA, Xenopus tropicalis"
xref: Reactome:REACT_90800 "HMG CoA => acetoacetic acid + acetyl CoA, Rattus norvegicus"
xref: Reactome:REACT_91737 "HMG CoA => acetoacetic acid + acetyl CoA, Bos taurus"
xref: Reactome:REACT_99837 "HMG CoA => acetoacetic acid + acetyl CoA, Danio rerio"
xref: Reactome:REACT_99898 "HMG CoA => acetoacetic acid + acetyl CoA, Caenorhabditis elegans"
xref: RHEA:24407
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0004420
name: hydroxymethylglutaryl-CoA reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH." [EC:1.1.1.34, RHEA:15992]
subset: gosubset_prok
synonym: "3-hydroxy-3-methylglutaryl-coenzyme A reductase activity" BROAD [EC:1.1.1.34]
synonym: "HMG-CoA reductase activity" BROAD [EC:1.1.1.34]
xref: EC:1.1.1.34
xref: KEGG:R02082
xref: MetaCyc:1.1.1.34-RXN
xref: Reactome:REACT_100813 "Reduction of HMG-CoA produces mevalonate, Arabidopsis thaliana"
xref: Reactome:REACT_103521 "Reduction of HMG-CoA produces mevalonate, Caenorhabditis elegans"
xref: Reactome:REACT_103848 "Reduction of HMG-CoA produces mevalonate, Saccharomyces cerevisiae"
xref: Reactome:REACT_105607 "Reduction of HMG-CoA produces mevalonate, Gallus gallus"
xref: Reactome:REACT_106886 "Reduction of HMG-CoA produces mevalonate, Bos taurus"
xref: Reactome:REACT_109306 "Reduction of HMG-CoA produces mevalonate, Dictyostelium discoideum"
xref: Reactome:REACT_111022 "Reduction of HMG-CoA produces mevalonate, Drosophila melanogaster"
xref: Reactome:REACT_29404 "Reduction of HMG-CoA produces mevalonate, Canis familiaris"
xref: Reactome:REACT_30181 "Reduction of HMG-CoA produces mevalonate, Taeniopygia guttata"
xref: Reactome:REACT_80613 "Reduction of HMG-CoA produces mevalonate, Mus musculus"
xref: Reactome:REACT_85139 "Reduction of HMG-CoA produces mevalonate, Xenopus tropicalis"
xref: Reactome:REACT_89068 "Reduction of HMG-CoA produces mevalonate, Schizosaccharomyces pombe"
xref: Reactome:REACT_91015 "Reduction of HMG-CoA produces mevalonate, Oryza sativa"
xref: Reactome:REACT_91582 "Reduction of HMG-CoA produces mevalonate, Danio rerio"
xref: Reactome:REACT_9482 "Reduction of HMG-CoA produces mevalonate, Homo sapiens"
xref: Reactome:REACT_97829 "Reduction of HMG-CoA produces mevalonate, Sus scrofa"
xref: Reactome:REACT_99024 "Reduction of HMG-CoA produces mevalonate, Rattus norvegicus"
xref: RHEA:15992
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004421
name: hydroxymethylglutaryl-CoA synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetoacetyl-CoA + acetyl-CoA + H(2)O = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)." [EC:2.3.3.10, RHEA:10191]
comment: Note that this function was formerly EC:4.1.3.5.
subset: gosubset_prok
synonym: "(s)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA- acetylating) activity" EXACT [EC:2.3.3.10]
synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating)" EXACT [EC:2.3.3.10]
synonym: "3-hydroxy-3-methylglutaryl CoA synthetase activity" EXACT [EC:2.3.3.10]
synonym: "3-hydroxy-3-methylglutaryl coenzyme A synthase activity" EXACT [EC:2.3.3.10]
synonym: "3-hydroxy-3-methylglutaryl coenzyme A synthetase activity" EXACT [EC:2.3.3.10]
synonym: "3-hydroxy-3-methylglutaryl-CoA synthase activity" EXACT [EC:2.3.3.10]
synonym: "3-hydroxy-3-methylglutaryl-coenzyme A synthase activity" EXACT [EC:2.3.3.10]
synonym: "acetoacetyl coenzyme A transacetase activity" EXACT [EC:2.3.3.10]
synonym: "acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)" EXACT [EC:2.3.3.10]
synonym: "beta-hydroxy-beta-methylglutaryl-CoA synthase activity" EXACT [EC:2.3.3.10]
synonym: "HMG-CoA synthase activity" EXACT [EC:2.3.3.10]
synonym: "hydroxymethylglutaryl coenzyme A synthase activity" EXACT [EC:2.3.3.10]
synonym: "hydroxymethylglutaryl coenzyme A-condensing enzyme" RELATED [EC:2.3.3.10]
synonym: "hydroxymethylglutaryl coenzyme alpha-condensing enzyme activity" EXACT [EC:2.3.3.10]
xref: EC:2.3.3.10
xref: KEGG:R01978
xref: MetaCyc:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN
xref: Reactome:REACT_101903 "Condensation of acetyl CoA with acetoacetyl CoA to form HMG-CoA, Taeniopygia guttata"
xref: Reactome:REACT_102052 "Condensation of acetyl CoA with acetoacetyl CoA to form HMG-CoA, Rattus norvegicus"
xref: Reactome:REACT_103138 "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH, Rattus norvegicus"
xref: Reactome:REACT_103948 "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH, Taeniopygia guttata"
xref: Reactome:REACT_109586 "Condensation of acetyl CoA with acetoacetyl CoA to form HMG-CoA, Arabidopsis thaliana"
xref: Reactome:REACT_1099 "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH, Homo sapiens"
xref: Reactome:REACT_110612 "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH, Dictyostelium discoideum"
xref: Reactome:REACT_28230 "Condensation of acetyl CoA with acetoacetyl CoA to form HMG-CoA, Drosophila melanogaster"
xref: Reactome:REACT_30057 "Condensation of acetyl CoA with acetoacetyl CoA to form HMG-CoA, Saccharomyces cerevisiae"
xref: Reactome:REACT_33377 "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH, Canis familiaris"
xref: Reactome:REACT_52313 "Condensation of acetyl CoA with acetoacetyl CoA to form HMG-CoA, Sus scrofa"
xref: Reactome:REACT_77956 "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH, Bos taurus"
xref: Reactome:REACT_78158 "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH, Oryza sativa"
xref: Reactome:REACT_79489 "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH, Saccharomyces cerevisiae"
xref: Reactome:REACT_80026 "Condensation of acetyl CoA with acetoacetyl CoA to form HMG-CoA, Dictyostelium discoideum"
xref: Reactome:REACT_82694 "Condensation of acetyl CoA with acetoacetyl CoA to form HMG-CoA, Gallus gallus"
xref: Reactome:REACT_83340 "Condensation of acetyl CoA with acetoacetyl CoA to form HMG-CoA, Schizosaccharomyces pombe"
xref: Reactome:REACT_85905 "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH, Sus scrofa"
xref: Reactome:REACT_88290 "Condensation of acetyl CoA with acetoacetyl CoA to form HMG-CoA, Canis familiaris"
xref: Reactome:REACT_90273 "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH, Drosophila melanogaster"
xref: Reactome:REACT_91175 "Condensation of acetyl CoA with acetoacetyl CoA to form HMG-CoA, Danio rerio"
xref: Reactome:REACT_91924 "Condensation of acetyl CoA with acetoacetyl CoA to form HMG-CoA, Staphylococcus aureus N315"
xref: Reactome:REACT_94053 "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH, Gallus gallus"
xref: Reactome:REACT_9443 "Condensation of acetyl CoA with acetoacetyl CoA to form HMG-CoA, Homo sapiens"
xref: Reactome:REACT_95812 "Condensation of acetyl CoA with acetoacetyl CoA to form HMG-CoA, Oryza sativa"
xref: Reactome:REACT_96345 "Condensation of acetyl CoA with acetoacetyl CoA to form HMG-CoA, Mus musculus"
xref: Reactome:REACT_96349 "Condensation of acetyl CoA with acetoacetyl CoA to form HMG-CoA, Bos taurus"
xref: Reactome:REACT_96512 "Condensation of acetyl CoA with acetoacetyl CoA to form HMG-CoA, Xenopus tropicalis"
xref: Reactome:REACT_97151 "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH, Staphylococcus aureus N315"
xref: Reactome:REACT_97227 "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH, Mus musculus"
xref: Reactome:REACT_97386 "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH, Arabidopsis thaliana"
xref: Reactome:REACT_99476 "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH, Schizosaccharomyces pombe"
xref: RHEA:10191
is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

[Term]
id: GO:0004422
name: hypoxanthine phosphoribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.8, GOC:curators]
subset: gosubset_prok
synonym: "6-hydroxypurine phosphoribosyltransferase activity" RELATED [EC:2.4.2.8]
synonym: "6-mercaptopurine phosphoribosyltransferase activity" RELATED [EC:2.4.2.8]
synonym: "guanine-hypoxanthine phosphoribosyltransferase activity" BROAD [EC:2.4.2.8]
synonym: "HGPRTase activity" EXACT [EC:2.4.2.8]
synonym: "HPRT" RELATED [EC:2.4.2.8]
synonym: "hypoxanthine-guanine phosphoribosyltransferase activity" BROAD [EC:2.4.2.8]
synonym: "IMP diphosphorylase activity" EXACT [EC:2.4.2.8]
synonym: "IMP pyrophosphorylase activity" EXACT [EC:2.4.2.8]
synonym: "IMP-GMP pyrophosphorylase activity" EXACT [EC:2.4.2.8]
synonym: "IMP:diphosphate phospho-D-ribosyltransferase activity" EXACT [EC:2.4.2.8]
synonym: "inosinate pyrophosphorylase activity" EXACT [EC:2.4.2.8]
synonym: "inosine 5'-phosphate pyrophosphorylase activity" EXACT [EC:2.4.2.8]
synonym: "inosinic acid pyrophosphorylase activity" EXACT [EC:2.4.2.8]
synonym: "inosinic pyrophosphorylase activity" EXACT [EC:2.4.2.8]
synonym: "purine-6-thiol phosphoribosyltransferase activity" RELATED [EC:2.4.2.8]
synonym: "Transphosphoribosidase activity" BROAD [EC:2.4.2.8]
xref: EC:2.4.2.8
xref: KEGG:R01132
xref: MetaCyc:HYPOXANPRIBOSYLTRAN-RXN
xref: Reactome:REACT_101452 "guanine or hypoxanthine + PRPP => GMP or IMP + PPi [HPRT1], Canis familiaris"
xref: Reactome:REACT_102346 "guanine or hypoxanthine + PRPP => GMP or IMP + PPi [HPRT1], Caenorhabditis elegans"
xref: Reactome:REACT_104369 "guanine or hypoxanthine + PRPP => GMP or IMP + PPi [HPRT1], Rattus norvegicus"
xref: Reactome:REACT_104500 "guanine or hypoxanthine + PRPP => GMP or IMP + PPi [HPRT1], Sus scrofa"
xref: Reactome:REACT_104785 "guanine or hypoxanthine + PRPP => GMP or IMP + PPi [HPRT1], Taeniopygia guttata"
xref: Reactome:REACT_110880 "guanine or hypoxanthine + PRPP => GMP or IMP + PPi [HPRT1], Escherichia coli"
xref: Reactome:REACT_1444 "guanine or hypoxanthine + PRPP => GMP or IMP + PPi [HPRT1], Homo sapiens"
xref: Reactome:REACT_29023 "guanine or hypoxanthine + PRPP => GMP or IMP + PPi [HPRT1], Xenopus tropicalis"
xref: Reactome:REACT_30909 "guanine or hypoxanthine + PRPP => GMP or IMP + PPi [HPRT1], Danio rerio"
xref: Reactome:REACT_31494 "guanine or hypoxanthine + PRPP => GMP or IMP + PPi [HPRT1], Bos taurus"
xref: Reactome:REACT_31788 "guanine or hypoxanthine + PRPP => GMP or IMP + PPi [HPRT1], Dictyostelium discoideum"
xref: Reactome:REACT_80175 "guanine or hypoxanthine + PRPP => GMP or IMP + PPi [HPRT1], Gallus gallus"
xref: Reactome:REACT_85512 "guanine or hypoxanthine + PRPP => GMP or IMP + PPi [HPRT1], Mycobacterium tuberculosis"
xref: Reactome:REACT_89700 "guanine or hypoxanthine + PRPP => GMP or IMP + PPi [HPRT1], Oryza sativa"
xref: Reactome:REACT_90672 "guanine or hypoxanthine + PRPP => GMP or IMP + PPi [HPRT1], Staphylococcus aureus N315"
xref: Reactome:REACT_92489 "guanine or hypoxanthine + PRPP => GMP or IMP + PPi [HPRT1], Plasmodium falciparum"
xref: Reactome:REACT_95149 "guanine or hypoxanthine + PRPP => GMP or IMP + PPi [HPRT1], Arabidopsis thaliana"
xref: Reactome:REACT_99896 "guanine or hypoxanthine + PRPP => GMP or IMP + PPi [HPRT1], Mus musculus"
xref: RHEA:17976
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0004423
name: iduronate-2-sulfatase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin." [EC:3.1.6.13]
subset: gosubset_prok
synonym: "2-sulfo-L-iduronate 2-sulfatase activity" EXACT [EC:3.1.6.13]
synonym: "chondroitinsulfatase" BROAD [EC:3.1.6.13]
synonym: "iduronate sulfatase activity" EXACT [EC:3.1.6.13]
synonym: "iduronate sulfate sulfatase activity" EXACT [EC:3.1.6.13]
synonym: "iduronate-2-sulfate sulfatase activity" EXACT [EC:3.1.6.13]
synonym: "iduronate-2-sulphatase activity" EXACT []
synonym: "iduronide-2-sulfate sulfatase activity" EXACT [EC:3.1.6.13]
synonym: "idurono-2-sulfatase activity" EXACT [EC:3.1.6.13]
synonym: "L-iduronate 2-sulfate sulfatase activity" EXACT [EC:3.1.6.13]
synonym: "L-iduronate-2-sulfate 2-sulfohydrolase activity" EXACT [EC:3.1.6.13]
synonym: "L-idurono sulfate sulfatase activity" EXACT [EC:3.1.6.13]
synonym: "L-iduronosulfatase activity" EXACT [EC:3.1.6.13]
synonym: "sulfo-L-iduronate sulfatase activity" EXACT [EC:3.1.6.13]
synonym: "sulfoiduronate sulfohydrolase activity" EXACT [EC:3.1.6.13]
xref: EC:3.1.6.13
xref: MetaCyc:3.1.6.13-RXN
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0004424
name: imidazoleglycerol-phosphate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H(2)O." [EC:4.2.1.19, RHEA:11043]
subset: gosubset_prok
synonym: "D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate hydro-lyase [3-(imidazol-4-yl)-2-oxopropyl-phosphate-forming]" RELATED [EC:4.2.1.19]
synonym: "D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate hydro-lyase activity" EXACT [EC:4.2.1.19]
synonym: "IGP dehydratase activity" EXACT [EC:4.2.1.19]
synonym: "imidazoleglycerol phosphate dehydratase activity" EXACT []
xref: EC:4.2.1.19
xref: KEGG:R03457
xref: MetaCyc:IMIDPHOSDEHYD-RXN
xref: RHEA:11043
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0004425
name: indole-3-glycerol-phosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O." [EC:4.1.1.48]
subset: gosubset_prok
synonym: "1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate carboxy-lyase (cyclizing)" EXACT [EC:4.1.1.48]
synonym: "1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate carboxy-lyase [cyclizing; 1-C-(3-indolyl)-glycerol-3-phosphate-forming]" RELATED [EC:4.1.1.48]
synonym: "indole-3-glycerophosphate synthase activity" EXACT [EC:4.1.1.48]
synonym: "indoleglycerol phosphate synthase activity" EXACT [EC:4.1.1.48]
synonym: "indoleglycerol phosphate synthetase activity" EXACT [EC:4.1.1.48]
xref: EC:4.1.1.48
xref: MetaCyc:IGPSYN-RXN
xref: RHEA:23479
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004427
name: inorganic diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: diphosphate + H(2)O = H(+) + 2 phosphate." [EC:3.6.1.1, RHEA:24579]
subset: gosubset_prok
synonym: "diphosphate phosphohydrolase activity" EXACT [EC:3.6.1.1]
synonym: "inorganic pyrophosphatase activity" EXACT [EC:3.6.1.1]
synonym: "pyrophosphate phosphohydrolase activity" EXACT [EC:3.6.1.1]
xref: EC:3.6.1.1
xref: KEGG:R00004
xref: MetaCyc:INORGPYROPHOSPHAT-RXN
xref: Reactome:REACT_102990 "pyrophosphate + H2O => 2 orthophosphate [cytosolic], Mus musculus"
xref: Reactome:REACT_103050 "pyrophosphate + H2O => 2 orthophosphate [cytosolic], Gallus gallus"
xref: Reactome:REACT_106554 "pyrophosphate + H2O => 2 orthophosphate [cytosolic], Canis familiaris"
xref: Reactome:REACT_109072 "pyrophosphate + H2O => 2 orthophosphate [cytosolic], Danio rerio"
xref: Reactome:REACT_113089 "pyrophosphate + H2O => 2 orthophosphate [cytosolic], Arabidopsis thaliana"
xref: Reactome:REACT_113725 "pyrophosphate + H2O => 2 orthophosphate [cytosolic], Mycobacterium tuberculosis"
xref: Reactome:REACT_114811 "pyrophosphate + H2O => 2 orthophosphate [cytosolic], Oryza sativa"
xref: Reactome:REACT_115460 "pyrophosphate + H2O => 2 orthophosphate [cytosolic], Plasmodium falciparum"
xref: Reactome:REACT_206 "pyrophosphate + H2O => 2 orthophosphate [cytosolic], Homo sapiens"
xref: Reactome:REACT_21277 "pyrophosphate + H2O => 2 orthophosphate [mitochondrial], Homo sapiens"
xref: Reactome:REACT_77713 "pyrophosphate + H2O => 2 orthophosphate [cytosolic], Saccharomyces cerevisiae"
xref: Reactome:REACT_80265 "pyrophosphate + H2O => 2 orthophosphate [cytosolic], Xenopus tropicalis"
xref: Reactome:REACT_80269 "pyrophosphate + H2O => 2 orthophosphate [cytosolic], Bos taurus"
xref: Reactome:REACT_85089 "pyrophosphate + H2O => 2 orthophosphate [cytosolic], Drosophila melanogaster"
xref: Reactome:REACT_87198 "pyrophosphate + H2O => 2 orthophosphate [cytosolic], Dictyostelium discoideum"
xref: Reactome:REACT_87618 "pyrophosphate + H2O => 2 orthophosphate [cytosolic], Rattus norvegicus"
xref: Reactome:REACT_87837 "pyrophosphate + H2O => 2 orthophosphate [cytosolic], Sus scrofa"
xref: Reactome:REACT_91314 "pyrophosphate + H2O => 2 orthophosphate [cytosolic], Schizosaccharomyces pombe"
xref: Reactome:REACT_92435 "pyrophosphate + H2O => 2 orthophosphate [cytosolic], Taeniopygia guttata"
xref: Reactome:REACT_95722 "pyrophosphate + H2O => 2 orthophosphate [cytosolic], Caenorhabditis elegans"
xref: RHEA:24579
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0004428
name: obsolete inositol or phosphatidylinositol kinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the phosphorylation of myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol." [GOC:hb]
comment: This term was made obsolete because it is a grouping term representing two quite different sets of entities, hexose sugars and glycerophospholipids.
synonym: "inositol or phosphatidylinositol kinase activity" EXACT []
synonym: "inositol/phosphatidylinositol kinase activity" EXACT []
is_obsolete: true
consider: GO:0016307
consider: GO:0019140
consider: GO:0052742
consider: GO:0052813

[Term]
id: GO:0004430
name: 1-phosphatidylinositol 4-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H(+)." [EC:2.7.1.67, RHEA:19880]
synonym: "ATP:1-phosphatidyl-1D-myo-inositol 4-phosphotransferase activity" EXACT [EC:2.7.1.67]
synonym: "phosphatidylinositol 4-kinase activity" BROAD [EC:2.7.1.67]
synonym: "phosphatidylinositol kinase (phosphorylating) activity" BROAD [EC:2.7.1.67]
synonym: "phosphatidylinositol kinase activity" BROAD [EC:2.7.1.67]
synonym: "PI 4-kinase activity" EXACT [EC:2.7.1.67]
synonym: "PI kinase activity" BROAD [EC:2.7.1.67]
synonym: "PI4-kinase activity" BROAD [EC:2.7.1.67]
synonym: "PI4K" BROAD [EC:2.7.1.67]
synonym: "PI4K-alpha activity" BROAD [EC:2.7.1.67]
synonym: "PtdIns-4-kinase activity" BROAD [EC:2.7.1.67]
synonym: "type II phosphatidylinositol kinase activity" RELATED [EC:2.7.1.67]
xref: EC:2.7.1.67
xref: KEGG:R03361
xref: MetaCyc:1-PHOSPHATIDYLINOSITOL-KINASE-RXN
xref: RHEA:19880
is_a: GO:0052742 ! phosphatidylinositol kinase activity

[Term]
id: GO:0004432
name: obsolete 1-phosphatidylinositol-4-phosphate kinase, class IA
namespace: molecular_function
def: "OBSOLETE. A class I PI3K activated by tyrosine phosphorylation events." [PMID:11050418]
comment: This term was made obsolete because it is not a valid molecular function.
synonym: "1-phosphatidylinositol-4-phosphate kinase, class IA" EXACT []
is_obsolete: true
consider: GO:0016308

[Term]
id: GO:0004433
name: obsolete 1-phosphatidylinositol-4-phosphate kinase, class IB
namespace: molecular_function
def: "OBSOLETE. A class I PI3K activated via heterotrimeric G-proteins." [PMID:11050418]
comment: This term was made obsolete because it is not a valid molecular function.
synonym: "1-phosphatidylinositol-4-phosphate kinase, class IB" EXACT []
is_obsolete: true
consider: GO:0016308

[Term]
id: GO:0004435
name: phosphatidylinositol phospholipase C activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+)." [EC:3.1.4.11, RHEA:23915]
subset: gosubset_prok
synonym: "1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity" EXACT [EC:3.1.4.11]
synonym: "1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity" EXACT [EC:3.1.4.11]
synonym: "1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase activity" EXACT []
synonym: "monophosphatidylinositol phosphodiesterase activity" BROAD [EC:3.1.4.11]
synonym: "phosphatidylinositol-4,5-bisphosphate hydrolysis" RELATED []
synonym: "phosphoinositidase C activity" EXACT [EC:3.1.4.11]
synonym: "phosphoinositide phospholipase C activity" EXACT [EC:3.1.4.11]
synonym: "PI-PLC activity" EXACT [EC:3.1.4.11]
synonym: "triphosphoinositide phosphodiesterase activity" BROAD [EC:3.1.4.11]
xref: EC:3.1.4.11
xref: KEGG:R03435
xref: MetaCyc:3.1.4.11-RXN
xref: Reactome:REACT_100549 "PLC-gamma1 hydrolyses PIP2, Danio rerio"
xref: Reactome:REACT_101538 "PIP2 hydrolysis, Taeniopygia guttata"
xref: Reactome:REACT_103918 "PIP2 hydrolysis, Xenopus tropicalis"
xref: Reactome:REACT_104013 "PIP2 hydrolysis, Caenorhabditis elegans"
xref: Reactome:REACT_104384 "PLC-gamma1 hydrolyses PIP2, Sus scrofa"
xref: Reactome:REACT_105056 "PIP2 hydrolysis, Canis familiaris"
xref: Reactome:REACT_105753 "PLC-gamma1 hydrolyses PIP2, Gallus gallus"
xref: Reactome:REACT_106433 "PLC-gamma1 hydrolyses PIP2, Rattus norvegicus"
xref: Reactome:REACT_107694 "PIP2 hydrolysis, Gallus gallus"
xref: Reactome:REACT_108661 "PIP2 hydrolysis, Mus musculus"
xref: Reactome:REACT_109774 "Active PLCG1 hydrolyses PIP2, Danio rerio"
xref: Reactome:REACT_111977 "PIP2 hydrolysis, Drosophila melanogaster"
xref: Reactome:REACT_112016 "Active PLCG1 hydrolyses PIP2, Arabidopsis thaliana"
xref: Reactome:REACT_112120 "PLC-gamma1 hydrolyses PIP2, Saccharomyces cerevisiae"
xref: Reactome:REACT_112432 "PLC-gamma1 hydrolyses PIP2, Oryza sativa"
xref: Reactome:REACT_112586 "PIP2 hydrolysis, Oryza sativa"
xref: Reactome:REACT_113026 "PLC-gamma1 hydrolyses PIP2, Drosophila melanogaster"
xref: Reactome:REACT_113134 "PIP2 hydrolysis, Schizosaccharomyces pombe"
xref: Reactome:REACT_113176 "PLC-gamma1 hydrolyses PIP2, Arabidopsis thaliana"
xref: Reactome:REACT_113179 "Active PLCG1 hydrolyses PIP2, Saccharomyces cerevisiae"
xref: Reactome:REACT_113201 "PLC-gamma1 hydrolyses PIP2, Plasmodium falciparum"
xref: Reactome:REACT_113580 "PLC-gamma1 hydrolyses PIP2, Dictyostelium discoideum"
xref: Reactome:REACT_113618 "Active PLCG1 hydrolyses PIP2, Plasmodium falciparum"
xref: Reactome:REACT_113733 "Active PLCG1 hydrolyses PIP2, Dictyostelium discoideum"
xref: Reactome:REACT_113827 "PIP2 hydrolysis, Dictyostelium discoideum"
xref: Reactome:REACT_113870 "PLC-gamma1 hydrolyses PIP2, Schizosaccharomyces pombe"
xref: Reactome:REACT_113925 "Active PLCG1 hydrolyses PIP2, Drosophila melanogaster"
xref: Reactome:REACT_113959 "PIP2 hydrolysis, Arabidopsis thaliana"
xref: Reactome:REACT_114034 "PIP2 hydrolysis, Schizosaccharomyces pombe"
xref: Reactome:REACT_114083 "Active PLCG1 hydrolyses PIP2, Oryza sativa"
xref: Reactome:REACT_114101 "PLC-gamma1 hydrolyses PIP2, Caenorhabditis elegans"
xref: Reactome:REACT_114237 "Active PLCG1 hydrolyses PIP2, Caenorhabditis elegans"
xref: Reactome:REACT_114264 "Active PLCG1 hydrolyses PIP2, Schizosaccharomyces pombe"
xref: Reactome:REACT_114329 "PIP2 hydrolysis, Dictyostelium discoideum"
xref: Reactome:REACT_114608 "PIP2 hydrolysis, Saccharomyces cerevisiae"
xref: Reactome:REACT_114663 "PIP2 hydrolysis, Plasmodium falciparum"
xref: Reactome:REACT_114783 "PIP2 hydrolysis, Caenorhabditis elegans"
xref: Reactome:REACT_115119 "PIP2 hydrolysis, Saccharomyces cerevisiae"
xref: Reactome:REACT_116048 "Active PLCG1 hydrolyses PIP2, Rattus norvegicus"
xref: Reactome:REACT_12078 "Active PLCG1 hydrolyses PIP2, Homo sapiens"
xref: Reactome:REACT_12585 "PLC-gamma1 hydrolyses PIP2, Homo sapiens"
xref: Reactome:REACT_15353 "PIP2 hydrolysis, Homo sapiens"
xref: Reactome:REACT_22318 "PIP2 hydrolysis, Homo sapiens"
xref: Reactome:REACT_22417 "PIP2 hydrolysis, Rattus norvegicus"
xref: Reactome:REACT_28616 "PLC-gamma1 hydrolyses PIP2, Xenopus tropicalis"
xref: Reactome:REACT_31243 "PLC-gamma1 hydrolyses PIP2, Taeniopygia guttata"
xref: Reactome:REACT_34289 "PIP2 hydrolysis, Sus scrofa"
xref: Reactome:REACT_77907 "PIP2 hydrolysis, Danio rerio"
xref: Reactome:REACT_79438 "PIP2 hydrolysis, Bos taurus"
xref: Reactome:REACT_80615 "Active PLCG1 hydrolyses PIP2, Mus musculus"
xref: Reactome:REACT_80913 "Active PLCG1 hydrolyses PIP2, Gallus gallus"
xref: Reactome:REACT_82046 "PIP2 hydrolysis, Danio rerio"
xref: Reactome:REACT_84690 "Active PLCG1 hydrolyses PIP2, Bos taurus"
xref: Reactome:REACT_86163 "PLC-gamma1 hydrolyses PIP2, Bos taurus"
xref: Reactome:REACT_86182 "PLC-gamma1 hydrolyses PIP2, Mus musculus"
xref: Reactome:REACT_87086 "PIP2 hydrolysis, Taeniopygia guttata"
xref: Reactome:REACT_87142 "PIP2 hydrolysis, Bos taurus"
xref: Reactome:REACT_87357 "PIP2 hydrolysis, Mus musculus"
xref: Reactome:REACT_87628 "PIP2 hydrolysis, Drosophila melanogaster"
xref: Reactome:REACT_87970 "Active PLCG1 hydrolyses PIP2, Sus scrofa"
xref: Reactome:REACT_88756 "PIP2 hydrolysis, Xenopus tropicalis"
xref: Reactome:REACT_88910 "Active PLCG1 hydrolyses PIP2, Taeniopygia guttata"
xref: Reactome:REACT_90807 "PIP2 hydrolysis, Sus scrofa"
xref: Reactome:REACT_93506 "Active PLCG1 hydrolyses PIP2, Xenopus tropicalis"
xref: Reactome:REACT_94845 "PIP2 hydrolysis, Rattus norvegicus"
xref: Reactome:REACT_97327 "Active PLCG1 hydrolyses PIP2, Canis familiaris"
xref: Reactome:REACT_97840 "PIP2 hydrolysis, Canis familiaris"
xref: Reactome:REACT_98877 "PIP2 hydrolysis, Gallus gallus"
xref: Reactome:REACT_99371 "PLC-gamma1 hydrolyses PIP2, Canis familiaris"
xref: RHEA:23915
is_a: GO:0004629 ! phospholipase C activity

[Term]
id: GO:0004436
name: phosphatidylinositol diacylglycerol-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol = D-myo-inositol 1,2-cyclic phosphate + diacylglycerol." [EC:4.6.1.13]
comment: Note that this function was formerly EC:3.1.4.10.
subset: gosubset_prok
synonym: "1-phosphatidyl-1D-myo-inositol diacyl-sn-glycerol-lyase (1D-myo-inositol-1,2-cyclic-phosphate-forming)" EXACT [EC:4.6.1.13]
synonym: "1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase (1,2-cyclic-phosphate-forming)" EXACT [EC:4.6.1.13]
synonym: "1-phosphatidyl-D-myo-inositol inositolphosphohydrolase (cyclic-phosphate-forming)" EXACT [EC:4.6.1.13]
synonym: "1-phosphatidylinositol phosphodiesterase activity" EXACT []
synonym: "monophosphatidylinositol phosphodiesterase activity" BROAD [EC:4.6.1.13]
xref: EC:4.6.1.13
xref: MetaCyc:3.1.4.10-RXN
xref: RHEA:17096
is_a: GO:0016849 ! phosphorus-oxygen lyase activity

[Term]
id: GO:0004437
name: obsolete inositol or phosphatidylinositol phosphatase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the removal of a phosphate group from phosphorylated myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol." [GOC:hb]
comment: This term was made obsolete because it is a grouping term representing two quite different sets of entities, hexose sugars and glycerophospholipids.
synonym: "inositol or phosphatidylinositol phosphatase activity" EXACT []
synonym: "inositol/phosphatidylinositol phosphatase activity" EXACT []
is_obsolete: true
consider: GO:0034593
consider: GO:0034594
consider: GO:0052744
consider: GO:0052745

[Term]
id: GO:0004438
name: phosphatidylinositol-3-phosphatase activity
namespace: molecular_function
alt_id: GO:0016315
def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate." [EC:3.1.3.64]
comment: Note that this function includes EC:3.1.3.65.
synonym: "1-phosphatidyl-1D-myo-inositol-3-phosphate 3-phosphohydrolase activity" EXACT [EC:3.1.3.64]
synonym: "D-myo-inositol-1,3-bisphosphate 3-phosphohydrolase activity" EXACT [EC:3.1.3.64]
synonym: "inositol 1,3-bisphosphate phosphatase activity" EXACT [EC:3.1.3.64]
synonym: "inositol-1,3-bisphosphate 3-phosphatase activity" EXACT [EC:3.1.3.64]
synonym: "inositol-1,4,-bisphosphate 3-phosphatase activity" EXACT []
synonym: "inositol-polyphosphate 3-phosphatase activity" EXACT [EC:3.1.3.64]
synonym: "phosphatidyl-3-phosphate 3-phosphohydrolase activity" EXACT [EC:3.1.3.64]
xref: EC:3.1.3.64
xref: MetaCyc:PHOSPHATIDYLINOSITOL-3-PHOSPHATASE-RXN
xref: RHEA:12319
is_a: GO:0052744 ! phosphatidylinositol monophosphate phosphatase activity

[Term]
id: GO:0004439
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
namespace: molecular_function
alt_id: GO:0001668
def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate." [EC:3.1.3.36, RHEA:22767]
synonym: "phosphatidyl-myo-inositol-4,5-bisphosphate phosphatase activity" EXACT [EC:3.1.3.36]
synonym: "phosphatidylinositol 4,5-bisphosphate phosphatase activity" BROAD [EC:3.1.3.36]
synonym: "phosphatidylinositol-bisphosphatase activity" BROAD [EC:3.1.3.36]
synonym: "PtdIns(4,5)P(2) phosphatase activity" EXACT [EC:3.1.3.36]
synonym: "PtdIns(4,5)P2 phosphatase activity" EXACT [EC:3.1.3.36]
synonym: "triphosphoinositide phosphatase activity" BROAD [EC:3.1.3.36]
synonym: "triphosphoinositide phosphomonoesterase activity" BROAD [EC:3.1.3.36]
xref: EC:3.1.3.36
xref: KEGG:R04404
xref: MetaCyc:PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN
xref: RHEA:22767
is_a: GO:0034593 ! phosphatidylinositol bisphosphate phosphatase activity
is_a: GO:0034595 ! phosphatidylinositol phosphate 5-phosphatase activity

[Term]
id: GO:0004441
name: inositol-1,4-bisphosphate 1-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate." [EC:3.1.3.57, GOC:hb]
synonym: "1D-myo-inositol-1,4-bisphosphate 1-phosphohydrolase activity" EXACT [EC:3.1.3.57]
synonym: "inositol polyphosphate 1-phosphatase activity" BROAD [EC:3.1.3.57]
synonym: "inositol-polyphosphate 1-phosphatase activity" EXACT [EC:3.1.3.57]
xref: EC:3.1.3.57
xref: MetaCyc:3.1.3.57-RXN
xref: RHEA:15556
is_a: GO:0016312 ! inositol bisphosphate phosphatase activity

[Term]
id: GO:0004442
name: obsolete inositol-1,4,-bisphosphate 3-phosphatase
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: D-myo-inositol 1,3-bisphosphate + H2O = D-myo-inositol 1-monophosphate + phosphate." [EC:3.1.3.65, GOC:go_curators]
synonym: "inositol-1,4,-bisphosphate 3-phosphatase" EXACT []
is_obsolete: true
consider: GO:0004438

[Term]
id: GO:0004443
name: obsolete inositol-1,4,-bisphosphate 4-phosphatase
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: D-myo-inositol 3,4-bisphosphate + H2O = D-myo-inositol 3-monophosphate + phosphate." [EC:3.1.3.66, GOC:go_curators]
synonym: "inositol-1,4,-bisphosphate 4-phosphatase" EXACT []
is_obsolete: true
consider: GO:0016316

[Term]
id: GO:0004444
name: obsolete inositol-1,4,5-trisphosphate 1-phosphatase
namespace: molecular_function
def: "OBSOLETE. The removal of a phosphate group from the carbon-1 position of D-myo-inositol 1,4,5-trisphosphate." [EC:3.1.3.61, GOC:hb]
comment: This term was made obsolete because the existence of this function has not been established.
synonym: "inositol-1,4,5-trisphosphate 1-phosphatase" EXACT []
is_obsolete: true
consider: GO:0046030

[Term]
id: GO:0004445
name: inositol-polyphosphate 5-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate." [EC:3.1.3.56]
comment: Note that this is a compound function and should be replaced by 'GO:0052659 : inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity' and 'GO:0052658 : inositol-1,4,5-trisphosphate 5-phosphatase activity'.
synonym: "1D-myo-inositol-1,4,5-trisphosphate 5-phosphohydrolase activity" NARROW [EC:3.1.3.56]
synonym: "5PTase activity" RELATED [EC:3.1.3.56]
synonym: "D-myo-inositol 1,4,5-triphosphate 5-phosphatase activity" NARROW [EC:3.1.3.56]
synonym: "D-myo-inositol 1,4,5-trisphosphate 5-phosphatase activity" NARROW [EC:3.1.3.56]
synonym: "D-myo-inositol(1,4,5)/(1,3,4,5)-polyphosphate 5-phosphatase activity" EXACT [EC:3.1.3.56]
synonym: "inosine triphosphatase activity" RELATED [EC:3.1.3.56]
synonym: "inositol 1,4,5-trisphosphate phosphatase activity" BROAD [EC:3.1.3.56]
synonym: "inositol phosphate 5-phosphomonoesterase activity" BROAD [EC:3.1.3.56]
synonym: "inositol polyphosphate-5-phosphatase activity" EXACT [EC:3.1.3.56]
synonym: "inositol triphosphate 5-phosphomonoesterase activity" RELATED []
synonym: "inositol trisphosphate phosphomonoesterase activity" RELATED [EC:3.1.3.56]
synonym: "inositol-1,4,5-trisphosphate 5-phosphatase activity" NARROW []
synonym: "inositol-1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase activity" EXACT [EC:3.1.3.56]
synonym: "Ins(1,4,5)P(3) 5-phosphatase activity" NARROW [EC:3.1.3.56]
synonym: "Ins(1,4,5)P3 5-phosphatase activity" NARROW [EC:3.1.3.56]
synonym: "Ins(1,4,5)P3/Ins(1,3,4,5)P4 5-phosphatase activity" EXACT [EC:3.1.3.56]
synonym: "InsP(3)/Ins(1,3,4,5)P(4) 5-phosphatase activity" NARROW [EC:3.1.3.56]
synonym: "InsP3/Ins(1,3,4,5)P4 5-phosphatase activity" NARROW [EC:3.1.3.56]
synonym: "L-myo-inositol 1,4,5-trisphosphate-monoesterase activity" BROAD [EC:3.1.3.56]
synonym: "myo-inositol-1,4,5-trisphosphate 5-phosphatase activity" NARROW [EC:3.1.3.56]
synonym: "type I inositol-polyphosphate phosphatase activity" RELATED [EC:3.1.3.56]
synonym: "type II inositol polyphosphate 5-phosphatase activity" RELATED []
synonym: "type II inositol-1,4,5-trisphosphate 5-phosphatase activity" NARROW []
xref: EC:3.1.3.56
is_a: GO:0046030 ! inositol trisphosphate phosphatase activity

[Term]
id: GO:0004446
name: inositol-hexakisphosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = myo-inositol pentakisphosphate (mixed isomers) + phosphate." [EC:3.1.3.62]
synonym: "1D-myo-inositol-hexakisphosphate 5-phosphohydrolase activity" NARROW [EC:3.1.3.62]
synonym: "inositol tetrakisphosphate phosphomonoesterase activity" RELATED [EC:3.1.3.62]
synonym: "MIPP activity" BROAD [EC:3.1.3.62]
synonym: "multiple inositol-polyphosphate phosphatase activity" BROAD [EC:3.1.3.62]
xref: EC:3.1.3.62
xref: MetaCyc:RXN-7920
is_a: GO:0052745 ! inositol phosphate phosphatase activity

[Term]
id: GO:0004447
name: iodide peroxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: iodide + hydrogen peroxide = iodine + 2 H2O." [EC:1.11.1.8]
synonym: "iodide peroxidase-tyrosine iodinase activity" EXACT [EC:1.11.1.8]
synonym: "iodide:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.8]
synonym: "iodinase activity" RELATED [EC:1.11.1.8]
synonym: "iodoperoxidase (heme type)" EXACT [EC:1.11.1.8]
synonym: "iodotyrosine deiodase activity" EXACT [EC:1.11.1.8]
synonym: "iodotyrosine deiodinase activity" EXACT [EC:1.11.1.8]
synonym: "monoiodotyrosine deiodinase activity" EXACT [EC:1.11.1.8]
synonym: "thyroid peroxidase activity" RELATED [EC:1.11.1.8]
synonym: "thyroperoxidase activity" RELATED [EC:1.11.1.8]
synonym: "TPO activity" RELATED [EC:1.11.1.8]
synonym: "tyrosine iodinase activity" EXACT [EC:1.11.1.8]
xref: EC:1.11.1.8
xref: MetaCyc:IODIDE-PEROXIDASE-RXN
xref: RHEA:23339
is_a: GO:0004601 ! peroxidase activity

[Term]
id: GO:0004448
name: isocitrate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: isocitrate + acceptor = 2-oxoglutarate + CO2 + reduced acceptor." [EC:1.1.1.41, EC:1.1.1.42]
subset: gosubset_prok
synonym: "beta-ketoglutaric-isocitric carboxylase activity" EXACT [EC:1.1.1.-]
synonym: "IDH activity" EXACT [EC:1.1.1.-]
synonym: "IDP activity" EXACT [EC:1.1.1.-]
synonym: "IDP1" RELATED [EC:1.1.1.-]
synonym: "IDP2" RELATED [EC:1.1.1.-]
synonym: "IDP3" RELATED [EC:1.1.1.-]
synonym: "isocitric acid dehydrogenase activity" EXACT [EC:1.1.1.-]
synonym: "isocitric dehydrogenase activity" EXACT [EC:1.1.1.-]
synonym: "oxalosuccinate carboxylase activity" EXACT [EC:1.1.1.-]
synonym: "oxalosuccinate decarboxylase activity" EXACT [EC:1.1.1.-]
synonym: "oxalsuccinic decarboxylase activity" EXACT [EC:1.1.1.-]
xref: EC:1.1.1.-
xref: MetaCyc:ISOCITDEH-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004449
name: isocitrate dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH + H+." [EC:1.1.1.41]
subset: gosubset_prok
synonym: "isocitrate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.41]
synonym: "isocitrate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.41]
synonym: "NAD dependent isocitrate dehydrogenase activity" EXACT [EC:1.1.1.41]
synonym: "NAD isocitrate dehydrogenase activity" EXACT [EC:1.1.1.41]
synonym: "NAD isocitric dehydrogenase activity" EXACT [EC:1.1.1.41]
synonym: "NAD-linked isocitrate dehydrogenase activity" EXACT [EC:1.1.1.41]
synonym: "NAD-specific isocitrate dehydrogenase activity" EXACT [EC:1.1.1.41]
synonym: "nicotinamide adenine dinucleotide isocitrate dehydrogenase activity" EXACT [EC:1.1.1.41]
xref: EC:1.1.1.41
xref: MetaCyc:ISOCITRATE-DEHYDROGENASE-NAD+-RXN
xref: Reactome:REACT_103757 "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3], Xenopus tropicalis"
xref: Reactome:REACT_104411 "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3], Mus musculus"
xref: Reactome:REACT_105047 "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3], Caenorhabditis elegans"
xref: Reactome:REACT_1068 "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3], Homo sapiens"
xref: Reactome:REACT_112010 "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3], Bos taurus"
xref: Reactome:REACT_113241 "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3], Canis familiaris"
xref: Reactome:REACT_115988 "isocitrate + NAD+ => 2-oxoglutarate (alpha-ketoglutarate) + CO2 + NADH + H+, Gallus gallus"
xref: Reactome:REACT_33751 "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3], Dictyostelium discoideum"
xref: Reactome:REACT_34198 "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3], Arabidopsis thaliana"
xref: Reactome:REACT_34664 "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3], Danio rerio"
xref: Reactome:REACT_78963 "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3], Drosophila melanogaster"
xref: Reactome:REACT_81678 "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3], Oryza sativa"
xref: Reactome:REACT_86659 "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3], Schizosaccharomyces pombe"
xref: Reactome:REACT_90578 "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3], Saccharomyces cerevisiae"
xref: Reactome:REACT_91953 "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3], Rattus norvegicus"
xref: Reactome:REACT_98704 "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3], Sus scrofa"
xref: RHEA:23635
is_a: GO:0004448 ! isocitrate dehydrogenase activity

[Term]
id: GO:0004450
name: isocitrate dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH + H+." [EC:1.1.1.42]
subset: gosubset_prok
synonym: "dual-cofactor-specific isocitrate dehydrogenase activity" RELATED [EC:1.1.1.42]
synonym: "isocitrate (NADP) dehydrogenase activity" EXACT [EC:1.1.1.42]
synonym: "isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT [EC:1.1.1.42]
synonym: "isocitrate dehydrogenase (NADP) activity" EXACT [EC:1.1.1.42]
synonym: "isocitrate dehydrogenase (NADP-dependent) activity" EXACT [EC:1.1.1.42]
synonym: "isocitrate:NADP+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.42]
synonym: "NADP isocitric dehydrogenase activity" EXACT [EC:1.1.1.42]
synonym: "NADP(+)-ICDH activity" EXACT [EC:1.1.1.42]
synonym: "NADP(+)-IDH activity" EXACT [EC:1.1.1.42]
synonym: "NADP(+)-linked isocitrate dehydrogenase activity" EXACT [EC:1.1.1.42]
synonym: "NADP-dependent isocitrate dehydrogenase activity" EXACT [EC:1.1.1.42]
synonym: "NADP-dependent isocitric dehydrogenase activity" EXACT [EC:1.1.1.42]
synonym: "NADP-linked isocitrate dehydrogenase activity" EXACT [EC:1.1.1.42]
synonym: "NADP-specific isocitrate dehydrogenase activity" EXACT [EC:1.1.1.42]
synonym: "triphosphopyridine nucleotide-linked isocitrate dehydrogenase activity" RELATED [EC:1.1.1.42]
xref: EC:1.1.1.42
xref: MetaCyc:ISOCITDEH-RXN
xref: Reactome:REACT_104086 "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+, Gallus gallus"
xref: Reactome:REACT_104798 "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+, Rattus norvegicus"
xref: Reactome:REACT_104821 "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+, Mycobacterium tuberculosis"
xref: Reactome:REACT_104832 "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+, Dictyostelium discoideum"
xref: Reactome:REACT_104911 "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+, Taeniopygia guttata"
xref: Reactome:REACT_106443 "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+, Drosophila melanogaster"
xref: Reactome:REACT_108800 "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+, Mus musculus"
xref: Reactome:REACT_112251 "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+, Plasmodium falciparum"
xref: Reactome:REACT_112495 "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+, Oryza sativa"
xref: Reactome:REACT_113535 "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+, Arabidopsis thaliana"
xref: Reactome:REACT_114848 "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+, Arabidopsis thaliana"
xref: Reactome:REACT_115223 "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+, Plasmodium falciparum"
xref: Reactome:REACT_115270 "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+, Oryza sativa"
xref: Reactome:REACT_16932 "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+, Homo sapiens"
xref: Reactome:REACT_17007 "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+, Homo sapiens"
xref: Reactome:REACT_21355 "isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2], Homo sapiens"
xref: Reactome:REACT_28361 "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+, Mus musculus"
xref: Reactome:REACT_31019 "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+, Saccharomyces cerevisiae"
xref: Reactome:REACT_78326 "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+, Danio rerio"
xref: Reactome:REACT_81511 "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+, Caenorhabditis elegans"
xref: Reactome:REACT_82608 "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+, Gallus gallus"
xref: Reactome:REACT_83142 "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+, Canis familiaris"
xref: Reactome:REACT_83540 "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+, Bos taurus"
xref: Reactome:REACT_83832 "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+, Taeniopygia guttata"
xref: Reactome:REACT_85281 "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+, Saccharomyces cerevisiae"
xref: Reactome:REACT_85959 "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+, Canis familiaris"
xref: Reactome:REACT_86187 "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+, Xenopus tropicalis"
xref: Reactome:REACT_86321 "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+, Dictyostelium discoideum"
xref: Reactome:REACT_86533 "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+, Drosophila melanogaster"
xref: Reactome:REACT_87891 "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+, Bos taurus"
xref: Reactome:REACT_91253 "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+, Rattus norvegicus"
xref: Reactome:REACT_91802 "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+, Schizosaccharomyces pombe"
xref: Reactome:REACT_93164 "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+, Xenopus tropicalis"
xref: Reactome:REACT_94125 "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+, Danio rerio"
xref: Reactome:REACT_94261 "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+, Schizosaccharomyces pombe"
xref: Reactome:REACT_98690 "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+, Caenorhabditis elegans"
xref: RHEA:19632
is_a: GO:0004448 ! isocitrate dehydrogenase activity

[Term]
id: GO:0004451
name: isocitrate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: isocitrate = glyoxylate + succinate." [EC:4.1.3.1, RHEA:13248]
subset: gosubset_prok
synonym: "ICL activity" EXACT [EC:4.1.3.1]
synonym: "isocitrase activity" EXACT [EC:4.1.3.1]
synonym: "isocitratase activity" EXACT [EC:4.1.3.1]
synonym: "isocitrate glyoxylate-lyase (succinate-forming)" EXACT [EC:4.1.3.1]
synonym: "isocitrate glyoxylate-lyase activity" EXACT [EC:4.1.3.1]
synonym: "isocitritase activity" EXACT [EC:4.1.3.1]
synonym: "threo-DS-isocitrate glyoxylate-lyase activity" EXACT [EC:4.1.3.1]
xref: EC:4.1.3.1
xref: KEGG:R00479
xref: MetaCyc:ISOCIT-CLEAV-RXN
xref: RHEA:13248
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0004452
name: isopentenyl-diphosphate delta-isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: isopentenyl diphosphate = dimethylallyl diphosphate." [EC:5.3.3.2, RHEA:23287]
subset: gosubset_prok
synonym: "IPP isomerase activity" EXACT [EC:5.3.3.2]
synonym: "isopentenyl-diphosphate D-isomerase activity" EXACT []
synonym: "isopentenyl-diphosphate delta3-delta2-isomerase activity" EXACT [EC:5.3.3.2]
synonym: "isopentenylpyrophosphate delta-isomerase activity" EXACT [EC:5.3.3.2]
synonym: "isopentenylpyrophosphate isomerase activity" EXACT [EC:5.3.3.2]
synonym: "methylbutenylpyrophosphate isomerase activity" EXACT [EC:5.3.3.2]
xref: EC:5.3.3.2
xref: KEGG:R01123
xref: MetaCyc:IPPISOM-RXN
xref: Reactome:REACT_102787 "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate, Escherichia coli"
xref: Reactome:REACT_108635 "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate, Taeniopygia guttata"
xref: Reactome:REACT_110091 "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate, Rattus norvegicus"
xref: Reactome:REACT_34029 "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate, Danio rerio"
xref: Reactome:REACT_39733 "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_78972 "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate, Caenorhabditis elegans"
xref: Reactome:REACT_83548 "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate, Mycobacterium tuberculosis"
xref: Reactome:REACT_84241 "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate, Drosophila melanogaster"
xref: Reactome:REACT_86017 "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate, Bos taurus"
xref: Reactome:REACT_89273 "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate, Xenopus tropicalis"
xref: Reactome:REACT_90239 "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate, Oryza sativa"
xref: Reactome:REACT_91068 "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate, Gallus gallus"
xref: Reactome:REACT_92472 "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_9517 "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate, Homo sapiens"
xref: Reactome:REACT_97232 "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate, Arabidopsis thaliana"
xref: Reactome:REACT_98735 "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_99205 "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate, Mus musculus"
xref: RHEA:23287
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0004453
name: juvenile-hormone esterase activity
namespace: molecular_function
def: "Catalysis of the reaction: methyl (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + H2O = (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + methanol. A carboxylesterase that hydrolyzes the ester linkage of juvenile hormone." [EC:3.1.1.59, EMBL:AF304352]
subset: goslim_chembl
synonym: "JH esterase activity" EXACT [EC:3.1.1.59]
synonym: "JH-esterase activity" EXACT [EC:3.1.1.59]
synonym: "juvenile hormone analog esterase activity" EXACT [EC:3.1.1.59]
synonym: "juvenile hormone carboxyesterase activity" EXACT [EC:3.1.1.59]
synonym: "methyl-(2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate acylhydrolase activity" EXACT [EC:3.1.1.59]
xref: EC:3.1.1.59
xref: MetaCyc:JUVENILE-HORMONE-ESTERASE-RXN
xref: RHEA:16396
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0004454
name: ketohexokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 1-phosphate." [EC:2.7.1.3]
subset: gosubset_prok
synonym: "ATP:D-fructose 1-phosphotransferase activity" EXACT [EC:2.7.1.3]
synonym: "hepatic fructokinase activity" NARROW [EC:2.7.1.3]
synonym: "ketohexokinase (phosphorylating)" EXACT [EC:2.7.1.3]
xref: EC:2.7.1.3
xref: MetaCyc:KETOHEXOKINASE-RXN
xref: Reactome:REACT_101082 "ATP + beta-D-fructose => ADP + D-fructose 1-phosphate, Drosophila melanogaster"
xref: Reactome:REACT_110931 "ATP + beta-D-fructose => ADP + D-fructose 1-phosphate, Arabidopsis thaliana"
xref: Reactome:REACT_1927 "ATP + beta-D-fructose => ADP + D-fructose 1-phosphate, Homo sapiens"
xref: Reactome:REACT_28411 "ATP + beta-D-fructose => ADP + D-fructose 1-phosphate, Oryza sativa"
xref: Reactome:REACT_82053 "ATP + beta-D-fructose => ADP + D-fructose 1-phosphate, Danio rerio"
xref: Reactome:REACT_85703 "ATP + beta-D-fructose => ADP + D-fructose 1-phosphate, Bos taurus"
xref: Reactome:REACT_87215 "ATP + beta-D-fructose => ADP + D-fructose 1-phosphate, Sus scrofa"
xref: Reactome:REACT_94196 "ATP + beta-D-fructose => ADP + D-fructose 1-phosphate, Mus musculus"
xref: Reactome:REACT_95161 "ATP + beta-D-fructose => ADP + D-fructose 1-phosphate, Rattus norvegicus"
xref: Reactome:REACT_95975 "ATP + beta-D-fructose => ADP + D-fructose 1-phosphate, Canis familiaris"
xref: Reactome:REACT_99716 "ATP + beta-D-fructose => ADP + D-fructose 1-phosphate, Xenopus tropicalis"
xref: RHEA:18148
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0004455
name: ketol-acid reductoisomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+." [EC:1.1.1.86]
subset: gosubset_prok
synonym: "(R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing)" EXACT [EC:1.1.1.86]
synonym: "2-hydroxy-3-keto acid reductoisomerase activity" EXACT [EC:1.1.1.86]
synonym: "acetohydroxy acid isomeroreductase activity" EXACT [EC:1.1.1.86]
synonym: "acetohydroxy acid reductoisomerase activity" EXACT [EC:1.1.1.86]
synonym: "acetolactate reductoisomerase activity" EXACT [EC:1.1.1.86]
synonym: "alpha-keto-beta-hydroxylacyl reductoisomerase activity" EXACT [EC:1.1.1.86]
synonym: "dihydroxyisovalerate (isomerizing) dehydrogenase activity" EXACT [EC:1.1.1.86]
synonym: "dihydroxyisovalerate dehydrogenase (isomerizing) activity" EXACT [EC:1.1.1.86]
synonym: "isomeroreductase activity" EXACT [EC:1.1.1.86]
synonym: "ketol acid reductoisomerase activity" EXACT [EC:1.1.1.86]
synonym: "reductoisomerase activity" EXACT [EC:1.1.1.86]
xref: EC:1.1.1.86
xref: MetaCyc:ACETOLACTREDUCTOISOM-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004456
name: phosphogluconate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-phospho-D-gluconate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + H(2)O." [EC:4.2.1.12, RHEA:17280]
subset: gosubset_prok
synonym: "6-phospho-D-gluconate hydro-lyase (2-dehydro-3-deoxy-6-phospho-D-gluconate-forming)" EXACT [EC:4.2.1.12]
synonym: "6-phospho-D-gluconate hydro-lyase activity" EXACT [EC:4.2.1.12]
synonym: "6-phosphogluconate dehydrase activity" EXACT [EC:4.2.1.12]
synonym: "6-phosphogluconate dehydratase activity" EXACT [EC:4.2.1.12]
synonym: "6-phosphogluconic dehydrase activity" EXACT [EC:4.2.1.12]
synonym: "gluconate 6-phosphate dehydratase activity" EXACT [EC:4.2.1.12]
synonym: "gluconate-6-phosphate dehydratase activity" EXACT [EC:4.2.1.12]
xref: EC:4.2.1.12
xref: KEGG:R02036
xref: MetaCyc:PGLUCONDEHYDRAT-RXN
xref: RHEA:17280
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0004457
name: lactate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: lactate + NAD+ = H+ + NADH + pyruvate." [GOC:ai, GOC:bf]
subset: gosubset_prok
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0004458
name: D-lactate dehydrogenase (cytochrome) activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c." [EC:1.1.2.4]
subset: gosubset_prok
synonym: "(R)-lactate:ferricytochrome-c 2-oxidoreductase activity" EXACT [EC:1.1.2.4]
synonym: "cytochrome-dependent D-(-)-lactate dehydrogenase activity" EXACT [EC:1.1.2.4]
synonym: "D-(-)-lactic cytochrome c reductase activity" EXACT [EC:1.1.2.4]
synonym: "D-lactate (cytochrome) dehydrogenase activity" EXACT [EC:1.1.2.4]
synonym: "D-lactate ferricytochrome c oxidoreductase activity" EXACT [EC:1.1.2.4]
synonym: "D-lactate-cytochrome c reductase activity" EXACT [EC:1.1.2.4]
synonym: "lactic acid dehydrogenase activity" BROAD [EC:1.1.2.4]
xref: EC:1.1.2.4
xref: MetaCyc:D-LACTATE-DEHYDROGENASE-CYTOCHROME-RXN
is_a: GO:0004457 ! lactate dehydrogenase activity
is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor

[Term]
id: GO:0004459
name: L-lactate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+." [EC:1.1.1.27, RHEA:23447]
subset: gosubset_prok
synonym: "L-lactic acid dehydrogenase activity" EXACT [EC:1.1.1.27]
synonym: "L-lactic dehydrogenase activity" EXACT [EC:1.1.1.27]
xref: EC:1.1.1.27
xref: MetaCyc:L-LACTATE-DEHYDROGENASE-RXN
xref: Reactome:REACT_100002 "(S)-Lactate + NAD+ <=> Pyruvate + NADH + H+, Bos taurus"
xref: Reactome:REACT_1010 "(S)-Lactate + NAD+ <=> Pyruvate + NADH + H+, Homo sapiens"
xref: Reactome:REACT_101688 "Pyruvate + NADH + H+ <=> (S)-Lactate + NAD+, Schizosaccharomyces pombe"
xref: Reactome:REACT_106663 "(S)-Lactate + NAD+ <=> Pyruvate + NADH + H+, Rattus norvegicus"
xref: Reactome:REACT_108879 "Pyruvate + NADH + H+ <=> (S)-Lactate + NAD+, Bos taurus"
xref: Reactome:REACT_109914 "Pyruvate + NADH + H+ <=> (S)-Lactate + NAD+, Staphylococcus aureus N315"
xref: Reactome:REACT_110161 "(S)-Lactate + NAD+ <=> Pyruvate + NADH + H+, Gallus gallus"
xref: Reactome:REACT_112284 "Pyruvate + NADH + H+ <=> (S)-Lactate + NAD+, Drosophila melanogaster"
xref: Reactome:REACT_112343 "(S)-Lactate + NAD+ <=> Pyruvate + NADH + H+, Drosophila melanogaster"
xref: Reactome:REACT_112780 "(S)-Lactate + NAD+ <=> Pyruvate + NADH + H+, Arabidopsis thaliana"
xref: Reactome:REACT_112887 "Pyruvate + NADH + H+ <=> (S)-Lactate + NAD+, Arabidopsis thaliana"
xref: Reactome:REACT_113309 "(S)-Lactate + NAD+ <=> Pyruvate + NADH + H+, Oryza sativa"
xref: Reactome:REACT_113500 "Pyruvate + NADH + H+ <=> (S)-Lactate + NAD+, Oryza sativa"
xref: Reactome:REACT_115097 "(S)-Lactate + NAD+ <=> Pyruvate + NADH + H+, Caenorhabditis elegans"
xref: Reactome:REACT_115372 "Pyruvate + NADH + H+ <=> (S)-Lactate + NAD+, Caenorhabditis elegans"
xref: Reactome:REACT_115608 "lactate + NAD+ <=> pyruvate + NADH + H+, Gallus gallus"
xref: Reactome:REACT_116117 "pyruvate + NADH + H+ <=> lactate + NAD+, Gallus gallus"
xref: Reactome:REACT_178 "Pyruvate + NADH + H+ <=> (S)-Lactate + NAD+, Homo sapiens"
xref: Reactome:REACT_29902 "(S)-Lactate + NAD+ <=> Pyruvate + NADH + H+, Xenopus tropicalis"
xref: Reactome:REACT_31172 "(S)-Lactate + NAD+ <=> Pyruvate + NADH + H+, Taeniopygia guttata"
xref: Reactome:REACT_31282 "Pyruvate + NADH + H+ <=> (S)-Lactate + NAD+, Gallus gallus"
xref: Reactome:REACT_77513 "Pyruvate + NADH + H+ <=> (S)-Lactate + NAD+, Taeniopygia guttata"
xref: Reactome:REACT_78115 "Pyruvate + NADH + H+ <=> (S)-Lactate + NAD+, Xenopus tropicalis"
xref: Reactome:REACT_80242 "(S)-Lactate + NAD+ <=> Pyruvate + NADH + H+, Schizosaccharomyces pombe"
xref: Reactome:REACT_81403 "(S)-Lactate + NAD+ <=> Pyruvate + NADH + H+, Danio rerio"
xref: Reactome:REACT_81615 "Pyruvate + NADH + H+ <=> (S)-Lactate + NAD+, Rattus norvegicus"
xref: Reactome:REACT_84410 "Pyruvate + NADH + H+ <=> (S)-Lactate + NAD+, Danio rerio"
xref: Reactome:REACT_85236 "Pyruvate + NADH + H+ <=> (S)-Lactate + NAD+, Mus musculus"
xref: Reactome:REACT_87441 "(S)-Lactate + NAD+ <=> Pyruvate + NADH + H+, Canis familiaris"
xref: Reactome:REACT_88565 "Pyruvate + NADH + H+ <=> (S)-Lactate + NAD+, Sus scrofa"
xref: Reactome:REACT_92252 "Pyruvate + NADH + H+ <=> (S)-Lactate + NAD+, Canis familiaris"
xref: Reactome:REACT_93008 "(S)-Lactate + NAD+ <=> Pyruvate + NADH + H+, Mus musculus"
xref: Reactome:REACT_95105 "(S)-Lactate + NAD+ <=> Pyruvate + NADH + H+, Sus scrofa"
xref: Reactome:REACT_97518 "(S)-Lactate + NAD+ <=> Pyruvate + NADH + H+, Staphylococcus aureus N315"
xref: RHEA:23447
is_a: GO:0004457 ! lactate dehydrogenase activity
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004460
name: L-lactate dehydrogenase (cytochrome) activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c." [EC:1.1.2.3]
subset: gosubset_prok
synonym: "(S)-lactate:ferricytochrome-c 2-oxidoreductase activity" EXACT [EC:1.1.2.3]
synonym: "cytochrome b2" RELATED []
synonym: "cytochrome b2 (flavin-free derivative of flavocytochrome b2)" RELATED [EC:1.1.2.3]
synonym: "dehydrogenase, lactate (cytochrome)" EXACT [EC:1.1.2.3]
synonym: "flavocytochrome b2" RELATED [EC:1.1.2.3]
synonym: "L(+)-lactate:cytochrome c oxidoreductase activity" EXACT [EC:1.1.2.3]
synonym: "L-lactate cytochrome c oxidoreductase activity" EXACT [EC:1.1.2.3]
synonym: "L-lactate cytochrome c reductase activity" EXACT [EC:1.1.2.3]
synonym: "L-lactate ferricytochrome c oxidoreductase activity" EXACT [EC:1.1.2.3]
synonym: "lactate dehydrogenase (cytochrome)" EXACT [EC:1.1.2.3]
synonym: "lactic acid dehydrogenase activity" BROAD [EC:1.1.2.3]
synonym: "lactic cytochrome c reductase activity" EXACT [EC:1.1.2.3]
xref: EC:1.1.2.3
xref: MetaCyc:L-LACTATE-DEHYDROGENASE-CYTOCHROME-RXN
is_a: GO:0004457 ! lactate dehydrogenase activity
is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor

[Term]
id: GO:0004461
name: lactose synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-galactose + D-glucose = UDP + lactose." [EC:2.4.1.22]
synonym: "lactose synthetase activity" EXACT [EC:2.4.1.22]
synonym: "UDP-galactose-glucose galactosyltransferase activity" EXACT [EC:2.4.1.22]
synonym: "UDP-galactose:D-glucose 4-beta-D-galactotransferase activity" EXACT [EC:2.4.1.22]
synonym: "UDPgalactose-glucose galactosyltransferase activity" EXACT [EC:2.4.1.22]
synonym: "UDPgalactose:D-glucose 4-beta-D-galactotransferase activity" EXACT [EC:2.4.1.22]
synonym: "uridine diphosphogalactose-glucose galactosyltransferase activity" EXACT [EC:2.4.1.22]
xref: EC:2.4.1.22
xref: MetaCyc:LACTOSE-SYNTHASE-RXN
xref: RHEA:12407
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0004462
name: lactoylglutathione lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal." [EC:4.4.1.5, RHEA:19072]
subset: gosubset_prok
synonym: "(R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing) activity" EXACT [EC:4.4.1.5]
synonym: "(R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing; glutathione-forming)" EXACT [EC:4.4.1.5]
synonym: "aldoketomutase activity" EXACT [EC:4.4.1.5]
synonym: "glyoxalase I activity" EXACT [EC:4.4.1.5]
synonym: "glyoxylase I" RELATED [EC:4.4.1.5]
synonym: "ketone-aldehyde mutase activity" EXACT [EC:4.4.1.5]
synonym: "methylglyoxalase activity" EXACT [EC:4.4.1.5]
xref: EC:4.4.1.5
xref: KEGG:R02530
xref: MetaCyc:GLYOXI-RXN
xref: RHEA:19072
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0004463
name: leukotriene-A4 hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + leukotriene A(4) = leukotriene B(4)." [EC:3.3.2.6, RHEA:22327]
subset: gosubset_prok
synonym: "(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate hydrolase activity" EXACT [EC:3.3.2.6]
synonym: "leukotriene A(4) hydrolase activity" EXACT [EC:3.3.2.6]
synonym: "leukotriene A4 hydrolase activity" EXACT [EC:3.3.2.6]
synonym: "LTA-4 hydrolase activity" EXACT [EC:3.3.2.6]
synonym: "LTA4 hydrolase activity" EXACT [EC:3.3.2.6]
synonym: "LTA4H" RELATED [EC:3.3.2.6]
xref: EC:3.3.2.6
xref: KEGG:R03057
xref: MetaCyc:LEUKOTRIENE-A4-HYDROLASE-RXN
xref: Reactome:REACT_107223 "LTA4 is hydrolyzed to LTB4, Mus musculus"
xref: Reactome:REACT_113583 "LTA4 is hydrolyzed to LTB4, Dictyostelium discoideum"
xref: Reactome:REACT_113737 "LTA4 is hydrolyzed to LTB4, Mycobacterium tuberculosis"
xref: Reactome:REACT_115125 "LTA4 is hydrolyzed to LTB4, Saccharomyces cerevisiae"
xref: Reactome:REACT_115164 "LTA4 is hydrolyzed to LTB4, Schizosaccharomyces pombe"
xref: Reactome:REACT_15478 "LTA4 is hydrolyzed to LTB4, Homo sapiens"
xref: Reactome:REACT_28633 "LTA4 is hydrolyzed to LTB4, Drosophila melanogaster"
xref: Reactome:REACT_80031 "LTA4 is hydrolyzed to LTB4, Canis familiaris"
xref: Reactome:REACT_82629 "LTA4 is hydrolyzed to LTB4, Caenorhabditis elegans"
xref: Reactome:REACT_83037 "LTA4 is hydrolyzed to LTB4, Rattus norvegicus"
xref: Reactome:REACT_87303 "LTA4 is hydrolyzed to LTB4, Xenopus tropicalis"
xref: Reactome:REACT_91502 "LTA4 is hydrolyzed to LTB4, Bos taurus"
xref: Reactome:REACT_92157 "LTA4 is hydrolyzed to LTB4, Taeniopygia guttata"
xref: Reactome:REACT_93154 "LTA4 is hydrolyzed to LTB4, Danio rerio"
xref: Reactome:REACT_94702 "LTA4 is hydrolyzed to LTB4, Gallus gallus"
xref: Reactome:REACT_98948 "LTA4 is hydrolyzed to LTB4, Sus scrofa"
xref: RHEA:22327
is_a: GO:0016803 ! ether hydrolase activity

[Term]
id: GO:0004464
name: leukotriene-C4 synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: leukotriene C(4) = glutathione + leukotriene A(4)." [EC:4.4.1.20, RHEA:17620]
comment: Note that this function was EC:2.5.1.37.
synonym: "(7E,9E,11Z,14Z)-(5S,6R)-5,6-epoxyicosa-7,9,11,14-tetraenoate:glutathione leukotriene-transferase (epoxide-ring-opening)" EXACT [EC:4.4.1.20]
synonym: "(7E,9E,11Z,14Z)-(5S,6R)-6-(glutathion-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate glutathione-lyase (epoxide-forming)" EXACT [EC:4.4.1.20]
synonym: "leukotriene A(4):glutathione S-leukotrienyltransferase activity" EXACT [EC:4.4.1.20]
synonym: "leukotriene A4:glutathione S-leukotrienyltransferase activity" EXACT [EC:4.4.1.20]
synonym: "leukotriene C(4) synthetase activity" EXACT [EC:4.4.1.20]
synonym: "leukotriene C4 synthetase activity" EXACT [EC:4.4.1.20]
synonym: "leukotriene-C4 glutathione-lyase (leukotriene-A4-forming)" EXACT [EC:4.4.1.20]
synonym: "LTC(4) synthase activity" EXACT [EC:4.4.1.20]
synonym: "LTC(4) synthetase activity" EXACT [EC:4.4.1.20]
synonym: "LTC4 synthase activity" EXACT [EC:4.4.1.20]
synonym: "LTC4 synthetase activity" EXACT [EC:4.4.1.20]
xref: EC:4.4.1.20
xref: KEGG:R03059
xref: MetaCyc:LEUKOTRIENE-C4-SYNTHASE-RXN
xref: Reactome:REACT_104142 "LTA4 conjugates with glutathione to form LTC4, Danio rerio"
xref: Reactome:REACT_108117 "LTA4 conjugates with glutathione to form LTC4, Canis familiaris"
xref: Reactome:REACT_110444 "LTA4 conjugates with glutathione to form LTC4, Xenopus tropicalis"
xref: Reactome:REACT_15413 "LTA4 conjugates with glutathione to form LTC4, Homo sapiens"
xref: Reactome:REACT_29500 "LTA4 conjugates with glutathione to form LTC4, Gallus gallus"
xref: Reactome:REACT_82111 "LTA4 conjugates with glutathione to form LTC4, Mus musculus"
xref: Reactome:REACT_84699 "LTA4 conjugates with glutathione to form LTC4, Rattus norvegicus"
xref: Reactome:REACT_88206 "LTA4 conjugates with glutathione to form LTC4, Bos taurus"
xref: Reactome:REACT_95364 "LTA4 conjugates with glutathione to form LTC4, Sus scrofa"
xref: Reactome:REACT_95633 "LTA4 conjugates with glutathione to form LTC4, Taeniopygia guttata"
xref: RHEA:17620
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0004465
name: lipoprotein lipase activity
namespace: molecular_function
def: "Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate, where the triacylglycerol is part of a lipoprotein." [EC:3.1.1.34, GOC:bf]
synonym: "clearing factor lipase activity" RELATED [EC:3.1.1.34]
synonym: "diacylglycerol hydrolase activity" EXACT [EC:3.1.1.34]
synonym: "diacylglycerol lipase activity" EXACT [EC:3.1.1.34]
synonym: "diglyceride lipase activity" EXACT [EC:3.1.1.34]
synonym: "lipemia-clearing factor" RELATED [EC:3.1.1.34]
synonym: "postheparin esterase activity" EXACT [EC:3.1.1.34]
synonym: "postheparin lipase activity" EXACT [EC:3.1.1.34]
synonym: "triacylglycero-protein acylhydrolase activity" EXACT [EC:3.1.1.34]
xref: EC:3.1.1.34
xref: MetaCyc:LIPOPROTEIN-LIPASE-RXN
xref: Reactome:REACT_103845 "chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols, Canis familiaris"
xref: Reactome:REACT_104919 "chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols, Mus musculus"
xref: Reactome:REACT_33675 "chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols, Sus scrofa"
xref: Reactome:REACT_6734 "chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols, Homo sapiens"
xref: Reactome:REACT_81730 "chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols, Bos taurus"
is_a: GO:0004806 ! triglyceride lipase activity

[Term]
id: GO:0004466
name: long-chain-acyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + ETF = 2,3-dehydroacyl-CoA + reduced ETF." [EC:1.3.99.13]
subset: gosubset_prok
synonym: "long-chain acyl-coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.13]
synonym: "long-chain-acyl-CoA:(acceptor) 2,3-oxidoreductase activity" EXACT [EC:1.3.99.13]
synonym: "long-chain-acyl-CoA:acceptor 2,3-oxidoreductase activity" EXACT [EC:1.3.99.13]
synonym: "palmitoyl-CoA dehydrogenase activity" EXACT [EC:1.3.99.13]
synonym: "palmitoyl-coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.13]
xref: EC:1.3.99.13
xref: MetaCyc:LONG-CHAIN-ACYL-COA-DEHYDROGENASE-RXN
is_a: GO:0003995 ! acyl-CoA dehydrogenase activity

[Term]
id: GO:0004467
name: long-chain fatty acid-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [CHEBI:15904, EC:6.2.1.3]
subset: gosubset_prok
synonym: "ACS3" NARROW [EC:6.2.1.3]
synonym: "acyl-activating enzyme activity" BROAD [EC:6.2.1.3]
synonym: "acyl-CoA synthetase activity" EXACT [EC:6.2.1.3]
synonym: "arachidonyl-CoA synthetase" NARROW [EC:6.2.1.3]
synonym: "FAA1" NARROW [EC:6.2.1.3]
synonym: "fatty acid thiokinase (long chain) activity" EXACT [EC:6.2.1.3]
synonym: "fatty acid thiokinase (long-chain) activity" EXACT [EC:6.2.1.3]
synonym: "LCFA synthetase activity" EXACT [EC:6.2.1.3]
synonym: "lignoceroyl-CoA synthase activity" EXACT [EC:6.2.1.3]
synonym: "long chain fatty acyl-CoA synthetase activity" EXACT [EC:6.2.1.3]
synonym: "long-chain acyl CoA synthetase activity" EXACT [EC:6.2.1.3]
synonym: "long-chain acyl-CoA synthetase activity" EXACT []
synonym: "long-chain acyl-CoA synthetase I" NARROW [EC:6.2.1.3]
synonym: "long-chain acyl-CoA synthetase II" NARROW [EC:6.2.1.3]
synonym: "long-chain acyl-coenzyme A synthetase activity" EXACT [EC:6.2.1.3]
synonym: "long-chain fatty acid activation" RELATED []
synonym: "long-chain fatty acyl coenzyme A synthetase activity" EXACT [EC:6.2.1.3]
synonym: "long-chain-fatty-acid-CoA ligase activity" EXACT []
synonym: "long-chain-fatty-acyl-CoA synthetase activity" EXACT []
synonym: "oleoyl-CoA synthetase" NARROW [EC:6.2.1.3]
synonym: "palmitoyl coenzyme A synthetase" NARROW [EC:6.2.1.3]
synonym: "palmitoyl-CoA ligase" NARROW [EC:6.2.1.3]
synonym: "palmitoyl-CoA synthase" NARROW [EC:6.2.1.3]
synonym: "pristanoyl-CoA synthetase" NARROW [EC:6.2.1.3]
synonym: "stearoyl-CoA synthetase" NARROW [EC:6.2.1.3]
synonym: "thiokinase" RELATED [EC:6.2.1.3]
xref: EC:6.2.1.3
xref: MetaCyc:ACYLCOASYN-RXN
xref: MetaCyc:PWY-5143
xref: Reactome:REACT_10000 "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS), Homo sapiens"
xref: Reactome:REACT_100146 "THCA is conjugated with Coenzyme A (SLC27A5 BACS), Danio rerio"
xref: Reactome:REACT_10020 "THCA is conjugated with Coenzyme A (SLC27A5 BACS), Homo sapiens"
xref: Reactome:REACT_10034 "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS), Homo sapiens"
xref: Reactome:REACT_100377 "THCA is conjugated with Coenzyme A (SLC27A5 BACS), Bos taurus"
xref: Reactome:REACT_10049 "THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Homo sapiens"
xref: Reactome:REACT_10064 "DHCA is conjugated with Coenzyme A (SLC27A5 BACS), Homo sapiens"
xref: Reactome:REACT_10087 "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS), Homo sapiens"
xref: Reactome:REACT_10106 "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Homo sapiens"
xref: Reactome:REACT_10119 "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Homo sapiens"
xref: Reactome:REACT_101550 "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS), Gallus gallus"
xref: Reactome:REACT_102048 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL5], Bos taurus"
xref: Reactome:REACT_102674 "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Danio rerio"
xref: Reactome:REACT_102719 "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS), Taeniopygia guttata"
xref: Reactome:REACT_102779 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Gallus gallus"
xref: Reactome:REACT_103147 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL1], Canis familiaris"
xref: Reactome:REACT_103154 "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Canis familiaris"
xref: Reactome:REACT_103348 "DHCA is conjugated with Coenzyme A (SLC27A5 BACS), Rattus norvegicus"
xref: Reactome:REACT_104228 "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS), Mus musculus"
xref: Reactome:REACT_104748 "THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Xenopus tropicalis"
xref: Reactome:REACT_105072 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL5], Taeniopygia guttata"
xref: Reactome:REACT_105167 "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS), Rattus norvegicus"
xref: Reactome:REACT_105842 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL5], Gallus gallus"
xref: Reactome:REACT_106315 "DHCA is conjugated with Coenzyme A (SLC27A5 BACS), Taeniopygia guttata"
xref: Reactome:REACT_106400 "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Xenopus tropicalis"
xref: Reactome:REACT_106582 "THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Bos taurus"
xref: Reactome:REACT_107010 "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Bos taurus"
xref: Reactome:REACT_107065 "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Mus musculus"
xref: Reactome:REACT_107825 "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS), Gallus gallus"
xref: Reactome:REACT_108040 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Drosophila melanogaster"
xref: Reactome:REACT_108152 "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Mus musculus"
xref: Reactome:REACT_108327 "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Bos taurus"
xref: Reactome:REACT_108413 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Arabidopsis thaliana"
xref: Reactome:REACT_109181 "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS), Rattus norvegicus"
xref: Reactome:REACT_109281 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Oryza sativa"
xref: Reactome:REACT_109377 "DHCA is conjugated with Coenzyme A (SLC27A5 BACS), Canis familiaris"
xref: Reactome:REACT_109580 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Taeniopygia guttata"
xref: Reactome:REACT_110284 "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS), Taeniopygia guttata"
xref: Reactome:REACT_110400 "THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Mycobacterium tuberculosis"
xref: Reactome:REACT_110600 "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS), Bos taurus"
xref: Reactome:REACT_110635 "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Bos taurus"
xref: Reactome:REACT_11137 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL1], Homo sapiens"
xref: Reactome:REACT_112002 "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS), Saccharomyces cerevisiae"
xref: Reactome:REACT_112185 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Dictyostelium discoideum"
xref: Reactome:REACT_112197 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Mycobacterium tuberculosis"
xref: Reactome:REACT_112234 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL5], Dictyostelium discoideum"
xref: Reactome:REACT_112314 "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Taeniopygia guttata"
xref: Reactome:REACT_112696 "THCA is conjugated with Coenzyme A (SLC27A5 BACS), Saccharomyces cerevisiae"
xref: Reactome:REACT_113165 "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Saccharomyces cerevisiae"
xref: Reactome:REACT_113283 "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Saccharomyces cerevisiae"
xref: Reactome:REACT_113402 "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Taeniopygia guttata"
xref: Reactome:REACT_113433 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Plasmodium falciparum"
xref: Reactome:REACT_113477 "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS), Saccharomyces cerevisiae"
xref: Reactome:REACT_113562 "DHCA is conjugated with Coenzyme A (SLC27A5 BACS), Saccharomyces cerevisiae"
xref: Reactome:REACT_113604 "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Taeniopygia guttata"
xref: Reactome:REACT_114408 "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Saccharomyces cerevisiae"
xref: Reactome:REACT_114641 "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS), Saccharomyces cerevisiae"
xref: Reactome:REACT_114941 "THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Saccharomyces cerevisiae"
xref: Reactome:REACT_115449 "THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Taeniopygia guttata"
xref: Reactome:REACT_115464 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Xenopus tropicalis"
xref: Reactome:REACT_22247 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL6], Homo sapiens"
xref: Reactome:REACT_22376 "arachidonate + CoASH + ATP => arachidonoyl-CoA + AMP + pyrophosphate + H2O [ACSL4], Homo sapiens"
xref: Reactome:REACT_22410 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL5], Homo sapiens"
xref: Reactome:REACT_28244 "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Danio rerio"
xref: Reactome:REACT_28477 "THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Rattus norvegicus"
xref: Reactome:REACT_28700 "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Rattus norvegicus"
xref: Reactome:REACT_29173 "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS), Canis familiaris"
xref: Reactome:REACT_30197 "THCA is conjugated with Coenzyme A (SLC27A5 BACS), Canis familiaris"
xref: Reactome:REACT_30265 "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Mycobacterium tuberculosis"
xref: Reactome:REACT_32832 "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Mycobacterium tuberculosis"
xref: Reactome:REACT_33155 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Sus scrofa"
xref: Reactome:REACT_33243 "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS), Mus musculus"
xref: Reactome:REACT_34606 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL5], Xenopus tropicalis"
xref: Reactome:REACT_34728 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL1], Gallus gallus"
xref: Reactome:REACT_77878 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL5], Mus musculus"
xref: Reactome:REACT_78613 "THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Danio rerio"
xref: Reactome:REACT_79153 "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS), Danio rerio"
xref: Reactome:REACT_79206 "THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Mus musculus"
xref: Reactome:REACT_79554 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL1], Danio rerio"
xref: Reactome:REACT_79937 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL1], Bos taurus"
xref: Reactome:REACT_80135 "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Canis familiaris"
xref: Reactome:REACT_80410 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL5], Sus scrofa"
xref: Reactome:REACT_80584 "DHCA is conjugated with Coenzyme A (SLC27A5 BACS), Mus musculus"
xref: Reactome:REACT_82148 "DHCA is conjugated with Coenzyme A (SLC27A5 BACS), Bos taurus"
xref: Reactome:REACT_82230 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Saccharomyces cerevisiae"
xref: Reactome:REACT_82547 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL1], Xenopus tropicalis"
xref: Reactome:REACT_83689 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL1], Rattus norvegicus"
xref: Reactome:REACT_83959 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL5], Caenorhabditis elegans"
xref: Reactome:REACT_84131 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Canis familiaris"
xref: Reactome:REACT_84943 "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Rattus norvegicus"
xref: Reactome:REACT_85114 "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS), Rattus norvegicus"
xref: Reactome:REACT_85507 "THCA is conjugated with Coenzyme A (SLC27A5 BACS), Rattus norvegicus"
xref: Reactome:REACT_86419 "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS), Canis familiaris"
xref: Reactome:REACT_86526 "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS), Mycobacterium tuberculosis"
xref: Reactome:REACT_86586 "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS), Mycobacterium tuberculosis"
xref: Reactome:REACT_86823 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL1], Taeniopygia guttata"
xref: Reactome:REACT_86910 "THCA is conjugated with Coenzyme A (SLC27A5 BACS), Mycobacterium tuberculosis"
xref: Reactome:REACT_87364 "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS), Bos taurus"
xref: Reactome:REACT_87672 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Schizosaccharomyces pombe"
xref: Reactome:REACT_87771 "THCA is conjugated with Coenzyme A (SLC27A5 BACS), Gallus gallus"
xref: Reactome:REACT_88190 "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS), Danio rerio"
xref: Reactome:REACT_88276 "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS), Bos taurus"
xref: Reactome:REACT_88286 "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Sus scrofa"
xref: Reactome:REACT_88806 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL5], Danio rerio"
xref: Reactome:REACT_89212 "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Rattus norvegicus"
xref: Reactome:REACT_89373 "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Mus musculus"
xref: Reactome:REACT_89406 "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS), Mus musculus"
xref: Reactome:REACT_89639 "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Mycobacterium tuberculosis"
xref: Reactome:REACT_89817 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Rattus norvegicus"
xref: Reactome:REACT_89907 "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS), Taeniopygia guttata"
xref: Reactome:REACT_89914 "THCA is conjugated with Coenzyme A (SLC27A5 BACS), Taeniopygia guttata"
xref: Reactome:REACT_90120 "DHCA is conjugated with Coenzyme A (SLC27A5 BACS), Mycobacterium tuberculosis"
xref: Reactome:REACT_90313 "THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Sus scrofa"
xref: Reactome:REACT_91245 "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Canis familiaris"
xref: Reactome:REACT_91297 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Mus musculus"
xref: Reactome:REACT_91342 "THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Canis familiaris"
xref: Reactome:REACT_91481 "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS), Gallus gallus"
xref: Reactome:REACT_92094 "THCA is conjugated with Coenzyme A (SLC27A5 BACS), Mus musculus"
xref: Reactome:REACT_92380 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Caenorhabditis elegans"
xref: Reactome:REACT_930 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Homo sapiens"
xref: Reactome:REACT_94093 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL1], Mus musculus"
xref: Reactome:REACT_94281 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL5], Rattus norvegicus"
xref: Reactome:REACT_95456 "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS), Mycobacterium tuberculosis"
xref: Reactome:REACT_96062 "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Sus scrofa"
xref: Reactome:REACT_96718 "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Xenopus tropicalis"
xref: Reactome:REACT_97075 "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Sus scrofa"
xref: Reactome:REACT_97472 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL5], Canis familiaris"
xref: Reactome:REACT_97742 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL1], Sus scrofa"
xref: Reactome:REACT_97937 "DHCA is conjugated with Coenzyme A (SLC27A5 BACS), Gallus gallus"
xref: Reactome:REACT_98426 "DHCA is conjugated with Coenzyme A (SLC27A5 BACS), Danio rerio"
xref: Reactome:REACT_98486 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Bos taurus"
xref: Reactome:REACT_98598 "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS), Danio rerio"
xref: Reactome:REACT_98628 "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Danio rerio"
xref: Reactome:REACT_98739 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Danio rerio"
xref: Reactome:REACT_98845 "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Xenopus tropicalis"
xref: Reactome:REACT_99260 "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS), Canis familiaris"
xref: Reactome:REACT_9970 "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Homo sapiens"
xref: UM-BBD_enzymeID:e0025
is_a: GO:0015645 ! fatty acid ligase activity
relationship: part_of GO:0001676 ! long-chain fatty acid metabolic process

[Term]
id: GO:0004468
name: lysine N-acetyltransferase activity, acting on acetyl phosphate as donor
namespace: molecular_function
def: "Catalysis of the reaction: acetyl phosphate + L-lysine = phosphate + N6-acetyl-L-lysine." [EC:2.3.1.32]
subset: gosubset_prok
synonym: "acetyl-phosphate:L-lysine 6-N-acetyltransferase activity" EXACT [EC:2.3.1.32]
synonym: "acetyl-phosphate:L-lysine N6-acetyltransferase activity" EXACT [EC:2.3.1.32]
synonym: "LAT activity" EXACT [EC:2.3.1.32]
synonym: "lysine acetyltransferase activity" EXACT []
synonym: "lysine N(6)-acetyltransferase activity" EXACT [EC:2.3.1.32]
synonym: "lysine N6-acetyltransferase activity" EXACT [EC:2.3.1.32]
xref: EC:2.3.1.32
xref: MetaCyc:LYSINE-N-ACETYLTRANSFERASE-RXN
xref: RHEA:14420
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0004470
name: malic enzyme activity
namespace: molecular_function
def: "Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate." [ISBN:0198506732]
subset: gosubset_prok
synonym: "pyruvic-malic carboxylase activity" EXACT [EC:1.1.1.39]
is_a: GO:0016615 ! malate dehydrogenase activity

[Term]
id: GO:0004471
name: malate dehydrogenase (decarboxylating) (NAD+) activity
namespace: molecular_function
alt_id: GO:0004472
alt_id: GO:0016619
def: "Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+." [EC:1.1.1.38, EC:1.1.1.39]
comment: For decarboxylation of oxaloacetate (the second substrate listed in EC:1.1.1.38), see 'oxaloacetate decarboxylase activity ; GO:0008948'.
subset: gosubset_prok
synonym: "'malic' enzyme" RELATED [EC:1.1.1.38, EC:1.1.1.39]
synonym: "(S)-malate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.39]
synonym: "(S)-malate:NAD+ oxidoreductase (oxaloacetate-decarboxylating)" EXACT [EC:1.1.1.38]
synonym: "malate dehydrogenase (decarboxylating) activity" EXACT [EC:1.1.1.39]
synonym: "malate dehydrogenase (oxaloacetate-decarboxylating) activity" EXACT []
synonym: "NAD-linked malic enzyme" RELATED [EC:1.1.1.38]
synonym: "NAD-malic enzyme activity" BROAD [EC:1.1.1.38, EC:1.1.1.39]
synonym: "NAD-specific malic enzyme" RELATED [EC:1.1.1.38, EC:1.1.1.39]
xref: EC:1.1.1.38
xref: EC:1.1.1.39
xref: KEGG:R00214
xref: MetaCyc:1.1.1.39-RXN
xref: MetaCyc:MALIC-NAD-RXN
xref: RHEA:12656
is_a: GO:0004470 ! malic enzyme activity
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004473
name: malate dehydrogenase (decarboxylating) (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+." [EC:1.1.1.40]
comment: For decarboxylation of oxaloacetate (the second substrate listed in EC:1.1.1.40), see 'oxaloacetate decarboxylase activity ; GO:0008948'.
subset: gosubset_prok
synonym: "'malic' enzyme" RELATED [EC:1.1.1.40]
synonym: "(S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" EXACT [EC:1.1.1.40]
synonym: "L-malate:NADP oxidoreductase activity" EXACT [EC:1.1.1.40]
synonym: "malate dehydrogenase (decarboxylating, NADP)" EXACT [EC:1.1.1.40]
synonym: "malate dehydrogenase (NADP, decarboxylating)" EXACT [EC:1.1.1.40]
synonym: "NADP-linked decarboxylating malic enzyme" RELATED [EC:1.1.1.40]
synonym: "NADP-malic enzyme activity" EXACT [EC:1.1.1.40]
synonym: "NADP-specific malate dehydrogenase activity" EXACT [EC:1.1.1.40]
synonym: "NADP-specific malic enzyme" RELATED [EC:1.1.1.40]
xref: EC:1.1.1.40
xref: KEGG:R00216
xref: MetaCyc:MALIC-NADP-RXN
xref: RHEA:18256
is_a: GO:0004470 ! malic enzyme activity
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004474
name: malate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + glyoxylate + H(2)O = (S)-malate + CoA + H(+)." [EC:2.3.3.9, RHEA:18184]
comment: Note that this function was formerly EC:4.1.3.2.
subset: gosubset_prok
synonym: "acetyl-CoA:glyoxylate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)" EXACT [EC:2.3.3.9]
synonym: "glyoxylate transacetase activity" EXACT [EC:2.3.3.9]
synonym: "glyoxylate transacetylase activity" EXACT [EC:2.3.3.9]
synonym: "glyoxylic transacetase activity" EXACT [EC:2.3.3.9]
synonym: "L-malate glyoxylate-lyase (CoA-acetylating) activity" EXACT [EC:2.3.3.9]
synonym: "malate condensing enzyme activity" RELATED [EC:2.3.3.9]
synonym: "malate synthetase activity" EXACT [EC:2.3.3.9]
synonym: "malic synthetase activity" EXACT [EC:2.3.3.9]
synonym: "malic-condensing enzyme activity" RELATED [EC:2.3.3.9]
xref: EC:2.3.3.9
xref: KEGG:R00472
xref: MetaCyc:MALSYN-RXN
xref: RHEA:18184
is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

[Term]
id: GO:0004475
name: mannose-1-phosphate guanylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-mannose 1-phosphate + GTP = diphosphate + GDP-alpha-D-mannose." [EC:2.7.7.13, RHEA:15232]
subset: gosubset_prok
synonym: "GDP-mannose pyrophosphorylase activity" RELATED [EC:2.7.7.13]
synonym: "GTP-mannose-1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.13]
synonym: "GTP:alpha-D-mannose-1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.13]
synonym: "GTP:mannose-1-phosphate guanylyltransferase activity" EXACT []
synonym: "guanosine 5'-diphospho-D-mannose pyrophosphorylase activity" EXACT [EC:2.7.7.13]
synonym: "guanosine diphosphomannose pyrophosphorylase activity" EXACT [EC:2.7.7.13]
synonym: "guanosine triphosphate-mannose 1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.13]
synonym: "mannose 1-phosphate guanylyltransferase (guanosine triphosphate)" EXACT [EC:2.7.7.13]
synonym: "PIM-GMP (phosphomannose isomerase-guanosine 5'-diphospho-D-mannose pyrophosphorylase)" RELATED [EC:2.7.7.13]
xref: EC:2.7.7.13
xref: KEGG:R00885
xref: MetaCyc:2.7.7.13-RXN
xref: Reactome:REACT_22254 "Mannose-1-phosphate converted to GDP-Mannose, Homo sapiens"
xref: Reactome:REACT_22422 "Mannose-1-phosphate converted to GDP-Mannose, Rattus norvegicus"
xref: RHEA:15232
is_a: GO:0008905 ! mannose-phosphate guanylyltransferase activity

[Term]
id: GO:0004476
name: mannose-6-phosphate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-mannose 6-phosphate = D-fructose 6-phosphate." [EC:5.3.1.8]
subset: gosubset_prok
synonym: "D-mannose-6-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.8]
synonym: "D-mannose-6-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.8]
synonym: "mannose phosphate isomerase activity" EXACT [EC:5.3.1.8]
synonym: "phosphohexoisomerase activity" BROAD [EC:5.3.1.8]
synonym: "phosphohexomutase activity" BROAD [EC:5.3.1.8]
synonym: "phosphomannoisomerase activity" EXACT [EC:5.3.1.8]
synonym: "phosphomannose isomerase activity" EXACT [EC:5.3.1.8]
xref: EC:5.3.1.8
xref: MetaCyc:MANNPISOM-RXN
xref: Reactome:REACT_22388 "Fructose 6-phosphate isomerizes to Mannose 6-phosphate, Homo sapiens"
xref: RHEA:12359
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0004477
name: methenyltetrahydrofolate cyclohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate." [EC:3.5.4.9]
subset: gosubset_prok
synonym: "5,10-methenyl-THF cyclohydrolase activity" EXACT [GOC:vw]
synonym: "5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing)" EXACT [EC:3.5.4.9]
synonym: "citrovorum factor cyclodehydrase activity" EXACT [EC:3.5.4.9]
synonym: "formyl-methenyl-methylenetetrahydrofolate synthetase (combined)" EXACT [EC:3.5.4.9]
xref: EC:3.5.4.9
xref: MetaCyc:METHENYLTHFCYCLOHYDRO-RXN
xref: Reactome:REACT_100157 "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate, Saccharomyces cerevisiae"
xref: Reactome:REACT_101585 "10-formylTHF polyglutamate <=> 5,10-methenylTHF polyglutamate + H2O, Bos taurus"
xref: Reactome:REACT_102491 "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate, Taeniopygia guttata"
xref: Reactome:REACT_103687 "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate, Gallus gallus"
xref: Reactome:REACT_106684 "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate, Canis familiaris"
xref: Reactome:REACT_108601 "10-formylTHF polyglutamate <=> 5,10-methenylTHF polyglutamate + H2O, Gallus gallus"
xref: Reactome:REACT_109212 "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate, Mus musculus"
xref: Reactome:REACT_110703 "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate, Danio rerio"
xref: Reactome:REACT_11074 "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate, Homo sapiens"
xref: Reactome:REACT_11205 "10-formylTHF polyglutamate <=> 5,10-methenylTHF polyglutamate + H2O, Homo sapiens"
xref: Reactome:REACT_112952 "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate, Xenopus tropicalis"
xref: Reactome:REACT_114540 "10-formylTHF polyglutamate <=> 5,10-methenylTHF polyglutamate + H2O, Xenopus tropicalis"
xref: Reactome:REACT_28240 "10-formylTHF polyglutamate <=> 5,10-methenylTHF polyglutamate + H2O, Mus musculus"
xref: Reactome:REACT_29637 "10-formylTHF polyglutamate <=> 5,10-methenylTHF polyglutamate + H2O, Canis familiaris"
xref: Reactome:REACT_31039 "10-formylTHF polyglutamate <=> 5,10-methenylTHF polyglutamate + H2O, Danio rerio"
xref: Reactome:REACT_32652 "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate, Schizosaccharomyces pombe"
xref: Reactome:REACT_33466 "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate, Bos taurus"
xref: Reactome:REACT_79321 "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate, Drosophila melanogaster"
xref: Reactome:REACT_80741 "10-formylTHF polyglutamate <=> 5,10-methenylTHF polyglutamate + H2O, Drosophila melanogaster"
xref: Reactome:REACT_82938 "10-formylTHF polyglutamate <=> 5,10-methenylTHF polyglutamate + H2O, Taeniopygia guttata"
xref: Reactome:REACT_83916 "10-formylTHF polyglutamate <=> 5,10-methenylTHF polyglutamate + H2O, Saccharomyces cerevisiae"
xref: Reactome:REACT_86028 "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate, Mycobacterium tuberculosis"
xref: Reactome:REACT_86775 "10-formylTHF polyglutamate <=> 5,10-methenylTHF polyglutamate + H2O, Schizosaccharomyces pombe"
xref: Reactome:REACT_89595 "10-formylTHF polyglutamate <=> 5,10-methenylTHF polyglutamate + H2O, Sus scrofa"
xref: Reactome:REACT_89688 "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate, Sus scrofa"
xref: Reactome:REACT_89911 "10-formylTHF polyglutamate <=> 5,10-methenylTHF polyglutamate + H2O, Rattus norvegicus"
xref: Reactome:REACT_91311 "10-formylTHF polyglutamate <=> 5,10-methenylTHF polyglutamate + H2O, Mycobacterium tuberculosis"
xref: Reactome:REACT_93910 "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate, Rattus norvegicus"
xref: RHEA:23703
is_a: GO:0019238 ! cyclohydrolase activity

[Term]
id: GO:0004478
name: methionine adenosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine." [EC:2.5.1.6]
subset: gosubset_prok
synonym: "adenosylmethionine synthetase activity" EXACT [EC:2.5.1.6]
synonym: "AdoMet synthetase activity" EXACT [EC:2.5.1.6]
synonym: "ATP-methionine adenosyltransferase activity" EXACT [EC:2.5.1.6]
synonym: "ATP:L-methionine S-adenosyltransferase activity" EXACT [EC:2.5.1.6]
synonym: "methionine S-adenosyltransferase activity" EXACT [EC:2.5.1.6]
synonym: "methionine-activating enzyme" RELATED [EC:2.5.1.6]
synonym: "S-adenosyl-L-methionine synthetase activity" EXACT [EC:2.5.1.6]
synonym: "S-adenosylmethionine synthase activity" EXACT [EC:2.5.1.6]
synonym: "S-adenosylmethionine synthetase activity" EXACT [EC:2.5.1.6]
xref: EC:2.5.1.6
xref: MetaCyc:S-ADENMETSYN-RXN
xref: Reactome:REACT_103144 "SAM is sythesized from methionine's reaction with ATP, Gallus gallus"
xref: Reactome:REACT_103329 "SAM is sythesized from methionine's reaction with ATP, Taeniopygia guttata"
xref: Reactome:REACT_105520 "SAM is sythesized from methionine's reaction with ATP, Rattus norvegicus"
xref: Reactome:REACT_115032 "SAM is sythesized from methionine's reaction with ATP, Staphylococcus aureus N315"
xref: Reactome:REACT_32402 "SAM is sythesized from methionine's reaction with ATP, Danio rerio"
xref: Reactome:REACT_60836 "SAM is sythesized from methionine's reaction with ATP, Bos taurus"
xref: Reactome:REACT_6819 "SAM is sythesized from methionine's reaction with ATP, Homo sapiens"
xref: Reactome:REACT_77762 "SAM is sythesized from methionine's reaction with ATP, Saccharomyces cerevisiae"
xref: Reactome:REACT_77766 "SAM is sythesized from methionine's reaction with ATP, Mycobacterium tuberculosis"
xref: Reactome:REACT_77967 "SAM is sythesized from methionine's reaction with ATP, Canis familiaris"
xref: Reactome:REACT_87465 "SAM is sythesized from methionine's reaction with ATP, Sus scrofa"
xref: Reactome:REACT_91839 "SAM is sythesized from methionine's reaction with ATP, Schizosaccharomyces pombe"
xref: Reactome:REACT_92413 "SAM is sythesized from methionine's reaction with ATP, Mus musculus"
xref: Reactome:REACT_96978 "SAM is sythesized from methionine's reaction with ATP, Xenopus tropicalis"
xref: RHEA:21083
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0004479
name: methionyl-tRNA formyltransferase activity
namespace: molecular_function
alt_id: GO:0001718
alt_id: GO:0070128
def: "Catalysis of the reaction: 10-formyltetrahydrofolate + L-methionyl-tRNA + H2O = tetrahydrofolate + N-formylmethionyl-tRNA." [EC:2.1.2.9]
subset: gosubset_prok
synonym: "10-formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase activity" EXACT [EC:2.1.2.9]
synonym: "conversion of met-tRNAf to fmet-tRNA" RELATED [GO:curators]
synonym: "conversion of mitochondrial met-tRNAf to fmet-tRNA" RELATED [GO:curators]
synonym: "formylmethionyl-transfer ribonucleic synthetase activity" EXACT [EC:2.1.2.9]
synonym: "methionyl ribonucleic formyltransferase activity" EXACT [EC:2.1.2.9]
synonym: "methionyl-transfer ribonucleate methyltransferase activity" RELATED [EC:2.1.2.9]
synonym: "methionyl-transfer ribonucleic transformylase activity" EXACT [EC:2.1.2.9]
synonym: "methionyl-transfer RNA transformylase activity" EXACT [EC:2.1.2.9]
synonym: "methionyl-tRNA Met formyltransferase activity" EXACT [EC:2.1.2.9]
synonym: "methionyl-tRNA transformylase activity" EXACT [EC:2.1.2.9]
synonym: "mitochondrial N-terminal peptidyl-methionine N-formylation" RELATED [GO:curators]
synonym: "N(10)-formyltetrahydrofolic-methionyl-transfer ribonucleic transformylase activity" EXACT [EC:2.1.2.9]
synonym: "N-terminal peptidyl-methionine N-formylation" RELATED [GO:curators]
synonym: "N10-formyltetrahydrofolic-methionyl-transfer ribonucleic transformylase activity" EXACT [EC:2.1.2.9]
xref: EC:2.1.2.9
xref: MetaCyc:METHIONYL-TRNA-FORMYLTRANSFERASE-RXN
is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity
relationship: part_of GO:0006413 ! translational initiation
relationship: part_of GO:0071951 ! conversion of methionyl-tRNA to N-formyl-methionyl-tRNA

[Term]
id: GO:0004481
name: methylene-fatty-acyl-phospholipid synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid methylene fatty acid." [EC:2.1.1.16]
synonym: "cyclopropane synthetase activity" BROAD [EC:2.1.1.16]
synonym: "S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (methenylating)" EXACT [EC:2.1.1.16]
synonym: "unsaturated-phospholipid methyltransferase activity" BROAD [EC:2.1.1.16]
xref: EC:2.1.1.16
xref: MetaCyc:2.1.1.16-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0004482
name: mRNA (guanine-N7-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA. m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine." [EC:2.1.1.56]
synonym: "guanine-7-methyltransferase activity" EXACT [EC:2.1.1.56]
synonym: "messenger ribonucleate guanine 7-methyltransferase activity" EXACT [EC:2.1.1.56]
synonym: "messenger RNA guanine 7-methyltransferase activity" EXACT [EC:2.1.1.56]
synonym: "S-adenosyl-L-methionine:mRNA (guanine-7-N-)-methyltransferase activity" EXACT [EC:2.1.1.56]
synonym: "S-adenosyl-L-methionine:mRNA (guanine-N7-)-methyltransferase activity" EXACT [EC:2.1.1.56]
xref: EC:2.1.1.56
xref: MetaCyc:MRNA-GUANINE-N7--METHYLTRANSFERASE-RXN
xref: Reactome:REACT_109033 "Methylation of GMP-cap by RNA Methyltransferase, Gallus gallus"
xref: Reactome:REACT_30939 "Methylation of GMP-cap by RNA Methyltransferase, Rattus norvegicus"
xref: Reactome:REACT_34170 "Methylation of GMP-cap by RNA Methyltransferase, Caenorhabditis elegans"
xref: Reactome:REACT_404 "Methylation of GMP-cap by RNA Methyltransferase, Homo sapiens"
xref: Reactome:REACT_84965 "Methylation of GMP-cap by RNA Methyltransferase, Xenopus tropicalis"
xref: Reactome:REACT_87975 "Methylation of GMP-cap by RNA Methyltransferase, Mus musculus"
xref: Reactome:REACT_93915 "Methylation of GMP-cap by RNA Methyltransferase, Drosophila melanogaster"
xref: Reactome:REACT_96650 "Methylation of GMP-cap by RNA Methyltransferase, Oryza sativa"
xref: Reactome:REACT_97203 "Methylation of GMP-cap by RNA Methyltransferase, Danio rerio"
xref: Reactome:REACT_97945 "Methylation of GMP-cap by RNA Methyltransferase, Arabidopsis thaliana"
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0008174 ! mRNA methyltransferase activity
relationship: part_of GO:0006370 ! 7-methylguanosine mRNA capping
relationship: part_of GO:0036265 ! RNA (guanine-N7)-methylation

[Term]
id: GO:0004483
name: mRNA (nucleoside-2'-O-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + m7G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA. R may be guanosine or adenosine." [EC:2.1.1.57]
subset: gosubset_prok
synonym: "messenger ribonucleate nucleoside 2'-methyltransferase activity" EXACT [EC:2.1.1.57]
synonym: "messenger RNA (nucleoside-2'-)-methyltransferase activity" EXACT [EC:2.1.1.57]
synonym: "mRNA (adenosine-2'-O-)-methyltransferase activity" EXACT [EC:2.1.1.57]
synonym: "S-adenosyl-L-methionine:mRNA (nucleoside-2'-O-)-methyltransferase activity" EXACT [EC:2.1.1.57]
xref: EC:2.1.1.57
xref: MetaCyc:2.1.1.57-RXN
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0008174 ! mRNA methyltransferase activity

[Term]
id: GO:0004484
name: mRNA guanylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA; G(5')ppp-Pur-mRNA is mRNA containing a guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue." [EC:2.7.7.50]
synonym: "GTP--RNA guanylyltransferase activity" EXACT [EC:2.7.7.50]
synonym: "GTP:mRNA guanylyltransferase activity" EXACT []
synonym: "messenger RNA guanylyltransferase activity" EXACT [EC:2.7.7.50]
synonym: "mRNA capping enzyme activity" RELATED [EC:2.7.7.50]
synonym: "protein lambda2" RELATED [EC:2.7.7.50]
xref: EC:2.7.7.50
xref: MetaCyc:MRNA-GUANYLYLTRANSFERASE-RXN
xref: Reactome:REACT_101635 "Formation of the CE:GMP intermediate complex, Arabidopsis thaliana"
xref: Reactome:REACT_102473 "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA, Arabidopsis thaliana"
xref: Reactome:REACT_103446 "Formation of the CE:GMP intermediate complex, Schizosaccharomyces pombe"
xref: Reactome:REACT_103482 "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA, Oryza sativa"
xref: Reactome:REACT_107547 "Formation of the CE:GMP intermediate complex, Xenopus tropicalis"
xref: Reactome:REACT_108251 "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA, Canis familiaris"
xref: Reactome:REACT_110689 "Formation of the CE:GMP intermediate complex, Oryza sativa"
xref: Reactome:REACT_1580 "Formation of the CE:GMP intermediate complex, Homo sapiens"
xref: Reactome:REACT_1968 "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA, Homo sapiens"
xref: Reactome:REACT_32228 "Formation of the CE:GMP intermediate complex, Mus musculus"
xref: Reactome:REACT_36269 "Formation of the CE:GMP intermediate complex, Bos taurus"
xref: Reactome:REACT_77279 "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA, Drosophila melanogaster"
xref: Reactome:REACT_79193 "Formation of the CE:GMP intermediate complex, Caenorhabditis elegans"
xref: Reactome:REACT_79495 "Formation of the CE:GMP intermediate complex, Danio rerio"
xref: Reactome:REACT_80509 "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA, Dictyostelium discoideum"
xref: Reactome:REACT_82511 "Formation of the CE:GMP intermediate complex, Rattus norvegicus"
xref: Reactome:REACT_83926 "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA, Gallus gallus"
xref: Reactome:REACT_86486 "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA, Schizosaccharomyces pombe"
xref: Reactome:REACT_86857 "Formation of the CE:GMP intermediate complex, Gallus gallus"
xref: Reactome:REACT_88083 "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA, Saccharomyces cerevisiae"
xref: Reactome:REACT_88699 "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA, Bos taurus"
xref: Reactome:REACT_89040 "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA, Mus musculus"
xref: Reactome:REACT_90576 "Formation of the CE:GMP intermediate complex, Canis familiaris"
xref: Reactome:REACT_90910 "Formation of the CE:GMP intermediate complex, Saccharomyces cerevisiae"
xref: Reactome:REACT_92552 "Formation of the CE:GMP intermediate complex, Drosophila melanogaster"
xref: Reactome:REACT_93206 "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA, Rattus norvegicus"
xref: Reactome:REACT_93667 "Formation of the CE:GMP intermediate complex, Dictyostelium discoideum"
xref: Reactome:REACT_93676 "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA, Danio rerio"
xref: Reactome:REACT_95548 "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA, Caenorhabditis elegans"
xref: Reactome:REACT_97427 "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA, Xenopus tropicalis"
is_a: GO:0008192 ! RNA guanylyltransferase activity

[Term]
id: GO:0004485
name: methylcrotonoyl-CoA carboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-methylbut-2-enoyl-CoA + ATP + bicarbonate = trans-3-methylglutaconyl-CoA + ADP + 2 H(+) + phosphate." [EC:6.4.1.4, RHEA:13592]
subset: gosubset_prok
synonym: "3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)" EXACT [EC:6.4.1.4]
synonym: "beta-methylcrotonyl CoA carboxylase activity" EXACT [EC:6.4.1.4]
synonym: "beta-methylcrotonyl coenzyme A carboxylase activity" EXACT [EC:6.4.1.4]
synonym: "beta-methylcrotonyl-CoA carboxylase activity" EXACT [EC:6.4.1.4]
synonym: "methylcrotonyl coenzyme A carboxylase activity" EXACT [EC:6.4.1.4]
synonym: "methylcrotonyl-CoA carboxylase activity" EXACT [EC:6.4.1.4]
xref: EC:6.4.1.4
xref: KEGG:R04138
xref: MetaCyc:METHYLCROTONYL-COA-CARBOXYLASE-RXN
xref: Reactome:REACT_101781 "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA], Caenorhabditis elegans"
xref: Reactome:REACT_104589 "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA], Mus musculus"
xref: Reactome:REACT_109417 "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA], Canis familiaris"
xref: Reactome:REACT_112537 "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA], Mycobacterium tuberculosis"
xref: Reactome:REACT_1553 "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA], Homo sapiens"
xref: Reactome:REACT_21275 "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA], Homo sapiens"
xref: Reactome:REACT_32316 "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA], Rattus norvegicus"
xref: Reactome:REACT_34548 "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA], Drosophila melanogaster"
xref: Reactome:REACT_75262 "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA], Taeniopygia guttata"
xref: Reactome:REACT_80285 "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA], Dictyostelium discoideum"
xref: Reactome:REACT_82415 "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA], Oryza sativa"
xref: Reactome:REACT_83431 "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA], Gallus gallus"
xref: Reactome:REACT_90920 "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA], Xenopus tropicalis"
xref: Reactome:REACT_97131 "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA], Arabidopsis thaliana"
xref: Reactome:REACT_97587 "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA], Bos taurus"
xref: Reactome:REACT_97960 "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA], Danio rerio"
xref: RHEA:13592
is_a: GO:0016421 ! CoA carboxylase activity

[Term]
id: GO:0004486
name: methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(P)+ = 5,10-methenyltetrahydrofolate + NAD(P)H + H+." [EC:1.5.1.-, EC:1.5.1.15]
subset: gosubset_prok
synonym: "5,10-methylene-THF dehydrogenase activity" EXACT [GOC:vw]
synonym: "N5,N10-methylenetetrahydrofolate dehydrogenase activity" EXACT [EC:1.5.1.5]
xref: EC:1.5.1.-
xref: Reactome:REACT_101357 "5,10-methenylTHF polyglutamate + NADPH + H+ <=> 5,10-methyleneTHF polyglutamate + NADP+, Danio rerio"
xref: Reactome:REACT_104309 "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+, Saccharomyces cerevisiae"
xref: Reactome:REACT_106880 "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+, Rattus norvegicus"
xref: Reactome:REACT_110641 "5,10-methenylTHF polyglutamate + NADPH + H+ <=> 5,10-methyleneTHF polyglutamate + NADP+, Canis familiaris"
xref: Reactome:REACT_11187 "5,10-methenylTHF polyglutamate + NADPH + H+ <=> 5,10-methyleneTHF polyglutamate + NADP+, Homo sapiens"
xref: Reactome:REACT_11192 "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+, Homo sapiens"
xref: Reactome:REACT_112142 "5,10-methenylTHF polyglutamate + NADPH + H+ <=> 5,10-methyleneTHF polyglutamate + NADP+, Xenopus tropicalis"
xref: Reactome:REACT_114836 "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+, Xenopus tropicalis"
xref: Reactome:REACT_31299 "5,10-methenylTHF polyglutamate + NADPH + H+ <=> 5,10-methyleneTHF polyglutamate + NADP+, Rattus norvegicus"
xref: Reactome:REACT_32770 "5,10-methenylTHF polyglutamate + NADPH + H+ <=> 5,10-methyleneTHF polyglutamate + NADP+, Bos taurus"
xref: Reactome:REACT_33903 "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+, Taeniopygia guttata"
xref: Reactome:REACT_79639 "5,10-methenylTHF polyglutamate + NADPH + H+ <=> 5,10-methyleneTHF polyglutamate + NADP+, Mycobacterium tuberculosis"
xref: Reactome:REACT_82275 "5,10-methenylTHF polyglutamate + NADPH + H+ <=> 5,10-methyleneTHF polyglutamate + NADP+, Mus musculus"
xref: Reactome:REACT_82933 "5,10-methenylTHF polyglutamate + NADPH + H+ <=> 5,10-methyleneTHF polyglutamate + NADP+, Gallus gallus"
xref: Reactome:REACT_85239 "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+, Sus scrofa"
xref: Reactome:REACT_85625 "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+, Bos taurus"
xref: Reactome:REACT_86748 "5,10-methenylTHF polyglutamate + NADPH + H+ <=> 5,10-methyleneTHF polyglutamate + NADP+, Drosophila melanogaster"
xref: Reactome:REACT_89225 "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+, Gallus gallus"
xref: Reactome:REACT_90581 "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+, Canis familiaris"
xref: Reactome:REACT_91148 "5,10-methenylTHF polyglutamate + NADPH + H+ <=> 5,10-methyleneTHF polyglutamate + NADP+, Schizosaccharomyces pombe"
xref: Reactome:REACT_91334 "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+, Schizosaccharomyces pombe"
xref: Reactome:REACT_91781 "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+, Mycobacterium tuberculosis"
xref: Reactome:REACT_95519 "5,10-methenylTHF polyglutamate + NADPH + H+ <=> 5,10-methyleneTHF polyglutamate + NADP+, Taeniopygia guttata"
xref: Reactome:REACT_95885 "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+, Drosophila melanogaster"
xref: Reactome:REACT_96601 "5,10-methenylTHF polyglutamate + NADPH + H+ <=> 5,10-methyleneTHF polyglutamate + NADP+, Sus scrofa"
xref: Reactome:REACT_96737 "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+, Mus musculus"
xref: Reactome:REACT_97838 "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+, Danio rerio"
xref: Reactome:REACT_99193 "5,10-methenylTHF polyglutamate + NADPH + H+ <=> 5,10-methyleneTHF polyglutamate + NADP+, Saccharomyces cerevisiae"
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004487
name: methylenetetrahydrofolate dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(+) = 5,10-methenyltetrahydrofolate + NADH." [EC:1.5.1.15, RHEA:22895]
synonym: "5,10-methylenetetrahydrofolate dehydrogenase activity" EXACT [EC:1.5.1.5]
synonym: "5,10-methylenetetrahydrofolate:NAD+ oxidoreductase" EXACT [EC:1.5.1.15]
xref: EC:1.5.1.15
xref: KEGG:R01218
xref: MetaCyc:1.5.1.15-RXN
xref: RHEA:22895
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004488
name: methylenetetrahydrofolate dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH." [EC:1.5.1.5, RHEA:22815]
subset: gosubset_prok
synonym: "5,10-methylenetetrahydrofolate:NADP oxidoreductase activity" EXACT [EC:1.5.1.5]
synonym: "5,10-methylenetetrahydrofolate:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.5]
xref: EC:1.5.1.5
xref: KEGG:R01220
xref: MetaCyc:METHYLENETHFDEHYDROG-NADP-RXN
xref: RHEA:22815
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004489
name: methylenetetrahydrofolate reductase (NAD(P)H) activity
namespace: molecular_function
alt_id: GO:0008702
def: "Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+." [EC:1.5.1.20]
comment: Includes EC 1.7.99.5.
subset: gosubset_prok
synonym: "1.7.99.5" RELATED []
synonym: "5,10-CH(2)-H(4)folate reductase activity" EXACT [EC:1.5.1.20]
synonym: "5,10-CH2-H4folate reductase activity" EXACT [EC:1.5.1.20]
synonym: "5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [EC:1.5.1.20]
synonym: "5,10-methylenetetrahydrofolate reductase (FADH) activity" EXACT []
synonym: "5,10-methylenetetrahydrofolate reductase (FADH2) activity" EXACT []
synonym: "5,10-methylenetetrahydrofolate reductase (NADPH) activity" EXACT [EC:1.5.1.20]
synonym: "5,10-methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.1.20]
synonym: "5,10-methylenetetrahydrofolic acid reductase activity" BROAD [EC:1.5.1.20]
synonym: "5,10-methylenetetrahydropteroylglutamate reductase activity" EXACT [EC:1.5.1.20]
synonym: "5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" EXACT [EC:1.5.1.20]
synonym: "5-methyltetrahydrofolate:NAD oxidoreductase activity" EXACT [EC:1.5.1.20]
synonym: "5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" EXACT [EC:1.5.1.20]
synonym: "5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.5.1.20]
synonym: "5-methyltetrahydrofolate:NAD+ oxidoreductase activity" EXACT [EC:1.5.1.20]
synonym: "5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" EXACT [EC:1.5.1.20]
synonym: "5-methyltetrahydrofolate:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.20]
synonym: "MetF" RELATED [EC:1.5.1.20]
synonym: "methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.5.1.20]
synonym: "methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [EC:1.5.1.20]
synonym: "methylenetetrahydrofolate reductase (NADPH(2)) activity" EXACT [EC:1.5.1.20]
synonym: "methylenetetrahydrofolate reductase (NADPH2)" EXACT [EC:1.5.1.20]
synonym: "methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [EC:1.5.1.20]
synonym: "methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.1.20]
synonym: "methylenetetrahydrofolic acid reductase activity" BROAD [EC:1.5.1.20]
synonym: "MTHFR activity" BROAD [EC:1.5.1.20]
synonym: "N(5),N(10)-methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.1.20]
synonym: "N(5,10)-methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.1.20]
synonym: "N5,10-methylenetetrahydrofolate reductase activity" EXACT [EC:1.5.1.20]
synonym: "N5,N10-methylenetetrahydrofolate reductase activity" EXACT [EC:1.5.1.20]
xref: EC:1.5.1.20
xref: KEGG:R01224
xref: KEGG:R07168
xref: MetaCyc:1.5.1.20-RXN
xref: Reactome:REACT_100929 "5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+, Sus scrofa"
xref: Reactome:REACT_102712 "5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+, Gallus gallus"
xref: Reactome:REACT_106752 "5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+, Taeniopygia guttata"
xref: Reactome:REACT_106770 "5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+, Dictyostelium discoideum"
xref: Reactome:REACT_109034 "5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+, Xenopus tropicalis"
xref: Reactome:REACT_110093 "5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+, Danio rerio"
xref: Reactome:REACT_110152 "5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+, Mus musculus"
xref: Reactome:REACT_11102 "5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+, Homo sapiens"
xref: Reactome:REACT_29352 "5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+, Rattus norvegicus"
xref: Reactome:REACT_30478 "5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+, Canis familiaris"
xref: Reactome:REACT_33585 "5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+, Escherichia coli"
xref: Reactome:REACT_78371 "5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+, Caenorhabditis elegans"
xref: Reactome:REACT_96333 "5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+, Bos taurus"
xref: Reactome:REACT_97871 "5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+, Oryza sativa"
xref: Reactome:REACT_98681 "5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+, Drosophila melanogaster"
xref: RHEA:19820
xref: RHEA:19824
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004490
name: methylglutaconyl-CoA hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = trans-3-methylglutaconyl-CoA + H(2)O." [EC:4.2.1.18, RHEA:21539]
subset: gosubset_prok
synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase (trans-3-methylglutaconyl-CoA-forming)" EXACT [EC:4.2.1.18]
synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase activity" EXACT [EC:4.2.1.18]
synonym: "3-methylglutaconyl CoA hydratase activity" EXACT [EC:4.2.1.18]
synonym: "methylglutaconase activity" EXACT [EC:4.2.1.18]
synonym: "methylglutaconyl coenzyme A hydratase activity" EXACT [EC:4.2.1.18]
xref: EC:4.2.1.18
xref: KEGG:R02085
xref: MetaCyc:METHYLGLUTACONYL-COA-HYDRATASE-RXN
xref: Reactome:REACT_101172 "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA, Gallus gallus"
xref: Reactome:REACT_101430 "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA, Caenorhabditis elegans"
xref: Reactome:REACT_104594 "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA, Arabidopsis thaliana"
xref: Reactome:REACT_106638 "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA, Danio rerio"
xref: Reactome:REACT_114406 "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA, Mycobacterium tuberculosis"
xref: Reactome:REACT_1157 "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA, Homo sapiens"
xref: Reactome:REACT_77810 "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA, Xenopus tropicalis"
xref: Reactome:REACT_79310 "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA, Rattus norvegicus"
xref: Reactome:REACT_83854 "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA, Oryza sativa"
xref: Reactome:REACT_83970 "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA, Sus scrofa"
xref: Reactome:REACT_89339 "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA, Drosophila melanogaster"
xref: Reactome:REACT_91926 "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA, Taeniopygia guttata"
xref: Reactome:REACT_93670 "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA, Mus musculus"
xref: Reactome:REACT_96751 "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA, Dictyostelium discoideum"
xref: Reactome:REACT_97337 "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA, Bos taurus"
xref: RHEA:21539
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0004491
name: methylmalonate-semialdehyde dehydrogenase (acylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+." [EC:1.2.1.27]
subset: gosubset_prok
synonym: "2-methyl-3-oxopropanoate:NAD+ 3-oxidoreductase (CoA-propanoylating)" EXACT [EC:1.2.1.27]
synonym: "MMSA dehydrogenase activity" EXACT [EC:1.2.1.27]
synonym: "MSDH activity" EXACT [EC:1.2.1.27]
xref: EC:1.2.1.27
xref: MetaCyc:1.2.1.27-RXN
xref: Reactome:REACT_100756 "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+, Oryza sativa"
xref: Reactome:REACT_101467 "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+, Arabidopsis thaliana"
xref: Reactome:REACT_101605 "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+, Taeniopygia guttata"
xref: Reactome:REACT_103353 "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+, Dictyostelium discoideum"
xref: Reactome:REACT_104811 "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+, Gallus gallus"
xref: Reactome:REACT_1077 "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+, Homo sapiens"
xref: Reactome:REACT_28561 "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+, Mycobacterium tuberculosis"
xref: Reactome:REACT_30813 "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+, Canis familiaris"
xref: Reactome:REACT_32679 "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+, Sus scrofa"
xref: Reactome:REACT_81708 "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+, Mus musculus"
xref: Reactome:REACT_84411 "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+, Xenopus tropicalis"
xref: Reactome:REACT_84866 "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+, Danio rerio"
xref: Reactome:REACT_86537 "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+, Caenorhabditis elegans"
xref: Reactome:REACT_89741 "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+, Rattus norvegicus"
xref: Reactome:REACT_95710 "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+, Drosophila melanogaster"
xref: Reactome:REACT_99224 "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+, Bos taurus"
xref: RHEA:20807
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004492
name: methylmalonyl-CoA decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-2-methyl-3-oxopropanoyl-CoA = propanoyl-CoA + CO2." [EC:4.1.1.41]
subset: gosubset_prok
synonym: "(S)-2-methyl-3-oxopropanoyl-CoA carboxy-lyase activity" EXACT [EC:4.1.1.41]
synonym: "(S)-methylmalonyl-CoA carboxy-lyase (propanoyl-CoA-forming)" EXACT [EC:4.1.1.41]
synonym: "(S)-methylmalonyl-CoA carboxy-lyase activity" EXACT [EC:4.1.1.41]
synonym: "methylmalonyl-coenzyme A decarboxylase activity" EXACT [EC:4.1.1.41]
xref: EC:4.1.1.41
xref: MetaCyc:METHYLMALONYL-COA-DECARBOXYLASE-RXN
xref: RHEA:21399
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004493
name: methylmalonyl-CoA epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA." [EC:5.1.99.1, RHEA:20556]
subset: gosubset_prok
synonym: "2-methyl-3-oxopropanoyl-CoA 2-epimerase activity" EXACT [EC:5.1.99.1]
synonym: "DL-methylmalonyl-CoA racemase activity" EXACT [EC:5.1.99.1]
synonym: "methylmalonyl coenzyme A racemase activity" EXACT [EC:5.1.99.1]
synonym: "methylmalonyl-CoA 2-epimerase activity" EXACT [EC:5.1.99.1]
synonym: "methylmalonyl-CoA racemase activity" EXACT [EC:5.1.99.1]
xref: EC:5.1.99.1
xref: KEGG:R02765
xref: MetaCyc:METHYLMALONYL-COA-EPIM-RXN
xref: Reactome:REACT_100697 "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA, Mycobacterium tuberculosis"
xref: Reactome:REACT_102795 "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA, Danio rerio"
xref: Reactome:REACT_104215 "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA, Caenorhabditis elegans"
xref: Reactome:REACT_104256 "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA, Gallus gallus"
xref: Reactome:REACT_1909 "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA, Homo sapiens"
xref: Reactome:REACT_32244 "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA, Canis familiaris"
xref: Reactome:REACT_32925 "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA, Rattus norvegicus"
xref: Reactome:REACT_62113 "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA, Bos taurus"
xref: Reactome:REACT_84891 "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA, Xenopus tropicalis"
xref: Reactome:REACT_86324 "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA, Sus scrofa"
xref: Reactome:REACT_95035 "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA, Mus musculus"
xref: Reactome:REACT_95506 "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA, Taeniopygia guttata"
xref: Reactome:REACT_96525 "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA, Dictyostelium discoideum"
xref: RHEA:20556
is_a: GO:0016854 ! racemase and epimerase activity

[Term]
id: GO:0004494
name: methylmalonyl-CoA mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-methylmalonyl-CoA = succinyl-CoA." [EC:5.4.99.2, RHEA:22891]
subset: gosubset_prok
synonym: "(R)-2-methyl-3-oxopropanoyl-CoA CoA-carbonylmutase activity" EXACT [EC:5.4.99.2]
synonym: "(R)-methylmalonyl-CoA CoA-carbonylmutase activity" EXACT [EC:5.4.99.2]
synonym: "(S)-methylmalonyl-CoA mutase activity" EXACT [EC:5.4.99.2]
synonym: "methylmalonyl coenzyme A carbonylmutase activity" EXACT [EC:5.4.99.2]
synonym: "methylmalonyl coenzyme A mutase activity" EXACT [EC:5.4.99.2]
synonym: "methylmalonyl-CoA CoA-carbonyl mutase activity" EXACT [EC:5.4.99.2]
xref: EC:5.4.99.2
xref: KEGG:R00833
xref: MetaCyc:METHYLMALONYL-COA-MUT-RXN
xref: Reactome:REACT_110753 "L-methylmalonyl-CoA <=> succinyl-CoA, Canis familiaris"
xref: Reactome:REACT_114493 "L-methylmalonyl-CoA <=> succinyl-CoA, Xenopus tropicalis"
xref: Reactome:REACT_19 "L-methylmalonyl-CoA <=> succinyl-CoA, Homo sapiens"
xref: Reactome:REACT_28603 "L-methylmalonyl-CoA <=> succinyl-CoA, Dictyostelium discoideum"
xref: Reactome:REACT_30850 "L-methylmalonyl-CoA <=> succinyl-CoA, Gallus gallus"
xref: Reactome:REACT_32125 "L-methylmalonyl-CoA <=> succinyl-CoA, Bos taurus"
xref: Reactome:REACT_33463 "L-methylmalonyl-CoA <=> succinyl-CoA, Rattus norvegicus"
xref: Reactome:REACT_35053 "L-methylmalonyl-CoA <=> succinyl-CoA, Caenorhabditis elegans"
xref: Reactome:REACT_86041 "L-methylmalonyl-CoA <=> succinyl-CoA, Escherichia coli"
xref: Reactome:REACT_86718 "L-methylmalonyl-CoA <=> succinyl-CoA, Taeniopygia guttata"
xref: Reactome:REACT_87467 "L-methylmalonyl-CoA <=> succinyl-CoA, Mycobacterium tuberculosis"
xref: Reactome:REACT_95870 "L-methylmalonyl-CoA <=> succinyl-CoA, Sus scrofa"
xref: Reactome:REACT_97766 "L-methylmalonyl-CoA <=> succinyl-CoA, Danio rerio"
xref: Reactome:REACT_98331 "L-methylmalonyl-CoA <=> succinyl-CoA, Mus musculus"
xref: RHEA:22891
xref: UM-BBD_reactionID:r0922
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0004495
name: mevaldate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-mevalonate + acceptor = mevaldate + reduced acceptor." [EC:1.1.1.32, EC:1.1.1.33]
xref: EC:1.1.1.-
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004496
name: mevalonate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + 2 H(+)." [EC:2.7.1.36, RHEA:17068]
subset: gosubset_prok
synonym: "ATP:(R)-mevalonate 5-phosphotransferase activity" EXACT [EC:2.7.1.36]
synonym: "ATP:mevalonate 5-phosphotransferase activity" EXACT [EC:2.7.1.36]
synonym: "mevalonate 5-phosphotransferase activity" EXACT [EC:2.7.1.36]
synonym: "mevalonate kinase (phosphorylating)" EXACT [EC:2.7.1.36]
synonym: "mevalonate phosphokinase activity" EXACT [EC:2.7.1.36]
synonym: "mevalonic acid kinase activity" EXACT [EC:2.7.1.36]
synonym: "mevalonic kinase activity" EXACT [EC:2.7.1.36]
synonym: "MVA kinase activity" EXACT [EC:2.7.1.36]
xref: EC:2.7.1.36
xref: KEGG:R02245
xref: MetaCyc:MEVALONATE-KINASE-RXN
xref: Reactome:REACT_101004 "Mevalonate is phosphorylated to mevalonate-5-phosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_101608 "Mevalonate is phosphorylated to mevalonate-5-phosphate, Bos taurus"
xref: Reactome:REACT_102374 "Mevalonate is phosphorylated to mevalonate-5-phosphate, Taeniopygia guttata"
xref: Reactome:REACT_104390 "Mevalonate is phosphorylated to mevalonate-5-phosphate, Xenopus tropicalis"
xref: Reactome:REACT_105718 "Mevalonate is phosphorylated to mevalonate-5-phosphate, Drosophila melanogaster"
xref: Reactome:REACT_107959 "Mevalonate is phosphorylated to mevalonate-5-phosphate, Mus musculus"
xref: Reactome:REACT_110994 "Mevalonate is phosphorylated to mevalonate-5-phosphate, Sus scrofa"
xref: Reactome:REACT_29025 "Mevalonate is phosphorylated to mevalonate-5-phosphate, Danio rerio"
xref: Reactome:REACT_30351 "Mevalonate is phosphorylated to mevalonate-5-phosphate, Dictyostelium discoideum"
xref: Reactome:REACT_33985 "Mevalonate is phosphorylated to mevalonate-5-phosphate, Canis familiaris"
xref: Reactome:REACT_78740 "Mevalonate is phosphorylated to mevalonate-5-phosphate, Oryza sativa"
xref: Reactome:REACT_80823 "Mevalonate is phosphorylated to mevalonate-5-phosphate, Staphylococcus aureus N315"
xref: Reactome:REACT_81000 "Mevalonate is phosphorylated to mevalonate-5-phosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_87306 "Mevalonate is phosphorylated to mevalonate-5-phosphate, Gallus gallus"
xref: Reactome:REACT_9448 "Mevalonate is phosphorylated to mevalonate-5-phosphate, Homo sapiens"
xref: Reactome:REACT_95202 "Mevalonate is phosphorylated to mevalonate-5-phosphate, Arabidopsis thaliana"
xref: Reactome:REACT_98858 "Mevalonate is phosphorylated to mevalonate-5-phosphate, Caenorhabditis elegans"
xref: RHEA:17068
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0004497
name: monooxygenase activity
namespace: molecular_function
def: "Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
synonym: "hydroxylase activity" RELATED [GOC:mah, GOC:vk]
xref: Reactome:REACT_100875 "FMO2 S-oxidizes the antithyroid drug methimazole, Dictyostelium discoideum"
xref: Reactome:REACT_101711 "CYP2W1 can oxidize indole, Sus scrofa"
xref: Reactome:REACT_106539 "CYP3A43 catalyzes the 6beta-hydroxylation of testosterone, Gallus gallus"
xref: Reactome:REACT_106973 "CYP2W1 can oxidize indole, Mus musculus"
xref: Reactome:REACT_107936 "FMO2 S-oxidizes the antithyroid drug methimazole, Caenorhabditis elegans"
xref: Reactome:REACT_109390 "CYP4F11 omega-hydroxylates 3-hydroxypalmitate, Mus musculus"
xref: Reactome:REACT_110926 "CYP2W1 can oxidize indole, Danio rerio"
xref: Reactome:REACT_113028 "CYP3A43 catalyzes the 6beta-hydroxylation of testosterone, Taeniopygia guttata"
xref: Reactome:REACT_115238 "FMO2 S-oxidizes the antithyroid drug methimazole, Danio rerio"
xref: Reactome:REACT_13511 "CYP4F11 omega-hydroxylates 3-hydroxypalmitate, Homo sapiens"
xref: Reactome:REACT_13592 "CYP2W1 can oxidize indole, Homo sapiens"
xref: Reactome:REACT_13740 "CYP3A43 catalyzes the 6beta-hydroxylation of testosterone, Homo sapiens"
xref: Reactome:REACT_13821 "FMO2 S-oxidizes the antithyroid drug methimazole, Homo sapiens"
xref: Reactome:REACT_30553 "FMO2 S-oxidizes the antithyroid drug methimazole, Canis familiaris"
xref: Reactome:REACT_34685 "FMO2 S-oxidizes the antithyroid drug methimazole, Mus musculus"
xref: Reactome:REACT_78030 "CYP4F11 omega-hydroxylates 3-hydroxypalmitate, Danio rerio"
xref: Reactome:REACT_79048 "CYP3A43 catalyzes the 6beta-hydroxylation of testosterone, Danio rerio"
xref: Reactome:REACT_80846 "CYP2W1 can oxidize indole, Canis familiaris"
xref: Reactome:REACT_82079 "CYP2W1 can oxidize indole, Xenopus tropicalis"
xref: Reactome:REACT_84097 "FMO2 S-oxidizes the antithyroid drug methimazole, Bos taurus"
xref: Reactome:REACT_84242 "CYP2W1 can oxidize indole, Gallus gallus"
xref: Reactome:REACT_86917 "CYP2W1 can oxidize indole, Rattus norvegicus"
xref: Reactome:REACT_88779 "CYP4F11 omega-hydroxylates 3-hydroxypalmitate, Xenopus tropicalis"
xref: Reactome:REACT_90320 "CYP4F11 omega-hydroxylates 3-hydroxypalmitate, Taeniopygia guttata"
xref: Reactome:REACT_90960 "CYP3A43 catalyzes the 6beta-hydroxylation of testosterone, Drosophila melanogaster"
xref: Reactome:REACT_90990 "CYP2W1 can oxidize indole, Bos taurus"
xref: Reactome:REACT_92968 "FMO2 S-oxidizes the antithyroid drug methimazole, Sus scrofa"
xref: Reactome:REACT_95195 "FMO2 S-oxidizes the antithyroid drug methimazole, Rattus norvegicus"
xref: Reactome:REACT_96655 "CYP3A43 catalyzes the 6beta-hydroxylation of testosterone, Mus musculus"
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0004498
name: calcidiol 1-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: calcidiol + H(+) + NADPH + O(2) = calcitriol + H(2)O + NADP(+)." [EC:1.14.13.13, RHEA:20576]
synonym: "1-hydroxylase-25-hydroxyvitamin D3 activity" RELATED [EC:1.14.13.13]
synonym: "25-hydroxy D3-1alpha-hydroxylase activity" EXACT [EC:1.14.13.13]
synonym: "25-hydroxy vitamin D3 1-alpha-hydroxylase activity" EXACT []
synonym: "25-hydroxycholecalciferol 1-hydroxylase activity" EXACT []
synonym: "25-hydroxycholecalciferol 1-monooxygenase activity" EXACT [EC:1.14.13.13]
synonym: "25-hydroxycholecalciferol 1alpha-hydroxylase activity" EXACT [EC:1.14.13.13]
synonym: "25-hydroxycholecalciferol-1-hydroxylase activity" EXACT [EC:1.14.13.13]
synonym: "25-hydroxyvitamin D-1 alpha hydroxylase activity" EXACT [EC:1.14.13.13]
synonym: "25-hydroxyvitamin D3 1alpha-hydroxylase activity" EXACT [EC:1.14.13.13]
synonym: "25-OHD-1 alpha-hydroxylase activity" EXACT [EC:1.14.13.13]
synonym: "calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating)" EXACT [EC:1.14.13.13]
synonym: "cytochrome P450 CYP27B" NARROW []
xref: EC:1.14.13.13
xref: KEGG:R03610
xref: MetaCyc:CALCIDIOL-1-MONOOXYGENASE-RXN
xref: Reactome:REACT_102929 "Further hydroxylation of calcidiol in kidney to form calcitriol, Danio rerio"
xref: Reactome:REACT_106826 "Further hydroxylation of calcidiol in kidney to form calcitriol, Drosophila melanogaster"
xref: Reactome:REACT_110331 "Further hydroxylation of calcidiol in kidney to form calcitriol, Canis familiaris"
xref: Reactome:REACT_13628 "Further hydroxylation of calcidiol in kidney to form calcitriol, Homo sapiens"
xref: Reactome:REACT_83168 "Further hydroxylation of calcidiol in kidney to form calcitriol, Xenopus tropicalis"
xref: Reactome:REACT_84663 "Further hydroxylation of calcidiol in kidney to form calcitriol, Bos taurus"
xref: Reactome:REACT_93300 "Further hydroxylation of calcidiol in kidney to form calcitriol, Mus musculus"
xref: RHEA:20576
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
relationship: part_of GO:0036378 ! calcitriol biosynthetic process from calciol

[Term]
id: GO:0004499
name: N,N-dimethylaniline monooxygenase activity
namespace: molecular_function
alt_id: GO:0047076
def: "Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O." [EC:1.14.13.8]
subset: gosubset_prok
synonym: "1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine:oxygen N-oxidoreductase activity" EXACT [EC:1.13.12.11]
synonym: "dimethylaniline monooxygenase (N-oxide-forming) activity" EXACT []
synonym: "dimethylaniline N-oxidase activity" EXACT [EC:1.13.12.11]
synonym: "dimethylaniline oxidase activity" EXACT [EC:1.13.12.11]
synonym: "DMA oxidase activity" EXACT [EC:1.13.12.11]
synonym: "FAD-containing monooxygenase activity" RELATED [EC:1.13.12.11]
synonym: "flavin mixed function oxidase activity" RELATED [EC:1.13.12.11]
synonym: "flavin monooxygenase activity" RELATED [EC:1.13.12.11]
synonym: "flavin-containing monooxygenase activity" BROAD [EC:1.13.12.11]
synonym: "FMO activity" RELATED [EC:1.13.12.11]
synonym: "FMO-I" RELATED [EC:1.13.12.11]
synonym: "FMO-II" RELATED [EC:1.13.12.11]
synonym: "FMO1" RELATED [EC:1.13.12.11]
synonym: "FMO2" RELATED [EC:1.13.12.11]
synonym: "FMO3" RELATED [EC:1.13.12.11]
synonym: "FMO4" RELATED [EC:1.13.12.11]
synonym: "FMO5" RELATED [EC:1.13.12.11]
synonym: "methylphenyltetrahydropyridine N-monooxygenase activity" EXACT []
synonym: "mixed-function amine oxidase activity" RELATED [EC:1.13.12.11]
synonym: "N,N-dimethylaniline,NADPH:oxygen oxidoreductase (N-oxide-forming)" EXACT [EC:1.13.12.11]
synonym: "Ziegler's enzyme" RELATED [EC:1.13.12.11]
xref: EC:1.14.13.8
xref: MetaCyc:1.14.13.8-RXN
xref: Reactome:REACT_101564 "FMO1 N-oxidizes the anti-cancer drug tamoxifen, Bos taurus"
xref: Reactome:REACT_105482 "FMO3 N-oxidizes the tertiary amine trimethylamine, Sus scrofa"
xref: Reactome:REACT_108626 "FMO3 N-oxidizes the tertiary amine trimethylamine, Mus musculus"
xref: Reactome:REACT_109888 "FMO1 N-oxidizes the anti-cancer drug tamoxifen, Sus scrofa"
xref: Reactome:REACT_110026 "FMO1 N-oxidizes the anti-cancer drug tamoxifen, Rattus norvegicus"
xref: Reactome:REACT_110579 "FMO1 N-oxidizes the anti-cancer drug tamoxifen, Caenorhabditis elegans"
xref: Reactome:REACT_113438 "FMO3 N-oxidizes the tertiary amine trimethylamine, Taeniopygia guttata"
xref: Reactome:REACT_114014 "FMO1 N-oxidizes the anti-cancer drug tamoxifen, Danio rerio"
xref: Reactome:REACT_114556 "FMO3 N-oxidizes the tertiary amine trimethylamine, Danio rerio"
xref: Reactome:REACT_13805 "FMO1 N-oxidizes the anti-cancer drug tamoxifen, Homo sapiens"
xref: Reactome:REACT_236 "FMO3 N-oxidizes the tertiary amine trimethylamine, Homo sapiens"
xref: Reactome:REACT_45115 "FMO1 N-oxidizes the anti-cancer drug tamoxifen, Mus musculus"
xref: Reactome:REACT_80104 "FMO3 N-oxidizes the tertiary amine trimethylamine, Dictyostelium discoideum"
xref: Reactome:REACT_80941 "FMO3 N-oxidizes the tertiary amine trimethylamine, Canis familiaris"
xref: Reactome:REACT_84504 "FMO1 N-oxidizes the anti-cancer drug tamoxifen, Dictyostelium discoideum"
xref: Reactome:REACT_87365 "FMO3 N-oxidizes the tertiary amine trimethylamine, Xenopus tropicalis"
xref: Reactome:REACT_91809 "FMO3 N-oxidizes the tertiary amine trimethylamine, Gallus gallus"
xref: Reactome:REACT_95881 "FMO3 N-oxidizes the tertiary amine trimethylamine, Rattus norvegicus"
xref: Reactome:REACT_97774 "FMO3 N-oxidizes the tertiary amine trimethylamine, Caenorhabditis elegans"
xref: Reactome:REACT_99402 "FMO1 N-oxidizes the anti-cancer drug tamoxifen, Canis familiaris"
xref: RHEA:24471
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0004500
name: dopamine beta-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-ascorbate + dopamine + O(2) = (R)-noradrenaline + dehydroascorbate + H(2)O." [EC:1.14.17.1, RHEA:19120]
subset: gosubset_prok
synonym: "(3,4-dihydroxyphenethylamine)beta-mono-oxygenase activity" EXACT [EC:1.14.17.1]
synonym: "3,4-dihydroxyphenethylamine beta-oxidase activity" EXACT [EC:1.14.17.1]
synonym: "3,4-dihydroxyphenethylamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)" EXACT [EC:1.14.17.1]
synonym: "4-(2-aminoethyl)pyrocatechol beta-oxidase activity" EXACT [EC:1.14.17.1]
synonym: "dopa beta-hydroxylase activity" EXACT [EC:1.14.17.1]
synonym: "dopamine b-hydroxylase activity" EXACT []
synonym: "dopamine beta-hydroxylase activity" EXACT [EC:1.14.17.1]
synonym: "dopamine beta-oxidase activity" EXACT [EC:1.14.17.1]
synonym: "dopamine hydroxylase activity" EXACT [EC:1.14.17.1]
synonym: "dopamine-B-hydroxylase activity" EXACT [EC:1.14.17.1]
synonym: "MDBH (membrane-associated dopamine beta-monooxygenase)" RELATED [EC:1.14.17.1]
synonym: "oxygenase, dopamine beta-mono-" EXACT [EC:1.14.17.1]
synonym: "phenylamine beta-hydroxylase activity" EXACT [EC:1.14.17.1]
synonym: "SDBH (soluble dopamine beta-monooxygenase)" RELATED [EC:1.14.17.1]
xref: EC:1.14.17.1
xref: KEGG:R02535
xref: MetaCyc:DOPAMINE-BETA-MONOOXYGENASE-RXN
xref: Reactome:REACT_105580 "Dopamine is oxidised to noradrenaline, Bos taurus"
xref: Reactome:REACT_106750 "Dopamine is oxidised to noradrenaline, Mus musculus"
xref: Reactome:REACT_15372 "Dopamine is oxidised to noradrenaline, Homo sapiens"
xref: Reactome:REACT_28248 "Dopamine is oxidised to noradrenaline, Xenopus tropicalis"
xref: Reactome:REACT_29465 "Dopamine is oxidised to noradrenaline, Rattus norvegicus"
xref: Reactome:REACT_32682 "Dopamine is oxidised to noradrenaline, Drosophila melanogaster"
xref: Reactome:REACT_79735 "Dopamine is oxidised to noradrenaline, Canis familiaris"
xref: Reactome:REACT_80521 "Dopamine is oxidised to noradrenaline, Sus scrofa"
xref: Reactome:REACT_80863 "Dopamine is oxidised to noradrenaline, Gallus gallus"
xref: Reactome:REACT_89497 "Dopamine is oxidised to noradrenaline, Taeniopygia guttata"
xref: Reactome:REACT_92696 "Dopamine is oxidised to noradrenaline, Caenorhabditis elegans"
xref: Reactome:REACT_98351 "Dopamine is oxidised to noradrenaline, Danio rerio"
xref: RHEA:19120
is_a: GO:0016715 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0004501
name: ecdysone 20-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: AH(2) + Ecdysone + O(2) = 20-hydroxyecdysone + A + H(2)O." [EC:1.14.99.22, RHEA:14024]
synonym: "alpha-ecdysone C-20 hydroxylase activity" EXACT [EC:1.14.99.22]
synonym: "ecdysone 20-hydroxylase activity" EXACT []
synonym: "ecdysone modification" BROAD []
synonym: "ecdysone,hydrogen-donor:oxygen oxidoreductase (20-hydroxylating)" EXACT [EC:1.14.99.22]
xref: EC:1.14.99.22
xref: KEGG:R02374
xref: MetaCyc:ECDYSONE-20-MONOOXYGENASE-RXN
xref: RHEA:14024
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0004502
name: kynurenine 3-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-kynurenine + H(+) + NADPH + O(2) = 3-hydroxy-L-kynurenine + H(2)O + NADP(+)." [EC:1.14.13.9, RHEA:20548]
subset: gosubset_prok
synonym: "kynurenine 3-hydroxylase activity" EXACT []
synonym: "kynurenine hydroxylase activity" EXACT [EC:1.14.13.9]
synonym: "L-kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.9]
synonym: "L-kynurenine-3-hydroxylase activity" EXACT [EC:1.14.13.9]
xref: EC:1.14.13.9
xref: KEGG:R01960
xref: MetaCyc:KYNURENINE-3-MONOOXYGENASE-RXN
xref: Reactome:REACT_100337 "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O, Mus musculus"
xref: Reactome:REACT_100740 "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O, Caenorhabditis elegans"
xref: Reactome:REACT_108549 "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O, Bos taurus"
xref: Reactome:REACT_109130 "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O, Danio rerio"
xref: Reactome:REACT_79840 "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O, Dictyostelium discoideum"
xref: Reactome:REACT_79885 "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O, Taeniopygia guttata"
xref: Reactome:REACT_82021 "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O, Rattus norvegicus"
xref: Reactome:REACT_84641 "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O, Saccharomyces cerevisiae"
xref: Reactome:REACT_86351 "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O, Xenopus tropicalis"
xref: Reactome:REACT_90028 "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O, Canis familiaris"
xref: Reactome:REACT_927 "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O, Homo sapiens"
xref: Reactome:REACT_96923 "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O, Drosophila melanogaster"
xref: Reactome:REACT_98896 "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O, Gallus gallus"
xref: RHEA:20548
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0004503
name: monophenol monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tyrosine + L-DOPA + O2 = L-DOPA + DOPAquinone + H2O." [EC:1.14.18.1, GOC:bf, GOC:sart, PMID:4965136]
comment: In mammals, L-DOPA can act as a cofactor for the catalyzed reaction; therefore in some resources L-DOPA is shown on both sides of the reaction. GO:0004503 describes the monooxygenation of the monophenol, L-tyrosine. For oxidation of diphenols (including L-DOPA and dopamine), consider instead the term 'catechol oxidase activity ; GO:0004097' and its children.
subset: gosubset_prok
synonym: "catecholase" RELATED [EC:1.14.18.1]
synonym: "chlorogenic acid oxidase activity" RELATED [EC:1.14.18.1]
synonym: "chlorogenic oxidase activity" RELATED [EC:1.14.18.1]
synonym: "cresolase activity" RELATED [EC:1.14.18.1]
synonym: "dopa oxidase" RELATED [EC:1.14.18.1]
synonym: "L-tyrosine monooxygenase activity" EXACT [GOC:bf]
synonym: "monophenol dihydroxyphenylalanine:oxygen oxidoreductase activity" EXACT [EC:1.14.18.1]
synonym: "monophenol monooxidase activity" EXACT [EC:1.14.18.1]
synonym: "monophenol oxidase activity" EXACT [EC:1.14.18.1]
synonym: "monophenol oxygenase" EXACT [PMID:2494997]
synonym: "monophenol, dihydroxy-L-phenylalanine oxygen oxidoreductase activity" EXACT [EC:1.14.18.1]
synonym: "monophenol,L-dopa:oxygen oxidoreductase activity" EXACT [EC:1.14.18.1]
synonym: "monophenolase activity" EXACT [EC:1.14.18.1]
synonym: "N-acetyl-6-hydroxytryptophan oxidase activity" EXACT [EC:1.14.18.1]
synonym: "o-diphenol oxidase activity" RELATED [EC:1.14.18.1]
synonym: "o-diphenol oxidoreductase" RELATED [EC:1.14.18.1]
synonym: "o-diphenol:O2 oxidoreductase activity" RELATED [EC:1.14.18.1]
synonym: "o-diphenol:oxygen oxidoreductase" RELATED [EC:1.14.18.1]
synonym: "phenol oxidase activity" BROAD []
synonym: "phenolase activity" BROAD [EC:1.14.18.1]
synonym: "polyaromatic oxidase activity" EXACT [EC:1.14.18.1]
synonym: "polyphenolase activity" EXACT [EC:1.14.18.1]
synonym: "prophenol oxidase activity" RELATED [GOC:sart]
synonym: "prophenoloxidase activity" RELATED []
synonym: "pyrocatechol oxidase" BROAD [EC:1.14.18.1]
synonym: "tyrosinase activity" EXACT [EC:1.14.18.1]
synonym: "tyrosine-dopa oxidase activity" EXACT [EC:1.14.18.1]
xref: EC:1.14.18.1
xref: MetaCyc:MONOPHENOL-MONOOXYGENASE-RXN
xref: RHEA:18120
is_a: GO:0016716 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0004504
name: peptidylglycine monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: peptidyl-glycine + ascorbate + O2 = peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O." [EC:1.14.17.3]
subset: gosubset_prok
synonym: "PAM activity" EXACT [EC:1.14.17.3]
synonym: "PAM-A" RELATED [EC:1.14.17.3]
synonym: "PAM-B" RELATED [EC:1.14.17.3]
synonym: "peptide alpha-amidating enzyme" RELATED [EC:1.14.17.3]
synonym: "peptide alpha-amide synthase activity" EXACT [EC:1.14.17.3]
synonym: "peptide-alpha-amide synthetase activity" EXACT [EC:1.14.17.3]
synonym: "peptidyl alpha-amidating enzyme activity" EXACT [EC:1.14.17.3]
synonym: "peptidylglycine 2-hydroxylase activity" EXACT []
synonym: "peptidylglycine alpha-amidating monooxygenase activity" EXACT [EC:1.14.17.3]
synonym: "peptidylglycine alpha-hydroxylase activity" EXACT [EC:1.14.17.3]
synonym: "peptidylglycine,ascorbate:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.17.3]
synonym: "synthase, peptide alpha-amide" EXACT [EC:1.14.17.3]
xref: EC:1.14.17.3
xref: MetaCyc:PEPTIDYLGLYCINE-MONOOXYGENASE-RXN
is_a: GO:0016715 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0004505
name: phenylalanine 4-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4-alpha-hydroxytetrahydrobiopterin." [EC:1.14.16.1]
subset: gosubset_prok
synonym: "L-phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)" EXACT [EC:1.14.16.1]
synonym: "PAH activity" EXACT [EC:1.14.16.1]
synonym: "phenylalaninase activity" EXACT [EC:1.14.16.1]
synonym: "phenylalanine 4-hydroxylase activity" EXACT [EC:1.14.16.1]
synonym: "phenylalanine hydroxylase activity" EXACT []
xref: EC:1.14.16.1
xref: MetaCyc:PHENYLALANINE-4-MONOOXYGENASE-RXN
xref: Reactome:REACT_104236 "phenylalanine + tetrahydrobiopterin + O2 => tyrosine + 4a-hydroxytetrahydrobiopterin + H2O, Rattus norvegicus"
xref: Reactome:REACT_107202 "phenylalanine + tetrahydrobiopterin + O2 => tyrosine + 4a-hydroxytetrahydrobiopterin + H2O, Gallus gallus"
xref: Reactome:REACT_2 "phenylalanine + tetrahydrobiopterin + O2 => tyrosine + 4a-hydroxytetrahydrobiopterin + H2O, Homo sapiens"
xref: Reactome:REACT_32661 "phenylalanine + tetrahydrobiopterin + O2 => tyrosine + 4a-hydroxytetrahydrobiopterin + H2O, Canis familiaris"
xref: Reactome:REACT_33652 "phenylalanine + tetrahydrobiopterin + O2 => tyrosine + 4a-hydroxytetrahydrobiopterin + H2O, Drosophila melanogaster"
xref: Reactome:REACT_78419 "phenylalanine + tetrahydrobiopterin + O2 => tyrosine + 4a-hydroxytetrahydrobiopterin + H2O, Caenorhabditis elegans"
xref: Reactome:REACT_82050 "phenylalanine + tetrahydrobiopterin + O2 => tyrosine + 4a-hydroxytetrahydrobiopterin + H2O, Mus musculus"
xref: Reactome:REACT_89849 "phenylalanine + tetrahydrobiopterin + O2 => tyrosine + 4a-hydroxytetrahydrobiopterin + H2O, Bos taurus"
xref: Reactome:REACT_90357 "phenylalanine + tetrahydrobiopterin + O2 => tyrosine + 4a-hydroxytetrahydrobiopterin + H2O, Dictyostelium discoideum"
xref: Reactome:REACT_96148 "phenylalanine + tetrahydrobiopterin + O2 => tyrosine + 4a-hydroxytetrahydrobiopterin + H2O, Sus scrofa"
xref: Reactome:REACT_96746 "phenylalanine + tetrahydrobiopterin + O2 => tyrosine + 4a-hydroxytetrahydrobiopterin + H2O, Taeniopygia guttata"
xref: Reactome:REACT_99314 "phenylalanine + tetrahydrobiopterin + O2 => tyrosine + 4a-hydroxytetrahydrobiopterin + H2O, Danio rerio"
xref: Reactome:REACT_99414 "phenylalanine + tetrahydrobiopterin + O2 => tyrosine + 4a-hydroxytetrahydrobiopterin + H2O, Xenopus tropicalis"
xref: RHEA:20276
is_a: GO:0016714 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0004506
name: squalene monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(+) + NADPH + O(2) + squalene = (S)-2,3-epoxysqualene + H(2)O + NADP(+)." [RHEA:25285]
synonym: "squalene 2,3-oxidocyclase activity" EXACT [EC:1.14.13.132]
synonym: "squalene epoxidase activity" EXACT [EC:1.14.13.132]
synonym: "squalene hydroxylase activity" EXACT [EC:1.14.13.132]
synonym: "squalene oxydocyclase activity" EXACT [EC:1.14.13.132]
synonym: "squalene,NADPH:oxygen oxidoreductase (2,3-epoxidizing) activity" EXACT [KEGG:R02874]
synonym: "squalene-2,3-epoxidase activity" EXACT [EC:1.14.13.132]
synonym: "squalene-2,3-epoxide cyclase activity" EXACT [EC:1.14.13.132]
xref: EC:1.14.13.132
xref: KEGG:R02874
xref: MetaCyc:SQUALENE-MONOOXYGENASE-RXN
xref: Reactome:REACT_100198 "Squalene is oxidized to its epoxide, Xenopus tropicalis"
xref: Reactome:REACT_103513 "Squalene is oxidized to its epoxide, Oryza sativa"
xref: Reactome:REACT_31775 "Squalene is oxidized to its epoxide, Saccharomyces cerevisiae"
xref: Reactome:REACT_32861 "Squalene is oxidized to its epoxide, Dictyostelium discoideum"
xref: Reactome:REACT_34517 "Squalene is oxidized to its epoxide, Canis familiaris"
xref: Reactome:REACT_61044 "Squalene is oxidized to its epoxide, Schizosaccharomyces pombe"
xref: Reactome:REACT_77573 "Squalene is oxidized to its epoxide, Arabidopsis thaliana"
xref: Reactome:REACT_80341 "Squalene is oxidized to its epoxide, Sus scrofa"
xref: Reactome:REACT_80464 "Squalene is oxidized to its epoxide, Danio rerio"
xref: Reactome:REACT_80663 "Squalene is oxidized to its epoxide, Bos taurus"
xref: Reactome:REACT_90369 "Squalene is oxidized to its epoxide, Taeniopygia guttata"
xref: Reactome:REACT_93218 "Squalene is oxidized to its epoxide, Gallus gallus"
xref: Reactome:REACT_9420 "Squalene is oxidized to its epoxide, Homo sapiens"
xref: Reactome:REACT_96471 "Squalene is oxidized to its epoxide, Mus musculus"
xref: Reactome:REACT_99719 "Squalene is oxidized to its epoxide, Rattus norvegicus"
xref: RHEA:25285
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0004507
name: steroid 11-beta-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a steroid + reduced adrenal ferredoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O." [EC:1.14.15.4]
synonym: "cytochrome P450 CYP11B1" NARROW []
synonym: "cytochrome P450 CYP11B2" NARROW []
synonym: "cytochrome p450 XIB1 activity" NARROW [EC:1.14.15.4]
synonym: "oxygenase, steroid 11beta -mono-" EXACT [EC:1.14.15.4]
synonym: "steroid 11-beta-hydroxylase activity" EXACT []
synonym: "steroid 11-beta/18-hydroxylase activity" EXACT [EC:1.14.15.4]
synonym: "steroid 11beta-hydroxylase activity" EXACT [EC:1.14.15.4]
synonym: "steroid 11beta-monooxygenase activity" EXACT [EC:1.14.15.4]
synonym: "steroid 11beta/18-hydroxylase activity" EXACT [EC:1.14.15.4]
synonym: "steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11beta-hydroxylating)" EXACT [EC:1.14.15.4]
xref: EC:1.14.15.4
xref: MetaCyc:STEROID-11-BETA-MONOOXYGENASE-RXN
xref: Reactome:REACT_10037 "11-deoxycortisol is oxidised to cortisol by CYP11B1, Homo sapiens"
xref: Reactome:REACT_100776 "11-deoxycortisol is oxidised to cortisol by CYP11B1, Canis familiaris"
xref: Reactome:REACT_10117 "Hydroxylation of 11-deoxycorticosterone to form corticosterone, Homo sapiens"
xref: Reactome:REACT_102518 "11-deoxycortisol is oxidised to cortisol by CYP11B1, Bos taurus"
xref: Reactome:REACT_104959 "Hydroxylation of 11-deoxycorticosterone to form corticosterone, Danio rerio"
xref: Reactome:REACT_109791 "Hydroxylation of 11-deoxycorticosterone to form corticosterone, Drosophila melanogaster"
xref: Reactome:REACT_13700 "11-deoxycorticosterone is oxidised to corticosterone by CYP11B2, Homo sapiens"
xref: Reactome:REACT_32819 "Hydroxylation of 11-deoxycorticosterone to form corticosterone, Bos taurus"
xref: Reactome:REACT_33302 "Hydroxylation of 11-deoxycorticosterone to form corticosterone, Canis familiaris"
xref: Reactome:REACT_78151 "Hydroxylation of 11-deoxycorticosterone to form corticosterone, Mus musculus"
xref: Reactome:REACT_89955 "11-deoxycortisol is oxidised to cortisol by CYP11B1, Mus musculus"
xref: Reactome:REACT_93332 "11-deoxycortisol is oxidised to cortisol by CYP11B1, Drosophila melanogaster"
xref: Reactome:REACT_96419 "11-deoxycortisol is oxidised to cortisol by CYP11B1, Danio rerio"
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0004508
name: steroid 17-alpha-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O." [EC:1.14.99.9]
synonym: "17alpha-hydroxylase-C17,20 lyase activity" EXACT [EC:1.14.99.9]
synonym: "cytochrome P-450 (P-45017alpha,lyase)" RELATED [EC:1.14.99.9]
synonym: "cytochrome P450 CYP17" NARROW []
synonym: "cytochrome p450 XVIIA1 activity" NARROW [EC:1.14.99.9]
synonym: "cytochrome P45017alpha" RELATED [EC:1.14.99.9]
synonym: "steroid 17-alpha-hydroxylase activity" EXACT []
synonym: "steroid 17-alpha-hydroxylase-C17-20 lyase activity" EXACT []
synonym: "steroid 17-alpha-hydroxylase/17,20 lyase activity" EXACT [EC:1.14.99.9]
synonym: "steroid 17alpha-hydroxylase activity" EXACT [EC:1.14.99.9]
synonym: "steroid 17alpha-monooxygenase activity" EXACT [EC:1.14.99.9]
synonym: "steroid 17alphahydroxylase/17,20 lyase activity" EXACT [EC:1.14.99.9]
synonym: "steroid,hydrogen-donor:oxygen oxidoreductase (17alpha-hydroxylating)" EXACT [EC:1.14.99.9]
xref: EC:1.14.99.9
xref: MetaCyc:STEROID-17-ALPHA-MONOOXYGENASE-RXN
xref: Reactome:REACT_10013 "Side chain cleavage of 17alpha-hydroxyprogesterone to form 4-Androstene-3, 17-dione, Homo sapiens"
xref: Reactome:REACT_10026 "Side chain cleavage of 17alpha-hydroxypregnenolone to yield DHA, Homo sapiens"
xref: Reactome:REACT_100552 "Hydroxylation of pregnenolone to form 17alpha-hydroxypregnenolone, Mus musculus"
xref: Reactome:REACT_10116 "Hydroxylation of progesterone to form 17alpha-hydroxyprogesterone, Homo sapiens"
xref: Reactome:REACT_101338 "Side chain cleavage of 17alpha-hydroxypregnenolone to yield DHA, Danio rerio"
xref: Reactome:REACT_102153 "Side chain cleavage of 17alpha-hydroxyprogesterone to form 4-Androstene-3, 17-dione, Taeniopygia guttata"
xref: Reactome:REACT_103760 "Side chain cleavage of 17alpha-hydroxypregnenolone to yield DHA, Bos taurus"
xref: Reactome:REACT_112434 "Side chain cleavage of 17alpha-hydroxyprogesterone to form 4-Androstene-3, 17-dione, Gallus gallus"
xref: Reactome:REACT_113135 "Side chain cleavage of 17alpha-hydroxypregnenolone to yield DHA, Gallus gallus"
xref: Reactome:REACT_113443 "Hydroxylation of progesterone to form 17alpha-hydroxyprogesterone, Gallus gallus"
xref: Reactome:REACT_114963 "Hydroxylation of pregnenolone to form 17alpha-hydroxypregnenolone, Gallus gallus"
xref: Reactome:REACT_28596 "Hydroxylation of pregnenolone to form 17alpha-hydroxypregnenolone, Rattus norvegicus"
xref: Reactome:REACT_29409 "Hydroxylation of pregnenolone to form 17alpha-hydroxypregnenolone, Danio rerio"
xref: Reactome:REACT_33249 "Side chain cleavage of 17alpha-hydroxyprogesterone to form 4-Androstene-3, 17-dione, Sus scrofa"
xref: Reactome:REACT_33293 "Side chain cleavage of 17alpha-hydroxypregnenolone to yield DHA, Xenopus tropicalis"
xref: Reactome:REACT_34716 "Side chain cleavage of 17alpha-hydroxypregnenolone to yield DHA, Taeniopygia guttata"
xref: Reactome:REACT_78029 "Side chain cleavage of 17alpha-hydroxyprogesterone to form 4-Androstene-3, 17-dione, Canis familiaris"
xref: Reactome:REACT_78073 "Side chain cleavage of 17alpha-hydroxyprogesterone to form 4-Androstene-3, 17-dione, Danio rerio"
xref: Reactome:REACT_78525 "Hydroxylation of progesterone to form 17alpha-hydroxyprogesterone, Danio rerio"
xref: Reactome:REACT_80011 "Side chain cleavage of 17alpha-hydroxyprogesterone to form 4-Androstene-3, 17-dione, Mus musculus"
xref: Reactome:REACT_80170 "Hydroxylation of progesterone to form 17alpha-hydroxyprogesterone, Bos taurus"
xref: Reactome:REACT_80368 "Hydroxylation of pregnenolone to form 17alpha-hydroxypregnenolone, Xenopus tropicalis"
xref: Reactome:REACT_80594 "Side chain cleavage of 17alpha-hydroxypregnenolone to yield DHA, Canis familiaris"
xref: Reactome:REACT_81577 "Hydroxylation of progesterone to form 17alpha-hydroxyprogesterone, Rattus norvegicus"
xref: Reactome:REACT_82145 "Hydroxylation of progesterone to form 17alpha-hydroxyprogesterone, Sus scrofa"
xref: Reactome:REACT_82553 "Side chain cleavage of 17alpha-hydroxypregnenolone to yield DHA, Mus musculus"
xref: Reactome:REACT_82875 "Side chain cleavage of 17alpha-hydroxypregnenolone to yield DHA, Sus scrofa"
xref: Reactome:REACT_83833 "Hydroxylation of progesterone to form 17alpha-hydroxyprogesterone, Mus musculus"
xref: Reactome:REACT_85094 "Side chain cleavage of 17alpha-hydroxyprogesterone to form 4-Androstene-3, 17-dione, Xenopus tropicalis"
xref: Reactome:REACT_85131 "Hydroxylation of pregnenolone to form 17alpha-hydroxypregnenolone, Taeniopygia guttata"
xref: Reactome:REACT_85525 "Hydroxylation of pregnenolone to form 17alpha-hydroxypregnenolone, Sus scrofa"
xref: Reactome:REACT_85752 "Hydroxylation of progesterone to form 17alpha-hydroxyprogesterone, Canis familiaris"
xref: Reactome:REACT_88873 "Hydroxylation of pregnenolone to form 17alpha-hydroxypregnenolone, Canis familiaris"
xref: Reactome:REACT_90551 "Side chain cleavage of 17alpha-hydroxypregnenolone to yield DHA, Rattus norvegicus"
xref: Reactome:REACT_90696 "Side chain cleavage of 17alpha-hydroxyprogesterone to form 4-Androstene-3, 17-dione, Bos taurus"
xref: Reactome:REACT_95449 "Hydroxylation of progesterone to form 17alpha-hydroxyprogesterone, Taeniopygia guttata"
xref: Reactome:REACT_95861 "Hydroxylation of progesterone to form 17alpha-hydroxyprogesterone, Xenopus tropicalis"
xref: Reactome:REACT_98312 "Side chain cleavage of 17alpha-hydroxyprogesterone to form 4-Androstene-3, 17-dione, Rattus norvegicus"
xref: Reactome:REACT_98314 "Hydroxylation of pregnenolone to form 17alpha-hydroxypregnenolone, Bos taurus"
xref: Reactome:REACT_9993 "Hydroxylation of pregnenolone to form 17alpha-hydroxypregnenolone, Homo sapiens"
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0004509
name: steroid 21-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a steroid + donor-H2 + O2 = a 21-hydroxysteroid + acceptor + H2O." [EC:1.14.99.10]
synonym: "21-hydroxylase activity" EXACT [EC:1.14.99.10]
synonym: "cytochrome P450 CYP21A1" NARROW []
synonym: "cytochrome p450 XXIA1 activity" NARROW [EC:1.14.99.10]
synonym: "steroid 21-hydroxylase activity" EXACT []
synonym: "steroid,hydrogen-donor:oxygen oxidoreductase (21-hydroxylating)" EXACT [EC:1.14.99.10]
xref: EC:1.14.99.10
xref: MetaCyc:STEROID-21-MONOOXYGENASE-RXN
xref: Reactome:REACT_10032 "21-hydroxylation of progesterone to form 11-deoxycorticosterone, Homo sapiens"
xref: Reactome:REACT_9996 "Hydroxylation of 17-hydroxyprogesterone to form 11-deoxycortisol, Homo sapiens"
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0004510
name: tryptophan 5-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4-alpha-hydroxytetrahydrobiopterin + H2O." [EC:1.14.16.4]
synonym: "indoleacetic acid-5-hydroxylase activity" EXACT [EC:1.14.16.4]
synonym: "L-tryptophan hydroxylase activity" EXACT []
synonym: "L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)" EXACT [EC:1.14.16.4]
synonym: "tryptophan 5-hydroxylase activity" EXACT [EC:1.14.16.4]
synonym: "tryptophan hydroxylase activity" EXACT [EC:1.14.16.4]
xref: EC:1.14.16.4
xref: MetaCyc:TRYPTOPHAN-5-MONOOXYGENASE-RXN
xref: Reactome:REACT_100975 "Tryptophan is hydroxylated, Taeniopygia guttata"
xref: Reactome:REACT_104965 "Tryptophan is hydroxylated, Xenopus tropicalis"
xref: Reactome:REACT_105680 "Tryptophan is hydroxylated, Bos taurus"
xref: Reactome:REACT_106890 "Tryptophan is hydroxylated, Gallus gallus"
xref: Reactome:REACT_110501 "Tryptophan is hydroxylated, Sus scrofa"
xref: Reactome:REACT_112261 "Tryptophan is hydroxylated, Dictyostelium discoideum"
xref: Reactome:REACT_15352 "Tryptophan is hydroxylated, Homo sapiens"
xref: Reactome:REACT_29220 "Tryptophan is hydroxylated, Mus musculus"
xref: Reactome:REACT_29619 "Tryptophan is hydroxylated, Rattus norvegicus"
xref: Reactome:REACT_34802 "Tryptophan is hydroxylated, Caenorhabditis elegans"
xref: Reactome:REACT_81276 "Tryptophan is hydroxylated, Danio rerio"
xref: Reactome:REACT_89753 "Tryptophan is hydroxylated, Drosophila melanogaster"
xref: Reactome:REACT_99397 "Tryptophan is hydroxylated, Canis familiaris"
xref: RHEA:16712
is_a: GO:0016714 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0004511
name: tyrosine 3-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4-alpha-hydroxytetrahydrobiopterin + H2O." [EC:1.14.16.2]
synonym: "L-tyrosine hydroxylase activity" EXACT [EC:1.14.16.2]
synonym: "L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.16.2]
synonym: "tyrosine 3-hydroxylase activity" EXACT []
synonym: "tyrosine hydroxylase activity" EXACT []
xref: EC:1.14.16.2
xref: MetaCyc:TYROSINE-3-MONOOXYGENASE-RXN
xref: Reactome:REACT_100148 "Tyrosine is hydroxylated to dopa, Danio rerio"
xref: Reactome:REACT_100386 "Tyrosine is hydroxylated to dopa, Gallus gallus"
xref: Reactome:REACT_109224 "Tyrosine is hydroxylated to dopa, Taeniopygia guttata"
xref: Reactome:REACT_110490 "Tyrosine is hydroxylated to dopa, Drosophila melanogaster"
xref: Reactome:REACT_114697 "Tyrosine is hydroxylated to dopa, Dictyostelium discoideum"
xref: Reactome:REACT_15366 "Tyrosine is hydroxylated to dopa, Homo sapiens"
xref: Reactome:REACT_30893 "Tyrosine is hydroxylated to dopa, Rattus norvegicus"
xref: Reactome:REACT_31782 "Tyrosine is hydroxylated to dopa, Canis familiaris"
xref: Reactome:REACT_86771 "Tyrosine is hydroxylated to dopa, Mus musculus"
xref: Reactome:REACT_92333 "Tyrosine is hydroxylated to dopa, Bos taurus"
xref: Reactome:REACT_93744 "Tyrosine is hydroxylated to dopa, Caenorhabditis elegans"
xref: Reactome:REACT_98531 "Tyrosine is hydroxylated to dopa, Xenopus tropicalis"
xref: RHEA:18204
is_a: GO:0016714 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0004512
name: inositol-3-phosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate. This reaction requires NAD, which dehydrogenates the CHOH group to CO at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the aldehyde at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the CHOH form." [EC:5.5.1.4, RHEA:10719]
subset: gosubset_prok
synonym: "1L-myo-inositol-1-phosphate lyase (isomerizing)" EXACT [EC:5.5.1.4]
synonym: "D-glucose 6-phosphate cycloaldolase activity" EXACT [EC:5.5.1.4]
synonym: "glucocycloaldolase activity" EXACT [EC:5.5.1.4]
synonym: "glucose 6-phosphate cyclase activity" EXACT [EC:5.5.1.4]
synonym: "glucose-6-phosphate inositol monophosphate cycloaldolase activity" EXACT [EC:5.5.1.4]
synonym: "inositol 1-phosphate synthatase activity" EXACT [EC:5.5.1.4]
synonym: "inositol 1-phosphate synthetase activity" EXACT [EC:5.5.1.4]
xref: EC:5.5.1.4
xref: KEGG:R07324
xref: MetaCyc:MYO-INOSITOL-1-PHOSPHATE-SYNTHASE-RXN
xref: Reactome:REACT_27308 "glucose-6-phosphate is converted to inositol-1-phosphate, Mycobacterium tuberculosis"
xref: RHEA:10719
is_a: GO:0016872 ! intramolecular lyase activity

[Term]
id: GO:0004513
name: neolactotetraosylceramide alpha-2,3-sialyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-D-glucosylceramide." [EC:2.4.99.10]
synonym: "CMP-N-acetylneuraminate:neolactotetraosylceramide alpha-2,3-sialyltransferase activity" EXACT [EC:2.4.99.10]
synonym: "cytidine monophosphoacetylneuraminate-neolactotetraosylceramide sialyltransferase activity" EXACT [EC:2.4.99.10]
synonym: "SAT-3" RELATED [EC:2.4.99.10]
synonym: "sialyltransferase 3" RELATED [EC:2.4.99.10]
xref: EC:2.4.99.10
xref: MetaCyc:2.4.99.10-RXN
is_a: GO:0008373 ! sialyltransferase activity

[Term]
id: GO:0004514
name: nicotinate-nucleotide diphosphorylase (carboxylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: CO(2) + diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate." [EC:2.4.2.19, RHEA:12736]
subset: gosubset_prok
synonym: "NAD pyrophosphorylase activity" EXACT [EC:2.4.2.19]
synonym: "nicotinate mononucleotide pyrophosphorylase (carboxylating)" EXACT [EC:2.4.2.19]
synonym: "nicotinate-nucleotide pyrophosphorylase (carboxylating) activity" EXACT []
synonym: "nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase (carboxylating)" EXACT [EC:2.4.2.19]
synonym: "QAPRTase activity" EXACT [EC:2.4.2.19]
synonym: "quinolinate phosphoribosyltransferase (decarboxylating) activity" EXACT [EC:2.4.2.19]
synonym: "quinolinic acid phosphoribosyltransferase activity" EXACT [EC:2.4.2.19]
synonym: "quinolinic phosphoribosyltransferase activity" EXACT [EC:2.4.2.19]
xref: EC:2.4.2.19
xref: KEGG:R03348
xref: MetaCyc:QUINOPRIBOTRANS-RXN
xref: Reactome:REACT_103381 "A phospho-ribosyl group is added to quinolinate, Mus musculus"
xref: Reactome:REACT_105632 "A phospho-ribosyl group is added to quinolinate, Dictyostelium discoideum"
xref: Reactome:REACT_11092 "A phospho-ribosyl group is added to quinolinate, Homo sapiens"
xref: Reactome:REACT_28295 "A phospho-ribosyl group is added to quinolinate, Bos taurus"
xref: Reactome:REACT_29883 "A phospho-ribosyl group is added to quinolinate, Rattus norvegicus"
xref: Reactome:REACT_31306 "A phospho-ribosyl group is added to quinolinate, Mycobacterium tuberculosis"
xref: Reactome:REACT_85574 "A phospho-ribosyl group is added to quinolinate, Xenopus tropicalis"
xref: Reactome:REACT_86011 "A phospho-ribosyl group is added to quinolinate, Oryza sativa"
xref: Reactome:REACT_90651 "A phospho-ribosyl group is added to quinolinate, Arabidopsis thaliana"
xref: Reactome:REACT_90824 "A phospho-ribosyl group is added to quinolinate, Taeniopygia guttata"
xref: Reactome:REACT_90894 "A phospho-ribosyl group is added to quinolinate, Saccharomyces cerevisiae"
xref: Reactome:REACT_91005 "A phospho-ribosyl group is added to quinolinate, Canis familiaris"
xref: Reactome:REACT_91028 "A phospho-ribosyl group is added to quinolinate, Escherichia coli"
xref: RHEA:12736
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0004515
name: nicotinate-nucleotide adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+." [EC:2.7.7.18]
subset: gosubset_prok
synonym: "ATP:nicotinate-nucleotide adenylyltransferase activity" EXACT []
synonym: "ATP:nicotinate-ribonucleotide adenylyltransferase activity" EXACT [EC:2.7.7.18]
synonym: "deamido-NAD(+) diphosphorylase activity" EXACT [EC:2.7.7.18]
synonym: "deamido-NAD(+) pyrophosphorylase activity" EXACT [EC:2.7.7.18]
synonym: "deamido-NAD+ pyrophosphorylase activity" EXACT [EC:2.7.7.18]
synonym: "deamidonicotinamide adenine dinucleotide pyrophosphorylase activity" EXACT [EC:2.7.7.18]
synonym: "NaMN-ATase activity" EXACT [EC:2.7.7.18]
synonym: "nicotinate mononucleotide adenylyltransferase activity" EXACT [EC:2.7.7.18]
synonym: "nicotinic acid mononucleotide adenylyltransferase" NARROW []
xref: EC:2.7.7.18
xref: MetaCyc:NICONUCADENYLYLTRAN-RXN
xref: RHEA:22863
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0004516
name: nicotinate phosphoribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinate." [EC:2.4.2.11, RHEA:13396]
subset: gosubset_prok
synonym: "niacin ribonucleotidase activity" EXACT [EC:2.4.2.11]
synonym: "nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.11]
synonym: "nicotinic acid mononucleotide glycohydrolase activity" EXACT [EC:2.4.2.11]
synonym: "nicotinic acid mononucleotide pyrophosphorylase activity" EXACT [EC:2.4.2.11]
synonym: "nicotinic acid phosphoribosyltransferase activity" EXACT [EC:2.4.2.11]
xref: EC:2.4.2.11
xref: KEGG:R01724
xref: MetaCyc:NICOTINATEPRIBOSYLTRANS-RXN
xref: Reactome:REACT_102849 "A phosphoribosyl group is added to nicotinate to form nicotinate mononucleotide (NaMN), Bos taurus"
xref: Reactome:REACT_107445 "A phosphoribosyl group is added to nicotinate to form nicotinate mononucleotide (NaMN), Oryza sativa"
xref: Reactome:REACT_11132 "A phosphoribosyl group is added to nicotinate to form nicotinate mononucleotide (NaMN), Homo sapiens"
xref: Reactome:REACT_30177 "A phosphoribosyl group is added to nicotinate to form nicotinate mononucleotide (NaMN), Plasmodium falciparum"
xref: Reactome:REACT_33592 "A phosphoribosyl group is added to nicotinate to form nicotinate mononucleotide (NaMN), Arabidopsis thaliana"
xref: Reactome:REACT_78679 "A phosphoribosyl group is added to nicotinate to form nicotinate mononucleotide (NaMN), Rattus norvegicus"
xref: Reactome:REACT_79312 "A phosphoribosyl group is added to nicotinate to form nicotinate mononucleotide (NaMN), Staphylococcus aureus N315"
xref: Reactome:REACT_79471 "A phosphoribosyl group is added to nicotinate to form nicotinate mononucleotide (NaMN), Caenorhabditis elegans"
xref: Reactome:REACT_79952 "A phosphoribosyl group is added to nicotinate to form nicotinate mononucleotide (NaMN), Danio rerio"
xref: Reactome:REACT_82193 "A phosphoribosyl group is added to nicotinate to form nicotinate mononucleotide (NaMN), Mycobacterium tuberculosis"
xref: Reactome:REACT_82687 "A phosphoribosyl group is added to nicotinate to form nicotinate mononucleotide (NaMN), Dictyostelium discoideum"
xref: Reactome:REACT_83088 "A phosphoribosyl group is added to nicotinate to form nicotinate mononucleotide (NaMN), Drosophila melanogaster"
xref: Reactome:REACT_92507 "A phosphoribosyl group is added to nicotinate to form nicotinate mononucleotide (NaMN), Gallus gallus"
xref: Reactome:REACT_93007 "A phosphoribosyl group is added to nicotinate to form nicotinate mononucleotide (NaMN), Mus musculus"
xref: Reactome:REACT_93585 "A phosphoribosyl group is added to nicotinate to form nicotinate mononucleotide (NaMN), Xenopus tropicalis"
xref: Reactome:REACT_96814 "A phosphoribosyl group is added to nicotinate to form nicotinate mononucleotide (NaMN), Taeniopygia guttata"
xref: RHEA:13396
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0004517
name: nitric-oxide synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+." [EC:1.14.13.39]
subset: gosubset_prok
synonym: "endothelium-derived relaxation factor-forming enzyme activity" RELATED [EC:1.14.13.39]
synonym: "endothelium-derived relaxing factor synthase activity" RELATED [EC:1.14.13.39]
synonym: "L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) activity" EXACT [EC:1.14.13.39]
synonym: "NADPH-diaphorase activity" EXACT [EC:1.14.13.39]
synonym: "nitric oxide synthase activity" EXACT []
synonym: "nitric oxide synthetase activity" EXACT [EC:1.14.13.39]
synonym: "nitric-oxide synthetase activity" EXACT [EC:1.14.13.39]
synonym: "NO synthase activity" EXACT [EC:1.14.13.39]
xref: EC:1.14.13.39
xref: MetaCyc:NITRIC-OXIDE-SYNTHASE-RXN
xref: Reactome:REACT_100132 "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO), Rattus norvegicus"
xref: Reactome:REACT_105423 "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO), Canis familiaris"
xref: Reactome:REACT_113518 "NO biosynthesis, Taeniopygia guttata"
xref: Reactome:REACT_12443 "NO biosynthesis, Homo sapiens"
xref: Reactome:REACT_23872 "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO), Homo sapiens"
xref: Reactome:REACT_29232 "NO biosynthesis, Rattus norvegicus"
xref: Reactome:REACT_30996 "NO biosynthesis, Sus scrofa"
xref: Reactome:REACT_77300 "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO), Xenopus tropicalis"
xref: Reactome:REACT_77934 "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO), Gallus gallus"
xref: Reactome:REACT_80256 "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO), Bos taurus"
xref: Reactome:REACT_84552 "NO biosynthesis, Mus musculus"
xref: Reactome:REACT_85890 "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO), Mus musculus"
xref: Reactome:REACT_86754 "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO), Taeniopygia guttata"
xref: Reactome:REACT_88372 "NO biosynthesis, Canis familiaris"
xref: Reactome:REACT_90393 "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO), Danio rerio"
xref: Reactome:REACT_91384 "NO biosynthesis, Bos taurus"
xref: Reactome:REACT_94267 "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO), Sus scrofa"
xref: Reactome:REACT_99750 "NO biosynthesis, Xenopus tropicalis"
xref: RHEA:24668
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0004518
name: nuclease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]
comment: Note that 'tRNA nucleotidyltransferase activity ; GO:0009022', also known as 'ribonuclease PH', does not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis.
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
xref: EC:3.1.-.-
is_a: GO:0016788 ! hydrolase activity, acting on ester bonds
relationship: part_of GO:0090305 ! nucleic acid phosphodiester bond hydrolysis

[Term]
id: GO:0004519
name: endonuclease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
subset: gosubset_prok
xref: Reactome:REACT_100654 "3'- incision of DNA by XPG in GG-NER, Arabidopsis thaliana"
xref: Reactome:REACT_101397 "3'- incision of DNA by XPG in GG-NER, Danio rerio"
xref: Reactome:REACT_103600 "3'- incision of DNA by XPG in GG-NER, Gallus gallus"
xref: Reactome:REACT_106502 "3'- incision of DNA by XPG in GG-NER, Rattus norvegicus"
xref: Reactome:REACT_108614 "3'- incision of DNA by XPG in GG-NER, Taeniopygia guttata"
xref: Reactome:REACT_110731 "3'- incision of DNA by XPG in GG-NER, Xenopus tropicalis"
xref: Reactome:REACT_112366 "Removal of 3'-phosphoglycolate (PG) moiety from DSB ends, Danio rerio"
xref: Reactome:REACT_1124 "3'- incision of DNA by XPG in GG-NER, Homo sapiens"
xref: Reactome:REACT_112509 "Cleavage of mRNA at the 3'-end, Arabidopsis thaliana"
xref: Reactome:REACT_112615 "Removal of 3'-phosphoglycolate (PG) moiety from DSB ends, Rattus norvegicus"
xref: Reactome:REACT_112782 "Removal of 3'-phosphoglycolate (PG) moiety from DSB ends, Xenopus tropicalis"
xref: Reactome:REACT_113127 "Removal of 3'-phosphoglycolate (PG) moiety from DSB ends, Taeniopygia guttata"
xref: Reactome:REACT_113480 "Removal of 3'-phosphoglycolate (PG) moiety from DSB ends, Gallus gallus"
xref: Reactome:REACT_113819 "Cleavage of mRNA at the 3'-end, Drosophila melanogaster"
xref: Reactome:REACT_114931 "Removal of 3'-phosphoglycolate (PG) moiety from DSB ends, Canis familiaris"
xref: Reactome:REACT_115221 "Removal of 3'-phosphoglycolate (PG) moiety from DSB ends, Mus musculus"
xref: Reactome:REACT_115226 "Removal of 3'-phosphoglycolate (PG) moiety from DSB ends, Bos taurus"
xref: Reactome:REACT_115382 "Removal of 3'-phosphoglycolate (PG) moiety from DSB ends, Sus scrofa"
xref: Reactome:REACT_115937 "Displacement of DNA glycosylase and endonucleolytic cleavage by DNA-lyase, Gallus gallus"
xref: Reactome:REACT_116011 "Removal of 3'-phosphoglycolate (PG) moiety from DSB ends, Gallus gallus"
xref: Reactome:REACT_1914 "Cleavage of mRNA at the 3'-end, Homo sapiens"
xref: Reactome:REACT_34610 "Cleavage of mRNA at the 3'-end, Bos taurus"
xref: Reactome:REACT_6746 "Removal of 3'-phosphate moiety from DSB ends, Homo sapiens"
xref: Reactome:REACT_6774 "Removal of 3'-phosphoglycolate (PG) moiety from DSB ends, Homo sapiens"
xref: Reactome:REACT_77706 "Cleavage of mRNA at the 3'-end, Taeniopygia guttata"
xref: Reactome:REACT_78624 "3'- incision of DNA by XPG in GG-NER, Canis familiaris"
xref: Reactome:REACT_79198 "Cleavage of mRNA at the 3'-end, Canis familiaris"
xref: Reactome:REACT_80387 "3'- incision of DNA by XPG in GG-NER, Caenorhabditis elegans"
xref: Reactome:REACT_80628 "3'- incision of DNA by XPG in GG-NER, Saccharomyces cerevisiae"
xref: Reactome:REACT_80681 "3'- incision of DNA by XPG in GG-NER, Bos taurus"
xref: Reactome:REACT_80797 "Cleavage of mRNA at the 3'-end, Mus musculus"
xref: Reactome:REACT_81714 "3'- incision of DNA by XPG in GG-NER, Oryza sativa"
xref: Reactome:REACT_87541 "Cleavage of mRNA at the 3'-end, Xenopus tropicalis"
xref: Reactome:REACT_89800 "3'- incision of DNA by XPG in GG-NER, Schizosaccharomyces pombe"
xref: Reactome:REACT_90034 "3'- incision of DNA by XPG in GG-NER, Mus musculus"
xref: Reactome:REACT_90935 "3'- incision of DNA by XPG in GG-NER, Sus scrofa"
xref: Reactome:REACT_92894 "3'- incision of DNA by XPG in GG-NER, Drosophila melanogaster"
is_a: GO:0004518 ! nuclease activity

[Term]
id: GO:0004520
name: endodeoxyribonuclease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684]
subset: gosubset_prok
synonym: "DNA nicking activity" RELATED [GOC:mah]
synonym: "endonuclease G activity" RELATED []
xref: Reactome:REACT_101184 "5'-incision of DNA by ERCC1-XPF in GG-NER, Danio rerio"
xref: Reactome:REACT_101250 "5' incision leading to excision of DNA fragment with lesion in TC-NER, Caenorhabditis elegans"
xref: Reactome:REACT_101987 "APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue, Dictyostelium discoideum"
xref: Reactome:REACT_103441 "APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue, Rattus norvegicus"
xref: Reactome:REACT_103771 "3' incision of the lesioned strand of DNA in TC-NER, Xenopus tropicalis"
xref: Reactome:REACT_104010 "APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue, Danio rerio"
xref: Reactome:REACT_104673 "5' incision leading to excision of DNA fragment with lesion in TC-NER, Schizosaccharomyces pombe"
xref: Reactome:REACT_104703 "APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue, Taeniopygia guttata"
xref: Reactome:REACT_104968 "APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue, Sus scrofa"
xref: Reactome:REACT_106756 "3' incision of the lesioned strand of DNA in TC-NER, Drosophila melanogaster"
xref: Reactome:REACT_109040 "3' incision of the lesioned strand of DNA in TC-NER, Canis familiaris"
xref: Reactome:REACT_109537 "APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue, Xenopus tropicalis"
xref: Reactome:REACT_109692 "3' incision of the lesioned strand of DNA in TC-NER, Sus scrofa"
xref: Reactome:REACT_110386 "3' incision of the lesioned strand of DNA in TC-NER, Danio rerio"
xref: Reactome:REACT_112122 "5'-incision of DNA by ERCC1-XPF in GG-NER, Xenopus tropicalis"
xref: Reactome:REACT_112152 "3' incision of the lesioned strand of DNA in TC-NER, Taeniopygia guttata"
xref: Reactome:REACT_115154 "5' incision leading to excision of DNA fragment with lesion in TC-NER, Gallus gallus"
xref: Reactome:REACT_115463 "5' incision leading to excision of DNA fragment with lesion in TC-NER, Taeniopygia guttata"
xref: Reactome:REACT_115479 "3' incision of the lesioned strand of DNA in TC-NER, Gallus gallus"
xref: Reactome:REACT_1274 "3' incision of the lesioned strand of DNA in TC-NER, Homo sapiens"
xref: Reactome:REACT_1311 "5'-incision of DNA by ERCC1-XPF in GG-NER, Homo sapiens"
xref: Reactome:REACT_1964 "APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue, Homo sapiens"
xref: Reactome:REACT_27164 "Removal of SPO11 and Resection of 5' Ends of DNA (yeast), Saccharomyces cerevisiae"
xref: Reactome:REACT_27209 "Removal of SPO11 and Resection of 5' Ends of DNA, Homo sapiens"
xref: Reactome:REACT_28610 "5' incision leading to excision of DNA fragment with lesion in TC-NER, Bos taurus"
xref: Reactome:REACT_28960 "3' incision of the lesioned strand of DNA in TC-NER, Rattus norvegicus"
xref: Reactome:REACT_30718 "3' incision of the lesioned strand of DNA in TC-NER, Dictyostelium discoideum"
xref: Reactome:REACT_31162 "5' incision leading to excision of DNA fragment with lesion in TC-NER, Arabidopsis thaliana"
xref: Reactome:REACT_31548 "APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue, Caenorhabditis elegans"
xref: Reactome:REACT_31660 "3' incision of the lesioned strand of DNA in TC-NER, Schizosaccharomyces pombe"
xref: Reactome:REACT_31823 "5' incision leading to excision of DNA fragment with lesion in TC-NER, Oryza sativa"
xref: Reactome:REACT_32833 "3' incision of the lesioned strand of DNA in TC-NER, Saccharomyces cerevisiae"
xref: Reactome:REACT_33043 "3' incision of the lesioned strand of DNA in TC-NER, Bos taurus"
xref: Reactome:REACT_78421 "5' incision leading to excision of DNA fragment with lesion in TC-NER, Sus scrofa"
xref: Reactome:REACT_79265 "5' incision leading to excision of DNA fragment with lesion in TC-NER, Dictyostelium discoideum"
xref: Reactome:REACT_80173 "APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue, Mus musculus"
xref: Reactome:REACT_80298 "3' incision of the lesioned strand of DNA in TC-NER, Caenorhabditis elegans"
xref: Reactome:REACT_80967 "3' incision of the lesioned strand of DNA in TC-NER, Oryza sativa"
xref: Reactome:REACT_811 "5' incision leading to excision of DNA fragment with lesion in TC-NER, Homo sapiens"
xref: Reactome:REACT_81197 "5' incision leading to excision of DNA fragment with lesion in TC-NER, Mus musculus"
xref: Reactome:REACT_82925 "5' incision leading to excision of DNA fragment with lesion in TC-NER, Canis familiaris"
xref: Reactome:REACT_83838 "5'-incision of DNA by ERCC1-XPF in GG-NER, Rattus norvegicus"
xref: Reactome:REACT_85019 "APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue, Drosophila melanogaster"
xref: Reactome:REACT_88339 "5' incision leading to excision of DNA fragment with lesion in TC-NER, Rattus norvegicus"
xref: Reactome:REACT_90087 "5' incision leading to excision of DNA fragment with lesion in TC-NER, Danio rerio"
xref: Reactome:REACT_92741 "3' incision of the lesioned strand of DNA in TC-NER, Arabidopsis thaliana"
xref: Reactome:REACT_94592 "5' incision leading to excision of DNA fragment with lesion in TC-NER, Drosophila melanogaster"
xref: Reactome:REACT_94820 "APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue, Canis familiaris"
xref: Reactome:REACT_95903 "5'-incision of DNA by ERCC1-XPF in GG-NER, Mus musculus"
xref: Reactome:REACT_97114 "5' incision leading to excision of DNA fragment with lesion in TC-NER, Xenopus tropicalis"
xref: Reactome:REACT_98405 "5' incision leading to excision of DNA fragment with lesion in TC-NER, Saccharomyces cerevisiae"
xref: Reactome:REACT_98417 "APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue, Bos taurus"
xref: Reactome:REACT_99783 "3' incision of the lesioned strand of DNA in TC-NER, Mus musculus"
is_a: GO:0004519 ! endonuclease activity
is_a: GO:0004536 ! deoxyribonuclease activity

[Term]
id: GO:0004521
name: endoribonuclease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684]
subset: gosubset_prok
synonym: "endonuclease G activity" RELATED []
xref: Reactome:REACT_22313 "Cleavage of Xbp1 mRNA by IRE1alpha and Splicing of Cleaved Xbp1 mRNA, Homo sapiens"
xref: Reactome:REACT_75787 "SMG6 Cleaves mRNA with Premature Termination Codon, Homo sapiens"
is_a: GO:0004519 ! endonuclease activity
is_a: GO:0004540 ! ribonuclease activity
relationship: part_of GO:0090502 ! RNA phosphodiester bond hydrolysis, endonucleolytic

[Term]
id: GO:0004522
name: ribonuclease A activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of RNA to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in C-P or U-P with 2',3'-cyclic phosphate intermediates." [EC:3.1.27.5]
synonym: "alkaline ribonuclease activity" EXACT [EC:3.1.27.5]
synonym: "ceratitis capitata alkaline ribonuclease activity" EXACT [EC:3.1.27.5]
synonym: "endoribonuclease I" RELATED [EC:3.1.27.5]
synonym: "gene S glycoproteins" RELATED [EC:3.1.27.5]
synonym: "gene S locus-specific glycoproteins" RELATED [EC:3.1.27.5]
synonym: "pancreatic ribonuclease activity" NARROW []
synonym: "pancreatic RNase activity" EXACT [EC:3.1.27.5]
synonym: "ribonuclease I activity" EXACT [EC:3.1.27.5]
synonym: "ribonucleate 3'-pyrimidino-oligonucleotidohydrolase activity" EXACT [EC:3.1.27.5]
synonym: "ribonucleic phosphatase activity" EXACT [EC:3.1.27.5]
synonym: "RNase A activity" EXACT [EC:3.1.27.5]
synonym: "RNase activity" BROAD [EC:3.1.27.5]
synonym: "RNase I activity" EXACT [EC:3.1.27.5]
synonym: "S-genotype-assocd. glycoproteins" RELATED [EC:3.1.27.5]
synonym: "SLSG glycoproteins" RELATED [EC:3.1.27.5]
xref: EC:3.1.27.5
xref: MetaCyc:3.1.27.5-RXN
xref: Wikipedia:Ribonuclease_A
is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters

[Term]
id: GO:0004523
name: RNA-DNA hybrid ribonuclease activity
namespace: molecular_function
alt_id: GO:0004524
def: "Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4]
comment: Note that the EC recommended name for this enzyme activity is 'calf thymus ribonuclease H', even though it is found in many species.
subset: gosubset_prok
synonym: "calf thymus ribonuclease H activity" EXACT []
synonym: "endoribonuclease H" RELATED [EC:3.1.26.4]
synonym: "endoribonuclease H (calf thymus)" RELATED [EC:3.1.26.4]
synonym: "endoribonuclease0 H activity" NARROW [EC:3.1.26.4]
synonym: "hybrid nuclease activity" EXACT [EC:3.1.26.4]
synonym: "hybrid ribonuclease activity" EXACT [EC:3.1.26.4]
synonym: "hybridase (ribonuclease H)" EXACT [EC:3.1.26.4]
synonym: "hybridase activity" EXACT [EC:3.1.26.4]
synonym: "ribonuclease H activity" EXACT [GOC:vw]
synonym: "ribonuclease H1 activity" NARROW []
synonym: "ribonuclease H2 activity" NARROW []
synonym: "ribonuclease H3 activity" NARROW []
synonym: "RNA*DNA hybrid ribonucleotidohydrolase activity" EXACT [EC:3.1.26.4]
synonym: "RNase H activity" EXACT []
synonym: "RNase H1 activity" NARROW []
synonym: "RNase H2 activity" NARROW []
synonym: "RNase H3 activity" NARROW []
xref: EC:3.1.26.4
xref: MetaCyc:3.1.26.4-RXN
xref: Reactome:REACT_8999 "RNase H-mediated digestion of tRNA, 3'PPT and cPPT RNA primers, Homo sapiens"
xref: Reactome:REACT_9014 "RNase H-mediated degradation of the RNA strand of the -sssDNA:RNA duplex, Homo sapiens"
xref: Reactome:REACT_9040 "RNase H-mediated cleavage of the template strand, Homo sapiens"
xref: Reactome:REACT_9046 "RNase H-mediated cleavage of the RNA strand of the -sssDNA:RNA duplex, Homo sapiens"
xref: Reactome:REACT_9066 "RNase H-mediated degradation of the template strand, Homo sapiens"
is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0004525
name: ribonuclease III activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt." [PMID:11157775, PMID:15242644]
subset: gosubset_prok
synonym: "pre-mRNA 3'-end processing endonuclease" NARROW []
synonym: "ribonuclease 3 activity" EXACT [EC:3.1.26.3]
synonym: "RNase III activity" EXACT [EC:3.1.26.3]
xref: EC:3.1.26.3
xref: MetaCyc:3.1.26.3-RXN
xref: Reactome:REACT_101646 "Microprocessor complex cleaves pri-miRNA to pre-miRNA, Canis familiaris"
xref: Reactome:REACT_103474 "Dicer cleaves pre-miRNA to yield mature miRNA, Xenopus tropicalis"
xref: Reactome:REACT_104119 "Dicer cleaves pre-miRNA to yield mature miRNA, Danio rerio"
xref: Reactome:REACT_106335 "Dicer cleaves pre-miRNA to yield mature miRNA, Taeniopygia guttata"
xref: Reactome:REACT_107961 "Microprocessor complex cleaves pri-miRNA to pre-miRNA, Mus musculus"
xref: Reactome:REACT_109221 "Microprocessor complex cleaves pri-miRNA to pre-miRNA, Danio rerio"
xref: Reactome:REACT_109630 "Microprocessor complex cleaves pri-miRNA to pre-miRNA, Taeniopygia guttata"
xref: Reactome:REACT_115273 "Dicer cleaves pre-miRNA to yield mature miRNA, Caenorhabditis elegans"
xref: Reactome:REACT_12414 "Microprocessor complex cleaves pri-miRNA to pre-miRNA, Homo sapiens"
xref: Reactome:REACT_12438 "Dicer cleaves pre-miRNA to yield mature miRNA, Homo sapiens"
xref: Reactome:REACT_33849 "Microprocessor complex cleaves pri-miRNA to pre-miRNA, Xenopus tropicalis"
xref: Reactome:REACT_77295 "Dicer cleaves pre-miRNA to yield mature miRNA, Drosophila melanogaster"
xref: Reactome:REACT_77311 "Microprocessor complex cleaves pri-miRNA to pre-miRNA, Rattus norvegicus"
xref: Reactome:REACT_77692 "Dicer cleaves pre-miRNA to yield mature miRNA, Canis familiaris"
xref: Reactome:REACT_78540 "Microprocessor complex cleaves pri-miRNA to pre-miRNA, Bos taurus"
xref: Reactome:REACT_79325 "Microprocessor complex cleaves pri-miRNA to pre-miRNA, Sus scrofa"
xref: Reactome:REACT_80484 "Microprocessor complex cleaves pri-miRNA to pre-miRNA, Drosophila melanogaster"
xref: Reactome:REACT_86280 "Microprocessor complex cleaves pri-miRNA to pre-miRNA, Gallus gallus"
xref: Reactome:REACT_90204 "Dicer cleaves pre-miRNA to yield mature miRNA, Rattus norvegicus"
xref: Reactome:REACT_91920 "Dicer cleaves pre-miRNA to yield mature miRNA, Mus musculus"
xref: Reactome:REACT_92676 "Microprocessor complex cleaves pri-miRNA to pre-miRNA, Caenorhabditis elegans"
xref: Reactome:REACT_95779 "Dicer cleaves pre-miRNA to yield mature miRNA, Bos taurus"
is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters
is_a: GO:0032296 ! double-stranded RNA-specific ribonuclease activity

[Term]
id: GO:0004526
name: ribonuclease P activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor." [EC:3.1.26.5]
subset: gosubset_prok
synonym: "RNase P" EXACT []
synonym: "tRNA 5' leader endonuclease activity" EXACT []
xref: EC:3.1.26.5
xref: MetaCyc:3.1.26.5-RXN
xref: Wikipedia:RNase_P
is_a: GO:0004549 ! tRNA-specific ribonuclease activity
is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0004527
name: exonuclease activity
namespace: molecular_function
alt_id: GO:0008857
def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684]
subset: gosubset_prok
synonym: "exonuclease IX activity" NARROW []
is_a: GO:0004518 ! nuclease activity

[Term]
id: GO:0004528
name: phosphodiesterase I activity
namespace: molecular_function
def: "Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides." [EC:3.1.4.1]
subset: gosubset_prok
synonym: "5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity" EXACT [EC:3.1.4.1]
synonym: "5'-exonuclease activity" RELATED [EC:3.1.4.1]
synonym: "5'-NPDase activity" RELATED [EC:3.1.4.1]
synonym: "5'-nucleotide phosphodiesterase activity" RELATED [EC:3.1.4.1]
synonym: "5'-PDase activity" RELATED [EC:3.1.4.1]
synonym: "5'-PDE activity" RELATED [EC:3.1.4.1]
synonym: "5'-phosphodiesterase activity" RELATED [EC:3.1.4.1]
synonym: "5'NPDE activity" RELATED [EC:3.1.4.1]
synonym: "alkaline phosphodiesterase activity" RELATED [EC:3.1.4.1]
synonym: "exonuclease I activity" RELATED [EC:3.1.4.1]
synonym: "nucleotide pyrophosphatase/phosphodiesterase I activity" EXACT [EC:3.1.4.1]
synonym: "oligonucleate 5'-nucleotidohydrolase activity" EXACT [EC:3.1.4.1]
synonym: "orthophosphoric diester phosphohydrolase activity" EXACT [EC:3.1.4.1]
synonym: "PDE I activity" EXACT [EC:3.1.4.1]
synonym: "phosphodiesterase activity" BROAD [EC:3.1.4.1]
xref: EC:3.1.4.1
xref: MetaCyc:3.1.4.1-RXN
is_a: GO:0004527 ! exonuclease activity
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0004529
name: exodeoxyribonuclease activity
namespace: molecular_function
def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule." [GOC:mah, ISBN:0198547684]
subset: gosubset_prok
is_a: GO:0004527 ! exonuclease activity
is_a: GO:0004536 ! deoxyribonuclease activity

[Term]
id: GO:0004530
name: deoxyribonuclease I activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of DNA to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end products." [EC:3.1.21.1]
subset: gosubset_prok
synonym: "alkaline deoxyribonuclease activity" EXACT [EC:3.1.21.1]
synonym: "alkaline DNase activity" EXACT [EC:3.1.21.1]
synonym: "deoxyribonuclease (pancreatic)" NARROW [EC:3.1.21.1]
synonym: "deoxyribonuclease A" RELATED [EC:3.1.21.1]
synonym: "deoxyribonucleic phosphatase activity" EXACT [EC:3.1.21.1]
synonym: "DNA depolymerase activity" EXACT [EC:3.1.21.1]
synonym: "DNA endonuclease activity" EXACT [EC:3.1.21.1]
synonym: "DNA nuclease activity" EXACT [EC:3.1.21.1]
synonym: "DNAase activity" EXACT [EC:3.1.21.1]
synonym: "DNase activity" NARROW [EC:3.1.21.1]
synonym: "DNase I" RELATED [EC:3.1.21.1]
synonym: "dornava" RELATED [EC:3.1.21.1]
synonym: "dornavac" RELATED [EC:3.1.21.1]
synonym: "endodeoxyribonuclease I" RELATED [EC:3.1.21.1]
synonym: "Escherichia coli endonuclease I" RELATED [EC:3.1.21.1]
synonym: "pancreatic deoxyribonuclease" NARROW [EC:3.1.21.1]
synonym: "pancreatic DNase activity" NARROW [EC:3.1.21.1]
synonym: "pancreatic dornase" NARROW [EC:3.1.21.1]
synonym: "thymonuclease activity" NARROW [EC:3.1.21.1]
synonym: "thymonuclease, dornase activity" EXACT [EC:3.1.21.1]
xref: EC:3.1.21.1
xref: MetaCyc:3.1.21.1-RXN
is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0004531
name: deoxyribonuclease II activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of DNA to 3'-phosphodinucleotide and 3'-phosphooligonucleotide end products." [EC:3.1.22.1]
subset: gosubset_prok
synonym: "acid deoxyribonuclease activity" EXACT [EC:3.1.22.1]
synonym: "acid DNase activity" EXACT [EC:3.1.22.1]
synonym: "deoxyribonucleate 3'-nucleotidohydrolase activity" EXACT [EC:3.1.22.1]
synonym: "DNase II activity" EXACT [EC:3.1.22.1]
synonym: "lysosomal DNase II activity" NARROW [EC:3.1.22.1]
synonym: "pancreatic DNase II" RELATED [EC:3.1.22.1]
xref: EC:3.1.22.1
xref: MetaCyc:3.1.22.1-RXN
is_a: GO:0016889 ! endodeoxyribonuclease activity, producing 3'-phosphomonoesters

[Term]
id: GO:0004532
name: exoribonuclease activity
namespace: molecular_function
def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684]
subset: gosubset_prok
xref: Reactome:REACT_109605 "Scavenging of the 7-methylguanosine Cap by DCPS, Sus scrofa"
xref: Reactome:REACT_109680 "Scavenging of the 7-methylguanosine Cap by DCPS, Rattus norvegicus"
xref: Reactome:REACT_20556 "Scavenging of the 7-methylguanosine Cap by DCPS, Homo sapiens"
xref: Reactome:REACT_29104 "Scavenging of the 7-methylguanosine Cap by DCPS, Danio rerio"
xref: Reactome:REACT_32104 "Scavenging of the 7-methylguanosine Cap by DCPS, Bos taurus"
xref: Reactome:REACT_78260 "Scavenging of the 7-methylguanosine Cap by DCPS, Xenopus tropicalis"
xref: Reactome:REACT_79364 "Scavenging of the 7-methylguanosine Cap by DCPS, Gallus gallus"
xref: Reactome:REACT_79874 "Scavenging of the 7-methylguanosine Cap by DCPS, Taeniopygia guttata"
xref: Reactome:REACT_87278 "Scavenging of the 7-methylguanosine Cap by DCPS, Drosophila melanogaster"
xref: Reactome:REACT_88925 "Scavenging of the 7-methylguanosine Cap by DCPS, Caenorhabditis elegans"
xref: Reactome:REACT_90233 "Scavenging of the 7-methylguanosine Cap by DCPS, Canis familiaris"
xref: Reactome:REACT_94168 "Scavenging of the 7-methylguanosine Cap by DCPS, Schizosaccharomyces pombe"
xref: Reactome:REACT_99687 "Scavenging of the 7-methylguanosine Cap by DCPS, Mus musculus"
xref: Reactome:REACT_99790 "Scavenging of the 7-methylguanosine Cap by DCPS, Saccharomyces cerevisiae"
is_a: GO:0004527 ! exonuclease activity
is_a: GO:0004540 ! ribonuclease activity
relationship: part_of GO:0090503 ! RNA phosphodiester bond hydrolysis, exonucleolytic

[Term]
id: GO:0004533
name: exoribonuclease H activity
namespace: molecular_function
def: "Catalysis of the exonucleolytic cleavage of RNA to 5'-phosphomonoester oligonucleotides in both 5' to 3' and 3' to 5' directions." [EC:3.1.13.2, ISBN:0198547684]
synonym: "retroviral reverse transcriptase RNaseH" RELATED [EC:3.1.13.2]
xref: EC:3.1.13.2
xref: MetaCyc:3.1.13.2-RXN
is_a: GO:0016896 ! exoribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0004534
name: 5'-3' exoribonuclease activity
namespace: molecular_function
def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684]
xref: EC:3.1.13.-
xref: Reactome:REACT_104850 "5' to 3' Exoribonuclease Digestion of Decapped mRNA, Mus musculus"
xref: Reactome:REACT_112693 "5' to 3' Exoribonuclease Digestion of Decapped mRNA, Plasmodium falciparum"
xref: Reactome:REACT_112806 "5' to 3' Exoribonuclease Digestion of Decapped mRNA, Dictyostelium discoideum"
xref: Reactome:REACT_20533 "5' to 3' Exoribonuclease Digestion of Decapped mRNA, Homo sapiens"
xref: Reactome:REACT_20668 "5' to 3' Exoribonuclease Digestion of Decapped mRNA (yeast), Saccharomyces cerevisiae"
xref: Reactome:REACT_29760 "5' to 3' Exoribonuclease Digestion of Decapped mRNA, Xenopus tropicalis"
xref: Reactome:REACT_31570 "5' to 3' Exoribonuclease Digestion of Decapped mRNA, Schizosaccharomyces pombe"
xref: Reactome:REACT_81547 "5' to 3' Exoribonuclease Digestion of Decapped mRNA, Bos taurus"
xref: Reactome:REACT_87069 "5' to 3' Exoribonuclease Digestion of Decapped mRNA, Caenorhabditis elegans"
xref: Reactome:REACT_90919 "5' to 3' Exoribonuclease Digestion of Decapped mRNA, Canis familiaris"
xref: Reactome:REACT_94602 "5' to 3' Exoribonuclease Digestion of Decapped mRNA, Danio rerio"
xref: Reactome:REACT_96418 "5' to 3' Exoribonuclease Digestion of Decapped mRNA, Drosophila melanogaster"
xref: Reactome:REACT_97923 "5' to 3' Exoribonuclease Digestion of Decapped mRNA, Gallus gallus"
xref: Reactome:REACT_99261 "5' to 3' Exoribonuclease Digestion of Decapped mRNA, Taeniopygia guttata"
is_a: GO:0008409 ! 5'-3' exonuclease activity
is_a: GO:0016896 ! exoribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0004535
name: poly(A)-specific ribonuclease activity
namespace: molecular_function
def: "Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP." [EC:3.1.13.4, ISBN:0198547684]
synonym: "2',3'-exoribonuclease activity" RELATED [EC:3.1.13.4]
synonym: "3'-exoribonuclease activity" EXACT [EC:3.1.13.4]
synonym: "poly(A)-specific RNase activity" EXACT []
xref: EC:3.1.13.4
xref: MetaCyc:3.1.13.4-RXN
xref: Reactome:REACT_102015 "Partial Deadenylation of mRNA by the PAN2-PAN3 Complex, Xenopus tropicalis"
xref: Reactome:REACT_105563 "Partial Deadenylation of mRNA by the PAN2-PAN3 Complex, Canis familiaris"
xref: Reactome:REACT_106678 "Deadenylation of mRNA by PARN, Danio rerio"
xref: Reactome:REACT_106922 "Partial Deadenylation of mRNA by the PAN2-PAN3 Complex, Bos taurus"
xref: Reactome:REACT_109187 "Partial Deadenylation of mRNA by the PAN2-PAN3 Complex, Danio rerio"
xref: Reactome:REACT_111967 "Deadenylation of mRNA by PARN, Taeniopygia guttata"
xref: Reactome:REACT_112457 "Partial Deadenylation of mRNA by the PAN2-PAN3 Complex, Drosophila melanogaster"
xref: Reactome:REACT_114879 "Deadenylation of mRNA by the CCR4-NOT Complex, Taeniopygia guttata"
xref: Reactome:REACT_20606 "Partial Deadenylation of mRNA by the PAN2-PAN3 Complex, Homo sapiens"
xref: Reactome:REACT_20651 "Deadenylation of mRNA by the CCR4-NOT Complex, Homo sapiens"
xref: Reactome:REACT_20662 "Deadenylation of mRNA by PARN, Homo sapiens"
xref: Reactome:REACT_28182 "Deadenylation of mRNA by PARN, Mus musculus"
xref: Reactome:REACT_30223 "Deadenylation of mRNA by the CCR4-NOT Complex, Mus musculus"
xref: Reactome:REACT_83122 "Partial Deadenylation of mRNA by the PAN2-PAN3 Complex, Mus musculus"
xref: Reactome:REACT_85613 "Deadenylation of mRNA by the CCR4-NOT Complex, Canis familiaris"
xref: Reactome:REACT_89076 "Partial Deadenylation of mRNA by the PAN2-PAN3 Complex, Taeniopygia guttata"
xref: Reactome:REACT_91463 "Deadenylation of mRNA by PARN, Canis familiaris"
xref: Reactome:REACT_92139 "Deadenylation of mRNA by the CCR4-NOT Complex, Danio rerio"
xref: Reactome:REACT_97042 "Partial Deadenylation of mRNA by the PAN2-PAN3 Complex, Rattus norvegicus"
is_a: GO:0000175 ! 3'-5'-exoribonuclease activity

[Term]
id: GO:0004536
name: deoxyribonuclease activity
namespace: molecular_function
alt_id: GO:0004537
def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid." [GOC:mah, ISBN:0198547684]
subset: gosubset_prok
synonym: "caspase-activated deoxyribonuclease activity" NARROW []
xref: Reactome:REACT_100642 "Cleavage of DNA by DFF40, Xenopus tropicalis"
xref: Reactome:REACT_101208 "Cleavage of DNA by DFF40, Bos taurus"
xref: Reactome:REACT_110575 "Cleavage of DNA by DFF40, Sus scrofa"
xref: Reactome:REACT_13702 "Cleavage of DNA by DFF40, Homo sapiens"
xref: Reactome:REACT_29722 "Cleavage of DNA by DFF40, Danio rerio"
xref: Reactome:REACT_31853 "Cleavage of DNA by DFF40, Taeniopygia guttata"
xref: Reactome:REACT_90424 "Cleavage of DNA by DFF40, Gallus gallus"
xref: Reactome:REACT_95359 "Cleavage of DNA by DFF40, Rattus norvegicus"
xref: Reactome:REACT_98682 "Cleavage of DNA by DFF40, Canis familiaris"
is_a: GO:0004518 ! nuclease activity
relationship: part_of GO:0006259 ! DNA metabolic process

[Term]
id: GO:0004540
name: ribonuclease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:mah, ISBN:0198547684]
subset: gosubset_prok
is_a: GO:0004518 ! nuclease activity
relationship: part_of GO:0090501 ! RNA phosphodiester bond hydrolysis

[Term]
id: GO:0004549
name: tRNA-specific ribonuclease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of phosphodiester bonds in tRNA molecules." [GOC:mah]
subset: gosubset_prok
synonym: "tRNA-specific RNase activity" EXACT []
is_a: GO:0004540 ! ribonuclease activity

[Term]
id: GO:0004550
name: nucleoside diphosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate." [EC:2.7.4.6]
subset: gosubset_prok
synonym: "ATP:nucleoside-diphosphate phosphotransferase activity" EXACT [EC:2.7.4.6]
synonym: "NDK activity" EXACT [EC:2.7.4.6]
synonym: "nucleoside 5'-diphosphate kinase activity" EXACT [EC:2.7.4.6]
synonym: "nucleoside 5'-diphosphate phosphotransferase activity" EXACT [EC:2.7.4.6]
synonym: "nucleoside diphosphate (UDP) kinase activity" EXACT [EC:2.7.4.6]
synonym: "nucleoside diphosphokinase activity" EXACT [EC:2.7.4.6]
synonym: "nucleoside-diphosphate kinase activity" EXACT []
synonym: "nucleotide phosphate kinase activity" EXACT [EC:2.7.4.6]
synonym: "UDP kinase activity" EXACT [EC:2.7.4.6]
synonym: "uridine diphosphate kinase activity" EXACT [EC:2.7.4.6]
xref: EC:2.7.4.6
xref: MetaCyc:NUCLEOSIDE-DIP-KIN-RXN
xref: Reactome:REACT_21273 "(d)NTP + ADP <=> (d)NDP + ATP [NME1,2,3], Homo sapiens"
xref: Reactome:REACT_21292 "(d)NTP + ADP <=> (d)NDP + ATP [NME4], Homo sapiens"
xref: Reactome:REACT_21362 "(d)NDP + ATP <=> (d)NTP + ADP [NME4], Homo sapiens"
xref: Reactome:REACT_21416 "(d)NDP + ATP <=> (d)NTP + ADP [NME1,2,3], Homo sapiens"
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor
is_a: GO:0019205 ! nucleobase-containing compound kinase activity
relationship: part_of GO:0006165 ! nucleoside diphosphate phosphorylation

[Term]
id: GO:0004551
name: nucleotide diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: a dinucleotide + H2O = 2 mononucleotides." [EC:3.6.1.9]
subset: gosubset_prok
synonym: "dinucleotide nucleotidohydrolase activity" EXACT [EC:3.6.1.9]
synonym: "nucleotide pyrophosphatase activity" EXACT []
synonym: "nucleotide-sugar pyrophosphatase activity" EXACT [EC:3.6.1.9]
xref: EC:3.6.1.9
xref: MetaCyc:NUCLEOTIDE-PYROPHOSPHATASE-RXN
xref: Reactome:REACT_100849 "FAD can be hydrolyzed back to FMN, Saccharomyces cerevisiae"
xref: Reactome:REACT_101743 "FAD can be hydrolyzed back to FMN, Dictyostelium discoideum"
xref: Reactome:REACT_105775 "FAD can be hydrolyzed back to FMN, Schizosaccharomyces pombe"
xref: Reactome:REACT_11150 "FAD can be hydrolyzed back to FMN, Homo sapiens"
xref: Reactome:REACT_114734 "FAD can be hydrolyzed back to FMN, Xenopus tropicalis"
xref: Reactome:REACT_31241 "FAD can be hydrolyzed back to FMN, Bos taurus"
xref: Reactome:REACT_32231 "FAD can be hydrolyzed back to FMN, Danio rerio"
xref: Reactome:REACT_32788 "FAD can be hydrolyzed back to FMN, Mus musculus"
xref: Reactome:REACT_79725 "FAD can be hydrolyzed back to FMN, Taeniopygia guttata"
xref: Reactome:REACT_81072 "FAD can be hydrolyzed back to FMN, Oryza sativa"
xref: Reactome:REACT_85470 "FAD can be hydrolyzed back to FMN, Sus scrofa"
xref: Reactome:REACT_88676 "FAD can be hydrolyzed back to FMN, Rattus norvegicus"
xref: Reactome:REACT_90125 "FAD can be hydrolyzed back to FMN, Canis familiaris"
xref: Reactome:REACT_90152 "FAD can be hydrolyzed back to FMN, Arabidopsis thaliana"
xref: Reactome:REACT_93217 "FAD can be hydrolyzed back to FMN, Gallus gallus"
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0004552
name: octanol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-octanol + NAD(+) = 1-octanal + H(+) + NADH." [EC:1.1.1.73, RHEA:24623]
synonym: "1-octanol dehydrogenase activity" EXACT [EC:1.1.1.73]
synonym: "octanol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.73]
xref: EC:1.1.1.73
xref: KEGG:R02878
xref: MetaCyc:OCTANOL-DEHYDROGENASE-RXN
xref: RHEA:24623
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004553
name: hydrolase activity, hydrolyzing O-glycosyl compounds
namespace: molecular_function
alt_id: GO:0016800
def: "Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]
subset: gosubset_prok
synonym: "O-glucosyl hydrolase activity" EXACT []
xref: EC:3.2.1
is_a: GO:0016798 ! hydrolase activity, acting on glycosyl bonds

[Term]
id: GO:0004555
name: alpha,alpha-trehalase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha,alpha-trehalose + H2O = 2 D-glucose." [EC:3.2.1.28]
subset: gosubset_prok
synonym: "alpha,alpha-trehalose glucohydrolase activity" EXACT [EC:3.2.1.28]
xref: EC:3.2.1.28
xref: MetaCyc:TREHALA-RXN
xref: Reactome:REACT_100752 "trehalose + H2O => 2 D-glucose, Dictyostelium discoideum"
xref: Reactome:REACT_107937 "trehalose + H2O => 2 D-glucose, Caenorhabditis elegans"
xref: Reactome:REACT_108455 "trehalose + H2O => 2 D-glucose, Mus musculus"
xref: Reactome:REACT_113083 "trehalose + H2O => 2 D-glucose, Escherichia coli"
xref: Reactome:REACT_28802 "trehalose + H2O => 2 D-glucose, Rattus norvegicus"
xref: Reactome:REACT_33073 "trehalose + H2O => 2 D-glucose, Bos taurus"
xref: Reactome:REACT_62235 "trehalose + H2O => 2 D-glucose, Canis familiaris"
xref: Reactome:REACT_83023 "trehalose + H2O => 2 D-glucose, Oryza sativa"
xref: Reactome:REACT_85697 "trehalose + H2O => 2 D-glucose, Xenopus tropicalis"
xref: Reactome:REACT_86912 "trehalose + H2O => 2 D-glucose, Schizosaccharomyces pombe"
xref: Reactome:REACT_88617 "trehalose + H2O => 2 D-glucose, Danio rerio"
xref: Reactome:REACT_91694 "trehalose + H2O => 2 D-glucose, Arabidopsis thaliana"
xref: Reactome:REACT_9425 "trehalose + H2O => 2 D-glucose, Homo sapiens"
xref: Reactome:REACT_9495 "trehalose + H2O => 2 D-glucose, Oryctolagus cuniculus"
xref: Reactome:REACT_96425 "trehalose + H2O => 2 D-glucose, Drosophila melanogaster"
xref: RHEA:20871
is_a: GO:0015927 ! trehalase activity

[Term]
id: GO:0004556
name: alpha-amylase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more alpha-(1->4)-linked D-glucose units." [EC:3.2.1.1]
subset: gosubset_prok
synonym: "1,4-alpha-D-glucan glucanohydrolase activity" EXACT [EC:3.2.1.1]
synonym: "alpha amylase activity" EXACT [EC:3.2.1.1]
synonym: "endoamylase activity" EXACT [EC:3.2.1.1]
synonym: "glycogenase activity" BROAD [EC:3.2.1.1]
synonym: "taka-amylase A" RELATED [EC:3.2.1.1]
xref: EC:3.2.1.1
xref: MetaCyc:ALPHA-AMYL-RXN
xref: MetaCyc:RXN-1823
xref: MetaCyc:RXN-1825
xref: Reactome:REACT_103700 "Digestion of linear starch (amylose) by extracellular amylase, Canis familiaris"
xref: Reactome:REACT_104713 "Digestion of linear starch (amylose) by extracellular amylase, Taeniopygia guttata"
xref: Reactome:REACT_107842 "Digestion of linear starch (amylose) by extracellular amylase, Sus scrofa"
xref: Reactome:REACT_108543 "Digestion of branched starch (amylopectin) by extracellular amylase, Mus musculus"
xref: Reactome:REACT_108602 "Digestion of linear starch (amylose) by extracellular amylase, Rattus norvegicus"
xref: Reactome:REACT_108724 "Digestion of branched starch (amylopectin) by extracellular amylase, Rattus norvegicus"
xref: Reactome:REACT_108878 "Digestion of linear starch (amylose) by extracellular amylase, Bos taurus"
xref: Reactome:REACT_28419 "Digestion of linear starch (amylose) by extracellular amylase, Danio rerio"
xref: Reactome:REACT_29745 "Digestion of branched starch (amylopectin) by extracellular amylase, Sus scrofa"
xref: Reactome:REACT_31483 "Digestion of branched starch (amylopectin) by extracellular amylase, Bos taurus"
xref: Reactome:REACT_32139 "Digestion of branched starch (amylopectin) by extracellular amylase, Danio rerio"
xref: Reactome:REACT_33479 "Digestion of branched starch (amylopectin) by extracellular amylase, Canis familiaris"
xref: Reactome:REACT_79894 "Digestion of branched starch (amylopectin) by extracellular amylase, Drosophila melanogaster"
xref: Reactome:REACT_80072 "Digestion of linear starch (amylose) by extracellular amylase, Caenorhabditis elegans"
xref: Reactome:REACT_87127 "Digestion of branched starch (amylopectin) by extracellular amylase, Gallus gallus"
xref: Reactome:REACT_88623 "Digestion of linear starch (amylose) by extracellular amylase, Xenopus tropicalis"
xref: Reactome:REACT_90361 "Digestion of linear starch (amylose) by extracellular amylase, Mus musculus"
xref: Reactome:REACT_90841 "Digestion of branched starch (amylopectin) by extracellular amylase, Caenorhabditis elegans"
xref: Reactome:REACT_90967 "Digestion of linear starch (amylose) by extracellular amylase, Drosophila melanogaster"
xref: Reactome:REACT_91720 "Digestion of branched starch (amylopectin) by extracellular amylase, Taeniopygia guttata"
xref: Reactome:REACT_93726 "Digestion of branched starch (amylopectin) by extracellular amylase, Xenopus tropicalis"
xref: Reactome:REACT_9403 "Digestion of linear starch (amylose) by extracellular amylase, Homo sapiens"
xref: Reactome:REACT_94289 "Digestion of linear starch (amylose) by extracellular amylase, Gallus gallus"
xref: Reactome:REACT_9475 "Digestion of branched starch (amylopectin) by extracellular amylase, Homo sapiens"
is_a: GO:0016160 ! amylase activity

[Term]
id: GO:0004557
name: alpha-galactosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactohydrolase." [EC:3.2.1.22]
subset: gosubset_prok
synonym: "alpha-D-galactosidase activity" EXACT [EC:3.2.1.22]
synonym: "alpha-D-galactoside galactohydrolase activity" EXACT [EC:3.2.1.22]
synonym: "alpha-galactosidase A" RELATED [EC:3.2.1.22]
synonym: "alpha-galactoside galactohydrolase activity" EXACT [EC:3.2.1.22]
synonym: "melibiase activity" EXACT []
xref: EC:3.2.1.22
xref: MetaCyc:ALPHAGALACTOSID-RXN
xref: Reactome:REACT_115752 "Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers, Homo sapiens"
is_a: GO:0015925 ! galactosidase activity

[Term]
id: GO:0004558
name: alpha-1,4-glucosidase activity
namespace: molecular_function
alt_id: GO:0004562
alt_id: GO:0016982
def: "Catalysis of the hydrolysis of terminal, non-reducing alpha-(1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose." [EC:3.2.1.20]
subset: gosubset_prok
synonym: "acid maltase activity" EXACT [EC:3.2.1.20]
synonym: "alpha-1,4-glucosidase activity" EXACT [EC:3.2.1.20]
synonym: "alpha-D-glucosidase activity" EXACT [EC:3.2.1.20]
synonym: "alpha-D-glucoside glucohydrolase activity" EXACT [EC:3.2.1.20]
synonym: "alpha-glucopyranosidase activity" EXACT [EC:3.2.1.20]
synonym: "alpha-glucosidase II" RELATED []
synonym: "alpha-glucoside hydrolase activity" EXACT [EC:3.2.1.20]
synonym: "glucoinvertase activity" EXACT [EC:3.2.1.20]
synonym: "glucosidoinvertase activity" EXACT [EC:3.2.1.20]
synonym: "glucosidosucrase activity" EXACT [EC:3.2.1.20]
synonym: "lysosomal alpha-glucosidase activity" BROAD [EC:3.2.1.20]
synonym: "maltase-glucoamylase activity" EXACT [EC:3.2.1.20]
xref: EC:3.2.1.20
xref: MetaCyc:MALTODEXGLUCOSID-RXN
xref: Reactome:REACT_100920 "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose, Rattus norvegicus"
xref: Reactome:REACT_102012 "maltose + H2O => 2 D-glucose (sucrase-isomaltase), Canis familiaris"
xref: Reactome:REACT_103965 "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase), Sus scrofa"
xref: Reactome:REACT_103976 "maltose + H2O => 2 D-glucose (sucrase-isomaltase), Danio rerio"
xref: Reactome:REACT_108880 "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase), Rattus norvegicus"
xref: Reactome:REACT_112486 "maltose + H2O => 2 D-glucose (sucrase-isomaltase), Taeniopygia guttata"
xref: Reactome:REACT_113312 "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose, Taeniopygia guttata"
xref: Reactome:REACT_114036 "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase), Taeniopygia guttata"
xref: Reactome:REACT_32591 "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase), Bos taurus"
xref: Reactome:REACT_53202 "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose, Sus scrofa"
xref: Reactome:REACT_80032 "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose, Canis familiaris"
xref: Reactome:REACT_82469 "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose, Mus musculus"
xref: Reactome:REACT_82683 "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase), Mus musculus"
xref: Reactome:REACT_84778 "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose, Bos taurus"
xref: Reactome:REACT_84962 "maltose + H2O => 2 D-glucose (sucrase-isomaltase), Xenopus tropicalis"
xref: Reactome:REACT_88169 "maltose + H2O => 2 D-glucose (sucrase-isomaltase), Rattus norvegicus"
xref: Reactome:REACT_88678 "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase), Xenopus tropicalis"
xref: Reactome:REACT_88835 "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose, Xenopus tropicalis"
xref: Reactome:REACT_89837 "maltose + H2O => 2 D-glucose (sucrase-isomaltase), Bos taurus"
xref: Reactome:REACT_94010 "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase), Danio rerio"
xref: Reactome:REACT_9414 "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose, Homo sapiens"
xref: Reactome:REACT_9424 "maltose + H2O => 2 D-glucose (maltase-glucoamylase), Homo sapiens"
xref: Reactome:REACT_9426 "maltose + H2O => 2 D-glucose (sucrase-isomaltase), Homo sapiens"
xref: Reactome:REACT_9479 "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase), Homo sapiens"
xref: Reactome:REACT_9506 "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase), Homo sapiens"
xref: Reactome:REACT_95331 "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase), Canis familiaris"
xref: Reactome:REACT_97286 "maltose + H2O => 2 D-glucose (sucrase-isomaltase), Mus musculus"
xref: Reactome:REACT_97290 "maltose + H2O => 2 D-glucose (sucrase-isomaltase), Sus scrofa"
xref: Reactome:REACT_97456 "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose, Danio rerio"
is_a: GO:0090599 ! alpha-glucosidase activity

[Term]
id: GO:0004559
name: alpha-mannosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides." [EC:3.2.1.24]
subset: gosubset_prok
synonym: "1,2-alpha-D-mannosidase activity" NARROW [EC:3.2.1.24]
synonym: "1,2-alpha-mannosidase" NARROW [EC:3.2.1.24]
synonym: "alpha-D-mannopyranosidase activity" EXACT [EC:3.2.1.24]
synonym: "alpha-D-mannosidase activity" EXACT [EC:3.2.1.24]
synonym: "alpha-D-mannoside mannohydrolase activity" EXACT [EC:3.2.1.24]
synonym: "exo-alpha-mannosidase activity" EXACT [EC:3.2.1.24]
synonym: "p-nitrophenyl-alpha-mannosidase activity" NARROW [EC:3.2.1.24]
xref: EC:3.2.1.24
xref: MetaCyc:3.2.1.24-RXN
xref: Reactome:REACT_24995 "Trimming of the terminal mannose on the B branch, Homo sapiens"
xref: Reactome:REACT_25093 "Trimming of the first mannose on the A branch, Homo sapiens"
xref: Reactome:REACT_25126 "Trimming of the terminal mannose on the C branch, Homo sapiens"
xref: Reactome:REACT_25313 "Trimming of the second mannose on the A branch, Homo sapiens"
is_a: GO:0015923 ! mannosidase activity

[Term]
id: GO:0004560
name: alpha-L-fucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: an alpha-L-fucoside + H2O = an alcohol + L-fucose." [EC:3.2.1.51]
subset: gosubset_prok
synonym: "alpha-fucosidase activity" EXACT [EC:3.2.1.51]
synonym: "alpha-L-fucoside fucohydrolase activity" EXACT [EC:3.2.1.51]
xref: EC:3.2.1.51
xref: MetaCyc:ALPHA-L-FUCOSIDASE-RXN
is_a: GO:0015928 ! fucosidase activity

[Term]
id: GO:0004561
name: alpha-N-acetylglucosaminidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides." [EC:3.2.1.50]
synonym: "alpha-acetylglucosaminidase activity" EXACT [EC:3.2.1.50]
synonym: "alpha-D-2-acetamido-2-deoxyglucosidase activity" EXACT [EC:3.2.1.50]
synonym: "alpha-N-acetyl-D-glucosaminide N-acetylglucosaminohydrolase activity" EXACT [EC:3.2.1.50]
synonym: "N-acetyl-alpha-D-glucosaminidase activity" EXACT [EC:3.2.1.50]
synonym: "N-acetyl-alpha-glucosaminidase activity" EXACT [EC:3.2.1.50]
synonym: "NAG activity" EXACT [EC:3.2.1.50]
xref: EC:3.2.1.50
xref: MetaCyc:3.2.1.50-RXN
is_a: GO:0015929 ! hexosaminidase activity

[Term]
id: GO:0004563
name: beta-N-acetylhexosaminidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides." [EC:3.2.1.52]
subset: gosubset_prok
synonym: "beta-acetylaminodeoxyhexosidase activity" EXACT [EC:3.2.1.52]
synonym: "beta-acetylhexosaminidinase activity" EXACT [EC:3.2.1.52]
synonym: "beta-D-hexosaminidase activity" EXACT [EC:3.2.1.52]
synonym: "beta-D-N-acetylhexosaminidase activity" EXACT [EC:3.2.1.52]
synonym: "beta-hexosaminidase activity" EXACT [EC:3.2.1.52]
synonym: "beta-N-acetyl-D-hexosaminidase activity" EXACT [EC:3.2.1.52]
synonym: "beta-N-acetyl-D-hexosaminide N-acetylhexosaminohydrolase activity" EXACT [EC:3.2.1.52]
synonym: "hexosaminidase A" RELATED [EC:3.2.1.52]
synonym: "N-acetyl-beta-D-hexosaminidase activity" EXACT [EC:3.2.1.52]
synonym: "N-acetyl-beta-glucosaminidase activity" EXACT [EC:3.2.1.52]
synonym: "N-acetyl-beta-hexosaminidase activity" EXACT [EC:3.2.1.52]
synonym: "N-acetylhexosaminidase activity" EXACT [EC:3.2.1.52]
xref: EC:3.2.1.52
xref: MetaCyc:3.2.1.52-RXN
xref: Reactome:REACT_115753 "Both hexosaminidase A and B can cleave GalNAc from globoside, Homo sapiens"
xref: Reactome:REACT_115984 "Hexosaminidase A cleaves GalNAc from GM2 to form GM3, Homo sapiens"
is_a: GO:0015929 ! hexosaminidase activity

[Term]
id: GO:0004564
name: beta-fructofuranosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a fructofuranosylated fructofuranosyl acceptor + H2O = a non fructofuranosylated fructofuranosyl acceptor + a beta-D-fructofuranoside." [EC:3.2.1.26, MetaCyc:RXN-9985]
subset: gosubset_prok
synonym: "acid invertase activity" BROAD []
synonym: "alkaline invertase activity" BROAD []
synonym: "beta-D-fructofuranoside fructohydrolase activity" EXACT []
synonym: "beta-fructosidase activity" RELATED []
synonym: "beta-h-fructosidase activity" RELATED []
synonym: "fructosylinvertase activity" RELATED []
synonym: "glucosucrase activity" RELATED []
synonym: "invertase activity" BROAD []
synonym: "invertin activity" BROAD []
synonym: "maxinvert L 1000 activity" RELATED []
synonym: "saccharase activity" RELATED []
xref: EC:3.2.1.26
xref: MetaCyc:RXN-9985
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0004565
name: beta-galactosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides." [EC:3.2.1.23]
comment: Note that the inclusion of 'MetaCyc:BGALACT-PWY' is exceptional: normally MetaCyc pathway entries are database references for biological process terms, not molecular function terms. An exception was made in this case because the MetaCyc entry 'BGALACT-PWY' describes only one reaction, that catalyzed by beta-galactosidase.
subset: gosubset_prok
synonym: "beta-D-galactanase activity" EXACT [EC:3.2.1.23]
synonym: "beta-D-galactoside galactohydrolase activity" EXACT [EC:3.2.1.23]
synonym: "beta-D-lactosidase activity" EXACT [EC:3.2.1.23]
synonym: "beta-lactosidase activity" EXACT [EC:3.2.1.23]
synonym: "exo-(1->4)-beta-D-galactanase activity" EXACT [EC:3.2.1.23]
synonym: "hydrolact" RELATED [EC:3.2.1.23]
synonym: "lactose hydrolysis" RELATED []
synonym: "lactozym" RELATED [EC:3.2.1.23]
synonym: "maxilact" RELATED [EC:3.2.1.23]
synonym: "oryzatym" RELATED [EC:3.2.1.23]
synonym: "S 2107" RELATED [EC:3.2.1.23]
synonym: "sumiklat" RELATED [EC:3.2.1.23]
synonym: "trilactase activity" EXACT [EC:3.2.1.23]
xref: EC:3.2.1.23
xref: MetaCyc:3.2.1.23-RXN
xref: MetaCyc:BGALACT-PWY
xref: Reactome:REACT_115597 "Beta-galactosidase can also hydrolyse globosides to form cerebrosides, Homo sapiens"
xref: Reactome:REACT_115930 "Beta-galactosidase hydrolyses GM1 to GM2, Homo sapiens"
is_a: GO:0015925 ! galactosidase activity

[Term]
id: GO:0004566
name: beta-glucuronidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate." [EC:3.2.1.31]
subset: gosubset_prok
synonym: "beta-D-glucuronoside glucuronosohydrolase activity" EXACT [EC:3.2.1.31]
synonym: "beta-glucuronide glucuronohydrolase activity" EXACT [EC:3.2.1.31]
synonym: "exo-beta-D-glucuronidase activity" EXACT [EC:3.2.1.31]
synonym: "glucuronidase activity" EXACT [EC:3.2.1.31]
synonym: "ketodase activity" EXACT [EC:3.2.1.31]
xref: EC:3.2.1.31
xref: MetaCyc:BETA-GLUCURONID-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0004567
name: beta-mannosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides." [EC:3.2.1.25]
subset: gosubset_prok
synonym: "beta-D-mannosidase activity" EXACT [EC:3.2.1.25]
synonym: "beta-D-mannoside mannohydrolase activity" EXACT [EC:3.2.1.25]
synonym: "beta-mannoside mannohydrolase activity" EXACT [EC:3.2.1.25]
synonym: "exo-beta-D-mannanase activity" EXACT [EC:3.2.1.25]
synonym: "mannanase activity" EXACT [EC:3.2.1.25]
synonym: "mannase activity" EXACT [EC:3.2.1.25]
xref: EC:3.2.1.25
xref: MetaCyc:3.2.1.25-RXN
is_a: GO:0015923 ! mannosidase activity

[Term]
id: GO:0004568
name: chitinase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins." [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293]
subset: gosubset_prok
synonym: "1,4-beta-poly-N-acetylglucosaminidase activity" EXACT [EC:3.2.1.14]
synonym: "beta-1,4-poly-N-acetyl glucosamidinase activity" EXACT [EC:3.2.1.14]
synonym: "chitodextrinase activity" EXACT [EC:3.2.1.14]
synonym: "poly-beta-glucosaminidase activity" EXACT [EC:3.2.1.14]
synonym: "poly[1,4-(N-acetyl-beta-D-glucosaminide)] glycanohydrolase activity" EXACT [EC:3.2.1.14]
xref: EC:3.2.1.14
xref: MetaCyc:3.2.1.14-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0004569
name: glycoprotein endo-alpha-1,2-mannosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the terminal alpha-glucosyl-(1,3)-mannosyl unit from Glc-Man(9)-(GlcNAc)(2) oligosaccharide component of the glycoprotein produced in the Golgi membrane." [EC:3.2.1.130]
synonym: "endo-alpha-mannosidase activity" EXACT [EC:3.2.1.130]
synonym: "endomannosidase activity" EXACT [EC:3.2.1.130]
synonym: "glucosyl mannosidase activity" EXACT [EC:3.2.1.130]
synonym: "glucosylmannosidase activity" EXACT [EC:3.2.1.130]
synonym: "glycoprotein glucosylmannohydrolase activity" EXACT [EC:3.2.1.130]
xref: EC:3.2.1.130
xref: MetaCyc:3.2.1.130-RXN
xref: Reactome:REACT_25136 "Alternative endo-mannosidase I route, Homo sapiens"
is_a: GO:0004559 ! alpha-mannosidase activity

[Term]
id: GO:0004571
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in an oligo-mannose oligosaccharide." [GOC:bf, PMID:25092655]
subset: gosubset_prok
synonym: "1,2-alpha-mannosidase" EXACT [EC:3.2.1.113]
synonym: "1,2-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase activity" EXACT [EC:3.2.1.113]
synonym: "exo-alpha-1,2-mannanase activity" EXACT [EC:3.2.1.113]
synonym: "glycoprotein processing mannosidase I" RELATED [EC:3.2.1.113]
synonym: "Man9-mannosidase activity" NARROW [EC:3.2.1.113]
synonym: "man9-mannosidase activity" NARROW [EC:3.2.1.113]
synonym: "ManI activity" NARROW [EC:3.2.1.113]
synonym: "mannose-9 processing alpha-mannosidase activity" NARROW [EC:3.2.1.113]
synonym: "mannosidase 1A activity" NARROW [EC:3.2.1.113]
synonym: "mannosidase 1B activity" NARROW [EC:3.2.1.113]
synonym: "mannosidase I" RELATED [EC:3.2.1.113]
xref: EC:3.2.1.113
xref: KEGG:R05982
xref: KEGG:R06722
xref: MetaCyc:3.2.1.113-RXN
xref: Reactome:REACT_25205 "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2, Homo sapiens"
xref: Reactome:REACT_25217 "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2, Homo sapiens"
xref: Reactome:REACT_25341 "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2, Homo sapiens"
is_a: GO:0015924 ! mannosyl-oligosaccharide mannosidase activity

[Term]
id: GO:0004572
name: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the terminal (1->3)- and (1->6)-linked alpha-D-mannose residues in the mannosyl-oligosaccharide Man(5)(GlcNAc)(3)." [EC:3.2.1.114]
synonym: "1,3-(1,6-)mannosyl-oligosaccharide alpha-D-mannohydrolase activity" EXACT [EC:3.2.1.114]
synonym: "alpha-(1,3/6)-mannosidase activity" EXACT [EC:3.2.1.114]
synonym: "alpha-D-mannosidase II" RELATED [EC:3.2.1.114]
synonym: "alpha-mannosidase II" RELATED [EC:3.2.1.114]
synonym: "exo-1,3-1,6-alpha-mannosidase activity" EXACT [EC:3.2.1.114]
synonym: "GlcNAc transferase I-dependent alpha1,3[alpha1,6]mannosidase activity" EXACT [EC:3.2.1.114]
synonym: "Golgi alpha-mannosidase II" RELATED [EC:3.2.1.114]
synonym: "ManII activity" NARROW [EC:3.2.1.114]
synonym: "mannosidase II activity" NARROW [EC:3.2.1.114]
synonym: "mannosyl-oligosaccharide (1->3)-(1->6)-alpha-mannosidase activity" EXACT []
synonym: "mannosyl-oligosaccharide (1->3,6)-alpha-mannosidase activity" EXACT []
synonym: "mannosyl-oligosaccharide (1->3/6)-alpha-mannosidase activity" EXACT []
xref: EC:3.2.1.114
xref: MetaCyc:3.2.1.114-RXN
xref: Reactome:REACT_25047 "Trimming of mannoses on the alpha1,6 arm by MAN2A1, Homo sapiens"
is_a: GO:0015924 ! mannosyl-oligosaccharide mannosidase activity

[Term]
id: GO:0004573
name: mannosyl-oligosaccharide glucosidase activity
namespace: molecular_function
def: "Catalysis of the exohydrolysis of the non-reducing terminal glucose residue in the mannosyl-oligosaccharide Glc(3)Man(9)GlcNAc(2)." [EC:3.2.1.106]
synonym: "Glc3Man9NAc2 oligosaccharide glucosidase activity" EXACT [EC:3.2.1.106]
synonym: "mannosyl-oligosaccharide glucohydrolase activity" EXACT [EC:3.2.1.106]
synonym: "mannosyl-oligosaccharide glucosidase (processing A-glucosidase I) activity" EXACT []
synonym: "processing A-glucosidase I activity" RELATED [EC:3.2.1.106]
synonym: "trimming glucosidase I" RELATED [EC:3.2.1.106]
xref: EC:3.2.1.106
xref: MetaCyc:3.2.1.106-RXN
xref: Reactome:REACT_23855 "Trimming of the first glucose by glucosidase I, Homo sapiens"
is_a: GO:0015926 ! glucosidase activity

[Term]
id: GO:0004574
name: oligo-1,6-glucosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in some oligosaccharides produced from starch and glycogen by alpha-amylase, and in isomaltose. Releases a free alpha-D-glucose." [EC:3.2.1.10]
subset: gosubset_prok
synonym: "alpha-limit dextrinase activity" EXACT [EC:3.2.1.10]
synonym: "alpha-methylglucosidase activity" RELATED [GOC:rb]
synonym: "dextrin 6-glucanohydrolase activity" EXACT [EC:3.2.1.10]
synonym: "dextrin 6alpha-glucanohydrolase activity" EXACT [EC:3.2.1.10]
synonym: "exo-oligo-1,6-glucosidase activity" EXACT [EC:3.2.1.10]
synonym: "isomaltase activity" RELATED [EC:3.2.1.10]
synonym: "limit dextrinase (erroneous)" BROAD [EC:3.2.1.10]
synonym: "oligosaccharide alpha-1,6-glucohydrolase activity" EXACT [EC:3.2.1.10]
synonym: "oligosaccharide alpha-1,6-glucosidase activity" EXACT [EC:3.2.1.10]
synonym: "sucrase-isomaltase activity" RELATED [EC:3.2.1.10]
xref: EC:3.2.1.10
xref: MetaCyc:3.2.1.10-RXN
is_a: GO:0090599 ! alpha-glucosidase activity

[Term]
id: GO:0004575
name: sucrose alpha-glucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: sucrose + H2O = alpha-D-glucose + beta-D-fructose." [EC:3.2.1.48, MetaCyc:RXN-1461]
synonym: "alpha-D-glucopyranosyl beta-D-fructofuranoside hydrolysis" BROAD []
synonym: "beta-D-fructofuranosyl alpha-D-glucopyranoside hydrolysis" BROAD []
synonym: "intestinal sucrase activity" RELATED [EC:3.2.1.48]
synonym: "sucrase activity" RELATED [EC:3.2.1.48]
synonym: "sucrase(invertase)" RELATED [EC:3.2.1.48]
synonym: "sucrase-isomaltase activity" RELATED [EC:3.2.1.48]
synonym: "sucrose alpha-D-glucohydrolase activity" EXACT []
synonym: "sucrose alpha-glucohydrolase activity" EXACT [EC:3.2.1.48]
synonym: "sucrose hydrolysis" BROAD []
synonym: "sucrose-alpha-D-glucohydrolase activity" EXACT [EC:3.2.1.48]
xref: EC:3.2.1.26
xref: EC:3.2.1.48
xref: KEGG:R00802
xref: MetaCyc:RXN-1461
xref: Reactome:REACT_109028 "sucrose + H2O => glucose + fructose, Bos taurus"
xref: Reactome:REACT_110486 "sucrose + H2O => glucose + fructose, Mus musculus"
xref: Reactome:REACT_113531 "sucrose + H2O => glucose + fructose, Taeniopygia guttata"
xref: Reactome:REACT_29388 "sucrose + H2O => glucose + fructose, Xenopus tropicalis"
xref: Reactome:REACT_31778 "sucrose + H2O => glucose + fructose, Danio rerio"
xref: Reactome:REACT_46717 "sucrose + H2O => glucose + fructose, Canis familiaris"
xref: Reactome:REACT_77700 "sucrose + H2O => glucose + fructose, Sus scrofa"
xref: Reactome:REACT_9409 "sucrose + H2O => glucose + fructose, Homo sapiens"
xref: Reactome:REACT_97464 "sucrose + H2O => glucose + fructose, Rattus norvegicus"
is_a: GO:0004564 ! beta-fructofuranosidase activity
is_a: GO:0090599 ! alpha-glucosidase activity

[Term]
id: GO:0004576
name: oligosaccharyl transferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a oligosaccharyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai]
subset: gosubset_prok
synonym: "oligosaccharide transferase activity" EXACT [EC:2.4.1.119, GOC:mah]
xref: EC:2.4.1.-
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0004577
name: N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosaminyl-diphosphodolichol = UDP + N,N''-diacetylchitobiosyldiphosphodolichol." [EC:2.4.1.141]
synonym: "N,N'-diacetylchitobiosylpyrophosphoryldolichol synthase activity" EXACT [EC:2.4.1.141]
synonym: "UDP-GlcNAc:dolichyl-pyrophosphoryl-GlcNAc GlcNAc transferase activity" EXACT [EC:2.4.1.141]
synonym: "UDP-N-acetyl-D-glucosamine:N-acetyl-D-glucosaminyl-diphosphodolichol N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.141]
synonym: "uridine diphosphoacetylglucosamine-dolichylacetylglucosamine pyrophosphate acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.141]
xref: EC:2.4.1.141
xref: MetaCyc:2.4.1.141-RXN
xref: Reactome:REACT_22332 "Addition of the second N-acetyl-glucosamine to the N-glycan precursor, Homo sapiens"
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0004578
name: chitobiosyldiphosphodolichol beta-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-mannose + chitobiosyldiphosphodolichol = GDP + beta-D-mannosylchitobiosyldiphosphodolichol." [EC:2.4.1.142]
synonym: "GDP-mannose-dolichol diphosphochitobiose mannosyltransferase activity" EXACT [EC:2.4.1.142]
synonym: "GDP-mannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase activity" EXACT [EC:2.4.1.142]
synonym: "guanosine diphosphomannose-dolichol diphosphochitobiose mannosyltransferase activity" EXACT [EC:2.4.1.142]
xref: EC:2.4.1.142
xref: MetaCyc:2.4.1.142-RXN
xref: Reactome:REACT_22214 "Addition of the first mannose to the N-glycan precursor by ALG13/14, Homo sapiens"
is_a: GO:0019187 ! beta-1,4-mannosyltransferase activity

[Term]
id: GO:0004579
name: dolichyl-diphosphooligosaccharide-protein glycotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine." [EC:2.4.1.119]
synonym: "asparagine N-glycosyltransferase activity" EXACT [EC:2.4.1.119]
synonym: "dolichyl-diphosphooligosaccharide-protein glycosyltransferase activity" EXACT []
synonym: "dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase activity" EXACT [EC:2.4.1.119]
synonym: "dolichyldiphosphooligosaccharide-protein glycosyltransferase activity" EXACT [EC:2.4.1.119]
synonym: "dolichyldiphosphooligosaccharide-protein oligosaccharyltransferase activity" EXACT [EC:2.4.1.119]
synonym: "dolichyldiphosphoryloligosaccharide-protein oligosaccharyltransferase activity" EXACT [EC:2.4.1.119]
synonym: "dolichylpyrophosphodiacetylchitobiose-protein glycosyltransferase activity" EXACT [EC:2.4.1.119]
synonym: "oligomannosyltransferase activity" RELATED [EC:2.4.1.119]
xref: EC:2.4.1.119
xref: MetaCyc:2.4.1.119-RXN
xref: Reactome:REACT_100173 "Transfer of N-glycan to the protein, Schizosaccharomyces pombe"
xref: Reactome:REACT_104542 "Transfer of N-glycan to the protein, Canis familiaris"
xref: Reactome:REACT_105113 "Transfer of N-glycan to the protein, Xenopus tropicalis"
xref: Reactome:REACT_107399 "Transfer of N-glycan to the protein, Caenorhabditis elegans"
xref: Reactome:REACT_108138 "Transfer of N-glycan to the protein, Mus musculus"
xref: Reactome:REACT_109815 "Transfer of N-glycan to the protein, Danio rerio"
xref: Reactome:REACT_110217 "Transfer of N-glycan to the protein, Sus scrofa"
xref: Reactome:REACT_22208 "Transfer of N-glycan to the protein, Homo sapiens"
xref: Reactome:REACT_28545 "Transfer of N-glycan to the protein, Rattus norvegicus"
xref: Reactome:REACT_32860 "Transfer of N-glycan to the protein, Saccharomyces cerevisiae"
xref: Reactome:REACT_32942 "Transfer of N-glycan to the protein, Drosophila melanogaster"
xref: Reactome:REACT_84238 "Transfer of N-glycan to the protein, Oryza sativa"
xref: Reactome:REACT_85218 "Transfer of N-glycan to the protein, Arabidopsis thaliana"
xref: Reactome:REACT_87422 "Transfer of N-glycan to the protein, Gallus gallus"
xref: Reactome:REACT_88737 "Transfer of N-glycan to the protein, Dictyostelium discoideum"
xref: Reactome:REACT_94087 "Transfer of N-glycan to the protein, Bos taurus"
xref: Reactome:REACT_95564 "Transfer of N-glycan to the protein, Taeniopygia guttata"
is_a: GO:0004576 ! oligosaccharyl transferase activity

[Term]
id: GO:0004581
name: dolichyl-phosphate beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + dolichyl phosphate = UDP + dolichyl beta-D-glucosyl phosphate." [EC:2.4.1.117]
subset: gosubset_prok
synonym: "polyprenyl phosphate:UDP-D-glucose glucosyltransferase activity" EXACT [EC:2.4.1.117]
synonym: "UDP-glucose dolichyl-phosphate glucosyltransferase activity" EXACT [EC:2.4.1.117]
synonym: "UDP-glucose:dolichol phosphate glucosyltransferase activity" EXACT [EC:2.4.1.117]
synonym: "UDP-glucose:dolicholphosphoryl glucosyltransferase activity" EXACT [EC:2.4.1.117]
synonym: "UDP-glucose:dolichyl monophosphate glucosyltransferase activity" EXACT [EC:2.4.1.117]
synonym: "UDP-glucose:dolichyl phosphate glucosyltransferase activity" EXACT [EC:2.4.1.117]
synonym: "UDP-glucose:dolichyl-phosphate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.117]
synonym: "UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.117]
synonym: "uridine diphosphoglucose-dolichol glucosyltransferase activity" EXACT [EC:2.4.1.117]
xref: EC:2.4.1.117
xref: MetaCyc:2.4.1.117-RXN
xref: Reactome:REACT_100680 "Synthesis of dolichyl-phosphate-glucose, Mus musculus"
xref: Reactome:REACT_104794 "Synthesis of dolichyl-phosphate-glucose, Canis familiaris"
xref: Reactome:REACT_104813 "Synthesis of dolichyl-phosphate-glucose, Drosophila melanogaster"
xref: Reactome:REACT_107904 "Synthesis of dolichyl-phosphate-glucose, Rattus norvegicus"
xref: Reactome:REACT_22143 "Synthesis of dolichyl-phosphate-glucose, Homo sapiens"
xref: Reactome:REACT_33304 "Synthesis of dolichyl-phosphate-glucose, Oryza sativa"
xref: Reactome:REACT_80993 "Synthesis of dolichyl-phosphate-glucose, Saccharomyces cerevisiae"
xref: Reactome:REACT_88104 "Synthesis of dolichyl-phosphate-glucose, Arabidopsis thaliana"
xref: Reactome:REACT_88352 "Synthesis of dolichyl-phosphate-glucose, Xenopus tropicalis"
xref: Reactome:REACT_89501 "Synthesis of dolichyl-phosphate-glucose, Taeniopygia guttata"
xref: Reactome:REACT_90951 "Synthesis of dolichyl-phosphate-glucose, Caenorhabditis elegans"
xref: Reactome:REACT_90956 "Synthesis of dolichyl-phosphate-glucose, Dictyostelium discoideum"
xref: Reactome:REACT_92824 "Synthesis of dolichyl-phosphate-glucose, Sus scrofa"
xref: Reactome:REACT_94061 "Synthesis of dolichyl-phosphate-glucose, Gallus gallus"
xref: Reactome:REACT_95026 "Synthesis of dolichyl-phosphate-glucose, Danio rerio"
xref: Reactome:REACT_95736 "Synthesis of dolichyl-phosphate-glucose, Schizosaccharomyces pombe"
xref: Reactome:REACT_96949 "Synthesis of dolichyl-phosphate-glucose, Bos taurus"
xref: RHEA:15404
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0004582
name: dolichyl-phosphate beta-D-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate." [EC:2.4.1.83]
subset: gosubset_prok
synonym: "dolichol phosphate mannose synthase activity" EXACT [EC:2.4.1.83]
synonym: "dolichol-phosphate mannose synthase activity" EXACT [EC:2.4.1.83]
synonym: "dolichol-phosphate mannosyltransferase activity" EXACT [EC:2.4.1.83]
synonym: "dolichol-phosphate-mannose synthase activity" EXACT []
synonym: "dolichyl mannosyl phosphate synthase activity" EXACT [EC:2.4.1.83]
synonym: "dolichyl phosphate mannosyltransferase activity" EXACT [EC:2.4.1.83]
synonym: "dolichyl-phosphate mannose synthase activity" EXACT [EC:2.4.1.83]
synonym: "dolichyl-phospho-mannose synthase activity" EXACT [EC:2.4.1.83]
synonym: "DPM synthase activity" EXACT []
synonym: "GDP-mannose-dolichol phosphate mannosyltransferase activity" EXACT [EC:2.4.1.83]
synonym: "GDP-mannose:dolichyl-phosphate beta-D-mannosyltransferase activity" EXACT [EC:2.4.1.83]
synonym: "GDPMan:DolP mannosyltransferase activity" EXACT [EC:2.4.1.83]
synonym: "GDPmannose-dolichylmonophosphate mannosyltransferase activity" EXACT [EC:2.4.1.83]
synonym: "GDPmannose:dolichyl-phosphate mannosyltransferase activity" EXACT [EC:2.4.1.83]
synonym: "guanosine diphosphomannose-dolichol phosphate mannosyltransferase activity" EXACT [EC:2.4.1.83]
synonym: "mannosylphosphodolichol synthase activity" EXACT [EC:2.4.1.83]
synonym: "mannosylphosphoryldolichol synthase activity" EXACT [EC:2.4.1.83]
xref: EC:2.4.1.83
xref: MetaCyc:2.4.1.83-RXN
xref: Reactome:REACT_108294 "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose, Bos taurus"
xref: Reactome:REACT_2036 "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose, Homo sapiens"
xref: Reactome:REACT_78249 "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose, Danio rerio"
xref: Reactome:REACT_85479 "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose, Mus musculus"
xref: Reactome:REACT_92201 "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose, Sus scrofa"
xref: Reactome:REACT_95377 "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose, Dictyostelium discoideum"
xref: Reactome:REACT_95543 "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose, Xenopus tropicalis"
xref: Reactome:REACT_97879 "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose, Canis familiaris"
xref: RHEA:21187
is_a: GO:0000030 ! mannosyltransferase activity

[Term]
id: GO:0004583
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an alpha-D-glucosyl residue from dolichyl-phosphate D-glucose into a membrane lipid-linked oligosaccharide." [GOC:mah]
xref: EC:2.4.1.-
xref: MetaCyc:RXN-5472
xref: Reactome:REACT_116026 "Addition of a third glucose to the N-glycan skeleton by Alg10, Saccharomyces cerevisiae"
xref: Reactome:REACT_22158 "Addition of a second glucose to the N-glycan precursor by ALG8, Homo sapiens"
xref: Reactome:REACT_22194 "Addition of the first glucose to the N-glycan precursor by ALG6, Homo sapiens"
xref: Reactome:REACT_22406 "Addition of a third glucose to the N-glycan precursor by an ALG10 homologue, Homo sapiens"
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0004584
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an alpha-D-mannosyl residue from dolichyl-phosphate D-mannose into membrane lipid-linked oligosaccharide." [EC:2.4.1.130]
comment: This term represents a deleted EC activity and is scheduled for obsoletion.
subset: mf_needs_review
synonym: "dolichol phosphomannose-oligosaccharide-lipid mannosyltransferase activity" EXACT [EC:2.4.1.130]
synonym: "dolichyl-phosphate-D-mannose:glycolipid alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.130]
synonym: "oligomannosylsynthase activity" BROAD [EC:2.4.1.130]
xref: EC:2.4.1.130
xref: MetaCyc:2.4.1.130-RXN
is_a: GO:0000030 ! mannosyltransferase activity

[Term]
id: GO:0004585
name: ornithine carbamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: carbamoyl phosphate + L-ornithine = phosphate + L-citrulline." [EC:2.1.3.3]
subset: gosubset_prok
synonym: "carbamoyl-phosphate:L-ornithine carbamoyltransferase activity" EXACT [EC:2.1.3.3]
synonym: "carbamylphosphate-ornithine transcarbamylase activity" EXACT [EC:2.1.3.3]
synonym: "citrulline phosphorylase activity" EXACT [EC:2.1.3.3]
synonym: "L-ornithine carbamoyltransferase activity" EXACT [EC:2.1.3.3]
synonym: "L-ornithine carbamyltransferase activity" EXACT [EC:2.1.3.3]
synonym: "L-ornithine transcarbamylase activity" EXACT [EC:2.1.3.3]
synonym: "ornithine carbamyltransferase activity" EXACT [EC:2.1.3.3]
synonym: "ornithine transcarbamylase activity" EXACT [EC:2.1.3.3]
synonym: "OTC activity" EXACT [EC:2.1.3.3]
synonym: "OTCase activity" EXACT [EC:2.1.3.3]
xref: EC:2.1.3.3
xref: MetaCyc:ORNCARBAMTRANSFER-RXN
xref: Reactome:REACT_102870 "carbamoyl phosphate + ornithine => citrulline + orthophosphate, Arabidopsis thaliana"
xref: Reactome:REACT_105226 "carbamoyl phosphate + ornithine => citrulline + orthophosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_106259 "carbamoyl phosphate + ornithine => citrulline + orthophosphate, Canis familiaris"
xref: Reactome:REACT_108269 "carbamoyl phosphate + ornithine => citrulline + orthophosphate, Mus musculus"
xref: Reactome:REACT_108782 "carbamoyl phosphate + ornithine => citrulline + orthophosphate, Danio rerio"
xref: Reactome:REACT_115561 "carbamoyl phosphate + ornithine => citrulline + orthophosphate, Gallus gallus"
xref: Reactome:REACT_29449 "carbamoyl phosphate + ornithine => citrulline + orthophosphate, Gallus gallus"
xref: Reactome:REACT_30313 "carbamoyl phosphate + ornithine => citrulline + orthophosphate, Rattus norvegicus"
xref: Reactome:REACT_30784 "carbamoyl phosphate + ornithine => citrulline + orthophosphate, Mycobacterium tuberculosis"
xref: Reactome:REACT_32381 "carbamoyl phosphate + ornithine => citrulline + orthophosphate, Xenopus tropicalis"
xref: Reactome:REACT_32826 "carbamoyl phosphate + ornithine => citrulline + orthophosphate, Escherichia coli"
xref: Reactome:REACT_75706 "carbamoyl phosphate + ornithine => citrulline + orthophosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_77338 "carbamoyl phosphate + ornithine => citrulline + orthophosphate, Bos taurus"
xref: Reactome:REACT_78698 "carbamoyl phosphate + ornithine => citrulline + orthophosphate, Staphylococcus aureus N315"
xref: Reactome:REACT_801 "carbamoyl phosphate + ornithine => citrulline + orthophosphate, Homo sapiens"
xref: Reactome:REACT_83411 "carbamoyl phosphate + ornithine => citrulline + orthophosphate, Plasmodium falciparum"
xref: Reactome:REACT_91782 "carbamoyl phosphate + ornithine => citrulline + orthophosphate, Sus scrofa"
xref: Reactome:REACT_95450 "carbamoyl phosphate + ornithine => citrulline + orthophosphate, Taeniopygia guttata"
xref: Reactome:REACT_96735 "carbamoyl phosphate + ornithine => citrulline + orthophosphate, Oryza sativa"
xref: RHEA:19516
is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity
relationship: part_of GO:0006591 ! ornithine metabolic process

[Term]
id: GO:0004586
name: ornithine decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-ornithine + H(+) = CO(2) + putrescine." [EC:4.1.1.17, RHEA:22967]
subset: gosubset_prok
synonym: "L-ornithine carboxy-lyase (putrescine-forming)" EXACT [EC:4.1.1.17]
synonym: "L-ornithine carboxy-lyase activity" NARROW [EC:4.1.1.17]
synonym: "SpeC" RELATED [EC:4.1.1.17]
xref: EC:4.1.1.17
xref: KEGG:R00670
xref: MetaCyc:ORNDECARBOX-RXN
xref: Reactome:REACT_100009 "ornithine => putrescine + CO2, Canis familiaris"
xref: Reactome:REACT_101053 "ornithine => putrescine + CO2, Gallus gallus"
xref: Reactome:REACT_104668 "ornithine => putrescine + CO2, Rattus norvegicus"
xref: Reactome:REACT_105219 "ornithine => putrescine + CO2, Bos taurus"
xref: Reactome:REACT_112162 "ornithine => putrescine + CO2, Staphylococcus aureus N315"
xref: Reactome:REACT_112888 "ornithine => putrescine + CO2, Drosophila melanogaster"
xref: Reactome:REACT_1211 "ornithine => putrescine + CO2, Homo sapiens"
xref: Reactome:REACT_77092 "ornithine => putrescine + CO2, Mus musculus"
xref: Reactome:REACT_80374 "ornithine => putrescine + CO2, Xenopus tropicalis"
xref: Reactome:REACT_84059 "ornithine => putrescine + CO2, Dictyostelium discoideum"
xref: Reactome:REACT_85384 "ornithine => putrescine + CO2, Saccharomyces cerevisiae"
xref: Reactome:REACT_86039 "ornithine => putrescine + CO2, Taeniopygia guttata"
xref: Reactome:REACT_91626 "ornithine => putrescine + CO2, Danio rerio"
xref: Reactome:REACT_98211 "ornithine => putrescine + CO2, Schizosaccharomyces pombe"
xref: RHEA:22967
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004587
name: ornithine-oxo-acid transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid." [EC:2.6.1.13]
subset: gosubset_prok
synonym: "GabT" RELATED [EC:2.6.1.13]
synonym: "L-ornithine 5-aminotransferase activity" EXACT [EC:2.6.1.13]
synonym: "L-ornithine aminotransferase activity" EXACT [EC:2.6.1.13]
synonym: "L-ornithine:2-oxo-acid aminotransferase activity" EXACT [EC:2.6.1.13]
synonym: "L-ornithine:alpha-ketoglutarate delta-aminotransferase activity" EXACT [EC:2.6.1.13]
synonym: "OAT" RELATED [EC:2.6.1.13]
synonym: "ornithine 5-aminotransferase activity" EXACT [EC:2.6.1.13]
synonym: "ornithine aminotransferase activity" EXACT [EC:2.6.1.13]
synonym: "ornithine delta-transaminase activity" EXACT [EC:2.6.1.13]
synonym: "ornithine ketoacid aminotransferase activity" EXACT [EC:2.6.1.13]
synonym: "ornithine transaminase activity" EXACT [EC:2.6.1.13]
synonym: "ornithine--2-oxoacid aminotransferase activity" EXACT [EC:2.6.1.13]
synonym: "ornithine--alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.13]
synonym: "ornithine--keto acid aminotransferase activity" EXACT [EC:2.6.1.13]
synonym: "ornithine--keto acid transaminase activity" EXACT [EC:2.6.1.13]
synonym: "ornithine--ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.13]
synonym: "ornithine--oxo acid aminotransferase activity" EXACT [EC:2.6.1.13]
synonym: "ornithine--oxo-acid transaminase activity" EXACT [EC:2.6.1.13]
synonym: "ornithine-oxo-acid aminotransferase activity" EXACT []
synonym: "ornithine:alpha-oxoglutarate transaminase activity" EXACT [EC:2.6.1.13]
xref: EC:2.6.1.13
xref: MetaCyc:ORNITHINE--OXO-ACID-AMINOTRANSFERASE-RXN
xref: Reactome:REACT_103734 "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT], Canis familiaris"
xref: Reactome:REACT_103755 "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT], Escherichia coli"
xref: Reactome:REACT_104089 "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT], Dictyostelium discoideum"
xref: Reactome:REACT_104115 "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT], Sus scrofa"
xref: Reactome:REACT_105173 "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT], Drosophila melanogaster"
xref: Reactome:REACT_105305 "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT], Xenopus tropicalis"
xref: Reactome:REACT_105934 "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT], Plasmodium falciparum"
xref: Reactome:REACT_107551 "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT], Bos taurus"
xref: Reactome:REACT_108038 "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT], Xenopus tropicalis"
xref: Reactome:REACT_108473 "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT], Dictyostelium discoideum"
xref: Reactome:REACT_108492 "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT], Bos taurus"
xref: Reactome:REACT_109492 "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT], Drosophila melanogaster"
xref: Reactome:REACT_110278 "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT], Canis familiaris"
xref: Reactome:REACT_110724 "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT], Mus musculus"
xref: Reactome:REACT_110765 "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT], Caenorhabditis elegans"
xref: Reactome:REACT_112121 "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT], Staphylococcus aureus N315"
xref: Reactome:REACT_113272 "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT], Staphylococcus aureus N315"
xref: Reactome:REACT_14 "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT], Homo sapiens"
xref: Reactome:REACT_189 "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT], Homo sapiens"
xref: Reactome:REACT_31040 "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT], Gallus gallus"
xref: Reactome:REACT_32966 "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT], Saccharomyces cerevisiae"
xref: Reactome:REACT_33214 "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT], Oryza sativa"
xref: Reactome:REACT_33525 "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT], Mycobacterium tuberculosis"
xref: Reactome:REACT_40426 "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT], Schizosaccharomyces pombe"
xref: Reactome:REACT_77726 "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT], Danio rerio"
xref: Reactome:REACT_79140 "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT], Taeniopygia guttata"
xref: Reactome:REACT_81862 "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT], Caenorhabditis elegans"
xref: Reactome:REACT_82235 "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT], Arabidopsis thaliana"
xref: Reactome:REACT_82330 "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT], Plasmodium falciparum"
xref: Reactome:REACT_83055 "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT], Mycobacterium tuberculosis"
xref: Reactome:REACT_84256 "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT], Danio rerio"
xref: Reactome:REACT_84499 "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT], Schizosaccharomyces pombe"
xref: Reactome:REACT_84818 "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT], Gallus gallus"
xref: Reactome:REACT_86964 "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT], Escherichia coli"
xref: Reactome:REACT_87737 "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT], Arabidopsis thaliana"
xref: Reactome:REACT_91344 "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT], Saccharomyces cerevisiae"
xref: Reactome:REACT_93443 "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT], Taeniopygia guttata"
xref: Reactome:REACT_96745 "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT], Sus scrofa"
xref: Reactome:REACT_96800 "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT], Oryza sativa"
xref: Reactome:REACT_96922 "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT], Mus musculus"
xref: Reactome:REACT_99431 "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT], Rattus norvegicus"
xref: Reactome:REACT_99615 "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT], Rattus norvegicus"
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0004588
name: orotate phosphoribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.10]
subset: gosubset_prok
synonym: "OPRT activity" EXACT [EC:2.4.2.10]
synonym: "OPRTase activity" EXACT [EC:2.4.2.10]
synonym: "orotate phosphoribosyl pyrophosphate transferase activity" EXACT [EC:2.4.2.10]
synonym: "orotic acid phosphoribosyltransferase activity" EXACT [EC:2.4.2.10]
synonym: "orotidine 5'-monophosphate pyrophosphorylase activity" EXACT [EC:2.4.2.10]
synonym: "orotidine monophosphate pyrophosphorylase activity" EXACT [EC:2.4.2.10]
synonym: "orotidine phosphoribosyltransferase activity" EXACT [EC:2.4.2.10]
synonym: "orotidine-5'-phosphate diphosphorylase activity" EXACT [EC:2.4.2.10]
synonym: "orotidine-5'-phosphate pyrophosphorylase activity" EXACT [EC:2.4.2.10]
synonym: "orotidine-5'-phosphate:diphosphate phospho-alpha-D-ribosyl-transferase activity" EXACT [EC:2.4.2.10]
synonym: "orotidylate phosphoribosyltransferase activity" EXACT [EC:2.4.2.10]
synonym: "orotidylate pyrophosphorylase activity" EXACT [EC:2.4.2.10]
synonym: "orotidylic acid phosphorylase activity" EXACT [EC:2.4.2.10]
synonym: "orotidylic acid pyrophosphorylase activity" EXACT [EC:2.4.2.10]
synonym: "orotidylic phosphorylase activity" EXACT [EC:2.4.2.10]
synonym: "orotidylic pyrophosphorylase activity" EXACT [EC:2.4.2.10]
xref: EC:2.4.2.10
xref: MetaCyc:OROPRIBTRANS-RXN
xref: Reactome:REACT_103862 "orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_105415 "orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate, Mus musculus"
xref: Reactome:REACT_107524 "orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_109836 "orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate, Arabidopsis thaliana"
xref: Reactome:REACT_116017 "orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate, Gallus gallus"
xref: Reactome:REACT_29302 "orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate, Taeniopygia guttata"
xref: Reactome:REACT_31825 "orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate, Danio rerio"
xref: Reactome:REACT_32164 "orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate, Bos taurus"
xref: Reactome:REACT_33 "orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate, Homo sapiens"
xref: Reactome:REACT_80131 "orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate, Sus scrofa"
xref: Reactome:REACT_80763 "orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate, Caenorhabditis elegans"
xref: Reactome:REACT_81434 "orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate, Oryza sativa"
xref: Reactome:REACT_81573 "orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_83708 "orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate, Canis familiaris"
xref: Reactome:REACT_85647 "orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate, Mycobacterium tuberculosis"
xref: Reactome:REACT_87670 "orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate, Escherichia coli"
xref: Reactome:REACT_88329 "orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate, Gallus gallus"
xref: Reactome:REACT_89343 "orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate, Plasmodium falciparum"
xref: Reactome:REACT_90104 "orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate, Xenopus tropicalis"
xref: Reactome:REACT_91486 "orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate, Drosophila melanogaster"
xref: Reactome:REACT_98456 "orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate, Rattus norvegicus"
xref: Reactome:REACT_99043 "orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate, Staphylococcus aureus N315"
xref: RHEA:10383
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0004589
name: orotate reductase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-dihydroorotate + NAD(+) = H(+) + NADH + orotate." [EC:1.3.1.14, RHEA:13516]
synonym: "(S)-dihydroorotate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.14]
xref: EC:1.3.1.14
xref: KEGG:R01869
xref: MetaCyc:OROTATE-REDUCTASE-NADH-RXN
xref: RHEA:13516
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004590
name: orotidine-5'-phosphate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(+) + orotidine 5'-phosphate = CO(2) + UMP." [EC:4.1.1.23, RHEA:11599]
subset: gosubset_prok
synonym: "ODCase activity" EXACT [EC:4.1.1.23]
synonym: "OMP decarboxylase activity" EXACT [EC:4.1.1.23]
synonym: "OMP-DC" RELATED [EC:4.1.1.23]
synonym: "OMPdcase activity" EXACT [EC:4.1.1.23]
synonym: "orotate decarboxylase activity" EXACT [EC:4.1.1.23]
synonym: "orotate monophosphate decarboxylase activity" EXACT [EC:4.1.1.23]
synonym: "orotic decarboxylase activity" EXACT [EC:4.1.1.23]
synonym: "orotidine 5'-phosphate decarboxylase activity" EXACT [EC:4.1.1.23]
synonym: "orotidine monophosphate decarboxylase activity" EXACT [EC:4.1.1.23]
synonym: "orotidine phosphate decarboxylase activity" EXACT [EC:4.1.1.23]
synonym: "orotidine-5'-monophosphate decarboxylase activity" EXACT [EC:4.1.1.23]
synonym: "orotidine-5'-phosphate carboxy-lyase (UMP-forming)" EXACT [EC:4.1.1.23]
synonym: "orotidine-5'-phosphate carboxy-lyase activity" EXACT [EC:4.1.1.23]
synonym: "orotidylic acid decarboxylase activity" EXACT [EC:4.1.1.23]
synonym: "orotidylic decarboxylase activity" EXACT [EC:4.1.1.23]
synonym: "orotodylate decarboxylase activity" EXACT [EC:4.1.1.23]
synonym: "UMP synthase activity" EXACT [EC:4.1.1.23]
synonym: "uridine 5'-monophosphate synthase activity" EXACT [EC:4.1.1.23]
xref: EC:4.1.1.23
xref: KEGG:R00965
xref: MetaCyc:OROTPDECARB-RXN
xref: Reactome:REACT_100167 "orotidine 5'-monophosphate => uridine 5'-monophosphate + CO2, Sus scrofa"
xref: Reactome:REACT_100807 "orotidine 5'-monophosphate => uridine 5'-monophosphate + CO2, Staphylococcus aureus N315"
xref: Reactome:REACT_102878 "orotidine 5'-monophosphate => uridine 5'-monophosphate + CO2, Mus musculus"
xref: Reactome:REACT_105495 "orotidine 5'-monophosphate => uridine 5'-monophosphate + CO2, Saccharomyces cerevisiae"
xref: Reactome:REACT_106941 "orotidine 5'-monophosphate => uridine 5'-monophosphate + CO2, Plasmodium falciparum"
xref: Reactome:REACT_108553 "orotidine 5'-monophosphate => uridine 5'-monophosphate + CO2, Xenopus tropicalis"
xref: Reactome:REACT_110007 "orotidine 5'-monophosphate => uridine 5'-monophosphate + CO2, Rattus norvegicus"
xref: Reactome:REACT_110276 "orotidine 5'-monophosphate => uridine 5'-monophosphate + CO2, Mycobacterium tuberculosis"
xref: Reactome:REACT_115671 "orotidine 5'-monophosphate => uridine 5'-monophosphate + CO2, Gallus gallus"
xref: Reactome:REACT_225 "orotidine 5'-monophosphate => uridine 5'-monophosphate + CO2, Homo sapiens"
xref: Reactome:REACT_28167 "orotidine 5'-monophosphate => uridine 5'-monophosphate + CO2, Gallus gallus"
xref: Reactome:REACT_31689 "orotidine 5'-monophosphate => uridine 5'-monophosphate + CO2, Caenorhabditis elegans"
xref: Reactome:REACT_34349 "orotidine 5'-monophosphate => uridine 5'-monophosphate + CO2, Arabidopsis thaliana"
xref: Reactome:REACT_80816 "orotidine 5'-monophosphate => uridine 5'-monophosphate + CO2, Canis familiaris"
xref: Reactome:REACT_82540 "orotidine 5'-monophosphate => uridine 5'-monophosphate + CO2, Oryza sativa"
xref: Reactome:REACT_83379 "orotidine 5'-monophosphate => uridine 5'-monophosphate + CO2, Schizosaccharomyces pombe"
xref: Reactome:REACT_83718 "orotidine 5'-monophosphate => uridine 5'-monophosphate + CO2, Taeniopygia guttata"
xref: Reactome:REACT_85504 "orotidine 5'-monophosphate => uridine 5'-monophosphate + CO2, Escherichia coli"
xref: Reactome:REACT_86018 "orotidine 5'-monophosphate => uridine 5'-monophosphate + CO2, Danio rerio"
xref: Reactome:REACT_86723 "orotidine 5'-monophosphate => uridine 5'-monophosphate + CO2, Dictyostelium discoideum"
xref: Reactome:REACT_91989 "orotidine 5'-monophosphate => uridine 5'-monophosphate + CO2, Drosophila melanogaster"
xref: Reactome:REACT_93464 "orotidine 5'-monophosphate => uridine 5'-monophosphate + CO2, Bos taurus"
xref: RHEA:11599
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004591
name: oxoglutarate dehydrogenase (succinyl-transferring) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + lipoamide = S-succinyldihydrolipoamide + CO2." [EC:1.2.4.2]
subset: gosubset_prok
synonym: "2-ketoglutarate dehydrogenase activity" EXACT [EC:1.2.4.2]
synonym: "2-oxoglutarate dehydrogenase activity" EXACT [EC:1.2.4.2]
synonym: "2-oxoglutarate: lipoate oxidoreductase activity" EXACT [EC:1.2.4.2]
synonym: "2-oxoglutarate:dihydrolipoyllysine-residue succinyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating)" EXACT [EC:1.2.4.2]
synonym: "2-oxoglutarate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-succinylating) activity" EXACT [EC:1.2.4.2]
synonym: "AKGDH activity" EXACT [EC:1.2.4.2]
synonym: "alpha-ketoglutarate dehydrogenase activity" EXACT [EC:1.2.4.2]
synonym: "alpha-ketoglutaric acid dehydrogenase activity" EXACT [EC:1.2.4.2]
synonym: "alpha-ketoglutaric dehydrogenase activity" EXACT [EC:1.2.4.2]
synonym: "alpha-oxoglutarate dehydrogenase activity" EXACT [EC:1.2.4.2]
synonym: "ketoglutaric dehydrogenase activity" EXACT [EC:1.2.4.2]
synonym: "OGDC activity" EXACT [EC:1.2.4.2]
synonym: "oxoglutarate decarboxylase activity" EXACT [EC:1.2.4.2]
synonym: "oxoglutarate dehydrogenase (lipoamide) activity" EXACT []
synonym: "oxoglutarate dehydrogenase activity" EXACT [EC:1.2.4.2]
xref: EC:1.2.4.2
xref: MetaCyc:2OXOGLUTDECARB-RXN
is_a: GO:0016624 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor

[Term]
id: GO:0004592
name: pantoate-beta-alanine ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate." [EC:6.3.2.1]
subset: gosubset_prok
synonym: "(R)-pantoate:beta-alanine ligase (AMP-forming)" EXACT [EC:6.3.2.1]
synonym: "D-pantoate:beta-alanine ligase (AMP-forming)" EXACT [EC:6.3.2.1]
synonym: "pantoate-activating enzyme activity" RELATED [EC:6.3.2.1]
synonym: "pantoic-activating enzyme activity" RELATED [EC:6.3.2.1]
synonym: "pantothenate synthetase activity" EXACT [EC:6.3.2.1]
xref: EC:6.3.2.1
xref: MetaCyc:PANTOATE-BETA-ALANINE-LIG-RXN
xref: RHEA:10915
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0004593
name: pantothenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-pantothenate + H(2)O = (R)-pantoate + beta-alanine." [EC:3.5.1.22, RHEA:12451]
synonym: "(R)-pantothenate amidohydrolase activity" EXACT [EC:3.5.1.22]
synonym: "pantothenate amidohydrolase activity" EXACT [EC:3.5.1.22]
synonym: "pantothenate hydrolase activity" EXACT [EC:3.5.1.22]
xref: EC:3.5.1.22
xref: KEGG:R02474
xref: MetaCyc:PANTOTHENASE-RXN
xref: RHEA:12451
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0004594
name: pantothenate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate." [EC:2.7.1.33]
subset: gosubset_prok
synonym: "ATP:(R)-pantothenate 4'-phosphotransferase activity" EXACT [EC:2.7.1.33]
synonym: "ATP:pantothenate 4'-phosphotransferase activity" EXACT [EC:2.7.1.33]
synonym: "D-pantothenate kinase activity" EXACT [EC:2.7.1.33]
synonym: "pantothenate kinase (phosphorylating) activity" EXACT [EC:2.7.1.33]
synonym: "pantothenic acid kinase activity" EXACT [EC:2.7.1.33]
xref: EC:2.7.1.33
xref: MetaCyc:PANTOTHENATE-KIN-RXN
xref: Reactome:REACT_100199 "Pantothenate is phosphorylated [PANK2], Xenopus tropicalis"
xref: Reactome:REACT_102890 "Pantothenate is phosphorylated [PANK2], Bos taurus"
xref: Reactome:REACT_103860 "Pantothenate is phosphorylated [PANK1;3;4], Danio rerio"
xref: Reactome:REACT_106034 "Pantothenate is phosphorylated [PANK2], Taeniopygia guttata"
xref: Reactome:REACT_106911 "Pantothenate is phosphorylated [PANK2], Staphylococcus aureus N315"
xref: Reactome:REACT_109193 "Pantothenate is phosphorylated [PANK2], Rattus norvegicus"
xref: Reactome:REACT_11129 "Pantothenate is phosphorylated [PANK1;3;4], Homo sapiens"
xref: Reactome:REACT_11197 "Pantothenate is phosphorylated [PANK2], Homo sapiens"
xref: Reactome:REACT_112157 "Pantothenate is phosphorylated [PANK1;3;4], Plasmodium falciparum"
xref: Reactome:REACT_112376 "Pantothenate is phosphorylated [PANK2], Plasmodium falciparum"
xref: Reactome:REACT_113306 "Pantothenate is phosphorylated [PANK1;3;4], Xenopus tropicalis"
xref: Reactome:REACT_33195 "Pantothenate is phosphorylated [PANK1;3;4], Canis familiaris"
xref: Reactome:REACT_34346 "Pantothenate is phosphorylated [PANK1;3;4], Staphylococcus aureus N315"
xref: Reactome:REACT_34667 "Pantothenate is phosphorylated [PANK1;3;4], Taeniopygia guttata"
xref: Reactome:REACT_77458 "Pantothenate is phosphorylated [PANK2], Mus musculus"
xref: Reactome:REACT_78875 "Pantothenate is phosphorylated [PANK1;3;4], Sus scrofa"
xref: Reactome:REACT_80667 "Pantothenate is phosphorylated [PANK2], Danio rerio"
xref: Reactome:REACT_81648 "Pantothenate is phosphorylated [PANK2], Sus scrofa"
xref: Reactome:REACT_84596 "Pantothenate is phosphorylated [PANK2], Canis familiaris"
xref: Reactome:REACT_85838 "Pantothenate is phosphorylated [PANK1;3;4], Gallus gallus"
xref: Reactome:REACT_86443 "Pantothenate is phosphorylated [PANK1;3;4], Mus musculus"
xref: Reactome:REACT_86843 "Pantothenate is phosphorylated [PANK1;3;4], Bos taurus"
xref: Reactome:REACT_90072 "Pantothenate is phosphorylated [PANK1;3;4], Drosophila melanogaster"
xref: Reactome:REACT_93775 "Pantothenate is phosphorylated [PANK2], Drosophila melanogaster"
xref: Reactome:REACT_94823 "Pantothenate is phosphorylated [PANK2], Gallus gallus"
xref: Reactome:REACT_96043 "Pantothenate is phosphorylated [PANK1;3;4], Rattus norvegicus"
xref: RHEA:16376
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0004595
name: pantetheine-phosphate adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + pantetheine 4'-phosphate = 3'-dephospho-CoA + diphosphate." [EC:2.7.7.3, RHEA:19804]
subset: gosubset_prok
synonym: "3'-dephospho-CoA pyrophosphorylase activity" EXACT [EC:2.7.7.3]
synonym: "ATP:pantetheine-4'-phosphate adenylyltransferase activity" EXACT [EC:2.7.7.3]
synonym: "ATP:pantetheine-phosphate adenylyltransferase activity" EXACT []
synonym: "dephospho-CoA diphosphorylase activity" EXACT [EC:2.7.7.3]
synonym: "dephospho-CoA pyrophosphorylase activity" EXACT [EC:2.7.7.3]
synonym: "dephospho-coenzyme A pyrophosphorylase activity" EXACT [EC:2.7.7.3]
synonym: "pantetheine phosphate adenylyltransferase activity" EXACT [EC:2.7.7.3]
synonym: "phosphopantetheine adenylyltransferase activity" EXACT []
synonym: "PPAT activity" EXACT [EC:2.7.7.3]
xref: EC:2.7.7.3
xref: KEGG:R03035
xref: MetaCyc:PANTEPADENYLYLTRAN-RXN
xref: Reactome:REACT_101882 "Adenylation of phosphopantetheine, Mus musculus"
xref: Reactome:REACT_107996 "Adenylation of phosphopantetheine, Dictyostelium discoideum"
xref: Reactome:REACT_110459 "Adenylation of phosphopantetheine, Canis familiaris"
xref: Reactome:REACT_11222 "Adenylation of phosphopantetheine, Homo sapiens"
xref: Reactome:REACT_113938 "Adenylation of phosphopantetheine, Plasmodium falciparum"
xref: Reactome:REACT_30920 "Adenylation of phosphopantetheine, Caenorhabditis elegans"
xref: Reactome:REACT_31370 "Adenylation of phosphopantetheine, Xenopus tropicalis"
xref: Reactome:REACT_34054 "Adenylation of phosphopantetheine, Danio rerio"
xref: Reactome:REACT_78737 "Adenylation of phosphopantetheine, Rattus norvegicus"
xref: Reactome:REACT_81268 "Adenylation of phosphopantetheine, Sus scrofa"
xref: Reactome:REACT_84118 "Adenylation of phosphopantetheine, Taeniopygia guttata"
xref: Reactome:REACT_88574 "Adenylation of phosphopantetheine, Drosophila melanogaster"
xref: Reactome:REACT_92290 "Adenylation of phosphopantetheine, Escherichia coli"
xref: RHEA:19804
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0004596
name: peptide alpha-N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + peptide = CoA + N-alpha-acetylpeptide. This reaction is the acetylation of the N-terminal amino acid residue of a peptide or protein." [EC:2.3.1.88, GOC:mah]
subset: gosubset_prok
synonym: "acetyl-CoA:peptide alpha-N-acetyltransferase activity" EXACT [EC:2.3.1.88]
synonym: "acetyl-CoA:peptide nalpha-acetyltransferase activity" EXACT [EC:2.3.1.88]
synonym: "amino-terminal amino acid-acetylating enzyme activity" RELATED [EC:2.3.1.88]
synonym: "beta-endorphin acetyltransferase activity" NARROW [EC:2.3.1.88]
synonym: "N(alpha)-acetyltransferase activity" RELATED [EC:2.3.1.88]
synonym: "nalpha-acetyltransferase activity" EXACT [EC:2.3.1.88]
synonym: "NAT activity" RELATED [EC:2.3.1.88]
synonym: "peptide acetyltransferase activity" RELATED [EC:2.3.1.88]
synonym: "protein N-terminal acetyltransferase activity" EXACT [EC:2.3.1.88]
xref: EC:2.3.1.88
xref: MetaCyc:PEPTIDE-ALPHA-N-ACETYLTRANSFERASE-RXN
is_a: GO:0034212 ! peptide N-acetyltransferase activity

[Term]
id: GO:0004597
name: peptide-aspartate beta-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: peptide L-aspartate + 2-oxoglutarate + O2 = peptide 3-hydroxy-L-aspartate + succinate + CO2." [EC:1.14.11.16]
subset: gosubset_prok
synonym: "aspartate beta-hydroxylase activity" EXACT [EC:1.14.11.16]
synonym: "aspartyl/asparaginyl beta-hydroxylase activity" RELATED [EC:1.14.11.16]
synonym: "aspartylpeptide beta-dioxygenase activity" EXACT [EC:1.14.11.16]
synonym: "peptide-L-aspartate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.11.16]
xref: EC:1.14.11.16
xref: MetaCyc:PEPTIDE-ASPARTATE-BETA-DIOXYGENASE-RXN
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0004598
name: peptidylamidoglycolate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: peptidylamidoglycolate = peptidyl amide + glyoxylate." [EC:4.3.2.5]
synonym: "alpha-hydroxyglycine amidating dealkylase activity" EXACT [EC:4.3.2.5]
synonym: "HGAD" RELATED [EC:4.3.2.5]
synonym: "PAL" RELATED [EC:4.3.2.5]
synonym: "peptidyl-alpha-hydroxyglycine alpha-amidating lyase activity" EXACT [EC:4.3.2.5]
synonym: "peptidylamidoglycolate peptidylamide-lyase (glyoxylate-forming)" EXACT [EC:4.3.2.5]
synonym: "peptidylamidoglycolate peptidylamide-lyase activity" EXACT [EC:4.3.2.5]
synonym: "PGL" RELATED [EC:4.3.2.5]
xref: EC:4.3.2.5
xref: MetaCyc:PEPTIDYLAMIDOGLYCOLATE-LYASE-RXN
is_a: GO:0016842 ! amidine-lyase activity

[Term]
id: GO:0004600
name: obsolete cyclophilin
namespace: molecular_function
def: "OBSOLETE. A protein to which cyclosporin A (an immunosuppressant) binds. Possesses peptidyl-prolyl isomerase activity." [EC:5.2.1.8, ISBN:0198506732]
comment: This term was made obsolete because it does not represent a molecular function.
synonym: "cyclophilin" EXACT []
is_obsolete: true
consider: GO:0003755
consider: GO:0016018

[Term]
id: GO:0004601
name: peroxidase activity
namespace: molecular_function
alt_id: GO:0016685
alt_id: GO:0016686
alt_id: GO:0016687
alt_id: GO:0016693
def: "Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.7]
subset: gosubset_prok
synonym: "bacterial catalase-peroxidase activity" NARROW []
synonym: "donor:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.7]
synonym: "eosinophil peroxidase activity" NARROW []
synonym: "extensin peroxidase" NARROW [EC:1.11.1.7]
synonym: "guaiacol peroxidase" NARROW [EC:1.11.1.7]
synonym: "heme peroxidase" NARROW [EC:1.11.1.7]
synonym: "horseradish peroxidase (HRP)" NARROW [EC:1.11.1.7]
synonym: "japanese radish peroxidase" NARROW [EC:1.11.1.7]
synonym: "lactoperoxidase activity" NARROW []
synonym: "MPO" RELATED [EC:1.11.1.7]
synonym: "myeloperoxidase activity" NARROW []
synonym: "oxyperoxidase activity" EXACT [EC:1.11.1.7]
synonym: "peroxidase reaction" EXACT []
synonym: "protoheme peroxidase" NARROW [EC:1.11.1.7]
synonym: "pyrocatechol peroxidase" NARROW [EC:1.11.1.7]
synonym: "scopoletin peroxidase" NARROW [EC:1.11.1.7]
synonym: "secretory plant peroxidase activity" NARROW []
synonym: "thiocyanate peroxidase" NARROW [EC:1.11.1.7]
synonym: "verdoperoxidase" NARROW [EC:1.11.1.7]
xref: EC:1.11.1.7
xref: KEGG:R03532
xref: MetaCyc:PEROXID-RXN
xref: Reactome:REACT_100373 "Peroxidative reduction of PGG2 to PGH2, Bos taurus"
xref: Reactome:REACT_101046 "DIT and MIT combine to form triiodothyronine, Sus scrofa"
xref: Reactome:REACT_101589 "Tyrosine is diiodinated, Rattus norvegicus"
xref: Reactome:REACT_102144 "Peroxidative reduction of PGG2 to PGH2, Taeniopygia guttata"
xref: Reactome:REACT_104442 "Tyrosine is diiodinated, Canis familiaris"
xref: Reactome:REACT_105725 "Peroxidative reduction of PGG2 to PGH2, Mus musculus"
xref: Reactome:REACT_106670 "Tyrosine is diiodinated, Mus musculus"
xref: Reactome:REACT_108020 "Iodide is organified, Rattus norvegicus"
xref: Reactome:REACT_108229 "Peroxidative reduction of PGG2 to PGH2, Gallus gallus"
xref: Reactome:REACT_111983 "Tyrosine is monoiodinated, Dictyostelium discoideum"
xref: Reactome:REACT_112213 "Iodide is organified, Danio rerio"
xref: Reactome:REACT_112249 "Tyrosine is diiodinated, Dictyostelium discoideum"
xref: Reactome:REACT_113235 "Tyrosine is diiodinated, Danio rerio"
xref: Reactome:REACT_113904 "DIT and MIT combine to form triiodothyronine, Dictyostelium discoideum"
xref: Reactome:REACT_113988 "Two DITs combine to form thyroxine, Dictyostelium discoideum"
xref: Reactome:REACT_114100 "Iodide is organified, Dictyostelium discoideum"
xref: Reactome:REACT_114351 "Tyrosine is monoiodinated, Danio rerio"
xref: Reactome:REACT_114796 "DIT and MIT combine to form triiodothyronine, Danio rerio"
xref: Reactome:REACT_115058 "Two DITs combine to form thyroxine, Danio rerio"
xref: Reactome:REACT_15360 "DIT and MIT combine to form triiodothyronine, Homo sapiens"
xref: Reactome:REACT_15430 "Two DITs combine to form thyroxine, Homo sapiens"
xref: Reactome:REACT_15445 "Tyrosine is monoiodinated, Homo sapiens"
xref: Reactome:REACT_15455 "Tyrosine is diiodinated, Homo sapiens"
xref: Reactome:REACT_15539 "Iodide is organified, Homo sapiens"
xref: Reactome:REACT_28086 "Tyrosine is monoiodinated, Canis familiaris"
xref: Reactome:REACT_28372 "Two DITs combine to form thyroxine, Taeniopygia guttata"
xref: Reactome:REACT_29881 "Peroxidative reduction of PGG2 to PGH2, Canis familiaris"
xref: Reactome:REACT_30736 "Two DITs combine to form thyroxine, Rattus norvegicus"
xref: Reactome:REACT_30826 "DIT and MIT combine to form triiodothyronine, Rattus norvegicus"
xref: Reactome:REACT_31807 "Peroxidative reduction of PGG2 to PGH2, Sus scrofa"
xref: Reactome:REACT_32140 "Peroxidative reduction of PGG2 to PGH2, Xenopus tropicalis"
xref: Reactome:REACT_32854 "Peroxidative reduction of PGG2 to PGH2, Danio rerio"
xref: Reactome:REACT_33827 "Two DITs combine to form thyroxine, Sus scrofa"
xref: Reactome:REACT_33837 "Tyrosine is monoiodinated, Taeniopygia guttata"
xref: Reactome:REACT_76985 "Iodide is organified, Mus musculus"
xref: Reactome:REACT_78273 "DIT and MIT combine to form triiodothyronine, Xenopus tropicalis"
xref: Reactome:REACT_78937 "Iodide is organified, Gallus gallus"
xref: Reactome:REACT_79084 "Tyrosine is diiodinated, Xenopus tropicalis"
xref: Reactome:REACT_79114 "DIT and MIT combine to form triiodothyronine, Canis familiaris"
xref: Reactome:REACT_810 "Peroxidative reduction of PGG2 to PGH2, Homo sapiens"
xref: Reactome:REACT_81922 "Two DITs combine to form thyroxine, Canis familiaris"
xref: Reactome:REACT_82000 "Tyrosine is monoiodinated, Rattus norvegicus"
xref: Reactome:REACT_85332 "Two DITs combine to form thyroxine, Mus musculus"
xref: Reactome:REACT_85339 "Iodide is organified, Xenopus tropicalis"
xref: Reactome:REACT_85899 "Tyrosine is diiodinated, Taeniopygia guttata"
xref: Reactome:REACT_86613 "Tyrosine is monoiodinated, Mus musculus"
xref: Reactome:REACT_87489 "Iodide is organified, Canis familiaris"
xref: Reactome:REACT_87731 "Tyrosine is diiodinated, Gallus gallus"
xref: Reactome:REACT_88313 "Iodide is organified, Taeniopygia guttata"
xref: Reactome:REACT_90277 "Two DITs combine to form thyroxine, Gallus gallus"
xref: Reactome:REACT_90987 "Tyrosine is diiodinated, Sus scrofa"
xref: Reactome:REACT_91636 "Tyrosine is monoiodinated, Gallus gallus"
xref: Reactome:REACT_91853 "Tyrosine is monoiodinated, Xenopus tropicalis"
xref: Reactome:REACT_92128 "DIT and MIT combine to form triiodothyronine, Mus musculus"
xref: Reactome:REACT_94963 "Tyrosine is monoiodinated, Sus scrofa"
xref: Reactome:REACT_96008 "DIT and MIT combine to form triiodothyronine, Taeniopygia guttata"
xref: Reactome:REACT_97146 "Iodide is organified, Sus scrofa"
xref: Reactome:REACT_97248 "Two DITs combine to form thyroxine, Xenopus tropicalis"
xref: Reactome:REACT_97539 "Peroxidative reduction of PGG2 to PGH2, Rattus norvegicus"
xref: Reactome:REACT_98848 "DIT and MIT combine to form triiodothyronine, Gallus gallus"
xref: RHEA:23637
is_a: GO:0016209 ! antioxidant activity
is_a: GO:0016684 ! oxidoreductase activity, acting on peroxide as acceptor

[Term]
id: GO:0004602
name: glutathione peroxidase activity
namespace: molecular_function
alt_id: GO:0016224
def: "Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O." [EC:1.11.1.9]
subset: gosubset_prok
synonym: "glutathione:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.9]
synonym: "GSH peroxidase activity" EXACT [EC:1.11.1.9]
synonym: "non-selenium glutathione peroxidase activity" NARROW []
synonym: "reduced glutathione peroxidase activity" EXACT [EC:1.11.1.9]
synonym: "selenium-glutathione peroxidase activity" EXACT [EC:1.11.1.9]
xref: EC:1.11.1.9
xref: MetaCyc:GLUTATHIONE-PEROXIDASE-RXN
xref: Reactome:REACT_106570 "2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O, Mus musculus"
xref: Reactome:REACT_112920 "2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O, Danio rerio"
xref: Reactome:REACT_113573 "2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O, Plasmodium falciparum"
xref: Reactome:REACT_114008 "2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O, Escherichia coli"
xref: Reactome:REACT_2037 "2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O, Homo sapiens"
xref: Reactome:REACT_81396 "2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O, Taeniopygia guttata"
xref: Reactome:REACT_96265 "2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O, Canis familiaris"
xref: RHEA:16836
is_a: GO:0004601 ! peroxidase activity

[Term]
id: GO:0004603
name: phenylethanolamine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine." [EC:2.1.1.28]
synonym: "noradrenalin N-methyltransferase activity" EXACT [EC:2.1.1.28]
synonym: "noradrenaline N-methyltransferase activity" RELATED [EC:2.1.1.28]
synonym: "norepinephrine methyltransferase activity" EXACT [EC:2.1.1.28]
synonym: "norepinephrine N-methyltransferase activity" EXACT [EC:2.1.1.28]
synonym: "phenethanolamine methyltransferase activity" EXACT [EC:2.1.1.28]
synonym: "phenethanolamine N-methyltransferase activity" EXACT [EC:2.1.1.28]
synonym: "S-adenosyl-L-methionine:phenylethanolamine N-methyltransferase activity" EXACT [EC:2.1.1.28]
xref: EC:2.1.1.28
xref: MetaCyc:2.1.1.28-RXN
xref: Reactome:REACT_102352 "Noradrenaline is converted to adrenaline, Canis familiaris"
xref: Reactome:REACT_104159 "Noradrenaline is converted to adrenaline, Taeniopygia guttata"
xref: Reactome:REACT_105227 "Noradrenaline is converted to adrenaline, Bos taurus"
xref: Reactome:REACT_15442 "Noradrenaline is converted to adrenaline, Homo sapiens"
xref: Reactome:REACT_33808 "Noradrenaline is converted to adrenaline, Xenopus tropicalis"
xref: Reactome:REACT_92425 "Noradrenaline is converted to adrenaline, Sus scrofa"
xref: Reactome:REACT_96988 "Noradrenaline is converted to adrenaline, Mus musculus"
xref: Reactome:REACT_99432 "Noradrenaline is converted to adrenaline, Caenorhabditis elegans"
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0004604
name: phosphoadenylyl-sulfate reductase (thioredoxin) activity
namespace: molecular_function
def: "Catalysis of the reaction: adenosine 3',5'-diphosphate + H(+) + sulfite + thioredoxin disulfide = 3'-phospho-5'-adenylyl sulfate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin; 3'-phosphoadenosine 5'-phosphosulfate is also known as PAPS." [EC:1.8.4.8, RHEA:11727]
subset: gosubset_prok
synonym: "3'-phosphoadenylylsulfate reductase activity" EXACT [EC:1.8.4.8]
synonym: "adenosine 3',5'-bisphosphate,sulfite:oxidized-thioredoxin oxidoreductase (3'-phosphoadenosine-5'-phosphosulfate-forming)" EXACT [EC:1.8.4.8]
synonym: "adenosine 3',5'-bisphosphate,sulfite:thioredoxin-disulfide oxidoreductase (3'-phosphoadenosine-5'-phosphosulfate-forming)" EXACT [EC:1.8.4.8]
synonym: "PAdoPS reductase activity" EXACT [EC:1.8.4.8]
synonym: "PAPS reductase activity" EXACT [EC:1.8.4.8]
synonym: "PAPS reductase, thioredoxin-dependent activity" EXACT [EC:1.8.4.8]
synonym: "PAPS sulfotransferase activity" EXACT [EC:1.8.4.8]
synonym: "phosphoadenosine-phosphosulfate reductase activity" EXACT [EC:1.8.4.8]
synonym: "phosphoadenylyl-sulphate reductase (thioredoxin) activity" EXACT []
synonym: "thioredoxin:3'-phospho-adenylylsulfate reductase activity" EXACT [EC:1.8.4.8]
synonym: "thioredoxin:adenosine 3'-phosphate 5'-phosphosulfate reductase activity" EXACT [EC:1.8.4.8]
xref: EC:1.8.4.8
xref: KEGG:R02021
xref: MetaCyc:1.8.4.8-RXN
xref: Reactome:REACT_27147 "sulfite results from reduction of APS, Mycobacterium tuberculosis"
xref: RHEA:11727
is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor

[Term]
id: GO:0004605
name: phosphatidate cytidylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CTP + phosphatidate = diphosphate + CDP-diacylglycerol." [EC:2.7.7.41]
subset: gosubset_prok
synonym: "CDP diglyceride pyrophosphorylase activity" EXACT [EC:2.7.7.41]
synonym: "CDP-DG" RELATED [EC:2.7.7.41]
synonym: "CDP-diacylglyceride synthetase activity" EXACT [EC:2.7.7.41]
synonym: "CDP-diacylglycerol synthase activity" EXACT []
synonym: "CDP-diglyceride diphosphorylase activity" EXACT []
synonym: "CDP-diglyceride pyrophosphorylase activity" EXACT []
synonym: "CDP-diglyceride synthase activity" EXACT []
synonym: "CDP-diglyceride synthetase activity" EXACT [EC:2.7.7.41]
synonym: "CTP-diacylglycerol synthetase activity" EXACT [EC:2.7.7.41]
synonym: "CTP:1,2-diacylglycerophosphate-cytidyl transferase activity" EXACT [EC:2.7.7.41]
synonym: "CTP:phosphatidate cytidylyltransferase activity" EXACT [EC:2.7.7.41]
synonym: "cytidine diphosphoglyceride pyrophosphorylase activity" EXACT [EC:2.7.7.41]
synonym: "DAG synthetase activity" EXACT [EC:2.7.7.41]
synonym: "phosphatidate cytidyltransferase activity" EXACT [EC:2.7.7.41]
synonym: "phosphatidic acid cytidylyltransferase activity" EXACT [EC:2.7.7.41]
xref: EC:2.7.7.41
xref: MetaCyc:CDPDIGLYSYN-RXN
xref: RHEA:16232
is_a: GO:0070567 ! cytidylyltransferase activity

[Term]
id: GO:0004607
name: phosphatidylcholine-sterol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphatidylcholine + a sterol = a sterol ester + 1-acylglycerophosphocholine." [EC:2.3.1.43]
subset: gosubset_prok
synonym: "LCAT (lecithin-cholesterol acyltransferase)" RELATED [EC:2.3.1.43]
synonym: "LCAT activity" EXACT [EC:2.3.1.43]
synonym: "lecithin--cholesterol acyltransferase activity" EXACT [EC:2.3.1.43]
synonym: "lecithin:cholesterol acyltransferase activity" EXACT [EC:2.3.1.43]
synonym: "phosphatidylcholine:sterol O-acyltransferase activity" EXACT [EC:2.3.1.43]
synonym: "phospholipid--cholesterol acyltransferase activity" EXACT [EC:2.3.1.43]
xref: EC:2.3.1.43
xref: MetaCyc:2.3.1.43-RXN
xref: Reactome:REACT_100113 "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin), Plasmodium falciparum"
xref: Reactome:REACT_101699 "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin), Rattus norvegicus"
xref: Reactome:REACT_101842 "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin), Arabidopsis thaliana"
xref: Reactome:REACT_102543 "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin), Canis familiaris"
xref: Reactome:REACT_106466 "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin), Bos taurus"
xref: Reactome:REACT_13506 "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin), Homo sapiens"
xref: Reactome:REACT_30729 "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin), Caenorhabditis elegans"
xref: Reactome:REACT_32117 "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin), Taeniopygia guttata"
xref: Reactome:REACT_80246 "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin), Mus musculus"
xref: Reactome:REACT_87291 "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin), Oryza sativa"
xref: Reactome:REACT_93654 "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin), Drosophila melanogaster"
xref: Reactome:REACT_96222 "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin), Danio rerio"
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0004608
name: phosphatidylethanolamine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + H(+) + phosphatidyl-N-methylethanolamine." [EC:2.1.1.17, RHEA:11167]
subset: gosubset_prok
synonym: "lipid methyl transferase activity" EXACT [EC:2.1.1.17]
synonym: "LMTase activity" EXACT [EC:2.1.1.17]
synonym: "PEMT" RELATED [EC:2.1.1.17]
synonym: "phosphatidylethanolamine methyltransferase activity" EXACT [EC:2.1.1.17]
synonym: "phosphatidylethanolamine-N-methylase activity" EXACT [EC:2.1.1.17]
synonym: "phosphatidylethanolamine-S-adenosylmethionine methyltransferase activity" EXACT [EC:2.1.1.17]
synonym: "S-adenosyl-L-methionine:phosphatidylethanolamine N-methyltransferase activity" EXACT [EC:2.1.1.17]
xref: EC:2.1.1.17
xref: KEGG:R02056
xref: MetaCyc:2.1.1.17-RXN
xref: RHEA:11167
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0004609
name: phosphatidylserine decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(+) + phosphatidyl-L-serine = CO(2) + phosphatidylethanolamine." [EC:4.1.1.65, RHEA:20831]
subset: gosubset_prok
synonym: "phosphatidyl-L-serine carboxy-lyase (phosphatidylethanolamine-forming)" EXACT [EC:4.1.1.65]
synonym: "phosphatidyl-L-serine carboxy-lyase activity" EXACT [EC:4.1.1.65]
synonym: "PS decarboxylase activity" EXACT [EC:4.1.1.65]
xref: EC:4.1.1.65
xref: KEGG:R02055
xref: MetaCyc:PHOSPHASERDECARB-RXN
xref: RHEA:20831
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004610
name: phosphoacetylglucosamine mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate." [EC:5.4.2.3, RHEA:23807]
subset: gosubset_prok
synonym: "acetylaminodeoxyglucose phosphomutase activity" EXACT [EC:5.4.2.3]
synonym: "acetylglucosamine phosphomutase activity" EXACT [EC:5.4.2.3]
synonym: "N-acetyl-alpha-D-glucosamine 1,6-phosphomutase activity" EXACT [EC:5.4.2.3]
synonym: "N-acetyl-D-glucosamine 1,6-phosphomutase activity" EXACT [EC:5.4.2.3]
synonym: "N-acetylglucosamine-phosphate mutase activity" EXACT [EC:5.4.2.3]
synonym: "phospho-N-acetylglucosamine mutase activity" EXACT [EC:5.4.2.3]
xref: EC:5.4.2.3
xref: KEGG:R08193
xref: MetaCyc:PHOSACETYLGLUCOSAMINEMUT-RXN
xref: Reactome:REACT_22269 "Isomerization of GlcNAc6P to GlcNAc1P, Homo sapiens"
xref: RHEA:23807
is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases

[Term]
id: GO:0004611
name: phosphoenolpyruvate carboxykinase activity
namespace: molecular_function
def: "Catalysis of the reaction: source of phosphate + oxaloacetate = phosphoenolpyruvate + CO2 + other reaction products." [EC:4.1.1.-]
subset: gosubset_prok
synonym: "PEP carboxykinase activity" EXACT [EC:4.1.1.-]
synonym: "PEPCK activity" EXACT [EC:4.1.1.-]
synonym: "phosphopyruvate carboxylase activity" EXACT [EC:4.1.1.-]
xref: EC:4.1.1.-
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004612
name: phosphoenolpyruvate carboxykinase (ATP) activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + oxaloacetate = ADP + CO(2) + H(+) + phosphoenolpyruvate." [EC:4.1.1.49, RHEA:18620]
subset: gosubset_prok
synonym: "ATP:oxaloacetate carboxy-lyase (transphosphorylating)" EXACT [EC:4.1.1.49]
synonym: "ATP:oxaloacetate carboxy-lyase (transphosphorylating; phosphoenolpyruvate-forming)" EXACT [EC:4.1.1.49]
synonym: "PEPCK (ATP)" RELATED [EC:4.1.1.49]
synonym: "PEPK" RELATED [EC:4.1.1.49]
synonym: "phosphoenolpyruvate carboxylase (ATP)" EXACT [EC:4.1.1.49]
synonym: "phosphoenolpyruvic carboxykinase" BROAD [EC:4.1.1.49]
synonym: "phosphopyruvate carboxykinase" BROAD [EC:4.1.1.49]
synonym: "phosphopyruvate carboxykinase (adenosine triphosphate)" EXACT [EC:4.1.1.49]
synonym: "phosphopyruvate carboxylase (ATP)" EXACT [EC:4.1.1.49]
xref: EC:4.1.1.49
xref: KEGG:R00341
xref: MetaCyc:PEPCARBOXYKIN-RXN
xref: RHEA:18620
is_a: GO:0004611 ! phosphoenolpyruvate carboxykinase activity

[Term]
id: GO:0004613
name: phosphoenolpyruvate carboxykinase (GTP) activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2." [EC:4.1.1.32]
subset: gosubset_prok
synonym: "GTP:oxaloacetate carboxy-lyase (adding GTP; phosphoenolpyruvate-forming)" EXACT [EC:4.1.1.32]
synonym: "GTP:oxaloacetate carboxy-lyase (transphosphorylating)" EXACT [EC:4.1.1.32]
synonym: "phosphoenolpyruvate carboxylase (GTP)" EXACT []
synonym: "phosphoenolpyruvic carboxykinase" BROAD [EC:4.1.1.32]
synonym: "phosphoenolpyruvic carboxykinase (GTP)" EXACT [EC:4.1.1.32]
synonym: "phosphoenolpyruvic carboxylase (GTP)" EXACT [EC:4.1.1.32]
synonym: "phosphopyruvate (guanosine triphosphate) carboxykinase activity" EXACT [EC:4.1.1.32]
synonym: "phosphopyruvate carboxylase (GTP)" EXACT [EC:4.1.1.32]
xref: EC:4.1.1.32
xref: MetaCyc:4.1.1.32-RXN
xref: Reactome:REACT_103234 "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol], Mycobacterium tuberculosis"
xref: Reactome:REACT_103706 "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol], Canis familiaris"
xref: Reactome:REACT_104548 "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol], Danio rerio"
xref: Reactome:REACT_107307 "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix], Dictyostelium discoideum"
xref: Reactome:REACT_110231 "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix], Xenopus tropicalis"
xref: Reactome:REACT_115696 "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix], Gallus gallus"
xref: Reactome:REACT_116012 "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol], Gallus gallus"
xref: Reactome:REACT_14793 "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix], Homo sapiens"
xref: Reactome:REACT_259 "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol], Homo sapiens"
xref: Reactome:REACT_31250 "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol], Sus scrofa"
xref: Reactome:REACT_32426 "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix], Drosophila melanogaster"
xref: Reactome:REACT_32939 "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix], Danio rerio"
xref: Reactome:REACT_72784 "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol], Caenorhabditis elegans"
xref: Reactome:REACT_77918 "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix], Bos taurus"
xref: Reactome:REACT_78301 "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix], Canis familiaris"
xref: Reactome:REACT_78361 "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix], Mus musculus"
xref: Reactome:REACT_80744 "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix], Caenorhabditis elegans"
xref: Reactome:REACT_80786 "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix], Rattus norvegicus"
xref: Reactome:REACT_88155 "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol], Gallus gallus"
xref: Reactome:REACT_89417 "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix], Mycobacterium tuberculosis"
xref: Reactome:REACT_91129 "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol], Taeniopygia guttata"
xref: Reactome:REACT_92034 "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix], Sus scrofa"
xref: Reactome:REACT_93986 "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol], Dictyostelium discoideum"
xref: Reactome:REACT_94365 "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol], Drosophila melanogaster"
xref: Reactome:REACT_98157 "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol], Mus musculus"
xref: Reactome:REACT_98346 "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol], Bos taurus"
xref: Reactome:REACT_98537 "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol], Rattus norvegicus"
xref: Reactome:REACT_98633 "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol], Xenopus tropicalis"
xref: RHEA:10391
is_a: GO:0004611 ! phosphoenolpyruvate carboxykinase activity

[Term]
id: GO:0004614
name: phosphoglucomutase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate." [EC:5.4.2.2]
subset: gosubset_prok
synonym: "alpha-D-glucose 1,6-phosphomutase activity" EXACT [EC:5.4.2.2]
synonym: "glucose phosphomutase activity" EXACT [EC:5.4.2.2]
synonym: "phosphoglucose mutase activity" EXACT [EC:5.4.2.2]
xref: EC:5.4.2.2
xref: MetaCyc:PHOSPHOGLUCMUT-RXN
xref: Reactome:REACT_100233 "alpha-D-Glucose 6-phosphate <=> D-Glucose 1-phosphate, Escherichia coli"
xref: Reactome:REACT_102863 "D-Glucose 1-phosphate <=> alpha-D-Glucose 6-phosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_103344 "alpha-D-Glucose 6-phosphate <=> D-Glucose 1-phosphate, Bos taurus"
xref: Reactome:REACT_103582 "D-Glucose 1-phosphate <=> alpha-D-Glucose 6-phosphate, Canis familiaris"
xref: Reactome:REACT_104040 "alpha-D-Glucose 6-phosphate <=> D-Glucose 1-phosphate, Mycobacterium tuberculosis"
xref: Reactome:REACT_105406 "alpha-D-Glucose 6-phosphate <=> D-Glucose 1-phosphate, Gallus gallus"
xref: Reactome:REACT_107017 "alpha-D-Glucose 6-phosphate <=> D-Glucose 1-phosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_107934 "alpha-D-Glucose 6-phosphate <=> D-Glucose 1-phosphate, Canis familiaris"
xref: Reactome:REACT_2164 "alpha-D-Glucose 6-phosphate <=> D-Glucose 1-phosphate, Homo sapiens"
xref: Reactome:REACT_29758 "alpha-D-Glucose 6-phosphate <=> D-Glucose 1-phosphate, Oryza sativa"
xref: Reactome:REACT_29771 "D-Glucose 1-phosphate <=> alpha-D-Glucose 6-phosphate, Escherichia coli"
xref: Reactome:REACT_31205 "D-Glucose 1-phosphate <=> alpha-D-Glucose 6-phosphate, Bos taurus"
xref: Reactome:REACT_32494 "D-Glucose 1-phosphate <=> alpha-D-Glucose 6-phosphate, Taeniopygia guttata"
xref: Reactome:REACT_33200 "D-Glucose 1-phosphate <=> alpha-D-Glucose 6-phosphate, Rattus norvegicus"
xref: Reactome:REACT_52652 "D-Glucose 1-phosphate <=> alpha-D-Glucose 6-phosphate, Gallus gallus"
xref: Reactome:REACT_605 "D-Glucose 1-phosphate <=> alpha-D-Glucose 6-phosphate, Homo sapiens"
xref: Reactome:REACT_78611 "D-Glucose 1-phosphate <=> alpha-D-Glucose 6-phosphate, Dictyostelium discoideum"
xref: Reactome:REACT_80233 "D-Glucose 1-phosphate <=> alpha-D-Glucose 6-phosphate, Mycobacterium tuberculosis"
xref: Reactome:REACT_80806 "D-Glucose 1-phosphate <=> alpha-D-Glucose 6-phosphate, Plasmodium falciparum"
xref: Reactome:REACT_80908 "D-Glucose 1-phosphate <=> alpha-D-Glucose 6-phosphate, Oryza sativa"
xref: Reactome:REACT_81108 "alpha-D-Glucose 6-phosphate <=> D-Glucose 1-phosphate, Dictyostelium discoideum"
xref: Reactome:REACT_82282 "D-Glucose 1-phosphate <=> alpha-D-Glucose 6-phosphate, Danio rerio"
xref: Reactome:REACT_82435 "D-Glucose 1-phosphate <=> alpha-D-Glucose 6-phosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_83033 "D-Glucose 1-phosphate <=> alpha-D-Glucose 6-phosphate, Arabidopsis thaliana"
xref: Reactome:REACT_85304 "alpha-D-Glucose 6-phosphate <=> D-Glucose 1-phosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_85595 "alpha-D-Glucose 6-phosphate <=> D-Glucose 1-phosphate, Mus musculus"
xref: Reactome:REACT_86437 "alpha-D-Glucose 6-phosphate <=> D-Glucose 1-phosphate, Taeniopygia guttata"
xref: Reactome:REACT_87484 "D-Glucose 1-phosphate <=> alpha-D-Glucose 6-phosphate, Sus scrofa"
xref: Reactome:REACT_90041 "alpha-D-Glucose 6-phosphate <=> D-Glucose 1-phosphate, Danio rerio"
xref: Reactome:REACT_91003 "D-Glucose 1-phosphate <=> alpha-D-Glucose 6-phosphate, Xenopus tropicalis"
xref: Reactome:REACT_92754 "alpha-D-Glucose 6-phosphate <=> D-Glucose 1-phosphate, Xenopus tropicalis"
xref: Reactome:REACT_96192 "D-Glucose 1-phosphate <=> alpha-D-Glucose 6-phosphate, Mus musculus"
xref: Reactome:REACT_99526 "alpha-D-Glucose 6-phosphate <=> D-Glucose 1-phosphate, Rattus norvegicus"
xref: Reactome:REACT_99587 "alpha-D-Glucose 6-phosphate <=> D-Glucose 1-phosphate, Plasmodium falciparum"
xref: Reactome:REACT_99858 "alpha-D-Glucose 6-phosphate <=> D-Glucose 1-phosphate, Sus scrofa"
xref: Reactome:REACT_99993 "alpha-D-Glucose 6-phosphate <=> D-Glucose 1-phosphate, Arabidopsis thaliana"
xref: RHEA:23539
is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases

[Term]
id: GO:0004615
name: phosphomannomutase activity
namespace: molecular_function
alt_id: GO:0008971
def: "Catalysis of the reaction: alpha-D-mannose 1-phosphate = D-mannose 6-phosphate." [EC:5.4.2.8, RHEA:11143]
subset: gosubset_prok
synonym: "alpha-D-mannose 1,6-phosphomutase activity" EXACT [EC:5.4.2.8]
synonym: "D-mannose 1,6-phosphomutase activity" EXACT [EC:5.4.2.8]
synonym: "mannose phosphomutase activity" EXACT [EC:5.4.2.8]
synonym: "phosphomannose mutase activity" EXACT [EC:5.4.2.8]
xref: EC:5.4.2.8
xref: KEGG:R01818
xref: MetaCyc:PHOSMANMUT-RXN
xref: Reactome:REACT_22437 "Mannose 6-phosphate isomerizes to Mannose 1-phosphate, Homo sapiens"
xref: RHEA:11143
is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases

[Term]
id: GO:0004616
name: phosphogluconate dehydrogenase (decarboxylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+." [EC:1.1.1.44]
subset: gosubset_prok
synonym: "6-phospho-D-gluconate dehydrogenase activity" EXACT [EC:1.1.1.44]
synonym: "6-phospho-D-gluconate:NADP+ 2-oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.44]
synonym: "6-phosphogluconate dehydrogenase (decarboxylating)" EXACT [EC:1.1.1.44]
synonym: "6-phosphogluconic carboxylase activity" EXACT [EC:1.1.1.44]
synonym: "6-phosphogluconic dehydrogenase activity" BROAD [EC:1.1.1.44]
synonym: "6PGD activity" EXACT [EC:1.1.1.44]
synonym: "phosphogluconic acid dehydrogenase activity" EXACT [EC:1.1.1.44]
xref: EC:1.1.1.44
xref: MetaCyc:6PGLUCONDEHYDROG-RXN
xref: Reactome:REACT_103331 "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+, Staphylococcus aureus N315"
xref: Reactome:REACT_104383 "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+, Mycobacterium tuberculosis"
xref: Reactome:REACT_109406 "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+, Rattus norvegicus"
xref: Reactome:REACT_109572 "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+, Schizosaccharomyces pombe"
xref: Reactome:REACT_109991 "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+, Saccharomyces cerevisiae"
xref: Reactome:REACT_31932 "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+, Xenopus tropicalis"
xref: Reactome:REACT_32300 "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+, Dictyostelium discoideum"
xref: Reactome:REACT_611 "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+, Homo sapiens"
xref: Reactome:REACT_82331 "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+, Drosophila melanogaster"
xref: Reactome:REACT_82909 "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+, Bos taurus"
xref: Reactome:REACT_88069 "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+, Taeniopygia guttata"
xref: Reactome:REACT_89491 "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+, Danio rerio"
xref: Reactome:REACT_91295 "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+, Sus scrofa"
xref: Reactome:REACT_94646 "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+, Mus musculus"
xref: Reactome:REACT_95162 "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+, Canis familiaris"
xref: Reactome:REACT_95990 "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+, Escherichia coli"
xref: Reactome:REACT_96954 "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+, Plasmodium falciparum"
xref: Reactome:REACT_97345 "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+, Gallus gallus"
xref: Reactome:REACT_98017 "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+, Caenorhabditis elegans"
xref: RHEA:10119
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004617
name: phosphoglycerate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+." [EC:1.1.1.95]
subset: gosubset_prok
synonym: "3-phospho-D-glycerate:NAD+ 2-oxidoreductase activity" EXACT [EC:1.1.1.95]
synonym: "3-phosphoglycerate dehydrogenase activity" EXACT [EC:1.1.1.95]
synonym: "3-phosphoglycerate:NAD+ 2-oxidoreductase activity" EXACT [EC:1.1.1.95]
synonym: "3-phosphoglyceric acid dehydrogenase activity" EXACT [EC:1.1.1.95]
synonym: "3PHP reductase activity" EXACT [EC:1.1.1.95]
synonym: "alpha-KG reductase activity" EXACT [EC:1.1.1.95]
synonym: "alpha-phosphoglycerate dehydrogenase activity" EXACT [EC:1.1.1.95]
synonym: "alphaKG reductase activity" EXACT [EC:1.1.1.95]
synonym: "D- and L-HGA" RELATED [EC:1.1.1.95]
synonym: "D-3-phosphoglycerate dehydrogenase activity" EXACT [EC:1.1.1.95]
synonym: "D-3-phosphoglycerate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.95]
synonym: "glycerate 3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.95]
synonym: "glycerate-1,3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.95]
synonym: "PGDH activity" EXACT [EC:1.1.1.95]
synonym: "phosphoglycerate oxidoreductase activity" EXACT [EC:1.1.1.95]
synonym: "phosphoglyceric acid dehydrogenase activity" EXACT [EC:1.1.1.95]
synonym: "SerA" RELATED [EC:1.1.1.95]
synonym: "SerA 3PG dehydrogenase activity" EXACT [EC:1.1.1.95]
xref: EC:1.1.1.95
xref: MetaCyc:PGLYCDEHYDROG-RXN
xref: Reactome:REACT_116077 "3-phosphoglycerate is dehydrogenated, Homo sapiens"
xref: RHEA:12644
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004618
name: phosphoglycerate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-phospho-D-glycerate + ATP = 3-phospho-D-glyceroyl phosphate + ADP + H(+)." [EC:2.7.2.3, RHEA:14804]
subset: gosubset_prok
synonym: "3-PGK" RELATED [EC:2.7.2.3]
synonym: "3-phosphoglycerate kinase activity" EXACT [EC:2.7.2.3]
synonym: "3-phosphoglycerate phosphokinase activity" EXACT [EC:2.7.2.3]
synonym: "3-phosphoglyceric acid kinase activity" EXACT [EC:2.7.2.3]
synonym: "3-phosphoglyceric acid phosphokinase activity" EXACT [EC:2.7.2.3]
synonym: "3-phosphoglyceric kinase activity" EXACT [EC:2.7.2.3]
synonym: "ATP-3-phospho-D-glycerate-1-phosphotransferase activity" EXACT [EC:2.7.2.3]
synonym: "ATP:3-phospho-D-glycerate 1-phosphotransferase activity" EXACT [EC:2.7.2.3]
synonym: "ATP:D-3-phosphoglycerate 1-phosphotransferase activity" EXACT [EC:2.7.2.3]
synonym: "glycerate 3-phosphate kinase activity" EXACT [EC:2.7.2.3]
synonym: "glycerophosphate kinase activity" EXACT [EC:2.7.2.3]
synonym: "PGK" RELATED [EC:2.7.2.3]
synonym: "phosphoglyceric acid kinase activity" EXACT [EC:2.7.2.3]
synonym: "phosphoglyceric kinase activity" EXACT [EC:2.7.2.3]
synonym: "phosphoglycerokinase activity" EXACT [EC:2.7.2.3]
xref: EC:2.7.2.3
xref: KEGG:R01512
xref: MetaCyc:PHOSGLYPHOS-RXN
xref: Reactome:REACT_113751 "ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate, Dictyostelium discoideum"
xref: Reactome:REACT_114935 "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ADP, Dictyostelium discoideum"
xref: Reactome:REACT_115775 "3-phosphoglycerate + ATP <=> 1,3-bisphosphoglycerate + ADP, Gallus gallus"
xref: Reactome:REACT_115924 "1,3-bisphosphoglycerate + ADP <=> 3-phosphoglycerate + ATP, Gallus gallus"
xref: Reactome:REACT_1186 "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ADP, Homo sapiens"
xref: Reactome:REACT_29938 "ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate, Plasmodium falciparum"
xref: Reactome:REACT_30677 "ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate, Saccharomyces cerevisiae"
xref: Reactome:REACT_31518 "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ADP, Xenopus tropicalis"
xref: Reactome:REACT_31758 "ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate, Rattus norvegicus"
xref: Reactome:REACT_432 "ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate, Homo sapiens"
xref: Reactome:REACT_77636 "ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate, Bos taurus"
xref: Reactome:REACT_80075 "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ADP, Rattus norvegicus"
xref: Reactome:REACT_80659 "ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate, Gallus gallus"
xref: Reactome:REACT_81461 "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ADP, Mus musculus"
xref: Reactome:REACT_82233 "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ADP, Staphylococcus aureus N315"
xref: Reactome:REACT_82529 "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ADP, Gallus gallus"
xref: Reactome:REACT_84357 "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ADP, Danio rerio"
xref: Reactome:REACT_87378 "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ADP, Sus scrofa"
xref: Reactome:REACT_88105 "ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate, Drosophila melanogaster"
xref: Reactome:REACT_88146 "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ADP, Drosophila melanogaster"
xref: Reactome:REACT_88245 "ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate, Staphylococcus aureus N315"
xref: Reactome:REACT_89364 "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ADP, Taeniopygia guttata"
xref: Reactome:REACT_90044 "ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate, Mus musculus"
xref: Reactome:REACT_90420 "ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate, Danio rerio"
xref: Reactome:REACT_91090 "ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate, Xenopus tropicalis"
xref: Reactome:REACT_92250 "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ADP, Schizosaccharomyces pombe"
xref: Reactome:REACT_94497 "ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate, Schizosaccharomyces pombe"
xref: Reactome:REACT_94863 "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ADP, Bos taurus"
xref: Reactome:REACT_94954 "ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate, Taeniopygia guttata"
xref: Reactome:REACT_96479 "ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate, Sus scrofa"
xref: Reactome:REACT_96646 "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ADP, Canis familiaris"
xref: Reactome:REACT_97291 "ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate, Canis familiaris"
xref: Reactome:REACT_97790 "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ADP, Plasmodium falciparum"
xref: Reactome:REACT_99968 "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ADP, Saccharomyces cerevisiae"
xref: RHEA:14804
is_a: GO:0016301 ! kinase activity
is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor

[Term]
id: GO:0004619
name: phosphoglycerate mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate." [EC:5.4.2.1]
subset: gosubset_prok
synonym: "bisphosphoglyceromutase" RELATED [EC:5.4.2.1]
synonym: "D-phosphoglycerate 2,3-phosphomutase activity" EXACT [EC:5.4.2.1]
synonym: "diphosphoglycomutase" RELATED [EC:5.4.2.1]
synonym: "GriP mutase" NARROW [EC:5.4.2.1]
synonym: "monophosphoglycerate mutase activity" EXACT [EC:5.4.2.1]
synonym: "monophosphoglyceromutase activity" EXACT [EC:5.4.2.1]
synonym: "MPGM" RELATED [EC:5.4.2.1]
synonym: "PGA mutase activity" EXACT [EC:5.4.2.1]
synonym: "PGAM activity" EXACT [EC:5.4.2.1]
synonym: "PGM" EXACT []
synonym: "phosphoglycerate phosphomutase activity" EXACT [EC:5.4.2.1]
synonym: "phosphoglyceromutase activity" EXACT [EC:5.4.2.1]
xref: EC:5.4.2.1
xref: MetaCyc:3PGAREARR-RXN
xref: Reactome:REACT_103744 "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate, Oryza sativa"
xref: Reactome:REACT_104989 "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate, Staphylococcus aureus N315"
xref: Reactome:REACT_105247 "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate, Danio rerio"
xref: Reactome:REACT_106697 "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate, Sus scrofa"
xref: Reactome:REACT_111991 "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate, Plasmodium falciparum"
xref: Reactome:REACT_112712 "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate, Plasmodium falciparum"
xref: Reactome:REACT_112969 "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate, Escherichia coli"
xref: Reactome:REACT_114968 "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate, Dictyostelium discoideum"
xref: Reactome:REACT_115206 "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate, Dictyostelium discoideum"
xref: Reactome:REACT_115355 "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate, Escherichia coli"
xref: Reactome:REACT_116032 "3-phosphoglycerate <=> 2-phosphoglycerate, Gallus gallus"
xref: Reactome:REACT_116142 "2-phosphoglycerate <=> 3-phosphoglycerate, Gallus gallus"
xref: Reactome:REACT_29464 "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate, Bos taurus"
xref: Reactome:REACT_29474 "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate, Drosophila melanogaster"
xref: Reactome:REACT_31484 "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate, Rattus norvegicus"
xref: Reactome:REACT_576 "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate, Homo sapiens"
xref: Reactome:REACT_766 "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate, Homo sapiens"
xref: Reactome:REACT_80395 "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate, Bos taurus"
xref: Reactome:REACT_81431 "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate, Arabidopsis thaliana"
xref: Reactome:REACT_81432 "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate, Rattus norvegicus"
xref: Reactome:REACT_82081 "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate, Mus musculus"
xref: Reactome:REACT_82507 "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate, Canis familiaris"
xref: Reactome:REACT_88463 "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate, Oryza sativa"
xref: Reactome:REACT_89277 "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate, Staphylococcus aureus N315"
xref: Reactome:REACT_91956 "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate, Drosophila melanogaster"
xref: Reactome:REACT_92327 "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate, Xenopus tropicalis"
xref: Reactome:REACT_92964 "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate, Sus scrofa"
xref: Reactome:REACT_94038 "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate, Danio rerio"
xref: Reactome:REACT_94108 "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate, Mus musculus"
xref: Reactome:REACT_94205 "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate, Xenopus tropicalis"
xref: Reactome:REACT_95665 "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate, Schizosaccharomyces pombe"
xref: Reactome:REACT_96558 "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate, Arabidopsis thaliana"
xref: Reactome:REACT_96674 "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate, Canis familiaris"
xref: Reactome:REACT_96785 "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate, Schizosaccharomyces pombe"
xref: RHEA:15904
is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases

[Term]
id: GO:0004620
name: phospholipase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a glycerophospholipid." [ISBN:0198506732]
subset: goslim_chembl
subset: gosubset_prok
xref: EC:3.1.1.-
is_a: GO:0016298 ! lipase activity

[Term]
id: GO:0004621
name: glycosylphosphatidylinositol phospholipase D activity
namespace: molecular_function
def: "Catalysis of the reaction: glycoprotein phosphatidylinositol + H2O = phosphatidate + glycoprotein inositol." [EC:3.1.4.50]
synonym: "glycoprotein phospholipase D activity" EXACT []
synonym: "glycoprotein-phosphatidylinositol phosphatidohydrolase activity" EXACT [EC:3.1.4.50]
synonym: "GPI-PLD activity" EXACT [EC:3.1.4.50]
synonym: "phosphatidylinositol phospholipase D activity" EXACT [EC:3.1.4.50]
synonym: "phosphatidylinositol-glycan-specific phospholipase D activity" EXACT [EC:3.1.4.50]
synonym: "phosphatidylinositol-specific phospholipase D activity" EXACT [EC:3.1.4.50]
xref: EC:3.1.4.50
xref: MetaCyc:GLYCOPROTEIN-PHOSPHOLIPASE-D-RXN
xref: RHEA:10835
is_a: GO:0004630 ! phospholipase D activity

[Term]
id: GO:0004622
name: lysophospholipase activity
namespace: molecular_function
alt_id: GO:0045126
def: "Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate." [EC:3.1.1.5]
subset: goslim_chembl
subset: gosubset_prok
synonym: "2-lysophosphatidylcholine acylhydrolase activity" EXACT [EC:3.1.1.5]
synonym: "lecithinase B activity" EXACT [EC:3.1.1.5]
synonym: "lecitholipase activity" EXACT [EC:3.1.1.5]
synonym: "lysolecithinase activity" EXACT [EC:3.1.1.5]
synonym: "lysophopholipase L2" RELATED [EC:3.1.1.5]
synonym: "lysophosphatidase activity" EXACT [EC:3.1.1.5]
synonym: "lysophosphatidylcholine hydrolase activity" EXACT [EC:3.1.1.5]
synonym: "lysophospholipase A1" RELATED [EC:3.1.1.5]
synonym: "phosphatidase B" RELATED [EC:3.1.1.5]
synonym: "phospholipase B activity" EXACT [EC:3.1.1.5]
xref: EC:3.1.1.5
xref: MetaCyc:LYSOPHOSPHOLIPASE-RXN
xref: RHEA:15180
is_a: GO:0004620 ! phospholipase activity
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0004623
name: phospholipase A2 activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.4]
subset: goslim_chembl
subset: gosubset_prok
synonym: "cytosolic phospholipase A2 activity" NARROW []
synonym: "lecithinase A activity" EXACT [EC:3.1.1.4]
synonym: "phosphatidase activity" RELATED [EC:3.1.1.4]
synonym: "phosphatidolipase activity" EXACT [EC:3.1.1.4]
synonym: "phosphatidylcholine 2-acylhydrolase activity" EXACT [EC:3.1.1.4]
synonym: "phospholipase A" RELATED [EC:3.1.1.4]
synonym: "secreted phospholipase A2 activity" NARROW []
xref: EC:3.1.1.4
xref: MetaCyc:PHOSPHOLIPASE-A2-RXN
xref: RHEA:15804
is_a: GO:0004620 ! phospholipase activity
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0004624
name: obsolete secreted phospholipase A2 activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.4]
comment: This term was made obsolete because it represents component and function information.
synonym: "secreted phospholipase A2 activity" EXACT []
is_obsolete: true
consider: GO:0004623
consider: GO:0005576

[Term]
id: GO:0004625
name: obsolete calcium-dependent secreted phospholipase A2 activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.4]
comment: This term was made obsolete because it represents component and function information.
synonym: "calcium-dependent secreted phospholipase A2 activity" EXACT []
is_obsolete: true
consider: GO:0005576
consider: GO:0047498

[Term]
id: GO:0004626
name: obsolete cytosolic phospholipase A2 activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.4]
comment: This term was made obsolete because it represents component and function information.
synonym: "cytosolic phospholipase A2 activity" EXACT []
is_obsolete: true
consider: GO:0004623
consider: GO:0005829

[Term]
id: GO:0004627
name: obsolete calcium-dependent cytosolic phospholipase A2 activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.4]
comment: This term was made obsolete because it represents component and function information.
synonym: "calcium-dependent cytosolic phospholipase A2 activity" EXACT []
is_obsolete: true
consider: GO:0005829
consider: GO:0047498

[Term]
id: GO:0004628
name: obsolete calcium-independent cytosolic phospholipase A2 activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.4]
comment: This term was made obsolete because it represents component and function information.
synonym: "calcium-independent cytosolic phospholipase A2 activity" EXACT []
is_obsolete: true
consider: GO:0005829
consider: GO:0047499

[Term]
id: GO:0004629
name: phospholipase C activity
namespace: molecular_function
alt_id: GO:0042298
def: "Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate." [EC:3.1.4.3, EC:3.1.4.4, GOC:mah]
subset: gosubset_prok
synonym: "lecithinase C activity" RELATED [EC:3.1.4.3]
synonym: "lipophosphodiesterase C" RELATED [EC:3.1.4.3]
synonym: "phosphatidase C" RELATED [EC:3.1.4.3]
xref: MetaCyc:PHOSPHOLIPASE-C-RXN
xref: Reactome:REACT_100688 "PLC gamma 2-mediated PIP2 hydrolysis, Gallus gallus"
xref: Reactome:REACT_102616 "PLC gamma 2-mediated PIP2 hydrolysis, Rattus norvegicus"
xref: Reactome:REACT_102640 "PLC beta-mediated PIP2 hydrolysis, Danio rerio"
xref: Reactome:REACT_103548 "Hydrolysis of 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate by Activated Phospholipase C Beta-1, Drosophila melanogaster"
xref: Reactome:REACT_105325 "PLC beta-mediated PIP2 hydrolysis, Gallus gallus"
xref: Reactome:REACT_105673 "PLC beta-mediated PIP2 hydrolysis, Mus musculus"
xref: Reactome:REACT_107508 "PLC beta-mediated PIP2 hydrolysis, Rattus norvegicus"
xref: Reactome:REACT_109008 "PLC beta-mediated PIP2 hydrolysis, Sus scrofa"
xref: Reactome:REACT_109501 "Hydrolysis of 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate by Activated Phospholipase C Beta-1, Gallus gallus"
xref: Reactome:REACT_109627 "Hydrolysis of 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate by Activated Phospholipase C Beta-1, Bos taurus"
xref: Reactome:REACT_109971 "PLC gamma 2-mediated PIP2 hydrolysis, Danio rerio"
xref: Reactome:REACT_110061 "PLC gamma 2-mediated PIP2 hydrolysis, Taeniopygia guttata"
xref: Reactome:REACT_110223 "Hydrolysis of 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate by Activated Phospholipase C Beta-1, Rattus norvegicus"
xref: Reactome:REACT_112092 "PLC gamma 2-mediated PIP2 hydrolysis, Caenorhabditis elegans"
xref: Reactome:REACT_112217 "PLC beta-mediated PIP2 hydrolysis, Schizosaccharomyces pombe"
xref: Reactome:REACT_112221 "Hydrolysis of 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate by Activated Phospholipase C Beta-1, Saccharomyces cerevisiae"
xref: Reactome:REACT_112517 "PLC beta-mediated PIP2 hydrolysis, Saccharomyces cerevisiae"
xref: Reactome:REACT_112637 "PLC gamma 2-mediated PIP2 hydrolysis, Drosophila melanogaster"
xref: Reactome:REACT_112759 "PLC beta-mediated PIP2 hydrolysis, Dictyostelium discoideum"
xref: Reactome:REACT_112950 "PLC gamma 2-mediated PIP2 hydrolysis, Arabidopsis thaliana"
xref: Reactome:REACT_113114 "Hydrolysis of 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate by Activated Phospholipase C Beta-1, Dictyostelium discoideum"
xref: Reactome:REACT_113364 "PLC gamma 2-mediated PIP2 hydrolysis, Dictyostelium discoideum"
xref: Reactome:REACT_113464 "PLC gamma 2-mediated PIP2 hydrolysis, Plasmodium falciparum"
xref: Reactome:REACT_113587 "PLC gamma 2-mediated PIP2 hydrolysis, Saccharomyces cerevisiae"
xref: Reactome:REACT_114558 "Hydrolysis of 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate by Activated Phospholipase C Beta-1, Danio rerio"
xref: Reactome:REACT_114743 "PLC gamma 2-mediated PIP2 hydrolysis, Oryza sativa"
xref: Reactome:REACT_115019 "Hydrolysis of 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate by Activated Phospholipase C Beta-1, Schizosaccharomyces pombe"
xref: Reactome:REACT_115219 "PLC gamma 2-mediated PIP2 hydrolysis, Schizosaccharomyces pombe"
xref: Reactome:REACT_18383 "Hydrolysis of 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate by Activated Phospholipase C Beta-1, Homo sapiens"
xref: Reactome:REACT_19319 "PLC beta-mediated PIP2 hydrolysis, Homo sapiens"
xref: Reactome:REACT_265 "PLC gamma 2-mediated PIP2 hydrolysis, Homo sapiens"
xref: Reactome:REACT_28636 "PLC beta-mediated PIP2 hydrolysis, Drosophila melanogaster"
xref: Reactome:REACT_30576 "Hydrolysis of 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate by Activated Phospholipase C Beta-1, Mus musculus"
xref: Reactome:REACT_34377 "PLC beta-mediated PIP2 hydrolysis, Xenopus tropicalis"
xref: Reactome:REACT_77887 "PLC beta-mediated PIP2 hydrolysis, Xenopus tropicalis"
xref: Reactome:REACT_78670 "PLC beta-mediated PIP2 hydrolysis, Bos taurus"
xref: Reactome:REACT_80473 "PLC beta-mediated PIP2 hydrolysis, Caenorhabditis elegans"
xref: Reactome:REACT_80604 "PLC beta-mediated PIP2 hydrolysis, Gallus gallus"
xref: Reactome:REACT_83349 "PLC beta-mediated PIP2 hydrolysis, Canis familiaris"
xref: Reactome:REACT_83947 "Hydrolysis of 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate by Activated Phospholipase C Beta-1, Canis familiaris"
xref: Reactome:REACT_87114 "PLC gamma 2-mediated PIP2 hydrolysis, Mus musculus"
xref: Reactome:REACT_89248 "PLC beta-mediated PIP2 hydrolysis, Taeniopygia guttata"
xref: Reactome:REACT_90096 "PLC gamma 2-mediated PIP2 hydrolysis, Canis familiaris"
xref: Reactome:REACT_92753 "PLC beta-mediated PIP2 hydrolysis, Canis familiaris"
xref: Reactome:REACT_93255 "PLC beta-mediated PIP2 hydrolysis, Taeniopygia guttata"
xref: Reactome:REACT_93698 "Hydrolysis of 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate by Activated Phospholipase C Beta-1, Taeniopygia guttata"
xref: Reactome:REACT_94137 "PLC beta-mediated PIP2 hydrolysis, Mus musculus"
xref: Reactome:REACT_94162 "PLC gamma 2-mediated PIP2 hydrolysis, Xenopus tropicalis"
xref: Reactome:REACT_95661 "Hydrolysis of 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate by Activated Phospholipase C Beta-1, Xenopus tropicalis"
xref: Reactome:REACT_95943 "PLC beta-mediated PIP2 hydrolysis, Bos taurus"
xref: Reactome:REACT_960 "PLC beta-mediated PIP2 hydrolysis, Homo sapiens"
xref: Reactome:REACT_96475 "PLC gamma 2-mediated PIP2 hydrolysis, Bos taurus"
xref: Reactome:REACT_98409 "PLC beta-mediated PIP2 hydrolysis, Danio rerio"
xref: Reactome:REACT_98758 "PLC gamma 2-mediated PIP2 hydrolysis, Sus scrofa"
is_a: GO:0004620 ! phospholipase activity
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0004630
name: phospholipase D activity
namespace: molecular_function
def: "Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate." [EC:3.1.4.4]
subset: goslim_chembl
subset: gosubset_prok
synonym: "choline phosphatase activity" EXACT [EC:3.1.4.4]
synonym: "lecithinase D activity" EXACT [EC:3.1.4.4]
synonym: "lipophosphodiesterase II activity" EXACT [EC:3.1.4.4]
synonym: "phosphatidylcholine phosphatidohydrolase activity" EXACT [EC:3.1.4.4]
xref: EC:3.1.4.4
xref: MetaCyc:PHOSCHOL-RXN
is_a: GO:0004620 ! phospholipase activity
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0004631
name: phosphomevalonate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP + H(+)." [EC:2.7.4.2, RHEA:16344]
subset: gosubset_prok
synonym: "5-phosphomevalonate kinase activity" EXACT [EC:2.7.4.2]
synonym: "ATP:(R)-5-phosphomevalonate phosphotransferase activity" EXACT [EC:2.7.4.2]
synonym: "ATP:5-phosphomevalonate phosphotransferase activity" EXACT [EC:2.7.4.2]
synonym: "mevalonate phosphate kinase activity" EXACT [EC:2.7.4.2]
synonym: "mevalonate-5-phosphate kinase activity" EXACT [EC:2.7.4.2]
synonym: "mevalonic acid phosphate kinase activity" EXACT [EC:2.7.4.2]
xref: EC:2.7.4.2
xref: KEGG:R03245
xref: MetaCyc:PHOSPHOMEVALONATE-KINASE-RXN
xref: Reactome:REACT_101959 "Mevalonate-5-phosphate is further phosphorylated., Caenorhabditis elegans"
xref: Reactome:REACT_102301 "Mevalonate-5-phosphate is further phosphorylated., Sus scrofa"
xref: Reactome:REACT_104617 "Mevalonate-5-phosphate is further phosphorylated., Canis familiaris"
xref: Reactome:REACT_32030 "Mevalonate-5-phosphate is further phosphorylated., Drosophila melanogaster"
xref: Reactome:REACT_33204 "Mevalonate-5-phosphate is further phosphorylated., Mus musculus"
xref: Reactome:REACT_79309 "Mevalonate-5-phosphate is further phosphorylated., Bos taurus"
xref: Reactome:REACT_89198 "Mevalonate-5-phosphate is further phosphorylated., Danio rerio"
xref: Reactome:REACT_9496 "Mevalonate-5-phosphate is further phosphorylated., Homo sapiens"
xref: Reactome:REACT_98039 "Mevalonate-5-phosphate is further phosphorylated., Rattus norvegicus"
xref: RHEA:16344
is_a: GO:0016301 ! kinase activity
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor

[Term]
id: GO:0004632
name: phosphopantothenate--cysteine ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + (R)-4'-phosphopantothenoyl-L-cysteine. Cysteine can be replaced by some of its derivatives." [EC:6.3.2.5]
subset: gosubset_prok
synonym: "(R)-4'-phosphopantothenate:L-cysteine ligase activity" EXACT [EC:6.3.2.5]
synonym: "phosphopantothenate-cysteine ligase activity" EXACT []
synonym: "phosphopantothenoylcysteine synthetase activity" EXACT []
xref: EC:6.3.2.5
xref: MetaCyc:P-PANTOCYSLIG-RXN
xref: Reactome:REACT_106424 "Condensation of phosphopantothenate with cysteine, Drosophila melanogaster"
xref: Reactome:REACT_107281 "Condensation of phosphopantothenate with cysteine, Rattus norvegicus"
xref: Reactome:REACT_108690 "Condensation of phosphopantothenate with cysteine, Dictyostelium discoideum"
xref: Reactome:REACT_108917 "Condensation of phosphopantothenate with cysteine, Danio rerio"
xref: Reactome:REACT_11112 "Condensation of phosphopantothenate with cysteine, Homo sapiens"
xref: Reactome:REACT_112895 "Condensation of phosphopantothenate with cysteine, Oryza sativa"
xref: Reactome:REACT_113780 "Condensation of phosphopantothenate with cysteine, Arabidopsis thaliana"
xref: Reactome:REACT_28344 "Condensation of phosphopantothenate with cysteine, Gallus gallus"
xref: Reactome:REACT_31524 "Condensation of phosphopantothenate with cysteine, Schizosaccharomyces pombe"
xref: Reactome:REACT_31917 "Condensation of phosphopantothenate with cysteine, Sus scrofa"
xref: Reactome:REACT_33048 "Condensation of phosphopantothenate with cysteine, Bos taurus"
xref: Reactome:REACT_86512 "Condensation of phosphopantothenate with cysteine, Xenopus tropicalis"
xref: Reactome:REACT_89980 "Condensation of phosphopantothenate with cysteine, Caenorhabditis elegans"
xref: Reactome:REACT_90205 "Condensation of phosphopantothenate with cysteine, Canis familiaris"
xref: Reactome:REACT_92288 "Condensation of phosphopantothenate with cysteine, Plasmodium falciparum"
xref: Reactome:REACT_94542 "Condensation of phosphopantothenate with cysteine, Mus musculus"
xref: Reactome:REACT_96632 "Condensation of phosphopantothenate with cysteine, Taeniopygia guttata"
xref: Reactome:REACT_97589 "Condensation of phosphopantothenate with cysteine, Saccharomyces cerevisiae"
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0004633
name: phosphopantothenoylcysteine decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate + H(+) = CO(2) + pantetheine 4'-phosphate." [EC:4.1.1.36, RHEA:16796]
subset: gosubset_prok
synonym: "4-phosphopantothenoyl-L-cysteine decarboxylase activity" EXACT [EC:4.1.1.36]
synonym: "4-phosphopantotheoylcysteine decarboxylase activity" EXACT [EC:4.1.1.36]
synonym: "N-((R)-4'-phosphopantothenoyl)-L-cysteine carboxy-lyase activity" EXACT [EC:4.1.1.36]
synonym: "N-[(R)-4'-phosphopantothenoyl]-L-cysteine carboxy-lyase (pantotheine-4'-phosphate-forming)" EXACT [EC:4.1.1.36]
synonym: "N-[(R)-4'-phosphopantothenoyl]-L-cysteine carboxy-lyase activity" EXACT [EC:4.1.1.36]
synonym: "PPC-decarboxylase activity" EXACT [EC:4.1.1.36]
xref: EC:4.1.1.36
xref: KEGG:R03269
xref: MetaCyc:P-PANTOCYSDECARB-RXN
xref: Reactome:REACT_104962 "Phosphopantothenoylcysteine is decarboxylated, Staphylococcus aureus N315"
xref: Reactome:REACT_106657 "Phosphopantothenoylcysteine is decarboxylated, Xenopus tropicalis"
xref: Reactome:REACT_110311 "Phosphopantothenoylcysteine is decarboxylated, Plasmodium falciparum"
xref: Reactome:REACT_11231 "Phosphopantothenoylcysteine is decarboxylated, Homo sapiens"
xref: Reactome:REACT_28231 "Phosphopantothenoylcysteine is decarboxylated, Saccharomyces cerevisiae"
xref: Reactome:REACT_32112 "Phosphopantothenoylcysteine is decarboxylated, Mycobacterium tuberculosis"
xref: Reactome:REACT_33942 "Phosphopantothenoylcysteine is decarboxylated, Escherichia coli"
xref: Reactome:REACT_77525 "Phosphopantothenoylcysteine is decarboxylated, Caenorhabditis elegans"
xref: Reactome:REACT_82961 "Phosphopantothenoylcysteine is decarboxylated, Drosophila melanogaster"
xref: Reactome:REACT_82986 "Phosphopantothenoylcysteine is decarboxylated, Gallus gallus"
xref: Reactome:REACT_83243 "Phosphopantothenoylcysteine is decarboxylated, Arabidopsis thaliana"
xref: Reactome:REACT_84202 "Phosphopantothenoylcysteine is decarboxylated, Sus scrofa"
xref: Reactome:REACT_85091 "Phosphopantothenoylcysteine is decarboxylated, Dictyostelium discoideum"
xref: Reactome:REACT_86292 "Phosphopantothenoylcysteine is decarboxylated, Bos taurus"
xref: Reactome:REACT_87981 "Phosphopantothenoylcysteine is decarboxylated, Taeniopygia guttata"
xref: Reactome:REACT_90169 "Phosphopantothenoylcysteine is decarboxylated, Danio rerio"
xref: Reactome:REACT_90636 "Phosphopantothenoylcysteine is decarboxylated, Mus musculus"
xref: Reactome:REACT_94568 "Phosphopantothenoylcysteine is decarboxylated, Oryza sativa"
xref: Reactome:REACT_97295 "Phosphopantothenoylcysteine is decarboxylated, Rattus norvegicus"
xref: Reactome:REACT_99978 "Phosphopantothenoylcysteine is decarboxylated, Canis familiaris"
xref: RHEA:16796
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004634
name: phosphopyruvate hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O." [EC:4.2.1.11, ISBN:0198506732]
subset: gosubset_prok
synonym: "14-3-2-protein" RELATED [EC:4.2.1.11]
synonym: "2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)" EXACT [EC:4.2.1.11]
synonym: "2-phospho-D-glycerate hydro-lyase activity" EXACT [EC:4.2.1.11]
synonym: "2-phospho-D-glycerate-hydrolase activity" EXACT []
synonym: "2-phosphoglycerate dehydratase activity" EXACT [EC:4.2.1.11]
synonym: "2-phosphoglycerate enolase activity" EXACT [EC:4.2.1.11]
synonym: "2-phosphoglyceric dehydratase activity" EXACT [EC:4.2.1.11]
synonym: "enolase activity" EXACT [EC:4.2.1.11]
synonym: "gamma-enolase activity" EXACT [EC:4.2.1.11]
synonym: "nervous-system specific enolase" NARROW [EC:4.2.1.11]
synonym: "phosphoenolpyruvate hydratase activity" EXACT [EC:4.2.1.11]
xref: EC:4.2.1.11
xref: MetaCyc:2PGADEHYDRAT-RXN
xref: Reactome:REACT_101442 "Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate, Rattus norvegicus"
xref: Reactome:REACT_101853 "Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate, Canis familiaris"
xref: Reactome:REACT_102602 "Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate, Xenopus tropicalis"
xref: Reactome:REACT_104653 "Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate, Bos taurus"
xref: Reactome:REACT_106080 "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O, Caenorhabditis elegans"
xref: Reactome:REACT_107686 "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O, Rattus norvegicus"
xref: Reactome:REACT_109642 "Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate, Gallus gallus"
xref: Reactome:REACT_112068 "Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate, Mycobacterium tuberculosis"
xref: Reactome:REACT_112478 "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O, Saccharomyces cerevisiae"
xref: Reactome:REACT_112581 "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O, Schizosaccharomyces pombe"
xref: Reactome:REACT_112691 "Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate, Saccharomyces cerevisiae"
xref: Reactome:REACT_112925 "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O, Mycobacterium tuberculosis"
xref: Reactome:REACT_112986 "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O, Escherichia coli"
xref: Reactome:REACT_113494 "Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate, Dictyostelium discoideum"
xref: Reactome:REACT_113501 "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O, Oryza sativa"
xref: Reactome:REACT_113666 "Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate, Escherichia coli"
xref: Reactome:REACT_113784 "Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate, Arabidopsis thaliana"
xref: Reactome:REACT_113920 "Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate, Oryza sativa"
xref: Reactome:REACT_114214 "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O, Plasmodium falciparum"
xref: Reactome:REACT_114276 "Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate, Schizosaccharomyces pombe"
xref: Reactome:REACT_114578 "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O, Staphylococcus aureus N315"
xref: Reactome:REACT_115184 "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O, Dictyostelium discoideum"
xref: Reactome:REACT_115250 "Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate, Staphylococcus aureus N315"
xref: Reactome:REACT_115259 "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O, Arabidopsis thaliana"
xref: Reactome:REACT_115437 "Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate, Plasmodium falciparum"
xref: Reactome:REACT_115806 "phosphoenolpyruvate + H2O <=> 2-phosphoglycerate, Gallus gallus"
xref: Reactome:REACT_116100 "2-phosphoglycerate <=> phosphoenolpyruvate + H2O, Gallus gallus"
xref: Reactome:REACT_1400 "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O, Homo sapiens"
xref: Reactome:REACT_2018 "Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate, Homo sapiens"
xref: Reactome:REACT_28235 "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O, Taeniopygia guttata"
xref: Reactome:REACT_28558 "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O, Sus scrofa"
xref: Reactome:REACT_31822 "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O, Bos taurus"
xref: Reactome:REACT_33506 "Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate, Sus scrofa"
xref: Reactome:REACT_77297 "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O, Danio rerio"
xref: Reactome:REACT_78560 "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O, Canis familiaris"
xref: Reactome:REACT_80232 "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O, Mus musculus"
xref: Reactome:REACT_81522 "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O, Xenopus tropicalis"
xref: Reactome:REACT_87340 "Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate, Danio rerio"
xref: Reactome:REACT_91534 "Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate, Taeniopygia guttata"
xref: Reactome:REACT_93012 "Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate, Drosophila melanogaster"
xref: Reactome:REACT_95724 "Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate, Caenorhabditis elegans"
xref: Reactome:REACT_96316 "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O, Drosophila melanogaster"
xref: Reactome:REACT_97592 "Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate, Mus musculus"
xref: Reactome:REACT_98214 "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O, Gallus gallus"
xref: RHEA:10167
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0004635
name: phosphoribosyl-AMP cyclohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-(5-phosphonatoribosyl)-5'-AMP + H(2)O = 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide." [EC:3.5.4.19, RHEA:20052]
subset: gosubset_prok
synonym: "1-(5-phospho-D-ribosyl)-AMP 1,6-hydrolase activity" EXACT [EC:3.5.4.19]
synonym: "phosphoribosyladenosine monophosphate cyclohydrolase activity" EXACT [EC:3.5.4.19]
synonym: "PRAMP-cyclohydrolase activity" EXACT [EC:3.5.4.19]
xref: EC:3.5.4.19
xref: KEGG:R04037
xref: MetaCyc:HISTCYCLOHYD-RXN
xref: RHEA:20052
is_a: GO:0019238 ! cyclohydrolase activity

[Term]
id: GO:0004636
name: phosphoribosyl-ATP diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + H(2)O = 1-(5-phosphonatoribosyl)-5'-AMP + diphosphate + H(+)." [EC:3.6.1.31, RHEA:22831]
subset: gosubset_prok
synonym: "1-(5-phosphoribosyl)-ATP diphosphohydrolase activity" EXACT [EC:3.6.1.31]
synonym: "phosphoribosyl-ATP pyrophosphatase activity" EXACT []
synonym: "phosphoribosyladenosine triphosphate pyrophosphatase activity" EXACT [EC:3.6.1.31]
xref: EC:3.6.1.31
xref: KEGG:R04035
xref: MetaCyc:HISTPRATPHYD-RXN
xref: RHEA:22831
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0004637
name: phosphoribosylamine-glycine ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-phospho-D-ribosylamine + ATP + glycine = N(1)-(5-phospho-D-ribosyl)glycinamide + ADP + 2 H(+) + phosphate." [EC:6.3.4.13, RHEA:17456]
subset: gosubset_prok
synonym: "2-amino-N-ribosylacetamide 5'-phosphate kinosynthase activity" EXACT [EC:6.3.4.13]
synonym: "5'-phosphoribosylglycinamide synthetase activity" EXACT [EC:6.3.4.13]
synonym: "5-phospho-D-ribosylamine:glycine ligase (ADP-forming)" EXACT [EC:6.3.4.13]
synonym: "GAR" RELATED [EC:6.3.4.13]
synonym: "GAR synthetase activity" EXACT [EC:6.3.4.13]
synonym: "GARS activity" EXACT [EC:6.3.4.13]
synonym: "glycinamide ribonucleotide synthetase activity" EXACT [EC:6.3.4.13]
synonym: "glycineamide ribonucleotide synthetase activity" EXACT [EC:6.3.4.13]
synonym: "phosphoribosylglycinamide synthetase activity" EXACT [EC:6.3.4.13]
synonym: "phosphoribosylglycineamide synthetase activity" EXACT [EC:6.3.4.13]
xref: EC:6.3.4.13
xref: KEGG:R04144
xref: MetaCyc:GLYRIBONUCSYN-RXN
xref: Reactome:REACT_103071 "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi, Drosophila melanogaster"
xref: Reactome:REACT_104076 "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi, Taeniopygia guttata"
xref: Reactome:REACT_106192 "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi, Mus musculus"
xref: Reactome:REACT_108489 "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi, Gallus gallus"
xref: Reactome:REACT_115925 "5-phosphoribosylamine + glycine + ATP <=> 5-phosphoribosylglycinamide (GAR) + adenosine 5'-diphosphate + orthophosphate, Gallus gallus"
xref: Reactome:REACT_285 "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi, Homo sapiens"
xref: Reactome:REACT_28848 "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi, Canis familiaris"
xref: Reactome:REACT_29216 "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi, Arabidopsis thaliana"
xref: Reactome:REACT_77588 "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi, Danio rerio"
xref: Reactome:REACT_81216 "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi, Xenopus tropicalis"
xref: Reactome:REACT_85338 "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi, Rattus norvegicus"
xref: Reactome:REACT_86072 "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi, Saccharomyces cerevisiae"
xref: Reactome:REACT_87636 "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi, Escherichia coli"
xref: Reactome:REACT_88947 "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi, Staphylococcus aureus N315"
xref: Reactome:REACT_90292 "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi, Schizosaccharomyces pombe"
xref: Reactome:REACT_93235 "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi, Dictyostelium discoideum"
xref: Reactome:REACT_93559 "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi, Caenorhabditis elegans"
xref: Reactome:REACT_97521 "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi, Bos taurus"
xref: Reactome:REACT_99517 "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi, Mycobacterium tuberculosis"
xref: RHEA:17456
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0004638
name: phosphoribosylaminoimidazole carboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + 2 H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO(2)." [EC:4.1.1.21, RHEA:10795]
subset: gosubset_prok
synonym: "1-(5-phosphoribosyl)-5-amino-4-imidazolecarboxylate carboxy-lyase activity" EXACT [EC:4.1.1.21]
synonym: "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase [5-amino-1-(5-phospho-D-ribosyl)imidazole-forming]" RELATED [EC:4.1.1.21]
synonym: "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase activity" EXACT [EC:4.1.1.21]
synonym: "5-amino-1-ribosylimidazole 5-phosphate carboxylase activity" EXACT [EC:4.1.1.21]
synonym: "5-phosphoribosyl-5-aminoimidazole carboxylase activity" EXACT [EC:4.1.1.21]
synonym: "ADE2" RELATED [EC:4.1.1.21]
synonym: "AIR carboxylase activity" EXACT [EC:4.1.1.21]
synonym: "class II PurE" RELATED [EC:4.1.1.21]
xref: EC:4.1.1.21
xref: KEGG:R04209
xref: MetaCyc:AIRCARBOXY-RXN
xref: Reactome:REACT_105892 "AIR + CO2 => CAIR, Taeniopygia guttata"
xref: Reactome:REACT_108287 "AIR + CO2 => CAIR, Sus scrofa"
xref: Reactome:REACT_110684 "AIR + CO2 => CAIR, Gallus gallus"
xref: Reactome:REACT_110707 "AIR + CO2 => CAIR, Bos taurus"
xref: Reactome:REACT_115900 "5'-phosphoribosyl-5-aminoimidazole (AIR) + CO2 <=> 5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR), Gallus gallus"
xref: Reactome:REACT_28954 "AIR + CO2 => CAIR, Xenopus tropicalis"
xref: Reactome:REACT_29663 "AIR + CO2 => CAIR, Escherichia coli"
xref: Reactome:REACT_31451 "AIR + CO2 => CAIR, Drosophila melanogaster"
xref: Reactome:REACT_589 "AIR + CO2 => CAIR, Homo sapiens"
xref: Reactome:REACT_78332 "AIR + CO2 => CAIR, Staphylococcus aureus N315"
xref: Reactome:REACT_78854 "AIR + CO2 => CAIR, Caenorhabditis elegans"
xref: Reactome:REACT_81065 "AIR + CO2 => CAIR, Danio rerio"
xref: Reactome:REACT_87755 "AIR + CO2 => CAIR, Rattus norvegicus"
xref: Reactome:REACT_94416 "AIR + CO2 => CAIR, Canis familiaris"
xref: Reactome:REACT_97372 "AIR + CO2 => CAIR, Mus musculus"
xref: RHEA:10795
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004639
name: phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate." [EC:6.3.2.6, RHEA:22631]
subset: gosubset_prok
synonym: "4-((N-succinylamino)carbonyl)-5-aminoimidazole ribonucleotide synthetase activity" EXACT [EC:6.3.2.6]
synonym: "4-(N-succinocarboxamide)-5-aminoimidazole synthetase activity" EXACT [EC:6.3.2.6]
synonym: "4-[(N-succinylamino)carbonyl]-5-aminoimidazole ribonucleotide synthetase activity" EXACT [EC:6.3.2.6]
synonym: "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate:L-aspartate ligase (ADP-forming)" EXACT [EC:6.3.2.6]
synonym: "5-aminoimidazole-4-N-succinocarboxamide ribonucleotide synthetase activity" EXACT [EC:6.3.2.6]
synonym: "phosphoribosylaminoimidazole-succinocarboxamide synthase activity" EXACT [EC:6.3.2.6]
synonym: "phosphoribosylaminoimidazole-succinocarboxamide synthetase activity" EXACT [EC:6.3.2.6]
synonym: "phosphoribosylaminoimidazolesuccinocarboxamide synthetase activity" EXACT [EC:6.3.2.6]
synonym: "PurC" RELATED [EC:6.3.2.6]
synonym: "SAICAR synthase activity" EXACT [EC:6.3.2.6]
synonym: "SAICAR synthetase activity" EXACT [EC:6.3.2.6]
synonym: "SAICARs activity" EXACT [EC:6.3.2.6]
xref: EC:6.3.2.6
xref: KEGG:R04591
xref: MetaCyc:SAICARSYN-RXN
xref: Reactome:REACT_101197 "CAIR + Aspartate + ATP => SAICAR + ADP + Pi, Danio rerio"
xref: Reactome:REACT_105438 "CAIR + Aspartate + ATP => SAICAR + ADP + Pi, Caenorhabditis elegans"
xref: Reactome:REACT_106342 "CAIR + Aspartate + ATP => SAICAR + ADP + Pi, Mus musculus"
xref: Reactome:REACT_108 "CAIR + Aspartate + ATP => SAICAR + ADP + Pi, Homo sapiens"
xref: Reactome:REACT_108542 "CAIR + Aspartate + ATP => SAICAR + ADP + Pi, Escherichia coli"
xref: Reactome:REACT_110520 "CAIR + Aspartate + ATP => SAICAR + ADP + Pi, Staphylococcus aureus N315"
xref: Reactome:REACT_115530 "5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR) + L-aspartate + ATP => 5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) + adenosine 5'-diphosphate + orthophosphate, Gallus gallus"
xref: Reactome:REACT_28153 "CAIR + Aspartate + ATP => SAICAR + ADP + Pi, Drosophila melanogaster"
xref: Reactome:REACT_83405 "CAIR + Aspartate + ATP => SAICAR + ADP + Pi, Bos taurus"
xref: Reactome:REACT_85214 "CAIR + Aspartate + ATP => SAICAR + ADP + Pi, Sus scrofa"
xref: Reactome:REACT_86983 "CAIR + Aspartate + ATP => SAICAR + ADP + Pi, Xenopus tropicalis"
xref: Reactome:REACT_87410 "CAIR + Aspartate + ATP => SAICAR + ADP + Pi, Canis familiaris"
xref: Reactome:REACT_88991 "CAIR + Aspartate + ATP => SAICAR + ADP + Pi, Gallus gallus"
xref: Reactome:REACT_94909 "CAIR + Aspartate + ATP => SAICAR + ADP + Pi, Rattus norvegicus"
xref: Reactome:REACT_96782 "CAIR + Aspartate + ATP => SAICAR + ADP + Pi, Taeniopygia guttata"
xref: RHEA:22631
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0004640
name: phosphoribosylanthranilate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate." [EC:5.3.1.24, RHEA:21543]
subset: gosubset_prok
synonym: "IGPS:PRAI (indole-3-glycerol-phosphate synthetase/N-5'-phosphoribosylanthranilate isomerase complex)" RELATED [EC:5.3.1.24]
synonym: "N-(5'-phosphoribosyl)anthranilate isomerase activity" EXACT [EC:5.3.1.24]
synonym: "N-(5-phospho-beta-D-ribosyl)anthranilate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.24]
synonym: "N-(5-phospho-beta-D-ribosyl)anthranilate ketol-isomerase activity" EXACT [EC:5.3.1.24]
synonym: "PRA isomerase activity" EXACT [EC:5.3.1.24]
synonym: "PRAI activity" EXACT [EC:5.3.1.24]
xref: EC:5.3.1.24
xref: KEGG:R03509
xref: MetaCyc:PRAISOM-RXN
xref: RHEA:21543
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0004641
name: phosphoribosylformylglycinamidine cyclo-ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate." [EC:6.3.3.1, RHEA:23035]
subset: gosubset_prok
synonym: "2-(formamido)-1-N-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming)" EXACT [EC:6.3.3.1]
synonym: "2-(formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming)" EXACT [EC:6.3.3.1]
synonym: "5'-aminoimidazole ribonucleotide synthetase activity" EXACT [EC:6.3.3.1]
synonym: "AIR synthase activity" EXACT [EC:6.3.3.1]
synonym: "AIR synthetase activity" EXACT [EC:6.3.3.1]
synonym: "AIRS activity" EXACT [EC:6.3.3.1]
synonym: "phosphoribosyl-aminoimidazole synthetase activity" EXACT [EC:6.3.3.1]
synonym: "phosphoribosylaminoimidazole synthetase activity" EXACT [EC:6.3.3.1]
xref: EC:6.3.3.1
xref: KEGG:R04208
xref: MetaCyc:AIRS-RXN
xref: Reactome:REACT_105364 "FGAM + ATP => AIR + ADP + Pi, Xenopus tropicalis"
xref: Reactome:REACT_106728 "FGAM + ATP => AIR + ADP + Pi, Taeniopygia guttata"
xref: Reactome:REACT_115615 "5'-phosphoribosylformylglycinamidine (FGAM) + ATP => 5'-phosphoribosyl-5-aminoimidazole (AIR) + ADP + orthophosphate, Gallus gallus"
xref: Reactome:REACT_1917 "FGAM + ATP => AIR + ADP + Pi, Homo sapiens"
xref: Reactome:REACT_30018 "FGAM + ATP => AIR + ADP + Pi, Arabidopsis thaliana"
xref: Reactome:REACT_33275 "FGAM + ATP => AIR + ADP + Pi, Escherichia coli"
xref: Reactome:REACT_78085 "FGAM + ATP => AIR + ADP + Pi, Mus musculus"
xref: Reactome:REACT_81338 "FGAM + ATP => AIR + ADP + Pi, Saccharomyces cerevisiae"
xref: Reactome:REACT_82181 "FGAM + ATP => AIR + ADP + Pi, Drosophila melanogaster"
xref: Reactome:REACT_82307 "FGAM + ATP => AIR + ADP + Pi, Dictyostelium discoideum"
xref: Reactome:REACT_83744 "FGAM + ATP => AIR + ADP + Pi, Canis familiaris"
xref: Reactome:REACT_86553 "FGAM + ATP => AIR + ADP + Pi, Caenorhabditis elegans"
xref: Reactome:REACT_87634 "FGAM + ATP => AIR + ADP + Pi, Rattus norvegicus"
xref: Reactome:REACT_88385 "FGAM + ATP => AIR + ADP + Pi, Mycobacterium tuberculosis"
xref: Reactome:REACT_89870 "FGAM + ATP => AIR + ADP + Pi, Gallus gallus"
xref: Reactome:REACT_93152 "FGAM + ATP => AIR + ADP + Pi, Danio rerio"
xref: Reactome:REACT_94295 "FGAM + ATP => AIR + ADP + Pi, Staphylococcus aureus N315"
xref: Reactome:REACT_96653 "FGAM + ATP => AIR + ADP + Pi, Bos taurus"
xref: Reactome:REACT_99755 "FGAM + ATP => AIR + ADP + Pi, Schizosaccharomyces pombe"
xref: RHEA:23035
is_a: GO:0016882 ! cyclo-ligase activity

[Term]
id: GO:0004642
name: phosphoribosylformylglycinamidine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + ATP + H(2)O = 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate + ADP + 2 H(+) + phosphate." [EC:6.3.5.3, RHEA:17132]
subset: gosubset_prok
synonym: "2-N-formyl-1-N-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.3]
synonym: "5'-phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.3]
synonym: "FGAM synthase activity" EXACT [EC:6.3.5.3]
synonym: "FGAM synthetase activity" EXACT [EC:6.3.5.3]
synonym: "FGAR amidotransferase activity" EXACT [EC:6.3.5.3]
synonym: "FGARAT activity" EXACT [EC:6.3.5.3]
synonym: "formylglycinamide ribonucloetide amidotransferase activity" EXACT [EC:6.3.5.3]
synonym: "formylglycinamide ribotide amidotransferase activity" EXACT [EC:6.3.5.3]
synonym: "N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.3]
synonym: "phosphoribosylformylglycinamidine synthetase activity" EXACT [EC:6.3.5.3]
synonym: "phosphoribosylformylglycineamidine synthetase activity" EXACT [EC:6.3.5.3]
xref: EC:6.3.5.3
xref: KEGG:R04463
xref: MetaCyc:FGAMSYN-RXN
xref: Reactome:REACT_100090 "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi, Schizosaccharomyces pombe"
xref: Reactome:REACT_103088 "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi, Drosophila melanogaster"
xref: Reactome:REACT_107579 "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi, Bos taurus"
xref: Reactome:REACT_108774 "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi, Saccharomyces cerevisiae"
xref: Reactome:REACT_110503 "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi, Arabidopsis thaliana"
xref: Reactome:REACT_112941 "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi, Xenopus tropicalis"
xref: Reactome:REACT_115636 "5'-phosphoribosylformylglycinamide (FGAR) + L-glutamine + ATP + H2O => 5'-phosphoribosylformylglycinamidine (FGAM) + L-glutamate + ADP + orthophosphate, Gallus gallus"
xref: Reactome:REACT_1427 "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi, Homo sapiens"
xref: Reactome:REACT_80286 "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi, Escherichia coli"
xref: Reactome:REACT_80793 "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi, Caenorhabditis elegans"
xref: Reactome:REACT_87595 "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi, Danio rerio"
xref: Reactome:REACT_88114 "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi, Taeniopygia guttata"
xref: Reactome:REACT_92684 "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi, Rattus norvegicus"
xref: Reactome:REACT_97086 "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi, Mus musculus"
xref: Reactome:REACT_97309 "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi, Dictyostelium discoideum"
xref: Reactome:REACT_97565 "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi, Canis familiaris"
xref: RHEA:17132
is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor

[Term]
id: GO:0004643
name: phosphoribosylaminoimidazolecarboxamide formyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide = tetrahydrofolate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide." [EC:2.1.2.3]
subset: gosubset_prok
synonym: "10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazole-carboxamide N-formyltransferase activity" EXACT [EC:2.1.2.3]
synonym: "10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase activity" EXACT [EC:2.1.2.3]
synonym: "5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase activity" EXACT [EC:2.1.2.3]
synonym: "5-amino-1-ribosyl-4-imidazolecarboxamide 5'-phosphate transformylase activity" EXACT [EC:2.1.2.3]
synonym: "5-amino-4-imidazolecarboxamide ribonucleotide transformylase activity" EXACT [EC:2.1.2.3]
synonym: "5-amino-4-imidazolecarboxamide ribotide transformylase activity" EXACT [EC:2.1.2.3]
synonym: "AICAR formyltransferase activity" EXACT [EC:2.1.2.3]
synonym: "AICAR transformylase activity" EXACT [EC:2.1.2.3]
synonym: "aminoimidazolecarboxamide ribonucleotide transformylase activity" EXACT [EC:2.1.2.3]
xref: EC:2.1.2.3
xref: MetaCyc:AICARTRANSFORM-RXN
xref: Reactome:REACT_100136 "AICAR + 10-Formyl-THF => FAICAR + THF, Saccharomyces cerevisiae"
xref: Reactome:REACT_105746 "AICAR + 10-Formyl-THF => FAICAR + THF, Gallus gallus"
xref: Reactome:REACT_106017 "AICAR + 10-Formyl-THF => FAICAR + THF, Xenopus tropicalis"
xref: Reactome:REACT_106129 "AICAR + 10-Formyl-THF => FAICAR + THF, Taeniopygia guttata"
xref: Reactome:REACT_109989 "AICAR + 10-Formyl-THF => FAICAR + THF, Schizosaccharomyces pombe"
xref: Reactome:REACT_115711 "5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + 10-formyltetrahydrofolate => 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) + tetrahydrofolate, Gallus gallus"
xref: Reactome:REACT_29929 "AICAR + 10-Formyl-THF => FAICAR + THF, Oryza sativa"
xref: Reactome:REACT_33070 "AICAR + 10-Formyl-THF => FAICAR + THF, Staphylococcus aureus N315"
xref: Reactome:REACT_79901 "AICAR + 10-Formyl-THF => FAICAR + THF, Mus musculus"
xref: Reactome:REACT_812 "AICAR + 10-Formyl-THF => FAICAR + THF, Homo sapiens"
xref: Reactome:REACT_82475 "AICAR + 10-Formyl-THF => FAICAR + THF, Mycobacterium tuberculosis"
xref: Reactome:REACT_82717 "AICAR + 10-Formyl-THF => FAICAR + THF, Danio rerio"
xref: Reactome:REACT_82943 "AICAR + 10-Formyl-THF => FAICAR + THF, Arabidopsis thaliana"
xref: Reactome:REACT_83688 "AICAR + 10-Formyl-THF => FAICAR + THF, Canis familiaris"
xref: Reactome:REACT_84114 "AICAR + 10-Formyl-THF => FAICAR + THF, Drosophila melanogaster"
xref: Reactome:REACT_89291 "AICAR + 10-Formyl-THF => FAICAR + THF, Bos taurus"
xref: Reactome:REACT_91865 "AICAR + 10-Formyl-THF => FAICAR + THF, Sus scrofa"
xref: Reactome:REACT_93995 "AICAR + 10-Formyl-THF => FAICAR + THF, Escherichia coli"
xref: Reactome:REACT_96335 "AICAR + 10-Formyl-THF => FAICAR + THF, Caenorhabditis elegans"
xref: Reactome:REACT_97799 "AICAR + 10-Formyl-THF => FAICAR + THF, Rattus norvegicus"
xref: Reactome:REACT_98007 "AICAR + 10-Formyl-THF => FAICAR + THF, Dictyostelium discoideum"
xref: RHEA:22195
is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity

[Term]
id: GO:0004644
name: phosphoribosylglycinamide formyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide." [EC:2.1.2.2]
subset: gosubset_prok
synonym: "10-formyltetrahydrofolate:5'-phosphoribosylglycinamide N-formyltransferase activity" EXACT [EC:2.1.2.2]
synonym: "2-amino-N-ribosylacetamide 5'-phosphate transformylase activity" EXACT [EC:2.1.2.2]
synonym: "5'-phosphoribosylglycinamide transformylase activity" EXACT [EC:2.1.2.2]
synonym: "5,10-methenyltetrahydrofolate:2-amino-N-ribosylacetamide ribonucleotide transformylase activity" EXACT [EC:2.1.2.2]
synonym: "GAR formyltransferase activity" EXACT [EC:2.1.2.2]
synonym: "GAR TFase activity" EXACT [EC:2.1.2.2]
synonym: "GAR transformylase activity" EXACT [EC:2.1.2.2]
synonym: "GART activity" EXACT [EC:2.1.2.2]
synonym: "glycinamide ribonucleotide transformylase activity" EXACT [EC:2.1.2.2]
xref: EC:2.1.2.2
xref: MetaCyc:GART-RXN
xref: Reactome:REACT_100477 "GAR + 10-Formyl-THF => FGAR + THF, Staphylococcus aureus N315"
xref: Reactome:REACT_103634 "GAR + 10-Formyl-THF => FGAR + THF, Schizosaccharomyces pombe"
xref: Reactome:REACT_107836 "GAR + 10-Formyl-THF => FGAR + THF, Canis familiaris"
xref: Reactome:REACT_116073 "5-phosphoribosylglycinamide (GAR) + 10-formyl-tetrahydrofolate => 5'-phosphoribosylformylglycinamide (FGAR) + tetrahydrofolate, Gallus gallus"
xref: Reactome:REACT_1509 "GAR + 10-Formyl-THF => FGAR + THF, Homo sapiens"
xref: Reactome:REACT_28364 "GAR + 10-Formyl-THF => FGAR + THF, Escherichia coli"
xref: Reactome:REACT_30954 "GAR + 10-Formyl-THF => FGAR + THF, Dictyostelium discoideum"
xref: Reactome:REACT_53210 "GAR + 10-Formyl-THF => FGAR + THF, Saccharomyces cerevisiae"
xref: Reactome:REACT_80952 "GAR + 10-Formyl-THF => FGAR + THF, Arabidopsis thaliana"
xref: Reactome:REACT_84168 "GAR + 10-Formyl-THF => FGAR + THF, Rattus norvegicus"
xref: Reactome:REACT_84815 "GAR + 10-Formyl-THF => FGAR + THF, Caenorhabditis elegans"
xref: Reactome:REACT_88401 "GAR + 10-Formyl-THF => FGAR + THF, Taeniopygia guttata"
xref: Reactome:REACT_91318 "GAR + 10-Formyl-THF => FGAR + THF, Mus musculus"
xref: Reactome:REACT_91591 "GAR + 10-Formyl-THF => FGAR + THF, Danio rerio"
xref: Reactome:REACT_94851 "GAR + 10-Formyl-THF => FGAR + THF, Gallus gallus"
xref: Reactome:REACT_95189 "GAR + 10-Formyl-THF => FGAR + THF, Mycobacterium tuberculosis"
xref: Reactome:REACT_95495 "GAR + 10-Formyl-THF => FGAR + THF, Drosophila melanogaster"
xref: Reactome:REACT_97804 "GAR + 10-Formyl-THF => FGAR + THF, Xenopus tropicalis"
xref: Reactome:REACT_98595 "GAR + 10-Formyl-THF => FGAR + THF, Bos taurus"
xref: RHEA:15056
is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity

[Term]
id: GO:0004645
name: phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + phosphate = 1,4-alpha-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate. The name should be qualified in each instance by adding the name of the natural substrate, e.g. maltodextrin phosphorylase, starch phosphorylase, glycogen phosphorylase." [EC:2.4.1.1]
subset: gosubset_prok
synonym: "1,4-alpha-D-glucan:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.1]
synonym: "1,4-alpha-glucan phosphorylase activity" EXACT [EC:2.4.1.1]
synonym: "alpha-glucan phosphorylase" BROAD [EC:2.4.1.1]
synonym: "amylopectin phosphorylase" NARROW [EC:2.4.1.1]
synonym: "amylophosphorylase activity" NARROW [EC:2.4.1.1]
synonym: "glucan phosphorylase" NARROW [EC:2.4.1.1]
synonym: "glucosan phosphorylase" NARROW [EC:2.4.1.1]
synonym: "granulose phosphorylase" NARROW [EC:2.4.1.1]
synonym: "muscle phosphorylase" NARROW [EC:2.4.1.1]
synonym: "muscle phosphorylase a and b activity" NARROW [EC:2.4.1.1]
synonym: "myophosphorylase" NARROW [EC:2.4.1.1]
synonym: "polyphosphorylase activity" EXACT [EC:2.4.1.1]
synonym: "potato phosphorylase" NARROW [EC:2.4.1.1]
synonym: "starch phosphorylase" NARROW [EC:2.4.1.1]
xref: EC:2.4.1.1
xref: MetaCyc:RXN-1826
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0004647
name: phosphoserine phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: L(or D)-O-phosphoserine + H2O = L(or D)-serine + phosphate." [EC:3.1.3.3]
subset: gosubset_prok
synonym: "O-phosphoserine phosphohydrolase activity" EXACT [EC:3.1.3.3]
xref: EC:3.1.3.3
xref: MetaCyc:PSERPHOSPHA-RXN
xref: Reactome:REACT_115834 "phosphoserine is dephosphorylated, Homo sapiens"
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0004648
name: O-phospho-L-serine:2-oxoglutarate aminotransferase activity
namespace: molecular_function
alt_id: GO:0004646
def: "Catalysis of the reaction: O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate." [EC:2.6.1.52]
subset: gosubset_prok
synonym: "3-O-phospho-L-serine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.52]
synonym: "3-phosphoserine aminotransferase activity" EXACT [EC:2.6.1.52]
synonym: "3PHP transaminase activity" EXACT [EC:2.6.1.52]
synonym: "hydroxypyruvic phosphate--glutamic transaminase activity" EXACT [EC:2.6.1.52]
synonym: "L-phosphoserine aminotransferase activity" EXACT [EC:2.6.1.52]
synonym: "PdxC" RELATED [EC:2.6.1.52]
synonym: "phosphohydroxypyruvate transaminase activity" EXACT [EC:2.6.1.52]
synonym: "phosphohydroxypyruvic--glutamic transaminase activity" EXACT [EC:2.6.1.52]
synonym: "phosphoserine aminotransferase activity" BROAD []
synonym: "phosphoserine transaminase activity" BROAD [EC:2.6.1.52]
synonym: "PSAT activity" EXACT [EC:2.6.1.52]
synonym: "SerC" RELATED [EC:2.6.1.52]
xref: EC:2.6.1.52
xref: MetaCyc:PSERTRANSAM-RXN
xref: Reactome:REACT_116056 "3-phosphonooxypyruvic acid + L-glutamate = O-phospho-L-serine + 2-oxoglutarate, Homo sapiens"
xref: RHEA:14332
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0004649
name: poly(ADP-ribose) glycohydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose." [EC:3.2.1.143]
xref: EC:3.2.1.143
xref: MetaCyc:3.2.1.143-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0004650
name: polygalacturonase activity
namespace: molecular_function
def: "Catalysis of the random hydrolysis of (1->4)-alpha-D-galactosiduronic linkages in pectate and other galacturonans." [EC:3.2.1.15]
subset: gosubset_prok
synonym: "endo-D-galacturonase activity" EXACT []
synonym: "endo-polygalacturonase activity" EXACT []
synonym: "endogalacturonase activity" EXACT []
synonym: "endopolygalacturonase activity" EXACT []
synonym: "pectin depolymerase activity" NARROW [EC:3.2.1.15]
synonym: "pectin hydrolase activity" EXACT [EC:3.2.1.15]
synonym: "pectin polygalacturonase activity" EXACT [EC:3.2.1.15]
synonym: "pectinase activity" NARROW [EC:3.2.1.15]
synonym: "pectolase activity" EXACT [EC:3.2.1.15]
synonym: "poly(1,4-alpha-D-galacturonide) glycanohydrolase activity" EXACT []
synonym: "poly-alpha-1,4-galacturonide glycanohydrolase activity" EXACT []
xref: EC:3.2.1.15
xref: MetaCyc:RXN-2103
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0004651
name: polynucleotide 5'-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5'-phosphopolynucleotide + H2O = polynucleotide + phosphate." [EC:3.1.3.33]
synonym: "5'-polynucleotidase activity" EXACT [EC:3.1.3.33]
synonym: "polynucleotide 5'-phosphohydrolase activity" EXACT [EC:3.1.3.33]
synonym: "polynucleotide 5'-triphosphatase activity" EXACT [EC:3.1.3.33]
xref: EC:3.1.3.33
xref: MetaCyc:POLYNUCLEOTIDE-5-PHOSPHATASE-RXN
xref: Reactome:REACT_105600 "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme, Xenopus tropicalis"
xref: Reactome:REACT_1368 "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme, Homo sapiens"
xref: Reactome:REACT_29083 "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme, Danio rerio"
xref: Reactome:REACT_29917 "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme, Saccharomyces cerevisiae"
xref: Reactome:REACT_30977 "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme, Schizosaccharomyces pombe"
xref: Reactome:REACT_31847 "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme, Rattus norvegicus"
xref: Reactome:REACT_78922 "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme, Caenorhabditis elegans"
xref: Reactome:REACT_79151 "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme, Mus musculus"
xref: Reactome:REACT_81068 "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme, Drosophila melanogaster"
xref: Reactome:REACT_81973 "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme, Dictyostelium discoideum"
xref: Reactome:REACT_82462 "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme, Gallus gallus"
xref: Reactome:REACT_84900 "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme, Bos taurus"
xref: Reactome:REACT_85239 "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme, Arabidopsis thaliana"
xref: Reactome:REACT_92870 "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme, Canis familiaris"
xref: Reactome:REACT_94470 "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme, Oryza sativa"
is_a: GO:0098518 ! polynucleotide phosphatase activity
relationship: part_of GO:0098507 ! polynucleotide 5' dephosphorylation

[Term]
id: GO:0004652
name: polynucleotide adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group." [EC:2.7.7.19]
subset: gosubset_prok
synonym: "adenosine triphosphate:ribonucleic acid adenylyltransferase activity" EXACT [EC:2.7.7.19]
synonym: "AMP polynucleotidylexotransferase activity" EXACT [EC:2.7.7.19]
synonym: "ATP-polynucleotide adenylyltransferase activity" EXACT [EC:2.7.7.19]
synonym: "ATP:polynucleotide adenylyltransferase activity" EXACT [EC:2.7.7.19]
synonym: "ATP:polynucleotidylexotransferase activity" EXACT [EC:2.7.7.19]
synonym: "NTP polymerase activity" EXACT [EC:2.7.7.19]
synonym: "poly(A) hydrolase activity" EXACT [EC:2.7.7.19]
synonym: "poly(A) polymerase activity" EXACT [EC:2.7.7.19]
synonym: "poly(A) synthetase activity" EXACT [EC:2.7.7.19]
synonym: "poly-A polymerase activity" EXACT [EC:2.7.7.19]
synonym: "polyadenylate nucleotidyltransferase activity" EXACT [EC:2.7.7.19]
synonym: "polyadenylate polymerase activity" EXACT [EC:2.7.7.19]
synonym: "polyadenylate synthetase activity" EXACT [EC:2.7.7.19]
synonym: "polyadenylic acid polymerase activity" EXACT [EC:2.7.7.19]
synonym: "polyadenylic polymerase activity" EXACT [EC:2.7.7.19]
synonym: "RNA adenylating enzyme activity" EXACT [EC:2.7.7.19]
synonym: "RNA formation factors, PF1" RELATED [EC:2.7.7.19]
synonym: "terminal riboadenylate transferase activity" EXACT [EC:2.7.7.19]
xref: EC:2.7.7.19
xref: MetaCyc:POLYNUCLEOTIDE-ADENYLYLTRANSFERASE-RXN
xref: Reactome:REACT_101055 "mRNA polyadenylation, Mus musculus"
xref: Reactome:REACT_108244 "mRNA polyadenylation, Bos taurus"
xref: Reactome:REACT_111985 "mRNA polyadenylation, Arabidopsis thaliana"
xref: Reactome:REACT_112181 "mRNA polyadenylation, Caenorhabditis elegans"
xref: Reactome:REACT_113637 "mRNA polyadenylation, Oryza sativa"
xref: Reactome:REACT_113649 "mRNA polyadenylation, Drosophila melanogaster"
xref: Reactome:REACT_1162 "mRNA polyadenylation, Homo sapiens"
xref: Reactome:REACT_29515 "mRNA polyadenylation, Xenopus tropicalis"
xref: Reactome:REACT_82496 "mRNA polyadenylation, Danio rerio"
xref: Reactome:REACT_99672 "mRNA polyadenylation, Canis familiaris"
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0004653
name: polypeptide N-acetylgalactosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis." [EC:2.4.1.41, ISBN:0879695595]
synonym: "glycoprotein acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41]
synonym: "polypeptide-N-acetylgalactosamine transferase activity" EXACT [EC:2.4.1.41]
synonym: "protein-UDP acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41]
synonym: "UDP-acetylgalactosamine-glycoprotein acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41]
synonym: "UDP-acetylgalactosamine:peptide-N-galactosaminyltransferase activity" EXACT [EC:2.4.1.41]
synonym: "UDP-GalNAc:polypeptide N-acetylgalactosaminyl transferase activity" EXACT [EC:2.4.1.41]
synonym: "UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41]
synonym: "UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41]
synonym: "UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyl-transferase activity" EXACT [EC:2.4.1.41]
synonym: "UDP-N-acetylgalactosamine-glycoprotein N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41]
synonym: "UDP-N-acetylgalactosamine-protein N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41]
synonym: "UDP-N-acetylgalactosamine:kappa-casein polypeptide N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41]
synonym: "UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41]
synonym: "UDP-N-acetylgalactosamine:protein N-acetylgalactosaminyl transferase activity" EXACT [EC:2.4.1.41]
synonym: "uridine diphosphoacetylgalactosamine-glycoprotein acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41]
xref: EC:2.4.1.41
xref: MetaCyc:2.4.1.41-RXN
xref: Reactome:REACT_115586 "Addition of GalNAc to mucins to form the Tn antigen, Homo sapiens"
is_a: GO:0008376 ! acetylgalactosaminyltransferase activity

[Term]
id: GO:0004654
name: polyribonucleotide nucleotidyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + RNA(n) = diphosphate + RNA(n+1)." [EC:2.7.7.8]
subset: gosubset_prok
synonym: "nucleoside diphosphate:polynucleotidyl transferase activity" EXACT [EC:2.7.7.8]
synonym: "polynucleotide phosphorylase activity" EXACT [EC:2.7.7.8]
synonym: "polyribonucleotide phosphorylase activity" EXACT [EC:2.7.7.8]
synonym: "polyribonucleotide:phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.8]
xref: EC:2.7.7.8
xref: MetaCyc:2.7.7.8-RXN
is_a: GO:0016779 ! nucleotidyltransferase activity

[Term]
id: GO:0004655
name: porphobilinogen synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 5-aminolevulinate = 2 H(2)O + H(+) + porphobilinogen." [EC:4.2.1.24, RHEA:24067]
subset: gosubset_prok
synonym: "5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing)" EXACT [EC:4.2.1.24]
synonym: "5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing; porphobilinogen-forming)" EXACT [EC:4.2.1.24]
synonym: "5-levulinic acid dehydratase activity" EXACT [EC:4.2.1.24]
synonym: "aminolevulinate dehydratase activity" EXACT []
synonym: "aminolevulinic dehydratase activity" EXACT [EC:4.2.1.24]
synonym: "delta-aminolevulinate dehydratase activity" EXACT [EC:4.2.1.24]
synonym: "delta-aminolevulinic acid dehydrase activity" EXACT [EC:4.2.1.24]
synonym: "delta-aminolevulinic acid dehydratase activity" EXACT []
synonym: "delta-aminolevulinic dehydratase activity" EXACT [EC:4.2.1.24]
xref: EC:4.2.1.24
xref: KEGG:R00036
xref: MetaCyc:PORPHOBILSYNTH-RXN
xref: Reactome:REACT_102149 "Two molecules of ALA condense to form porphobilinogen (PBG), Plasmodium falciparum"
xref: Reactome:REACT_105735 "Two molecules of ALA condense to form porphobilinogen (PBG), Mycobacterium tuberculosis"
xref: Reactome:REACT_107315 "Two molecules of ALA condense to form porphobilinogen (PBG), Bos taurus"
xref: Reactome:REACT_108067 "Two molecules of ALA condense to form porphobilinogen (PBG), Canis familiaris"
xref: Reactome:REACT_108366 "Two molecules of ALA condense to form porphobilinogen (PBG), Schizosaccharomyces pombe"
xref: Reactome:REACT_109551 "Two molecules of ALA condense to form porphobilinogen (PBG), Taeniopygia guttata"
xref: Reactome:REACT_115799 "2 delta-aminolevulinate => porphobilinogen + 2 H2O, Gallus gallus"
xref: Reactome:REACT_28521 "Two molecules of ALA condense to form porphobilinogen (PBG), Danio rerio"
xref: Reactome:REACT_30060 "Two molecules of ALA condense to form porphobilinogen (PBG), Escherichia coli"
xref: Reactome:REACT_34582 "Two molecules of ALA condense to form porphobilinogen (PBG), Rattus norvegicus"
xref: Reactome:REACT_78417 "Two molecules of ALA condense to form porphobilinogen (PBG), Gallus gallus"
xref: Reactome:REACT_86208 "Two molecules of ALA condense to form porphobilinogen (PBG), Saccharomyces cerevisiae"
xref: Reactome:REACT_86506 "Two molecules of ALA condense to form porphobilinogen (PBG), Mus musculus"
xref: Reactome:REACT_87228 "Two molecules of ALA condense to form porphobilinogen (PBG), Staphylococcus aureus N315"
xref: Reactome:REACT_87418 "Two molecules of ALA condense to form porphobilinogen (PBG), Xenopus tropicalis"
xref: Reactome:REACT_91105 "Two molecules of ALA condense to form porphobilinogen (PBG), Arabidopsis thaliana"
xref: Reactome:REACT_93306 "Two molecules of ALA condense to form porphobilinogen (PBG), Oryza sativa"
xref: Reactome:REACT_9430 "Two molecules of ALA condense to form porphobilinogen (PBG), Homo sapiens"
xref: Reactome:REACT_95615 "Two molecules of ALA condense to form porphobilinogen (PBG), Drosophila melanogaster"
xref: Reactome:REACT_95858 "Two molecules of ALA condense to form porphobilinogen (PBG), Dictyostelium discoideum"
xref: RHEA:24067
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0004656
name: procollagen-proline 4-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2." [EC:1.14.11.2]
synonym: "collagen proline hydroxylase activity" EXACT [EC:1.14.11.2]
synonym: "hydroxylase, collagen proline activity" EXACT [EC:1.14.11.2]
synonym: "peptidyl proline hydroxylase activity" BROAD [EC:1.14.11.2]
synonym: "procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) activity" EXACT [EC:1.14.11.2]
synonym: "procollagen-proline,2-oxoglutarate-4-dioxygenase activity" EXACT []
synonym: "proline hydroxylase activity" BROAD [EC:1.14.11.2]
synonym: "proline protocollagen hydroxylase activity" EXACT [EC:1.14.11.2]
synonym: "proline, 2-oxoglutarate dioxygenase activity" BROAD [EC:1.14.11.2]
synonym: "proline,2-oxoglutarate 4-dioxygenase activity" BROAD [EC:1.14.11.2]
synonym: "prolyl 4-hydroxylase activity" BROAD [EC:1.14.11.2]
synonym: "prolyl hydroxylase activity" BROAD [EC:1.14.11.2]
synonym: "prolyl-glycyl-peptide, 2-oxoglutarate:oxygen oxidoreductase, 4-hydroxylating activity" BROAD [EC:1.14.11.2]
synonym: "prolylprotocollagen dioxygenase activity" EXACT [EC:1.14.11.2]
synonym: "prolylprotocollagen hydroxylase activity" EXACT [EC:1.14.11.2]
synonym: "protocollagen hydroxylase activity" BROAD [EC:1.14.11.2]
synonym: "protocollagen proline 4-hydroxylase activity" EXACT [EC:1.14.11.2]
synonym: "protocollagen proline dioxygenase activity" EXACT [EC:1.14.11.2]
synonym: "protocollagen proline hydroxylase activity" EXACT [EC:1.14.11.2]
synonym: "protocollagen prolyl hydroxylase activity" EXACT [EC:1.14.11.2]
xref: EC:1.14.11.2
xref: KEGG:R03219
xref: MetaCyc:1.14.11.2-RXN
is_a: GO:0019798 ! procollagen-proline dioxygenase activity
is_a: GO:0031545 ! peptidyl-proline 4-dioxygenase activity

[Term]
id: GO:0004657
name: proline dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor." [EC:1.5.99.8]
subset: gosubset_prok
synonym: "L-proline dehydrogenase activity" EXACT [EC:1.5.99.8]
synonym: "L-proline:(acceptor) oxidoreductase activity" EXACT [EC:1.5.99.8]
synonym: "L-proline:acceptor oxidoreductase activity" EXACT [EC:1.5.99.8]
xref: EC:1.5.99.8
xref: MetaCyc:RXN-7181
xref: Reactome:REACT_101312 "proline => L-1-pyrroline-5-carboxylate, Dictyostelium discoideum"
xref: Reactome:REACT_103832 "proline => L-1-pyrroline-5-carboxylate, Danio rerio"
xref: Reactome:REACT_107246 "proline => L-1-pyrroline-5-carboxylate, Xenopus tropicalis"
xref: Reactome:REACT_1563 "proline => L-1-pyrroline-5-carboxylate, Homo sapiens"
xref: Reactome:REACT_28732 "proline => L-1-pyrroline-5-carboxylate, Caenorhabditis elegans"
xref: Reactome:REACT_29283 "proline => L-1-pyrroline-5-carboxylate, Drosophila melanogaster"
xref: Reactome:REACT_30776 "proline => L-1-pyrroline-5-carboxylate, Mus musculus"
xref: Reactome:REACT_31152 "proline => L-1-pyrroline-5-carboxylate, Canis familiaris"
xref: Reactome:REACT_32543 "proline => L-1-pyrroline-5-carboxylate, Arabidopsis thaliana"
xref: Reactome:REACT_33712 "proline => L-1-pyrroline-5-carboxylate, Rattus norvegicus"
xref: Reactome:REACT_54319 "proline => L-1-pyrroline-5-carboxylate, Gallus gallus"
xref: Reactome:REACT_78247 "proline => L-1-pyrroline-5-carboxylate, Oryza sativa"
xref: Reactome:REACT_79850 "proline => L-1-pyrroline-5-carboxylate, Taeniopygia guttata"
xref: RHEA:23787
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0004658
name: propionyl-CoA carboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA." [EC:6.4.1.3]
subset: gosubset_prok
synonym: "PCCase activity" EXACT [EC:6.4.1.3]
synonym: "propanoyl-CoA:carbon-dioxide ligase (ADP-forming)" EXACT [EC:6.4.1.3]
synonym: "propionyl coenzyme A carboxylase activity" EXACT [EC:6.4.1.3]
xref: EC:6.4.1.3
xref: MetaCyc:PROPIONYL-COA-CARBOXY-RXN
xref: Reactome:REACT_100940 "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate, Canis familiaris"
xref: Reactome:REACT_102253 "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_106327 "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate, Taeniopygia guttata"
xref: Reactome:REACT_107916 "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate, Danio rerio"
xref: Reactome:REACT_28834 "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate, Bos taurus"
xref: Reactome:REACT_51611 "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate, Rattus norvegicus"
xref: Reactome:REACT_580 "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate, Homo sapiens"
xref: Reactome:REACT_78168 "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate, Caenorhabditis elegans"
xref: Reactome:REACT_83417 "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate, Gallus gallus"
xref: Reactome:REACT_84170 "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate, Xenopus tropicalis"
xref: Reactome:REACT_97504 "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate, Mus musculus"
xref: Reactome:REACT_98587 "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate, Sus scrofa"
xref: RHEA:23723
is_a: GO:0016421 ! CoA carboxylase activity

[Term]
id: GO:0004659
name: prenyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor)." [GOC:mah]
subset: gosubset_prok
xref: EC:2.5.1.-
xref: MetaCyc:GPPSYN-RXN
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0004660
name: protein farnesyltransferase activity
namespace: molecular_function
alt_id: GO:0018223
def: "Catalysis of the reaction: farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate." [EC:2.5.1.58, PMID:8621375]
comment: The catalyzed reaction transfers a farnesyl group from farnesyl diphosphate to a target protein.  There is no relationship between this activity and farnesyltransferase activity, GO:0004311, where the catalyzed reaction forms (free) geranylgeranyl diphosphate.
synonym: "CAAX farnesyltransferase activity" NARROW [EC:2.5.1.58]
synonym: "farnesyl-diphosphate:protein-cysteine farnesyltransferase activity" EXACT [EC:2.5.1.58]
synonym: "FTase activity" EXACT [EC:2.5.1.58]
synonym: "protein-cysteine farnesyltransferase activity" EXACT []
xref: EC:2.5.1.58
xref: MetaCyc:2.5.1.58-RXN
is_a: GO:0008318 ! protein prenyltransferase activity

[Term]
id: GO:0004661
name: protein geranylgeranyltransferase activity
namespace: molecular_function
alt_id: GO:0018224
def: "Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein." [PMID:8621375]
synonym: "protein-cysteine geranylgeranyltransferase activity" EXACT []
xref: EC:2.5.1.-
is_a: GO:0008318 ! protein prenyltransferase activity

[Term]
id: GO:0004662
name: CAAX-protein geranylgeranyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families." [EC:2.5.1.59, PMID:8621375]
synonym: "geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity" EXACT []
synonym: "geranylgeranyltransferase type I activity" EXACT []
synonym: "GGTase-I activity" EXACT []
synonym: "GGTaseI activity" EXACT []
synonym: "protein geranylgeranyltransferase type I" RELATED [EC:2.5.1.59]
synonym: "type I protein geranyl-geranyltransferase activity" EXACT [EC:2.5.1.59]
xref: EC:2.5.1.59
xref: MetaCyc:2.5.1.60-RXN
xref: MetaCyc:RXN-3701
is_a: GO:0004661 ! protein geranylgeranyltransferase activity

[Term]
id: GO:0004663
name: Rab geranylgeranyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family." [EC:2.5.1.60, GOC:mah, PMID:8621375]
synonym: "geranylgeranyl-diphosphate,geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity" EXACT []
synonym: "GGTase-II activity" EXACT []
synonym: "GGTaseII activity" EXACT []
synonym: "protein geranylgeranyltransferase type II activity" EXACT []
synonym: "Rab-protein geranylgeranyltransferase activity" EXACT []
synonym: "RabGGTase activity" EXACT []
synonym: "type II protein geranyl-geranyltransferase activity" EXACT [EC:2.5.1.60]
xref: EC:2.5.1.60
xref: MetaCyc:2.5.1.60-RXN
xref: MetaCyc:RXN-3701
is_a: GO:0004661 ! protein geranylgeranyltransferase activity

[Term]
id: GO:0004664
name: prephenate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: prephenate = phenylpyruvate + H2O + CO2." [EC:4.2.1.51]
subset: gosubset_prok
synonym: "prephenate hydro-lyase (decarboxylating)" EXACT [EC:4.2.1.51]
synonym: "prephenate hydro-lyase (decarboxylating; phenylpyruvate-forming)" EXACT [EC:4.2.1.51]
xref: EC:4.2.1.51
xref: MetaCyc:PREPHENATEDEHYDRAT-RXN
xref: RHEA:21651
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0004665
name: prephenate dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP(+) + prephenate = (4-hydroxyphenyl)pyruvate + CO(2) + NADPH." [EC:1.3.1.13, RHEA:21643]
subset: gosubset_prok
synonym: "prephenate (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT [EC:1.3.1.13]
synonym: "prephenate:NADP+ oxidoreductase (decarboxylating)" EXACT [EC:1.3.1.13]
xref: EC:1.3.1.13
xref: KEGG:R01730
xref: MetaCyc:PREPHENATE-DEHYDROGENASE-NADP+-RXN
xref: RHEA:21643
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004666
name: prostaglandin-endoperoxide synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O." [EC:1.14.99.1]
synonym: "(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase activity" EXACT [EC:1.14.99.1]
synonym: "(PG)H synthase activity" EXACT [EC:1.14.99.1]
synonym: "fatty acid cyclooxygenase activity" EXACT [EC:1.14.99.1]
synonym: "PG synthetase activity" EXACT [EC:1.14.99.1]
synonym: "prostaglandin endoperoxide synthetase activity" EXACT [EC:1.14.99.1]
synonym: "prostaglandin G/H synthase activity" EXACT [EC:1.14.99.1]
synonym: "prostaglandin synthase activity" EXACT [EC:1.14.99.1]
synonym: "prostaglandin synthetase activity" EXACT [EC:1.14.99.1]
xref: EC:1.14.99.1
xref: MetaCyc:PROSTAGLANDIN-ENDOPEROXIDE-SYNTHASE-RXN
xref: Reactome:REACT_100937 "Arachidonic acid oxidised to PGG2, Mus musculus"
xref: Reactome:REACT_30504 "Arachidonic acid oxidised to PGG2, Sus scrofa"
xref: Reactome:REACT_44300 "Arachidonic acid oxidised to PGG2, Canis familiaris"
xref: Reactome:REACT_528 "Arachidonic acid oxidised to PGG2, Homo sapiens"
xref: Reactome:REACT_85880 "Arachidonic acid oxidised to PGG2, Bos taurus"
xref: Reactome:REACT_87094 "Arachidonic acid oxidised to PGG2, Rattus norvegicus"
xref: Reactome:REACT_94563 "Arachidonic acid oxidised to PGG2, Xenopus tropicalis"
xref: Reactome:REACT_94683 "Arachidonic acid oxidised to PGG2, Danio rerio"
xref: Reactome:REACT_95206 "Arachidonic acid oxidised to PGG2, Gallus gallus"
xref: Reactome:REACT_98023 "Arachidonic acid oxidised to PGG2, Taeniopygia guttata"
xref: RHEA:23731
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0004667
name: prostaglandin-D synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: prostaglandin H(2) = prostaglandin D(2)." [EC:5.3.99.2, RHEA:10603]
synonym: "(5,13)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate D-isomerase activity" EXACT [EC:5.3.99.2]
synonym: "PGD2 synthase activity" EXACT [EC:5.3.99.2]
synonym: "PGH-PGD isomerase activity" EXACT [EC:5.3.99.2]
synonym: "prostaglandin D2 synthase activity" EXACT [EC:5.3.99.2]
synonym: "prostaglandin-H2 D-isomerase activity" EXACT [EC:5.3.99.2]
synonym: "prostaglandin-R-prostaglandin D isomerase activity" EXACT [EC:5.3.99.2]
xref: EC:5.3.99.2
xref: KEGG:R02266
xref: MetaCyc:PROSTAGLANDIN-D-SYNTHASE-RXN
xref: RHEA:10603
is_a: GO:0016860 ! intramolecular oxidoreductase activity

[Term]
id: GO:0004668
name: protein-arginine deiminase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein L-arginine + H2O = protein L-citrulline + NH3." [EC:3.5.3.15]
subset: gosubset_prok
synonym: "peptidylarginine deiminase activity" EXACT [EC:3.5.3.15]
synonym: "protein-L-arginine iminohydrolase activity" EXACT [EC:3.5.3.15]
xref: EC:3.5.3.15
xref: MetaCyc:PROTEIN-ARGININE-DEIMINASE-RXN
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0004671
name: protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
namespace: molecular_function
alt_id: GO:0018225
def: "Catalysis of the reaction: S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester." [EC:2.1.1.100]
subset: gosubset_prok
synonym: "farnesyl cysteine C-terminal methyltransferase activity" EXACT [EC:2.1.1.100]
synonym: "farnesyl-protein carboxymethyltransferase activity" EXACT [EC:2.1.1.100]
synonym: "farnesylated protein C-terminal O-methyltransferase activity" EXACT [EC:2.1.1.100]
synonym: "isoprenylated protein methyltransferase activity" EXACT [EC:2.1.1.100]
synonym: "isoprenylcysteine carboxylmethyltransferase activity" RELATED [EC:2.1.1.100]
synonym: "prenylated protein carboxyl methyltransferase activity" EXACT [EC:2.1.1.100]
synonym: "prenylated protein methyltransferase activity" EXACT [EC:2.1.1.100]
synonym: "prenylcysteine carboxyl methyltransferase activity" RELATED [EC:2.1.1.100]
synonym: "prenylcysteine carboxylmethyltransferase activity" EXACT [EC:2.1.1.100]
synonym: "prenylcysteine carboxymethyltransferase activity" EXACT [EC:2.1.1.100]
synonym: "prenylcysteine methyltransferase activity" EXACT [EC:2.1.1.100]
synonym: "protein C-terminal farnesylcysteine O-methyltransferase activity" EXACT [EC:2.1.1.100]
synonym: "protein S-farnesylcysteine C-terminal methyltransferase activity" EXACT [EC:2.1.1.100]
synonym: "protein-S-isoprenylcysteine O-methyltransferase activity" EXACT []
synonym: "S-adenosyl-L-methionine:protein-C-terminal-S-farnesyl-L-cysteine O-methyltransferase activity" EXACT [EC:2.1.1.100]
synonym: "S-farnesylcysteine methyltransferase activity" EXACT [EC:2.1.1.100]
xref: EC:2.1.1.100
xref: KEGG:R04496
xref: MetaCyc:2.1.1.100-RXN
is_a: GO:0003880 ! protein C-terminal carboxyl O-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0004672
name: protein kinase activity
namespace: molecular_function
alt_id: GO:0050222
def: "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
comment: Note that triphosphate is used as a phosphate donor by at least one kinase.
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_metagenomics
subset: gosubset_prok
synonym: "protamine kinase activity" NARROW []
xref: MetaCyc:PROTEIN-KINASE-RXN
xref: Reactome:REACT_100389 "Phosphorylation and Release of IRF3 or IRF7, Bos taurus"
xref: Reactome:REACT_100723 "Phosphorylation of p130Cas by SRC-FADK1 complex, Canis familiaris"
xref: Reactome:REACT_100866 "Phosphorylation and activation of Ezrin, Gallus gallus"
xref: Reactome:REACT_101171 "Phosphorylation and release of IRF3/IRF7, Rattus norvegicus"
xref: Reactome:REACT_101316 "Autophosphorylation of FADK1 at Y397, Rattus norvegicus"
xref: Reactome:REACT_102340 "Activated Src activates ERK, Danio rerio"
xref: Reactome:REACT_102368 "Phosphorylation and Release of IRF3 or IRF7, Gallus gallus"
xref: Reactome:REACT_104931 "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer, Gallus gallus"
xref: Reactome:REACT_104987 "Phosphorylation of pFADK1 by SRC, Danio rerio"
xref: Reactome:REACT_105344 "Phosphorylation of p130Cas by SRC-FADK1 complex, Sus scrofa"
xref: Reactome:REACT_106425 "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer, Taeniopygia guttata"
xref: Reactome:REACT_106633 "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer, Sus scrofa"
xref: Reactome:REACT_107161 "Phosphorylation and release of IRF3/IRF7, Taeniopygia guttata"
xref: Reactome:REACT_107646 "Phosphorylation and release of IRF3/IRF7, Canis familiaris"
xref: Reactome:REACT_107914 "(Frs2)Rap1-GTP binds to and activates B-Raf, Xenopus tropicalis"
xref: Reactome:REACT_108319 "Activated Src activates ERK, Xenopus tropicalis"
xref: Reactome:REACT_108693 "Phosphorylation and release of IRF3/IRF7, Mus musculus"
xref: Reactome:REACT_109624 "Phosphorylation of p130Cas by SRC-FADK1 complex, Rattus norvegicus"
xref: Reactome:REACT_110105 "Phosphorylation and activation of Ezrin, Canis familiaris"
xref: Reactome:REACT_110177 "Autophosphorylation of FADK1 at Y397, Mus musculus"
xref: Reactome:REACT_110248 "Activated Src activates ERK, Canis familiaris"
xref: Reactome:REACT_111075 "Phosphorylation of LIN52 component of MuvB by DYRK1A, Homo sapiens"
xref: Reactome:REACT_111995 "Phosphorylation of p130Cas by SRC-FADK1 complex, Drosophila melanogaster"
xref: Reactome:REACT_112267 "Autophosphorylation of FADK1 at Y397, Drosophila melanogaster"
xref: Reactome:REACT_112918 "Phosphorylation and activation of Ezrin, Caenorhabditis elegans"
xref: Reactome:REACT_113100 "Activated Src activates ERK, Drosophila melanogaster"
xref: Reactome:REACT_113334 "PKC phosphorylates GRK2, Caenorhabditis elegans"
xref: Reactome:REACT_113440 "Phosphorylation and release of IRF3/IRF7, Xenopus tropicalis"
xref: Reactome:REACT_113589 "Phosphorylation of pFADK1 by SRC, Drosophila melanogaster"
xref: Reactome:REACT_113821 "Activated Src activates ERK, Caenorhabditis elegans"
xref: Reactome:REACT_114093 "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer, Danio rerio"
xref: Reactome:REACT_114693 "Phosphorylation of pFADK1 by SRC, Xenopus tropicalis"
xref: Reactome:REACT_115673 "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR, Homo sapiens"
xref: Reactome:REACT_115712 "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers, Homo sapiens"
xref: Reactome:REACT_115868 "Phosphorylation of c-Abl and Arg by ATM, Gallus gallus"
xref: Reactome:REACT_116057 "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1, Homo sapiens"
xref: Reactome:REACT_116116 "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3, Homo sapiens"
xref: Reactome:REACT_12050 "(Frs2)Rap1-GTP binds to and activates B-Raf, Homo sapiens"
xref: Reactome:REACT_1325 "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer, Homo sapiens"
xref: Reactome:REACT_15368 "Phosphorylation of pFADK1 by SRC, Homo sapiens"
xref: Reactome:REACT_15375 "Phosphorylation of p130Cas by SRC-FADK1 complex, Homo sapiens"
xref: Reactome:REACT_15534 "PKC phosphorylates GRK2, Homo sapiens"
xref: Reactome:REACT_15535 "Autophosphorylation of FADK1 at Y397, Homo sapiens"
xref: Reactome:REACT_161 "rLkb-1 (Stk-11) activates AMPK by phosphorylation, Rattus norvegicus"
xref: Reactome:REACT_1825 "INF-gamma induced phosphorylation of L13a, Homo sapiens"
xref: Reactome:REACT_19374 "Phosphorylation of Plexin-A, Mus musculus"
xref: Reactome:REACT_22301 "Phosphorylation and activation of Ezrin, Homo sapiens"
xref: Reactome:REACT_22305 "Phosphorylation of FADK1, Mus musculus"
xref: Reactome:REACT_23900 "Activated Src activates ERK, Homo sapiens"
xref: Reactome:REACT_24935 "Activation of IKK by MEKK1, Homo sapiens"
xref: Reactome:REACT_25200 "IRAK1 phosphorylates Pellino, Homo sapiens"
xref: Reactome:REACT_25213 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:Mal:activated TLR complex, Homo sapiens"
xref: Reactome:REACT_25241 "IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation, Homo sapiens"
xref: Reactome:REACT_25327 "Phosphorylation and release of IRF7, Homo sapiens"
xref: Reactome:REACT_25368 "Phosphorylation and release of IRF3/IRF7, Homo sapiens"
xref: Reactome:REACT_27151 "Multiple IRAK1 autophosphorylation within the complex p-IRAK4:oligo MyD88:activated TLR, Homo sapiens"
xref: Reactome:REACT_27163 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR complex, Homo sapiens"
xref: Reactome:REACT_27165 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex, Homo sapiens"
xref: Reactome:REACT_27228 "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR, Homo sapiens"
xref: Reactome:REACT_29590 "PKC phosphorylates GRK2, Rattus norvegicus"
xref: Reactome:REACT_29816 "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer, Drosophila melanogaster"
xref: Reactome:REACT_30885 "Phosphorylation of p130Cas by SRC-FADK1 complex, Bos taurus"
xref: Reactome:REACT_31028 "Autophosphorylation of FADK1 at Y397, Sus scrofa"
xref: Reactome:REACT_31157 "Phosphorylation of pFADK1 by SRC, Canis familiaris"
xref: Reactome:REACT_31403 "Autophosphorylation of FADK1 at Y397, Gallus gallus"
xref: Reactome:REACT_32448 "Phosphorylation of pFADK1 by SRC, Bos taurus"
xref: Reactome:REACT_32744 "PKC phosphorylates GRK2, Mus musculus"
xref: Reactome:REACT_33098 "PKC phosphorylates GRK2, Canis familiaris"
xref: Reactome:REACT_33973 "Phosphorylation and Release of IRF3 or IRF7, Canis familiaris"
xref: Reactome:REACT_34630 "(Frs2)Rap1-GTP binds to and activates B-Raf, Danio rerio"
xref: Reactome:REACT_6227 "Activated DTOR also phosphorylates D4EBP, Drosophila melanogaster"
xref: Reactome:REACT_6236 "Activated DTOR phosphorylates DS6K, Drosophila melanogaster"
xref: Reactome:REACT_6842 "Phosphorylation and Release of IRF3 or IRF7, Homo sapiens"
xref: Reactome:REACT_6862 "Multiple IRAK1 autophosphorylation steps, Homo sapiens"
xref: Reactome:REACT_72123 "PKC phosphorylates GRK2, Sus scrofa"
xref: Reactome:REACT_75763 "Phosphorylation and release of IRF3, Gallus gallus"
xref: Reactome:REACT_75767 "Phosphorylation of IKKs complex mediated by MEKK1, Gallus gallus"
xref: Reactome:REACT_77320 "Phosphorylation and release of IRF3/IRF7, Gallus gallus"
xref: Reactome:REACT_77352 "Phosphorylation of p130Cas by SRC-FADK1 complex, Danio rerio"
xref: Reactome:REACT_78568 "Phosphorylation and activation of Ezrin, Danio rerio"
xref: Reactome:REACT_79546 "Activated Src activates ERK, Gallus gallus"
xref: Reactome:REACT_80382 "Phosphorylation and activation of Ezrin, Mus musculus"
xref: Reactome:REACT_81116 "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer, Canis familiaris"
xref: Reactome:REACT_81601 "Autophosphorylation of FADK1 at Y397, Bos taurus"
xref: Reactome:REACT_81960 "PKC phosphorylates GRK2, Drosophila melanogaster"
xref: Reactome:REACT_82440 "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer, Xenopus tropicalis"
xref: Reactome:REACT_82942 "Activated Src activates ERK, Bos taurus"
xref: Reactome:REACT_83498 "Activated Src activates ERK, Taeniopygia guttata"
xref: Reactome:REACT_83992 "(Frs2)Rap1-GTP binds to and activates B-Raf, Mus musculus"
xref: Reactome:REACT_84298 "Autophosphorylation of FADK1 at Y397, Danio rerio"
xref: Reactome:REACT_84426 "Phosphorylation and Release of IRF3 or IRF7, Taeniopygia guttata"
xref: Reactome:REACT_85334 "PKC phosphorylates GRK2, Bos taurus"
xref: Reactome:REACT_85934 "Autophosphorylation of FADK1 at Y397, Canis familiaris"
xref: Reactome:REACT_86784 "Autophosphorylation of FADK1 at Y397, Taeniopygia guttata"
xref: Reactome:REACT_86846 "Activated Src activates ERK, Mus musculus"
xref: Reactome:REACT_87050 "Phosphorylation of pFADK1 by SRC, Mus musculus"
xref: Reactome:REACT_87514 "Phosphorylation and activation of Ezrin, Sus scrofa"
xref: Reactome:REACT_87874 "Phosphorylation of pFADK1 by SRC, Sus scrofa"
xref: Reactome:REACT_87926 "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer, Bos taurus"
xref: Reactome:REACT_88017 "PKC phosphorylates GRK2, Taeniopygia guttata"
xref: Reactome:REACT_88090 "Phosphorylation and release of IRF3/IRF7, Bos taurus"
xref: Reactome:REACT_88178 "Phosphorylation and release of IRF3/IRF7, Sus scrofa"
xref: Reactome:REACT_88344 "(Frs2)Rap1-GTP binds to and activates B-Raf, Sus scrofa"
xref: Reactome:REACT_88685 "Phosphorylation of p130Cas by SRC-FADK1 complex, Xenopus tropicalis"
xref: Reactome:REACT_89390 "(Frs2)Rap1-GTP binds to and activates B-Raf, Bos taurus"
xref: Reactome:REACT_90060 "Autophosphorylation of FADK1 at Y397, Xenopus tropicalis"
xref: Reactome:REACT_90671 "Phosphorylation and activation of Ezrin, Xenopus tropicalis"
xref: Reactome:REACT_90879 "Phosphorylation of p130Cas by SRC-FADK1 complex, Gallus gallus"
xref: Reactome:REACT_91096 "Activated Src activates ERK, Sus scrofa"
xref: Reactome:REACT_93160 "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer, Mus musculus"
xref: Reactome:REACT_93476 "(Frs2)Rap1-GTP binds to and activates B-Raf, Canis familiaris"
xref: Reactome:REACT_93547 "Activated Src activates ERK, Rattus norvegicus"
xref: Reactome:REACT_94091 "Phosphorylation and activation of Ezrin, Bos taurus"
xref: Reactome:REACT_95384 "Phosphorylation and Release of IRF3 or IRF7, Mus musculus"
xref: Reactome:REACT_96044 "Phosphorylation of p130Cas by SRC-FADK1 complex, Mus musculus"
xref: Reactome:REACT_96155 "Phosphorylation and release of IRF3/IRF7, Danio rerio"
xref: Reactome:REACT_96307 "Phosphorylation and Release of IRF3 or IRF7, Danio rerio"
xref: Reactome:REACT_96320 "Phosphorylation and activation of Ezrin, Rattus norvegicus"
xref: Reactome:REACT_96822 "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer, Dictyostelium discoideum"
xref: Reactome:REACT_96873 "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer, Caenorhabditis elegans"
xref: Reactome:REACT_97267 "PKC phosphorylates GRK2, Gallus gallus"
xref: Reactome:REACT_97501 "(Frs2)Rap1-GTP binds to and activates B-Raf, Taeniopygia guttata"
xref: Reactome:REACT_97784 "Phosphorylation and activation of Ezrin, Taeniopygia guttata"
xref: Reactome:REACT_98334 "Phosphorylation of pFADK1 by SRC, Rattus norvegicus"
xref: Reactome:REACT_98994 "(Frs2)Rap1-GTP binds to and activates B-Raf, Gallus gallus"
xref: Reactome:REACT_99274 "Phosphorylation of p130Cas by SRC-FADK1 complex, Taeniopygia guttata"
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
relationship: part_of GO:0006468 ! protein phosphorylation

[Term]
id: GO:0004673
name: protein histidine kinase activity
namespace: molecular_function
alt_id: GO:0008896
def: "Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine." [EC:2.7.13.3, GOC:mah]
subset: gosubset_prok
synonym: "ATP:protein-L-histidine N-phosphotransferase activity" EXACT [EC:2.7.13.3]
synonym: "EnvZ" NARROW [EC:2.7.13.3]
synonym: "histidine kinase (ambiguous)" EXACT [EC:2.7.13.3]
synonym: "histidine kinase activity" EXACT []
synonym: "histidine protein kinase (ambiguous)" EXACT [EC:2.7.13.3]
synonym: "histidine protein kinase activity" EXACT [EC:2.7.13.3]
synonym: "HK1" RELATED [EC:2.7.13.3]
synonym: "HP165" RELATED [EC:2.7.13.3]
synonym: "protein histidine kinase (ambiguous)" EXACT [EC:2.7.13.3]
synonym: "protein kinase (histidine)" EXACT [EC:2.7.13.3]
synonym: "protein kinase (histidine) (ambiguous)" EXACT [EC:2.7.13.3]
synonym: "protein-histidine kinase activity" EXACT []
synonym: "Sln1p" NARROW [EC:2.7.13.3]
xref: EC:2.7.13.3
xref: MetaCyc:2.7.13.3-RXN
is_a: GO:0004672 ! protein kinase activity
is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor
relationship: part_of GO:0018106 ! peptidyl-histidine phosphorylation

[Term]
id: GO:0004674
name: protein serine/threonine kinase activity
namespace: molecular_function
alt_id: GO:0004695
alt_id: GO:0004696
alt_id: GO:0004700
def: "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
subset: gosubset_prok
synonym: "protein kinase (phosphorylating) activity" NARROW [EC:2.7.11.1]
synonym: "protein phosphokinase activity" NARROW [EC:2.7.11.1]
synonym: "protein serine kinase activity" NARROW [EC:2.7.11.1]
synonym: "protein serine-threonine kinase activity" EXACT [EC:2.7.11.1]
synonym: "protein-serine kinase activity" NARROW [EC:2.7.11.1]
synonym: "serine kinase activity" NARROW [EC:2.7.11.1]
synonym: "serine protein kinase activity" NARROW [EC:2.7.11.1]
synonym: "serine(threonine) protein kinase activity" EXACT [EC:2.7.11.1]
synonym: "serine-specific protein kinase activity" NARROW [EC:2.7.11.1]
synonym: "serine/threonine protein kinase activity" EXACT [EC:2.7.11.1]
synonym: "threonine-specific protein kinase activity" NARROW [EC:2.7.11.1]
xref: EC:2.7.11
xref: Reactome:REACT_100117 "Phosphorylation of eIF2-alpha by PERK, Xenopus tropicalis"
xref: Reactome:REACT_100192 "AKT phosphorylates IKKalpha, Canis familiaris"
xref: Reactome:REACT_100209 "ERK1/2/5 activate RSK1/2/3, Canis familiaris"
xref: Reactome:REACT_100224 "Activation of cytosolic AMPK by phosphorylation, Bos taurus"
xref: Reactome:REACT_100446 "Activation of cytosolic AMPK by phosphorylation, Rattus norvegicus"
xref: Reactome:REACT_100588 "ERK5 activates the transcription factor MEF2, Xenopus tropicalis"
xref: Reactome:REACT_100590 "AKT phosphorylates IKKalpha, Xenopus tropicalis"
xref: Reactome:REACT_100784 "AKT phosphorylates IKKalpha, Rattus norvegicus"
xref: Reactome:REACT_100870 "Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex, Bos taurus"
xref: Reactome:REACT_100918 "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding, Mus musculus"
xref: Reactome:REACT_100989 "Autophosphorylation of IRE1 dimer, Saccharomyces cerevisiae"
xref: Reactome:REACT_101264 "Phosphorylated MAPKs phosphorylate ATF-2, Sus scrofa"
xref: Reactome:REACT_101280 "Activation of claspin, Xenopus tropicalis"
xref: Reactome:REACT_101291 "Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex, Danio rerio"
xref: Reactome:REACT_101497 "Activation of claspin, Bos taurus"
xref: Reactome:REACT_101896 "ERK1/2 phosphorylates MSK1, Canis familiaris"
xref: Reactome:REACT_101920 "Inactivation of MEK1 by p34cdc2, Drosophila melanogaster"
xref: Reactome:REACT_101930 "Inactivation of MEK1 by p34cdc2, Caenorhabditis elegans"
xref: Reactome:REACT_102053 "MEK1 phosphorylates ERK-1, Saccharomyces cerevisiae"
xref: Reactome:REACT_102074 "AKT phosphorylates caspase-9, Mus musculus"
xref: Reactome:REACT_102078 "Phosphorylation of Cdc25C at Ser 216 by Chk1, Canis familiaris"
xref: Reactome:REACT_102096 "Activation of cytosolic AMPK by phosphorylation, Gallus gallus"
xref: Reactome:REACT_102133 "Phosphorylated MAPKs phosphorylate ATF-2, Mus musculus"
xref: Reactome:REACT_102370 "AKT can phosphorylate NUR77, Mus musculus"
xref: Reactome:REACT_102455 "Active p38 MAPK phosphorylates MAPKAPK2 or 3, Canis familiaris"
xref: Reactome:REACT_102500 "AKT can phosphorylate RSK, Rattus norvegicus"
xref: Reactome:REACT_102718 "Active p38 MAPK phosphorylates MAPKAPK2 or 3, Bos taurus"
xref: Reactome:REACT_102778 "ERK1/2/5 activate RSK1/2/3, Gallus gallus"
xref: Reactome:REACT_102791 "Activation of NF-kB complex, Xenopus tropicalis"
xref: Reactome:REACT_102943 "Phosphorylated MAPKs phosphorylate ATF-2, Rattus norvegicus"
xref: Reactome:REACT_102975 "LIM kinase phosphorylation by ROCK, Danio rerio"
xref: Reactome:REACT_103109 "Phosphorylation of CRMPs by Cdk5, Xenopus tropicalis"
xref: Reactome:REACT_103162 "Myosin regulatory light chain phosphorylation by ROCK, Xenopus tropicalis"
xref: Reactome:REACT_103217 "Phosphorylation of PKC theta, Xenopus tropicalis"
xref: Reactome:REACT_103304 "Phosphorylation of FANCI by ATM/ATR, Danio rerio"
xref: Reactome:REACT_103449 "PDK1 phosphorylates AKT at T308, Caenorhabditis elegans"
xref: Reactome:REACT_103541 "Activated TAK1 mediates phosphorylation of the IKK Complex, Sus scrofa"
xref: Reactome:REACT_103596 "MEK1 phosphorylates ERK-1, Bos taurus"
xref: Reactome:REACT_103658 "Phosphorylation of MARCKS by Protein kinase C, alpha type, Bos taurus"
xref: Reactome:REACT_103882 "Phosphorylation of CRY and PER Proteins, Sus scrofa"
xref: Reactome:REACT_104102 "Active p38 MAPK phosphorylates MAPKAPK2 or 3, Mus musculus"
xref: Reactome:REACT_104121 "LIM kinase phosphorylation by ROCK, Drosophila melanogaster"
xref: Reactome:REACT_104145 "PDK1 phosphorylates AKT at T308, Canis familiaris"
xref: Reactome:REACT_104284 "Active p38 MAPK phosphorylates MAPKAPK2 or 3, Xenopus tropicalis"
xref: Reactome:REACT_104288 "Phosphorylation of FANCI by ATM/ATR, Drosophila melanogaster"
xref: Reactome:REACT_104416 "ERK1/2 activates ELK1, Canis familiaris"
xref: Reactome:REACT_104521 "MEK1 phosphorylates ERK-1, Mus musculus"
xref: Reactome:REACT_104525 "Phosphorylation of PKC theta, Taeniopygia guttata"
xref: Reactome:REACT_104547 "Recruitment and activation of Chk1, Gallus gallus"
xref: Reactome:REACT_104549 "Phosphorylation of Bcl10, Gallus gallus"
xref: Reactome:REACT_104564 "AKT phosphorylates caspase-9, Bos taurus"
xref: Reactome:REACT_104874 "Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9, Mus musculus"
xref: Reactome:REACT_104906 "Myosin regulatory light chain phosphorylation by ROCK, Mus musculus"
xref: Reactome:REACT_104932 "AKT can phosphorylate NUR77, Canis familiaris"
xref: Reactome:REACT_104985 "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP, Rattus norvegicus"
xref: Reactome:REACT_105016 "p38MAPK phosphorylates MSK1, Saccharomyces cerevisiae"
xref: Reactome:REACT_105038 "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP, Sus scrofa"
xref: Reactome:REACT_105077 "Phosphorylation of MARCKS by Protein kinase C, alpha type, Mus musculus"
xref: Reactome:REACT_105298 "Activation of IKK complex, Danio rerio"
xref: Reactome:REACT_105447 "Phosphorylation of CARMA1, Xenopus tropicalis"
xref: Reactome:REACT_105470 "Phosphorylation of FANCD2 by ATR/ATM, Gallus gallus"
xref: Reactome:REACT_105502 "AKT interacts and phosphorylates Cot, Taeniopygia guttata"
xref: Reactome:REACT_105534 "p38MAPK phosphorylates MSK1, Drosophila melanogaster"
xref: Reactome:REACT_105602 "MSK1 activates CREB, Sus scrofa"
xref: Reactome:REACT_105625 "AKT can phosphorylate forkhead box transcription factors, Canis familiaris"
xref: Reactome:REACT_105894 "PKA phosphorylates CREB, Canis familiaris"
xref: Reactome:REACT_106015 "Phosphorylation of Bcl10, Bos taurus"
xref: Reactome:REACT_106033 "ERK1/2/5 activate RSK1/2/3, Danio rerio"
xref: Reactome:REACT_106141 "AKT phosphorylates IKKalpha, Bos taurus"
xref: Reactome:REACT_106200 "PKA phosphorylates CREB, Danio rerio"
xref: Reactome:REACT_106255 "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP, Mus musculus"
xref: Reactome:REACT_106263 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9, Bos taurus"
xref: Reactome:REACT_106338 "ERK1/2/5 activate RSK1/2/3, Xenopus tropicalis"
xref: Reactome:REACT_106350 "Phosphorylation of CRY and PER Proteins, Xenopus tropicalis"
xref: Reactome:REACT_106414 "CERT + ATP => monophospho-CERT + ADP, Taeniopygia guttata"
xref: Reactome:REACT_106418 "IRAK is activated, Canis familiaris"
xref: Reactome:REACT_106434 "Activation of claspin, Canis familiaris"
xref: Reactome:REACT_106501 "Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9, Canis familiaris"
xref: Reactome:REACT_106556 "Activation of TAK1-TAB2 complex, Xenopus tropicalis"
xref: Reactome:REACT_106557 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9, Taeniopygia guttata"
xref: Reactome:REACT_106566 "Phosphorylation of CARMA1, Rattus norvegicus"
xref: Reactome:REACT_106589 "MEK1 phosphorylates ERK-1, Schizosaccharomyces pombe"
xref: Reactome:REACT_106643 "Autophosphorylation of IRE1 dimer, Danio rerio"
xref: Reactome:REACT_106685 "Myosin regulatory light chain phosphorylation by ROCK, Rattus norvegicus"
xref: Reactome:REACT_106700 "AKT phosphorylates PRAS40, Rattus norvegicus"
xref: Reactome:REACT_106730 "Phosphorylation of Cdc25C at Ser 216 by Chk1, Mus musculus"
xref: Reactome:REACT_106732 "Recruitment and activation of Chk1, Canis familiaris"
xref: Reactome:REACT_106789 "Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9, Rattus norvegicus"
xref: Reactome:REACT_106853 "Phosphorylation of MARCKS by Protein kinase C, alpha type, Rattus norvegicus"
xref: Reactome:REACT_106862 "Phosphorylation of MARCKS by Protein kinase C, alpha type, Xenopus tropicalis"
xref: Reactome:REACT_106985 "Phosphorylation of LIMK-1 by PAK, Danio rerio"
xref: Reactome:REACT_107087 "IKKbeta is activated, Bos taurus"
xref: Reactome:REACT_107170 "Phosphorylation of cofilin by LIMK-1, Canis familiaris"
xref: Reactome:REACT_107216 "MSK1 activates CREB, Rattus norvegicus"
xref: Reactome:REACT_107249 "Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9, Danio rerio"
xref: Reactome:REACT_107265 "Phosphorylation of eIF2-alpha by PERK, Bos taurus"
xref: Reactome:REACT_107488 "Phosphorylation of L1 by p90rsk, Gallus gallus"
xref: Reactome:REACT_107608 "Phosphorylation of CRMPs by GSK3beta, Sus scrofa"
xref: Reactome:REACT_107764 "Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex, Rattus norvegicus"
xref: Reactome:REACT_107768 "Transphosphorylation of pLIMK1, Mus musculus"
xref: Reactome:REACT_107779 "AKT phosphorylates p21Cip1 and p27Kip1, Rattus norvegicus"
xref: Reactome:REACT_107780 "TORC2 (mTOR) phosphorylates AKT at S473, Canis familiaris"
xref: Reactome:REACT_1078 "hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP, Homo sapiens"
xref: Reactome:REACT_108016 "ALOX5 is phosphorylated by MAPKAP2, Gallus gallus"
xref: Reactome:REACT_108133 "Active p38 MAPK phosphorylates MAPKAPK2 or 3, Rattus norvegicus"
xref: Reactome:REACT_108154 "Phosphorylation of FANCD2 by ATR/ATM, Oryza sativa"
xref: Reactome:REACT_108328 "Phosphorylation of CRMPs by GSK3beta, Bos taurus"
xref: Reactome:REACT_108433 "Autophosphorylation of PAK, Taeniopygia guttata"
xref: Reactome:REACT_108435 "CERT + ATP => monophospho-CERT + ADP, Gallus gallus"
xref: Reactome:REACT_108461 "Recruitment and activation of Chk1, Bos taurus"
xref: Reactome:REACT_108511 "p38MAPK phosphorylates MSK1, Danio rerio"
xref: Reactome:REACT_108538 "MAPKAPK2 phosphorylates CREB at Serine 133, Sus scrofa"
xref: Reactome:REACT_108605 "PKA phosphorylates CREB, Mus musculus"
xref: Reactome:REACT_108670 "MEK2 phosphorylates ERK-2, Gallus gallus"
xref: Reactome:REACT_108671 "ALOX5 is phosphorylated by MAPKAP2, Mus musculus"
xref: Reactome:REACT_108839 "Transphosphorylation of pLIMK1, Dictyostelium discoideum"
xref: Reactome:REACT_108994 "Phosphorylation of cPLA2 by MAPK p38 alpha, Taeniopygia guttata"
xref: Reactome:REACT_109076 "MEK2 phosphorylates ERK-2, Danio rerio"
xref: Reactome:REACT_109135 "Active p38 MAPK phosphorylates MAPKAPK2 or 3, Taeniopygia guttata"
xref: Reactome:REACT_109768 "Phosphorylation of Cdc25C at Ser 216 by Chk1, Rattus norvegicus"
xref: Reactome:REACT_109859 "p38MAPK phosphorylates MSK1, Mus musculus"
xref: Reactome:REACT_110031 "Phosphorylation of L1 by p90rsk, Danio rerio"
xref: Reactome:REACT_110083 "Autophosphorylation of PAK, Gallus gallus"
xref: Reactome:REACT_110087 "MAPKAPK2 phosphorylates CREB at Serine 133, Bos taurus"
xref: Reactome:REACT_110094 "AKT can phosphorylate RSK, Taeniopygia guttata"
xref: Reactome:REACT_110138 "Inactivation of MEK1 by p34cdc2, Taeniopygia guttata"
xref: Reactome:REACT_110166 "AKT can phosphorylate forkhead box transcription factors, Xenopus tropicalis"
xref: Reactome:REACT_110216 "ERK1/2 phosphorylates MSK1, Mus musculus"
xref: Reactome:REACT_110270 "Autophosphorylation of IRE1 dimer, Canis familiaris"
xref: Reactome:REACT_110312 "Phosphorylation of FANCI by ATM/ATR, Mus musculus"
xref: Reactome:REACT_110374 "Phosphorylated MAPKs phosphorylate ATF-2, Gallus gallus"
xref: Reactome:REACT_110431 "Phosphorylation of FANCD2 by ATR/ATM, Sus scrofa"
xref: Reactome:REACT_110457 "Myosin regulatory light chain phosphorylation by ROCK, Danio rerio"
xref: Reactome:REACT_110470 "Phosphorylation of L1 by p90rsk, Canis familiaris"
xref: Reactome:REACT_110479 "AKT phosphorylates TSC2, inhibiting it, Mus musculus"
xref: Reactome:REACT_110532 "Inactivation of MEK1 by p34cdc2, Danio rerio"
xref: Reactome:REACT_110554 "MEK1 phosphorylates ERK-1, Drosophila melanogaster"
xref: Reactome:REACT_110695 "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP, Caenorhabditis elegans"
xref: Reactome:REACT_110719 "Phosphorylation of CARMA1, Gallus gallus"
xref: Reactome:REACT_110757 "Autophosphorylation of PAK, Rattus norvegicus"
xref: Reactome:REACT_110789 "MAP kinase activates MAPKAPK2, MAPKAPK3 and MSK1, Sus scrofa"
xref: Reactome:REACT_110890 "Phosphorylation of cPLA2 by MAPK p38 alpha, Danio rerio"
xref: Reactome:REACT_110921 "Activation of TAK1-TAB2 complex, Sus scrofa"
xref: Reactome:REACT_110930 "ERK1/2 phosphorylates MSK1, Saccharomyces cerevisiae"
xref: Reactome:REACT_111058 "Phosphorylation of Smad2 by Nodal Receptor, Homo sapiens"
xref: Reactome:REACT_111063 "SPRY2 is phosphorylated by phosphorylated MNK1, Homo sapiens"
xref: Reactome:REACT_111068 "ACVR2A/B (ActRIIA/B) Phosphorylates ACVR1B (ActRIB, ALK4) in Response to Activin, Homo sapiens"
xref: Reactome:REACT_111117 "p-MEK phosphorylates ERK, Homo sapiens"
xref: Reactome:REACT_111130 "Type II Activin Receptor (ActRIIB/ACVR2B) Phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in Response to NODAL, Homo sapiens"
xref: Reactome:REACT_111131 "Type II Activin Receptor (ActRII/ACVR2) Phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in Response to NODAL, Homo sapiens"
xref: Reactome:REACT_111138 "Phosphorylation of R-SMAD2/3 by NODAL Receptor, Homo sapiens"
xref: Reactome:REACT_111196 "PKC alpha interacts with and phosphorylates KIT, Homo sapiens"
xref: Reactome:REACT_11174 "Phosphorylation of Cyclin D1 on Thr-286 by GSK-3 beta, Mus musculus"
xref: Reactome:REACT_11183 "Activation of cytosolic AMPK by phosphorylation, Homo sapiens"
xref: Reactome:REACT_111939 "Activated TAK1 mediates phosphorylation of the IKK Complex, Xenopus tropicalis"
xref: Reactome:REACT_111972 "Autophosphorylation of IRE1 dimer, Arabidopsis thaliana"
xref: Reactome:REACT_112003 "Phosphorylation of PKC theta, Saccharomyces cerevisiae"
xref: Reactome:REACT_112061 "Phosphorylation of Cdc25C at Ser 216 by Chk1, Schizosaccharomyces pombe"
xref: Reactome:REACT_112107 "AKT phosphorylates caspase-9, Gallus gallus"
xref: Reactome:REACT_112321 "Phosphorylation of L1 by p90rsk, Schizosaccharomyces pombe"
xref: Reactome:REACT_112392 "AKT phosphorylates FOXO1A, Canis familiaris"
xref: Reactome:REACT_112393 "AKT phosphorylates p21Cip1 and p27Kip1, Gallus gallus"
xref: Reactome:REACT_112404 "Inactivation of MEK1 by p34cdc2, Saccharomyces cerevisiae"
xref: Reactome:REACT_112488 "Inactivation of MEK1 by p34cdc2, Schizosaccharomyces pombe"
xref: Reactome:REACT_112501 "Phosphorylation of L1 by p90rsk, Saccharomyces cerevisiae"
xref: Reactome:REACT_112505 "TORC2 (mTOR) phosphorylates AKT at S473, Schizosaccharomyces pombe"
xref: Reactome:REACT_112514 "Activation of IKK complex, Xenopus tropicalis"
xref: Reactome:REACT_112516 "TORC2 (mTOR) phosphorylates AKT at S473, Saccharomyces cerevisiae"
xref: Reactome:REACT_112550 "AKT phosphorylates GSK3, Schizosaccharomyces pombe"
xref: Reactome:REACT_112561 "AKT phosphorylates FOXO1A, Bos taurus"
xref: Reactome:REACT_112583 "AKT phosphorylates GSK3, Gallus gallus"
xref: Reactome:REACT_112607 "AKT can phosphorylate RSK, Schizosaccharomyces pombe"
xref: Reactome:REACT_112628 "AKT phosphorylates FOXO1A, Taeniopygia guttata"
xref: Reactome:REACT_112928 "Autophosphorylation of IRE1 dimer, Xenopus tropicalis"
xref: Reactome:REACT_112965 "AKT can phosphorylate RSK, Saccharomyces cerevisiae"
xref: Reactome:REACT_113006 "ERK1/2 phosphorylates MSK1, Oryza sativa"
xref: Reactome:REACT_113045 "AKT phosphorylates FOXO1A, Drosophila melanogaster"
xref: Reactome:REACT_113059 "Autophosphorylation of IRE1 dimer, Dictyostelium discoideum"
xref: Reactome:REACT_113062 "CERT + ATP => monophospho-CERT + ADP, Sus scrofa"
xref: Reactome:REACT_113187 "ERK1/2 phosphorylates MSK1, Dictyostelium discoideum"
xref: Reactome:REACT_113199 "Activation of NF-kB complex, Taeniopygia guttata"
xref: Reactome:REACT_113389 "AKT phosphorylates FOXO1A, Mus musculus"
xref: Reactome:REACT_113424 "PDK1 phosphorylates AKT at T308, Gallus gallus"
xref: Reactome:REACT_113479 "ERK1/2 activates ELK1, Taeniopygia guttata"
xref: Reactome:REACT_113486 "AKT phosphorylates TSC2, inhibiting it, Gallus gallus"
xref: Reactome:REACT_113508 "AKT phosphorylates GSK3, Drosophila melanogaster"
xref: Reactome:REACT_113549 "ERK1/2/5 activate RSK1/2/3, Oryza sativa"
xref: Reactome:REACT_113560 "AKT interacts and phosphorylates Cot, Gallus gallus"
xref: Reactome:REACT_113575 "MEK1 phosphorylates ERK-1, Arabidopsis thaliana"
xref: Reactome:REACT_113600 "Phosphorylation of PKC theta, Schizosaccharomyces pombe"
xref: Reactome:REACT_113619 "PDK1 phosphorylates AKT at T308, Saccharomyces cerevisiae"
xref: Reactome:REACT_113634 "Activated TAK1 mediates phosphorylation of the IKK Complex, Drosophila melanogaster"
xref: Reactome:REACT_113693 "MEK1 phosphorylates ERK-1, Oryza sativa"
xref: Reactome:REACT_113717 "AKT can phosphorylate NUR77, Drosophila melanogaster"
xref: Reactome:REACT_113719 "ERK1/2 phosphorylates MSK1, Schizosaccharomyces pombe"
xref: Reactome:REACT_113729 "AKT phosphorylates TSC2, inhibiting it, Schizosaccharomyces pombe"
xref: Reactome:REACT_113732 "p38MAPK phosphorylates MSK1, Arabidopsis thaliana"
xref: Reactome:REACT_113744 "ERK1/2/5 activate RSK1/2/3, Schizosaccharomyces pombe"
xref: Reactome:REACT_113764 "Phosphorylation of cofilin by LIMK-1, Danio rerio"
xref: Reactome:REACT_113794 "Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex, Xenopus tropicalis"
xref: Reactome:REACT_113810 "Phosphorylation of Bcl10, Xenopus tropicalis"
xref: Reactome:REACT_113830 "MEK1 phosphorylates ERK-1, Dictyostelium discoideum"
xref: Reactome:REACT_113835 "Transphosphorylation of pLIMK1, Taeniopygia guttata"
xref: Reactome:REACT_113900 "CERT + ATP => monophospho-CERT + ADP, Caenorhabditis elegans"
xref: Reactome:REACT_113949 "p38MAPK phosphorylates MSK1, Schizosaccharomyces pombe"
xref: Reactome:REACT_114044 "Autophosphorylation of IRE1 dimer, Oryza sativa"
xref: Reactome:REACT_114079 "PDK1 phosphorylates AKT at T308, Schizosaccharomyces pombe"
xref: Reactome:REACT_114092 "AKT phosphorylates CREB, Gallus gallus"
xref: Reactome:REACT_114136 "hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP, Caenorhabditis elegans"
xref: Reactome:REACT_114306 "ERK1/2 phosphorylates MSK1, Arabidopsis thaliana"
xref: Reactome:REACT_114321 "AKT phosphorylates IKKalpha, Gallus gallus"
xref: Reactome:REACT_114322 "AKT phosphorylates FOXO1A, Rattus norvegicus"
xref: Reactome:REACT_114335 "MSK1 activates CREB, Xenopus tropicalis"
xref: Reactome:REACT_114476 "p38MAPK phosphorylates MSK1, Dictyostelium discoideum"
xref: Reactome:REACT_114479 "AKT can phosphorylate NUR77, Caenorhabditis elegans"
xref: Reactome:REACT_114548 "AKT phosphorylates MDM2, Gallus gallus"
xref: Reactome:REACT_114581 "AKT can phosphorylate forkhead box transcription factors, Gallus gallus"
xref: Reactome:REACT_114650 "ERK1/2 phosphorylates MSK1, Xenopus tropicalis"
xref: Reactome:REACT_114660 "ERK1/2 activates ELK1, Xenopus tropicalis"
xref: Reactome:REACT_114718 "ERK1/2 activates ELK1, Caenorhabditis elegans"
xref: Reactome:REACT_114782 "ERK1/2/5 activate RSK1/2/3, Dictyostelium discoideum"
xref: Reactome:REACT_114835 "AKT can phosphorylate forkhead box transcription factors, Drosophila melanogaster"
xref: Reactome:REACT_114899 "MSK1 activates ATF1, Xenopus tropicalis"
xref: Reactome:REACT_114971 "Phosphorylation of MARCKS by Protein kinase C, alpha type, Drosophila melanogaster"
xref: Reactome:REACT_115073 "TORC2 (mTOR) phosphorylates AKT at S473, Gallus gallus"
xref: Reactome:REACT_115253 "p38MAPK phosphorylates MSK1, Xenopus tropicalis"
xref: Reactome:REACT_115290 "p38MAPK phosphorylates MSK1, Oryza sativa"
xref: Reactome:REACT_115293 "Phosphorylation of Cdc25C at Ser 216 by Chk1, Saccharomyces cerevisiae"
xref: Reactome:REACT_115340 "AKT phosphorylates FOXO1A, Gallus gallus"
xref: Reactome:REACT_115364 "CERT + ATP => monophospho-CERT + ADP, Drosophila melanogaster"
xref: Reactome:REACT_115391 "ERK1/2/5 activate RSK1/2/3, Arabidopsis thaliana"
xref: Reactome:REACT_115462 "Phosphorylation of Cdc25C at Ser 216 by Chk1, Caenorhabditis elegans"
xref: Reactome:REACT_115474 "AKT phosphorylates BAD, Xenopus tropicalis"
xref: Reactome:REACT_115576 "Phosphorylation of NBS1 by ATM, Gallus gallus"
xref: Reactome:REACT_115647 "Phosphorylation of FANCG at S7, Gallus gallus"
xref: Reactome:REACT_115840 "Phosphorylation of Chk1 by ATM upon DNA damage, Gallus gallus"
xref: Reactome:REACT_115981 "Phosphorylation of RPA2 by CDC2 kinase, Gallus gallus"
xref: Reactome:REACT_115987 "Phosphorylation of Chk1 by ATR, Gallus gallus"
xref: Reactome:REACT_116006 "PKA phosphorylates CREB, Rattus norvegicus"
xref: Reactome:REACT_116016 "Phosphorylation of Chk2 by ATM upon DNA damage, Gallus gallus"
xref: Reactome:REACT_116065 "Phosphorylation of USP8 by P-AKT, Homo sapiens"
xref: Reactome:REACT_1170 "Phosphorylation of Cdc25C at Ser 216 by Chk1, Homo sapiens"
xref: Reactome:REACT_12032 "MAP kinase activates MAPKAPK2, MAPKAPK3 and MSK1, Homo sapiens"
xref: Reactome:REACT_12383 "AKT phosphorylates PRAS40, Homo sapiens"
xref: Reactome:REACT_12391 "TORC2 (mTOR) phosphorylates AKT at S473, Homo sapiens"
xref: Reactome:REACT_12395 "AKT phosphorylates caspase-9, Homo sapiens"
xref: Reactome:REACT_12399 "Activation of NF-kB complex, Homo sapiens"
xref: Reactome:REACT_12406 "ERK1/2 activates ELK1, Homo sapiens"
xref: Reactome:REACT_12413 "ERK5 activates the transcription factor MEF2, Homo sapiens"
xref: Reactome:REACT_12416 "ERK1/2 activates ELK1, Mus musculus"
xref: Reactome:REACT_12420 "AKT phosphorylates p21Cip1 and p27Kip1, Homo sapiens"
xref: Reactome:REACT_12429 "Akt1 phosphorylates GSK3, Rattus norvegicus"
xref: Reactome:REACT_12430 "AKT phosphorylates FOXO1A, Homo sapiens"
xref: Reactome:REACT_12437 "MSK1 activates ATF1, Homo sapiens"
xref: Reactome:REACT_12461 "AKT phosphorylates IKKalpha, Homo sapiens"
xref: Reactome:REACT_12485 "AKT can phosphorylate RSK, Homo sapiens"
xref: Reactome:REACT_12487 "ERK1/2/5 activate RSK1/2/3, Homo sapiens"
xref: Reactome:REACT_12518 "Activation of TAK1-TAB2 complex, Homo sapiens"
xref: Reactome:REACT_12532 "AKT phosphorylates TSC2, inhibiting it, Homo sapiens"
xref: Reactome:REACT_12537 "AKT phosphorylates MDM2, Homo sapiens"
xref: Reactome:REACT_12546 "p38MAPK phosphorylates MSK1, Homo sapiens"
xref: Reactome:REACT_12549 "AKT phosphorylates GSK3, Homo sapiens"
xref: Reactome:REACT_12557 "Phosphorylation of PKC theta, Homo sapiens"
xref: Reactome:REACT_12565 "AKT phosphorylates BAD, Homo sapiens"
xref: Reactome:REACT_12572 "AKT can phosphorylate forkhead box transcription factors, Homo sapiens"
xref: Reactome:REACT_12573 "Phosphorylation of CARMA1, Homo sapiens"
xref: Reactome:REACT_12576 "ERK1/2 phosphorylates MSK1, Homo sapiens"
xref: Reactome:REACT_12581 "Activation of IKK complex, Homo sapiens"
xref: Reactome:REACT_12584 "PDK1 phosphorylates AKT at T308, Homo sapiens"
xref: Reactome:REACT_12586 "MAPKAPK2 phosphorylates CREB at Serine 133, Homo sapiens"
xref: Reactome:REACT_12597 "AKT phosphorylates CREB, Homo sapiens"
xref: Reactome:REACT_12614 "AKT can phosphorylate NUR77, Homo sapiens"
xref: Reactome:REACT_12619 "Phosphorylation of Bcl10, Homo sapiens"
xref: Reactome:REACT_12622 "RSK1/2/3 phosphorylates CREB at Serine 133, Homo sapiens"
xref: Reactome:REACT_12625 "ERK5 activates the transcription factor MEF2, Rattus norvegicus"
xref: Reactome:REACT_12631 "MSK1 activates CREB, Homo sapiens"
xref: Reactome:REACT_13421 "Irak is activated, Rattus norvegicus"
xref: Reactome:REACT_13502 "IKKbeta phosphorylates IkB causing NF-kB to dissociate, Homo sapiens"
xref: Reactome:REACT_136 "MEK1 phosphorylates ERK-1, Homo sapiens"
xref: Reactome:REACT_13726 "IKKbeta is activated, Homo sapiens"
xref: Reactome:REACT_13775 "IRAK is activated, Homo sapiens"
xref: Reactome:REACT_1469 "perilipin + 3 ATP -> phosphorylated perilipin + 3 ADP, Rattus norvegicus"
xref: Reactome:REACT_15377 "PKA phosphorylates CREB, Homo sapiens"
xref: Reactome:REACT_1621 "perilipin + 3 ATP -> phosphorylated perilipin + 3 ADP, Mus musculus"
xref: Reactome:REACT_1734 "perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP, Homo sapiens"
xref: Reactome:REACT_18263 "Phosphorylation of MARCKS by Protein kinase C, alpha type, Homo sapiens"
xref: Reactome:REACT_18275 "Phosphorylation of eIF2-alpha by PERK, Homo sapiens"
xref: Reactome:REACT_18293 "Phosphorylation of FANCD2 by ATR/ATM, Homo sapiens"
xref: Reactome:REACT_18335 "Phosphorylation of FANCI by ATM/ATR, Homo sapiens"
xref: Reactome:REACT_1836 "Inactivation of MEK1 by p34cdc2, Homo sapiens"
xref: Reactome:REACT_18399 "Autophosphorylation of IRE1 dimer, Homo sapiens"
xref: Reactome:REACT_19152 "CERT + ATP => monophospho-CERT + ADP, Homo sapiens"
xref: Reactome:REACT_19154 "Myosin regulatory light chain phosphorylation by Rock2, Gallus gallus"
xref: Reactome:REACT_19156 "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP, Homo sapiens"
xref: Reactome:REACT_19168 "Transphosphorylation of pLIMK1, Homo sapiens"
xref: Reactome:REACT_19191 "Myosin regulatory light chain phosphorylation by ROCK, Homo sapiens"
xref: Reactome:REACT_19197 "Autophosphorylation of PAK, Homo sapiens"
xref: Reactome:REACT_19221 "Phosphorylation of LIMK-1 by PAK, Homo sapiens"
xref: Reactome:REACT_19232 "AKT interacts and phosphorylates Cot, Homo sapiens"
xref: Reactome:REACT_19276 "Phosphorylation of cofilin by LIMK-1, Homo sapiens"
xref: Reactome:REACT_19282 "LIM kinase phosphorylation by ROCK, Homo sapiens"
xref: Reactome:REACT_19285 "Phosphorylation of CRMPs by Cdk5, Homo sapiens"
xref: Reactome:REACT_19311 "ROCK1 activates LIM kinase 2 (rat), Homo sapiens"
xref: Reactome:REACT_19321 "Phosphorylation of CRMPs by GSK3beta, Homo sapiens"
xref: Reactome:REACT_19361 "Phosphorylation of cofilin by LIMK-1, Mus musculus"
xref: Reactome:REACT_20541 "Phosphorylation of cPLA2 by MAPK p38 alpha, Homo sapiens"
xref: Reactome:REACT_21251 "c-FOS activation by phospho ERK1/2, Homo sapiens"
xref: Reactome:REACT_21276 "Phosphorylation of MEF2 proteins by p38, Homo sapiens"
xref: Reactome:REACT_21321 "Phosphorylation of E proteins by p38 MAPK, Homo sapiens"
xref: Reactome:REACT_21334 "Phosphorylation of E47 by p38 MAPK, Mus musculus"
xref: Reactome:REACT_21338 "activated human TAK1 phosphorylates MKK3/MKK6, Homo sapiens"
xref: Reactome:REACT_21367 "Activated TAK1 phosphorylates MKK4/MKK7, Homo sapiens"
xref: Reactome:REACT_21375 "Active p38 MAPK phosphorylates MAPKAPK2 or 3, Homo sapiens"
xref: Reactome:REACT_22101 "Phosphorylation of L1 by p90rsk, Homo sapiens"
xref: Reactome:REACT_22105 "ALOX5 is phosphorylated by MAPKAP2, Homo sapiens"
xref: Reactome:REACT_22125 "IRAK4 phosphorylates IRAK1, Homo sapiens"
xref: Reactome:REACT_22162 "IRAK4-activated IRAK1 autophosphorylates, Homo sapiens"
xref: Reactome:REACT_22240 "Phosphorylation of L1 by p90rsk, Homo sapiens"
xref: Reactome:REACT_22325 "IRAK1 and 4 can phosphorylate Pellino-1 and 2., Homo sapiens"
xref: Reactome:REACT_22371 "Interaction of PAK1 with Rac1-GTP, Homo sapiens"
xref: Reactome:REACT_2247 "MEK2 phosphorylates ERK-2, Homo sapiens"
xref: Reactome:REACT_23849 "PKA/PKG phosphorylate Rap1GAP2, Homo sapiens"
xref: Reactome:REACT_24004 "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding, Homo sapiens"
xref: Reactome:REACT_24917 "Phosphorylation of MKK4 by activated TAK1, Gallus gallus"
xref: Reactome:REACT_24948 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9, Homo sapiens"
xref: Reactome:REACT_24965 "Phosphorylation of KSRP by MAP kinase p38, Homo sapiens"
xref: Reactome:REACT_25002 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9, Homo sapiens"
xref: Reactome:REACT_25011 "IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9, Homo sapiens"
xref: Reactome:REACT_25016 "Phosphorylation of HuR by PKCalpha, Homo sapiens"
xref: Reactome:REACT_25040 "Activation of recruited TAK1, Gallus gallus"
xref: Reactome:REACT_25086 "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9, Homo sapiens"
xref: Reactome:REACT_25096 "activated MEK2 phosphorylates ERK2, Gallus gallus"
xref: Reactome:REACT_25097 "IRAK4 autophosphorylation in the complex with activated TLR:MyD88:Mal, Homo sapiens"
xref: Reactome:REACT_25125 "Phosphorylation of CRY and PER Proteins, Homo sapiens"
xref: Reactome:REACT_25161 "phosphorylation of IRAK2 by activated IRAK4, Gallus gallus"
xref: Reactome:REACT_25171 "Phosphorylation of Tristetraproline (TTP) by MK2, Homo sapiens"
xref: Reactome:REACT_25174 "Phosphorylation of IKKs complex by activated TAK1, Gallus gallus"
xref: Reactome:REACT_25184 "Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9, Homo sapiens"
xref: Reactome:REACT_25187 "Phosphorylation of KSRP by Protein Kinase B/Akt, Homo sapiens"
xref: Reactome:REACT_25189 "chicken RIP1 facilitates IKKs complex activation, Gallus gallus"
xref: Reactome:REACT_25202 "Phosphorylation of HuR by PKCdelta, Homo sapiens"
xref: Reactome:REACT_25204 "activated IKKs phosphorylates IkB alpha causing the NFkB complex to dissociate from the phospho-IkB, Gallus gallus"
xref: Reactome:REACT_25231 "Phosphorylation of IRF3 by IKK epsilon(IKBKE) complexed with activated TLR3., Gallus gallus"
xref: Reactome:REACT_25285 "Phosphorylation of BRF1 by MK2, Homo sapiens"
xref: Reactome:REACT_25288 "Activation of TAK1 complex bound to activated TLR4:TRAM:TRIF:pUb-TRAF6, Homo sapiens"
xref: Reactome:REACT_25307 "Activation of recruited TAK1 within the complex p-IRAK2: pUb-TRAF6:TAB2/TAB3:TAB1:TAK1, Gallus gallus"
xref: Reactome:REACT_25326 "Phosphorylation of Khsrp by p38 (mouse), Mus musculus"
xref: Reactome:REACT_25335 "Phosphorylation of BRF1 by Protein Kinase B/Akt, Homo sapiens"
xref: Reactome:REACT_25346 "Phosphorylation of IRF3 by TBK1 complexed with activated TLR3, Gallus gallus"
xref: Reactome:REACT_25356 "Phosphorylation of Cry and Per Proteins, Mus musculus"
xref: Reactome:REACT_25369 "Phosphorylation of STAT1 at Ser727, Homo sapiens"
xref: Reactome:REACT_25375 "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3, Homo sapiens"
xref: Reactome:REACT_25376 "Phosphorylation of MKK3/MKK6 by activated TAK1, Gallus gallus"
xref: Reactome:REACT_25384 "Activation of JNK by DSCAM, Homo sapiens"
xref: Reactome:REACT_25394 "Autophosphorylation of chicken IRAK4, Gallus gallus"
xref: Reactome:REACT_27158 "IRAK4 binds to activated TLR5 or 15., Gallus gallus"
xref: Reactome:REACT_27180 "IRAK4 autophosphorylation within the complex activated TLR:MyD88, Homo sapiens"
xref: Reactome:REACT_27211 "Activation of recruited TAK1 within the complex p-IRAK2: pUb-TRAF6:TAB2/TAB3:TAB1:TAK1 upon TLR7 or 21 stimulation, Gallus gallus"
xref: Reactome:REACT_27238 "IRAK2 phosphorylation bound to the activated TLR7 (or TLR21) complex, Gallus gallus"
xref: Reactome:REACT_27261 "Autophosphorylation of IRAK4 bound to the activated TLR7 or 21complex., Gallus gallus"
xref: Reactome:REACT_27299 "Activated IRAK4 bound to activated TLR : MyD88 complex phosphorylates IRAK2, Gallus gallus"
xref: Reactome:REACT_28085 "AKT phosphorylates caspase-9, Taeniopygia guttata"
xref: Reactome:REACT_28092 "Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex, Sus scrofa"
xref: Reactome:REACT_28112 "MSK1 activates CREB, Gallus gallus"
xref: Reactome:REACT_28138 "Activation of cytosolic AMPK by phosphorylation, Danio rerio"
xref: Reactome:REACT_28220 "perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP, Sus scrofa"
xref: Reactome:REACT_28367 "AKT phosphorylates caspase-9, Rattus norvegicus"
xref: Reactome:REACT_28572 "Activation of recruited TAK1 within the complex viral dsRNA:TLR3:TRIF:pUb-TRAF6:TAB1:Ub-TAB2:Ub-TAB3: TAK1, Rattus norvegicus"
xref: Reactome:REACT_28620 "hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP, Canis familiaris"
xref: Reactome:REACT_28729 "Activation of TAK1-TAB2 complex, Gallus gallus"
xref: Reactome:REACT_28738 "Active p38 MAPK phosphorylates MAPKAPK2 or 3, Drosophila melanogaster"
xref: Reactome:REACT_28805 "ERK1/2 activates ELK1, Danio rerio"
xref: Reactome:REACT_28809 "Active p38 MAPK phosphorylates MAPKAPK2 or 3, Sus scrofa"
xref: Reactome:REACT_28822 "MEK2 phosphorylates ERK-2, Mus musculus"
xref: Reactome:REACT_28827 "LIM kinase phosphorylation by ROCK, Canis familiaris"
xref: Reactome:REACT_28936 "Activation of NF-kB complex, Bos taurus"
xref: Reactome:REACT_29008 "Phosphorylation of FANCI by ATM/ATR, Oryza sativa"
xref: Reactome:REACT_29035 "IKKbeta phosphorylates IkB causing NF-kB to dissociate, Mus musculus"
xref: Reactome:REACT_29159 "RSK1/2/3 phosphorylates CREB at Serine 133, Canis familiaris"
xref: Reactome:REACT_29403 "Phosphorylation of cPLA2 by MAPK p38 alpha, Gallus gallus"
xref: Reactome:REACT_29503 "Phosphorylation of PKC theta, Caenorhabditis elegans"
xref: Reactome:REACT_29509 "AKT phosphorylates p21Cip1 and p27Kip1, Mus musculus"
xref: Reactome:REACT_29530 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9, Mus musculus"
xref: Reactome:REACT_29733 "Phosphorylation of FANCI by ATM/ATR, Taeniopygia guttata"
xref: Reactome:REACT_29781 "Phosphorylation of eIF2-alpha by PERK, Taeniopygia guttata"
xref: Reactome:REACT_29936 "Phosphorylation of CRY and PER Proteins, Danio rerio"
xref: Reactome:REACT_29959 "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP, Canis familiaris"
xref: Reactome:REACT_29999 "AKT interacts and phosphorylates Cot, Bos taurus"
xref: Reactome:REACT_30143 "Inactivation of MEK1 by p34cdc2, Bos taurus"
xref: Reactome:REACT_30149 "Activation of claspin, Rattus norvegicus"
xref: Reactome:REACT_30175 "Phosphorylation of FANCI by ATM/ATR, Sus scrofa"
xref: Reactome:REACT_30231 "AKT phosphorylates MDM2, Bos taurus"
xref: Reactome:REACT_30415 "Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex, Canis familiaris"
xref: Reactome:REACT_30432 "Autophosphorylation of IRE1 dimer, Drosophila melanogaster"
xref: Reactome:REACT_30441 "LIM kinase phosphorylation by ROCK, Taeniopygia guttata"
xref: Reactome:REACT_30475 "Activation of cytosolic AMPK by phosphorylation, Taeniopygia guttata"
xref: Reactome:REACT_30512 "ERK1/2/5 activate RSK1/2/3, Rattus norvegicus"
xref: Reactome:REACT_30534 "Phosphorylation of FANCD2 by ATR/ATM, Taeniopygia guttata"
xref: Reactome:REACT_30570 "Activation of recruited TAK1 within the complex viral dsRNA:TLR3:TRIF:pUb-TRAF6:TAB1:Ub-TAB2:Ub-TAB3: TAK1, Xenopus tropicalis"
xref: Reactome:REACT_30575 "MAP kinase activates MAPKAPK2, MAPKAPK3 and MSK1, Rattus norvegicus"
xref: Reactome:REACT_30766 "MEK1 phosphorylates ERK-1, Canis familiaris"
xref: Reactome:REACT_30848 "ERK1/2/5 activate RSK1/2/3, Sus scrofa"
xref: Reactome:REACT_31008 "Phosphorylation of FANCI by ATM/ATR, Canis familiaris"
xref: Reactome:REACT_31108 "MAPKAPK2 phosphorylates CREB at Serine 133, Xenopus tropicalis"
xref: Reactome:REACT_31283 "Activation of cytosolic AMPK by phosphorylation, Canis familiaris"
xref: Reactome:REACT_31328 "IKKbeta phosphorylates IkB causing NF-kB to dissociate, Bos taurus"
xref: Reactome:REACT_31357 "Inactivation of MEK1 by p34cdc2, Gallus gallus"
xref: Reactome:REACT_31513 "Activation of cytosolic AMPK by phosphorylation, Caenorhabditis elegans"
xref: Reactome:REACT_31523 "Phosphorylation of PKC theta, Mus musculus"
xref: Reactome:REACT_31662 "Phosphorylation of cPLA2 by MAPK p38 alpha, Canis familiaris"
xref: Reactome:REACT_31760 "AKT phosphorylates caspase-9, Xenopus tropicalis"
xref: Reactome:REACT_31783 "Phosphorylation of FANCI by ATM/ATR, Arabidopsis thaliana"
xref: Reactome:REACT_31812 "AKT phosphorylates PRAS40, Canis familiaris"
xref: Reactome:REACT_31857 "Phosphorylation of MARCKS by Protein kinase C, alpha type, Danio rerio"
xref: Reactome:REACT_31893 "IKKbeta is activated, Sus scrofa"
xref: Reactome:REACT_32225 "Phosphorylation of Bcl10, Taeniopygia guttata"
xref: Reactome:REACT_32250 "AKT phosphorylates caspase-9, Canis familiaris"
xref: Reactome:REACT_32384 "Activated TAK1 mediates phosphorylation of the IKK Complex, Bos taurus"
xref: Reactome:REACT_32525 "AKT phosphorylates p21Cip1 and p27Kip1, Bos taurus"
xref: Reactome:REACT_32572 "Activated TAK1 mediates phosphorylation of the IKK Complex, Rattus norvegicus"
xref: Reactome:REACT_32621 "TORC2 (mTOR) phosphorylates AKT at S473, Bos taurus"
xref: Reactome:REACT_32932 "Recruitment and activation of Chk1, Taeniopygia guttata"
xref: Reactome:REACT_32954 "Phosphorylation of eIF2-alpha by PERK, Drosophila melanogaster"
xref: Reactome:REACT_32974 "AKT phosphorylates IKKalpha, Taeniopygia guttata"
xref: Reactome:REACT_33231 "Phosphorylation of cPLA2 by MAPK p38 alpha, Rattus norvegicus"
xref: Reactome:REACT_33306 "p38MAPK phosphorylates MSK1, Rattus norvegicus"
xref: Reactome:REACT_33413 "IKKbeta is activated, Danio rerio"
xref: Reactome:REACT_33562 "Phosphorylation of L1 by p90rsk, Taeniopygia guttata"
xref: Reactome:REACT_33594 "MAP kinase activates MAPKAPK2, MAPKAPK3 and MSK1, Taeniopygia guttata"
xref: Reactome:REACT_33640 "Phosphorylation of CRY and PER Proteins, Canis familiaris"
xref: Reactome:REACT_33709 "Phosphorylation of eIF2-alpha by PERK, Rattus norvegicus"
xref: Reactome:REACT_33874 "Recruitment and activation of Chk1, Xenopus tropicalis"
xref: Reactome:REACT_33935 "perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP, Canis familiaris"
xref: Reactome:REACT_33943 "PDK1 phosphorylates AKT at T308, Taeniopygia guttata"
xref: Reactome:REACT_34025 "IKKbeta is activated, Rattus norvegicus"
xref: Reactome:REACT_34068 "AKT interacts and phosphorylates Cot, Canis familiaris"
xref: Reactome:REACT_34104 "RSK1/2/3 phosphorylates CREB at Serine 133, Sus scrofa"
xref: Reactome:REACT_34451 "Activation of cytosolic AMPK by phosphorylation, Sus scrofa"
xref: Reactome:REACT_34455 "MEK1 phosphorylates ERK-1, Rattus norvegicus"
xref: Reactome:REACT_34482 "MAPKAPK2 phosphorylates CREB at Serine 133, Danio rerio"
xref: Reactome:REACT_34576 "Phosphorylation of CRY and PER Proteins, Bos taurus"
xref: Reactome:REACT_34701 "AKT can phosphorylate RSK, Bos taurus"
xref: Reactome:REACT_34785 "IKKbeta phosphorylates IkB causing NF-kB to dissociate, Canis familiaris"
xref: Reactome:REACT_38602 "AKT phosphorylates IKKalpha, Mus musculus"
xref: Reactome:REACT_388 "hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP, Rattus norvegicus"
xref: Reactome:REACT_40374 "MSK1 activates ATF1, Gallus gallus"
xref: Reactome:REACT_51458 "Active p38 MAPK phosphorylates MAPKAPK2 or 3, Gallus gallus"
xref: Reactome:REACT_51558 "AKT can phosphorylate forkhead box transcription factors, Mus musculus"
xref: Reactome:REACT_53247 "Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9, Gallus gallus"
xref: Reactome:REACT_54933 "CERT + ATP => monophospho-CERT + ADP, Rattus norvegicus"
xref: Reactome:REACT_60400 "AKT phosphorylates GSK3, Bos taurus"
xref: Reactome:REACT_6197 "Activated DAkt1 phosphorylates TSC2 which inhibits the TSC1/2 complex, Drosophila melanogaster"
xref: Reactome:REACT_6263 "DAkt1-mediated phosphorylation inactivates DFOXO, Drosophila melanogaster"
xref: Reactome:REACT_62985 "Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex, Mus musculus"
xref: Reactome:REACT_6719 "Phosphorylated MAPKs phosphorylate ATF-2, Homo sapiens"
xref: Reactome:REACT_6728 "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR4 complex, Homo sapiens"
xref: Reactome:REACT_6730 "Activation of recruited TAK1 within the complex viral dsRNA:TLR3:TRIF:pUb-TRAF6:TAB1:Ub-TAB2:Ub-TAB3: TAK1, Homo sapiens"
xref: Reactome:REACT_6750 "Activation of claspin, Homo sapiens"
xref: Reactome:REACT_6794 "Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal, Homo sapiens"
xref: Reactome:REACT_6833 "First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal, Homo sapiens"
xref: Reactome:REACT_6848 "Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex, Homo sapiens"
xref: Reactome:REACT_6869 "Recruitment and activation of Chk1, Homo sapiens"
xref: Reactome:REACT_69155 "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding, Canis familiaris"
xref: Reactome:REACT_6935 "Activated TAK1 mediates phosphorylation of the IKK Complex, Homo sapiens"
xref: Reactome:REACT_75759 "Atr Phosphorylates Histone H2A.X at Unsynapsed Regions, Mus musculus"
xref: Reactome:REACT_75904 "ATR Phosphorylates Histone H2A.X at Unsynapsed Regions, Homo sapiens"
xref: Reactome:REACT_75910 "SMG1 Phosphorylates UPF1 (Enhanced by Exon Junction Complex), Homo sapiens"
xref: Reactome:REACT_77037 "LIM kinase phosphorylation by ROCK, Gallus gallus"
xref: Reactome:REACT_77098 "Phosphorylation of cPLA2 by MAPK p38 alpha, Xenopus tropicalis"
xref: Reactome:REACT_77159 "ALOX5 is phosphorylated by MAPKAP2, Danio rerio"
xref: Reactome:REACT_77220 "ERK1/2 activates ELK1, Rattus norvegicus"
xref: Reactome:REACT_77282 "AKT can phosphorylate NUR77, Xenopus tropicalis"
xref: Reactome:REACT_77423 "AKT phosphorylates TSC2, inhibiting it, Drosophila melanogaster"
xref: Reactome:REACT_77580 "Phosphorylation of MARCKS by Protein kinase C, alpha type, Sus scrofa"
xref: Reactome:REACT_77617 "AKT phosphorylates MDM2, Taeniopygia guttata"
xref: Reactome:REACT_77748 "Myosin regulatory light chain phosphorylation by ROCK, Bos taurus"
xref: Reactome:REACT_77752 "perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP, Danio rerio"
xref: Reactome:REACT_77909 "PKA phosphorylates CREB, Taeniopygia guttata"
xref: Reactome:REACT_77980 "AKT phosphorylates MDM2, Xenopus tropicalis"
xref: Reactome:REACT_78070 "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP, Drosophila melanogaster"
xref: Reactome:REACT_78202 "AKT phosphorylates BAD, Mus musculus"
xref: Reactome:REACT_78246 "Phosphorylation of CRMPs by GSK3beta, Canis familiaris"
xref: Reactome:REACT_78283 "MSK1 activates ATF1, Bos taurus"
xref: Reactome:REACT_78357 "Inactivation of MEK1 by p34cdc2, Rattus norvegicus"
xref: Reactome:REACT_78364 "Phosphorylation of LIMK-1 by PAK, Taeniopygia guttata"
xref: Reactome:REACT_78401 "MEK1 phosphorylates ERK-1, Danio rerio"
xref: Reactome:REACT_78606 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9, Canis familiaris"
xref: Reactome:REACT_78657 "hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP, Bos taurus"
xref: Reactome:REACT_78797 "Phosphorylation of PKC theta, Danio rerio"
xref: Reactome:REACT_78839 "MEK2 phosphorylates ERK-2, Bos taurus"
xref: Reactome:REACT_78999 "TORC2 (mTOR) phosphorylates AKT at S473, Mus musculus"
xref: Reactome:REACT_79009 "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9, Xenopus tropicalis"
xref: Reactome:REACT_79017 "IRAK is activated, Bos taurus"
xref: Reactome:REACT_79041 "Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9, Taeniopygia guttata"
xref: Reactome:REACT_79081 "Autophosphorylation of IRE1 dimer, Caenorhabditis elegans"
xref: Reactome:REACT_79082 "Phosphorylation of CRMPs by Cdk5, Danio rerio"
xref: Reactome:REACT_79223 "Activation of IKK complex, Canis familiaris"
xref: Reactome:REACT_79270 "MAP kinase activates MAPKAPK2, MAPKAPK3 and MSK1, Mus musculus"
xref: Reactome:REACT_79290 "MSK1 activates ATF1, Canis familiaris"
xref: Reactome:REACT_79294 "Autophosphorylation of PAK, Canis familiaris"
xref: Reactome:REACT_79368 "Phosphorylated MAPKs phosphorylate ATF-2, Xenopus tropicalis"
xref: Reactome:REACT_79396 "AKT phosphorylates CREB, Xenopus tropicalis"
xref: Reactome:REACT_79454 "AKT phosphorylates p21Cip1 and p27Kip1, Xenopus tropicalis"
xref: Reactome:REACT_79465 "Phosphorylation of cofilin by LIMK-1, Dictyostelium discoideum"
xref: Reactome:REACT_79487 "MEK1 phosphorylates ERK-1, Caenorhabditis elegans"
xref: Reactome:REACT_79578 "AKT can phosphorylate NUR77, Taeniopygia guttata"
xref: Reactome:REACT_79606 "Phosphorylation of FANCD2 by ATR/ATM, Bos taurus"
xref: Reactome:REACT_79732 "AKT phosphorylates p21Cip1 and p27Kip1, Canis familiaris"
xref: Reactome:REACT_79796 "p38MAPK phosphorylates MSK1, Bos taurus"
xref: Reactome:REACT_79838 "Activation of TAK1-TAB2 complex, Rattus norvegicus"
xref: Reactome:REACT_79875 "LIM kinase phosphorylation by ROCK, Xenopus tropicalis"
xref: Reactome:REACT_79905 "TORC2 (mTOR) phosphorylates AKT at S473, Drosophila melanogaster"
xref: Reactome:REACT_80036 "Phosphorylation of FANCI by ATM/ATR, Gallus gallus"
xref: Reactome:REACT_80060 "PKA phosphorylates CREB, Xenopus tropicalis"
xref: Reactome:REACT_80149 "Phosphorylation of FANCD2 by ATR/ATM, Caenorhabditis elegans"
xref: Reactome:REACT_80188 "p38MAPK phosphorylates MSK1, Sus scrofa"
xref: Reactome:REACT_80214 "AKT phosphorylates TSC2, inhibiting it, Canis familiaris"
xref: Reactome:REACT_80294 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9, Xenopus tropicalis"
xref: Reactome:REACT_80369 "Activation of NF-kB complex, Rattus norvegicus"
xref: Reactome:REACT_80488 "AKT phosphorylates p21Cip1 and p27Kip1, Taeniopygia guttata"
xref: Reactome:REACT_80566 "RSK1/2/3 phosphorylates CREB at Serine 133, Rattus norvegicus"
xref: Reactome:REACT_80571 "Activation of claspin, Mus musculus"
xref: Reactome:REACT_80638 "MSK1 activates ATF1, Rattus norvegicus"
xref: Reactome:REACT_80833 "Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9, Bos taurus"
xref: Reactome:REACT_80847 "perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP, Bos taurus"
xref: Reactome:REACT_80870 "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9, Bos taurus"
xref: Reactome:REACT_80884 "Inactivation of MEK1 by p34cdc2, Xenopus tropicalis"
xref: Reactome:REACT_80885 "Phosphorylation of CARMA1, Danio rerio"
xref: Reactome:REACT_80896 "Recruitment and activation of Chk1, Sus scrofa"
xref: Reactome:REACT_80942 "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9, Canis familiaris"
xref: Reactome:REACT_80981 "Autophosphorylation of PAK, Danio rerio"
xref: Reactome:REACT_80994 "ALOX5 is phosphorylated by MAPKAP2, Xenopus tropicalis"
xref: Reactome:REACT_81006 "Phosphorylated MAPKs phosphorylate ATF-2, Taeniopygia guttata"
xref: Reactome:REACT_81015 "Autophosphorylation of PAK, Mus musculus"
xref: Reactome:REACT_81028 "Activation of recruited TAK1 within the complex viral dsRNA:TLR3:TRIF:pUb-TRAF6:TAB1:Ub-TAB2:Ub-TAB3: TAK1, Mus musculus"
xref: Reactome:REACT_81170 "Phosphorylation of CARMA1, Bos taurus"
xref: Reactome:REACT_81226 "AKT phosphorylates BAD, Bos taurus"
xref: Reactome:REACT_81279 "Activation of TAK1-TAB2 complex, Mus musculus"
xref: Reactome:REACT_81426 "Autophosphorylation of IRE1 dimer, Schizosaccharomyces pombe"
xref: Reactome:REACT_81514 "perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP, Taeniopygia guttata"
xref: Reactome:REACT_81917 "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9, Gallus gallus"
xref: Reactome:REACT_81999 "CERT + ATP => monophospho-CERT + ADP, Mus musculus"
xref: Reactome:REACT_82094 "AKT can phosphorylate RSK, Canis familiaris"
xref: Reactome:REACT_82308 "AKT phosphorylates TSC2, inhibiting it, Taeniopygia guttata"
xref: Reactome:REACT_82341 "MEK2 phosphorylates ERK-2, Sus scrofa"
xref: Reactome:REACT_82426 "Phosphorylation of CRMPs by GSK3beta, Xenopus tropicalis"
xref: Reactome:REACT_82465 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9, Sus scrofa"
xref: Reactome:REACT_82486 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9, Danio rerio"
xref: Reactome:REACT_82487 "Transphosphorylation of pLIMK1, Gallus gallus"
xref: Reactome:REACT_82570 "Autophosphorylation of IRE1 dimer, Gallus gallus"
xref: Reactome:REACT_82577 "Phosphorylation of FANCD2 by ATR/ATM, Danio rerio"
xref: Reactome:REACT_82668 "AKT phosphorylates CREB, Taeniopygia guttata"
xref: Reactome:REACT_82929 "Phosphorylated MAPKs phosphorylate ATF-2, Canis familiaris"
xref: Reactome:REACT_82960 "Activation of IKK complex, Rattus norvegicus"
xref: Reactome:REACT_82976 "ALOX5 is phosphorylated by MAPKAP2, Canis familiaris"
xref: Reactome:REACT_82982 "PDK1 phosphorylates AKT at T308, Bos taurus"
xref: Reactome:REACT_83066 "ERK1/2/5 activate RSK1/2/3, Bos taurus"
xref: Reactome:REACT_83075 "Phosphorylation of CARMA1, Taeniopygia guttata"
xref: Reactome:REACT_83134 "IKKbeta phosphorylates IkB causing NF-kB to dissociate, Rattus norvegicus"
xref: Reactome:REACT_83280 "AKT can phosphorylate NUR77, Bos taurus"
xref: Reactome:REACT_83306 "RSK1/2/3 phosphorylates CREB at Serine 133, Gallus gallus"
xref: Reactome:REACT_83327 "Autophosphorylation of PAK, Sus scrofa"
xref: Reactome:REACT_83341 "Phosphorylation of cPLA2 by MAPK p38 alpha, Mus musculus"
xref: Reactome:REACT_83437 "AKT phosphorylates BAD, Rattus norvegicus"
xref: Reactome:REACT_83704 "Activation of recruited TAK1 within the complex viral dsRNA:TLR3:TRIF:pUb-TRAF6:TAB1:Ub-TAB2:Ub-TAB3: TAK1, Sus scrofa"
xref: Reactome:REACT_83820 "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding, Rattus norvegicus"
xref: Reactome:REACT_83896 "Phosphorylation of LIMK-1 by PAK, Canis familiaris"
xref: Reactome:REACT_83924 "Phosphorylation of CRMPs by Cdk5, Canis familiaris"
xref: Reactome:REACT_83927 "hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP, Sus scrofa"
xref: Reactome:REACT_84390 "Phosphorylation of LIMK-1 by PAK, Rattus norvegicus"
xref: Reactome:REACT_84454 "Phosphorylation of LIMK-1 by PAK, Gallus gallus"
xref: Reactome:REACT_84496 "Phosphorylation of Cdc25C at Ser 216 by Chk1, Sus scrofa"
xref: Reactome:REACT_84727 "Phosphorylation of Cdc25C at Ser 216 by Chk1, Xenopus tropicalis"
xref: Reactome:REACT_84803 "Phosphorylation of CRMPs by GSK3beta, Rattus norvegicus"
xref: Reactome:REACT_84957 "Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9, Xenopus tropicalis"
xref: Reactome:REACT_84970 "AKT phosphorylates IKKalpha, Drosophila melanogaster"
xref: Reactome:REACT_85026 "Inactivation of MEK1 by p34cdc2, Mus musculus"
xref: Reactome:REACT_85069 "Phosphorylation of CRMPs by Cdk5, Bos taurus"
xref: Reactome:REACT_85146 "MAP kinase activates MAPKAPK2, MAPKAPK3 and MSK1, Drosophila melanogaster"
xref: Reactome:REACT_85195 "IRAK is activated, Xenopus tropicalis"
xref: Reactome:REACT_85259 "ALOX5 is phosphorylated by MAPKAP2, Sus scrofa"
xref: Reactome:REACT_85327 "AKT phosphorylates CREB, Mus musculus"
xref: Reactome:REACT_85429 "MAPKAPK2 phosphorylates CREB at Serine 133, Gallus gallus"
xref: Reactome:REACT_85676 "Activation of NF-kB complex, Mus musculus"
xref: Reactome:REACT_85714 "IKKbeta phosphorylates IkB causing NF-kB to dissociate, Sus scrofa"
xref: Reactome:REACT_85726 "perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP, Xenopus tropicalis"
xref: Reactome:REACT_85756 "ERK1/2 phosphorylates MSK1, Bos taurus"
xref: Reactome:REACT_85863 "Phosphorylated MAPKs phosphorylate ATF-2, Danio rerio"
xref: Reactome:REACT_86006 "ERK5 activates the transcription factor MEF2, Oryza sativa"
xref: Reactome:REACT_86021 "Phosphorylation of FANCD2 by ATR/ATM, Drosophila melanogaster"
xref: Reactome:REACT_86110 "Activation of TAK1-TAB2 complex, Canis familiaris"
xref: Reactome:REACT_86121 "Phosphorylation of Bcl10, Danio rerio"
xref: Reactome:REACT_86147 "AKT phosphorylates CREB, Rattus norvegicus"
xref: Reactome:REACT_86151 "Activation of TAK1-TAB2 complex, Taeniopygia guttata"
xref: Reactome:REACT_86231 "TORC2 (mTOR) phosphorylates AKT at S473, Xenopus tropicalis"
xref: Reactome:REACT_86283 "PDK1 phosphorylates AKT at T308, Drosophila melanogaster"
xref: Reactome:REACT_86598 "PKA phosphorylates CREB, Sus scrofa"
xref: Reactome:REACT_86646 "Autophosphorylation of IRE1 dimer, Sus scrofa"
xref: Reactome:REACT_86677 "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP, Danio rerio"
xref: Reactome:REACT_86724 "AKT can phosphorylate forkhead box transcription factors, Bos taurus"
xref: Reactome:REACT_86739 "Recruitment and activation of Chk1, Rattus norvegicus"
xref: Reactome:REACT_86841 "AKT phosphorylates PRAS40, Mus musculus"
xref: Reactome:REACT_86847 "Phosphorylation of FANCI by ATM/ATR, Rattus norvegicus"
xref: Reactome:REACT_86929 "LIM kinase phosphorylation by ROCK, Rattus norvegicus"
xref: Reactome:REACT_86978 "Activated TAK1 mediates phosphorylation of the IKK Complex, Canis familiaris"
xref: Reactome:REACT_86988 "Phosphorylation of FANCD2 by ATR/ATM, Arabidopsis thaliana"
xref: Reactome:REACT_87026 "Phosphorylation of CRMPs by Cdk5, Mus musculus"
xref: Reactome:REACT_87041 "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9, Taeniopygia guttata"
xref: Reactome:REACT_87092 "Phosphorylation of CRY and PER Proteins, Rattus norvegicus"
xref: Reactome:REACT_87111 "ERK1/2 activates ELK1, Bos taurus"
xref: Reactome:REACT_87190 "Activation of IKK complex, Bos taurus"
xref: Reactome:REACT_87348 "Phosphorylation of PKC theta, Gallus gallus"
xref: Reactome:REACT_87421 "Phosphorylation of cofilin by LIMK-1, Drosophila melanogaster"
xref: Reactome:REACT_87451 "AKT interacts and phosphorylates Cot, Rattus norvegicus"
xref: Reactome:REACT_87456 "IRAK is activated, Mus musculus"
xref: Reactome:REACT_87461 "Autophosphorylation of PAK, Xenopus tropicalis"
xref: Reactome:REACT_87481 "Activation of cytosolic AMPK by phosphorylation, Mus musculus"
xref: Reactome:REACT_87543 "AKT phosphorylates CREB, Canis familiaris"
xref: Reactome:REACT_87575 "CERT + ATP => monophospho-CERT + ADP, Xenopus tropicalis"
xref: Reactome:REACT_87625 "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9, Sus scrofa"
xref: Reactome:REACT_87637 "perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP, Gallus gallus"
xref: Reactome:REACT_87667 "AKT interacts and phosphorylates Cot, Xenopus tropicalis"
xref: Reactome:REACT_87833 "PDK1 phosphorylates AKT at T308, Rattus norvegicus"
xref: Reactome:REACT_87846 "ERK1/2/5 activate RSK1/2/3, Saccharomyces cerevisiae"
xref: Reactome:REACT_87861 "Phosphorylation of PKC theta, Rattus norvegicus"
xref: Reactome:REACT_87870 "Phosphorylated MAPKs phosphorylate ATF-2, Schizosaccharomyces pombe"
xref: Reactome:REACT_87896 "ALOX5 is phosphorylated by MAPKAP2, Bos taurus"
xref: Reactome:REACT_88189 "MSK1 activates ATF1, Mus musculus"
xref: Reactome:REACT_88241 "AKT can phosphorylate forkhead box transcription factors, Rattus norvegicus"
xref: Reactome:REACT_88277 "Activation of cytosolic AMPK by phosphorylation, Xenopus tropicalis"
xref: Reactome:REACT_88488 "Phosphorylation of L1 by p90rsk, Bos taurus"
xref: Reactome:REACT_88490 "Myosin regulatory light chain phosphorylation by ROCK, Caenorhabditis elegans"
xref: Reactome:REACT_88529 "Activation of claspin, Gallus gallus"
xref: Reactome:REACT_88559 "Phosphorylation of FANCD2 by ATR/ATM, Xenopus tropicalis"
xref: Reactome:REACT_88591 "Activated TAK1 mediates phosphorylation of the IKK Complex, Danio rerio"
xref: Reactome:REACT_88650 "MSK1 activates ATF1, Taeniopygia guttata"
xref: Reactome:REACT_88937 "IKKbeta is activated, Mus musculus"
xref: Reactome:REACT_88973 "Phosphorylation of L1 by p90rsk, Mus musculus"
xref: Reactome:REACT_89047 "AKT phosphorylates MDM2, Rattus norvegicus"
xref: Reactome:REACT_89054 "RSK1/2/3 phosphorylates CREB at Serine 133, Xenopus tropicalis"
xref: Reactome:REACT_89078 "MSK1 activates CREB, Danio rerio"
xref: Reactome:REACT_89089 "Phosphorylation of L1 by p90rsk, Caenorhabditis elegans"
xref: Reactome:REACT_89170 "Phosphorylation of FANCI by ATM/ATR, Bos taurus"
xref: Reactome:REACT_89266 "hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP, Danio rerio"
xref: Reactome:REACT_89355 "Activation of claspin, Danio rerio"
xref: Reactome:REACT_89389 "Transphosphorylation of pLIMK1, Xenopus tropicalis"
xref: Reactome:REACT_89425 "AKT phosphorylates BAD, Canis familiaris"
xref: Reactome:REACT_89433 "Phosphorylated MAPKs phosphorylate ATF-2, Bos taurus"
xref: Reactome:REACT_89557 "RSK1/2/3 phosphorylates CREB at Serine 133, Taeniopygia guttata"
xref: Reactome:REACT_89611 "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9, Mus musculus"
xref: Reactome:REACT_89699 "IRAK is activated, Danio rerio"
xref: Reactome:REACT_89806 "hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP, Xenopus tropicalis"
xref: Reactome:REACT_89830 "Activation of TAK1-TAB2 complex, Danio rerio"
xref: Reactome:REACT_89908 "ERK5 activates the transcription factor MEF2, Bos taurus"
xref: Reactome:REACT_89984 "Phosphorylation of PKC theta, Sus scrofa"
xref: Reactome:REACT_90010 "Phosphorylation of eIF2-alpha by PERK, Canis familiaris"
xref: Reactome:REACT_90071 "Phosphorylation of eIF2-alpha by PERK, Gallus gallus"
xref: Reactome:REACT_90165 "Phosphorylation of PKC theta, Canis familiaris"
xref: Reactome:REACT_90173 "TORC2 (mTOR) phosphorylates AKT at S473, Rattus norvegicus"
xref: Reactome:REACT_90268 "p38MAPK phosphorylates MSK1, Taeniopygia guttata"
xref: Reactome:REACT_90319 "PDK1 phosphorylates AKT at T308, Mus musculus"
xref: Reactome:REACT_90333 "AKT phosphorylates GSK3, Canis familiaris"
xref: Reactome:REACT_90350 "Activation of NF-kB complex, Canis familiaris"
xref: Reactome:REACT_90442 "MAP kinase activates MAPKAPK2, MAPKAPK3 and MSK1, Canis familiaris"
xref: Reactome:REACT_90464 "Phosphorylation of LIMK-1 by PAK, Xenopus tropicalis"
xref: Reactome:REACT_90486 "AKT phosphorylates TSC2, inhibiting it, Rattus norvegicus"
xref: Reactome:REACT_90546 "Active p38 MAPK phosphorylates MAPKAPK2 or 3, Danio rerio"
xref: Reactome:REACT_90590 "MAPKAPK2 phosphorylates CREB at Serine 133, Mus musculus"
xref: Reactome:REACT_90752 "TORC2 (mTOR) phosphorylates AKT at S473, Caenorhabditis elegans"
xref: Reactome:REACT_91042 "Transphosphorylation of pLIMK1, Rattus norvegicus"
xref: Reactome:REACT_91083 "Phosphorylation of PKC theta, Bos taurus"
xref: Reactome:REACT_91184 "Recruitment and activation of Chk1, Danio rerio"
xref: Reactome:REACT_91247 "Phosphorylation of cofilin by LIMK-1, Xenopus tropicalis"
xref: Reactome:REACT_91489 "Autophosphorylation of IRE1 dimer, Taeniopygia guttata"
xref: Reactome:REACT_91679 "Activation of TAK1-TAB2 complex, Bos taurus"
xref: Reactome:REACT_91687 "Phosphorylation of FANCI by ATM/ATR, Xenopus tropicalis"
xref: Reactome:REACT_91695 "AKT phosphorylates GSK3, Taeniopygia guttata"
xref: Reactome:REACT_91715 "AKT phosphorylates GSK3, Mus musculus"
xref: Reactome:REACT_91808 "Autophosphorylation of IRE1 dimer, Mus musculus"
xref: Reactome:REACT_91830 "Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9, Sus scrofa"
xref: Reactome:REACT_92125 "Activation of IKK complex, Mus musculus"
xref: Reactome:REACT_92263 "TORC2 (mTOR) phosphorylates AKT at S473, Taeniopygia guttata"
xref: Reactome:REACT_92406 "Phosphorylation of CRMPs by Cdk5, Sus scrofa"
xref: Reactome:REACT_92416 "ERK1/2 phosphorylates MSK1, Caenorhabditis elegans"
xref: Reactome:REACT_92486 "AKT phosphorylates CREB, Bos taurus"
xref: Reactome:REACT_92872 "PKA phosphorylates CREB, Bos taurus"
xref: Reactome:REACT_92890 "ERK1/2/5 activate RSK1/2/3, Taeniopygia guttata"
xref: Reactome:REACT_92893 "ERK1/2 phosphorylates MSK1, Sus scrofa"
xref: Reactome:REACT_93044 "MSK1 activates CREB, Mus musculus"
xref: Reactome:REACT_93073 "Autophosphorylation of IRE1 dimer, Rattus norvegicus"
xref: Reactome:REACT_93082 "ERK5 activates the transcription factor MEF2, Danio rerio"
xref: Reactome:REACT_93212 "RSK1/2/3 phosphorylates CREB at Serine 133, Bos taurus"
xref: Reactome:REACT_93229 "Activation of recruited TAK1 within the complex viral dsRNA:TLR3:TRIF:pUb-TRAF6:TAB1:Ub-TAB2:Ub-TAB3: TAK1, Canis familiaris"
xref: Reactome:REACT_93303 "ERK1/2 phosphorylates MSK1, Taeniopygia guttata"
xref: Reactome:REACT_93390 "MAP kinase activates MAPKAPK2, MAPKAPK3 and MSK1, Gallus gallus"
xref: Reactome:REACT_93505 "Phosphorylation of L1 by p90rsk, Drosophila melanogaster"
xref: Reactome:REACT_93588 "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP, Taeniopygia guttata"
xref: Reactome:REACT_93911 "ERK5 activates the transcription factor MEF2, Canis familiaris"
xref: Reactome:REACT_93914 "LIM kinase phosphorylation by ROCK, Mus musculus"
xref: Reactome:REACT_93919 "Activation of recruited TAK1 within the complex viral dsRNA:TLR3:TRIF:pUb-TRAF6:TAB1:Ub-TAB2:Ub-TAB3: TAK1, Bos taurus"
xref: Reactome:REACT_93998 "AKT can phosphorylate RSK, Caenorhabditis elegans"
xref: Reactome:REACT_94044 "Phosphorylation of CARMA1, Canis familiaris"
xref: Reactome:REACT_94069 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9, Gallus gallus"
xref: Reactome:REACT_94072 "Phosphorylation of L1 by p90rsk, Rattus norvegicus"
xref: Reactome:REACT_94250 "AKT phosphorylates PRAS40, Bos taurus"
xref: Reactome:REACT_94366 "Phosphorylation of CRMPs by GSK3beta, Danio rerio"
xref: Reactome:REACT_94474 "Activation of recruited TAK1 within the complex viral dsRNA:TLR3:TRIF:pUb-TRAF6:TAB1:Ub-TAB2:Ub-TAB3: TAK1, Danio rerio"
xref: Reactome:REACT_94526 "AKT phosphorylates TSC2, inhibiting it, Bos taurus"
xref: Reactome:REACT_94639 "Autophosphorylation of IRE1 dimer, Bos taurus"
xref: Reactome:REACT_94736 "p38MAPK phosphorylates MSK1, Gallus gallus"
xref: Reactome:REACT_95091 "AKT phosphorylates MDM2, Mus musculus"
xref: Reactome:REACT_95131 "CERT + ATP => monophospho-CERT + ADP, Bos taurus"
xref: Reactome:REACT_95329 "Activation of claspin, Taeniopygia guttata"
xref: Reactome:REACT_95335 "Phosphorylation of Bcl10, Rattus norvegicus"
xref: Reactome:REACT_95356 "MEK2 phosphorylates ERK-2, Taeniopygia guttata"
xref: Reactome:REACT_95369 "AKT phosphorylates PRAS40, Xenopus tropicalis"
xref: Reactome:REACT_95525 "Transphosphorylation of pLIMK1, Canis familiaris"
xref: Reactome:REACT_95566 "Phosphorylation of eIF2-alpha by PERK, Mus musculus"
xref: Reactome:REACT_95602 "hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP, Mus musculus"
xref: Reactome:REACT_95622 "Activation of recruited TAK1 within the complex viral dsRNA:TLR3:TRIF:pUb-TRAF6:TAB1:Ub-TAB2:Ub-TAB3: TAK1, Taeniopygia guttata"
xref: Reactome:REACT_95641 "PDK1 phosphorylates AKT at T308, Xenopus tropicalis"
xref: Reactome:REACT_95651 "Transphosphorylation of pLIMK1, Danio rerio"
xref: Reactome:REACT_95762 "Phosphorylation of FANCD2 by ATR/ATM, Dictyostelium discoideum"
xref: Reactome:REACT_95795 "ERK1/2/5 activate RSK1/2/3, Drosophila melanogaster"
xref: Reactome:REACT_95850 "Phosphorylation of L1 by p90rsk, Xenopus tropicalis"
xref: Reactome:REACT_95931 "MAP kinase activates MAPKAPK2, MAPKAPK3 and MSK1, Bos taurus"
xref: Reactome:REACT_95935 "AKT phosphorylates TSC2, inhibiting it, Xenopus tropicalis"
xref: Reactome:REACT_95951 "AKT can phosphorylate forkhead box transcription factors, Taeniopygia guttata"
xref: Reactome:REACT_95952 "ERK5 activates the transcription factor MEF2, Mus musculus"
xref: Reactome:REACT_96092 "p38MAPK phosphorylates MSK1, Canis familiaris"
xref: Reactome:REACT_96204 "ERK1/2 phosphorylates MSK1, Rattus norvegicus"
xref: Reactome:REACT_96268 "Phosphorylation of FANCD2 by ATR/ATM, Mus musculus"
xref: Reactome:REACT_96340 "MEK2 phosphorylates ERK-2, Rattus norvegicus"
xref: Reactome:REACT_96427 "AKT can phosphorylate RSK, Drosophila melanogaster"
xref: Reactome:REACT_96505 "ERK1/2 phosphorylates MSK1, Gallus gallus"
xref: Reactome:REACT_96534 "Phosphorylation of CRY and PER Proteins, Taeniopygia guttata"
xref: Reactome:REACT_96546 "CERT + ATP => monophospho-CERT + ADP, Danio rerio"
xref: Reactome:REACT_96553 "IKKbeta phosphorylates IkB causing NF-kB to dissociate, Xenopus tropicalis"
xref: Reactome:REACT_96657 "MSK1 activates CREB, Canis familiaris"
xref: Reactome:REACT_96659 "Phosphorylation of CARMA1, Mus musculus"
xref: Reactome:REACT_96804 "Recruitment and activation of Chk1, Mus musculus"
xref: Reactome:REACT_96823 "AKT can phosphorylate NUR77, Rattus norvegicus"
xref: Reactome:REACT_96825 "IRAK is activated, Sus scrofa"
xref: Reactome:REACT_96850 "MAPKAPK2 phosphorylates CREB at Serine 133, Rattus norvegicus"
xref: Reactome:REACT_97199 "Phosphorylation of CRMPs by Cdk5, Rattus norvegicus"
xref: Reactome:REACT_97207 "AKT phosphorylates GSK3, Xenopus tropicalis"
xref: Reactome:REACT_97335 "ERK5 activates the transcription factor MEF2, Arabidopsis thaliana"
xref: Reactome:REACT_97343 "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding, Bos taurus"
xref: Reactome:REACT_97347 "ERK1/2/5 activate RSK1/2/3, Caenorhabditis elegans"
xref: Reactome:REACT_97394 "CERT + ATP => monophospho-CERT + ADP, Canis familiaris"
xref: Reactome:REACT_97476 "Phosphorylation of LIMK-1 by PAK, Mus musculus"
xref: Reactome:REACT_97497 "IKKbeta is activated, Xenopus tropicalis"
xref: Reactome:REACT_97544 "MSK1 activates CREB, Taeniopygia guttata"
xref: Reactome:REACT_97593 "Phosphorylation of Cdc25C at Ser 216 by Chk1, Drosophila melanogaster"
xref: Reactome:REACT_97635 "Phosphorylation of cPLA2 by MAPK p38 alpha, Bos taurus"
xref: Reactome:REACT_97792 "Phosphorylation of Bcl10, Mus musculus"
xref: Reactome:REACT_97842 "IKKbeta is activated, Gallus gallus"
xref: Reactome:REACT_97853 "AKT can phosphorylate RSK, Mus musculus"
xref: Reactome:REACT_98007 "ERK1/2 phosphorylates MSK1, Danio rerio"
xref: Reactome:REACT_98032 "Inactivation of MEK1 by p34cdc2, Canis familiaris"
xref: Reactome:REACT_98044 "Phosphorylation of FANCD2 by ATR/ATM, Canis familiaris"
xref: Reactome:REACT_98057 "ALOX5 is phosphorylated by MAPKAP2, Rattus norvegicus"
xref: Reactome:REACT_98110 "ERK1/2 phosphorylates MSK1, Drosophila melanogaster"
xref: Reactome:REACT_98114 "Autophosphorylation of PAK, Bos taurus"
xref: Reactome:REACT_98193 "MSK1 activates ATF1, Danio rerio"
xref: Reactome:REACT_98197 "RSK1/2/3 phosphorylates CREB at Serine 133, Danio rerio"
xref: Reactome:REACT_98215 "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9, Rattus norvegicus"
xref: Reactome:REACT_98244 "Activated TAK1 mediates phosphorylation of the IKK Complex, Mus musculus"
xref: Reactome:REACT_98255 "ERK1/2/5 activate RSK1/2/3, Mus musculus"
xref: Reactome:REACT_98315 "Activation of cytosolic AMPK by phosphorylation, Drosophila melanogaster"
xref: Reactome:REACT_98317 "Phosphorylation of Cdc25C at Ser 216 by Chk1, Bos taurus"
xref: Reactome:REACT_98318 "AKT interacts and phosphorylates Cot, Mus musculus"
xref: Reactome:REACT_98411 "Activation of IKK complex, Sus scrofa"
xref: Reactome:REACT_98629 "MEK2 phosphorylates ERK-2, Canis familiaris"
xref: Reactome:REACT_98897 "RSK1/2/3 phosphorylates CREB at Serine 133, Mus musculus"
xref: Reactome:REACT_98965 "Phosphorylation of L1 by p90rsk, Sus scrofa"
xref: Reactome:REACT_98966 "MSK1 activates CREB, Bos taurus"
xref: Reactome:REACT_99035 "Activation of NF-kB complex, Sus scrofa"
xref: Reactome:REACT_99196 "Phosphorylation of CRMPs by GSK3beta, Mus musculus"
xref: Reactome:REACT_99214 "Phosphorylation of PKC theta, Drosophila melanogaster"
xref: Reactome:REACT_99234 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9, Rattus norvegicus"
xref: Reactome:REACT_99270 "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding, Sus scrofa"
xref: Reactome:REACT_99324 "Phosphorylation of eIF2-alpha by PERK, Danio rerio"
xref: Reactome:REACT_99345 "AKT phosphorylates MDM2, Canis familiaris"
xref: Reactome:REACT_99388 "Phosphorylation of FANCD2 by ATR/ATM, Rattus norvegicus"
xref: Reactome:REACT_99466 "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP, Bos taurus"
xref: Reactome:REACT_99563 "MAP kinase activates MAPKAPK2, MAPKAPK3 and MSK1, Danio rerio"
xref: Reactome:REACT_99566 "IKKbeta is activated, Canis familiaris"
xref: Reactome:REACT_99606 "Phosphorylation of eIF2-alpha by PERK, Sus scrofa"
xref: Reactome:REACT_99613 "PKA phosphorylates CREB, Gallus gallus"
xref: Reactome:REACT_99631 "IRAK is activated, Gallus gallus"
xref: Reactome:REACT_99778 "MAPKAPK2 phosphorylates CREB at Serine 133, Canis familiaris"
xref: Reactome:REACT_99808 "MAP kinase activates MAPKAPK2, MAPKAPK3 and MSK1, Xenopus tropicalis"
xref: Reactome:REACT_99812 "ERK1/2 activates ELK1, Sus scrofa"
xref: Reactome:REACT_99873 "Activation of recruited TAK1 within the complex viral dsRNA:TLR3:TRIF:pUb-TRAF6:TAB1:Ub-TAB2:Ub-TAB3: TAK1, Gallus gallus"
xref: Reactome:REACT_99884 "Phosphorylation of Bcl10, Canis familiaris"
xref: Reactome:REACT_99943 "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9, Danio rerio"
is_a: GO:0004672 ! protein kinase activity

[Term]
id: GO:0004675
name: transmembrane receptor protein serine/threonine kinase activity
namespace: molecular_function
def: "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.30]
synonym: "activin receptor kinase activity" NARROW [EC:2.7.11.30]
synonym: "ATP:receptor-protein phosphotransferase activity" EXACT [EC:2.7.11.30]
synonym: "receptor protein serine/threonine kinase activity" EXACT [EC:2.7.11.30]
synonym: "receptor serine/threonine protein kinase activity" EXACT [EC:2.7.11.30]
synonym: "receptor type I serine/threonine protein kinase activity" NARROW [EC:2.7.11.30]
synonym: "receptor type II serine/threonine protein kinase activity" NARROW [EC:2.7.11.30]
synonym: "STK13" RELATED [EC:2.7.11.30]
synonym: "TGF-beta kinase activity" NARROW [EC:2.7.11.30]
xref: EC:2.7.11.-
xref: MetaCyc:2.7.11.30-RXN
xref: Reactome:REACT_100769 "STAT3 activation, Rattus norvegicus"
xref: Reactome:REACT_101947 "STAT3 activation, Canis familiaris"
xref: Reactome:REACT_102061 "Activated type I receptor phosphorylates R-Smad1/5/8 directly, Canis familiaris"
xref: Reactome:REACT_106768 "Activated type I receptor phosphorylates SMAD2/3 directly, Canis familiaris"
xref: Reactome:REACT_109837 "Activated type I receptor phosphorylates R-Smad1/5/8 directly, Danio rerio"
xref: Reactome:REACT_110934 "Activated type I receptor phosphorylates R-Smad1/5/8 directly, Sus scrofa"
xref: Reactome:REACT_110950 "STAT3 activation, Gallus gallus"
xref: Reactome:REACT_114102 "Activated type I receptor phosphorylates SMAD2/3 directly, Drosophila melanogaster"
xref: Reactome:REACT_12052 "Activated type I receptor phosphorylates R-Smad1/5/8 directly, Homo sapiens"
xref: Reactome:REACT_12057 "STAT3 activation, Homo sapiens"
xref: Reactome:REACT_30655 "Activated type I receptor phosphorylates SMAD2/3 directly, Mus musculus"
xref: Reactome:REACT_31200 "Activated type I receptor phosphorylates SMAD2/3 directly, Rattus norvegicus"
xref: Reactome:REACT_31836 "Activated type I receptor phosphorylates SMAD2/3 directly, Danio rerio"
xref: Reactome:REACT_31960 "Activated type I receptor phosphorylates SMAD2/3 directly, Xenopus tropicalis"
xref: Reactome:REACT_6879 "Activated type I receptor phosphorylates SMAD2/3 directly, Homo sapiens"
xref: Reactome:REACT_77790 "Activated type I receptor phosphorylates SMAD2/3 directly, Taeniopygia guttata"
xref: Reactome:REACT_79926 "Activated type I receptor phosphorylates R-Smad1/5/8 directly, Rattus norvegicus"
xref: Reactome:REACT_80118 "Activated type I receptor phosphorylates SMAD2/3 directly, Bos taurus"
xref: Reactome:REACT_80791 "Activated type I receptor phosphorylates SMAD2/3 directly, Gallus gallus"
xref: Reactome:REACT_81330 "STAT3 activation, Sus scrofa"
xref: Reactome:REACT_81763 "Activated type I receptor phosphorylates SMAD2/3 directly, Sus scrofa"
xref: Reactome:REACT_82346 "STAT3 activation, Mus musculus"
xref: Reactome:REACT_82998 "Activated type I receptor phosphorylates R-Smad1/5/8 directly, Taeniopygia guttata"
xref: Reactome:REACT_83743 "STAT3 activation, Xenopus tropicalis"
xref: Reactome:REACT_86682 "Activated type I receptor phosphorylates R-Smad1/5/8 directly, Mus musculus"
xref: Reactome:REACT_87280 "Activated type I receptor phosphorylates R-Smad1/5/8 directly, Drosophila melanogaster"
xref: Reactome:REACT_93571 "STAT3 activation, Bos taurus"
xref: Reactome:REACT_95370 "Activated type I receptor phosphorylates R-Smad1/5/8 directly, Xenopus tropicalis"
xref: Reactome:REACT_95390 "Activated type I receptor phosphorylates R-Smad1/5/8 directly, Bos taurus"
xref: Reactome:REACT_95539 "STAT3 activation, Danio rerio"
xref: Reactome:REACT_96480 "Activated type I receptor phosphorylates R-Smad1/5/8 directly, Gallus gallus"
is_a: GO:0004674 ! protein serine/threonine kinase activity
is_a: GO:0019199 ! transmembrane receptor protein kinase activity
relationship: part_of GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway

[Term]
id: GO:0004676
name: 3-phosphoinositide-dependent protein kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of a phosphatidylinositol-3-phosphate." [GOC:mah]
synonym: "PDK activity" RELATED [PMID:10075713]
synonym: "phosphatidylinositol-3-phosphate protein kinase activity" EXACT [GOC:curators]
xref: EC:2.7.11.-
xref: Reactome:REACT_102949 "PDK1 activates PKC zeta, Canis familiaris"
xref: Reactome:REACT_104130 "PDK1 activates PKC zeta, Drosophila melanogaster"
xref: Reactome:REACT_112574 "PDK1 activates PKC zeta, Schizosaccharomyces pombe"
xref: Reactome:REACT_112723 "PDK1 activates PKC zeta, Gallus gallus"
xref: Reactome:REACT_115114 "PDK1 activates PKC zeta, Saccharomyces cerevisiae"
xref: Reactome:REACT_20600 "PDK1 activates PKC zeta, Homo sapiens"
xref: Reactome:REACT_23903 "PDK1 activates PKC zeta, Rattus norvegicus"
xref: Reactome:REACT_6260 "Activation of DAkt1 by DPDK1, Drosophila melanogaster"
xref: Reactome:REACT_6283 "DPDK1 phosphorylates and activates DS6K, Drosophila melanogaster"
xref: Reactome:REACT_77626 "PDK1 activates PKC zeta, Xenopus tropicalis"
xref: Reactome:REACT_78021 "PDK1 activates PKC zeta, Mus musculus"
xref: Reactome:REACT_86810 "PDK1 activates PKC zeta, Taeniopygia guttata"
xref: Reactome:REACT_96235 "PDK1 activates PKC zeta, Bos taurus"
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0004677
name: DNA-dependent protein kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of DNA." [GOC:mah]
xref: EC:2.7.11.-
xref: Reactome:REACT_115966 "Autophosphorylation of DNA-PKcs, Gallus gallus"
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0004679
name: AMP-activated protein kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of AMP." [GOC:mah]
synonym: "5'-AMP-activated protein kinase activity" EXACT []
synonym: "AMPK activity" RELATED [GOC:mah]
synonym: "SNF1A/AMP-activated protein kinase activity" NARROW []
xref: EC:2.7.11.-
xref: Reactome:REACT_100101 "Phosphorylated AMPK phosphorylates TSC2, Danio rerio"
xref: Reactome:REACT_100513 "Phosphorylated AMPK phosphorylates TSC2, Xenopus tropicalis"
xref: Reactome:REACT_101641 "pAMPK inactivates ACC2 inhibiting malonyl-CoA synthesis, Arabidopsis thaliana"
xref: Reactome:REACT_102231 "Phosphorylated AMPK phosphorylates TSC2, Bos taurus"
xref: Reactome:REACT_104140 "pAMPK inactivates ACC2 inhibiting malonyl-CoA synthesis, Gallus gallus"
xref: Reactome:REACT_105858 "pAMPK inactivates ACC2 inhibiting malonyl-CoA synthesis, Saccharomyces cerevisiae"
xref: Reactome:REACT_107230 "Phosphorylation of ChREBP at Serine 568 by AMPK, Mus musculus"
xref: Reactome:REACT_107271 "pAMPK inactivates ACC2 inhibiting malonyl-CoA synthesis, Mus musculus"
xref: Reactome:REACT_107536 "Phosphorylated AMPK phosphorylates TSC2, Rattus norvegicus"
xref: Reactome:REACT_11110 "pAMPK inactivates ACC2 inhibiting malonyl-CoA synthesis, Homo sapiens"
xref: Reactome:REACT_113551 "Phosphorylation of ChREBP at Serine 568 by AMPK, Danio rerio"
xref: Reactome:REACT_114056 "pAMPK inactivates ACC2 inhibiting malonyl-CoA synthesis, Danio rerio"
xref: Reactome:REACT_115260 "pAMPK inactivates ACC2 inhibiting malonyl-CoA synthesis, Taeniopygia guttata"
xref: Reactome:REACT_115507 "Phosphorylation of ChREBP at Serine 568 by AMPK, Xenopus tropicalis"
xref: Reactome:REACT_1706 "Phosphorylation of rChREBP(Ser 568) by rAMPK, Rattus norvegicus"
xref: Reactome:REACT_21348 "Phosphorylated AMPK phosphorylates TSC2, Homo sapiens"
xref: Reactome:REACT_21413 "AMPK phosphorylates Raptor, Homo sapiens"
xref: Reactome:REACT_28253 "pAMPK inactivates ACC2 inhibiting malonyl-CoA synthesis, Oryza sativa"
xref: Reactome:REACT_31105 "Phosphorylation of ChREBP at Serine 568 by AMPK, Bos taurus"
xref: Reactome:REACT_31214 "pAMPK inactivates ACC2 inhibiting malonyl-CoA synthesis, Canis familiaris"
xref: Reactome:REACT_32411 "pAMPK inactivates ACC2 inhibiting malonyl-CoA synthesis, Drosophila melanogaster"
xref: Reactome:REACT_32709 "pAMPK inactivates ACC2 inhibiting malonyl-CoA synthesis, Dictyostelium discoideum"
xref: Reactome:REACT_33102 "Phosphorylation of ChREBP at Serine 568 by AMPK, Sus scrofa"
xref: Reactome:REACT_349 "Phosphorylation of ChREBP at Serine 568 by AMPK, Homo sapiens"
xref: Reactome:REACT_82669 "pAMPK inactivates ACC2 inhibiting malonyl-CoA synthesis, Rattus norvegicus"
xref: Reactome:REACT_85819 "Phosphorylation of ChREBP at Serine 568 by AMPK, Canis familiaris"
xref: Reactome:REACT_86300 "pAMPK inactivates ACC2 inhibiting malonyl-CoA synthesis, Xenopus tropicalis"
xref: Reactome:REACT_86799 "Phosphorylated AMPK phosphorylates TSC2, Sus scrofa"
xref: Reactome:REACT_89177 "Phosphorylation of ChREBP at Serine 568 by AMPK, Gallus gallus"
xref: Reactome:REACT_93047 "Phosphorylation of ChREBP at Serine 568 by AMPK, Taeniopygia guttata"
xref: Reactome:REACT_93827 "pAMPK inactivates ACC2 inhibiting malonyl-CoA synthesis, Schizosaccharomyces pombe"
xref: Reactome:REACT_95348 "pAMPK inactivates ACC2 inhibiting malonyl-CoA synthesis, Sus scrofa"
xref: Reactome:REACT_96631 "Phosphorylated AMPK phosphorylates TSC2, Taeniopygia guttata"
xref: Reactome:REACT_96928 "Phosphorylated AMPK phosphorylates TSC2, Gallus gallus"
xref: Reactome:REACT_97108 "Phosphorylated AMPK phosphorylates TSC2, Canis familiaris"
xref: Reactome:REACT_97911 "Phosphorylated AMPK phosphorylates TSC2, Drosophila melanogaster"
xref: Reactome:REACT_98167 "pAMPK inactivates ACC2 inhibiting malonyl-CoA synthesis, Bos taurus"
xref: Reactome:REACT_99741 "Phosphorylated AMPK phosphorylates TSC2, Mus musculus"
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0004680
name: obsolete casein kinase activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "casein kinase activity" EXACT []
xref: EC:2.7.11.-
is_obsolete: true
replaced_by: GO:0004674

[Term]
id: GO:0004681
name: obsolete casein kinase I activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "casein kinase I activity" EXACT []
xref: EC:2.7.11.-
is_obsolete: true
replaced_by: GO:0004674

[Term]
id: GO:0004682
name: obsolete protein kinase CK2 activity
namespace: molecular_function
alt_id: GO:0008604
def: "OBSOLETE. Catalysis of the reaction: casein + ATP = phosphocasein + ADP." [EC:2.7.11.1]
comment: This term was made obsolete because it represents a gene product.
synonym: "casein kinase II activity" RELATED []
synonym: "casein kinase II, catalytic activity" EXACT []
synonym: "protein kinase CK2 activity" EXACT []
synonym: "protein kinase CK2, intrinsic catalyst activity" EXACT []
is_obsolete: true
replaced_by: GO:0004674

[Term]
id: GO:0004683
name: calmodulin-dependent protein kinase activity
namespace: molecular_function
alt_id: GO:0004684
alt_id: GO:0004685
alt_id: GO:0004688
def: "Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin." [GOC:mah, PMID:11264466]
subset: gosubset_prok
synonym: "ATP:caldesmon O-phosphotransferase activity" NARROW [EC:2.7.11.17]
synonym: "ATP:protein phosphotransferase (Ca2+/calmodulin-dependent) activity" EXACT [EC:2.7.11.17]
synonym: "Ca2+/calmodulin-dependent microtubule-associated protein 2 kinase activity" NARROW [EC:2.7.11.17]
synonym: "Ca2+/calmodulin-dependent protein kinase 1 activity" NARROW [EC:2.7.11.17]
synonym: "Ca2+/calmodulin-dependent protein kinase activity" EXACT [EC:2.7.11.17]
synonym: "Ca2+/calmodulin-dependent protein kinase II activity" NARROW [EC:2.7.11.17]
synonym: "Ca2+/calmodulin-dependent protein kinase IV activity" NARROW [EC:2.7.11.17]
synonym: "Ca2+/calmodulin-dependent protein kinase kinase activity" NARROW [EC:2.7.11.17]
synonym: "Ca2+/calmodulin-dependent protein kinase kinase beta activity" NARROW [EC:2.7.11.17]
synonym: "Ca2+/CaM-dependent kinase activity" EXACT []
synonym: "calcium- and calmodulin-dependent protein kinase activity" EXACT []
synonym: "calcium/calmodulin-dependent protein kinase activity" EXACT [EC:2.7.11.17]
synonym: "calcium/calmodulin-dependent protein kinase type II activity" NARROW [EC:2.7.11.17]
synonym: "caldesmon kinase (phosphorylating) activity" NARROW [EC:2.7.11.17]
synonym: "calmodulin regulated protein kinase activity" EXACT []
synonym: "calmodulin-dependent kinase II activity" NARROW [EC:2.7.11.17]
synonym: "calmodulin-dependent protein kinase I activity" NARROW []
synonym: "CaM kinase activity" EXACT [EC:2.7.11.17]
synonym: "CaM kinase II activity" NARROW [EC:2.7.11.17]
synonym: "CAM PKII" RELATED [EC:2.7.11.17]
synonym: "CaM-regulated serine/threonine kinase activity" EXACT [EC:2.7.11.17]
synonym: "CaMKI" RELATED [EC:2.7.11.17]
synonym: "CaMKII" RELATED [EC:2.7.11.17]
synonym: "CaMKIV" RELATED [EC:2.7.11.17]
synonym: "CaMKKalpha" RELATED [EC:2.7.11.17]
synonym: "CaMKKbeta" RELATED [EC:2.7.11.17]
synonym: "microtubule-associated protein 2 kinase activity" RELATED [EC:2.7.11.17]
synonym: "multifunctional calcium- and calmodulin-regulated protein kinase activity" RELATED []
synonym: "multifunctional calcium/calmodulin regulated protein kinase activity" RELATED []
synonym: "STK20" RELATED [EC:2.7.11.17]
xref: EC:2.7.11.17
xref: MetaCyc:2.7.11.17-RXN
xref: Reactome:REACT_101066 "CaMK IV phosphorylates CREB, Taeniopygia guttata"
xref: Reactome:REACT_103401 "CaMK IV autophosphorylation, Canis familiaris"
xref: Reactome:REACT_104304 "CaMK IV phosphorylates CREB, Sus scrofa"
xref: Reactome:REACT_105264 "CaMK IV phosphorylates CREB, Bos taurus"
xref: Reactome:REACT_107835 "CaMK IV autophosphorylation, Danio rerio"
xref: Reactome:REACT_108282 "Trafficking of GluR1-containing AMPA receptors, Bos taurus"
xref: Reactome:REACT_109911 "CaMK IV phosphorylates CREB, Danio rerio"
xref: Reactome:REACT_112694 "CaMK IV autophosphorylation, Xenopus tropicalis"
xref: Reactome:REACT_113927 "CaMK IV phosphorylates CREB, Xenopus tropicalis"
xref: Reactome:REACT_114360 "CaMK IV autophosphorylation, Dictyostelium discoideum"
xref: Reactome:REACT_115632 "CaMK IV phosphorylates CREB, Rattus norvegicus"
xref: Reactome:REACT_15320 "CaMK IV autophosphorylation, Homo sapiens"
xref: Reactome:REACT_15427 "CaMK IV phosphorylates CREB, Homo sapiens"
xref: Reactome:REACT_18393 "Trafficking of GluR1-containing AMPA receptors, Homo sapiens"
xref: Reactome:REACT_20576 "Phosphorylation of CREB by CaMKII, Homo sapiens"
xref: Reactome:REACT_20634 "Activation of CaMKII, Homo sapiens"
xref: Reactome:REACT_20635 "Activation of CaMKK, Homo sapiens"
xref: Reactome:REACT_20666 "Phosphorylation of CREB by CaMKIV, Homo sapiens"
xref: Reactome:REACT_31805 "CaMK IV autophosphorylation, Rattus norvegicus"
xref: Reactome:REACT_79933 "CaMK IV autophosphorylation, Sus scrofa"
xref: Reactome:REACT_82305 "CaMK IV autophosphorylation, Bos taurus"
xref: Reactome:REACT_83541 "CaMK IV autophosphorylation, Mus musculus"
xref: Reactome:REACT_83746 "Trafficking of GluR1-containing AMPA receptors, Mus musculus"
xref: Reactome:REACT_87347 "CaMK IV autophosphorylation, Taeniopygia guttata"
xref: Reactome:REACT_87478 "CaMK IV phosphorylates CREB, Mus musculus"
xref: Reactome:REACT_88976 "CaMK IV phosphorylates CREB, Canis familiaris"
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0004686
name: elongation factor-2 kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + [elongation factor 2] = ADP + [elongation factor 2] phosphate." [EC:2.7.11.20, MetaCyc:2.7.11.20-RXN]
synonym: "ATP:elongation factor 2 phosphotransferase activity" EXACT [EC:2.7.11.20]
synonym: "Ca/CaM-kinase III activity" EXACT [EC:2.7.11.20]
synonym: "calmodulin-dependent protein kinase III activity" EXACT [EC:2.7.11.20]
synonym: "CaM kinase III activity" EXACT [EC:2.7.11.20]
synonym: "eEF-2 kinase activity" EXACT []
synonym: "eEF2 kinase activity" EXACT [EC:2.7.11.20]
synonym: "eEF2K" RELATED [EC:2.7.11.20]
synonym: "EF2K" RELATED [EC:2.7.11.20]
synonym: "elongation factor 2 kinase activity" EXACT [EC:2.7.11.20]
synonym: "eukaryotic elongation factor 2 kinase activity" EXACT [EC:2.7.11.20]
synonym: "STK19" RELATED [EC:2.7.11.20]
xref: EC:2.7.11.20
xref: MetaCyc:2.7.11.20-RXN
is_a: GO:0004683 ! calmodulin-dependent protein kinase activity

[Term]
id: GO:0004687
name: myosin light chain kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + myosin-light-chain = ADP + myosin-light-chain phosphate." [EC:2.7.11.18]
synonym: "ATP:myosin-light-chain O-phosphotransferase" BROAD [EC:2.7.11.18]
synonym: "ATP:myosin-light-chain O-phosphotransferase activity" EXACT [EC:2.7.11.18]
synonym: "calcium/calmodulin-dependent myosin light chain kinase activity" EXACT [EC:2.7.11.18]
synonym: "MLCK" RELATED [EC:2.7.11.18]
synonym: "MLCkase activity" EXACT [EC:2.7.11.18]
synonym: "myosin kinase activity" EXACT [EC:2.7.11.18]
synonym: "myosin light chain protein kinase activity" EXACT [EC:2.7.11.18]
synonym: "myosin light-chain kinase" BROAD [EC:2.7.11.18]
synonym: "myosin light-chain kinase (phosphorylating)" EXACT [EC:2.7.11.18]
synonym: "myosin light-chain kinase (phosphorylating) activity" EXACT [EC:2.7.11.18]
synonym: "myosin light-chain kinase activity" EXACT [EC:2.7.11.18]
synonym: "myosin-light-chain kinase activity" EXACT []
synonym: "smooth-muscle-myosin-light-chain kinase activity" NARROW [EC:2.7.11.18]
synonym: "STK18" RELATED [EC:2.7.11.18]
xref: EC:2.7.11.18
xref: MetaCyc:2.7.11.18-RXN
xref: Reactome:REACT_20597 "Phosphorylation of Smooth Muscle Myosin Light Chains, Homo sapiens"
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0004689
name: phosphorylase kinase activity
namespace: molecular_function
alt_id: GO:0008606
def: "Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a." [EC:2.7.11.19]
subset: gosubset_prok
synonym: "ATP:phosphorylase-b phosphotransferase activity" EXACT [EC:2.7.11.19]
synonym: "dephosphophosphorylase kinase activity" EXACT [EC:2.7.11.19]
synonym: "glycogen phosphorylase kinase activity" EXACT [EC:2.7.11.19]
synonym: "PHK" RELATED [EC:2.7.11.19]
synonym: "phosphorylase B kinase activity" EXACT [EC:2.7.11.19]
synonym: "phosphorylase kinase (phosphorylating) activity" EXACT [EC:2.7.11.19]
synonym: "phosphorylase kinase, intrinsic catalyst activity" EXACT []
synonym: "STK17" RELATED [EC:2.7.11.19]
xref: EC:2.7.11.19
xref: MetaCyc:2.7.11.19-RXN
xref: Reactome:REACT_100467 "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP, Canis familiaris"
xref: Reactome:REACT_102661 "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP, Rattus norvegicus"
xref: Reactome:REACT_103236 "glycogen phosphorylase (PYGB) dimer b + 2 ATP => glycogen phosphorylase (PYGB) dimer a + 2 ADP, Danio rerio"
xref: Reactome:REACT_104276 "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP, Sus scrofa"
xref: Reactome:REACT_104799 "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP, Danio rerio"
xref: Reactome:REACT_108979 "glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP, Rattus norvegicus"
xref: Reactome:REACT_109223 "glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP, Canis familiaris"
xref: Reactome:REACT_112850 "glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP, Danio rerio"
xref: Reactome:REACT_113997 "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP, Drosophila melanogaster"
xref: Reactome:REACT_114606 "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP, Xenopus tropicalis"
xref: Reactome:REACT_1623 "glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP, Homo sapiens"
xref: Reactome:REACT_21331 "glycogen phosphorylase (PYGB) dimer b + 2 ATP => glycogen phosphorylase (PYGB) dimer a + 2 ADP, Homo sapiens"
xref: Reactome:REACT_30712 "glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP, Taeniopygia guttata"
xref: Reactome:REACT_31055 "glycogen phosphorylase (PYGB) dimer b + 2 ATP => glycogen phosphorylase (PYGB) dimer a + 2 ADP, Bos taurus"
xref: Reactome:REACT_33764 "glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP, Mus musculus"
xref: Reactome:REACT_34777 "glycogen phosphorylase (PYGB) dimer b + 2 ATP => glycogen phosphorylase (PYGB) dimer a + 2 ADP, Taeniopygia guttata"
xref: Reactome:REACT_63827 "glycogen phosphorylase (PYGB) dimer b + 2 ATP => glycogen phosphorylase (PYGB) dimer a + 2 ADP, Gallus gallus"
xref: Reactome:REACT_78716 "glycogen phosphorylase (PYGB) dimer b + 2 ATP => glycogen phosphorylase (PYGB) dimer a + 2 ADP, Rattus norvegicus"
xref: Reactome:REACT_81113 "glycogen phosphorylase (PYGB) dimer b + 2 ATP => glycogen phosphorylase (PYGB) dimer a + 2 ADP, Canis familiaris"
xref: Reactome:REACT_81152 "glycogen phosphorylase (PYGB) dimer b + 2 ATP => glycogen phosphorylase (PYGB) dimer a + 2 ADP, Xenopus tropicalis"
xref: Reactome:REACT_848 "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP, Homo sapiens"
xref: Reactome:REACT_85940 "glycogen phosphorylase (PYGB) dimer b + 2 ATP => glycogen phosphorylase (PYGB) dimer a + 2 ADP, Mus musculus"
xref: Reactome:REACT_95094 "glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP, Bos taurus"
xref: Reactome:REACT_96179 "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP, Mus musculus"
xref: Reactome:REACT_97773 "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP, Bos taurus"
xref: Reactome:REACT_98773 "glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP, Xenopus tropicalis"
xref: Reactome:REACT_98923 "glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP, Sus scrofa"
is_a: GO:0004683 ! calmodulin-dependent protein kinase activity

[Term]
id: GO:0004690
name: cyclic nucleotide-dependent protein kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of a cyclic nucleotide." [GOC:mah]
xref: EC:2.7.11.-
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0004691
name: cAMP-dependent protein kinase activity
namespace: molecular_function
alt_id: GO:0008602
def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cAMP." [EC:2.7.11.11]
synonym: "3',5' cAMP-dependent protein kinase activity" EXACT []
synonym: "3',5'-cAMP-dependent protein kinase activity" EXACT []
synonym: "adenosine 3',5'-cyclophosphate-dependent protein kinase activity" EXACT []
synonym: "AMPK" RELATED [EC:2.7.11.11]
synonym: "ATP:protein phosphotransferase (cAMP-dependent) activity" EXACT [EC:2.7.11.11]
synonym: "cAMP-dependent protein kinase, intrinsic catalyst activity" EXACT []
synonym: "cyclic AMP-dependent protein kinase activity" EXACT []
synonym: "PKA" RELATED [EC:2.7.11.11]
synonym: "PKA C" RELATED [EC:2.7.11.11]
synonym: "protein kinase A activity" BROAD [EC:2.7.11.11]
synonym: "STK22" RELATED [EC:2.7.11.11]
xref: EC:2.7.11.11
xref: MetaCyc:2.7.11.11-RXN
xref: Reactome:REACT_102063 "PKA phosphorylates PDE4B, Mus musculus"
xref: Reactome:REACT_102147 "PKA phosphorylates DARPP-32 on Thr34, Canis familiaris"
xref: Reactome:REACT_105123 "Phosphorylation of PF2K-Pase by PKA catalytic subunit, Taeniopygia guttata"
xref: Reactome:REACT_106524 "PKA phosphorylates DARPP-32 on Thr34, Mus musculus"
xref: Reactome:REACT_106641 "PKA phosphorylates DARPP-32 on Thr34, Rattus norvegicus"
xref: Reactome:REACT_107015 "Phosphorylation of ChREBP at Thr(666) by PKA, Gallus gallus"
xref: Reactome:REACT_108468 "Phosphorylation of PF2K-Pase by PKA catalytic subunit, Schizosaccharomyces pombe"
xref: Reactome:REACT_108471 "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA), Sus scrofa"
xref: Reactome:REACT_109379 "Phosphorylation of PF2K-Pase by PKA catalytic subunit, Canis familiaris"
xref: Reactome:REACT_110878 "Phosphorylation of ChREBP at Thr(666) by PKA, Sus scrofa"
xref: Reactome:REACT_112372 "Phosphorylation of ChREBP at Thr(666) by PKA, Xenopus tropicalis"
xref: Reactome:REACT_112409 "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA), Xenopus tropicalis"
xref: Reactome:REACT_112611 "Phosphorylation of pChREBP (Thr 666) at Ser(196) by PKA, Xenopus tropicalis"
xref: Reactome:REACT_113680 "Phosphorylation of PF2K-Pase by PKA catalytic subunit, Gallus gallus"
xref: Reactome:REACT_114719 "PKA phosphorylates DARPP-32 on Thr34, Xenopus tropicalis"
xref: Reactome:REACT_114883 "PKA phosphorylates PDE4B, Plasmodium falciparum"
xref: Reactome:REACT_115177 "PKA phosphorylates PDE4B, Caenorhabditis elegans"
xref: Reactome:REACT_115301 "PKA phosphorylates PDE4B, Dictyostelium discoideum"
xref: Reactome:REACT_15519 "PKA phosphorylates PDE4B, Homo sapiens"
xref: Reactome:REACT_15529 "PKA phosphorylates DARPP-32 on Thr34, Homo sapiens"
xref: Reactome:REACT_1620 "Phosphorylation of mpChREBP (Thr 666) at Ser(196) by mPKA, Mus musculus"
xref: Reactome:REACT_1761 "Phosphorylation of rPF2K-Pase by rPKA, Rattus norvegicus"
xref: Reactome:REACT_2128 "Phosphorylation of PF2K-Pase by PKA catalytic subunit, Homo sapiens"
xref: Reactome:REACT_23840 "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA), Homo sapiens"
xref: Reactome:REACT_23999 "IL3RB is phosphorylated on Ser-585, Homo sapiens"
xref: Reactome:REACT_28818 "Phosphorylation of PF2K-Pase by PKA catalytic subunit, Xenopus tropicalis"
xref: Reactome:REACT_304 "Phosphorylation of ChREBP at Thr(666) by PKA, Homo sapiens"
xref: Reactome:REACT_32440 "PKA phosphorylates DARPP-32 on Thr34, Sus scrofa"
xref: Reactome:REACT_33420 "Phosphorylation of pChREBP (Thr 666) at Ser(196) by PKA, Canis familiaris"
xref: Reactome:REACT_483 "Phosphorylation of pChREBP (Thr 666) at Ser(196) by PKA, Homo sapiens"
xref: Reactome:REACT_523 "Phosphorylation of mChREBP at Thr (666) residue by mPKA, Mus musculus"
xref: Reactome:REACT_77745 "Phosphorylation of ChREBP at Thr(666) by PKA, Bos taurus"
xref: Reactome:REACT_77754 "Phosphorylation of pChREBP (Thr 666) at Ser(196) by PKA, Gallus gallus"
xref: Reactome:REACT_79168 "PKA phosphorylates DARPP-32 on Thr34, Bos taurus"
xref: Reactome:REACT_79281 "PKA phosphorylates DARPP-32 on Thr34, Danio rerio"
xref: Reactome:REACT_79968 "Phosphorylation of ChREBP at Thr(666) by PKA, Taeniopygia guttata"
xref: Reactome:REACT_80822 "PKA phosphorylates PDE4B, Rattus norvegicus"
xref: Reactome:REACT_82788 "Phosphorylation of pChREBP (Thr 666) at Ser(196) by PKA, Danio rerio"
xref: Reactome:REACT_86025 "PKA phosphorylates PDE4B, Xenopus tropicalis"
xref: Reactome:REACT_86837 "Phosphorylation of PF2K-Pase by PKA catalytic subunit, Dictyostelium discoideum"
xref: Reactome:REACT_86948 "Phosphorylation of PF2K-Pase by PKA catalytic subunit, Sus scrofa"
xref: Reactome:REACT_87068 "PKA phosphorylates PDE4B, Bos taurus"
xref: Reactome:REACT_87322 "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA), Taeniopygia guttata"
xref: Reactome:REACT_88087 "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA), Saccharomyces cerevisiae"
xref: Reactome:REACT_88176 "PKA phosphorylates PDE4B, Danio rerio"
xref: Reactome:REACT_88555 "Phosphorylation of ChREBP at Thr(666) by PKA, Danio rerio"
xref: Reactome:REACT_88759 "Phosphorylation of pChREBP (Thr 666) at Ser(196) by PKA, Taeniopygia guttata"
xref: Reactome:REACT_89633 "PKA phosphorylates PDE4B, Canis familiaris"
xref: Reactome:REACT_90568 "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA), Gallus gallus"
xref: Reactome:REACT_92518 "Phosphorylation of pChREBP (Thr 666) at Ser(196) by PKA, Sus scrofa"
xref: Reactome:REACT_93136 "Phosphorylation of PF2K-Pase by PKA catalytic subunit, Bos taurus"
xref: Reactome:REACT_93846 "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA), Bos taurus"
xref: Reactome:REACT_94203 "Phosphorylation of PF2K-Pase by PKA catalytic subunit, Saccharomyces cerevisiae"
xref: Reactome:REACT_94372 "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA), Rattus norvegicus"
xref: Reactome:REACT_95670 "Phosphorylation of pChREBP (Thr 666) at Ser(196) by PKA, Bos taurus"
xref: Reactome:REACT_96593 "Phosphorylation of PF2K-Pase by PKA catalytic subunit, Mus musculus"
xref: Reactome:REACT_97814 "Phosphorylation of ChREBP at Thr(666) by PKA, Canis familiaris"
xref: Reactome:REACT_97831 "Phosphorylation of PF2K-Pase by PKA catalytic subunit, Danio rerio"
xref: Reactome:REACT_98768 "PKA phosphorylates PDE4B, Sus scrofa"
xref: Reactome:REACT_99116 "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA), Mus musculus"
is_a: GO:0004690 ! cyclic nucleotide-dependent protein kinase activity

[Term]
id: GO:0004692
name: cGMP-dependent protein kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cGMP." [GOC:mah]
synonym: "3':5'-cyclic GMP-dependent protein kinase activity" EXACT [EC:2.7.11.12]
synonym: "ATP:protein phosphotransferase (cGMP-dependent) activity" EXACT [EC:2.7.11.12]
synonym: "cGMP-dependent protein kinase ibeta activity" EXACT [EC:2.7.11.12]
synonym: "guanosine 3':5'-cyclic monophosphate-dependent protein kinase activity" EXACT [EC:2.7.11.12]
synonym: "PKG" RELATED [EC:2.7.11.12]
synonym: "PKG 1alpha" RELATED [EC:2.7.11.12]
synonym: "PKG 1beta" RELATED [EC:2.7.11.12]
synonym: "PKG II" RELATED [EC:2.7.11.12]
synonym: "STK23" RELATED [EC:2.7.11.12]
xref: EC:2.7.11.12
xref: MetaCyc:2.7.11.12-RXN
xref: Reactome:REACT_102275 "PKG1 phosphorylates BK channels, Danio rerio"
xref: Reactome:REACT_104065 "PKG1 phosphorylates BK channels, Mus musculus"
xref: Reactome:REACT_105153 "PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release, Gallus gallus"
xref: Reactome:REACT_105220 "PKG1 phosphorylates BK channels, Sus scrofa"
xref: Reactome:REACT_105914 "PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release, Rattus norvegicus"
xref: Reactome:REACT_107110 "PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release, Mus musculus"
xref: Reactome:REACT_110348 "PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release, Danio rerio"
xref: Reactome:REACT_111129 "Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II, Homo sapiens"
xref: Reactome:REACT_111245 "PTPS is phosphorylated by cGMP-dependant protein kinase II, Homo sapiens"
xref: Reactome:REACT_114536 "PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release, Xenopus tropicalis"
xref: Reactome:REACT_23982 "PKG1a phosphorylates BK channels, Bos taurus"
xref: Reactome:REACT_23991 "PKG1 phosphorylates BK channels, Homo sapiens"
xref: Reactome:REACT_24000 "PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release, Homo sapiens"
xref: Reactome:REACT_28275 "PKG1 phosphorylates BK channels, Taeniopygia guttata"
xref: Reactome:REACT_31633 "PKG1 phosphorylates BK channels, Gallus gallus"
xref: Reactome:REACT_77173 "PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release, Bos taurus"
xref: Reactome:REACT_90875 "PKG1 phosphorylates BK channels, Xenopus tropicalis"
xref: Reactome:REACT_93026 "PKG1 phosphorylates BK channels, Canis familiaris"
xref: Reactome:REACT_93738 "PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release, Taeniopygia guttata"
xref: Reactome:REACT_96033 "PKG1 phosphorylates BK channels, Rattus norvegicus"
xref: Reactome:REACT_98805 "PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release, Canis familiaris"
is_a: GO:0004690 ! cyclic nucleotide-dependent protein kinase activity

[Term]
id: GO:0004693
name: cyclin-dependent protein serine/threonine kinase activity
namespace: molecular_function
alt_id: GO:0016537
def: "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK)." [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670]
synonym: "ATP:cyclin phosphotransferase activity" EXACT [EC:2.7.11.22]
synonym: "cdc2 kinase activity" NARROW [EC:2.7.11.22]
synonym: "CDK" RELATED [EC:2.7.11.22]
synonym: "CDK activity" EXACT []
synonym: "CDK, catalytic subunit activity" EXACT []
synonym: "cdk-activating kinase activity" RELATED [EC:2.7.11.22]
synonym: "Cdk-activating protein kinase activity" EXACT [EC:2.7.11.22]
synonym: "cyclin D-cdk6 kinase activity" NARROW [EC:2.7.11.22]
synonym: "cyclin D-dependent kinase activity" NARROW [EC:2.7.11.22]
synonym: "cyclin E kinase activity" NARROW [EC:2.7.11.22]
synonym: "cyclin-A associated kinase activity" NARROW [EC:2.7.11.22]
synonym: "cyclin-dependent kinase 6 activity" NARROW [EC:2.7.11.22]
synonym: "cyclin-dependent kinase activity" BROAD [EC:2.7.11.22]
synonym: "cyclin-dependent kinase-2 activity" NARROW [EC:2.7.11.22]
synonym: "cyclin-dependent kinase-4 activity" NARROW [EC:2.7.11.22]
synonym: "cyclin-dependent protein kinase activity" BROAD []
synonym: "cyclin-dependent protein kinase, intrinsic catalyst activity" EXACT []
synonym: "D-type cyclin kinase activity" NARROW [EC:2.7.11.22]
synonym: "neuronal cdc2-like kinase activity" NARROW [EC:2.7.11.22]
xref: EC:2.7.11.22
xref: MetaCyc:2.7.11.22-RXN
xref: Reactome:REACT_100142 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Mus musculus"
xref: Reactome:REACT_100284 "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160), Xenopus tropicalis"
xref: Reactome:REACT_100368 "Phosphorylation of M phase proteins by active Cyclin B1:Cdc2 complexes, Mus musculus"
xref: Reactome:REACT_100867 "Phosphorylation of M phase proteins by active Cyclin B1:Cdc2 complexes, Canis familiaris"
xref: Reactome:REACT_101084 "Phosphorylation of M phase proteins by active Cyclin B1:Cdc2 complexes, Rattus norvegicus"
xref: Reactome:REACT_101412 "Cyclin D:Cdk4/6 mediated phosphorylation of Rb and dissociation of phospho-Rb from the E2F1/2/3:DP-1 complexes, Rattus norvegicus"
xref: Reactome:REACT_101652 "Cyclin B/Cdk1 mediate phosphorylation of NuMA, Mus musculus"
xref: Reactome:REACT_102726 "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160), Rattus norvegicus"
xref: Reactome:REACT_102799 "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2, Bos taurus"
xref: Reactome:REACT_103183 "Cyclin D:Cdk4/6 mediated phosphorylation of Rb and dissociation of phospho-Rb from the E2F1/2/3:DP-1 complexes, Sus scrofa"
xref: Reactome:REACT_103312 "Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21, Xenopus tropicalis"
xref: Reactome:REACT_103830 "Cyclin B/Cdk1 mediate phosphorylation of NuMA, Bos taurus"
xref: Reactome:REACT_104343 "Phosphorylation of M phase proteins by active Cyclin B1:Cdc2 complexes, Danio rerio"
xref: Reactome:REACT_104830 "Cyclin D:Cdk4/6 mediated phosphorylation of Rb and dissociation of phospho-Rb from the E2F1/2/3:DP-1 complexes, Canis familiaris"
xref: Reactome:REACT_106008 "Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21, Rattus norvegicus"
xref: Reactome:REACT_106596 "Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21, Canis familiaris"
xref: Reactome:REACT_107107 "Cyclin E:Cdk2-mediated phosphorylation of Rb, Danio rerio"
xref: Reactome:REACT_107135 "CDK5 phosphorylates DARPP-32 on Thr75, Rattus norvegicus"
xref: Reactome:REACT_107346 "Cyclin A:Cdk2 mediated phosphorylation of p27/p21, Rattus norvegicus"
xref: Reactome:REACT_107592 "Cyclin A:Cdk2 mediated phosphorylation of p27/p21, Danio rerio"
xref: Reactome:REACT_108100 "Cyclin A:Cdk2 mediated phosphorylation of p27/p21, Sus scrofa"
xref: Reactome:REACT_109124 "Cyclin B/Cdk1 mediate phosphorylation of NuMA, Rattus norvegicus"
xref: Reactome:REACT_109419 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Drosophila melanogaster"
xref: Reactome:REACT_109597 "CDK5 phosphorylates DARPP-32 on Thr75, Canis familiaris"
xref: Reactome:REACT_110505 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Mus musculus"
xref: Reactome:REACT_110542 "Cyclin D:Cdk4/6 mediated phosphorylation of Rb and dissociation of phospho-Rb from the E2F1/2/3:DP-1 complexes, Danio rerio"
xref: Reactome:REACT_111206 "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex, Homo sapiens"
xref: Reactome:REACT_111248 "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex, Homo sapiens"
xref: Reactome:REACT_112082 "Cyclin D:Cdk4/6 mediated phosphorylation of Rb and dissociation of phospho-Rb from the E2F1/2/3:DP-1 complexes, Xenopus tropicalis"
xref: Reactome:REACT_112868 "Cyclin B/Cdk1 mediate phosphorylation of NuMA, Xenopus tropicalis"
xref: Reactome:REACT_113042 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Saccharomyces cerevisiae"
xref: Reactome:REACT_113645 "Cyclin E:Cdk2-mediated phosphorylation of Rb, Xenopus tropicalis"
xref: Reactome:REACT_113808 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Schizosaccharomyces pombe"
xref: Reactome:REACT_113866 "Phosphorylation of M phase proteins by active Cyclin B1:Cdc2 complexes, Schizosaccharomyces pombe"
xref: Reactome:REACT_115193 "CDK5 phosphorylates DARPP-32 on Thr75, Xenopus tropicalis"
xref: Reactome:REACT_115457 "Phosphorylation of M phase proteins by active Cyclin B1:Cdc2 complexes, Saccharomyces cerevisiae"
xref: Reactome:REACT_15365 "CDK5 phosphorylates DARPP-32 on Thr75, Homo sapiens"
xref: Reactome:REACT_15543 "Cyclin B/Cdk1 mediate phosphorylation of NuMA, Homo sapiens"
xref: Reactome:REACT_1627 "Phosphorylation of proteins involved in G2/M transition by active Cyclin A2:Cdc2 complexes, Homo sapiens"
xref: Reactome:REACT_1882 "Cyclin D:Cdk4/6 mediated phosphorylation of Rb and dissociation of phospho-Rb from the E2F1/2/3:DP-1 complexes, Homo sapiens"
xref: Reactome:REACT_28043 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Rattus norvegicus"
xref: Reactome:REACT_28206 "Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21, Mus musculus"
xref: Reactome:REACT_28927 "Phosphorylation of M phase proteins by active Cyclin B1:Cdc2 complexes, Xenopus tropicalis"
xref: Reactome:REACT_29737 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Bos taurus"
xref: Reactome:REACT_30547 "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2, Mus musculus"
xref: Reactome:REACT_30560 "Free APC/C phosphorylated by Cyclin B:Cdc2, Mus musculus"
xref: Reactome:REACT_30857 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Canis familiaris"
xref: Reactome:REACT_30946 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Taeniopygia guttata"
xref: Reactome:REACT_31143 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Arabidopsis thaliana"
xref: Reactome:REACT_32944 "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2, Xenopus tropicalis"
xref: Reactome:REACT_33000 "Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21, Bos taurus"
xref: Reactome:REACT_33255 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Oryza sativa"
xref: Reactome:REACT_33633 "Cyclin E:Cdk2-mediated phosphorylation of Rb, Mus musculus"
xref: Reactome:REACT_33864 "Cyclin D:Cdk4/6 mediated phosphorylation of Rb and dissociation of phospho-Rb from the E2F1/2/3:DP-1 complexes, Bos taurus"
xref: Reactome:REACT_34028 "Free APC/C phosphorylated by Cyclin B:Cdc2, Danio rerio"
xref: Reactome:REACT_406 "Phosphorylation of proteins involved in G2/M transition by active Cyclin A1:Cdc2 complexes, Homo sapiens"
xref: Reactome:REACT_46105 "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160), Sus scrofa"
xref: Reactome:REACT_55912 "Cyclin A:Cdk2 mediated phosphorylation of p27/p21, Canis familiaris"
xref: Reactome:REACT_6338 "Phosphorylation of M phase proteins by active Cyclin B1:Cdc2 complexes, Homo sapiens"
xref: Reactome:REACT_6721 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Homo sapiens"
xref: Reactome:REACT_68077 "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160), Canis familiaris"
xref: Reactome:REACT_6811 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Homo sapiens"
xref: Reactome:REACT_6891 "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2, Homo sapiens"
xref: Reactome:REACT_6942 "Free APC/C phosphorylated by Cyclin B:Cdc2, Homo sapiens"
xref: Reactome:REACT_77008 "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160), Mus musculus"
xref: Reactome:REACT_77473 "Cyclin A:Cdk2 mediated phosphorylation of p27/p21, Bos taurus"
xref: Reactome:REACT_77863 "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2, Rattus norvegicus"
xref: Reactome:REACT_78910 "Free APC/C phosphorylated by Cyclin B:Cdc2, Xenopus tropicalis"
xref: Reactome:REACT_80990 "Free APC/C phosphorylated by Cyclin B:Cdc2, Drosophila melanogaster"
xref: Reactome:REACT_81918 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Drosophila melanogaster"
xref: Reactome:REACT_82302 "CDK5 phosphorylates DARPP-32 on Thr75, Mus musculus"
xref: Reactome:REACT_82539 "Phosphorylation of M phase proteins by active Cyclin B1:Cdc2 complexes, Drosophila melanogaster"
xref: Reactome:REACT_82578 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Danio rerio"
xref: Reactome:REACT_83958 "CDK5 phosphorylates DARPP-32 on Thr75, Bos taurus"
xref: Reactome:REACT_84020 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Xenopus tropicalis"
xref: Reactome:REACT_84061 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Rattus norvegicus"
xref: Reactome:REACT_84295 "Free APC/C phosphorylated by Cyclin B:Cdc2, Rattus norvegicus"
xref: Reactome:REACT_852 "Phosphorylation of proteins involved in G2/M transition by active Cyclin B2:Cdc2 complexes, Homo sapiens"
xref: Reactome:REACT_85707 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Canis familiaris"
xref: Reactome:REACT_85853 "Cyclin E:Cdk2-mediated phosphorylation of Rb, Rattus norvegicus"
xref: Reactome:REACT_86936 "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2, Danio rerio"
xref: Reactome:REACT_88269 "Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21, Sus scrofa"
xref: Reactome:REACT_88622 "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160), Bos taurus"
xref: Reactome:REACT_89028 "Cyclin E:Cdk2-mediated phosphorylation of Rb, Canis familiaris"
xref: Reactome:REACT_89106 "Cyclin E:Cdk2-mediated phosphorylation of Rb, Bos taurus"
xref: Reactome:REACT_89375 "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160), Danio rerio"
xref: Reactome:REACT_89502 "Phosphorylation of M phase proteins by active Cyclin B1:Cdc2 complexes, Bos taurus"
xref: Reactome:REACT_8993 "Cyclin E:Cdk2-mediated phosphorylation of Rb, Homo sapiens"
xref: Reactome:REACT_8995 "Cyclin A:Cdk2 mediated phosphorylation of p27/p21, Homo sapiens"
xref: Reactome:REACT_8998 "Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21, Homo sapiens"
xref: Reactome:REACT_9023 "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160), Homo sapiens"
xref: Reactome:REACT_91084 "Cyclin E:Cdk2-mediated phosphorylation of Rb, Sus scrofa"
xref: Reactome:REACT_91609 "Cyclin B/Cdk1 mediate phosphorylation of NuMA, Danio rerio"
xref: Reactome:REACT_92060 "Free APC/C phosphorylated by Cyclin B:Cdc2, Bos taurus"
xref: Reactome:REACT_93696 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Danio rerio"
xref: Reactome:REACT_93979 "Cyclin D:Cdk4/6 mediated phosphorylation of Rb and dissociation of phospho-Rb from the E2F1/2/3:DP-1 complexes, Mus musculus"
xref: Reactome:REACT_94092 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Xenopus tropicalis"
xref: Reactome:REACT_96284 "Free APC/C phosphorylated by Cyclin B:Cdc2, Canis familiaris"
xref: Reactome:REACT_96884 "CDK5 phosphorylates DARPP-32 on Thr75, Danio rerio"
xref: Reactome:REACT_96907 "Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21, Danio rerio"
xref: Reactome:REACT_98018 "Cyclin A:Cdk2 mediated phosphorylation of p27/p21, Xenopus tropicalis"
xref: Reactome:REACT_98320 "Cyclin B/Cdk1 mediate phosphorylation of NuMA, Canis familiaris"
xref: Reactome:REACT_98605 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Bos taurus"
xref: Reactome:REACT_99005 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Gallus gallus"
xref: Reactome:REACT_99017 "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2, Canis familiaris"
xref: Reactome:REACT_99668 "Cyclin A:Cdk2 mediated phosphorylation of p27/p21, Mus musculus"
is_a: GO:0004674 ! protein serine/threonine kinase activity
is_a: GO:0097472 ! cyclin-dependent protein kinase activity

[Term]
id: GO:0004694
name: eukaryotic translation initiation factor 2alpha kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + [eukaryotic translation initiation factor 2 alpha subunit] = ADP + [eukaryotic translation initiation factor 2 alpha subunit] phosphate." [GOC:mah, InterPro:IPR015516]
xref: EC:2.7.11.-
is_a: GO:0004674 ! protein serine/threonine kinase activity
relationship: part_of GO:0010998 ! regulation of translational initiation by eIF2 alpha phosphorylation

[Term]
id: GO:0004697
name: protein kinase C activity
namespace: molecular_function
alt_id: GO:0004701
def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol." [EC:2.7.11.13]
synonym: "ATP:protein phosphotransferase (diacylglycerol-dependent) activity" EXACT [EC:2.7.11.13]
synonym: "cPKC" RELATED [EC:2.7.11.13]
synonym: "cPKCalpha" RELATED [EC:2.7.11.13]
synonym: "cPKCbeta" RELATED [EC:2.7.11.13]
synonym: "cPKCgamma" RELATED [EC:2.7.11.13]
synonym: "diacylglycerol-activated phospholipid-dependent PKC activity" EXACT []
synonym: "diacylglycerol-activated phospholipid-dependent protein kinase C activity" EXACT []
synonym: "nPKC" RELATED [EC:2.7.11.13]
synonym: "nPKCdelta" RELATED [EC:2.7.11.13]
synonym: "nPKCepsilon" RELATED [EC:2.7.11.13]
synonym: "nPKCeta" RELATED [EC:2.7.11.13]
synonym: "nPKCtheta" RELATED [EC:2.7.11.13]
synonym: "PKC" RELATED [EC:2.7.11.13]
synonym: "PKC activity" EXACT []
synonym: "Pkc1p" RELATED [EC:2.7.11.13]
synonym: "PKCalpha" RELATED [EC:2.7.11.13]
synonym: "PKCbeta" RELATED [EC:2.7.11.13]
synonym: "PKCdelta" RELATED [EC:2.7.11.13]
synonym: "PKCepsilon" RELATED [EC:2.7.11.13]
synonym: "PKCgamma" RELATED [EC:2.7.11.13]
synonym: "PKCzeta" RELATED [EC:2.7.11.13]
synonym: "protein kinase Cepsilon activity" NARROW [EC:2.7.11.13]
synonym: "STK24" RELATED [EC:2.7.11.13]
xref: EC:2.7.11.13
xref: MetaCyc:2.7.11.13-RXN
xref: Reactome:REACT_103533 "DAG stimulates protein kinase C-delta, Xenopus tropicalis"
xref: Reactome:REACT_105098 "DAG stimulates protein kinase C-delta, Gallus gallus"
xref: Reactome:REACT_106910 "DAG stimulates protein kinase C-delta, Canis familiaris"
xref: Reactome:REACT_109828 "DAG stimulates protein kinase C-delta, Rattus norvegicus"
xref: Reactome:REACT_113213 "DAG stimulates protein kinase C-delta, Saccharomyces cerevisiae"
xref: Reactome:REACT_113684 "DAG stimulates protein kinase C-delta, Schizosaccharomyces pombe"
xref: Reactome:REACT_12062 "DAG stimulates protein kinase C-delta, Homo sapiens"
xref: Reactome:REACT_22249 "Gz is a substrate for PKC, Homo sapiens"
xref: Reactome:REACT_22404 "Gz (rat) is a substrate for PKC (cow), Bos taurus"
xref: Reactome:REACT_28264 "DAG stimulates protein kinase C-delta, Sus scrofa"
xref: Reactome:REACT_31700 "DAG stimulates protein kinase C-delta, Taeniopygia guttata"
xref: Reactome:REACT_80354 "DAG stimulates protein kinase C-delta, Caenorhabditis elegans"
xref: Reactome:REACT_95728 "DAG stimulates protein kinase C-delta, Danio rerio"
xref: Reactome:REACT_95817 "DAG stimulates protein kinase C-delta, Mus musculus"
xref: Reactome:REACT_98641 "DAG stimulates protein kinase C-delta, Drosophila melanogaster"
xref: Reactome:REACT_99453 "DAG stimulates protein kinase C-delta, Bos taurus"
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0004698
name: calcium-dependent protein kinase C activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol and calcium." [EC:2.7.11.13, GOC:mah]
synonym: "calcium-dependent PKC activity" EXACT []
synonym: "conventional protein kinase C activity" EXACT [PMID:9601053]
xref: EC:2.7.11.-
xref: Reactome:REACT_101052 "Phosphorylation of Platelet Sec-1, Xenopus tropicalis"
xref: Reactome:REACT_103140 "Endocytosis of Ca impermeable AMPA receptors, Canis familiaris"
xref: Reactome:REACT_103995 "Phosphorylation of Syntaxin-4, Danio rerio"
xref: Reactome:REACT_1045 "Phosphorylation of Syntaxin-4, Homo sapiens"
xref: Reactome:REACT_105213 "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites, Mus musculus"
xref: Reactome:REACT_105525 "Phosphorylation of Platelet Sec-1, Danio rerio"
xref: Reactome:REACT_106825 "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites, Gallus gallus"
xref: Reactome:REACT_106923 "Phosphorylation of Platelet Sec-1, Sus scrofa"
xref: Reactome:REACT_110338 "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites, Danio rerio"
xref: Reactome:REACT_111973 "Phosphorylation of Syntaxin-4, Saccharomyces cerevisiae"
xref: Reactome:REACT_111980 "Phosphorylation of Syntaxin-4, Schizosaccharomyces pombe"
xref: Reactome:REACT_112603 "Phosphorylation of Platelet Sec-1, Schizosaccharomyces pombe"
xref: Reactome:REACT_112939 "Endocytosis of Ca impermeable AMPA receptors, Xenopus tropicalis"
xref: Reactome:REACT_113338 "Phosphorylation of Platelet Sec-1, Saccharomyces cerevisiae"
xref: Reactome:REACT_115137 "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites, Xenopus tropicalis"
xref: Reactome:REACT_133 "Phosphorylation of Platelet Sec-1, Homo sapiens"
xref: Reactome:REACT_18308 "Endocytosis of Ca impermeable AMPA receptors, Homo sapiens"
xref: Reactome:REACT_18330 "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites, Homo sapiens"
xref: Reactome:REACT_29385 "Phosphorylation of Platelet Sec-1, Gallus gallus"
xref: Reactome:REACT_30032 "Phosphorylation of Syntaxin-4, Xenopus tropicalis"
xref: Reactome:REACT_30622 "Phosphorylation of Platelet Sec-1, Bos taurus"
xref: Reactome:REACT_30716 "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites, Bos taurus"
xref: Reactome:REACT_34250 "Phosphorylation of Platelet Sec-1, Mus musculus"
xref: Reactome:REACT_78075 "Endocytosis of Ca impermeable AMPA receptors, Taeniopygia guttata"
xref: Reactome:REACT_78325 "Endocytosis of Ca impermeable AMPA receptors, Mus musculus"
xref: Reactome:REACT_78640 "Endocytosis of Ca impermeable AMPA receptors, Gallus gallus"
xref: Reactome:REACT_78747 "Phosphorylation of Syntaxin-4, Bos taurus"
xref: Reactome:REACT_79502 "Phosphorylation of Platelet Sec-1, Rattus norvegicus"
xref: Reactome:REACT_80053 "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites, Rattus norvegicus"
xref: Reactome:REACT_82452 "Phosphorylation of Syntaxin-4, Canis familiaris"
xref: Reactome:REACT_82800 "Phosphorylation of Syntaxin-4, Mus musculus"
xref: Reactome:REACT_83817 "Phosphorylation of Syntaxin-4, Rattus norvegicus"
xref: Reactome:REACT_84126 "Endocytosis of Ca impermeable AMPA receptors, Rattus norvegicus"
xref: Reactome:REACT_86219 "Phosphorylation of Platelet Sec-1, Taeniopygia guttata"
xref: Reactome:REACT_88196 "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites, Taeniopygia guttata"
xref: Reactome:REACT_92512 "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites, Canis familiaris"
xref: Reactome:REACT_92539 "Endocytosis of Ca impermeable AMPA receptors, Drosophila melanogaster"
xref: Reactome:REACT_95680 "Phosphorylation of Platelet Sec-1, Canis familiaris"
xref: Reactome:REACT_95759 "Phosphorylation of Syntaxin-4, Sus scrofa"
xref: Reactome:REACT_96738 "Endocytosis of Ca impermeable AMPA receptors, Bos taurus"
xref: Reactome:REACT_97035 "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites, Drosophila melanogaster"
xref: Reactome:REACT_97700 "Endocytosis of Ca impermeable AMPA receptors, Danio rerio"
is_a: GO:0004697 ! protein kinase C activity
is_a: GO:0009931 ! calcium-dependent protein serine/threonine kinase activity

[Term]
id: GO:0004699
name: calcium-independent protein kinase C activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol but not calcium." [EC:2.7.11.13, GOC:mah]
synonym: "calcium-independent PKC activity" EXACT []
synonym: "novel protein kinase C activity" EXACT [PMID:9601053]
is_a: GO:0004697 ! protein kinase C activity

[Term]
id: GO:0004702
name: receptor signaling protein serine/threonine kinase activity
namespace: molecular_function
def: "Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.13, GOC:bf, GOC:mah]
synonym: "receptor signalling protein serine/threonine kinase activity" EXACT []
xref: EC:2.7.11.-
is_a: GO:0004674 ! protein serine/threonine kinase activity
is_a: GO:0005057 ! receptor signaling protein activity
relationship: part_of GO:0023014 ! signal transduction by protein phosphorylation

[Term]
id: GO:0004703
name: G-protein coupled receptor kinase activity
namespace: molecular_function
alt_id: GO:0004678
def: "Catalysis of the reaction: ATP + G-protein coupled receptor = ADP + G-protein coupled receptor phosphate." [GOC:dph]
synonym: "ATP:G-protein-coupled receptor phosphotransferase activity" EXACT [EC:2.7.11.16]
synonym: "G protein coupled receptor phosphorylating protein kinase activity" EXACT []
synonym: "G protein-coupled receptor kinase activity" EXACT [EC:2.7.11.16]
synonym: "G-protein-coupled receptor kinase activity" EXACT [EC:2.7.11.16]
synonym: "G-protein-coupled receptor phosphorylating protein kinase activity" EXACT []
synonym: "GPCR kinase activity" EXACT [EC:2.7.11.16]
synonym: "GPCR phosphorylating protein kinase activity" EXACT []
synonym: "GPCRK" RELATED [EC:2.7.11.16]
synonym: "GRK4" RELATED [EC:2.7.11.16]
synonym: "GRK5" RELATED [EC:2.7.11.16]
synonym: "GRK6" RELATED [EC:2.7.11.16]
synonym: "STK16" RELATED [EC:2.7.11.16]
xref: EC:2.7.11.16
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0004704
name: NF-kappaB-inducing kinase activity
namespace: molecular_function
def: "Catalysis of the phosphorylation of the alpha or beta subunit of the inhibitor of kappaB kinase complex (IKK)." [PMID:20685151]
synonym: "NIK" EXACT []
xref: EC:2.7.11.-
is_a: GO:0004702 ! receptor signaling protein serine/threonine kinase activity
relationship: part_of GO:0038061 ! NIK/NF-kappaB signaling

[Term]
id: GO:0004705
name: JUN kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: JUN + ATP = JUN phosphate + ADP. This reaction is the phosphorylation and activation of members of the JUN family, a gene family that encodes nuclear transcription factors." [GOC:bf, ISBN:0198506732]
synonym: "c-Jun N-terminal kinase activity" NARROW []
synonym: "JNK" EXACT []
synonym: "JNK3alpha1" RELATED []
synonym: "SAPK1" NARROW []
xref: EC:2.7.11.-
xref: Reactome:REACT_102468 "Activated JNKs phosphorylate c-JUN, Sus scrofa"
xref: Reactome:REACT_105521 "NRAGE activates JNK, Danio rerio"
xref: Reactome:REACT_107106 "Activated JNKs phosphorylate c-JUN, Canis familiaris"
xref: Reactome:REACT_107943 "NRAGE activates JNK, Mus musculus"
xref: Reactome:REACT_110914 "NRIF and TRAF6 may activate JNK, Danio rerio"
xref: Reactome:REACT_113885 "JNK phosphorylates BIM, BAD and other targets, Xenopus tropicalis"
xref: Reactome:REACT_13422 "NRIF and TRAF6 may activate JNK, Homo sapiens"
xref: Reactome:REACT_13427 "NRAGE activates JNK, Homo sapiens"
xref: Reactome:REACT_13660 "NRIF and TRAF6 may activate JNK, Mus musculus"
xref: Reactome:REACT_13777 "JNK phosphorylates BIM, BAD and other targets, Homo sapiens"
xref: Reactome:REACT_13804 "Nrage activates Jnk1, Rattus norvegicus"
xref: Reactome:REACT_25133 "Activation and dimerization of c-JUN in the nucleus, Gallus gallus"
xref: Reactome:REACT_28274 "NRIF and TRAF6 may activate JNK, Canis familiaris"
xref: Reactome:REACT_28873 "NRAGE activates JNK, Bos taurus"
xref: Reactome:REACT_29090 "JNK phosphorylates BIM, BAD and other targets, Rattus norvegicus"
xref: Reactome:REACT_30421 "NRIF and TRAF6 may activate JNK, Xenopus tropicalis"
xref: Reactome:REACT_31657 "JNK phosphorylates BIM, BAD and other targets, Sus scrofa"
xref: Reactome:REACT_33342 "NRIF and TRAF6 may activate JNK, Bos taurus"
xref: Reactome:REACT_34178 "Activated JNKs phosphorylate c-JUN, Bos taurus"
xref: Reactome:REACT_6716 "Activated JNKs phosphorylate c-JUN, Homo sapiens"
xref: Reactome:REACT_82416 "NRIF and TRAF6 may activate JNK, Gallus gallus"
xref: Reactome:REACT_84873 "Activated JNKs phosphorylate c-JUN, Danio rerio"
xref: Reactome:REACT_89073 "NRIF and TRAF6 may activate JNK, Rattus norvegicus"
xref: Reactome:REACT_89150 "Activated JNKs phosphorylate c-JUN, Taeniopygia guttata"
xref: Reactome:REACT_89326 "Activated JNKs phosphorylate c-JUN, Gallus gallus"
xref: Reactome:REACT_89545 "JNK phosphorylates BIM, BAD and other targets, Mus musculus"
xref: Reactome:REACT_89768 "NRIF and TRAF6 may activate JNK, Taeniopygia guttata"
xref: Reactome:REACT_90609 "Activated JNKs phosphorylate c-JUN, Xenopus tropicalis"
xref: Reactome:REACT_91285 "Activated JNKs phosphorylate c-JUN, Rattus norvegicus"
xref: Reactome:REACT_92150 "NRIF and TRAF6 may activate JNK, Sus scrofa"
xref: Reactome:REACT_92530 "JNK phosphorylates BIM, BAD and other targets, Canis familiaris"
xref: Reactome:REACT_93380 "JNK phosphorylates BIM, BAD and other targets, Bos taurus"
xref: Reactome:REACT_93451 "Activated JNKs phosphorylate c-JUN, Mus musculus"
xref: Reactome:REACT_94744 "NRAGE activates JNK, Xenopus tropicalis"
xref: Reactome:REACT_97463 "NRAGE activates JNK, Canis familiaris"
xref: Reactome:REACT_99495 "NRAGE activates JNK, Sus scrofa"
is_a: GO:0016909 ! SAP kinase activity
relationship: part_of GO:0007258 ! JUN phosphorylation

[Term]
id: GO:0004706
name: JUN kinase kinase kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: JNKK + ATP = JNKK phosphate + ADP. This reaction is the phosphorylation and activation of JUN kinase kinases (JNKKs)." [GOC:bf]
synonym: "JNK kinase kinase activity" RELATED []
synonym: "JNKKK" EXACT []
xref: EC:2.7.11.-
is_a: GO:0004709 ! MAP kinase kinase kinase activity
relationship: part_of GO:0007256 ! activation of JNKK activity

[Term]
id: GO:0004707
name: MAP kinase activity
namespace: molecular_function
alt_id: GO:0008338
alt_id: GO:0008339
alt_id: GO:0016908
def: "Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli." [GOC:ma, ISBN:0198547684]
synonym: "ATP:protein phosphotransferase (MAPKK-activated) activity" EXACT [EC:2.7.11.24]
synonym: "Dp38" RELATED [EC:2.7.11.24]
synonym: "ERK" RELATED [EC:2.7.11.24]
synonym: "ERK1" EXACT []
synonym: "ERK2" RELATED []
synonym: "extracellular signal-regulated kinase activity" NARROW [EC:2.7.11.24]
synonym: "LeMPK3" RELATED [EC:2.7.11.24]
synonym: "MAP kinase 1 activity" NARROW []
synonym: "MAP kinase 2 activity" NARROW []
synonym: "MAP-2 kinase activity" NARROW [EC:2.7.11.24]
synonym: "MAPK" RELATED [EC:2.7.11.24, PMID:20811974]
synonym: "MBP kinase I activity" NARROW [EC:2.7.11.24]
synonym: "MBP kinase II activity" NARROW [EC:2.7.11.24]
synonym: "mitogen activated kinase activity" EXACT []
synonym: "mitogen-activated protein kinase activity" EXACT [EC:2.7.11.24]
synonym: "MP kinase activity" NARROW []
synonym: "Mpk2" NARROW []
synonym: "myelin basic protein kinase activity" NARROW [EC:2.7.11.24]
synonym: "p38" NARROW []
synonym: "p38-2" RELATED [EC:2.7.11.24]
synonym: "p38delta" RELATED [EC:2.7.11.24]
synonym: "p42 mitogen-activated protein kinase activity" NARROW [EC:2.7.11.24]
synonym: "p42mapk" RELATED [EC:2.7.11.24]
synonym: "p44mpk" RELATED [EC:2.7.11.24]
synonym: "PMK-1" RELATED [EC:2.7.11.24]
synonym: "PMK-2" RELATED [EC:2.7.11.24]
synonym: "PMK-3" RELATED [EC:2.7.11.24]
synonym: "pp42" RELATED [EC:2.7.11.24]
synonym: "pp44mapk" RELATED [EC:2.7.11.24]
synonym: "SAPK2" NARROW []
synonym: "STK26" RELATED [EC:2.7.11.24]
xref: EC:2.7.11.24
xref: KEGG:R00162
xref: MetaCyc:2.7.11.24-RXN
xref: Reactome:REACT_100829 "ERK5 is activated, Oryza sativa"
xref: Reactome:REACT_104581 "ERK5 is activated, Arabidopsis thaliana"
xref: Reactome:REACT_111161 "Activated ERK1/2 threonine-phosphorylate FRS2alpha., Homo sapiens"
xref: Reactome:REACT_115393 "Phosphorylation of UBF-1:rDNA Promoter, Rattus norvegicus"
xref: Reactome:REACT_12075 "ERK5 is activated, Homo sapiens"
xref: Reactome:REACT_12418 "ERK5 is activated, Rattus norvegicus"
xref: Reactome:REACT_180 "Phosphorylation of UBF-1:rDNA Promoter, Homo sapiens"
xref: Reactome:REACT_25129 "Activation of p38MAPK by DSCAM, Homo sapiens"
xref: Reactome:REACT_29583 "Phosphorylation of UBF-1:rDNA Promoter, Danio rerio"
xref: Reactome:REACT_30765 "Phosphorylation of UBF-1:rDNA Promoter, Canis familiaris"
xref: Reactome:REACT_31584 "Phosphorylation of UBF-1:rDNA Promoter, Bos taurus"
xref: Reactome:REACT_80477 "ERK5 is activated, Danio rerio"
xref: Reactome:REACT_82316 "Activation of p38MAPK by DSCAM, Rattus norvegicus"
xref: Reactome:REACT_83043 "ERK5 is activated, Xenopus tropicalis"
xref: Reactome:REACT_87321 "ERK5 is activated, Mus musculus"
xref: Reactome:REACT_91897 "ERK5 is activated, Bos taurus"
xref: Reactome:REACT_98528 "ERK5 is activated, Canis familiaris"
xref: Reactome:REACT_99483 "ERK5 is activated, Dictyostelium discoideum"
xref: Reactome:REACT_99569 "Phosphorylation of UBF-1:rDNA Promoter, Mus musculus"
is_a: GO:0004702 ! receptor signaling protein serine/threonine kinase activity
relationship: part_of GO:0000165 ! MAPK cascade

[Term]
id: GO:0004708
name: MAP kinase kinase activity
namespace: molecular_function
def: "Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate." [ISBN:0198547684]
synonym: "ATP:protein phosphotransferase (MAPKKK-activated) activity" EXACT [EC:2.7.12.2]
synonym: "ERK activator kinase activity" EXACT []
synonym: "MAP kinase kinase 4 activity" NARROW [EC:2.7.12.2]
synonym: "MAP kinase kinase 7 activity" NARROW [EC:2.7.12.2]
synonym: "MAP kinase or ERK kinase activity" RELATED [EC:2.7.12.2]
synonym: "MAP2K" RELATED [EC:2.7.12.2]
synonym: "MAPK activator activity" EXACT [GOC:vw]
synonym: "MAPKK" RELATED [EC:2.7.12.2, PMID:20811974]
synonym: "MAPKK activity" EXACT []
synonym: "MAPKK1" RELATED [EC:2.7.12.2]
synonym: "MEK activity" BROAD []
synonym: "MEK1" RELATED [EC:2.7.12.2]
synonym: "MEK2" RELATED [EC:2.7.12.2]
synonym: "mitogen-activated protein kinase kinase activity" EXACT [EC:2.7.12.2]
synonym: "MKK" RELATED [EC:2.7.12.2]
synonym: "MKK2" RELATED [EC:2.7.12.2]
synonym: "MKK4" RELATED [EC:2.7.12.2]
synonym: "MKK6" RELATED [EC:2.7.12.2]
synonym: "MKK7" RELATED [EC:2.7.12.2]
synonym: "STK27" RELATED [EC:2.7.12.2]
xref: EC:2.7.11.-
xref: MetaCyc:2.7.12.2-RXN
xref: Reactome:REACT_21301 "Activation of p38 alpha/beta MAPK, Homo sapiens"
xref: Reactome:REACT_21350 "Activation of p38 alpha/beta MAPK, Mus musculus"
xref: Reactome:REACT_75807 "Activation of p38 MAPK, Homo sapiens"
is_a: GO:0004712 ! protein serine/threonine/tyrosine kinase activity
is_a: GO:0005057 ! receptor signaling protein activity
relationship: part_of GO:0000165 ! MAPK cascade
relationship: part_of GO:0000187 ! activation of MAPK activity

[Term]
id: GO:0004709
name: MAP kinase kinase kinase activity
namespace: molecular_function
alt_id: GO:0004710
def: "Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases." [PMID:9561267]
synonym: "ATP:protein phosphotransferase (MAPKKKK-activated) activity" EXACT [EC:2.7.11.25]
synonym: "cMos" RELATED [EC:2.7.11.25]
synonym: "cRaf" RELATED [EC:2.7.11.25]
synonym: "MAP3K" RELATED [EC:2.7.11.25, PMID:20811974]
synonym: "MAPK/ERK kinase kinase activity" EXACT []
synonym: "MAPKKK activity" EXACT [EC:2.7.11.25]
synonym: "MEK kinase activity" EXACT [EC:2.7.11.25]
synonym: "MEKK" RELATED [EC:2.7.11.25]
synonym: "MEKK activity" EXACT []
synonym: "MEKK1" RELATED [EC:2.7.11.25]
synonym: "MEKK2" RELATED [EC:2.7.11.25]
synonym: "MEKK3" RELATED [EC:2.7.11.25]
synonym: "Mil/Raf" RELATED [EC:2.7.11.25]
synonym: "mitogen-activated protein kinase kinase kinase activity" EXACT [EC:2.7.11.25]
synonym: "MLK-like mitogen-activated protein triple kinase activity" NARROW [EC:2.7.11.25]
synonym: "MLTK" RELATED [EC:2.7.11.25]
synonym: "MLTKa" RELATED [EC:2.7.11.25]
synonym: "MLTKb" RELATED [EC:2.7.11.25]
synonym: "REKS" RELATED [EC:2.7.11.25]
synonym: "STK28" RELATED [EC:2.7.11.25]
xref: EC:2.7.11.-
xref: EC:2.7.11.25
xref: MetaCyc:2.7.11.25-RXN
xref: Reactome:REACT_105756 "Akt:pCot phosphorylates NIK, Xenopus tropicalis"
xref: Reactome:REACT_107518 "Akt:pCot phosphorylates NIK, Bos taurus"
xref: Reactome:REACT_108303 "Akt:pCot phosphorylates NIK, Mus musculus"
xref: Reactome:REACT_114785 "Akt:pCot phosphorylates NIK, Gallus gallus"
xref: Reactome:REACT_19141 "Akt:pCot phosphorylates NIK, Homo sapiens"
xref: Reactome:REACT_22190 "TAK1 phosphorylates MKK6, Homo sapiens"
xref: Reactome:REACT_22271 "TPL2 phosphorylates MEK1, SEK1, Homo sapiens"
xref: Reactome:REACT_22411 "Tpl2 phosphorylates Mek1, Sek1, Mus musculus"
xref: Reactome:REACT_81738 "Akt:pCot phosphorylates NIK, Rattus norvegicus"
xref: Reactome:REACT_85351 "Akt:pCot phosphorylates NIK, Canis familiaris"
xref: Reactome:REACT_85999 "Akt:pCot phosphorylates NIK, Taeniopygia guttata"
is_a: GO:0004702 ! receptor signaling protein serine/threonine kinase activity
relationship: part_of GO:0000165 ! MAPK cascade
relationship: part_of GO:0000186 ! activation of MAPKK activity

[Term]
id: GO:0004711
name: ribosomal protein S6 kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ribosomal protein S6 + ATP = ribosomal protein S6 phosphate + ATP." [GOC:mah, PMID:9822608]
xref: EC:2.7.11.-
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0004712
name: protein serine/threonine/tyrosine kinase activity
namespace: molecular_function
def: "Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [GOC:mah]
subset: gosubset_prok
synonym: "ADK1" RELATED [EC:2.7.12.1]
synonym: "Arabidopsis dual specificity kinase 1 activity" NARROW [EC:2.7.12.1]
synonym: "ATP:protein phosphotransferase (Ser/Thr- and Tyr-phosphorylating) activity" EXACT [EC:2.7.12.1]
synonym: "CLK1" RELATED [EC:2.7.12.1]
synonym: "dDYRK2" RELATED [EC:2.7.12.1]
synonym: "dual-specificity kinase activity" BROAD [EC:2.7.12.1]
synonym: "dual-specificity protein kinase" BROAD []
synonym: "Mps1p" RELATED [EC:2.7.12.1]
synonym: "protein threonine/tyrosine kinase activity" NARROW []
xref: EC:2.7.12.1
xref: Reactome:REACT_21395 "activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3, Homo sapiens"
xref: Reactome:REACT_25052 "Active p38 MAPK phosphorylates MAPKAPK2 or 3, Gallus gallus"
xref: Reactome:REACT_25054 "activated chicken MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3, Gallus gallus"
xref: Reactome:REACT_25107 "MKK4 phosphorylates JNK, Gallus gallus"
xref: Reactome:REACT_36431 "activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3, Bos taurus"
xref: Reactome:REACT_84278 "activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3, Gallus gallus"
xref: Reactome:REACT_85777 "activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3, Taeniopygia guttata"
xref: Reactome:REACT_88248 "activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3, Rattus norvegicus"
xref: Reactome:REACT_90256 "activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3, Mus musculus"
xref: Reactome:REACT_91195 "activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3, Drosophila melanogaster"
xref: Reactome:REACT_92829 "activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3, Canis familiaris"
is_a: GO:0004672 ! protein kinase activity

[Term]
id: GO:0004713
name: protein tyrosine kinase activity
namespace: molecular_function
alt_id: GO:0004718
def: "Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]
subset: gosubset_prok
synonym: "JAK" NARROW []
synonym: "Janus kinase activity" NARROW []
synonym: "protein-tyrosine kinase activity" EXACT []
xref: EC:2.7.10
xref: Reactome:REACT_100012 "Fyn/Lyn-mediated phosphorylation of FcR1 gamma, Canis familiaris"
xref: Reactome:REACT_100028 "Phosphorylation of DCC by Fyn, Bos taurus"
xref: Reactome:REACT_100038 "Phosphorylation of nephrin by the Src family kinase Fyn, Bos taurus"
xref: Reactome:REACT_100076 "Syk/Lck phosphorylate LAT, Mus musculus"
xref: Reactome:REACT_100084 "Autophosphorylation of NCAM1 bound Fyn, Danio rerio"
xref: Reactome:REACT_100130 "Autophosphorylation of PDGF alpha receptors, Gallus gallus"
xref: Reactome:REACT_100272 "Phosphorylation of PLC-gamma1, Canis familiaris"
xref: Reactome:REACT_100472 "Tyrosine phosphorylation of CRMPs by Fes, Sus scrofa"
xref: Reactome:REACT_100650 "Binding and activation of MAP Kinase, Xenopus tropicalis"
xref: Reactome:REACT_100799 "Phosphorylation of L1 by EPHB2, Mus musculus"
xref: Reactome:REACT_100803 "Activation of Vav1, Mus musculus"
xref: Reactome:REACT_100852 "Phosphorylation of PLC-gamma1, Bos taurus"
xref: Reactome:REACT_100858 "Autocatalytic phosphorylation of FGFR1b, Xenopus tropicalis"
xref: Reactome:REACT_100859 "PLC gamma phosphorylation by FGFR, Sus scrofa"
xref: Reactome:REACT_100890 "Autocatalytic phosphorylation of Klotho-bound FGFR1c, Xenopus tropicalis"
xref: Reactome:REACT_100893 "Autophosphorylation of PDGF alpha/beta receptors, Rattus norvegicus"
xref: Reactome:REACT_100943 "Autocatalytic phosphorylation of FGFR2b, Mus musculus"
xref: Reactome:REACT_100947 "EGFR autophosphorylation, Gallus gallus"
xref: Reactome:REACT_101042 "Phosphorylation of EGFR by SRC kinase, Taeniopygia guttata"
xref: Reactome:REACT_101080 "Phosphorylation of CTLA-4, Bos taurus"
xref: Reactome:REACT_101097 "Autocatalytic phosphorylation of FGFR2c, Rattus norvegicus"
xref: Reactome:REACT_101231 "Autocatalytic phosphorylation of FGFR1b, Sus scrofa"
xref: Reactome:REACT_101274 "SEMA4D interacts with Plexin-B1:ErbB2, Xenopus tropicalis"
xref: Reactome:REACT_101384 "Autocatalytic phosphorylation of FGFR2b, Danio rerio"
xref: Reactome:REACT_101466 "Phosphorylation of FRS2-alpha by activated FGFR, Bos taurus"
xref: Reactome:REACT_101595 "Phosphorylation of nephrin by the Src family kinase Fyn, Sus scrofa"
xref: Reactome:REACT_101612 "Phosphorylation of CTLA-4, Rattus norvegicus"
xref: Reactome:REACT_101643 "Phosphorylation of FRS2-alpha by activated FGFR, Rattus norvegicus"
xref: Reactome:REACT_101668 "Phosphorylation of Rob1 by Abl kinase, Canis familiaris"
xref: Reactome:REACT_101714 "Autocatalytic phosphorylation of FGFR4, Bos taurus"
xref: Reactome:REACT_101813 "Autophosphorylation of SRC, Bos taurus"
xref: Reactome:REACT_101985 "Autocatalytic phosphorylation of FGFR3c, Xenopus tropicalis"
xref: Reactome:REACT_102066 "Activation of ZAP-70, Mus musculus"
xref: Reactome:REACT_102080 "Autocatalytic phosphorylation of FGFR1b, Bos taurus"
xref: Reactome:REACT_102206 "Tyrosine phosphorylation of CRMPs by Fes, Xenopus tropicalis"
xref: Reactome:REACT_102366 "Trans-phosphorylation of Tie2, Danio rerio"
xref: Reactome:REACT_102431 "Phosphorylation of DCC by Fyn, Mus musculus"
xref: Reactome:REACT_102446 "Autophosphorylation of PDGF beta receptors, Rattus norvegicus"
xref: Reactome:REACT_102451 "Phosphorylation of FRS2-alpha by activated FGFR, Canis familiaris"
xref: Reactome:REACT_102485 "EGFR activates PLC-gamma1 by phosphorylation, Mus musculus"
xref: Reactome:REACT_102490 "Autophosphorylation of NCAM1 bound Fyn, Xenopus tropicalis"
xref: Reactome:REACT_102575 "FGR binds and phosphorylates ApoER2, Xenopus tropicalis"
xref: Reactome:REACT_102756 "Phosphorylation of FADK1, Sus scrofa"
xref: Reactome:REACT_103001 "Autocatalytic phosphorylation of FGFR3b, Taeniopygia guttata"
xref: Reactome:REACT_103159 "Phosphorylation of nephrin by the Src family kinase Fyn, Rattus norvegicus"
xref: Reactome:REACT_103330 "Phosphorylation of Plexin-A, Taeniopygia guttata"
xref: Reactome:REACT_103364 "Trans-phosphorylation of Tie2, Taeniopygia guttata"
xref: Reactome:REACT_103374 "SEMA4D interacts with Plexin-B1:ErbB2, Mus musculus"
xref: Reactome:REACT_103435 "Autocatalytic phosphorylation of FGFR1c, Sus scrofa"
xref: Reactome:REACT_103496 "Autocatalytic phosphorylation of FGFR1c, Gallus gallus"
xref: Reactome:REACT_103654 "Phosphorylation of Rob1 by Abl kinase, Drosophila melanogaster"
xref: Reactome:REACT_103887 "Trans-phosphorylation of Tie2, Sus scrofa"
xref: Reactome:REACT_103906 "Phosphorylation of PLC-gamma1, Mus musculus"
xref: Reactome:REACT_103917 "Autocatalytic phosphorylation of FGFR2b, Bos taurus"
xref: Reactome:REACT_104292 "Phosphorylation of EGFR by SRC kinase, Danio rerio"
xref: Reactome:REACT_104626 "PLC gamma phosphorylation by FGFR, Rattus norvegicus"
xref: Reactome:REACT_104628 "Phosphorylation of TBSMs in LAT, Rattus norvegicus"
xref: Reactome:REACT_104726 "SYK activation by SRC, Xenopus tropicalis"
xref: Reactome:REACT_104756 "SYK activation by SRC, Bos taurus"
xref: Reactome:REACT_104841 "Activation of SRC by RAL-GTP, Taeniopygia guttata"
xref: Reactome:REACT_104863 "Autocatalytic phosphorylation of FGFR2b, Sus scrofa"
xref: Reactome:REACT_104977 "Autocatalytic phosphorylation of FGFR1b, Rattus norvegicus"
xref: Reactome:REACT_105013 "Phosphorylation of CTLA-4, Mus musculus"
xref: Reactome:REACT_105509 "SHP2 is phosphorylated by activated FGFR, Rattus norvegicus"
xref: Reactome:REACT_105547 "Autocatalytic phosphorylation of FGFR1b, Danio rerio"
xref: Reactome:REACT_105559 "Autocatalytic phosphorylation of Klotho-bound FGFR1c, Rattus norvegicus"
xref: Reactome:REACT_105866 "Phosphorylation of Rob1 by Abl kinase, Caenorhabditis elegans"
xref: Reactome:REACT_105876 "SEMA4D interacts with Plexin-B1:ErbB2, Canis familiaris"
xref: Reactome:REACT_105927 "Phosphorylation of CTLA-4, Canis familiaris"
xref: Reactome:REACT_106169 "Autocatalytic phosphorylation of FGFR1b, Canis familiaris"
xref: Reactome:REACT_106379 "Phosphorylation of CBL (EGFR:CBL), Xenopus tropicalis"
xref: Reactome:REACT_106547 "EGFR autophosphorylation, Mus musculus"
xref: Reactome:REACT_106775 "Tyrosine phosphorylation of CRMPs by Fes, Rattus norvegicus"
xref: Reactome:REACT_107007 "SYK activation by SRC, Canis familiaris"
xref: Reactome:REACT_107187 "Phosphorylation of ITAM motifs in CD3 complexes, Mus musculus"
xref: Reactome:REACT_107212 "Phosphorylation of ZAP-70 by Lck, Mus musculus"
xref: Reactome:REACT_107285 "SHP2 is phosphorylated by activated FGFR, Bos taurus"
xref: Reactome:REACT_107298 "EGFR activates PLC-gamma1 by phosphorylation, Gallus gallus"
xref: Reactome:REACT_107312 "Phosphorylation of FRS2-alpha by activated FGFR, Drosophila melanogaster"
xref: Reactome:REACT_107327 "Activation of Vav1, Bos taurus"
xref: Reactome:REACT_107342 "Phosphorylation of FRS2-alpha by activated FGFR, Mus musculus"
xref: Reactome:REACT_107458 "Activation of SRC by RAL-GTP, Bos taurus"
xref: Reactome:REACT_107484 "Phosphorylation of CD28, Bos taurus"
xref: Reactome:REACT_107485 "Phosphorylation of Rob1 by Abl kinase, Xenopus tropicalis"
xref: Reactome:REACT_107535 "SHP2 is phosphorylated by activated FGFR, Xenopus tropicalis"
xref: Reactome:REACT_107546 "Phosphorylation of DCC by Fyn, Rattus norvegicus"
xref: Reactome:REACT_107572 "EGFR autophosphorylation, Taeniopygia guttata"
xref: Reactome:REACT_107798 "Activation of Src, Danio rerio"
xref: Reactome:REACT_107837 "Phosphorylation of FRS2-alpha by activated FGFR, Danio rerio"
xref: Reactome:REACT_107848 "SEMA4D interacts with Plexin-B1:Met, Mus musculus"
xref: Reactome:REACT_107881 "Phosphorylation of DCC by Fyn, Drosophila melanogaster"
xref: Reactome:REACT_108123 "Autocatalytic phosphorylation of FGFR1c, Mus musculus"
xref: Reactome:REACT_108224 "SHP2 is phosphorylated by activated FGFR, Drosophila melanogaster"
xref: Reactome:REACT_108225 "Autocatalytic phosphorylation of FGFR4, Mus musculus"
xref: Reactome:REACT_108245 "Tyrosine phosphorylation of CRMPs by Fes, Bos taurus"
xref: Reactome:REACT_108324 "FGR binds and phosphorylates ApoER2, Canis familiaris"
xref: Reactome:REACT_108410 "Autophosphorylation of NCAM1 bound Fyn, Gallus gallus"
xref: Reactome:REACT_108600 "Autophosphorylation of PDGF alpha receptors, Canis familiaris"
xref: Reactome:REACT_108669 "Recruitment of FAK to NCAM1:Fyn in lipid rafts, Xenopus tropicalis"
xref: Reactome:REACT_108733 "Phosphorylation of nephrin by the Src family kinase Fyn, Mus musculus"
xref: Reactome:REACT_108819 "Trans-phosphorylation of Tie2, Canis familiaris"
xref: Reactome:REACT_108838 "Autocatalytic phosphorylation of FGFR4, Sus scrofa"
xref: Reactome:REACT_108934 "Autocatalytic phosphorylation of FGFR2c, Mus musculus"
xref: Reactome:REACT_109237 "Phosphorylation of CBL (EGFR:GRB2:CBL), Mus musculus"
xref: Reactome:REACT_109581 "Syk/Lck phosphorylate LAT, Bos taurus"
xref: Reactome:REACT_109591 "Phosphorylation of L1 by SRC, Canis familiaris"
xref: Reactome:REACT_109753 "Autophosphorylation of NCAM1 bound Fyn, Taeniopygia guttata"
xref: Reactome:REACT_110118 "Binding and activation of MAP Kinase, Sus scrofa"
xref: Reactome:REACT_110259 "Activation of SRC by RAL-GTP, Danio rerio"
xref: Reactome:REACT_110475 "Autocatalytic phosphorylation of FGFR4, Canis familiaris"
xref: Reactome:REACT_111020 "PLC gamma phosphorylation by FGFR, Taeniopygia guttata"
xref: Reactome:REACT_111028 "Phosphorylation of L1 by SRC, Xenopus tropicalis"
xref: Reactome:REACT_111070 "Phosphorylation of JAK2, Homo sapiens"
xref: Reactome:REACT_111072 "Phosphorylation and activation of VAV1, Homo sapiens"
xref: Reactome:REACT_111096 "SRC phosphorylates SPRY2 on Y55 and Y227, Homo sapiens"
xref: Reactome:REACT_111103 "Autophosphorylation of KIT, Homo sapiens"
xref: Reactome:REACT_111110 "SHC1 is phosphorylated, Homo sapiens"
xref: Reactome:REACT_111112 "Phosphorylation of APS, Homo sapiens"
xref: Reactome:REACT_111134 "Phosphorylation of PLCgamma by PDGFR, Homo sapiens"
xref: Reactome:REACT_111147 "JAK2 phosphorylation of GHR, Homo sapiens"
xref: Reactome:REACT_111152 "Phosphorylation of SHP2 by SFKs, Homo sapiens"
xref: Reactome:REACT_111186 "Phosphorylation of GAB2 by SFKs, Homo sapiens"
xref: Reactome:REACT_111201 "Phosphorylation of FRS2-beta by activated FGFR, Homo sapiens"
xref: Reactome:REACT_111218 "STAT5 tyrosine phosphorylation, Homo sapiens"
xref: Reactome:REACT_111244 "Phosphorylation of STATs, Homo sapiens"
xref: Reactome:REACT_111246 "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4, Homo sapiens"
xref: Reactome:REACT_111958 "Phosphorylation of APS, Rattus norvegicus"
xref: Reactome:REACT_112027 "Autophosphorylation of KIT, Xenopus tropicalis"
xref: Reactome:REACT_112044 "Autocatalytic phosphorylation of FGFR2b, Caenorhabditis elegans"
xref: Reactome:REACT_112047 "Phosphorylation of Unc5C, Gallus gallus"
xref: Reactome:REACT_112071 "Phosphorylation and activation of VAV1, Canis familiaris"
xref: Reactome:REACT_112170 "Binding and activation of MAP Kinase, Oryza sativa"
xref: Reactome:REACT_112193 "Autophosphorylation of KIT, Rattus norvegicus"
xref: Reactome:REACT_112269 "Phosphorylation of L1 by SRC, Drosophila melanogaster"
xref: Reactome:REACT_112299 "PLC gamma phosphorylation by FGFR, Drosophila melanogaster"
xref: Reactome:REACT_112349 "SYK activation by SRC, Drosophila melanogaster"
xref: Reactome:REACT_112362 "Phosphorylation of FADK1, Xenopus tropicalis"
xref: Reactome:REACT_112411 "PLC gamma phosphorylation by FGFR, Caenorhabditis elegans"
xref: Reactome:REACT_112557 "Autocatalytic phosphorylation of FGFR4, Caenorhabditis elegans"
xref: Reactome:REACT_112582 "Phosphorylation of FRS2-beta by activated FGFR, Drosophila melanogaster"
xref: Reactome:REACT_112962 "Phosphorylation of APS, Bos taurus"
xref: Reactome:REACT_112967 "Phosphorylation of APS, Canis familiaris"
xref: Reactome:REACT_113016 "Phosphorylation of FRS2-beta by activated FGFR, Gallus gallus"
xref: Reactome:REACT_113054 "Autocatalytic phosphorylation of FGFR3c, Caenorhabditis elegans"
xref: Reactome:REACT_113122 "Autocatalytic phosphorylation of FGFR1c, Caenorhabditis elegans"
xref: Reactome:REACT_113138 "Phosphorylation of FRS2-beta by activated FGFR, Caenorhabditis elegans"
xref: Reactome:REACT_113262 "Phosphorylation of APS, Xenopus tropicalis"
xref: Reactome:REACT_113363 "Phosphorylation of nephrin by the Src family kinase Fyn, Xenopus tropicalis"
xref: Reactome:REACT_113366 "Phosphorylation of nephrin by the Src family kinase Fyn, Caenorhabditis elegans"
xref: Reactome:REACT_113372 "Phosphorylation of L1 by SRC, Caenorhabditis elegans"
xref: Reactome:REACT_113384 "Autophosphorylation of SRC, Xenopus tropicalis"
xref: Reactome:REACT_113409 "Autophosphorylation of KIT, Canis familiaris"
xref: Reactome:REACT_113474 "Autophosphorylation of KIT, Gallus gallus"
xref: Reactome:REACT_113502 "Phosphorylation of FAK by Src kinase, Drosophila melanogaster"
xref: Reactome:REACT_113605 "Phosphorylation and activation of VAV1, Mus musculus"
xref: Reactome:REACT_113630 "Phosphorylation and activation of VAV1, Xenopus tropicalis"
xref: Reactome:REACT_113647 "Autophosphorylation of KIT, Taeniopygia guttata"
xref: Reactome:REACT_113655 "Autophosphorylation of KIT, Mus musculus"
xref: Reactome:REACT_113678 "SHP2 is phosphorylated by activated FGFR, Caenorhabditis elegans"
xref: Reactome:REACT_113688 "Phosphorylation of ITIM in SIRP alpha, Sus scrofa"
xref: Reactome:REACT_113709 "Phosphorylation of CD28, Xenopus tropicalis"
xref: Reactome:REACT_113738 "Autophosphorylation of KIT, Sus scrofa"
xref: Reactome:REACT_113759 "Phosphorylation of ITIM in SIRP alpha, Taeniopygia guttata"
xref: Reactome:REACT_113828 "Autophosphorylation of PDGF beta receptors, Xenopus tropicalis"
xref: Reactome:REACT_113861 "Phosphorylation of APS, Gallus gallus"
xref: Reactome:REACT_113884 "Phosphorylation of APS, Sus scrofa"
xref: Reactome:REACT_113926 "Phosphorylation of APS, Mus musculus"
xref: Reactome:REACT_114012 "Phosphorylation of FRS2-beta by activated FGFR, Canis familiaris"
xref: Reactome:REACT_114045 "Autocatalytic phosphorylation of FGFR1b, Caenorhabditis elegans"
xref: Reactome:REACT_114111 "Phosphorylation of Unc5C, Drosophila melanogaster"
xref: Reactome:REACT_114124 "Phosphorylation of PLC-gamma1, Xenopus tropicalis"
xref: Reactome:REACT_114129 "Phosphorylation of FRS2-alpha by activated FGFR, Caenorhabditis elegans"
xref: Reactome:REACT_114167 "Phosphorylation of APS, Danio rerio"
xref: Reactome:REACT_114185 "Phosphorylation of nephrin by the Src family kinase Fyn, Drosophila melanogaster"
xref: Reactome:REACT_114530 "Phosphorylation of FRS2-beta by activated FGFR, Xenopus tropicalis"
xref: Reactome:REACT_114569 "Phosphorylation of ITIM in SIRP alpha, Bos taurus"
xref: Reactome:REACT_114600 "Binding and activation of MAP Kinase, Dictyostelium discoideum"
xref: Reactome:REACT_114640 "Phosphorylation of APS, Taeniopygia guttata"
xref: Reactome:REACT_114674 "Autophosphorylation of KIT, Bos taurus"
xref: Reactome:REACT_114702 "Autocatalytic phosphorylation of FGFR3b, Caenorhabditis elegans"
xref: Reactome:REACT_114781 "Binding and activation of MAP Kinase, Arabidopsis thaliana"
xref: Reactome:REACT_114786 "Autophosphorylation of KIT, Danio rerio"
xref: Reactome:REACT_114856 "Phosphorylation of FRS2-beta by activated FGFR, Danio rerio"
xref: Reactome:REACT_114870 "Phosphorylation of FRS2-beta by activated FGFR, Rattus norvegicus"
xref: Reactome:REACT_114895 "Activation of SRC by RAL-GTP, Drosophila melanogaster"
xref: Reactome:REACT_114914 "Phosphorylation of FRS2-beta by activated FGFR, Mus musculus"
xref: Reactome:REACT_114996 "Autophosphorylation of NCAM1 bound Fyn, Drosophila melanogaster"
xref: Reactome:REACT_114997 "Phosphorylation and activation of VAV1, Sus scrofa"
xref: Reactome:REACT_115017 "Phosphorylation of FRS2-beta by activated FGFR, Taeniopygia guttata"
xref: Reactome:REACT_115067 "Autocatalytic phosphorylation of FGFR2c, Caenorhabditis elegans"
xref: Reactome:REACT_115068 "Phosphorylation of ITIM in SIRP alpha, Gallus gallus"
xref: Reactome:REACT_115305 "Phosphorylation of DCC by Fyn, Gallus gallus"
xref: Reactome:REACT_115354 "Phosphorylation of FRS2-beta by activated FGFR, Bos taurus"
xref: Reactome:REACT_115375 "Autocatalytic phosphorylation of FGFR1b, Drosophila melanogaster"
xref: Reactome:REACT_115402 "Phosphorylation of FRS2-beta by activated FGFR, Sus scrofa"
xref: Reactome:REACT_115418 "Autocatalytic phosphorylation of FGFR2b, Drosophila melanogaster"
xref: Reactome:REACT_115469 "Autophosphorylation of SRC, Drosophila melanogaster"
xref: Reactome:REACT_115514 "Phosphorylation of Unc5C, Caenorhabditis elegans"
xref: Reactome:REACT_115610 "Trans-autophosphorylation of EGFRvIII mutant dimers, Homo sapiens"
xref: Reactome:REACT_115627 "Phosphorylation of PLC-gamma 1 by p-EGFR mutants, Homo sapiens"
xref: Reactome:REACT_115659 "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers, Homo sapiens"
xref: Reactome:REACT_115772 "Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers, Homo sapiens"
xref: Reactome:REACT_115779 "Plcg1 phosphorylation by P-ERBB2:P-EGFR, Homo sapiens"
xref: Reactome:REACT_115796 "Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants, Homo sapiens"
xref: Reactome:REACT_115797 "SRC family kinases phosphorylate ERBB2, Homo sapiens"
xref: Reactome:REACT_115817 "Activation of Src by Ral, Rattus norvegicus"
xref: Reactome:REACT_115841 "Phosphorylation of SHC1 by p-EGFR mutants, Homo sapiens"
xref: Reactome:REACT_115849 "Binding and activation of MAP kinase, Rattus norvegicus"
xref: Reactome:REACT_115850 "SHC1 phosphorylation by ERBB2 heterodimers, Homo sapiens"
xref: Reactome:REACT_115882 "PLCG1 phosphorylation by p-EGFR:p-ERBB2, Homo sapiens"
xref: Reactome:REACT_115935 "Phosphorylation of SHC1 by ERBB4 homodimers, Homo sapiens"
xref: Reactome:REACT_115938 "PRLR-bound STAT5 is phosphorylated, Homo sapiens"
xref: Reactome:REACT_115989 "Trans-autophosphorylation of ERBB4 homodimers, Homo sapiens"
xref: Reactome:REACT_116044 "Trans-autophosphorylation of ERBB2 heterodimers, Homo sapiens"
xref: Reactome:REACT_118103 "Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers, Gallus gallus"
xref: Reactome:REACT_118164 "Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers, Mus musculus"
xref: Reactome:REACT_118258 "Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers, Xenopus tropicalis"
xref: Reactome:REACT_118273 "Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers, Rattus norvegicus"
xref: Reactome:REACT_118292 "Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers, Taeniopygia guttata"
xref: Reactome:REACT_118395 "Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers, Caenorhabditis elegans"
xref: Reactome:REACT_118443 "Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers, Danio rerio"
xref: Reactome:REACT_118455 "Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers, Canis familiaris"
xref: Reactome:REACT_118461 "Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers, Bos taurus"
xref: Reactome:REACT_12016 "Binding and activation of MAP Kinase, Homo sapiens"
xref: Reactome:REACT_12030 "Activation of SRC by RAL-GTP, Homo sapiens"
xref: Reactome:REACT_12394 "Activation of ZAP-70, Homo sapiens"
xref: Reactome:REACT_12408 "Phoshorylation of PECAM-1 by Fyn or Lyn or c-Src, Homo sapiens"
xref: Reactome:REACT_12421 "Phosphorylation of TBSMs in LAT, Homo sapiens"
xref: Reactome:REACT_12424 "Phosphorylation of CBL (EGFR:CBL), Homo sapiens"
xref: Reactome:REACT_12467 "Activation of Lck, Homo sapiens"
xref: Reactome:REACT_12490 "Gab1 phosphorylation by EGFR kinase, Homo sapiens"
xref: Reactome:REACT_12491 "Phosphorylation of CBL (EGFR:GRB2:CBL), Homo sapiens"
xref: Reactome:REACT_12496 "Trans-phosphorylation of Tie2, Homo sapiens"
xref: Reactome:REACT_12498 "Phosphorylation of PLC-gamma1, Homo sapiens"
xref: Reactome:REACT_12538 "Phosphorylation of ZAP-70 by Lck, Homo sapiens"
xref: Reactome:REACT_12566 "Change of PKC theta conformation, Homo sapiens"
xref: Reactome:REACT_12569 "EGFR activates PLC-gamma1 by phosphorylation, Homo sapiens"
xref: Reactome:REACT_12615 "Phosphorylation of SLP-76, Homo sapiens"
xref: Reactome:REACT_12633 "Phosphorylation of ITAM motifs in CD3 complexes, Homo sapiens"
xref: Reactome:REACT_12640 "Inactivation of Lck by Csk, Homo sapiens"
xref: Reactome:REACT_13640 "Trans-phosphorylation of Tie2, Mus musculus"
xref: Reactome:REACT_13767 "Akt phosphorylates Foxo1 in the presence of IRS2, Mus musculus"
xref: Reactome:REACT_15545 "Autophosphorylation of SRC, Homo sapiens"
xref: Reactome:REACT_16926 "Autophosphorylation of PDGF beta receptors, Homo sapiens"
xref: Reactome:REACT_16991 "Activation of Src, Homo sapiens"
xref: Reactome:REACT_16993 "Autophosphorylation of PDGF alpha receptors, Homo sapiens"
xref: Reactome:REACT_17034 "Autophosphorylation of PDGF alpha/beta receptors, Homo sapiens"
xref: Reactome:REACT_18301 "Recruitment of FAK to NCAM1:Fyn in lipid rafts, Mus musculus"
xref: Reactome:REACT_18333 "Recruitment of FAK to NCAM1:Fyn in lipid rafts, Homo sapiens"
xref: Reactome:REACT_18343 "Autophosphorylation of NCAM1 bound Fyn, Homo sapiens"
xref: Reactome:REACT_18385 "Phosphorylation of FAK by Src kinase, Homo sapiens"
xref: Reactome:REACT_18394 "Phosphorylation of FAK by Src kinases, Mus musculus"
xref: Reactome:REACT_18408 "Autophosphorylation of NCAM1 bound Fyn, Mus musculus"
xref: Reactome:REACT_191 "Fyn/Lyn-mediated phosphorylation of FcR1 gamma, Homo sapiens"
xref: Reactome:REACT_19161 "Tyrosine phosphorylation of CRMPs by Fes, Homo sapiens"
xref: Reactome:REACT_19227 "Phosphorylation of Rob1 by Abl kinase, Homo sapiens"
xref: Reactome:REACT_19264 "Phosphorylation of CD28, Homo sapiens"
xref: Reactome:REACT_19316 "Activation of Vav1, Homo sapiens"
xref: Reactome:REACT_19380 "Phosphorylation of CTLA-4, Homo sapiens"
xref: Reactome:REACT_19381 "SEMA4D interacts with Plexin-B1:ErbB2, Homo sapiens"
xref: Reactome:REACT_19393 "Recruitment and activation of Cdk5, Homo sapiens"
xref: Reactome:REACT_19398 "SEMA4D interacts with Plexin-B1:Met, Homo sapiens"
xref: Reactome:REACT_19420 "Phosphorylation of Plexin-A, Homo sapiens"
xref: Reactome:REACT_21307 "Phosphorylation of FRS2-alpha by activated FGFR, Homo sapiens"
xref: Reactome:REACT_21329 "PLC gamma phosphorylation by FGFR, Homo sapiens"
xref: Reactome:REACT_21372 "SHP2 is phosphorylated by activated FGFR, Homo sapiens"
xref: Reactome:REACT_22163 "Phosphorylation of Unc5C, Mus musculus"
xref: Reactome:REACT_22164 "Phosphorylation of FADK1, Homo sapiens"
xref: Reactome:REACT_22174 "Phosphorylation of Unc5C, Homo sapiens"
xref: Reactome:REACT_22193 "Phosphorylation of L1 by EPHB2, Homo sapiens"
xref: Reactome:REACT_22202 "Phosphorylation of Neurofascin, Homo sapiens"
xref: Reactome:REACT_22213 "Phosphorylation of DCC by Fyn, Homo sapiens"
xref: Reactome:REACT_22229 "Phosphorylation of Y1229 in L1, Homo sapiens"
xref: Reactome:REACT_22236 "Phosphorylation of VAV2, Homo sapiens"
xref: Reactome:REACT_22260 "Phosphorylation of Neurofascin, Rattus norvegicus"
xref: Reactome:REACT_22363 "Phosphorylation of L1 by EPHB2, Gallus gallus"
xref: Reactome:REACT_22408 "Phosphorylation of L1 by SRC, Homo sapiens"
xref: Reactome:REACT_23775 "SYK activation by SRC, Homo sapiens"
xref: Reactome:REACT_23803 "Syk/Lck phosphorylate LAT, Homo sapiens"
xref: Reactome:REACT_23842 "Activation of STAT5a/b by JAK2, Homo sapiens"
xref: Reactome:REACT_23845 "CBL is tyrosine phosphorylated, Homo sapiens"
xref: Reactome:REACT_23897 "Cbl is tyrosine phosphorylated, Rattus norvegicus"
xref: Reactome:REACT_23918 "FGR binds and phosphorylates ApoER2, Homo sapiens"
xref: Reactome:REACT_23920 "Phosphorylation of ITIM in SIRP alpha, Homo sapiens"
xref: Reactome:REACT_23929 "Phosphorylation of nephrin by the Src family kinase Fyn, Homo sapiens"
xref: Reactome:REACT_23953 "Tyrosine kinases phosphorylate the receptor, Homo sapiens"
xref: Reactome:REACT_23957 "Phosphorylation of ITIM in SIRP alpha, Mus musculus"
xref: Reactome:REACT_23971 "SHC1 bound to the common beta chain becomes tyrosine phosphorylated, Homo sapiens"
xref: Reactome:REACT_23997 "Phosphorylation of ITIM in SIRP alpha, Rattus norvegicus"
xref: Reactome:REACT_24928 "Transphosphorylation of JAK1, Homo sapiens"
xref: Reactome:REACT_24933 "Phosphorylation of IFNGR1 by JAK kinases, Homo sapiens"
xref: Reactome:REACT_24993 "Phoshorylation of STAT1 by JAK kinases, Homo sapiens"
xref: Reactome:REACT_25017 "Phosphorylation of STAT1, Homo sapiens"
xref: Reactome:REACT_25105 "Formation of p-STAT1 homodimer, Homo sapiens"
xref: Reactome:REACT_25139 "Phosphorylation of JAK2, Homo sapiens"
xref: Reactome:REACT_25291 "Phosphorylation of STAT2, Homo sapiens"
xref: Reactome:REACT_25383 "Phosphorylation of INFAR1 by TYK2, Homo sapiens"
xref: Reactome:REACT_25401 "Activation of JAK kinases, Homo sapiens"
xref: Reactome:REACT_27150 "SHC1 bound to IL2 receptor is phosphorylated, Homo sapiens"
xref: Reactome:REACT_27154 "Recruited STAT5 is phosphorylated, Homo sapiens"
xref: Reactome:REACT_27196 "JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB, Homo sapiens"
xref: Reactome:REACT_27233 "SYK is a substrate for JAK1, Homo sapiens"
xref: Reactome:REACT_27274 "Within the IL-2R complex JAK3 phosphorylates JAK1, Homo sapiens"
xref: Reactome:REACT_28061 "Activation of SRC by RAL-GTP, Canis familiaris"
xref: Reactome:REACT_28067 "SEMA4D interacts with Plexin-B1:Met, Gallus gallus"
xref: Reactome:REACT_28316 "Autocatalytic phosphorylation of FGFR2c, Taeniopygia guttata"
xref: Reactome:REACT_28323 "Phosphorylation of DCC by Fyn, Xenopus tropicalis"
xref: Reactome:REACT_28460 "Phosphorylation of PLC-gamma1, Gallus gallus"
xref: Reactome:REACT_28552 "Phosphorylation of FAK by Src kinase, Danio rerio"
xref: Reactome:REACT_28638 "Recruitment of FAK to NCAM1:Fyn in lipid rafts, Bos taurus"
xref: Reactome:REACT_28674 "Autocatalytic phosphorylation of FGFR3b, Rattus norvegicus"
xref: Reactome:REACT_28866 "Autophosphorylation of SRC, Mus musculus"
xref: Reactome:REACT_29048 "Recruitment and activation of Cdk5, Bos taurus"
xref: Reactome:REACT_29099 "Phosphorylation of Rob1 by Abl kinase, Mus musculus"
xref: Reactome:REACT_29101 "Autophosphorylation of PDGF alpha receptors, Rattus norvegicus"
xref: Reactome:REACT_29123 "Phosphorylation of CBL (EGFR:GRB2:CBL), Bos taurus"
xref: Reactome:REACT_29148 "Phosphorylation of PLC-gamma1, Taeniopygia guttata"
xref: Reactome:REACT_29377 "Phosphorylation of ZAP-70 by Lck, Rattus norvegicus"
xref: Reactome:REACT_29521 "Phosphorylation of FAK by Src kinase, Sus scrofa"
xref: Reactome:REACT_29526 "SEMA4D interacts with Plexin-B1:Met, Danio rerio"
xref: Reactome:REACT_29577 "SEMA4D interacts with Plexin-B1:Met, Taeniopygia guttata"
xref: Reactome:REACT_29615 "Autophosphorylation of PDGF alpha/beta receptors, Taeniopygia guttata"
xref: Reactome:REACT_29693 "Phosphorylation of Plexin-A, Rattus norvegicus"
xref: Reactome:REACT_29769 "Autocatalytic phosphorylation of FGFR1c, Danio rerio"
xref: Reactome:REACT_29899 "Autocatalytic phosphorylation of FGFR1c, Taeniopygia guttata"
xref: Reactome:REACT_29922 "Autophosphorylation of NCAM1 bound Fyn, Sus scrofa"
xref: Reactome:REACT_30299 "Phosphorylation of FAK by Src kinase, Xenopus tropicalis"
xref: Reactome:REACT_30341 "PLC gamma phosphorylation by FGFR, Bos taurus"
xref: Reactome:REACT_30537 "Activation of Lck, Rattus norvegicus"
xref: Reactome:REACT_31235 "Phosphorylation of Plexin-A, Sus scrofa"
xref: Reactome:REACT_31355 "Phosphorylation of PLC-gamma1, Sus scrofa"
xref: Reactome:REACT_31634 "Phosphorylation of CBL (EGFR:GRB2:CBL), Danio rerio"
xref: Reactome:REACT_31682 "Autocatalytic phosphorylation of FGFR1b, Taeniopygia guttata"
xref: Reactome:REACT_31711 "Recruitment and activation of Cdk5, Xenopus tropicalis"
xref: Reactome:REACT_31830 "Recruitment of FAK to NCAM1:Fyn in lipid rafts, Rattus norvegicus"
xref: Reactome:REACT_32057 "EGFR activates PLC-gamma1 by phosphorylation, Danio rerio"
xref: Reactome:REACT_32137 "Phosphorylation of CD28, Gallus gallus"
xref: Reactome:REACT_32194 "Binding and activation of MAP Kinase, Bos taurus"
xref: Reactome:REACT_32216 "Phosphorylation of CD28, Taeniopygia guttata"
xref: Reactome:REACT_32277 "Phosphorylation of CD28, Sus scrofa"
xref: Reactome:REACT_32339 "Autophosphorylation of SRC, Sus scrofa"
xref: Reactome:REACT_32399 "Activation of SRC by RAL-GTP, Xenopus tropicalis"
xref: Reactome:REACT_32628 "Phosphorylation of FAK by Src kinase, Rattus norvegicus"
xref: Reactome:REACT_32736 "SHP2 is phosphorylated by activated FGFR, Sus scrofa"
xref: Reactome:REACT_33054 "SEMA4D interacts with Plexin-B1:ErbB2, Rattus norvegicus"
xref: Reactome:REACT_33087 "Autocatalytic phosphorylation of FGFR1c, Canis familiaris"
xref: Reactome:REACT_33105 "Autophosphorylation of PDGF alpha/beta receptors, Gallus gallus"
xref: Reactome:REACT_33138 "Autocatalytic phosphorylation of FGFR2c, Bos taurus"
xref: Reactome:REACT_33216 "Autocatalytic phosphorylation of FGFR2c, Gallus gallus"
xref: Reactome:REACT_33253 "Activation of Vav1, Rattus norvegicus"
xref: Reactome:REACT_33271 "Activation of Vav1, Gallus gallus"
xref: Reactome:REACT_33290 "Activation of SRC by RAL-GTP, Gallus gallus"
xref: Reactome:REACT_33346 "Autophosphorylation of SRC, Rattus norvegicus"
xref: Reactome:REACT_33756 "PLC gamma phosphorylation by FGFR, Danio rerio"
xref: Reactome:REACT_33914 "Phosphorylation of L1 by SRC, Mus musculus"
xref: Reactome:REACT_33926 "Phosphorylation of FADK1, Canis familiaris"
xref: Reactome:REACT_33942 "Activation of Src, Bos taurus"
xref: Reactome:REACT_34221 "FGR binds and phosphorylates ApoER2, Bos taurus"
xref: Reactome:REACT_34603 "FGR binds and phosphorylates ApoER2, Taeniopygia guttata"
xref: Reactome:REACT_34631 "Phosphorylation of CBL (EGFR:CBL), Mus musculus"
xref: Reactome:REACT_34748 "Phosphorylation of FAK by Src kinase, Taeniopygia guttata"
xref: Reactome:REACT_34775 "EGFR activates PLC-gamma1 by phosphorylation, Taeniopygia guttata"
xref: Reactome:REACT_38154 "Autocatalytic phosphorylation of FGFR2c, Canis familiaris"
xref: Reactome:REACT_40535 "Phosphorylation of CD28, Rattus norvegicus"
xref: Reactome:REACT_43352 "Autophosphorylation of PDGF beta receptors, Canis familiaris"
xref: Reactome:REACT_49563 "Phosphorylation of Rob1 by Abl kinase, Rattus norvegicus"
xref: Reactome:REACT_525 "Stabilisation of RAF by further phosphorylation, Homo sapiens"
xref: Reactome:REACT_57922 "Recruitment and activation of Cdk5, Rattus norvegicus"
xref: Reactome:REACT_60196 "Tyrosine phosphorylation of CRMPs by Fes, Gallus gallus"
xref: Reactome:REACT_6329 "Chico is phosphorylated, Drosophila melanogaster"
xref: Reactome:REACT_74834 "Autocatalytic phosphorylation of FGFR2b, Canis familiaris"
xref: Reactome:REACT_77018 "Phosphorylation of Unc5C, Canis familiaris"
xref: Reactome:REACT_77187 "Phosphorylation of CBL (EGFR:GRB2:CBL), Rattus norvegicus"
xref: Reactome:REACT_77310 "Phosphorylation of FAK by Src kinase, Gallus gallus"
xref: Reactome:REACT_77327 "Autocatalytic phosphorylation of FGFR2b, Rattus norvegicus"
xref: Reactome:REACT_77390 "Autocatalytic phosphorylation of FGFR3b, Mus musculus"
xref: Reactome:REACT_77515 "Recruitment and activation of Cdk5, Danio rerio"
xref: Reactome:REACT_77685 "Phosphorylation of TBSMs in LAT, Mus musculus"
xref: Reactome:REACT_77703 "FGR binds and phosphorylates ApoER2, Sus scrofa"
xref: Reactome:REACT_77767 "Phosphorylation of SLP-76, Mus musculus"
xref: Reactome:REACT_77899 "SEMA4D interacts with Plexin-B1:Met, Bos taurus"
xref: Reactome:REACT_78031 "Autocatalytic phosphorylation of FGFR3b, Drosophila melanogaster"
xref: Reactome:REACT_78203 "EGFR autophosphorylation, Canis familiaris"
xref: Reactome:REACT_78352 "PLC gamma phosphorylation by FGFR, Mus musculus"
xref: Reactome:REACT_78358 "SEMA4D interacts with Plexin-B1:Met, Rattus norvegicus"
xref: Reactome:REACT_78386 "Autocatalytic phosphorylation of Klotho-bound FGFR1c, Bos taurus"
xref: Reactome:REACT_78434 "Autocatalytic phosphorylation of FGFR3c, Sus scrofa"
xref: Reactome:REACT_78498 "Phosphorylation of L1 by EPHB2, Sus scrofa"
xref: Reactome:REACT_78685 "Autocatalytic phosphorylation of FGFR4, Rattus norvegicus"
xref: Reactome:REACT_78701 "Fyn/Lyn-mediated phosphorylation of FcR1 gamma, Rattus norvegicus"
xref: Reactome:REACT_78868 "Binding and activation of MAP Kinase, Mus musculus"
xref: Reactome:REACT_78902 "Binding and activation of MAP Kinase, Taeniopygia guttata"
xref: Reactome:REACT_78920 "Autophosphorylation of PDGF alpha/beta receptors, Danio rerio"
xref: Reactome:REACT_78933 "Phosphorylation of L1 by EPHB2, Bos taurus"
xref: Reactome:REACT_79167 "Autocatalytic phosphorylation of FGFR1c, Rattus norvegicus"
xref: Reactome:REACT_79338 "Recruitment of FAK to NCAM1:Fyn in lipid rafts, Gallus gallus"
xref: Reactome:REACT_79355 "SYK activation by SRC, Sus scrofa"
xref: Reactome:REACT_79394 "Autocatalytic phosphorylation of FGFR2c, Danio rerio"
xref: Reactome:REACT_79407 "SEMA4D interacts with Plexin-B1:ErbB2, Gallus gallus"
xref: Reactome:REACT_79427 "Binding and activation of MAP Kinase, Canis familiaris"
xref: Reactome:REACT_79501 "Inactivation of Lck by Csk, Mus musculus"
xref: Reactome:REACT_79608 "Autocatalytic phosphorylation of FGFR3c, Drosophila melanogaster"
xref: Reactome:REACT_79726 "Phosphorylation of CTLA-4, Taeniopygia guttata"
xref: Reactome:REACT_79900 "Activation of Vav1, Taeniopygia guttata"
xref: Reactome:REACT_79967 "Phosphorylation of L1 by EPHB2, Rattus norvegicus"
xref: Reactome:REACT_80076 "Phosphorylation of Plexin-A, Gallus gallus"
xref: Reactome:REACT_80306 "Phosphorylation of PLC-gamma1, Danio rerio"
xref: Reactome:REACT_80363 "Autocatalytic phosphorylation of FGFR1b, Mus musculus"
xref: Reactome:REACT_80527 "Phosphorylation of ITIM in SIRP alpha, Canis familiaris"
xref: Reactome:REACT_80528 "Autocatalytic phosphorylation of FGFR1c, Bos taurus"
xref: Reactome:REACT_80684 "Activation of Vav1, Sus scrofa"
xref: Reactome:REACT_80829 "EGFR autophosphorylation, Danio rerio"
xref: Reactome:REACT_81084 "Autophosphorylation of PDGF beta receptors, Danio rerio"
xref: Reactome:REACT_81125 "Tyrosine phosphorylation of CRMPs by Fes, Mus musculus"
xref: Reactome:REACT_81165 "Tyrosine phosphorylation of CRMPs by Fes, Danio rerio"
xref: Reactome:REACT_81176 "FGR binds and phosphorylates ApoER2, Mus musculus"
xref: Reactome:REACT_81177 "Autophosphorylation of PDGF alpha receptors, Xenopus tropicalis"
xref: Reactome:REACT_81361 "SYK activation by SRC, Taeniopygia guttata"
xref: Reactome:REACT_81398 "Activation of Src, Xenopus tropicalis"
xref: Reactome:REACT_81445 "Autocatalytic phosphorylation of FGFR1c, Xenopus tropicalis"
xref: Reactome:REACT_81546 "Phosphorylation of ITAM motifs in CD3 complexes, Rattus norvegicus"
xref: Reactome:REACT_81596 "Phosphorylation of Unc5C, Rattus norvegicus"
xref: Reactome:REACT_81637 "Phosphorylation of DCC by Fyn, Danio rerio"
xref: Reactome:REACT_81739 "Gab1 phosphorylation by EGFR kinase, Rattus norvegicus"
xref: Reactome:REACT_81818 "Phosphorylation of L1 by SRC, Rattus norvegicus"
xref: Reactome:REACT_81894 "Autocatalytic phosphorylation of Klotho-bound FGFR1c, Taeniopygia guttata"
xref: Reactome:REACT_82030 "Autocatalytic phosphorylation of FGFR3b, Xenopus tropicalis"
xref: Reactome:REACT_82127 "SEMA4D interacts with Plexin-B1:ErbB2, Danio rerio"
xref: Reactome:REACT_82339 "Phosphorylation of Unc5C, Xenopus tropicalis"
xref: Reactome:REACT_82460 "Trans-phosphorylation of Tie2, Gallus gallus"
xref: Reactome:REACT_82503 "EGFR autophosphorylation, Rattus norvegicus"
xref: Reactome:REACT_82597 "Phosphorylation of CBL (EGFR:GRB2:CBL), Xenopus tropicalis"
xref: Reactome:REACT_82628 "Autophosphorylation of PDGF alpha receptors, Bos taurus"
xref: Reactome:REACT_82799 "Tyrosine phosphorylation of CRMPs by Fes, Canis familiaris"
xref: Reactome:REACT_82806 "Autocatalytic phosphorylation of FGFR4, Taeniopygia guttata"
xref: Reactome:REACT_83131 "Activation of ZAP-70, Rattus norvegicus"
xref: Reactome:REACT_83348 "Activation of SRC by RAL-GTP, Mus musculus"
xref: Reactome:REACT_83486 "Binding and activation of MAP Kinase, Drosophila melanogaster"
xref: Reactome:REACT_83804 "Phosphorylation of FRS2-alpha by activated FGFR, Sus scrofa"
xref: Reactome:REACT_83974 "Autophosphorylation of NCAM1 bound Fyn, Canis familiaris"
xref: Reactome:REACT_84259 "Phosphorylation of EGFR by SRC kinase, Rattus norvegicus"
xref: Reactome:REACT_84420 "SEMA4D interacts with Plexin-B1:Met, Xenopus tropicalis"
xref: Reactome:REACT_84487 "Gab1 phosphorylation by EGFR kinase, Xenopus tropicalis"
xref: Reactome:REACT_84530 "SEMA4D interacts with Plexin-B1:Met, Sus scrofa"
xref: Reactome:REACT_84612 "Phosphorylation of Plexin-A, Canis familiaris"
xref: Reactome:REACT_84708 "EGFR activates PLC-gamma1 by phosphorylation, Canis familiaris"
xref: Reactome:REACT_84773 "Binding and activation of MAP Kinase, Danio rerio"
xref: Reactome:REACT_84824 "Phosphorylation of CBL (EGFR:GRB2:CBL), Gallus gallus"
xref: Reactome:REACT_84886 "Phosphorylation of CD28, Canis familiaris"
xref: Reactome:REACT_84961 "Phosphorylation of Unc5C, Sus scrofa"
xref: Reactome:REACT_84986 "Activation of Vav1, Canis familiaris"
xref: Reactome:REACT_85005 "Phosphorylation of DCC by Fyn, Sus scrofa"
xref: Reactome:REACT_85077 "Trans-phosphorylation of Tie2, Bos taurus"
xref: Reactome:REACT_85117 "Autocatalytic phosphorylation of FGFR4, Danio rerio"
xref: Reactome:REACT_85126 "Activation of Src, Mus musculus"
xref: Reactome:REACT_85374 "Autocatalytic phosphorylation of FGFR3c, Taeniopygia guttata"
xref: Reactome:REACT_85443 "Phosphorylation of CBL (EGFR:GRB2:CBL), Taeniopygia guttata"
xref: Reactome:REACT_85500 "Tyrosine phosphorylation of CRMPs by Fes, Taeniopygia guttata"
xref: Reactome:REACT_85722 "Syk/Lck phosphorylate LAT, Sus scrofa"
xref: Reactome:REACT_85785 "Phosphorylation of Rob1 by Abl kinase, Taeniopygia guttata"
xref: Reactome:REACT_85969 "Gab1 phosphorylation by EGFR kinase, Canis familiaris"
xref: Reactome:REACT_86238 "Recruitment of FAK to NCAM1:Fyn in lipid rafts, Taeniopygia guttata"
xref: Reactome:REACT_86388 "Phosphorylation of nephrin by the Src family kinase Fyn, Canis familiaris"
xref: Reactome:REACT_86407 "Recruitment of FAK to NCAM1:Fyn in lipid rafts, Canis familiaris"
xref: Reactome:REACT_86502 "Autophosphorylation of PDGF alpha/beta receptors, Canis familiaris"
xref: Reactome:REACT_86510 "Phosphorylation of CBL (EGFR:CBL), Canis familiaris"
xref: Reactome:REACT_86579 "Autocatalytic phosphorylation of FGFR2b, Taeniopygia guttata"
xref: Reactome:REACT_86618 "EGFR autophosphorylation, Xenopus tropicalis"
xref: Reactome:REACT_86622 "Phosphorylation of PLC-gamma1, Rattus norvegicus"
xref: Reactome:REACT_86769 "PLC gamma phosphorylation by FGFR, Gallus gallus"
xref: Reactome:REACT_86814 "Activation of Src, Rattus norvegicus"
xref: Reactome:REACT_87052 "Autophosphorylation of NCAM1 bound Fyn, Bos taurus"
xref: Reactome:REACT_87153 "Autophosphorylation of PDGF beta receptors, Taeniopygia guttata"
xref: Reactome:REACT_87252 "Autophosphorylation of PDGF beta receptors, Gallus gallus"
xref: Reactome:REACT_87259 "Autocatalytic phosphorylation of FGFR1c, Drosophila melanogaster"
xref: Reactome:REACT_87371 "Phosphorylation of L1 by SRC, Sus scrofa"
xref: Reactome:REACT_87435 "Phosphorylation of EGFR by SRC kinase, Canis familiaris"
xref: Reactome:REACT_87511 "Fyn/Lyn-mediated phosphorylation of FcR1 gamma, Mus musculus"
xref: Reactome:REACT_87566 "Autocatalytic phosphorylation of FGFR3c, Danio rerio"
xref: Reactome:REACT_87684 "Autocatalytic phosphorylation of FGFR3c, Mus musculus"
xref: Reactome:REACT_87815 "Phosphorylation of Rob1 by Abl kinase, Gallus gallus"
xref: Reactome:REACT_87823 "SHP2 is phosphorylated by activated FGFR, Danio rerio"
xref: Reactome:REACT_87830 "SEMA4D interacts with Plexin-B1:ErbB2, Sus scrofa"
xref: Reactome:REACT_87952 "Phosphorylation of Rob1 by Abl kinase, Danio rerio"
xref: Reactome:REACT_87984 "Autophosphorylation of PDGF alpha/beta receptors, Bos taurus"
xref: Reactome:REACT_88004 "Phosphorylation of EGFR by SRC kinase, Gallus gallus"
xref: Reactome:REACT_88019 "Autophosphorylation of PDGF beta receptors, Bos taurus"
xref: Reactome:REACT_88033 "Trans-phosphorylation of Tie2, Xenopus tropicalis"
xref: Reactome:REACT_88054 "PLC gamma phosphorylation by FGFR, Canis familiaris"
xref: Reactome:REACT_88160 "Autophosphorylation of SRC, Danio rerio"
xref: Reactome:REACT_88281 "Autophosphorylation of PDGF alpha receptors, Taeniopygia guttata"
xref: Reactome:REACT_88379 "Phosphorylation of nephrin by the Src family kinase Fyn, Danio rerio"
xref: Reactome:REACT_88380 "Phosphorylation of FRS2-alpha by activated FGFR, Taeniopygia guttata"
xref: Reactome:REACT_88407 "Autocatalytic phosphorylation of FGFR2c, Sus scrofa"
xref: Reactome:REACT_88554 "Autocatalytic phosphorylation of FGFR1b, Gallus gallus"
xref: Reactome:REACT_88600 "EGFR activates PLC-gamma1 by phosphorylation, Rattus norvegicus"
xref: Reactome:REACT_89014 "SYK activation by SRC, Gallus gallus"
xref: Reactome:REACT_89147 "Autocatalytic phosphorylation of FGFR3c, Gallus gallus"
xref: Reactome:REACT_89172 "SHP2 is phosphorylated by activated FGFR, Mus musculus"
xref: Reactome:REACT_89228 "SHP2 is phosphorylated by activated FGFR, Canis familiaris"
xref: Reactome:REACT_89287 "Gab1 phosphorylation by EGFR kinase, Mus musculus"
xref: Reactome:REACT_89340 "Phosphorylation of FADK1, Danio rerio"
xref: Reactome:REACT_89450 "Phosphorylation of FRS2-alpha by activated FGFR, Gallus gallus"
xref: Reactome:REACT_89463 "Gab1 phosphorylation by EGFR kinase, Bos taurus"
xref: Reactome:REACT_89473 "Autophosphorylation of PDGF beta receptors, Mus musculus"
xref: Reactome:REACT_89616 "Autocatalytic phosphorylation of Klotho-bound FGFR1c, Sus scrofa"
xref: Reactome:REACT_89754 "Activation of Src, Sus scrofa"
xref: Reactome:REACT_89762 "Phosphorylation of CBL (EGFR:GRB2:CBL), Canis familiaris"
xref: Reactome:REACT_90297 "Gab1 phosphorylation by EGFR kinase, Danio rerio"
xref: Reactome:REACT_90301 "SEMA4D interacts with Plexin-B1:ErbB2, Bos taurus"
xref: Reactome:REACT_90417 "Autocatalytic phosphorylation of FGFR2c, Drosophila melanogaster"
xref: Reactome:REACT_90496 "Phosphorylation of L1 by SRC, Danio rerio"
xref: Reactome:REACT_90538 "Change of PKC theta conformation, Rattus norvegicus"
xref: Reactome:REACT_90572 "Phosphorylation of Unc5C, Danio rerio"
xref: Reactome:REACT_90657 "Phosphorylation of L1 by EPHB2, Danio rerio"
xref: Reactome:REACT_91164 "Autocatalytic phosphorylation of Klotho-bound FGFR1c, Mus musculus"
xref: Reactome:REACT_91188 "Recruitment of FAK to NCAM1:Fyn in lipid rafts, Sus scrofa"
xref: Reactome:REACT_91376 "Activation of Src, Gallus gallus"
xref: Reactome:REACT_91467 "Autophosphorylation of NCAM1 bound Fyn, Rattus norvegicus"
xref: Reactome:REACT_91515 "Phosphorylation of FADK1, Drosophila melanogaster"
xref: Reactome:REACT_91538 "Fyn/Lyn-mediated phosphorylation of FcR1 gamma, Sus scrofa"
xref: Reactome:REACT_91883 "Autocatalytic phosphorylation of FGFR3b, Canis familiaris"
xref: Reactome:REACT_91997 "SYK activation by SRC, Rattus norvegicus"
xref: Reactome:REACT_92220 "Syk/Lck phosphorylate LAT, Rattus norvegicus"
xref: Reactome:REACT_92230 "Phosphorylation of EGFR by SRC kinase, Xenopus tropicalis"
xref: Reactome:REACT_92251 "Phosphorylation of L1 by SRC, Bos taurus"
xref: Reactome:REACT_92280 "Phosphorylation of EGFR by SRC kinase, Mus musculus"
xref: Reactome:REACT_92311 "Gab1 phosphorylation by EGFR kinase, Taeniopygia guttata"
xref: Reactome:REACT_92436 "Recruitment and activation of Cdk5, Mus musculus"
xref: Reactome:REACT_92703 "Phosphorylation of FAK by Src kinase, Canis familiaris"
xref: Reactome:REACT_92709 "Change of PKC theta conformation, Mus musculus"
xref: Reactome:REACT_92984 "Phosphorylation of FAK by Src kinase, Bos taurus"
xref: Reactome:REACT_93198 "Activation of Lck, Mus musculus"
xref: Reactome:REACT_93265 "PLC gamma phosphorylation by FGFR, Xenopus tropicalis"
xref: Reactome:REACT_93848 "Phosphorylation of Plexin-A, Danio rerio"
xref: Reactome:REACT_9388 "EGFR autophosphorylation, Homo sapiens"
xref: Reactome:REACT_9401 "Phosphorylation of EGFR by SRC kinase, Homo sapiens"
xref: Reactome:REACT_94058 "Phosphorylation of Unc5C, Bos taurus"
xref: Reactome:REACT_94134 "EGFR activates PLC-gamma1 by phosphorylation, Xenopus tropicalis"
xref: Reactome:REACT_94177 "Autocatalytic phosphorylation of FGFR3c, Rattus norvegicus"
xref: Reactome:REACT_9419 "Autocatalytic phosphorylation of FGFR3c, Homo sapiens"
xref: Reactome:REACT_94210 "Phosphorylation of Plexin-A, Bos taurus"
xref: Reactome:REACT_94240 "Autocatalytic phosphorylation of FGFR3b, Gallus gallus"
xref: Reactome:REACT_9432 "Autocatalytic phosphorylation of FGFR2c, Homo sapiens"
xref: Reactome:REACT_9433 "Autocatalytic phosphorylation of Klotho-bound FGFR1c, Homo sapiens"
xref: Reactome:REACT_94384 "Phosphorylation of CBL (EGFR:CBL), Danio rerio"
xref: Reactome:REACT_94446 "Phosphorylation of Rob1 by Abl kinase, Bos taurus"
xref: Reactome:REACT_94605 "Recruitment of FAK to NCAM1:Fyn in lipid rafts, Danio rerio"
xref: Reactome:REACT_9474 "Autocatalytic phosphorylation of FGFR4, Homo sapiens"
xref: Reactome:REACT_9476 "Autocatalytic phosphorylation of FGFR2b, Homo sapiens"
xref: Reactome:REACT_94802 "Autophosphorylation of SRC, Canis familiaris"
xref: Reactome:REACT_94886 "Phosphorylation of CD28, Mus musculus"
xref: Reactome:REACT_9493 "Autocatalytic phosphorylation of FGFR1b, Homo sapiens"
xref: Reactome:REACT_9498 "Autocatalytic phosphorylation of FGFR1c, Homo sapiens"
xref: Reactome:REACT_95037 "Phosphorylation of FADK1, Caenorhabditis elegans"
xref: Reactome:REACT_9519 "Autocatalytic phosphorylation of FGFR3b, Homo sapiens"
xref: Reactome:REACT_95415 "Autocatalytic phosphorylation of FGFR3b, Bos taurus"
xref: Reactome:REACT_95734 "Autocatalytic phosphorylation of FGFR3c, Bos taurus"
xref: Reactome:REACT_95742 "Phosphorylation of DCC by Fyn, Caenorhabditis elegans"
xref: Reactome:REACT_95822 "Phosphorylation of L1 by EPHB2, Canis familiaris"
xref: Reactome:REACT_95833 "SHP2 is phosphorylated by activated FGFR, Taeniopygia guttata"
xref: Reactome:REACT_95870 "Recruitment of FAK to NCAM1:Fyn in lipid rafts, Drosophila melanogaster"
xref: Reactome:REACT_95963 "Autocatalytic phosphorylation of FGFR2b, Xenopus tropicalis"
xref: Reactome:REACT_96010 "Autocatalytic phosphorylation of Klotho-bound FGFR1c, Canis familiaris"
xref: Reactome:REACT_96018 "Autophosphorylation of PDGF alpha receptors, Mus musculus"
xref: Reactome:REACT_96142 "Phosphorylation of FRS2-alpha by activated FGFR, Xenopus tropicalis"
xref: Reactome:REACT_96362 "Autophosphorylation of PDGF alpha/beta receptors, Mus musculus"
xref: Reactome:REACT_96502 "Autocatalytic phosphorylation of FGFR3b, Sus scrofa"
xref: Reactome:REACT_96514 "Autophosphorylation of PDGF alpha/beta receptors, Xenopus tropicalis"
xref: Reactome:REACT_96580 "Autocatalytic phosphorylation of FGFR4, Drosophila melanogaster"
xref: Reactome:REACT_96596 "Autocatalytic phosphorylation of Klotho-bound FGFR1c, Danio rerio"
xref: Reactome:REACT_96705 "Autocatalytic phosphorylation of Klotho-bound FGFR1c, Gallus gallus"
xref: Reactome:REACT_96733 "Trans-phosphorylation of Tie2, Rattus norvegicus"
xref: Reactome:REACT_97087 "Autocatalytic phosphorylation of FGFR3c, Canis familiaris"
xref: Reactome:REACT_97142 "Phosphorylation of DCC by Fyn, Canis familiaris"
xref: Reactome:REACT_97562 "Phosphorylation of CBL (EGFR:CBL), Rattus norvegicus"
xref: Reactome:REACT_97685 "Phosphorylation of Plexin-A, Xenopus tropicalis"
xref: Reactome:REACT_97728 "SYK activation by SRC, Mus musculus"
xref: Reactome:REACT_97810 "SEMA4D interacts with Plexin-B1:ErbB2, Taeniopygia guttata"
xref: Reactome:REACT_97895 "Binding and activation of MAP Kinase, Gallus gallus"
xref: Reactome:REACT_98106 "Recruitment and activation of Cdk5, Canis familiaris"
xref: Reactome:REACT_98221 "Phosphorylation of Rob1 by Abl kinase, Sus scrofa"
xref: Reactome:REACT_98541 "SEMA4D interacts with Plexin-B1:Met, Canis familiaris"
xref: Reactome:REACT_98748 "Activation of Vav1, Xenopus tropicalis"
xref: Reactome:REACT_98850 "Autophosphorylation of PDGF alpha/beta receptors, Sus scrofa"
xref: Reactome:REACT_98862 "Autocatalytic phosphorylation of FGFR3b, Danio rerio"
xref: Reactome:REACT_98867 "FGR binds and phosphorylates ApoER2, Rattus norvegicus"
xref: Reactome:REACT_98878 "Activation of Src, Taeniopygia guttata"
xref: Reactome:REACT_98980 "Phosphorylation of SLP-76, Rattus norvegicus"
xref: Reactome:REACT_98992 "Autocatalytic phosphorylation of FGFR4, Xenopus tropicalis"
xref: Reactome:REACT_99026 "Autocatalytic phosphorylation of FGFR2c, Xenopus tropicalis"
xref: Reactome:REACT_99257 "Autocatalytic phosphorylation of FGFR2b, Gallus gallus"
xref: Reactome:REACT_99293 "Syk/Lck phosphorylate LAT, Canis familiaris"
xref: Reactome:REACT_99500 "Activation of Src, Canis familiaris"
xref: Reactome:REACT_99541 "Fyn/Lyn-mediated phosphorylation of FcR1 gamma, Bos taurus"
xref: Reactome:REACT_99611 "Phosphorylation of FADK1, Rattus norvegicus"
xref: Reactome:REACT_99704 "SHP2 is phosphorylated by activated FGFR, Gallus gallus"
xref: Reactome:REACT_99827 "SYK activation by SRC, Danio rerio"
xref: Reactome:REACT_99888 "Gab1 phosphorylation by EGFR kinase, Gallus gallus"
is_a: GO:0004672 ! protein kinase activity
relationship: part_of GO:0018108 ! peptidyl-tyrosine phosphorylation

[Term]
id: GO:0004714
name: transmembrane receptor protein tyrosine kinase activity
namespace: molecular_function
def: "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah]
subset: gosubset_prok
synonym: "anaplastic lymphoma kinase activity" NARROW [EC:2.7.10.1]
synonym: "ATP:protein-L-tyrosine O-phosphotransferase (receptor-type) activity" EXACT [EC:2.7.10.1]
synonym: "ATP:protein-tyrosine O-phosphotransferase activity" BROAD [EC:2.7.10.1]
synonym: "Drosophila Eph kinase activity" NARROW [EC:2.7.10.1]
synonym: "ephrin-B3 receptor tyrosine kinase activity" NARROW [EC:2.7.10.1]
synonym: "insulin receptor protein-tyrosine kinase activity" NARROW [EC:2.7.10.1]
synonym: "neurite outgrowth regulating kinase activity" NARROW [EC:2.7.10.1]
synonym: "neurotrophin TRK receptor activity" RELATED []
synonym: "neurotrophin TRKA receptor activity" RELATED []
synonym: "neurotrophin TRKB receptor activity" RELATED []
synonym: "neurotrophin TRKC receptor activity" RELATED []
synonym: "novel oncogene with kinase-domain activity" NARROW [EC:2.7.10.1]
synonym: "receptor protein tyrosine kinase activity" EXACT [EC:2.7.10.1]
synonym: "receptor protein-tyrosine kinase activity" EXACT [EC:2.7.10.1]
synonym: "sevenless receptor activity" RELATED []
xref: EC:2.7.10.1
xref: MetaCyc:2.7.10.1-RXN
xref: Reactome:REACT_100729 "Phosphorylation of IRS, Danio rerio"
xref: Reactome:REACT_101059 "Phosphorylation of SHC, Canis familiaris"
xref: Reactome:REACT_103643 "ARMS is phosphorylated by active TrkA receptor, Mus musculus"
xref: Reactome:REACT_103872 "SHC, complexed with TrkA, is tyrosine-phosphorylated, Gallus gallus"
xref: Reactome:REACT_103996 "Phosphorylation of IRS, Xenopus tropicalis"
xref: Reactome:REACT_104778 "SHC1 phosphorylation by phosphorylated EGFR, Taeniopygia guttata"
xref: Reactome:REACT_105908 "Phosphorylation of SHC, Rattus norvegicus"
xref: Reactome:REACT_106761 "Autophosphorylation of insulin receptor, Gallus gallus"
xref: Reactome:REACT_106931 "Phosphorylation of IRS, Taeniopygia guttata"
xref: Reactome:REACT_106954 "TrkA receptor autophosphorylates, Xenopus tropicalis"
xref: Reactome:REACT_107278 "ARMS is phosphorylated by active TrkA receptor, Danio rerio"
xref: Reactome:REACT_107590 "TrkA phosphorylates PLCG1, Bos taurus"
xref: Reactome:REACT_107902 "SHC, complexed with TrkA, is tyrosine-phosphorylated, Mus musculus"
xref: Reactome:REACT_107918 "SHC1 phosphorylation by phosphorylated EGFR, Gallus gallus"
xref: Reactome:REACT_108158 "TrkA phosphorylates PLCG1, Gallus gallus"
xref: Reactome:REACT_109200 "TRKA phosphorylates IRS, Xenopus tropicalis"
xref: Reactome:REACT_109686 "Autophosphorylation of insulin receptor, Rattus norvegicus"
xref: Reactome:REACT_110882 "TRKA phosphorylates IRS, Gallus gallus"
xref: Reactome:REACT_115842 "Shc, complexed with TrkA, is Tyrosine-phosphorylated, Rattus norvegicus"
xref: Reactome:REACT_116042 "Active Trk phosphorylates PLCG1, Rattus norvegicus"
xref: Reactome:REACT_12003 "SHC, complexed with TrkA, is tyrosine-phosphorylated, Homo sapiens"
xref: Reactome:REACT_12059 "TrkA phosphorylates PLCG1, Homo sapiens"
xref: Reactome:REACT_12063 "FRS2 is phosphorylated by active TrkA receptor, Homo sapiens"
xref: Reactome:REACT_12066 "ARMS is phosphorylated by active TrkA receptor, Homo sapiens"
xref: Reactome:REACT_12434 "TRKA phosphorylates IRS, Homo sapiens"
xref: Reactome:REACT_12592 "SHC1 phosphorylation by phosphorylated EGFR, Homo sapiens"
xref: Reactome:REACT_2015 "Phosphorylation of SHC, Homo sapiens"
xref: Reactome:REACT_2211 "Autophosphorylation of insulin receptor, Homo sapiens"
xref: Reactome:REACT_28481 "Phosphorylation of SHC, Taeniopygia guttata"
xref: Reactome:REACT_29831 "Phosphorylation of IRS, Gallus gallus"
xref: Reactome:REACT_30918 "FRS2 is phosphorylated by active TrkA receptor, Rattus norvegicus"
xref: Reactome:REACT_30960 "FRS2 is phosphorylated by active TrkA receptor, Danio rerio"
xref: Reactome:REACT_31238 "FRS2 is phosphorylated by active TrkA receptor, Mus musculus"
xref: Reactome:REACT_31675 "Autophosphorylation of insulin receptor, Danio rerio"
xref: Reactome:REACT_31943 "ARMS is phosphorylated by active TrkA receptor, Bos taurus"
xref: Reactome:REACT_33793 "Autophosphorylation of insulin receptor, Xenopus tropicalis"
xref: Reactome:REACT_33826 "TrkA phosphorylates PLCG1, Sus scrofa"
xref: Reactome:REACT_33848 "TrkA phosphorylates PLCG1, Canis familiaris"
xref: Reactome:REACT_33897 "TRKA phosphorylates IRS, Bos taurus"
xref: Reactome:REACT_342 "Phosphorylation of IRS, Homo sapiens"
xref: Reactome:REACT_6189 "Autophosphorylation of DINR, Drosophila melanogaster"
xref: Reactome:REACT_77730 "ARMS is phosphorylated by active TrkA receptor, Taeniopygia guttata"
xref: Reactome:REACT_78649 "TRKA phosphorylates IRS, Canis familiaris"
xref: Reactome:REACT_78974 "Phosphorylation of IRS, Bos taurus"
xref: Reactome:REACT_79688 "SHC, complexed with TrkA, is tyrosine-phosphorylated, Xenopus tropicalis"
xref: Reactome:REACT_79822 "ARMS is phosphorylated by active TrkA receptor, Gallus gallus"
xref: Reactome:REACT_80568 "FRS2 is phosphorylated by active TrkA receptor, Bos taurus"
xref: Reactome:REACT_80933 "FRS2 is phosphorylated by active TrkA receptor, Sus scrofa"
xref: Reactome:REACT_82236 "Autophosphorylation of insulin receptor, Canis familiaris"
xref: Reactome:REACT_83172 "SHC, complexed with TrkA, is tyrosine-phosphorylated, Danio rerio"
xref: Reactome:REACT_83536 "TrkA receptor autophosphorylates, Mus musculus"
xref: Reactome:REACT_83584 "TRKA phosphorylates IRS, Danio rerio"
xref: Reactome:REACT_84472 "FRS2 is phosphorylated by active TrkA receptor, Xenopus tropicalis"
xref: Reactome:REACT_84554 "ARMS is phosphorylated by active TrkA receptor, Rattus norvegicus"
xref: Reactome:REACT_85483 "Phosphorylation of SHC, Bos taurus"
xref: Reactome:REACT_86023 "TrkA receptor autophosphorylates, Bos taurus"
xref: Reactome:REACT_86529 "TRKA phosphorylates IRS, Sus scrofa"
xref: Reactome:REACT_87015 "SHC1 phosphorylation by phosphorylated EGFR, Mus musculus"
xref: Reactome:REACT_87046 "FRS2 is phosphorylated by active TrkA receptor, Canis familiaris"
xref: Reactome:REACT_87673 "TRKA phosphorylates IRS, Rattus norvegicus"
xref: Reactome:REACT_87675 "Autophosphorylation of insulin receptor, Taeniopygia guttata"
xref: Reactome:REACT_87906 "SHC, complexed with TrkA, is tyrosine-phosphorylated, Canis familiaris"
xref: Reactome:REACT_88124 "FRS2 is phosphorylated by active TrkA receptor, Gallus gallus"
xref: Reactome:REACT_88945 "Phosphorylation of SHC, Gallus gallus"
xref: Reactome:REACT_89905 "TrkA phosphorylates PLCG1, Danio rerio"
xref: Reactome:REACT_90725 "TrkA phosphorylates PLCG1, Mus musculus"
xref: Reactome:REACT_91057 "SHC1 phosphorylation by phosphorylated EGFR, Xenopus tropicalis"
xref: Reactome:REACT_91150 "Phosphorylation of IRS, Canis familiaris"
xref: Reactome:REACT_91374 "SHC1 phosphorylation by phosphorylated EGFR, Canis familiaris"
xref: Reactome:REACT_91698 "Phosphorylation of SHC, Xenopus tropicalis"
xref: Reactome:REACT_92936 "TrkA receptor autophosphorylates, Danio rerio"
xref: Reactome:REACT_93004 "ARMS is phosphorylated by active TrkA receptor, Canis familiaris"
xref: Reactome:REACT_93045 "SHC1 phosphorylation by phosphorylated EGFR, Danio rerio"
xref: Reactome:REACT_94031 "Autophosphorylation of insulin receptor, Mus musculus"
xref: Reactome:REACT_94040 "Phosphorylation of SHC, Mus musculus"
xref: Reactome:REACT_94130 "TrkA receptor autophosphorylates, Canis familiaris"
xref: Reactome:REACT_94603 "Phosphorylation of IRS, Rattus norvegicus"
xref: Reactome:REACT_94880 "SHC, complexed with TrkA, is tyrosine-phosphorylated, Bos taurus"
xref: Reactome:REACT_94934 "Phosphorylation of SHC, Danio rerio"
xref: Reactome:REACT_95686 "SHC1 phosphorylation by phosphorylated EGFR, Rattus norvegicus"
xref: Reactome:REACT_96548 "ARMS is phosphorylated by active TrkA receptor, Xenopus tropicalis"
xref: Reactome:REACT_96894 "Phosphorylation of IRS, Mus musculus"
xref: Reactome:REACT_97074 "TrkA receptor autophosphorylates, Sus scrofa"
xref: Reactome:REACT_97123 "SHC, complexed with TrkA, is tyrosine-phosphorylated, Sus scrofa"
xref: Reactome:REACT_97498 "TrkA phosphorylates PLCG1, Xenopus tropicalis"
xref: Reactome:REACT_98041 "Autophosphorylation of insulin receptor, Bos taurus"
xref: Reactome:REACT_99216 "TrkA receptor autophosphorylates, Gallus gallus"
xref: Reactome:REACT_9962 "TrkA receptor autophosphorylates, Homo sapiens"
is_a: GO:0004713 ! protein tyrosine kinase activity
is_a: GO:0019199 ! transmembrane receptor protein kinase activity

[Term]
id: GO:0004715
name: non-membrane spanning protein tyrosine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2]
synonym: "ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" EXACT [EC:2.7.10.2]
synonym: "ATP:protein-tyrosine O-phosphotransferase activity" BROAD [EC:2.7.10.2]
synonym: "Bruton's tyrosine kinase activity" NARROW [EC:2.7.10.2]
synonym: "cytoplasmic protein tyrosine kinase activity" NARROW [EC:2.7.10.2]
synonym: "focal adhesion kinase activity" NARROW [EC:2.7.10.2]
synonym: "janus kinase 1 activity" NARROW [EC:2.7.10.2]
synonym: "janus kinase 2 activity" NARROW [EC:2.7.10.2]
synonym: "janus kinase 3 activity" NARROW [EC:2.7.10.2]
synonym: "non-specific protein-tyrosine kinase activity" EXACT [EC:2.7.10.2]
synonym: "p60c-src protein tyrosine kinase activity" NARROW [EC:2.7.10.2]
xref: EC:2.7.10.2
xref: MetaCyc:2.7.10.2-RXN
xref: Reactome:REACT_103590 "Syk phosphorylates Vav, Taeniopygia guttata"
xref: Reactome:REACT_106932 "Syk phosphorylates Vav, Xenopus tropicalis"
xref: Reactome:REACT_108585 "Syk phosphorylates Vav, Danio rerio"
xref: Reactome:REACT_110171 "Fgr may phosphorylate p38 MAPK, Xenopus tropicalis"
xref: Reactome:REACT_110576 "Fgr may phosphorylate p38 MAPK, Canis familiaris"
xref: Reactome:REACT_111142 "Jak2 phosphorylates Stat1/Stat3, Mus musculus"
xref: Reactome:REACT_111190 "JAK2 phosphorylation of IRS-1/2, Homo sapiens"
xref: Reactome:REACT_111207 "JAK2 phosphorylates STAT1/STAT3, Homo sapiens"
xref: Reactome:REACT_111211 "Stat5 tyrosine phosphorylation, Mus musculus"
xref: Reactome:REACT_111235 "Lyn activates ERK, Homo sapiens"
xref: Reactome:REACT_112025 "Fgr may phosphorylate p38 MAPK, Dictyostelium discoideum"
xref: Reactome:REACT_112421 "Fgr may phosphorylate p38 MAPK, Drosophila melanogaster"
xref: Reactome:REACT_112972 "Fgr may phosphorylate p38 MAPK, Oryza sativa"
xref: Reactome:REACT_113743 "Fgr may phosphorylate p38 MAPK, Arabidopsis thaliana"
xref: Reactome:REACT_115537 "IL7ra is phosphorylated on Y449, Mus musculus"
xref: Reactome:REACT_115681 "Shp2 is phosphorylated, Rattus norvegicus"
xref: Reactome:REACT_115719 "SHP2 is phosphorylated, Homo sapiens"
xref: Reactome:REACT_115749 "IL7RA is phosphorylated on Y449, Homo sapiens"
xref: Reactome:REACT_23793 "Syk phosphorylates Vav, Homo sapiens"
xref: Reactome:REACT_23800 "Syk autophosphorylates, Homo sapiens"
xref: Reactome:REACT_23935 "JAK2 is phosphorylated, activated, Homo sapiens"
xref: Reactome:REACT_23951 "Fgr may phosphorylate p38 MAPK, Homo sapiens"
xref: Reactome:REACT_24012 "Src phosphorylates Stat3, Mus musculus"
xref: Reactome:REACT_27185 "SHP2 is phosphorylated, Homo sapiens"
xref: Reactome:REACT_27203 "Tyrosine phosphorylation of STATs by IL6 receptor, Homo sapiens"
xref: Reactome:REACT_31703 "Fgr may phosphorylate p38 MAPK, Taeniopygia guttata"
xref: Reactome:REACT_80183 "Fgr may phosphorylate p38 MAPK, Mus musculus"
xref: Reactome:REACT_81668 "Syk phosphorylates Vav, Bos taurus"
xref: Reactome:REACT_81970 "Syk phosphorylates Vav, Canis familiaris"
xref: Reactome:REACT_83551 "Fgr may phosphorylate p38 MAPK, Sus scrofa"
xref: Reactome:REACT_83903 "Syk phosphorylates Vav, Rattus norvegicus"
xref: Reactome:REACT_88262 "Fgr may phosphorylate p38 MAPK, Rattus norvegicus"
xref: Reactome:REACT_91191 "Syk phosphorylates Vav, Mus musculus"
xref: Reactome:REACT_95454 "Syk phosphorylates Vav, Sus scrofa"
xref: Reactome:REACT_96572 "Fgr may phosphorylate p38 MAPK, Bos taurus"
xref: Reactome:REACT_98652 "Syk phosphorylates Vav, Gallus gallus"
is_a: GO:0004713 ! protein tyrosine kinase activity

[Term]
id: GO:0004716
name: receptor signaling protein tyrosine kinase activity
namespace: molecular_function
def: "Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.2]
synonym: "receptor signalling protein tyrosine kinase activity" EXACT []
xref: EC:2.7.10.-
is_a: GO:0004713 ! protein tyrosine kinase activity
is_a: GO:0005057 ! receptor signaling protein activity
relationship: part_of GO:0023014 ! signal transduction by protein phosphorylation

[Term]
id: GO:0004717
name: obsolete focal adhesion kinase activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jid]
comment: This term was made obsolete because it represents a gene product, and because the gene was named after its location of action rather than after its molecular function.
synonym: "FAK" EXACT []
synonym: "focal adhesion kinase activity" EXACT []
is_obsolete: true
replaced_by: GO:0004713

[Term]
id: GO:0004719
name: protein-L-isoaspartate (D-aspartate) O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester." [EC:2.1.1.77]
subset: gosubset_prok
synonym: "D-aspartyl/L-isoaspartyl methyltransferase activity" EXACT [EC:2.1.1.77]
synonym: "L-aspartyl/L-isoaspartyl protein methyltransferase activity" EXACT [EC:2.1.1.77]
synonym: "L-isoaspartyl protein carboxyl methyltransferase activity" EXACT [EC:2.1.1.77]
synonym: "L-isoaspartyl/D-aspartyl protein carboxyl methyltransferase activity" EXACT [EC:2.1.1.77]
synonym: "protein (D-aspartate) methyltransferase activity" EXACT [EC:2.1.1.77]
synonym: "protein beta-aspartate O-methyltransferase activity" EXACT [EC:2.1.1.77]
synonym: "protein D-aspartate methyltransferase activity" EXACT [EC:2.1.1.77]
synonym: "protein L-isoaspartate methyltransferase activity" EXACT [EC:2.1.1.77]
synonym: "protein L-isoaspartyl methyltransferase activity" EXACT [EC:2.1.1.77]
synonym: "protein O-methyltransferase (L-isoaspartate)" EXACT [EC:2.1.1.77]
synonym: "protein-beta-aspartate O-methyltransferase activity" EXACT [EC:2.1.1.77]
synonym: "protein-L-isoaspartate O-methyltransferase activity" EXACT [EC:2.1.1.77]
synonym: "protein-L-isoaspartate(D-aspartate) O-methyltransferase activity" EXACT [EC:2.1.1.77]
synonym: "S-adenosyl-L-methionine:protein-L-isoaspartate O-methyltransferase activity" EXACT [EC:2.1.1.77]
xref: EC:2.1.1.77
xref: MetaCyc:2.1.1.77-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
is_a: GO:0051998 ! protein carboxyl O-methyltransferase activity

[Term]
id: GO:0004720
name: protein-lysine 6-oxidase activity
namespace: molecular_function
alt_id: GO:0018056
def: "Catalysis of the reaction: peptidyl-L-lysyl-peptide + H2O + O2 = peptidyl-allysyl-peptide + NH3 + hydrogen peroxide." [EC:1.4.3.13]
synonym: "lysyl oxidase activity" EXACT [EC:1.4.3.13]
synonym: "protein-L-lysine:oxygen 6-oxidoreductase (deaminating)" EXACT [EC:1.4.3.13]
xref: EC:1.4.3.13
xref: MetaCyc:PROTEIN-LYSINE-6-OXIDASE-RXN
is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

[Term]
id: GO:0004721
name: phosphoprotein phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684]
subset: gosubset_prok
synonym: "phosphoprotein phosphohydrolase activity" EXACT [EC:3.1.3.16]
synonym: "protein phosphatase activity" EXACT []
synonym: "protein phosphatase-1 activity" NARROW [EC:3.1.3.16]
synonym: "protein phosphatase-2A activity" NARROW [EC:3.1.3.16]
synonym: "protein phosphatase-2B activity" NARROW [EC:3.1.3.16]
synonym: "protein phosphatase-2C activity" NARROW [EC:3.1.3.16]
xref: EC:3.1.3.16
xref: MetaCyc:3.1.3.16-RXN
xref: Reactome:REACT_100556 "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A, Canis familiaris"
xref: Reactome:REACT_101161 "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases, Bos taurus"
xref: Reactome:REACT_101258 "Dephosphorylation of phospho-Cdh1, Taeniopygia guttata"
xref: Reactome:REACT_101308 "Dephosphorylation of nuclear Cyclin A:phosph-Cdc2 complexes, Mus musculus"
xref: Reactome:REACT_101537 "Dephosphorylation of nuclear Cyclin A:phosph-Cdc2 complexes, Drosophila melanogaster"
xref: Reactome:REACT_102055 "Dephosphorylation of nuclear Cyclin A:phosph-Cdc2 complexes, Bos taurus"
xref: Reactome:REACT_102521 "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2, Canis familiaris"
xref: Reactome:REACT_103107 "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A, Danio rerio"
xref: Reactome:REACT_105948 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Rattus norvegicus"
xref: Reactome:REACT_106256 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Xenopus tropicalis"
xref: Reactome:REACT_107500 "Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25, Taeniopygia guttata"
xref: Reactome:REACT_107570 "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases, Drosophila melanogaster"
xref: Reactome:REACT_108174 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Gallus gallus"
xref: Reactome:REACT_109144 "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2, Drosophila melanogaster"
xref: Reactome:REACT_109225 "Dephosphorylation of nuclear Cyclin A:phosph-Cdc2 complexes, Rattus norvegicus"
xref: Reactome:REACT_109310 "Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25, Rattus norvegicus"
xref: Reactome:REACT_109345 "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A, Mus musculus"
xref: Reactome:REACT_109732 "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2, Rattus norvegicus"
xref: Reactome:REACT_110596 "Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25, Canis familiaris"
xref: Reactome:REACT_111148 "Dephosphorylation of p107 (RBL1) by PP2A, Homo sapiens"
xref: Reactome:REACT_111170 "Dephosphorylation of p130 (RBL2) by PP2A, Homo sapiens"
xref: Reactome:REACT_112020 "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A, Drosophila melanogaster"
xref: Reactome:REACT_112348 "Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25, Saccharomyces cerevisiae"
xref: Reactome:REACT_112617 "Dephosphorylation of cytoplasmic Cyclin B1:phospho-Cdc2 (Thr 14, Tyr 15) complexes by Cdc25 phosphatases, Saccharomyces cerevisiae"
xref: Reactome:REACT_112795 "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A, Saccharomyces cerevisiae"
xref: Reactome:REACT_112811 "Pp2a mediated localization of Rb protein in chromatin, Xenopus tropicalis"
xref: Reactome:REACT_112981 "Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25, Schizosaccharomyces pombe"
xref: Reactome:REACT_113855 "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases, Schizosaccharomyces pombe"
xref: Reactome:REACT_114200 "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A, Schizosaccharomyces pombe"
xref: Reactome:REACT_114550 "Dephosphorylation of cytoplasmic Cyclin B1:phospho-Cdc2 (Thr 14, Tyr 15) complexes by Cdc25 phosphatases, Schizosaccharomyces pombe"
xref: Reactome:REACT_115084 "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases, Saccharomyces cerevisiae"
xref: Reactome:REACT_1251 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Homo sapiens"
xref: Reactome:REACT_28268 "Dephosphorylation of phospho-Cdh1, Xenopus tropicalis"
xref: Reactome:REACT_28473 "Dephosphorylation of cytoplasmic Cyclin B1:phospho-Cdc2 (Thr 14, Tyr 15) complexes by Cdc25 phosphatases, Canis familiaris"
xref: Reactome:REACT_28474 "Pp2a mediated localization of Rb protein in chromatin, Canis familiaris"
xref: Reactome:REACT_28606 "Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25, Gallus gallus"
xref: Reactome:REACT_29645 "Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25, Mus musculus"
xref: Reactome:REACT_30225 "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A, Xenopus tropicalis"
xref: Reactome:REACT_33423 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Drosophila melanogaster"
xref: Reactome:REACT_421 "Pp2a mediated localization of Rb protein in chromatin, Homo sapiens"
xref: Reactome:REACT_592 "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A, Homo sapiens"
xref: Reactome:REACT_59811 "Dephosphorylation of nuclear Cyclin A:phosph-Cdc2 complexes, Canis familiaris"
xref: Reactome:REACT_6175 "Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25, Homo sapiens"
xref: Reactome:REACT_6206 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Homo sapiens"
xref: Reactome:REACT_6255 "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases, Homo sapiens"
xref: Reactome:REACT_6257 "Dephosphorylation of cytoplasmic Cyclin B1:phospho-Cdc2 (Thr 14, Tyr 15) complexes by Cdc25 phosphatases, Homo sapiens"
xref: Reactome:REACT_6294 "Dephosphorylation of nuclear Cyclin A:phosph-Cdc2 complexes, Homo sapiens"
xref: Reactome:REACT_6910 "Dephosphorylation of phospho-Cdh1, Homo sapiens"
xref: Reactome:REACT_77578 "Dephosphorylation of phospho-Cdh1, Rattus norvegicus"
xref: Reactome:REACT_77594 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Caenorhabditis elegans"
xref: Reactome:REACT_77793 "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases, Danio rerio"
xref: Reactome:REACT_78412 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Mus musculus"
xref: Reactome:REACT_78414 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Saccharomyces cerevisiae"
xref: Reactome:REACT_80229 "Dephosphorylation of phospho-Cdh1, Bos taurus"
xref: Reactome:REACT_80518 "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A, Rattus norvegicus"
xref: Reactome:REACT_81016 "Dephosphorylation of phospho-Cdh1, Sus scrofa"
xref: Reactome:REACT_81195 "Dephosphorylation of nuclear Cyclin A:phosph-Cdc2 complexes, Xenopus tropicalis"
xref: Reactome:REACT_81980 "Dephosphorylation of cytoplasmic Cyclin B1:phospho-Cdc2 (Thr 14, Tyr 15) complexes by Cdc25 phosphatases, Bos taurus"
xref: Reactome:REACT_83073 "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases, Xenopus tropicalis"
xref: Reactome:REACT_83503 "Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25, Danio rerio"
xref: Reactome:REACT_83605 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Dictyostelium discoideum"
xref: Reactome:REACT_83812 "Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25, Drosophila melanogaster"
xref: Reactome:REACT_83951 "Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25, Bos taurus"
xref: Reactome:REACT_84291 "Pp2a mediated localization of Rb protein in chromatin, Mus musculus"
xref: Reactome:REACT_84834 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Danio rerio"
xref: Reactome:REACT_84882 "Dephosphorylation of nuclear Cyclin A:phosph-Cdc2 complexes, Gallus gallus"
xref: Reactome:REACT_86262 "Dephosphorylation of phospho-Cdh1, Schizosaccharomyces pombe"
xref: Reactome:REACT_86293 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Arabidopsis thaliana"
xref: Reactome:REACT_86738 "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2, Xenopus tropicalis"
xref: Reactome:REACT_89601 "Dephosphorylation of phospho-Cdh1, Gallus gallus"
xref: Reactome:REACT_89607 "Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25, Xenopus tropicalis"
xref: Reactome:REACT_9062 "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2, Homo sapiens"
xref: Reactome:REACT_90978 "Pp2a mediated localization of Rb protein in chromatin, Taeniopygia guttata"
xref: Reactome:REACT_91918 "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2, Danio rerio"
xref: Reactome:REACT_91996 "Dephosphorylation of nuclear Cyclin A:phosph-Cdc2 complexes, Danio rerio"
xref: Reactome:REACT_92154 "Dephosphorylation of phospho-Cdh1, Canis familiaris"
xref: Reactome:REACT_92312 "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2, Bos taurus"
xref: Reactome:REACT_92765 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Oryza sativa"
xref: Reactome:REACT_93167 "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2, Mus musculus"
xref: Reactome:REACT_93324 "Pp2a mediated localization of Rb protein in chromatin, Dictyostelium discoideum"
xref: Reactome:REACT_94004 "Dephosphorylation of phospho-Cdh1, Danio rerio"
xref: Reactome:REACT_95049 "Dephosphorylation of phospho-Cdh1, Mus musculus"
xref: Reactome:REACT_95090 "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases, Mus musculus"
xref: Reactome:REACT_95688 "Dephosphorylation of cytoplasmic Cyclin B1:phospho-Cdc2 (Thr 14, Tyr 15) complexes by Cdc25 phosphatases, Drosophila melanogaster"
xref: Reactome:REACT_95930 "Dephosphorylation of cytoplasmic Cyclin B1:phospho-Cdc2 (Thr 14, Tyr 15) complexes by Cdc25 phosphatases, Xenopus tropicalis"
xref: Reactome:REACT_95992 "Dephosphorylation of cytoplasmic Cyclin B1:phospho-Cdc2 (Thr 14, Tyr 15) complexes by Cdc25 phosphatases, Mus musculus"
xref: Reactome:REACT_97239 "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases, Canis familiaris"
xref: Reactome:REACT_97616 "Dephosphorylation of nuclear Cyclin A:phosph-Cdc2 complexes, Taeniopygia guttata"
xref: Reactome:REACT_98140 "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A, Bos taurus"
xref: Reactome:REACT_98946 "Dephosphorylation of phospho-Cdh1, Saccharomyces cerevisiae"
xref: Reactome:REACT_98958 "Dephosphorylation of cytoplasmic Cyclin B1:phospho-Cdc2 (Thr 14, Tyr 15) complexes by Cdc25 phosphatases, Rattus norvegicus"
xref: Reactome:REACT_98967 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Schizosaccharomyces pombe"
xref: Reactome:REACT_99508 "Dephosphorylation of cytoplasmic Cyclin B1:phospho-Cdc2 (Thr 14, Tyr 15) complexes by Cdc25 phosphatases, Danio rerio"
xref: Reactome:REACT_99511 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Taeniopygia guttata"
xref: Reactome:REACT_99512 "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases, Rattus norvegicus"
is_a: GO:0016791 ! phosphatase activity
relationship: part_of GO:0006470 ! protein dephosphorylation

[Term]
id: GO:0004722
name: protein serine/threonine phosphatase activity
namespace: molecular_function
alt_id: GO:0000158
alt_id: GO:0000163
alt_id: GO:0008598
alt_id: GO:0008600
alt_id: GO:0015071
alt_id: GO:0030357
alt_id: GO:0030358
alt_id: GO:0030360
alt_id: GO:0030361
def: "Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate." [GOC:bf]
subset: gosubset_prok
synonym: "3-hydroxy 3-methylglutaryl coenzymeA reductase phosphatase" NARROW [EC:3.1.3.16]
synonym: "Aspergillus awamori acid protein phosphatase" NARROW [EC:3.1.3.16]
synonym: "BCKDH phosphatase" NARROW [EC:3.1.3.16]
synonym: "branched-chain alpha-keto acid dehydrogenase phosphatase" NARROW [EC:3.1.3.16]
synonym: "calcineurin" NARROW []
synonym: "casein phosphatase" NARROW [EC:3.1.3.16]
synonym: "HMG-CoA reductase phosphatase" NARROW [EC:3.1.3.16]
synonym: "phosphatase 2A" NARROW [EC:3.1.3.16]
synonym: "phosphatase 2B" NARROW [EC:3.1.3.16]
synonym: "phosphatase C-II" NARROW [EC:3.1.3.16]
synonym: "phosphatase H-II" NARROW [EC:3.1.3.16]
synonym: "phosphatase I" NARROW [EC:3.1.3.16]
synonym: "phosphatase IB" NARROW [EC:3.1.3.16]
synonym: "phosphatase II" NARROW [EC:3.1.3.16]
synonym: "phosphatase III" NARROW [EC:3.1.3.16]
synonym: "phosphatase IV" NARROW [EC:3.1.3.16]
synonym: "phosphatase SP" NARROW [EC:3.1.3.16]
synonym: "phosphopyruvate dehydrogenase phosphatase" NARROW [EC:3.1.3.16]
synonym: "phosphospectrin phosphatase" NARROW [EC:3.1.3.16]
synonym: "polycation modulated (PCM-) phosphatase" NARROW [EC:3.1.3.16]
synonym: "protein D phosphatase" NARROW [EC:3.1.3.16]
synonym: "protein phosphatase type 1 activity" NARROW []
synonym: "protein phosphatase type 1, intrinsic catalyst activity" NARROW []
synonym: "protein phosphatase type 2A activity" NARROW []
synonym: "protein phosphatase type 2A, intrinsic catalyst activity" NARROW []
synonym: "protein phosphatase type 2B activity" NARROW []
synonym: "protein phosphatase type 2B, intrinsic catalyst activity" NARROW []
synonym: "protein phosphatase type 2C activity" NARROW []
synonym: "protein phosphatase type 4 activity" NARROW []
synonym: "protein phosphatase type 4, intrinsic catalyst activity" NARROW []
synonym: "protein phosphatase X" NARROW []
synonym: "serine/threonine specific protein phosphatase activity" EXACT []
xref: Reactome:REACT_102328 "AMPK is dephosphorylated, Gallus gallus"
xref: Reactome:REACT_103273 "AMPK is dephosphorylated, Danio rerio"
xref: Reactome:REACT_104935 "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate, Rattus norvegicus"
xref: Reactome:REACT_105168 "ERKs are inactivated by protein phosphatase 2A, Bos taurus"
xref: Reactome:REACT_105744 "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate, Gallus gallus"
xref: Reactome:REACT_106758 "phosphorylated perilipin + H2O -> perilipin + orthophosphate, Taeniopygia guttata"
xref: Reactome:REACT_108076 "DARPP-32 is dephosphorylated on Thr34 by PP2B, Sus scrofa"
xref: Reactome:REACT_108095 "phosphorylated perilipin + H2O -> perilipin + orthophosphate, Danio rerio"
xref: Reactome:REACT_109701 "AMPK is dephosphorylated, Caenorhabditis elegans"
xref: Reactome:REACT_110128 "AMPK is dephosphorylated, Sus scrofa"
xref: Reactome:REACT_111094 "PPA2A dephosphorylates SPRY2, Homo sapiens"
xref: Reactome:REACT_112525 "PHLPP dephosphorylates S473 in AKT, Gallus gallus"
xref: Reactome:REACT_112659 "AMPK is dephosphorylated, Saccharomyces cerevisiae"
xref: Reactome:REACT_113935 "PHLPP dephosphorylates S473 in AKT, Xenopus tropicalis"
xref: Reactome:REACT_114990 "DARPP-32 is dephosphorylated on Thr34 by PP2B, Xenopus tropicalis"
xref: Reactome:REACT_116150 "PP2B dephosphorylates DARPP-32 on T34, Rattus norvegicus"
xref: Reactome:REACT_12403 "PHLPP dephosphorylates S473 in AKT, Homo sapiens"
xref: Reactome:REACT_12539 "ERKs are inactivated by protein phosphatase 2A, Homo sapiens"
xref: Reactome:REACT_15438 "DARPP-32 is dephosphorylated on Thr75 by PP2A, Homo sapiens"
xref: Reactome:REACT_15494 "DARPP-32 is dephosphorylated on Thr34 by PP2B, Homo sapiens"
xref: Reactome:REACT_1705 "phosphorylated perilipin + H2O -> perilipin + orthophosphate, Rattus norvegicus"
xref: Reactome:REACT_19304 "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate, Homo sapiens"
xref: Reactome:REACT_21418 "AMPK is dephosphorylated, Homo sapiens"
xref: Reactome:REACT_29362 "DARPP-32 is dephosphorylated on Thr75 by PP2A, Rattus norvegicus"
xref: Reactome:REACT_30903 "DARPP-32 is dephosphorylated on Thr75 by PP2A, Canis familiaris"
xref: Reactome:REACT_31424 "DARPP-32 is dephosphorylated on Thr75 by PP2A, Bos taurus"
xref: Reactome:REACT_31944 "AMPK is dephosphorylated, Taeniopygia guttata"
xref: Reactome:REACT_32258 "ERKs are inactivated by protein phosphatase 2A, Taeniopygia guttata"
xref: Reactome:REACT_33433 "PHLPP dephosphorylates S473 in AKT, Rattus norvegicus"
xref: Reactome:REACT_33609 "DARPP-32 is dephosphorylated on Thr34 by PP2B, Mus musculus"
xref: Reactome:REACT_403 "phosphorylated perilipin + H2O -> perilipin + orthophosphate, Homo sapiens"
xref: Reactome:REACT_60521 "phosphorylated perilipin + H2O -> perilipin + orthophosphate, Sus scrofa"
xref: Reactome:REACT_75794 "Decay of mRNA in SMG6:SMG5:SMG7:mRNA Complex, Homo sapiens"
xref: Reactome:REACT_77118 "DARPP-32 is dephosphorylated on Thr34 by PP2B, Bos taurus"
xref: Reactome:REACT_77285 "PHLPP dephosphorylates S473 in AKT, Drosophila melanogaster"
xref: Reactome:REACT_77773 "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate, Bos taurus"
xref: Reactome:REACT_79893 "AMPK is dephosphorylated, Drosophila melanogaster"
xref: Reactome:REACT_80418 "PHLPP dephosphorylates S473 in AKT, Taeniopygia guttata"
xref: Reactome:REACT_81032 "ERKs are inactivated by protein phosphatase 2A, Dictyostelium discoideum"
xref: Reactome:REACT_82252 "AMPK is dephosphorylated, Mus musculus"
xref: Reactome:REACT_82455 "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate, Taeniopygia guttata"
xref: Reactome:REACT_82736 "ERKs are inactivated by protein phosphatase 2A, Mus musculus"
xref: Reactome:REACT_82848 "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate, Danio rerio"
xref: Reactome:REACT_83123 "AMPK is dephosphorylated, Canis familiaris"
xref: Reactome:REACT_84149 "phosphorylated perilipin + H2O -> perilipin + orthophosphate, Canis familiaris"
xref: Reactome:REACT_84173 "AMPK is dephosphorylated, Rattus norvegicus"
xref: Reactome:REACT_87477 "phosphorylated perilipin + H2O -> perilipin + orthophosphate, Xenopus tropicalis"
xref: Reactome:REACT_87535 "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate, Mus musculus"
xref: Reactome:REACT_87738 "ERKs are inactivated by protein phosphatase 2A, Rattus norvegicus"
xref: Reactome:REACT_89253 "phosphorylated perilipin + H2O -> perilipin + orthophosphate, Mus musculus"
xref: Reactome:REACT_92068 "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate, Xenopus tropicalis"
xref: Reactome:REACT_92797 "AMPK is dephosphorylated, Xenopus tropicalis"
xref: Reactome:REACT_93522 "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate, Drosophila melanogaster"
xref: Reactome:REACT_93551 "PHLPP dephosphorylates S473 in AKT, Mus musculus"
xref: Reactome:REACT_93922 "phosphorylated perilipin + H2O -> perilipin + orthophosphate, Bos taurus"
xref: Reactome:REACT_94309 "ERKs are inactivated by protein phosphatase 2A, Drosophila melanogaster"
xref: Reactome:REACT_94590 "ERKs are inactivated by protein phosphatase 2A, Canis familiaris"
xref: Reactome:REACT_94855 "PHLPP dephosphorylates S473 in AKT, Canis familiaris"
xref: Reactome:REACT_95676 "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate, Canis familiaris"
xref: Reactome:REACT_96055 "DARPP-32 is dephosphorylated on Thr34 by PP2B, Danio rerio"
xref: Reactome:REACT_96980 "DARPP-32 is dephosphorylated on Thr75 by PP2A, Mus musculus"
xref: Reactome:REACT_98890 "phosphorylated perilipin + H2O -> perilipin + orthophosphate, Gallus gallus"
is_a: GO:0004721 ! phosphoprotein phosphatase activity

[Term]
id: GO:0004723
name: calcium-dependent protein serine/threonine phosphatase activity
namespace: molecular_function
alt_id: GO:0008596
def: "Catalysis of the reactions: protein serine phosphate + H2O = protein serine + phosphate; and protein threonine phosphate + H2O = protein threonine + phosphate. These reactions require the presence of calcium ions." [EC:3.1.3.16, GOC:mah]
synonym: "calcineurin" NARROW []
synonym: "calcium-dependent protein serine/threonine phosphatase, intrinsic catalyst activity" EXACT []
is_a: GO:0004722 ! protein serine/threonine phosphatase activity

[Term]
id: GO:0004724
name: magnesium-dependent protein serine/threonine phosphatase activity
namespace: molecular_function
def: "Catalysis of the reactions: protein serine phosphate + H2O = protein serine + phosphate; and protein threonine phosphate + H2O = protein threonine + phosphate. These reactions require the presence of magnesium." [EC:3.1.3.16]
is_a: GO:0004722 ! protein serine/threonine phosphatase activity

[Term]
id: GO:0004725
name: protein tyrosine phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
subset: gosubset_prok
synonym: "[phosphotyrosine]protein phosphatase activity" EXACT [EC:3.1.3.48]
synonym: "phosphoprotein phosphatase (phosphotyrosine) activity" EXACT [EC:3.1.3.48]
synonym: "phosphotyrosine histone phosphatase activity" EXACT [EC:3.1.3.48]
synonym: "phosphotyrosine phosphatase activity" EXACT [EC:3.1.3.48]
synonym: "phosphotyrosine protein phosphatase activity" EXACT [EC:3.1.3.48]
synonym: "phosphotyrosylprotein phosphatase activity" EXACT [EC:3.1.3.48]
synonym: "PPT-phosphatase activity" EXACT [EC:3.1.3.48]
synonym: "protein phosphotyrosine phosphatase activity" EXACT [EC:3.1.3.48]
synonym: "protein-tyrosine-phosphatase activity" EXACT [EC:3.1.3.48]
synonym: "protein-tyrosine-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.48]
synonym: "PTP-phosphatase activity" EXACT [EC:3.1.3.48]
synonym: "PTPase activity" EXACT [EC:3.1.3.48]
synonym: "tyrosine O-phosphate phosphatase activity" EXACT [EC:3.1.3.48]
synonym: "tyrosylprotein phosphatase activity" EXACT [EC:3.1.3.48]
xref: EC:3.1.3.48
xref: MetaCyc:PROTEIN-TYROSINE-PHOSPHATASE-RXN
xref: Reactome:REACT_100540 "ERKs are inactivated by dual-specific phosphatases (DUSPs), Mus musculus"
xref: Reactome:REACT_101149 "Dephosphorylation of NCAM1 bound pFyn, Rattus norvegicus"
xref: Reactome:REACT_103930 "ERKs are inactivated by dual-specific phosphatases (DUSPs), Canis familiaris"
xref: Reactome:REACT_104864 "ERKs are inactivated by dual-specific phosphatases (DUSPs), Bos taurus"
xref: Reactome:REACT_105172 "Dephosphorylation of NCAM1 bound pFyn, Bos taurus"
xref: Reactome:REACT_107803 "ERKs are inactivated by dual-specific phosphatases (DUSPs), Gallus gallus"
xref: Reactome:REACT_108914 "Dephosphorylation of CD3-zeta by PD-1 bound phosphatases, Rattus norvegicus"
xref: Reactome:REACT_109643 "Dephosphorylation of NCAM1 bound pFyn, Danio rerio"
xref: Reactome:REACT_111038 "Ptp1b dephosphorylates Jak2, Mus musculus"
xref: Reactome:REACT_111048 "SHP1 (PTPN6) dephosphorylates JAK2, Homo sapiens"
xref: Reactome:REACT_111061 "PTP1B dephosphorylates GHR, Homo sapiens"
xref: Reactome:REACT_111128 "PTP1B dephosphorylates JAK2, Homo sapiens"
xref: Reactome:REACT_111157 "SHP2 dephosphorylates SPRY2, Homo sapiens"
xref: Reactome:REACT_111193 "Shp1 (Ptpn6) dephosphorylates Jak2, Mus musculus"
xref: Reactome:REACT_112085 "ERKs are inactivated by dual-specific phosphatases (DUSPs), Oryza sativa"
xref: Reactome:REACT_112153 "Dephosphorylation of inactive SRC by PTPB1, Drosophila melanogaster"
xref: Reactome:REACT_113070 "ERKs are inactivated by dual-specific phosphatases (DUSPs), Caenorhabditis elegans"
xref: Reactome:REACT_114866 "ERKs are inactivated by dual-specific phosphatases (DUSPs), Arabidopsis thaliana"
xref: Reactome:REACT_115220 "ERKs are inactivated by dual-specific phosphatases (DUSPs), Dictyostelium discoideum"
xref: Reactome:REACT_115381 "Dephosphorylation of inactive SRC by PTPB1, Xenopus tropicalis"
xref: Reactome:REACT_12439 "ERKs are inactivated by dual-specific phosphatases (DUSPs), Homo sapiens"
xref: Reactome:REACT_12446 "Dephosphorylation of Lck-pY505 by CD45, Homo sapiens"
xref: Reactome:REACT_1411 "De-phosphorylation of SHC, Homo sapiens"
xref: Reactome:REACT_15464 "Dephosphorylation of inactive SRC by PTPB1, Homo sapiens"
xref: Reactome:REACT_1810 "De-phosphorylation of IRS, Homo sapiens"
xref: Reactome:REACT_18389 "Dephosphorylation of NCAM1 bound pFyn, Homo sapiens"
xref: Reactome:REACT_18414 "Dephosphorylation of NCAM1 bound pFyn, Homo sapiens"
xref: Reactome:REACT_19146 "Dephosphorylation of CD3-zeta by PD-1 bound phosphatases, Homo sapiens"
xref: Reactome:REACT_22109 "Dephosphorylation of pL1 (Y1176), Homo sapiens"
xref: Reactome:REACT_23816 "SHP1 and SHP2 dephosphorylate Y628 of IL3RB, Homo sapiens"
xref: Reactome:REACT_24939 "Dephosphorylation of STAT1 by SHP2, Homo sapiens"
xref: Reactome:REACT_25185 "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP, Homo sapiens"
xref: Reactome:REACT_25190 "Dephosphorylation of JAKs by PTPs, Homo sapiens"
xref: Reactome:REACT_25289 "Dephosphorylation of JAK1 by SHP1, Homo sapiens"
xref: Reactome:REACT_25311 "Dephosphorylation of Jaks by Ptps, Mus musculus"
xref: Reactome:REACT_25329 "Dephosphorylation of TYK2 by PTP1B, Homo sapiens"
xref: Reactome:REACT_28210 "Dephosphorylation of inactive SRC by PTPB1, Bos taurus"
xref: Reactome:REACT_32566 "Dephosphorylation of CD3-zeta by PD-1 bound phosphatases, Mus musculus"
xref: Reactome:REACT_34493 "Dephosphorylation of NCAM1 bound pFyn, Gallus gallus"
xref: Reactome:REACT_453 "Insulin receptor de-phosphorylation, Homo sapiens"
xref: Reactome:REACT_77215 "Dephosphorylation of inactive SRC by PTPB1, Danio rerio"
xref: Reactome:REACT_79081 "ERKs are inactivated by dual-specific phosphatases (DUSPs), Drosophila melanogaster"
xref: Reactome:REACT_81528 "ERKs are inactivated by dual-specific phosphatases (DUSPs), Danio rerio"
xref: Reactome:REACT_82080 "Dephosphorylation of Lck-pY505 by CD45, Mus musculus"
xref: Reactome:REACT_83292 "ERKs are inactivated by dual-specific phosphatases (DUSPs), Taeniopygia guttata"
xref: Reactome:REACT_86824 "Dephosphorylation of NCAM1 bound pFyn, Canis familiaris"
xref: Reactome:REACT_88819 "Dephosphorylation of NCAM1 bound pFyn, Taeniopygia guttata"
xref: Reactome:REACT_90186 "Dephosphorylation of NCAM1 bound pFyn, Xenopus tropicalis"
xref: Reactome:REACT_91327 "Dephosphorylation of NCAM1 bound pFyn, Mus musculus"
xref: Reactome:REACT_91510 "Dephosphorylation of inactive SRC by PTPB1, Canis familiaris"
xref: Reactome:REACT_92520 "ERKs are inactivated by dual-specific phosphatases (DUSPs), Xenopus tropicalis"
xref: Reactome:REACT_92699 "ERKs are inactivated by dual-specific phosphatases (DUSPs), Rattus norvegicus"
xref: Reactome:REACT_93431 "Dephosphorylation of inactive SRC by PTPB1, Mus musculus"
xref: Reactome:REACT_93753 "Dephosphorylation of inactive SRC by PTPB1, Sus scrofa"
xref: Reactome:REACT_95709 "Dephosphorylation of Lck-pY505 by CD45, Rattus norvegicus"
xref: Reactome:REACT_97438 "ERKs are inactivated by dual-specific phosphatases (DUSPs), Sus scrofa"
xref: Reactome:REACT_97978 "Dephosphorylation of NCAM1 bound pFyn, Sus scrofa"
xref: Reactome:REACT_98860 "Dephosphorylation of inactive SRC by PTPB1, Rattus norvegicus"
is_a: GO:0004721 ! phosphoprotein phosphatase activity
relationship: part_of GO:0035335 ! peptidyl-tyrosine dephosphorylation

[Term]
id: GO:0004726
name: non-membrane spanning protein tyrosine phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate." [EC:3.1.3.48]
subset: gosubset_prok
xref: Reactome:REACT_100972 "Dephosphorylation of PAG by SHP2, Mus musculus"
xref: Reactome:REACT_102958 "Dephosphorylation of Gab1 by SHP2, Danio rerio"
xref: Reactome:REACT_103032 "SHP2 dephosphorylates Tyr 992 on EGFR, Canis familiaris"
xref: Reactome:REACT_104134 "Dephosphorylation of PAG by SHP2, Taeniopygia guttata"
xref: Reactome:REACT_105764 "Dephosphorylation of PAG by SHP2, Bos taurus"
xref: Reactome:REACT_107280 "SHP2 dephosphorylates Tyr 992 on EGFR, Danio rerio"
xref: Reactome:REACT_107499 "SHP2 dephosphorylates Tyr 992 on EGFR, Xenopus tropicalis"
xref: Reactome:REACT_108113 "Dephosphorylation of PAG by SHP2, Xenopus tropicalis"
xref: Reactome:REACT_108587 "Sustained activation of SRC kinase by SHP2, Bos taurus"
xref: Reactome:REACT_109376 "Dephosphorylation of Gab1 by SHP2, Mus musculus"
xref: Reactome:REACT_109915 "Sustained activation of SRC kinase by SHP2, Rattus norvegicus"
xref: Reactome:REACT_12390 "Dephosphorylation of PAG by SHP2, Homo sapiens"
xref: Reactome:REACT_12601 "Sustained activation of SRC kinase by SHP2, Homo sapiens"
xref: Reactome:REACT_12605 "Dephosphorylation of Gab1 by SHP2, Homo sapiens"
xref: Reactome:REACT_12629 "SHP2 dephosphorylates Tyr 992 on EGFR, Homo sapiens"
xref: Reactome:REACT_29401 "SHP2 dephosphorylates Tyr 992 on EGFR, Bos taurus"
xref: Reactome:REACT_29520 "SHP2 dephosphorylates Tyr 992 on EGFR, Rattus norvegicus"
xref: Reactome:REACT_31244 "SHP2 dephosphorylates Tyr 992 on EGFR, Taeniopygia guttata"
xref: Reactome:REACT_31938 "Dephosphorylation of Gab1 by SHP2, Xenopus tropicalis"
xref: Reactome:REACT_32045 "Dephosphorylation of PAG by SHP2, Danio rerio"
xref: Reactome:REACT_45043 "Dephosphorylation of PAG by SHP2, Gallus gallus"
xref: Reactome:REACT_63200 "Dephosphorylation of PAG by SHP2, Canis familiaris"
xref: Reactome:REACT_78598 "SHP2 dephosphorylates Tyr 992 on EGFR, Mus musculus"
xref: Reactome:REACT_79382 "Dephosphorylation of Gab1 by SHP2, Gallus gallus"
xref: Reactome:REACT_81836 "Sustained activation of SRC kinase by SHP2, Gallus gallus"
xref: Reactome:REACT_83797 "Sustained activation of SRC kinase by SHP2, Mus musculus"
xref: Reactome:REACT_84801 "Dephosphorylation of Gab1 by SHP2, Rattus norvegicus"
xref: Reactome:REACT_87757 "Dephosphorylation of Gab1 by SHP2, Canis familiaris"
xref: Reactome:REACT_89349 "Dephosphorylation of Gab1 by SHP2, Taeniopygia guttata"
xref: Reactome:REACT_90674 "Dephosphorylation of Gab1 by SHP2, Bos taurus"
xref: Reactome:REACT_93120 "Sustained activation of SRC kinase by SHP2, Danio rerio"
xref: Reactome:REACT_93665 "Sustained activation of SRC kinase by SHP2, Taeniopygia guttata"
xref: Reactome:REACT_98173 "SHP2 dephosphorylates Tyr 992 on EGFR, Gallus gallus"
xref: Reactome:REACT_98185 "Sustained activation of SRC kinase by SHP2, Xenopus tropicalis"
is_a: GO:0004725 ! protein tyrosine phosphatase activity

[Term]
id: GO:0004727
name: prenylated protein tyrosine phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: prenylated-protein tyrosine phosphate + H2O = prenylated-protein tyrosine + phosphate." [EC:3.1.3.48]
is_a: GO:0004725 ! protein tyrosine phosphatase activity

[Term]
id: GO:0004728
name: receptor signaling protein tyrosine phosphatase activity
namespace: molecular_function
def: "Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
synonym: "receptor signalling protein tyrosine phosphatase activity" EXACT []
is_a: GO:0004725 ! protein tyrosine phosphatase activity
is_a: GO:0005057 ! receptor signaling protein activity
relationship: part_of GO:0023014 ! signal transduction by protein phosphorylation

[Term]
id: GO:0004729
name: oxygen-dependent protoporphyrinogen oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3 O(2) + protoporphyrinogen IX = 3 H(2)O(2) + protoporphyrin IX." [EC:1.3.3.4, RHEA:25579]
subset: gosubset_prok
synonym: "protoporphyrinogen-IX:oxygen oxidoreductase activity" EXACT [EC:1.3.3.4]
xref: EC:1.3.3.4
xref: KEGG:R03222
xref: MetaCyc:PROTOPORGENOXI-RXN
xref: Reactome:REACT_104201 "Oxidation of protoporphyrinogen IX to protoporphyrin IX, Mus musculus"
xref: Reactome:REACT_115922 "2 protoporphyrinogen IX + 3 O2 => 2 protoporphyrin IX + 6 H2O, Gallus gallus"
xref: Reactome:REACT_29704 "Oxidation of protoporphyrinogen IX to protoporphyrin IX, Xenopus tropicalis"
xref: Reactome:REACT_30219 "Oxidation of protoporphyrinogen IX to protoporphyrin IX, Arabidopsis thaliana"
xref: Reactome:REACT_30356 "Oxidation of protoporphyrinogen IX to protoporphyrin IX, Mycobacterium tuberculosis"
xref: Reactome:REACT_33094 "Oxidation of protoporphyrinogen IX to protoporphyrin IX, Rattus norvegicus"
xref: Reactome:REACT_33940 "Oxidation of protoporphyrinogen IX to protoporphyrin IX, Bos taurus"
xref: Reactome:REACT_38382 "Oxidation of protoporphyrinogen IX to protoporphyrin IX, Canis familiaris"
xref: Reactome:REACT_81276 "Oxidation of protoporphyrinogen IX to protoporphyrin IX, Dictyostelium discoideum"
xref: Reactome:REACT_85929 "Oxidation of protoporphyrinogen IX to protoporphyrin IX, Danio rerio"
xref: Reactome:REACT_86631 "Oxidation of protoporphyrinogen IX to protoporphyrin IX, Drosophila melanogaster"
xref: Reactome:REACT_87507 "Oxidation of protoporphyrinogen IX to protoporphyrin IX, Schizosaccharomyces pombe"
xref: Reactome:REACT_90128 "Oxidation of protoporphyrinogen IX to protoporphyrin IX, Sus scrofa"
xref: Reactome:REACT_91379 "Oxidation of protoporphyrinogen IX to protoporphyrin IX, Saccharomyces cerevisiae"
xref: Reactome:REACT_9418 "Oxidation of protoporphyrinogen IX to protoporphyrin IX, Homo sapiens"
xref: Reactome:REACT_94800 "Oxidation of protoporphyrinogen IX to protoporphyrin IX, Oryza sativa"
xref: Reactome:REACT_98849 "Oxidation of protoporphyrinogen IX to protoporphyrin IX, Staphylococcus aureus N315"
xref: RHEA:25579
is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor
is_a: GO:0070818 ! protoporphyrinogen oxidase activity

[Term]
id: GO:0004730
name: pseudouridylate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-ribose 5-phosphate + uracil = H(2)O + pseudouridine 5'-phosphate." [EC:4.2.1.70, RHEA:18340]
comment: Note that this term should not be confused with 'pseudouridine synthase activity ; GO:0009982', which refers to the intramolecular isomerization of uridine to pseudouridine.
subset: gosubset_prok
synonym: "5-ribosyluracil 5-phosphate synthetase activity" EXACT [EC:4.2.1.70]
synonym: "pseudouridine monophosphate synthase activity" EXACT []
synonym: "pseudouridine monophosphate synthetase activity" EXACT [EC:4.2.1.70]
synonym: "pseudouridine-5'-phosphate glycosidase activity" EXACT []
synonym: "pseudouridylate synthetase activity" EXACT [EC:4.2.1.70]
synonym: "pseudouridylic acid synthetase activity" EXACT [EC:4.2.1.70]
synonym: "psiUMP synthetase activity" EXACT [EC:4.2.1.70]
synonym: "uracil hydro-lyase (adding D-ribose 5-phosphate)" EXACT [EC:4.2.1.70]
synonym: "uracil hydro-lyase (adding D-ribose 5-phosphate; pseudouridine-5'-phosphate-forming)" EXACT [EC:4.2.1.70]
synonym: "uracil hydrolyase activity" RELATED [EC:4.2.1.70]
xref: EC:4.2.1.70
xref: KEGG:R01055
xref: MetaCyc:PSEUDOURIDYLATE-SYNTHASE-RXN
xref: RHEA:18340
is_a: GO:0016836 ! hydro-lyase activity
relationship: part_of GO:0001522 ! pseudouridine synthesis

[Term]
id: GO:0004731
name: purine-nucleoside phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate." [EC:2.4.2.1]
subset: gosubset_prok
synonym: "inosine phosphorylase activity" NARROW [EC:2.4.2.1]
synonym: "inosine-guanosine phosphorylase activity" EXACT [EC:2.4.2.1]
synonym: "PNPase activity" EXACT [EC:2.4.2.1]
synonym: "PUNPI" RELATED [EC:2.4.2.1]
synonym: "PUNPII" RELATED [EC:2.4.2.1]
synonym: "purine deoxynucleoside phosphorylase activity" EXACT [EC:2.4.2.1]
synonym: "purine deoxyribonucleoside phosphorylase activity" EXACT [EC:2.4.2.1]
synonym: "purine nucleoside phosphorylase activity" EXACT [EC:2.4.2.1]
synonym: "purine ribonucleoside phosphorylase activity" EXACT [EC:2.4.2.1]
synonym: "purine-nucleoside:phosphate ribosyltransferase activity" EXACT [EC:2.4.2.1]
xref: EC:2.4.2.1
xref: MetaCyc:PNP-RXN
xref: Reactome:REACT_101377 "(deoxy)inosine + orthophosphate <=> hypoxanthine + (deoxy)ribose 1-phosphate [NP], Escherichia coli"
xref: Reactome:REACT_101795 "guanine + (deoxy)ribose 1-phosphate <=> (deoxy)guanosine + orthophosphate [NP], Rattus norvegicus"
xref: Reactome:REACT_103023 "(deoxy)guanosine + orthophosphate <=> guanine + (deoxy)ribose 1-phosphate [NP], Saccharomyces cerevisiae"
xref: Reactome:REACT_1040 "guanine + (deoxy)ribose 1-phosphate <=> (deoxy)guanosine + orthophosphate [NP], Homo sapiens"
xref: Reactome:REACT_104353 "(deoxy)inosine + orthophosphate <=> hypoxanthine + (deoxy)ribose 1-phosphate [NP], Xenopus tropicalis"
xref: Reactome:REACT_104371 "hypoxanthine + (deoxy)ribose 1-phosphate <=> (deoxy)inosine + orthophosphate [NP], Caenorhabditis elegans"
xref: Reactome:REACT_104483 "(deoxy)guanosine + orthophosphate <=> guanine + (deoxy)ribose 1-phosphate [NP], Schizosaccharomyces pombe"
xref: Reactome:REACT_104884 "(deoxy)guanosine + orthophosphate <=> guanine + (deoxy)ribose 1-phosphate [NP], Xenopus tropicalis"
xref: Reactome:REACT_105402 "hypoxanthine + (deoxy)ribose 1-phosphate <=> (deoxy)inosine + orthophosphate [NP], Bos taurus"
xref: Reactome:REACT_105938 "hypoxanthine + (deoxy)ribose 1-phosphate <=> (deoxy)inosine + orthophosphate [NP], Sus scrofa"
xref: Reactome:REACT_108434 "guanine + (deoxy)ribose 1-phosphate <=> (deoxy)guanosine + orthophosphate [NP], Mycobacterium tuberculosis"
xref: Reactome:REACT_108845 "hypoxanthine + (deoxy)ribose 1-phosphate <=> (deoxy)inosine + orthophosphate [NP], Mus musculus"
xref: Reactome:REACT_109206 "guanine + (deoxy)ribose 1-phosphate <=> (deoxy)guanosine + orthophosphate [NP], Saccharomyces cerevisiae"
xref: Reactome:REACT_110314 "(deoxy)inosine + orthophosphate <=> hypoxanthine + (deoxy)ribose 1-phosphate [NP], Taeniopygia guttata"
xref: Reactome:REACT_116164 "inosine + orthophosphate <=> hypoxanthine + D-ribose 1-phosphate, Gallus gallus"
xref: Reactome:REACT_1518 "(deoxy)inosine + orthophosphate <=> hypoxanthine + (deoxy)ribose 1-phosphate [NP], Homo sapiens"
xref: Reactome:REACT_1636 "hypoxanthine + (deoxy)ribose 1-phosphate <=> (deoxy)inosine + orthophosphate [NP], Homo sapiens"
xref: Reactome:REACT_29320 "guanine + (deoxy)ribose 1-phosphate <=> (deoxy)guanosine + orthophosphate [NP], Taeniopygia guttata"
xref: Reactome:REACT_29370 "guanine + (deoxy)ribose 1-phosphate <=> (deoxy)guanosine + orthophosphate [NP], Xenopus tropicalis"
xref: Reactome:REACT_29475 "(deoxy)inosine + orthophosphate <=> hypoxanthine + (deoxy)ribose 1-phosphate [NP], Saccharomyces cerevisiae"
xref: Reactome:REACT_30448 "guanine + (deoxy)ribose 1-phosphate <=> (deoxy)guanosine + orthophosphate [NP], Drosophila melanogaster"
xref: Reactome:REACT_31201 "hypoxanthine + (deoxy)ribose 1-phosphate <=> (deoxy)inosine + orthophosphate [NP], Gallus gallus"
xref: Reactome:REACT_32032 "(deoxy)inosine + orthophosphate <=> hypoxanthine + (deoxy)ribose 1-phosphate [NP], Caenorhabditis elegans"
xref: Reactome:REACT_32671 "(deoxy)inosine + orthophosphate <=> hypoxanthine + (deoxy)ribose 1-phosphate [NP], Rattus norvegicus"
xref: Reactome:REACT_33350 "(deoxy)guanosine + orthophosphate <=> guanine + (deoxy)ribose 1-phosphate [NP], Caenorhabditis elegans"
xref: Reactome:REACT_41134 "(deoxy)guanosine + orthophosphate <=> guanine + (deoxy)ribose 1-phosphate [NP], Bos taurus"
xref: Reactome:REACT_758 "(deoxy)guanosine + orthophosphate <=> guanine + (deoxy)ribose 1-phosphate [NP], Homo sapiens"
xref: Reactome:REACT_77184 "hypoxanthine + (deoxy)ribose 1-phosphate <=> (deoxy)inosine + orthophosphate [NP], Mycobacterium tuberculosis"
xref: Reactome:REACT_77403 "(deoxy)inosine + orthophosphate <=> hypoxanthine + (deoxy)ribose 1-phosphate [NP], Canis familiaris"
xref: Reactome:REACT_77461 "(deoxy)inosine + orthophosphate <=> hypoxanthine + (deoxy)ribose 1-phosphate [NP], Schizosaccharomyces pombe"
xref: Reactome:REACT_79445 "(deoxy)guanosine + orthophosphate <=> guanine + (deoxy)ribose 1-phosphate [NP], Drosophila melanogaster"
xref: Reactome:REACT_80669 "guanine + (deoxy)ribose 1-phosphate <=> (deoxy)guanosine + orthophosphate [NP], Escherichia coli"
xref: Reactome:REACT_81640 "(deoxy)guanosine + orthophosphate <=> guanine + (deoxy)ribose 1-phosphate [NP], Taeniopygia guttata"
xref: Reactome:REACT_82113 "hypoxanthine + (deoxy)ribose 1-phosphate <=> (deoxy)inosine + orthophosphate [NP], Canis familiaris"
xref: Reactome:REACT_82584 "(deoxy)guanosine + orthophosphate <=> guanine + (deoxy)ribose 1-phosphate [NP], Sus scrofa"
xref: Reactome:REACT_82660 "guanine + (deoxy)ribose 1-phosphate <=> (deoxy)guanosine + orthophosphate [NP], Mus musculus"
xref: Reactome:REACT_82690 "guanine + (deoxy)ribose 1-phosphate <=> (deoxy)guanosine + orthophosphate [NP], Gallus gallus"
xref: Reactome:REACT_82860 "(deoxy)guanosine + orthophosphate <=> guanine + (deoxy)ribose 1-phosphate [NP], Canis familiaris"
xref: Reactome:REACT_83034 "(deoxy)inosine + orthophosphate <=> hypoxanthine + (deoxy)ribose 1-phosphate [NP], Sus scrofa"
xref: Reactome:REACT_83049 "(deoxy)guanosine + orthophosphate <=> guanine + (deoxy)ribose 1-phosphate [NP], Escherichia coli"
xref: Reactome:REACT_83680 "hypoxanthine + (deoxy)ribose 1-phosphate <=> (deoxy)inosine + orthophosphate [NP], Danio rerio"
xref: Reactome:REACT_83973 "guanine + (deoxy)ribose 1-phosphate <=> (deoxy)guanosine + orthophosphate [NP], Bos taurus"
xref: Reactome:REACT_84275 "hypoxanthine + (deoxy)ribose 1-phosphate <=> (deoxy)inosine + orthophosphate [NP], Saccharomyces cerevisiae"
xref: Reactome:REACT_84719 "hypoxanthine + (deoxy)ribose 1-phosphate <=> (deoxy)inosine + orthophosphate [NP], Rattus norvegicus"
xref: Reactome:REACT_85901 "guanine + (deoxy)ribose 1-phosphate <=> (deoxy)guanosine + orthophosphate [NP], Schizosaccharomyces pombe"
xref: Reactome:REACT_85952 "hypoxanthine + (deoxy)ribose 1-phosphate <=> (deoxy)inosine + orthophosphate [NP], Escherichia coli"
xref: Reactome:REACT_88195 "(deoxy)inosine + orthophosphate <=> hypoxanthine + (deoxy)ribose 1-phosphate [NP], Gallus gallus"
xref: Reactome:REACT_88493 "(deoxy)guanosine + orthophosphate <=> guanine + (deoxy)ribose 1-phosphate [NP], Danio rerio"
xref: Reactome:REACT_88807 "(deoxy)guanosine + orthophosphate <=> guanine + (deoxy)ribose 1-phosphate [NP], Gallus gallus"
xref: Reactome:REACT_90519 "guanine + (deoxy)ribose 1-phosphate <=> (deoxy)guanosine + orthophosphate [NP], Danio rerio"
xref: Reactome:REACT_92186 "guanine + (deoxy)ribose 1-phosphate <=> (deoxy)guanosine + orthophosphate [NP], Canis familiaris"
xref: Reactome:REACT_92775 "hypoxanthine + (deoxy)ribose 1-phosphate <=> (deoxy)inosine + orthophosphate [NP], Schizosaccharomyces pombe"
xref: Reactome:REACT_92835 "(deoxy)inosine + orthophosphate <=> hypoxanthine + (deoxy)ribose 1-phosphate [NP], Mus musculus"
xref: Reactome:REACT_93331 "(deoxy)inosine + orthophosphate <=> hypoxanthine + (deoxy)ribose 1-phosphate [NP], Danio rerio"
xref: Reactome:REACT_93793 "(deoxy)inosine + orthophosphate <=> hypoxanthine + (deoxy)ribose 1-phosphate [NP], Drosophila melanogaster"
xref: Reactome:REACT_93944 "(deoxy)guanosine + orthophosphate <=> guanine + (deoxy)ribose 1-phosphate [NP], Mycobacterium tuberculosis"
xref: Reactome:REACT_94051 "guanine + (deoxy)ribose 1-phosphate <=> (deoxy)guanosine + orthophosphate [NP], Caenorhabditis elegans"
xref: Reactome:REACT_94711 "hypoxanthine + (deoxy)ribose 1-phosphate <=> (deoxy)inosine + orthophosphate [NP], Taeniopygia guttata"
xref: Reactome:REACT_94783 "(deoxy)guanosine + orthophosphate <=> guanine + (deoxy)ribose 1-phosphate [NP], Mus musculus"
xref: Reactome:REACT_95751 "(deoxy)inosine + orthophosphate <=> hypoxanthine + (deoxy)ribose 1-phosphate [NP], Bos taurus"
xref: Reactome:REACT_95790 "hypoxanthine + (deoxy)ribose 1-phosphate <=> (deoxy)inosine + orthophosphate [NP], Xenopus tropicalis"
xref: Reactome:REACT_97359 "(deoxy)guanosine + orthophosphate <=> guanine + (deoxy)ribose 1-phosphate [NP], Rattus norvegicus"
xref: Reactome:REACT_97633 "guanine + (deoxy)ribose 1-phosphate <=> (deoxy)guanosine + orthophosphate [NP], Sus scrofa"
xref: Reactome:REACT_99029 "hypoxanthine + (deoxy)ribose 1-phosphate <=> (deoxy)inosine + orthophosphate [NP], Drosophila melanogaster"
xref: Reactome:REACT_99210 "(deoxy)inosine + orthophosphate <=> hypoxanthine + (deoxy)ribose 1-phosphate [NP], Mycobacterium tuberculosis"
xref: RHEA:19808
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0004732
name: pyridoxal oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyridoxal + H2O + O2 = 4-pyridoxate + hydrogen peroxide." [EC:1.2.3.8]
synonym: "pyridoxal:oxygen 4-oxidoreductase activity" EXACT [EC:1.2.3.8]
xref: EC:1.2.3.8
xref: MetaCyc:PYRIDOXAL-OXIDASE-RXN
xref: RHEA:23727
is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor

[Term]
id: GO:0004733
name: pyridoxamine-phosphate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH3 + hydrogen peroxide." [EC:1.4.3.5]
subset: gosubset_prok
synonym: "PdxH" RELATED [EC:1.4.3.5]
synonym: "PMP oxidase activity" EXACT [EC:1.4.3.5]
synonym: "pyridoxal 5'-phosphate synthase activity" EXACT [EC:1.4.3.5]
synonym: "pyridoxamine 5'-phosphate oxidase activity" EXACT [EC:1.4.3.5]
synonym: "pyridoxamine phosphate oxidase activity" EXACT [EC:1.4.3.5]
synonym: "pyridoxamine-5'-phosphate:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.5]
synonym: "pyridoxaminephosphate oxidase (EC 1.4.3.5: deaminating)" EXACT [EC:1.4.3.5]
synonym: "pyridoxine (pyridoxamine) 5'-phosphate oxidase activity" EXACT [EC:1.4.3.5]
synonym: "pyridoxine (pyridoxamine)phosphate oxidase activity" EXACT [EC:1.4.3.5]
synonym: "pyridoxol-5'-phosphate:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.5]
xref: EC:1.4.3.5
xref: MetaCyc:PMPOXI-RXN
xref: Reactome:REACT_25127 "PLP from oxidation of pyridoxamine phosphate, Homo sapiens"
xref: Reactome:REACT_25348 "PLP from oxidation of pyridoxine phosphate, Homo sapiens"
xref: RHEA:15820
is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
relationship: part_of GO:0042823 ! pyridoxal phosphate biosynthetic process

[Term]
id: GO:0004734
name: pyrimidodiazepine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: a pyrimidodiazepine + oxidized glutathione = 6-pyruvoyltetrahydropterin + 2 glutathione." [EC:1.5.4.1]
synonym: "PDA synthase activity" EXACT [EC:1.5.4.1]
synonym: "pyrimidodiazepine:glutathione-disulfide oxidoreductase (ring-opening, cyclizing)" EXACT [EC:1.5.4.1]
xref: EC:1.5.4.1
xref: MetaCyc:1.5.4.1-RXN
is_a: GO:0016648 ! oxidoreductase activity, acting on the CH-NH group of donors, disulfide as acceptor

[Term]
id: GO:0004735
name: pyrroline-5-carboxylate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+." [EC:1.5.1.2]
subset: gosubset_prok
synonym: "1-pyrroline-5-carboxylate reductase activity" EXACT [EC:1.5.1.2]
synonym: "L-proline oxidase activity" EXACT [EC:1.5.1.2]
synonym: "L-proline-NAD(P)+ 5-oxidoreductase activity" EXACT [EC:1.5.1.2]
synonym: "L-proline:NAD(P)+ 5-oxidoreductase activity" EXACT [EC:1.5.1.2]
synonym: "NADPH-L-delta1-pyrroline carboxylic acid reductase activity" EXACT [EC:1.5.1.2]
synonym: "P5CR activity" EXACT [EC:1.5.1.2]
xref: EC:1.5.1.2
xref: MetaCyc:PYRROLINECARBREDUCT-RXN
xref: Reactome:REACT_100008 "L-1-pyrroline-5-carboxylate + NADPH + H+ => proline + NADP+, Gallus gallus"
xref: Reactome:REACT_104986 "L-1-pyrroline-5-carboxylate + NADPH + H+ => proline + NADP+, Rattus norvegicus"
xref: Reactome:REACT_105265 "L-1-pyrroline-5-carboxylate + NADPH + H+ => proline + NADP+, Mus musculus"
xref: Reactome:REACT_107941 "L-1-pyrroline-5-carboxylate + NADPH + H+ => proline + NADP+, Danio rerio"
xref: Reactome:REACT_110281 "L-1-pyrroline-5-carboxylate + NADPH + H+ => proline + NADP+, Xenopus tropicalis"
xref: Reactome:REACT_110433 "L-1-pyrroline-5-carboxylate + NADPH + H+ => proline + NADP+, Canis familiaris"
xref: Reactome:REACT_113065 "L-1-pyrroline-5-carboxylate + NADPH + H+ => proline + NADP+, Oryza sativa"
xref: Reactome:REACT_113362 "L-1-pyrroline-5-carboxylate + NADPH + H+ => proline + NADP+, Arabidopsis thaliana"
xref: Reactome:REACT_113421 "L-1-pyrroline-5-carboxylate + NADPH + H+ => proline + NADP+, Plasmodium falciparum"
xref: Reactome:REACT_114311 "L-1-pyrroline-5-carboxylate + NADPH + H+ => proline + NADP+, Sus scrofa"
xref: Reactome:REACT_119 "L-1-pyrroline-5-carboxylate + NADPH + H+ => proline + NADP+, Homo sapiens"
xref: Reactome:REACT_95285 "L-1-pyrroline-5-carboxylate + NADPH + H+ => proline + NADP+, Bos taurus"
xref: Reactome:REACT_97457 "L-1-pyrroline-5-carboxylate + NADPH + H+ => proline + NADP+, Taeniopygia guttata"
xref: RHEA:14112
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004736
name: pyruvate carboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + bicarbonate + pyruvate = ADP + 2 H(+) + oxaloacetate + phosphate." [EC:6.4.1.1, RHEA:20847]
subset: gosubset_prok
synonym: "pyruvate:carbon-dioxide ligase (ADP-forming)" EXACT [EC:6.4.1.1]
synonym: "pyruvic carboxylase activity" EXACT [EC:6.4.1.1]
xref: EC:6.4.1.1
xref: KEGG:R00344
xref: MetaCyc:PYRUVATE-CARBOXYLASE-RXN
xref: Reactome:REACT_101213 "Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate, Arabidopsis thaliana"
xref: Reactome:REACT_102005 "Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate, Sus scrofa"
xref: Reactome:REACT_109289 "Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate, Escherichia coli"
xref: Reactome:REACT_115646 "pyruvate + CO2 + ATP => oxaloacetate + ADP + orthophosphate, Gallus gallus"
xref: Reactome:REACT_1895 "Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate, Homo sapiens"
xref: Reactome:REACT_32780 "Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate, Bos taurus"
xref: Reactome:REACT_34669 "Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate, Caenorhabditis elegans"
xref: Reactome:REACT_80156 "Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate, Xenopus tropicalis"
xref: Reactome:REACT_81680 "Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate, Canis familiaris"
xref: Reactome:REACT_81868 "Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate, Mycobacterium tuberculosis"
xref: Reactome:REACT_85488 "Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate, Staphylococcus aureus N315"
xref: Reactome:REACT_86468 "Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate, Rattus norvegicus"
xref: Reactome:REACT_87945 "Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate, Saccharomyces cerevisiae"
xref: Reactome:REACT_88939 "Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate, Schizosaccharomyces pombe"
xref: Reactome:REACT_88979 "Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate, Drosophila melanogaster"
xref: Reactome:REACT_97028 "Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate, Danio rerio"
xref: Reactome:REACT_97907 "Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate, Mus musculus"
xref: RHEA:20847
is_a: GO:0016885 ! ligase activity, forming carbon-carbon bonds

[Term]
id: GO:0004737
name: pyruvate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 2-oxo acid = an aldehyde + CO2." [EC:4.1.1.1]
subset: gosubset_prok
synonym: "2-oxo-acid carboxy-lyase (aldehyde-forming)" EXACT [EC:4.1.1.1]
synonym: "2-oxo-acid carboxy-lyase activity" EXACT [EC:4.1.1.1]
synonym: "alpha-carboxylase activity" EXACT [EC:4.1.1.1]
synonym: "alpha-ketoacid carboxylase activity" EXACT [EC:4.1.1.1]
synonym: "pyruvic decarboxylase activity" EXACT [EC:4.1.1.1]
xref: EC:4.1.1.1
xref: MetaCyc:PYRUVATE-DECARBOXYLASE-RXN
xref: RHEA:11631
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004738
name: pyruvate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the oxidative decarboxylation of pyruvate." [ISBN:0716020094]
subset: gosubset_prok
synonym: "pyruvic acid dehydrogenase activity" EXACT [EC:1.2.4.1]
synonym: "pyruvic dehydrogenase activity" EXACT [EC:1.2.4.1]
xref: MetaCyc:PYRUVOXID-RXN
xref: MetaCyc:RXN0-1134
xref: Reactome:REACT_100036 "pyruvate + CoASH + NAD+ => acetylCoA + CO2 + NADH + H+, Schizosaccharomyces pombe"
xref: Reactome:REACT_102216 "pyruvate + CoASH + NAD+ => acetylCoA + CO2 + NADH + H+, Xenopus tropicalis"
xref: Reactome:REACT_102641 "pyruvate + CoASH + NAD+ => acetylCoA + CO2 + NADH + H+, Arabidopsis thaliana"
xref: Reactome:REACT_108497 "pyruvate + CoASH + NAD+ => acetylCoA + CO2 + NADH + H+, Caenorhabditis elegans"
xref: Reactome:REACT_109621 "pyruvate + CoASH + NAD+ => acetylCoA + CO2 + NADH + H+, Mus musculus"
xref: Reactome:REACT_77363 "pyruvate + CoASH + NAD+ => acetylCoA + CO2 + NADH + H+, Taeniopygia guttata"
xref: Reactome:REACT_81144 "pyruvate + CoASH + NAD+ => acetylCoA + CO2 + NADH + H+, Gallus gallus"
xref: Reactome:REACT_85583 "pyruvate + CoASH + NAD+ => acetylCoA + CO2 + NADH + H+, Danio rerio"
xref: Reactome:REACT_88103 "pyruvate + CoASH + NAD+ => acetylCoA + CO2 + NADH + H+, Sus scrofa"
xref: Reactome:REACT_91141 "pyruvate + CoASH + NAD+ => acetylCoA + CO2 + NADH + H+, Dictyostelium discoideum"
xref: Reactome:REACT_93329 "pyruvate + CoASH + NAD+ => acetylCoA + CO2 + NADH + H+, Canis familiaris"
xref: Reactome:REACT_93801 "pyruvate + CoASH + NAD+ => acetylCoA + CO2 + NADH + H+, Bos taurus"
xref: Reactome:REACT_95829 "pyruvate + CoASH + NAD+ => acetylCoA + CO2 + NADH + H+, Saccharomyces cerevisiae"
xref: Reactome:REACT_96649 "pyruvate + CoASH + NAD+ => acetylCoA + CO2 + NADH + H+, Oryza sativa"
xref: Reactome:REACT_96724 "pyruvate + CoASH + NAD+ => acetylCoA + CO2 + NADH + H+, Rattus norvegicus"
xref: Reactome:REACT_983 "pyruvate + CoASH + NAD+ => acetylCoA + CO2 + NADH + H+, Homo sapiens"
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0004739
name: pyruvate dehydrogenase (acetyl-transferring) activity
namespace: molecular_function
def: "Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2." [EC:1.2.4.1]
subset: gosubset_prok
synonym: "MtPDC (mitochondrial pyruvate dehydogenase complex) activity" NARROW [EC:1.2.4.1]
synonym: "PDH" RELATED [EC:1.2.4.1]
synonym: "pyruvate dehydrogenase (lipoamide) activity" EXACT []
synonym: "pyruvate dehydrogenase complex activity" RELATED [EC:1.2.4.1]
synonym: "pyruvate:dihydrolipoyllysine-residue acetyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating)" EXACT [EC:1.2.4.1]
synonym: "pyruvate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-acetylating) activity" EXACT [EC:1.2.4.1]
xref: EC:1.2.4.1
is_a: GO:0004738 ! pyruvate dehydrogenase activity
is_a: GO:0016624 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor

[Term]
id: GO:0004740
name: pyruvate dehydrogenase (acetyl-transferring) kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + pyruvate dehydrogenase (acetyl-transferring) = ADP + pyruvate dehydrogenase (acetyl-transferring) phosphate." [EC:2.7.11.2]
synonym: "[pyruvate dehydrogenase (lipoamide)] kinase activity" EXACT []
synonym: "ATP:pyruvate dehydrogenase (acetyl-transferring) phosphotransferase activity" EXACT [EC:2.7.11.2]
synonym: "PDH kinase activity" EXACT [EC:2.7.11.2]
synonym: "PDHK" RELATED [EC:2.7.11.2]
synonym: "PDK" RELATED [EC:2.7.11.2]
synonym: "PDK1" RELATED [EC:2.7.11.2]
synonym: "PDK2" RELATED [EC:2.7.11.2]
synonym: "PDK3" RELATED [EC:2.7.11.2]
synonym: "PDK4" RELATED [EC:2.7.11.2]
synonym: "pyruvate dehydrogenase (lipoamide) kinase activity" EXACT []
synonym: "pyruvate dehydrogenase kinase (phosphorylating) activity" EXACT [EC:2.7.11.2]
synonym: "pyruvate dehydrogenase kinase activator protein activity" NARROW [EC:2.7.11.2]
synonym: "pyruvate dehydrogenase kinase activity" EXACT [EC:2.7.11.2]
synonym: "STK1" RELATED [EC:2.7.11.2]
xref: EC:2.7.11.2
xref: MetaCyc:2.7.11.2-RXN
xref: Reactome:REACT_103828 "PDK-catalyzed phosphorylation (inactivation) of PDC E1 alpha subunit, Canis familiaris"
xref: Reactome:REACT_108288 "PDK-catalyzed phosphorylation (inactivation) of PDC E1 alpha subunit, Xenopus tropicalis"
xref: Reactome:REACT_12462 "PDK-catalyzed phosphorylation (inactivation) of PDC E1 alpha subunit, Homo sapiens"
xref: Reactome:REACT_32602 "PDK-catalyzed phosphorylation (inactivation) of PDC E1 alpha subunit, Bos taurus"
xref: Reactome:REACT_59908 "PDK-catalyzed phosphorylation (inactivation) of PDC E1 alpha subunit, Mus musculus"
xref: Reactome:REACT_77760 "PDK-catalyzed phosphorylation (inactivation) of PDC E1 alpha subunit, Gallus gallus"
xref: Reactome:REACT_79111 "PDK-catalyzed phosphorylation (inactivation) of PDC E1 alpha subunit, Rattus norvegicus"
xref: Reactome:REACT_86790 "PDK-catalyzed phosphorylation (inactivation) of PDC E1 alpha subunit, Danio rerio"
xref: Reactome:REACT_91743 "PDK-catalyzed phosphorylation (inactivation) of PDC E1 alpha subunit, Caenorhabditis elegans"
xref: Reactome:REACT_93375 "PDK-catalyzed phosphorylation (inactivation) of PDC E1 alpha subunit, Sus scrofa"
xref: Reactome:REACT_93861 "PDK-catalyzed phosphorylation (inactivation) of PDC E1 alpha subunit, Taeniopygia guttata"
is_a: GO:0004672 ! protein kinase activity

[Term]
id: GO:0004741
name: [pyruvate dehydrogenase (lipoamide)] phosphatase activity
namespace: molecular_function
alt_id: GO:0019906
def: "Catalysis of the reaction: [pyruvate dehydrogenase (lipoamide)] phosphate + H2O = [pyruvate dehydrogenase (lipoamide)] + phosphate." [EC:3.1.3.43]
synonym: "[pyruvate dehydrogenase (lipoamide)] phosphatase, intrinsic catalyst activity" EXACT []
synonym: "phosphopyruvate dehydrogenase phosphatase activity" EXACT [EC:3.1.3.43]
synonym: "pyruvate dehydrogenase (lipoamide) phosphatase activity" EXACT []
synonym: "pyruvate dehydrogenase (lipoamide)-phosphatase activity" EXACT [EC:3.1.3.43]
synonym: "pyruvate dehydrogenase (lipoamide)-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.43]
synonym: "pyruvate dehydrogenase phosphatase activity" EXACT [EC:3.1.3.43]
xref: EC:3.1.3.43
xref: MetaCyc:3.1.3.43-RXN
xref: Reactome:REACT_100007 "PDP-catalyzed dephosphorylation (activation) of phospho E1 alpha subunit, Canis familiaris"
xref: Reactome:REACT_101157 "PDP-catalyzed dephosphorylation (activation) of phospho E1 alpha subunit, Xenopus tropicalis"
xref: Reactome:REACT_101860 "PDP-catalyzed dephosphorylation (activation) of phospho E1 alpha subunit, Caenorhabditis elegans"
xref: Reactome:REACT_105428 "PDP-catalyzed dephosphorylation (activation) of phospho E1 alpha subunit, Danio rerio"
xref: Reactome:REACT_107012 "PDP-catalyzed dephosphorylation (activation) of phospho E1 alpha subunit, Bos taurus"
xref: Reactome:REACT_12543 "PDP-catalyzed dephosphorylation (activation) of phospho E1 alpha subunit, Homo sapiens"
xref: Reactome:REACT_82386 "PDP-catalyzed dephosphorylation (activation) of phospho E1 alpha subunit, Sus scrofa"
xref: Reactome:REACT_85168 "PDP-catalyzed dephosphorylation (activation) of phospho E1 alpha subunit, Gallus gallus"
xref: Reactome:REACT_96046 "PDP-catalyzed dephosphorylation (activation) of phospho E1 alpha subunit, Mus musculus"
xref: Reactome:REACT_96198 "PDP-catalyzed dephosphorylation (activation) of phospho E1 alpha subunit, Taeniopygia guttata"
xref: Reactome:REACT_96511 "PDP-catalyzed dephosphorylation (activation) of phospho E1 alpha subunit, Rattus norvegicus"
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0004742
name: dihydrolipoyllysine-residue acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + dihydrolipoamide = CoA + S-acetyldihydrolipoamide." [EC:2.3.1.12]
subset: gosubset_prok
synonym: "acetyl-CoA: enzyme-6-N-(dihydrolipoyl)lysine S-acetyltransferase activity" EXACT [EC:2.3.1.12]
synonym: "acetyl-CoA: enzyme-N6-(dihydrolipoyl)lysine S-acetyltransferase activity" EXACT [EC:2.3.1.12]
synonym: "acetyl-CoA:dihydrolipoamide S-acetyltransferase activity" EXACT [EC:2.3.1.12]
synonym: "dihydrolipoamide S-acetyltransferase activity" EXACT []
synonym: "dihydrolipoate acetyltransferase activity" EXACT [EC:2.3.1.12]
synonym: "dihydrolipoic transacetylase activity" EXACT [EC:2.3.1.12]
synonym: "dihydrolipoyl acetyltransferase activity" EXACT [EC:2.3.1.12]
synonym: "enzyme-dihydrolipoyllysine:acetyl-CoA S-acetyltransferase activity" EXACT [EC:2.3.1.12]
synonym: "lipoate acetyltransferase activity" EXACT [EC:2.3.1.12]
synonym: "lipoate transacetylase activity" EXACT [EC:2.3.1.12]
synonym: "lipoic acetyltransferase activity" EXACT [EC:2.3.1.12]
synonym: "lipoic acid acetyltransferase activity" EXACT [EC:2.3.1.12]
synonym: "lipoic transacetylase activity" EXACT [EC:2.3.1.12]
synonym: "lipoylacetyltransferase activity" EXACT [EC:2.3.1.12]
synonym: "thioltransacetylase A activity" NARROW [EC:2.3.1.12]
synonym: "transacetylase X activity" NARROW [EC:2.3.1.12]
xref: EC:2.3.1.12
is_a: GO:0016418 ! S-acetyltransferase activity
is_a: GO:0030523 ! dihydrolipoamide S-acyltransferase activity

[Term]
id: GO:0004743
name: pyruvate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate." [EC:2.7.1.40]
subset: gosubset_prok
synonym: "ATP:pyruvate 2-O-phosphotransferase activity" EXACT [EC:2.7.1.40]
synonym: "phosphoenol transphosphorylase activity" EXACT [EC:2.7.1.40]
synonym: "phosphoenolpyruvate kinase activity" EXACT [EC:2.7.1.40]
xref: EC:2.7.1.40
xref: MetaCyc:PEPDEPHOS-RXN
xref: Reactome:REACT_101257 "phosphoenolpyruvate + ADP => pyruvate + ATP, Saccharomyces cerevisiae"
xref: Reactome:REACT_101740 "phosphoenolpyruvate + ADP => pyruvate + ATP, Mus musculus"
xref: Reactome:REACT_107647 "phosphoenolpyruvate + ADP => pyruvate + ATP, Schizosaccharomyces pombe"
xref: Reactome:REACT_109252 "phosphoenolpyruvate + ADP => pyruvate + ATP, Canis familiaris"
xref: Reactome:REACT_112705 "phosphoenolpyruvate + ADP => pyruvate + ATP, Oryza sativa"
xref: Reactome:REACT_114095 "phosphoenolpyruvate + ADP => pyruvate + ATP, Arabidopsis thaliana"
xref: Reactome:REACT_114481 "phosphoenolpyruvate + ADP => pyruvate + ATP, Plasmodium falciparum"
xref: Reactome:REACT_115607 "phosphoenolpyruvate + ADP => pyruvate + ATP, Gallus gallus"
xref: Reactome:REACT_1524 "phosphoenolpyruvate + ADP => pyruvate + ATP, Homo sapiens"
xref: Reactome:REACT_30287 "phosphoenolpyruvate + ADP => pyruvate + ATP, Danio rerio"
xref: Reactome:REACT_32324 "phosphoenolpyruvate + ADP => pyruvate + ATP, Bos taurus"
xref: Reactome:REACT_78511 "phosphoenolpyruvate + ADP => pyruvate + ATP, Taeniopygia guttata"
xref: Reactome:REACT_78996 "phosphoenolpyruvate + ADP => pyruvate + ATP, Xenopus tropicalis"
xref: Reactome:REACT_81895 "phosphoenolpyruvate + ADP => pyruvate + ATP, Rattus norvegicus"
xref: Reactome:REACT_85253 "phosphoenolpyruvate + ADP => pyruvate + ATP, Dictyostelium discoideum"
xref: Reactome:REACT_88726 "phosphoenolpyruvate + ADP => pyruvate + ATP, Gallus gallus"
xref: Reactome:REACT_89006 "phosphoenolpyruvate + ADP => pyruvate + ATP, Staphylococcus aureus N315"
xref: Reactome:REACT_91947 "phosphoenolpyruvate + ADP => pyruvate + ATP, Sus scrofa"
xref: Reactome:REACT_99833 "phosphoenolpyruvate + ADP => pyruvate + ATP, Escherichia coli"
xref: RHEA:18160
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
relationship: part_of GO:0006096 ! glycolytic process

[Term]
id: GO:0004744
name: retinal isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: all-trans-retinal = 11-cis-retinal." [RHEA:24127]
synonym: "all-trans-retinal 11-cis-trans-isomerase activity" EXACT [EC:5.2.1.3]
synonym: "retinene isomerase activity" RELATED [EC:5.2.1.3]
synonym: "retinoid isomerase activity" BROAD [EC:5.2.1.3]
xref: KEGG:R02126
xref: MetaCyc:RETINAL-ISOMERASE-RXN
xref: RHEA:24127
is_a: GO:0016859 ! cis-trans isomerase activity

[Term]
id: GO:0004745
name: retinol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+." [EC:1.1.1.105]
subset: gosubset_prok
synonym: "all-trans retinol dehydrogenase activity" BROAD [EC:1.1.1.105]
synonym: "MDR" RELATED [EC:1.1.1.105]
synonym: "microsomal retinol dehydrogenase activity" BROAD [EC:1.1.1.105]
synonym: "retinal reductase activity" BROAD [GOC:ecd, PMID:12036956]
synonym: "retinene reductase activity" BROAD [EC:1.1.1.105]
synonym: "retinol (vitamin A1) dehydrogenase activity" BROAD [EC:1.1.1.105]
synonym: "retinol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.105]
xref: EC:1.1.1.105
xref: MetaCyc:RETINOL-DEHYDROGENASE-RXN
xref: RHEA:21287
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004746
name: riboflavin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) = 5-amino-6-(D-ribitylamino)uracil + riboflavin." [EC:2.5.1.9, RHEA:20775]
subset: gosubset_prok
synonym: "6,7-dimethyl-8-(1-D-ribityl)lumazine:6,7-dimethyl-8-(1-D-ribityl)lumazine 2,3-butanediyltransferase activity" EXACT [EC:2.5.1.9]
synonym: "heavy riboflavin synthase" NARROW [EC:2.5.1.9]
synonym: "light riboflavin synthase" NARROW [EC:2.5.1.9]
synonym: "lumazine synthase activity" BROAD [BRENDA:2.5.1.9]
synonym: "riboflavin synthetase activity" EXACT [EC:2.5.1.9]
synonym: "riboflavine synthase activity" EXACT [EC:2.5.1.9]
synonym: "riboflavine synthetase activity" EXACT [EC:2.5.1.9]
synonym: "vitamin B2 synthase activity" EXACT []
xref: EC:2.5.1.9
xref: KEGG:R00066
xref: MetaCyc:RIBOFLAVIN-SYN-RXN
xref: RHEA:20775
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0004747
name: ribokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate." [EC:2.7.1.15]
subset: gosubset_prok
synonym: "ATP:D-ribose 5-phosphotransferase activity" EXACT [EC:2.7.1.15]
synonym: "D-ribokinase activity" EXACT [EC:2.7.1.15]
synonym: "deoxyribokinase activity" EXACT [EC:2.7.1.15]
synonym: "ribokinase (phosphorylating)" EXACT [EC:2.7.1.15]
xref: EC:2.7.1.15
xref: MetaCyc:RIBOKIN-RXN
xref: RHEA:13700
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0004748
name: ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
namespace: molecular_function
alt_id: GO:0016959
alt_id: GO:0016960
alt_id: GO:0016961
def: "Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.17.4.1]
comment: When thioredoxin is substituted for glutaredoxin in the reaction, annotate instead to 'ribonucleoside-diphosphate reductase, glutaredoxin disulfide as acceptor ; GO:0036175'.
subset: gosubset_prok
synonym: "2'-deoxyribonucleoside-diphosphate:oxidized-thioredoxin 2'-oxidoreductase activity" EXACT [EC:1.17.4.1]
synonym: "2'-deoxyribonucleoside-diphosphate:thioredoxin-disulfide 2'-oxidoreductase activity" EXACT [EC:1.17.4.1]
xref: EC:1.17.4.1
xref: MetaCyc:RIBONUCLEOSIDE-DIP-REDUCTI-RXN
xref: Reactome:REACT_100706 "NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O, Xenopus tropicalis"
xref: Reactome:REACT_101277 "NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O, Mus musculus"
xref: Reactome:REACT_104003 "NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O, Gallus gallus"
xref: Reactome:REACT_108099 "NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O, Gallus gallus"
xref: Reactome:REACT_113565 "NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O, Caenorhabditis elegans"
xref: Reactome:REACT_115326 "NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O, Caenorhabditis elegans"
xref: Reactome:REACT_2182 "NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O, Homo sapiens"
xref: Reactome:REACT_29224 "NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O, Sus scrofa"
xref: Reactome:REACT_30318 "NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O, Taeniopygia guttata"
xref: Reactome:REACT_31478 "NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O, Canis familiaris"
xref: Reactome:REACT_33931 "NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O, Danio rerio"
xref: Reactome:REACT_34006 "NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O, Bos taurus"
xref: Reactome:REACT_642 "NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O, Homo sapiens"
xref: Reactome:REACT_79772 "NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O, Mus musculus"
xref: Reactome:REACT_81191 "NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O, Bos taurus"
xref: Reactome:REACT_86582 "NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O, Xenopus tropicalis"
xref: Reactome:REACT_91454 "NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O, Canis familiaris"
xref: Reactome:REACT_94107 "NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O, Taeniopygia guttata"
xref: Reactome:REACT_98694 "NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O, Danio rerio"
xref: RHEA:23255
is_a: GO:0061731 ! ribonucleoside-diphosphate reductase activity

[Term]
id: GO:0004749
name: ribose phosphate diphosphokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + 2 H(+)." [EC:2.7.6.1, RHEA:15612]
subset: gosubset_prok
synonym: "5-phosphoribose pyrophosphorylase activity" EXACT [EC:2.7.6.1]
synonym: "5-phosphoribosyl-1-pyrophosphate synthetase activity" EXACT [EC:2.7.6.1]
synonym: "5-phosphoribosyl-alpha-1-pyrophosphate synthetase activity" EXACT [EC:2.7.6.1]
synonym: "ATP:D-ribose-5-phosphate diphosphotransferase activity" EXACT [EC:2.7.6.1]
synonym: "phosphoribosyl diphosphate synthetase activity" EXACT [EC:2.7.6.1]
synonym: "phosphoribosyl pyrophosphate synthetase activity" EXACT [EC:2.7.6.1]
synonym: "phosphoribosyl-diphosphate synthetase activity" EXACT [EC:2.7.6.1]
synonym: "phosphoribosylpyrophosphate synthase activity" EXACT [EC:2.7.6.1]
synonym: "phosphoribosylpyrophosphate synthetase activity" EXACT [EC:2.7.6.1]
synonym: "PP-ribose P synthetase activity" EXACT [EC:2.7.6.1]
synonym: "PPRibP synthetase activity" EXACT [EC:2.7.6.1]
synonym: "PRPP synthetase activity" EXACT [EC:2.7.6.1]
synonym: "pyrophosphoribosylphosphate synthetase activity" EXACT [EC:2.7.6.1]
synonym: "ribophosphate pyrophosphokinase activity" EXACT [EC:2.7.6.1]
synonym: "ribose-5-phosphate pyrophosphokinase activity" EXACT [EC:2.7.6.1]
synonym: "ribose-phosphate diphosphokinase activity" EXACT [EC:2.7.6.1]
synonym: "ribose-phosphate pyrophosphokinase activity" EXACT []
xref: EC:2.7.6.1
xref: KEGG:R01049
xref: MetaCyc:PRPPSYN-RXN
xref: MetaCyc:PWY0-662
xref: Reactome:REACT_101576 "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_102931 "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate, Rattus norvegicus"
xref: Reactome:REACT_103255 "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate, Danio rerio"
xref: Reactome:REACT_103562 "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate, Plasmodium falciparum"
xref: Reactome:REACT_104125 "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate, Drosophila melanogaster"
xref: Reactome:REACT_105778 "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate, Canis familiaris"
xref: Reactome:REACT_105917 "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate, Staphylococcus aureus N315"
xref: Reactome:REACT_106207 "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate, Mycobacterium tuberculosis"
xref: Reactome:REACT_106619 "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate, Arabidopsis thaliana"
xref: Reactome:REACT_108707 "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate, Gallus gallus"
xref: Reactome:REACT_108857 "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_110519 "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate, Mus musculus"
xref: Reactome:REACT_113259 "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate, Xenopus tropicalis"
xref: Reactome:REACT_114942 "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate, Xenopus tropicalis"
xref: Reactome:REACT_1781 "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate, Homo sapiens"
xref: Reactome:REACT_2023 "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate, Homo sapiens"
xref: Reactome:REACT_28961 "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate, Mycobacterium tuberculosis"
xref: Reactome:REACT_29384 "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate, Arabidopsis thaliana"
xref: Reactome:REACT_31823 "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate, Bos taurus"
xref: Reactome:REACT_31992 "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate, Oryza sativa"
xref: Reactome:REACT_33660 "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate, Escherichia coli"
xref: Reactome:REACT_34206 "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate, Plasmodium falciparum"
xref: Reactome:REACT_77804 "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate, Sus scrofa"
xref: Reactome:REACT_83080 "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_83446 "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate, Caenorhabditis elegans"
xref: Reactome:REACT_84616 "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_86325 "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate, Rattus norvegicus"
xref: Reactome:REACT_86893 "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate, Staphylococcus aureus N315"
xref: Reactome:REACT_87941 "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate, Bos taurus"
xref: Reactome:REACT_91855 "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate, Danio rerio"
xref: Reactome:REACT_93127 "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate, Mus musculus"
xref: Reactome:REACT_93559 "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate, Drosophila melanogaster"
xref: Reactome:REACT_94335 "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate, Caenorhabditis elegans"
xref: Reactome:REACT_94569 "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate, Sus scrofa"
xref: Reactome:REACT_94862 "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate, Gallus gallus"
xref: Reactome:REACT_95019 "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate, Escherichia coli"
xref: Reactome:REACT_95773 "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_95781 "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_97038 "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate, Canis familiaris"
xref: Reactome:REACT_99491 "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate, Oryza sativa"
xref: RHEA:15612
is_a: GO:0016778 ! diphosphotransferase activity

[Term]
id: GO:0004750
name: ribulose-phosphate 3-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-ribulose 5-phosphate = D-xylulose 5-phosphate." [EC:5.1.3.1, RHEA:13680]
subset: gosubset_prok
synonym: "D-ribulose 5-phosphate epimerase activity" EXACT [EC:5.1.3.1]
synonym: "D-ribulose phosphate-3-epimerase activity" EXACT [EC:5.1.3.1]
synonym: "D-ribulose-5-P 3-epimerase activity" EXACT [EC:5.1.3.1]
synonym: "D-ribulose-5-phosphate 3-epimerase activity" EXACT [EC:5.1.3.1]
synonym: "D-ribulose-5-phosphate epimerase activity" EXACT [EC:5.1.3.1]
synonym: "D-xylulose-5-phosphate 3-epimerase activity" EXACT [EC:5.1.3.1]
synonym: "erythrose-4-phosphate epimerase activity" EXACT [EC:5.1.3.1]
synonym: "erythrose-4-phosphate isomerase activity" EXACT [EC:5.1.3.1]
synonym: "pentose-5-phosphate 3-epimerase activity" EXACT [EC:5.1.3.1]
synonym: "phosphoketopentose 3-epimerase activity" EXACT [EC:5.1.3.1]
synonym: "phosphoketopentose epimerase activity" EXACT [EC:5.1.3.1]
synonym: "phosphoribulose epimerase activity" EXACT [EC:5.1.3.1]
synonym: "ribulose 5-phosphate 3-epimerase activity" EXACT [EC:5.1.3.1]
synonym: "xylulose phosphate 3-epimerase activity" EXACT [EC:5.1.3.1]
xref: EC:5.1.3.1
xref: KEGG:R01529
xref: MetaCyc:RIBULP3EPIM-RXN
xref: Reactome:REACT_100824 "xylulose 5-phosphate <=> D-ribulose 5-phosphate, Drosophila melanogaster"
xref: Reactome:REACT_101588 "D-ribulose 5-phosphate <=> xylulose 5-phosphate, Escherichia coli"
xref: Reactome:REACT_102631 "D-ribulose 5-phosphate <=> xylulose 5-phosphate, Drosophila melanogaster"
xref: Reactome:REACT_103322 "D-ribulose 5-phosphate <=> xylulose 5-phosphate, Canis familiaris"
xref: Reactome:REACT_103433 "xylulose 5-phosphate <=> D-ribulose 5-phosphate, Gallus gallus"
xref: Reactome:REACT_104995 "xylulose 5-phosphate <=> D-ribulose 5-phosphate, Plasmodium falciparum"
xref: Reactome:REACT_106480 "D-ribulose 5-phosphate <=> xylulose 5-phosphate, Dictyostelium discoideum"
xref: Reactome:REACT_106848 "xylulose 5-phosphate <=> D-ribulose 5-phosphate, Xenopus tropicalis"
xref: Reactome:REACT_106905 "D-ribulose 5-phosphate <=> xylulose 5-phosphate, Rattus norvegicus"
xref: Reactome:REACT_109378 "D-ribulose 5-phosphate <=> xylulose 5-phosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_109649 "xylulose 5-phosphate <=> D-ribulose 5-phosphate, Caenorhabditis elegans"
xref: Reactome:REACT_109963 "xylulose 5-phosphate <=> D-ribulose 5-phosphate, Canis familiaris"
xref: Reactome:REACT_11118 "xylulose 5-phosphate <=> D-ribulose 5-phosphate, Homo sapiens"
xref: Reactome:REACT_113659 "D-ribulose 5-phosphate <=> xylulose 5-phosphate, Sus scrofa"
xref: Reactome:REACT_114208 "xylulose 5-phosphate <=> D-ribulose 5-phosphate, Sus scrofa"
xref: Reactome:REACT_1522 "D-ribulose 5-phosphate <=> xylulose 5-phosphate, Homo sapiens"
xref: Reactome:REACT_30648 "xylulose 5-phosphate <=> D-ribulose 5-phosphate, Staphylococcus aureus N315"
xref: Reactome:REACT_30976 "xylulose 5-phosphate <=> D-ribulose 5-phosphate, Escherichia coli"
xref: Reactome:REACT_31729 "xylulose 5-phosphate <=> D-ribulose 5-phosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_32935 "xylulose 5-phosphate <=> D-ribulose 5-phosphate, Mus musculus"
xref: Reactome:REACT_33612 "D-ribulose 5-phosphate <=> xylulose 5-phosphate, Arabidopsis thaliana"
xref: Reactome:REACT_35802 "xylulose 5-phosphate <=> D-ribulose 5-phosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_77356 "xylulose 5-phosphate <=> D-ribulose 5-phosphate, Dictyostelium discoideum"
xref: Reactome:REACT_77718 "D-ribulose 5-phosphate <=> xylulose 5-phosphate, Plasmodium falciparum"
xref: Reactome:REACT_80876 "xylulose 5-phosphate <=> D-ribulose 5-phosphate, Mycobacterium tuberculosis"
xref: Reactome:REACT_81479 "D-ribulose 5-phosphate <=> xylulose 5-phosphate, Mus musculus"
xref: Reactome:REACT_82433 "xylulose 5-phosphate <=> D-ribulose 5-phosphate, Rattus norvegicus"
xref: Reactome:REACT_82797 "D-ribulose 5-phosphate <=> xylulose 5-phosphate, Taeniopygia guttata"
xref: Reactome:REACT_84270 "xylulose 5-phosphate <=> D-ribulose 5-phosphate, Taeniopygia guttata"
xref: Reactome:REACT_85771 "xylulose 5-phosphate <=> D-ribulose 5-phosphate, Oryza sativa"
xref: Reactome:REACT_88833 "D-ribulose 5-phosphate <=> xylulose 5-phosphate, Mycobacterium tuberculosis"
xref: Reactome:REACT_90885 "xylulose 5-phosphate <=> D-ribulose 5-phosphate, Arabidopsis thaliana"
xref: Reactome:REACT_93195 "D-ribulose 5-phosphate <=> xylulose 5-phosphate, Xenopus tropicalis"
xref: Reactome:REACT_93209 "D-ribulose 5-phosphate <=> xylulose 5-phosphate, Staphylococcus aureus N315"
xref: Reactome:REACT_93241 "D-ribulose 5-phosphate <=> xylulose 5-phosphate, Gallus gallus"
xref: Reactome:REACT_93310 "D-ribulose 5-phosphate <=> xylulose 5-phosphate, Oryza sativa"
xref: Reactome:REACT_96012 "D-ribulose 5-phosphate <=> xylulose 5-phosphate, Caenorhabditis elegans"
xref: Reactome:REACT_97480 "xylulose 5-phosphate <=> D-ribulose 5-phosphate, Danio rerio"
xref: Reactome:REACT_97663 "D-ribulose 5-phosphate <=> xylulose 5-phosphate, Danio rerio"
xref: Reactome:REACT_97858 "D-ribulose 5-phosphate <=> xylulose 5-phosphate, Schizosaccharomyces pombe"
xref: RHEA:13680
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0004751
name: ribose-5-phosphate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-ribose 5-phosphate = D-ribulose 5-phosphate." [EC:5.3.1.6, RHEA:14660]
subset: gosubset_prok
synonym: "5-phosphoribose isomerase activity" EXACT [EC:5.3.1.6]
synonym: "D-ribose 5-phosphate isomerase activity" EXACT [EC:5.3.1.6]
synonym: "D-ribose-5-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.6]
synonym: "D-ribose-5-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.6]
synonym: "phosphopentoseisomerase activity" EXACT [EC:5.3.1.6]
synonym: "phosphopentosisomerase activity" EXACT [EC:5.3.1.6]
synonym: "phosphoriboisomerase activity" EXACT [EC:5.3.1.6]
synonym: "ribose 5-phosphate epimerase activity" EXACT [EC:5.3.1.6]
synonym: "ribose phosphate isomerase activity" EXACT [EC:5.3.1.6]
xref: EC:5.3.1.6
xref: KEGG:R01056
xref: MetaCyc:RIB5PISOM-RXN
xref: Reactome:REACT_100811 "D-ribulose 5-phosphate <=> ribose 5-phosphate, Danio rerio"
xref: Reactome:REACT_101422 "D-ribulose 5-phosphate <=> ribose 5-phosphate, Bos taurus"
xref: Reactome:REACT_102385 "D-ribulose 5-phosphate <=> ribose 5-phosphate, Staphylococcus aureus N315"
xref: Reactome:REACT_103258 "D-ribulose 5-phosphate <=> ribose 5-phosphate, Drosophila melanogaster"
xref: Reactome:REACT_104652 "ribose 5-phosphate <=> D-ribulose 5-phosphate, Sus scrofa"
xref: Reactome:REACT_104980 "ribose 5-phosphate <=> D-ribulose 5-phosphate, Canis familiaris"
xref: Reactome:REACT_106778 "ribose 5-phosphate <=> D-ribulose 5-phosphate, Mus musculus"
xref: Reactome:REACT_107958 "ribose 5-phosphate <=> D-ribulose 5-phosphate, Rattus norvegicus"
xref: Reactome:REACT_108490 "ribose 5-phosphate <=> D-ribulose 5-phosphate, Drosophila melanogaster"
xref: Reactome:REACT_113206 "D-ribulose 5-phosphate <=> ribose 5-phosphate, Arabidopsis thaliana"
xref: Reactome:REACT_114043 "ribose 5-phosphate <=> D-ribulose 5-phosphate, Oryza sativa"
xref: Reactome:REACT_115286 "ribose 5-phosphate <=> D-ribulose 5-phosphate, Arabidopsis thaliana"
xref: Reactome:REACT_115365 "D-ribulose 5-phosphate <=> ribose 5-phosphate, Oryza sativa"
xref: Reactome:REACT_2033 "D-ribulose 5-phosphate <=> ribose 5-phosphate, Homo sapiens"
xref: Reactome:REACT_28276 "D-ribulose 5-phosphate <=> ribose 5-phosphate, Canis familiaris"
xref: Reactome:REACT_28429 "ribose 5-phosphate <=> D-ribulose 5-phosphate, Plasmodium falciparum"
xref: Reactome:REACT_29756 "D-ribulose 5-phosphate <=> ribose 5-phosphate, Dictyostelium discoideum"
xref: Reactome:REACT_31507 "ribose 5-phosphate <=> D-ribulose 5-phosphate, Caenorhabditis elegans"
xref: Reactome:REACT_32979 "ribose 5-phosphate <=> D-ribulose 5-phosphate, Taeniopygia guttata"
xref: Reactome:REACT_33178 "ribose 5-phosphate <=> D-ribulose 5-phosphate, Gallus gallus"
xref: Reactome:REACT_33224 "ribose 5-phosphate <=> D-ribulose 5-phosphate, Staphylococcus aureus N315"
xref: Reactome:REACT_34759 "D-ribulose 5-phosphate <=> ribose 5-phosphate, Plasmodium falciparum"
xref: Reactome:REACT_6907 "ribose 5-phosphate <=> D-ribulose 5-phosphate, Homo sapiens"
xref: Reactome:REACT_78002 "ribose 5-phosphate <=> D-ribulose 5-phosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_78156 "ribose 5-phosphate <=> D-ribulose 5-phosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_78609 "D-ribulose 5-phosphate <=> ribose 5-phosphate, Taeniopygia guttata"
xref: Reactome:REACT_78629 "D-ribulose 5-phosphate <=> ribose 5-phosphate, Xenopus tropicalis"
xref: Reactome:REACT_83201 "D-ribulose 5-phosphate <=> ribose 5-phosphate, Rattus norvegicus"
xref: Reactome:REACT_85011 "ribose 5-phosphate <=> D-ribulose 5-phosphate, Xenopus tropicalis"
xref: Reactome:REACT_87468 "D-ribulose 5-phosphate <=> ribose 5-phosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_88021 "D-ribulose 5-phosphate <=> ribose 5-phosphate, Caenorhabditis elegans"
xref: Reactome:REACT_90331 "D-ribulose 5-phosphate <=> ribose 5-phosphate, Gallus gallus"
xref: Reactome:REACT_91770 "D-ribulose 5-phosphate <=> ribose 5-phosphate, Mus musculus"
xref: Reactome:REACT_92223 "D-ribulose 5-phosphate <=> ribose 5-phosphate, Escherichia coli"
xref: Reactome:REACT_96734 "ribose 5-phosphate <=> D-ribulose 5-phosphate, Escherichia coli"
xref: Reactome:REACT_97398 "ribose 5-phosphate <=> D-ribulose 5-phosphate, Danio rerio"
xref: Reactome:REACT_98105 "D-ribulose 5-phosphate <=> ribose 5-phosphate, Sus scrofa"
xref: Reactome:REACT_98383 "D-ribulose 5-phosphate <=> ribose 5-phosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_98700 "ribose 5-phosphate <=> D-ribulose 5-phosphate, Dictyostelium discoideum"
xref: Reactome:REACT_99383 "ribose 5-phosphate <=> D-ribulose 5-phosphate, Bos taurus"
xref: RHEA:14660
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0004753
name: saccharopine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the cleavage of N6-(L-1,3-dicarboxypropyl)-L-lysine to release an amino acid (lysine or glutamate), with the concomitant reduction of an electron acceptor." [GOC:mah]
subset: gosubset_prok
synonym: "lysine-2-oxoglutarate reductase activity" EXACT [EC:1.5.1.-]
synonym: "lysine-ketoglutarate reductase activity" EXACT [EC:1.5.1.-]
xref: EC:1.5.1.-
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004754
name: saccharopine dehydrogenase (NAD+, L-lysine-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: L-saccharopine + H(2)O + NAD(+) = 2-oxoglutarate + L-lysine + H(+) + NADH." [EC:1.5.1.7, RHEA:12443]
subset: gosubset_prok
synonym: "6-N-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming)" EXACT [EC:1.5.1.7]
synonym: "dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, lysine forming)" EXACT [EC:1.5.1.7]
synonym: "epsilon-N-(L-glutaryl-2)-L-lysine:NAD oxidoreductase (L-lysine forming)" EXACT [EC:1.5.1.7]
synonym: "N6-(glutar-2-yl)-L-lysine:NAD oxidoreductase (L-lysine-forming)" EXACT [EC:1.5.1.7]
synonym: "N6-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming)" EXACT [EC:1.5.1.7]
xref: EC:1.5.1.7
xref: KEGG:R00715
xref: MetaCyc:1.5.1.7-RXN
xref: RHEA:12443
is_a: GO:0004753 ! saccharopine dehydrogenase activity

[Term]
id: GO:0004755
name: saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: L-saccharopine + H(2)O + NADP(+) = L-allysine + L-glutamate + H(+) + NADPH." [EC:1.5.1.10, RHEA:10023]
subset: gosubset_prok
synonym: "6-N-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-glutamate-forming)" EXACT [EC:1.5.1.10]
synonym: "aminoadipate semialdehyde-glutamate reductase activity" EXACT [EC:1.5.1.10]
synonym: "aminoadipic semialdehyde-glutamate reductase activity" EXACT [EC:1.5.1.10]
synonym: "aminoadipic semialdehyde-glutamic reductase activity" EXACT [EC:1.5.1.10]
synonym: "epsilon-N-(L-glutaryl-2)-L-lysine:NAD+(P) oxidoreductase (L-2-aminoadipate-semialdehyde forming)" EXACT [EC:1.5.1.10]
synonym: "N6-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-glutamate-forming)" EXACT [EC:1.5.1.10]
synonym: "saccharopine (nicotinamide adenine dinucleotide phosphate, glutamate-forming) dehydrogenase activity" EXACT [EC:1.5.1.10]
synonym: "saccharopine reductase activity" EXACT [EC:1.5.1.10]
xref: EC:1.5.1.10
xref: KEGG:R02315
xref: MetaCyc:RXN3O-127
xref: RHEA:10023
is_a: GO:0004753 ! saccharopine dehydrogenase activity

[Term]
id: GO:0004756
name: selenide, water dikinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H(2)O + hydrogen selenide = AMP + 3 H(+) + phosphate + selenophosphorate." [EC:2.7.9.3, RHEA:18740]
subset: gosubset_prok
synonym: "ATP:selenide, water phosphotransferase activity" EXACT [EC:2.7.9.3]
synonym: "selenide,water dikinase activity" EXACT [EC:2.7.9.3]
synonym: "selenium donor protein activity" EXACT [EC:2.7.9.3]
synonym: "selenophosphate synthase activity" EXACT []
synonym: "selenophosphate synthetase activity" EXACT [EC:2.7.9.3]
xref: EC:2.7.9.3
xref: KEGG:R03595
xref: MetaCyc:2.7.9.3-RXN
xref: RHEA:18740
xref: UM-BBD_reactionID:r0833
is_a: GO:0016301 ! kinase activity
is_a: GO:0016781 ! phosphotransferase activity, paired acceptors

[Term]
id: GO:0004757
name: sepiapterin reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH + H+." [EC:1.1.1.153]
subset: gosubset_prok
synonym: "7,8-dihydrobiopterin:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.153]
xref: EC:1.1.1.153
xref: MetaCyc:SEPIAPTERIN-REDUCTASE-RXN
xref: Reactome:REACT_111093 "PTHP is reduced to BH4 by sepiapterin reductase (SPR), Homo sapiens"
xref: Reactome:REACT_111234 "Salvage - Sepiapterin is reduced to BH2, Homo sapiens"
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004758
name: serine C-palmitoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-serine + H(+) + palmitoyl-CoA = 3-dehydrosphinganine + CO(2) + CoA." [EC:2.3.1.50, RHEA:14764]
synonym: "3-oxosphinganine synthetase activity" EXACT [EC:2.3.1.50]
synonym: "acyl-CoA:serine C-2 acyltransferase decarboxylating" RELATED [EC:2.3.1.50]
synonym: "palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity" EXACT [EC:2.3.1.50]
synonym: "serine palmitoyltransferase" BROAD []
synonym: "SPT" RELATED [EC:2.3.1.50]
xref: EC:2.3.1.50
xref: KEGG:R01281
xref: MetaCyc:SERINE-C-PALMITOYLTRANSFERASE-RXN
xref: Reactome:REACT_102132 "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2, Drosophila melanogaster"
xref: Reactome:REACT_102523 "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2, Caenorhabditis elegans"
xref: Reactome:REACT_107523 "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2, Danio rerio"
xref: Reactome:REACT_109567 "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2, Taeniopygia guttata"
xref: Reactome:REACT_113202 "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2, Plasmodium falciparum"
xref: Reactome:REACT_116146 "palmitoyl-CoA + serine => 3-dehydrosphinganine + CoASH + CO2, Gallus gallus"
xref: Reactome:REACT_19401 "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2, Homo sapiens"
xref: Reactome:REACT_32913 "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2, Bos taurus"
xref: Reactome:REACT_78134 "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2, Sus scrofa"
xref: Reactome:REACT_86656 "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2, Oryza sativa"
xref: Reactome:REACT_86827 "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2, Gallus gallus"
xref: Reactome:REACT_89157 "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2, Mus musculus"
xref: Reactome:REACT_90201 "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2, Dictyostelium discoideum"
xref: Reactome:REACT_93748 "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2, Saccharomyces cerevisiae"
xref: Reactome:REACT_96107 "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2, Arabidopsis thaliana"
xref: Reactome:REACT_96113 "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2, Schizosaccharomyces pombe"
xref: Reactome:REACT_96995 "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2, Rattus norvegicus"
xref: Reactome:REACT_97020 "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2, Xenopus tropicalis"
xref: Reactome:REACT_97460 "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2, Canis familiaris"
xref: RHEA:14764
is_a: GO:0016454 ! C-palmitoyltransferase activity

[Term]
id: GO:0004760
name: serine-pyruvate transaminase activity
namespace: molecular_function
alt_id: GO:0004761
alt_id: GO:0004762
alt_id: GO:0004763
def: "Catalysis of the reaction: L-serine + pyruvate = 3-hydroxypyruvate + L-alanine." [EC:2.6.1.51, RHEA:22855]
subset: gosubset_prok
synonym: "hydroxypyruvate:L-alanine transaminase activity" EXACT [EC:2.6.1.51]
synonym: "L-serine:pyruvate aminotransferase activity" EXACT [EC:2.6.1.51]
synonym: "serine--pyruvate aminotransferase activity" EXACT [EC:2.6.1.51]
synonym: "serine-pyruvate aminotransferase activity" EXACT []
synonym: "serine-pyruvate aminotransferase, type 1" NARROW []
synonym: "serine-pyruvate aminotransferase, type 2A" NARROW []
synonym: "serine-pyruvate aminotransferase, type 2B" NARROW []
synonym: "SPT" RELATED [EC:2.6.1.51]
xref: EC:2.6.1.51
xref: KEGG:R00585
xref: MetaCyc:SERINE--PYRUVATE-AMINOTRANSFERASE-RXN
xref: RHEA:22855
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0004764
name: shikimate 3-dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: shikimate + NADP+ = 3-dehydroshikimate + NADPH + H+." [EC:1.1.1.25]
subset: gosubset_prok
synonym: "5-dehydroshikimate reductase activity" EXACT [EC:1.1.1.25]
synonym: "5-dehydroshikimic reductase activity" EXACT [EC:1.1.1.25]
synonym: "dehydroshikimic reductase activity" BROAD [EC:1.1.1.25]
synonym: "DHS reductase activity" BROAD [EC:1.1.1.25]
synonym: "shikimate oxidoreductase activity" BROAD [EC:1.1.1.25]
synonym: "shikimate:NADP(+) 5-oxidoreductase activity" EXACT [EC:1.1.1.25]
synonym: "shikimate:NADP(+) oxidoreductase activity" BROAD [EC:1.1.1.25]
xref: EC:1.1.1.25
xref: EC:1.1.1.282
xref: KEGG:R06847
xref: MetaCyc:SHIKIMATE-5-DEHYDROGENASE-RXN
xref: Reactome:REACT_27289 "Shikimate results from hydration of DHS, Mycobacterium tuberculosis"
xref: RHEA:17740
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004765
name: shikimate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + shikimate = 3-phosphoshikimate + ADP + 2 H(+)." [EC:2.7.1.71, RHEA:13124]
subset: gosubset_prok
synonym: "ATP:shikimate 3-phosphotransferase activity" EXACT [EC:2.7.1.71]
synonym: "shikimate kinase (phosphorylating)" EXACT [EC:2.7.1.71]
synonym: "shikimate kinase II" RELATED [EC:2.7.1.71]
xref: EC:2.7.1.71
xref: KEGG:R02412
xref: MetaCyc:SHIKIMATE-KINASE-RXN
xref: Reactome:REACT_27301 "Phosphorylation of shikimate, Mycobacterium tuberculosis"
xref: RHEA:13124
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0004766
name: spermidine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosylmethioninamine + putrescine = 5'-methylthioadenosine + spermidine." [EC:2.5.1.16]
subset: gosubset_prok
synonym: "aminopropyltransferase activity" EXACT [EC:2.5.1.16]
synonym: "putrescine aminopropyltransferase activity" EXACT [EC:2.5.1.16]
synonym: "S-adenosylmethioninamine:putrescine 3-aminopropyltransferase activity" EXACT [EC:2.5.1.16]
synonym: "SpeE" RELATED [EC:2.5.1.16]
synonym: "spermidine synthetase activity" EXACT [EC:2.5.1.16]
xref: EC:2.5.1.16
xref: MetaCyc:SPERMIDINESYN-RXN
xref: Reactome:REACT_101050 "Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine, Saccharomyces cerevisiae"
xref: Reactome:REACT_101472 "Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine, Drosophila melanogaster"
xref: Reactome:REACT_104649 "Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine, Rattus norvegicus"
xref: Reactome:REACT_104998 "Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine, Sus scrofa"
xref: Reactome:REACT_106340 "Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine, Schizosaccharomyces pombe"
xref: Reactome:REACT_108423 "Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine, Mus musculus"
xref: Reactome:REACT_109429 "Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine, Gallus gallus"
xref: Reactome:REACT_110546 "Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine, Plasmodium falciparum"
xref: Reactome:REACT_14788 "Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine, Homo sapiens"
xref: Reactome:REACT_29221 "Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine, Xenopus tropicalis"
xref: Reactome:REACT_30507 "Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine, Bos taurus"
xref: Reactome:REACT_31767 "Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine, Dictyostelium discoideum"
xref: Reactome:REACT_31945 "Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine, Arabidopsis thaliana"
xref: Reactome:REACT_33237 "Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine, Canis familiaris"
xref: Reactome:REACT_79416 "Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine, Caenorhabditis elegans"
xref: Reactome:REACT_88709 "Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine, Danio rerio"
xref: Reactome:REACT_92788 "Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine, Taeniopygia guttata"
xref: Reactome:REACT_96311 "Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine, Escherichia coli"
xref: Reactome:REACT_98525 "Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine, Oryza sativa"
xref: RHEA:12724
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0004767
name: sphingomyelin phosphodiesterase activity
namespace: molecular_function
alt_id: GO:0030230
alt_id: GO:0030231
def: "Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+)." [EC:3.1.4.12, RHEA:19256]
subset: goslim_chembl
subset: gosubset_prok
synonym: "sphingomyelin cholinephosphohydrolase activity" EXACT [EC:3.1.4.12]
synonym: "sphingomyelinase activity" EXACT []
xref: EC:3.1.4.12
xref: KEGG:R02541
xref: MetaCyc:SPHINGOMYELIN-PHOSPHODIESTERASE-RXN
xref: Reactome:REACT_106320 "Production of ceramide which can activate JNK and other targets, Taeniopygia guttata"
xref: Reactome:REACT_106769 "Production of ceramide which can activate JNK and other targets, Saccharomyces cerevisiae"
xref: Reactome:REACT_110644 "Production of ceramide which can activate JNK and other targets, Xenopus tropicalis"
xref: Reactome:REACT_115560 "Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin, Homo sapiens"
xref: Reactome:REACT_115857 "Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane), Homo sapiens"
xref: Reactome:REACT_116064 "Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane), Homo sapiens"
xref: Reactome:REACT_116148 "Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome), Homo sapiens"
xref: Reactome:REACT_13750 "Production of ceramide which can activate JNK and other targets, Rattus norvegicus"
xref: Reactome:REACT_13752 "Production of ceramide which can activate JNK and other targets, Homo sapiens"
xref: Reactome:REACT_29592 "Production of ceramide which can activate JNK and other targets, Danio rerio"
xref: Reactome:REACT_30235 "Production of ceramide which can activate JNK and other targets, Drosophila melanogaster"
xref: Reactome:REACT_31542 "Production of ceramide which can activate JNK and other targets, Caenorhabditis elegans"
xref: Reactome:REACT_33689 "Production of ceramide which can activate JNK and other targets, Bos taurus"
xref: Reactome:REACT_34798 "Production of ceramide which can activate JNK and other targets, Canis familiaris"
xref: Reactome:REACT_84506 "Production of ceramide which can activate JNK and other targets, Mus musculus"
xref: Reactome:REACT_88771 "Production of ceramide which can activate JNK and other targets, Sus scrofa"
xref: Reactome:REACT_91464 "Production of ceramide which can activate JNK and other targets, Gallus gallus"
xref: Reactome:REACT_91647 "Production of ceramide which can activate JNK and other targets, Schizosaccharomyces pombe"
xref: RHEA:19256
is_a: GO:0004620 ! phospholipase activity
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0004768
name: stearoyl-CoA 9-desaturase activity
namespace: molecular_function
alt_id: GO:0016214
alt_id: GO:0043735
def: "Catalysis of the reaction: stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + H2O." [EC:1.14.19.1]
comment: Note that this function was formerly EC:1.14.99.5.
subset: gosubset_prok
synonym: "acyl-CoA desaturase activity" BROAD [EC:1.14.19.1]
synonym: "delta(9)-desaturase activity" BROAD [EC:1.14.19.1]
synonym: "delta-9 acyl-phospholipid desaturase activity" RELATED []
synonym: "delta9-desaturase activity" BROAD [EC:1.14.19.1]
synonym: "fatty acid desaturase activity" BROAD [EC:1.14.19.1]
synonym: "stearoyl-CoA desaturase activity" BROAD []
synonym: "stearoyl-CoA, hydrogen-donor:oxygen oxidoreductase activity" EXACT [EC:1.14.19.1]
synonym: "stearoyl-CoA,ferrocytochrome-b5:oxygen oxidoreductase (9,10-dehydrogenating)" EXACT [EC:1.14.19.1]
xref: EC:1.14.19.1
xref: MetaCyc:1.14.19.1-RXN
is_a: GO:0016215 ! acyl-CoA desaturase activity

[Term]
id: GO:0004769
name: steroid delta-isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 3-oxo-delta(5)-steroid = a 3-oxo-delta(4)-steroid." [EC:5.3.3.1]
subset: gosubset_prok
synonym: "3-oxosteroid delta5-delta4-isomerase activity" EXACT [EC:5.3.3.1]
synonym: "3-oxosteroid isomerase activity" EXACT [EC:5.3.3.1]
synonym: "delta(5)-3-keto steroid isomerase activity" EXACT [EC:5.3.3.1]
synonym: "delta(5)-3-ketosteroid isomerase activity" EXACT [EC:5.3.3.1]
synonym: "delta(5)-3-oxosteroid isomerase activity" EXACT [EC:5.3.3.1]
synonym: "delta(5)-steroid isomerase activity" EXACT [EC:5.3.3.1]
synonym: "delta5(or delta4)-3-keto steroid isomerase activity" EXACT [EC:5.3.3.1]
synonym: "delta5-3-keto steroid isomerase activity" EXACT [EC:5.3.3.1]
synonym: "delta5-3-ketosteroid isomerase activity" EXACT [EC:5.3.3.1]
synonym: "delta5-3-oxosteroid isomerase activity" EXACT [EC:5.3.3.1]
synonym: "delta5-ketosteroid isomerase activity" EXACT [EC:5.3.3.1]
synonym: "delta5-steroid isomerase activity" EXACT [EC:5.3.3.1]
synonym: "hydroxysteroid isomerase activity" EXACT [EC:5.3.3.1]
synonym: "steroid D-isomerase activity" EXACT []
synonym: "steroid isomerase activity" EXACT [EC:5.3.3.1]
xref: EC:5.3.3.1
xref: MetaCyc:STEROID-DELTA-ISOMERASE-RXN
xref: Reactome:REACT_10021 "Pregn-5-ene-3,20-dione isomerizes to progesterone, Homo sapiens"
xref: Reactome:REACT_10056 "DHA isomerizes to 4-Androstene3,17-dione, Homo sapiens"
xref: Reactome:REACT_101989 "DHA isomerizes to 4-Androstene3,17-dione, Danio rerio"
xref: Reactome:REACT_107797 "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone, Sus scrofa"
xref: Reactome:REACT_107969 "Pregn-5-ene-3,20-dione isomerizes to progesterone, Drosophila melanogaster"
xref: Reactome:REACT_108682 "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol, Mus musculus"
xref: Reactome:REACT_108696 "Pregn-5-ene-3,20-dione isomerizes to progesterone, Taeniopygia guttata"
xref: Reactome:REACT_108790 "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone, Danio rerio"
xref: Reactome:REACT_108895 "DHA isomerizes to 4-Androstene3,17-dione, Rattus norvegicus"
xref: Reactome:REACT_108927 "DHA isomerizes to 4-Androstene3,17-dione, Mus musculus"
xref: Reactome:REACT_109349 "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone, Taeniopygia guttata"
xref: Reactome:REACT_110201 "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol, Danio rerio"
xref: Reactome:REACT_110280 "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone, Gallus gallus"
xref: Reactome:REACT_112222 "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone, Mycobacterium tuberculosis"
xref: Reactome:REACT_112738 "Pregn-5-ene-3,20-dione isomerizes to progesterone, Escherichia coli"
xref: Reactome:REACT_113344 "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone, Escherichia coli"
xref: Reactome:REACT_113857 "Pregn-5-ene-3,20-dione isomerizes to progesterone, Mycobacterium tuberculosis"
xref: Reactome:REACT_113969 "DHA isomerizes to 4-Androstene3,17-dione, Mycobacterium tuberculosis"
xref: Reactome:REACT_114179 "DHA isomerizes to 4-Androstene3,17-dione, Escherichia coli"
xref: Reactome:REACT_114390 "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol, Arabidopsis thaliana"
xref: Reactome:REACT_114902 "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol, Oryza sativa"
xref: Reactome:REACT_29459 "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol, Dictyostelium discoideum"
xref: Reactome:REACT_30014 "DHA isomerizes to 4-Androstene3,17-dione, Bos taurus"
xref: Reactome:REACT_30329 "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone, Mus musculus"
xref: Reactome:REACT_31470 "Pregn-5-ene-3,20-dione isomerizes to progesterone, Gallus gallus"
xref: Reactome:REACT_31658 "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone, Xenopus tropicalis"
xref: Reactome:REACT_33051 "DHA isomerizes to 4-Androstene3,17-dione, Canis familiaris"
xref: Reactome:REACT_33925 "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol, Rattus norvegicus"
xref: Reactome:REACT_82604 "Pregn-5-ene-3,20-dione isomerizes to progesterone, Bos taurus"
xref: Reactome:REACT_83473 "DHA isomerizes to 4-Androstene3,17-dione, Taeniopygia guttata"
xref: Reactome:REACT_85024 "Pregn-5-ene-3,20-dione isomerizes to progesterone, Xenopus tropicalis"
xref: Reactome:REACT_89982 "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone, Canis familiaris"
xref: Reactome:REACT_90008 "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone, Rattus norvegicus"
xref: Reactome:REACT_91368 "Pregn-5-ene-3,20-dione isomerizes to progesterone, Rattus norvegicus"
xref: Reactome:REACT_91499 "DHA isomerizes to 4-Androstene3,17-dione, Xenopus tropicalis"
xref: Reactome:REACT_92131 "Pregn-5-ene-3,20-dione isomerizes to progesterone, Danio rerio"
xref: Reactome:REACT_92786 "DHA isomerizes to 4-Androstene3,17-dione, Drosophila melanogaster"
xref: Reactome:REACT_93338 "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol, Bos taurus"
xref: Reactome:REACT_93803 "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol, Canis familiaris"
xref: Reactome:REACT_94565 "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone, Drosophila melanogaster"
xref: Reactome:REACT_95541 "Pregn-5-ene-3,20-dione isomerizes to progesterone, Canis familiaris"
xref: Reactome:REACT_95601 "Pregn-5-ene-3,20-dione isomerizes to progesterone, Mus musculus"
xref: Reactome:REACT_95626 "DHA isomerizes to 4-Androstene3,17-dione, Gallus gallus"
xref: Reactome:REACT_96167 "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone, Bos taurus"
xref: Reactome:REACT_96816 "Pregn-5-ene-3,20-dione isomerizes to progesterone, Sus scrofa"
xref: Reactome:REACT_98326 "DHA isomerizes to 4-Androstene3,17-dione, Sus scrofa"
xref: Reactome:REACT_9981 "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone, Homo sapiens"
xref: Reactome:REACT_9999 "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol, Homo sapiens"
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0004771
name: sterol esterase activity
namespace: molecular_function
def: "Catalysis of the reaction: a steryl ester + H2O = a sterol + a fatty acid." [EC:3.1.1.13]
subset: goslim_chembl
synonym: "acylcholesterol lipase activity" EXACT [EC:3.1.1.13]
synonym: "cholesterase activity" EXACT [EC:3.1.1.13]
synonym: "cholesterol ester hydrolase activity" EXACT [EC:3.1.1.13]
synonym: "cholesterol ester synthase activity" NARROW [EC:3.1.1.13]
synonym: "cholesterol esterase activity" NARROW [EC:3.1.1.13]
synonym: "cholesteryl ester hydrolase activity" EXACT [EC:3.1.1.13]
synonym: "cholesteryl ester synthase activity" EXACT [EC:3.1.1.13]
synonym: "cholesteryl esterase activity" EXACT [EC:3.1.1.13]
synonym: "sterol ester hydrolase activity" EXACT [EC:3.1.1.13]
synonym: "steryl-ester acylhydrolase activity" EXACT [EC:3.1.1.13]
synonym: "triterpenol esterase activity" EXACT [EC:3.1.1.13]
xref: EC:3.1.1.13
xref: MetaCyc:STEROL-ESTERASE-RXN
xref: Reactome:REACT_108039 "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase), Bos taurus"
xref: Reactome:REACT_110768 "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase), Gallus gallus"
xref: Reactome:REACT_28907 "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase), Taeniopygia guttata"
xref: Reactome:REACT_32955 "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase), Canis familiaris"
xref: Reactome:REACT_59464 "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase), Mus musculus"
xref: Reactome:REACT_82975 "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase), Rattus norvegicus"
xref: Reactome:REACT_87504 "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase), Danio rerio"
xref: Reactome:REACT_9468 "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase), Homo sapiens"
xref: Reactome:REACT_97257 "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase), Xenopus tropicalis"
is_a: GO:0016298 ! lipase activity
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0004772
name: sterol O-acyltransferase activity
namespace: molecular_function
alt_id: GO:0017066
def: "Catalysis of the reaction: acyl-CoA + a sterol = CoA + a sterol ester." [EC:2.3.1.26, GOC:mah]
synonym: "sterol-ester synthase activity" EXACT [EC:2.3.1.26]
synonym: "sterol-ester synthetase activity" EXACT [EC:2.3.1.26]
xref: EC:2.3.1.-
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0004773
name: steryl-sulfatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O = 3-beta-hydroxyandrost-5-en-17-one + sulfate." [EC:3.1.6.2]
synonym: "3-beta-hydroxysteroid sulfate sulfatase activity" EXACT [EC:3.1.6.2]
synonym: "arylsulfatase C activity" EXACT [EC:3.1.6.2]
synonym: "dehydroepiandrosterone sulfatase activity" EXACT [EC:3.1.6.2]
synonym: "dehydroepiandrosterone sulfate sulfatase activity" EXACT [EC:3.1.6.2]
synonym: "phenolic steroid sulfatase activity" EXACT [EC:3.1.6.2]
synonym: "pregnenolone sulfatase activity" EXACT [EC:3.1.6.2]
synonym: "steroid 3-sulfatase activity" EXACT [EC:3.1.6.2]
synonym: "steroid sulfatase activity" EXACT [EC:3.1.6.2]
synonym: "steroid sulfate sulfohydrolase activity" EXACT [EC:3.1.6.2]
synonym: "sterol sulfatase activity" EXACT [EC:3.1.6.2]
synonym: "steryl-sulfate sulfohydrolase activity" EXACT [EC:3.1.6.2]
synonym: "steryl-sulphatase activity" EXACT []
xref: EC:3.1.6.2
xref: MetaCyc:STERYL-SULFATASE-RXN
xref: Reactome:REACT_115686 "Steryl sulfatase hydrolyses sulfate from steroid sulfates, Homo sapiens"
xref: RHEA:19876
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0004774
name: succinate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: succinate + CoA + nucleotide triphosphate = nucleotide diphosphate + phosphate + succinyl-CoA." [EC:6.2.1.-, GOC:ai]
subset: gosubset_prok
xref: EC:6.2.1.-
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0004775
name: succinate-CoA ligase (ADP-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + succinate + CoA = ADP + succinyl-CoA + phosphate." [EC:6.2.1.5]
subset: gosubset_prok
synonym: "A-SCS" RELATED [EC:6.2.1.5]
synonym: "A-STK (adenin nucleotide-linked succinate thiokinase)" RELATED [EC:6.2.1.5]
synonym: "succinate thiokinase activity" EXACT [EC:6.2.1.5]
synonym: "succinate:CoA ligase (ADP-forming) activity" EXACT [EC:6.2.1.5]
synonym: "succinic thiokinase" BROAD [EC:6.2.1.5]
synonym: "succinyl coenzyme A synthetase" BROAD [EC:6.2.1.5]
synonym: "succinyl coenzyme A synthetase (adenosine diphosphate-forming) activity" EXACT [EC:6.2.1.5]
synonym: "succinyl-CoA synthetase (ADP-forming) activity" EXACT [EC:6.2.1.5]
synonym: "succinyl-CoA synthetase activity" EXACT [EC:6.2.1.5]
xref: EC:6.2.1.5
xref: KEGG:R00405
xref: MetaCyc:SUCCCOASYN-RXN
xref: Reactome:REACT_101732 "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA, Canis familiaris"
xref: Reactome:REACT_104742 "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA, Drosophila melanogaster"
xref: Reactome:REACT_115573 "succinylCoA + ADP + Pi <=> succinate + CoASH + ATP, Gallus gallus"
xref: Reactome:REACT_115972 "succinate + CoASH + ATP <=> succinylCoA + ADP + Pi, Gallus gallus"
xref: Reactome:REACT_34281 "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA, Xenopus tropicalis"
xref: Reactome:REACT_629 "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA, Homo sapiens"
xref: Reactome:REACT_77306 "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA, Bos taurus"
xref: Reactome:REACT_84969 "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA, Taeniopygia guttata"
xref: Reactome:REACT_85345 "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA, Gallus gallus"
xref: Reactome:REACT_88405 "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA, Danio rerio"
xref: Reactome:REACT_90544 "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA, Sus scrofa"
xref: Reactome:REACT_94494 "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA, Mus musculus"
xref: Reactome:REACT_94882 "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA, Caenorhabditis elegans"
xref: Reactome:REACT_96099 "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA, Rattus norvegicus"
xref: RHEA:17664
is_a: GO:0004774 ! succinate-CoA ligase activity

[Term]
id: GO:0004776
name: succinate-CoA ligase (GDP-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP + succinate + CoA = GDP + succinyl-CoA + phosphate." [EC:6.2.1.4]
subset: gosubset_prok
synonym: "G-STK" RELATED [EC:6.2.1.4]
synonym: "P-enzyme" RELATED [EC:6.2.1.4]
synonym: "SCS" RELATED [EC:6.2.1.4]
synonym: "succinate-phosphorylating enzyme" RELATED [EC:6.2.1.4]
synonym: "succinate:CoA ligase (GDP-forming) activity" EXACT [EC:6.2.1.4]
synonym: "succinic thiokinase" BROAD [EC:6.2.1.4]
synonym: "succinyl CoA synthetase activity" EXACT [EC:6.2.1.4]
synonym: "succinyl coenzyme A synthetase" BROAD [EC:6.2.1.4]
synonym: "succinyl coenzyme A synthetase (GDP-forming) activity" EXACT [EC:6.2.1.4]
synonym: "succinyl coenzyme A synthetase (guanosine diphosphate-forming) activity" EXACT [EC:6.2.1.4]
synonym: "succinyl-CoA synthetase (GDP-forming) activity" EXACT [EC:6.2.1.4]
xref: EC:6.2.1.4
xref: KEGG:R00432
xref: MetaCyc:SUCCINATE--COA-LIGASE-GDP-FORMING-RXN
xref: Reactome:REACT_106266 "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA, Sus scrofa"
xref: Reactome:REACT_106355 "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA, Bos taurus"
xref: Reactome:REACT_107711 "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA, Danio rerio"
xref: Reactome:REACT_115751 "succinylCoA + GDP + Pi <=> succinate + CoASH + GTP, Gallus gallus"
xref: Reactome:REACT_115829 "succinate + CoASH + GTP <=> succinylCoA + GDP + Pi, Gallus gallus"
xref: Reactome:REACT_30069 "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA, Caenorhabditis elegans"
xref: Reactome:REACT_31210 "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA, Rattus norvegicus"
xref: Reactome:REACT_32980 "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA, Gallus gallus"
xref: Reactome:REACT_337 "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA, Homo sapiens"
xref: Reactome:REACT_34598 "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA, Drosophila melanogaster"
xref: Reactome:REACT_86430 "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA, Xenopus tropicalis"
xref: Reactome:REACT_95682 "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA, Mus musculus"
xref: Reactome:REACT_96173 "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA, Taeniopygia guttata"
xref: Reactome:REACT_98092 "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA, Canis familiaris"
xref: RHEA:22123
is_a: GO:0004774 ! succinate-CoA ligase activity

[Term]
id: GO:0004777
name: succinate-semialdehyde dehydrogenase (NAD+) activity
namespace: molecular_function
alt_id: GO:0008952
def: "Catalysis of the reaction: succinate semialdehyde + NAD+ + H2O = succinate + NADH + H+." [EC:1.2.1.24]
subset: gosubset_prok
synonym: "succinate semialdehyde dehydrogenase activity" BROAD [EC:1.2.1.24]
synonym: "succinate semialdehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.24]
synonym: "succinate-semialdehyde dehydrogenase activity" BROAD [GOC:bf]
synonym: "succinate-semialdehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.24]
synonym: "succinic semialdehyde dehydrogenase activity" BROAD [EC:1.2.1.24]
synonym: "succinyl semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.24]
xref: EC:1.2.1.24
xref: MetaCyc:SUCCINATE-SEMIALDEHYDE-DEHYDROGENASE-RXN
xref: Reactome:REACT_24017 "Conversion of succinate semialdehyde to succinate, Homo sapiens"
xref: RHEA:13220
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004778
name: succinyl-CoA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + succinyl-CoA = CoA + H(+) + succinate." [EC:3.1.2.3, RHEA:11519]
synonym: "succinyl coenzyme A deacylase activity" EXACT [EC:3.1.2.3]
synonym: "succinyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.3]
synonym: "succinyl-CoA acylase activity" EXACT [EC:3.1.2.3]
xref: EC:3.1.2.3
xref: KEGG:R00407
xref: MetaCyc:SUCCINYL-COA-HYDROLASE-RXN
xref: RHEA:11519
is_a: GO:0016289 ! CoA hydrolase activity

[Term]
id: GO:0004779
name: sulfate adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an adenylyl group from an adenosine nucleotide (ATP or ADP) to sulfate, forming adenylylsulfate." [GOC:mah, MetaCyc:SULFATE-ADENYLYLTRANS-RXN, MetaCyc:SULFATE-ADENYLYLTRANSFERASE-ADP-RXN]
subset: gosubset_prok
synonym: "sulphate adenylyltransferase activity" EXACT []
xref: EC:2.7.7.-
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0004780
name: sulfate adenylyltransferase (ADP) activity
namespace: molecular_function
def: "Catalysis of the reaction: ADP + H(+) + sulfate = 5'-adenylyl sulfate + phosphate." [EC:2.7.7.5, RHEA:16532]
synonym: "adenosine diphosphate sulfurylase activity" EXACT [EC:2.7.7.5]
synonym: "ADP-sulfurylase activity" EXACT [EC:2.7.7.5]
synonym: "ADP:sulfate adenylyltransferase activity" EXACT []
synonym: "sulfate (adenosine diphosphate) adenylyltransferase activity" EXACT [EC:2.7.7.5]
synonym: "sulphate adenylyltransferase (ADP) activity" EXACT []
xref: EC:2.7.7.5
xref: KEGG:R00530
xref: MetaCyc:SULFATE-ADENYLYLTRANSFERASE-ADP-RXN
xref: RHEA:16532
is_a: GO:0004779 ! sulfate adenylyltransferase activity

[Term]
id: GO:0004781
name: sulfate adenylyltransferase (ATP) activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + sulfate = diphosphate + adenylylsulfate." [EC:2.7.7.4]
subset: gosubset_prok
synonym: "adenosine-5'-triphosphate sulfurylase activity" EXACT [EC:2.7.7.4]
synonym: "adenosinetriphosphate sulfurylase activity" EXACT [EC:2.7.7.4]
synonym: "adenylylsulfate pyrophosphorylase activity" EXACT [EC:2.7.7.4]
synonym: "ATP sulfurylase activity" EXACT [EC:2.7.7.4]
synonym: "ATP-sulfurylase activity" EXACT [EC:2.7.7.4]
synonym: "ATP:sulfate adenylyltransferase activity" EXACT []
synonym: "sulfate adenylate transferase activity" EXACT [EC:2.7.7.4]
synonym: "sulfurylase activity" RELATED [EC:2.7.7.4]
synonym: "sulphate adenylyltransferase (ATP) activity" EXACT []
xref: EC:2.7.7.4
xref: MetaCyc:SULFATE-ADENYLYLTRANS-RXN
xref: Reactome:REACT_100457 "ATP + sulfate => adenylyl sulfate (APS) + pyrophosphate, Mus musculus"
xref: Reactome:REACT_102507 "ATP + sulfate => adenylyl sulfate (APS) + pyrophosphate, Danio rerio"
xref: Reactome:REACT_112565 "ATP + sulfate => adenylyl sulfate (APS) + pyrophosphate, Escherichia coli"
xref: Reactome:REACT_27213 "sulfate is activated to APS, Mycobacterium tuberculosis"
xref: Reactome:REACT_61348 "ATP + sulfate => adenylyl sulfate (APS) + pyrophosphate, Gallus gallus"
xref: Reactome:REACT_6767 "ATP + sulfate => adenylyl sulfate (APS) + pyrophosphate, Homo sapiens"
xref: Reactome:REACT_77226 "ATP + sulfate => adenylyl sulfate (APS) + pyrophosphate, Caenorhabditis elegans"
xref: Reactome:REACT_77444 "ATP + sulfate => adenylyl sulfate (APS) + pyrophosphate, Sus scrofa"
xref: Reactome:REACT_80385 "ATP + sulfate => adenylyl sulfate (APS) + pyrophosphate, Bos taurus"
xref: Reactome:REACT_80389 "ATP + sulfate => adenylyl sulfate (APS) + pyrophosphate, Arabidopsis thaliana"
xref: Reactome:REACT_86638 "ATP + sulfate => adenylyl sulfate (APS) + pyrophosphate, Drosophila melanogaster"
xref: Reactome:REACT_87546 "ATP + sulfate => adenylyl sulfate (APS) + pyrophosphate, Canis familiaris"
xref: Reactome:REACT_89970 "ATP + sulfate => adenylyl sulfate (APS) + pyrophosphate, Xenopus tropicalis"
xref: Reactome:REACT_90306 "ATP + sulfate => adenylyl sulfate (APS) + pyrophosphate, Oryza sativa"
xref: Reactome:REACT_93350 "ATP + sulfate => adenylyl sulfate (APS) + pyrophosphate, Rattus norvegicus"
xref: Reactome:REACT_93651 "ATP + sulfate => adenylyl sulfate (APS) + pyrophosphate, Taeniopygia guttata"
xref: RHEA:18136
is_a: GO:0004779 ! sulfate adenylyltransferase activity

[Term]
id: GO:0004782
name: sulfinoalanine decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-sulfino-L-alanine = hypotaurine + CO2." [EC:4.1.1.29]
synonym: "3-sulfino-L-alanine carboxy-lyase (hypotaurine-forming)" EXACT [EC:4.1.1.29]
synonym: "3-sulfino-L-alanine carboxy-lyase activity" EXACT [EC:4.1.1.29]
synonym: "CADCase/CSADCase activity" EXACT [EC:4.1.1.29]
synonym: "CSAD" RELATED [EC:4.1.1.29]
synonym: "CSADCase activity" EXACT [EC:4.1.1.29]
synonym: "cysteic decarboxylase activity" EXACT [EC:4.1.1.29]
synonym: "cysteine-sulfinate decarboxylase activity" EXACT [EC:4.1.1.29]
synonym: "cysteinesulfinate decarboxylase activity" EXACT [EC:4.1.1.29]
synonym: "cysteinesulfinic acid decarboxylase activity" EXACT [EC:4.1.1.29]
synonym: "L-cysteinesulfinic acid decarboxylase activity" EXACT [EC:4.1.1.29]
synonym: "sulfoalanine decarboxylase activity" EXACT [EC:4.1.1.29]
synonym: "sulphinoalanine decarboxylase activity" EXACT []
xref: EC:4.1.1.29
xref: MetaCyc:SULFINOALANINE-DECARBOXYLASE-RXN
xref: Reactome:REACT_115820 "CSAD decarboxylates 3-sulfinoalanine to hypotaurine, Homo sapiens"
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004783
name: sulfite reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrogen sulfide + 3 NADP+ + 3 H2O = sulfite + 3 NADPH + 3 H+." [EC:1.8.1.2]
subset: gosubset_prok
synonym: "H2S-NADP oxidoreductase activity" EXACT [EC:1.8.1.2]
synonym: "hydrogen-sulfide:NADP+ oxidoreductase activity" EXACT [EC:1.8.1.2]
synonym: "NADPH-dependent sulfite reductase activity" EXACT [EC:1.8.1.2]
synonym: "NADPH-sulfite reductase activity" EXACT [EC:1.8.1.2]
synonym: "NADPH:sulfite reductase flavoprotein" RELATED []
synonym: "sulfite (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.8.1.2]
synonym: "sulphite reductase (NADPH) activity" EXACT []
xref: EC:1.8.1.2
xref: MetaCyc:SULFITE-REDUCT-RXN
xref: RHEA:13804
is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor

[Term]
id: GO:0004784
name: superoxide dismutase activity
namespace: molecular_function
alt_id: GO:0004785
alt_id: GO:0008382
alt_id: GO:0008383
alt_id: GO:0016954
def: "Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide." [EC:1.15.1.1, GOC:vw, PMID:15064408]
subset: gosubset_prok
synonym: "copper, zinc superoxide dismutase activity" NARROW []
synonym: "Cu,Zn-SOD" RELATED [EC:1.15.1.1]
synonym: "Cu-Zn superoxide dismutase activity" NARROW [EC:1.15.1.1]
synonym: "cuprein" RELATED [EC:1.15.1.1]
synonym: "cytocuprein" RELATED [EC:1.15.1.1]
synonym: "erythrocuprein" RELATED [EC:1.15.1.1]
synonym: "Fe-SOD" RELATED [EC:1.15.1.1]
synonym: "ferrisuperoxide dismutase activity" NARROW [EC:1.15.1.1]
synonym: "hemocuprein" RELATED [EC:1.15.1.1]
synonym: "hepatocuprein" RELATED [EC:1.15.1.1]
synonym: "iron superoxide dismutase activity" NARROW []
synonym: "iron superoxide oxidoreductase" RELATED []
synonym: "manganese superoxide dismutase activity" NARROW []
synonym: "manganese superoxide oxidoreductase" RELATED []
synonym: "Mn, Fe superoxide dismutase" NARROW []
synonym: "Mn-SOD" RELATED [EC:1.15.1.1]
synonym: "nickel superoxide dismutase activity" NARROW []
synonym: "nickel superoxide oxidoreductase" RELATED []
synonym: "SOD" RELATED [EC:1.15.1.1]
synonym: "SOD-1" RELATED [EC:1.15.1.1]
synonym: "SOD-2" RELATED [EC:1.15.1.1]
synonym: "SOD-3" RELATED [EC:1.15.1.1]
synonym: "SOD-4" RELATED [EC:1.15.1.1]
synonym: "SODF" RELATED [EC:1.15.1.1]
synonym: "SODS" RELATED [EC:1.15.1.1]
synonym: "superoxide dismutase I" RELATED [EC:1.15.1.1]
synonym: "superoxide dismutase II" RELATED [EC:1.15.1.1]
synonym: "superoxide:superoxide oxidoreductase activity" EXACT []
synonym: "zinc superoxide oxidoreductase" RELATED []
xref: EC:1.15.1.1
xref: MetaCyc:SUPEROX-DISMUT-RXN
xref: RHEA:20699
is_a: GO:0016209 ! antioxidant activity
is_a: GO:0016721 ! oxidoreductase activity, acting on superoxide radicals as acceptor
relationship: part_of GO:0019430 ! removal of superoxide radicals

[Term]
id: GO:0004786
name: obsolete Mn, Fe superoxide dismutase
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because the function is covered by an existing term.
synonym: "Mn, Fe superoxide dismutase" EXACT []
is_obsolete: true
consider: GO:0004784

[Term]
id: GO:0004787
name: thiamine-pyrophosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: TDP + H2O = TMP + phosphate." [EC:3.6.1.-, GOC:ai]
synonym: "thiamin pyrophosphatase activity" EXACT []
synonym: "thiamin-pyrophosphatase activity" EXACT [GOC:curators]
synonym: "thiamine pyrophosphatase activity" EXACT []
synonym: "thiaminpyrophosphatase activity" EXACT [EC:3.6.1.6]
synonym: "TPPase activity" EXACT []
xref: EC:3.6.1.-
is_a: GO:0017110 ! nucleoside-diphosphatase activity

[Term]
id: GO:0004788
name: thiamine diphosphokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + thiamine = AMP + thiamine diphosphate." [EC:2.7.6.2]
subset: gosubset_prok
synonym: "ATP:thiamin pyrophosphotransferase activity" EXACT [EC:2.7.6.2]
synonym: "ATP:thiamine diphosphotransferase activity" EXACT [EC:2.7.6.2]
synonym: "thiamin diphosphokinase activity" EXACT [GOC:curators]
synonym: "thiamin pyrophosphokinase activity" EXACT []
synonym: "thiamin pyrophosphotransferase activity" EXACT [EC:2.7.6.2]
synonym: "thiamin:ATP pyrophosphotransferase activity" EXACT [EC:2.7.6.2]
synonym: "thiamine pyrophosphokinase activity" EXACT []
synonym: "thiaminokinase activity" EXACT [EC:2.7.6.2]
synonym: "TPTase activity" EXACT [EC:2.7.6.2]
xref: EC:2.7.6.2
xref: MetaCyc:THIAMIN-PYROPHOSPHOKINASE-RXN
xref: Reactome:REACT_102242 "Thiamin is pyrophosphorylated, Mus musculus"
xref: Reactome:REACT_104766 "Thiamin is pyrophosphorylated, Canis familiaris"
xref: Reactome:REACT_108061 "Thiamin is pyrophosphorylated, Saccharomyces cerevisiae"
xref: Reactome:REACT_11233 "Thiamin is pyrophosphorylated, Homo sapiens"
xref: Reactome:REACT_29181 "Thiamin is pyrophosphorylated, Oryza sativa"
xref: Reactome:REACT_29244 "Thiamin is pyrophosphorylated, Bos taurus"
xref: Reactome:REACT_30803 "Thiamin is pyrophosphorylated, Rattus norvegicus"
xref: Reactome:REACT_32304 "Thiamin is pyrophosphorylated, Sus scrofa"
xref: Reactome:REACT_32784 "Thiamin is pyrophosphorylated, Caenorhabditis elegans"
xref: Reactome:REACT_78592 "Thiamin is pyrophosphorylated, Taeniopygia guttata"
xref: Reactome:REACT_84784 "Thiamin is pyrophosphorylated, Xenopus tropicalis"
xref: Reactome:REACT_87137 "Thiamin is pyrophosphorylated, Drosophila melanogaster"
xref: Reactome:REACT_87156 "Thiamin is pyrophosphorylated, Danio rerio"
xref: Reactome:REACT_89139 "Thiamin is pyrophosphorylated, Plasmodium falciparum"
xref: Reactome:REACT_89462 "Thiamin is pyrophosphorylated, Arabidopsis thaliana"
xref: Reactome:REACT_96391 "Thiamin is pyrophosphorylated, Dictyostelium discoideum"
xref: Reactome:REACT_99319 "Thiamin is pyrophosphorylated, Gallus gallus"
xref: RHEA:11579
is_a: GO:0016778 ! diphosphotransferase activity

[Term]
id: GO:0004789
name: thiamine-phosphate diphosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-amino-2-methyl-5-diphosphomethylpyrimidine + 4-methyl-5-(2-phosphoethyl)-thiazole + H(+) = diphosphate + thiamine phosphate." [EC:2.5.1.3, RHEA:22331]
subset: gosubset_prok
synonym: "2-methyl-4-amino-5-hydroxymethylpyrimidine-diphosphate:4-methyl-5-(2-phosphoethyl)thiazole 2-methyl-4-aminopyrimidine-5-methenyltransferase activity" EXACT [EC:2.5.1.3]
synonym: "thiamin-phosphate diphosphorylase activity" EXACT [GOC:curators]
synonym: "thiamin-phosphate pyrophosphorylase activity" EXACT []
synonym: "thiamine monophosphate pyrophosphorylase activity" EXACT [EC:2.5.1.3]
synonym: "thiamine phosphate pyrophosphorylase activity" EXACT [EC:2.5.1.3]
synonym: "thiamine-phosphate pyrophosphorylase activity" EXACT []
synonym: "thiamine-phosphate synthase activity" EXACT [EC:2.5.1.3]
synonym: "TMP diphosphorylase activity" EXACT [EC:2.5.1.3]
synonym: "TMP pyrophosphorylase activity" EXACT [EC:2.5.1.3]
synonym: "TMP-PPase activity" EXACT [EC:2.5.1.3]
xref: EC:2.5.1.3
xref: KEGG:R03223
xref: MetaCyc:THI-P-SYN-RXN
xref: RHEA:22331
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0004790
name: thioether S-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + dimethyl sulfide = S-adenosyl-L-homocysteine + trimethylsulfonium." [EC:2.1.1.96, RHEA:19616]
synonym: "S-adenosyl-L-methionine:dimethyl-sulfide S-methyltransferase activity" EXACT [EC:2.1.1.96]
synonym: "S-adenosyl-L-methionine:thioether S-methyltransferase activity" EXACT [EC:2.1.1.96]
synonym: "thioether methyltransferase activity" EXACT [EC:2.1.1.96]
xref: EC:2.1.1.96
xref: KEGG:R02572
xref: MetaCyc:THIOETHER-S-METHYLTRANSFERASE-RXN
xref: RHEA:19616
is_a: GO:0008172 ! S-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0004791
name: thioredoxin-disulfide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP(+) + thioredoxin = H(+) + NADPH + thioredoxin disulfide." [EC:1.8.1.9, RHEA:20348]
subset: gosubset_prok
synonym: "NADP--thioredoxin reductase activity" EXACT [EC:1.8.1.9]
synonym: "NADPH--thioredoxin reductase activity" EXACT [EC:1.8.1.9]
synonym: "NADPH2:oxidized thioredoxin oxidoreductase activity" EXACT [EC:1.8.1.9]
synonym: "NADPH:oxidized thioredoxin oxidoreductase activity" EXACT [EC:1.8.1.9]
synonym: "thioredoxin disulfide reductase activity" EXACT []
synonym: "thioredoxin reductase (NADPH) activity" EXACT []
synonym: "thioredoxin-disulphide reductase activity" EXACT []
synonym: "thioredoxin:NADP+ oxidoreductase activity" EXACT [EC:1.8.1.9]
xref: EC:1.8.1.9
xref: KEGG:R02016
xref: MetaCyc:THIOREDOXIN-REDUCT-NADPH-RXN
xref: Reactome:REACT_101101 "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+, Bos taurus"
xref: Reactome:REACT_102076 "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+, Taeniopygia guttata"
xref: Reactome:REACT_105790 "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+, Rattus norvegicus"
xref: Reactome:REACT_114582 "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+, Caenorhabditis elegans"
xref: Reactome:REACT_1609 "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+, Homo sapiens"
xref: Reactome:REACT_54247 "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+, Mus musculus"
xref: Reactome:REACT_79311 "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+, Gallus gallus"
xref: Reactome:REACT_88338 "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+, Sus scrofa"
xref: Reactome:REACT_94140 "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+, Canis familiaris"
xref: Reactome:REACT_97505 "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+, Xenopus tropicalis"
xref: RHEA:20348
is_a: GO:0016209 ! antioxidant activity
is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor

[Term]
id: GO:0004792
name: thiosulfate sulfurtransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrogen cyanide + thiosulfate = H(+) + sulfite + thiocyanate." [EC:2.8.1.1, RHEA:16884]
subset: gosubset_prok
synonym: "rhodanase activity" EXACT [EC:2.8.1.1]
synonym: "rhodanese activity" RELATED [EC:2.8.1.1]
synonym: "thiosulfate cyanide transsulfurase activity" EXACT [EC:2.8.1.1]
synonym: "thiosulfate thiotransferase activity" EXACT [EC:2.8.1.1]
synonym: "thiosulfate:cyanide sulfurtransferase activity" EXACT [EC:2.8.1.1]
synonym: "thiosulphate sulphurtransferase activity" EXACT []
xref: EC:2.8.1.1
xref: KEGG:R01931
xref: MetaCyc:THIOSULFATE-SULFURTRANSFERASE-RXN
xref: RHEA:16884
is_a: GO:0016783 ! sulfurtransferase activity

[Term]
id: GO:0004793
name: threonine aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-threonine = glycine + acetaldehyde." [EC:4.1.2.5]
subset: gosubset_prok
synonym: "L-threonine acetaldehyde-lyase (glycine-forming)" EXACT [EC:4.1.2.5]
synonym: "L-threonine acetaldehyde-lyase activity" EXACT [EC:4.1.2.5]
synonym: "L-threonine aldolase activity" EXACT []
xref: EC:4.1.2.5
xref: MetaCyc:THREONINE-ALDOLASE-RXN
xref: RHEA:19628
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0004794
name: L-threonine ammonia-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-threonine = 2-oxobutanoate + NH3." [EC:4.3.1.19]
comment: Note that this function was formerly EC:4.2.1.16.
subset: gosubset_prok
synonym: "L-serine dehydratase activity" RELATED [EC:4.3.1.19]
synonym: "L-threonine ammonia-lyase (2-oxobutanoate-forming)" EXACT [EC:4.3.1.19]
synonym: "L-threonine deaminase activity" EXACT [EC:4.3.1.19]
synonym: "L-threonine dehydratase activity" EXACT [EC:4.3.1.19]
synonym: "L-threonine hydro-lyase (deaminating) activity" EXACT [EC:4.3.1.19]
synonym: "serine deaminase activity" RELATED [EC:4.3.1.19]
synonym: "threonine ammonia-lyase activity" EXACT []
synonym: "threonine deaminase activity" EXACT [EC:4.3.1.19]
synonym: "threonine dehydrase activity" EXACT [EC:4.3.1.19]
synonym: "threonine dehydratase activity" EXACT []
xref: EC:4.3.1.19
xref: MetaCyc:THREDEHYD-RXN
xref: RHEA:22111
xref: UM-BBD_reactionID:r0433
is_a: GO:0016841 ! ammonia-lyase activity

[Term]
id: GO:0004795
name: threonine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: O-phospho-L-homoserine + H2O = L-threonine + phosphate." [EC:4.2.3.1]
subset: gosubset_prok
synonym: "O-phospho-L-homoserine phospho-lyase (adding water)" EXACT [EC:4.2.3.1]
synonym: "O-phospho-L-homoserine phospho-lyase (adding water; L-threonine-forming)" EXACT [EC:4.2.3.1]
synonym: "threonine synthetase activity" EXACT [EC:4.2.3.1]
xref: EC:4.2.3.1
xref: MetaCyc:THRESYN-RXN
xref: RHEA:10843
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0004796
name: thromboxane-A synthase activity
namespace: molecular_function
alt_id: GO:0008400
def: "Catalysis of the reaction: prostaglandin H(2) = thromboxane A(2)." [EC:5.3.99.5, RHEA:17140]
synonym: "(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate isomerase activity" EXACT [EC:5.3.99.5]
synonym: "(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate thromboxane-A2-isomerase activity" EXACT [EC:5.3.99.5]
synonym: "cytochrome P450 CYP5" NARROW []
synonym: "thromboxane synthase activity" EXACT [EC:5.3.99.5]
synonym: "thromboxane synthetase activity" EXACT [EC:5.3.99.5]
xref: EC:5.3.99.5
xref: KEGG:R02268
xref: MetaCyc:THROMBOXANE-A-SYNTHASE-RXN
xref: Reactome:REACT_105519 "Thromboxane synthase (CYP5A1) mediates the isomerization of prostaglandin H2 to thromboxane A2, Rattus norvegicus"
xref: Reactome:REACT_107129 "Thromboxane synthase (CYP5A1) mediates the isomerization of prostaglandin H2 to thromboxane A2, Mus musculus"
xref: Reactome:REACT_108523 "Thromboxane synthase (CYP5A1) mediates the isomerization of prostaglandin H2 to thromboxane A2, Gallus gallus"
xref: Reactome:REACT_109167 "Thromboxane synthase (CYP5A1) mediates the isomerization of prostaglandin H2 to thromboxane A2, Canis familiaris"
xref: Reactome:REACT_1377 "Thromboxane synthase (CYP5A1) mediates the isomerization of prostaglandin H2 to thromboxane A2, Homo sapiens"
xref: Reactome:REACT_28266 "Thromboxane synthase (CYP5A1) mediates the isomerization of prostaglandin H2 to thromboxane A2, Xenopus tropicalis"
xref: Reactome:REACT_30609 "Thromboxane synthase (CYP5A1) mediates the isomerization of prostaglandin H2 to thromboxane A2, Danio rerio"
xref: Reactome:REACT_81059 "Thromboxane synthase (CYP5A1) mediates the isomerization of prostaglandin H2 to thromboxane A2, Taeniopygia guttata"
xref: Reactome:REACT_92426 "Thromboxane synthase (CYP5A1) mediates the isomerization of prostaglandin H2 to thromboxane A2, Sus scrofa"
xref: Reactome:REACT_98585 "Thromboxane synthase (CYP5A1) mediates the isomerization of prostaglandin H2 to thromboxane A2, Bos taurus"
xref: RHEA:17140
is_a: GO:0016860 ! intramolecular oxidoreductase activity

[Term]
id: GO:0004797
name: thymidine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + thymidine = ADP + thymidine 5'-phosphate." [EC:2.7.1.21]
subset: gosubset_prok
synonym: "2'-deoxythymidine kinase activity" EXACT [EC:2.7.1.21]
synonym: "ATP:thymidine 5'-phosphotransferase activity" EXACT [EC:2.7.1.21]
synonym: "deoxythymidine kinase (phosphorylating)" EXACT [EC:2.7.1.21]
synonym: "thymidine kinase (phosphorylating)" EXACT [EC:2.7.1.21]
xref: EC:2.7.1.21
xref: MetaCyc:THYKI-RXN
xref: RHEA:19132
is_a: GO:0019136 ! deoxynucleoside kinase activity

[Term]
id: GO:0004798
name: thymidylate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate." [EC:2.7.4.9]
subset: gosubset_prok
synonym: "ATP:dTMP phosphotransferase activity" EXACT [EC:2.7.4.9]
synonym: "deoxythymidine 5'-monophosphate kinase activity" EXACT [EC:2.7.4.9]
synonym: "dTMP kinase activity" EXACT []
synonym: "thymidine 5'-monophosphate kinase activity" EXACT [EC:2.7.4.9]
synonym: "thymidine monophosphate kinase activity" EXACT [EC:2.7.4.9]
synonym: "thymidylate monophosphate kinase activity" EXACT [EC:2.7.4.9]
synonym: "thymidylic acid kinase activity" EXACT [EC:2.7.4.9]
synonym: "thymidylic kinase activity" EXACT [EC:2.7.4.9]
synonym: "TMPK activity" EXACT [EC:2.7.4.9]
xref: EC:2.7.4.9
xref: MetaCyc:DTMPKI-RXN
xref: RHEA:13520
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor
is_a: GO:0019201 ! nucleotide kinase activity

[Term]
id: GO:0004799
name: thymidylate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = 7,8-dihydrofolate + thymidylate." [EC:2.1.1.45, RHEA:12107]
subset: gosubset_prok
synonym: "5,10-methylenetetrahydrofolate:dUMP C-methyltransferase activity" EXACT [EC:2.1.1.45]
synonym: "dTMP synthase activity" EXACT [EC:2.1.1.45]
synonym: "methylenetetrahydrofolate:dUMP C-methyltransferase activity" EXACT [EC:2.1.1.45]
synonym: "thymidylate synthetase activity" EXACT [EC:2.1.1.45]
synonym: "TMP synthetase activity" EXACT [EC:2.1.1.45]
xref: EC:2.1.1.45
xref: KEGG:R02101
xref: MetaCyc:THYMIDYLATESYN-RXN
xref: Reactome:REACT_105743 "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate, Arabidopsis thaliana"
xref: Reactome:REACT_106949 "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate, Schizosaccharomyces pombe"
xref: Reactome:REACT_108055 "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate, Drosophila melanogaster"
xref: Reactome:REACT_108220 "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate, Mus musculus"
xref: Reactome:REACT_1679 "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate, Homo sapiens"
xref: Reactome:REACT_34727 "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate, Taeniopygia guttata"
xref: Reactome:REACT_78293 "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate, Danio rerio"
xref: Reactome:REACT_80685 "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate, Escherichia coli"
xref: Reactome:REACT_82204 "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate, Caenorhabditis elegans"
xref: Reactome:REACT_83275 "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate, Bos taurus"
xref: Reactome:REACT_86925 "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate, Mycobacterium tuberculosis"
xref: Reactome:REACT_90103 "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate, Xenopus tropicalis"
xref: Reactome:REACT_93781 "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate, Canis familiaris"
xref: Reactome:REACT_94977 "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate, Rattus norvegicus"
xref: Reactome:REACT_95603 "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate, Plasmodium falciparum"
xref: Reactome:REACT_95751 "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate, Oryza sativa"
xref: Reactome:REACT_96474 "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate, Saccharomyces cerevisiae"
xref: Reactome:REACT_96780 "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate, Gallus gallus"
xref: Reactome:REACT_97834 "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate, Staphylococcus aureus N315"
xref: RHEA:12107
is_a: GO:0042083 ! 5,10-methylenetetrahydrofolate-dependent methyltransferase activity

[Term]
id: GO:0004800
name: thyroxine 5'-deiodinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,5,3'-L-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + donor-H2." [EC:1.97.1.10]
comment: Note that this was EC:3.8.1.4.
synonym: "acceptor:3,5,3'-triiodo-L-thyronine oxidoreductase (iodinating)" EXACT [EC:1.97.1.10]
synonym: "diiodothyronine 5'-deiodinase activity" EXACT [EC:1.97.1.10]
synonym: "iodothyronine 5'-deiodinase activity" EXACT [EC:1.97.1.10]
synonym: "iodothyronine outer ring monodeiodinase activity" EXACT [EC:1.97.1.10]
synonym: "L-thyroxine iodohydrolase (reducing) activity" EXACT [EC:1.97.1.10]
synonym: "outer ring-deiodinating pathway" EXACT [PMID:20403357]
synonym: "thyroxine 5' deiodinase activity" EXACT []
synonym: "thyroxine deiodinase activity" BROAD []
synonym: "type I iodothyronine deiodinase activity" NARROW [EC:1.97.1.10]
synonym: "type II iodothyronine deiodinase activity" NARROW [EC:1.97.1.10]
xref: EC:1.97.1.10
xref: MetaCyc:THYROXINE-DEIODINASE-RXN
xref: Reactome:REACT_101070 "Thyroxine is deiodinated to reverse triiodothyronine (RT3), Taeniopygia guttata"
xref: Reactome:REACT_106668 "Thyroxine is deiodinated to reverse triiodothyronine (RT3), Bos taurus"
xref: Reactome:REACT_15469 "Thyroxine is deiodinated to triiodothyronine, Homo sapiens"
xref: Reactome:REACT_15528 "Thyroxine is deiodinated to reverse triiodothyronine (RT3), Homo sapiens"
xref: Reactome:REACT_29089 "Thyroxine is deiodinated to reverse triiodothyronine (RT3), Sus scrofa"
xref: Reactome:REACT_30839 "Thyroxine is deiodinated to triiodothyronine, Bos taurus"
xref: Reactome:REACT_32482 "Thyroxine is deiodinated to triiodothyronine, Rattus norvegicus"
xref: Reactome:REACT_77772 "Thyroxine is deiodinated to triiodothyronine, Gallus gallus"
xref: Reactome:REACT_81783 "Thyroxine is deiodinated to reverse triiodothyronine (RT3), Gallus gallus"
xref: Reactome:REACT_81828 "Thyroxine is deiodinated to reverse triiodothyronine (RT3), Mus musculus"
xref: Reactome:REACT_83155 "Thyroxine is deiodinated to triiodothyronine, Taeniopygia guttata"
xref: Reactome:REACT_85931 "Thyroxine is deiodinated to triiodothyronine, Mus musculus"
xref: Reactome:REACT_87369 "Thyroxine is deiodinated to triiodothyronine, Canis familiaris"
xref: Reactome:REACT_91419 "Thyroxine is deiodinated to reverse triiodothyronine (RT3), Xenopus tropicalis"
xref: Reactome:REACT_93038 "Thyroxine is deiodinated to reverse triiodothyronine (RT3), Dictyostelium discoideum"
xref: Reactome:REACT_97119 "Thyroxine is deiodinated to reverse triiodothyronine (RT3), Canis familiaris"
xref: Reactome:REACT_98784 "Thyroxine is deiodinated to reverse triiodothyronine (RT3), Danio rerio"
xref: Reactome:REACT_99112 "Thyroxine is deiodinated to triiodothyronine, Danio rerio"
xref: Reactome:REACT_99930 "Thyroxine is deiodinated to triiodothyronine, Dictyostelium discoideum"
xref: RHEA:19748
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0004801
name: sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate." [EC:2.2.1.2]
subset: gosubset_prok
synonym: "dihydroxyacetone transferase activity" BROAD [EC:2.2.1.2]
synonym: "dihydroxyacetonetransferase activity" BROAD [EC:2.2.1.2]
synonym: "glycerone transferase activity" BROAD [EC:2.2.1.2]
synonym: "transaldolase activity" BROAD [EC:2.2.1.2]
xref: EC:2.2.1.2
xref: MetaCyc:TRANSALDOL-RXN
xref: Reactome:REACT_100775 "D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_103519 "D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate, Rattus norvegicus"
xref: Reactome:REACT_104310 "D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate, Danio rerio"
xref: Reactome:REACT_104399 "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_105033 "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate, Taeniopygia guttata"
xref: Reactome:REACT_105572 "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate, Xenopus tropicalis"
xref: Reactome:REACT_105812 "D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_107699 "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate, Caenorhabditis elegans"
xref: Reactome:REACT_110840 "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate, Arabidopsis thaliana"
xref: Reactome:REACT_1272 "D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate, Homo sapiens"
xref: Reactome:REACT_28702 "D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate, Xenopus tropicalis"
xref: Reactome:REACT_30105 "D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate, Caenorhabditis elegans"
xref: Reactome:REACT_32161 "D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate, Oryza sativa"
xref: Reactome:REACT_32987 "D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate, Gallus gallus"
xref: Reactome:REACT_34347 "D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate, Arabidopsis thaliana"
xref: Reactome:REACT_479 "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate, Homo sapiens"
xref: Reactome:REACT_77803 "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate, Oryza sativa"
xref: Reactome:REACT_79737 "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate, Danio rerio"
xref: Reactome:REACT_81998 "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_82843 "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate, Rattus norvegicus"
xref: Reactome:REACT_83808 "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate, Dictyostelium discoideum"
xref: Reactome:REACT_87548 "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate, Mus musculus"
xref: Reactome:REACT_89226 "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate, Bos taurus"
xref: Reactome:REACT_89922 "D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate, Canis familiaris"
xref: Reactome:REACT_90344 "D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate, Bos taurus"
xref: Reactome:REACT_90500 "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate, Gallus gallus"
xref: Reactome:REACT_91317 "D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate, Dictyostelium discoideum"
xref: Reactome:REACT_93707 "D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate, Taeniopygia guttata"
xref: Reactome:REACT_94030 "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate, Canis familiaris"
xref: Reactome:REACT_95141 "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate, Sus scrofa"
xref: Reactome:REACT_95588 "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate, Drosophila melanogaster"
xref: Reactome:REACT_96463 "D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate, Sus scrofa"
xref: Reactome:REACT_97584 "D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate, Drosophila melanogaster"
xref: Reactome:REACT_98795 "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate, Escherichia coli"
xref: Reactome:REACT_98977 "D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate, Escherichia coli"
xref: Reactome:REACT_99333 "D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate, Mus musculus"
xref: RHEA:17056
is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups

[Term]
id: GO:0004802
name: transketolase activity
namespace: molecular_function
def: "Catalysis of the reversible transfer of a 2-carbon ketol group (CH2OH-CO-) from a ketose phosphate donor to an aldose phosphate acceptor." [EC:2.2.1.1, GOC:fmc]
subset: gosubset_prok
synonym: "fructose 6-phosphate:D-glyceraldehyde-3-phosphate glycolaldehydetransferase activity" NARROW [GOC:fmc, GOC:mah]
synonym: "glycoaldehyde transferase activity" EXACT [EC:2.2.1.1]
synonym: "glycolaldehydetransferase activity" EXACT [EC:2.2.1.1]
synonym: "sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glycolaldehydetransferase activity" NARROW [EC:2.2.1.1]
xref: EC:2.2.1.1
xref: MetaCyc:1TRANSKETO-RXN
xref: Reactome:REACT_100228 "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate, Danio rerio"
xref: Reactome:REACT_100510 "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate, Canis familiaris"
xref: Reactome:REACT_101413 "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate <=> xylulose 5-phosphate + D-erythrose 4-phosphate, Caenorhabditis elegans"
xref: Reactome:REACT_101444 "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate, Taeniopygia guttata"
xref: Reactome:REACT_101917 "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate, Caenorhabditis elegans"
xref: Reactome:REACT_102210 "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate, Canis familiaris"
xref: Reactome:REACT_102666 "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate, Caenorhabditis elegans"
xref: Reactome:REACT_104207 "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate, Caenorhabditis elegans"
xref: Reactome:REACT_104498 "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate, Gallus gallus"
xref: Reactome:REACT_104804 "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate, Gallus gallus"
xref: Reactome:REACT_109880 "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate, Taeniopygia guttata"
xref: Reactome:REACT_1450 "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate, Homo sapiens"
xref: Reactome:REACT_1629 "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate, Homo sapiens"
xref: Reactome:REACT_1730 "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate <=> xylulose 5-phosphate + D-erythrose 4-phosphate, Homo sapiens"
xref: Reactome:REACT_1811 "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate, Homo sapiens"
xref: Reactome:REACT_29338 "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate, Danio rerio"
xref: Reactome:REACT_29870 "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate, Mus musculus"
xref: Reactome:REACT_30597 "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate, Xenopus tropicalis"
xref: Reactome:REACT_30952 "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate, Mus musculus"
xref: Reactome:REACT_33085 "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate, Danio rerio"
xref: Reactome:REACT_77046 "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate, Mus musculus"
xref: Reactome:REACT_77603 "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate <=> xylulose 5-phosphate + D-erythrose 4-phosphate, Danio rerio"
xref: Reactome:REACT_78995 "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate, Rattus norvegicus"
xref: Reactome:REACT_79035 "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate <=> xylulose 5-phosphate + D-erythrose 4-phosphate, Xenopus tropicalis"
xref: Reactome:REACT_80449 "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate <=> xylulose 5-phosphate + D-erythrose 4-phosphate, Canis familiaris"
xref: Reactome:REACT_81342 "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate, Rattus norvegicus"
xref: Reactome:REACT_82295 "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate, Bos taurus"
xref: Reactome:REACT_83263 "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate, Bos taurus"
xref: Reactome:REACT_83842 "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate, Xenopus tropicalis"
xref: Reactome:REACT_84066 "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate <=> xylulose 5-phosphate + D-erythrose 4-phosphate, Drosophila melanogaster"
xref: Reactome:REACT_86446 "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate, Drosophila melanogaster"
xref: Reactome:REACT_86520 "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate, Canis familiaris"
xref: Reactome:REACT_89058 "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate, Rattus norvegicus"
xref: Reactome:REACT_89164 "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate, Gallus gallus"
xref: Reactome:REACT_91651 "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate <=> xylulose 5-phosphate + D-erythrose 4-phosphate, Gallus gallus"
xref: Reactome:REACT_92024 "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate <=> xylulose 5-phosphate + D-erythrose 4-phosphate, Taeniopygia guttata"
xref: Reactome:REACT_92238 "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate <=> xylulose 5-phosphate + D-erythrose 4-phosphate, Rattus norvegicus"
xref: Reactome:REACT_95184 "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate, Drosophila melanogaster"
xref: Reactome:REACT_95554 "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate <=> xylulose 5-phosphate + D-erythrose 4-phosphate, Mus musculus"
xref: Reactome:REACT_95844 "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate, Xenopus tropicalis"
xref: Reactome:REACT_96065 "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate, Taeniopygia guttata"
xref: Reactome:REACT_96598 "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate, Bos taurus"
xref: Reactome:REACT_96933 "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate, Drosophila melanogaster"
xref: Reactome:REACT_98793 "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate <=> xylulose 5-phosphate + D-erythrose 4-phosphate, Bos taurus"
is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups

[Term]
id: GO:0004803
name: transposase activity
namespace: molecular_function
alt_id: GO:0004804
def: "Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element." [GOC:bm, ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
synonym: "P-element encoded transposase activity" NARROW []
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0004805
name: trehalose-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: trehalose 6-phosphate + H2O = trehalose + phosphate." [EC:3.1.3.12]
subset: gosubset_prok
synonym: "trehalose 6-phosphatase activity" EXACT [EC:3.1.3.12]
synonym: "trehalose 6-phosphate phosphatase activity" EXACT [EC:3.1.3.12]
synonym: "trehalose phosphatase activity" EXACT []
synonym: "trehalose-6-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.12]
xref: EC:3.1.3.12
xref: MetaCyc:TREHALOSEPHOSPHA-RXN
xref: Reactome:REACT_27176 "Trehalose-6-phosphate is hydrolyzed to trehalose, Mycobacterium tuberculosis"
xref: RHEA:23423
is_a: GO:0019203 ! carbohydrate phosphatase activity

[Term]
id: GO:0004806
name: triglyceride lipase activity
namespace: molecular_function
def: "Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate." [EC:3.1.1.3]
subset: goslim_chembl
subset: gosubset_prok
synonym: "amano AP" RELATED [EC:3.1.1.3]
synonym: "amano B" RELATED [EC:3.1.1.3]
synonym: "amano CE" RELATED [EC:3.1.1.3]
synonym: "amano CES" RELATED [EC:3.1.1.3]
synonym: "amano P" RELATED [EC:3.1.1.3]
synonym: "amno N-AP" RELATED [EC:3.1.1.3]
synonym: "butyrinase activity" EXACT [EC:3.1.1.3]
synonym: "cacordase activity" EXACT [EC:3.1.1.3]
synonym: "capalase L" RELATED [EC:3.1.1.3]
synonym: "GA 56" RELATED [EC:3.1.1.3]
synonym: "GEH" RELATED [EC:3.1.1.3]
synonym: "glycerol ester hydrolase activity" EXACT [EC:3.1.1.3]
synonym: "glycerol-ester hydrolase activity" EXACT [EC:3.1.1.3]
synonym: "heparin releasable hepatic lipase" NARROW [EC:3.1.1.3]
synonym: "hepatic lipase" NARROW [EC:3.1.1.3]
synonym: "hepatic monoacylglycerol acyltransferase" NARROW [EC:3.1.1.3]
synonym: "lipazin" RELATED [EC:3.1.1.3]
synonym: "liver lipase" NARROW [EC:3.1.1.3]
synonym: "meito MY 30" RELATED [EC:3.1.1.3]
synonym: "meito sangyo OF lipase" RELATED [EC:3.1.1.3]
synonym: "post-heparin plasma protamine-resistant lipase" NARROW [EC:3.1.1.3]
synonym: "PPL" RELATED [EC:3.1.1.3]
synonym: "salt-resistant post-heparin lipase" NARROW [EC:3.1.1.3]
synonym: "steapsin" RELATED [EC:3.1.1.3]
synonym: "takedo 1969-4-9" RELATED [EC:3.1.1.3]
synonym: "triacetinase activity" EXACT [EC:3.1.1.3]
synonym: "triacylglycerol acylhydrolase activity" EXACT [EC:3.1.1.3]
synonym: "triacylglycerol ester hydrolase activity" EXACT [EC:3.1.1.3]
synonym: "triacylglycerol lipase activity" EXACT [EC:3.1.1.3]
synonym: "tributyrase activity" RELATED [EC:3.1.1.3]
synonym: "tributyrin esterase activity" EXACT [EC:3.1.1.3]
synonym: "tributyrinase activity" EXACT [EC:3.1.1.3]
synonym: "triglyceridase activity" EXACT [EC:3.1.1.3]
synonym: "triglyceride hydrolase activity" EXACT [EC:3.1.1.3]
synonym: "triolein hydrolase activity" EXACT [EC:3.1.1.3]
synonym: "tween hydrolase activity" EXACT [EC:3.1.1.3]
synonym: "tween-hydrolyzing esterase activity" EXACT [EC:3.1.1.3]
synonym: "tweenase activity" EXACT [EC:3.1.1.3]
synonym: "tweenesterase activity" EXACT [EC:3.1.1.3]
xref: EC:3.1.1.3
xref: MetaCyc:TRIACYLGLYCEROL-LIPASE-RXN
xref: Reactome:REACT_100562 "triacylglycerol + H2O -> diacylglycerol + fatty acid, Caenorhabditis elegans"
xref: Reactome:REACT_109925 "triacylglycerol + H2O -> diacylglycerol + fatty acid, Canis familiaris"
xref: Reactome:REACT_113800 "triacylglycerol + H2O -> diacylglycerol + fatty acid, Danio rerio"
xref: Reactome:REACT_1694 "triacylglycerol + H2O -> diacylglycerol + fatty acid, Rattus norvegicus"
xref: Reactome:REACT_34739 "triacylglycerol + H2O -> diacylglycerol + fatty acid, Bos taurus"
xref: Reactome:REACT_538 "triacylglycerol + H2O -> diacylglycerol + fatty acid, Homo sapiens"
xref: Reactome:REACT_77800 "triacylglycerol + H2O -> diacylglycerol + fatty acid, Mus musculus"
xref: Reactome:REACT_92207 "triacylglycerol + H2O -> diacylglycerol + fatty acid, Xenopus tropicalis"
xref: RHEA:12047
is_a: GO:0016298 ! lipase activity
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0004807
name: triose-phosphate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate = glycerone phosphate." [EC:5.3.1.1, RHEA:18588]
subset: gosubset_prok
synonym: "D-glyceraldehyde-3-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.1]
synonym: "D-glyceraldehyde-3-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.1]
synonym: "phosphotriose isomerase activity" EXACT [EC:5.3.1.1]
synonym: "triose phosphate mutase activity" EXACT [EC:5.3.1.1]
synonym: "triose phosphoisomerase activity" EXACT [EC:5.3.1.1]
synonym: "triosephosphate isomerase activity" EXACT [EC:5.3.1.1]
synonym: "triosephosphate mutase activity" EXACT [EC:5.3.1.1]
xref: EC:5.3.1.1
xref: KEGG:R01015
xref: MetaCyc:TRIOSEPISOMERIZATION-RXN
xref: Reactome:REACT_104480 "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_104869 "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate, Canis familiaris"
xref: Reactome:REACT_104997 "D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_105210 "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate, Rattus norvegicus"
xref: Reactome:REACT_105711 "D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate, Sus scrofa"
xref: Reactome:REACT_106006 "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate, Gallus gallus"
xref: Reactome:REACT_108615 "D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate, Rattus norvegicus"
xref: Reactome:REACT_111026 "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate, Sus scrofa"
xref: Reactome:REACT_115710 "glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate, Gallus gallus"
xref: Reactome:REACT_116062 "dihydroxyacetone phosphate <=> glyceraldehyde 3-phosphate, Gallus gallus"
xref: Reactome:REACT_28554 "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate, Danio rerio"
xref: Reactome:REACT_28710 "D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate, Gallus gallus"
xref: Reactome:REACT_28815 "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate, Mycobacterium tuberculosis"
xref: Reactome:REACT_30724 "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate, Plasmodium falciparum"
xref: Reactome:REACT_32420 "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_34299 "D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate, Canis familiaris"
xref: Reactome:REACT_469 "D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate, Homo sapiens"
xref: Reactome:REACT_76931 "D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate, Staphylococcus aureus N315"
xref: Reactome:REACT_77133 "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate, Mus musculus"
xref: Reactome:REACT_775 "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate, Homo sapiens"
xref: Reactome:REACT_78276 "D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate, Plasmodium falciparum"
xref: Reactome:REACT_80367 "D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate, Escherichia coli"
xref: Reactome:REACT_80397 "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate, Caenorhabditis elegans"
xref: Reactome:REACT_80581 "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate, Xenopus tropicalis"
xref: Reactome:REACT_82506 "D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate, Bos taurus"
xref: Reactome:REACT_82636 "D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate, Mus musculus"
xref: Reactome:REACT_82662 "D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate, Xenopus tropicalis"
xref: Reactome:REACT_83352 "D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate, Drosophila melanogaster"
xref: Reactome:REACT_83395 "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate, Drosophila melanogaster"
xref: Reactome:REACT_85037 "D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate, Caenorhabditis elegans"
xref: Reactome:REACT_85223 "D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate, Mycobacterium tuberculosis"
xref: Reactome:REACT_86707 "D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate, Danio rerio"
xref: Reactome:REACT_90699 "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate, Staphylococcus aureus N315"
xref: Reactome:REACT_94116 "D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_95650 "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate, Escherichia coli"
xref: Reactome:REACT_95863 "D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate, Dictyostelium discoideum"
xref: Reactome:REACT_95932 "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate, Bos taurus"
xref: Reactome:REACT_96249 "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate, Dictyostelium discoideum"
xref: RHEA:18588
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0004808
name: tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
namespace: molecular_function
alt_id: GO:0016425
def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing 5-aminomethyl-2-thiouridine = S-adenosyl-L-homocysteine + tRNA containing 5-methylaminomethyl-2-thiouridylate." [EC:2.1.1.61, GOC:imk]
subset: gosubset_prok
synonym: "S-adenosyl-L-methionine:tRNA (5-methylaminomethyl-2-thio-uridylate)-methyltransferase activity" EXACT [EC:2.1.1.61]
synonym: "transfer ribonucleate 5-methylaminomethyl-2-thiouridylate 5-methyltransferase activity" EXACT [EC:2.1.1.61]
synonym: "tRNA 5-methylaminomethyl-2-thiouridylate 5'-methyltransferase activity" EXACT [EC:2.1.1.61]
xref: EC:2.1.1.61
xref: KEGG:R00601
xref: MetaCyc:2.1.1.61-RXN
is_a: GO:0008175 ! tRNA methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0004809
name: tRNA (guanine-N2-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing guanine = S-adenosyl-L-homocysteine + tRNA containing N2-methylguanine." [EC:2.1.1.32]
subset: gosubset_prok
synonym: "guanine-N2-methylase activity" EXACT [EC:2.1.1.32]
synonym: "N(2),N(2)-dimethylguanine tRNA methyltransferase activity" EXACT [EC:2.1.1.32]
synonym: "N2,N2-dimethylguanine tRNA methyltransferase activity" EXACT [EC:2.1.1.32]
synonym: "S-adenosyl-L-methionine:tRNA (guanine-2-N-)-methyltransferase activity" EXACT [EC:2.1.1.32]
synonym: "S-adenosyl-L-methionine:tRNA (guanine-N2-)-methyltransferase activity" EXACT [EC:2.1.1.32]
synonym: "transfer ribonucleate guanine 2-methyltransferase activity" EXACT [EC:2.1.1.32]
synonym: "transfer ribonucleate guanine N2-methyltransferase activity" EXACT [EC:2.1.1.32]
synonym: "transfer RNA guanine 2-methyltransferase activity" EXACT [EC:2.1.1.32]
synonym: "tRNA 2,2-dimethylguanosine-26 methyltransferase activity" EXACT [EC:2.1.1.32]
synonym: "tRNA(guanine-26,N(2)-N(2)) methyltransferase activity" EXACT [EC:2.1.1.32]
synonym: "tRNA(guanine-26,N2-N2) methyltransferase activity" EXACT [EC:2.1.1.32]
synonym: "tRNA(m(2,2)G26)dimethyltransferase activity" EXACT [EC:2.1.1.32]
xref: EC:2.1.1.-
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0016423 ! tRNA (guanine) methyltransferase activity

[Term]
id: GO:0004810
name: tRNA adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + tRNA(n) = diphosphate + tRNA(n+1)." [EC:2.7.7.25]
comment: This term represents a deleted EC activity and is scheduled for obsoletion.
subset: mf_needs_review
synonym: "-C-C-A pyrophosphorylase" BROAD [EC:2.7.7.25]
synonym: "ATP (CTP):tRNA nucleotidyltransferase" BROAD [EC:2.7.7.25]
synonym: "ATP(CTP)-tRNA nucleotidyltransferase" BROAD [EC:2.7.7.25]
synonym: "ATP:tRNA adenylyltransferase activity" EXACT []
synonym: "CCA-adding enzyme activity" RELATED [EC:2.7.7.25]
synonym: "CTP(ATP):tRNA nucleotidyltransferase" BROAD [EC:2.7.7.25]
synonym: "ribonucleic cytidylic cytidylic adenylic pyrophosphorylase" BROAD [EC:2.7.7.25]
synonym: "ribonucleic cytidylyltransferase" BROAD [EC:2.7.7.25]
synonym: "transfer ribonucleate adenyltransferase activity" EXACT [EC:2.7.7.25]
synonym: "transfer ribonucleate adenylyltransferase" BROAD [EC:2.7.7.25]
synonym: "transfer ribonucleate cytidylyltransferase" BROAD [EC:2.7.7.25]
synonym: "transfer ribonucleate nucleotidyltransferase" BROAD [EC:2.7.7.25]
synonym: "transfer ribonucleic acid nucleotidyl transferase" BROAD [EC:2.7.7.25]
synonym: "transfer ribonucleic adenylyl (cytidylyl) transferase" BROAD [EC:2.7.7.25]
synonym: "transfer ribonucleic-terminal trinucleotide nucleotidyltransferase" BROAD [EC:2.7.7.25]
synonym: "transfer RNA adenylyltransferase" BROAD [EC:2.7.7.25]
synonym: "transfer-RNA nucleotidyltransferase" BROAD [EC:2.7.7.25]
synonym: "tRNA adenylyl(cytidylyl)transferase" BROAD [EC:2.7.7.25]
synonym: "tRNA CCA-diphosphorylase activity" RELATED [EC:2.7.7.25]
synonym: "tRNA CCA-pyrophosphorylase activity" RELATED [EC:2.7.7.25]
synonym: "tRNA-nucleotidyltransferase activity" BROAD [EC:2.7.7.25]
xref: EC:2.7.7.25
xref: MetaCyc:TRNA-ADENYLYLTRANSFERASE-RXN
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0004812
name: aminoacyl-tRNA ligase activity
namespace: molecular_function
alt_id: GO:0017100
def: "Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]
comment: Note that the bond resulting from this reaction is a carboxylic acid ester bond, linking the alpha carboxyl group of the amino acid to either the 2' or 3' hydroxyl of the 3'- terminal adenyl residue of the tRNA.
subset: goslim_metagenomics
subset: gosubset_prok
synonym: "aminoacyl-tRNA synthetase activity" EXACT [GOC:hjd]
synonym: "aminoacyl-tRNA synthetase auxiliary protein activity" RELATED []
xref: EC:6.1.1.-
is_a: GO:0016876 ! ligase activity, forming aminoacyl-tRNA and related compounds

[Term]
id: GO:0004813
name: alanine-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)." [EC:6.1.1.7]
subset: gosubset_prok
synonym: "Ala-tRNA synthetase activity" EXACT [EC:6.1.1.7]
synonym: "alanine transfer RNA synthetase activity" EXACT [EC:6.1.1.7]
synonym: "alanine translase activity" EXACT [EC:6.1.1.7]
synonym: "alanine tRNA synthetase activity" EXACT [EC:6.1.1.7]
synonym: "alanine-transfer RNA ligase activity" EXACT [EC:6.1.1.7]
synonym: "alanyl-transfer ribonucleate synthase activity" EXACT [EC:6.1.1.7]
synonym: "alanyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.7]
synonym: "alanyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.7]
synonym: "alanyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.7]
synonym: "alanyl-tRNA synthetase activity" EXACT []
synonym: "AlaRS" RELATED [EC:6.1.1.7]
synonym: "L-alanine:tRNAAla ligase (AMP-forming)" EXACT [EC:6.1.1.7]
xref: EC:6.1.1.7
xref: MetaCyc:ALANINE--TRNA-LIGASE-RXN
xref: Reactome:REACT_100758 "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate, Sus scrofa"
xref: Reactome:REACT_100931 "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate, Rattus norvegicus"
xref: Reactome:REACT_101510 "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_103189 "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate, Bos taurus"
xref: Reactome:REACT_104077 "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate, Taeniopygia guttata"
xref: Reactome:REACT_105308 "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate, Plasmodium falciparum"
xref: Reactome:REACT_107108 "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate, Danio rerio"
xref: Reactome:REACT_112870 "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate, Staphylococcus aureus N315"
xref: Reactome:REACT_112886 "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate, Caenorhabditis elegans"
xref: Reactome:REACT_113119 "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate, Oryza sativa"
xref: Reactome:REACT_114744 "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate, Arabidopsis thaliana"
xref: Reactome:REACT_114834 "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate, Arabidopsis thaliana"
xref: Reactome:REACT_114863 "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate, Drosophila melanogaster"
xref: Reactome:REACT_114945 "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate, Oryza sativa"
xref: Reactome:REACT_15409 "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate, Homo sapiens"
xref: Reactome:REACT_15463 "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate, Homo sapiens"
xref: Reactome:REACT_29549 "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_29946 "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate, Plasmodium falciparum"
xref: Reactome:REACT_31167 "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate, Danio rerio"
xref: Reactome:REACT_31941 "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate, Gallus gallus"
xref: Reactome:REACT_33807 "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate, Caenorhabditis elegans"
xref: Reactome:REACT_77349 "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_79072 "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate, Sus scrofa"
xref: Reactome:REACT_79767 "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate, Canis familiaris"
xref: Reactome:REACT_81623 "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate, Canis familiaris"
xref: Reactome:REACT_81808 "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate, Mus musculus"
xref: Reactome:REACT_81827 "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate, Drosophila melanogaster"
xref: Reactome:REACT_82084 "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_85761 "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_89033 "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate, Gallus gallus"
xref: Reactome:REACT_89789 "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate, Bos taurus"
xref: Reactome:REACT_91793 "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate, Rattus norvegicus"
xref: Reactome:REACT_96642 "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate, Mus musculus"
xref: Reactome:REACT_98178 "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate, Xenopus tropicalis"
xref: Reactome:REACT_98684 "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate, Taeniopygia guttata"
xref: Reactome:REACT_99942 "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate, Dictyostelium discoideum"
xref: RHEA:12543
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004814
name: arginine-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)." [EC:6.1.1.19]
subset: gosubset_prok
synonym: "arginine translase activity" EXACT [EC:6.1.1.19]
synonym: "arginine-tRNA synthetase activity" EXACT [EC:6.1.1.19]
synonym: "arginyl transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.19]
synonym: "arginyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.19]
synonym: "arginyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.19]
synonym: "arginyl-tRNA synthetase activity" EXACT []
synonym: "L-arginine:tRNAArg ligase (AMP-forming)" EXACT [EC:6.1.1.19]
xref: EC:6.1.1.19
xref: MetaCyc:ARGININE--TRNA-LIGASE-RXN
xref: Reactome:REACT_100308 "arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate, Gallus gallus"
xref: Reactome:REACT_100953 "arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate, Sus scrofa"
xref: Reactome:REACT_101377 "arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate, Bos taurus"
xref: Reactome:REACT_101598 "arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate, Taeniopygia guttata"
xref: Reactome:REACT_101912 "arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_107098 "arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_108427 "arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate, Taeniopygia guttata"
xref: Reactome:REACT_108832 "arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate, Sus scrofa"
xref: Reactome:REACT_110984 "arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate, Xenopus tropicalis"
xref: Reactome:REACT_114854 "arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate, Arabidopsis thaliana"
xref: Reactome:REACT_15489 "arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate, Homo sapiens"
xref: Reactome:REACT_15544 "arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate, Homo sapiens"
xref: Reactome:REACT_28070 "arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate, Xenopus tropicalis"
xref: Reactome:REACT_31385 "arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate, Drosophila melanogaster"
xref: Reactome:REACT_32184 "arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_32510 "arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate, Drosophila melanogaster"
xref: Reactome:REACT_77308 "arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate, Danio rerio"
xref: Reactome:REACT_80003 "arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate, Canis familiaris"
xref: Reactome:REACT_80388 "arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate, Mus musculus"
xref: Reactome:REACT_81536 "arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate, Rattus norvegicus"
xref: Reactome:REACT_83921 "arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate, Mus musculus"
xref: Reactome:REACT_89016 "arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate, Caenorhabditis elegans"
xref: Reactome:REACT_91111 "arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_93321 "arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate, Oryza sativa"
xref: Reactome:REACT_94307 "arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate, Rattus norvegicus"
xref: Reactome:REACT_97324 "arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate, Canis familiaris"
xref: Reactome:REACT_97666 "arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate, Bos taurus"
xref: Reactome:REACT_99731 "arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate, Danio rerio"
xref: Reactome:REACT_99751 "arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate, Gallus gallus"
xref: RHEA:20304
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004815
name: aspartate-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)." [EC:6.1.1.12]
subset: gosubset_prok
synonym: "aspartic acid translase activity" EXACT [EC:6.1.1.12]
synonym: "aspartyl ribonucleate synthetase activity" EXACT [EC:6.1.1.12]
synonym: "aspartyl ribonucleic synthetase activity" EXACT [EC:6.1.1.12]
synonym: "aspartyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.12]
synonym: "aspartyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.12]
synonym: "aspartyl-tRNA synthetase activity" EXACT []
synonym: "L-aspartate:tRNAAsp ligase (AMP-forming)" EXACT [EC:6.1.1.12]
xref: EC:6.1.1.12
xref: MetaCyc:ASPARTATE--TRNA-LIGASE-RXN
xref: Reactome:REACT_100230 "aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate, Mus musculus"
xref: Reactome:REACT_102065 "aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate, Canis familiaris"
xref: Reactome:REACT_104722 "aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate, Mus musculus"
xref: Reactome:REACT_107319 "aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate, Gallus gallus"
xref: Reactome:REACT_107512 "aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate, Arabidopsis thaliana"
xref: Reactome:REACT_107648 "aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate, Caenorhabditis elegans"
xref: Reactome:REACT_107709 "aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate, Xenopus tropicalis"
xref: Reactome:REACT_107988 "aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate, Bos taurus"
xref: Reactome:REACT_109303 "aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate, Taeniopygia guttata"
xref: Reactome:REACT_109505 "aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_110506 "aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate, Staphylococcus aureus N315"
xref: Reactome:REACT_112613 "aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate, Arabidopsis thaliana"
xref: Reactome:REACT_15346 "aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate, Homo sapiens"
xref: Reactome:REACT_15437 "aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate, Homo sapiens"
xref: Reactome:REACT_30480 "aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate, Gallus gallus"
xref: Reactome:REACT_31439 "aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate, Bos taurus"
xref: Reactome:REACT_32576 "aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate, Danio rerio"
xref: Reactome:REACT_61623 "aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate, Canis familiaris"
xref: Reactome:REACT_77414 "aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_77484 "aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate, Xenopus tropicalis"
xref: Reactome:REACT_81523 "aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate, Sus scrofa"
xref: Reactome:REACT_83127 "aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate, Danio rerio"
xref: Reactome:REACT_83892 "aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate, Drosophila melanogaster"
xref: Reactome:REACT_85816 "aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate, Oryza sativa"
xref: Reactome:REACT_86019 "aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate, Rattus norvegicus"
xref: Reactome:REACT_86234 "aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate, Sus scrofa"
xref: Reactome:REACT_86590 "aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate, Taeniopygia guttata"
xref: Reactome:REACT_89609 "aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate, Drosophila melanogaster"
xref: Reactome:REACT_93154 "aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_93789 "aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate, Mycobacterium tuberculosis"
xref: Reactome:REACT_93900 "aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate, Escherichia coli"
xref: Reactome:REACT_93962 "aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate, Oryza sativa"
xref: Reactome:REACT_94027 "aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_99150 "aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate, Rattus norvegicus"
xref: RHEA:19652
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004816
name: asparagine-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-asparagine + ATP + tRNA(Asn) = AMP + Asn-tRNA(Asn) + diphosphate + 2 H(+)." [EC:6.1.1.22, RHEA:11183]
subset: gosubset_prok
synonym: "asparagine translase activity" EXACT [EC:6.1.1.22]
synonym: "asparaginyl transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.22]
synonym: "asparaginyl transfer RNA synthetase activity" EXACT [EC:6.1.1.22]
synonym: "asparaginyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.22]
synonym: "asparaginyl-tRNA synthetase activity" EXACT []
synonym: "asparagyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.22]
synonym: "L-asparagine:tRNAAsn ligase (AMP-forming)" EXACT [EC:6.1.1.22]
xref: EC:6.1.1.22
xref: KEGG:R03648
xref: MetaCyc:ASPARAGINE--TRNA-LIGASE-RXN
xref: Reactome:REACT_101019 "asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_101935 "asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate, Taeniopygia guttata"
xref: Reactome:REACT_101973 "asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate, Sus scrofa"
xref: Reactome:REACT_103776 "asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_105044 "asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate, Canis familiaris"
xref: Reactome:REACT_105185 "asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate, Arabidopsis thaliana"
xref: Reactome:REACT_105333 "asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate, Plasmodium falciparum"
xref: Reactome:REACT_106362 "asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate, Bos taurus"
xref: Reactome:REACT_108425 "asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate, Taeniopygia guttata"
xref: Reactome:REACT_115176 "asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate, Staphylococcus aureus N315"
xref: Reactome:REACT_15340 "asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate, Homo sapiens"
xref: Reactome:REACT_15414 "asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate, Homo sapiens"
xref: Reactome:REACT_28424 "asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate, Escherichia coli"
xref: Reactome:REACT_30748 "asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate, Caenorhabditis elegans"
xref: Reactome:REACT_33251 "asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate, Gallus gallus"
xref: Reactome:REACT_33630 "asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_33867 "asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate, Bos taurus"
xref: Reactome:REACT_79777 "asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate, Drosophila melanogaster"
xref: Reactome:REACT_80824 "asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate, Mus musculus"
xref: Reactome:REACT_82671 "asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate, Rattus norvegicus"
xref: Reactome:REACT_82712 "asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate, Xenopus tropicalis"
xref: Reactome:REACT_84924 "asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate, Xenopus tropicalis"
xref: Reactome:REACT_85653 "asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate, Danio rerio"
xref: Reactome:REACT_87221 "asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate, Caenorhabditis elegans"
xref: Reactome:REACT_87884 "asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate, Drosophila melanogaster"
xref: Reactome:REACT_88735 "asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate, Gallus gallus"
xref: Reactome:REACT_90293 "asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate, Danio rerio"
xref: Reactome:REACT_90493 "asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate, Rattus norvegicus"
xref: Reactome:REACT_93184 "asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate, Canis familiaris"
xref: Reactome:REACT_93504 "asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_94698 "asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate, Oryza sativa"
xref: Reactome:REACT_97272 "asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate, Sus scrofa"
xref: Reactome:REACT_97428 "asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_97646 "asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate, Mus musculus"
xref: Reactome:REACT_98646 "asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate, Saccharomyces cerevisiae"
xref: RHEA:11183
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004817
name: cysteine-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)." [EC:6.1.1.16]
subset: gosubset_prok
synonym: "cysteine translase activity" EXACT [EC:6.1.1.16]
synonym: "cysteinyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.16]
synonym: "cysteinyl-transferRNA synthetase activity" EXACT [EC:6.1.1.16]
synonym: "cysteinyl-tRNA synthetase activity" EXACT []
synonym: "L-cysteine:tRNACys ligase (AMP-forming)" EXACT [EC:6.1.1.16]
xref: EC:6.1.1.16
xref: MetaCyc:CYSTEINE--TRNA-LIGASE-RXN
xref: Reactome:REACT_101343 "cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate, Rattus norvegicus"
xref: Reactome:REACT_101870 "cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate, Drosophila melanogaster"
xref: Reactome:REACT_102393 "cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate, Gallus gallus"
xref: Reactome:REACT_102923 "cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate, Mus musculus"
xref: Reactome:REACT_103934 "cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate, Danio rerio"
xref: Reactome:REACT_105492 "cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate, Plasmodium falciparum"
xref: Reactome:REACT_105901 "cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_106671 "cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate, Taeniopygia guttata"
xref: Reactome:REACT_109113 "cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate, Canis familiaris"
xref: Reactome:REACT_15359 "cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate, Homo sapiens"
xref: Reactome:REACT_15527 "cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate, Homo sapiens"
xref: Reactome:REACT_29700 "cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate, Xenopus tropicalis"
xref: Reactome:REACT_32946 "cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate, Rattus norvegicus"
xref: Reactome:REACT_33699 "cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate, Sus scrofa"
xref: Reactome:REACT_33890 "cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate, Xenopus tropicalis"
xref: Reactome:REACT_59684 "cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_78337 "cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_79302 "cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate, Canis familiaris"
xref: Reactome:REACT_82626 "cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate, Bos taurus"
xref: Reactome:REACT_86821 "cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_87384 "cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate, Mus musculus"
xref: Reactome:REACT_88099 "cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate, Drosophila melanogaster"
xref: Reactome:REACT_90401 "cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate, Bos taurus"
xref: Reactome:REACT_90856 "cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate, Taeniopygia guttata"
xref: Reactome:REACT_92914 "cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate, Sus scrofa"
xref: Reactome:REACT_96696 "cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate, Gallus gallus"
xref: Reactome:REACT_97727 "cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate, Caenorhabditis elegans"
xref: Reactome:REACT_98298 "cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate, Danio rerio"
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004818
name: glutamate-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)." [EC:6.1.1.17]
subset: gosubset_prok
synonym: "glutamate-tRNA synthetase activity" EXACT [EC:6.1.1.17]
synonym: "glutamic acid translase activity" EXACT [EC:6.1.1.17]
synonym: "glutamyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.17]
synonym: "glutamyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.17]
synonym: "glutamyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.17]
synonym: "glutamyl-tRNA synthetase activity" EXACT []
synonym: "L-glutamate:tRNAGlu ligase (AMP-forming) activity" EXACT [EC:6.1.1.17]
xref: EC:6.1.1.17
xref: MetaCyc:GLURS-RXN
xref: Reactome:REACT_100891 "glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate, Mus musculus"
xref: Reactome:REACT_106125 "glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate, Rattus norvegicus"
xref: Reactome:REACT_108460 "glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate, Sus scrofa"
xref: Reactome:REACT_112102 "glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate, Arabidopsis thaliana"
xref: Reactome:REACT_15345 "glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate, Homo sapiens"
xref: Reactome:REACT_15505 "glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate, Homo sapiens"
xref: Reactome:REACT_31368 "glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate, Mycobacterium tuberculosis"
xref: Reactome:REACT_31611 "glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate, Xenopus tropicalis"
xref: Reactome:REACT_32233 "glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate, Staphylococcus aureus N315"
xref: Reactome:REACT_33083 "glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate, Drosophila melanogaster"
xref: Reactome:REACT_33122 "glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate, Xenopus tropicalis"
xref: Reactome:REACT_44772 "glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_76999 "glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate, Gallus gallus"
xref: Reactome:REACT_78810 "glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate, Drosophila melanogaster"
xref: Reactome:REACT_79594 "glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_80121 "glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate, Danio rerio"
xref: Reactome:REACT_80914 "glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate, Rattus norvegicus"
xref: Reactome:REACT_82768 "glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate, Caenorhabditis elegans"
xref: Reactome:REACT_82972 "glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate, Oryza sativa"
xref: Reactome:REACT_83631 "glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate, Taeniopygia guttata"
xref: Reactome:REACT_86762 "glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate, Oryza sativa"
xref: Reactome:REACT_87201 "glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_87569 "glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate, Sus scrofa"
xref: Reactome:REACT_89939 "glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate, Taeniopygia guttata"
xref: Reactome:REACT_90335 "glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate, Plasmodium falciparum"
xref: Reactome:REACT_90784 "glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate, Canis familiaris"
xref: Reactome:REACT_93394 "glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_93957 "glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate, Arabidopsis thaliana"
xref: Reactome:REACT_95726 "glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate, Gallus gallus"
xref: Reactome:REACT_97202 "glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate, Danio rerio"
xref: Reactome:REACT_98274 "glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate, Mus musculus"
xref: Reactome:REACT_98902 "glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate, Canis familiaris"
xref: Reactome:REACT_99054 "glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate, Bos taurus"
xref: RHEA:23543
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004819
name: glutamine-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)." [EC:6.1.1.18]
subset: gosubset_prok
synonym: "GlnRS" RELATED [EC:6.1.1.18]
synonym: "glutamine translase activity" EXACT [EC:6.1.1.18]
synonym: "glutamine-tRNA synthetase activity" EXACT [EC:6.1.1.18]
synonym: "glutaminyl ribonucleic acid" RELATED [EC:6.1.1.18]
synonym: "glutaminyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.18]
synonym: "glutaminyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.18]
synonym: "glutaminyl-tRNA synthetase activity" EXACT []
synonym: "L-glutamine:tRNAGln ligase (AMP-forming)" EXACT [EC:6.1.1.18]
xref: EC:6.1.1.18
xref: MetaCyc:GLUTAMINE--TRNA-LIGASE-RXN
xref: Reactome:REACT_100055 "glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate, Rattus norvegicus"
xref: Reactome:REACT_105249 "glutamine + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_108478 "glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate, Oryza sativa"
xref: Reactome:REACT_108577 "glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate, Bos taurus"
xref: Reactome:REACT_109151 "glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate, Gallus gallus"
xref: Reactome:REACT_109271 "glutamine + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate, Drosophila melanogaster"
xref: Reactome:REACT_110337 "glutamine + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate, Sus scrofa"
xref: Reactome:REACT_114946 "glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate, Arabidopsis thaliana"
xref: Reactome:REACT_15361 "glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate, Homo sapiens"
xref: Reactome:REACT_15363 "glutamine + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate, Homo sapiens"
xref: Reactome:REACT_29079 "glutamine + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate, Plasmodium falciparum"
xref: Reactome:REACT_33993 "glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate, Sus scrofa"
xref: Reactome:REACT_77441 "glutamine + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate, Danio rerio"
xref: Reactome:REACT_78905 "glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate, Mus musculus"
xref: Reactome:REACT_79581 "glutamine + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_80721 "glutamine + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate, Arabidopsis thaliana"
xref: Reactome:REACT_81473 "glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate, Drosophila melanogaster"
xref: Reactome:REACT_81928 "glutamine + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate, Gallus gallus"
xref: Reactome:REACT_83247 "glutamine + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate, Rattus norvegicus"
xref: Reactome:REACT_84545 "glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_85071 "glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate, Xenopus tropicalis"
xref: Reactome:REACT_85193 "glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate, Danio rerio"
xref: Reactome:REACT_85262 "glutamine + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate, Bos taurus"
xref: Reactome:REACT_86255 "glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate, Canis familiaris"
xref: Reactome:REACT_89943 "glutamine + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate, Escherichia coli"
xref: Reactome:REACT_90178 "glutamine + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_90941 "glutamine + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate, Xenopus tropicalis"
xref: Reactome:REACT_91409 "glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate, Taeniopygia guttata"
xref: Reactome:REACT_91513 "glutamine + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate, Oryza sativa"
xref: Reactome:REACT_92833 "glutamine + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate, Caenorhabditis elegans"
xref: Reactome:REACT_92839 "glutamine + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate, Mus musculus"
xref: Reactome:REACT_95774 "glutamine + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate, Canis familiaris"
xref: Reactome:REACT_98223 "glutamine + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate, Taeniopygia guttata"
xref: RHEA:20124
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004820
name: glycine-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)." [EC:6.1.1.14]
subset: gosubset_prok
synonym: "glycine:tRNAGly ligase (AMP-forming) activity" EXACT [EC:6.1.1.14]
synonym: "glycyl translase activity" EXACT [EC:6.1.1.14]
synonym: "glycyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.14]
synonym: "glycyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.14]
synonym: "glycyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.14]
synonym: "glycyl-tRNA synthetase activity" EXACT []
xref: EC:6.1.1.14
xref: MetaCyc:GLYCINE--TRNA-LIGASE-RXN
xref: Reactome:REACT_100440 "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate, Taeniopygia guttata"
xref: Reactome:REACT_104151 "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate, Bos taurus"
xref: Reactome:REACT_108206 "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate, Gallus gallus"
xref: Reactome:REACT_110370 "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_15471 "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate, Homo sapiens"
xref: Reactome:REACT_15522 "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate, Homo sapiens"
xref: Reactome:REACT_28242 "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate, Rattus norvegicus"
xref: Reactome:REACT_28687 "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate, Bos taurus"
xref: Reactome:REACT_28715 "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate, Rattus norvegicus"
xref: Reactome:REACT_28828 "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate, Mus musculus"
xref: Reactome:REACT_29415 "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_29858 "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate, Drosophila melanogaster"
xref: Reactome:REACT_31382 "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate, Drosophila melanogaster"
xref: Reactome:REACT_31608 "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate, Mycobacterium tuberculosis"
xref: Reactome:REACT_32180 "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate, Plasmodium falciparum"
xref: Reactome:REACT_32579 "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate, Mus musculus"
xref: Reactome:REACT_32613 "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate, Xenopus tropicalis"
xref: Reactome:REACT_32933 "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate, Caenorhabditis elegans"
xref: Reactome:REACT_33075 "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_33634 "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_79180 "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate, Canis familiaris"
xref: Reactome:REACT_79378 "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate, Danio rerio"
xref: Reactome:REACT_79498 "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate, Plasmodium falciparum"
xref: Reactome:REACT_80661 "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate, Staphylococcus aureus N315"
xref: Reactome:REACT_81915 "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate, Gallus gallus"
xref: Reactome:REACT_82194 "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate, Oryza sativa"
xref: Reactome:REACT_83948 "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate, Caenorhabditis elegans"
xref: Reactome:REACT_85878 "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate, Danio rerio"
xref: Reactome:REACT_86692 "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate, Sus scrofa"
xref: Reactome:REACT_89308 "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate, Arabidopsis thaliana"
xref: Reactome:REACT_90172 "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate, Canis familiaris"
xref: Reactome:REACT_90194 "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate, Mycobacterium tuberculosis"
xref: Reactome:REACT_90304 "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_91291 "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate, Sus scrofa"
xref: Reactome:REACT_94097 "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate, Staphylococcus aureus N315"
xref: Reactome:REACT_94270 "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate, Oryza sativa"
xref: Reactome:REACT_95464 "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate, Xenopus tropicalis"
xref: Reactome:REACT_97190 "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_98380 "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate, Taeniopygia guttata"
xref: Reactome:REACT_99496 "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate, Arabidopsis thaliana"
xref: RHEA:16016
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004821
name: histidine-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His)." [EC:6.1.1.21]
subset: gosubset_prok
synonym: "histidine translase activity" EXACT [EC:6.1.1.21]
synonym: "histidyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.21]
synonym: "histidyl-tRNA synthetase activity" EXACT []
synonym: "L-histidine:tRNAHis ligase (AMP-forming)" EXACT [EC:6.1.1.21]
xref: EC:6.1.1.21
xref: MetaCyc:HISTIDINE--TRNA-LIGASE-RXN
xref: Reactome:REACT_104519 "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate, Bos taurus"
xref: Reactome:REACT_105200 "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate, Danio rerio"
xref: Reactome:REACT_107204 "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate, Xenopus tropicalis"
xref: Reactome:REACT_107326 "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate, Sus scrofa"
xref: Reactome:REACT_107762 "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate, Mus musculus"
xref: Reactome:REACT_107887 "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate, Oryza sativa"
xref: Reactome:REACT_109688 "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate, Xenopus tropicalis"
xref: Reactome:REACT_15315 "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate, Homo sapiens"
xref: Reactome:REACT_15376 "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate, Homo sapiens"
xref: Reactome:REACT_28353 "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate, Rattus norvegicus"
xref: Reactome:REACT_29231 "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_29244 "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate, Oryza sativa"
xref: Reactome:REACT_30681 "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate, Bos taurus"
xref: Reactome:REACT_31889 "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate, Plasmodium falciparum"
xref: Reactome:REACT_33372 "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate, Sus scrofa"
xref: Reactome:REACT_55250 "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate, Mus musculus"
xref: Reactome:REACT_77935 "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_78077 "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_78521 "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate, Gallus gallus"
xref: Reactome:REACT_78842 "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate, Drosophila melanogaster"
xref: Reactome:REACT_79146 "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate, Danio rerio"
xref: Reactome:REACT_82117 "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate, Gallus gallus"
xref: Reactome:REACT_85438 "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate, Canis familiaris"
xref: Reactome:REACT_86140 "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate, Taeniopygia guttata"
xref: Reactome:REACT_86389 "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_86522 "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate, Canis familiaris"
xref: Reactome:REACT_89500 "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate, Caenorhabditis elegans"
xref: Reactome:REACT_92036 "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_93518 "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate, Taeniopygia guttata"
xref: Reactome:REACT_93945 "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate, Rattus norvegicus"
xref: Reactome:REACT_94191 "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate, Arabidopsis thaliana"
xref: Reactome:REACT_94634 "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate, Drosophila melanogaster"
xref: Reactome:REACT_97713 "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate, Caenorhabditis elegans"
xref: Reactome:REACT_98128 "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate, Plasmodium falciparum"
xref: Reactome:REACT_98152 "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_99588 "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate, Arabidopsis thaliana"
xref: RHEA:17316
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004822
name: isoleucine-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H(+)." [EC:6.1.1.5, RHEA:11063]
subset: gosubset_prok
synonym: "isoleucine translase activity" EXACT [EC:6.1.1.5]
synonym: "isoleucine-transfer RNA ligase activity" EXACT [EC:6.1.1.5]
synonym: "isoleucine-tRNA synthetase activity" EXACT [EC:6.1.1.5]
synonym: "isoleucyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.5]
synonym: "isoleucyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.5]
synonym: "isoleucyl-tRNA synthetase activity" EXACT []
synonym: "L-isoleucine:tRNAIle ligase (AMP-forming)" EXACT [EC:6.1.1.5]
xref: EC:6.1.1.5
xref: KEGG:R03656
xref: MetaCyc:ISOLEUCINE--TRNA-LIGASE-RXN
xref: Reactome:REACT_102981 "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_103282 "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_103697 "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate, Sus scrofa"
xref: Reactome:REACT_104897 "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate, Xenopus tropicalis"
xref: Reactome:REACT_105921 "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate, Taeniopygia guttata"
xref: Reactome:REACT_109320 "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate, Xenopus tropicalis"
xref: Reactome:REACT_109709 "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate, Bos taurus"
xref: Reactome:REACT_112356 "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate, Plasmodium falciparum"
xref: Reactome:REACT_112543 "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate, Arabidopsis thaliana"
xref: Reactome:REACT_15423 "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate, Homo sapiens"
xref: Reactome:REACT_15516 "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate, Homo sapiens"
xref: Reactome:REACT_28455 "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate, Mus musculus"
xref: Reactome:REACT_30418 "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate, Caenorhabditis elegans"
xref: Reactome:REACT_31113 "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate, Gallus gallus"
xref: Reactome:REACT_34131 "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate, Rattus norvegicus"
xref: Reactome:REACT_78448 "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate, Sus scrofa"
xref: Reactome:REACT_79408 "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_81208 "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate, Gallus gallus"
xref: Reactome:REACT_84116 "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate, Danio rerio"
xref: Reactome:REACT_84178 "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_85041 "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate, Canis familiaris"
xref: Reactome:REACT_85530 "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate, Drosophila melanogaster"
xref: Reactome:REACT_87224 "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate, Canis familiaris"
xref: Reactome:REACT_88047 "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate, Staphylococcus aureus N315"
xref: Reactome:REACT_88866 "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate, Escherichia coli"
xref: Reactome:REACT_88889 "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate, Drosophila melanogaster"
xref: Reactome:REACT_88999 "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate, Mus musculus"
xref: Reactome:REACT_89281 "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate, Oryza sativa"
xref: Reactome:REACT_93338 "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate, Oryza sativa"
xref: Reactome:REACT_94499 "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate, Taeniopygia guttata"
xref: Reactome:REACT_96667 "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate, Rattus norvegicus"
xref: Reactome:REACT_96848 "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate, Bos taurus"
xref: Reactome:REACT_97057 "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate, Arabidopsis thaliana"
xref: Reactome:REACT_99836 "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate, Danio rerio"
xref: RHEA:11063
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004823
name: leucine-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H(+) + Leu-tRNA(Leu)." [EC:6.1.1.4, RHEA:11691]
subset: gosubset_prok
synonym: "L-leucine:tRNALeu ligase (AMP-forming)" EXACT [EC:6.1.1.4]
synonym: "leucine translase activity" EXACT [EC:6.1.1.4]
synonym: "leucine-tRNA synthetase activity" EXACT [EC:6.1.1.4]
synonym: "leucyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.4]
synonym: "leucyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.4]
synonym: "leucyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.4]
synonym: "leucyl-tRNA synthetase activity" EXACT []
xref: EC:6.1.1.4
xref: KEGG:R03657
xref: MetaCyc:LEUCINE--TRNA-LIGASE-RXN
xref: Reactome:REACT_100022 "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate, Canis familiaris"
xref: Reactome:REACT_106387 "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate, Escherichia coli"
xref: Reactome:REACT_107697 "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate, Bos taurus"
xref: Reactome:REACT_108072 "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate, Oryza sativa"
xref: Reactome:REACT_109199 "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_110915 "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate, Xenopus tropicalis"
xref: Reactome:REACT_113044 "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate, Arabidopsis thaliana"
xref: Reactome:REACT_15357 "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate, Homo sapiens"
xref: Reactome:REACT_15504 "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate, Homo sapiens"
xref: Reactome:REACT_28095 "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate, Rattus norvegicus"
xref: Reactome:REACT_29175 "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate, Danio rerio"
xref: Reactome:REACT_29944 "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate, Sus scrofa"
xref: Reactome:REACT_30114 "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate, Bos taurus"
xref: Reactome:REACT_30248 "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate, Gallus gallus"
xref: Reactome:REACT_30669 "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate, Plasmodium falciparum"
xref: Reactome:REACT_31192 "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate, Xenopus tropicalis"
xref: Reactome:REACT_31653 "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_33620 "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate, Mycobacterium tuberculosis"
xref: Reactome:REACT_34333 "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate, Rattus norvegicus"
xref: Reactome:REACT_77035 "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_77387 "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate, Drosophila melanogaster"
xref: Reactome:REACT_77701 "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate, Taeniopygia guttata"
xref: Reactome:REACT_77860 "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate, Mus musculus"
xref: Reactome:REACT_80692 "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate, Arabidopsis thaliana"
xref: Reactome:REACT_81044 "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate, Sus scrofa"
xref: Reactome:REACT_87398 "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate, Gallus gallus"
xref: Reactome:REACT_87517 "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate, Oryza sativa"
xref: Reactome:REACT_87858 "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate, Staphylococcus aureus N315"
xref: Reactome:REACT_88675 "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate, Taeniopygia guttata"
xref: Reactome:REACT_89901 "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate, Canis familiaris"
xref: Reactome:REACT_94501 "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_94533 "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate, Mus musculus"
xref: Reactome:REACT_95445 "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate, Danio rerio"
xref: Reactome:REACT_98538 "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate, Caenorhabditis elegans"
xref: Reactome:REACT_99756 "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate, Drosophila melanogaster"
xref: RHEA:11691
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004824
name: lysine-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)." [EC:6.1.1.6]
subset: gosubset_prok
synonym: "L-lysine-transfer RNA ligase activity" EXACT [EC:6.1.1.6]
synonym: "L-lysine:tRNALys ligase (AMP-forming)" EXACT [EC:6.1.1.6]
synonym: "lysine translase activity" EXACT [EC:6.1.1.6]
synonym: "lysine-tRNA synthetase activity" EXACT [EC:6.1.1.6]
synonym: "lysyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.6]
synonym: "lysyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.6]
synonym: "lysyl-tRNA synthetase activity" EXACT []
xref: EC:6.1.1.6
xref: MetaCyc:LYSINE--TRNA-LIGASE-RXN
xref: Reactome:REACT_100665 "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate, Bos taurus"
xref: Reactome:REACT_100778 "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate, Plasmodium falciparum"
xref: Reactome:REACT_101252 "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate, Taeniopygia guttata"
xref: Reactome:REACT_101558 "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate, Sus scrofa"
xref: Reactome:REACT_103719 "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate, Danio rerio"
xref: Reactome:REACT_105147 "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate, Canis familiaris"
xref: Reactome:REACT_106179 "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate, Mycobacterium tuberculosis"
xref: Reactome:REACT_106608 "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_110609 "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate, Drosophila melanogaster"
xref: Reactome:REACT_112280 "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate, Staphylococcus aureus N315"
xref: Reactome:REACT_112322 "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate, Arabidopsis thaliana"
xref: Reactome:REACT_113853 "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate, Arabidopsis thaliana"
xref: Reactome:REACT_15342 "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate, Homo sapiens"
xref: Reactome:REACT_15537 "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate, Homo sapiens"
xref: Reactome:REACT_28617 "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_28928 "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate, Sus scrofa"
xref: Reactome:REACT_77296 "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate, Caenorhabditis elegans"
xref: Reactome:REACT_77302 "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate, Rattus norvegicus"
xref: Reactome:REACT_77330 "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate, Xenopus tropicalis"
xref: Reactome:REACT_80440 "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_83902 "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate, Oryza sativa"
xref: Reactome:REACT_85818 "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate, Gallus gallus"
xref: Reactome:REACT_86287 "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate, Rattus norvegicus"
xref: Reactome:REACT_86941 "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate, Xenopus tropicalis"
xref: Reactome:REACT_88710 "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate, Gallus gallus"
xref: Reactome:REACT_89412 "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate, Taeniopygia guttata"
xref: Reactome:REACT_90775 "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate, Danio rerio"
xref: Reactome:REACT_91357 "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate, Drosophila melanogaster"
xref: Reactome:REACT_94275 "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate, Mus musculus"
xref: Reactome:REACT_94658 "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate, Bos taurus"
xref: Reactome:REACT_94914 "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate, Canis familiaris"
xref: Reactome:REACT_95223 "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_95346 "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate, Mus musculus"
xref: Reactome:REACT_97008 "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate, Oryza sativa"
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004825
name: methionine-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)." [EC:6.1.1.10]
subset: gosubset_prok
synonym: "L-methionine:tRNAMet ligase (AMP-forming)" EXACT [EC:6.1.1.10]
synonym: "methionine translase activity" EXACT [EC:6.1.1.10]
synonym: "methionyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.10]
synonym: "methionyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.10]
synonym: "methionyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.10]
synonym: "methionyl-tRNA synthetase activity" EXACT []
synonym: "MetRS activity" EXACT [EC:6.1.1.10]
xref: EC:6.1.1.10
xref: MetaCyc:METHIONINE--TRNA-LIGASE-RXN
xref: Reactome:REACT_109528 "methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate, Drosophila melanogaster"
xref: Reactome:REACT_110904 "methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate, Canis familiaris"
xref: Reactome:REACT_112098 "methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_112796 "methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate, Sus scrofa"
xref: Reactome:REACT_112814 "methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate, Oryza sativa"
xref: Reactome:REACT_112913 "methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate, Rattus norvegicus"
xref: Reactome:REACT_112985 "methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_113327 "methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_113473 "methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate, Bos taurus"
xref: Reactome:REACT_113488 "methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate, Taeniopygia guttata"
xref: Reactome:REACT_113546 "methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate, Arabidopsis thaliana"
xref: Reactome:REACT_113638 "methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate, Plasmodium falciparum"
xref: Reactome:REACT_113646 "methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate, Danio rerio"
xref: Reactome:REACT_113871 "methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate, Arabidopsis thaliana"
xref: Reactome:REACT_114216 "methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate, Mus musculus"
xref: Reactome:REACT_114281 "methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate, Canis familiaris"
xref: Reactome:REACT_114409 "methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate, Gallus gallus"
xref: Reactome:REACT_114525 "methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate, Drosophila melanogaster"
xref: Reactome:REACT_114728 "methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate, Staphylococcus aureus N315"
xref: Reactome:REACT_114871 "methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate, Xenopus tropicalis"
xref: Reactome:REACT_114923 "methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate, Mycobacterium tuberculosis"
xref: Reactome:REACT_115107 "methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate, Caenorhabditis elegans"
xref: Reactome:REACT_115242 "methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate, Escherichia coli"
xref: Reactome:REACT_15420 "methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate, Homo sapiens"
xref: Reactome:REACT_15446 "methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate, Homo sapiens"
xref: Reactome:REACT_34053 "methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate, Rattus norvegicus"
xref: Reactome:REACT_34217 "methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate, Sus scrofa"
xref: Reactome:REACT_78928 "methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_80592 "methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate, Bos taurus"
xref: Reactome:REACT_81380 "methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate, Danio rerio"
xref: Reactome:REACT_82802 "methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate, Mus musculus"
xref: Reactome:REACT_82836 "methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate, Oryza sativa"
xref: Reactome:REACT_83559 "methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate, Gallus gallus"
xref: Reactome:REACT_87518 "methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate, Xenopus tropicalis"
xref: Reactome:REACT_97872 "methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate, Taeniopygia guttata"
xref: RHEA:13484
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004826
name: phenylalanine-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)." [EC:6.1.1.20]
subset: gosubset_prok
synonym: "L-phenylalanine:tRNAPhe ligase (AMP-forming) activity" EXACT [EC:6.1.1.20]
synonym: "L-phenylalanyl-tRNA synthetase activity" EXACT [EC:6.1.1.20]
synonym: "phenylalanine translase activity" EXACT [EC:6.1.1.20]
synonym: "phenylalanine-tRNA synthetase activity" EXACT [EC:6.1.1.20]
synonym: "phenylalanyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.20]
synonym: "phenylalanyl-transfer RNA ligase activity" EXACT [EC:6.1.1.20]
synonym: "phenylalanyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.20]
synonym: "phenylalanyl-tRNA ligase activity" EXACT [EC:6.1.1.20]
synonym: "phenylalanyl-tRNA synthetase activity" EXACT []
xref: EC:6.1.1.20
xref: MetaCyc:PHENYLALANINE--TRNA-LIGASE-RXN
xref: Reactome:REACT_100836 "phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate, Arabidopsis thaliana"
xref: Reactome:REACT_101294 "phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate, Rattus norvegicus"
xref: Reactome:REACT_103801 "phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate, Canis familiaris"
xref: Reactome:REACT_106607 "phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate, Oryza sativa"
xref: Reactome:REACT_107437 "phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_108723 "phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate, Sus scrofa"
xref: Reactome:REACT_109048 "phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate, Plasmodium falciparum"
xref: Reactome:REACT_110961 "phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate, Taeniopygia guttata"
xref: Reactome:REACT_112009 "phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate, Oryza sativa"
xref: Reactome:REACT_112342 "phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate, Gallus gallus"
xref: Reactome:REACT_112442 "phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_112609 "phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate, Arabidopsis thaliana"
xref: Reactome:REACT_113739 "phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate, Drosophila melanogaster"
xref: Reactome:REACT_114559 "phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate, Caenorhabditis elegans"
xref: Reactome:REACT_114632 "phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate, Plasmodium falciparum"
xref: Reactome:REACT_114633 "phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_114689 "phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_115103 "phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate, Xenopus tropicalis"
xref: Reactome:REACT_15328 "phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate, Homo sapiens"
xref: Reactome:REACT_15462 "phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate, Homo sapiens"
xref: Reactome:REACT_33690 "phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate, Canis familiaris"
xref: Reactome:REACT_77960 "phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate, Caenorhabditis elegans"
xref: Reactome:REACT_81017 "phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate, Xenopus tropicalis"
xref: Reactome:REACT_83203 "phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate, Bos taurus"
xref: Reactome:REACT_83562 "phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate, Danio rerio"
xref: Reactome:REACT_83622 "phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate, Mus musculus"
xref: Reactome:REACT_87145 "phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate, Danio rerio"
xref: Reactome:REACT_87720 "phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate, Sus scrofa"
xref: Reactome:REACT_90251 "phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_94155 "phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate, Rattus norvegicus"
xref: Reactome:REACT_94735 "phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate, Taeniopygia guttata"
xref: Reactome:REACT_95079 "phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate, Drosophila melanogaster"
xref: Reactome:REACT_97925 "phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate, Mus musculus"
xref: Reactome:REACT_98200 "phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate, Bos taurus"
xref: Reactome:REACT_98851 "phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate, Saccharomyces cerevisiae"
xref: RHEA:19416
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004827
name: proline-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)." [EC:6.1.1.15]
subset: gosubset_prok
synonym: "L-proline:tRNAPro ligase (AMP-forming)" EXACT [EC:6.1.1.15]
synonym: "proline translase activity" EXACT [EC:6.1.1.15]
synonym: "prolinyl-tRNA ligase activity" EXACT [EC:6.1.1.15]
synonym: "prolyl-s-RNA synthetase activity" EXACT [EC:6.1.1.15]
synonym: "prolyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.15]
synonym: "prolyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.15]
synonym: "prolyl-transferRNA synthetase activity" EXACT [EC:6.1.1.15]
synonym: "prolyl-tRNA synthetase activity" EXACT []
xref: EC:6.1.1.15
xref: MetaCyc:PROLINE--TRNA-LIGASE-RXN
xref: Reactome:REACT_100367 "proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate, Bos taurus"
xref: Reactome:REACT_105710 "proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate, Mus musculus"
xref: Reactome:REACT_105783 "proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate, Rattus norvegicus"
xref: Reactome:REACT_107419 "proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate, Mus musculus"
xref: Reactome:REACT_108253 "proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate, Caenorhabditis elegans"
xref: Reactome:REACT_108727 "proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate, Xenopus tropicalis"
xref: Reactome:REACT_109574 "proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate, Sus scrofa"
xref: Reactome:REACT_110447 "proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_113180 "proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate, Arabidopsis thaliana"
xref: Reactome:REACT_15310 "proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate, Homo sapiens"
xref: Reactome:REACT_15436 "proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate, Homo sapiens"
xref: Reactome:REACT_30229 "proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate, Canis familiaris"
xref: Reactome:REACT_32085 "proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate, Drosophila melanogaster"
xref: Reactome:REACT_32356 "proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate, Escherichia coli"
xref: Reactome:REACT_33109 "proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate, Drosophila melanogaster"
xref: Reactome:REACT_33638 "proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate, Bos taurus"
xref: Reactome:REACT_34251 "proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_34371 "proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate, Rattus norvegicus"
xref: Reactome:REACT_79889 "proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate, Danio rerio"
xref: Reactome:REACT_80321 "proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate, Taeniopygia guttata"
xref: Reactome:REACT_81384 "proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate, Gallus gallus"
xref: Reactome:REACT_81988 "proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate, Oryza sativa"
xref: Reactome:REACT_83595 "proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate, Staphylococcus aureus N315"
xref: Reactome:REACT_86793 "proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate, Sus scrofa"
xref: Reactome:REACT_88356 "proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_88399 "proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate, Gallus gallus"
xref: Reactome:REACT_88688 "proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_90052 "proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate, Canis familiaris"
xref: Reactome:REACT_92617 "proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate, Plasmodium falciparum"
xref: Reactome:REACT_97355 "proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate, Danio rerio"
xref: Reactome:REACT_98740 "proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate, Mycobacterium tuberculosis"
xref: Reactome:REACT_99897 "proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate, Taeniopygia guttata"
xref: RHEA:14308
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004828
name: serine-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser)." [EC:6.1.1.11]
subset: gosubset_prok
synonym: "L-serine:tRNASer ligase (AMP-forming)" EXACT [EC:6.1.1.11]
synonym: "serine translase activity" EXACT [EC:6.1.1.11]
synonym: "SerRS activity" EXACT [EC:6.1.1.11]
synonym: "seryl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.11]
synonym: "seryl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.11]
synonym: "seryl-transfer RNA synthetase activity" EXACT [EC:6.1.1.11]
synonym: "seryl-tRNA synthetase activity" EXACT []
xref: EC:6.1.1.11
xref: MetaCyc:SERINE--TRNA-LIGASE-RXN
xref: Reactome:REACT_100123 "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate, Drosophila melanogaster"
xref: Reactome:REACT_101186 "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate, Sus scrofa"
xref: Reactome:REACT_101371 "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate, Sus scrofa"
xref: Reactome:REACT_102890 "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate, Oryza sativa"
xref: Reactome:REACT_103427 "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_103712 "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate, Rattus norvegicus"
xref: Reactome:REACT_105286 "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate, Bos taurus"
xref: Reactome:REACT_105864 "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate, Xenopus tropicalis"
xref: Reactome:REACT_108011 "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate, Canis familiaris"
xref: Reactome:REACT_112205 "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate, Staphylococcus aureus N315"
xref: Reactome:REACT_113323 "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate, Mycobacterium tuberculosis"
xref: Reactome:REACT_114211 "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate, Plasmodium falciparum"
xref: Reactome:REACT_115009 "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate, Escherichia coli"
xref: Reactome:REACT_15400 "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate, Homo sapiens"
xref: Reactome:REACT_15501 "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate, Homo sapiens"
xref: Reactome:REACT_28399 "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate, Xenopus tropicalis"
xref: Reactome:REACT_30324 "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate, Bos taurus"
xref: Reactome:REACT_31127 "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate, Plasmodium falciparum"
xref: Reactome:REACT_34489 "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate, Oryza sativa"
xref: Reactome:REACT_53856 "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate, Caenorhabditis elegans"
xref: Reactome:REACT_78449 "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate, Mus musculus"
xref: Reactome:REACT_80479 "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_80675 "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate, Arabidopsis thaliana"
xref: Reactome:REACT_81542 "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate, Mus musculus"
xref: Reactome:REACT_81954 "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate, Danio rerio"
xref: Reactome:REACT_83837 "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate, Rattus norvegicus"
xref: Reactome:REACT_86581 "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_89335 "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate, Drosophila melanogaster"
xref: Reactome:REACT_91976 "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_93512 "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate, Canis familiaris"
xref: Reactome:REACT_94466 "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate, Danio rerio"
xref: Reactome:REACT_94515 "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate, Caenorhabditis elegans"
xref: Reactome:REACT_95075 "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_97797 "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_98107 "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate, Arabidopsis thaliana"
xref: Reactome:REACT_98742 "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate, Gallus gallus"
xref: Reactome:REACT_99863 "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate, Taeniopygia guttata"
xref: RHEA:12295
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004829
name: threonine-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr)." [EC:6.1.1.3]
subset: gosubset_prok
synonym: "L-threonine:tRNAThr ligase (AMP-forming)" EXACT [EC:6.1.1.3]
synonym: "threonine translase activity" EXACT [EC:6.1.1.3]
synonym: "threonine-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.3]
synonym: "threonyl ribonucleic synthetase activity" EXACT [EC:6.1.1.3]
synonym: "threonyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.3]
synonym: "threonyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.3]
synonym: "threonyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.3]
synonym: "threonyl-tRNA synthetase activity" EXACT []
synonym: "TRS" RELATED [EC:6.1.1.3]
xref: EC:6.1.1.3
xref: MetaCyc:THREONINE--TRNA-LIGASE-RXN
xref: Reactome:REACT_104665 "threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate, Danio rerio"
xref: Reactome:REACT_105132 "threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate, Canis familiaris"
xref: Reactome:REACT_106091 "threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate, Taeniopygia guttata"
xref: Reactome:REACT_106246 "threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate, Sus scrofa"
xref: Reactome:REACT_112924 "threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate, Xenopus tropicalis"
xref: Reactome:REACT_15330 "threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate, Homo sapiens"
xref: Reactome:REACT_15487 "threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate, Homo sapiens"
xref: Reactome:REACT_31688 "threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate, Taeniopygia guttata"
xref: Reactome:REACT_80127 "threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate, Rattus norvegicus"
xref: Reactome:REACT_82096 "threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate, Gallus gallus"
xref: Reactome:REACT_82287 "threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate, Xenopus tropicalis"
xref: Reactome:REACT_83183 "threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate, Bos taurus"
xref: Reactome:REACT_83779 "threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate, Mus musculus"
xref: Reactome:REACT_89709 "threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate, Canis familiaris"
xref: Reactome:REACT_90184 "threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate, Danio rerio"
xref: Reactome:REACT_92082 "threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate, Rattus norvegicus"
xref: Reactome:REACT_94586 "threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate, Mus musculus"
xref: Reactome:REACT_99813 "threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate, Bos taurus"
xref: RHEA:24627
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004830
name: tryptophan-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp)." [EC:6.1.1.2]
subset: gosubset_prok
synonym: "L-tryptophan-tRNA(Trp) ligase (AMP-forming) activity" EXACT [EC:6.1.1.2]
synonym: "L-tryptophan-tRNATrp ligase (AMP-forming)" EXACT [EC:6.1.1.2]
synonym: "L-tryptophan:tRNATrp ligase (AMP-forming)" EXACT [EC:6.1.1.2]
synonym: "TrpRS activity" EXACT [EC:6.1.1.2]
synonym: "tryptophan translase activity" EXACT [EC:6.1.1.2]
synonym: "tryptophanyl ribonucleic synthetase activity" EXACT [EC:6.1.1.2]
synonym: "tryptophanyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.2]
synonym: "tryptophanyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.2]
synonym: "tryptophanyl-transfer ribonucleic synthetase activity" EXACT [EC:6.1.1.2]
synonym: "tryptophanyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.2]
synonym: "tryptophanyl-tRNA synthase activity" EXACT [EC:6.1.1.2]
synonym: "tryptophanyl-tRNA synthetase activity" EXACT []
xref: EC:6.1.1.2
xref: MetaCyc:TRYPTOPHAN--TRNA-LIGASE-RXN
xref: Reactome:REACT_100097 "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate, Danio rerio"
xref: Reactome:REACT_100218 "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate, Rattus norvegicus"
xref: Reactome:REACT_100666 "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate, Arabidopsis thaliana"
xref: Reactome:REACT_101894 "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate, Mus musculus"
xref: Reactome:REACT_102287 "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate, Bos taurus"
xref: Reactome:REACT_102814 "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate, Bos taurus"
xref: Reactome:REACT_102901 "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate, Taeniopygia guttata"
xref: Reactome:REACT_104142 "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_105601 "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate, Gallus gallus"
xref: Reactome:REACT_105704 "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate, Rattus norvegicus"
xref: Reactome:REACT_108647 "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate, Arabidopsis thaliana"
xref: Reactome:REACT_109481 "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_110778 "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate, Drosophila melanogaster"
xref: Reactome:REACT_15343 "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate, Homo sapiens"
xref: Reactome:REACT_15412 "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate, Homo sapiens"
xref: Reactome:REACT_30118 "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate, Mus musculus"
xref: Reactome:REACT_33782 "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate, Sus scrofa"
xref: Reactome:REACT_34108 "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate, Drosophila melanogaster"
xref: Reactome:REACT_34156 "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate, Escherichia coli"
xref: Reactome:REACT_34791 "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate, Oryza sativa"
xref: Reactome:REACT_77584 "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate, Oryza sativa"
xref: Reactome:REACT_77807 "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_79173 "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate, Plasmodium falciparum"
xref: Reactome:REACT_80254 "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate, Mycobacterium tuberculosis"
xref: Reactome:REACT_80769 "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate, Staphylococcus aureus N315"
xref: Reactome:REACT_82231 "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate, Canis familiaris"
xref: Reactome:REACT_82362 "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate, Xenopus tropicalis"
xref: Reactome:REACT_82400 "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_82642 "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate, Taeniopygia guttata"
xref: Reactome:REACT_85185 "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate, Canis familiaris"
xref: Reactome:REACT_85284 "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_88098 "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_91521 "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate, Caenorhabditis elegans"
xref: Reactome:REACT_92147 "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate, Caenorhabditis elegans"
xref: Reactome:REACT_96722 "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate, Danio rerio"
xref: Reactome:REACT_96974 "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate, Plasmodium falciparum"
xref: Reactome:REACT_97599 "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate, Sus scrofa"
xref: Reactome:REACT_99349 "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate, Gallus gallus"
xref: RHEA:24083
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004831
name: tyrosine-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H(+)." [EC:6.1.1.1, RHEA:10223]
subset: gosubset_prok
synonym: "L-tyrosine-tRNA(Tyr) ligase (AMP-forming) activity" EXACT [EC:6.1.1.1]
synonym: "L-tyrosine-tRNATyr ligase (AMP-forming)" EXACT [EC:6.1.1.1]
synonym: "L-tyrosine:tRNATyr ligase (AMP-forming)" EXACT [EC:6.1.1.1]
synonym: "tyrosine translase activity" EXACT [EC:6.1.1.1]
synonym: "tyrosine tRNA synthetase activity" EXACT [EC:6.1.1.1]
synonym: "tyrosine-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.1]
synonym: "tyrosine-transfer RNA ligase activity" EXACT [EC:6.1.1.1]
synonym: "tyrosyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.1]
synonym: "tyrosyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.1]
synonym: "tyrosyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.1]
synonym: "tyrosyl-tRNA ligase activity" EXACT [EC:6.1.1.1]
synonym: "tyrosyl-tRNA synthetase activity" EXACT []
xref: EC:6.1.1.1
xref: KEGG:R02918
xref: MetaCyc:TYROSINE--TRNA-LIGASE-RXN
xref: Reactome:REACT_100043 "tyrosine + tRNA(Tyr) + ATP => Tyr-tRNA(Tyr) + AMP + pyrophosphate, Xenopus tropicalis"
xref: Reactome:REACT_100137 "tyrosine + tRNA(Tyr) + ATP => Tyr-tRNA(Tyr) + AMP + pyrophosphate, Danio rerio"
xref: Reactome:REACT_101460 "tyrosine + tRNA(Tyr) + ATP => Tyr-tRNA(Tyr) + AMP + pyrophosphate, Caenorhabditis elegans"
xref: Reactome:REACT_102539 "tyrosine + tRNA(Tyr) + ATP =>Tyr-tRNA(Tyr) + AMP + pyrophosphate, Canis familiaris"
xref: Reactome:REACT_103102 "tyrosine + tRNA(Tyr) + ATP =>Tyr-tRNA(Tyr) + AMP + pyrophosphate, Mus musculus"
xref: Reactome:REACT_103463 "tyrosine + tRNA(Tyr) + ATP =>Tyr-tRNA(Tyr) + AMP + pyrophosphate, Bos taurus"
xref: Reactome:REACT_104741 "tyrosine + tRNA(Tyr) + ATP => Tyr-tRNA(Tyr) + AMP + pyrophosphate, Bos taurus"
xref: Reactome:REACT_105268 "tyrosine + tRNA(Tyr) + ATP => Tyr-tRNA(Tyr) + AMP + pyrophosphate, Escherichia coli"
xref: Reactome:REACT_113020 "tyrosine + tRNA(Tyr) + ATP =>Tyr-tRNA(Tyr) + AMP + pyrophosphate, Drosophila melanogaster"
xref: Reactome:REACT_113391 "tyrosine + tRNA(Tyr) + ATP =>Tyr-tRNA(Tyr) + AMP + pyrophosphate, Escherichia coli"
xref: Reactome:REACT_15351 "tyrosine + tRNA(Tyr) + ATP => Tyr-tRNA(Tyr) + AMP + pyrophosphate, Homo sapiens"
xref: Reactome:REACT_15492 "tyrosine + tRNA(Tyr) + ATP =>Tyr-tRNA(Tyr) + AMP + pyrophosphate, Homo sapiens"
xref: Reactome:REACT_28241 "tyrosine + tRNA(Tyr) + ATP =>Tyr-tRNA(Tyr) + AMP + pyrophosphate, Rattus norvegicus"
xref: Reactome:REACT_28530 "tyrosine + tRNA(Tyr) + ATP => Tyr-tRNA(Tyr) + AMP + pyrophosphate, Rattus norvegicus"
xref: Reactome:REACT_34543 "tyrosine + tRNA(Tyr) + ATP => Tyr-tRNA(Tyr) + AMP + pyrophosphate, Gallus gallus"
xref: Reactome:REACT_34569 "tyrosine + tRNA(Tyr) + ATP => Tyr-tRNA(Tyr) + AMP + pyrophosphate, Mus musculus"
xref: Reactome:REACT_34764 "tyrosine + tRNA(Tyr) + ATP => Tyr-tRNA(Tyr) + AMP + pyrophosphate, Taeniopygia guttata"
xref: Reactome:REACT_48215 "tyrosine + tRNA(Tyr) + ATP => Tyr-tRNA(Tyr) + AMP + pyrophosphate, Plasmodium falciparum"
xref: Reactome:REACT_77160 "tyrosine + tRNA(Tyr) + ATP => Tyr-tRNA(Tyr) + AMP + pyrophosphate, Canis familiaris"
xref: Reactome:REACT_77273 "tyrosine + tRNA(Tyr) + ATP =>Tyr-tRNA(Tyr) + AMP + pyrophosphate, Plasmodium falciparum"
xref: Reactome:REACT_83802 "tyrosine + tRNA(Tyr) + ATP =>Tyr-tRNA(Tyr) + AMP + pyrophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_84820 "tyrosine + tRNA(Tyr) + ATP => Tyr-tRNA(Tyr) + AMP + pyrophosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_85415 "tyrosine + tRNA(Tyr) + ATP =>Tyr-tRNA(Tyr) + AMP + pyrophosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_85930 "tyrosine + tRNA(Tyr) + ATP =>Tyr-tRNA(Tyr) + AMP + pyrophosphate, Xenopus tropicalis"
xref: Reactome:REACT_88185 "tyrosine + tRNA(Tyr) + ATP => Tyr-tRNA(Tyr) + AMP + pyrophosphate, Mycobacterium tuberculosis"
xref: Reactome:REACT_90300 "tyrosine + tRNA(Tyr) + ATP =>Tyr-tRNA(Tyr) + AMP + pyrophosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_91257 "tyrosine + tRNA(Tyr) + ATP =>Tyr-tRNA(Tyr) + AMP + pyrophosphate, Danio rerio"
xref: Reactome:REACT_92035 "tyrosine + tRNA(Tyr) + ATP => Tyr-tRNA(Tyr) + AMP + pyrophosphate, Drosophila melanogaster"
xref: Reactome:REACT_92056 "tyrosine + tRNA(Tyr) + ATP => Tyr-tRNA(Tyr) + AMP + pyrophosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_92554 "tyrosine + tRNA(Tyr) + ATP => Tyr-tRNA(Tyr) + AMP + pyrophosphate, Oryza sativa"
xref: Reactome:REACT_92768 "tyrosine + tRNA(Tyr) + ATP =>Tyr-tRNA(Tyr) + AMP + pyrophosphate, Taeniopygia guttata"
xref: Reactome:REACT_94007 "tyrosine + tRNA(Tyr) + ATP => Tyr-tRNA(Tyr) + AMP + pyrophosphate, Arabidopsis thaliana"
xref: Reactome:REACT_95503 "tyrosine + tRNA(Tyr) + ATP =>Tyr-tRNA(Tyr) + AMP + pyrophosphate, Gallus gallus"
xref: Reactome:REACT_96791 "tyrosine + tRNA(Tyr) + ATP =>Tyr-tRNA(Tyr) + AMP + pyrophosphate, Arabidopsis thaliana"
xref: Reactome:REACT_97182 "tyrosine + tRNA(Tyr) + ATP =>Tyr-tRNA(Tyr) + AMP + pyrophosphate, Oryza sativa"
xref: Reactome:REACT_97822 "tyrosine + tRNA(Tyr) + ATP => Tyr-tRNA(Tyr) + AMP + pyrophosphate, Staphylococcus aureus N315"
xref: Reactome:REACT_97940 "tyrosine + tRNA(Tyr) + ATP => Tyr-tRNA(Tyr) + AMP + pyrophosphate, Dictyostelium discoideum"
xref: RHEA:10223
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004832
name: valine-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H(+)." [EC:6.1.1.9, RHEA:10707]
subset: gosubset_prok
synonym: "L-valine:tRNAVal ligase (AMP-forming)" EXACT [EC:6.1.1.9]
synonym: "valine transfer ribonucleate ligase activity" EXACT [EC:6.1.1.9]
synonym: "valine translase activity" EXACT [EC:6.1.1.9]
synonym: "valyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.9]
synonym: "valyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.9]
synonym: "valyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.9]
synonym: "valyl-tRNA synthetase activity" EXACT []
xref: EC:6.1.1.9
xref: KEGG:R03665
xref: MetaCyc:VALINE--TRNA-LIGASE-RXN
xref: Reactome:REACT_106454 "valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_107025 "valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_114299 "valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate, Mycobacterium tuberculosis"
xref: Reactome:REACT_15329 "valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate, Homo sapiens"
xref: Reactome:REACT_15429 "valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate, Homo sapiens"
xref: Reactome:REACT_28608 "valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate, Plasmodium falciparum"
xref: Reactome:REACT_30289 "valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate, Escherichia coli"
xref: Reactome:REACT_31528 "valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate, Oryza sativa"
xref: Reactome:REACT_80438 "valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate, Drosophila melanogaster"
xref: Reactome:REACT_83140 "valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate, Rattus norvegicus"
xref: Reactome:REACT_83206 "valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate, Xenopus tropicalis"
xref: Reactome:REACT_85723 "valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate, Arabidopsis thaliana"
xref: Reactome:REACT_87635 "valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate, Caenorhabditis elegans"
xref: Reactome:REACT_88236 "valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate, Danio rerio"
xref: Reactome:REACT_91856 "valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate, Canis familiaris"
xref: Reactome:REACT_96226 "valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate, Bos taurus"
xref: Reactome:REACT_97880 "valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate, Mus musculus"
xref: Reactome:REACT_98363 "valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate, Dictyostelium discoideum"
xref: RHEA:10707
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004833
name: tryptophan 2,3-dioxygenase activity
namespace: molecular_function
alt_id: GO:0004426
def: "Catalysis of the reaction: L-tryptophan + O2 = N-formyl-L-kynurenine." [EC:1.13.11.11]
subset: gosubset_prok
synonym: "indolamine 2,3-dioxygenase activity" BROAD [EC:1.13.11.11]
synonym: "indoleamine-pyrrole 2,3-dioxygenase activity" EXACT []
synonym: "L-tryptophan 2,3-dioxygenase activity" EXACT [EC:1.13.11.11]
synonym: "L-tryptophan pyrrolase activity" EXACT [EC:1.13.11.11]
synonym: "L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.11]
synonym: "TDO" RELATED [EC:1.13.11.11]
synonym: "tryptamin 2,3-dioxygenase activity" EXACT [EC:1.13.11.11]
synonym: "tryptamine 2,3-dioxygenase activity" EXACT [EC:1.13.11.11]
synonym: "tryptophan oxygenase activity" BROAD [EC:1.13.11.11]
synonym: "tryptophan peroxidase activity" BROAD [EC:1.13.11.11]
synonym: "tryptophan pyrrolase activity" BROAD [EC:1.13.11.11]
xref: EC:1.13.11.11
xref: MetaCyc:TRYPTOPHAN-23-DIOXYGENASE-RXN
xref: Reactome:REACT_1007 "tryptophan + O2 => N-formylkynurenine [TDO], Homo sapiens"
xref: Reactome:REACT_102060 "tryptophan + O2 => N-formylkynurenine [IDO], Rattus norvegicus"
xref: Reactome:REACT_102590 "tryptophan + O2 => N-formylkynurenine [IDO2], Xenopus tropicalis"
xref: Reactome:REACT_104715 "tryptophan + O2 => N-formylkynurenine [TDO], Canis familiaris"
xref: Reactome:REACT_106515 "tryptophan + O2 => N-formylkynurenine [TDO], Rattus norvegicus"
xref: Reactome:REACT_107152 "tryptophan + O2 => N-formylkynurenine [TDO], Bos taurus"
xref: Reactome:REACT_107976 "tryptophan + O2 => N-formylkynurenine [IDO2], Canis familiaris"
xref: Reactome:REACT_108462 "tryptophan + O2 => N-formylkynurenine [IDO2], Saccharomyces cerevisiae"
xref: Reactome:REACT_108599 "tryptophan + O2 => N-formylkynurenine [TDO], Xenopus tropicalis"
xref: Reactome:REACT_109904 "tryptophan + O2 => N-formylkynurenine [TDO], Danio rerio"
xref: Reactome:REACT_110088 "tryptophan + O2 => N-formylkynurenine [TDO], Dictyostelium discoideum"
xref: Reactome:REACT_11113 "tryptophan + O2 => N-formylkynurenine [IDO], Homo sapiens"
xref: Reactome:REACT_23860 "tryptophan + O2 => N-formylkynurenine [IDO2], Homo sapiens"
xref: Reactome:REACT_31732 "tryptophan + O2 => N-formylkynurenine [TDO], Drosophila melanogaster"
xref: Reactome:REACT_32222 "tryptophan + O2 => N-formylkynurenine [TDO], Sus scrofa"
xref: Reactome:REACT_34390 "tryptophan + O2 => N-formylkynurenine [IDO2], Taeniopygia guttata"
xref: Reactome:REACT_70247 "tryptophan + O2 => N-formylkynurenine [IDO], Saccharomyces cerevisiae"
xref: Reactome:REACT_76928 "tryptophan + O2 => N-formylkynurenine [TDO], Mus musculus"
xref: Reactome:REACT_77554 "tryptophan + O2 => N-formylkynurenine [TDO], Caenorhabditis elegans"
xref: Reactome:REACT_80543 "tryptophan + O2 => N-formylkynurenine [IDO2], Danio rerio"
xref: Reactome:REACT_88052 "tryptophan + O2 => N-formylkynurenine [IDO], Bos taurus"
xref: Reactome:REACT_88475 "tryptophan + O2 => N-formylkynurenine [IDO], Sus scrofa"
xref: Reactome:REACT_88694 "tryptophan + O2 => N-formylkynurenine [TDO], Gallus gallus"
xref: Reactome:REACT_89408 "tryptophan + O2 => N-formylkynurenine [IDO2], Rattus norvegicus"
xref: Reactome:REACT_91503 "tryptophan + O2 => N-formylkynurenine [IDO2], Gallus gallus"
xref: Reactome:REACT_91751 "tryptophan + O2 => N-formylkynurenine [IDO2], Mus musculus"
xref: Reactome:REACT_94106 "tryptophan + O2 => N-formylkynurenine [TDO], Taeniopygia guttata"
xref: Reactome:REACT_96147 "tryptophan + O2 => N-formylkynurenine [IDO2], Bos taurus"
xref: Reactome:REACT_98242 "tryptophan + O2 => N-formylkynurenine [IDO], Canis familiaris"
xref: Reactome:REACT_99321 "tryptophan + O2 => N-formylkynurenine [IDO], Mus musculus"
xref: RHEA:24539
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0004834
name: tryptophan synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-serine + (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O." [RHEA:10535]
subset: gosubset_prok
synonym: "indoleglycerol phosphate aldolase activity" EXACT [EC:4.2.1.20]
synonym: "L-serine hydro-lyase (adding indoleglycerol-phosphate)" EXACT [EC:4.2.1.20]
synonym: "L-serine hydro-lyase [adding 1-C-(indol-3-yl)glycerol 3-phosphate; L-tryptophan and glyceraldehyde-3-phosphate-forming]" RELATED [EC:4.2.1.20]
synonym: "L-tryptophan synthetase activity" EXACT [EC:4.2.1.20]
synonym: "tryptophan desmolase activity" EXACT [EC:4.2.1.20]
synonym: "tryptophan synthetase activity" EXACT [EC:4.2.1.20]
xref: EC:4.2.1.20
xref: KEGG:R02722
xref: MetaCyc:TRYPSYN-RXN
xref: RHEA:10535
is_a: GO:0016836 ! hydro-lyase activity
relationship: part_of GO:0000162 ! tryptophan biosynthetic process

[Term]
id: GO:0004835
name: tubulin-tyrosine ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate." [EC:6.3.2.25]
synonym: "alpha-tubulin:L-tyrosine ligase (ADP-forming)" EXACT [EC:6.3.2.25]
synonym: "TTL activity" EXACT [EC:6.3.2.25]
synonym: "tubulinyl-tyrosine ligase activity" EXACT []
xref: EC:6.3.2.25
xref: MetaCyc:6.3.2.25-RXN
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0004836
name: tyramine-beta hydroxylase activity
namespace: molecular_function
def: "Catalysis of the hydroxylation of tyramine to form octopamine." [PMID:10745161]
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0004837
name: tyrosine decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tyrosine = tyramine + CO2." [EC:4.1.1.25]
synonym: "L-(-)-tyrosine apodecarboxylase activity" EXACT [EC:4.1.1.25]
synonym: "L-tyrosine carboxy-lyase (tyramine-forming)" EXACT [EC:4.1.1.25]
synonym: "L-tyrosine carboxy-lyase activity" EXACT [EC:4.1.1.25]
synonym: "L-tyrosine decarboxylase activity" EXACT [EC:4.1.1.25]
xref: EC:4.1.1.25
xref: MetaCyc:TYROSINE-DECARBOXYLASE-RXN
xref: RHEA:14348
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004838
name: L-tyrosine:2-oxoglutarate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate." [EC:2.6.1.5]
subset: gosubset_prok
synonym: "glutamic phenylpyruvic aminotransferase activity" RELATED [EC:2.6.1.5]
synonym: "glutamic-hydroxyphenylpyruvic transaminase activity" RELATED [EC:2.6.1.5]
synonym: "L-phenylalanine 2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.5]
synonym: "L-tyrosine aminotransferase activity" BROAD [EC:2.6.1.5]
synonym: "phenylalanine aminotransferase activity" RELATED [EC:2.6.1.5]
synonym: "phenylalanine transaminase activity" RELATED [EC:2.6.1.5]
synonym: "phenylalanine-alpha-ketoglutarate transaminase activity" RELATED [EC:2.6.1.5]
synonym: "phenylpyruvate transaminase activity" RELATED [EC:2.6.1.5]
synonym: "phenylpyruvic acid transaminase activity" RELATED [EC:2.6.1.5]
synonym: "TyrAT activity" RELATED [EC:2.6.1.5]
synonym: "tyrosine aminotransferase activity" BROAD []
synonym: "tyrosine transaminase activity" BROAD [EC:2.6.1.5]
synonym: "tyrosine-2-ketoglutarate aminotransferase activity" BROAD [EC:2.6.1.5]
synonym: "tyrosine-alpha-ketoglutarate aminotransferase activity" BROAD [EC:2.6.1.5]
synonym: "tyrosine-alpha-ketoglutarate transaminase activity" BROAD [EC:2.6.1.5]
xref: EC:2.6.1.5
xref: MetaCyc:TYROSINE-AMINOTRANSFERASE-RXN
xref: Reactome:REACT_107895 "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate, Arabidopsis thaliana"
xref: Reactome:REACT_21382 "p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate, Homo sapiens"
xref: Reactome:REACT_28271 "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate, Danio rerio"
xref: Reactome:REACT_28499 "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate, Staphylococcus aureus N315"
xref: Reactome:REACT_31573 "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate, Escherichia coli"
xref: Reactome:REACT_33184 "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate, Caenorhabditis elegans"
xref: Reactome:REACT_33742 "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate, Gallus gallus"
xref: Reactome:REACT_690 "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate, Homo sapiens"
xref: Reactome:REACT_80827 "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate, Drosophila melanogaster"
xref: Reactome:REACT_83554 "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate, Mycobacterium tuberculosis"
xref: Reactome:REACT_87869 "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate, Rattus norvegicus"
xref: Reactome:REACT_89583 "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate, Xenopus tropicalis"
xref: Reactome:REACT_91153 "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate, Dictyostelium discoideum"
xref: Reactome:REACT_91471 "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate, Mus musculus"
xref: Reactome:REACT_93645 "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate, Canis familiaris"
xref: Reactome:REACT_94575 "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate, Sus scrofa"
xref: Reactome:REACT_95555 "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate, Taeniopygia guttata"
xref: Reactome:REACT_96541 "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate, Bos taurus"
xref: Reactome:REACT_99000 "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate, Oryza sativa"
is_a: GO:0070547 ! L-tyrosine aminotransferase activity

[Term]
id: GO:0004839
name: ubiquitin activating enzyme activity
namespace: molecular_function
def: "Catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate." [GOC:BioGRID, http://www.bostonbiochem.com/E-301.html, PMID:10072378]
synonym: "E1" EXACT []
xref: Wikipedia:Ubiquitin-activating_enzyme
is_a: GO:0008641 ! small protein activating enzyme activity
relationship: part_of GO:0016567 ! protein ubiquitination

[Term]
id: GO:0004842
name: ubiquitin-protein transferase activity
namespace: molecular_function
alt_id: GO:0004840
alt_id: GO:0004841
def: "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
synonym: "anaphase-promoting complex activity" NARROW [GOC:dph, GOC:tb]
synonym: "E2" RELATED []
synonym: "E3" RELATED []
synonym: "ubiquitin conjugating enzyme activity" NARROW []
synonym: "ubiquitin ligase activity" NARROW []
synonym: "ubiquitin protein ligase activity" NARROW []
synonym: "ubiquitin protein-ligase activity" NARROW []
synonym: "ubiquitin-conjugating enzyme activity" NARROW []
xref: KEGG:R03876
xref: MetaCyc:UBIQUITIN--PROTEIN-LIGASE-RXN
xref: Reactome:REACT_100004 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex, Canis familiaris"
xref: Reactome:REACT_100102 "Ubiquitination of stimulated EGFR (CBL:GRB2), Rattus norvegicus"
xref: Reactome:REACT_100126 "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8, Taeniopygia guttata"
xref: Reactome:REACT_100359 "Monoubiquitination of FANCI by the FA ubiquitin ligase complex, Mus musculus"
xref: Reactome:REACT_100699 "Activated TRAF6 recruits TAK1complex by binding to ubiquitin receptors of TAB2/TAB3, Sus scrofa"
xref: Reactome:REACT_100823 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex, Mus musculus"
xref: Reactome:REACT_100856 "CBL ubiquitinates Sprouty, Danio rerio"
xref: Reactome:REACT_101110 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex, Mus musculus"
xref: Reactome:REACT_101216 "CBL ubiquitinates Sprouty, Rattus norvegicus"
xref: Reactome:REACT_101217 "CBL binds and ubiquitinates phosphorylated Sprouty, Rattus norvegicus"
xref: Reactome:REACT_101822 "Ubiquitin-dependent degradation controls basal levels of SMAD2/3, Mus musculus"
xref: Reactome:REACT_101849 "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8, Drosophila melanogaster"
xref: Reactome:REACT_102186 "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8, Xenopus tropicalis"
xref: Reactome:REACT_102220 "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling, Xenopus tropicalis"
xref: Reactome:REACT_102841 "Ubiquitination of stimulated EGFR (CBL:GRB2), Bos taurus"
xref: Reactome:REACT_103261 "Autoubiquitination of phospho-COP1(Ser-387 ), Bos taurus"
xref: Reactome:REACT_103376 "Ubiquitin-dependent degradation controls basal levels of SMAD2/3, Taeniopygia guttata"
xref: Reactome:REACT_103483 "Ubiquitination of PER Proteins, Gallus gallus"
xref: Reactome:REACT_103721 "CBL-mediated ubiquitination of CIN85, Rattus norvegicus"
xref: Reactome:REACT_103809 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex, Xenopus tropicalis"
xref: Reactome:REACT_104185 "Monoubiquitination of FANCD2 by the FA ubiquitin ligase complex, Canis familiaris"
xref: Reactome:REACT_104518 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex, Taeniopygia guttata"
xref: Reactome:REACT_104803 "CBL ubiquitinates Sprouty, Canis familiaris"
xref: Reactome:REACT_104984 "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8, Danio rerio"
xref: Reactome:REACT_104994 "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling, Mus musculus"
xref: Reactome:REACT_105370 "Multiubiquitination of APC/C-associated Cdh1, Danio rerio"
xref: Reactome:REACT_105620 "Multiubiquitination of APC/C-associated Cdh1, Taeniopygia guttata"
xref: Reactome:REACT_106156 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex, Rattus norvegicus"
xref: Reactome:REACT_106407 "CBL binds and ubiquitinates phosphorylated Sprouty, Mus musculus"
xref: Reactome:REACT_106416 "Ubiquitin-dependent degradation controls basal levels of SMAD2/3, Sus scrofa"
xref: Reactome:REACT_106527 "Ubiquitin-dependent degradation controls basal levels of SMAD2/3, Gallus gallus"
xref: Reactome:REACT_106906 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex, Xenopus tropicalis"
xref: Reactome:REACT_107379 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex, Xenopus tropicalis"
xref: Reactome:REACT_107643 "Ubiquitination of phospho-p27/p21, Danio rerio"
xref: Reactome:REACT_107829 "Multiubiquitination of APC/C-associated Cdh1, Rattus norvegicus"
xref: Reactome:REACT_108396 "TRAF6 polyubiquitinates NRIF, Bos taurus"
xref: Reactome:REACT_108446 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex, Danio rerio"
xref: Reactome:REACT_108589 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex, Mus musculus"
xref: Reactome:REACT_108657 "Activated TRAF6 recruits TAK1complex by binding to ubiquitin receptors of TAB2/TAB3, Danio rerio"
xref: Reactome:REACT_109007 "Monoubiquitination of FANCD2 by the FA ubiquitin ligase complex, Gallus gallus"
xref: Reactome:REACT_109071 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex, Drosophila melanogaster"
xref: Reactome:REACT_109354 "Ubiquitination of Emi1 by SCF-beta-TrCP, Rattus norvegicus"
xref: Reactome:REACT_109539 "Ubiquitination of Emi1 by SCF-beta-TrCP, Canis familiaris"
xref: Reactome:REACT_109637 "Autoubiquitination of phospho-COP1(Ser-387 ), Oryza sativa"
xref: Reactome:REACT_109798 "CBL-mediated ubiquitination of CIN85, Mus musculus"
xref: Reactome:REACT_110158 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex, Gallus gallus"
xref: Reactome:REACT_110535 "Autoubiquitination of phospho-COP1(Ser-387 ), Xenopus tropicalis"
xref: Reactome:REACT_110749 "Activated TRAF6 recruits TAK1complex by binding to ubiquitin receptors of TAB2/TAB3, Rattus norvegicus"
xref: Reactome:REACT_111089 "Ubiquitination of p130 (RBL2) by SCF (Skp2), Homo sapiens"
xref: Reactome:REACT_111141 "Phosphorylated SPRY2 is ubiquitinated by CBL, Homo sapiens"
xref: Reactome:REACT_111231 "CBL ubiquitinates FRS2 and FGFR, Homo sapiens"
xref: Reactome:REACT_112355 "Auto-ubiquitination of TRAF6, Bos taurus"
xref: Reactome:REACT_112414 "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling, Danio rerio"
xref: Reactome:REACT_112448 "Ubiquitination of NEMO by TRAF6, Xenopus tropicalis"
xref: Reactome:REACT_112669 "CBL ubiquitinates Sprouty, Drosophila melanogaster"
xref: Reactome:REACT_113192 "CBL ubiquitinates Sprouty, Bos taurus"
xref: Reactome:REACT_113956 "Monoubiquitination of FANCI by the FA ubiquitin ligase complex, Xenopus tropicalis"
xref: Reactome:REACT_114042 "Auto-ubiquitination of TRAF6, Gallus gallus"
xref: Reactome:REACT_114074 "CBL ubiquitinates Sprouty, Gallus gallus"
xref: Reactome:REACT_114376 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex, Oryza sativa"
xref: Reactome:REACT_114678 "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling, Danio rerio"
xref: Reactome:REACT_115172 "Multiubiquitination of Nek2A, Dictyostelium discoideum"
xref: Reactome:REACT_115175 "Ubiquitination of NEMO by TRAF6, Bos taurus"
xref: Reactome:REACT_115543 "ISGylation of E2 conjugating enzymes, Homo sapiens"
xref: Reactome:REACT_115557 "CUL5 mediates ubiquitination of ERBB2, Homo sapiens"
xref: Reactome:REACT_115599 "RNF41 ubiquitinates activated ERBB3, Homo sapiens"
xref: Reactome:REACT_115658 "ISGylation of host protein filamin B, Homo sapiens"
xref: Reactome:REACT_115732 "Inefficient ubiquitination of ligand-responsive EGFR mutants by phosphorylated CBL, Homo sapiens"
xref: Reactome:REACT_115802 "Monoubiquitination of FancD2, Gallus gallus"
xref: Reactome:REACT_115843 "ISGylation of protein phosphatase 1 beta (PP2CB), Homo sapiens"
xref: Reactome:REACT_115889 "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer, Homo sapiens"
xref: Reactome:REACT_115890 "ISGylation of host proteins, Homo sapiens"
xref: Reactome:REACT_115934 "ISGylation of IRF3, Homo sapiens"
xref: Reactome:REACT_115952 "RNF41 ubiquitinates ERBB3, Homo sapiens"
xref: Reactome:REACT_115963 "Self-ubiquitination of RNF41, Homo sapiens"
xref: Reactome:REACT_115965 "ISGylation of viral protein NS1, Homo sapiens"
xref: Reactome:REACT_116015 "CHIP (STUB1) mediates ubiquitination of ERBB2, Homo sapiens"
xref: Reactome:REACT_116054 "ERBB4 ubiquitination by WWP1/ITCH, Homo sapiens"
xref: Reactome:REACT_116086 "Monoubiquitination of PCNA, Gallus gallus"
xref: Reactome:REACT_116132 "Activation of ISG15 by UBE1L E1 ligase, Homo sapiens"
xref: Reactome:REACT_12038 "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8, Homo sapiens"
xref: Reactome:REACT_12048 "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling, Homo sapiens"
xref: Reactome:REACT_12381 "CBL ubiquitinates Sprouty, Homo sapiens"
xref: Reactome:REACT_12432 "CBL binds and ubiquitinates phosphorylated Sprouty, Homo sapiens"
xref: Reactome:REACT_12451 "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix, Homo sapiens"
xref: Reactome:REACT_12515 "Ubiquitination of stimulated EGFR (CBL), Homo sapiens"
xref: Reactome:REACT_12520 "CBL-mediated ubiquitination of CIN85, Homo sapiens"
xref: Reactome:REACT_12553 "Ubiquitination of NEMO by TRAF6, Homo sapiens"
xref: Reactome:REACT_12562 "Ubiquitination of stimulated EGFR (CBL:GRB2), Homo sapiens"
xref: Reactome:REACT_12595 "Auto-ubiquitination of TRAF6, Homo sapiens"
xref: Reactome:REACT_13487 "Ubiquitination of PAK-2p34, Oryctolagus cuniculus"
xref: Reactome:REACT_13488 "TRAF6 polyubiquitinates NRIF, Homo sapiens"
xref: Reactome:REACT_13600 "Ubiquitination of PAK-2p34, Homo sapiens"
xref: Reactome:REACT_18367 "Monoubiquitination of FANCI by the FA ubiquitin ligase complex, Homo sapiens"
xref: Reactome:REACT_18429 "Monoubiquitination of FANCD2 by the FA ubiquitin ligase complex, Homo sapiens"
xref: Reactome:REACT_20581 "Autoubiquitination of phospho-COP1(Ser-387 ), Homo sapiens"
xref: Reactome:REACT_21364 "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation, Homo sapiens"
xref: Reactome:REACT_22381 "Pellino ubiquitinates IRAK1, Homo sapiens"
xref: Reactome:REACT_22407 "Beta-TrCP ubiquitinates then dissociates from p-NFKB p105, Homo sapiens"
xref: Reactome:REACT_22430 "TRAF6 auto-ubiquitinates with Lys63-linked polyubiquitin chains, Homo sapiens"
xref: Reactome:REACT_24932 "PIN1 mediated IRF3 degradation, Homo sapiens"
xref: Reactome:REACT_24996 "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane, Homo sapiens"
xref: Reactome:REACT_25022 "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2, Homo sapiens"
xref: Reactome:REACT_25090 "TRAF6 ubiquitinqtes IRF7 in a K63-dependent manner following TLR7/8 or 9 stimulation, Homo sapiens"
xref: Reactome:REACT_25128 "Auto ubiquitination of oligo TRAF6 bound to p-IRAK2, Gallus gallus"
xref: Reactome:REACT_25143 "Ubiquitination of PER Proteins, Homo sapiens"
xref: Reactome:REACT_25177 "RNF125 mediated ubiquitination of RIG-I, MDA5 and IPS-1, Mus musculus"
xref: Reactome:REACT_25220 "K-63-linked polyubiquitination of RIG-I, Homo sapiens"
xref: Reactome:REACT_25252 "RNF125 mediated ubiquitination of RIG-I, MDA5 and IPS-1, Homo sapiens"
xref: Reactome:REACT_25317 "Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex dsRNA :TLR3 :TIKAM1, Gallus gallus"
xref: Reactome:REACT_25362 "Activated TRAF6 synthesizes unanchored polyubiquitin chains, Homo sapiens"
xref: Reactome:REACT_25377 "Auto ubiquitination of the TRAF6 within the complex viral dsRNA:TLR3:TIKAM1:TRAF6, Gallus gallus"
xref: Reactome:REACT_25386 "Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex p-IRAK2:pUb_oligo TRAF6, Gallus gallus"
xref: Reactome:REACT_25398 "Recruitment of AIP4 and K-48 ubiquitination of MAVS/IPS-1, Homo sapiens"
xref: Reactome:REACT_27202 "Autoubiquitination of oligoTRAF6 bound to p-IRAK2, Gallus gallus"
xref: Reactome:REACT_28038 "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8, Mus musculus"
xref: Reactome:REACT_28057 "Ubiquitination of NEMO by TRAF6, Danio rerio"
xref: Reactome:REACT_28632 "Monoubiquitination of FANCI by the FA ubiquitin ligase complex, Gallus gallus"
xref: Reactome:REACT_28669 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex, Drosophila melanogaster"
xref: Reactome:REACT_28992 "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling, Bos taurus"
xref: Reactome:REACT_29045 "CBL ubiquitinates Sprouty, Xenopus tropicalis"
xref: Reactome:REACT_30173 "Monoubiquitination of FANCI by the FA ubiquitin ligase complex, Danio rerio"
xref: Reactome:REACT_30590 "Ubiquitination of PER Proteins, Rattus norvegicus"
xref: Reactome:REACT_30651 "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8, Canis familiaris"
xref: Reactome:REACT_30747 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex, Bos taurus"
xref: Reactome:REACT_31133 "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling, Bos taurus"
xref: Reactome:REACT_31520 "TRAF6 polyubiquitinates NRIF, Gallus gallus"
xref: Reactome:REACT_31622 "Monoubiquitination of FANCD2 by the FA ubiquitin ligase complex, Mus musculus"
xref: Reactome:REACT_31985 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex, Danio rerio"
xref: Reactome:REACT_32642 "CBL ubiquitinates Sprouty, Taeniopygia guttata"
xref: Reactome:REACT_32728 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex, Gallus gallus"
xref: Reactome:REACT_32748 "Multiubiquitination of APC/C-associated Cdh1, Mus musculus"
xref: Reactome:REACT_33018 "Auto-ubiquitination of TRAF6, Xenopus tropicalis"
xref: Reactome:REACT_33373 "Monoubiquitination of FANCI by the FA ubiquitin ligase complex, Taeniopygia guttata"
xref: Reactome:REACT_33406 "Ubiquitination of NEMO by TRAF6, Mus musculus"
xref: Reactome:REACT_33468 "Multiubiquitination of APC/C-associated Cdh1, Bos taurus"
xref: Reactome:REACT_33488 "CBL binds and ubiquitinates phosphorylated Sprouty, Danio rerio"
xref: Reactome:REACT_34498 "Multiubiquitination of Nek2A, Taeniopygia guttata"
xref: Reactome:REACT_62571 "Ubiquitination of stimulated EGFR (CBL:GRB2), Gallus gallus"
xref: Reactome:REACT_6723 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex, Homo sapiens"
xref: Reactome:REACT_6735 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex, Homo sapiens"
xref: Reactome:REACT_6786 "Ubiquitin-dependent degradation controls basal levels of SMAD2/3, Homo sapiens"
xref: Reactome:REACT_6791 "Multiubiquitination of APC/C-associated Cdh1, Homo sapiens"
xref: Reactome:REACT_6824 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex, Homo sapiens"
xref: Reactome:REACT_6827 "Ubiquitination of Emi1 by SCF-beta-TrCP, Homo sapiens"
xref: Reactome:REACT_6857 "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling, Homo sapiens"
xref: Reactome:REACT_6914 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex, Homo sapiens"
xref: Reactome:REACT_6921 "Activated TRAF6 recruits TAK1complex by binding to ubiquitin receptors of TAB2/TAB3, Homo sapiens"
xref: Reactome:REACT_715 "Ubiquitination of Cyclin D1, Homo sapiens"
xref: Reactome:REACT_75782 "E1 mediated ubiquitin activation, Homo sapiens"
xref: Reactome:REACT_75847 "Polyubiquitination of substrate, Homo sapiens"
xref: Reactome:REACT_75901 "Transfer of Ub from E2 to substrate and release of E2, Homo sapiens"
xref: Reactome:REACT_75924 "RIP2 induces K63-linked ubiquitination of NEMO, Homo sapiens"
xref: Reactome:REACT_76990 "Autoubiquitination of phospho-COP1(Ser-387 ), Gallus gallus"
xref: Reactome:REACT_77058 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex, Bos taurus"
xref: Reactome:REACT_78171 "Ubiquitin-dependent degradation controls basal levels of SMAD2/3, Canis familiaris"
xref: Reactome:REACT_78216 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex, Rattus norvegicus"
xref: Reactome:REACT_78347 "Ubiquitination of PER Proteins, Canis familiaris"
xref: Reactome:REACT_78373 "Ubiquitination of stimulated EGFR (CBL), Xenopus tropicalis"
xref: Reactome:REACT_78391 "TRAF6 polyubiquitinates NRIF, Mus musculus"
xref: Reactome:REACT_78475 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex, Taeniopygia guttata"
xref: Reactome:REACT_79393 "Multiubiquitination of APC/C-associated Cdh1, Drosophila melanogaster"
xref: Reactome:REACT_79631 "Autoubiquitination of phospho-COP1(Ser-387 ), Danio rerio"
xref: Reactome:REACT_79673 "Ubiquitination of phospho-p27/p21, Rattus norvegicus"
xref: Reactome:REACT_79773 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex, Xenopus tropicalis"
xref: Reactome:REACT_79781 "Multiubiquitination of APC/C-associated Cdh1, Oryza sativa"
xref: Reactome:REACT_7995 "Multiubiquitination of Nek2A, Homo sapiens"
xref: Reactome:REACT_80157 "Multiubiquitination of APC/C-associated Cdh1, Xenopus tropicalis"
xref: Reactome:REACT_80228 "Monoubiquitination of FANCI by the FA ubiquitin ligase complex, Rattus norvegicus"
xref: Reactome:REACT_80230 "Auto-ubiquitination of TRAF6, Mus musculus"
xref: Reactome:REACT_80243 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex, Taeniopygia guttata"
xref: Reactome:REACT_80572 "CBL-mediated ubiquitination of CIN85, Taeniopygia guttata"
xref: Reactome:REACT_80798 "Autoubiquitination of phospho-COP1(Ser-387 ), Canis familiaris"
xref: Reactome:REACT_80813 "Ubiquitin-dependent degradation controls basal levels of SMAD2/3, Rattus norvegicus"
xref: Reactome:REACT_81041 "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix, Mus musculus"
xref: Reactome:REACT_81332 "Ubiquitination of phospho-p27/p21, Mus musculus"
xref: Reactome:REACT_81489 "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8, Bos taurus"
xref: Reactome:REACT_81526 "Ubiquitin-dependent degradation controls basal levels of SMAD2/3, Bos taurus"
xref: Reactome:REACT_81796 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex, Canis familiaris"
xref: Reactome:REACT_81809 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex, Gallus gallus"
xref: Reactome:REACT_82103 "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling, Sus scrofa"
xref: Reactome:REACT_82502 "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling, Xenopus tropicalis"
xref: Reactome:REACT_82956 "CBL-mediated ubiquitination of CIN85, Bos taurus"
xref: Reactome:REACT_83121 "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling, Drosophila melanogaster"
xref: Reactome:REACT_83886 "Ubiquitination of Emi1 by SCF-beta-TrCP, Mus musculus"
xref: Reactome:REACT_83914 "Ubiquitination of phospho-p27/p21, Bos taurus"
xref: Reactome:REACT_84110 "Multiubiquitination of Nek2A, Drosophila melanogaster"
xref: Reactome:REACT_84282 "Ubiquitination of stimulated EGFR (CBL), Danio rerio"
xref: Reactome:REACT_84479 "Multiubiquitination of Nek2A, Rattus norvegicus"
xref: Reactome:REACT_84482 "Multiubiquitination of Nek2A, Xenopus tropicalis"
xref: Reactome:REACT_84826 "Ubiquitination of stimulated EGFR (CBL), Mus musculus"
xref: Reactome:REACT_85057 "Autoubiquitination of phospho-COP1(Ser-387 ), Taeniopygia guttata"
xref: Reactome:REACT_85163 "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling, Rattus norvegicus"
xref: Reactome:REACT_85194 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex, Drosophila melanogaster"
xref: Reactome:REACT_85337 "CBL binds and ubiquitinates phosphorylated Sprouty, Canis familiaris"
xref: Reactome:REACT_85348 "CBL-mediated ubiquitination of CIN85, Gallus gallus"
xref: Reactome:REACT_85498 "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8, Rattus norvegicus"
xref: Reactome:REACT_86043 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex, Danio rerio"
xref: Reactome:REACT_86192 "Ubiquitination of phospho-p27/p21, Canis familiaris"
xref: Reactome:REACT_86281 "Ubiquitination of Emi1 by SCF-beta-TrCP, Bos taurus"
xref: Reactome:REACT_86879 "Ubiquitin-dependent degradation controls basal levels of SMAD2/3, Danio rerio"
xref: Reactome:REACT_87217 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex, Gallus gallus"
xref: Reactome:REACT_87236 "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling, Mus musculus"
xref: Reactome:REACT_87349 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex, Taeniopygia guttata"
xref: Reactome:REACT_87486 "Monoubiquitination of FANCI by the FA ubiquitin ligase complex, Bos taurus"
xref: Reactome:REACT_87663 "Multiubiquitination of Nek2A, Gallus gallus"
xref: Reactome:REACT_87845 "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling, Rattus norvegicus"
xref: Reactome:REACT_88589 "Autoubiquitination of phospho-COP1(Ser-387 ), Rattus norvegicus"
xref: Reactome:REACT_88911 "CBL ubiquitinates Sprouty, Mus musculus"
xref: Reactome:REACT_88971 "Monoubiquitination of FANCD2 by the FA ubiquitin ligase complex, Rattus norvegicus"
xref: Reactome:REACT_89066 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex, Mus musculus"
xref: Reactome:REACT_89086 "Ubiquitination of stimulated EGFR (CBL), Canis familiaris"
xref: Reactome:REACT_89128 "TRAF6 polyubiquitinates NRIF, Rattus norvegicus"
xref: Reactome:REACT_89304 "Ubiquitination of Emi1 by SCF-beta-TrCP, Drosophila melanogaster"
xref: Reactome:REACT_89324 "CBL-mediated ubiquitination of CIN85, Danio rerio"
xref: Reactome:REACT_89540 "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling, Drosophila melanogaster"
xref: Reactome:REACT_9026 "Ubiquitination of phospho-p27/p21, Homo sapiens"
xref: Reactome:REACT_90441 "CBL-mediated ubiquitination of CIN85, Canis familiaris"
xref: Reactome:REACT_90505 "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8, Gallus gallus"
xref: Reactome:REACT_9063 "Ubiquitination of CD4 by Vpu:CD4:beta-TrCP:SKP1 complex, Homo sapiens"
xref: Reactome:REACT_90742 "Ubiquitination of PER Proteins, Drosophila melanogaster"
xref: Reactome:REACT_90880 "Monoubiquitination of FANCD2 by the FA ubiquitin ligase complex, Danio rerio"
xref: Reactome:REACT_91216 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex, Oryza sativa"
xref: Reactome:REACT_91336 "Multiubiquitination of APC/C-associated Cdh1, Gallus gallus"
xref: Reactome:REACT_91446 "Ubiquitination of stimulated EGFR (CBL:GRB2), Xenopus tropicalis"
xref: Reactome:REACT_91686 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex, Bos taurus"
xref: Reactome:REACT_91754 "Multiubiquitination of Nek2A, Danio rerio"
xref: Reactome:REACT_91854 "Activated TRAF6 recruits TAK1complex by binding to ubiquitin receptors of TAB2/TAB3, Bos taurus"
xref: Reactome:REACT_91885 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex, Rattus norvegicus"
xref: Reactome:REACT_92022 "Multiubiquitination of Nek2A, Bos taurus"
xref: Reactome:REACT_92097 "Activated TRAF6 recruits TAK1complex by binding to ubiquitin receptors of TAB2/TAB3, Gallus gallus"
xref: Reactome:REACT_92278 "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix, Rattus norvegicus"
xref: Reactome:REACT_92341 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex, Dictyostelium discoideum"
xref: Reactome:REACT_92445 "CBL binds and ubiquitinates phosphorylated Sprouty, Xenopus tropicalis"
xref: Reactome:REACT_92638 "Autoubiquitination of phospho-COP1(Ser-387 ), Sus scrofa"
xref: Reactome:REACT_92641 "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling, Sus scrofa"
xref: Reactome:REACT_92734 "Autoubiquitination of phospho-COP1(Ser-387 ), Dictyostelium discoideum"
xref: Reactome:REACT_92878 "Multiubiquitination of APC/C-associated Cdh1, Canis familiaris"
xref: Reactome:REACT_93 "Ubiquitination of phosphorylated Cdc25A, Homo sapiens"
xref: Reactome:REACT_93088 "Autoubiquitination of phospho-COP1(Ser-387 ), Mus musculus"
xref: Reactome:REACT_93091 "Monoubiquitination of FANCI by the FA ubiquitin ligase complex, Canis familiaris"
xref: Reactome:REACT_93808 "Ubiquitination of stimulated EGFR (CBL:GRB2), Danio rerio"
xref: Reactome:REACT_93823 "Ubiquitination of PER Proteins, Xenopus tropicalis"
xref: Reactome:REACT_93940 "CBL-mediated ubiquitination of CIN85, Drosophila melanogaster"
xref: Reactome:REACT_93965 "Monoubiquitination of FANCD2 by the FA ubiquitin ligase complex, Bos taurus"
xref: Reactome:REACT_94143 "TRAF6 polyubiquitinates NRIF, Taeniopygia guttata"
xref: Reactome:REACT_94165 "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix, Danio rerio"
xref: Reactome:REACT_94183 "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8, Sus scrofa"
xref: Reactome:REACT_94202 "Multiubiquitination of Nek2A, Canis familiaris"
xref: Reactome:REACT_94479 "Ubiquitination of PER Proteins, Bos taurus"
xref: Reactome:REACT_94486 "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling, Canis familiaris"
xref: Reactome:REACT_94525 "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix, Xenopus tropicalis"
xref: Reactome:REACT_94687 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex, Bos taurus"
xref: Reactome:REACT_9471 "Multi-ubiquitination of APOBEC3G, Homo sapiens"
xref: Reactome:REACT_94788 "Monoubiquitination of FANCD2 by the FA ubiquitin ligase complex, Taeniopygia guttata"
xref: Reactome:REACT_94789 "Ubiquitin-dependent degradation controls basal levels of SMAD2/3, Drosophila melanogaster"
xref: Reactome:REACT_94816 "Activated TRAF6 recruits TAK1complex by binding to ubiquitin receptors of TAB2/TAB3, Taeniopygia guttata"
xref: Reactome:REACT_94864 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex, Canis familiaris"
xref: Reactome:REACT_95005 "Ubiquitination of phospho-p27/p21, Sus scrofa"
xref: Reactome:REACT_95022 "Multiubiquitination of Nek2A, Mus musculus"
xref: Reactome:REACT_95267 "Ubiquitination of phospho-p27/p21, Xenopus tropicalis"
xref: Reactome:REACT_95302 "Ubiquitination of Emi1 by SCF-beta-TrCP, Taeniopygia guttata"
xref: Reactome:REACT_95501 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex, Canis familiaris"
xref: Reactome:REACT_95529 "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling, Canis familiaris"
xref: Reactome:REACT_95866 "Ubiquitination of stimulated EGFR (CBL:GRB2), Taeniopygia guttata"
xref: Reactome:REACT_96059 "Ubiquitination of stimulated EGFR (CBL:GRB2), Canis familiaris"
xref: Reactome:REACT_96134 "Activated TRAF6 recruits TAK1complex by binding to ubiquitin receptors of TAB2/TAB3, Xenopus tropicalis"
xref: Reactome:REACT_96591 "CBL-mediated ubiquitination of CIN85, Xenopus tropicalis"
xref: Reactome:REACT_96771 "Ubiquitin-dependent degradation controls basal levels of SMAD2/3, Xenopus tropicalis"
xref: Reactome:REACT_97330 "Ubiquitination of Emi1 by SCF-beta-TrCP, Xenopus tropicalis"
xref: Reactome:REACT_97494 "Ubiquitination of stimulated EGFR (CBL:GRB2), Mus musculus"
xref: Reactome:REACT_97971 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex, Drosophila melanogaster"
xref: Reactome:REACT_98364 "Auto-ubiquitination of TRAF6, Danio rerio"
xref: Reactome:REACT_98491 "Activated TRAF6 recruits TAK1complex by binding to ubiquitin receptors of TAB2/TAB3, Mus musculus"
xref: Reactome:REACT_98502 "Activated TRAF6 recruits TAK1complex by binding to ubiquitin receptors of TAB2/TAB3, Canis familiaris"
xref: Reactome:REACT_98894 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex, Rattus norvegicus"
xref: Reactome:REACT_98993 "Ubiquitination of PER Proteins, Taeniopygia guttata"
xref: Reactome:REACT_99285 "Ubiquitination of stimulated EGFR (CBL), Rattus norvegicus"
xref: Reactome:REACT_99567 "Ubiquitination of Emi1 by SCF-beta-TrCP, Gallus gallus"
xref: Reactome:REACT_99825 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex, Danio rerio"
is_a: GO:0019787 ! ubiquitin-like protein transferase activity
relationship: part_of GO:0016567 ! protein ubiquitination

[Term]
id: GO:0004843
name: thiol-dependent ubiquitin-specific protease activity
namespace: molecular_function
def: "Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin and another protein." [GOC:jh2, ISBN:0120793709]
synonym: "deubiquitinase" EXACT [GOC:vw, PMID:19261746]
synonym: "deubiquitinase activity" NARROW [GOC:bf]
synonym: "deubiquitinating enzyme" NARROW [PMID:19188440]
synonym: "deubiquitylase" EXACT [GOC:vw, PMID:15657442]
synonym: "ubiquitin C-terminal hydrolase activity" EXACT [EC:3.4.19.12]
synonym: "ubiquitin hydrolase activity" BROAD [GOC:rl]
synonym: "ubiquitin-specific protease activity" BROAD []
synonym: "UBP" NARROW []
synonym: "UCH2" NARROW []
xref: Reactome:REACT_100631 "FANCD2 deubiquitination by USP1/UAF1, Bos taurus"
xref: Reactome:REACT_115763 "Deubiquitination of RNF41 by P-USP8, Homo sapiens"
xref: Reactome:REACT_115791 "Deubiquitination of FancD2, Gallus gallus"
xref: Reactome:REACT_18350 "FANCD2 deubiquitination by USP1/UAF1, Homo sapiens"
xref: Reactome:REACT_29152 "FANCD2 deubiquitination by USP1/UAF1, Rattus norvegicus"
xref: Reactome:REACT_87211 "FANCD2 deubiquitination by USP1/UAF1, Canis familiaris"
xref: Reactome:REACT_92871 "FANCD2 deubiquitination by USP1/UAF1, Sus scrofa"
xref: Reactome:REACT_95549 "FANCD2 deubiquitination by USP1/UAF1, Mus musculus"
xref: Reactome:REACT_96729 "FANCD2 deubiquitination by USP1/UAF1, Danio rerio"
is_a: GO:0036459 ! thiol-dependent ubiquitinyl hydrolase activity

[Term]
id: GO:0004844
name: uracil DNA N-glycosylase activity
namespace: molecular_function
def: "Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine." [GOC:elh, GOC:pr, PMID:9224623]
subset: gosubset_prok
synonym: "uracil-DNA glycosylase activity" EXACT []
xref: EC:3.2.2.-
xref: Reactome:REACT_1015 "Cleavage of 5-hydroxyluracil by UNG2 glycosylase, Homo sapiens"
xref: Reactome:REACT_104182 "Cleavage of uracil by UNG2 glycosylase, Mus musculus"
xref: Reactome:REACT_104724 "Cleavage of uracil by UNG2 glycosylase, Sus scrofa"
xref: Reactome:REACT_105882 "Cleavage of 5-hydroxyluracil by UNG2 glycosylase, Sus scrofa"
xref: Reactome:REACT_107541 "Cleavage of 5-hydroxyluracil by UNG2 glycosylase, Xenopus tropicalis"
xref: Reactome:REACT_115592 "Cleavage of uracil by Uracil-glycosylase, Gallus gallus"
xref: Reactome:REACT_115960 "Uracil glycosylase mediated recognition and binding of uracil opposite guanine, Gallus gallus"
xref: Reactome:REACT_239 "Cleavage of uracil by UNG2 glycosylase, Homo sapiens"
xref: Reactome:REACT_32493 "Cleavage of uracil by UNG2 glycosylase, Rattus norvegicus"
xref: Reactome:REACT_79037 "Cleavage of uracil by UNG2 glycosylase, Canis familiaris"
xref: Reactome:REACT_79415 "Cleavage of 5-hydroxyluracil by UNG2 glycosylase, Canis familiaris"
xref: Reactome:REACT_80373 "Cleavage of 5-hydroxyluracil by UNG2 glycosylase, Mus musculus"
xref: Reactome:REACT_91708 "Cleavage of uracil by UNG2 glycosylase, Xenopus tropicalis"
xref: Reactome:REACT_92819 "Cleavage of 5-hydroxyluracil by UNG2 glycosylase, Rattus norvegicus"
is_a: GO:0097506 ! deaminated base DNA N-glycosylase activity

[Term]
id: GO:0004845
name: uracil phosphoribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil." [EC:2.4.2.9, RHEA:13020]
subset: gosubset_prok
synonym: "UMP diphosphorylase activity" EXACT [EC:2.4.2.9]
synonym: "UMP pyrophosphorylase activity" EXACT [EC:2.4.2.9]
synonym: "UMP:diphosphate phospho-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.9]
synonym: "UMP:pyrophosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.9]
synonym: "UPRTase activity" EXACT [EC:2.4.2.9]
synonym: "uridine 5'-phosphate pyrophosphorylase activity" EXACT [EC:2.4.2.9]
synonym: "uridine monophosphate pyrophosphorylase activity" EXACT [EC:2.4.2.9]
synonym: "uridylate pyrophosphorylase activity" EXACT [EC:2.4.2.9]
synonym: "uridylic pyrophosphorylase activity" EXACT [EC:2.4.2.9]
xref: EC:2.4.2.9
xref: KEGG:R00966
xref: MetaCyc:URACIL-PRIBOSYLTRANS-RXN
xref: RHEA:13020
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0004846
name: urate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: urate + O2 + H2O = 5-hydroxyisourate + hydrogen peroxide." [EC:1.7.3.3]
subset: gosubset_prok
synonym: "urate:oxygen oxidoreductase activity" EXACT [EC:1.7.3.3]
synonym: "uric acid oxidase activity" EXACT [EC:1.7.3.3]
synonym: "uricase activity" EXACT [EC:1.7.3.3]
synonym: "uricase II activity" NARROW [EC:1.7.3.3]
xref: EC:1.7.3.3
xref: MetaCyc:URATE-OXIDASE-RXN
xref: RHEA:21371
xref: UM-BBD_reactionID:r1322
is_a: GO:0016663 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor

[Term]
id: GO:0004847
name: urea carboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + bicarbonate + urea = ADP + 2 H(+) + phosphate + urea-1-carboxylate." [EC:6.3.4.6, RHEA:20899]
subset: gosubset_prok
synonym: "ATP--urea amidolyase activity" EXACT [EC:6.3.4.6]
synonym: "UALase activity" EXACT [EC:6.3.4.6]
synonym: "UCA activity" EXACT [EC:6.3.4.6]
synonym: "urea amidolyase activity" EXACT [EC:6.3.4.6]
synonym: "urea carboxylase (hydrolysing)" EXACT [EC:6.3.4.6]
synonym: "urea carboxylase (hydrolyzing) activity" EXACT [EC:6.3.4.6]
synonym: "urea:carbon-dioxide ligase (ADP-forming)" EXACT [EC:6.3.4.6]
synonym: "urease (ATP-hydrolysing)" EXACT [EC:6.3.4.6]
synonym: "urease (ATP-hydrolyzing) activity" EXACT [EC:6.3.4.6]
xref: EC:6.3.4.6
xref: KEGG:R00774
xref: MetaCyc:UREA-CARBOXYLASE-RXN
xref: RHEA:20899
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0004848
name: ureidoglycolate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-ureidoglycolate + H(2)O + 2 H(+) = CO(2) + glyoxylate + 2 NH(4)(+)." [EC:3.5.3.19, RHEA:19812]
comment: Take care to annotate to the reaction, not simply the enzyme name. The name "ureidoglycolate hydrolase" has variously been used to refer to two distinctly different enzymes. Both enzymes act on ureidoglycolate and produce glyoxylate, but the mechanism and reaction products are different. The "ureidoglycolate hydrolase" listed in the Enzyme commission (EC) is a ureidoglycolate amidohydrolase, releasing ammonia, (EC 3.5.3.19, GO:0004848). The "ureidoglycolate hydrolase" characterized in PMID:3915539 (published prior to the EC designation of EC 3.5.3.19) is a ureidoglycolate lyase, releasing urea (EC 4.3.2.3, GO:0050385). The inappropriate labelling of ureidoglycolate lyase as EC 3.5.3.19 has caused much confusion in the literature (see PMID:24107613). Take care to correctly annotate based on the reaction products, rather than name.
subset: gosubset_prok
synonym: "(S)-ureidoglycolate amidohydrolase (decarboxylating)" EXACT [EC:3.5.3.19]
xref: EC:3.5.3.19
xref: KEGG:R00469
xref: MetaCyc:UREIDOGLYCOLATE-HYDROLASE-RXN
xref: RHEA:19812
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0004849
name: uridine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + uridine = ADP + UMP." [EC:2.7.1.48]
subset: gosubset_prok
synonym: "ATP:uridine 5'-phosphotransferase activity" EXACT [EC:2.7.1.48]
synonym: "pyrimidine ribonucleoside kinase activity" EXACT [EC:2.7.1.48]
synonym: "uridine kinase (phosphorylating)" EXACT [EC:2.7.1.48]
synonym: "uridine kinase reaction" EXACT []
synonym: "uridine monophosphokinase activity" EXACT [EC:2.7.1.48]
synonym: "uridine phosphokinase activity" EXACT [EC:2.7.1.48]
synonym: "uridine-cytidine kinase activity" EXACT [EC:2.7.1.48]
xref: EC:2.7.1.48
xref: MetaCyc:URIDINEKIN-RXN
xref: RHEA:16828
is_a: GO:0019206 ! nucleoside kinase activity
relationship: part_of GO:0006222 ! UMP biosynthetic process

[Term]
id: GO:0004850
name: uridine phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: uridine + phosphate = uracil + alpha-D-ribose 1-phosphate." [EC:2.4.2.3]
subset: gosubset_prok
synonym: "pyrimidine phosphorylase activity" BROAD [EC:2.4.2.3]
synonym: "UPase activity" EXACT [EC:2.4.2.3]
synonym: "UPH" RELATED [EC:2.4.2.3]
synonym: "UrdPase activity" EXACT [EC:2.4.2.3]
synonym: "uridine:phosphate alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.3]
xref: EC:2.4.2.3
xref: MetaCyc:URPHOS-RXN
xref: Reactome:REACT_101041 "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate [UPP], Danio rerio"
xref: Reactome:REACT_101427 "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP], Sus scrofa"
xref: Reactome:REACT_103383 "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate [UPP], Rattus norvegicus"
xref: Reactome:REACT_109044 "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP], Xenopus tropicalis"
xref: Reactome:REACT_109074 "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate [UPP], Taeniopygia guttata"
xref: Reactome:REACT_109460 "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP], Mus musculus"
xref: Reactome:REACT_110273 "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP], Caenorhabditis elegans"
xref: Reactome:REACT_110888 "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate [UPP], Xenopus tropicalis"
xref: Reactome:REACT_1812 "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate [UPP], Homo sapiens"
xref: Reactome:REACT_2200 "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP], Homo sapiens"
xref: Reactome:REACT_30745 "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate [UPP], Canis familiaris"
xref: Reactome:REACT_32075 "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP], Drosophila melanogaster"
xref: Reactome:REACT_33167 "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP], Canis familiaris"
xref: Reactome:REACT_77223 "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate [UPP], Bos taurus"
xref: Reactome:REACT_84353 "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate [UPP], Sus scrofa"
xref: Reactome:REACT_88039 "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP], Bos taurus"
xref: Reactome:REACT_90697 "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate [UPP], Mus musculus"
xref: Reactome:REACT_91776 "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate [UPP], Drosophila melanogaster"
xref: Reactome:REACT_91985 "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP], Taeniopygia guttata"
xref: Reactome:REACT_94957 "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate [UPP], Gallus gallus"
xref: Reactome:REACT_99312 "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP], Danio rerio"
xref: Reactome:REACT_99510 "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP], Rattus norvegicus"
xref: Reactome:REACT_99604 "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate [UPP], Caenorhabditis elegans"
xref: Reactome:REACT_99702 "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP], Gallus gallus"
xref: RHEA:24391
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0004851
name: uroporphyrin-III C-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + uroporphyrin III = 2 S-adenosyl-L-homocysteine + precorrin-2." [EC:2.1.1.107]
subset: gosubset_prok
synonym: "adenosylmethionine-uroporphyrinogen III methyltransferase activity" EXACT [EC:2.1.1.107]
synonym: "CobA" RELATED [EC:2.1.1.107]
synonym: "CysG" RELATED [EC:2.1.1.107]
synonym: "S-adenosyl-L-methionine-dependent uroporphyrinogen III methylase activity" EXACT [EC:2.1.1.107]
synonym: "S-adenosyl-L-methionine:uroporphyrin-III C-methyltransferase activity" EXACT [EC:2.1.1.107]
synonym: "S-adenosyl-L-methionine:uroporphyrinogen-III C-methyltransferase activity" EXACT [EC:2.1.1.107]
synonym: "SirA" RELATED [EC:2.1.1.107]
synonym: "SUMT activity" EXACT [EC:2.1.1.107]
synonym: "urogen III methylase activity" EXACT [EC:2.1.1.107]
synonym: "uroporphyrinogen III methylase activity" EXACT [EC:2.1.1.107]
synonym: "uroporphyrinogen methyltransferase activity" EXACT [EC:2.1.1.107]
synonym: "uroporphyrinogen-III C-methyltransferase activity" EXACT [EC:2.1.1.107]
synonym: "uroporphyrinogen-III methylase activity" EXACT [EC:2.1.1.107]
synonym: "uroporphyrinogen-III methyltransferase activity" EXACT [EC:2.1.1.107]
xref: EC:2.1.1.107
xref: MetaCyc:UROPORIIIMETHYLTRANSA-RXN
is_a: GO:0008169 ! C-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0004852
name: uroporphyrinogen-III synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydroxymethylbilane = H(2)O + uroporphyrinogen III." [EC:4.2.1.75, RHEA:18968]
subset: gosubset_prok
synonym: "hydroxymethylbilane hydro-lyase (cyclizing) activity" EXACT [EC:4.2.1.75]
synonym: "hydroxymethylbilane hydro-lyase (cyclizing; uroporphyrinogen-III-forming)" EXACT [EC:4.2.1.75]
synonym: "porphobilinogenase activity" EXACT [EC:4.2.1.75]
synonym: "URO-synthase activity" EXACT [EC:4.2.1.75]
synonym: "uroporphyrinogen III cosynthase activity" EXACT [EC:4.2.1.75]
synonym: "uroporphyrinogen isomerase activity" EXACT [EC:4.2.1.75]
synonym: "uroporphyrinogen-III cosynthase activity" EXACT [EC:4.2.1.75]
synonym: "uroporphyrinogen-III cosynthetase activity" EXACT [EC:4.2.1.75]
xref: EC:4.2.1.75
xref: KEGG:R03165
xref: MetaCyc:UROGENIIISYN-RXN
xref: Reactome:REACT_102458 "Conversion of HMB to uroporphyrinogen III, Drosophila melanogaster"
xref: Reactome:REACT_102627 "Conversion of HMB to uroporphyrinogen III, Sus scrofa"
xref: Reactome:REACT_104364 "Conversion of HMB to uroporphyrinogen III, Canis familiaris"
xref: Reactome:REACT_104957 "Conversion of HMB to uroporphyrinogen III, Rattus norvegicus"
xref: Reactome:REACT_116029 "hydroxymethylbilane => uroporphyrinogen III + H2O, Gallus gallus"
xref: Reactome:REACT_28073 "Conversion of HMB to uroporphyrinogen III, Bos taurus"
xref: Reactome:REACT_33499 "Conversion of HMB to uroporphyrinogen III, Gallus gallus"
xref: Reactome:REACT_77260 "Conversion of HMB to uroporphyrinogen III, Saccharomyces cerevisiae"
xref: Reactome:REACT_81186 "Conversion of HMB to uroporphyrinogen III, Schizosaccharomyces pombe"
xref: Reactome:REACT_82801 "Conversion of HMB to uroporphyrinogen III, Mus musculus"
xref: Reactome:REACT_84413 "Conversion of HMB to uroporphyrinogen III, Xenopus tropicalis"
xref: Reactome:REACT_92101 "Conversion of HMB to uroporphyrinogen III, Taeniopygia guttata"
xref: Reactome:REACT_9526 "Conversion of HMB to uroporphyrinogen III, Homo sapiens"
xref: Reactome:REACT_99974 "Conversion of HMB to uroporphyrinogen III, Danio rerio"
xref: RHEA:18968
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0004853
name: uroporphyrinogen decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: uroporphyrinogen-III = coproporphyrinogen + 4 CO2." [EC:4.1.1.37]
subset: gosubset_prok
synonym: "porphyrinogen carboxy-lyase activity" EXACT [EC:4.1.1.37]
synonym: "porphyrinogen decarboxylase activity" EXACT [EC:4.1.1.37]
synonym: "uroporphyrinogen III decarboxylase activity" EXACT [EC:4.1.1.37]
synonym: "uroporphyrinogen-III carboxy-lyase (coproporphyrinogen-III-forming)" EXACT [EC:4.1.1.37]
synonym: "uroporphyrinogen-III carboxy-lyase activity" EXACT [EC:4.1.1.37]
xref: EC:4.1.1.37
xref: MetaCyc:UROGENDECARBOX-RXN
xref: Reactome:REACT_103588 "Uroporphyrinogen I is decarboxylated to form coproporphyrinogen I, Plasmodium falciparum"
xref: Reactome:REACT_103747 "Uroporphyrinogen III is decarboxylated to form coproporphyrinogen III, Saccharomyces cerevisiae"
xref: Reactome:REACT_104505 "Uroporphyrinogen I is decarboxylated to form coproporphyrinogen I, Danio rerio"
xref: Reactome:REACT_104610 "Uroporphyrinogen I is decarboxylated to form coproporphyrinogen I, Canis familiaris"
xref: Reactome:REACT_105404 "Uroporphyrinogen III is decarboxylated to form coproporphyrinogen III, Staphylococcus aureus N315"
xref: Reactome:REACT_106469 "Uroporphyrinogen I is decarboxylated to form coproporphyrinogen I, Mycobacterium tuberculosis"
xref: Reactome:REACT_106757 "Uroporphyrinogen III is decarboxylated to form coproporphyrinogen III, Escherichia coli"
xref: Reactome:REACT_108603 "Uroporphyrinogen I is decarboxylated to form coproporphyrinogen I, Mus musculus"
xref: Reactome:REACT_109189 "Uroporphyrinogen III is decarboxylated to form coproporphyrinogen III, Mus musculus"
xref: Reactome:REACT_110049 "Uroporphyrinogen III is decarboxylated to form coproporphyrinogen III, Sus scrofa"
xref: Reactome:REACT_110571 "Uroporphyrinogen III is decarboxylated to form coproporphyrinogen III, Schizosaccharomyces pombe"
xref: Reactome:REACT_115726 "uroporphyrinogen III => coproporphyrinogen III + 4 CO2, Gallus gallus"
xref: Reactome:REACT_116160 "uroporphyrinogen I => coproporphyrinogen I + 4 CO2, Gallus gallus"
xref: Reactome:REACT_30846 "Uroporphyrinogen I is decarboxylated to form coproporphyrinogen I, Xenopus tropicalis"
xref: Reactome:REACT_31736 "Uroporphyrinogen I is decarboxylated to form coproporphyrinogen I, Gallus gallus"
xref: Reactome:REACT_77233 "Uroporphyrinogen I is decarboxylated to form coproporphyrinogen I, Drosophila melanogaster"
xref: Reactome:REACT_77869 "Uroporphyrinogen III is decarboxylated to form coproporphyrinogen III, Rattus norvegicus"
xref: Reactome:REACT_77882 "Uroporphyrinogen III is decarboxylated to form coproporphyrinogen III, Xenopus tropicalis"
xref: Reactome:REACT_78941 "Uroporphyrinogen III is decarboxylated to form coproporphyrinogen III, Canis familiaris"
xref: Reactome:REACT_79879 "Uroporphyrinogen I is decarboxylated to form coproporphyrinogen I, Rattus norvegicus"
xref: Reactome:REACT_81296 "Uroporphyrinogen I is decarboxylated to form coproporphyrinogen I, Saccharomyces cerevisiae"
xref: Reactome:REACT_81420 "Uroporphyrinogen I is decarboxylated to form coproporphyrinogen I, Dictyostelium discoideum"
xref: Reactome:REACT_81562 "Uroporphyrinogen III is decarboxylated to form coproporphyrinogen III, Taeniopygia guttata"
xref: Reactome:REACT_82213 "Uroporphyrinogen III is decarboxylated to form coproporphyrinogen III, Bos taurus"
xref: Reactome:REACT_83091 "Uroporphyrinogen III is decarboxylated to form coproporphyrinogen III, Danio rerio"
xref: Reactome:REACT_84852 "Uroporphyrinogen III is decarboxylated to form coproporphyrinogen III, Dictyostelium discoideum"
xref: Reactome:REACT_85097 "Uroporphyrinogen III is decarboxylated to form coproporphyrinogen III, Gallus gallus"
xref: Reactome:REACT_85682 "Uroporphyrinogen III is decarboxylated to form coproporphyrinogen III, Mycobacterium tuberculosis"
xref: Reactome:REACT_85719 "Uroporphyrinogen I is decarboxylated to form coproporphyrinogen I, Schizosaccharomyces pombe"
xref: Reactome:REACT_88601 "Uroporphyrinogen I is decarboxylated to form coproporphyrinogen I, Taeniopygia guttata"
xref: Reactome:REACT_89025 "Uroporphyrinogen I is decarboxylated to form coproporphyrinogen I, Staphylococcus aureus N315"
xref: Reactome:REACT_92352 "Uroporphyrinogen I is decarboxylated to form coproporphyrinogen I, Bos taurus"
xref: Reactome:REACT_93060 "Uroporphyrinogen I is decarboxylated to form coproporphyrinogen I, Escherichia coli"
xref: Reactome:REACT_9422 "Uroporphyrinogen III is decarboxylated to form coproporphyrinogen III, Homo sapiens"
xref: Reactome:REACT_9436 "Uroporphyrinogen I is decarboxylated to form coproporphyrinogen I, Homo sapiens"
xref: Reactome:REACT_94767 "Uroporphyrinogen I is decarboxylated to form coproporphyrinogen I, Sus scrofa"
xref: Reactome:REACT_97602 "Uroporphyrinogen III is decarboxylated to form coproporphyrinogen III, Plasmodium falciparum"
xref: Reactome:REACT_98416 "Uroporphyrinogen III is decarboxylated to form coproporphyrinogen III, Drosophila melanogaster"
xref: RHEA:19868
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004854
name: xanthine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: xanthine + NAD+ + H2O = urate + NADH + H+." [EC:1.17.1.4]
subset: gosubset_prok
synonym: "NAD-xanthine dehydrogenase activity" EXACT [EC:1.17.1.4]
synonym: "xanthine oxidoreductase activity" BROAD [EC:1.17.1.4]
synonym: "xanthine-NAD oxidoreductase activity" EXACT [EC:1.17.1.4]
synonym: "xanthine/NAD(+) oxidoreductase activity" EXACT [EC:1.17.1.4]
synonym: "xanthine/NAD+ oxidoreductase activity" EXACT [EC:1.17.1.4]
synonym: "xanthine:NAD+ oxidoreductase activity" EXACT [EC:1.17.1.4]
xref: EC:1.17.1.4
xref: MetaCyc:RXN0-901
xref: Reactome:REACT_116028 "xanthine + H2O + NAD+ => urate + NADH + H+, Gallus gallus"
is_a: GO:0016726 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor

[Term]
id: GO:0004855
name: xanthine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: xanthine + H2O + O2 = urate + hydrogen peroxide." [EC:1.17.3.2]
subset: gosubset_prok
synonym: "hypoxanthine-xanthine oxidase activity" BROAD [EC:1.17.3.2]
synonym: "schardinger enzyme" RELATED [EC:1.17.3.2]
synonym: "Schardinger enzyme activity" RELATED [EC:1.17.3.2]
synonym: "xanthine oxidoreductase activity" BROAD [EC:1.17.3.2]
synonym: "xanthine:O(2) oxidoreductase activity" EXACT [EC:1.17.3.2]
synonym: "xanthine:O2 oxidoreductase activity" EXACT [EC:1.17.3.2]
synonym: "xanthine:oxygen oxidoreductase activity" EXACT [EC:1.17.3.2]
synonym: "xanthine:xanthine oxidase activity" EXACT [EC:1.17.3.2]
xref: EC:1.17.3.2
xref: MetaCyc:XANTHINE-OXIDASE-RXN
xref: Reactome:REACT_101220 "Xanthine + H2O + O2 => Urate + H2O2, Arabidopsis thaliana"
xref: Reactome:REACT_103198 "Hypoxanthine + H2O + O2 => Xanthine + H2O2, Rattus norvegicus"
xref: Reactome:REACT_104232 "Xanthine + H2O + O2 => Urate + H2O2, Canis familiaris"
xref: Reactome:REACT_104374 "Xanthine + H2O + O2 => Urate + H2O2, Oryza sativa"
xref: Reactome:REACT_105088 "Xanthine + H2O + O2 => Urate + H2O2, Mus musculus"
xref: Reactome:REACT_113063 "Hypoxanthine + H2O + O2 => Xanthine + H2O2, Escherichia coli"
xref: Reactome:REACT_113246 "Xanthine + H2O + O2 => Urate + H2O2, Escherichia coli"
xref: Reactome:REACT_113574 "Xanthine + H2O + O2 => Urate + H2O2, Mycobacterium tuberculosis"
xref: Reactome:REACT_114235 "Hypoxanthine + H2O + O2 => Xanthine + H2O2, Dictyostelium discoideum"
xref: Reactome:REACT_114723 "Xanthine + H2O + O2 => Urate + H2O2, Dictyostelium discoideum"
xref: Reactome:REACT_115203 "Hypoxanthine + H2O + O2 => Xanthine + H2O2, Mycobacterium tuberculosis"
xref: Reactome:REACT_29610 "Hypoxanthine + H2O + O2 => Xanthine + H2O2, Oryza sativa"
xref: Reactome:REACT_32882 "Xanthine + H2O + O2 => Urate + H2O2, Rattus norvegicus"
xref: Reactome:REACT_33683 "Hypoxanthine + H2O + O2 => Xanthine + H2O2, Sus scrofa"
xref: Reactome:REACT_34162 "Xanthine + H2O + O2 => Urate + H2O2, Taeniopygia guttata"
xref: Reactome:REACT_401 "Hypoxanthine + H2O + O2 => Xanthine + H2O2, Homo sapiens"
xref: Reactome:REACT_624 "Xanthine + H2O + O2 => Urate + H2O2, Homo sapiens"
xref: Reactome:REACT_78184 "Hypoxanthine + H2O + O2 => Xanthine + H2O2, Arabidopsis thaliana"
xref: Reactome:REACT_78983 "Hypoxanthine + H2O + O2 => Xanthine + H2O2, Danio rerio"
xref: Reactome:REACT_79038 "Xanthine + H2O + O2 => Urate + H2O2, Danio rerio"
xref: Reactome:REACT_83465 "Hypoxanthine + H2O + O2 => Xanthine + H2O2, Mus musculus"
xref: Reactome:REACT_83556 "Hypoxanthine + H2O + O2 => Xanthine + H2O2, Xenopus tropicalis"
xref: Reactome:REACT_83908 "Hypoxanthine + H2O + O2 => Xanthine + H2O2, Bos taurus"
xref: Reactome:REACT_84414 "Hypoxanthine + H2O + O2 => Xanthine + H2O2, Canis familiaris"
xref: Reactome:REACT_86820 "Hypoxanthine + H2O + O2 => Xanthine + H2O2, Gallus gallus"
xref: Reactome:REACT_87777 "Xanthine + H2O + O2 => Urate + H2O2, Bos taurus"
xref: Reactome:REACT_89451 "Xanthine + H2O + O2 => Urate + H2O2, Sus scrofa"
xref: Reactome:REACT_91142 "Xanthine + H2O + O2 => Urate + H2O2, Gallus gallus"
xref: Reactome:REACT_93758 "Xanthine + H2O + O2 => Urate + H2O2, Xenopus tropicalis"
xref: Reactome:REACT_98626 "Hypoxanthine + H2O + O2 => Xanthine + H2O2, Taeniopygia guttata"
xref: RHEA:21135
xref: UM-BBD_enzymeID:e0781
is_a: GO:0016727 ! oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor

[Term]
id: GO:0004856
name: xylulokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-xylulose + ATP = D-xylulose 5-phosphate + ADP + 2 H(+)." [EC:2.7.1.17, RHEA:10967]
subset: gosubset_prok
synonym: "ATP:D-xylulose 5-phosphotransferase activity" EXACT [EC:2.7.1.17]
synonym: "D-xylulokinase activity" EXACT [EC:2.7.1.17]
synonym: "xylulokinase (phosphorylating)" EXACT [EC:2.7.1.17]
synonym: "xylulose kinase activity" EXACT [EC:2.7.1.17]
xref: EC:2.7.1.17
xref: KEGG:R01639
xref: MetaCyc:XYLULOKIN-RXN
xref: RHEA:10967
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0004857
name: enzyme inhibitor activity
namespace: molecular_function
alt_id: GO:0048551
def: "Binds to and stops, prevents or reduces the activity of an enzyme." [GOC:ai, GOC:ebc]
subset: gosubset_prok
synonym: "metalloenzyme inhibitor activity" NARROW []
is_a: GO:0030234 ! enzyme regulator activity
relationship: part_of GO:0043086 ! negative regulation of catalytic activity

[Term]
id: GO:0004858
name: dUTP pyrophosphatase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of dUTP pyrophosphatase." [GOC:mah]
is_a: GO:0004857 ! enzyme inhibitor activity
relationship: negatively_regulates GO:0004170 ! dUTP diphosphatase activity

[Term]
id: GO:0004859
name: phospholipase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a phospholipid." [GOC:ai, GOC:rl]
is_a: GO:0055102 ! lipase inhibitor activity
relationship: negatively_regulates GO:0004620 ! phospholipase activity

[Term]
id: GO:0004860
name: protein kinase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai]
subset: gosubset_prok
is_a: GO:0019210 ! kinase inhibitor activity
is_a: GO:0019887 ! protein kinase regulator activity
relationship: negatively_regulates GO:0004672 ! protein kinase activity
relationship: part_of GO:0006469 ! negative regulation of protein kinase activity

[Term]
id: GO:0004861
name: cyclin-dependent protein serine/threonine kinase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a cyclin-dependent protein serine/threonine kinase." [GOC:mah, GOC:pr]
synonym: "CDK inhibitor" RELATED []
synonym: "cyclin dependent kinase inhibitor" RELATED []
synonym: "cyclin dependent protein kinase inhibitor activity" EXACT []
synonym: "cyclin-dependent kinase inhibitor" RELATED []
synonym: "cyclin-dependent protein kinase inhibitor activity" BROAD []
xref: Reactome:REACT_100417 "Inactivation of Cyclin E:Cdk2 complexes by p27/p21, Rattus norvegicus"
xref: Reactome:REACT_104575 "Inactivation of Cyclin E:Cdk2 complexes by p27/p21, Sus scrofa"
xref: Reactome:REACT_28355 "Inactivation of Cyclin E:Cdk2 complexes by p27/p21, Canis familiaris"
xref: Reactome:REACT_334 "Inactivation of Cyclin E:Cdk2 complexes by p27/p21, Homo sapiens"
xref: Reactome:REACT_50478 "Inactivation of Cyclin A:Cdk2 complexes by p27/p21, Canis familiaris"
xref: Reactome:REACT_81585 "Inactivation of Cyclin E:Cdk2 complexes by p27/p21, Mus musculus"
xref: Reactome:REACT_87115 "Inactivation of Cyclin A:Cdk2 complexes by p27/p21, Danio rerio"
xref: Reactome:REACT_89720 "Inactivation of Cyclin A:Cdk2 complexes by p27/p21, Xenopus tropicalis"
xref: Reactome:REACT_9005 "Inactivation of Cyclin A:Cdk2 complexes by p27/p21, Homo sapiens"
xref: Reactome:REACT_92594 "Inactivation of Cyclin E:Cdk2 complexes by p27/p21, Bos taurus"
xref: Reactome:REACT_93279 "Inactivation of Cyclin A:Cdk2 complexes by p27/p21, Sus scrofa"
xref: Reactome:REACT_93652 "Inactivation of Cyclin E:Cdk2 complexes by p27/p21, Xenopus tropicalis"
xref: Reactome:REACT_94178 "Inactivation of Cyclin E:Cdk2 complexes by p27/p21, Danio rerio"
xref: Reactome:REACT_94477 "Inactivation of Cyclin A:Cdk2 complexes by p27/p21, Bos taurus"
xref: Reactome:REACT_95674 "Inactivation of Cyclin A:Cdk2 complexes by p27/p21, Rattus norvegicus"
xref: Reactome:REACT_97462 "Inactivation of Cyclin A:Cdk2 complexes by p27/p21, Mus musculus"
is_a: GO:0016538 ! cyclin-dependent protein serine/threonine kinase regulator activity
is_a: GO:0030291 ! protein serine/threonine kinase inhibitor activity
relationship: negatively_regulates GO:0004693 ! cyclin-dependent protein serine/threonine kinase activity

[Term]
id: GO:0004862
name: cAMP-dependent protein kinase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a cAMP-dependent protein kinase." [GOC:mah]
xref: Reactome:REACT_100418 "DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function, Canis familiaris"
xref: Reactome:REACT_114726 "DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function, Xenopus tropicalis"
xref: Reactome:REACT_15540 "DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function, Homo sapiens"
xref: Reactome:REACT_29311 "DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function, Danio rerio"
xref: Reactome:REACT_31939 "DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function, Mus musculus"
xref: Reactome:REACT_78250 "DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function, Bos taurus"
xref: Reactome:REACT_81482 "DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function, Sus scrofa"
xref: Reactome:REACT_96175 "DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function, Rattus norvegicus"
is_a: GO:0030291 ! protein serine/threonine kinase inhibitor activity
relationship: negatively_regulates GO:0004691 ! cAMP-dependent protein kinase activity

[Term]
id: GO:0004864
name: protein phosphatase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a protein phosphatase, an enzyme that hydrolyzes phosphate groups from phosphorylated proteins." [GOC:ai]
synonym: "phosphoprotein phosphatase inhibitor activity" EXACT [GOC:curators]
is_a: GO:0019212 ! phosphatase inhibitor activity
is_a: GO:0019888 ! protein phosphatase regulator activity
relationship: negatively_regulates GO:0004721 ! phosphoprotein phosphatase activity

[Term]
id: GO:0004865
name: protein serine/threonine phosphatase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a serine/threonine protein phosphatase, an enzyme that catalyzes the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate." [GOC:dph, GOC:tb]
is_a: GO:0004864 ! protein phosphatase inhibitor activity

[Term]
id: GO:0004866
name: endopeptidase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides." [GOC:jl]
subset: gosubset_prok
synonym: "alpha-2 macroglobulin" RELATED []
synonym: "endoproteinase inhibitor" NARROW []
synonym: "proteinase inhibitor" NARROW []
is_a: GO:0030414 ! peptidase inhibitor activity
is_a: GO:0061135 ! endopeptidase regulator activity
relationship: negatively_regulates GO:0004175 ! endopeptidase activity
relationship: part_of GO:0010951 ! negative regulation of endopeptidase activity

[Term]
id: GO:0004867
name: serine-type endopeptidase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai]
subset: gosubset_prok
synonym: "serine protease inhibitor activity" NARROW []
synonym: "serine proteinase inhibitor activity" NARROW []
synonym: "serpin activity" NARROW []
xref: Reactome:REACT_104050 "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin, Rattus norvegicus"
xref: Reactome:REACT_104247 "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR, Rattus norvegicus"
xref: Reactome:REACT_104475 "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1, Danio rerio"
xref: Reactome:REACT_104528 "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR, Rattus norvegicus"
xref: Reactome:REACT_105611 "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR, Bos taurus"
xref: Reactome:REACT_106048 "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR, Canis familiaris"
xref: Reactome:REACT_106218 "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin, Sus scrofa"
xref: Reactome:REACT_106511 "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR, Mus musculus"
xref: Reactome:REACT_107595 "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1, Xenopus tropicalis"
xref: Reactome:REACT_109088 "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR, Bos taurus"
xref: Reactome:REACT_113222 "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin, Xenopus tropicalis"
xref: Reactome:REACT_142 "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR, Homo sapiens"
xref: Reactome:REACT_221 "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin, Homo sapiens"
xref: Reactome:REACT_28910 "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1, Rattus norvegicus"
xref: Reactome:REACT_30137 "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1, Mus musculus"
xref: Reactome:REACT_32135 "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1, Rattus norvegicus"
xref: Reactome:REACT_427 "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1, Homo sapiens"
xref: Reactome:REACT_747 "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1, Homo sapiens"
xref: Reactome:REACT_78671 "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1, Xenopus tropicalis"
xref: Reactome:REACT_80821 "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin, Gallus gallus"
xref: Reactome:REACT_83326 "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin, Mus musculus"
xref: Reactome:REACT_83397 "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR, Sus scrofa"
xref: Reactome:REACT_83721 "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR, Danio rerio"
xref: Reactome:REACT_863 "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR, Homo sapiens"
xref: Reactome:REACT_86945 "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1, Bos taurus"
xref: Reactome:REACT_88697 "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1, Canis familiaris"
xref: Reactome:REACT_89535 "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin, Taeniopygia guttata"
xref: Reactome:REACT_90524 "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1, Bos taurus"
xref: Reactome:REACT_91079 "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1, Canis familiaris"
xref: Reactome:REACT_91370 "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin, Danio rerio"
xref: Reactome:REACT_92292 "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR, Canis familiaris"
xref: Reactome:REACT_93959 "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin, Canis familiaris"
xref: Reactome:REACT_94815 "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin, Bos taurus"
xref: Reactome:REACT_96330 "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR, Mus musculus"
xref: Reactome:REACT_97070 "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1, Mus musculus"
xref: Reactome:REACT_99122 "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1, Danio rerio"
is_a: GO:0004866 ! endopeptidase inhibitor activity
relationship: negatively_regulates GO:0004252 ! serine-type endopeptidase activity

[Term]
id: GO:0004868
name: obsolete serpin
namespace: molecular_function
def: "OBSOLETE. A superfamily of proteins, many of which inhibit serine proteinases and exhibit a high degree of homology with classical serine proteinase inhibitors such as alpha1-antitrypsin or antithrombin." [GOC:ai, ISBN:0198506732]
comment: This term was made obsolete because it represents a class of gene products.
synonym: "serpin" EXACT []
is_obsolete: true
consider: GO:0004867

[Term]
id: GO:0004869
name: cysteine-type endopeptidase inhibitor activity
namespace: molecular_function
alt_id: GO:0004870
def: "Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:dph, GOC:tb]
subset: gosubset_prok
synonym: "cysteine protease inhibitor activity" NARROW [GOC:dph, GOC:tb]
synonym: "thiol protease inhibitor" NARROW []
is_a: GO:0004866 ! endopeptidase inhibitor activity
relationship: negatively_regulates GO:0008234 ! cysteine-type peptidase activity

[Term]
id: GO:0004871
name: signal transducer activity
namespace: molecular_function
alt_id: GO:0005062
alt_id: GO:0009369
alt_id: GO:0009370
def: "Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
comment: Ligands do NOT have the molecular function 'signal transducer activity'.
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity" NARROW []
synonym: "quorum sensing response regulator activity" NARROW []
synonym: "quorum sensing signal generator activity" NARROW []
is_a: GO:0003674 ! molecular_function
intersection_of: GO:0003674 ! molecular_function
intersection_of: part_of GO:0007165 ! signal transduction
relationship: part_of GO:0007165 ! signal transduction

[Term]
id: GO:0004872
name: receptor activity
namespace: molecular_function
alt_id: GO:0019041
def: "Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732]
subset: goslim_chembl
subset: goslim_metagenomics
subset: goslim_plant
subset: gosubset_prok
synonym: "receptor guanylate cyclase activity" NARROW []
synonym: "viral antireceptor activity" NARROW []
is_a: GO:0060089 ! molecular transducer activity

[Term]
id: GO:0004873
name: asialoglycoprotein receptor activity
namespace: molecular_function
def: "Receiving an asialoglycoprotein, and delivering the asialoglycoprotein into the cell via endocytosis. An asialoglycoprotein is a plasma glycoproteins from which the terminal sialic acid residue on their complex carbohydrate groups has been removed. The asialoglycoprotein receptor recognizes the terminal galactose and N-acetylgalactosamine units of the asialoglycoprotein, the receptor-ligand complex is internalized and transported to a sorting organelle where disassociation occurs before the receptor is recycled to the cell membrane." [GOC:bf, PMID:11278827, PMID:7624395, Wikipedia:Asialoglycoprotein]
subset: goslim_chembl
is_a: GO:0038024 ! cargo receptor activity

[Term]
id: GO:0004874
name: aryl hydrocarbon receptor activity
namespace: molecular_function
def: "Combining with an aryl hydrocarbon and transmitting the signal to initiate a change in cell activity. The aryl hydrocarbon receptor is a ligand-activated transcription factor which translocates to the nucleus to activate transcription upon ligand-binding." [GOC:ai, GOC:signaling, PMID:1325649, PMID:7493958]
is_a: GO:0038023 ! signaling receptor activity
relationship: part_of GO:0030522 ! intracellular receptor signaling pathway

[Term]
id: GO:0004875
name: complement receptor activity
namespace: molecular_function
def: "Combining with any component or product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149, PMID:11884446]
comment: Note that the complement cascade includes all of the components involved in the classical complement pathway, the alternative complement pathway, and the lectin complement pathway, as well as the common components of all three pathways.
is_a: GO:0004888 ! transmembrane signaling receptor activity
relationship: has_part GO:0001848 ! complement binding
relationship: part_of GO:0002430 ! complement receptor mediated signaling pathway

[Term]
id: GO:0004876
name: complement component C3a receptor activity
namespace: molecular_function
def: "Combining with the C3a product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]
is_a: GO:0004875 ! complement receptor activity

[Term]
id: GO:0004877
name: complement component C3b receptor activity
namespace: molecular_function
def: "Combining with the C3b product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]
is_a: GO:0001847 ! opsonin receptor activity
is_a: GO:0004875 ! complement receptor activity
relationship: has_part GO:0001850 ! complement component C3a binding
relationship: has_part GO:0001851 ! complement component C3b binding

[Term]
id: GO:0004878
name: complement component C5a receptor activity
namespace: molecular_function
def: "Combining with the C5a product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]
is_a: GO:0001847 ! opsonin receptor activity
is_a: GO:0004875 ! complement receptor activity
relationship: has_part GO:0001856 ! complement component C5a binding
relationship: part_of GO:0038178 ! complement component C5a signaling pathway

[Term]
id: GO:0004879
name: RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
namespace: molecular_function
def: "Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II." [GOC:signaling, GOC:txnOH]
comment: GO:0004879 is intended for annotation of nuclear receptors that regulate transcription by binding directly to DNA. When the nuclear receptor functions by binding to other transcription factors or transcription factor complexes, consider instead annotating to 'ligand-activated RNA polymerase II transcription factor binding transcription factor activity ; GO:0038049'.
synonym: "ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity" EXACT []
synonym: "ligand-dependent nuclear receptor activity" RELATED [GOC:bf]
synonym: "ligand-dependent transcription factor activity" RELATED [GOC:bf]
synonym: "nuclear hormone receptor" NARROW []
synonym: "nuclear receptor activity" RELATED [GOC:bf]
is_a: GO:0000981 ! RNA polymerase II transcription factor activity, sequence-specific DNA binding
is_a: GO:0004871 ! signal transducer activity
is_a: GO:0098531 ! transcription factor activity, direct ligand regulated sequence-specific DNA binding
relationship: part_of GO:0030522 ! intracellular receptor signaling pathway

[Term]
id: GO:0004880
name: juvenile hormone receptor activity
namespace: molecular_function
def: "Combining with juvenile hormone and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II." [GOC:signaling, PMID:15475158]
is_a: GO:0004879 ! RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
is_a: GO:0038023 ! signaling receptor activity
relationship: has_part GO:0005500 ! juvenile hormone binding
relationship: part_of GO:0035626 ! juvenile hormone mediated signaling pathway

[Term]
id: GO:0004882
name: androgen receptor activity
namespace: molecular_function
def: "Combining with an androgen and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with an androgen response element in DNA in order to modulate transcription by RNA polymerase II." [GOC:signaling, PMID:19372015]
synonym: "androgen response element binding" NARROW [GOC:yaf]
is_a: GO:0003707 ! steroid hormone receptor activity
is_a: GO:0004879 ! RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
relationship: has_part GO:0005497 ! androgen binding
relationship: part_of GO:0030521 ! androgen receptor signaling pathway

[Term]
id: GO:0004883
name: glucocorticoid receptor activity
namespace: molecular_function
def: "Combining with a glucocorticoid and transmitting the signal within the cell trigger a change in cell activity or function." [GOC:signaling, PMID:17689856, PMID:20920967]
comment: If the mechanism by which a glucocorticoid receptor functions is known, consider instead annotating to the child terms 'glucocorticoid-activated sequence-specific DNA binding RNA polymerase II transcription factor activity ; GO:0038050' or 'glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity ; GO:0038051'.
is_a: GO:0003707 ! steroid hormone receptor activity
relationship: part_of GO:0042921 ! glucocorticoid receptor signaling pathway
relationship: part_of GO:0043402 ! glucocorticoid mediated signaling pathway

[Term]
id: GO:0004884
name: ecdysteroid hormone receptor activity
namespace: molecular_function
def: "Combining with an ecdysteroid hormone and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II." [GOC:signaling, PMID:1653701]
is_a: GO:0003707 ! steroid hormone receptor activity
is_a: GO:0004879 ! RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
relationship: part_of GO:0035076 ! ecdysone receptor-mediated signaling pathway

[Term]
id: GO:0004886
name: 9-cis retinoic acid receptor activity
namespace: molecular_function
def: "Combining with 9-cis retinoic acid and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II." [GOC:signaling, PMID:17132853]
synonym: "retinoid-X receptor activity" EXACT [GOC:bf]
synonym: "RXR" EXACT []
is_a: GO:0003708 ! retinoic acid receptor activity

[Term]
id: GO:0004887
name: thyroid hormone receptor activity
namespace: molecular_function
def: "Combining with thyroid hormone and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II." [GOC:signaling]
is_a: GO:0004879 ! RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
is_a: GO:0038023 ! signaling receptor activity
relationship: has_part GO:0070324 ! thyroid hormone binding

[Term]
id: GO:0004888
name: transmembrane signaling receptor activity
namespace: molecular_function
alt_id: GO:0004926
def: "Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]
comment: The definition allows for intracellular ligands for cases of transmission across an intracellular membrane, e.g. IP3 triggered release of Ca2+ from intracellular stores.
subset: gosubset_prok
synonym: "non G protein coupled 7TM receptor activity" NARROW []
synonym: "non-G-protein coupled 7TM receptor activity" NARROW []
synonym: "non-G-protein-coupled 7TM receptor activity" NARROW []
synonym: "transmembrane receptor activity" BROAD [GOC:bf, GOC:signaling]
synonym: "transmembrane signalling receptor activity" EXACT [GOC:mah]
is_a: GO:0038023 ! signaling receptor activity
is_a: GO:0099600 ! transmembrane receptor activity
intersection_of: GO:0099600 ! transmembrane receptor activity
intersection_of: part_of GO:0007165 ! signal transduction
relationship: part_of GO:0007165 ! signal transduction

[Term]
id: GO:0004889
name: acetylcholine-activated cation-selective channel activity
namespace: molecular_function
alt_id: GO:0016904
def: "Enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine." [GOC:mah, PMID:2466967]
synonym: "nicotinic acetylcholine-activated cation-selective channel activity" EXACT [GOC:bf]
is_a: GO:0005231 ! excitatory extracellular ligand-gated ion channel activity
is_a: GO:0005261 ! cation channel activity

[Term]
id: GO:0004890
name: GABA-A receptor activity
namespace: molecular_function
def: "Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels." [PMID:8974333]
comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'chloride channel activity ; GO:0005254' and 'inhibitory extracellular ligand-gated ion channel activity ; GO:0005237'.
synonym: "ionotropic GABA receptor activity" EXACT [GOC:bf]
is_a: GO:0016917 ! GABA receptor activity

[Term]
id: GO:0004892
name: obsolete B cell receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it describes the receptor type, and not an activity.
synonym: "B cell receptor activity" EXACT []
is_obsolete: true
consider: GO:0003823

[Term]
id: GO:0004894
name: obsolete T cell receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it describes a receptor type, and not an activity.
synonym: "T cell receptor activity" EXACT []
is_obsolete: true
consider: GO:0032394
consider: GO:0032395
consider: GO:0042605

[Term]
id: GO:0004895
name: obsolete cell adhesion receptor activity
namespace: molecular_function
def: "OBSOLETE. Combining with cell adhesion molecules to initiate a change in cell activity." [GOC:ai]
comment: This term was made obsolete because it represents gene products involved in the biological process of cell adhesion.
synonym: "cell adhesion receptor activity" EXACT []
is_obsolete: true
consider: GO:0005102
consider: GO:0005515
consider: GO:0007155
consider: GO:0016021
consider: GO:0030246
consider: GO:0050839

[Term]
id: GO:0004896
name: cytokine receptor activity
namespace: molecular_function
alt_id: GO:0004907
def: "Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:mah]
synonym: "hematopoietin/interferon-class (D200-domain) cytokine receptor activity" RELATED []
synonym: "IL receptor" NARROW []
synonym: "interleukin receptor activity" NARROW []
is_a: GO:0004888 ! transmembrane signaling receptor activity
relationship: has_part GO:0019955 ! cytokine binding
relationship: part_of GO:0019221 ! cytokine-mediated signaling pathway

[Term]
id: GO:0004897
name: ciliary neurotrophic factor receptor activity
namespace: molecular_function
def: "Combining with ciliary neurotrophic factor (CNTF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling]
synonym: "CNTF receptor activity" EXACT [GOC:mah]
synonym: "gp130" RELATED []
is_a: GO:0004896 ! cytokine receptor activity
relationship: has_part GO:0070119 ! ciliary neurotrophic factor binding
relationship: part_of GO:0070120 ! ciliary neurotrophic factor-mediated signaling pathway

[Term]
id: GO:0004898
name: obsolete gp130
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a gene product.
synonym: "gp130" EXACT []
is_obsolete: true
consider: GO:0004871
consider: GO:0004897
consider: GO:0004915
consider: GO:0004921

[Term]
id: GO:0004900
name: erythropoietin receptor activity
namespace: molecular_function
def: "Combining with erythropoietin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:ai, GOC:signaling]
is_a: GO:0004896 ! cytokine receptor activity
relationship: part_of GO:0038162 ! erythropoietin-mediated signaling pathway

[Term]
id: GO:0004901
name: granulocyte macrophage colony-stimulating factor receptor activity
namespace: molecular_function
alt_id: GO:0030525
def: "Combining with granulocyte macrophage colony-stimulating factor (GM-CSF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling]
synonym: "CSF-2 receptor activity" EXACT [GOC:bf]
synonym: "CSF2R" RELATED [GOC:bf]
synonym: "GM-CSF receptor activity" EXACT []
synonym: "GMC-SF receptor activity" EXACT []
synonym: "granulocyte macrophage colony stimulating factor receptor activity" EXACT []
is_a: GO:0004896 ! cytokine receptor activity
relationship: has_part GO:0042021 ! granulocyte macrophage colony-stimulating factor complex binding
relationship: part_of GO:0038157 ! granulocyte-macrophage colony-stimulating factor signaling pathway

[Term]
id: GO:0004902
name: granulocyte colony-stimulating factor receptor activity
namespace: molecular_function
alt_id: GO:0030524
def: "Combining with granulocyte colony-stimulating factor (G-CSF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling]
synonym: "CSF3R" RELATED [GOC:bf]
synonym: "G-CSF receptor activity" EXACT [GOC:bf]
synonym: "granulocyte colony stimulating factor receptor activity" EXACT []
is_a: GO:0004896 ! cytokine receptor activity
relationship: has_part GO:0051916 ! granulocyte colony-stimulating factor binding
relationship: part_of GO:0038158 ! granulocyte colony-stimulating factor signaling pathway

[Term]
id: GO:0004903
name: growth hormone receptor activity
namespace: molecular_function
def: "Combining with a growth hormone and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:ai, GOC:signaling]
is_a: GO:0004896 ! cytokine receptor activity

[Term]
id: GO:0004904
name: interferon receptor activity
namespace: molecular_function
def: "Combining with an interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:ai, GOC:signaling, PMID:9607096]
synonym: "IFN receptor activity" EXACT [GOC:mah]
is_a: GO:0004896 ! cytokine receptor activity
relationship: has_part GO:0019961 ! interferon binding

[Term]
id: GO:0004905
name: type I interferon receptor activity
namespace: molecular_function
def: "Combining with a type I interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:signaling, ISBN:0126896631, PMID:15546383, PMID:16681834, PR:000025848]
synonym: "interferon-alpha receptor activity" NARROW []
synonym: "interferon-alpha/beta receptor activity" NARROW []
synonym: "interferon-beta receptor activity" NARROW []
synonym: "interferon-delta receptor activity" NARROW []
synonym: "interferon-epsilon receptor activity" NARROW []
synonym: "interferon-kappa receptor activity" NARROW []
synonym: "interferon-omega receptor activity" NARROW []
synonym: "interferon-tau receptor activity" NARROW []
synonym: "interferon-zeta receptor activity" NARROW []
synonym: "type I IFN receptor activity" EXACT [GOC:mah]
is_a: GO:0004904 ! interferon receptor activity
relationship: has_part GO:0019962 ! type I interferon binding
relationship: part_of GO:0060337 ! type I interferon signaling pathway

[Term]
id: GO:0004906
name: interferon-gamma receptor activity
namespace: molecular_function
def: "Combining with interferon-gamma (a type II interferon) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:ai, GOC:signaling, ISBN:0126896631, PMID:15546383]
synonym: "IFN-gamma receptor activity" EXACT [GOC:mah]
synonym: "IFNG receptor activity" EXACT [GOC:mah]
synonym: "type II interferon receptor activity" BROAD []
is_a: GO:0004904 ! interferon receptor activity
relationship: has_part GO:0019964 ! interferon-gamma binding
relationship: part_of GO:0060333 ! interferon-gamma-mediated signaling pathway

[Term]
id: GO:0004908
name: interleukin-1 receptor activity
namespace: molecular_function
def: "Combining with interleukin-1 to initiate a change in cell activity. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response." [GOC:jl]
synonym: "IL-1 receptor activity" EXACT []
synonym: "IL-1R" EXACT []
xref: Wikipedia:Interleukin-1_receptor
is_a: GO:0004896 ! cytokine receptor activity
relationship: has_part GO:0019966 ! interleukin-1 binding

[Term]
id: GO:0004909
name: interleukin-1, Type I, activating receptor activity
namespace: molecular_function
alt_id: GO:0019967
def: "Combining with interleukin-1 to initiate a change in cell activity via signaling pathways and mediated by adaptor proteins." [PMID:15062641, PMID:18613828]
synonym: "IL-1 type I, activating binding" EXACT []
synonym: "IL-1 type I, activating receptor" EXACT []
synonym: "interleukin-1 activating receptor activity" EXACT [GOC:mah]
synonym: "interleukin-1 Type I receptor activity" EXACT [GOC:mah]
synonym: "interleukin-1, Type I, activating binding" RELATED []
is_a: GO:0004908 ! interleukin-1 receptor activity
relationship: part_of GO:0070498 ! interleukin-1-mediated signaling pathway

[Term]
id: GO:0004910
name: interleukin-1, Type II, blocking receptor activity
namespace: molecular_function
alt_id: GO:0019968
def: "Combining with interleukin-1 to initiate a change in cell activity by inhibiting the activity of type I interleukin receptors." [PMID:15062641, PMID:18613828]
synonym: "IL-1 type II, blocking binding" EXACT []
synonym: "IL-1 type II, blocking receptor" EXACT []
synonym: "interleukin-1 blocking receptor activity" EXACT [GOC:mah]
synonym: "interleukin-1 Type II receptor activity" EXACT [GOC:mah]
synonym: "interleukin-1, Type II, blocking binding" RELATED []
is_a: GO:0004908 ! interleukin-1 receptor activity

[Term]
id: GO:0004911
name: interleukin-2 receptor activity
namespace: molecular_function
def: "Combining with interleukin-2 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
synonym: "IL-2 receptor activity" EXACT [GOC:mah]
synonym: "IL-2R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity
relationship: has_part GO:0019976 ! interleukin-2 binding
relationship: part_of GO:0038110 ! interleukin-2-mediated signaling pathway

[Term]
id: GO:0004912
name: interleukin-3 receptor activity
namespace: molecular_function
def: "Combining with interleukin-3 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
synonym: "IL-3 receptor activity" EXACT [GOC:mah]
synonym: "IL-3R" EXACT []
xref: Wikipedia:Interleukin-3_receptor
is_a: GO:0004896 ! cytokine receptor activity
relationship: has_part GO:0019978 ! interleukin-3 binding
relationship: part_of GO:0036016 ! cellular response to interleukin-3
relationship: part_of GO:0038156 ! interleukin-3-mediated signaling pathway

[Term]
id: GO:0004913
name: interleukin-4 receptor activity
namespace: molecular_function
def: "Combining with interleukin-4 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
synonym: "IL-4 receptor activity" EXACT [GOC:mah]
synonym: "IL-4R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity
relationship: has_part GO:0019979 ! interleukin-4 binding
relationship: part_of GO:0035771 ! interleukin-4-mediated signaling pathway

[Term]
id: GO:0004914
name: interleukin-5 receptor activity
namespace: molecular_function
def: "Combining with interleukin-5 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
synonym: "IL-5 receptor activity" EXACT [GOC:mah]
synonym: "IL-5R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity
relationship: has_part GO:0019980 ! interleukin-5 binding
relationship: part_of GO:0038043 ! interleukin-5-mediated signaling pathway

[Term]
id: GO:0004915
name: interleukin-6 receptor activity
namespace: molecular_function
def: "Combining with interleukin-6 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
synonym: "gp130" RELATED []
synonym: "IL-6 receptor activity" EXACT [GOC:mah]
synonym: "IL-6R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity
relationship: has_part GO:0019981 ! interleukin-6 binding
relationship: part_of GO:0070102 ! interleukin-6-mediated signaling pathway

[Term]
id: GO:0004917
name: interleukin-7 receptor activity
namespace: molecular_function
def: "Combining with interleukin-7 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
synonym: "IL-7 receptor activity" EXACT [GOC:mah]
synonym: "IL-7R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity
relationship: has_part GO:0019982 ! interleukin-7 binding
relationship: part_of GO:0038111 ! interleukin-7-mediated signaling pathway

[Term]
id: GO:0004918
name: interleukin-8 receptor activity
namespace: molecular_function
def: "Combining with interleukin-8 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
synonym: "IL-8 receptor activity" EXACT [GOC:mah]
synonym: "IL-8R" EXACT []
is_a: GO:0016494 ! C-X-C chemokine receptor activity
relationship: has_part GO:0019959 ! interleukin-8 binding
relationship: part_of GO:0038112 ! interleukin-8-mediated signaling pathway

[Term]
id: GO:0004919
name: interleukin-9 receptor activity
namespace: molecular_function
def: "Combining with interleukin-9 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
synonym: "IL-9 receptor activity" EXACT [GOC:mah]
synonym: "IL-9R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity
relationship: has_part GO:0019983 ! interleukin-9 binding
relationship: part_of GO:0038113 ! interleukin-9-mediated signaling pathway

[Term]
id: GO:0004920
name: interleukin-10 receptor activity
namespace: molecular_function
def: "Combining with interleukin-10 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
synonym: "IL-10 receptor activity" EXACT [GOC:mah]
synonym: "IL-10R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity
relationship: has_part GO:0019969 ! interleukin-10 binding

[Term]
id: GO:0004921
name: interleukin-11 receptor activity
namespace: molecular_function
def: "Combining with interleukin-11 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
synonym: "gp130" RELATED []
synonym: "IL-11 receptor activity" EXACT [GOC:mah]
synonym: "IL-11R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity
relationship: has_part GO:0019970 ! interleukin-11 binding
relationship: part_of GO:0038154 ! interleukin-11-mediated signaling pathway

[Term]
id: GO:0004923
name: leukemia inhibitory factor receptor activity
namespace: molecular_function
alt_id: GO:0004899
def: "Combining with leukemia inhibitory factor (LIF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, GOC:mah, GOC:signaling]
synonym: "leukemia inhibitory factor receptor beta-protein activity" NARROW [GOC:mah]
synonym: "LIF receptor activity" EXACT [GOC:mah]
is_a: GO:0004897 ! ciliary neurotrophic factor receptor activity
relationship: part_of GO:0048861 ! leukemia inhibitory factor signaling pathway

[Term]
id: GO:0004924
name: oncostatin-M receptor activity
namespace: molecular_function
def: "Combining with oncostatin-M and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling]
is_a: GO:0004896 ! cytokine receptor activity
relationship: part_of GO:0038165 ! oncostatin-M-mediated signaling pathway

[Term]
id: GO:0004925
name: prolactin receptor activity
namespace: molecular_function
def: "Combining with prolactin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling]
is_a: GO:0004896 ! cytokine receptor activity
relationship: part_of GO:0038161 ! prolactin signaling pathway

[Term]
id: GO:0004927
name: obsolete sevenless receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a gene product rather than an activity.
synonym: "sevenless receptor activity" EXACT []
is_obsolete: true
consider: GO:0004714
consider: GO:0004888
consider: GO:0008288

[Term]
id: GO:0004928
name: obsolete frizzled receptor activity
namespace: molecular_function
def: "OBSOLETE. Combining with a member of the Wnt-family of signaling molecules to initiate a change in cell activity." [GOC:go_curators]
comment: This term was made obsolete because it represents a gene product rather than an activity.
synonym: "frizzled receptor activity" EXACT []
is_obsolete: true
replaced_by: GO:0042813
consider: GO:0016055

[Term]
id: GO:0004929
name: obsolete frizzled-2 receptor activity
namespace: molecular_function
def: "OBSOLETE. Combining with to a member of the Wnt-family of signaling molecules to initiate a change in cell activity." [GOC:go_curators]
comment: This term was made obsolete because it represents a gene product rather than an activity.
synonym: "frizzled-2 receptor activity" EXACT []
is_obsolete: true
replaced_by: GO:0042813
consider: GO:0007223

[Term]
id: GO:0004930
name: G-protein coupled receptor activity
namespace: molecular_function
alt_id: GO:0001622
alt_id: GO:0001623
alt_id: GO:0001624
alt_id: GO:0001625
alt_id: GO:0016526
def: "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
subset: goslim_chembl
subset: gosubset_prok
synonym: "EBV-induced receptor" NARROW []
synonym: "Epstein-Barr Virus-induced receptor activity" NARROW []
synonym: "G protein coupled receptor activity" EXACT []
synonym: "G protein linked receptor activity" EXACT []
synonym: "G-protein coupled receptor activity, unknown ligand" NARROW []
synonym: "G-protein linked receptor activity" EXACT []
synonym: "G-protein-coupled receptor activity" EXACT []
synonym: "GPCR activity" EXACT []
synonym: "ligand-dependent GPCR activity" EXACT []
synonym: "Mas proto-oncogene receptor activity" NARROW []
synonym: "orphan G protein coupled receptor activity" NARROW []
synonym: "orphan G-protein coupled receptor activity" NARROW []
synonym: "orphan GPCR activity" NARROW []
synonym: "RDC1 receptor activity" NARROW []
synonym: "receptor activity, G-protein coupled" EXACT [GOC:bf]
synonym: "SREB receptor" NARROW []
synonym: "super conserved receptor expressed in brain receptor activity" NARROW []
xref: Reactome:REACT_100062 "G12/13 activation by PAR, Sus scrofa"
xref: Reactome:REACT_100632 "The high affinity receptor complex binds to G-protein, Mus musculus"
xref: Reactome:REACT_101654 "G12/13 activation by PAR, Taeniopygia guttata"
xref: Reactome:REACT_108337 "Gq activation by PAR, Gallus gallus"
xref: Reactome:REACT_108705 "The high affinity receptor complex binds to G-protein, Gallus gallus"
xref: Reactome:REACT_109480 "Gq activation by PAR, Bos taurus"
xref: Reactome:REACT_109715 "The high affinity receptor complex binds to G-protein, Danio rerio"
xref: Reactome:REACT_110075 "G12/13 activation by PAR, Bos taurus"
xref: Reactome:REACT_1430 "Gq activation by PAR, Homo sapiens"
xref: Reactome:REACT_15298 "The high affinity receptor complex binds to G-protein, Homo sapiens"
xref: Reactome:REACT_28243 "Gq activation by PAR, Rattus norvegicus"
xref: Reactome:REACT_29193 "G12/13 activation by PAR, Rattus norvegicus"
xref: Reactome:REACT_29686 "Gq activation by PAR, Canis familiaris"
xref: Reactome:REACT_30471 "G12/13 activation by PAR, Mus musculus"
xref: Reactome:REACT_32708 "G12/13 activation by PAR, Canis familiaris"
xref: Reactome:REACT_32983 "Gq activation by PAR, Danio rerio"
xref: Reactome:REACT_34075 "The high affinity receptor complex binds to G-protein, Taeniopygia guttata"
xref: Reactome:REACT_637 "G12/13 activation by PAR, Homo sapiens"
xref: Reactome:REACT_77079 "G12/13 activation by PAR, Danio rerio"
xref: Reactome:REACT_78692 "The high affinity receptor complex binds to G-protein, Xenopus tropicalis"
xref: Reactome:REACT_79526 "Gq activation by PAR, Sus scrofa"
xref: Reactome:REACT_85249 "The high affinity receptor complex binds to G-protein, Canis familiaris"
xref: Reactome:REACT_85989 "Gq activation by PAR, Taeniopygia guttata"
xref: Reactome:REACT_86240 "G12/13 activation by PAR, Gallus gallus"
xref: Reactome:REACT_92494 "The high affinity receptor complex binds to G-protein, Bos taurus"
xref: Reactome:REACT_95526 "Gq activation by PAR, Mus musculus"
xref: Reactome:REACT_97825 "Gq activation by PAR, Xenopus tropicalis"
xref: Reactome:REACT_98882 "G12/13 activation by PAR, Xenopus tropicalis"
xref: Wikipedia:GPCR
is_a: GO:0004888 ! transmembrane signaling receptor activity
relationship: part_of GO:0007186 ! G-protein coupled receptor signaling pathway

[Term]
id: GO:0004931
name: extracellular ATP-gated cation channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a cation by a channel that opens when extracellular ATP has been bound by the channel complex or one of its constituent parts." [GOC:bf, GOC:mah, PMID:9755289]
comment: Note that this term refers to an activity and not a gene product. Consider also annotating to the molecular function term 'purinergic nucleotide receptor activity ; GO:0001614'.
synonym: "P2X receptor" RELATED [PMID:9755289]
synonym: "purinoceptor" BROAD []
synonym: "purinoreceptor" BROAD []
xref: Reactome:REACT_75889 "P2X7 mediates loss of intracellular K+, Homo sapiens"
is_a: GO:0005231 ! excitatory extracellular ligand-gated ion channel activity
is_a: GO:0005261 ! cation channel activity
is_a: GO:0035381 ! ATP-gated ion channel activity

[Term]
id: GO:0004932
name: mating-type factor pheromone receptor activity
namespace: molecular_function
def: "Combining with a mating-type factor pheromone to initiate a change in cell activity." [GOC:dph, GOC:vw]
subset: gosubset_prok
is_a: GO:0008528 ! G-protein coupled peptide receptor activity
is_a: GO:0016503 ! pheromone receptor activity

[Term]
id: GO:0004933
name: mating-type a-factor pheromone receptor activity
namespace: molecular_function
def: "Combining with the mating-type a-factor pheromone to initiate a change in cell activity." [GOC:mah]
synonym: "class D G protein coupled receptor activity" BROAD []
synonym: "class D G-protein coupled receptor activity" BROAD []
synonym: "class D G-protein-coupled receptor activity" BROAD []
synonym: "class D GPCR activity" BROAD []
is_a: GO:0004932 ! mating-type factor pheromone receptor activity
is_a: GO:0036318 ! peptide pheromone receptor activity

[Term]
id: GO:0004934
name: mating-type alpha-factor pheromone receptor activity
namespace: molecular_function
def: "Combining with the mating-type alpha-factor pheromone to initiate a change in cell activity." [GOC:mah]
synonym: "class D G protein coupled receptor activity" BROAD []
synonym: "class D G-protein coupled receptor activity" BROAD []
synonym: "class D G-protein-coupled receptor activity" BROAD []
synonym: "class D GPCR activity" BROAD []
is_a: GO:0004932 ! mating-type factor pheromone receptor activity
is_a: GO:0036318 ! peptide pheromone receptor activity

[Term]
id: GO:0004935
name: adrenergic receptor activity
namespace: molecular_function
def: "Combining with epinephrine or norepinephrine and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex." [GOC:bf, GOC:mah, IUPHAR_GPCR:1274]
synonym: "adrenoceptor activity" EXACT []
xref: Wikipedia:Adrenergic_receptor
is_a: GO:0008227 ! G-protein coupled amine receptor activity
relationship: part_of GO:0071875 ! adrenergic receptor signaling pathway

[Term]
id: GO:0004936
name: alpha-adrenergic receptor activity
namespace: molecular_function
def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha-adrenergic receptors." [GOC:mah, IUPHAR_GPCR:1274]
synonym: "alpha adrenoceptor" EXACT []
is_a: GO:0004935 ! adrenergic receptor activity

[Term]
id: GO:0004937
name: alpha1-adrenergic receptor activity
namespace: molecular_function
def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein." [GOC:cb, GOC:mah, IUPHAR_GPCR:1274]
synonym: "alpha1 adrenoceptor" EXACT []
is_a: GO:0004936 ! alpha-adrenergic receptor activity

[Term]
id: GO:0004938
name: alpha2-adrenergic receptor activity
namespace: molecular_function
def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha2-adrenergic receptors; the activity involves transmitting the signal to the Gi alpha subunit of a heterotrimeric G protein." [GOC:cb, GOC:mah, IUPHAR_GPCR:1274]
synonym: "alpha2 adrenoceptor" EXACT []
is_a: GO:0004936 ! alpha-adrenergic receptor activity

[Term]
id: GO:0004939
name: beta-adrenergic receptor activity
namespace: molecular_function
def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors; the activity involves transmitting the signal to the Gs alpha subunit of a heterotrimeric G protein." [GOC:cb, GOC:mah, IUPHAR_GPCR:1274]
synonym: "beta adrenoceptor" EXACT []
is_a: GO:0004935 ! adrenergic receptor activity

[Term]
id: GO:0004940
name: beta1-adrenergic receptor activity
namespace: molecular_function
def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta1-adrenergic receptors." [GOC:mah, IUPHAR_GPCR:1274]
synonym: "beta1 adrenoceptor" EXACT []
is_a: GO:0004939 ! beta-adrenergic receptor activity

[Term]
id: GO:0004941
name: beta2-adrenergic receptor activity
namespace: molecular_function
def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta2-adrenergic receptors." [GOC:mah, IUPHAR_GPCR:1274]
synonym: "beta2 adrenoceptor" EXACT []
is_a: GO:0004939 ! beta-adrenergic receptor activity

[Term]
id: GO:0004942
name: anaphylatoxin receptor activity
namespace: molecular_function
def: "Combining with anaphylatoxin to initiate a change in cell activity." [GOC:ai]
is_a: GO:0008528 ! G-protein coupled peptide receptor activity

[Term]
id: GO:0004943
name: C3a anaphylatoxin receptor activity
namespace: molecular_function
def: "Combining with anaphylatoxin C3a to initiate a change in cell activity." [GOC:mah]
is_a: GO:0004942 ! anaphylatoxin receptor activity

[Term]
id: GO:0004944
name: C5a anaphylatoxin receptor activity
namespace: molecular_function
def: "Combining with anaphylatoxin C5a to initiate a change in cell activity." [GOC:mah]
is_a: GO:0004942 ! anaphylatoxin receptor activity

[Term]
id: GO:0004945
name: angiotensin type II receptor activity
namespace: molecular_function
def: "An angiotensin receptor activity that acts via Gi protein coupling and cGMP (NO) generation, and may also act via additional signaling mechanisms." [GOC:mah, PMID:10977869]
is_a: GO:0001595 ! angiotensin receptor activity

[Term]
id: GO:0004946
name: bombesin receptor activity
namespace: molecular_function
def: "Combining with bombesin to initiate a change in cell activity." [GOC:ai]
is_a: GO:0008188 ! neuropeptide receptor activity
relationship: part_of GO:0031989 ! bombesin receptor signaling pathway

[Term]
id: GO:0004947
name: bradykinin receptor activity
namespace: molecular_function
def: "Combining with bradykinin to initiate a change in cell activity." [GOC:ai]
is_a: GO:0008528 ! G-protein coupled peptide receptor activity

[Term]
id: GO:0004948
name: calcitonin receptor activity
namespace: molecular_function
def: "Combining with calcitonin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:mah, GOC:signaling, PMID:21649645]
is_a: GO:0097642 ! calcitonin family receptor activity
relationship: has_part GO:0032841 ! calcitonin binding

[Term]
id: GO:0004949
name: cannabinoid receptor activity
namespace: molecular_function
def: "Combining with a cannabinoid to initiate a change in cell activity. Cannabinoids are a class of diverse chemical compounds that include the endocannabinoids and the phytocannabinoids." [GOC:dph, IUPHAR_GPCR:1279, Wikipedia:Cannabinoid]
synonym: "cannaboid receptor" EXACT []
synonym: "endocannabinoid receptor activity" NARROW [GOC:bf]
is_a: GO:0004930 ! G-protein coupled receptor activity
relationship: part_of GO:0038171 ! cannabinoid signaling pathway

[Term]
id: GO:0004950
name: chemokine receptor activity
namespace: molecular_function
def: "Combining with a chemokine, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria." [GOC:BHF, GOC:rl, GOC:signaling, http://en.wikipedia.org/wiki/Chemokine, IUPHAR_GPCR:1280, PMID:12183377, PMID:8662823]
is_a: GO:0001637 ! G-protein coupled chemoattractant receptor activity
is_a: GO:0004896 ! cytokine receptor activity
relationship: has_part GO:0019956 ! chemokine binding
relationship: part_of GO:0070098 ! chemokine-mediated signaling pathway

[Term]
id: GO:0004951
name: cholecystokinin receptor activity
namespace: molecular_function
def: "Combining with cholecystokinin and transmitting the signal across the membrane by activating an associated G-protein to initiate a change in cell activity. Cholecystokinin can act as a neuropeptide or as a gastrointestinal hormone." [GOC:signaling, PMID:9835394]
synonym: "CCK receptor activity" EXACT [PR:000005110, Wikipedia:Cholecystokinin]
is_a: GO:0008528 ! G-protein coupled peptide receptor activity
relationship: part_of GO:0038188 ! cholecystokinin signaling pathway

[Term]
id: GO:0004952
name: dopamine neurotransmitter receptor activity
namespace: molecular_function
def: "Combining with the neurotransmitter dopamine to initiate a change in cell activity." [IUPHAR_GPCR:1282]
is_a: GO:0099528 ! G-protein coupled neurotransmitter receptor activity
relationship: has_part GO:0035240 ! dopamine binding
relationship: part_of GO:0007212 ! dopamine receptor signaling pathway

[Term]
id: GO:0004953
name: icosanoid receptor activity
namespace: molecular_function
def: "Combining with an icosanoid to initiate a change in cell activity." [GOC:dph]
synonym: "eicosanoid receptor activity" EXACT []
is_a: GO:0004930 ! G-protein coupled receptor activity
relationship: has_part GO:0050542 ! icosanoid binding

[Term]
id: GO:0004954
name: prostanoid receptor activity
namespace: molecular_function
def: "Combining with a prostanoid, any compound based on or derived from the prostanoate structure, to initiate a change in cell activity." [ISBN:0198506732]
is_a: GO:0004953 ! icosanoid receptor activity

[Term]
id: GO:0004955
name: prostaglandin receptor activity
namespace: molecular_function
def: "Combining with a prostaglandin (PG) to initiate a change in cell activity." [ISBN:0198506732]
is_a: GO:0004954 ! prostanoid receptor activity

[Term]
id: GO:0004956
name: prostaglandin D receptor activity
namespace: molecular_function
def: "Combining with prostaglandin D (PGD(2)) to initiate a change in cell activity." [ISBN:0198506732]
synonym: "PGD receptor activity" RELATED []
synonym: "PGD(2) receptor activity" EXACT []
is_a: GO:0004955 ! prostaglandin receptor activity

[Term]
id: GO:0004957
name: prostaglandin E receptor activity
namespace: molecular_function
def: "Combining with prostaglandin E (PGE(2)) to initiate a change in cell activity." [ISBN:0198506732]
synonym: "PGE receptor activity" RELATED []
synonym: "PGE(2) receptor activity" EXACT []
is_a: GO:0004955 ! prostaglandin receptor activity

[Term]
id: GO:0004958
name: prostaglandin F receptor activity
namespace: molecular_function
def: "Combining with prostaglandin F (PGF (2-alpha)) to initiate a change in cell activity." [ISBN:0198506732]
synonym: "PGF receptor activity" RELATED []
synonym: "PGF(2-alpha) receptor activity" EXACT []
is_a: GO:0004955 ! prostaglandin receptor activity

[Term]
id: GO:0004960
name: thromboxane receptor activity
namespace: molecular_function
def: "Combining with a thromboxane (TXA) to initiate a change in cell activity." [ISBN:0198506732]
synonym: "TXA receptor activity" EXACT []
is_a: GO:0004954 ! prostanoid receptor activity

[Term]
id: GO:0004961
name: thromboxane A2 receptor activity
namespace: molecular_function
def: "Combining with thromboxane A2 (TXA(2)) and transmitting the signal across the membrane to activate an associated G-protein." [GOC:signaling, ISBN:0198506732]
synonym: "TXA(2) receptor activity" EXACT []
synonym: "TXA2 receptor activity" EXACT [PMID:15242977]
is_a: GO:0004960 ! thromboxane receptor activity
relationship: part_of GO:0038193 ! thromboxane A2 signaling pathway

[Term]
id: GO:0004962
name: endothelin receptor activity
namespace: molecular_function
alt_id: GO:0001599
alt_id: GO:0001600
def: "Combining with endothelin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph, GOC:signaling, IUPHAR_GPCR:1283, IUPHAR_RECEPTOR:2263, IUPHAR_RECEPTOR:2265]
synonym: "endothelin-A receptor activity" NARROW [GOC:bf, PMID:8582288]
synonym: "endothelin-B receptor activity" NARROW [GOC:bf, PMID:8582288]
is_a: GO:0008528 ! G-protein coupled peptide receptor activity
relationship: part_of GO:0086100 ! endothelin receptor signaling pathway

[Term]
id: GO:0004963
name: follicle-stimulating hormone receptor activity
namespace: molecular_function
def: "Combining with follicle-stimulating hormone to initiate a change in cell activity." [GOC:mah]
synonym: "follicle stimulating hormone receptor activity" EXACT []
synonym: "FSH receptor activity" EXACT []
is_a: GO:0016500 ! protein-hormone receptor activity
relationship: part_of GO:0042699 ! follicle-stimulating hormone signaling pathway

[Term]
id: GO:0004964
name: luteinizing hormone receptor activity
namespace: molecular_function
alt_id: GO:0004976
def: "Combining with luteinizing hormone (also called lutropin) to initiate a change in cell activity." [ISBN:0198506732, PMID:18848524, PMID:1922095]
synonym: "LH receptor" EXACT [PMID:18848524]
synonym: "LHR" EXACT [PMID:18848524]
synonym: "lutropin receptor" EXACT [ISBN:0198506732]
synonym: "lutropin-choriogonadotropic hormone receptor" RELATED [PMID:1922095]
is_a: GO:0016500 ! protein-hormone receptor activity
relationship: part_of GO:0042700 ! luteinizing hormone signaling pathway

[Term]
id: GO:0004965
name: G-protein coupled GABA receptor activity
namespace: molecular_function
def: "Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:ai, GOC:bf, IUPHAR_RECEPTOR:1276, Wikipedia:GABAB_receptor]
synonym: "GABA-B receptor activity" RELATED [GOC:bf]
synonym: "metabotropic GABA receptor" RELATED [Wikipedia:GABAB_receptor]
is_a: GO:0004930 ! G-protein coupled receptor activity
is_a: GO:0016917 ! GABA receptor activity

[Term]
id: GO:0004966
name: galanin receptor activity
namespace: molecular_function
def: "Combining with galanin to initiate a change in cell activity." [GOC:ai]
is_a: GO:0008188 ! neuropeptide receptor activity

[Term]
id: GO:0004967
name: glucagon receptor activity
namespace: molecular_function
def: "Combining with glucagon and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:mah, GOC:signaling, PMID:22438981]
is_a: GO:0008528 ! G-protein coupled peptide receptor activity
relationship: part_of GO:0071377 ! cellular response to glucagon stimulus

[Term]
id: GO:0004968
name: gonadotropin-releasing hormone receptor activity
namespace: molecular_function
def: "Combining with gonadotropin-releasing hormone to initiate a change in cell activity. Gonadotropin-releasing hormone (GnRH) is a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus." [GOC:mah]
synonym: "GnRH receptor activity" EXACT []
synonym: "gonadotrophin-releasing hormone receptor activity" EXACT [GOC:dph]
is_a: GO:0016500 ! protein-hormone receptor activity
relationship: has_part GO:0051448 ! gonadotropin-releasing hormone binding
relationship: part_of GO:0097211 ! cellular response to gonadotropin-releasing hormone

[Term]
id: GO:0004969
name: histamine receptor activity
namespace: molecular_function
def: "Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:ai]
is_a: GO:0008227 ! G-protein coupled amine receptor activity
relationship: has_part GO:0051381 ! histamine binding

[Term]
id: GO:0004970
name: ionotropic glutamate receptor activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]
comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'glutamate-gated ion channel activity ; GO:0005234' and 'cation channel activity ; GO:0005261'.
subset: gosubset_prok
is_a: GO:0008066 ! glutamate receptor activity
is_a: GO:0022824 ! transmitter-gated ion channel activity
relationship: part_of GO:0035235 ! ionotropic glutamate receptor signaling pathway

[Term]
id: GO:0004971
name: AMPA glutamate receptor activity
namespace: molecular_function
def: "An ionotropic glutamate receptor activity that exhibits fast gating by glutamate and acts by opening a cation channel permeable to sodium, potassium, and, in the absence of a GluR2 subunit, calcium." [GOC:mah, PMID:10049997, PMID:8804111]
comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'ionotropic glutamate receptor activity ; GO:0004970' and 'cation channel activity ; GO:0005261'.
synonym: "alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity" EXACT []
synonym: "AMPA receptor activity" EXACT []
is_a: GO:0004970 ! ionotropic glutamate receptor activity

[Term]
id: GO:0004972
name: NMDA glutamate receptor activity
namespace: molecular_function
def: "An ionotropic glutamate receptor activity that exhibits slow gating by glutamate, acts by opening a nonselective cation channel, and can be activated by L-aspartate." [GOC:mah, PMID:10049997]
comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'ionotropic glutamate receptor activity ; GO:0004970' and 'cation channel activity ; GO:0005261'.
synonym: "N-methyl-D-aspartate selective glutamate receptor activity" EXACT []
synonym: "NMDA receptor" EXACT []
xref: Wikipedia:NMDA_receptor
is_a: GO:0004970 ! ionotropic glutamate receptor activity

[Term]
id: GO:0004973
name: obsolete N-methyl-D-aspartate receptor-associated protein activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product and not a molecular function.
synonym: "N-methyl-D-aspartate receptor-associated protein activity" EXACT []
is_obsolete: true
consider: GO:0005102
consider: GO:0005515

[Term]
id: GO:0004974
name: leukotriene receptor activity
namespace: molecular_function
def: "Combining with a leukotriene to initiate a change in cell activity. Leukotrienes are pharmacologically active substances with a set of three conjugated double bonds; some contain a peptide group based on cysteine." [GOC:ai, ISBN:0198506732]
is_a: GO:0004953 ! icosanoid receptor activity
relationship: part_of GO:0061737 ! leukotriene signaling pathway

[Term]
id: GO:0004977
name: melanocortin receptor activity
namespace: molecular_function
def: "Combining with melanocortin to initiate a change in cell activity." [GOC:ai]
is_a: GO:0008528 ! G-protein coupled peptide receptor activity

[Term]
id: GO:0004978
name: corticotropin receptor activity
namespace: molecular_function
def: "Combining with corticotropin to initiate a change in cell activity." [GOC:ai]
synonym: "ACTH receptor activity" EXACT []
synonym: "adrenocorticotropic hormone receptor activity" EXACT []
synonym: "adrenocorticotropin receptor activity" EXACT []
is_a: GO:0004977 ! melanocortin receptor activity
is_a: GO:0008188 ! neuropeptide receptor activity
relationship: has_part GO:0042562 ! hormone binding

[Term]
id: GO:0004979
name: beta-endorphin receptor activity
namespace: molecular_function
def: "Combining with beta-endorphin, and transmitting the signal across the membrane by activating an associated G-protein. Beta-endorphin is a peptide, 31 amino acids long, resulting from processing of the precursor proopiomelanocortin (POMC)." [GOC:ai, GOC:bf, Wikipedia:Beta-endorphin]
synonym: "mu-opioid receptor activity" RELATED [GOC:bf]
is_a: GO:0004977 ! melanocortin receptor activity
is_a: GO:0004985 ! opioid receptor activity
is_a: GO:0008188 ! neuropeptide receptor activity
relationship: has_part GO:0031626 ! beta-endorphin binding

[Term]
id: GO:0004980
name: melanocyte-stimulating hormone receptor activity
namespace: molecular_function
def: "Combining with melanocyte-stimulating hormone to initiate a change in cell activity." [GOC:jl, PMID:7581459]
synonym: "melanocyte stimulating hormone receptor activity" EXACT []
synonym: "melanophore-stimulating hormone receptor activity" EXACT []
synonym: "MSH receptor activity" BROAD []
synonym: "MSHR activity" BROAD []
is_a: GO:0004977 ! melanocortin receptor activity
relationship: has_part GO:0042562 ! hormone binding

[Term]
id: GO:0004982
name: N-formyl peptide receptor activity
namespace: molecular_function
def: "Combining with an N-formyl peptide to initiate a change in cell activity." [GOC:ai]
synonym: "Fmet-leu-phe receptor" EXACT []
is_a: GO:0008528 ! G-protein coupled peptide receptor activity

[Term]
id: GO:0004983
name: neuropeptide Y receptor activity
namespace: molecular_function
def: "Combining with neuropeptide Y to initiate a change in cell activity." [PMID:9315606]
is_a: GO:0008188 ! neuropeptide receptor activity

[Term]
id: GO:0004984
name: olfactory receptor activity
namespace: molecular_function
def: "Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
synonym: "odorant receptor activity" EXACT [PMID:19135896, PMID:21041441]
is_a: GO:0004888 ! transmembrane signaling receptor activity
relationship: part_of GO:0050911 ! detection of chemical stimulus involved in sensory perception of smell

[Term]
id: GO:0004985
name: opioid receptor activity
namespace: molecular_function
def: "Combining with an opioid (any narcotic derived from or resembling opium), and transmitting the signal across the membrane by activating an associated G-protein." [CHEBI:60598, GOC:ai, GOC:bf, PMID:20494127]
is_a: GO:0008528 ! G-protein coupled peptide receptor activity
relationship: part_of GO:0038003 ! opioid receptor signaling pathway

[Term]
id: GO:0004986
name: obsolete delta-opioid receptor activity
namespace: molecular_function
def: "OBSOLETE. Combining with an opioid to initiate a change in cell activity, with the pharmacological characteristics of delta-opioid receptors, including the activity of enkephalins as ligands." [IUPHAR_RECEPTOR:317, PMID:10471416]
comment: This term was made obsolete because the receptor is defined based on its pharmacological properties.
synonym: "delta-opioid receptor activity" EXACT []
xref: Wikipedia:Delta_Opioid_receptor
is_obsolete: true
consider: GO:0038046

[Term]
id: GO:0004987
name: obsolete kappa-opioid receptor activity
namespace: molecular_function
def: "OBSOLETE. Combining with an opioid to initiate a change in cell activity, with the pharmacological characteristics of kappa-opioid receptors, including high affinity for dynorphins." [IUPHAR_RECEPTOR:318]
comment: This term was made obsolete because the receptor is defined based on its pharmacological properties.
synonym: "kappa-opioid receptor activity" EXACT []
xref: Wikipedia:Kappa_Opioid_receptor
is_obsolete: true
consider: GO:0038048

[Term]
id: GO:0004988
name: obsolete mu-opioid receptor activity
namespace: molecular_function
def: "OBSOLETE. Combining with an opioid to initiate a change in cell activity, with the pharmacological characteristics of mu-opioid receptors, including high affinity for enkephalins and beta-endorphin but low affinity for dynorphins." [IUPHAR_RECEPTOR:319]
comment: This term was made obsolete because the receptor is defined based on its pharmacological properties.
synonym: "mu-opioid receptor activity" EXACT []
xref: Wikipedia:Mu_Opioid_receptor
is_obsolete: true
consider: GO:0004979
consider: GO:0038046
consider: GO:0038047

[Term]
id: GO:0004989
name: octopamine receptor activity
namespace: molecular_function
def: "Combining with the biogenic amine octopamine to initiate a change in cell activity. Octopamine is found in both vertebrates and invertebrates and can have properties both of a hormone and a neurotransmitter and acts as an adrenergic agonist." [CHEBI:17134, GOC:ai]
is_a: GO:0008227 ! G-protein coupled amine receptor activity

[Term]
id: GO:0004990
name: oxytocin receptor activity
namespace: molecular_function
def: "Combining with oxytocin to initiate a change in cell activity." [GOC:ai]
is_a: GO:0008528 ! G-protein coupled peptide receptor activity

[Term]
id: GO:0004991
name: parathyroid hormone receptor activity
namespace: molecular_function
def: "Combining with parathyroid hormone to initiate a change in cell activity." [GOC:mah]
is_a: GO:0004930 ! G-protein coupled receptor activity

[Term]
id: GO:0004992
name: platelet activating factor receptor activity
namespace: molecular_function
def: "Combining with platelet activating factor to initiate a change in cell activity." [GOC:mah]
synonym: "PAF receptor activity" EXACT []
is_a: GO:0004930 ! G-protein coupled receptor activity

[Term]
id: GO:0004993
name: G-protein coupled serotonin receptor activity
namespace: molecular_function
alt_id: GO:0001585
alt_id: GO:0016609
def: "Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates." [CHEBI:28790, GOC:ai]
synonym: "5-HT receptor" EXACT []
synonym: "5-hydroxytryptamine receptor" EXACT []
synonym: "G protein coupled serotonin receptor activity" EXACT []
synonym: "G-protein-coupled serotonin receptor activity" EXACT []
xref: Wikipedia:5-HT_receptor
is_a: GO:0008227 ! G-protein coupled amine receptor activity
is_a: GO:0099589 ! serotonin receptor activity
relationship: has_part GO:0051378 ! serotonin binding
relationship: part_of GO:0007210 ! serotonin receptor signaling pathway

[Term]
id: GO:0004994
name: somatostatin receptor activity
namespace: molecular_function
def: "Combining with somatostatin to initiate a change in cell activity. Somatostatin is a peptide hormone that regulates the endocrine system by signaling via G-protein coupled somatostatin receptors. Somatostatin has two active forms produced by proteolytic cleavage: a 14 amino acid peptide (SST-14) and a 28 amino acid peptide (SST-28)." [GOC:ai, GOC:bf, Wikipedia:Somatostatin]
synonym: "GHIH receptor activity" EXACT [Wikipedia:Somatostatin]
synonym: "growth hormone-inhibiting hormone receptor activity" EXACT [Wikipedia:Somatostatin]
synonym: "somatotrophin release inhibiting factor receptor activity" EXACT [Wikipedia:Somatostatin]
synonym: "SRIF receptor activity" EXACT [Wikipedia:Somatostatin]
synonym: "SST receptor activity" EXACT [Wikipedia:Somatostatin]
is_a: GO:0008188 ! neuropeptide receptor activity
relationship: part_of GO:0038170 ! somatostatin signaling pathway

[Term]
id: GO:0004995
name: tachykinin receptor activity
namespace: molecular_function
def: "Combining with a tachykinin neuropeptide and transmitting the signal across the membrane by activating an associated G-protein." [GOC:ai, GOC:bf, PMID:7639617, Wikipedia:Tachykinin]
is_a: GO:0008188 ! neuropeptide receptor activity
relationship: part_of GO:0007217 ! tachykinin receptor signaling pathway

[Term]
id: GO:0004996
name: thyroid-stimulating hormone receptor activity
namespace: molecular_function
def: "Combining with thyroid-stimulating hormone to initiate a change in cell activity." [GOC:mah]
synonym: "thyroid stimulating hormone receptor activity" EXACT []
synonym: "thyrotropin receptor" EXACT []
synonym: "TSH receptor activity" EXACT []
xref: Wikipedia:Thyrotropin_receptor
is_a: GO:0016500 ! protein-hormone receptor activity
relationship: part_of GO:0038194 ! thyroid-stimulating hormone signaling pathway

[Term]
id: GO:0004997
name: thyrotropin-releasing hormone receptor activity
namespace: molecular_function
def: "Combining with thyrotropin-releasing hormone to initiate a change in cell activity." [GOC:mah]
is_a: GO:0004930 ! G-protein coupled receptor activity

[Term]
id: GO:0004998
name: transferrin receptor activity
namespace: molecular_function
def: "Combining selectively with transferrin, and delivering transferrin into the cell via endocytosis. Transferrin is a major iron carrier protein in vertebrates." [GOC:bf, PMID:2678449, PMID:3011819]
subset: gosubset_prok
is_a: GO:0038024 ! cargo receptor activity

[Term]
id: GO:0004999
name: vasoactive intestinal polypeptide receptor activity
namespace: molecular_function
def: "Combining with vasoactive intestinal polypeptide to initiate a change in cell activity." [GOC:mah]
is_a: GO:0004930 ! G-protein coupled receptor activity

[Term]
id: GO:0005000
name: vasopressin receptor activity
namespace: molecular_function
alt_id: GO:0016931
def: "Combining with vasopressin to initiate a change in cell activity." [GOC:ai]
synonym: "vasopressin activated calcium mobilizing receptor activity" NARROW []
is_a: GO:0008528 ! G-protein coupled peptide receptor activity

[Term]
id: GO:0005001
name: transmembrane receptor protein tyrosine phosphatase activity
namespace: molecular_function
def: "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
is_a: GO:0004725 ! protein tyrosine phosphatase activity
is_a: GO:0019198 ! transmembrane receptor protein phosphatase activity

[Term]
id: GO:0005003
name: ephrin receptor activity
namespace: molecular_function
def: "Combining with an ephrin to initiate a change in cell activity." [GOC:mah, PMID:9530499]
synonym: "Eph receptor activity" EXACT []
is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity
relationship: part_of GO:0048013 ! ephrin receptor signaling pathway

[Term]
id: GO:0005004
name: GPI-linked ephrin receptor activity
namespace: molecular_function
def: "Combining with a GPI-anchored ephrin to initiate a change in cell activity." [GOC:mah, PMID:9530499]
synonym: "GPI-linked Eph receptor activity" EXACT []
is_a: GO:0005003 ! ephrin receptor activity

[Term]
id: GO:0005005
name: transmembrane-ephrin receptor activity
namespace: molecular_function
def: "Combining with a transmembrane ephrin to initiate a change in cell activity." [GOC:mah, PMID:9530499]
synonym: "transmembrane-Eph receptor activity" EXACT []
is_a: GO:0005003 ! ephrin receptor activity

[Term]
id: GO:0005006
name: epidermal growth factor-activated receptor activity
namespace: molecular_function
alt_id: GO:0005023
def: "Combining with an epidermal growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:bf]
comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand EGF. For receptors that bind other growth factors, consider annotating to other terms under 'transmembrane signaling receptor activity ; GO:0004888.
subset: gosubset_prok
synonym: "EGF receptor activity" EXACT []
synonym: "EGFR" EXACT []
synonym: "epidermal growth factor receptor activity" EXACT [GOC:bf, GOC:signaling]
synonym: "TGF-alpha receptor activity" EXACT []
synonym: "transforming growth factor-alpha receptor activity" EXACT []
is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity
relationship: has_part GO:0048408 ! epidermal growth factor binding
relationship: part_of GO:0007173 ! epidermal growth factor receptor signaling pathway

[Term]
id: GO:0005007
name: fibroblast growth factor-activated receptor activity
namespace: molecular_function
def: "Combining with a fibroblast growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:mah]
comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand FGF. For receptors that bind other growth factors, consider annotating to terms under 'transmembrane signaling receptor activity ; GO:0004888.
synonym: "FGF receptor activity" EXACT []
synonym: "FGF-activated receptor activity" EXACT [GOC:bf, GOC:signaling]
synonym: "FGFR" EXACT []
synonym: "fibroblast growth factor receptor activity" EXACT [GOC:bf, GOC:signaling]
is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity
relationship: has_part GO:0017134 ! fibroblast growth factor binding
relationship: part_of GO:0008543 ! fibroblast growth factor receptor signaling pathway

[Term]
id: GO:0005008
name: hepatocyte growth factor-activated receptor activity
namespace: molecular_function
def: "Combining with hepatocyte growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:mah]
comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand HGF. For receptors that bind other growth factors, consider annotating to other terms under 'transmembrane signaling receptor activity ; GO:0004888.
synonym: "hepatocyte growth factor receptor activity" EXACT [GOC:bf, GOC:signaling]
synonym: "HGF receptor activity" EXACT []
synonym: "HGF-activated receptor activity" EXACT [GOC:bf, GOC:signaling]
is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity
relationship: has_part GO:0036458 ! hepatocyte growth factor binding
relationship: part_of GO:0048012 ! hepatocyte growth factor receptor signaling pathway

[Term]
id: GO:0005009
name: insulin-activated receptor activity
namespace: molecular_function
def: "Combining with insulin and transmitting the signal across the plasma membrane to initiate a change in cell activity." [ISBN:0198506732]
comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand insulin. For receptors that bind other extracellular ligands, consider annotating to other terms under 'transmembrane signaling receptor activity ; GO:0004888.
synonym: "insulin receptor activity" EXACT [GOC:bf, GOC:signaling]
is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity
relationship: has_part GO:0043559 ! insulin binding
relationship: part_of GO:0008286 ! insulin receptor signaling pathway

[Term]
id: GO:0005010
name: insulin-like growth factor-activated receptor activity
namespace: molecular_function
def: "Combining with insulin-like growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:mah]
comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand IGF. For receptors that bind other growth factors, consider annotating to other terms under 'transmembrane signaling receptor activity ; GO:0004888.
synonym: "IGF receptor activity" EXACT []
synonym: "IGF-activated receptor activity" EXACT [GOC:bf, GOC:signaling]
synonym: "insulin-like growth factor receptor activity" EXACT [GOC:bf, GOC:signaling]
is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity
relationship: has_part GO:0005520 ! insulin-like growth factor binding
relationship: part_of GO:0048009 ! insulin-like growth factor receptor signaling pathway

[Term]
id: GO:0005011
name: macrophage colony-stimulating factor receptor activity
namespace: molecular_function
def: "Combining with macrophage colony-stimulating factor (M-CSF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [GOC:mah, GOC:signaling]
synonym: "CSF-1" NARROW []
synonym: "Fms" NARROW []
synonym: "M-CSF receptor activity" EXACT [GOC:bf]
synonym: "macrophage colony stimulating factor receptor activity" EXACT []
is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity
relationship: part_of GO:0038145 ! macrophage colony-stimulating factor signaling pathway

[Term]
id: GO:0005012
name: obsolete Neu/ErbB-2 receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a class of receptor rather than an activity.
synonym: "Neu/ErbB-2 receptor activity" EXACT []
is_obsolete: true
consider: GO:0043125

[Term]
id: GO:0005013
name: obsolete neurotrophin TRK receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jid]
comment: This term was made obsolete because it represents a gene product.
synonym: "neurotrophin TRK receptor activity" EXACT []
is_obsolete: true
consider: GO:0004714
consider: GO:0007165
consider: GO:0019838
consider: GO:0043121

[Term]
id: GO:0005014
name: obsolete neurotrophin TRKA receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jid]
comment: This term was made obsolete because it represents a gene product.
synonym: "neurotrophin TRKA receptor activity" EXACT []
is_obsolete: true
consider: GO:0004714
consider: GO:0007165
consider: GO:0043121
consider: GO:0048406

[Term]
id: GO:0005015
name: obsolete neurotrophin TRKB receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jid]
comment: This term was made obsolete because it represents a gene product.
synonym: "neurotrophin TRKB receptor activity" EXACT []
is_obsolete: true
consider: GO:0004714
consider: GO:0007165
consider: GO:0043121
consider: GO:0048403

[Term]
id: GO:0005016
name: obsolete neurotrophin TRKC receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jid]
comment: This term was made obsolete because it represents a gene product.
synonym: "neurotrophin TRKC receptor activity" EXACT []
is_obsolete: true
consider: GO:0004714
consider: GO:0007165
consider: GO:0043121

[Term]
id: GO:0005017
name: platelet-derived growth factor-activated receptor activity
namespace: molecular_function
def: "Combining with platelet-derived growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:mah]
comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand PDGF. For receptors that bind other growth factors, consider annotating to other terms under 'transmembrane signaling receptor activity ; GO:0004888.
synonym: "PDGF receptor activity" EXACT []
synonym: "PDGF-activated receptor activity" EXACT [GOC:bf, GOC:signaling]
synonym: "PDGFR activity" EXACT []
synonym: "platelet-derived growth factor receptor activity" EXACT [GOC:bf, GOC:signaling]
is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity
relationship: has_part GO:0048407 ! platelet-derived growth factor binding
relationship: part_of GO:0036120 ! cellular response to platelet-derived growth factor stimulus
relationship: part_of GO:0048008 ! platelet-derived growth factor receptor signaling pathway

[Term]
id: GO:0005018
name: platelet-derived growth factor alpha-receptor activity
namespace: molecular_function
def: "Combining with platelet-derived growth factor isoform PDGF-AA, PDGF-BB or PDGF-AB to initiate a change in cell activity." [PMID:1657917]
synonym: "alphaPDGF receptor activity" EXACT [PMID:10372961]
synonym: "PDGF alpha-receptor activity" EXACT []
is_a: GO:0005017 ! platelet-derived growth factor-activated receptor activity
relationship: part_of GO:0035790 ! platelet-derived growth factor receptor-alpha signaling pathway

[Term]
id: GO:0005019
name: platelet-derived growth factor beta-receptor activity
namespace: molecular_function
def: "Combining with platelet-derived growth factor isoform PDGF-BB or PDGF-AB to initiate a change in cell activity." [PMID:1657917]
synonym: "betaPDGF receptor activity" RELATED [PMID:10372961]
synonym: "PDGF beta-receptor activity" EXACT []
is_a: GO:0005017 ! platelet-derived growth factor-activated receptor activity
relationship: part_of GO:0035791 ! platelet-derived growth factor receptor-beta signaling pathway

[Term]
id: GO:0005020
name: stem cell factor receptor activity
namespace: molecular_function
def: "Combining with stem cell factor (SCF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. Stem cell factor is a cytokine that stimulates mast cell growth and differentiation." [GOC:jl, GOC:signaling, PMID:10698217]
synonym: "KIT" RELATED [PR:000009345]
synonym: "KIT ligand receptor activity" EXACT [PR:000009345]
synonym: "KL receptor activity" EXACT [PR:000009345]
synonym: "SCF receptor activity" EXACT [PR:000009345]
is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity
relationship: part_of GO:0038109 ! Kit signaling pathway

[Term]
id: GO:0005021
name: vascular endothelial growth factor-activated receptor activity
namespace: molecular_function
def: "Combining with a vascular endothelial growth factor (VEGF) and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:mah, GOC:signaling]
comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand VEGF. For receptors that bind other growth factors, consider annotating to terms under 'transmembrane signaling receptor activity ; GO:0004888.
synonym: "vascular endothelial growth factor receptor activity" EXACT [GOC:bf, GOC:signaling]
synonym: "VEGF receptor activity" EXACT []
synonym: "VEGF-activated receptor activity" EXACT [GOC:bf, GOC:signaling]
synonym: "VEGFR activity" EXACT []
is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity
relationship: has_part GO:0038085 ! vascular endothelial growth factor binding
relationship: part_of GO:0038084 ! vascular endothelial growth factor signaling pathway

[Term]
id: GO:0005024
name: transforming growth factor beta-activated receptor activity
namespace: molecular_function
def: "Combining with a transforming growth factor beta (TGFbeta) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:mah, GOC:signaling]
comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand TGFbeta. For binding to other growth factors, consider annotating to terms under 'transmembrane signaling receptor activity ; GO:0004888.
synonym: "TGF-beta receptor activity" EXACT []
synonym: "TGFbeta receptor activity" EXACT []
synonym: "TGFbeta-activated receptor activity" EXACT [GOC:bf, GOC:signaling]
synonym: "TGFbetaR" EXACT []
synonym: "transforming growth factor beta receptor activity" EXACT [GOC:bf, GOC:signaling]
is_a: GO:0004675 ! transmembrane receptor protein serine/threonine kinase activity

[Term]
id: GO:0005025
name: transforming growth factor beta receptor activity, type I
namespace: molecular_function
def: "Combining with a complex of transforming growth factor beta and a type II TGF-beta receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of TGF-beta signals." [GOC:mah, Reactome:REACT_6945.1]
synonym: "transforming growth factor beta ligand binding to type I receptor" RELATED []
synonym: "type I TGF-beta receptor activity" EXACT []
synonym: "type I TGFbeta receptor activity" EXACT []
synonym: "type I transforming growth factor beta receptor activity" EXACT []
is_a: GO:0005024 ! transforming growth factor beta-activated receptor activity

[Term]
id: GO:0005026
name: transforming growth factor beta receptor activity, type II
namespace: molecular_function
def: "Combining with transforming growth factor beta to initiate a change in cell activity; upon ligand binding, binds to and catalyzes the phosphorylation of a type I TGF-beta receptor." [GOC:mah, Reactome:REACT_6872.1]
synonym: "transforming growth factor beta ligand binding to type II receptor" RELATED []
synonym: "type II TGF-beta receptor activity" EXACT []
synonym: "type II TGFbeta receptor activity" EXACT []
synonym: "type II transforming growth factor beta receptor activity" EXACT []
xref: Reactome:REACT_106771 "Type II receptor phosphorylates type I receptor, Bos taurus"
xref: Reactome:REACT_107794 "Type II receptor phosphorylates type I receptor, Xenopus tropicalis"
xref: Reactome:REACT_109796 "Type II receptor phosphorylates type I receptor, Rattus norvegicus"
xref: Reactome:REACT_34619 "Type II receptor phosphorylates type I receptor, Danio rerio"
xref: Reactome:REACT_6816 "Type II receptor phosphorylates type I receptor, Homo sapiens"
xref: Reactome:REACT_80573 "Type II receptor phosphorylates type I receptor, Canis familiaris"
xref: Reactome:REACT_85202 "Type II receptor phosphorylates type I receptor, Mus musculus"
xref: Reactome:REACT_95282 "Type II receptor phosphorylates type I receptor, Sus scrofa"
is_a: GO:0005024 ! transforming growth factor beta-activated receptor activity
relationship: has_part GO:0050431 ! transforming growth factor beta binding

[Term]
id: GO:0005027
name: obsolete NGF/TNF (6 C-domain) receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a protein family rather than a molecular function.
synonym: "NGF/TNF (6 C-domain) receptor activity" EXACT []
is_obsolete: true
consider: GO:0005031

[Term]
id: GO:0005028
name: obsolete CD40 receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it describes the receptor type, and not an activity.
synonym: "CD40 receptor activity" EXACT []
is_obsolete: true
consider: GO:0042615

[Term]
id: GO:0005029
name: obsolete CD27 receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it describes the receptor type, and not an activity.
synonym: "CD27 receptor activity" EXACT []
is_obsolete: true
consider: GO:0042614

[Term]
id: GO:0005030
name: neurotrophin receptor activity
namespace: molecular_function
def: "Combining with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth, and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling, http://www.mercksource.com/]
is_a: GO:0038023 ! signaling receptor activity
relationship: has_part GO:0043121 ! neurotrophin binding
relationship: part_of GO:0038179 ! neurotrophin signaling pathway

[Term]
id: GO:0005031
name: tumor necrosis factor-activated receptor activity
namespace: molecular_function
alt_id: GO:0005032
alt_id: GO:0005033
def: "Combining with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages, to initiate a change in cell function." [GOC:jl, http://lookwayup.com/]
synonym: "NGF/TNF (6 C-domain) receptor activity" NARROW []
synonym: "TNF receptor activity" EXACT []
synonym: "TNF receptor activity, type I" NARROW []
synonym: "TNF receptor activity, type II" NARROW []
synonym: "tumor necrosis factor receptor activity" EXACT [GOC:bf, GOC:signaling]
synonym: "tumor necrosis factor receptor activity, type I" NARROW []
synonym: "tumor necrosis factor receptor activity, type II" NARROW []
is_a: GO:0005035 ! death receptor activity
relationship: has_part GO:0043120 ! tumor necrosis factor binding
relationship: part_of GO:0033209 ! tumor necrosis factor-mediated signaling pathway

[Term]
id: GO:0005034
name: osmosensor activity
namespace: molecular_function
def: "Sensing extracellular osmolarity to initiate a change in cell activity, and spanning the membrane of the cell." [GOC:dph, GOC:tb]
is_a: GO:0004888 ! transmembrane signaling receptor activity

[Term]
id: GO:0005035
name: death receptor activity
namespace: molecular_function
def: "Combining with an extracellular messenger (called a death ligand), and transmitting the signal from one side of the plasma membrane to the other to initiate apoptotic or necrotic cell death." [GOC:bf, GOC:BHF, GOC:ecd, GOC:mtg_apoptosis, GOC:rl, PMID:10209153]
synonym: "apoptosis-activating receptor activity" RELATED [GOC:bf]
is_a: GO:0004888 ! transmembrane signaling receptor activity
relationship: part_of GO:0012501 ! programmed cell death

[Term]
id: GO:0005037
name: obsolete death receptor adaptor protein activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product and not a molecular function.
synonym: "death receptor adaptor protein activity" EXACT []
is_obsolete: true
consider: GO:0005123
consider: GO:0005515

[Term]
id: GO:0005038
name: obsolete death receptor interacting protein activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product and not a molecular function.
synonym: "death receptor interacting protein activity" EXACT []
is_obsolete: true
consider: GO:0005123
consider: GO:0005515

[Term]
id: GO:0005039
name: obsolete death receptor-associated factor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product and not a molecular function.
synonym: "death receptor-associated factor activity" EXACT []
is_obsolete: true
consider: GO:0005123
consider: GO:0005515

[Term]
id: GO:0005040
name: decoy death receptor activity
namespace: molecular_function
def: "Combining with an extracellular messenger (death ligand) without transmission of the signal. Decoy death receptors compete with death receptors for ligand binding, and do not initiate apoptosis." [GOC:bf, GOC:ecd, PMID:10209153]
is_a: GO:0004872 ! receptor activity

[Term]
id: GO:0005041
name: low-density lipoprotein receptor activity
namespace: molecular_function
alt_id: GO:0008032
def: "Combining with a low-density lipoprotein particle and delivering the low-density lipoprotein into the cell via endocytosis." [GOC:bf, ISBN:0198506732]
subset: gosubset_prok
synonym: "LDL receptor" EXACT []
synonym: "LDLR activity" EXACT [GOC:bf]
xref: Wikipedia:LDL_receptor
is_a: GO:0030228 ! lipoprotein particle receptor activity
relationship: has_part GO:0030169 ! low-density lipoprotein particle binding

[Term]
id: GO:0005042
name: netrin receptor activity
namespace: molecular_function
def: "Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:dph, GOC:signaling, PMID:15960985]
is_a: GO:0004888 ! transmembrane signaling receptor activity
relationship: part_of GO:0038007 ! netrin-activated signaling pathway

[Term]
id: GO:0005043
name: netrin receptor activity involved in chemorepulsion
namespace: molecular_function
def: "Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to contribute to the directed movement of a motile cell away from a higher concentration of netrin." [GOC:dph, GOC:signaling]
synonym: "netrin receptor activity involved in negative chemotaxis" EXACT [GOC:bf]
synonym: "repulsive netrin receptor activity" EXACT [GOC:bf]
is_a: GO:0005042 ! netrin receptor activity
intersection_of: GO:0005042 ! netrin receptor activity
intersection_of: part_of GO:0050919 ! negative chemotaxis
relationship: part_of GO:0050919 ! negative chemotaxis

[Term]
id: GO:0005044
name: scavenger receptor activity
namespace: molecular_function
def: "Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]
comment: Note that many gene products that are called scavenger receptors have a broad range of potential ligands and also can be annotated to 'pattern recognition receptor activity ; GO:0008329' or its child terms, or to 'lipoprotein receptor activity ; GO:0030228' or its child terms. For receptors that transduce a signal rather than endocytose their ligand, consider instead the terms 'signaling receptor activity ; GO:0038023' and its children.
subset: goslim_chembl
subset: gosubset_prok
synonym: "macrophage receptor activity" NARROW []
is_a: GO:0038024 ! cargo receptor activity

[Term]
id: GO:0005045
name: obsolete endoplasmic reticulum receptor activity
namespace: molecular_function
def: "OBSOLETE. A receptor in the endoplasmic reticulum." [GOC:ai]
comment: This term was made obsolete because it represents cellular component and molecular function information.
synonym: "endoplasmic reticulum receptor activity" EXACT []
is_obsolete: true
consider: GO:0004872
consider: GO:0005783

[Term]
id: GO:0005046
name: KDEL sequence binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a KDEL sequence, the C terminus tetrapeptide sequence Lys-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum." [GOC:ai]
synonym: "KDEL receptor activity" NARROW []
is_a: GO:0046923 ! ER retention sequence binding

[Term]
id: GO:0005047
name: signal recognition particle binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the signal recognition particle." [ISBN:0198506732]
comment: See also the cellular component term 'signal recognition particle, endoplasmic reticulum targeting ; GO:0005786'.
subset: gosubset_prok
synonym: "docking protein" BROAD []
synonym: "signal recognition particle receptor" NARROW []
is_a: GO:0043021 ! ribonucleoprotein complex binding

[Term]
id: GO:0005048
name: signal sequence binding
namespace: molecular_function
alt_id: GO:0008249
def: "Interacting selectively and non-covalently with a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized." [GOC:ai]
subset: gosubset_prok
synonym: "leader sequence binding" NARROW []
synonym: "protein signal sequence binding" NARROW []
synonym: "signal sequence receptor" NARROW []
xref: Reactome:REACT_100566 "Signal Recognition (Preproinsulin), Xenopus tropicalis"
xref: Reactome:REACT_102110 "Signal Recognition (Preproinsulin), Oryza sativa"
xref: Reactome:REACT_110574 "Signal Recognition (Preproinsulin), Caenorhabditis elegans"
xref: Reactome:REACT_112627 "Signal Recognition (Preproinsulin), Rattus norvegicus"
xref: Reactome:REACT_113110 "Signal Recognition (Preproinsulin), Gallus gallus"
xref: Reactome:REACT_15319 "Signal Recognition (Preproinsulin), Homo sapiens"
xref: Reactome:REACT_28213 "Signal Recognition (Preproinsulin), Danio rerio"
xref: Reactome:REACT_30312 "Signal Recognition (Preproinsulin), Taeniopygia guttata"
xref: Reactome:REACT_33457 "Signal Recognition (Preproinsulin), Dictyostelium discoideum"
xref: Reactome:REACT_79996 "Signal Recognition (Preproinsulin), Mus musculus"
xref: Reactome:REACT_82519 "Signal Recognition (Preproinsulin), Arabidopsis thaliana"
xref: Reactome:REACT_89495 "Signal Recognition (Preproinsulin), Drosophila melanogaster"
xref: Reactome:REACT_93460 "Signal Recognition (Preproinsulin), Canis familiaris"
is_a: GO:0042277 ! peptide binding

[Term]
id: GO:0005049
name: nuclear export signal receptor activity
namespace: molecular_function
alt_id: GO:0008262
def: "Combining with a nuclear export signal (NES) to mediate transport of the NES-containing protein through the nuclear pore to the cytoplasm." [GOC:bf, GOC:mah, GOC:vw, PMID:11743003, PMID:12486120]
synonym: "importin-alpha binding" RELATED []
synonym: "importin-alpha export receptor activity" NARROW [GO:0008262]
synonym: "NES receptor" EXACT []
is_a: GO:0005487 ! nucleocytoplasmic transporter activity
is_a: GO:0008565 ! protein transporter activity
relationship: part_of GO:0006611 ! protein export from nucleus

[Term]
id: GO:0005050
name: obsolete peroxisome receptor
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it describes a cellular component.
synonym: "peroxisome receptor" EXACT []
is_obsolete: true
consider: GO:0004872
consider: GO:0005777

[Term]
id: GO:0005052
name: peroxisome matrix targeting signal-1 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 1 peroxisome targeting signal, a tripeptide with the consensus sequence (S/A/C)-(K/R/H)-L." [GOC:mah, PMID:11687502]
synonym: "peroxisomal targeting signal 1 (PTS1) binding" EXACT [PMID:14709540]
synonym: "peroxisome targeting signal-1 binding" EXACT []
synonym: "peroxisome targeting signal-1 receptor" NARROW []
synonym: "PEX5" NARROW []
synonym: "PTS1 binding" EXACT [PMID:14709540]
synonym: "PTS1 receptor" NARROW []
is_a: GO:0000268 ! peroxisome targeting sequence binding

[Term]
id: GO:0005053
name: peroxisome matrix targeting signal-2 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 2 peroxisome targeting signal, a nonapeptide with a broad consensus sequence of (R/K)-(L/V/I)-(XXXXX)-(H/Q)-(L/A/F)." [GOC:mah, PMID:11687502]
synonym: "peroxisomal targeting signal 2 (PTS2) binding" EXACT [PMID:14709540]
synonym: "peroxisome targeting signal-2 binding" EXACT []
synonym: "peroxisome targeting signal-2 receptor" NARROW []
synonym: "PEX7" NARROW []
synonym: "PTS2 binding" EXACT [PMID:14709540]
synonym: "PTS2 receptor" EXACT []
is_a: GO:0000268 ! peroxisome targeting sequence binding

[Term]
id: GO:0005054
name: obsolete peroxisome integral membrane receptor
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it describes a cellular component.
synonym: "Pas20p" RELATED []
synonym: "peroxisome integral membrane receptor" EXACT []
is_obsolete: true
consider: GO:0004872
consider: GO:0005778

[Term]
id: GO:0005055
name: laminin receptor activity
namespace: molecular_function
def: "Combining with a laminin, a glycoprotein that constitutes the majority of proteins in the basement membrane, to initiate a change in cell activity." [GOC:ai, PMID:2970671]
comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'cell adhesion molecule binding ; GO:0050839' and 'receptor binding ; GO:0005102' and the biological process term 'cell adhesion ; GO:0007155'.
subset: gosubset_prok
is_a: GO:0004872 ! receptor activity
relationship: has_part GO:0043236 ! laminin binding

[Term]
id: GO:0005056
name: tiggrin receptor activity
namespace: molecular_function
def: "Combining with the extracellular matrix ligand tiggrin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling, PMID:9521906]
is_a: GO:0004888 ! transmembrane signaling receptor activity

[Term]
id: GO:0005057
name: receptor signaling protein activity
namespace: molecular_function
def: "Conveys a signal from an upstream receptor or intracellular signal transducer, converting the signal into a form where it can ultimately trigger a change in the state or activity of a cell." [GOC:bf]
comment: This term is intended for annotation of signal transducers that act directly or indirectly downstream of a receptor. For receptors themselves, consider annotating to the term 'receptor activity ; GO:0004872'.
synonym: "intracellular signal transducer activity" EXACT [GOC:bf]
synonym: "receptor signalling protein activity" EXACT []
is_a: GO:0004871 ! signal transducer activity

[Term]
id: GO:0005061
name: obsolete aryl hydrocarbon receptor nuclear translocator activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "aryl hydrocarbon receptor nuclear translocator activity" EXACT []
is_obsolete: true

[Term]
id: GO:0005065
name: obsolete heterotrimeric G-protein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a cellular component and not a molecular function.
synonym: "heterotrimeric G-protein" EXACT []
is_obsolete: true
replaced_by: GO:0005834

[Term]
id: GO:0005066
name: obsolete transmembrane receptor protein tyrosine kinase signaling protein activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because the meaning of the term is ambiguous and it incorporates process information.
synonym: "transmembrane receptor protein tyrosine kinase signaling protein activity" EXACT []
synonym: "transmembrane receptor protein tyrosine kinase signalling protein activity" EXACT []
is_obsolete: true
consider: GO:0004871
consider: GO:0007169
consider: GO:0035556

[Term]
id: GO:0005068
name: transmembrane receptor protein tyrosine kinase adaptor activity
namespace: molecular_function
alt_id: GO:0005069
def: "The binding activity of a molecule that brings together a transmembrane receptor protein tyrosine kinase and one or more other molecules, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07, PMID:10502414, PMID:20565848]
synonym: "transmembrane receptor protein tyrosine kinase adaptor protein activity" EXACT []
synonym: "transmembrane receptor protein tyrosine kinase docking protein activity" RELATED []
xref: Reactome:REACT_12454 "ARMS:Crk binds to active Trk receptor, Rattus norvegicus"
is_a: GO:0004871 ! signal transducer activity
is_a: GO:0030674 ! protein binding, bridging
is_a: GO:0030971 ! receptor tyrosine kinase binding
is_a: GO:0035591 ! signaling adaptor activity
relationship: part_of GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway

[Term]
id: GO:0005070
name: SH3/SH2 adaptor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68)." [GOC:mah, GOC:so]
synonym: "SH3/SH2 adaptor protein activity" NARROW []
is_a: GO:0030674 ! protein binding, bridging
is_a: GO:0035591 ! signaling adaptor activity

[Term]
id: GO:0005071
name: obsolete transmembrane receptor protein serine/threonine kinase signaling protein activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because the meaning of the term is ambiguous and it incorporates process information.
synonym: "transmembrane receptor protein serine/threonine kinase signaling protein activity" EXACT []
synonym: "transmembrane receptor protein serine/threonine kinase signalling protein activity" EXACT []
is_obsolete: true
consider: GO:0004871
consider: GO:0007178
consider: GO:0035556

[Term]
id: GO:0005072
name: transforming growth factor beta receptor, cytoplasmic mediator activity
namespace: molecular_function
def: "Activity of any of the molecules that transmit the signal from a TGF-beta receptor through the cytoplasm to the nucleus." [GOC:hjd]
comment: Note that this term and its children are useful for annotating proteins of the SMAD family.
synonym: "TGF-beta receptor, cytoplasmic mediator activity" EXACT []
synonym: "TGFbeta receptor, cytoplasmic mediator activity" EXACT []
is_a: GO:0005057 ! receptor signaling protein activity

[Term]
id: GO:0005073
name: obsolete common-partner SMAD protein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it names a family of gene products.
synonym: "common-partner SMAD protein" EXACT []
is_obsolete: true
replaced_by: GO:0030616

[Term]
id: GO:0005074
name: obsolete inhibitory SMAD protein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it names a family of gene products.
synonym: "inhibitory SMAD protein" EXACT []
is_obsolete: true
replaced_by: GO:0030617

[Term]
id: GO:0005075
name: obsolete pathway-specific SMAD protein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a family of gene products.
synonym: "pathway-specific SMAD protein" EXACT []
is_obsolete: true
replaced_by: GO:0030618

[Term]
id: GO:0005076
name: obsolete receptor signaling protein serine/threonine kinase signaling protein activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because the meaning of the term is ambiguous and it incorporates process information.
synonym: "receptor signaling protein serine/threonine kinase signaling protein activity" EXACT []
synonym: "receptor signalling protein serine/threonine kinase signalling protein activity" EXACT []
is_obsolete: true
consider: GO:0004871
consider: GO:0035556

[Term]
id: GO:0005077
name: obsolete MAP-kinase anchoring activity
namespace: molecular_function
def: "OBSOLETE. Binds to MAP kinase and anchors it to a particular subcellular location." [GOC:ai]
comment: This term was made obsolete because it represents a combination of process and function information.
synonym: "MAP-kinase anchor protein activity" EXACT []
synonym: "MAP-kinase anchoring activity" EXACT []
is_obsolete: true
consider: GO:0008104
consider: GO:0051019

[Term]
id: GO:0005078
name: MAP-kinase scaffold activity
namespace: molecular_function
def: "The binding activity of a molecule that functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. Binds multiple kinases of the MAPKKK cascade, and also upstream signaling proteins, permitting those molecules to function in a coordinated way. Bringing together multiple enzymes and their substrates enables the signal to be transduced quickly and efficiently." [PMID:12511654, PMID:15213240, PMID:9405336]
synonym: "MAP-kinase scaffold protein activity" EXACT []
is_a: GO:0019900 ! kinase binding
is_a: GO:0032947 ! protein complex scaffold
is_a: GO:0035591 ! signaling adaptor activity

[Term]
id: GO:0005079
name: obsolete protein kinase A anchoring activity
namespace: molecular_function
def: "OBSOLETE. Binds to protein kinase A and anchors it to a particular subcellular location." [PMID:10354567]
comment: This term was made obsolete because it represents a combination of process and function information.
synonym: "A-kinase anchor protein activity" EXACT []
synonym: "AKAP activity" EXACT []
synonym: "protein kinase A anchoring activity" EXACT []
is_obsolete: true
consider: GO:0008104
consider: GO:0051018

[Term]
id: GO:0005080
name: protein kinase C binding
namespace: molecular_function
alt_id: GO:0072568
alt_id: GO:0072569
alt_id: GO:0097024
def: "Interacting selectively and non-covalently with protein kinase C." [GOC:jl]
synonym: "PKC alpha binding" EXACT []
synonym: "PKC binding" EXACT []
synonym: "PKC delta binding" EXACT [GOC:BHF, GOC:pr]
synonym: "PKC eta binding" EXACT [GOC:BHF, GOC:pr]
synonym: "protein kinase C alpha binding" NARROW []
synonym: "protein kinase C delta binding" NARROW []
synonym: "protein kinase C eta binding" NARROW []
is_a: GO:0019901 ! protein kinase binding

[Term]
id: GO:0005081
name: obsolete receptor signaling protein serine/threonine phosphatase signaling protein activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because the meaning of the term is ambiguous and it incorporates process information.
synonym: "receptor signaling protein serine/threonine phosphatase signaling protein activity" EXACT []
synonym: "receptor signalling protein serine/threonine phosphatase signalling protein activity" EXACT []
is_obsolete: true
consider: GO:0004871
consider: GO:0035556

[Term]
id: GO:0005082
name: obsolete receptor signaling protein tyrosine phosphatase signaling protein activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because the meaning of the term is ambiguous and it incorporates process information.
synonym: "receptor signaling protein tyrosine phosphatase signaling protein activity" EXACT []
synonym: "receptor signalling protein tyrosine phosphatase signalling protein activity" EXACT []
is_obsolete: true
consider: GO:0004871
consider: GO:0035556

[Term]
id: GO:0005085
name: guanyl-nucleotide exchange factor activity
namespace: molecular_function
alt_id: GO:0008433
alt_id: GO:0016219
alt_id: GO:0019839
def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]
comment: Note that guanyl-nucleotide exchange factor (GEF) activity alters binding affinity, but not GTPase catalytic activity directly. Therefore GO:0005085 is under 'regulation of GTPase activity' but is not a 'GTPase regulator', which is reserved for cases where the action of one gene product directly alters the rate of catalysis by another gene product.
subset: goslim_chembl
subset: goslim_yeast
subset: gosubset_prok
synonym: "GDP-dissociation stimulator activity" EXACT []
synonym: "GDS" EXACT []
synonym: "GEF" EXACT []
synonym: "GNRP" NARROW []
synonym: "guanyl-nucleotide release factor activity" EXACT []
synonym: "guanyl-nucleotide releasing factor" EXACT []
xref: Reactome:REACT_100054 "Liganded Gs-activating GPCR acts as a GEF for Gs, Gallus gallus"
xref: Reactome:REACT_100149 "(Frs2)C3G stimulates nucleotide exchange on Rap1, Bos taurus"
xref: Reactome:REACT_100160 "Liganded Gi-activating GPCR acts as a GEF for Gi, Dictyostelium discoideum"
xref: Reactome:REACT_100220 "Liganded Gs-activating GPCR acts as a GEF for Gs, Sus scrofa"
xref: Reactome:REACT_100376 "C3G stimulates nucleotide exchange on Rap1, Bos taurus"
xref: Reactome:REACT_100844 "Activation of Cdc42 by pVav1, Rattus norvegicus"
xref: Reactome:REACT_100845 "Gi activation by P2Y purinoceptor 12, Gallus gallus"
xref: Reactome:REACT_100865 "Gq activation by P2Y purinoceptor 1, Rattus norvegicus"
xref: Reactome:REACT_101114 "Activation of Rap1 by membrane-associated GEFs, Sus scrofa"
xref: Reactome:REACT_101120 "Liganded Gi-activating GPCR acts as a GEF for Gi, Bos taurus"
xref: Reactome:REACT_101134 "Opsins that act as GEFs for G alpha-t, Mus musculus"
xref: Reactome:REACT_101148 "Activation of Rap1 by membrane-associated GEFs, Rattus norvegicus"
xref: Reactome:REACT_101201 "(Frs2)C3G stimulates nucleotide exchange on Rap1, Xenopus tropicalis"
xref: Reactome:REACT_101347 "Liganded Gz-activating GPCR acts as a GEF for Gz, Mus musculus"
xref: Reactome:REACT_101383 "Gs activation by prostacyclin receptor, Danio rerio"
xref: Reactome:REACT_101464 "Activation of Rap1 by membrane-associated GEFs, Caenorhabditis elegans"
xref: Reactome:REACT_101601 "Activation of Rac1 by pVav1, Rattus norvegicus"
xref: Reactome:REACT_102077 "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11, Sus scrofa"
xref: Reactome:REACT_102765 "Activation of Rac1 by pVav1, Gallus gallus"
xref: Reactome:REACT_103302 "Sar1p Activation And Membrane Binding, Danio rerio"
xref: Reactome:REACT_103339 "Liganded Gi-activating GPCR acts as a GEF for Gi, Taeniopygia guttata"
xref: Reactome:REACT_103405 "Activation of Cdc42 by pVav1, Xenopus tropicalis"
xref: Reactome:REACT_103624 "C3G stimulates nucleotide exchange on Rap1, Rattus norvegicus"
xref: Reactome:REACT_103967 "Liganded G12/13-activating GPCR acts as a GEF for G12/13, Taeniopygia guttata"
xref: Reactome:REACT_104045 "Liganded Gz-activating GPCR acts as a GEF for Gz, Bos taurus"
xref: Reactome:REACT_104400 "p115-RhoGEF activation of Rac1, Canis familiaris"
xref: Reactome:REACT_104431 "G13 activation by TP receptor, Rattus norvegicus"
xref: Reactome:REACT_104640 "G13 activation by TP receptor, Danio rerio"
xref: Reactome:REACT_104773 "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor, Gallus gallus"
xref: Reactome:REACT_105341 "VAV2 is a GEF for Rho/Rac family kinases, Caenorhabditis elegans"
xref: Reactome:REACT_105372 "Gq activation by P2Y purinoceptor 1, Xenopus tropicalis"
xref: Reactome:REACT_105430 "Gq activation by P2Y purinoceptor 1, Danio rerio"
xref: Reactome:REACT_105942 "Opsins that act as GEFs for G alpha-t, Danio rerio"
xref: Reactome:REACT_106103 "Liganded Gi-activating GPCR acts as a GEF for Gi, Sus scrofa"
xref: Reactome:REACT_106278 "Activation of Rap1 by cytosolic GEFs, Bos taurus"
xref: Reactome:REACT_106432 "Liganded Gi-activating GPCR acts as a GEF for Gi, Gallus gallus"
xref: Reactome:REACT_106521 "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11, Rattus norvegicus"
xref: Reactome:REACT_106839 "Activation of Rac1 by pVav1, Taeniopygia guttata"
xref: Reactome:REACT_106962 "Gq activation by TP receptor, Mus musculus"
xref: Reactome:REACT_107078 "Activation of Rac1 by pVav1, Canis familiaris"
xref: Reactome:REACT_107457 "Liganded G12/13-activating GPCR acts as a GEF for G12/13, Xenopus tropicalis"
xref: Reactome:REACT_108239 "Opsins that act as GEFs for G alpha-t, Bos taurus"
xref: Reactome:REACT_108491 "VAV2 is a GEF for Rho/Rac family kinases, Taeniopygia guttata"
xref: Reactome:REACT_108921 "Activation of Gq by Fatty Acid Receptor 1: Fatty Acid Complex, Canis familiaris"
xref: Reactome:REACT_109910 "Liganded Gz-activating GPCR acts as a GEF for Gz, Gallus gallus"
xref: Reactome:REACT_109998 "Gi activation by P2Y purinoceptor 12, Bos taurus"
xref: Reactome:REACT_110266 "Liganded Gs-activating GPCR acts as a GEF for Gs, Mus musculus"
xref: Reactome:REACT_110292 "Gs activation by prostacyclin receptor, Taeniopygia guttata"
xref: Reactome:REACT_110300 "Sar1p Activation And Membrane Binding, Oryza sativa"
xref: Reactome:REACT_110415 "(Frs2)C3G stimulates nucleotide exchange on Rap1, Mus musculus"
xref: Reactome:REACT_110820 "C3G stimulates nucleotide exchange on Rap1, Gallus gallus"
xref: Reactome:REACT_110821 "VAV3 is a GEF for Rho/Rac family kinases, Rattus norvegicus"
xref: Reactome:REACT_111195 "Activation of RAC1, Homo sapiens"
xref: Reactome:REACT_112168 "Activation of Gq by Muscarinic Acetylcholine Receptor M3, Danio rerio"
xref: Reactome:REACT_112243 "Activation of RAC1, Xenopus tropicalis"
xref: Reactome:REACT_112276 "VAV2 is a GEF for Rho/Rac family kinases, Schizosaccharomyces pombe"
xref: Reactome:REACT_112354 "Activation of RAC1, Mus musculus"
xref: Reactome:REACT_113007 "Activation of RAC1, Canis familiaris"
xref: Reactome:REACT_113090 "p115-RhoGEF activation of Rac1, Caenorhabditis elegans"
xref: Reactome:REACT_113408 "VAV2 is a GEF for Rho/Rac family kinases, Saccharomyces cerevisiae"
xref: Reactome:REACT_113526 "Activation of Rap1 by membrane-associated GEFs, Drosophila melanogaster"
xref: Reactome:REACT_113541 "p115-RhoGEF activation of Rac1, Xenopus tropicalis"
xref: Reactome:REACT_113598 "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor, Dictyostelium discoideum"
xref: Reactome:REACT_114659 "Activation of Gq by Fatty Acid Receptor 1: Fatty Acid Complex, Danio rerio"
xref: Reactome:REACT_114904 "VAV3 is a GEF for Rho/Rac family kinases, Saccharomyces cerevisiae"
xref: Reactome:REACT_115094 "VAV1 is a GEF for Rho/Rac family kinases, Caenorhabditis elegans"
xref: Reactome:REACT_115111 "VAV3 is a GEF for Rho/Rac family kinases, Schizosaccharomyces pombe"
xref: Reactome:REACT_115210 "Activation of RAC1, Drosophila melanogaster"
xref: Reactome:REACT_115748 "Rit is activated, Rattus norvegicus"
xref: Reactome:REACT_12037 "C3G stimulates nucleotide exchange on Rap1, Homo sapiens"
xref: Reactome:REACT_12071 "RIT/RIN are activated, Homo sapiens"
xref: Reactome:REACT_12083 "(Frs2)C3G stimulates nucleotide exchange on Rap1, Homo sapiens"
xref: Reactome:REACT_1214 "p115-RhoGEF activation of Rac1, Homo sapiens"
xref: Reactome:REACT_12453 "C3G stimulates nucleotide exchange on Rap1, Rattus norvegicus"
xref: Reactome:REACT_12554 "Sar1p Activation And Membrane Binding, Homo sapiens"
xref: Reactome:REACT_13694 "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor, Homo sapiens"
xref: Reactome:REACT_15291 "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11, Homo sapiens"
xref: Reactome:REACT_15507 "Activation of Rap1 by cytosolic GEFs, Homo sapiens"
xref: Reactome:REACT_15538 "Liganded Gi-activating GPCR acts as a GEF for Gi, Homo sapiens"
xref: Reactome:REACT_17008 "Liganded Gs-activating GPCR acts as a GEF for Gs, Homo sapiens"
xref: Reactome:REACT_18309 "Activation of Gq by Muscarinic Acetylcholine Receptor M3, Homo sapiens"
xref: Reactome:REACT_18400 "Opsins that act as GEFs for G alpha-t, Homo sapiens"
xref: Reactome:REACT_19243 "Activation of Rac1 by pVav1, Homo sapiens"
xref: Reactome:REACT_19286 "Activation of Cdc42 by pVav1, Homo sapiens"
xref: Reactome:REACT_19346 "Activation of Gq by Fatty Acid Receptor 1: Fatty Acid Complex, Homo sapiens"
xref: Reactome:REACT_20507 "Gi activation by P2Y purinoceptor 12, Homo sapiens"
xref: Reactome:REACT_20511 "Gq activation by TP receptor, Homo sapiens"
xref: Reactome:REACT_20567 "G13 activation by TP receptor, Homo sapiens"
xref: Reactome:REACT_20636 "Gq activation by P2Y purinoceptor 1, Homo sapiens"
xref: Reactome:REACT_22110 "Glucagon:GCGR mediates GTP-GDP exchange, Homo sapiens"
xref: Reactome:REACT_22134 "Activation of Gq by Muscarinic Acetylcholine Receptor M3 (mouse), Mus musculus"
xref: Reactome:REACT_22180 "Activation of Rac1 by VAV2, Homo sapiens"
xref: Reactome:REACT_22370 "Liganded G12/13-activating GPCR acts as a GEF for G12/13, Homo sapiens"
xref: Reactome:REACT_22380 "Liganded Gz-activating GPCR acts as a GEF for Gz, Homo sapiens"
xref: Reactome:REACT_23806 "VAV2 is a GEF for Rho/Rac family kinases, Homo sapiens"
xref: Reactome:REACT_23823 "Gs activation by prostacyclin receptor, Homo sapiens"
xref: Reactome:REACT_23833 "Activation of Rap1 by membrane-associated GEFs, Homo sapiens"
xref: Reactome:REACT_23936 "VAV3 is a GEF for Rho/Rac family kinases, Homo sapiens"
xref: Reactome:REACT_24016 "VAV1 is a GEF for Rho/Rac family kinases, Homo sapiens"
xref: Reactome:REACT_28676 "Liganded G12/13-activating GPCR acts as a GEF for G12/13, Bos taurus"
xref: Reactome:REACT_29276 "VAV2 is a GEF for Rho/Rac family kinases, Bos taurus"
xref: Reactome:REACT_29380 "Liganded G12/13-activating GPCR acts as a GEF for G12/13, Sus scrofa"
xref: Reactome:REACT_29556 "Regeneration of eEF1A:GTP by eEF1B activity, Mus musculus"
xref: Reactome:REACT_29675 "Liganded Gs-activating GPCR acts as a GEF for Gs, Xenopus tropicalis"
xref: Reactome:REACT_30010 "Liganded Gi-activating GPCR acts as a GEF for Gi, Mus musculus"
xref: Reactome:REACT_30405 "Gq activation by TP receptor, Gallus gallus"
xref: Reactome:REACT_30438 "VAV1 is a GEF for Rho/Rac family kinases, Xenopus tropicalis"
xref: Reactome:REACT_30603 "Liganded Gs-activating GPCR acts as a GEF for Gs, Taeniopygia guttata"
xref: Reactome:REACT_30730 "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor, Drosophila melanogaster"
xref: Reactome:REACT_30735 "Liganded G12/13-activating GPCR acts as a GEF for G12/13, Canis familiaris"
xref: Reactome:REACT_30905 "Opsins that act as GEFs for G alpha-t, Canis familiaris"
xref: Reactome:REACT_31044 "Sar1p Activation And Membrane Binding, Sus scrofa"
xref: Reactome:REACT_31228 "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11, Gallus gallus"
xref: Reactome:REACT_31456 "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11, Mus musculus"
xref: Reactome:REACT_31493 "VAV3 is a GEF for Rho/Rac family kinases, Drosophila melanogaster"
xref: Reactome:REACT_31796 "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor, Bos taurus"
xref: Reactome:REACT_31909 "Liganded Gz-activating GPCR acts as a GEF for Gz, Rattus norvegicus"
xref: Reactome:REACT_32415 "VAV2 is a GEF for Rho/Rac family kinases, Gallus gallus"
xref: Reactome:REACT_33219 "Gi activation by P2Y purinoceptor 12, Canis familiaris"
xref: Reactome:REACT_33232 "Activation of Gq by Muscarinic Acetylcholine Receptor M3, Xenopus tropicalis"
xref: Reactome:REACT_33439 "Activation of Rac1 by pVav1, Bos taurus"
xref: Reactome:REACT_33449 "(Frs2)C3G stimulates nucleotide exchange on Rap1, Danio rerio"
xref: Reactome:REACT_33674 "p115-RhoGEF activation of Rac1, Drosophila melanogaster"
xref: Reactome:REACT_33737 "G13 activation by TP receptor, Taeniopygia guttata"
xref: Reactome:REACT_34008 "Activation of Rap1 by cytosolic GEFs, Xenopus tropicalis"
xref: Reactome:REACT_34487 "Activation of Gq by Muscarinic Acetylcholine Receptor M3, Gallus gallus"
xref: Reactome:REACT_36332 "Sar1p Activation And Membrane Binding, Bos taurus"
xref: Reactome:REACT_44918 "Gi activation by P2Y purinoceptor 12, Rattus norvegicus"
xref: Reactome:REACT_6224 "GDP is exchanged for GTP on DRheb, Drosophila melanogaster"
xref: Reactome:REACT_67 "Regeneration of eEF1A:GTP by eEF1B activity, Homo sapiens"
xref: Reactome:REACT_77041 "Sar1p Activation And Membrane Binding, Canis familiaris"
xref: Reactome:REACT_77066 "Liganded Gz-activating GPCR acts as a GEF for Gz, Taeniopygia guttata"
xref: Reactome:REACT_77652 "G13 activation by TP receptor, Sus scrofa"
xref: Reactome:REACT_77906 "Liganded Gs-activating GPCR acts as a GEF for Gs, Danio rerio"
xref: Reactome:REACT_78375 "Liganded Gi-activating GPCR acts as a GEF for Gi, Danio rerio"
xref: Reactome:REACT_78455 "Gq activation by TP receptor, Xenopus tropicalis"
xref: Reactome:REACT_78720 "Liganded Gi-activating GPCR acts as a GEF for Gi, Rattus norvegicus"
xref: Reactome:REACT_78874 "Activation of Rap1 by cytosolic GEFs, Mus musculus"
xref: Reactome:REACT_78967 "Sar1p Activation And Membrane Binding, Rattus norvegicus"
xref: Reactome:REACT_79160 "Activation of Cdc42 by pVav1, Bos taurus"
xref: Reactome:REACT_79254 "Gq activation by TP receptor, Canis familiaris"
xref: Reactome:REACT_79314 "Activation of Rap1 by membrane-associated GEFs, Bos taurus"
xref: Reactome:REACT_79499 "Liganded Gz-activating GPCR acts as a GEF for Gz, Canis familiaris"
xref: Reactome:REACT_79750 "Liganded Gz-activating GPCR acts as a GEF for Gz, Xenopus tropicalis"
xref: Reactome:REACT_79783 "VAV2 is a GEF for Rho/Rac family kinases, Canis familiaris"
xref: Reactome:REACT_79862 "Gq activation by P2Y purinoceptor 1, Taeniopygia guttata"
xref: Reactome:REACT_80006 "VAV1 is a GEF for Rho/Rac family kinases, Mus musculus"
xref: Reactome:REACT_80507 "Gs activation by prostacyclin receptor, Bos taurus"
xref: Reactome:REACT_80641 "Activation of Rap1 by membrane-associated GEFs, Canis familiaris"
xref: Reactome:REACT_80694 "Liganded G12/13-activating GPCR acts as a GEF for G12/13, Mus musculus"
xref: Reactome:REACT_80807 "VAV3 is a GEF for Rho/Rac family kinases, Canis familiaris"
xref: Reactome:REACT_81349 "Liganded Gs-activating GPCR acts as a GEF for Gs, Canis familiaris"
xref: Reactome:REACT_82067 "Gi activation by P2Y purinoceptor 12, Mus musculus"
xref: Reactome:REACT_82396 "Liganded Gi-activating GPCR acts as a GEF for Gi, Xenopus tropicalis"
xref: Reactome:REACT_82522 "Regeneration of eEF1A:GTP by eEF1B activity, Plasmodium falciparum"
xref: Reactome:REACT_82999 "(Frs2)C3G stimulates nucleotide exchange on Rap1, Canis familiaris"
xref: Reactome:REACT_83022 "p115-RhoGEF activation of Rac1, Sus scrofa"
xref: Reactome:REACT_83060 "Gs activation by prostacyclin receptor, Mus musculus"
xref: Reactome:REACT_83264 "VAV2 is a GEF for Rho/Rac family kinases, Sus scrofa"
xref: Reactome:REACT_83428 "Opsins that act as GEFs for G alpha-t, Xenopus tropicalis"
xref: Reactome:REACT_83544 "Activation of Rap1 by membrane-associated GEFs, Gallus gallus"
xref: Reactome:REACT_83699 "Activation of Gq by Muscarinic Acetylcholine Receptor M3, Rattus norvegicus"
xref: Reactome:REACT_84621 "Sar1p Activation And Membrane Binding, Arabidopsis thaliana"
xref: Reactome:REACT_85103 "VAV3 is a GEF for Rho/Rac family kinases, Bos taurus"
xref: Reactome:REACT_85579 "Activation of Cdc42 by pVav1, Sus scrofa"
xref: Reactome:REACT_85654 "Gq activation by TP receptor, Danio rerio"
xref: Reactome:REACT_85754 "VAV1 is a GEF for Rho/Rac family kinases, Drosophila melanogaster"
xref: Reactome:REACT_86122 "Activation of Rap1 by membrane-associated GEFs, Mus musculus"
xref: Reactome:REACT_86161 "p115-RhoGEF activation of Rac1, Rattus norvegicus"
xref: Reactome:REACT_86316 "p115-RhoGEF activation of Rac1, Mus musculus"
xref: Reactome:REACT_86337 "VAV3 is a GEF for Rho/Rac family kinases, Sus scrofa"
xref: Reactome:REACT_86600 "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11, Xenopus tropicalis"
xref: Reactome:REACT_86605 "G13 activation by TP receptor, Mus musculus"
xref: Reactome:REACT_86755 "G13 activation by TP receptor, Xenopus tropicalis"
xref: Reactome:REACT_87162 "VAV2 is a GEF for Rho/Rac family kinases, Xenopus tropicalis"
xref: Reactome:REACT_87376 "Activation of Rap1 by cytosolic GEFs, Danio rerio"
xref: Reactome:REACT_87420 "Activation of Rap1 by cytosolic GEFs, Canis familiaris"
xref: Reactome:REACT_87432 "C3G stimulates nucleotide exchange on Rap1, Danio rerio"
xref: Reactome:REACT_88322 "Gq activation by TP receptor, Taeniopygia guttata"
xref: Reactome:REACT_88390 "Activation of Gq by Fatty Acid Receptor 1: Fatty Acid Complex, Rattus norvegicus"
xref: Reactome:REACT_88466 "Liganded Gz-activating GPCR acts as a GEF for Gz, Danio rerio"
xref: Reactome:REACT_88628 "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor, Mus musculus"
xref: Reactome:REACT_88693 "VAV3 is a GEF for Rho/Rac family kinases, Danio rerio"
xref: Reactome:REACT_88712 "Gi activation by P2Y purinoceptor 12, Taeniopygia guttata"
xref: Reactome:REACT_88844 "Gi activation by P2Y purinoceptor 12, Sus scrofa"
xref: Reactome:REACT_88931 "Gi activation by P2Y purinoceptor 12, Danio rerio"
xref: Reactome:REACT_88989 "Opsins that act as GEFs for G alpha-t, Taeniopygia guttata"
xref: Reactome:REACT_89041 "Gs activation by prostacyclin receptor, Gallus gallus"
xref: Reactome:REACT_89183 "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11, Canis familiaris"
xref: Reactome:REACT_89187 "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor, Canis familiaris"
xref: Reactome:REACT_89508 "(Frs2)C3G stimulates nucleotide exchange on Rap1, Gallus gallus"
xref: Reactome:REACT_89638 "G13 activation by TP receptor, Bos taurus"
xref: Reactome:REACT_89812 "Activation of Rap1 by cytosolic GEFs, Taeniopygia guttata"
xref: Reactome:REACT_89832 "C3G stimulates nucleotide exchange on Rap1, Canis familiaris"
xref: Reactome:REACT_89894 "Activation of Rap1 by cytosolic GEFs, Sus scrofa"
xref: Reactome:REACT_90259 "Gs activation by prostacyclin receptor, Canis familiaris"
xref: Reactome:REACT_90547 "VAV1 is a GEF for Rho/Rac family kinases, Canis familiaris"
xref: Reactome:REACT_90621 "Activation of Gq by Fatty Acid Receptor 1: Fatty Acid Complex, Mus musculus"
xref: Reactome:REACT_90735 "Activation of Gq by Muscarinic Acetylcholine Receptor M3, Bos taurus"
xref: Reactome:REACT_90851 "Gq activation by TP receptor, Bos taurus"
xref: Reactome:REACT_90883 "G13 activation by TP receptor, Gallus gallus"
xref: Reactome:REACT_90952 "Liganded Gz-activating GPCR acts as a GEF for Gz, Sus scrofa"
xref: Reactome:REACT_90957 "VAV3 is a GEF for Rho/Rac family kinases, Gallus gallus"
xref: Reactome:REACT_90972 "VAV3 is a GEF for Rho/Rac family kinases, Caenorhabditis elegans"
xref: Reactome:REACT_91040 "Gq activation by P2Y purinoceptor 1, Bos taurus"
xref: Reactome:REACT_91047 "VAV2 is a GEF for Rho/Rac family kinases, Danio rerio"
xref: Reactome:REACT_91400 "Activation of Cdc42 by pVav1, Mus musculus"
xref: Reactome:REACT_91460 "Activation of Rap1 by cytosolic GEFs, Caenorhabditis elegans"
xref: Reactome:REACT_91485 "Activation of Cdc42 by pVav1, Taeniopygia guttata"
xref: Reactome:REACT_91527 "Activation of Gq by Muscarinic Acetylcholine Receptor M3, Canis familiaris"
xref: Reactome:REACT_91561 "Gq activation by TP receptor, Sus scrofa"
xref: Reactome:REACT_92090 "Activation of Rac1 by pVav1, Xenopus tropicalis"
xref: Reactome:REACT_92296 "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor, Taeniopygia guttata"
xref: Reactome:REACT_92362 "Activation of Gq by Fatty Acid Receptor 1: Fatty Acid Complex, Xenopus tropicalis"
xref: Reactome:REACT_92743 "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11, Bos taurus"
xref: Reactome:REACT_92880 "Liganded Gi-activating GPCR acts as a GEF for Gi, Canis familiaris"
xref: Reactome:REACT_93072 "Gq activation by P2Y purinoceptor 1, Mus musculus"
xref: Reactome:REACT_93077 "Sar1p Activation And Membrane Binding, Mus musculus"
xref: Reactome:REACT_93108 "Activation of Rac1 by pVav1, Mus musculus"
xref: Reactome:REACT_93352 "G13 activation by TP receptor, Canis familiaris"
xref: Reactome:REACT_93442 "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor, Xenopus tropicalis"
xref: Reactome:REACT_93643 "C3G stimulates nucleotide exchange on Rap1, Mus musculus"
xref: Reactome:REACT_93708 "Gq activation by TP receptor, Rattus norvegicus"
xref: Reactome:REACT_93824 "(Frs2)C3G stimulates nucleotide exchange on Rap1, Sus scrofa"
xref: Reactome:REACT_93888 "C3G stimulates nucleotide exchange on Rap1, Taeniopygia guttata"
xref: Reactome:REACT_93898 "p115-RhoGEF activation of Rac1, Danio rerio"
xref: Reactome:REACT_93925 "Liganded G12/13-activating GPCR acts as a GEF for G12/13, Gallus gallus"
xref: Reactome:REACT_94029 "Activation of Rap1 by cytosolic GEFs, Rattus norvegicus"
xref: Reactome:REACT_94065 "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11, Taeniopygia guttata"
xref: Reactome:REACT_94237 "VAV3 is a GEF for Rho/Rac family kinases, Mus musculus"
xref: Reactome:REACT_94277 "Gi activation by P2Y purinoceptor 12, Xenopus tropicalis"
xref: Reactome:REACT_94454 "(Frs2)C3G stimulates nucleotide exchange on Rap1, Taeniopygia guttata"
xref: Reactome:REACT_94569 "VAV2 is a GEF for Rho/Rac family kinases, Drosophila melanogaster"
xref: Reactome:REACT_94684 "Activation of Rap1 by membrane-associated GEFs, Danio rerio"
xref: Reactome:REACT_94737 "Gq activation by P2Y purinoceptor 1, Canis familiaris"
xref: Reactome:REACT_94953 "VAV1 is a GEF for Rho/Rac family kinases, Sus scrofa"
xref: Reactome:REACT_95254 "Liganded G12/13-activating GPCR acts as a GEF for G12/13, Danio rerio"
xref: Reactome:REACT_95591 "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor, Rattus norvegicus"
xref: Reactome:REACT_96016 "Activation of Gq by Muscarinic Acetylcholine Receptor M3, Taeniopygia guttata"
xref: Reactome:REACT_96673 "Activation of Cdc42 by pVav1, Gallus gallus"
xref: Reactome:REACT_96836 "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor, Danio rerio"
xref: Reactome:REACT_96942 "Liganded G12/13-activating GPCR acts as a GEF for G12/13, Rattus norvegicus"
xref: Reactome:REACT_97040 "Activation of Rap1 by membrane-associated GEFs, Taeniopygia guttata"
xref: Reactome:REACT_97508 "Activation of Rap1 by cytosolic GEFs, Gallus gallus"
xref: Reactome:REACT_97558 "Regeneration of eEF1A:GTP by eEF1B activity, Danio rerio"
xref: Reactome:REACT_97631 "Liganded Gs-activating GPCR acts as a GEF for Gs, Bos taurus"
xref: Reactome:REACT_97694 "C3G stimulates nucleotide exchange on Rap1, Xenopus tropicalis"
xref: Reactome:REACT_97921 "Activation of Rap1 by membrane-associated GEFs, Xenopus tropicalis"
xref: Reactome:REACT_97991 "Gq activation by P2Y purinoceptor 1, Sus scrofa"
xref: Reactome:REACT_98174 "VAV2 is a GEF for Rho/Rac family kinases, Mus musculus"
xref: Reactome:REACT_98386 "Gs activation by prostacyclin receptor, Xenopus tropicalis"
xref: Reactome:REACT_98453 "Gq activation by P2Y purinoceptor 1, Gallus gallus"
xref: Reactome:REACT_98827 "VAV2 is a GEF for Rho/Rac family kinases, Rattus norvegicus"
xref: Reactome:REACT_99149 "Sar1p Activation And Membrane Binding, Drosophila melanogaster"
xref: Reactome:REACT_99303 "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11, Danio rerio"
is_a: GO:0098772 ! molecular function regulator
relationship: negatively_regulates GO:0019003 ! GDP binding
relationship: part_of GO:0043547 ! positive regulation of GTPase activity

[Term]
id: GO:0005086
name: ARF guanyl-nucleotide exchange factor activity
namespace: molecular_function
def: "Stimulates the exchange of guanyl nucleotides associated with the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
xref: Reactome:REACT_100970 "trans-Golgi Network Coat Activation, Drosophila melanogaster"
xref: Reactome:REACT_101570 "trans-Golgi Network Coat Activation, Caenorhabditis elegans"
xref: Reactome:REACT_101695 "trans-Golgi Network Coat Activation, Canis familiaris"
xref: Reactome:REACT_101742 "trans-Golgi Network Coat Activation, Arabidopsis thaliana"
xref: Reactome:REACT_101850 "Arf1 Activation by GBF1, Arabidopsis thaliana"
xref: Reactome:REACT_101990 "trans-Golgi Network Coat Activation, Rattus norvegicus"
xref: Reactome:REACT_102785 "trans-Golgi Network Coat Activation, Taeniopygia guttata"
xref: Reactome:REACT_105642 "Arf1 Activation by GBF1, Gallus gallus"
xref: Reactome:REACT_106445 "trans-Golgi Network Coat Activation, Gallus gallus"
xref: Reactome:REACT_109563 "trans-Golgi Network Coat Activation, Oryza sativa"
xref: Reactome:REACT_11099 "Arf1 Activation by GBF1, Homo sapiens"
xref: Reactome:REACT_14808 "trans-Golgi Network Coat Activation, Homo sapiens"
xref: Reactome:REACT_31480 "trans-Golgi Network Coat Activation, Bos taurus"
xref: Reactome:REACT_31752 "Arf1 Activation by GBF1, Xenopus tropicalis"
xref: Reactome:REACT_32323 "trans-Golgi Network Coat Activation, Mus musculus"
xref: Reactome:REACT_32544 "Arf1 Activation by GBF1, Oryza sativa"
xref: Reactome:REACT_34746 "trans-Golgi Network Coat Activation, Xenopus tropicalis"
xref: Reactome:REACT_77659 "Arf1 Activation by GBF1, Bos taurus"
xref: Reactome:REACT_80468 "Arf1 Activation by GBF1, Sus scrofa"
xref: Reactome:REACT_81977 "trans-Golgi Network Coat Activation, Schizosaccharomyces pombe"
xref: Reactome:REACT_86920 "Arf1 Activation by GBF1, Caenorhabditis elegans"
xref: Reactome:REACT_87319 "Arf1 Activation by GBF1, Drosophila melanogaster"
xref: Reactome:REACT_89002 "Arf1 Activation by GBF1, Danio rerio"
xref: Reactome:REACT_89142 "Arf1 Activation by GBF1, Taeniopygia guttata"
xref: Reactome:REACT_89319 "trans-Golgi Network Coat Activation, Danio rerio"
xref: Reactome:REACT_90559 "Arf1 Activation by GBF1, Rattus norvegicus"
xref: Reactome:REACT_90928 "Arf1 Activation by GBF1, Schizosaccharomyces pombe"
xref: Reactome:REACT_90936 "Arf1 Activation by GBF1, Canis familiaris"
xref: Reactome:REACT_98384 "trans-Golgi Network Coat Activation, Sus scrofa"
xref: Reactome:REACT_99473 "Arf1 Activation by GBF1, Mus musculus"
is_a: GO:0005085 ! guanyl-nucleotide exchange factor activity

[Term]
id: GO:0005087
name: Ran guanyl-nucleotide exchange factor activity
namespace: molecular_function
def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ran family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
synonym: "RCC1" EXACT []
xref: Reactome:REACT_9507 "Conversion of Ran-GDP to Ran-GTP, Homo sapiens"
xref: Wikipedia:RCC1
is_a: GO:0005088 ! Ras guanyl-nucleotide exchange factor activity

[Term]
id: GO:0005088
name: Ras guanyl-nucleotide exchange factor activity
namespace: molecular_function
def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
xref: Reactome:REACT_100245 "Activation of Rac by Sos, Danio rerio"
xref: Reactome:REACT_100798 "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras, Gallus gallus"
xref: Reactome:REACT_101653 "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1), Bos taurus"
xref: Reactome:REACT_102004 "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1), Danio rerio"
xref: Reactome:REACT_102156 "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1), Rattus norvegicus"
xref: Reactome:REACT_102326 "Activation of Rac by Sos, Gallus gallus"
xref: Reactome:REACT_102522 "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1), Gallus gallus"
xref: Reactome:REACT_103870 "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1), Rattus norvegicus"
xref: Reactome:REACT_103912 "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos), Xenopus tropicalis"
xref: Reactome:REACT_105014 "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos), Taeniopygia guttata"
xref: Reactome:REACT_106236 "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1), Taeniopygia guttata"
xref: Reactome:REACT_106903 "SOS mediated nucleotide exchange of RAS (SHC), Mus musculus"
xref: Reactome:REACT_108527 "SOS mediated nucleotide exchange of RAS (SHC), Bos taurus"
xref: Reactome:REACT_109002 "Sos-mediated nucleotide exchange of Ras (PDGF receptor:Grb2:Sos), Bos taurus"
xref: Reactome:REACT_110897 "Sos-mediated nucleotide exchange of Ras (PDGF receptor:Grb2:Sos), Canis familiaris"
xref: Reactome:REACT_110967 "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras, Drosophila melanogaster"
xref: Reactome:REACT_111091 "Activation of RAS by p-KIT bound SOS1, Homo sapiens"
xref: Reactome:REACT_111095 "Ras nucleotide exchange by GRB2:SOS1 through p-SHC, Homo sapiens"
xref: Reactome:REACT_111126 "Ras nucleotide exchange by GRB2:SOS1 bound to p-FRS2:activated FGFR, Homo sapiens"
xref: Reactome:REACT_115638 "Ras guanyl-nucleotide exchange mediated by Sos1 in complex with GRB2 and P-Erbb2mut, Homo sapiens"
xref: Reactome:REACT_115675 "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers, Homo sapiens"
xref: Reactome:REACT_115771 "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers., Homo sapiens"
xref: Reactome:REACT_115809 "SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFR mutants), Homo sapiens"
xref: Reactome:REACT_115858 "Ras guanyl-nucleotide exchange mediated by Sos1 bound to GRB2 in complex with P-Shc1:P-Erbb2mut, Homo sapiens"
xref: Reactome:REACT_115999 "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4, Homo sapiens"
xref: Reactome:REACT_116041 "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers, Homo sapiens"
xref: Reactome:REACT_116154 "SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFR mutants), Homo sapiens"
xref: Reactome:REACT_12386 "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1), Homo sapiens"
xref: Reactome:REACT_12402 "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1), Homo sapiens"
xref: Reactome:REACT_12516 "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos), Homo sapiens"
xref: Reactome:REACT_1672 "SOS mediated nucleotide exchange of RAS (IRS), Homo sapiens"
xref: Reactome:REACT_16923 "Sos-mediated nucleotide exchange of Ras (PDGF receptor:Grb2:Sos), Homo sapiens"
xref: Reactome:REACT_171 "SOS mediated nucleotide exchange of RAS (SHC), Rattus norvegicus"
xref: Reactome:REACT_18366 "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras, Homo sapiens"
xref: Reactome:REACT_19121 "Activation of Rac1 by FARP2, Mus musculus"
xref: Reactome:REACT_19252 "Activation of Rac by Sos, Homo sapiens"
xref: Reactome:REACT_19386 "Activation of Rac by Sos, Drosophila melanogaster"
xref: Reactome:REACT_2010 "SOS mediated nucleotide exchange of RAS (SHC), Homo sapiens"
xref: Reactome:REACT_20612 "Ras activation, Homo sapiens"
xref: Reactome:REACT_23928 "SOS1 activates H-Ras, Homo sapiens"
xref: Reactome:REACT_29830 "Sos-mediated nucleotide exchange of Ras (PDGF receptor:Grb2:Sos), Taeniopygia guttata"
xref: Reactome:REACT_30420 "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras, Danio rerio"
xref: Reactome:REACT_32023 "SOS mediated nucleotide exchange of RAS (IRS), Taeniopygia guttata"
xref: Reactome:REACT_32460 "SOS mediated nucleotide exchange of RAS (SHC), Danio rerio"
xref: Reactome:REACT_32668 "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos), Gallus gallus"
xref: Reactome:REACT_32844 "Sos-mediated nucleotide exchange of Ras (PDGF receptor:Grb2:Sos), Mus musculus"
xref: Reactome:REACT_33114 "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras, Sus scrofa"
xref: Reactome:REACT_33599 "Activation of Rac by Sos, Xenopus tropicalis"
xref: Reactome:REACT_34319 "SOS mediated nucleotide exchange of RAS (IRS), Sus scrofa"
xref: Reactome:REACT_77034 "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1), Gallus gallus"
xref: Reactome:REACT_77145 "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos), Mus musculus"
xref: Reactome:REACT_77492 "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos), Sus scrofa"
xref: Reactome:REACT_77575 "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1), Mus musculus"
xref: Reactome:REACT_79065 "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras, Xenopus tropicalis"
xref: Reactome:REACT_79439 "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1), Bos taurus"
xref: Reactome:REACT_79849 "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras, Rattus norvegicus"
xref: Reactome:REACT_80093 "Sos-mediated nucleotide exchange of Ras (PDGF receptor:Grb2:Sos), Danio rerio"
xref: Reactome:REACT_81289 "SOS mediated nucleotide exchange of RAS (SHC), Xenopus tropicalis"
xref: Reactome:REACT_81540 "SOS mediated nucleotide exchange of RAS (IRS), Gallus gallus"
xref: Reactome:REACT_81544 "SOS mediated nucleotide exchange of RAS (IRS), Danio rerio"
xref: Reactome:REACT_83053 "Activation of Rac by Sos, Bos taurus"
xref: Reactome:REACT_83578 "Activation of Rac by Sos, Mus musculus"
xref: Reactome:REACT_84985 "SOS mediated nucleotide exchange of RAS (SHC), Gallus gallus"
xref: Reactome:REACT_86235 "Activation of Rac by Sos, Canis familiaris"
xref: Reactome:REACT_86729 "Activation of Rac by Sos, Taeniopygia guttata"
xref: Reactome:REACT_87571 "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras, Bos taurus"
xref: Reactome:REACT_87691 "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1), Xenopus tropicalis"
xref: Reactome:REACT_88348 "Activation of Rac by Sos, Rattus norvegicus"
xref: Reactome:REACT_88657 "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1), Canis familiaris"
xref: Reactome:REACT_88743 "Sos-mediated nucleotide exchange of Ras (PDGF receptor:Grb2:Sos), Xenopus tropicalis"
xref: Reactome:REACT_88810 "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1), Mus musculus"
xref: Reactome:REACT_89197 "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras, Canis familiaris"
xref: Reactome:REACT_89518 "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras, Mus musculus"
xref: Reactome:REACT_89624 "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos), Canis familiaris"
xref: Reactome:REACT_90016 "SOS mediated nucleotide exchange of RAS (IRS), Xenopus tropicalis"
xref: Reactome:REACT_911 "SOS mediated nucleotide exchange of RAS (IRS), Rattus norvegicus"
xref: Reactome:REACT_91864 "SOS mediated nucleotide exchange of RAS (IRS), Mus musculus"
xref: Reactome:REACT_91887 "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos), Bos taurus"
xref: Reactome:REACT_93477 "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1), Taeniopygia guttata"
xref: Reactome:REACT_93791 "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos), Rattus norvegicus"
xref: Reactome:REACT_94524 "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos), Danio rerio"
xref: Reactome:REACT_94650 "SOS mediated nucleotide exchange of RAS (IRS), Canis familiaris"
xref: Reactome:REACT_96087 "SOS mediated nucleotide exchange of RAS (SHC), Sus scrofa"
xref: Reactome:REACT_96781 "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1), Canis familiaris"
xref: Reactome:REACT_96883 "Sos-mediated nucleotide exchange of Ras (PDGF receptor:Grb2:Sos), Sus scrofa"
xref: Reactome:REACT_97091 "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras, Taeniopygia guttata"
xref: Reactome:REACT_97247 "SOS mediated nucleotide exchange of RAS (SHC), Taeniopygia guttata"
xref: Reactome:REACT_97461 "Sos-mediated nucleotide exchange of Ras (PDGF receptor:Grb2:Sos), Rattus norvegicus"
xref: Reactome:REACT_97468 "Sos-mediated nucleotide exchange of Ras (PDGF receptor:Grb2:Sos), Gallus gallus"
xref: Reactome:REACT_98264 "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1), Danio rerio"
xref: Reactome:REACT_98577 "SOS mediated nucleotide exchange of RAS (SHC), Canis familiaris"
xref: Reactome:REACT_98780 "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1), Xenopus tropicalis"
xref: Reactome:REACT_99489 "SOS mediated nucleotide exchange of RAS (IRS), Bos taurus"
is_a: GO:0005085 ! guanyl-nucleotide exchange factor activity

[Term]
id: GO:0005089
name: Rho guanyl-nucleotide exchange factor activity
namespace: molecular_function
def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
subset: goslim_chembl
synonym: "Rho guanine nucleotide exchange factor" EXACT []
synonym: "RhoGEF" EXACT []
xref: Reactome:REACT_100152 "Activation of Rac1, Xenopus tropicalis"
xref: Reactome:REACT_100689 "Activation of Rho by LARG and PDZ-RhoGEF, Sus scrofa"
xref: Reactome:REACT_100721 "GEFs activate Rho GTPase:GDP, Schizosaccharomyces pombe"
xref: Reactome:REACT_10098 "GEFs activate Rho GTPase:GDP, Homo sapiens"
xref: Reactome:REACT_100998 "Activation of Cdc42, Caenorhabditis elegans"
xref: Reactome:REACT_101393 "GEFs activate RhoA,B,C, Mus musculus"
xref: Reactome:REACT_103139 "Activation of Rho by LARG and PDZ-RhoGEF, Rattus norvegicus"
xref: Reactome:REACT_103592 "GEFs activate Rho GTPase:GDP, Caenorhabditis elegans"
xref: Reactome:REACT_103724 "Activation of Cdc42, Bos taurus"
xref: Reactome:REACT_105214 "Activation of Cdc42, Rattus norvegicus"
xref: Reactome:REACT_105608 "GEFs activate RhoA,B,C, Canis familiaris"
xref: Reactome:REACT_106134 "GEFs activate RhoA,B,C, Dictyostelium discoideum"
xref: Reactome:REACT_108126 "GEFs activate RhoA,B,C, Gallus gallus"
xref: Reactome:REACT_108320 "Activation of Rho by LARG and PDZ-RhoGEF, Xenopus tropicalis"
xref: Reactome:REACT_108721 "GEFs activate Rho GTPase:GDP, Mus musculus"
xref: Reactome:REACT_108759 "Activation of Rho by LARG and PDZ-RhoGEF, Mus musculus"
xref: Reactome:REACT_109052 "GEFs activate Rho GTPase:GDP, Danio rerio"
xref: Reactome:REACT_109265 "RhoA is activated by nucleotide exchange and inhibits axonal growth, Caenorhabditis elegans"
xref: Reactome:REACT_109689 "GEFs activate RhoA,B,C, Rattus norvegicus"
xref: Reactome:REACT_112014 "RhoA is activated by nucleotide exchange and inhibits axonal growth, Danio rerio"
xref: Reactome:REACT_114452 "RhoA is activated by nucleotide exchange and inhibits axonal growth, Xenopus tropicalis"
xref: Reactome:REACT_114487 "RhoA is activated by nucleotide exchange and inhibits axonal growth, Rattus norvegicus"
xref: Reactome:REACT_13808 "RhoA is activated by nucleotide exchange and inhibits axonal growth, Homo sapiens"
xref: Reactome:REACT_19137 "Activation of Rho by LARG and PDZ-RhoGEF, Homo sapiens"
xref: Reactome:REACT_19216 "GEFs activate RhoA,B,C, Homo sapiens"
xref: Reactome:REACT_22200 "Activation of Rac1, Homo sapiens"
xref: Reactome:REACT_22281 "Activation of Cdc42, Homo sapiens"
xref: Reactome:REACT_28825 "Activation of Rho by LARG and PDZ-RhoGEF, Gallus gallus"
xref: Reactome:REACT_28967 "GEFs activate Rho GTPase:GDP, Sus scrofa"
xref: Reactome:REACT_30773 "GEFs activate Rho GTPase:GDP, Saccharomyces cerevisiae"
xref: Reactome:REACT_30791 "RhoA is activated by nucleotide exchange and inhibits axonal growth, Canis familiaris"
xref: Reactome:REACT_31433 "GEFs activate RhoA,B,C, Xenopus tropicalis"
xref: Reactome:REACT_31965 "Activation of Rac1, Rattus norvegicus"
xref: Reactome:REACT_32024 "Activation of Rho by LARG and PDZ-RhoGEF, Bos taurus"
xref: Reactome:REACT_32371 "GEFs activate Rho GTPase:GDP, Dictyostelium discoideum"
xref: Reactome:REACT_34520 "Activation of Rac1, Mus musculus"
xref: Reactome:REACT_77383 "GEFs activate RhoA,B,C, Bos taurus"
xref: Reactome:REACT_77389 "GEFs activate RhoA,B,C, Sus scrofa"
xref: Reactome:REACT_77531 "GEFs activate Rho GTPase:GDP, Oryza sativa"
xref: Reactome:REACT_79833 "GEFs activate Rho GTPase:GDP, Rattus norvegicus"
xref: Reactome:REACT_81313 "Activation of Rho by LARG and PDZ-RhoGEF, Danio rerio"
xref: Reactome:REACT_82885 "Activation of Rho by LARG and PDZ-RhoGEF, Taeniopygia guttata"
xref: Reactome:REACT_82970 "GEFs activate Rho GTPase:GDP, Taeniopygia guttata"
xref: Reactome:REACT_84523 "Activation of Cdc42, Mus musculus"
xref: Reactome:REACT_85048 "GEFs activate RhoA,B,C, Taeniopygia guttata"
xref: Reactome:REACT_86070 "GEFs activate RhoA,B,C, Caenorhabditis elegans"
xref: Reactome:REACT_87646 "GEFs activate Rho GTPase:GDP, Xenopus tropicalis"
xref: Reactome:REACT_88315 "GEFs activate Rho GTPase:GDP, Bos taurus"
xref: Reactome:REACT_91703 "GEFs activate Rho GTPase:GDP, Canis familiaris"
xref: Reactome:REACT_92249 "Activation of Rac1, Canis familiaris"
xref: Reactome:REACT_92606 "Activation of Cdc42, Danio rerio"
xref: Reactome:REACT_92645 "GEFs activate Rho GTPase:GDP, Drosophila melanogaster"
xref: Reactome:REACT_93562 "Activation of Cdc42, Xenopus tropicalis"
xref: Reactome:REACT_94383 "GEFs activate RhoA,B,C, Danio rerio"
xref: Reactome:REACT_94512 "GEFs activate RhoA,B,C, Drosophila melanogaster"
xref: Reactome:REACT_95084 "GEFs activate RhoA,B,C, Saccharomyces cerevisiae"
xref: Reactome:REACT_95178 "GEFs activate RhoA,B,C, Schizosaccharomyces pombe"
xref: Reactome:REACT_95796 "Activation of Rac1, Danio rerio"
xref: Reactome:REACT_96171 "Activation of Rac1, Drosophila melanogaster"
xref: Reactome:REACT_96181 "Activation of Cdc42, Sus scrofa"
xref: Reactome:REACT_96227 "GEFs activate Rho GTPase:GDP, Arabidopsis thaliana"
xref: Reactome:REACT_96803 "Activation of Rho by LARG and PDZ-RhoGEF, Canis familiaris"
xref: Reactome:REACT_97069 "Activation of Rac1, Bos taurus"
xref: Reactome:REACT_97117 "Activation of Cdc42, Drosophila melanogaster"
xref: Reactome:REACT_97788 "RhoA is activated by nucleotide exchange and inhibits axonal growth, Bos taurus"
xref: Reactome:REACT_98631 "RhoA is activated by nucleotide exchange and inhibits axonal growth, Drosophila melanogaster"
xref: Reactome:REACT_98998 "GEFs activate Rho GTPase:GDP, Gallus gallus"
xref: Reactome:REACT_99425 "RhoA is activated by nucleotide exchange and inhibits axonal growth, Mus musculus"
is_a: GO:0005088 ! Ras guanyl-nucleotide exchange factor activity

[Term]
id: GO:0005090
name: Sar guanyl-nucleotide exchange factor activity
namespace: molecular_function
def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Sar family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
comment: Note that the name Sar derives from 'secretion-associated, Ras-related'.
is_a: GO:0005085 ! guanyl-nucleotide exchange factor activity
is_a: GO:0030695 ! GTPase regulator activity

[Term]
id: GO:0005091
name: guanyl-nucleotide exchange factor adaptor activity
namespace: molecular_function
def: "The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other proteins, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw]
is_a: GO:0030674 ! protein binding, bridging
is_a: GO:0030695 ! GTPase regulator activity

[Term]
id: GO:0005092
name: GDP-dissociation inhibitor activity
namespace: molecular_function
def: "Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding." [GOC:mah]
synonym: "GDI" EXACT []
is_a: GO:0030695 ! GTPase regulator activity
relationship: positively_regulates GO:0019003 ! GDP binding

[Term]
id: GO:0005093
name: Rab GDP-dissociation inhibitor activity
namespace: molecular_function
def: "Prevents the dissociation of GDP from the small GTPase Rab, thereby preventing GTP from binding." [GOC:mah]
is_a: GO:0005092 ! GDP-dissociation inhibitor activity

[Term]
id: GO:0005094
name: Rho GDP-dissociation inhibitor activity
namespace: molecular_function
def: "Prevents the dissociation of GDP from the small GTPase Rho, thereby preventing GTP from binding." [GOC:mah]
is_a: GO:0005092 ! GDP-dissociation inhibitor activity

[Term]
id: GO:0005095
name: GTPase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of GTP to GDP and orthophosphate." [GOC:ai]
synonym: "GIP" BROAD []
is_a: GO:0004857 ! enzyme inhibitor activity
is_a: GO:0030695 ! GTPase regulator activity
relationship: negatively_regulates GO:0003924 ! GTPase activity
relationship: part_of GO:0034260 ! negative regulation of GTPase activity

[Term]
id: GO:0005096
name: GTPase activator activity
namespace: molecular_function
alt_id: GO:0005097
alt_id: GO:0005098
alt_id: GO:0005099
alt_id: GO:0005100
alt_id: GO:0005101
alt_id: GO:0008060
alt_id: GO:0017123
alt_id: GO:0030675
alt_id: GO:0046582
def: "Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
comment: Note that the name Sar derives from 'secretion-associated, Ras-related'.
subset: gosubset_prok
synonym: "ARF GAP activity" NARROW [GOC:pg]
synonym: "ARF GTPase activator activity" NARROW []
synonym: "GAP activity" EXACT []
synonym: "Rab GAP activity" NARROW [GOC:pg]
synonym: "Rab GTPase activator activity" NARROW []
synonym: "Rac GAP activity" NARROW [GOC:pg]
synonym: "Rac GTPase activator activity" NARROW []
synonym: "Ral GAP activity" NARROW [GOC:pg]
synonym: "Ral GTPase activator activity" NARROW []
synonym: "Ran GAP activity" NARROW [GOC:pg]
synonym: "Ran GTPase activator activity" NARROW []
synonym: "RanGAP" NARROW []
synonym: "Rap GAP activity" NARROW [GOC:pg]
synonym: "Rap GTPase activator activity" NARROW []
synonym: "Ras GAP activity" NARROW [GOC:pg]
synonym: "Ras GTPase activator activity" NARROW []
synonym: "Rho GAP activity" NARROW [GOC:pg]
synonym: "Rho GTPase activator activity" NARROW []
synonym: "Sar GAP activity" NARROW [GOC:pg]
synonym: "Sar GTPase activator activity" NARROW []
xref: Reactome:REACT_100037 "Hydrolysis of Arf1-GTP to Arf1-GDP, Schizosaccharomyces pombe"
xref: Reactome:REACT_100399 "Rap1 signal termination by Rap1GAPs, Mus musculus"
xref: Reactome:REACT_100517 "TSC2 activates intrinsic GTPase activity of Rheb, Danio rerio"
xref: Reactome:REACT_101790 "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity, Sus scrofa"
xref: Reactome:REACT_102733 "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity, Mus musculus"
xref: Reactome:REACT_103137 "Hydrolysis of Arf1-GTP to Arf1-GDP, Rattus norvegicus"
xref: Reactome:REACT_103891 "GAPs inactivate Rho GTPase:GTP by hydrolysis, Arabidopsis thaliana"
xref: Reactome:REACT_104735 "GAPs inactivate Rho GTPase:GTP by hydrolysis, Xenopus tropicalis"
xref: Reactome:REACT_105046 "Hydrolysis of Arf1-GTP to Arf1-GDP, Canis familiaris"
xref: Reactome:REACT_105205 "TSC2 activates intrinsic GTPase activity of Rheb, Bos taurus"
xref: Reactome:REACT_105880 "Inactivation of Rho-GTP by p190RhoGAP, Xenopus tropicalis"
xref: Reactome:REACT_106102 "Inactivation of Cdc42, Sus scrofa"
xref: Reactome:REACT_106107 "Inactivation of Cdc42, Caenorhabditis elegans"
xref: Reactome:REACT_106167 "Rap1 signal termination by Rap1GAPs, Caenorhabditis elegans"
xref: Reactome:REACT_107460 "TSC2 activates intrinsic GTPase activity of Rheb, Mus musculus"
xref: Reactome:REACT_107555 "Inactivation of R-Ras by Sema3A-Plexin-A GAP activity, Danio rerio"
xref: Reactome:REACT_109556 "TSC2 activates intrinsic GTPase activity of Rheb, Sus scrofa"
xref: Reactome:REACT_110213 "GAPs inactivate Rho GTPase:GTP by hydrolysis, Dictyostelium discoideum"
xref: Reactome:REACT_110672 "Hydrolysis of Arf1-GTP to Arf1-GDP, Mus musculus"
xref: Reactome:REACT_110956 "Inactivation of R-Ras by Sema3A-Plexin-A GAP activity, Rattus norvegicus"
xref: Reactome:REACT_11107 "Hydrolysis of Arf1-GTP to Arf1-GDP, Homo sapiens"
xref: Reactome:REACT_112033 "Hydrolysis of Arf1-GTP to Arf1-GDP, Saccharomyces cerevisiae"
xref: Reactome:REACT_114368 "Inactivation of Rho-GTP by p190RhoGAP, Danio rerio"
xref: Reactome:REACT_115083 "Inactivation of R-Ras by Sema3A-Plexin-A GAP activity, Xenopus tropicalis"
xref: Reactome:REACT_115214 "Inactivation of Rho-GTP by p190RhoGAP, Rattus norvegicus"
xref: Reactome:REACT_115497 "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity, Xenopus tropicalis"
xref: Reactome:REACT_19117 "Inactivation of R-Ras by Sema3A-Plexin-A GAP activity, Homo sapiens"
xref: Reactome:REACT_19120 "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity, Homo sapiens"
xref: Reactome:REACT_19125 "Inactivation of Cdc42, Homo sapiens"
xref: Reactome:REACT_19181 "Inactivation of R-Ras by Sema3A-Plexin-A1 GAP activity, Mus musculus"
xref: Reactome:REACT_19204 "Inactivation of Cdc42, Rattus norvegicus"
xref: Reactome:REACT_19242 "Inactivation of Rho-GTP by p190RhoGAP, Homo sapiens"
xref: Reactome:REACT_19359 "Inactivation of Rac1, Homo sapiens"
xref: Reactome:REACT_19409 "Inactivation of Rac1, Drosophila melanogaster"
xref: Reactome:REACT_21261 "TSC2 activates intrinsic GTPase activity of Rheb, Homo sapiens"
xref: Reactome:REACT_23811 "Rap1 signal termination by Rap1GAPs, Homo sapiens"
xref: Reactome:REACT_28434 "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity, Rattus norvegicus"
xref: Reactome:REACT_29133 "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity, Danio rerio"
xref: Reactome:REACT_29594 "GAPs inactivate Rho GTPase:GTP by hydrolysis, Oryza sativa"
xref: Reactome:REACT_29936 "GAPs inactivate Rho GTPase:GTP by hydrolysis, Schizosaccharomyces pombe"
xref: Reactome:REACT_30412 "GAPs inactivate Rho GTPase:GTP by hydrolysis, Drosophila melanogaster"
xref: Reactome:REACT_30771 "Inactivation of Rac1, Mus musculus"
xref: Reactome:REACT_31216 "Inactivation of Cdc42, Gallus gallus"
xref: Reactome:REACT_31467 "TSC2 activates intrinsic GTPase activity of Rheb, Xenopus tropicalis"
xref: Reactome:REACT_32029 "GAPs inactivate Rho GTPase:GTP by hydrolysis, Sus scrofa"
xref: Reactome:REACT_32249 "Rap1 signal termination by Rap1GAPs, Gallus gallus"
xref: Reactome:REACT_32397 "GAPs inactivate Rho GTPase:GTP by hydrolysis, Rattus norvegicus"
xref: Reactome:REACT_32553 "Inactivation of Cdc42, Danio rerio"
xref: Reactome:REACT_32773 "Inactivation of Rac1, Bos taurus"
xref: Reactome:REACT_34038 "GAPs inactivate Rho GTPase:GTP by hydrolysis, Canis familiaris"
xref: Reactome:REACT_39687 "Hydrolysis of Arf1-GTP to Arf1-GDP, Caenorhabditis elegans"
xref: Reactome:REACT_6328 "DRheb is inhibited by the TSC1/2 complex, Drosophila melanogaster"
xref: Reactome:REACT_77384 "Rap1 signal termination by Rap1GAPs, Canis familiaris"
xref: Reactome:REACT_77579 "Hydrolysis of Arf1-GTP to Arf1-GDP, Plasmodium falciparum"
xref: Reactome:REACT_79015 "GAPs inactivate Rho GTPase:GTP by hydrolysis, Caenorhabditis elegans"
xref: Reactome:REACT_79166 "Inactivation of Rac1, Taeniopygia guttata"
xref: Reactome:REACT_79350 "GAPs inactivate Rho GTPase:GTP by hydrolysis, Saccharomyces cerevisiae"
xref: Reactome:REACT_79491 "Hydrolysis of Arf1-GTP to Arf1-GDP, Taeniopygia guttata"
xref: Reactome:REACT_79580 "Inactivation of Rho-GTP by p190RhoGAP, Taeniopygia guttata"
xref: Reactome:REACT_81264 "Rap1 signal termination by Rap1GAPs, Rattus norvegicus"
xref: Reactome:REACT_81375 "Hydrolysis of Arf1-GTP to Arf1-GDP, Xenopus tropicalis"
xref: Reactome:REACT_81710 "Inactivation of R-Ras by Sema3A-Plexin-A GAP activity, Canis familiaris"
xref: Reactome:REACT_82254 "GAPs inactivate Rho GTPase:GTP by hydrolysis, Bos taurus"
xref: Reactome:REACT_82277 "Inactivation of R-Ras by Sema3A-Plexin-A GAP activity, Bos taurus"
xref: Reactome:REACT_83101 "GAPs inactivate Rho GTPase:GTP by hydrolysis, Danio rerio"
xref: Reactome:REACT_83421 "GAPs inactivate Rho GTPase:GTP by hydrolysis, Gallus gallus"
xref: Reactome:REACT_83638 "TSC2 activates intrinsic GTPase activity of Rheb, Drosophila melanogaster"
xref: Reactome:REACT_83910 "Hydrolysis of Arf1-GTP to Arf1-GDP, Danio rerio"
xref: Reactome:REACT_84528 "Inactivation of Rac1, Rattus norvegicus"
xref: Reactome:REACT_85155 "Inactivation of Cdc42, Mus musculus"
xref: Reactome:REACT_85340 "Rap1 signal termination by Rap1GAPs, Taeniopygia guttata"
xref: Reactome:REACT_85789 "Hydrolysis of Arf1-GTP to Arf1-GDP, Dictyostelium discoideum"
xref: Reactome:REACT_86052 "Inactivation of R-Ras by Sema3A-Plexin-A GAP activity, Sus scrofa"
xref: Reactome:REACT_86081 "GAPs inactivate Rho GTPase:GTP by hydrolysis, Mus musculus"
xref: Reactome:REACT_86314 "Inactivation of Rho-GTP by p190RhoGAP, Bos taurus"
xref: Reactome:REACT_87017 "Hydrolysis of Arf1-GTP to Arf1-GDP, Bos taurus"
xref: Reactome:REACT_87209 "Inactivation of Rac1, Gallus gallus"
xref: Reactome:REACT_87601 "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity, Bos taurus"
xref: Reactome:REACT_87851 "Inactivation of Rho-GTP by p190RhoGAP, Gallus gallus"
xref: Reactome:REACT_88542 "Inactivation of Rac1, Danio rerio"
xref: Reactome:REACT_89490 "Inactivation of Rho-GTP by p190RhoGAP, Mus musculus"
xref: Reactome:REACT_89520 "Hydrolysis of Arf1-GTP to Arf1-GDP, Drosophila melanogaster"
xref: Reactome:REACT_89620 "Rap1 signal termination by Rap1GAPs, Drosophila melanogaster"
xref: Reactome:REACT_89858 "Inactivation of Rac1, Canis familiaris"
xref: Reactome:REACT_91546 "Rap1 signal termination by Rap1GAPs, Dictyostelium discoideum"
xref: Reactome:REACT_91668 "TSC2 activates intrinsic GTPase activity of Rheb, Canis familiaris"
xref: Reactome:REACT_92264 "TSC2 activates intrinsic GTPase activity of Rheb, Gallus gallus"
xref: Reactome:REACT_92625 "Rap1 signal termination by Rap1GAPs, Xenopus tropicalis"
xref: Reactome:REACT_93021 "TSC2 activates intrinsic GTPase activity of Rheb, Taeniopygia guttata"
xref: Reactome:REACT_94710 "Rap1 signal termination by Rap1GAPs, Danio rerio"
xref: Reactome:REACT_95100 "GAPs inactivate Rho GTPase:GTP by hydrolysis, Taeniopygia guttata"
xref: Reactome:REACT_95502 "Inactivation of Cdc42, Bos taurus"
xref: Reactome:REACT_95518 "Inactivation of Rho-GTP by p190RhoGAP, Canis familiaris"
xref: Reactome:REACT_95889 "Hydrolysis of Arf1-GTP to Arf1-GDP, Gallus gallus"
xref: Reactome:REACT_96614 "Inactivation of Rac1, Xenopus tropicalis"
xref: Reactome:REACT_96925 "Inactivation of Cdc42, Xenopus tropicalis"
xref: Reactome:REACT_97055 "Inactivation of Cdc42, Taeniopygia guttata"
xref: Reactome:REACT_97605 "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity, Canis familiaris"
xref: Reactome:REACT_97802 "Rap1 signal termination by Rap1GAPs, Sus scrofa"
xref: Reactome:REACT_98275 "Rap1 signal termination by Rap1GAPs, Bos taurus"
xref: Reactome:REACT_9982 "GAPs inactivate Rho GTPase:GTP by hydrolysis, Homo sapiens"
is_a: GO:0008047 ! enzyme activator activity
is_a: GO:0030695 ! GTPase regulator activity
relationship: part_of GO:0043547 ! positive regulation of GTPase activity
relationship: positively_regulates GO:0003924 ! GTPase activity

[Term]
id: GO:0005102
name: receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]
subset: goslim_chembl
subset: goslim_metagenomics
subset: goslim_plant
subset: gosubset_prok
synonym: "receptor ligand" NARROW []
synonym: "receptor-associated protein activity" RELATED []
xref: Wikipedia:Ligand_(biochemistry)
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0005104
name: fibroblast growth factor receptor binding
namespace: molecular_function
alt_id: GO:0001521
alt_id: GO:0005162
def: "Interacting selectively and non-covalently with the fibroblast growth factor receptor (FGFR)." [GOC:ceb]
comment: Note that branchless is the Drosophila gene encoding fibroblast growth factor.
synonym: "FGF receptor binding" EXACT []
synonym: "FGFR binding" EXACT []
synonym: "FGFR ligand" NARROW []
synonym: "fibroblast growth factor" BROAD []
synonym: "fibroblast growth factor receptor ligand" NARROW []
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0005105
name: type 1 fibroblast growth factor receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the type 1 fibroblast growth factor receptor (FGFR1)." [GOC:ceb, GOC:fb_curators]
comment: Note that breathless is the Drosophila gene encoding the type 1 fibroblast growth factor receptor (FGFR1).
synonym: "breathless binding" NARROW []
synonym: "breathless ligand" NARROW []
synonym: "FGFR1 binding" BROAD []
synonym: "FGFR1 ligand" NARROW []
synonym: "type 1 fibroblast growth factor receptor ligand" NARROW []
is_a: GO:0005104 ! fibroblast growth factor receptor binding

[Term]
id: GO:0005106
name: obsolete ephrin
namespace: molecular_function
def: "OBSOLETE. A class of proteins that interact with the ephrin receptors." [GOC:ai, ISBN:0198506732]
comment: This term was made obsolete because it refers to a class of gene products.
synonym: "ephrin" EXACT []
is_obsolete: true
consider: GO:0046875

[Term]
id: GO:0005107
name: obsolete GPI-linked ephrin
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it refers to a class of gene products.
synonym: "GPI-linked ephrin" EXACT []
is_obsolete: true
consider: GO:0046658
consider: GO:0046875

[Term]
id: GO:0005108
name: obsolete transmembrane ephrin
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it refers to a class of gene products.
synonym: "transmembrane ephrin" EXACT []
is_obsolete: true
consider: GO:0005887
consider: GO:0046875

[Term]
id: GO:0005109
name: frizzled binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the frizzled (fz) receptor." [GOC:ceb, PR:000001315]
subset: goslim_chembl
synonym: "frizzled ligand" NARROW []
synonym: "fz binding" EXACT []
synonym: "fz ligand" NARROW []
is_a: GO:0001664 ! G-protein coupled receptor binding

[Term]
id: GO:0005110
name: frizzled-2 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with frizzled-2 (fz2)." [GOC:ceb, PR:000007719]
synonym: "frizzled-2 ligand" NARROW []
synonym: "fz2 binding" EXACT []
synonym: "fz2 ligand" NARROW []
is_a: GO:0005109 ! frizzled binding

[Term]
id: GO:0005111
name: type 2 fibroblast growth factor receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the type 2 fibroblast growth factor receptor (FGFR2)." [GOC:fb_curators]
comment: Note that heartless is the Drosophila gene encoding the type 2 fibroblast growth factor receptor (FGFR2).
synonym: "FGFR2 binding" EXACT []
synonym: "FGFR2 ligand" NARROW []
synonym: "heartless binding" EXACT []
synonym: "heartless ligand" NARROW []
synonym: "type 2 fibroblast growth factor receptor ligand" NARROW []
is_a: GO:0005104 ! fibroblast growth factor receptor binding

[Term]
id: GO:0005112
name: Notch binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the Notch (N) protein, a surface receptor." [GOC:ceb]
synonym: "N binding" EXACT []
synonym: "N ligand" NARROW []
synonym: "Notch ligand" NARROW []
synonym: "Notch receptor binding" EXACT []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0005113
name: patched binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the patched (ptc) protein, a receptor for hedgehog proteins." [GOC:ceb, PMID:11731473]
synonym: "patched ligand" NARROW []
synonym: "ptc binding" EXACT []
synonym: "ptc ligand" NARROW []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0005114
name: type II transforming growth factor beta receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type II transforming growth factor beta receptor." [GOC:ceb, GOC:mah, PMID:11252892]
synonym: "punt binding" NARROW []
synonym: "punt ligand" NARROW []
synonym: "TGF-beta type II binding" EXACT []
synonym: "transforming growth factor beta ligand binding to type II receptor" RELATED []
synonym: "transforming growth factor beta receptor type II binding" EXACT []
synonym: "type II TGF-beta binding" EXACT []
is_a: GO:0005160 ! transforming growth factor beta receptor binding

[Term]
id: GO:0005115
name: receptor tyrosine kinase-like orphan receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the receptor tyrosine kinase-like orphan receptor (Ror)." [GOC:ceb, GOC:vw]
synonym: "receptor tyrosine kinase-like orphan receptor ligand" NARROW []
synonym: "Ror binding" BROAD []
synonym: "Ror ligand" RELATED []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0005117
name: wishful thinking binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with wishful thinking (Wit), a type II bone morphogenic protein receptor." [GOC:ceb, PMID:11856529]
synonym: "SE20 receptor binding" NARROW []
synonym: "wishful thinking ligand" NARROW []
synonym: "Wit binding" EXACT []
synonym: "Wit ligand" NARROW []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0005118
name: sevenless binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the sevenless (sev) protein, a receptor tyrosine kinase." [GOC:ceb, PMID:3151175]
synonym: "sev binding" EXACT []
synonym: "sev ligand" NARROW []
synonym: "sevenless ligand" NARROW []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0005119
name: smoothened binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the smoothened (smo) protein, which interacts with patched to transmit hedgehog signals." [GOC:ceb, PMID:11731473]
synonym: "smo binding" EXACT []
synonym: "smo ligand" NARROW []
synonym: "smoothened ligand" NARROW []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0005121
name: Toll binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the Toll protein, a transmembrane receptor." [GOC:ceb]
synonym: "Tl binding" EXACT []
synonym: "Toll ligand" NARROW []
synonym: "Toll receptor binding" EXACT []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0005122
name: torso binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the torso (tor) protein, a receptor tyrosine kinase." [GOC:ceb, PMID:2927509]
synonym: "tor binding" EXACT []
synonym: "tor ligand" NARROW []
synonym: "torso ligand" NARROW []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0005123
name: death receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any member of the death receptor (DR) family. The DR family falls within the tumor necrosis factor receptor superfamily and is characterized by a cytoplasmic region of ~80 residues termed the death domain (DD)." [GOC:ceb, GOC:rl, PMID:15654015]
subset: goslim_chembl
synonym: "APO binding" NARROW [GOC:rl]
synonym: "death receptor adaptor protein activity" RELATED []
synonym: "death receptor interacting protein activity" RELATED []
synonym: "death receptor ligand" NARROW []
synonym: "death receptor-associated factor activity" RELATED []
synonym: "DR binding" NARROW [GOC:rl]
synonym: "EDAR binding" NARROW [GOC:rl]
synonym: "FAS binding" NARROW [GOC:rl]
synonym: "KILLER binding" NARROW [GOC:rl]
synonym: "NGFR binding" NARROW [GOC:rl]
synonym: "TNFR1 binding" NARROW [GOC:rl]
synonym: "TRAIL binding" NARROW [GOC:rl]
is_a: GO:0032813 ! tumor necrosis factor receptor superfamily binding

[Term]
id: GO:0005124
name: scavenger receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with scavenger receptors, a family of proteins that are expressed on myeloid cells and are involved in the uptake of effete cellular components and foreign particles." [GOC:ceb]
synonym: "scavenger receptor ligand" NARROW []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0005125
name: cytokine activity
namespace: molecular_function
def: "Functions to control the survival, growth, differentiation and effector function of tissues and cells." [ISBN:0198599471]
subset: goslim_chembl
synonym: "autocrine activity" RELATED [GOC:rl]
synonym: "paracrine activity" RELATED [GOC:rl]
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0005126
name: cytokine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a cytokine receptor." [GOC:mah, GOC:vw]
synonym: "hematopoietin/interferon-class (D200-domain) cytokine receptor binding" EXACT [GOC:add, GOC:mah]
synonym: "hematopoietin/interferon-class (D200-domain) cytokine receptor ligand" NARROW []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0005127
name: ciliary neurotrophic factor receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the ciliary neurotrophic factor receptor." [GOC:ai]
synonym: "ciliary neurotrophic factor" NARROW []
synonym: "ciliary neurotrophic factor receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0005128
name: erythropoietin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the erythropoietin receptor." [GOC:ai]
synonym: "erythropoietin" NARROW []
synonym: "erythropoietin receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0005129
name: granulocyte macrophage colony-stimulating factor receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the granulocyte macrophage colony-stimulating factor receptor." [GOC:ai]
synonym: "GM-CSF receptor binding" EXACT [GOC:vk]
synonym: "GM-CSF receptor ligand" NARROW []
synonym: "GMC-SF receptor ligand" NARROW []
synonym: "granulocyte macrophage colony stimulating factor receptor binding" EXACT []
synonym: "granulocyte macrophage colony-stimulating factor" NARROW []
synonym: "granulocyte macrophage colony-stimulating factor receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0005130
name: granulocyte colony-stimulating factor receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the granulocyte colony-stimulating factor receptor." [GOC:ai]
synonym: "G-CSF receptor ligand" EXACT []
synonym: "GC-SF receptor ligand" EXACT []
synonym: "granulocyte colony stimulating factor receptor binding" EXACT []
synonym: "granulocyte colony-stimulating factor" NARROW []
synonym: "granulocyte colony-stimulating factor receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0005131
name: growth hormone receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the growth hormone receptor." [GOC:ai]
synonym: "growth hormone" NARROW []
synonym: "growth hormone receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding
is_a: GO:0051427 ! hormone receptor binding

[Term]
id: GO:0005132
name: type I interferon receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an interferon-type I receptor, a heterodimeric complex composed of an alpha subunit (IFNAR1) and a beta subunit (IFNAR2)." [GOC:ai, GOC:signaling, PMID:17502368]
synonym: "IFNAR binding" RELATED [PMID:17502368]
synonym: "IFNAR1 binding" NARROW [PR:000008922]
synonym: "IFNAR2 binding" NARROW [PR:000008923]
synonym: "interferon-alpha/beta" NARROW []
synonym: "interferon-alpha/beta receptor binding" EXACT [PR:000008922, PR:000008923]
synonym: "interferon-alpha/beta receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding
is_a: GO:0032403 ! protein complex binding

[Term]
id: GO:0005133
name: interferon-gamma receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interferon-gamma receptor." [GOC:ai]
synonym: "interferon-gamma" NARROW []
synonym: "interferon-gamma receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0005134
name: interleukin-2 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-2 receptor." [GOC:ai]
synonym: "IL-2" NARROW []
synonym: "interleukin-2 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0005135
name: interleukin-3 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-3 receptor." [GOC:ai]
synonym: "IL-3" NARROW []
synonym: "interleukin-3 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0005136
name: interleukin-4 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-4 receptor." [GOC:ai]
synonym: "IL-4" NARROW []
synonym: "interleukin-4 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0005137
name: interleukin-5 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-5 receptor." [GOC:ai]
subset: goslim_chembl
synonym: "IL-5" NARROW []
synonym: "interleukin-5 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0005138
name: interleukin-6 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-6 receptor." [GOC:ai]
subset: goslim_chembl
synonym: "IL-6" NARROW []
synonym: "interleukin-6 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0005139
name: interleukin-7 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-7 receptor." [GOC:ai]
synonym: "IL-7" NARROW []
synonym: "interleukin-7 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0005140
name: interleukin-9 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-9 receptor." [GOC:ai]
synonym: "IL-9" NARROW []
synonym: "interleukin-9 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0005141
name: interleukin-10 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-10 receptor." [GOC:ai]
synonym: "IL-10" NARROW []
synonym: "interleukin-10 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0005142
name: interleukin-11 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-11 receptor." [GOC:ai]
synonym: "IL-11" NARROW []
synonym: "interleukin-11 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0005143
name: interleukin-12 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-12 receptor." [GOC:ai]
synonym: "IL-12" NARROW []
synonym: "interleukin-12 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0005144
name: interleukin-13 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-13 receptor." [GOC:ai]
synonym: "IL-13" NARROW []
synonym: "interleukin-13 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0005145
name: interleukin-14 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-14 receptor." [GOC:ai]
synonym: "IL-14" NARROW []
synonym: "interleukin-14 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0005146
name: leukemia inhibitory factor receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the leukemia inhibitory factor receptor." [GOC:ai]
synonym: "leukemia inhibitory factor" NARROW []
synonym: "leukemia inhibitory factor receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0005147
name: oncostatin-M receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the oncostatin-M receptor." [GOC:ai]
synonym: "oncostatin-M" NARROW []
synonym: "oncostatin-M receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0005148
name: prolactin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the prolactin receptor." [GOC:ai]
synonym: "prolactin" NARROW []
synonym: "prolactin receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0005149
name: interleukin-1 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-1 receptor." [GOC:go_curators]
synonym: "IL-1" NARROW []
synonym: "interleukin-1 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0005150
name: interleukin-1, Type I receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a Type I interleukin-1 receptor." [GOC:ai]
synonym: "IL-1 type I" NARROW []
synonym: "interleukin-1, Type I receptor ligand" NARROW []
is_a: GO:0005149 ! interleukin-1 receptor binding

[Term]
id: GO:0005151
name: interleukin-1, Type II receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a Type II interleukin-1 receptor." [GOC:ai]
synonym: "IL-1 type II" NARROW []
synonym: "interleukin-1, Type II receptor ligand" NARROW []
is_a: GO:0005149 ! interleukin-1 receptor binding

[Term]
id: GO:0005152
name: interleukin-1 receptor antagonist activity
namespace: molecular_function
def: "Blocks the binding of interleukin-1 to the interleukin-1 receptor complex." [GOC:ebc]
synonym: "IL-1ra" EXACT []
is_a: GO:0005126 ! cytokine receptor binding
is_a: GO:0019966 ! interleukin-1 binding
is_a: GO:0048019 ! receptor antagonist activity
relationship: part_of GO:0001960 ! negative regulation of cytokine-mediated signaling pathway

[Term]
id: GO:0005153
name: interleukin-8 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-8 receptor." [GOC:go_curators]
subset: goslim_chembl
synonym: "IL-8" NARROW []
synonym: "interleukin-8 receptor ligand" NARROW []
is_a: GO:0045236 ! CXCR chemokine receptor binding

[Term]
id: GO:0005154
name: epidermal growth factor receptor binding
namespace: molecular_function
alt_id: GO:0008185
def: "Interacting selectively and non-covalently with the epidermal growth factor receptor." [GOC:ai]
subset: goslim_chembl
synonym: "EGF" NARROW []
synonym: "EGF receptor binding" EXACT []
synonym: "EGF receptor ligand" NARROW []
synonym: "EGFR binding" EXACT []
synonym: "epidermal growth factor" NARROW []
synonym: "epidermal growth factor receptor ligand" NARROW []
synonym: "TGF-alpha receptor binding" EXACT []
synonym: "TGFalpha receptor binding" EXACT []
synonym: "transforming growth factor alpha" NARROW []
synonym: "transforming growth factor alpha receptor binding" EXACT []
synonym: "transforming growth factor alpha receptor ligand" NARROW []
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0005155
name: obsolete epidermal growth factor receptor activating ligand activity
namespace: molecular_function
def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:dph, GOC:mah, GOC:tb]
comment: This term was made obsolete because it represents both a biological process and a molecular function.
synonym: "EGF receptor activating ligand activity" EXACT []
synonym: "EGFR activating ligand activity" EXACT []
synonym: "epidermal growth factor receptor activating ligand activity" EXACT []
is_obsolete: true
replaced_by: GO:0005154
consider: GO:0030297
consider: GO:0045741

[Term]
id: GO:0005156
name: obsolete epidermal growth factor receptor inhibiting ligand activity
namespace: molecular_function
def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:dph, GOC:mah, GOC:tb]
comment: This term was made obsolete because it represents both a biological process and a molecular function.
synonym: "EGF receptor inhibiting ligand activity" EXACT []
synonym: "EGFR inhibiting ligand activity" EXACT []
synonym: "epidermal growth factor receptor inhibiting ligand activity" EXACT []
is_obsolete: true
replaced_by: GO:0005154
consider: GO:0007175
consider: GO:0030293

[Term]
id: GO:0005157
name: macrophage colony-stimulating factor receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the macrophage colony-stimulating factor receptor." [GOC:ai]
synonym: "M-CSF receptor binding" EXACT [GOC:vk]
synonym: "macrophage colony stimulating factor receptor binding" EXACT []
synonym: "macrophage colony-stimulating factor receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0005158
name: insulin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the insulin receptor." [GOC:ai]
synonym: "insulin receptor ligand" NARROW []
is_a: GO:0005102 ! receptor binding
is_a: GO:0032403 ! protein complex binding

[Term]
id: GO:0005159
name: insulin-like growth factor receptor binding
namespace: molecular_function
alt_id: GO:0005067
def: "Interacting selectively and non-covalently with the insulin-like growth factor receptor." [GOC:jl]
synonym: "IGF receptor binding" EXACT []
synonym: "insulin-like growth factor" NARROW []
synonym: "insulin-like growth factor receptor ligand" NARROW []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0005160
name: transforming growth factor beta receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the transforming growth factor beta receptor." [GOC:ai]
synonym: "activin" RELATED []
synonym: "inhibin" RELATED []
synonym: "TGF-beta receptor binding" EXACT []
synonym: "TGFbeta receptor binding" EXACT []
synonym: "transforming growth factor beta" NARROW []
synonym: "transforming growth factor beta ligand binding to type I receptor" RELATED []
synonym: "transforming growth factor beta ligand binding to type II receptor" RELATED []
synonym: "transforming growth factor beta receptor anchoring activity" RELATED []
synonym: "transforming growth factor beta receptor ligand" NARROW []
xref: Reactome:REACT_100659 "BMP2 binds to the receptor complex, Canis familiaris"
xref: Reactome:REACT_105409 "BMP2 binds to the receptor complex, Sus scrofa"
xref: Reactome:REACT_108688 "Dimeric TGF-beta1 binds to the receptor, Mus musculus"
xref: Reactome:REACT_12011 "BMP2 binds to the receptor complex, Homo sapiens"
xref: Reactome:REACT_30063 "BMP2 binds to the receptor complex, Danio rerio"
xref: Reactome:REACT_31071 "Dimeric TGF-beta1 binds to the receptor, Canis familiaris"
xref: Reactome:REACT_32632 "BMP2 binds to the receptor complex, Bos taurus"
xref: Reactome:REACT_32807 "BMP2 binds to the receptor complex, Xenopus tropicalis"
xref: Reactome:REACT_33156 "Dimeric TGF-beta1 binds to the receptor, Sus scrofa"
xref: Reactome:REACT_6872 "Dimeric TGF-beta1 binds to the receptor, Homo sapiens"
xref: Reactome:REACT_77960 "BMP2 binds to the receptor complex, Drosophila melanogaster"
xref: Reactome:REACT_79989 "Dimeric TGF-beta1 binds to the receptor, Bos taurus"
xref: Reactome:REACT_81507 "Dimeric TGF-beta1 binds to the receptor, Danio rerio"
xref: Reactome:REACT_83062 "Dimeric TGF-beta1 binds to the receptor, Xenopus tropicalis"
xref: Reactome:REACT_83649 "Dimeric TGF-beta1 binds to the receptor, Rattus norvegicus"
xref: Reactome:REACT_90687 "BMP2 binds to the receptor complex, Taeniopygia guttata"
xref: Reactome:REACT_91350 "BMP2 binds to the receptor complex, Mus musculus"
xref: Reactome:REACT_96112 "BMP2 binds to the receptor complex, Gallus gallus"
xref: Reactome:REACT_99246 "BMP2 binds to the receptor complex, Rattus norvegicus"
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0005161
name: platelet-derived growth factor receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the platelet-derived growth factor receptor." [GOC:ai]
synonym: "PDGF" NARROW []
synonym: "PDGF receptor binding" EXACT []
synonym: "PDGFR binding" EXACT []
synonym: "platelet-derived growth factor" NARROW []
synonym: "platelet-derived growth factor receptor ligand" NARROW []
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0005163
name: nerve growth factor receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the nerve growth factor receptor." [GOC:ai, PMID:15654015]
synonym: "nerve growth factor receptor ligand" NARROW []
synonym: "neurotrophin" NARROW []
synonym: "NGF receptor binding" EXACT []
is_a: GO:0005123 ! death receptor binding
is_a: GO:0005165 ! neurotrophin receptor binding

[Term]
id: GO:0005164
name: tumor necrosis factor receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the tumor necrosis factor receptor." [GOC:ai]
subset: goslim_chembl
synonym: "TNF receptor binding" EXACT []
synonym: "tumor necrosis factor" NARROW []
synonym: "tumor necrosis factor receptor ligand" NARROW []
is_a: GO:0032813 ! tumor necrosis factor receptor superfamily binding

[Term]
id: GO:0005165
name: neurotrophin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a neurotrophin receptor." [GOC:ai]
synonym: "neurotrophin" NARROW []
synonym: "neurotrophin receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0005166
name: neurotrophin p75 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the neurotrophin p75 receptor." [GOC:ai]
synonym: "neurotrophin p75 receptor ligand" NARROW []
is_a: GO:0005165 ! neurotrophin receptor binding

[Term]
id: GO:0005167
name: neurotrophin TRK receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a neurotrophin TRK receptor." [GOC:ai]
synonym: "neurotrophin TRK receptor ligand" NARROW []
is_a: GO:0005165 ! neurotrophin receptor binding

[Term]
id: GO:0005168
name: neurotrophin TRKA receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the neurotrophin TRKA receptor." [GOC:ai]
synonym: "neurotrophin TRKA receptor ligand" NARROW []
is_a: GO:0005167 ! neurotrophin TRK receptor binding

[Term]
id: GO:0005169
name: neurotrophin TRKB receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the neurotrophin TRKB receptor." [GOC:ai]
synonym: "neurotrophin TRKB receptor ligand" NARROW []
is_a: GO:0005167 ! neurotrophin TRK receptor binding

[Term]
id: GO:0005170
name: neurotrophin TRKC receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the neurotrophin TRKC receptor." [GOC:ai]
synonym: "neurotrophin TRKC receptor ligand" NARROW []
is_a: GO:0005167 ! neurotrophin TRK receptor binding

[Term]
id: GO:0005171
name: hepatocyte growth factor receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the hepatocyte growth factor receptor." [GOC:ai]
synonym: "hepatocyte growth factor" NARROW []
synonym: "hepatocyte growth factor receptor ligand" NARROW []
synonym: "HGF receptor binding" EXACT []
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0005172
name: vascular endothelial growth factor receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any vascular endothelial growth factor receptor." [GOC:ai]
synonym: "vascular endothelial growth factor" NARROW []
synonym: "vascular endothelial growth factor receptor ligand" NARROW []
synonym: "VEGF receptor binding" EXACT []
synonym: "VEGFR binding" EXACT []
is_a: GO:0005126 ! cytokine receptor binding
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0005173
name: stem cell factor receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the stem cell factor receptor (SCFR), a type III transmembrane kinase receptor." [GOC:jl, PMID:10698217]
synonym: "KIT binding" NARROW []
synonym: "SCF" NARROW []
synonym: "SCFR binding" EXACT []
synonym: "stem cell factor" NARROW []
synonym: "stem cell factor receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0005174
name: CD40 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with CD40, a receptor found on the surface of all B-lymphocytes." [GOC:jl, ISBN:0120781859]
is_a: GO:0032813 ! tumor necrosis factor receptor superfamily binding

[Term]
id: GO:0005175
name: CD27 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a CD27, a receptor found on the surface of T cells and some B cells and NK cells." [GOC:jl, ISBN:0120781859]
is_a: GO:0032813 ! tumor necrosis factor receptor superfamily binding

[Term]
id: GO:0005176
name: ErbB-2 class receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the protein-tyrosine kinase receptor Neu/ErbB-2/HER2." [GOC:jl]
synonym: "ErbB-2 class receptor ligand" NARROW []
synonym: "HER2 receptor binding" EXACT []
synonym: "HER2 receptor ligand" NARROW []
synonym: "Neu receptor binding" EXACT []
synonym: "Neu receptor ligand" NARROW []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0005177
name: obsolete neuroligin
namespace: molecular_function
def: "OBSOLETE. A class of ligands for neurexins." [GOC:ai]
synonym: "neuroligin" EXACT []
is_obsolete: true
consider: GO:0042043

[Term]
id: GO:0005178
name: integrin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an integrin." [GOC:ceb]
subset: goslim_chembl
synonym: "integrin ligand" NARROW []
is_a: GO:0005102 ! receptor binding
is_a: GO:0032403 ! protein complex binding
is_a: GO:0050839 ! cell adhesion molecule binding

[Term]
id: GO:0005179
name: hormone activity
namespace: molecular_function
def: "The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process." [GOC:dph, GOC:mah, ISBN:0198506732]
subset: goslim_chembl
synonym: "cAMP generating peptide activity" NARROW []
synonym: "glycopeptide hormone" NARROW []
synonym: "lipopeptide hormone" NARROW []
synonym: "peptide hormone" NARROW []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0005180
name: obsolete peptide hormone
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it describes a type of hormone rather than a molecular function.
synonym: "peptide hormone" EXACT []
is_obsolete: true
consider: GO:0005179

[Term]
id: GO:0005181
name: obsolete glycopeptide hormone
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it describes a type of hormone rather than a molecular function.
synonym: "glycopeptide hormone" EXACT []
is_obsolete: true
consider: GO:0005179

[Term]
id: GO:0005182
name: obsolete lipopeptide hormone
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it describes a type of hormone rather than a molecular function.
synonym: "lipopeptide hormone" EXACT []
is_obsolete: true
consider: GO:0005179

[Term]
id: GO:0005183
name: gonadotropin hormone-releasing hormone activity
namespace: molecular_function
def: "The action characteristic of gonadotropin hormone-releasing hormone (GnRH), any of a family of decapeptide amide hormones that are released by the hypothalamus in response to neural and/or chemical stimuli. In at least mammals, upon receptor binding, GnRH causes the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by the anterior pituitary." [ISBN:0198506732, PMID:11026571, Wikipedia:Gonadotropin-releasing_hormone]
synonym: "GnRH activity" EXACT [ISBN:0198506732]
synonym: "gonadotrophin hormone-releasing hormone activity" EXACT [GOC:dph]
synonym: "LH/FSH-RF" EXACT [ISBN:0198506732]
synonym: "LHRH activity" EXACT [ISBN:0198506732]
synonym: "luteinizing hormone-releasing factor activity" EXACT [ISBN:0198506732]
synonym: "luteinizing hormone-releasing hormone activity" EXACT [ISBN:0198506732]
synonym: "luteinizing hormone/follicle-stimulating hormone releasing factor activity" EXACT [ISBN:0198506732]
is_a: GO:0005179 ! hormone activity

[Term]
id: GO:0005184
name: neuropeptide hormone activity
namespace: molecular_function
def: "The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones." [GOC:mah]
subset: goslim_chembl
synonym: "neurohormone" EXACT []
xref: Wikipedia:Neurohormone
is_a: GO:0005179 ! hormone activity

[Term]
id: GO:0005185
name: neurohypophyseal hormone activity
namespace: molecular_function
def: "The action characteristic of a neurohypophyseal hormone, any of a family of structurally and functionally related nonapeptides that are synthesized as part of a larger precursor molecule comprising a signal peptide, the nonapeptide hormone, and a neurophysin." [GOC:mah, PMID:19243634]
synonym: "neurohypophysial hormone activity" EXACT [GOC:mah]
is_a: GO:0005184 ! neuropeptide hormone activity

[Term]
id: GO:0005186
name: pheromone activity
namespace: molecular_function
def: "The activity of binding to and activating specific cell surface receptors, thereby inducing behavioral, developmental, or physiological response(s) from a responding organism or cell. The substance may be released or retained on the cell surface. Pheromones may serve as a specific attractant, social communicator, or sexual stimulant." [GOC:sgd_curators, ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0005187
name: obsolete storage protein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it describes a cellular location rather than a function.
synonym: "storage protein" EXACT []
is_obsolete: true
replaced_by: GO:0045735

[Term]
id: GO:0005188
name: obsolete larval serum protein (sensu Insecta)
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it describes presence in body fluids rather than an activity.
synonym: "arylphorin" NARROW []
synonym: "larval serum protein (sensu Insecta)" EXACT []
is_obsolete: true

[Term]
id: GO:0005189
name: obsolete milk protein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it describes presence in body fluids rather than an activity.
synonym: "milk protein" EXACT []
is_obsolete: true

[Term]
id: GO:0005190
name: obsolete seminal fluid protein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it describes presence in body fluids rather than an activity.
synonym: "seminal fluid protein" EXACT []
is_obsolete: true

[Term]
id: GO:0005191
name: obsolete acidic epididymal glycoprotein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it describes modification and presence in body fluids rather than an activity.
synonym: "acidic epididymal glycoprotein" EXACT []
is_obsolete: true

[Term]
id: GO:0005192
name: obsolete urinary protein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it describes presence in body fluids rather than an activity.
synonym: "urinary protein" EXACT []
is_obsolete: true

[Term]
id: GO:0005193
name: obsolete major urinary protein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it describes presence in body fluids rather than an activity.
synonym: "major urinary protein" EXACT []
is_obsolete: true

[Term]
id: GO:0005194
name: obsolete cell adhesion molecule activity
namespace: molecular_function
def: "OBSOLETE. Mediates the adhesion of the cell to other cells or to the extracellular matrix." [ISBN:0198506732]
comment: This term was made obsolete because it represents gene products involved in the biological process of cell adhesion.
synonym: "cell adhesion molecule activity" EXACT []
is_obsolete: true
consider: GO:0005102
consider: GO:0005515
consider: GO:0007155
consider: GO:0016021
consider: GO:0030246
consider: GO:0050839

[Term]
id: GO:0005198
name: structural molecule activity
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0005199
name: structural constituent of cell wall
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of a cell wall." [GOC:mah]
subset: gosubset_prok
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0005200
name: structural constituent of cytoskeleton
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]
subset: gosubset_prok
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0005201
name: extracellular matrix structural constituent
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]
subset: gosubset_prok
synonym: "extracellular matrix glycoprotein" NARROW []
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0005202
name: obsolete collagen
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it does not represent a molecular function.
synonym: "collagen" EXACT []
is_obsolete: true
consider: GO:0005581

[Term]
id: GO:0005203
name: obsolete proteoglycan
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it describes the composition (i.e. proteoglycan) of a gene product, not a molecular function.
synonym: "proteoglycan" EXACT []
is_obsolete: true

[Term]
id: GO:0005204
name: obsolete chondroitin sulfate proteoglycan
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it describes the composition (i.e. proteoglycan) of a gene product, not a molecular function.
synonym: "chondroitin sulfate proteoglycan" EXACT []
synonym: "chondroitin sulphate proteoglycan" EXACT []
is_obsolete: true

[Term]
id: GO:0005205
name: obsolete chondroitin sulfate/dermatan sulfate proteoglycan
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it describes the composition (i.e. proteoglycan) of a gene product, not a molecular function.
synonym: "chondroitin sulfate/dermatan sulfate proteoglycan" EXACT []
synonym: "chondroitin sulphate/dermatan sulphate proteoglycan" EXACT []
is_obsolete: true

[Term]
id: GO:0005206
name: obsolete heparin sulfate proteoglycan
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "heparin sulfate proteoglycan" EXACT []
synonym: "heparin sulphate proteoglycan" EXACT []
is_obsolete: true

[Term]
id: GO:0005207
name: obsolete extracellular matrix glycoprotein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it describes localization and modification rather than activity.
synonym: "extracellular matrix glycoprotein" EXACT []
is_obsolete: true
consider: GO:0005201

[Term]
id: GO:0005208
name: obsolete amyloid protein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "amyloid protein" EXACT []
is_obsolete: true

[Term]
id: GO:0005209
name: obsolete plasma protein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it describes presence in body fluids rather than an activity.
synonym: "plasma protein" EXACT []
is_obsolete: true

[Term]
id: GO:0005211
name: obsolete plasma glycoprotein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it describes modification and presence in body fluids rather than an activity.
synonym: "plasma glycoprotein" EXACT []
is_obsolete: true

[Term]
id: GO:0005212
name: structural constituent of eye lens
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of the lens of an eye." [GOC:mah]
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0005213
name: structural constituent of chorion
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of a chorion. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:sensu]
synonym: "structural protein of chorion" NARROW []
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0005214
name: structural constituent of chitin-based cuticle
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of a chitin-based cuticle. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
is_a: GO:0042302 ! structural constituent of cuticle

[Term]
id: GO:0005215
name: transporter activity
namespace: molecular_function
alt_id: GO:0005478
def: "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "small-molecule carrier or transporter" RELATED []
xref: Reactome:REACT_6315 "Virion-associated M2 protein mediated ion infusion, Homo sapiens"
is_a: GO:0003674 ! molecular_function
relationship: part_of GO:0006810 ! transport

[Term]
id: GO:0005216
name: ion channel activity
namespace: molecular_function
def: "Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0015075 ! ion transmembrane transporter activity
is_a: GO:0022838 ! substrate-specific channel activity

[Term]
id: GO:0005217
name: intracellular ligand-gated ion channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of an ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015276 ! ligand-gated ion channel activity

[Term]
id: GO:0005219
name: ryanodine-sensitive calcium-release channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts." [GOC:dph, GOC:tb]
synonym: "caffeine-sensitive calcium-release channel" RELATED []
synonym: "ryanodine receptor" NARROW []
is_a: GO:0015278 ! calcium-release channel activity

[Term]
id: GO:0005220
name: inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
namespace: molecular_function
alt_id: GO:0008095
def: "Enables the transmembrane transfer of a calcium ion by a channel that opens when inositol 1,4,5-trisphosphate (IP3) has been bound by the channel complex or one of its constituent parts." [GOC:mah, GOC:signaling, PMID:8660280, Wikipedia:Inositol_trisphosphate_receptor]
synonym: "inositol-1,4,5-trisphosphate receptor activity" EXACT []
synonym: "InsP3 receptor" EXACT [GOC:bf]
synonym: "IP3 receptor activity" EXACT []
is_a: GO:0015278 ! calcium-release channel activity
relationship: has_part GO:0070679 ! inositol 1,4,5 trisphosphate binding
relationship: part_of GO:0048016 ! inositol phosphate-mediated signaling

[Term]
id: GO:0005221
name: intracellular cyclic nucleotide activated cation channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a cation by a channel that opens when intracellular cyclic nucleotide has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport]
is_a: GO:0005217 ! intracellular ligand-gated ion channel activity
is_a: GO:0005261 ! cation channel activity
is_a: GO:0043855 ! cyclic nucleotide-gated ion channel activity

[Term]
id: GO:0005222
name: intracellular cAMP activated cation channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport]
synonym: "HCN channel activity" BROAD [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "hyperpolarization-activated cyclic nucleotide-gated channel activity" BROAD [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "intracellular 3',5' cAMP activated cation channel activity" EXACT []
synonym: "intracellular 3',5'-cAMP activated cation channel activity" EXACT []
synonym: "intracellular adenosine 3',5'-cyclophosphate activated cation channel activity" EXACT []
synonym: "intracellular cyclic AMP activated cation channel activity" EXACT []
is_a: GO:0005221 ! intracellular cyclic nucleotide activated cation channel activity

[Term]
id: GO:0005223
name: intracellular cGMP activated cation channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a cation by a channel that opens when intracellular cGMP has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport]
is_a: GO:0005221 ! intracellular cyclic nucleotide activated cation channel activity

[Term]
id: GO:0005224
name: ATP-binding and phosphorylation-dependent chloride channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a chloride ion by a channel that opens when ATP has been bound by the channel complex or one of its constituent parts." [GOC:mah]
is_a: GO:0005217 ! intracellular ligand-gated ion channel activity
is_a: GO:0005254 ! chloride channel activity

[Term]
id: GO:0005225
name: volume-sensitive anion channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of an anion by a volume-sensitive channel. An anion is a negatively charged ion. A volume-sensitive channel is a channel that responds to changes in the volume of a cell." [GOC:dph, GOC:tb]
synonym: "volume-regulated channel" BROAD []
is_a: GO:0005253 ! anion channel activity
relationship: part_of GO:0044070 ! regulation of anion transport

[Term]
id: GO:0005227
name: calcium activated cation channel activity
namespace: molecular_function
def: "Enables the calcium concentration-regulatable energy-independent passage of cations across a lipid bilayer down a concentration gradient." [GOC:dph, GOC:mtg_transport]
synonym: "intracellular calcium-activated potassium channel" NARROW []
synonym: "polycystin" NARROW []
is_a: GO:0005261 ! cation channel activity
is_a: GO:0022839 ! ion gated channel activity

[Term]
id: GO:0005228
name: intracellular sodium activated potassium channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of potassium by a channel that opens in response to stimulus by a sodium ion or ions. Transport by a channel involves facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. Sodium activated potassium channels have distinctive properties, including a large single channel conductance, subconductance states, and a block of single channel currents at positive potentials, similar to inward rectification." [GOC:mtg_transport, PMID:12628167]
is_a: GO:0005267 ! potassium channel activity
is_a: GO:0022839 ! ion gated channel activity

[Term]
id: GO:0005229
name: intracellular calcium activated chloride channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of chloride by a channel that opens in response to stimulus by a calcium ion or ions. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism." [GOC:mtg_transport]
is_a: GO:0005254 ! chloride channel activity
is_a: GO:0022839 ! ion gated channel activity

[Term]
id: GO:0005230
name: extracellular ligand-gated ion channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0015276 ! ligand-gated ion channel activity

[Term]
id: GO:0005231
name: excitatory extracellular ligand-gated ion channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular excitatory ligand has been bound by the channel complex or one of its constituent parts. Excitatory ligands, such as acetylcholine or glutamate, open cation-selective channels." [GOC:mah, ISBN:0323037070]
subset: gosubset_prok
xref: Reactome:REACT_100575 "Activation of Ca permeable AMPA receptors, Drosophila melanogaster"
xref: Reactome:REACT_100719 "Activation of NMDA Receptor, Xenopus tropicalis"
xref: Reactome:REACT_100732 "Activation of Ca permeable AMPA receptors, Xenopus tropicalis"
xref: Reactome:REACT_101885 "Activation of Ca permeable AMPA receptors, Drosophila melanogaster"
xref: Reactome:REACT_102403 "Activation of Ca impermeable AMPA receptors, Drosophila melanogaster"
xref: Reactome:REACT_102868 "Unblocking of NMDA receptor, Rattus norvegicus"
xref: Reactome:REACT_103824 "Activation of Ca permeable AMPA receptors, Gallus gallus"
xref: Reactome:REACT_104230 "Activation of NMDA Receptor, Canis familiaris"
xref: Reactome:REACT_106345 "Activation of NMDA Receptor, Mus musculus"
xref: Reactome:REACT_106759 "Activation of Ca impermeable AMPA receptors, Bos taurus"
xref: Reactome:REACT_107388 "Activation of Ca permeable AMPA receptors, Taeniopygia guttata"
xref: Reactome:REACT_107468 "Unblocking of NMDA receptor, Danio rerio"
xref: Reactome:REACT_107584 "Membrane depolarization upon activation of Ca impermeable AMPA receptors, Danio rerio"
xref: Reactome:REACT_108021 "Activation of Ca permeable AMPA receptors, Mus musculus"
xref: Reactome:REACT_108304 "Membrane depolarization upon activation of Ca impermeable AMPA receptors, Rattus norvegicus"
xref: Reactome:REACT_112215 "Activation of Ca permeable AMPA receptors, Caenorhabditis elegans"
xref: Reactome:REACT_112384 "Membrane depolarization upon activation of Ca impermeable AMPA receptors, Caenorhabditis elegans"
xref: Reactome:REACT_112847 "Unblocking of NMDA receptor, Caenorhabditis elegans"
xref: Reactome:REACT_112878 "Membrane depolarization upon activation of Ca impermeable AMPA receptors, Xenopus tropicalis"
xref: Reactome:REACT_113112 "Unblocking of NMDA receptor, Xenopus tropicalis"
xref: Reactome:REACT_113296 "Activation of Ca impermeable AMPA receptors, Xenopus tropicalis"
xref: Reactome:REACT_115321 "Activation of Ca permeable AMPA receptors, Caenorhabditis elegans"
xref: Reactome:REACT_115442 "Activation of Ca impermeable AMPA receptors, Caenorhabditis elegans"
xref: Reactome:REACT_18258 "Activation of Ca permeable AMPA receptors, Homo sapiens"
xref: Reactome:REACT_18378 "Activation of Ca permeable AMPA receptors, Homo sapiens"
xref: Reactome:REACT_18434 "Activation of Ca impermeable AMPA receptors, Homo sapiens"
xref: Reactome:REACT_20499 "Activation of NMDA Receptor, Homo sapiens"
xref: Reactome:REACT_20500 "Unblocking of NMDA receptor, Homo sapiens"
xref: Reactome:REACT_20566 "CaMKII enters cytoplasm, Homo sapiens"
xref: Reactome:REACT_20569 "Membrane depolarization upon activation of Ca impermeable AMPA receptors, Homo sapiens"
xref: Reactome:REACT_20670 "Activation of RasGRF, Homo sapiens"
xref: Reactome:REACT_29161 "Activation of Ca permeable AMPA receptors, Canis familiaris"
xref: Reactome:REACT_29951 "Activation of NMDA Receptor, Drosophila melanogaster"
xref: Reactome:REACT_30649 "Activation of Ca impermeable AMPA receptors, Taeniopygia guttata"
xref: Reactome:REACT_31264 "Activation of Ca impermeable AMPA receptors, Mus musculus"
xref: Reactome:REACT_32098 "Unblocking of NMDA receptor, Mus musculus"
xref: Reactome:REACT_34112 "Activation of Ca permeable AMPA receptors, Gallus gallus"
xref: Reactome:REACT_76952 "Activation of Ca permeable AMPA receptors, Mus musculus"
xref: Reactome:REACT_77270 "Activation of Ca impermeable AMPA receptors, Rattus norvegicus"
xref: Reactome:REACT_78690 "Activation of NMDA Receptor, Caenorhabditis elegans"
xref: Reactome:REACT_81538 "Activation of Ca permeable AMPA receptors, Taeniopygia guttata"
xref: Reactome:REACT_81709 "Activation of NMDA Receptor, Danio rerio"
xref: Reactome:REACT_83254 "Activation of Ca impermeable AMPA receptors, Canis familiaris"
xref: Reactome:REACT_86617 "Activation of Ca permeable AMPA receptors, Danio rerio"
xref: Reactome:REACT_87375 "Activation of Ca permeable AMPA receptors, Canis familiaris"
xref: Reactome:REACT_87873 "Activation of Ca impermeable AMPA receptors, Danio rerio"
xref: Reactome:REACT_88526 "Activation of Ca permeable AMPA receptors, Danio rerio"
xref: Reactome:REACT_88930 "Unblocking of NMDA receptor, Drosophila melanogaster"
xref: Reactome:REACT_90406 "Activation of Ca permeable AMPA receptors, Xenopus tropicalis"
xref: Reactome:REACT_91469 "Activation of Ca permeable AMPA receptors, Bos taurus"
xref: Reactome:REACT_91763 "Membrane depolarization upon activation of Ca impermeable AMPA receptors, Canis familiaris"
xref: Reactome:REACT_91977 "Membrane depolarization upon activation of Ca impermeable AMPA receptors, Mus musculus"
xref: Reactome:REACT_95119 "Membrane depolarization upon activation of Ca impermeable AMPA receptors, Drosophila melanogaster"
xref: Reactome:REACT_95430 "Unblocking of NMDA receptor, Canis familiaris"
xref: Reactome:REACT_95572 "Activation of Ca permeable AMPA receptors, Bos taurus"
xref: Reactome:REACT_96574 "Activation of Ca impermeable AMPA receptors, Gallus gallus"
xref: Reactome:REACT_99356 "Activation of NMDA Receptor, Rattus norvegicus"
is_a: GO:0005230 ! extracellular ligand-gated ion channel activity

[Term]
id: GO:0005232
name: serotonin-activated cation-selective channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a cation by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, and that is activated by serotonin." [GOC:mah]
comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'serotonin receptor activity ; GO:0004993'.
synonym: "5-hydroxytryptamine-gated receptor-channel" EXACT []
xref: Reactome:REACT_25246 "The 5-HT3 receptor complex is permeable to Na+,K+, and Ca2+ when it binds serotonin (5-HT), Homo sapiens"
is_a: GO:0005231 ! excitatory extracellular ligand-gated ion channel activity
is_a: GO:0005261 ! cation channel activity

[Term]
id: GO:0005234
name: extracellular-glutamate-gated ion channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'glutamate receptor activity ; GO:0008066'.
subset: gosubset_prok
is_a: GO:0005231 ! excitatory extracellular ligand-gated ion channel activity

[Term]
id: GO:0005237
name: inhibitory extracellular ligand-gated ion channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular inhibitory ligand has been bound by the channel complex or one of its constituent parts. Inhibitory ligands, such as GABA or glycine, open chloride-selective channels." [GOC:mah, ISBN:0323037070]
is_a: GO:0005230 ! extracellular ligand-gated ion channel activity

[Term]
id: GO:0005240
name: obsolete glycine receptor-associated protein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it does not describe a molecular function.
synonym: "glycine receptor-associated protein" EXACT []
is_obsolete: true
consider: GO:0005515

[Term]
id: GO:0005241
name: obsolete inward rectifier channel
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because more specific terms were created.
synonym: "inward rectifier channel" EXACT []
is_obsolete: true
consider: GO:0005242

[Term]
id: GO:0005242
name: inward rectifier potassium channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself." [GOC:cb, GOC:mah, PMID:14977398]
subset: gosubset_prok
synonym: "Kir channel activity" EXACT [GOC:cb]
xref: Reactome:REACT_111144 "Activation of ATP sensitive Potassium channels in muscle cells, Homo sapiens"
xref: Reactome:REACT_75758 "Activation of classical Kir channels, Homo sapiens"
xref: Reactome:REACT_75810 "Activation of Potassium transport channels, Homo sapiens"
xref: Reactome:REACT_75911 "Activation of ATP sensitive Potassium channels in neuroendocrine cells, Homo sapiens"
is_a: GO:0005249 ! voltage-gated potassium channel activity
is_a: GO:0015276 ! ligand-gated ion channel activity

[Term]
id: GO:0005243
name: gap junction channel activity
namespace: molecular_function
alt_id: GO:0015285
alt_id: GO:0015286
def: "A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes." [GOC:dgh, GOC:mtg_transport, ISBN:0815340729]
synonym: "connexin" RELATED []
synonym: "innexin" NARROW []
synonym: "innexin channel activity" EXACT []
synonym: "intercellular channel" BROAD []
xref: Reactome:REACT_101905 "Pannexin 1/Pannexin2 mediated neuronal gap junction communication, Taeniopygia guttata"
xref: Reactome:REACT_102059 "Connexin 36 mediated neuronal gap junction communication, Xenopus tropicalis"
xref: Reactome:REACT_103167 "Pannexin 1/Pannexin2 mediated neuronal gap junction communication, Bos taurus"
xref: Reactome:REACT_103805 "Connexin 45/Connexin 36 mediated neuronal gap junction communication, Canis familiaris"
xref: Reactome:REACT_104774 "Connexin 36 mediated neuronal gap junction communication, Sus scrofa"
xref: Reactome:REACT_105310 "Connexin 36 mediated neuronal gap junction communication, Mus musculus"
xref: Reactome:REACT_105458 "Connexin 62 mediated neuronal gap junction communication, Mus musculus"
xref: Reactome:REACT_105553 "Connexin 36 mediated neuronal gap junction communication, Danio rerio"
xref: Reactome:REACT_106238 "Connexin 36 mediated neuronal gap junction communication, Gallus gallus"
xref: Reactome:REACT_108777 "Pannexin 1/Pannexin2 mediated neuronal gap junction communication, Sus scrofa"
xref: Reactome:REACT_109272 "Pannexin 1/Pannexin2 mediated neuronal gap junction communication, Canis familiaris"
xref: Reactome:REACT_109519 "Connexin 62 mediated neuronal gap junction communication, Rattus norvegicus"
xref: Reactome:REACT_112884 "Connexin 62 mediated neuronal gap junction communication, Xenopus tropicalis"
xref: Reactome:REACT_115511 "Pannexin 1/Pannexin2 mediated neuronal gap junction communication, Xenopus tropicalis"
xref: Reactome:REACT_16954 "Pannexin 1/Pannexin2 mediated neuronal gap junction communication, Homo sapiens"
xref: Reactome:REACT_16981 "Connexin 36 mediated neuronal gap junction communication, Homo sapiens"
xref: Reactome:REACT_16989 "Connexin 45/Connexin 36 mediated neuronal gap junction communication, Homo sapiens"
xref: Reactome:REACT_17030 "Connexin 62 mediated neuronal gap junction communication, Homo sapiens"
xref: Reactome:REACT_28817 "Connexin 62 mediated neuronal gap junction communication, Gallus gallus"
xref: Reactome:REACT_29579 "Connexin 36 mediated neuronal gap junction communication, Rattus norvegicus"
xref: Reactome:REACT_31881 "Connexin 45/Connexin 36 mediated neuronal gap junction communication, Taeniopygia guttata"
xref: Reactome:REACT_32063 "Connexin 45/Connexin 36 mediated neuronal gap junction communication, Gallus gallus"
xref: Reactome:REACT_32264 "Connexin oligomerization in endoplasmic reticulum membrane, Rattus norvegicus"
xref: Reactome:REACT_32491 "Connexin 62 mediated neuronal gap junction communication, Sus scrofa"
xref: Reactome:REACT_48932 "Connexin 36 mediated neuronal gap junction communication, Bos taurus"
xref: Reactome:REACT_55534 "Connexin 45/Connexin 36 mediated neuronal gap junction communication, Mus musculus"
xref: Reactome:REACT_77021 "Connexin 45/Connexin 36 mediated neuronal gap junction communication, Danio rerio"
xref: Reactome:REACT_78873 "Connexin 36 mediated neuronal gap junction communication, Canis familiaris"
xref: Reactome:REACT_79029 "Connexin 62 mediated neuronal gap junction communication, Canis familiaris"
xref: Reactome:REACT_80444 "Pannexin 1/Pannexin2 mediated neuronal gap junction communication, Gallus gallus"
xref: Reactome:REACT_81724 "Connexin oligomerization in endoplasmic reticulum membrane, Canis familiaris"
xref: Reactome:REACT_82752 "Connexin oligomerization in endoplasmic reticulum membrane, Sus scrofa"
xref: Reactome:REACT_83077 "Connexin oligomerization in endoplasmic reticulum membrane, Taeniopygia guttata"
xref: Reactome:REACT_84620 "Pannexin 1/Pannexin2 mediated neuronal gap junction communication, Rattus norvegicus"
xref: Reactome:REACT_85116 "Connexin oligomerization in endoplasmic reticulum membrane, Bos taurus"
xref: Reactome:REACT_85222 "Connexin 45/Connexin 36 mediated neuronal gap junction communication, Sus scrofa"
xref: Reactome:REACT_85490 "Connexin oligomerization in endoplasmic reticulum membrane, Xenopus tropicalis"
xref: Reactome:REACT_91738 "Pannexin 1/Pannexin2 mediated neuronal gap junction communication, Danio rerio"
xref: Reactome:REACT_92145 "Connexin 36 mediated neuronal gap junction communication, Taeniopygia guttata"
xref: Reactome:REACT_92401 "Connexin 45/Connexin 36 mediated neuronal gap junction communication, Bos taurus"
xref: Reactome:REACT_93393 "Connexin oligomerization in endoplasmic reticulum membrane, Danio rerio"
xref: Reactome:REACT_93951 "Connexin 45/Connexin 36 mediated neuronal gap junction communication, Xenopus tropicalis"
xref: Reactome:REACT_9494 "Connexin oligomerization in endoplasmic reticulum membrane, Homo sapiens"
xref: Reactome:REACT_97128 "Connexin 62 mediated neuronal gap junction communication, Bos taurus"
xref: Reactome:REACT_97818 "Pannexin 1/Pannexin2 mediated neuronal gap junction communication, Mus musculus"
xref: Reactome:REACT_99359 "Connexin oligomerization in endoplasmic reticulum membrane, Gallus gallus"
xref: Reactome:REACT_99875 "Connexin oligomerization in endoplasmic reticulum membrane, Mus musculus"
is_a: GO:0022829 ! wide pore channel activity

[Term]
id: GO:0005244
name: voltage-gated ion channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
subset: gosubset_prok
synonym: "voltage gated ion channel activity" EXACT []
synonym: "voltage-dependent ion channel activity" EXACT []
is_a: GO:0005216 ! ion channel activity
is_a: GO:0022832 ! voltage-gated channel activity
relationship: part_of GO:0034765 ! regulation of ion transmembrane transport

[Term]
id: GO:0005245
name: voltage-gated calcium channel activity
namespace: molecular_function
alt_id: GO:0010173
alt_id: GO:0015270
def: "Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, GOC:tb, ISBN:0815340729]
synonym: "depolarization-activated calcium channel" BROAD []
synonym: "depolarization-activated voltage gated calcium channel activity" EXACT []
synonym: "depolarization-activated voltage-gated calcium channel" EXACT []
synonym: "depolarization-activated voltage-gated calcium channel activity" EXACT []
synonym: "dihydropyridine-sensitive calcium channel activity" NARROW []
synonym: "voltage gated calcium channel activity" EXACT []
synonym: "voltage-dependent calcium channel activity" EXACT []
synonym: "voltage-gated calcium ion channel activity" EXACT []
synonym: "voltage-sensitive calcium channel" EXACT []
xref: Reactome:REACT_16913 "Calcium Influx through Voltage-gated Calcium Channels, Homo sapiens"
xref: Reactome:REACT_31026 "Calcium Influx through Voltage-gated Calcium Channels, Bos taurus"
xref: Reactome:REACT_32868 "Calcium Influx through Voltage-gated Calcium Channels, Danio rerio"
xref: Reactome:REACT_75250 "Calcium Influx through Voltage-gated Calcium Channels, Canis familiaris"
xref: Reactome:REACT_77953 "Calcium Influx through Voltage-gated Calcium Channels, Gallus gallus"
xref: Reactome:REACT_78315 "Calcium Influx through Voltage-gated Calcium Channels, Xenopus tropicalis"
xref: Reactome:REACT_82064 "Calcium Influx through Voltage-gated Calcium Channels, Rattus norvegicus"
xref: Reactome:REACT_82772 "Calcium Influx through Voltage-gated Calcium Channels, Sus scrofa"
xref: Reactome:REACT_95203 "Calcium Influx through Voltage-gated Calcium Channels, Taeniopygia guttata"
xref: Reactome:REACT_95927 "Calcium Influx through Voltage-gated Calcium Channels, Mus musculus"
is_a: GO:0005262 ! calcium channel activity
is_a: GO:0022843 ! voltage-gated cation channel activity

[Term]
id: GO:0005246
name: calcium channel regulator activity
namespace: molecular_function
def: "Modulates the activity of a calcium channel." [GOC:mah]
is_a: GO:0016247 ! channel regulator activity
relationship: regulates GO:0005262 ! calcium channel activity

[Term]
id: GO:0005247
name: voltage-gated chloride channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "voltage gated chloride channel activity" EXACT []
synonym: "voltage-dependent chloride channel activity" EXACT []
is_a: GO:0005254 ! chloride channel activity
is_a: GO:0008308 ! voltage-gated anion channel activity

[Term]
id: GO:0005248
name: voltage-gated sodium channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]
synonym: "voltage gated sodium channel activity" EXACT []
synonym: "voltage-dependent sodium channel activity" EXACT []
synonym: "voltage-gated sodium ion channel activity" EXACT []
synonym: "voltage-sensitive sodium channel" EXACT []
is_a: GO:0005272 ! sodium channel activity
is_a: GO:1905030 ! voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential

[Term]
id: GO:0005249
name: voltage-gated potassium channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "voltage gated potassium channel activity" EXACT []
synonym: "voltage-dependent potassium channel activity" EXACT []
synonym: "voltage-gated potassium ion channel activity" EXACT []
synonym: "voltage-sensitive potassium channel" EXACT []
xref: Reactome:REACT_75857 "Activation of voltage gated Potassium channels, Homo sapiens"
is_a: GO:0005267 ! potassium channel activity
is_a: GO:0022843 ! voltage-gated cation channel activity

[Term]
id: GO:0005250
name: A-type (transient outward) potassium channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel that produces a transient outward current upon a step change in membrane potential." [GOC:mah, PMID:5575340]
is_a: GO:0015271 ! outward rectifier potassium channel activity

[Term]
id: GO:0005251
name: delayed rectifier potassium channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow." [GOC:mah, PMID:11343411, PMID:2462513]
is_a: GO:0005249 ! voltage-gated potassium channel activity

[Term]
id: GO:0005252
name: open rectifier potassium channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a potassium ion by an open rectifier voltage-gated channel. An open rectifier current-voltage relationship is one in which the direction of rectification depends on the external potassium ion concentration." [GOC:mah, PMID:8917578]
is_a: GO:0005249 ! voltage-gated potassium channel activity

[Term]
id: GO:0005253
name: anion channel activity
namespace: molecular_function
def: "Enables the energy-independent passage of anions across a lipid bilayer down a concentration gradient." [GOC:dph, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
subset: gosubset_prok
synonym: "non-selective anion channel activity" NARROW []
xref: Reactome:REACT_101693 "Passive Transport of Anions into Vesicles by Aquaporin-6, Mus musculus"
xref: Reactome:REACT_102137 "Passive Transport of Anions out of Vesicles by Aquaporin-6, Canis familiaris"
xref: Reactome:REACT_106855 "Passive Transport of Anions out of Vesicles by Aquaporin-6, Bos taurus"
xref: Reactome:REACT_109064 "Passive Transport of Anions into Vesicles by Aquaporin-6, Sus scrofa"
xref: Reactome:REACT_112326 "Passive Transport of Anions out of Vesicles by Aquaporin-6, Drosophila melanogaster"
xref: Reactome:REACT_115452 "Passive Transport of Anions into Vesicles by Aquaporin-6, Drosophila melanogaster"
xref: Reactome:REACT_115461 "Passive Transport of Anions into Vesicles by Aquaporin-6, Escherichia coli"
xref: Reactome:REACT_23819 "Passive Transport of Anions into Vesicles by Aquaporin-6, Homo sapiens"
xref: Reactome:REACT_23846 "Passive Transport of Anions into Vesicles by Aquaporin-6 (rat), Rattus norvegicus"
xref: Reactome:REACT_23871 "Passive Transport of Anions out of Vesicles by Aquaporin-6 (rat), Rattus norvegicus"
xref: Reactome:REACT_23883 "Passive Transport of Anions out of Vesicles by Aquaporin-6, Homo sapiens"
xref: Reactome:REACT_28951 "Passive Transport of Anions into Vesicles by Aquaporin-6, Xenopus tropicalis"
xref: Reactome:REACT_33937 "Passive Transport of Anions into Vesicles by Aquaporin-6, Canis familiaris"
xref: Reactome:REACT_34668 "Passive Transport of Anions out of Vesicles by Aquaporin-6, Xenopus tropicalis"
xref: Reactome:REACT_78821 "Passive Transport of Anions out of Vesicles by Aquaporin-6, Sus scrofa"
xref: Reactome:REACT_80814 "Passive Transport of Anions into Vesicles by Aquaporin-6, Saccharomyces cerevisiae"
xref: Reactome:REACT_85021 "Passive Transport of Anions into Vesicles by Aquaporin-6, Bos taurus"
xref: Reactome:REACT_85133 "Passive Transport of Anions out of Vesicles by Aquaporin-6, Saccharomyces cerevisiae"
xref: Reactome:REACT_89848 "Passive Transport of Anions out of Vesicles by Aquaporin-6, Mus musculus"
xref: Reactome:REACT_90444 "Passive Transport of Anions out of Vesicles by Aquaporin-6, Rattus norvegicus"
is_a: GO:0005216 ! ion channel activity
is_a: GO:0008509 ! anion transmembrane transporter activity
disjoint_from: GO:0005261 ! cation channel activity

[Term]
id: GO:0005254
name: chloride channel activity
namespace: molecular_function
def: "Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]
subset: gosubset_prok
xref: Reactome:REACT_110569 "Group 3 - Selective Cl- transport, Oryza sativa"
xref: Reactome:REACT_112123 "Group 3 - Selective Cl- transport, Plasmodium falciparum"
xref: Reactome:REACT_114749 "Group 3 - Selective Cl- transport, Dictyostelium discoideum"
xref: Reactome:REACT_19248 "Group 3 - Selective Cl- transport, Homo sapiens"
xref: Reactome:REACT_25130 "The GABA(A) receptor complex is permeable to Cl- when GABA binds to it, Homo sapiens"
xref: Reactome:REACT_25391 "The GABA(A)-rho receptor complex is permeable to Cl- when GABA binds to it, Homo sapiens"
xref: Reactome:REACT_30908 "Group 3 - Selective Cl- transport, Sus scrofa"
xref: Reactome:REACT_77358 "Group 3 - Selective Cl- transport, Gallus gallus"
xref: Reactome:REACT_79095 "Group 3 - Selective Cl- transport, Mycobacterium tuberculosis"
xref: Reactome:REACT_82572 "Group 3 - Selective Cl- transport, Arabidopsis thaliana"
xref: Reactome:REACT_84546 "Group 3 - Selective Cl- transport, Taeniopygia guttata"
xref: Reactome:REACT_86034 "Group 3 - Selective Cl- transport, Canis familiaris"
xref: Reactome:REACT_86525 "Group 3 - Selective Cl- transport, Mus musculus"
xref: Reactome:REACT_92217 "Group 3 - Selective Cl- transport, Bos taurus"
xref: Reactome:REACT_97596 "Group 3 - Selective Cl- transport, Xenopus tropicalis"
xref: Reactome:REACT_97793 "Group 3 - Selective Cl- transport, Rattus norvegicus"
is_a: GO:0005253 ! anion channel activity
is_a: GO:0015108 ! chloride transmembrane transporter activity

[Term]
id: GO:0005260
name: channel-conductance-controlling ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate. An animal enzyme that is active in forming a chloride channel, the absence of which brings about cystic fibrosis. It is also involved in the functioning of other transmembrane channels." [EC:3.6.3.49]
synonym: "ATP phosphohydrolase (channel-conductance-controlling)" EXACT [EC:3.6.3.49]
synonym: "cystic fibrosis transmembrane conductance regulator" NARROW []
synonym: "cystic-fibrosis membrane-conductance-regulating protein activity" NARROW [EC:3.6.3.49]
xref: EC:3.6.3.49
xref: MetaCyc:3.6.3.49-RXN
is_a: GO:0005254 ! chloride channel activity
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances

[Term]
id: GO:0005261
name: cation channel activity
namespace: molecular_function
alt_id: GO:0015281
alt_id: GO:0015338
def: "Enables the energy-independent passage of cations across a lipid bilayer down a concentration gradient." [GOC:def, GOC:dph, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
subset: gosubset_prok
synonym: "cation diffusion facilitator activity" EXACT []
synonym: "non-selective cation channel activity" NARROW []
xref: Reactome:REACT_101627 "Cation influx mediated by TRPC3/6/7, Canis familiaris"
xref: Reactome:REACT_102218 "Release of calcium from intracellular stores by IP3 receptor activation, Xenopus tropicalis"
xref: Reactome:REACT_104190 "Release of calcium from intracellular stores by IP3 receptor activation, Gallus gallus"
xref: Reactome:REACT_105802 "Cation influx mediated by TRPC3/6/7, Danio rerio"
xref: Reactome:REACT_110491 "Cation influx mediated by TRPC3/6/7, Rattus norvegicus"
xref: Reactome:REACT_112207 "Release of calcium from intracellular stores by IP3 receptor activation, Caenorhabditis elegans"
xref: Reactome:REACT_12074 "Release of calcium from intracellular stores by IP3 receptor activation, Homo sapiens"
xref: Reactome:REACT_18417 "Calcium release from intracellular stores by IP3 receptor activation, Rattus norvegicus"
xref: Reactome:REACT_23771 "Cation influx mediated by TRPC3/6/7, Homo sapiens"
xref: Reactome:REACT_28346 "Release of calcium from intracellular stores by IP3 receptor activation, Sus scrofa"
xref: Reactome:REACT_29129 "Cation influx mediated by TRPC3/6/7, Mus musculus"
xref: Reactome:REACT_30150 "Cation influx mediated by TRPC3/6/7, Sus scrofa"
xref: Reactome:REACT_30616 "Cation influx mediated by TRPC3/6/7, Xenopus tropicalis"
xref: Reactome:REACT_32084 "Cation influx mediated by TRPC3/6/7, Gallus gallus"
xref: Reactome:REACT_75788 "Activation of HCN channels, Homo sapiens"
xref: Reactome:REACT_79940 "Release of calcium from intracellular stores by IP3 receptor activation, Canis familiaris"
xref: Reactome:REACT_81162 "Release of calcium from intracellular stores by IP3 receptor activation, Bos taurus"
xref: Reactome:REACT_82565 "Release of calcium from intracellular stores by IP3 receptor activation, Drosophila melanogaster"
xref: Reactome:REACT_86105 "Cation influx mediated by TRPC3/6/7, Bos taurus"
xref: Reactome:REACT_92757 "Release of calcium from intracellular stores by IP3 receptor activation, Mus musculus"
xref: Reactome:REACT_92988 "Release of calcium from intracellular stores by IP3 receptor activation, Danio rerio"
xref: Reactome:REACT_96089 "Release of calcium from intracellular stores by IP3 receptor activation, Taeniopygia guttata"
xref: Reactome:REACT_98751 "Cation influx mediated by TRPC3/6/7, Taeniopygia guttata"
is_a: GO:0005216 ! ion channel activity
is_a: GO:0008324 ! cation transmembrane transporter activity

[Term]
id: GO:0005262
name: calcium channel activity
namespace: molecular_function
def: "Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]
xref: Reactome:REACT_102697 "P2X1-mediated entry of Ca++ from plasma, Gallus gallus"
xref: Reactome:REACT_103065 "P2X1-mediated entry of Ca++ from plasma, Rattus norvegicus"
xref: Reactome:REACT_105763 "Ca2+ influx through voltage gated Ca2+ channels, Sus scrofa"
xref: Reactome:REACT_106056 "Ca2+ influx through voltage gated Ca2+ channels, Canis familiaris"
xref: Reactome:REACT_109162 "Ca2+ influx through voltage gated Ca2+ channels, Danio rerio"
xref: Reactome:REACT_112515 "P2X1-mediated entry of Ca++ from plasma, Xenopus tropicalis"
xref: Reactome:REACT_114130 "Ca2+ influx through voltage gated Ca2+ channels, Xenopus tropicalis"
xref: Reactome:REACT_12594 "Ca2+ influx through voltage gated Ca2+ channels, Homo sapiens"
xref: Reactome:REACT_30251 "Ca2+ influx through voltage gated Ca2+ channels, Bos taurus"
xref: Reactome:REACT_32047 "P2X1-mediated entry of Ca++ from plasma, Sus scrofa"
xref: Reactome:REACT_33844 "P2X1-mediated entry of Ca++ from plasma, Danio rerio"
xref: Reactome:REACT_500 "P2X1-mediated entry of Ca++ from plasma, Homo sapiens"
xref: Reactome:REACT_77174 "Ca2+ influx through voltage gated Ca2+ channels, Rattus norvegicus"
xref: Reactome:REACT_80919 "P2X1-mediated entry of Ca++ from plasma, Bos taurus"
xref: Reactome:REACT_81993 "P2X1-mediated entry of Ca++ from plasma, Taeniopygia guttata"
xref: Reactome:REACT_83702 "P2X1-mediated entry of Ca++ from plasma, Canis familiaris"
xref: Reactome:REACT_89322 "Ca2+ influx through voltage gated Ca2+ channels, Taeniopygia guttata"
xref: Reactome:REACT_90881 "Ca2+ influx through voltage gated Ca2+ channels, Mus musculus"
xref: Reactome:REACT_93583 "P2X1-mediated entry of Ca++ from plasma, Mus musculus"
is_a: GO:0005261 ! cation channel activity
is_a: GO:0015085 ! calcium ion transmembrane transporter activity
relationship: part_of GO:0070588 ! calcium ion transmembrane transport

[Term]
id: GO:0005267
name: potassium channel activity
namespace: molecular_function
def: "Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
subset: gosubset_prok
xref: Reactome:REACT_75749 "Activation of TALK, Homo sapiens"
xref: Reactome:REACT_75757 "Activation of Ca2+ activated Potassium channels with large conductance, Homo sapiens"
xref: Reactome:REACT_75772 "Activation of THIK, Homo sapiens"
xref: Reactome:REACT_75793 "Activation of Ca2+ activated Potassium channels with Intermeidtance conductance, Homo sapiens"
xref: Reactome:REACT_75806 "Activation of tandem pore domain in a weak inwardly rectifying K+ channels, Homo sapiens"
xref: Reactome:REACT_75830 "Activation of Ca2+ activated Potassium channels with small conductance, Homo sapiens"
xref: Reactome:REACT_75846 "Activation of TWIK-related K+ channel (TREK), Homo sapiens"
xref: Reactome:REACT_75865 "Activation of TRESK, Homo sapiens"
xref: Reactome:REACT_75935 "Activation of TASK, Homo sapiens"
is_a: GO:0005261 ! cation channel activity
is_a: GO:0015079 ! potassium ion transmembrane transporter activity
relationship: part_of GO:0071805 ! potassium ion transmembrane transport

[Term]
id: GO:0005272
name: sodium channel activity
namespace: molecular_function
def: "Enables the facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
is_a: GO:0005261 ! cation channel activity
is_a: GO:0015081 ! sodium ion transmembrane transporter activity
relationship: part_of GO:0035725 ! sodium ion transmembrane transport

[Term]
id: GO:0005274
name: allantoin uptake transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015206
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: allantoin(out) + H+(out) = allantoin(in) + H+(in) by secondary active transport." [GOC:mtg_transport, ISBN:0815340729, TC:2.A.39.3.1]
synonym: "allantoin permease activity" RELATED []
synonym: "allantoin/allantoate transporter" BROAD []
is_a: GO:0015391 ! nucleobase:cation symporter activity
is_a: GO:0015563 ! uptake transmembrane transporter activity
is_a: GO:0042887 ! amide transmembrane transporter activity
relationship: part_of GO:0015720 ! allantoin transport

[Term]
id: GO:0005275
name: amine transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0005279
def: "Enables the transfer of amines, including polyamines, from one side of the membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
subset: gosubset_prok
synonym: "amine/amide/polyamine channel activity" BROAD []
synonym: "amine/polyamine transmembrane transporter activity" EXACT []
synonym: "amino acid-polyamine transmembrane transporter activity" EXACT []
is_a: GO:0022804 ! active transmembrane transporter activity
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity
relationship: part_of GO:0015837 ! amine transport

[Term]
id: GO:0005276
name: vesicular hydrogen:amino acid antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a vesicle membrane to the other according to the reaction: H+(in) + amino acid(out) = H+(out) + amino acid(in)." [GOC:mah, Reactome:428625]
synonym: "hydrogen:vesicular amine antiporter activity" EXACT [GOC:curators]
xref: Reactome:REACT_105739 "Vesicular inhibitory amino acid transport, Danio rerio"
xref: Reactome:REACT_110816 "Vesicular inhibitory amino acid transport, Canis familiaris"
xref: Reactome:REACT_111006 "Vesicular inhibitory amino acid transport, Gallus gallus"
xref: Reactome:REACT_112465 "Vesicular inhibitory amino acid transport, Saccharomyces cerevisiae"
xref: Reactome:REACT_113824 "Vesicular inhibitory amino acid transport, Dictyostelium discoideum"
xref: Reactome:REACT_114586 "Vesicular inhibitory amino acid transport, Arabidopsis thaliana"
xref: Reactome:REACT_114587 "Vesicular inhibitory amino acid transport, Oryza sativa"
xref: Reactome:REACT_19142 "Vesicular inhibitory amino acid transport, Homo sapiens"
xref: Reactome:REACT_31450 "Vesicular inhibitory amino acid transport, Sus scrofa"
xref: Reactome:REACT_79834 "Vesicular inhibitory amino acid transport, Caenorhabditis elegans"
xref: Reactome:REACT_82018 "Vesicular inhibitory amino acid transport, Mus musculus"
xref: Reactome:REACT_88553 "Vesicular inhibitory amino acid transport, Xenopus tropicalis"
xref: Reactome:REACT_88777 "Vesicular inhibitory amino acid transport, Drosophila melanogaster"
xref: Reactome:REACT_91700 "Vesicular inhibitory amino acid transport, Taeniopygia guttata"
xref: Reactome:REACT_98278 "Vesicular inhibitory amino acid transport, Rattus norvegicus"
is_a: GO:0005275 ! amine transmembrane transporter activity
is_a: GO:0015171 ! amino acid transmembrane transporter activity
is_a: GO:0015299 ! solute:proton antiporter activity

[Term]
id: GO:0005277
name: acetylcholine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of acetylcholine from one side of the membrane to the other. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions." [GOC:ai]
xref: Reactome:REACT_101295 "Loading of acetylcholine in synaptic vesicle, Danio rerio"
xref: Reactome:REACT_112785 "Loading of acetylcholine in synaptic vesicle, Drosophila melanogaster"
xref: Reactome:REACT_113105 "Loading of acetylcholine in synaptic vesicle, Xenopus tropicalis"
xref: Reactome:REACT_114068 "Loading of acetylcholine in synaptic vesicle, Gallus gallus"
xref: Reactome:REACT_15317 "Loading of acetylcholine in synaptic vesicle, Homo sapiens"
xref: Reactome:REACT_80134 "Loading of acetylcholine in synaptic vesicle, Rattus norvegicus"
xref: Reactome:REACT_89494 "Loading of acetylcholine in synaptic vesicle, Canis familiaris"
xref: Reactome:REACT_96366 "Loading of acetylcholine in synaptic vesicle, Bos taurus"
is_a: GO:0005326 ! neurotransmitter transporter activity
is_a: GO:0008519 ! ammonium transmembrane transporter activity
is_a: GO:1901375 ! acetate ester transmembrane transporter activity

[Term]
id: GO:0005278
name: acetylcholine:proton antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + acetylcholine(in) = H+(in) + acetylcholine(out)." [TC:2.A.1.2.13]
synonym: "acetylcholine:hydrogen antiporter activity" EXACT []
is_a: GO:0005277 ! acetylcholine transmembrane transporter activity
is_a: GO:0015299 ! solute:proton antiporter activity

[Term]
id: GO:0005280
name: hydrogen:amino acid symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + H+(out) = amino acid(in) + H+(in)." [GOC:ai]
subset: gosubset_prok
synonym: "cation/amino acid symporter" BROAD []
is_a: GO:0005416 ! cation:amino acid symporter activity
is_a: GO:0015295 ! solute:proton symporter activity

[Term]
id: GO:0005281
name: obsolete general amino acid permease activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "general amino acid permease activity" EXACT []
synonym: "general amino acid transporter" BROAD []
is_obsolete: true
replaced_by: GO:0015171

[Term]
id: GO:0005283
name: sodium:amino acid symporter activity
namespace: molecular_function
alt_id: GO:0005284
alt_id: GO:0005285
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in)." [GOC:ai]
subset: gosubset_prok
synonym: "glutamate/aspartate:sodium symporter activity" NARROW []
synonym: "insulin-activated sodium/amino acid transporter activity" NARROW []
synonym: "insulin-activated sodium:amino acid symporter activity" NARROW []
synonym: "insulin-activated sodium:amino acid transporter activity" NARROW []
synonym: "isoleucine/valine:sodium symporter activity" NARROW []
synonym: "sodium/amino acid transporter activity" BROAD []
synonym: "sodium/excitatory amino acid cotransporter activity" BROAD []
synonym: "sodium/excitatory amino acid symporter activity" EXACT []
synonym: "sodium:amino acid transporter activity" BROAD []
synonym: "threonine/serine:sodium symporter activity" RELATED []
is_a: GO:0005343 ! organic acid:sodium symporter activity
is_a: GO:0005416 ! cation:amino acid symporter activity

[Term]
id: GO:0005287
name: high-affinity basic amino acid transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of basic amino acids from one side of a membrane to the other. Acidic amino acids have a pH above 7. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport]
synonym: "high affinity basic amino acid transmembrane transporter activity" EXACT []
synonym: "high-affinity basic amino acid transporter activity" BROAD []
is_a: GO:0015174 ! basic amino acid transmembrane transporter activity

[Term]
id: GO:0005289
name: high-affinity arginine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of arginine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport]
synonym: "high affinity arginine transmembrane transporter activity" EXACT []
synonym: "high-affinity arginine transporter activity" BROAD []
is_a: GO:0005287 ! high-affinity basic amino acid transmembrane transporter activity
is_a: GO:0015181 ! arginine transmembrane transporter activity

[Term]
id: GO:0005290
name: L-histidine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "histidine/arginine/lysine/ornithine porter activity" NARROW []
synonym: "L-histidine transporter activity" BROAD []
is_a: GO:0008324 ! cation transmembrane transporter activity
is_a: GO:0015174 ! basic amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity
is_a: GO:1901474 ! azole transmembrane transporter activity
relationship: part_of GO:0089709 ! L-histidine transmembrane transport

[Term]
id: GO:0005291
name: high-affinity L-histidine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport]
synonym: "high affinity histidine permease activity" RELATED []
synonym: "high affinity L-histidine transmembrane transporter activity" EXACT []
is_a: GO:0005287 ! high-affinity basic amino acid transmembrane transporter activity
is_a: GO:0005290 ! L-histidine transmembrane transporter activity

[Term]
id: GO:0005292
name: high-affinity lysine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of lysine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport]
synonym: "high affinity lysine transmembrane transporter activity" EXACT []
synonym: "high affinity lysine transporter activity" BROAD []
is_a: GO:0005287 ! high-affinity basic amino acid transmembrane transporter activity
is_a: GO:0015189 ! L-lysine transmembrane transporter activity

[Term]
id: GO:0005294
name: neutral L-amino acid secondary active transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a neutral L-amino acid from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport]
subset: gosubset_prok
synonym: "neutral L-amino acid porter activity" RELATED []
is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0005295
name: neutral amino acid:sodium symporter activity
namespace: molecular_function
alt_id: GO:0005282
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral amino acid(out) + Na+(out) = neutral amino acid(in) + Na+(in)." [TC:2.A.23.3.1]
synonym: "neutral amino acid-sodium cotransporter" BROAD []
synonym: "sodium/neutral amino acid transporter" BROAD []
is_a: GO:0005283 ! sodium:amino acid symporter activity
is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity

[Term]
id: GO:0005297
name: hydrogen:proline symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + H+(out) = proline(in) + H+(in)." [GOC:ai]
synonym: "hydrogen/proline transporter" BROAD []
is_a: GO:0005280 ! hydrogen:amino acid symporter activity
is_a: GO:0015193 ! L-proline transmembrane transporter activity

[Term]
id: GO:0005298
name: proline:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + Na+(out) = proline(in) + Na+(in)." [TC:2.A.22.2.1]
subset: gosubset_prok
synonym: "sodium/proline symporter activity" EXACT []
xref: Reactome:REACT_20557 "PROT mediates L-proline uptake, Homo sapiens"
xref: RHEA:28970
is_a: GO:0005283 ! sodium:amino acid symporter activity
is_a: GO:0015193 ! L-proline transmembrane transporter activity
is_a: GO:0015296 ! anion:cation symporter activity

[Term]
id: GO:0005300
name: high-affinity tryptophan transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the high-affinity transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport, ISBN:0815340729]
synonym: "high-affinity tryptophan transporter activity" BROAD []
is_a: GO:0015196 ! L-tryptophan transmembrane transporter activity

[Term]
id: GO:0005301
name: obsolete valine/tyrosine/tryptophan permease activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "hydrogen/valine-tyrosine-tryptophan transporter" EXACT []
synonym: "valine/tyrosine/tryptophan permease activity" EXACT []
is_obsolete: true
consider: GO:0005302
consider: GO:0005304
consider: GO:0015196
consider: GO:0022857

[Term]
id: GO:0005302
name: L-tyrosine transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015508
def: "Enables the transfer of L-tyrosine from one side of a membrane to the other. L-tyrosine is 2-amino-3-(4-hydroxyphenyl)propanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "L-tyrosine permease activity" EXACT []
synonym: "L-tyrosine transporter activity" BROAD []
synonym: "valine/tyrosine/tryptophan permease activity" RELATED []
is_a: GO:0008324 ! cation transmembrane transporter activity
is_a: GO:0015173 ! aromatic amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity
relationship: part_of GO:0015828 ! tyrosine transport

[Term]
id: GO:0005304
name: L-valine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of L-valine from one side of a membrane to the other. L-valine is 2-amino-3-methylbutanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "isoleucine/valine:sodium symporter activity" NARROW []
synonym: "L-valine transporter activity" BROAD []
synonym: "leucine/isoleucine/valine porter activity" NARROW []
synonym: "leucine/valine/isoleucine permease activity" NARROW []
synonym: "valine/tyrosine/tryptophan permease activity" NARROW []
is_a: GO:0008324 ! cation transmembrane transporter activity
is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity
is_a: GO:0015658 ! branched-chain amino acid transmembrane transporter activity
relationship: part_of GO:1903785 ! L-valine transmembrane transport

[Term]
id: GO:0005307
name: choline:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: choline(out) + Na+(out) = choline(in) + Na+(in)." [TC:2.A.22.3.5]
synonym: "sodium/choline symporter activity" EXACT []
is_a: GO:0015220 ! choline transmembrane transporter activity
is_a: GO:0015370 ! solute:sodium symporter activity

[Term]
id: GO:0005308
name: creatine transmembrane transporter activity
namespace: molecular_function
def: "Enables the directed movement of creatine across a membrane. Creatine is a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle." [GOC:ai]
is_a: GO:0015171 ! amino acid transmembrane transporter activity
is_a: GO:0051184 ! cofactor transporter activity
is_a: GO:0072349 ! modified amino acid transmembrane transporter activity
relationship: part_of GO:1902598 ! creatine transmembrane transport

[Term]
id: GO:0005309
name: creatine:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: creatine(out) + Na+(out) = creatine(in) + Na+(in)." [TC:2.A.22.3.4]
synonym: "sodium/chloride-dependent creatine transporter" BROAD []
xref: Reactome:REACT_100722 "Creatine transport across the plasma membrane, Danio rerio"
xref: Reactome:REACT_106974 "Creatine transport across the plasma membrane, Rattus norvegicus"
xref: Reactome:REACT_11191 "Creatine transport across the plasma membrane, Homo sapiens"
xref: Reactome:REACT_112702 "Creatine transport across the plasma membrane, Gallus gallus"
xref: Reactome:REACT_113563 "Creatine transport across the plasma membrane, Taeniopygia guttata"
xref: Reactome:REACT_115072 "Creatine transport across the plasma membrane, Staphylococcus aureus N315"
xref: Reactome:REACT_115159 "Creatine transport across the plasma membrane, Sus scrofa"
xref: Reactome:REACT_28741 "Creatine transport across the plasma membrane, Xenopus tropicalis"
xref: Reactome:REACT_29363 "Creatine transport across the plasma membrane, Canis familiaris"
xref: Reactome:REACT_31852 "Creatine transport across the plasma membrane, Mus musculus"
xref: Reactome:REACT_83071 "Creatine transport across the plasma membrane, Bos taurus"
is_a: GO:0005308 ! creatine transmembrane transporter activity
is_a: GO:0005343 ! organic acid:sodium symporter activity
is_a: GO:0015296 ! anion:cation symporter activity

[Term]
id: GO:0005310
name: dicarboxylic acid transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0005312
alt_id: GO:0015365
def: "Enables the transfer of dicarboxylic acids from one side of the membrane to the other. A dicarboxylic acid is an organic acid with two COOH groups." [GOC:ai]
subset: gosubset_prok
synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity" RELATED []
synonym: "dicarboxylate carrier" NARROW []
synonym: "dicarboxylic acid permease activity" RELATED []
synonym: "sodium:dicarboxylate/tricarboxylate symporter activity" NARROW []
xref: Reactome:REACT_109430 "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix], Rattus norvegicus"
xref: Reactome:REACT_110674 "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix], Caenorhabditis elegans"
xref: Reactome:REACT_112858 "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix], Oryza sativa"
xref: Reactome:REACT_113407 "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix], Drosophila melanogaster"
xref: Reactome:REACT_113778 "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix], Arabidopsis thaliana"
xref: Reactome:REACT_115641 "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix], Gallus gallus"
xref: Reactome:REACT_115667 "Sulfate is exported to the cytosol in exchange for dicarboxylate, Homo sapiens"
xref: Reactome:REACT_14803 "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix], Homo sapiens"
xref: Reactome:REACT_77841 "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix], Mus musculus"
xref: Reactome:REACT_86588 "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix], Saccharomyces cerevisiae"
xref: Reactome:REACT_89379 "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix], Xenopus tropicalis"
xref: Reactome:REACT_89560 "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix], Taeniopygia guttata"
xref: Reactome:REACT_90846 "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix], Bos taurus"
xref: Reactome:REACT_91235 "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix], Danio rerio"
xref: Reactome:REACT_96545 "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix], Gallus gallus"
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity
relationship: part_of GO:0006835 ! dicarboxylic acid transport

[Term]
id: GO:0005311
name: obsolete sodium:dicarboxylate/tricarboxylate symporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (dicarboxylate or tricarboxylate)(out) + Na+(out) = (dicarboxylate or tricarboxylate)(in) + Na+(in)." [TC:2.A.47.1.5]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "sodium:dicarboxylate/tricarboxylate cotransporter activity" BROAD []
synonym: "sodium:dicarboxylate/tricarboxylate symporter activity" EXACT []
is_obsolete: true
consider: GO:0005310
consider: GO:0005343
consider: GO:0015142

[Term]
id: GO:0005313
name: L-glutamate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of L-glutamate from one side of a membrane to the other. L-glutamate is the anion of 2-aminopentanedioic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "glutamate/aspartate porter activity" NARROW []
synonym: "glutamate/aspartate:sodium symporter activity" NARROW []
synonym: "L-glutamate transporter activity" BROAD []
xref: Reactome:REACT_100347 "L-Glutamate loading of synaptic vesicle, Rattus norvegicus"
xref: Reactome:REACT_101701 "L-Glutamate loading of synaptic vesicle, Sus scrofa"
xref: Reactome:REACT_108641 "Vesicular glutamate transport, Caenorhabditis elegans"
xref: Reactome:REACT_108885 "Vesicular glutamate transport, Mus musculus"
xref: Reactome:REACT_112266 "Vesicular glutamate transport, Staphylococcus aureus N315"
xref: Reactome:REACT_112417 "Vesicular glutamate transport, Arabidopsis thaliana"
xref: Reactome:REACT_113125 "Vesicular glutamate transport, Oryza sativa"
xref: Reactome:REACT_113198 "Vesicular glutamate transport, Escherichia coli"
xref: Reactome:REACT_114619 "L-Glutamate loading of synaptic vesicle, Drosophila melanogaster"
xref: Reactome:REACT_115281 "L-Glutamate loading of synaptic vesicle, Caenorhabditis elegans"
xref: Reactome:REACT_12503 "L-Glutamate loading of synaptic vesicle, Homo sapiens"
xref: Reactome:REACT_19233 "Vesicular glutamate transport, Homo sapiens"
xref: Reactome:REACT_28272 "L-Glutamate loading of synaptic vesicle, Danio rerio"
xref: Reactome:REACT_33403 "Vesicular glutamate transport, Canis familiaris"
xref: Reactome:REACT_34581 "Vesicular glutamate transport, Danio rerio"
xref: Reactome:REACT_82558 "Vesicular glutamate transport, Rattus norvegicus"
xref: Reactome:REACT_83766 "Vesicular glutamate transport, Drosophila melanogaster"
xref: Reactome:REACT_83949 "L-Glutamate loading of synaptic vesicle, Bos taurus"
xref: Reactome:REACT_85542 "L-Glutamate loading of synaptic vesicle, Mus musculus"
xref: Reactome:REACT_92439 "Vesicular glutamate transport, Xenopus tropicalis"
xref: Reactome:REACT_94935 "Vesicular glutamate transport, Taeniopygia guttata"
xref: Reactome:REACT_95485 "L-Glutamate loading of synaptic vesicle, Xenopus tropicalis"
xref: Reactome:REACT_96114 "Vesicular glutamate transport, Sus scrofa"
xref: Reactome:REACT_97308 "L-Glutamate loading of synaptic vesicle, Canis familiaris"
xref: Reactome:REACT_98064 "Vesicular glutamate transport, Bos taurus"
xref: Reactome:REACT_99217 "Vesicular glutamate transport, Gallus gallus"
is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity
is_a: GO:0015172 ! acidic amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity
relationship: part_of GO:0089711 ! L-glutamate transmembrane transport

[Term]
id: GO:0005314
name: high-affinity glutamate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + H+(out) = glutamate(in) + H+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [TC:2.A.3.10.5]
synonym: "high-affinity glutamate transporter activity" BROAD []
xref: Reactome:REACT_100375 "Glutamate transport, Taeniopygia guttata"
xref: Reactome:REACT_100414 "Glutamate transport, Caenorhabditis elegans"
xref: Reactome:REACT_107737 "Glutamate transport, Sus scrofa"
xref: Reactome:REACT_112875 "Glutamate transport, Drosophila melanogaster"
xref: Reactome:REACT_114169 "Glutamate transport, Staphylococcus aureus N315"
xref: Reactome:REACT_19362 "Glutamate transport, Homo sapiens"
xref: Reactome:REACT_29726 "Glutamate transport, Mus musculus"
xref: Reactome:REACT_34503 "Glutamate transport, Gallus gallus"
xref: Reactome:REACT_34507 "Glutamate transport, Danio rerio"
xref: Reactome:REACT_82059 "Glutamate transport, Rattus norvegicus"
xref: Reactome:REACT_86694 "Glutamate transport, Bos taurus"
xref: Reactome:REACT_89585 "Glutamate transport, Xenopus tropicalis"
xref: Reactome:REACT_89654 "Glutamate transport, Escherichia coli"
xref: Reactome:REACT_93890 "Glutamate transport, Canis familiaris"
is_a: GO:0005313 ! L-glutamate transmembrane transporter activity
is_a: GO:0015370 ! solute:sodium symporter activity

[Term]
id: GO:0005315
name: inorganic phosphate transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0005317
def: "Enables the transfer of a inorganic phosphate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport]
subset: gosubset_prok
is_a: GO:0015291 ! secondary active transmembrane transporter activity
is_a: GO:1901677 ! phosphate transmembrane transporter activity

[Term]
id: GO:0005316
name: high-affinity inorganic phosphate:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: HPO42-(out) + Na+(out) = HPO42-(in) + Na+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [TC:2.A.20.2.2]
synonym: "high affinity inorganic phosphate:sodium symporter activity" EXACT []
synonym: "sodium/phosphate cotransporter activity" BROAD []
is_a: GO:0005436 ! sodium:phosphate symporter activity
is_a: GO:0015370 ! solute:sodium symporter activity

[Term]
id: GO:0005318
name: obsolete phosphate:hydrogen symporter
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
synonym: "phosphate:hydrogen symporter" EXACT []
synonym: "phosphate:proton symporter activity" EXACT []
is_obsolete: true
consider: GO:0015317

[Term]
id: GO:0005319
name: lipid transporter activity
namespace: molecular_function
def: "Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]
subset: gosubset_prok
synonym: "apolipoprotein" RELATED []
synonym: "lipophorin" NARROW []
xref: Reactome:REACT_107441 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex, Danio rerio"
xref: Reactome:REACT_111067 "ABCAs mediate lipid efflux, Homo sapiens"
xref: Reactome:REACT_111169 "ABCAs mediate lipid influx, Homo sapiens"
xref: Reactome:REACT_111998 "ABCAs mediate lipid efflux, Xenopus tropicalis"
xref: Reactome:REACT_112083 "ABCAs mediate lipid efflux, Mycobacterium tuberculosis"
xref: Reactome:REACT_112225 "ABCAs mediate lipid influx, Xenopus tropicalis"
xref: Reactome:REACT_112273 "ABCAs mediate lipid influx, Canis familiaris"
xref: Reactome:REACT_112420 "ABCAs mediate lipid efflux, Sus scrofa"
xref: Reactome:REACT_112734 "ABCAs mediate lipid influx, Mus musculus"
xref: Reactome:REACT_112793 "ABCAs mediate lipid influx, Drosophila melanogaster"
xref: Reactome:REACT_112990 "ABCAs mediate lipid efflux, Drosophila melanogaster"
xref: Reactome:REACT_113370 "ABCAs mediate lipid influx, Mycobacterium tuberculosis"
xref: Reactome:REACT_113696 "ABCAs mediate lipid influx, Taeniopygia guttata"
xref: Reactome:REACT_113865 "ABCAs mediate lipid influx, Danio rerio"
xref: Reactome:REACT_113910 "ABCAs mediate lipid efflux, Canis familiaris"
xref: Reactome:REACT_114060 "ABCAs mediate lipid efflux, Bos taurus"
xref: Reactome:REACT_114336 "ABCAs mediate lipid efflux, Danio rerio"
xref: Reactome:REACT_114700 "ABCAs mediate lipid efflux, Mus musculus"
xref: Reactome:REACT_114808 "ABCAs mediate lipid efflux, Rattus norvegicus"
xref: Reactome:REACT_114875 "ABCAs mediate lipid influx, Rattus norvegicus"
xref: Reactome:REACT_114929 "ABCAs mediate lipid influx, Bos taurus"
xref: Reactome:REACT_115011 "ABCAs mediate lipid influx, Sus scrofa"
xref: Reactome:REACT_115076 "ABCAs mediate lipid influx, Gallus gallus"
xref: Reactome:REACT_115091 "ABCAs mediate lipid efflux, Gallus gallus"
xref: Reactome:REACT_115251 "ABCAs mediate lipid efflux, Taeniopygia guttata"
xref: Reactome:REACT_30241 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex, Rattus norvegicus"
xref: Reactome:REACT_6908 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex, Homo sapiens"
xref: Reactome:REACT_79155 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex, Canis familiaris"
xref: Reactome:REACT_81934 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex, Xenopus tropicalis"
xref: Reactome:REACT_84235 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex, Mus musculus"
xref: Reactome:REACT_89204 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex, Gallus gallus"
xref: Reactome:REACT_95856 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex, Bos taurus"
xref: Reactome:REACT_98397 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex, Taeniopygia guttata"
is_a: GO:0022892 ! substrate-specific transporter activity
relationship: part_of GO:0006869 ! lipid transport

[Term]
id: GO:0005320
name: obsolete apolipoprotein
namespace: molecular_function
alt_id: GO:0015907
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it does not represent a molecular function.
synonym: "apolipoprotein" EXACT []
is_obsolete: true
consider: GO:0005319

[Term]
id: GO:0005321
name: obsolete high-density lipoprotein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it does not represent a molecular function.
synonym: "HDL" EXACT []
synonym: "high-density lipoprotein" EXACT []
is_obsolete: true
replaced_by: GO:0005319

[Term]
id: GO:0005322
name: obsolete low-density lipoprotein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it does not represent a molecular function.
synonym: "LDL" EXACT []
synonym: "low-density lipoprotein" EXACT []
is_obsolete: true
replaced_by: GO:0005319

[Term]
id: GO:0005323
name: obsolete very-low-density lipoprotein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it does not represent a molecular function.
synonym: "very-low-density lipoprotein" EXACT []
synonym: "VLDL" EXACT []
is_obsolete: true
replaced_by: GO:0005319

[Term]
id: GO:0005324
name: long-chain fatty acid transporter activity
namespace: molecular_function
def: "Enables the directed movement of long-chain fatty acids into, out of or within a cell, or between cells. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [CHEBI:15904, ISBN:0198506732]
subset: gosubset_prok
synonym: "plasma membrane long-chain fatty acid transporter" NARROW []
xref: Reactome:REACT_101477 "ABCD1/D2/D3 mediate long chain fatty acid transport in to peroxisomes, Drosophila melanogaster"
xref: Reactome:REACT_101752 "ABCD1/D2/D3 mediate long chain fatty acid transport in to peroxisomes, Saccharomyces cerevisiae"
xref: Reactome:REACT_106740 "ABCD1/D2/D3 mediate long chain fatty acid transport in to peroxisomes, Mus musculus"
xref: Reactome:REACT_112344 "ABCD1/D2/D3 mediate long chain fatty acid transport in to peroxisomes, Escherichia coli"
xref: Reactome:REACT_113806 "ABCD1/D2/D3 mediate long chain fatty acid transport in to peroxisomes, Mycobacterium tuberculosis"
xref: Reactome:REACT_15322 "ABCD1/D2/D3 mediate long chain fatty acid transport in to peroxisomes, Homo sapiens"
xref: Reactome:REACT_29426 "ABCD1/D2/D3 mediate long chain fatty acid transport in to peroxisomes, Taeniopygia guttata"
xref: Reactome:REACT_34095 "ABCD1/D2/D3 mediate long chain fatty acid transport in to peroxisomes, Caenorhabditis elegans"
xref: Reactome:REACT_34135 "ABCD1/D2/D3 mediate long chain fatty acid transport in to peroxisomes, Danio rerio"
xref: Reactome:REACT_34416 "ABCD1/D2/D3 mediate long chain fatty acid transport in to peroxisomes, Bos taurus"
xref: Reactome:REACT_59791 "ABCD1/D2/D3 mediate long chain fatty acid transport in to peroxisomes, Sus scrofa"
xref: Reactome:REACT_78591 "ABCD1/D2/D3 mediate long chain fatty acid transport in to peroxisomes, Canis familiaris"
xref: Reactome:REACT_85267 "ABCD1/D2/D3 mediate long chain fatty acid transport in to peroxisomes, Gallus gallus"
xref: Reactome:REACT_86284 "ABCD1/D2/D3 mediate long chain fatty acid transport in to peroxisomes, Xenopus tropicalis"
xref: Reactome:REACT_91468 "ABCD1/D2/D3 mediate long chain fatty acid transport in to peroxisomes, Rattus norvegicus"
xref: Reactome:REACT_95170 "ABCD1/D2/D3 mediate long chain fatty acid transport in to peroxisomes, Dictyostelium discoideum"
is_a: GO:0015245 ! fatty acid transporter activity
relationship: part_of GO:0015909 ! long-chain fatty acid transport

[Term]
id: GO:0005325
name: peroxisomal fatty-acyl-CoA transporter activity
namespace: molecular_function
alt_id: GO:0008562
def: "Catalysis of the reaction: ATP + H2O + fatty acyl CoA(cis) = ADP + phosphate + fatty acyl CoA(trans). The transport of fatty acyl CoA into and out of peroxisomes." [EC:3.6.3.47]
synonym: "ATP phosphohydrolase (fatty-acyl-CoA-transporting)" EXACT [EC:3.6.3.47]
synonym: "fatty-acyl-CoA-transporting ATPase" BROAD []
synonym: "peroxisomal fatty acyl CoA transporter activity" EXACT [GOC:curators]
xref: EC:3.6.3.47
xref: Reactome:REACT_104192 "Peroxisomal uptake of very long-chain fatty acyl CoA, Bos taurus"
xref: Reactome:REACT_112629 "Peroxisomal uptake of very long-chain fatty acyl CoA, Escherichia coli"
xref: Reactome:REACT_113055 "Peroxisomal uptake of very long-chain fatty acyl CoA, Mycobacterium tuberculosis"
xref: Reactome:REACT_16917 "Peroxisomal uptake of very long-chain fatty acyl CoA, Homo sapiens"
xref: Reactome:REACT_28404 "Peroxisomal uptake of very long-chain fatty acyl CoA, Danio rerio"
xref: Reactome:REACT_33396 "Peroxisomal uptake of very long-chain fatty acyl CoA, Sus scrofa"
xref: Reactome:REACT_79138 "Peroxisomal uptake of very long-chain fatty acyl CoA, Canis familiaris"
xref: Reactome:REACT_80384 "Peroxisomal uptake of very long-chain fatty acyl CoA, Drosophila melanogaster"
xref: Reactome:REACT_85101 "Peroxisomal uptake of very long-chain fatty acyl CoA, Dictyostelium discoideum"
xref: Reactome:REACT_87966 "Peroxisomal uptake of very long-chain fatty acyl CoA, Xenopus tropicalis"
xref: Reactome:REACT_94559 "Peroxisomal uptake of very long-chain fatty acyl CoA, Mus musculus"
xref: Reactome:REACT_94647 "Peroxisomal uptake of very long-chain fatty acyl CoA, Caenorhabditis elegans"
xref: Reactome:REACT_96151 "Peroxisomal uptake of very long-chain fatty acyl CoA, Saccharomyces cerevisiae"
xref: Reactome:REACT_99381 "Peroxisomal uptake of very long-chain fatty acyl CoA, Rattus norvegicus"
is_a: GO:0005324 ! long-chain fatty acid transporter activity
is_a: GO:0015607 ! fatty-acyl-CoA transporter activity
relationship: part_of GO:0015910 ! peroxisomal long-chain fatty acid import

[Term]
id: GO:0005326
name: neurotransmitter transporter activity
namespace: molecular_function
def: "Enables the directed movement of a neurotransmitter into, out of or within a cell, or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai, ISBN:0198506732]
subset: gosubset_prok
synonym: "neurotransmitter transmembrane transporter activity" EXACT [GOC:mah]
xref: Reactome:REACT_112831 "Uptake of Noradrenaline, Xenopus tropicalis"
xref: Reactome:REACT_114411 "Uptake of Noradrenaline, Danio rerio"
xref: Reactome:REACT_15341 "Noradrenaline clearance from the synaptic cleft, Homo sapiens"
xref: Reactome:REACT_15472 "Uptake of Noradrenaline, Homo sapiens"
xref: Reactome:REACT_34067 "Uptake of Noradrenaline, Taeniopygia guttata"
xref: Reactome:REACT_69625 "Uptake of Noradrenaline, Gallus gallus"
xref: Reactome:REACT_78567 "Uptake of Noradrenaline, Sus scrofa"
xref: Reactome:REACT_78577 "Uptake of Noradrenaline, Canis familiaris"
xref: Reactome:REACT_87416 "Uptake of Noradrenaline, Rattus norvegicus"
xref: Reactome:REACT_91117 "Uptake of Noradrenaline, Mus musculus"
xref: Reactome:REACT_95064 "Uptake of Noradrenaline, Bos taurus"
is_a: GO:0005215 ! transporter activity
relationship: part_of GO:0006836 ! neurotransmitter transport

[Term]
id: GO:0005328
name: neurotransmitter:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in)." [TC:2.A.22.-.-]
subset: gosubset_prok
synonym: "sodium/neurotransmitter symporter activity" EXACT []
is_a: GO:0005326 ! neurotransmitter transporter activity
is_a: GO:0015370 ! solute:sodium symporter activity

[Term]
id: GO:0005329
name: dopamine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of dopamine from one side of the membrane to the other. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:ai]
is_a: GO:0008504 ! monoamine transmembrane transporter activity
is_a: GO:0008519 ! ammonium transmembrane transporter activity
is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity

[Term]
id: GO:0005330
name: dopamine:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dopamine(out) + Na+(out) = dopamine(in) + Na+(in)." [TC:2.A.22.1.3]
synonym: "sodium/dopamine symporter activity" EXACT []
is_a: GO:0005328 ! neurotransmitter:sodium symporter activity
is_a: GO:0005329 ! dopamine transmembrane transporter activity

[Term]
id: GO:0005332
name: gamma-aminobutyric acid:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + Na+(out) = gamma-aminobutyric acid(in) + Na+(in)." [TC:2.A.22.3.2]
comment: See also the molecular function term 'neurotransmitter:sodium symporter activity ; GO:0005328'.
synonym: "4-aminobutanoate:sodium symporter activity" EXACT []
synonym: "4-aminobutyrate:sodium symporter activity" EXACT []
synonym: "betaine/GABA:sodium symporter activity" EXACT []
synonym: "GABA:sodium symporter activity" EXACT []
synonym: "sodium/chloride-dependent GABA transporter activity" BROAD []
xref: Reactome:REACT_20659 "GAT1-3 mediate Na+/Cl- dependent GABA transport, Homo sapiens"
is_a: GO:0005283 ! sodium:amino acid symporter activity
is_a: GO:0015185 ! gamma-aminobutyric acid transmembrane transporter activity
is_a: GO:0015296 ! anion:cation symporter activity

[Term]
id: GO:0005333
name: norepinephrine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of norepinephrine from one side of the membrane to the other. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine." [ISBN:0198506732]
synonym: "levarterenol transporter activity" EXACT []
synonym: "noradrenaline transporter activity" EXACT []
xref: Wikipedia:Norepinephrine_transporter
is_a: GO:0008504 ! monoamine transmembrane transporter activity
is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity

[Term]
id: GO:0005334
name: norepinephrine:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: norepinephrine(out) + Na+(out) = norepinephrine(in) + Na+(in)." [TC:2.A.22.1.2]
synonym: "noradrenaline:sodium symporter activity" EXACT []
synonym: "sodium/norepinephrine symporter activity" EXACT []
xref: Reactome:REACT_20592 "NAT1 mediates norepinephrine uptake, Homo sapiens"
is_a: GO:0005328 ! neurotransmitter:sodium symporter activity
is_a: GO:0005333 ! norepinephrine transmembrane transporter activity

[Term]
id: GO:0005335
name: serotonin:sodium symporter activity
namespace: molecular_function
alt_id: GO:0005336
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: serotonin(out) + Na+(out) = serotonin(in) + Na+(in)." [TC:2.A.22.1.1]
synonym: "sodium/serotonin symporter activity" EXACT []
is_a: GO:0005328 ! neurotransmitter:sodium symporter activity
is_a: GO:0015222 ! serotonin transmembrane transporter activity

[Term]
id: GO:0005337
name: nucleoside transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other." [GOC:ai]
subset: gosubset_prok
synonym: "intracellular nucleoside transmembrane transporter activity" NARROW []
xref: Reactome:REACT_102693 "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2, Sus scrofa"
xref: Reactome:REACT_103566 "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1, Sus scrofa"
xref: Reactome:REACT_104920 "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1, Saccharomyces cerevisiae"
xref: Reactome:REACT_105065 "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1, Taeniopygia guttata"
xref: Reactome:REACT_1054 "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1, Homo sapiens"
xref: Reactome:REACT_106060 "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2, Bos taurus"
xref: Reactome:REACT_108963 "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2, Bos taurus"
xref: Reactome:REACT_110669 "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1, Taeniopygia guttata"
xref: Reactome:REACT_111027 "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2, Canis familiaris"
xref: Reactome:REACT_112137 "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2, Dictyostelium discoideum"
xref: Reactome:REACT_112369 "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1, Dictyostelium discoideum"
xref: Reactome:REACT_112717 "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1, Dictyostelium discoideum"
xref: Reactome:REACT_112837 "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1, Drosophila melanogaster"
xref: Reactome:REACT_113428 "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2, Dictyostelium discoideum"
xref: Reactome:REACT_113840 "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2, Drosophila melanogaster"
xref: Reactome:REACT_114976 "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2, Drosophila melanogaster"
xref: Reactome:REACT_115150 "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1, Drosophila melanogaster"
xref: Reactome:REACT_1268 "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2, Homo sapiens"
xref: Reactome:REACT_22188 "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4, Homo sapiens"
xref: Reactome:REACT_22212 "Equilibrative transport (export) of nucleosides and adenine by solute carrier family 29 (nucleoside transporters), member 3, Homo sapiens"
xref: Reactome:REACT_22315 "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4, Homo sapiens"
xref: Reactome:REACT_22395 "Equilibrative transport (import) of nucleosides and adenine by solute carrier family 29 (nucleoside transporters), member 3, Homo sapiens"
xref: Reactome:REACT_30936 "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1, Danio rerio"
xref: Reactome:REACT_77305 "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1, Rattus norvegicus"
xref: Reactome:REACT_77329 "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1, Gallus gallus"
xref: Reactome:REACT_78456 "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2, Canis familiaris"
xref: Reactome:REACT_78850 "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1, Bos taurus"
xref: Reactome:REACT_79532 "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2, Mus musculus"
xref: Reactome:REACT_79741 "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1, Gallus gallus"
xref: Reactome:REACT_80101 "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2, Rattus norvegicus"
xref: Reactome:REACT_806 "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1, Homo sapiens"
xref: Reactome:REACT_80713 "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2, Xenopus tropicalis"
xref: Reactome:REACT_80971 "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1, Mus musculus"
xref: Reactome:REACT_81421 "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2, Saccharomyces cerevisiae"
xref: Reactome:REACT_82429 "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2, Danio rerio"
xref: Reactome:REACT_82499 "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2, Mus musculus"
xref: Reactome:REACT_86195 "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1, Sus scrofa"
xref: Reactome:REACT_87106 "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1, Saccharomyces cerevisiae"
xref: Reactome:REACT_90634 "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1, Mus musculus"
xref: Reactome:REACT_92112 "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2, Danio rerio"
xref: Reactome:REACT_93226 "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1, Bos taurus"
xref: Reactome:REACT_94310 "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2, Xenopus tropicalis"
xref: Reactome:REACT_94316 "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2, Saccharomyces cerevisiae"
xref: Reactome:REACT_95776 "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1, Danio rerio"
xref: Reactome:REACT_958 "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2, Homo sapiens"
xref: Reactome:REACT_95962 "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1, Rattus norvegicus"
xref: Reactome:REACT_98540 "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2, Rattus norvegicus"
xref: Reactome:REACT_99434 "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2, Sus scrofa"
is_a: GO:0015932 ! nucleobase-containing compound transmembrane transporter activity
is_a: GO:1901505 ! carbohydrate derivative transporter activity
relationship: part_of GO:1901642 ! nucleoside transmembrane transport

[Term]
id: GO:0005338
name: nucleotide-sugar transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0005339
def: "Enables the transfer of a nucleotide-sugar from one side of the membrane to the other. A nucleotide-sugar is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:ai, GOC:mtg_transport, ISBN:0815340729, PMID:15034926]
xref: Reactome:REACT_22122 "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP, Homo sapiens"
xref: Reactome:REACT_22287 "SLC35D2 mediates the antiport of UDP-sugars in exchange for UMP, Homo sapiens"
is_a: GO:0015215 ! nucleotide transmembrane transporter activity
is_a: GO:1901505 ! carbohydrate derivative transporter activity

[Term]
id: GO:0005340
name: nucleotide-sulfate transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0005341
def: "Enables the transfer of nucleotide-sulfate from one side of a membrane to the other." [GOC:mtg_transport]
synonym: "nucleotide-sulphate transporter activity" EXACT []
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015116 ! sulfate transmembrane transporter activity
is_a: GO:0015215 ! nucleotide transmembrane transporter activity

[Term]
id: GO:0005342
name: organic acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of organic acids, any acidic compound containing carbon in covalent linkage, from one side of the membrane to the other." [ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity
relationship: part_of GO:1903825 ! organic acid transmembrane transport

[Term]
id: GO:0005343
name: organic acid:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organic acid(out) + Na+(out) = organic acid(in) + Na+(in)." [TC:2.A.28.1.1]
subset: gosubset_prok
synonym: "sodium/chloride-dependent organic acid cotransporter activity" RELATED []
synonym: "sodium:dicarboxylate/tricarboxylate symporter activity" NARROW []
is_a: GO:0005342 ! organic acid transmembrane transporter activity
is_a: GO:0015370 ! solute:sodium symporter activity

[Term]
id: GO:0005344
name: oxygen transporter activity
namespace: molecular_function
alt_id: GO:0015033
def: "Enables the directed movement of oxygen into, out of or within a cell, or between cells." [GOC:ai]
subset: gosubset_prok
synonym: "globin" NARROW []
synonym: "hemerythrin" NARROW []
synonym: "hemocyanin" NARROW []
synonym: "oxygen-carrying" NARROW []
is_a: GO:0022892 ! substrate-specific transporter activity
relationship: part_of GO:0015671 ! oxygen transport

[Term]
id: GO:0005345
name: purine nucleobase transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other." [CHEBI:26386, ISBN:0198506732]
subset: gosubset_prok
synonym: "purine base transmembrane transporter activity" EXACT [GOC:go_curators]
synonym: "purine transmembrane transporter activity" RELATED [GOC:curators]
is_a: GO:0015205 ! nucleobase transmembrane transporter activity
relationship: part_of GO:1904823 ! purine nucleobase transmembrane transport

[Term]
id: GO:0005346
name: purine ribonucleotide transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a purine ribonucleotide, any compound consisting of a purine ribonucleoside (a purine organic base attached to a ribose sugar) esterified with (ortho)phosphate, from one side of a membrane to the other." [GOC:ai]
is_a: GO:0015216 ! purine nucleotide transmembrane transporter activity
is_a: GO:1901505 ! carbohydrate derivative transporter activity

[Term]
id: GO:0005347
name: ATP transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0005348
def: "Enables the transfer of ATP, adenosine triphosphate, from one side of a membrane to the other." [GOC:ai]
is_a: GO:0000295 ! adenine nucleotide transmembrane transporter activity
is_a: GO:0005346 ! purine ribonucleotide transmembrane transporter activity
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015211 ! purine nucleoside transmembrane transporter activity
relationship: part_of GO:0015867 ! ATP transport

[Term]
id: GO:0005350
name: pyrimidine nucleobase transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of pyrimidine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other." [CHEBI:26432, GOC:ai]
subset: gosubset_prok
synonym: "pyrimidine base transmembrane transporter activity" EXACT [GOC:go_curators]
synonym: "pyrimidine transmembrane transporter activity" RELATED [GOC:curators]
is_a: GO:0015205 ! nucleobase transmembrane transporter activity
relationship: part_of GO:0015855 ! pyrimidine nucleobase transport
relationship: part_of GO:0072531 ! pyrimidine-containing compound transmembrane transport

[Term]
id: GO:0005351
name: sugar:proton symporter activity
namespace: molecular_function
alt_id: GO:0005403
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in)." [TC:2.A.1.1.-]
subset: gosubset_prok
synonym: "cation/sugar symporter activity" BROAD []
synonym: "hydrogen:sugar symporter activity" EXACT []
synonym: "hydrogen:sugar transporter activity" BROAD []
synonym: "proton:sugar symporter activity" EXACT []
synonym: "sugar porter activity" RELATED []
synonym: "sugar transporter" BROAD []
synonym: "sugar:hydrogen ion symporter activity" EXACT []
synonym: "sugar:hydrogen symporter activity" EXACT []
is_a: GO:0005402 ! cation:sugar symporter activity
is_a: GO:0015295 ! solute:proton symporter activity

[Term]
id: GO:0005352
name: alpha-glucoside:proton symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alpha-glucoside(out) + H+(out) = alpha-glucoside(in) + H+(in). Alpha-glucosides include trehalose, maltose, turanose, isomaltose, alpha-methylglucoside, maltotriose, palatinose, trehalose and melezitose." [TC:2.A.1.1.11]
synonym: "alpha-glucoside:hydrogen symporter activity" EXACT []
synonym: "general alpha-glucoside transporter activity" BROAD []
synonym: "general alpha-glucoside:hydrogen symporter activity" EXACT []
synonym: "general alpha-glucoside:proton symporter activity" EXACT []
is_a: GO:0015151 ! alpha-glucoside transmembrane transporter activity
is_a: GO:0015294 ! solute:cation symporter activity

[Term]
id: GO:0005353
name: fructose transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015585
alt_id: GO:0019192
def: "Enables the transfer of fructose from one side of the membrane to the other. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "fructose permease activity" EXACT []
synonym: "fructose porter activity" EXACT []
xref: Reactome:REACT_107432 "Transport (influx) of fructose by GLUT5, Taeniopygia guttata"
xref: Reactome:REACT_108144 "Transport (influx) of fructose by GLUT5, Xenopus tropicalis"
xref: Reactome:REACT_112097 "Transport (influx) of fructose by GLUT5, Mycobacterium tuberculosis"
xref: Reactome:REACT_113496 "Transport (influx) of fructose by GLUT5, Dictyostelium discoideum"
xref: Reactome:REACT_113519 "Transport (influx) of fructose by GLUT5, Oryza sativa"
xref: Reactome:REACT_114250 "Transport (influx) of fructose by GLUT5, Plasmodium falciparum"
xref: Reactome:REACT_114334 "Transport (influx) of fructose by GLUT5, Arabidopsis thaliana"
xref: Reactome:REACT_28659 "Transport (influx) of fructose by GLUT5, Mus musculus"
xref: Reactome:REACT_34761 "Transport (influx) of fructose by GLUT5, Rattus norvegicus"
xref: Reactome:REACT_79205 "Transport (influx) of fructose by GLUT5, Bos taurus"
xref: Reactome:REACT_88249 "Transport (influx) of fructose by GLUT5, Canis familiaris"
xref: Reactome:REACT_89328 "Transport (influx) of fructose by GLUT5, Danio rerio"
xref: Reactome:REACT_9449 "Transport (influx) of fructose by GLUT5, Homo sapiens"
xref: Reactome:REACT_94807 "Transport (influx) of fructose by GLUT5, Gallus gallus"
is_a: GO:0015149 ! hexose transmembrane transporter activity
relationship: part_of GO:0015755 ! fructose transport

[Term]
id: GO:0005354
name: galactose transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of galactose from one side of the membrane to the other. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "galactose/glucose (methylgalactoside) porter activity" RELATED []
is_a: GO:0015149 ! hexose transmembrane transporter activity
relationship: part_of GO:0015757 ! galactose transport

[Term]
id: GO:0005355
name: glucose transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015579
def: "Enables the transfer of the hexose monosaccharide glucose from one side of the membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "galactose/glucose (methylgalactoside) porter activity" RELATED []
synonym: "glucose permease activity" EXACT []
synonym: "lactose/glucose efflux transporter activity" NARROW []
xref: Reactome:REACT_112687 "alpha-D-glucose (extracellular) <=> alpha-D-glucose (cytosol), Oryza sativa"
xref: Reactome:REACT_113469 "alpha-D-glucose (extracellular) <=> alpha-D-glucose (cytosol), Dictyostelium discoideum"
xref: Reactome:REACT_114420 "alpha-D-glucose (extracellular) <=> alpha-D-glucose (cytosol), Plasmodium falciparum"
xref: Reactome:REACT_114521 "alpha-D-glucose (extracellular) <=> alpha-D-glucose (cytosol), Caenorhabditis elegans"
xref: Reactome:REACT_114545 "alpha-D-glucose (extracellular) <=> alpha-D-glucose (cytosol), Drosophila melanogaster"
xref: Reactome:REACT_114814 "alpha-D-glucose (extracellular) <=> alpha-D-glucose (cytosol), Arabidopsis thaliana"
xref: Reactome:REACT_114865 "alpha-D-glucose (extracellular) <=> alpha-D-glucose (cytosol), Mycobacterium tuberculosis"
xref: Reactome:REACT_115669 "glucose [extracellular] <=> glucose [cytosol], Gallus gallus"
xref: Reactome:REACT_116070 "glucose [cytosol] <=> glucose [extracellular], Gallus gallus"
xref: Reactome:REACT_1338 "alpha-D-glucose (extracellular) <=> alpha-D-glucose (cytosol), Homo sapiens"
xref: Reactome:REACT_21316 "alpha-D-glucose (cytosol) <=> alpha-D-glucose (extracellular), Homo sapiens"
xref: Reactome:REACT_21415 "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2, Homo sapiens"
xref: Reactome:REACT_33843 "alpha-D-glucose (extracellular) <=> alpha-D-glucose (cytosol), Xenopus tropicalis"
xref: Reactome:REACT_77364 "alpha-D-glucose (extracellular) <=> alpha-D-glucose (cytosol), Canis familiaris"
xref: Reactome:REACT_78046 "alpha-D-glucose (extracellular) <=> alpha-D-glucose (cytosol), Mus musculus"
xref: Reactome:REACT_83667 "alpha-D-glucose (extracellular) <=> alpha-D-glucose (cytosol), Danio rerio"
xref: Reactome:REACT_83773 "alpha-D-glucose (extracellular) <=> alpha-D-glucose (cytosol), Sus scrofa"
xref: Reactome:REACT_84371 "alpha-D-glucose (extracellular) <=> alpha-D-glucose (cytosol), Bos taurus"
xref: Reactome:REACT_84665 "alpha-D-glucose (extracellular) <=> alpha-D-glucose (cytosol), Gallus gallus"
xref: Reactome:REACT_85135 "alpha-D-glucose (extracellular) <=> alpha-D-glucose (cytosol), Taeniopygia guttata"
xref: Reactome:REACT_98457 "alpha-D-glucose (extracellular) <=> alpha-D-glucose (cytosol), Rattus norvegicus"
is_a: GO:0015149 ! hexose transmembrane transporter activity
relationship: part_of GO:1904659 ! glucose transmembrane transport

[Term]
id: GO:0005356
name: hydrogen:glucose symporter activity
namespace: molecular_function
alt_id: GO:0005361
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport]
synonym: "hydrogen:glucose transporter activity" RELATED []
synonym: "transepithelial hydrogen/glucose transporter activity" RELATED []
synonym: "transepithelial hydrogen:glucose symporter activity" NARROW []
synonym: "transepithelial hydrogen:glucose transporter activity" RELATED []
is_a: GO:0005355 ! glucose transmembrane transporter activity
is_a: GO:0009679 ! hexose:proton symporter activity

[Term]
id: GO:0005357
name: constitutive hydrogen:glucose symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. This activity is constitutive and therefore always present, regardless of demand. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport]
synonym: "constitutive hydrogen/glucose transporter activity" BROAD []
synonym: "constitutive hydrogen:glucose transporter activity" BROAD []
is_a: GO:0005356 ! hydrogen:glucose symporter activity

[Term]
id: GO:0005358
name: high-affinity hydrogen:glucose symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. This activity is constitutive and therefore always present, regardless of demand. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport]
synonym: "high-affinity hydrogen/glucose transporter activity" BROAD []
synonym: "high-affinity hydrogen:glucose transporter activity" BROAD []
is_a: GO:0005356 ! hydrogen:glucose symporter activity

[Term]
id: GO:0005359
name: low-affinity hydrogen:glucose symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport]
synonym: "low-affinity hydrogen/glucose transporter activity" BROAD []
synonym: "low-affinity hydrogen:glucose transporter activity" BROAD []
is_a: GO:0005356 ! hydrogen:glucose symporter activity

[Term]
id: GO:0005360
name: insulin-responsive hydrogen:glucose symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+, in response to a stimulus by insulin. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport]
synonym: "insulin-responsive hydrogen:glucose transporter activity" RELATED []
synonym: "transepithelial hydrogen/glucose transporter activity" RELATED []
is_a: GO:0005356 ! hydrogen:glucose symporter activity

[Term]
id: GO:0005362
name: low-affinity glucose:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + Na+(out) = glucose(in) + Na+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [TC:2.A.21.3.-]
synonym: "low-affinity glucose-sodium cotransporter activity" BROAD []
xref: Reactome:REACT_101015 "Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4, Sus scrofa"
xref: Reactome:REACT_101698 "Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4, Rattus norvegicus"
xref: Reactome:REACT_109806 "Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4, Escherichia coli"
xref: Reactome:REACT_19292 "Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4, Homo sapiens"
xref: Reactome:REACT_34643 "Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4, Bos taurus"
xref: Reactome:REACT_80563 "Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4, Xenopus tropicalis"
xref: Reactome:REACT_91563 "Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4, Danio rerio"
xref: Reactome:REACT_92119 "Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4, Gallus gallus"
xref: Reactome:REACT_98263 "Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4, Canis familiaris"
xref: Reactome:REACT_98300 "Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4, Mus musculus"
is_a: GO:0005412 ! glucose:sodium symporter activity

[Term]
id: GO:0005363
name: maltose transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015581
def: "Enables the transfer of maltose from one side of the membrane to the other. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the enzymatic breakdown of glycogen and starch." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
subset: gosubset_prok
synonym: "maltose porter activity" EXACT []
xref: RHEA:33174
is_a: GO:0015154 ! disaccharide transmembrane transporter activity
relationship: part_of GO:0015768 ! maltose transport

[Term]
id: GO:0005364
name: maltose:proton symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: maltose(out) + H+(out) = maltose(in) + H+(in)." [TC:2.A.1.1.10]
synonym: "hydrogen/maltose transporter activity" BROAD []
synonym: "maltose permease" BROAD []
synonym: "maltose:hydrogen symporter activity" EXACT []
is_a: GO:0005351 ! sugar:proton symporter activity
is_a: GO:0005363 ! maltose transmembrane transporter activity

[Term]
id: GO:0005365
name: myo-inositol transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of myo-inositol from one side of the membrane to the other. Myo-inositol is 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms." [GOC:ai]
subset: gosubset_prok
synonym: "vitamin Bh transporter activity" EXACT []
is_a: GO:0015166 ! polyol transmembrane transporter activity
relationship: part_of GO:0015798 ! myo-inositol transport

[Term]
id: GO:0005366
name: myo-inositol:proton symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: myo-inositol(out) + H+(out) = myo-inositol(in) + H+(in)." [TC:2.A.1.1.8]
synonym: "hydrogen/myo-inositol transporter activity" BROAD []
synonym: "myo-inositol:hydrogen symporter activity" EXACT []
xref: Reactome:REACT_102984 "HMIT co-transports myo-inositol with a proton, Bos taurus"
xref: Reactome:REACT_109351 "HMIT co-transports myo-inositol with a proton, Taeniopygia guttata"
xref: Reactome:REACT_109515 "HMIT co-transports myo-inositol with a proton, Canis familiaris"
xref: Reactome:REACT_109660 "HMIT co-transports myo-inositol with a proton, Caenorhabditis elegans"
xref: Reactome:REACT_110606 "HMIT co-transports myo-inositol with a proton, Saccharomyces cerevisiae"
xref: Reactome:REACT_113525 "HMIT co-transports myo-inositol with a proton, Dictyostelium discoideum"
xref: Reactome:REACT_114462 "HMIT co-transports myo-inositol with a proton, Gallus gallus"
xref: Reactome:REACT_19215 "HMIT co-transports myo-inositol with a proton, Homo sapiens"
xref: Reactome:REACT_33092 "HMIT co-transports myo-inositol with a proton, Arabidopsis thaliana"
xref: Reactome:REACT_33736 "HMIT co-transports myo-inositol with a proton, Xenopus tropicalis"
xref: Reactome:REACT_82468 "HMIT co-transports myo-inositol with a proton, Danio rerio"
xref: Reactome:REACT_84498 "HMIT co-transports myo-inositol with a proton, Sus scrofa"
xref: Reactome:REACT_90383 "HMIT co-transports myo-inositol with a proton, Oryza sativa"
xref: Reactome:REACT_90727 "HMIT co-transports myo-inositol with a proton, Schizosaccharomyces pombe"
xref: Reactome:REACT_92182 "HMIT co-transports myo-inositol with a proton, Mus musculus"
xref: Reactome:REACT_94222 "HMIT co-transports myo-inositol with a proton, Rattus norvegicus"
xref: Reactome:REACT_95477 "HMIT co-transports myo-inositol with a proton, Escherichia coli"
is_a: GO:0005365 ! myo-inositol transmembrane transporter activity
is_a: GO:0015295 ! solute:proton symporter activity

[Term]
id: GO:0005367
name: myo-inositol:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: myo-inositol(out) + Na+(out) = myo-inositol(in) + Na+(in)." [TC:2.A.21.4.-]
synonym: "myo-inositol-sodium cotransporter activity" BROAD []
xref: Reactome:REACT_104737 "Co-transport (influx) of myo-inositol and two Na+ ions by SMIT, Taeniopygia guttata"
xref: Reactome:REACT_109231 "Co-transport (influx) of myo-inositol and two Na+ ions by SMIT, Mus musculus"
xref: Reactome:REACT_19415 "Co-transport (influx) of myo-inositol and two Na+ ions by SMIT, Homo sapiens"
xref: Reactome:REACT_28856 "Co-transport (influx) of myo-inositol and two Na+ ions by SMIT, Gallus gallus"
xref: Reactome:REACT_29916 "Co-transport (influx) of myo-inositol and two Na+ ions by SMIT, Danio rerio"
xref: Reactome:REACT_34640 "Co-transport (influx) of myo-inositol and two Na+ ions by SMIT, Escherichia coli"
xref: Reactome:REACT_80270 "Co-transport (influx) of myo-inositol and two Na+ ions by SMIT, Sus scrofa"
xref: Reactome:REACT_85439 "Co-transport (influx) of myo-inositol and two Na+ ions by SMIT, Canis familiaris"
xref: Reactome:REACT_93913 "Co-transport (influx) of myo-inositol and two Na+ ions by SMIT, Rattus norvegicus"
is_a: GO:0005365 ! myo-inositol transmembrane transporter activity
is_a: GO:0015370 ! solute:sodium symporter activity

[Term]
id: GO:0005368
name: taurine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of taurine from one side of the membrane to the other. Taurine (2-aminoethanesulfonic acid) is a sulphur-containing amino acid derivative which is important in the metabolism of fats." [GOC:ai]
subset: gosubset_prok
xref: RHEA:14616
is_a: GO:1901682 ! sulfur compound transmembrane transporter activity

[Term]
id: GO:0005369
name: taurine:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: taurine(out) + Na+(out) = taurine(in) + Na+(in)." [TC:2.A.22.3.3]
synonym: "sodium/chloride-dependent taurine transporter" BROAD []
is_a: GO:0005343 ! organic acid:sodium symporter activity
is_a: GO:0005368 ! taurine transmembrane transporter activity

[Term]
id: GO:0005371
name: tricarboxylate secondary active transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0005370
def: "Catalysis of the transfer of tricarboxylate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "tricarboxylate carrier activity" EXACT []
is_a: GO:0015142 ! tricarboxylic acid transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0005372
name: water transmembrane transporter activity
namespace: molecular_function
def: "Enables the directed movement of water (H2O) from one side of a membrane to the other." [GOC:ai]
subset: gosubset_prok
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity
relationship: part_of GO:0006833 ! water transport

[Term]
id: GO:0005373
name: obsolete heavy metal ion porter activity
namespace: molecular_function
def: "OBSOLETE. A transporter of heavy metal ions that utilizes a carrier-mediated process to catalyze uniport, symport or antiport between aqueous phases on either side of a lipid membrane." [GOC:ai]
comment: This term was made obsolete because it represents a gene product and not a molecular function.
synonym: "heavy metal ion porter activity" EXACT []
synonym: "metal ion transporter" BROAD []
is_obsolete: true
consider: GO:0015291
consider: GO:0046873

[Term]
id: GO:0005375
name: copper ion transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0005378
alt_id: GO:0005379
alt_id: GO:0005380
def: "Catalysis of the transfer of copper (Cu) ions from one side of a membrane to the other." [GOC:ai]
subset: gosubset_prok
synonym: "intracellular copper ion transporter" NARROW []
synonym: "plasma membrane copper transporter" NARROW []
xref: Reactome:REACT_105930 "Cellular copper transport is mediated by human copper transporter 1 hCTR1, Danio rerio"
xref: Reactome:REACT_107993 "Cellular copper transport is mediated by human copper transporter 1 hCTR1, Mus musculus"
xref: Reactome:REACT_20667 "Cellular copper transport is mediated by human copper transporter 1 hCTR1, Homo sapiens"
xref: Reactome:REACT_28831 "Cellular copper transport is mediated by human copper transporter 1 hCTR1, Xenopus tropicalis"
xref: Reactome:REACT_77095 "Cellular copper transport is mediated by human copper transporter 1 hCTR1, Taeniopygia guttata"
xref: Reactome:REACT_77964 "Cellular copper transport is mediated by human copper transporter 1 hCTR1, Rattus norvegicus"
xref: Reactome:REACT_82127 "Cellular copper transport is mediated by human copper transporter 1 hCTR1, Dictyostelium discoideum"
xref: Reactome:REACT_85120 "Cellular copper transport is mediated by human copper transporter 1 hCTR1, Gallus gallus"
xref: Reactome:REACT_85138 "Cellular copper transport is mediated by human copper transporter 1 hCTR1, Canis familiaris"
xref: Reactome:REACT_95227 "Cellular copper transport is mediated by human copper transporter 1 hCTR1, Bos taurus"
xref: RHEA:28706
is_a: GO:0046915 ! transition metal ion transmembrane transporter activity
relationship: part_of GO:0035434 ! copper ion transmembrane transport

[Term]
id: GO:0005376
name: obsolete plasma membrane copper transporter
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it contains both component and function information.
synonym: "plasma membrane copper transporter" EXACT []
is_obsolete: true
consider: GO:0005375
consider: GO:0005886

[Term]
id: GO:0005377
name: obsolete intracellular copper ion transporter
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it contains both component and function information.
synonym: "intracellular copper ion transporter" EXACT []
synonym: "intracellular copper transporter" EXACT []
is_obsolete: true
consider: GO:0005375
consider: GO:0005622

[Term]
id: GO:0005381
name: iron ion transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0005382
alt_id: GO:0016033
def: "Catalysis of the transfer of iron (Fe) ions from one side of a membrane to the other." [GOC:ai]
subset: gosubset_prok
synonym: "iron transporter activity" EXACT []
synonym: "multicopper ferroxidase iron transport mediator activity" RELATED []
synonym: "transmembrane iron ion permease activity" EXACT []
synonym: "transmembrane iron permease activity" EXACT []
synonym: "zinc, iron permease activity" RELATED []
xref: Reactome:REACT_106097 "DCT1 (NRAMP2) mediates divalent iron uptake across the apical membrane of enterocytes, Caenorhabditis elegans"
xref: Reactome:REACT_107404 "DCT1 (NRAMP2) mediates divalent iron uptake across the apical membrane of enterocytes, Xenopus tropicalis"
xref: Reactome:REACT_113775 "DCT1 (NRAMP2) mediates divalent iron uptake across the apical membrane of enterocytes, Staphylococcus aureus N315"
xref: Reactome:REACT_20526 "DCT1 (NRAMP2) mediates divalent iron uptake across the apical membrane of enterocytes, Homo sapiens"
xref: Reactome:REACT_20531 "Ferroportin mediates iron influx across the basolateral membrane of enterocytes, Homo sapiens"
xref: Reactome:REACT_23996 "Ferroportin mediates iron efflux on macrophages, Homo sapiens"
xref: Reactome:REACT_25069 "Iron diffuses out of the endosome, Homo sapiens"
xref: Reactome:REACT_31663 "DCT1 (NRAMP2) mediates divalent iron uptake across the apical membrane of enterocytes, Danio rerio"
xref: Reactome:REACT_80754 "DCT1 (NRAMP2) mediates divalent iron uptake across the apical membrane of enterocytes, Canis familiaris"
xref: Reactome:REACT_83241 "DCT1 (NRAMP2) mediates divalent iron uptake across the apical membrane of enterocytes, Oryza sativa"
xref: Reactome:REACT_86040 "DCT1 (NRAMP2) mediates divalent iron uptake across the apical membrane of enterocytes, Plasmodium falciparum"
xref: Reactome:REACT_87524 "DCT1 (NRAMP2) mediates divalent iron uptake across the apical membrane of enterocytes, Drosophila melanogaster"
xref: Reactome:REACT_88121 "DCT1 (NRAMP2) mediates divalent iron uptake across the apical membrane of enterocytes, Dictyostelium discoideum"
xref: Reactome:REACT_89525 "DCT1 (NRAMP2) mediates divalent iron uptake across the apical membrane of enterocytes, Rattus norvegicus"
xref: Reactome:REACT_94194 "DCT1 (NRAMP2) mediates divalent iron uptake across the apical membrane of enterocytes, Mus musculus"
xref: Reactome:REACT_97889 "DCT1 (NRAMP2) mediates divalent iron uptake across the apical membrane of enterocytes, Arabidopsis thaliana"
xref: Reactome:REACT_98239 "DCT1 (NRAMP2) mediates divalent iron uptake across the apical membrane of enterocytes, Bos taurus"
is_a: GO:0046915 ! transition metal ion transmembrane transporter activity
relationship: part_of GO:0034755 ! iron ion transmembrane transport

[Term]
id: GO:0005384
name: manganese ion transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of manganese (Mn) ions from one side of a membrane to the other." [GOC:dgf]
subset: gosubset_prok
is_a: GO:0046915 ! transition metal ion transmembrane transporter activity
relationship: part_of GO:0071421 ! manganese ion transmembrane transport

[Term]
id: GO:0005385
name: zinc ion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of zinc (Zn) ions from one side of a membrane to the other." [GOC:dgf]
subset: gosubset_prok
synonym: "cobalt, zinc uptake permease activity" RELATED []
synonym: "zinc, cadmium uptake permease activity" RELATED []
synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" RELATED []
synonym: "zinc, iron permease activity" NARROW []
xref: Reactome:REACT_100060 "ZnT2 facilitates zinc vesicular sequestration, Caenorhabditis elegans"
xref: Reactome:REACT_100128 "ZnT2 facilitates zinc vesicular sequestration, Arabidopsis thaliana"
xref: Reactome:REACT_100475 "ZnT8 transports zinc into the secretory vesicles of pancreatic beta cells specifically, Dictyostelium discoideum"
xref: Reactome:REACT_100814 "ZnT3 transports zinc into synaptic vesicles, Escherichia coli"
xref: Reactome:REACT_101619 "ZnT1 mediates the efflux of zinc from the cell, Danio rerio"
xref: Reactome:REACT_102944 "ZnT3 transports zinc into synaptic vesicles, Taeniopygia guttata"
xref: Reactome:REACT_103555 "ZnT8 transports zinc into the secretory vesicles of pancreatic beta cells specifically, Rattus norvegicus"
xref: Reactome:REACT_103999 "ZnT5 transports zinc into secretory granules in pancreatic beta cells, Danio rerio"
xref: Reactome:REACT_104320 "ZnT3 transports zinc into synaptic vesicles, Canis familiaris"
xref: Reactome:REACT_104747 "ZnT5 transports zinc into secretory granules in pancreatic beta cells, Xenopus tropicalis"
xref: Reactome:REACT_105375 "ZnT3 transports zinc into synaptic vesicles, Xenopus tropicalis"
xref: Reactome:REACT_106184 "ZnT3 transports zinc into synaptic vesicles, Danio rerio"
xref: Reactome:REACT_107793 "ZnT6 transports zinc into the golgi apparatus, Mus musculus"
xref: Reactome:REACT_107978 "ZnT3 transports zinc into synaptic vesicles, Arabidopsis thaliana"
xref: Reactome:REACT_108684 "ZnT3 transports zinc into synaptic vesicles, Plasmodium falciparum"
xref: Reactome:REACT_109118 "ZnT6 transports zinc into the golgi apparatus, Canis familiaris"
xref: Reactome:REACT_109163 "ZnT1 mediates the efflux of zinc from the cell, Taeniopygia guttata"
xref: Reactome:REACT_110174 "ZnT5 transports zinc into secretory granules in pancreatic beta cells, Mus musculus"
xref: Reactome:REACT_110828 "ZnT8 transports zinc into the secretory vesicles of pancreatic beta cells specifically, Arabidopsis thaliana"
xref: Reactome:REACT_110830 "ZnT2 facilitates zinc vesicular sequestration, Plasmodium falciparum"
xref: Reactome:REACT_113068 "ZnT5 transports zinc into secretory granules in pancreatic beta cells, Arabidopsis thaliana"
xref: Reactome:REACT_113230 "ZnT7 transports zinc into the golgi apparatus, Arabidopsis thaliana"
xref: Reactome:REACT_113286 "ZnT7 transports zinc into the golgi apparatus, Oryza sativa"
xref: Reactome:REACT_115265 "ZnT5 transports zinc into secretory granules in pancreatic beta cells, Oryza sativa"
xref: Reactome:REACT_15499 "Formation of Proinsulin-Zinc-Calcium Complex, Homo sapiens"
xref: Reactome:REACT_20502 "ZnT3 transports zinc into synaptic vesicles, Homo sapiens"
xref: Reactome:REACT_20512 "ZnT7 transports zinc into the golgi apparatus, Homo sapiens"
xref: Reactome:REACT_20516 "ZIP8 mediates zinc influx into cells, Homo sapiens"
xref: Reactome:REACT_20535 "Znt7 transports zinc into the golgi apparatus, Mus musculus"
xref: Reactome:REACT_20536 "hZIP10 mediates zinc influx into cells, Homo sapiens"
xref: Reactome:REACT_20544 "Znt3 transports zinc into synaptic vesicles, Mus musculus"
xref: Reactome:REACT_20545 "ZnT5 transports zinc into secretory granules in pancreatic beta cells, Homo sapiens"
xref: Reactome:REACT_20575 "ZIP7 mediates zinc efflux from the endoplasmic reticulum, Homo sapiens"
xref: Reactome:REACT_20607 "ZnT6 transports zinc into the golgi apparatus, Homo sapiens"
xref: Reactome:REACT_20614 "ZnT1 mediates the efflux of zinc from the cell, Homo sapiens"
xref: Reactome:REACT_20621 "mZIP5 mediates zinc uptake by cells, Mus musculus"
xref: Reactome:REACT_20622 "Znt2 facilitates zinc vesicular sequestration, Rattus norvegicus"
xref: Reactome:REACT_20628 "rZip10 mediates zinc influx into cells, Rattus norvegicus"
xref: Reactome:REACT_20641 "hZIP5 mediates zinc uptake by cells, Homo sapiens"
xref: Reactome:REACT_20648 "ZIP6 and ZIP14 mediate zinc influx into cells, Homo sapiens"
xref: Reactome:REACT_20673 "hZIP1-4 mediate zinc uptake by cells, Homo sapiens"
xref: Reactome:REACT_20674 "ZnT2 facilitates zinc vesicular sequestration, Homo sapiens"
xref: Reactome:REACT_20678 "ZnT8 transports zinc into the secretory vesicles of pancreatic beta cells specifically, Homo sapiens"
xref: Reactome:REACT_28580 "ZnT8 transports zinc into the secretory vesicles of pancreatic beta cells specifically, Drosophila melanogaster"
xref: Reactome:REACT_28956 "ZnT2 facilitates zinc vesicular sequestration, Staphylococcus aureus N315"
xref: Reactome:REACT_29130 "ZnT8 transports zinc into the secretory vesicles of pancreatic beta cells specifically, Mus musculus"
xref: Reactome:REACT_29501 "ZnT7 transports zinc into the golgi apparatus, Canis familiaris"
xref: Reactome:REACT_30238 "ZnT8 transports zinc into the secretory vesicles of pancreatic beta cells specifically, Danio rerio"
xref: Reactome:REACT_31087 "ZnT6 transports zinc into the golgi apparatus, Gallus gallus"
xref: Reactome:REACT_31110 "ZnT8 transports zinc into the secretory vesicles of pancreatic beta cells specifically, Oryza sativa"
xref: Reactome:REACT_31271 "ZnT2 facilitates zinc vesicular sequestration, Mus musculus"
xref: Reactome:REACT_31543 "ZnT8 transports zinc into the secretory vesicles of pancreatic beta cells specifically, Taeniopygia guttata"
xref: Reactome:REACT_31568 "ZnT8 transports zinc into the secretory vesicles of pancreatic beta cells specifically, Gallus gallus"
xref: Reactome:REACT_32226 "ZnT1 mediates the efflux of zinc from the cell, Mus musculus"
xref: Reactome:REACT_32805 "ZnT7 transports zinc into the golgi apparatus, Rattus norvegicus"
xref: Reactome:REACT_34034 "ZnT3 transports zinc into synaptic vesicles, Drosophila melanogaster"
xref: Reactome:REACT_34087 "ZnT5 transports zinc into secretory granules in pancreatic beta cells, Rattus norvegicus"
xref: Reactome:REACT_34194 "ZnT7 transports zinc into the golgi apparatus, Dictyostelium discoideum"
xref: Reactome:REACT_34314 "ZnT6 transports zinc into the golgi apparatus, Taeniopygia guttata"
xref: Reactome:REACT_34361 "ZnT7 transports zinc into the golgi apparatus, Taeniopygia guttata"
xref: Reactome:REACT_34790 "ZnT2 facilitates zinc vesicular sequestration, Bos taurus"
xref: Reactome:REACT_77641 "Formation of Proinsulin-Zinc-Calcium Complex, Canis familiaris"
xref: Reactome:REACT_77688 "ZnT8 transports zinc into the secretory vesicles of pancreatic beta cells specifically, Xenopus tropicalis"
xref: Reactome:REACT_78251 "ZnT2 facilitates zinc vesicular sequestration, Escherichia coli"
xref: Reactome:REACT_78732 "ZnT8 transports zinc into the secretory vesicles of pancreatic beta cells specifically, Caenorhabditis elegans"
xref: Reactome:REACT_78801 "ZnT2 facilitates zinc vesicular sequestration, Canis familiaris"
xref: Reactome:REACT_79074 "ZnT7 transports zinc into the golgi apparatus, Danio rerio"
xref: Reactome:REACT_79384 "ZnT6 transports zinc into the golgi apparatus, Danio rerio"
xref: Reactome:REACT_79443 "ZnT7 transports zinc into the golgi apparatus, Bos taurus"
xref: Reactome:REACT_79563 "ZnT2 facilitates zinc vesicular sequestration, Oryza sativa"
xref: Reactome:REACT_79648 "ZnT6 transports zinc into the golgi apparatus, Caenorhabditis elegans"
xref: Reactome:REACT_79684 "Formation of Proinsulin-Zinc-Calcium Complex, Gallus gallus"
xref: Reactome:REACT_80034 "ZnT7 transports zinc into the golgi apparatus, Gallus gallus"
xref: Reactome:REACT_80143 "ZnT7 transports zinc into the golgi apparatus, Drosophila melanogaster"
xref: Reactome:REACT_80930 "ZnT6 transports zinc into the golgi apparatus, Bos taurus"
xref: Reactome:REACT_82550 "ZnT1 mediates the efflux of zinc from the cell, Rattus norvegicus"
xref: Reactome:REACT_82559 "ZnT1 mediates the efflux of zinc from the cell, Xenopus tropicalis"
xref: Reactome:REACT_83166 "ZnT6 transports zinc into the golgi apparatus, Rattus norvegicus"
xref: Reactome:REACT_84057 "ZnT5 transports zinc into secretory granules in pancreatic beta cells, Gallus gallus"
xref: Reactome:REACT_84376 "Formation of Proinsulin-Zinc-Calcium Complex, Taeniopygia guttata"
xref: Reactome:REACT_84515 "ZnT6 transports zinc into the golgi apparatus, Xenopus tropicalis"
xref: Reactome:REACT_84672 "ZnT8 transports zinc into the secretory vesicles of pancreatic beta cells specifically, Sus scrofa"
xref: Reactome:REACT_85242 "ZnT2 facilitates zinc vesicular sequestration, Dictyostelium discoideum"
xref: Reactome:REACT_85968 "ZnT1 mediates the efflux of zinc from the cell, Schizosaccharomyces pombe"
xref: Reactome:REACT_86417 "ZnT1 mediates the efflux of zinc from the cell, Saccharomyces cerevisiae"
xref: Reactome:REACT_87480 "ZnT5 transports zinc into secretory granules in pancreatic beta cells, Taeniopygia guttata"
xref: Reactome:REACT_87820 "ZnT3 transports zinc into synaptic vesicles, Staphylococcus aureus N315"
xref: Reactome:REACT_87889 "ZnT5 transports zinc into secretory granules in pancreatic beta cells, Saccharomyces cerevisiae"
xref: Reactome:REACT_88029 "ZnT8 transports zinc into the secretory vesicles of pancreatic beta cells specifically, Plasmodium falciparum"
xref: Reactome:REACT_88379 "ZnT1 mediates the efflux of zinc from the cell, Dictyostelium discoideum"
xref: Reactome:REACT_89344 "ZnT7 transports zinc into the golgi apparatus, Sus scrofa"
xref: Reactome:REACT_89552 "Formation of Proinsulin-Zinc-Calcium Complex, Mus musculus"
xref: Reactome:REACT_89921 "ZnT2 facilitates zinc vesicular sequestration, Gallus gallus"
xref: Reactome:REACT_90004 "Formation of Proinsulin-Zinc-Calcium Complex, Danio rerio"
xref: Reactome:REACT_90282 "ZnT8 transports zinc into the secretory vesicles of pancreatic beta cells specifically, Staphylococcus aureus N315"
xref: Reactome:REACT_90711 "ZnT8 transports zinc into the secretory vesicles of pancreatic beta cells specifically, Escherichia coli"
xref: Reactome:REACT_90713 "Formation of Proinsulin-Zinc-Calcium Complex, Rattus norvegicus"
xref: Reactome:REACT_90907 "ZnT1 mediates the efflux of zinc from the cell, Bos taurus"
xref: Reactome:REACT_91034 "ZnT7 transports zinc into the golgi apparatus, Xenopus tropicalis"
xref: Reactome:REACT_91236 "ZnT8 transports zinc into the secretory vesicles of pancreatic beta cells specifically, Canis familiaris"
xref: Reactome:REACT_92180 "ZnT5 transports zinc into secretory granules in pancreatic beta cells, Canis familiaris"
xref: Reactome:REACT_92330 "ZnT2 facilitates zinc vesicular sequestration, Drosophila melanogaster"
xref: Reactome:REACT_93110 "ZnT5 transports zinc into secretory granules in pancreatic beta cells, Bos taurus"
xref: Reactome:REACT_93189 "ZnT3 transports zinc into synaptic vesicles, Oryza sativa"
xref: Reactome:REACT_93725 "ZnT3 transports zinc into synaptic vesicles, Bos taurus"
xref: Reactome:REACT_93889 "ZnT3 transports zinc into synaptic vesicles, Dictyostelium discoideum"
xref: Reactome:REACT_94328 "ZnT2 facilitates zinc vesicular sequestration, Xenopus tropicalis"
xref: Reactome:REACT_94483 "Formation of Proinsulin-Zinc-Calcium Complex, Xenopus tropicalis"
xref: Reactome:REACT_94791 "ZnT1 mediates the efflux of zinc from the cell, Drosophila melanogaster"
xref: Reactome:REACT_95274 "ZnT6 transports zinc into the golgi apparatus, Sus scrofa"
xref: Reactome:REACT_95344 "ZnT5 transports zinc into secretory granules in pancreatic beta cells, Caenorhabditis elegans"
xref: Reactome:REACT_95882 "ZnT5 transports zinc into secretory granules in pancreatic beta cells, Schizosaccharomyces pombe"
xref: Reactome:REACT_97340 "Formation of Proinsulin-Zinc-Calcium Complex, Bos taurus"
xref: Reactome:REACT_97796 "ZnT3 transports zinc into synaptic vesicles, Rattus norvegicus"
xref: Reactome:REACT_98988 "ZnT3 transports zinc into synaptic vesicles, Caenorhabditis elegans"
xref: Reactome:REACT_99089 "ZnT1 mediates the efflux of zinc from the cell, Canis familiaris"
xref: Reactome:REACT_99464 "ZnT1 mediates the efflux of zinc from the cell, Gallus gallus"
xref: Reactome:REACT_99797 "ZnT2 facilitates zinc vesicular sequestration, Taeniopygia guttata"
xref: RHEA:29354
is_a: GO:0046915 ! transition metal ion transmembrane transporter activity
is_a: GO:0072509 ! divalent inorganic cation transmembrane transporter activity
relationship: part_of GO:0071577 ! zinc II ion transmembrane transport

[Term]
id: GO:0005388
name: calcium-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans)." [EC:3.6.3.8]
subset: gosubset_prok
synonym: "ATP phosphohydrolase (Ca2+-transporting)" EXACT [EC:3.6.3.8]
synonym: "Ca(2+)-transporting ATPase activity" EXACT [EC:3.6.3.8]
synonym: "Ca2+-pumping ATPase activity" EXACT [EC:3.6.3.8]
synonym: "Ca2+-transporting ATPase activity" EXACT [EC:3.6.3.8]
synonym: "calcium ABC transporter" NARROW []
synonym: "calcium efflux ATPase" NARROW []
synonym: "calcium pump" BROAD []
synonym: "calcium transporting ATPase activity" EXACT []
synonym: "calcium-translocating P-type ATPase activity" NARROW [EC:3.6.3.8]
synonym: "plasma membrane Ca-ATPase" NARROW [EC:3.6.3.8]
synonym: "sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW [EC:3.6.3.8]
synonym: "sarcoplasmic reticulum ATPase" NARROW []
xref: EC:3.6.3.8
xref: MetaCyc:3.6.3.8-RXN
xref: Reactome:REACT_100629 "Sequestration of Ca2+ to dense tubular network lumen, Oryza sativa"
xref: Reactome:REACT_102741 "Sequestration of Ca2+ to intracellular stores, Mus musculus"
xref: Reactome:REACT_103475 "Sequestration of Ca2+ to intracellular stores, Taeniopygia guttata"
xref: Reactome:REACT_103504 "PMCA extrusion of Ca2+, Sus scrofa"
xref: Reactome:REACT_104608 "Sequestration of Ca2+ to dense tubular network lumen, Taeniopygia guttata"
xref: Reactome:REACT_105289 "Sequestration of Ca2+ to intracellular stores, Caenorhabditis elegans"
xref: Reactome:REACT_105648 "PMCA extrusion of Ca2+, Drosophila melanogaster"
xref: Reactome:REACT_107403 "Sequestration of Ca2+ to dense tubular network lumen, Caenorhabditis elegans"
xref: Reactome:REACT_108678 "PMCA extrusion of Ca2+, Canis familiaris"
xref: Reactome:REACT_109986 "PMCA extrusion of Ca2+, Xenopus tropicalis"
xref: Reactome:REACT_110168 "Sequestration of Ca2+ to intracellular stores, Danio rerio"
xref: Reactome:REACT_110336 "Sequestration of Ca2+ to dense tubular network lumen, Canis familiaris"
xref: Reactome:REACT_23784 "Sequestration of Ca2+ to dense tubular network lumen, Homo sapiens"
xref: Reactome:REACT_23956 "PMCA extrusion of Ca2+, Homo sapiens"
xref: Reactome:REACT_25301 "Calcium is sequestered to the golgi by secretory pathway calcium-ATPases (SPCAs), Homo sapiens"
xref: Reactome:REACT_25316 "Sequestration of Ca2+ to intracellular stores, Homo sapiens"
xref: Reactome:REACT_30159 "PMCA extrusion of Ca2+, Mycobacterium tuberculosis"
xref: Reactome:REACT_30263 "Sequestration of Ca2+ to intracellular stores, Sus scrofa"
xref: Reactome:REACT_30283 "Sequestration of Ca2+ to intracellular stores, Plasmodium falciparum"
xref: Reactome:REACT_32376 "Sequestration of Ca2+ to dense tubular network lumen, Bos taurus"
xref: Reactome:REACT_32994 "PMCA extrusion of Ca2+, Gallus gallus"
xref: Reactome:REACT_33291 "Sequestration of Ca2+ to intracellular stores, Gallus gallus"
xref: Reactome:REACT_70391 "PMCA extrusion of Ca2+, Caenorhabditis elegans"
xref: Reactome:REACT_77451 "Sequestration of Ca2+ to dense tubular network lumen, Arabidopsis thaliana"
xref: Reactome:REACT_79956 "PMCA extrusion of Ca2+, Danio rerio"
xref: Reactome:REACT_80425 "Sequestration of Ca2+ to dense tubular network lumen, Drosophila melanogaster"
xref: Reactome:REACT_80731 "Sequestration of Ca2+ to intracellular stores, Xenopus tropicalis"
xref: Reactome:REACT_82240 "Sequestration of Ca2+ to intracellular stores, Oryza sativa"
xref: Reactome:REACT_87191 "Sequestration of Ca2+ to dense tubular network lumen, Xenopus tropicalis"
xref: Reactome:REACT_89730 "Sequestration of Ca2+ to dense tubular network lumen, Plasmodium falciparum"
xref: Reactome:REACT_90134 "Sequestration of Ca2+ to dense tubular network lumen, Mus musculus"
xref: Reactome:REACT_90992 "Sequestration of Ca2+ to dense tubular network lumen, Rattus norvegicus"
xref: Reactome:REACT_91434 "PMCA extrusion of Ca2+, Mus musculus"
xref: Reactome:REACT_92437 "Sequestration of Ca2+ to intracellular stores, Arabidopsis thaliana"
xref: Reactome:REACT_92865 "PMCA extrusion of Ca2+, Taeniopygia guttata"
xref: Reactome:REACT_93246 "Sequestration of Ca2+ to dense tubular network lumen, Gallus gallus"
xref: Reactome:REACT_93527 "PMCA extrusion of Ca2+, Bos taurus"
xref: Reactome:REACT_94661 "PMCA extrusion of Ca2+, Rattus norvegicus"
xref: Reactome:REACT_94907 "Sequestration of Ca2+ to intracellular stores, Rattus norvegicus"
xref: Reactome:REACT_95108 "Sequestration of Ca2+ to dense tubular network lumen, Sus scrofa"
xref: Reactome:REACT_95824 "Sequestration of Ca2+ to dense tubular network lumen, Danio rerio"
xref: Reactome:REACT_96909 "Sequestration of Ca2+ to intracellular stores, Bos taurus"
xref: Reactome:REACT_98505 "Sequestration of Ca2+ to intracellular stores, Drosophila melanogaster"
xref: Reactome:REACT_98863 "Sequestration of Ca2+ to intracellular stores, Canis familiaris"
xref: RHEA:18108
is_a: GO:0015085 ! calcium ion transmembrane transporter activity
is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
is_a: GO:0019829 ! cation-transporting ATPase activity

[Term]
id: GO:0005391
name: sodium:potassium-exchanging ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in)." [EC:3.6.3.9]
subset: gosubset_prok
synonym: "(Na+ + K+)-activated ATPase activity" EXACT [EC:3.6.3.9]
synonym: "(Na+ + K+)-ATPase activity" EXACT [EC:3.6.3.9]
synonym: "ATP phosphohydrolase (Na+/K+-exchanging)" EXACT [EC:3.6.3.9]
synonym: "Na(+)/K(+)-ATPase activity" EXACT [EC:3.6.3.9]
synonym: "Na(+)/K(+)-exchanging ATPase activity" EXACT [EC:3.6.3.9]
synonym: "Na+,K+ pump" RELATED [EC:3.6.3.9]
synonym: "Na+,K+-ATPase activity" EXACT [EC:3.6.3.9]
synonym: "Na+/K+-ATPase activity" EXACT [EC:3.6.3.9]
synonym: "Na+/K+-exchanging ATPase activity" EXACT [EC:3.6.3.9]
synonym: "Na,K-activated ATPase activity" EXACT [EC:3.6.3.9]
synonym: "Na,K-pump" RELATED [EC:3.6.3.9]
synonym: "sodium pump" BROAD []
synonym: "sodium/potassium-exchanging ATPase activity" EXACT []
synonym: "sodium/potassium-transporting ATPase activity" EXACT [EC:3.6.3.9]
synonym: "sodium:potassium exchanging ATPase activity" EXACT []
xref: EC:3.6.3.9
xref: MetaCyc:3.6.3.9-RXN
xref: Reactome:REACT_25287 "The Na+/K+-transporting ATPase trimer exchanges sodium for potassium, Homo sapiens"
xref: RHEA:18356
is_a: GO:0008556 ! potassium-transporting ATPase activity
is_a: GO:0015081 ! sodium ion transmembrane transporter activity
relationship: part_of GO:0010248 ! establishment or maintenance of transmembrane electrochemical gradient
relationship: part_of GO:0090662 ! ATP hydrolysis coupled transmembrane transport

[Term]
id: GO:0005395
name: eye pigment precursor transporter activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O + eye pigment precursor(in) = ADP + phosphate + eye pigment precursor(out)." [TC:3.A.1.204.1]
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances

[Term]
id: GO:0005396
name: obsolete transmembrane conductance regulator activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because its meaning was ambiguous, it was undefined and its position in the tree wrong.
synonym: "transmembrane conductance regulator activity" EXACT []
is_obsolete: true
consider: GO:0043267

[Term]
id: GO:0005400
name: obsolete peroxisomal membrane transporter
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it contains both component and function information.
synonym: "peroxisomal membrane transporter" EXACT []
is_obsolete: true
consider: GO:0005215
consider: GO:0005777

[Term]
id: GO:0005402
name: cation:sugar symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + cation(out) = sugar(in) + cation(in)." [GOC:ai]
subset: gosubset_prok
synonym: "cation/sugar symporter activity" EXACT []
synonym: "sugar:cation symporter activity" EXACT []
is_a: GO:0015294 ! solute:cation symporter activity
is_a: GO:0051119 ! sugar transmembrane transporter activity

[Term]
id: GO:0005412
name: glucose:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + Na+(out) = glucose(in) + Na+(in)." [TC:2.A.21.3.-]
synonym: "sodium/glucose symporter activity" EXACT []
xref: Reactome:REACT_100186 "Co-transport (influx) of glucose and Na+ ions by SGLT2, Escherichia coli"
xref: Reactome:REACT_100486 "Transport (influx) of glucose, galactose, and sodium ions by SGLT1, Rattus norvegicus"
xref: Reactome:REACT_103262 "Transport (influx) of glucose, galactose, and sodium ions by SGLT1, Gallus gallus"
xref: Reactome:REACT_104332 "Transport (influx) of glucose, galactose, and sodium ions by SGLT1, Taeniopygia guttata"
xref: Reactome:REACT_106655 "Co-transport (influx) of glucose and Na+ ions by SGLT2, Rattus norvegicus"
xref: Reactome:REACT_107519 "Co-transport (influx) of glucose and Na+ ions by SGLT2, Sus scrofa"
xref: Reactome:REACT_110825 "Transport (influx) of glucose, galactose, and sodium ions by SGLT1, Mus musculus"
xref: Reactome:REACT_114364 "Co-transport (influx) of glucose and Na+ ions by SGLT2, Xenopus tropicalis"
xref: Reactome:REACT_19399 "Co-transport (influx) of glucose and Na+ ions by SGLT2, Homo sapiens"
xref: Reactome:REACT_30043 "Co-transport (influx) of glucose and Na+ ions by SGLT2, Bos taurus"
xref: Reactome:REACT_32377 "Co-transport (influx) of glucose and Na+ ions by SGLT2, Mus musculus"
xref: Reactome:REACT_72148 "Transport (influx) of glucose, galactose, and sodium ions by SGLT1, Canis familiaris"
xref: Reactome:REACT_78335 "Co-transport (influx) of glucose and Na+ ions by SGLT2, Canis familiaris"
xref: Reactome:REACT_80751 "Transport (influx) of glucose, galactose, and sodium ions by SGLT1, Xenopus tropicalis"
xref: Reactome:REACT_81584 "Co-transport (influx) of glucose and Na+ ions by SGLT2, Danio rerio"
xref: Reactome:REACT_88964 "Transport (influx) of glucose, galactose, and sodium ions by SGLT1, Escherichia coli"
xref: Reactome:REACT_90351 "Transport (influx) of glucose, galactose, and sodium ions by SGLT1, Danio rerio"
xref: Reactome:REACT_9525 "Transport (influx) of glucose, galactose, and sodium ions by SGLT1, Homo sapiens"
xref: Reactome:REACT_96774 "Transport (influx) of glucose, galactose, and sodium ions by SGLT1, Bos taurus"
xref: Reactome:REACT_98568 "Transport (influx) of glucose, galactose, and sodium ions by SGLT1, Sus scrofa"
is_a: GO:0005355 ! glucose transmembrane transporter activity
is_a: GO:0015370 ! solute:sodium symporter activity

[Term]
id: GO:0005415
name: nucleoside:sodium symporter activity
namespace: molecular_function
alt_id: GO:0008522
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleoside(out) + Na+(out) = nucleoside(in) + Na+(in)." [GOC:ai]
subset: gosubset_prok
synonym: "nucleoside-sodium cotransporter activity" BROAD []
synonym: "sodium-dependent nucleoside transporter activity" BROAD []
xref: Reactome:REACT_100349 "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2, Danio rerio"
xref: Reactome:REACT_101471 "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3, Gallus gallus"
xref: Reactome:REACT_104562 "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3, Drosophila melanogaster"
xref: Reactome:REACT_104728 "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3, Mus musculus"
xref: Reactome:REACT_106061 "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2, Caenorhabditis elegans"
xref: Reactome:REACT_107802 "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2, Escherichia coli"
xref: Reactome:REACT_108414 "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2, Staphylococcus aureus N315"
xref: Reactome:REACT_108643 "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2, Sus scrofa"
xref: Reactome:REACT_108904 "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3, Escherichia coli"
xref: Reactome:REACT_108916 "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2, Xenopus tropicalis"
xref: Reactome:REACT_109093 "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1, Canis familiaris"
xref: Reactome:REACT_109236 "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1, Drosophila melanogaster"
xref: Reactome:REACT_1504 "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3, Homo sapiens"
xref: Reactome:REACT_2011 "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2, Homo sapiens"
xref: Reactome:REACT_28790 "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1, Danio rerio"
xref: Reactome:REACT_30584 "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1, Xenopus tropicalis"
xref: Reactome:REACT_31795 "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1, Rattus norvegicus"
xref: Reactome:REACT_32175 "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3, Staphylococcus aureus N315"
xref: Reactome:REACT_34292 "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3, Caenorhabditis elegans"
xref: Reactome:REACT_54144 "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3, Bos taurus"
xref: Reactome:REACT_71386 "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1, Caenorhabditis elegans"
xref: Reactome:REACT_714 "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1, Homo sapiens"
xref: Reactome:REACT_77817 "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2, Drosophila melanogaster"
xref: Reactome:REACT_80960 "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2, Taeniopygia guttata"
xref: Reactome:REACT_81452 "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2, Bos taurus"
xref: Reactome:REACT_84302 "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3, Xenopus tropicalis"
xref: Reactome:REACT_88194 "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3, Rattus norvegicus"
xref: Reactome:REACT_88739 "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3, Sus scrofa"
xref: Reactome:REACT_89814 "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1, Sus scrofa"
xref: Reactome:REACT_90419 "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1, Staphylococcus aureus N315"
xref: Reactome:REACT_92229 "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1, Bos taurus"
xref: Reactome:REACT_93017 "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1, Mus musculus"
xref: Reactome:REACT_93684 "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1, Gallus gallus"
xref: Reactome:REACT_93891 "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2, Mus musculus"
xref: Reactome:REACT_94172 "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3, Canis familiaris"
xref: Reactome:REACT_94614 "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1, Taeniopygia guttata"
xref: Reactome:REACT_95452 "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2, Gallus gallus"
xref: Reactome:REACT_97009 "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3, Taeniopygia guttata"
xref: Reactome:REACT_97261 "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2, Rattus norvegicus"
xref: Reactome:REACT_98336 "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1, Escherichia coli"
is_a: GO:0005337 ! nucleoside transmembrane transporter activity
is_a: GO:0015370 ! solute:sodium symporter activity

[Term]
id: GO:0005416
name: cation:amino acid symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + cation(out) = amino acid(in) + cation(in)." [GOC:ai]
subset: gosubset_prok
synonym: "cation/amino acid symporter activity" EXACT []
is_a: GO:0015171 ! amino acid transmembrane transporter activity
is_a: GO:0015294 ! solute:cation symporter activity

[Term]
id: GO:0005427
name: proton-dependent oligopeptide secondary active transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a oligopeptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by proton movement." [GOC:mtg_transport, OMIM:600544]
subset: gosubset_prok
synonym: "hydrogen/oligopeptide symporter" RELATED []
synonym: "proton-dependent oligopeptide transporter activity" EXACT []
is_a: GO:0015322 ! secondary active oligopeptide transmembrane transporter activity

[Term]
id: GO:0005429
name: chromaffin granule amine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of amines across chromaffin granule membranes." [GOC:mah]
is_a: GO:0005275 ! amine transmembrane transporter activity
relationship: part_of GO:0015841 ! chromaffin granule amine transport

[Term]
id: GO:0005430
name: synaptic vesicle amine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of amines across synaptic vesicle membranes." [GOC:ai]
is_a: GO:0005275 ! amine transmembrane transporter activity
relationship: part_of GO:0015842 ! aminergic neurotransmitter loading into synaptic vesicle

[Term]
id: GO:0005432
name: calcium:sodium antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in)." [GOC:curators, PMID:16371597]
subset: gosubset_prok
synonym: "mitochondrial sodium/calcium ion exchange" RELATED []
synonym: "sodium/calcium exchanger" EXACT []
synonym: "sodium:calcium exchange" RELATED []
xref: Reactome:REACT_102617 "Na+/Ca2+ exchanger transport, Xenopus tropicalis"
xref: Reactome:REACT_104685 "Na+/Ca2+ exchanger transport, Canis familiaris"
xref: Reactome:REACT_113595 "Na+/Ca2+ exchanger transport, Drosophila melanogaster"
xref: Reactome:REACT_115279 "Na+/Ca2+ exchanger transport, Caenorhabditis elegans"
xref: Reactome:REACT_19164 "Na+/Ca2+ exchanger transport, Homo sapiens"
xref: Reactome:REACT_29346 "Na+/Ca2+ exchanger transport, Danio rerio"
xref: Reactome:REACT_30158 "Na+/Ca2+ exchanger transport, Sus scrofa"
xref: Reactome:REACT_78566 "Na+/Ca2+ exchanger transport, Oryza sativa"
xref: Reactome:REACT_79818 "Na+/Ca2+ exchanger transport, Mus musculus"
xref: Reactome:REACT_82643 "Na+/Ca2+ exchanger transport, Arabidopsis thaliana"
xref: Reactome:REACT_82974 "Na+/Ca2+ exchanger transport, Taeniopygia guttata"
xref: Reactome:REACT_84090 "Na+/Ca2+ exchanger transport, Bos taurus"
xref: Reactome:REACT_91208 "Na+/Ca2+ exchanger transport, Rattus norvegicus"
xref: Reactome:REACT_99182 "Na+/Ca2+ exchanger transport, Gallus gallus"
is_a: GO:0015081 ! sodium ion transmembrane transporter activity
is_a: GO:0015368 ! calcium:cation antiporter activity

[Term]
id: GO:0005436
name: sodium:phosphate symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + phosphate(out) = Na+(in) + phosphate(in)." [GOC:ai]
subset: gosubset_prok
synonym: "sodium/phosphate symporter activity" EXACT []
is_a: GO:0015081 ! sodium ion transmembrane transporter activity
is_a: GO:0015114 ! phosphate ion transmembrane transporter activity
is_a: GO:0015296 ! anion:cation symporter activity

[Term]
id: GO:0005451
name: monovalent cation:proton antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monovalent cation(out) + H+(in) = monovalent cation(in) + H+(out)." [GOC:ai]
subset: gosubset_prok
synonym: "monovalent cation:hydrogen antiporter activity" EXACT []
is_a: GO:0015299 ! solute:proton antiporter activity
is_a: GO:0015491 ! cation:cation antiporter activity

[Term]
id: GO:0005452
name: inorganic anion exchanger activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion A(out) + inorganic anion B(in) = inorganic anion A(in) + inorganic anion B(out)." [GOC:mah]
xref: Reactome:REACT_101146 "Cl-/HCO3- exchanger transport, Danio rerio"
xref: Reactome:REACT_102042 "Group 2 - Cl-/HCO3- exchanger transport, Gallus gallus"
xref: Reactome:REACT_102994 "Cl-/HCO3- exchanger transport, Drosophila melanogaster"
xref: Reactome:REACT_103040 "Cl-/HCO3- exchanger transport, Gallus gallus"
xref: Reactome:REACT_103120 "Group 2 - Cl-/HCO3- exchanger transport, Taeniopygia guttata"
xref: Reactome:REACT_103901 "Cl-/HCO3- exchanger transport, Rattus norvegicus"
xref: Reactome:REACT_104303 "Cl-/HCO3- exchanger transport, Bos taurus"
xref: Reactome:REACT_104752 "Na+-driven Cl-/HCO3- exchanger transport, Rattus norvegicus"
xref: Reactome:REACT_105463 "Group 2 - Cl-/HCO3- exchanger transport, Mycobacterium tuberculosis"
xref: Reactome:REACT_105475 "Group 2 - Cl-/HCO3- exchanger transport, Rattus norvegicus"
xref: Reactome:REACT_105655 "Cl-/HCO3- exchanger transport, Xenopus tropicalis"
xref: Reactome:REACT_106810 "Group 2 - Cl-/HCO3- exchanger transport, Arabidopsis thaliana"
xref: Reactome:REACT_107121 "Group 2 - Cl-/HCO3- exchanger transport, Xenopus tropicalis"
xref: Reactome:REACT_111979 "Cl-/HCO3- exchanger transport, Caenorhabditis elegans"
xref: Reactome:REACT_112953 "Na+-driven Cl-/HCO3- exchanger transport, Dictyostelium discoideum"
xref: Reactome:REACT_114173 "Cl-/HCO3- exchanger transport, Dictyostelium discoideum"
xref: Reactome:REACT_114293 "Group 2 - Cl-/HCO3- exchanger transport, Dictyostelium discoideum"
xref: Reactome:REACT_114573 "Group 2 - Cl-/HCO3- exchanger transport, Plasmodium falciparum"
xref: Reactome:REACT_19235 "Group 2 - Cl-/HCO3- exchanger transport, Homo sapiens"
xref: Reactome:REACT_19263 "Cl-/HCO3- exchanger transport, Homo sapiens"
xref: Reactome:REACT_19291 "Na+-driven Cl-/HCO3- exchanger transport, Homo sapiens"
xref: Reactome:REACT_30319 "Group 2 - Cl-/HCO3- exchanger transport, Mus musculus"
xref: Reactome:REACT_38352 "Group 2 - Cl-/HCO3- exchanger transport, Canis familiaris"
xref: Reactome:REACT_77673 "Group 2 - Cl-/HCO3- exchanger transport, Oryza sativa"
xref: Reactome:REACT_78505 "Group 2 - Cl-/HCO3- exchanger transport, Sus scrofa"
xref: Reactome:REACT_79187 "Na+-driven Cl-/HCO3- exchanger transport, Drosophila melanogaster"
xref: Reactome:REACT_80632 "Na+-driven Cl-/HCO3- exchanger transport, Danio rerio"
xref: Reactome:REACT_81575 "Na+-driven Cl-/HCO3- exchanger transport, Taeniopygia guttata"
xref: Reactome:REACT_83070 "Na+-driven Cl-/HCO3- exchanger transport, Gallus gallus"
xref: Reactome:REACT_85300 "Cl-/HCO3- exchanger transport, Sus scrofa"
xref: Reactome:REACT_86455 "Cl-/HCO3- exchanger transport, Taeniopygia guttata"
xref: Reactome:REACT_86470 "Na+-driven Cl-/HCO3- exchanger transport, Bos taurus"
xref: Reactome:REACT_86727 "Group 2 - Cl-/HCO3- exchanger transport, Bos taurus"
xref: Reactome:REACT_87587 "Na+-driven Cl-/HCO3- exchanger transport, Caenorhabditis elegans"
xref: Reactome:REACT_90569 "Na+-driven Cl-/HCO3- exchanger transport, Mus musculus"
xref: Reactome:REACT_93454 "Na+-driven Cl-/HCO3- exchanger transport, Xenopus tropicalis"
xref: Reactome:REACT_94217 "Na+-driven Cl-/HCO3- exchanger transport, Canis familiaris"
xref: Reactome:REACT_94529 "Cl-/HCO3- exchanger transport, Mus musculus"
xref: Reactome:REACT_96775 "Na+-driven Cl-/HCO3- exchanger transport, Sus scrofa"
xref: Reactome:REACT_97540 "Group 2 - Cl-/HCO3- exchanger transport, Danio rerio"
xref: Reactome:REACT_99786 "Cl-/HCO3- exchanger transport, Canis familiaris"
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0005456
name: CMP-N-acetylneuraminate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a CMP-N-acetylneuraminate from one side of the membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "CMP-sialic acid transmembrane transporter activity" BROAD []
xref: Reactome:REACT_22111 "SLC35A1 mediates the antiport of CMP-sialic acid in exchange for CMP, Homo sapiens"
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015165 ! pyrimidine nucleotide-sugar transmembrane transporter activity
relationship: part_of GO:0015782 ! CMP-N-acetylneuraminate transport

[Term]
id: GO:0005457
name: GDP-fucose transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a GDP-fucose from one side of the membrane to the other. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
xref: Reactome:REACT_22259 "SLC35C1 mediates the transport of UDP-fucose into the Golgi lumen, Homo sapiens"
is_a: GO:0036080 ! purine nucleotide-sugar transmembrane transporter activity
relationship: part_of GO:0015783 ! GDP-fucose transport

[Term]
id: GO:0005458
name: GDP-mannose transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a GDP-mannose from one side of the membrane to the other. GDP-mannose is a substance composed of mannose in glycosidic linkage with guanosine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0036080 ! purine nucleotide-sugar transmembrane transporter activity
relationship: part_of GO:1990570 ! GDP-mannose transmembrane transport

[Term]
id: GO:0005459
name: UDP-galactose transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a UDP-galactose from one side of the membrane to the other. UDP-galactose is a substance composed of galactose in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
xref: Reactome:REACT_22299 "SLC35A2 mediates the antiport of UDP-Gal and UDP-GalNAc in exchange for UMP, Homo sapiens"
is_a: GO:0015165 ! pyrimidine nucleotide-sugar transmembrane transporter activity
relationship: part_of GO:0072334 ! UDP-galactose transmembrane transport

[Term]
id: GO:0005460
name: UDP-glucose transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a UDP-glucose from one side of the membrane to the other. UDP-glucose is a substance composed of glucose in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015165 ! pyrimidine nucleotide-sugar transmembrane transporter activity
relationship: part_of GO:0015786 ! UDP-glucose transport

[Term]
id: GO:0005461
name: UDP-glucuronic acid transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a UDP-glucuronic acid from one side of the membrane to the other. UDP-glucuronic acid is a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
xref: Reactome:REACT_103239 "UDP-glucuronate transport from the cytosol to ER lumen, Mus musculus"
xref: Reactome:REACT_108560 "UDP-glucuronate transport from the cytosol to ER lumen, Sus scrofa"
xref: Reactome:REACT_108970 "UDP-glucuronate transport from the cytosol to ER lumen, Danio rerio"
xref: Reactome:REACT_113825 "UDP-glucuronate transport from the cytosol to ER lumen, Dictyostelium discoideum"
xref: Reactome:REACT_32989 "UDP-glucuronate transport from the cytosol to ER lumen, Caenorhabditis elegans"
xref: Reactome:REACT_34308 "UDP-glucuronate transport from the cytosol to ER lumen, Oryza sativa"
xref: Reactome:REACT_6892 "UDP-glucuronate transport from the cytosol to ER lumen, Homo sapiens"
xref: Reactome:REACT_78157 "UDP-glucuronate transport from the cytosol to ER lumen, Bos taurus"
xref: Reactome:REACT_78558 "UDP-glucuronate transport from the cytosol to ER lumen, Rattus norvegicus"
xref: Reactome:REACT_78731 "UDP-glucuronate transport from the cytosol to ER lumen, Xenopus tropicalis"
xref: Reactome:REACT_79113 "UDP-glucuronate transport from the cytosol to ER lumen, Arabidopsis thaliana"
xref: Reactome:REACT_87886 "UDP-glucuronate transport from the cytosol to ER lumen, Canis familiaris"
xref: Reactome:REACT_92408 "UDP-glucuronate transport from the cytosol to ER lumen, Taeniopygia guttata"
xref: Reactome:REACT_95534 "UDP-glucuronate transport from the cytosol to ER lumen, Drosophila melanogaster"
xref: Reactome:REACT_97200 "UDP-glucuronate transport from the cytosol to ER lumen, Gallus gallus"
is_a: GO:0015165 ! pyrimidine nucleotide-sugar transmembrane transporter activity
relationship: part_of GO:0015787 ! UDP-glucuronic acid transport

[Term]
id: GO:0005462
name: UDP-N-acetylglucosamine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a UDP-N-acetylglucosamine from one side of the membrane to the other. N-acetylglucosamine is a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
xref: Reactome:REACT_22160 "SLC35A3 mediates the antiport of UDP-GlcNAc in exchange for UMP, Homo sapiens"
xref: Reactome:REACT_22323 "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen, Homo sapiens"
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015165 ! pyrimidine nucleotide-sugar transmembrane transporter activity
relationship: part_of GO:1990569 ! UDP-N-acetylglucosamine transmembrane transport

[Term]
id: GO:0005463
name: UDP-N-acetylgalactosamine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a N-acetylgalactosamine from one side of the membrane to the other. N-acetylgalactosamine is a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015165 ! pyrimidine nucleotide-sugar transmembrane transporter activity
relationship: part_of GO:0015789 ! UDP-N-acetylgalactosamine transport

[Term]
id: GO:0005464
name: UDP-xylose transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of UDP-xylose from one side of the membrane to the other. UDP-xylose is a substance composed of xylose in glycosidic linkage with uridine diphosphate." [GOC:ai]
xref: Reactome:REACT_22300 "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen, Homo sapiens"
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015165 ! pyrimidine nucleotide-sugar transmembrane transporter activity
relationship: part_of GO:0015790 ! UDP-xylose transport

[Term]
id: GO:0005468
name: obsolete small-molecule carrier or transporter
namespace: molecular_function
alt_id: GO:0005453
alt_id: GO:0005454
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it does not provide a useful functional classification.
synonym: "small-molecule carrier or transporter" EXACT []
is_obsolete: true
consider: GO:0005215

[Term]
id: GO:0005469
name: succinate:fumarate antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: succinate(out) + fumarate(in) = succinate(in) + fumarate(out)." [TC:2.A.29.13.1]
is_a: GO:0015138 ! fumarate transmembrane transporter activity
is_a: GO:0015141 ! succinate transmembrane transporter activity
is_a: GO:0015297 ! antiporter activity

[Term]
id: GO:0005471
name: ATP:ADP antiporter activity
namespace: molecular_function
alt_id: GO:0005349
def: "Catalysis of the reaction: ATP(out) + ADP(in) = ATP(in) + ADP(out)." [TC:2.A.29.1.1]
subset: gosubset_prok
synonym: "adenine nucleotide translocase" EXACT []
synonym: "ADP/ATP translocase" EXACT []
synonym: "ATP/ADP exchange" EXACT []
synonym: "ATP/ADP exchanger" EXACT []
is_a: GO:0005347 ! ATP transmembrane transporter activity
is_a: GO:0015217 ! ADP transmembrane transporter activity
is_a: GO:0015297 ! antiporter activity

[Term]
id: GO:0005472
name: FAD carrier activity
namespace: molecular_function
def: "Catalysis of the transfer of flavin adenine dinucleotide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mah]
synonym: "flavin adenine dinucleotide carrier activity" EXACT []
synonym: "flavin-adenine dinucleotide carrier activity" EXACT []
is_a: GO:0015230 ! FAD transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0005476
name: carnitine:acyl carnitine antiporter activity
namespace: molecular_function
def: "Catalysis of the reaction: carnitine (mitochondrial) + acyl carnitine (cytoplasm) = carnitine (cytoplasm) + acyl carnitine (mitochondrial)." [PMID:9032458]
synonym: "carnitine/acyl carnitine carrier activity" EXACT []
synonym: "carnitine:acyl carnitine carrier activity" EXACT []
synonym: "fatty acyl carnitine carrier" EXACT []
is_a: GO:0015297 ! antiporter activity

[Term]
id: GO:0005477
name: pyruvate secondary active transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of pyruvate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport]
synonym: "pyruvate carrier activity" RELATED []
is_a: GO:0015291 ! secondary active transmembrane transporter activity
is_a: GO:0050833 ! pyruvate transmembrane transporter activity

[Term]
id: GO:0005479
name: obsolete vacuolar assembly
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a biological process and not a molecular function.
synonym: "vacuolar assembly" EXACT []
is_obsolete: true
replaced_by: GO:0007033

[Term]
id: GO:0005480
name: obsolete vesicle transport
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a biological process and not a molecular function.
synonym: "vesicle transport" EXACT []
is_obsolete: true
replaced_by: GO:0016192

[Term]
id: GO:0005481
name: obsolete vesicle fusion
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a biological process and not a molecular function.
synonym: "vesicle fusion" EXACT []
is_obsolete: true
consider: GO:0006906
consider: GO:0007086
consider: GO:0016189
consider: GO:0016192
consider: GO:0019817

[Term]
id: GO:0005482
name: obsolete vesicle targeting
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a biological process and not a molecular function.
synonym: "vesicle targeting" EXACT []
is_obsolete: true
consider: GO:0006903
consider: GO:0016080

[Term]
id: GO:0005483
name: soluble NSF attachment protein activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with both N-ethylmaleimide-sensitive fusion protein (NSF) and a cis-SNARE complex (i.e. a SNARE complex in which all proteins are associated with the same membrane) and increasing the ATPase activity of NSF, thereby allowing ATP hydrolysis by NSF to disassemble the cis-SNARE complex." [GOC:mah, PMID:14570579, PMID:15556857]
synonym: "SNAP" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0005484
name: SNAP receptor activity
namespace: molecular_function
alt_id: GO:0005485
alt_id: GO:0005486
def: "Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579]
subset: goslim_chembl
synonym: "Q-SNARE activity" NARROW []
synonym: "R-SNARE activity" NARROW []
synonym: "SNAP-25" NARROW []
synonym: "SNARE" EXACT []
synonym: "t-SNARE activity" NARROW []
synonym: "v-SNARE activity" NARROW []
is_a: GO:0005515 ! protein binding
relationship: part_of GO:0061025 ! membrane fusion

[Term]
id: GO:0005487
name: nucleocytoplasmic transporter activity
namespace: molecular_function
def: "Enables the directed movement of substances between the nucleus and the cytoplasm of a cell." [GOC:ai]
xref: Reactome:REACT_102749 "GCK1:GKRP [cytosol] => GCK1:GKRP [nucleoplasm], Danio rerio"
xref: Reactome:REACT_114315 "GCK1:GKRP [cytosol] => GCK1:GKRP [nucleoplasm], Xenopus tropicalis"
xref: Reactome:REACT_115827 "Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus, Homo sapiens"
xref: Reactome:REACT_33526 "GCK1:GKRP [cytosol] => GCK1:GKRP [nucleoplasm], Bos taurus"
xref: Reactome:REACT_6938 "GCK1:GKRP [cytosol] => GCK1:GKRP [nucleoplasm], Homo sapiens"
xref: Reactome:REACT_83257 "GCK1:GKRP [cytosol] => GCK1:GKRP [nucleoplasm], Mus musculus"
is_a: GO:0005215 ! transporter activity
relationship: part_of GO:0006913 ! nucleocytoplasmic transport

[Term]
id: GO:0005488
name: binding
namespace: molecular_function
def: "The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]
comment: Note that this term is in the subset of terms that should not be used for direct, manual gene product annotation. Please choose a more specific child term, or request a new one if no suitable term is available. For ligands that bind to signal transducing receptors, consider the molecular function term 'receptor binding ; GO:0005102' and its children.
subset: gocheck_do_not_manually_annotate
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "ligand" NARROW []
xref: Wikipedia:Binding_(molecular)
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0005489
name: obsolete electron transporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the directed movement of electrons into, out of, within or between cells." [GOC:ai]
comment: This term was made obsolete because the activity described by the definition does not exist.
synonym: "class I cytochrome c" RELATED []
synonym: "class II cytochrome c" RELATED []
synonym: "class IIa cytochrome c" RELATED []
synonym: "class IIb cytochrome c" RELATED []
synonym: "class III cytochrome c" RELATED []
synonym: "class IV cytochrome c" RELATED []
synonym: "cytochrome b" RELATED []
synonym: "cytochrome b5" RELATED []
synonym: "cytochrome c3 (tetraheme)" RELATED []
synonym: "cytochrome c554" RELATED []
synonym: "cytochrome c7 (triheme)" RELATED []
synonym: "cytochrome d" RELATED []
synonym: "diheme class I cytochrome c" RELATED []
synonym: "electron transfer carrier" RELATED []
synonym: "electron transporter activity" EXACT []
synonym: "flavin-containing electron transporter" RELATED []
synonym: "flavodoxin" RELATED []
synonym: "high-molecular-weight cytochrome c (hexadecaheme)" RELATED []
synonym: "monoheme class I cytochrome c" RELATED []
synonym: "nonaheme cytochrome c" RELATED []
synonym: "respiratory chain cytochrome b6" RELATED []
synonym: "Rieske iron-sulfur protein" RELATED []
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0005490
name: obsolete cytochrome P450
namespace: molecular_function
def: "OBSOLETE. A cytochrome b that has a sulfur atom ligated to the iron of the prosthetic group (heme-thiolate); enzymes:typically monooxygenases acting on lipophilic substrates." [ISBN:0198547684]
comment: This term was made obsolete because its definition was changed and because it represents a gene product.
synonym: "cytochrome P450" EXACT []
is_obsolete: true

[Term]
id: GO:0005496
name: steroid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene." [GOC:jl, ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0008289 ! lipid binding
is_a: GO:0097159 ! organic cyclic compound binding

[Term]
id: GO:0005497
name: androgen binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any androgen, male sex hormones." [CHEBI:50113, GOC:jl]
is_a: GO:0005496 ! steroid binding
is_a: GO:0042562 ! hormone binding

[Term]
id: GO:0005499
name: vitamin D binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)." [CHEBI:27300, GOC:mah, ISBN:0471331309]
synonym: "calciferol binding" NARROW []
synonym: "cholecalciferol binding" NARROW []
synonym: "ergocalciferol binding" NARROW []
is_a: GO:0005496 ! steroid binding
is_a: GO:0019842 ! vitamin binding
is_a: GO:0043178 ! alcohol binding

[Term]
id: GO:0005500
name: juvenile hormone binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with juvenile hormone, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:jl, ISBN:0198506732]
is_a: GO:0019840 ! isoprenoid binding
is_a: GO:0042562 ! hormone binding

[Term]
id: GO:0005501
name: retinoid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity." [GOC:jl, ISBN:0198506732]
is_a: GO:0019840 ! isoprenoid binding

[Term]
id: GO:0005502
name: 11-cis retinal binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with 11-cis retinal, an isomer of retinal that plays an important role in the visual process in most vertebrates. 11-cis retinal combines with opsin in the rods (scotopsin) to form rhodopsin or visual purple. Retinal is one of the three compounds that makes up vitamin A." [CHEBI:16066]
synonym: "11-cis retinaldehyde binding" EXACT []
synonym: "11-cis-retinal binding" NARROW [CHEBI:16066]
synonym: "vitamin A binding" BROAD []
is_a: GO:0016918 ! retinal binding

[Term]
id: GO:0005503
name: all-trans retinal binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with all-trans retinal, a compound that plays an important role in the visual process in most vertebrates. All-trans retinal (trans r., visual yellow) results from the bleaching of rhodopsin by light, in which the 11-cis form is converted to the all-trans form. Retinal is one of the forms of vitamin A." [CHEBI:17898, GOC:curators]
synonym: "all-trans retinaldehyde binding" EXACT []
synonym: "trans retinal binding" EXACT []
synonym: "visual yellow binding" EXACT []
synonym: "vitamin A binding" BROAD []
synonym: "xanthopsin" RELATED []
is_a: GO:0016918 ! retinal binding

[Term]
id: GO:0005504
name: fatty acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0008289 ! lipid binding
is_a: GO:0033293 ! monocarboxylic acid binding

[Term]
id: GO:0005505
name: obsolete heavy metal binding
namespace: molecular_function
def: "OBSOLETE. Interacting selectively with a heavy metal, a metal that can form a coordination bond with a protein, as opposed to an alkali or alkaline-earth metal that can only form an ionic bond; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn." [GOC:kd, GOC:mah]
comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information).
synonym: "heavy metal binding" EXACT []
is_obsolete: true
consider: GO:0046872

[Term]
id: GO:0005506
name: iron ion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
subset: gosubset_prok
synonym: "iron binding" EXACT []
is_a: GO:0046914 ! transition metal ion binding

[Term]
id: GO:0005507
name: copper ion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with copper (Cu) ions." [GOC:ai]
subset: gosubset_prok
synonym: "copper binding" EXACT []
synonym: "copper/cadmium binding" BROAD []
is_a: GO:0046914 ! transition metal ion binding

[Term]
id: GO:0005508
name: obsolete copper/cadmium binding
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a composite function.
synonym: "copper/cadmium binding" EXACT []
is_obsolete: true
consider: GO:0005507
consider: GO:0046870

[Term]
id: GO:0005509
name: calcium ion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
subset: gosubset_prok
synonym: "calcium ion storage activity" RELATED []
xref: Reactome:REACT_20509 "Exocytosis of Insulin, Mus musculus"
is_a: GO:0046872 ! metal ion binding

[Term]
id: GO:0005513
name: detection of calcium ion
namespace: biological_process
def: "The series of events in which a calcium ion stimulus is received by a cell and converted into a molecular signal." [GOC:pg]
synonym: "Ca2+ ion detection" EXACT []
synonym: "calcium ion detection" EXACT []
synonym: "calcium ion sensing" EXACT []
synonym: "detection of Ca2+ ion" EXACT []
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0051592 ! response to calcium ion

[Term]
id: GO:0005514
name: obsolete calcium ion storage activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a biological process.
synonym: "calcium ion storage activity" EXACT []
is_obsolete: true
consider: GO:0005509
consider: GO:0051208

[Term]
id: GO:0005515
name: protein binding
namespace: molecular_function
alt_id: GO:0045308
def: "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "alpha-2 macroglobulin receptor-associated protein activity" RELATED []
synonym: "protein amino acid binding" EXACT []
synonym: "protein degradation tagging activity" RELATED []
synonym: "protein folding chaperone" NARROW [GOC:dph, GOC:mah, GOC:tb]
synonym: "protein tagging activity" RELATED []
xref: Reactome:REACT_100287 "Formation of the IGF:IGFBP-4 Complex, Canis familiaris"
xref: Reactome:REACT_101129 "Formation of the IGF:IGFBP-3:ALS Complex, Rattus norvegicus"
xref: Reactome:REACT_102084 "Formation of the IGF:IGFBP-5:ALS Complex, Mus musculus"
xref: Reactome:REACT_102457 "An anchoring protein, SARA, recruits SMAD2/3, Canis familiaris"
xref: Reactome:REACT_103972 "Type II receptor recruits type I receptor, Xenopus tropicalis"
xref: Reactome:REACT_104029 "Formation of the IGF:IGFBP-6 Complex, Bos taurus"
xref: Reactome:REACT_104599 "Type II receptor recruits type I receptor, Sus scrofa"
xref: Reactome:REACT_105776 "Formation of the IGF:IGFBP-3:ALS Complex, Danio rerio"
xref: Reactome:REACT_105895 "Formation of the IGF:IGFBP-4 Complex, Bos taurus"
xref: Reactome:REACT_106168 "Formation of the IGF:IGFBP-2 Complex, Bos taurus"
xref: Reactome:REACT_106189 "Formation of the IGF:IGFBP-5:ALS Complex, Gallus gallus"
xref: Reactome:REACT_107402 "Formation of the IGF:IGFBP-4 Complex, Mus musculus"
xref: Reactome:REACT_108283 "Formation of the IGF:IGFBP-4 Complex, Xenopus tropicalis"
xref: Reactome:REACT_109392 "Formation of the IGF:IGFBP-3:ALS Complex, Gallus gallus"
xref: Reactome:REACT_110419 "Type II receptor recruits type I receptor, Bos taurus"
xref: Reactome:REACT_110570 "Formation of the IGF:IGFBP-3:ALS Complex, Sus scrofa"
xref: Reactome:REACT_15321 "Formation of the IGF:IGFBP-1 Complex, Homo sapiens"
xref: Reactome:REACT_15325 "Formation of the IGF:IGFBP-4 Complex, Homo sapiens"
xref: Reactome:REACT_15355 "Formation of the IGF:IGFBP-5:ALS Complex, Homo sapiens"
xref: Reactome:REACT_15417 "Formation of the IGF:IGFBP-3:ALS Complex, Homo sapiens"
xref: Reactome:REACT_15419 "Formation of the IGF:IGFBP-2 Complex, Homo sapiens"
xref: Reactome:REACT_15506 "Formation of the IGF:IGFBP-6 Complex, Homo sapiens"
xref: Reactome:REACT_15541 "Traversal of the cortical actin network and docking at plasma membrane, Homo sapiens"
xref: Reactome:REACT_20509 "Exocytosis of Insulin, Mus musculus"
xref: Reactome:REACT_20539 "Traversal of the cortical actin network., Mus musculus"
xref: Reactome:REACT_28794 "Formation of the IGF:IGFBP-4 Complex, Sus scrofa"
xref: Reactome:REACT_30571 "Formation of the IGF:IGFBP-6 Complex, Danio rerio"
xref: Reactome:REACT_30672 "Formation of the IGF:IGFBP-2 Complex, Taeniopygia guttata"
xref: Reactome:REACT_31305 "Formation of the IGF:IGFBP-3:ALS Complex, Taeniopygia guttata"
xref: Reactome:REACT_31537 "Formation of the IGF:IGFBP-6 Complex, Rattus norvegicus"
xref: Reactome:REACT_31641 "Type II receptor recruits type I receptor, Danio rerio"
xref: Reactome:REACT_31648 "An anchoring protein, SARA, recruits SMAD2/3, Mus musculus"
xref: Reactome:REACT_32973 "Formation of the IGF:IGFBP-1 Complex, Canis familiaris"
xref: Reactome:REACT_33135 "An anchoring protein, SARA, recruits SMAD2/3, Rattus norvegicus"
xref: Reactome:REACT_34719 "Formation of the IGF:IGFBP-1 Complex, Danio rerio"
xref: Reactome:REACT_6923 "An anchoring protein, SARA, recruits SMAD2/3, Homo sapiens"
xref: Reactome:REACT_6945 "Type II receptor recruits type I receptor, Homo sapiens"
xref: Reactome:REACT_78382 "Formation of the IGF:IGFBP-1 Complex, Mus musculus"
xref: Reactome:REACT_78466 "Formation of the IGF:IGFBP-6 Complex, Canis familiaris"
xref: Reactome:REACT_79634 "Formation of the IGF:IGFBP-5:ALS Complex, Canis familiaris"
xref: Reactome:REACT_80470 "Formation of the IGF:IGFBP-1 Complex, Rattus norvegicus"
xref: Reactome:REACT_80778 "Type II receptor recruits type I receptor, Mus musculus"
xref: Reactome:REACT_83147 "Type II receptor recruits type I receptor, Rattus norvegicus"
xref: Reactome:REACT_83165 "Formation of the IGF:IGFBP-5:ALS Complex, Sus scrofa"
xref: Reactome:REACT_83532 "Formation of the IGF:IGFBP-2 Complex, Xenopus tropicalis"
xref: Reactome:REACT_85250 "Formation of the IGF:IGFBP-2 Complex, Canis familiaris"
xref: Reactome:REACT_85858 "Formation of the IGF:IGFBP-2 Complex, Gallus gallus"
xref: Reactome:REACT_85975 "An anchoring protein, SARA, recruits SMAD2/3, Danio rerio"
xref: Reactome:REACT_87187 "An anchoring protein, SARA, recruits SMAD2/3, Xenopus tropicalis"
xref: Reactome:REACT_87374 "Formation of the IGF:IGFBP-6 Complex, Sus scrofa"
xref: Reactome:REACT_87652 "Formation of the IGF:IGFBP-5:ALS Complex, Bos taurus"
xref: Reactome:REACT_88068 "Formation of the IGF:IGFBP-3:ALS Complex, Canis familiaris"
xref: Reactome:REACT_88138 "Formation of the IGF:IGFBP-5:ALS Complex, Danio rerio"
xref: Reactome:REACT_88223 "Formation of the IGF:IGFBP-1 Complex, Sus scrofa"
xref: Reactome:REACT_89261 "Formation of the IGF:IGFBP-4 Complex, Taeniopygia guttata"
xref: Reactome:REACT_90027 "Formation of the IGF:IGFBP-2 Complex, Rattus norvegicus"
xref: Reactome:REACT_90105 "Formation of the IGF:IGFBP-1 Complex, Xenopus tropicalis"
xref: Reactome:REACT_90666 "An anchoring protein, SARA, recruits SMAD2/3, Sus scrofa"
xref: Reactome:REACT_91560 "Type II receptor recruits type I receptor, Canis familiaris"
xref: Reactome:REACT_92029 "Formation of the IGF:IGFBP-4 Complex, Rattus norvegicus"
xref: Reactome:REACT_93175 "Formation of the IGF:IGFBP-1 Complex, Gallus gallus"
xref: Reactome:REACT_93938 "Formation of the IGF:IGFBP-5:ALS Complex, Rattus norvegicus"
xref: Reactome:REACT_94522 "Formation of the IGF:IGFBP-5:ALS Complex, Taeniopygia guttata"
xref: Reactome:REACT_94808 "Formation of the IGF:IGFBP-6 Complex, Mus musculus"
xref: Reactome:REACT_95241 "Formation of the IGF:IGFBP-3:ALS Complex, Mus musculus"
xref: Reactome:REACT_95561 "Formation of the IGF:IGFBP-5:ALS Complex, Xenopus tropicalis"
xref: Reactome:REACT_95647 "Formation of the IGF:IGFBP-3:ALS Complex, Bos taurus"
xref: Reactome:REACT_96236 "Formation of the IGF:IGFBP-2 Complex, Mus musculus"
xref: Reactome:REACT_96264 "Formation of the IGF:IGFBP-2 Complex, Danio rerio"
xref: Reactome:REACT_98028 "Formation of the IGF:IGFBP-1 Complex, Taeniopygia guttata"
xref: Reactome:REACT_98807 "An anchoring protein, SARA, recruits SMAD2/3, Bos taurus"
is_a: GO:0005488 ! binding

[Term]
id: GO:0005516
name: calmodulin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc]
subset: goslim_chembl
subset: gosubset_prok
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0005517
name: obsolete calmodulin inhibitor activity
namespace: molecular_function
def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:tb]
comment: This term was made obsolete because it refers to a non-existent molecular function term, 'calmodulin activity'.
synonym: "calmodulin inhibitor activity" EXACT []
is_obsolete: true
consider: GO:0005516

[Term]
id: GO:0005518
name: collagen binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%)." [GOC:ai, ISBN:0198506732]
is_a: GO:0032403 ! protein complex binding

[Term]
id: GO:0005519
name: cytoskeletal regulatory protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any protein involved in modulating the reorganization of the cytoskeleton." [GOC:go_curators, PMID:15163540]
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0005520
name: insulin-like growth factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an insulin-like growth factor, any member of a group of polypeptides that are structurally homologous to insulin and share many of its biological activities, but are immunologically distinct from it." [ISBN:0198506732]
subset: goslim_chembl
synonym: "IGF binding" EXACT []
is_a: GO:0019838 ! growth factor binding

[Term]
id: GO:0005521
name: lamin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with lamin; any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope." [GOC:jl, ISBN:0198506732]
synonym: "lamin/chromatin binding" BROAD []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0005522
name: profilin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with profilin, an actin-binding protein that forms a complex with G-actin and prevents it from polymerizing to form F-actin." [ISBN:0721662544]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0005523
name: tropomyosin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle." [GOC:curators, ISBN:0815316194]
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0005524
name: ATP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
subset: gosubset_prok
xref: Reactome:REACT_102029 "Closing of Inward Rectifying, ATP-sensitive Potassium Channels (KATP channels), Bos taurus"
xref: Reactome:REACT_107997 "Closing of Inward Rectifying, ATP-sensitive Potassium Channels (KATP channels), Taeniopygia guttata"
xref: Reactome:REACT_115254 "Closing of Inward Rectifying, ATP-sensitive Potassium Channels (KATP channels), Drosophila melanogaster"
xref: Reactome:REACT_16883 "Closing of Inward Rectifying, ATP-sensitive Potassium Channels (KATP channels), Homo sapiens"
xref: Reactome:REACT_29298 "Closing of Inward Rectifying, ATP-sensitive Potassium Channels (KATP channels), Danio rerio"
xref: Reactome:REACT_79910 "Closing of Inward Rectifying, ATP-sensitive Potassium Channels (KATP channels), Gallus gallus"
xref: Reactome:REACT_85335 "Closing of Inward Rectifying, ATP-sensitive Potassium Channels (KATP channels), Canis familiaris"
xref: Reactome:REACT_93991 "Closing of Inward Rectifying, ATP-sensitive Potassium Channels (KATP channels), Mus musculus"
xref: Reactome:REACT_99051 "Closing of Inward Rectifying, ATP-sensitive Potassium Channels (KATP channels), Sus scrofa"
xref: Reactome:REACT_99955 "Closing of Inward Rectifying, ATP-sensitive Potassium Channels (KATP channels), Rattus norvegicus"
is_a: GO:0032550 ! purine ribonucleoside binding
is_a: GO:0032559 ! adenyl ribonucleotide binding
is_a: GO:0035639 ! purine ribonucleoside triphosphate binding

[Term]
id: GO:0005525
name: GTP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
subset: gosubset_prok
xref: Reactome:REACT_100336 "The receptor:G-protein complex binds GTP, Xenopus tropicalis"
xref: Reactome:REACT_101169 "The receptor:G-protein complex binds GTP, Rattus norvegicus"
xref: Reactome:REACT_15491 "The receptor:G-protein complex binds GTP, Homo sapiens"
xref: Reactome:REACT_28426 "The receptor:G-protein complex binds GTP, Sus scrofa"
xref: Reactome:REACT_32895 "The receptor:G-protein complex binds GTP, Taeniopygia guttata"
xref: Reactome:REACT_84605 "The receptor:G-protein complex binds GTP, Gallus gallus"
xref: Reactome:REACT_84948 "The receptor:G-protein complex binds GTP, Bos taurus"
xref: Reactome:REACT_87202 "The receptor:G-protein complex binds GTP, Canis familiaris"
xref: Reactome:REACT_87916 "The receptor:G-protein complex binds GTP, Danio rerio"
xref: Reactome:REACT_90887 "The receptor:G-protein complex binds GTP, Mus musculus"
is_a: GO:0032550 ! purine ribonucleoside binding
is_a: GO:0032561 ! guanyl ribonucleotide binding
is_a: GO:0035639 ! purine ribonucleoside triphosphate binding

[Term]
id: GO:0005527
name: macrolide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a macrolide, any of a large group of structurally related antibiotics produced by Streptomyces species." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0008144 ! drug binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding

[Term]
id: GO:0005528
name: FK506 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the 23-membered macrolide lactone FK506." [GOC:jl]
synonym: "FK506-sensitive peptidyl-prolyl cis-trans isomerase" RELATED []
is_a: GO:0005527 ! macrolide binding

[Term]
id: GO:0005530
name: obsolete lectin
namespace: molecular_function
def: "OBSOLETE. Lectins are proteins obtained particularly from the seeds of leguminous plants, but also from many other plant and animal sources, that have binding sites for specific mono or oligosaccharides in cell walls or membranes. They thereby change the physiology of the membrane to cause agglutination, mitosis, or other biochemical changes in the cell." [GOC:curators]
comment: This term was made obsolete because it refers to a class of gene products.
synonym: "lectin" EXACT []
is_obsolete: true
consider: GO:0007157
consider: GO:0030246

[Term]
id: GO:0005531
name: obsolete galactose binding lectin
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it refers to a class of gene products.
synonym: "galactose binding lectin" EXACT []
is_obsolete: true
consider: GO:0005534
consider: GO:0007157

[Term]
id: GO:0005532
name: obsolete mannose binding lectin
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it refers to a class of gene products.
synonym: "mannose binding lectin" EXACT []
synonym: "mannose receptor" RELATED []
is_obsolete: true
consider: GO:0005537
consider: GO:0007157

[Term]
id: GO:0005533
name: obsolete N-acetylgalactosamine lectin
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it refers to a class of gene products.
synonym: "N-acetylgalactosamine lectin" EXACT []
is_obsolete: true
consider: GO:0007157
consider: GO:0046871

[Term]
id: GO:0005534
name: galactose binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the aldohexose galactose (galacto-hexose), a common constituent of many oligo- and polysaccharides." [CHEBI:28260, GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "galactose binding lectin" RELATED []
is_a: GO:0048029 ! monosaccharide binding

[Term]
id: GO:0005536
name: glucose binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the D- or L-enantiomer of glucose." [CHEBI:17234, GOC:jl]
subset: gosubset_prok
is_a: GO:0048029 ! monosaccharide binding

[Term]
id: GO:0005537
name: mannose binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with mannose, a monosaccharide hexose, stereoisomeric with glucose, that occurs naturally only in polymerized forms called mannans." [CHEBI:37684, GOC:jl, ISBN:0192800981]
subset: goslim_chembl
subset: gosubset_prok
synonym: "mannose binding lectin" RELATED []
xref: Reactome:REACT_25176 "Transport of glycoproteins with Man8 (or Man9) N-glycans to the Golgi, Homo sapiens"
is_a: GO:0048029 ! monosaccharide binding

[Term]
id: GO:0005539
name: glycosaminoglycan binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues." [GOC:jl, ISBN:0198506732]
subset: goslim_chembl
subset: gosubset_prok
is_a: GO:0097367 ! carbohydrate derivative binding

[Term]
id: GO:0005540
name: hyaluronic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine." [CHEBI:16336, GOC:jl]
synonym: "hyaluronan binding" EXACT []
is_a: GO:0005539 ! glycosaminoglycan binding

[Term]
id: GO:0005541
name: obsolete acyl-CoA or acyl binding
namespace: molecular_function
def: "OBSOLETE. Interacting selectively with acyl-CoA or acyl, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group, or any group formally derived by removal of a hydroxyl group from the acid function of an organic acid." [GOC:jl, ISBN:0198506732]
comment: This term was made obsolete because it was replaced by more appropriate terms.
synonym: "acyl-CoA or acyl binding" EXACT []
is_obsolete: true
consider: GO:0000035
consider: GO:0000062

[Term]
id: GO:0005542
name: folic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "folate binding" EXACT []
synonym: "vitamin B9 binding" EXACT []
synonym: "vitamin M binding" EXACT []
is_a: GO:0016597 ! amino acid binding
is_a: GO:0019842 ! vitamin binding
is_a: GO:0033218 ! amide binding
is_a: GO:0072341 ! modified amino acid binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding

[Term]
id: GO:0005543
name: phospholipid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0008289 ! lipid binding
is_a: GO:0043168 ! anion binding

[Term]
id: GO:0005544
name: calcium-dependent phospholipid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium." [GOC:jl]
subset: gosubset_prok
is_a: GO:0005543 ! phospholipid binding

[Term]
id: GO:0005545
name: 1-phosphatidylinositol binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [ISBN:0198506732]
is_a: GO:0035091 ! phosphatidylinositol binding

[Term]
id: GO:0005546
name: phosphatidylinositol-4,5-bisphosphate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions." [GOC:bf, GOC:jl]
synonym: "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate binding" EXACT [CHEBI:18348]
synonym: "phosphatidylinositol 4,5-bisphosphate binding" EXACT [GOC:ebc]
synonym: "PIP2 binding" BROAD [CHEBI:18348]
synonym: "PtdIns(4,5)P2 binding" EXACT [GOC:bf]
is_a: GO:1902936 ! phosphatidylinositol bisphosphate binding

[Term]
id: GO:0005547
name: phosphatidylinositol-3,4,5-trisphosphate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions." [GOC:bf, GOC:jl]
synonym: "PIP3 binding" EXACT [GOC:bf]
is_a: GO:1901981 ! phosphatidylinositol phosphate binding

[Term]
id: GO:0005548
name: phospholipid transporter activity
namespace: molecular_function
alt_id: GO:0008497
def: "Enables the directed movement of phospholipids into, out of or within a cell, or between cells. Phospholipids are a class of lipids containing phosphoric acid as a mono- or diester." [GOC:ai, ISBN:0198506732]
subset: gosubset_prok
xref: Reactome:REACT_100966 "ABCA7:Apo1A-mediated phospholipid efflux, Bos taurus"
xref: Reactome:REACT_101672 "ABCA7:Apo1A-mediated phospholipid efflux, Gallus gallus"
xref: Reactome:REACT_103068 "ABCA1-mediated transport of intracellular phospholipid to the cell surface, Xenopus tropicalis"
xref: Reactome:REACT_103608 "ABCA1-mediated transport of intracellular phospholipid to the cell surface, Canis familiaris"
xref: Reactome:REACT_105419 "ABCA1-mediated transport of intracellular phospholipid to the cell surface, Bos taurus"
xref: Reactome:REACT_13627 "ABCA1-mediated transport of intracellular phospholipid to the cell surface, Homo sapiens"
xref: Reactome:REACT_15367 "ABCA7:Apo1A-mediated phospholipid efflux, Homo sapiens"
xref: Reactome:REACT_80194 "ABCA7:Apo1A-mediated phospholipid efflux, Danio rerio"
xref: Reactome:REACT_83722 "ABCA1-mediated transport of intracellular phospholipid to the cell surface, Mus musculus"
xref: Reactome:REACT_87324 "ABCA1-mediated transport of intracellular phospholipid to the cell surface, Sus scrofa"
xref: Reactome:REACT_91778 "ABCA1-mediated transport of intracellular phospholipid to the cell surface, Gallus gallus"
xref: Reactome:REACT_95207 "ABCA7:Apo1A-mediated phospholipid efflux, Mus musculus"
xref: Reactome:REACT_95532 "ABCA1-mediated transport of intracellular phospholipid to the cell surface, Danio rerio"
xref: Reactome:REACT_96484 "ABCA7:Apo1A-mediated phospholipid efflux, Canis familiaris"
is_a: GO:0005319 ! lipid transporter activity
relationship: part_of GO:0015914 ! phospholipid transport

[Term]
id: GO:0005549
name: odorant binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0005550
name: pheromone binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a pheromone, a substance, or characteristic mixture of substances, that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [GOC:ai]
is_a: GO:0005549 ! odorant binding

[Term]
id: GO:0005551
name: obsolete ubiquitin
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
consider: GO:0016567
consider: GO:0031386

[Term]
id: GO:0005552
name: obsolete polyubiquitin
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a gene product and not a molecular function.
synonym: "polyubiquitin" EXACT []
is_obsolete: true
consider: GO:0000209

[Term]
id: GO:0005553
name: obsolete ubiquitin-ribosomal protein fusion protein
namespace: molecular_function
def: "OBSOLETE. A protein encoded by some ubiquitin genes which consists of a single copy of ubiquitin fused to a ribosomal protein." [ISBN:0198506732]
comment: This term was made obsolete because it describes a gene product.
synonym: "ubiquitin-ribosomal protein fusion protein" EXACT []
is_obsolete: true

[Term]
id: GO:0005555
name: obsolete blood group antigen
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity.
synonym: "blood group antigen" EXACT []
is_obsolete: true

[Term]
id: GO:0005557
name: obsolete lymphocyte antigen
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity.
synonym: "lymphocyte antigen" EXACT []
is_obsolete: true

[Term]
id: GO:0005558
name: obsolete minor histocompatibility antigen
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity.
synonym: "minor histocompatibility antigen" EXACT []
is_obsolete: true

[Term]
id: GO:0005559
name: obsolete ribozyme
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
synonym: "ribozyme" EXACT []
is_obsolete: true

[Term]
id: GO:0005561
name: obsolete nucleic acid
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
synonym: "nucleic acid" EXACT []
is_obsolete: true

[Term]
id: GO:0005562
name: obsolete RNA
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
synonym: "RNA" EXACT []
is_obsolete: true

[Term]
id: GO:0005563
name: obsolete transfer RNA
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "transfer RNA" EXACT []
is_obsolete: true
replaced_by: GO:0030533

[Term]
id: GO:0005564
name: obsolete cytosolic tRNA
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
synonym: "cytosolic tRNA" EXACT []
is_obsolete: true

[Term]
id: GO:0005565
name: obsolete mitochondrial tRNA
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: Note that this term was deleted from GO rather than being made obsolete and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
synonym: "mitochondrial tRNA" EXACT []
is_obsolete: true

[Term]
id: GO:0005566
name: obsolete ribosomal RNA
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "ribosomal RNA" EXACT []
is_obsolete: true
consider: GO:0003735
consider: GO:0005840

[Term]
id: GO:0005567
name: obsolete cytosolic ribosomal RNA
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
synonym: "cytosolic ribosomal RNA" EXACT []
is_obsolete: true

[Term]
id: GO:0005568
name: obsolete mitochondrial rRNA
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: Note that this term was deleted from GO rather than being made obsolete and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
synonym: "mitochondrial rRNA" EXACT []
is_obsolete: true

[Term]
id: GO:0005569
name: obsolete small nucleolar RNA
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents gene products.
synonym: "small nucleolar RNA" EXACT []
is_obsolete: true
consider: GO:0030555

[Term]
id: GO:0005570
name: obsolete small nuclear RNA
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents gene products.
synonym: "small nuclear RNA" EXACT []
is_obsolete: true
consider: GO:0000375
consider: GO:0017069

[Term]
id: GO:0005571
name: obsolete untranslated RNA
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
synonym: "untranslated RNA" EXACT []
is_obsolete: true

[Term]
id: GO:0005572
name: obsolete RNA polymerase II transcribed untranslated RNA
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
synonym: "RNA polymerase II transcribed untranslated RNA" EXACT []
is_obsolete: true

[Term]
id: GO:0005573
name: obsolete telomerase RNA
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:krc]
comment: This term was made obsolete because it represents a gene product.
synonym: "telomerase RNA" EXACT []
is_obsolete: true
replaced_by: GO:0000332

[Term]
id: GO:0005574
name: obsolete DNA
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
synonym: "DNA" EXACT []
is_obsolete: true

[Term]
id: GO:0005575
name: cellular_component
namespace: cellular_component
alt_id: GO:0008372
def: "The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together." [GOC:go_curators, NIF_Subcellular:sao-1337158144]
comment: Note that, in addition to forming the root of the cellular component ontology, this term is recommended for use for the annotation of gene products whose cellular component is unknown. Note that when this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this.
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "cell or subcellular entity" EXACT []
synonym: "cellular component" EXACT []
synonym: "subcellular entity" RELATED [NIF_Subcellular:nlx_subcell_100315]
xref: NIF_Subcellular:sao-1337158144
xref: NIF_Subcellular:sao1337158144

[Term]
id: GO:0005576
name: extracellular region
namespace: cellular_component
def: "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
comment: Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term 'extracellular space ; GO:0005615'.
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "extracellular" EXACT []
xref: Wikipedia:Extracellular
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0005577
name: fibrinogen complex
namespace: cellular_component
def: "A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds." [ISBN:0198547684]
synonym: "fibrinogen" EXACT []
synonym: "fibrinogen alpha chain" NARROW []
synonym: "fibrinogen beta chain" NARROW []
synonym: "fibrinogen gamma chain" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0005578
name: proteinaceous extracellular matrix
namespace: cellular_component
def: "A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus." [GOC:mtg_sensu, ISBN:0198547684]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_plant
is_a: GO:0031012 ! extracellular matrix
is_a: GO:0044421 ! extracellular region part

[Term]
id: GO:0005579
name: membrane attack complex
namespace: cellular_component
def: "A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow." [GOC:add, ISBN:0198547684, ISBN:068340007X, ISBN:0781735149]
synonym: "MAC" EXACT []
synonym: "membrane attack complex protein alphaM chain" NARROW []
synonym: "membrane attack complex protein beta2 chain" NARROW []
synonym: "TCC" EXACT []
synonym: "terminal complement complex" EXACT []
xref: Wikipedia:Complement_membrane_attack_complex
is_a: GO:0046930 ! pore complex
is_a: GO:0098797 ! plasma membrane protein complex
relationship: part_of GO:0005887 ! integral component of plasma membrane

[Term]
id: GO:0005580
name: obsolete membrane attack complex protein alphaM chain
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "membrane attack complex protein alphaM chain" EXACT []
is_obsolete: true
replaced_by: GO:0005579

[Term]
id: GO:0005581
name: collagen trimer
namespace: cellular_component
def: "A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911]
xref: Wikipedia:Collagen
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0005582
name: collagen type XV trimer
namespace: cellular_component
def: "A collagen homotrimer of alpha1(XV) chains; a chondroitin sulfate proteoglycan often found in specialized basement membranes where it bridges between fibrils." [PMID:11158616, PMID:11937714, PMID:21421911]
is_a: GO:0098651 ! basement membrane collagen trimer
relationship: part_of GO:0005604 ! basement membrane

[Term]
id: GO:0005583
name: fibrillar collagen trimer
namespace: cellular_component
def: "Any triple helical collagen trimer that forms fibrils." [GOC:mah, ISBN:0721639976, PMID:21421911]
is_a: GO:0005581 ! collagen trimer
is_a: GO:0044420 ! extracellular matrix component
is_a: GO:0044421 ! extracellular region part
intersection_of: GO:0005581 ! collagen trimer
intersection_of: part_of GO:0098643 ! banded collagen fibril
disjoint_from: GO:0005598 ! short-chain collagen trimer
disjoint_from: GO:0030936 ! transmembrane collagen trimer
relationship: part_of GO:0005578 ! proteinaceous extracellular matrix
relationship: part_of GO:0098643 ! banded collagen fibril

[Term]
id: GO:0005584
name: collagen type I trimer
namespace: cellular_component
def: "A collagen trimer containing alpha(I) chains. The most common form of type I collagen is a heterotrimer containing two alpha1(I) chains and one alpha2(I) chain; homotrimers containing three alpha1(I) chains are also found. Type I collagen triple helices associate to form banded fibrils." [GOC:mah, GOC:sl, ISBN:0721639976]
xref: Wikipedia:Collagen_type_I
is_a: GO:0005583 ! fibrillar collagen trimer

[Term]
id: GO:0005585
name: collagen type II trimer
namespace: cellular_component
def: "A collagen homotrimer of alpha1(II) chains; type II collagen triple helices associate to form fibrils." [ISBN:0721639976]
xref: Wikipedia:Collagen_type_II
is_a: GO:0005583 ! fibrillar collagen trimer

[Term]
id: GO:0005586
name: collagen type III trimer
namespace: cellular_component
def: "A collagen homotrimer of alpha1(III) chains; type III collagen triple helices associate to form fibrils." [ISBN:0721639976]
is_a: GO:0005583 ! fibrillar collagen trimer

[Term]
id: GO:0005587
name: collagen type IV trimer
namespace: cellular_component
def: "A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form 3 dimensional nets within basement membranes." [ISBN:0721639976, PMID:19693541, PMID:21421911]
xref: Wikipedia:Collagen_type_IV
is_a: GO:0098642 ! network-forming collagen trimer
is_a: GO:0098651 ! basement membrane collagen trimer
relationship: part_of GO:0005604 ! basement membrane
relationship: part_of GO:0098645 ! collagen network

[Term]
id: GO:0005588
name: collagen type V trimer
namespace: cellular_component
def: "A collagen heterotrimer containing type V alpha chains; [alpha1(V)]2alpha2(V) and alpha1(V)alpha2(V)alpha3(V) trimers have been observed; type V collagen triple helices associate to form fibrils." [ISBN:0721639976]
is_a: GO:0005583 ! fibrillar collagen trimer

[Term]
id: GO:0005589
name: collagen type VI trimer
namespace: cellular_component
def: "A collagen heterotrimer containing type VI alpha chains in alpha1(VI)alpha2(VI)alpha3(VI) trimers; type VI collagen triple helices associate to form beaded fibrils." [ISBN:0721639976, PMID:19693541, PMID:21421911]
is_a: GO:0005581 ! collagen trimer
is_a: GO:0044420 ! extracellular matrix component
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0098647 ! collagen beaded filament

[Term]
id: GO:0005590
name: collagen type VII trimer
namespace: cellular_component
def: "A collagen homotrimer of alpha1(VII) chains; type VII collagen triple helices form antiparallel dimer, which in turn associate laterally to form anchoring fibrils that connect type IV collagen in the basal lamina to plaques in the underlying connective tissue. It binds laminin." [ISBN:0721639976] {comment="PMID:19693541"}
is_a: GO:0030934 ! anchoring collagen complex
relationship: part_of GO:0098648 ! collagen anchoring fibril
relationship: part_of GO:0098652 ! collagen type VII anchoring fibril

[Term]
id: GO:0005591
name: collagen type VIII trimer
namespace: cellular_component
def: "A collagen heterotrimer containing type VIII alpha chains; [alpha1(VIII)2]alpha2(VIII) and alpha1(VIII)[alpha2(VIII)]2 trimers have been observed; type VIII collagen triple helices associate to form regular hexagonal nets." [ISBN:0721639976, PMID:21421911]
is_a: GO:0005598 ! short-chain collagen trimer
is_a: GO:0030935 ! sheet-forming collagen trimer
is_a: GO:0098651 ! basement membrane collagen trimer
relationship: part_of GO:0005604 ! basement membrane
relationship: part_of GO:0098646 ! collagen sheet

[Term]
id: GO:0005592
name: collagen type XI trimer
namespace: cellular_component
def: "A collagen heterotrimer containing type XI alpha chains in alpha1(XI)alpha2(XI)alpha3(XI) trimers; type XI collagen triple helices associate to form fibrils." [ISBN:0721639976]
is_a: GO:0005583 ! fibrillar collagen trimer

[Term]
id: GO:0005593
name: FACIT collagen trimer
namespace: cellular_component
def: "A collagen trimer that associates with collagen fibrils and consists of collagen monomers that contain two or more relatively short triple-helical domains connected by non-triple-helical sequences." [ISBN:0198599587, PMID:21421911]
comment: The acronym FACIT stands for fibril-associated collagen with interrupted triple helix.
xref: Wikipedia:FACIT_collagen
is_a: GO:0005581 ! collagen trimer

[Term]
id: GO:0005594
name: collagen type IX trimer
namespace: cellular_component
def: "A collagen heterotrimer containing type IX alpha chains in alpha1(IX)alpha2(IX)alpha3(IX) trimers; type IX collagen triple helices associate to form a structure that links glycosaminoglycans to type II collagen fibrils." [ISBN:0721639976]
is_a: GO:0005593 ! FACIT collagen trimer

[Term]
id: GO:0005595
name: collagen type XII trimer
namespace: cellular_component
def: "A collagen homotrimer of alpha1(XII) chains; type XII collagen triple helices may link sheet-forming or fibrillar collagens to other structures." [ISBN:0721639976]
is_a: GO:0005593 ! FACIT collagen trimer
is_a: GO:0030934 ! anchoring collagen complex

[Term]
id: GO:0005596
name: collagen type XIV trimer
namespace: cellular_component
def: "A collagen homotrimer of alpha1(XIV) chains; type XIV collagen triple helices may link sheet-forming or fibrillar collagens to other structures." [ISBN:0721639976]
is_a: GO:0005593 ! FACIT collagen trimer
is_a: GO:0030934 ! anchoring collagen complex

[Term]
id: GO:0005597
name: collagen type XVI trimer
namespace: cellular_component
def: "A collagen trimer containing alpha(XVI) chains; type XVI trimers can associate with microfibrils." [GOC:mah, PMID:12782140]
is_a: GO:0005593 ! FACIT collagen trimer

[Term]
id: GO:0005598
name: short-chain collagen trimer
namespace: cellular_component
def: "Any collagen trimer that does not form fibrils and that is relatively short compared to the collagen trimers that do form fibrils." [ISBN:0198599587]
is_a: GO:0005581 ! collagen trimer

[Term]
id: GO:0005599
name: collagen type X trimer
namespace: cellular_component
def: "A collagen homotrimer of alpha1(X) chains; type X collagen triple helices form hexagonal networks (sheets)." [ISBN:0721639976, PMID:21421911]
comment: Collagen X trimers have been observed to form hexagonal lattices in vitro, but in vivo they have been found in a fibril associated form (PMID:19693541).
is_a: GO:0005598 ! short-chain collagen trimer
is_a: GO:0030935 ! sheet-forming collagen trimer
relationship: part_of GO:0098646 ! collagen sheet

[Term]
id: GO:0005600
name: collagen type XIII trimer
namespace: cellular_component
def: "A collagen homotrimer of alpha1(XIII) chains; type XIII collagen triple helices span the plasma membrane." [GOC:bm, GOC:dos, ISBN:0721639976]
is_a: GO:0030936 ! transmembrane collagen trimer
relationship: part_of GO:0005887 ! integral component of plasma membrane

[Term]
id: GO:0005601
name: classical-complement-pathway C3/C5 convertase complex
namespace: cellular_component
def: "A heterodimeric protein complex that catalyzes the cleavage of complement components C3 and C5, and acts in the classical pathway of complement activation; consists of one monomer of C2a and one monomer of C4b; C2a is the catalytic subunit, but cannot catalyze cleavage alone." [BRENDA:3.4.21.43, GOC:mah, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/C/Complement.html]
is_a: GO:0043234 ! protein complex
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0005602
name: complement component C1 complex
namespace: cellular_component
def: "A protein complex composed of six subunits of C1q, each formed of the three homologous polypeptide chains C1QA, C1QB, and C1QB, and tetramer of two C1QR and two C1QS polypeptide chains." [GOC:add, ISBN:0781735149]
synonym: "complement component C1q complex" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0005603
name: obsolete complement component C2 complex
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because prior to cleavage, complement component C2 is a single polypeptide rather than a complex, and after cleavage the products do not remain physically associated; there is thus no known biological entity corresponding to "complement C2 complex".
synonym: "complement component C2 complex" EXACT []
is_obsolete: true

[Term]
id: GO:0005604
name: basement membrane
namespace: cellular_component
def: "A thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers." [ISBN:0198547684]
comment: Note that this term has no relationship to 'membrane ; GO:0016020' because the basement membrane is not a lipid bilayer.
xref: Wikipedia:Basement_membrane
is_a: GO:0044420 ! extracellular matrix component
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005578 ! proteinaceous extracellular matrix

[Term]
id: GO:0005605
name: basal lamina
namespace: cellular_component
def: "A thin sheet of proteoglycans and glycoproteins, especially laminin, secreted by cells as an extracellular matrix." [ISBN:0198547684]
synonym: "basement lamina" EXACT []
xref: NIF_Subcellular:sao1397492660
xref: Wikipedia:Basal_lamina
is_a: GO:0044420 ! extracellular matrix component
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005604 ! basement membrane

[Term]
id: GO:0005606
name: laminin-1 complex
namespace: cellular_component
def: "A laminin complex composed of alpha1, beta1 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354]
is_a: GO:0043256 ! laminin complex

[Term]
id: GO:0005607
name: laminin-2 complex
namespace: cellular_component
def: "A laminin complex composed of alpha2, beta1 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354]
is_a: GO:0043256 ! laminin complex

[Term]
id: GO:0005608
name: laminin-3 complex
namespace: cellular_component
def: "A laminin complex composed of alpha1, beta2 and gamma1 polypeptide chains." [MEDLINE:95005761]
is_a: GO:0043256 ! laminin complex

[Term]
id: GO:0005609
name: laminin-4 complex
namespace: cellular_component
def: "A laminin complex composed of alpha2, beta2 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354]
is_a: GO:0043256 ! laminin complex

[Term]
id: GO:0005610
name: laminin-5 complex
namespace: cellular_component
def: "A laminin complex composed of alpha3, beta3 and gamma2 polypeptide chains." [GOC:jl, PMID:10842354]
is_a: GO:0043256 ! laminin complex

[Term]
id: GO:0005611
name: laminin-6 complex
namespace: cellular_component
def: "A laminin complex composed of alpha3, beta1 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354]
is_a: GO:0043256 ! laminin complex

[Term]
id: GO:0005612
name: laminin-7 complex
namespace: cellular_component
def: "A laminin complex composed of alpha3, beta2 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354]
is_a: GO:0043256 ! laminin complex

[Term]
id: GO:0005613
name: obsolete laminin receptor protein
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it is out of date. It seems to be referring to the non-integrin 34/67kDa laminin receptor, which new research has shown to actually be a ribosomal protein of the SP2 family.
synonym: "laminin receptor protein" EXACT []
is_obsolete: true
consider: GO:0008305

[Term]
id: GO:0005614
name: interstitial matrix
namespace: cellular_component
def: "A type of extracellular matrix found in interstitial connective tissue, characterized by the presence of fibronectins, proteoglycans, and types I, III, V, VI, VII and XII collagens." [PMID:8450001]
is_a: GO:0005578 ! proteinaceous extracellular matrix

[Term]
id: GO:0005615
name: extracellular space
namespace: cellular_component
def: "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
comment: Note that for multicellular organisms, the extracellular space refers to everything outside a cell, but still within the organism (excluding the extracellular matrix). Gene products from a multi-cellular organism that are secreted from a cell into the interstitial fluid or blood can therefore be annotated to this term.
subset: goslim_chembl
subset: goslim_generic
subset: goslim_plant
synonym: "intercellular space" RELATED []
xref: NIF_Subcellular:sao1425028079
is_a: GO:0044421 ! extracellular region part

[Term]
id: GO:0005616
name: larval serum protein complex
namespace: cellular_component
def: "A multisubunit protein complex which, in Drosophila, is a heterohexamer of three subunits, alpha, beta and gamma. The complex is thought to store amino acids for synthesis of adult proteins." [GOC:jl, PMID:6781759]
is_a: GO:0043234 ! protein complex
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0005617
name: obsolete larval serum protein-1
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "larval serum protein-1" EXACT []
synonym: "LSP1" EXACT []
is_obsolete: true

[Term]
id: GO:0005618
name: cell wall
namespace: cellular_component
def: "The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins." [GOC:giardia, http://en.wikipedia.org/wiki/Microbial_cyst, ISBN:0198547684, PMID:15134259]
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
xref: Wikipedia:Cell_wall
is_a: GO:0030312 ! external encapsulating structure

[Term]
id: GO:0005619
name: ascospore wall
namespace: cellular_component
def: "The specialized cell wall of the ascospore (spore), which is the product of meiotic division. Examples of this component are found in Fungi." [GOC:vw, ISBN:0879693568]
synonym: "fungal-type spore wall" BROAD [GOC:mah]
is_a: GO:0009277 ! fungal-type cell wall
is_a: GO:0031160 ! spore wall

[Term]
id: GO:0005621
name: cellular bud scar
namespace: cellular_component
def: "Crater-like ring of chitinous scar tissue located on the surface of the mother cell. It is formed after the newly emerged daughter cell separates thereby marking the site of cytokinesis and septation. The number of bud scars that accumulate on the surface of a cell is a useful determinant of replicative age." [GOC:rn, PMID:14600225, PMID:2005820]
is_a: GO:0044426 ! cell wall part
relationship: part_of GO:0009277 ! fungal-type cell wall

[Term]
id: GO:0005622
name: intracellular
namespace: cellular_component
def: "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "internal to cell" EXACT []
synonym: "nucleocytoplasm" RELATED [GOC:mah]
synonym: "protoplasm" EXACT []
synonym: "protoplast" RELATED [GOC:mah]
xref: Wikipedia:Intracellular
is_a: GO:0044464 ! cell part

[Term]
id: GO:0005623
name: cell
namespace: cellular_component
def: "The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:go_curators]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_plant
subset: gosubset_prok
xref: NIF_Subcellular:sao1813327414
xref: Wikipedia:Cell_(biology)
is_a: GO:0005575 ! cellular_component
property_value: IAO:0000589 "cell and encapsulating structures" xsd:string

[Term]
id: GO:0005624
name: obsolete membrane fraction
namespace: cellular_component
def: "OBSOLETE: That fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes." [GOC:ma]
comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component.
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_yeast
subset: gosubset_prok
synonym: "membrane fraction" EXACT []
is_obsolete: true
consider: GO:0016020

[Term]
id: GO:0005625
name: obsolete soluble fraction
namespace: cellular_component
def: "OBSOLETE: That fraction of cells, prepared by disruptive biochemical methods, that is soluble in water." [GOC:ma]
comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component.
synonym: "soluble" BROAD []
synonym: "soluble fraction" EXACT []
is_obsolete: true
consider: GO:0005575

[Term]
id: GO:0005626
name: obsolete insoluble fraction
namespace: cellular_component
def: "OBSOLETE: That fraction of cells, prepared by disruptive biochemical methods, that is not soluble in water." [GOC:ma]
comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component.
subset: gosubset_prok
synonym: "insoluble fraction" EXACT []
synonym: "particle-bound" RELATED []
is_obsolete: true
consider: GO:0005575

[Term]
id: GO:0005627
name: obsolete ascus
namespace: cellular_component
def: "OBSOLETE. A sac-like fruiting body (ascomycete Fungi); contains ascospores (typically eight in number)." [ISBN:0198547684]
comment: This term was made obsolete because it is a structure that contains cell (ascospores) rather than a cellular component. To update annotations, consider the external ontology term 'ascus ; FAO:0000014'.
synonym: "ascus" EXACT []
is_obsolete: true

[Term]
id: GO:0005628
name: prospore membrane
namespace: cellular_component
def: "The prospore membrane is a double-membraned structure that extends from the cytoplasmic face of the spindle pole bodies to encompass the spindle pole bodies and the four nuclear lobes that are formed during meiosis. It helps isolate the meiotic nuclei from the cytoplasm during spore formation and serves as a foundation for the formation of the spore walls. An example of this component is found in Schizosaccharomyces pombe." [ISBN:0879693649]
subset: gosubset_prok
synonym: "ascospore-type prospore membrane" EXACT [GOC:mah]
synonym: "forespore membrane" RELATED []
synonym: "FSM" EXACT []
is_a: GO:0016020 ! membrane
is_a: GO:0044464 ! cell part
relationship: part_of GO:0042764 ! ascospore-type prospore

[Term]
id: GO:0005630
name: dityrosine layer of spore wall
namespace: cellular_component
def: "The outermost layer of the spore wall, as described in Saccharomyces." [ISBN:0879693568]
is_a: GO:0044426 ! cell wall part
relationship: part_of GO:0005619 ! ascospore wall

[Term]
id: GO:0005631
name: chitosan layer of spore wall
namespace: cellular_component
def: "The second outermost layer of the spore wall, as described in Saccharomyces." [ISBN:0879693568]
is_a: GO:0044426 ! cell wall part
relationship: part_of GO:0005619 ! ascospore wall

[Term]
id: GO:0005632
name: inner layer of spore wall
namespace: cellular_component
def: "Either of the two innermost layers of the spore wall, as described in Saccharomyces." [ISBN:0879693568]
is_a: GO:0044426 ! cell wall part
relationship: part_of GO:0005619 ! ascospore wall

[Term]
id: GO:0005633
name: ascus lipid particle
namespace: cellular_component
def: "Any particle of coalesced lipids in an ascus or ascospore. May include associated proteins." [GOC:mah, PMID:12702293]
synonym: "ascus lipid droplet" EXACT [GOC:curators]
is_a: GO:0005811 ! lipid particle

[Term]
id: GO:0005634
name: nucleus
namespace: cellular_component
def: "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
synonym: "cell nucleus" EXACT []
xref: NIF_Subcellular:sao1702920020
xref: Wikipedia:Cell_nucleus
is_a: GO:0043231 ! intracellular membrane-bounded organelle

[Term]
id: GO:0005635
name: nuclear envelope
namespace: cellular_component
alt_id: GO:0005636
def: "The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_plant
xref: Wikipedia:Nuclear_envelope
is_a: GO:0031967 ! organelle envelope
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0012505 ! endomembrane system

[Term]
id: GO:0005637
name: nuclear inner membrane
namespace: cellular_component
def: "The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope." [GOC:ma]
synonym: "inner envelope" BROAD []
synonym: "inner nuclear membrane" EXACT [GOC:kmv, GOC:vw, PMID:21411627]
xref: NIF_Subcellular:sao1612527463
is_a: GO:0019866 ! organelle inner membrane
is_a: GO:0031965 ! nuclear membrane

[Term]
id: GO:0005638
name: lamin filament
namespace: cellular_component
def: "Any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope. They are classified as lamins A, B and C." [ISBN:0198547684]
synonym: "type V intermediate filament" EXACT []
is_a: GO:0005882 ! intermediate filament
is_a: GO:0044428 ! nuclear part
intersection_of: GO:0005882 ! intermediate filament
intersection_of: part_of GO:0005652 ! nuclear lamina
relationship: part_of GO:0005652 ! nuclear lamina

[Term]
id: GO:0005639
name: integral component of nuclear inner membrane
namespace: cellular_component
def: "The component of the nuclear inner membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:go_curators]
synonym: "integral to nuclear inner membrane" NARROW []
is_a: GO:0031229 ! intrinsic component of nuclear inner membrane
is_a: GO:0031301 ! integral component of organelle membrane
intersection_of: GO:0016021 ! integral component of membrane
intersection_of: part_of GO:0005637 ! nuclear inner membrane
relationship: part_of GO:0005637 ! nuclear inner membrane

[Term]
id: GO:0005640
name: nuclear outer membrane
namespace: cellular_component
def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes." [ISBN:0198547684]
synonym: "outer envelope" BROAD []
synonym: "perinuclear membrane" EXACT []
xref: NIF_Subcellular:sao1617136075
is_a: GO:0031965 ! nuclear membrane
is_a: GO:0031968 ! organelle outer membrane
is_a: GO:0044425 ! membrane part
relationship: part_of GO:0042175 ! nuclear outer membrane-endoplasmic reticulum membrane network

[Term]
id: GO:0005641
name: nuclear envelope lumen
namespace: cellular_component
alt_id: GO:0005653
def: "The region between the two lipid bilayers of the nuclear envelope; 20-40 nm wide." [GOC:ai]
comment: Note that this term should not be confused with the cellular component term 'perinuclear region ; GO:0048471'.
synonym: "nuclear intermembrane space" EXACT []
synonym: "nuclear membrane lumen" RELATED []
synonym: "perinuclear space" EXACT []
is_a: GO:0031970 ! organelle envelope lumen
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0005635 ! nuclear envelope

[Term]
id: GO:0005642
name: annulate lamellae
namespace: cellular_component
def: "Stacks of endoplasmic reticulum (ER) membranes containing a high density of nuclear pores, thought to form from excess nuclear membrane components, that have been described in a number of different cells. Annulate lamellar membranes are continuous with and embedded within the ER." [PMID:12631728]
is_a: GO:0044464 ! cell part
is_a: GO:0098589 ! membrane region
relationship: part_of GO:0042175 ! nuclear outer membrane-endoplasmic reticulum membrane network

[Term]
id: GO:0005643
name: nuclear pore
namespace: cellular_component
alt_id: GO:0005644
def: "Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]
subset: goslim_pir
synonym: "NPC" EXACT []
synonym: "nuclear pore complex" EXACT []
synonym: "nuclear pore membrane protein" NARROW []
synonym: "nucleopore" EXACT [GOC:al, PMID:7603572]
xref: NIF_Subcellular:sao220861693
xref: Wikipedia:Nuclear_pore
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0005635 ! nuclear envelope

[Term]
id: GO:0005645
name: obsolete RAN-binding protein
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "RAN-binding protein" EXACT []
is_obsolete: true
replaced_by: GO:0008536
consider: GO:0005634
consider: GO:0005643
consider: GO:0005737

[Term]
id: GO:0005646
name: obsolete importin
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "importin" EXACT []
synonym: "karyopherin" EXACT []
is_obsolete: true
consider: GO:0005487
consider: GO:0005634
consider: GO:0005643
consider: GO:0005737

[Term]
id: GO:0005647
name: obsolete importin, alpha-subunit
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "importin, alpha-subunit" EXACT []
synonym: "karyopherin-alpha" EXACT []
is_obsolete: true
consider: GO:0005487
consider: GO:0005634
consider: GO:0005643
consider: GO:0005737

[Term]
id: GO:0005648
name: obsolete importin, beta-subunit
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "importin, beta-subunit" EXACT []
synonym: "karyopherin-beta1" EXACT []
is_obsolete: true
consider: GO:0005487
consider: GO:0005634
consider: GO:0005643
consider: GO:0005737

[Term]
id: GO:0005649
name: obsolete transportin
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "karyopherin-beta2" EXACT []
synonym: "transportin" EXACT []
is_obsolete: true
consider: GO:0005634
consider: GO:0005643
consider: GO:0005737

[Term]
id: GO:0005650
name: obsolete importin, alpha-subunit transport factor
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "CAS" RELATED []
synonym: "importin, alpha-subunit transport factor" EXACT []
is_obsolete: true
consider: GO:0005634
consider: GO:0005643
consider: GO:0005737

[Term]
id: GO:0005651
name: obsolete exportin
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "exportin" EXACT []
is_obsolete: true
consider: GO:0005487
consider: GO:0005634
consider: GO:0005643
consider: GO:0005737

[Term]
id: GO:0005652
name: nuclear lamina
namespace: cellular_component
def: "The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a cell nucleus, composed of lamin filaments. The polypeptides of the lamina are thought to be concerned in the dissolution of the nuclear envelope and its re-formation during mitosis. The lamina is composed of lamin A and lamin C filaments cross-linked into an orthogonal lattice, which is attached via lamin B to the inner nuclear membrane through interactions with a lamin B receptor, an IFAP, in the membrane." [ISBN:0198506732, ISBN:0716731363]
xref: NIF_Subcellular:sao1455996588
xref: Wikipedia:Nuclear_lamina
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0034399 ! nuclear periphery

[Term]
id: GO:0005654
name: nucleoplasm
namespace: cellular_component
def: "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_plant
xref: NIF_Subcellular:sao661522542
xref: Wikipedia:Nucleoplasm
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0031981 ! nuclear lumen

[Term]
id: GO:0005655
name: nucleolar ribonuclease P complex
namespace: cellular_component
def: "A ribonuclease P complex located in the nucleolus of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. Eukaryotic nucleolar ribonuclease P complexes generally contain a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules." [GOC:mah, PMID:12045094]
synonym: "nucleolar RNase P complex" EXACT []
is_a: GO:0030681 ! multimeric ribonuclease P complex
is_a: GO:0044452 ! nucleolar part
intersection_of: GO:0030677 ! ribonuclease P complex
intersection_of: part_of GO:0005730 ! nucleolus
relationship: part_of GO:0005730 ! nucleolus

[Term]
id: GO:0005656
name: nuclear pre-replicative complex
namespace: cellular_component
def: "A protein-DNA complex assembled at eukaryotic DNA replication origins during late mitosis and G1, allowing the origin to become competent, or 'licensed', for replication. The complex normally includes the origin recognition complex (ORC), Cdc6, Cdt1 and the MiniChromosome Maintenance (Mcm2-7) proteins." [PMID:15222894]
synonym: "eukaryotic pre-replicative complex" EXACT [GOC:bf, GOC:bhm, GOC:jh2]
synonym: "pre-RC" RELATED []
synonym: "pre-replicative complex" BROAD [GOC:bf, GOC:bhm, GOC:jh2]
is_a: GO:0036387 ! pre-replicative complex
is_a: GO:0044451 ! nucleoplasm part
relationship: has_part GO:0000808 ! origin recognition complex
relationship: has_part GO:0042555 ! MCM complex

[Term]
id: GO:0005657
name: replication fork
namespace: cellular_component
def: "The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:mah, ISBN:0198547684]
subset: gosubset_prok
synonym: "replication focus" RELATED []
xref: Wikipedia:Replication_fork
is_a: GO:0044427 ! chromosomal part

[Term]
id: GO:0005658
name: alpha DNA polymerase:primase complex
namespace: cellular_component
def: "A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which catalyzes the synthesis of an RNA primer on the lagging strand of replicating DNA; the smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis." [GOC:mah, PMID:11395402]
synonym: "DNA polymerase alpha:primase complex" EXACT []
synonym: "heterotetrameric polymerase alpha holoenzyme" EXACT []
synonym: "pol-prim" RELATED []
synonym: "primosome" BROAD []
is_a: GO:0044454 ! nuclear chromosome part
is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex
relationship: part_of GO:0043601 ! nuclear replisome

[Term]
id: GO:0005660
name: obsolete delta-DNA polymerase cofactor complex
namespace: cellular_component
def: "OBSOLETE. A complex of proteins that interacts with delta-DNA polymerase, promoting elongation. In humans it is a heteropentamer of subunits of 140/145, 40, 38, 37 and 36.5 kDa, which form a complex with the proliferating cell nuclear antigen (PCNA) in the presence of ATP." [GOC:jl]
comment: This term was made obsolete because it refers to two distinct complexes, PCNA and Replication factor C (RFC), the latter of which is already represented as a separate, unrelated GO term (DNA replication factor C complex ; GO:0005663). In addition, the phrase 'delta-DNA polymerase cofactor' to represent both PCNA and RFC is not used in current literature.
synonym: "delta DNA polymerase cofactor complex" EXACT []
synonym: "delta-DNA polymerase cofactor complex" EXACT []
is_obsolete: true
consider: GO:0005663
consider: GO:0043626

[Term]
id: GO:0005662
name: DNA replication factor A complex
namespace: cellular_component
def: "A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa." [PMID:9242902]
synonym: "replication protein A" EXACT []
synonym: "RPA" EXACT []
xref: Wikipedia:Replication_protein_A
is_a: GO:0043234 ! protein complex
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0043601 ! nuclear replisome

[Term]
id: GO:0005663
name: DNA replication factor C complex
namespace: cellular_component
def: "A complex that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. In eukaryotes the complex consists of five polypeptides." [PMID:14614842, PMID:14646196, PMID:16172520]
subset: goslim_pir
subset: gosubset_prok
synonym: "activator 1 complex" EXACT []
synonym: "RFC complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0005657 ! replication fork

[Term]
id: GO:0005664
name: nuclear origin of replication recognition complex
namespace: cellular_component
def: "A multisubunit complex that is located at the replication origins of a chromosome in the nucleus." [GOC:elh]
synonym: "eukaryotic ORC" EXACT []
synonym: "nuclear ORC" EXACT []
is_a: GO:0000808 ! origin recognition complex
is_a: GO:0044454 ! nuclear chromosome part

[Term]
id: GO:0005665
name: DNA-directed RNA polymerase II, core complex
namespace: cellular_component
def: "RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]
synonym: "RNA polymerase II complex" BROAD []
synonym: "RNAP II complex" BROAD []
is_a: GO:0044451 ! nucleoplasm part
is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex
intersection_of: GO:0000428 ! DNA-directed RNA polymerase complex
intersection_of: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme
relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme

[Term]
id: GO:0005666
name: DNA-directed RNA polymerase III complex
namespace: cellular_component
def: "RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]
synonym: "DNA-directed RNA polymerase III activity" RELATED []
is_a: GO:0044451 ! nucleoplasm part
is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex

[Term]
id: GO:0005667
name: transcription factor complex
namespace: cellular_component
def: "A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl]
subset: goslim_metagenomics
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0005668
name: RNA polymerase transcription factor SL1 complex
namespace: cellular_component
def: "A RNA polymerase I-specific transcription factor complex that contains the TATA-box-binding protein (TBP) and at least three TBP-associated factors including proteins known in mammals as TAFI110, TAFI63 and TAFI48." [PMID:15691654]
synonym: "selectivity factor SL1 complex" EXACT [GOC:mah]
synonym: "TIF-IB" EXACT [CORUM:480, PMID:15691654]
is_a: GO:0000120 ! RNA polymerase I transcription factor complex

[Term]
id: GO:0005669
name: transcription factor TFIID complex
namespace: cellular_component
def: "A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters." [GOC:krc, GOC:mah, ISBN:0471953393, ISBN:0879695501]
is_a: GO:0044451 ! nucleoplasm part
is_a: GO:0090575 ! RNA polymerase II transcription factor complex
relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme

[Term]
id: GO:0005670
name: obsolete transcription-activating factor, 30kD
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "transcription-activating factor, 30kD" EXACT []
is_obsolete: true
replaced_by: GO:0005669

[Term]
id: GO:0005671
name: Ada2/Gcn5/Ada3 transcription activator complex
namespace: cellular_component
alt_id: GO:0002928
def: "A multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. Contains either GCN5 or PCAF in a mutually exclusive manner. The budding yeast complex includes Gcn5p, two proteins of the Ada family, and two TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins. Both ATAC- or SAGA (see GO:0000124, SAGA complex) are involved in the acetylation of histone H3K9 and K14 residues." [PMID:10637607]
comment: In human, this complex is composed of GCN5 or PCAF, ADA2a, ADA3, ZZZ3, ATAC2, SGF29, HCF1, WDR5,YEATS2, NC2-beta, and MBIP.
synonym: "Ada Two-A containing complex" EXACT [GOC:rl, PMID:18838386]
synonym: "Ada-Two-A-containing complex" EXACT []
synonym: "ATAC complex" EXACT [GOC:rl, PMID:18838386]
is_a: GO:0000123 ! histone acetyltransferase complex

[Term]
id: GO:0005672
name: transcription factor TFIIA complex
namespace: cellular_component
def: "A component of the transcription machinery of RNA Polymerase II. In humans, TFIIA is a heterotrimer composed of an alpha (P35), beta (P19) and gamma subunits (P12)." [GOC:jl, PMID:17560669]
is_a: GO:0044451 ! nucleoplasm part
is_a: GO:0090575 ! RNA polymerase II transcription factor complex
relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme

[Term]
id: GO:0005673
name: transcription factor TFIIE complex
namespace: cellular_component
def: "A transcription factor which in humans consists of a complex of two alpha and two beta chains. Recruits TFIIH to the initiation complex and helps activate both RNA polymerase II and TFIIH." [GOC:jl, PMID:16547462]
is_a: GO:0044451 ! nucleoplasm part
is_a: GO:0090575 ! RNA polymerase II transcription factor complex
relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme

[Term]
id: GO:0005674
name: transcription factor TFIIF complex
namespace: cellular_component
def: "A general transcription initiation factor which in humans consists of a heterodimer of an alpha and a beta subunit. Helps recruit RNA polymerase II to the initiation complex and promotes translation elongation." [GOC:jl, PMID:7597077]
is_a: GO:0044451 ! nucleoplasm part
is_a: GO:0090575 ! RNA polymerase II transcription factor complex
relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme

[Term]
id: GO:0005675
name: holo TFIIH complex
namespace: cellular_component
def: "A complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. It is composed of  the core TFIIH complex and the TFIIK complex." [GOC:ew, GOC:krc, PMID:14500720, PMID:22308316, PMID:22572993, PMID:7813015]
is_a: GO:0032806 ! carboxy-terminal domain protein kinase complex
is_a: GO:0044451 ! nucleoplasm part
is_a: GO:0090575 ! RNA polymerase II transcription factor complex
relationship: has_part GO:0000439 ! core TFIIH complex
relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme

[Term]
id: GO:0005677
name: chromatin silencing complex
namespace: cellular_component
def: "Any protein complex that mediates changes in chromatin structure that result in transcriptional silencing." [GOC:mah]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0005678
name: obsolete chromatin assembly complex
namespace: cellular_component
def: "OBSOLETE: Any protein complex that acts in the formation of nucleosomes or higher order chromatin structure." [GOC:mah]
comment: This term was made obsolete because its definition no longer reflects and cannot be modified to be consistent with the current state of knowledge.
synonym: "chromatin assembly complex" EXACT []
synonym: "nucleosome assembly complex" NARROW []
is_obsolete: true
consider: GO:0031497

[Term]
id: GO:0005680
name: anaphase-promoting complex
namespace: cellular_component
def: "A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B." [GOC:jh, GOC:vw, PMID:10465783, PMID:10611969]
comment: Note that the synonym 'APC' should not be confused with the abbreviation for the adenomatous polyposis coli gene and protein.
synonym: "anaphase promoting complex" EXACT []
synonym: "APC" BROAD []
synonym: "cyclosome" EXACT []
xref: Wikipedia:Anaphase-promoting_complex
is_a: GO:0000152 ! nuclear ubiquitin ligase complex
is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex

[Term]
id: GO:0005681
name: spliceosomal complex
namespace: cellular_component
def: "Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]
subset: goslim_pir
synonym: "spliceosome" BROAD []
synonym: "spliceosome complex" EXACT []
xref: Wikipedia:Spliceosome
is_a: GO:0030529 ! intracellular ribonucleoprotein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0005682
name: U5 snRNP
namespace: cellular_component
def: "A ribonucleoprotein complex that contains small nuclear RNA U5." [GOC:krc, GOC:mah]
synonym: "snRNP U5" EXACT [GOC:mah]
is_a: GO:0097525 ! spliceosomal snRNP complex

[Term]
id: GO:0005683
name: U7 snRNP
namespace: cellular_component
def: "A ribonucleoprotein complex that contains the U7 snRNA and is required for the 3'-end processing of replication-dependent histone pre-mRNAs." [PMID:12872004]
synonym: "snRNP U7" EXACT [GOC:mah]
is_a: GO:0030532 ! small nuclear ribonucleoprotein complex

[Term]
id: GO:0005684
name: U2-type spliceosomal complex
namespace: cellular_component
def: "Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron that has canonical consensus sequences near the 5' and 3' ends." [GOC:krc, GOC:mah, PMID:11343900]
comment: A U2-type complex refers to any of the snRNP-based complexes that form during splicing that uses U2 (as opposed to U12). There are complexes that form during U2-splicing that don't necessarily contain the U2 snRNP.
synonym: "GT-AG spliceosome" NARROW [GOC:krc, GOC:mah]
synonym: "major (U2-type) spliceosomal complex" EXACT [GOC:krc, GOC:mah]
synonym: "major spliceosomal complex" EXACT [GOC:krc, GOC:mah]
is_a: GO:0005681 ! spliceosomal complex

[Term]
id: GO:0005685
name: U1 snRNP
namespace: cellular_component
def: "A ribonucleoprotein complex that contains small nuclear RNA U1." [GOC:krc, GOC:mah]
synonym: "snRNP U1" EXACT [GOC:mah]
is_a: GO:0097525 ! spliceosomal snRNP complex

[Term]
id: GO:0005686
name: U2 snRNP
namespace: cellular_component
def: "A ribonucleoprotein complex that contains small nuclear RNA U2." [GOC:krc, GOC:mah]
comment: U2 snRNP refers to the U2 small nuclear RNA and the proteins that associate with it. U2 snRNP is not considered to be a type of spliceosomal complex by itself.
synonym: "17S U2 snRNP" NARROW []
synonym: "snRNP U2" EXACT [GOC:mah]
is_a: GO:0097525 ! spliceosomal snRNP complex

[Term]
id: GO:0005687
name: U4 snRNP
namespace: cellular_component
def: "A ribonucleoprotein complex that contains small nuclear RNA U4." [GOC:krc, GOC:mah]
synonym: "snRNP U4" EXACT [GOC:mah]
is_a: GO:0097525 ! spliceosomal snRNP complex

[Term]
id: GO:0005688
name: U6 snRNP
namespace: cellular_component
def: "A ribonucleoprotein complex that contains small nuclear RNA U6." [GOC:krc, GOC:mah]
synonym: "snRNP U6" EXACT [GOC:mah]
is_a: GO:0097525 ! spliceosomal snRNP complex

[Term]
id: GO:0005689
name: U12-type spliceosomal complex
namespace: cellular_component
def: "Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron; the series of U12-type spliceosomal complexes is involved in the splicing of the majority of introns that contain atypical AT-AC terminal dinucleotides, as well as other non-canonical introns. The entire splice site signal, not just the terminal dinucleotides, is involved in determining which spliceosome utilizes the site." [GOC:krc, GOC:mah, PMID:11574683, PMID:11971955]
synonym: "AT-AC spliceosomal complex" NARROW [GOC:krc, GOC:mah]
synonym: "minor (U12-type) spliceosomal complex" EXACT [GOC:mah]
synonym: "minor spliceosomal complex" EXACT [GOC:krc, GOC:mah]
xref: Wikipedia:Minor_spliceosome
is_a: GO:0005681 ! spliceosomal complex

[Term]
id: GO:0005690
name: U4atac snRNP
namespace: cellular_component
def: "A ribonucleoprotein complex that contains small nuclear RNA U4atac." [GOC:krc, GOC:mah]
synonym: "snRNP U4atac" EXACT [GOC:mah]
is_a: GO:0097525 ! spliceosomal snRNP complex

[Term]
id: GO:0005691
name: U6atac snRNP
namespace: cellular_component
def: "A ribonucleoprotein complex that contains small nuclear RNA U6atac." [GOC:krc, GOC:mah]
synonym: "snRNP U6atac" EXACT [GOC:mah]
is_a: GO:0097525 ! spliceosomal snRNP complex

[Term]
id: GO:0005692
name: U11 snRNP
namespace: cellular_component
def: "A ribonucleoprotein complex that contains small nuclear RNA U11." [GOC:krc, GOC:mah]
synonym: "12S U11 snRNP" NARROW []
synonym: "snRNP U11" EXACT [GOC:mah]
is_a: GO:0097525 ! spliceosomal snRNP complex

[Term]
id: GO:0005693
name: U12 snRNP
namespace: cellular_component
def: "A ribonucleoprotein complex that contains small nuclear RNA U12." [GOC:krc, GOC:mah]
synonym: "snRNP U12" EXACT [GOC:mah]
is_a: GO:0097525 ! spliceosomal snRNP complex

[Term]
id: GO:0005694
name: chromosome
namespace: cellular_component
def: "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]
comment: Chromosomes include parts that are not part of the chromatin.  Examples include the kinetochore.
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
synonym: "chromatid" RELATED []
synonym: "interphase chromosome" NARROW []
synonym: "prophase chromosome" NARROW []
xref: Wikipedia:Chromosome
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle

[Term]
id: GO:0005695
name: obsolete chromatid
namespace: cellular_component
def: "OBSOLETE. One of the two daughter strands of a duplicated chromosome that become apparent between early prophase and metaphase in mitosis and between diplotene and second metaphase in meiosis." [ISBN:0198506732]
comment: This term was made obsolete because it is not a unique subcellular component, i.e. the difference between this term and 'chromosome' is based on temporal and process distinctions.
synonym: "chromatid" EXACT []
is_obsolete: true
consider: GO:0000793
consider: GO:0000794
consider: GO:0005694

[Term]
id: GO:0005696
name: obsolete telomere
namespace: cellular_component
def: "OBSOLETE. A complex of DNA and protein that seals the end of a chromosome. The telomeric DNA consists of simple tandemly repeated sequences specific for each species. Typically one strand is G-rich and the other C-rich. The G-rich strand forms a 3'-terminal overhang, the length of which varies with species. The single strand overhang is bound by a variety of proteins, including telomere capping proteins that bind to the single-stranded DNA." [ISBN:0198506732, PMID:11352055]
comment: This term was made obsolete because the definition was too sequence oriented and too restrictive.
synonym: "telomere" EXACT []
is_obsolete: true
consider: GO:0000781
consider: GO:0000782

[Term]
id: GO:0005697
name: telomerase holoenzyme complex
namespace: cellular_component
def: "Telomerase is a ribonucleoprotein enzyme complex, with a minimal catalytic core composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. In vivo, the holoenzyme complex often contains additional subunits." [PMID:11884619]
subset: goslim_pir
is_a: GO:0030529 ! intracellular ribonucleoprotein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0005698
name: obsolete centromere
namespace: cellular_component
def: "OBSOLETE. The region of a eukaryotic chromosome that is attached to the spindle during nuclear division. It is defined genetically as the region of the chromosome that always segregates at the first division of meiosis; the region of the chromosome in which no crossing over occurs. At the start of M phase, each chromosome consists of two sister chromatids with a constriction at a point which forms the centromere. During late prophase two kinetochores assemble on each centromere, one kinetochore on each sister chromatid." [ISBN:0198506732]
comment: This term was made obsolete because it is a genetically defined region and not a specific subcellular localization.
synonym: "centromere" EXACT []
is_obsolete: true
consider: GO:0000775

[Term]
id: GO:0005700
name: polytene chromosome
namespace: cellular_component
def: "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
xref: Wikipedia:Polytene_chromosome
is_a: GO:0005694 ! chromosome

[Term]
id: GO:0005701
name: polytene chromosome chromocenter
namespace: cellular_component
def: "A region at which the centric regions of polytene chromosomes are joined together." [GOC:bf, ISBN:0120649012]
synonym: "polytene chromosome chromocentre" EXACT []
is_a: GO:0010369 ! chromocenter
intersection_of: GO:0010369 ! chromocenter
intersection_of: part_of GO:0005700 ! polytene chromosome
relationship: part_of GO:0005700 ! polytene chromosome

[Term]
id: GO:0005702
name: polytene chromosome weak point
namespace: cellular_component
def: "A region of the polytene chromosome where the diameter is considerably decreased, probably resulting from local differences in chromosome organization." [GOC:bf, ISBN:0120649012]
synonym: "constriction" BROAD []
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0005700 ! polytene chromosome

[Term]
id: GO:0005703
name: polytene chromosome puff
namespace: cellular_component
def: "A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription." [GOC:bf, ISBN:0120649012]
is_a: GO:0098687 ! chromosomal region
relationship: part_of GO:0005700 ! polytene chromosome

[Term]
id: GO:0005704
name: polytene chromosome band
namespace: cellular_component
def: "A stretch of densely packed chromatin along the polytene chromosome, visible as a morphologically distinct band." [GOC:bf, PMID:11361342]
is_a: GO:0098687 ! chromosomal region
relationship: part_of GO:0005700 ! polytene chromosome

[Term]
id: GO:0005705
name: polytene chromosome interband
namespace: cellular_component
def: "A stretch of less tightly packed chromatin along the polytene chromosome, found between bands." [GOC:bf, PMID:11361342]
is_a: GO:0098687 ! chromosomal region
relationship: part_of GO:0005700 ! polytene chromosome

[Term]
id: GO:0005706
name: polytene chromosome ectopic fiber
namespace: cellular_component
def: "A thread-like connection joining two regions of ectopically paired polytene chromosomes." [GOC:bf, ISBN:0120649012]
synonym: "polytene chromosome ectopic fibre" EXACT []
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0005700 ! polytene chromosome

[Term]
id: GO:0005707
name: obsolete interphase chromosome
namespace: cellular_component
def: "OBSOLETE. A chromosome found in the cell during interphase of the cell cycle. Chromosomes are usually decondensed during interphase and each long DNA molecule in a chromosome is divided into a large number of discrete domains that are folded differently." [GOC:ai, ISBN:0815316194]
comment: This term was made obsolete because it is based on a temporal division of the cell cycle.
synonym: "interphase chromosome" EXACT []
is_obsolete: true
consider: GO:0005694

[Term]
id: GO:0005708
name: obsolete mitotic chromosome
namespace: cellular_component
def: "OBSOLETE. A chromosome involved in the process of mitosis." [GOC:ai]
comment: This term was made obsolete because it is based on a process.
synonym: "mitotic chromosome" EXACT []
is_obsolete: true
consider: GO:0000793
consider: GO:0000794

[Term]
id: GO:0005709
name: obsolete prophase chromosome
namespace: cellular_component
def: "OBSOLETE. A chromosome found in the cell during prophase." [GOC:ai]
comment: This term was made obsolete because it is based on a temporal division of the cell cycle.
synonym: "prophase chromosome" EXACT []
is_obsolete: true
consider: GO:0005694

[Term]
id: GO:0005710
name: obsolete metaphase chromosome
namespace: cellular_component
def: "OBSOLETE. A chromosome found in the cell during metaphase. Typically, sister chromatids are held together at their centromeres and chromosomes are covered with a large number of molecules, including ribonucleoproteins." [GOC:ai]
comment: This term was made obsolete because it is based on a temporal division of the cell cycle.
synonym: "metaphase chromosome" EXACT []
is_obsolete: true
consider: GO:0000793
consider: GO:0000794

[Term]
id: GO:0005711
name: obsolete meiotic chromosome
namespace: cellular_component
def: "OBSOLETE. A chromosome involved in the process of meiosis." [GOC:ai]
comment: This term was made obsolete because it is based on a process.
synonym: "meiotic chromosome" EXACT []
is_obsolete: true
consider: GO:0000794

[Term]
id: GO:0005712
name: chiasma
namespace: cellular_component
def: "A connection formed between chromatids, visible during meiosis, thought to be the point of the interchange involved in crossing-over." [ISBN:0198506732]
xref: Wikipedia:Chiasma_(genetics)
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000794 ! condensed nuclear chromosome

[Term]
id: GO:0005713
name: recombination nodule
namespace: cellular_component
def: "An electron dense structure that is associated with meiotic chromosomes." [GOC:elh]
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000794 ! condensed nuclear chromosome

[Term]
id: GO:0005714
name: early recombination nodule
namespace: cellular_component
def: "An electron dense structure that is associated with meiotic chromosomes in leptotene or zygotene during meiosis I." [GOC:elh]
is_a: GO:0005713 ! recombination nodule

[Term]
id: GO:0005715
name: late recombination nodule
namespace: cellular_component
def: "An electron dense structure that is associated with meiotic chromosomes in pachytene during meiosis I." [GOC:elh]
is_a: GO:0005713 ! recombination nodule

[Term]
id: GO:0005719
name: nuclear euchromatin
namespace: cellular_component
def: "The dispersed less dense form of chromatin in the interphase nucleus. It exists in at least two forms, a some being in the form of transcriptionally active chromatin which is the least condensed, while the rest is inactive euchromatin which is more condensed than active chromatin but less condensed than heterochromatin." [ISBN:0198506732]
is_a: GO:0000790 ! nuclear chromatin
is_a: GO:0000791 ! euchromatin
intersection_of: GO:0000791 ! euchromatin
intersection_of: part_of GO:0000228 ! nuclear chromosome
relationship: part_of GO:0000228 ! nuclear chromosome

[Term]
id: GO:0005720
name: nuclear heterochromatin
namespace: cellular_component
def: "A condensed form of chromatin, occurring in the nucleus during interphase, that stains strongly with basophilic dyes. The DNA of heterochromatin is typically replicated at a later stage in the cell-division cycle than euchromatin." [ISBN:0198506732]
is_a: GO:0000790 ! nuclear chromatin
is_a: GO:0000792 ! heterochromatin
intersection_of: GO:0000792 ! heterochromatin
intersection_of: part_of GO:0000228 ! nuclear chromosome
relationship: part_of GO:0000228 ! nuclear chromosome

[Term]
id: GO:0005721
name: pericentric heterochromatin
namespace: cellular_component
def: "Heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3." [PMID:12019236, PMID:20206496, PMID:22729156]
synonym: "centric heterochromatin" EXACT []
synonym: "centromeric heterochromatin" EXACT [GOC:dph]
is_a: GO:0000792 ! heterochromatin
intersection_of: GO:0000792 ! heterochromatin
intersection_of: part_of GO:0000775 ! chromosome, centromeric region
relationship: part_of GO:0000775 ! chromosome, centromeric region

[Term]
id: GO:0005722
name: beta-heterochromatin
namespace: cellular_component
def: "A diffusely banded region of heterochromatin located between euchromatin and alpha-heterochromatin in the polytene chromosome chromocenter; normally replicated during polytenization." [PMID:11404334, PMID:8878678]
is_a: GO:0005721 ! pericentric heterochromatin
relationship: part_of GO:0005701 ! polytene chromosome chromocenter

[Term]
id: GO:0005723
name: alpha-heterochromatin
namespace: cellular_component
def: "A small, compact region of heterochromatin located in the middle of the polytene chromosome chromocenter, which undergoes little or no replication during polytenization." [PMID:8878678]
is_a: GO:0005721 ! pericentric heterochromatin
relationship: part_of GO:0005701 ! polytene chromosome chromocenter

[Term]
id: GO:0005724
name: nuclear telomeric heterochromatin
namespace: cellular_component
def: "Heterochromatic regions of the chromosome found at the telomeres of a chromosome in the nucleus." [GOC:ai]
is_a: GO:0005720 ! nuclear heterochromatin
is_a: GO:0031933 ! telomeric heterochromatin
intersection_of: GO:0031933 ! telomeric heterochromatin
intersection_of: part_of GO:0000228 ! nuclear chromosome
relationship: part_of GO:0000228 ! nuclear chromosome
relationship: part_of GO:0000784 ! nuclear chromosome, telomeric region

[Term]
id: GO:0005725
name: intercalary heterochromatin
namespace: cellular_component
def: "Any of the regions of heterochromatin that form a reproducible set of dense bands scattered along the euchromatic arms in polytene chromosomes." [PMID:14579245]
is_a: GO:0005720 ! nuclear heterochromatin

[Term]
id: GO:0005726
name: perichromatin fibrils
namespace: cellular_component
def: "Structures of variable diameter visible in the nucleoplasm by electron microscopy, mainly observed near the border of condensed chromatin. The fibrils are enriched in RNA, and are believed to be sites of pre-mRNA splicing and polyadenylylation representing the in situ form of nascent transcripts." [PMID:14731598]
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000790 ! nuclear chromatin

[Term]
id: GO:0005727
name: extrachromosomal circular DNA
namespace: cellular_component
def: "Circular DNA structures that are not part of a chromosome." [GOC:ai]
subset: goslim_metagenomics
subset: gosubset_prok
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0046821 ! extrachromosomal DNA

[Term]
id: GO:0005728
name: extrachromosomal rDNA circle
namespace: cellular_component
def: "Circular DNA molecules encoding ribosomal RNA that are replicated independently of chromosomal replication. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats." [GOC:mah, PMID:12044934]
synonym: "extrachromosomal ribosomal DNA circle" EXACT []
is_a: GO:0005727 ! extrachromosomal circular DNA

[Term]
id: GO:0005729
name: 2-micrometer circle DNA
namespace: cellular_component
def: "A plasmid commonly found in Saccharomyces, inherited in a non-Mendelian manner and often present in 100-400 copies." [PMID:12073320]
is_a: GO:0005727 ! extrachromosomal circular DNA

[Term]
id: GO:0005730
name: nucleolus
namespace: cellular_component
def: "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
xref: NIF_Subcellular:sao1820400233
xref: Wikipedia:Nucleolus
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0031981 ! nuclear lumen

[Term]
id: GO:0005731
name: nucleolus organizer region
namespace: cellular_component
def: "A region of a chromosome where nucleoli form during interphase, and where genes encoding the largest rRNA precursor transcript are tandemly arrayed." [PMID:14504406]
synonym: "NOR" EXACT []
synonym: "nucleolus organiser region" EXACT []
synonym: "nucleolus organizer complex" RELATED []
xref: Wikipedia:Nucleolus_organizer_region
is_a: GO:0030874 ! nucleolar chromatin
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0005732
name: small nucleolar ribonucleoprotein complex
namespace: cellular_component
def: "A ribonucleoprotein complex that contains an RNA molecule of the small nucleolar RNA (snoRNA) family and associated proteins. Most are involved in a step of processing of rRNA: cleavage, 2'-O-methylation, or pseudouridylation. The majority, though not all, fall into one of two classes, box C/D type or box H/ACA type." [GOC:krc, GOC:mah, ISBN:0879695897]
comment: Note that 'nucleolar' in the term name is part of the RNA family designation 'small nucleolar', and does not necessarily reflect the location of the complex.
subset: goslim_pir
synonym: "small nucleolar ribonucleoprotein" EXACT []
synonym: "snoRNP" EXACT []
is_a: GO:0030529 ! intracellular ribonucleoprotein complex

[Term]
id: GO:0005733
name: obsolete small nucleolar RNA
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "small nucleolar RNA" EXACT []
synonym: "snoRNA" EXACT []
is_obsolete: true

[Term]
id: GO:0005734
name: obsolete box C + D snoRNP protein
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "box C + D snoRNP protein" EXACT []
is_obsolete: true

[Term]
id: GO:0005735
name: obsolete box H + ACA snoRNP protein
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "box H + ACA snoRNP protein" EXACT []
is_obsolete: true

[Term]
id: GO:0005736
name: DNA-directed RNA polymerase I complex
namespace: cellular_component
def: "RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]
synonym: "DNA-directed RNA polymerase I activity" RELATED []
is_a: GO:0044452 ! nucleolar part
is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex

[Term]
id: GO:0005737
name: cytoplasm
namespace: cellular_component
def: "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
xref: Wikipedia:Cytoplasm
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0005739
name: mitochondrion
namespace: cellular_component
def: "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
comment: Some anaerobic or microaerophilic organisms (e.g. Entamoeba histolytica, Giardia intestinalis and several Microsporidia species) do not have mitochondria, and contain mitochondrion-related organelles (MROs) instead, called mitosomes or hydrogenosomes, very likely derived from mitochondria. To annotate gene products located in these mitochondrial relics in species such as Entamoeba histolytica, Giardia intestinalis or others, please use GO:0032047 'mitosome' or GO:0042566 'hydrogenosome'. (See PMID:24316280 for a list of species currently known to contain mitochondrion-related organelles.)
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
synonym: "mitochondria" EXACT []
xref: NIF_Subcellular:sao1860313010
xref: Wikipedia:Mitochondrion
is_a: GO:0043231 ! intracellular membrane-bounded organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005740
name: mitochondrial envelope
namespace: cellular_component
def: "The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space." [GOC:ai, GOC:pz]
subset: goslim_candida
subset: goslim_yeast
is_a: GO:0031967 ! organelle envelope
is_a: GO:0044429 ! mitochondrial part

[Term]
id: GO:0005741
name: mitochondrial outer membrane
namespace: cellular_component
def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai]
synonym: "outer mitochondrial membrane" EXACT []
xref: NIF_Subcellular:sao1289741256
xref: Wikipedia:Outer_mitochondrial_membrane
is_a: GO:0031966 ! mitochondrial membrane
is_a: GO:0031968 ! organelle outer membrane

[Term]
id: GO:0005742
name: mitochondrial outer membrane translocase complex
namespace: cellular_component
def: "A large complex of the mitochondrial outer membrane that mediates transport of proteins into all mitochondrial compartments." [PMID:12581629]
synonym: "GIP complex" NARROW []
synonym: "TOM complex" NARROW []
is_a: GO:0098799 ! outer mitochondrial membrane protein complex
relationship: part_of GO:0005741 ! mitochondrial outer membrane

[Term]
id: GO:0005743
name: mitochondrial inner membrane
namespace: cellular_component
def: "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]
synonym: "inner mitochondrial membrane" EXACT []
xref: NIF_Subcellular:sao1371347282
xref: Wikipedia:Inner_mitochondrial_membrane
is_a: GO:0019866 ! organelle inner membrane
is_a: GO:0031966 ! mitochondrial membrane

[Term]
id: GO:0005744
name: mitochondrial inner membrane presequence translocase complex
namespace: cellular_component
def: "The protein transport machinery of the mitochondrial inner membrane that contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor." [EC:3.6.3.51, PMID:8851659]
comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'.
subset: goslim_pir
synonym: "mitochondrial inner membrane pre-sequence translocase complex" EXACT []
synonym: "mitochondrial inner membrane translocase complex" EXACT []
synonym: "Tim23 complex" NARROW []
is_a: GO:0098800 ! inner mitochondrial membrane protein complex
relationship: part_of GO:0005743 ! mitochondrial inner membrane

[Term]
id: GO:0005745
name: m-AAA complex
namespace: cellular_component
def: "Protease complex of the mitochondrial inner membrane that is involved in mitochondrial protein turnover and in processing of proteins imported into mitochondria." [GOC:mcc, PMID:12417197, PMID:21147776]
is_a: GO:0098800 ! inner mitochondrial membrane protein complex
relationship: part_of GO:0031305 ! integral component of mitochondrial inner membrane

[Term]
id: GO:0005746
name: mitochondrial respiratory chain
namespace: cellular_component
def: "The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:curators, GOC:ecd, ISBN:0198547684]
synonym: "mitochondrial electron transport chain" EXACT []
is_a: GO:0044455 ! mitochondrial membrane part
is_a: GO:0070469 ! respiratory chain
intersection_of: GO:0070469 ! respiratory chain
intersection_of: part_of GO:0005743 ! mitochondrial inner membrane
relationship: part_of GO:0005743 ! mitochondrial inner membrane

[Term]
id: GO:0005747
name: mitochondrial respiratory chain complex I
namespace: cellular_component
alt_id: GO:0005748
def: "A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684]
is_a: GO:0045271 ! respiratory chain complex I
is_a: GO:0098800 ! inner mitochondrial membrane protein complex
intersection_of: GO:0045271 ! respiratory chain complex I
intersection_of: part_of GO:0005739 ! mitochondrion
relationship: part_of GO:0005739 ! mitochondrion
relationship: part_of GO:0005746 ! mitochondrial respiratory chain

[Term]
id: GO:0005749
name: mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)
namespace: cellular_component
alt_id: GO:0008136
alt_id: GO:0009362
alt_id: GO:0019738
alt_id: GO:0030390
def: "A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain." [GOC:mtg_sensu, GOC:vw, ISBN:0198547684]
synonym: "mitochondrial fumarate reductase complex" EXACT []
is_a: GO:0045257 ! succinate dehydrogenase complex (ubiquinone)
is_a: GO:0045283 ! fumarate reductase complex
is_a: GO:0098800 ! inner mitochondrial membrane protein complex
intersection_of: GO:0045283 ! fumarate reductase complex
intersection_of: part_of GO:0005739 ! mitochondrion
relationship: part_of GO:0005739 ! mitochondrion
relationship: part_of GO:0005746 ! mitochondrial respiratory chain

[Term]
id: GO:0005750
name: mitochondrial respiratory chain complex III
namespace: cellular_component
alt_id: GO:0015008
def: "A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1." [GOC:mtg_sensu, ISBN:0198547684]
synonym: "mitochondrial complex III" EXACT [GOC:mcc]
synonym: "mitochondrial cytochrome bc(1) complex" EXACT [GOC:mcc]
synonym: "mitochondrial cytochrome bc1 complex" EXACT [GOC:mcc]
synonym: "mitochondrial electron transport complex III" RELATED [GOC:mcc]
synonym: "mitochondrial ubiquinol-cytochrome c oxidoreductase complex" EXACT [GOC:mcc]
synonym: "mitochondrial ubiquinol-cytochrome-c reductase complex" EXACT [GOC:mcc]
is_a: GO:0045275 ! respiratory chain complex III
is_a: GO:0098800 ! inner mitochondrial membrane protein complex
intersection_of: GO:0045275 ! respiratory chain complex III
intersection_of: part_of GO:0005739 ! mitochondrion
relationship: part_of GO:0005739 ! mitochondrion
relationship: part_of GO:0005746 ! mitochondrial respiratory chain

[Term]
id: GO:0005751
name: mitochondrial respiratory chain complex IV
namespace: cellular_component
alt_id: GO:0005752
def: "A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2)." [GOC:mtg_sensu, ISBN:0198547684]
is_a: GO:0045277 ! respiratory chain complex IV
is_a: GO:0098800 ! inner mitochondrial membrane protein complex
intersection_of: GO:0045277 ! respiratory chain complex IV
intersection_of: part_of GO:0005739 ! mitochondrion
relationship: part_of GO:0005739 ! mitochondrion
relationship: part_of GO:0005746 ! mitochondrial respiratory chain

[Term]
id: GO:0005753
name: mitochondrial proton-transporting ATP synthase complex
namespace: cellular_component
alt_id: GO:0016470
def: "A proton-transporting ATP synthase complex found in the mitochondrial membrane." [GOC:mah, GOC:mtg_sensu]
synonym: "mitochondrial respiratory chain complex V" EXACT []
is_a: GO:0045259 ! proton-transporting ATP synthase complex
is_a: GO:0098800 ! inner mitochondrial membrane protein complex
intersection_of: GO:0045259 ! proton-transporting ATP synthase complex
intersection_of: part_of GO:0005739 ! mitochondrion
relationship: part_of GO:0005739 ! mitochondrion
relationship: part_of GO:0005743 ! mitochondrial inner membrane

[Term]
id: GO:0005754
name: mitochondrial proton-transporting ATP synthase, catalytic core
namespace: cellular_component
def: "The hexamer, comprising three alpha and three beta subunits, that possesses the catalytic activity of the mitochondrial hydrogen-transporting ATP synthase." [GOC:mtg_sensu, PMID:10838056]
is_a: GO:0045267 ! proton-transporting ATP synthase, catalytic core
is_a: GO:0098800 ! inner mitochondrial membrane protein complex
intersection_of: GO:0045267 ! proton-transporting ATP synthase, catalytic core
intersection_of: part_of GO:0005739 ! mitochondrion
relationship: part_of GO:0000275 ! mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)
relationship: part_of GO:0005739 ! mitochondrion

[Term]
id: GO:0005755
name: obsolete hydrogen-transporting ATP synthase, coupling factor CF(0)
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because more specific terms were created.
synonym: "hydrogen-transporting ATP synthase, coupling factor CF(0)" EXACT []
is_obsolete: true
consider: GO:0045263

[Term]
id: GO:0005756
name: mitochondrial proton-transporting ATP synthase, central stalk
namespace: cellular_component
def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the mitochondrial membrane-associated F0 proteins; rotates within the catalytic core during catalysis." [GOC:mtg_sensu, PMID:10838056]
is_a: GO:0045269 ! proton-transporting ATP synthase, central stalk
is_a: GO:0098800 ! inner mitochondrial membrane protein complex
intersection_of: GO:0045269 ! proton-transporting ATP synthase, central stalk
intersection_of: part_of GO:0005739 ! mitochondrion
relationship: part_of GO:0000275 ! mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)
relationship: part_of GO:0005739 ! mitochondrion

[Term]
id: GO:0005757
name: mitochondrial permeability transition pore complex
namespace: cellular_component
def: "A protein complex that connects the inner and outer membranes of animal mitochondria and acts as a pore that can open transiently to allow free diffusion of solutes between the mitochondrial matrix and the cytosol. The pore complex is formed of the voltage-dependent anion channel (VDAC), the adenine nucleotide translocase (ANT) and cyclophilin-D (CyP-D)." [PMID:10393078]
synonym: "mitochondrial PT pore complex" EXACT []
synonym: "MPTP complex" EXACT []
synonym: "PTPC" BROAD [PMID:21760595]
is_a: GO:0046930 ! pore complex
is_a: GO:0098798 ! mitochondrial protein complex
relationship: part_of GO:0005740 ! mitochondrial envelope

[Term]
id: GO:0005758
name: mitochondrial intermembrane space
namespace: cellular_component
alt_id: GO:0031971
def: "The region between the inner and outer lipid bilayers of the mitochondrial envelope." [GOC:mah]
synonym: "mitochondrial envelope lumen" EXACT []
synonym: "mitochondrial membrane lumen" RELATED []
xref: NIF_Subcellular:sao118944228
is_a: GO:0031970 ! organelle envelope lumen
is_a: GO:0044429 ! mitochondrial part
relationship: part_of GO:0005740 ! mitochondrial envelope

[Term]
id: GO:0005759
name: mitochondrial matrix
namespace: cellular_component
alt_id: GO:0031980
def: "The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]
synonym: "mitochondrial lumen" EXACT []
synonym: "mitochondrial stroma" NARROW []
xref: NIF_Subcellular:sao-1899375636
xref: NIF_Subcellular:sao1804523077
xref: Wikipedia:Mitochondrial_matrix
is_a: GO:0044429 ! mitochondrial part
is_a: GO:0070013 ! intracellular organelle lumen

[Term]
id: GO:0005760
name: gamma DNA polymerase complex
namespace: cellular_component
def: "A DNA polymerase complex consisting of a large subunit, responsible for the catalytic activities, and a small accessory subunit. Functions in the replication and repair of mitochondrial DNA." [GOC:jl, PMID:12045093]
is_a: GO:0042575 ! DNA polymerase complex
is_a: GO:0098798 ! mitochondrial protein complex
relationship: part_of GO:0005759 ! mitochondrial matrix

[Term]
id: GO:0005761
name: mitochondrial ribosome
namespace: cellular_component
def: "A ribosome found in the mitochondrion of a eukaryotic cell; contains a characteristic set of proteins distinct from those of cytosolic ribosomes." [GOC:mah, ISBN:0198506732]
synonym: "55S ribosome, mitochondrial" NARROW []
is_a: GO:0000313 ! organellar ribosome
is_a: GO:0044429 ! mitochondrial part
intersection_of: GO:0005840 ! ribosome
intersection_of: part_of GO:0005739 ! mitochondrion
relationship: part_of GO:0005739 ! mitochondrion
relationship: part_of GO:0005759 ! mitochondrial matrix

[Term]
id: GO:0005762
name: mitochondrial large ribosomal subunit
namespace: cellular_component
def: "The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc]
synonym: "39S ribosomal subunit, mitochondrial" NARROW []
is_a: GO:0000315 ! organellar large ribosomal subunit
is_a: GO:0044429 ! mitochondrial part
intersection_of: GO:0015934 ! large ribosomal subunit
intersection_of: part_of GO:0005761 ! mitochondrial ribosome
relationship: part_of GO:0005761 ! mitochondrial ribosome

[Term]
id: GO:0005763
name: mitochondrial small ribosomal subunit
namespace: cellular_component
def: "The smaller of the two subunits of a mitochondrial ribosome." [GOC:mcc]
synonym: "28S ribosomal subunit, mitochondrial" NARROW []
synonym: "mitochondrial ribosomal small subunit complex" EXACT []
synonym: "mitochondrial ribosomal SSU complex" EXACT []
is_a: GO:0000314 ! organellar small ribosomal subunit
is_a: GO:0044429 ! mitochondrial part
intersection_of: GO:0015935 ! small ribosomal subunit
intersection_of: part_of GO:0005761 ! mitochondrial ribosome
relationship: part_of GO:0005761 ! mitochondrial ribosome

[Term]
id: GO:0005764
name: lysosome
namespace: cellular_component
def: "A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_plant
xref: NIF_Subcellular:sao585356902
xref: Wikipedia:Lysosome
is_a: GO:0000323 ! lytic vacuole

[Term]
id: GO:0005765
name: lysosomal membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai]
is_a: GO:0098852 ! lytic vacuole membrane
relationship: part_of GO:0005764 ! lysosome

[Term]
id: GO:0005766
name: primary lysosome
namespace: cellular_component
def: "A lysosome before it has fused with a vesicle or vacuole." [GOC:jl, ISBN:0815316194]
xref: NIF_Subcellular:sao1140587416
is_a: GO:0005764 ! lysosome

[Term]
id: GO:0005767
name: secondary lysosome
namespace: cellular_component
def: "Vacuole formed by the fusion of a lysosome with an organelle (autosome) or with a primary phagosome." [GOC:jl, ISBN:0815316194]
xref: NIF_Subcellular:sao1549842807
is_a: GO:0005764 ! lysosome

[Term]
id: GO:0005768
name: endosome
namespace: cellular_component
def: "A vacuole to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
xref: NIF_Subcellular:sao1720343330
xref: Wikipedia:Endosome
is_a: GO:0005773 ! vacuole
relationship: part_of GO:0012505 ! endomembrane system

[Term]
id: GO:0005769
name: early endosome
namespace: cellular_component
def: "A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]
xref: NIF_Subcellular:nlx_subcell_20090701
is_a: GO:0005768 ! endosome

[Term]
id: GO:0005770
name: late endosome
namespace: cellular_component
def: "A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [NIF_Subcellular:nlx_subcell_20090702, PMID:11964142, PMID:2557062]
synonym: "prevacuolar compartment" EXACT []
synonym: "PVC" BROAD []
xref: NIF_Subcellular:nlx_subcell_20090702
is_a: GO:0005768 ! endosome

[Term]
id: GO:0005771
name: multivesicular body
namespace: cellular_component
def: "A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm." [PMID:11566881, PMID:16533950]
synonym: "multivesicular endosome" EXACT [PMID:12122203]
synonym: "MVB" EXACT []
synonym: "MVE" EXACT [PMID:12122203]
xref: NIF_Subcellular:sao2045955158
is_a: GO:0005770 ! late endosome

[Term]
id: GO:0005773
name: vacuole
namespace: cellular_component
def: "A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732]
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "vacuolar carboxypeptidase Y" RELATED []
xref: Wikipedia:Vacuole
is_a: GO:0043231 ! intracellular membrane-bounded organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005774
name: vacuolar membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell." [GOC:ai]
subset: gosubset_prok
is_a: GO:0044437 ! vacuolar part
is_a: GO:0098588 ! bounding membrane of organelle
is_a: GO:0098805 ! whole membrane

[Term]
id: GO:0005775
name: vacuolar lumen
namespace: cellular_component
def: "The volume enclosed within the vacuolar membrane." [ISBN:0198506732]
is_a: GO:0044437 ! vacuolar part
is_a: GO:0070013 ! intracellular organelle lumen
intersection_of: GO:0031974 ! membrane-enclosed lumen
intersection_of: part_of GO:0005773 ! vacuole
relationship: part_of GO:0005773 ! vacuole

[Term]
id: GO:0005776
name: autophagosome
namespace: cellular_component
def: "A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the vacuole/lysosome for degradation as part of macroautophagy." [GOC:autophagy, ISBN:0198547684, PMID:11099404]
synonym: "autophagic vacuole" EXACT [NIF_Subcellular:sao8663416959]
synonym: "initial autophagic vacuole" RELATED [NIF_Subcellular:sao8663416959]
xref: NIF_Subcellular:sao8663416959
is_a: GO:0005773 ! vacuole

[Term]
id: GO:0005777
name: peroxisome
namespace: cellular_component
alt_id: GO:0019818
def: "A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_plant
subset: goslim_yeast
synonym: "peroxisomal" RELATED [GOC:curators]
synonym: "peroxisome vesicle" BROAD []
xref: NIF_Subcellular:sao499555322
xref: Wikipedia:Peroxisome
is_a: GO:0042579 ! microbody

[Term]
id: GO:0005778
name: peroxisomal membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a peroxisome." [GOC:mah]
synonym: "peroxisome membrane" EXACT []
is_a: GO:0031903 ! microbody membrane
is_a: GO:0044439 ! peroxisomal part

[Term]
id: GO:0005779
name: integral component of peroxisomal membrane
namespace: cellular_component
def: "The component of the peroxisomal membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:mah]
synonym: "integral to peroxisomal membrane" NARROW []
is_a: GO:0031231 ! intrinsic component of peroxisomal membrane
is_a: GO:0031301 ! integral component of organelle membrane
intersection_of: GO:0016021 ! integral component of membrane
intersection_of: part_of GO:0005778 ! peroxisomal membrane
relationship: part_of GO:0005778 ! peroxisomal membrane

[Term]
id: GO:0005780
name: extrinsic component of intraperoxisomal membrane
namespace: cellular_component
def: "The component of the intraperoxisomal membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah]
synonym: "extrinsic to intraperoxisomal membrane" EXACT []
synonym: "intra-peroxisomal peripheral membrane" RELATED []
is_a: GO:0031312 ! extrinsic component of organelle membrane
is_a: GO:0044439 ! peroxisomal part
intersection_of: GO:0019898 ! extrinsic component of membrane
intersection_of: part_of GO:0005778 ! peroxisomal membrane
relationship: part_of GO:0005778 ! peroxisomal membrane

[Term]
id: GO:0005781
name: obsolete peroxisome targeting signal receptor complex
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a single polypeptide rather than a complex; all known peroxisome targeting signal receptors are monomeric.
synonym: "peroxisome targeting signal receptor complex" EXACT []
is_obsolete: true
consider: GO:0000268
consider: GO:0006625
consider: GO:0044439

[Term]
id: GO:0005782
name: peroxisomal matrix
namespace: cellular_component
alt_id: GO:0031909
def: "The volume contained within the membranes of a peroxisome; in many cells the matrix contains a crystalloid core largely composed of urate oxidase." [GOC:curators, ISBN:0815316194]
synonym: "peroxisomal lumen" EXACT []
is_a: GO:0031907 ! microbody lumen
is_a: GO:0044439 ! peroxisomal part

[Term]
id: GO:0005783
name: endoplasmic reticulum
namespace: cellular_component
def: "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
synonym: "ER" EXACT []
xref: NIF_Subcellular:sao1036339110
xref: Wikipedia:Endoplasmic_reticulum
is_a: GO:0043231 ! intracellular membrane-bounded organelle
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0012505 ! endomembrane system

[Term]
id: GO:0005784
name: Sec61 translocon complex
namespace: cellular_component
def: "A translocon complex that contains a core heterotrimer of conserved alpha, beta and gamma subunits, and may contain additional proteins (translocon-associated proteins or TRAPs); in budding yeast the core proteins are Sec61p, Sbh1p, and Sss1p. The Sec61 translocon complex functions in cotranslational and posttranslational translocation events." [GOC:mah, PMID:18166647]
subset: goslim_pir
synonym: "Sec61p-Sbh1p-Sss1p complex" NARROW [GOC:mah]
is_a: GO:0071256 ! translocon complex

[Term]
id: GO:0005785
name: signal recognition particle receptor complex
namespace: cellular_component
def: "A transmembrane heterodimeric protein located in the membrane of the rough endoplasmic reticulum. Both subunits contain GTPase domains with which signal recognition particle interacts. In the presence of GTP and SRP receptor, SRP is released from the ribosome-nascent chain complex." [ISBN:0198506732]
synonym: "docking protein complex" RELATED []
synonym: "SR complex" EXACT []
is_a: GO:0044432 ! endoplasmic reticulum part
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0030867 ! rough endoplasmic reticulum membrane

[Term]
id: GO:0005786
name: signal recognition particle, endoplasmic reticulum targeting
namespace: cellular_component
alt_id: GO:0005855
def: "A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA. Examples of this component are found in Mus musculus, Saccharomyces cerevisiae and Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:0198506732]
synonym: "signal sequence receptor complex" EXACT []
synonym: "SRP" EXACT []
xref: Wikipedia:Signal_recognition_particle
is_a: GO:0048500 ! signal recognition particle

[Term]
id: GO:0005787
name: signal peptidase complex
namespace: cellular_component
def: "A protein complex that is located in the endoplasmic reticulum membrane and cleaves the signal sequence from precursor proteins following their transport out of the cytoplasmic space." [GOC:sgd_curators, PMID:1846444, PMID:7615509]
is_a: GO:0044432 ! endoplasmic reticulum part
is_a: GO:0098796 ! membrane protein complex
is_a: GO:1990234 ! transferase complex
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane

[Term]
id: GO:0005788
name: endoplasmic reticulum lumen
namespace: cellular_component
alt_id: GO:0016022
def: "The volume enclosed by the membranes of the endoplasmic reticulum." [ISBN:0198547684]
synonym: "cisternal lumen" EXACT []
synonym: "endoplasmic reticulum cisterna" EXACT []
synonym: "ER cisterna" EXACT []
synonym: "ER lumen" EXACT []
is_a: GO:0044432 ! endoplasmic reticulum part
is_a: GO:0070013 ! intracellular organelle lumen

[Term]
id: GO:0005789
name: endoplasmic reticulum membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
synonym: "ER membrane" EXACT []
is_a: GO:0044425 ! membrane part
is_a: GO:0044432 ! endoplasmic reticulum part
is_a: GO:0098588 ! bounding membrane of organelle
relationship: part_of GO:0042175 ! nuclear outer membrane-endoplasmic reticulum membrane network

[Term]
id: GO:0005790
name: smooth endoplasmic reticulum
namespace: cellular_component
def: "The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER." [ISBN:0198506732]
synonym: "SER" EXACT []
synonym: "smooth ER" EXACT []
xref: NIF_Subcellular:sao710427438
xref: Wikipedia:Endoplasmic_reticulum#Smooth_endoplasmic_reticulum
is_a: GO:0005783 ! endoplasmic reticulum

[Term]
id: GO:0005791
name: rough endoplasmic reticulum
namespace: cellular_component
def: "The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae." [ISBN:0198506732]
synonym: "RER" EXACT []
synonym: "rough ER" EXACT []
xref: NIF_Subcellular:sao1881364067
xref: Wikipedia:Endoplasmic_reticulum#Rough_endoplasmic_reticulum
is_a: GO:0005783 ! endoplasmic reticulum

[Term]
id: GO:0005792
name: obsolete microsome
namespace: cellular_component
def: "OBSOLETE: Any of the small, heterogeneous, artifactual, vesicular particles, 50-150 nm in diameter, that are formed when some eukaryotic cells are homogenized and that sediment on centrifugation at 100000 g." [ISBN:0198506732]
comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component.
synonym: "microsomal membrane" RELATED []
synonym: "microsome" EXACT []
xref: Wikipedia:Microsome
is_obsolete: true
consider: GO:0043231

[Term]
id: GO:0005793
name: endoplasmic reticulum-Golgi intermediate compartment
namespace: cellular_component
def: "A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi  and Golgi-to-ER transport." [GOC:pr, PMID:16723730]
synonym: "EGTC" EXACT []
synonym: "endoplasmic reticulum-Golgi transport container" EXACT []
synonym: "ER-Golgi intermediate compartment" EXACT []
synonym: "ER-Golgi transport container" EXACT []
synonym: "ERGIC" EXACT []
synonym: "pre-Golgi intermediate compartment" EXACT []
synonym: "vesicular-tubular cluster" EXACT [Wikipedia:Vesicular-tubular_cluster]
synonym: "VTC" EXACT []
xref: Wikipedia:Vesicular-tubular_cluster
is_a: GO:0043231 ! intracellular membrane-bounded organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005794
name: Golgi apparatus
namespace: cellular_component
def: "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
comment: Note that the Golgi apparatus can be located in various places in the cytoplasm. In plants and lower animal cells, the Golgi apparatus exists as many copies of discrete stacks dispersed throughout the cytoplasm, while the Golgi apparatus of interphase mammalian cells is a juxtanuclear, often pericentriolar reticulum, where the discrete Golgi stacks are stitched together to form a compact and interconnected ribbon, sometimes called the Golgi ribbon.
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
synonym: "Golgi" BROAD []
synonym: "Golgi complex" EXACT []
synonym: "Golgi ribbon" NARROW []
xref: NIF_Subcellular:sao451912436
xref: Wikipedia:Golgi_apparatus
is_a: GO:0043231 ! intracellular membrane-bounded organelle
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0012505 ! endomembrane system

[Term]
id: GO:0005795
name: Golgi stack
namespace: cellular_component
alt_id: GO:0016940
def: "The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack." [GOC:mah, ISBN:0815316194]
synonym: "dictyosome" NARROW []
synonym: "Golgi cisternae" EXACT []
is_a: GO:0098791 ! Golgi subcompartment
relationship: part_of GO:0005794 ! Golgi apparatus

[Term]
id: GO:0005796
name: Golgi lumen
namespace: cellular_component
def: "The volume enclosed by the membranes of any cisterna or subcompartment of the Golgi apparatus, including the cis- and trans-Golgi networks." [GOC:mah]
is_a: GO:0044431 ! Golgi apparatus part
is_a: GO:0070013 ! intracellular organelle lumen

[Term]
id: GO:0005797
name: Golgi medial cisterna
namespace: cellular_component
def: "The middle Golgi cisterna (or cisternae)." [ISBN:0815316194]
is_a: GO:0031985 ! Golgi cisterna

[Term]
id: GO:0005798
name: Golgi-associated vesicle
namespace: cellular_component
def: "Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell." [GOC:mah]
comment: Note that this definition includes vesicles that are transiently associated with the Golgi.
synonym: "Golgi vesicle" RELATED []
synonym: "vesicular component" RELATED [NIF_Subcellular:sao138219748]
xref: NIF_Subcellular:sao819927218
is_a: GO:0016023 ! cytoplasmic, membrane-bounded vesicle
is_a: GO:0044431 ! Golgi apparatus part

[Term]
id: GO:0005799
name: obsolete coatomer
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because its position and synonym implied that it confused a coated vesicle with the coat itself.
synonym: "coatomer" EXACT []
synonym: "COPI vesicle" RELATED []
is_obsolete: true
consider: GO:0030126
consider: GO:0030137

[Term]
id: GO:0005800
name: obsolete COPII vesicle
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required.
synonym: "COPII vesicle" EXACT []
is_obsolete: true
consider: GO:0030134

[Term]
id: GO:0005801
name: cis-Golgi network
namespace: cellular_component
def: "The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum." [ISBN:0198506732, ISBN:0815316194]
comment: The CGN is not considered part of the Golgi apparatus but is a separate organelle.
synonym: "cis face" BROAD [NIF_Subcellular:sao632188024]
synonym: "cis Golgi network" EXACT []
synonym: "forming face" RELATED []
synonym: "Golgi cis face" RELATED []
synonym: "Golgi cis-face" RELATED []
xref: NIF_Subcellular:sao632188024
is_a: GO:0043231 ! intracellular membrane-bounded organelle

[Term]
id: GO:0005802
name: trans-Golgi network
namespace: cellular_component
def: "The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]
comment: There are different opinions about whether the TGN should be considered part of the Golgi apparatus or not.  We follow Alberts et al, 1994 (ISBN:0815316194), who consider it to be a part.
synonym: "Golgi trans face" RELATED []
synonym: "Golgi trans-face" RELATED []
synonym: "late Golgi" RELATED [GOC:mah]
synonym: "maturing face" RELATED []
synonym: "TGN" EXACT []
synonym: "trans face" BROAD [NIF_Subcellular:sao1039242387]
synonym: "trans Golgi network" EXACT []
xref: NIF_Subcellular:sao9456487
is_a: GO:0098791 ! Golgi subcompartment
relationship: part_of GO:0005794 ! Golgi apparatus

[Term]
id: GO:0005803
name: obsolete secretory vesicle
namespace: cellular_component
def: "OBSOLETE. A small subcellular vesicle, or granule, surrounded by a single-layered membrane; formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion." [ISBN:0198547684]
comment: This term was made obsolete because it was being used to describe two different components.
synonym: "secretory vesicle" EXACT []
synonym: "transition vesicle" NARROW []
is_obsolete: true
consider: GO:0030133
consider: GO:0030141

[Term]
id: GO:0005804
name: obsolete secretory vesicle membrane
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because its parent was made obsolete.
synonym: "secretory vesicle membrane" EXACT []
is_obsolete: true
consider: GO:0030658
consider: GO:0030667

[Term]
id: GO:0005805
name: obsolete ER-Golgi transport vesicle
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required.
synonym: "ER-Golgi transport vesicle" EXACT []
is_obsolete: true
consider: GO:0030134

[Term]
id: GO:0005806
name: obsolete Golgi-ER transport vesicle
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required.
synonym: "Golgi-ER transport vesicle" EXACT []
is_obsolete: true
consider: GO:0030142

[Term]
id: GO:0005808
name: obsolete Golgi-plasma membrane transport vesicle
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; a personal communication from John Armstrong indicated that a replacement term was not required, as TGN-Golgi transport is likely to be mediated by tubules rather than vesicles.
synonym: "Golgi-plasma membrane transport vesicle" EXACT []
is_obsolete: true
consider: GO:0030133

[Term]
id: GO:0005809
name: obsolete Golgi-vacuole transport vesicle
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required.
synonym: "Golgi-vacuole transport vesicle" EXACT []
is_obsolete: true
consider: GO:0030133

[Term]
id: GO:0005810
name: obsolete endocytotic transport vesicle
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required.
synonym: "endocytotic transport vesicle" EXACT []
is_obsolete: true
replaced_by: GO:0030139

[Term]
id: GO:0005811
name: lipid particle
namespace: cellular_component
def: "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
comment: Note that this term does not refer to vesicles, but instead to structures in which lipids do not necessarily form bilayers.
subset: goslim_chembl
subset: goslim_generic
synonym: "adiposome" EXACT []
synonym: "lipid body" EXACT []
synonym: "lipid droplet" EXACT []
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle

[Term]
id: GO:0005813
name: centrosome
namespace: cellular_component
def: "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]
subset: goslim_pir
xref: Wikipedia:Centrosome
is_a: GO:0005815 ! microtubule organizing center
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle

[Term]
id: GO:0005814
name: centriole
namespace: cellular_component
def: "A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]
comment: In most eukaryotic cells, 'ciliary basal body' (GO:0036064) and 'centriole' (GO:0005814) represent a common entity that cycles through its function in cell division, then ciliogenesis, then cell division again. However, these structures are modified extensively as they transition into each other, and may contain different proteins, specific to each component.
xref: NIF_Subcellular:sao95019936
xref: Wikipedia:Centriole
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle
is_a: GO:0044450 ! microtubule organizing center part
relationship: part_of GO:0005813 ! centrosome

[Term]
id: GO:0005815
name: microtubule organizing center
namespace: cellular_component
def: "An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, http://en.wikipedia.org/wiki/Microtubule_organizing_center, ISBN:0815316194, PMID:17072892, PMID:17245416]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_yeast
synonym: "microtubule organising centre" EXACT []
synonym: "MTOC" EXACT []
xref: Wikipedia:Microtubule_organizing_center
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0015630 ! microtubule cytoskeleton

[Term]
id: GO:0005816
name: spindle pole body
namespace: cellular_component
def: "The microtubule organizing center in fungi; functionally homologous to the animal cell centrosome." [ISBN:0879693568]
synonym: "SPB" EXACT [GOC:mah]
xref: Wikipedia:Spindle_pole_body
is_a: GO:0005815 ! microtubule organizing center
relationship: part_of GO:0000922 ! spindle pole

[Term]
id: GO:0005817
name: obsolete centrosomal mitotic factor
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:clt]
comment: This term was made obsolete because it was not defined.
synonym: "centrosomal mitotic factor" EXACT []
is_obsolete: true

[Term]
id: GO:0005818
name: aster
namespace: cellular_component
def: "An array of microtubules emanating from a spindle pole MTOC that do not connect to kinetochores." [GOC:clt]
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle
is_a: GO:0043234 ! protein complex
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0005819 ! spindle

[Term]
id: GO:0005819
name: spindle
namespace: cellular_component
def: "The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684]
xref: Wikipedia:Spindle_apparatus
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0015630 ! microtubule cytoskeleton

[Term]
id: GO:0005821
name: intermediate layer of spindle pole body
namespace: cellular_component
def: "Structure between the central and outer plaques of the spindle pole body." [PMID:9215630]
is_a: GO:0044450 ! microtubule organizing center part
relationship: part_of GO:0005816 ! spindle pole body

[Term]
id: GO:0005822
name: inner plaque of spindle pole body
namespace: cellular_component
def: "One of three laminate structures that form the spindle pole body; the inner plaque is in the nucleus." [ISBN:0879693568]
is_a: GO:0044450 ! microtubule organizing center part
relationship: part_of GO:0005816 ! spindle pole body

[Term]
id: GO:0005823
name: central plaque of spindle pole body
namespace: cellular_component
def: "One of three laminate structures that form the spindle pole body; the central plaque is embedded in the nuclear envelope." [ISBN:0879693568]
is_a: GO:0044450 ! microtubule organizing center part
relationship: part_of GO:0005816 ! spindle pole body

[Term]
id: GO:0005824
name: outer plaque of spindle pole body
namespace: cellular_component
def: "One of three laminate structures that form the spindle pole body; the outer plaque is in the cytoplasm." [ISBN:0879693568]
is_a: GO:0044450 ! microtubule organizing center part
relationship: part_of GO:0005816 ! spindle pole body

[Term]
id: GO:0005825
name: half bridge of spindle pole body
namespace: cellular_component
def: "Structure adjacent to the plaques of the spindle pole body." [ISBN:0879693568]
is_a: GO:0044450 ! microtubule organizing center part
relationship: part_of GO:0005816 ! spindle pole body

[Term]
id: GO:0005826
name: actomyosin contractile ring
namespace: cellular_component
alt_id: GO:0030480
def: "A cytoskeletal structure composed of actin filaments and myosin that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the spindle, i.e. the cell division plane. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two daughter cells. In animal cells, the contractile ring is located inside the plasma membrane at the location of the cleavage furrow. In budding fungal cells, e.g. mitotic S. cerevisiae cells, the contractile ring forms beneath the plasma membrane at the mother-bud neck before mitosis." [GOC:expert_jrp, GOC:sgd_curators, ISBN:0805319409, ISBN:0815316194]
synonym: "actomyosin ring" RELATED []
synonym: "CAR" EXACT []
synonym: "constriction ring" RELATED []
synonym: "contractile actomyosin ring" EXACT []
synonym: "cytokinetic ring" RELATED []
is_a: GO:0032155 ! cell division site part
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044448 ! cell cortex part
is_a: GO:0070938 ! contractile ring
relationship: part_of GO:0030864 ! cortical actin cytoskeleton

[Term]
id: GO:0005827
name: polar microtubule
namespace: cellular_component
def: "Any of the spindle microtubules that come from each pole and overlap at the spindle midzone. This interdigitating structure consisting of antiparallel microtubules is responsible for pushing the poles of the spindle apart." [ISBN:0815316194]
synonym: "pole-to-pole microtubule" EXACT []
is_a: GO:0005876 ! spindle microtubule
intersection_of: GO:0005876 ! spindle microtubule
intersection_of: part_of GO:0000922 ! spindle pole
relationship: part_of GO:0000922 ! spindle pole

[Term]
id: GO:0005828
name: kinetochore microtubule
namespace: cellular_component
def: "Any of the spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic or meiotic chromosome segregation." [ISBN:0815316194]
synonym: "pole-to-kinetochore microtubule" EXACT []
is_a: GO:0005876 ! spindle microtubule

[Term]
id: GO:0005829
name: cytosol
namespace: cellular_component
def: "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
subset: goslim_aspergillus
subset: goslim_chembl
subset: goslim_generic
subset: goslim_plant
subset: gosubset_prok
xref: NIF_Subcellular:sao101633890
xref: Wikipedia:Cytosol
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005831
name: steroid hormone aporeceptor complex
namespace: cellular_component
def: "A protein complex consisting of a steroid receptor associated with nonreceptor proteins, minimally a dimer of Hsp90 and a monomer of hsp56/FKBP59; forms in the absence of bound ligand." [PMID:7493981]
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0005832
name: chaperonin-containing T-complex
namespace: cellular_component
def: "A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor." [GOC:sgd_curators, PMID:11580267]
synonym: "CCT particle" EXACT []
synonym: "TriC" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0005833
name: hemoglobin complex
namespace: cellular_component
def: "An iron-containing, oxygen carrying complex. In vertebrates it is made up of two pairs of associated globin polypeptide chains, each chain carrying a noncovalently bound heme prosthetic group." [GOC:jl, ISBN:0198506732]
synonym: "haemoglobin complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0005834
name: heterotrimeric G-protein complex
namespace: cellular_component
def: "Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G-protein coupled receptors to an effector protein." [ISBN:0198547684]
comment: See also the molecular function term 'G-protein coupled receptor activity ; GO:0004930'.
subset: gosubset_prok
synonym: "heterotrimeric G-protein GTPase activity" RELATED []
synonym: "heterotrimeric G-protein GTPase, alpha-subunit" NARROW []
synonym: "heterotrimeric G-protein GTPase, beta-subunit" NARROW []
synonym: "heterotrimeric G-protein GTPase, gamma-subunit" NARROW []
is_a: GO:0044424 ! intracellular part
is_a: GO:0098797 ! plasma membrane protein complex
is_a: GO:1902494 ! catalytic complex
relationship: part_of GO:0031234 ! extrinsic component of cytoplasmic side of plasma membrane

[Term]
id: GO:0005835
name: fatty acid synthase complex
namespace: cellular_component
alt_id: GO:0031373
alt_id: GO:0031374
def: "A multienzyme complex that catalyses the synthesis of fatty acids from acetyl CoA." [GOC:pde, GOC:sgd_curators, ISBN:0716746840]
subset: goslim_pir
subset: gosubset_prok
synonym: "cytosolic FAS complex" EXACT []
synonym: "cytosolic fatty acid synthase complex" EXACT []
synonym: "cytosolic type I FAS complex" EXACT []
synonym: "cytosolic type I fatty acid synthase complex" EXACT []
synonym: "FAS complex" EXACT []
synonym: "fatty acid synthetase complex" EXACT []
synonym: "holo-[acyl-carrier-protein] synthase complex" RELATED []
xref: Wikipedia:Fatty_acid_synthetase_complex
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0005836
name: fatty-acyl-CoA synthase complex
namespace: cellular_component
def: "A protein complex that possesses fatty-acyl-CoA synthase activity." [BRENDA:2.3.1.86, GOC:mah]
comment: Note that fatty acid synthetases of vertebrates and yeast are stable enzyme complexes of multifunctional polypeptide chains, whereas the fatty acid synthetases of plants and E. coli consist of non-associated individual enzymes.
synonym: "fatty acyl CoA synthase complex" EXACT [GOC:curators]
is_a: GO:0044445 ! cytosolic part
is_a: GO:1990234 ! transferase complex

[Term]
id: GO:0005837
name: obsolete 26S proteasome
namespace: cellular_component
def: "OBSOLETE. A large multisubunit protease found in the cytosol that recognizes, unfolds, and digests protein substrates that have been marked for degradation by the attachment of a ubiquitin group. Individual subcomplexes of the complete 26S proteasome are involved in these different tasks: the ATP-dependent 19S caps are believed to unfold substrates and feed them to the actual protease, the 20S proteasome." [PMID:10410804]
comment: This term was made obsolete because its definition was inaccurate.
synonym: "26S proteasome" EXACT []
is_obsolete: true
consider: GO:0000502

[Term]
id: GO:0005838
name: proteasome regulatory particle
namespace: cellular_component
def: "A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex." [GOC:mtg_sensu, GOC:rb]
synonym: "19S regulatory particle" NARROW []
synonym: "modulator complex" RELATED [CORUM:28]
synonym: "PA700 proteasome activator" NARROW []
synonym: "PA700-dependent proteasome activator" EXACT [CORUM:28]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0022624 ! proteasome accessory complex

[Term]
id: GO:0005839
name: proteasome core complex
namespace: cellular_component
alt_id: GO:0000503
def: "A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex." [GOC:rb, PMID:10806206]
synonym: "20S core complex" NARROW []
synonym: "20S proteasome" NARROW [GOC:cjk]
synonym: "macropain" EXACT []
synonym: "PA28gamma-20S proteasome" NARROW [CORUM:194]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0000502 ! proteasome complex

[Term]
id: GO:0005840
name: ribosome
namespace: cellular_component
alt_id: GO:0033279
def: "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "free ribosome" NARROW [NIF_Subcellular:sao1139385046]
synonym: "membrane bound ribosome" NARROW [NIF_Subcellular:sao1291545653]
synonym: "ribosomal RNA" RELATED []
xref: NIF_Subcellular:sao1429207766
xref: Wikipedia:Ribosome
is_a: GO:0030529 ! intracellular ribonucleoprotein complex
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005844
name: polysome
namespace: cellular_component
def: "A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro." [ISBN:0198506732, NIF_Subcellular:sao1038025871]
subset: goslim_pir
synonym: "polyribosome" EXACT [NIF_Subcellular:sao1038025871]
xref: NIF_Subcellular:sao1038025871
xref: Wikipedia:Polysome
is_a: GO:0030529 ! intracellular ribonucleoprotein complex

[Term]
id: GO:0005845
name: mRNA cap binding complex
namespace: cellular_component
def: "Any protein complex that binds to an mRNA cap at any time in the lifetime of the mRNA." [GOC:jid]
synonym: "mRNA cap complex" RELATED []
is_a: GO:0034518 ! RNA cap binding complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0005846
name: nuclear cap binding complex
namespace: cellular_component
def: "A conserved heterodimeric protein complex that binds to the 5' terminal cap structure m7G(5')ppp(5')N of nascent eukaryotic RNA polymerase II transcripts such as pre-mRNA and U snRNA. The consists of proteins known as CBP20 and CBP80, binds to cap structures in the nucleus, and is involved in pre-mRNA splicing, 3'-end formation, and RNA nuclear export." [PMID:16043498]
comment: Note that this complex can be found in the cytoplasm as well as the nucleus.
synonym: "CBC" RELATED []
synonym: "mRNA cap binding complex" NARROW []
synonym: "NCBP-NIP1 complex" NARROW []
synonym: "snRNA cap binding complex" NARROW []
is_a: GO:0034518 ! RNA cap binding complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0005847
name: mRNA cleavage and polyadenylation specificity factor complex
namespace: cellular_component
def: "A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal." [PMID:14749727]
synonym: "CFII complex" RELATED []
synonym: "cleavage and polyadenylylation specificity factor activity" RELATED []
synonym: "CPF complex" NARROW []
synonym: "CPSF complex" NARROW []
is_a: GO:0005849 ! mRNA cleavage factor complex

[Term]
id: GO:0005848
name: mRNA cleavage stimulating factor complex
namespace: cellular_component
def: "A protein complex required for mRNA cleavage but not for poly(A) addition." [GOC:mah, PMID:10357856]
synonym: "cleavage stimulation factor activity" RELATED []
synonym: "CstF complex" NARROW []
is_a: GO:0005849 ! mRNA cleavage factor complex

[Term]
id: GO:0005849
name: mRNA cleavage factor complex
namespace: cellular_component
def: "Any macromolecular complex involved in cleavage or polyadenylation of mRNA molecules." [GOC:mah, PMID:10357856]
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part

[Term]
id: GO:0005850
name: eukaryotic translation initiation factor 2 complex
namespace: cellular_component
def: "Complex of three heterogeneous polypeptide chains, that form a ternary complex with initiator methionyl-tRNA and GTP. This ternary complex binds to free 40S subunit, which subsequently binds the 5' end of mRNA." [PMID:10216940]
synonym: "eIF-2" EXACT []
synonym: "eIF2" EXACT [GOC:mah]
xref: Wikipedia:EIF-2
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005851
name: eukaryotic translation initiation factor 2B complex
namespace: cellular_component
def: "A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon." [PMID:9438375]
synonym: "eIF-2B" EXACT []
synonym: "eif2B" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005852
name: eukaryotic translation initiation factor 3 complex
namespace: cellular_component
def: "A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs." [PMID:15904532]
synonym: "eIF-3" EXACT []
synonym: "eIF3" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005853
name: eukaryotic translation elongation factor 1 complex
namespace: cellular_component
def: "A multisubunit nucleotide exchange complex that binds GTP and aminoacyl-tRNAs, and catalyzes their codon-dependent placement at the A-site of the ribosome. In humans, the complex is composed of four subunits, alpha, beta, delta and gamma." [GOC:jl, PMID:10216950]
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005854
name: nascent polypeptide-associated complex
namespace: cellular_component
def: "A heterodimeric protein complex that can reversibly bind to ribosomes, and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome." [PMID:12475173, PMID:7568149]
synonym: "NAC" EXACT []
synonym: "NACA" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005856
name: cytoskeleton
namespace: cellular_component
def: "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
xref: Wikipedia:Cytoskeleton
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle

[Term]
id: GO:0005858
name: axonemal dynein complex
namespace: cellular_component
def: "A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:cilia, GOC:hla, GOC:krc, ISBN:0815316194]
synonym: "axonemal dynein heavy chain" NARROW []
synonym: "axonemal dynein intermediate chain" NARROW []
synonym: "axonemal dynein intermediate light chain" NARROW []
synonym: "axonemal dynein light chain" NARROW []
is_a: GO:0030286 ! dynein complex
is_a: GO:0044447 ! axoneme part
intersection_of: GO:0030286 ! dynein complex
intersection_of: part_of GO:0005930 ! axoneme
relationship: part_of GO:0005930 ! axoneme

[Term]
id: GO:0005859
name: muscle myosin complex
namespace: cellular_component
def: "A filament of myosin found in a muscle cell of any type." [GOC:mah]
is_a: GO:0016460 ! myosin II complex
is_a: GO:0044449 ! contractile fiber part
intersection_of: GO:0016460 ! myosin II complex
intersection_of: part_of GO:0043292 ! contractile fiber
relationship: part_of GO:0043292 ! contractile fiber

[Term]
id: GO:0005861
name: troponin complex
namespace: cellular_component
def: "A complex of accessory proteins (typically troponin T, troponin I and troponin C) found associated with actin in muscle thin filaments; involved in calcium regulation of muscle contraction." [ISBN:0815316194]
is_a: GO:0043234 ! protein complex
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044449 ! contractile fiber part
relationship: part_of GO:0005865 ! striated muscle thin filament

[Term]
id: GO:0005862
name: muscle thin filament tropomyosin
namespace: cellular_component
def: "A form of the tropomyosin dimer found associated with actin and the troponin complex in muscle thin filaments." [ISBN:0815316194]
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044449 ! contractile fiber part
relationship: part_of GO:0005865 ! striated muscle thin filament

[Term]
id: GO:0005863
name: striated muscle myosin thick filament
namespace: cellular_component
def: "Bipolar filaments formed of polymers of a muscle-specific myosin II isoform, found in the middle of sarcomeres in myofibrils." [GOC:mtg_muscle, ISBN:0815316194]
is_a: GO:0005859 ! muscle myosin complex
is_a: GO:0032982 ! myosin filament
is_a: GO:0036379 ! myofilament
relationship: part_of GO:0030017 ! sarcomere

[Term]
id: GO:0005865
name: striated muscle thin filament
namespace: cellular_component
def: "Filaments formed of actin and associated proteins; attached to Z discs at either end of sarcomeres in myofibrils." [ISBN:0815316194]
is_a: GO:0036379 ! myofilament
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0015629 ! actin cytoskeleton
relationship: part_of GO:0030017 ! sarcomere

[Term]
id: GO:0005868
name: cytoplasmic dynein complex
namespace: cellular_component
def: "Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains." [GOC:cilia, GOC:hla, GOC:krc, GOC:mah, PMID:12600311]
comment: Note that this term is labelled based on phylogenetic classification and community usage, rather than strict cellular localization. Cytoplasmic dynein complexes may contain ciliary dyneins; therefore the term is not linked to 'cytoplasm'. Cytoplasmic dynein complexes do not contain axonemal dyneins; see GO:0005858 axonemal dynein complex.
synonym: "cytoplasmic dynein heavy chain" NARROW []
synonym: "cytoplasmic dynein intermediate chain" NARROW []
synonym: "cytoplasmic dynein intermediate light chain" NARROW []
synonym: "cytoplasmic dynein light chain" NARROW []
is_a: GO:0030286 ! dynein complex

[Term]
id: GO:0005869
name: dynactin complex
namespace: cellular_component
def: "A 20S multiprotein assembly of total mass about 1.2 MDa that activates dynein-based activity in vivo. A large structural component of the complex is an actin-like 40 nm filament composed of actin-related protein, to which other components attach." [ISBN:0198506732]
is_a: GO:0005875 ! microtubule associated complex
relationship: part_of GO:0015629 ! actin cytoskeleton

[Term]
id: GO:0005870
name: actin capping protein of dynactin complex
namespace: cellular_component
def: "A heterodimer consisting of alpha and beta subunits that binds to and caps the barbed ends of actin filaments, nucleates the polymerization of actin monomers but does not sever actin filaments, and which is a part of the dynactin complex." [GOC:jl, PMID:18221362, PMID:18544499]
is_a: GO:0008290 ! F-actin capping protein complex
intersection_of: GO:0008290 ! F-actin capping protein complex
intersection_of: part_of GO:0005869 ! dynactin complex
relationship: part_of GO:0005869 ! dynactin complex

[Term]
id: GO:0005871
name: kinesin complex
namespace: cellular_component
def: "Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html]
is_a: GO:0005875 ! microtubule associated complex

[Term]
id: GO:0005872
name: minus-end kinesin complex
namespace: cellular_component
def: "Any complex that includes a dimer of molecules from the kinesin superfamily and any associated proteins, and moves towards the minus end of a microtubule." [GOC:mah]
is_a: GO:0005871 ! kinesin complex

[Term]
id: GO:0005873
name: plus-end kinesin complex
namespace: cellular_component
def: "Any complex that includes a dimer of molecules from the kinesin superfamily and any associated proteins, and moves towards the plus end of a microtubule." [GOC:mah]
is_a: GO:0005871 ! kinesin complex

[Term]
id: GO:0005874
name: microtubule
namespace: cellular_component
def: "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
synonym: "microtubuli" EXACT []
synonym: "microtubulus" EXACT []
synonym: "neurotubule" NARROW [NIF_Subcellular:sao248349196]
xref: NIF_Subcellular:sao1846835077
xref: Wikipedia:Microtubule
is_a: GO:0099513 ! polymeric cytoskeletal fiber
relationship: part_of GO:0015630 ! microtubule cytoskeleton

[Term]
id: GO:0005875
name: microtubule associated complex
namespace: cellular_component
def: "Any multimeric complex connected to a microtubule." [GOC:jl]
is_a: GO:0043234 ! protein complex
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0015630 ! microtubule cytoskeleton

[Term]
id: GO:0005876
name: spindle microtubule
namespace: cellular_component
def: "Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole." [ISBN:0815316194]
is_a: GO:0005874 ! microtubule
intersection_of: GO:0005874 ! microtubule
intersection_of: part_of GO:0005819 ! spindle
relationship: part_of GO:0005819 ! spindle

[Term]
id: GO:0005879
name: axonemal microtubule
namespace: cellular_component
def: "A microtubule in the axoneme of a eukaryotic cilium or flagellum; an axoneme contains nine modified doublet microtubules, which may or may not surround a pair of single microtubules." [GOC:cilia, ISBN:0815316194]
is_a: GO:0005874 ! microtubule
is_a: GO:0044447 ! axoneme part
intersection_of: GO:0005874 ! microtubule
intersection_of: part_of GO:0005930 ! axoneme
relationship: part_of GO:0005930 ! axoneme

[Term]
id: GO:0005880
name: nuclear microtubule
namespace: cellular_component
def: "Any microtubule in the nucleus of a cell." [GOC:mah]
is_a: GO:0005874 ! microtubule
is_a: GO:0044428 ! nuclear part
intersection_of: GO:0005874 ! microtubule
intersection_of: part_of GO:0005634 ! nucleus
relationship: part_of GO:0005634 ! nucleus

[Term]
id: GO:0005881
name: cytoplasmic microtubule
namespace: cellular_component
def: "Any microtubule in the cytoplasm of a cell." [GOC:mah]
synonym: "non-spindle-associated astral microtubule" NARROW []
is_a: GO:0005874 ! microtubule
is_a: GO:0044444 ! cytoplasmic part
intersection_of: GO:0005874 ! microtubule
intersection_of: part_of GO:0005737 ! cytoplasm
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0005882
name: intermediate filament
namespace: cellular_component
def: "A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins." [http://www.cytochemistry.net/Cell-biology/intermediate_filaments.htm, ISBN:0198506732]
synonym: "intermediate filament associated protein" RELATED []
synonym: "type I intermediate filament associated protein" RELATED []
synonym: "type II intermediate filament associated protein" RELATED []
xref: FMA:63851
xref: NIF_Subcellular:sao952483289
xref: Wikipedia:Intermediate_filament
is_a: GO:0099513 ! polymeric cytoskeletal fiber
relationship: part_of GO:0045111 ! intermediate filament cytoskeleton

[Term]
id: GO:0005883
name: neurofilament
namespace: cellular_component
def: "A type of intermediate filament found in the core of neuronal axons. Neurofilaments are heteropolymers composed of three type IV polypeptides: NF-L, NF-M, and NF-H (for low, middle, and high molecular weight). Neurofilaments are responsible for the radial growth of an axon and determine axonal diameter." [ISBN:0198506732, ISBN:0716731363, ISBN:0815316194]
synonym: "type IV intermediate filament" EXACT []
xref: NIF_Subcellular:sao1316272517
xref: Wikipedia:Neurofilament
is_a: GO:0005882 ! intermediate filament
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005884
name: actin filament
namespace: cellular_component
def: "A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339]
synonym: "microfilament" EXACT []
xref: FMA:63850
xref: NIF_Subcellular:sao1588493326
xref: Wikipedia:Actin
is_a: GO:0099513 ! polymeric cytoskeletal fiber
relationship: part_of GO:0015629 ! actin cytoskeleton

[Term]
id: GO:0005885
name: Arp2/3 protein complex
namespace: cellular_component
def: "A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5), and functions in the nucleation of branched actin filaments." [GOC:jl, GOC:vw, PMID:12479800]
is_a: GO:0043234 ! protein complex
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0015629 ! actin cytoskeleton

[Term]
id: GO:0005886
name: plasma membrane
namespace: cellular_component
alt_id: GO:0005904
def: "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "bacterial inner membrane" NARROW []
synonym: "cell membrane" EXACT []
synonym: "cellular membrane" EXACT [NIF_Subcellular:sao6433132645]
synonym: "cytoplasmic membrane" EXACT []
synonym: "inner endospore membrane" NARROW []
synonym: "juxtamembrane" BROAD []
synonym: "plasma membrane lipid bilayer" NARROW [GOC:mah]
synonym: "plasmalemma" EXACT []
xref: NIF_Subcellular:sao1663586795
xref: Wikipedia:Cell_membrane
is_a: GO:0016020 ! membrane
is_a: GO:0044464 ! cell part
relationship: part_of GO:0071944 ! cell periphery

[Term]
id: GO:0005887
name: integral component of plasma membrane
namespace: cellular_component
def: "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
subset: gosubset_prok
synonym: "integral to plasma membrane" NARROW []
is_a: GO:0016021 ! integral component of membrane
is_a: GO:0031226 ! intrinsic component of plasma membrane
intersection_of: GO:0016021 ! integral component of membrane
intersection_of: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0005886 ! plasma membrane

[Term]
id: GO:0005888
name: obsolete proteoglycan integral to plasma membrane
namespace: cellular_component
def: "OBSOLETE. Penetrating at least one phospholipid bilayer of a plasma membrane and consisting of proteoglycan. Also refers to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:go_curators]
comment: This term was made obsolete because it describes the composition (i.e. proteoglycan) and not the location of a gene product.
synonym: "proteoglycan integral to plasma membrane" EXACT []
is_obsolete: true
replaced_by: GO:0005887

[Term]
id: GO:0005889
name: hydrogen:potassium-exchanging ATPase complex
namespace: cellular_component
def: "A protein complex that possesses hydrogen:potassium-exchanging ATPase activity; characterized in animal cells, where it maintains ionic gradients of K+ at the expense of ATP hydrolysis; The complex contains two obligatory subunits, the catalytic alpha subunit and a glycosylated beta subunit; two additional subunits, gamma and channel-inducing factor (CHIF), may also be present." [PMID:11756431]
synonym: "hydrogen/potassium-exchanging ATPase complex" EXACT []
synonym: "proton pump" BROAD []
is_a: GO:0090533 ! cation-transporting ATPase complex
is_a: GO:0098797 ! plasma membrane protein complex
relationship: part_of GO:0005887 ! integral component of plasma membrane

[Term]
id: GO:0005890
name: sodium:potassium-exchanging ATPase complex
namespace: cellular_component
def: "Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior." [ISBN:0198506732]
synonym: "sodium pump" BROAD []
synonym: "sodium/potassium-exchanging ATPase complex" EXACT []
is_a: GO:0090533 ! cation-transporting ATPase complex
is_a: GO:0098797 ! plasma membrane protein complex
relationship: part_of GO:0005887 ! integral component of plasma membrane

[Term]
id: GO:0005891
name: voltage-gated calcium channel complex
namespace: cellular_component
def: "A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential." [GOC:mah]
subset: goslim_pir
synonym: "voltage gated calcium channel complex" EXACT []
synonym: "voltage-dependent calcium channel complex" EXACT []
synonym: "voltage-sensitive calcium channel complex" EXACT []
is_a: GO:0034704 ! calcium channel complex
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0005892
name: acetylcholine-gated channel complex
namespace: cellular_component
def: "A homo- or hetero-pentameric protein complex that forms a transmembrane channel through which ions may pass in response to acetylcholine binding." [GOC:bf, GOC:mah, PMID:12381728, PMID:15579462]
synonym: "nicotinic acetylcholine receptor" BROAD []
synonym: "nicotinic acetylcholine-gated receptor-channel complex" EXACT [GOC:bf]
is_a: GO:0034702 ! ion channel complex
is_a: GO:0098802 ! plasma membrane receptor complex
relationship: part_of GO:0005887 ! integral component of plasma membrane

[Term]
id: GO:0005893
name: interleukin-2 receptor complex
namespace: cellular_component
def: "A protein complex that binds interleukin-2; comprises alpha, beta, and gamma subunits." [GOC:mah, PMID:3116143, PMID:8266078]
synonym: "IL-2 receptor complex" EXACT [GOC:add]
is_a: GO:0098802 ! plasma membrane receptor complex
relationship: part_of GO:0005887 ! integral component of plasma membrane

[Term]
id: GO:0005894
name: interleukin-3 receptor complex
namespace: cellular_component
def: "A protein complex that binds interleukin-3; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-3 receptor, whereas the beta chain is shared with the receptors for granulocyte-macrophage colony-stimulating factor and interleukin-5." [PMID:11839579]
synonym: "IL-3 receptor complex" EXACT [GOC:add]
is_a: GO:0098802 ! plasma membrane receptor complex
relationship: part_of GO:0005887 ! integral component of plasma membrane

[Term]
id: GO:0005895
name: interleukin-5 receptor complex
namespace: cellular_component
def: "A protein complex that binds interleukin-3; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-5 receptor, whereas the beta chain is shared with the receptors for granulocyte-macrophage colony-stimulating factor and interleukin-3." [GOC:mah, PMID:11312115, PMID:11839579]
synonym: "IL-5 receptor complex" EXACT [GOC:add]
is_a: GO:0098802 ! plasma membrane receptor complex
relationship: part_of GO:0005887 ! integral component of plasma membrane

[Term]
id: GO:0005896
name: interleukin-6 receptor complex
namespace: cellular_component
def: "A hexameric protein complex consisting of two molecules each of interleukin-6, interleukin-6 receptor alpha chain, and gp-130." [PMID:8083235]
synonym: "IL-6 receptor complex" EXACT [GOC:add]
is_a: GO:0098802 ! plasma membrane receptor complex
relationship: part_of GO:0005887 ! integral component of plasma membrane

[Term]
id: GO:0005897
name: interleukin-9 receptor complex
namespace: cellular_component
def: "A protein complex that binds interleukin-9; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-9 receptor, whereas the beta chain is shared with the receptors for several other interleukins." [GOC:mah, PMID:10642536]
synonym: "IL-9 receptor complex" EXACT [GOC:add]
is_a: GO:0098802 ! plasma membrane receptor complex
relationship: part_of GO:0005887 ! integral component of plasma membrane

[Term]
id: GO:0005898
name: interleukin-13 receptor complex
namespace: cellular_component
def: "A protein complex that binds interleukin-13; consists of two chains, interleukin-13 receptor alpha1 chain and interleukin-4 receptor alpha chain." [PMID:8552669, PMID:9013879]
synonym: "IL-13 receptor complex" EXACT [GOC:add]
is_a: GO:0098802 ! plasma membrane receptor complex
relationship: part_of GO:0005887 ! integral component of plasma membrane

[Term]
id: GO:0005899
name: insulin receptor complex
namespace: cellular_component
def: "A disulfide-bonded, heterotetrameric receptor complex. The alpha chains are entirely extracellular, while each beta chain has one transmembrane domain. The ligand binds to the alpha subunit extracellular domain and the kinase is associated with the beta subunit intracellular domain." [ISBN:0198506732]
is_a: GO:0098802 ! plasma membrane receptor complex
is_a: GO:1902911 ! protein kinase complex
relationship: part_of GO:0005887 ! integral component of plasma membrane

[Term]
id: GO:0005900
name: oncostatin-M receptor complex
namespace: cellular_component
def: "A heterodimeric receptor for the cytokine oncostatin-M (OSM). In humans the receptor complex is made up of the gene products gp130 and OSMR-beta." [GOC:jl, PMID:8999038]
is_a: GO:0098802 ! plasma membrane receptor complex
relationship: part_of GO:0005887 ! integral component of plasma membrane

[Term]
id: GO:0005901
name: caveola
namespace: cellular_component
alt_id: GO:0016599
def: "A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis.  Caveolae may be pinched off to form free vesicles within the cytoplasm." [GOC:mah, ISBN:0721662544, PMID:16645198]
synonym: "caveolae" EXACT []
synonym: "caveolar membrane" RELATED []
xref: Wikipedia:Caveolae
is_a: GO:0044853 ! plasma membrane raft

[Term]
id: GO:0005902
name: microvillus
namespace: cellular_component
def: "Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells." [ISBN:0813516194]
comment: Note that this term refers to a projection from a single cell, and should not be confused with 'microvillus' as used to refer to a multicellular structure such as that found in the placenta.
subset: goslim_pir
synonym: "microvilli" RELATED [NIF_Subcellular:sao671419673]
xref: NIF_Subcellular:sao671419673
xref: Wikipedia:Microvillus
is_a: GO:0098858 ! actin-based cell projection
relationship: has_part GO:0032432 ! actin filament bundle

[Term]
id: GO:0005903
name: brush border
namespace: cellular_component
def: "The dense covering of microvilli on the apical surface of a epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell." [GOC:sl, ISBN:0815316194]
subset: goslim_pir
xref: Wikipedia:Brush_border
is_a: GO:0098862 ! cluster of actin-based cell projections
relationship: has_part GO:0005902 ! microvillus

[Term]
id: GO:0005905
name: coated pit
namespace: cellular_component
def: "A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes." [GOC:mah, ISBN:0198506732, NIF_Subcellular:sao1969557946, PMID:10559856, PMID:17284835]
xref: NIF_Subcellular:sao1969557946
is_a: GO:0044464 ! cell part
is_a: GO:0098589 ! membrane region
relationship: part_of GO:0012505 ! endomembrane system

[Term]
id: GO:0005906
name: obsolete clathrin adaptor
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it was positioned incorrectly, so the replacement term has a definition different from what this term appeared to mean.
synonym: "adaptin" RELATED []
synonym: "clathrin adaptor" EXACT []
is_obsolete: true
replaced_by: GO:0030119

[Term]
id: GO:0005907
name: obsolete HA1 clathrin adaptor
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology was erroneous.
synonym: "AP1" RELATED []
synonym: "HA1 clathrin adaptor" EXACT []
is_obsolete: true
consider: GO:0030121

[Term]
id: GO:0005908
name: obsolete HA2 clathrin adaptor
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology was erroneous.
synonym: "AP2" RELATED []
synonym: "HA2 clathrin adaptor" EXACT []
is_obsolete: true
consider: GO:0030122

[Term]
id: GO:0005911
name: cell-cell junction
namespace: cellular_component
def: "A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals." [GOC:dgh, GOC:hb, GOC:mah]
synonym: "intercellular junction" EXACT [NIF_Subcellular:sao1395777368]
xref: NIF_Subcellular:sao1922892319
is_a: GO:0030054 ! cell junction

[Term]
id: GO:0005912
name: adherens junction
namespace: cellular_component
def: "A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
xref: Wikipedia:Adherens_junction
is_a: GO:0070161 ! anchoring junction

[Term]
id: GO:0005913
name: cell-cell adherens junction
namespace: cellular_component
def: "An adherens junction which connects a cell to another cell." [GOC:hb]
is_a: GO:0005911 ! cell-cell junction
is_a: GO:0005912 ! adherens junction

[Term]
id: GO:0005914
name: spot adherens junction
namespace: cellular_component
def: "A small cell-cell adherens junction assembled during the cellularization stage of insect embyrogenesis; spot adherens junctions later fuse to form the zonula adherens." [PMID:11700298]
synonym: "dense plaque" BROAD []
synonym: "punctum adherens" EXACT []
is_a: GO:0005913 ! cell-cell adherens junction

[Term]
id: GO:0005915
name: zonula adherens
namespace: cellular_component
def: "A cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells." [ISBN:0815316208]
synonym: "adhesion belt" EXACT []
synonym: "belt desmosome" EXACT []
synonym: "fascia adhaerens" EXACT []
synonym: "intermediate junction" EXACT []
synonym: "zonula adhaerens" EXACT []
xref: NIF_Subcellular:sao1400623473
is_a: GO:0005913 ! cell-cell adherens junction
relationship: part_of GO:0043296 ! apical junction complex

[Term]
id: GO:0005916
name: fascia adherens
namespace: cellular_component
def: "A cell-cell adherens junction that contains the transmembrane protein N-cadherin, which interacts with identical molecules from neighboring cells to form a tight mechanical intercellular link; forms a large portion of the intercalated disc, the structure at which myofibrils terminate in cardiomyocytes." [GOC:mtg_muscle, PMID:11732910]
xref: Wikipedia:Fascia_adherens
is_a: GO:0005913 ! cell-cell adherens junction
relationship: part_of GO:0014704 ! intercalated disc

[Term]
id: GO:0005917
name: nephrocyte diaphragm
namespace: cellular_component
def: "A specialized cell-cell junction found between nephrocytes of the insect kidney, which is adapted for filtration of hemolymph. The insect nephrocyte is anatomically and functionally similar to the glomerular podocyte of vertebrates." [GOC:mtg_kidney_jan10, GOC:sart, PMID:18971929]
synonym: "nephrocyte junction" RELATED [PMID:8314002]
is_a: GO:0036056 ! filtration diaphragm

[Term]
id: GO:0005918
name: septate junction
namespace: cellular_component
def: "A cell-cell junction that forms a continuous band around each cell in an epithelium; within the septate junction the membranes of adjacent cells maintain a constant distance of approximately 15 nm; found in invertebrates." [ISBN:0815332181, PMID:11700298]
synonym: "septate desmosome" RELATED []
xref: NIF_Subcellular:sao427941916
is_a: GO:0070160 ! occluding junction
relationship: part_of GO:0043296 ! apical junction complex

[Term]
id: GO:0005919
name: pleated septate junction
namespace: cellular_component
def: "A septate junction in which regular arrays of electron-dense septae span the intermembrane space." [PMID:11700298]
synonym: "pleated desmosome" RELATED []
is_a: GO:0005918 ! septate junction

[Term]
id: GO:0005920
name: smooth septate junction
namespace: cellular_component
def: "A septate junction that lacks the regular arrays of electron-dense septae found in pleated septate junctions." [PMID:11700298]
synonym: "zonula continua" EXACT []
is_a: GO:0005918 ! septate junction

[Term]
id: GO:0005921
name: gap junction
namespace: cellular_component
def: "A cell-cell junction that is composed of an array of small channels that permit small molecules to pass from one cell to another. At gap junctions, the membranes of two adjacent cells are separated by a uniform narrow gap of about 2-4 nm that is spanned by channel-forming proteins called connexins, which form hexagonal tubes called connexons." [GOC:mah, GOC:mtg_muscle, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_g.html, ISBN:0815332181]
synonym: "communicating junction" EXACT []
synonym: "electrical synapse" RELATED [http:http\://en.wikipedia.org/wiki/Gap_junction]
synonym: "electrotonic synapse" RELATED [NIF_Subcellular:sao1311109124]
synonym: "gap junction macula" EXACT [NIF_Subcellular:sao700839054]
synonym: "gap junction plaque" EXACT [NIF_Subcellular:sao700839054]
synonym: "intercellular gap junction channel" RELATED [NIF_Subcellular:sao-17780464455]
synonym: "macula communicans" EXACT []
synonym: "zonula communicans" EXACT []
xref: NIF_Subcellular:sao118541872
xref: Wikipedia:Gap_junction
is_a: GO:0005911 ! cell-cell junction

[Term]
id: GO:0005922
name: connexon complex
namespace: cellular_component
def: "An assembly of six molecules of connexin, made in the Golgi apparatus and subsequently transported to the plasma membrane, where docking of two connexons on apposed plasma membranes across the extracellular space forms a gap junction." [PMID:11146276]
xref: NIF_Subcellular:sao445019788
is_a: GO:0098797 ! plasma membrane protein complex
relationship: part_of GO:0005921 ! gap junction

[Term]
id: GO:0005923
name: bicellular tight junction
namespace: cellular_component
def: "An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes." [GOC:mah, ISBN:0815332181]
synonym: "zonula occludens" EXACT []
xref: NIF_Subcellular:sao1939999134
xref: Wikipedia:Tight_junction
is_a: GO:0070160 ! occluding junction
relationship: part_of GO:0043296 ! apical junction complex

[Term]
id: GO:0005924
name: cell-substrate adherens junction
namespace: cellular_component
def: "An adherens junction which connects a cell to the extracellular matrix." [GOC:hb]
synonym: "hemi-adherens junction" RELATED []
is_a: GO:0005912 ! adherens junction
is_a: GO:0030055 ! cell-substrate junction

[Term]
id: GO:0005925
name: focal adhesion
namespace: cellular_component
alt_id: GO:0008357
def: "Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments." [ISBN:0124325653, ISBN:0815316208]
synonym: "adhesion plaque" RELATED [PMID:3332661]
synonym: "focal contact" EXACT []
synonym: "hemi-adherens junction" RELATED []
xref: Wikipedia:Focal_adhesion
is_a: GO:0005924 ! cell-substrate adherens junction

[Term]
id: GO:0005926
name: connecting hemi-adherens junction
namespace: cellular_component
def: "A cell-substrate adherens junction, also known as a hemiadherens junction (HAJ) that forms one of a pair of junctions in opposing cells that are separated by only 30-40nm, with a thin line of extracellular electron-dense material in between; found where muscles attach to epidermal cells directly (in insects)." [http://flybase.bio.indiana.edu/allied-data/lk/interactive-fly/aignfam/junction.htm]
is_a: GO:0005924 ! cell-substrate adherens junction

[Term]
id: GO:0005927
name: muscle tendon junction
namespace: cellular_component
def: "A cell-substrate junction found at the terminal anchorage site of skeletal muscle cells to tendons." [GOC:mtg_muscle, PMID:12842007]
synonym: "myotendinous junction" EXACT []
is_a: GO:0005924 ! cell-substrate adherens junction

[Term]
id: GO:0005928
name: apical hemi-adherens junction
namespace: cellular_component
def: "A cell-substrate adherens junction found in the apical region of a cell, such as those found in cuticle-secreting epithelia, which connect the apical membrane to the cuticle." [GOC:mah, PMID:11700298]
synonym: "apical cell-substrate adherens junction" EXACT [GOC:mah]
synonym: "apical dense plaque" EXACT []
is_a: GO:0005924 ! cell-substrate adherens junction

[Term]
id: GO:0005929
name: cilium
namespace: cellular_component
def: "A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:kmv, GOC:vw, ISBN:0198547684]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. In most eukaryotic species, intracellular sub-components of the cilium, such as the ciliary base and rootlet, are located near the plasma membrane. In Diplomonads such as Giardia, instead, the same ciliary parts are located further intracellularly.
subset: goslim_chembl
subset: goslim_generic
subset: goslim_pir
synonym: "eukaryotic flagellum" EXACT []
synonym: "flagellum" RELATED []
synonym: "microtubule-based flagellum" EXACT []
xref: FMA:67181
xref: NIF_Subcellular:sao787716553
xref: Wikipedia:Cilium
is_a: GO:0042995 ! cell projection
is_a: GO:0043226 ! organelle
relationship: has_part GO:0030990 ! intraciliary transport particle

[Term]
id: GO:0005930
name: axoneme
namespace: cellular_component
alt_id: GO:0035085
alt_id: GO:0035086
def: "The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684]
comment: Note that cilia and eukaryotic flagella are deemed to be equivalent. In Diplomonads species such as Giardia, the axoneme may extend intracellularly up to 5um away from the plane of the plasma membrane.
synonym: "ciliary axoneme" EXACT []
synonym: "cilium axoneme" EXACT []
synonym: "flagellar axoneme" EXACT []
synonym: "flagellum axoneme" EXACT []
xref: Wikipedia:Axoneme
is_a: GO:0044441 ! ciliary part
relationship: has_part GO:0005874 ! microtubule
relationship: part_of GO:0097014 ! ciliary plasm

[Term]
id: GO:0005931
name: nexin complex
namespace: cellular_component
def: "A protein complex found in the axoneme of eukaryotic cilia and flagella. It forms interconnections between the microtubule outer doublets that surround the inner central pair of microtubules." [ISBN:0198506732]
is_a: GO:0043234 ! protein complex
is_a: GO:0044447 ! axoneme part

[Term]
id: GO:0005933
name: cellular bud
namespace: cellular_component
def: "A protuberance from a cell of an organism that reproduces by budding, which will grow larger and become a separate daughter cell after nuclear division, cytokinesis, and cell wall formation (when appropriate). The daughter cell may completely separate from the mother cell, or the mother and daughter cells may remain associated." [GOC:sgd_curators]
subset: goslim_candida
subset: goslim_pir
subset: goslim_yeast
is_a: GO:0044464 ! cell part

[Term]
id: GO:0005934
name: cellular bud tip
namespace: cellular_component
def: "The end of a cellular bud distal to the site of attachment to the mother cell." [GOC:mah]
is_a: GO:0030427 ! site of polarized growth
relationship: part_of GO:0005933 ! cellular bud

[Term]
id: GO:0005935
name: cellular bud neck
namespace: cellular_component
def: "The constriction between the mother cell and daughter cell (bud) in an organism that reproduces by budding." [GOC:mah]
is_a: GO:0030427 ! site of polarized growth
relationship: part_of GO:0005933 ! cellular bud

[Term]
id: GO:0005936
name: obsolete shmoo
namespace: cellular_component
def: "OBSOLETE. The characteristic projection formed in response to mating pheromone by cells of Saccharomyces and other fungi with similar life cycles. Named after the Al Capp cartoon character, whose shape it resembles." [GOC:mah, GOC:mcc]
comment: This term was made obsolete because it represents a type of whole cell rather than a cellular component. To update annotations, consider the external ontology term 'shmoo ; FAO:0001023'.
synonym: "shmoo" EXACT []
is_obsolete: true
consider: GO:0001400
consider: GO:0005937

[Term]
id: GO:0005937
name: mating projection
namespace: cellular_component
def: "The projection formed by unicellular fungi in response to mating pheromone." [GOC:mcc]
subset: goslim_pir
synonym: "conjugation tube" NARROW []
synonym: "shmoo" NARROW []
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0005938
name: cell cortex
namespace: cellular_component
def: "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_yeast
synonym: "cell periphery" RELATED []
synonym: "peripheral cytoplasm" RELATED []
xref: Wikipedia:Cell_cortex
is_a: GO:0099568 ! cytoplasmic region
relationship: part_of GO:0071944 ! cell periphery

[Term]
id: GO:0005940
name: septin ring
namespace: cellular_component
alt_id: GO:0030481
def: "A tight ring-shaped structure that forms in the division plane at the site of cytokinesis; composed of members of the conserved family of filament-forming proteins called septins as well as septin-associated proteins. This type of septin structure is observed at the bud neck of budding fungal cells, at the site of cell division in animal cells, at the junction between the mother cell and a pseudohyphal projection, and also within hyphae of filamentous fungi at sites where a septum will form." [GOC:krc, GOC:mah, PMID:16009555, PMID:16151244]
xref: Wikipedia:Septin_ring
is_a: GO:0032156 ! septin cytoskeleton
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044448 ! cell cortex part

[Term]
id: GO:0005941
name: obsolete unlocalized protein complex
namespace: cellular_component
def: "OBSOLETE. Used as a holding place for cellular components whose precise localization is, as yet, unknown, or has not been determined by GO (the latter is the major reason for nodes to have this parent); this term should not be used for annotation of gene products." [GOC:ma]
comment: This term was made obsolete because it was originally intended only as a temporary parent for protein complex terms for which no more specific parents had been found. This term no longer has any children: All protein complex terms are is_a 'protein complex ; GO:0043234' and nearly all have been placed under parents to yield more specific paths traversing a part_of relationship. In other words, the term has been superseded by other terms and relationships in the cellular component ontology, and is no longer needed.
synonym: "unlocalized protein complex" EXACT []
is_obsolete: true

[Term]
id: GO:0005942
name: phosphatidylinositol 3-kinase complex
namespace: cellular_component
def: "A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too." [GOC:bf, PMID:24587488]
comment: For discussion of membrane association, please see https://sourceforge.net/p/geneontology/ontology-requests/11559/
subset: goslim_pir
synonym: "1-phosphatidylinositol 3-kinase complex" EXACT []
synonym: "phosphoinositide 3-kinase complex" EXACT [GOC:curators]
synonym: "PI3-kinase p85-subunit alpha- PI3-kinase p110 complex" NARROW [CORUM:2575]
synonym: "PI3K complex" EXACT []
synonym: "PIK3C3-PIK3R4 complex" NARROW [CORUM:429]
synonym: "PIK3CA-PIK3R1 complex" NARROW [CORUM:439]
is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0019898 ! extrinsic component of membrane

[Term]
id: GO:0005943
name: phosphatidylinositol 3-kinase complex, class IA
namespace: cellular_component
alt_id: GO:0035030
def: "A class I phosphatidylinositol 3-kinase complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic class IA phosphoinositide 3-kinase (PI3K) subunit and an associated SH2 domain-containing regulatory subunit that is a member of a family of related proteins often called p85 proteins. Through the interaction with the SH2-containing adaptor subunits, Class IA PI3K catalytic subunits are linked to tyrosine kinase signaling pathways." [PMID:9255069, PMID:9759495]
synonym: "1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex" EXACT []
synonym: "1-phosphatidylinositol-4-phosphate kinase, class IA complex" EXACT []
synonym: "class IA PI3K complex" EXACT []
synonym: "phosphoinositide 3-kinase complex, class IA" EXACT []
is_a: GO:0097651 ! phosphatidylinositol 3-kinase complex, class I

[Term]
id: GO:0005944
name: phosphatidylinositol 3-kinase complex, class IB
namespace: cellular_component
alt_id: GO:0035031
def: "A class I phosphatidylinositol 3-kinase complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic class IB phosphoinositide 3-kinase (PI3K) subunit and an associated regulatory subunit that is larger than, and unrelated to, the p85 proteins present in class IA complexes. Class IB PI3Ks are stimulated by G-proteins and do not interact with the SH2-domain containing adaptors that bind to Class IA PI3Ks." [PMID:9255069, PMID:9759495]
synonym: "1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex" EXACT []
synonym: "1-phosphatidylinositol-4-phosphate kinase, class IB complex" RELATED []
synonym: "class IB PI3K complex" EXACT []
synonym: "phosphoinositide 3-kinase complex, class IB" EXACT []
is_a: GO:0097651 ! phosphatidylinositol 3-kinase complex, class I

[Term]
id: GO:0005945
name: 6-phosphofructokinase complex
namespace: cellular_component
def: "A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known." [GOC:mah, GOC:vw, ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0044445 ! cytosolic part
is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups

[Term]
id: GO:0005946
name: alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
namespace: cellular_component
def: "A protein complex that possesses alpha,alpha-trehalose-phosphate synthase (UDP-forming) and trehalose-phosphatase activities, and thus catalyzes two reactions in trehalose biosynthesis. In the complex identified in Saccharomyces, Tps1p has alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity, Tps2p has trehalose 6-phosphate phosphatase activity; Tps3p is a regulatory subunit, and an additional subunit, Tsl1p, may be present." [PMID:9837904]
comment: See also the molecular function term 'alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity ; GO:0003825'.
synonym: "trehalose-6-phosphate synthase complex" EXACT []
synonym: "trehalose-6-phosphate synthase/phosphatase" EXACT []
synonym: "UDP-glucose-glucosephosphate glucosyltransferase complex" EXACT []
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:1990234 ! transferase complex

[Term]
id: GO:0005947
name: mitochondrial alpha-ketoglutarate dehydrogenase complex
namespace: cellular_component
def: "Mitochondrial complex that possesses alpha-ketoglutarate dehydrogenase activity." [GOC:mah, GOC:mtg_sensu]
synonym: "2-oxoglutarate dehydrogenase complex" BROAD []
is_a: GO:0030062 ! mitochondrial tricarboxylic acid cycle enzyme complex
is_a: GO:0045240 ! dihydrolipoyl dehydrogenase complex
intersection_of: GO:0045240 ! dihydrolipoyl dehydrogenase complex
intersection_of: part_of GO:0005739 ! mitochondrion
relationship: part_of GO:0005739 ! mitochondrion

[Term]
id: GO:0005948
name: acetolactate synthase complex
namespace: cellular_component
def: "A dimeric (a large and a small chain) or tetrameric (two large and two small chains) enzyme complex. Catalyzes the formation of acetolactate from pyruvate." [BRENDA:2.2.1.6, GOC:jl, PMID:16458324, PMID:8756689]
comment: See also the molecular function term 'acetolactate synthase activity ; GO:0003984'.
subset: gosubset_prok
synonym: "acetohydroxyacid synthase complex" EXACT []
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:1990234 ! transferase complex

[Term]
id: GO:0005949
name: obsolete aminoadipate-semialdehyde dehydrogenase complex
namespace: cellular_component
def: "OBSOLETE. A heterodimeric enzyme composed of an alpha and beta subunit. Catalyzes the formation of L-2-aminoadipate from L-2-aminoadipate 6-semialdehyde." [EC:1.2.1.31]
comment: This term was made obsolete because the catalytic activity resides in a single polypeptide that is not part of a complex with other gene products.
synonym: "aminoadipate-semialdehyde dehydrogenase complex" EXACT []
is_obsolete: true

[Term]
id: GO:0005950
name: anthranilate synthase complex
namespace: cellular_component
def: "A heterotetrameric enzyme complex made up of two components I and two components II. Catalyzes the formation of anthranilate, pyruvate and L-glutamate from chorismate and L-glutamine." [EC:4.1.3.27, MetaCyc:ANTHRANSYN-CPLX, PMID:4886290]
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0005951
name: carbamoyl-phosphate synthase complex
namespace: cellular_component
def: "A protein complex that catalyzes the formation of carbamoyl phosphate; comprises a small subunit that binds and cleaves glutamine, and a large subunit that accepts the ammonia group cleaved from glutamine, binds all of the remaining substrates and effectors, and carries out all of the other catalytic events." [PMID:8626695]
comment: Note that in higher eukaryotes, carbamoyl-phosphate synthase is usually a single polypeptide, not a complex, and should therefore not be annotated to this component term.
subset: gosubset_prok
synonym: "arginine-specific carbamoyl phosphate synthetase complex" NARROW []
synonym: "carbamoyl phosphate synthase complex" EXACT []
synonym: "carbamoyl-phosphate synthase arginine-specific complex" NARROW []
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0005952
name: cAMP-dependent protein kinase complex
namespace: cellular_component
def: "An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer." [EC:2.7.11.11, ISBN:0198506732]
subset: gosubset_prok
synonym: "3',5' cAMP-dependent protein kinase complex" EXACT []
synonym: "3',5'-cAMP-dependent protein kinase complex" EXACT []
synonym: "adenosine 3',5'-cyclophosphate-dependent protein kinase complex" EXACT []
synonym: "cyclic AMP-dependent protein kinase complex" EXACT []
synonym: "PKA" RELATED []
is_a: GO:0044424 ! intracellular part
is_a: GO:1902554 ! serine/threonine protein kinase complex

[Term]
id: GO:0005953
name: CAAX-protein geranylgeranyltransferase complex
namespace: cellular_component
def: "A heterodimeric enzyme, composed of an alpha and a beta subunit. Participates in the post-translational C-terminal modification of several small GTPases, allowing their targeting to the membrane." [PMID:9781874]
is_a: GO:0044424 ! intracellular part
is_a: GO:1990234 ! transferase complex

[Term]
id: GO:0005954
name: calcium- and calmodulin-dependent protein kinase complex
namespace: cellular_component
def: "An enzyme complex which in eukaryotes is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Catalyzes the phosphorylation of proteins to O-phosphoproteins." [EC:2.7.11.17]
synonym: "calcium/calmodulin-dependent protein kinase complex" EXACT []
synonym: "CAMK2" EXACT []
synonym: "CaMKII" RELATED []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0005955
name: calcineurin complex
namespace: cellular_component
def: "A heterodimeric calcium ion and calmodulin dependent protein phosphatase composed of catalytic and regulatory subunits; the regulatory subunit is very similar in sequence to calmodulin." [ISBN:019859951]
synonym: "calcium-dependent protein serine/threonine phosphatase complex" NARROW []
synonym: "protein phosphatase type 2B complex" EXACT []
is_a: GO:0008287 ! protein serine/threonine phosphatase complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0005956
name: protein kinase CK2 complex
namespace: cellular_component
def: "A protein complex that possesses protein serine/threonine kinase activity, and contains two catalytic alpha subunits and two regulatory beta subunits. Protein kinase CK2 complexes are found in nearly every subcellular compartment, and can phosphorylate many protein substrates in addition to casein." [GOC:mah, PMID:10994779]
comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex.
synonym: "casein kinase II complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0005957
name: obsolete debranching enzyme
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it is ambiguous (there are several debranching enzymes) and because it probably represents the glycogen debranching enzyme which is a single gene product and not a complex.
synonym: "debranching enzyme" EXACT []
is_obsolete: true
consider: GO:0043033

[Term]
id: GO:0005958
name: DNA-dependent protein kinase-DNA ligase 4 complex
namespace: cellular_component
alt_id: GO:0005959
def: "A large protein complex which is involved in the repair of DNA double-strand breaks and, in mammals, V(D)J recombination events. It consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs), the DNA end-binding heterodimer Ku, the nuclear phosphoprotein XRCC4 or a homolog thereof, and DNA ligase IV." [GOC:jl, GOC:mah, PMID:10854421, PMID:12235392, PMID:17072889]
is_a: GO:0044428 ! nuclear part
is_a: GO:0070419 ! nonhomologous end joining complex

[Term]
id: GO:0005960
name: glycine cleavage complex
namespace: cellular_component
alt_id: GO:0005961
alt_id: GO:0070015
def: "A protein complex that catalyzes the reversible oxidation of glycine. In E. coli, it has four components: dihydrolipoamide dehydrogenase, glycine dehydrogenase (decarboxylating), lipoyl-GcvH-protein and aminomethyltransferase, also known as L, P, H, and T." [GOC:mah, MetaCyc:GCVMULTI-CPLX]
subset: goslim_pir
subset: gosubset_prok
synonym: "glycine cleavage system" EXACT []
synonym: "glycine decarboxylase complex" EXACT []
synonym: "glycine dehydrogenase (decarboxylating) complex" EXACT []
synonym: "glycine dehydrogenase complex (decarboxylating)" RELATED []
synonym: "glycine synthase complex" EXACT []
xref: Wikipedia:Glycine_decarboxylase_complex
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:0005962
name: mitochondrial isocitrate dehydrogenase complex (NAD+)
namespace: cellular_component
def: "Mitochondrial complex that possesses isocitrate dehydrogenase (NAD+) activity." [GOC:mah, GOC:mtg_sensu]
comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function of this complex is represented by the molecular function term 'isocitrate dehydrogenase (NAD+) activity ; GO:0004449'.
is_a: GO:0030062 ! mitochondrial tricarboxylic acid cycle enzyme complex
is_a: GO:0045242 ! isocitrate dehydrogenase complex (NAD+)
intersection_of: GO:0045242 ! isocitrate dehydrogenase complex (NAD+)
intersection_of: part_of GO:0005739 ! mitochondrion
relationship: part_of GO:0005739 ! mitochondrion

[Term]
id: GO:0005963
name: magnesium-dependent protein serine/threonine phosphatase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the removal of serine- or threonine-bound phosphate groups from a wide range of phosphoproteins, including a number of enzymes that have been phosphorylated under the action of a kinase." [EC:3.1.3.16]
is_a: GO:0008287 ! protein serine/threonine phosphatase complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0005964
name: phosphorylase kinase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a." [EC:2.7.11.19]
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:1902554 ! serine/threonine protein kinase complex

[Term]
id: GO:0005965
name: protein farnesyltransferase complex
namespace: cellular_component
def: "A protein complex that possesses protein farnesyltransferase activity." [GOC:mah]
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:1990234 ! transferase complex

[Term]
id: GO:0005966
name: cyclic-nucleotide phosphodiesterase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the hydrolysis of bonds in a cyclic nucleotide." [EC:3.1.4.-]
synonym: "photoreceptor cyclic-nucleotide phosphodiesterase complex" NARROW []
is_a: GO:0044464 ! cell part
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0005967
name: mitochondrial pyruvate dehydrogenase complex
namespace: cellular_component
def: "Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA in eukaryotes; includes subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). The This Eukaryotic form usually contains more subunits than its bacterial counterpart; for example, one known complex contains 30 E1 dimers, 60 E2 monomers, and 6 E3 dimers as well as a few copies of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase." [GOC:mtg_sensu, ISBN:0471331309, ISBN:0716720094]
comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The functions of this complex are represented by the molecular function terms 'pyruvate dehydrogenase (lipoamide) activity ; GO:0004739', 'dihydrolipoamide S-acetyltransferase activity ; GO:0004742', and 'dihydrolipoamide dehydrogenase activity ; GO:0004148'.
synonym: "pyruvate dehydrogenase complex (lipoamide)" BROAD []
is_a: GO:0045254 ! pyruvate dehydrogenase complex
is_a: GO:0098798 ! mitochondrial protein complex
intersection_of: GO:0045254 ! pyruvate dehydrogenase complex
intersection_of: part_of GO:0005739 ! mitochondrion
relationship: part_of GO:0005739 ! mitochondrion
relationship: part_of GO:0005759 ! mitochondrial matrix

[Term]
id: GO:0005968
name: Rab-protein geranylgeranyltransferase complex
namespace: cellular_component
def: "A heterodimeric enzyme complex, which in mammals is composed of an alpha and a beta subunit, and which associates with an accessory protein Rep (Rab escort protein). Catalyzes of the transfer of a geranyl-geranyl group from geranylgeranyl pyrophosphate to a Rab protein." [GOC:jl, PMID:11886217]
synonym: "GGTase-II complex" EXACT []
synonym: "Rab geranylgeranyltransferase complex" EXACT []
synonym: "RAB-protein geranylgeranyltransferase complex" EXACT []
synonym: "RabGGTase complex" EXACT []
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:1990234 ! transferase complex

[Term]
id: GO:0005969
name: serine-pyruvate aminotransferase complex
namespace: cellular_component
alt_id: GO:0005970
def: "An enzyme complex that catalyzes the formation of hydroxypyruvate and alanine from serine and pyruvate." [EC:2.6.1.51]
synonym: "serine-pyruvate aminotransferase, type 1 complex" NARROW []
synonym: "serine-pyruvate aminotransferase, type 2B complex" NARROW []
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:1990234 ! transferase complex

[Term]
id: GO:0005971
name: ribonucleoside-diphosphate reductase complex
namespace: cellular_component
def: "An enzyme complex composed of 2-4 or more subunits, which usually contains nonheme iron and requires ATP for catalysis. Catalyzes the formation of 2'-deoxyribonucleoside diphosphate from ribonucleoside diphosphate, using either thioredoxin disulfide or glutaredoxin disulfide as an acceptor." [BRENDA:1.17.4.1]
subset: gosubset_prok
synonym: "ribonucleotide reductase complex" EXACT [GOC:mah]
synonym: "RNR complex" EXACT [GOC:mah]
is_a: GO:0044445 ! cytosolic part
is_a: GO:1990204 ! oxidoreductase complex
relationship: part_of GO:0005829 ! cytosol

[Term]
id: GO:0005972
name: obsolete fibrinogen alpha chain
namespace: cellular_component
alt_id: GO:0008005
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "fibrinogen alpha chain" EXACT []
is_obsolete: true
consider: GO:0005577

[Term]
id: GO:0005973
name: obsolete fibrinogen beta chain
namespace: cellular_component
alt_id: GO:0008006
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "fibrinogen beta chain" EXACT []
is_obsolete: true
consider: GO:0005577

[Term]
id: GO:0005974
name: obsolete fibrinogen gamma chain
namespace: cellular_component
alt_id: GO:0008007
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "fibrinogen gamma chain" EXACT []
is_obsolete: true
consider: GO:0005577

[Term]
id: GO:0005975
name: carbohydrate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "carbohydrate metabolism" EXACT []
xref: Reactome:REACT_102834 "Metabolism of carbohydrates, Mus musculus"
xref: Reactome:REACT_103806 "Metabolism of carbohydrates, Mycobacterium tuberculosis"
xref: Reactome:REACT_104502 "Metabolism of carbohydrates, Gallus gallus"
xref: Reactome:REACT_105321 "Metabolism of carbohydrates, Escherichia coli"
xref: Reactome:REACT_106046 "Metabolism of carbohydrates, Drosophila melanogaster"
xref: Reactome:REACT_107409 "Metabolism of carbohydrates, Caenorhabditis elegans"
xref: Reactome:REACT_115733 "Carbohydrate metabolism, Gallus gallus"
xref: Reactome:REACT_28218 "Metabolism of carbohydrates, Xenopus tropicalis"
xref: Reactome:REACT_32291 "Metabolism of carbohydrates, Staphylococcus aureus N315"
xref: Reactome:REACT_33141 "Metabolism of carbohydrates, Taeniopygia guttata"
xref: Reactome:REACT_33953 "Metabolism of carbohydrates, Rattus norvegicus"
xref: Reactome:REACT_34800 "Metabolism of carbohydrates, Danio rerio"
xref: Reactome:REACT_474 "Metabolism of carbohydrates, Homo sapiens"
xref: Reactome:REACT_77669 "Metabolism of carbohydrates, Plasmodium falciparum"
xref: Reactome:REACT_81945 "Metabolism of carbohydrates, Schizosaccharomyces pombe"
xref: Reactome:REACT_83038 "Metabolism of carbohydrates, Arabidopsis thaliana"
xref: Reactome:REACT_83329 "Metabolism of carbohydrates, Saccharomyces cerevisiae"
xref: Reactome:REACT_88330 "Metabolism of carbohydrates, Bos taurus"
xref: Reactome:REACT_88558 "Metabolism of carbohydrates, Canis familiaris"
xref: Reactome:REACT_90099 "Metabolism of carbohydrates, Sus scrofa"
xref: Reactome:REACT_96375 "Metabolism of carbohydrates, Dictyostelium discoideum"
xref: Reactome:REACT_98394 "Metabolism of carbohydrates, Oryza sativa"
xref: Wikipedia:Carbohydrate_metabolism
is_a: GO:0044238 ! primary metabolic process
is_a: GO:0071704 ! organic substance metabolic process

[Term]
id: GO:0005976
name: polysaccharide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [CHEBI:18154, ISBN:0198547684]
subset: goslim_pir
subset: gosubset_prok
synonym: "glycan metabolic process" EXACT []
synonym: "glycan metabolism" EXACT []
synonym: "polysaccharide metabolism" EXACT []
is_a: GO:0005975 ! carbohydrate metabolic process
is_a: GO:0043170 ! macromolecule metabolic process

[Term]
id: GO:0005977
name: glycogen metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages." [ISBN:0198506732]
subset: gosubset_prok
synonym: "glycogen metabolism" EXACT []
is_a: GO:0006073 ! cellular glucan metabolic process
is_a: GO:0006112 ! energy reserve metabolic process
is_a: GO:0044723 ! single-organism carbohydrate metabolic process

[Term]
id: GO:0005978
name: glycogen biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." [ISBN:0198506732]
subset: gosubset_prok
synonym: "glycogen anabolism" EXACT []
synonym: "glycogen biosynthesis" EXACT []
synonym: "glycogen formation" EXACT []
synonym: "glycogen synthesis" EXACT []
xref: MetaCyc:GLYCOGENSYNTH-PWY
xref: Reactome:REACT_100165 "Glycogen synthesis, Schizosaccharomyces pombe"
xref: Reactome:REACT_100210 "Glycogen synthesis, Oryza sativa"
xref: Reactome:REACT_104809 "Glycogen synthesis, Bos taurus"
xref: Reactome:REACT_106066 "Glycogen synthesis, Saccharomyces cerevisiae"
xref: Reactome:REACT_108178 "Glycogen synthesis, Mycobacterium tuberculosis"
xref: Reactome:REACT_109803 "Glycogen synthesis, Drosophila melanogaster"
xref: Reactome:REACT_110636 "Glycogen synthesis, Dictyostelium discoideum"
xref: Reactome:REACT_1736 "Glycogen synthesis, Homo sapiens"
xref: Reactome:REACT_31318 "Glycogen synthesis, Taeniopygia guttata"
xref: Reactome:REACT_78660 "Glycogen synthesis, Xenopus tropicalis"
xref: Reactome:REACT_78900 "Glycogen synthesis, Sus scrofa"
xref: Reactome:REACT_84301 "Glycogen synthesis, Escherichia coli"
xref: Reactome:REACT_85173 "Glycogen synthesis, Danio rerio"
xref: Reactome:REACT_85550 "Glycogen synthesis, Canis familiaris"
xref: Reactome:REACT_89393 "Glycogen synthesis, Plasmodium falciparum"
xref: Reactome:REACT_89736 "Glycogen synthesis, Arabidopsis thaliana"
xref: Reactome:REACT_89993 "Glycogen synthesis, Gallus gallus"
xref: Reactome:REACT_92986 "Glycogen synthesis, Mus musculus"
xref: Reactome:REACT_98375 "Glycogen synthesis, Rattus norvegicus"
xref: Reactome:REACT_98834 "Glycogen synthesis, Caenorhabditis elegans"
is_a: GO:0005977 ! glycogen metabolic process
is_a: GO:0009250 ! glucan biosynthetic process

[Term]
id: GO:0005979
name: regulation of glycogen biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of glycogen anabolism" EXACT []
synonym: "regulation of glycogen biosynthesis" EXACT []
synonym: "regulation of glycogen formation" EXACT []
synonym: "regulation of glycogen synthesis" EXACT []
is_a: GO:0010962 ! regulation of glucan biosynthetic process
is_a: GO:0070873 ! regulation of glycogen metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0005978 ! glycogen biosynthetic process
relationship: regulates GO:0005978 ! glycogen biosynthetic process

[Term]
id: GO:0005980
name: glycogen catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." [ISBN:0198506732]
subset: gosubset_prok
synonym: "glycogen breakdown" EXACT []
synonym: "glycogen catabolism" EXACT []
synonym: "glycogen degradation" EXACT []
synonym: "glycogenolysis" EXACT [GOC:sl]
xref: MetaCyc:GLYCOCAT-PWY
xref: Reactome:REACT_100299 "Glycogen breakdown (glycogenolysis), Xenopus tropicalis"
xref: Reactome:REACT_1008 "Glycogen breakdown (glycogenolysis), Homo sapiens"
xref: Reactome:REACT_101354 "Glycogen breakdown (glycogenolysis), Mus musculus"
xref: Reactome:REACT_103941 "Glycogen breakdown (glycogenolysis), Caenorhabditis elegans"
xref: Reactome:REACT_104576 "Glycogen breakdown (glycogenolysis), Gallus gallus"
xref: Reactome:REACT_105183 "Glycogen breakdown (glycogenolysis), Taeniopygia guttata"
xref: Reactome:REACT_108340 "Glycogen breakdown (glycogenolysis), Oryza sativa"
xref: Reactome:REACT_28308 "Glycogen breakdown (glycogenolysis), Mycobacterium tuberculosis"
xref: Reactome:REACT_34093 "Glycogen breakdown (glycogenolysis), Bos taurus"
xref: Reactome:REACT_69254 "Glycogen breakdown (glycogenolysis), Schizosaccharomyces pombe"
xref: Reactome:REACT_77071 "Glycogen breakdown (glycogenolysis), Saccharomyces cerevisiae"
xref: Reactome:REACT_79214 "Glycogen breakdown (glycogenolysis), Sus scrofa"
xref: Reactome:REACT_80237 "Glycogen breakdown (glycogenolysis), Rattus norvegicus"
xref: Reactome:REACT_84145 "Glycogen breakdown (glycogenolysis), Escherichia coli"
xref: Reactome:REACT_84570 "Glycogen breakdown (glycogenolysis), Canis familiaris"
xref: Reactome:REACT_86743 "Glycogen breakdown (glycogenolysis), Arabidopsis thaliana"
xref: Reactome:REACT_87579 "Glycogen breakdown (glycogenolysis), Plasmodium falciparum"
xref: Reactome:REACT_88320 "Glycogen breakdown (glycogenolysis), Dictyostelium discoideum"
xref: Reactome:REACT_94776 "Glycogen breakdown (glycogenolysis), Danio rerio"
xref: Reactome:REACT_95658 "Glycogen breakdown (glycogenolysis), Drosophila melanogaster"
is_a: GO:0005977 ! glycogen metabolic process
is_a: GO:0009251 ! glucan catabolic process
is_a: GO:0044247 ! cellular polysaccharide catabolic process
is_a: GO:0044724 ! single-organism carbohydrate catabolic process

[Term]
id: GO:0005981
name: regulation of glycogen catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of glycogen breakdown" EXACT []
synonym: "regulation of glycogen catabolism" EXACT []
synonym: "regulation of glycogen degradation" EXACT []
synonym: "regulation of glycogenolysis" EXACT [GOC:sl]
is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process
is_a: GO:0070873 ! regulation of glycogen metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0005980 ! glycogen catabolic process
relationship: regulates GO:0005980 ! glycogen catabolic process

[Term]
id: GO:0005982
name: starch metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving starch, the most important reserve polysaccharide in plants. It is a glucan consisting of two components, amylose and amylopectin, which are both glucose homopolymers. Starch is synthesized as a temporary storage form of carbon and can be catabolized to produce sucrose." [ISBN:0198506732]
subset: gosubset_prok
synonym: "starch metabolism" EXACT []
is_a: GO:0006073 ! cellular glucan metabolic process

[Term]
id: GO:0005983
name: starch catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of starch, the most important reserve polysaccharide in plants." [GOC:ai]
subset: gosubset_prok
synonym: "starch breakdown" EXACT []
synonym: "starch catabolism" EXACT []
synonym: "starch degradation" EXACT []
xref: MetaCyc:PWY-842
is_a: GO:0005982 ! starch metabolic process
is_a: GO:0009251 ! glucan catabolic process
is_a: GO:0044247 ! cellular polysaccharide catabolic process

[Term]
id: GO:0005984
name: disaccharide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any disaccharide, sugars composed of two monosaccharide units." [GOC:jl, ISBN:01928006X]
subset: gosubset_prok
synonym: "disaccharide metabolism" EXACT []
is_a: GO:0009311 ! oligosaccharide metabolic process
is_a: GO:0044262 ! cellular carbohydrate metabolic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0005985
name: sucrose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sucrose, the disaccharide fructofuranosyl-glucopyranoside." [GOC:go_curators]
subset: gosubset_prok
synonym: "sucrose metabolism" EXACT []
is_a: GO:0005984 ! disaccharide metabolic process

[Term]
id: GO:0005986
name: sucrose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sucrose, the disaccharide fructofuranosyl-glucopyranoside." [GOC:go_curators]
subset: gosubset_prok
synonym: "sucrose anabolism" EXACT []
synonym: "sucrose biosynthesis" EXACT []
synonym: "sucrose formation" EXACT []
synonym: "sucrose synthesis" EXACT []
xref: MetaCyc:SUCSYN-PWY
is_a: GO:0005985 ! sucrose metabolic process
is_a: GO:0046351 ! disaccharide biosynthetic process

[Term]
id: GO:0005987
name: sucrose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of sucrose, the disaccharide fructofuranosyl-glucopyranoside." [GOC:go_curators]
subset: gosubset_prok
synonym: "sucrose breakdown" EXACT []
synonym: "sucrose catabolism" EXACT []
synonym: "sucrose degradation" EXACT []
is_a: GO:0005985 ! sucrose metabolic process
is_a: GO:0046352 ! disaccharide catabolic process

[Term]
id: GO:0005988
name: lactose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lactose, the disaccharide galactopyranosyl-glucose." [GOC:go_curators]
subset: gosubset_prok
synonym: "lactose metabolism" EXACT []
is_a: GO:0005984 ! disaccharide metabolic process

[Term]
id: GO:0005989
name: lactose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lactose, the disaccharide galactopyranosyl-glucose." [GOC:go_curators]
subset: gosubset_prok
synonym: "lactose anabolism" EXACT []
synonym: "lactose biosynthesis" EXACT []
synonym: "lactose formation" EXACT []
synonym: "lactose synthesis" EXACT []
is_a: GO:0005988 ! lactose metabolic process
is_a: GO:0046351 ! disaccharide biosynthetic process

[Term]
id: GO:0005990
name: lactose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lactose, the disaccharide galactopyranosyl-glucose." [GOC:go_curators]
subset: gosubset_prok
synonym: "lactose breakdown" EXACT []
synonym: "lactose catabolism" EXACT []
synonym: "lactose degradation" EXACT []
is_a: GO:0005988 ! lactose metabolic process
is_a: GO:0046352 ! disaccharide catabolic process

[Term]
id: GO:0005991
name: trehalose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:jl, ISBN:0028623819]
subset: gosubset_prok
synonym: "mycose metabolic process" EXACT []
synonym: "mycose metabolism" EXACT []
synonym: "mykose metabolic process" EXACT []
synonym: "mykose metabolism" EXACT []
synonym: "trehalose metabolism" EXACT []
is_a: GO:0005984 ! disaccharide metabolic process

[Term]
id: GO:0005992
name: trehalose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:jl, ISBN:0028623819]
subset: gosubset_prok
synonym: "mycose biosynthesis" EXACT []
synonym: "mycose biosynthetic process" EXACT []
synonym: "mykose biosynthesis" EXACT []
synonym: "mykose biosynthetic process" EXACT []
synonym: "trehalose anabolism" EXACT []
synonym: "trehalose biosynthesis" EXACT []
synonym: "trehalose formation" EXACT []
synonym: "trehalose synthesis" EXACT []
xref: MetaCyc:PWY-881
xref: MetaCyc:TREHALOSESYN-PWY
xref: MetaCyc:TRESYN-PWY
xref: Reactome:REACT_27232 "Trehalose biosynthesis, Mycobacterium tuberculosis"
is_a: GO:0005991 ! trehalose metabolic process
is_a: GO:0046351 ! disaccharide biosynthetic process

[Term]
id: GO:0005993
name: trehalose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:jl, ISBN:0028623819]
subset: gosubset_prok
synonym: "mycose catabolic process" EXACT []
synonym: "mycose catabolism" EXACT []
synonym: "mykose catabolic process" EXACT []
synonym: "mykose catabolism" EXACT []
synonym: "trehalose breakdown" EXACT []
synonym: "trehalose catabolism" EXACT []
synonym: "trehalose degradation" EXACT []
xref: MetaCyc:TREDEGLOW-PWY
is_a: GO:0005991 ! trehalose metabolic process
is_a: GO:0046352 ! disaccharide catabolic process

[Term]
id: GO:0005994
name: melibiose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving melibiose, the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose." [ISBN:0198547684]
subset: gosubset_prok
synonym: "melibiose metabolism" EXACT []
is_a: GO:0005984 ! disaccharide metabolic process

[Term]
id: GO:0005995
name: melibiose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of melibiose, the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose." [ISBN:0198547684]
subset: gosubset_prok
synonym: "melibiose breakdown" EXACT []
synonym: "melibiose catabolism" EXACT []
synonym: "melibiose degradation" EXACT []
is_a: GO:0005994 ! melibiose metabolic process
is_a: GO:0046352 ! disaccharide catabolic process

[Term]
id: GO:0005996
name: monosaccharide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [ISBN:0198506732]
subset: gosubset_prok
synonym: "monosaccharide metabolism" EXACT []
is_a: GO:0044281 ! small molecule metabolic process
is_a: GO:0044723 ! single-organism carbohydrate metabolic process

[Term]
id: GO:0005997
name: xylulose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving xylulose, the ketopentose threo-2-pentulose." [ISBN:0198547684]
subset: gosubset_prok
synonym: "xylulose metabolism" EXACT []
is_a: GO:0019321 ! pentose metabolic process

[Term]
id: GO:0005998
name: xylulose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of xylulose, the ketopentose threo-2-pentulose." [ISBN:0198547684]
subset: gosubset_prok
synonym: "xylulose breakdown" EXACT []
synonym: "xylulose catabolism" EXACT []
synonym: "xylulose degradation" EXACT []
xref: MetaCyc:XYLCAT-PWY
is_a: GO:0005997 ! xylulose metabolic process
is_a: GO:0019323 ! pentose catabolic process

[Term]
id: GO:0005999
name: xylulose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of xylulose, the ketopentose threo-2-pentulose." [ISBN:0198547684]
subset: gosubset_prok
synonym: "xylulose anabolism" EXACT []
synonym: "xylulose biosynthesis" EXACT []
synonym: "xylulose formation" EXACT []
synonym: "xylulose synthesis" EXACT []
xref: Reactome:REACT_100985 "Insulin effects increased synthesis of Xylulose-5-Phosphate, Mus musculus"
xref: Reactome:REACT_101007 "Insulin effects increased synthesis of Xylulose-5-Phosphate, Arabidopsis thaliana"
xref: Reactome:REACT_101992 "Insulin effects increased synthesis of Xylulose-5-Phosphate, Gallus gallus"
xref: Reactome:REACT_102846 "Insulin effects increased synthesis of Xylulose-5-Phosphate, Canis familiaris"
xref: Reactome:REACT_105252 "Insulin effects increased synthesis of Xylulose-5-Phosphate, Sus scrofa"
xref: Reactome:REACT_105448 "Insulin effects increased synthesis of Xylulose-5-Phosphate, Taeniopygia guttata"
xref: Reactome:REACT_106544 "Insulin effects increased synthesis of Xylulose-5-Phosphate, Rattus norvegicus"
xref: Reactome:REACT_106873 "Insulin effects increased synthesis of Xylulose-5-Phosphate, Drosophila melanogaster"
xref: Reactome:REACT_109893 "Insulin effects increased synthesis of Xylulose-5-Phosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_28527 "Insulin effects increased synthesis of Xylulose-5-Phosphate, Dictyostelium discoideum"
xref: Reactome:REACT_28902 "Insulin effects increased synthesis of Xylulose-5-Phosphate, Bos taurus"
xref: Reactome:REACT_34109 "Insulin effects increased synthesis of Xylulose-5-Phosphate, Caenorhabditis elegans"
xref: Reactome:REACT_78767 "Insulin effects increased synthesis of Xylulose-5-Phosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_80764 "Insulin effects increased synthesis of Xylulose-5-Phosphate, Xenopus tropicalis"
xref: Reactome:REACT_81035 "Insulin effects increased synthesis of Xylulose-5-Phosphate, Oryza sativa"
xref: Reactome:REACT_82366 "Insulin effects increased synthesis of Xylulose-5-Phosphate, Escherichia coli"
xref: Reactome:REACT_88035 "Insulin effects increased synthesis of Xylulose-5-Phosphate, Danio rerio"
xref: Reactome:REACT_939 "Insulin effects increased synthesis of Xylulose-5-Phosphate, Homo sapiens"
is_a: GO:0005997 ! xylulose metabolic process
is_a: GO:0019322 ! pentose biosynthetic process

[Term]
id: GO:0006000
name: fructose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey." [ISBN:0198506732]
subset: gosubset_prok
synonym: "fructose metabolism" EXACT []
xref: Wikipedia:Fructose
is_a: GO:0019318 ! hexose metabolic process

[Term]
id: GO:0006001
name: fructose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of fructose, the ketohexose arabino-2-hexulose." [GOC:ai]
subset: gosubset_prok
synonym: "fructose breakdown" EXACT []
synonym: "fructose catabolism" EXACT []
synonym: "fructose degradation" EXACT []
xref: Reactome:REACT_100892 "Fructose catabolism, Gallus gallus"
xref: Reactome:REACT_102174 "Fructose catabolism, Mus musculus"
xref: Reactome:REACT_108574 "Fructose catabolism, Dictyostelium discoideum"
xref: Reactome:REACT_110728 "Fructose catabolism, Oryza sativa"
xref: Reactome:REACT_1571 "Fructose catabolism, Homo sapiens"
xref: Reactome:REACT_30000 "Fructose catabolism, Rattus norvegicus"
xref: Reactome:REACT_34103 "Fructose catabolism, Drosophila melanogaster"
xref: Reactome:REACT_34752 "Fructose catabolism, Arabidopsis thaliana"
xref: Reactome:REACT_80249 "Fructose catabolism, Xenopus tropicalis"
xref: Reactome:REACT_81101 "Fructose catabolism, Canis familiaris"
xref: Reactome:REACT_83322 "Fructose catabolism, Plasmodium falciparum"
xref: Reactome:REACT_91064 "Fructose catabolism, Danio rerio"
xref: Reactome:REACT_92021 "Fructose catabolism, Taeniopygia guttata"
xref: Reactome:REACT_94187 "Fructose catabolism, Sus scrofa"
xref: Reactome:REACT_94513 "Fructose catabolism, Bos taurus"
xref: Reactome:REACT_98970 "Fructose catabolism, Caenorhabditis elegans"
is_a: GO:0006000 ! fructose metabolic process
is_a: GO:0019320 ! hexose catabolic process

[Term]
id: GO:0006002
name: fructose 6-phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fructose 6-phosphate, also known as F6P. The D-enantiomer is an important intermediate in glycolysis, gluconeogenesis, and fructose metabolism." [ISBN:0198506732]
subset: gosubset_prok
synonym: "fructose 6-phosphate metabolism" EXACT []
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:0006003
name: fructose 2,6-bisphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fructose 2,6-bisphosphate. The D enantiomer is an important regulator of the glycolytic and gluconeogenic pathways. It inhibits fructose 1,6-bisphosphatase and activates phosphofructokinase." [ISBN:0198506732]
subset: gosubset_prok
synonym: "fructose 2,6-bisphosphate metabolism" EXACT []
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:0006004
name: fucose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fucose, or 6-deoxygalactose, which has two enantiomers, D-fucose and L-fucose." [ISBN:0198506732]
subset: gosubset_prok
synonym: "fucose metabolism" EXACT []
is_a: GO:0019318 ! hexose metabolic process

[Term]
id: GO:0006005
name: L-fucose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-fucose (6-deoxy-L-galactose)." [GOC:jl]
subset: gosubset_prok
synonym: "L-fucose anabolism" EXACT []
synonym: "L-fucose biosynthesis" EXACT []
synonym: "L-fucose formation" EXACT []
synonym: "L-fucose synthesis" EXACT []
is_a: GO:0042353 ! fucose biosynthetic process
is_a: GO:0042354 ! L-fucose metabolic process

[Term]
id: GO:0006006
name: glucose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides." [ISBN:0198506732]
subset: gosubset_prok
synonym: "cellular glucose metabolic process" EXACT [GOC:vw]
synonym: "glucose metabolism" EXACT []
xref: Reactome:REACT_101127 "Glucose metabolism, Arabidopsis thaliana"
xref: Reactome:REACT_101310 "Glucose metabolism, Canis familiaris"
xref: Reactome:REACT_102479 "Glucose metabolism, Staphylococcus aureus N315"
xref: Reactome:REACT_102806 "Glucose metabolism, Xenopus tropicalis"
xref: Reactome:REACT_104683 "Glucose metabolism, Danio rerio"
xref: Reactome:REACT_105053 "Glucose metabolism, Plasmodium falciparum"
xref: Reactome:REACT_106618 "Glucose metabolism, Escherichia coli"
xref: Reactome:REACT_29390 "Glucose metabolism, Caenorhabditis elegans"
xref: Reactome:REACT_30713 "Glucose metabolism, Schizosaccharomyces pombe"
xref: Reactome:REACT_30754 "Glucose metabolism, Drosophila melanogaster"
xref: Reactome:REACT_32548 "Glucose metabolism, Sus scrofa"
xref: Reactome:REACT_723 "Glucose metabolism, Homo sapiens"
xref: Reactome:REACT_80637 "Glucose metabolism, Mus musculus"
xref: Reactome:REACT_81545 "Glucose metabolism, Bos taurus"
xref: Reactome:REACT_85067 "Glucose metabolism, Gallus gallus"
xref: Reactome:REACT_85844 "Glucose metabolism, Dictyostelium discoideum"
xref: Reactome:REACT_94241 "Glucose metabolism, Saccharomyces cerevisiae"
xref: Reactome:REACT_97466 "Glucose metabolism, Rattus norvegicus"
xref: Reactome:REACT_98401 "Glucose metabolism, Taeniopygia guttata"
xref: Reactome:REACT_98764 "Glucose metabolism, Oryza sativa"
xref: Reactome:REACT_99558 "Glucose metabolism, Mycobacterium tuberculosis"
is_a: GO:0019318 ! hexose metabolic process

[Term]
id: GO:0006007
name: glucose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose." [GOC:ai]
subset: gosubset_prok
synonym: "glucose breakdown" EXACT []
synonym: "glucose catabolism" EXACT []
synonym: "glucose degradation" EXACT []
is_a: GO:0006006 ! glucose metabolic process
is_a: GO:0019320 ! hexose catabolic process

[Term]
id: GO:0006009
name: glucose 1-phosphate phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group into glucose 1-phosphate to produce glucose bisphosphate." [GOC:ai]
subset: gosubset_prok
is_a: GO:0016310 ! phosphorylation
is_a: GO:0019255 ! glucose 1-phosphate metabolic process

[Term]
id: GO:0006011
name: UDP-glucose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "UDP-glucose metabolism" EXACT []
is_a: GO:0009225 ! nucleotide-sugar metabolic process

[Term]
id: GO:0006012
name: galactose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." [ISBN:0198506732]
subset: gosubset_prok
synonym: "galactose metabolism" EXACT []
xref: Wikipedia:Galactose
is_a: GO:0019318 ! hexose metabolic process

[Term]
id: GO:0006013
name: mannose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins." [ISBN:0198506732]
subset: gosubset_prok
synonym: "mannose metabolism" EXACT []
is_a: GO:0019318 ! hexose metabolic process

[Term]
id: GO:0006014
name: D-ribose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-ribose (ribo-pentose). As beta-D-ribofuranose, D-ribose forms the glycose group of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12." [ISBN:0198506732]
subset: gosubset_prok
synonym: "D-ribose metabolism" EXACT []
is_a: GO:0019321 ! pentose metabolic process

[Term]
id: GO:0006015
name: 5-phosphoribose 1-diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 5-phosphoribose 1-diphosphate, also known as 5-phosphoribosyl-1-pyrophosphate." [GOC:ai]
subset: gosubset_prok
synonym: "5-phosphoribose 1-diphosphate anabolism" EXACT []
synonym: "5-phosphoribose 1-diphosphate biosynthesis" EXACT []
synonym: "5-phosphoribose 1-diphosphate formation" EXACT []
synonym: "5-phosphoribose 1-diphosphate synthesis" EXACT []
synonym: "5-phosphoribosyl-1-pyrophosphate biosynthesis" EXACT []
synonym: "5-phosphoribosyl-1-pyrophosphate biosynthetic process" EXACT []
synonym: "PRPP biosynthetic process" EXACT []
xref: MetaCyc:PWY0-661
xref: Reactome:REACT_100949 "5-Phosphoribose 1-diphosphate biosynthesis, Arabidopsis thaliana"
xref: Reactome:REACT_101196 "5-Phosphoribose 1-diphosphate biosynthesis, Gallus gallus"
xref: Reactome:REACT_102525 "5-Phosphoribose 1-diphosphate biosynthesis, Caenorhabditis elegans"
xref: Reactome:REACT_105953 "5-Phosphoribose 1-diphosphate biosynthesis, Sus scrofa"
xref: Reactome:REACT_107605 "5-Phosphoribose 1-diphosphate biosynthesis, Mus musculus"
xref: Reactome:REACT_113394 "5-Phosphoribose 1-diphosphate biosynthesis, Xenopus tropicalis"
xref: Reactome:REACT_31544 "5-Phosphoribose 1-diphosphate biosynthesis, Staphylococcus aureus N315"
xref: Reactome:REACT_32065 "5-Phosphoribose 1-diphosphate biosynthesis, Escherichia coli"
xref: Reactome:REACT_33233 "5-Phosphoribose 1-diphosphate biosynthesis, Oryza sativa"
xref: Reactome:REACT_80250 "5-Phosphoribose 1-diphosphate biosynthesis, Schizosaccharomyces pombe"
xref: Reactome:REACT_82332 "5-Phosphoribose 1-diphosphate biosynthesis, Rattus norvegicus"
xref: Reactome:REACT_83850 "5-Phosphoribose 1-diphosphate biosynthesis, Drosophila melanogaster"
xref: Reactome:REACT_84370 "5-Phosphoribose 1-diphosphate biosynthesis, Bos taurus"
xref: Reactome:REACT_84874 "5-Phosphoribose 1-diphosphate biosynthesis, Plasmodium falciparum"
xref: Reactome:REACT_850 "5-Phosphoribose 1-diphosphate biosynthesis, Homo sapiens"
xref: Reactome:REACT_87464 "5-Phosphoribose 1-diphosphate biosynthesis, Dictyostelium discoideum"
xref: Reactome:REACT_89428 "5-Phosphoribose 1-diphosphate biosynthesis, Danio rerio"
xref: Reactome:REACT_94601 "5-Phosphoribose 1-diphosphate biosynthesis, Canis familiaris"
xref: Reactome:REACT_96150 "5-Phosphoribose 1-diphosphate biosynthesis, Mycobacterium tuberculosis"
xref: Reactome:REACT_99058 "5-Phosphoribose 1-diphosphate biosynthesis, Saccharomyces cerevisiae"
is_a: GO:0046390 ! ribose phosphate biosynthetic process
is_a: GO:0046391 ! 5-phosphoribose 1-diphosphate metabolic process

[Term]
id: GO:0006016
name: 2-deoxyribose 1-phosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 2-deoxyribose 1-phosphate, the phosphorylated sugar 1-phospho-2-deoxyribose." [ISBN:0198506732]
subset: gosubset_prok
synonym: "2-deoxyribose 1-phosphate anabolism" EXACT []
synonym: "2-deoxyribose 1-phosphate biosynthesis" EXACT []
synonym: "2-deoxyribose 1-phosphate formation" EXACT []
synonym: "2-deoxyribose 1-phosphate synthesis" EXACT []
is_a: GO:0046384 ! 2-deoxyribose 1-phosphate metabolic process
is_a: GO:0046385 ! deoxyribose phosphate biosynthetic process

[Term]
id: GO:0006017
name: deoxyribose 1,5-bisphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of deoxyribose 1,5-bisphosphate, the diphosphorylated sugar 1,5-diphospho-2-deoxyribose." [GOC:ai]
subset: gosubset_prok
synonym: "deoxyribose 1,5-bisphosphate anabolism" EXACT []
synonym: "deoxyribose 1,5-bisphosphate biosynthesis" EXACT []
synonym: "deoxyribose 1,5-bisphosphate formation" EXACT []
synonym: "deoxyribose 1,5-bisphosphate synthesis" EXACT []
is_a: GO:0046385 ! deoxyribose phosphate biosynthetic process
is_a: GO:0046387 ! deoxyribose 1,5-bisphosphate metabolic process

[Term]
id: GO:0006018
name: 2-deoxyribose 1-phosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of deoxyribose 1-phosphate, the phosphorylated sugar 1-phospho-2-deoxyribose." [GOC:ai]
subset: gosubset_prok
synonym: "2-deoxyribose 1-phosphate breakdown" EXACT []
synonym: "2-deoxyribose 1-phosphate catabolism" EXACT []
synonym: "2-deoxyribose 1-phosphate degradation" EXACT []
synonym: "deoxyribose 1-phosphate catabolic process" EXACT [GOC:mah]
is_a: GO:0046384 ! 2-deoxyribose 1-phosphate metabolic process
is_a: GO:0046386 ! deoxyribose phosphate catabolic process

[Term]
id: GO:0006019
name: deoxyribose 5-phosphate phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group into deoxyribose 5-phosphate to produce deoxyribose bisphosphate." [GOC:ai]
subset: gosubset_prok
is_a: GO:0016310 ! phosphorylation
is_a: GO:0046389 ! deoxyribose 5-phosphate metabolic process

[Term]
id: GO:0006020
name: inositol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms." [CHEBI:24848, ISBN:0198547684]
subset: gosubset_prok
synonym: "inositol metabolism" EXACT []
synonym: "myo-inositol metabolic process" NARROW []
synonym: "myo-inositol metabolism" NARROW []
synonym: "vitamin Bh metabolic process" EXACT []
synonym: "vitamin Bh metabolism" EXACT []
xref: Wikipedia:Inositol
is_a: GO:0019751 ! polyol metabolic process
is_a: GO:0044262 ! cellular carbohydrate metabolic process
is_a: GO:0044723 ! single-organism carbohydrate metabolic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0006021
name: inositol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms." [CHEBI:24848, ISBN:0198547684]
subset: gosubset_prok
synonym: "inositol anabolism" EXACT []
synonym: "inositol biosynthesis" EXACT []
synonym: "inositol formation" EXACT []
synonym: "inositol synthesis" EXACT []
synonym: "myo-inositol biosynthesis" NARROW []
synonym: "myo-inositol biosynthetic process" NARROW []
synonym: "vitamin Bh biosynthesis" EXACT []
synonym: "vitamin Bh biosynthetic process" EXACT []
is_a: GO:0006020 ! inositol metabolic process
is_a: GO:0034637 ! cellular carbohydrate biosynthetic process
is_a: GO:0046173 ! polyol biosynthetic process

[Term]
id: GO:0006022
name: aminoglycan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages." [GOC:ai, ISBN:0198506732]
subset: gosubset_prok
synonym: "aminoglycan metabolism" EXACT []
is_a: GO:0043170 ! macromolecule metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process

[Term]
id: GO:0006023
name: aminoglycan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages." [GOC:ai, ISBN:0198506732]
subset: gosubset_prok
synonym: "aminoglycan anabolism" EXACT []
synonym: "aminoglycan biosynthesis" EXACT []
synonym: "aminoglycan formation" EXACT []
synonym: "aminoglycan synthesis" EXACT []
is_a: GO:0006022 ! aminoglycan metabolic process
is_a: GO:0009059 ! macromolecule biosynthetic process
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process

[Term]
id: GO:0006024
name: glycosaminoglycan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars." [ISBN:0192800981]
subset: gosubset_prok
synonym: "glycosaminoglycan anabolism" EXACT []
synonym: "glycosaminoglycan biosynthesis" EXACT []
synonym: "glycosaminoglycan formation" EXACT []
synonym: "glycosaminoglycan synthesis" EXACT []
is_a: GO:0006023 ! aminoglycan biosynthetic process
is_a: GO:0030203 ! glycosaminoglycan metabolic process

[Term]
id: GO:0006025
name: galactosaminoglycan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of galactosaminoglycans, any of a group of polysaccharides that contain amino sugars derived from the galactose." [GOC:ai]
subset: gosubset_prok
synonym: "galactosaminoglycan anabolism" EXACT []
synonym: "galactosaminoglycan biosynthesis" EXACT []
synonym: "galactosaminoglycan formation" EXACT []
synonym: "galactosaminoglycan synthesis" EXACT []
is_a: GO:0006024 ! glycosaminoglycan biosynthetic process
is_a: GO:0046350 ! galactosaminoglycan metabolic process

[Term]
id: GO:0006026
name: aminoglycan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages." [GOC:ai, ISBN:0198506732]
subset: gosubset_prok
synonym: "aminoglycan breakdown" EXACT []
synonym: "aminoglycan catabolism" EXACT []
synonym: "aminoglycan degradation" EXACT []
is_a: GO:0006022 ! aminoglycan metabolic process
is_a: GO:0009057 ! macromolecule catabolic process
is_a: GO:1901136 ! carbohydrate derivative catabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process

[Term]
id: GO:0006027
name: glycosaminoglycan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars." [ISBN:0192800981]
subset: gosubset_prok
synonym: "glycosaminoglycan breakdown" EXACT []
synonym: "glycosaminoglycan catabolism" EXACT []
synonym: "glycosaminoglycan degradation" EXACT []
is_a: GO:0006026 ! aminoglycan catabolic process
is_a: GO:0030203 ! glycosaminoglycan metabolic process

[Term]
id: GO:0006028
name: galactosaminoglycan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of galactosaminoglycans, any of a group of polysaccharides that contain amino sugars derived from the galactose." [GOC:ai]
subset: gosubset_prok
synonym: "galactosaminoglycan breakdown" EXACT []
synonym: "galactosaminoglycan catabolism" EXACT []
synonym: "galactosaminoglycan degradation" EXACT []
is_a: GO:0006027 ! glycosaminoglycan catabolic process
is_a: GO:0044712 ! single-organism catabolic process
is_a: GO:0046350 ! galactosaminoglycan metabolic process

[Term]
id: GO:0006029
name: proteoglycan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [GOC:mah, ISBN:0198506732]
subset: gosubset_prok
synonym: "proteoglycan metabolism" EXACT []
synonym: "proteoglycan sulfate transfer" NARROW []
is_a: GO:0009100 ! glycoprotein metabolic process

[Term]
id: GO:0006030
name: chitin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "beta-1,4-linked N-acetylglucosamine metabolic process" EXACT []
synonym: "beta-1,4-linked N-acetylglucosamine metabolism" EXACT []
synonym: "chitin metabolism" EXACT []
is_a: GO:0006022 ! aminoglycan metabolic process
is_a: GO:1901071 ! glucosamine-containing compound metabolic process

[Term]
id: GO:0006031
name: chitin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "beta-1,4-linked N-acetylglucosamine biosynthesis" EXACT []
synonym: "beta-1,4-linked N-acetylglucosamine biosynthetic process" EXACT []
synonym: "chitin anabolism" EXACT []
synonym: "chitin biosynthesis" EXACT []
synonym: "chitin formation" EXACT []
synonym: "chitin synthesis" EXACT []
is_a: GO:0006023 ! aminoglycan biosynthetic process
is_a: GO:0006030 ! chitin metabolic process
is_a: GO:1901073 ! glucosamine-containing compound biosynthetic process

[Term]
id: GO:0006032
name: chitin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "beta-1,4-linked N-acetylglucosamine catabolic process" EXACT []
synonym: "beta-1,4-linked N-acetylglucosamine catabolism" EXACT []
synonym: "chitin breakdown" EXACT []
synonym: "chitin catabolism" EXACT []
synonym: "chitin degradation" EXACT []
is_a: GO:0006026 ! aminoglycan catabolic process
is_a: GO:0006030 ! chitin metabolic process
is_a: GO:1901072 ! glucosamine-containing compound catabolic process

[Term]
id: GO:0006033
name: chitin localization
namespace: biological_process
def: "A process in which chitin is transported to, or maintained in, a specific location." [GOC:ai]
subset: gosubset_prok
synonym: "chitin localisation" EXACT [GOC:mah]
synonym: "establishment and maintenance of chitin localization" EXACT []
is_a: GO:0033037 ! polysaccharide localization

[Term]
id: GO:0006034
name: cuticle chitin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cuticle chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in cuticles." [GOC:ai]
synonym: "cuticle chitin metabolism" EXACT []
is_a: GO:0006030 ! chitin metabolic process

[Term]
id: GO:0006035
name: cuticle chitin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cuticle chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in cuticles." [GOC:ai]
synonym: "cuticle chitin anabolism" EXACT []
synonym: "cuticle chitin biosynthesis" EXACT []
synonym: "cuticle chitin formation" EXACT []
synonym: "cuticle chitin synthesis" EXACT []
is_a: GO:0006031 ! chitin biosynthetic process
is_a: GO:0006034 ! cuticle chitin metabolic process
relationship: part_of GO:0040003 ! chitin-based cuticle development

[Term]
id: GO:0006036
name: cuticle chitin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cuticle chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in cuticles." [GOC:ai]
synonym: "cuticle chitin breakdown" EXACT []
synonym: "cuticle chitin catabolism" EXACT []
synonym: "cuticle chitin degradation" EXACT []
is_a: GO:0006032 ! chitin catabolic process
is_a: GO:0006034 ! cuticle chitin metabolic process

[Term]
id: GO:0006037
name: cell wall chitin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cell wall chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in the walls of cells." [GOC:ai]
subset: gosubset_prok
synonym: "cell wall chitin metabolism" EXACT []
is_a: GO:0006030 ! chitin metabolic process
is_a: GO:0010383 ! cell wall polysaccharide metabolic process

[Term]
id: GO:0006038
name: cell wall chitin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cell wall chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in the walls of cells." [GOC:ai]
synonym: "cell wall chitin anabolism" EXACT []
synonym: "cell wall chitin biosynthesis" EXACT []
synonym: "cell wall chitin formation" EXACT []
synonym: "cell wall chitin synthesis" EXACT []
is_a: GO:0006031 ! chitin biosynthetic process
is_a: GO:0006037 ! cell wall chitin metabolic process
is_a: GO:0070592 ! cell wall polysaccharide biosynthetic process

[Term]
id: GO:0006039
name: cell wall chitin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cell wall chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in the walls of cells." [GOC:ai]
subset: gosubset_prok
synonym: "cell wall chitin breakdown" EXACT []
synonym: "cell wall chitin catabolism" EXACT []
synonym: "cell wall chitin degradation" EXACT []
is_a: GO:0006032 ! chitin catabolic process
is_a: GO:0006037 ! cell wall chitin metabolic process
is_a: GO:0016998 ! cell wall macromolecule catabolic process

[Term]
id: GO:0006040
name: amino sugar metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any amino sugar, sugars containing an amino group in place of a hydroxyl group." [GOC:jl, ISBN:0192801023]
subset: gosubset_prok
synonym: "amino sugar metabolism" EXACT []
synonym: "aminosaccharide metabolic process" EXACT []
synonym: "aminosaccharide metabolism" EXACT []
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:0006041
name: glucosamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glucosamine (2-amino-2-deoxyglucopyranose), an aminodeoxysugar that occurs in combined form in chitin." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "chitosamine metabolic process" EXACT []
synonym: "chitosamine metabolism" EXACT []
synonym: "glucosamine metabolism" EXACT []
is_a: GO:1901071 ! glucosamine-containing compound metabolic process

[Term]
id: GO:0006042
name: glucosamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glucosamine (2-amino-2-deoxyglucopyranose), an aminodeoxysugar that occurs in combined form in chitin." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "chitosamine biosynthesis" EXACT []
synonym: "chitosamine biosynthetic process" EXACT []
synonym: "glucosamine anabolism" EXACT []
synonym: "glucosamine biosynthesis" EXACT []
synonym: "glucosamine formation" EXACT []
synonym: "glucosamine synthesis" EXACT []
is_a: GO:0006041 ! glucosamine metabolic process
is_a: GO:1901073 ! glucosamine-containing compound biosynthetic process

[Term]
id: GO:0006043
name: glucosamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glucosamine (2-amino-2-deoxyglucopyranose), an aminodeoxysugar that occurs in combined form in chitin." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "chitosamine catabolic process" EXACT []
synonym: "chitosamine catabolism" EXACT []
synonym: "glucosamine breakdown" EXACT []
synonym: "glucosamine catabolism" EXACT []
synonym: "glucosamine degradation" EXACT []
xref: MetaCyc:GLUAMCAT-PWY
is_a: GO:0006041 ! glucosamine metabolic process
is_a: GO:1901072 ! glucosamine-containing compound catabolic process

[Term]
id: GO:0006044
name: N-acetylglucosamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein." [ISBN:0198506732]
subset: gosubset_prok
synonym: "N-acetylglucosamine metabolism" EXACT []
is_a: GO:1901071 ! glucosamine-containing compound metabolic process

[Term]
id: GO:0006045
name: N-acetylglucosamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein." [ISBN:0198506732]
subset: gosubset_prok
synonym: "N-acetylglucosamine anabolism" EXACT []
synonym: "N-acetylglucosamine biosynthesis" EXACT []
synonym: "N-acetylglucosamine formation" EXACT []
synonym: "N-acetylglucosamine synthesis" EXACT []
is_a: GO:0006044 ! N-acetylglucosamine metabolic process
is_a: GO:1901073 ! glucosamine-containing compound biosynthetic process

[Term]
id: GO:0006046
name: N-acetylglucosamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein." [ISBN:0198506732]
subset: gosubset_prok
synonym: "N-acetylglucosamine breakdown" EXACT []
synonym: "N-acetylglucosamine catabolism" EXACT []
synonym: "N-acetylglucosamine degradation" EXACT []
is_a: GO:0006044 ! N-acetylglucosamine metabolic process
is_a: GO:1901072 ! glucosamine-containing compound catabolic process

[Term]
id: GO:0006047
name: UDP-N-acetylglucosamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "UDP-N-acetylglucosamine metabolism" EXACT []
is_a: GO:0006040 ! amino sugar metabolic process
is_a: GO:0009225 ! nucleotide-sugar metabolic process

[Term]
id: GO:0006048
name: UDP-N-acetylglucosamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "UDP-GlcNAc biosynthesis" EXACT []
synonym: "UDP-GlcNAc biosynthetic process" EXACT []
synonym: "UDP-N-acetylglucosamine anabolism" EXACT []
synonym: "UDP-N-acetylglucosamine biosynthesis" EXACT []
synonym: "UDP-N-acetylglucosamine formation" EXACT []
synonym: "UDP-N-acetylglucosamine synthesis" EXACT []
xref: MetaCyc:UDPNAGSYN-PWY
xref: Reactome:REACT_22394 "Synthesis of UDP-N-acetyl-glucosamine, Homo sapiens"
is_a: GO:0006047 ! UDP-N-acetylglucosamine metabolic process
is_a: GO:0009226 ! nucleotide-sugar biosynthetic process
is_a: GO:0046349 ! amino sugar biosynthetic process

[Term]
id: GO:0006049
name: UDP-N-acetylglucosamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "UDP-N-acetylglucosamine breakdown" EXACT []
synonym: "UDP-N-acetylglucosamine catabolism" EXACT []
synonym: "UDP-N-acetylglucosamine degradation" EXACT []
is_a: GO:0006047 ! UDP-N-acetylglucosamine metabolic process
is_a: GO:0009227 ! nucleotide-sugar catabolic process
is_a: GO:0046348 ! amino sugar catabolic process

[Term]
id: GO:0006050
name: mannosamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mannosomine, 2-amino-2-deoxymannose; the D-isomer is a constituent of neuraminic acids as well as mucolipids and mucoproteins." [CHEBI:mannosamine, GOC:curators]
subset: gosubset_prok
synonym: "mannosamine metabolism" EXACT []
is_a: GO:0006040 ! amino sugar metabolic process

[Term]
id: GO:0006051
name: N-acetylmannosamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving N-acetylmannosamine, the acetylated derivative of mannosamine, 2-amino-2-deoxymannose." [GOC:ai, ISBN:0198506732]
subset: gosubset_prok
synonym: "N-acetylmannosamine metabolism" EXACT []
is_a: GO:0006050 ! mannosamine metabolic process

[Term]
id: GO:0006052
name: N-acetylmannosamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of N-acetylmannosamine, the acetylated derivative of mannosamine, 2-amino-2-deoxymannose." [GOC:ai, ISBN:0198506732]
subset: gosubset_prok
synonym: "N-acetylmannosamine anabolism" EXACT []
synonym: "N-acetylmannosamine biosynthesis" EXACT []
synonym: "N-acetylmannosamine formation" EXACT []
synonym: "N-acetylmannosamine synthesis" EXACT []
is_a: GO:0006051 ! N-acetylmannosamine metabolic process
is_a: GO:0046347 ! mannosamine biosynthetic process

[Term]
id: GO:0006053
name: N-acetylmannosamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of N-acetylmannosamine, the acetylated derivative of mannosamine, 2-amino-2-deoxymannose." [GOC:ai, ISBN:0198506732]
subset: gosubset_prok
synonym: "N-acetylmannosamine breakdown" EXACT []
synonym: "N-acetylmannosamine catabolism" EXACT []
synonym: "N-acetylmannosamine degradation" EXACT []
is_a: GO:0006051 ! N-acetylmannosamine metabolic process
is_a: GO:0046346 ! mannosamine catabolic process

[Term]
id: GO:0006054
name: N-acetylneuraminate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving N-acetylneuraminate, the anion of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid." [ISBN:0198506732]
subset: gosubset_prok
synonym: "N-acetylneuraminate metabolism" EXACT []
synonym: "sialic acid metabolic process" BROAD []
synonym: "sialic acid metabolism" BROAD []
is_a: GO:0006040 ! amino sugar metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0006055
name: CMP-N-acetylneuraminate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of CMP-N-acetylneuraminate, a substance composed of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid in glycosidic linkage with cytidine monophosphate." [GOC:ai]
subset: gosubset_prok
synonym: "CMP-N-acetylneuraminate anabolism" EXACT []
synonym: "CMP-N-acetylneuraminate biosynthesis" EXACT []
synonym: "CMP-N-acetylneuraminate formation" EXACT []
synonym: "CMP-N-acetylneuraminate synthesis" EXACT []
is_a: GO:0009226 ! nucleotide-sugar biosynthetic process
is_a: GO:0046381 ! CMP-N-acetylneuraminate metabolic process

[Term]
id: GO:0006056
name: mannoprotein metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mannoproteins, any protein that contains covalently bound mannose residues." [ISBN:0198506732]
subset: gosubset_prok
synonym: "mannoprotein metabolism" EXACT []
is_a: GO:0009100 ! glycoprotein metabolic process

[Term]
id: GO:0006057
name: mannoprotein biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of mannoproteins, any protein that contains covalently bound mannose residues." [ISBN:0198506732]
subset: gosubset_prok
synonym: "mannoprotein anabolism" EXACT []
synonym: "mannoprotein biosynthesis" EXACT []
synonym: "mannoprotein formation" EXACT []
synonym: "mannoprotein synthesis" EXACT []
is_a: GO:0006056 ! mannoprotein metabolic process
is_a: GO:0009101 ! glycoprotein biosynthetic process

[Term]
id: GO:0006058
name: mannoprotein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of mannoproteins, any protein that contains covalently bound mannose residues." [ISBN:0198506732]
subset: gosubset_prok
synonym: "mannoprotein breakdown" EXACT []
synonym: "mannoprotein catabolism" EXACT []
synonym: "mannoprotein degradation" EXACT []
is_a: GO:0006056 ! mannoprotein metabolic process
is_a: GO:0006516 ! glycoprotein catabolic process
is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process

[Term]
id: GO:0006059
name: hexitol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving hexitols, any alditol with a chain of six carbon atoms in the molecule." [ISBN:0198506732]
subset: gosubset_prok
synonym: "hexitol metabolism" EXACT []
synonym: "sugar alcohol (hexitol) metabolic process" EXACT []
synonym: "sugar alcohol (hexitol) metabolism" EXACT []
is_a: GO:0019400 ! alditol metabolic process

[Term]
id: GO:0006060
name: sorbitol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sorbitol (D-glucitol), one of the ten stereoisomeric hexitols. It can be derived from glucose by reduction of the aldehyde group." [ISBN:0198506732]
subset: gosubset_prok
synonym: "sorbitol metabolism" EXACT []
xref: MetaCyc:P461-PWY
is_a: GO:0006059 ! hexitol metabolic process

[Term]
id: GO:0006061
name: sorbitol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sorbitol (D-glucitol), one of the ten stereoisomeric hexitols. It can be derived from glucose by reduction of the aldehyde group." [ISBN:0198506732]
subset: gosubset_prok
synonym: "sorbitol anabolism" EXACT []
synonym: "sorbitol biosynthesis" EXACT []
synonym: "sorbitol formation" EXACT []
synonym: "sorbitol synthesis" EXACT []
is_a: GO:0006060 ! sorbitol metabolic process
is_a: GO:0019406 ! hexitol biosynthetic process

[Term]
id: GO:0006062
name: sorbitol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of sorbitol (D-glucitol), one of the ten stereoisomeric hexitols. It can be derived from glucose by reduction of the aldehyde group." [ISBN:0198506732]
subset: gosubset_prok
synonym: "sorbitol breakdown" EXACT []
synonym: "sorbitol catabolism" EXACT []
synonym: "sorbitol degradation" EXACT []
xref: MetaCyc:SORBDEG-PWY
is_a: GO:0006060 ! sorbitol metabolic process
is_a: GO:0019407 ! hexitol catabolic process

[Term]
id: GO:0006063
name: uronic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving uronic acid, any monocarboxylic acid formally derived by oxidizing to a carboxyl group the terminal hydroxymethylene group of either an aldose with four or more carbon atoms in the molecule, or of any glycoside derived from such an aldose." [ISBN:0198506732]
subset: gosubset_prok
synonym: "uronic acid metabolism" EXACT []
is_a: GO:0005996 ! monosaccharide metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0006064
name: glucuronate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glucuronate, any salt or ester of glucuronic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "glucuronate breakdown" EXACT []
synonym: "glucuronate catabolism" EXACT []
synonym: "glucuronate degradation" EXACT []
is_a: GO:0019585 ! glucuronate metabolic process
is_a: GO:0046365 ! monosaccharide catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0006065
name: UDP-glucuronate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of UDP-glucuronate, a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "UDP-glucuronate anabolism" EXACT []
synonym: "UDP-glucuronate biosynthesis" EXACT []
synonym: "UDP-glucuronate formation" EXACT []
synonym: "UDP-glucuronate synthesis" EXACT []
xref: MetaCyc:PWY-4841
xref: Reactome:REACT_104017 "Formation of the active cofactor, UDP-glucuronate, Staphylococcus aureus N315"
xref: Reactome:REACT_104104 "Formation of the active cofactor, UDP-glucuronate, Dictyostelium discoideum"
xref: Reactome:REACT_107830 "Formation of the active cofactor, UDP-glucuronate, Sus scrofa"
xref: Reactome:REACT_108572 "Formation of the active cofactor, UDP-glucuronate, Taeniopygia guttata"
xref: Reactome:REACT_113773 "Formation of the active cofactor, UDP-glucuronate, Escherichia coli"
xref: Reactome:REACT_28339 "Formation of the active cofactor, UDP-glucuronate, Mus musculus"
xref: Reactome:REACT_28461 "Formation of the active cofactor, UDP-glucuronate, Canis familiaris"
xref: Reactome:REACT_33265 "Formation of the active cofactor, UDP-glucuronate, Mycobacterium tuberculosis"
xref: Reactome:REACT_34051 "Formation of the active cofactor, UDP-glucuronate, Saccharomyces cerevisiae"
xref: Reactome:REACT_43579 "Formation of the active cofactor, UDP-glucuronate, Gallus gallus"
xref: Reactome:REACT_6737 "Formation of the active cofactor, UDP-glucuronate, Homo sapiens"
xref: Reactome:REACT_77824 "Formation of the active cofactor, UDP-glucuronate, Xenopus tropicalis"
xref: Reactome:REACT_77971 "Formation of the active cofactor, UDP-glucuronate, Schizosaccharomyces pombe"
xref: Reactome:REACT_82919 "Formation of the active cofactor, UDP-glucuronate, Caenorhabditis elegans"
xref: Reactome:REACT_84890 "Formation of the active cofactor, UDP-glucuronate, Arabidopsis thaliana"
xref: Reactome:REACT_88063 "Formation of the active cofactor, UDP-glucuronate, Drosophila melanogaster"
xref: Reactome:REACT_88239 "Formation of the active cofactor, UDP-glucuronate, Bos taurus"
xref: Reactome:REACT_92141 "Formation of the active cofactor, UDP-glucuronate, Rattus norvegicus"
xref: Reactome:REACT_94827 "Formation of the active cofactor, UDP-glucuronate, Danio rerio"
xref: Reactome:REACT_95140 "Formation of the active cofactor, UDP-glucuronate, Oryza sativa"
is_a: GO:0009226 ! nucleotide-sugar biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
is_a: GO:0046398 ! UDP-glucuronate metabolic process

[Term]
id: GO:0006066
name: alcohol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
synonym: "alcohol metabolism" EXACT []
is_a: GO:0044281 ! small molecule metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process

[Term]
id: GO:0006067
name: ethanol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation." [GOC:ai, ISBN:0198506732]
subset: gosubset_prok
synonym: "ethanol metabolism" EXACT []
is_a: GO:0034308 ! primary alcohol metabolic process

[Term]
id: GO:0006068
name: ethanol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation." [GOC:ai, ISBN:0198506732]
subset: gosubset_prok
synonym: "ethanol breakdown" EXACT []
synonym: "ethanol catabolism" EXACT []
synonym: "ethanol degradation" EXACT []
is_a: GO:0006067 ! ethanol metabolic process
is_a: GO:0034310 ! primary alcohol catabolic process

[Term]
id: GO:0006069
name: ethanol oxidation
namespace: biological_process
def: "An ethanol metabolic process in which ethanol is converted to acetyl-CoA via acetaldehyde and acetate." [GOC:mah, MetaCyc:PWY66-161, MetaCyc:PWY66-162, MetaCyc:PWY66-21]
subset: gosubset_prok
xref: Reactome:REACT_102011 "Ethanol oxidation, Danio rerio"
xref: Reactome:REACT_107215 "Ethanol oxidation, Mycobacterium tuberculosis"
xref: Reactome:REACT_107915 "Ethanol oxidation, Taeniopygia guttata"
xref: Reactome:REACT_108447 "Ethanol oxidation, Arabidopsis thaliana"
xref: Reactome:REACT_108632 "Ethanol oxidation, Gallus gallus"
xref: Reactome:REACT_110742 "Ethanol oxidation, Rattus norvegicus"
xref: Reactome:REACT_113258 "Ethanol oxidation, Dictyostelium discoideum"
xref: Reactome:REACT_114164 "Ethanol oxidation, Escherichia coli"
xref: Reactome:REACT_34 "Ethanol oxidation, Homo sapiens"
xref: Reactome:REACT_77169 "Ethanol oxidation, Bos taurus"
xref: Reactome:REACT_79123 "Ethanol oxidation, Oryza sativa"
xref: Reactome:REACT_84093 "Ethanol oxidation, Mus musculus"
xref: Reactome:REACT_86318 "Ethanol oxidation, Sus scrofa"
xref: Reactome:REACT_88209 "Ethanol oxidation, Caenorhabditis elegans"
xref: Reactome:REACT_90017 "Ethanol oxidation, Canis familiaris"
xref: Reactome:REACT_92353 "Ethanol oxidation, Xenopus tropicalis"
xref: Reactome:REACT_95892 "Ethanol oxidation, Drosophila melanogaster"
is_a: GO:0006067 ! ethanol metabolic process
is_a: GO:0055114 ! oxidation-reduction process

[Term]
id: GO:0006070
name: octanol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving octanol, the 8-carbon alcohol with the formula C8H17OH." [GOC:go_curators]
subset: gosubset_prok
synonym: "octanol metabolism" EXACT []
is_a: GO:0034308 ! primary alcohol metabolic process
is_a: GO:1903173 ! fatty alcohol metabolic process

[Term]
id: GO:0006071
name: glycerol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai, ISBN:0198506732]
subset: gosubset_prok
synonym: "glycerol metabolism" EXACT []
xref: MetaCyc:GLYCEROLMETAB-PWY
is_a: GO:0019400 ! alditol metabolic process

[Term]
id: GO:0006072
name: glycerol-3-phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "glycerol-3-phosphate metabolism" EXACT []
is_a: GO:0052646 ! alditol phosphate metabolic process

[Term]
id: GO:0006073
name: cellular glucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues." [ISBN:0198547684]
subset: gosubset_prok
synonym: "cellular glucan metabolism" EXACT []
is_a: GO:0044042 ! glucan metabolic process
is_a: GO:0044264 ! cellular polysaccharide metabolic process

[Term]
id: GO:0006074
name: (1->3)-beta-D-glucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds." [ISBN:0198506732]
subset: gosubset_prok
synonym: "1,3-beta-D-glucan metabolic process" BROAD [GOC:tb]
synonym: "1,3-beta-D-glucan metabolism" EXACT []
synonym: "1,3-beta-glucan metabolic process" BROAD [GOC:tb]
synonym: "beta-1,3 glucan metabolic process" EXACT []
synonym: "beta-1,3 glucan metabolism" EXACT []
is_a: GO:0051273 ! beta-glucan metabolic process

[Term]
id: GO:0006075
name: (1->3)-beta-D-glucan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds." [GOC:ai]
synonym: "1,3-beta-D-glucan biosynthetic process" EXACT []
synonym: "1,3-beta-glucan anabolism" EXACT []
synonym: "1,3-beta-glucan biosynthesis" EXACT []
synonym: "1,3-beta-glucan formation" EXACT []
synonym: "1,3-beta-glucan synthesis" EXACT []
synonym: "beta-1,3 glucan anabolism" EXACT []
synonym: "beta-1,3 glucan biosynthesis" EXACT []
synonym: "beta-1,3 glucan biosynthetic process" EXACT []
synonym: "beta-1,3 glucan formation" EXACT []
synonym: "beta-1,3 glucan synthesis" EXACT []
is_a: GO:0006074 ! (1->3)-beta-D-glucan metabolic process
is_a: GO:0051274 ! beta-glucan biosynthetic process

[Term]
id: GO:0006076
name: (1->3)-beta-D-glucan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of (1->3)-beta-D-glucans." [GOC:ai]
subset: gosubset_prok
synonym: "1,3-beta-D-glucan catabolic process" EXACT []
synonym: "1,3-beta-glucan breakdown" EXACT []
synonym: "1,3-beta-glucan catabolism" EXACT []
synonym: "1,3-beta-glucan degradation" EXACT []
synonym: "beta-1,3 glucan breakdown" EXACT []
synonym: "beta-1,3 glucan catabolic process" EXACT []
synonym: "beta-1,3 glucan catabolism" EXACT []
synonym: "beta-1,3 glucan degradation" EXACT []
is_a: GO:0006074 ! (1->3)-beta-D-glucan metabolic process
is_a: GO:0051275 ! beta-glucan catabolic process

[Term]
id: GO:0006077
name: (1->6)-beta-D-glucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (1->6)-beta-D-glucans, compounds composed of glucose residues linked by (1->6)-beta-D-glucosidic bonds." [ISBN:0198506732]
subset: gosubset_prok
synonym: "1,6-beta-glucan metabolic process" EXACT []
synonym: "1,6-beta-glucan metabolism" EXACT []
synonym: "beta-1,6 glucan metabolic process" EXACT []
synonym: "beta-1,6 glucan metabolism" EXACT []
is_a: GO:0051273 ! beta-glucan metabolic process

[Term]
id: GO:0006078
name: (1->6)-beta-D-glucan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (1->6)-beta-D-glucans." [GOC:ai]
synonym: "1,6-beta-glucan anabolism" EXACT []
synonym: "1,6-beta-glucan biosynthesis" EXACT []
synonym: "1,6-beta-glucan biosynthetic process" EXACT []
synonym: "1,6-beta-glucan formation" EXACT []
synonym: "1,6-beta-glucan synthesis" EXACT []
synonym: "beta-1,6 glucan anabolism" EXACT []
synonym: "beta-1,6 glucan biosynthesis" EXACT []
synonym: "beta-1,6 glucan biosynthetic process" EXACT []
synonym: "beta-1,6 glucan formation" EXACT []
synonym: "beta-1,6 glucan synthesis" EXACT []
is_a: GO:0006077 ! (1->6)-beta-D-glucan metabolic process
is_a: GO:0051274 ! beta-glucan biosynthetic process

[Term]
id: GO:0006079
name: (1->6)-beta-D-glucan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of (1->6)-beta-D-glucans." [GOC:ai]
subset: gosubset_prok
synonym: "1,6-beta-D-glucan breakdown" EXACT []
synonym: "1,6-beta-D-glucan catabolic process" EXACT []
synonym: "1,6-beta-D-glucan catabolism" EXACT []
synonym: "1,6-beta-D-glucan degradation" EXACT []
synonym: "beta-1,6 glucan breakdown" EXACT []
synonym: "beta-1,6 glucan catabolic process" EXACT []
synonym: "beta-1,6 glucan catabolism" EXACT []
synonym: "beta-1,6 glucan degradation" EXACT []
is_a: GO:0006077 ! (1->6)-beta-D-glucan metabolic process
is_a: GO:0051275 ! beta-glucan catabolic process

[Term]
id: GO:0006080
name: substituted mannan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a mannan backbone composed of D-mannose unites, substituted with D-glucose and/or D-galactose units." [GOC:tair_curators]
subset: gosubset_prok
synonym: "substituted mannan metabolism" EXACT []
is_a: GO:0005976 ! polysaccharide metabolic process

[Term]
id: GO:0006081
name: cellular aldehyde metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells." [GOC:go_curators, ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
synonym: "aldehyde metabolism" EXACT []
synonym: "alkanal metabolic process" EXACT []
synonym: "alkanal metabolism" EXACT []
is_a: GO:0044237 ! cellular metabolic process
is_a: GO:0044710 ! single-organism metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0071704 ! organic substance metabolic process

[Term]
id: GO:0006082
name: organic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
synonym: "organic acid metabolism" EXACT []
is_a: GO:0044237 ! cellular metabolic process
is_a: GO:0044281 ! small molecule metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0071704 ! organic substance metabolic process

[Term]
id: GO:0006083
name: acetate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving acetate, the anion of acetic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "acetate metabolism" EXACT []
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0006084
name: acetyl-CoA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis." [ISBN:0198547684]
subset: gosubset_prok
synonym: "acetyl coenzyme A metabolic process" EXACT []
synonym: "acetyl coenzyme A metabolism" EXACT []
synonym: "acetyl-CoA metabolism" EXACT []
is_a: GO:0006637 ! acyl-CoA metabolic process

[Term]
id: GO:0006085
name: acetyl-CoA biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated." [GOC:go_curators]
subset: gosubset_prok
synonym: "acetyl-CoA anabolism" EXACT []
synonym: "acetyl-CoA biosynthesis" EXACT []
synonym: "acetyl-CoA formation" EXACT []
synonym: "acetyl-CoA synthesis" EXACT []
xref: MetaCyc:PWY-5173
is_a: GO:0006084 ! acetyl-CoA metabolic process
is_a: GO:0071616 ! acyl-CoA biosynthetic process

[Term]
id: GO:0006086
name: acetyl-CoA biosynthetic process from pyruvate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate." [GOC:dph, GOC:go_curators, GOC:tb]
subset: gosubset_prok
synonym: "acetyl-CoA anabolism from pyruvate" EXACT []
synonym: "acetyl-CoA formation from pyruvate" EXACT []
synonym: "acetyl-CoA synthesis from pyruvate" EXACT []
synonym: "pyruvate dehydrogenase pathway" EXACT []
xref: MetaCyc:PYRUVDEHYD-PWY
is_a: GO:0006085 ! acetyl-CoA biosynthetic process
is_a: GO:0006090 ! pyruvate metabolic process
is_a: GO:0044711 ! single-organism biosynthetic process

[Term]
id: GO:0006088
name: obsolete acetate to acetyl-CoA
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a function rather than a process.
synonym: "acetate to acetyl-CoA" EXACT []
is_obsolete: true
consider: GO:0003987

[Term]
id: GO:0006089
name: lactate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lactate, the anion of lactic acid." [ISBN:0198547684]
subset: gosubset_prok
synonym: "2-hydroxypropanoate metabolic process" EXACT []
synonym: "2-hydroxypropanoate metabolism" EXACT []
synonym: "alpha-hydroxypropionate metabolic process" EXACT []
synonym: "alpha-hydroxypropionate metabolism" EXACT []
synonym: "lactate metabolism" EXACT []
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process

[Term]
id: GO:0006090
name: pyruvate metabolic process
namespace: biological_process
alt_id: GO:0006087
def: "The chemical reactions and pathways involving pyruvate, 2-oxopropanoate." [GOC:go_curators]
subset: gosubset_prok
synonym: "pyruvate dehydrogenase bypass" RELATED []
synonym: "pyruvate metabolism" EXACT []
xref: MetaCyc:P41-PWY
xref: Reactome:REACT_100674 "Pyruvate metabolism, Caenorhabditis elegans"
xref: Reactome:REACT_101182 "Pyruvate metabolism, Sus scrofa"
xref: Reactome:REACT_104471 "Pyruvate metabolism, Arabidopsis thaliana"
xref: Reactome:REACT_105136 "Pyruvate metabolism, Staphylococcus aureus N315"
xref: Reactome:REACT_106552 "Pyruvate metabolism, Dictyostelium discoideum"
xref: Reactome:REACT_112876 "Pyruvate metabolism, Drosophila melanogaster"
xref: Reactome:REACT_116019 "Pyruvate metabolism, Gallus gallus"
xref: Reactome:REACT_2071 "Pyruvate metabolism, Homo sapiens"
xref: Reactome:REACT_31681 "Pyruvate metabolism, Mus musculus"
xref: Reactome:REACT_32433 "Pyruvate metabolism, Rattus norvegicus"
xref: Reactome:REACT_34674 "Pyruvate metabolism, Gallus gallus"
xref: Reactome:REACT_78738 "Pyruvate metabolism, Saccharomyces cerevisiae"
xref: Reactome:REACT_85548 "Pyruvate metabolism, Canis familiaris"
xref: Reactome:REACT_93569 "Pyruvate metabolism, Oryza sativa"
xref: Reactome:REACT_95934 "Pyruvate metabolism, Xenopus tropicalis"
xref: Reactome:REACT_96688 "Pyruvate metabolism, Schizosaccharomyces pombe"
xref: Reactome:REACT_97000 "Pyruvate metabolism, Taeniopygia guttata"
xref: Reactome:REACT_98927 "Pyruvate metabolism, Danio rerio"
xref: Reactome:REACT_99092 "Pyruvate metabolism, Bos taurus"
xref: Wikipedia:Pyruvic_acid
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0006091
name: generation of precursor metabolites and energy
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances." [GOC:jl]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "energy pathways" BROAD []
synonym: "intermediary metabolism" RELATED [GOC:mah]
synonym: "metabolic energy generation" RELATED []
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0006094
name: gluconeogenesis
namespace: biological_process
def: "The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [MetaCyc:GLUCONEO-PWY]
subset: gosubset_prok
synonym: "glucose biosynthesis" EXACT []
synonym: "glucose biosynthetic process" EXACT []
xref: MetaCyc:GLUCONEO-PWY
xref: Reactome:REACT_100761 "Gluconeogenesis, Rattus norvegicus"
xref: Reactome:REACT_103550 "Gluconeogenesis, Dictyostelium discoideum"
xref: Reactome:REACT_103754 "Gluconeogenesis, Taeniopygia guttata"
xref: Reactome:REACT_104833 "Gluconeogenesis, Canis familiaris"
xref: Reactome:REACT_106258 "Gluconeogenesis, Danio rerio"
xref: Reactome:REACT_107053 "Gluconeogenesis, Bos taurus"
xref: Reactome:REACT_110653 "Gluconeogenesis, Caenorhabditis elegans"
xref: Reactome:REACT_110776 "Gluconeogenesis, Staphylococcus aureus N315"
xref: Reactome:REACT_115534 "Gluconeogenesis, Gallus gallus"
xref: Reactome:REACT_1520 "Gluconeogenesis, Homo sapiens"
xref: Reactome:REACT_28551 "Gluconeogenesis, Oryza sativa"
xref: Reactome:REACT_30814 "Gluconeogenesis, Mus musculus"
xref: Reactome:REACT_61409 "Gluconeogenesis, Schizosaccharomyces pombe"
xref: Reactome:REACT_77782 "Gluconeogenesis, Drosophila melanogaster"
xref: Reactome:REACT_78124 "Gluconeogenesis, Sus scrofa"
xref: Reactome:REACT_81627 "Gluconeogenesis, Gallus gallus"
xref: Reactome:REACT_90866 "Gluconeogenesis, Saccharomyces cerevisiae"
xref: Reactome:REACT_91053 "Gluconeogenesis, Escherichia coli"
xref: Reactome:REACT_92237 "Gluconeogenesis, Mycobacterium tuberculosis"
xref: Reactome:REACT_93679 "Gluconeogenesis, Xenopus tropicalis"
xref: Reactome:REACT_94976 "Gluconeogenesis, Arabidopsis thaliana"
xref: Reactome:REACT_96138 "Gluconeogenesis, Plasmodium falciparum"
xref: Wikipedia:Gluconeogenesis
is_a: GO:0006006 ! glucose metabolic process
is_a: GO:0019319 ! hexose biosynthetic process

[Term]
id: GO:0006096
name: glycolytic process
namespace: biological_process
alt_id: GO:0019641
alt_id: GO:0019642
def: "The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]
subset: gosubset_prok
synonym: "anaerobic glycolysis" RELATED []
synonym: "Embden-Meyerhof pathway" RELATED []
synonym: "Embden-Meyerhof-Parnas pathway" RELATED []
synonym: "glycolysis" RELATED [GOC:dph]
synonym: "modifed Embden-Meyerhof pathway" RELATED []
xref: MetaCyc:GLYCOLYSIS-VARIANTS
is_a: GO:0006090 ! pyruvate metabolic process
is_a: GO:0006757 ! ATP generation from ADP
is_a: GO:0044724 ! single-organism carbohydrate catabolic process
is_a: GO:0046496 ! nicotinamide nucleotide metabolic process
relationship: has_part GO:0004618 ! phosphoglycerate kinase activity
relationship: has_part GO:0004619 ! phosphoglycerate mutase activity
relationship: has_part GO:0004634 ! phosphopyruvate hydratase activity
relationship: has_part GO:0043891 ! glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity

[Term]
id: GO:0006097
name: glyoxylate cycle
namespace: biological_process
def: "A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate." [ISBN:0198506732]
subset: gosubset_prok
synonym: "glyoxylate bypass" EXACT []
xref: MetaCyc:GLYOXYLATE-BYPASS
xref: Wikipedia:Glyoxylate_cycle
is_a: GO:0044262 ! cellular carbohydrate metabolic process
is_a: GO:0044723 ! single-organism carbohydrate metabolic process
is_a: GO:0046487 ! glyoxylate metabolic process

[Term]
id: GO:0006098
name: pentose-phosphate shunt
namespace: biological_process
def: "The glucose-6-phosphate catabolic process in which, coupled to NADPH synthesis, glucose-6-P is oxidized with the formation of carbon dioxide (CO2) and ribulose 5-phosphate; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses." [ISBN:0198506732, MetaCyc:PENTOSE-P-PWY]
subset: gosubset_prok
synonym: "hexose monophosphate pathway" EXACT []
synonym: "pentose phosphate pathway" EXACT []
synonym: "pentose phosphate shunt" EXACT []
synonym: "pentose-phosphate pathway" EXACT []
xref: KEGG_PATHWAY:00030
xref: MetaCyc:PENTOSE-P-PWY
xref: Reactome:R-HSA-71336 "Pentose phosphate pathway (hexose monophosphate shunt), Homo sapiens"
xref: Wikipedia:Pentose_phosphate_pathway
is_a: GO:0006739 ! NADP metabolic process
is_a: GO:0019682 ! glyceraldehyde-3-phosphate metabolic process
is_a: GO:0019693 ! ribose phosphate metabolic process
is_a: GO:0051156 ! glucose 6-phosphate metabolic process

[Term]
id: GO:0006099
name: tricarboxylic acid cycle
namespace: biological_process
def: "A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]
subset: gosubset_prok
synonym: "citric acid cycle" EXACT []
synonym: "Krebs cycle" EXACT []
synonym: "TCA cycle" EXACT []
xref: MetaCyc:P105-PWY
xref: MetaCyc:P42-PWY
xref: MetaCyc:TCA
xref: Reactome:REACT_101296 "Citric acid cycle (TCA cycle), Oryza sativa"
xref: Reactome:REACT_101797 "Citric acid cycle (TCA cycle), Taeniopygia guttata"
xref: Reactome:REACT_105180 "Citric acid cycle (TCA cycle), Canis familiaris"
xref: Reactome:REACT_110534 "Citric acid cycle (TCA cycle), Xenopus tropicalis"
xref: Reactome:REACT_110779 "Citric acid cycle (TCA cycle), Danio rerio"
xref: Reactome:REACT_115536 "The tricarboxylic acid cycle, Gallus gallus"
xref: Reactome:REACT_1785 "Citric acid cycle (TCA cycle), Homo sapiens"
xref: Reactome:REACT_33923 "Citric acid cycle (TCA cycle), Plasmodium falciparum"
xref: Reactome:REACT_54425 "Citric acid cycle (TCA cycle), Schizosaccharomyces pombe"
xref: Reactome:REACT_81042 "Citric acid cycle (TCA cycle), Saccharomyces cerevisiae"
xref: Reactome:REACT_82509 "Citric acid cycle (TCA cycle), Bos taurus"
xref: Reactome:REACT_82906 "Citric acid cycle (TCA cycle), Dictyostelium discoideum"
xref: Reactome:REACT_83116 "Citric acid cycle (TCA cycle), Drosophila melanogaster"
xref: Reactome:REACT_83923 "Citric acid cycle (TCA cycle), Mus musculus"
xref: Reactome:REACT_84181 "Citric acid cycle (TCA cycle), Staphylococcus aureus N315"
xref: Reactome:REACT_85849 "Citric acid cycle (TCA cycle), Arabidopsis thaliana"
xref: Reactome:REACT_89038 "Citric acid cycle (TCA cycle), Sus scrofa"
xref: Reactome:REACT_89851 "Citric acid cycle (TCA cycle), Rattus norvegicus"
xref: Reactome:REACT_90664 "Citric acid cycle (TCA cycle), Escherichia coli"
xref: Reactome:REACT_94857 "Citric acid cycle (TCA cycle), Gallus gallus"
xref: Reactome:REACT_98104 "Citric acid cycle (TCA cycle), Caenorhabditis elegans"
xref: Reactome:REACT_98794 "Citric acid cycle (TCA cycle), Mycobacterium tuberculosis"
xref: Wikipedia:Tricarboxylic_acid_cycle
is_a: GO:0006101 ! citrate metabolic process
is_a: GO:0044238 ! primary metabolic process
relationship: part_of GO:0009060 ! aerobic respiration

[Term]
id: GO:0006100
name: obsolete tricarboxylic acid cycle intermediate metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving intermediates of the tricarboxylic acid cycle." [GOC:ai]
comment: This term was made obsolete because it is a grouping term that is not useful, but has caused true path violations.
synonym: "citric acid cycle intermediate metabolic process" EXACT []
synonym: "citric acid cycle intermediate metabolism" EXACT []
synonym: "Krebs cycle intermediate metabolic process" EXACT []
synonym: "Krebs cycle intermediate metabolism" EXACT []
synonym: "TCA intermediate metabolic process" EXACT []
synonym: "TCA intermediate metabolism" EXACT []
synonym: "tricarboxylic acid cycle intermediate metabolic process" EXACT []
synonym: "tricarboxylic acid cycle intermediate metabolism" EXACT []
is_obsolete: true
consider: GO:0006099
consider: GO:0006101
consider: GO:0006103
consider: GO:0006104
consider: GO:0006105
consider: GO:0006106
consider: GO:0006107
consider: GO:0006108

[Term]
id: GO:0006101
name: citrate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving citrate, 2-hydroxy-1,2,3-propanetricarboyxlate. Citrate is widely distributed in nature and is an important intermediate in the TCA cycle and the glyoxylate cycle." [ISBN:0198506732]
subset: gosubset_prok
synonym: "citrate metabolism" EXACT []
is_a: GO:0072350 ! tricarboxylic acid metabolic process

[Term]
id: GO:0006102
name: isocitrate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving isocitrate, the anion of isocitric acid, 1-hydroxy-1,2,3-propanetricarboxylic acid. Isocitrate is an important intermediate in the TCA cycle and the glycoxylate cycle." [ISBN:0198506732]
subset: gosubset_prok
synonym: "isocitrate metabolism" EXACT []
is_a: GO:0072350 ! tricarboxylic acid metabolic process

[Term]
id: GO:0006103
name: 2-oxoglutarate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism." [ISBN:0198506732]
subset: gosubset_prok
synonym: "2-ketoglutarate metabolic process" EXACT []
synonym: "2-ketoglutarate metabolism" EXACT []
synonym: "2-oxoglutarate metabolism" EXACT []
synonym: "alpha-ketoglutarate metabolic process" EXACT []
synonym: "alpha-ketoglutarate metabolism" EXACT []
synonym: "alpha-oxoglutarate metabolic process" EXACT []
synonym: "alpha-oxoglutarate metabolism" EXACT []
xref: Reactome:REACT_25367 "Interconversion of 2-oxoglutarate and 2-hydroxyglutarate, Homo sapiens"
is_a: GO:0043648 ! dicarboxylic acid metabolic process

[Term]
id: GO:0006104
name: succinyl-CoA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving succinyl-CoA, a compound composed of the monovalent acyl group 3-carboxypropanoyl, derived from succinic acid by loss of one OH group, linked to coenzyme A." [GOC:ai]
subset: gosubset_prok
synonym: "succinyl-CoA metabolism" EXACT []
is_a: GO:0006637 ! acyl-CoA metabolic process

[Term]
id: GO:0006105
name: succinate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving succinate, also known as butanedioate or ethane dicarboxylate, the dianion of succinic acid. Succinate is an important intermediate in metabolism and a component of the TCA cycle." [ISBN:0198506732]
subset: gosubset_prok
synonym: "succinate metabolism" EXACT []
is_a: GO:0043648 ! dicarboxylic acid metabolic process

[Term]
id: GO:0006106
name: fumarate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fumarate, the anion of trans-1,2-ethenedicarboxylic acid, the diastereoisomer of maleate. It is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate." [ISBN:0198506732]
subset: gosubset_prok
synonym: "fumarate metabolism" EXACT []
is_a: GO:0043648 ! dicarboxylic acid metabolic process

[Term]
id: GO:0006107
name: oxaloacetate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving oxaloacetate, the anion of oxobutanedioic acid, an important intermediate in metabolism, especially as a component of the TCA cycle." [ISBN:0198506732]
subset: gosubset_prok
synonym: "oxaloacetate metabolism" EXACT []
is_a: GO:0043648 ! dicarboxylic acid metabolic process

[Term]
id: GO:0006108
name: malate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle." [ISBN:0198506732]
subset: gosubset_prok
synonym: "malate metabolism" EXACT []
is_a: GO:0043648 ! dicarboxylic acid metabolic process

[Term]
id: GO:0006109
name: regulation of carbohydrate metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of carbohydrate metabolism" EXACT []
is_a: GO:0080090 ! regulation of primary metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0005975 ! carbohydrate metabolic process
relationship: regulates GO:0005975 ! carbohydrate metabolic process

[Term]
id: GO:0006110
name: regulation of glycolytic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glycolysis." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0030811 ! regulation of nucleotide catabolic process
is_a: GO:0042325 ! regulation of phosphorylation
is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy
is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process
is_a: GO:0051196 ! regulation of coenzyme metabolic process
is_a: GO:1903578 ! regulation of ATP metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006096 ! glycolytic process
relationship: regulates GO:0006096 ! glycolytic process

[Term]
id: GO:0006111
name: regulation of gluconeogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gluconeogenesis, the formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of glucose biosynthesis" BROAD []
synonym: "regulation of glucose biosynthetic process" BROAD []
is_a: GO:0010906 ! regulation of glucose metabolic process
is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006094 ! gluconeogenesis
relationship: regulates GO:0006094 ! gluconeogenesis

[Term]
id: GO:0006112
name: energy reserve metabolic process
namespace: biological_process
def: "The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen." [GOC:mah]
subset: goslim_pir
subset: gosubset_prok
synonym: "energy reserve metabolism" EXACT []
xref: Reactome:REACT_100070 "Integration of energy metabolism, Taeniopygia guttata"
xref: Reactome:REACT_105810 "Integration of energy metabolism, Mus musculus"
xref: Reactome:REACT_108807 "Integration of energy metabolism, Plasmodium falciparum"
xref: Reactome:REACT_109211 "Integration of energy metabolism, Arabidopsis thaliana"
xref: Reactome:REACT_110910 "Integration of energy metabolism, Rattus norvegicus"
xref: Reactome:REACT_1505 "Integration of energy metabolism, Homo sapiens"
xref: Reactome:REACT_28839 "Integration of energy metabolism, Dictyostelium discoideum"
xref: Reactome:REACT_31409 "Integration of energy metabolism, Caenorhabditis elegans"
xref: Reactome:REACT_33977 "Integration of energy metabolism, Xenopus tropicalis"
xref: Reactome:REACT_77410 "Integration of energy metabolism, Bos taurus"
xref: Reactome:REACT_79340 "Integration of energy metabolism, Escherichia coli"
xref: Reactome:REACT_80356 "Integration of energy metabolism, Canis familiaris"
xref: Reactome:REACT_83420 "Integration of energy metabolism, Mycobacterium tuberculosis"
xref: Reactome:REACT_85294 "Integration of energy metabolism, Danio rerio"
xref: Reactome:REACT_87289 "Integration of energy metabolism, Saccharomyces cerevisiae"
xref: Reactome:REACT_88950 "Integration of energy metabolism, Staphylococcus aureus N315"
xref: Reactome:REACT_89538 "Integration of energy metabolism, Drosophila melanogaster"
xref: Reactome:REACT_93425 "Integration of energy metabolism, Oryza sativa"
xref: Reactome:REACT_94255 "Integration of energy metabolism, Gallus gallus"
xref: Reactome:REACT_94635 "Integration of energy metabolism, Schizosaccharomyces pombe"
xref: Reactome:REACT_98844 "Integration of energy metabolism, Sus scrofa"
is_a: GO:0015980 ! energy derivation by oxidation of organic compounds

[Term]
id: GO:0006113
name: fermentation
namespace: biological_process
def: "The anaerobic enzymatic conversion of organic compounds, especially carbohydrates, coupling the oxidation and reduction of NAD/H and the generation of adenosine triphosphate (ATP)." [GOC:curators, ISBN:0201090910, ISBN:124925502, MetaCyc:Fermentation]
subset: goslim_pir
subset: gosubset_prok
xref: MetaCyc:FERMENTATION-PWY
xref: Wikipedia:Fermentation_(biochemistry)
is_a: GO:0015980 ! energy derivation by oxidation of organic compounds

[Term]
id: GO:0006114
name: glycerol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai, ISBN:0198506732]
subset: gosubset_prok
synonym: "glycerol anabolism" EXACT []
synonym: "glycerol biosynthesis" EXACT []
synonym: "glycerol formation" EXACT []
synonym: "glycerol synthesis" EXACT []
is_a: GO:0006071 ! glycerol metabolic process
is_a: GO:0019401 ! alditol biosynthetic process

[Term]
id: GO:0006115
name: ethanol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation." [GOC:ai, ISBN:0198506732]
subset: gosubset_prok
synonym: "ethanol anabolism" EXACT []
synonym: "ethanol biosynthesis" EXACT []
synonym: "ethanol formation" EXACT []
synonym: "ethanol synthesis" EXACT []
is_a: GO:0006067 ! ethanol metabolic process
is_a: GO:0034309 ! primary alcohol biosynthetic process

[Term]
id: GO:0006116
name: NADH oxidation
namespace: biological_process
def: "A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADH, to the oxidized form, NAD." [GOC:ai]
subset: gosubset_prok
synonym: "NAD (reduced) dehydrogenation" EXACT []
synonym: "NAD (reduced) oxidation" EXACT []
synonym: "NADH dehydrogenation" EXACT []
synonym: "reduced NAD dehydrogenation" EXACT []
synonym: "reduced NAD oxidation" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide dehydrogenation" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide oxidation" EXACT []
is_a: GO:0006734 ! NADH metabolic process
is_a: GO:0055114 ! oxidation-reduction process

[Term]
id: GO:0006117
name: acetaldehyde metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving acetaldehyde, a colorless, flammable liquid intermediate in the metabolism of alcohol." [CHEBI:15343, GOC:go_curators]
subset: gosubset_prok
synonym: "acetaldehyde metabolism" EXACT []
synonym: "ethanal metabolic process" EXACT []
synonym: "ethanal metabolism" EXACT []
is_a: GO:0006081 ! cellular aldehyde metabolic process

[Term]
id: GO:0006118
name: obsolete electron transport
namespace: biological_process
def: "OBSOLETE. The transport of electrons from an electron donor to an electron acceptor." [GOC:curators]
comment: This term was made obsolete because it describes a molecular function.
synonym: "6-phosphofructokinase reduction" RELATED []
synonym: "dihydrobiopterin reduction" RELATED []
synonym: "dihydrolipoamide reduction" RELATED []
synonym: "dihydrolipoylprotein reduction" RELATED []
synonym: "dihydropteridine reduction" RELATED []
synonym: "electron transfer" EXACT []
synonym: "electron transport" EXACT []
synonym: "other pathways of electron transport" RELATED []
synonym: "oxidized glutathione reduction" RELATED []
synonym: "protein-disulfide reduction" RELATED []
is_obsolete: true
replaced_by: GO:0055114
consider: GO:0016491
consider: GO:0022904

[Term]
id: GO:0006119
name: oxidative phosphorylation
namespace: biological_process
def: "The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis." [ISBN:0198506732, ISBN:0471331309]
subset: goslim_pir
subset: gosubset_prok
synonym: "respiratory-chain phosphorylation" EXACT []
xref: Wikipedia:Oxidative_phosphorylation
is_a: GO:0006091 ! generation of precursor metabolites and energy
is_a: GO:0016310 ! phosphorylation
is_a: GO:0046034 ! ATP metabolic process
relationship: has_part GO:0015986 ! ATP synthesis coupled proton transport

[Term]
id: GO:0006120
name: mitochondrial electron transport, NADH to ubiquinone
namespace: biological_process
def: "The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I." [ISBN:0716731363]
synonym: "complex I (NADH to ubiquinone)" RELATED []
synonym: "oxidative phosphorylation, NADH to ubiquinone" EXACT []
xref: Reactome:REACT_102400 "NADH enters the respiratory chain at Complex I, Gallus gallus"
xref: Reactome:REACT_33391 "NADH enters the respiratory chain at Complex I, Rattus norvegicus"
xref: Reactome:REACT_6310 "NADH enters the respiratory chain at Complex I, Homo sapiens"
xref: Reactome:REACT_81770 "NADH enters the respiratory chain at Complex I, Canis familiaris"
xref: Reactome:REACT_81943 "NADH enters the respiratory chain at Complex I, Mus musculus"
xref: Reactome:REACT_84378 "NADH enters the respiratory chain at Complex I, Bos taurus"
xref: Reactome:REACT_86959 "NADH enters the respiratory chain at Complex I, Danio rerio"
xref: Reactome:REACT_96903 "NADH enters the respiratory chain at Complex I, Sus scrofa"
xref: Reactome:REACT_98202 "NADH enters the respiratory chain at Complex I, Drosophila melanogaster"
is_a: GO:0022904 ! respiratory electron transport chain
relationship: part_of GO:0042775 ! mitochondrial ATP synthesis coupled electron transport

[Term]
id: GO:0006121
name: mitochondrial electron transport, succinate to ubiquinone
namespace: biological_process
def: "The transfer of electrons from succinate to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex II." [ISBN:0716731363]
synonym: "complex II (succinate to ubiquinone)" RELATED []
synonym: "mitochondrial electron transport, succinate to coenzyme Q" EXACT []
synonym: "oxidative phosphorylation, succinate to ubiquinone" EXACT []
xref: Reactome:REACT_103505 "Transfer of electrons through the succinate dehydrogenase complex, Danio rerio"
xref: Reactome:REACT_6292 "Transfer of electrons through the bovine succinate dehydrogenase complex, Bos taurus"
xref: Reactome:REACT_6360 "Transfer of electrons through the succinate dehydrogenase complex, Homo sapiens"
xref: Reactome:REACT_80248 "Transfer of electrons through the succinate dehydrogenase complex, Schizosaccharomyces pombe"
xref: Reactome:REACT_83108 "Transfer of electrons through the succinate dehydrogenase complex, Caenorhabditis elegans"
xref: Reactome:REACT_84221 "Transfer of electrons through the succinate dehydrogenase complex, Canis familiaris"
xref: Reactome:REACT_88562 "Transfer of electrons through the succinate dehydrogenase complex, Saccharomyces cerevisiae"
xref: Reactome:REACT_88611 "Transfer of electrons through the succinate dehydrogenase complex, Drosophila melanogaster"
xref: Reactome:REACT_90176 "Transfer of electrons through the succinate dehydrogenase complex, Taeniopygia guttata"
xref: Reactome:REACT_92395 "Transfer of electrons through the succinate dehydrogenase complex, Mus musculus"
xref: Reactome:REACT_92514 "Transfer of electrons through the succinate dehydrogenase complex, Xenopus tropicalis"
xref: Reactome:REACT_97027 "Transfer of electrons through the succinate dehydrogenase complex, Rattus norvegicus"
xref: Reactome:REACT_98347 "Transfer of electrons through the succinate dehydrogenase complex, Gallus gallus"
xref: Reactome:REACT_99727 "Transfer of electrons through the succinate dehydrogenase complex, Dictyostelium discoideum"
is_a: GO:0022904 ! respiratory electron transport chain
relationship: part_of GO:0042775 ! mitochondrial ATP synthesis coupled electron transport

[Term]
id: GO:0006122
name: mitochondrial electron transport, ubiquinol to cytochrome c
namespace: biological_process
def: "The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III." [ISBN:0716731363]
synonym: "complex III (ubiquinone to cytochrome c)" RELATED []
xref: Reactome:REACT_112720 "Electron transfer from ubiquinol to cytochrome c of complex III, Canis familiaris"
xref: Reactome:REACT_112947 "Electron transfer from ubiquinol to cytochrome c of complex III, Drosophila melanogaster"
xref: Reactome:REACT_113468 "Electron transfer from ubiquinol to cytochrome c of complex III, Rattus norvegicus"
xref: Reactome:REACT_113728 "Electron transfer from ubiquinol to cytochrome c of complex III, Bos taurus"
xref: Reactome:REACT_115341 "Electron transfer from ubiquinol to cytochrome c of complex III, Sus scrofa"
xref: Reactome:REACT_6300 "Electron transfer from ubiquinol to cytochrome c of complex III, Homo sapiens"
xref: Reactome:REACT_79763 "Electron transfer from ubiquinol to cytochrome c of complex III, Taeniopygia guttata"
xref: Reactome:REACT_89051 "Electron transfer from ubiquinol to cytochrome c of complex III, Danio rerio"
xref: Reactome:REACT_93718 "Electron transfer from ubiquinol to cytochrome c of complex III, Gallus gallus"
xref: Reactome:REACT_98829 "Electron transfer from ubiquinol to cytochrome c of complex III, Mus musculus"
is_a: GO:0022904 ! respiratory electron transport chain
relationship: part_of GO:0042775 ! mitochondrial ATP synthesis coupled electron transport

[Term]
id: GO:0006123
name: mitochondrial electron transport, cytochrome c to oxygen
namespace: biological_process
def: "The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV." [ISBN:0716731363]
synonym: "complex IV (reduction of O2)" RELATED []
xref: Reactome:REACT_113276 "Electron transfer from reduced cytochrome c to molecular oxygen, Bos taurus"
xref: Reactome:REACT_113311 "Electron transfer from reduced cytochrome c to molecular oxygen, Sus scrofa"
xref: Reactome:REACT_113736 "Electron transfer from reduced cytochrome c to molecular oxygen, Canis familiaris"
xref: Reactome:REACT_115027 "Electron transfer from reduced cytochrome c to molecular oxygen, Rattus norvegicus"
xref: Reactome:REACT_33608 "Electron transfer from reduced cytochrome c to molecular oxygen, Danio rerio"
xref: Reactome:REACT_6149 "Electron transfer from reduced cytochrome c to molecular oxygen, Homo sapiens"
xref: Reactome:REACT_78871 "Electron transfer from reduced cytochrome c to molecular oxygen, Gallus gallus"
xref: Reactome:REACT_99789 "Electron transfer from reduced cytochrome c to molecular oxygen, Mus musculus"
is_a: GO:0022904 ! respiratory electron transport chain
relationship: part_of GO:0042775 ! mitochondrial ATP synthesis coupled electron transport

[Term]
id: GO:0006124
name: ferredoxin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ferredoxin, any simple, nonenzymatic iron-sulfur protein that is characterized by having equal numbers of atoms of iron and labile sulfur. Iron and sulfur atoms are present in one or two clusters of two or four atoms of each." [ISBN:0198506732]
subset: gosubset_prok
synonym: "ferredoxin metabolism" EXACT []
is_a: GO:0044267 ! cellular protein metabolic process

[Term]
id: GO:0006125
name: obsolete thioredoxin pathway
namespace: biological_process
def: "OBSOLETE." [GOC:mtg_electron_transport]
comment: This term was made obsolete because it is not clear what it is intended to represent.
synonym: "thioredoxin pathway" EXACT []
synonym: "thioredoxin reduction" NARROW []
xref: MetaCyc:THIOREDOX-PWY
is_obsolete: true
consider: GO:0045454

[Term]
id: GO:0006126
name: obsolete other pathways of electron transport
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "other pathways of electron transport" EXACT []
is_obsolete: true
replaced_by: GO:0022900

[Term]
id: GO:0006127
name: glycerophosphate shuttle
namespace: biological_process
def: "The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise glycerol 3-phosphate in the cytosol; this compound is then transported into the mitochondria where it is converted to dihydroxyacetone phosphate (DHAP) using FAD; DHAP then returns to the cytosol to complete the cycle." [GOC:jl, GOC:mtg_electron_transport, ISBN:071672009, PMID:16368075]
subset: gosubset_prok
xref: MetaCyc:PWY-6118
is_a: GO:0006116 ! NADH oxidation
is_a: GO:0042180 ! cellular ketone metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process
relationship: has_part GO:0004367 ! glycerol-3-phosphate dehydrogenase [NAD+] activity
relationship: has_part GO:0052590 ! sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity
relationship: part_of GO:0022904 ! respiratory electron transport chain

[Term]
id: GO:0006128
name: obsolete oxidized glutathione reduction
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because the term string represents a molecular function and not a biological pathway.
synonym: "oxidized glutathione reduction" EXACT []
is_obsolete: true
consider: GO:0004362
consider: GO:0006749
consider: GO:0022900

[Term]
id: GO:0006129
name: obsolete protein-disulfide reduction
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function rather than a biological process.
synonym: "protein-disulfide reduction" EXACT []
synonym: "protein-disulphide reduction" EXACT []
is_obsolete: true
consider: GO:0019153
consider: GO:0022900

[Term]
id: GO:0006130
name: obsolete 6-phosphofructokinase reduction
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because the term string was ambiguous and the term may represent a molecular function.
synonym: "6-phosphofructokinase reduction" EXACT []
is_obsolete: true
consider: GO:0003872
consider: GO:0022900

[Term]
id: GO:0006131
name: obsolete dihydrolipoamide reduction
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function rather than a biological process.
synonym: "dihydrolipoamide reduction" EXACT []
is_obsolete: true
consider: GO:0004148
consider: GO:0022900
consider: GO:0051068

[Term]
id: GO:0006132
name: obsolete dihydrolipoylprotein reduction
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function rather than a biological process.
synonym: "dihydrolipoylprotein reduction" EXACT []
is_obsolete: true
consider: GO:0004148
consider: GO:0022900

[Term]
id: GO:0006133
name: obsolete 5,10-methylenetetrahydrofolate oxidation
namespace: biological_process
def: "OBSOLETE." [GOC:mtg_electron_transport]
comment: This term was made obsolete because it is defined as a function term and is in the process ontology.
synonym: "5,10-methylenetetrahydrofolate oxidation" EXACT []
is_obsolete: true
consider: GO:0004487
consider: GO:0004488
consider: GO:0004489
consider: GO:0033738

[Term]
id: GO:0006134
name: obsolete dihydrobiopterin reduction
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function rather than a biological process.
synonym: "dihydrobiopterin reduction" EXACT []
is_obsolete: true
consider: GO:0022900
consider: GO:0047040
consider: GO:0051066

[Term]
id: GO:0006135
name: obsolete dihydropteridine reduction
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function rather than a biological process.
synonym: "dihydropteridine reduction" EXACT []
is_obsolete: true
consider: GO:0004155
consider: GO:0022900
consider: GO:0051067

[Term]
id: GO:0006139
name: nucleobase-containing compound metabolic process
namespace: biological_process
alt_id: GO:0055134
def: "Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT []
synonym: "cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT []
synonym: "nucleobase, nucleoside and nucleotide metabolic process" RELATED []
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" RELATED [GOC:dph, GOC:tb]
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT []
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0034641 ! cellular nitrogen compound metabolic process
is_a: GO:0044238 ! primary metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process

[Term]
id: GO:0006140
name: regulation of nucleotide metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleotides." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of nucleotide metabolism" EXACT []
is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process
is_a: GO:0019220 ! regulation of phosphate metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009117 ! nucleotide metabolic process
relationship: regulates GO:0009117 ! nucleotide metabolic process

[Term]
id: GO:0006141
name: regulation of purine nucleobase metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving purines." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of purine base metabolic process" EXACT [GOC:go_curators]
synonym: "regulation of purine base metabolism" EXACT []
is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006144 ! purine nucleobase metabolic process
relationship: regulates GO:0006144 ! purine nucleobase metabolic process

[Term]
id: GO:0006142
name: regulation of pyrimidine nucleobase metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving pyrimidine nucleobases." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of pyrimidine base metabolic process" EXACT [GOC:go_curators]
synonym: "regulation of pyrimidine base metabolism" EXACT []
is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006206 ! pyrimidine nucleobase metabolic process
relationship: regulates GO:0006206 ! pyrimidine nucleobase metabolic process

[Term]
id: GO:0006143
name: obsolete purine metabolic process
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because more appropriate terms were created.
synonym: "purine metabolic process" EXACT []
is_obsolete: true
consider: GO:0006144
consider: GO:0006163
consider: GO:0042278

[Term]
id: GO:0006144
name: purine nucleobase metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." [CHEBI:26386, GOC:go_curators]
subset: gosubset_prok
synonym: "purine base metabolic process" EXACT [GOC:go_curators]
synonym: "purine base metabolism" EXACT []
synonym: "purine metabolic process" NARROW []
synonym: "purine metabolism" NARROW []
xref: Reactome:REACT_101087 "Purine metabolism, Dictyostelium discoideum"
xref: Reactome:REACT_105087 "Purine metabolism, Danio rerio"
xref: Reactome:REACT_108194 "Purine metabolism, Escherichia coli"
xref: Reactome:REACT_110082 "Purine metabolism, Drosophila melanogaster"
xref: Reactome:REACT_110843 "Purine metabolism, Gallus gallus"
xref: Reactome:REACT_115917 "Purine metabolism, Gallus gallus"
xref: Reactome:REACT_29411 "Purine metabolism, Rattus norvegicus"
xref: Reactome:REACT_522 "Purine metabolism, Homo sapiens"
xref: Reactome:REACT_77529 "Purine metabolism, Canis familiaris"
xref: Reactome:REACT_79349 "Purine metabolism, Taeniopygia guttata"
xref: Reactome:REACT_80519 "Purine metabolism, Sus scrofa"
xref: Reactome:REACT_82939 "Purine metabolism, Plasmodium falciparum"
xref: Reactome:REACT_84284 "Purine metabolism, Staphylococcus aureus N315"
xref: Reactome:REACT_86750 "Purine metabolism, Bos taurus"
xref: Reactome:REACT_86895 "Purine metabolism, Xenopus tropicalis"
xref: Reactome:REACT_87509 "Purine metabolism, Saccharomyces cerevisiae"
xref: Reactome:REACT_87690 "Purine metabolism, Oryza sativa"
xref: Reactome:REACT_90193 "Purine metabolism, Caenorhabditis elegans"
xref: Reactome:REACT_91779 "Purine metabolism, Arabidopsis thaliana"
xref: Reactome:REACT_91974 "Purine metabolism, Schizosaccharomyces pombe"
xref: Reactome:REACT_92400 "Purine metabolism, Mus musculus"
xref: Reactome:REACT_98747 "Purine metabolism, Mycobacterium tuberculosis"
is_a: GO:0009112 ! nucleobase metabolic process
is_a: GO:0072521 ! purine-containing compound metabolic process

[Term]
id: GO:0006145
name: purine nucleobase catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." [GOC:go_curators]
subset: gosubset_prok
synonym: "purine base breakdown" EXACT []
synonym: "purine base catabolic process" EXACT [GOC:go_curators]
synonym: "purine base catabolism" EXACT []
synonym: "purine base degradation" EXACT []
is_a: GO:0006144 ! purine nucleobase metabolic process
is_a: GO:0046113 ! nucleobase catabolic process
is_a: GO:0072523 ! purine-containing compound catabolic process

[Term]
id: GO:0006146
name: adenine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of adenine, 6-aminopurine, one of the 5 main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine." [ISBN:0198506732]
subset: gosubset_prok
synonym: "adenine breakdown" EXACT []
synonym: "adenine catabolism" EXACT []
synonym: "adenine degradation" EXACT []
is_a: GO:0006145 ! purine nucleobase catabolic process
is_a: GO:0046083 ! adenine metabolic process

[Term]
id: GO:0006147
name: guanine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important." [GOC:go_curators]
subset: gosubset_prok
synonym: "guanine breakdown" EXACT []
synonym: "guanine catabolism" EXACT []
synonym: "guanine degradation" EXACT []
is_a: GO:0006145 ! purine nucleobase catabolic process
is_a: GO:0046098 ! guanine metabolic process

[Term]
id: GO:0006148
name: inosine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs." [GOC:go_curators]
subset: gosubset_prok
synonym: "inosine breakdown" EXACT []
synonym: "inosine catabolism" EXACT []
synonym: "inosine degradation" EXACT []
is_a: GO:0046102 ! inosine metabolic process
is_a: GO:0046130 ! purine ribonucleoside catabolic process

[Term]
id: GO:0006149
name: deoxyinosine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of deoxyinosine, hypoxanthine deoxyriboside." [GOC:go_curators]
subset: gosubset_prok
synonym: "deoxyinosine breakdown" EXACT []
synonym: "deoxyinosine catabolism" EXACT []
synonym: "deoxyinosine degradation" EXACT []
is_a: GO:0046094 ! deoxyinosine metabolic process
is_a: GO:0046124 ! purine deoxyribonucleoside catabolic process

[Term]
id: GO:0006150
name: hypoxanthine oxidation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of hypoxanthine to xanthine and thence to uric acid." [GOC:mah, PMID:3196295]
subset: gosubset_prok
is_a: GO:0009114 ! hypoxanthine catabolic process
is_a: GO:0055114 ! oxidation-reduction process

[Term]
id: GO:0006151
name: xanthine oxidation
namespace: biological_process
def: "The oxidation of xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids." [GOC:jl]
subset: gosubset_prok
is_a: GO:0009115 ! xanthine catabolic process
is_a: GO:0055114 ! oxidation-reduction process

[Term]
id: GO:0006152
name: purine nucleoside catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:go_curators]
subset: gosubset_prok
synonym: "purine nucleoside breakdown" EXACT []
synonym: "purine nucleoside catabolism" EXACT []
synonym: "purine nucleoside degradation" EXACT []
is_a: GO:0009164 ! nucleoside catabolic process
is_a: GO:0042278 ! purine nucleoside metabolic process
is_a: GO:0072523 ! purine-containing compound catabolic process

[Term]
id: GO:0006153
name: obsolete purine nucleosidase reaction
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function.
synonym: "purine nucleosidase reaction" EXACT []
is_obsolete: true
replaced_by: GO:0008477

[Term]
id: GO:0006154
name: adenosine catabolic process
namespace: biological_process
alt_id: GO:0006156
def: "The chemical reactions and pathways resulting in the breakdown of adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes." [GOC:go_curators]
subset: gosubset_prok
synonym: "adenosine breakdown" EXACT []
synonym: "adenosine catabolism" EXACT []
synonym: "adenosine degradation" EXACT []
synonym: "adenosine phosphorolysis" RELATED []
is_a: GO:0046085 ! adenosine metabolic process
is_a: GO:0046130 ! purine ribonucleoside catabolic process

[Term]
id: GO:0006155
name: obsolete adenosine deaminase reaction
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function.
synonym: "adenosine deaminase reaction" EXACT []
is_obsolete: true
replaced_by: GO:0004000

[Term]
id: GO:0006157
name: deoxyadenosine catabolic process
namespace: biological_process
alt_id: GO:0006159
def: "The chemical reactions and pathways resulting in the breakdown of deoxyadenosine, 2-deoxyribosyladenine, one of the four major nucleosides of DNA." [GOC:go_curators]
subset: gosubset_prok
synonym: "deoxyadenosine breakdown" EXACT []
synonym: "deoxyadenosine catabolism" EXACT []
synonym: "deoxyadenosine degradation" EXACT []
synonym: "deoxyadenosine phosphorolysis" RELATED []
is_a: GO:0046090 ! deoxyadenosine metabolic process
is_a: GO:0046124 ! purine deoxyribonucleoside catabolic process

[Term]
id: GO:0006158
name: obsolete deoxyadenosine deaminase reaction
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function.
synonym: "deoxyadenosine deaminase reaction" EXACT []
is_obsolete: true
replaced_by: GO:0046936

[Term]
id: GO:0006161
name: deoxyguanosine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of deoxyguanosine, a nucleoside consisting of the base guanine and the sugar deoxyribose." [CHEBI:17172, GOC:jl]
subset: gosubset_prok
synonym: "deoxyguanosine breakdown" EXACT []
synonym: "deoxyguanosine catabolism" EXACT []
synonym: "deoxyguanosine degradation" EXACT []
is_a: GO:0042453 ! deoxyguanosine metabolic process
is_a: GO:0046124 ! purine deoxyribonucleoside catabolic process

[Term]
id: GO:0006162
name: obsolete purine/pyrimidine nucleoside diphosphate reduction
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function rather than a biological process.
synonym: "purine/pyrimidine nucleoside diphosphate reduction" EXACT []
is_obsolete: true
consider: GO:0004748

[Term]
id: GO:0006163
name: purine nucleotide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "purine metabolic process" NARROW []
synonym: "purine metabolism" NARROW []
synonym: "purine nucleotide metabolism" EXACT []
is_a: GO:0009117 ! nucleotide metabolic process
is_a: GO:0072521 ! purine-containing compound metabolic process

[Term]
id: GO:0006164
name: purine nucleotide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "purine nucleotide anabolism" EXACT []
synonym: "purine nucleotide biosynthesis" EXACT []
synonym: "purine nucleotide formation" EXACT []
synonym: "purine nucleotide synthesis" EXACT []
xref: MetaCyc:DENOVOPURINE2-PWY
is_a: GO:0006163 ! purine nucleotide metabolic process
is_a: GO:0009165 ! nucleotide biosynthetic process
is_a: GO:0072522 ! purine-containing compound biosynthetic process

[Term]
id: GO:0006165
name: nucleoside diphosphate phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group into a nucleoside diphosphate to produce a nucleoside triphosphate." [GOC:ai]
subset: gosubset_prok
is_a: GO:0009132 ! nucleoside diphosphate metabolic process
is_a: GO:0046939 ! nucleotide phosphorylation

[Term]
id: GO:0006166
name: purine ribonucleoside salvage
namespace: biological_process
def: "Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis." [GOC:jl]
subset: gosubset_prok
xref: MetaCyc:P121-PWY
is_a: GO:0043101 ! purine-containing compound salvage
is_a: GO:0043174 ! nucleoside salvage
is_a: GO:0046129 ! purine ribonucleoside biosynthetic process

[Term]
id: GO:0006167
name: AMP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of AMP, adenosine monophosphate." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "AMP anabolism" EXACT []
synonym: "AMP biosynthesis" EXACT []
synonym: "AMP formation" EXACT []
synonym: "AMP synthesis" EXACT []
xref: Reactome:REACT_115540 "De novo synthesis of AMP, Gallus gallus"
is_a: GO:0009152 ! purine ribonucleotide biosynthetic process
is_a: GO:0009168 ! purine ribonucleoside monophosphate biosynthetic process
is_a: GO:0046033 ! AMP metabolic process
is_a: GO:0046129 ! purine ribonucleoside biosynthetic process

[Term]
id: GO:0006168
name: adenine salvage
namespace: biological_process
def: "Any process that generates adenine, 6-aminopurine, from derivatives of it without de novo synthesis." [GOC:jl]
subset: gosubset_prok
synonym: "adenine salvage pathway" EXACT []
synonym: "adenine, hypoxanthine and their nucleoside salvage" BROAD []
is_a: GO:0043096 ! purine nucleobase salvage
is_a: GO:0046084 ! adenine biosynthetic process

[Term]
id: GO:0006169
name: adenosine salvage
namespace: biological_process
def: "Any process that generates adenosine, adenine riboside, from derivatives of it without de novo synthesis." [GOC:jl]
subset: gosubset_prok
synonym: "adenine, hypoxanthine and their nucleoside salvage" BROAD []
is_a: GO:0006166 ! purine ribonucleoside salvage
is_a: GO:0046086 ! adenosine biosynthetic process

[Term]
id: GO:0006170
name: dAMP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dAMP, deoxyadenosine monophosphate (2'-deoxyadenosine 5'-phosphate)." [ISBN:0198506732]
subset: gosubset_prok
synonym: "dAMP anabolism" EXACT []
synonym: "dAMP biosynthesis" EXACT []
synonym: "dAMP formation" EXACT []
synonym: "dAMP synthesis" EXACT []
is_a: GO:0009153 ! purine deoxyribonucleotide biosynthetic process
is_a: GO:0009171 ! purine deoxyribonucleoside monophosphate biosynthetic process
is_a: GO:0046053 ! dAMP metabolic process

[Term]
id: GO:0006171
name: cAMP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [ISBN:0198506732]
subset: gosubset_prok
synonym: "3',5' cAMP biosynthesis" EXACT []
synonym: "3',5' cAMP biosynthetic process" EXACT []
synonym: "3',5'-cAMP biosynthesis" EXACT []
synonym: "3',5'-cAMP biosynthetic process" EXACT []
synonym: "adenosine 3',5'-cyclophosphate biosynthesis" EXACT []
synonym: "adenosine 3',5'-cyclophosphate biosynthetic process" EXACT []
synonym: "cAMP anabolism" EXACT []
synonym: "cAMP biosynthesis" EXACT []
synonym: "cAMP formation" EXACT []
synonym: "cAMP synthesis" EXACT []
synonym: "cyclic AMP biosynthesis" EXACT []
synonym: "cyclic AMP biosynthetic process" EXACT []
is_a: GO:0009152 ! purine ribonucleotide biosynthetic process
is_a: GO:0046058 ! cAMP metabolic process
is_a: GO:0052652 ! cyclic purine nucleotide metabolic process

[Term]
id: GO:0006172
name: ADP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ADP, adenosine 5'-diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "ADP anabolism" EXACT []
synonym: "ADP biosynthesis" EXACT []
synonym: "ADP formation" EXACT []
synonym: "ADP synthesis" EXACT []
is_a: GO:0009152 ! purine ribonucleotide biosynthetic process
is_a: GO:0009168 ! purine ribonucleoside monophosphate biosynthetic process
is_a: GO:0009180 ! purine ribonucleoside diphosphate biosynthetic process
is_a: GO:0046031 ! ADP metabolic process
is_a: GO:0046129 ! purine ribonucleoside biosynthetic process

[Term]
id: GO:0006173
name: dADP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dADP, deoxyadenosine diphosphate (2'-deoxyadenosine 5'-diphosphate)." [ISBN:0198506732]
subset: gosubset_prok
synonym: "dADP anabolism" EXACT []
synonym: "dADP biosynthesis" EXACT []
synonym: "dADP formation" EXACT []
synonym: "dADP synthesis" EXACT []
is_a: GO:0009153 ! purine deoxyribonucleotide biosynthetic process
is_a: GO:0009183 ! purine deoxyribonucleoside diphosphate biosynthetic process
is_a: GO:0046056 ! dADP metabolic process

[Term]
id: GO:0006174
name: dADP phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group into dADP, deoxyadenosine diphosphate, to produce dATP." [ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0006165 ! nucleoside diphosphate phosphorylation
is_a: GO:0009216 ! purine deoxyribonucleoside triphosphate biosynthetic process
is_a: GO:0046056 ! dADP metabolic process

[Term]
id: GO:0006175
name: dATP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate)." [ISBN:0198506732]
subset: gosubset_prok
synonym: "dATP anabolism" EXACT []
synonym: "dATP biosynthesis" EXACT []
synonym: "dATP formation" EXACT []
synonym: "dATP synthesis" EXACT []
is_a: GO:0009153 ! purine deoxyribonucleotide biosynthetic process
is_a: GO:0009216 ! purine deoxyribonucleoside triphosphate biosynthetic process
is_a: GO:0046060 ! dATP metabolic process

[Term]
id: GO:0006176
name: dATP biosynthetic process from ADP
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate) from other compounds, including ADP, adenosine diphosphate." [ISBN:0198506732]
subset: gosubset_prok
synonym: "dATP anabolism from ADP" EXACT []
synonym: "dATP formation from ADP" EXACT []
synonym: "dATP synthesis from ADP" EXACT []
is_a: GO:0006175 ! dATP biosynthetic process
is_a: GO:0046031 ! ADP metabolic process

[Term]
id: GO:0006177
name: GMP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of GMP, guanosine monophosphate." [ISBN:0198506732]
subset: gosubset_prok
synonym: "GMP anabolism" EXACT []
synonym: "GMP biosynthesis" EXACT []
synonym: "GMP formation" EXACT []
synonym: "GMP synthesis" EXACT []
xref: Reactome:REACT_116076 "De novo synthesis of GMP, Gallus gallus"
is_a: GO:0009152 ! purine ribonucleotide biosynthetic process
is_a: GO:0009168 ! purine ribonucleoside monophosphate biosynthetic process
is_a: GO:0046037 ! GMP metabolic process
is_a: GO:1901070 ! guanosine-containing compound biosynthetic process

[Term]
id: GO:0006178
name: guanine salvage
namespace: biological_process
def: "Any process that generates guanine, 2-amino-6-hydroxypurine, from derivatives of it without de novo synthesis." [GOC:jl]
subset: gosubset_prok
synonym: "guanine, xanthine and their nucleoside salvage" BROAD []
is_a: GO:0043096 ! purine nucleobase salvage
is_a: GO:0046099 ! guanine biosynthetic process

[Term]
id: GO:0006179
name: guanosine salvage
namespace: biological_process
def: "Any process that generates guanosine, guanine riboside, from derivatives of it without de novo synthesis." [GOC:jl]
subset: gosubset_prok
synonym: "guanine, xanthine and their nucleoside salvage" BROAD []
is_a: GO:0006166 ! purine ribonucleoside salvage
is_a: GO:0046114 ! guanosine biosynthetic process

[Term]
id: GO:0006180
name: deoxyguanosine salvage
namespace: biological_process
def: "Any process that generates deoxyguanosine from derivatives of it, without de novo synthesis." [GOC:jl]
subset: gosubset_prok
is_a: GO:0042452 ! deoxyguanosine biosynthetic process
is_a: GO:0043098 ! purine deoxyribonucleoside salvage

[Term]
id: GO:0006181
name: dGMP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dGMP, deoxyguanosine monophosphate (2'-deoxyguanosine 5'-phosphate)." [ISBN:0198506732]
subset: gosubset_prok
synonym: "dGMP anabolism" EXACT []
synonym: "dGMP biosynthesis" EXACT []
synonym: "dGMP formation" EXACT []
synonym: "dGMP synthesis" EXACT []
is_a: GO:0009153 ! purine deoxyribonucleotide biosynthetic process
is_a: GO:0009171 ! purine deoxyribonucleoside monophosphate biosynthetic process
is_a: GO:0046054 ! dGMP metabolic process

[Term]
id: GO:0006182
name: cGMP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate." [ISBN:0198506732]
subset: gosubset_prok
synonym: "cGMP anabolism" EXACT []
synonym: "cGMP biosynthesis" EXACT []
synonym: "cGMP formation" EXACT []
synonym: "cGMP synthesis" EXACT []
is_a: GO:0009152 ! purine ribonucleotide biosynthetic process
is_a: GO:0046068 ! cGMP metabolic process
is_a: GO:0052652 ! cyclic purine nucleotide metabolic process

[Term]
id: GO:0006183
name: GTP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate." [ISBN:0198506732]
subset: gosubset_prok
synonym: "GTP anabolism" EXACT []
synonym: "GTP biosynthesis" EXACT []
synonym: "GTP formation" EXACT []
synonym: "GTP synthesis" EXACT []
is_a: GO:0009152 ! purine ribonucleotide biosynthetic process
is_a: GO:0009206 ! purine ribonucleoside triphosphate biosynthetic process
is_a: GO:0046039 ! GTP metabolic process
is_a: GO:1901070 ! guanosine-containing compound biosynthetic process

[Term]
id: GO:0006184
name: obsolete GTP catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]
comment: The reason for making this term obsolete is that it gets misused in cases where phosphates are simply being removed from a small molecule. We found no cases where these molecules genuinely underwent catabolism.
subset: gosubset_prok
synonym: "GTP breakdown" EXACT []
synonym: "GTP catabolism" EXACT []
synonym: "GTP degradation" EXACT []
synonym: "GTP hydrolysis" NARROW []
is_obsolete: true
consider: GO:0003924

[Term]
id: GO:0006185
name: dGDP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dGDP, deoxyguanosine diphosphate, (2'-deoxyguanosine 5'-diphosphate)." [ISBN:0198506732]
subset: gosubset_prok
synonym: "dGDP anabolism" EXACT []
synonym: "dGDP biosynthesis" EXACT []
synonym: "dGDP formation" EXACT []
synonym: "dGDP synthesis" EXACT []
is_a: GO:0009153 ! purine deoxyribonucleotide biosynthetic process
is_a: GO:0009183 ! purine deoxyribonucleoside diphosphate biosynthetic process
is_a: GO:0046066 ! dGDP metabolic process

[Term]
id: GO:0006186
name: dGDP phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group into dGDP, deoxyguanosine diphosphate, to produce dGTP." [ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0006165 ! nucleoside diphosphate phosphorylation
is_a: GO:0009216 ! purine deoxyribonucleoside triphosphate biosynthetic process
is_a: GO:0046066 ! dGDP metabolic process

[Term]
id: GO:0006187
name: dGTP biosynthetic process from dGDP
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dGTP, deoxyguanosine triphosphate (2'-deoxyguanosine 5'-triphosphate) from other compounds, including gGDP, deoxyguanosine diphosphate." [ISBN:0198506732]
subset: gosubset_prok
synonym: "dGTP anabolism from dGDP" EXACT []
synonym: "dGTP formation from dGDP" EXACT []
synonym: "dGTP synthesis from dGDP" EXACT []
is_a: GO:0046066 ! dGDP metabolic process
is_a: GO:0046071 ! dGTP biosynthetic process

[Term]
id: GO:0006188
name: IMP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate." [ISBN:0198506732]
subset: gosubset_prok
synonym: "IMP anabolism" EXACT []
synonym: "IMP biosynthesis" EXACT []
synonym: "IMP formation" EXACT []
synonym: "IMP synthesis" EXACT []
is_a: GO:0009152 ! purine ribonucleotide biosynthetic process
is_a: GO:0009168 ! purine ribonucleoside monophosphate biosynthetic process
is_a: GO:0046040 ! IMP metabolic process

[Term]
id: GO:0006189
name: 'de novo' IMP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate." [GOC:mah, ISBN:0716720094]
subset: gosubset_prok
synonym: "'de novo' IMP anabolism" EXACT []
synonym: "'de novo' IMP biosynthesis" EXACT []
synonym: "'de novo' IMP formation" EXACT []
synonym: "'de novo' IMP synthesis" EXACT []
synonym: "'de novo' purine biosynthesis" BROAD []
synonym: "'de novo' purine biosynthetic process" BROAD []
xref: Reactome:REACT_116007 "De novo synthesis of IMP, Gallus gallus"
is_a: GO:0006188 ! IMP biosynthetic process

[Term]
id: GO:0006190
name: inosine salvage
namespace: biological_process
def: "Any process that generates inosine, hypoxanthine riboside, from derivatives of it without de novo synthesis." [GOC:jl]
subset: gosubset_prok
synonym: "adenine, hypoxanthine and their nucleoside salvage" RELATED []
synonym: "guanine, xanthine and their nucleoside salvage" RELATED []
is_a: GO:0006166 ! purine ribonucleoside salvage
is_a: GO:0046103 ! inosine biosynthetic process

[Term]
id: GO:0006191
name: deoxyinosine salvage
namespace: biological_process
def: "Any process that generates deoxyinosine from derivatives of it, without de novo synthesis." [GOC:jl]
subset: gosubset_prok
is_a: GO:0043098 ! purine deoxyribonucleoside salvage
is_a: GO:0046095 ! deoxyinosine biosynthetic process

[Term]
id: GO:0006192
name: IDP phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group into IDP, inosine (5'-)diphosphate, to produce ITP." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006165 ! nucleoside diphosphate phosphorylation
is_a: GO:0009206 ! purine ribonucleoside triphosphate biosynthetic process
is_a: GO:0046707 ! IDP metabolic process

[Term]
id: GO:0006193
name: ITP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ITP, inosine (5'-)triphosphate." [ISBN:0198506732]
subset: gosubset_prok
synonym: "ITP breakdown" EXACT []
synonym: "ITP catabolism" EXACT []
synonym: "ITP degradation" EXACT []
synonym: "ITP hydrolysis" EXACT []
is_a: GO:0009154 ! purine ribonucleotide catabolic process
is_a: GO:0009207 ! purine ribonucleoside triphosphate catabolic process
is_a: GO:0046041 ! ITP metabolic process

[Term]
id: GO:0006194
name: dIDP phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group into dIDP, deoxyinosine diphosphate, to produce dITP." [ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0006165 ! nucleoside diphosphate phosphorylation
is_a: GO:0009216 ! purine deoxyribonucleoside triphosphate biosynthetic process

[Term]
id: GO:0006195
name: purine nucleotide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "purine nucleotide breakdown" EXACT []
synonym: "purine nucleotide catabolism" EXACT []
synonym: "purine nucleotide degradation" EXACT []
xref: Reactome:REACT_100331 "Purine catabolism, Dictyostelium discoideum"
xref: Reactome:REACT_104277 "Purine catabolism, Xenopus tropicalis"
xref: Reactome:REACT_105169 "Purine catabolism, Schizosaccharomyces pombe"
xref: Reactome:REACT_105236 "Purine catabolism, Staphylococcus aureus N315"
xref: Reactome:REACT_107505 "Purine catabolism, Oryza sativa"
xref: Reactome:REACT_113844 "Purine catabolism, Plasmodium falciparum"
xref: Reactome:REACT_2086 "Purine catabolism, Homo sapiens"
xref: Reactome:REACT_30574 "Purine catabolism, Saccharomyces cerevisiae"
xref: Reactome:REACT_31958 "Purine catabolism, Drosophila melanogaster"
xref: Reactome:REACT_33664 "Purine catabolism, Mus musculus"
xref: Reactome:REACT_34219 "Purine catabolism, Taeniopygia guttata"
xref: Reactome:REACT_58357 "Purine catabolism, Canis familiaris"
xref: Reactome:REACT_77442 "Purine catabolism, Danio rerio"
xref: Reactome:REACT_77815 "Purine catabolism, Gallus gallus"
xref: Reactome:REACT_78778 "Purine catabolism, Caenorhabditis elegans"
xref: Reactome:REACT_85047 "Purine catabolism, Mycobacterium tuberculosis"
xref: Reactome:REACT_91836 "Purine catabolism, Rattus norvegicus"
xref: Reactome:REACT_95337 "Purine catabolism, Sus scrofa"
xref: Reactome:REACT_95719 "Purine catabolism, Escherichia coli"
xref: Reactome:REACT_98589 "Purine catabolism, Bos taurus"
xref: Reactome:REACT_99571 "Purine catabolism, Arabidopsis thaliana"
is_a: GO:0006163 ! purine nucleotide metabolic process
is_a: GO:0009166 ! nucleotide catabolic process
is_a: GO:0072523 ! purine-containing compound catabolic process

[Term]
id: GO:0006196
name: AMP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of AMP, adenosine monophosphate." [ISBN:0198506732]
subset: gosubset_prok
synonym: "AMP breakdown" EXACT []
synonym: "AMP catabolism" EXACT []
synonym: "AMP degradation" EXACT []
is_a: GO:0009154 ! purine ribonucleotide catabolic process
is_a: GO:0009169 ! purine ribonucleoside monophosphate catabolic process
is_a: GO:0046033 ! AMP metabolic process
is_a: GO:0046130 ! purine ribonucleoside catabolic process

[Term]
id: GO:0006197
name: obsolete adenylate deaminase reaction
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function.
synonym: "adenylate deaminase reaction" EXACT []
is_obsolete: true
replaced_by: GO:0003876

[Term]
id: GO:0006198
name: cAMP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [ISBN:0198506732]
subset: gosubset_prok
synonym: "3',5' cAMP catabolic process" EXACT []
synonym: "3',5' cAMP catabolism" EXACT []
synonym: "3',5'-cAMP catabolic process" EXACT []
synonym: "3',5'-cAMP catabolism" EXACT []
synonym: "adenosine 3',5'-cyclophosphate catabolic process" EXACT []
synonym: "adenosine 3',5'-cyclophosphate catabolism" EXACT []
synonym: "cAMP breakdown" EXACT []
synonym: "cAMP catabolism" EXACT []
synonym: "cAMP degradation" EXACT []
synonym: "cyclic AMP catabolic process" EXACT []
synonym: "cyclic AMP catabolism" EXACT []
is_a: GO:0009154 ! purine ribonucleotide catabolic process
is_a: GO:0009214 ! cyclic nucleotide catabolic process
is_a: GO:0046058 ! cAMP metabolic process

[Term]
id: GO:0006199
name: obsolete ADP reduction
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function rather than a biological process.
synonym: "ADP reduction" EXACT []
is_obsolete: true
consider: GO:0051061

[Term]
id: GO:0006200
name: obsolete ATP catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
comment: The reason for making this term obsolete is that it gets misused in cases where phosphates are simply being removed from a small molecule. We found no cases where these molecules genuinely underwent catabolism.
subset: gosubset_prok
synonym: "ATP breakdown" EXACT []
synonym: "ATP catabolism" EXACT []
synonym: "ATP degradation" EXACT []
synonym: "ATP hydrolysis" NARROW []
xref: Wikipedia:ATP_hydrolysis
is_obsolete: true
consider: GO:0016887

[Term]
id: GO:0006201
name: GMP catabolic process to IMP
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of guanosine monophosphate into other compounds, including inosine monophosphate." [ISBN:0198506732]
subset: gosubset_prok
synonym: "GMP breakdown to IMP" EXACT []
synonym: "GMP degradation to IMP" EXACT []
is_a: GO:0046038 ! GMP catabolic process
is_a: GO:0046040 ! IMP metabolic process

[Term]
id: GO:0006202
name: GMP catabolic process to guanine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of guanosine monophosphate into other compounds, including guanine." [ISBN:0198506732]
subset: gosubset_prok
synonym: "GMP breakdown to guanine" EXACT []
synonym: "GMP degradation to guanine" EXACT []
is_a: GO:0046038 ! GMP catabolic process
is_a: GO:0046098 ! guanine metabolic process

[Term]
id: GO:0006203
name: dGTP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dGTP, guanosine triphosphate." [ISBN:0198506732]
subset: gosubset_prok
synonym: "dGTP breakdown" EXACT []
synonym: "dGTP catabolism" EXACT []
synonym: "dGTP degradation" EXACT []
is_a: GO:0009155 ! purine deoxyribonucleotide catabolic process
is_a: GO:0009217 ! purine deoxyribonucleoside triphosphate catabolic process
is_a: GO:0046070 ! dGTP metabolic process

[Term]
id: GO:0006204
name: IMP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of IMP, inosine monophosphate." [ISBN:0198506732]
subset: gosubset_prok
synonym: "IMP breakdown" EXACT []
synonym: "IMP catabolism" EXACT []
synonym: "IMP degradation" EXACT []
is_a: GO:0009154 ! purine ribonucleotide catabolic process
is_a: GO:0009169 ! purine ribonucleoside monophosphate catabolic process
is_a: GO:0046040 ! IMP metabolic process

[Term]
id: GO:0006205
name: obsolete pyrimidine metabolic process
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because more appropriate terms were created.
synonym: "pyrimidine metabolic process" EXACT []
is_obsolete: true
consider: GO:0006206
consider: GO:0006213
consider: GO:0006220

[Term]
id: GO:0006206
name: pyrimidine nucleobase metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases." [CHEBI:26432, GOC:go_curators]
subset: gosubset_prok
synonym: "pyrimidine base metabolic process" EXACT [GOC:go_curators]
synonym: "pyrimidine base metabolism" EXACT []
synonym: "pyrimidine metabolic process" RELATED []
synonym: "pyrimidine metabolism" RELATED []
xref: Reactome:REACT_108222 "Pyrimidine metabolism, Xenopus tropicalis"
xref: Reactome:REACT_116126 "Pyrimidine metabolism, Gallus gallus"
xref: Reactome:REACT_29344 "Pyrimidine metabolism, Escherichia coli"
xref: Reactome:REACT_30021 "Pyrimidine metabolism, Oryza sativa"
xref: Reactome:REACT_30436 "Pyrimidine metabolism, Schizosaccharomyces pombe"
xref: Reactome:REACT_30595 "Pyrimidine metabolism, Mus musculus"
xref: Reactome:REACT_32174 "Pyrimidine metabolism, Mycobacterium tuberculosis"
xref: Reactome:REACT_32589 "Pyrimidine metabolism, Saccharomyces cerevisiae"
xref: Reactome:REACT_33296 "Pyrimidine metabolism, Sus scrofa"
xref: Reactome:REACT_82313 "Pyrimidine metabolism, Rattus norvegicus"
xref: Reactome:REACT_83435 "Pyrimidine metabolism, Taeniopygia guttata"
xref: Reactome:REACT_84466 "Pyrimidine metabolism, Plasmodium falciparum"
xref: Reactome:REACT_84997 "Pyrimidine metabolism, Bos taurus"
xref: Reactome:REACT_85132 "Pyrimidine metabolism, Danio rerio"
xref: Reactome:REACT_86085 "Pyrimidine metabolism, Arabidopsis thaliana"
xref: Reactome:REACT_86228 "Pyrimidine metabolism, Canis familiaris"
xref: Reactome:REACT_87817 "Pyrimidine metabolism, Caenorhabditis elegans"
xref: Reactome:REACT_90567 "Pyrimidine metabolism, Drosophila melanogaster"
xref: Reactome:REACT_93216 "Pyrimidine metabolism, Dictyostelium discoideum"
xref: Reactome:REACT_94169 "Pyrimidine metabolism, Gallus gallus"
xref: Reactome:REACT_957 "Pyrimidine metabolism, Homo sapiens"
xref: Reactome:REACT_98410 "Pyrimidine metabolism, Staphylococcus aureus N315"
is_a: GO:0009112 ! nucleobase metabolic process
is_a: GO:0072527 ! pyrimidine-containing compound metabolic process

[Term]
id: GO:0006207
name: 'de novo' pyrimidine nucleobase biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors." [GOC:mah, ISBN:0716720094]
subset: gosubset_prok
synonym: "'de novo' pyrimidine base anabolism" EXACT []
synonym: "'de novo' pyrimidine base biosynthesis" EXACT []
synonym: "'de novo' pyrimidine base biosynthetic process" EXACT [GOC:go_curators]
synonym: "'de novo' pyrimidine base formation" EXACT []
synonym: "'de novo' pyrimidine base synthesis" EXACT []
is_a: GO:0019856 ! pyrimidine nucleobase biosynthetic process

[Term]
id: GO:0006208
name: pyrimidine nucleobase catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases." [CHEBI:26432, GOC:go_curators]
subset: gosubset_prok
synonym: "pyrimidine base breakdown" EXACT []
synonym: "pyrimidine base catabolic process" EXACT [GOC:go_curators]
synonym: "pyrimidine base catabolism" EXACT []
synonym: "pyrimidine base degradation" EXACT []
is_a: GO:0006206 ! pyrimidine nucleobase metabolic process
is_a: GO:0046113 ! nucleobase catabolic process
is_a: GO:0072529 ! pyrimidine-containing compound catabolic process

[Term]
id: GO:0006209
name: cytosine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cytosine, 4-amino-2-hydroxypyrimidine, a pyrimidine derivative that is one of the five main bases found in nucleic acids; it occurs widely in cytidine derivatives." [GOC:go_curators]
subset: gosubset_prok
synonym: "cytosine breakdown" EXACT []
synonym: "cytosine catabolism" EXACT []
synonym: "cytosine degradation" EXACT []
is_a: GO:0006208 ! pyrimidine nucleobase catabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0019858 ! cytosine metabolic process

[Term]
id: GO:0006210
name: thymine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base." [GOC:go_curators]
subset: gosubset_prok
synonym: "thymine breakdown" EXACT []
synonym: "thymine catabolism" EXACT []
synonym: "thymine degradation" EXACT []
is_a: GO:0006208 ! pyrimidine nucleobase catabolic process
is_a: GO:0019859 ! thymine metabolic process

[Term]
id: GO:0006211
name: 5-methylcytosine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 5-methylcytosine, a methylated base of DNA." [GOC:go_curators]
subset: gosubset_prok
synonym: "5-methylcytosine breakdown" EXACT []
synonym: "5-methylcytosine catabolism" EXACT []
synonym: "5-methylcytosine degradation" EXACT []
is_a: GO:0019857 ! 5-methylcytosine metabolic process
is_a: GO:0072529 ! pyrimidine-containing compound catabolic process

[Term]
id: GO:0006212
name: uracil catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA." [GOC:go_curators]
subset: gosubset_prok
synonym: "uracil breakdown" EXACT []
synonym: "uracil catabolism" EXACT []
synonym: "uracil degradation" EXACT []
is_a: GO:0006208 ! pyrimidine nucleobase catabolic process
is_a: GO:0019860 ! uracil metabolic process

[Term]
id: GO:0006213
name: pyrimidine nucleoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:jl, ISBN:0140512713]
subset: gosubset_prok
synonym: "pyrimidine metabolic process" BROAD []
synonym: "pyrimidine metabolism" BROAD []
synonym: "pyrimidine nucleoside metabolism" EXACT []
is_a: GO:0009116 ! nucleoside metabolic process
is_a: GO:0072527 ! pyrimidine-containing compound metabolic process

[Term]
id: GO:0006214
name: thymidine catabolic process
namespace: biological_process
alt_id: GO:0006215
def: "The chemical reactions and pathways resulting in the breakdown of thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA." [GOC:go_curators]
subset: gosubset_prok
synonym: "deoxyribosylthymine catabolic process" EXACT []
synonym: "deoxyribosylthymine catabolism" EXACT []
synonym: "thymidine breakdown" EXACT []
synonym: "thymidine catabolism" EXACT []
synonym: "thymidine degradation" EXACT []
is_a: GO:0046104 ! thymidine metabolic process
is_a: GO:0046127 ! pyrimidine deoxyribonucleoside catabolic process

[Term]
id: GO:0006216
name: cytidine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cytidine, cytosine riboside, a widely distributed nucleoside." [GOC:ai]
subset: gosubset_prok
synonym: "cytidine breakdown" EXACT []
synonym: "cytidine catabolism" EXACT []
synonym: "cytidine degradation" EXACT []
is_a: GO:0046087 ! cytidine metabolic process
is_a: GO:0046133 ! pyrimidine ribonucleoside catabolic process

[Term]
id: GO:0006217
name: deoxycytidine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of deoxycytidine, 2-deoxyribosylcytosine, one of the four major nucleosides of DNA." [GOC:go_curators]
subset: gosubset_prok
synonym: "deoxycytidine breakdown" EXACT []
synonym: "deoxycytidine catabolism" EXACT []
synonym: "deoxycytidine degradation" EXACT []
is_a: GO:0046092 ! deoxycytidine metabolic process
is_a: GO:0046127 ! pyrimidine deoxyribonucleoside catabolic process

[Term]
id: GO:0006218
name: uridine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids." [GOC:go_curators]
subset: gosubset_prok
synonym: "uridine breakdown" EXACT []
synonym: "uridine catabolism" EXACT []
synonym: "uridine degradation" EXACT []
is_a: GO:0046108 ! uridine metabolic process
is_a: GO:0046133 ! pyrimidine ribonucleoside catabolic process

[Term]
id: GO:0006219
name: deoxyuridine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of deoxyuridine, 2-deoxyribosyluracil, one of the four major nucleosides of DNA." [GOC:go_curators]
subset: gosubset_prok
synonym: "deoxyuridine breakdown" EXACT []
synonym: "deoxyuridine catabolism" EXACT []
synonym: "deoxyuridine degradation" EXACT []
is_a: GO:0046096 ! deoxyuridine metabolic process
is_a: GO:0046127 ! pyrimidine deoxyribonucleoside catabolic process

[Term]
id: GO:0006220
name: pyrimidine nucleotide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "pyrimidine metabolic process" BROAD []
synonym: "pyrimidine metabolism" BROAD []
synonym: "pyrimidine nucleotide metabolism" EXACT []
is_a: GO:0009117 ! nucleotide metabolic process
is_a: GO:0072527 ! pyrimidine-containing compound metabolic process

[Term]
id: GO:0006221
name: pyrimidine nucleotide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "pyrimidine nucleotide anabolism" EXACT []
synonym: "pyrimidine nucleotide biosynthesis" EXACT []
synonym: "pyrimidine nucleotide formation" EXACT []
synonym: "pyrimidine nucleotide synthesis" EXACT []
is_a: GO:0006220 ! pyrimidine nucleotide metabolic process
is_a: GO:0009165 ! nucleotide biosynthetic process
is_a: GO:0072528 ! pyrimidine-containing compound biosynthetic process

[Term]
id: GO:0006222
name: UMP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate." [ISBN:0198506732]
subset: gosubset_prok
synonym: "UMP anabolism" EXACT []
synonym: "UMP biosynthesis" EXACT []
synonym: "UMP formation" EXACT []
synonym: "UMP synthesis" EXACT []
xref: Reactome:REACT_116021 "De novo synthesis of UMP, Gallus gallus"
is_a: GO:0009174 ! pyrimidine ribonucleoside monophosphate biosynthetic process
is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process
is_a: GO:0046049 ! UMP metabolic process
is_a: GO:0046132 ! pyrimidine ribonucleoside biosynthetic process

[Term]
id: GO:0006223
name: uracil salvage
namespace: biological_process
def: "Any process that generates uracil, 2,4-dioxopyrimidine, from derivatives of it without de novo synthesis." [GOC:jl]
subset: gosubset_prok
is_a: GO:0043100 ! pyrimidine nucleobase salvage
is_a: GO:0046107 ! uracil biosynthetic process

[Term]
id: GO:0006224
name: obsolete uridine kinase reaction
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function.
synonym: "uridine kinase reaction" EXACT []
is_obsolete: true
replaced_by: GO:0004849

[Term]
id: GO:0006225
name: UDP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of UDP, uridine (5'-)diphosphate." [ISBN:0198506732]
subset: gosubset_prok
synonym: "UDP anabolism" EXACT []
synonym: "UDP biosynthesis" EXACT []
synonym: "UDP formation" EXACT []
synonym: "UDP synthesis" EXACT []
is_a: GO:0009194 ! pyrimidine ribonucleoside diphosphate biosynthetic process
is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process
is_a: GO:0046048 ! UDP metabolic process
is_a: GO:0046132 ! pyrimidine ribonucleoside biosynthetic process

[Term]
id: GO:0006226
name: dUMP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dUMP, deoxyuridine monophosphate (2'-deoxyuridine 5'-phosphate)." [ISBN:0198506732]
subset: gosubset_prok
synonym: "dUMP anabolism" EXACT []
synonym: "dUMP biosynthesis" EXACT []
synonym: "dUMP formation" EXACT []
synonym: "dUMP synthesis" EXACT []
is_a: GO:0009177 ! pyrimidine deoxyribonucleoside monophosphate biosynthetic process
is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process
is_a: GO:0046078 ! dUMP metabolic process

[Term]
id: GO:0006227
name: dUDP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dUDP, deoxyuridine diphosphate (2'-deoxy-5'-uridylyl phosphate)." [ISBN:0198506732]
subset: gosubset_prok
synonym: "dUDP anabolism" EXACT []
synonym: "dUDP biosynthesis" EXACT []
synonym: "dUDP formation" EXACT []
synonym: "dUDP synthesis" EXACT []
is_a: GO:0009197 ! pyrimidine deoxyribonucleoside diphosphate biosynthetic process
is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process
is_a: GO:0046077 ! dUDP metabolic process

[Term]
id: GO:0006228
name: UTP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate." [ISBN:0198506732]
subset: gosubset_prok
synonym: "UTP anabolism" EXACT []
synonym: "UTP biosynthesis" EXACT []
synonym: "UTP formation" EXACT []
synonym: "UTP synthesis" EXACT []
is_a: GO:0009209 ! pyrimidine ribonucleoside triphosphate biosynthetic process
is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process
is_a: GO:0046051 ! UTP metabolic process
is_a: GO:0046132 ! pyrimidine ribonucleoside biosynthetic process

[Term]
id: GO:0006229
name: dUTP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dUTP, deoxyuridine (5'-)triphosphate." [ISBN:0198506732]
subset: gosubset_prok
synonym: "dUTP anabolism" EXACT []
synonym: "dUTP biosynthesis" EXACT []
synonym: "dUTP formation" EXACT []
synonym: "dUTP synthesis" EXACT []
is_a: GO:0009212 ! pyrimidine deoxyribonucleoside triphosphate biosynthetic process
is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process
is_a: GO:0046080 ! dUTP metabolic process

[Term]
id: GO:0006230
name: TMP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of TMP, ribosylthymine monophosphate." [ISBN:0198506732]
subset: gosubset_prok
synonym: "TMP anabolism" EXACT []
synonym: "TMP biosynthesis" EXACT []
synonym: "TMP formation" EXACT []
synonym: "TMP synthesis" EXACT []
is_a: GO:0009174 ! pyrimidine ribonucleoside monophosphate biosynthetic process
is_a: GO:0009177 ! pyrimidine deoxyribonucleoside monophosphate biosynthetic process
is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process
is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process
is_a: GO:0046044 ! TMP metabolic process

[Term]
id: GO:0006231
name: dTMP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate)." [ISBN:0198506732]
subset: gosubset_prok
synonym: "dTMP anabolism" EXACT []
synonym: "dTMP biosynthesis" EXACT []
synonym: "dTMP formation" EXACT []
synonym: "dTMP synthesis" EXACT []
is_a: GO:0009177 ! pyrimidine deoxyribonucleoside monophosphate biosynthetic process
is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process
is_a: GO:0046073 ! dTMP metabolic process

[Term]
id: GO:0006232
name: TDP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of TDP, ribosylthymine diphosphate." [ISBN:0198506732]
subset: gosubset_prok
synonym: "TDP anabolism" EXACT []
synonym: "TDP biosynthesis" EXACT []
synonym: "TDP formation" EXACT []
synonym: "TDP synthesis" EXACT []
is_a: GO:0009194 ! pyrimidine ribonucleoside diphosphate biosynthetic process
is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process
is_a: GO:0046043 ! TDP metabolic process

[Term]
id: GO:0006233
name: dTDP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dTDP, deoxyribosylthymine diphosphate (2'-deoxyribosylthymine5'-diphosphate)." [ISBN:0198506732]
subset: gosubset_prok
synonym: "dTDP anabolism" EXACT []
synonym: "dTDP biosynthesis" EXACT []
synonym: "dTDP formation" EXACT []
synonym: "dTDP synthesis" EXACT []
is_a: GO:0009197 ! pyrimidine deoxyribonucleoside diphosphate biosynthetic process
is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process
is_a: GO:0046072 ! dTDP metabolic process

[Term]
id: GO:0006234
name: TTP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of TTP, ribosylthymine triphosphate." [ISBN:0198506732]
subset: gosubset_prok
synonym: "TTP anabolism" EXACT []
synonym: "TTP biosynthesis" EXACT []
synonym: "TTP formation" EXACT []
synonym: "TTP synthesis" EXACT []
is_a: GO:0009209 ! pyrimidine ribonucleoside triphosphate biosynthetic process
is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process
is_a: GO:0046046 ! TTP metabolic process

[Term]
id: GO:0006235
name: dTTP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dTTP, deoxyribosylthymine triphosphate." [ISBN:0198506732]
subset: gosubset_prok
synonym: "dTTP anabolism" EXACT []
synonym: "dTTP biosynthesis" EXACT []
synonym: "dTTP formation" EXACT []
synonym: "dTTP synthesis" EXACT []
is_a: GO:0009212 ! pyrimidine deoxyribonucleoside triphosphate biosynthetic process
is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process
is_a: GO:0046075 ! dTTP metabolic process

[Term]
id: GO:0006236
name: cytidine salvage
namespace: biological_process
def: "Any process that generates cytidine, cytosine riboside, from derivatives of it without de novo synthesis." [GOC:jl]
subset: gosubset_prok
is_a: GO:0043097 ! pyrimidine nucleoside salvage
is_a: GO:0046088 ! cytidine biosynthetic process

[Term]
id: GO:0006237
name: deoxycytidine salvage
namespace: biological_process
def: "Any process that generates deoxycytidine, 2-deoxyribosylcytosine, from derivatives of it, without de novo synthesis." [GOC:jl]
subset: gosubset_prok
is_a: GO:0043099 ! pyrimidine deoxyribonucleoside salvage
is_a: GO:0046093 ! deoxycytidine biosynthetic process

[Term]
id: GO:0006238
name: CMP salvage
namespace: biological_process
def: "Any process that generates CMP, cytidine monophosphate, from derivatives of it without de novo synthesis." [GOC:jl]
subset: gosubset_prok
synonym: "cytidine monophosphate salvage" EXACT []
is_a: GO:0009224 ! CMP biosynthetic process
is_a: GO:0010138 ! pyrimidine ribonucleotide salvage
is_a: GO:0043097 ! pyrimidine nucleoside salvage

[Term]
id: GO:0006239
name: dCMP salvage
namespace: biological_process
def: "Any process that generates dCMP, deoxycytidine monophosphate from derivatives of it, without de novo synthesis." [GOC:jl]
subset: gosubset_prok
synonym: "deoxycytidine monophosphate salvage" EXACT []
is_a: GO:0010139 ! pyrimidine deoxyribonucleotide salvage
is_a: GO:0046064 ! dCMP biosynthetic process

[Term]
id: GO:0006240
name: dCDP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dCDP, deoxycytidine 5'-diphosphate." [ISBN:0198506732]
subset: gosubset_prok
synonym: "dCDP anabolism" EXACT []
synonym: "dCDP biosynthesis" EXACT []
synonym: "dCDP formation" EXACT []
synonym: "dCDP synthesis" EXACT []
is_a: GO:0009197 ! pyrimidine deoxyribonucleoside diphosphate biosynthetic process
is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process
is_a: GO:0046062 ! dCDP metabolic process

[Term]
id: GO:0006241
name: CTP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate." [ISBN:0198506732]
subset: gosubset_prok
synonym: "CTP anabolism" EXACT []
synonym: "CTP biosynthesis" EXACT []
synonym: "CTP formation" EXACT []
synonym: "CTP synthesis" EXACT []
is_a: GO:0009209 ! pyrimidine ribonucleoside triphosphate biosynthetic process
is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process
is_a: GO:0046036 ! CTP metabolic process
is_a: GO:0046132 ! pyrimidine ribonucleoside biosynthetic process

[Term]
id: GO:0006242
name: dCTP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dCTP, deoxycytidine triphosphate." [ISBN:0198506732]
subset: gosubset_prok
synonym: "dCTP anabolism" EXACT []
synonym: "dCTP biosynthesis" EXACT []
synonym: "dCTP formation" EXACT []
synonym: "dCTP synthesis" EXACT []
is_a: GO:0009212 ! pyrimidine deoxyribonucleoside triphosphate biosynthetic process
is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process
is_a: GO:0046065 ! dCTP metabolic process

[Term]
id: GO:0006244
name: pyrimidine nucleotide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "pyrimidine nucleotide breakdown" EXACT []
synonym: "pyrimidine nucleotide catabolism" EXACT []
synonym: "pyrimidine nucleotide degradation" EXACT []
is_a: GO:0006220 ! pyrimidine nucleotide metabolic process
is_a: GO:0009166 ! nucleotide catabolic process
is_a: GO:0072529 ! pyrimidine-containing compound catabolic process

[Term]
id: GO:0006245
name: TDP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of TDP, ribosylthymine diphosphate." [ISBN:0198506732]
subset: gosubset_prok
synonym: "TDP breakdown" EXACT []
synonym: "TDP catabolism" EXACT []
synonym: "TDP degradation" EXACT []
is_a: GO:0009195 ! pyrimidine ribonucleoside diphosphate catabolic process
is_a: GO:0009222 ! pyrimidine ribonucleotide catabolic process
is_a: GO:0046043 ! TDP metabolic process

[Term]
id: GO:0006246
name: dTDP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dTDP, deoxyribosylthymine diphosphate." [ISBN:0198506732]
subset: gosubset_prok
synonym: "dTDP breakdown" EXACT []
synonym: "dTDP catabolism" EXACT []
synonym: "dTDP degradation" EXACT []
is_a: GO:0009198 ! pyrimidine deoxyribonucleoside diphosphate catabolic process
is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process
is_a: GO:0046072 ! dTDP metabolic process

[Term]
id: GO:0006247
name: obsolete TTP reduction
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function rather than a biological process.
synonym: "TTP reduction" EXACT []
is_obsolete: true
consider: GO:0051064

[Term]
id: GO:0006248
name: CMP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of CMP, cytidine monophosphate." [ISBN:0198506732]
subset: gosubset_prok
synonym: "CMP breakdown" EXACT []
synonym: "CMP catabolism" EXACT []
synonym: "CMP degradation" EXACT []
is_a: GO:0009175 ! pyrimidine ribonucleoside monophosphate catabolic process
is_a: GO:0009222 ! pyrimidine ribonucleotide catabolic process
is_a: GO:0046035 ! CMP metabolic process
is_a: GO:0046133 ! pyrimidine ribonucleoside catabolic process

[Term]
id: GO:0006249
name: dCMP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dCMP, deoxycytidine monophosphate." [ISBN:0198506732]
subset: gosubset_prok
synonym: "dCMP breakdown" EXACT []
synonym: "dCMP catabolism" EXACT []
synonym: "dCMP degradation" EXACT []
is_a: GO:0009178 ! pyrimidine deoxyribonucleoside monophosphate catabolic process
is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process
is_a: GO:0046063 ! dCMP metabolic process

[Term]
id: GO:0006250
name: obsolete CDP reduction
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function rather than a biological process.
synonym: "CDP reduction" EXACT []
is_obsolete: true
consider: GO:0051063

[Term]
id: GO:0006251
name: dCDP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dCDP, deoxycytidine 5'-diphosphate." [ISBN:0198506732]
subset: gosubset_prok
synonym: "dCDP breakdown" EXACT []
synonym: "dCDP catabolism" EXACT []
synonym: "dCDP degradation" EXACT []
is_a: GO:0009198 ! pyrimidine deoxyribonucleoside diphosphate catabolic process
is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process
is_a: GO:0046062 ! dCDP metabolic process

[Term]
id: GO:0006252
name: obsolete CTP reduction
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function rather than a biological process.
synonym: "CTP reduction" EXACT []
is_obsolete: true
consider: GO:0051065

[Term]
id: GO:0006253
name: dCTP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dCTP, deoxycytidine triphosphate." [ISBN:0198506732]
subset: gosubset_prok
synonym: "dCTP breakdown" EXACT []
synonym: "dCTP catabolism" EXACT []
synonym: "dCTP degradation" EXACT []
is_a: GO:0009213 ! pyrimidine deoxyribonucleoside triphosphate catabolic process
is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process
is_a: GO:0046065 ! dCTP metabolic process

[Term]
id: GO:0006254
name: CTP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of CTP, cytidine 5'-triphosphate." [ISBN:0198506732]
subset: gosubset_prok
synonym: "CTP breakdown" EXACT []
synonym: "CTP catabolism" EXACT []
synonym: "CTP degradation" EXACT []
synonym: "CTP hydrolysis" EXACT []
is_a: GO:0009210 ! pyrimidine ribonucleoside triphosphate catabolic process
is_a: GO:0009222 ! pyrimidine ribonucleotide catabolic process
is_a: GO:0046036 ! CTP metabolic process
is_a: GO:0046133 ! pyrimidine ribonucleoside catabolic process

[Term]
id: GO:0006255
name: obsolete UDP reduction
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function rather than a biological process.
synonym: "UDP reduction" EXACT []
is_obsolete: true
consider: GO:0051062

[Term]
id: GO:0006256
name: UDP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of UDP, uridine (5'-)diphosphate." [ISBN:0198506732]
subset: gosubset_prok
synonym: "UDP breakdown" EXACT []
synonym: "UDP catabolism" EXACT []
synonym: "UDP degradation" EXACT []
is_a: GO:0009195 ! pyrimidine ribonucleoside diphosphate catabolic process
is_a: GO:0009222 ! pyrimidine ribonucleotide catabolic process
is_a: GO:0046048 ! UDP metabolic process
is_a: GO:0046133 ! pyrimidine ribonucleoside catabolic process

[Term]
id: GO:0006257
name: dUDP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dUDP, deoxyuridine (5'-)diphosphate." [ISBN:0198506732]
subset: gosubset_prok
synonym: "dUDP breakdown" EXACT []
synonym: "dUDP catabolism" EXACT []
synonym: "dUDP degradation" EXACT []
is_a: GO:0009198 ! pyrimidine deoxyribonucleoside diphosphate catabolic process
is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process
is_a: GO:0046077 ! dUDP metabolic process

[Term]
id: GO:0006258
name: UDP-glucose catabolic process
namespace: biological_process
alt_id: GO:0019691
def: "The chemical reactions and pathways resulting in the breakdown of UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "UDP-glucose breakdown" EXACT []
synonym: "UDP-glucose catabolism" EXACT []
synonym: "UDP-glucose conversion" RELATED []
synonym: "UDP-glucose degradation" EXACT []
is_a: GO:0006011 ! UDP-glucose metabolic process
is_a: GO:0009227 ! nucleotide-sugar catabolic process

[Term]
id: GO:0006259
name: DNA metabolic process
namespace: biological_process
alt_id: GO:0055132
def: "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "cellular DNA metabolism" EXACT []
synonym: "DNA metabolism" EXACT []
is_a: GO:0044260 ! cellular macromolecule metabolic process
is_a: GO:0090304 ! nucleic acid metabolic process

[Term]
id: GO:0006260
name: DNA replication
namespace: biological_process
alt_id: GO:0055133
def: "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]
comment: DNA biosynthesis is only part of this process. See also the biological process terms 'DNA-dependent DNA replication ; GO:0006261' and 'RNA-dependent DNA replication ; GO:0006278'.
subset: goslim_pir
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
xref: Reactome:REACT_100559 "Activation of ATR in response to replication stress, Mus musculus"
xref: Reactome:REACT_101280 "Activation of claspin, Xenopus tropicalis"
xref: Reactome:REACT_101497 "Activation of claspin, Bos taurus"
xref: Reactome:REACT_102679 "Activation of ATR in response to replication stress, Gallus gallus"
xref: Reactome:REACT_103614 "Stalling of DNA replication fork and RPA binding, Taeniopygia guttata"
xref: Reactome:REACT_104547 "Recruitment and activation of Chk1, Gallus gallus"
xref: Reactome:REACT_105292 "Activation of ATR in response to replication stress, Xenopus tropicalis"
xref: Reactome:REACT_105467 "Loading of claspin onto DNA during replication origin firing, Danio rerio"
xref: Reactome:REACT_105835 "Stalling of DNA replication fork and RPA binding, Gallus gallus"
xref: Reactome:REACT_106018 "Recruitment of Rad17-RFC complex to DNA, Gallus gallus"
xref: Reactome:REACT_106104 "Binding of ATR-ATRIP to the RPA-ssDNA complex, Bos taurus"
xref: Reactome:REACT_106382 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Drosophila melanogaster"
xref: Reactome:REACT_106434 "Activation of claspin, Canis familiaris"
xref: Reactome:REACT_106732 "Recruitment and activation of Chk1, Canis familiaris"
xref: Reactome:REACT_107075 "Activation of ATR in response to replication stress, Danio rerio"
xref: Reactome:REACT_107423 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Caenorhabditis elegans"
xref: Reactome:REACT_108461 "Recruitment and activation of Chk1, Bos taurus"
xref: Reactome:REACT_108634 "Loading of claspin onto DNA during replication origin firing, Mus musculus"
xref: Reactome:REACT_108739 "Binding of ATR-ATRIP to the RPA-ssDNA complex, Xenopus tropicalis"
xref: Reactome:REACT_108768 "Activation of ATR in response to replication stress, Bos taurus"
xref: Reactome:REACT_108929 "Activation of ATR in response to replication stress, Drosophila melanogaster"
xref: Reactome:REACT_109137 "Stalling of DNA replication fork and RPA binding, Rattus norvegicus"
xref: Reactome:REACT_112472 "Activation of ATR in response to replication stress, Saccharomyces cerevisiae"
xref: Reactome:REACT_113703 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Gallus gallus"
xref: Reactome:REACT_29423 "Activation of ATR in response to replication stress, Schizosaccharomyces pombe"
xref: Reactome:REACT_29444 "Binding of ATR-ATRIP to the RPA-ssDNA complex, Taeniopygia guttata"
xref: Reactome:REACT_29691 "Activation of ATR in response to replication stress, Rattus norvegicus"
xref: Reactome:REACT_29764 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Taeniopygia guttata"
xref: Reactome:REACT_30149 "Activation of claspin, Rattus norvegicus"
xref: Reactome:REACT_31024 "Recruitment of Rad17-RFC complex to DNA, Xenopus tropicalis"
xref: Reactome:REACT_31919 "Loading of claspin onto DNA during replication origin firing, Rattus norvegicus"
xref: Reactome:REACT_32546 "Recruitment of Rad17-RFC complex to DNA, Mus musculus"
xref: Reactome:REACT_32932 "Recruitment and activation of Chk1, Taeniopygia guttata"
xref: Reactome:REACT_33572 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Dictyostelium discoideum"
xref: Reactome:REACT_33874 "Recruitment and activation of Chk1, Xenopus tropicalis"
xref: Reactome:REACT_50018 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Rattus norvegicus"
xref: Reactome:REACT_53588 "Loading of claspin onto DNA during replication origin firing, Canis familiaris"
xref: Reactome:REACT_6729 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Homo sapiens"
xref: Reactome:REACT_6738 "Loading of claspin onto DNA during replication origin firing, Homo sapiens"
xref: Reactome:REACT_6750 "Activation of claspin, Homo sapiens"
xref: Reactome:REACT_6769 "Activation of ATR in response to replication stress, Homo sapiens"
xref: Reactome:REACT_6798 "Recruitment of Rad17-RFC complex to DNA, Homo sapiens"
xref: Reactome:REACT_6869 "Recruitment and activation of Chk1, Homo sapiens"
xref: Reactome:REACT_6936 "Stalling of DNA replication fork and RPA binding, Homo sapiens"
xref: Reactome:REACT_6939 "Binding of ATR-ATRIP to the RPA-ssDNA complex, Homo sapiens"
xref: Reactome:REACT_77532 "Stalling of DNA replication fork and RPA binding, Canis familiaris"
xref: Reactome:REACT_79188 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Canis familiaris"
xref: Reactome:REACT_79450 "Activation of ATR in response to replication stress, Dictyostelium discoideum"
xref: Reactome:REACT_80432 "Loading of claspin onto DNA during replication origin firing, Taeniopygia guttata"
xref: Reactome:REACT_80571 "Activation of claspin, Mus musculus"
xref: Reactome:REACT_80896 "Recruitment and activation of Chk1, Sus scrofa"
xref: Reactome:REACT_80988 "Loading of claspin onto DNA during replication origin firing, Bos taurus"
xref: Reactome:REACT_81803 "Recruitment of Rad17-RFC complex to DNA, Canis familiaris"
xref: Reactome:REACT_83095 "Recruitment of Rad17-RFC complex to DNA, Danio rerio"
xref: Reactome:REACT_84829 "Binding of ATR-ATRIP to the RPA-ssDNA complex, Danio rerio"
xref: Reactome:REACT_85561 "Binding of ATR-ATRIP to the RPA-ssDNA complex, Rattus norvegicus"
xref: Reactome:REACT_86410 "Stalling of DNA replication fork and RPA binding, Mus musculus"
xref: Reactome:REACT_86739 "Recruitment and activation of Chk1, Rattus norvegicus"
xref: Reactome:REACT_87233 "Binding of ATR-ATRIP to the RPA-ssDNA complex, Canis familiaris"
xref: Reactome:REACT_87449 "Recruitment of Rad17-RFC complex to DNA, Rattus norvegicus"
xref: Reactome:REACT_87590 "Recruitment of Rad17-RFC complex to DNA, Bos taurus"
xref: Reactome:REACT_88085 "Binding of ATR-ATRIP to the RPA-ssDNA complex, Gallus gallus"
xref: Reactome:REACT_88384 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Schizosaccharomyces pombe"
xref: Reactome:REACT_88529 "Activation of claspin, Gallus gallus"
xref: Reactome:REACT_89355 "Activation of claspin, Danio rerio"
xref: Reactome:REACT_89439 "Activation of ATR in response to replication stress, Sus scrofa"
xref: Reactome:REACT_89725 "Loading of claspin onto DNA during replication origin firing, Drosophila melanogaster"
xref: Reactome:REACT_90512 "Stalling of DNA replication fork and RPA binding, Bos taurus"
xref: Reactome:REACT_90809 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Danio rerio"
xref: Reactome:REACT_90838 "Recruitment of Rad17-RFC complex to DNA, Taeniopygia guttata"
xref: Reactome:REACT_91184 "Recruitment and activation of Chk1, Danio rerio"
xref: Reactome:REACT_91302 "Activation of ATR in response to replication stress, Canis familiaris"
xref: Reactome:REACT_92527 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Mus musculus"
xref: Reactome:REACT_92644 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Xenopus tropicalis"
xref: Reactome:REACT_92706 "Stalling of DNA replication fork and RPA binding, Danio rerio"
xref: Reactome:REACT_94983 "Stalling of DNA replication fork and RPA binding, Xenopus tropicalis"
xref: Reactome:REACT_95253 "Activation of ATR in response to replication stress, Taeniopygia guttata"
xref: Reactome:REACT_95329 "Activation of claspin, Taeniopygia guttata"
xref: Reactome:REACT_96115 "Binding of ATR-ATRIP to the RPA-ssDNA complex, Mus musculus"
xref: Reactome:REACT_96804 "Recruitment and activation of Chk1, Mus musculus"
xref: Reactome:REACT_96998 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Bos taurus"
xref: Reactome:REACT_97204 "Loading of claspin onto DNA during replication origin firing, Gallus gallus"
xref: Reactome:REACT_97726 "Activation of ATR in response to replication stress, Caenorhabditis elegans"
xref: Reactome:REACT_99948 "Loading of claspin onto DNA during replication origin firing, Xenopus tropicalis"
xref: Wikipedia:DNA_replication
is_a: GO:0006259 ! DNA metabolic process
is_a: GO:0034645 ! cellular macromolecule biosynthetic process
relationship: has_part GO:0071897 ! DNA biosynthetic process

[Term]
id: GO:0006261
name: DNA-dependent DNA replication
namespace: biological_process
alt_id: GO:0006262
alt_id: GO:0006263
def: "A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0006260 ! DNA replication

[Term]
id: GO:0006264
name: mitochondrial DNA replication
namespace: biological_process
def: "The process in which new strands of DNA are synthesized in the mitochondrion." [GOC:ai]
synonym: "mitochondrial DNA synthesis" RELATED []
synonym: "mtDNA replication" EXACT []
synonym: "mtDNA synthesis" RELATED []
synonym: "replication of mitochondrial DNA" EXACT []
is_a: GO:0006261 ! DNA-dependent DNA replication
is_a: GO:0032042 ! mitochondrial DNA metabolic process
intersection_of: GO:0006260 ! DNA replication
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion

[Term]
id: GO:0006265
name: DNA topological change
namespace: biological_process
def: "The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number." [ISBN:071673706X, ISBN:0935702490]
comment: Note that the synonym 'DNA underwinding' should not be confused with 'DNA unwinding ; GO:0006268', which refers to DNA strand separation, and is a type of geometric change. GO:0006265 refers to alteration of the superhelical density of double-stranded DNA. Note that DNA topological change and DNA geometric change (GO:0032392) are distinct, but are usually coupled in vivo.
subset: gosubset_prok
synonym: "DNA underwinding" NARROW []
is_a: GO:0006259 ! DNA metabolic process
is_a: GO:0071103 ! DNA conformation change

[Term]
id: GO:0006266
name: DNA ligation
namespace: biological_process
def: "The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase." [ISBN:0815316194]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0006259 ! DNA metabolic process

[Term]
id: GO:0006267
name: pre-replicative complex assembly involved in nuclear cell cycle DNA replication
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the nuclear pre-replicative complex, a protein-DNA complex that forms at the eukaryotic DNA replication origin and is required for replication initiation." [GOC:mtg_cell_cycle]
synonym: "nuclear pre-replicative complex assembly" EXACT []
synonym: "pre-RC complex assembly" BROAD []
synonym: "pre-replicative complex assembly" BROAD [GOC:bf, GOC:bhm, GOC:jh2]
synonym: "pre-replicative complex formation" BROAD []
is_a: GO:1902299 ! pre-replicative complex assembly involved in cell cycle DNA replication
relationship: part_of GO:0033260 ! nuclear DNA replication

[Term]
id: GO:0006268
name: DNA unwinding involved in DNA replication
namespace: biological_process
def: "The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication." [ISBN:071673706X, ISBN:0815316194]
comment: Note that this term refers to a geometric change in DNA conformation, and should not be confused with 'DNA topological change ; GO:0006265'.
subset: gosubset_prok
synonym: "DNA unwinding during replication" RELATED [GOC:dph, GOC:tb]
synonym: "DNA unwinding factor" RELATED []
is_a: GO:0032508 ! DNA duplex unwinding
intersection_of: GO:0032508 ! DNA duplex unwinding
intersection_of: part_of GO:0006261 ! DNA-dependent DNA replication
relationship: part_of GO:0006261 ! DNA-dependent DNA replication

[Term]
id: GO:0006269
name: DNA replication, synthesis of RNA primer
namespace: biological_process
def: "The synthesis of a short RNA polymer, usually 4-15 nucleotides long, using one strand of unwound DNA as a template; the RNA then serves as a primer from which DNA polymerases extend synthesis." [PMID:11395402]
subset: gosubset_prok
synonym: "replication priming" RELATED []
is_a: GO:0006259 ! DNA metabolic process
is_a: GO:0032774 ! RNA biosynthetic process
relationship: part_of GO:0006261 ! DNA-dependent DNA replication

[Term]
id: GO:0006270
name: DNA replication initiation
namespace: biological_process
alt_id: GO:0042024
def: "The process in which DNA-dependent DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action." [ISBN:071673706X, ISBN:0815316194]
subset: gosubset_prok
synonym: "DNA endoreduplication initiation" NARROW []
synonym: "DNA re-replication initiation" NARROW []
synonym: "DNA-dependent DNA replication initiation" EXACT [GOC:vw]
xref: Reactome:REACT_102345 "DNA replication initiation, Plasmodium falciparum"
xref: Reactome:REACT_104509 "DNA replication initiation, Caenorhabditis elegans"
xref: Reactome:REACT_2244 "DNA replication initiation, Homo sapiens"
xref: Reactome:REACT_29293 "DNA replication initiation, Bos taurus"
xref: Reactome:REACT_30671 "DNA replication initiation, Arabidopsis thaliana"
xref: Reactome:REACT_31785 "DNA replication initiation, Xenopus tropicalis"
xref: Reactome:REACT_51432 "DNA replication initiation, Mus musculus"
xref: Reactome:REACT_77017 "DNA replication initiation, Sus scrofa"
xref: Reactome:REACT_80370 "DNA replication initiation, Dictyostelium discoideum"
xref: Reactome:REACT_89418 "DNA replication initiation, Saccharomyces cerevisiae"
xref: Reactome:REACT_89696 "DNA replication initiation, Danio rerio"
xref: Reactome:REACT_94747 "DNA replication initiation, Schizosaccharomyces pombe"
xref: Reactome:REACT_95351 "DNA replication initiation, Oryza sativa"
xref: Reactome:REACT_96273 "DNA replication initiation, Canis familiaris"
xref: Reactome:REACT_97560 "DNA replication initiation, Drosophila melanogaster"
xref: Reactome:REACT_97787 "DNA replication initiation, Rattus norvegicus"
is_a: GO:0006259 ! DNA metabolic process
relationship: part_of GO:0006261 ! DNA-dependent DNA replication

[Term]
id: GO:0006271
name: DNA strand elongation involved in DNA replication
namespace: biological_process
def: "The process in which a DNA strand is synthesized from template DNA during replication by the action of polymerases, which add nucleotides to the 3' end of the nascent DNA strand." [ISBN:071673706X, ISBN:0815316194]
subset: gosubset_prok
synonym: "DNA replication elongation" EXACT []
synonym: "DNA strand elongation during DNA replication" RELATED [GOC:dph, GOC:tb]
xref: Reactome:REACT_100837 "DNA strand elongation, Schizosaccharomyces pombe"
xref: Reactome:REACT_102588 "DNA strand elongation, Canis familiaris"
xref: Reactome:REACT_103840 "DNA strand elongation, Danio rerio"
xref: Reactome:REACT_104474 "DNA strand elongation, Mus musculus"
xref: Reactome:REACT_107311 "DNA strand elongation, Saccharomyces cerevisiae"
xref: Reactome:REACT_30657 "DNA strand elongation, Rattus norvegicus"
xref: Reactome:REACT_76948 "DNA strand elongation, Plasmodium falciparum"
xref: Reactome:REACT_83094 "DNA strand elongation, Caenorhabditis elegans"
xref: Reactome:REACT_83610 "DNA strand elongation, Dictyostelium discoideum"
xref: Reactome:REACT_84115 "DNA strand elongation, Oryza sativa"
xref: Reactome:REACT_84140 "DNA strand elongation, Drosophila melanogaster"
xref: Reactome:REACT_85176 "DNA strand elongation, Mycobacterium tuberculosis"
xref: Reactome:REACT_85667 "DNA strand elongation, Arabidopsis thaliana"
xref: Reactome:REACT_88125 "DNA strand elongation, Bos taurus"
xref: Reactome:REACT_92780 "DNA strand elongation, Gallus gallus"
xref: Reactome:REACT_932 "DNA strand elongation, Homo sapiens"
xref: Reactome:REACT_95055 "DNA strand elongation, Sus scrofa"
xref: Reactome:REACT_99290 "DNA strand elongation, Xenopus tropicalis"
xref: Reactome:REACT_99340 "DNA strand elongation, Taeniopygia guttata"
is_a: GO:0022616 ! DNA strand elongation
intersection_of: GO:0022616 ! DNA strand elongation
intersection_of: part_of GO:0006260 ! DNA replication
relationship: part_of GO:0006260 ! DNA replication
relationship: part_of GO:0006261 ! DNA-dependent DNA replication

[Term]
id: GO:0006272
name: leading strand elongation
namespace: biological_process
def: "The synthesis of DNA from a template strand in the 5' to 3' direction; leading strand elongation is continuous as it proceeds in the same direction as the replication fork." [ISBN:071673706X, ISBN:0815316194]
subset: gosubset_prok
is_a: GO:0006271 ! DNA strand elongation involved in DNA replication
is_a: GO:0016070 ! RNA metabolic process
relationship: has_part GO:0006269 ! DNA replication, synthesis of RNA primer

[Term]
id: GO:0006273
name: lagging strand elongation
namespace: biological_process
def: "The synthesis of DNA from a template strand in a net 3' to 5' direction. Lagging strand DNA elongation proceeds by discontinuous synthesis of short stretches of DNA, known as Okazaki fragments, from RNA primers; these fragments are then joined by DNA ligase. Although each segment of nascent DNA is synthesized in the 5' to 3' direction, the overall direction of lagging strand synthesis is 3' to 5', mirroring the progress of the replication fork." [ISBN:071673706X, ISBN:0815316194]
subset: gosubset_prok
is_a: GO:0006271 ! DNA strand elongation involved in DNA replication
is_a: GO:0016070 ! RNA metabolic process
relationship: has_part GO:0006269 ! DNA replication, synthesis of RNA primer

[Term]
id: GO:0006274
name: DNA replication termination
namespace: biological_process
def: "The process in which DNA replication at a replication fork ceases; occurs when the replication fork reaches a specific termination site or when two replication forks meet." [GOC:mah, PMID:10209736, PMID:12009298]
subset: gosubset_prok
is_a: GO:0006259 ! DNA metabolic process
relationship: part_of GO:0006261 ! DNA-dependent DNA replication

[Term]
id: GO:0006275
name: regulation of DNA replication
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA replication." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0051052 ! regulation of DNA metabolic process
is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006260 ! DNA replication
relationship: regulates GO:0006260 ! DNA replication

[Term]
id: GO:0006276
name: plasmid maintenance
namespace: biological_process
def: "The maintenance of the integrity of extrachromosomal plasmid DNA; includes processes that ensure plasmids are retained in the daughter cells after cell division." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0006277
name: DNA amplification
namespace: biological_process
def: "The process in which the number of copies of a gene is increased in certain cells as extra copies of DNA are made in response to certain signals of cell development or of stress from the environment." [ISBN:0721601464]
subset: gosubset_prok
is_a: GO:0071897 ! DNA biosynthetic process

[Term]
id: GO:0006278
name: RNA-dependent DNA biosynthetic process
namespace: biological_process
def: "A DNA biosynthetic process that uses RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strand." [GOC:mah, ISBN:0198506732]
subset: gosubset_prok
xref: Reactome:REACT_6880 "Reverse Transcription of HIV RNA, Homo sapiens"
xref: Reactome:REACT_9037 "Plus-strand DNA synthesis, Homo sapiens"
xref: Reactome:REACT_9055 "Minus-strand DNA synthesis, Homo sapiens"
is_a: GO:0071897 ! DNA biosynthetic process

[Term]
id: GO:0006279
name: premeiotic DNA replication
namespace: biological_process
alt_id: GO:1902968
def: "The replication of DNA that precedes meiotic cell division." [GO_REF:0000060, GOC:ai, GOC:TermGenie]
synonym: "DNA replication during S phase involved in meiotic cell cycle" RELATED [GOC:TermGenie]
synonym: "DNA replication involved in S phase involved in meiotic cell cycle" EXACT [GOC:TermGenie]
synonym: "DNA replication involved in S-phase involved in meiotic cell cycle" EXACT [GOC:TermGenie]
synonym: "meiotic cell cycle DNA replication" EXACT []
synonym: "meiotic DNA replication" RELATED [GOC:mah]
synonym: "meiotic DNA synthesis" RELATED [GOC:mah]
synonym: "meiotic nuclear cell cycle DNA replication" EXACT []
synonym: "nuclear cell cycle DNA replication involved in meiotic cell cycle" EXACT []
synonym: "premeiotic DNA synthesis" RELATED [GOC:mah]
is_a: GO:0033260 ! nuclear DNA replication
is_a: GO:1903046 ! meiotic cell cycle process
intersection_of: GO:0033260 ! nuclear DNA replication
intersection_of: part_of GO:0051321 ! meiotic cell cycle
relationship: part_of GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0006280
name: obsolete mutagenesis
namespace: biological_process
def: "OBSOLETE. The process by which genetic material undergoes a detectable and heritable structural change. There are three categories of mutation: genome mutations, involving addition or subtraction of one or more whole chromosomes; chromosome mutations, which alter the structure of chromosomes; and gene mutations, where the structure of a gene is altered at the molecular level." [ISBN:0198506732]
comment: This term was made obsolete because mutagenesis is not a valid biological process in which gene products would normally participate. Rather, mutations arise from DNA replication errors or damage by an extrinsic agent.
subset: gosubset_prok
synonym: "mutagenesis" EXACT []
is_obsolete: true
consider: GO:0006281
consider: GO:0051276

[Term]
id: GO:0006281
name: DNA repair
namespace: biological_process
def: "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
subset: goslim_pir
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
xref: Reactome:REACT_102034 "DNA Repair, Staphylococcus aureus N315"
xref: Reactome:REACT_106650 "DNA Damage Reversal, Taeniopygia guttata"
xref: Reactome:REACT_107446 "DNA Repair, Arabidopsis thaliana"
xref: Reactome:REACT_107692 "DNA Damage Reversal, Gallus gallus"
xref: Reactome:REACT_107752 "DNA Repair, Plasmodium falciparum"
xref: Reactome:REACT_108864 "DNA Damage Reversal, Rattus norvegicus"
xref: Reactome:REACT_108881 "DNA Damage Reversal, Bos taurus"
xref: Reactome:REACT_108903 "DNA Repair, Xenopus tropicalis"
xref: Reactome:REACT_109956 "DNA Repair, Gallus gallus"
xref: Reactome:REACT_115642 "DNA repair, Gallus gallus"
xref: Reactome:REACT_115836 "Fanconi Anemia Pathway in DNA repair, Gallus gallus"
xref: Reactome:REACT_127 "DNA Damage Reversal, Homo sapiens"
xref: Reactome:REACT_216 "DNA Repair, Homo sapiens"
xref: Reactome:REACT_29531 "DNA Damage Reversal, Saccharomyces cerevisiae"
xref: Reactome:REACT_29636 "DNA Damage Reversal, Staphylococcus aureus N315"
xref: Reactome:REACT_78051 "DNA Damage Reversal, Canis familiaris"
xref: Reactome:REACT_82907 "DNA Repair, Oryza sativa"
xref: Reactome:REACT_83608 "DNA Damage Reversal, Caenorhabditis elegans"
xref: Reactome:REACT_83660 "DNA Repair, Escherichia coli"
xref: Reactome:REACT_84835 "DNA Damage Reversal, Dictyostelium discoideum"
xref: Reactome:REACT_85522 "DNA Repair, Mus musculus"
xref: Reactome:REACT_86513 "DNA Repair, Mycobacterium tuberculosis"
xref: Reactome:REACT_86902 "DNA Repair, Danio rerio"
xref: Reactome:REACT_88201 "DNA Repair, Drosophila melanogaster"
xref: Reactome:REACT_88946 "DNA Damage Reversal, Mycobacterium tuberculosis"
xref: Reactome:REACT_89524 "DNA Damage Reversal, Drosophila melanogaster"
xref: Reactome:REACT_90385 "DNA Repair, Canis familiaris"
xref: Reactome:REACT_90952 "DNA Damage Reversal, Arabidopsis thaliana"
xref: Reactome:REACT_91094 "DNA Repair, Rattus norvegicus"
xref: Reactome:REACT_91330 "DNA Repair, Bos taurus"
xref: Reactome:REACT_91442 "DNA Repair, Caenorhabditis elegans"
xref: Reactome:REACT_91576 "DNA Damage Reversal, Oryza sativa"
xref: Reactome:REACT_92707 "DNA Repair, Taeniopygia guttata"
xref: Reactome:REACT_93704 "DNA Repair, Saccharomyces cerevisiae"
xref: Reactome:REACT_94204 "DNA Repair, Sus scrofa"
xref: Reactome:REACT_94769 "DNA Repair, Schizosaccharomyces pombe"
xref: Reactome:REACT_95050 "DNA Damage Reversal, Sus scrofa"
xref: Reactome:REACT_95158 "DNA Damage Reversal, Xenopus tropicalis"
xref: Reactome:REACT_96052 "DNA Repair, Dictyostelium discoideum"
xref: Reactome:REACT_96452 "DNA Damage Reversal, Danio rerio"
xref: Reactome:REACT_99277 "DNA Damage Reversal, Mus musculus"
xref: Wikipedia:DNA_repair
is_a: GO:0006259 ! DNA metabolic process
is_a: GO:0006974 ! cellular response to DNA damage stimulus
is_a: GO:0044710 ! single-organism metabolic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0006282
name: regulation of DNA repair
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA repair." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0051052 ! regulation of DNA metabolic process
is_a: GO:2001020 ! regulation of response to DNA damage stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006281 ! DNA repair
relationship: regulates GO:0006281 ! DNA repair

[Term]
id: GO:0006283
name: transcription-coupled nucleotide-excision repair
namespace: biological_process
def: "The nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway." [PMID:10197977, PMID:11900249]
subset: gosubset_prok
synonym: "TC-NER" EXACT [PMID:10197977]
synonym: "TCR" RELATED [GOC:vw, PMID:18794354]
synonym: "transcription-coupled NER" EXACT [GOC:mah]
synonym: "transcription-coupled repair" EXACT [GOC:vw, PMID:18794354]
xref: Reactome:REACT_100112 "Transcription-coupled NER (TC-NER), Schizosaccharomyces pombe"
xref: Reactome:REACT_108098 "Transcription-coupled NER (TC-NER), Canis familiaris"
xref: Reactome:REACT_108373 "Transcription-coupled NER (TC-NER), Mycobacterium tuberculosis"
xref: Reactome:REACT_108861 "Transcription-coupled NER (TC-NER), Plasmodium falciparum"
xref: Reactome:REACT_1628 "Transcription-coupled NER (TC-NER), Homo sapiens"
xref: Reactome:REACT_29182 "Transcription-coupled NER (TC-NER), Caenorhabditis elegans"
xref: Reactome:REACT_29721 "Transcription-coupled NER (TC-NER), Drosophila melanogaster"
xref: Reactome:REACT_33626 "Transcription-coupled NER (TC-NER), Taeniopygia guttata"
xref: Reactome:REACT_38724 "Transcription-coupled NER (TC-NER), Rattus norvegicus"
xref: Reactome:REACT_77091 "Transcription-coupled NER (TC-NER), Sus scrofa"
xref: Reactome:REACT_77494 "Transcription-coupled NER (TC-NER), Bos taurus"
xref: Reactome:REACT_79522 "Transcription-coupled NER (TC-NER), Xenopus tropicalis"
xref: Reactome:REACT_80476 "Transcription-coupled NER (TC-NER), Danio rerio"
xref: Reactome:REACT_81637 "Transcription-coupled NER (TC-NER), Dictyostelium discoideum"
xref: Reactome:REACT_86922 "Transcription-coupled NER (TC-NER), Gallus gallus"
xref: Reactome:REACT_87141 "Transcription-coupled NER (TC-NER), Saccharomyces cerevisiae"
xref: Reactome:REACT_91728 "Transcription-coupled NER (TC-NER), Mus musculus"
xref: Reactome:REACT_93719 "Transcription-coupled NER (TC-NER), Oryza sativa"
xref: Reactome:REACT_96116 "Transcription-coupled NER (TC-NER), Arabidopsis thaliana"
is_a: GO:0006289 ! nucleotide-excision repair

[Term]
id: GO:0006284
name: base-excision repair
namespace: biological_process
def: "In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194]
subset: gosubset_prok
synonym: "BER" EXACT []
xref: Reactome:REACT_104611 "Base Excision Repair, Schizosaccharomyces pombe"
xref: Reactome:REACT_105824 "Base Excision Repair, Drosophila melanogaster"
xref: Reactome:REACT_107274 "Base Excision Repair, Plasmodium falciparum"
xref: Reactome:REACT_108592 "Base Excision Repair, Mus musculus"
xref: Reactome:REACT_1104 "Base Excision Repair, Homo sapiens"
xref: Reactome:REACT_115956 "Base Excision Repair, Gallus gallus"
xref: Reactome:REACT_116144 "Resolution of Abasic Sites (AP sites), Gallus gallus"
xref: Reactome:REACT_28342 "Base Excision Repair, Arabidopsis thaliana"
xref: Reactome:REACT_30419 "Base Excision Repair, Rattus norvegicus"
xref: Reactome:REACT_34413 "Base Excision Repair, Caenorhabditis elegans"
xref: Reactome:REACT_77714 "Base Excision Repair, Mycobacterium tuberculosis"
xref: Reactome:REACT_78654 "Base Excision Repair, Danio rerio"
xref: Reactome:REACT_78880 "Base Excision Repair, Staphylococcus aureus N315"
xref: Reactome:REACT_79614 "Base Excision Repair, Bos taurus"
xref: Reactome:REACT_83441 "Base Excision Repair, Saccharomyces cerevisiae"
xref: Reactome:REACT_88635 "Base Excision Repair, Sus scrofa"
xref: Reactome:REACT_90283 "Base Excision Repair, Taeniopygia guttata"
xref: Reactome:REACT_91955 "Base Excision Repair, Dictyostelium discoideum"
xref: Reactome:REACT_94942 "Base Excision Repair, Escherichia coli"
xref: Reactome:REACT_94995 "Base Excision Repair, Xenopus tropicalis"
xref: Reactome:REACT_96321 "Base Excision Repair, Gallus gallus"
xref: Reactome:REACT_97901 "Base Excision Repair, Canis familiaris"
xref: Reactome:REACT_99288 "Base Excision Repair, Oryza sativa"
xref: Wikipedia:Base_excision_repair
is_a: GO:0006281 ! DNA repair

[Term]
id: GO:0006285
name: base-excision repair, AP site formation
namespace: biological_process
def: "The formation of an AP site, a deoxyribose sugar with a missing base, by DNA glycosylase which recognizes an altered base in DNA and catalyzes its hydrolytic removal. This sugar phosphate is the substrate recognized by the AP endonuclease, which cuts the DNA phosphodiester backbone at the 5' side of the altered site to leave a gap which is subsequently repaired." [ISBN:0815316194]
subset: gosubset_prok
xref: Reactome:REACT_100657 "Base-Excision Repair, AP Site Formation, Schizosaccharomyces pombe"
xref: Reactome:REACT_102528 "Base-Excision Repair, AP Site Formation, Mus musculus"
xref: Reactome:REACT_106177 "Base-Excision Repair, AP Site Formation, Dictyostelium discoideum"
xref: Reactome:REACT_107415 "Base-Excision Repair, AP Site Formation, Plasmodium falciparum"
xref: Reactome:REACT_115973 "Base Excision Repair, AP site formation, Gallus gallus"
xref: Reactome:REACT_28549 "Base-Excision Repair, AP Site Formation, Taeniopygia guttata"
xref: Reactome:REACT_28585 "Base-Excision Repair, AP Site Formation, Gallus gallus"
xref: Reactome:REACT_33245 "Base-Excision Repair, AP Site Formation, Oryza sativa"
xref: Reactome:REACT_77601 "Base-Excision Repair, AP Site Formation, Rattus norvegicus"
xref: Reactome:REACT_79521 "Base-Excision Repair, AP Site Formation, Sus scrofa"
xref: Reactome:REACT_80327 "Base-Excision Repair, AP Site Formation, Xenopus tropicalis"
xref: Reactome:REACT_804 "Base-Excision Repair, AP Site Formation, Homo sapiens"
xref: Reactome:REACT_81409 "Base-Excision Repair, AP Site Formation, Mycobacterium tuberculosis"
xref: Reactome:REACT_83884 "Base-Excision Repair, AP Site Formation, Drosophila melanogaster"
xref: Reactome:REACT_84949 "Base-Excision Repair, AP Site Formation, Caenorhabditis elegans"
xref: Reactome:REACT_87413 "Base-Excision Repair, AP Site Formation, Bos taurus"
xref: Reactome:REACT_88212 "Base-Excision Repair, AP Site Formation, Arabidopsis thaliana"
xref: Reactome:REACT_88725 "Base-Excision Repair, AP Site Formation, Staphylococcus aureus N315"
xref: Reactome:REACT_89749 "Base-Excision Repair, AP Site Formation, Danio rerio"
xref: Reactome:REACT_93909 "Base-Excision Repair, AP Site Formation, Saccharomyces cerevisiae"
xref: Reactome:REACT_93955 "Base-Excision Repair, AP Site Formation, Escherichia coli"
xref: Reactome:REACT_96638 "Base-Excision Repair, AP Site Formation, Canis familiaris"
is_a: GO:0006259 ! DNA metabolic process
relationship: part_of GO:0006284 ! base-excision repair

[Term]
id: GO:0006286
name: base-excision repair, base-free sugar-phosphate removal
namespace: biological_process
def: "Excision of the sugar phosphate residue at an AP site, i.e. a deoxyribose sugar with a missing base, by a phosphodiesterase enzyme." [ISBN:0815316194]
subset: gosubset_prok
xref: Reactome:REACT_103252 "Excision of the abasic sugar phosphate (dRP) residue at the strand break, Xenopus tropicalis"
xref: Reactome:REACT_1215 "Excision of the abasic sugar phosphate (dRP) residue at the strand break, Homo sapiens"
xref: Reactome:REACT_32396 "Excision of the abasic sugar phosphate (dRP) residue at the strand break, Rattus norvegicus"
xref: Reactome:REACT_55273 "Excision of the abasic sugar phosphate (dRP) residue at the strand break, Dictyostelium discoideum"
xref: Reactome:REACT_79844 "Excision of the abasic sugar phosphate (dRP) residue at the strand break, Mus musculus"
xref: Reactome:REACT_83849 "Excision of the abasic sugar phosphate (dRP) residue at the strand break, Danio rerio"
xref: Reactome:REACT_85754 "Excision of the abasic sugar phosphate (dRP) residue at the strand break, Sus scrofa"
xref: Reactome:REACT_96683 "Excision of the abasic sugar phosphate (dRP) residue at the strand break, Bos taurus"
xref: Reactome:REACT_97368 "Excision of the abasic sugar phosphate (dRP) residue at the strand break, Canis familiaris"
xref: Reactome:REACT_99910 "Excision of the abasic sugar phosphate (dRP) residue at the strand break, Taeniopygia guttata"
is_a: GO:0098502 ! DNA dephosphorylation
relationship: part_of GO:0006284 ! base-excision repair

[Term]
id: GO:0006287
name: base-excision repair, gap-filling
namespace: biological_process
def: "Repair of the damaged strand by the combined action of an apurinic endouclease that degrades a few bases on the damaged strand and a polymerase that synthesizes a 'patch' in the 5' to 3' direction, using the undamaged strand as a template." [ISBN:1550091131]
subset: gosubset_prok
is_a: GO:0006259 ! DNA metabolic process
relationship: part_of GO:0006284 ! base-excision repair

[Term]
id: GO:0006288
name: base-excision repair, DNA ligation
namespace: biological_process
def: "The ligation by DNA ligase of DNA strands. Ligation occurs after polymerase action to fill the gap left by the action of endonucleases during base-excision repair." [ISBN:1550091131]
subset: gosubset_prok
xref: Reactome:REACT_100095 "DNA ligation via the single-nucleotide replacement pathway, Bos taurus"
xref: Reactome:REACT_102989 "Ligation of DNA at sites of patch replacement, Rattus norvegicus"
xref: Reactome:REACT_107864 "DNA ligation via the single-nucleotide replacement pathway, Dictyostelium discoideum"
xref: Reactome:REACT_108675 "Ligation of DNA at sites of patch replacement, Mus musculus"
xref: Reactome:REACT_1247 "Ligation of DNA at sites of patch replacement, Homo sapiens"
xref: Reactome:REACT_1659 "DNA ligation via the single-nucleotide replacement pathway, Homo sapiens"
xref: Reactome:REACT_29882 "Ligation of DNA at sites of patch replacement, Xenopus tropicalis"
xref: Reactome:REACT_31800 "Ligation of DNA at sites of patch replacement, Sus scrofa"
xref: Reactome:REACT_82701 "DNA ligation via the single-nucleotide replacement pathway, Xenopus tropicalis"
xref: Reactome:REACT_83571 "Ligation of DNA at sites of patch replacement, Danio rerio"
xref: Reactome:REACT_87237 "Ligation of DNA at sites of patch replacement, Arabidopsis thaliana"
xref: Reactome:REACT_89311 "DNA ligation via the single-nucleotide replacement pathway, Mus musculus"
xref: Reactome:REACT_91447 "Ligation of DNA at sites of patch replacement, Canis familiaris"
xref: Reactome:REACT_91602 "DNA ligation via the single-nucleotide replacement pathway, Canis familiaris"
xref: Reactome:REACT_92807 "Ligation of DNA at sites of patch replacement, Bos taurus"
xref: Reactome:REACT_93826 "DNA ligation via the single-nucleotide replacement pathway, Danio rerio"
xref: Reactome:REACT_94103 "DNA ligation via the single-nucleotide replacement pathway, Rattus norvegicus"
xref: Reactome:REACT_98339 "Ligation of DNA at sites of patch replacement, Oryza sativa"
is_a: GO:0051103 ! DNA ligation involved in DNA repair
intersection_of: GO:0006266 ! DNA ligation
intersection_of: part_of GO:0006284 ! base-excision repair
relationship: part_of GO:0006284 ! base-excision repair

[Term]
id: GO:0006289
name: nucleotide-excision repair
namespace: biological_process
alt_id: GO:0045001
def: "A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977]
comment: Note that although intrastrand cross-link repair is not exactly synonymous with nucleotide excision repair, nucleotide excision repair includes the repair of intrastrand cross-links. The synonym field is being used to reflect the broad substrate specificity of nucleotide excision repair.
subset: gosubset_prok
synonym: "intrastrand cross-link repair" RELATED []
synonym: "NER" EXACT []
synonym: "pyrimidine-dimer repair, DNA damage excision" EXACT []
xref: Reactome:REACT_103880 "Nucleotide Excision Repair, Canis familiaris"
xref: Reactome:REACT_103962 "Nucleotide Excision Repair, Schizosaccharomyces pombe"
xref: Reactome:REACT_106982 "Nucleotide Excision Repair, Drosophila melanogaster"
xref: Reactome:REACT_109142 "Nucleotide Excision Repair, Rattus norvegicus"
xref: Reactome:REACT_110113 "Nucleotide Excision Repair, Plasmodium falciparum"
xref: Reactome:REACT_1826 "Nucleotide Excision Repair, Homo sapiens"
xref: Reactome:REACT_30685 "Nucleotide Excision Repair, Sus scrofa"
xref: Reactome:REACT_31605 "Nucleotide Excision Repair, Danio rerio"
xref: Reactome:REACT_71449 "Nucleotide Excision Repair, Gallus gallus"
xref: Reactome:REACT_77033 "Nucleotide Excision Repair, Oryza sativa"
xref: Reactome:REACT_79939 "Nucleotide Excision Repair, Xenopus tropicalis"
xref: Reactome:REACT_81923 "Nucleotide Excision Repair, Taeniopygia guttata"
xref: Reactome:REACT_84438 "Nucleotide Excision Repair, Caenorhabditis elegans"
xref: Reactome:REACT_85405 "Nucleotide Excision Repair, Dictyostelium discoideum"
xref: Reactome:REACT_88933 "Nucleotide Excision Repair, Saccharomyces cerevisiae"
xref: Reactome:REACT_91101 "Nucleotide Excision Repair, Mus musculus"
xref: Reactome:REACT_96106 "Nucleotide Excision Repair, Arabidopsis thaliana"
xref: Reactome:REACT_98428 "Nucleotide Excision Repair, Bos taurus"
xref: Reactome:REACT_98432 "Nucleotide Excision Repair, Mycobacterium tuberculosis"
is_a: GO:0006281 ! DNA repair

[Term]
id: GO:0006290
name: pyrimidine dimer repair
namespace: biological_process
def: "The repair of UV-induced T-T, C-T and C-C dimers." [ISBN:0815316194]
subset: gosubset_prok
is_a: GO:0006281 ! DNA repair

[Term]
id: GO:0006291
name: obsolete pyrimidine-dimer repair, DNA damage excision
namespace: biological_process
def: "OBSOLETE. The excision of damaged DNA during pyrimidine-dimer repair. A large multienzyme complex scans the DNA for a distortion in the double helix rather than for a specific base change. Once a bulky lesion is found, the phosphodiester backbone of the abnormal strand is cleaved on both sides of the distortion, and the portion of the strand containing the lesion (an oligonucleotide) is peeled away from the DNA double helix by a DNA helicase enzyme." [ISBN:0815316194]
comment: This term was made obsolete because this process can be subdivided into multiple processes.
synonym: "pyrimidine-dimer repair, DNA damage excision" EXACT []
is_obsolete: true
consider: GO:0006289

[Term]
id: GO:0006292
name: obsolete pyrimidine-dimer repair, DNA damage recognition
namespace: biological_process
def: "OBSOLETE. The location of pyrimidine dimers by a large multienzyme complex that scans the DNA for distortions in the double helix caused by pyrimidine dimers." [ISBN:0815316194]
comment: This term was made obsolete because it is a substrate specific DNA repair process.
synonym: "pyrimidine-dimer repair, DNA damage recognition" EXACT []
is_obsolete: true
consider: GO:0000715
consider: GO:0000716

[Term]
id: GO:0006293
name: nucleotide-excision repair, preincision complex stabilization
namespace: biological_process
def: "The stabilization of the multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage as well as the unwound DNA. The stabilization of the protein-DNA complex ensures proper positioning of the preincision complex before the phosphodiester backbone of the damaged strand is cleaved 3' and 5' of the site of DNA damage." [GOC:elh, PMID:10197977]
subset: gosubset_prok
xref: Reactome:REACT_100880 "Binding of ERCC1-XPF to preincision complex, Schizosaccharomyces pombe"
xref: Reactome:REACT_101859 "Binding of ERCC1-XPF to preincision complex, Oryza sativa"
xref: Reactome:REACT_105931 "Binding of ERCC1-XPF to preincision complex, Drosophila melanogaster"
xref: Reactome:REACT_114006 "Binding of ERCC1-XPF to preincision complex, Caenorhabditis elegans"
xref: Reactome:REACT_2163 "Binding of ERCC1-XPF to preincision complex, Homo sapiens"
xref: Reactome:REACT_28578 "Binding of ERCC1-XPF to preincision complex, Saccharomyces cerevisiae"
xref: Reactome:REACT_46939 "Binding of ERCC1-XPF to preincision complex, Canis familiaris"
xref: Reactome:REACT_80687 "Binding of ERCC1-XPF to preincision complex, Bos taurus"
xref: Reactome:REACT_84807 "Binding of ERCC1-XPF to preincision complex, Rattus norvegicus"
xref: Reactome:REACT_91797 "Binding of ERCC1-XPF to preincision complex, Danio rerio"
xref: Reactome:REACT_98634 "Binding of ERCC1-XPF to preincision complex, Mus musculus"
xref: Reactome:REACT_99635 "Binding of ERCC1-XPF to preincision complex, Arabidopsis thaliana"
xref: Reactome:REACT_99871 "Binding of ERCC1-XPF to preincision complex, Xenopus tropicalis"
is_a: GO:0031334 ! positive regulation of protein complex assembly
relationship: part_of GO:0006289 ! nucleotide-excision repair

[Term]
id: GO:0006294
name: nucleotide-excision repair, preincision complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins on DNA to form the multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage. This assembly occurs before the phosphodiester backbone of the damaged strand is cleaved 3' and 5' of the site of DNA damage." [GOC:elh, PMID:10197977]
subset: gosubset_prok
synonym: "nucleotide-excision repair, preincision complex formation" EXACT []
xref: Reactome:REACT_112711 "Recruitment of repair factors to form preincision complex, Xenopus tropicalis"
xref: Reactome:REACT_1492 "Recruitment of repair factors to form preincision complex, Homo sapiens"
xref: Reactome:REACT_77214 "Recruitment of repair factors to form preincision complex, Gallus gallus"
xref: Reactome:REACT_79636 "Recruitment of repair factors to form preincision complex, Taeniopygia guttata"
xref: Reactome:REACT_94021 "Recruitment of repair factors to form preincision complex, Rattus norvegicus"
xref: Reactome:REACT_94632 "Recruitment of repair factors to form preincision complex, Danio rerio"
xref: Reactome:REACT_96093 "Recruitment of repair factors to form preincision complex, Mus musculus"
is_a: GO:0065004 ! protein-DNA complex assembly
relationship: part_of GO:0006289 ! nucleotide-excision repair

[Term]
id: GO:0006295
name: nucleotide-excision repair, DNA incision, 3'-to lesion
namespace: biological_process
def: "The endonucleolytic cleavage of the damaged strand of DNA 3' to the site of damage. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The incision precedes the incision formed 5' to the site of damage." [GOC:elh, PMID:10197977]
subset: gosubset_prok
synonym: "nucleotide-excision repair, DNA incision, 3' to lesion" EXACT []
xref: Reactome:REACT_100654 "3'- incision of DNA by XPG in GG-NER, Arabidopsis thaliana"
xref: Reactome:REACT_101397 "3'- incision of DNA by XPG in GG-NER, Danio rerio"
xref: Reactome:REACT_103600 "3'- incision of DNA by XPG in GG-NER, Gallus gallus"
xref: Reactome:REACT_106502 "3'- incision of DNA by XPG in GG-NER, Rattus norvegicus"
xref: Reactome:REACT_108614 "3'- incision of DNA by XPG in GG-NER, Taeniopygia guttata"
xref: Reactome:REACT_110731 "3'- incision of DNA by XPG in GG-NER, Xenopus tropicalis"
xref: Reactome:REACT_1124 "3'- incision of DNA by XPG in GG-NER, Homo sapiens"
xref: Reactome:REACT_78624 "3'- incision of DNA by XPG in GG-NER, Canis familiaris"
xref: Reactome:REACT_80387 "3'- incision of DNA by XPG in GG-NER, Caenorhabditis elegans"
xref: Reactome:REACT_80628 "3'- incision of DNA by XPG in GG-NER, Saccharomyces cerevisiae"
xref: Reactome:REACT_80681 "3'- incision of DNA by XPG in GG-NER, Bos taurus"
xref: Reactome:REACT_81714 "3'- incision of DNA by XPG in GG-NER, Oryza sativa"
xref: Reactome:REACT_89800 "3'- incision of DNA by XPG in GG-NER, Schizosaccharomyces pombe"
xref: Reactome:REACT_90034 "3'- incision of DNA by XPG in GG-NER, Mus musculus"
xref: Reactome:REACT_90935 "3'- incision of DNA by XPG in GG-NER, Sus scrofa"
xref: Reactome:REACT_92894 "3'- incision of DNA by XPG in GG-NER, Drosophila melanogaster"
is_a: GO:0033683 ! nucleotide-excision repair, DNA incision

[Term]
id: GO:0006296
name: nucleotide-excision repair, DNA incision, 5'-to lesion
namespace: biological_process
def: "The endonucleolytic cleavage of the damaged strand of DNA 5' to the site of damage. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The incision follows the incision formed 3' to the site of damage." [GOC:elh, PMID:10197977]
subset: gosubset_prok
synonym: "nucleotide-excision repair, DNA incision, 5' to lesion" EXACT []
xref: Reactome:REACT_101184 "5'-incision of DNA by ERCC1-XPF in GG-NER, Danio rerio"
xref: Reactome:REACT_112122 "5'-incision of DNA by ERCC1-XPF in GG-NER, Xenopus tropicalis"
xref: Reactome:REACT_1311 "5'-incision of DNA by ERCC1-XPF in GG-NER, Homo sapiens"
xref: Reactome:REACT_83838 "5'-incision of DNA by ERCC1-XPF in GG-NER, Rattus norvegicus"
xref: Reactome:REACT_95903 "5'-incision of DNA by ERCC1-XPF in GG-NER, Mus musculus"
is_a: GO:0033683 ! nucleotide-excision repair, DNA incision

[Term]
id: GO:0006297
name: nucleotide-excision repair, DNA gap filling
namespace: biological_process
def: "Repair of the gap in the DNA helix by DNA polymerase and DNA ligase after the portion of the strand containing the lesion has been removed by pyrimidine-dimer repair enzymes." [ISBN:0815316194]
subset: gosubset_prok
xref: Reactome:REACT_102971 "Gap-filling DNA repair synthesis and ligation in GG-NER, Rattus norvegicus"
xref: Reactome:REACT_103287 "Gap-filling DNA repair synthesis and ligation in GG-NER, Canis familiaris"
xref: Reactome:REACT_105712 "Gap-filling DNA repair synthesis and ligation in GG-NER, Sus scrofa"
xref: Reactome:REACT_109672 "Gap-filling DNA repair synthesis and ligation in GG-NER, Taeniopygia guttata"
xref: Reactome:REACT_1998 "Gap-filling DNA repair synthesis and ligation in GG-NER, Homo sapiens"
xref: Reactome:REACT_30462 "Gap-filling DNA repair synthesis and ligation in GG-NER, Drosophila melanogaster"
xref: Reactome:REACT_73827 "Gap-filling DNA repair synthesis and ligation in GG-NER, Dictyostelium discoideum"
xref: Reactome:REACT_77836 "Gap-filling DNA repair synthesis and ligation in GG-NER, Caenorhabditis elegans"
xref: Reactome:REACT_79391 "Gap-filling DNA repair synthesis and ligation in GG-NER, Xenopus tropicalis"
xref: Reactome:REACT_80426 "Gap-filling DNA repair synthesis and ligation in GG-NER, Saccharomyces cerevisiae"
xref: Reactome:REACT_85790 "Gap-filling DNA repair synthesis and ligation in GG-NER, Mycobacterium tuberculosis"
xref: Reactome:REACT_88221 "Gap-filling DNA repair synthesis and ligation in GG-NER, Oryza sativa"
xref: Reactome:REACT_88596 "Gap-filling DNA repair synthesis and ligation in GG-NER, Bos taurus"
xref: Reactome:REACT_94346 "Gap-filling DNA repair synthesis and ligation in GG-NER, Danio rerio"
xref: Reactome:REACT_94671 "Gap-filling DNA repair synthesis and ligation in GG-NER, Schizosaccharomyces pombe"
xref: Reactome:REACT_95308 "Gap-filling DNA repair synthesis and ligation in GG-NER, Plasmodium falciparum"
xref: Reactome:REACT_96020 "Gap-filling DNA repair synthesis and ligation in GG-NER, Gallus gallus"
xref: Reactome:REACT_98841 "Gap-filling DNA repair synthesis and ligation in GG-NER, Mus musculus"
xref: Reactome:REACT_99787 "Gap-filling DNA repair synthesis and ligation in GG-NER, Arabidopsis thaliana"
is_a: GO:0006259 ! DNA metabolic process
relationship: part_of GO:0006289 ! nucleotide-excision repair

[Term]
id: GO:0006298
name: mismatch repair
namespace: biological_process
alt_id: GO:0006300
def: "A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886]
subset: gosubset_prok
synonym: "long patch mismatch repair system" NARROW []
synonym: "mismatch repair, MutL-like pathway" RELATED []
synonym: "MMR" EXACT []
synonym: "MutS/MutL/MutH pathway" RELATED []
xref: Wikipedia:DNA_mismatch_repair
is_a: GO:0006281 ! DNA repair

[Term]
id: GO:0006299
name: obsolete short patch mismatch repair system
namespace: biological_process
def: "OBSOLETE. The repair of mismatched DNA where the gap to be repaired is only one nucleotide. DNA polymerase is the preferred polymerase in short patch repair, performing gap filling DNA synthesis and removal of the 5'-deoxyribose phosphate of the abasic site." [PMID:10660619, PMID:10878254]
comment: This term was made obsolete because 'short patch' is a relative statement, often used ambiguously, and does not necessarily represent a process; the processes it can stand for are base excision repair, nucleotide excision repair, transcription-coupled nucleotide excision repair, and mismatch repair.
synonym: "short patch mismatch repair system" EXACT []
is_obsolete: true
consider: GO:0006284
consider: GO:0006289

[Term]
id: GO:0006301
name: postreplication repair
namespace: biological_process
def: "The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication. Includes pathways that remove replication-blocking lesions in conjunction with DNA replication." [GOC:elh]
subset: gosubset_prok
synonym: "postreplication DNA repair" EXACT [GOC:curators]
xref: Wikipedia:Postreplication_repair
is_a: GO:0006281 ! DNA repair

[Term]
id: GO:0006302
name: double-strand break repair
namespace: biological_process
def: "The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh]
comment: Note that the processes of nuclear double-strand break repair and mitochondrial double-strand break repair are genetically separable (PMID:22214610). To annotate gene products involved in mitochondrial double-strand break repair, please use GO:0097551 'mitochondrial double-strand break repair'.
subset: gosubset_prok
xref: Reactome:REACT_103570 "Double-Strand Break Repair, Mycobacterium tuberculosis"
xref: Reactome:REACT_103800 "Double-Strand Break Repair, Gallus gallus"
xref: Reactome:REACT_107286 "Double-Strand Break Repair, Canis familiaris"
xref: Reactome:REACT_116061 "Double strand break repair, Gallus gallus"
xref: Reactome:REACT_2054 "Double-Strand Break Repair, Homo sapiens"
xref: Reactome:REACT_30484 "Double-Strand Break Repair, Arabidopsis thaliana"
xref: Reactome:REACT_31577 "Double-Strand Break Repair, Schizosaccharomyces pombe"
xref: Reactome:REACT_33123 "Double-Strand Break Repair, Oryza sativa"
xref: Reactome:REACT_74735 "Double-Strand Break Repair, Dictyostelium discoideum"
xref: Reactome:REACT_77568 "Double-Strand Break Repair, Xenopus tropicalis"
xref: Reactome:REACT_79557 "Double-Strand Break Repair, Rattus norvegicus"
xref: Reactome:REACT_79999 "Double-Strand Break Repair, Plasmodium falciparum"
xref: Reactome:REACT_83524 "Double-Strand Break Repair, Taeniopygia guttata"
xref: Reactome:REACT_84402 "Double-Strand Break Repair, Saccharomyces cerevisiae"
xref: Reactome:REACT_85859 "Double-Strand Break Repair, Sus scrofa"
xref: Reactome:REACT_95411 "Double-Strand Break Repair, Mus musculus"
xref: Reactome:REACT_96237 "Double-Strand Break Repair, Drosophila melanogaster"
xref: Reactome:REACT_97002 "Double-Strand Break Repair, Caenorhabditis elegans"
xref: Reactome:REACT_97010 "Double-Strand Break Repair, Bos taurus"
xref: Reactome:REACT_97122 "Double-Strand Break Repair, Danio rerio"
is_a: GO:0006281 ! DNA repair

[Term]
id: GO:0006303
name: double-strand break repair via nonhomologous end joining
namespace: biological_process
def: "The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear." [GOC:rph, PMID:10827453, PMID:24837021]
subset: gosubset_prok
synonym: "NHEJ" EXACT []
xref: Reactome:REACT_100151 "Nonhomologous End-joining (NHEJ), Danio rerio"
xref: Reactome:REACT_1022 "Nonhomologous End-joining (NHEJ), Homo sapiens"
xref: Reactome:REACT_105598 "Nonhomologous End-joining (NHEJ), Mus musculus"
xref: Reactome:REACT_108059 "Nonhomologous End-joining (NHEJ), Arabidopsis thaliana"
xref: Reactome:REACT_108116 "Nonhomologous End-joining (NHEJ), Caenorhabditis elegans"
xref: Reactome:REACT_108372 "Nonhomologous End-joining (NHEJ), Sus scrofa"
xref: Reactome:REACT_109687 "Nonhomologous End-joining (NHEJ), Schizosaccharomyces pombe"
xref: Reactome:REACT_110441 "Nonhomologous End-joining (NHEJ), Oryza sativa"
xref: Reactome:REACT_114794 "Nonhomologous End-joining (NHEJ), Xenopus tropicalis"
xref: Reactome:REACT_115694 "Non-homologous end joining (NHEJ), Gallus gallus"
xref: Reactome:REACT_78453 "Nonhomologous End-joining (NHEJ), Dictyostelium discoideum"
xref: Reactome:REACT_79261 "Nonhomologous End-joining (NHEJ), Rattus norvegicus"
xref: Reactome:REACT_83788 "Nonhomologous End-joining (NHEJ), Taeniopygia guttata"
xref: Reactome:REACT_86175 "Nonhomologous End-joining (NHEJ), Drosophila melanogaster"
xref: Reactome:REACT_93170 "Nonhomologous End-joining (NHEJ), Gallus gallus"
xref: Reactome:REACT_93631 "Nonhomologous End-joining (NHEJ), Canis familiaris"
xref: Reactome:REACT_97194 "Nonhomologous End-joining (NHEJ), Bos taurus"
is_a: GO:0000726 ! non-recombinational repair
is_a: GO:0006302 ! double-strand break repair

[Term]
id: GO:0006304
name: DNA modification
namespace: biological_process
def: "The covalent alteration of one or more nucleotide sites in DNA, resulting in a change in its properties." [GOC:jl, GOC:ma]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0006259 ! DNA metabolic process
is_a: GO:0043412 ! macromolecule modification

[Term]
id: GO:0006305
name: DNA alkylation
namespace: biological_process
def: "The addition of alkyl groups to many positions on all four bases of DNA. Alkylating agents can also modify the bases of incoming nucleotides in the course of DNA synthesis." [ISBN:0716735970]
subset: gosubset_prok
is_a: GO:0006304 ! DNA modification

[Term]
id: GO:0006306
name: DNA methylation
namespace: biological_process
def: "The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine." [GOC:ems, ISBN:0198506732]
subset: gosubset_prok
xref: Wikipedia:DNA_methylation
is_a: GO:0006305 ! DNA alkylation
is_a: GO:0043414 ! macromolecule methylation
is_a: GO:0044728 ! DNA methylation or demethylation

[Term]
id: GO:0006307
name: DNA dealkylation involved in DNA repair
namespace: biological_process
def: "The repair of alkylation damage, e.g. the removal of the alkyl group at the O6-position of guanine by O6-alkylguanine-DNA alkyltransferase (AGT)." [PMID:10946226]
subset: gosubset_prok
xref: Reactome:REACT_101828 "ABH3 mediated Reversal of Alkylation Damage, Xenopus tropicalis"
xref: Reactome:REACT_102013 "ABH2 mediated Reversal of Alkylation Damage, Mus musculus"
xref: Reactome:REACT_102488 "MGMT/hAGT mediated DNA Damage Reversal, Canis familiaris"
xref: Reactome:REACT_103267 "MGMT/hAGT mediated DNA Damage Reversal, Gallus gallus"
xref: Reactome:REACT_103543 "MGMT/hAGT mediated DNA Damage Reversal, Dictyostelium discoideum"
xref: Reactome:REACT_103942 "ABH3 mediated Reversal of Alkylation Damage, Danio rerio"
xref: Reactome:REACT_104082 "ABH2 mediated Reversal of Alkylation Damage, Danio rerio"
xref: Reactome:REACT_104382 "MGMT/hAGT mediated DNA Damage Reversal, Taeniopygia guttata"
xref: Reactome:REACT_106933 "ABH3 mediated Reversal of Alkylation Damage, Taeniopygia guttata"
xref: Reactome:REACT_108289 "MGMT/hAGT mediated DNA Damage Reversal, Sus scrofa"
xref: Reactome:REACT_110715 "ABH2 mediated Reversal of Alkylation Damage, Sus scrofa"
xref: Reactome:REACT_113126 "ABH2 mediated Reversal of Alkylation Damage, Oryza sativa"
xref: Reactome:REACT_113979 "ABH2 mediated Reversal of Alkylation Damage, Arabidopsis thaliana"
xref: Reactome:REACT_115693 "DNA Damage Reversal, Gallus gallus"
xref: Reactome:REACT_1662 "ABH3 mediated Reversal of Alkylation Damage, Homo sapiens"
xref: Reactome:REACT_1876 "MGMT/hAGT mediated DNA Damage Reversal, Homo sapiens"
xref: Reactome:REACT_2020 "Reversal of Alkylation Damage By DNA Dioxygenases, Homo sapiens"
xref: Reactome:REACT_28063 "MGMT/hAGT mediated DNA Damage Reversal, Mus musculus"
xref: Reactome:REACT_29167 "MGMT/hAGT mediated DNA Damage Reversal, Mycobacterium tuberculosis"
xref: Reactome:REACT_30664 "Reversal of Alkylation Damage By DNA Dioxygenases, Mycobacterium tuberculosis"
xref: Reactome:REACT_30830 "Reversal of Alkylation Damage By DNA Dioxygenases, Canis familiaris"
xref: Reactome:REACT_30967 "ABH3 mediated Reversal of Alkylation Damage, Arabidopsis thaliana"
xref: Reactome:REACT_31652 "MGMT/hAGT mediated DNA Damage Reversal, Staphylococcus aureus N315"
xref: Reactome:REACT_33086 "Reversal of Alkylation Damage By DNA Dioxygenases, Arabidopsis thaliana"
xref: Reactome:REACT_34658 "Reversal of Alkylation Damage By DNA Dioxygenases, Xenopus tropicalis"
xref: Reactome:REACT_39723 "Reversal of Alkylation Damage By DNA Dioxygenases, Rattus norvegicus"
xref: Reactome:REACT_526 "ABH2 mediated Reversal of Alkylation Damage, Homo sapiens"
xref: Reactome:REACT_77089 "ABH3 mediated Reversal of Alkylation Damage, Mycobacterium tuberculosis"
xref: Reactome:REACT_79219 "ABH3 mediated Reversal of Alkylation Damage, Mus musculus"
xref: Reactome:REACT_79533 "Reversal of Alkylation Damage By DNA Dioxygenases, Gallus gallus"
xref: Reactome:REACT_80455 "ABH2 mediated Reversal of Alkylation Damage, Mycobacterium tuberculosis"
xref: Reactome:REACT_82211 "MGMT/hAGT mediated DNA Damage Reversal, Danio rerio"
xref: Reactome:REACT_84677 "Reversal of Alkylation Damage By DNA Dioxygenases, Oryza sativa"
xref: Reactome:REACT_84817 "ABH3 mediated Reversal of Alkylation Damage, Gallus gallus"
xref: Reactome:REACT_86699 "ABH2 mediated Reversal of Alkylation Damage, Rattus norvegicus"
xref: Reactome:REACT_87151 "Reversal of Alkylation Damage By DNA Dioxygenases, Taeniopygia guttata"
xref: Reactome:REACT_87639 "Reversal of Alkylation Damage By DNA Dioxygenases, Bos taurus"
xref: Reactome:REACT_87788 "ABH3 mediated Reversal of Alkylation Damage, Canis familiaris"
xref: Reactome:REACT_88561 "ABH3 mediated Reversal of Alkylation Damage, Bos taurus"
xref: Reactome:REACT_88563 "ABH3 mediated Reversal of Alkylation Damage, Rattus norvegicus"
xref: Reactome:REACT_89238 "MGMT/hAGT mediated DNA Damage Reversal, Saccharomyces cerevisiae"
xref: Reactome:REACT_90543 "Reversal of Alkylation Damage By DNA Dioxygenases, Sus scrofa"
xref: Reactome:REACT_90904 "ABH2 mediated Reversal of Alkylation Damage, Bos taurus"
xref: Reactome:REACT_91443 "ABH3 mediated Reversal of Alkylation Damage, Oryza sativa"
xref: Reactome:REACT_91524 "Reversal of Alkylation Damage By DNA Dioxygenases, Danio rerio"
xref: Reactome:REACT_91571 "ABH2 mediated Reversal of Alkylation Damage, Taeniopygia guttata"
xref: Reactome:REACT_92208 "MGMT/hAGT mediated DNA Damage Reversal, Drosophila melanogaster"
xref: Reactome:REACT_92393 "ABH2 mediated Reversal of Alkylation Damage, Gallus gallus"
xref: Reactome:REACT_93849 "ABH2 mediated Reversal of Alkylation Damage, Xenopus tropicalis"
xref: Reactome:REACT_94186 "Reversal of Alkylation Damage By DNA Dioxygenases, Mus musculus"
xref: Reactome:REACT_94426 "MGMT/hAGT mediated DNA Damage Reversal, Rattus norvegicus"
xref: Reactome:REACT_96080 "MGMT/hAGT mediated DNA Damage Reversal, Xenopus tropicalis"
xref: Reactome:REACT_98636 "MGMT/hAGT mediated DNA Damage Reversal, Caenorhabditis elegans"
xref: Reactome:REACT_99559 "ABH2 mediated Reversal of Alkylation Damage, Canis familiaris"
is_a: GO:0035510 ! DNA dealkylation
intersection_of: GO:0035510 ! DNA dealkylation
intersection_of: part_of GO:0006281 ! DNA repair
relationship: part_of GO:0006281 ! DNA repair

[Term]
id: GO:0006308
name: DNA catabolic process
namespace: biological_process
def: "The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "DNA breakdown" EXACT []
synonym: "DNA catabolism" EXACT []
synonym: "DNA degradation" EXACT []
is_a: GO:0006259 ! DNA metabolic process
is_a: GO:0034655 ! nucleobase-containing compound catabolic process
is_a: GO:0044265 ! cellular macromolecule catabolic process
relationship: has_part GO:0004536 ! deoxyribonuclease activity

[Term]
id: GO:0006309
name: apoptotic DNA fragmentation
namespace: biological_process
alt_id: GO:0008178
def: "The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, ISBN:0721639976, PMID:15723341, PMID:23379520]
comment: DNA fragmentation in response to apoptotic signals is achieved through the activity of apoptotic nucleases. In human, these include DNA fragmentation factor (DFF) or caspase-activated DNase (CAD) and endonuclease G (Endo G) (reviewed in PMID:15723341). Caution is needed when apoptotic DNA laddering assays show presence of fragmented DNA. A positive assay may simply reflect the end point of a whole apoptotic process. Unless clear experimental evidence is available to show that a gene product is directly involved in fragmenting DNA, please do not annotate to GO:0006309 'apoptotic DNA fragmentation' and consider annotating instead to a more upstream process such as, e.g., GO:0042981 'regulation of apoptotic process', GO:0006915 'apoptotic process', GO:0097190 'apoptotic signaling pathway'. Also, note that gene products involved in compartmentalization of apoptotic nucleases and in activation or repression of their enzymatic activity should be annotated to the regulation term GO:1902510 'regulation of apoptotic DNA fragmentation' or to one of its children (see PMID:15723341).
synonym: "chromatinolysis" BROAD [GOC:mtg_apoptosis]
synonym: "DNA catabolic process during apoptosis" EXACT []
synonym: "DNA catabolism during apoptosis" EXACT []
synonym: "DNA fragmentation" BROAD []
synonym: "DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:cjm, GOC:dph, GOC:tb]
synonym: "endonucleolytic DNA catabolic process involved in apoptosis" EXACT []
xref: Reactome:REACT_102783 "Apoptosis induced DNA fragmentation, Bos taurus"
xref: Reactome:REACT_105342 "Apoptosis induced DNA fragmentation, Sus scrofa"
xref: Reactome:REACT_110358 "Apoptosis induced DNA fragmentation, Xenopus tropicalis"
xref: Reactome:REACT_113418 "Apoptosis induced DNA fragmentation, Plasmodium falciparum"
xref: Reactome:REACT_1213 "Apoptosis induced DNA fragmentation, Homo sapiens"
xref: Reactome:REACT_28808 "Apoptosis induced DNA fragmentation, Rattus norvegicus"
xref: Reactome:REACT_33113 "Apoptosis induced DNA fragmentation, Mus musculus"
xref: Reactome:REACT_92967 "Apoptosis induced DNA fragmentation, Drosophila melanogaster"
xref: Reactome:REACT_94135 "Apoptosis induced DNA fragmentation, Taeniopygia guttata"
xref: Reactome:REACT_98713 "Apoptosis induced DNA fragmentation, Canis familiaris"
xref: Reactome:REACT_99275 "Apoptosis induced DNA fragmentation, Gallus gallus"
xref: Reactome:REACT_99925 "Apoptosis induced DNA fragmentation, Danio rerio"
is_a: GO:0000737 ! DNA catabolic process, endonucleolytic
intersection_of: GO:0000737 ! DNA catabolic process, endonucleolytic
intersection_of: part_of GO:0030262 ! apoptotic nuclear changes
relationship: part_of GO:0030262 ! apoptotic nuclear changes

[Term]
id: GO:0006310
name: DNA recombination
namespace: biological_process
def: "Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
is_a: GO:0006259 ! DNA metabolic process

[Term]
id: GO:0006311
name: meiotic gene conversion
namespace: biological_process
def: "The cell cycle process in which genetic information is transferred from one helix to another. It often occurs in association with general genetic recombination events, and is believed to be a straightforward consequence of the mechanisms of general recombination and DNA repair. For example, meiosis might yield three copies of the maternal version of an allele and only one copy of the paternal allele, indicating that one of the two copies of the paternal allele has been changed to a copy of the maternal allele." [ISBN:0815316194]
synonym: "gene conversion without reciprocal crossover" EXACT []
is_a: GO:0035822 ! gene conversion
is_a: GO:0044710 ! single-organism metabolic process
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0007127 ! meiosis I

[Term]
id: GO:0006312
name: mitotic recombination
namespace: biological_process
def: "The exchange, reciprocal or nonreciprocal, of genetic material between one DNA molecule and a homologous region of DNA that occurs during mitotic cell cycles." [GOC:elh]
xref: Wikipedia:Mitotic_crossover
is_a: GO:0006310 ! DNA recombination

[Term]
id: GO:0006313
name: transposition, DNA-mediated
namespace: biological_process
alt_id: GO:0006317
alt_id: GO:0006318
def: "Any process involved in a type of transpositional recombination which occurs via a DNA intermediate." [GOC:jp, ISBN:0198506732, ISBN:1555812090]
subset: gosubset_prok
synonym: "Class II transposition" EXACT []
synonym: "DNA transposition" EXACT [GOC:dph]
synonym: "P-element excision" NARROW []
synonym: "P-element transposition" NARROW []
synonym: "Tc1/mariner transposition" NARROW []
synonym: "Tc3 transposition" NARROW []
is_a: GO:0006310 ! DNA recombination
is_a: GO:0032196 ! transposition
is_a: GO:0044710 ! single-organism metabolic process

[Term]
id: GO:0006314
name: intron homing
namespace: biological_process
def: "Lateral transfer of an intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron." [PMID:10487208]
subset: gosubset_prok
is_a: GO:0006310 ! DNA recombination

[Term]
id: GO:0006315
name: homing of group II introns
namespace: biological_process
def: "Lateral transfer of a group II intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron; group II introns are self-splicing introns with a conserved secondary structure." [GOC:mcc, ISBN:0716743663, PMID:10487208]
subset: gosubset_prok
is_a: GO:0006314 ! intron homing

[Term]
id: GO:0006316
name: movement of group I intron
namespace: biological_process
def: "Lateral transfer of a group I intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron; group I introns are self-splicing introns that use guanosine as a cofactor in the splicing reaction." [GOC:mcc, ISBN:0716743663, PMID:10487208]
subset: gosubset_prok
is_a: GO:0006314 ! intron homing

[Term]
id: GO:0006323
name: DNA packaging
namespace: biological_process
def: "Any process in which DNA and associated proteins are formed into a compact, orderly structure." [GOC:mah, ISBN:0815316194]
subset: goslim_pir
synonym: "DNA condensation" EXACT []
synonym: "DNA organisation" EXACT [GOC:curators]
synonym: "DNA organization" EXACT [GOC:curators]
is_a: GO:0071103 ! DNA conformation change
relationship: has_part GO:0008301 ! DNA binding, bending

[Term]
id: GO:0006324
name: obsolete S phase-specific histone modification
namespace: biological_process
def: "OBSOLETE. The covalent alteration of one or more amino acid residues within a histone protein that takes place during, and results in a modification pattern characteristic of, S phase of the cell cycle." [GOC:mah, PMID:9990026]
comment: This term was made obsolete because histone modification already exists and the phase specificity is better captured as an annotation extension.
synonym: "S phase-specific histone modification" EXACT []
synonym: "S-phase-specific histone modification" EXACT []
is_obsolete: true
consider: GO:0016570

[Term]
id: GO:0006325
name: chromatin organization
namespace: biological_process
def: "Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin." [GOC:mah]
subset: goslim_pombe
subset: goslim_yeast
synonym: "chromatin organisation" EXACT [GOC:mah]
synonym: "establishment or maintenance of chromatin architecture" EXACT [GOC:mah]
is_a: GO:0043933 ! macromolecular complex subunit organization
relationship: part_of GO:0051276 ! chromosome organization

[Term]
id: GO:0006326
name: obsolete bent DNA binding
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a molecular function and not a biological process.
synonym: "bent DNA binding" EXACT []
is_obsolete: true
replaced_by: GO:0003681

[Term]
id: GO:0006327
name: obsolete random coil binding
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a molecular function and not a biological process.
synonym: "random coil binding" EXACT []
is_obsolete: true
consider: GO:0003695

[Term]
id: GO:0006328
name: obsolete AT binding
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a molecular function and not a biological process.
synonym: "AT binding" EXACT []
is_obsolete: true
replaced_by: GO:0003680

[Term]
id: GO:0006329
name: obsolete satellite DNA binding
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a molecular function and not a biological process.
synonym: "satellite DNA binding" EXACT []
is_obsolete: true
replaced_by: GO:0003696

[Term]
id: GO:0006330
name: obsolete single-stranded DNA binding
namespace: biological_process
alt_id: GO:0006331
alt_id: GO:0006332
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a molecular function and not a biological process.
synonym: "single-stranded DNA binding" EXACT []
is_obsolete: true
replaced_by: GO:0003697

[Term]
id: GO:0006333
name: chromatin assembly or disassembly
namespace: biological_process
def: "The formation or destruction of chromatin structures." [GOC:mah]
synonym: "chromatin assembly/disassembly" EXACT []
is_a: GO:0006325 ! chromatin organization

[Term]
id: GO:0006334
name: nucleosome assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]
synonym: "histone chaperone" RELATED [GOC:vw]
synonym: "nucleosome modeling" EXACT []
xref: Reactome:REACT_22344 "Nucleosome assembly, Homo sapiens"
is_a: GO:0006461 ! protein complex assembly
is_a: GO:0034728 ! nucleosome organization
is_a: GO:0065004 ! protein-DNA complex assembly
relationship: part_of GO:0031497 ! chromatin assembly

[Term]
id: GO:0006335
name: DNA replication-dependent nucleosome assembly
namespace: biological_process
def: "The formation of nucleosomes on newly replicated DNA, coupled to strand elongation." [GOC:mah]
is_a: GO:0006334 ! nucleosome assembly
is_a: GO:0034723 ! DNA replication-dependent nucleosome organization

[Term]
id: GO:0006336
name: DNA replication-independent nucleosome assembly
namespace: biological_process
def: "The formation of nucleosomes outside the context of DNA replication." [GOC:mah]
synonym: "transcription-coupled nucleosome assembly" EXACT []
is_a: GO:0006334 ! nucleosome assembly
is_a: GO:0034724 ! DNA replication-independent nucleosome organization

[Term]
id: GO:0006337
name: nucleosome disassembly
namespace: biological_process
def: "The controlled breakdown of nucleosomes, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]
is_a: GO:0032986 ! protein-DNA complex disassembly
is_a: GO:0034728 ! nucleosome organization
is_a: GO:0043241 ! protein complex disassembly
is_a: GO:1902589 ! single-organism organelle organization
relationship: part_of GO:0031498 ! chromatin disassembly

[Term]
id: GO:0006338
name: chromatin remodeling
namespace: biological_process
def: "Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation." [GOC:jid, PMID:12697820]
synonym: "chromatin modeling" EXACT []
synonym: "chromatin modelling" EXACT []
synonym: "chromatin remodelling" EXACT []
is_a: GO:0016568 ! chromatin modification

[Term]
id: GO:0006339
name: obsolete positive regulation of transcription of homeotic gene (trithorax group)
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription of homeotic genes of the trithorax group." [GOC:go_curators]
comment: This term was made obsolete because it relates to a specific gene family rather than a process.
synonym: "positive regulation of transcription of homeotic gene (trithorax group)" EXACT []
is_obsolete: true
consider: GO:0006342
consider: GO:0048096

[Term]
id: GO:0006340
name: obsolete negative regulation of transcription of homeotic gene (Polycomb group)
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription of homeotic genes of the Polycomb group." [GOC:go_curators]
comment: This term was made obsolete because it relates to a specific gene family rather than a process.
synonym: "negative regulation of transcription of homeotic gene (Polycomb group)" EXACT []
is_obsolete: true
consider: GO:0006342
consider: GO:0048096

[Term]
id: GO:0006341
name: obsolete chromatin insulator sequence binding
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a molecular function and not a biological process.
synonym: "chromatin insulator sequence binding" EXACT []
is_obsolete: true
replaced_by: GO:0043035

[Term]
id: GO:0006342
name: chromatin silencing
namespace: biological_process
alt_id: GO:0016440
def: "Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin." [GOC:mah, PMID:10219245]
comment: Note that this process is the opposite of chromatin-mediated maintenance of transcription. This regulation is exemplified by members of the Polycomb group, which maintain the inactive state of homeotic gene transcription.
synonym: "chromatin-mediated maintenance of transcriptional inactivation" EXACT []
synonym: "chromatin-mediated silencing" EXACT []
synonym: "heterochromatic silencing" RELATED []
synonym: "TGS" EXACT []
synonym: "transcriptional gene silencing" EXACT []
is_a: GO:0006325 ! chromatin organization
is_a: GO:0016458 ! gene silencing
is_a: GO:0045814 ! negative regulation of gene expression, epigenetic
is_a: GO:0045892 ! negative regulation of transcription, DNA-templated
relationship: negatively_regulates GO:0006351 ! transcription, DNA-templated

[Term]
id: GO:0006343
name: establishment of chromatin silencing
namespace: biological_process
def: "The initial formation of a transcriptionally silent chromatin structure such as heterochromatin." [GOC:mah]
synonym: "establishment of heterochromatic silencing" RELATED []
is_a: GO:0051276 ! chromosome organization
relationship: part_of GO:0006342 ! chromatin silencing

[Term]
id: GO:0006344
name: maintenance of chromatin silencing
namespace: biological_process
def: "The maintenance of chromatin in a transcriptionally silent state such as heterochromatin." [GOC:mah]
synonym: "maintenance of heterochromatic silencing" RELATED []
is_a: GO:0051276 ! chromosome organization
relationship: part_of GO:0006342 ! chromatin silencing

[Term]
id: GO:0006346
name: methylation-dependent chromatin silencing
namespace: biological_process
def: "Repression of transcription by methylation of DNA, leading to the formation of heterochromatin." [GOC:mah]
synonym: "methylation-dependent heterochromatic silencing" EXACT []
is_a: GO:0006342 ! chromatin silencing
is_a: GO:0016569 ! covalent chromatin modification
is_a: GO:1902589 ! single-organism organelle organization
intersection_of: GO:0006342 ! chromatin silencing
intersection_of: has_part GO:0006306 ! DNA methylation
relationship: has_part GO:0006306 ! DNA methylation

[Term]
id: GO:0006348
name: chromatin silencing at telomere
namespace: biological_process
def: "Repression of transcription of telomeric DNA by altering the structure of chromatin." [PMID:10219245]
synonym: "heterochromatic silencing at telomere" EXACT []
synonym: "telomere chromatin silencing" EXACT [GOC:mah]
synonym: "telomeric silencing" EXACT [GOC:bf]
is_a: GO:0006342 ! chromatin silencing
intersection_of: GO:0006342 ! chromatin silencing
intersection_of: occurs_in GO:0000781 ! chromosome, telomeric region
relationship: occurs_in GO:0000781 ! chromosome, telomeric region

[Term]
id: GO:0006349
name: regulation of gene expression by genetic imprinting
namespace: biological_process
def: "Heritable alterations in the activity of a gene that depend on whether it passed through the paternal or the maternal germline, but that are not encoded by DNA itself." [GOC:ems, ISBN:0198506732, PMID:11498578]
synonym: "regulation of gene expression by DNA imprinting" EXACT [GOC:mah]
xref: Wikipedia:Genomic_imprinting
is_a: GO:0040029 ! regulation of gene expression, epigenetic
is_a: GO:0071514 ! genetic imprinting
intersection_of: GO:0071514 ! genetic imprinting
intersection_of: regulates GO:0010467 ! gene expression
relationship: regulates GO:0010467 ! gene expression

[Term]
id: GO:0006351
name: transcription, DNA-templated
namespace: biological_process
alt_id: GO:0006350
alt_id: GO:0061018
alt_id: GO:0061022
def: "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
subset: goslim_aspergillus
subset: goslim_metagenomics
subset: goslim_pombe
subset: gosubset_prok
synonym: "cellular transcription" BROAD []
synonym: "cellular transcription, DNA-dependent" EXACT []
synonym: "DNA-dependent transcription" EXACT []
synonym: "transcription" BROAD []
synonym: "transcription regulator activity" RELATED []
synonym: "transcription, DNA-dependent" EXACT [GOC:txnOH]
xref: Wikipedia:Transcription_(genetics)
is_a: GO:0034645 ! cellular macromolecule biosynthetic process
is_a: GO:0097659 ! nucleic acid-templated transcription
relationship: part_of GO:0010467 ! gene expression

[Term]
id: GO:0006352
name: DNA-templated transcription, initiation
namespace: biological_process
def: "Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription." [GOC:jid, GOC:txnOH, PMID:18280161]
comment: Note that promoter clearance is represented as a separate step, not part_of either initiation or elongation.
subset: goslim_yeast
subset: gosubset_prok
synonym: "DNA-dependent RNA polymerase complex assembly at promoter" EXACT []
synonym: "DNA-dependent transcription, initiation" EXACT [GOC:txnOH]
synonym: "initiation of DNA-dependent transcription" EXACT [GOC:jh2]
synonym: "initiation of transcription, DNA-dependent" EXACT [GOC:mah]
synonym: "transcription initiation factor activity" RELATED []
synonym: "transcription initiation, DNA-dependent" RELATED [GOC:jh2]
is_a: GO:0032774 ! RNA biosynthetic process
relationship: part_of GO:0006351 ! transcription, DNA-templated

[Term]
id: GO:0006353
name: DNA-templated transcription, termination
namespace: biological_process
def: "The cellular process that completes DNA-templated transcription; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA." [GOC:txnOH, ISBN:0716720094, PMID:15020047, PMID:18280161]
subset: goslim_yeast
subset: gosubset_prok
synonym: "DNA-dependent transcription, termination" EXACT [GOC:txnOH]
synonym: "termination of DNA-dependent transcription" EXACT [GOC:jh2]
synonym: "termination of transcription, DNA-dependent" EXACT [GOC:mah]
synonym: "transcription termination factor activity" RELATED []
synonym: "transcription termination, DNA-dependent" RELATED [GOC:jh2]
synonym: "transcriptional complex disassembly" BROAD []
is_a: GO:0032774 ! RNA biosynthetic process
relationship: part_of GO:0006351 ! transcription, DNA-templated

[Term]
id: GO:0006354
name: DNA-templated transcription, elongation
namespace: biological_process
def: "The extension of an RNA molecule after transcription initiation and promoter clearance at a DNA-dependent RNA polymerase promoter by the addition of ribonucleotides catalyzed by an RNA polymerase." [GOC:mah, GOC:txnOH, PMID:15020047, PMID:18280161]
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
synonym: "DNA-dependent transcription, elongation" EXACT [GOC:txnOH]
synonym: "RNA elongation" BROAD []
synonym: "transcription elongation, DNA-dependent" EXACT [GOC:jh2]
synonym: "transcriptional elongation, DNA-dependent" EXACT []
is_a: GO:0032774 ! RNA biosynthetic process
relationship: part_of GO:0006351 ! transcription, DNA-templated

[Term]
id: GO:0006355
name: regulation of transcription, DNA-templated
namespace: biological_process
alt_id: GO:0032583
alt_id: GO:0045449
alt_id: GO:0061019
def: "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
subset: goslim_pombe
subset: gosubset_prok
synonym: "regulation of cellular transcription, DNA-dependent" EXACT []
synonym: "regulation of gene-specific transcription" RELATED []
synonym: "regulation of transcription, DNA-dependent" EXACT [GOC:txnOH]
synonym: "transcriptional control" BROAD []
is_a: GO:0010468 ! regulation of gene expression
is_a: GO:1903506 ! regulation of nucleic acid-templated transcription
is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006351 ! transcription, DNA-templated
relationship: regulates GO:0006351 ! transcription, DNA-templated

[Term]
id: GO:0006356
name: regulation of transcription from RNA polymerase I promoter
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase I promoter." [GOC:go_curators]
synonym: "regulation of transcription from Pol I promoter" EXACT []
is_a: GO:0006355 ! regulation of transcription, DNA-templated
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006360 ! transcription from RNA polymerase I promoter
relationship: regulates GO:0006360 ! transcription from RNA polymerase I promoter

[Term]
id: GO:0006357
name: regulation of transcription from RNA polymerase II promoter
namespace: biological_process
alt_id: GO:0006358
alt_id: GO:0010551
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
synonym: "global transcription regulation from Pol II promoter" RELATED []
synonym: "regulation of gene-specific transcription from RNA polymerase II promoter" RELATED []
synonym: "regulation of global transcription from Pol II promoter" RELATED []
synonym: "regulation of transcription from Pol II promoter" EXACT []
synonym: "regulation of transcription from RNA polymerase II promoter, global" RELATED []
is_a: GO:0006355 ! regulation of transcription, DNA-templated
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006366 ! transcription from RNA polymerase II promoter
relationship: regulates GO:0006366 ! transcription from RNA polymerase II promoter

[Term]
id: GO:0006359
name: regulation of transcription from RNA polymerase III promoter
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA ploymerase III promoter." [GOC:go_curators]
synonym: "regulation of transcription from Pol III promoter" EXACT []
is_a: GO:0006355 ! regulation of transcription, DNA-templated
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006383 ! transcription from RNA polymerase III promoter
relationship: regulates GO:0006383 ! transcription from RNA polymerase III promoter

[Term]
id: GO:0006360
name: transcription from RNA polymerase I promoter
namespace: biological_process
def: "The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter." [GOC:jl, GOC:txnOH]
subset: goslim_yeast
synonym: "RNA polymerase I transcription factor activity" RELATED []
synonym: "transcription from Pol I promoter" EXACT []
xref: Reactome:REACT_100735 "RNA Polymerase I Transcription, Mus musculus"
xref: Reactome:REACT_100886 "RNA Polymerase I Transcription, Xenopus tropicalis"
xref: Reactome:REACT_110611 "RNA Polymerase I Transcription, Saccharomyces cerevisiae"
xref: Reactome:REACT_110625 "RNA Polymerase I Transcription, Drosophila melanogaster"
xref: Reactome:REACT_1309 "RNA Polymerase I Transcription, Homo sapiens"
xref: Reactome:REACT_28615 "RNA Polymerase I Transcription, Taeniopygia guttata"
xref: Reactome:REACT_28661 "RNA Polymerase I Transcription, Canis familiaris"
xref: Reactome:REACT_30029 "RNA Polymerase I Transcription, Caenorhabditis elegans"
xref: Reactome:REACT_31383 "RNA Polymerase I Transcription, Gallus gallus"
xref: Reactome:REACT_32101 "RNA Polymerase I Transcription, Bos taurus"
xref: Reactome:REACT_39475 "RNA Polymerase I Transcription, Rattus norvegicus"
xref: Reactome:REACT_77153 "RNA Polymerase I Transcription, Sus scrofa"
xref: Reactome:REACT_78975 "RNA Polymerase I Transcription, Danio rerio"
xref: Reactome:REACT_84230 "RNA Polymerase I Transcription, Oryza sativa"
xref: Reactome:REACT_92088 "RNA Polymerase I Transcription, Dictyostelium discoideum"
xref: Reactome:REACT_95034 "RNA Polymerase I Transcription, Schizosaccharomyces pombe"
xref: Reactome:REACT_95463 "RNA Polymerase I Transcription, Arabidopsis thaliana"
is_a: GO:0006351 ! transcription, DNA-templated

[Term]
id: GO:0006361
name: transcription initiation from RNA polymerase I promoter
namespace: biological_process
def: "Any process involved in the assembly of the RNA polymerase I preinitiation complex (PIC) at an RNA polymerase I promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH]
comment: Note that promoter clearance is represented as a separate step, not part_of either initiation or elongation.
synonym: "transcription initiation from Pol I promoter" EXACT []
xref: Reactome:REACT_102820 "RNA Polymerase I Promoter Escape, Danio rerio"
xref: Reactome:REACT_103321 "RNA Polymerase I Promoter Opening, Xenopus tropicalis"
xref: Reactome:REACT_104294 "RNA Polymerase I Promoter Clearance, Gallus gallus"
xref: Reactome:REACT_104732 "RNA Polymerase I Transcription Initiation, Arabidopsis thaliana"
xref: Reactome:REACT_107761 "RNA Polymerase I Promoter Opening, Bos taurus"
xref: Reactome:REACT_108121 "RNA Polymerase I Promoter Clearance, Xenopus tropicalis"
xref: Reactome:REACT_108556 "RNA Polymerase I Promoter Clearance, Dictyostelium discoideum"
xref: Reactome:REACT_109608 "RNA Polymerase I Promoter Clearance, Danio rerio"
xref: Reactome:REACT_109713 "RNA Polymerase I Promoter Opening, Canis familiaris"
xref: Reactome:REACT_109923 "RNA Polymerase I Transcription Initiation, Bos taurus"
xref: Reactome:REACT_110381 "RNA Polymerase I Promoter Clearance, Mus musculus"
xref: Reactome:REACT_112001 "RNA Polymerase I Promoter Escape, Oryza sativa"
xref: Reactome:REACT_112095 "RNA Polymerase I Promoter Opening, Rattus norvegicus"
xref: Reactome:REACT_113247 "RNA Polymerase I Promoter Escape, Gallus gallus"
xref: Reactome:REACT_114933 "RNA Polymerase I Promoter Escape, Rattus norvegicus"
xref: Reactome:REACT_1913 "RNA Polymerase I Promoter Escape, Homo sapiens"
xref: Reactome:REACT_1974 "RNA Polymerase I Promoter Clearance, Homo sapiens"
xref: Reactome:REACT_2232 "RNA Polymerase I Promoter Opening, Homo sapiens"
xref: Reactome:REACT_28247 "RNA Polymerase I Transcription Initiation, Sus scrofa"
xref: Reactome:REACT_28672 "RNA Polymerase I Promoter Clearance, Sus scrofa"
xref: Reactome:REACT_29421 "RNA Polymerase I Promoter Escape, Taeniopygia guttata"
xref: Reactome:REACT_32043 "RNA Polymerase I Promoter Clearance, Oryza sativa"
xref: Reactome:REACT_32220 "RNA Polymerase I Promoter Clearance, Canis familiaris"
xref: Reactome:REACT_32256 "RNA Polymerase I Transcription Initiation, Taeniopygia guttata"
xref: Reactome:REACT_32967 "RNA Polymerase I Promoter Clearance, Arabidopsis thaliana"
xref: Reactome:REACT_33565 "RNA Polymerase I Promoter Opening, Danio rerio"
xref: Reactome:REACT_52895 "RNA Polymerase I Promoter Clearance, Caenorhabditis elegans"
xref: Reactome:REACT_70483 "RNA Polymerase I Transcription Initiation, Mus musculus"
xref: Reactome:REACT_78359 "RNA Polymerase I Promoter Escape, Caenorhabditis elegans"
xref: Reactome:REACT_78467 "RNA Polymerase I Transcription Initiation, Dictyostelium discoideum"
xref: Reactome:REACT_78822 "RNA Polymerase I Transcription Initiation, Drosophila melanogaster"
xref: Reactome:REACT_80187 "RNA Polymerase I Transcription Initiation, Xenopus tropicalis"
xref: Reactome:REACT_80295 "RNA Polymerase I Promoter Opening, Sus scrofa"
xref: Reactome:REACT_80486 "RNA Polymerase I Promoter Clearance, Drosophila melanogaster"
xref: Reactome:REACT_82342 "RNA Polymerase I Promoter Clearance, Schizosaccharomyces pombe"
xref: Reactome:REACT_82716 "RNA Polymerase I Transcription Initiation, Caenorhabditis elegans"
xref: Reactome:REACT_84081 "RNA Polymerase I Transcription Initiation, Schizosaccharomyces pombe"
xref: Reactome:REACT_85798 "RNA Polymerase I Transcription Initiation, Canis familiaris"
xref: Reactome:REACT_86090 "RNA Polymerase I Promoter Opening, Mus musculus"
xref: Reactome:REACT_86119 "RNA Polymerase I Promoter Opening, Taeniopygia guttata"
xref: Reactome:REACT_86887 "RNA Polymerase I Transcription Initiation, Oryza sativa"
xref: Reactome:REACT_88016 "RNA Polymerase I Promoter Clearance, Rattus norvegicus"
xref: Reactome:REACT_88842 "RNA Polymerase I Transcription Initiation, Saccharomyces cerevisiae"
xref: Reactome:REACT_89345 "RNA Polymerase I Promoter Clearance, Saccharomyces cerevisiae"
xref: Reactome:REACT_89969 "RNA Polymerase I Transcription Initiation, Rattus norvegicus"
xref: Reactome:REACT_90628 "RNA Polymerase I Transcription Initiation, Danio rerio"
xref: Reactome:REACT_90876 "RNA Polymerase I Transcription Initiation, Gallus gallus"
xref: Reactome:REACT_91155 "RNA Polymerase I Promoter Escape, Mus musculus"
xref: Reactome:REACT_92356 "RNA Polymerase I Promoter Clearance, Bos taurus"
xref: Reactome:REACT_94173 "RNA Polymerase I Promoter Escape, Drosophila melanogaster"
xref: Reactome:REACT_953 "RNA Polymerase I Transcription Initiation, Homo sapiens"
xref: Reactome:REACT_97336 "RNA Polymerase I Promoter Escape, Schizosaccharomyces pombe"
xref: Reactome:REACT_97424 "RNA Polymerase I Promoter Clearance, Taeniopygia guttata"
xref: Reactome:REACT_97947 "RNA Polymerase I Promoter Escape, Xenopus tropicalis"
is_a: GO:0006352 ! DNA-templated transcription, initiation
relationship: part_of GO:0006360 ! transcription from RNA polymerase I promoter

[Term]
id: GO:0006362
name: transcription elongation from RNA polymerase I promoter
namespace: biological_process
def: "The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase I specific promoter by the addition of ribonucleotides catalyzed by RNA polymerase I." [GOC:mah, GOC:txnOH]
synonym: "RNA elongation from Pol I promoter" EXACT []
synonym: "RNA polymerase I transcription elongation factor activity" RELATED []
xref: Reactome:REACT_100733 "RNA Polymerase I Chain Elongation, Caenorhabditis elegans"
xref: Reactome:REACT_105916 "RNA Polymerase I Chain Elongation, Canis familiaris"
xref: Reactome:REACT_112721 "RNA Polymerase I Chain Elongation, Oryza sativa"
xref: Reactome:REACT_115044 "RNA Polymerase I Chain Elongation, Gallus gallus"
xref: Reactome:REACT_2204 "RNA Polymerase I Chain Elongation, Homo sapiens"
xref: Reactome:REACT_28877 "RNA Polymerase I Chain Elongation, Schizosaccharomyces pombe"
xref: Reactome:REACT_79758 "RNA Polymerase I Chain Elongation, Xenopus tropicalis"
xref: Reactome:REACT_80680 "RNA Polymerase I Chain Elongation, Taeniopygia guttata"
xref: Reactome:REACT_81860 "RNA Polymerase I Chain Elongation, Rattus norvegicus"
xref: Reactome:REACT_85058 "RNA Polymerase I Chain Elongation, Mus musculus"
xref: Reactome:REACT_86256 "RNA Polymerase I Chain Elongation, Drosophila melanogaster"
xref: Reactome:REACT_88778 "RNA Polymerase I Chain Elongation, Danio rerio"
xref: Reactome:REACT_89996 "RNA Polymerase I Chain Elongation, Sus scrofa"
xref: Reactome:REACT_90748 "RNA Polymerase I Chain Elongation, Bos taurus"
is_a: GO:0006354 ! DNA-templated transcription, elongation
relationship: part_of GO:0006360 ! transcription from RNA polymerase I promoter

[Term]
id: GO:0006363
name: termination of RNA polymerase I transcription
namespace: biological_process
alt_id: GO:0019223
def: "The process in which the synthesis of an RNA molecule by RNA polymerase I using a DNA template is completed. RNAP I termination requires binding of a terminator protein so specific sequences downstream of the transcription unit." [GOC:mah, GOC:txnOH, PMID:10684922]
synonym: "RNA polymerase I transcription termination" EXACT []
synonym: "RNA polymerase I transcription termination factor activity" RELATED []
synonym: "transcription termination from Pol I promoter" EXACT []
synonym: "transcription termination from RNA polymerase I promoter" EXACT []
xref: Reactome:REACT_101118 "RNA Polymerase I Transcription Termination, Danio rerio"
xref: Reactome:REACT_104744 "RNA Polymerase I Transcription Termination, Canis familiaris"
xref: Reactome:REACT_1074 "RNA Polymerase I Transcription Termination, Homo sapiens"
xref: Reactome:REACT_113509 "RNA Polymerase I Transcription Termination, Gallus gallus"
xref: Reactome:REACT_32721 "RNA Polymerase I Transcription Termination, Taeniopygia guttata"
xref: Reactome:REACT_78534 "RNA Polymerase I Transcription Termination, Mus musculus"
xref: Reactome:REACT_80987 "RNA Polymerase I Transcription Termination, Bos taurus"
xref: Reactome:REACT_86818 "RNA Polymerase I Transcription Termination, Oryza sativa"
xref: Reactome:REACT_87748 "RNA Polymerase I Transcription Termination, Arabidopsis thaliana"
xref: Reactome:REACT_89655 "RNA Polymerase I Transcription Termination, Rattus norvegicus"
xref: Reactome:REACT_89930 "RNA Polymerase I Transcription Termination, Sus scrofa"
xref: Reactome:REACT_98009 "RNA Polymerase I Transcription Termination, Xenopus tropicalis"
is_a: GO:0006353 ! DNA-templated transcription, termination
relationship: part_of GO:0006360 ! transcription from RNA polymerase I promoter

[Term]
id: GO:0006364
name: rRNA processing
namespace: biological_process
alt_id: GO:0006365
def: "Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]
subset: goslim_yeast
subset: gosubset_prok
synonym: "35S primary transcript processing" NARROW []
is_a: GO:0016072 ! rRNA metabolic process
is_a: GO:0034470 ! ncRNA processing
relationship: part_of GO:0042254 ! ribosome biogenesis

[Term]
id: GO:0006366
name: transcription from RNA polymerase II promoter
namespace: biological_process
alt_id: GO:0032568
alt_id: GO:0032569
def: "The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
subset: goslim_yeast
synonym: "gene-specific transcription from RNA polymerase II promoter" RELATED []
synonym: "general transcription from RNA polymerase II promoter" RELATED []
synonym: "RNA polymerase II transcription factor activity" RELATED []
synonym: "specific transcription from RNA polymerase II promoter" RELATED [GOC:mah]
synonym: "transcription from Pol II promoter" EXACT []
xref: Reactome:REACT_105738 "RNA Polymerase II Transcription, Bos taurus"
xref: Reactome:REACT_106213 "RNA Polymerase II Transcription, Caenorhabditis elegans"
xref: Reactome:REACT_108012 "RNA Polymerase II Transcription, Canis familiaris"
xref: Reactome:REACT_109421 "RNA Polymerase II Transcription, Xenopus tropicalis"
xref: Reactome:REACT_1366 "RNA Polymerase II Transcription, Homo sapiens"
xref: Reactome:REACT_31558 "RNA Polymerase II Transcription, Taeniopygia guttata"
xref: Reactome:REACT_32943 "RNA Polymerase II Transcription, Danio rerio"
xref: Reactome:REACT_33538 "RNA Polymerase II Transcription, Rattus norvegicus"
xref: Reactome:REACT_33583 "RNA Polymerase II Transcription, Sus scrofa"
xref: Reactome:REACT_34720 "RNA Polymerase II Transcription, Schizosaccharomyces pombe"
xref: Reactome:REACT_79747 "RNA Polymerase II Transcription, Plasmodium falciparum"
xref: Reactome:REACT_89454 "RNA Polymerase II Transcription, Oryza sativa"
xref: Reactome:REACT_89916 "RNA Polymerase II Transcription, Mus musculus"
xref: Reactome:REACT_97471 "RNA Polymerase II Transcription, Arabidopsis thaliana"
xref: Reactome:REACT_97536 "RNA Polymerase II Transcription, Gallus gallus"
xref: Reactome:REACT_99228 "RNA Polymerase II Transcription, Drosophila melanogaster"
xref: Reactome:REACT_99748 "RNA Polymerase II Transcription, Dictyostelium discoideum"
xref: Reactome:REACT_99950 "RNA Polymerase II Transcription, Saccharomyces cerevisiae"
is_a: GO:0006351 ! transcription, DNA-templated

[Term]
id: GO:0006367
name: transcription initiation from RNA polymerase II promoter
namespace: biological_process
def: "Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH]
comment: Note that promoter clearance is represented as a separate step, not part_of either initiation or elongation.
synonym: "transcription initiation from Pol II promoter" EXACT []
xref: Reactome:REACT_100392 "RNA Polymerase II Transcription Initiation, Dictyostelium discoideum"
xref: Reactome:REACT_101175 "RNA Polymerase II Transcription Initiation, Canis familiaris"
xref: Reactome:REACT_101341 "RNA Polymerase II Transcription Initiation, Danio rerio"
xref: Reactome:REACT_102266 "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, Canis familiaris"
xref: Reactome:REACT_103457 "RNA Polymerase II Transcription Initiation, Mus musculus"
xref: Reactome:REACT_104036 "RNA Polymerase II Transcription Initiation, Drosophila melanogaster"
xref: Reactome:REACT_104646 "RNA Polymerase II Transcription Initiation, Caenorhabditis elegans"
xref: Reactome:REACT_104707 "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, Danio rerio"
xref: Reactome:REACT_105389 "RNA Polymerase II Transcription Initiation, Oryza sativa"
xref: Reactome:REACT_1655 "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, Homo sapiens"
xref: Reactome:REACT_1851 "RNA Polymerase II Transcription Initiation, Homo sapiens"
xref: Reactome:REACT_28862 "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, Oryza sativa"
xref: Reactome:REACT_31702 "RNA Polymerase II Transcription Initiation, Gallus gallus"
xref: Reactome:REACT_32920 "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, Bos taurus"
xref: Reactome:REACT_6332 "HIV-1 Transcription Initiation, Homo sapiens"
xref: Reactome:REACT_77736 "RNA Polymerase II Transcription Initiation, Xenopus tropicalis"
xref: Reactome:REACT_79444 "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, Drosophila melanogaster"
xref: Reactome:REACT_79812 "RNA Polymerase II Transcription Initiation, Rattus norvegicus"
xref: Reactome:REACT_80956 "RNA Polymerase II Transcription Initiation, Schizosaccharomyces pombe"
xref: Reactome:REACT_81703 "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, Dictyostelium discoideum"
xref: Reactome:REACT_82794 "RNA Polymerase II Transcription Initiation, Bos taurus"
xref: Reactome:REACT_83749 "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, Saccharomyces cerevisiae"
xref: Reactome:REACT_84134 "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, Mus musculus"
xref: Reactome:REACT_85783 "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, Schizosaccharomyces pombe"
xref: Reactome:REACT_85917 "RNA Polymerase II Transcription Initiation, Taeniopygia guttata"
xref: Reactome:REACT_85990 "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, Xenopus tropicalis"
xref: Reactome:REACT_87429 "RNA Polymerase II Transcription Initiation, Saccharomyces cerevisiae"
xref: Reactome:REACT_87559 "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, Caenorhabditis elegans"
xref: Reactome:REACT_88340 "RNA Polymerase II Transcription Initiation, Arabidopsis thaliana"
xref: Reactome:REACT_88353 "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, Gallus gallus"
xref: Reactome:REACT_92769 "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, Rattus norvegicus"
xref: Reactome:REACT_95808 "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, Taeniopygia guttata"
xref: Reactome:REACT_98915 "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, Arabidopsis thaliana"
is_a: GO:0006352 ! DNA-templated transcription, initiation
relationship: part_of GO:0006366 ! transcription from RNA polymerase II promoter

[Term]
id: GO:0006368
name: transcription elongation from RNA polymerase II promoter
namespace: biological_process
def: "The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH]
synonym: "RNA elongation from Pol II promoter" EXACT []
synonym: "RNA polymerase II transcription elongation factor activity" RELATED []
xref: Reactome:REACT_100066 "RNA Polymerase II Transcription Elongation, Rattus norvegicus"
xref: Reactome:REACT_100727 "Formation of the Early Elongation Complex, Gallus gallus"
xref: Reactome:REACT_101279 "Formation of the Early Elongation Complex, Caenorhabditis elegans"
xref: Reactome:REACT_101816 "Formation of the Early Elongation Complex, Schizosaccharomyces pombe"
xref: Reactome:REACT_104824 "RNA Polymerase II Promoter Escape, Xenopus tropicalis"
xref: Reactome:REACT_104937 "RNA Polymerase II Transcription Elongation, Mus musculus"
xref: Reactome:REACT_106139 "RNA Polymerase II Promoter Escape, Danio rerio"
xref: Reactome:REACT_106149 "RNA Polymerase II Promoter Escape, Oryza sativa"
xref: Reactome:REACT_107633 "RNA Polymerase II Transcription Elongation, Arabidopsis thaliana"
xref: Reactome:REACT_107789 "RNA Polymerase II Promoter Escape, Saccharomyces cerevisiae"
xref: Reactome:REACT_108831 "Formation of RNA Pol II elongation complex, Xenopus tropicalis"
xref: Reactome:REACT_109274 "RNA Polymerase II Promoter Escape, Caenorhabditis elegans"
xref: Reactome:REACT_109291 "Formation of the Early Elongation Complex, Mus musculus"
xref: Reactome:REACT_110182 "Formation of RNA Pol II elongation complex, Mus musculus"
xref: Reactome:REACT_110507 "RNA Polymerase II Transcription Elongation, Danio rerio"
xref: Reactome:REACT_112408 "Formation of RNA Pol II elongation complex, Drosophila melanogaster"
xref: Reactome:REACT_112630 "Formation of RNA Pol II elongation complex, Schizosaccharomyces pombe"
xref: Reactome:REACT_113325 "Formation of RNA Pol II elongation complex, Caenorhabditis elegans"
xref: Reactome:REACT_115524 "Formation of RNA Pol II elongation complex, Danio rerio"
xref: Reactome:REACT_1845 "Formation of RNA Pol II elongation complex, Homo sapiens"
xref: Reactome:REACT_2089 "RNA Polymerase II Promoter Escape, Homo sapiens"
xref: Reactome:REACT_28524 "Formation of RNA Pol II elongation complex, Bos taurus"
xref: Reactome:REACT_28692 "Formation of the Early Elongation Complex, Danio rerio"
xref: Reactome:REACT_28768 "RNA Polymerase II Transcription Elongation, Xenopus tropicalis"
xref: Reactome:REACT_29367 "RNA Polymerase II Transcription Elongation, Taeniopygia guttata"
xref: Reactome:REACT_29380 "Formation of the Early Elongation Complex, Arabidopsis thaliana"
xref: Reactome:REACT_31308 "Formation of the Early Elongation Complex, Rattus norvegicus"
xref: Reactome:REACT_31396 "RNA Polymerase II Promoter Escape, Mus musculus"
xref: Reactome:REACT_31533 "RNA Polymerase II Transcription Elongation, Canis familiaris"
xref: Reactome:REACT_32311 "RNA Polymerase II Transcription Elongation, Bos taurus"
xref: Reactome:REACT_32712 "Formation of RNA Pol II elongation complex, Canis familiaris"
xref: Reactome:REACT_32829 "RNA Polymerase II Promoter Escape, Arabidopsis thaliana"
xref: Reactome:REACT_55595 "RNA Polymerase II Promoter Escape, Schizosaccharomyces pombe"
xref: Reactome:REACT_6274 "HIV-1 Transcription Elongation, Homo sapiens"
xref: Reactome:REACT_66965 "RNA Polymerase II Promoter Escape, Dictyostelium discoideum"
xref: Reactome:REACT_77610 "RNA Polymerase II Promoter Escape, Bos taurus"
xref: Reactome:REACT_78366 "Formation of RNA Pol II elongation complex, Rattus norvegicus"
xref: Reactome:REACT_81662 "RNA Polymerase II Promoter Escape, Drosophila melanogaster"
xref: Reactome:REACT_81750 "RNA Polymerase II Transcription Elongation, Saccharomyces cerevisiae"
xref: Reactome:REACT_81845 "RNA Polymerase II Promoter Escape, Rattus norvegicus"
xref: Reactome:REACT_833 "RNA Polymerase II Transcription Elongation, Homo sapiens"
xref: Reactome:REACT_83871 "Formation of the Early Elongation Complex, Dictyostelium discoideum"
xref: Reactome:REACT_84247 "Formation of the Early Elongation Complex, Taeniopygia guttata"
xref: Reactome:REACT_84349 "Formation of the Early Elongation Complex, Oryza sativa"
xref: Reactome:REACT_846 "Formation of the Early Elongation Complex, Homo sapiens"
xref: Reactome:REACT_87946 "RNA Polymerase II Transcription Elongation, Caenorhabditis elegans"
xref: Reactome:REACT_89781 "RNA Polymerase II Transcription Elongation, Gallus gallus"
xref: Reactome:REACT_90242 "RNA Polymerase II Promoter Escape, Gallus gallus"
xref: Reactome:REACT_91644 "Formation of the Early Elongation Complex, Xenopus tropicalis"
xref: Reactome:REACT_92647 "Formation of the Early Elongation Complex, Canis familiaris"
xref: Reactome:REACT_92836 "RNA Polymerase II Transcription Elongation, Drosophila melanogaster"
xref: Reactome:REACT_93156 "Formation of the Early Elongation Complex, Bos taurus"
xref: Reactome:REACT_93741 "RNA Polymerase II Transcription Elongation, Schizosaccharomyces pombe"
xref: Reactome:REACT_94090 "RNA Polymerase II Transcription Elongation, Oryza sativa"
xref: Reactome:REACT_96685 "RNA Polymerase II Promoter Escape, Canis familiaris"
xref: Reactome:REACT_97522 "Formation of the Early Elongation Complex, Drosophila melanogaster"
xref: Reactome:REACT_99278 "RNA Polymerase II Transcription Elongation, Dictyostelium discoideum"
xref: Reactome:REACT_99528 "Formation of the Early Elongation Complex, Saccharomyces cerevisiae"
is_a: GO:0006354 ! DNA-templated transcription, elongation
relationship: part_of GO:0006366 ! transcription from RNA polymerase II promoter

[Term]
id: GO:0006369
name: termination of RNA polymerase II transcription
namespace: biological_process
alt_id: GO:0019224
def: "The process in which the synthesis of an RNA molecule by RNA polymerase II using a DNA template is completed." [GOC:mah, GOC:txnOH]
synonym: "RNA 3'-end formation by RNA polymerase II" EXACT []
synonym: "RNA polymerase II transcription termination" EXACT []
synonym: "RNA polymerase II transcription termination factor activity" RELATED []
synonym: "transcription termination from Pol II promoter" EXACT []
synonym: "transcription termination from RNA polymerase II promoter" EXACT []
xref: Reactome:REACT_102337 "Cleavage of Growing Transcript in the Termination Region, Bos taurus"
xref: Reactome:REACT_108223 "RNA Polymerase II Transcription Termination, Gallus gallus"
xref: Reactome:REACT_109258 "RNA Polymerase II Transcription Termination, Canis familiaris"
xref: Reactome:REACT_112978 "RNA Polymerase II Transcription Termination, Drosophila melanogaster"
xref: Reactome:REACT_113157 "RNA Polymerase II Transcription Termination, Arabidopsis thaliana"
xref: Reactome:REACT_113171 "Cleavage of Growing Transcript in the Termination Region, Drosophila melanogaster"
xref: Reactome:REACT_114593 "Cleavage of Growing Transcript in the Termination Region, Danio rerio"
xref: Reactome:REACT_114998 "RNA Polymerase II Transcription Termination, Danio rerio"
xref: Reactome:REACT_115466 "Cleavage of Growing Transcript in the Termination Region, Arabidopsis thaliana"
xref: Reactome:REACT_33376 "RNA Polymerase II Transcription Termination, Mus musculus"
xref: Reactome:REACT_33730 "Cleavage of Growing Transcript in the Termination Region, Caenorhabditis elegans"
xref: Reactome:REACT_34293 "Cleavage of Growing Transcript in the Termination Region, Rattus norvegicus"
xref: Reactome:REACT_387 "Cleavage of Growing Transcript in the Termination Region, Homo sapiens"
xref: Reactome:REACT_53836 "RNA Polymerase II Transcription Termination, Caenorhabditis elegans"
xref: Reactome:REACT_6241 "HIV-1 Transcription Termination, Human immunodeficiency virus 1"
xref: Reactome:REACT_86797 "RNA Polymerase II Transcription Termination, Xenopus tropicalis"
xref: Reactome:REACT_894 "RNA Polymerase II Transcription Termination, Homo sapiens"
xref: Reactome:REACT_89456 "Cleavage of Growing Transcript in the Termination Region, Taeniopygia guttata"
xref: Reactome:REACT_89598 "RNA Polymerase II Transcription Termination, Bos taurus"
xref: Reactome:REACT_92795 "Cleavage of Growing Transcript in the Termination Region, Mus musculus"
xref: Reactome:REACT_94319 "Cleavage of Growing Transcript in the Termination Region, Xenopus tropicalis"
xref: Reactome:REACT_95051 "RNA Polymerase II Transcription Termination, Taeniopygia guttata"
xref: Reactome:REACT_97415 "Cleavage of Growing Transcript in the Termination Region, Gallus gallus"
xref: Reactome:REACT_97704 "Cleavage of Growing Transcript in the Termination Region, Canis familiaris"
xref: Reactome:REACT_99283 "RNA Polymerase II Transcription Termination, Rattus norvegicus"
is_a: GO:0006353 ! DNA-templated transcription, termination
relationship: part_of GO:0006366 ! transcription from RNA polymerase II promoter

[Term]
id: GO:0006370
name: 7-methylguanosine mRNA capping
namespace: biological_process
def: "Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript." [GOC:mah, PMID:9266685]
synonym: "5' end capping" BROAD []
synonym: "5' mRNA capping" EXACT []
synonym: "5'-end mRNA processing" EXACT []
synonym: "5'-end processing" BROAD []
synonym: "mRNA capping" EXACT [GOC:bf, GOC:krc, GOC:mah]
xref: Reactome:REACT_101832 "mRNA Capping, Canis familiaris"
xref: Reactome:REACT_102770 "mRNA Capping, Saccharomyces cerevisiae"
xref: Reactome:REACT_110937 "mRNA Capping, Xenopus tropicalis"
xref: Reactome:REACT_114999 "mRNA Capping, Plasmodium falciparum"
xref: Reactome:REACT_1470 "mRNA Capping, Homo sapiens"
xref: Reactome:REACT_31827 "mRNA Capping, Mus musculus"
xref: Reactome:REACT_79473 "mRNA Capping, Taeniopygia guttata"
xref: Reactome:REACT_81603 "mRNA Capping, Oryza sativa"
xref: Reactome:REACT_84705 "mRNA Capping, Bos taurus"
xref: Reactome:REACT_85081 "mRNA Capping, Drosophila melanogaster"
xref: Reactome:REACT_85562 "mRNA Capping, Caenorhabditis elegans"
xref: Reactome:REACT_85971 "mRNA Capping, Gallus gallus"
xref: Reactome:REACT_86299 "mRNA Capping, Rattus norvegicus"
xref: Reactome:REACT_87055 "mRNA Capping, Danio rerio"
xref: Reactome:REACT_89815 "mRNA Capping, Schizosaccharomyces pombe"
xref: Reactome:REACT_93735 "mRNA Capping, Arabidopsis thaliana"
xref: Reactome:REACT_95432 "mRNA Capping, Sus scrofa"
xref: Reactome:REACT_96579 "mRNA Capping, Dictyostelium discoideum"
is_a: GO:0006397 ! mRNA processing
is_a: GO:0009452 ! 7-methylguanosine RNA capping

[Term]
id: GO:0006371
name: obsolete mRNA splicing
namespace: biological_process
def: "OBSOLETE. The process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732]
comment: This term was made obsolete because it represents several different processes.
synonym: "mRNA splicing" EXACT []
is_obsolete: true
consider: GO:0000372
consider: GO:0000373
consider: GO:0000374
consider: GO:0000394
consider: GO:0000398

[Term]
id: GO:0006372
name: obsolete lariat formation, 5'-splice site cleavage
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:krc]
comment: This term was made obsolete because it represents a molecular function.
synonym: "lariat formation, 5'-splice site cleavage" EXACT []
is_obsolete: true
consider: GO:0000350
consider: GO:0000386

[Term]
id: GO:0006373
name: obsolete 3'-splice site cleavage, exon ligation
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:krc]
comment: This term was made obsolete because it represents a molecular function.
synonym: "3'-splice site cleavage, exon ligation" EXACT []
is_obsolete: true
consider: GO:0000386
consider: GO:0000388
consider: GO:0000393

[Term]
id: GO:0006376
name: mRNA splice site selection
namespace: biological_process
def: "Selection of a splice site by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897]
synonym: "spliceosomal commitment complex biosynthesis" NARROW []
synonym: "spliceosomal commitment complex formation" NARROW []
synonym: "spliceosomal E complex biosynthesis" NARROW []
synonym: "spliceosomal E complex formation" NARROW []
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0000245 ! spliceosomal complex assembly

[Term]
id: GO:0006377
name: obsolete MATa1 (A1) pre-mRNA splicing
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:krc]
comment: This term was made obsolete because it does not represent a process unique to splicing of the MATa1 (A1) pre-mRNA, but a recycling defect exacerbated by the presence of two introns within the same gene.
synonym: "MATa1 (A1) pre-mRNA splicing" EXACT []
is_obsolete: true
consider: GO:0000244

[Term]
id: GO:0006378
name: mRNA polyadenylation
namespace: biological_process
def: "The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript." [ISBN:0198506732]
subset: gosubset_prok
synonym: "cleavage and polyadenylylation specificity factor activity" NARROW []
synonym: "mRNA polyadenylylation" EXACT []
is_a: GO:0031124 ! mRNA 3'-end processing
is_a: GO:0043631 ! RNA polyadenylation

[Term]
id: GO:0006379
name: mRNA cleavage
namespace: biological_process
def: "Any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner." [GOC:mah]
subset: gosubset_prok
synonym: "cleavage stimulation factor activity" RELATED []
is_a: GO:0016071 ! mRNA metabolic process
is_a: GO:0090501 ! RNA phosphodiester bond hydrolysis

[Term]
id: GO:0006380
name: obsolete poly-A binding
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a molecular function and not a biological process.
synonym: "poly-A binding" EXACT []
is_obsolete: true
consider: GO:0008143

[Term]
id: GO:0006382
name: adenosine to inosine editing
namespace: biological_process
def: "The conversion of an adenosine residue to inosine in an RNA molecule by deamination." [PMID:11092837]
subset: gosubset_prok
xref: Reactome:REACT_105750 "mRNA Editing: A to I Conversion, Drosophila melanogaster"
xref: Reactome:REACT_106654 "mRNA Editing: A to I Conversion, Canis familiaris"
xref: Reactome:REACT_109758 "mRNA Editing: A to I Conversion, Danio rerio"
xref: Reactome:REACT_112523 "mRNA Editing: A to I Conversion, Saccharomyces cerevisiae"
xref: Reactome:REACT_112594 "mRNA Editing: A to I Conversion, Caenorhabditis elegans"
xref: Reactome:REACT_112784 "mRNA Editing: A to I Conversion, Arabidopsis thaliana"
xref: Reactome:REACT_112897 "mRNA Editing: A to I Conversion, Oryza sativa"
xref: Reactome:REACT_113069 "mRNA Editing: A to I Conversion, Schizosaccharomyces pombe"
xref: Reactome:REACT_18 "mRNA Editing: A to I Conversion, Homo sapiens"
xref: Reactome:REACT_34438 "mRNA Editing: A to I Conversion, Mus musculus"
xref: Reactome:REACT_82741 "mRNA Editing: A to I Conversion, Sus scrofa"
xref: Reactome:REACT_84307 "mRNA Editing: A to I Conversion, Gallus gallus"
xref: Reactome:REACT_89614 "mRNA Editing: A to I Conversion, Xenopus tropicalis"
xref: Reactome:REACT_92259 "mRNA Editing: A to I Conversion, Taeniopygia guttata"
xref: Reactome:REACT_95799 "mRNA Editing: A to I Conversion, Rattus norvegicus"
xref: Reactome:REACT_96163 "mRNA Editing: A to I Conversion, Bos taurus"
is_a: GO:0016553 ! base conversion or substitution editing

[Term]
id: GO:0006383
name: transcription from RNA polymerase III promoter
namespace: biological_process
def: "The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter." [GOC:jl, GOC:txnOH]
subset: goslim_yeast
subset: gosubset_prok
synonym: "RNA polymerase III transcription factor activity" RELATED []
synonym: "transcription from Pol III promoter" EXACT []
xref: Reactome:REACT_100945 "Initiation of RNA Polymerase III Productive Transcription, Schizosaccharomyces pombe"
xref: Reactome:REACT_101038 "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters, Rattus norvegicus"
xref: Reactome:REACT_101551 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites, Canis familiaris"
xref: Reactome:REACT_101656 "RNA Polymerase III Abortive Initiation At Type 3 Open Promoters, Rattus norvegicus"
xref: Reactome:REACT_101661 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites, Mus musculus"
xref: Reactome:REACT_101700 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters, Sus scrofa"
xref: Reactome:REACT_101771 "RNA Polymerase III Promoter Opening at Type 1 Promoters, Gallus gallus"
xref: Reactome:REACT_101901 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites, Danio rerio"
xref: Reactome:REACT_102138 "RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters, Bos taurus"
xref: Reactome:REACT_102603 "RNA Polymerase III Transcription, Gallus gallus"
xref: Reactome:REACT_102683 "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters, Rattus norvegicus"
xref: Reactome:REACT_103091 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites, Caenorhabditis elegans"
xref: Reactome:REACT_103169 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters, Taeniopygia guttata"
xref: Reactome:REACT_103226 "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters, Drosophila melanogaster"
xref: Reactome:REACT_103412 "RNA Polymerase III Abortive Initiation At Type 3 Open Promoters, Mus musculus"
xref: Reactome:REACT_103650 "RNA Polymerase III Transcription, Taeniopygia guttata"
xref: Reactome:REACT_103786 "RNA Polymerase III Abortive Initiation At Type 3 Open Promoters, Sus scrofa"
xref: Reactome:REACT_104805 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites, Schizosaccharomyces pombe"
xref: Reactome:REACT_105112 "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters, Sus scrofa"
xref: Reactome:REACT_105558 "Resumption of RNA Polymerase III Productive Transcription, Dictyostelium discoideum"
xref: Reactome:REACT_105661 "RNA Polymerase III Transcription, Schizosaccharomyces pombe"
xref: Reactome:REACT_106059 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters, Caenorhabditis elegans"
xref: Reactome:REACT_1061 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters, Homo sapiens"
xref: Reactome:REACT_106142 "Initiation of RNA Polymerase III Productive Transcription, Gallus gallus"
xref: Reactome:REACT_106447 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters, Caenorhabditis elegans"
xref: Reactome:REACT_106560 "Initiation of RNA Polymerase III Productive Transcription, Sus scrofa"
xref: Reactome:REACT_106688 "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters, Bos taurus"
xref: Reactome:REACT_106837 "Resumption of RNA Polymerase III Productive Transcription, Mus musculus"
xref: Reactome:REACT_107790 "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters, Taeniopygia guttata"
xref: Reactome:REACT_107815 "RNA Polymerase III Transcription, Saccharomyces cerevisiae"
xref: Reactome:REACT_108150 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites, Gallus gallus"
xref: Reactome:REACT_108254 "RNA Polymerase III Promoter Opening at Type 1 Promoters, Mus musculus"
xref: Reactome:REACT_108736 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites, Sus scrofa"
xref: Reactome:REACT_108779 "Initiation of RNA Polymerase III Productive Transcription, Canis familiaris"
xref: Reactome:REACT_109038 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters, Xenopus tropicalis"
xref: Reactome:REACT_109056 "Resumption of RNA Polymerase III Productive Transcription, Schizosaccharomyces pombe"
xref: Reactome:REACT_109134 "Initiation of RNA Polymerase III Productive Transcription, Drosophila melanogaster"
xref: Reactome:REACT_109293 "RNA Polymerase III Productive Transcription, Mus musculus"
xref: Reactome:REACT_109350 "Resumption of RNA Polymerase III Productive Transcription, Drosophila melanogaster"
xref: Reactome:REACT_109707 "RNA Polymerase III Productive Transcription, Xenopus tropicalis"
xref: Reactome:REACT_109747 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters, Drosophila melanogaster"
xref: Reactome:REACT_109934 "RNA Polymerase III Promoter Opening at Type 1 Promoters, Drosophila melanogaster"
xref: Reactome:REACT_109938 "Initiation of RNA Polymerase III Productive Transcription, Oryza sativa"
xref: Reactome:REACT_110233 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites, Taeniopygia guttata"
xref: Reactome:REACT_110354 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites, Drosophila melanogaster"
xref: Reactome:REACT_110533 "RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters, Rattus norvegicus"
xref: Reactome:REACT_110624 "Initiation of RNA Polymerase III Productive Transcription, Danio rerio"
xref: Reactome:REACT_112623 "RNA Polymerase III Abortive Initiation At Type 3 Open Promoters, Drosophila melanogaster"
xref: Reactome:REACT_112804 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters, Dictyostelium discoideum"
xref: Reactome:REACT_113692 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters, Dictyostelium discoideum"
xref: Reactome:REACT_114988 "RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters, Drosophila melanogaster"
xref: Reactome:REACT_1179 "Initiation of RNA Polymerase III Productive Transcription, Homo sapiens"
xref: Reactome:REACT_118261 "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters, Caenorhabditis elegans"
xref: Reactome:REACT_118310 "RNA Polymerase III Promoter Opening at Type 1 Promoters, Caenorhabditis elegans"
xref: Reactome:REACT_118481 "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters, Caenorhabditis elegans"
xref: Reactome:REACT_1241 "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters, Homo sapiens"
xref: Reactome:REACT_1371 "RNA Polymerase III Transcription, Homo sapiens"
xref: Reactome:REACT_1374 "Resumption of RNA Polymerase III Productive Transcription, Homo sapiens"
xref: Reactome:REACT_1616 "RNA Polymerase III Abortive Initiation At Type 3 Open Promoters, Homo sapiens"
xref: Reactome:REACT_2178 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters, Homo sapiens"
xref: Reactome:REACT_2210 "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters, Homo sapiens"
xref: Reactome:REACT_2248 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites, Homo sapiens"
xref: Reactome:REACT_2251 "RNA Polymerase III Productive Transcription, Homo sapiens"
xref: Reactome:REACT_251 "RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters, Homo sapiens"
xref: Reactome:REACT_28871 "RNA Polymerase III Productive Transcription, Canis familiaris"
xref: Reactome:REACT_28926 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites, Xenopus tropicalis"
xref: Reactome:REACT_29249 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites, Bos taurus"
xref: Reactome:REACT_29589 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters, Canis familiaris"
xref: Reactome:REACT_30206 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters, Canis familiaris"
xref: Reactome:REACT_30383 "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters, Taeniopygia guttata"
xref: Reactome:REACT_30530 "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters, Canis familiaris"
xref: Reactome:REACT_30710 "RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters, Taeniopygia guttata"
xref: Reactome:REACT_30749 "RNA Polymerase III Promoter Opening at Type 1 Promoters, Rattus norvegicus"
xref: Reactome:REACT_30852 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters, Drosophila melanogaster"
xref: Reactome:REACT_30868 "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters, Canis familiaris"
xref: Reactome:REACT_31576 "Resumption of RNA Polymerase III Productive Transcription, Xenopus tropicalis"
xref: Reactome:REACT_31708 "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters, Drosophila melanogaster"
xref: Reactome:REACT_32551 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters, Mus musculus"
xref: Reactome:REACT_32580 "RNA Polymerase III Abortive Initiation At Type 3 Open Promoters, Canis familiaris"
xref: Reactome:REACT_34048 "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters, Bos taurus"
xref: Reactome:REACT_43442 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters, Bos taurus"
xref: Reactome:REACT_50555 "RNA Polymerase III Promoter Opening at Type 1 Promoters, Bos taurus"
xref: Reactome:REACT_76991 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters, Rattus norvegicus"
xref: Reactome:REACT_77583 "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters, Gallus gallus"
xref: Reactome:REACT_77734 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters, Rattus norvegicus"
xref: Reactome:REACT_77763 "RNA Polymerase III Productive Transcription, Rattus norvegicus"
xref: Reactome:REACT_77942 "Initiation of RNA Polymerase III Productive Transcription, Mus musculus"
xref: Reactome:REACT_78034 "Resumption of RNA Polymerase III Productive Transcription, Taeniopygia guttata"
xref: Reactome:REACT_78101 "Resumption of RNA Polymerase III Productive Transcription, Danio rerio"
xref: Reactome:REACT_78330 "RNA Polymerase III Promoter Opening at Type 1 Promoters, Xenopus tropicalis"
xref: Reactome:REACT_78526 "RNA Polymerase III Productive Transcription, Taeniopygia guttata"
xref: Reactome:REACT_79030 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites, Rattus norvegicus"
xref: Reactome:REACT_79212 "Resumption of RNA Polymerase III Productive Transcription, Rattus norvegicus"
xref: Reactome:REACT_79230 "RNA Polymerase III Transcription, Caenorhabditis elegans"
xref: Reactome:REACT_796 "RNA Polymerase III Promoter Opening at Type 1 Promoters, Homo sapiens"
xref: Reactome:REACT_79674 "RNA Polymerase III Transcription, Xenopus tropicalis"
xref: Reactome:REACT_79928 "RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters, Canis familiaris"
xref: Reactome:REACT_80506 "RNA Polymerase III Productive Transcription, Gallus gallus"
xref: Reactome:REACT_80530 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters, Danio rerio"
xref: Reactome:REACT_80924 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites, Arabidopsis thaliana"
xref: Reactome:REACT_81033 "RNA Polymerase III Productive Transcription, Schizosaccharomyces pombe"
xref: Reactome:REACT_81681 "Resumption of RNA Polymerase III Productive Transcription, Canis familiaris"
xref: Reactome:REACT_82476 "RNA Polymerase III Productive Transcription, Sus scrofa"
xref: Reactome:REACT_82823 "RNA Polymerase III Transcription, Bos taurus"
xref: Reactome:REACT_82958 "RNA Polymerase III Transcription, Rattus norvegicus"
xref: Reactome:REACT_83072 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters, Gallus gallus"
xref: Reactome:REACT_83162 "Resumption of RNA Polymerase III Productive Transcription, Gallus gallus"
xref: Reactome:REACT_83237 "RNA Polymerase III Transcription, Danio rerio"
xref: Reactome:REACT_83573 "RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters, Danio rerio"
xref: Reactome:REACT_83679 "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters, Mus musculus"
xref: Reactome:REACT_83791 "RNA Polymerase III Promoter Opening at Type 1 Promoters, Taeniopygia guttata"
xref: Reactome:REACT_84005 "RNA Polymerase III Transcription, Sus scrofa"
xref: Reactome:REACT_84052 "RNA Polymerase III Abortive Initiation At Type 3 Open Promoters, Xenopus tropicalis"
xref: Reactome:REACT_84174 "RNA Polymerase III Transcription, Canis familiaris"
xref: Reactome:REACT_84770 "RNA Polymerase III Transcription, Arabidopsis thaliana"
xref: Reactome:REACT_85321 "RNA Polymerase III Abortive Initiation At Type 3 Open Promoters, Gallus gallus"
xref: Reactome:REACT_85665 "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters, Danio rerio"
xref: Reactome:REACT_85700 "RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters, Sus scrofa"
xref: Reactome:REACT_85938 "RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters, Gallus gallus"
xref: Reactome:REACT_86188 "Initiation of RNA Polymerase III Productive Transcription, Dictyostelium discoideum"
xref: Reactome:REACT_86214 "RNA Polymerase III Productive Transcription, Danio rerio"
xref: Reactome:REACT_86477 "Resumption of RNA Polymerase III Productive Transcription, Sus scrofa"
xref: Reactome:REACT_86680 "RNA Polymerase III Productive Transcription, Bos taurus"
xref: Reactome:REACT_87495 "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters, Danio rerio"
xref: Reactome:REACT_88180 "RNA Polymerase III Promoter Opening at Type 1 Promoters, Canis familiaris"
xref: Reactome:REACT_88328 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters, Taeniopygia guttata"
xref: Reactome:REACT_89113 "Initiation of RNA Polymerase III Productive Transcription, Bos taurus"
xref: Reactome:REACT_89159 "RNA Polymerase III Productive Transcription, Drosophila melanogaster"
xref: Reactome:REACT_89744 "RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters, Mus musculus"
xref: Reactome:REACT_90232 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters, Mus musculus"
xref: Reactome:REACT_90884 "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters, Sus scrofa"
xref: Reactome:REACT_90929 "Initiation of RNA Polymerase III Productive Transcription, Taeniopygia guttata"
xref: Reactome:REACT_90945 "Initiation of RNA Polymerase III Productive Transcription, Arabidopsis thaliana"
xref: Reactome:REACT_90947 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters, Danio rerio"
xref: Reactome:REACT_91182 "RNA Polymerase III Transcription, Drosophila melanogaster"
xref: Reactome:REACT_91223 "RNA Polymerase III Abortive Initiation At Type 3 Open Promoters, Taeniopygia guttata"
xref: Reactome:REACT_91433 "Initiation of RNA Polymerase III Productive Transcription, Rattus norvegicus"
xref: Reactome:REACT_92510 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters, Bos taurus"
xref: Reactome:REACT_92565 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters, Gallus gallus"
xref: Reactome:REACT_92674 "RNA Polymerase III Promoter Opening at Type 1 Promoters, Sus scrofa"
xref: Reactome:REACT_92814 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters, Xenopus tropicalis"
xref: Reactome:REACT_92970 "RNA Polymerase III Transcription, Oryza sativa"
xref: Reactome:REACT_93003 "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters, Xenopus tropicalis"
xref: Reactome:REACT_93041 "RNA Polymerase III Productive Transcription, Oryza sativa"
xref: Reactome:REACT_93262 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites, Oryza sativa"
xref: Reactome:REACT_93305 "Resumption of RNA Polymerase III Productive Transcription, Arabidopsis thaliana"
xref: Reactome:REACT_93548 "RNA Polymerase III Transcription, Dictyostelium discoideum"
xref: Reactome:REACT_93709 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites, Dictyostelium discoideum"
xref: Reactome:REACT_93754 "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters, Gallus gallus"
xref: Reactome:REACT_93859 "RNA Polymerase III Productive Transcription, Arabidopsis thaliana"
xref: Reactome:REACT_94189 "RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters, Xenopus tropicalis"
xref: Reactome:REACT_94421 "RNA Polymerase III Transcription, Mus musculus"
xref: Reactome:REACT_94567 "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters, Xenopus tropicalis"
xref: Reactome:REACT_94753 "Resumption of RNA Polymerase III Productive Transcription, Oryza sativa"
xref: Reactome:REACT_96798 "Resumption of RNA Polymerase III Productive Transcription, Caenorhabditis elegans"
xref: Reactome:REACT_97406 "Initiation of RNA Polymerase III Productive Transcription, Xenopus tropicalis"
xref: Reactome:REACT_97559 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters, Sus scrofa"
xref: Reactome:REACT_98079 "RNA Polymerase III Productive Transcription, Dictyostelium discoideum"
xref: Reactome:REACT_98254 "RNA Polymerase III Abortive Initiation At Type 3 Open Promoters, Bos taurus"
xref: Reactome:REACT_98466 "RNA Polymerase III Abortive Initiation At Type 3 Open Promoters, Danio rerio"
xref: Reactome:REACT_98470 "Resumption of RNA Polymerase III Productive Transcription, Bos taurus"
xref: Reactome:REACT_98660 "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters, Mus musculus"
xref: Reactome:REACT_98770 "RNA Polymerase III Productive Transcription, Caenorhabditis elegans"
xref: Reactome:REACT_99332 "RNA Polymerase III Promoter Opening at Type 1 Promoters, Danio rerio"
xref: Reactome:REACT_99492 "Initiation of RNA Polymerase III Productive Transcription, Caenorhabditis elegans"
is_a: GO:0006351 ! transcription, DNA-templated

[Term]
id: GO:0006384
name: transcription initiation from RNA polymerase III promoter
namespace: biological_process
def: "Any process involved in the assembly of the RNA polymerase III preinitiation complex (PIC) at an RNA polymerase III promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH]
comment: Note that promoter clearance is represented as a separate step, not part_of either initiation or elongation.
synonym: "transcription initiation from Pol III promoter" EXACT []
is_a: GO:0006352 ! DNA-templated transcription, initiation
relationship: part_of GO:0006383 ! transcription from RNA polymerase III promoter

[Term]
id: GO:0006385
name: transcription elongation from RNA polymerase III promoter
namespace: biological_process
def: "The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase III promoter by the addition of ribonucleotides catalyzed by RNA polymerase III." [GOC:mah, GOC:txnOH]
synonym: "RNA elongation from Pol III promoter" EXACT []
synonym: "RNA polymerase III transcription elongation factor activity" RELATED []
xref: Reactome:REACT_100029 "RNA Polymerase III Chain Elongation, Danio rerio"
xref: Reactome:REACT_104942 "RNA Polymerase III Chain Elongation, Caenorhabditis elegans"
xref: Reactome:REACT_109063 "RNA Polymerase III Chain Elongation, Taeniopygia guttata"
xref: Reactome:REACT_28198 "RNA Polymerase III Chain Elongation, Bos taurus"
xref: Reactome:REACT_33298 "RNA Polymerase III Chain Elongation, Oryza sativa"
xref: Reactome:REACT_33917 "RNA Polymerase III Chain Elongation, Arabidopsis thaliana"
xref: Reactome:REACT_756 "RNA Polymerase III Chain Elongation, Homo sapiens"
xref: Reactome:REACT_77630 "RNA Polymerase III Chain Elongation, Dictyostelium discoideum"
xref: Reactome:REACT_78831 "RNA Polymerase III Chain Elongation, Saccharomyces cerevisiae"
xref: Reactome:REACT_78988 "RNA Polymerase III Chain Elongation, Xenopus tropicalis"
xref: Reactome:REACT_79358 "RNA Polymerase III Chain Elongation, Canis familiaris"
xref: Reactome:REACT_83012 "RNA Polymerase III Chain Elongation, Drosophila melanogaster"
xref: Reactome:REACT_89687 "RNA Polymerase III Chain Elongation, Rattus norvegicus"
xref: Reactome:REACT_91878 "RNA Polymerase III Chain Elongation, Mus musculus"
xref: Reactome:REACT_94842 "RNA Polymerase III Chain Elongation, Schizosaccharomyces pombe"
xref: Reactome:REACT_94891 "RNA Polymerase III Chain Elongation, Gallus gallus"
xref: Reactome:REACT_97511 "RNA Polymerase III Chain Elongation, Sus scrofa"
is_a: GO:0006354 ! DNA-templated transcription, elongation
relationship: part_of GO:0006383 ! transcription from RNA polymerase III promoter

[Term]
id: GO:0006386
name: termination of RNA polymerase III transcription
namespace: biological_process
alt_id: GO:0019225
def: "The process in which transcription by RNA polymerase III is terminated; Pol III has an intrinsic ability to terminate transcription upon incorporation of 4 to 6 contiguous U residues." [GOC:mah, PMID:12944462]
synonym: "RNA polymerase III transcription termination" EXACT []
synonym: "RNA polymerase III transcription termination factor activity" RELATED []
synonym: "transcription termination from Pol III promoter" EXACT []
synonym: "transcription termination from RNA polymerase III promoter" EXACT []
xref: Reactome:REACT_101346 "RNA Polymerase III Termination and release of transcribed mRNA, Oryza sativa"
xref: Reactome:REACT_103761 "RNA Polymerase III Transcription Termination, Canis familiaris"
xref: Reactome:REACT_104517 "RNA Polymerase III Transcription Termination, Drosophila melanogaster"
xref: Reactome:REACT_106285 "RNA Polymerase III Transcription Termination, Dictyostelium discoideum"
xref: Reactome:REACT_107620 "RNA Polymerase III Termination and release of transcribed mRNA, Rattus norvegicus"
xref: Reactome:REACT_107641 "RNA Polymerase III Termination and release of transcribed mRNA, Sus scrofa"
xref: Reactome:REACT_110732 "RNA Polymerase III Termination and release of transcribed mRNA, Schizosaccharomyces pombe"
xref: Reactome:REACT_1301 "RNA Polymerase III Termination and release of transcribed mRNA, Homo sapiens"
xref: Reactome:REACT_30092 "RNA Polymerase III Termination and release of transcribed mRNA, Caenorhabditis elegans"
xref: Reactome:REACT_32584 "RNA Polymerase III Termination and release of transcribed mRNA, Mus musculus"
xref: Reactome:REACT_33507 "RNA Polymerase III Transcription Termination, Schizosaccharomyces pombe"
xref: Reactome:REACT_473 "RNA Polymerase III Transcriptional Pause at Terminator Sequence, Saccharomyces cerevisiae"
xref: Reactome:REACT_63 "RNA Polymerase III Transcription Termination, Homo sapiens"
xref: Reactome:REACT_76992 "RNA Polymerase III Termination and release of transcribed mRNA, Arabidopsis thaliana"
xref: Reactome:REACT_78944 "RNA Polymerase III Transcription Termination, Danio rerio"
xref: Reactome:REACT_79014 "RNA Polymerase III Transcription Termination, Saccharomyces cerevisiae"
xref: Reactome:REACT_81629 "RNA Polymerase III Transcription Termination, Taeniopygia guttata"
xref: Reactome:REACT_82545 "RNA Polymerase III Transcription Termination, Rattus norvegicus"
xref: Reactome:REACT_84701 "RNA Polymerase III Transcription Termination, Caenorhabditis elegans"
xref: Reactome:REACT_84717 "RNA Polymerase III Termination and release of transcribed mRNA, Taeniopygia guttata"
xref: Reactome:REACT_84919 "RNA Polymerase III Transcription Termination, Sus scrofa"
xref: Reactome:REACT_84942 "RNA Polymerase III Termination and release of transcribed mRNA, Danio rerio"
xref: Reactome:REACT_85666 "RNA Polymerase III Transcription Termination, Gallus gallus"
xref: Reactome:REACT_86112 "RNA Polymerase III Transcription Termination, Arabidopsis thaliana"
xref: Reactome:REACT_86418 "RNA Polymerase III Transcription Termination, Xenopus tropicalis"
xref: Reactome:REACT_878 "RNA Polymerase III Termination and release of transcribed mRNA, Saccharomyces cerevisiae"
xref: Reactome:REACT_88719 "RNA Polymerase III Termination and release of transcribed mRNA, Gallus gallus"
xref: Reactome:REACT_89703 "RNA Polymerase III Transcription Termination, Bos taurus"
xref: Reactome:REACT_90819 "RNA Polymerase III Termination and release of transcribed mRNA, Bos taurus"
xref: Reactome:REACT_92558 "RNA Polymerase III Termination and release of transcribed mRNA, Dictyostelium discoideum"
xref: Reactome:REACT_94195 "RNA Polymerase III Termination and release of transcribed mRNA, Xenopus tropicalis"
xref: Reactome:REACT_95268 "RNA Polymerase III Transcription Termination, Mus musculus"
xref: Reactome:REACT_95372 "RNA Polymerase III Termination and release of transcribed mRNA, Drosophila melanogaster"
xref: Reactome:REACT_97380 "RNA Polymerase III Transcription Termination, Oryza sativa"
xref: Reactome:REACT_99081 "RNA Polymerase III Termination and release of transcribed mRNA, Canis familiaris"
is_a: GO:0006353 ! DNA-templated transcription, termination
relationship: part_of GO:0006383 ! transcription from RNA polymerase III promoter

[Term]
id: GO:0006387
name: obsolete snRNA capping
namespace: biological_process
def: "OBSOLETE. The sequence of enzymatic reactions resulting in the addition of a cap to the 5' end of a nascent snRNA transcript." [GOC:mah]
comment: This term was made obsolete because it has been replaced with a more specific term to describe cap hypermethylation. All RNA polymerase II transcripts receive a 7-methyl-G cap. Then for (at least) small nuclear RNAs (snRNAs) and small nucleolar RNAs (snoRNAs), the 7-methyl-G cap is hypermethylated to become a 2,2,7-trimethylguanosine (TMG) cap.
synonym: "snRNA capping" EXACT []
is_obsolete: true
consider: GO:0036261

[Term]
id: GO:0006388
name: tRNA splicing, via endonucleolytic cleavage and ligation
namespace: biological_process
def: "Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons." [GOC:krc, ISBN:0879695897, PMID:9582290]
comment: Note that while typically associated with tRNA splicing, splicing via endonucleolytic cleavages and subsequent ligation of the free exon ends is known to be used for some non-tRNA substrates, e.g. HAC1 (YFL031W) in S. cerevisiae and an intron in the 23S rRNA of the Archaeal species Desulfurococcus mobilis.
subset: gosubset_prok
synonym: "tRNA-Y splicing" NARROW []
is_a: GO:0000394 ! RNA splicing, via endonucleolytic cleavage and ligation
is_a: GO:0008033 ! tRNA processing

[Term]
id: GO:0006389
name: obsolete tRNA-Y splicing
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:krc]
comment: This term was made obsolete because it does not represent a process unique to splicing of the tyrosyl (Y) tRNA.
synonym: "tRNA-Y splicing" EXACT []
is_obsolete: true
consider: GO:0006388

[Term]
id: GO:0006390
name: transcription from mitochondrial promoter
namespace: biological_process
def: "The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase." [GOC:jl]
synonym: "mitochondrial transcription" EXACT []
xref: Reactome:REACT_105472 "Transcription from mitochondrial promoters, Rattus norvegicus"
xref: Reactome:REACT_107715 "Transcription from mitochondrial promoters, Bos taurus"
xref: Reactome:REACT_1484 "Transcription from mitochondrial promoters, Homo sapiens"
xref: Reactome:REACT_32274 "Transcription from mitochondrial promoters, Sus scrofa"
xref: Reactome:REACT_34725 "Transcription from mitochondrial promoters, Drosophila melanogaster"
xref: Reactome:REACT_78264 "Transcription from mitochondrial promoters, Taeniopygia guttata"
xref: Reactome:REACT_82329 "Transcription from mitochondrial promoters, Danio rerio"
xref: Reactome:REACT_88757 "Transcription from mitochondrial promoters, Caenorhabditis elegans"
xref: Reactome:REACT_91390 "Transcription from mitochondrial promoters, Xenopus tropicalis"
xref: Reactome:REACT_95939 "Transcription from mitochondrial promoters, Canis familiaris"
xref: Reactome:REACT_97569 "Transcription from mitochondrial promoters, Gallus gallus"
xref: Reactome:REACT_97823 "Transcription from mitochondrial promoters, Mus musculus"
is_a: GO:0000959 ! mitochondrial RNA metabolic process
is_a: GO:0006351 ! transcription, DNA-templated
is_a: GO:0007005 ! mitochondrion organization
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:1902589 ! single-organism organelle organization
intersection_of: GO:0006351 ! transcription, DNA-templated
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion

[Term]
id: GO:0006391
name: transcription initiation from mitochondrial promoter
namespace: biological_process
def: "A transcription initiation process that takes place at a promoter on the mitochondrial chromosome, and results in RNA synthesis by a mitochondrial RNA polymerase." [GOC:mah]
xref: Reactome:REACT_110103 "Mitochondrial transcription initiation, Drosophila melanogaster"
xref: Reactome:REACT_29893 "Mitochondrial transcription initiation, Taeniopygia guttata"
xref: Reactome:REACT_31772 "Mitochondrial transcription initiation, Bos taurus"
xref: Reactome:REACT_33467 "Mitochondrial transcription initiation, Canis familiaris"
xref: Reactome:REACT_367 "Mitochondrial transcription initiation, Homo sapiens"
xref: Reactome:REACT_61705 "Mitochondrial transcription initiation, Gallus gallus"
xref: Reactome:REACT_85305 "Mitochondrial transcription initiation, Sus scrofa"
xref: Reactome:REACT_86086 "Mitochondrial transcription initiation, Rattus norvegicus"
xref: Reactome:REACT_87798 "Mitochondrial transcription initiation, Xenopus tropicalis"
xref: Reactome:REACT_88905 "Mitochondrial transcription initiation, Mus musculus"
xref: Reactome:REACT_90633 "Mitochondrial transcription initiation, Caenorhabditis elegans"
xref: Reactome:REACT_91065 "Mitochondrial transcription initiation, Danio rerio"
is_a: GO:0000959 ! mitochondrial RNA metabolic process
is_a: GO:0006352 ! DNA-templated transcription, initiation
relationship: part_of GO:0006390 ! transcription from mitochondrial promoter

[Term]
id: GO:0006392
name: transcription elongation from mitochondrial promoter
namespace: biological_process
def: "The extension of an RNA molecule after transcription initiation and promoter clearance at mitochondrial promoter by the addition of ribonucleotides catalyzed by a mitchondrial RNA polymerase." [GOC:mah, GOC:txnOH]
synonym: "RNA elongation from mitochondrial promoter" EXACT []
is_a: GO:0000959 ! mitochondrial RNA metabolic process
is_a: GO:0006354 ! DNA-templated transcription, elongation
relationship: part_of GO:0006390 ! transcription from mitochondrial promoter

[Term]
id: GO:0006393
name: termination of mitochondrial transcription
namespace: biological_process
def: "The process in which the synthesis of an RNA molecule using a mitochondrial DNA template is completed." [GOC:mah]
synonym: "mitochondrial transcription termination" EXACT []
synonym: "RNA transcription termination from mitochondrial promoter" EXACT []
xref: Reactome:REACT_28906 "Mitochondrial transcription termination, Rattus norvegicus"
xref: Reactome:REACT_610 "Mitochondrial transcription termination, Homo sapiens"
xref: Reactome:REACT_78733 "Mitochondrial transcription termination, Canis familiaris"
xref: Reactome:REACT_83191 "Mitochondrial transcription termination, Sus scrofa"
xref: Reactome:REACT_84941 "Mitochondrial transcription termination, Mus musculus"
xref: Reactome:REACT_87729 "Mitochondrial transcription termination, Danio rerio"
xref: Reactome:REACT_89280 "Mitochondrial transcription termination, Xenopus tropicalis"
is_a: GO:0000959 ! mitochondrial RNA metabolic process
is_a: GO:0006353 ! DNA-templated transcription, termination
intersection_of: GO:0006353 ! DNA-templated transcription, termination
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion
relationship: part_of GO:0006390 ! transcription from mitochondrial promoter

[Term]
id: GO:0006396
name: RNA processing
namespace: biological_process
alt_id: GO:0006394
def: "Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]
subset: goslim_pir
subset: gosubset_prok
xref: Wikipedia:Post-transcriptional_modification
is_a: GO:0016070 ! RNA metabolic process
relationship: part_of GO:0010467 ! gene expression

[Term]
id: GO:0006397
name: mRNA processing
namespace: biological_process
def: "Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_yeast
subset: gosubset_prok
synonym: "mRNA maturation" RELATED []
xref: Reactome:REACT_100203 "Processing of Capped Intronless Pre-mRNA, Dictyostelium discoideum"
xref: Reactome:REACT_107308 "Processing of Capped Intronless Pre-mRNA, Xenopus tropicalis"
xref: Reactome:REACT_109953 "Processing of Capped Intronless Pre-mRNA, Canis familiaris"
xref: Reactome:REACT_113864 "Processing of Capped Intronless Pre-mRNA, Saccharomyces cerevisiae"
xref: Reactome:REACT_114358 "Processing of Capped Intronless Pre-mRNA, Schizosaccharomyces pombe"
xref: Reactome:REACT_115262 "Processing of Capped Intronless Pre-mRNA, Arabidopsis thaliana"
xref: Reactome:REACT_1768 "Processing of Capped Intronless Pre-mRNA, Homo sapiens"
xref: Reactome:REACT_32742 "Processing of Capped Intronless Pre-mRNA, Bos taurus"
xref: Reactome:REACT_33642 "Processing of Capped Intronless Pre-mRNA, Caenorhabditis elegans"
xref: Reactome:REACT_82691 "Processing of Capped Intronless Pre-mRNA, Gallus gallus"
xref: Reactome:REACT_90366 "Processing of Capped Intronless Pre-mRNA, Drosophila melanogaster"
xref: Reactome:REACT_91511 "Processing of Capped Intronless Pre-mRNA, Danio rerio"
xref: Reactome:REACT_93186 "Processing of Capped Intronless Pre-mRNA, Sus scrofa"
xref: Reactome:REACT_94083 "Processing of Capped Intronless Pre-mRNA, Taeniopygia guttata"
xref: Reactome:REACT_96661 "Processing of Capped Intronless Pre-mRNA, Oryza sativa"
xref: Reactome:REACT_97412 "Processing of Capped Intronless Pre-mRNA, Rattus norvegicus"
xref: Reactome:REACT_97436 "Processing of Capped Intronless Pre-mRNA, Mus musculus"
is_a: GO:0006396 ! RNA processing
is_a: GO:0016071 ! mRNA metabolic process

[Term]
id: GO:0006398
name: mRNA 3'-end processing by stem-loop binding and cleavage
namespace: biological_process
def: "Any mRNA 3'-end processing that involves the binding to and cleavage of a stem-loop structure. For example, histone mRNAs contain a highly conserved stem-loop sequence at the 3' end of the mRNA with a 6 base pairs (bp) stem and a 4-nt loop. The mRNA is cleaved between these two elements, after the fourth or fifth nucleotide, which is typically an adenosine." [GOC:mah, GOC:tb, PMID:17998288]
synonym: "histone mRNA 3' end processing" NARROW []
is_a: GO:0008334 ! histone mRNA metabolic process
is_a: GO:0031124 ! mRNA 3'-end processing

[Term]
id: GO:0006399
name: tRNA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. Transfer RNA is characterized by the presence of many unusual minor bases, the function of which has not been completely established." [ISBN:0198506732]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_pombe
subset: gosubset_prok
synonym: "tRNA metabolism" EXACT []
is_a: GO:0034660 ! ncRNA metabolic process

[Term]
id: GO:0006400
name: tRNA modification
namespace: biological_process
alt_id: GO:0016549
def: "The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]
comment: The term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing. Parallel changes were made for substrate (e.g. tRNA, rRNA, etc.) specific child terms of 'RNA editing'.
subset: gosubset_prok
synonym: "tRNA editing" NARROW [GOC:hjd]
is_a: GO:0008033 ! tRNA processing
is_a: GO:0009451 ! RNA modification

[Term]
id: GO:0006401
name: RNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732]
subset: goslim_yeast
subset: gosubset_prok
synonym: "RNA breakdown" EXACT []
synonym: "RNA catabolism" EXACT []
synonym: "RNA degradation" EXACT []
is_a: GO:0016070 ! RNA metabolic process
is_a: GO:0034655 ! nucleobase-containing compound catabolic process
is_a: GO:0044265 ! cellular macromolecule catabolic process

[Term]
id: GO:0006402
name: mRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732]
subset: gosubset_prok
synonym: "mRNA breakdown" EXACT []
synonym: "mRNA catabolism" EXACT []
synonym: "mRNA decay" RELATED [GOC:ascb_2010, GOC:dph, GOC:tb]
synonym: "mRNA degradation" EXACT []
is_a: GO:0006401 ! RNA catabolic process
is_a: GO:0016071 ! mRNA metabolic process

[Term]
id: GO:0006403
name: RNA localization
namespace: biological_process
def: "A process in which RNA is transported to, or maintained in, a specific location." [GOC:ai]
subset: gosubset_prok
synonym: "establishment and maintenance of RNA localization" EXACT []
synonym: "RNA localisation" EXACT [GOC:mah]
is_a: GO:0033036 ! macromolecule localization

[Term]
id: GO:0006404
name: RNA import into nucleus
namespace: biological_process
def: "The import of RNA from the cytoplasm to the nucleus." [GOC:ma]
synonym: "RNA import into cell nucleus" EXACT []
synonym: "RNA transport from cytoplasm to nucleus" EXACT []
synonym: "RNA-nucleus import" EXACT []
is_a: GO:0050658 ! RNA transport
is_a: GO:0051170 ! nuclear import

[Term]
id: GO:0006405
name: RNA export from nucleus
namespace: biological_process
def: "The directed movement of RNA from the nucleus to the cytoplasm." [GOC:ma]
synonym: "RNA export from cell nucleus" EXACT []
synonym: "RNA export out of nucleus" EXACT []
synonym: "RNA transport from nucleus to cytoplasm" EXACT []
synonym: "RNA-nucleus export" EXACT []
xref: Reactome:REACT_1004 "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC, Homo sapiens"
xref: Reactome:REACT_104043 "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC, Danio rerio"
xref: Reactome:REACT_108003 "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC, Bos taurus"
xref: Reactome:REACT_114184 "Recruitment of TAP to the EJC, Drosophila melanogaster"
xref: Reactome:REACT_1334 "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC, Homo sapiens"
xref: Reactome:REACT_29222 "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC, Mus musculus"
xref: Reactome:REACT_30837 "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC, Rattus norvegicus"
xref: Reactome:REACT_30884 "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC, Xenopus tropicalis"
xref: Reactome:REACT_53 "Recruitment of TAP to the EJC, Homo sapiens"
xref: Reactome:REACT_78063 "Recruitment of TAP to the EJC, Xenopus tropicalis"
xref: Reactome:REACT_80132 "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC, Xenopus tropicalis"
xref: Reactome:REACT_80198 "Recruitment of TAP to the EJC, Mus musculus"
xref: Reactome:REACT_80579 "Recruitment of TAP to the EJC, Danio rerio"
xref: Reactome:REACT_81658 "Recruitment of TAP to the EJC, Bos taurus"
xref: Reactome:REACT_82156 "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC, Bos taurus"
xref: Reactome:REACT_82661 "Recruitment of TAP to the EJC, Canis familiaris"
xref: Reactome:REACT_84373 "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC, Danio rerio"
xref: Reactome:REACT_84418 "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC, Canis familiaris"
xref: Reactome:REACT_85495 "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC, Canis familiaris"
xref: Reactome:REACT_86488 "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC, Canis familiaris"
xref: Reactome:REACT_87758 "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC, Xenopus tropicalis"
xref: Reactome:REACT_89603 "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC, Rattus norvegicus"
xref: Reactome:REACT_904 "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC, Homo sapiens"
xref: Reactome:REACT_90560 "Recruitment of TAP to the EJC, Rattus norvegicus"
xref: Reactome:REACT_91473 "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC, Rattus norvegicus"
xref: Reactome:REACT_92226 "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC, Mus musculus"
xref: Reactome:REACT_95332 "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC, Bos taurus"
xref: Reactome:REACT_98342 "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC, Mus musculus"
xref: Reactome:REACT_99708 "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC, Danio rerio"
is_a: GO:0050658 ! RNA transport
is_a: GO:0051168 ! nuclear export

[Term]
id: GO:0006406
name: mRNA export from nucleus
namespace: biological_process
def: "The directed movement of mRNA from the nucleus to the cytoplasm." [GOC:ma]
synonym: "mRNA export from cell nucleus" EXACT []
synonym: "mRNA export out of nucleus" EXACT []
synonym: "mRNA transport from nucleus to cytoplasm" EXACT []
synonym: "mRNA-nucleus export" EXACT []
xref: Reactome:REACT_100171 "Release of the SLBP independent Histone mRNA from the NPC, Canis familiaris"
xref: Reactome:REACT_100279 "Transport of the export-competent complex through the NPC, Drosophila melanogaster"
xref: Reactome:REACT_100965 "Transport of Mature Transcript to Cytoplasm, Canis familiaris"
xref: Reactome:REACT_102835 "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC, Xenopus tropicalis"
xref: Reactome:REACT_102954 "Transport of Mature Transcript to Cytoplasm, Rattus norvegicus"
xref: Reactome:REACT_103864 "Release of the SLBP independent Histone mRNA from the NPC, Rattus norvegicus"
xref: Reactome:REACT_103981 "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex, Danio rerio"
xref: Reactome:REACT_1044 "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex, Homo sapiens"
xref: Reactome:REACT_104948 "Transport of Mature mRNAs Derived from Intronless Transcripts, Danio rerio"
xref: Reactome:REACT_105234 "Transport of the export-competent complex through the NPC, Rattus norvegicus"
xref: Reactome:REACT_105457 "Docking of Mature Replication Dependent Histone mRNA with the NPC, Canis familiaris"
xref: Reactome:REACT_106001 "Release from the NPC and Disassembly of the mRNP, Canis familiaris"
xref: Reactome:REACT_106656 "Transport of Mature Transcript to Cytoplasm, Bos taurus"
xref: Reactome:REACT_107365 "Transport of Mature mRNA derived from an Intron-Containing Transcript, Taeniopygia guttata"
xref: Reactome:REACT_107514 "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex, Mus musculus"
xref: Reactome:REACT_108228 "Transport of Mature mRNA derived from an Intron-Containing Transcript, Bos taurus"
xref: Reactome:REACT_108856 "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex, Rattus norvegicus"
xref: Reactome:REACT_109933 "Docking of Mature Replication Dependent Histone mRNA with the NPC, Rattus norvegicus"
xref: Reactome:REACT_109937 "Docking of Mature Histone mRNA complex:TAP at the NPC, Mus musculus"
xref: Reactome:REACT_112057 "Docking of Mature Replication Dependent Histone mRNA with the NPC, Danio rerio"
xref: Reactome:REACT_113695 "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC, Danio rerio"
xref: Reactome:REACT_114603 "Docking of Mature Histone mRNA complex:TAP at the NPC, Danio rerio"
xref: Reactome:REACT_1228 "Release from the NPC and Disassembly of the mRNP, Homo sapiens"
xref: Reactome:REACT_1281 "Transport of Mature Transcript to Cytoplasm, Homo sapiens"
xref: Reactome:REACT_1356 "Release of the SLBP independent Histone mRNA from the NPC, Homo sapiens"
xref: Reactome:REACT_138 "Docking of the TAP:EJC Complex with the NPC, Homo sapiens"
xref: Reactome:REACT_1597 "Transport of Mature mRNA derived from an Intron-Containing Transcript, Homo sapiens"
xref: Reactome:REACT_1604 "Docking of Mature Replication Dependent Histone mRNA with the NPC, Homo sapiens"
xref: Reactome:REACT_1799 "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC, Homo sapiens"
xref: Reactome:REACT_1897 "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC, Homo sapiens"
xref: Reactome:REACT_2104 "Transport of the export-competent complex through the NPC, Homo sapiens"
xref: Reactome:REACT_29248 "Docking of Mature Histone mRNA complex:TAP at the NPC, Xenopus tropicalis"
xref: Reactome:REACT_30031 "Docking of Mature Histone mRNA complex:TAP at the NPC, Rattus norvegicus"
xref: Reactome:REACT_30081 "Docking of Mature Histone mRNA complex:TAP at the NPC, Canis familiaris"
xref: Reactome:REACT_30429 "Transport of Mature Transcript to Cytoplasm, Drosophila melanogaster"
xref: Reactome:REACT_30966 "Transport of Mature Transcript to Cytoplasm, Taeniopygia guttata"
xref: Reactome:REACT_33590 "Transport of Mature Transcript to Cytoplasm, Mus musculus"
xref: Reactome:REACT_338 "Transport of Mature mRNAs Derived from Intronless Transcripts, Homo sapiens"
xref: Reactome:REACT_34117 "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC, Canis familiaris"
xref: Reactome:REACT_52228 "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC, Bos taurus"
xref: Reactome:REACT_61073 "Docking of Mature Replication Dependent Histone mRNA with the NPC, Bos taurus"
xref: Reactome:REACT_696 "Docking of Mature Histone mRNA complex:TAP at the NPC, Homo sapiens"
xref: Reactome:REACT_78291 "Docking of Mature Replication Dependent Histone mRNA with the NPC, Xenopus tropicalis"
xref: Reactome:REACT_80859 "Release of the SLBP independent Histone mRNA from the NPC, Xenopus tropicalis"
xref: Reactome:REACT_81039 "Release of the SLBP independent Histone mRNA from the NPC, Danio rerio"
xref: Reactome:REACT_81535 "Transport of Mature mRNA derived from an Intron-Containing Transcript, Xenopus tropicalis"
xref: Reactome:REACT_81663 "Docking of Mature Replication Dependent Histone mRNA with the NPC, Mus musculus"
xref: Reactome:REACT_81712 "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC, Mus musculus"
xref: Reactome:REACT_82141 "Transport of Mature mRNA derived from an Intron-Containing Transcript, Rattus norvegicus"
xref: Reactome:REACT_82514 "Transport of Mature mRNAs Derived from Intronless Transcripts, Rattus norvegicus"
xref: Reactome:REACT_82894 "Transport of Mature mRNAs Derived from Intronless Transcripts, Bos taurus"
xref: Reactome:REACT_83050 "Release of the SLBP independent Histone mRNA from the NPC, Bos taurus"
xref: Reactome:REACT_83394 "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC, Canis familiaris"
xref: Reactome:REACT_83855 "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC, Danio rerio"
xref: Reactome:REACT_84109 "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex, Canis familiaris"
xref: Reactome:REACT_85191 "Release of the SLBP independent Histone mRNA from the NPC, Mus musculus"
xref: Reactome:REACT_85251 "Release from the NPC and Disassembly of the mRNP, Danio rerio"
xref: Reactome:REACT_86131 "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC, Xenopus tropicalis"
xref: Reactome:REACT_87203 "Transport of the export-competent complex through the NPC, Canis familiaris"
xref: Reactome:REACT_87607 "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC, Rattus norvegicus"
xref: Reactome:REACT_89199 "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC, Mus musculus"
xref: Reactome:REACT_89255 "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC, Bos taurus"
xref: Reactome:REACT_90322 "Transport of Mature mRNAs Derived from Intronless Transcripts, Xenopus tropicalis"
xref: Reactome:REACT_90737 "Transport of the export-competent complex through the NPC, Danio rerio"
xref: Reactome:REACT_91492 "Transport of the export-competent complex through the NPC, Taeniopygia guttata"
xref: Reactome:REACT_92414 "Transport of the export-competent complex through the NPC, Mus musculus"
xref: Reactome:REACT_93318 "Transport of Mature mRNAs Derived from Intronless Transcripts, Mus musculus"
xref: Reactome:REACT_93526 "Transport of Mature Transcript to Cytoplasm, Danio rerio"
xref: Reactome:REACT_93638 "Transport of Mature mRNA derived from an Intron-Containing Transcript, Danio rerio"
xref: Reactome:REACT_93805 "Release from the NPC and Disassembly of the mRNP, Mus musculus"
xref: Reactome:REACT_94770 "Transport of Mature mRNA derived from an Intron-Containing Transcript, Mus musculus"
xref: Reactome:REACT_95557 "Docking of Mature Histone mRNA complex:TAP at the NPC, Bos taurus"
xref: Reactome:REACT_95729 "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex, Bos taurus"
xref: Reactome:REACT_97326 "Transport of Mature Transcript to Cytoplasm, Xenopus tropicalis"
xref: Reactome:REACT_97459 "Transport of Mature mRNAs Derived from Intronless Transcripts, Canis familiaris"
xref: Reactome:REACT_97820 "Release from the NPC and Disassembly of the mRNP, Rattus norvegicus"
xref: Reactome:REACT_98292 "Transport of Mature mRNA derived from an Intron-Containing Transcript, Canis familiaris"
xref: Reactome:REACT_98338 "Transport of Mature mRNA derived from an Intron-Containing Transcript, Drosophila melanogaster"
xref: Reactome:REACT_98481 "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex, Xenopus tropicalis"
xref: Reactome:REACT_99883 "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC, Rattus norvegicus"
is_a: GO:0006405 ! RNA export from nucleus
is_a: GO:0051028 ! mRNA transport
relationship: part_of GO:0010467 ! gene expression
relationship: part_of GO:0071427 ! mRNA-containing ribonucleoprotein complex export from nucleus

[Term]
id: GO:0006407
name: rRNA export from nucleus
namespace: biological_process
def: "The directed movement of rRNA from the nucleus to the cytoplasm; the rRNA is usually in the form of ribonucleoproteins." [GOC:ma, GOC:mah]
synonym: "rRNA export from cell nucleus" EXACT []
synonym: "rRNA export out of nucleus" EXACT []
synonym: "rRNA transport from nucleus to cytoplasm" EXACT []
synonym: "rRNA-nucleus export" EXACT []
is_a: GO:0006405 ! RNA export from nucleus
is_a: GO:0051029 ! rRNA transport
is_a: GO:1902582 ! single-organism intracellular transport
relationship: part_of GO:0042254 ! ribosome biogenesis
relationship: part_of GO:0071428 ! rRNA-containing ribonucleoprotein complex export from nucleus

[Term]
id: GO:0006408
name: snRNA export from nucleus
namespace: biological_process
def: "The directed movement of snRNA from the nucleus to the cytoplasm." [GOC:ma]
synonym: "snRNA export from cell nucleus" EXACT []
synonym: "snRNA export out of nucleus" EXACT []
synonym: "snRNA transport from nucleus to cytoplasm" EXACT []
synonym: "snRNA-nucleus export" EXACT []
is_a: GO:0006405 ! RNA export from nucleus
is_a: GO:0051030 ! snRNA transport
is_a: GO:1902582 ! single-organism intracellular transport

[Term]
id: GO:0006409
name: tRNA export from nucleus
namespace: biological_process
def: "The directed movement of tRNA from the nucleus to the cytoplasm." [GOC:ma]
synonym: "tRNA export from cell nucleus" EXACT []
synonym: "tRNA export out of nucleus" EXACT []
synonym: "tRNA transport from nucleus to cytoplasm" EXACT []
synonym: "tRNA-nucleus export" EXACT []
is_a: GO:0006405 ! RNA export from nucleus
is_a: GO:0051031 ! tRNA transport
is_a: GO:1902582 ! single-organism intracellular transport
relationship: part_of GO:0071431 ! tRNA-containing ribonucleoprotein complex export from nucleus

[Term]
id: GO:0006410
name: obsolete transcription, RNA-dependent
namespace: biological_process
def: "OBSOLETE: The cellular synthesis of DNA on a template of RNA." [GOC:jl]
comment: This term was obsoleted because the name and the definition mean two completely different things: 1) "transcription, RNA-dependent", i.e. RNA-dependent production of an RNA transcript and 2) "reverse transcription", i.e. RNA-dependent DNA synthesis.
synonym: "transcription, RNA-dependent" EXACT []
is_obsolete: true

[Term]
id: GO:0006412
name: translation
namespace: biological_process
alt_id: GO:0006416
alt_id: GO:0006453
alt_id: GO:0043037
def: "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "protein anabolism" EXACT []
synonym: "protein biosynthesis" EXACT []
synonym: "protein biosynthetic process" EXACT [GOC:curators]
synonym: "protein formation" EXACT []
synonym: "protein synthesis" EXACT []
synonym: "protein translation" EXACT []
xref: Reactome:REACT_100338 "Translation, Sus scrofa"
xref: Reactome:REACT_100851 "Translation, Saccharomyces cerevisiae"
xref: Reactome:REACT_101045 "Translation, Dictyostelium discoideum"
xref: Reactome:REACT_101324 "Translation, Canis familiaris"
xref: Reactome:REACT_1014 "Translation, Homo sapiens"
xref: Reactome:REACT_103420 "Translation, Plasmodium falciparum"
xref: Reactome:REACT_105544 "Translation, Arabidopsis thaliana"
xref: Reactome:REACT_29980 "Translation, Bos taurus"
xref: Reactome:REACT_33559 "Translation, Rattus norvegicus"
xref: Reactome:REACT_77710 "Translation, Drosophila melanogaster"
xref: Reactome:REACT_79784 "Translation, Danio rerio"
xref: Reactome:REACT_81734 "Translation, Schizosaccharomyces pombe"
xref: Reactome:REACT_81833 "Translation, Caenorhabditis elegans"
xref: Reactome:REACT_82171 "Translation, Xenopus tropicalis"
xref: Reactome:REACT_83429 "Translation, Taeniopygia guttata"
xref: Reactome:REACT_83530 "Translation, Gallus gallus"
xref: Reactome:REACT_86996 "Translation, Oryza sativa"
xref: Reactome:REACT_95535 "Translation, Mus musculus"
xref: Reactome:REACT_96394 "Translation, Escherichia coli"
xref: Wikipedia:Translation_(genetics)
is_a: GO:0034645 ! cellular macromolecule biosynthetic process
is_a: GO:0043043 ! peptide biosynthetic process
is_a: GO:0044267 ! cellular protein metabolic process
relationship: has_part GO:0006414 ! translational elongation
relationship: part_of GO:0010467 ! gene expression

[Term]
id: GO:0006413
name: translational initiation
namespace: biological_process
alt_id: GO:0006440
alt_id: GO:0006454
def: "The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]
subset: goslim_yeast
subset: gosubset_prok
synonym: "biopolymerisation" BROAD []
synonym: "biopolymerization" BROAD []
synonym: "protein synthesis initiation" BROAD []
synonym: "translation initiation" EXACT []
xref: Reactome:REACT_101789 "Eukaryotic Translation Initiation, Gallus gallus"
xref: Reactome:REACT_104290 "Eukaryotic Translation Initiation, Xenopus tropicalis"
xref: Reactome:REACT_2159 "Eukaryotic Translation Initiation, Homo sapiens"
xref: Reactome:REACT_29447 "Eukaryotic Translation Initiation, Dictyostelium discoideum"
xref: Reactome:REACT_30389 "Eukaryotic Translation Initiation, Oryza sativa"
xref: Reactome:REACT_33969 "Eukaryotic Translation Initiation, Caenorhabditis elegans"
xref: Reactome:REACT_34354 "Eukaryotic Translation Initiation, Taeniopygia guttata"
xref: Reactome:REACT_77252 "Eukaryotic Translation Initiation, Drosophila melanogaster"
xref: Reactome:REACT_79705 "Eukaryotic Translation Initiation, Rattus norvegicus"
xref: Reactome:REACT_85780 "Eukaryotic Translation Initiation, Bos taurus"
xref: Reactome:REACT_88031 "Eukaryotic Translation Initiation, Schizosaccharomyces pombe"
xref: Reactome:REACT_91066 "Eukaryotic Translation Initiation, Arabidopsis thaliana"
xref: Reactome:REACT_95293 "Eukaryotic Translation Initiation, Plasmodium falciparum"
xref: Reactome:REACT_95552 "Eukaryotic Translation Initiation, Mus musculus"
xref: Reactome:REACT_95685 "Eukaryotic Translation Initiation, Canis familiaris"
xref: Reactome:REACT_97707 "Eukaryotic Translation Initiation, Sus scrofa"
xref: Reactome:REACT_98138 "Eukaryotic Translation Initiation, Saccharomyces cerevisiae"
xref: Reactome:REACT_99004 "Eukaryotic Translation Initiation, Danio rerio"
is_a: GO:0044237 ! cellular metabolic process
relationship: part_of GO:0006412 ! translation

[Term]
id: GO:0006414
name: translational elongation
namespace: biological_process
alt_id: GO:0006442
alt_id: GO:0006455
def: "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems]
subset: goslim_yeast
subset: gosubset_prok
synonym: "protein synthesis elongation" BROAD []
synonym: "translation elongation" EXACT []
xref: Reactome:REACT_100207 "Eukaryotic Translation Elongation, Dictyostelium discoideum"
xref: Reactome:REACT_100561 "Eukaryotic Translation Elongation, Canis familiaris"
xref: Reactome:REACT_101290 "Eukaryotic Translation Elongation, Gallus gallus"
xref: Reactome:REACT_101737 "Eukaryotic Translation Elongation, Escherichia coli"
xref: Reactome:REACT_102082 "Eukaryotic Translation Elongation, Mus musculus"
xref: Reactome:REACT_103580 "Eukaryotic Translation Elongation, Danio rerio"
xref: Reactome:REACT_108124 "Eukaryotic Translation Elongation, Xenopus tropicalis"
xref: Reactome:REACT_108677 "Eukaryotic Translation Elongation, Taeniopygia guttata"
xref: Reactome:REACT_108858 "Eukaryotic Translation Elongation, Caenorhabditis elegans"
xref: Reactome:REACT_1477 "Eukaryotic Translation Elongation, Homo sapiens"
xref: Reactome:REACT_30678 "Eukaryotic Translation Elongation, Arabidopsis thaliana"
xref: Reactome:REACT_31079 "Eukaryotic Translation Elongation, Sus scrofa"
xref: Reactome:REACT_80015 "Eukaryotic Translation Elongation, Bos taurus"
xref: Reactome:REACT_80831 "Eukaryotic Translation Elongation, Rattus norvegicus"
xref: Reactome:REACT_81624 "Eukaryotic Translation Elongation, Drosophila melanogaster"
xref: Reactome:REACT_82124 "Eukaryotic Translation Elongation, Saccharomyces cerevisiae"
xref: Reactome:REACT_88049 "Eukaryotic Translation Elongation, Schizosaccharomyces pombe"
xref: Reactome:REACT_93503 "Eukaryotic Translation Elongation, Oryza sativa"
xref: Reactome:REACT_96070 "Eukaryotic Translation Elongation, Plasmodium falciparum"
is_a: GO:0034645 ! cellular macromolecule biosynthetic process
relationship: part_of GO:0006412 ! translation

[Term]
id: GO:0006415
name: translational termination
namespace: biological_process
alt_id: GO:0006443
alt_id: GO:0006456
def: "The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code)." [GOC:hjd, ISBN:019879276X]
subset: gosubset_prok
synonym: "protein synthesis termination" BROAD []
synonym: "translation termination" EXACT []
synonym: "translational complex disassembly" EXACT []
xref: Reactome:REACT_100227 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex, Taeniopygia guttata"
xref: Reactome:REACT_100585 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex, Dictyostelium discoideum"
xref: Reactome:REACT_100730 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex, Danio rerio"
xref: Reactome:REACT_1034 "Eukaryotic Translation Termination, Saccharomyces cerevisiae"
xref: Reactome:REACT_103749 "Eukaryotic Translation Termination, Oryza sativa"
xref: Reactome:REACT_104420 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex, Caenorhabditis elegans"
xref: Reactome:REACT_104616 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex, Taeniopygia guttata"
xref: Reactome:REACT_106326 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex, Plasmodium falciparum"
xref: Reactome:REACT_107138 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex, Schizosaccharomyces pombe"
xref: Reactome:REACT_107171 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex, Danio rerio"
xref: Reactome:REACT_107771 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex, Oryza sativa"
xref: Reactome:REACT_107964 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex, Schizosaccharomyces pombe"
xref: Reactome:REACT_109127 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex, Caenorhabditis elegans"
xref: Reactome:REACT_109494 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex, Plasmodium falciparum"
xref: Reactome:REACT_110009 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex, Mus musculus"
xref: Reactome:REACT_112381 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex, Gallus gallus"
xref: Reactome:REACT_112559 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex, Rattus norvegicus"
xref: Reactome:REACT_112632 "Eukaryotic Translation Termination, Rattus norvegicus"
xref: Reactome:REACT_113540 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex, Gallus gallus"
xref: Reactome:REACT_114287 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex, Gallus gallus"
xref: Reactome:REACT_114807 "Eukaryotic Translation Termination, Gallus gallus"
xref: Reactome:REACT_1152 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex, Saccharomyces cerevisiae"
xref: Reactome:REACT_115292 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex, Rattus norvegicus"
xref: Reactome:REACT_1654 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex, Homo sapiens"
xref: Reactome:REACT_1986 "Eukaryotic Translation Termination, Homo sapiens"
xref: Reactome:REACT_227 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex, Homo sapiens"
xref: Reactome:REACT_28115 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex, Canis familiaris"
xref: Reactome:REACT_28238 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex, Xenopus tropicalis"
xref: Reactome:REACT_28773 "Eukaryotic Translation Termination, Danio rerio"
xref: Reactome:REACT_29257 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex, Drosophila melanogaster"
xref: Reactome:REACT_31194 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex, Canis familiaris"
xref: Reactome:REACT_31222 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex, Oryza sativa"
xref: Reactome:REACT_32804 "Eukaryotic Translation Termination, Drosophila melanogaster"
xref: Reactome:REACT_33545 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex, Dictyostelium discoideum"
xref: Reactome:REACT_34123 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex, Mus musculus"
xref: Reactome:REACT_34462 "Eukaryotic Translation Termination, Saccharomyces cerevisiae"
xref: Reactome:REACT_389 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex, Homo sapiens"
xref: Reactome:REACT_393 "GTP bound eRF3:eRF1 complex binds the peptidyl-tRNA:mRNA:Ribosome complex, Saccharomyces cerevisiae"
xref: Reactome:REACT_716 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex, Saccharomyces cerevisiae"
xref: Reactome:REACT_78279 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex, Arabidopsis thaliana"
xref: Reactome:REACT_78389 "Eukaryotic Translation Termination, Schizosaccharomyces pombe"
xref: Reactome:REACT_78823 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex, Dictyostelium discoideum"
xref: Reactome:REACT_80339 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex, Xenopus tropicalis"
xref: Reactome:REACT_81067 "Eukaryotic Translation Termination, Canis familiaris"
xref: Reactome:REACT_81196 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex, Arabidopsis thaliana"
xref: Reactome:REACT_81882 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex, Caenorhabditis elegans"
xref: Reactome:REACT_83324 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex, Xenopus tropicalis"
xref: Reactome:REACT_83432 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex, Drosophila melanogaster"
xref: Reactome:REACT_84537 "Eukaryotic Translation Termination, Plasmodium falciparum"
xref: Reactome:REACT_84840 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex, Plasmodium falciparum"
xref: Reactome:REACT_84975 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex, Arabidopsis thaliana"
xref: Reactome:REACT_86647 "Eukaryotic Translation Termination, Xenopus tropicalis"
xref: Reactome:REACT_86888 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex, Taeniopygia guttata"
xref: Reactome:REACT_87882 "Eukaryotic Translation Termination, Dictyostelium discoideum"
xref: Reactome:REACT_88395 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex, Canis familiaris"
xref: Reactome:REACT_88662 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex, Danio rerio"
xref: Reactome:REACT_91109 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex, Oryza sativa"
xref: Reactome:REACT_92456 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex, Schizosaccharomyces pombe"
xref: Reactome:REACT_92895 "Eukaryotic Translation Termination, Taeniopygia guttata"
xref: Reactome:REACT_93205 "Eukaryotic Translation Termination, Caenorhabditis elegans"
xref: Reactome:REACT_93556 "Eukaryotic Translation Termination, Mus musculus"
xref: Reactome:REACT_94459 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex, Drosophila melanogaster"
xref: Reactome:REACT_94463 "Eukaryotic Translation Termination, Arabidopsis thaliana"
xref: Reactome:REACT_97483 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex, Mus musculus"
is_a: GO:0043624 ! cellular protein complex disassembly
relationship: part_of GO:0006412 ! translation

[Term]
id: GO:0006417
name: regulation of translation
namespace: biological_process
alt_id: GO:0006445
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:isa_complete]
subset: goslim_yeast
subset: gosubset_prok
synonym: "regulation of protein anabolism" EXACT []
synonym: "regulation of protein biosynthesis" EXACT []
synonym: "regulation of protein formation" EXACT []
synonym: "regulation of protein synthesis" EXACT []
is_a: GO:0010608 ! posttranscriptional regulation of gene expression
is_a: GO:0032268 ! regulation of cellular protein metabolic process
is_a: GO:0034248 ! regulation of cellular amide metabolic process
is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006412 ! translation
relationship: regulates GO:0006412 ! translation

[Term]
id: GO:0006418
name: tRNA aminoacylation for protein translation
namespace: biological_process
def: "The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]
subset: goslim_yeast
subset: gosubset_prok
synonym: "tRNA charging" NARROW []
xref: MetaCyc:TRNA-CHARGING-PWY
xref: Reactome:REACT_100041 "Mitochondrial tRNA aminoacylation, Escherichia coli"
xref: Reactome:REACT_100416 "Cytosolic tRNA aminoacylation, Sus scrofa"
xref: Reactome:REACT_100487 "Mitochondrial tRNA aminoacylation, Drosophila melanogaster"
xref: Reactome:REACT_102312 "tRNA Aminoacylation, Plasmodium falciparum"
xref: Reactome:REACT_103116 "tRNA Aminoacylation, Canis familiaris"
xref: Reactome:REACT_103136 "Mitochondrial tRNA aminoacylation, Taeniopygia guttata"
xref: Reactome:REACT_103575 "tRNA Aminoacylation, Arabidopsis thaliana"
xref: Reactome:REACT_103831 "Mitochondrial tRNA aminoacylation, Oryza sativa"
xref: Reactome:REACT_104381 "Cytosolic tRNA aminoacylation, Staphylococcus aureus N315"
xref: Reactome:REACT_106785 "Cytosolic tRNA aminoacylation, Schizosaccharomyces pombe"
xref: Reactome:REACT_107047 "tRNA Aminoacylation, Escherichia coli"
xref: Reactome:REACT_107203 "Cytosolic tRNA aminoacylation, Plasmodium falciparum"
xref: Reactome:REACT_107248 "tRNA Aminoacylation, Danio rerio"
xref: Reactome:REACT_107617 "Mitochondrial tRNA aminoacylation, Rattus norvegicus"
xref: Reactome:REACT_107708 "tRNA Aminoacylation, Schizosaccharomyces pombe"
xref: Reactome:REACT_109699 "tRNA Aminoacylation, Xenopus tropicalis"
xref: Reactome:REACT_111025 "Cytosolic tRNA aminoacylation, Caenorhabditis elegans"
xref: Reactome:REACT_15302 "Mitochondrial tRNA aminoacylation, Homo sapiens"
xref: Reactome:REACT_15306 "Cytosolic tRNA aminoacylation, Homo sapiens"
xref: Reactome:REACT_15482 "tRNA Aminoacylation, Homo sapiens"
xref: Reactome:REACT_28311 "tRNA Aminoacylation, Staphylococcus aureus N315"
xref: Reactome:REACT_28868 "tRNA Aminoacylation, Bos taurus"
xref: Reactome:REACT_29481 "tRNA Aminoacylation, Mycobacterium tuberculosis"
xref: Reactome:REACT_30365 "Cytosolic tRNA aminoacylation, Dictyostelium discoideum"
xref: Reactome:REACT_31574 "Cytosolic tRNA aminoacylation, Oryza sativa"
xref: Reactome:REACT_31839 "Cytosolic tRNA aminoacylation, Bos taurus"
xref: Reactome:REACT_33855 "tRNA Aminoacylation, Caenorhabditis elegans"
xref: Reactome:REACT_34656 "Mitochondrial tRNA aminoacylation, Caenorhabditis elegans"
xref: Reactome:REACT_40380 "tRNA Aminoacylation, Rattus norvegicus"
xref: Reactome:REACT_59282 "Cytosolic tRNA aminoacylation, Mus musculus"
xref: Reactome:REACT_78082 "tRNA Aminoacylation, Mus musculus"
xref: Reactome:REACT_79804 "Mitochondrial tRNA aminoacylation, Dictyostelium discoideum"
xref: Reactome:REACT_80723 "tRNA Aminoacylation, Drosophila melanogaster"
xref: Reactome:REACT_81425 "tRNA Aminoacylation, Sus scrofa"
xref: Reactome:REACT_81996 "Mitochondrial tRNA aminoacylation, Saccharomyces cerevisiae"
xref: Reactome:REACT_82393 "Cytosolic tRNA aminoacylation, Escherichia coli"
xref: Reactome:REACT_82791 "Cytosolic tRNA aminoacylation, Danio rerio"
xref: Reactome:REACT_84562 "Mitochondrial tRNA aminoacylation, Bos taurus"
xref: Reactome:REACT_84847 "Cytosolic tRNA aminoacylation, Xenopus tropicalis"
xref: Reactome:REACT_85758 "tRNA Aminoacylation, Taeniopygia guttata"
xref: Reactome:REACT_85924 "Cytosolic tRNA aminoacylation, Taeniopygia guttata"
xref: Reactome:REACT_86341 "Mitochondrial tRNA aminoacylation, Mycobacterium tuberculosis"
xref: Reactome:REACT_87556 "Cytosolic tRNA aminoacylation, Drosophila melanogaster"
xref: Reactome:REACT_88061 "Cytosolic tRNA aminoacylation, Rattus norvegicus"
xref: Reactome:REACT_88111 "Mitochondrial tRNA aminoacylation, Arabidopsis thaliana"
xref: Reactome:REACT_88297 "Cytosolic tRNA aminoacylation, Gallus gallus"
xref: Reactome:REACT_89110 "Cytosolic tRNA aminoacylation, Canis familiaris"
xref: Reactome:REACT_89459 "tRNA Aminoacylation, Oryza sativa"
xref: Reactome:REACT_89892 "Mitochondrial tRNA aminoacylation, Xenopus tropicalis"
xref: Reactome:REACT_91438 "Mitochondrial tRNA aminoacylation, Staphylococcus aureus N315"
xref: Reactome:REACT_91939 "Mitochondrial tRNA aminoacylation, Mus musculus"
xref: Reactome:REACT_93083 "Mitochondrial tRNA aminoacylation, Danio rerio"
xref: Reactome:REACT_93096 "tRNA Aminoacylation, Gallus gallus"
xref: Reactome:REACT_93590 "Cytosolic tRNA aminoacylation, Saccharomyces cerevisiae"
xref: Reactome:REACT_95057 "Cytosolic tRNA aminoacylation, Mycobacterium tuberculosis"
xref: Reactome:REACT_95362 "Mitochondrial tRNA aminoacylation, Plasmodium falciparum"
xref: Reactome:REACT_95636 "Mitochondrial tRNA aminoacylation, Gallus gallus"
xref: Reactome:REACT_95656 "tRNA Aminoacylation, Dictyostelium discoideum"
xref: Reactome:REACT_97943 "Mitochondrial tRNA aminoacylation, Sus scrofa"
xref: Reactome:REACT_98561 "Mitochondrial tRNA aminoacylation, Schizosaccharomyces pombe"
xref: Reactome:REACT_98686 "Cytosolic tRNA aminoacylation, Arabidopsis thaliana"
xref: Reactome:REACT_99090 "tRNA Aminoacylation, Saccharomyces cerevisiae"
xref: Reactome:REACT_99901 "Mitochondrial tRNA aminoacylation, Canis familiaris"
is_a: GO:0043039 ! tRNA aminoacylation
relationship: part_of GO:0006412 ! translation

[Term]
id: GO:0006419
name: alanyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
subset: gosubset_prok
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006420
name: arginyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling arginine to arginyl-tRNA, catalyzed by arginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
subset: gosubset_prok
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006421
name: asparaginyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling asparagine to asparaginyl-tRNA, catalyzed by asparaginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
subset: gosubset_prok
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006422
name: aspartyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, ISBN:0716730510]
subset: gosubset_prok
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006423
name: cysteinyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
subset: gosubset_prok
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006424
name: glutamyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling glutamate to glutamyl-tRNA, catalyzed by glutamyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'- adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
subset: gosubset_prok
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006425
name: glutaminyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling glutamine to glutaminyl-tRNA, catalyzed by glutaminyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'- adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
subset: gosubset_prok
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006426
name: glycyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling glycine to glycyl-tRNA, catalyzed by glycyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
subset: gosubset_prok
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006427
name: histidyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
subset: gosubset_prok
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006428
name: isoleucyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
subset: gosubset_prok
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006429
name: leucyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
subset: gosubset_prok
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006430
name: lysyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
subset: gosubset_prok
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006431
name: methionyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
subset: gosubset_prok
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006432
name: phenylalanyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
subset: gosubset_prok
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006433
name: prolyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, ISBN:0716730510]
subset: gosubset_prok
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006434
name: seryl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
subset: gosubset_prok
is_a: GO:0006418 ! tRNA aminoacylation for protein translation
relationship: has_part GO:0097056 ! selenocysteinyl-tRNA(Sec) biosynthetic process

[Term]
id: GO:0006435
name: threonyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
subset: gosubset_prok
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006436
name: tryptophanyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
subset: gosubset_prok
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006437
name: tyrosyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
subset: gosubset_prok
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006438
name: valyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
subset: gosubset_prok
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006439
name: obsolete aminoacyl-tRNA hydrolase reaction
namespace: biological_process
def: "OBSOLETE. Hydrolysis of the peptidyl-tRNA by aminoacyl-tRNA hydrolase upon termination of translation. Analogous to usual peptidyl transfer during elongation, except that the acceptor is H2O instead of an aminoacyl-tRNA." [ISBN:019879276X]
comment: This term was made obsolete because it represents a molecular function.
synonym: "aminoacyl-tRNA hydrolase reaction" EXACT []
is_obsolete: true
replaced_by: GO:0004045

[Term]
id: GO:0006441
name: obsolete binding to mRNA cap
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:hjd]
comment: This term was made obsolete because it represents a function rather than a process.
synonym: "binding to mRNA cap" EXACT []
is_obsolete: true
consider: GO:0000339

[Term]
id: GO:0006446
name: regulation of translational initiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of translational initiation." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0006417 ! regulation of translation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006413 ! translational initiation
relationship: regulates GO:0006413 ! translational initiation

[Term]
id: GO:0006447
name: regulation of translational initiation by iron
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the translation of certain mRNAs involved in iron metabolism; regulated by the concentration of iron." [GOC:jl]
subset: gosubset_prok
is_a: GO:0006446 ! regulation of translational initiation

[Term]
id: GO:0006448
name: regulation of translational elongation
namespace: biological_process
def: "Any process that modulates the frequency, rate, extent or accuracy of translational elongation." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0006417 ! regulation of translation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006414 ! translational elongation
relationship: regulates GO:0006414 ! translational elongation

[Term]
id: GO:0006449
name: regulation of translational termination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of translational termination." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0006417 ! regulation of translation
is_a: GO:0043244 ! regulation of protein complex disassembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006415 ! translational termination
relationship: regulates GO:0006415 ! translational termination

[Term]
id: GO:0006450
name: regulation of translational fidelity
namespace: biological_process
alt_id: GO:0000029
def: "Any process that modulates the ability of the translational apparatus to interpret the genetic code." [GOC:dph, GOC:tb]
subset: gosubset_prok
synonym: "regulation of translational accuracy" EXACT []
is_a: GO:0006448 ! regulation of translational elongation
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0006451
name: translational readthrough
namespace: biological_process
def: "The continuation of translation beyond a stop codon by the use of a special tRNA that recognizes the UAG and UGA codons as modified amino acids, rather than as termination codons." [GOC:jsg, PMID:11179232]
subset: gosubset_prok
synonym: "natural nonsense suppression" RELATED []
is_a: GO:0006414 ! translational elongation
is_a: GO:0006417 ! regulation of translation

[Term]
id: GO:0006452
name: translational frameshifting
namespace: biological_process
def: "A mechanism whereby different proteins may result from a single mRNA molecule, due to a change in the parsing of three nucleotides per codon relative to an initiating AUG codon." [GOC:hjd, ISBN:0195094425]
subset: gosubset_prok
xref: Wikipedia:Translational_frameshift
is_a: GO:0006414 ! translational elongation

[Term]
id: GO:0006457
name: protein folding
namespace: biological_process
alt_id: GO:0007022
alt_id: GO:0007024
alt_id: GO:0007025
def: "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_pir
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "alpha-tubulin folding" NARROW [GOC:mah]
synonym: "beta-tubulin folding" NARROW [GOC:mah]
synonym: "chaperone activity" RELATED []
synonym: "chaperonin ATPase activity" RELATED []
synonym: "chaperonin-mediated tubulin folding" NARROW [GOC:mah]
synonym: "co-chaperone activity" RELATED []
synonym: "co-chaperonin activity" RELATED []
synonym: "glycoprotein-specific chaperone activity" RELATED []
synonym: "non-chaperonin molecular chaperone ATPase activity" RELATED []
synonym: "protein complex assembly, multichaperone pathway" RELATED []
xref: Reactome:REACT_100411 "Chaperonin-mediated protein folding, Arabidopsis thaliana"
xref: Reactome:REACT_104912 "Chaperonin-mediated protein folding, Caenorhabditis elegans"
xref: Reactome:REACT_105663 "Chaperonin-mediated protein folding, Rattus norvegicus"
xref: Reactome:REACT_106009 "Chaperonin-mediated protein folding, Canis familiaris"
xref: Reactome:REACT_106427 "Chaperonin-mediated protein folding, Mus musculus"
xref: Reactome:REACT_106894 "Formation of tubulin folding intermediates by CCT/TriC, Canis familiaris"
xref: Reactome:REACT_106927 "Chaperonin-mediated protein folding, Drosophila melanogaster"
xref: Reactome:REACT_107029 "Formation of tubulin folding intermediates by CCT/TriC, Drosophila melanogaster"
xref: Reactome:REACT_108248 "Chaperonin-mediated protein folding, Gallus gallus"
xref: Reactome:REACT_109411 "Formation of tubulin folding intermediates by CCT/TriC, Bos taurus"
xref: Reactome:REACT_110417 "Formation of tubulin folding intermediates by CCT/TriC, Rattus norvegicus"
xref: Reactome:REACT_16956 "Formation of tubulin folding intermediates by CCT/TriC, Homo sapiens"
xref: Reactome:REACT_17001 "Formation of tubulin folding intermediates by CCT/TriC, Mus musculus"
xref: Reactome:REACT_17004 "Chaperonin-mediated protein folding, Homo sapiens"
xref: Reactome:REACT_17056 "Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding, Bos taurus"
xref: Reactome:REACT_23878 "N-glycan trimming in the ER and Calnexin/Calreticulin cycle, Homo sapiens"
xref: Reactome:REACT_30906 "Chaperonin-mediated protein folding, Oryza sativa"
xref: Reactome:REACT_32155 "Chaperonin-mediated protein folding, Saccharomyces cerevisiae"
xref: Reactome:REACT_32255 "Chaperonin-mediated protein folding, Schizosaccharomyces pombe"
xref: Reactome:REACT_33395 "Formation of tubulin folding intermediates by CCT/TriC, Mus musculus"
xref: Reactome:REACT_77627 "Chaperonin-mediated protein folding, Plasmodium falciparum"
xref: Reactome:REACT_77963 "Formation of tubulin folding intermediates by CCT/TriC, Saccharomyces cerevisiae"
xref: Reactome:REACT_78530 "Formation of tubulin folding intermediates by CCT/TriC, Gallus gallus"
xref: Reactome:REACT_81155 "Formation of tubulin folding intermediates by CCT/TriC, Caenorhabditis elegans"
xref: Reactome:REACT_83906 "Chaperonin-mediated protein folding, Dictyostelium discoideum"
xref: Reactome:REACT_85492 "Formation of tubulin folding intermediates by CCT/TriC, Sus scrofa"
xref: Reactome:REACT_85496 "Formation of tubulin folding intermediates by CCT/TriC, Plasmodium falciparum"
xref: Reactome:REACT_86318 "Formation of tubulin folding intermediates by CCT/TriC, Arabidopsis thaliana"
xref: Reactome:REACT_91676 "Formation of tubulin folding intermediates by CCT/TriC, Schizosaccharomyces pombe"
xref: Reactome:REACT_92785 "Formation of tubulin folding intermediates by CCT/TriC, Dictyostelium discoideum"
xref: Reactome:REACT_92961 "Chaperonin-mediated protein folding, Xenopus tropicalis"
xref: Reactome:REACT_92981 "Chaperonin-mediated protein folding, Taeniopygia guttata"
xref: Reactome:REACT_94123 "Formation of tubulin folding intermediates by CCT/TriC, Taeniopygia guttata"
xref: Reactome:REACT_94443 "Formation of tubulin folding intermediates by CCT/TriC, Danio rerio"
xref: Reactome:REACT_94772 "Chaperonin-mediated protein folding, Sus scrofa"
xref: Reactome:REACT_96773 "Chaperonin-mediated protein folding, Danio rerio"
xref: Reactome:REACT_97016 "Chaperonin-mediated protein folding, Bos taurus"
xref: Reactome:REACT_97220 "Formation of tubulin folding intermediates by CCT/TriC, Xenopus tropicalis"
xref: Reactome:REACT_98132 "Formation of tubulin folding intermediates by CCT/TriC, Oryza sativa"
xref: Wikipedia:Protein_folding
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0006458
name: 'de novo' protein folding
namespace: biological_process
def: "The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure." [GOC:mb]
subset: gosubset_prok
synonym: "nascent chain protein folding" EXACT []
is_a: GO:0006457 ! protein folding

[Term]
id: GO:0006459
name: obsolete binding unfolded ER proteins
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a function rather than a process.
synonym: "binding unfolded ER proteins" EXACT []
is_obsolete: true
consider: GO:0005783
consider: GO:0051082

[Term]
id: GO:0006460
name: obsolete peptidyl-prolyl isomerase B reaction
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a molecular function and not a biological process.
synonym: "peptidyl-prolyl isomerase B reaction" EXACT []
is_obsolete: true
consider: GO:0003755

[Term]
id: GO:0006461
name: protein complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a protein complex." [GOC:ai]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_pombe
subset: gosubset_prok
synonym: "chaperone activity" RELATED []
synonym: "protein complex formation" EXACT []
is_a: GO:0065003 ! macromolecular complex assembly
is_a: GO:0071822 ! protein complex subunit organization
relationship: part_of GO:0070271 ! protein complex biogenesis

[Term]
id: GO:0006462
name: obsolete protein complex assembly, multichaperone pathway
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because the string was ambiguous and the original meaning of the term was hence unknown.
synonym: "protein complex assembly, multichaperone pathway" EXACT []
is_obsolete: true
consider: GO:0006457
consider: GO:0051131

[Term]
id: GO:0006463
name: steroid hormone receptor complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a steroid hormone receptor complex, an intracellular receptor that binds steroid hormones. The complex is often a dimer, and forms after the steroid has bound the receptor." [GOC:jl, Wikipedia:Steroid_hormone_receptor]
is_a: GO:0043623 ! cellular protein complex assembly

[Term]
id: GO:0006464
name: cellular protein modification process
namespace: biological_process
def: "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "process resulting in protein modification" RELATED []
synonym: "protein modification process" BROAD [GOC:bf, GOC:jl]
synonym: "protein tagging activity" RELATED []
is_a: GO:0036211 ! protein modification process
is_a: GO:0044267 ! cellular protein metabolic process

[Term]
id: GO:0006465
name: signal peptide processing
namespace: biological_process
def: "The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell." [GOC:mah, ISBN:0815316194]
subset: gosubset_prok
synonym: "leader peptide processing" EXACT []
is_a: GO:0006518 ! peptide metabolic process
is_a: GO:0016485 ! protein processing
is_a: GO:0044267 ! cellular protein metabolic process

[Term]
id: GO:0006466
name: obsolete protein disulfide-isomerase reaction
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it presents a molecular function.
synonym: "protein disulfide-isomerase reaction" EXACT []
synonym: "protein disulphide-isomerase reaction" EXACT []
is_obsolete: true
replaced_by: GO:0003756

[Term]
id: GO:0006468
name: protein phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group on to a protein." [GOC:hb]
subset: goslim_yeast
subset: gosubset_prok
synonym: "protein amino acid phosphorylation" EXACT [GOC:bf]
is_a: GO:0006464 ! cellular protein modification process
is_a: GO:0016310 ! phosphorylation

[Term]
id: GO:0006469
name: negative regulation of protein kinase activity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of protein kinase activity" EXACT []
synonym: "down-regulation of protein kinase activity" EXACT []
synonym: "downregulation of protein kinase activity" EXACT []
synonym: "inhibition of protein kinase activity" NARROW []
is_a: GO:0001933 ! negative regulation of protein phosphorylation
is_a: GO:0033673 ! negative regulation of kinase activity
is_a: GO:0045859 ! regulation of protein kinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004672 ! protein kinase activity
relationship: negatively_regulates GO:0004672 ! protein kinase activity

[Term]
id: GO:0006470
name: protein dephosphorylation
namespace: biological_process
def: "The process of removing one or more phosphoric residues from a protein." [GOC:hb]
subset: goslim_yeast
subset: gosubset_prok
synonym: "protein amino acid dephosphorylation" EXACT [GOC:bf]
is_a: GO:0006464 ! cellular protein modification process
is_a: GO:0016311 ! dephosphorylation

[Term]
id: GO:0006471
name: protein ADP-ribosylation
namespace: biological_process
def: "The transfer, from NAD, of ADP-ribose to protein amino acids." [GOC:pr, RESID:AA0040, RESID:AA0168, RESID:AA0169, RESID:AA0231, RESID:AA0237, RESID:AA0295]
subset: gosubset_prok
synonym: "protein amino acid ADP-ribosylation" EXACT [GOC:bf]
xref: Reactome:REACT_115620 "ADP-Ribosylation of HNP-1, Homo sapiens"
xref: RESID:AA0040
xref: RESID:AA0168
xref: RESID:AA0169
xref: RESID:AA0231
xref: RESID:AA0237
xref: RESID:AA0295
is_a: GO:0006486 ! protein glycosylation

[Term]
id: GO:0006473
name: protein acetylation
namespace: biological_process
def: "The addition of an acetyl group to a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai]
subset: gosubset_prok
synonym: "protein amino acid acetylation" EXACT [GOC:bf]
is_a: GO:0043543 ! protein acylation

[Term]
id: GO:0006474
name: N-terminal protein amino acid acetylation
namespace: biological_process
def: "The acetylation of the N-terminal amino acid of proteins." [GOC:ai]
subset: gosubset_prok
synonym: "N(alpha)-terminal acetylation" NARROW [PMID:11013267]
is_a: GO:0006473 ! protein acetylation
is_a: GO:0031365 ! N-terminal protein amino acid modification

[Term]
id: GO:0006475
name: internal protein amino acid acetylation
namespace: biological_process
def: "The addition of an acetyl group to a non-terminal amino acid in a protein." [GOC:mah]
subset: gosubset_prok
is_a: GO:0006473 ! protein acetylation

[Term]
id: GO:0006476
name: protein deacetylation
namespace: biological_process
def: "The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai]
subset: gosubset_prok
synonym: "protein amino acid deacetylation" EXACT [GOC:bf]
is_a: GO:0035601 ! protein deacylation

[Term]
id: GO:0006477
name: protein sulfation
namespace: biological_process
def: "The addition of a sulfate group as an ester to a protein amino acid." [GOC:curators]
subset: gosubset_prok
synonym: "protein amino acid sulfation" EXACT [GOC:bf]
synonym: "protein amino acid sulphation" EXACT []
is_a: GO:0006464 ! cellular protein modification process
is_a: GO:0051923 ! sulfation

[Term]
id: GO:0006478
name: peptidyl-tyrosine sulfation
namespace: biological_process
def: "The sulfation of peptidyl-tyrosine residues to form peptidyl-O4'-sulfo-L-tyrosine." [RESID:AA0172]
subset: gosubset_prok
synonym: "peptidyl-tyrosine sulphation" EXACT []
xref: RESID:AA0172
is_a: GO:0006477 ! protein sulfation
is_a: GO:0018212 ! peptidyl-tyrosine modification

[Term]
id: GO:0006479
name: protein methylation
namespace: biological_process
def: "The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom." [GOC:ai]
subset: gosubset_prok
synonym: "protein amino acid methylation" EXACT [GOC:bf]
is_a: GO:0008213 ! protein alkylation
is_a: GO:0043414 ! macromolecule methylation

[Term]
id: GO:0006480
name: N-terminal protein amino acid methylation
namespace: biological_process
def: "The methylation of the N-terminal amino acid of a protein." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006479 ! protein methylation
is_a: GO:0031365 ! N-terminal protein amino acid modification

[Term]
id: GO:0006481
name: C-terminal protein methylation
namespace: biological_process
def: "The methylation of the C-terminal amino acid of a protein." [GOC:ai]
subset: gosubset_prok
synonym: "C-terminal protein amino acid methylation" EXACT [GOC:bf]
is_a: GO:0006479 ! protein methylation
is_a: GO:0018410 ! C-terminal protein amino acid modification

[Term]
id: GO:0006482
name: protein demethylation
namespace: biological_process
def: "The removal of a methyl group, from a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom." [GOC:mah]
subset: gosubset_prok
synonym: "protein amino acid demethylation" EXACT [GOC:bf]
is_a: GO:0008214 ! protein dealkylation
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0070988 ! demethylation

[Term]
id: GO:0006483
name: obsolete peptidyl-aspartic acid/asparagine hydroxylation
namespace: biological_process
def: "OBSOLETE. The hydroxylation of peptidyl-aspartic acid or asparagine." [GOC:ai]
comment: This term was made obsolete because it is a redundant grouping term.
synonym: "aspartic acid/asparagine hydroxylation" EXACT []
synonym: "peptidyl-aspartic acid/asparagine hydroxylation" EXACT []
is_obsolete: true
consider: GO:0042264
consider: GO:0042265

[Term]
id: GO:0006484
name: obsolete protein cysteine-thiol oxidation
namespace: biological_process
def: "OBSOLETE. Oxidation of two cysteine sulfhydryl groups (thiols) in one protein by a disulfide bond in a second protein to form a disulfide bond in the first protein and two reduced sulfhydryls in the second. The oxidized cysteines linked by a disulfide bond is known as cystine." [http://micro.magnet.fsu.edu/aminoacids/pages/cystine.html, http://www.indstate.edu/thcme/mwking/pentose-phosphate-pathway.html, RESID:AA0025]
comment: This term was made obsolete because it represents a single activity.
synonym: "protein cysteine-thiol oxidation" EXACT []
is_obsolete: true
consider: GO:0003756

[Term]
id: GO:0006486
name: protein glycosylation
namespace: biological_process
def: "A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "protein amino acid glycosylation" EXACT [GOC:bf]
is_a: GO:0006464 ! cellular protein modification process
is_a: GO:0043413 ! macromolecule glycosylation
is_a: GO:0044763 ! single-organism cellular process
relationship: part_of GO:0009101 ! glycoprotein biosynthetic process

[Term]
id: GO:0006487
name: protein N-linked glycosylation
namespace: biological_process
def: "A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327]
subset: gosubset_prok
synonym: "N-glycan biosynthesis" RELATED []
synonym: "N-glycan metabolism" RELATED []
synonym: "protein amino acid N-linked glycosylation" EXACT [GOC:bf]
xref: RESID:AA0151
xref: RESID:AA0156
xref: RESID:AA0327
is_a: GO:0006486 ! protein glycosylation

[Term]
id: GO:0006488
name: dolichol-linked oligosaccharide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dolichol-linked oligosaccharide, usually by a stepwise addition of glycosyl chains to endoplasmic reticulum membrane-bound dolichol-P." [GOC:jl, ISBN:0471331309]
subset: gosubset_prok
synonym: "dolichol-linked oligosaccharide anabolism" EXACT []
synonym: "dolichol-linked oligosaccharide biosynthesis" EXACT []
synonym: "dolichol-linked oligosaccharide formation" EXACT []
synonym: "dolichol-linked oligosaccharide synthesis" EXACT []
synonym: "N-linked glycan precursor biosynthesis" EXACT [PMID:8666161]
synonym: "N-linked glycan precursor biosynthetic process" EXACT [PMID:8666161]
synonym: "oligosaccharide-PP-dolichol assembly" EXACT []
xref: Reactome:REACT_103173 "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Canis familiaris"
xref: Reactome:REACT_104066 "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Xenopus tropicalis"
xref: Reactome:REACT_104983 "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Saccharomyces cerevisiae"
xref: Reactome:REACT_107177 "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Dictyostelium discoideum"
xref: Reactome:REACT_22433 "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Homo sapiens"
xref: Reactome:REACT_30432 "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Caenorhabditis elegans"
xref: Reactome:REACT_31351 "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Drosophila melanogaster"
xref: Reactome:REACT_78377 "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Taeniopygia guttata"
xref: Reactome:REACT_79181 "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Sus scrofa"
xref: Reactome:REACT_81135 "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Arabidopsis thaliana"
xref: Reactome:REACT_81706 "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Mus musculus"
xref: Reactome:REACT_83294 "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Schizosaccharomyces pombe"
xref: Reactome:REACT_83316 "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Oryza sativa"
xref: Reactome:REACT_84088 "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Danio rerio"
xref: Reactome:REACT_90284 "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Gallus gallus"
xref: Reactome:REACT_95313 "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Rattus norvegicus"
xref: Reactome:REACT_99694 "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Bos taurus"
is_a: GO:0006490 ! oligosaccharide-lipid intermediate biosynthetic process

[Term]
id: GO:0006489
name: dolichyl diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dolichyl diphosphate, a diphosphorylated dolichol derivative." [ISBN:0198506732]
synonym: "dolichyl diphosphate anabolism" EXACT []
synonym: "dolichyl diphosphate biosynthesis" EXACT []
synonym: "dolichyl diphosphate formation" EXACT []
synonym: "dolichyl diphosphate synthesis" EXACT []
xref: Reactome:REACT_22230 "Synthesis of Dolichyl-phosphate, Homo sapiens"
is_a: GO:0008654 ! phospholipid biosynthetic process
is_a: GO:0046465 ! dolichyl diphosphate metabolic process
relationship: part_of GO:0006488 ! dolichol-linked oligosaccharide biosynthetic process

[Term]
id: GO:0006490
name: oligosaccharide-lipid intermediate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an oligosaccharide-lipid intermediate, such as a molecule of dolichol-P-man or dolicol-P-Glc used in N-linked glycosylation." [GOC:dph, GOC:hjd, GOC:isa_complete, GOC:pr, GOC:rb]
subset: gosubset_prok
synonym: "oligosaccharide-lipid intermediate assembly" NARROW [GOC:pr]
synonym: "oligosaccharide-lipid intermediate biosynthetic process" NARROW [GOC:pr]
is_a: GO:0044255 ! cellular lipid metabolic process
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process

[Term]
id: GO:0006491
name: N-glycan processing
namespace: biological_process
alt_id: GO:0006492
def: "The conversion of N-linked glycan (N = nitrogen) structures from the initially transferred oligosaccharide to a mature form, by the actions of glycosidases and glycosyltransferases. The early processing steps are conserved and play roles in glycoprotein folding and trafficking." [ISBN:0879695595, PMID:12736198]
subset: gosubset_prok
synonym: "N-glycan catabolism" RELATED []
synonym: "N-glycan degradation" RELATED []
synonym: "N-linked glycoprotein maturation" EXACT []
is_a: GO:0009311 ! oligosaccharide metabolic process
relationship: part_of GO:0006487 ! protein N-linked glycosylation

[Term]
id: GO:0006493
name: protein O-linked glycosylation
namespace: biological_process
def: "A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan." [GOC:pr, ISBN:0879695595, RESID:AA0153, RESID:AA0154, RESID:AA0155, RESID:AA0157, RESID:AA0212]
subset: gosubset_prok
synonym: "protein amino acid O-linked glycosylation" EXACT [GOC:bf]
xref: RESID:AA0153
xref: RESID:AA0154
xref: RESID:AA0155
xref: RESID:AA0157
xref: RESID:AA0212
is_a: GO:0006486 ! protein glycosylation

[Term]
id: GO:0006494
name: obsolete protein amino acid terminal glycosylation
namespace: biological_process
def: "A protein amino acid glycosylation process in which a sugar unit is added to a free alpha-amino or alpha-carboxyl terminal of a peptide." [GOC:jsg]
comment: This term was made obsolete because the term name is ambiguous.
subset: gosubset_prok
synonym: "protein amino acid terminal glycosylation" EXACT []
is_obsolete: true
consider: GO:0006486

[Term]
id: GO:0006495
name: obsolete terminal O-glycosylation
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators, GOC:jsg]
comment: This term was made obsolete because there is no evidence for the existence of this process.
synonym: "terminal O-glycosylation" EXACT []
is_obsolete: true

[Term]
id: GO:0006496
name: obsolete protein amino acid terminal N-glycosylation
namespace: biological_process
def: "The glycosylation of a nitrogen atom of a free alpha amino terminal of a peptide." [GOC:jsg]
comment: This term was made obsolete because the term name is ambiguous.
subset: gosubset_prok
synonym: "protein amino acid terminal N-glycosylation" EXACT []
is_obsolete: true
consider: GO:0006487
consider: GO:0035629

[Term]
id: GO:0006497
name: protein lipidation
namespace: biological_process
alt_id: GO:0042050
def: "The covalent attachment of lipid groups to an amino acid in a protein." [GOC:jl]
comment: For non-covalent interactions with a lipid, consider instead the term 'lipid binding ; GO:0008289' and its children.
subset: goslim_yeast
subset: gosubset_prok
synonym: "lipid:protein modification" EXACT []
synonym: "protein amino acid lipidation" EXACT [GOC:bf]
xref: RESID:AA0059
xref: RESID:AA0060
xref: RESID:AA0077
xref: RESID:AA0078
xref: RESID:AA0079
xref: RESID:AA0080
xref: RESID:AA0102
xref: RESID:AA0103
xref: RESID:AA0104
xref: RESID:AA0106
xref: RESID:AA0107
xref: RESID:AA0158
xref: RESID:AA0159
xref: RESID:AA0160
xref: RESID:AA0161
xref: RESID:AA0162
xref: RESID:AA0163
xref: RESID:AA0166
xref: RESID:AA0223
xref: RESID:AA0290
xref: RESID:AA0307
xref: RESID:AA0308
xref: RESID:AA0309
xref: RESID:AA0316
is_a: GO:0006464 ! cellular protein modification process
relationship: part_of GO:0042158 ! lipoprotein biosynthetic process

[Term]
id: GO:0006498
name: N-terminal protein lipidation
namespace: biological_process
def: "The covalent attachment of a lipid group to the amino terminus of a protein." [GOC:jl]
subset: gosubset_prok
is_a: GO:0006497 ! protein lipidation
is_a: GO:0031365 ! N-terminal protein amino acid modification

[Term]
id: GO:0006499
name: N-terminal protein myristoylation
namespace: biological_process
def: "The covalent attachment of a myristoyl group to the N-terminal amino acid residue of a protein." [GOC:mah]
subset: gosubset_prok
xref: Reactome:REACT_116143 "Myristoylation of Nef, Homo sapiens"
is_a: GO:0006498 ! N-terminal protein lipidation
is_a: GO:0018377 ! protein myristoylation

[Term]
id: GO:0006500
name: N-terminal protein palmitoylation
namespace: biological_process
def: "The covalent attachment of a palmitoyl group to the N-terminal amino acid residue of a protein." [GOC:mah]
subset: gosubset_prok
is_a: GO:0006498 ! N-terminal protein lipidation
is_a: GO:0018345 ! protein palmitoylation

[Term]
id: GO:0006501
name: C-terminal protein lipidation
namespace: biological_process
def: "The covalent attachment of a lipid group to the carboxy terminus of a protein." [GOC:jl]
subset: gosubset_prok
xref: Reactome:REACT_102581 "Post-translational modification: synthesis of GPI-anchored proteins, Drosophila melanogaster"
xref: Reactome:REACT_105202 "Post-translational modification: synthesis of GPI-anchored proteins, Xenopus tropicalis"
xref: Reactome:REACT_106482 "Post-translational modification: synthesis of GPI-anchored proteins, Plasmodium falciparum"
xref: Reactome:REACT_106946 "Post-translational modification: synthesis of GPI-anchored proteins, Sus scrofa"
xref: Reactome:REACT_108145 "Post-translational modification: synthesis of GPI-anchored proteins, Canis familiaris"
xref: Reactome:REACT_109027 "Post-translational modification: synthesis of GPI-anchored proteins, Oryza sativa"
xref: Reactome:REACT_110699 "Post-translational modification: synthesis of GPI-anchored proteins, Mus musculus"
xref: Reactome:REACT_1853 "Post-translational modification: synthesis of GPI-anchored proteins, Homo sapiens"
xref: Reactome:REACT_81013 "Post-translational modification: synthesis of GPI-anchored proteins, Caenorhabditis elegans"
xref: Reactome:REACT_81111 "Post-translational modification: synthesis of GPI-anchored proteins, Taeniopygia guttata"
xref: Reactome:REACT_81593 "Post-translational modification: synthesis of GPI-anchored proteins, Arabidopsis thaliana"
xref: Reactome:REACT_81855 "Post-translational modification: synthesis of GPI-anchored proteins, Danio rerio"
xref: Reactome:REACT_86295 "Post-translational modification: synthesis of GPI-anchored proteins, Schizosaccharomyces pombe"
xref: Reactome:REACT_88504 "Post-translational modification: synthesis of GPI-anchored proteins, Dictyostelium discoideum"
xref: Reactome:REACT_89989 "Post-translational modification: synthesis of GPI-anchored proteins, Saccharomyces cerevisiae"
xref: Reactome:REACT_90235 "Post-translational modification: synthesis of GPI-anchored proteins, Rattus norvegicus"
xref: Reactome:REACT_93882 "Post-translational modification: synthesis of GPI-anchored proteins, Gallus gallus"
xref: Reactome:REACT_94699 "Post-translational modification: synthesis of GPI-anchored proteins, Bos taurus"
is_a: GO:0006497 ! protein lipidation
is_a: GO:0018410 ! C-terminal protein amino acid modification

[Term]
id: GO:0006502
name: obsolete C-terminal protein prenylation
namespace: biological_process
def: "OBSOLETE. The covalent or non-covalent attachment of a prenyl group to the carboxy terminus of a protein; geranyl, farnesyl, or geranylgeranyl groups may be added." [GOC:jl]
comment: This term was made obsolete because the process is not exclusive to the carboxy terminus of a protein.
synonym: "C-terminal protein prenylation" EXACT []
is_obsolete: true
replaced_by: GO:0018342

[Term]
id: GO:0006503
name: obsolete C-terminal protein farnesylation
namespace: biological_process
def: "OBSOLETE. The covalent or non-covalent attachment of a farnesyl group to the carboxy terminus of a protein." [GOC:jl]
comment: This term was made obsolete because the process is not exclusive to the carboxy terminus of a protein.
synonym: "C-terminal protein farnesylation" EXACT []
is_obsolete: true
replaced_by: GO:0018343

[Term]
id: GO:0006504
name: obsolete C-terminal protein geranylgeranylation
namespace: biological_process
def: "OBSOLETE. The covalent or non-covalent attachment of a geranylgeranyl group to the carboxy terminus of a protein." [GOC:jl]
comment: This term was made obsolete because the process is not exclusive to the carboxy terminus of a protein.
synonym: "C-terminal protein geranylgeranylation" EXACT []
is_obsolete: true
replaced_by: GO:0018344

[Term]
id: GO:0006505
name: GPI anchor metabolic process
namespace: biological_process
alt_id: GO:0046472
def: "The chemical reactions and pathways involving glycosylphosphatidylinositol anchors, molecular mechanisms for attaching membrane proteins to the lipid bilayer of cell membranes. Structurally they consist of a molecule of phosphatidylinositol to which is linked, via the C-6 hydroxyl of the inositol, a carbohydrate chain. This chain is in turn linked to the protein through an ethanolamine phosphate group, the amino group of which is in amide linkage with the C-terminal carboxyl of the protein chain, the phosphate group being esterified to the C-6 hydroxyl of the terminal mannose of the core carbohydrate chain." [ISBN:0198506732]
subset: gosubset_prok
synonym: "glycosylphosphatidylinositol metabolic process" EXACT []
synonym: "glycosylphosphatidylinositol metabolism" EXACT []
synonym: "GPI anchor metabolism" EXACT []
synonym: "GPI/GSI anchor metabolic process" BROAD []
synonym: "GPI/GSI anchor metabolism" BROAD []
is_a: GO:0006664 ! glycolipid metabolic process
is_a: GO:0046488 ! phosphatidylinositol metabolic process

[Term]
id: GO:0006506
name: GPI anchor biosynthetic process
namespace: biological_process
alt_id: GO:0015998
def: "The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]
subset: gosubset_prok
synonym: "glycosylphosphatidylinositol biosynthesis" EXACT []
synonym: "glycosylphosphatidylinositol biosynthetic process" EXACT []
synonym: "GPI anchor anabolism" EXACT []
synonym: "GPI anchor biosynthesis" EXACT []
synonym: "GPI anchor formation" EXACT []
synonym: "GPI anchor synthesis" EXACT []
synonym: "GPI/GSI anchor biosynthesis" BROAD []
synonym: "GPI/GSI anchor biosynthetic process" BROAD []
is_a: GO:0006497 ! protein lipidation
is_a: GO:0006505 ! GPI anchor metabolic process
is_a: GO:0006661 ! phosphatidylinositol biosynthetic process
is_a: GO:0009247 ! glycolipid biosynthetic process

[Term]
id: GO:0006507
name: GPI anchor release
namespace: biological_process
def: "The GPI anchor metabolic process that results in enzymatic cleavage of the anchor, releasing an anchored protein from the membrane." [GOC:mah, PMID:18811934]
subset: gosubset_prok
is_a: GO:0006505 ! GPI anchor metabolic process

[Term]
id: GO:0006508
name: proteolysis
namespace: biological_process
def: "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
comment: This term was intentionally placed under 'protein metabolic process ; GO:0019538' rather than 'protein catabolic process ; GO:0030163' to cover all processes centered on breaking peptide bonds, including those involved in protein processing.
subset: goslim_chembl
subset: goslim_pir
subset: gosubset_prok
synonym: "ATP-dependent proteolysis" NARROW [GOC:mah]
synonym: "peptidolysis" EXACT []
xref: Reactome:REACT_105459 "Removal of aminoterminal propeptides from gamma-carboxylated proteins, Gallus gallus"
xref: Reactome:REACT_106013 "Removal of aminoterminal propeptides from gamma-carboxylated proteins, Canis familiaris"
xref: Reactome:REACT_106377 "Removal of aminoterminal propeptides from gamma-carboxylated proteins, Mus musculus"
xref: Reactome:REACT_107219 "Removal of aminoterminal propeptides from gamma-carboxylated proteins, Danio rerio"
xref: Reactome:REACT_110326 "Removal of aminoterminal propeptides from gamma-carboxylated proteins, Bos taurus"
xref: Reactome:REACT_733 "Removal of aminoterminal propeptides from gamma-carboxylated proteins, Homo sapiens"
xref: Reactome:REACT_84556 "Removal of aminoterminal propeptides from gamma-carboxylated proteins, Xenopus tropicalis"
xref: Reactome:REACT_92566 "Removal of aminoterminal propeptides from gamma-carboxylated proteins, Sus scrofa"
xref: Reactome:REACT_95969 "Removal of aminoterminal propeptides from gamma-carboxylated proteins, Taeniopygia guttata"
xref: Reactome:REACT_98959 "Removal of aminoterminal propeptides from gamma-carboxylated proteins, Rattus norvegicus"
xref: Wikipedia:Proteolysis
is_a: GO:0019538 ! protein metabolic process

[Term]
id: GO:0006509
name: membrane protein ectodomain proteolysis
namespace: biological_process
def: "The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain)." [GOC:jl, http://www.copewithcytokines.de/]
subset: gosubset_prok
synonym: "ectoderm shedding" BROAD [GOC:pm, PMID:12096138, PMID:15672459, PMID:18419754]
synonym: "ectodomain cleavage" EXACT [PMID:18757500]
synonym: "membrane protein solubilization" RELATED []
synonym: "receptor shedding" RELATED []
is_a: GO:0033619 ! membrane protein proteolysis

[Term]
id: GO:0006510
name: obsolete ATP-dependent proteolysis
namespace: biological_process
def: "OBSOLETE. The hydrolysis of a peptide bond or bonds within a protein using energy from the hydrolysis of ATP." [GOC:jl]
comment: This term was made obsolete because it represents a molecular function.
synonym: "ATP-dependent peptidolysis" EXACT []
synonym: "ATP-dependent proteolysis" EXACT []
is_obsolete: true
replaced_by: GO:0004176
consider: GO:0006508
consider: GO:0016485
consider: GO:0051603

[Term]
id: GO:0006511
name: ubiquitin-dependent protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
synonym: "ubiquitin-dependent protein breakdown" EXACT []
synonym: "ubiquitin-dependent protein catabolism" EXACT []
synonym: "ubiquitin-dependent protein degradation" EXACT []
synonym: "ubiquitin-dependent proteolysis" EXACT []
is_a: GO:0019941 ! modification-dependent protein catabolic process

[Term]
id: GO:0006512
name: obsolete ubiquitin cycle
namespace: biological_process
def: "OBSOLETE. The cyclical process by which one or more ubiquitin groups are added to (ubiquitination) and removed from (deubiquitination) a protein." [PMID:11917093]
comment: This term was made obsolete because it implies that every protein that is ubiquitinated is also subsequently deubiquinitated, which is not true. Also, the process ontology does not include analogous terms for other small modifiers.
synonym: "ubiquitin cycle" EXACT []
is_obsolete: true

[Term]
id: GO:0006513
name: protein monoubiquitination
namespace: biological_process
def: "Addition of a single ubiquitin group to a protein." [GOC:ai]
synonym: "protein monoubiquitinylation" EXACT []
synonym: "protein monoubiquitylation" EXACT []
is_a: GO:0016567 ! protein ubiquitination

[Term]
id: GO:0006515
name: misfolded or incompletely synthesized protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins." [GOC:jl]
subset: gosubset_prok
synonym: "degradation of misfolded or incompletely synthesized proteins" EXACT []
synonym: "misfolded or incompletely synthesized protein breakdown" EXACT []
synonym: "misfolded or incompletely synthesized protein catabolism" EXACT []
synonym: "misfolded or incompletely synthesized protein degradation" EXACT []
is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process

[Term]
id: GO:0006516
name: glycoprotein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "glycoprotein breakdown" EXACT []
synonym: "glycoprotein catabolism" EXACT []
synonym: "glycoprotein degradation" EXACT []
is_a: GO:0009100 ! glycoprotein metabolic process
is_a: GO:0030163 ! protein catabolic process
is_a: GO:0044265 ! cellular macromolecule catabolic process
is_a: GO:1901136 ! carbohydrate derivative catabolic process

[Term]
id: GO:0006517
name: protein deglycosylation
namespace: biological_process
def: "The removal of sugar residues from a glycosylated protein." [GOC:mah]
subset: gosubset_prok
synonym: "glycoprotein deglycosylation" EXACT []
is_a: GO:0006464 ! cellular protein modification process

[Term]
id: GO:0006518
name: peptide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [CHEBI:16670, GOC:go_curators]
subset: goslim_pir
subset: gosubset_prok
synonym: "peptide metabolism" EXACT []
is_a: GO:0043603 ! cellular amide metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process

[Term]
id: GO:0006520
name: cellular amino acid metabolic process
namespace: biological_process
alt_id: GO:0006519
def: "The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells." [CHEBI:33709, GOC:curators, ISBN:0198506732]
subset: goslim_aspergillus
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "amino acid and derivative metabolism" EXACT [GOC:curators]
synonym: "amino acid metabolic process" EXACT [GOC:curators]
synonym: "cellular amino acid and derivative metabolic process" EXACT []
synonym: "cellular amino acid metabolism" EXACT []
xref: Reactome:REACT_116093 "Amino acid metabolism, Gallus gallus"
is_a: GO:0019752 ! carboxylic acid metabolic process
is_a: GO:0044238 ! primary metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process

[Term]
id: GO:0006521
name: regulation of cellular amino acid metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of amino acid metabolism" EXACT []
xref: Reactome:REACT_13565 "Regulation of ornithine decarboxylase (ODC), Homo sapiens"
xref: Reactome:REACT_28534 "Regulation of ornithine decarboxylase (ODC), Bos taurus"
xref: Reactome:REACT_33896 "Regulation of ornithine decarboxylase (ODC), Mus musculus"
xref: Reactome:REACT_81069 "Regulation of ornithine decarboxylase (ODC), Danio rerio"
xref: Reactome:REACT_81443 "Regulation of ornithine decarboxylase (ODC), Taeniopygia guttata"
xref: Reactome:REACT_85377 "Regulation of ornithine decarboxylase (ODC), Gallus gallus"
xref: Reactome:REACT_88753 "Regulation of ornithine decarboxylase (ODC), Rattus norvegicus"
xref: Reactome:REACT_95343 "Regulation of ornithine decarboxylase (ODC), Xenopus tropicalis"
xref: Reactome:REACT_95894 "Regulation of ornithine decarboxylase (ODC), Canis familiaris"
is_a: GO:0010565 ! regulation of cellular ketone metabolic process
is_a: GO:0033238 ! regulation of cellular amine metabolic process
is_a: GO:0080090 ! regulation of primary metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006520 ! cellular amino acid metabolic process
relationship: regulates GO:0006520 ! cellular amino acid metabolic process

[Term]
id: GO:0006522
name: alanine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving alanine, 2-aminopropanoic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "alanine metabolism" EXACT []
is_a: GO:0009078 ! pyruvate family amino acid metabolic process

[Term]
id: GO:0006523
name: alanine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of alanine, 2-aminopropanoic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "alanine anabolism" EXACT []
synonym: "alanine biosynthesis" EXACT []
synonym: "alanine formation" EXACT []
synonym: "alanine synthesis" EXACT []
is_a: GO:0006522 ! alanine metabolic process
is_a: GO:0009079 ! pyruvate family amino acid biosynthetic process

[Term]
id: GO:0006524
name: alanine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of alanine, 2-aminopropanoic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "alanine breakdown" EXACT []
synonym: "alanine catabolism" EXACT []
synonym: "alanine degradation" EXACT []
is_a: GO:0006522 ! alanine metabolic process
is_a: GO:0009080 ! pyruvate family amino acid catabolic process

[Term]
id: GO:0006525
name: arginine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [CHEBI:29016, GOC:go_curators]
subset: gosubset_prok
synonym: "arginine metabolism" EXACT []
xref: Reactome:REACT_115912 "Arginine metabolism, Gallus gallus"
xref: Wikipedia:Arginine
is_a: GO:0009064 ! glutamine family amino acid metabolic process

[Term]
id: GO:0006526
name: arginine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [CHEBI:29016, ISBN:0198506732]
subset: gosubset_prok
synonym: "arginine anabolism" EXACT []
synonym: "arginine biosynthesis" EXACT []
synonym: "arginine formation" EXACT []
synonym: "arginine synthesis" EXACT []
xref: MetaCyc:ARGININE-SYN4-PWY
xref: MetaCyc:ARGSYN-PWY
xref: MetaCyc:ARGSYNBSUB-PWY
is_a: GO:0006525 ! arginine metabolic process
is_a: GO:0009084 ! glutamine family amino acid biosynthetic process

[Term]
id: GO:0006527
name: arginine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [CHEBI:29016, GOC:go_curators]
subset: gosubset_prok
synonym: "arginine breakdown" EXACT []
synonym: "arginine catabolism" EXACT []
synonym: "arginine degradation" EXACT []
is_a: GO:0006525 ! arginine metabolic process
is_a: GO:0009065 ! glutamine family amino acid catabolic process

[Term]
id: GO:0006528
name: asparagine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving asparagine, 2-amino-3-carbamoylpropanoic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "asparagine metabolism" EXACT []
xref: MetaCyc:ASPARAGINESYN-PWY
is_a: GO:0009066 ! aspartate family amino acid metabolic process
is_a: GO:0043603 ! cellular amide metabolic process

[Term]
id: GO:0006529
name: asparagine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "asparagine anabolism" EXACT []
synonym: "asparagine biosynthesis" EXACT []
synonym: "asparagine formation" EXACT []
synonym: "asparagine synthesis" EXACT []
is_a: GO:0006528 ! asparagine metabolic process
is_a: GO:0009067 ! aspartate family amino acid biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process

[Term]
id: GO:0006530
name: asparagine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of asparagine, 2-amino-3-carbamoylpropanoic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "asparagine breakdown" EXACT []
synonym: "asparagine catabolism" EXACT []
synonym: "asparagine degradation" EXACT []
is_a: GO:0006528 ! asparagine metabolic process
is_a: GO:0009065 ! glutamine family amino acid catabolic process
is_a: GO:0009068 ! aspartate family amino acid catabolic process

[Term]
id: GO:0006531
name: aspartate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "aspartate metabolism" EXACT []
is_a: GO:0009066 ! aspartate family amino acid metabolic process
is_a: GO:0043648 ! dicarboxylic acid metabolic process

[Term]
id: GO:0006532
name: aspartate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "aspartate anabolism" EXACT []
synonym: "aspartate biosynthesis" EXACT []
synonym: "aspartate formation" EXACT []
synonym: "aspartate synthesis" EXACT []
is_a: GO:0006531 ! aspartate metabolic process
is_a: GO:0009067 ! aspartate family amino acid biosynthetic process
is_a: GO:0043650 ! dicarboxylic acid biosynthetic process

[Term]
id: GO:0006533
name: aspartate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "aspartate breakdown" EXACT []
synonym: "aspartate catabolism" EXACT []
synonym: "aspartate degradation" EXACT []
is_a: GO:0006531 ! aspartate metabolic process
is_a: GO:0009068 ! aspartate family amino acid catabolic process
is_a: GO:0043649 ! dicarboxylic acid catabolic process

[Term]
id: GO:0006534
name: cysteine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "cysteine metabolism" EXACT []
xref: Wikipedia:Cysteine_metabolism
is_a: GO:0000096 ! sulfur amino acid metabolic process
is_a: GO:0009069 ! serine family amino acid metabolic process

[Term]
id: GO:0006535
name: cysteine biosynthetic process from serine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine." [GOC:go_curators]
subset: gosubset_prok
synonym: "cysteine anabolism from serine" EXACT []
synonym: "cysteine formation from serine" EXACT []
synonym: "cysteine synthesis from serine" EXACT []
xref: MetaCyc:CYSTSYN-PWY
xref: Reactome:REACT_27198 "Cysteine synthesis from O-acetylserine, Mycobacterium tuberculosis"
xref: Reactome:REACT_27306 "Cysteine synthesis from O-phosphoserine, Mycobacterium tuberculosis"
is_a: GO:0006563 ! L-serine metabolic process
is_a: GO:0019344 ! cysteine biosynthetic process

[Term]
id: GO:0006536
name: glutamate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "glutamate metabolism" EXACT []
synonym: "glutamic acid metabolic process" EXACT []
synonym: "glutamic acid metabolism" EXACT []
xref: Wikipedia:Glutamic_acid
is_a: GO:0009064 ! glutamine family amino acid metabolic process
is_a: GO:0043648 ! dicarboxylic acid metabolic process

[Term]
id: GO:0006537
name: glutamate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "glutamate anabolism" EXACT []
synonym: "glutamate biosynthesis" EXACT []
synonym: "glutamate biosynthesis, using glutamate dehydrogenase (NAD(P)+)" NARROW []
synonym: "glutamate biosynthesis, using glutamate synthase (NADPH)" NARROW []
synonym: "glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+)" NARROW []
synonym: "glutamate biosynthetic process, using glutamate synthase (NADPH)" NARROW []
synonym: "glutamate formation" EXACT []
synonym: "glutamate synthesis" EXACT []
synonym: "glutamic acid biosynthesis" EXACT []
synonym: "glutamic acid biosynthetic process" EXACT []
is_a: GO:0006536 ! glutamate metabolic process
is_a: GO:0009084 ! glutamine family amino acid biosynthetic process
is_a: GO:0043650 ! dicarboxylic acid biosynthetic process

[Term]
id: GO:0006538
name: glutamate catabolic process
namespace: biological_process
alt_id: GO:0019459
def: "The chemical reactions and pathways resulting in the breakdown of glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "glutamate breakdown" EXACT []
synonym: "glutamate catabolism" EXACT []
synonym: "glutamate deamidation" RELATED []
synonym: "glutamate degradation" EXACT []
synonym: "glutamic acid catabolic process" EXACT []
synonym: "glutamic acid catabolism" EXACT []
is_a: GO:0006536 ! glutamate metabolic process
is_a: GO:0009065 ! glutamine family amino acid catabolic process
is_a: GO:0043649 ! dicarboxylic acid catabolic process

[Term]
id: GO:0006539
name: glutamate catabolic process via 2-oxoglutarate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate 2-oxoglutarate." [GOC:go_curators]
subset: gosubset_prok
synonym: "glutamate breakdown via 2-oxoglutarate" EXACT []
synonym: "glutamate catabolic process via 2-ketoglutarate" EXACT []
synonym: "glutamate catabolic process via alpha-ketoglutarate" EXACT []
synonym: "glutamate catabolic process via alpha-oxoglutarate" EXACT []
synonym: "glutamate catabolism via 2-ketoglutarate" EXACT []
synonym: "glutamate catabolism via alpha-ketoglutarate" EXACT []
synonym: "glutamate catabolism via alpha-oxoglutarate" EXACT []
synonym: "glutamate degradation via 2-oxoglutarate" EXACT []
xref: MetaCyc:P162-PWY
is_a: GO:0006103 ! 2-oxoglutarate metabolic process
is_a: GO:0006538 ! glutamate catabolic process

[Term]
id: GO:0006540
name: glutamate decarboxylation to succinate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of succinate from glutamate. Also known as GABA (gamma-aminobutyrate) shunt since it channels glutamate into the TCA cycle bypassing two steps of that cycle. There are three enzymes involved in the GABA shunt: glutamate decarboxylase (GAD), GABA aminotransferase (GABA-TA), and succinate semialdehyde dehydrogenase (SSADH). These three enzymes acting in concert to convert glutamate into succinate. The GABA shunt is predominantly associated with neurotransmission in the mammalian brain. It is also present in nonneuronal cells, in plants, in unicellular eukaryotes, and in prokaryotes." [PMID:12740438]
comment: Note that the third step in this pathway (conversion of succinate semialdehyde to succinate) can be catalyzed by NAD-dependent or NADP-dependent succinate semialdehyde dehydrogenase (EC:1.2.1.24 and EC:1.2.1.79, respectively).
subset: gosubset_prok
synonym: "4-aminobutyrate shunt" EXACT []
synonym: "degradation of glutamate to succinate through GABA" EXACT [MetaCyc:GLUDEG-I-PWY]
synonym: "GABA shunt" EXACT []
synonym: "gamma-aminobutyrate shunt" EXACT []
synonym: "glutamate degradation via 4-aminobutyrate" EXACT [MetaCyc:GLUDEG-I-PWY]
synonym: "glutamate degradation via GABA" EXACT [MetaCyc:GLUDEG-I-PWY]
xref: MetaCyc:GLUDEG-I-PWY
xref: MetaCyc:PWY-4321
xref: MetaCyc:PWY3O-210
is_a: GO:0006105 ! succinate metabolic process
is_a: GO:0006538 ! glutamate catabolic process
relationship: has_part GO:0003867 ! 4-aminobutyrate transaminase activity
relationship: has_part GO:0004351 ! glutamate decarboxylase activity

[Term]
id: GO:0006541
name: glutamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai]
subset: gosubset_prok
synonym: "glutamine metabolism" EXACT []
is_a: GO:0009064 ! glutamine family amino acid metabolic process

[Term]
id: GO:0006542
name: glutamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai]
subset: gosubset_prok
synonym: "glutamine anabolism" EXACT []
synonym: "glutamine biosynthesis" EXACT []
synonym: "glutamine formation" EXACT []
synonym: "glutamine synthesis" EXACT []
xref: MetaCyc:GLNSYN-PWY
is_a: GO:0006541 ! glutamine metabolic process
is_a: GO:0009084 ! glutamine family amino acid biosynthetic process

[Term]
id: GO:0006543
name: glutamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai]
subset: gosubset_prok
synonym: "glutamine breakdown" EXACT []
synonym: "glutamine catabolism" EXACT []
synonym: "glutamine degradation" EXACT []
is_a: GO:0006541 ! glutamine metabolic process
is_a: GO:0009065 ! glutamine family amino acid catabolic process

[Term]
id: GO:0006544
name: glycine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycine, aminoethanoic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "glycine metabolism" EXACT []
is_a: GO:0009069 ! serine family amino acid metabolic process

[Term]
id: GO:0006545
name: glycine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycine, aminoethanoic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "glycine anabolism" EXACT []
synonym: "glycine biosynthesis" EXACT []
synonym: "glycine formation" EXACT []
synonym: "glycine synthesis" EXACT []
xref: MetaCyc:GLYCINE-SYN2-PWY
is_a: GO:0006544 ! glycine metabolic process
is_a: GO:0009070 ! serine family amino acid biosynthetic process

[Term]
id: GO:0006546
name: glycine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "glycine breakdown" EXACT []
synonym: "glycine catabolism" EXACT []
synonym: "glycine degradation" EXACT []
is_a: GO:0006544 ! glycine metabolic process
is_a: GO:0009071 ! serine family amino acid catabolic process

[Term]
id: GO:0006547
name: histidine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "histidine metabolism" EXACT []
xref: Wikipedia:Histidine
is_a: GO:0052803 ! imidazole-containing compound metabolic process
is_a: GO:1901605 ! alpha-amino acid metabolic process

[Term]
id: GO:0006548
name: histidine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "histidine breakdown" EXACT []
synonym: "histidine catabolism" EXACT []
synonym: "histidine degradation" EXACT []
xref: Reactome:REACT_103215 "Histidine catabolism, Xenopus tropicalis"
xref: Reactome:REACT_103575 "Histidine catabolism, Sus scrofa"
xref: Reactome:REACT_104920 "Histidine catabolism, Danio rerio"
xref: Reactome:REACT_109147 "Histidine catabolism, Arabidopsis thaliana"
xref: Reactome:REACT_110335 "Histidine catabolism, Dictyostelium discoideum"
xref: Reactome:REACT_1249 "Histidine catabolism, Homo sapiens"
xref: Reactome:REACT_31534 "Histidine catabolism, Staphylococcus aureus N315"
xref: Reactome:REACT_34749 "Histidine catabolism, Mus musculus"
xref: Reactome:REACT_77814 "Histidine catabolism, Bos taurus"
xref: Reactome:REACT_82100 "Histidine catabolism, Caenorhabditis elegans"
xref: Reactome:REACT_95556 "Histidine catabolism, Taeniopygia guttata"
xref: Reactome:REACT_95594 "Histidine catabolism, Canis familiaris"
xref: Reactome:REACT_97313 "Histidine catabolism, Rattus norvegicus"
xref: Reactome:REACT_97852 "Histidine catabolism, Gallus gallus"
is_a: GO:0006547 ! histidine metabolic process
is_a: GO:0052805 ! imidazole-containing compound catabolic process
is_a: GO:1901606 ! alpha-amino acid catabolic process

[Term]
id: GO:0006549
name: isoleucine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid." [GOC:ai]
subset: gosubset_prok
synonym: "isoleucine metabolism" EXACT []
is_a: GO:0009081 ! branched-chain amino acid metabolic process
is_a: GO:1901605 ! alpha-amino acid metabolic process

[Term]
id: GO:0006550
name: isoleucine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid." [GOC:ai]
subset: gosubset_prok
synonym: "isoleucine breakdown" EXACT []
synonym: "isoleucine catabolism" EXACT []
synonym: "isoleucine degradation" EXACT []
xref: MetaCyc:ILEUDEG-PWY
is_a: GO:0006549 ! isoleucine metabolic process
is_a: GO:0009083 ! branched-chain amino acid catabolic process
is_a: GO:1901606 ! alpha-amino acid catabolic process

[Term]
id: GO:0006551
name: leucine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving leucine, 2-amino-4-methylpentanoic acid." [GOC:ai]
subset: gosubset_prok
synonym: "leucine metabolism" EXACT []
is_a: GO:0009081 ! branched-chain amino acid metabolic process
is_a: GO:1901605 ! alpha-amino acid metabolic process

[Term]
id: GO:0006552
name: leucine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of leucine, 2-amino-4-methylpentanoic acid." [GOC:ai]
subset: gosubset_prok
synonym: "leucine breakdown" EXACT []
synonym: "leucine catabolism" EXACT []
synonym: "leucine degradation" EXACT []
xref: MetaCyc:LEU-DEG2-PWY
is_a: GO:0006551 ! leucine metabolic process
is_a: GO:0009083 ! branched-chain amino acid catabolic process
is_a: GO:1901606 ! alpha-amino acid catabolic process

[Term]
id: GO:0006553
name: lysine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lysine, 2,6-diaminohexanoic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "lysine metabolism" EXACT []
xref: Wikipedia:Lysine
is_a: GO:0009066 ! aspartate family amino acid metabolic process

[Term]
id: GO:0006554
name: lysine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lysine, 2,6-diaminohexanoic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "lysine breakdown" EXACT []
synonym: "lysine catabolism" EXACT []
synonym: "lysine degradation" EXACT []
xref: Reactome:REACT_102798 "Lysine catabolism, Schizosaccharomyces pombe"
xref: Reactome:REACT_105666 "Lysine catabolism, Arabidopsis thaliana"
xref: Reactome:REACT_108346 "Lysine catabolism, Mycobacterium tuberculosis"
xref: Reactome:REACT_108391 "Lysine catabolism, Xenopus tropicalis"
xref: Reactome:REACT_109268 "Lysine catabolism, Bos taurus"
xref: Reactome:REACT_113274 "Lysine catabolism, Escherichia coli"
xref: Reactome:REACT_1298 "Lysine catabolism, Homo sapiens"
xref: Reactome:REACT_29074 "Lysine catabolism, Gallus gallus"
xref: Reactome:REACT_29109 "Lysine catabolism, Saccharomyces cerevisiae"
xref: Reactome:REACT_29468 "Lysine catabolism, Dictyostelium discoideum"
xref: Reactome:REACT_31804 "Lysine catabolism, Danio rerio"
xref: Reactome:REACT_78200 "Lysine catabolism, Staphylococcus aureus N315"
xref: Reactome:REACT_79163 "Lysine catabolism, Rattus norvegicus"
xref: Reactome:REACT_82423 "Lysine catabolism, Drosophila melanogaster"
xref: Reactome:REACT_82625 "Lysine catabolism, Oryza sativa"
xref: Reactome:REACT_85760 "Lysine catabolism, Taeniopygia guttata"
xref: Reactome:REACT_87206 "Lysine catabolism, Canis familiaris"
xref: Reactome:REACT_87717 "Lysine catabolism, Plasmodium falciparum"
xref: Reactome:REACT_88111 "Lysine catabolism, Sus scrofa"
xref: Reactome:REACT_90812 "Lysine catabolism, Mus musculus"
xref: Reactome:REACT_99862 "Lysine catabolism, Caenorhabditis elegans"
is_a: GO:0006553 ! lysine metabolic process
is_a: GO:0009068 ! aspartate family amino acid catabolic process

[Term]
id: GO:0006555
name: methionine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "methionine and threonine metabolic process" BROAD []
synonym: "methionine and threonine metabolism" BROAD []
synonym: "methionine metabolism" EXACT []
xref: UM-BBD_pathwayID:met
is_a: GO:0000096 ! sulfur amino acid metabolic process
is_a: GO:0009066 ! aspartate family amino acid metabolic process

[Term]
id: GO:0006556
name: S-adenosylmethionine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "S-adenosyl methionine biosynthesis" EXACT []
synonym: "S-adenosyl methionine biosynthetic process" EXACT []
synonym: "S-adenosylmethionine anabolism" EXACT []
synonym: "S-adenosylmethionine biosynthesis" EXACT []
synonym: "S-adenosylmethionine formation" EXACT []
synonym: "S-adenosylmethionine synthesis" EXACT []
synonym: "SAM biosynthetic process" EXACT []
xref: MetaCyc:SAM-PWY
is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0042398 ! cellular modified amino acid biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:0046129 ! purine ribonucleoside biosynthetic process
is_a: GO:0046500 ! S-adenosylmethionine metabolic process

[Term]
id: GO:0006557
name: S-adenosylmethioninamine biosynthetic process
namespace: biological_process
alt_id: GO:0006745
def: "The chemical reactions and pathways resulting in the formation of S-adenosylmethioninamine, (5-deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt." [GOC:mah, MetaCyc:S-ADENOSYLMETHIONINAMINE]
subset: gosubset_prok
synonym: "S-adenosylmethioninamine anabolism" EXACT []
synonym: "S-adenosylmethioninamine biosynthesis" EXACT []
synonym: "S-adenosylmethioninamine formation" EXACT []
synonym: "S-adenosylmethioninamine synthesis" EXACT []
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:0046129 ! purine ribonucleoside biosynthetic process
is_a: GO:0046499 ! S-adenosylmethioninamine metabolic process

[Term]
id: GO:0006558
name: L-phenylalanine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid." [CHEBI:17295, GOC:go_curators, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "L-phenylalanine metabolism" EXACT []
synonym: "phenylalanine metabolic process" BROAD []
synonym: "phenylalanine metabolism" BROAD []
is_a: GO:0009072 ! aromatic amino acid family metabolic process
is_a: GO:1902221 ! erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process

[Term]
id: GO:0006559
name: L-phenylalanine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "L-phenylalanine breakdown" EXACT []
synonym: "L-phenylalanine catabolism" EXACT []
synonym: "L-phenylalanine degradation" EXACT []
synonym: "phenylalanine catabolic process" BROAD []
synonym: "phenylalanine catabolism" BROAD []
xref: Reactome:REACT_100913 "Phenylalanine and tyrosine catabolism, Escherichia coli"
xref: Reactome:REACT_102605 "Phenylalanine and tyrosine catabolism, Mus musculus"
xref: Reactome:REACT_107205 "Phenylalanine and tyrosine catabolism, Taeniopygia guttata"
xref: Reactome:REACT_107451 "Phenylalanine and tyrosine catabolism, Drosophila melanogaster"
xref: Reactome:REACT_1786 "Phenylalanine and tyrosine catabolism, Homo sapiens"
xref: Reactome:REACT_29834 "Phenylalanine and tyrosine catabolism, Mycobacterium tuberculosis"
xref: Reactome:REACT_30732 "Phenylalanine and tyrosine catabolism, Dictyostelium discoideum"
xref: Reactome:REACT_34058 "Phenylalanine and tyrosine catabolism, Canis familiaris"
xref: Reactome:REACT_79098 "Phenylalanine and tyrosine catabolism, Rattus norvegicus"
xref: Reactome:REACT_83652 "Phenylalanine and tyrosine catabolism, Caenorhabditis elegans"
xref: Reactome:REACT_84000 "Phenylalanine and tyrosine catabolism, Bos taurus"
xref: Reactome:REACT_88002 "Phenylalanine and tyrosine catabolism, Staphylococcus aureus N315"
xref: Reactome:REACT_93872 "Phenylalanine and tyrosine catabolism, Danio rerio"
xref: Reactome:REACT_94181 "Phenylalanine and tyrosine catabolism, Gallus gallus"
xref: Reactome:REACT_98033 "Phenylalanine and tyrosine catabolism, Oryza sativa"
xref: Reactome:REACT_98201 "Phenylalanine and tyrosine catabolism, Arabidopsis thaliana"
xref: Reactome:REACT_98270 "Phenylalanine and tyrosine catabolism, Xenopus tropicalis"
xref: Reactome:REACT_98835 "Phenylalanine and tyrosine catabolism, Sus scrofa"
is_a: GO:0006558 ! L-phenylalanine metabolic process
is_a: GO:0009074 ! aromatic amino acid family catabolic process
is_a: GO:1902222 ! erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process

[Term]
id: GO:0006560
name: proline metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "proline metabolism" EXACT []
is_a: GO:0009064 ! glutamine family amino acid metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process

[Term]
id: GO:0006561
name: proline biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [ISBN:0198506732]
subset: gosubset_prok
synonym: "proline anabolism" EXACT []
synonym: "proline biosynthesis" EXACT []
synonym: "proline formation" EXACT []
synonym: "proline synthesis" EXACT []
xref: MetaCyc:PROSYN-PWY
xref: MetaCyc:PWY-3341
is_a: GO:0006560 ! proline metabolic process
is_a: GO:0009084 ! glutamine family amino acid biosynthetic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process

[Term]
id: GO:0006562
name: proline catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "proline breakdown" EXACT []
synonym: "proline catabolism" EXACT []
synonym: "proline degradation" EXACT []
xref: Reactome:REACT_1002 "Proline catabolism, Homo sapiens"
xref: Reactome:REACT_102504 "Proline catabolism, Saccharomyces cerevisiae"
xref: Reactome:REACT_103403 "Proline catabolism, Oryza sativa"
xref: Reactome:REACT_106325 "Proline catabolism, Arabidopsis thaliana"
xref: Reactome:REACT_109173 "Proline catabolism, Caenorhabditis elegans"
xref: Reactome:REACT_109207 "Proline catabolism, Drosophila melanogaster"
xref: Reactome:REACT_109474 "Proline catabolism, Bos taurus"
xref: Reactome:REACT_29511 "Proline catabolism, Staphylococcus aureus N315"
xref: Reactome:REACT_30022 "Proline catabolism, Xenopus tropicalis"
xref: Reactome:REACT_30853 "Proline catabolism, Mus musculus"
xref: Reactome:REACT_77859 "Proline catabolism, Escherichia coli"
xref: Reactome:REACT_81421 "Proline catabolism, Danio rerio"
xref: Reactome:REACT_83940 "Proline catabolism, Dictyostelium discoideum"
xref: Reactome:REACT_88837 "Proline catabolism, Mycobacterium tuberculosis"
xref: Reactome:REACT_91312 "Proline catabolism, Canis familiaris"
xref: Reactome:REACT_92368 "Proline catabolism, Schizosaccharomyces pombe"
xref: Reactome:REACT_93112 "Proline catabolism, Taeniopygia guttata"
xref: Reactome:REACT_95258 "Proline catabolism, Rattus norvegicus"
xref: Reactome:REACT_97264 "Proline catabolism, Gallus gallus"
is_a: GO:0006560 ! proline metabolic process
is_a: GO:0009065 ! glutamine family amino acid catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process

[Term]
id: GO:0006563
name: L-serine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [CHEBI:17115, GOC:ai, GOC:jsg]
subset: gosubset_prok
synonym: "L-serine metabolism" EXACT []
is_a: GO:0009069 ! serine family amino acid metabolic process

[Term]
id: GO:0006564
name: L-serine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [CHEBI:17115, GOC:ai, GOC:jsg]
subset: gosubset_prok
synonym: "L-serine anabolism" EXACT []
synonym: "L-serine biosynthesis" EXACT []
synonym: "L-serine formation" EXACT []
synonym: "L-serine synthesis" EXACT []
xref: MetaCyc:SERSYN-PWY
xref: Reactome:REACT_115789 "Serine biosynthesis, Homo sapiens"
is_a: GO:0006563 ! L-serine metabolic process
is_a: GO:0009070 ! serine family amino acid biosynthetic process

[Term]
id: GO:0006565
name: L-serine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [CHEBI:17115, GOC:ai, GOC:jsg]
subset: gosubset_prok
synonym: "L-serine breakdown" EXACT []
synonym: "L-serine catabolism" EXACT []
synonym: "L-serine degradation" EXACT []
xref: MetaCyc:SERDEG-PWY
is_a: GO:0006563 ! L-serine metabolic process
is_a: GO:0009071 ! serine family amino acid catabolic process

[Term]
id: GO:0006566
name: threonine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "methionine and threonine metabolic process" BROAD []
synonym: "methionine and threonine metabolism" BROAD []
synonym: "threonine metabolism" EXACT []
xref: UM-BBD_pathwayID:met
is_a: GO:0009066 ! aspartate family amino acid metabolic process

[Term]
id: GO:0006567
name: threonine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "threonine breakdown" EXACT []
synonym: "threonine catabolism" EXACT []
synonym: "threonine degradation" EXACT []
xref: MetaCyc:THREOCAT-PWY
xref: UM-BBD_pathwayID:met
is_a: GO:0006566 ! threonine metabolic process
is_a: GO:0009068 ! aspartate family amino acid catabolic process

[Term]
id: GO:0006568
name: tryptophan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid." [ISBN:0198547684]
subset: gosubset_prok
synonym: "tryptophan metabolism" EXACT []
xref: Wikipedia:Tryptophan
is_a: GO:0006586 ! indolalkylamine metabolic process
is_a: GO:0009072 ! aromatic amino acid family metabolic process
is_a: GO:1901605 ! alpha-amino acid metabolic process

[Term]
id: GO:0006569
name: tryptophan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid." [ISBN:0198547684]
subset: gosubset_prok
synonym: "tryptophan breakdown" EXACT []
synonym: "tryptophan catabolic process, using tryptophanase" NARROW []
synonym: "tryptophan catabolism" EXACT []
synonym: "tryptophan catabolism, using tryptophanase" NARROW []
synonym: "tryptophan degradation" EXACT []
xref: Reactome:REACT_107092 "Tryptophan catabolism, Danio rerio"
xref: Reactome:REACT_107343 "Tryptophan catabolism, Saccharomyces cerevisiae"
xref: Reactome:REACT_34744 "Tryptophan catabolism, Dictyostelium discoideum"
xref: Reactome:REACT_76959 "Tryptophan catabolism, Sus scrofa"
xref: Reactome:REACT_77360 "Tryptophan catabolism, Canis familiaris"
xref: Reactome:REACT_78080 "Tryptophan catabolism, Caenorhabditis elegans"
xref: Reactome:REACT_78991 "Tryptophan catabolism, Bos taurus"
xref: Reactome:REACT_80773 "Tryptophan catabolism, Gallus gallus"
xref: Reactome:REACT_81336 "Tryptophan catabolism, Drosophila melanogaster"
xref: Reactome:REACT_82610 "Tryptophan catabolism, Xenopus tropicalis"
xref: Reactome:REACT_83276 "Tryptophan catabolism, Taeniopygia guttata"
xref: Reactome:REACT_85774 "Tryptophan catabolism, Rattus norvegicus"
xref: Reactome:REACT_90199 "Tryptophan catabolism, Mus musculus"
xref: Reactome:REACT_916 "Tryptophan catabolism, Homo sapiens"
xref: Reactome:REACT_94354 "Tryptophan catabolism, Staphylococcus aureus N315"
is_a: GO:0006568 ! tryptophan metabolic process
is_a: GO:0009074 ! aromatic amino acid family catabolic process
is_a: GO:0046218 ! indolalkylamine catabolic process
is_a: GO:1901606 ! alpha-amino acid catabolic process

[Term]
id: GO:0006570
name: tyrosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "tyrosine metabolism" EXACT []
xref: UM-BBD_pathwayID:tyr
xref: Wikipedia:Tyrosine
is_a: GO:0009072 ! aromatic amino acid family metabolic process
is_a: GO:1901605 ! alpha-amino acid metabolic process

[Term]
id: GO:0006571
name: tyrosine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid." [GOC:sm]
subset: gosubset_prok
synonym: "tyrosine anabolism" EXACT []
synonym: "tyrosine biosynthesis" EXACT []
synonym: "tyrosine formation" EXACT []
synonym: "tyrosine synthesis" EXACT []
xref: MetaCyc:PWY-3461
is_a: GO:0006570 ! tyrosine metabolic process
is_a: GO:0009095 ! aromatic amino acid family biosynthetic process, prephenate pathway
is_a: GO:1901607 ! alpha-amino acid biosynthetic process

[Term]
id: GO:0006572
name: tyrosine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "tyrosine breakdown" EXACT []
synonym: "tyrosine catabolism" EXACT []
synonym: "tyrosine degradation" EXACT []
is_a: GO:0006570 ! tyrosine metabolic process
is_a: GO:0009074 ! aromatic amino acid family catabolic process
is_a: GO:1901606 ! alpha-amino acid catabolic process

[Term]
id: GO:0006573
name: valine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid." [GOC:ai]
subset: gosubset_prok
synonym: "valine metabolism" EXACT []
is_a: GO:0009081 ! branched-chain amino acid metabolic process
is_a: GO:1901605 ! alpha-amino acid metabolic process

[Term]
id: GO:0006574
name: valine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of valine, 2-amino-3-methylbutanoic acid." [GOC:ai]
subset: gosubset_prok
synonym: "valine breakdown" EXACT []
synonym: "valine catabolism" EXACT []
synonym: "valine degradation" EXACT []
xref: MetaCyc:VALDEG-PWY
is_a: GO:0006573 ! valine metabolic process
is_a: GO:0009083 ! branched-chain amino acid catabolic process
is_a: GO:1901606 ! alpha-amino acid catabolic process

[Term]
id: GO:0006575
name: cellular modified amino acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents." [CHEBI:83821, GOC:ai]
subset: gosubset_prok
synonym: "amino acid derivative metabolic process" EXACT [GOC:curators]
synonym: "cellular amino acid derivative metabolic process" EXACT [GOC:curators]
synonym: "cellular amino acid derivative metabolism" EXACT []
synonym: "cellular modified amino acid metabolism" EXACT [GOC:mah]
synonym: "modified amino acid metabolic process" EXACT [GOC:mah]
synonym: "modified amino acid metabolism" EXACT [GOC:mah]
is_a: GO:0044237 ! cellular metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process

[Term]
id: GO:0006576
name: cellular biogenic amine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters." [GOC:jl, ISBN:0395825172]
subset: gosubset_prok
synonym: "biogenic amine metabolism" EXACT []
is_a: GO:0044106 ! cellular amine metabolic process

[Term]
id: GO:0006577
name: amino-acid betaine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any betaine, the N-trimethyl derivative of an amino acid." [GOC:mah, ISBN:0198506732]
subset: gosubset_prok
synonym: "betaine metabolic process" EXACT []
synonym: "betaine metabolism" EXACT []
is_a: GO:0034641 ! cellular nitrogen compound metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process

[Term]
id: GO:0006578
name: amino-acid betaine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any betaine, the N-trimethyl derivative of an amino acid." [GOC:mah, ISBN:0198506732]
subset: gosubset_prok
synonym: "betaine anabolism" EXACT []
synonym: "betaine biosynthesis" EXACT []
synonym: "betaine biosynthetic process" EXACT []
synonym: "betaine formation" EXACT []
synonym: "betaine synthesis" EXACT []
is_a: GO:0006577 ! amino-acid betaine metabolic process
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process

[Term]
id: GO:0006579
name: amino-acid betaine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any betaine, the N-trimethyl derivative of an amino acid." [GOC:mah, ISBN:0198506732]
subset: gosubset_prok
synonym: "betaine breakdown" EXACT []
synonym: "betaine catabolic process" EXACT []
synonym: "betaine catabolism" EXACT []
synonym: "betaine degradation" EXACT []
is_a: GO:0006577 ! amino-acid betaine metabolic process
is_a: GO:0044270 ! cellular nitrogen compound catabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process

[Term]
id: GO:0006580
name: ethanolamine metabolic process
namespace: biological_process
alt_id: GO:0006645
def: "The chemical reactions and pathways involving ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine)." [CHEBI:16000, GOC:jl, ISBN:01928006X]
subset: gosubset_prok
synonym: "ethanolamine metabolism" EXACT []
is_a: GO:0034308 ! primary alcohol metabolic process
is_a: GO:0042439 ! ethanolamine-containing compound metabolic process
is_a: GO:0097164 ! ammonium ion metabolic process
is_a: GO:1901160 ! primary amino compound metabolic process

[Term]
id: GO:0006581
name: acetylcholine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of acetylcholine, the acetic acid ester of the organic base choline." [GOC:jl, ISBN:0192800752]
synonym: "acetylcholine breakdown" EXACT []
synonym: "acetylcholine catabolism" EXACT []
synonym: "acetylcholine degradation" EXACT []
is_a: GO:0008291 ! acetylcholine metabolic process
is_a: GO:0042135 ! neurotransmitter catabolic process
is_a: GO:0044712 ! single-organism catabolic process
is_a: GO:1901575 ! organic substance catabolic process

[Term]
id: GO:0006582
name: melanin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom." [GOC:go_curators]
subset: gosubset_prok
synonym: "melanin metabolism" EXACT []
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0042440 ! pigment metabolic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0006583
name: melanin biosynthetic process from tyrosine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of melanin from other compounds, including tyrosine." [GOC:go_curators]
subset: gosubset_prok
synonym: "melanin anabolism from tyrosine" EXACT []
synonym: "melanin formation from tyrosine" EXACT []
synonym: "melanin synthesis from tyrosine" EXACT []
is_a: GO:0006570 ! tyrosine metabolic process
is_a: GO:0042438 ! melanin biosynthetic process

[Term]
id: GO:0006584
name: catecholamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "catecholamine metabolism" EXACT []
is_a: GO:0009712 ! catechol-containing compound metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process

[Term]
id: GO:0006585
name: dopamine biosynthetic process from tyrosine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dopamine (3,4-dihydroxyphenylethylamine) from L-tyrosine, via the metabolic precursor 3,4-dihydroxy-L-phenylalanine (L-dopa). Dopamine is a catecholamine neurotransmitter and a metabolic precursor of norepinephrine and epinephrine." [GOC:bf, GOC:jl, ISBN:0198506732]
synonym: "dopamine anabolism from tyrosine" EXACT []
synonym: "dopamine formation from tyrosine" EXACT []
synonym: "dopamine synthesis from tyrosine" EXACT []
is_a: GO:0006570 ! tyrosine metabolic process
is_a: GO:0042416 ! dopamine biosynthetic process
is_a: GO:0044711 ! single-organism biosynthetic process

[Term]
id: GO:0006586
name: indolalkylamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group." [CHEBI:38631, GOC:curators]
subset: gosubset_prok
synonym: "indolalkylamine metabolism" EXACT []
synonym: "indolamine metabolic process" BROAD []
synonym: "indolamine metabolism" BROAD []
is_a: GO:0006576 ! cellular biogenic amine metabolic process
is_a: GO:0042430 ! indole-containing compound metabolic process

[Term]
id: GO:0006587
name: serotonin biosynthetic process from tryptophan
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation from tryptophan of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732]
synonym: "serotonin anabolism from tryptophan" EXACT []
synonym: "serotonin formation from tryptophan" EXACT []
synonym: "serotonin synthesis from tryptophan" EXACT []
is_a: GO:0006568 ! tryptophan metabolic process
is_a: GO:0042427 ! serotonin biosynthetic process
is_a: GO:0044711 ! single-organism biosynthetic process

[Term]
id: GO:0006588
name: activation of tryptophan 5-monooxygenase activity
namespace: biological_process
def: "The process in which the tryptophan 5-monooxygenase enzyme is changed so that it can carry out its enzymatic activity." [GOC:dph, GOC:tb]
synonym: "tryptophan hydroxylase activation" RELATED [GOC:dph, GOC:tb]
is_a: GO:0032770 ! positive regulation of monooxygenase activity
relationship: part_of GO:0006587 ! serotonin biosynthetic process from tryptophan

[Term]
id: GO:0006589
name: octopamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol. The D enantiomer is about one-tenth as active as norepinephrine and is found in the salivary glands of Octopus and Eledone species." [ISBN:0198506732]
synonym: "octopamine anabolism" EXACT []
synonym: "octopamine biosynthesis" EXACT []
synonym: "octopamine formation" EXACT []
synonym: "octopamine synthesis" EXACT []
is_a: GO:0042136 ! neurotransmitter biosynthetic process
is_a: GO:0042401 ! cellular biogenic amine biosynthetic process
is_a: GO:0046165 ! alcohol biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:0046333 ! octopamine metabolic process

[Term]
id: GO:0006590
name: thyroid hormone generation
namespace: biological_process
def: "The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones." [GOC:jl, ISBN:0716720094]
comment: Note that this term does not fall under the general GO definition for biosynthetic processes, which is 'The chemical reactions and pathways resulting in the formation of... ', because thyroid hormones can only be formed by the proteolysis of a larger molecule (see term definition). The word 'generation' is therefore used in place of biosynthesis.
xref: Reactome:REACT_100560 "Thyroxine biosynthesis, Sus scrofa"
xref: Reactome:REACT_101145 "Thyroxine biosynthesis, Bos taurus"
xref: Reactome:REACT_103574 "Thyroxine biosynthesis, Gallus gallus"
xref: Reactome:REACT_109249 "Thyroxine biosynthesis, Mus musculus"
xref: Reactome:REACT_15292 "Thyroxine biosynthesis, Homo sapiens"
xref: Reactome:REACT_28288 "Thyroxine biosynthesis, Dictyostelium discoideum"
xref: Reactome:REACT_28294 "Thyroxine biosynthesis, Drosophila melanogaster"
xref: Reactome:REACT_80508 "Thyroxine biosynthesis, Staphylococcus aureus N315"
xref: Reactome:REACT_80963 "Thyroxine biosynthesis, Canis familiaris"
xref: Reactome:REACT_90570 "Thyroxine biosynthesis, Taeniopygia guttata"
xref: Reactome:REACT_93623 "Thyroxine biosynthesis, Caenorhabditis elegans"
xref: Reactome:REACT_95788 "Thyroxine biosynthesis, Xenopus tropicalis"
xref: Reactome:REACT_97527 "Thyroxine biosynthesis, Rattus norvegicus"
xref: Reactome:REACT_99447 "Thyroxine biosynthesis, Danio rerio"
is_a: GO:0042403 ! thyroid hormone metabolic process

[Term]
id: GO:0006591
name: ornithine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis." [GOC:jl, ISBN:0192801023]
subset: gosubset_prok
synonym: "ornithine metabolism" EXACT []
is_a: GO:1901605 ! alpha-amino acid metabolic process

[Term]
id: GO:0006592
name: ornithine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis." [GOC:jl, ISBN:0192801023]
subset: gosubset_prok
synonym: "ornithine anabolism" EXACT []
synonym: "ornithine biosynthesis" EXACT []
synonym: "ornithine formation" EXACT []
synonym: "ornithine synthesis" EXACT []
is_a: GO:0006591 ! ornithine metabolic process
is_a: GO:1901607 ! alpha-amino acid biosynthetic process

[Term]
id: GO:0006593
name: ornithine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis." [GOC:jl, ISBN:0192801023]
subset: gosubset_prok
synonym: "ornithine breakdown" EXACT []
synonym: "ornithine catabolism" EXACT []
synonym: "ornithine degradation" EXACT []
is_a: GO:0006591 ! ornithine metabolic process
is_a: GO:1901606 ! alpha-amino acid catabolic process

[Term]
id: GO:0006595
name: polyamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving polyamines, any organic compound containing two or more amino groups." [ISBN:0198506732]
subset: gosubset_prok
synonym: "polyamine metabolism" EXACT []
xref: Reactome:REACT_100734 "Metabolism of polyamines, Arabidopsis thaliana"
xref: Reactome:REACT_103290 "Metabolism of polyamines, Sus scrofa"
xref: Reactome:REACT_108771 "Metabolism of polyamines, Staphylococcus aureus N315"
xref: Reactome:REACT_109739 "Metabolism of polyamines, Rattus norvegicus"
xref: Reactome:REACT_110328 "Metabolism of polyamines, Bos taurus"
xref: Reactome:REACT_110548 "Metabolism of polyamines, Plasmodium falciparum"
xref: Reactome:REACT_14820 "Metabolism of polyamines, Homo sapiens"
xref: Reactome:REACT_28762 "Metabolism of polyamines, Gallus gallus"
xref: Reactome:REACT_30589 "Metabolism of polyamines, Escherichia coli"
xref: Reactome:REACT_33056 "Metabolism of polyamines, Drosophila melanogaster"
xref: Reactome:REACT_80079 "Metabolism of polyamines, Mycobacterium tuberculosis"
xref: Reactome:REACT_80586 "Metabolism of polyamines, Saccharomyces cerevisiae"
xref: Reactome:REACT_83575 "Metabolism of polyamines, Canis familiaris"
xref: Reactome:REACT_85349 "Metabolism of polyamines, Xenopus tropicalis"
xref: Reactome:REACT_88143 "Metabolism of polyamines, Dictyostelium discoideum"
xref: Reactome:REACT_89998 "Metabolism of polyamines, Oryza sativa"
xref: Reactome:REACT_90774 "Metabolism of polyamines, Schizosaccharomyces pombe"
xref: Reactome:REACT_94316 "Metabolism of polyamines, Danio rerio"
xref: Reactome:REACT_95480 "Metabolism of polyamines, Mus musculus"
xref: Reactome:REACT_95585 "Metabolism of polyamines, Caenorhabditis elegans"
xref: Reactome:REACT_96719 "Metabolism of polyamines, Taeniopygia guttata"
is_a: GO:0006576 ! cellular biogenic amine metabolic process

[Term]
id: GO:0006596
name: polyamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups." [ISBN:0198506732]
subset: gosubset_prok
synonym: "polyamine anabolism" EXACT []
synonym: "polyamine biosynthesis" EXACT []
synonym: "polyamine formation" EXACT []
synonym: "polyamine synthesis" EXACT []
xref: MetaCyc:POLYAMSYN-PWY
xref: Reactome:REACT_101426 "Interconversion of polyamines, Gallus gallus"
xref: Reactome:REACT_103003 "Interconversion of polyamines, Mus musculus"
xref: Reactome:REACT_106961 "Interconversion of polyamines, Taeniopygia guttata"
xref: Reactome:REACT_108656 "Interconversion of polyamines, Bos taurus"
xref: Reactome:REACT_109579 "Interconversion of polyamines, Saccharomyces cerevisiae"
xref: Reactome:REACT_14805 "Interconversion of polyamines, Homo sapiens"
xref: Reactome:REACT_30796 "Interconversion of polyamines, Mycobacterium tuberculosis"
xref: Reactome:REACT_33133 "Interconversion of polyamines, Schizosaccharomyces pombe"
xref: Reactome:REACT_81055 "Interconversion of polyamines, Caenorhabditis elegans"
xref: Reactome:REACT_82262 "Interconversion of polyamines, Sus scrofa"
xref: Reactome:REACT_83590 "Interconversion of polyamines, Oryza sativa"
xref: Reactome:REACT_83997 "Interconversion of polyamines, Drosophila melanogaster"
xref: Reactome:REACT_86137 "Interconversion of polyamines, Arabidopsis thaliana"
xref: Reactome:REACT_88100 "Interconversion of polyamines, Xenopus tropicalis"
xref: Reactome:REACT_89483 "Interconversion of polyamines, Rattus norvegicus"
xref: Reactome:REACT_92493 "Interconversion of polyamines, Danio rerio"
xref: Reactome:REACT_95113 "Interconversion of polyamines, Dictyostelium discoideum"
xref: Reactome:REACT_95690 "Interconversion of polyamines, Canis familiaris"
is_a: GO:0006595 ! polyamine metabolic process
is_a: GO:0042401 ! cellular biogenic amine biosynthetic process

[Term]
id: GO:0006597
name: spermine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses and involved in nucleic acid packaging." [CHEBI:15746, GOC:curators]
subset: gosubset_prok
synonym: "spermine anabolism" EXACT []
synonym: "spermine biosynthesis" EXACT []
synonym: "spermine formation" EXACT []
synonym: "spermine synthesis" EXACT []
is_a: GO:0006596 ! polyamine biosynthetic process
is_a: GO:0008215 ! spermine metabolic process

[Term]
id: GO:0006598
name: polyamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of polyamines, any organic compound containing two or more amino groups." [ISBN:0198506732]
subset: gosubset_prok
synonym: "polyamine breakdown" EXACT []
synonym: "polyamine catabolism" EXACT []
synonym: "polyamine degradation" EXACT []
is_a: GO:0006595 ! polyamine metabolic process
is_a: GO:0042402 ! cellular biogenic amine catabolic process

[Term]
id: GO:0006599
name: phosphagen metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phosphagen, any of a group of guanidine phosphates that occur in muscle and can be used to regenerate ATP from ADP during muscular contraction." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "phosphagen metabolism" EXACT []
is_a: GO:0006575 ! cellular modified amino acid metabolic process
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process

[Term]
id: GO:0006600
name: creatine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving creatine (N-(aminoiminomethyl)-N-methylglycine), a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle." [GOC:jl, ISBN:0192801023]
subset: gosubset_prok
synonym: "creatine metabolism" EXACT []
xref: Reactome:REACT_106712 "Creatine metabolism, Mus musculus"
xref: Reactome:REACT_112303 "Creatine metabolism, Staphylococcus aureus N315"
xref: Reactome:REACT_32978 "Creatine metabolism, Bos taurus"
xref: Reactome:REACT_813 "Creatine metabolism, Homo sapiens"
xref: Reactome:REACT_82621 "Creatine metabolism, Rattus norvegicus"
xref: Reactome:REACT_84264 "Creatine metabolism, Taeniopygia guttata"
xref: Reactome:REACT_86004 "Creatine metabolism, Danio rerio"
xref: Reactome:REACT_87835 "Creatine metabolism, Sus scrofa"
xref: Reactome:REACT_90334 "Creatine metabolism, Xenopus tropicalis"
xref: Reactome:REACT_90480 "Creatine metabolism, Gallus gallus"
xref: Reactome:REACT_99832 "Creatine metabolism, Canis familiaris"
is_a: GO:0006575 ! cellular modified amino acid metabolic process
is_a: GO:1901605 ! alpha-amino acid metabolic process

[Term]
id: GO:0006601
name: creatine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of creatine, N-[amino(imino)methyl]-N-methylglycine. Creatine is formed by a process beginning with amidino group transfer from L-arginine to glycine to form guanidinoacetate, followed by methyl group transfer from S-adenosyl-L-methionine to guanidinoacetate; it is then is phosphorylated to form a pool that stores high energy phosphate for the replenishment of ATP during periods of high, or fluctuating energy demand. In animals, most creatine is transported to and used in muscle." [CHEBI:16919, GOC:mah, MetaCyc:GLYCGREAT-PWY, MetaCyc:PWY-6158]
subset: gosubset_prok
synonym: "creatine anabolism" EXACT []
synonym: "creatine biosynthesis" EXACT []
synonym: "creatine formation" EXACT []
synonym: "creatine synthesis" EXACT []
is_a: GO:0006600 ! creatine metabolic process
is_a: GO:0042398 ! cellular modified amino acid biosynthetic process
is_a: GO:1901607 ! alpha-amino acid biosynthetic process

[Term]
id: GO:0006602
name: creatinine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of creatinine, 2-amino-1,5-dihydro-1-methyl-4H-imidazol-4-one, an end product of creatine metabolism and a normal constituent of urine." [ISBN:0198506732]
subset: gosubset_prok
synonym: "creatinine breakdown" EXACT []
synonym: "creatinine catabolism" EXACT []
synonym: "creatinine degradation" EXACT []
is_a: GO:0046449 ! creatinine metabolic process
is_a: GO:0072340 ! cellular lactam catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process

[Term]
id: GO:0006603
name: phosphocreatine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phosphocreatine, a phosphagen of creatine present in high concentration in striated muscle which is synthesized and broken down by creatine phosphokinase to buffer ATP concentration. It acts as an immediate energy reserve for muscle." [CHEBI:17287, GOC:curators, PMID:16371597]
subset: gosubset_prok
synonym: "phosphocreatine metabolism" EXACT []
is_a: GO:0006599 ! phosphagen metabolic process

[Term]
id: GO:0006604
name: phosphoarginine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phosphoarginine, a phosphagen of L-arginine with phosphoric acid containing the phosphoamide bond. It is a source of energy in the contraction of muscle in invertebrates, corresponding to phosphocreatine in the muscles of vertebrates." [GOC:curators, PMID:16371597]
subset: gosubset_prok
synonym: "phosphoarginine metabolism" EXACT []
is_a: GO:0006599 ! phosphagen metabolic process
is_a: GO:1901605 ! alpha-amino acid metabolic process

[Term]
id: GO:0006605
name: protein targeting
namespace: biological_process
def: "The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif." [GOC:ma]
comment: Note that protein targeting encompasses the transport of the protein to the specified location, and may also include additional steps such as protein processing.
subset: goslim_chembl
subset: goslim_generic
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "nascent polypeptide association" RELATED []
synonym: "protein sorting along secretory pathway" NARROW []
xref: Wikipedia:Protein_targeting
is_a: GO:0006886 ! intracellular protein transport
is_a: GO:1902582 ! single-organism intracellular transport

[Term]
id: GO:0006606
name: protein import into nucleus
namespace: biological_process
def: "The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]
synonym: "establishment of protein localization to nucleus" EXACT [GOC:mah]
synonym: "protein import into cell nucleus" EXACT []
synonym: "protein nucleus import" EXACT []
synonym: "protein transport from cytoplasm to nucleus" EXACT []
is_a: GO:0006886 ! intracellular protein transport
is_a: GO:0017038 ! protein import
is_a: GO:0034504 ! protein localization to nucleus
is_a: GO:0072594 ! establishment of protein localization to organelle
is_a: GO:1902580 ! single-organism cellular localization
is_a: GO:1902593 ! single-organism nuclear import
relationship: part_of GO:0044744 ! protein targeting to nucleus

[Term]
id: GO:0006607
name: NLS-bearing protein import into nucleus
namespace: biological_process
def: "The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:ai]
synonym: "NLS-bearing substrate import into cell nucleus" EXACT []
synonym: "NLS-bearing substrate import into nucleus" EXACT [GOC:bf, GOC:jl]
synonym: "NLS-bearing substrate transport from cytoplasm to nucleus" EXACT []
synonym: "NLS-bearing substrate-nucleus import" EXACT []
is_a: GO:0006606 ! protein import into nucleus

[Term]
id: GO:0006608
name: snRNP protein import into nucleus
namespace: biological_process
def: "The directed movement of a small nuclear ribonucleoprotein from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:ai]
synonym: "snRNP protein import into cell nucleus" EXACT []
synonym: "snRNP protein transport from cytoplasm to nucleus" EXACT []
synonym: "snRNP protein-nucleus import" EXACT []
is_a: GO:0006606 ! protein import into nucleus
is_a: GO:0071167 ! ribonucleoprotein complex import into nucleus

[Term]
id: GO:0006609
name: mRNA-binding (hnRNP) protein import into nucleus
namespace: biological_process
def: "The directed movement of a heterogeneous nuclear ribonucleoprotein from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:mah]
synonym: "mRNA-binding (hnRNP) protein import into cell nucleus" EXACT []
synonym: "mRNA-binding (hnRNP) protein transport from cytoplasm to nucleus" EXACT []
synonym: "mRNA-binding (hnRNP) protein-nucleus import" EXACT []
is_a: GO:0006606 ! protein import into nucleus

[Term]
id: GO:0006610
name: ribosomal protein import into nucleus
namespace: biological_process
def: "The directed movement of a ribosomal protein from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:ai]
synonym: "ribosomal protein import into cell nucleus" EXACT []
synonym: "ribosomal protein transport from cytoplasm to nucleus" EXACT []
synonym: "ribosomal protein-nucleus import" EXACT []
is_a: GO:0006606 ! protein import into nucleus

[Term]
id: GO:0006611
name: protein export from nucleus
namespace: biological_process
alt_id: GO:0097349
def: "The directed movement of a protein from the nucleus into the cytoplasm." [GOC:jl]
synonym: "copper-induced protein export from nucleus" RELATED [GOC:al]
synonym: "protein export from cell nucleus" EXACT []
synonym: "protein export out of nucleus" EXACT []
synonym: "protein transport from nucleus to cytoplasm" EXACT []
synonym: "protein-nucleus export" EXACT []
is_a: GO:0006886 ! intracellular protein transport
is_a: GO:0051168 ! nuclear export
is_a: GO:1902582 ! single-organism intracellular transport

[Term]
id: GO:0006612
name: protein targeting to membrane
namespace: biological_process
def: "The process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:curators]
synonym: "protein membrane targeting" EXACT []
synonym: "protein-membrane targeting" EXACT []
is_a: GO:0006605 ! protein targeting
is_a: GO:0072657 ! protein localization to membrane
is_a: GO:0090150 ! establishment of protein localization to membrane

[Term]
id: GO:0006613
name: cotranslational protein targeting to membrane
namespace: biological_process
def: "The targeting of proteins to a membrane that occurs during translation. The transport of most secretory proteins, particularly those with more than 100 amino acids, into the endoplasmic reticulum lumen occurs in this manner, as does the import of some proteins into mitochondria." [ISBN:0716731363, PMID:10512867, PMID:16896215]
synonym: "cotranslational membrane targeting" EXACT []
synonym: "cotranslational protein membrane targeting" EXACT []
synonym: "cotranslational protein-membrane targeting" EXACT []
is_a: GO:0006612 ! protein targeting to membrane

[Term]
id: GO:0006614
name: SRP-dependent cotranslational protein targeting to membrane
namespace: biological_process
def: "The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane." [ISBN:0716731363]
synonym: "ER translocation" BROAD []
synonym: "SRP-dependent cotranslational membrane targeting" EXACT []
synonym: "SRP-dependent cotranslational protein-membrane targeting" EXACT []
xref: Reactome:REACT_115902 "SRP-dependent cotranslational protein targeting to membrane, Homo sapiens"
xref: Reactome:REACT_118153 "SRP-dependent cotranslational protein targeting to membrane, Drosophila melanogaster"
xref: Reactome:REACT_118173 "SRP-dependent cotranslational protein targeting to membrane, Bos taurus"
xref: Reactome:REACT_118175 "SRP-dependent cotranslational protein targeting to membrane, Plasmodium falciparum"
xref: Reactome:REACT_118177 "SRP-dependent cotranslational protein targeting to membrane, Oryza sativa"
xref: Reactome:REACT_118247 "SRP-dependent cotranslational protein targeting to membrane, Xenopus tropicalis"
xref: Reactome:REACT_118289 "SRP-dependent cotranslational protein targeting to membrane, Schizosaccharomyces pombe"
xref: Reactome:REACT_118393 "SRP-dependent cotranslational protein targeting to membrane, Mus musculus"
xref: Reactome:REACT_118417 "SRP-dependent cotranslational protein targeting to membrane, Taeniopygia guttata"
xref: Reactome:REACT_118424 "SRP-dependent cotranslational protein targeting to membrane, Canis familiaris"
xref: Reactome:REACT_118427 "SRP-dependent cotranslational protein targeting to membrane, Dictyostelium discoideum"
xref: Reactome:REACT_118436 "SRP-dependent cotranslational protein targeting to membrane, Caenorhabditis elegans"
xref: Reactome:REACT_118486 "SRP-dependent cotranslational protein targeting to membrane, Saccharomyces cerevisiae"
xref: Reactome:REACT_118502 "SRP-dependent cotranslational protein targeting to membrane, Arabidopsis thaliana"
xref: Reactome:REACT_118521 "SRP-dependent cotranslational protein targeting to membrane, Rattus norvegicus"
xref: Reactome:REACT_118548 "SRP-dependent cotranslational protein targeting to membrane, Danio rerio"
xref: Reactome:REACT_118553 "SRP-dependent cotranslational protein targeting to membrane, Gallus gallus"
is_a: GO:0006613 ! cotranslational protein targeting to membrane
is_a: GO:0045047 ! protein targeting to ER
relationship: has_part GO:0006412 ! translation

[Term]
id: GO:0006615
name: SRP-dependent cotranslational protein targeting to membrane, docking
namespace: biological_process
def: "The process in which an SRP-bound ribosome forms a complex with the SRP receptor in the ER membrane, allowing the ribosome to bind to the membrane, during cotranslational membrane targeting." [ISBN:0815316194]
synonym: "protein docking during SRP-dependent cotranslational protein targeting to membrane" EXACT []
synonym: "SRP-dependent cotranslational membrane targeting, docking" EXACT []
synonym: "SRP-dependent cotranslational protein-membrane targeting, docking" EXACT []
is_a: GO:0022615 ! protein to membrane docking
relationship: part_of GO:0006614 ! SRP-dependent cotranslational protein targeting to membrane

[Term]
id: GO:0006616
name: SRP-dependent cotranslational protein targeting to membrane, translocation
namespace: biological_process
def: "The process during cotranslational membrane targeting wherein proteins move across a membrane. SRP and its receptor initiate the transfer of the nascent chain across the endoplasmic reticulum (ER) membrane; they then dissociate from the chain, which is transferred to a set of transmembrane proteins, collectively called the translocon. Once the nascent chain translocon complex is assembled, the elongating chain passes directly from the large ribosomal subunit into the centers of the translocon, a protein-lined channel within the membrane. The growing chain is never exposed to the cytosol and does not fold until it reaches the ER lumen." [ISBN:0716731363]
synonym: "ER translocation" BROAD []
synonym: "SRP-dependent cotranslational membrane targeting, translocation" EXACT []
synonym: "SRP-dependent cotranslational protein-membrane targeting, translocation" EXACT []
synonym: "translocation during SRP-dependent cotranslational protein targeting to membrane" EXACT []
is_a: GO:0065002 ! intracellular protein transmembrane transport
relationship: part_of GO:0006614 ! SRP-dependent cotranslational protein targeting to membrane

[Term]
id: GO:0006617
name: SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition
namespace: biological_process
def: "The process in which SRP binds to the signal peptide in a nascent protein, causing protein elongation to pause, during cotranslational membrane targeting." [ISBN:0815316194]
synonym: "signal sequence recognition during SRP-dependent cotranslational protein targeting to membrane" EXACT []
synonym: "SRP-dependent cotranslational membrane targeting, signal sequence recognition" EXACT []
synonym: "SRP-dependent cotranslational protein-membrane targeting, signal sequence recognition" EXACT []
is_a: GO:0043623 ! cellular protein complex assembly
relationship: part_of GO:0006614 ! SRP-dependent cotranslational protein targeting to membrane

[Term]
id: GO:0006618
name: SRP-dependent cotranslational protein targeting to membrane, signal sequence processing
namespace: biological_process
def: "The removal of the signal peptide from a nascent protein during cotranslational membrane targeting." [ISBN:0815316194]
synonym: "signal sequence processing during SRP-dependent cotranslational protein targeting to membrane" EXACT []
synonym: "SRP-dependent cotranslational membrane targeting, signal sequence processing" EXACT []
synonym: "SRP-dependent cotranslational protein-membrane targeting, signal sequence processing" EXACT []
is_a: GO:0006465 ! signal peptide processing
relationship: part_of GO:0006614 ! SRP-dependent cotranslational protein targeting to membrane

[Term]
id: GO:0006619
name: obsolete SRP-independent cotranslational protein-membrane targeting
namespace: biological_process
def: "OBSOLETE. The targeting of proteins to a membrane that occurs during translation and is independent of SRP and signal recognition." [GOC:ai, PMID:11101515]
comment: This term was made obsolete because there is no evidence for the existence of this process.
synonym: "ER translocation" BROAD []
synonym: "SRP-independent cotranslational membrane targeting" EXACT []
synonym: "SRP-independent cotranslational protein-membrane targeting" EXACT []
is_obsolete: true

[Term]
id: GO:0006620
name: posttranslational protein targeting to membrane
namespace: biological_process
def: "The targeting of proteins to a membrane that occurs after their translation. Some secretory proteins exhibit posttranslational transport into the endoplasmic reticulum (ER) lumen: they are synthesized in their entirety on free cytosolic ribosomes and then released into the cytosol, where they are bound by chaperones which keep them in an unfolded state, and subsequently are translocated across the ER membrane." [ISBN:0716731363]
synonym: "posttranslational membrane targeting" EXACT []
synonym: "posttranslational protein membrane targeting" EXACT []
synonym: "posttranslational protein-membrane targeting" EXACT []
synonym: "SRP-independent protein-membrane targeting" EXACT []
is_a: GO:0006612 ! protein targeting to membrane
is_a: GO:0045047 ! protein targeting to ER

[Term]
id: GO:0006621
name: protein retention in ER lumen
namespace: biological_process
def: "The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. Sorting receptors retrieve proteins with ER localization signals, such as KDEL and HDEL sequences or some transmembrane domains, that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER." [ISBN:0716731363, PMID:12972550]
synonym: "maintenance of protein location in ER lumen" BROAD [GOC:dph, GOC:tb]
is_a: GO:0035437 ! maintenance of protein localization in endoplasmic reticulum

[Term]
id: GO:0006622
name: protein targeting to lysosome
namespace: biological_process
def: "The process of directing proteins towards the lysosome using signals contained within the protein." [GOC:curators]
synonym: "protein-lysosome targeting" EXACT []
is_a: GO:0006623 ! protein targeting to vacuole
is_a: GO:0007041 ! lysosomal transport
is_a: GO:0061462 ! protein localization to lysosome

[Term]
id: GO:0006623
name: protein targeting to vacuole
namespace: biological_process
def: "The process of directing proteins towards the vacuole, usually using signals contained within the protein." [GOC:curators]
synonym: "protein vacuolar targeting" EXACT []
synonym: "protein-vacuolar targeting" EXACT []
synonym: "protein-vacuole targeting" EXACT []
synonym: "vacuolar protein sorting" EXACT [GOC:vw]
is_a: GO:0006605 ! protein targeting
is_a: GO:0007034 ! vacuolar transport
is_a: GO:0072665 ! protein localization to vacuole
is_a: GO:0072666 ! establishment of protein localization to vacuole
is_a: GO:1902580 ! single-organism cellular localization

[Term]
id: GO:0006624
name: vacuolar protein processing
namespace: biological_process
def: "Protein processing that takes place in the vacuole. Most protein processing in the vacuole represents proteolytic cleavage of precursors to form active enzymes." [GOC:mah]
synonym: "vacuolar protein maturation" RELATED []
synonym: "vacuolar proteolysis" RELATED []
is_a: GO:0016485 ! protein processing
is_a: GO:0044267 ! cellular protein metabolic process
intersection_of: GO:0016485 ! protein processing
intersection_of: occurs_in GO:0005773 ! vacuole
relationship: occurs_in GO:0005773 ! vacuole

[Term]
id: GO:0006625
name: protein targeting to peroxisome
namespace: biological_process
def: "The process of directing proteins towards the peroxisome, usually using signals contained within the protein." [GOC:ai]
synonym: "protein-peroxisome targeting" EXACT []
is_a: GO:0006605 ! protein targeting
is_a: GO:0043574 ! peroxisomal transport
is_a: GO:0072662 ! protein localization to peroxisome
is_a: GO:0072663 ! establishment of protein localization to peroxisome

[Term]
id: GO:0006626
name: protein targeting to mitochondrion
namespace: biological_process
alt_id: GO:0043681
def: "The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein." [GOC:mcc, ISBN:0716731363]
synonym: "mitochondrial protein import" RELATED []
synonym: "mitochondrial translocation" RELATED []
synonym: "protein import into mitochondrion" EXACT []
synonym: "protein targeting to mitochondria" EXACT []
synonym: "protein-mitochondrial targeting" EXACT []
is_a: GO:0006605 ! protein targeting
is_a: GO:0006839 ! mitochondrial transport
is_a: GO:0070585 ! protein localization to mitochondrion
is_a: GO:0072655 ! establishment of protein localization to mitochondrion
is_a: GO:1902580 ! single-organism cellular localization
relationship: part_of GO:0007005 ! mitochondrion organization

[Term]
id: GO:0006627
name: protein processing involved in protein targeting to mitochondrion
namespace: biological_process
def: "The cleavage of peptide bonds in proteins, usually near the N terminus, contributing to the process of import into the mitochondrion. Several different peptidases mediate cleavage of proteins destined for different mitochondrial compartments." [GOC:mcc, PMID:12191769]
synonym: "mitochondrial processing" BROAD []
synonym: "mitochondrial protein processing during import" RELATED [GOC:dph, GOC:tb]
is_a: GO:0034982 ! mitochondrial protein processing
intersection_of: GO:0016485 ! protein processing
intersection_of: part_of GO:0006626 ! protein targeting to mitochondrion
relationship: part_of GO:0006626 ! protein targeting to mitochondrion

[Term]
id: GO:0006628
name: obsolete mitochondrial translocation
namespace: biological_process
def: "OBSOLETE. The translocation of proteins across the mitochondrial membrane. In the presence of a translocating chain, the outer membrane import machinery (MOM complex) and the inner membrane import machinery (MIM complex) form translocation contact sites as a part of the membrane preprotein import machinery." [PMID:7600576]
comment: This term was made obsolete because its definition was equivalent to that of the biological process term 'mitochondrial matrix protein import ; GO:0030150' while the mitochondrial translocation has a broader meaning; this led to mis-annotation.
synonym: "mitochondrial translocation" EXACT []
is_obsolete: true
consider: GO:0006626

[Term]
id: GO:0006629
name: lipid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "lipid metabolism" EXACT []
xref: Reactome:REACT_104930 "Lipid digestion, mobilization, and transport, Drosophila melanogaster"
xref: Reactome:REACT_107479 "Lipid digestion, mobilization, and transport, Xenopus tropicalis"
xref: Reactome:REACT_108775 "Lipid digestion, mobilization, and transport, Canis familiaris"
xref: Reactome:REACT_114669 "Lipid digestion, mobilization, and transport, Staphylococcus aureus N315"
xref: Reactome:REACT_115652 "Lipid metabolism, Gallus gallus"
xref: Reactome:REACT_28745 "Lipid digestion, mobilization, and transport, Saccharomyces cerevisiae"
xref: Reactome:REACT_31395 "Lipid digestion, mobilization, and transport, Sus scrofa"
xref: Reactome:REACT_32539 "Lipid digestion, mobilization, and transport, Bos taurus"
xref: Reactome:REACT_33836 "Lipid digestion, mobilization, and transport, Rattus norvegicus"
xref: Reactome:REACT_602 "Lipid digestion, mobilization, and transport, Homo sapiens"
xref: Reactome:REACT_77176 "Lipid digestion, mobilization, and transport, Danio rerio"
xref: Reactome:REACT_77191 "Lipid digestion, mobilization, and transport, Arabidopsis thaliana"
xref: Reactome:REACT_79244 "Lipid digestion, mobilization, and transport, Plasmodium falciparum"
xref: Reactome:REACT_81778 "Lipid digestion, mobilization, and transport, Oryza sativa"
xref: Reactome:REACT_82512 "Lipid digestion, mobilization, and transport, Taeniopygia guttata"
xref: Reactome:REACT_82723 "Lipid digestion, mobilization, and transport, Escherichia coli"
xref: Reactome:REACT_87884 "Lipid digestion, mobilization, and transport, Caenorhabditis elegans"
xref: Reactome:REACT_90757 "Lipid digestion, mobilization, and transport, Mus musculus"
xref: Reactome:REACT_94607 "Lipid digestion, mobilization, and transport, Mycobacterium tuberculosis"
xref: Reactome:REACT_97906 "Lipid digestion, mobilization, and transport, Gallus gallus"
xref: Reactome:REACT_98129 "Lipid digestion, mobilization, and transport, Schizosaccharomyces pombe"
xref: Reactome:REACT_99706 "Lipid digestion, mobilization, and transport, Dictyostelium discoideum"
xref: Wikipedia:Lipid_metabolism
is_a: GO:0044238 ! primary metabolic process
is_a: GO:0044710 ! single-organism metabolic process
is_a: GO:0071704 ! organic substance metabolic process

[Term]
id: GO:0006630
name: obsolete lipid binding
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a molecular function and not a biological process.
synonym: "lipid binding" EXACT []
is_obsolete: true
consider: GO:0008289

[Term]
id: GO:0006631
name: fatty acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198547684]
subset: gosubset_prok
synonym: "fatty acid metabolism" EXACT []
xref: Reactome:REACT_32309 "CYP4A11 omega-hydroxylates laurate, Danio rerio"
xref: Reactome:REACT_58734 "CYP4A11 omega-hydroxylates laurate, Bos taurus"
xref: Reactome:REACT_82917 "CYP4A11 omega-hydroxylates laurate, Sus scrofa"
xref: Reactome:REACT_84240 "CYP4A11 omega-hydroxylates laurate, Mus musculus"
xref: Reactome:REACT_89918 "CYP4A11 omega-hydroxylates laurate, Xenopus tropicalis"
xref: Reactome:REACT_92163 "CYP4A11 omega-hydroxylates laurate, Gallus gallus"
xref: Reactome:REACT_98 "CYP4A11 omega-hydroxylates laurate, Homo sapiens"
xref: Reactome:REACT_99726 "CYP4A11 omega-hydroxylates laurate, Canis familiaris"
xref: Wikipedia:Fatty_acid_metabolism
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0044255 ! cellular lipid metabolic process

[Term]
id: GO:0006633
name: fatty acid biosynthetic process
namespace: biological_process
alt_id: GO:0000037
def: "The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]
subset: gosubset_prok
synonym: "fatty acid anabolism" EXACT []
synonym: "fatty acid biosynthesis" EXACT []
synonym: "fatty acid formation" EXACT []
synonym: "fatty acid synthesis" EXACT []
xref: MetaCyc:FASYN-INITIAL-PWY
xref: MetaCyc:PWY-4381
xref: MetaCyc:PWY-5156
xref: Wikipedia:Fatty_acid_synthesis
is_a: GO:0006631 ! fatty acid metabolic process
is_a: GO:0008610 ! lipid biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process

[Term]
id: GO:0006634
name: hexadecanal biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of hexadecanal, the C16 straight chain aldehyde." [http://chemfinder.cambridgesoft.com/]
subset: gosubset_prok
synonym: "hexadecanal anabolism" EXACT []
synonym: "hexadecanal biosynthesis" EXACT []
synonym: "hexadecanal formation" EXACT []
synonym: "hexadecanal synthesis" EXACT []
synonym: "palmitaldehyde biosynthesis" EXACT []
synonym: "palmitaldehyde biosynthetic process" EXACT []
is_a: GO:0046184 ! aldehyde biosynthetic process
is_a: GO:0046458 ! hexadecanal metabolic process

[Term]
id: GO:0006635
name: fatty acid beta-oxidation
namespace: biological_process
def: "A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]
subset: gosubset_prok
xref: Reactome:REACT_100596 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids, Caenorhabditis elegans"
xref: Reactome:REACT_101364 "Mitochondrial Fatty Acid Beta-Oxidation, Taeniopygia guttata"
xref: Reactome:REACT_101504 "Mitochondrial Fatty Acid Beta-Oxidation, Bos taurus"
xref: Reactome:REACT_101516 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA, Taeniopygia guttata"
xref: Reactome:REACT_101544 "Mitochondrial Fatty Acid Beta-Oxidation, Danio rerio"
xref: Reactome:REACT_101552 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids, Rattus norvegicus"
xref: Reactome:REACT_101715 "Mitochondrial Fatty Acid Beta-Oxidation, Gallus gallus"
xref: Reactome:REACT_101760 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA, Sus scrofa"
xref: Reactome:REACT_102384 "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA, Rattus norvegicus"
xref: Reactome:REACT_102647 "Mitochondrial Fatty Acid Beta-Oxidation, Arabidopsis thaliana"
xref: Reactome:REACT_105300 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Sus scrofa"
xref: Reactome:REACT_106047 "Mitochondrial Fatty Acid Beta-Oxidation, Dictyostelium discoideum"
xref: Reactome:REACT_106546 "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA, Taeniopygia guttata"
xref: Reactome:REACT_107615 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Danio rerio"
xref: Reactome:REACT_108125 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA, Sus scrofa"
xref: Reactome:REACT_109400 "Mitochondrial Fatty Acid Beta-Oxidation, Xenopus tropicalis"
xref: Reactome:REACT_109946 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids, Danio rerio"
xref: Reactome:REACT_109966 "Mitochondrial Fatty Acid Beta-Oxidation, Mycobacterium tuberculosis"
xref: Reactome:REACT_109985 "Mitochondrial Fatty Acid Beta-Oxidation, Rattus norvegicus"
xref: Reactome:REACT_110323 "Mitochondrial Fatty Acid Beta-Oxidation, Canis familiaris"
xref: Reactome:REACT_1111 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA, Homo sapiens"
xref: Reactome:REACT_113891 "Mitochondrial Fatty Acid Beta-Oxidation, Staphylococcus aureus N315"
xref: Reactome:REACT_1445 "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA, Homo sapiens"
xref: Reactome:REACT_1473 "Mitochondrial Fatty Acid Beta-Oxidation, Homo sapiens"
xref: Reactome:REACT_160 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids, Homo sapiens"
xref: Reactome:REACT_164 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA, Homo sapiens"
xref: Reactome:REACT_2238 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Homo sapiens"
xref: Reactome:REACT_28196 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA, Drosophila melanogaster"
xref: Reactome:REACT_28704 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids, Bos taurus"
xref: Reactome:REACT_31237 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA, Xenopus tropicalis"
xref: Reactome:REACT_31586 "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA, Gallus gallus"
xref: Reactome:REACT_31820 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Rattus norvegicus"
xref: Reactome:REACT_32648 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA, Mus musculus"
xref: Reactome:REACT_32695 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Danio rerio"
xref: Reactome:REACT_33031 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Sus scrofa"
xref: Reactome:REACT_33795 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Taeniopygia guttata"
xref: Reactome:REACT_34789 "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA, Bos taurus"
xref: Reactome:REACT_440 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Homo sapiens"
xref: Reactome:REACT_76925 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids, Sus scrofa"
xref: Reactome:REACT_76993 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids, Canis familiaris"
xref: Reactome:REACT_77947 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA, Canis familiaris"
xref: Reactome:REACT_79059 "Mitochondrial Fatty Acid Beta-Oxidation, Drosophila melanogaster"
xref: Reactome:REACT_79660 "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA, Canis familiaris"
xref: Reactome:REACT_79787 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA, Rattus norvegicus"
xref: Reactome:REACT_80377 "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA, Mycobacterium tuberculosis"
xref: Reactome:REACT_80706 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Rattus norvegicus"
xref: Reactome:REACT_81140 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids, Taeniopygia guttata"
xref: Reactome:REACT_81411 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA, Xenopus tropicalis"
xref: Reactome:REACT_81483 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Mus musculus"
xref: Reactome:REACT_81660 "Mitochondrial Fatty Acid Beta-Oxidation, Sus scrofa"
xref: Reactome:REACT_81792 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids, Mus musculus"
xref: Reactome:REACT_84440 "Mitochondrial Fatty Acid Beta-Oxidation, Mus musculus"
xref: Reactome:REACT_85225 "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA, Mus musculus"
xref: Reactome:REACT_86074 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Taeniopygia guttata"
xref: Reactome:REACT_86077 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Gallus gallus"
xref: Reactome:REACT_86330 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Mus musculus"
xref: Reactome:REACT_87006 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Bos taurus"
xref: Reactome:REACT_87412 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA, Danio rerio"
xref: Reactome:REACT_87857 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA, Bos taurus"
xref: Reactome:REACT_87883 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA, Gallus gallus"
xref: Reactome:REACT_88762 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Mycobacterium tuberculosis"
xref: Reactome:REACT_89119 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA, Mycobacterium tuberculosis"
xref: Reactome:REACT_89472 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA, Taeniopygia guttata"
xref: Reactome:REACT_89599 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA, Caenorhabditis elegans"
xref: Reactome:REACT_89974 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA, Bos taurus"
xref: Reactome:REACT_91623 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids, Mycobacterium tuberculosis"
xref: Reactome:REACT_91641 "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA, Danio rerio"
xref: Reactome:REACT_91800 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA, Mus musculus"
xref: Reactome:REACT_92535 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Xenopus tropicalis"
xref: Reactome:REACT_93029 "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA, Drosophila melanogaster"
xref: Reactome:REACT_94076 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Mycobacterium tuberculosis"
xref: Reactome:REACT_94209 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA, Canis familiaris"
xref: Reactome:REACT_94345 "Mitochondrial Fatty Acid Beta-Oxidation, Caenorhabditis elegans"
xref: Reactome:REACT_94432 "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA, Xenopus tropicalis"
xref: Reactome:REACT_94548 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Gallus gallus"
xref: Reactome:REACT_95023 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA, Danio rerio"
xref: Reactome:REACT_95378 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Xenopus tropicalis"
xref: Reactome:REACT_96770 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA, Rattus norvegicus"
xref: Reactome:REACT_97033 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids, Xenopus tropicalis"
xref: Reactome:REACT_97183 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids, Gallus gallus"
xref: Reactome:REACT_97665 "Mitochondrial Fatty Acid Beta-Oxidation, Escherichia coli"
xref: Reactome:REACT_98593 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids, Drosophila melanogaster"
xref: Reactome:REACT_99104 "Mitochondrial Fatty Acid Beta-Oxidation, Oryza sativa"
xref: Reactome:REACT_99180 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA, Caenorhabditis elegans"
xref: Reactome:REACT_99776 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Bos taurus"
is_a: GO:0009062 ! fatty acid catabolic process
is_a: GO:0019395 ! fatty acid oxidation

[Term]
id: GO:0006636
name: unsaturated fatty acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms." [GOC:mah, MetaCyc:PWY-762, MetaCyc:PWY-782]
subset: gosubset_prok
synonym: "fatty acid desaturation" RELATED []
synonym: "polyunsaturated fatty acid biosynthesis" NARROW [GOC:yaf, MetaCyc:PWY-762]
synonym: "unsaturated fatty acid anabolism" EXACT []
synonym: "unsaturated fatty acid biosynthesis" EXACT []
synonym: "unsaturated fatty acid formation" EXACT []
synonym: "unsaturated fatty acid synthesis" EXACT []
xref: MetaCyc:PWY-762
xref: MetaCyc:PWY-782
is_a: GO:0006633 ! fatty acid biosynthetic process
is_a: GO:0033559 ! unsaturated fatty acid metabolic process

[Term]
id: GO:0006637
name: acyl-CoA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group." [ISBN:0198506732]
subset: gosubset_prok
synonym: "acyl-CoA metabolism" EXACT []
is_a: GO:0006732 ! coenzyme metabolic process
is_a: GO:0006793 ! phosphorus metabolic process
is_a: GO:0035383 ! thioester metabolic process

[Term]
id: GO:0006638
name: neutral lipid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving neutral lipids, lipids only soluble in solvents of very low polarity." [ISBN:0198547684]
subset: gosubset_prok
synonym: "neutral lipid metabolism" EXACT []
is_a: GO:0044255 ! cellular lipid metabolic process

[Term]
id: GO:0006639
name: acylglycerol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids." [ISBN:0198506732]
subset: gosubset_prok
synonym: "acylglycerol metabolism" EXACT []
synonym: "glyceride metabolic process" EXACT []
synonym: "glyceride metabolism" EXACT []
is_a: GO:0006638 ! neutral lipid metabolic process
is_a: GO:0046486 ! glycerolipid metabolic process

[Term]
id: GO:0006640
name: monoacylglycerol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified." [ISBN:0198506732]
subset: gosubset_prok
synonym: "monoacylglycerol anabolism" EXACT []
synonym: "monoacylglycerol biosynthesis" EXACT []
synonym: "monoacylglycerol formation" EXACT []
synonym: "monoacylglycerol synthesis" EXACT []
synonym: "monoglyceride biosynthesis" EXACT []
synonym: "monoglyceride biosynthetic process" EXACT []
is_a: GO:0046462 ! monoacylglycerol metabolic process
is_a: GO:0046463 ! acylglycerol biosynthetic process

[Term]
id: GO:0006641
name: triglyceride metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins." [ISBN:0198506732]
subset: gosubset_prok
synonym: "triacylglycerol metabolic process" EXACT []
synonym: "triacylglycerol metabolism" EXACT []
synonym: "triglyceride metabolism" EXACT []
is_a: GO:0006639 ! acylglycerol metabolic process

[Term]
id: GO:0006642
name: triglyceride mobilization
namespace: biological_process
def: "The release of triglycerides, any triester of glycerol, from storage within cells or tissues, making them available for metabolism." [GOC:mah, PMID:11943743, PMID:15713625]
subset: gosubset_prok
synonym: "triacylglycerol mobilization" EXACT []
is_a: GO:0006641 ! triglyceride metabolic process

[Term]
id: GO:0006643
name: membrane lipid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving membrane lipids, any lipid found in or associated with a biological membrane." [GOC:ai]
subset: gosubset_prok
synonym: "membrane lipid metabolism" EXACT []
is_a: GO:0044255 ! cellular lipid metabolic process

[Term]
id: GO:0006644
name: phospholipid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]
subset: gosubset_prok
synonym: "phospholipid metabolism" EXACT []
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:0044255 ! cellular lipid metabolic process

[Term]
id: GO:0006646
name: phosphatidylethanolamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine." [ISBN:0198506732]
subset: gosubset_prok
synonym: "phosphatidylethanolamine anabolism" EXACT []
synonym: "phosphatidylethanolamine biosynthesis" EXACT []
synonym: "phosphatidylethanolamine formation" EXACT []
synonym: "phosphatidylethanolamine synthesis" EXACT []
is_a: GO:0046337 ! phosphatidylethanolamine metabolic process
is_a: GO:0046474 ! glycerophospholipid biosynthetic process

[Term]
id: GO:0006647
name: phosphatidyl-N-monomethylethanolamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways involving phosphatidyl-N-monomethylethanolamine (PMME), a derivative of phosphatidylethanolamine with a methylated amine group." [GOC:ai]
subset: gosubset_prok
synonym: "phosphatidyl-N-monomethylethanolamine anabolism" EXACT []
synonym: "phosphatidyl-N-monomethylethanolamine biosynthesis" EXACT []
synonym: "phosphatidyl-N-monomethylethanolamine formation" EXACT []
synonym: "phosphatidyl-N-monomethylethanolamine synthesis" EXACT []
synonym: "PMME biosynthesis" EXACT []
synonym: "PMME biosynthetic process" EXACT []
is_a: GO:0006646 ! phosphatidylethanolamine biosynthetic process
is_a: GO:0046468 ! phosphatidyl-N-monomethylethanolamine metabolic process

[Term]
id: GO:0006648
name: dihydrosphingosine-1-P pathway
namespace: biological_process
def: "A phosphatidylethanolamine biosynthetic process that proceeds via the enzymatic action of dihydrosphingosine phosphate lyase." [GOC:mah, PMID:15643073]
subset: gosubset_prok
is_a: GO:0006646 ! phosphatidylethanolamine biosynthetic process

[Term]
id: GO:0006649
name: phospholipid transfer to membrane
namespace: biological_process
def: "The transfer of a phospholipid from its site of synthesis to the plasma membrane." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0015914 ! phospholipid transport
relationship: part_of GO:0044802 ! single-organism membrane organization

[Term]
id: GO:0006650
name: glycerophospholipid metabolic process
namespace: biological_process
alt_id: GO:0006652
def: "The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732]
subset: gosubset_prok
synonym: "alpha-glycerophosphate pathway" RELATED []
synonym: "glycerophospholipid metabolism" EXACT []
synonym: "phosphoglyceride metabolic process" EXACT []
synonym: "phosphoglyceride metabolism" EXACT []
is_a: GO:0006644 ! phospholipid metabolic process
is_a: GO:0046486 ! glycerolipid metabolic process

[Term]
id: GO:0006651
name: diacylglycerol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group." [CHEBI:18035, GOC:curators]
subset: gosubset_prok
synonym: "diacylglycerol anabolism" EXACT []
synonym: "diacylglycerol biosynthesis" EXACT []
synonym: "diacylglycerol formation" EXACT []
synonym: "diacylglycerol synthesis" EXACT []
synonym: "diglyceride biosynthesis" EXACT []
is_a: GO:0046339 ! diacylglycerol metabolic process
is_a: GO:0046463 ! acylglycerol biosynthetic process

[Term]
id: GO:0006653
name: 1,2-diacyl-sn-glycero-3-phosphocholine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any 1,2-diacyl-sn-glycero-3-phosphocholine, the compounds most commonly designated lecithin." [CHEBI:16110, ISBN:0198506732]
subset: gosubset_prok
synonym: "1,2-diacyl-sn-glycero-3-phosphocholine metabolism" EXACT [GOC:mah]
synonym: "lecithin metabolic process" BROAD [CHEBI:16110]
is_a: GO:0046470 ! phosphatidylcholine metabolic process

[Term]
id: GO:0006654
name: phosphatidic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids." [ISBN:0198506732]
subset: gosubset_prok
synonym: "phosphatidic acid anabolism" EXACT []
synonym: "phosphatidic acid biosynthesis" EXACT []
synonym: "phosphatidic acid formation" EXACT []
synonym: "phosphatidic acid synthesis" EXACT []
is_a: GO:0046473 ! phosphatidic acid metabolic process
is_a: GO:0046474 ! glycerophospholipid biosynthetic process

[Term]
id: GO:0006655
name: phosphatidylglycerol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol." [ISBN:0198506732]
subset: gosubset_prok
synonym: "phosphatidylglycerol anabolism" EXACT []
synonym: "phosphatidylglycerol biosynthesis" EXACT []
synonym: "phosphatidylglycerol formation" EXACT []
synonym: "phosphatidylglycerol synthesis" EXACT []
is_a: GO:0046471 ! phosphatidylglycerol metabolic process
is_a: GO:0046474 ! glycerophospholipid biosynthetic process

[Term]
id: GO:0006656
name: phosphatidylcholine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline." [ISBN:0198506732]
subset: gosubset_prok
synonym: "phosphatidylcholine anabolism" EXACT []
synonym: "phosphatidylcholine biosynthesis" EXACT []
synonym: "phosphatidylcholine formation" EXACT []
synonym: "phosphatidylcholine synthesis" EXACT []
is_a: GO:0046165 ! alcohol biosynthetic process
is_a: GO:0046470 ! phosphatidylcholine metabolic process
is_a: GO:0046474 ! glycerophospholipid biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process

[Term]
id: GO:0006657
name: CDP-choline pathway
namespace: biological_process
def: "The phosphatidylcholine biosynthetic process that begins with the phosphorylation of choline and ends with the combination of CDP-choline with diacylglycerol to form phosphatidylcholine." [ISBN:0471331309, MetaCyc:PWY3O-450]
subset: gosubset_prok
synonym: "Kennedy pathway" EXACT [MetaCyc:PWY3O-450]
synonym: "phosphatidylcholine biosynthesis from choline" EXACT [GOC:mah, MetaCyc:PWY3O-450]
xref: MetaCyc:PWY3O-450
is_a: GO:0006656 ! phosphatidylcholine biosynthetic process

[Term]
id: GO:0006658
name: phosphatidylserine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. They are important constituents of cell membranes." [ISBN:0198506732]
subset: gosubset_prok
synonym: "phosphatidylserine metabolism" EXACT []
is_a: GO:0006575 ! cellular modified amino acid metabolic process
is_a: GO:0006650 ! glycerophospholipid metabolic process
is_a: GO:0052646 ! alditol phosphate metabolic process

[Term]
id: GO:0006659
name: phosphatidylserine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine." [ISBN:0198506732]
subset: gosubset_prok
synonym: "phosphatidylserine anabolism" EXACT []
synonym: "phosphatidylserine biosynthesis" EXACT []
synonym: "phosphatidylserine formation" EXACT []
synonym: "phosphatidylserine synthesis" EXACT []
is_a: GO:0006658 ! phosphatidylserine metabolic process
is_a: GO:0042398 ! cellular modified amino acid biosynthetic process
is_a: GO:0046474 ! glycerophospholipid biosynthetic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process

[Term]
id: GO:0006660
name: phosphatidylserine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine." [ISBN:0198506732]
subset: gosubset_prok
synonym: "phosphatidylserine breakdown" EXACT []
synonym: "phosphatidylserine catabolism" EXACT []
synonym: "phosphatidylserine degradation" EXACT []
is_a: GO:0006658 ! phosphatidylserine metabolic process
is_a: GO:0042219 ! cellular modified amino acid catabolic process
is_a: GO:0046475 ! glycerophospholipid catabolic process
is_a: GO:1901136 ! carbohydrate derivative catabolic process
is_a: GO:1901606 ! alpha-amino acid catabolic process

[Term]
id: GO:0006661
name: phosphatidylinositol biosynthetic process
namespace: biological_process
alt_id: GO:0046489
def: "The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [CHEBI:28874, ISBN:0198506732]
subset: gosubset_prok
synonym: "phosphatidylinositol anabolism" EXACT []
synonym: "phosphatidylinositol biosynthesis" EXACT []
synonym: "phosphatidylinositol formation" EXACT []
synonym: "phosphatidylinositol synthesis" EXACT []
synonym: "phosphoinositide biosynthesis" EXACT []
synonym: "phosphoinositide biosynthetic process" EXACT []
synonym: "PtdIns biosynthesis" EXACT []
synonym: "PtdIns biosynthetic process" EXACT []
is_a: GO:0046474 ! glycerophospholipid biosynthetic process
is_a: GO:0046488 ! phosphatidylinositol metabolic process

[Term]
id: GO:0006662
name: glycerol ether metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol." [GOC:ai, ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
synonym: "glycerol ether metabolism" EXACT []
is_a: GO:0018904 ! ether metabolic process

[Term]
id: GO:0006663
name: platelet activating factor biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of platelet activating factor, 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphocholine, where alkyl = hexadecyl or octadecyl. Platelet activating factor is an inflammatory mediator released from a variety of cells in response to various stimuli." [ISBN:0198547684]
synonym: "PAF biosynthesis" EXACT []
synonym: "PAF biosynthetic process" EXACT []
synonym: "platelet activating factor anabolism" EXACT []
synonym: "platelet activating factor biosynthesis" EXACT []
synonym: "platelet activating factor formation" EXACT []
synonym: "platelet activating factor synthesis" EXACT []
is_a: GO:0046165 ! alcohol biosynthetic process
is_a: GO:0046469 ! platelet activating factor metabolic process
is_a: GO:0046474 ! glycerophospholipid biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process

[Term]
id: GO:0006664
name: glycolipid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycolipids, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). Some substances classified as bacterial glycolipids have the sugar group acylated by one or more fatty acids and the glycerol group may be absent." [CHEBI:33563, ISBN:0198547684]
subset: gosubset_prok
synonym: "glycolipid metabolism" EXACT []
is_a: GO:0006643 ! membrane lipid metabolic process
is_a: GO:1903509 ! liposaccharide metabolic process

[Term]
id: GO:0006665
name: sphingolipid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732]
subset: gosubset_prok
synonym: "sphingolipid metabolism" EXACT []
xref: Reactome:REACT_108332 "Sphingolipid metabolism, Rattus norvegicus"
xref: Reactome:REACT_110134 "Sphingolipid metabolism, Dictyostelium discoideum"
xref: Reactome:REACT_110621 "Sphingolipid metabolism, Danio rerio"
xref: Reactome:REACT_112370 "Sphingolipid metabolism, Escherichia coli"
xref: Reactome:REACT_116113 "Sphingolipid metabolism, Gallus gallus"
xref: Reactome:REACT_19323 "Sphingolipid metabolism, Homo sapiens"
xref: Reactome:REACT_29407 "Sphingolipid metabolism, Saccharomyces cerevisiae"
xref: Reactome:REACT_32308 "Sphingolipid metabolism, Canis familiaris"
xref: Reactome:REACT_32725 "Sphingolipid metabolism, Mycobacterium tuberculosis"
xref: Reactome:REACT_33480 "Sphingolipid metabolism, Plasmodium falciparum"
xref: Reactome:REACT_34763 "Sphingolipid metabolism, Xenopus tropicalis"
xref: Reactome:REACT_79250 "Sphingolipid metabolism, Schizosaccharomyces pombe"
xref: Reactome:REACT_82238 "Sphingolipid metabolism, Taeniopygia guttata"
xref: Reactome:REACT_83895 "Sphingolipid metabolism, Caenorhabditis elegans"
xref: Reactome:REACT_86205 "Sphingolipid metabolism, Bos taurus"
xref: Reactome:REACT_87089 "Sphingolipid metabolism, Oryza sativa"
xref: Reactome:REACT_87651 "Sphingolipid metabolism, Gallus gallus"
xref: Reactome:REACT_93322 "Sphingolipid metabolism, Arabidopsis thaliana"
xref: Reactome:REACT_93578 "Sphingolipid metabolism, Drosophila melanogaster"
xref: Reactome:REACT_94320 "Sphingolipid metabolism, Mus musculus"
xref: Reactome:REACT_97883 "Sphingolipid metabolism, Sus scrofa"
is_a: GO:0006643 ! membrane lipid metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process

[Term]
id: GO:0006666
name: 3-keto-sphinganine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 3-keto-sphinganine, a derivative of sphinganine with a ketone group at C3. It is an intermediate in the synthesis of sphingosine." [GOC:ai]
subset: gosubset_prok
synonym: "3-keto-dihydrosphingosine metabolic process" EXACT []
synonym: "3-keto-dihydrosphingosine metabolism" EXACT []
synonym: "3-keto-sphinganine metabolism" EXACT []
is_a: GO:0042180 ! cellular ketone metabolic process
is_a: GO:0046519 ! sphingoid metabolic process

[Term]
id: GO:0006667
name: sphinganine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sphinganine, D-erythro-2-amino-1,3-octadecanediol." [http://www.chem.qmul.ac.uk/iupac/lipid/lip1n2.html#p18]
subset: gosubset_prok
synonym: "dihydrosphingosine metabolic process" EXACT []
synonym: "dihydrosphingosine metabolism" EXACT []
synonym: "sphinganine metabolism" EXACT []
is_a: GO:0034311 ! diol metabolic process
is_a: GO:0046519 ! sphingoid metabolic process
is_a: GO:0097164 ! ammonium ion metabolic process

[Term]
id: GO:0006668
name: sphinganine-1-phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sphinganine-1-phosphate, the phosphorylated derivative of D-erythro-2-amino-1,3-octadecanediol." [GOC:ai]
subset: gosubset_prok
synonym: "dihydrosphingosine-1-phosphate metabolic process" EXACT []
synonym: "dihydrosphingosine-1-phosphate metabolism" EXACT []
synonym: "sphinganine-1-phosphate metabolism" EXACT []
is_a: GO:0006644 ! phospholipid metabolic process
is_a: GO:0006665 ! sphingolipid metabolic process

[Term]
id: GO:0006669
name: sphinganine-1-phosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sphinganine-1-phosphate, the phosphorylated derivative of D-erythro-2-amino-1,3-octadecanediol." [GOC:ai]
subset: gosubset_prok
synonym: "dihydrosphingosine-1-phosphate biosynthesis" EXACT []
synonym: "dihydrosphingosine-1-phosphate biosynthetic process" EXACT []
synonym: "sphinganine-1-phosphate anabolism" EXACT []
synonym: "sphinganine-1-phosphate biosynthesis" EXACT []
synonym: "sphinganine-1-phosphate formation" EXACT []
synonym: "sphinganine-1-phosphate synthesis" EXACT []
is_a: GO:0006668 ! sphinganine-1-phosphate metabolic process
is_a: GO:0008654 ! phospholipid biosynthetic process
is_a: GO:0030148 ! sphingolipid biosynthetic process

[Term]
id: GO:0006670
name: sphingosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues." [GOC:ma, ISBN:0198506732]
subset: gosubset_prok
synonym: "(4E)-sphing-4-enine metabolic process" EXACT []
synonym: "(4E)-sphing-4-enine metabolism" EXACT []
synonym: "sphing-4-enine metabolic process" EXACT []
synonym: "sphing-4-enine metabolism" EXACT []
synonym: "sphingosine metabolism" EXACT []
is_a: GO:0034311 ! diol metabolic process
is_a: GO:0046519 ! sphingoid metabolic process
is_a: GO:0097164 ! ammonium ion metabolic process

[Term]
id: GO:0006671
name: phytosphingosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phytosphingosine, (2S,3S,4R)-2-aminooctadecane-1,3,4-triol, a constituent of many plant sphingolipids." [CHEBI:46961, ISBN:0198506732]
subset: gosubset_prok
synonym: "phytosphingosine metabolism" EXACT []
is_a: GO:0019751 ! polyol metabolic process
is_a: GO:0046519 ! sphingoid metabolic process
is_a: GO:0097164 ! ammonium ion metabolic process

[Term]
id: GO:0006672
name: ceramide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ceramides, any N-acylated sphingoid." [ISBN:0198547684]
subset: gosubset_prok
synonym: "ceramide metabolism" EXACT []
is_a: GO:0006665 ! sphingolipid metabolic process
is_a: GO:0043603 ! cellular amide metabolic process

[Term]
id: GO:0006673
name: inositolphosphoceramide metabolic process
namespace: biological_process
alt_id: GO:0006674
def: "The chemical reactions and pathways involving inositolphosphoceramides, any lipid with a phosphodiester bridge between an inositol residue and the ceramide group." [http://www.chem.qmul.ac.uk/iupac/misc/glylp.html]
subset: gosubset_prok
synonym: "inositol phosphorylceramide metabolic process" EXACT []
synonym: "inositol phosphorylceramide metabolism" EXACT []
synonym: "inositolphosphoceramide metabolism" EXACT []
is_a: GO:0006644 ! phospholipid metabolic process
is_a: GO:0006665 ! sphingolipid metabolic process

[Term]
id: GO:0006675
name: mannosyl-inositol phosphorylceramide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mannosyl-inositol phosphorylceramide, any lipid with a phosphodiester bridge between an inositol residue and the ceramide group which contains a phosphoryl (-P(O)=) groups and a mannose derivative." [GOC:ai, MetaCyc:MIPC]
subset: gosubset_prok
synonym: "mannose inositol phosphoceramide metabolic process" EXACT []
synonym: "mannose inositol phosphoceramide metabolism" EXACT []
synonym: "mannose-inositol-P-ceramide (MIPC) metabolic process" EXACT []
synonym: "mannose-inositol-P-ceramide (MIPC) metabolism" EXACT []
synonym: "mannosyl-inositol-phosphorylceramide metabolism" EXACT []
synonym: "MIPC metabolic process" EXACT []
synonym: "MIPC metabolism" EXACT []
is_a: GO:0006673 ! inositolphosphoceramide metabolic process
is_a: GO:0006687 ! glycosphingolipid metabolic process

[Term]
id: GO:0006676
name: mannosyl diphosphorylinositol ceramide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mannosyl diphosphorylinositol ceramide, any lipid with a phosphodiester bridge between an inositol residue and the ceramide group which contains two phosphoryl (-P(O)=) groups and a mannose derivative." [GOC:ai]
subset: gosubset_prok
synonym: "M(IP)2C metabolic process" EXACT []
synonym: "M(IP)2C metabolism" EXACT []
synonym: "mannosyl diphosphorylinositol ceramide metabolism" EXACT []
is_a: GO:0006505 ! GPI anchor metabolic process
is_a: GO:0006673 ! inositolphosphoceramide metabolic process

[Term]
id: GO:0006677
name: glycosylceramide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of a monosaccharide (or derivative) by a ceramide group." [GOC:ai, ISBN:0198506732]
subset: gosubset_prok
synonym: "glycosylceramide metabolism" EXACT []
is_a: GO:0006672 ! ceramide metabolic process
is_a: GO:0006687 ! glycosphingolipid metabolic process

[Term]
id: GO:0006678
name: glucosylceramide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group. They are neutral glycolipids containing equimolar amounts of fatty acid, glucose, and sphingosine or a sphingosine derivative." [CHEBI:36500, GOC:curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "glucosylceramide metabolism" EXACT []
is_a: GO:0006677 ! glycosylceramide metabolic process

[Term]
id: GO:0006679
name: glucosylceramide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group." [GOC:ai]
subset: gosubset_prok
synonym: "glucosylceramide anabolism" EXACT []
synonym: "glucosylceramide biosynthesis" EXACT []
synonym: "glucosylceramide formation" EXACT []
synonym: "glucosylceramide synthesis" EXACT []
is_a: GO:0006678 ! glucosylceramide metabolic process
is_a: GO:0046476 ! glycosylceramide biosynthetic process

[Term]
id: GO:0006680
name: glucosylceramide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group." [GOC:ai]
subset: gosubset_prok
synonym: "glucosylceramide breakdown" EXACT []
synonym: "glucosylceramide catabolism" EXACT []
synonym: "glucosylceramide degradation" EXACT []
is_a: GO:0006678 ! glucosylceramide metabolic process
is_a: GO:0046477 ! glycosylceramide catabolic process

[Term]
id: GO:0006681
name: galactosylceramide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group." [GOC:ai]
subset: gosubset_prok
synonym: "galactosylceramide metabolism" EXACT []
is_a: GO:0006677 ! glycosylceramide metabolic process
is_a: GO:0019374 ! galactolipid metabolic process

[Term]
id: GO:0006682
name: galactosylceramide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group." [GOC:ai]
subset: gosubset_prok
synonym: "galactosylceramide anabolism" EXACT []
synonym: "galactosylceramide biosynthesis" EXACT []
synonym: "galactosylceramide formation" EXACT []
synonym: "galactosylceramide synthesis" EXACT []
is_a: GO:0006681 ! galactosylceramide metabolic process
is_a: GO:0019375 ! galactolipid biosynthetic process
is_a: GO:0046476 ! glycosylceramide biosynthetic process

[Term]
id: GO:0006683
name: galactosylceramide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group." [GOC:ai]
subset: gosubset_prok
synonym: "galactosylceramide breakdown" EXACT []
synonym: "galactosylceramide catabolism" EXACT []
synonym: "galactosylceramide degradation" EXACT []
is_a: GO:0006681 ! galactosylceramide metabolic process
is_a: GO:0019376 ! galactolipid catabolic process
is_a: GO:0046477 ! glycosylceramide catabolic process

[Term]
id: GO:0006684
name: sphingomyelin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine, any of a class of phospholipids in which the amino group of sphingosine is in amide linkage with one of several fatty acids, while the terminal hydroxyl group of sphingosine is esterified to phosphorylcholine." [ISBN:0198506732]
subset: gosubset_prok
synonym: "sphingomyelin metabolism" EXACT []
is_a: GO:0006644 ! phospholipid metabolic process
is_a: GO:0006665 ! sphingolipid metabolic process
is_a: GO:0042439 ! ethanolamine-containing compound metabolic process
is_a: GO:0043603 ! cellular amide metabolic process
is_a: GO:0097164 ! ammonium ion metabolic process

[Term]
id: GO:0006685
name: sphingomyelin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine." [ISBN:0198506732]
subset: gosubset_prok
synonym: "sphingomyelin breakdown" EXACT []
synonym: "sphingomyelin catabolism" EXACT []
synonym: "sphingomyelin degradation" EXACT []
is_a: GO:0006684 ! sphingomyelin metabolic process
is_a: GO:0009395 ! phospholipid catabolic process
is_a: GO:0030149 ! sphingolipid catabolic process
is_a: GO:0046164 ! alcohol catabolic process

[Term]
id: GO:0006686
name: sphingomyelin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine." [ISBN:0198506732]
subset: gosubset_prok
synonym: "sphingomyelin anabolism" EXACT []
synonym: "sphingomyelin biosynthesis" EXACT []
synonym: "sphingomyelin formation" EXACT []
synonym: "sphingomyelin synthesis" EXACT []
is_a: GO:0006684 ! sphingomyelin metabolic process
is_a: GO:0008654 ! phospholipid biosynthetic process
is_a: GO:0030148 ! sphingolipid biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process
is_a: GO:0046165 ! alcohol biosynthetic process

[Term]
id: GO:0006687
name: glycosphingolipid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycosphingolipids, any compound with residues of sphingoid and at least one monosaccharide." [ISBN:0198547684]
subset: gosubset_prok
synonym: "glycosphingolipid metabolism" EXACT []
xref: Reactome:REACT_116105 "Glycosphingolipid metabolism, Homo sapiens"
is_a: GO:0006664 ! glycolipid metabolic process
is_a: GO:0006665 ! sphingolipid metabolic process

[Term]
id: GO:0006688
name: glycosphingolipid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide." [GOC:go_curators]
subset: gosubset_prok
synonym: "glycosphingolipid anabolism" EXACT []
synonym: "glycosphingolipid biosynthesis" EXACT []
synonym: "glycosphingolipid formation" EXACT []
synonym: "glycosphingolipid synthesis" EXACT []
is_a: GO:0006687 ! glycosphingolipid metabolic process
is_a: GO:0009247 ! glycolipid biosynthetic process
is_a: GO:0030148 ! sphingolipid biosynthetic process

[Term]
id: GO:0006689
name: ganglioside catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ganglioside, a ceramide oligosaccharide carrying, in addition to other sugar residues, one or more sialic residues." [ISBN:0198547684]
subset: gosubset_prok
synonym: "ganglioside breakdown" EXACT []
synonym: "ganglioside catabolism" EXACT []
synonym: "ganglioside degradation" EXACT []
is_a: GO:0001573 ! ganglioside metabolic process
is_a: GO:0046479 ! glycosphingolipid catabolic process
is_a: GO:0046514 ! ceramide catabolic process

[Term]
id: GO:0006690
name: icosanoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving icosanoids, any of a group of C20 polyunsaturated fatty acids." [GOC:ma]
subset: gosubset_prok
synonym: "eicosanoid metabolic process" EXACT []
synonym: "eicosanoid metabolism" EXACT []
synonym: "icosanoid metabolism" EXACT []
xref: Reactome:REACT_100646 "Eicosanoids, Sus scrofa"
xref: Reactome:REACT_104266 "Eicosanoids, Danio rerio"
xref: Reactome:REACT_108754 "Eicosanoids, Gallus gallus"
xref: Reactome:REACT_112473 "Eicosanoids, Oryza sativa"
xref: Reactome:REACT_114020 "Eicosanoids, Dictyostelium discoideum"
xref: Reactome:REACT_114104 "Eicosanoids, Arabidopsis thaliana"
xref: Reactome:REACT_114508 "Eicosanoids, Mycobacterium tuberculosis"
xref: Reactome:REACT_13645 "Eicosanoids, Homo sapiens"
xref: Reactome:REACT_28690 "Eicosanoids, Bos taurus"
xref: Reactome:REACT_81451 "Eicosanoids, Taeniopygia guttata"
xref: Reactome:REACT_85792 "Eicosanoids, Rattus norvegicus"
xref: Reactome:REACT_87093 "Eicosanoids, Mus musculus"
xref: Reactome:REACT_98517 "Eicosanoids, Xenopus tropicalis"
xref: Reactome:REACT_99692 "Eicosanoids, Canis familiaris"
is_a: GO:0019752 ! carboxylic acid metabolic process
is_a: GO:1901568 ! fatty acid derivative metabolic process

[Term]
id: GO:0006691
name: leukotriene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid." [GOC:ma]
subset: gosubset_prok
synonym: "leukotriene metabolism" EXACT []
is_a: GO:0006690 ! icosanoid metabolic process
is_a: GO:0033559 ! unsaturated fatty acid metabolic process

[Term]
id: GO:0006692
name: prostanoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving prostanoids, any compound based on or derived from the prostanoate structure." [ISBN:0198506732]
subset: gosubset_prok
synonym: "prostanoid metabolism" EXACT []
xref: Reactome:REACT_100061 "Prostanoid metabolism, Rattus norvegicus"
xref: Reactome:REACT_101975 "Prostanoid metabolism, Arabidopsis thaliana"
xref: Reactome:REACT_102782 "Prostanoid metabolism, Danio rerio"
xref: Reactome:REACT_105826 "Prostanoid metabolism, Canis familiaris"
xref: Reactome:REACT_107008 "Prostanoid metabolism, Bos taurus"
xref: Reactome:REACT_108036 "Prostanoid metabolism, Mus musculus"
xref: Reactome:REACT_108685 "Prostanoid metabolism, Xenopus tropicalis"
xref: Reactome:REACT_110738 "Prostanoid metabolism, Sus scrofa"
xref: Reactome:REACT_113225 "Prostanoid metabolism, Mycobacterium tuberculosis"
xref: Reactome:REACT_15369 "Prostanoid metabolism, Homo sapiens"
xref: Reactome:REACT_33189 "Prostanoid metabolism, Dictyostelium discoideum"
xref: Reactome:REACT_78452 "Prostanoid metabolism, Caenorhabditis elegans"
xref: Reactome:REACT_83488 "Prostanoid metabolism, Schizosaccharomyces pombe"
xref: Reactome:REACT_86942 "Prostanoid metabolism, Gallus gallus"
xref: Reactome:REACT_90055 "Prostanoid metabolism, Plasmodium falciparum"
xref: Reactome:REACT_92504 "Prostanoid metabolism, Drosophila melanogaster"
xref: Reactome:REACT_92842 "Prostanoid metabolism, Oryza sativa"
xref: Reactome:REACT_93525 "Prostanoid metabolism, Escherichia coli"
xref: Reactome:REACT_96108 "Prostanoid metabolism, Taeniopygia guttata"
xref: Reactome:REACT_96690 "Prostanoid metabolism, Saccharomyces cerevisiae"
is_a: GO:0006690 ! icosanoid metabolic process
is_a: GO:0033559 ! unsaturated fatty acid metabolic process

[Term]
id: GO:0006693
name: prostaglandin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities." [ISBN:0198506732]
subset: gosubset_prok
synonym: "prostaglandin metabolism" EXACT []
is_a: GO:0006692 ! prostanoid metabolic process

[Term]
id: GO:0006694
name: steroid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification." [GOC:go_curators]
subset: gosubset_prok
synonym: "steroid anabolism" EXACT []
synonym: "steroid biosynthesis" EXACT []
synonym: "steroid formation" EXACT []
synonym: "steroid synthesis" EXACT []
synonym: "steroidogenesis" EXACT []
xref: Wikipedia:Steroid_metabolisms#Steroid_biosynthesis
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:0008610 ! lipid biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process

[Term]
id: GO:0006695
name: cholesterol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:ai]
synonym: "cholesterol anabolism" EXACT []
synonym: "cholesterol biosynthesis" EXACT []
synonym: "cholesterol formation" EXACT []
synonym: "cholesterol synthesis" EXACT []
xref: Reactome:REACT_102561 "Cholesterol biosynthesis, Saccharomyces cerevisiae"
xref: Reactome:REACT_102893 "Cholesterol biosynthesis, Rattus norvegicus"
xref: Reactome:REACT_103731 "Cholesterol biosynthesis, Gallus gallus"
xref: Reactome:REACT_104563 "Cholesterol biosynthesis, Xenopus tropicalis"
xref: Reactome:REACT_105508 "Cholesterol biosynthesis, Schizosaccharomyces pombe"
xref: Reactome:REACT_105624 "Cholesterol biosynthesis, Danio rerio"
xref: Reactome:REACT_106916 "Cholesterol biosynthesis, Dictyostelium discoideum"
xref: Reactome:REACT_107533 "Cholesterol biosynthesis, Bos taurus"
xref: Reactome:REACT_30189 "Cholesterol biosynthesis, Oryza sativa"
xref: Reactome:REACT_30476 "Cholesterol biosynthesis, Mus musculus"
xref: Reactome:REACT_32659 "Cholesterol biosynthesis, Escherichia coli"
xref: Reactome:REACT_34689 "Cholesterol biosynthesis, Plasmodium falciparum"
xref: Reactome:REACT_47814 "Cholesterol biosynthesis, Canis familiaris"
xref: Reactome:REACT_82467 "Cholesterol biosynthesis, Sus scrofa"
xref: Reactome:REACT_84026 "Cholesterol biosynthesis, Staphylococcus aureus N315"
xref: Reactome:REACT_91662 "Cholesterol biosynthesis, Arabidopsis thaliana"
xref: Reactome:REACT_92299 "Cholesterol biosynthesis, Caenorhabditis elegans"
xref: Reactome:REACT_9405 "Cholesterol biosynthesis, Homo sapiens"
xref: Reactome:REACT_94867 "Cholesterol biosynthesis, Drosophila melanogaster"
xref: Reactome:REACT_95230 "Cholesterol biosynthesis, Mycobacterium tuberculosis"
xref: Reactome:REACT_96989 "Cholesterol biosynthesis, Taeniopygia guttata"
is_a: GO:0008203 ! cholesterol metabolic process
is_a: GO:0016126 ! sterol biosynthetic process
is_a: GO:1902653 ! secondary alcohol biosynthetic process

[Term]
id: GO:0006696
name: ergosterol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds." [ISBN:0198506732]
subset: gosubset_prok
synonym: "ergosterol anabolism" EXACT []
synonym: "ergosterol biosynthesis" EXACT []
synonym: "ergosterol formation" EXACT []
synonym: "ergosterol synthesis" EXACT []
is_a: GO:0008204 ! ergosterol metabolic process
is_a: GO:0016126 ! sterol biosynthetic process
is_a: GO:0016129 ! phytosteroid biosynthetic process
is_a: GO:0044108 ! cellular alcohol biosynthetic process
is_a: GO:0097384 ! cellular lipid biosynthetic process
is_a: GO:1902653 ! secondary alcohol biosynthetic process

[Term]
id: GO:0006697
name: ecdysone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects." [ISBN:0198506732]
synonym: "ecdysone anabolism" EXACT []
synonym: "ecdysone biosynthesis" EXACT []
synonym: "ecdysone formation" EXACT []
synonym: "ecdysone synthesis" EXACT []
is_a: GO:0008205 ! ecdysone metabolic process
is_a: GO:0016126 ! sterol biosynthetic process
is_a: GO:0045456 ! ecdysteroid biosynthetic process
is_a: GO:1902653 ! secondary alcohol biosynthetic process

[Term]
id: GO:0006698
name: obsolete ecdysone modification
namespace: biological_process
def: "OBSOLETE. The covalent or conformational alteration of ecdysone, resulting in a change in its properties." [GOC:jl]
comment: This term was made obsolete because it was created to cover the conversion of ecdysone to its active form ecdysterone (20-hydroxyecdysone), but this reaction is carried out in a single step by ecdysone 20-monooxygenase (EC 1.14.99.22) and so is a function rather than a process.
synonym: "ecdysone modification" EXACT []
is_obsolete: true
replaced_by: GO:0004501

[Term]
id: GO:0006699
name: bile acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile." [GOC:go_curators]
synonym: "bile acid anabolism" EXACT []
synonym: "bile acid biosynthesis" EXACT []
synonym: "bile acid formation" EXACT []
synonym: "bile acid synthesis" EXACT []
xref: Reactome:REACT_100302 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol, Danio rerio"
xref: Reactome:REACT_100406 "Synthesis of bile acids and bile salts, Escherichia coli"
xref: Reactome:REACT_101474 "Synthesis of bile acids and bile salts, Caenorhabditis elegans"
xref: Reactome:REACT_102723 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol, Mus musculus"
xref: Reactome:REACT_102812 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol, Mus musculus"
xref: Reactome:REACT_103014 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol, Gallus gallus"
xref: Reactome:REACT_103176 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol, Taeniopygia guttata"
xref: Reactome:REACT_103419 "Synthesis of bile acids and bile salts, Rattus norvegicus"
xref: Reactome:REACT_103792 "Synthesis of bile acids and bile salts, Saccharomyces cerevisiae"
xref: Reactome:REACT_104380 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol, Mycobacterium tuberculosis"
xref: Reactome:REACT_104939 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol, Canis familiaris"
xref: Reactome:REACT_105272 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol, Gallus gallus"
xref: Reactome:REACT_106240 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol, Sus scrofa"
xref: Reactome:REACT_108090 "Synthesis of bile acids and bile salts, Dictyostelium discoideum"
xref: Reactome:REACT_109346 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol, Xenopus tropicalis"
xref: Reactome:REACT_11041 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol, Homo sapiens"
xref: Reactome:REACT_11048 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol, Homo sapiens"
xref: Reactome:REACT_11053 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol, Homo sapiens"
xref: Reactome:REACT_11054 "Synthesis of bile acids and bile salts, Homo sapiens"
xref: Reactome:REACT_110885 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol, Taeniopygia guttata"
xref: Reactome:REACT_112535 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol, Dictyostelium discoideum"
xref: Reactome:REACT_113154 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol, Oryza sativa"
xref: Reactome:REACT_113534 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol, Mycobacterium tuberculosis"
xref: Reactome:REACT_113599 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol, Oryza sativa"
xref: Reactome:REACT_113889 "Synthesis of bile acids and bile salts, Plasmodium falciparum"
xref: Reactome:REACT_114349 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol, Arabidopsis thaliana"
xref: Reactome:REACT_114625 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol, Dictyostelium discoideum"
xref: Reactome:REACT_114646 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol, Plasmodium falciparum"
xref: Reactome:REACT_28083 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol, Arabidopsis thaliana"
xref: Reactome:REACT_28270 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol, Caenorhabditis elegans"
xref: Reactome:REACT_30249 "Synthesis of bile acids and bile salts, Drosophila melanogaster"
xref: Reactome:REACT_30307 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol, Bos taurus"
xref: Reactome:REACT_30515 "Synthesis of bile acids and bile salts, Xenopus tropicalis"
xref: Reactome:REACT_30876 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol, Escherichia coli"
xref: Reactome:REACT_31948 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol, Danio rerio"
xref: Reactome:REACT_33968 "Synthesis of bile acids and bile salts, Sus scrofa"
xref: Reactome:REACT_77225 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol, Sus scrofa"
xref: Reactome:REACT_77449 "Synthesis of bile acids and bile salts, Mus musculus"
xref: Reactome:REACT_77758 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol, Saccharomyces cerevisiae"
xref: Reactome:REACT_77759 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol, Bos taurus"
xref: Reactome:REACT_78965 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol, Rattus norvegicus"
xref: Reactome:REACT_79374 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol, Taeniopygia guttata"
xref: Reactome:REACT_79993 "Synthesis of bile acids and bile salts, Bos taurus"
xref: Reactome:REACT_80067 "Synthesis of bile acids and bile salts, Danio rerio"
xref: Reactome:REACT_80599 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol, Schizosaccharomyces pombe"
xref: Reactome:REACT_81858 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol, Drosophila melanogaster"
xref: Reactome:REACT_82827 "Synthesis of bile acids and bile salts, Schizosaccharomyces pombe"
xref: Reactome:REACT_82865 "Synthesis of bile acids and bile salts, Arabidopsis thaliana"
xref: Reactome:REACT_84593 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol, Rattus norvegicus"
xref: Reactome:REACT_86732 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol, Xenopus tropicalis"
xref: Reactome:REACT_87331 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol, Mus musculus"
xref: Reactome:REACT_87625 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol, Arabidopsis thaliana"
xref: Reactome:REACT_87652 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol, Escherichia coli"
xref: Reactome:REACT_88203 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol, Canis familiaris"
xref: Reactome:REACT_88402 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol, Dictyostelium discoideum"
xref: Reactome:REACT_88445 "Synthesis of bile acids and bile salts, Canis familiaris"
xref: Reactome:REACT_88895 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol, Bos taurus"
xref: Reactome:REACT_91990 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol, Gallus gallus"
xref: Reactome:REACT_92118 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol, Sus scrofa"
xref: Reactome:REACT_93400 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol, Canis familiaris"
xref: Reactome:REACT_93700 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol, Escherichia coli"
xref: Reactome:REACT_94166 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol, Saccharomyces cerevisiae"
xref: Reactome:REACT_94950 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol, Xenopus tropicalis"
xref: Reactome:REACT_95225 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol, Drosophila melanogaster"
xref: Reactome:REACT_95248 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol, Rattus norvegicus"
xref: Reactome:REACT_95486 "Synthesis of bile acids and bile salts, Taeniopygia guttata"
xref: Reactome:REACT_95816 "Synthesis of bile acids and bile salts, Mycobacterium tuberculosis"
xref: Reactome:REACT_96568 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol, Caenorhabditis elegans"
xref: Reactome:REACT_96571 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol, Oryza sativa"
xref: Reactome:REACT_96665 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol, Drosophila melanogaster"
xref: Reactome:REACT_97113 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol, Mycobacterium tuberculosis"
xref: Reactome:REACT_98081 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol, Saccharomyces cerevisiae"
xref: Reactome:REACT_98840 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol, Danio rerio"
xref: Reactome:REACT_99028 "Synthesis of bile acids and bile salts, Gallus gallus"
xref: Reactome:REACT_99724 "Synthesis of bile acids and bile salts, Oryza sativa"
is_a: GO:0006694 ! steroid biosynthetic process
is_a: GO:0008206 ! bile acid metabolic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process

[Term]
id: GO:0006700
name: C21-steroid hormone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones." [GOC:ai]
synonym: "C21-steroid hormone anabolism" EXACT []
synonym: "C21-steroid hormone biosynthesis" EXACT []
synonym: "C21-steroid hormone formation" EXACT []
synonym: "C21-steroid hormone synthesis" EXACT []
xref: Reactome:REACT_100114 "Pregnenolone biosynthesis, Bos taurus"
xref: Reactome:REACT_107086 "Pregnenolone biosynthesis, Danio rerio"
xref: Reactome:REACT_11038 "Pregnenolone biosynthesis, Homo sapiens"
xref: Reactome:REACT_113158 "Pregnenolone biosynthesis, Dictyostelium discoideum"
xref: Reactome:REACT_115282 "Pregnenolone biosynthesis, Oryza sativa"
xref: Reactome:REACT_115412 "Pregnenolone biosynthesis, Arabidopsis thaliana"
xref: Reactome:REACT_32512 "Pregnenolone biosynthesis, Drosophila melanogaster"
xref: Reactome:REACT_79584 "Pregnenolone biosynthesis, Taeniopygia guttata"
xref: Reactome:REACT_81844 "Pregnenolone biosynthesis, Gallus gallus"
xref: Reactome:REACT_85889 "Pregnenolone biosynthesis, Caenorhabditis elegans"
xref: Reactome:REACT_86180 "Pregnenolone biosynthesis, Xenopus tropicalis"
xref: Reactome:REACT_89702 "Pregnenolone biosynthesis, Rattus norvegicus"
xref: Reactome:REACT_91740 "Pregnenolone biosynthesis, Saccharomyces cerevisiae"
xref: Reactome:REACT_91942 "Pregnenolone biosynthesis, Mus musculus"
xref: Reactome:REACT_96917 "Pregnenolone biosynthesis, Sus scrofa"
xref: Reactome:REACT_98782 "Pregnenolone biosynthesis, Canis familiaris"
is_a: GO:0006694 ! steroid biosynthetic process
is_a: GO:0008207 ! C21-steroid hormone metabolic process
is_a: GO:0042446 ! hormone biosynthetic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0006701
name: progesterone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants." [GOC:jl, http://www.cogsci.princeton.edu/]
synonym: "progesterone anabolism" EXACT []
synonym: "progesterone biosynthesis" EXACT []
synonym: "progesterone formation" EXACT []
synonym: "progesterone synthesis" EXACT []
is_a: GO:0006700 ! C21-steroid hormone biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0042448 ! progesterone metabolic process

[Term]
id: GO:0006702
name: androgen biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics." [ISBN:0198506732]
synonym: "androgen anabolism" EXACT []
synonym: "androgen biosynthesis" EXACT []
synonym: "androgen formation" EXACT []
synonym: "androgen synthesis" EXACT []
xref: Reactome:REACT_102314 "Androgen biosynthesis, Taeniopygia guttata"
xref: Reactome:REACT_105699 "Androgen biosynthesis, Arabidopsis thaliana"
xref: Reactome:REACT_105813 "Androgen biosynthesis, Sus scrofa"
xref: Reactome:REACT_110320 "Androgen biosynthesis, Oryza sativa"
xref: Reactome:REACT_11059 "Androgen biosynthesis, Homo sapiens"
xref: Reactome:REACT_112163 "Androgen biosynthesis, Escherichia coli"
xref: Reactome:REACT_112753 "Androgen biosynthesis, Mycobacterium tuberculosis"
xref: Reactome:REACT_31255 "Androgen biosynthesis, Canis familiaris"
xref: Reactome:REACT_31731 "Androgen biosynthesis, Drosophila melanogaster"
xref: Reactome:REACT_32074 "Androgen biosynthesis, Schizosaccharomyces pombe"
xref: Reactome:REACT_33719 "Androgen biosynthesis, Plasmodium falciparum"
xref: Reactome:REACT_77502 "Androgen biosynthesis, Xenopus tropicalis"
xref: Reactome:REACT_81567 "Androgen biosynthesis, Bos taurus"
xref: Reactome:REACT_82592 "Androgen biosynthesis, Gallus gallus"
xref: Reactome:REACT_83836 "Androgen biosynthesis, Mus musculus"
xref: Reactome:REACT_93760 "Androgen biosynthesis, Danio rerio"
xref: Reactome:REACT_95083 "Androgen biosynthesis, Rattus norvegicus"
xref: Reactome:REACT_97388 "Androgen biosynthesis, Saccharomyces cerevisiae"
xref: Reactome:REACT_98944 "Androgen biosynthesis, Dictyostelium discoideum"
is_a: GO:0006694 ! steroid biosynthetic process
is_a: GO:0008209 ! androgen metabolic process
is_a: GO:0042446 ! hormone biosynthetic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0006703
name: estrogen biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants." [ISBN:0198506732]
synonym: "estrogen anabolism" EXACT []
synonym: "estrogen biosynthesis" EXACT []
synonym: "estrogen formation" EXACT []
synonym: "estrogen synthesis" EXACT []
synonym: "oestrogen biosynthesis" EXACT []
synonym: "oestrogen biosynthetic process" EXACT []
xref: Reactome:REACT_101607 "Estrogen biosynthesis, Bos taurus"
xref: Reactome:REACT_104439 "Estrogen biosynthesis, Taeniopygia guttata"
xref: Reactome:REACT_109509 "Estrogen biosynthesis, Danio rerio"
xref: Reactome:REACT_11037 "Estrogen biosynthesis, Homo sapiens"
xref: Reactome:REACT_25243 "Estrone is hydrogenated to estradiol, Homo sapiens"
xref: Reactome:REACT_32952 "Estrogen biosynthesis, Mus musculus"
xref: Reactome:REACT_82733 "Estrogen biosynthesis, Canis familiaris"
xref: Reactome:REACT_84542 "Estrogen biosynthesis, Rattus norvegicus"
xref: Reactome:REACT_93011 "Estrogen biosynthesis, Xenopus tropicalis"
xref: Reactome:REACT_95159 "Estrogen biosynthesis, Gallus gallus"
is_a: GO:0006694 ! steroid biosynthetic process
is_a: GO:0008210 ! estrogen metabolic process
is_a: GO:0042446 ! hormone biosynthetic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0006704
name: glucocorticoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol." [ISBN:0198506732]
synonym: "glucocorticoid anabolism" EXACT []
synonym: "glucocorticoid biosynthesis" EXACT []
synonym: "glucocorticoid formation" EXACT []
synonym: "glucocorticoid synthesis" EXACT []
xref: Reactome:REACT_100413 "Glucocorticoid biosynthesis, Sus scrofa"
xref: Reactome:REACT_101421 "Glucocorticoid biosynthesis, Dictyostelium discoideum"
xref: Reactome:REACT_102866 "Glucocorticoid biosynthesis, Rattus norvegicus"
xref: Reactome:REACT_107330 "Glucocorticoid biosynthesis, Xenopus tropicalis"
xref: Reactome:REACT_107450 "Glucocorticoid biosynthesis, Mus musculus"
xref: Reactome:REACT_107635 "Glucocorticoid biosynthesis, Canis familiaris"
xref: Reactome:REACT_108788 "Glucocorticoid biosynthesis, Mycobacterium tuberculosis"
xref: Reactome:REACT_11036 "Glucocorticoid biosynthesis, Homo sapiens"
xref: Reactome:REACT_112672 "Glucocorticoid biosynthesis, Plasmodium falciparum"
xref: Reactome:REACT_113066 "Glucocorticoid biosynthesis, Escherichia coli"
xref: Reactome:REACT_77995 "Glucocorticoid biosynthesis, Oryza sativa"
xref: Reactome:REACT_79303 "Glucocorticoid biosynthesis, Bos taurus"
xref: Reactome:REACT_84297 "Glucocorticoid biosynthesis, Danio rerio"
xref: Reactome:REACT_85887 "Glucocorticoid biosynthesis, Taeniopygia guttata"
xref: Reactome:REACT_86974 "Glucocorticoid biosynthesis, Drosophila melanogaster"
xref: Reactome:REACT_88537 "Glucocorticoid biosynthesis, Arabidopsis thaliana"
xref: Reactome:REACT_94676 "Glucocorticoid biosynthesis, Gallus gallus"
is_a: GO:0006694 ! steroid biosynthetic process
is_a: GO:0008211 ! glucocorticoid metabolic process

[Term]
id: GO:0006705
name: mineralocorticoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol." [ISBN:0198506732]
synonym: "mineralocorticoid anabolism" EXACT []
synonym: "mineralocorticoid biosynthesis" EXACT []
synonym: "mineralocorticoid formation" EXACT []
synonym: "mineralocorticoid synthesis" EXACT []
xref: Reactome:REACT_103517 "Mineralocorticoid biosynthesis, Mus musculus"
xref: Reactome:REACT_108854 "Mineralocorticoid biosynthesis, Gallus gallus"
xref: Reactome:REACT_109273 "Mineralocorticoid biosynthesis, Taeniopygia guttata"
xref: Reactome:REACT_11047 "Mineralocorticoid biosynthesis, Homo sapiens"
xref: Reactome:REACT_112957 "Mineralocorticoid biosynthesis, Escherichia coli"
xref: Reactome:REACT_113805 "Mineralocorticoid biosynthesis, Mycobacterium tuberculosis"
xref: Reactome:REACT_30217 "Mineralocorticoid biosynthesis, Bos taurus"
xref: Reactome:REACT_32293 "Mineralocorticoid biosynthesis, Xenopus tropicalis"
xref: Reactome:REACT_77462 "Mineralocorticoid biosynthesis, Rattus norvegicus"
xref: Reactome:REACT_86556 "Mineralocorticoid biosynthesis, Danio rerio"
xref: Reactome:REACT_88868 "Mineralocorticoid biosynthesis, Drosophila melanogaster"
xref: Reactome:REACT_94686 "Mineralocorticoid biosynthesis, Canis familiaris"
xref: Reactome:REACT_97241 "Mineralocorticoid biosynthesis, Sus scrofa"
is_a: GO:0006694 ! steroid biosynthetic process
is_a: GO:0008212 ! mineralocorticoid metabolic process
is_a: GO:0042446 ! hormone biosynthetic process

[Term]
id: GO:0006706
name: steroid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:go_curators]
subset: gosubset_prok
synonym: "steroid breakdown" EXACT []
synonym: "steroid catabolism" EXACT []
synonym: "steroid degradation" EXACT []
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:0016042 ! lipid catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process

[Term]
id: GO:0006707
name: cholesterol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:ai]
synonym: "cholesterol breakdown" EXACT []
synonym: "cholesterol catabolism" EXACT []
synonym: "cholesterol degradation" EXACT []
is_a: GO:0008203 ! cholesterol metabolic process
is_a: GO:0016127 ! sterol catabolic process

[Term]
id: GO:0006708
name: ecdysone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects." [ISBN:0198506732]
synonym: "ecdysone breakdown" EXACT []
synonym: "ecdysone catabolism" EXACT []
synonym: "ecdysone degradation" EXACT []
is_a: GO:0008205 ! ecdysone metabolic process
is_a: GO:0016127 ! sterol catabolic process
is_a: GO:0046344 ! ecdysteroid catabolic process

[Term]
id: GO:0006709
name: progesterone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants." [GOC:jl, http://www.cogsci.princeton.edu/]
synonym: "progesterone breakdown" EXACT []
synonym: "progesterone catabolism" EXACT []
synonym: "progesterone degradation" EXACT []
is_a: GO:0008208 ! C21-steroid hormone catabolic process
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:0042448 ! progesterone metabolic process

[Term]
id: GO:0006710
name: androgen catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics." [ISBN:0198506732]
synonym: "androgen breakdown" EXACT []
synonym: "androgen catabolism" EXACT []
synonym: "androgen degradation" EXACT []
is_a: GO:0006706 ! steroid catabolic process
is_a: GO:0008209 ! androgen metabolic process
is_a: GO:0042447 ! hormone catabolic process

[Term]
id: GO:0006711
name: estrogen catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants." [ISBN:0198506732]
subset: gosubset_prok
synonym: "estrogen breakdown" EXACT []
synonym: "estrogen catabolism" EXACT []
synonym: "estrogen degradation" EXACT []
synonym: "oestrogen catabolic process" EXACT []
synonym: "oestrogen catabolism" EXACT []
is_a: GO:0006706 ! steroid catabolic process
is_a: GO:0008210 ! estrogen metabolic process
is_a: GO:0042447 ! hormone catabolic process

[Term]
id: GO:0006712
name: mineralocorticoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol." [ISBN:0198506732]
synonym: "mineralocorticoid breakdown" EXACT []
synonym: "mineralocorticoid catabolism" EXACT []
synonym: "mineralocorticoid degradation" EXACT []
is_a: GO:0006706 ! steroid catabolic process
is_a: GO:0008212 ! mineralocorticoid metabolic process
is_a: GO:0042447 ! hormone catabolic process

[Term]
id: GO:0006713
name: glucocorticoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol." [ISBN:0198506732]
synonym: "glucocorticoid breakdown" EXACT []
synonym: "glucocorticoid catabolism" EXACT []
synonym: "glucocorticoid degradation" EXACT []
is_a: GO:0006706 ! steroid catabolic process
is_a: GO:0008211 ! glucocorticoid metabolic process

[Term]
id: GO:0006714
name: sesquiterpenoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sesquiterpenoid compounds, terpenoids with three isoprene units." [ISBN:0198547684]
subset: gosubset_prok
synonym: "sesquiterpenoid metabolism" EXACT []
is_a: GO:0006721 ! terpenoid metabolic process

[Term]
id: GO:0006715
name: farnesol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the sesquiterpenoid alcohol farnesol, 3,7,11-trimethyl-2,6,10,dodecatrien-1-ol." [ISBN:0198547684]
subset: gosubset_prok
synonym: "farnesol anabolism" EXACT []
synonym: "farnesol biosynthesis" EXACT []
synonym: "farnesol formation" EXACT []
synonym: "farnesol synthesis" EXACT []
is_a: GO:0016094 ! polyprenol biosynthetic process
is_a: GO:0016106 ! sesquiterpenoid biosynthetic process
is_a: GO:0016487 ! farnesol metabolic process
is_a: GO:0034309 ! primary alcohol biosynthetic process

[Term]
id: GO:0006716
name: juvenile hormone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:go_curators, ISBN:0198547684]
synonym: "juvenile hormone metabolism" EXACT []
is_a: GO:0006714 ! sesquiterpenoid metabolic process
is_a: GO:0034754 ! cellular hormone metabolic process

[Term]
id: GO:0006717
name: obsolete juvenile hormone binding
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a molecular function and not a biological process.
synonym: "juvenile hormone binding" EXACT []
is_obsolete: true
consider: GO:0005500

[Term]
id: GO:0006718
name: juvenile hormone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:go_curators, ISBN:0198547684]
synonym: "juvenile hormone anabolism" EXACT []
synonym: "juvenile hormone biosynthesis" EXACT []
synonym: "juvenile hormone formation" EXACT []
synonym: "juvenile hormone synthesis" EXACT []
is_a: GO:0006716 ! juvenile hormone metabolic process
is_a: GO:0016106 ! sesquiterpenoid biosynthetic process
is_a: GO:0042446 ! hormone biosynthetic process

[Term]
id: GO:0006719
name: juvenile hormone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:go_curators, ISBN:0198547684]
synonym: "juvenile hormone breakdown" EXACT []
synonym: "juvenile hormone catabolism" EXACT []
synonym: "juvenile hormone degradation" EXACT []
is_a: GO:0006716 ! juvenile hormone metabolic process
is_a: GO:0016107 ! sesquiterpenoid catabolic process
is_a: GO:0042447 ! hormone catabolic process

[Term]
id: GO:0006720
name: isoprenoid metabolic process
namespace: biological_process
alt_id: GO:0016096
def: "The chemical reactions and pathways involving isoprenoid compounds, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198547684]
subset: gosubset_prok
synonym: "isoprenoid metabolism" EXACT []
synonym: "polyisoprenoid metabolic process" NARROW []
synonym: "polyisoprenoid metabolism" NARROW []
synonym: "polyterpene metabolic process" NARROW []
synonym: "polyterpene metabolism" NARROW []
is_a: GO:0044255 ! cellular lipid metabolic process

[Term]
id: GO:0006721
name: terpenoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure and including derivatives with various functional groups." [ISBN:0198506732]
subset: gosubset_prok
synonym: "terpenoid metabolism" EXACT []
is_a: GO:0006720 ! isoprenoid metabolic process

[Term]
id: GO:0006722
name: triterpenoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving triterpenoid compounds, terpenoids with six isoprene units." [ISBN:0198547684]
subset: gosubset_prok
synonym: "triterpene metabolic process" NARROW []
synonym: "triterpene metabolism" NARROW []
synonym: "triterpenoid metabolism" EXACT []
is_a: GO:0006721 ! terpenoid metabolic process

[Term]
id: GO:0006723
name: cuticle hydrocarbon biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of hydrocarbons that make up the cuticle, the outer layer of some animals and plants, which acts to prevent water loss." [GOC:ai]
synonym: "cuticle hydrocarbon anabolism" EXACT []
synonym: "cuticle hydrocarbon biosynthesis" EXACT []
synonym: "cuticle hydrocarbon formation" EXACT []
synonym: "cuticle hydrocarbon synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
relationship: part_of GO:0042335 ! cuticle development

[Term]
id: GO:0006725
name: cellular aromatic compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells." [GOC:ai, ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
synonym: "aromatic compound metabolism" EXACT []
synonym: "aromatic hydrocarbon metabolic process" NARROW []
synonym: "aromatic hydrocarbon metabolism" NARROW []
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0006726
name: eye pigment biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye." [GOC:ai]
synonym: "eye pigment anabolism" EXACT []
synonym: "eye pigment biosynthesis" EXACT []
synonym: "eye pigment formation" EXACT []
synonym: "eye pigment synthesis" EXACT []
is_a: GO:0042441 ! eye pigment metabolic process
is_a: GO:0046148 ! pigment biosynthetic process

[Term]
id: GO:0006727
name: ommochrome biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye." [ISBN:0198506732]
synonym: "ommochrome anabolism" EXACT []
synonym: "ommochrome biosynthesis" EXACT []
synonym: "ommochrome formation" EXACT []
synonym: "ommochrome synthesis" EXACT []
is_a: GO:0006726 ! eye pigment biosynthetic process
is_a: GO:0008055 ! ocellus pigment biosynthetic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0046152 ! ommochrome metabolic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process

[Term]
id: GO:0006728
name: pteridine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group." [ISBN:0198506732]
subset: gosubset_prok
synonym: "pteridine anabolism" EXACT []
synonym: "pteridine biosynthesis" EXACT []
synonym: "pteridine formation" EXACT []
synonym: "pteridine synthesis" EXACT []
synonym: "pterin biosynthesis" NARROW []
synonym: "pterin biosynthetic process" NARROW []
is_a: GO:0019889 ! pteridine metabolic process
is_a: GO:0042559 ! pteridine-containing compound biosynthetic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0046148 ! pigment biosynthetic process

[Term]
id: GO:0006729
name: tetrahydrobiopterin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine." [CHEBI:15372, GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "5,6,7,8-tetrahydrobiopterin biosynthetic process" EXACT [CHEBI:15372, GOC:curators]
synonym: "tetrahydrobiopterin anabolism" EXACT []
synonym: "tetrahydrobiopterin biosynthesis" EXACT []
synonym: "tetrahydrobiopterin formation" EXACT []
synonym: "tetrahydrobiopterin synthesis" EXACT []
is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0042559 ! pteridine-containing compound biosynthetic process
is_a: GO:0046146 ! tetrahydrobiopterin metabolic process

[Term]
id: GO:0006730
name: one-carbon metabolic process
namespace: biological_process
alt_id: GO:0019753
alt_id: GO:0019754
def: "The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states." [GOC:hjd, GOC:mah, GOC:pde]
subset: goslim_pir
subset: gosubset_prok
synonym: "one carbon metabolic process" EXACT [GOC:mah]
synonym: "one carbon metabolism" EXACT [GOC:mah]
synonym: "one-carbon metabolism" EXACT [GOC:mah]
synonym: "one-carbon transfer metabolic process" EXACT [GOC:mah]
synonym: "one-carbon transfer metabolism" EXACT [GOC:mah]
xref: UM-BBD_pathwayID:C1cyc
is_a: GO:0044237 ! cellular metabolic process
is_a: GO:0044281 ! small molecule metabolic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0006731
name: obsolete coenzyme and prosthetic group metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving coenzymes and prosthetic groups." [GOC:ai]
comment: This term was made obsolete because it was replaced by more specific terms.
synonym: "coenzyme and prosthetic group metabolic process" EXACT []
is_obsolete: true
consider: GO:0006732
consider: GO:0051189

[Term]
id: GO:0006732
name: coenzyme metabolic process
namespace: biological_process
alt_id: GO:0006752
def: "The chemical reactions and pathways involving coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732]
subset: gosubset_prok
synonym: "coenzyme and prosthetic group metabolic process" BROAD []
synonym: "coenzyme and prosthetic group metabolism" BROAD []
synonym: "coenzyme metabolism" EXACT []
synonym: "group transfer coenzyme metabolic process" NARROW []
synonym: "group transfer coenzyme metabolism" NARROW []
is_a: GO:0051186 ! cofactor metabolic process

[Term]
id: GO:0006733
name: oxidoreduction coenzyme metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving coenzymes that are required, in addition to an enzyme and a substrate, for an oxidoreductase reaction to proceed." [GOC:mah]
subset: gosubset_prok
synonym: "oxidoreduction coenzyme metabolism" EXACT []
is_a: GO:0006732 ! coenzyme metabolic process

[Term]
id: GO:0006734
name: NADH metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving reduced nicotinamide adenine dinucleotide (NADH), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid." [GOC:jl, ISBN:0618254153]
subset: gosubset_prok
synonym: "NAD (reduced) metabolic process" EXACT []
synonym: "NAD (reduced) metabolism" EXACT []
synonym: "NADH metabolism" EXACT []
synonym: "reduced NAD metabolic process" EXACT []
synonym: "reduced NAD metabolism" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide metabolic process" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide metabolism" EXACT []
is_a: GO:0019674 ! NAD metabolic process

[Term]
id: GO:0006735
name: NADH regeneration
namespace: biological_process
def: "A metabolic process that generates a pool of NADH by the reduction of NAD+." [GOC:mah]
subset: gosubset_prok
synonym: "NAD (reduced) regeneration" EXACT []
synonym: "reduced NAD regeneration" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide regeneration" EXACT []
is_a: GO:0006734 ! NADH metabolic process
is_a: GO:0055114 ! oxidation-reduction process

[Term]
id: GO:0006738
name: nicotinamide riboside catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of nicotinamide riboside, the product of the formation of a glycosidic bond between ribose and nicotinamide." [ISBN:0198506732]
subset: gosubset_prok
synonym: "N-ribosylnicotinamide catabolic process" EXACT [CHEBI:15927]
synonym: "nicotinamide riboside breakdown" EXACT []
synonym: "nicotinamide riboside catabolism" EXACT []
synonym: "nicotinamide riboside degradation" EXACT []
is_a: GO:0046495 ! nicotinamide riboside metabolic process
is_a: GO:0070638 ! pyridine nucleoside catabolic process

[Term]
id: GO:0006739
name: NADP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; metabolism may be of either the oxidized form, NADP, or the reduced form, NADPH." [GOC:mah]
subset: gosubset_prok
synonym: "NAD phosphorylation and dephosphorylation" RELATED []
synonym: "NADP (oxidized) metabolic process" EXACT []
synonym: "NADP (oxidized) metabolism" EXACT []
synonym: "NADP (reduced) metabolic process" EXACT []
synonym: "NADP (reduced) metabolism" EXACT []
synonym: "NADP metabolism" EXACT []
synonym: "NADPH metabolic process" EXACT []
synonym: "NADPH metabolism" EXACT []
synonym: "nicotinamide adenine dinucleotide phosphate metabolic process" EXACT []
synonym: "nicotinamide adenine dinucleotide phosphate metabolism" EXACT []
synonym: "oxidized NADP metabolic process" EXACT []
synonym: "oxidized NADP metabolism" EXACT []
synonym: "oxidized nicotinamide adenine dinucleotide phosphate metabolic process" EXACT []
synonym: "oxidized nicotinamide adenine dinucleotide phosphate metabolism" EXACT []
synonym: "reduced NADP metabolic process" EXACT []
synonym: "reduced NADP metabolism" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide phosphate metabolic process" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide phosphate metabolism" EXACT []
is_a: GO:0046496 ! nicotinamide nucleotide metabolic process

[Term]
id: GO:0006740
name: NADPH regeneration
namespace: biological_process
def: "A metabolic process that generates a pool of NADPH by the reduction of NADP+." [GOC:mah]
subset: gosubset_prok
synonym: "NADP (reduced) regeneration" EXACT []
synonym: "reduced NADP regeneration" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide phosphate regeneration" EXACT []
xref: Reactome:REACT_103795 "NADPH regeneration, Mycobacterium tuberculosis"
xref: Reactome:REACT_104046 "NADPH regeneration, Canis familiaris"
xref: Reactome:REACT_107775 "NADPH regeneration, Taeniopygia guttata"
xref: Reactome:REACT_107860 "NADPH regeneration, Mus musculus"
xref: Reactome:REACT_110205 "NADPH regeneration, Rattus norvegicus"
xref: Reactome:REACT_113557 "NADPH regeneration, Arabidopsis thaliana"
xref: Reactome:REACT_114218 "NADPH regeneration, Plasmodium falciparum"
xref: Reactome:REACT_115247 "NADPH regeneration, Oryza sativa"
xref: Reactome:REACT_16904 "NADPH regeneration, Homo sapiens"
xref: Reactome:REACT_68947 "NADPH regeneration, Caenorhabditis elegans"
xref: Reactome:REACT_78166 "NADPH regeneration, Saccharomyces cerevisiae"
xref: Reactome:REACT_79060 "NADPH regeneration, Schizosaccharomyces pombe"
xref: Reactome:REACT_80103 "NADPH regeneration, Drosophila melanogaster"
xref: Reactome:REACT_84899 "NADPH regeneration, Danio rerio"
xref: Reactome:REACT_87346 "NADPH regeneration, Gallus gallus"
xref: Reactome:REACT_90733 "NADPH regeneration, Xenopus tropicalis"
xref: Reactome:REACT_91704 "NADPH regeneration, Dictyostelium discoideum"
xref: Reactome:REACT_96662 "NADPH regeneration, Bos taurus"
is_a: GO:0006739 ! NADP metabolic process
is_a: GO:0055114 ! oxidation-reduction process

[Term]
id: GO:0006741
name: NADP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; biosynthesis may be of either the oxidized form, NADP, or the reduced form, NADPH." [GOC:mah]
subset: gosubset_prok
synonym: "NADP (oxidized) biosynthesis" EXACT []
synonym: "NADP (oxidized) biosynthetic process" EXACT []
synonym: "NADP (reduced) biosynthesis" EXACT []
synonym: "NADP (reduced) biosynthetic process" EXACT []
synonym: "NADP anabolism" EXACT []
synonym: "NADP biosynthesis" EXACT []
synonym: "NADP formation" EXACT []
synonym: "NADP synthesis" EXACT []
synonym: "NADPH biosynthesis" EXACT []
synonym: "NADPH biosynthetic process" EXACT []
synonym: "nicotinamide adenine dinucleotide phosphate biosynthesis" EXACT []
synonym: "nicotinamide adenine dinucleotide phosphate biosynthetic process" EXACT []
synonym: "oxidized NADP biosynthesis" EXACT []
synonym: "oxidized NADP biosynthetic process" EXACT []
synonym: "oxidized nicotinamide adenine dinucleotide phosphate biosynthesis" EXACT []
synonym: "oxidized nicotinamide adenine dinucleotide phosphate biosynthetic process" EXACT []
synonym: "reduced NADP biosynthesis" EXACT []
synonym: "reduced NADP biosynthetic process" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide phosphate biosynthesis" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide phosphate biosynthetic process" EXACT []
is_a: GO:0006739 ! NADP metabolic process
is_a: GO:0019359 ! nicotinamide nucleotide biosynthetic process

[Term]
id: GO:0006742
name: NADP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; catabolism may be of either the oxidized form, NADP, or the reduced form, NADPH." [GOC:mah]
subset: gosubset_prok
synonym: "NADP (oxidized) catabolic process" EXACT []
synonym: "NADP (oxidized) catabolism" EXACT []
synonym: "NADP (reduced) catabolic process" EXACT []
synonym: "NADP (reduced) catabolism" EXACT []
synonym: "NADP breakdown" EXACT []
synonym: "NADP catabolism" EXACT []
synonym: "NADP degradation" EXACT []
synonym: "NADPH catabolic process" EXACT []
synonym: "NADPH catabolism" EXACT []
synonym: "nicotinamide adenine dinucleotide phosphate catabolic process" EXACT []
synonym: "nicotinamide adenine dinucleotide phosphate catabolism" EXACT []
synonym: "oxidized NADP catabolic process" EXACT []
synonym: "oxidized NADP catabolism" EXACT []
synonym: "oxidized nicotinamide adenine dinucleotide phosphate catabolic process" EXACT []
synonym: "oxidized nicotinamide adenine dinucleotide phosphate catabolism" EXACT []
synonym: "reduced NADP catabolic process" EXACT []
synonym: "reduced NADP catabolism" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide phosphate catabolic process" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide phosphate catabolism" EXACT []
is_a: GO:0006739 ! NADP metabolic process
is_a: GO:0019364 ! pyridine nucleotide catabolic process

[Term]
id: GO:0006743
name: ubiquinone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah]
subset: gosubset_prok
synonym: "coenzyme Q metabolic process" EXACT []
synonym: "coenzyme Q metabolism" EXACT []
synonym: "ubiquinone metabolism" EXACT []
is_a: GO:0006733 ! oxidoreduction coenzyme metabolic process
is_a: GO:1901661 ! quinone metabolic process

[Term]
id: GO:0006744
name: ubiquinone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah]
subset: gosubset_prok
synonym: "coenzyme Q biosynthesis" EXACT []
synonym: "coenzyme Q biosynthetic process" EXACT []
synonym: "coenzyme Q10 biosynthesis" NARROW []
synonym: "coenzyme Q10 biosynthetic process" NARROW []
synonym: "coenzyme Q6 biosynthesis" NARROW []
synonym: "coenzyme Q6 biosynthetic process" NARROW []
synonym: "coenzyme Q8 biosynthesis" NARROW []
synonym: "coenzyme Q8 biosynthetic process" NARROW []
synonym: "coenzyme Q9 biosynthesis" NARROW []
synonym: "coenzyme Q9 biosynthetic process" NARROW []
synonym: "ubiquinone anabolism" EXACT []
synonym: "ubiquinone biosynthesis" EXACT []
synonym: "ubiquinone formation" EXACT []
synonym: "ubiquinone synthesis" EXACT []
xref: MetaCyc:UBISYN-PWY
is_a: GO:0006743 ! ubiquinone metabolic process
is_a: GO:1901663 ! quinone biosynthetic process

[Term]
id: GO:0006746
name: FADH2 metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the reduced form of flavin adenine dinucleotide." [CHEBI:17877, GOC:ai]
subset: gosubset_prok
synonym: "FADH2 metabolism" EXACT []
synonym: "reduced flavin adenine dinucleotide metabolic process" EXACT [GOC:mah]
is_a: GO:0006733 ! oxidoreduction coenzyme metabolic process
is_a: GO:0072387 ! flavin adenine dinucleotide metabolic process

[Term]
id: GO:0006747
name: FAD biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of FAD, the oxidized form of flavin-adenine dinucleotide." [CHEBI:16238, GOC:ai, ISBN:0198506732]
subset: gosubset_prok
synonym: "FAD anabolism" EXACT []
synonym: "FAD biosynthesis" EXACT []
synonym: "FAD formation" EXACT []
synonym: "FAD synthesis" EXACT []
synonym: "oxidized flavin adenine dinucleotide biosynthesis" EXACT [GOC:curators]
synonym: "oxidized flavin adenine dinucleotide biosynthetic process" EXACT [GOC:curators]
synonym: "oxidized flavin-adenine dinucleotide biosynthesis" EXACT [GOC:curators]
synonym: "oxidized flavin-adenine dinucleotide biosynthetic process" EXACT [GOC:curators]
is_a: GO:0046443 ! FAD metabolic process
is_a: GO:0072388 ! flavin adenine dinucleotide biosynthetic process

[Term]
id: GO:0006748
name: lipoamide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lipoamide, the functional form of lipoic acid in which the carboxyl group is attached to protein by an amide linkage to a lysine amino group." [CHEBI:17460, GOC:go_curators]
subset: gosubset_prok
synonym: "lipoamide metabolism" EXACT []
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0043603 ! cellular amide metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process

[Term]
id: GO:0006749
name: glutathione metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [CHEBI:16856, ISBN:0198506732]
subset: gosubset_prok
synonym: "glutathione metabolism" EXACT []
synonym: "oxidized glutathione reduction" NARROW []
is_a: GO:0006518 ! peptide metabolic process
is_a: GO:0006575 ! cellular modified amino acid metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process

[Term]
id: GO:0006750
name: glutathione biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins." [CHEBI:16856, GOC:ai, GOC:al, GOC:pde, ISBN:0198506732]
subset: gosubset_prok
synonym: "glutathione anabolism" EXACT []
synonym: "glutathione biosynthesis" EXACT []
synonym: "glutathione formation" EXACT []
synonym: "glutathione synthesis" EXACT []
xref: MetaCyc:GLUTATHIONESYN-PWY
xref: Reactome:REACT_103397 "Glutathione synthesis and recycling, Rattus norvegicus"
xref: Reactome:REACT_105261 "Glutathione synthesis and recycling, Schizosaccharomyces pombe"
xref: Reactome:REACT_110421 "Glutathione synthesis and recycling, Canis familiaris"
xref: Reactome:REACT_110743 "Glutathione synthesis and recycling, Mus musculus"
xref: Reactome:REACT_32911 "Glutathione synthesis and recycling, Arabidopsis thaliana"
xref: Reactome:REACT_33459 "Glutathione synthesis and recycling, Sus scrofa"
xref: Reactome:REACT_6960 "Glutathione synthesis and recycling, Homo sapiens"
xref: Reactome:REACT_81322 "Glutathione synthesis and recycling, Danio rerio"
xref: Reactome:REACT_82189 "Glutathione synthesis and recycling, Xenopus tropicalis"
xref: Reactome:REACT_84374 "Glutathione synthesis and recycling, Caenorhabditis elegans"
xref: Reactome:REACT_85658 "Glutathione synthesis and recycling, Saccharomyces cerevisiae"
xref: Reactome:REACT_88522 "Glutathione synthesis and recycling, Bos taurus"
xref: Reactome:REACT_90769 "Glutathione synthesis and recycling, Oryza sativa"
xref: Reactome:REACT_92740 "Glutathione synthesis and recycling, Gallus gallus"
xref: Reactome:REACT_94932 "Glutathione synthesis and recycling, Dictyostelium discoideum"
xref: Reactome:REACT_96555 "Glutathione synthesis and recycling, Taeniopygia guttata"
xref: Reactome:REACT_97813 "Glutathione synthesis and recycling, Plasmodium falciparum"
xref: Reactome:REACT_98722 "Glutathione synthesis and recycling, Drosophila melanogaster"
is_a: GO:0006749 ! glutathione metabolic process
is_a: GO:0019184 ! nonribosomal peptide biosynthetic process
is_a: GO:0042398 ! cellular modified amino acid biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process

[Term]
id: GO:0006751
name: glutathione catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins." [CHEBI:16856, GOC:ai, ISBN:0198506732]
subset: gosubset_prok
synonym: "glutathione breakdown" EXACT []
synonym: "glutathione catabolism" EXACT []
synonym: "glutathione degradation" EXACT []
is_a: GO:0006749 ! glutathione metabolic process
is_a: GO:0042219 ! cellular modified amino acid catabolic process
is_a: GO:0043171 ! peptide catabolic process
is_a: GO:0044273 ! sulfur compound catabolic process

[Term]
id: GO:0006753
name: nucleoside phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any phosphorylated nucleoside." [GOC:mah]
subset: gosubset_prok
synonym: "nucleoside phosphate metabolism" EXACT []
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:0055086 ! nucleobase-containing small molecule metabolic process

[Term]
id: GO:0006754
name: ATP biosynthetic process
namespace: biological_process
alt_id: GO:0006758
alt_id: GO:0006759
def: "The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "ATP anabolism" EXACT []
synonym: "ATP biosynthesis" EXACT []
synonym: "ATP formation" EXACT []
synonym: "ATP regeneration" NARROW []
synonym: "ATP synthesis" EXACT []
xref: Reactome:REACT_102219 "ADP and Pi bind to ATPase, Gallus gallus"
xref: Reactome:REACT_104315 "ATP is synthesized from ADP and Pi by ATPase, Bos taurus"
xref: Reactome:REACT_105384 "ATP is synthesized from ADP and Pi by ATPase, Rattus norvegicus"
xref: Reactome:REACT_106830 "ATP is synthesized from ADP and Pi by ATPase, Canis familiaris"
xref: Reactome:REACT_109466 "ADP and Pi bind to ATPase, Mus musculus"
xref: Reactome:REACT_190 "ATP is synthesized from ADP and Pi by ATPase, Homo sapiens"
xref: Reactome:REACT_28537 "ADP and Pi bind to ATPase, Sus scrofa"
xref: Reactome:REACT_31626 "ADP and Pi bind to ATPase, Rattus norvegicus"
xref: Reactome:REACT_33014 "ATP is synthesized from ADP and Pi by ATPase, Danio rerio"
xref: Reactome:REACT_78557 "ADP and Pi bind to ATPase, Bos taurus"
xref: Reactome:REACT_86305 "ATP is synthesized from ADP and Pi by ATPase, Gallus gallus"
xref: Reactome:REACT_88682 "ADP and Pi bind to ATPase, Danio rerio"
xref: Reactome:REACT_90150 "ADP and Pi bind to ATPase, Canis familiaris"
xref: Reactome:REACT_92655 "ATP is synthesized from ADP and Pi by ATPase, Mus musculus"
xref: Reactome:REACT_96844 "ATP is synthesized from ADP and Pi by ATPase, Sus scrofa"
xref: Reactome:REACT_991 "ADP and Pi bind to ATPase, Homo sapiens"
is_a: GO:0009152 ! purine ribonucleotide biosynthetic process
is_a: GO:0009168 ! purine ribonucleoside monophosphate biosynthetic process
is_a: GO:0009206 ! purine ribonucleoside triphosphate biosynthetic process
is_a: GO:0046034 ! ATP metabolic process
is_a: GO:0046129 ! purine ribonucleoside biosynthetic process

[Term]
id: GO:0006755
name: obsolete carbamoyl phosphate-ADP transphosphorylation
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because, according to PUMA2, this "pathway" is a single reaction, corresponding to 'carbamate kinase activity ; GO:0008804' (EC:2.7.2.2).
synonym: "carbamoyl phosphate-ADP transphosphorylation" EXACT []
is_obsolete: true

[Term]
id: GO:0006756
name: AMP phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group into AMP, adenosine monophosphate, to produce ADP. Addition of two phosphate groups produces ATP." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006754 ! ATP biosynthetic process
is_a: GO:0046033 ! AMP metabolic process
is_a: GO:0046940 ! nucleoside monophosphate phosphorylation

[Term]
id: GO:0006757
name: ATP generation from ADP
namespace: biological_process
def: "The process of introducing a phosphate group into ADP, adenosine diphosphate, to produce ATP." [GOC:ai]
subset: gosubset_prok
synonym: "ADP phosphorylation" EXACT [GOC:dph]
is_a: GO:0006091 ! generation of precursor metabolites and energy
is_a: GO:0006165 ! nucleoside diphosphate phosphorylation
is_a: GO:0046031 ! ADP metabolic process
is_a: GO:0046034 ! ATP metabolic process

[Term]
id: GO:0006760
name: folic acid-containing compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a folic acid-containing compound, i.e. any of a group of heterocyclic compounds based on the pteroic acid skeleton conjugated with one or more L-glutamic acid or L-glutamate units." [CHEBI:37445, GOC:ai, GOC:mah]
subset: gosubset_prok
synonym: "folate and derivative metabolic process" EXACT []
synonym: "folate and derivative metabolism" EXACT []
synonym: "folate-containing compound metabolic process" EXACT [GOC:curators]
synonym: "folate-containing compound metabolism" EXACT [GOC:curators]
synonym: "folic acid and derivative metabolic process" EXACT [GOC:curators]
synonym: "folic acid and derivative metabolism" EXACT [GOC:curators]
synonym: "folic acid-containing compound metabolism" EXACT [GOC:curators]
synonym: "vitamin B9 and derivative metabolic process" EXACT []
synonym: "vitamin B9 and derivative metabolism" EXACT []
synonym: "vitamin M and derivative metabolic process" EXACT []
synonym: "vitamin M and derivative metabolism" EXACT []
is_a: GO:0006575 ! cellular modified amino acid metabolic process
is_a: GO:0006732 ! coenzyme metabolic process
is_a: GO:0042558 ! pteridine-containing compound metabolic process
is_a: GO:0043603 ! cellular amide metabolic process
is_a: GO:1901605 ! alpha-amino acid metabolic process

[Term]
id: GO:0006761
name: dihydrofolate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dihydrofolate, the dihydroxylated derivative of folate." [GOC:ai]
subset: gosubset_prok
synonym: "7,8-dihydrofolate biosynthesis" EXACT []
synonym: "7,8-dihydrofolate biosynthetic process" EXACT []
synonym: "dihydrofolate anabolism" EXACT []
synonym: "dihydrofolate biosynthesis" EXACT []
synonym: "dihydrofolate formation" EXACT []
synonym: "dihydrofolate synthesis" EXACT []
is_a: GO:0009396 ! folic acid-containing compound biosynthetic process
is_a: GO:0043650 ! dicarboxylic acid biosynthetic process
is_a: GO:0046452 ! dihydrofolate metabolic process

[Term]
id: GO:0006762
name: obsolete dihydrofolate reduction
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function rather than a biological process.
synonym: "dihydrofolate reduction" EXACT []
is_obsolete: true
consider: GO:0004146
consider: GO:0046452

[Term]
id: GO:0006766
name: vitamin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems." [GOC:ai]
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_pir
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "vitamin metabolism" EXACT []
xref: Reactome:REACT_101808 "Metabolism of vitamins and cofactors, Bos taurus"
xref: Reactome:REACT_101968 "Metabolism of vitamins and cofactors, Saccharomyces cerevisiae"
xref: Reactome:REACT_102472 "Vitamins, Xenopus tropicalis"
xref: Reactome:REACT_103646 "Metabolism of vitamins and cofactors, Staphylococcus aureus N315"
xref: Reactome:REACT_104403 "Vitamins, Bos taurus"
xref: Reactome:REACT_105907 "Metabolism of vitamins and cofactors, Danio rerio"
xref: Reactome:REACT_106152 "Metabolism of vitamins and cofactors, Xenopus tropicalis"
xref: Reactome:REACT_108558 "Metabolism of vitamins and cofactors, Rattus norvegicus"
xref: Reactome:REACT_110948 "Metabolism of vitamins and cofactors, Sus scrofa"
xref: Reactome:REACT_11193 "Metabolism of vitamins and cofactors, Homo sapiens"
xref: Reactome:REACT_13450 "Vitamins, Homo sapiens"
xref: Reactome:REACT_30091 "Metabolism of vitamins and cofactors, Oryza sativa"
xref: Reactome:REACT_31562 "Vitamins, Sus scrofa"
xref: Reactome:REACT_33241 "Vitamins, Oryza sativa"
xref: Reactome:REACT_33738 "Metabolism of vitamins and cofactors, Mycobacterium tuberculosis"
xref: Reactome:REACT_34161 "Metabolism of vitamins and cofactors, Mus musculus"
xref: Reactome:REACT_34372 "Vitamins, Taeniopygia guttata"
xref: Reactome:REACT_36524 "Vitamins, Gallus gallus"
xref: Reactome:REACT_78899 "Metabolism of vitamins and cofactors, Caenorhabditis elegans"
xref: Reactome:REACT_79004 "Vitamins, Danio rerio"
xref: Reactome:REACT_80415 "Vitamins, Rattus norvegicus"
xref: Reactome:REACT_81509 "Metabolism of vitamins and cofactors, Gallus gallus"
xref: Reactome:REACT_82129 "Metabolism of vitamins and cofactors, Taeniopygia guttata"
xref: Reactome:REACT_82903 "Vitamins, Canis familiaris"
xref: Reactome:REACT_83508 "Metabolism of vitamins and cofactors, Arabidopsis thaliana"
xref: Reactome:REACT_84128 "Vitamins, Drosophila melanogaster"
xref: Reactome:REACT_87513 "Metabolism of vitamins and cofactors, Schizosaccharomyces pombe"
xref: Reactome:REACT_88847 "Vitamins, Mus musculus"
xref: Reactome:REACT_88850 "Metabolism of vitamins and cofactors, Dictyostelium discoideum"
xref: Reactome:REACT_90099 "Vitamins, Arabidopsis thaliana"
xref: Reactome:REACT_96278 "Metabolism of vitamins and cofactors, Plasmodium falciparum"
xref: Reactome:REACT_96904 "Metabolism of vitamins and cofactors, Drosophila melanogaster"
xref: Reactome:REACT_97734 "Metabolism of vitamins and cofactors, Escherichia coli"
xref: Reactome:REACT_97893 "Metabolism of vitamins and cofactors, Canis familiaris"
is_a: GO:0044281 ! small molecule metabolic process

[Term]
id: GO:0006767
name: water-soluble vitamin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any of a diverse group of vitamins that are soluble in water." [GOC:jl]
subset: gosubset_prok
synonym: "water-soluble vitamin metabolism" EXACT []
xref: Reactome:REACT_102551 "Metabolism of water-soluble vitamins and cofactors, Saccharomyces cerevisiae"
xref: Reactome:REACT_104143 "Metabolism of water-soluble vitamins and cofactors, Plasmodium falciparum"
xref: Reactome:REACT_105277 "Metabolism of water-soluble vitamins and cofactors, Canis familiaris"
xref: Reactome:REACT_106003 "Metabolism of water-soluble vitamins and cofactors, Mycobacterium tuberculosis"
xref: Reactome:REACT_107096 "Metabolism of water-soluble vitamins and cofactors, Oryza sativa"
xref: Reactome:REACT_107256 "Metabolism of water-soluble vitamins and cofactors, Gallus gallus"
xref: Reactome:REACT_109668 "Metabolism of water-soluble vitamins and cofactors, Sus scrofa"
xref: Reactome:REACT_11238 "Metabolism of water-soluble vitamins and cofactors, Homo sapiens"
xref: Reactome:REACT_28813 "Metabolism of water-soluble vitamins and cofactors, Caenorhabditis elegans"
xref: Reactome:REACT_30368 "Metabolism of water-soluble vitamins and cofactors, Xenopus tropicalis"
xref: Reactome:REACT_79418 "Metabolism of water-soluble vitamins and cofactors, Dictyostelium discoideum"
xref: Reactome:REACT_79988 "Metabolism of water-soluble vitamins and cofactors, Mus musculus"
xref: Reactome:REACT_82631 "Metabolism of water-soluble vitamins and cofactors, Taeniopygia guttata"
xref: Reactome:REACT_85326 "Metabolism of water-soluble vitamins and cofactors, Bos taurus"
xref: Reactome:REACT_86005 "Metabolism of water-soluble vitamins and cofactors, Arabidopsis thaliana"
xref: Reactome:REACT_90308 "Metabolism of water-soluble vitamins and cofactors, Schizosaccharomyces pombe"
xref: Reactome:REACT_90860 "Metabolism of water-soluble vitamins and cofactors, Escherichia coli"
xref: Reactome:REACT_91435 "Metabolism of water-soluble vitamins and cofactors, Danio rerio"
xref: Reactome:REACT_92473 "Metabolism of water-soluble vitamins and cofactors, Rattus norvegicus"
xref: Reactome:REACT_98755 "Metabolism of water-soluble vitamins and cofactors, Staphylococcus aureus N315"
xref: Reactome:REACT_99870 "Metabolism of water-soluble vitamins and cofactors, Drosophila melanogaster"
is_a: GO:0006766 ! vitamin metabolic process

[Term]
id: GO:0006768
name: biotin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions." [ISBN:0198506732]
subset: gosubset_prok
synonym: "biotin metabolism" EXACT []
synonym: "vitamin B7 metabolic process" EXACT []
synonym: "vitamin B7 metabolism" EXACT []
synonym: "vitamin H metabolic process" EXACT []
synonym: "vitamin H metabolism" EXACT []
xref: Reactome:REACT_101854 "Biotin metabolism, Canis familiaris"
xref: Reactome:REACT_102636 "Biotin metabolism, Staphylococcus aureus N315"
xref: Reactome:REACT_106307 "Biotin metabolism, Mus musculus"
xref: Reactome:REACT_110021 "Biotin metabolism, Taeniopygia guttata"
xref: Reactome:REACT_11153 "Biotin metabolism, Homo sapiens"
xref: Reactome:REACT_31380 "Biotin metabolism, Xenopus tropicalis"
xref: Reactome:REACT_34499 "Biotin metabolism, Rattus norvegicus"
xref: Reactome:REACT_81229 "Biotin metabolism, Danio rerio"
xref: Reactome:REACT_88569 "Biotin metabolism, Bos taurus"
xref: Reactome:REACT_88585 "Biotin metabolism, Sus scrofa"
xref: Wikipedia:Biotin
is_a: GO:0006767 ! water-soluble vitamin metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0043603 ! cellular amide metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:0051186 ! cofactor metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process

[Term]
id: GO:0006769
name: nicotinamide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nicotinamide, pyridine-3-carboxamide, the amide of nicotinic acid. It is a member of the B complex of vitamins and occurs widely in living organisms." [ISBN:0198506732]
subset: gosubset_prok
synonym: "niacin metabolic process" RELATED []
synonym: "niacin metabolism" RELATED []
synonym: "nicotinamide metabolism" EXACT []
synonym: "vitamin B3 metabolic process" BROAD []
synonym: "vitamin B3 metabolism" BROAD []
xref: MetaCyc:PWY-5083
xref: Reactome:REACT_100709 "Nicotinamide salvaging, Arabidopsis thaliana"
xref: Reactome:REACT_101360 "Nicotinamide salvaging, Taeniopygia guttata"
xref: Reactome:REACT_101907 "Nicotinamide salvaging, Mycobacterium tuberculosis"
xref: Reactome:REACT_101936 "Nicotinamide salvaging, Oryza sativa"
xref: Reactome:REACT_103464 "Nicotinamide salvaging, Bos taurus"
xref: Reactome:REACT_103745 "Nicotinamide salvaging, Sus scrofa"
xref: Reactome:REACT_104665 "Nicotinamide salvaging, Plasmodium falciparum"
xref: Reactome:REACT_107651 "Nicotinamide salvaging, Gallus gallus"
xref: Reactome:REACT_108395 "Nicotinamide salvaging, Drosophila melanogaster"
xref: Reactome:REACT_108628 "Nicotinamide salvaging, Caenorhabditis elegans"
xref: Reactome:REACT_110344 "Nicotinamide salvaging, Danio rerio"
xref: Reactome:REACT_11213 "Nicotinamide salvaging, Homo sapiens"
xref: Reactome:REACT_29179 "Nicotinamide salvaging, Mus musculus"
xref: Reactome:REACT_29962 "Nicotinamide salvaging, Escherichia coli"
xref: Reactome:REACT_83244 "Nicotinamide salvaging, Dictyostelium discoideum"
xref: Reactome:REACT_85336 "Nicotinamide salvaging, Xenopus tropicalis"
xref: Reactome:REACT_88502 "Nicotinamide salvaging, Rattus norvegicus"
xref: Reactome:REACT_89953 "Nicotinamide salvaging, Staphylococcus aureus N315"
xref: Reactome:REACT_98288 "Nicotinamide salvaging, Canis familiaris"
is_a: GO:0006767 ! water-soluble vitamin metabolic process
is_a: GO:0009820 ! alkaloid metabolic process
is_a: GO:0043603 ! cellular amide metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0072524 ! pyridine-containing compound metabolic process

[Term]
id: GO:0006771
name: riboflavin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD)." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html]
subset: gosubset_prok
synonym: "riboflavin metabolism" EXACT []
synonym: "vitamin B2 metabolic process" EXACT []
synonym: "vitamin B2 metabolism" EXACT []
synonym: "vitamin G metabolic process" EXACT []
synonym: "vitamin G metabolism" EXACT []
xref: Reactome:REACT_101380 "Vitamin B2 (riboflavin) metabolism, Dictyostelium discoideum"
xref: Reactome:REACT_102574 "Vitamin B2 (riboflavin) metabolism, Caenorhabditis elegans"
xref: Reactome:REACT_108993 "Vitamin B2 (riboflavin) metabolism, Mus musculus"
xref: Reactome:REACT_11070 "Vitamin B2 (riboflavin) metabolism, Homo sapiens"
xref: Reactome:REACT_31502 "Vitamin B2 (riboflavin) metabolism, Plasmodium falciparum"
xref: Reactome:REACT_32926 "Vitamin B2 (riboflavin) metabolism, Sus scrofa"
xref: Reactome:REACT_33829 "Vitamin B2 (riboflavin) metabolism, Oryza sativa"
xref: Reactome:REACT_34301 "Vitamin B2 (riboflavin) metabolism, Danio rerio"
xref: Reactome:REACT_79131 "Vitamin B2 (riboflavin) metabolism, Saccharomyces cerevisiae"
xref: Reactome:REACT_84309 "Vitamin B2 (riboflavin) metabolism, Drosophila melanogaster"
xref: Reactome:REACT_85324 "Vitamin B2 (riboflavin) metabolism, Rattus norvegicus"
xref: Reactome:REACT_86671 "Vitamin B2 (riboflavin) metabolism, Gallus gallus"
xref: Reactome:REACT_86951 "Vitamin B2 (riboflavin) metabolism, Schizosaccharomyces pombe"
xref: Reactome:REACT_90589 "Vitamin B2 (riboflavin) metabolism, Xenopus tropicalis"
xref: Reactome:REACT_92695 "Vitamin B2 (riboflavin) metabolism, Arabidopsis thaliana"
xref: Reactome:REACT_94893 "Vitamin B2 (riboflavin) metabolism, Bos taurus"
xref: Reactome:REACT_95901 "Vitamin B2 (riboflavin) metabolism, Taeniopygia guttata"
xref: Reactome:REACT_97198 "Vitamin B2 (riboflavin) metabolism, Canis familiaris"
xref: Wikipedia:Riboflavin
is_a: GO:0006767 ! water-soluble vitamin metabolic process
is_a: GO:0042726 ! flavin-containing compound metabolic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0006772
name: thiamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver." [CHEBI:18385, GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "thiamin metabolic process" EXACT [GOC:curators]
synonym: "thiamin metabolism" EXACT []
synonym: "thiamine metabolism" EXACT []
synonym: "vitamin B1 metabolic process" EXACT []
synonym: "vitamin B1 metabolism" EXACT []
xref: Wikipedia:Thiamine
is_a: GO:0042723 ! thiamine-containing compound metabolic process

[Term]
id: GO:0006774
name: obsolete vitamin B12 reduction
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function rather than a biological process.
synonym: "vitamin B12 reduction" EXACT []
is_obsolete: true
consider: GO:0009235
consider: GO:0050453

[Term]
id: GO:0006775
name: fat-soluble vitamin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "fat-soluble vitamin metabolism" EXACT []
is_a: GO:0006766 ! vitamin metabolic process

[Term]
id: GO:0006776
name: vitamin A metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid, all of which are derivatives of beta-carotene." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k]
subset: gosubset_prok
synonym: "vitamin A metabolism" EXACT []
is_a: GO:0001523 ! retinoid metabolic process
is_a: GO:0006775 ! fat-soluble vitamin metabolic process

[Term]
id: GO:0006777
name: Mo-molybdopterin cofactor biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands." [http://www.sunysb.edu/biochem/BIOCHEM/facultypages/schindelin/, ISSN:09498257, PMID:22370186, PMID:23201473]
subset: gosubset_prok
synonym: "Mo-molybdopterin cofactor anabolism" EXACT []
synonym: "Mo-molybdopterin cofactor biosynthesis" EXACT []
synonym: "Mo-molybdopterin cofactor formation" EXACT []
synonym: "Mo-molybdopterin cofactor synthesis" EXACT []
synonym: "Moco biosynthesis" EXACT []
synonym: "Moco biosynthetic process" EXACT []
synonym: "molybdenum cofactor biosynthetic process" RELATED []
xref: MetaCyc:PWY-6823
is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0019538 ! protein metabolic process
is_a: GO:0019720 ! Mo-molybdopterin cofactor metabolic process
is_a: GO:0032324 ! molybdopterin cofactor biosynthetic process
relationship: has_part GO:0018315 ! molybdenum incorporation into molybdenum-molybdopterin complex

[Term]
id: GO:0006778
name: porphyrin-containing compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any member of a large group of derivatives or analogs of porphyrin. Porphyrins consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "porphyrin metabolic process" RELATED []
synonym: "porphyrin metabolism" RELATED []
xref: Reactome:REACT_100361 "Metabolism of porphyrins, Taeniopygia guttata"
xref: Reactome:REACT_103508 "Metabolism of porphyrins, Arabidopsis thaliana"
xref: Reactome:REACT_104024 "Metabolism of porphyrins, Plasmodium falciparum"
xref: Reactome:REACT_105251 "Metabolism of porphyrins, Rattus norvegicus"
xref: Reactome:REACT_106196 "Metabolism of porphyrins, Gallus gallus"
xref: Reactome:REACT_108935 "Metabolism of porphyrins, Xenopus tropicalis"
xref: Reactome:REACT_112552 "Metabolism of porphyrins, Caenorhabditis elegans"
xref: Reactome:REACT_30128 "Metabolism of porphyrins, Mycobacterium tuberculosis"
xref: Reactome:REACT_31598 "Metabolism of porphyrins, Drosophila melanogaster"
xref: Reactome:REACT_78336 "Metabolism of porphyrins, Mus musculus"
xref: Reactome:REACT_79998 "Metabolism of porphyrins, Escherichia coli"
xref: Reactome:REACT_80114 "Metabolism of porphyrins, Oryza sativa"
xref: Reactome:REACT_80583 "Metabolism of porphyrins, Schizosaccharomyces pombe"
xref: Reactome:REACT_81026 "Metabolism of porphyrins, Canis familiaris"
xref: Reactome:REACT_82672 "Metabolism of porphyrins, Bos taurus"
xref: Reactome:REACT_83643 "Metabolism of porphyrins, Saccharomyces cerevisiae"
xref: Reactome:REACT_87067 "Metabolism of porphyrins, Sus scrofa"
xref: Reactome:REACT_89963 "Metabolism of porphyrins, Dictyostelium discoideum"
xref: Reactome:REACT_91680 "Metabolism of porphyrins, Staphylococcus aureus N315"
xref: Reactome:REACT_9431 "Metabolism of porphyrins, Homo sapiens"
xref: Reactome:REACT_97983 "Metabolism of porphyrins, Danio rerio"
xref: Wikipedia:Porphyrin
is_a: GO:0033013 ! tetrapyrrole metabolic process
is_a: GO:0051186 ! cofactor metabolic process

[Term]
id: GO:0006779
name: porphyrin-containing compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "porphyrin anabolism" RELATED []
synonym: "porphyrin biosynthesis" RELATED []
synonym: "porphyrin biosynthetic process" RELATED []
synonym: "porphyrin formation" RELATED []
synonym: "porphyrin synthesis" RELATED []
is_a: GO:0006778 ! porphyrin-containing compound metabolic process
is_a: GO:0033014 ! tetrapyrrole biosynthetic process
is_a: GO:0051188 ! cofactor biosynthetic process

[Term]
id: GO:0006780
name: uroporphyrinogen III biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of uroporphyrinogen III." [GOC:ai]
subset: gosubset_prok
synonym: "uroporphyrinogen III anabolism" EXACT []
synonym: "uroporphyrinogen III biosynthesis" EXACT []
synonym: "uroporphyrinogen III formation" EXACT []
synonym: "uroporphyrinogen III synthesis" EXACT []
is_a: GO:0006779 ! porphyrin-containing compound biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
is_a: GO:0046502 ! uroporphyrinogen III metabolic process

[Term]
id: GO:0006781
name: succinyl-CoA pathway
namespace: biological_process
def: "The chemical reactions that utilize succinyl-CoA in the synthesis of protoporphyrin IX." [GOC:isa_complete, ISBN:0879010479]
subset: gosubset_prok
synonym: "biosynthesis of protoporphyrin IX via succinyl CoA" EXACT []
synonym: "biosynthesis of protoporphyrin IX via succinyl-CoA" EXACT []
synonym: "biosynthetic process of protoporphyrin IX via succinyl CoA" EXACT []
synonym: "biosynthetic process of protoporphyrin IX via succinyl-CoA" EXACT []
synonym: "succinyl CoA pathway" EXACT []
is_a: GO:0006104 ! succinyl-CoA metabolic process
is_a: GO:0006779 ! porphyrin-containing compound biosynthetic process
relationship: part_of GO:0006780 ! uroporphyrinogen III biosynthetic process

[Term]
id: GO:0006782
name: protoporphyrinogen IX biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX." [GOC:go_curators]
subset: gosubset_prok
synonym: "protoporphyrinogen IX anabolism" EXACT []
synonym: "protoporphyrinogen IX biosynthesis" EXACT []
synonym: "protoporphyrinogen IX formation" EXACT []
synonym: "protoporphyrinogen IX synthesis" EXACT []
is_a: GO:0006779 ! porphyrin-containing compound biosynthetic process
is_a: GO:0046501 ! protoporphyrinogen IX metabolic process
relationship: part_of GO:0006783 ! heme biosynthetic process

[Term]
id: GO:0006783
name: heme biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors." [GOC:jl]
subset: gosubset_prok
synonym: "haem biosynthesis" EXACT []
synonym: "haem biosynthetic process" EXACT []
synonym: "heme anabolism" EXACT []
synonym: "heme biosynthesis" EXACT []
synonym: "heme formation" EXACT []
synonym: "heme synthesis" EXACT []
xref: MetaCyc:HEMESYN2-PWY
xref: Reactome:REACT_103117 "Heme biosynthesis, Xenopus tropicalis"
xref: Reactome:REACT_108806 "Heme biosynthesis, Bos taurus"
xref: Reactome:REACT_115611 "Heme synthesis, Gallus gallus"
xref: Reactome:REACT_31279 "Heme biosynthesis, Plasmodium falciparum"
xref: Reactome:REACT_32048 "Heme biosynthesis, Danio rerio"
xref: Reactome:REACT_33762 "Heme biosynthesis, Arabidopsis thaliana"
xref: Reactome:REACT_34363 "Heme biosynthesis, Schizosaccharomyces pombe"
xref: Reactome:REACT_77747 "Heme biosynthesis, Canis familiaris"
xref: Reactome:REACT_78621 "Heme biosynthesis, Rattus norvegicus"
xref: Reactome:REACT_81550 "Heme biosynthesis, Oryza sativa"
xref: Reactome:REACT_83388 "Heme biosynthesis, Sus scrofa"
xref: Reactome:REACT_83502 "Heme biosynthesis, Mycobacterium tuberculosis"
xref: Reactome:REACT_84579 "Heme biosynthesis, Taeniopygia guttata"
xref: Reactome:REACT_88226 "Heme biosynthesis, Dictyostelium discoideum"
xref: Reactome:REACT_88314 "Heme biosynthesis, Drosophila melanogaster"
xref: Reactome:REACT_9465 "Heme biosynthesis, Homo sapiens"
xref: Reactome:REACT_96583 "Heme biosynthesis, Saccharomyces cerevisiae"
xref: Reactome:REACT_96932 "Heme biosynthesis, Staphylococcus aureus N315"
xref: Reactome:REACT_98337 "Heme biosynthesis, Gallus gallus"
xref: Reactome:REACT_98999 "Heme biosynthesis, Escherichia coli"
xref: Reactome:REACT_99419 "Heme biosynthesis, Mus musculus"
is_a: GO:0006779 ! porphyrin-containing compound biosynthetic process
is_a: GO:0042168 ! heme metabolic process
is_a: GO:0046148 ! pigment biosynthetic process

[Term]
id: GO:0006784
name: heme a biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of heme a, a derivative of heme found in cytochrome aa3." [CHEBI:24479, GOC:ai]
subset: gosubset_prok
synonym: "haem a biosynthesis" EXACT []
synonym: "haem a biosynthetic process" EXACT []
synonym: "heme a anabolism" EXACT []
synonym: "heme a biosynthesis" EXACT []
synonym: "heme a formation" EXACT []
synonym: "heme a synthesis" EXACT []
is_a: GO:0006783 ! heme biosynthetic process
is_a: GO:0046160 ! heme a metabolic process

[Term]
id: GO:0006785
name: heme b biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of heme b, a Fe(II) porphyrin complex readily isolated from the hemoglobin of beef blood, but also found in other proteins including other hemoglobins, myoglobins, cytochromes P-450, catalases, peroxidases as well as b type cytochromes." [GOC:yaf, http://www.chem.qmul.ac.uk/iupac/bioinorg/PR.html#25, UniPathway:UPA00252]
subset: gosubset_prok
synonym: "haem b biosynthesis" EXACT []
synonym: "haem b biosynthetic process" EXACT []
synonym: "heme b anabolism" EXACT []
synonym: "heme b biosynthesis" EXACT []
synonym: "heme b formation" EXACT []
synonym: "heme b synthesis" EXACT []
synonym: "protoheme biosynthesis" EXACT []
synonym: "protoheme biosynthetic process" EXACT []
is_a: GO:0006783 ! heme biosynthetic process
is_a: GO:0046492 ! heme b metabolic process

[Term]
id: GO:0006786
name: heme c biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of heme c, a derivative of heme found in cytochromes c, b4, and f." [GOC:curators, PubChem_Compound:122208]
subset: gosubset_prok
synonym: "haem c biosynthesis" EXACT []
synonym: "haem c biosynthetic process" EXACT []
synonym: "heme c anabolism" EXACT []
synonym: "heme c biosynthesis" EXACT []
synonym: "heme c formation" EXACT []
synonym: "heme c synthesis" EXACT []
is_a: GO:0006783 ! heme biosynthetic process
is_a: GO:0046162 ! heme c metabolic process

[Term]
id: GO:0006787
name: porphyrin-containing compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "porphyrin breakdown" RELATED []
synonym: "porphyrin catabolic process" RELATED []
synonym: "porphyrin catabolism" RELATED []
synonym: "porphyrin degradation" RELATED []
is_a: GO:0006778 ! porphyrin-containing compound metabolic process
is_a: GO:0033015 ! tetrapyrrole catabolic process
is_a: GO:0051187 ! cofactor catabolic process

[Term]
id: GO:0006788
name: heme oxidation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the loss of electrons from one or more atoms in heme." [GOC:mah]
subset: gosubset_prok
synonym: "haem oxidation" EXACT []
is_a: GO:0042168 ! heme metabolic process
is_a: GO:0055114 ! oxidation-reduction process
relationship: part_of GO:0006787 ! porphyrin-containing compound catabolic process

[Term]
id: GO:0006789
name: bilirubin conjugation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of bilirubin monoglucuronide or bilirubin diglucuronide, water-soluble derivatives of bilirubin." [DOI:10.1016/0305-0491(80)90243-6]
subset: gosubset_prok
xref: Reactome:REACT_100951 "bilirubin + UDP-glucuronic acid => bilirubin monoglucuronide + UDP, Bos taurus"
xref: Reactome:REACT_109353 "bilirubin + UDP-glucuronic acid => bilirubin monoglucuronide + UDP, Taeniopygia guttata"
xref: Reactome:REACT_113946 "bilirubin + UDP-glucuronic acid => bilirubin monoglucuronide + UDP, Caenorhabditis elegans"
xref: Reactome:REACT_22274 "bilirubin + UDP-glucuronic acid => bilirubin monoglucuronide + UDP, Homo sapiens"
xref: Reactome:REACT_80868 "bilirubin + UDP-glucuronic acid => bilirubin monoglucuronide + UDP, Mus musculus"
xref: Reactome:REACT_82682 "bilirubin + UDP-glucuronic acid => bilirubin monoglucuronide + UDP, Rattus norvegicus"
xref: Reactome:REACT_96239 "bilirubin + UDP-glucuronic acid => bilirubin monoglucuronide + UDP, Sus scrofa"
xref: Reactome:REACT_96288 "bilirubin + UDP-glucuronic acid => bilirubin monoglucuronide + UDP, Danio rerio"
is_a: GO:0006787 ! porphyrin-containing compound catabolic process

[Term]
id: GO:0006790
name: sulfur compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:ai]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: gosubset_prok
synonym: "sulfur metabolism" EXACT []
synonym: "sulphur metabolic process" EXACT []
synonym: "sulphur metabolism" EXACT []
xref: Reactome:REACT_27247 "Sulfur compound metabolism, Mycobacterium tuberculosis"
xref: Wikipedia:Sulfur_metabolism
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0006791
name: sulfur utilization
namespace: biological_process
def: "A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary sulfur sources and then activates genes to scavenge the last traces of the primary sulfur source and to transport and metabolize alternate sulfur sources. The utilization process begins when the cell or organism detects sulfur levels, includes the activation of genes whose products detect, transport or metabolize sulfur-containing compounds, and ends when the sulfur is incorporated into the cell or organism's metabolism." [GOC:mah, GOC:mlg]
subset: gosubset_prok
synonym: "sulphur utilization" EXACT []
is_a: GO:0044699 ! single-organism process
relationship: has_part GO:0006790 ! sulfur compound metabolic process

[Term]
id: GO:0006792
name: regulation of sulfur utilization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sulfur utilization." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of sulphur utilization" EXACT []
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006791 ! sulfur utilization
relationship: regulates GO:0006791 ! sulfur utilization

[Term]
id: GO:0006793
name: phosphorus metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus, usually in the form of a phosphate group (PO4)." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "phosphorus metabolism" EXACT []
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0006794
name: phosphorus utilization
namespace: biological_process
def: "A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary phosphorus source and then activates genes to scavenge the last traces of the primary phosphorus source and to transport and metabolize alternative phosphorus sources. The utilization process begins when the cell or organism detects phosphorus levels, includes the phosphorus-containing substances, and ends when phosphorus is incorporated into the cell or organism's metabolism." [GOC:mah, GOC:mlg]
subset: gosubset_prok
is_a: GO:0044699 ! single-organism process
relationship: has_part GO:0006793 ! phosphorus metabolic process

[Term]
id: GO:0006795
name: regulation of phosphorus utilization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phosphorus utilization." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006794 ! phosphorus utilization
relationship: regulates GO:0006794 ! phosphorus utilization

[Term]
id: GO:0006796
name: phosphate-containing compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai]
subset: gosubset_prok
synonym: "phosphate metabolic process" RELATED []
synonym: "phosphate metabolism" EXACT []
is_a: GO:0006793 ! phosphorus metabolic process

[Term]
id: GO:0006797
name: polyphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a polyphosphate, the anion or salt of polyphosphoric acid." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "polyphosphate metabolism" EXACT []
is_a: GO:0006793 ! phosphorus metabolic process
is_a: GO:0043436 ! oxoacid metabolic process

[Term]
id: GO:0006798
name: polyphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a polyphosphate, the anion or salt of polyphosphoric acid." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "polyphosphate breakdown" EXACT []
synonym: "polyphosphate catabolism" EXACT []
synonym: "polyphosphate degradation" EXACT []
is_a: GO:0006797 ! polyphosphate metabolic process
is_a: GO:0044248 ! cellular catabolic process
is_a: GO:0044712 ! single-organism catabolic process
is_a: GO:1901575 ! organic substance catabolic process

[Term]
id: GO:0006799
name: polyphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a polyphosphate, the anion or salt of polyphosphoric acid." [ISBN:0198506732]
subset: gosubset_prok
synonym: "polyphosphate anabolism" EXACT []
synonym: "polyphosphate biosynthesis" EXACT []
synonym: "polyphosphate formation" EXACT []
synonym: "polyphosphate synthesis" EXACT []
is_a: GO:0006797 ! polyphosphate metabolic process
is_a: GO:0044249 ! cellular biosynthetic process
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:1901576 ! organic substance biosynthetic process

[Term]
id: GO:0006800
name: obsolete oxygen and reactive oxygen species metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving dioxygen (O2), or any of the reactive oxygen species, e.g. superoxide anions (O2-), hydrogen peroxide (H2O2), and hydroxyl radicals (-OH)." [GOC:jl, PMID:12115731]
comment: This term was made obsolete because, as part of the GO/ChEBI alignment effort, curators determined that oxygen and reactive oxygen species should not be grouped together.
synonym: "oxygen and active oxygen species metabolism" EXACT []
synonym: "oxygen and AOS metabolism" EXACT []
synonym: "oxygen and reactive oxidative species metabolism" EXACT []
synonym: "oxygen and reactive oxygen intermediate metabolism" EXACT []
synonym: "oxygen and reactive oxygen species metabolic process" EXACT []
synonym: "oxygen and reactive oxygen species metabolism" EXACT []
synonym: "oxygen and ROI metabolism" EXACT []
synonym: "oxygen and ROS metabolic process" EXACT []
synonym: "oxygen and ROS metabolism" EXACT []
is_obsolete: true
consider: GO:0072592
consider: GO:0072593

[Term]
id: GO:0006801
name: superoxide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species." [CHEBI:18421, GOC:jl]
subset: gosubset_prok
synonym: "oxygen free radical metabolic process" EXACT []
synonym: "oxygen free radical metabolism" EXACT []
synonym: "superoxide free radical metabolic process" EXACT []
synonym: "superoxide free radical metabolism" EXACT []
synonym: "superoxide metabolism" EXACT []
is_a: GO:0072593 ! reactive oxygen species metabolic process

[Term]
id: GO:0006802
name: obsolete catalase reaction
namespace: biological_process
def: "OBSOLETE. The processes involved in the induction or activation of catalase, an enzyme that catalyzes the conversion of H2O2 into H2O." [GOC:jl, PMID:11245904]
comment: This term was made obsolete because it represents a molecular function.
synonym: "catalase reaction" EXACT []
synonym: "hydroperoxidase reaction" RELATED []
is_obsolete: true
consider: GO:0004096

[Term]
id: GO:0006803
name: obsolete glutathione conjugation reaction
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function and not a biological process.
synonym: "glutathione conjugation reaction" EXACT []
is_obsolete: true
replaced_by: GO:0004364

[Term]
id: GO:0006804
name: obsolete peroxidase reaction
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function.
synonym: "peroxidase reaction" EXACT []
is_obsolete: true
replaced_by: GO:0004601

[Term]
id: GO:0006805
name: xenobiotic metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide." [GOC:cab2]
subset: goslim_chembl
subset: goslim_pir
subset: gosubset_prok
synonym: "xenobiotic metabolism" EXACT []
xref: Reactome:REACT_100124 "Conjugation of benzoate with glycine, Mus musculus"
xref: Reactome:REACT_100325 "Conjugation of phenylacetate with glutamine, Mus musculus"
xref: Reactome:REACT_100603 "Biological oxidations, Arabidopsis thaliana"
xref: Reactome:REACT_101131 "Phase 1 - Functionalization of compounds, Dictyostelium discoideum"
xref: Reactome:REACT_101207 "Phase II conjugation, Bos taurus"
xref: Reactome:REACT_101609 "Conjugation of benzoate with glycine, Staphylococcus aureus N315"
xref: Reactome:REACT_102115 "Phase 1 - Functionalization of compounds, Schizosaccharomyces pombe"
xref: Reactome:REACT_102424 "Phase 1 - Functionalization of compounds, Danio rerio"
xref: Reactome:REACT_102433 "Conjugation of salicylate with glycine, Sus scrofa"
xref: Reactome:REACT_102710 "Phase II conjugation, Drosophila melanogaster"
xref: Reactome:REACT_102875 "Conjugation of phenylacetate with glutamine, Bos taurus"
xref: Reactome:REACT_103896 "Phase 1 - Functionalization of compounds, Saccharomyces cerevisiae"
xref: Reactome:REACT_104199 "Phase II conjugation, Staphylococcus aureus N315"
xref: Reactome:REACT_104666 "Phase 1 - Functionalization of compounds, Arabidopsis thaliana"
xref: Reactome:REACT_104877 "Conjugation of carboxylic acids, Canis familiaris"
xref: Reactome:REACT_105707 "Phase 1 - Functionalization of compounds, Canis familiaris"
xref: Reactome:REACT_106111 "Phase II conjugation, Schizosaccharomyces pombe"
xref: Reactome:REACT_106484 "Conjugation of salicylate with glycine, Danio rerio"
xref: Reactome:REACT_106812 "Biological oxidations, Staphylococcus aureus N315"
xref: Reactome:REACT_108383 "Phase 1 - Functionalization of compounds, Gallus gallus"
xref: Reactome:REACT_110034 "Biological oxidations, Saccharomyces cerevisiae"
xref: Reactome:REACT_110188 "Conjugation of phenylacetate with glutamine, Rattus norvegicus"
xref: Reactome:REACT_110735 "Conjugation of salicylate with glycine, Canis familiaris"
xref: Reactome:REACT_110771 "Phase II conjugation, Saccharomyces cerevisiae"
xref: Reactome:REACT_110976 "Biological oxidations, Sus scrofa"
xref: Reactome:REACT_112180 "Conjugation of phenylacetate with glutamine, Dictyostelium discoideum"
xref: Reactome:REACT_112300 "Amino Acid conjugation, Dictyostelium discoideum"
xref: Reactome:REACT_112424 "Conjugation of salicylate with glycine, Dictyostelium discoideum"
xref: Reactome:REACT_114132 "Conjugation of benzoate with glycine, Dictyostelium discoideum"
xref: Reactome:REACT_115263 "Phase 1 - Functionalization of compounds, Escherichia coli"
xref: Reactome:REACT_115368 "Conjugation of carboxylic acids, Dictyostelium discoideum"
xref: Reactome:REACT_13433 "Biological oxidations, Homo sapiens"
xref: Reactome:REACT_13705 "Phase 1 - Functionalization of compounds, Homo sapiens"
xref: Reactome:REACT_30367 "Conjugation of carboxylic acids, Danio rerio"
xref: Reactome:REACT_30613 "Amino Acid conjugation, Canis familiaris"
xref: Reactome:REACT_31665 "Phase II conjugation, Caenorhabditis elegans"
xref: Reactome:REACT_32556 "Biological oxidations, Escherichia coli"
xref: Reactome:REACT_32957 "Conjugation of phenylacetate with glutamine, Sus scrofa"
xref: Reactome:REACT_33042 "Phase II conjugation, Xenopus tropicalis"
xref: Reactome:REACT_33621 "Biological oxidations, Canis familiaris"
xref: Reactome:REACT_33687 "Phase 1 - Functionalization of compounds, Drosophila melanogaster"
xref: Reactome:REACT_34424 "Biological oxidations, Plasmodium falciparum"
xref: Reactome:REACT_43989 "Phase II conjugation, Gallus gallus"
xref: Reactome:REACT_6800 "Conjugation of phenylacetate with glutamine, Homo sapiens"
xref: Reactome:REACT_6812 "Conjugation of salicylate with glycine, Homo sapiens"
xref: Reactome:REACT_6889 "Conjugation of carboxylic acids, Homo sapiens"
xref: Reactome:REACT_6933 "Conjugation of benzoate with glycine, Homo sapiens"
xref: Reactome:REACT_6959 "Phase II conjugation, Homo sapiens"
xref: Reactome:REACT_6971 "Amino Acid conjugation, Homo sapiens"
xref: Reactome:REACT_76924 "Biological oxidations, Bos taurus"
xref: Reactome:REACT_76938 "Phase II conjugation, Canis familiaris"
xref: Reactome:REACT_77460 "Phase II conjugation, Danio rerio"
xref: Reactome:REACT_77547 "Phase 1 - Functionalization of compounds, Oryza sativa"
xref: Reactome:REACT_77582 "Biological oxidations, Taeniopygia guttata"
xref: Reactome:REACT_77645 "Phase 1 - Functionalization of compounds, Mus musculus"
xref: Reactome:REACT_78106 "Biological oxidations, Drosophila melanogaster"
xref: Reactome:REACT_78563 "Phase 1 - Functionalization of compounds, Sus scrofa"
xref: Reactome:REACT_78673 "Amino Acid conjugation, Staphylococcus aureus N315"
xref: Reactome:REACT_78750 "Phase 1 - Functionalization of compounds, Taeniopygia guttata"
xref: Reactome:REACT_79195 "Conjugation of salicylate with glycine, Mus musculus"
xref: Reactome:REACT_80247 "Biological oxidations, Dictyostelium discoideum"
xref: Reactome:REACT_80647 "Biological oxidations, Xenopus tropicalis"
xref: Reactome:REACT_81143 "Biological oxidations, Mus musculus"
xref: Reactome:REACT_81813 "Amino Acid conjugation, Mus musculus"
xref: Reactome:REACT_82058 "Phase II conjugation, Escherichia coli"
xref: Reactome:REACT_82657 "Biological oxidations, Rattus norvegicus"
xref: Reactome:REACT_82846 "Phase II conjugation, Plasmodium falciparum"
xref: Reactome:REACT_83594 "Phase II conjugation, Taeniopygia guttata"
xref: Reactome:REACT_83912 "Amino Acid conjugation, Bos taurus"
xref: Reactome:REACT_83999 "Biological oxidations, Oryza sativa"
xref: Reactome:REACT_84336 "Phase 1 - Functionalization of compounds, Caenorhabditis elegans"
xref: Reactome:REACT_84559 "Phase 1 - Functionalization of compounds, Xenopus tropicalis"
xref: Reactome:REACT_84880 "Conjugation of carboxylic acids, Sus scrofa"
xref: Reactome:REACT_86049 "Conjugation of carboxylic acids, Bos taurus"
xref: Reactome:REACT_87255 "Phase II conjugation, Oryza sativa"
xref: Reactome:REACT_87382 "Phase II conjugation, Mycobacterium tuberculosis"
xref: Reactome:REACT_87394 "Amino Acid conjugation, Sus scrofa"
xref: Reactome:REACT_87515 "Phase 1 - Functionalization of compounds, Bos taurus"
xref: Reactome:REACT_87608 "Phase II conjugation, Mus musculus"
xref: Reactome:REACT_88305 "Amino Acid conjugation, Danio rerio"
xref: Reactome:REACT_88538 "Conjugation of salicylate with glycine, Rattus norvegicus"
xref: Reactome:REACT_89162 "Biological oxidations, Gallus gallus"
xref: Reactome:REACT_89167 "Phase II conjugation, Sus scrofa"
xref: Reactome:REACT_89372 "Biological oxidations, Danio rerio"
xref: Reactome:REACT_89381 "Conjugation of benzoate with glycine, Sus scrofa"
xref: Reactome:REACT_89411 "Phase II conjugation, Arabidopsis thaliana"
xref: Reactome:REACT_89902 "Biological oxidations, Mycobacterium tuberculosis"
xref: Reactome:REACT_89981 "Conjugation of benzoate with glycine, Danio rerio"
xref: Reactome:REACT_90526 "Biological oxidations, Caenorhabditis elegans"
xref: Reactome:REACT_90693 "Conjugation of phenylacetate with glutamine, Canis familiaris"
xref: Reactome:REACT_93150 "Amino Acid conjugation, Rattus norvegicus"
xref: Reactome:REACT_93320 "Biological oxidations, Schizosaccharomyces pombe"
xref: Reactome:REACT_93377 "Conjugation of carboxylic acids, Rattus norvegicus"
xref: Reactome:REACT_94407 "Phase 1 - Functionalization of compounds, Mycobacterium tuberculosis"
xref: Reactome:REACT_94419 "Conjugation of carboxylic acids, Staphylococcus aureus N315"
xref: Reactome:REACT_95660 "Phase II conjugation, Rattus norvegicus"
xref: Reactome:REACT_96794 "Phase II conjugation, Dictyostelium discoideum"
xref: Reactome:REACT_96971 "Conjugation of carboxylic acids, Mus musculus"
xref: Reactome:REACT_97920 "Conjugation of salicylate with glycine, Bos taurus"
xref: Reactome:REACT_98166 "Conjugation of benzoate with glycine, Canis familiaris"
xref: Reactome:REACT_98222 "Conjugation of benzoate with glycine, Rattus norvegicus"
xref: Reactome:REACT_98651 "Conjugation of benzoate with glycine, Bos taurus"
xref: Reactome:REACT_99593 "Conjugation of salicylate with glycine, Staphylococcus aureus N315"
xref: Reactome:REACT_99671 "Conjugation of phenylacetate with glutamine, Staphylococcus aureus N315"
xref: Reactome:REACT_99818 "Phase 1 - Functionalization of compounds, Rattus norvegicus"
xref: Wikipedia:Xenobiotic_metabolism
is_a: GO:0044237 ! cellular metabolic process
relationship: part_of GO:0071466 ! cellular response to xenobiotic stimulus

[Term]
id: GO:0006806
name: obsolete insecticide resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process.
synonym: "insecticide resistance" EXACT []
is_obsolete: true
replaced_by: GO:0017085

[Term]
id: GO:0006807
name: nitrogen compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen, including (but not limited to) nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium." [CHEBI:51143, GOC:go_curators, GOC:jl, ISBN:0198506732]
comment: Note that amino acid and derivative metabolism should not be annotated here. Instead use the 'amino acid and derivative metabolism' node.
subset: goslim_metagenomics
subset: goslim_pir
subset: gosubset_prok
synonym: "nitrogen compound metabolism" EXACT []
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0006808
name: regulation of nitrogen utilization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nitrogen utilization." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019740 ! nitrogen utilization
relationship: regulates GO:0019740 ! nitrogen utilization

[Term]
id: GO:0006809
name: nitric oxide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water." [GOC:ai]
subset: gosubset_prok
synonym: "nitric oxide anabolism" EXACT []
synonym: "nitric oxide biosynthesis" EXACT []
synonym: "nitric oxide formation" EXACT []
synonym: "nitric oxide synthesis" EXACT []
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process
is_a: GO:0046209 ! nitric oxide metabolic process
is_a: GO:1903409 ! reactive oxygen species biosynthetic process

[Term]
id: GO:0006810
name: transport
namespace: biological_process
alt_id: GO:0015457
alt_id: GO:0015460
def: "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "auxiliary transport protein activity" RELATED [GOC:mah]
synonym: "small molecule transport" NARROW []
synonym: "solute:solute exchange" NARROW []
synonym: "transport accessory protein activity" RELATED [GOC:mah]
is_a: GO:0051234 ! establishment of localization

[Term]
id: GO:0006811
name: ion transport
namespace: biological_process
def: "The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
xref: Reactome:REACT_102356 "Transport of inorganic cations/anions and amino acids/oligopeptides, Xenopus tropicalis"
xref: Reactome:REACT_102895 "Transport of inorganic cations/anions and amino acids/oligopeptides, Staphylococcus aureus N315"
xref: Reactome:REACT_106972 "Transport of inorganic cations/anions and amino acids/oligopeptides, Sus scrofa"
xref: Reactome:REACT_109067 "Transport of inorganic cations/anions and amino acids/oligopeptides, Saccharomyces cerevisiae"
xref: Reactome:REACT_110862 "Transport of inorganic cations/anions and amino acids/oligopeptides, Arabidopsis thaliana"
xref: Reactome:REACT_19397 "Transport of inorganic cations/anions and amino acids/oligopeptides, Homo sapiens"
xref: Reactome:REACT_29110 "Transport of inorganic cations/anions and amino acids/oligopeptides, Oryza sativa"
xref: Reactome:REACT_31978 "Transport of inorganic cations/anions and amino acids/oligopeptides, Mus musculus"
xref: Reactome:REACT_33992 "Transport of inorganic cations/anions and amino acids/oligopeptides, Danio rerio"
xref: Reactome:REACT_34201 "Transport of inorganic cations/anions and amino acids/oligopeptides, Gallus gallus"
xref: Reactome:REACT_79109 "Transport of inorganic cations/anions and amino acids/oligopeptides, Caenorhabditis elegans"
xref: Reactome:REACT_82618 "Transport of inorganic cations/anions and amino acids/oligopeptides, Escherichia coli"
xref: Reactome:REACT_87822 "Transport of inorganic cations/anions and amino acids/oligopeptides, Bos taurus"
xref: Reactome:REACT_91472 "Transport of inorganic cations/anions and amino acids/oligopeptides, Dictyostelium discoideum"
xref: Reactome:REACT_91958 "Transport of inorganic cations/anions and amino acids/oligopeptides, Drosophila melanogaster"
xref: Reactome:REACT_92903 "Transport of inorganic cations/anions and amino acids/oligopeptides, Mycobacterium tuberculosis"
xref: Reactome:REACT_93485 "Transport of inorganic cations/anions and amino acids/oligopeptides, Canis familiaris"
xref: Reactome:REACT_94357 "Transport of inorganic cations/anions and amino acids/oligopeptides, Rattus norvegicus"
xref: Reactome:REACT_96078 "Transport of inorganic cations/anions and amino acids/oligopeptides, Plasmodium falciparum"
xref: Reactome:REACT_96919 "Transport of inorganic cations/anions and amino acids/oligopeptides, Taeniopygia guttata"
xref: Reactome:REACT_98077 "Transport of inorganic cations/anions and amino acids/oligopeptides, Schizosaccharomyces pombe"
is_a: GO:0044765 ! single-organism transport

[Term]
id: GO:0006812
name: cation transport
namespace: biological_process
alt_id: GO:0006819
alt_id: GO:0015674
def: "The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "di-, tri-valent inorganic cation transport" NARROW [GOC:mah]
is_a: GO:0006811 ! ion transport

[Term]
id: GO:0006813
name: potassium ion transport
namespace: biological_process
alt_id: GO:0015458
def: "The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "K+ conductance" EXACT []
synonym: "low voltage-dependent potassium channel auxiliary protein activity" RELATED [GOC:mah]
synonym: "low voltage-gated potassium channel auxiliary protein activity" RELATED [GOC:mah]
synonym: "potassium conductance" NARROW []
synonym: "potassium ion conductance" NARROW []
synonym: "potassium transport" EXACT []
synonym: "sodium/potassium transport" BROAD []
is_a: GO:0015672 ! monovalent inorganic cation transport
is_a: GO:0030001 ! metal ion transport

[Term]
id: GO:0006814
name: sodium ion transport
namespace: biological_process
alt_id: GO:0006834
alt_id: GO:0016974
def: "The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "mitochondrial sodium/calcium ion exchange" NARROW []
synonym: "sodium channel auxiliary protein activity" RELATED [GOC:mah]
synonym: "sodium transport" EXACT []
synonym: "sodium/potassium transport" BROAD []
synonym: "sodium:calcium exchange" NARROW []
synonym: "sodium:solute transport" NARROW []
is_a: GO:0015672 ! monovalent inorganic cation transport
is_a: GO:0030001 ! metal ion transport

[Term]
id: GO:0006815
name: obsolete sodium/potassium transport
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it is a composite term that represents two individual processes.
synonym: "sodium/potassium transport" EXACT []
is_obsolete: true
consider: GO:0006813
consider: GO:0006814

[Term]
id: GO:0006816
name: calcium ion transport
namespace: biological_process
def: "The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "calcium transport" EXACT []
synonym: "mitochondrial sodium/calcium ion exchange" NARROW []
synonym: "sodium:calcium exchange" NARROW []
is_a: GO:0070838 ! divalent metal ion transport

[Term]
id: GO:0006817
name: phosphate ion transport
namespace: biological_process
def: "The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
subset: gosubset_prok
synonym: "phosphate transport" RELATED []
is_a: GO:0015698 ! inorganic anion transport

[Term]
id: GO:0006818
name: hydrogen transport
namespace: biological_process
def: "The directed movement of hydrogen (H2 or H+), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0044765 ! single-organism transport

[Term]
id: GO:0006820
name: anion transport
namespace: biological_process
alt_id: GO:0006822
def: "The directed movement of anions, atoms or small molecules with a net negative charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006811 ! ion transport

[Term]
id: GO:0006821
name: chloride transport
namespace: biological_process
def: "The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
subset: gosubset_prok
is_a: GO:0015698 ! inorganic anion transport

[Term]
id: GO:0006823
name: obsolete heavy metal ion transport
namespace: biological_process
def: "OBSOLETE. The directed movement of heavy metal ions into, out of or within a cell, or between cells. Heavy metals are those that can form a coordination bond with a protein, as opposed to an alkali or alkaline-earth metal that can only form an ionic bond; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn." [GOC:kd, GOC:mah]
comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information).
synonym: "heavy metal ion transport" EXACT []
is_obsolete: true
consider: GO:0030001

[Term]
id: GO:0006824
name: cobalt ion transport
namespace: biological_process
def: "The directed movement of cobalt (Co) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "cobalt transport" EXACT []
is_a: GO:0000041 ! transition metal ion transport
is_a: GO:0072511 ! divalent inorganic cation transport

[Term]
id: GO:0006825
name: copper ion transport
namespace: biological_process
def: "The directed movement of copper (Cu) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
is_a: GO:0000041 ! transition metal ion transport

[Term]
id: GO:0006826
name: iron ion transport
namespace: biological_process
alt_id: GO:0015681
def: "The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "iron transport" EXACT []
is_a: GO:0000041 ! transition metal ion transport

[Term]
id: GO:0006827
name: high-affinity iron ion transmembrane transport
namespace: biological_process
def: "A process in which an iron ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mah]
subset: gosubset_prok
synonym: "high affinity iron ion transport" BROAD []
synonym: "high-affinity iron ion transport" BROAD []
is_a: GO:0034755 ! iron ion transmembrane transport

[Term]
id: GO:0006828
name: manganese ion transport
namespace: biological_process
def: "The directed movement of manganese (Mn) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
is_a: GO:0000041 ! transition metal ion transport

[Term]
id: GO:0006829
name: zinc II ion transport
namespace: biological_process
def: "The directed movement of zinc (Zn II) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "zinc transport" EXACT [GOC:mah]
is_a: GO:0000041 ! transition metal ion transport
is_a: GO:0070838 ! divalent metal ion transport

[Term]
id: GO:0006830
name: high-affinity zinc II ion transport
namespace: biological_process
def: "The directed, high-affinity movement of zinc (Zn II) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mah]
is_a: GO:0071577 ! zinc II ion transmembrane transport

[Term]
id: GO:0006831
name: low-affinity zinc II ion transport
namespace: biological_process
def: "The directed, low-affinity movement of zinc (Zn II) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. In low-affinity transport the transporter is able to bind the solute only if it is only present at very low concentrations." [GOC:mah]
is_a: GO:0071577 ! zinc II ion transmembrane transport

[Term]
id: GO:0006832
name: obsolete small molecule transport
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "small molecule transport" EXACT []
is_obsolete: true
consider: GO:0006810

[Term]
id: GO:0006833
name: water transport
namespace: biological_process
def: "The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
xref: Reactome:REACT_100323 "Passive Transport by Aquaporins, Saccharomyces cerevisiae"
xref: Reactome:REACT_100926 "Regulation of Water Balance by Renal Aquaporins, Gallus gallus"
xref: Reactome:REACT_101470 "Aquaporin-mediated transport, Canis familiaris"
xref: Reactome:REACT_102276 "Aquaporin-mediated transport, Dictyostelium discoideum"
xref: Reactome:REACT_104925 "Passive Transport by Aquaporins, Xenopus tropicalis"
xref: Reactome:REACT_106426 "Regulation of Water Balance by Renal Aquaporins, Rattus norvegicus"
xref: Reactome:REACT_107038 "Regulation of Water Balance by Renal Aquaporins, Caenorhabditis elegans"
xref: Reactome:REACT_107112 "Aquaporin-mediated transport, Mus musculus"
xref: Reactome:REACT_108009 "Aquaporin-mediated transport, Saccharomyces cerevisiae"
xref: Reactome:REACT_108199 "Regulation of Water Balance by Renal Aquaporins, Plasmodium falciparum"
xref: Reactome:REACT_108998 "Regulation of Water Balance by Renal Aquaporins, Xenopus tropicalis"
xref: Reactome:REACT_109077 "Aquaporin-mediated transport, Bos taurus"
xref: Reactome:REACT_109206 "Aquaporin-mediated transport, Danio rerio"
xref: Reactome:REACT_110412 "Aquaporin-mediated transport, Rattus norvegicus"
xref: Reactome:REACT_112337 "Passive Transport by Aquaporins, Escherichia coli"
xref: Reactome:REACT_113611 "Passive Transport by Aquaporins, Drosophila melanogaster"
xref: Reactome:REACT_23826 "Passive Transport by Aquaporins, Homo sapiens"
xref: Reactome:REACT_23887 "Aquaporin-mediated transport, Homo sapiens"
xref: Reactome:REACT_24023 "Regulation of Water Balance by Renal Aquaporins, Homo sapiens"
xref: Reactome:REACT_29327 "Passive Transport by Aquaporins, Rattus norvegicus"
xref: Reactome:REACT_30349 "Aquaporin-mediated transport, Escherichia coli"
xref: Reactome:REACT_30374 "Passive Transport by Aquaporins, Bos taurus"
xref: Reactome:REACT_31971 "Regulation of Water Balance by Renal Aquaporins, Taeniopygia guttata"
xref: Reactome:REACT_32279 "Aquaporin-mediated transport, Caenorhabditis elegans"
xref: Reactome:REACT_32908 "Regulation of Water Balance by Renal Aquaporins, Escherichia coli"
xref: Reactome:REACT_33949 "Aquaporin-mediated transport, Staphylococcus aureus N315"
xref: Reactome:REACT_34264 "Passive Transport by Aquaporins, Canis familiaris"
xref: Reactome:REACT_77599 "Passive Transport by Aquaporins, Mus musculus"
xref: Reactome:REACT_80678 "Aquaporin-mediated transport, Taeniopygia guttata"
xref: Reactome:REACT_80794 "Aquaporin-mediated transport, Sus scrofa"
xref: Reactome:REACT_82029 "Regulation of Water Balance by Renal Aquaporins, Schizosaccharomyces pombe"
xref: Reactome:REACT_83369 "Aquaporin-mediated transport, Drosophila melanogaster"
xref: Reactome:REACT_84018 "Aquaporin-mediated transport, Schizosaccharomyces pombe"
xref: Reactome:REACT_84275 "Regulation of Water Balance by Renal Aquaporins, Danio rerio"
xref: Reactome:REACT_84902 "Passive Transport by Aquaporins, Sus scrofa"
xref: Reactome:REACT_86198 "Regulation of Water Balance by Renal Aquaporins, Canis familiaris"
xref: Reactome:REACT_87355 "Aquaporin-mediated transport, Plasmodium falciparum"
xref: Reactome:REACT_89286 "Aquaporin-mediated transport, Gallus gallus"
xref: Reactome:REACT_90368 "Regulation of Water Balance by Renal Aquaporins, Bos taurus"
xref: Reactome:REACT_91961 "Regulation of Water Balance by Renal Aquaporins, Dictyostelium discoideum"
xref: Reactome:REACT_92364 "Regulation of Water Balance by Renal Aquaporins, Staphylococcus aureus N315"
xref: Reactome:REACT_95030 "Aquaporin-mediated transport, Xenopus tropicalis"
xref: Reactome:REACT_96766 "Regulation of Water Balance by Renal Aquaporins, Sus scrofa"
xref: Reactome:REACT_97951 "Regulation of Water Balance by Renal Aquaporins, Mus musculus"
xref: Reactome:REACT_98188 "Regulation of Water Balance by Renal Aquaporins, Saccharomyces cerevisiae"
xref: Reactome:REACT_99705 "Regulation of Water Balance by Renal Aquaporins, Drosophila melanogaster"
is_a: GO:0042044 ! fluid transport

[Term]
id: GO:0006835
name: dicarboxylic acid transport
namespace: biological_process
alt_id: GO:0006841
def: "The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
subset: gosubset_prok
synonym: "sodium:dicarboxylate transport" RELATED []
is_a: GO:0046942 ! carboxylic acid transport

[Term]
id: GO:0006836
name: neurotransmitter transport
namespace: biological_process
def: "The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai]
subset: goslim_pir
synonym: "sodium:neurotransmitter transport" NARROW []
is_a: GO:0044765 ! single-organism transport

[Term]
id: GO:0006837
name: serotonin transport
namespace: biological_process
def: "The directed movement of serotonin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems." [GOC:ai]
is_a: GO:0015696 ! ammonium transport
is_a: GO:0015844 ! monoamine transport
is_a: GO:0015850 ! organic hydroxy compound transport

[Term]
id: GO:0006838
name: obsolete allantoin/allantoate transport
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it is a composite term that represents two individual processes.
synonym: "allantoin/allantoate transport" EXACT []
is_obsolete: true
consider: GO:0015719
consider: GO:0015720

[Term]
id: GO:0006839
name: mitochondrial transport
namespace: biological_process
def: "Transport of substances into, out of or within a mitochondrion." [GOC:ai]
synonym: "mitochondrial alpha-ketoglutarate/malate transport" NARROW []
synonym: "mitochondrial aspartate/glutamate transport" NARROW []
synonym: "mitochondrial sodium/calcium ion exchange" NARROW []
is_a: GO:1902582 ! single-organism intracellular transport

[Term]
id: GO:0006840
name: obsolete mitochondrial alpha-ketoglutarate/malate transport
namespace: biological_process
def: "OBSOLETE. The directed movement of alpha-ketoglutarate and malate into, out of or within a mitochondrion." [GOC:ai]
comment: This term was made obsolete because it represents a function rather than a process.
synonym: "mitochondrial alpha-ketoglutarate/malate transport" EXACT []
synonym: "mitochondrial oxoglutarate/malate transport" EXACT []
is_obsolete: true
consider: GO:0006839
consider: GO:0015367
consider: GO:0015742
consider: GO:0015743

[Term]
id: GO:0006842
name: tricarboxylic acid transport
namespace: biological_process
def: "The directed movement of tricarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
subset: gosubset_prok
is_a: GO:0046942 ! carboxylic acid transport

[Term]
id: GO:0006843
name: mitochondrial citrate transport
namespace: biological_process
def: "The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of or within a mitochondrion." [GOC:ai]
is_a: GO:0006839 ! mitochondrial transport
is_a: GO:0015746 ! citrate transport

[Term]
id: GO:0006844
name: acyl carnitine transport
namespace: biological_process
def: "The directed movement of acyl carnitine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acyl carnitine is the condensation product of a carboxylic acid and carnitine and is the transport form for a fatty acid crossing the mitochondrial membrane." [GOC:ai]
is_a: GO:0015697 ! quaternary ammonium group transport
is_a: GO:0051181 ! cofactor transport

[Term]
id: GO:0006845
name: obsolete mitochondrial aspartate/glutamate transport
namespace: biological_process
def: "OBSOLETE. The directed movement of aspartate and glutamate into, out of or within a mitochondrion." [GOC:ai]
comment: This term was made obsolete because it represents a function rather than a process.
synonym: "mitochondrial aspartate/glutamate transport" EXACT []
is_obsolete: true
consider: GO:0006839
consider: GO:0015810
consider: GO:0015813

[Term]
id: GO:0006846
name: acetate transport
namespace: biological_process
def: "The directed movement of acetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
is_a: GO:0015718 ! monocarboxylic acid transport

[Term]
id: GO:0006847
name: plasma membrane acetate transport
namespace: biological_process
def: "The directed movement of acetate across a plasma membrane." [GOC:ai]
is_a: GO:0035433 ! acetate transmembrane transport

[Term]
id: GO:0006848
name: pyruvate transport
namespace: biological_process
def: "The directed movement of pyruvate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
is_a: GO:0015718 ! monocarboxylic acid transport

[Term]
id: GO:0006849
name: plasma membrane pyruvate transport
namespace: biological_process
def: "The directed movement of pyruvate, 2-oxopropanoate, across a plasma membrane." [GOC:ai]
is_a: GO:1901475 ! pyruvate transmembrane transport

[Term]
id: GO:0006850
name: mitochondrial pyruvate transport
namespace: biological_process
def: "The directed movement of pyruvate, 2-oxopropanoate, into, out of or within a mitochondrion." [GOC:ai]
is_a: GO:0006839 ! mitochondrial transport
is_a: GO:0006848 ! pyruvate transport

[Term]
id: GO:0006851
name: mitochondrial calcium ion transport
namespace: biological_process
def: "The directed movement of calcium ions (Ca2+) into, out of or within a mitochondrion." [GOC:ai]
synonym: "mitochondrial calcium transport" EXACT []
is_a: GO:0006816 ! calcium ion transport
is_a: GO:0006839 ! mitochondrial transport

[Term]
id: GO:0006852
name: obsolete mitochondrial sodium/calcium ion exchange
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents function rather than a process.
synonym: "mitochondrial sodium/calcium exchange" EXACT []
synonym: "mitochondrial sodium/calcium ion exchange" EXACT []
is_obsolete: true
consider: GO:0005432
consider: GO:0006814
consider: GO:0006816
consider: GO:0006839

[Term]
id: GO:0006853
name: carnitine shuttle
namespace: biological_process
def: "The transfer of acyl groups to and from acyl-CoA molecules to form O-acylcarnitine, which can exchange across the mitochondrial inner membrane with unacylated carnitine." [ISBN:0198547684]
comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'.
xref: Reactome:REACT_101666 "Import of palmitoyl-CoA into the mitochondrial matrix, Caenorhabditis elegans"
xref: Reactome:REACT_105633 "Import of palmitoyl-CoA into the mitochondrial matrix, Gallus gallus"
xref: Reactome:REACT_11082 "Import of palmitoyl-CoA into the mitochondrial matrix, Homo sapiens"
xref: Reactome:REACT_29485 "Import of palmitoyl-CoA into the mitochondrial matrix, Dictyostelium discoideum"
xref: Reactome:REACT_32410 "Import of palmitoyl-CoA into the mitochondrial matrix, Arabidopsis thaliana"
xref: Reactome:REACT_82389 "Import of palmitoyl-CoA into the mitochondrial matrix, Canis familiaris"
xref: Reactome:REACT_83004 "Import of palmitoyl-CoA into the mitochondrial matrix, Oryza sativa"
xref: Reactome:REACT_84030 "Import of palmitoyl-CoA into the mitochondrial matrix, Sus scrofa"
xref: Reactome:REACT_87308 "Import of palmitoyl-CoA into the mitochondrial matrix, Schizosaccharomyces pombe"
xref: Reactome:REACT_87938 "Import of palmitoyl-CoA into the mitochondrial matrix, Drosophila melanogaster"
xref: Reactome:REACT_88789 "Import of palmitoyl-CoA into the mitochondrial matrix, Danio rerio"
xref: Reactome:REACT_91550 "Import of palmitoyl-CoA into the mitochondrial matrix, Taeniopygia guttata"
xref: Reactome:REACT_92175 "Import of palmitoyl-CoA into the mitochondrial matrix, Saccharomyces cerevisiae"
xref: Reactome:REACT_94810 "Import of palmitoyl-CoA into the mitochondrial matrix, Rattus norvegicus"
xref: Reactome:REACT_95416 "Import of palmitoyl-CoA into the mitochondrial matrix, Bos taurus"
xref: Reactome:REACT_95571 "Import of palmitoyl-CoA into the mitochondrial matrix, Xenopus tropicalis"
xref: Reactome:REACT_98381 "Import of palmitoyl-CoA into the mitochondrial matrix, Mus musculus"
xref: Wikipedia:Carnitine#Role_in_fatty_acid_metabolism
is_a: GO:0015909 ! long-chain fatty acid transport
is_a: GO:0032365 ! intracellular lipid transport
is_a: GO:1902001 ! fatty acid transmembrane transport
is_a: GO:1902603 ! carnitine transmembrane transport
is_a: GO:1990542 ! mitochondrial transmembrane transport

[Term]
id: GO:0006854
name: obsolete ATP/ADP exchange
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a molecular function and not a biological process.
synonym: "ATP/ADP exchange" EXACT []
is_obsolete: true
replaced_by: GO:0005471

[Term]
id: GO:0006855
name: drug transmembrane transport
namespace: biological_process
def: "The process in which a drug is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:ai, GOC:bf]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
subset: gosubset_prok
synonym: "drug membrane transport" EXACT []
synonym: "multidrug transport" RELATED []
is_a: GO:0015893 ! drug transport
is_a: GO:0055085 ! transmembrane transport

[Term]
id: GO:0006856
name: eye pigment precursor transport
namespace: biological_process
def: "The directed movement of eye pigment precursors, the inactive forms of visual pigments, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0044765 ! single-organism transport
relationship: part_of GO:0048066 ! developmental pigmentation

[Term]
id: GO:0006857
name: oligopeptide transport
namespace: biological_process
def: "The directed movement of oligopeptides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0015833 ! peptide transport

[Term]
id: GO:0006858
name: extracellular transport
namespace: biological_process
def: "The transport of substances that occurs outside cells." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0006810 ! transport
intersection_of: GO:0006810 ! transport
intersection_of: occurs_in GO:0005576 ! extracellular region
relationship: occurs_in GO:0005576 ! extracellular region

[Term]
id: GO:0006859
name: extracellular carbohydrate transport
namespace: biological_process
def: "The directed extracellular movement of carbohydrates." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006858 ! extracellular transport
is_a: GO:0008643 ! carbohydrate transport
intersection_of: GO:0008643 ! carbohydrate transport
intersection_of: occurs_in GO:0005576 ! extracellular region
relationship: occurs_in GO:0005576 ! extracellular region

[Term]
id: GO:0006860
name: extracellular amino acid transport
namespace: biological_process
def: "The directed extracellular movement of amino acids." [GOC:ai]
is_a: GO:0006858 ! extracellular transport
is_a: GO:0006865 ! amino acid transport
intersection_of: GO:0006865 ! amino acid transport
intersection_of: occurs_in GO:0005576 ! extracellular region
relationship: occurs_in GO:0005576 ! extracellular region

[Term]
id: GO:0006862
name: nucleotide transport
namespace: biological_process
def: "The directed movement of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, into, out of or within a cell." [ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0015748 ! organophosphate ester transport
is_a: GO:0015931 ! nucleobase-containing compound transport

[Term]
id: GO:0006863
name: purine nucleobase transport
namespace: biological_process
alt_id: GO:0015852
def: "The directed movement of purine bases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:26386, ISBN:0198506732]
subset: gosubset_prok
synonym: "purine base transmembrane transport" EXACT [GOC:mah]
synonym: "purine base transport" EXACT [GOC:go_curators]
synonym: "purine transmembrane transport" RELATED [GOC:mah]
synonym: "purine transport" RELATED [GOC:curators]
is_a: GO:0015851 ! nucleobase transport

[Term]
id: GO:0006864
name: pyrimidine nucleotide transport
namespace: biological_process
def: "The directed movement of a pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate, into, out of or within a cell." [GOC:ai]
is_a: GO:0006862 ! nucleotide transport

[Term]
id: GO:0006865
name: amino acid transport
namespace: biological_process
alt_id: GO:0006866
def: "The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
xref: Reactome:REACT_104605 "Amino acid transport across the plasma membrane, Rattus norvegicus"
xref: Reactome:REACT_105142 "Amino acid transport across the plasma membrane, Mus musculus"
xref: Reactome:REACT_105179 "Amino acid transport across the plasma membrane, Caenorhabditis elegans"
xref: Reactome:REACT_106669 "Amino acid transport across the plasma membrane, Dictyostelium discoideum"
xref: Reactome:REACT_107151 "Amino acid transport across the plasma membrane, Arabidopsis thaliana"
xref: Reactome:REACT_107366 "Amino acid transport across the plasma membrane, Gallus gallus"
xref: Reactome:REACT_107449 "Amino acid transport across the plasma membrane, Escherichia coli"
xref: Reactome:REACT_112073 "Amino acid transport across the plasma membrane, Mycobacterium tuberculosis"
xref: Reactome:REACT_115423 "Amino acid transport across the plasma membrane, Saccharomyces cerevisiae"
xref: Reactome:REACT_13796 "Amino acid transport across the plasma membrane, Homo sapiens"
xref: Reactome:REACT_29020 "Amino acid transport across the plasma membrane, Staphylococcus aureus N315"
xref: Reactome:REACT_81602 "Amino acid transport across the plasma membrane, Oryza sativa"
xref: Reactome:REACT_81848 "Amino acid transport across the plasma membrane, Danio rerio"
xref: Reactome:REACT_83425 "Amino acid transport across the plasma membrane, Bos taurus"
xref: Reactome:REACT_90553 "Amino acid transport across the plasma membrane, Drosophila melanogaster"
xref: Reactome:REACT_95755 "Amino acid transport across the plasma membrane, Taeniopygia guttata"
xref: Reactome:REACT_96944 "Amino acid transport across the plasma membrane, Sus scrofa"
xref: Reactome:REACT_98408 "Amino acid transport across the plasma membrane, Xenopus tropicalis"
xref: Reactome:REACT_99072 "Amino acid transport across the plasma membrane, Canis familiaris"
is_a: GO:0046942 ! carboxylic acid transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0006867
name: asparagine transport
namespace: biological_process
def: "The directed movement of asparagine, alpha-aminosuccinamic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "L-asparagine transport" NARROW []
is_a: GO:0006812 ! cation transport
is_a: GO:0015804 ! neutral amino acid transport
is_a: GO:0042886 ! amide transport

[Term]
id: GO:0006868
name: glutamine transport
namespace: biological_process
alt_id: GO:0015815
def: "The directed movement of glutamine, 2-amino-4-carbamoylbutanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "L-glutamine transport" NARROW []
is_a: GO:0006812 ! cation transport
is_a: GO:0015804 ! neutral amino acid transport

[Term]
id: GO:0006869
name: lipid transport
namespace: biological_process
def: "The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
is_a: GO:0044765 ! single-organism transport
is_a: GO:0071702 ! organic substance transport
relationship: part_of GO:0010876 ! lipid localization

[Term]
id: GO:0006873
name: cellular ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of ions at the level of a cell." [GOC:mah]
subset: goslim_yeast
subset: gosubset_prok
is_a: GO:0050801 ! ion homeostasis
is_a: GO:0055082 ! cellular chemical homeostasis

[Term]
id: GO:0006874
name: cellular calcium ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell." [GOC:ceb, GOC:mah]
synonym: "regulation of calcium ion concentration" BROAD []
is_a: GO:0006875 ! cellular metal ion homeostasis
is_a: GO:0055074 ! calcium ion homeostasis
is_a: GO:0072503 ! cellular divalent inorganic cation homeostasis

[Term]
id: GO:0006875
name: cellular metal ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of metal ions at the level of a cell." [GOC:ai, GOC:mah]
subset: gosubset_prok
synonym: "cellular heavy metal ion homeostasis" NARROW []
is_a: GO:0030003 ! cellular cation homeostasis
is_a: GO:0055065 ! metal ion homeostasis

[Term]
id: GO:0006876
name: cellular cadmium ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of cadmium ions at the level of a cell." [GOC:ai, GOC:mah]
synonym: "cadmium homeostasis" BROAD []
is_a: GO:0046916 ! cellular transition metal ion homeostasis
is_a: GO:0055073 ! cadmium ion homeostasis
is_a: GO:0072503 ! cellular divalent inorganic cation homeostasis

[Term]
id: GO:0006877
name: cellular cobalt ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of cobalt ions at the level of a cell." [GOC:ai, GOC:mah]
synonym: "cobalt homeostasis" BROAD []
is_a: GO:0046916 ! cellular transition metal ion homeostasis
is_a: GO:0055068 ! cobalt ion homeostasis

[Term]
id: GO:0006878
name: cellular copper ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of copper ions at the level of a cell." [GOC:ai, GOC:mah]
subset: gosubset_prok
synonym: "copper homeostasis" BROAD []
is_a: GO:0046916 ! cellular transition metal ion homeostasis
is_a: GO:0055070 ! copper ion homeostasis

[Term]
id: GO:0006879
name: cellular iron ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell." [GOC:ai, GOC:mah]
subset: gosubset_prok
synonym: "iron homeostasis" BROAD []
xref: Reactome:REACT_101645 "Iron uptake and transport, Bos taurus"
xref: Reactome:REACT_102655 "Iron uptake and transport, Caenorhabditis elegans"
xref: Reactome:REACT_103816 "Iron uptake and transport, Canis familiaris"
xref: Reactome:REACT_105071 "Iron uptake and transport, Taeniopygia guttata"
xref: Reactome:REACT_108354 "Iron uptake and transport, Danio rerio"
xref: Reactome:REACT_110767 "Iron uptake and transport, Arabidopsis thaliana"
xref: Reactome:REACT_113782 "Iron uptake and transport, Staphylococcus aureus N315"
xref: Reactome:REACT_25060 "Iron uptake and transport, Homo sapiens"
xref: Reactome:REACT_32468 "Iron uptake and transport, Gallus gallus"
xref: Reactome:REACT_62492 "Iron uptake and transport, Rattus norvegicus"
xref: Reactome:REACT_80574 "Iron uptake and transport, Mus musculus"
xref: Reactome:REACT_82593 "Iron uptake and transport, Sus scrofa"
xref: Reactome:REACT_84782 "Iron uptake and transport, Oryza sativa"
xref: Reactome:REACT_92578 "Iron uptake and transport, Dictyostelium discoideum"
xref: Reactome:REACT_92720 "Iron uptake and transport, Drosophila melanogaster"
xref: Reactome:REACT_94016 "Iron uptake and transport, Xenopus tropicalis"
xref: Reactome:REACT_94713 "Iron uptake and transport, Plasmodium falciparum"
is_a: GO:0046916 ! cellular transition metal ion homeostasis
is_a: GO:0055072 ! iron ion homeostasis

[Term]
id: GO:0006880
name: intracellular sequestering of iron ion
namespace: biological_process
def: "The process of binding or confining iron ions in an intracellular area such that they are separated from other components of a biological system." [GOC:ai]
subset: gosubset_prok
synonym: "intracellular iron ion retention" EXACT []
synonym: "intracellular iron ion sequestering" EXACT []
synonym: "intracellular iron ion sequestration" EXACT []
synonym: "intracellular iron ion storage" EXACT []
synonym: "intracellular retention of iron ion" EXACT []
synonym: "intracellular sequestration of iron ion" EXACT []
synonym: "intracellular storage of iron ion" EXACT []
is_a: GO:0051651 ! maintenance of location in cell
is_a: GO:0097577 ! sequestering of iron ion
relationship: part_of GO:0006879 ! cellular iron ion homeostasis

[Term]
id: GO:0006881
name: extracellular sequestering of iron ion
namespace: biological_process
def: "The process of binding or confining iron ions in an extracellular area such that they are separated from other components of a biological system." [GOC:ai, GOC:cjm]
synonym: "extracellular iron ion retention" EXACT []
synonym: "extracellular iron ion sequestering" EXACT []
synonym: "extracellular iron ion sequestration" EXACT []
synonym: "extracellular iron ion storage" EXACT []
synonym: "extracellular retention of iron ion" EXACT []
synonym: "extracellular sequestration of iron ion" EXACT []
synonym: "extracellular storage of iron ion" EXACT []
is_a: GO:0097577 ! sequestering of iron ion
relationship: part_of GO:0006879 ! cellular iron ion homeostasis

[Term]
id: GO:0006882
name: cellular zinc ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of zinc ions at the level of a cell." [GOC:ai, GOC:mah]
synonym: "zinc homeostasis" BROAD []
is_a: GO:0046916 ! cellular transition metal ion homeostasis
is_a: GO:0055069 ! zinc ion homeostasis
is_a: GO:0072503 ! cellular divalent inorganic cation homeostasis

[Term]
id: GO:0006883
name: cellular sodium ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of sodium ions at the level of a cell." [GOC:ai, GOC:mah]
is_a: GO:0006875 ! cellular metal ion homeostasis
is_a: GO:0030004 ! cellular monovalent inorganic cation homeostasis
is_a: GO:0055078 ! sodium ion homeostasis

[Term]
id: GO:0006884
name: cell volume homeostasis
namespace: biological_process
def: "Any process involved in maintaining the steady state of a cell's volume. The cell's volume refers to the three-dimensional space occupied by a cell." [GOC:dph, GOC:go_curators, GOC:tb]
subset: gosubset_prok
synonym: "regulation of cell volume" EXACT [GOC:dph, GOC:tb]
is_a: GO:0008361 ! regulation of cell size
is_a: GO:0019725 ! cellular homeostasis

[Term]
id: GO:0006885
name: regulation of pH
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell." [GOC:dph, GOC:go_curators, GOC:tb]
subset: gosubset_prok
synonym: "hydrogen ion homeostasis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0055067 ! monovalent inorganic cation homeostasis

[Term]
id: GO:0006886
name: intracellular protein transport
namespace: biological_process
alt_id: GO:0032779
def: "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
subset: gosubset_prok
synonym: "copper-induced intracellular protein transport" RELATED [GOC:al]
is_a: GO:0015031 ! protein transport
is_a: GO:0046907 ! intracellular transport
relationship: occurs_in GO:0005622 ! intracellular
relationship: part_of GO:0034613 ! cellular protein localization

[Term]
id: GO:0006887
name: exocytosis
namespace: biological_process
alt_id: GO:0016194
alt_id: GO:0016195
def: "A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. Steps that prepare vesicles for fusion with the membrane (e.g. docking and priming) are included in this process. This is the process in which most molecules are secreted from eukaryotic cells." [GOC:mah, ISBN:0716731363]
subset: goslim_yeast
subset: gosubset_prok
synonym: "nonselective vesicle exocytosis" RELATED []
synonym: "vesicle exocytosis" EXACT []
xref: Wikipedia:Exocytosis
is_a: GO:0016192 ! vesicle-mediated transport
is_a: GO:0032940 ! secretion by cell

[Term]
id: GO:0006888
name: ER to Golgi vesicle-mediated transport
namespace: biological_process
alt_id: GO:0048221
def: "The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]
synonym: "anterograde (ER to Golgi) transport" EXACT []
synonym: "anterograde transport, endoplasmic reticulum to Golgi" EXACT []
synonym: "anterograde transport, ER to Golgi" EXACT []
synonym: "anterograde vesicle-mediated transport, endoplasmic reticulum to Golgi" EXACT []
synonym: "anterograde vesicle-mediated transport, ER to Golgi" EXACT []
synonym: "endoplasmic reticulum to Golgi transport" EXACT []
synonym: "endoplasmic reticulum to Golgi vesicle-mediated transport" EXACT []
synonym: "ER to Golgi transport" EXACT []
synonym: "rough endoplasmic reticulum to cis-Golgi transport" EXACT []
synonym: "rough endoplasmic reticulum to cis-Golgi vesicle-mediated transport" EXACT []
synonym: "rough ER to cis-Golgi transport" EXACT []
synonym: "rough ER to cis-Golgi vesicle-mediated transport" EXACT []
xref: Reactome:REACT_100295 "ER to Golgi Transport, Mus musculus"
xref: Reactome:REACT_101556 "ER to Golgi Transport, Bos taurus"
xref: Reactome:REACT_103849 "ER to Golgi Transport, Schizosaccharomyces pombe"
xref: Reactome:REACT_108191 "ER to Golgi Transport, Rattus norvegicus"
xref: Reactome:REACT_109717 "ER to Golgi Transport, Drosophila melanogaster"
xref: Reactome:REACT_110566 "ER to Golgi Transport, Saccharomyces cerevisiae"
xref: Reactome:REACT_11203 "ER to Golgi Transport, Homo sapiens"
xref: Reactome:REACT_28630 "ER to Golgi Transport, Oryza sativa"
xref: Reactome:REACT_32610 "ER to Golgi Transport, Arabidopsis thaliana"
xref: Reactome:REACT_33990 "ER to Golgi Transport, Canis familiaris"
xref: Reactome:REACT_77471 "ER to Golgi Transport, Plasmodium falciparum"
xref: Reactome:REACT_79334 "ER to Golgi Transport, Danio rerio"
xref: Reactome:REACT_85994 "ER to Golgi Transport, Dictyostelium discoideum"
xref: Reactome:REACT_86500 "ER to Golgi Transport, Xenopus tropicalis"
xref: Reactome:REACT_91022 "ER to Golgi Transport, Taeniopygia guttata"
xref: Reactome:REACT_91938 "ER to Golgi Transport, Sus scrofa"
xref: Reactome:REACT_92205 "ER to Golgi Transport, Gallus gallus"
is_a: GO:0048193 ! Golgi vesicle transport
relationship: occurs_in GO:0005737 ! cytoplasm

[Term]
id: GO:0006889
name: obsolete regulation of calcium in ER
namespace: biological_process
def: "OBSOLETE. Any process that modulates the concentration of calcium in the endoplasmic reticulum." [GOC:go_curators]
comment: This term was made obsolete because the term name is ambiguous and as a result, the term was incorrectly placed in the ontology (it was a descendant of 'protein transport').
synonym: "regulation of calcium in ER" EXACT []
is_obsolete: true
consider: GO:0005783
consider: GO:0006874

[Term]
id: GO:0006890
name: retrograde vesicle-mediated transport, Golgi to ER
namespace: biological_process
alt_id: GO:0048220
def: "The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG." [ISBN:0716731363, PMID:16510524]
synonym: "cis-Golgi to rough endoplasmic reticulum transport" EXACT []
synonym: "cis-Golgi to rough endoplasmic reticulum vesicle-mediated transport" EXACT []
synonym: "cis-Golgi to rough ER transport" EXACT []
synonym: "cis-Golgi to rough ER vesicle-mediated transport" EXACT []
synonym: "retrograde (Golgi to ER) transport" EXACT []
synonym: "retrograde transport, Golgi to endoplasmic reticulum" EXACT []
synonym: "retrograde transport, Golgi to ER" EXACT []
synonym: "retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum" RELATED []
xref: Reactome:REACT_101581 "Golgi to ER Retrograde Transport, Saccharomyces cerevisiae"
xref: Reactome:REACT_106254 "Golgi to ER Retrograde Transport, Caenorhabditis elegans"
xref: Reactome:REACT_107028 "Golgi to ER Retrograde Transport, Oryza sativa"
xref: Reactome:REACT_110794 "Golgi to ER Retrograde Transport, Taeniopygia guttata"
xref: Reactome:REACT_11208 "Golgi to ER Retrograde Transport, Homo sapiens"
xref: Reactome:REACT_33374 "Golgi to ER Retrograde Transport, Xenopus tropicalis"
xref: Reactome:REACT_78144 "Golgi to ER Retrograde Transport, Dictyostelium discoideum"
xref: Reactome:REACT_78992 "Golgi to ER Retrograde Transport, Mus musculus"
xref: Reactome:REACT_79320 "Golgi to ER Retrograde Transport, Sus scrofa"
xref: Reactome:REACT_84617 "Golgi to ER Retrograde Transport, Drosophila melanogaster"
xref: Reactome:REACT_84887 "Golgi to ER Retrograde Transport, Danio rerio"
xref: Reactome:REACT_86027 "Golgi to ER Retrograde Transport, Rattus norvegicus"
xref: Reactome:REACT_86772 "Golgi to ER Retrograde Transport, Schizosaccharomyces pombe"
xref: Reactome:REACT_87591 "Golgi to ER Retrograde Transport, Canis familiaris"
xref: Reactome:REACT_88478 "Golgi to ER Retrograde Transport, Plasmodium falciparum"
xref: Reactome:REACT_88525 "Golgi to ER Retrograde Transport, Arabidopsis thaliana"
xref: Reactome:REACT_92195 "Golgi to ER Retrograde Transport, Gallus gallus"
xref: Reactome:REACT_92336 "Golgi to ER Retrograde Transport, Bos taurus"
is_a: GO:0048193 ! Golgi vesicle transport

[Term]
id: GO:0006891
name: intra-Golgi vesicle-mediated transport
namespace: biological_process
def: "The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network)." [ISBN:0716731363]
synonym: "intra-Golgi transport" EXACT []
is_a: GO:0048193 ! Golgi vesicle transport

[Term]
id: GO:0006892
name: post-Golgi vesicle-mediated transport
namespace: biological_process
def: "The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles." [GOC:ai, GOC:mah]
synonym: "post-Golgi transport" EXACT []
xref: Reactome:REACT_101804 "trans-Golgi Network Vesicle Budding, Schizosaccharomyces pombe"
xref: Reactome:REACT_102043 "trans-Golgi Network Vesicle Budding, Mus musculus"
xref: Reactome:REACT_104522 "trans-Golgi Network Vesicle Budding, Sus scrofa"
xref: Reactome:REACT_105834 "trans-Golgi Network Vesicle Budding, Bos taurus"
xref: Reactome:REACT_109631 "trans-Golgi Network Vesicle Budding, Danio rerio"
xref: Reactome:REACT_11235 "trans-Golgi Network Vesicle Budding, Homo sapiens"
xref: Reactome:REACT_30453 "trans-Golgi Network Vesicle Budding, Drosophila melanogaster"
xref: Reactome:REACT_30783 "trans-Golgi Network Vesicle Budding, Taeniopygia guttata"
xref: Reactome:REACT_31900 "trans-Golgi Network Vesicle Budding, Oryza sativa"
xref: Reactome:REACT_31975 "trans-Golgi Network Vesicle Budding, Arabidopsis thaliana"
xref: Reactome:REACT_32509 "trans-Golgi Network Vesicle Budding, Xenopus tropicalis"
xref: Reactome:REACT_79028 "trans-Golgi Network Vesicle Budding, Canis familiaris"
xref: Reactome:REACT_87462 "trans-Golgi Network Vesicle Budding, Rattus norvegicus"
xref: Reactome:REACT_88705 "trans-Golgi Network Vesicle Budding, Dictyostelium discoideum"
xref: Reactome:REACT_90377 "trans-Golgi Network Vesicle Budding, Gallus gallus"
xref: Reactome:REACT_98073 "trans-Golgi Network Vesicle Budding, Caenorhabditis elegans"
is_a: GO:0048193 ! Golgi vesicle transport

[Term]
id: GO:0006893
name: Golgi to plasma membrane transport
namespace: biological_process
def: "The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis." [ISBN:0716731363]
synonym: "Golgi to plasma membrane vesicle-mediated transport" EXACT []
is_a: GO:0006892 ! post-Golgi vesicle-mediated transport

[Term]
id: GO:0006894
name: obsolete Golgi to secretory vesicle transport
namespace: biological_process
def: "OBSOLETE. The directed movement of proteins from the Golgi to one of two types of secretory vesicle. Continuously secreted proteins are sorted into transport vesicles that fuse with the plasma membrane, releasing their contents by exocytosis. Specialized secretory cells have a second secretory pathway in which soluble proteins and other substances are initially stored in secretory vesicles for later release." [ISBN:0716731363]
comment: This term was made obsolete because it mixes two processes that can be better captured in separate terms.
synonym: "Golgi to secretory vesicle transport" EXACT []
synonym: "Golgi to secretory vesicle transport, vesicle-mediated" EXACT []
is_obsolete: true
consider: GO:0055107
consider: GO:0055108

[Term]
id: GO:0006895
name: Golgi to endosome transport
namespace: biological_process
alt_id: GO:0048218
def: "The directed movement of substances from the Golgi to early sorting endosomes. Clathrin vesicles transport substances from the trans-Golgi to endosomes." [GOC:jl, ISBN:0716731363, PMID:10873832]
synonym: "Golgi to endosome vesicle-mediated transport" EXACT []
synonym: "TGN to endosome transport" EXACT []
synonym: "trans-Golgi to endosome transport" EXACT []
is_a: GO:0006896 ! Golgi to vacuole transport
is_a: GO:0016197 ! endosomal transport
is_a: GO:0016482 ! cytosolic transport
relationship: occurs_in GO:0005829 ! cytosol

[Term]
id: GO:0006896
name: Golgi to vacuole transport
namespace: biological_process
def: "The directed movement of substances from the Golgi to the vacuole." [GOC:ai]
synonym: "Golgi to vacuole vesicle-mediated transport" EXACT []
is_a: GO:0006892 ! post-Golgi vesicle-mediated transport
is_a: GO:0007034 ! vacuolar transport
relationship: occurs_in GO:0005622 ! intracellular

[Term]
id: GO:0006897
name: endocytosis
namespace: biological_process
alt_id: GO:0016193
alt_id: GO:0016196
def: "A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363]
subset: goslim_yeast
subset: gosubset_prok
synonym: "nonselective vesicle endocytosis" RELATED []
synonym: "plasma membrane invagination" EXACT []
synonym: "vesicle endocytosis" EXACT []
xref: Wikipedia:Endocytosis
is_a: GO:0016192 ! vesicle-mediated transport
relationship: has_part GO:0006900 ! membrane budding
relationship: has_part GO:0010324 ! membrane invagination

[Term]
id: GO:0006898
name: receptor-mediated endocytosis
namespace: biological_process
def: "An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles." [GOC:mah, ISBN:0716731363]
synonym: "receptor mediated endocytosis" EXACT []
xref: Reactome:REACT_100248 "LDL-mediated lipid transport, Gallus gallus"
xref: Reactome:REACT_100330 "chylomicron remnant:apoE:LDLR complex [coated vesicle membrane] => chylomicron remnant:apoE:LDLR complex [endosome membrane], Mus musculus"
xref: Reactome:REACT_103823 "LDLR [endosome membrane] => LDLR [plasma membrane], Sus scrofa"
xref: Reactome:REACT_103978 "LDLR:LDL complex => LDLR + LDL, Danio rerio"
xref: Reactome:REACT_104437 "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane], Sus scrofa"
xref: Reactome:REACT_105792 "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex, Danio rerio"
xref: Reactome:REACT_106851 "LDL-mediated lipid transport, Rattus norvegicus"
xref: Reactome:REACT_106981 "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane], Mus musculus"
xref: Reactome:REACT_107174 "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex, Sus scrofa"
xref: Reactome:REACT_107413 "LDL + LDLR => LDL:LDLR complex, Danio rerio"
xref: Reactome:REACT_107880 "chylomicron remnant:apoE:LDLR complex => chylomicron remnant:apoE + LDLR, Mus musculus"
xref: Reactome:REACT_109308 "LDLR:LDL complex => LDLR + LDL, Xenopus tropicalis"
xref: Reactome:REACT_110306 "LDL-mediated lipid transport, Canis familiaris"
xref: Reactome:REACT_110472 "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane], Bos taurus"
xref: Reactome:REACT_110785 "LDLR:LDL complex => LDLR + LDL, Bos taurus"
xref: Reactome:REACT_111177 "Movement of clathrin coated vesicles into early endosome, Homo sapiens"
xref: Reactome:REACT_112262 "LDLR [endosome membrane] => LDLR [plasma membrane], Taeniopygia guttata"
xref: Reactome:REACT_113143 "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane], Taeniopygia guttata"
xref: Reactome:REACT_113715 "LDLR [endosome membrane] => LDLR [plasma membrane], Drosophila melanogaster"
xref: Reactome:REACT_114061 "LDLR:LDL complex => LDLR + LDL, Taeniopygia guttata"
xref: Reactome:REACT_114157 "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex, Xenopus tropicalis"
xref: Reactome:REACT_114755 "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent), Taeniopygia guttata"
xref: Reactome:REACT_114861 "LDL + LDLR => LDL:LDLR complex, Taeniopygia guttata"
xref: Reactome:REACT_115278 "LDL-mediated lipid transport, Caenorhabditis elegans"
xref: Reactome:REACT_115471 "LDLR [endosome membrane] => LDLR [plasma membrane], Caenorhabditis elegans"
xref: Reactome:REACT_115520 "LDL-mediated lipid transport, Drosophila melanogaster"
xref: Reactome:REACT_28736 "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent), Canis familiaris"
xref: Reactome:REACT_29541 "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane], Canis familiaris"
xref: Reactome:REACT_30278 "LDLR [endosome membrane] => LDLR [plasma membrane], Bos taurus"
xref: Reactome:REACT_30568 "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent), Sus scrofa"
xref: Reactome:REACT_30705 "LDLR [endosome membrane] => LDLR [plasma membrane], Rattus norvegicus"
xref: Reactome:REACT_30731 "LDL + LDLR => LDL:LDLR complex, Sus scrofa"
xref: Reactome:REACT_31404 "LDLR:LDL complex => LDLR + LDL, Canis familiaris"
xref: Reactome:REACT_31638 "LDL-mediated lipid transport, Sus scrofa"
xref: Reactome:REACT_33230 "LDLR [endosome membrane] => LDLR [plasma membrane], Mus musculus"
xref: Reactome:REACT_33281 "chylomicron remnant:apoE:LDLR complex => chylomicron remnant:apoE + LDLR, Rattus norvegicus"
xref: Reactome:REACT_34027 "LDLR:LDL complex => LDLR + LDL, Sus scrofa"
xref: Reactome:REACT_50314 "LDL-mediated lipid transport, Mus musculus"
xref: Reactome:REACT_50874 "chylomicron remnant:apoE:LDLR complex [coated vesicle membrane] => chylomicron remnant:apoE:LDLR complex [endosome membrane], Rattus norvegicus"
xref: Reactome:REACT_6720 "chylomicron remnant:apoE:LDLR complex [coated vesicle membrane] => chylomicron remnant:apoE:LDLR complex [endosome membrane], Homo sapiens"
xref: Reactome:REACT_6775 "LDLR:LDL complex => LDLR + LDL, Homo sapiens"
xref: Reactome:REACT_6810 "LDLR [endosome membrane] => LDLR [plasma membrane], Homo sapiens"
xref: Reactome:REACT_6849 "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex, Homo sapiens"
xref: Reactome:REACT_6860 "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent), Homo sapiens"
xref: Reactome:REACT_6901 "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane], Homo sapiens"
xref: Reactome:REACT_6924 "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent), Homo sapiens"
xref: Reactome:REACT_6934 "LDL-mediated lipid transport, Homo sapiens"
xref: Reactome:REACT_6940 "LDL + LDLR => LDL:LDLR complex, Homo sapiens"
xref: Reactome:REACT_6951 "chylomicron remnant:apoE:LDLR complex => chylomicron remnant:apoE + LDLR, Homo sapiens"
xref: Reactome:REACT_77527 "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane], Xenopus tropicalis"
xref: Reactome:REACT_78454 "LDL + LDLR => LDL:LDLR complex, Mus musculus"
xref: Reactome:REACT_78761 "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex, Rattus norvegicus"
xref: Reactome:REACT_80639 "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane], Rattus norvegicus"
xref: Reactome:REACT_80964 "LDL-mediated lipid transport, Xenopus tropicalis"
xref: Reactome:REACT_81206 "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent), Xenopus tropicalis"
xref: Reactome:REACT_81516 "LDLR [endosome membrane] => LDLR [plasma membrane], Canis familiaris"
xref: Reactome:REACT_81850 "LDL + LDLR => LDL:LDLR complex, Rattus norvegicus"
xref: Reactome:REACT_82541 "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex, Bos taurus"
xref: Reactome:REACT_82595 "chylomicron remnant:apoE:LDLR complex => chylomicron remnant:apoE + LDLR, Canis familiaris"
xref: Reactome:REACT_83238 "chylomicron remnant:apoE:LDLR complex [coated vesicle membrane] => chylomicron remnant:apoE:LDLR complex [endosome membrane], Sus scrofa"
xref: Reactome:REACT_83320 "LDLR:LDL complex => LDLR + LDL, Mus musculus"
xref: Reactome:REACT_83479 "chylomicron remnant:apoE:LDLR complex => chylomicron remnant:apoE + LDLR, Xenopus tropicalis"
xref: Reactome:REACT_84153 "chylomicron remnant:apoE:LDLR complex => chylomicron remnant:apoE + LDLR, Sus scrofa"
xref: Reactome:REACT_84233 "LDLR [endosome membrane] => LDLR [plasma membrane], Danio rerio"
xref: Reactome:REACT_84451 "LDL + LDLR => LDL:LDLR complex, Canis familiaris"
xref: Reactome:REACT_84602 "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent), Danio rerio"
xref: Reactome:REACT_84963 "chylomicron remnant:apoE:LDLR complex [coated vesicle membrane] => chylomicron remnant:apoE:LDLR complex [endosome membrane], Bos taurus"
xref: Reactome:REACT_84978 "LDLR [endosome membrane] => LDLR [plasma membrane], Xenopus tropicalis"
xref: Reactome:REACT_84983 "LDL + LDLR => LDL:LDLR complex, Bos taurus"
xref: Reactome:REACT_85895 "LDL + LDLR => LDL:LDLR complex, Xenopus tropicalis"
xref: Reactome:REACT_86311 "chylomicron remnant:apoE:LDLR complex [coated vesicle membrane] => chylomicron remnant:apoE:LDLR complex [endosome membrane], Danio rerio"
xref: Reactome:REACT_87254 "chylomicron remnant:apoE:LDLR complex [coated vesicle membrane] => chylomicron remnant:apoE:LDLR complex [endosome membrane], Xenopus tropicalis"
xref: Reactome:REACT_87301 "chylomicron remnant:apoE:LDLR complex => chylomicron remnant:apoE + LDLR, Bos taurus"
xref: Reactome:REACT_90065 "chylomicron remnant:apoE:LDLR complex => chylomicron remnant:apoE + LDLR, Danio rerio"
xref: Reactome:REACT_90294 "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent), Rattus norvegicus"
xref: Reactome:REACT_90795 "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex, Canis familiaris"
xref: Reactome:REACT_91303 "LDLR:LDL complex => LDLR + LDL, Rattus norvegicus"
xref: Reactome:REACT_91595 "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent), Mus musculus"
xref: Reactome:REACT_93284 "LDL-mediated lipid transport, Bos taurus"
xref: Reactome:REACT_93519 "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex, Mus musculus"
xref: Reactome:REACT_94912 "LDL-mediated lipid transport, Danio rerio"
xref: Reactome:REACT_95536 "LDL-mediated lipid transport, Taeniopygia guttata"
xref: Reactome:REACT_96679 "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane], Danio rerio"
xref: Reactome:REACT_98265 "chylomicron remnant:apoE:LDLR complex [coated vesicle membrane] => chylomicron remnant:apoE:LDLR complex [endosome membrane], Canis familiaris"
xref: Reactome:REACT_99018 "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent), Bos taurus"
xref: Wikipedia:Receptor-mediated_endocytosis
is_a: GO:0006897 ! endocytosis

[Term]
id: GO:0006900
name: membrane budding
namespace: biological_process
alt_id: GO:0006902
def: "The evagination of a membrane, resulting in formation of a vesicle." [GOC:jid, GOC:tb]
synonym: "membrane evagination" EXACT []
synonym: "nonselective vesicle assembly" RELATED []
synonym: "vesicle biosynthesis" EXACT []
synonym: "vesicle budding" RELATED []
synonym: "vesicle formation" EXACT []
is_a: GO:0016050 ! vesicle organization
is_a: GO:0061024 ! membrane organization
relationship: part_of GO:0016192 ! vesicle-mediated transport

[Term]
id: GO:0006901
name: vesicle coating
namespace: biological_process
def: "A protein coat is added to the vesicle to form the proper shape of the vesicle and to target the vesicle for transport to its destination." [GOC:jid]
synonym: "vesicle coat assembly" BROAD []
is_a: GO:0016050 ! vesicle organization
relationship: part_of GO:0006900 ! membrane budding

[Term]
id: GO:0006903
name: vesicle targeting
namespace: biological_process
def: "The process in which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo." [GOC:mah, PMID:17335816]
is_a: GO:0044763 ! single-organism cellular process
relationship: part_of GO:0016192 ! vesicle-mediated transport
relationship: part_of GO:0051650 ! establishment of vesicle localization

[Term]
id: GO:0006904
name: vesicle docking involved in exocytosis
namespace: biological_process
def: "The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis." [GOC:jid]
subset: gosubset_prok
synonym: "vesicle docking during exocytosis" RELATED [GOC:dph, GOC:tb]
is_a: GO:0048278 ! vesicle docking
intersection_of: GO:0048278 ! vesicle docking
intersection_of: part_of GO:0006887 ! exocytosis
relationship: part_of GO:0006887 ! exocytosis

[Term]
id: GO:0006905
name: obsolete vesicle transport
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "vesicle transport" EXACT []
is_obsolete: true
consider: GO:0016192

[Term]
id: GO:0006906
name: vesicle fusion
namespace: biological_process
def: "Fusion of the membrane of a transport vesicle with its target membrane." [GOC:jid]
is_a: GO:0016050 ! vesicle organization
is_a: GO:0090174 ! organelle membrane fusion
relationship: part_of GO:0016192 ! vesicle-mediated transport

[Term]
id: GO:0006907
name: pinocytosis
namespace: biological_process
alt_id: GO:0006908
def: "An endocytosis process that results in the uptake of liquid material by cells from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, called pinosomes, formed by invagination of the plasma membrane." [ISBN:0198506732]
synonym: "clathrin-independent pinocytosis" BROAD []
synonym: "fluid-phase endocytosis" EXACT []
xref: Wikipedia:Pinocytosis
is_a: GO:0006897 ! endocytosis

[Term]
id: GO:0006909
name: phagocytosis
namespace: biological_process
def: "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
xref: Wikipedia:Phagocytosis
is_a: GO:0006897 ! endocytosis
is_a: GO:0044765 ! single-organism transport

[Term]
id: GO:0006910
name: phagocytosis, recognition
namespace: biological_process
def: "The initial step in phagocytosis involving adhesion to bacteria, immune complexes and other particulate matter, or an apoptotic cell and based on recognition of factors such as bacterial cell wall components, opsonins like complement and antibody or protein receptors and lipids like phosphatidyl serine, and leading to intracellular signaling in the phagocytosing cell." [GOC:curators, ISBN:0781735149]
comment: Note that cell surface molecules involved in the direct binding of bacteria may be also annotated to the molecular function term 'bacterial cell surface binding ; GO:0051635'. Note that cell surface molecules involved in the direct binding to opsonins such as complement components or antibodies may be also annotated to the term 'opsonin binding ; GO:0001846'.
synonym: "recognition of phagocytosed substance by phagocytic cell" EXACT []
is_a: GO:0008037 ! cell recognition
intersection_of: GO:0008037 ! cell recognition
intersection_of: part_of GO:0006909 ! phagocytosis
relationship: part_of GO:0006909 ! phagocytosis

[Term]
id: GO:0006911
name: phagocytosis, engulfment
namespace: biological_process
def: "The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis." [GOC:curators, ISBN:0781735149]
synonym: "phagosome biosynthesis" RELATED []
synonym: "phagosome formation" RELATED []
is_a: GO:0010324 ! membrane invagination
intersection_of: GO:0010324 ! membrane invagination
intersection_of: part_of GO:0006909 ! phagocytosis
relationship: part_of GO:0006909 ! phagocytosis

[Term]
id: GO:0006912
name: obsolete phagosome formation
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:hjd]
comment: This term was made obsolete because of the ambiguity in its meaning.
synonym: "phagosome formation" EXACT []
is_obsolete: true
consider: GO:0001845
consider: GO:0006911

[Term]
id: GO:0006913
name: nucleocytoplasmic transport
namespace: biological_process
alt_id: GO:0000063
def: "The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]
comment: Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane, and is not traversed.
subset: goslim_chembl
subset: goslim_generic
subset: goslim_pombe
synonym: "nucleocytoplasmic shuttling" NARROW []
is_a: GO:0051169 ! nuclear transport
relationship: occurs_in GO:0005622 ! intracellular

[Term]
id: GO:0006914
name: autophagy
namespace: biological_process
alt_id: GO:0016238
def: "The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:9412464]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_pir
subset: goslim_pombe
xref: Wikipedia:Autophagy_(cellular)
is_a: GO:0009987 ! cellular process
relationship: has_part GO:0044248 ! cellular catabolic process

[Term]
id: GO:0006915
name: apoptotic process
namespace: biological_process
alt_id: GO:0006917
alt_id: GO:0008632
def: "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
synonym: "activation of apoptosis" NARROW []
synonym: "apoptosis" NARROW []
synonym: "apoptosis activator activity" RELATED []
synonym: "apoptosis signaling" NARROW []
synonym: "apoptotic cell death" EXACT [GOC:sl]
synonym: "apoptotic program" NARROW [GOC:add]
synonym: "apoptotic programmed cell death" EXACT []
synonym: "caspase-dependent programmed cell death" RELATED []
synonym: "cell suicide" BROAD []
synonym: "cellular suicide" BROAD []
synonym: "commitment to apoptosis" RELATED []
synonym: "induction of apoptosis" RELATED []
synonym: "induction of apoptosis by p53" RELATED []
synonym: "programmed cell death by apoptosis" EXACT []
synonym: "signaling (initiator) caspase activity" RELATED []
synonym: "type I programmed cell death" NARROW []
xref: Reactome:REACT_100045 "Apoptosis, Drosophila melanogaster"
xref: Reactome:REACT_100962 "Apoptosis, Mus musculus"
xref: Reactome:REACT_101249 "NRIF signals cell death from the nucleus, Danio rerio"
xref: Reactome:REACT_104187 "NRAGE signals death through JNK, Taeniopygia guttata"
xref: Reactome:REACT_105149 "NADE modulates death signalling, Rattus norvegicus"
xref: Reactome:REACT_106405 "NRAGE signals death through JNK, Xenopus tropicalis"
xref: Reactome:REACT_106672 "NADE modulates death signalling, Sus scrofa"
xref: Reactome:REACT_107264 "NRIF signals cell death from the nucleus, Xenopus tropicalis"
xref: Reactome:REACT_108651 "NRAGE signals death through JNK, Mus musculus"
xref: Reactome:REACT_109165 "NRAGE signals death through JNK, Arabidopsis thaliana"
xref: Reactome:REACT_110081 "NRAGE signals death through JNK, Schizosaccharomyces pombe"
xref: Reactome:REACT_111964 "NRAGE signals death through JNK, Dictyostelium discoideum"
xref: Reactome:REACT_13526 "NADE modulates death signalling, Homo sapiens"
xref: Reactome:REACT_13638 "NRAGE signals death through JNK, Homo sapiens"
xref: Reactome:REACT_13643 "NRIF signals cell death from the nucleus, Homo sapiens"
xref: Reactome:REACT_28087 "Apoptosis, Saccharomyces cerevisiae"
xref: Reactome:REACT_28795 "Apoptosis, Oryza sativa"
xref: Reactome:REACT_28816 "Apoptosis, Danio rerio"
xref: Reactome:REACT_30266 "Apoptosis, Arabidopsis thaliana"
xref: Reactome:REACT_30361 "Apoptosis, Canis familiaris"
xref: Reactome:REACT_30371 "NRAGE signals death through JNK, Saccharomyces cerevisiae"
xref: Reactome:REACT_30548 "NRAGE signals death through JNK, Caenorhabditis elegans"
xref: Reactome:REACT_30763 "NRAGE signals death through JNK, Oryza sativa"
xref: Reactome:REACT_31349 "NRAGE signals death through JNK, Canis familiaris"
xref: Reactome:REACT_34139 "NRAGE signals death through JNK, Gallus gallus"
xref: Reactome:REACT_578 "Apoptosis, Homo sapiens"
xref: Reactome:REACT_77132 "NRAGE signals death through JNK, Drosophila melanogaster"
xref: Reactome:REACT_77313 "NADE modulates death signalling, Bos taurus"
xref: Reactome:REACT_77415 "NRIF signals cell death from the nucleus, Canis familiaris"
xref: Reactome:REACT_78287 "Apoptosis, Gallus gallus"
xref: Reactome:REACT_78802 "NADE modulates death signalling, Canis familiaris"
xref: Reactome:REACT_79809 "Apoptosis, Schizosaccharomyces pombe"
xref: Reactome:REACT_82724 "Apoptosis, Taeniopygia guttata"
xref: Reactome:REACT_83328 "Apoptosis, Sus scrofa"
xref: Reactome:REACT_85877 "NRAGE signals death through JNK, Rattus norvegicus"
xref: Reactome:REACT_86749 "Apoptosis, Rattus norvegicus"
xref: Reactome:REACT_86873 "NRIF signals cell death from the nucleus, Gallus gallus"
xref: Reactome:REACT_87570 "NRIF signals cell death from the nucleus, Rattus norvegicus"
xref: Reactome:REACT_88740 "NRIF signals cell death from the nucleus, Sus scrofa"
xref: Reactome:REACT_88784 "NRIF signals cell death from the nucleus, Mus musculus"
xref: Reactome:REACT_89196 "Apoptosis, Dictyostelium discoideum"
xref: Reactome:REACT_90267 "NRIF signals cell death from the nucleus, Taeniopygia guttata"
xref: Reactome:REACT_91011 "Apoptosis, Caenorhabditis elegans"
xref: Reactome:REACT_91243 "NADE modulates death signalling, Mus musculus"
xref: Reactome:REACT_93937 "Apoptosis, Bos taurus"
xref: Reactome:REACT_94099 "NRAGE signals death through JNK, Danio rerio"
xref: Reactome:REACT_95069 "Apoptosis, Xenopus tropicalis"
xref: Reactome:REACT_95675 "Apoptosis, Plasmodium falciparum"
xref: Reactome:REACT_97627 "NRIF signals cell death from the nucleus, Bos taurus"
xref: Reactome:REACT_99784 "NRAGE signals death through JNK, Bos taurus"
xref: Reactome:REACT_99799 "NRAGE signals death through JNK, Sus scrofa"
xref: Wikipedia:Apoptosis
is_a: GO:0012501 ! programmed cell death

[Term]
id: GO:0006918
name: obsolete induction of apoptosis by p53
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because more accurate terms were created.
synonym: "induction of apoptosis by p53" EXACT []
is_obsolete: true
consider: GO:0006915

[Term]
id: GO:0006919
name: activation of cysteine-type endopeptidase activity involved in apoptotic process
namespace: biological_process
def: "Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process." [GOC:al, GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, PMID:18328827, Wikipedia:Caspase]
comment: This term should be used when the annotation refers to a process that occurs in a context of apoptotic cell death. To annotate gene products involved in activation of cysteine-type endopeptidases in other cellular process (e.g., cell cycle arrest) that do not necessarily develop into an apoptotic process, please use the more general parent term GO:0097202. Examples of 'activation of cysteine-type endopeptidase activity involved in apoptotic process' are cytochrome c and Apaf1. When cytochrome c is released from mitochondria and forms a complex with Apaf1, they form a scaffolding platform in which the pro-caspase 9 is bound (the 'apoptosome'). The caspase is then cleaved and activated. Cytochrome c and Apaf1 are therefore involved in the conversion of the zymogen procaspase 9 to the active form of the caspase.
synonym: "activation of caspase activity" NARROW []
synonym: "activation of metacaspase activity" NARROW []
synonym: "caspase activation" EXACT [GOC:dph, GOC:tb]
xref: Reactome:REACT_103096 "Activation of Pro-Caspase 8, Taeniopygia guttata"
xref: Reactome:REACT_108966 "Activation of Pro-Caspase 8, Danio rerio"
xref: Reactome:REACT_109094 "Activation of Pro-Caspase 8, Canis familiaris"
xref: Reactome:REACT_110733 "Activation of Pro-Caspase 8, Mus musculus"
xref: Reactome:REACT_832 "Activation of Pro-Caspase 8, Homo sapiens"
xref: Reactome:REACT_93871 "Activation of Pro-Caspase 8, Gallus gallus"
xref: Reactome:REACT_96857 "Activation of Pro-Caspase 8, Rattus norvegicus"
xref: Reactome:REACT_96984 "Activation of Pro-Caspase 8, Sus scrofa"
xref: Reactome:REACT_99084 "Activation of Pro-Caspase 8, Bos taurus"
is_a: GO:0043280 ! positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
is_a: GO:0097202 ! activation of cysteine-type endopeptidase activity
intersection_of: GO:0097202 ! activation of cysteine-type endopeptidase activity
intersection_of: part_of GO:0006915 ! apoptotic process
relationship: part_of GO:0006915 ! apoptotic process

[Term]
id: GO:0006920
name: obsolete commitment to apoptosis
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because more accurate terms were created.
synonym: "commitment to apoptosis" EXACT []
is_obsolete: true
consider: GO:0006915

[Term]
id: GO:0006921
name: cellular component disassembly involved in execution phase of apoptosis
namespace: biological_process
def: "The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb]
synonym: "cellular component disassembly involved in apoptosis" NARROW []
synonym: "cellular component disassembly involved in apoptotic process" BROAD []
synonym: "disassembly of cell structures" BROAD []
xref: Reactome:REACT_100800 "Apoptotic execution phase, Danio rerio"
xref: Reactome:REACT_108463 "Apoptotic execution phase, Taeniopygia guttata"
xref: Reactome:REACT_29660 "Apoptotic execution phase, Oryza sativa"
xref: Reactome:REACT_77151 "Apoptotic execution phase, Sus scrofa"
xref: Reactome:REACT_78666 "Apoptotic execution phase, Saccharomyces cerevisiae"
xref: Reactome:REACT_79472 "Apoptotic execution phase, Schizosaccharomyces pombe"
xref: Reactome:REACT_79859 "Apoptotic execution phase, Rattus norvegicus"
xref: Reactome:REACT_80493 "Apoptotic execution phase, Dictyostelium discoideum"
xref: Reactome:REACT_81021 "Apoptotic execution phase, Drosophila melanogaster"
xref: Reactome:REACT_81052 "Apoptotic execution phase, Canis familiaris"
xref: Reactome:REACT_84120 "Apoptotic execution phase, Xenopus tropicalis"
xref: Reactome:REACT_89424 "Apoptotic execution phase, Arabidopsis thaliana"
xref: Reactome:REACT_90988 "Apoptotic execution phase, Plasmodium falciparum"
xref: Reactome:REACT_92689 "Apoptotic execution phase, Caenorhabditis elegans"
xref: Reactome:REACT_93576 "Apoptotic execution phase, Gallus gallus"
xref: Reactome:REACT_94230 "Apoptotic execution phase, Bos taurus"
xref: Reactome:REACT_97703 "Apoptotic execution phase, Mus musculus"
xref: Reactome:REACT_995 "Apoptotic execution phase, Homo sapiens"
is_a: GO:0022411 ! cellular component disassembly
intersection_of: GO:0022411 ! cellular component disassembly
intersection_of: part_of GO:0097194 ! execution phase of apoptosis
relationship: part_of GO:0097194 ! execution phase of apoptosis

[Term]
id: GO:0006922
name: obsolete cleavage of lamin involved in execution phase of apoptosis
namespace: biological_process
def: "OBSOLETE. The proteolytic degradation of lamins during apoptosis, leading to the irreversible breakdown of the nuclear lamina." [GOC:mah, GOC:mtg_apoptosis, ISBN:0815332181]
comment: This term was obsoleted because it refers to targets of effector proteins (caspases); the 'cleavage' process referred to in the term name is in fact the same molecular function represented by GO:0097200 'cysteine-type endopeptidase activity involved in execution phase of apoptosis'.
synonym: "cleavage of lamin" BROAD []
synonym: "cleavage of lamin involved in execution phase of apoptosis" EXACT []
is_obsolete: true
consider: GO:0097200

[Term]
id: GO:0006923
name: obsolete cleavage of cytoskeletal proteins involved in execution phase of apoptosis
namespace: biological_process
def: "OBSOLETE. The proteolytic degradation of cytoskeletal proteins that contributes to apoptosis, leading to the collapse of cytoskeletal structures." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, ISBN:0815332181]
comment: This term was obsoleted because it refers to targets of effector proteins (caspases); the 'cleavage' process referred to in the term name is in fact the same molecular function represented by GO:0097200 'cysteine-type endopeptidase activity involved in execution phase of apoptosis'.
synonym: "apoptotic cleavage of cytoskeletal proteins" EXACT []
synonym: "cleavage of cytoskeletal proteins involved in apoptosis" BROAD []
synonym: "cleavage of cytoskeletal proteins involved in execution phase of apoptosis" EXACT []
is_obsolete: true
consider: GO:0097200

[Term]
id: GO:0006924
name: activation-induced cell death of T cells
namespace: biological_process
def: "A T cell apoptotic process that occurs towards the end of the expansion phase following the initial activation of mature T cells by antigen and is triggered by T cell receptor stimulation and signals transmitted via various surface-expressed members of the TNF receptor family such as Fas ligand, Fas, and TNF and the p55 and p75 TNF receptors." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196, PMID:12414721, PMID:12752672]
synonym: "activated T cell apoptosis" BROAD [GOC:add]
synonym: "activation-induced cell death of T lymphocytes" EXACT [GOC:add]
synonym: "activation-induced cell death of T-cells" EXACT [GOC:add]
synonym: "activation-induced cell death of T-lymphocytes" EXACT [GOC:add]
synonym: "AICD" BROAD [GOC:add]
synonym: "antigen-driven apoptosis" BROAD [GOC:add]
is_a: GO:0070231 ! T cell apoptotic process
relationship: part_of GO:0043029 ! T cell homeostasis

[Term]
id: GO:0006925
name: inflammatory cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in an inflammatory cell, any cell participating in the inflammatory response to a foreign substance e.g. neutrophil, macrophage." [GOC:jl, GOC:mtg_apoptosis, http://www.mercksource.com/]
synonym: "apoptosis of inflammatory cells" EXACT []
synonym: "inflammatory cell apoptosis" NARROW []
synonym: "inflammatory cell programmed cell death by apoptosis" EXACT []
synonym: "killing of inflammatory cells" EXACT []
synonym: "programmed cell death of inflammatory cells by apoptosis" EXACT []
synonym: "programmed cell death, inflammatory cells" EXACT []
is_a: GO:0006915 ! apoptotic process

[Term]
id: GO:0006926
name: obsolete virus-infected cell apoptotic process
namespace: biological_process
def: "OBSOLETE. Any apoptotic process in a cell infected with a virus." [GOC:jl, GOC:mtg_apoptosis]
comment: This term was made obsolete because the meaning of the term is ambiguous, as it's possibly conflating at least two scenarios: 1) the organism apoptoses its own cell because it detects it is infected with a virus; 2) the virus induces apoptosis so the cell is lysed and the virus disseminated. Please consider using viral process terms to annotate viral proteins. As for the cellular apoptotic process, this likely occurs via the same mechanisms described by existing apoptotic process terms, so please consider using those to annotate cellular proteins.
synonym: "apoptosis of virus-infected cells" EXACT []
synonym: "killing virus-infected cells" EXACT []
synonym: "programmed cell death of virus-infected cells by apoptosis" EXACT []
synonym: "programmed cell death, virus-infected cells" EXACT []
synonym: "virus-infected cell apoptosis" NARROW []
synonym: "virus-infected cell apoptotic process" EXACT []
synonym: "virus-infected cell programmed cell death by apoptosis" EXACT []
is_obsolete: true

[Term]
id: GO:0006927
name: transformed cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a transformed cell, a cell that has undergone changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm." [GOC:jl, GOC:mtg_apoptosis, MeSH:C04.697.152]
synonym: "apoptosis of transformed cells" EXACT []
synonym: "killing transformed cells" EXACT []
synonym: "programmed cell death of transformed cells by apoptosis" EXACT []
synonym: "programmed cell death, transformed cells" EXACT []
synonym: "transformed cell apoptosis" NARROW []
synonym: "transformed cell programmed cell death by apoptosis" EXACT []
is_a: GO:0006915 ! apoptotic process

[Term]
id: GO:0006928
name: movement of cell or subcellular component
namespace: biological_process
def: "The directed, self-propelled movement of a cell or subcellular component without the involvement of an external agent such as a transporter or a pore." [GOC:dgh, GOC:dph, GOC:jl, GOC:mlg]
comment: Note that in GO cellular components include whole cells (cell is_a cellular component).
subset: goantislim_grouping
subset: gocheck_do_not_annotate
subset: goslim_pir
subset: gosubset_prok
synonym: "cell movement" RELATED []
synonym: "cellular component motion" EXACT [GOC:dph, GOC:jl]
synonym: "cellular component movement" EXACT []
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0006929
name: substrate-dependent cell migration
namespace: biological_process
def: "The orderly movement of a cell from one site to another along a substrate such as the extracellular matrix; the migrating cell forms a protrusion that attaches to the substrate." [ISBN:0815316194, PMID:11944043, PMID:14657486]
synonym: "substrate-bound cell migration" EXACT [GOC:curators]
is_a: GO:0016477 ! cell migration

[Term]
id: GO:0006930
name: substrate-dependent cell migration, cell extension
namespace: biological_process
def: "The formation of a cell surface protrusion, such as a lamellipodium or filopodium, at the leading edge of a migrating cell." [ISBN:0815316194, PMID:11944043, PMID:14657486]
synonym: "substrate-bound cell migration, cell extension" EXACT [GOC:curators]
is_a: GO:0030031 ! cell projection assembly
relationship: part_of GO:0006929 ! substrate-dependent cell migration

[Term]
id: GO:0006931
name: substrate-dependent cell migration, cell attachment to substrate
namespace: biological_process
def: "The formation of adhesions that stabilize protrusions at the leading edge of a migrating cell; involves integrin activation, clustering, and the recruitment of structural and signaling components to nascent adhesions." [ISBN:0815316194, PMID:11944043, PMID:14657486]
synonym: "substrate-bound cell migration, cell attachment to substrate" EXACT [GOC:curators]
is_a: GO:0031589 ! cell-substrate adhesion
relationship: part_of GO:0006929 ! substrate-dependent cell migration

[Term]
id: GO:0006932
name: substrate-dependent cell migration, cell contraction
namespace: biological_process
def: "The translocation of the cell body forward during cell migration, mediated by tractional force on its substrate and tension in the cortical cytoskeleton. Adhesions transmit propulsive forces and serve as traction points over which the cell moves." [ISBN:0815316194, PMID:11944043, PMID:14657486]
synonym: "substrate-bound cell migration, cell contraction" EXACT [GOC:curators]
is_a: GO:0060327 ! cytoplasmic actin-based contraction involved in cell motility
relationship: part_of GO:0001667 ! ameboidal-type cell migration
relationship: part_of GO:0006929 ! substrate-dependent cell migration

[Term]
id: GO:0006933
name: negative regulation of cell adhesion involved in substrate-bound cell migration
namespace: biological_process
def: "The disassembly of adhesions at the front and rear of a migrating cell. At the leading edge, adhesion disassembly accompanies the formation of new protrusions; at the cell rear, it promotes tail retraction." [GOC:dph, GOC:tb, ISBN:0815316194, PMID:11944043, PMID:14657486]
synonym: "substrate-bound cell migration, cell release from substrate" EXACT [GOC:dph, GOC:tb]
is_a: GO:0007162 ! negative regulation of cell adhesion
intersection_of: GO:0007162 ! negative regulation of cell adhesion
intersection_of: part_of GO:0006929 ! substrate-dependent cell migration
relationship: part_of GO:0006929 ! substrate-dependent cell migration

[Term]
id: GO:0006934
name: substrate-bound cell migration, adhesion receptor recycling
namespace: biological_process
def: "The directed movement of accumulated adhesion components such as integrins from the rear of a migrating cell toward the cell front, where they are available to form new protrusions and adhesions." [PMID:11944043]
is_a: GO:0001881 ! receptor recycling
relationship: part_of GO:0006933 ! negative regulation of cell adhesion involved in substrate-bound cell migration

[Term]
id: GO:0006935
name: chemotaxis
namespace: biological_process
def: "The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [ISBN:0198506732]
subset: goslim_metagenomics
subset: gosubset_prok
synonym: "taxis in response to chemical stimulus" EXACT []
xref: Wikipedia:Chemotaxis
is_a: GO:0042330 ! taxis
relationship: part_of GO:0042221 ! response to chemical

[Term]
id: GO:0006936
name: muscle contraction
namespace: biological_process
def: "A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis." [GOC:ef, GOC:mtg_muscle, ISBN:0198506732]
subset: goslim_pir
xref: Reactome:REACT_100109 "Smooth Muscle Contraction, Canis familiaris"
xref: Reactome:REACT_102067 "Smooth Muscle Contraction, Taeniopygia guttata"
xref: Reactome:REACT_20558 "Smooth Muscle Contraction, Homo sapiens"
xref: Reactome:REACT_29015 "Smooth Muscle Contraction, Danio rerio"
xref: Reactome:REACT_77478 "Smooth Muscle Contraction, Xenopus tropicalis"
xref: Reactome:REACT_81255 "Smooth Muscle Contraction, Mus musculus"
xref: Reactome:REACT_83607 "Smooth Muscle Contraction, Bos taurus"
xref: Reactome:REACT_85440 "Smooth Muscle Contraction, Gallus gallus"
xref: Reactome:REACT_87764 "Smooth Muscle Contraction, Sus scrofa"
xref: Reactome:REACT_88232 "Smooth Muscle Contraction, Rattus norvegicus"
xref: Reactome:REACT_92442 "Smooth Muscle Contraction, Dictyostelium discoideum"
xref: Wikipedia:Muscle_contraction
is_a: GO:0003012 ! muscle system process

[Term]
id: GO:0006937
name: regulation of muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of muscle contraction." [GOC:go_curators]
is_a: GO:0090257 ! regulation of muscle system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006936 ! muscle contraction
relationship: regulates GO:0006936 ! muscle contraction

[Term]
id: GO:0006939
name: smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length." [GOC:ef, GOC:jl, GOC:mtg_muscle, ISBN:0198506732]
synonym: "visceral muscle contraction" EXACT []
is_a: GO:0006936 ! muscle contraction

[Term]
id: GO:0006940
name: regulation of smooth muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of smooth muscle contraction." [GOC:go_curators]
is_a: GO:0006937 ! regulation of muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006939 ! smooth muscle contraction
relationship: regulates GO:0006939 ! smooth muscle contraction

[Term]
id: GO:0006941
name: striated muscle contraction
namespace: biological_process
def: "A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope." [GOC:jl, GOC:mtg_muscle, ISBN:0198506732]
synonym: "sarcomeric muscle contraction" EXACT []
is_a: GO:0006936 ! muscle contraction

[Term]
id: GO:0006942
name: regulation of striated muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of striated muscle contraction." [GOC:go_curators]
is_a: GO:0006937 ! regulation of muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006941 ! striated muscle contraction
relationship: regulates GO:0006941 ! striated muscle contraction

[Term]
id: GO:0006943
name: obsolete chemi-mechanical coupling
namespace: biological_process
def: "OBSOLETE. The conversion of chemical energy into mechanical work (as in the contraction of a muscle)." [GOC:jid, http://www.m-w.com]
comment: This term was made obsolete because its meaning is vague, and it does not fit with other terms in GO.
synonym: "chemi-mechanical coupling" EXACT []
synonym: "mechanochemical coupling" EXACT []
is_obsolete: true
consider: GO:0009612
consider: GO:0050954

[Term]
id: GO:0006945
name: obsolete nuclear fusion during karyogamy
namespace: biological_process
def: "OBSOLETE. The fusion of two haploid nuclei to form a single diploid nucleus, as seen in the yeast mating process." [PMID:9442101]
comment: This term was made obsolete because it is redundant outside the context of Saccharomyces biology.
synonym: "nuclear fusion during karyogamy" EXACT []
is_obsolete: true
consider: GO:0000741

[Term]
id: GO:0006948
name: induction by virus of host cell-cell fusion
namespace: biological_process
def: "The process of syncytia-forming cell-cell fusion, caused by a virus." [ISBN:0781718325]
comment: Where syncytium formation results in the spread of virus in the host, also consider annotating to the term 'spread of virus in multicellular host ; GO:0046739'.
synonym: "induction by virus of cell-cell fusion in host" EXACT []
synonym: "viral-induced cell-cell fusion" EXACT []
synonym: "viral-induced host cell-cell fusion" EXACT []
synonym: "viral-induced membrane fusion" NARROW []
is_a: GO:0019054 ! modulation by virus of host process

[Term]
id: GO:0006949
name: syncytium formation
namespace: biological_process
def: "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane. Syncytia are normally derived from single cells that fuse or fail to complete cell division." [ISBN:0198506732]
subset: goslim_pir
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis

[Term]
id: GO:0006950
name: response to stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_plant
subset: gosubset_prok
synonym: "response to abiotic stress" RELATED []
synonym: "response to biotic stress" RELATED []
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0006952
name: defense response
namespace: biological_process
alt_id: GO:0002217
alt_id: GO:0042829
def: "Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators]
subset: gosubset_prok
synonym: "antimicrobial peptide activity" RELATED []
synonym: "defence response" EXACT []
synonym: "defense/immunity protein activity" RELATED []
synonym: "physiological defense response" EXACT []
is_a: GO:0006950 ! response to stress

[Term]
id: GO:0006953
name: acute-phase response
namespace: biological_process
def: "An acute inflammatory response that involves non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals." [ISBN:0198506732]
is_a: GO:0002526 ! acute inflammatory response

[Term]
id: GO:0006954
name: inflammatory response
namespace: biological_process
def: "The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages." [GO_REF:0000022, GOC:mtg_15nov05, ISBN:0198506732]
comment: This term was improved by GO_REF:0000022. It was moved.
synonym: "Inflammation" BROAD []
xref: Wikipedia:Inflammation
is_a: GO:0006952 ! defense response

[Term]
id: GO:0006955
name: immune response
namespace: biological_process
def: "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
comment: This term was improved by GO_REF:0000022. It was redefined and moved.
is_a: GO:0002376 ! immune system process
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0006956
name: complement activation
namespace: biological_process
def: "Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was improved by GO_REF:0000022. It was moved.
synonym: "complement activity" RELATED []
synonym: "complement cascade" EXACT [GOC:add]
synonym: "complement response" EXACT []
xref: Reactome:REACT_104612 "Initial triggering of complement, Rattus norvegicus"
xref: Reactome:REACT_109566 "Activation of C3 and C5, Danio rerio"
xref: Reactome:REACT_110133 "Initial triggering of complement, Gallus gallus"
xref: Reactome:REACT_77331 "Initial triggering of complement, Taeniopygia guttata"
xref: Reactome:REACT_79677 "Activation of C3 and C5, Mus musculus"
xref: Reactome:REACT_7972 "Activation of C3 and C5, Homo sapiens"
xref: Reactome:REACT_8024 "Initial triggering of complement, Homo sapiens"
xref: Reactome:REACT_84452 "Activation of C3 and C5, Canis familiaris"
xref: Reactome:REACT_85982 "Activation of C3 and C5, Sus scrofa"
xref: Reactome:REACT_86062 "Initial triggering of complement, Bos taurus"
xref: Reactome:REACT_86496 "Initial triggering of complement, Sus scrofa"
xref: Reactome:REACT_87754 "Initial triggering of complement, Danio rerio"
xref: Reactome:REACT_90337 "Initial triggering of complement, Xenopus tropicalis"
xref: Reactome:REACT_90790 "Activation of C3 and C5, Bos taurus"
xref: Reactome:REACT_91972 "Initial triggering of complement, Canis familiaris"
xref: Reactome:REACT_96182 "Initial triggering of complement, Mus musculus"
is_a: GO:0002252 ! immune effector process
is_a: GO:0002253 ! activation of immune response
is_a: GO:0006959 ! humoral immune response
is_a: GO:0072376 ! protein activation cascade

[Term]
id: GO:0006957
name: complement activation, alternative pathway
namespace: biological_process
def: "Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes." [GOC:add, ISBN:0781735149]
synonym: "complement cascade, alternative pathway" EXACT [GOC:add]
xref: Reactome:REACT_101301 "Alternative complement activation, Canis familiaris"
xref: Reactome:REACT_108135 "Alternative complement activation, Mus musculus"
xref: Reactome:REACT_31710 "Alternative complement activation, Xenopus tropicalis"
xref: Reactome:REACT_78161 "Alternative complement activation, Danio rerio"
xref: Reactome:REACT_79165 "Alternative complement activation, Taeniopygia guttata"
xref: Reactome:REACT_8001 "Alternative complement activation, Homo sapiens"
xref: Reactome:REACT_88078 "Alternative complement activation, Sus scrofa"
xref: Reactome:REACT_92027 "Alternative complement activation, Gallus gallus"
xref: Reactome:REACT_92574 "Alternative complement activation, Bos taurus"
is_a: GO:0006956 ! complement activation
is_a: GO:0045087 ! innate immune response

[Term]
id: GO:0006958
name: complement activation, classical pathway
namespace: biological_process
def: "Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes." [GOC:add, ISBN:0781735149]
synonym: "complement cascade, classical pathway" EXACT [GOC:add]
xref: Reactome:REACT_7956 "Classical antibody-mediated complement activation, Homo sapiens"
xref: Reactome:REACT_80245 "Classical antibody-mediated complement activation, Mus musculus"
xref: Reactome:REACT_80419 "Classical antibody-mediated complement activation, Xenopus tropicalis"
xref: Reactome:REACT_87428 "Classical antibody-mediated complement activation, Rattus norvegicus"
xref: Reactome:REACT_88484 "Classical antibody-mediated complement activation, Sus scrofa"
xref: Reactome:REACT_88541 "Classical antibody-mediated complement activation, Bos taurus"
is_a: GO:0006956 ! complement activation
relationship: part_of GO:0002455 ! humoral immune response mediated by circulating immunoglobulin

[Term]
id: GO:0006959
name: humoral immune response
namespace: biological_process
def: "An immune response mediated through a body fluid." [GOC:hb, ISBN:0198506732]
xref: Wikipedia:Humoral_immunity
is_a: GO:0006955 ! immune response

[Term]
id: GO:0006962
name: male-specific antibacterial humoral response
namespace: biological_process
def: "An immune response against bacteria, specific to males and mediated through a body fluid." [GOC:go_curators]
is_a: GO:0019731 ! antibacterial humoral response
is_a: GO:0050831 ! male-specific defense response to bacterium

[Term]
id: GO:0006963
name: positive regulation of antibacterial peptide biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antibacterial peptide biosynthesis." [GOC:mah, PMID:10973475]
synonym: "activation of antibacterial peptide biosynthetic process" NARROW []
synonym: "antibacterial peptide induction" EXACT []
synonym: "antibacterial polypeptide induction" EXACT []
synonym: "stimulation of antibacterial peptide biosynthetic process" NARROW []
synonym: "up regulation of antibacterial peptide biosynthetic process" EXACT []
synonym: "up-regulation of antibacterial peptide biosynthetic process" EXACT []
synonym: "upregulation of antibacterial peptide biosynthetic process" EXACT []
is_a: GO:0002803 ! positive regulation of antibacterial peptide production
is_a: GO:0002807 ! positive regulation of antimicrobial peptide biosynthetic process
is_a: GO:0002808 ! regulation of antibacterial peptide biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002780 ! antibacterial peptide biosynthetic process
relationship: positively_regulates GO:0002780 ! antibacterial peptide biosynthetic process

[Term]
id: GO:0006964
name: positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria." [GOC:mah, PMID:10973475]
synonym: "activation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" NARROW []
synonym: "anti-Gram-negative bacterial peptide induction" EXACT []
synonym: "anti-Gram-negative bacterial polypeptide induction" EXACT []
synonym: "stimulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" NARROW []
synonym: "up regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT []
synonym: "up-regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT []
synonym: "upregulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT []
is_a: GO:0002813 ! regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
is_a: GO:0006963 ! positive regulation of antibacterial peptide biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002812 ! biosynthetic process of antibacterial peptides active against Gram-negative bacteria
relationship: positively_regulates GO:0002812 ! biosynthetic process of antibacterial peptides active against Gram-negative bacteria

[Term]
id: GO:0006965
name: positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria." [GOC:mah, PMID:10973475]
synonym: "activation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" NARROW []
synonym: "anti-Gram-positive bacterial peptide induction" EXACT []
synonym: "anti-Gram-positive bacterial polypeptide induction" EXACT []
synonym: "stimulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" NARROW []
synonym: "up regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT []
synonym: "up-regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT []
synonym: "upregulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT []
is_a: GO:0002816 ! regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
is_a: GO:0006963 ! positive regulation of antibacterial peptide biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002815 ! biosynthetic process of antibacterial peptides active against Gram-positive bacteria
relationship: positively_regulates GO:0002815 ! biosynthetic process of antibacterial peptides active against Gram-positive bacteria

[Term]
id: GO:0006967
name: positive regulation of antifungal peptide biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antifungal peptide biosynthesis." [GOC:mah]
synonym: "activation of antifungal peptide biosynthetic process" NARROW []
synonym: "antifungal peptide induction" EXACT []
synonym: "antifungal polypeptide induction" EXACT []
synonym: "stimulation of antifungal peptide biosynthetic process" NARROW []
synonym: "up regulation of antifungal peptide biosynthetic process" EXACT []
synonym: "up-regulation of antifungal peptide biosynthetic process" EXACT []
synonym: "upregulation of antifungal peptide biosynthetic process" EXACT []
is_a: GO:0002804 ! positive regulation of antifungal peptide production
is_a: GO:0002807 ! positive regulation of antimicrobial peptide biosynthetic process
is_a: GO:0002810 ! regulation of antifungal peptide biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002783 ! antifungal peptide biosynthetic process
relationship: positively_regulates GO:0002783 ! antifungal peptide biosynthetic process

[Term]
id: GO:0006968
name: cellular defense response
namespace: biological_process
alt_id: GO:0016066
alt_id: GO:0016067
def: "A defense response that is mediated by cells." [GOC:ebc]
comment: Note that this term refers to any type of defense response made by any cell, whether only a single-celled organism or part of a multicellular organism; also includes responses that occur in the context of multiorganism processes.
synonym: "cellular defence response" EXACT []
is_a: GO:0006952 ! defense response

[Term]
id: GO:0006969
name: obsolete melanotic tumor response
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:add]
comment: This term was made obsolete because it was undefined and represented an abnormal process.
synonym: "melanotic mass response" EXACT []
synonym: "melanotic tumor response" EXACT []
is_obsolete: true

[Term]
id: GO:0006970
name: response to osmotic stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:jl]
subset: goslim_yeast
subset: gosubset_prok
synonym: "osmotic response" EXACT []
synonym: "osmotic stress response" EXACT []
is_a: GO:0006950 ! response to stress
is_a: GO:0009628 ! response to abiotic stimulus

[Term]
id: GO:0006971
name: hypotonic response
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell." [GOC:jl, PMID:12598593]
synonym: "hypo-osmotic response" EXACT []
is_a: GO:0006970 ! response to osmotic stress

[Term]
id: GO:0006972
name: hyperosmotic response
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell." [GOC:jl, PMID:12142009]
synonym: "HOG response" EXACT []
synonym: "hypertonic response" EXACT []
synonym: "response to hypertonicity" EXACT [GOC:mah, GOC:yaf]
is_a: GO:0006970 ! response to osmotic stress

[Term]
id: GO:0006973
name: intracellular accumulation of glycerol
namespace: biological_process
def: "The accumulation of glycerol within a cell, for example by increased glycerol biosynthesis combined with decreased permeability of the cell membrane to glycerol, in response to the detection of a hyperosmotic environment." [GOC:jl, PMID:11752666]
is_a: GO:0019725 ! cellular homeostasis
relationship: part_of GO:0071474 ! cellular hyperosmotic response

[Term]
id: GO:0006974
name: cellular response to DNA damage stimulus
namespace: biological_process
alt_id: GO:0034984
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
subset: goslim_yeast
subset: gosubset_prok
synonym: "cellular DNA damage response" EXACT []
synonym: "DNA damage response" EXACT []
synonym: "response to DNA damage stimulus" BROAD []
synonym: "response to genotoxic stress" EXACT []
is_a: GO:0033554 ! cellular response to stress

[Term]
id: GO:0006975
name: DNA damage induced protein phosphorylation
namespace: biological_process
def: "The widespread phosphorylation of various molecules, triggering many downstream processes, that occurs in response to the detection of DNA damage." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0006468 ! protein phosphorylation
is_a: GO:0006974 ! cellular response to DNA damage stimulus
is_a: GO:0044710 ! single-organism metabolic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0006977
name: DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
namespace: biological_process
def: "A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle." [GOC:go_curators]
synonym: "positive regulation of cell cycle arrest by p53-mediated DNA damage response" EXACT [GOC:dph, GOC:mah]
xref: Reactome:REACT_107178 "p53-Dependent G1 DNA Damage Response, Bos taurus"
xref: Reactome:REACT_108386 "p53-Dependent G1 DNA Damage Response, Danio rerio"
xref: Reactome:REACT_110524 "p53-Dependent G1 DNA Damage Response, Canis familiaris"
xref: Reactome:REACT_1625 "p53-Dependent G1 DNA Damage Response, Homo sapiens"
xref: Reactome:REACT_30327 "p53-Dependent G1 DNA Damage Response, Rattus norvegicus"
xref: Reactome:REACT_33731 "p53-Dependent G1 DNA Damage Response, Dictyostelium discoideum"
xref: Reactome:REACT_34116 "p53-Dependent G1 DNA Damage Response, Taeniopygia guttata"
xref: Reactome:REACT_80077 "p53-Dependent G1 DNA Damage Response, Arabidopsis thaliana"
xref: Reactome:REACT_81499 "p53-Dependent G1 DNA Damage Response, Mus musculus"
xref: Reactome:REACT_81576 "p53-Dependent G1 DNA Damage Response, Oryza sativa"
xref: Reactome:REACT_82172 "p53-Dependent G1 DNA Damage Response, Xenopus tropicalis"
xref: Reactome:REACT_87417 "p53-Dependent G1 DNA Damage Response, Gallus gallus"
xref: Reactome:REACT_97071 "p53-Dependent G1 DNA Damage Response, Sus scrofa"
is_a: GO:0030330 ! DNA damage response, signal transduction by p53 class mediator
is_a: GO:0071158 ! positive regulation of cell cycle arrest
is_a: GO:0072431 ! signal transduction involved in mitotic G1 DNA damage checkpoint

[Term]
id: GO:0006978
name: DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
namespace: biological_process
def: "A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, resulting in the induction of the transcription of p21 (also known as WAF1, CIP1 and SDI1) or any equivalent protein, in response to the detection of DNA damage." [PMID:10967424]
is_a: GO:0030330 ! DNA damage response, signal transduction by p53 class mediator
is_a: GO:0042772 ! DNA damage response, signal transduction resulting in transcription

[Term]
id: GO:0006979
name: response to oxidative stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
subset: goslim_yeast
subset: gosubset_prok
is_a: GO:0006950 ! response to stress

[Term]
id: GO:0006981
name: activation of SoxR protein
namespace: biological_process
def: "The conversion of the SoxR transcription factor to its active (oxidized) form." [GOC:jl, PMID:8816757]
subset: gosubset_prok
is_a: GO:0070887 ! cellular response to chemical stimulus
is_a: GO:0071461 ! cellular response to redox state

[Term]
id: GO:0006982
name: response to lipid hydroperoxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid hydroperoxide stimulus. Lipid hydroperoxide is the highly reactive primary oxygenated products of polyunsaturated fatty acids." [GOC:jl, PMID:10944149]
subset: gosubset_prok
synonym: "response to LHPO" EXACT []
is_a: GO:0010033 ! response to organic substance
is_a: GO:0033194 ! response to hydroperoxide

[Term]
id: GO:0006983
name: ER overload response
namespace: biological_process
def: "The series of molecular signals generated by the accumulation of normal or misfolded proteins in the endoplasmic reticulum and leading to activation of transcription by NF-kappaB." [PMID:10390516]
synonym: "endoplasmic reticulum overload response" EXACT []
synonym: "EOR" EXACT []
synonym: "ER-overload response" EXACT []
is_a: GO:0006984 ! ER-nucleus signaling pathway
is_a: GO:0034976 ! response to endoplasmic reticulum stress
is_a: GO:0071216 ! cellular response to biotic stimulus

[Term]
id: GO:0006984
name: ER-nucleus signaling pathway
namespace: biological_process
def: "Any series of molecular signals that conveys information from the endoplasmic reticulum to the nucleus, usually resulting in a change in transcriptional regulation." [GOC:mah]
synonym: "endoplasmic reticulum to nucleus signaling pathway" EXACT []
synonym: "endoplasmic reticulum-nuclear signaling pathway" EXACT []
synonym: "ER to nucleus signaling pathway" EXACT []
synonym: "ER to nucleus signalling pathway" EXACT []
synonym: "ER-nuclear signaling pathway" EXACT []
synonym: "ER-nuclear signalling pathway" EXACT []
is_a: GO:0007165 ! signal transduction

[Term]
id: GO:0006985
name: positive regulation of NF-kappaB transcription factor activity by ER overload response
namespace: biological_process
def: "The conversion of inactive NF-kappaB to the active form, thereby allowing it to activate transcription of target genes, as a result of signaling from the endoplasmic reticulum." [GOC:dph, GOC:mah, GOC:tb, PMID:10390516]
synonym: "EOR-mediated activation of NF-kappaB" EXACT [GOC:dph, GOC:tb]
synonym: "EOR-mediated NF-kappaB activation" EXACT []
synonym: "positive regulation of NF-kappaB transcription factor activity by EOR" EXACT [GOC:dph, GOC:tb]
is_a: GO:0006983 ! ER overload response
is_a: GO:0051092 ! positive regulation of NF-kappaB transcription factor activity

[Term]
id: GO:0006986
name: response to unfolded protein
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus." [GOC:jl]
comment: Note that this term should not be confused with 'unfolded protein response ; GO:0030968', which refers to one specific response to the presence of unfolded proteins in the ER.
subset: gosubset_prok
synonym: "heat shock protein activity" RELATED []
is_a: GO:0035966 ! response to topologically incorrect protein

[Term]
id: GO:0006987
name: activation of signaling protein activity involved in unfolded protein response
namespace: biological_process
def: "The conversion of a specific protein, possessing protein kinase and endoribonuclease activities, to an active form as a result of signaling via the unfolded protein response." [GOC:dph, GOC:mah, GOC:tb, PMID:12042763]
synonym: "unfolded protein response, activation of signaling protein activity" EXACT [GOC:dph, GOC:tb]
synonym: "unfolded protein response, activation of signaling protein kinase/endonuclease" EXACT []
synonym: "unfolded protein response, activation of signalling protein kinase/endonuclease" EXACT []
xref: Reactome:REACT_100135 "Activation of Chaperones by ATF6-alpha, Caenorhabditis elegans"
xref: Reactome:REACT_101995 "Activation of Chaperones by ATF6-alpha, Bos taurus"
xref: Reactome:REACT_102456 "Activation of Chaperones by IRE1alpha, Canis familiaris"
xref: Reactome:REACT_102628 "Activation of Chaperones by IRE1alpha, Schizosaccharomyces pombe"
xref: Reactome:REACT_104717 "Activation of Chaperones by ATF6-alpha, Taeniopygia guttata"
xref: Reactome:REACT_107638 "Activation of Chaperones by IRE1alpha, Gallus gallus"
xref: Reactome:REACT_107672 "Activation of Chaperones by ATF6-alpha, Gallus gallus"
xref: Reactome:REACT_108469 "PERK regulated gene expression, Mus musculus"
xref: Reactome:REACT_108913 "PERK regulated gene expression, Rattus norvegicus"
xref: Reactome:REACT_109000 "PERK regulated gene expression, Drosophila melanogaster"
xref: Reactome:REACT_109119 "Activation of Chaperones by ATF6-alpha, Drosophila melanogaster"
xref: Reactome:REACT_110952 "Activation of Chaperones by IRE1alpha, Bos taurus"
xref: Reactome:REACT_112328 "Activation of Chaperones by IRE1alpha, Dictyostelium discoideum"
xref: Reactome:REACT_113093 "Activation of Chaperones by IRE1alpha, Arabidopsis thaliana"
xref: Reactome:REACT_113185 "Activation of Chaperones by IRE1alpha, Oryza sativa"
xref: Reactome:REACT_114474 "Activation of Chaperones by IRE1alpha, Xenopus tropicalis"
xref: Reactome:REACT_18277 "PERK regulated gene expression, Homo sapiens"
xref: Reactome:REACT_18348 "Activation of Chaperones by ATF6-alpha, Homo sapiens"
xref: Reactome:REACT_18368 "Activation of Chaperones by IRE1alpha, Homo sapiens"
xref: Reactome:REACT_28146 "PERK regulated gene expression, Danio rerio"
xref: Reactome:REACT_30286 "Activation of Chaperones by IRE1alpha, Mus musculus"
xref: Reactome:REACT_30670 "Activation of Chaperones by IRE1alpha, Taeniopygia guttata"
xref: Reactome:REACT_30726 "Activation of Chaperones by ATF6-alpha, Sus scrofa"
xref: Reactome:REACT_31649 "Activation of Chaperones by IRE1alpha, Drosophila melanogaster"
xref: Reactome:REACT_34792 "PERK regulated gene expression, Sus scrofa"
xref: Reactome:REACT_78233 "Activation of Chaperones by IRE1alpha, Danio rerio"
xref: Reactome:REACT_79345 "PERK regulated gene expression, Xenopus tropicalis"
xref: Reactome:REACT_81109 "Activation of Chaperones by ATF6-alpha, Canis familiaris"
xref: Reactome:REACT_81367 "Activation of Chaperones by IRE1alpha, Caenorhabditis elegans"
xref: Reactome:REACT_82072 "Activation of Chaperones by IRE1alpha, Saccharomyces cerevisiae"
xref: Reactome:REACT_83153 "PERK regulated gene expression, Taeniopygia guttata"
xref: Reactome:REACT_84102 "PERK regulated gene expression, Bos taurus"
xref: Reactome:REACT_84533 "Activation of Chaperones by ATF6-alpha, Danio rerio"
xref: Reactome:REACT_90461 "Activation of Chaperones by ATF6-alpha, Mus musculus"
xref: Reactome:REACT_92946 "Activation of Chaperones by ATF6-alpha, Rattus norvegicus"
xref: Reactome:REACT_94487 "PERK regulated gene expression, Canis familiaris"
xref: Reactome:REACT_94509 "PERK regulated gene expression, Gallus gallus"
xref: Reactome:REACT_95923 "Activation of Chaperones by IRE1alpha, Rattus norvegicus"
xref: Reactome:REACT_98233 "Activation of Chaperones by ATF6-alpha, Xenopus tropicalis"
xref: Reactome:REACT_99540 "Activation of Chaperones by IRE1alpha, Sus scrofa"
is_a: GO:0032075 ! positive regulation of nuclease activity
is_a: GO:0045860 ! positive regulation of protein kinase activity
relationship: part_of GO:0030968 ! endoplasmic reticulum unfolded protein response

[Term]
id: GO:0006988
name: obsolete unfolded protein response, cleavage of primary transcript encoding UFP-specific transcription factor
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a function rather than a process.
synonym: "unfolded protein response, cleavage of primary transcript encoding UFP-specific transcription factor" EXACT []
is_obsolete: true
consider: GO:0004521
consider: GO:0030969

[Term]
id: GO:0006989
name: obsolete unfolded protein response, ligation of mRNA encoding UFP-specific transcription factor by RNA ligase
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a function rather than a process.
synonym: "unfolded protein response, ligation of mRNA encoding UFP-specific transcription factor by RNA ligase" EXACT []
is_obsolete: true
consider: GO:0008452
consider: GO:0030969

[Term]
id: GO:0006990
name: positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
namespace: biological_process
def: "The activation of genes whose promoters contain a specific sequence elements such as the unfolded protein response element (UPRE; consensus CAGCGTG) or the ER stress-response element (ERSE; CCAAN(N)9CCACG), as a result of signaling via the unfolded protein response." [GOC:dph, GOC:mah, GOC:tb, GOC:txnOH, PMID:12042763]
synonym: "positive regulation of transcription of target genes involved in unfolded protein response" EXACT [GOC:dph, GOC:tb]
synonym: "unfolded protein response, activation of target gene transcription" NARROW []
synonym: "unfolded protein response, positive regulation of target gene transcription" EXACT [GOC:tb]
synonym: "unfolded protein response, stimulation of target gene transcription" NARROW []
synonym: "unfolded protein response, target gene transcriptional activation" BROAD []
synonym: "unfolded protein response, up regulation of target gene transcription" EXACT []
synonym: "unfolded protein response, up-regulation of target gene transcription" EXACT []
synonym: "unfolded protein response, upregulation of target gene transcription" EXACT []
is_a: GO:1901522 ! positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
intersection_of: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
intersection_of: part_of GO:0030968 ! endoplasmic reticulum unfolded protein response
relationship: part_of GO:0030968 ! endoplasmic reticulum unfolded protein response

[Term]
id: GO:0006991
name: response to sterol depletion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating deprivation of sterols. Sterols are a group of steroids characterized by the presence of one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:bf, ISBN:0198506732]
synonym: "sterol depletion response" EXACT [GOC:dph, GOC:tb]
is_a: GO:0006950 ! response to stress

[Term]
id: GO:0006995
name: cellular response to nitrogen starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nitrogen." [GOC:jl]
subset: gosubset_prok
is_a: GO:0009267 ! cellular response to starvation
is_a: GO:0043562 ! cellular response to nitrogen levels

[Term]
id: GO:0006996
name: organelle organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah]
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_pir
subset: gosubset_prok
synonym: "organelle organisation" EXACT [GOC:curators]
synonym: "organelle organization and biogenesis" RELATED [GOC:dph, GOC:jl, GOC:mah]
is_a: GO:0016043 ! cellular component organization

[Term]
id: GO:0006997
name: nucleus organization
namespace: biological_process
alt_id: GO:0048287
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus." [GOC:dph, GOC:ems, GOC:jl, GOC:mah]
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_pir
subset: goslim_yeast
synonym: "nuclear morphology" RELATED []
synonym: "nuclear organisation" EXACT [GOC:curators]
synonym: "nuclear organization" EXACT [GOC:curators]
synonym: "nuclear organization and biogenesis" RELATED [GOC:mah]
synonym: "nucleus organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0006998
name: nuclear envelope organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope." [GOC:dph, GOC:ems, GOC:jl, GOC:mah]
synonym: "nuclear envelope organisation" EXACT [GOC:mah]
synonym: "nuclear envelope organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0044802 ! single-organism membrane organization
relationship: part_of GO:0006997 ! nucleus organization
relationship: part_of GO:0010256 ! endomembrane system organization

[Term]
id: GO:0006999
name: nuclear pore organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear pore." [GOC:dph, GOC:jid, GOC:jl, GOC:mah]
synonym: "nuclear pore complex organization and biogenesis" RELATED [GOC:mah]
synonym: "nuclear pore organisation" EXACT [GOC:curators]
synonym: "nuclear pore organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006997 ! nucleus organization
is_a: GO:0071822 ! protein complex subunit organization

[Term]
id: GO:0007000
name: nucleolus organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleolus." [GOC:dph, GOC:jid, GOC:jl, GOC:mah]
synonym: "nucleolus organisation" EXACT [GOC:curators]
synonym: "nucleolus organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006997 ! nucleus organization

[Term]
id: GO:0007002
name: obsolete centromere binding
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a molecular function and not a biological process.
synonym: "centromere binding" EXACT []
is_obsolete: true
replaced_by: GO:0019237

[Term]
id: GO:0007003
name: obsolete telomere binding
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a molecular function and not a biological process.
synonym: "telomere binding" EXACT []
is_obsolete: true
replaced_by: GO:0042162

[Term]
id: GO:0007004
name: telomere maintenance via telomerase
namespace: biological_process
def: "The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase." [GOC:elh]
synonym: "telomerase-dependent telomere maintenance" EXACT []
xref: Reactome:REACT_101633 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End, Sus scrofa"
xref: Reactome:REACT_102142 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End, Oryza sativa"
xref: Reactome:REACT_102453 "Alignment Of The RNA Template On The Telomeric Chromosome End, Gallus gallus"
xref: Reactome:REACT_102670 "Telomere Extension By Telomerase, Canis familiaris"
xref: Reactome:REACT_103846 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End, Saccharomyces cerevisiae"
xref: Reactome:REACT_104623 "Disassociation of Telomerase RNP and the Chromosome End, Mus musculus"
xref: Reactome:REACT_104705 "Elongation of Extended Telomeric Chromosome End, Saccharomyces cerevisiae"
xref: Reactome:REACT_104898 "Disassociation of Telomerase RNP and the Chromosome End, Oryza sativa"
xref: Reactome:REACT_104954 "Telomere Extension By Telomerase, Danio rerio"
xref: Reactome:REACT_105424 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End, Arabidopsis thaliana"
xref: Reactome:REACT_105597 "Recruitment of Telomerase RNP to the Telomeric Chromosome End, Danio rerio"
xref: Reactome:REACT_106277 "Telomere Extension By Telomerase, Saccharomyces cerevisiae"
xref: Reactome:REACT_106476 "Elongation Of The Telomeric Chromosome End, Bos taurus"
xref: Reactome:REACT_106788 "Telomere Extension By Telomerase, Arabidopsis thaliana"
xref: Reactome:REACT_108143 "Alignment Of The RNA Template On The Telomeric Chromosome End, Danio rerio"
xref: Reactome:REACT_108407 "Elongation of Extended Telomeric Chromosome End, Oryza sativa"
xref: Reactome:REACT_109182 "Disassociation of Telomerase RNP and the Chromosome End, Danio rerio"
xref: Reactome:REACT_109396 "Disassociation of Telomerase RNP and the Chromosome End, Taeniopygia guttata"
xref: Reactome:REACT_109443 "Elongation Of The Telomeric Chromosome End, Danio rerio"
xref: Reactome:REACT_110379 "Disassociation of Telomerase RNP and the Chromosome End, Arabidopsis thaliana"
xref: Reactome:REACT_110815 "Alignment Of The RNA Template On The Telomeric Chromosome End, Taeniopygia guttata"
xref: Reactome:REACT_112155 "Alignment Of The RNA Template On The Telomeric Chromosome End, Xenopus tropicalis"
xref: Reactome:REACT_112178 "Telomere Extension By Telomerase, Xenopus tropicalis"
xref: Reactome:REACT_113385 "Elongation Of The Telomeric Chromosome End, Xenopus tropicalis"
xref: Reactome:REACT_113614 "Recruitment of Telomerase RNP to the Telomeric Chromosome End, Xenopus tropicalis"
xref: Reactome:REACT_114466 "Elongation of Extended Telomeric Chromosome End, Xenopus tropicalis"
xref: Reactome:REACT_114887 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End, Xenopus tropicalis"
xref: Reactome:REACT_115312 "Disassociation of Telomerase RNP and the Chromosome End, Xenopus tropicalis"
xref: Reactome:REACT_116053 "Assembly of telomerase and telomere extension, Gallus gallus"
xref: Reactome:REACT_28249 "Elongation of Extended Telomeric Chromosome End, Gallus gallus"
xref: Reactome:REACT_28904 "Recruitment of Telomerase RNP to the Telomeric Chromosome End, Schizosaccharomyces pombe"
xref: Reactome:REACT_29584 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End, Taeniopygia guttata"
xref: Reactome:REACT_30494 "Elongation Of The Telomeric Chromosome End, Sus scrofa"
xref: Reactome:REACT_30995 "Elongation Of The Telomeric Chromosome End, Canis familiaris"
xref: Reactome:REACT_31549 "Elongation Of The Telomeric Chromosome End, Saccharomyces cerevisiae"
xref: Reactome:REACT_32154 "Recruitment of Telomerase RNP to the Telomeric Chromosome End, Mus musculus"
xref: Reactome:REACT_33436 "Elongation of Extended Telomeric Chromosome End, Danio rerio"
xref: Reactome:REACT_34258 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End, Danio rerio"
xref: Reactome:REACT_34434 "Alignment Of The RNA Template On The Telomeric Chromosome End, Canis familiaris"
xref: Reactome:REACT_60216 "Telomere Extension By Telomerase, Mus musculus"
xref: Reactome:REACT_77280 "Elongation of Extended Telomeric Chromosome End, Arabidopsis thaliana"
xref: Reactome:REACT_77948 "Recruitment of Telomerase RNP to the Telomeric Chromosome End, Arabidopsis thaliana"
xref: Reactome:REACT_78859 "Recruitment of Telomerase RNP to the Telomeric Chromosome End, Taeniopygia guttata"
xref: Reactome:REACT_7957 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End, Homo sapiens"
xref: Reactome:REACT_7960 "Recruitment of Telomerase RNP to the Telomeric Chromosome End, Homo sapiens"
xref: Reactome:REACT_7968 "Alignment Of The RNA Template On The Telomeric Chromosome End, Homo sapiens"
xref: Reactome:REACT_7974 "Telomere Extension By Telomerase, Homo sapiens"
xref: Reactome:REACT_7985 "Elongation of Extended Telomeric Chromosome End, Homo sapiens"
xref: Reactome:REACT_7996 "Disassociation of Telomerase RNP and the Chromosome End, Homo sapiens"
xref: Reactome:REACT_7997 "Biogenesis And Assembly Of The Telomerase RNP, Homo sapiens"
xref: Reactome:REACT_80069 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End, Schizosaccharomyces pombe"
xref: Reactome:REACT_8019 "Elongation Of The Telomeric Chromosome End, Homo sapiens"
xref: Reactome:REACT_80284 "Alignment Of The RNA Template On The Telomeric Chromosome End, Bos taurus"
xref: Reactome:REACT_80834 "Elongation Of The Telomeric Chromosome End, Mus musculus"
xref: Reactome:REACT_81690 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End, Mus musculus"
xref: Reactome:REACT_81691 "Elongation of Extended Telomeric Chromosome End, Canis familiaris"
xref: Reactome:REACT_82399 "Alignment Of The RNA Template On The Telomeric Chromosome End, Schizosaccharomyces pombe"
xref: Reactome:REACT_82993 "Telomere Extension By Telomerase, Bos taurus"
xref: Reactome:REACT_83597 "Disassociation of Telomerase RNP and the Chromosome End, Canis familiaris"
xref: Reactome:REACT_83792 "Disassociation of Telomerase RNP and the Chromosome End, Schizosaccharomyces pombe"
xref: Reactome:REACT_83982 "Elongation Of The Telomeric Chromosome End, Oryza sativa"
xref: Reactome:REACT_84007 "Recruitment of Telomerase RNP to the Telomeric Chromosome End, Bos taurus"
xref: Reactome:REACT_84520 "Alignment Of The RNA Template On The Telomeric Chromosome End, Mus musculus"
xref: Reactome:REACT_85286 "Elongation of Extended Telomeric Chromosome End, Bos taurus"
xref: Reactome:REACT_86045 "Alignment Of The RNA Template On The Telomeric Chromosome End, Arabidopsis thaliana"
xref: Reactome:REACT_86457 "Telomere Extension By Telomerase, Sus scrofa"
xref: Reactome:REACT_86666 "Elongation of Extended Telomeric Chromosome End, Sus scrofa"
xref: Reactome:REACT_87313 "Disassociation of Telomerase RNP and the Chromosome End, Bos taurus"
xref: Reactome:REACT_90274 "Alignment Of The RNA Template On The Telomeric Chromosome End, Sus scrofa"
xref: Reactome:REACT_90373 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End, Canis familiaris"
xref: Reactome:REACT_90823 "Elongation of Extended Telomeric Chromosome End, Mus musculus"
xref: Reactome:REACT_91078 "Disassociation of Telomerase RNP and the Chromosome End, Sus scrofa"
xref: Reactome:REACT_91963 "Recruitment of Telomerase RNP to the Telomeric Chromosome End, Oryza sativa"
xref: Reactome:REACT_92196 "Alignment Of The RNA Template On The Telomeric Chromosome End, Saccharomyces cerevisiae"
xref: Reactome:REACT_92694 "Recruitment of Telomerase RNP to the Telomeric Chromosome End, Sus scrofa"
xref: Reactome:REACT_93232 "Elongation Of The Telomeric Chromosome End, Schizosaccharomyces pombe"
xref: Reactome:REACT_93253 "Disassociation of Telomerase RNP and the Chromosome End, Saccharomyces cerevisiae"
xref: Reactome:REACT_93468 "Telomere Extension By Telomerase, Oryza sativa"
xref: Reactome:REACT_93868 "Recruitment of Telomerase RNP to the Telomeric Chromosome End, Canis familiaris"
xref: Reactome:REACT_93887 "Telomere Extension By Telomerase, Taeniopygia guttata"
xref: Reactome:REACT_94370 "Telomere Extension By Telomerase, Schizosaccharomyces pombe"
xref: Reactome:REACT_94534 "Elongation Of The Telomeric Chromosome End, Taeniopygia guttata"
xref: Reactome:REACT_94742 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End, Gallus gallus"
xref: Reactome:REACT_94768 "Elongation of Extended Telomeric Chromosome End, Schizosaccharomyces pombe"
xref: Reactome:REACT_95176 "Elongation Of The Telomeric Chromosome End, Gallus gallus"
xref: Reactome:REACT_96912 "Elongation of Extended Telomeric Chromosome End, Taeniopygia guttata"
xref: Reactome:REACT_97770 "Elongation Of The Telomeric Chromosome End, Arabidopsis thaliana"
xref: Reactome:REACT_97891 "Disassociation of Telomerase RNP and the Chromosome End, Gallus gallus"
xref: Reactome:REACT_98094 "Recruitment of Telomerase RNP to the Telomeric Chromosome End, Gallus gallus"
xref: Reactome:REACT_98962 "Telomere Extension By Telomerase, Gallus gallus"
xref: Reactome:REACT_99368 "Alignment Of The RNA Template On The Telomeric Chromosome End, Oryza sativa"
xref: Reactome:REACT_99394 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End, Bos taurus"
xref: Reactome:REACT_99699 "Recruitment of Telomerase RNP to the Telomeric Chromosome End, Saccharomyces cerevisiae"
is_a: GO:0006278 ! RNA-dependent DNA biosynthetic process
is_a: GO:0010833 ! telomere maintenance via telomere lengthening
is_a: GO:0044711 ! single-organism biosynthetic process
relationship: has_part GO:0003720 ! telomerase activity

[Term]
id: GO:0007005
name: mitochondrion organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_pir
subset: goslim_pombe
subset: goslim_yeast
synonym: "mitochondria organization" EXACT [GOC:mah]
synonym: "mitochondrion organisation" EXACT [GOC:mah]
synonym: "mitochondrion organization and biogenesis" RELATED [GOC:curators]
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0007006
name: mitochondrial membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
synonym: "mitochondrial membrane organisation" EXACT [GOC:curators]
synonym: "mitochondrial membrane organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0007005 ! mitochondrion organization
is_a: GO:0044802 ! single-organism membrane organization
is_a: GO:1902589 ! single-organism organelle organization
intersection_of: GO:0061024 ! membrane organization
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion

[Term]
id: GO:0007007
name: inner mitochondrial membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial inner membrane." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'.
synonym: "inner mitochondrial membrane organisation" EXACT [GOC:curators]
synonym: "inner mitochondrial membrane organization and biogenesis" RELATED [GOC:mah]
synonym: "mitochondrial inner membrane organization" EXACT [GOC:curators]
is_a: GO:0007006 ! mitochondrial membrane organization

[Term]
id: GO:0007008
name: outer mitochondrial membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial outer membrane." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
comment: See also the cellular component term 'mitochondrial outer membrane ; GO:0005741'.
synonym: "outer mitochondrial membrane organisation" EXACT [GOC:curators]
synonym: "outer mitochondrial membrane organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0007006 ! mitochondrial membrane organization

[Term]
id: GO:0007009
name: plasma membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]
subset: goslim_chembl
subset: goslim_generic
subset: gosubset_prok
synonym: "plasma membrane organisation" EXACT [GOC:curators]
synonym: "plasma membrane organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0044802 ! single-organism membrane organization
relationship: part_of GO:0010256 ! endomembrane system organization

[Term]
id: GO:0007010
name: cytoskeleton organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "cytoskeletal organization and biogenesis" RELATED [GOC:mah]
synonym: "cytoskeletal regulator activity" RELATED []
synonym: "cytoskeleton organisation" EXACT [GOC:curators]
synonym: "cytoskeleton organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0007011
name: obsolete regulation of cytoskeleton
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the organization, biogenesis or maintenance of the cytoskeleton." [GOC:go_curators]
comment: This term was made obsolete because cytoskeleton is neither a process nor a trait, so the term made no sense.
synonym: "regulation of cytoskeleton" EXACT []
is_obsolete: true
consider: GO:0007010

[Term]
id: GO:0007014
name: actin ubiquitination
namespace: biological_process
def: "The modification of actin by addition of ubiquitin groups." [GOC:mah]
synonym: "indirect flight muscle actin ubiquitination" NARROW [GOC:mah]
is_a: GO:0016567 ! protein ubiquitination
is_a: GO:0030047 ! actin modification

[Term]
id: GO:0007015
name: actin filament organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]
synonym: "actin filament organisation" EXACT [GOC:curators]
synonym: "regulation of actin filament localization" NARROW []
is_a: GO:0071822 ! protein complex subunit organization
relationship: part_of GO:0030036 ! actin cytoskeleton organization

[Term]
id: GO:0007016
name: cytoskeletal anchoring at plasma membrane
namespace: biological_process
def: "A cytoskeleton organization process that directly or indirectly links cytoskeletal filaments to the plasma membrane." [ISBN:0198599323]
synonym: "cytoskeletal anchoring activity" RELATED []
is_a: GO:0007010 ! cytoskeleton organization
is_a: GO:0032507 ! maintenance of protein location in cell
is_a: GO:1902589 ! single-organism organelle organization

[Term]
id: GO:0007017
name: microtubule-based process
namespace: biological_process
def: "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]
subset: goslim_chembl
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0007018
name: microtubule-based movement
namespace: biological_process
def: "A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
xref: Reactome:REACT_102513 "Axonal transport of NGF:Trk complexes, Danio rerio"
xref: Reactome:REACT_113466 "Axonal transport of NGF:Trk complexes, Caenorhabditis elegans"
xref: Reactome:REACT_12385 "Axonal transport of NGF:Trk complexes, Homo sapiens"
xref: Reactome:REACT_25201 "Kinesins, Homo sapiens"
xref: Reactome:REACT_31982 "Axonal transport of NGF:Trk complexes, Sus scrofa"
xref: Reactome:REACT_32872 "Axonal transport of NGF:Trk complexes, Mus musculus"
xref: Reactome:REACT_77014 "Axonal transport of NGF:Trk complexes, Drosophila melanogaster"
xref: Reactome:REACT_78584 "Axonal transport of NGF:Trk complexes, Gallus gallus"
xref: Reactome:REACT_87390 "Axonal transport of NGF:Trk complexes, Bos taurus"
xref: Reactome:REACT_89365 "Axonal transport of NGF:Trk complexes, Taeniopygia guttata"
xref: Reactome:REACT_94549 "Axonal transport of NGF:Trk complexes, Canis familiaris"
xref: Reactome:REACT_95164 "Axonal transport of NGF:Trk complexes, Xenopus tropicalis"
is_a: GO:0006928 ! movement of cell or subcellular component
is_a: GO:0007017 ! microtubule-based process

[Term]
id: GO:0007019
name: microtubule depolymerization
namespace: biological_process
def: "The removal of tubulin heterodimers from one or both ends of a microtubule." [ISBN:0815316194]
synonym: "microtubule catastrophe" NARROW [GOC:dph, GOC:tb]
synonym: "microtubule depolymerization during nuclear congression" NARROW []
synonym: "microtubule disassembly" EXACT []
synonym: "microtubule shortening" EXACT []
is_a: GO:0031109 ! microtubule polymerization or depolymerization
is_a: GO:0051261 ! protein depolymerization

[Term]
id: GO:0007020
name: microtubule nucleation
namespace: biological_process
def: "The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation)." [GOC:go_curators, ISBN:0815316194, PMID:12517712]
xref: Wikipedia:Microtubule_nucleation
is_a: GO:0000226 ! microtubule cytoskeleton organization
relationship: part_of GO:0046785 ! microtubule polymerization

[Term]
id: GO:0007021
name: tubulin complex assembly
namespace: biological_process
def: "The aggregation and bonding together of alpha- and beta-tubulin to form a tubulin heterodimer." [GOC:mah]
synonym: "tubulin assembly" EXACT []
synonym: "tubulin folding" RELATED []
synonym: "tubulin-specific chaperone activity" RELATED []
is_a: GO:0043623 ! cellular protein complex assembly

[Term]
id: GO:0007023
name: post-chaperonin tubulin folding pathway
namespace: biological_process
def: "Completion of folding of alpha- and beta-tubulin; takes place subsequent to chaperonin-mediated partial folding; mediated by a complex of folding cofactors." [PMID:10542094]
xref: Reactome:REACT_103702 "Post-chaperonin tubulin folding pathway, Danio rerio"
xref: Reactome:REACT_108127 "Post-chaperonin tubulin folding pathway, Sus scrofa"
xref: Reactome:REACT_108982 "Post-chaperonin tubulin folding pathway, Drosophila melanogaster"
xref: Reactome:REACT_112813 "Post-chaperonin tubulin folding pathway, Dictyostelium discoideum"
xref: Reactome:REACT_113555 "Post-chaperonin tubulin folding pathway, Plasmodium falciparum"
xref: Reactome:REACT_114764 "Post-chaperonin tubulin folding pathway, Caenorhabditis elegans"
xref: Reactome:REACT_115188 "Post-chaperonin tubulin folding pathway, Arabidopsis thaliana"
xref: Reactome:REACT_115383 "Post-chaperonin tubulin folding pathway, Oryza sativa"
xref: Reactome:REACT_16967 "Post-chaperonin tubulin folding pathway, Homo sapiens"
xref: Reactome:REACT_17065 "Post-chaperonin tubulin folding pathway, Bos taurus"
xref: Reactome:REACT_32907 "Post-chaperonin tubulin folding pathway, Canis familiaris"
xref: Reactome:REACT_76988 "Post-chaperonin tubulin folding pathway, Gallus gallus"
xref: Reactome:REACT_77475 "Post-chaperonin tubulin folding pathway, Taeniopygia guttata"
xref: Reactome:REACT_84358 "Post-chaperonin tubulin folding pathway, Rattus norvegicus"
xref: Reactome:REACT_86604 "Post-chaperonin tubulin folding pathway, Bos taurus"
xref: Reactome:REACT_94841 "Post-chaperonin tubulin folding pathway, Mus musculus"
xref: Reactome:REACT_99454 "Post-chaperonin tubulin folding pathway, Xenopus tropicalis"
is_a: GO:0006457 ! protein folding

[Term]
id: GO:0007026
name: negative regulation of microtubule depolymerization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol." [GOC:mah, ISBN:0815316194]
synonym: "down regulation of microtubule depolymerization" EXACT []
synonym: "down-regulation of microtubule depolymerization" EXACT []
synonym: "downregulation of microtubule depolymerization" EXACT []
synonym: "inhibition of microtubule depolymerization" NARROW []
synonym: "microtubule rescue" NARROW [GOC:dph, GOC:tb]
synonym: "microtubule stabilization" EXACT []
synonym: "negative regulation of microtubule catastrophe" NARROW [GOC:dph, GOC:tb]
synonym: "negative regulation of microtubule disassembly" EXACT []
is_a: GO:0031111 ! negative regulation of microtubule polymerization or depolymerization
is_a: GO:0031114 ! regulation of microtubule depolymerization
is_a: GO:1901880 ! negative regulation of protein depolymerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007019 ! microtubule depolymerization
relationship: negatively_regulates GO:0007019 ! microtubule depolymerization

[Term]
id: GO:0007027
name: negative regulation of axonemal microtubule depolymerization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the depolymerization of the specialized microtubules of the axoneme." [GOC:dph, GOC:mah]
synonym: "axonemal microtubule stabilization" EXACT []
synonym: "negative regulation of microtubule depolymerization in axoneme" RELATED [GOC:dph]
is_a: GO:0007026 ! negative regulation of microtubule depolymerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060404 ! axonemal microtubule depolymerization
relationship: negatively_regulates GO:0060404 ! axonemal microtubule depolymerization

[Term]
id: GO:0007028
name: cytoplasm organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cytoplasm. The cytoplasm is all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [GOC:curators, GOC:dph, GOC:jl, GOC:mah]
subset: goslim_pir
subset: gosubset_prok
synonym: "cytoplasm organisation" EXACT [GOC:curators]
synonym: "cytoplasm organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0016043 ! cellular component organization
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0007029
name: endoplasmic reticulum organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum." [GOC:dph, GOC:jl, GOC:mah]
subset: goslim_pir
synonym: "endoplasmic reticulum morphology" RELATED []
synonym: "endoplasmic reticulum organisation" EXACT [GOC:curators]
synonym: "endoplasmic reticulum organization and biogenesis" RELATED [GOC:mah]
synonym: "ER organisation" EXACT [GOC:curators]
synonym: "ER organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization
relationship: part_of GO:0010256 ! endomembrane system organization

[Term]
id: GO:0007030
name: Golgi organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]
subset: goslim_pir
synonym: "Golgi organisation" EXACT [GOC:curators]
synonym: "Golgi organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization
relationship: part_of GO:0010256 ! endomembrane system organization

[Term]
id: GO:0007031
name: peroxisome organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:mah]
subset: goslim_pir
subset: goslim_pombe
subset: goslim_yeast
synonym: "peroxisome organisation" EXACT [GOC:curators]
synonym: "peroxisome organization and biogenesis" RELATED [GOC:mah]
synonym: "peroxisome-assembly ATPase activity" RELATED []
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0007032
name: endosome organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes." [GOC:dph, GOC:jl, GOC:mah]
subset: goslim_pir
synonym: "endosome organisation" EXACT [GOC:curators]
synonym: "endosome organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0007033 ! vacuole organization
relationship: part_of GO:0010256 ! endomembrane system organization

[Term]
id: GO:0007033
name: vacuole organization
namespace: biological_process
alt_id: GO:0044086
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole." [GOC:mah]
subset: goslim_pir
subset: goslim_yeast
synonym: "vacuolar assembly" NARROW [GOC:mah]
synonym: "vacuole biogenesis" RELATED [GOC:mah]
synonym: "vacuole organisation" EXACT [GOC:curators]
synonym: "vacuole organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0007034
name: vacuolar transport
namespace: biological_process
def: "The directed movement of substances into, out of or within a vacuole." [GOC:ai]
subset: goslim_chembl
subset: goslim_generic
is_a: GO:1902582 ! single-organism intracellular transport

[Term]
id: GO:0007035
name: vacuolar acidification
namespace: biological_process
def: "Any process that reduces the pH of the vacuole, measured by the concentration of the hydrogen ion." [GOC:jid]
is_a: GO:0051452 ! intracellular pH reduction

[Term]
id: GO:0007036
name: vacuolar calcium ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of calcium ions in the vacuole or between a vacuole and its surroundings." [GOC:ai, GOC:mah]
is_a: GO:0006874 ! cellular calcium ion homeostasis
intersection_of: GO:0055074 ! calcium ion homeostasis
intersection_of: occurs_in GO:0005773 ! vacuole
relationship: occurs_in GO:0005773 ! vacuole

[Term]
id: GO:0007037
name: vacuolar phosphate transport
namespace: biological_process
def: "The directed movement of phosphates into, out of or within a vacuole." [GOC:ai]
is_a: GO:0006817 ! phosphate ion transport
is_a: GO:0007034 ! vacuolar transport

[Term]
id: GO:0007038
name: endocytosed protein transport to vacuole
namespace: biological_process
def: "The directed movement of proteins imported into a cell by endocytosis to the vacuole." [GOC:ai]
comment: See also the biological process term 'endocytosis ; GO:0006897'.
synonym: "delivery of endocytosed proteins to the vacuole" EXACT []
is_a: GO:0006886 ! intracellular protein transport
is_a: GO:0007034 ! vacuolar transport

[Term]
id: GO:0007039
name: protein catabolic process in the vacuole
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein in the vacuole, usually by the action of vacuolar proteases." [GOC:mah, GOC:vw]
synonym: "vacuolar protein breakdown" RELATED []
synonym: "vacuolar protein catabolic process" RELATED []
synonym: "vacuolar protein catabolism" RELATED []
synonym: "vacuolar protein degradation" RELATED []
is_a: GO:0044257 ! cellular protein catabolic process
intersection_of: GO:0030163 ! protein catabolic process
intersection_of: occurs_in GO:0005773 ! vacuole
relationship: occurs_in GO:0005773 ! vacuole

[Term]
id: GO:0007040
name: lysosome organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases." [GOC:mah]
synonym: "lysosome organisation" EXACT [GOC:curators]
synonym: "lysosome organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0080171 ! lytic vacuole organization

[Term]
id: GO:0007041
name: lysosomal transport
namespace: biological_process
def: "The directed movement of substances into, out of or within a lysosome." [GOC:ai]
is_a: GO:0007034 ! vacuolar transport

[Term]
id: GO:0007042
name: lysosomal lumen acidification
namespace: biological_process
def: "Any process that reduces the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion." [GOC:jid]
synonym: "lysosome pH reduction" EXACT [GOC:bf, GOC:rph]
is_a: GO:0007035 ! vacuolar acidification
is_a: GO:0035751 ! regulation of lysosomal lumen pH

[Term]
id: GO:0007043
name: cell-cell junction assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a junction between cells." [GOC:ai]
synonym: "intercellular junction assembly" EXACT []
is_a: GO:0034329 ! cell junction assembly
is_a: GO:0045216 ! cell-cell junction organization

[Term]
id: GO:0007044
name: cell-substrate junction assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate." [GOC:mah]
is_a: GO:0034329 ! cell junction assembly

[Term]
id: GO:0007045
name: cell-substrate adherens junction assembly
namespace: biological_process
def: "The aggregation, arrangement, and bonding together of a set of components to form a cell-substrate adherens junction." [GOC:mah]
synonym: "hemi-adherens junction assembly" RELATED [GOC:mah]
is_a: GO:0007044 ! cell-substrate junction assembly
is_a: GO:0034333 ! adherens junction assembly

[Term]
id: GO:0007048
name: obsolete oncogenesis
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a pathological process.
synonym: "oncogenesis" EXACT []
is_obsolete: true

[Term]
id: GO:0007049
name: cell cycle
namespace: biological_process
def: "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle]
subset: gocheck_do_not_manually_annotate
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "cell-division cycle" EXACT []
xref: Wikipedia:Cell_cycle
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0007050
name: cell cycle arrest
namespace: biological_process
def: "A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M)." [GOC:dph, GOC:mah, GOC:tb]
synonym: "arrest of cell cycle progression" EXACT []
synonym: "cessation of cell cycle" EXACT []
synonym: "termination of cell cycle" EXACT []
xref: Reactome:REACT_104854 "Energy dependent regulation of mTOR by LKB1-AMPK, Dictyostelium discoideum"
xref: Reactome:REACT_110745 "Energy dependent regulation of mTOR by LKB1-AMPK, Rattus norvegicus"
xref: Reactome:REACT_21387 "Energy dependent regulation of mTOR by LKB1-AMPK, Homo sapiens"
xref: Reactome:REACT_34173 "Energy dependent regulation of mTOR by LKB1-AMPK, Canis familiaris"
xref: Reactome:REACT_34536 "Energy dependent regulation of mTOR by LKB1-AMPK, Gallus gallus"
xref: Reactome:REACT_78416 "Energy dependent regulation of mTOR by LKB1-AMPK, Caenorhabditis elegans"
xref: Reactome:REACT_78593 "Energy dependent regulation of mTOR by LKB1-AMPK, Arabidopsis thaliana"
xref: Reactome:REACT_79397 "Energy dependent regulation of mTOR by LKB1-AMPK, Schizosaccharomyces pombe"
xref: Reactome:REACT_80257 "Energy dependent regulation of mTOR by LKB1-AMPK, Danio rerio"
xref: Reactome:REACT_80760 "Energy dependent regulation of mTOR by LKB1-AMPK, Taeniopygia guttata"
xref: Reactome:REACT_81821 "Energy dependent regulation of mTOR by LKB1-AMPK, Xenopus tropicalis"
xref: Reactome:REACT_84630 "Energy dependent regulation of mTOR by LKB1-AMPK, Drosophila melanogaster"
xref: Reactome:REACT_86872 "Energy dependent regulation of mTOR by LKB1-AMPK, Mus musculus"
xref: Reactome:REACT_90070 "Energy dependent regulation of mTOR by LKB1-AMPK, Bos taurus"
xref: Reactome:REACT_90301 "Energy dependent regulation of mTOR by LKB1-AMPK, Oryza sativa"
xref: Reactome:REACT_92874 "Energy dependent regulation of mTOR by LKB1-AMPK, Sus scrofa"
xref: Reactome:REACT_92909 "Energy dependent regulation of mTOR by LKB1-AMPK, Saccharomyces cerevisiae"
is_a: GO:0022402 ! cell cycle process
is_a: GO:0045786 ! negative regulation of cell cycle

[Term]
id: GO:0007051
name: spindle organization
namespace: biological_process
alt_id: GO:0043146
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart." [GOC:go_curators, GOC:mah]
synonym: "spindle organisation" EXACT [GOC:curators]
synonym: "spindle organization and biogenesis" RELATED [GOC:mah]
synonym: "spindle stabilization" RELATED []
is_a: GO:0000226 ! microtubule cytoskeleton organization
is_a: GO:0007026 ! negative regulation of microtubule depolymerization
is_a: GO:0022402 ! cell cycle process
is_a: GO:0071822 ! protein complex subunit organization

[Term]
id: GO:0007052
name: mitotic spindle organization
namespace: biological_process
alt_id: GO:0043148
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:go_curators, GOC:mah]
synonym: "mitotic spindle organisation" EXACT [GOC:curators]
synonym: "mitotic spindle organization and biogenesis" RELATED [GOC:mah]
synonym: "mitotic spindle stabilization" RELATED []
synonym: "spindle organization and biogenesis during mitosis" EXACT []
is_a: GO:0007051 ! spindle organization
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0007053
name: spindle assembly involved in male meiosis
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the spindle during a meiotic cell cycle in males. An example of this is found in Drosophila melanogaster." [GOC:mah]
is_a: GO:0090306 ! spindle assembly involved in meiosis
intersection_of: GO:0051225 ! spindle assembly
intersection_of: part_of GO:0007140 ! male meiosis
relationship: part_of GO:0007140 ! male meiosis

[Term]
id: GO:0007054
name: spindle assembly involved in male meiosis I
namespace: biological_process
def: "The formation of the spindle during meiosis I of a meiotic cell cycle in males. An example of this is found in Drosophila melanogaster." [GOC:mah]
synonym: "male meiosis I spindle assembly" RELATED []
is_a: GO:0007053 ! spindle assembly involved in male meiosis
intersection_of: GO:0051225 ! spindle assembly
intersection_of: part_of GO:0007141 ! male meiosis I
relationship: part_of GO:0007141 ! male meiosis I

[Term]
id: GO:0007055
name: spindle assembly involved in male meiosis II
namespace: biological_process
def: "The formation of the spindle during meiosis II of a meiotic cell cycle in males. An example of this is found in Drosophila melanogaster." [GOC:mah]
synonym: "male meiosis II spindle assembly" RELATED []
is_a: GO:0007053 ! spindle assembly involved in male meiosis
intersection_of: GO:0051225 ! spindle assembly
intersection_of: part_of GO:0007142 ! male meiosis II
relationship: part_of GO:0007142 ! male meiosis II

[Term]
id: GO:0007056
name: spindle assembly involved in female meiosis
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the spindle during a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster." [GOC:mah]
synonym: "female meiotic spindle assembly" RELATED []
is_a: GO:0090306 ! spindle assembly involved in meiosis
intersection_of: GO:0051225 ! spindle assembly
intersection_of: part_of GO:0007143 ! female meiotic division
relationship: part_of GO:0007143 ! female meiotic division

[Term]
id: GO:0007057
name: spindle assembly involved in female meiosis I
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the spindle during meiosis I of a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster." [GOC:mah]
synonym: "female meiosis I spindle assembly" RELATED []
is_a: GO:0007056 ! spindle assembly involved in female meiosis
intersection_of: GO:0051225 ! spindle assembly
intersection_of: part_of GO:0007144 ! female meiosis I
relationship: part_of GO:0007144 ! female meiosis I

[Term]
id: GO:0007058
name: spindle assembly involved in female meiosis II
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the spindle during meiosis II of a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster." [GOC:mah]
synonym: "female meiosis II spindle assembly" RELATED []
is_a: GO:0007056 ! spindle assembly involved in female meiosis
intersection_of: GO:0051225 ! spindle assembly
intersection_of: part_of GO:0007147 ! female meiosis II
relationship: part_of GO:0007147 ! female meiosis II

[Term]
id: GO:0007059
name: chromosome segregation
namespace: biological_process
def: "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_pir
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "chromosome division" EXACT []
synonym: "chromosome transmission" RELATED []
xref: Wikipedia:Chromosome_segregation
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0007060
name: male meiosis chromosome segregation
namespace: biological_process
def: "The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a male." [GOC:ai]
is_a: GO:0045132 ! meiotic chromosome segregation
relationship: part_of GO:0007140 ! male meiosis

[Term]
id: GO:0007062
name: sister chromatid cohesion
namespace: biological_process
def: "The cell cycle process in which the sister chromatids of a replicated chromosome are associated with each other." [GOC:jh, GOC:mah, ISBN:0815316194]
synonym: "sister chromatid alignment" RELATED []
xref: Reactome:REACT_115472 "Phosphorylation of the SA2 Cohesin Complex, Schizosaccharomyces pombe"
xref: Reactome:REACT_118229 "Phosphorylation of the SA2 Cohesin Complex, Taeniopygia guttata"
xref: Reactome:REACT_118307 "Phosphorylation of the SA2 Cohesin Complex, Gallus gallus"
xref: Reactome:REACT_118462 "Phosphorylation of the SA2 Cohesin Complex, Saccharomyces cerevisiae"
xref: Reactome:REACT_1481 "Phosphorylation of the SA2 Cohesin Complex, Homo sapiens"
xref: Reactome:REACT_30230 "Phosphorylation of the SA2 Cohesin Complex, Caenorhabditis elegans"
xref: Reactome:REACT_31519 "Phosphorylation of the SA2 Cohesin Complex, Danio rerio"
xref: Reactome:REACT_33003 "Phosphorylation of the SA2 Cohesin Complex, Dictyostelium discoideum"
xref: Reactome:REACT_82473 "Phosphorylation of the SA2 Cohesin Complex, Canis familiaris"
xref: Reactome:REACT_83187 "Phosphorylation of the SA2 Cohesin Complex, Mus musculus"
xref: Reactome:REACT_84080 "Phosphorylation of the SA2 Cohesin Complex, Xenopus tropicalis"
xref: Reactome:REACT_86014 "Phosphorylation of the SA2 Cohesin Complex, Bos taurus"
xref: Reactome:REACT_91684 "Phosphorylation of the SA2 Cohesin Complex, Drosophila melanogaster"
xref: Reactome:REACT_94817 "Phosphorylation of the SA2 Cohesin Complex, Rattus norvegicus"
is_a: GO:0022402 ! cell cycle process
is_a: GO:0051276 ! chromosome organization
is_a: GO:1902589 ! single-organism organelle organization
relationship: part_of GO:0000819 ! sister chromatid segregation

[Term]
id: GO:0007063
name: regulation of sister chromatid cohesion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sister chromatid cohesion." [GOC:go_curators]
is_a: GO:0033045 ! regulation of sister chromatid segregation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007062 ! sister chromatid cohesion
relationship: regulates GO:0007062 ! sister chromatid cohesion

[Term]
id: GO:0007064
name: mitotic sister chromatid cohesion
namespace: biological_process
def: "The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission." [GOC:ai, GOC:rn, PMID:10827941, PMID:11389843, PMID:14623866]
is_a: GO:0007062 ! sister chromatid cohesion
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0007062 ! sister chromatid cohesion
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0000070 ! mitotic sister chromatid segregation
relationship: part_of GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0007065
name: male meiosis sister chromatid cohesion
namespace: biological_process
def: "The joining of the sister chromatids of a replicated chromosome along the entire length of the chromosome that occurs during meiosis in a male." [GOC:ai]
is_a: GO:0051177 ! meiotic sister chromatid cohesion
relationship: part_of GO:0007140 ! male meiosis

[Term]
id: GO:0007066
name: female meiosis sister chromatid cohesion
namespace: biological_process
def: "The joining of the sister chromatids of a replicated chromosome along the entire length of the chromosome that occurs during meiosis in a female." [GOC:ai]
is_a: GO:0051177 ! meiotic sister chromatid cohesion
relationship: part_of GO:0007143 ! female meiotic division

[Term]
id: GO:0007067
name: mitotic nuclear division
namespace: biological_process
def: "A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
subset: goslim_chembl
subset: goslim_generic
synonym: "mitosis" EXACT []
xref: Wikipedia:Mitosis
is_a: GO:0000280 ! nuclear division
is_a: GO:1902589 ! single-organism organelle organization
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0000280 ! nuclear division
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0007068
name: negative regulation of transcription during mitosis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription during mitosis." [GOC:go_curators]
synonym: "down regulation of transcription during mitosis" EXACT [GOC:mah]
synonym: "down-regulation of transcription during mitosis" EXACT [GOC:mah]
synonym: "downregulation of transcription during mitosis" EXACT [GOC:mah]
synonym: "inhibition of transcription during mitosis" NARROW [GOC:mah]
synonym: "mitotic repression of transcription" EXACT []
synonym: "negative regulation of transcription, mitotic" EXACT [GOC:mah]
is_a: GO:0045892 ! negative regulation of transcription, DNA-templated
is_a: GO:0045896 ! regulation of transcription during mitosis

[Term]
id: GO:0007069
name: negative regulation of transcription from RNA polymerase I promoter during mitosis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase I promoter during mitosis." [GOC:go_curators]
synonym: "down regulation of transcription from RNA polymerase I promoter during mitosis" EXACT [GOC:mah]
synonym: "down-regulation of transcription from RNA polymerase I promoter during mitosis" EXACT [GOC:mah]
synonym: "downregulation of transcription from RNA polymerase I promoter during mitosis" EXACT [GOC:mah]
synonym: "inhibition of transcription from RNA polymerase I promoter during mitosis" NARROW [GOC:mah]
synonym: "mitotic repression of transcription from Pol I promoter" EXACT []
synonym: "negative regulation of transcription from Pol I promoter during mitosis" EXACT [GOC:mah]
synonym: "negative regulation of transcription from RNA polymerase I promoter, mitotic" EXACT [GOC:mah]
is_a: GO:0007068 ! negative regulation of transcription during mitosis
is_a: GO:0016479 ! negative regulation of transcription from RNA polymerase I promoter
is_a: GO:0046017 ! regulation of transcription from RNA polymerase I promoter, mitotic

[Term]
id: GO:0007070
name: negative regulation of transcription from RNA polymerase II promoter during mitosis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter during mitosis." [GOC:go_curators]
synonym: "down regulation of transcription from RNA polymerase II promoter during mitosis" EXACT [GOC:mah]
synonym: "down-regulation of transcription from RNA polymerase II promoter during mitosis" EXACT [GOC:mah]
synonym: "downregulation of transcription from RNA polymerase II promoter during mitosis" EXACT [GOC:mah]
synonym: "inhibition of transcription from RNA polymerase II promoter during mitosis" NARROW [GOC:mah]
synonym: "mitotic repression of transcription from Pol II promoter" EXACT []
synonym: "negative regulation of transcription from Pol II promoter during mitosis" EXACT [GOC:mah]
synonym: "negative regulation of transcription from RNA polymerase II promoter, mitotic" EXACT [GOC:mah]
is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
is_a: GO:0007068 ! negative regulation of transcription during mitosis
is_a: GO:0046021 ! regulation of transcription from RNA polymerase II promoter, mitotic

[Term]
id: GO:0007071
name: negative regulation of transcription from RNA polymerase III promoter during mitosis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase III promoter during mitosis." [GOC:go_curators]
synonym: "down regulation of transcription from RNA polymerase III promoter during mitosis" EXACT [GOC:mah]
synonym: "down-regulation of transcription from RNA polymerase III promoter during mitosis" EXACT [GOC:mah]
synonym: "downregulation of transcription from RNA polymerase III promoter during mitosis" EXACT [GOC:mah]
synonym: "inhibition of transcription from RNA polymerase III promoter during mitosis" NARROW [GOC:mah]
synonym: "mitotic repression of transcription from Pol III promoter" EXACT []
synonym: "negative regulation of transcription from Pol III promoter during mitosis" EXACT [GOC:mah]
synonym: "negative regulation of transcription from RNA polymerase III promoter, mitotic" EXACT [GOC:mah]
is_a: GO:0007068 ! negative regulation of transcription during mitosis
is_a: GO:0016480 ! negative regulation of transcription from RNA polymerase III promoter
is_a: GO:0046023 ! regulation of transcription from RNA polymerase III promoter, mitotic

[Term]
id: GO:0007072
name: positive regulation of transcription involved in exit from mitosis
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of transcription as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:isa_complete, GOC:tb]
synonym: "activation of transcription on exit from mitosis" NARROW [GOC:dph, GOC:tb]
is_a: GO:0045897 ! positive regulation of transcription during mitosis
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0045893 ! positive regulation of transcription, DNA-templated
intersection_of: part_of GO:0010458 ! exit from mitosis
relationship: part_of GO:0010458 ! exit from mitosis

[Term]
id: GO:0007073
name: positive regulation of transcription involved in exit from mitosis, from RNA polymerase I promoter
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase I promoter as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:tb]
synonym: "activation of transcription on exit from mitosis, from Pol I promoter" NARROW [GOC:dph, GOC:tb]
synonym: "activation of transcription on exit from mitosis, from RNA polymerase I promoter" NARROW []
is_a: GO:0007072 ! positive regulation of transcription involved in exit from mitosis

[Term]
id: GO:0007074
name: positive regulation of transcription involved in exit from mitosis, from RNA polymerase II promoter
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:tb]
synonym: "activation of transcription on exit from mitosis, from Pol II promoter" NARROW []
synonym: "activation of transcription on exit from mitosis, from RNA polymerase II promoter" NARROW []
is_a: GO:0007072 ! positive regulation of transcription involved in exit from mitosis

[Term]
id: GO:0007075
name: positive regulation of transcription involved in exit from mitosis, from RNA polymerase III promoter
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase III promoter as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:tb]
synonym: "activation of transcription on exit from mitosis, from Pol III promoter" NARROW []
synonym: "activation of transcription on exit from mitosis, from RNA polymerase III promoter" NARROW [GOC:dph, GOC:tb]
is_a: GO:0007072 ! positive regulation of transcription involved in exit from mitosis

[Term]
id: GO:0007076
name: mitotic chromosome condensation
namespace: biological_process
def: "The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194]
is_a: GO:0030261 ! chromosome condensation
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0030261 ! chromosome condensation
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0000070 ! mitotic sister chromatid segregation
relationship: part_of GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0007077
name: mitotic nuclear envelope disassembly
namespace: biological_process
def: "The cell cycle process in which the controlled breakdown of the nuclear envelope during mitotic cell division occurs." [GOC:bf]
synonym: "mitotic nuclear envelope breakdown" EXACT []
synonym: "mitotic nuclear envelope catabolism" EXACT []
synonym: "mitotic nuclear envelope degradation" EXACT []
is_a: GO:0051081 ! nuclear envelope disassembly
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0051081 ! nuclear envelope disassembly
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0007078
name: lamin depolymerization
namespace: biological_process
def: "The cell cycle process in which lamin is depolymerized." [GOC:jid]
is_a: GO:0051261 ! protein depolymerization
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:0007077 ! mitotic nuclear envelope disassembly

[Term]
id: GO:0007079
name: mitotic chromosome movement towards spindle pole
namespace: biological_process
alt_id: GO:0007082
def: "The cell cycle process in which the directed movement of chromosomes from the center of the spindle towards the spindle poles occurs. This mediates by the shortening of microtubules attached to the chromosomes, during mitosis." [GOC:ai]
synonym: "chromosome migration to spindle pole during mitosis" EXACT []
synonym: "chromosome movement towards spindle pole during mitosis" EXACT []
synonym: "mitotic chromosome movement" BROAD []
synonym: "mitotic chromosome movement to spindle pole" EXACT []
synonym: "mitotic sister chromosome movement towards spindle pole" EXACT []
synonym: "sister chromosome movement towards spindle pole during mitosis" EXACT []
is_a: GO:0051305 ! chromosome movement towards spindle pole
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0051305 ! chromosome movement towards spindle pole
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0000070 ! mitotic sister chromatid segregation
relationship: part_of GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0007080
name: mitotic metaphase plate congression
namespace: biological_process
def: "The cell cycle process in which chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the mitotic spindle, during mitosis." [GOC:mah, ISBN:0815316194]
is_a: GO:0051310 ! metaphase plate congression
is_a: GO:1902580 ! single-organism cellular localization
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0051310 ! metaphase plate congression
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0000070 ! mitotic sister chromatid segregation
relationship: part_of GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0007081
name: obsolete mitotic sister-chromatid adhesion release
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because the term name is ambiguous and appears to encompass two processes.
synonym: "mitotic sister-chromatid adhesion release" EXACT []
is_obsolete: true
consider: GO:0000070
consider: GO:0007064

[Term]
id: GO:0007083
name: mitotic chromosome decondensation
namespace: biological_process
def: "The cell cycle process in which chromosome structure is altered from the condensed form taken on during mitosis to the relaxed disperse form held in resting cells." [GOC:ai]
is_a: GO:0051312 ! chromosome decondensation
is_a: GO:1902589 ! single-organism organelle organization
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0051312 ! chromosome decondensation
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0000070 ! mitotic sister chromatid segregation
relationship: part_of GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0007084
name: mitotic nuclear envelope reassembly
namespace: biological_process
def: "The cell cycle process that results in reformation of the nuclear envelope during mitotic cell division." [GOC:ai]
is_a: GO:0031468 ! nuclear envelope reassembly
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0031468 ! nuclear envelope reassembly
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0007085
name: obsolete nuclear membrane vesicle binding to chromatin
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function.
synonym: "nuclear membrane vesicle binding to chromatin" EXACT []
is_obsolete: true
consider: GO:0003682

[Term]
id: GO:0007086
name: vesicle fusion with nuclear membrane involved in mitotic nuclear envelope reassembly
namespace: biological_process
def: "The cell cycle process that results in the joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the nucleus, and contributes to mitotic nuclear envelope reassembly." [GOC:jid, GOC:mah]
is_a: GO:0000740 ! nuclear membrane fusion
is_a: GO:0006906 ! vesicle fusion
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:0007084 ! mitotic nuclear envelope reassembly

[Term]
id: GO:0007087
name: mitotic nuclear pore complex reassembly
namespace: biological_process
def: "The cell cycle process in which nuclear pore complexes reform during mitotic cell division." [GOC:ai]
is_a: GO:0051292 ! nuclear pore complex assembly
is_a: GO:1902589 ! single-organism organelle organization
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:0007084 ! mitotic nuclear envelope reassembly

[Term]
id: GO:0007088
name: regulation of mitotic nuclear division
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitosis." [GOC:go_curators]
synonym: "regulation of mitosis" EXACT []
is_a: GO:0007346 ! regulation of mitotic cell cycle
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0051783 ! regulation of nuclear division
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007067 ! mitotic nuclear division
relationship: regulates GO:0007067 ! mitotic nuclear division

[Term]
id: GO:0007089
name: traversing start control point of mitotic cell cycle
namespace: biological_process
alt_id: GO:0000081
def: "A cell cycle process by which a cell commits to entering S phase via a positive feedback mechanism between the regulation of transcription and G1 CDK activity." [GOC:mtg_cell_cycle]
is_a: GO:1900087 ! positive regulation of G1/S transition of mitotic cell cycle

[Term]
id: GO:0007090
name: obsolete regulation of S phase of mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. A cell cycle process that modulates the frequency, rate or extent of the progression through the S phase of the mitotic cell cycle." [GOC:go_curators]
comment: This term was made obsolete as part of the cell cycle overhaul. This is because it was decided that cell cycle phases are intervals and so cannot be regulated, rather it is the transitions between the phases that are regulated.
synonym: "regulation of S phase of mitotic cell cycle" EXACT []
synonym: "regulation of S-phase of mitotic cell cycle" EXACT []
is_obsolete: true
consider: GO:0044772

[Term]
id: GO:0007091
name: metaphase/anaphase transition of mitotic cell cycle
namespace: biological_process
def: "The cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin." [GOC:mtg_cell_cycle, PMID:10465783]
synonym: "metaphase/anaphase transition by anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process" EXACT [GOC:vw]
synonym: "mitotic metaphase/anaphase transition" EXACT []
xref: Reactome:REACT_101540 "Mitotic Metaphase/Anaphase Transition, Gallus gallus"
xref: Reactome:REACT_1016 "Mitotic Metaphase/Anaphase Transition, Homo sapiens"
xref: Reactome:REACT_107946 "Mitotic Metaphase/Anaphase Transition, Drosophila melanogaster"
xref: Reactome:REACT_109352 "Mitotic Metaphase/Anaphase Transition, Taeniopygia guttata"
xref: Reactome:REACT_113057 "Mitotic Metaphase/Anaphase Transition, Schizosaccharomyces pombe"
xref: Reactome:REACT_118439 "Mitotic Metaphase/Anaphase Transition, Saccharomyces cerevisiae"
xref: Reactome:REACT_34753 "Mitotic Metaphase/Anaphase Transition, Bos taurus"
xref: Reactome:REACT_78536 "Mitotic Metaphase/Anaphase Transition, Xenopus tropicalis"
xref: Reactome:REACT_84703 "Mitotic Metaphase/Anaphase Transition, Danio rerio"
xref: Reactome:REACT_85795 "Mitotic Metaphase/Anaphase Transition, Canis familiaris"
xref: Reactome:REACT_88639 "Mitotic Metaphase/Anaphase Transition, Mus musculus"
xref: Reactome:REACT_91559 "Mitotic Metaphase/Anaphase Transition, Rattus norvegicus"
xref: Reactome:REACT_93452 "Mitotic Metaphase/Anaphase Transition, Dictyostelium discoideum"
xref: Reactome:REACT_96680 "Mitotic Metaphase/Anaphase Transition, Caenorhabditis elegans"
is_a: GO:0010965 ! regulation of mitotic sister chromatid separation
is_a: GO:0044772 ! mitotic cell cycle phase transition
is_a: GO:0044784 ! metaphase/anaphase transition of cell cycle
intersection_of: GO:0044784 ! metaphase/anaphase transition of cell cycle
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0007067 ! mitotic nuclear division

[Term]
id: GO:0007092
name: activation of APC-Cdc20 complex activity
namespace: biological_process
def: "Any process that initiates the ubiquitin ligase activity of the APC-Cdc20 complex that regulates the mitotic metaphase/anaphase transition." [GOC:dph, GOC:mah, GOC:tb, PMID:10871297]
synonym: "activation of mitotic anaphase-promoting complex activity" RELATED []
synonym: "activation of ubiquitin ligase activity of anaphase promoting complex during mitotic cell cycle" EXACT []
synonym: "activation of ubiquitin ligase activity of anaphase-promoting complex during mitotic cell cycle" EXACT []
synonym: "activation of ubiquitin ligase activity of APC during mitotic cell cycle" EXACT []
synonym: "anaphase promoting complex activation during mitotic cell cycle" EXACT []
synonym: "anaphase-promoting complex activation during mitotic cell cycle" EXACT []
synonym: "APC activation during mitotic cell cycle" EXACT []
synonym: "mitotic anaphase promoting complex activation" EXACT []
synonym: "mitotic anaphase promoting complex activator" NARROW []
synonym: "mitotic anaphase-promoting complex activation" EXACT []
synonym: "mitotic anaphase-promoting complex activator" NARROW []
synonym: "mitotic APC activation" EXACT []
synonym: "mitotic APC activator" NARROW []
xref: Reactome:REACT_101303 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Mus musculus"
xref: Reactome:REACT_101667 "Down Regulation of Emi1 through Phosphorylation of Emi1, Bos taurus"
xref: Reactome:REACT_104730 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Schizosaccharomyces pombe"
xref: Reactome:REACT_106225 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Canis familiaris"
xref: Reactome:REACT_109331 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Drosophila melanogaster"
xref: Reactome:REACT_110530 "Down Regulation of Emi1 through Phosphorylation of Emi1, Mus musculus"
xref: Reactome:REACT_1808 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Homo sapiens"
xref: Reactome:REACT_28555 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Xenopus tropicalis"
xref: Reactome:REACT_28824 "Down Regulation of Emi1 through Phosphorylation of Emi1, Danio rerio"
xref: Reactome:REACT_29914 "Down Regulation of Emi1 through Phosphorylation of Emi1, Canis familiaris"
xref: Reactome:REACT_496 "Down Regulation of Emi1 through Phosphorylation of Emi1, Homo sapiens"
xref: Reactome:REACT_77443 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Danio rerio"
xref: Reactome:REACT_77834 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Rattus norvegicus"
xref: Reactome:REACT_78539 "Down Regulation of Emi1 through Phosphorylation of Emi1, Xenopus tropicalis"
xref: Reactome:REACT_80665 "Down Regulation of Emi1 through Phosphorylation of Emi1, Taeniopygia guttata"
xref: Reactome:REACT_82751 "Down Regulation of Emi1 through Phosphorylation of Emi1, Rattus norvegicus"
xref: Reactome:REACT_85066 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Taeniopygia guttata"
xref: Reactome:REACT_86211 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Saccharomyces cerevisiae"
xref: Reactome:REACT_87593 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Gallus gallus"
xref: Reactome:REACT_91263 "Down Regulation of Emi1 through Phosphorylation of Emi1, Gallus gallus"
xref: Reactome:REACT_97458 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Dictyostelium discoideum"
xref: Reactome:REACT_99266 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Caenorhabditis elegans"
is_a: GO:0045842 ! positive regulation of mitotic metaphase/anaphase transition
is_a: GO:0051437 ! positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
is_a: GO:0051439 ! regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
is_a: GO:0051488 ! activation of anaphase-promoting complex activity
is_a: GO:1904668 ! positive regulation of ubiquitin protein ligase activity
intersection_of: GO:0051488 ! activation of anaphase-promoting complex activity
intersection_of: part_of GO:0007067 ! mitotic nuclear division
relationship: part_of GO:0007067 ! mitotic nuclear division
relationship: positively_regulates GO:0031145 ! anaphase-promoting complex-dependent catabolic process
relationship: positively_regulates GO:0090302 ! APC-Cdc20 complex activity

[Term]
id: GO:0007093
name: mitotic cell cycle checkpoint
namespace: biological_process
alt_id: GO:0031575
alt_id: GO:0071780
def: "A cell cycle checkpoint that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage." [GOC:mtg_cell_cycle]
synonym: "mitotic checkpoint" RELATED []
is_a: GO:0000075 ! cell cycle checkpoint
is_a: GO:0045930 ! negative regulation of mitotic cell cycle
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0000075 ! cell cycle checkpoint
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0007094
name: mitotic spindle assembly checkpoint
namespace: biological_process
def: "A cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle." [GOC:mtg_cell_cycle, PMID:12360190]
synonym: "Mad2-dependent checkpoint" NARROW []
synonym: "mitotic cell cycle spindle assembly checkpoint" EXACT []
xref: Reactome:REACT_101833 "Mitotic Spindle Checkpoint, Bos taurus"
xref: Reactome:REACT_103200 "Mitotic Spindle Checkpoint, Mus musculus"
xref: Reactome:REACT_106674 "Mitotic Spindle Checkpoint, Gallus gallus"
xref: Reactome:REACT_2137 "Mitotic Spindle Checkpoint, Homo sapiens"
xref: Reactome:REACT_30981 "Mitotic Spindle Checkpoint, Canis familiaris"
xref: Reactome:REACT_32836 "Mitotic Spindle Checkpoint, Drosophila melanogaster"
xref: Reactome:REACT_77438 "Mitotic Spindle Checkpoint, Taeniopygia guttata"
xref: Reactome:REACT_81200 "Mitotic Spindle Checkpoint, Rattus norvegicus"
xref: Reactome:REACT_82714 "Mitotic Spindle Checkpoint, Schizosaccharomyces pombe"
xref: Reactome:REACT_90101 "Mitotic Spindle Checkpoint, Oryza sativa"
xref: Reactome:REACT_93981 "Mitotic Spindle Checkpoint, Dictyostelium discoideum"
xref: Reactome:REACT_98348 "Mitotic Spindle Checkpoint, Sus scrofa"
xref: Reactome:REACT_98676 "Mitotic Spindle Checkpoint, Xenopus tropicalis"
xref: Reactome:REACT_98972 "Mitotic Spindle Checkpoint, Danio rerio"
xref: Reactome:REACT_99771 "Mitotic Spindle Checkpoint, Arabidopsis thaliana"
is_a: GO:0071173 ! spindle assembly checkpoint
is_a: GO:0071174 ! mitotic spindle checkpoint
intersection_of: GO:0071173 ! spindle assembly checkpoint
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0007095
name: mitotic G2 DNA damage checkpoint
namespace: biological_process
def: "A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle]
synonym: "mitotic cell cycle G2/M transition DNA damage checkpoint" EXACT []
is_a: GO:0031572 ! G2 DNA damage checkpoint
is_a: GO:0044773 ! mitotic DNA damage checkpoint
is_a: GO:0044818 ! mitotic G2/M transition checkpoint
intersection_of: GO:0031572 ! G2 DNA damage checkpoint
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0007096
name: regulation of exit from mitosis
namespace: biological_process
def: "Any process involved in the progression from anaphase/telophase to G1 that is associated with a conversion from high to low mitotic CDK activity." [GOC:rn]
is_a: GO:0007088 ! regulation of mitotic nuclear division
is_a: GO:1901990 ! regulation of mitotic cell cycle phase transition
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010458 ! exit from mitosis
relationship: regulates GO:0010458 ! exit from mitosis

[Term]
id: GO:0007097
name: nuclear migration
namespace: biological_process
def: "The directed movement of the nucleus." [GOC:ai]
synonym: "nuclear movement" EXACT []
synonym: "nucleus migration" EXACT []
is_a: GO:0040023 ! establishment of nucleus localization

[Term]
id: GO:0007098
name: centrosome cycle
namespace: biological_process
def: "The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle." [ISBN:0815316194]
is_a: GO:0022402 ! cell cycle process
is_a: GO:0051297 ! centrosome organization
is_a: GO:1902589 ! single-organism organelle organization

[Term]
id: GO:0007099
name: centriole replication
namespace: biological_process
def: "The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type." [GOC:kmv, ISBN:0815316194]
synonym: "centriole duplication" EXACT []
is_a: GO:0022402 ! cell cycle process
is_a: GO:0051297 ! centrosome organization
is_a: GO:0098534 ! centriole assembly
relationship: part_of GO:0051298 ! centrosome duplication

[Term]
id: GO:0007100
name: mitotic centrosome separation
namespace: biological_process
def: "Separation of duplicated centrosome components at the beginning of mitosis. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle." [ISBN:0815316194]
is_a: GO:0051299 ! centrosome separation
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0051299 ! centrosome separation
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0007067 ! mitotic nuclear division

[Term]
id: GO:0007101
name: male meiosis centrosome cycle
namespace: biological_process
def: "Centrosome duplication and separation in the context of a meiotic cell cycle in a male organism." [GOC:mah]
synonym: "centrosome cycle involved in male meiotic cell cycle" EXACT [GOC:dph, GOC:tb]
is_a: GO:0007098 ! centrosome cycle
is_a: GO:1903046 ! meiotic cell cycle process
intersection_of: GO:0007098 ! centrosome cycle
intersection_of: part_of GO:0007140 ! male meiosis
relationship: part_of GO:0007140 ! male meiosis
relationship: part_of GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0007105
name: cytokinesis, site selection
namespace: biological_process
alt_id: GO:0010687
def: "The process of marking the place where cytokinesis will occur." [GOC:mtg_cell_cycle]
subset: gosubset_prok
synonym: "site selection involved in cell cycle cytokinesis" EXACT []
synonym: "site selection involved in cytokinesis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0032506 ! cytokinetic process
relationship: part_of GO:0000910 ! cytokinesis

[Term]
id: GO:0007106
name: obsolete cytokinesis, protein recruitment
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it was not defined.
synonym: "cytokinesis, protein recruitment" EXACT []
is_obsolete: true

[Term]
id: GO:0007107
name: membrane addition at site of cytokinesis
namespace: biological_process
def: "Any process involved in the net addition of membrane at the site of cytokinesis; includes vesicle recruitment and fusion, local lipid synthesis and insertion." [GOC:clt]
synonym: "cytokinesis, membrane recruitment/generation" EXACT []
is_a: GO:0032506 ! cytokinetic process
is_a: GO:0044802 ! single-organism membrane organization

[Term]
id: GO:0007108
name: obsolete cytokinesis, initiation of separation
namespace: biological_process
def: "OBSOLETE. The process involved in starting cell separation." [GOC:clt, GOC:dph, GOC:tb]
comment: This term was obsoleted because it was vaguely defined and had very likely been used in error. Consider the child terms of cytokinesis related to ring positioning, assembly, ring constriction etc. which would be more appropriate.
synonym: "cytokinesis, initiation of separation" EXACT []
synonym: "initiation of separation involved in cytokinesis" EXACT [GOC:dph, GOC:tb]
is_obsolete: true

[Term]
id: GO:0007109
name: obsolete cytokinesis, completion of separation
namespace: biological_process
def: "OBSOLETE. The process of finishing cell separation, which results in two physically separated cells." [GOC:clt, GOC:dph, GOC:tb]
comment: This term was obsoleted because it was vaguely defined and had very likely been used in error. Consider the child terms of cytokinesis related to ring positioning, assembly, ring constriction etc. which would be more appropriate.
synonym: "completion of separation involved in cytokinesis" EXACT [GOC:dph, GOC:tb]
synonym: "cytokinesis, completion of separation" EXACT []
is_obsolete: true

[Term]
id: GO:0007110
name: meiosis I cytokinesis
namespace: biological_process
def: "A cell cycle process that results in the division of the cytoplasm of a cell after meiosis I, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]
synonym: "cytokinesis after meiosis I" EXACT []
is_a: GO:0033206 ! meiotic cytokinesis
intersection_of: GO:0033206 ! meiotic cytokinesis
intersection_of: part_of GO:0007127 ! meiosis I
relationship: part_of GO:0007127 ! meiosis I

[Term]
id: GO:0007111
name: meiosis II cytokinesis
namespace: biological_process
def: "A cell cycle process that results in the division of the cytoplasm of a cell after meiosis II, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]
synonym: "cytokinesis after meiosis II" EXACT []
is_a: GO:0033206 ! meiotic cytokinesis
intersection_of: GO:0033206 ! meiotic cytokinesis
intersection_of: part_of GO:0007135 ! meiosis II
relationship: part_of GO:0007135 ! meiosis II

[Term]
id: GO:0007112
name: male meiosis cytokinesis
namespace: biological_process
def: "A cell cycle process that occurs as part of the male meiotic cell cycle and results in the division of the cytoplasm of a cell to produce two daughter cells." [GOC:ai]
synonym: "cytokinesis after male meiosis" EXACT [GOC:dph, GOC:tb]
synonym: "cytokinesis involved in male meiotic cell cycle" EXACT [GOC:dph, GOC:tb]
is_a: GO:0033206 ! meiotic cytokinesis
intersection_of: GO:0000910 ! cytokinesis
intersection_of: part_of GO:0007140 ! male meiosis
relationship: part_of GO:0007140 ! male meiosis

[Term]
id: GO:0007113
name: endomitotic cell cycle
namespace: biological_process
def: "A mitotic cell cycle in which chromosomes are replicated and sister chromatids separate, but spindle formation, nuclear membrane breakdown and nuclear division do not occur, resulting in an increased number of chromosomes in the cell." [GOC:curators, GOC:dos, GOC:expert_vm]
comment: Note that this term should not be confused with 'abortive mitotic cell cycle ; GO:0033277'. Although abortive mitosis is sometimes called endomitosis, GO:0033277 refers to a process in which a mitotic spindle forms and chromosome separation begins.
synonym: "endomitosis" RELATED []
xref: Wikipedia:Mitosis#Endomitosis
is_a: GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0007114
name: cell budding
namespace: biological_process
def: "A form of asexual reproduction, occurring in certain bacteria and fungi (e.g. yeasts) and some primitive animals in which an individual arises from a daughter cell formed by pinching off a part of the parent cell. The budlike outgrowths so formed may sometimes remain attached to the parent cell." [ISBN:0198506732]
subset: goslim_candida
subset: goslim_yeast
subset: gosubset_prok
synonym: "budding" BROAD []
is_a: GO:0019954 ! asexual reproduction
is_a: GO:0032505 ! reproduction of a single-celled organism
is_a: GO:0051301 ! cell division

[Term]
id: GO:0007115
name: obsolete bud site selection/establishment of cell polarity (sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents two processes.
synonym: "bud site selection/establishment of cell polarity (sensu Saccharomyces)" EXACT []
is_obsolete: true
consider: GO:0000282
consider: GO:0030010

[Term]
id: GO:0007116
name: regulation of cell budding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the formation and growth of cell buds." [GOC:mah]
synonym: "regulation of budding" BROAD []
is_a: GO:0051302 ! regulation of cell division
is_a: GO:1903664 ! regulation of asexual reproduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007114 ! cell budding
relationship: regulates GO:0007114 ! cell budding

[Term]
id: GO:0007117
name: budding cell bud growth
namespace: biological_process
def: "The process in which the bud portion of a cell that reproduces by budding irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [GOC:go_curators]
synonym: "bud growth" BROAD []
is_a: GO:0022414 ! reproductive process
is_a: GO:0040007 ! growth
relationship: part_of GO:0007114 ! cell budding

[Term]
id: GO:0007118
name: budding cell apical bud growth
namespace: biological_process
def: "Growth at the tip of a bud, in a cell that reproduces by budding." [GOC:go_curators]
synonym: "apical bud growth" BROAD []
is_a: GO:0007117 ! budding cell bud growth

[Term]
id: GO:0007119
name: budding cell isotropic bud growth
namespace: biological_process
def: "Unlocalized bud growth such that the entire surface of the bud expands evenly, in a cell that reproduces by budding." [GOC:go_curators]
synonym: "isotropic bud growth" BROAD []
is_a: GO:0007117 ! budding cell bud growth

[Term]
id: GO:0007120
name: axial cellular bud site selection
namespace: biological_process
def: "The process of defining the next site of bud emergence adjacent to the last site of bud emergence on a budding cell." [GOC:clt]
synonym: "axial bud site selection" EXACT []
synonym: "axial budding" BROAD []
is_a: GO:0000282 ! cellular bud site selection
is_a: GO:0007114 ! cell budding

[Term]
id: GO:0007121
name: bipolar cellular bud site selection
namespace: biological_process
def: "The process of defining subsequent sites of bud emergence such that budding takes place at alternating poles of a budding cell." [GOC:clt]
synonym: "bipolar bud site selection" EXACT []
synonym: "bipolar budding" BROAD []
synonym: "polar budding" BROAD []
is_a: GO:0000282 ! cellular bud site selection
is_a: GO:0007114 ! cell budding

[Term]
id: GO:0007122
name: obsolete loss of asymmetric budding
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it is a phenotype rather than a biological process.
synonym: "loss of asymmetric budding" EXACT []
is_obsolete: true
consider: GO:0006033

[Term]
id: GO:0007123
name: obsolete bud scar accumulation
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it is a phenotype rather than a biological process.
synonym: "bud scar accumulation" EXACT []
is_obsolete: true
consider: GO:0000282

[Term]
id: GO:0007124
name: pseudohyphal growth
namespace: biological_process
def: "A pattern of cell growth that occurs in conditions of nitrogen limitation and abundant fermentable carbon source. Cells become elongated, switch to a unipolar budding pattern, remain physically attached to each other, and invade the growth substrate." [GOC:krc, PMID:11104818]
subset: goslim_candida
subset: goslim_yeast
is_a: GO:0016049 ! cell growth
is_a: GO:0070783 ! growth of unicellular organism as a thread of attached cells

[Term]
id: GO:0007125
name: obsolete invasive growth
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mcc]
comment: This term was made obsolete because it has been split into two new terms.
synonym: "invasive growth" EXACT []
is_obsolete: true
consider: GO:0001403
consider: GO:0044409

[Term]
id: GO:0007126
name: meiotic nuclear division
namespace: biological_process
def: "One of the two nuclear divisions that occur as part of the meiotic cell cycle." [GOC:dph, GOC:mah, PMID:9334324]
subset: goslim_pombe
synonym: "meiosis" BROAD []
is_a: GO:0000280 ! nuclear division
is_a: GO:1902589 ! single-organism organelle organization
is_a: GO:1903046 ! meiotic cell cycle process
intersection_of: GO:0000280 ! nuclear division
intersection_of: part_of GO:0051321 ! meiotic cell cycle
relationship: part_of GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0007127
name: meiosis I
namespace: biological_process
def: "The first meiotic nuclear division in which homologous chromosomes are paired and segregated from each other, producing two haploid daughter nuclei." [GOC:dph, GOC:jl, GOC:mtg_cell_cycle, PMID:9334324]
xref: Wikipedia:Meiosis#Meiosis_I
is_a: GO:0007126 ! meiotic nuclear division
relationship: ends_during GO:0007134 ! meiotic telophase I

[Term]
id: GO:0007128
name: meiotic prophase I
namespace: biological_process
def: "The cell cycle phase which is the first stage of meiosis I and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0051324 ! prophase
is_a: GO:0098764 ! meiosis I cell cycle phase

[Term]
id: GO:0007129
name: synapsis
namespace: biological_process
def: "The meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase. Synapsis begins when the chromosome arms begin to pair from the clustered telomeres and ends when synaptonemal complex or linear element assembly is complete." [GOC:mtg_cell_cycle, PMID:22582262, PMID:23117617]
synonym: "chromosomal pairing" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "chromosomal synapsis" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "homologous chromosome pairing at meiosis" EXACT []
xref: Wikipedia:Synapsis
is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle
relationship: part_of GO:0007127 ! meiosis I
relationship: part_of GO:0045143 ! homologous chromosome segregation

[Term]
id: GO:0007130
name: synaptonemal complex assembly
namespace: biological_process
def: "The cell cycle process in which the synaptonemal complex is formed. This is a structure that holds paired chromosomes together during prophase I of meiosis and that promotes genetic recombination." [ISBN:0198506732]
synonym: "synaptonemal complex formation" EXACT []
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle
is_a: GO:0070193 ! synaptonemal complex organization
relationship: part_of GO:0007129 ! synapsis

[Term]
id: GO:0007131
name: reciprocal meiotic recombination
namespace: biological_process
alt_id: GO:0000021
alt_id: GO:0007145
def: "The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity." [PMID:2087779]
synonym: "female meiotic recombination" NARROW []
synonym: "gene conversion with reciprocal crossover" EXACT []
is_a: GO:0035825 ! reciprocal DNA recombination
is_a: GO:0044710 ! single-organism metabolic process
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0007127 ! meiosis I

[Term]
id: GO:0007132
name: meiotic metaphase I
namespace: biological_process
def: "The cell cycle phase, following prophase I, during which chromosomes become aligned on the equatorial plate of the cell as part of meiosis I." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0051323 ! metaphase
is_a: GO:0098764 ! meiosis I cell cycle phase

[Term]
id: GO:0007133
name: meiotic anaphase I
namespace: biological_process
def: "The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of meiosis I." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0051322 ! anaphase
is_a: GO:0098764 ! meiosis I cell cycle phase
relationship: happens_during GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0007134
name: meiotic telophase I
namespace: biological_process
def: "The cell cycle phase which follows anaphase I of meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0051326 ! telophase
is_a: GO:0098764 ! meiosis I cell cycle phase

[Term]
id: GO:0007135
name: meiosis II
namespace: biological_process
def: "The second nuclear division of meiosis, in which the two chromatids in each chromosome are separated, resulting in four daughter nuclei from the two nuclei produced in meiosis II." [GOC:dph, GOC:mah, ISBN:0198547684]
xref: Wikipedia:Meiosis#Meiosis_II
is_a: GO:0007126 ! meiotic nuclear division

[Term]
id: GO:0007136
name: meiotic prophase II
namespace: biological_process
def: "The cell cycle phase which is the first stage of meiosis II and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0051324 ! prophase
is_a: GO:0098765 ! meiosis II cell cycle phase

[Term]
id: GO:0007137
name: meiotic metaphase II
namespace: biological_process
def: "The cell cycle phase, following prophase II, during which chromosomes become aligned on the equatorial plate of the cell as part of meiosis II." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0051323 ! metaphase
is_a: GO:0098765 ! meiosis II cell cycle phase

[Term]
id: GO:0007138
name: meiotic anaphase II
namespace: biological_process
def: "The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of meiosis II." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0051322 ! anaphase
is_a: GO:0098765 ! meiosis II cell cycle phase

[Term]
id: GO:0007139
name: meiotic telophase II
namespace: biological_process
def: "The cell cycle phase which follows anaphase II of meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0051326 ! telophase
is_a: GO:0098765 ! meiosis II cell cycle phase

[Term]
id: GO:0007140
name: male meiosis
namespace: biological_process
def: "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline." [GOC:dph, GOC:mah]
synonym: "male meiosis" BROAD []
is_a: GO:0007126 ! meiotic nuclear division

[Term]
id: GO:0007141
name: male meiosis I
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through male meiosis I, the first meiotic division in the male germline." [GOC:dph, GOC:mah]
is_a: GO:0007127 ! meiosis I
relationship: part_of GO:0007140 ! male meiosis

[Term]
id: GO:0007142
name: male meiosis II
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through male meiosis II, the second meiotic division in the male germline." [GOC:dph, GOC:mah]
is_a: GO:0007135 ! meiosis II
relationship: part_of GO:0007140 ! male meiosis

[Term]
id: GO:0007143
name: female meiotic division
namespace: biological_process
def: "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline." [GOC:dph, GOC:ems, GOC:mah]
comment: Note that female germ lines can be found in female or hermaphroditic organisms, so this term can be used to annotate gene products from hermaphrodites such as those of C. elegans. See also the biological process term 'meiosis ; GO:0007126'.
synonym: "female meiosis" BROAD []
is_a: GO:0007126 ! meiotic nuclear division

[Term]
id: GO:0007144
name: female meiosis I
namespace: biological_process
def: "The cell cycle process in which the first meiotic division occurs in the female germline." [GOC:mah]
is_a: GO:0007127 ! meiosis I
relationship: part_of GO:0007143 ! female meiotic division

[Term]
id: GO:0007146
name: meiotic recombination nodule assembly
namespace: biological_process
def: "During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form small, electron dense structures in association with meiotic chromosomes." [GOC:jl, PMID:9334324]
is_a: GO:0000707 ! meiotic DNA recombinase assembly

[Term]
id: GO:0007147
name: female meiosis II
namespace: biological_process
def: "The cell cycle process in which the second meiotic division occurs in the female germline." [GOC:mah]
is_a: GO:0007135 ! meiosis II
relationship: part_of GO:0007143 ! female meiotic division

[Term]
id: GO:0007149
name: obsolete colony morphology
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mcc]
comment: This term was made obsolete because it describes a phenotype rather than a biological goal.
synonym: "colony morphology" EXACT []
is_obsolete: true

[Term]
id: GO:0007150
name: obsolete growth pattern
namespace: biological_process
def: "OBSOLETE. A process whereby cells develop a specific morphology under a specific set of circumstances." [GOC:jid]
comment: This term was made obsolete because the original meaning of the term is unclear, the current definition is incorrect, and it does not describe a biological process.
synonym: "growth pattern" EXACT []
is_obsolete: true
consider: GO:0040007

[Term]
id: GO:0007154
name: cell communication
namespace: biological_process
def: "Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
xref: Wikipedia:Cell_signaling
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0007155
name: cell adhesion
namespace: biological_process
def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_pir
subset: goslim_pombe
subset: gosubset_prok
synonym: "cell adhesion molecule activity" RELATED []
xref: Wikipedia:Cell_adhesion
is_a: GO:0022610 ! biological adhesion

[Term]
id: GO:0007156
name: homophilic cell adhesion via plasma membrane adhesion molecules
namespace: biological_process
def: "The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules

[Term]
id: GO:0007157
name: heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
namespace: biological_process
def: "The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell." [ISBN:0198506732]
subset: gosubset_prok
synonym: "agglutination" RELATED [GOC:mah]
is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules

[Term]
id: GO:0007158
name: neuron cell-cell adhesion
namespace: biological_process
def: "The attachment of a neuron to another cell via adhesion molecules." [GOC:go_curators]
synonym: "neuron adhesion" EXACT [GOC:curators]
synonym: "neuronal cell adhesion" EXACT []
is_a: GO:0016337 ! single organismal cell-cell adhesion

[Term]
id: GO:0007159
name: leukocyte cell-cell adhesion
namespace: biological_process
def: "The attachment of a leukocyte to another cell via adhesion molecules." [GOC:go_curators]
synonym: "leukocyte adhesion" EXACT [GOC:curators]
synonym: "leukocyte cell adhesion" EXACT []
is_a: GO:0016337 ! single organismal cell-cell adhesion

[Term]
id: GO:0007160
name: cell-matrix adhesion
namespace: biological_process
def: "The binding of a cell to the extracellular matrix via adhesion molecules." [GOC:hb]
subset: gosubset_prok
is_a: GO:0031589 ! cell-substrate adhesion

[Term]
id: GO:0007161
name: calcium-independent cell-matrix adhesion
namespace: biological_process
def: "The binding of a cell to the extracellular matrix via adhesion molecules that do not require the presence of calcium for the interaction." [GOC:hb]
synonym: "calcium-independent cell adhesion molecule activity" RELATED []
is_a: GO:0007160 ! cell-matrix adhesion

[Term]
id: GO:0007162
name: negative regulation of cell adhesion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion." [GOC:go_curators]
synonym: "cell adhesion receptor inhibitor activity" RELATED []
synonym: "down regulation of cell adhesion" EXACT []
synonym: "down-regulation of cell adhesion" EXACT []
synonym: "downregulation of cell adhesion" EXACT []
synonym: "inhibition of cell adhesion" NARROW []
is_a: GO:0030155 ! regulation of cell adhesion
is_a: GO:0048523 ! negative regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007155 ! cell adhesion
relationship: negatively_regulates GO:0007155 ! cell adhesion

[Term]
id: GO:0007163
name: establishment or maintenance of cell polarity
namespace: biological_process
alt_id: GO:0030012
alt_id: GO:0030467
def: "Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah]
subset: goslim_pombe
synonym: "cell polarity" RELATED [GOC:mah, GOC:vw]
synonym: "establishment and/or maintenance of cell polarity" RELATED []
synonym: "establishment and/or maintenance of cell polarization" RELATED []
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0007164
name: establishment of tissue polarity
namespace: biological_process
def: "Coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates." [GOC:jid]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process

[Term]
id: GO:0007165
name: signal transduction
namespace: biological_process
alt_id: GO:0023033
def: "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
comment: Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not.
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_plant
subset: gosubset_prok
synonym: "signaling cascade" NARROW []
synonym: "signaling pathway" RELATED []
synonym: "signalling cascade" NARROW []
synonym: "signalling pathway" RELATED [GOC:mah]
xref: Reactome:REACT_100624 "EGFR interacts with phospholipase C-gamma, Gallus gallus"
xref: Reactome:REACT_102354 "EGFR interacts with phospholipase C-gamma, Canis familiaris"
xref: Reactome:REACT_112130 "EGFR interacts with phospholipase C-gamma, Oryza sativa"
xref: Reactome:REACT_112549 "EGFR interacts with phospholipase C-gamma, Arabidopsis thaliana"
xref: Reactome:REACT_113151 "EGFR interacts with phospholipase C-gamma, Mycobacterium tuberculosis"
xref: Reactome:REACT_113601 "EGFR interacts with phospholipase C-gamma, Drosophila melanogaster"
xref: Reactome:REACT_113964 "EGFR interacts with phospholipase C-gamma, Bos taurus"
xref: Reactome:REACT_114657 "EGFR interacts with phospholipase C-gamma, Dictyostelium discoideum"
xref: Reactome:REACT_114690 "EGFR interacts with phospholipase C-gamma, Saccharomyces cerevisiae"
xref: Reactome:REACT_114820 "EGFR interacts with phospholipase C-gamma, Sus scrofa"
xref: Reactome:REACT_114910 "EGFR interacts with phospholipase C-gamma, Caenorhabditis elegans"
xref: Reactome:REACT_115037 "EGFR interacts with phospholipase C-gamma, Plasmodium falciparum"
xref: Reactome:REACT_115147 "EGFR interacts with phospholipase C-gamma, Schizosaccharomyces pombe"
xref: Reactome:REACT_12478 "EGFR interacts with phospholipase C-gamma, Homo sapiens"
xref: Reactome:REACT_31232 "EGFR interacts with phospholipase C-gamma, Rattus norvegicus"
xref: Reactome:REACT_78535 "EGFR interacts with phospholipase C-gamma, Xenopus tropicalis"
xref: Reactome:REACT_89740 "EGFR interacts with phospholipase C-gamma, Taeniopygia guttata"
xref: Reactome:REACT_93680 "EGFR interacts with phospholipase C-gamma, Danio rerio"
xref: Reactome:REACT_98872 "EGFR interacts with phospholipase C-gamma, Mus musculus"
xref: Wikipedia:Signal_transduction
is_a: GO:0050794 ! regulation of cellular process
relationship: part_of GO:0007154 ! cell communication
relationship: part_of GO:0044700 ! single organism signaling
relationship: part_of GO:0051716 ! cellular response to stimulus

[Term]
id: GO:0007166
name: cell surface receptor signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, GOC:pr, GOC:signaling]
subset: gosubset_prok
synonym: "cell surface receptor linked signal transduction" EXACT []
synonym: "cell surface receptor linked signaling pathway" EXACT [GOC:bf]
synonym: "cell surface receptor linked signalling pathway" EXACT [GOC:mah]
xref: Reactome:REACT_6290 "DILP binds to Drosophila insulin receptor (DINR), Drosophila melanogaster"
is_a: GO:0007165 ! signal transduction

[Term]
id: GO:0007167
name: enzyme linked receptor protein signaling pathway
namespace: biological_process
def: "Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, ISBN:0185316194]
synonym: "enzyme linked receptor protein signalling pathway" EXACT []
is_a: GO:0007166 ! cell surface receptor signaling pathway

[Term]
id: GO:0007168
name: receptor guanylyl cyclase signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:16815030]
synonym: "receptor guanylyl cyclase signalling pathway" EXACT []
is_a: GO:0007167 ! enzyme linked receptor protein signaling pathway

[Term]
id: GO:0007169
name: transmembrane receptor protein tyrosine kinase signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]
synonym: "transmembrane receptor protein tyrosine kinase signalling pathway" EXACT []
xref: Reactome:REACT_101238 "Activation of TRKA receptors, Bos taurus"
xref: Reactome:REACT_104074 "Activation of TRKA receptors, Rattus norvegicus"
xref: Reactome:REACT_106114 "Activation of TRKA receptors, Sus scrofa"
xref: Reactome:REACT_106720 "Activation of TRKA receptors, Xenopus tropicalis"
xref: Reactome:REACT_108494 "Activation of TRKA receptors, Gallus gallus"
xref: Reactome:REACT_11064 "Activation of TRKA receptors, Homo sapiens"
xref: Reactome:REACT_29786 "Activation of TRKA receptors, Mus musculus"
xref: Reactome:REACT_82296 "Activation of TRKA receptors, Danio rerio"
xref: Reactome:REACT_90767 "Activation of TRKA receptors, Taeniopygia guttata"
xref: Reactome:REACT_97816 "Activation of TRKA receptors, Canis familiaris"
is_a: GO:0007167 ! enzyme linked receptor protein signaling pathway

[Term]
id: GO:0007170
name: obsolete transmembrane receptor protein tyrosine kinase ligand binding
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a function rather than a process.
synonym: "transmembrane receptor protein tyrosine kinase ligand binding" EXACT []
is_obsolete: true
consider: GO:0030971

[Term]
id: GO:0007171
name: activation of transmembrane receptor protein tyrosine kinase activity
namespace: biological_process
def: "Any process that initiates the activity of the inactive transmembrane receptor protein tyrosine kinase activity." [GOC:dph, GOC:tb]
synonym: "transmembrane receptor protein tyrosine kinase activation" RELATED [GOC:dph, GOC:tb]
synonym: "transmembrane receptor protein tyrosine kinase dimerization" RELATED [GOC:dph, GOC:mtg_lung]
is_a: GO:0032147 ! activation of protein kinase activity
is_a: GO:0043623 ! cellular protein complex assembly
relationship: part_of GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway

[Term]
id: GO:0007172
name: signal complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a complex capable of relaying a signal within a cell." [GOC:bf, GOC:signaling, PMID:9646862]
synonym: "signal complex formation" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0043623 ! cellular protein complex assembly

[Term]
id: GO:0007173
name: epidermal growth factor receptor signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, PR:000006933]
synonym: "EGF receptor signaling pathway" EXACT []
synonym: "EGF receptor signalling pathway" EXACT []
synonym: "EGFR signaling pathway" EXACT []
synonym: "epidermal growth factor receptor signalling pathway" EXACT []
synonym: "ERBB1 signaling pathway" EXACT [PR:000006933]
synonym: "receptor tyrosine-protein kinase erbB-1 signaling pathway" EXACT [PR:000006933]
xref: Reactome:REACT_104540 "Signaling by EGFR, Bos taurus"
xref: Reactome:REACT_106578 "Signaling by EGFR, Rattus norvegicus"
xref: Reactome:REACT_107420 "Signaling by EGFR, Xenopus tropicalis"
xref: Reactome:REACT_112423 "Signaling by EGFR, Arabidopsis thaliana"
xref: Reactome:REACT_114174 "Signaling by EGFR, Mycobacterium tuberculosis"
xref: Reactome:REACT_114791 "Signaling by EGFR, Dictyostelium discoideum"
xref: Reactome:REACT_114965 "Signaling by EGFR, Plasmodium falciparum"
xref: Reactome:REACT_115105 "Signaling by EGFR, Oryza sativa"
xref: Reactome:REACT_32523 "Signaling by EGFR, Gallus gallus"
xref: Reactome:REACT_32761 "Signaling by EGFR, Schizosaccharomyces pombe"
xref: Reactome:REACT_33745 "Signaling by EGFR, Taeniopygia guttata"
xref: Reactome:REACT_78847 "Signaling by EGFR, Danio rerio"
xref: Reactome:REACT_82411 "Signaling by EGFR, Mus musculus"
xref: Reactome:REACT_85346 "Signaling by EGFR, Saccharomyces cerevisiae"
xref: Reactome:REACT_87073 "Signaling by EGFR, Canis familiaris"
xref: Reactome:REACT_89544 "Signaling by EGFR, Caenorhabditis elegans"
xref: Reactome:REACT_89866 "Signaling by EGFR, Drosophila melanogaster"
xref: Reactome:REACT_9417 "Signaling by EGFR, Homo sapiens"
xref: Reactome:REACT_94427 "Signaling by EGFR, Sus scrofa"
is_a: GO:0038127 ! ERBB signaling pathway

[Term]
id: GO:0007174
name: epidermal growth factor catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of epidermal growth factor (EGF), following internalization of the receptor-bound ligand into the signal-receiving cell. Full breakdown of epidermal growth factor results in a ligand that is unable to bind and activate its receptor." [GOC:bf, GOC:signaling, PMID:2985587]
comment: This term describes the breakdown of epidermal growth factor within the cell, following internalization. For proteolysis events that result in the maturation of an epidermal growth factor receptor ligand, see 'epidermal growth factor receptor ligand maturation ; GO:'.
synonym: "EGF breakdown" EXACT [GOC:bf]
synonym: "EGF catabolism" EXACT [GOC:bf]
synonym: "EGF receptor ligand processing" RELATED [GOC:bf]
synonym: "epidermal growth factor breakdown" EXACT [GOC:bf]
synonym: "epidermal growth factor catabolism" EXACT [GOC:bf]
synonym: "epidermal growth factor ligand processing" RELATED [GOC:bf]
synonym: "intracellular EGF processing" RELATED [PMID:2985587]
synonym: "receptor-mediated EGF processing" RELATED [PMID:1683723]
is_a: GO:0042059 ! negative regulation of epidermal growth factor receptor signaling pathway
is_a: GO:0044257 ! cellular protein catabolic process

[Term]
id: GO:0007175
name: negative regulation of epidermal growth factor-activated receptor activity
namespace: biological_process
alt_id: GO:0007177
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of EGF-activated receptor activity." [GOC:go_curators]
synonym: "down regulation of epidermal growth factor receptor activity" EXACT []
synonym: "down-regulation of epidermal growth factor receptor activity" EXACT []
synonym: "downregulation of epidermal growth factor receptor activity" EXACT []
synonym: "EGF receptor downregulation" EXACT []
synonym: "inhibition of epidermal growth factor receptor activity" NARROW []
synonym: "negative regulation of EGF receptor activity" EXACT []
synonym: "negative regulation of EGFR activity" EXACT []
synonym: "negative regulation of epidermal growth factor receptor activity" EXACT [GOC:bf, GOC:signaling]
is_a: GO:0007176 ! regulation of epidermal growth factor-activated receptor activity
is_a: GO:0042059 ! negative regulation of epidermal growth factor receptor signaling pathway
is_a: GO:0061099 ! negative regulation of protein tyrosine kinase activity
is_a: GO:2000272 ! negative regulation of receptor activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0005006 ! epidermal growth factor-activated receptor activity
relationship: negatively_regulates GO:0005006 ! epidermal growth factor-activated receptor activity

[Term]
id: GO:0007176
name: regulation of epidermal growth factor-activated receptor activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of EGF-activated receptor activity." [GOC:dph, GOC:go_curators]
synonym: "regulation of EGF receptor activity" EXACT []
synonym: "regulation of EGFR activity" EXACT []
synonym: "regulation of epidermal growth factor receptor activity" EXACT [GOC:bf, GOC:signaling]
is_a: GO:0010469 ! regulation of receptor activity
is_a: GO:0042058 ! regulation of epidermal growth factor receptor signaling pathway
is_a: GO:0061097 ! regulation of protein tyrosine kinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0005006 ! epidermal growth factor-activated receptor activity
relationship: regulates GO:0005006 ! epidermal growth factor-activated receptor activity

[Term]
id: GO:0007178
name: transmembrane receptor protein serine/threonine kinase signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses serine/threonine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling]
synonym: "transmembrane receptor protein serine/threonine kinase signalling pathway" EXACT []
is_a: GO:0007167 ! enzyme linked receptor protein signaling pathway

[Term]
id: GO:0007179
name: transforming growth factor beta receptor signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:mah, GOC:signaling]
synonym: "TGF-beta receptor signaling pathway" EXACT []
synonym: "TGF-beta receptor signalling pathway" EXACT []
synonym: "TGFbeta receptor signaling pathway" EXACT []
synonym: "TGFbeta receptor signalling pathway" EXACT []
synonym: "transforming growth factor beta receptor signalling pathway" EXACT []
xref: Reactome:REACT_101958 "Signaling by TGF beta, Gallus gallus"
xref: Reactome:REACT_106912 "Signaling by TGF beta, Rattus norvegicus"
xref: Reactome:REACT_109530 "Signaling by TGF beta, Canis familiaris"
xref: Reactome:REACT_114882 "Signaling by TGF beta, Caenorhabditis elegans"
xref: Reactome:REACT_28222 "Signaling by TGF beta, Mus musculus"
xref: Reactome:REACT_28776 "Signaling by TGF beta, Taeniopygia guttata"
xref: Reactome:REACT_32950 "Signaling by TGF beta, Danio rerio"
xref: Reactome:REACT_6844 "Signaling by TGF beta, Homo sapiens"
xref: Reactome:REACT_78661 "Signaling by TGF beta, Sus scrofa"
xref: Reactome:REACT_79650 "Signaling by TGF beta, Xenopus tropicalis"
xref: Reactome:REACT_86676 "Signaling by TGF beta, Bos taurus"
xref: Reactome:REACT_96921 "Signaling by TGF beta, Drosophila melanogaster"
is_a: GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway
relationship: part_of GO:0071560 ! cellular response to transforming growth factor beta stimulus

[Term]
id: GO:0007180
name: obsolete transforming growth factor beta ligand binding to type II receptor
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a function.
synonym: "TGF-beta ligand binding to type II receptor" EXACT []
synonym: "TGFbeta ligand binding to type II receptor" EXACT []
synonym: "transforming growth factor beta ligand binding to type II receptor" EXACT []
is_obsolete: true
consider: GO:0005026
consider: GO:0005160
consider: GO:0050431

[Term]
id: GO:0007181
name: transforming growth factor beta receptor complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a ligand-bound type II transforming growth factor beta (TGF-beta) receptor dimer with a type I TGF-beta receptor dimer, following ligand binding, to form a heterotetrameric TGF-beta receptor complex." [GOC:jl, Reactome:REACT_7425, Wikipedia:TGF_beta_signaling_pathway]
synonym: "TGF-beta receptor complex assembly" EXACT []
synonym: "TGF-beta:type II receptor:type I receptor complex assembly" EXACT []
synonym: "TGFbeta receptor complex assembly" EXACT []
is_a: GO:0043623 ! cellular protein complex assembly
relationship: part_of GO:0007179 ! transforming growth factor beta receptor signaling pathway

[Term]
id: GO:0007182
name: common-partner SMAD protein phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group on to a common-partner SMAD protein. A common partner SMAD protein binds to pathway-restricted SMAD proteins forming a complex that translocates to the nucleus." [GOC:dph, ISBN:3527303782]
synonym: "common mediator SMAD protein phosphorylation" EXACT []
is_a: GO:0006468 ! protein phosphorylation
relationship: part_of GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway

[Term]
id: GO:0007183
name: SMAD protein complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a protein complex that contains SMAD proteins." [GOC:isa_complete]
synonym: "SMAD protein heteromerization" NARROW [GOC:mah, PMID:9670020]
is_a: GO:0043623 ! cellular protein complex assembly
relationship: part_of GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway

[Term]
id: GO:0007184
name: SMAD protein import into nucleus
namespace: biological_process
def: "The directed movement of a SMAD proteins from the cytoplasm into the nucleus. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:dph]
comment: Note that 'translocation' is sometimes used in the literature to refer to the entire process of protein import into the nucleus, but in GO refers specifically to the step in which a cargo-carrier protein complex moves through the nuclear pore complex.
synonym: "SMAD protein nuclear translocation" NARROW [GOC:mah]
is_a: GO:0006606 ! protein import into nucleus
relationship: part_of GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway

[Term]
id: GO:0007185
name: transmembrane receptor protein tyrosine phosphatase signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses protein tyrosine phosphatase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling]
synonym: "transmembrane receptor protein tyrosine phosphatase signalling pathway" EXACT []
is_a: GO:0007167 ! enzyme linked receptor protein signaling pathway

[Term]
id: GO:0007186
name: G-protein coupled receptor signaling pathway
namespace: biological_process
def: "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
synonym: "G protein coupled receptor protein signaling pathway" EXACT []
synonym: "G protein coupled receptor protein signalling pathway" EXACT []
synonym: "G-protein coupled receptor protein signal transduction" EXACT []
synonym: "G-protein coupled receptor protein signaling pathway" EXACT [GOC:bf]
synonym: "G-protein coupled receptor signalling pathway" EXACT []
synonym: "G-protein-coupled receptor protein signaling pathway" EXACT []
synonym: "G-protein-coupled receptor protein signalling pathway" EXACT []
synonym: "GPCR signaling pathway" EXACT []
synonym: "GPCR signalling pathway" EXACT []
is_a: GO:0007165 ! signal transduction

[Term]
id: GO:0007187
name: G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide." [GOC:mah, GOC:signaling, ISBN:0815316194]
synonym: "G protein signaling, coupled to cyclic nucleotide second messenger" EXACT []
synonym: "G protein signalling, coupled to cyclic nucleotide second messenger" EXACT []
synonym: "G-protein signaling, coupled to cyclic nucleotide second messenger" EXACT [GOC:signaling]
synonym: "G-protein signalling, coupled to cyclic nucleotide second messenger" EXACT []
synonym: "GPCR signaling pathway via cyclic nucleotide second messenger" EXACT [GOC:signaling]
is_a: GO:0007186 ! G-protein coupled receptor signaling pathway
relationship: has_part GO:0019935 ! cyclic-nucleotide-mediated signaling

[Term]
id: GO:0007188
name: adenylate cyclase-modulating G-protein coupled receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation or inhibition of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP (cAMP)." [GOC:mah, GOC:signaling, ISBN:0815316194]
comment: This term is intended to cover steps in a GPCR signaling pathway both upstream and downstream of adenylate-cyclase activity. For steps upstream of adenylate cyclase activity, consider instead annotating to 'regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway ; GO:0010578.
synonym: "adenylate cyclase-modulating GPCR signaling pathway" EXACT [GOC:signaling]
synonym: "G protein signaling, coupled to cAMP nucleotide second messenger" EXACT []
synonym: "G protein signaling, coupled to cyclic AMP nucleotide second messenger" EXACT []
synonym: "G protein signalling, coupled to cAMP nucleotide second messenger" EXACT []
synonym: "G protein signalling, coupled to cyclic AMP nucleotide second messenger" EXACT []
synonym: "G-protein signaling, coupled to cAMP nucleotide second messenger" EXACT [GOC:signaling]
synonym: "G-protein signaling, coupled to cyclic AMP nucleotide second messenger" EXACT []
synonym: "G-protein signalling, coupled to cAMP nucleotide second messenger" EXACT []
synonym: "G-protein signalling, coupled to cyclic AMP nucleotide second messenger" EXACT []
synonym: "GPCR signaling pathway via cAMP second messenger" EXACT [GOC:signaling]
synonym: "GPCR signaling pathway via modulation of adenylate cyclase activity" EXACT [GOC:signaling]
is_a: GO:0007187 ! G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
relationship: has_part GO:0019933 ! cAMP-mediated signaling
relationship: has_part GO:0043949 ! regulation of cAMP-mediated signaling
relationship: has_part GO:0045761 ! regulation of adenylate cyclase activity

[Term]
id: GO:0007189
name: adenylate cyclase-activating G-protein coupled receptor signaling pathway
namespace: biological_process
alt_id: GO:0010580
def: "The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]
comment: This term is intended to cover steps in a GPCR signaling pathway both upstream and downstream of adenylate-cyclase activity. For steps upstream of adenylate cyclase activity, consider instead annotating to 'positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway ; GO:0010579.
synonym: "activation of adenylate cyclase activity by G-protein signaling pathway" RELATED [GOC:bf]
synonym: "activation of adenylate cyclase activity involved in G-protein signaling" RELATED [GOC:signaling]
synonym: "adenylate cyclase-activating GPCR signaling pathway" EXACT [GOC:signaling]
synonym: "G protein signaling, adenylate cyclase activating pathway" EXACT []
synonym: "G protein signaling, adenylyl cyclase activating pathway" EXACT []
synonym: "G protein signalling, adenylate cyclase activating pathway" EXACT []
synonym: "G protein signalling, adenylyl cyclase activating pathway" EXACT []
synonym: "G-protein signaling, adenylate cyclase activating pathway" EXACT [GOC:dph, GOC:tb]
synonym: "G-protein signaling, adenylyl cyclase activating pathway" EXACT []
synonym: "G-protein signalling, adenylate cyclase activating pathway" EXACT []
synonym: "G-protein signalling, adenylyl cyclase activating pathway" EXACT []
synonym: "GPCR signaling pathway via activation of adenylate cyclase" EXACT [GOC:bf]
synonym: "GPCR signaling pathway via activation of adenylate cyclase activity" EXACT [GOC:signaling]
xref: Reactome:REACT_100197 "Adenylate cyclase activating pathway, Danio rerio"
xref: Reactome:REACT_100255 "Adenylate cyclase activating pathway, Bos taurus"
xref: Reactome:REACT_105267 "Adenylate cyclase activating pathway, Rattus norvegicus"
xref: Reactome:REACT_107738 "Adenylate cyclase activating pathway, Mus musculus"
xref: Reactome:REACT_15312 "Adenylate cyclase activating pathway, Homo sapiens"
xref: Reactome:REACT_31784 "Adenylate cyclase activating pathway, Canis familiaris"
xref: Reactome:REACT_79509 "Adenylate cyclase activating pathway, Drosophila melanogaster"
xref: Reactome:REACT_82718 "Adenylate cyclase activating pathway, Taeniopygia guttata"
xref: Reactome:REACT_83851 "Adenylate cyclase activating pathway, Gallus gallus"
xref: Reactome:REACT_99513 "Adenylate cyclase activating pathway, Caenorhabditis elegans"
xref: Reactome:REACT_99979 "Adenylate cyclase activating pathway, Xenopus tropicalis"
is_a: GO:0007188 ! adenylate cyclase-modulating G-protein coupled receptor signaling pathway
relationship: has_part GO:0007190 ! activation of adenylate cyclase activity
relationship: has_part GO:0043950 ! positive regulation of cAMP-mediated signaling

[Term]
id: GO:0007190
name: activation of adenylate cyclase activity
namespace: biological_process
def: "Any process that initiates the activity of the inactive enzyme adenylate cyclase." [GOC:ai]
synonym: "adenylate cyclase activation" EXACT [GOC:dph, GOC:tb]
synonym: "adenylate cyclase activator" RELATED []
synonym: "adenylyl cyclase activation" EXACT []
xref: Reactome:REACT_101359 "NGF-independant TRKA activation, Canis familiaris"
xref: Reactome:REACT_101410 "Galpha-olf:GTP binds to adenylate cyclase and activates it, Xenopus tropicalis"
xref: Reactome:REACT_103693 "NGF-independant TRKA activation, Danio rerio"
xref: Reactome:REACT_106393 "Galpha-olf:GTP binds to adenylate cyclase and activates it, Caenorhabditis elegans"
xref: Reactome:REACT_108102 "Galpha-olf:GTP binds to adenylate cyclase and activates it, Taeniopygia guttata"
xref: Reactome:REACT_11046 "NGF-independant TRKA activation, Homo sapiens"
xref: Reactome:REACT_15385 "Galpha-olf:GTP binds to adenylate cyclase and activates it, Homo sapiens"
xref: Reactome:REACT_28740 "NGF-independant TRKA activation, Sus scrofa"
xref: Reactome:REACT_28771 "Galpha-olf:GTP binds to adenylate cyclase and activates it, Gallus gallus"
xref: Reactome:REACT_29540 "NGF-independant TRKA activation, Mus musculus"
xref: Reactome:REACT_30807 "Galpha-olf:GTP binds to adenylate cyclase and activates it, Mus musculus"
xref: Reactome:REACT_33895 "NGF-independant TRKA activation, Xenopus tropicalis"
xref: Reactome:REACT_79377 "Galpha-olf:GTP binds to adenylate cyclase and activates it, Bos taurus"
xref: Reactome:REACT_79434 "Galpha-olf:GTP binds to adenylate cyclase and activates it, Danio rerio"
xref: Reactome:REACT_80878 "Galpha-olf:GTP binds to adenylate cyclase and activates it, Drosophila melanogaster"
xref: Reactome:REACT_81093 "NGF-independant TRKA activation, Rattus norvegicus"
xref: Reactome:REACT_84425 "NGF-independant TRKA activation, Gallus gallus"
xref: Reactome:REACT_86589 "Galpha-olf:GTP binds to adenylate cyclase and activates it, Rattus norvegicus"
xref: Reactome:REACT_88218 "NGF-independant TRKA activation, Bos taurus"
xref: Reactome:REACT_93143 "NGF-independant TRKA activation, Taeniopygia guttata"
xref: Reactome:REACT_98781 "Galpha-olf:GTP binds to adenylate cyclase and activates it, Canis familiaris"
is_a: GO:0045762 ! positive regulation of adenylate cyclase activity

[Term]
id: GO:0007191
name: adenylate cyclase-activating dopamine receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, where the pathway proceeds with activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP (cAMP)." [GOC:mah, GOC:signaling]
synonym: "activation of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:signaling]
synonym: "activation of adenylate cyclase activity by dopamine receptor signalling pathway" RELATED [GOC:mah]
synonym: "dopamine receptor, adenylate cyclase activating pathway" EXACT [GOC:dph, GOC:tb]
synonym: "dopamine receptor, adenylyl cyclase activating pathway" EXACT []
is_a: GO:0007189 ! adenylate cyclase-activating G-protein coupled receptor signaling pathway
is_a: GO:0007212 ! dopamine receptor signaling pathway

[Term]
id: GO:0007192
name: adenylate cyclase-activating serotonin receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a serotonin receptor binding to its physiological ligand, where the pathway proceeds with activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP (cAMP)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb]
synonym: "activation of adenylate cyclase activity by serotonin receptor signalling pathway" RELATED [GOC:mah]
synonym: "serotonin receptor, adenylate cyclase activating pathway" RELATED [GOC:dph, GOC:tb]
synonym: "serotonin receptor, adenylyl cyclase activating pathway" EXACT []
is_a: GO:0007189 ! adenylate cyclase-activating G-protein coupled receptor signaling pathway
is_a: GO:0007210 ! serotonin receptor signaling pathway

[Term]
id: GO:0007193
name: adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through inhibition of adenylyl cyclase activity and a subsequent decrease in the concentration of cyclic AMP (cAMP)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]
comment: This term is intended to cover steps in a GPCR signaling pathway both upstream and downstream of adenylate-cyclase inhibition.
synonym: "adenylate cyclase-inhibiting GPCR signaling pathway" EXACT [GOC:signaling]
synonym: "G protein signaling, adenylate cyclase inhibiting pathway" EXACT []
synonym: "G protein signaling, adenylyl cyclase inhibiting pathway" EXACT []
synonym: "G protein signalling, adenylate cyclase inhibiting pathway" EXACT []
synonym: "G protein signalling, adenylyl cyclase inhibiting pathway" EXACT []
synonym: "G-protein signaling, adenylate cyclase inhibiting pathway" EXACT [GOC:dph, GOC:tb]
synonym: "G-protein signaling, adenylyl cyclase inhibiting pathway" EXACT []
synonym: "G-protein signalling, adenylate cyclase inhibiting pathway" EXACT []
synonym: "G-protein signalling, adenylyl cyclase inhibiting pathway" EXACT []
synonym: "GPCR signaling pathway via inhibition of adenylate cyclase activity" EXACT [GOC:signaling]
synonym: "inhibition of adenylate cyclase activity by G-protein signaling pathway" RELATED [GOC:signaling]
xref: Reactome:REACT_100358 "Adenylate cyclase inhibitory pathway, Gallus gallus"
xref: Reactome:REACT_101453 "Adenylate cyclase inhibitory pathway, Canis familiaris"
xref: Reactome:REACT_110690 "Adenylate cyclase inhibitory pathway, Taeniopygia guttata"
xref: Reactome:REACT_15333 "Adenylate cyclase inhibitory pathway, Homo sapiens"
xref: Reactome:REACT_28094 "Adenylate cyclase inhibitory pathway, Xenopus tropicalis"
xref: Reactome:REACT_32432 "Adenylate cyclase inhibitory pathway, Mus musculus"
xref: Reactome:REACT_81583 "Adenylate cyclase inhibitory pathway, Danio rerio"
xref: Reactome:REACT_91960 "Adenylate cyclase inhibitory pathway, Bos taurus"
xref: Reactome:REACT_95919 "Adenylate cyclase inhibitory pathway, Rattus norvegicus"
xref: Reactome:REACT_95977 "Adenylate cyclase inhibitory pathway, Sus scrofa"
is_a: GO:0007188 ! adenylate cyclase-modulating G-protein coupled receptor signaling pathway
relationship: has_part GO:0007194 ! negative regulation of adenylate cyclase activity
relationship: has_part GO:0043951 ! negative regulation of cAMP-mediated signaling

[Term]
id: GO:0007194
name: negative regulation of adenylate cyclase activity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of adenylate cyclase activity." [GOC:go_curators]
synonym: "adenylate cyclase inhibitor" RELATED []
synonym: "down regulation of adenylate cyclase activity" EXACT []
synonym: "down-regulation of adenylate cyclase activity" EXACT []
synonym: "downregulation of adenylate cyclase activity" EXACT []
synonym: "inhibition of adenylate cyclase activity" NARROW []
synonym: "negative regulation of adenylyl cyclase activity" EXACT []
is_a: GO:0030818 ! negative regulation of cAMP biosynthetic process
is_a: GO:0031280 ! negative regulation of cyclase activity
is_a: GO:0045761 ! regulation of adenylate cyclase activity
is_a: GO:0051350 ! negative regulation of lyase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004016 ! adenylate cyclase activity
relationship: negatively_regulates GO:0004016 ! adenylate cyclase activity

[Term]
id: GO:0007195
name: adenylate cyclase-inhibiting dopamine receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb]
synonym: "dopamine receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:dph, GOC:tb]
synonym: "dopamine receptor, adenylyl cyclase inhibiting pathway" EXACT []
synonym: "inhibition of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:signaling]
synonym: "inhibition of adenylate cyclase activity by dopamine receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0007193 ! adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
is_a: GO:0007212 ! dopamine receptor signaling pathway

[Term]
id: GO:0007196
name: adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a G-protein coupled glutamate receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb]
synonym: "inhibition of adenylate cyclase activity by G-protein coupled glutamate receptor signaling pathway" RELATED [GOC:signaling]
synonym: "inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway" EXACT [GOC:bf]
synonym: "inhibition of adenylate cyclase activity by metabotropic glutamate receptor signalling pathway" EXACT [GOC:mah]
synonym: "metabotropic glutamate receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:dph, GOC:tb]
synonym: "metabotropic glutamate receptor, adenylyl cyclase inhibiting pathway" EXACT []
is_a: GO:0007193 ! adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
is_a: GO:0007216 ! G-protein coupled glutamate receptor signaling pathway

[Term]
id: GO:0007197
name: adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a G-protein coupled acetylcholine receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb]
synonym: "inhibition of adenylate cyclase activity by G-protein coupled acetylcholine receptor signaling pathway" RELATED [GOC:signaling]
synonym: "inhibition of adenylate cyclase activity by muscarinic acetylcholine receptor signaling pathway" RELATED [GOC:bf]
synonym: "inhibition of adenylate cyclase activity by muscarinic acetylcholine receptor signalling pathway" RELATED [GOC:mah]
synonym: "muscarinic acetylcholine receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:dph, GOC:tb]
synonym: "muscarinic acetylcholine receptor, adenylyl cyclase inhibiting pathway" EXACT []
is_a: GO:0007193 ! adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
is_a: GO:0007213 ! G-protein coupled acetylcholine receptor signaling pathway

[Term]
id: GO:0007198
name: adenylate cyclase-inhibiting serotonin receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a serotonin receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb]
synonym: "inhibition of adenylate cyclase activity by serotonin receptor signaling pathway" RELATED [GOC:signaling]
synonym: "inhibition of adenylate cyclase activity by serotonin receptor signalling pathway" RELATED [GOC:mah]
synonym: "serotonin receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:dph, GOC:tb]
synonym: "serotonin receptor, adenylyl cyclase inhibiting pathway" RELATED []
is_a: GO:0007193 ! adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
is_a: GO:0007210 ! serotonin receptor signaling pathway

[Term]
id: GO:0007199
name: G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by activation of guanylyl cyclase (GC) activity and a subsequent increase in the concentration of cyclic GMP (cGMP)." [GOC:mah, GOC:signaling, ISBN:0815316194]
synonym: "G protein signaling, coupled to cGMP nucleotide second messenger" EXACT []
synonym: "G protein signalling, coupled to cGMP nucleotide second messenger" EXACT []
synonym: "G-protein signaling, coupled to cGMP nucleotide second messenger" EXACT [GOC:signaling]
synonym: "G-protein signalling, coupled to cGMP nucleotide second messenger" EXACT []
synonym: "GPCR signaling pathway via activation of guanylate cyclase activity" EXACT [GOC:signaling]
synonym: "GPCR signaling pathway via cGMP second messenger" EXACT [GOC:signaling]
synonym: "guanylate cyclase-activating G-protein coupled receptor signaling pathway" EXACT [GOC:signaling]
is_a: GO:0007187 ! G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
relationship: has_part GO:0019934 ! cGMP-mediated signaling
relationship: has_part GO:0031284 ! positive regulation of guanylate cyclase activity

[Term]
id: GO:0007200
name: phospholipase C-activating G-protein coupled receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent increase in the concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]
comment: This term is intended to cover steps in a GPCR signaling pathway both upstream and downstream of phospholipase C (PLC) activity.
synonym: "activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger" RELATED [GOC:signaling]
synonym: "G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT []
synonym: "G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT []
synonym: "G-protein coupled receptor signaling pathway coupled to IP3 second messenger" EXACT [GOC:signaling]
synonym: "G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:dph, GOC:tb]
synonym: "G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT []
synonym: "phospholipase C-activating dopamine receptor signaling pathway" NARROW [GOC:dph, GOC:tb]
synonym: "PLC-activating GPCR signaling pathway" EXACT [GOC:signaling]
is_a: GO:0007186 ! G-protein coupled receptor signaling pathway
relationship: has_part GO:0007202 ! activation of phospholipase C activity
relationship: has_part GO:0048016 ! inositol phosphate-mediated signaling

[Term]
id: GO:0007201
name: obsolete G-protein dissociation
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because the dissociation of heterotrimeric G protein subunits is a consequence of a conformational change, which is in turn a consequence of ligand binding; it does not require multiple activities specifically to bring about.
synonym: "G-protein dissociation" EXACT []
is_obsolete: true

[Term]
id: GO:0007202
name: activation of phospholipase C activity
namespace: biological_process
def: "The initiation of the activity of the inactive enzyme phospolipase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand." [GOC:dph, GOC:mah, GOC:tb, PMID:8280098]
comment: Note that this term refers to a signaling pathway, and should not be confused with function terms such as 'phospholipase activator activity ; GO:0016004'.
synonym: "phospholipase C activation" EXACT [GOC:dph, GOC:tb]
xref: Reactome:REACT_110304 "PLC-gamma1 signalling, Saccharomyces cerevisiae"
xref: Reactome:REACT_114294 "PLC-gamma1 signalling, Plasmodium falciparum"
xref: Reactome:REACT_114701 "PLC-gamma1 signalling, Oryza sativa"
xref: Reactome:REACT_115230 "PLC-gamma1 signalling, Arabidopsis thaliana"
xref: Reactome:REACT_12079 "PLC-gamma1 signalling, Homo sapiens"
xref: Reactome:REACT_34721 "PLC-gamma1 signalling, Drosophila melanogaster"
xref: Reactome:REACT_77931 "PLC-gamma1 signalling, Taeniopygia guttata"
xref: Reactome:REACT_80677 "PLC-gamma1 signalling, Mycobacterium tuberculosis"
xref: Reactome:REACT_81004 "PLC-gamma1 signalling, Caenorhabditis elegans"
xref: Reactome:REACT_81031 "PLC-gamma1 signalling, Mus musculus"
xref: Reactome:REACT_82602 "PLC-gamma1 signalling, Dictyostelium discoideum"
xref: Reactome:REACT_84213 "PLC-gamma1 signalling, Xenopus tropicalis"
xref: Reactome:REACT_90615 "PLC-gamma1 signalling, Schizosaccharomyces pombe"
xref: Reactome:REACT_91465 "PLC-gamma1 signalling, Bos taurus"
xref: Reactome:REACT_92957 "PLC-gamma1 signalling, Danio rerio"
xref: Reactome:REACT_93158 "PLC-gamma1 signalling, Rattus norvegicus"
xref: Reactome:REACT_95868 "PLC-gamma1 signalling, Gallus gallus"
xref: Reactome:REACT_98083 "PLC-gamma1 signalling, Sus scrofa"
xref: Reactome:REACT_99019 "PLC-gamma1 signalling, Canis familiaris"
is_a: GO:0010863 ! positive regulation of phospholipase C activity

[Term]
id: GO:0007203
name: obsolete phosphatidylinositol-4,5-bisphosphate hydrolysis
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because hydrolysis is a reaction, not a process.
synonym: "phosphatidylinositol-4,5-bisphosphate hydrolysis" EXACT []
is_obsolete: true
consider: GO:0004435

[Term]
id: GO:0007204
name: positive regulation of cytosolic calcium ion concentration
namespace: biological_process
def: "Any process that increases the concentration of calcium ions in the cytosol." [GOC:ai]
synonym: "cytoplasmic calcium ion concentration elevation" BROAD []
synonym: "cytosolic calcium ion concentration elevation" EXACT []
synonym: "elevation of calcium ion concentration in cytoplasm" BROAD []
synonym: "elevation of calcium ion concentration in cytosol" EXACT []
synonym: "elevation of cytoplasmic calcium ion concentration" BROAD []
synonym: "elevation of cytosolic calcium ion concentration" EXACT []
is_a: GO:0051480 ! regulation of cytosolic calcium ion concentration

[Term]
id: GO:0007205
name: protein kinase C-activating G-protein coupled receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG)." [GOC:mah, GOC:signaling]
synonym: "activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway" RELATED [GOC:signaling]
synonym: "activation of protein kinase C activity by G-protein coupled receptor protein signalling pathway" RELATED [GOC:mah]
is_a: GO:0007186 ! G-protein coupled receptor signaling pathway
relationship: has_part GO:1990051 ! activation of protein kinase C activity

[Term]
id: GO:0007206
name: phospholipase C-activating G-protein coupled glutamate receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a G-protein coupled glutamate receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb]
synonym: "activation of phospholipase C activity by G-protein coupled glutamate receptor signaling pathway" RELATED [GOC:signaling]
synonym: "activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway" RELATED [GOC:bf]
synonym: "activation of phospholipase C activity by metabotropic glutamate receptor signalling pathway" RELATED [GOC:mah]
synonym: "metabotropic glutamate receptor, phospholipase C activating pathway" RELATED [GOC:dph, GOC:tb]
is_a: GO:0007200 ! phospholipase C-activating G-protein coupled receptor signaling pathway
is_a: GO:0007216 ! G-protein coupled glutamate receptor signaling pathway

[Term]
id: GO:0007207
name: phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a G-protein coupled acetylcholine receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb]
synonym: "activation of phospholipase C activity by G-protein coupled acetylcholine receptor signaling pathway" RELATED [GOC:signaling]
synonym: "activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway" RELATED [GOC:bf]
synonym: "activation of phospholipase C activity by muscarinic acetylcholine receptor signalling pathway" EXACT [GOC:mah]
synonym: "muscarinic acetylcholine receptor, phospholipase C activating pathway" RELATED [GOC:dph, GOC:tb]
synonym: "muscarinic receptor signaling pathway via activation of PLC" EXACT [GOC:signaling]
is_a: GO:0007200 ! phospholipase C-activating G-protein coupled receptor signaling pathway
is_a: GO:0007213 ! G-protein coupled acetylcholine receptor signaling pathway

[Term]
id: GO:0007208
name: phospholipase C-activating serotonin receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a serotonin receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb]
synonym: "activation of phospholipase C activity by serotonin receptor signaling pathway" RELATED [GOC:signaling]
synonym: "activation of phospholipase C activity by serotonin receptor signalling pathway" RELATED [GOC:mah]
synonym: "serotonin receptor, phospholipase C activating pathway" RELATED [GOC:dph, GOC:tb]
is_a: GO:0007200 ! phospholipase C-activating G-protein coupled receptor signaling pathway
is_a: GO:0007210 ! serotonin receptor signaling pathway

[Term]
id: GO:0007209
name: phospholipase C-activating tachykinin receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a tachykinin receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb]
synonym: "activation of phospholipase C activity by tachykinin receptor signaling pathway" RELATED [GOC:signaling]
synonym: "activation of phospholipase C activity by tachykinin receptor signalling pathway" RELATED [GOC:mah]
synonym: "tachykinin receptor, phospholipase C activating pathway" RELATED [GOC:dph, GOC:tb]
is_a: GO:0007200 ! phospholipase C-activating G-protein coupled receptor signaling pathway
is_a: GO:0007217 ! tachykinin receptor signaling pathway

[Term]
id: GO:0007210
name: serotonin receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands." [GOC:mah]
synonym: "serotonin receptor signalling pathway" EXACT []
is_a: GO:0007186 ! G-protein coupled receptor signaling pathway

[Term]
id: GO:0007211
name: octopamine or tyramine signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of octopamine or tyramine binding to a cell surface receptor. Octopamine and tyramine are decarboxylation products of tyrosine, and are the invertebrate counterparts of the vertebrate adrenergic transmitters." [GOC:mah, PMID:15355245]
synonym: "octopamine or tyramine signalling pathway" EXACT [GOC:mah]
synonym: "octopamine/tyramine signaling pathway" EXACT [GOC:mah]
is_a: GO:0007186 ! G-protein coupled receptor signaling pathway

[Term]
id: GO:0007212
name: dopamine receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands." [GOC:mah]
synonym: "dopamine receptor signalling pathway" EXACT []
is_a: GO:0007186 ! G-protein coupled receptor signaling pathway

[Term]
id: GO:0007213
name: G-protein coupled acetylcholine receptor signaling pathway
namespace: biological_process
def: "Any series of molecular signals initiated by an acetylcholine receptor on the surface of the target cell binding to one of its physiological ligands, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, ISBN:0815316194]
synonym: "acetylcholine receptor signalling, muscarinic pathway" EXACT []
synonym: "muscarinic acetylcholine receptor signaling pathway" EXACT [GOC:bf]
is_a: GO:0007186 ! G-protein coupled receptor signaling pathway
is_a: GO:0095500 ! acetylcholine receptor signaling pathway

[Term]
id: GO:0007214
name: gamma-aminobutyric acid signaling pathway
namespace: biological_process
def: "The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to a cell surface receptor." [GOC:mah]
synonym: "4-aminobutanoate signaling pathway" EXACT []
synonym: "4-aminobutanoate signalling pathway" EXACT []
synonym: "4-aminobutyrate signaling pathway" EXACT []
synonym: "4-aminobutyrate signalling pathway" EXACT []
synonym: "GABA signaling pathway" EXACT []
synonym: "GABA signalling pathway" EXACT []
synonym: "gamma-aminobutyric acid signalling pathway" EXACT []
is_a: GO:0007186 ! G-protein coupled receptor signaling pathway

[Term]
id: GO:0007215
name: glutamate receptor signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of glutamate to a glutamate receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:9131252]
synonym: "glutamate signaling pathway" EXACT [GOC:bf]
synonym: "glutamate signalling pathway" EXACT []
is_a: GO:0007166 ! cell surface receptor signaling pathway

[Term]
id: GO:0007216
name: G-protein coupled glutamate receptor signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. Ends with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:9131252]
synonym: "metabotropic glutamate receptor signaling pathway" EXACT [GOC:bf]
synonym: "metabotropic glutamate receptor signalling pathway" EXACT []
is_a: GO:0007186 ! G-protein coupled receptor signaling pathway
is_a: GO:0007215 ! glutamate receptor signaling pathway

[Term]
id: GO:0007217
name: tachykinin receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a tachykinin, i.e. a short peptide with the terminal sequence (Phe-X-Gly-Leu-Met-NH2), binding to a cell surface receptor." [GOC:mah, PMID:14723970]
synonym: "tachykinin signalling pathway" EXACT []
is_a: GO:0007186 ! G-protein coupled receptor signaling pathway

[Term]
id: GO:0007218
name: neuropeptide signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
synonym: "neuropeptide signalling pathway" EXACT []
is_a: GO:0007186 ! G-protein coupled receptor signaling pathway

[Term]
id: GO:0007219
name: Notch signaling pathway
namespace: biological_process
alt_id: GO:0030179
def: "A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]
synonym: "N signaling pathway" EXACT []
synonym: "N signalling pathway" EXACT []
synonym: "Notch receptor signaling pathway" EXACT []
synonym: "Notch receptor signalling pathway" EXACT []
synonym: "Notch signalling pathway" EXACT []
synonym: "Notch-receptor signaling pathway" EXACT []
synonym: "Notch-receptor signalling pathway" EXACT []
xref: Reactome:REACT_105675 "Signaling by Notch, Gallus gallus"
xref: Reactome:REACT_106624 "Signaling by Notch, Taeniopygia guttata"
xref: Reactome:REACT_107006 "Signaling by Notch, Bos taurus"
xref: Reactome:REACT_109213 "Signaling by Notch, Danio rerio"
xref: Reactome:REACT_299 "Signaling by Notch, Homo sapiens"
xref: Reactome:REACT_76949 "Signaling by Notch, Sus scrofa"
xref: Reactome:REACT_77691 "Signaling by Notch, Mus musculus"
xref: Reactome:REACT_78520 "Signaling by Notch, Drosophila melanogaster"
xref: Reactome:REACT_89792 "Signaling by Notch, Xenopus tropicalis"
xref: Reactome:REACT_91210 "Signaling by Notch, Rattus norvegicus"
xref: Reactome:REACT_91671 "Signaling by Notch, Canis familiaris"
xref: Wikipedia:Notch_signaling_pathway
is_a: GO:0007166 ! cell surface receptor signaling pathway

[Term]
id: GO:0007220
name: Notch receptor processing
namespace: biological_process
def: "The series of successive proteolytic cleavages of the Notch protein, which result in an active form of the receptor." [PMID:12651094, PMID:14986688]
synonym: "N receptor processing" EXACT []
xref: Reactome:REACT_106849 "Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor, Mus musculus"
xref: Reactome:REACT_108234 "A third proteolytic cleavage releases NICD, Xenopus tropicalis"
xref: Reactome:REACT_109903 "Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor, Xenopus tropicalis"
xref: Reactome:REACT_2001 "Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor, Homo sapiens"
xref: Reactome:REACT_31981 "A third proteolytic cleavage releases NICD, Drosophila melanogaster"
xref: Reactome:REACT_33277 "Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor, Taeniopygia guttata"
xref: Reactome:REACT_691 "A third proteolytic cleavage releases NICD, Homo sapiens"
xref: Reactome:REACT_77097 "A third proteolytic cleavage releases NICD, Sus scrofa"
xref: Reactome:REACT_77321 "A third proteolytic cleavage releases NICD, Bos taurus"
xref: Reactome:REACT_79066 "Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor, Sus scrofa"
xref: Reactome:REACT_82022 "Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor, Bos taurus"
xref: Reactome:REACT_82265 "A third proteolytic cleavage releases NICD, Taeniopygia guttata"
xref: Reactome:REACT_83513 "A third proteolytic cleavage releases NICD, Canis familiaris"
xref: Reactome:REACT_88941 "A third proteolytic cleavage releases NICD, Gallus gallus"
xref: Reactome:REACT_89759 "Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor, Rattus norvegicus"
xref: Reactome:REACT_91812 "Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor, Drosophila melanogaster"
xref: Reactome:REACT_92471 "Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor, Canis familiaris"
xref: Reactome:REACT_93612 "Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor, Gallus gallus"
xref: Reactome:REACT_95551 "A third proteolytic cleavage releases NICD, Danio rerio"
xref: Reactome:REACT_96861 "A third proteolytic cleavage releases NICD, Rattus norvegicus"
xref: Reactome:REACT_98889 "Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor, Danio rerio"
xref: Reactome:REACT_99294 "A third proteolytic cleavage releases NICD, Mus musculus"
is_a: GO:0044267 ! cellular protein metabolic process

[Term]
id: GO:0007221
name: positive regulation of transcription of Notch receptor target
namespace: biological_process
def: "The activation of transcription of specific genes as a result of Notch signaling, mediated by the Notch intracellular domain." [PMID:12651094]
synonym: "N receptor target transcription factor activation" RELATED []
synonym: "Notch receptor target transcription factor activation" RELATED []
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
relationship: part_of GO:0007219 ! Notch signaling pathway

[Term]
id: GO:0007223
name: Wnt signaling pathway, calcium modulating pathway
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC)." [GOC:bf, GOC:dph, GOC:go_curators, PMID:11532397]
synonym: "frizzled-2 signaling pathway" NARROW []
synonym: "frizzled-2 signalling pathway" NARROW []
synonym: "non-canonical Wnt signaling pathway" RELATED []
synonym: "Wnt receptor signaling pathway, calcium modulating pathway" EXACT []
synonym: "Wnt-activated signaling pathway, calcium modulating pathway" EXACT [GOC:signaling]
is_a: GO:0035567 ! non-canonical Wnt signaling pathway

[Term]
id: GO:0007224
name: smoothened signaling pathway
namespace: biological_process
def: "A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened." [GOC:mah, PMID:15205520]
synonym: "hedgehog signaling pathway" EXACT []
synonym: "hh signaling pathway" NARROW []
synonym: "hh signalling pathway" NARROW []
synonym: "Shh signaling pathway" RELATED [GOC:dph]
synonym: "smoothened signalling pathway" EXACT []
synonym: "Sonic hedgehog signaling pathway" NARROW [GOC:dph]
xref: Wikipedia:Hedgehog_signaling_pathway
is_a: GO:0007166 ! cell surface receptor signaling pathway

[Term]
id: GO:0007225
name: patched ligand maturation
namespace: biological_process
def: "The posttranslational modification of members of the Hedgehog family of signaling proteins in order for Hedgehog to exert its biological activity. These modifications include cleavage of its signal sequence, autocatalytic protein cleavage and the attachment of sterol groups." [PMID:15057936]
synonym: "Hedgehog protein processing" NARROW []
synonym: "hh protein processing" EXACT []
synonym: "patched ligand processing" RELATED []
is_a: GO:0035638 ! signal maturation
is_a: GO:0044710 ! single-organism metabolic process
is_a: GO:0051604 ! protein maturation
relationship: part_of GO:0045880 ! positive regulation of smoothened signaling pathway

[Term]
id: GO:0007227
name: signal transduction downstream of smoothened
namespace: biological_process
def: "The series of molecular signals that are initiated by the transmembrane protein Smoothened. In the presence of a Hedgehog signaling molecule, the Patched protein no longer inhibits the activity of Smoothened, and Smoothened signals via the Hedgehog signaling complex to activate downstream components of the Hedgehog signaling pathway." [PMID:15057936]
is_a: GO:0035556 ! intracellular signal transduction
relationship: part_of GO:0007224 ! smoothened signaling pathway

[Term]
id: GO:0007228
name: positive regulation of hh target transcription factor activity
namespace: biological_process
def: "Any process that increases the activity of a transcription factor that activates transcription of Hedgehog-target genes in response to Smoothened signaling. In Drosophila, Cubitus interruptus (Ci) is the only identified transcription factor so far in the Hedgehog signaling pathway. In vertebrates, members of the Gli protein family are activated in this way. Activation of the Gli/Ci transcription factor is distinct from its stabilization, when proteolytic cleavage is inhibited." [GOC:dph, GOC:tb, PMID:11912487, PMID:15057936]
synonym: "activation of hh target transcription factor" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of hedgehog target transcription factor" EXACT [GOC:bf, GOC:ecd]
is_a: GO:0051091 ! positive regulation of sequence-specific DNA binding transcription factor activity
relationship: part_of GO:0007227 ! signal transduction downstream of smoothened

[Term]
id: GO:0007229
name: integrin-mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling]
synonym: "integrin-mediated signalling pathway" EXACT []
is_a: GO:0007166 ! cell surface receptor signaling pathway

[Term]
id: GO:0007230
name: obsolete calcium-o-sensing receptor pathway
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it does not make sense.
synonym: "calcium-o-sensing receptor pathway" EXACT []
is_obsolete: true
consider: GO:0019722

[Term]
id: GO:0007231
name: osmosensory signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated in response to osmotic change." [GOC:jl]
subset: gosubset_prok
synonym: "osmolarity sensing" EXACT []
synonym: "osmolarity sensing signaling pathway" EXACT []
synonym: "osmolarity sensing signalling pathway" EXACT []
synonym: "osmosensory signal transduction" EXACT [GOC:signaling]
synonym: "osmosensory signalling pathway" EXACT []
synonym: "signal transduction during osmotic stress" EXACT []
is_a: GO:0007165 ! signal transduction
is_a: GO:0071470 ! cellular response to osmotic stress

[Term]
id: GO:0007232
name: osmosensory signaling pathway via Sho1 osmosensor
namespace: biological_process
def: "A series of molecular signals generated in response to osmotic change, as mediated through a Sho1 osmosensor system." [GOC:jl]
synonym: "osmosensory signalling pathway via Sho1 osmosensor" EXACT []
synonym: "signal transduction during osmotic stress via Sho1 osmosensor" EXACT []
is_a: GO:0007231 ! osmosensory signaling pathway

[Term]
id: GO:0007234
name: osmosensory signaling via phosphorelay pathway
namespace: biological_process
def: "A series of molecular signals generated in response to osmotic change, as mediated through a phosphorelay system." [PMID:9843501]
subset: gosubset_prok
synonym: "osmolarity sensing via two-component system" EXACT []
synonym: "osmolarity signaling pathway via two-component system" EXACT []
synonym: "osmolarity signalling pathway via two-component system" EXACT []
synonym: "osmosensory signaling pathway via two-component system" NARROW []
synonym: "osmosensory signalling pathway via two-component system" EXACT []
synonym: "signal transduction during osmotic stress via two-component system" EXACT []
is_a: GO:0000160 ! phosphorelay signal transduction system
is_a: GO:0007231 ! osmosensory signaling pathway

[Term]
id: GO:0007235
name: obsolete activation of Ypd1 protein
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it contains gene product and species specific information.
synonym: "activation of Ypd1 protein" EXACT []
is_obsolete: true

[Term]
id: GO:0007236
name: obsolete activation of Ssk1 protein
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it contains gene product and species specific information.
synonym: "activation of Ssk1 protein" EXACT []
is_obsolete: true

[Term]
id: GO:0007237
name: obsolete activation of Ssk2/Ssk22 proteins
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it contains gene product and species specific information.
synonym: "activation of Ssk2/Ssk22 proteins" EXACT []
is_obsolete: true

[Term]
id: GO:0007238
name: obsolete activation of Pbs2
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it contains gene product and species specific information.
synonym: "activation of Pbs2" EXACT []
is_obsolete: true

[Term]
id: GO:0007239
name: obsolete activation of Hog1
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it contains gene product and species specific information.
synonym: "activation of Hog1" EXACT []
is_obsolete: true

[Term]
id: GO:0007240
name: obsolete nuclear translocation of Hog1
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it contains gene product and species specific information.
synonym: "nuclear translocation of Hog1" EXACT []
is_obsolete: true

[Term]
id: GO:0007241
name: obsolete inactivation of Hog1
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it contains gene product and species specific information.
synonym: "inactivation of Hog1" EXACT []
is_obsolete: true

[Term]
id: GO:0007244
name: obsolete MAPKKK cascade (mating sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. MAPKKK cascade involved in transduction of mating pheromone signal, as described in Saccharomyces." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "MAPKKK cascade (mating sensu Saccharomyces)" EXACT []
is_obsolete: true
replaced_by: GO:0000750

[Term]
id: GO:0007245
name: obsolete activation of MAPKKK (mating sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. Upregulation of MAPKKK activity in the context of transduction of mating pheromone signal, as described for Saccharomyces." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "activation of MAPKKK (mating sensu Saccharomyces)" EXACT []
is_obsolete: true
replaced_by: GO:0000750

[Term]
id: GO:0007246
name: obsolete activation of MAPKK (mating sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. Upregulation of a MAP kinase kinase in the context of transduction of mating pheromone signal, as described for Saccharomyces." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "activation of MAPKK (mating sensu Saccharomyces)" EXACT []
is_obsolete: true
replaced_by: GO:0000750

[Term]
id: GO:0007247
name: obsolete activation of MAPK (mating sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. Upregulation of MAP kinase activity in the context of transduction of mating pheromone signal, as described for Saccharomyces." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "activation of MAPK (mating sensu Saccharomyces)" EXACT []
is_obsolete: true
consider: GO:0000750

[Term]
id: GO:0007248
name: obsolete nuclear translocation of MAPK (mating sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. Movement of a MAP kinase to the nucleus in the context of transduction of mating pheromone signal, as described for Saccharomyces." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "nuclear translocation of MAPK (mating sensu Saccharomyces)" EXACT []
is_obsolete: true
replaced_by: GO:0000750

[Term]
id: GO:0007249
name: I-kappaB kinase/NF-kappaB signaling
namespace: biological_process
def: "The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription." [GOC:bf, GOC:jl, PMID:12773372, Reactome:REACT_13696.1]
synonym: "activation of the inhibitor of kappa kinase" RELATED []
synonym: "canonical NF-kappaB signaling cascade" EXACT [GOC:bf]
synonym: "I-kappaB kinase/NF-kappaB cascade" RELATED [GOC:signaling]
synonym: "I-kappaB kinase/NF-kappaB signal transduction" EXACT [GOC:signaling]
synonym: "NF-kappaB cascade" BROAD []
synonym: "p50-dependent NF-kappaB signaling" RELATED [PMID:18292232]
xref: Reactome:REACT_13696.1 "NF-kB is activated and signals survival, Homo sapiens"
xref: Reactome:REACT_25351 "TRAF6 mediated induction of TAK1 complex, Homo sapiens"
is_a: GO:0035556 ! intracellular signal transduction
relationship: has_part GO:0051092 ! positive regulation of NF-kappaB transcription factor activity

[Term]
id: GO:0007250
name: activation of NF-kappaB-inducing kinase activity
namespace: biological_process
def: "The stimulation of the activity of NF-kappaB-inducing kinase through phosphorylation at specific residues." [GOC:jl, PMID:12773372]
synonym: "activation of NIK activity" EXACT [GOC:bf]
synonym: "positive regulation of NF-kappaB-inducing kinase activity" BROAD []
xref: Reactome:REACT_25145 "TAK1 activates NFkB by phosphorylation and activation of IKKs complex, Gallus gallus"
xref: Reactome:REACT_75885 "Caspase-8 and -10 mediated induction of NF-kB, Gallus gallus"
xref: Reactome:REACT_75895 "TRAF6 mediated NF-kB activation, Gallus gallus"
is_a: GO:0032147 ! activation of protein kinase activity
is_a: GO:0071902 ! positive regulation of protein serine/threonine kinase activity
is_a: GO:1901224 ! positive regulation of NIK/NF-kappaB signaling
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004704 ! NF-kappaB-inducing kinase activity
relationship: part_of GO:0038061 ! NIK/NF-kappaB signaling
relationship: positively_regulates GO:0004704 ! NF-kappaB-inducing kinase activity

[Term]
id: GO:0007251
name: obsolete activation of the inhibitor of kappa kinase
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because its meaning was unclear.
synonym: "activation of the inhibitor of kappa kinase" EXACT []
is_obsolete: true
consider: GO:0007249

[Term]
id: GO:0007252
name: I-kappaB phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription." [GOC:bf, GOC:jl, PMID:21772278, PMID:7594468]
synonym: "IkappaB phosphorylation" EXACT [GOC:bf]
synonym: "IKB phosphorylation" EXACT [GOC:bf]
synonym: "inhibitor of kappaB phosphorylation" EXACT [GOC:bf]
synonym: "inhibitor of NF-kappaB phosphorylation" EXACT [GOC:bf]
is_a: GO:0006468 ! protein phosphorylation
relationship: part_of GO:0007249 ! I-kappaB kinase/NF-kappaB signaling

[Term]
id: GO:0007253
name: cytoplasmic sequestering of NF-kappaB
namespace: biological_process
def: "The selective interaction of the transcription factor NF-kappaB with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus." [GOC:jl]
synonym: "cytoplasmic NF-kappaB retention" EXACT []
synonym: "cytoplasmic NF-kappaB sequestration" EXACT []
synonym: "cytoplasmic NF-kappaB storage" EXACT []
synonym: "cytoplasmic retention of NF-kappaB" EXACT []
synonym: "cytoplasmic sequestration of NF-kappaB" EXACT []
synonym: "cytoplasmic storage of NF-kappaB" EXACT []
synonym: "maintenance of NF-kappaB location in cytoplasm" EXACT [GOC:dph, GOC:tb]
is_a: GO:0042347 ! negative regulation of NF-kappaB import into nucleus
is_a: GO:0042994 ! cytoplasmic sequestering of transcription factor
relationship: part_of GO:0043124 ! negative regulation of I-kappaB kinase/NF-kappaB signaling

[Term]
id: GO:0007254
name: JNK cascade
namespace: biological_process
def: "An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell." [GOC:bf, GOC:signaling, PMID:11790549, PMID:20811974]
synonym: "c-Jun N-terminal kinase cascade" EXACT [PMID:20811974]
synonym: "JNK1 cascade" NARROW [GOC:add]
synonym: "JNK2 cascade" NARROW [GOC:add]
synonym: "JNK3 cascade" NARROW [GOC:add]
synonym: "MAPK10 cascade" NARROW [GOC:add]
synonym: "MAPK8 cascade" NARROW [GOC:add]
synonym: "MAPK9 cascade" NARROW [GOC:add]
synonym: "SAPK cascade" BROAD []
synonym: "stress-activated protein kinase cascade" BROAD []
xref: Reactome:REACT_107073 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, Danio rerio"
xref: Reactome:REACT_107433 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, Taeniopygia guttata"
xref: Reactome:REACT_112172 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, Arabidopsis thaliana"
xref: Reactome:REACT_114741 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, Oryza sativa"
xref: Reactome:REACT_114745 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, Dictyostelium discoideum"
xref: Reactome:REACT_21368 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, Homo sapiens"
xref: Reactome:REACT_28804 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, Canis familiaris"
xref: Reactome:REACT_29903 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, Bos taurus"
xref: Reactome:REACT_29906 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, Mus musculus"
xref: Reactome:REACT_32441 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, Sus scrofa"
xref: Reactome:REACT_79447 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, Xenopus tropicalis"
xref: Reactome:REACT_87936 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, Gallus gallus"
xref: Reactome:REACT_89698 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, Rattus norvegicus"
xref: Reactome:REACT_95448 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, Caenorhabditis elegans"
is_a: GO:0051403 ! stress-activated MAPK cascade

[Term]
id: GO:0007256
name: activation of JNKK activity
namespace: biological_process
def: "The initiation of the activity of the inactive enzyme JUN kinase kinase (JNKK) activity. JNKKs are involved in a signaling pathway that is primarily activated by cytokines and exposure to environmental stress." [GOC:bf, PMID:11790549]
synonym: "activation of JUN kinase kinase activity" EXACT []
synonym: "positive regulation of JUNKK activity" BROAD []
is_a: GO:0000186 ! activation of MAPKK activity
is_a: GO:0043506 ! regulation of JUN kinase activity
is_a: GO:0046330 ! positive regulation of JNK cascade
relationship: part_of GO:0007254 ! JNK cascade
relationship: positively_regulates GO:0008545 ! JUN kinase kinase activity

[Term]
id: GO:0007257
name: activation of JUN kinase activity
namespace: biological_process
def: "The initiation of the activity of the inactive enzyme JUN kinase (JNK)." [GOC:bf]
synonym: "activation of SAPK activity" BROAD []
xref: Reactome:REACT_25273 "Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation, Gallus gallus"
is_a: GO:0000187 ! activation of MAPK activity
is_a: GO:0043507 ! positive regulation of JUN kinase activity
relationship: part_of GO:0007254 ! JNK cascade

[Term]
id: GO:0007258
name: JUN phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group into a JUN protein." [GOC:jl]
is_a: GO:0006468 ! protein phosphorylation
relationship: part_of GO:0007254 ! JNK cascade

[Term]
id: GO:0007259
name: JAK-STAT cascade
namespace: biological_process
def: "Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The JAK-STAT cascade begins with activation of STAT proteins by members of the JAK family of tyrosine kinases, proceeds through dimerization and subsequent nuclear translocation of STAT proteins, and ends with regulation of target gene expression by STAT proteins." [GOC:bf, GOC:jl, GOC:signaling, PMID:12039028]
synonym: "JAK-STAT signal transduction" EXACT [GOC:signaling]
xref: Wikipedia:JAK-STAT_signaling_pathway
is_a: GO:0097696 ! STAT cascade

[Term]
id: GO:0007260
name: tyrosine phosphorylation of STAT protein
namespace: biological_process
def: "The process of introducing a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:jl, PMID:10918594]
is_a: GO:0018108 ! peptidyl-tyrosine phosphorylation
relationship: part_of GO:0007259 ! JAK-STAT cascade

[Term]
id: GO:0007261
name: obsolete JAK-induced STAT protein dimerization
namespace: biological_process
def: "OBSOLETE. The formation of a dimer of two STAT proteins (Signal Transducers and Activators of Transcription) following their activation by members of the janus activated kinase (JAK) family of tyrosine kinases." [GOC:jl, PMID:12039028]
comment: This term was made obsolete because it is ambiguous, and protein dimerization is represented by molecular function terms.
synonym: "JAK-induced STAT protein dimerization" EXACT []
is_obsolete: true
consider: GO:0007260
consider: GO:0046983

[Term]
id: GO:0007262
name: STAT protein import into nucleus
namespace: biological_process
def: "The directed movement of dimerized STAT (Signal Transducers and Activators of Transcription) proteins into the nucleus following activation by members of the janus activated kinase (JAK) family of tyrosine kinases." [GOC:jl, PMID:12039028]
comment: Note that 'translocation' is sometimes used in the literature to refer to the entire process of protein import into the nucleus, but in GO refers specifically to the step in which a cargo-carrier protein complex moves through the nuclear pore complex.
synonym: "STAT protein nuclear translocation" NARROW [GOC:mah]
is_a: GO:0006606 ! protein import into nucleus
relationship: part_of GO:0007259 ! JAK-STAT cascade

[Term]
id: GO:0007263
name: nitric oxide mediated signal transduction
namespace: biological_process
def: "Any intracellular signal transduction in which the signal is passed on within the cell via nitric oxide (NO). Includes synthesis of nitric oxide, receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms." [GOC:jl, PMID:21549190]
synonym: "nitric oxide signaling" EXACT [GOC:bf]
synonym: "nitric oxide-mediated signal transduction" EXACT []
synonym: "NO mediated signal transduction" EXACT []
synonym: "NO-mediated signal transduction" EXACT []
is_a: GO:0019932 ! second-messenger-mediated signaling

[Term]
id: GO:0007264
name: small GTPase mediated signal transduction
namespace: biological_process
def: "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
subset: gosubset_prok
synonym: "small GTPase-mediated signal transduction" EXACT []
xref: Reactome:REACT_103736 "Signaling by Rho GTPases, Drosophila melanogaster"
xref: Reactome:REACT_104376 "Signalling to p38 via RIT and RIN, Canis familiaris"
xref: Reactome:REACT_104921 "Signaling by Rho GTPases, Sus scrofa"
xref: Reactome:REACT_107228 "Signaling by Rho GTPases, Caenorhabditis elegans"
xref: Reactome:REACT_107412 "Signalling to p38 via RIT and RIN, Saccharomyces cerevisiae"
xref: Reactome:REACT_108043 "Signalling to p38 via RIT and RIN, Danio rerio"
xref: Reactome:REACT_108899 "Signaling by Rho GTPases, Arabidopsis thaliana"
xref: Reactome:REACT_11044 "Signaling by Rho GTPases, Homo sapiens"
xref: Reactome:REACT_113091 "Signalling to p38 via RIT and RIN, Oryza sativa"
xref: Reactome:REACT_114399 "Signalling to p38 via RIT and RIN, Arabidopsis thaliana"
xref: Reactome:REACT_115149 "Signalling to p38 via RIT and RIN, Dictyostelium discoideum"
xref: Reactome:REACT_12077 "Signalling to p38 via RIT and RIN, Homo sapiens"
xref: Reactome:REACT_29744 "Signalling to p38 via RIT and RIN, Xenopus tropicalis"
xref: Reactome:REACT_30245 "Signaling by Rho GTPases, Rattus norvegicus"
xref: Reactome:REACT_30798 "Signalling to p38 via RIT and RIN, Schizosaccharomyces pombe"
xref: Reactome:REACT_32217 "Signaling by Rho GTPases, Gallus gallus"
xref: Reactome:REACT_33280 "Signalling to p38 via RIT and RIN, Taeniopygia guttata"
xref: Reactome:REACT_42108 "Signalling to p38 via RIT and RIN, Caenorhabditis elegans"
xref: Reactome:REACT_77454 "Signaling by Rho GTPases, Mus musculus"
xref: Reactome:REACT_77940 "Signalling to p38 via RIT and RIN, Drosophila melanogaster"
xref: Reactome:REACT_77969 "Signalling to p38 via RIT and RIN, Sus scrofa"
xref: Reactome:REACT_82274 "Signalling to p38 via RIT and RIN, Bos taurus"
xref: Reactome:REACT_85042 "Signaling by Rho GTPases, Saccharomyces cerevisiae"
xref: Reactome:REACT_85386 "Signaling by Rho GTPases, Schizosaccharomyces pombe"
xref: Reactome:REACT_85575 "Signaling by Rho GTPases, Taeniopygia guttata"
xref: Reactome:REACT_85886 "Signaling by Rho GTPases, Dictyostelium discoideum"
xref: Reactome:REACT_86435 "Signaling by Rho GTPases, Xenopus tropicalis"
xref: Reactome:REACT_88164 "Signaling by Rho GTPases, Canis familiaris"
xref: Reactome:REACT_90015 "Signalling to p38 via RIT and RIN, Gallus gallus"
xref: Reactome:REACT_90246 "Signaling by Rho GTPases, Danio rerio"
xref: Reactome:REACT_91397 "Signaling by Rho GTPases, Oryza sativa"
xref: Reactome:REACT_93599 "Signalling to p38 via RIT and RIN, Rattus norvegicus"
xref: Reactome:REACT_94830 "Signaling by Rho GTPases, Bos taurus"
xref: Reactome:REACT_96351 "Signalling to p38 via RIT and RIN, Mus musculus"
is_a: GO:0035556 ! intracellular signal transduction

[Term]
id: GO:0007265
name: Ras protein signal transduction
namespace: biological_process
def: "A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state." [GOC:bf]
synonym: "Ras mediated signal transduction" EXACT []
xref: Reactome:REACT_100282 "Signalling to RAS, Saccharomyces cerevisiae"
xref: Reactome:REACT_100832 "Signalling to RAS, Sus scrofa"
xref: Reactome:REACT_102992 "Signalling to RAS, Schizosaccharomyces pombe"
xref: Reactome:REACT_109099 "Signalling to RAS, Gallus gallus"
xref: Reactome:REACT_114204 "Signalling to RAS, Oryza sativa"
xref: Reactome:REACT_114859 "Signalling to RAS, Arabidopsis thaliana"
xref: Reactome:REACT_115010 "Signalling to RAS, Dictyostelium discoideum"
xref: Reactome:REACT_12033 "Signalling to RAS, Homo sapiens"
xref: Reactome:REACT_31921 "Signalling to RAS, Danio rerio"
xref: Reactome:REACT_78554 "Signalling to RAS, Rattus norvegicus"
xref: Reactome:REACT_79426 "Signalling to RAS, Drosophila melanogaster"
xref: Reactome:REACT_79898 "Signalling to RAS, Xenopus tropicalis"
xref: Reactome:REACT_81747 "Signalling to RAS, Caenorhabditis elegans"
xref: Reactome:REACT_82585 "Signalling to RAS, Bos taurus"
xref: Reactome:REACT_89778 "Signalling to RAS, Mus musculus"
xref: Reactome:REACT_93180 "Signalling to RAS, Taeniopygia guttata"
xref: Reactome:REACT_97052 "Signalling to RAS, Canis familiaris"
is_a: GO:0007264 ! small GTPase mediated signal transduction

[Term]
id: GO:0007266
name: Rho protein signal transduction
namespace: biological_process
def: "A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state." [GOC:bf]
synonym: "Rho mediated signal transduction" EXACT []
is_a: GO:0007265 ! Ras protein signal transduction

[Term]
id: GO:0007267
name: cell-cell signaling
namespace: biological_process
def: "Any process that mediates the transfer of information from one cell to another." [GOC:mah]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_plant
subset: gosubset_prok
synonym: "cell-cell signalling" EXACT []
is_a: GO:0007154 ! cell communication
is_a: GO:0044700 ! single organism signaling

[Term]
id: GO:0007268
name: synaptic transmission
namespace: biological_process
def: "The vesicular release of classical neurotransmitter molecules from a neuron, across a chemical synapse, the subsequent activation of neurotransmitter receptors of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:jl, MeSH:D009435]
subset: goslim_synapse
synonym: "neurotransmission" RELATED [GOC:dph]
synonym: "signal transmission across a synapse" BROAD []
synonym: "synaptic transmission" BROAD []
xref: Reactome:REACT_102443 "Transmission across Chemical Synapses, Mycobacterium tuberculosis"
xref: Reactome:REACT_102748 "Neuronal System, Saccharomyces cerevisiae"
xref: Reactome:REACT_102963 "Transmission across Chemical Synapses, Canis familiaris"
xref: Reactome:REACT_104470 "Transmission across Chemical Synapses, Rattus norvegicus"
xref: Reactome:REACT_104894 "Neuronal System, Xenopus tropicalis"
xref: Reactome:REACT_105301 "Transmission across Chemical Synapses, Caenorhabditis elegans"
xref: Reactome:REACT_106168 "Transmission across Chemical Synapses, Escherichia coli"
xref: Reactome:REACT_106459 "Transmission across Chemical Synapses, Mus musculus"
xref: Reactome:REACT_107151 "Neuronal System, Sus scrofa"
xref: Reactome:REACT_107221 "Transmission across Chemical Synapses, Schizosaccharomyces pombe"
xref: Reactome:REACT_112265 "Transmission across Chemical Synapses, Staphylococcus aureus N315"
xref: Reactome:REACT_113444 "Neuronal System, Staphylococcus aureus N315"
xref: Reactome:REACT_13477 "Transmission across Chemical Synapses, Homo sapiens"
xref: Reactome:REACT_13685 "Neuronal System, Homo sapiens"
xref: Reactome:REACT_29254 "Neuronal System, Danio rerio"
xref: Reactome:REACT_29595 "Neuronal System, Caenorhabditis elegans"
xref: Reactome:REACT_29683 "Transmission across Chemical Synapses, Drosophila melanogaster"
xref: Reactome:REACT_30050 "Transmission across Chemical Synapses, Gallus gallus"
xref: Reactome:REACT_30266 "Transmission across Chemical Synapses, Sus scrofa"
xref: Reactome:REACT_31284 "Transmission across Chemical Synapses, Saccharomyces cerevisiae"
xref: Reactome:REACT_33322 "Neuronal System, Taeniopygia guttata"
xref: Reactome:REACT_33434 "Neuronal System, Escherichia coli"
xref: Reactome:REACT_78038 "Neuronal System, Rattus norvegicus"
xref: Reactome:REACT_78840 "Transmission across Chemical Synapses, Taeniopygia guttata"
xref: Reactome:REACT_79078 "Transmission across Chemical Synapses, Arabidopsis thaliana"
xref: Reactome:REACT_80052 "Neuronal System, Schizosaccharomyces pombe"
xref: Reactome:REACT_82334 "Transmission across Chemical Synapses, Bos taurus"
xref: Reactome:REACT_82746 "Neuronal System, Arabidopsis thaliana"
xref: Reactome:REACT_86563 "Neuronal System, Mus musculus"
xref: Reactome:REACT_86628 "Neuronal System, Canis familiaris"
xref: Reactome:REACT_88599 "Neuronal System, Bos taurus"
xref: Reactome:REACT_88891 "Neuronal System, Mycobacterium tuberculosis"
xref: Reactome:REACT_89065 "Neuronal System, Gallus gallus"
xref: Reactome:REACT_89149 "Neuronal System, Dictyostelium discoideum"
xref: Reactome:REACT_89785 "Neuronal System, Drosophila melanogaster"
xref: Reactome:REACT_90781 "Transmission across Chemical Synapses, Danio rerio"
xref: Reactome:REACT_93592 "Transmission across Chemical Synapses, Xenopus tropicalis"
xref: Reactome:REACT_98546 "Transmission across Chemical Synapses, Dictyostelium discoideum"
xref: Reactome:REACT_99535 "Transmission across Chemical Synapses, Oryza sativa"
xref: Reactome:REACT_99952 "Neuronal System, Oryza sativa"
xref: Wikipedia:Neurotransmission
is_a: GO:0098916 ! anterograde trans-synaptic signaling

[Term]
id: GO:0007269
name: neurotransmitter secretion
namespace: biological_process
alt_id: GO:0010554
def: "The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium regualated exocytosis during synaptic transmission." [CHEBI:25512, GOC:dph]
comment: A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin.
subset: goslim_synapse
synonym: "neurotransmitter release" EXACT []
synonym: "neurotransmitter secretory pathway" EXACT []
xref: Reactome:REACT_100716 "Neurotransmitter Release Cycle, Bos taurus"
xref: Reactome:REACT_102134 "Neurotransmitter Release Cycle, Arabidopsis thaliana"
xref: Reactome:REACT_102586 "Neurotransmitter Release Cycle, Xenopus tropicalis"
xref: Reactome:REACT_102743 "Neurotransmitter Release Cycle, Rattus norvegicus"
xref: Reactome:REACT_105010 "Neurotransmitter Release Cycle, Oryza sativa"
xref: Reactome:REACT_105885 "Neurotransmitter Release Cycle, Taeniopygia guttata"
xref: Reactome:REACT_110862 "Neurotransmitter Release Cycle, Sus scrofa"
xref: Reactome:REACT_11184 "Botulinum neurotoxicity, Homo sapiens"
xref: Reactome:REACT_113329 "Neurotransmitter Release Cycle, Staphylococcus aureus N315"
xref: Reactome:REACT_115061 "Neurotransmitter Release Cycle, Dictyostelium discoideum"
xref: Reactome:REACT_13723 "Neurotransmitter Release Cycle, Homo sapiens"
xref: Reactome:REACT_29477 "Neurotransmitter Release Cycle, Danio rerio"
xref: Reactome:REACT_29495 "Neurotransmitter Release Cycle, Drosophila melanogaster"
xref: Reactome:REACT_29928 "Neurotransmitter Release Cycle, Mus musculus"
xref: Reactome:REACT_77375 "Neurotransmitter Release Cycle, Mycobacterium tuberculosis"
xref: Reactome:REACT_85993 "Neurotransmitter Release Cycle, Canis familiaris"
xref: Reactome:REACT_91316 "Neurotransmitter Release Cycle, Caenorhabditis elegans"
xref: Reactome:REACT_95406 "Neurotransmitter Release Cycle, Gallus gallus"
xref: Reactome:REACT_99398 "Neurotransmitter Release Cycle, Escherichia coli"
is_a: GO:0001505 ! regulation of neurotransmitter levels
is_a: GO:0006836 ! neurotransmitter transport
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0099531 ! presynaptic process involved in synaptic transmission
is_a: GO:0099643 ! signal release from synapse
relationship: occurs_in GO:0098793 ! presynapse
relationship: part_of GO:0007268 ! synaptic transmission

[Term]
id: GO:0007270
name: neuron-neuron synaptic transmission
namespace: biological_process
def: "The process of communication from a neuron to another neuron across a synapse." [GOC:add, GOC:jl, MeSH:D009435]
synonym: "nerve-nerve synaptic transmission" RELATED []
is_a: GO:0007268 ! synaptic transmission

[Term]
id: GO:0007271
name: synaptic transmission, cholinergic
namespace: biological_process
def: "The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse using the neurotransmitter acetylcholine." [GOC:kmv, GOC:pr, Wikipedia:Cholinergic]
is_a: GO:0007268 ! synaptic transmission

[Term]
id: GO:0007272
name: ensheathment of neurons
namespace: biological_process
def: "The process in which glial cells envelop neuronal cell bodies and/or axons to form an insulating layer. This can take the form of myelinating or non-myelinating ensheathment." [GOC:dgh, GOC:dph, GOC:tb]
synonym: "ionic insulation of neurons by glial cells" RELATED []
is_a: GO:0044763 ! single-organism cellular process
relationship: part_of GO:0007399 ! nervous system development

[Term]
id: GO:0007273
name: obsolete regulation of synapse
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because the term string made no sense.
synonym: "regulation of synapse" EXACT []
is_obsolete: true
consider: GO:0007268

[Term]
id: GO:0007274
name: neuromuscular synaptic transmission
namespace: biological_process
def: "The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435]
is_a: GO:0007268 ! synaptic transmission

[Term]
id: GO:0007275
name: multicellular organism development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
comment: Note that this term was 'developmental process'.
subset: goslim_chembl
subset: goslim_plant
is_a: GO:0044707 ! single-multicellular organism process
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development

[Term]
id: GO:0007276
name: gamete generation
namespace: biological_process
alt_id: GO:0009552
def: "The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell." [GOC:ems, GOC:mtg_sensu]
synonym: "gametogenesis" RELATED []
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0048609 ! multicellular organismal reproductive process
relationship: part_of GO:0019953 ! sexual reproduction

[Term]
id: GO:0007277
name: pole cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pole cell over time, from its formation to the mature structure." [GOC:jid]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0048468 ! cell development
relationship: part_of GO:0007276 ! gamete generation

[Term]
id: GO:0007278
name: pole cell fate determination
namespace: biological_process
def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a pole cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators]
is_a: GO:0001709 ! cell fate determination
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
relationship: part_of GO:0007277 ! pole cell development

[Term]
id: GO:0007279
name: pole cell formation
namespace: biological_process
def: "Formation of a small group of cells (pole cells) at the posterior pole of the insect blastula. They are the first cells to cellularize after the arrival of nuclei at the end of the syncytial blastula stage and are the precursors to the insect germ cells." [GOC:bf, PMID:9988212]
comment: See also the Cell Ontology term 'pole cell ; CL:0000301'.
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0007349 ! cellularization
is_a: GO:0044702 ! single organism reproductive process
relationship: part_of GO:0007277 ! pole cell development

[Term]
id: GO:0007280
name: pole cell migration
namespace: biological_process
def: "The directed movement of a pole cell (germline progenitors in insects) from its site of production at the posterior pole of the embryo through to the site where the gonads will form." [GOC:bf, PMID:9988212]
comment: See also the Cell Ontology term 'pole cell ; CL:0000301'.
is_a: GO:0008354 ! germ cell migration

[Term]
id: GO:0007281
name: germ cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators]
synonym: "germ-cell development" EXACT []
synonym: "primordial germ cell development" NARROW []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0048468 ! cell development
relationship: part_of GO:0007276 ! gamete generation

[Term]
id: GO:0007282
name: cystoblast division
namespace: biological_process
def: "Any of the rounds of incomplete mitosis undergone by a cystoblast to form a cyst of interconnected cells." [PMID:21452446]
synonym: "cystoblast cell division" EXACT []
is_a: GO:0008356 ! asymmetric cell division
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
relationship: part_of GO:0007281 ! germ cell development

[Term]
id: GO:0007283
name: spermatogenesis
namespace: biological_process
def: "The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846]
synonym: "generation of spermatozoa" EXACT systematic_synonym []
xref: Wikipedia:Spermatogenesis
is_a: GO:0048232 ! male gamete generation

[Term]
id: GO:0007284
name: spermatogonial cell division
namespace: biological_process
def: "The mitotic divisions of the primary spermatogonial cell (a primordial male germ cell) to form secondary spermatogonia (primary spermatocytes)." [GOC:bf, GOC:pr, ISBN:0879694238]
comment: See also the Cell Ontology terms 'spermatogonium ; CL:0000020' and 'primary spermatocyte ; CL:0000656'.
synonym: "spermatogonium division" EXACT []
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0051301 ! cell division
relationship: part_of GO:0007283 ! spermatogenesis

[Term]
id: GO:0007285
name: primary spermatocyte growth
namespace: biological_process
def: "The phase of growth and gene expression that male germ cells undergo as they enter the spermatocyte stage. The cells grow in volume and transcribe most of the gene products needed for the morphological events that follow meiosis." [GOC:jid, ISBN:0879694238]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0048588 ! developmental cell growth
relationship: part_of GO:0007283 ! spermatogenesis

[Term]
id: GO:0007286
name: spermatid development
namespace: biological_process
def: "The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators]
synonym: "spermatid cell development" EXACT []
synonym: "spermiogenesis" EXACT []
xref: Wikipedia:Spermiogenesis
is_a: GO:0007281 ! germ cell development
relationship: part_of GO:0048515 ! spermatid differentiation

[Term]
id: GO:0007287
name: Nebenkern assembly
namespace: biological_process
def: "Fusion of mitochondria during insect spermatid differentiation to form two masses, which wrap around each other to form a densely packed sphere called the Nebenkern." [GOC:bf, ISBN:0879694238]
comment: See also the cellular component term 'Nebenkern ; GO:0016006', and the fly_anatomy.ontology term 'Nebenkern ; FBbt:00004943'.
synonym: "nebenkern assembly" EXACT [PMID:9550716]
synonym: "Nebenkern formation" RELATED [GOC:dph]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0007005 ! mitochondrion organization
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0070925 ! organelle assembly
is_a: GO:1902589 ! single-organism organelle organization
relationship: part_of GO:0007286 ! spermatid development

[Term]
id: GO:0007288
name: sperm axoneme assembly
namespace: biological_process
def: "The assembly and organization of the sperm flagellar axoneme, the bundle of microtubules and associated proteins that forms the core of the eukaryotic sperm flagellum, and is responsible for movement." [GOC:bf, ISBN:0198547684]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0035082 ! axoneme assembly
relationship: part_of GO:0007286 ! spermatid development

[Term]
id: GO:0007289
name: spermatid nucleus differentiation
namespace: biological_process
def: "The specialization of the spermatid nucleus during the development of a spermatid into a mature male gamete competent for fertilization." [GOC:bf, GOC:dph, GOC:jl, GOC:mah]
comment: See also the Cell Ontology term 'spermatid ; CL:0000018'.
synonym: "spermatid nuclear differentiation" EXACT []
is_a: GO:0006997 ! nucleus organization
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:1902589 ! single-organism organelle organization
relationship: part_of GO:0007286 ! spermatid development

[Term]
id: GO:0007290
name: spermatid nucleus elongation
namespace: biological_process
def: "The change in shape of the spermatid nucleus from a spherical structure to an elongated organelle, during the latter part of spermatid differentiation." [GOC:bf, GOC:dph, GOC:jl, GOC:mah, ISBN:0879694238]
synonym: "spermatid nuclear elongation" EXACT []
is_a: GO:0006997 ! nucleus organization
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:1902589 ! single-organism organelle organization
relationship: part_of GO:0007289 ! spermatid nucleus differentiation

[Term]
id: GO:0007291
name: sperm individualization
namespace: biological_process
def: "The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0007349 ! cellularization
is_a: GO:0044702 ! single organism reproductive process
relationship: part_of GO:0007286 ! spermatid development

[Term]
id: GO:0007292
name: female gamete generation
namespace: biological_process
def: "Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction." [GOC:dph, ISBN:0198506732]
is_a: GO:0007276 ! gamete generation

[Term]
id: GO:0007293
name: germarium-derived egg chamber formation
namespace: biological_process
def: "Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0048477 ! oogenesis

[Term]
id: GO:0007294
name: germarium-derived oocyte fate determination
namespace: biological_process
alt_id: GO:0016350
def: "The cell fate determination process in which a germarium-derived cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
synonym: "maintenance of oocyte identity" RELATED []
synonym: "oocyte cell fate determination" RELATED []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0030716 ! oocyte fate determination
relationship: part_of GO:0030706 ! germarium-derived oocyte differentiation

[Term]
id: GO:0007295
name: growth of a germarium-derived egg chamber
namespace: biological_process
def: "Growth of the egg chamber between the time it leaves the germarium and the onset of vitellogenesis. During this time both nurse cells and the oocyte undergo developmental changes including nuclear organization and cytoplasmic growth. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
synonym: "egg chamber growth" EXACT []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0048589 ! developmental growth
relationship: part_of GO:0048477 ! oogenesis

[Term]
id: GO:0007296
name: vitellogenesis
namespace: biological_process
def: "The production of yolk. Yolk is a mixture of materials used for embryonic nutrition." [GOC:dph, ISBN:0879694238]
synonym: "yolk production" EXACT systematic_synonym []
xref: Wikipedia:Vitellogenesis
is_a: GO:0007028 ! cytoplasm organization
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
relationship: part_of GO:0007292 ! female gamete generation

[Term]
id: GO:0007297
name: ovarian follicle cell migration
namespace: biological_process
def: "The directed movement of an ovarian follicle cell that takes place during oogenesis. During egg chamber formation, follicle cells migrate to envelop the germ-line cysts and move in between cysts. At stage 10B, follicle cells migrate centripetally between the nurse cells and the oocyte, enclosing the anterior of the egg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
synonym: "follicle cell migration" BROAD []
is_a: GO:0010631 ! epithelial cell migration
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
relationship: part_of GO:0030707 ! ovarian follicle cell development

[Term]
id: GO:0007298
name: border follicle cell migration
namespace: biological_process
def: "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
synonym: "border cell migration" BROAD []
is_a: GO:0007297 ! ovarian follicle cell migration

[Term]
id: GO:0007299
name: ovarian follicle cell-cell adhesion
namespace: biological_process
def: "The attachment of a somatic follicle cell to another somatic follicle cell or to its substratum, the germline cells. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12642496]
synonym: "follicle cell adhesion" BROAD []
synonym: "ovarian follicle cell adhesion" EXACT [GOC:curators]
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0090136 ! epithelial cell-cell adhesion
relationship: part_of GO:0030707 ! ovarian follicle cell development

[Term]
id: GO:0007300
name: ovarian nurse cell to oocyte transport
namespace: biological_process
def: "Transfer of constituents synthesized in the ovarian nurse cells to the oocyte, through the ring canals, as the egg chamber is growing. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
synonym: "nurse cell to oocyte transport" BROAD []
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0044765 ! single-organism transport
relationship: part_of GO:0048477 ! oogenesis

[Term]
id: GO:0007301
name: female germline ring canal formation
namespace: biological_process
def: "Assembly of the intercellular bridges that connect the germ-line cells of a female cyst." [ISBN:0879694238]
synonym: "nurse cell ring canal formation" NARROW []
synonym: "ovarian ring canal formation" NARROW []
is_a: GO:0030725 ! germline ring canal formation
relationship: part_of GO:0007293 ! germarium-derived egg chamber formation
relationship: part_of GO:0007300 ! ovarian nurse cell to oocyte transport

[Term]
id: GO:0007302
name: nurse cell nucleus anchoring
namespace: biological_process
def: "Attachment of the nurse cell nucleus to the plasma membrane." [ISBN:0879694238]
is_a: GO:0022414 ! reproductive process
is_a: GO:0022610 ! biological adhesion
relationship: part_of GO:0007300 ! ovarian nurse cell to oocyte transport

[Term]
id: GO:0007303
name: cytoplasmic transport, nurse cell to oocyte
namespace: biological_process
def: "The directed movement of cytoplasmic constituents synthesized in the nurse cells to the oocyte." [ISBN:0879694238]
is_a: GO:0016482 ! cytosolic transport
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:1902582 ! single-organism intracellular transport
relationship: part_of GO:0007300 ! ovarian nurse cell to oocyte transport

[Term]
id: GO:0007304
name: chorion-containing eggshell formation
namespace: biological_process
def: "The construction of a chorion-containing eggshell. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
synonym: "eggshell formation" BROAD []
is_a: GO:0030703 ! eggshell formation
relationship: part_of GO:0030707 ! ovarian follicle cell development

[Term]
id: GO:0007305
name: vitelline membrane formation involved in chorion-containing eggshell formation
namespace: biological_process
def: "Construction of the vitelline membrane portion of a chorion-containing eggshell. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
synonym: "vitelline membrane formation in chorion-containing eggshell" EXACT [GOC:dph, GOC:tb]
is_a: GO:0030704 ! vitelline membrane formation
intersection_of: GO:0030704 ! vitelline membrane formation
intersection_of: part_of GO:0007304 ! chorion-containing eggshell formation
relationship: part_of GO:0007304 ! chorion-containing eggshell formation

[Term]
id: GO:0007306
name: eggshell chorion assembly
namespace: biological_process
def: "Construction of the chorion portion of the eggshell, which comprises the channels for gas exchange in an insect eggshell." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238]
synonym: "eggshell chorion formation" EXACT [GOC:dph, GOC:tb]
synonym: "insect chorion formation" RELATED []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
relationship: part_of GO:0007304 ! chorion-containing eggshell formation

[Term]
id: GO:0007307
name: eggshell chorion gene amplification
namespace: biological_process
def: "Amplification by up to 60-fold of the loci containing the chorion gene clusters. Amplification is necessary for the rapid synthesis of chorion proteins by the follicle cells, and occurs by repeated firing of one or more origins located within each gene cluster." [GOC:mtg_sensu, PMID:11157771]
is_a: GO:0006277 ! DNA amplification
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0044711 ! single-organism biosynthetic process
relationship: part_of GO:0007306 ! eggshell chorion assembly

[Term]
id: GO:0007308
name: oocyte construction
namespace: biological_process
alt_id: GO:0048110
def: "The synthesis, deposition, and organization of the materials in a cell of an ovary; where the cell can then undergo meiosis and form an ovum. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:ems, GOC:mtg_sensu, GOC:tb, ISBN:0198506732]
synonym: "oocyte arrangement" EXACT [GOC:dph, GOC:tb]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0048469 ! cell maturation
relationship: part_of GO:0048599 ! oocyte development

[Term]
id: GO:0007309
name: oocyte axis specification
namespace: biological_process
alt_id: GO:0048111
def: "The establishment, maintenance and elaboration of an axis in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
synonym: "oocyte axis determination" RELATED []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0009798 ! axis specification
is_a: GO:0044702 ! single organism reproductive process
relationship: part_of GO:0007308 ! oocyte construction

[Term]
id: GO:0007310
name: oocyte dorsal/ventral axis specification
namespace: biological_process
alt_id: GO:0008072
alt_id: GO:0048123
def: "The establishment, maintenance and elaboration of the dorsal/ventral axis of the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
synonym: "oocyte dorsal-ventral axis specification" EXACT [GOC:mah]
synonym: "oocyte dorsal/ventral axis determination" RELATED [GOC:dph, GOC:tb]
synonym: "oocyte dorsoventral axis specification" EXACT [GOC:mah]
is_a: GO:0007309 ! oocyte axis specification
is_a: GO:0009950 ! dorsal/ventral axis specification

[Term]
id: GO:0007311
name: maternal specification of dorsal/ventral axis, oocyte, germ-line encoded
namespace: biological_process
alt_id: GO:0048124
def: "Polarization of the oocyte along the dorsal-ventral axis, by a gene product encoded by cells of the germ line. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238]
synonym: "maternal determination of dorsal/ventral axis, oocyte, germ-line encoded" EXACT [GOC:dph, GOC:tb]
synonym: "maternal specification of dorsal-ventral axis, oocyte, germ-line encoded" EXACT [GOC:mah]
synonym: "maternal specification of dorsoventral axis, oocyte, germ-line encoded" EXACT [GOC:mah]
is_a: GO:0007310 ! oocyte dorsal/ventral axis specification

[Term]
id: GO:0007312
name: oocyte nucleus migration involved in oocyte dorsal/ventral axis specification
namespace: biological_process
alt_id: GO:0008102
alt_id: GO:0048128
def: "The directed movement of the oocyte nucleus within the cell as part of the establishment and maintenance of the dorsal/ventral axis of the oocyte. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mah, GOC:mtg_sensu, GOC:tb]
synonym: "oocyte axis determination, oocyte nuclear migration" EXACT []
synonym: "oocyte axis determination, oocyte nucleus migration" EXACT []
synonym: "oocyte nuclear migration during oocyte axis determination" EXACT []
synonym: "oocyte nucleus migration during oocyte axis determination" EXACT [GOC:dph, GOC:tb]
synonym: "oocyte nucleus migration during oocyte axis specification" RELATED [GOC:dph, GOC:tb]
is_a: GO:0007097 ! nuclear migration
is_a: GO:0030722 ! establishment of oocyte nucleus localization involved in oocyte dorsal/ventral axis specification

[Term]
id: GO:0007313
name: maternal specification of dorsal/ventral axis, oocyte, soma encoded
namespace: biological_process
alt_id: GO:0048125
def: "Polarization of the oocyte along the dorsal-ventral axis, by a gene product encoded by somatic cells. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238]
synonym: "maternal determination of dorsal/ventral axis, oocyte, soma encoded" EXACT [GOC:dph, GOC:tb]
synonym: "maternal specification of dorsal-ventral axis, oocyte, soma encoded" EXACT [GOC:mah]
synonym: "maternal specification of dorsoventral axis, oocyte, soma encoded" EXACT [GOC:mah]
is_a: GO:0007310 ! oocyte dorsal/ventral axis specification

[Term]
id: GO:0007314
name: oocyte anterior/posterior axis specification
namespace: biological_process
alt_id: GO:0048112
def: "Polarization of the oocyte along its anterior-posterior axis. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238]
synonym: "oocyte anterior/posterior axis determination" EXACT [GOC:dph, GOC:tb]
is_a: GO:0007309 ! oocyte axis specification
is_a: GO:0009948 ! anterior/posterior axis specification
relationship: part_of GO:0008358 ! maternal determination of anterior/posterior axis, embryo

[Term]
id: GO:0007315
name: pole plasm assembly
namespace: biological_process
alt_id: GO:0048113
def: "Establishment of the specialized cytoplasm found at the poles of the egg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu]
is_a: GO:0007028 ! cytoplasm organization
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0022607 ! cellular component assembly
relationship: part_of GO:0007314 ! oocyte anterior/posterior axis specification

[Term]
id: GO:0007316
name: pole plasm RNA localization
namespace: biological_process
alt_id: GO:0048116
def: "Any process in which RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [GOC:ai]
synonym: "establishment and maintenance of pole plasm RNA localization" EXACT []
synonym: "oocyte pole plasm RNA localization" EXACT []
synonym: "pole plasm RNA localisation" EXACT [GOC:mah]
is_a: GO:0006403 ! RNA localization
is_a: GO:0022414 ! reproductive process
relationship: part_of GO:0007315 ! pole plasm assembly

[Term]
id: GO:0007317
name: regulation of pole plasm oskar mRNA localization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:hb]
synonym: "regulation of oocyte pole plasm oskar mRNA localization" EXACT []
synonym: "regulation of pole plasm oskar mRNA localisation" EXACT [GOC:mah]
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0051128 ! regulation of cellular component organization
is_a: GO:0060281 ! regulation of oocyte development
is_a: GO:1902875 ! regulation of embryonic pattern specification
is_a: GO:1903429 ! regulation of cell maturation
is_a: GO:1904580 ! regulation of intracellular mRNA localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045451 ! pole plasm oskar mRNA localization
relationship: regulates GO:0045451 ! pole plasm oskar mRNA localization

[Term]
id: GO:0007318
name: pole plasm protein localization
namespace: biological_process
alt_id: GO:0048115
def: "Any process in which a protein is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [GOC:ai]
synonym: "establishment and maintenance of pole plasm protein localization" EXACT []
synonym: "oocyte pole plasm protein localization" EXACT []
synonym: "pole plasm protein localisation" EXACT [GOC:mah]
is_a: GO:0008105 ! asymmetric protein localization
is_a: GO:0022414 ! reproductive process
relationship: part_of GO:0007315 ! pole plasm assembly

[Term]
id: GO:0007319
name: negative regulation of oskar mRNA translation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate that oskar mRNAs are effectively translated into protein." [GOC:ems]
synonym: "down regulation of oskar mRNA translation" EXACT []
synonym: "down-regulation of oskar mRNA translation" EXACT []
synonym: "downregulation of oskar mRNA translation" EXACT []
synonym: "inhibition of oskar mRNA translation" NARROW []
is_a: GO:0017148 ! negative regulation of translation
is_a: GO:0046011 ! regulation of oskar mRNA translation

[Term]
id: GO:0007320
name: insemination
namespace: biological_process
def: "The introduction of semen or sperm into the genital tract of a female." [ISBN:0582227089]
xref: Wikipedia:Insemination
is_a: GO:0044703 ! multi-organism reproductive process
is_a: GO:0044706 ! multi-multicellular organism process
is_a: GO:0048609 ! multicellular organismal reproductive process
relationship: part_of GO:0007620 ! copulation

[Term]
id: GO:0007321
name: sperm displacement
namespace: biological_process
def: "The physical displacement of sperm stored from previous mating encounters." [PMID:10440373]
is_a: GO:0046692 ! sperm competition

[Term]
id: GO:0007323
name: peptide pheromone maturation
namespace: biological_process
alt_id: GO:0007324
alt_id: GO:0007326
alt_id: GO:0046613
def: "The generation of a mature, active peptide pheromone via processes unique to its processing and modification. An example of this process is found in Saccharomyces cerevisiae." [GOC:elh]
subset: gosubset_prok
synonym: "pheromone processing" EXACT []
is_a: GO:0051604 ! protein maturation

[Term]
id: GO:0007329
name: positive regulation of transcription from RNA polymerase II promoter by pheromones
namespace: biological_process
def: "Any process involving pheromones that activates or increases the rate of transcription from an RNA polymerase II promoter." [GOC:go_curators]
synonym: "activation of transcription from RNA polymerase II promoter by pheromones" NARROW []
synonym: "positive regulation of transcription from Pol II promoter by pheromones" EXACT []
synonym: "stimulation of transcription from RNA polymerase II promoter by pheromones" NARROW []
synonym: "up regulation of transcription from RNA polymerase II promoter by pheromones" EXACT []
synonym: "up-regulation of transcription from RNA polymerase II promoter by pheromones" EXACT []
synonym: "upregulation of transcription from RNA polymerase II promoter by pheromones" EXACT []
is_a: GO:0009371 ! positive regulation of transcription by pheromones
is_a: GO:0046019 ! regulation of transcription from RNA polymerase II promoter by pheromones
is_a: GO:1901522 ! positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus

[Term]
id: GO:0007336
name: obsolete bilateral process
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it gives no indication of what it refers to.
synonym: "bilateral process" EXACT []
is_obsolete: true

[Term]
id: GO:0007337
name: obsolete unilateral process
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it gives no indication of what it refers to.
synonym: "unilateral process" EXACT []
is_obsolete: true

[Term]
id: GO:0007338
name: single fertilization
namespace: biological_process
def: "The union of male and female gametes to form a zygote." [GOC:ems, GOC:mtg_sensu]
synonym: "zygote biosynthesis" RELATED []
synonym: "zygote formation" RELATED []
is_a: GO:0009566 ! fertilization

[Term]
id: GO:0007339
name: binding of sperm to zona pellucida
namespace: biological_process
def: "The process in which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place." [GOC:dph, ISBN:0878932437]
synonym: "ZPG binding" RELATED []
is_a: GO:0035036 ! sperm-egg recognition

[Term]
id: GO:0007340
name: acrosome reaction
namespace: biological_process
def: "The discharge, by sperm, of a single, anterior secretory granule following the sperm's attachment to the zona pellucida surrounding the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents into the egg." [GOC:dph, PMID:3886029]
xref: Wikipedia:Acrosome_reaction
is_a: GO:0022414 ! reproductive process
relationship: part_of GO:0007338 ! single fertilization

[Term]
id: GO:0007341
name: penetration of zona pellucida
namespace: biological_process
def: "The infiltration by sperm of the zona pellucida to reach the oocyte. The process involves digestive enzymes from a modified lysosome called the acrosome, situated at the head of the sperm." [GOC:jl, http://arbl.cvmbs.colostate.edu/hbooks/pathphys/reprod/fert/fert.html]
is_a: GO:0044703 ! multi-organism reproductive process
is_a: GO:0044706 ! multi-multicellular organism process
is_a: GO:0048609 ! multicellular organismal reproductive process
relationship: part_of GO:0007338 ! single fertilization

[Term]
id: GO:0007342
name: fusion of sperm to egg plasma membrane
namespace: biological_process
def: "The binding and fusion of a sperm, having penetrated the zona pellucida, with the plasma membrane of the oocyte. Binding occurs at the posterior (post-acrosomal) region of the sperm head." [GOC:jl, http://arbl.cvmbs.colostate.edu/hbooks/pathphys/reprod/fert/fert.html]
synonym: "sperm-oocyte fusion" NARROW []
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0045026 ! plasma membrane fusion
relationship: part_of GO:0007338 ! single fertilization

[Term]
id: GO:0007343
name: egg activation
namespace: biological_process
def: "The process in which the egg becomes metabolically active, initiates protein and DNA synthesis and undergoes structural changes to its cortex and/or cytoplasm." [GOC:bf, PMID:9630751]
xref: Wikipedia:Egg_activation
is_a: GO:0001775 ! cell activation
is_a: GO:0044702 ! single organism reproductive process
relationship: part_of GO:0007338 ! single fertilization

[Term]
id: GO:0007344
name: pronuclear fusion
namespace: biological_process
def: "The merging of two pronuclei in a fertilized egg to fuse and produce a single zygotic genome." [GOC:ems, ISBN:087969307X]
is_a: GO:0000741 ! karyogamy
is_a: GO:0022414 ! reproductive process
relationship: part_of GO:0007338 ! single fertilization

[Term]
id: GO:0007345
name: obsolete embryogenesis and morphogenesis
namespace: biological_process
def: "OBSOLETE. Formation and development of an embryo and its organized structures." [GOC:ems, ISBN:0070524300, ISBN:0140512888]
comment: This term was made obsolete because more appropriate terms were created. Morphogenesis in plants also occurs outside of embryogenesis.
synonym: "embryogenesis and morphogenesis" EXACT []
is_obsolete: true
consider: GO:0009653
consider: GO:0009790

[Term]
id: GO:0007346
name: regulation of mitotic cell cycle
namespace: biological_process
def: "Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
subset: goslim_pombe
synonym: "mitotic cell cycle modulation" EXACT []
synonym: "mitotic cell cycle regulation" EXACT []
synonym: "mitotic cell cycle regulator" RELATED []
synonym: "modulation of mitotic cell cycle progression" EXACT []
synonym: "regulation of mitotic cell cycle progression" EXACT []
synonym: "regulation of progression through mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051726 ! regulation of cell cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000278 ! mitotic cell cycle
relationship: regulates GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0007347
name: regulation of preblastoderm mitotic cell cycle
namespace: biological_process
def: "A cell cycle process that modulates the rate or extent of the progression through the preblastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "modulation of preblastoderm mitotic cell cycle progression" EXACT []
synonym: "preblastoderm mitotic cell cycle modulation" EXACT []
synonym: "preblastoderm mitotic cell cycle regulation" EXACT []
synonym: "preblastoderm mitotic cell cycle regulator" RELATED []
synonym: "regulation of preblastoderm mitotic cell cycle progression" EXACT []
synonym: "regulation of progression through preblastoderm mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
is_a: GO:0009794 ! regulation of mitotic cell cycle, embryonic
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035185 ! preblastoderm mitotic cell cycle
relationship: regulates GO:0035185 ! preblastoderm mitotic cell cycle

[Term]
id: GO:0007348
name: regulation of syncytial blastoderm mitotic cell cycle
namespace: biological_process
def: "A cell cycle process that modulates the rate or extent of the progression through the syncytial blastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "modulation of syncytial blastoderm cell cycle progression" EXACT []
synonym: "regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of syncytial blastoderm cell cycle" EXACT []
synonym: "regulation of syncytial blastoderm cell cycle progression" EXACT []
synonym: "syncytial blastoderm cell cycle modulation" EXACT []
synonym: "syncytial blastoderm cell cycle regulation" EXACT []
synonym: "syncytial blastoderm cell cycle regulator" RELATED []
is_a: GO:0009794 ! regulation of mitotic cell cycle, embryonic
is_a: GO:0022402 ! cell cycle process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035186 ! syncytial blastoderm mitotic cell cycle
relationship: regulates GO:0035186 ! syncytial blastoderm mitotic cell cycle

[Term]
id: GO:0007349
name: cellularization
namespace: biological_process
alt_id: GO:0009796
def: "The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development." [GOC:go_curators, GOC:mtg_sensu, ISBN:0716731363]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0007275 ! multicellular organism development

[Term]
id: GO:0007350
name: blastoderm segmentation
namespace: biological_process
def: "The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
is_a: GO:0009880 ! embryonic pattern specification
is_a: GO:0035282 ! segmentation

[Term]
id: GO:0007351
name: tripartite regional subdivision
namespace: biological_process
def: "Subdivision of the embryo along the anterior/posterior axis into anterior, posterior and terminal regions." [GOC:dph, GOC:isa_complete, http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0007350 ! blastoderm segmentation

[Term]
id: GO:0007352
name: zygotic specification of dorsal/ventral axis
namespace: biological_process
def: "The specification of the dorsal/ventral axis of the embryo, through the products of genes expressed in the zygote." [GOC:bf]
synonym: "zygotic determination of dorsal-ventral axis" RELATED [GOC:mah]
synonym: "zygotic determination of dorsal/ventral axis" RELATED [GOC:dph]
synonym: "zygotic determination of dorsoventral axis" RELATED [GOC:mah]
is_a: GO:0000578 ! embryonic axis specification
is_a: GO:0009950 ! dorsal/ventral axis specification

[Term]
id: GO:0007353
name: obsolete ventral/lateral system
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it does not describe a biological process.
synonym: "ventral/lateral system" EXACT []
is_obsolete: true
consider: GO:0009880

[Term]
id: GO:0007354
name: zygotic determination of anterior/posterior axis, embryo
namespace: biological_process
def: "The specification of the anterior/posterior axis of the embryo by products of genes expressed in the zygote; exemplified in insects by the gap genes, pair rule genes and segment polarity gene cascade." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
is_a: GO:0008595 ! anterior/posterior axis specification, embryo

[Term]
id: GO:0007355
name: anterior region determination
namespace: biological_process
def: "Specification of the anterior (head and thoracic segments) of the embryo by the gap genes; exemplified in insects by the actions of hunchback gene product." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
is_a: GO:0009952 ! anterior/posterior pattern specification
relationship: part_of GO:0007354 ! zygotic determination of anterior/posterior axis, embryo

[Term]
id: GO:0007356
name: thorax and anterior abdomen determination
namespace: biological_process
def: "Specification of the central (trunk) regions of the embryo by the gap genes; exemplified in insects by the actions of the Kruppel gene product." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
is_a: GO:0009952 ! anterior/posterior pattern specification
relationship: part_of GO:0007354 ! zygotic determination of anterior/posterior axis, embryo

[Term]
id: GO:0007357
name: positive regulation of central gap gene transcription
namespace: biological_process
def: "The activation of genes encoding transcription factors in the central region of an insect embryo by a combination of maternal regulatory signals and interactions among themselves; exemplified by the activation of expression of the Drosophila Kruppel gene by the hunchback and bicoid gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
synonym: "activation of central gap gene" BROAD []
synonym: "activation of central gap gene transcription" NARROW []
synonym: "stimulation of central gap gene transcription" NARROW []
synonym: "up regulation of central gap gene transcription" EXACT []
synonym: "up-regulation of central gap gene transcription" EXACT []
synonym: "upregulation of central gap gene transcription" EXACT []
is_a: GO:0044324 ! regulation of transcription involved in anterior/posterior axis specification
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
relationship: part_of GO:0007356 ! thorax and anterior abdomen determination

[Term]
id: GO:0007358
name: establishment of central gap gene boundaries
namespace: biological_process
def: "Specification of the borders of central gap gene expression mediated largely by the effects of other gap genes; in insects this is exemplified by knirps repression of Kruppel." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
is_a: GO:0048859 ! formation of anatomical boundary
relationship: part_of GO:0007356 ! thorax and anterior abdomen determination

[Term]
id: GO:0007359
name: posterior abdomen determination
namespace: biological_process
def: "The regionalization process in which the posterior (abdominal) regions of the embryo are specified by the gap genes." [GOC:dph, GOC:isa_complete, http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
comment: Note that this process is exemplified in insects by the actions of the knirps gene product.
is_a: GO:0009952 ! anterior/posterior pattern specification
relationship: part_of GO:0007354 ! zygotic determination of anterior/posterior axis, embryo

[Term]
id: GO:0007360
name: positive regulation of posterior gap gene transcription
namespace: biological_process
def: "The activation of genes encoding transcription factors in the posterior region of an insect embryo by a combination of maternal regulatory signals and interactions among themselves; exemplified by the activation of expression of the Drosophila knirps gene." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
synonym: "activation of posterior gap gene" BROAD []
synonym: "activation of posterior gap gene transcription" NARROW []
synonym: "knirps activation" NARROW []
synonym: "stimulation of posterior gap gene transcription" NARROW []
synonym: "up regulation of posterior gap gene transcription" EXACT []
synonym: "up-regulation of posterior gap gene transcription" EXACT []
synonym: "upregulation of posterior gap gene transcription" EXACT []
is_a: GO:0044324 ! regulation of transcription involved in anterior/posterior axis specification
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
relationship: part_of GO:0007359 ! posterior abdomen determination

[Term]
id: GO:0007361
name: establishment of posterior gap gene boundaries
namespace: biological_process
def: "Specification of the borders of posterior gap gene expression mediated largely by the effects of other gap genes; in insects this is exemplified by hunchback and tailless repression of knirps." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
is_a: GO:0048859 ! formation of anatomical boundary
relationship: part_of GO:0007359 ! posterior abdomen determination

[Term]
id: GO:0007362
name: terminal region determination
namespace: biological_process
def: "Specification of the terminal regions (the two non-segmented ends) of the embryo by the gap genes; exemplified in insects by the actions of huckebein and tailless gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
is_a: GO:0009880 ! embryonic pattern specification
relationship: part_of GO:0007354 ! zygotic determination of anterior/posterior axis, embryo

[Term]
id: GO:0007363
name: positive regulation of terminal gap gene transcription
namespace: biological_process
def: "The activation of genes encoding transcription factors at the anterior and posterior ends of an insect embryo by a combination of maternal regulatory signals and interactions among themselves; exemplified by the activation of expression of the Drosophila tailless and huckebein genes." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
synonym: "activation of terminal gap gene" BROAD []
synonym: "activation of terminal gap gene transcription" NARROW []
synonym: "stimulation of terminal gap gene transcription" NARROW []
synonym: "up regulation of terminal gap gene transcription" EXACT []
synonym: "up-regulation of terminal gap gene transcription" EXACT []
synonym: "upregulation of terminal gap gene transcription" EXACT []
is_a: GO:0044324 ! regulation of transcription involved in anterior/posterior axis specification
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
relationship: part_of GO:0007362 ! terminal region determination

[Term]
id: GO:0007364
name: establishment of terminal gap gene boundary
namespace: biological_process
def: "Specification of the borders of terminal gap gene expression mediated largely by the effects of other gap genes." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
is_a: GO:0048859 ! formation of anatomical boundary
relationship: part_of GO:0007362 ! terminal region determination

[Term]
id: GO:0007365
name: periodic partitioning
namespace: biological_process
def: "The regionalization process that divides the spatial regions of an embryo into serially repeated regions." [GOC:dph, GOC:isa_complete, GOC:ma]
comment: Note that examples of periodic partitions are tagmata, segments or parasegments.
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0007350 ! blastoderm segmentation

[Term]
id: GO:0007366
name: periodic partitioning by pair rule gene
namespace: biological_process
def: "Allocation of cells to parasegments in the embryo, through the action of overlapping series of pair rule gene activities." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238]
is_a: GO:0007365 ! periodic partitioning
is_a: GO:0009952 ! anterior/posterior pattern specification

[Term]
id: GO:0007367
name: segment polarity determination
namespace: biological_process
def: "Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238]
is_a: GO:0007365 ! periodic partitioning

[Term]
id: GO:0007368
name: determination of left/right symmetry
namespace: biological_process
def: "The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry." [GOC:dph, GOC:jid]
synonym: "determination of left/right asymmetry" EXACT [GOC:dph]
is_a: GO:0009855 ! determination of bilateral symmetry

[Term]
id: GO:0007369
name: gastrulation
namespace: biological_process
def: "A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [GOC:curators, ISBN:9780878933846]
xref: Wikipedia:Gastrulation
is_a: GO:0048598 ! embryonic morphogenesis
relationship: has_part GO:0001705 ! ectoderm formation
relationship: has_part GO:0001706 ! endoderm formation
relationship: has_part GO:0001707 ! mesoderm formation

[Term]
id: GO:0007370
name: ventral furrow formation
namespace: biological_process
def: "Formation of a ventral indentation (furrow) from the blastoderm epithelium, which is internalized to form a tube in the interior of the embryo, marking the start of gastrulation." [ISBN:08795694238]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0010004 ! gastrulation involving germ band extension

[Term]
id: GO:0007371
name: ventral midline determination
namespace: biological_process
alt_id: GO:0007372
alt_id: GO:0007373
def: "The regionalization process in which the area where the ventral midline will form is specified." [GOC:bf, GOC:isa_complete, GOC:vk]
synonym: "determination of anterior border of ventral midline" NARROW []
synonym: "determination of posterior border of ventral midline" NARROW []
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0007418 ! ventral midline development

[Term]
id: GO:0007374
name: posterior midgut invagination
namespace: biological_process
def: "Formation of a cup-shaped invagination at the posterior end of the embryo, bringing the posterior midgut and hindgut primordia into the interior." [ISBN:08795694238]
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0060571 ! morphogenesis of an epithelial fold
relationship: part_of GO:0010004 ! gastrulation involving germ band extension

[Term]
id: GO:0007375
name: anterior midgut invagination
namespace: biological_process
def: "Internalization of the anterior midgut into the interior of the embryo." [ISBN:08795694238]
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
relationship: part_of GO:0010004 ! gastrulation involving germ band extension

[Term]
id: GO:0007376
name: cephalic furrow formation
namespace: biological_process
def: "Formation of a partial necklace of inturning tissue on the lateral sides of the embryo, along the dorsal-ventral axis. This furrow demarcates head from thorax in the developing protostome." [ISBN:08795694238]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0010004 ! gastrulation involving germ band extension

[Term]
id: GO:0007377
name: germ-band extension
namespace: biological_process
def: "Elongation of the germ band on the ventral side of the embryo, accompanied by a halving in width. The elongation process pushes the posterior midgut invagination closed and compresses the amnioserosa further." [ISBN:08795694238]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0010004 ! gastrulation involving germ band extension

[Term]
id: GO:0007378
name: amnioserosa formation
namespace: biological_process
def: "Formation of the amnioserosa, an epithelium that occupies a hole in the embryonic dorsal epidermis. This occurs by the transformation of a narrow strip of cells at the dorsal midline of the blastoderm from columnar to squamous cells, accompanied by a lateral shift." [ISBN:08795694238]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0010004 ! gastrulation involving germ band extension

[Term]
id: GO:0007379
name: segment specification
namespace: biological_process
def: "The process in which segments assume individual identities; exemplified in insects by the actions of the products of the homeotic genes." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
is_a: GO:0007389 ! pattern specification process
relationship: part_of GO:0035282 ! segmentation

[Term]
id: GO:0007380
name: specification of segmental identity, head
namespace: biological_process
def: "The specification of the characteristic structures of the head segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437]
is_a: GO:0007379 ! segment specification
relationship: part_of GO:0035287 ! head segmentation

[Term]
id: GO:0007381
name: specification of segmental identity, labial segment
namespace: biological_process
def: "The specification of the characteristic structures of the labial segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437]
comment: See also the fly_anatomy.ontology term 'labial segment ; FBbt:00000014'.
is_a: GO:0007380 ! specification of segmental identity, head
relationship: part_of GO:0035289 ! posterior head segmentation

[Term]
id: GO:0007382
name: specification of segmental identity, maxillary segment
namespace: biological_process
def: "The specification of the characteristic structures of the maxillary segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437]
comment: See also the fly_anatomy.ontology term 'maxillary segment ; FBbt:00000013'.
is_a: GO:0007380 ! specification of segmental identity, head
relationship: part_of GO:0035289 ! posterior head segmentation

[Term]
id: GO:0007383
name: specification of segmental identity, antennal segment
namespace: biological_process
def: "The specification of the characteristic structures of the antennal segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437]
comment: See also the fly_anatomy.ontology term 'antennal segment ; FBbt:00000009'.
is_a: GO:0007380 ! specification of segmental identity, head
relationship: part_of GO:0035288 ! anterior head segmentation

[Term]
id: GO:0007384
name: specification of segmental identity, thorax
namespace: biological_process
def: "The specification of the characteristic structures of the thoracic segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437]
is_a: GO:0035292 ! specification of segmental identity, trunk

[Term]
id: GO:0007385
name: specification of segmental identity, abdomen
namespace: biological_process
def: "The specification of the characteristic structures of the abdominal segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437]
is_a: GO:0035292 ! specification of segmental identity, trunk

[Term]
id: GO:0007386
name: compartment pattern specification
namespace: biological_process
def: "The regionalization process in which embryonic segments are divided into compartments that will result in differences in cell differentiation." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
synonym: "compartment specification" RELATED [GOC:dph]
is_a: GO:0009952 ! anterior/posterior pattern specification

[Term]
id: GO:0007387
name: anterior compartment pattern formation
namespace: biological_process
def: "The process giving rise to specification of cell identity in the anterior compartments of the segmented embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
synonym: "anterior compartment pattern specification" RELATED [GOC:dph]
is_a: GO:0007386 ! compartment pattern specification

[Term]
id: GO:0007388
name: posterior compartment specification
namespace: biological_process
def: "The process involved in the specification of cell identity in the posterior compartments of the segmented embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
is_a: GO:0007386 ! compartment pattern specification

[Term]
id: GO:0007389
name: pattern specification process
namespace: biological_process
def: "Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate." [GOC:go_curators, GOC:isa_complete, ISBN:0521436125]
synonym: "pattern biosynthesis" RELATED []
synonym: "pattern formation" RELATED []
is_a: GO:0044707 ! single-multicellular organism process
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0007275 ! multicellular organism development

[Term]
id: GO:0007390
name: germ-band shortening
namespace: biological_process
def: "The spreading of the amnioserosa from its compressed state to cover the whole of the dorsal surface. Initiating in the thorax and spreading posteriorly, it is accompanied by the transition from a parasegmental to segmental division of the embryo." [GOC:bf, PMID:12147138]
synonym: "germ-band retraction" EXACT []
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm

[Term]
id: GO:0007391
name: dorsal closure
namespace: biological_process
def: "The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720]
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm

[Term]
id: GO:0007392
name: initiation of dorsal closure
namespace: biological_process
def: "Events that occur at the start of dorsal closure." [GOC:bf]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0007391 ! dorsal closure

[Term]
id: GO:0007393
name: dorsal closure, leading edge cell fate determination
namespace: biological_process
def: "The cell fate determination process in which a cell within the dorsal ectoderm becomes capable of differentiating autonomously into a leading edge cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:bf, GOC:go_curators, PMID:12147138]
is_a: GO:0035028 ! leading edge cell fate determination
intersection_of: GO:0035028 ! leading edge cell fate determination
intersection_of: part_of GO:0007391 ! dorsal closure
relationship: part_of GO:0007391 ! dorsal closure
relationship: part_of GO:0035029 ! dorsal closure, leading edge cell fate commitment

[Term]
id: GO:0007394
name: dorsal closure, elongation of leading edge cells
namespace: biological_process
def: "The change in shape of cells at the dorsal-most (leading) edge of the epidermis from being polygonal to being elongated in the dorsal/ventral axis." [PMID:12147138]
is_a: GO:0009826 ! unidimensional cell growth
is_a: GO:0016476 ! regulation of embryonic cell shape
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0007392 ! initiation of dorsal closure

[Term]
id: GO:0007395
name: dorsal closure, spreading of leading edge cells
namespace: biological_process
def: "Dorsally-directed movement of a cell at the leading edge of the epithelium over the amnioserosa." [GOC:bf, PMID:12147138]
is_a: GO:0016477 ! cell migration
relationship: part_of GO:0007391 ! dorsal closure

[Term]
id: GO:0007396
name: suture of dorsal opening
namespace: biological_process
def: "Closure of the dorsal hole. Filopodia extending from each leading edge interdigitate at the dorsal midline and appear to prime the formation of adherens junctions between the two rows of leading edge cells. Newly formed septate junctions are also used to seal the dorsal hole." [GOC:bf, PMID:12147138]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0007391 ! dorsal closure

[Term]
id: GO:0007397
name: obsolete histogenesis and organogenesis
namespace: biological_process
def: "OBSOLETE. The generation of organized tissues or of whole organs." [GOC:ems]
comment: This term was made obsolete because more appropriate terms were created.
synonym: "histogenesis and organogenesis" EXACT []
is_obsolete: true
consider: GO:0009887
consider: GO:0009888

[Term]
id: GO:0007398
name: ectoderm development
namespace: biological_process
def: "The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation." [GOC:dph, GOC:tb]
is_a: GO:0009888 ! tissue development

[Term]
id: GO:0007399
name: nervous system development
namespace: biological_process
def: "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
synonym: "pan-neural process" RELATED []
is_a: GO:0048731 ! system development

[Term]
id: GO:0007400
name: neuroblast fate determination
namespace: biological_process
alt_id: GO:0007408
alt_id: GO:0043347
alt_id: GO:0043348
def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this process is found in Mus musculus." [GOC:go_curators]
synonym: "neuroblast cell fate determination" EXACT []
synonym: "neuroblast identity determination" EXACT []
is_a: GO:0048867 ! stem cell fate determination
relationship: part_of GO:0014017 ! neuroblast fate commitment

[Term]
id: GO:0007401
name: obsolete pan-neural process
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because its meaning is ambiguous.
synonym: "pan-neural process" EXACT []
is_obsolete: true
consider: GO:0007399
consider: GO:0050877

[Term]
id: GO:0007402
name: ganglion mother cell fate determination
namespace: biological_process
def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a ganglion mother cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators]
is_a: GO:0048867 ! stem cell fate determination

[Term]
id: GO:0007403
name: glial cell fate determination
namespace: biological_process
alt_id: GO:0043361
def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a glial cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators, GOC:mtg_sensu]
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0021781 ! glial cell fate commitment

[Term]
id: GO:0007405
name: neuroblast proliferation
namespace: biological_process
alt_id: GO:0043349
alt_id: GO:0043350
def: "The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron." [GOC:ai, GOC:mtg_sensu, GOC:sart]
is_a: GO:0061351 ! neural precursor cell proliferation
is_a: GO:0072089 ! stem cell proliferation
relationship: part_of GO:0048699 ! generation of neurons

[Term]
id: GO:0007406
name: negative regulation of neuroblast proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the proliferation of neuroblasts." [GOC:ai]
synonym: "down regulation of neuroblast proliferation" EXACT []
synonym: "down-regulation of neuroblast proliferation" EXACT []
synonym: "downregulation of neuroblast proliferation" EXACT []
synonym: "inhibition of neuroblast proliferation" NARROW []
synonym: "suppression of neuroblast proliferation" EXACT []
is_a: GO:0050768 ! negative regulation of neurogenesis
is_a: GO:1902692 ! regulation of neuroblast proliferation
is_a: GO:2000178 ! negative regulation of neural precursor cell proliferation
is_a: GO:2000647 ! negative regulation of stem cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007405 ! neuroblast proliferation
relationship: negatively_regulates GO:0007405 ! neuroblast proliferation

[Term]
id: GO:0007407
name: neuroblast activation
namespace: biological_process
alt_id: GO:0043351
alt_id: GO:0043352
def: "A change in the morphology or behavior of a neuroblast resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:go_curators, GOC:mtg_sensu]
is_a: GO:0001775 ! cell activation
relationship: part_of GO:0048699 ! generation of neurons

[Term]
id: GO:0007409
name: axonogenesis
namespace: biological_process
alt_id: GO:0007410
def: "De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732]
comment: Note that 'axonogenesis' differs from 'axon development' in that the latter also covers other processes, such as axon regeneration (regrowth after loss or damage, not necessarily of the whole axon).
synonym: "axon growth" NARROW []
synonym: "axon morphogenesis" EXACT [GOC:bf, PMID:23517308]
synonym: "neuron long process generation" EXACT systematic_synonym []
is_a: GO:0048812 ! neuron projection morphogenesis
relationship: part_of GO:0048667 ! cell morphogenesis involved in neuron differentiation
relationship: part_of GO:0061564 ! axon development

[Term]
id: GO:0007411
name: axon guidance
namespace: biological_process
alt_id: GO:0008040
def: "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
synonym: "axon chemotaxis" RELATED [GOC:curators]
synonym: "axon growth cone guidance" NARROW []
synonym: "axon pathfinding" EXACT [GOC:mah]
xref: Reactome:REACT_104226 "Axon guidance, Xenopus tropicalis"
xref: Reactome:REACT_108197 "Axon guidance, Schizosaccharomyces pombe"
xref: Reactome:REACT_110262 "Axon guidance, Drosophila melanogaster"
xref: Reactome:REACT_112315 "Axon guidance, Plasmodium falciparum"
xref: Reactome:REACT_114665 "Axon guidance, Arabidopsis thaliana"
xref: Reactome:REACT_115127 "Axon guidance, Oryza sativa"
xref: Reactome:REACT_18266 "Axon guidance, Homo sapiens"
xref: Reactome:REACT_29678 "Axon guidance, Taeniopygia guttata"
xref: Reactome:REACT_29862 "Axon guidance, Caenorhabditis elegans"
xref: Reactome:REACT_34580 "Axon guidance, Dictyostelium discoideum"
xref: Reactome:REACT_77452 "Axon guidance, Sus scrofa"
xref: Reactome:REACT_77923 "Axon guidance, Danio rerio"
xref: Reactome:REACT_83818 "Axon guidance, Saccharomyces cerevisiae"
xref: Reactome:REACT_86479 "Axon guidance, Gallus gallus"
xref: Reactome:REACT_88453 "Axon guidance, Bos taurus"
xref: Reactome:REACT_92778 "Axon guidance, Mus musculus"
xref: Reactome:REACT_94408 "Axon guidance, Rattus norvegicus"
xref: Reactome:REACT_95076 "Axon guidance, Canis familiaris"
xref: Wikipedia:Axon_guidance
is_a: GO:0097485 ! neuron projection guidance
relationship: part_of GO:0007409 ! axonogenesis

[Term]
id: GO:0007412
name: axon target recognition
namespace: biological_process
def: "The process in which an axon recognizes and binds to a set of cells with which it may form stable connections." [ISBN:0878932437]
is_a: GO:0007154 ! cell communication
relationship: part_of GO:0007409 ! axonogenesis

[Term]
id: GO:0007413
name: axonal fasciculation
namespace: biological_process
def: "The collection of axons into a bundle of rods, known as a fascicle." [GOC:dgh]
synonym: "fasciculation of neuron" RELATED []
is_a: GO:0008038 ! neuron recognition
relationship: part_of GO:0061564 ! axon development

[Term]
id: GO:0007414
name: axonal defasciculation
namespace: biological_process
def: "Separation of axons away from a bundle of axons known as a fascicle." [GOC:dgh, ISBN:039751820X]
synonym: "defasciculation of neuron" RELATED []
is_a: GO:0008038 ! neuron recognition
relationship: part_of GO:0061564 ! axon development

[Term]
id: GO:0007415
name: defasciculation of motor neuron axon
namespace: biological_process
def: "Separation of a motor axon away from a bundle of axons known as a fascicle." [GOC:dgh]
is_a: GO:0007414 ! axonal defasciculation

[Term]
id: GO:0007416
name: synapse assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:mah]
subset: goslim_synapse
synonym: "synapse biogenesis" EXACT [GOC:mah]
synonym: "synaptogenesis" EXACT [GOC:mah]
xref: Wikipedia:Synaptogenesis
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0050808 ! synapse organization
relationship: part_of GO:0007399 ! nervous system development

[Term]
id: GO:0007417
name: central nervous system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089]
synonym: "CNS development" EXACT []
xref: Wikipedia:Neural_development
is_a: GO:0048731 ! system development
relationship: part_of GO:0007399 ! nervous system development

[Term]
id: GO:0007418
name: ventral midline development
namespace: biological_process
def: "The process whose specific outcome is the progression of the ventral midline over time, from its formation to the mature structure. In protostomes (such as insects, snails and worms) as well as deuterostomes (vertebrates), the midline is an embryonic region that functions in patterning of the adjacent nervous tissue. The ventral midline in insects is a cell population extending along the ventral surface of the embryo and is the region from which cells detach to form the ventrally located nerve cords. In vertebrates, the midline is originally located dorsally. During development, it folds inwards and becomes the ventral part of the dorsally located neural tube and is then called the ventral midline, or floor plate." [GOC:bf, GOC:go_curators, PMID:12075342]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007417 ! central nervous system development

[Term]
id: GO:0007419
name: ventral cord development
namespace: biological_process
def: "The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html]
is_a: GO:0009888 ! tissue development
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048513 ! animal organ development
relationship: part_of GO:0007417 ! central nervous system development

[Term]
id: GO:0007420
name: brain development
namespace: biological_process
def: "The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048513 ! animal organ development
relationship: part_of GO:0007417 ! central nervous system development
relationship: part_of GO:0060322 ! head development

[Term]
id: GO:0007421
name: stomatogastric nervous system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the stomatogastric nervous system over time, from its formation to the mature structure." [GOC:jid]
is_a: GO:0048731 ! system development
relationship: part_of GO:0007399 ! nervous system development

[Term]
id: GO:0007422
name: peripheral nervous system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010]
is_a: GO:0048731 ! system development
relationship: part_of GO:0007399 ! nervous system development

[Term]
id: GO:0007423
name: sensory organ development
namespace: biological_process
def: "The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators]
synonym: "sense organ development" EXACT [GOC:dph]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048513 ! animal organ development

[Term]
id: GO:0007424
name: open tracheal system development
namespace: biological_process
def: "The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828]
comment: See also the fly_anatomy.ontology term 'tracheal system ; FBbt:00005024'.
is_a: GO:0060541 ! respiratory system development

[Term]
id: GO:0007425
name: epithelial cell fate determination, open tracheal system
namespace: biological_process
alt_id: GO:0046846
def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into an epithelial cell within an open tracheal system regardless of its environment; upon determination, the cell fate cannot be reversed. Tracheal cells are set aside as 10 clusters of approximately 80 cells on each side of the embryo (termed tracheal placodes). An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11063940]
synonym: "tracheal cell fate determination" BROAD []
synonym: "tracheal epithelial cell fate determination" EXACT []
synonym: "tracheal placode cell fate determination" RELATED []
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0007424 ! open tracheal system development

[Term]
id: GO:0007426
name: tracheal outgrowth, open tracheal system
namespace: biological_process
def: "The projection of branches of an open tracheal system towards their target tissues. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
is_a: GO:0035239 ! tube morphogenesis
relationship: part_of GO:0007424 ! open tracheal system development

[Term]
id: GO:0007427
name: epithelial cell migration, open tracheal system
namespace: biological_process
def: "The orderly movement of epithelial cells during development of an open tracheal system. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
synonym: "tracheal cell migration" BROAD []
synonym: "tracheal epithelial cell migration" RELATED []
is_a: GO:0010631 ! epithelial cell migration
relationship: part_of GO:0007424 ! open tracheal system development

[Term]
id: GO:0007428
name: primary branching, open tracheal system
namespace: biological_process
def: "Formation of primary branches in the open tracheal system. These form from small groups of cells that migrate out at specific positions, organizing into tubes as they migrate. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html]
synonym: "primary tracheal branching" EXACT []
is_a: GO:0060446 ! branching involved in open tracheal system development

[Term]
id: GO:0007429
name: secondary branching, open tracheal system
namespace: biological_process
def: "Sprouting of secondary branches in an open tracheal system. These form from the tips of primary branches and are formed by individual cells that roll up into unicellular tubes. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html]
synonym: "secondary tracheal branching" EXACT []
is_a: GO:0060446 ! branching involved in open tracheal system development

[Term]
id: GO:0007430
name: terminal branching, open tracheal system
namespace: biological_process
def: "Formation of terminal branches in the open tracheal system. These are long cytoplasmic extensions that form fine tubules that transport oxygen directly to the tissues. An example of the process is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html]
synonym: "terminal branching of trachea, cytoplasmic projection extension" EXACT []
is_a: GO:0060446 ! branching involved in open tracheal system development

[Term]
id: GO:0007431
name: salivary gland development
namespace: biological_process
def: "The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity." [GOC:jid, UBERON:0001044]
is_a: GO:0048732 ! gland development
relationship: part_of GO:0035272 ! exocrine system development

[Term]
id: GO:0007432
name: salivary gland boundary specification
namespace: biological_process
def: "Determination of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland." [PMID:11598957]
synonym: "salivary gland determination" EXACT []
is_a: GO:0010160 ! formation of organ boundary
relationship: part_of GO:0007431 ! salivary gland development

[Term]
id: GO:0007433
name: larval salivary gland boundary specification
namespace: biological_process
def: "Determination in a larval organism of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland." [GOC:tb, PMID:11598957]
synonym: "larval salivary gland determination" BROAD [GOC:tb]
is_a: GO:0007432 ! salivary gland boundary specification
relationship: part_of GO:0002168 ! instar larval development

[Term]
id: GO:0007434
name: adult salivary gland boundary specification
namespace: biological_process
def: "Determination in an adult organism of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland." [GOC:tb, PMID:11598957]
synonym: "larval salivary gland determination" BROAD [GOC:tb]
is_a: GO:0007432 ! salivary gland boundary specification

[Term]
id: GO:0007435
name: salivary gland morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid]
is_a: GO:0022612 ! gland morphogenesis
relationship: part_of GO:0007431 ! salivary gland development

[Term]
id: GO:0007436
name: larval salivary gland morphogenesis
namespace: biological_process
def: "The process, occurring in the larva, by which the anatomical structures of the salivary gland are generated and organized." [GOC:jid]
is_a: GO:0007435 ! salivary gland morphogenesis
is_a: GO:0009886 ! post-embryonic morphogenesis
relationship: part_of GO:0002168 ! instar larval development

[Term]
id: GO:0007437
name: adult salivary gland morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the adult salivary gland are generated and organized." [GOC:go_curators]
is_a: GO:0007435 ! salivary gland morphogenesis

[Term]
id: GO:0007438
name: oenocyte development
namespace: biological_process
def: "The process whose specific outcome is the progression of the oenocyte over time, from its formation to the mature structure. The oenocytes are large secretory cells found in clusters underlying the epidermis of larval abdominal segments." [GOC:bf, PMID:11171397]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0001742 ! oenocyte differentiation

[Term]
id: GO:0007439
name: ectodermal digestive tract development
namespace: biological_process
def: "The process whose specific outcome is the progression of the ectodermal digestive tract over time, from its formation to the mature structure. The ectodermal digestive tract includes those portions that are derived from ectoderm." [GOC:curators]
synonym: "ectodermal gut development" RELATED [GOC:dph]
is_a: GO:0048729 ! tissue morphogenesis
relationship: part_of GO:0048565 ! digestive tract development

[Term]
id: GO:0007440
name: foregut morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the foregut are generated and organized." [GOC:jid]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0048546 ! digestive tract morphogenesis

[Term]
id: GO:0007441
name: anterior midgut (ectodermal) morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the anterior midgut (ectodermal) are generated and organized." [GOC:go_curators]
is_a: GO:0002009 ! morphogenesis of an epithelium
relationship: part_of GO:0048567 ! ectodermal digestive tract morphogenesis

[Term]
id: GO:0007442
name: hindgut morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the hindgut are generated and organized." [GOC:jid]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0048546 ! digestive tract morphogenesis
relationship: part_of GO:0061525 ! hindgut development

[Term]
id: GO:0007443
name: Malpighian tubule morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut." [GOC:bf, ISBN:0582227089]
comment: See also the fly_anatomy.ontology term 'Malpighian tubule ; FBbt:00005786'.
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0061333 ! renal tubule morphogenesis
relationship: part_of GO:0048619 ! embryonic hindgut morphogenesis
relationship: part_of GO:0072002 ! Malpighian tubule development

[Term]
id: GO:0007444
name: imaginal disc development
namespace: biological_process
def: "The process whose specific outcome is the progression of the imaginal disc over time, from its formation to the metamorphosis to form adult structures. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.)." [GOC:bf, ISBN:0879694238]
is_a: GO:0035295 ! tube development
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048513 ! animal organ development
is_a: GO:0060429 ! epithelium development

[Term]
id: GO:0007445
name: determination of imaginal disc primordium
namespace: biological_process
def: "Allocation of embryonic cells to the imaginal disc founder populations, groups of cells that are committed to contribute to the formation of an imaginal disc compartment." [ISBN:0879694238]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0007444 ! imaginal disc development

[Term]
id: GO:0007446
name: imaginal disc growth
namespace: biological_process
def: "The increase in mass of imaginal discs by cell proliferation prior to metamorphosis. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:bf, GOC:jid, PMID:10679387]
is_a: GO:0035265 ! organ growth
relationship: part_of GO:0007444 ! imaginal disc development

[Term]
id: GO:0007447
name: imaginal disc pattern formation
namespace: biological_process
def: "The regionalization process that results in defined areas of the imaginal disc that will undergo specific cell differentaiton. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult appendages (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:dph, GOC:isa_complete, GOC:jid]
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0007444 ! imaginal disc development

[Term]
id: GO:0007448
name: anterior/posterior pattern specification, imaginal disc
namespace: biological_process
def: "The establishment, maintenance and elaboration of the anterior/posterior axis of the imaginal disc. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that rapidly develop into adult appendages during metamorphosis from larval to adult form." [GOC:bf, ISBN:0879694238]
is_a: GO:0007447 ! imaginal disc pattern formation
is_a: GO:0009952 ! anterior/posterior pattern specification

[Term]
id: GO:0007449
name: proximal/distal pattern formation, imaginal disc
namespace: biological_process
def: "The establishment, maintenance and elaboration of the proximal/distal axis of the imaginal disc. Imaginal disks are masses of hypodermic cells, carried by the larvae of some insects after leaving the egg, from which masses the wings and legs of the adult are subsequently formed." [GOC:jid, ISBN:0879694238]
is_a: GO:0007447 ! imaginal disc pattern formation
is_a: GO:0009954 ! proximal/distal pattern formation

[Term]
id: GO:0007450
name: dorsal/ventral pattern formation, imaginal disc
namespace: biological_process
def: "The establishment, maintenance and elaboration of the dorsal/ventral axis of the imaginal disc. Imaginal disks are masses of hypodermic cells, carried by the larvae of some insects after leaving the egg, from which masses the wings and legs of the adult are subsequently formed." [GOC:jid, ISBN:0879694238]
synonym: "dorsal-ventral pattern formation, imaginal disc" EXACT [GOC:mah]
synonym: "dorsoventral pattern formation, imaginal disc" EXACT [GOC:mah]
is_a: GO:0007447 ! imaginal disc pattern formation
is_a: GO:0009953 ! dorsal/ventral pattern formation

[Term]
id: GO:0007451
name: dorsal/ventral lineage restriction, imaginal disc
namespace: biological_process
def: "Formation and/or maintenance of a lineage boundary between dorsal and ventral compartments that cells cannot cross, thus separating the populations of cells in each compartment." [GOC:bf, PMID:10625531, PMID:9374402]
synonym: "dorsal-ventral lineage restriction, imaginal disc" EXACT [GOC:mah]
synonym: "dorsoventral lineage restriction, imaginal disc" EXACT [GOC:mah]
is_a: GO:0035161 ! imaginal disc lineage restriction
relationship: part_of GO:0007450 ! dorsal/ventral pattern formation, imaginal disc

[Term]
id: GO:0007453
name: clypeo-labral disc morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures derived from the clypeo-labral disc are generated and organized. This includes the transformation of a clypeo-labal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the labrum, anterior and posterior cibarial plates, fish trap bristles, epistomal sclerite and clypeus." [GOC:bf, ISBN:0879694238]
synonym: "clypeo-labral disc metamorphosis" EXACT []
synonym: "morphogenesis of structures derived from the clypeo-labral disc" EXACT []
is_a: GO:0007560 ! imaginal disc morphogenesis
relationship: part_of GO:0035213 ! clypeo-labral disc development

[Term]
id: GO:0007454
name: labial disc morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures derived from the labial disc are generated and organized. This includes the transformation of a labial imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including parts of the proboscis." [GOC:bf, ISBN:0879694238]
synonym: "labial disc metamorphosis" EXACT []
is_a: GO:0007560 ! imaginal disc morphogenesis
relationship: part_of GO:0035217 ! labial disc development

[Term]
id: GO:0007455
name: eye-antennal disc morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures derived from the eye-antennal disc are generated and organized. This includes the transformation of an eye-antennal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238]
synonym: "eye-antennal disc metamorphosis" EXACT []
is_a: GO:0007560 ! imaginal disc morphogenesis
relationship: part_of GO:0035214 ! eye-antennal disc development

[Term]
id: GO:0007458
name: progression of morphogenetic furrow involved in compound eye morphogenesis
namespace: biological_process
def: "The morphogenetic furrow is a dorsoventral indentation which sweeps anteriorly across the eye disc. Ommatidia begin to form along the furrow, resulting in a graded series of ommatidial development across the anterior/posterior axis of the disc." [PMID:3076112, PMID:3937883]
synonym: "progression of morphogenetic furrow during compound eye morphogenesis" RELATED [GOC:dph, GOC:tb]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0001745 ! compound eye morphogenesis

[Term]
id: GO:0007460
name: R8 cell fate commitment
namespace: biological_process
alt_id: GO:0007461
def: "The process in which the R8 photoreceptor commits to its cell fate. The R8 receptor contributes the central part of the rhabdomere in the basal parts of the ommatidium." [PMID:3076112, PMID:3937883]
synonym: "restriction of R8 fate" EXACT []
is_a: GO:0001752 ! compound eye photoreceptor fate commitment
relationship: part_of GO:0045465 ! R8 cell differentiation

[Term]
id: GO:0007462
name: R1/R6 cell fate commitment
namespace: biological_process
def: "The process in which the R1/R6 photoreceptors commit to their cell fate. R1 and R6 are paired photoreceptors which contribute the outer rhabdomeres." [PMID:3076112, PMID:3937883]
is_a: GO:0001752 ! compound eye photoreceptor fate commitment
relationship: part_of GO:0048052 ! R1/R6 cell differentiation

[Term]
id: GO:0007463
name: R2/R5 cell fate commitment
namespace: biological_process
def: "The process in which the R2/R5 photoreceptors commit to their cell fate. R2 and R5 are paired photoreceptors which contribute the outer rhabdomeres." [PMID:3076112, PMID:3937883]
is_a: GO:0001752 ! compound eye photoreceptor fate commitment
relationship: part_of GO:0048054 ! R2/R5 cell differentiation

[Term]
id: GO:0007464
name: R3/R4 cell fate commitment
namespace: biological_process
def: "The process in which the R3/R4 photoreceptors commit to their cell fate. R3 and R4 are paired photoreceptors which contribute the outer rhabdomeres." [PMID:3076112, PMID:3937883]
is_a: GO:0001752 ! compound eye photoreceptor fate commitment
relationship: part_of GO:0042067 ! establishment of ommatidial planar polarity
relationship: part_of GO:0048056 ! R3/R4 cell differentiation

[Term]
id: GO:0007465
name: R7 cell fate commitment
namespace: biological_process
def: "The process in which the R7 photoreceptor commits to its cell fate. The R7 receptor contributes the central part of the rhabdomere in the apical parts of the ommatidium." [PMID:3076112, PMID:3937883]
is_a: GO:0001752 ! compound eye photoreceptor fate commitment
relationship: part_of GO:0045466 ! R7 cell differentiation

[Term]
id: GO:0007468
name: regulation of rhodopsin gene expression
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of rhodopsin gene expression. This includes transcriptional, translational, or posttranslational regulation." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "regulation of rhodopsin gene activity" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010468 ! regulation of gene expression
relationship: part_of GO:0042461 ! photoreceptor cell development

[Term]
id: GO:0007469
name: antennal development
namespace: biological_process
def: "The process whose specific outcome is the progression of the antenna over time, from its formation to the mature structure. The antenna are the sensory structures on the head that are capable of detecting various environmental stimuli." [http://fly.ebi.ac.uk/.bin/cvreport2?id=FBcv0004526]
is_a: GO:0035114 ! imaginal disc-derived appendage morphogenesis
relationship: part_of GO:0035214 ! eye-antennal disc development

[Term]
id: GO:0007470
name: prothoracic disc morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures derived from the prothoracic disc are generated and organized. This includes the transformation of a prothoracic imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult humerous and anterior spiracle." [GOC:bf, ISBN:0879694238]
synonym: "prothoracic disc metamorphosis" EXACT []
is_a: GO:0007560 ! imaginal disc morphogenesis
relationship: part_of GO:0035219 ! prothoracic disc development

[Term]
id: GO:0007471
name: obsolete prothoracic morphogenesis
namespace: biological_process
def: "OBSOLETE. The process by which the anatomical structures of the first or anterior segment of the insect thorax are generated and organized." [GOC:jid]
comment: This term was made obsolete because it does not stipulate which anatomical part is involved in the process.
synonym: "prothoracic morphogenesis" EXACT []
is_obsolete: true
consider: GO:0007470

[Term]
id: GO:0007472
name: wing disc morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures derived from the wing disc are generated and organized. This includes the transformation of a wing imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
synonym: "wing disc metamorphosis" EXACT []
is_a: GO:0007560 ! imaginal disc morphogenesis
relationship: part_of GO:0035220 ! wing disc development

[Term]
id: GO:0007473
name: wing disc proximal/distal pattern formation
namespace: biological_process
def: "The establishment, maintenance and elaboration of the proximal/distal axis of the wing disc, a precursor to the adult wing." [GOC:bf]
is_a: GO:0007449 ! proximal/distal pattern formation, imaginal disc
is_a: GO:0035222 ! wing disc pattern formation

[Term]
id: GO:0007474
name: imaginal disc-derived wing vein specification
namespace: biological_process
def: "The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu]
synonym: "wing vein specification" EXACT []
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis

[Term]
id: GO:0007475
name: apposition of dorsal and ventral imaginal disc-derived wing surfaces
namespace: biological_process
def: "The coming together of the dorsal and ventral surfaces of the imaginal disc-derived wing during the conversion of a folded single layered wing disc to a flat bilayered wing." [GOC:bf, GOC:mtg_sensu]
synonym: "apposition of dorsal and ventral wing surfaces" EXACT []
is_a: GO:0009886 ! post-embryonic morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0008587 ! imaginal disc-derived wing margin morphogenesis

[Term]
id: GO:0007476
name: imaginal disc-derived wing morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
synonym: "wing morphogenesis" EXACT []
is_a: GO:0035114 ! imaginal disc-derived appendage morphogenesis
is_a: GO:0035120 ! post-embryonic appendage morphogenesis
relationship: part_of GO:0007472 ! wing disc morphogenesis

[Term]
id: GO:0007477
name: notum development
namespace: biological_process
def: "The process whose specific outcome is the progression of the dorsal part of the body over time, from its formation to the mature structure." [GOC:jid]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0035220 ! wing disc development

[Term]
id: GO:0007478
name: leg disc morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures derived from the leg disc are generated and organized. This includes the transformation of a leg imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the leg, coxa and ventral thoracic pleura." [GOC:bf, ISBN:0879694238]
synonym: "leg disc metamorphosis" EXACT []
is_a: GO:0007560 ! imaginal disc morphogenesis
relationship: part_of GO:0035218 ! leg disc development

[Term]
id: GO:0007479
name: leg disc proximal/distal pattern formation
namespace: biological_process
def: "The establishment, maintenance and elaboration of the proximal/distal axis of the leg imaginal disc, a precursor to the adult leg." [GOC:bf]
is_a: GO:0007449 ! proximal/distal pattern formation, imaginal disc
is_a: GO:0035223 ! leg disc pattern formation

[Term]
id: GO:0007480
name: imaginal disc-derived leg morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
is_a: GO:0035114 ! imaginal disc-derived appendage morphogenesis
is_a: GO:0035120 ! post-embryonic appendage morphogenesis
relationship: part_of GO:0007478 ! leg disc morphogenesis

[Term]
id: GO:0007481
name: haltere disc morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures derived from the haltere disc are generated and organized. This includes the transformation of a haltere imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult capitellum, pedicel, haltere sclerite, metathoracic spiracle and metanotum." [GOC:bf, ISBN:0879694238]
synonym: "haltere disc metamorphosis" EXACT []
is_a: GO:0007560 ! imaginal disc morphogenesis
relationship: part_of GO:0035216 ! haltere disc development

[Term]
id: GO:0007482
name: haltere development
namespace: biological_process
def: "The process whose specific outcome is the progression of the haltere over time, from its formation to the mature structure. The haltere is the club-shaped 'balancers' found on each side of the metathorax among the true flies (Diptera). They are the much-modified hind wings." [GOC:jid, http://www.earthlife.net]
is_a: GO:0048737 ! imaginal disc-derived appendage development
relationship: part_of GO:0035216 ! haltere disc development

[Term]
id: GO:0007483
name: genital disc morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures derived from the genital disc are generated and organized. This includes the transformation of a genital imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult genital structures, the anal plates and the hind gut." [GOC:bf, ISBN:0879694238]
synonym: "genital disc metamorphosis" EXACT []
is_a: GO:0007560 ! imaginal disc morphogenesis
relationship: part_of GO:0035215 ! genital disc development

[Term]
id: GO:0007484
name: imaginal disc-derived genitalia development
namespace: biological_process
def: "The process whose specific outcome is the progression of the genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster." [GOC:ai, GOC:sensu]
synonym: "genital development" BROAD []
is_a: GO:0048806 ! genitalia development
relationship: part_of GO:0035215 ! genital disc development

[Term]
id: GO:0007485
name: imaginal disc-derived male genitalia development
namespace: biological_process
def: "The process whose specific outcome is the progression of the male genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster." [GOC:ai, GOC:sensu]
synonym: "male genital development" BROAD []
is_a: GO:0007484 ! imaginal disc-derived genitalia development

[Term]
id: GO:0007486
name: imaginal disc-derived female genitalia development
namespace: biological_process
def: "The process whose specific outcome is the progression of the female genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster." [GOC:ai, GOC:sensu]
synonym: "female genital development" BROAD []
is_a: GO:0007484 ! imaginal disc-derived genitalia development
is_a: GO:0030540 ! female genitalia development

[Term]
id: GO:0007487
name: analia development
namespace: biological_process
def: "The process whose specific outcome is the progression of the analia over time, from its formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is analia development in Drosophila melanogaster." [GOC:ai, GOC:mtg_sensu]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0035215 ! genital disc development

[Term]
id: GO:0007488
name: histoblast morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures derived from the histoblast disc are generated and organized. This includes the transformation of histoblast cells into adult structures during pupal metamorphosis. Histoblast cells are cells founded in the embryo that are the progenitors to the adult abdomen." [GOC:bf, ISBN:0879694238]
synonym: "histoblast metamorphosis" EXACT []
is_a: GO:0007560 ! imaginal disc morphogenesis

[Term]
id: GO:0007489
name: maintenance of imaginal histoblast diploidy
namespace: biological_process
def: "The negative regulation of the differentiation of polytenized larval hypodermal cells from abdominal histoblasts. The abdominal histoblasts remain a small cluster of diploid cells among the polytenized larval hypodermal cells." [GOC:bf, ISBN:0879694238]
is_a: GO:0045596 ! negative regulation of cell differentiation
relationship: part_of GO:0007488 ! histoblast morphogenesis

[Term]
id: GO:0007490
name: tergite morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the tergite are generated and organized. The tergite is the primary plate or sclerite forming the dorsal surface of any insect body segment." [GOC:jid, http://www.earthlife.net]
is_a: GO:0009886 ! post-embryonic morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0007488 ! histoblast morphogenesis

[Term]
id: GO:0007491
name: sternite morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the sternite are generated and organized. The sternite is the plate or sclerite on the underside of a body segment." [GOC:jid, http://www.earthlife.net]
is_a: GO:0009886 ! post-embryonic morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0007488 ! histoblast morphogenesis

[Term]
id: GO:0007492
name: endoderm development
namespace: biological_process
def: "The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues." [GOC:dph, GOC:tb]
is_a: GO:0009888 ! tissue development

[Term]
id: GO:0007493
name: endodermal cell fate determination
namespace: biological_process
def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into an endoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators, ISBN:0878932437]
comment: Note that this term was 'endoderm determination'. Changed string to make it more consistent with parent term 'cell fate determination'.
synonym: "endoderm cell fate determination" EXACT []
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0001711 ! endodermal cell fate commitment

[Term]
id: GO:0007494
name: midgut development
namespace: biological_process
def: "The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine." [GOC:jid, UBERON:0001045]
is_a: GO:0048565 ! digestive tract development

[Term]
id: GO:0007495
name: visceral mesoderm-endoderm interaction involved in midgut development
namespace: biological_process
def: "The process of cell-cell signaling between visceral mesoderm cells and endoderm cells that is involved in the differentiation of cells in the midgut." [GOC:dph, GOC:isa_complete]
synonym: "visceral mesoderm/endoderm interaction" EXACT []
is_a: GO:0007267 ! cell-cell signaling
relationship: part_of GO:0007494 ! midgut development

[Term]
id: GO:0007496
name: anterior midgut development
namespace: biological_process
def: "The process whose specific outcome is the progression of the anterior midgut over time, from its formation to the mature structure." [GOC:jid]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007494 ! midgut development

[Term]
id: GO:0007497
name: posterior midgut development
namespace: biological_process
def: "The process whose specific outcome is the progression of the posterior midgut over time, from its formation to the mature structure." [GOC:go_curators]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007494 ! midgut development

[Term]
id: GO:0007498
name: mesoderm development
namespace: biological_process
def: "The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb]
is_a: GO:0009888 ! tissue development

[Term]
id: GO:0007499
name: ectoderm and mesoderm interaction
namespace: biological_process
def: "A cell-cell signaling process occurring between the two gastrulation-generated layers of the ectoderm and the mesoderm." [GOC:isa_complete]
synonym: "ectoderm/mesoderm interaction" EXACT []
is_a: GO:0007267 ! cell-cell signaling
relationship: part_of GO:0007498 ! mesoderm development

[Term]
id: GO:0007500
name: mesodermal cell fate determination
namespace: biological_process
def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators, ISBN:0878932437]
comment: Note that this term was 'mesoderm determination'. Changed string to make more consistent with parent term 'cell fate determination'.
synonym: "mesoderm cell fate determination" EXACT []
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0001710 ! mesodermal cell fate commitment

[Term]
id: GO:0007501
name: mesodermal cell fate specification
namespace: biological_process
def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators]
comment: Note that this term was 'fate specification in mesoderm'. String of term was changed to correspond to format of sibling terms 'endoderm cell fate specification' and 'ectoderm cell fate specification'.
synonym: "mesoderm cell fate specification" EXACT []
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0001710 ! mesodermal cell fate commitment

[Term]
id: GO:0007502
name: digestive tract mesoderm development
namespace: biological_process
def: "The process whose specific outcome is the progression of the digestive tract mesoderm over time, from its formation to the mature structure. The digestive tract mesoderm is portion of the middle layer of the three primary germ layers of the embryo which will go on to form part of the digestive tract of the organism." [GOC:ai]
is_a: GO:0009888 ! tissue development
relationship: part_of GO:0007498 ! mesoderm development
relationship: part_of GO:0048565 ! digestive tract development

[Term]
id: GO:0007503
name: fat body development
namespace: biological_process
def: "The process whose specific outcome is the progression of the fat body over time, from its formation to the mature structure. A fat body is an insect gland dorsal to the insect gut, with a function analogous to that of the vertebrate liver. It is a storage organ for fats, glycogen and protein and is a major site of intermediary metabolism." [ISBN:0582227089]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048513 ! animal organ development
is_a: GO:0060612 ! adipose tissue development

[Term]
id: GO:0007504
name: larval fat body development
namespace: biological_process
def: "The process whose specific outcome is the progression of the larval fat body over time, from its formation to the mature structure. The larval fat body consists of a bilaterally symmetrical monolayer of cells lying between the gut and the muscles of the body wall. As in other tissues of the larva, the cells of the fat body complete their divisions in the embryo and increase in size and ploidy during larval life." [GOC:bf, ISBN:0879694238]
is_a: GO:0007503 ! fat body development
is_a: GO:0048569 ! post-embryonic organ development
relationship: part_of GO:0002168 ! instar larval development

[Term]
id: GO:0007505
name: adult fat body development
namespace: biological_process
def: "The process whose specific outcome is the progression of the adult fat body over time, from its formation to the mature structure. Larval fat body cells that remain at eclosion degenerate in the first 2 to 4 days of adult life, leaving behind the smaller cells of the adult fat body." [GOC:bf, ISBN:0879694238]
is_a: GO:0007503 ! fat body development

[Term]
id: GO:0007506
name: gonadal mesoderm development
namespace: biological_process
def: "The process whose specific outcome is the progression of the gonadal mesoderm over time, from its formation to the mature structure. The gonadal mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gonads of the organism." [GOC:ai]
is_a: GO:0007498 ! mesoderm development
is_a: GO:0048608 ! reproductive structure development
is_a: GO:0060485 ! mesenchyme development
relationship: part_of GO:0008406 ! gonad development

[Term]
id: GO:0007507
name: heart development
namespace: biological_process
alt_id: GO:0007511
def: "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948]
synonym: "cardiac development" RELATED []
synonym: "dorsal vessel development" NARROW []
xref: Wikipedia:Heart_development
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048513 ! animal organ development
relationship: part_of GO:0072358 ! cardiovascular system development

[Term]
id: GO:0007508
name: larval heart development
namespace: biological_process
def: "The process whose specific outcome is the progression of the larval heart over time, from its formation to the mature structure. In Drosophila the larval heart (dorsal vessel) is a continuous tube of mesodormal cells that runs beneath the dorsal midline of the epidermis, divided into an anterior aorta and a posterior heart proper." [GOC:bf, ISBN:08779694238]
is_a: GO:0007507 ! heart development
is_a: GO:0048569 ! post-embryonic organ development
relationship: part_of GO:0002164 ! larval development

[Term]
id: GO:0007509
name: mesoderm migration involved in gastrulation
namespace: biological_process
def: "The migration of mesodermal cells during gastrulation to help establish the multilayered body plan of the organism." [GOC:isa_complete, GOC:sat]
is_a: GO:0008078 ! mesodermal cell migration
is_a: GO:0042074 ! cell migration involved in gastrulation
is_a: GO:0090130 ! tissue migration
relationship: part_of GO:0001707 ! mesoderm formation

[Term]
id: GO:0007510
name: cardioblast cell fate determination
namespace: biological_process
def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a cardioblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators]
is_a: GO:0060913 ! cardiac cell fate determination
relationship: part_of GO:0042684 ! cardioblast cell fate commitment

[Term]
id: GO:0007512
name: adult heart development
namespace: biological_process
def: "The process whose specific outcome is the progression of the adult heart over time, from its formation to the mature structure." [GOC:bf]
synonym: "adult cardiac development" RELATED []
is_a: GO:0007507 ! heart development

[Term]
id: GO:0007515
name: obsolete lymph gland development
namespace: biological_process
def: "OBSOLETE. The process whose specific outcome is the progression of the lymph gland over time, from its formation to the mature structure. The lymph gland is a small bean-shaped organ made up of a loose meshwork of reticular tissue in which are enmeshed large numbers of lymphocytes, macrophages and accessory cells. Lymph glands are located along the lymphatic system." [GOC:jid]
comment: This term was made obsolete because it was wrongly defined.
synonym: "lymph gland development" EXACT []
is_obsolete: true
consider: GO:0048535
consider: GO:0048542

[Term]
id: GO:0007516
name: hemocyte development
namespace: biological_process
def: "The process whose specific outcome is the progression of the hemocyte over time, from its formation to the mature structure. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu]
synonym: "arthropod blood cell development" EXACT []
is_a: GO:0048468 ! cell development
relationship: part_of GO:0042386 ! hemocyte differentiation

[Term]
id: GO:0007517
name: muscle organ development
namespace: biological_process
def: "The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732]
is_a: GO:0048513 ! animal organ development
is_a: GO:0061061 ! muscle structure development

[Term]
id: GO:0007518
name: myoblast fate determination
namespace: biological_process
def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a myoblast regardless of its environment; upon determination, the cell fate cannot be reversed. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:go_curators]
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0048625 ! myoblast fate commitment

[Term]
id: GO:0007519
name: skeletal muscle tissue development
namespace: biological_process
alt_id: GO:0048637
def: "The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers." [GOC:mtg_muscle]
synonym: "myogenesis" RELATED []
is_a: GO:0014706 ! striated muscle tissue development
relationship: part_of GO:0060538 ! skeletal muscle organ development

[Term]
id: GO:0007520
name: myoblast fusion
namespace: biological_process
def: "A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle]
is_a: GO:0000768 ! syncytium formation by plasma membrane fusion
relationship: part_of GO:0014902 ! myotube differentiation

[Term]
id: GO:0007521
name: muscle cell fate determination
namespace: biological_process
def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a muscle cell regardless of its environment; upon determination, the cell fate cannot be reversed." [CL:0000187, GOC:go_curators]
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0042693 ! muscle cell fate commitment

[Term]
id: GO:0007522
name: visceral muscle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the visceral muscle over time, from its formation to the mature structure." [GOC:go_curators]
is_a: GO:0007517 ! muscle organ development

[Term]
id: GO:0007523
name: larval visceral muscle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the larval visceral muscle over time, from its formation to the mature structure." [GOC:jid]
is_a: GO:0007522 ! visceral muscle development
is_a: GO:0048569 ! post-embryonic organ development
relationship: part_of GO:0002164 ! larval development

[Term]
id: GO:0007524
name: adult visceral muscle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the adult visceral muscle over time, from its formation to the mature structure." [GOC:jid]
is_a: GO:0007522 ! visceral muscle development

[Term]
id: GO:0007525
name: somatic muscle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. Somatic muscles are striated muscle structures that connect to the exoskeleton or cuticle." [GOC:jid, GOC:mtg_muscle]
is_a: GO:0061061 ! muscle structure development

[Term]
id: GO:0007526
name: larval somatic muscle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the larval somatic muscle over time, from its formation to the mature structure." [GOC:jid]
is_a: GO:0007525 ! somatic muscle development
is_a: GO:0048569 ! post-embryonic organ development
relationship: part_of GO:0002164 ! larval development

[Term]
id: GO:0007527
name: adult somatic muscle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the adult somatic muscle over time, from its formation to the mature structure." [GOC:jid]
is_a: GO:0007525 ! somatic muscle development

[Term]
id: GO:0007528
name: neuromuscular junction development
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013]
synonym: "neuromuscular junction organization" EXACT []
synonym: "neuromuscular junction stability" RELATED [GOC:pr]
synonym: "NMJ stability" RELATED [GOC:pr]
is_a: GO:0050808 ! synapse organization

[Term]
id: GO:0007529
name: establishment of synaptic specificity at neuromuscular junction
namespace: biological_process
def: "The biological process in which a synapse between a motor neuron and a muscle is initially formed." [GOC:isa_complete]
is_a: GO:0050808 ! synapse organization
relationship: part_of GO:0007528 ! neuromuscular junction development

[Term]
id: GO:0007530
name: sex determination
namespace: biological_process
def: "Any process that establishes and transmits the specification of sexual status of an individual organism." [ISBN:0198506732]
xref: Wikipedia:Sex-determination_system
is_a: GO:0003006 ! developmental process involved in reproduction

[Term]
id: GO:0007531
name: mating type determination
namespace: biological_process
def: "Any process that establishes and transmits the specification of mating type upon an individual. Mating types are the equivalent in microorganisms of the sexes in higher organisms." [http://www.biology-text.com/]
is_a: GO:0007530 ! sex determination
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0045165 ! cell fate commitment

[Term]
id: GO:0007532
name: regulation of mating-type specific transcription, DNA-templated
namespace: biological_process
def: "Any mating-type specific process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
synonym: "mating-type specific transcriptional control" EXACT []
synonym: "regulation of mating-type specific transcription, DNA-dependent" EXACT [GOC:txnOH]
is_a: GO:0006355 ! regulation of transcription, DNA-templated
is_a: GO:0007531 ! mating type determination

[Term]
id: GO:0007533
name: mating type switching
namespace: biological_process
def: "The conversion of a single-cell organism from one mating type to another by the precise replacement of a DNA sequence at the expressed mating type locus with a copy of a sequence from a donor locus." [PMID:9928492]
synonym: "mating type switching and recombination" RELATED []
is_a: GO:0007531 ! mating type determination
is_a: GO:0022413 ! reproductive process in single-celled organism
is_a: GO:0044710 ! single-organism metabolic process

[Term]
id: GO:0007534
name: gene conversion at mating-type locus
namespace: biological_process
def: "The conversion of the mating-type locus from one allele to another resulting from the recombinational repair of a site-specific double-strand break at the mating-type locus with information from a silent donor sequence. There is no reciprocal exchange of information because the mating-type locus copies information from the donor sequence and the donor sequence remains unchanged." [GOC:elh, PMID:9928492]
is_a: GO:0006312 ! mitotic recombination
is_a: GO:0022414 ! reproductive process
is_a: GO:0035822 ! gene conversion
relationship: part_of GO:0007533 ! mating type switching

[Term]
id: GO:0007535
name: donor selection
namespace: biological_process
def: "The process that determines which donor locus a cell uses, in preference to another, in mating type switching." [GOC:mah, PMID:9928492]
synonym: "donor preference" RELATED []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0048869 ! cellular developmental process
relationship: part_of GO:0007533 ! mating type switching

[Term]
id: GO:0007536
name: activation of recombination (HML)
namespace: biological_process
def: "The activation of recombination at a mating type locus, such that it is used in preference to the other donor locus for mating type switching; exemplified by the HML locus and surrounding sequences on Chromosome III in Saccharomyces cerevisiae." [GOC:mah, PMID:9928492]
is_a: GO:0007535 ! donor selection
is_a: GO:0045911 ! positive regulation of DNA recombination

[Term]
id: GO:0007537
name: inactivation of recombination (HML)
namespace: biological_process
def: "The inactivation of recombination at sequences around a mating type donor locus, with the consequence that the other donor is the only one available for mating type switching; exemplified by the HML locus and surrounding sequences on Chromosome III in Saccharomyces cerevisiae." [GOC:mah, PMID:9928492]
is_a: GO:0007535 ! donor selection
is_a: GO:0045910 ! negative regulation of DNA recombination

[Term]
id: GO:0007538
name: primary sex determination
namespace: biological_process
def: "The sex determination process that results in the initial specification of sexual status of an individual organism." [GOC:mah]
is_a: GO:0007530 ! sex determination
relationship: part_of GO:0007275 ! multicellular organism development

[Term]
id: GO:0007539
name: primary sex determination, soma
namespace: biological_process
def: "The transmission of information about sexual status from the initial, general, determination to signals specific to the soma." [GOC:ems]
is_a: GO:0007538 ! primary sex determination
relationship: part_of GO:0018993 ! somatic sex determination

[Term]
id: GO:0007540
name: sex determination, establishment of X:A ratio
namespace: biological_process
def: "The developmental process in which an organism senses the number of X chromosomes and autosomes in its genomic complement and responds to it." [GOC:isa_complete]
is_a: GO:0003006 ! developmental process involved in reproduction
relationship: part_of GO:0007539 ! primary sex determination, soma

[Term]
id: GO:0007541
name: sex determination, primary response to X:A ratio
namespace: biological_process
def: "The developmental process in which an organism interprets its X to autosomal chromosomal complement." [GOC:isa_complete]
is_a: GO:0003006 ! developmental process involved in reproduction
relationship: part_of GO:0007539 ! primary sex determination, soma

[Term]
id: GO:0007542
name: primary sex determination, germ-line
namespace: biological_process
def: "The transmission of information about sexual status, from the initial general determination, to signals specific to the germ-line." [GOC:ems]
is_a: GO:0007538 ! primary sex determination
relationship: part_of GO:0018992 ! germ-line sex determination

[Term]
id: GO:0007543
name: sex determination, somatic-gonadal interaction
namespace: biological_process
def: "The process that mediates the interactions between somatic cells and gonadal cells that ultimately results in the specification of sexual status of the organism." [GOC:isa_complete]
synonym: "sex determination, somatic/gonadal interaction" EXACT []
is_a: GO:0007154 ! cell communication
is_a: GO:0044702 ! single organism reproductive process
relationship: part_of GO:0007542 ! primary sex determination, germ-line

[Term]
id: GO:0007545
name: processes downstream of sex determination signal
namespace: biological_process
def: "The sex determination processes that take place after the initial transmission of the sexual phenotype to specific information pathways." [GOC:mah]
is_a: GO:0007530 ! sex determination
relationship: part_of GO:0007275 ! multicellular organism development

[Term]
id: GO:0007546
name: somatic processes downstream of sex determination signal
namespace: biological_process
def: "The events determining the somatic sexual phenotype after the initial transmission of that phenotype to soma-specific information pathways." [GOC:ems]
is_a: GO:0007545 ! processes downstream of sex determination signal

[Term]
id: GO:0007547
name: germ-line processes downstream of sex determination signal
namespace: biological_process
def: "The events determining the germ-line sexual phenotype after the initial transmission of that phenotype to germ-line-specific information pathways." [GOC:ems]
is_a: GO:0007545 ! processes downstream of sex determination signal
relationship: part_of GO:0018992 ! germ-line sex determination

[Term]
id: GO:0007548
name: sex differentiation
namespace: biological_process
def: "The establishment of the sex of an organism by physical differentiation." [GOC:ai]
xref: Wikipedia:Sexual_differentiation
is_a: GO:0003006 ! developmental process involved in reproduction

[Term]
id: GO:0007549
name: dosage compensation
namespace: biological_process
def: "Compensating for the two-fold variation in X:autosome chromosome ratios between sexes by a global activation or inactivation of all, or most of, genes on one or both of the X chromosomes." [GOC:ems, ISBN:0140512888, PMID:11498577]
xref: Wikipedia:Dosage_compensation
is_a: GO:0040029 ! regulation of gene expression, epigenetic

[Term]
id: GO:0007550
name: obsolete establishment of dosage compensation
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:isa_complete]
comment: This term was made obsolete because it was undefined and because there is no common mechanism of establishment of dosage compensation in different organisms.
synonym: "establishment of dosage compensation" EXACT []
is_obsolete: true
consider: GO:0007549

[Term]
id: GO:0007551
name: obsolete maintenance of dosage compensation
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:isa_complete]
comment: This term was made obsolete because it was undefined and because there is no common mechanism of establishment of dosage compensation in different organisms.
synonym: "maintenance of dosage compensation" EXACT []
is_obsolete: true
consider: GO:0007549

[Term]
id: GO:0007552
name: metamorphosis
namespace: biological_process
alt_id: GO:0046698
alt_id: GO:0046699
def: "A biological process in which an animal physically develops after birth or hatching, involving a conspicuous and relatively abrupt change in the animal's form or structure. Examples include the change from tadpole to frog, and the change from larva to adult. An example of this is found in Drosophila melanogaster." [GOC:sensu, ISBN:0198506732, ISBN:0721662544]
xref: Wikipedia:Metamorphosis
is_a: GO:0007275 ! multicellular organism development

[Term]
id: GO:0007553
name: regulation of ecdysteroid metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development, including the metamorphosis of immature forms and the development of the reproductive system and the maturation of oocytes in adult females." [ISBN:0198506732]
synonym: "regulation of ecdysteroid metabolism" EXACT []
is_a: GO:0010565 ! regulation of cellular ketone metabolic process
is_a: GO:0019218 ! regulation of steroid metabolic process
is_a: GO:0032350 ! regulation of hormone metabolic process
is_a: GO:0048580 ! regulation of post-embryonic development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045455 ! ecdysteroid metabolic process
relationship: regulates GO:0045455 ! ecdysteroid metabolic process

[Term]
id: GO:0007554
name: regulation of ecdysteroid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ecdysteroids." [GOC:go_curators]
synonym: "regulation of ecdysteroid anabolism" EXACT []
synonym: "regulation of ecdysteroid biosynthesis" EXACT []
synonym: "regulation of ecdysteroid formation" EXACT []
synonym: "regulation of ecdysteroid synthesis" EXACT []
is_a: GO:0007553 ! regulation of ecdysteroid metabolic process
is_a: GO:0010566 ! regulation of ketone biosynthetic process
is_a: GO:0090030 ! regulation of steroid hormone biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045456 ! ecdysteroid biosynthetic process
relationship: regulates GO:0045456 ! ecdysteroid biosynthetic process

[Term]
id: GO:0007555
name: regulation of ecdysteroid secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of ecdysteroid from a cell." [GOC:go_curators]
is_a: GO:2000831 ! regulation of steroid hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045457 ! ecdysteroid secretion
relationship: regulates GO:0045457 ! ecdysteroid secretion

[Term]
id: GO:0007556
name: regulation of juvenile hormone metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving juvenile hormone." [GOC:go_curators]
synonym: "regulation of juvenile hormone metabolism" EXACT []
is_a: GO:0019747 ! regulation of isoprenoid metabolic process
is_a: GO:0032350 ! regulation of hormone metabolic process
is_a: GO:0043455 ! regulation of secondary metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006716 ! juvenile hormone metabolic process
relationship: part_of GO:0002165 ! instar larval or pupal development
relationship: regulates GO:0006716 ! juvenile hormone metabolic process

[Term]
id: GO:0007557
name: regulation of juvenile hormone biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of juvenile hormone." [GOC:go_curators]
synonym: "regulation of juvenile hormone anabolism" EXACT []
synonym: "regulation of juvenile hormone biosynthesis" EXACT []
synonym: "regulation of juvenile hormone formation" EXACT []
synonym: "regulation of juvenile hormone synthesis" EXACT []
is_a: GO:0007556 ! regulation of juvenile hormone metabolic process
is_a: GO:0046885 ! regulation of hormone biosynthetic process
is_a: GO:0046890 ! regulation of lipid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006718 ! juvenile hormone biosynthetic process
relationship: regulates GO:0006718 ! juvenile hormone biosynthetic process

[Term]
id: GO:0007558
name: regulation of juvenile hormone secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of juvenile hormone secretion." [GOC:go_curators]
is_a: GO:0032368 ! regulation of lipid transport
is_a: GO:0044060 ! regulation of endocrine process
is_a: GO:0046883 ! regulation of hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045443 ! juvenile hormone secretion
relationship: regulates GO:0045443 ! juvenile hormone secretion

[Term]
id: GO:0007559
name: obsolete histolysis
namespace: biological_process
def: "OBSOLETE. The breakdown of tissues; usually, if not always, accompanied by cell death, followed by the complete dissolution of dead tissue." [GOC:dph, GOC:ma]
comment: This term was made obsolete because it refers to a phenotype. When death of a cell or tissue is a result of a true biological process, this should be captured using 'programmed cell death' or one of its descendants.
xref: Wikipedia:Histolysis
is_obsolete: true
consider: GO:0008219
consider: GO:0012501

[Term]
id: GO:0007560
name: imaginal disc morphogenesis
namespace: biological_process
alt_id: GO:0007452
def: "The process in which the anatomical structures derived from an imaginal disc are generated and organized. The imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult appendages (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:jid]
synonym: "imaginal disc metamorphosis" EXACT []
is_a: GO:0048563 ! post-embryonic organ morphogenesis
is_a: GO:0060562 ! epithelial tube morphogenesis
relationship: part_of GO:0007444 ! imaginal disc development
relationship: part_of GO:0007552 ! metamorphosis
relationship: part_of GO:0048707 ! instar larval or pupal morphogenesis

[Term]
id: GO:0007561
name: imaginal disc eversion
namespace: biological_process
def: "The eversion (turning inside out) of imaginal discs from their peripodial sacs, resulting in movement of the epithelium to the outside of the larval epidermis." [PMID:11494317]
is_a: GO:0009886 ! post-embryonic morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0007560 ! imaginal disc morphogenesis

[Term]
id: GO:0007562
name: eclosion
namespace: biological_process
def: "The emergence of an adult insect from a pupa case." [GOC:dgh, GOC:dos, GOC:mah, ISBN:0198600461]
xref: Wikipedia:Pupa#Emergence
is_a: GO:0071684 ! organism emergence from protective structure
relationship: part_of GO:0007275 ! multicellular organism development

[Term]
id: GO:0007563
name: regulation of eclosion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the emergence of an insect from a pupa-case or of a larva from an egg." [GOC:go_curators, ISBN:0198600461]
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007562 ! eclosion
relationship: regulates GO:0007562 ! eclosion

[Term]
id: GO:0007564
name: regulation of chitin-based cuticle tanning
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chitin-based cuticular tanning." [GOC:go_curators, GOC:jid, GOC:mtg_sensu]
synonym: "regulation of cuticle hardening" NARROW []
synonym: "regulation of cuticle tanning" EXACT []
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007593 ! chitin-based cuticle sclerotization
relationship: regulates GO:0007593 ! chitin-based cuticle sclerotization

[Term]
id: GO:0007565
name: female pregnancy
namespace: biological_process
def: "The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth." [ISBN:0192800825]
subset: goslim_chembl
synonym: "carrying of young" RELATED []
synonym: "gestation" EXACT []
xref: Wikipedia:Gestation
is_a: GO:0044703 ! multi-organism reproductive process
is_a: GO:0044706 ! multi-multicellular organism process

[Term]
id: GO:0007566
name: embryo implantation
namespace: biological_process
def: "Attachment of the blastocyst to the uterine lining." [GOC:isa_complete, http://www.medterms.com]
synonym: "blastocyst implantation" EXACT []
is_a: GO:0044702 ! single organism reproductive process
relationship: part_of GO:0007275 ! multicellular organism development
relationship: part_of GO:0007565 ! female pregnancy

[Term]
id: GO:0007567
name: parturition
namespace: biological_process
def: "The reproductive process in which the parent is separated from its offspring either by giving birth to live young or by laying eggs." [ISBN:0198506732]
synonym: "egg laying" NARROW []
synonym: "giving birth" EXACT []
is_a: GO:0044703 ! multi-organism reproductive process
is_a: GO:0044706 ! multi-multicellular organism process

[Term]
id: GO:0007568
name: aging
namespace: biological_process
alt_id: GO:0016280
def: "A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700)." [GOC:PO_curators]
subset: goslim_chembl
subset: goslim_generic
synonym: "ageing" EXACT []
xref: Wikipedia:Aging
is_a: GO:0044767 ! single-organism developmental process

[Term]
id: GO:0007569
name: cell aging
namespace: biological_process
def: "An aging process that has as participant a cell after a cell has stopped dividing. Cell aging may occur when a cell has temporarily stopped dividing through cell cycle arrest (GO:0007050) or when a cell has permanently stopped dividing, in which case it is undergoing cellular senescence (GO:0090398). May precede cell death (GO:0008219) and succeed cell maturation (GO:0048469)." [GOC:PO_curators]
synonym: "cell ageing" EXACT []
is_a: GO:0007568 ! aging
is_a: GO:0048869 ! cellular developmental process

[Term]
id: GO:0007570
name: obsolete age dependent accumulation of genetic damage
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it does not describe a biological process.
synonym: "age dependent accumulation of genetic damage" EXACT []
is_obsolete: true
consider: GO:0001301

[Term]
id: GO:0007571
name: age-dependent general metabolic decline
namespace: biological_process
def: "A developmental process that arises as the cell progresses toward the end of its lifespan and cause changes cellular metabolism, resulting in a decline in cell function; for example, one aspect of general metabolic decline is a decrease in the efficiency of protein synthesis." [GOC:jh, GOC:mah, PMID:9891807]
synonym: "age-dependent decreased translational activity" NARROW []
synonym: "age-dependent increased protein content" NARROW []
synonym: "age-dependent yeast cell size increase" RELATED []
synonym: "nucleolar size increase" NARROW []
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0007568 ! aging

[Term]
id: GO:0007572
name: obsolete age dependent decreased translational activity
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it does not describe a biological process.
synonym: "age dependent decreased translational activity" EXACT []
is_obsolete: true
consider: GO:0007571

[Term]
id: GO:0007573
name: obsolete age dependent increased protein content
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it does not describe a biological process.
synonym: "age dependent increased protein content" EXACT []
is_obsolete: true
consider: GO:0007571

[Term]
id: GO:0007574
name: obsolete cell aging (sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. Process associated with continued cell division (budding) by the mother cell. Age is often measured by counting the number of bud scars on the cell." [GOC:sgd_curators]
comment: This term was made obsolete because it does not describe a biological process that is distinct from 'cell aging'.
synonym: "cell aging (sensu Saccharomyces)" EXACT []
is_obsolete: true
replaced_by: GO:0007569

[Term]
id: GO:0007575
name: obsolete nucleolar size increase
namespace: biological_process
def: "OBSOLETE. The process of nucleolar expansion." [GOC:ai]
comment: This term was made obsolete because it does not describe a biological process.
synonym: "nucleolar size increase" EXACT []
is_obsolete: true
consider: GO:0007571
consider: GO:0007576

[Term]
id: GO:0007576
name: nucleolar fragmentation
namespace: biological_process
alt_id: GO:0046616
def: "The cell aging process that results in the nucleolus breaking down into fragments." [GOC:mah, PMID:9271578]
synonym: "nucleolar size increase" RELATED []
is_a: GO:0007000 ! nucleolus organization
relationship: part_of GO:0007569 ! cell aging

[Term]
id: GO:0007577
name: obsolete autophagic death (sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. This process is a type of programmed cell death pathway similar to apoptosis and necrosis observed in multicellular organisms. It is characterized by cellular enlargement (necrosis) and presence of many autophagic bodies along with degradation of cellular components (nucleus, Golgi, ER), protein, DNA and RNA." [GOC:sgd_curators]
comment: This term was made obsolete because a more correct term has been created.
synonym: "autophagic death (sensu Saccharomyces)" EXACT []
is_obsolete: true
consider: GO:0048102

[Term]
id: GO:0007578
name: obsolete aging dependent sterility (sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. A haploid's inability to mate due to the loss of silencing at the mating-type loci, resulting in expression of both of the normally silent mating-type cassettes." [GOC:sgd_curators]
comment: This term was made obsolete because it reflected a trait or phenotype.
synonym: "aging dependent sterility (sensu Saccharomyces)" EXACT []
is_obsolete: true
consider: GO:0030466

[Term]
id: GO:0007579
name: obsolete senescence factor accumulation
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jh]
comment: This term was made obsolete because it does not represent a process.
synonym: "senescence factor accumulation" EXACT []
is_obsolete: true

[Term]
id: GO:0007580
name: extrachromosomal circular DNA accumulation involved in cell aging
namespace: biological_process
def: "Increase in abundance, as cells age, of circular DNA molecules that originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and replicated independently of chromosomal replication." [GOC:jh, PMID:9891807]
comment: Note that the term string was changed to be consistent with placement of this term in cell aging hierarchy.
synonym: "extrachromosomal circular DNA accumulation during cell ageing" RELATED []
synonym: "extrachromosomal circular DNA accumulation during cell aging" RELATED [GOC:dph, GOC:tb]
is_a: GO:0001301 ! progressive alteration of chromatin involved in cell aging

[Term]
id: GO:0007581
name: obsolete age-dependent yeast cell size increase
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:sgd_curators]
comment: This term was made obsolete because it does not describe a biological process.
synonym: "age-dependent yeast cell size increase" EXACT []
is_obsolete: true
consider: GO:0007571

[Term]
id: GO:0007583
name: obsolete killer activity
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it is ambiguous; 'killer activity' could refer to several different processes.
synonym: "killer activity" EXACT []
is_obsolete: true
consider: GO:0042267

[Term]
id: GO:0007584
name: response to nutrient
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus." [GOC:go_curators]
subset: gosubset_prok
synonym: "nutritional response pathway" NARROW []
synonym: "response to nutrients" EXACT []
is_a: GO:0031667 ! response to nutrient levels
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0007585
name: respiratory gaseous exchange
namespace: biological_process
def: "The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms." [ISBN:0198506732]
subset: goslim_chembl
synonym: "breathing" BROAD []
synonym: "respiration" BROAD []
is_a: GO:0044707 ! single-multicellular organism process

[Term]
id: GO:0007586
name: digestion
namespace: biological_process
def: "The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, ISBN:0198506732]
subset: goslim_chembl
subset: goslim_pir
xref: Wikipedia:Digestion
is_a: GO:0044707 ! single-multicellular organism process

[Term]
id: GO:0007588
name: excretion
namespace: biological_process
def: "The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds." [ISBN:0192801023]
subset: goslim_pir
xref: Wikipedia:Excretion
is_a: GO:0003008 ! system process

[Term]
id: GO:0007589
name: body fluid secretion
namespace: biological_process
def: "The controlled release of a fluid by a cell or tissue in an animal." [GOC:ai, GOC:dph, GOC:mah, GOC:tb]
is_a: GO:0046903 ! secretion
is_a: GO:0050878 ! regulation of body fluid levels

[Term]
id: GO:0007590
name: obsolete fat body metabolic process (sensu Insecta)
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving the fat body. A fat body is a fat-containing cellular structure which serves as an energy reserve. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557)." [GOC:go_curators, ISBN:0198506732]
comment: This term was made obsolete because it represents metabolism within the fat body not of the fat body.
synonym: "fat body metabolic process (sensu Insecta)" EXACT []
is_obsolete: true
consider: GO:0008152
consider: GO:0015032

[Term]
id: GO:0007591
name: molting cycle, chitin-based cuticle
namespace: biological_process
def: "The periodic shedding of part or all of a chitin-based cuticle, which is then replaced by a new cuticle. An example of this is found in Drosophila melanogaster." [GOC:jl, GOC:mtg_sensu]
synonym: "chitin-based cuticle molting cycle" EXACT [GOC:dph, GOC:tb]
is_a: GO:0042303 ! molting cycle

[Term]
id: GO:0007592
name: obsolete protein-based cuticle development
namespace: biological_process
def: "OBSOLETE. Synthesis and deposition of a protein-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this is found in Caenorhabditis elegans." [GOC:ems, GOC:mtg_sensu]
comment: This term was made obsolete because 'protein-based cuticle' is an unnecessary grouping term.
synonym: "protein-based cuticle anabolism" EXACT []
synonym: "protein-based cuticle biosynthetic process" EXACT []
synonym: "protein-based cuticle development" EXACT []
synonym: "protein-based cuticle formation" EXACT []
synonym: "protein-based cuticle synthesis" EXACT []
is_obsolete: true
consider: GO:0040002
consider: GO:0040003

[Term]
id: GO:0007593
name: chitin-based cuticle sclerotization
namespace: biological_process
alt_id: GO:0045452
def: "The process of hardening of a chitin-based cuticle." [GOC:dos, GOC:mtg_sensu]
synonym: "chitin-based cuticle tanning" RELATED [GOC:bf, GOC:dos, GOC:sart]
synonym: "cuticle hardening" NARROW []
is_a: GO:0007591 ! molting cycle, chitin-based cuticle
is_a: GO:0021700 ! developmental maturation
is_a: GO:0022404 ! molting cycle process

[Term]
id: GO:0007594
name: puparial adhesion
namespace: biological_process
def: "The adhesion of the puparia of Diptera to their substrate; normally effected by a 'glue' secreted by the larval salivary gland and expectorated at the time of pupariation." [GOC:ma]
synonym: "puparial glue" RELATED []
is_a: GO:0022609 ! multicellular organism adhesion to substrate
relationship: part_of GO:0007591 ! molting cycle, chitin-based cuticle

[Term]
id: GO:0007595
name: lactation
namespace: biological_process
def: "The secretion of milk by the mammary gland." [ISBN:0198506732]
xref: Wikipedia:Lactation
is_a: GO:0007589 ! body fluid secretion
is_a: GO:0032941 ! secretion by tissue
relationship: part_of GO:0030879 ! mammary gland development

[Term]
id: GO:0007596
name: blood coagulation
namespace: biological_process
def: "The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers." [http://www.graylab.ac.uk/omd/, ISBN:0198506732]
synonym: "blood clotting" EXACT []
xref: Reactome:REACT_101311 "Hemostasis, Plasmodium falciparum"
xref: Reactome:REACT_101372 "Common Pathway, Danio rerio"
xref: Reactome:REACT_102544 "Common Pathway, Rattus norvegicus"
xref: Reactome:REACT_102650 "Common Pathway, Mus musculus"
xref: Reactome:REACT_105166 "Common Pathway, Taeniopygia guttata"
xref: Reactome:REACT_105212 "Common Pathway, Sus scrofa"
xref: Reactome:REACT_107268 "Hemostasis, Saccharomyces cerevisiae"
xref: Reactome:REACT_108583 "Hemostasis, Danio rerio"
xref: Reactome:REACT_113650 "Common Pathway, Drosophila melanogaster"
xref: Reactome:REACT_114152 "Formation of Fibrin Clot (Clotting Cascade), Drosophila melanogaster"
xref: Reactome:REACT_118351 "Hemostasis, Escherichia coli"
xref: Reactome:REACT_1439 "Common Pathway, Homo sapiens"
xref: Reactome:REACT_2051 "Formation of Fibrin Clot (Clotting Cascade), Homo sapiens"
xref: Reactome:REACT_32530 "Hemostasis, Xenopus tropicalis"
xref: Reactome:REACT_32765 "Hemostasis, Mycobacterium tuberculosis"
xref: Reactome:REACT_33270 "Hemostasis, Canis familiaris"
xref: Reactome:REACT_34525 "Hemostasis, Arabidopsis thaliana"
xref: Reactome:REACT_604 "Hemostasis, Homo sapiens"
xref: Reactome:REACT_76944 "Common Pathway, Canis familiaris"
xref: Reactome:REACT_78290 "Hemostasis, Staphylococcus aureus N315"
xref: Reactome:REACT_81054 "Formation of Fibrin Clot (Clotting Cascade), Canis familiaris"
xref: Reactome:REACT_81972 "Formation of Fibrin Clot (Clotting Cascade), Taeniopygia guttata"
xref: Reactome:REACT_82283 "Formation of Fibrin Clot (Clotting Cascade), Mus musculus"
xref: Reactome:REACT_82383 "Hemostasis, Oryza sativa"
xref: Reactome:REACT_82403 "Hemostasis, Rattus norvegicus"
xref: Reactome:REACT_82445 "Formation of Fibrin Clot (Clotting Cascade), Sus scrofa"
xref: Reactome:REACT_82812 "Hemostasis, Bos taurus"
xref: Reactome:REACT_82940 "Common Pathway, Xenopus tropicalis"
xref: Reactome:REACT_83271 "Hemostasis, Dictyostelium discoideum"
xref: Reactome:REACT_84055 "Formation of Fibrin Clot (Clotting Cascade), Danio rerio"
xref: Reactome:REACT_84833 "Formation of Fibrin Clot (Clotting Cascade), Rattus norvegicus"
xref: Reactome:REACT_85674 "Hemostasis, Sus scrofa"
xref: Reactome:REACT_86354 "Common Pathway, Gallus gallus"
xref: Reactome:REACT_89750 "Hemostasis, Mus musculus"
xref: Reactome:REACT_89805 "Formation of Fibrin Clot (Clotting Cascade), Xenopus tropicalis"
xref: Reactome:REACT_90236 "Hemostasis, Taeniopygia guttata"
xref: Reactome:REACT_90805 "Hemostasis, Caenorhabditis elegans"
xref: Reactome:REACT_92318 "Hemostasis, Drosophila melanogaster"
xref: Reactome:REACT_94085 "Hemostasis, Schizosaccharomyces pombe"
xref: Reactome:REACT_94213 "Common Pathway, Bos taurus"
xref: Reactome:REACT_94315 "Formation of Fibrin Clot (Clotting Cascade), Bos taurus"
xref: Reactome:REACT_94798 "Formation of Fibrin Clot (Clotting Cascade), Gallus gallus"
xref: Reactome:REACT_96458 "Hemostasis, Gallus gallus"
xref: Wikipedia:Coagulation
is_a: GO:0007599 ! hemostasis
is_a: GO:0050817 ! coagulation
relationship: part_of GO:0042060 ! wound healing

[Term]
id: GO:0007597
name: blood coagulation, intrinsic pathway
namespace: biological_process
def: "A protein activation cascade that contributes to blood coagulation and consists of the interactions among high molecular weight kininogen, prekallikrein, and factor XII that lead to the activation of clotting factor X." [GOC:add, GOC:mah, GOC:pde]
comment: See also the biological process term 'blood coagulation, extrinsic pathway ; GO:0007598'.
xref: Reactome:REACT_102838 "Intrinsic Pathway, Bos taurus"
xref: Reactome:REACT_103430 "Intrinsic Pathway, Xenopus tropicalis"
xref: Reactome:REACT_326 "Intrinsic Pathway, Homo sapiens"
xref: Reactome:REACT_77922 "Intrinsic Pathway, Taeniopygia guttata"
xref: Reactome:REACT_81963 "Intrinsic Pathway, Danio rerio"
xref: Reactome:REACT_84709 "Intrinsic Pathway, Gallus gallus"
xref: Reactome:REACT_90525 "Intrinsic Pathway, Rattus norvegicus"
xref: Reactome:REACT_95488 "Intrinsic Pathway, Sus scrofa"
xref: Reactome:REACT_95540 "Intrinsic Pathway, Mus musculus"
xref: Reactome:REACT_99138 "Intrinsic Pathway, Canis familiaris"
is_a: GO:0072376 ! protein activation cascade
relationship: part_of GO:0072378 ! blood coagulation, fibrin clot formation

[Term]
id: GO:0007598
name: blood coagulation, extrinsic pathway
namespace: biological_process
def: "A protein activation cascade that contributes to blood coagulation and consists of the self-limited process linking exposure and activation of tissue factor to the activation of clotting factor X." [GOC:add, GOC:mah, GOC:pde]
comment: See also the biological process term 'blood coagulation, intrinsic pathway ; GO:0007597'.
xref: Reactome:REACT_103431 "Extrinsic Pathway, Taeniopygia guttata"
xref: Reactome:REACT_105484 "Extrinsic Pathway, Mus musculus"
xref: Reactome:REACT_106178 "Extrinsic Pathway, Bos taurus"
xref: Reactome:REACT_106402 "Extrinsic Pathway, Xenopus tropicalis"
xref: Reactome:REACT_108118 "Extrinsic Pathway, Danio rerio"
xref: Reactome:REACT_1573 "Extrinsic Pathway, Homo sapiens"
xref: Reactome:REACT_86552 "Extrinsic Pathway, Rattus norvegicus"
xref: Reactome:REACT_86725 "Extrinsic Pathway, Canis familiaris"
xref: Reactome:REACT_95973 "Extrinsic Pathway, Gallus gallus"
is_a: GO:0072376 ! protein activation cascade
relationship: part_of GO:0072378 ! blood coagulation, fibrin clot formation

[Term]
id: GO:0007599
name: hemostasis
namespace: biological_process
def: "The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part." [ISBN:0198506732]
xref: Wikipedia:Hemostasis
is_a: GO:0050878 ! regulation of body fluid levels

[Term]
id: GO:0007600
name: sensory perception
namespace: biological_process
def: "The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai, GOC:dph]
xref: Wikipedia:Perception
is_a: GO:0050877 ! neurological system process

[Term]
id: GO:0007601
name: visual perception
namespace: biological_process
def: "The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai]
synonym: "sense of sight" EXACT []
synonym: "sensory visual perception" EXACT []
synonym: "vision" EXACT []
xref: Wikipedia:Visual_perception
is_a: GO:0050953 ! sensory perception of light stimulus

[Term]
id: GO:0007602
name: phototransduction
namespace: biological_process
def: "The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]
subset: gosubset_prok
synonym: "opsin" RELATED []
synonym: "phototransduction, visible light, light adaptation" NARROW []
synonym: "phototrophin mediated phototransduction" NARROW []
xref: Wikipedia:Visual_phototransduction
is_a: GO:0007165 ! signal transduction
is_a: GO:0009583 ! detection of light stimulus

[Term]
id: GO:0007603
name: phototransduction, visible light
namespace: biological_process
def: "The sequence of reactions within a cell required to convert absorbed photons from visible light into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm." [GOC:go_curators, ISBN:0198506732]
synonym: "visual cascade" EXACT [PMID:1962207, PMID:9822721]
synonym: "visual transduction" EXACT [PMID:10611962]
is_a: GO:0007602 ! phototransduction
is_a: GO:0009584 ! detection of visible light

[Term]
id: GO:0007604
name: phototransduction, UV
namespace: biological_process
def: "The sequence of reactions within a cell required to convert absorbed photons from UV light into a molecular signal; ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 400 nanometers." [GOC:go_curators, ISBN:0198506732]
synonym: "phototransduction, ultraviolet light" EXACT []
synonym: "phototransduction, ultraviolet radiation" EXACT []
synonym: "phototransduction, UV light" EXACT []
synonym: "phototransduction, UV radiation" EXACT []
synonym: "UV-sensitive opsin" RELATED []
is_a: GO:0007602 ! phototransduction
is_a: GO:0009589 ! detection of UV
is_a: GO:0034644 ! cellular response to UV

[Term]
id: GO:0007605
name: sensory perception of sound
namespace: biological_process
def: "The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai]
synonym: "hearing" EXACT []
synonym: "perception of sound" EXACT []
xref: Wikipedia:Hearing_(sense)
is_a: GO:0050954 ! sensory perception of mechanical stimulus

[Term]
id: GO:0007606
name: sensory perception of chemical stimulus
namespace: biological_process
def: "The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
synonym: "chemosensory perception" EXACT []
is_a: GO:0007600 ! sensory perception

[Term]
id: GO:0007607
name: obsolete taste perception
namespace: biological_process
def: "OBSOLETE. The series of events required for the chemical composition of a soluble stimulus to be received and converted to a molecular signal." [GOC:jl, ISBN:0395825172]
comment: This term was made obsolete because it was not clear whether the term applied to the whole process of taste perception or just the sensory transduction stage.
synonym: "taste perception" EXACT []
is_obsolete: true
consider: GO:0050909
consider: GO:0050912

[Term]
id: GO:0007608
name: sensory perception of smell
namespace: biological_process
def: "The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]
synonym: "olfaction" EXACT []
synonym: "scent perception" EXACT []
synonym: "sense of smell" EXACT []
synonym: "smell perception" EXACT []
xref: Wikipedia:Olfaction
is_a: GO:0007606 ! sensory perception of chemical stimulus

[Term]
id: GO:0007610
name: behavior
namespace: biological_process
def: "The internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." [GOC:ems, GOC:jl, ISBN:0395448956, PMID:20160973]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
subset: goslim_plant
subset: gosubset_prok
synonym: "behavioral response to stimulus" EXACT []
synonym: "behaviour" EXACT []
synonym: "behavioural response to stimulus" EXACT []
xref: Wikipedia:Behavior
is_a: GO:0008150 ! biological_process
disjoint_from: GO:0032502 ! developmental process

[Term]
id: GO:0007611
name: learning or memory
namespace: biological_process
def: "The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jid, PMID:8938125]
is_a: GO:0044707 ! single-multicellular organism process
is_a: GO:0044708 ! single-organism behavior
is_a: GO:0050890 ! cognition

[Term]
id: GO:0007612
name: learning
namespace: biological_process
def: "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience." [ISBN:0582227089, ISBN:0721662544]
xref: Wikipedia:Learning
is_a: GO:0007611 ! learning or memory

[Term]
id: GO:0007613
name: memory
namespace: biological_process
def: "The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task)." [GOC:curators, http://www.onelook.com/, ISBN:0582227089]
xref: Wikipedia:Memory
is_a: GO:0007611 ! learning or memory

[Term]
id: GO:0007614
name: short-term memory
namespace: biological_process
def: "The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
xref: Wikipedia:Short-term_memory
is_a: GO:0007613 ! memory

[Term]
id: GO:0007615
name: anesthesia-resistant memory
namespace: biological_process
def: "The memory process that results in the formation of consolidated memory resistant to disruption of the patterned activity of the brain, without requiring protein synthesis." [PMID:15143285, PMID:17088531]
is_a: GO:0007613 ! memory

[Term]
id: GO:0007616
name: long-term memory
namespace: biological_process
def: "The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
xref: Wikipedia:Long-term_memory
is_a: GO:0007613 ! memory

[Term]
id: GO:0007617
name: mating behavior
namespace: biological_process
def: "The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes." [GOC:ai, GOC:dph]
synonym: "mating behaviour" EXACT []
xref: Wikipedia:Mating_behaviour
is_a: GO:0044705 ! multi-organism reproductive behavior
intersection_of: GO:0007610 ! behavior
intersection_of: part_of GO:0007618 ! mating
relationship: part_of GO:0007618 ! mating

[Term]
id: GO:0007618
name: mating
namespace: biological_process
def: "The pairwise union of individuals for the purpose of sexual reproduction, ultimately resulting in the formation of zygotes." [GOC:jl, ISBN:0387520546]
is_a: GO:0044703 ! multi-organism reproductive process
relationship: part_of GO:0019953 ! sexual reproduction

[Term]
id: GO:0007619
name: courtship behavior
namespace: biological_process
def: "The behavioral interactions between organisms for the purpose of attracting sexual partners." [GOC:ai, GOC:dph]
synonym: "courtship behaviour" EXACT []
is_a: GO:0007617 ! mating behavior

[Term]
id: GO:0007620
name: copulation
namespace: biological_process
def: "The act of sexual union between male and female, involving the transfer of sperm." [ISBN:0721662544]
is_a: GO:0007618 ! mating

[Term]
id: GO:0007621
name: negative regulation of female receptivity
namespace: biological_process
def: "Any process that stops, prevents or reduces the receptiveness of a female to male advances." [GOC:bf, PMID:11092827]
synonym: "down regulation of female receptivity" EXACT []
synonym: "down-regulation of female receptivity" EXACT []
synonym: "downregulation of female receptivity" EXACT []
synonym: "inhibition of female receptivity" NARROW []
is_a: GO:0045924 ! regulation of female receptivity

[Term]
id: GO:0007622
name: rhythmic behavior
namespace: biological_process
def: "The specific behavior of an organism that recur with measured regularity." [GOC:jl, GOC:pr]
synonym: "rhythmic behavioral response to stimulus" EXACT []
synonym: "rhythmic behaviour" EXACT []
synonym: "rhythmic behavioural response to stimulus" EXACT []
is_a: GO:0007610 ! behavior
is_a: GO:0048511 ! rhythmic process

[Term]
id: GO:0007623
name: circadian rhythm
namespace: biological_process
alt_id: GO:0050895
def: "Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators]
subset: gosubset_prok
synonym: "circadian process" EXACT []
synonym: "circadian response" RELATED []
synonym: "response to circadian rhythm" RELATED []
xref: Wikipedia:Circadian_rhythm
is_a: GO:0048511 ! rhythmic process

[Term]
id: GO:0007624
name: ultradian rhythm
namespace: biological_process
def: "The specific actions or reactions of an organism that recur with a regularity more frequent than every 24 hours." [GOC:jl, PMID:19708721]
is_a: GO:0044699 ! single-organism process
is_a: GO:0048511 ! rhythmic process

[Term]
id: GO:0007625
name: grooming behavior
namespace: biological_process
def: "The specific behavior of an organism relating to grooming, cleaning and brushing to remove dirt and parasites." [GOC:jl, GOC:pr]
synonym: "grooming behaviour" EXACT []
is_a: GO:0044708 ! single-organism behavior

[Term]
id: GO:0007626
name: locomotory behavior
namespace: biological_process
def: "The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions." [GOC:dph]
subset: gosubset_prok
synonym: "behavior via locomotion" EXACT []
synonym: "locomotion in response to stimulus" EXACT []
synonym: "locomotory behavioral response to stimulus" EXACT []
synonym: "locomotory behaviour" EXACT []
synonym: "locomotory behavioural response to stimulus" EXACT []
is_a: GO:0007610 ! behavior

[Term]
id: GO:0007627
name: obsolete larval behavior (sensu Insecta)
namespace: biological_process
def: "OBSOLETE. Behavior in a larval form of an organism, an immature organism that must undergo metamorphosis to assume adult characteristics, as seen in insects." [GOC:ai, GOC:jid]
comment: This term was made obsolete because there is no clear difference between the sensu Insecta term and the generic term.
synonym: "larval behavior (sensu Insecta)" EXACT []
is_obsolete: true
replaced_by: GO:0030537

[Term]
id: GO:0007628
name: adult walking behavior
namespace: biological_process
def: "The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg." [GOC:jid, GOC:pr, ISBN:0198606907]
synonym: "adult walking behaviour" EXACT []
is_a: GO:0008344 ! adult locomotory behavior
is_a: GO:0090659 ! walking behavior

[Term]
id: GO:0007629
name: flight behavior
namespace: biological_process
def: "The response to external or internal stimuli that results in the locomotory process of flight. Flight is the self-propelled movement of an organism through the air." [GOC:jid, ISBN:0198606907]
synonym: "flight behaviour" EXACT []
is_a: GO:0008344 ! adult locomotory behavior

[Term]
id: GO:0007630
name: jump response
namespace: biological_process
def: "The sudden, usually upward, movement off the ground or other surface through sudden muscular effort in the legs, following exposure to an external stimulus." [GOC:jid, ISBN:0198606907]
is_a: GO:0008344 ! adult locomotory behavior

[Term]
id: GO:0007631
name: feeding behavior
namespace: biological_process
def: "Behavior associated with the intake of food." [GOC:mah]
comment: See also the biological process term 'behavior ; GO:0007610'.
synonym: "behavioral response to food" EXACT []
synonym: "behavioural response to food" EXACT []
synonym: "drinking" NARROW []
synonym: "eating" NARROW []
synonym: "feeding behaviour" EXACT []
xref: Wikipedia:List_of_feeding_behaviours
is_a: GO:0007610 ! behavior

[Term]
id: GO:0007632
name: visual behavior
namespace: biological_process
def: "The behavior of an organism in response to a visual stimulus." [GOC:jid, GOC:pr]
synonym: "behavioral response to visual stimulus" EXACT []
synonym: "behavioural response to visual stimulus" EXACT []
synonym: "visual behaviour" EXACT []
is_a: GO:0009416 ! response to light stimulus
is_a: GO:0044707 ! single-multicellular organism process
is_a: GO:0044708 ! single-organism behavior

[Term]
id: GO:0007633
name: pattern orientation
namespace: biological_process
def: "The actions or reactions of an individual in response to the orientation of a visual pattern. This is exemplified by some classes of insects which are able to detect and learn the orientation of a set of stripes and subsequently behaviorally discriminate between horizontal, vertical or 45 degree stripes." [GOC:jid, PMID:9933535]
synonym: "behavioral response to pattern orientation" EXACT []
synonym: "behavioural response to pattern orientation" EXACT []
is_a: GO:0007632 ! visual behavior

[Term]
id: GO:0007634
name: optokinetic behavior
namespace: biological_process
def: "The behavior of an organism pertaining to movement of the eyes and of objects in the visual field, as in nystagmus." [GOC:jid, GOC:pr, http://www.mercksource.com]
synonym: "optokinetic behaviour" EXACT []
is_a: GO:0007632 ! visual behavior

[Term]
id: GO:0007635
name: chemosensory behavior
namespace: biological_process
def: "Behavior that is dependent upon the sensation of chemicals." [GOC:go_curators]
synonym: "behavioral response to chemical stimulus" EXACT []
synonym: "behavioural response to chemical stimulus" EXACT []
synonym: "chemosensory behaviour" EXACT []
is_a: GO:0044708 ! single-organism behavior
relationship: part_of GO:0042221 ! response to chemical

[Term]
id: GO:0007636
name: chemosensory jump behavior
namespace: biological_process
def: "The sudden, usually upward, movement off the ground or other surface through sudden muscular effort in the legs, following exposure to a chemical substance." [GOC:jid]
synonym: "chemosensory jump behaviour" EXACT []
synonym: "jump response to chemical stimulus" EXACT []
is_a: GO:0007630 ! jump response
is_a: GO:0007635 ! chemosensory behavior

[Term]
id: GO:0007637
name: proboscis extension reflex
namespace: biological_process
def: "The extension, through direct muscle actions, of the proboscis (the trunk-like extension of the mouthparts on the adult external head) in response to a sugar stimulus." [FB:FBrf0044924, GOC:jid]
synonym: "behavioral response to sugar stimulus, proboscis extension" EXACT []
synonym: "proboscis extension in response to sugar stimulus" EXACT []
is_a: GO:0007635 ! chemosensory behavior
is_a: GO:0051780 ! behavioral response to nutrient
is_a: GO:0060004 ! reflex

[Term]
id: GO:0007638
name: mechanosensory behavior
namespace: biological_process
def: "Behavior that is dependent upon the sensation of a mechanical stimulus." [GOC:go_curators]
synonym: "behavioral response to mechanical stimulus" EXACT []
synonym: "behavioural response to mechanical stimulus" EXACT []
synonym: "mechanosensory behaviour" EXACT []
is_a: GO:0044708 ! single-organism behavior
relationship: part_of GO:0009612 ! response to mechanical stimulus

[Term]
id: GO:0007639
name: homeostasis of number of meristem cells
namespace: biological_process
def: "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in the meristem." [GOC:isa_complete]
is_a: GO:0010075 ! regulation of meristem growth
is_a: GO:0048873 ! homeostasis of number of cells within a tissue

[Term]
id: GO:0008001
name: obsolete fibrinogen
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it does not describe an activity.
synonym: "fibrinogen" EXACT []
is_obsolete: true
replaced_by: GO:0005577

[Term]
id: GO:0008002
name: lamina lucida
namespace: cellular_component
def: "The electron-lucent layer of the basal lamina adjacent to the basal plasma membrane of the cells that rest on the lamina." [ISBN:0815316194]
xref: Wikipedia:Lamina_lucida
is_a: GO:0044420 ! extracellular matrix component
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005605 ! basal lamina

[Term]
id: GO:0008003
name: lamina densa
namespace: cellular_component
def: "The electron-dense layer of the basal lamina; lies just below the lamina lucida." [ISBN:0815316194]
xref: Wikipedia:Lamina_densa
is_a: GO:0044420 ! extracellular matrix component
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005605 ! basal lamina

[Term]
id: GO:0008004
name: lamina reticularis
namespace: cellular_component
def: "A layer of the basal lamina that contains collagen fibrils and connects the basal lamina to the underlying connective tissue." [ISBN:0815316194]
is_a: GO:0044420 ! extracellular matrix component
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005605 ! basal lamina

[Term]
id: GO:0008008
name: obsolete membrane attack complex protein beta2 chain
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "membrane attack complex protein beta2 chain" EXACT []
is_obsolete: true
replaced_by: GO:0005579

[Term]
id: GO:0008009
name: chemokine activity
namespace: molecular_function
def: "The function of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria." [GOC:BHF, GOC:rl, http://en.wikipedia.org/wiki/Chemokine, http://www.copewithcytokines.de/cope.cgi?key=Cytokines, PMID:12183377]
comment: See also the molecular function term 'cytokine activity ; GO:0005125'.
subset: goslim_chembl
is_a: GO:0005125 ! cytokine activity
is_a: GO:0042379 ! chemokine receptor binding
relationship: part_of GO:0060326 ! cell chemotaxis

[Term]
id: GO:0008010
name: structural constituent of chitin-based larval cuticle
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
synonym: "structural constituent of larval cuticle" BROAD []
is_a: GO:0005214 ! structural constituent of chitin-based cuticle

[Term]
id: GO:0008011
name: structural constituent of pupal chitin-based cuticle
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a pupa. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
synonym: "structural constituent of pupal cuticle" BROAD []
is_a: GO:0005214 ! structural constituent of chitin-based cuticle

[Term]
id: GO:0008012
name: structural constituent of adult chitin-based cuticle
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of an adult organism. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
synonym: "structural constituent of adult cuticle" BROAD []
is_a: GO:0005214 ! structural constituent of chitin-based cuticle

[Term]
id: GO:0008013
name: beta-catenin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the beta subunit of the catenin complex." [GOC:bf]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0008014
name: obsolete calcium-dependent cell adhesion molecule activity
namespace: molecular_function
alt_id: GO:0001538
def: "OBSOLETE. A calcium-dependent cell adhesion protein (type I membrane protein) that interacts in a homophilic manner in cell-cell interactions." [ISBN:0198506732]
comment: This term was made obsolete because it represents a gene product.
synonym: "cadherin" NARROW []
synonym: "calcium-dependent cell adhesion molecule activity" EXACT []
is_obsolete: true
consider: GO:0005515
consider: GO:0016021
consider: GO:0016339

[Term]
id: GO:0008015
name: blood circulation
namespace: biological_process
alt_id: GO:0070261
def: "The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products." [GOC:mtg_heart, ISBN:0192800825]
subset: goslim_pir
synonym: "hemolymph circulation" RELATED []
is_a: GO:0003013 ! circulatory system process

[Term]
id: GO:0008016
name: regulation of heart contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "regulation of cardiac contraction" EXACT []
is_a: GO:1903522 ! regulation of blood circulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060047 ! heart contraction
relationship: regulates GO:0060047 ! heart contraction

[Term]
id: GO:0008017
name: microtubule binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc]
synonym: "microtubule severing activity" RELATED []
synonym: "microtubule/chromatin interaction" RELATED []
is_a: GO:0015631 ! tubulin binding
is_a: GO:0032403 ! protein complex binding

[Term]
id: GO:0008018
name: obsolete structural protein of chorion (sensu Drosophila)
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because the function is covered by a parent term.
synonym: "structural protein of chorion (sensu Drosophila)" EXACT []
is_obsolete: true
replaced_by: GO:0005213

[Term]
id: GO:0008019
name: obsolete macrophage receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because its name is ambiguous, and it was never defined.
synonym: "macrophage receptor activity" EXACT []
is_obsolete: true
consider: GO:0005044
consider: GO:0008329

[Term]
id: GO:0008020
name: G-protein coupled photoreceptor activity
namespace: molecular_function
alt_id: GO:0004975
def: "Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph, ISBN:0198506732]
subset: gosubset_prok
synonym: "G protein coupled photoreceptor activity" EXACT []
synonym: "G-protein-coupled photoreceptor activity" EXACT []
synonym: "photoreceptor activity, G-protein coupled" EXACT [GOC:bf]
is_a: GO:0004930 ! G-protein coupled receptor activity
is_a: GO:0009881 ! photoreceptor activity
relationship: part_of GO:0009584 ! detection of visible light

[Term]
id: GO:0008021
name: synaptic vesicle
namespace: cellular_component
def: "A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709, PMID:12563290]
comment: This term should not be confused with GO:0097547 'synaptic vesicle protein transport vesicle'. STVs and synaptic vesicles differ both functionally and morphologically. Functionally, STVs are transport vesicles that deliver synaptic vesicle proteins to synapses, while synaptic vesicles are responsible for transmitter release at synapses. Morphologically, synaptic vesicles are very homogeneous, while STVs are very heterogeneous in size and shape. STVs might be a precursor for synaptic vesicles.
subset: goslim_synapse
synonym: "docked vesicle" NARROW [NIF_Subcellular:sao403156667]
xref: NIF_Subcellular:sao1071221672
xref: Wikipedia:Synaptic_vesicle
is_a: GO:0044456 ! synapse part
is_a: GO:0070382 ! exocytic vesicle
is_a: GO:0097458 ! neuron part
relationship: part_of GO:0098793 ! presynapse

[Term]
id: GO:0008022
name: protein C-terminus binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxy function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue." [ISBN:0198506732]
subset: goslim_chembl
synonym: "C-terminal binding" EXACT []
synonym: "C-terminal end binding" EXACT [GOC:sl]
synonym: "carboxy-terminal binding" RELATED [GOC:jsg]
synonym: "carboxy-terminus binding" RELATED [GOC:sl]
synonym: "carboxyl-terminal binding" RELATED [GOC:jsg]
synonym: "carboxyl-terminus binding" RELATED [GOC:sl]
synonym: "carboxylate-terminal binding" RELATED [GOC:jsg]
synonym: "carboxylate-terminus binding" NARROW [GOC:jsg]
synonym: "COOH-terminal binding" NARROW [GOC:jsg]
synonym: "COOH-terminus binding" NARROW [GOC:jsg, GOC:sl]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0008023
name: transcription elongation factor complex
namespace: cellular_component
def: "Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation." [GOC:jl]
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part

[Term]
id: GO:0008024
name: cyclin/CDK positive transcription elongation factor complex
namespace: cellular_component
def: "A transcription elongation factor complex that facilitates the transition from abortive to productive elongation by phosphorylating the CTD domain of the large subunit of DNA-directed RNA polymerase II, holoenzyme. Contains a cyclin and a cyclin-dependent protein kinase catalytic subunit." [GOC:bhm, GOC:vw, PMID:10766736, PMID:16721054, PMID:17079683, PMID:19328067, PMID:7759473]
comment: See also the cellular component terms 'cyclin-dependent protein kinase activating kinase holoenzyme complex ; GO:0019907' and 'DNA-directed RNA polymerase II, holoenzyme ; GO:0016591'.
synonym: "positive transcription elongation factor complex b" RELATED []
is_a: GO:0008023 ! transcription elongation factor complex
is_a: GO:0019908 ! nuclear cyclin-dependent protein kinase holoenzyme complex
is_a: GO:0032806 ! carboxy-terminal domain protein kinase complex

[Term]
id: GO:0008025
name: obsolete diazepam binding inhibitor activity
namespace: molecular_function
def: "OBSOLETE. The diazepam binding inhibitor is a 10kDa 86-residue polypeptide that acts as an endogenous ligand for a mitochondrial receptor (formerly regarded as a peripheral benzodiazepine binding site) in steroidogenic cells and regulates stimulation of steroidogenesis by tropic hormones. It also binds to the GABA-A receptor and modulates glucose-dependent insulin secretion and synthesis of acyl-CoA esters." [ISBN:0198506732, PMID:11883709]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "DBI" EXACT []
synonym: "diazepam binding inhibitor activity" EXACT []
synonym: "diazepam-binding inhibitor activity" EXACT []
is_obsolete: true
consider: GO:0004857
consider: GO:0030156
consider: GO:0050796
consider: GO:0050809
consider: GO:0050810
consider: GO:0050811
consider: GO:0050812

[Term]
id: GO:0008026
name: ATP-dependent helicase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]
subset: gosubset_prok
is_a: GO:0042623 ! ATPase activity, coupled
is_a: GO:0070035 ! purine NTP-dependent helicase activity

[Term]
id: GO:0008028
name: monocarboxylic acid transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0008505
def: "Enables the transfer of monocarboxylic acids from one side of the membrane to the other. A monocarboxylic acid is an organic acid with one COOH group." [GOC:ai]
subset: gosubset_prok
synonym: "monocarboxylate carrier" NARROW []
synonym: "prostaglandin/thromboxane transporter activity" NARROW []
xref: Reactome:REACT_109885 "MCTs mediate proton-coupled transport of monocarboxylates and ketone bodies, Rattus norvegicus"
xref: Reactome:REACT_114096 "MCTs mediate proton-coupled transport of monocarboxylates and ketone bodies, Drosophila melanogaster"
xref: Reactome:REACT_115467 "MCTs mediate proton-coupled transport of monocarboxylates and ketone bodies, Saccharomyces cerevisiae"
xref: Reactome:REACT_118070 "Na+-dependent monocarboxylate transport by SMCT, Xenopus tropicalis"
xref: Reactome:REACT_118165 "Na+-dependent monocarboxylate transport by SMCT, Gallus gallus"
xref: Reactome:REACT_118306 "Na+-dependent monocarboxylate transport by SMCT, Mus musculus"
xref: Reactome:REACT_118319 "Na+-dependent monocarboxylate transport by SMCT, Staphylococcus aureus N315"
xref: Reactome:REACT_118338 "Na+-dependent monocarboxylate transport by SMCT, Bos taurus"
xref: Reactome:REACT_118385 "Na+-dependent monocarboxylate transport by SMCT, Sus scrofa"
xref: Reactome:REACT_118391 "Na+-dependent monocarboxylate transport by SMCT, Danio rerio"
xref: Reactome:REACT_118408 "Na+-dependent monocarboxylate transport by SMCT, Rattus norvegicus"
xref: Reactome:REACT_118453 "Na+-dependent monocarboxylate transport by SMCT, Canis familiaris"
xref: Reactome:REACT_118475 "Na+-dependent monocarboxylate transport by SMCT, Taeniopygia guttata"
xref: Reactome:REACT_19245 "Na+-dependent monocarboxylate transport by SMCT, Homo sapiens"
xref: Reactome:REACT_20553 "MCTs mediate proton-coupled transport of monocarboxylates and ketone bodies, Homo sapiens"
xref: Reactome:REACT_31190 "MCTs mediate proton-coupled transport of monocarboxylates and ketone bodies, Mus musculus"
xref: Reactome:REACT_32694 "MCTs mediate proton-coupled transport of monocarboxylates and ketone bodies, Canis familiaris"
xref: Reactome:REACT_80948 "MCTs mediate proton-coupled transport of monocarboxylates and ketone bodies, Gallus gallus"
xref: Reactome:REACT_81048 "MCTs mediate proton-coupled transport of monocarboxylates and ketone bodies, Sus scrofa"
xref: Reactome:REACT_81713 "MCTs mediate proton-coupled transport of monocarboxylates and ketone bodies, Xenopus tropicalis"
xref: Reactome:REACT_83651 "MCTs mediate proton-coupled transport of monocarboxylates and ketone bodies, Bos taurus"
xref: Reactome:REACT_86798 "MCTs mediate proton-coupled transport of monocarboxylates and ketone bodies, Taeniopygia guttata"
xref: Reactome:REACT_96032 "MCTs mediate proton-coupled transport of monocarboxylates and ketone bodies, Danio rerio"
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity
relationship: part_of GO:0015718 ! monocarboxylic acid transport

[Term]
id: GO:0008029
name: pentraxin receptor activity
namespace: molecular_function
def: "Combining with a pentraxin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]
comment: Note that pentraxins include such proteins as serum amyloid P component (SAP) and C-reactive protein (CRP).
synonym: "pentaxin receptor" EXACT []
is_a: GO:0001847 ! opsonin receptor activity
relationship: has_part GO:0001864 ! pentraxin binding

[Term]
id: GO:0008030
name: neuronal pentraxin receptor activity
namespace: molecular_function
def: "Combining with a neuronal pentraxin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling, PMID:18840757]
synonym: "neuronal pentaxin receptor" EXACT []
is_a: GO:0008029 ! pentraxin receptor activity

[Term]
id: GO:0008031
name: eclosion hormone activity
namespace: molecular_function
def: "The action characteristic of eclosion hormone, a peptide hormone that, upon receptor binding, triggers the death of certain muscles and neurons during insect metamorphosis." [GOC:mah, ISBN:0198506732]
is_a: GO:0005184 ! neuropeptide hormone activity

[Term]
id: GO:0008033
name: tRNA processing
namespace: biological_process
def: "The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]
subset: goslim_yeast
subset: gosubset_prok
synonym: "tRNA maturation" EXACT [GOC:vw]
is_a: GO:0006399 ! tRNA metabolic process
is_a: GO:0034470 ! ncRNA processing

[Term]
id: GO:0008034
name: obsolete lipoprotein binding
namespace: molecular_function
def: "OBSOLETE. Interacting selectively and non-covalently with any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids." [GOC:jl, ISBN:0198506732]
comment: This term was made obsolete because its text definition and implicit ontology-structure definition disagreed, and as a result the term had been used in annotations with more than one meaning.
synonym: "lipoprotein binding" EXACT []
is_obsolete: true
consider: GO:0071723
consider: GO:0071813

[Term]
id: GO:0008035
name: high-density lipoprotein particle binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with high-density lipoprotein particle, a lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE." [GOC:mah]
synonym: "HDL binding" EXACT [GOC:mah]
is_a: GO:0071813 ! lipoprotein particle binding

[Term]
id: GO:0008036
name: diuretic hormone receptor activity
namespace: molecular_function
def: "Combining with a diuretic hormone and transmitting the signal to initiate a change in cell activity." [GOC:ai, GOC:signaling]
is_a: GO:0038023 ! signaling receptor activity
relationship: part_of GO:0009755 ! hormone-mediated signaling pathway

[Term]
id: GO:0008037
name: cell recognition
namespace: biological_process
def: "The process in which a cell in an organism interprets its surroundings." [GOC:go_curators]
subset: goslim_pir
synonym: "recognition of surroundings by cell" EXACT [GOC:curators]
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0008038
name: neuron recognition
namespace: biological_process
def: "The process in which a neuronal cell in a multicellular organism interprets its surroundings." [GOC:go_curators]
synonym: "neuronal cell recognition" EXACT []
is_a: GO:0008037 ! cell recognition
relationship: part_of GO:0048666 ! neuron development

[Term]
id: GO:0008039
name: synaptic target recognition
namespace: biological_process
def: "The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437]
subset: goslim_synapse
synonym: "neuronal targeting" EXACT []
is_a: GO:0008038 ! neuron recognition

[Term]
id: GO:0008041
name: obsolete storage protein of fat body (sensu Insecta)
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it describes a cellular location rather than a function.
synonym: "storage protein of fat body (sensu Insecta)" EXACT []
is_obsolete: true
replaced_by: GO:0045735

[Term]
id: GO:0008042
name: obsolete iron-sulfur electron transfer carrier
namespace: molecular_function
def: "OBSOLETE. An iron-sulfur protein that serves as an electron acceptor and electron donor in an electron transport system." [GOC:kd]
comment: This term was made obsolete because it refers to a class of gene products.
synonym: "ferredoxin" NARROW []
synonym: "iron-sulfur electron transfer carrier" EXACT []
synonym: "iron-sulphur electron transfer carrier" EXACT []
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0008043
name: intracellular ferritin complex
namespace: cellular_component
def: "A ferritin complex located in the cell. Intracellular ferritin complexes contain 24 subunits, in a mixture of L (light) chains and H (heavy) chains." [GOC:jl, GOC:mah, PMID:19154717]
is_a: GO:0044424 ! intracellular part
is_a: GO:0070288 ! ferritin complex

[Term]
id: GO:0008044
name: obsolete adult behavior (sensu Insecta)
namespace: biological_process
def: "OBSOLETE. Behavior in a fully developed and mature organism, as seen in insects." [GOC:bf, GOC:jid]
comment: This term was made obsolete because there is no clear difference between the sensu Insecta term and the generic term.
synonym: "adult behavior (sensu Insecta)" EXACT []
is_obsolete: true
replaced_by: GO:0030534

[Term]
id: GO:0008045
name: motor neuron axon guidance
namespace: biological_process
def: "The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]
synonym: "motoneuron axon guidance" EXACT []
synonym: "motor axon guidance" EXACT []
synonym: "motor axon pathfinding" EXACT [GOC:mah]
is_a: GO:0007411 ! axon guidance

[Term]
id: GO:0008046
name: axon guidance receptor activity
namespace: molecular_function
def: "Combining with an extracellular messenger and transmitting the signal from one side of the membrane to the other to results in a change in cellular activity involved in axon guidance." [GOC:dph, GOC:signaling, GOC:tb, PMID:15107857, PMID:15339666]
synonym: "receptor activity involved in axon guidance" EXACT [GOC:bf, GOC:signaling]
is_a: GO:0004888 ! transmembrane signaling receptor activity
intersection_of: GO:0004888 ! transmembrane signaling receptor activity
intersection_of: part_of GO:0007411 ! axon guidance
relationship: part_of GO:0007411 ! axon guidance

[Term]
id: GO:0008047
name: enzyme activator activity
namespace: molecular_function
alt_id: GO:0010577
def: "Binds to and increases the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]
subset: gosubset_prok
synonym: "metalloenzyme activator activity" NARROW []
is_a: GO:0030234 ! enzyme regulator activity
relationship: part_of GO:0043085 ! positive regulation of catalytic activity

[Term]
id: GO:0008048
name: calcium sensitive guanylate cyclase activator activity
namespace: molecular_function
def: "Binds to and increases the activity of guanylate cyclase in response to a change in calcium ion concentration." [GOC:mah]
is_a: GO:0030250 ! guanylate cyclase activator activity

[Term]
id: GO:0008049
name: male courtship behavior
namespace: biological_process
alt_id: GO:0016542
def: "The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, GOC:pr]
synonym: "male courtship behaviour" EXACT []
is_a: GO:0060179 ! male mating behavior
relationship: part_of GO:0007619 ! courtship behavior

[Term]
id: GO:0008050
name: female courtship behavior
namespace: biological_process
def: "The behavior of a female, for the purpose of attracting a sexual partner." [GOC:bf, GOC:pr]
synonym: "female courtship behaviour" EXACT []
is_a: GO:0060180 ! female mating behavior
relationship: part_of GO:0007619 ! courtship behavior

[Term]
id: GO:0008051
name: obsolete farnesyl-diphosphate farnesyl transferase complex
namespace: cellular_component
def: "OBSOLETE. A complex that possesses farnesyl-diphosphate farnesyl transferase activity." [GOC:mah]
comment: This term was made obsolete because there is no evidence that this enzyme ever exists as anything other than a monomer.
synonym: "farnesyl-diphosphate farnesyl transferase complex" EXACT []
is_obsolete: true
consider: GO:0004310

[Term]
id: GO:0008052
name: sensory organ boundary specification
namespace: biological_process
def: "The process in which boundaries between a sensory organ and the surrounding tissue are established and maintained." [GO_REF:0000021, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "sense organ boundary specification" EXACT [GOC:dph]
is_a: GO:0010160 ! formation of organ boundary
relationship: part_of GO:0007423 ! sensory organ development

[Term]
id: GO:0008053
name: mitochondrial fusion
namespace: biological_process
def: "Merging of two or more mitochondria within a cell to form a single compartment." [PMID:11038192]
is_a: GO:0007005 ! mitochondrion organization
is_a: GO:0044801 ! single-organism membrane fusion
is_a: GO:0048284 ! organelle fusion
is_a: GO:1902589 ! single-organism organelle organization

[Term]
id: GO:0008054
name: negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cyclins, proteins whose levels in a cell varies markedly during the cell cycle, and which play key roles in regulating cell cycle phase transitions via the negative regulation of a cyclin-dependent kinase." [GOC:mah, PMID:15840442]
synonym: "cyclin breakdown" EXACT []
synonym: "cyclin catabolic process" EXACT []
synonym: "cyclin catabolism" EXACT []
synonym: "cyclin degradation" EXACT []
synonym: "degradation of cyclin" EXACT []
is_a: GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process
relationship: part_of GO:0045736 ! negative regulation of cyclin-dependent protein serine/threonine kinase activity

[Term]
id: GO:0008055
name: ocellus pigment biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ocellus pigments, any general or particular coloring matter in living organisms, found or utilized in the ocellus, a minute simple eye found in many invertebrates." [GOC:ai, PMID:15176085, PMID:18421706]
synonym: "ocellus pigment anabolism" EXACT []
synonym: "ocellus pigment biosynthesis" EXACT []
synonym: "ocellus pigment formation" EXACT []
synonym: "ocellus pigment synthesis" EXACT []
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:0046148 ! pigment biosynthetic process
is_a: GO:0046158 ! ocellus pigment metabolic process

[Term]
id: GO:0008056
name: ocellus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the ocellus over time, from its formation to the mature structure. The ocellus is a simple visual organ of insects." [http://fly.ebi.ac.uk/.bin/cvreport2?id=FBcv0004540]
is_a: GO:0007423 ! sensory organ development
relationship: part_of GO:0035214 ! eye-antennal disc development

[Term]
id: GO:0008057
name: eye pigment granule organization
namespace: biological_process
alt_id: GO:0008059
alt_id: GO:0045318
alt_id: GO:0048751
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of intracellular pigment storage granules in the eye." [PMID:9303295]
synonym: "eye pigment granule organisation" EXACT [GOC:mah]
synonym: "eye pigment granule organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0048753 ! pigment granule organization

[Term]
id: GO:0008058
name: ocellus pigment granule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of intracellular pigment storage granules in the ocellus." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm]
synonym: "ocellus pigment granule organisation" EXACT [GOC:curators]
synonym: "ocellus pigment granule organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0048753 ! pigment granule organization

[Term]
id: GO:0008061
name: chitin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0097367 ! carbohydrate derivative binding

[Term]
id: GO:0008062
name: eclosion rhythm
namespace: biological_process
def: "The timing of the emergence of the adult fly from its pupal case, which usually occurs at dawn." [PMID:11715043]
is_a: GO:0044708 ! single-organism behavior
is_a: GO:0048512 ! circadian behavior
relationship: part_of GO:0007562 ! eclosion

[Term]
id: GO:0008063
name: Toll signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:11135568, PMID:19126860]
synonym: "Tl signaling pathway" EXACT []
synonym: "Tl signalling pathway" EXACT []
synonym: "Toll signalling pathway" EXACT []
xref: Reactome:REACT_105500 "Toll Like Receptor 4 (TLR4) Cascade, Schizosaccharomyces pombe"
xref: Reactome:REACT_109159 "Toll Like Receptor 4 (TLR4) Cascade, Rattus norvegicus"
xref: Reactome:REACT_109528 "Toll Like Receptor 4 (TLR4) Cascade, Caenorhabditis elegans"
xref: Reactome:REACT_109590 "Toll Like Receptor 4 (TLR4) Cascade, Sus scrofa"
xref: Reactome:REACT_109895 "Toll Like Receptor 4 (TLR4) Cascade, Drosophila melanogaster"
xref: Reactome:REACT_29964 "Toll Like Receptor 4 (TLR4) Cascade, Canis familiaris"
xref: Reactome:REACT_33924 "Toll Like Receptor 4 (TLR4) Cascade, Taeniopygia guttata"
xref: Reactome:REACT_6894 "Toll Like Receptor 4 (TLR4) Cascade, Homo sapiens"
xref: Reactome:REACT_77076 "Toll Like Receptor 4 (TLR4) Cascade, Xenopus tropicalis"
xref: Reactome:REACT_80044 "Toll Like Receptor 4 (TLR4) Cascade, Arabidopsis thaliana"
xref: Reactome:REACT_80184 "Toll Like Receptor 4 (TLR4) Cascade, Bos taurus"
xref: Reactome:REACT_84215 "Toll Like Receptor 4 (TLR4) Cascade, Dictyostelium discoideum"
xref: Reactome:REACT_84510 "Toll Like Receptor 4 (TLR4) Cascade, Saccharomyces cerevisiae"
xref: Reactome:REACT_88848 "Toll Like Receptor 4 (TLR4) Cascade, Mus musculus"
xref: Reactome:REACT_91584 "Toll Like Receptor 4 (TLR4) Cascade, Oryza sativa"
xref: Reactome:REACT_92536 "Toll Like Receptor 4 (TLR4) Cascade, Gallus gallus"
xref: Reactome:REACT_93608 "Toll Like Receptor 4 (TLR4) Cascade, Danio rerio"
is_a: GO:0007166 ! cell surface receptor signaling pathway

[Term]
id: GO:0008064
name: regulation of actin polymerization or depolymerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament." [GOC:mah]
is_a: GO:0030832 ! regulation of actin filament length
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008154 ! actin polymerization or depolymerization
relationship: regulates GO:0008154 ! actin polymerization or depolymerization

[Term]
id: GO:0008065
name: establishment of blood-nerve barrier
namespace: biological_process
def: "The establishment of the barrier between the perineurium of peripheral nerves and the vascular endothelium of endoneurial capillaries. The perineurium acts as a diffusion barrier, but ion permeability at the blood-nerve barrier is still higher than at the blood-brain barrier." [GOC:dgh]
synonym: "establishment of blood/nerve barrier" EXACT []
is_a: GO:0001885 ! endothelial cell development
relationship: part_of GO:0007422 ! peripheral nervous system development

[Term]
id: GO:0008066
name: glutamate receptor activity
namespace: molecular_function
def: "Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:ai, GOC:signaling]
subset: gosubset_prok
is_a: GO:0004888 ! transmembrane signaling receptor activity
relationship: has_part GO:0016595 ! glutamate binding

[Term]
id: GO:0008067
name: obsolete metabotropic glutamate, GABA-B-like receptor activity
namespace: molecular_function
alt_id: GO:0001643
alt_id: GO:0001645
def: "OBSOLETE. A G-protein coupled receptor that is structurally/functionally related to the metabotropic glutamate receptor." [GOC:dph, GOC:mah, GOC:tb, IUPHAR_GPCR:1285]
comment: This term was made obsolete because it represents a gene product and is named based on protein features.
synonym: "class C G protein coupled receptor" BROAD []
synonym: "class C G-protein coupled receptor" BROAD []
synonym: "class C GPCR" BROAD []
synonym: "class C orphan receptor activity" EXACT []
synonym: "metabotropic glutamate, GABA-B-like receptor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0008068
name: extracellular-glutamate-gated chloride channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a chloride ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'glutamate receptor activity ; GO:0008066'.
is_a: GO:0005234 ! extracellular-glutamate-gated ion channel activity
is_a: GO:0005254 ! chloride channel activity

[Term]
id: GO:0008069
name: dorsal/ventral axis specification, ovarian follicular epithelium
namespace: biological_process
def: "Polarization of the ovarian follicle cells along the dorsal/ventral axis. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:dph, GOC:mtg_sensu, GOC:tb]
synonym: "dorsal-ventral axis specification, ovarian follicular epithelium" EXACT [GOC:mah]
synonym: "dorsal/ventral axis determination, follicular epithelium" RELATED []
synonym: "dorsal/ventral axis determination, ovarian follicular epithelium" EXACT [GOC:dph, GOC:tb]
synonym: "dorsoventral axis specification, ovarian follicular epithelium" EXACT [GOC:mah]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0009950 ! dorsal/ventral axis specification
is_a: GO:0016334 ! establishment or maintenance of polarity of follicular epithelium
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
relationship: part_of GO:0030707 ! ovarian follicle cell development

[Term]
id: GO:0008070
name: maternal determination of dorsal/ventral axis, ovarian follicular epithelium, germ-line encoded
namespace: biological_process
def: "Polarization of the ovarian follicle cells along the dorsal-ventral axis by a gene product encoded by cells of the germ line." [GOC:mtg_sensu, ISBN:0879694238]
synonym: "maternal determination of dorsal-ventral axis, ovarian follicular epithelium, germ-line encoded" EXACT [GOC:mah]
synonym: "maternal determination of dorsoventral axis, ovarian follicular epithelium, germ-line encoded" EXACT [GOC:mah]
is_a: GO:0008069 ! dorsal/ventral axis specification, ovarian follicular epithelium

[Term]
id: GO:0008071
name: maternal determination of dorsal/ventral axis, ovarian follicular epithelium, soma encoded
namespace: biological_process
def: "Polarization of the ovarian follicle cells along the dorsal-ventral axis by a gene product encoded by somatic cells. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
synonym: "maternal determination of dorsal-ventral axis, ovarian follicular epithelium, soma encoded" EXACT [GOC:mah]
synonym: "maternal determination of dorsal/ventral axis, follicular epithelium, soma encoded" BROAD []
synonym: "maternal determination of dorsoventral axis, ovarian follicular epithelium, soma encoded" EXACT [GOC:mah]
is_a: GO:0008069 ! dorsal/ventral axis specification, ovarian follicular epithelium

[Term]
id: GO:0008073
name: ornithine decarboxylase inhibitor activity
namespace: molecular_function
def: "The stopping, prevention or reduction of the activity of the enzyme ornithine decarboxylase." [GOC:jl]
is_a: GO:0004857 ! enzyme inhibitor activity
is_a: GO:0042979 ! ornithine decarboxylase regulator activity
relationship: negatively_regulates GO:0004586 ! ornithine decarboxylase activity

[Term]
id: GO:0008074
name: guanylate cyclase complex, soluble
namespace: cellular_component
def: "Complex that possesses guanylate cyclase activity and is not bound to a membrane." [GOC:mah]
comment: See also the molecular function term 'guanylate cyclase activity ; GO:0004383'.
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0008075
name: obsolete receptor guanylate cyclase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2]
comment: This term was made obsolete because it represents a class of gene products.
synonym: "receptor guanylate cyclase activity" EXACT []
is_obsolete: true
consider: GO:0004383
consider: GO:0004872

[Term]
id: GO:0008076
name: voltage-gated potassium channel complex
namespace: cellular_component
def: "A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]
subset: gosubset_prok
synonym: "voltage gated potassium channel complex" EXACT []
synonym: "voltage-dependent potassium channel complex" EXACT []
synonym: "voltage-sensitive potassium channel complex" EXACT []
xref: NIF_Subcellular:sao371494298
is_a: GO:0034705 ! potassium channel complex
is_a: GO:0098797 ! plasma membrane protein complex
relationship: part_of GO:0005887 ! integral component of plasma membrane

[Term]
id: GO:0008077
name: obsolete Hsp70/Hsp90 organizing protein activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:rb]
comment: This term was made obsolete because it represents a specific gene product rather than a molecular function.
synonym: "Hsp70/Hsp90 organising protein activity" EXACT []
synonym: "Hsp70/Hsp90 organizing protein activity" EXACT []
is_obsolete: true
consider: GO:0030674

[Term]
id: GO:0008078
name: mesodermal cell migration
namespace: biological_process
def: "The orderly movement of mesodermal cells from one site to another." [GOC:ascb_2009, GOC:dph, GOC:mah, GOC:sat, GOC:tb, PMID:25119047]
synonym: "mesoderm cell migration" EXACT []
is_a: GO:0001667 ! ameboidal-type cell migration

[Term]
id: GO:0008079
name: translation termination factor activity
namespace: molecular_function
def: "Functions in the termination of translation." [GOC:ma]
subset: gosubset_prok
is_a: GO:0008135 ! translation factor activity, RNA binding
relationship: part_of GO:0006415 ! translational termination

[Term]
id: GO:0008080
name: N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]
subset: gosubset_prok
xref: EC:2.3.1.-
is_a: GO:0016407 ! acetyltransferase activity
is_a: GO:0016410 ! N-acyltransferase activity

[Term]
id: GO:0008081
name: phosphoric diester hydrolase activity
namespace: molecular_function
alt_id: GO:0004434
alt_id: GO:0016792
def: "Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4, GOC:curators]
subset: goslim_chembl
subset: gosubset_prok
synonym: "endonuclease VIII activity" RELATED []
synonym: "inositol or phosphatidylinositol phosphodiesterase activity" NARROW []
synonym: "inositol/phosphatidylinositol phosphodiesterase activity" NARROW []
synonym: "phosphodiesterase" NARROW []
xref: EC:3.1.4
is_a: GO:0042578 ! phosphoric ester hydrolase activity

[Term]
id: GO:0008083
name: growth factor activity
namespace: molecular_function
def: "The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]
subset: goslim_chembl
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0008084
name: imaginal disc growth factor receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an imaginal disc growth factor receptor." [GOC:mah]
synonym: "imaginal disc growth factor" NARROW []
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0008085
name: obsolete phototransduction, visible light, light adaptation
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because the term name is ambiguous.
synonym: "phototransduction, visible light, light adaptation" EXACT []
is_obsolete: true
consider: GO:0007602

[Term]
id: GO:0008086
name: light-activated voltage-gated calcium channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a calcium ion by a voltage-gated channel that is activated in response to light. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport]
synonym: "light-activated voltage gated calcium channel activity" EXACT []
synonym: "light-activated voltage-dependent calcium channel activity" EXACT []
is_a: GO:0004871 ! signal transducer activity
is_a: GO:0005245 ! voltage-gated calcium channel activity
is_a: GO:0010461 ! light-activated ion channel activity
relationship: part_of GO:0019722 ! calcium-mediated signaling

[Term]
id: GO:0008087
name: light-activated voltage-gated calcium channel complex
namespace: cellular_component
def: "A protein complex that forms a transmembrane channel through which calcium ions may cross a cell membrane in response to changes in membrane potential generated in response to a light stimulus." [GOC:mah, PMID:9223679]
synonym: "light-activated voltage gated calcium channel complex" EXACT []
synonym: "light-activated voltage-dependent calcium channel complex" EXACT []
synonym: "light-activated voltage-sensitive calcium channel complex" EXACT []
is_a: GO:0005891 ! voltage-gated calcium channel complex

[Term]
id: GO:0008088
name: axo-dendritic transport
namespace: biological_process
def: "The directed movement of organelles or molecules along microtubules in neuron projections." [ISBN:0815316194]
subset: goslim_synapse
synonym: "axon cargo transport" NARROW []
synonym: "axonal transport" NARROW []
xref: Wikipedia:Axoplasmic_transport
is_a: GO:0010970 ! establishment of localization by movement along microtubule
is_a: GO:0030705 ! cytoskeleton-dependent intracellular transport
relationship: occurs_in GO:0043005 ! neuron projection

[Term]
id: GO:0008089
name: anterograde axonal transport
namespace: biological_process
def: "The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons." [ISBN:0815316194]
subset: goslim_synapse
synonym: "anterograde axon cargo transport" EXACT []
is_a: GO:0008088 ! axo-dendritic transport
relationship: occurs_in GO:1904115 ! axon cytoplasm

[Term]
id: GO:0008090
name: retrograde axonal transport
namespace: biological_process
def: "The directed movement of organelles or molecules along microtubules from the cell periphery toward the cell body in nerve cell axons." [ISBN:0815316194]
subset: goslim_synapse
synonym: "retrograde axon cargo transport" EXACT []
is_a: GO:0008088 ! axo-dendritic transport
relationship: occurs_in GO:1904115 ! axon cytoplasm

[Term]
id: GO:0008091
name: spectrin
namespace: cellular_component
def: "Membrane associated dimeric protein (240 and 220 kDa) of erythrocytes. Forms a complex with ankyrin, actin and probably other components of the membrane cytoskeleton, so that there is a mesh of proteins underlying the plasma membrane, potentially restricting the lateral mobility of integral proteins." [GOC:curators, ISBN:0815316194]
xref: NIF_Subcellular:sao536287099
xref: Wikipedia:Spectrin
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044448 ! cell cortex part
relationship: part_of GO:0030864 ! cortical actin cytoskeleton

[Term]
id: GO:0008092
name: cytoskeletal protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_yeast
subset: gosubset_prok
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0008093
name: cytoskeletal adaptor activity
namespace: molecular_function
def: "The binding activity of a molecule that brings together a cytoskeletal protein and one or more other molecules, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07]
is_a: GO:0008092 ! cytoskeletal protein binding
is_a: GO:0030674 ! protein binding, bridging

[Term]
id: GO:0008094
name: DNA-dependent ATPase activity
namespace: molecular_function
alt_id: GO:0004011
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single- or double-stranded DNA, and it drives another reaction." [EC:3.6.1.3, GOC:jl]
subset: gosubset_prok
synonym: "adenosinetriphosphatase (DNA-dependent)" EXACT []
synonym: "DNA dependent ATPase activity" EXACT []
synonym: "DNA-dependent adenosinetriphosphatase activity" EXACT []
is_a: GO:0042623 ! ATPase activity, coupled

[Term]
id: GO:0008096
name: juvenile hormone epoxide hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the epoxide in a juvenile hormone to the corresponding diol." [GOC:mah, PMID:8396141]
xref: EC:3.3.2.-
is_a: GO:0004301 ! epoxide hydrolase activity

[Term]
id: GO:0008097
name: 5S rRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with 5S ribosomal RNA, the smallest RNA constituent of a ribosome." [GOC:jl, ISBN:0321000382]
subset: gosubset_prok
is_a: GO:0019843 ! rRNA binding

[Term]
id: GO:0008098
name: 5S rRNA primary transcript binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the unprocessed 5S ribosomal RNA transcript." [GOC:jl]
is_a: GO:0008097 ! 5S rRNA binding

[Term]
id: GO:0008100
name: obsolete lipophorin
namespace: molecular_function
def: "OBSOLETE. Any member of the major class of lipid-transporting proteins found in the hemolymph of insects." [ISBN:0198506732]
comment: This term was made obsolete because it represents a class of gene products.
synonym: "lipophorin" EXACT []
is_obsolete: true
replaced_by: GO:0005319

[Term]
id: GO:0008101
name: decapentaplegic signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of decapentaplegic (dpp) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:sart, PMID:17428827]
synonym: "decapentaplegic receptor signaling pathway" RELATED [GOC:bf, GOC:sart, GOC:signaling]
synonym: "decapentaplegic receptor signalling pathway" RELATED []
synonym: "dpp receptor signaling pathway" RELATED []
synonym: "dpp receptor signalling pathway" RELATED []
synonym: "dpp signaling pathway" RELATED [GOC:bf]
is_a: GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway

[Term]
id: GO:0008103
name: oocyte microtubule cytoskeleton polarization
namespace: biological_process
alt_id: GO:0048129
def: "Establishment and maintenance of a specific axis of polarity of the oocyte microtubule network. The axis is set so that the minus and plus ends of the microtubules of the mid stage oocyte are positioned along the anterior cortex and at the posterior pole, respectively. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11807042]
is_a: GO:0007017 ! microtubule-based process
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
relationship: part_of GO:0007309 ! oocyte axis specification
relationship: part_of GO:0016325 ! oocyte microtubule cytoskeleton organization

[Term]
id: GO:0008104
name: protein localization
namespace: biological_process
def: "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]
subset: gosubset_prok
synonym: "establishment and maintenance of protein localization" EXACT []
synonym: "protein localisation" EXACT [GOC:mah]
is_a: GO:0033036 ! macromolecule localization

[Term]
id: GO:0008105
name: asymmetric protein localization
namespace: biological_process
def: "Any process in which a protein is transported to, or maintained in, a specific location such that it is distributed asymmetrically." [GOC:ma]
subset: gosubset_prok
synonym: "asymmetric protein localisation" EXACT [GOC:mah]
synonym: "establishment and maintenance of asymmetric protein localization" EXACT []
is_a: GO:0008104 ! protein localization

[Term]
id: GO:0008106
name: alcohol dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+." [EC:1.1.1.2]
subset: gosubset_prok
synonym: "alcohol:NADP dehydrogenase activity" EXACT []
synonym: "aldehyde reductase (NADPH) activity" EXACT [EC:1.1.1.2]
synonym: "aldehyde reductase (NADPH2) activity" EXACT []
synonym: "NADP-aldehyde reductase activity" EXACT []
xref: EC:1.1.1.2
xref: MetaCyc:ALCOHOL-DEHYDROGENASE-NADP+-RXN
is_a: GO:0004033 ! aldo-keto reductase (NADP) activity

[Term]
id: GO:0008107
name: galactoside 2-alpha-L-fucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-R = GDP + alpha-L-fucosyl-(1,2)-beta-D-galactosyl-R." [EC:2.4.1.69]
subset: gosubset_prok
synonym: "alpha(1,2)-L-fucosyltransferase activity" EXACT []
synonym: "alpha-(1->2)-L-fucosyltransferase activity" EXACT [EC:2.4.1.69]
synonym: "alpha-2-fucosyltransferase activity" EXACT [EC:2.4.1.69]
synonym: "alpha-2-L-fucosyltransferase activity" EXACT [EC:2.4.1.69]
synonym: "beta-galactoside alpha-1->2 fucosyltransferase activity" EXACT [EC:2.4.1.69]
synonym: "beta-galactoside alpha1->2 fucosyltransferase activity" EXACT [EC:2.4.1.69]
synonym: "blood group H alpha-2-fucosyltransferase activity" NARROW [EC:2.4.1.69]
synonym: "blood-group substance H-dependent fucosyltransferase activity" NARROW [EC:2.4.1.69]
synonym: "galactoside 2-L-fucosyltransferase activity" EXACT [EC:2.4.1.69]
synonym: "GDP fucose-lactose fucosyltransferase activity" EXACT [EC:2.4.1.69]
synonym: "GDP-beta-L-fucose:beta-D-galactosyl-R 2-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.69]
synonym: "GDP-L-fucose:lactose fucosyltransferase activity" EXACT [EC:2.4.1.69]
synonym: "guanosine diphospho-L-fucose-lactose fucosyltransferase activity" EXACT [EC:2.4.1.69]
synonym: "guanosine diphosphofucose-beta-D-galactosyl-alpha-2-L-fucosyltransferase activity" EXACT [EC:2.4.1.69]
synonym: "guanosine diphosphofucose-galactoside 2-L-fucosyltransferase activity" EXACT [EC:2.4.1.69]
synonym: "guanosine diphosphofucose-galactosylacetylglucosaminylgalactosyl-glucosylceramide alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.69]
synonym: "guanosine diphosphofucose-galactosylacetylglucosaminylgalactosylglucosylceramide alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.69]
synonym: "guanosine diphosphofucose-glycoprotein 2-alpha-fucosyltransferase activity" EXACT [EC:2.4.1.69]
synonym: "guanosine diphosphofucose-glycoprotein 2-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.69]
synonym: "guanosine diphosphofucose-lactose fucosyltransferase activity" EXACT [EC:2.4.1.69]
synonym: "H-gene-encoded beta-galactoside alpha-1->2 fucosyltransferase activity" NARROW [EC:2.4.1.69]
synonym: "H-gene-encoded beta-galactoside alpha1->2 fucosyltransferase activity" EXACT [EC:2.4.1.69]
synonym: "secretor-type beta-galactoside alpha-1->2 fucosyltransferase activity" NARROW [EC:2.4.1.69]
synonym: "secretor-type beta-galactoside alpha1->2 fucosyltransferase activity" EXACT [EC:2.4.1.69]
xref: EC:2.4.1.69
xref: MetaCyc:GALACTOSIDE-2-L-FUCOSYLTRANSFERASE-RXN
xref: RHEA:24431
is_a: GO:0031127 ! alpha-(1,2)-fucosyltransferase activity

[Term]
id: GO:0008108
name: UDP-glucose:hexose-1-phosphate uridylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-galactose 1-phosphate + UDP-D-glucose = alpha-D-glucose 1-phosphate + UDP-D-galactose." [EC:2.7.7.12, RHEA:13992]
subset: gosubset_prok
synonym: "Gal-1-P uridylyltransferase activity" BROAD [EC:2.7.7.12]
synonym: "galactose-1-phosphate uridylyltransferase activity" BROAD [EC:2.7.7.12]
synonym: "hexose 1-phosphate uridyltransferase activity" EXACT [EC:2.7.7.12]
synonym: "hexose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.12]
synonym: "UDP-glucose-hexose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.12]
synonym: "UDP-glucose:alpha-D-galactose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.12]
synonym: "UDPglucose-hexose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.12]
synonym: "UDPglucose:alpha-D-galactose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.12]
synonym: "uridyl transferase activity" BROAD [EC:2.7.7.12]
synonym: "uridyltransferase activity" EXACT [EC:2.7.7.12]
synonym: "uridylyl removing enzyme activity" BROAD [EC:2.7.7.12]
xref: EC:2.7.7.12
xref: KEGG:R00955
xref: MetaCyc:GALACTURIDYLYLTRANS-RXN
xref: Reactome:REACT_100047 "D-galactose 1-phosphate + UDP-glucose <=> D-glucose 1-phosphate + UDP-galactose, Mus musculus"
xref: Reactome:REACT_101214 "D-galactose 1-phosphate + UDP-glucose <=> D-glucose 1-phosphate + UDP-galactose, Mycobacterium tuberculosis"
xref: Reactome:REACT_105828 "D-galactose 1-phosphate + UDP-glucose <=> D-glucose 1-phosphate + UDP-galactose, Sus scrofa"
xref: Reactome:REACT_105956 "D-galactose 1-phosphate + UDP-glucose <=> D-glucose 1-phosphate + UDP-galactose, Schizosaccharomyces pombe"
xref: Reactome:REACT_108028 "D-galactose 1-phosphate + UDP-glucose <=> D-glucose 1-phosphate + UDP-galactose, Xenopus tropicalis"
xref: Reactome:REACT_110629 "D-galactose 1-phosphate + UDP-glucose <=> D-glucose 1-phosphate + UDP-galactose, Danio rerio"
xref: Reactome:REACT_2047 "D-galactose 1-phosphate + UDP-glucose <=> D-glucose 1-phosphate + UDP-galactose, Homo sapiens"
xref: Reactome:REACT_28172 "D-galactose 1-phosphate + UDP-glucose <=> D-glucose 1-phosphate + UDP-galactose, Caenorhabditis elegans"
xref: Reactome:REACT_28675 "D-galactose 1-phosphate + UDP-glucose <=> D-glucose 1-phosphate + UDP-galactose, Oryza sativa"
xref: Reactome:REACT_30544 "D-galactose 1-phosphate + UDP-glucose <=> D-glucose 1-phosphate + UDP-galactose, Saccharomyces cerevisiae"
xref: Reactome:REACT_32355 "D-galactose 1-phosphate + UDP-glucose <=> D-glucose 1-phosphate + UDP-galactose, Canis familiaris"
xref: Reactome:REACT_77202 "D-galactose 1-phosphate + UDP-glucose <=> D-glucose 1-phosphate + UDP-galactose, Drosophila melanogaster"
xref: Reactome:REACT_85526 "D-galactose 1-phosphate + UDP-glucose <=> D-glucose 1-phosphate + UDP-galactose, Taeniopygia guttata"
xref: Reactome:REACT_88646 "D-galactose 1-phosphate + UDP-glucose <=> D-glucose 1-phosphate + UDP-galactose, Escherichia coli"
xref: Reactome:REACT_95820 "D-galactose 1-phosphate + UDP-glucose <=> D-glucose 1-phosphate + UDP-galactose, Rattus norvegicus"
xref: Reactome:REACT_98248 "D-galactose 1-phosphate + UDP-glucose <=> D-glucose 1-phosphate + UDP-galactose, Bos taurus"
xref: Reactome:REACT_99172 "D-galactose 1-phosphate + UDP-glucose <=> D-glucose 1-phosphate + UDP-galactose, Arabidopsis thaliana"
xref: RHEA:13992
is_a: GO:0070569 ! uridylyltransferase activity

[Term]
id: GO:0008109
name: N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R." [EC:2.4.1.150]
synonym: "galbeta1->4GlcNAc-R beta1->6 N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.150]
synonym: "N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.150]
synonym: "N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase activity" EXACT [EC:2.4.1.150]
synonym: "UDP-GlcNAc:Gal-R, beta-D-6-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.150]
synonym: "UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminide beta-1,6-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.150]
synonym: "uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->6-acetylglucosaminyltransferase" BROAD [EC:2.4.1.150]
xref: EC:2.4.1.150
xref: MetaCyc:2.4.1.150-RXN
xref: RHEA:17416
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0008110
name: L-histidine:2-oxoglutarate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + L-histidine = 3-(imidazol-5-yl)pyruvate + L-glutamate." [EC:2.6.1.38, RHEA:16568]
synonym: "histidine aminotransferase activity" BROAD []
synonym: "histidine transaminase activity" BROAD [EC:2.6.1.38]
synonym: "histidine-2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.38]
xref: EC:2.6.1.38
xref: KEGG:R01161
xref: MetaCyc:HISTTRANSAM-RXN
xref: RHEA:16568
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0008111
name: alpha-methylacyl-CoA racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2S)-2-methylacyl-CoA = (2R)-2-methylacyl-CoA." [EC:5.1.99.4]
subset: gosubset_prok
synonym: "2-methylacyl-CoA 2-epimerase activity" EXACT [EC:5.1.99.4]
xref: EC:5.1.99.4
xref: MetaCyc:5.1.99.4-RXN
xref: Reactome:REACT_100353 "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA, Canis familiaris"
xref: Reactome:REACT_10047 "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA, Homo sapiens"
xref: Reactome:REACT_100693 "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA, Xenopus tropicalis"
xref: Reactome:REACT_100911 "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA, Taeniopygia guttata"
xref: Reactome:REACT_101137 "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA, Danio rerio"
xref: Reactome:REACT_10132 "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA, Homo sapiens"
xref: Reactome:REACT_101411 "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA, Canis familiaris"
xref: Reactome:REACT_101856 "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA, Sus scrofa"
xref: Reactome:REACT_102257 "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA, Mus musculus"
xref: Reactome:REACT_102527 "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA, Drosophila melanogaster"
xref: Reactome:REACT_102774 "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA, Gallus gallus"
xref: Reactome:REACT_103733 "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA, Caenorhabditis elegans"
xref: Reactome:REACT_105187 "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA, Gallus gallus"
xref: Reactome:REACT_106343 "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA, Mycobacterium tuberculosis"
xref: Reactome:REACT_106950 "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA, Sus scrofa"
xref: Reactome:REACT_108019 "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA, Bos taurus"
xref: Reactome:REACT_109362 "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA, Taeniopygia guttata"
xref: Reactome:REACT_109677 "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA, Sus scrofa"
xref: Reactome:REACT_110602 "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA, Rattus norvegicus"
xref: Reactome:REACT_17018 "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA, Homo sapiens"
xref: Reactome:REACT_28117 "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA, Drosophila melanogaster"
xref: Reactome:REACT_28924 "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA, Mus musculus"
xref: Reactome:REACT_29967 "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA, Xenopus tropicalis"
xref: Reactome:REACT_30482 "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA, Danio rerio"
xref: Reactome:REACT_32351 "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA, Bos taurus"
xref: Reactome:REACT_32645 "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA, Danio rerio"
xref: Reactome:REACT_33057 "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA, Taeniopygia guttata"
xref: Reactome:REACT_33474 "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA, Rattus norvegicus"
xref: Reactome:REACT_33603 "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA, Xenopus tropicalis"
xref: Reactome:REACT_37409 "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA, Canis familiaris"
xref: Reactome:REACT_71046 "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA, Sus scrofa"
xref: Reactome:REACT_78611 "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA, Danio rerio"
xref: Reactome:REACT_78993 "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA, Taeniopygia guttata"
xref: Reactome:REACT_79020 "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA, Caenorhabditis elegans"
xref: Reactome:REACT_79836 "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA, Bos taurus"
xref: Reactome:REACT_80570 "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA, Danio rerio"
xref: Reactome:REACT_80995 "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA, Rattus norvegicus"
xref: Reactome:REACT_82038 "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA, Caenorhabditis elegans"
xref: Reactome:REACT_82358 "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA, Mycobacterium tuberculosis"
xref: Reactome:REACT_82811 "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA, Rattus norvegicus"
xref: Reactome:REACT_83537 "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA, Gallus gallus"
xref: Reactome:REACT_83768 "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA, Mus musculus"
xref: Reactome:REACT_84220 "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA, Taeniopygia guttata"
xref: Reactome:REACT_84868 "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA, Xenopus tropicalis"
xref: Reactome:REACT_85691 "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA, Drosophila melanogaster"
xref: Reactome:REACT_85692 "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA, Caenorhabditis elegans"
xref: Reactome:REACT_85932 "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA, Mycobacterium tuberculosis"
xref: Reactome:REACT_86099 "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA, Drosophila melanogaster"
xref: Reactome:REACT_88102 "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA, Xenopus tropicalis"
xref: Reactome:REACT_88134 "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA, Gallus gallus"
xref: Reactome:REACT_89541 "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA, Canis familiaris"
xref: Reactome:REACT_89756 "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA, Caenorhabditis elegans"
xref: Reactome:REACT_89818 "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA, Canis familiaris"
xref: Reactome:REACT_89909 "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA, Mycobacterium tuberculosis"
xref: Reactome:REACT_91143 "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA, Mycobacterium tuberculosis"
xref: Reactome:REACT_96451 "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA, Gallus gallus"
xref: Reactome:REACT_96839 "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA, Mus musculus"
xref: Reactome:REACT_96887 "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA, Bos taurus"
xref: Reactome:REACT_97059 "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA, Bos taurus"
xref: Reactome:REACT_97244 "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA, Drosophila melanogaster"
xref: Reactome:REACT_97407 "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA, Sus scrofa"
xref: Reactome:REACT_98569 "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA, Mus musculus"
xref: Reactome:REACT_98767 "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA, Rattus norvegicus"
xref: Reactome:REACT_9964 "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA, Homo sapiens"
xref: Reactome:REACT_9998 "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA, Homo sapiens"
xref: RHEA:12660
is_a: GO:0016854 ! racemase and epimerase activity

[Term]
id: GO:0008112
name: nicotinamide N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nicotinamide = 1-methylnicotinamide + S-adenosyl-L-homocysteine." [EC:2.1.1.1, RHEA:23887]
subset: gosubset_prok
synonym: "nicotinamide methyltransferase activity" EXACT [EC:2.1.1.1]
synonym: "S-adenosyl-L-methionine:nicotinamide N-methyltransferase activity" EXACT [EC:2.1.1.1]
xref: EC:2.1.1.1
xref: KEGG:R01269
xref: MetaCyc:NICOTINAMIDE-N-METHYLTRANSFERASE-RXN
xref: RHEA:23887
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0008113
name: peptide-methionine (S)-S-oxide reductase activity
namespace: molecular_function
alt_id: GO:0033742
alt_id: GO:0072561
def: "Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the S enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.8.4.11, GOC:mah, GOC:vw, PMID:11169920]
subset: gosubset_prok
synonym: "methionine S-oxide reductase (S-form oxidizing) activity" EXACT [EC:1.8.4.11]
synonym: "methionine S-oxide reductase activity" BROAD [EC:1.8.4.11]
synonym: "methionine sulfoxide (protein) reductase activity" EXACT []
synonym: "methionine sulfoxide reductase A activity" EXACT [EC:1.8.4.11]
synonym: "methionine sulfoxide reductase activity" BROAD [EC:1.8.4.11]
synonym: "methionine sulphoxide reductase A activity" EXACT [EC:1.8.4.11]
synonym: "MsrA" RELATED [EC:1.8.4.11]
synonym: "peptide Met(O) reductase activity" EXACT [EC:1.8.4.11]
synonym: "peptide methionine sulfoxide reductase activity" EXACT [EC:1.8.4.11]
synonym: "peptide-L-methionine:thioredoxin-disulfide S-oxidoreductase [L-methionine (S)-S-oxide-forming] activity" EXACT [EC:1.8.4.11]
synonym: "peptide-methionine-(S)-S-oxide reductase activity" EXACT []
synonym: "protein-methionine-S-oxide reductase activity" EXACT []
xref: EC:1.8.4.-
xref: EC:1.8.4.11
xref: MetaCyc:RXN-8668
xref: MetaCyc:RXN-8669
is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor

[Term]
id: GO:0008114
name: phosphogluconate 2-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = 6-phospho-2-dehydro-D-gluconate + NADPH." [EC:1.1.1.43]
synonym: "2-keto-6-phosphogluconate reductase activity" EXACT [EC:1.1.1.43]
synonym: "6-phospho-D-gluconate:NAD(P)+ 2-oxidoreductase activity" EXACT [EC:1.1.1.43]
synonym: "6-phosphogluconate 2-dehydrogenase activity" EXACT []
synonym: "6-phosphogluconate dehydrogenase (NAD)" EXACT [EC:1.1.1.43]
synonym: "6-phosphogluconic dehydrogenase activity" BROAD [EC:1.1.1.43]
synonym: "gluconate 6-phosphate dehydrogenase activity" EXACT [EC:1.1.1.43]
synonym: "phosphogluconate dehydrogenase activity" EXACT [EC:1.1.1.43]
xref: EC:1.1.1.43
xref: MetaCyc:1.1.1.43-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008115
name: sarcosine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + O(2) + sarcosine = formaldehyde + glycine + H(2)O(2)." [EC:1.5.3.1, RHEA:13316]
subset: gosubset_prok
synonym: "sarcosine:oxygen oxidoreductase (demethylating)" EXACT [EC:1.5.3.1]
xref: EC:1.5.3.1
xref: KEGG:R00610
xref: MetaCyc:SARCOX-RXN
xref: RHEA:13316
is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor

[Term]
id: GO:0008116
name: prostaglandin-I synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: prostaglandin H(2) = prostaglandin I(2)." [EC:5.3.99.4, RHEA:23583]
synonym: "(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate 6-isomerase activity" EXACT [EC:5.3.99.4]
synonym: "cytochrome P450 CYP8A1" NARROW []
synonym: "PGI(2) synthase activity" EXACT [EC:5.3.99.4]
synonym: "PGI(2) synthetase activity" EXACT [EC:5.3.99.4]
synonym: "PGI2 synthase activity" EXACT [EC:5.3.99.4]
synonym: "PGI2 synthetase activity" EXACT [EC:5.3.99.4]
synonym: "prostacyclin synthase activity" EXACT [EC:5.3.99.4]
synonym: "prostacycline synthetase activity" EXACT [EC:5.3.99.4]
synonym: "prostagladin I2 synthetase activity" EXACT [EC:5.3.99.4]
xref: EC:5.3.99.4
xref: KEGG:R02267
xref: MetaCyc:PROSTAGLANDIN-I-SYNTHASE-RXN
xref: Reactome:REACT_100289 "Prostacyclin synthase (CYP8A1) mediates the isomerization of prostaglandin H2 to prostaglandin I2, Danio rerio"
xref: Reactome:REACT_106222 "Prostacyclin synthase (CYP8A1) mediates the isomerization of prostaglandin H2 to prostaglandin I2, Rattus norvegicus"
xref: Reactome:REACT_112323 "Prostacyclin synthase (CYP8A1) mediates the isomerization of prostaglandin H2 to prostaglandin I2, Mycobacterium tuberculosis"
xref: Reactome:REACT_113532 "Prostacyclin synthase (CYP8A1) mediates the isomerization of prostaglandin H2 to prostaglandin I2, Arabidopsis thaliana"
xref: Reactome:REACT_114097 "Prostacyclin synthase (CYP8A1) mediates the isomerization of prostaglandin H2 to prostaglandin I2, Dictyostelium discoideum"
xref: Reactome:REACT_114523 "Prostacyclin synthase (CYP8A1) mediates the isomerization of prostaglandin H2 to prostaglandin I2, Oryza sativa"
xref: Reactome:REACT_1841 "Prostacyclin synthase (CYP8A1) mediates the isomerization of prostaglandin H2 to prostaglandin I2, Homo sapiens"
xref: Reactome:REACT_48973 "Prostacyclin synthase (CYP8A1) mediates the isomerization of prostaglandin H2 to prostaglandin I2, Sus scrofa"
xref: Reactome:REACT_82333 "Prostacyclin synthase (CYP8A1) mediates the isomerization of prostaglandin H2 to prostaglandin I2, Mus musculus"
xref: Reactome:REACT_83977 "Prostacyclin synthase (CYP8A1) mediates the isomerization of prostaglandin H2 to prostaglandin I2, Bos taurus"
xref: Reactome:REACT_87732 "Prostacyclin synthase (CYP8A1) mediates the isomerization of prostaglandin H2 to prostaglandin I2, Canis familiaris"
xref: Reactome:REACT_96947 "Prostacyclin synthase (CYP8A1) mediates the isomerization of prostaglandin H2 to prostaglandin I2, Xenopus tropicalis"
xref: RHEA:23583
is_a: GO:0016860 ! intramolecular oxidoreductase activity

[Term]
id: GO:0008117
name: sphinganine-1-phosphate aldolase activity
namespace: molecular_function
alt_id: GO:0016001
def: "Catalysis of the reaction: sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde." [EC:4.1.2.27]
subset: gosubset_prok
synonym: "dihydrosphingosine 1-phosphate aldolase activity" EXACT [EC:4.1.2.27]
synonym: "sphinganine-1-phosphate alkanal-lyase activity" EXACT [EC:4.1.2.27]
synonym: "sphinganine-1-phosphate lyase activity" EXACT [EC:4.1.2.27]
synonym: "sphinganine-1-phosphate palmitaldehyde-lyase (phosphoethanolamine-forming)" EXACT [EC:4.1.2.27]
synonym: "sphinganine-1-phosphate palmitaldehyde-lyase activity" EXACT [EC:4.1.2.27]
synonym: "sphingosine-1-phosphate aldolase activity" EXACT [EC:4.1.2.27]
synonym: "sphingosine-1-phosphate lyase activity" EXACT [EC:4.1.2.27]
xref: EC:4.1.2.27
xref: MetaCyc:SPHINGANINE-1-PHOSPHATE-ALDOLASE-RXN
xref: Reactome:REACT_100339 "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal, Rattus norvegicus"
xref: Reactome:REACT_101981 "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal, Saccharomyces cerevisiae"
xref: Reactome:REACT_104727 "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal, Mus musculus"
xref: Reactome:REACT_104827 "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal, Bos taurus"
xref: Reactome:REACT_105590 "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal, Rattus norvegicus"
xref: Reactome:REACT_105964 "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal, Taeniopygia guttata"
xref: Reactome:REACT_106609 "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal, Dictyostelium discoideum"
xref: Reactome:REACT_107085 "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal, Drosophila melanogaster"
xref: Reactome:REACT_108278 "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal, Bos taurus"
xref: Reactome:REACT_108884 "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal, Canis familiaris"
xref: Reactome:REACT_109932 "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal, Arabidopsis thaliana"
xref: Reactome:REACT_113234 "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal, Caenorhabditis elegans"
xref: Reactome:REACT_113298 "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal, Escherichia coli"
xref: Reactome:REACT_113335 "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal, Caenorhabditis elegans"
xref: Reactome:REACT_114175 "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal, Escherichia coli"
xref: Reactome:REACT_19349 "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal, Homo sapiens"
xref: Reactome:REACT_19379 "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal, Homo sapiens"
xref: Reactome:REACT_28648 "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal, Mus musculus"
xref: Reactome:REACT_29135 "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal, Mycobacterium tuberculosis"
xref: Reactome:REACT_33610 "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal, Xenopus tropicalis"
xref: Reactome:REACT_33893 "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal, Dictyostelium discoideum"
xref: Reactome:REACT_81090 "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal, Gallus gallus"
xref: Reactome:REACT_81334 "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal, Mycobacterium tuberculosis"
xref: Reactome:REACT_81902 "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal, Sus scrofa"
xref: Reactome:REACT_82463 "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal, Drosophila melanogaster"
xref: Reactome:REACT_86549 "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal, Gallus gallus"
xref: Reactome:REACT_86997 "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal, Saccharomyces cerevisiae"
xref: Reactome:REACT_87314 "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal, Arabidopsis thaliana"
xref: Reactome:REACT_87796 "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal, Canis familiaris"
xref: Reactome:REACT_87913 "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal, Danio rerio"
xref: Reactome:REACT_89278 "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal, Oryza sativa"
xref: Reactome:REACT_90247 "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal, Danio rerio"
xref: Reactome:REACT_90739 "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal, Taeniopygia guttata"
xref: Reactome:REACT_90916 "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal, Oryza sativa"
xref: Reactome:REACT_91012 "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal, Sus scrofa"
xref: Reactome:REACT_96251 "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal, Xenopus tropicalis"
xref: RHEA:18596
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0008118
name: N-acetyllactosaminide alpha-2,3-sialyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein." [EC:2.4.99.6]
synonym: "alpha2->3 sialyltransferase activity" EXACT [EC:2.4.99.6]
synonym: "CMP-N-acetylneuraminate:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein alpha-2,3-N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.6]
synonym: "cytidine monophosphoacetylneuraminate-beta-galactosyl(1->4)acetylglucosaminide alpha2->3-sialyltransferase activity" EXACT [EC:2.4.99.6]
synonym: "SiaT" RELATED [EC:2.4.99.6]
xref: EC:2.4.99.6
xref: MetaCyc:2.4.99.6-RXN
xref: RHEA:15572
is_a: GO:0008373 ! sialyltransferase activity

[Term]
id: GO:0008119
name: thiopurine S-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether." [EC:2.1.1.67]
subset: gosubset_prok
synonym: "6-thiopurine transmethylase activity" EXACT [EC:2.1.1.67]
synonym: "mercaptopurine methyltransferase activity" EXACT [EC:2.1.1.67]
synonym: "S-adenosyl-L-methionine:thiopurine S-methyltransferase activity" EXACT [EC:2.1.1.67]
synonym: "thiopurine methyltransferase activity" EXACT [EC:2.1.1.67]
synonym: "TPMT" RELATED [EC:2.1.1.67]
xref: EC:2.1.1.67
xref: MetaCyc:THIOPURINE-S-METHYLTRANSFERASE-RXN
xref: Reactome:REACT_102303 "6-mercaptopurine can be S-methylated, Bos taurus"
xref: Reactome:REACT_103452 "6-mercaptopurine can be S-methylated, Danio rerio"
xref: Reactome:REACT_29153 "6-mercaptopurine can be S-methylated, Gallus gallus"
xref: Reactome:REACT_29397 "6-mercaptopurine can be S-methylated, Taeniopygia guttata"
xref: Reactome:REACT_30624 "6-mercaptopurine can be S-methylated, Sus scrofa"
xref: Reactome:REACT_6779 "6-mercaptopurine can be S-methylated, Homo sapiens"
xref: Reactome:REACT_78026 "6-mercaptopurine can be S-methylated, Canis familiaris"
xref: Reactome:REACT_89240 "6-mercaptopurine can be S-methylated, Xenopus tropicalis"
xref: Reactome:REACT_94803 "6-mercaptopurine can be S-methylated, Rattus norvegicus"
xref: Reactome:REACT_99400 "6-mercaptopurine can be S-methylated, Mus musculus"
is_a: GO:0008172 ! S-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0008120
name: ceramide glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + N-acylsphingosine = UDP + D-glucosyl-N-acylsphingosine." [EC:2.4.1.80]
subset: gosubset_prok
synonym: "ceramide:UDP-glucose glucosyltransferase activity" EXACT [EC:2.4.1.80]
synonym: "ceramide:UDPGlc glucosyltransferase activity" EXACT [EC:2.4.1.80]
synonym: "glucosylceramide synthase activity" EXACT [EC:2.4.1.80]
synonym: "UDP-glucose-ceramide glucosyltransferase activity" EXACT [EC:2.4.1.80]
synonym: "UDP-glucose:ceramide glucosyltransferase activity" EXACT [EC:2.4.1.80]
synonym: "UDP-glucose:N-acylsphingosine D-glucosyltransferase activity" EXACT [EC:2.4.1.80]
synonym: "UDPglucose:N-acylsphingosine D-glucosyltransferase activity" EXACT [EC:2.4.1.80]
synonym: "uridine diphosphoglucose-ceramide glucosyltransferase activity" EXACT [EC:2.4.1.80]
xref: EC:2.4.1.80
xref: MetaCyc:CERAMIDE-GLUCOSYLTRANSFERASE-RXN
xref: Reactome:REACT_115635 "Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide, Homo sapiens"
xref: RHEA:12091
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0008121
name: ubiquinol-cytochrome-c reductase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+." [EC:1.10.2.2, ISBN:0198547684]
subset: gosubset_prok
synonym: "coenzyme Q-cytochrome c reductase activity" EXACT [EC:1.10.2.2]
synonym: "coenzyme QH2-cytochrome c reductase activity" EXACT [EC:1.10.2.2]
synonym: "complex III (mitochondrial electron transport) activity" NARROW [EC:1.10.2.2]
synonym: "CoQH2-cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2]
synonym: "cytochrome bc1 complex" RELATED []
synonym: "dihydrocoenzyme Q-cytochrome c reductase activity" EXACT [EC:1.10.2.2]
synonym: "mitochondrial electron transport complex III" RELATED [EC:1.10.2.2]
synonym: "QH2:cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2]
synonym: "reduced coenzyme Q-cytochrome c reductase activity" EXACT [EC:1.10.2.2]
synonym: "reduced ubiquinone-cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2]
synonym: "reduced ubiquinone-cytochrome c reductase, complex III (mitochondrial electron transport)" RELATED [EC:1.10.2.2]
synonym: "ubihydroquinol:cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2]
synonym: "ubiquinol-cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2]
synonym: "ubiquinol-cytochrome c-2 oxidoreductase activity" EXACT [EC:1.10.2.2]
synonym: "ubiquinol-cytochrome c1 oxidoreductase activity" EXACT [EC:1.10.2.2]
synonym: "ubiquinol-cytochrome c2 reductase activity" EXACT [EC:1.10.2.2]
synonym: "ubiquinol:ferricytochrome-c oxidoreductase activity" EXACT [EC:1.10.2.2]
synonym: "ubiquinone--cytochrome-c oxidoreductase activity" EXACT [EC:1.10.2.2]
synonym: "ubiquinone-cytochrome b-c1 oxidoreductase activity" EXACT []
synonym: "ubiquinone-cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2]
synonym: "ubiquinone-cytochrome c reductase activity" EXACT [EC:1.10.2.2]
xref: EC:1.10.2.2
xref: MetaCyc:1.10.2.2-RXN
is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity
is_a: GO:0016681 ! oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor

[Term]
id: GO:0008123
name: cholesterol 7-alpha-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cholesterol + NADPH + H+ + O2 = 7-alpha-hydroxycholesterol + NADP+ + H2O." [EC:1.14.13.17]
synonym: "cholesterol 7-alpha-hydroxylase activity" EXACT []
synonym: "cholesterol 7alpha-hydroxylase activity" EXACT [EC:1.14.13.17]
synonym: "cholesterol 7alpha-monooxygenase activity" EXACT [EC:1.14.13.17]
synonym: "cholesterol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)" EXACT [EC:1.14.13.17]
synonym: "cytochrome P450 CYP7A1" NARROW []
xref: EC:1.14.13.17
xref: MetaCyc:CHOLESTEROL-7-ALPHA-MONOOXYGENASE-RXN
xref: Reactome:REACT_10052 "Cholesterol is hydroxylated to 7alpha-hydroxycholesterol by CYP7A1, Homo sapiens"
xref: Reactome:REACT_108891 "Cholesterol is hydroxylated to 7alpha-hydroxycholesterol by CYP7A1, Bos taurus"
xref: Reactome:REACT_110551 "Cholesterol is hydroxylated to 7alpha-hydroxycholesterol by CYP7A1, Xenopus tropicalis"
xref: Reactome:REACT_112443 "Cholesterol is hydroxylated to 7alpha-hydroxycholesterol by CYP7A1, Mycobacterium tuberculosis"
xref: Reactome:REACT_113215 "Cholesterol is hydroxylated to 7alpha-hydroxycholesterol by CYP7A1, Arabidopsis thaliana"
xref: Reactome:REACT_114538 "Cholesterol is hydroxylated to 7alpha-hydroxycholesterol by CYP7A1, Oryza sativa"
xref: Reactome:REACT_114617 "Cholesterol is hydroxylated to 7alpha-hydroxycholesterol by CYP7A1, Dictyostelium discoideum"
xref: Reactome:REACT_30185 "Cholesterol is hydroxylated to 7alpha-hydroxycholesterol by CYP7A1, Danio rerio"
xref: Reactome:REACT_79018 "Cholesterol is hydroxylated to 7alpha-hydroxycholesterol by CYP7A1, Mus musculus"
xref: Reactome:REACT_79632 "Cholesterol is hydroxylated to 7alpha-hydroxycholesterol by CYP7A1, Sus scrofa"
xref: Reactome:REACT_81654 "Cholesterol is hydroxylated to 7alpha-hydroxycholesterol by CYP7A1, Taeniopygia guttata"
xref: Reactome:REACT_85424 "Cholesterol is hydroxylated to 7alpha-hydroxycholesterol by CYP7A1, Rattus norvegicus"
xref: Reactome:REACT_85529 "Cholesterol is hydroxylated to 7alpha-hydroxycholesterol by CYP7A1, Gallus gallus"
xref: Reactome:REACT_87361 "Cholesterol is hydroxylated to 7alpha-hydroxycholesterol by CYP7A1, Canis familiaris"
xref: RHEA:21815
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0008124
name: 4-alpha-hydroxytetrahydrobiopterin dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H(2)O." [EC:4.2.1.96, RHEA:11923]
subset: gosubset_prok
synonym: "(6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin hydro-lyase [(6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin-forming]" RELATED [EC:4.2.1.96]
synonym: "4-alpha-hydroxy-tetrahydropterin dehydratase activity" EXACT [EC:4.2.1.96]
synonym: "4a-hydroxytetrahydrobiopterin dehydratase activity" EXACT []
synonym: "4a-hydroxytetrahydrobiopterin hydro-lyase activity" EXACT [EC:4.2.1.96]
synonym: "4alpha-hydroxy-tetrahydropterin dehydratase activity" EXACT [EC:4.2.1.96]
synonym: "pterin-4-alpha-carbinolamine dehydratase activity" EXACT []
synonym: "pterin-4a-carbinolamine dehydratase activity" EXACT []
synonym: "pterin-4alpha-carbinolamine dehydratase activity" EXACT [EC:4.2.1.96]
synonym: "tetrahydrobiopterin dehydratase activity" EXACT [EC:4.2.1.96]
xref: EC:4.2.1.96
xref: KEGG:R04734
xref: MetaCyc:RXN-7908
xref: Reactome:REACT_103762 "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O, Taeniopygia guttata"
xref: Reactome:REACT_106786 "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O, Bos taurus"
xref: Reactome:REACT_108010 "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O, Rattus norvegicus"
xref: Reactome:REACT_113243 "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O, Caenorhabditis elegans"
xref: Reactome:REACT_2236 "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O, Homo sapiens"
xref: Reactome:REACT_29622 "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O, Sus scrofa"
xref: Reactome:REACT_29819 "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O, Drosophila melanogaster"
xref: Reactome:REACT_30878 "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O, Canis familiaris"
xref: Reactome:REACT_33618 "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O, Mus musculus"
xref: Reactome:REACT_77816 "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O, Danio rerio"
xref: Reactome:REACT_78306 "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O, Xenopus tropicalis"
xref: RHEA:11923
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0008125
name: obsolete pancreatic elastase I activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of proteins, including elastin. Preferential cleavage: Ala-Xaa." [EC:3.4.21.36]
comment: This term was made obsolete because it represents a gene product.
synonym: "elaszym" RELATED [EC:3.4.21.36]
synonym: "pancreatic elastase I activity" EXACT []
synonym: "pancreatopeptidase E activity" EXACT [EC:3.4.21.36]
synonym: "serine elastase" BROAD [EC:3.4.21.36]
xref: EC:3.4.21.36
xref: MetaCyc:3.4.21.36-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0008126
name: acetylesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: an acetic ester + H2O = an alcohol + acetate." [EC:3.1.1.6]
subset: gosubset_prok
synonym: "acetic ester hydrolase activity" EXACT [EC:3.1.1.6]
synonym: "acetic-ester acetylhydrolase activity" EXACT [EC:3.1.1.6]
synonym: "C-esterase (in animal tissues)" NARROW [EC:3.1.1.6]
synonym: "chloroesterase" NARROW [EC:3.1.1.6]
synonym: "citrus acetylesterase" NARROW [EC:3.1.1.6]
synonym: "p-nitrophenyl acetate esterase" NARROW [EC:3.1.1.6]
xref: EC:3.1.1.6
xref: MetaCyc:ACETYLESTERASE-RXN
xref: UM-BBD_reactionID:r0170
is_a: GO:0034338 ! short-chain carboxylesterase activity

[Term]
id: GO:0008127
name: quercetin 2,3-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(+) + O(2) + quercetin = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO." [EC:1.13.11.24, RHEA:15384]
synonym: "flavonol 2,4-oxygenase activity" EXACT [EC:1.13.11.24]
synonym: "quercetin:oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.24]
synonym: "quercetinase activity" EXACT [EC:1.13.11.24]
xref: EC:1.13.11.24
xref: KEGG:R02156
xref: MetaCyc:QUERCETIN-23-DIOXYGENASE-RXN
xref: RHEA:15384
xref: UM-BBD_reactionID:r0891
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0008129
name: obsolete actinidain activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity for peptide bonds, with preference for a residue bearing a large hydrophobic side chain at the P2 position. Does not accept Val at P1'." [EC:3.4.22.14]
comment: This term was made obsolete because it represents a gene product.
synonym: "actinidain activity" EXACT []
synonym: "actinidia anionic protease activity" NARROW [EC:3.4.22.14]
synonym: "actinidin activity" EXACT [EC:3.4.22.14]
synonym: "proteinase A2 of actinidia chinensis" RELATED [EC:3.4.22.14]
xref: EC:3.4.22.14
xref: MetaCyc:3.4.22.14-RXN
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0008130
name: obsolete neutrophil collagenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of interstitial collagens in the triple helical domain. Unlike EC:3.4.24.7, this enzyme cleaves type III collagen more slowly than type I." [EC:3.4.24.34]
comment: This term was made obsolete because it represents a gene product.
synonym: "matrix metalloproteinase 8 activity" EXACT [EC:3.4.24.34]
synonym: "MMP-8" EXACT []
synonym: "neutrophil collagenase activity" EXACT []
synonym: "PMNL collagenase activity" EXACT [EC:3.4.24.34]
xref: EC:3.4.24.34
xref: MetaCyc:3.4.24.34-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0008131
name: primary amine oxidase activity
namespace: molecular_function
alt_id: GO:0004041
alt_id: GO:0008122
def: "Catalysis of the reaction: a primary amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide." [EC:1.4.3.21, EC:1.4.3.22, EC:1.4.3.4, MetaCyc:RXN-9597]
subset: gosubset_prok
synonym: "amine oxidase (copper-containing) activity" NARROW []
synonym: "amine oxidase activity" BROAD [EC:1.4.3.21]
synonym: "primary-amine:oxygen oxidoreductase (deaminating) activity" EXACT systematic_synonym [EC:1.4.3.21]
xref: EC:1.4.3.21
xref: KEGG:R01853
xref: MetaCyc:RXN-9597
xref: Reactome:REACT_100172 "oxidation of dopamine to 3,4dihydroxyphenylacetic acid (DOPAC), Bos taurus"
xref: Reactome:REACT_100207 "Metabolism of Noradrenaline, Danio rerio"
xref: Reactome:REACT_101077 "Metabolism of Noradrenaline, Taeniopygia guttata"
xref: Reactome:REACT_102408 "Dietary tyramine is oxidatively deaminated to an aldehyde by MAOB, Danio rerio"
xref: Reactome:REACT_103010 "Oxidative deamination of Phenyethylamine by MAOB, Sus scrofa"
xref: Reactome:REACT_103606 "oxidation of dopamine to 3,4dihydroxyphenylacetic acid (DOPAC), Rattus norvegicus"
xref: Reactome:REACT_103666 "Metabolism of Noradrenaline, Rattus norvegicus"
xref: Reactome:REACT_104381 "Oxidation of 3-Methoxytyramine to homovanillic acid, Bos taurus"
xref: Reactome:REACT_104729 "Metabolism of Noradrenaline, Xenopus tropicalis"
xref: Reactome:REACT_105770 "Oxidative deamination of 5-Hydroxytryptamine by MAOA, Rattus norvegicus"
xref: Reactome:REACT_105903 "oxidation of dopamine to 3,4dihydroxyphenylacetic acid (DOPAC), Mycobacterium tuberculosis"
xref: Reactome:REACT_106369 "Dietary tyramine is oxidatively deaminated to an aldehyde by MAOB, Rattus norvegicus"
xref: Reactome:REACT_107640 "Oxidative deamination of Phenyethylamine by MAOB, Mycobacterium tuberculosis"
xref: Reactome:REACT_108025 "Oxidative deamination of Phenyethylamine by MAOB, Xenopus tropicalis"
xref: Reactome:REACT_108532 "Oxidation of 3-Methoxytyramine to homovanillic acid, Mus musculus"
xref: Reactome:REACT_108898 "Metabolism of Noradrenaline, Canis familiaris"
xref: Reactome:REACT_109487 "Oxidation of 3-Methoxytyramine to homovanillic acid, Canis familiaris"
xref: Reactome:REACT_110139 "Oxidative deamination of Phenyethylamine by MAOB, Gallus gallus"
xref: Reactome:REACT_112132 "Oxidative deamination of 5-Hydroxytryptamine by MAOA, Dictyostelium discoideum"
xref: Reactome:REACT_112188 "oxidation of dopamine to 3,4dihydroxyphenylacetic acid (DOPAC), Dictyostelium discoideum"
xref: Reactome:REACT_112919 "Oxidative deamination of Phenyethylamine by MAOB, Dictyostelium discoideum"
xref: Reactome:REACT_113622 "Dietary tyramine is oxidatively deaminated to an aldehyde by MAOB, Dictyostelium discoideum"
xref: Reactome:REACT_114320 "Oxidation of 3-Methoxytyramine to homovanillic acid, Dictyostelium discoideum"
xref: Reactome:REACT_115498 "Metabolism of Noradrenaline, Dictyostelium discoideum"
xref: Reactome:REACT_1260 "Dietary tyramine is oxidatively deaminated to an aldehyde by MAOB, Homo sapiens"
xref: Reactome:REACT_15390 "Metabolism of Noradrenaline, Homo sapiens"
xref: Reactome:REACT_15434 "Oxidation of 3-Methoxytyramine to homovanillic acid, Homo sapiens"
xref: Reactome:REACT_15485 "oxidation of dopamine to 3,4dihydroxyphenylacetic acid (DOPAC), Homo sapiens"
xref: Reactome:REACT_1795 "Oxidative deamination of 5-Hydroxytryptamine by MAOA, Homo sapiens"
xref: Reactome:REACT_30062 "Oxidative deamination of 5-Hydroxytryptamine by MAOA, Gallus gallus"
xref: Reactome:REACT_31086 "oxidation of dopamine to 3,4dihydroxyphenylacetic acid (DOPAC), Canis familiaris"
xref: Reactome:REACT_31747 "Oxidation of 3-Methoxytyramine to homovanillic acid, Rattus norvegicus"
xref: Reactome:REACT_32073 "Dietary tyramine is oxidatively deaminated to an aldehyde by MAOB, Bos taurus"
xref: Reactome:REACT_32275 "Oxidative deamination of 5-Hydroxytryptamine by MAOA, Canis familiaris"
xref: Reactome:REACT_33881 "oxidation of dopamine to 3,4dihydroxyphenylacetic acid (DOPAC), Sus scrofa"
xref: Reactome:REACT_33889 "Oxidative deamination of Phenyethylamine by MAOB, Rattus norvegicus"
xref: Reactome:REACT_57518 "Metabolism of Noradrenaline, Gallus gallus"
xref: Reactome:REACT_77250 "Oxidation of 3-Methoxytyramine to homovanillic acid, Xenopus tropicalis"
xref: Reactome:REACT_77459 "Dietary tyramine is oxidatively deaminated to an aldehyde by MAOB, Mycobacterium tuberculosis"
xref: Reactome:REACT_78278 "Oxidation of 3-Methoxytyramine to homovanillic acid, Danio rerio"
xref: Reactome:REACT_78447 "Oxidative deamination of 5-Hydroxytryptamine by MAOA, Sus scrofa"
xref: Reactome:REACT_81091 "Oxidation of 3-Methoxytyramine to homovanillic acid, Mycobacterium tuberculosis"
xref: Reactome:REACT_81786 "Oxidative deamination of Phenyethylamine by MAOB, Bos taurus"
xref: Reactome:REACT_82325 "oxidation of dopamine to 3,4dihydroxyphenylacetic acid (DOPAC), Danio rerio"
xref: Reactome:REACT_83353 "Oxidation of 3-Methoxytyramine to homovanillic acid, Taeniopygia guttata"
xref: Reactome:REACT_83430 "Oxidation of 3-Methoxytyramine to homovanillic acid, Sus scrofa"
xref: Reactome:REACT_84216 "Oxidative deamination of 5-Hydroxytryptamine by MAOA, Mycobacterium tuberculosis"
xref: Reactome:REACT_85119 "oxidation of dopamine to 3,4dihydroxyphenylacetic acid (DOPAC), Taeniopygia guttata"
xref: Reactome:REACT_86644 "Oxidative deamination of Phenyethylamine by MAOB, Mus musculus"
xref: Reactome:REACT_87838 "Metabolism of Noradrenaline, Bos taurus"
xref: Reactome:REACT_87899 "Oxidative deamination of Phenyethylamine by MAOB, Canis familiaris"
xref: Reactome:REACT_89444 "Oxidative deamination of 5-Hydroxytryptamine by MAOA, Bos taurus"
xref: Reactome:REACT_90506 "Metabolism of Noradrenaline, Mycobacterium tuberculosis"
xref: Reactome:REACT_91406 "Dietary tyramine is oxidatively deaminated to an aldehyde by MAOB, Taeniopygia guttata"
xref: Reactome:REACT_92185 "Oxidative deamination of Phenyethylamine by MAOB, Danio rerio"
xref: Reactome:REACT_93202 "Oxidative deamination of 5-Hydroxytryptamine by MAOA, Xenopus tropicalis"
xref: Reactome:REACT_93997 "Oxidation of 3-Methoxytyramine to homovanillic acid, Gallus gallus"
xref: Reactome:REACT_94129 "Oxidative deamination of Phenyethylamine by MAOB, Taeniopygia guttata"
xref: Reactome:REACT_94583 "Metabolism of Noradrenaline, Sus scrofa"
xref: Reactome:REACT_95338 "oxidation of dopamine to 3,4dihydroxyphenylacetic acid (DOPAC), Gallus gallus"
xref: Reactome:REACT_96306 "Oxidative deamination of 5-Hydroxytryptamine by MAOA, Mus musculus"
xref: Reactome:REACT_96849 "oxidation of dopamine to 3,4dihydroxyphenylacetic acid (DOPAC), Xenopus tropicalis"
xref: Reactome:REACT_97385 "Dietary tyramine is oxidatively deaminated to an aldehyde by MAOB, Xenopus tropicalis"
xref: Reactome:REACT_980 "Oxidative deamination of Phenyethylamine by MAOB, Homo sapiens"
xref: Reactome:REACT_98280 "Dietary tyramine is oxidatively deaminated to an aldehyde by MAOB, Canis familiaris"
xref: Reactome:REACT_98340 "Oxidative deamination of 5-Hydroxytryptamine by MAOA, Taeniopygia guttata"
xref: Reactome:REACT_98597 "oxidation of dopamine to 3,4dihydroxyphenylacetic acid (DOPAC), Mus musculus"
xref: Reactome:REACT_98940 "Dietary tyramine is oxidatively deaminated to an aldehyde by MAOB, Mus musculus"
xref: Reactome:REACT_99002 "Metabolism of Noradrenaline, Mus musculus"
xref: Reactome:REACT_99366 "Oxidative deamination of 5-Hydroxytryptamine by MAOA, Danio rerio"
is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

[Term]
id: GO:0008132
name: obsolete pancreatic elastase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of proteins, including elastin." [EC:3.4.21.36, EC:3.4.21.71]
comment: This term was made obsolete because it represents a gene product.
synonym: "pancreatic elastase activity" EXACT []
xref: EC:3.4.21.-
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0008133
name: obsolete collagenase activity
namespace: molecular_function
def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "collagenase activity" EXACT []
xref: EC:3.4.24.-
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0008134
name: transcription factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_yeast
subset: gosubset_prok
synonym: "TF binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0008135
name: translation factor activity, RNA binding
namespace: molecular_function
def: "Functions during translation by interacting selectively and non-covalently with RNA during polypeptide synthesis at the ribosome." [GOC:ai, GOC:vw]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "translation factor activity, nucleic acid binding" BROAD [GOC:mah]
is_a: GO:0003723 ! RNA binding
relationship: part_of GO:0006412 ! translation

[Term]
id: GO:0008137
name: NADH dehydrogenase (ubiquinone) activity
namespace: molecular_function
def: "Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3]
subset: gosubset_prok
synonym: "coenzyme Q reductase activity" EXACT [EC:1.6.5.3]
synonym: "complex 1 dehydrogenase activity" RELATED [EC:1.6.5.3]
synonym: "complex I (electron transport chain) activity" RELATED [EC:1.6.5.3]
synonym: "complex I (mitochondrial electron transport) activity" RELATED [EC:1.6.5.3]
synonym: "complex I (NADH:Q1 oxidoreductase) activity" RELATED [EC:1.6.5.3]
synonym: "dihydronicotinamide adenine dinucleotide-coenzyme Q reductase activity" EXACT [EC:1.6.5.3]
synonym: "DPNH-coenzyme Q reductase activity" EXACT [EC:1.6.5.3]
synonym: "DPNH-ubiquinone reductase activity" EXACT [EC:1.6.5.3]
synonym: "electron transfer complex I activity" RELATED [EC:1.6.5.3]
synonym: "mitochondrial electron transport complex 1 activity" NARROW [EC:1.6.5.3]
synonym: "mitochondrial electron transport complex I activity" NARROW [EC:1.6.5.3]
synonym: "NADH coenzyme Q1 reductase activity" EXACT [EC:1.6.5.3]
synonym: "NADH-coenzyme Q oxidoreductase activity" EXACT [EC:1.6.5.3]
synonym: "NADH-coenzyme Q reductase activity" EXACT [EC:1.6.5.3]
synonym: "NADH-CoQ oxidoreductase activity" EXACT [EC:1.6.5.3]
synonym: "NADH-CoQ reductase activity" EXACT [EC:1.6.5.3]
synonym: "NADH-Q6 oxidoreductase activity" EXACT [EC:1.6.5.3]
synonym: "NADH-ubiquinone oxidoreductase activity" EXACT [EC:1.6.5.3]
synonym: "NADH-ubiquinone reductase activity" EXACT [EC:1.6.5.3]
synonym: "NADH-ubiquinone-1 reductase activity" EXACT [EC:1.6.5.3]
synonym: "NADH:ubiquinone oxidoreductase activity" EXACT [EC:1.6.5.3]
synonym: "NADH:ubiquinone oxidoreductase complex activity" RELATED [EC:1.6.5.3]
synonym: "reduced nicotinamide adenine dinucleotide-coenzyme Q reductase activity" EXACT [EC:1.6.5.3]
synonym: "type 1 dehydrogenase activity" RELATED [EC:1.6.5.3]
synonym: "ubiquinone reductase activity" EXACT []
xref: EC:1.6.5.3
xref: MetaCyc:NADH-DEHYDROG-A-RXN
xref: MetaCyc:RXN0-5330
xref: Reactome:REACT_102400 "NADH enters the respiratory chain at Complex I, Gallus gallus"
xref: Reactome:REACT_33391 "NADH enters the respiratory chain at Complex I, Rattus norvegicus"
xref: Reactome:REACT_6310 "NADH enters the respiratory chain at Complex I, Homo sapiens"
xref: Reactome:REACT_81770 "NADH enters the respiratory chain at Complex I, Canis familiaris"
xref: Reactome:REACT_81943 "NADH enters the respiratory chain at Complex I, Mus musculus"
xref: Reactome:REACT_84378 "NADH enters the respiratory chain at Complex I, Bos taurus"
xref: Reactome:REACT_86959 "NADH enters the respiratory chain at Complex I, Danio rerio"
xref: Reactome:REACT_96903 "NADH enters the respiratory chain at Complex I, Sus scrofa"
xref: Reactome:REACT_98202 "NADH enters the respiratory chain at Complex I, Drosophila melanogaster"
xref: RHEA:23155
is_a: GO:0050136 ! NADH dehydrogenase (quinone) activity

[Term]
id: GO:0008138
name: protein tyrosine/serine/threonine phosphatase activity
namespace: molecular_function
def: "Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]
subset: gosubset_prok
synonym: "dual-specificity protein phosphatase" BROAD []
xref: EC:3.1.3.-
is_a: GO:0004721 ! phosphoprotein phosphatase activity

[Term]
id: GO:0008139
name: nuclear localization sequence binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus." [GOC:ai]
synonym: "NLS binding" EXACT []
synonym: "nuclear localisation sequence binding" EXACT [GOC:mah]
synonym: "nuclear localization signal binding" EXACT []
is_a: GO:0005048 ! signal sequence binding

[Term]
id: GO:0008140
name: cAMP response element binding protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a cAMP response element binding protein (a CREB protein)." [GOC:mah]
synonym: "3',5' cAMP response element binding protein binding" EXACT []
synonym: "3',5'-cAMP response element binding protein binding" EXACT []
synonym: "adenosine 3',5'-cyclophosphate response element binding protein binding" EXACT []
synonym: "CBP" RELATED [GOC:bf]
synonym: "CREB binding" EXACT []
synonym: "cyclic AMP response element binding protein binding" EXACT []
is_a: GO:0008134 ! transcription factor binding

[Term]
id: GO:0008141
name: obsolete puparial glue (sensu Diptera)
namespace: molecular_function
def: "OBSOLETE. A glue which attaches the pupae to the substrate during metamorphosis, as in, but not restricted to, the true flies (Diptera, ncbi_taxonomy_id:7147)." [PMID:825230]
comment: This term was made obsolete because it represents a gene product and not a molecular function.
synonym: "puparial glue (sensu Diptera)" EXACT []
is_obsolete: true
consider: GO:0005198
consider: GO:0007594

[Term]
id: GO:0008142
name: oxysterol binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with oxysterol, an oxidized form of cholesterol." [http://www.onelook.com/]
is_a: GO:0032934 ! sterol binding

[Term]
id: GO:0008143
name: poly(A) binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA." [GOC:jl]
synonym: "poly(A) binding, within an RNA molecule" EXACT []
synonym: "poly(rA) binding" EXACT [GOC:mah]
synonym: "poly-A binding" EXACT [GOC:mah]
synonym: "polyadenylate binding" EXACT [GOC:mah]
is_a: GO:0070717 ! poly-purine tract binding

[Term]
id: GO:0008144
name: drug binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease." [GOC:jl, ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0008145
name: phenylalkylamine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with phenylalkylamine or any of its derivatives." [GOC:jl]
is_a: GO:0008144 ! drug binding
is_a: GO:0043176 ! amine binding

[Term]
id: GO:0008146
name: sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [EC:2.8.2, GOC:curators]
subset: goslim_chembl
subset: gosubset_prok
synonym: "sulphotransferase activity" EXACT []
xref: EC:2.8.2
xref: Reactome:REACT_104339 "lithocholate + PAPS => lithocholate sulfate + PAP, Xenopus tropicalis"
xref: Reactome:REACT_104527 "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP, Bos taurus"
xref: Reactome:REACT_113711 "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP, Danio rerio"
xref: Reactome:REACT_29304 "lithocholate + PAPS => lithocholate sulfate + PAP, Mus musculus"
xref: Reactome:REACT_29933 "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP, Mus musculus"
xref: Reactome:REACT_6770 "lithocholate + PAPS => lithocholate sulfate + PAP, Homo sapiens"
xref: Reactome:REACT_6814 "taurolithocholate + PAPS => taurolithocholate sulfate + PAP, Homo sapiens"
xref: Reactome:REACT_6925 "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP, Homo sapiens"
xref: Reactome:REACT_77351 "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP, Rattus norvegicus"
xref: Reactome:REACT_79428 "lithocholate + PAPS => lithocholate sulfate + PAP, Bos taurus"
xref: Reactome:REACT_81801 "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP, Canis familiaris"
xref: Reactome:REACT_82640 "taurolithocholate + PAPS => taurolithocholate sulfate + PAP, Bos taurus"
xref: Reactome:REACT_87216 "taurolithocholate + PAPS => taurolithocholate sulfate + PAP, Mus musculus"
xref: Reactome:REACT_89499 "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP, Xenopus tropicalis"
xref: Reactome:REACT_90640 "taurolithocholate + PAPS => taurolithocholate sulfate + PAP, Rattus norvegicus"
xref: Reactome:REACT_96373 "lithocholate + PAPS => lithocholate sulfate + PAP, Rattus norvegicus"
xref: Reactome:REACT_98832 "taurolithocholate + PAPS => taurolithocholate sulfate + PAP, Xenopus tropicalis"
is_a: GO:0016782 ! transferase activity, transferring sulfur-containing groups

[Term]
id: GO:0008147
name: structural constituent of bone
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of bone." [GOC:mah]
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0008148
name: obsolete negative transcription elongation factor activity
namespace: molecular_function
def: "OBSOLETE. Any activity that decreases the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation." [GOC:mah]
comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
synonym: "negative transcription elongation factor activity" EXACT []
is_obsolete: true
consider: GO:0032785

[Term]
id: GO:0008149
name: obsolete para-aminobenzoic acid (PABA) synthase
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai, MetaCyc:PABASYN-CPLX]
comment: This term was made obsolete because it refers to two different functions, a glutamine amidotransferase that functions as an aminodeoxychorismate synthase [itself composed of two enzymatic activities, a glutaminase and a chorismate aminase (this latter is sometimes referred to as the aminodeoxychorismate synthase)] and a 4-amino-4-deoxychorismate aromatase (4-amino-4-deoxychorismate lyase). Note that the name 'para-amino benzoate synthase' was initially given to the 'aminodeoxychorismate synthase' activity before the additional lyase activity was discovered.
synonym: "para-aminobenzoic acid (PABA) synthase" EXACT []
is_obsolete: true
consider: GO:0008696
consider: GO:0046820

[Term]
id: GO:0008150
name: biological_process
namespace: biological_process
alt_id: GO:0000004
alt_id: GO:0007582
def: "Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end." [GOC:go_curators, GOC:isa_complete]
comment: Note that, in addition to forming the root of the biological process ontology, this term is recommended for use for the annotation of gene products whose biological process is unknown. Note that when this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this.
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "biological process" EXACT []
synonym: "physiological process" EXACT []
xref: Wikipedia:Biological_process

[Term]
id: GO:0008152
name: metabolic process
namespace: biological_process
def: "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
comment: Note that metabolic processes do not include single functions or processes such as protein-protein interactions, protein-nucleic acids, nor receptor-ligand interactions.
subset: gocheck_do_not_manually_annotate
subset: goslim_chembl
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "metabolic process resulting in cell growth" NARROW []
synonym: "metabolism" EXACT []
synonym: "metabolism resulting in cell growth" NARROW []
xref: Wikipedia:Metabolism
is_a: GO:0008150 ! biological_process
disjoint_from: GO:0044848 ! biological phase

[Term]
id: GO:0008153
name: para-aminobenzoic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of para-aminobenzoic acid, an intermediate in the synthesis of folic acid, a compound which some organisms, e.g. prokaryotes, eukaryotic microbes, and plants, can synthesize de novo. Others, notably mammals, cannot. In yeast, it is present as a factor in the B complex of vitamins." [ISBN:0198506732, PMID:11377864, PMID:11960743]
subset: gosubset_prok
synonym: "4-aminobenzoic acid biosynthesis" EXACT []
synonym: "4-aminobenzoic acid biosynthetic process" EXACT []
synonym: "p-aminobenzoic acid biosynthesis" EXACT []
synonym: "p-aminobenzoic acid biosynthetic process" EXACT []
synonym: "PABA biosynthesis" EXACT []
synonym: "PABA biosynthetic process" EXACT []
synonym: "para-aminobenzoic acid anabolism" EXACT []
synonym: "para-aminobenzoic acid biosynthesis" EXACT []
synonym: "para-aminobenzoic acid formation" EXACT []
synonym: "para-aminobenzoic acid synthesis" EXACT []
synonym: "vitamin Bx biosynthesis" EXACT []
synonym: "vitamin Bx biosynthetic process" EXACT []
is_a: GO:0009073 ! aromatic amino acid family biosynthetic process
is_a: GO:0046482 ! para-aminobenzoic acid metabolic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process

[Term]
id: GO:0008154
name: actin polymerization or depolymerization
namespace: biological_process
def: "Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament." [GOC:mah]
is_a: GO:0007015 ! actin filament organization

[Term]
id: GO:0008155
name: obsolete larval behavior (sensu Drosophila)
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because there is no clear difference between the sensu Drosophila term and the generic term.
synonym: "larval behavior (sensu Drosophila)" EXACT []
is_obsolete: true
replaced_by: GO:0030537

[Term]
id: GO:0008156
name: negative regulation of DNA replication
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication." [GOC:go_curators]
subset: gosubset_prok
synonym: "DNA replication inhibitor" RELATED []
synonym: "down regulation of DNA replication" EXACT []
synonym: "down-regulation of DNA replication" EXACT []
synonym: "downregulation of DNA replication" EXACT []
synonym: "inhibition of DNA replication" NARROW []
is_a: GO:0006275 ! regulation of DNA replication
is_a: GO:0051053 ! negative regulation of DNA metabolic process
is_a: GO:2000113 ! negative regulation of cellular macromolecule biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006260 ! DNA replication
relationship: negatively_regulates GO:0006260 ! DNA replication

[Term]
id: GO:0008157
name: protein phosphatase 1 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the enzyme protein phosphatase 1." [GOC:jl]
is_a: GO:0019903 ! protein phosphatase binding

[Term]
id: GO:0008158
name: hedgehog receptor activity
namespace: molecular_function
def: "Combining with a member of the hedgehog protein family and transmitting the signal across the membrane to initiate a change in cell activity." [GOC:bf, GOC:go_curators, PMID:9278137]
synonym: "patched activity" EXACT []
is_a: GO:0004888 ! transmembrane signaling receptor activity
relationship: has_part GO:0097108 ! hedgehog family protein binding

[Term]
id: GO:0008159
name: obsolete positive transcription elongation factor activity
namespace: molecular_function
def: "OBSOLETE. Any activity that increases the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation." [GOC:mah]
comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
synonym: "positive transcription elongation factor activity" EXACT []
is_obsolete: true
consider: GO:0032786

[Term]
id: GO:0008160
name: protein tyrosine phosphatase activator activity
namespace: molecular_function
def: "Increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a tyrosyl phenolic group of a protein." [GOC:ai, ISBN:0198506732]
is_a: GO:0072542 ! protein phosphatase activator activity
relationship: positively_regulates GO:0004725 ! protein tyrosine phosphatase activity

[Term]
id: GO:0008161
name: obsolete carbamate resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process.
synonym: "carbamate resistance" EXACT []
is_obsolete: true
replaced_by: GO:0046681

[Term]
id: GO:0008162
name: obsolete cyclodiene resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process.
synonym: "cyclodiene resistance" EXACT []
is_obsolete: true
replaced_by: GO:0046682

[Term]
id: GO:0008163
name: obsolete DDT resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process.
synonym: "DDT resistance" EXACT []
is_obsolete: true
replaced_by: GO:0046680

[Term]
id: GO:0008164
name: obsolete organophosphorus resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process.
synonym: "organophosphorus resistance" EXACT []
is_obsolete: true
replaced_by: GO:0046683

[Term]
id: GO:0008165
name: obsolete pyrethroid resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process.
synonym: "pyrethroid resistance" EXACT []
is_obsolete: true
replaced_by: GO:0046684

[Term]
id: GO:0008166
name: obsolete viral replication
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it covers multiple processes and is now covered by more specific terms.
synonym: "viral replication" EXACT []
is_obsolete: true
consider: GO:0019079

[Term]
id: GO:0008167
name: obsolete sigma virus replication
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
synonym: "sigma virus replication" EXACT []
is_obsolete: true
replaced_by: GO:0019079

[Term]
id: GO:0008168
name: methyltransferase activity
namespace: molecular_function
alt_id: GO:0004480
def: "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_yeast
subset: gosubset_prok
synonym: "methylase" BROAD []
xref: EC:2.1.1
xref: Reactome:REACT_100745 "Methylation of 3,4-dihydroxypheylacetic acid to homovanillic acid, Bos taurus"
xref: Reactome:REACT_100863 "methylation of Dopamine to form 3-Methoxytyramine, Taeniopygia guttata"
xref: Reactome:REACT_100884 "methylation of Dopamine to form 3-Methoxytyramine, Xenopus tropicalis"
xref: Reactome:REACT_103958 "methylation of Dopamine to form 3-Methoxytyramine, Rattus norvegicus"
xref: Reactome:REACT_104757 "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine, Danio rerio"
xref: Reactome:REACT_105478 "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine, Bos taurus"
xref: Reactome:REACT_105909 "Methylation of 3,4-dihydroxypheylacetic acid to homovanillic acid, Xenopus tropicalis"
xref: Reactome:REACT_106465 "Methylation of 3,4-dihydroxypheylacetic acid to homovanillic acid, Sus scrofa"
xref: Reactome:REACT_107676 "Methylation of 3,4-dihydroxypheylacetic acid to homovanillic acid, Schizosaccharomyces pombe"
xref: Reactome:REACT_15531 "methylation of Dopamine to form 3-Methoxytyramine, Homo sapiens"
xref: Reactome:REACT_15553 "Methylation of 3,4-dihydroxypheylacetic acid to homovanillic acid, Homo sapiens"
xref: Reactome:REACT_2094 "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine, Homo sapiens"
xref: Reactome:REACT_29020 "methylation of Dopamine to form 3-Methoxytyramine, Bos taurus"
xref: Reactome:REACT_29098 "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine, Canis familiaris"
xref: Reactome:REACT_33644 "Methylation of 3,4-dihydroxypheylacetic acid to homovanillic acid, Mycobacterium tuberculosis"
xref: Reactome:REACT_33779 "methylation of Dopamine to form 3-Methoxytyramine, Mycobacterium tuberculosis"
xref: Reactome:REACT_73401 "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine, Rattus norvegicus"
xref: Reactome:REACT_77286 "methylation of Dopamine to form 3-Methoxytyramine, Canis familiaris"
xref: Reactome:REACT_78774 "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine, Mus musculus"
xref: Reactome:REACT_79799 "Methylation of 3,4-dihydroxypheylacetic acid to homovanillic acid, Mus musculus"
xref: Reactome:REACT_83214 "Methylation of 3,4-dihydroxypheylacetic acid to homovanillic acid, Gallus gallus"
xref: Reactome:REACT_84525 "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine, Taeniopygia guttata"
xref: Reactome:REACT_84974 "methylation of Dopamine to form 3-Methoxytyramine, Sus scrofa"
xref: Reactome:REACT_86817 "methylation of Dopamine to form 3-Methoxytyramine, Schizosaccharomyces pombe"
xref: Reactome:REACT_86905 "Methylation of 3,4-dihydroxypheylacetic acid to homovanillic acid, Rattus norvegicus"
xref: Reactome:REACT_87169 "Methylation of 3,4-dihydroxypheylacetic acid to homovanillic acid, Taeniopygia guttata"
xref: Reactome:REACT_93379 "methylation of Dopamine to form 3-Methoxytyramine, Gallus gallus"
xref: Reactome:REACT_93809 "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine, Xenopus tropicalis"
xref: Reactome:REACT_94274 "Methylation of 3,4-dihydroxypheylacetic acid to homovanillic acid, Canis familiaris"
xref: Reactome:REACT_96444 "methylation of Dopamine to form 3-Methoxytyramine, Mus musculus"
xref: Reactome:REACT_99316 "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine, Gallus gallus"
is_a: GO:0016741 ! transferase activity, transferring one-carbon groups
relationship: part_of GO:0032259 ! methylation

[Term]
id: GO:0008169
name: C-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group to the carbon atom of an acceptor molecule." [GOC:ai]
subset: gosubset_prok
xref: EC:2.1.1.-
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0008170
name: N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule." [GOC:ai]
subset: gosubset_prok
xref: EC:2.1.1.-
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0008171
name: O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule." [GOC:ai]
subset: gosubset_prok
xref: EC:2.1.1.-
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0008172
name: S-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group to the sulfur atom of an acceptor molecule." [GOC:ai]
subset: gosubset_prok
xref: EC:2.1.1.-
xref: Reactome:REACT_100679 "Methylation of N-acetyl-5-HT to form melatonin, Mycobacterium tuberculosis"
xref: Reactome:REACT_108292 "Methylation of N-acetyl-5-HT to form melatonin, Gallus gallus"
xref: Reactome:REACT_109382 "Methylation of N-acetyl-5-HT to form melatonin, Rattus norvegicus"
xref: Reactome:REACT_109916 "Methylation of N-acetyl-5-HT to form melatonin, Dictyostelium discoideum"
xref: Reactome:REACT_15383 "Methylation of N-acetyl-5-HT to form melatonin, Homo sapiens"
xref: Reactome:REACT_78486 "Methylation of N-acetyl-5-HT to form melatonin, Taeniopygia guttata"
xref: Reactome:REACT_83527 "Methylation of N-acetyl-5-HT to form melatonin, Danio rerio"
xref: Reactome:REACT_86396 "Methylation of N-acetyl-5-HT to form melatonin, Arabidopsis thaliana"
xref: Reactome:REACT_87589 "Methylation of N-acetyl-5-HT to form melatonin, Canis familiaris"
xref: Reactome:REACT_89643 "Methylation of N-acetyl-5-HT to form melatonin, Oryza sativa"
xref: Reactome:REACT_96228 "Methylation of N-acetyl-5-HT to form melatonin, Xenopus tropicalis"
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0008173
name: RNA methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule." [GOC:mah]
comment: Note that the methyl donor is usually S-adenosyl-L-methionine, but there is at least one exception (see GO:0030698).
subset: gosubset_prok
xref: EC:2.1.1.-
xref: Reactome:REACT_10002 "snRNA Cap hypermethylation, Homo sapiens"
xref: Reactome:REACT_102135 "snRNA Cap hypermethylation, Danio rerio"
xref: Reactome:REACT_108169 "snRNA Cap hypermethylation, Rattus norvegicus"
xref: Reactome:REACT_29381 "snRNA Cap hypermethylation, Gallus gallus"
xref: Reactome:REACT_54083 "snRNA Cap hypermethylation, Bos taurus"
xref: Reactome:REACT_79845 "snRNA Cap hypermethylation, Xenopus tropicalis"
xref: Reactome:REACT_82745 "snRNA Cap hypermethylation, Drosophila melanogaster"
xref: Reactome:REACT_88858 "snRNA Cap hypermethylation, Canis familiaris"
xref: Reactome:REACT_95210 "snRNA Cap hypermethylation, Mus musculus"
is_a: GO:0008168 ! methyltransferase activity
relationship: part_of GO:0001510 ! RNA methylation

[Term]
id: GO:0008174
name: mRNA methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an mRNA molecule." [GOC:mah]
subset: gosubset_prok
xref: EC:2.1.1.-
is_a: GO:0008173 ! RNA methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
relationship: part_of GO:0080009 ! mRNA methylation

[Term]
id: GO:0008175
name: tRNA methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule." [GOC:mah]
subset: gosubset_prok
xref: EC:2.1.1.-
is_a: GO:0008173 ! RNA methyltransferase activity
relationship: part_of GO:0030488 ! tRNA methylation

[Term]
id: GO:0008176
name: tRNA (guanine-N7-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N7-methylguanine." [EC:2.1.1.33]
subset: gosubset_prok
synonym: "7-methylguanine transfer ribonucleate methylase activity" EXACT [EC:2.1.1.33]
synonym: "N7-methylguanine methylase activity" EXACT [EC:2.1.1.33]
synonym: "S-adenosyl-L-methionine:tRNA (guanine-7-N-)-methyltransferase activity" EXACT [EC:2.1.1.33]
synonym: "S-adenosyl-L-methionine:tRNA (guanine-N7-)-methyltransferase activity" EXACT [EC:2.1.1.33]
synonym: "transfer ribonucleate guanine 7-methyltransferase activity" EXACT [EC:2.1.1.33]
synonym: "tRNA guanine 7-methyltransferase activity" EXACT [EC:2.1.1.33]
xref: EC:2.1.1.33
xref: MetaCyc:TRNA-GUANINE-N7--METHYLTRANSFERASE-RXN
is_a: GO:0016423 ! tRNA (guanine) methyltransferase activity
relationship: part_of GO:0036265 ! RNA (guanine-N7)-methylation

[Term]
id: GO:0008177
name: succinate dehydrogenase (ubiquinone) activity
namespace: molecular_function
alt_id: GO:0019737
def: "Catalysis of the reaction: succinate + ubiquinone = fumarate + ubiquinol." [EC:1.3.5.1, RHEA:13716]
subset: gosubset_prok
synonym: "complex II" RELATED [EC:1.3.5.1]
synonym: "fumarate reductase complex (i.e. FRD, involved in anaerobic respiration, repressed in aerobic respiration)" RELATED [EC:1.3.5.1]
synonym: "menaquinol: fumarate oxidoreductase activity" EXACT [EC:1.3.5.1]
synonym: "quinol:fumarate oxidoreductase activity" EXACT []
synonym: "succinate dehydrogenase complex (i. e. SDH, involved in aerobic respiration, repressed in anaerobic respiration)" RELATED [EC:1.3.5.1]
synonym: "succinate:ubiquinone oxidoreductase activity" EXACT [EC:1.3.5.1]
synonym: "succinic dehydrogenase activity" BROAD [EC:1.3.5.1]
xref: EC:1.3.5.1
xref: KEGG:R02164
xref: MetaCyc:SUCCINATE-DEHYDROGENASE-UBIQUINONE-RXN
xref: Reactome:REACT_103505 "Transfer of electrons through the succinate dehydrogenase complex, Danio rerio"
xref: Reactome:REACT_105603 "Succinate <=> Fumarate (with FAD redox reaction on enzyme), Canis familiaris"
xref: Reactome:REACT_115740 "succinate + FAD <=> fumarate + FADH2, Gallus gallus"
xref: Reactome:REACT_115746 "fumarate + FADH2 <=> succinate + FAD, Gallus gallus"
xref: Reactome:REACT_1667 "Succinate <=> Fumarate (with FAD redox reaction on enzyme), Homo sapiens"
xref: Reactome:REACT_29121 "Succinate <=> Fumarate (with FAD redox reaction on enzyme), Bos taurus"
xref: Reactome:REACT_31722 "Succinate <=> Fumarate (with FAD redox reaction on enzyme), Taeniopygia guttata"
xref: Reactome:REACT_32775 "Succinate <=> Fumarate (with FAD redox reaction on enzyme), Dictyostelium discoideum"
xref: Reactome:REACT_61395 "Succinate <=> Fumarate (with FAD redox reaction on enzyme), Schizosaccharomyces pombe"
xref: Reactome:REACT_6292 "Transfer of electrons through the bovine succinate dehydrogenase complex, Bos taurus"
xref: Reactome:REACT_6360 "Transfer of electrons through the succinate dehydrogenase complex, Homo sapiens"
xref: Reactome:REACT_79375 "Succinate <=> Fumarate (with FAD redox reaction on enzyme), Rattus norvegicus"
xref: Reactome:REACT_80248 "Transfer of electrons through the succinate dehydrogenase complex, Schizosaccharomyces pombe"
xref: Reactome:REACT_83108 "Transfer of electrons through the succinate dehydrogenase complex, Caenorhabditis elegans"
xref: Reactome:REACT_84074 "Succinate <=> Fumarate (with FAD redox reaction on enzyme), Mus musculus"
xref: Reactome:REACT_84221 "Transfer of electrons through the succinate dehydrogenase complex, Canis familiaris"
xref: Reactome:REACT_85717 "Succinate <=> Fumarate (with FAD redox reaction on enzyme), Gallus gallus"
xref: Reactome:REACT_88528 "Succinate <=> Fumarate (with FAD redox reaction on enzyme), Saccharomyces cerevisiae"
xref: Reactome:REACT_88562 "Transfer of electrons through the succinate dehydrogenase complex, Saccharomyces cerevisiae"
xref: Reactome:REACT_88611 "Transfer of electrons through the succinate dehydrogenase complex, Drosophila melanogaster"
xref: Reactome:REACT_89112 "Succinate <=> Fumarate (with FAD redox reaction on enzyme), Danio rerio"
xref: Reactome:REACT_90176 "Transfer of electrons through the succinate dehydrogenase complex, Taeniopygia guttata"
xref: Reactome:REACT_92395 "Transfer of electrons through the succinate dehydrogenase complex, Mus musculus"
xref: Reactome:REACT_92514 "Transfer of electrons through the succinate dehydrogenase complex, Xenopus tropicalis"
xref: Reactome:REACT_97027 "Transfer of electrons through the succinate dehydrogenase complex, Rattus norvegicus"
xref: Reactome:REACT_97164 "Succinate <=> Fumarate (with FAD redox reaction on enzyme), Caenorhabditis elegans"
xref: Reactome:REACT_98347 "Transfer of electrons through the succinate dehydrogenase complex, Gallus gallus"
xref: Reactome:REACT_99061 "Succinate <=> Fumarate (with FAD redox reaction on enzyme), Drosophila melanogaster"
xref: Reactome:REACT_99184 "Succinate <=> Fumarate (with FAD redox reaction on enzyme), Xenopus tropicalis"
xref: Reactome:REACT_99727 "Transfer of electrons through the succinate dehydrogenase complex, Dictyostelium discoideum"
xref: RHEA:13716
is_a: GO:0000104 ! succinate dehydrogenase activity
is_a: GO:0016635 ! oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor

[Term]
id: GO:0008179
name: adenylate cyclase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the enzyme adenylate cyclase." [GOC:jl]
synonym: "adenylyl cyclase binding" EXACT []
xref: Reactome:REACT_101410 "Galpha-olf:GTP binds to adenylate cyclase and activates it, Xenopus tropicalis"
xref: Reactome:REACT_106393 "Galpha-olf:GTP binds to adenylate cyclase and activates it, Caenorhabditis elegans"
xref: Reactome:REACT_108102 "Galpha-olf:GTP binds to adenylate cyclase and activates it, Taeniopygia guttata"
xref: Reactome:REACT_15385 "Galpha-olf:GTP binds to adenylate cyclase and activates it, Homo sapiens"
xref: Reactome:REACT_28771 "Galpha-olf:GTP binds to adenylate cyclase and activates it, Gallus gallus"
xref: Reactome:REACT_30807 "Galpha-olf:GTP binds to adenylate cyclase and activates it, Mus musculus"
xref: Reactome:REACT_79377 "Galpha-olf:GTP binds to adenylate cyclase and activates it, Bos taurus"
xref: Reactome:REACT_79434 "Galpha-olf:GTP binds to adenylate cyclase and activates it, Danio rerio"
xref: Reactome:REACT_80878 "Galpha-olf:GTP binds to adenylate cyclase and activates it, Drosophila melanogaster"
xref: Reactome:REACT_86589 "Galpha-olf:GTP binds to adenylate cyclase and activates it, Rattus norvegicus"
xref: Reactome:REACT_98781 "Galpha-olf:GTP binds to adenylate cyclase and activates it, Canis familiaris"
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0008180
name: COP9 signalosome
namespace: cellular_component
def: "A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome." [PMID:11019806, PMID:12186635, PMID:14570571]
synonym: "COP9 complex" EXACT [GOC:krc]
synonym: "CSN" EXACT []
synonym: "signalosome" BROAD [GOC:krc]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0008181
name: obsolete tumor suppressor
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it does not represent a true biological function, rather a pathology that occurs when a particular gene product is inactivated in some way.
synonym: "tumor suppressor" EXACT []
is_obsolete: true
consider: GO:0051726

[Term]
id: GO:0008184
name: glycogen phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycogen + phosphate = maltodextrin + alpha-D-glucose 1-phosphate." [EC:2.4.1.1, MetaCyc:GLYCOPHOSPHORYL-RXN]
subset: gosubset_prok
xref: MetaCyc:GLYCOPHOSPHORYL-RXN
xref: Reactome:REACT_100822 "poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL], Oryza sativa"
xref: Reactome:REACT_101928 "glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL], Xenopus tropicalis"
xref: Reactome:REACT_105334 "glycogen-glycogenin-1 + n orthophosphate => limit dextrin-glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB], Canis familiaris"
xref: Reactome:REACT_105439 "glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL], Canis familiaris"
xref: Reactome:REACT_105618 "poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL], Canis familiaris"
xref: Reactome:REACT_105814 "poly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate => glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB], Bos taurus"
xref: Reactome:REACT_107581 "glycogen-glycogenin-1 + n orthophosphate => limit dextrin-glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB], Oryza sativa"
xref: Reactome:REACT_107584 "glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL], Saccharomyces cerevisiae"
xref: Reactome:REACT_107912 "poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL], Taeniopygia guttata"
xref: Reactome:REACT_112008 "poly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate => glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB], Caenorhabditis elegans"
xref: Reactome:REACT_112419 "poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL], Danio rerio"
xref: Reactome:REACT_112518 "glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL], Arabidopsis thaliana"
xref: Reactome:REACT_112595 "glycogen-glycogenin-1 + n orthophosphate => limit dextrin-glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB], Arabidopsis thaliana"
xref: Reactome:REACT_112994 "poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL], Caenorhabditis elegans"
xref: Reactome:REACT_113339 "poly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate => glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB], Arabidopsis thaliana"
xref: Reactome:REACT_113449 "poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL], Arabidopsis thaliana"
xref: Reactome:REACT_113915 "glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL], Caenorhabditis elegans"
xref: Reactome:REACT_114127 "glycogen-glycogenin-1 + n orthophosphate => limit dextrin-glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB], Caenorhabditis elegans"
xref: Reactome:REACT_114709 "glycogen-glycogenin-1 + n orthophosphate => limit dextrin-glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB], Xenopus tropicalis"
xref: Reactome:REACT_114725 "poly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate => glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB], Xenopus tropicalis"
xref: Reactome:REACT_115476 "glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL], Danio rerio"
xref: Reactome:REACT_1348 "glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL], Homo sapiens"
xref: Reactome:REACT_1670 "glycogen-glycogenin-1 + n orthophosphate => limit dextrin-glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB], Homo sapiens"
xref: Reactome:REACT_21296 "poly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate => glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB], Homo sapiens"
xref: Reactome:REACT_21313 "poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL], Homo sapiens"
xref: Reactome:REACT_28714 "glycogen-glycogenin-1 + n orthophosphate => limit dextrin-glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB], Mus musculus"
xref: Reactome:REACT_81684 "glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL], Taeniopygia guttata"
xref: Reactome:REACT_82267 "poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL], Xenopus tropicalis"
xref: Reactome:REACT_82552 "glycogen-glycogenin-1 + n orthophosphate => limit dextrin-glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB], Rattus norvegicus"
xref: Reactome:REACT_82895 "poly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate => glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB], Rattus norvegicus"
xref: Reactome:REACT_83376 "poly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate => glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB], Saccharomyces cerevisiae"
xref: Reactome:REACT_85158 "poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL], Bos taurus"
xref: Reactome:REACT_85829 "poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL], Gallus gallus"
xref: Reactome:REACT_89721 "poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL], Saccharomyces cerevisiae"
xref: Reactome:REACT_90286 "poly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate => glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB], Oryza sativa"
xref: Reactome:REACT_91496 "glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL], Bos taurus"
xref: Reactome:REACT_92019 "glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL], Gallus gallus"
xref: Reactome:REACT_92183 "poly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate => glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB], Canis familiaris"
xref: Reactome:REACT_93113 "glycogen-glycogenin-1 + n orthophosphate => limit dextrin-glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB], Bos taurus"
xref: Reactome:REACT_93778 "glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL], Oryza sativa"
xref: Reactome:REACT_94984 "glycogen-glycogenin-1 + n orthophosphate => limit dextrin-glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB], Sus scrofa"
xref: Reactome:REACT_95199 "poly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate => glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB], Sus scrofa"
xref: Reactome:REACT_95607 "glycogen-glycogenin-1 + n orthophosphate => limit dextrin-glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB], Danio rerio"
xref: Reactome:REACT_97919 "poly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate => glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB], Danio rerio"
xref: Reactome:REACT_98230 "glycogen-glycogenin-1 + n orthophosphate => limit dextrin-glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB], Saccharomyces cerevisiae"
xref: Reactome:REACT_99449 "poly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate => glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB], Mus musculus"
is_a: GO:0004645 ! phosphorylase activity

[Term]
id: GO:0008186
name: RNA-dependent ATPase activity
namespace: molecular_function
alt_id: GO:0004010
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of RNA, and it drives another reaction." [EC:3.6.1.3, GOC:jl]
subset: gosubset_prok
synonym: "RNA-dependent adenosinetriphosphatase activity" EXACT []
is_a: GO:0042623 ! ATPase activity, coupled

[Term]
id: GO:0008187
name: poly-pyrimidine tract binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any stretch of pyrimidines (cytosine or uracil) in an RNA molecule." [GOC:jl]
is_a: GO:0003727 ! single-stranded RNA binding

[Term]
id: GO:0008188
name: neuropeptide receptor activity
namespace: molecular_function
def: "Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]
is_a: GO:0008528 ! G-protein coupled peptide receptor activity
relationship: has_part GO:0042923 ! neuropeptide binding
relationship: part_of GO:0007218 ! neuropeptide signaling pathway

[Term]
id: GO:0008189
name: obsolete apoptosis inhibitor activity
namespace: molecular_function
def: "OBSOLETE. The function held by products which directly block any step in the process of apoptosis." [GOC:hb]
comment: This term was made obsolete because it represents involvement in a biological process.
synonym: "apoptosis inhibitor activity" EXACT []
is_obsolete: true
replaced_by: GO:0043066

[Term]
id: GO:0008190
name: eukaryotic initiation factor 4E binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with eukaryotic initiation factor 4E, a polypeptide factor involved in the initiation of ribosome-mediated translation." [ISBN:0198506732]
synonym: "eIF4E binding" EXACT []
is_a: GO:0031369 ! translation initiation factor binding

[Term]
id: GO:0008191
name: metalloendopeptidase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity." [GOC:ai]
subset: gosubset_prok
synonym: "metalloprotease inhibitor" NARROW []
synonym: "metalloproteinase inhibitor" NARROW []
is_a: GO:0004866 ! endopeptidase inhibitor activity
relationship: negatively_regulates GO:0004222 ! metalloendopeptidase activity

[Term]
id: GO:0008192
name: RNA guanylyltransferase activity
namespace: molecular_function
def: "Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of an RNA molecule." [GOC:mah]
xref: EC:2.7.7.-
is_a: GO:0070568 ! guanylyltransferase activity

[Term]
id: GO:0008193
name: tRNA guanylyltransferase activity
namespace: molecular_function
def: "Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of a tRNA molecule; observed for His tRNAs." [PMID:1660461]
xref: EC:2.7.7.-
is_a: GO:0008192 ! RNA guanylyltransferase activity

[Term]
id: GO:0008194
name: UDP-glycosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule." [InterPro:IPR004224, PMID:11846783]
subset: gosubset_prok
xref: Reactome:REACT_103000 "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP, Bos taurus"
xref: Reactome:REACT_107220 "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP, Taeniopygia guttata"
xref: Reactome:REACT_108286 "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP, Oryza sativa"
xref: Reactome:REACT_108804 "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP, Mus musculus"
xref: Reactome:REACT_110628 "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP, Arabidopsis thaliana"
xref: Reactome:REACT_1240 "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP, Homo sapiens"
xref: Reactome:REACT_32928 "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP, Dictyostelium discoideum"
xref: Reactome:REACT_34344 "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP, Danio rerio"
xref: Reactome:REACT_80577 "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP, Xenopus tropicalis"
xref: Reactome:REACT_84444 "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP, Rattus norvegicus"
xref: Reactome:REACT_85640 "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP, Gallus gallus"
xref: Reactome:REACT_89402 "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP, Canis familiaris"
xref: Reactome:REACT_92152 "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP, Sus scrofa"
xref: Reactome:REACT_95814 "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP, Schizosaccharomyces pombe"
xref: Reactome:REACT_97586 "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP, Drosophila melanogaster"
is_a: GO:0016757 ! transferase activity, transferring glycosyl groups

[Term]
id: GO:0008195
name: phosphatidate phosphatase activity
namespace: molecular_function
alt_id: GO:0004606
def: "Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate." [EC:3.1.3.4, GOC:pr]
synonym: "3-sn-phosphatidate phosphohydrolase activity" EXACT [EC:3.1.3.4]
synonym: "acid phosphatidyl phosphatase activity" EXACT [EC:3.1.3.4]
synonym: "phosphatic acid phosphatase activity" EXACT [EC:3.1.3.4]
synonym: "phosphatic acid phosphohydrolase activity" EXACT [EC:3.1.3.4]
synonym: "phosphatidate phosphohydrolase activity" EXACT []
synonym: "phosphatidic acid phosphatase activity" EXACT [EC:3.1.3.4]
xref: EC:3.1.3.4
xref: MetaCyc:PHOSPHATIDATE-PHOSPHATASE-RXN
xref: Reactome:REACT_101150 "Dephosphorylation of phosphoPFKFB1 by PP2A complex, Dictyostelium discoideum"
xref: Reactome:REACT_101234 "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate, Mus musculus"
xref: Reactome:REACT_103609 "Dephosphorylation of phosphoPFKFB1 by PP2A complex, Bos taurus"
xref: Reactome:REACT_104543 "Dephosphorylation of pChREBP (Ser 196) by PP2A, Taeniopygia guttata"
xref: Reactome:REACT_105218 "Dephosphorylation of AKT by PP2A, Canis familiaris"
xref: Reactome:REACT_105489 "Dephosphorylation of pChREBP (Thr 666) by PP2A, Canis familiaris"
xref: Reactome:REACT_108097 "Dephosphorylation of pChREBP (Ser 196) by PP2A, Bos taurus"
xref: Reactome:REACT_109086 "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate, Bos taurus"
xref: Reactome:REACT_109607 "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_112281 "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate, Drosophila melanogaster"
xref: Reactome:REACT_114 "Dephosphorylation of prChREBP (Ser 568) by rPP2A complex, Rattus norvegicus"
xref: Reactome:REACT_1347 "Dephosphorylation of phosphoPFKFB1 by PP2A complex, Homo sapiens"
xref: Reactome:REACT_1416 "Dephosphorylation of pChREBP (Ser 196) by PP2A, Homo sapiens"
xref: Reactome:REACT_1564 "Dephosphorylation of prChREBP (Ser 196) by rPP2A, Rattus norvegicus"
xref: Reactome:REACT_19209 "Dephosphorylation of AKT by PP2A, Homo sapiens"
xref: Reactome:REACT_1936 "Dephosphorylation of PF2K-Pase by rPP2A complex, Rattus norvegicus"
xref: Reactome:REACT_31407 "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate, Taeniopygia guttata"
xref: Reactome:REACT_33461 "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate, Canis familiaris"
xref: Reactome:REACT_33769 "Dephosphorylation of AKT by PP2A, Rattus norvegicus"
xref: Reactome:REACT_34099 "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_34335 "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_34408 "Dephosphorylation of pChREBP (Thr 666) by PP2A, Taeniopygia guttata"
xref: Reactome:REACT_382 "Dephosphorylation of pChREBP (Thr 666) by PP2A, Homo sapiens"
xref: Reactome:REACT_395 "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate, Homo sapiens"
xref: Reactome:REACT_454 "Dephosphorylation of prChREBP (Thr 666) by rPP2A, Rattus norvegicus"
xref: Reactome:REACT_76989 "Dephosphorylation of pChREBP (Thr 666) by PP2A, Mus musculus"
xref: Reactome:REACT_77567 "Dephosphorylation of pChREBP (Thr 666) by PP2A, Bos taurus"
xref: Reactome:REACT_78126 "Dephosphorylation of phosphoPFKFB1 by PP2A complex, Canis familiaris"
xref: Reactome:REACT_78248 "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate, Sus scrofa"
xref: Reactome:REACT_814 "Dephosphorylation of pChREBP (Ser 568) by PP2A, Homo sapiens"
xref: Reactome:REACT_81736 "Dephosphorylation of AKT by PP2A, Taeniopygia guttata"
xref: Reactome:REACT_82747 "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate, Rattus norvegicus"
xref: Reactome:REACT_82832 "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate, Xenopus tropicalis"
xref: Reactome:REACT_83218 "Dephosphorylation of pChREBP (Ser 196) by PP2A, Canis familiaris"
xref: Reactome:REACT_84255 "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate, Oryza sativa"
xref: Reactome:REACT_86836 "Dephosphorylation of phosphoPFKFB1 by PP2A complex, Drosophila melanogaster"
xref: Reactome:REACT_90354 "Dephosphorylation of AKT by PP2A, Mus musculus"
xref: Reactome:REACT_92569 "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate, Danio rerio"
xref: Reactome:REACT_93763 "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate, Plasmodium falciparum"
xref: Reactome:REACT_95010 "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate, Gallus gallus"
xref: Reactome:REACT_95054 "Dephosphorylation of pChREBP (Ser 196) by PP2A, Mus musculus"
xref: Reactome:REACT_95082 "Dephosphorylation of AKT by PP2A, Drosophila melanogaster"
xref: Reactome:REACT_96400 "Dephosphorylation of AKT by PP2A, Xenopus tropicalis"
xref: Reactome:REACT_96981 "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate, Arabidopsis thaliana"
xref: Reactome:REACT_97045 "Dephosphorylation of phosphoPFKFB1 by PP2A complex, Mus musculus"
xref: Reactome:REACT_98095 "Dephosphorylation of AKT by PP2A, Bos taurus"
xref: Reactome:REACT_98462 "Dephosphorylation of phosphoPFKFB1 by PP2A complex, Taeniopygia guttata"
xref: RHEA:27432
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0008196
name: vitellogenin receptor activity
namespace: molecular_function
def: "Receiving vitellogenin, and delivering vitellogenin into the cell via endocytosis." [GOC:bf, PMID:12429745]
is_a: GO:0038024 ! cargo receptor activity

[Term]
id: GO:0008197
name: obsolete yolk protein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it does not represent a molecular function.
synonym: "yolk protein" EXACT []
is_obsolete: true
consider: GO:0005198
consider: GO:0045735

[Term]
id: GO:0008198
name: ferrous iron binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with ferrous iron, Fe(II)." [GOC:ai]
subset: gosubset_prok
is_a: GO:0005506 ! iron ion binding

[Term]
id: GO:0008199
name: ferric iron binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with ferric iron, Fe(III)." [GOC:ai]
subset: gosubset_prok
is_a: GO:0005506 ! iron ion binding

[Term]
id: GO:0008200
name: ion channel inhibitor activity
namespace: molecular_function
def: "Stops, prevents, or reduces the activity of an ion channel." [GOC:mah]
subset: gosubset_prok
is_a: GO:0016248 ! channel inhibitor activity
relationship: negatively_regulates GO:0005216 ! ion channel activity

[Term]
id: GO:0008201
name: heparin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:jl, ISBN:0198506732]
synonym: "heparan sulfate binding" RELATED []
is_a: GO:0005539 ! glycosaminoglycan binding
is_a: GO:0043168 ! anion binding
is_a: GO:1901681 ! sulfur compound binding

[Term]
id: GO:0008202
name: steroid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [ISBN:0198547684]
subset: gosubset_prok
synonym: "steroid metabolism" EXACT []
xref: Reactome:REACT_100535 "Metabolism of steroid hormones and vitamins A and D, Schizosaccharomyces pombe"
xref: Reactome:REACT_104514 "Metabolism of steroid hormones and vitamins A and D, Bos taurus"
xref: Reactome:REACT_104993 "Metabolism of steroid hormones and vitamins A and D, Saccharomyces cerevisiae"
xref: Reactome:REACT_105831 "Metabolism of steroid hormones and vitamins A and D, Dictyostelium discoideum"
xref: Reactome:REACT_108650 "Metabolism of steroid hormones and vitamins A and D, Gallus gallus"
xref: Reactome:REACT_109307 "Metabolism of steroid hormones and vitamins A and D, Mycobacterium tuberculosis"
xref: Reactome:REACT_109504 "Metabolism of steroid hormones and vitamins A and D, Caenorhabditis elegans"
xref: Reactome:REACT_110283 "Metabolism of steroid hormones and vitamins A and D, Danio rerio"
xref: Reactome:REACT_11057 "Metabolism of steroid hormones and vitamins A and D, Homo sapiens"
xref: Reactome:REACT_32683 "Metabolism of steroid hormones and vitamins A and D, Drosophila melanogaster"
xref: Reactome:REACT_34426 "Metabolism of steroid hormones and vitamins A and D, Arabidopsis thaliana"
xref: Reactome:REACT_77930 "Metabolism of steroid hormones and vitamins A and D, Canis familiaris"
xref: Reactome:REACT_81781 "Metabolism of steroid hormones and vitamins A and D, Escherichia coli"
xref: Reactome:REACT_85390 "Metabolism of steroid hormones and vitamins A and D, Oryza sativa"
xref: Reactome:REACT_86063 "Metabolism of steroid hormones and vitamins A and D, Taeniopygia guttata"
xref: Reactome:REACT_86862 "Metabolism of steroid hormones and vitamins A and D, Mus musculus"
xref: Reactome:REACT_90075 "Metabolism of steroid hormones and vitamins A and D, Rattus norvegicus"
xref: Reactome:REACT_93239 "Metabolism of steroid hormones and vitamins A and D, Sus scrofa"
xref: Reactome:REACT_96786 "Metabolism of steroid hormones and vitamins A and D, Xenopus tropicalis"
xref: Reactome:REACT_97355 "Metabolism of steroid hormones and vitamins A and D, Plasmodium falciparum"
xref: Wikipedia:Steroid_metabolism
is_a: GO:0006629 ! lipid metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process

[Term]
id: GO:0008203
name: cholesterol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues." [ISBN:0198506732]
subset: gosubset_prok
synonym: "cholesterol metabolism" EXACT []
is_a: GO:0016125 ! sterol metabolic process
is_a: GO:1902652 ! secondary alcohol metabolic process

[Term]
id: GO:0008204
name: ergosterol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds. It is the most important of the D provitamins and is converted to vitamin D2 on irradiation with UV light." [ISBN:0198506732]
subset: gosubset_prok
synonym: "ergosterol metabolism" EXACT []
is_a: GO:0016125 ! sterol metabolic process
is_a: GO:0016128 ! phytosteroid metabolic process
is_a: GO:0044107 ! cellular alcohol metabolic process
is_a: GO:0044255 ! cellular lipid metabolic process
is_a: GO:1902652 ! secondary alcohol metabolic process

[Term]
id: GO:0008205
name: ecdysone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects. It is the inactive prohormone of the moulting hormone ecdysterone and may have intrinsic hormonal activity at other stages of insect development." [ISBN:0198506732]
synonym: "ecdysone metabolism" EXACT []
is_a: GO:0016125 ! sterol metabolic process
is_a: GO:0045455 ! ecdysteroid metabolic process
is_a: GO:1902652 ! secondary alcohol metabolic process

[Term]
id: GO:0008206
name: bile acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving bile acids, any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine." [GOC:go_curators]
synonym: "bile acid metabolism" EXACT []
xref: Reactome:REACT_105895 "Bile acid and bile salt metabolism, Escherichia coli"
xref: Reactome:REACT_107037 "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine, Canis familiaris"
xref: Reactome:REACT_108027 "Bile acid and bile salt metabolism, Canis familiaris"
xref: Reactome:REACT_11040 "Bile acid and bile salt metabolism, Homo sapiens"
xref: Reactome:REACT_113960 "Bile acid and bile salt metabolism, Plasmodium falciparum"
xref: Reactome:REACT_115499 "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine, Gallus gallus"
xref: Reactome:REACT_28546 "Bile acid and bile salt metabolism, Sus scrofa"
xref: Reactome:REACT_63021 "Bile acid and bile salt metabolism, Gallus gallus"
xref: Reactome:REACT_78457 "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine, Rattus norvegicus"
xref: Reactome:REACT_79218 "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine, Taeniopygia guttata"
xref: Reactome:REACT_81169 "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine, Bos taurus"
xref: Reactome:REACT_81692 "Bile acid and bile salt metabolism, Arabidopsis thaliana"
xref: Reactome:REACT_84189 "Bile acid and bile salt metabolism, Saccharomyces cerevisiae"
xref: Reactome:REACT_85308 "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine, Xenopus tropicalis"
xref: Reactome:REACT_85920 "Bile acid and bile salt metabolism, Caenorhabditis elegans"
xref: Reactome:REACT_86691 "Bile acid and bile salt metabolism, Mycobacterium tuberculosis"
xref: Reactome:REACT_88051 "Bile acid and bile salt metabolism, Danio rerio"
xref: Reactome:REACT_88359 "Bile acid and bile salt metabolism, Mus musculus"
xref: Reactome:REACT_91224 "Bile acid and bile salt metabolism, Rattus norvegicus"
xref: Reactome:REACT_92109 "Bile acid and bile salt metabolism, Schizosaccharomyces pombe"
xref: Reactome:REACT_92844 "Bile acid and bile salt metabolism, Bos taurus"
xref: Reactome:REACT_93323 "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine, Mus musculus"
xref: Reactome:REACT_93509 "Bile acid and bile salt metabolism, Taeniopygia guttata"
xref: Reactome:REACT_94447 "Bile acid and bile salt metabolism, Drosophila melanogaster"
xref: Reactome:REACT_94869 "Bile acid and bile salt metabolism, Dictyostelium discoideum"
xref: Reactome:REACT_96936 "Bile acid and bile salt metabolism, Oryza sativa"
xref: Reactome:REACT_98204 "Bile acid and bile salt metabolism, Xenopus tropicalis"
xref: Reactome:REACT_99705 "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine, Sus scrofa"
xref: Reactome:REACT_9991 "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine, Homo sapiens"
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process

[Term]
id: GO:0008207
name: C21-steroid hormone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones." [GOC:ai]
synonym: "C21-steroid hormone metabolism" EXACT []
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:0034754 ! cellular hormone metabolic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0008208
name: C21-steroid hormone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones." [GOC:ai]
synonym: "C21-steroid hormone breakdown" EXACT []
synonym: "C21-steroid hormone catabolism" EXACT []
synonym: "C21-steroid hormone degradation" EXACT []
is_a: GO:0006706 ! steroid catabolic process
is_a: GO:0008207 ! C21-steroid hormone metabolic process
is_a: GO:0042447 ! hormone catabolic process

[Term]
id: GO:0008209
name: androgen metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics." [ISBN:0198506732]
synonym: "androgen metabolism" EXACT []
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:0034754 ! cellular hormone metabolic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0008210
name: estrogen metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants." [ISBN:0198506732]
subset: gosubset_prok
synonym: "estrogen metabolism" EXACT []
synonym: "oestrogen metabolic process" EXACT []
synonym: "oestrogen metabolism" EXACT []
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:0034754 ! cellular hormone metabolic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0008211
name: glucocorticoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects." [ISBN:0198506732]
synonym: "glucocorticoid metabolism" EXACT []
synonym: "glucocorticosteroid metabolic process" EXACT []
synonym: "glucocorticosteroid metabolism" EXACT []
is_a: GO:0008202 ! steroid metabolic process

[Term]
id: GO:0008212
name: mineralocorticoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Mineralocorticoids act primarily on water and electrolyte balance." [ISBN:0198506732]
synonym: "mineralocorticoid metabolism" EXACT []
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:0034754 ! cellular hormone metabolic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0008213
name: protein alkylation
namespace: biological_process
def: "The addition of an alkyl group to a protein amino acid. An alkyl group is any group derived from an alkane by removal of one hydrogen atom." [GOC:ma]
subset: goslim_yeast
subset: gosubset_prok
synonym: "protein amino acid alkylation" EXACT [GOC:bf]
is_a: GO:0006464 ! cellular protein modification process

[Term]
id: GO:0008214
name: protein dealkylation
namespace: biological_process
def: "The removal of an alkyl group from a protein amino acid. An alkyl group is any group derived from an alkane by removal of one hydrogen atom." [GOC:ai]
subset: gosubset_prok
synonym: "protein amino acid dealkylation" EXACT [GOC:bf]
is_a: GO:0006464 ! cellular protein modification process

[Term]
id: GO:0008215
name: spermine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication." [CHEBI:15746, GOC:curators]
subset: gosubset_prok
synonym: "spermine metabolism" EXACT []
xref: Reactome:REACT_100725 "Spermine is oxidized to spermidine, Xenopus tropicalis"
xref: Reactome:REACT_102996 "Spermine is oxidized to spermidine, Danio rerio"
xref: Reactome:REACT_104101 "Spermine is oxidized to spermidine, Taeniopygia guttata"
xref: Reactome:REACT_114114 "Spermine is oxidized to spermidine, Caenorhabditis elegans"
xref: Reactome:REACT_114150 "Spermine is oxidized to spermidine, Drosophila melanogaster"
xref: Reactome:REACT_2194 "Spermine is oxidized to spermidine, Homo sapiens"
xref: Reactome:REACT_33308 "Spermine is oxidized to spermidine, Canis familiaris"
xref: Reactome:REACT_34337 "Spermine is oxidized to spermidine, Sus scrofa"
xref: Reactome:REACT_77844 "Spermine is oxidized to spermidine, Gallus gallus"
xref: Reactome:REACT_79419 "Spermine is oxidized to spermidine, Mus musculus"
xref: Reactome:REACT_84703 "Spermine is oxidized to spermidine, Saccharomyces cerevisiae"
xref: Reactome:REACT_85293 "Spermine is oxidized to spermidine, Bos taurus"
xref: Reactome:REACT_92172 "Spermine is oxidized to spermidine, Oryza sativa"
xref: Reactome:REACT_93069 "Spermine is oxidized to spermidine, Arabidopsis thaliana"
xref: Reactome:REACT_94623 "Spermine is oxidized to spermidine, Rattus norvegicus"
is_a: GO:0006595 ! polyamine metabolic process
is_a: GO:0097164 ! ammonium ion metabolic process

[Term]
id: GO:0008216
name: spermidine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:ai]
subset: gosubset_prok
synonym: "spermidine metabolism" EXACT []
is_a: GO:0006595 ! polyamine metabolic process
is_a: GO:0097164 ! ammonium ion metabolic process

[Term]
id: GO:0008217
name: regulation of blood pressure
namespace: biological_process
def: "Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure." [GOC:dph, GOC:mtg_cardio, ISBN:0721643949]
synonym: "blood pressure homeostasis" RELATED []
synonym: "blood pressure regulation" EXACT []
synonym: "control of blood pressure" RELATED []
xref: Wikipedia:Blood_pressure#Regulation
is_a: GO:0065008 ! regulation of biological quality
relationship: part_of GO:0008015 ! blood circulation

[Term]
id: GO:0008218
name: bioluminescence
namespace: biological_process
def: "The production of light by certain enzyme-catalyzed reactions in cells." [ISBN:0198506732]
subset: goslim_chembl
subset: gosubset_prok
xref: Wikipedia:Bioluminescence
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0008219
name: cell death
namespace: biological_process
def: "Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538)." [GOC:mah, GOC:mtg_apoptosis, PMID:25236395]
comment: This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide) show that cell death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Also, if experimental data suggest that a gene product influences cell death indirectly, rather than being involved in the death process directly, consider annotating to a 'regulation' term.
subset: goslim_chembl
subset: goslim_generic
subset: goslim_plant
subset: gosubset_prok
synonym: "accidental cell death" RELATED []
synonym: "necrosis" RELATED []
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0008220
name: obsolete necrosis
namespace: biological_process
def: "OBSOLETE. The processes that cause necrosis, the death of tissues, in another organism." [GOC:ma]
comment: This term was made obsolete because the term has been used in the literature by groups in different areas of biology with a number of varying explicit and implicit definitions, and more appropriate terms were created.
synonym: "necrosis" EXACT []
is_obsolete: true
consider: GO:0001906
consider: GO:0008219
consider: GO:0012501
consider: GO:0019835
consider: GO:0070265

[Term]
id: GO:0008222
name: obsolete tumor antigen
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity.
synonym: "tumor antigen" EXACT []
is_obsolete: true

[Term]
id: GO:0008224
name: obsolete Gram-positive antibacterial peptide activity
namespace: molecular_function
def: "OBSOLETE. Inhibits the growth of, or directly kills, Gram-positive bacterial cells." [GOC:go_curators]
comment: This term was made obsolete because it describes involvement in a process and not a function.
synonym: "Gram-positive antibacterial peptide activity" EXACT []
is_obsolete: true
consider: GO:0050830

[Term]
id: GO:0008225
name: obsolete Gram-negative antibacterial peptide activity
namespace: molecular_function
def: "OBSOLETE. Inhibits the growth of, or directly kills, Gram-negative bacterial cells." [GOC:go_curators]
comment: This term was made obsolete because it describes involvement in a process and not a function.
synonym: "Gram-negative antibacterial peptide activity" EXACT []
is_obsolete: true
consider: GO:0050829

[Term]
id: GO:0008226
name: tyramine receptor activity
namespace: molecular_function
def: "Combining with the biogenic amine tyramine to initiate a change in cell activity. Tyramine is a sympathomimetic amine derived from tyrosine with an action resembling that of epinephrine." [http://www.onelook.com/]
is_a: GO:0008227 ! G-protein coupled amine receptor activity

[Term]
id: GO:0008227
name: G-protein coupled amine receptor activity
namespace: molecular_function
def: "Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph]
subset: gosubset_prok
synonym: "amine receptor activity, G-protein coupled" EXACT [GOC:bf]
synonym: "biogenic amine receptor" NARROW []
is_a: GO:0004930 ! G-protein coupled receptor activity

[Term]
id: GO:0008228
name: opsonization
namespace: biological_process
def: "The process in which a microorganism (or other particulate material) is rendered more susceptible to phagocytosis by coating with an opsonin, a blood serum protein such as a complement component or antibody." [GOC:add, GOC:mah, ISBN:0198506732, ISBN:068340007X, ISBN:0781735149]
xref: Wikipedia:Opsonin
is_a: GO:0002252 ! immune effector process
relationship: part_of GO:0006909 ! phagocytosis

[Term]
id: GO:0008229
name: obsolete opsonin activity
namespace: molecular_function
def: "OBSOLETE. Binds to microorganisms or other particulate material (for example, foreign erythrocytes) to increase the susceptibility of the latter to phagocytosis." [ISBN:0198506732]
comment: This term was made obsolete because it represents a class of gene products.
synonym: "opsonin activity" EXACT []
is_obsolete: true
consider: GO:0003823

[Term]
id: GO:0008230
name: ecdysone receptor holocomplex
namespace: cellular_component
def: "A heterodimeric complex containing the products of the insect genes Ecdysone receptor (EcR) and ultraspiracle (usp). Binding of ecdysone promotes association between the two subunits, and the receptor complex then initiates molting and metamorphosis by binding DNA and regulating the transcription of target genes." [GOC:bf, PMID:14592980]
is_a: GO:0043235 ! receptor complex
is_a: GO:0090575 ! RNA polymerase II transcription factor complex

[Term]
id: GO:0008231
name: repressor ecdysone receptor complex
namespace: cellular_component
def: "A protein complex consisting of a heterodimer of Ecdysone receptor (EcR) and ultraspiracle (usp) plus an associated corepressor such as SMRTER, which represses transcription of target genes." [PMID:10488333]
synonym: "repressor ecdysone receptor holocomplex" RELATED []
is_a: GO:0008230 ! ecdysone receptor holocomplex

[Term]
id: GO:0008232
name: activator ecdysone receptor complex
namespace: cellular_component
def: "A protein complex consisting of a heterodimer of Ecdysone receptor (EcR) and ultraspiracle (usp) bound to the ligand ecdysone, which activates transcription of target genes." [PMID:10488333]
synonym: "activator ecdysone receptor holocomplex" RELATED []
is_a: GO:0008230 ! ecdysone receptor holocomplex

[Term]
id: GO:0008233
name: peptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
synonym: "hydrolase, acting on peptide bonds" EXACT []
synonym: "peptide hydrolase activity" EXACT []
synonym: "protease activity" NARROW []
synonym: "proteinase activity" NARROW []
xref: EC:3.4
xref: Reactome:REACT_106748 "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6, Rattus norvegicus"
xref: Reactome:REACT_110349 "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6, Mus musculus"
xref: Reactome:REACT_13710 "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6, Homo sapiens"
xref: Reactome:REACT_19284 "Proteolytic processing of Slit, Homo sapiens"
xref: Reactome:REACT_93020 "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6, Bos taurus"
xref: Reactome:REACT_99630 "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6, Gallus gallus"
is_a: GO:0016787 ! hydrolase activity
relationship: part_of GO:0006508 ! proteolysis

[Term]
id: GO:0008234
name: cysteine-type peptidase activity
namespace: molecular_function
alt_id: GO:0004220
def: "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
subset: gosubset_prok
synonym: "cysteine protease activity" NARROW []
synonym: "thiol protease activity" NARROW []
xref: EC:3.4.-.-
is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides

[Term]
id: GO:0008235
name: metalloexopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#EXOPEPTIDASE]
subset: gosubset_prok
xref: Reactome:REACT_27316 "cleavage of L-cysteine from carrier protein, Mycobacterium tuberculosis"
is_a: GO:0008237 ! metallopeptidase activity
is_a: GO:0008238 ! exopeptidase activity

[Term]
id: GO:0008236
name: serine-type peptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
subset: gosubset_prok
synonym: "serine protease activity" NARROW []
xref: Reactome:REACT_116162 "pro-HD5 is cleaved by trypsin, Homo sapiens"
is_a: GO:0017171 ! serine hydrolase activity
is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides

[Term]
id: GO:0008237
name: metallopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
subset: gosubset_prok
synonym: "metalloprotease activity" NARROW [GOC:mah]
synonym: "metalloproteinase activity" NARROW [GOC:mah]
xref: Reactome:REACT_100129 "Notch 4-ligand complex is cleaved to produce NEXT4, Sus scrofa"
xref: Reactome:REACT_100372 "Notch 1-ligand complex is cleaved to produce NEXT1, Gallus gallus"
xref: Reactome:REACT_100593 "Cleavage of ATF6-alpha by S2P, Drosophila melanogaster"
xref: Reactome:REACT_100677 "alpha-secretase cleaves the p75NTR extracellular domain, Rattus norvegicus"
xref: Reactome:REACT_100694 "Notch 1-ligand complex is cleaved to produce NEXT1, Xenopus tropicalis"
xref: Reactome:REACT_1011 "Notch 4-ligand complex is cleaved to produce NEXT4, Homo sapiens"
xref: Reactome:REACT_101972 "Notch 1-ligand complex is cleaved to produce NEXT1, Taeniopygia guttata"
xref: Reactome:REACT_102999 "Notch 1-ligand complex is cleaved to produce NEXT1, Drosophila melanogaster"
xref: Reactome:REACT_103085 "Cleavage of ATF6-alpha by S2P, Sus scrofa"
xref: Reactome:REACT_104327 "Notch 2-ligand complex is cleaved to produce NEXT2, Gallus gallus"
xref: Reactome:REACT_104368 "Cleavage of ATF6-alpha by S2P, Taeniopygia guttata"
xref: Reactome:REACT_107504 "alpha-secretase cleaves the p75NTR extracellular domain, Bos taurus"
xref: Reactome:REACT_109423 "Cleavage of ATF6-alpha by S2P, Bos taurus"
xref: Reactome:REACT_109532 "Notch 1-ligand complex is cleaved to produce NEXT1, Danio rerio"
xref: Reactome:REACT_114094 "Notch 3-ligand complex is cleaved to produce NEXT3, Drosophila melanogaster"
xref: Reactome:REACT_115138 "Notch 4-ligand complex is cleaved to produce NEXT4, Xenopus tropicalis"
xref: Reactome:REACT_13658 "alpha-secretase cleaves the p75NTR extracellular domain, Homo sapiens"
xref: Reactome:REACT_1552 "Notch 3-ligand complex is cleaved to produce NEXT3, Homo sapiens"
xref: Reactome:REACT_18387 "Cleavage of ATF6-alpha by S2P, Homo sapiens"
xref: Reactome:REACT_267 "Notch 2-ligand complex is cleaved to produce NEXT2, Homo sapiens"
xref: Reactome:REACT_28662 "Notch 1-ligand complex is cleaved to produce NEXT1, Bos taurus"
xref: Reactome:REACT_29018 "Notch 4-ligand complex is cleaved to produce NEXT4, Rattus norvegicus"
xref: Reactome:REACT_30292 "Notch 3-ligand complex is cleaved to produce NEXT3, Danio rerio"
xref: Reactome:REACT_30924 "Notch 2-ligand complex is cleaved to produce NEXT2, Drosophila melanogaster"
xref: Reactome:REACT_33366 "Notch 4-ligand complex is cleaved to produce NEXT4, Canis familiaris"
xref: Reactome:REACT_33539 "alpha-secretase cleaves the p75NTR extracellular domain, Gallus gallus"
xref: Reactome:REACT_33732 "Notch 4-ligand complex is cleaved to produce NEXT4, Mus musculus"
xref: Reactome:REACT_33852 "Notch 3-ligand complex is cleaved to produce NEXT3, Rattus norvegicus"
xref: Reactome:REACT_33929 "Cleavage of ATF6-alpha by S2P, Gallus gallus"
xref: Reactome:REACT_410 "Notch 1-ligand complex is cleaved to produce NEXT1, Homo sapiens"
xref: Reactome:REACT_77236 "Notch 4-ligand complex is cleaved to produce NEXT4, Bos taurus"
xref: Reactome:REACT_78816 "Notch 3-ligand complex is cleaved to produce NEXT3, Bos taurus"
xref: Reactome:REACT_79691 "alpha-secretase cleaves the p75NTR extracellular domain, Canis familiaris"
xref: Reactome:REACT_79817 "Notch 2-ligand complex is cleaved to produce NEXT2, Mus musculus"
xref: Reactome:REACT_81981 "Notch 2-ligand complex is cleaved to produce NEXT2, Bos taurus"
xref: Reactome:REACT_83198 "Notch 1-ligand complex is cleaved to produce NEXT1, Rattus norvegicus"
xref: Reactome:REACT_83310 "Notch 2-ligand complex is cleaved to produce NEXT2, Sus scrofa"
xref: Reactome:REACT_83988 "Notch 2-ligand complex is cleaved to produce NEXT2, Xenopus tropicalis"
xref: Reactome:REACT_89528 "Cleavage of ATF6-alpha by S2P, Danio rerio"
xref: Reactome:REACT_89928 "alpha-secretase cleaves the p75NTR extracellular domain, Sus scrofa"
xref: Reactome:REACT_91564 "Cleavage of ATF6-alpha by S2P, Rattus norvegicus"
xref: Reactome:REACT_92210 "alpha-secretase cleaves the p75NTR extracellular domain, Danio rerio"
xref: Reactome:REACT_92309 "Notch 3-ligand complex is cleaved to produce NEXT3, Xenopus tropicalis"
xref: Reactome:REACT_92841 "alpha-secretase cleaves the p75NTR extracellular domain, Xenopus tropicalis"
xref: Reactome:REACT_93042 "Cleavage of ATF6-alpha by S2P, Mus musculus"
xref: Reactome:REACT_94705 "Notch 2-ligand complex is cleaved to produce NEXT2, Danio rerio"
xref: Reactome:REACT_95173 "Notch 3-ligand complex is cleaved to produce NEXT3, Canis familiaris"
xref: Reactome:REACT_95565 "Notch 2-ligand complex is cleaved to produce NEXT2, Rattus norvegicus"
xref: Reactome:REACT_96136 "Notch 1-ligand complex is cleaved to produce NEXT1, Canis familiaris"
xref: Reactome:REACT_96651 "Cleavage of ATF6-alpha by S2P, Caenorhabditis elegans"
xref: Reactome:REACT_96860 "Notch 2-ligand complex is cleaved to produce NEXT2, Canis familiaris"
xref: Reactome:REACT_96983 "Cleavage of ATF6-alpha by S2P, Xenopus tropicalis"
xref: Reactome:REACT_97764 "alpha-secretase cleaves the p75NTR extracellular domain, Mus musculus"
xref: Reactome:REACT_98127 "Notch 1-ligand complex is cleaved to produce NEXT1, Mus musculus"
xref: Reactome:REACT_98562 "Cleavage of ATF6-alpha by S2P, Canis familiaris"
xref: Reactome:REACT_99318 "Notch 3-ligand complex is cleaved to produce NEXT3, Mus musculus"
is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides

[Term]
id: GO:0008238
name: exopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain, in a reaction that requires a free N-terminal amino group, C-terminal carboxyl group or both." [http://merops.sanger.ac.uk/about/glossary.htm#EXOPEPTIDASE]
subset: gosubset_prok
synonym: "exoprotease activity" NARROW []
is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides

[Term]
id: GO:0008239
name: dipeptidyl-peptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb]
subset: gosubset_prok
is_a: GO:0004177 ! aminopeptidase activity

[Term]
id: GO:0008240
name: tripeptidyl-peptidase activity
namespace: molecular_function
def: "Catalysis of the release of an N-terminal tripeptide from a polypeptide." [GOC:mah]
xref: EC:3.4.14.-
xref: MetaCyc:3.4.14.10-RXN
xref: MetaCyc:3.4.14.9-RXN
is_a: GO:0008236 ! serine-type peptidase activity
is_a: GO:0008238 ! exopeptidase activity

[Term]
id: GO:0008241
name: peptidyl-dipeptidase activity
namespace: molecular_function
def: "Catalysis of the release of C-terminal dipeptides from a polypeptide chain." [GOC:mb]
subset: gosubset_prok
xref: EC:3.4.15
is_a: GO:0008238 ! exopeptidase activity

[Term]
id: GO:0008242
name: omega peptidase activity
namespace: molecular_function
def: "Catalysis of the removal of terminal peptide residues that are substituted, cyclized or linked by isopeptide bonds (peptide linkages other than those of alpha-carboxyl to alpha-amino groups)." [EC:3.4.19.-]
subset: gosubset_prok
synonym: "peptidase activity, acting on peptides containing modified amino acids" RELATED []
xref: EC:3.4.19
is_a: GO:0008238 ! exopeptidase activity

[Term]
id: GO:0008243
name: obsolete plasminogen activator activity
namespace: molecular_function
alt_id: GO:0004296
alt_id: GO:0004297
def: "OBSOLETE. Catalysis of the specific cleavage of an Arg-Val bond in plasminogen to form plasmin." [EC:3.4.21.68, EC:3.4.21.73]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "abbokinase activity" EXACT [EC:3.4.21.68]
synonym: "cellular plasminogen activator activity" NARROW [EC:3.4.21.-]
synonym: "double-chain urokinase-type plasminogen activator" RELATED [EC:3.4.21.68]
synonym: "plasminogen activator activity" EXACT []
synonym: "plasminogen activator, tissue-type" RELATED [EC:3.4.21.68]
synonym: "t-PA" RELATED [EC:3.4.21.68]
synonym: "t-plasminogen activator activity" NARROW []
synonym: "tissue plasminogen activator activity" NARROW [EC:3.4.21.-]
synonym: "tissue-type plasminogen activator activity" RELATED [EC:3.4.21.-]
synonym: "tPA activity" NARROW [EC:3.4.21.-]
synonym: "two-chain urokinase-type plasminogen activator" RELATED [EC:3.4.21.68]
synonym: "u-PA" RELATED [EC:3.4.21.68]
synonym: "u-plasminogen activator activity" NARROW []
synonym: "uPA" RELATED [EC:3.4.21.68]
synonym: "urinary esterase A" RELATED [EC:3.4.21.68]
synonym: "urinary plasminogen activator activity" NARROW [EC:3.4.21.-]
synonym: "urokinase activity" RELATED [EC:3.4.21.-]
synonym: "urokinase plasminogen activator" RELATED [EC:3.4.21.68]
synonym: "urokinase-type plasminogen activator" RELATED [EC:3.4.21.68]
xref: EC:3.4.21.68
xref: EC:3.4.21.73
xref: MetaCyc:3.4.21.68-RXN
xref: MetaCyc:3.4.21.73-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0008245
name: obsolete lysosomal membrane hydrogen-transporting ATPase
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because more specific terms were created.
synonym: "lysosomal membrane hydrogen-transporting ATPase" EXACT []
synonym: "V-ATPase" RELATED []
is_obsolete: true
consider: GO:0046611

[Term]
id: GO:0008246
name: obsolete electron transfer flavoprotein
namespace: molecular_function
def: "OBSOLETE. Works in conjunction with acyl-CoA dehydrogenase to catalyze the oxidation of CoA and reduce ubiquinone. Part of the mitochondrial electron transport system." [ISBN:0198506732]
comment: This term was made obsolete because it refers to a class of gene products.
synonym: "electron transfer flavoprotein" EXACT []
synonym: "ETF" EXACT []
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0008247
name: 1-alkyl-2-acetylglycerophosphocholine esterase complex
namespace: cellular_component
def: "An enzyme complex composed of two catalytic alpha subunits, which form a catalytic dimer, and a non-catalytic, regulatory beta subunit; the catalytic dimer may be an alpha1/alpha1 or alpha2/alpha2 homodimer, or an alpha1/alpha2 heterodimer. Modulates the action of platelet-activating factor (PAF)." [GOC:jl, PMID:10542206]
comment: See also the molecular function term '1-alkyl-2-acetylglycerophosphocholine esterase activity ; GO:0003847'.
subset: gosubset_prok
synonym: "2-acetyl-1-alkylglycerophosphocholine esterase complex" EXACT []
synonym: "platelet-activating factor acetylhydrolase complex" EXACT []
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0008248
name: obsolete pre-mRNA splicing factor activity
namespace: molecular_function
def: "OBSOLETE. An activity involved in the removal of an intron from a pre-mRNA." [GOC:jl]
comment: This term was made obsolete because it describes a biological process.
synonym: "pre-mRNA splicing factor activity" EXACT []
is_obsolete: true
consider: GO:0008380

[Term]
id: GO:0008250
name: oligosaccharyltransferase complex
namespace: cellular_component
def: "A protein complex that is found in the endoplasmic reticulum membrane of eukaryotes and transfers lipid-linked oligosaccharide precursor to asparagine residues on nascent proteins. In yeast, the complex includes at least nine different subunits, whereas in mammalian cells at least three different forms of the complex have been detected." [ISBN:0879695595, PMID:15835887]
synonym: "oligosaccharyl transferase complex" EXACT []
synonym: "OST complex" EXACT []
is_a: GO:0044432 ! endoplasmic reticulum part
is_a: GO:0098796 ! membrane protein complex
is_a: GO:1990234 ! transferase complex
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane

[Term]
id: GO:0008251
name: tRNA-specific adenosine deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a tRNA molecule." [GOC:mah, IMG:00700]
subset: gosubset_prok
synonym: "tRNA-adenosine deaminase activity" EXACT []
xref: EC:3.5.4.-
is_a: GO:0004000 ! adenosine deaminase activity

[Term]
id: GO:0008252
name: nucleotidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate." [EC:3.1.3.31]
subset: gosubset_prok
synonym: "acid nucleotidase activity" EXACT [EC:3.1.3.31]
synonym: "deoxyinosine-activated nucleotidase (DIAN)" EXACT [EC:3.1.3.31]
synonym: "deoxyribonucleoside-activated nucleotidase (DAN)" EXACT [EC:3.1.3.31]
synonym: "NSP I" RELATED [EC:3.1.3.31]
synonym: "NSP II" RELATED [EC:3.1.3.31]
synonym: "nucleotide phosphohydrolase activity" EXACT [EC:3.1.3.31]
synonym: "nucleotide-specific phosphatase activity" EXACT [EC:3.1.3.31]
xref: EC:3.1.3.31
xref: MetaCyc:NUCLEOTIDASE-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0008253
name: 5'-nucleotidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate." [EC:3.1.3.5]
subset: gosubset_prok
synonym: "5' nucleotidase activity" EXACT []
synonym: "5'-adenylic phosphatase" NARROW [EC:3.1.3.5]
synonym: "5'-AMP nucleotidase" NARROW [EC:3.1.3.5]
synonym: "5'-AMPase" NARROW [EC:3.1.3.5]
synonym: "5'-mononucleotidase activity" EXACT [EC:3.1.3.5]
synonym: "5'-ribonucleotide phosphohydrolase activity" EXACT [EC:3.1.3.5]
synonym: "adenosine 5'-phosphatase" NARROW [EC:3.1.3.5]
synonym: "adenosine monophosphatase" NARROW [EC:3.1.3.5]
synonym: "AMP phosphatase" NARROW [EC:3.1.3.5]
synonym: "AMP phosphohydrolase" NARROW [EC:3.1.3.5]
synonym: "AMPase" NARROW [EC:3.1.3.5]
synonym: "snake venom 5'-nucleotidase" NARROW [EC:3.1.3.5]
synonym: "thimidine monophosphate nucleotidase" NARROW [EC:3.1.3.5]
synonym: "UMPase" NARROW [EC:3.1.3.5]
synonym: "uridine 5'-nucleotidase" NARROW [EC:3.1.3.5]
xref: EC:3.1.3.5
xref: MetaCyc:5-NUCLEOTID-RXN
xref: Reactome:REACT_100085 "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate [NT5C3], Arabidopsis thaliana"
xref: Reactome:REACT_100316 "(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate [NT5C], Xenopus tropicalis"
xref: Reactome:REACT_100433 "AMP + H2O => adenosine + orthophosphate [NT5C1B], Sus scrofa"
xref: Reactome:REACT_100476 "AMP + H2O => adenosine + orthophosphate [NT5C1B], Canis familiaris"
xref: Reactome:REACT_100571 "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate [NT5C3], Mus musculus"
xref: Reactome:REACT_100848 "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate [NT5C1A], Danio rerio"
xref: Reactome:REACT_101326 "AMP, dAMP, GMP, or IMP + H2O => adenosine, deoxyadenosine, guanosine, or inosine + orthophosphate [NT5E], Staphylococcus aureus N315"
xref: Reactome:REACT_102002 "AMP + H2O => adenosine + orthophosphate [NT5C1B], Danio rerio"
xref: Reactome:REACT_102273 "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate [NT5C1A], Canis familiaris"
xref: Reactome:REACT_102639 "TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C], Bos taurus"
xref: Reactome:REACT_103438 "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate [NT5C3], Canis familiaris"
xref: Reactome:REACT_103911 "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate [NT5C1A], Danio rerio"
xref: Reactome:REACT_104449 "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E], Danio rerio"
xref: Reactome:REACT_104784 "AMP, dAMP, GMP, or IMP + H2O => adenosine, deoxyadenosine, guanosine, or inosine + orthophosphate [NT5E], Rattus norvegicus"
xref: Reactome:REACT_105189 "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate [NT5C1A], Canis familiaris"
xref: Reactome:REACT_105515 "AMP, dAMP, GMP, or IMP + H2O => adenosine, deoxyadenosine, guanosine, or inosine + orthophosphate [NT5E], Xenopus tropicalis"
xref: Reactome:REACT_106553 "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate [NT5C3], Taeniopygia guttata"
xref: Reactome:REACT_107023 "(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate [NT5C], Rattus norvegicus"
xref: Reactome:REACT_107294 "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate [NT5C1A], Bos taurus"
xref: Reactome:REACT_107411 "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate [NT5C2], Arabidopsis thaliana"
xref: Reactome:REACT_107857 "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E], Gallus gallus"
xref: Reactome:REACT_107994 "(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate [NT5C], Sus scrofa"
xref: Reactome:REACT_108023 "AMP + H2O => adenosine + orthophosphate [NT5C1B], Mus musculus"
xref: Reactome:REACT_108205 "(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate [NT5C], Canis familiaris"
xref: Reactome:REACT_108315 "TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C], Rattus norvegicus"
xref: Reactome:REACT_108343 "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate [NT5C3], Oryza sativa"
xref: Reactome:REACT_108781 "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate [NT5C1A], Sus scrofa"
xref: Reactome:REACT_108911 "AMP, dAMP, GMP, or IMP + H2O => adenosine, deoxyadenosine, guanosine, or inosine + orthophosphate [NT5E], Gallus gallus"
xref: Reactome:REACT_108996 "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M], Sus scrofa"
xref: Reactome:REACT_109328 "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate [NT5C3], Danio rerio"
xref: Reactome:REACT_109514 "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate [NT5C3], Bos taurus"
xref: Reactome:REACT_109710 "TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C], Canis familiaris"
xref: Reactome:REACT_110392 "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate [NT5C3], Caenorhabditis elegans"
xref: Reactome:REACT_110453 "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate [NT5C1A], Taeniopygia guttata"
xref: Reactome:REACT_110550 "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate [NT5C2], Taeniopygia guttata"
xref: Reactome:REACT_110853 "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E], Staphylococcus aureus N315"
xref: Reactome:REACT_1172 "TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C], Homo sapiens"
xref: Reactome:REACT_1236 "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E], Homo sapiens"
xref: Reactome:REACT_1336 "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate [NT5C2], Homo sapiens"
xref: Reactome:REACT_1389 "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M], Homo sapiens"
xref: Reactome:REACT_1556 "AMP + H2O => adenosine + orthophosphate [NT5C1B], Homo sapiens"
xref: Reactome:REACT_1972 "(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate [NT5C], Homo sapiens"
xref: Reactome:REACT_2012 "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate [NT5C1A], Homo sapiens"
xref: Reactome:REACT_28292 "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E], Sus scrofa"
xref: Reactome:REACT_28329 "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate [NT5C2], Gallus gallus"
xref: Reactome:REACT_28401 "AMP, dAMP, GMP, or IMP + H2O => adenosine, deoxyadenosine, guanosine, or inosine + orthophosphate [NT5E], Taeniopygia guttata"
xref: Reactome:REACT_30267 "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate [NT5C2], Rattus norvegicus"
xref: Reactome:REACT_31281 "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate [NT5C2], Mus musculus"
xref: Reactome:REACT_33552 "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate [NT5C2], Caenorhabditis elegans"
xref: Reactome:REACT_34655 "AMP + H2O => adenosine + orthophosphate [NT5C1B], Taeniopygia guttata"
xref: Reactome:REACT_358 "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate [NT5C3], Homo sapiens"
xref: Reactome:REACT_61891 "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E], Bos taurus"
xref: Reactome:REACT_76998 "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate [NT5C3], Drosophila melanogaster"
xref: Reactome:REACT_77127 "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate [NT5C2], Dictyostelium discoideum"
xref: Reactome:REACT_77437 "(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate [NT5C], Mus musculus"
xref: Reactome:REACT_78141 "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M], Xenopus tropicalis"
xref: Reactome:REACT_78631 "AMP, dAMP, GMP, or IMP + H2O => adenosine, deoxyadenosine, guanosine, or inosine + orthophosphate [NT5E], Sus scrofa"
xref: Reactome:REACT_78828 "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate [NT5C1A], Mus musculus"
xref: Reactome:REACT_78927 "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate [NT5C2], Xenopus tropicalis"
xref: Reactome:REACT_80098 "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate [NT5C1A], Bos taurus"
xref: Reactome:REACT_80186 "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate [NT5C2], Drosophila melanogaster"
xref: Reactome:REACT_81078 "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate [NT5C1A], Gallus gallus"
xref: Reactome:REACT_81741 "AMP + H2O => adenosine + orthophosphate [NT5C1B], Gallus gallus"
xref: Reactome:REACT_83477 "AMP, dAMP, GMP, or IMP + H2O => adenosine, deoxyadenosine, guanosine, or inosine + orthophosphate [NT5E], Mus musculus"
xref: Reactome:REACT_83938 "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate [NT5C3], Gallus gallus"
xref: Reactome:REACT_84607 "AMP + H2O => adenosine + orthophosphate [NT5C1B], Rattus norvegicus"
xref: Reactome:REACT_849 "AMP, dAMP, GMP, or IMP + H2O => adenosine, deoxyadenosine, guanosine, or inosine + orthophosphate [NT5E], Homo sapiens"
xref: Reactome:REACT_84908 "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M], Taeniopygia guttata"
xref: Reactome:REACT_85028 "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E], Mus musculus"
xref: Reactome:REACT_85121 "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate [NT5C1A], Rattus norvegicus"
xref: Reactome:REACT_86373 "TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C], Xenopus tropicalis"
xref: Reactome:REACT_86597 "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E], Taeniopygia guttata"
xref: Reactome:REACT_86635 "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate [NT5C2], Canis familiaris"
xref: Reactome:REACT_87356 "AMP, dAMP, GMP, or IMP + H2O => adenosine, deoxyadenosine, guanosine, or inosine + orthophosphate [NT5E], Danio rerio"
xref: Reactome:REACT_87358 "AMP, dAMP, GMP, or IMP + H2O => adenosine, deoxyadenosine, guanosine, or inosine + orthophosphate [NT5E], Bos taurus"
xref: Reactome:REACT_87401 "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E], Canis familiaris"
xref: Reactome:REACT_88231 "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate [NT5C3], Xenopus tropicalis"
xref: Reactome:REACT_88251 "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M], Rattus norvegicus"
xref: Reactome:REACT_89239 "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate [NT5C1A], Mus musculus"
xref: Reactome:REACT_90175 "(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate [NT5C], Bos taurus"
xref: Reactome:REACT_90177 "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M], Gallus gallus"
xref: Reactome:REACT_90676 "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate [NT5C1A], Gallus gallus"
xref: Reactome:REACT_90938 "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E], Escherichia coli"
xref: Reactome:REACT_91826 "TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C], Sus scrofa"
xref: Reactome:REACT_92177 "AMP, dAMP, GMP, or IMP + H2O => adenosine, deoxyadenosine, guanosine, or inosine + orthophosphate [NT5E], Escherichia coli"
xref: Reactome:REACT_92246 "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate [NT5C2], Danio rerio"
xref: Reactome:REACT_92367 "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate [NT5C3], Rattus norvegicus"
xref: Reactome:REACT_92542 "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M], Bos taurus"
xref: Reactome:REACT_93292 "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate [NT5C2], Bos taurus"
xref: Reactome:REACT_93552 "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate [NT5C2], Oryza sativa"
xref: Reactome:REACT_93675 "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate [NT5C2], Sus scrofa"
xref: Reactome:REACT_94039 "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate [NT5C1A], Xenopus tropicalis"
xref: Reactome:REACT_95288 "AMP, dAMP, GMP, or IMP + H2O => adenosine, deoxyadenosine, guanosine, or inosine + orthophosphate [NT5E], Canis familiaris"
xref: Reactome:REACT_95623 "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M], Mus musculus"
xref: Reactome:REACT_96168 "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate [NT5C1A], Xenopus tropicalis"
xref: Reactome:REACT_96381 "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M], Canis familiaris"
xref: Reactome:REACT_96586 "AMP + H2O => adenosine + orthophosphate [NT5C1B], Bos taurus"
xref: Reactome:REACT_97321 "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate [NT5C1A], Taeniopygia guttata"
xref: Reactome:REACT_97370 "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E], Xenopus tropicalis"
xref: Reactome:REACT_97668 "TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C], Mus musculus"
xref: Reactome:REACT_97731 "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E], Rattus norvegicus"
xref: Reactome:REACT_982 "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate [NT5C1A], Homo sapiens"
xref: Reactome:REACT_99153 "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate [NT5C1A], Rattus norvegicus"
xref: Reactome:REACT_99389 "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate [NT5C1A], Sus scrofa"
is_a: GO:0008252 ! nucleotidase activity

[Term]
id: GO:0008254
name: 3'-nucleotidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 3'-ribonucleotide + H2O = a ribonucleoside + phosphate." [EC:3.1.3.6]
synonym: "3' nucleotidase activity" EXACT []
synonym: "3'-mononucleotidase activity" EXACT [EC:3.1.3.6]
synonym: "3'-phosphatase activity" EXACT [EC:3.1.3.6]
synonym: "3'-ribonucleotidase activity" EXACT [EC:3.1.3.6]
synonym: "3'-ribonucleotide phosphohydrolase activity" EXACT [EC:3.1.3.6]
xref: EC:3.1.3.6
xref: MetaCyc:3-NUCLEOTID-RXN
is_a: GO:0008252 ! nucleotidase activity

[Term]
id: GO:0008255
name: ecdysis-triggering hormone activity
namespace: molecular_function
def: "The action characteristic of ecdysis-triggering hormone, a peptide hormone that, upon receptor binding, initiates pre-ecdysis and ecdysis (i.e. cuticle shedding) through direct action on the central nervous system." [GOC:mah, PMID:9020043]
is_a: GO:0005184 ! neuropeptide hormone activity

[Term]
id: GO:0008256
name: protein histidine pros-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + protein L-histidine = ADP + protein N(pi)-phospho-L-histidine." [EC:2.7.13.1]
subset: gosubset_prok
synonym: "ATP:protein-L-histidine N-pros-phosphotransferase activity" EXACT [EC:2.7.13.1]
synonym: "ATP:protein-L-histidine Npi-phosphotransferase activity" EXACT [EC:2.7.13.1]
synonym: "HK2" RELATED [EC:2.7.13.1]
synonym: "protein-histidine pros-kinase activity" EXACT [EC:2.7.13.1]
xref: EC:2.7.13.1
xref: MetaCyc:2.7.13.1-RXN
is_a: GO:0004673 ! protein histidine kinase activity

[Term]
id: GO:0008257
name: protein histidine tele-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + protein L-histidine = ADP + protein N(tau)-phospho-L-histidine." [EC:2.7.13.2]
synonym: "ATP:protein-L-histidine N-tele-phosphotransferase activity" EXACT [EC:2.7.13.2]
synonym: "ATP:protein-L-histidine Ntau-phosphotransferase activity" EXACT [EC:2.7.13.2]
synonym: "HK3" RELATED [EC:2.7.13.2]
synonym: "protein-histidine tele-kinase activity" EXACT [EC:2.7.13.2]
xref: EC:2.7.13.2
xref: MetaCyc:2.7.13.2-RXN
is_a: GO:0004673 ! protein histidine kinase activity

[Term]
id: GO:0008258
name: head involution
namespace: biological_process
def: "Movement of the anterior ectoderm to the interior of the embryo." [ISBN:08795694238]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm

[Term]
id: GO:0008259
name: obsolete transforming growth factor beta ligand binding to type I receptor
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a function.
synonym: "TGF-beta ligand binding to type I receptor" EXACT []
synonym: "TGFbeta ligand binding to type I receptor" EXACT []
synonym: "transforming growth factor beta ligand binding to type I receptor" EXACT []
is_obsolete: true
consider: GO:0005025
consider: GO:0005160
consider: GO:0050431

[Term]
id: GO:0008260
name: 3-oxoacid CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: succinyl-CoA + a 3-oxo acid = succinate + a 3-oxo-acyl-CoA." [EC:2.8.3.5]
subset: gosubset_prok
synonym: "3-ketoacid CoA-transferase activity" EXACT [EC:2.8.3.5]
synonym: "3-ketoacid coenzyme A transferase activity" EXACT [EC:2.8.3.5]
synonym: "3-oxo-CoA transferase activity" EXACT [EC:2.8.3.5]
synonym: "3-oxoacid CoA dehydrogenase activity" EXACT [EC:2.8.3.5]
synonym: "3-oxoacid coenzyme A-transferase activity" EXACT [EC:2.8.3.5]
synonym: "acetoacetate succinyl-CoA transferase activity" EXACT [EC:2.8.3.5]
synonym: "acetoacetyl coenzyme A-succinic thiophorase activity" EXACT [EC:2.8.3.5]
synonym: "succinyl coenzyme A-acetoacetyl coenzyme A-transferase activity" EXACT [EC:2.8.3.5]
synonym: "succinyl-CoA transferase activity" EXACT [EC:2.8.3.5]
synonym: "succinyl-CoA:3-ketoacid-CoA transferase activity" EXACT [EC:2.8.3.5]
synonym: "succinyl-CoA:3-oxo-acid CoA-transferase activity" EXACT [EC:2.8.3.5]
xref: EC:2.8.3.5
xref: MetaCyc:3-OXOACID-COA-TRANSFERASE-RXN
xref: Reactome:REACT_101965 "acetoacetate + succinyl-CoA <=> acetoacetyl-CoA + succinate, Rattus norvegicus"
xref: Reactome:REACT_110993 "acetoacetate + succinyl-CoA <=> acetoacetyl-CoA + succinate, Bos taurus"
xref: Reactome:REACT_112252 "acetoacetate + succinyl-CoA <=> acetoacetyl-CoA + succinate, Xenopus tropicalis"
xref: Reactome:REACT_1796 "acetoacetate + succinyl-CoA <=> acetoacetyl-CoA + succinate, Homo sapiens"
xref: Reactome:REACT_28387 "acetoacetate + succinyl-CoA <=> acetoacetyl-CoA + succinate, Gallus gallus"
xref: Reactome:REACT_31223 "acetoacetate + succinyl-CoA <=> acetoacetyl-CoA + succinate, Danio rerio"
xref: Reactome:REACT_33458 "acetoacetate + succinyl-CoA <=> acetoacetyl-CoA + succinate, Caenorhabditis elegans"
xref: Reactome:REACT_81222 "acetoacetate + succinyl-CoA <=> acetoacetyl-CoA + succinate, Drosophila melanogaster"
xref: Reactome:REACT_82464 "acetoacetate + succinyl-CoA <=> acetoacetyl-CoA + succinate, Mycobacterium tuberculosis"
xref: Reactome:REACT_86080 "acetoacetate + succinyl-CoA <=> acetoacetyl-CoA + succinate, Mus musculus"
xref: Reactome:REACT_88464 "acetoacetate + succinyl-CoA <=> acetoacetyl-CoA + succinate, Dictyostelium discoideum"
xref: Reactome:REACT_89608 "acetoacetate + succinyl-CoA <=> acetoacetyl-CoA + succinate, Canis familiaris"
xref: Reactome:REACT_90429 "acetoacetate + succinyl-CoA <=> acetoacetyl-CoA + succinate, Taeniopygia guttata"
xref: Reactome:REACT_95458 "acetoacetate + succinyl-CoA <=> acetoacetyl-CoA + succinate, Sus scrofa"
xref: RHEA:25483
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0008261
name: allatostatin receptor activity
namespace: molecular_function
def: "Combining with allatostatin to initiate a change in cell activity." [GOC:ai]
is_a: GO:0008528 ! G-protein coupled peptide receptor activity

[Term]
id: GO:0008263
name: pyrimidine-specific mismatch base pair DNA N-glycosylase activity
namespace: molecular_function
def: "Catalysis of the removal of mismatched pyrimidine bases in DNA. Enzymes with this activity recognize and remove pyrimidines present in mismatches by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apyrimidinic (AP) site." [GOC:elh, PMID:9224623]
synonym: "G/T-mismatch-specific thymine-DNA glycosylase activity" EXACT []
is_a: GO:0000700 ! mismatch base pair DNA N-glycosylase activity

[Term]
id: GO:0008265
name: Mo-molybdopterin cofactor sulfurase activity
namespace: molecular_function
def: "Catalysis of the sulfurylation of the desulfo form of molybdenum cofactor (MoCo), a cofactor required for the activity of some enzymes, such as aldehyde oxidase." [GOC:mah, PMID:11549764]
synonym: "Mo-molybdopterin cofactor sulphurase activity" EXACT []
synonym: "molybdopterin cofactor sulfurase activity" EXACT []
synonym: "molybdopterin synthase sulfurylase activity" EXACT []
xref: Reactome:REACT_25122 "Exchange of oxygen with sulfur in MoCo, Homo sapiens"
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0008266
name: poly(U) RNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of uracil residues in an RNA molecule." [GOC:mah]
synonym: "poly(U) binding" EXACT [GOC:mah]
is_a: GO:0008187 ! poly-pyrimidine tract binding

[Term]
id: GO:0008267
name: poly-glutamine tract binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a polyglutamine tract, i.e. a series of consecutive glutamine residues, in a protein." [GOC:mah]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0008268
name: obsolete receptor signaling protein tyrosine kinase signaling protein activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because the meaning of the term is ambiguous and it incorporates process information.
synonym: "receptor signaling protein tyrosine kinase signaling protein activity" EXACT []
synonym: "receptor signalling protein tyrosine kinase signalling protein activity" EXACT []
is_obsolete: true
consider: GO:0004871
consider: GO:0035556

[Term]
id: GO:0008269
name: JAK pathway signal transduction adaptor activity
namespace: molecular_function
def: "The binding activity of a molecule that brings together two molecules of the JAK signal transduction pathway, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07]
is_a: GO:0030674 ! protein binding, bridging
is_a: GO:0035591 ! signaling adaptor activity
relationship: part_of GO:0046425 ! regulation of JAK-STAT cascade

[Term]
id: GO:0008270
name: zinc ion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
subset: gosubset_prok
synonym: "zinc binding" EXACT []
is_a: GO:0046914 ! transition metal ion binding

[Term]
id: GO:0008271
name: secondary active sulfate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport]
subset: gosubset_prok
synonym: "secondary active sulphate transmembrane transporter activity" EXACT []
synonym: "sulfate porter activity" RELATED []
synonym: "sulphate porter activity" EXACT []
is_a: GO:0015116 ! sulfate transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0008272
name: sulfate transport
namespace: biological_process
alt_id: GO:0006870
def: "The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
subset: gosubset_prok
synonym: "sulphate transport" EXACT []
is_a: GO:0015698 ! inorganic anion transport
is_a: GO:0072348 ! sulfur compound transport

[Term]
id: GO:0008273
name: calcium, potassium:sodium antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in)." [TC:2.A.19.4.1]
synonym: "potassium-dependent sodium/calcium exchanger" RELATED []
xref: Reactome:REACT_101971 "K+-dependent Na+/Ca2+ exchanger transport, Drosophila melanogaster"
xref: Reactome:REACT_107599 "K+-dependent Na+/Ca2+ exchanger transport, Rattus norvegicus"
xref: Reactome:REACT_108662 "K+-dependent Na+/Ca2+ exchanger transport, Bos taurus"
xref: Reactome:REACT_108701 "K+-dependent Na+/Ca2+ exchanger transport, Taeniopygia guttata"
xref: Reactome:REACT_110230 "K+-dependent Na+/Ca2+ exchanger transport, Caenorhabditis elegans"
xref: Reactome:REACT_19339 "K+-dependent Na+/Ca2+ exchanger transport, Homo sapiens"
xref: Reactome:REACT_79330 "K+-dependent Na+/Ca2+ exchanger transport, Xenopus tropicalis"
xref: Reactome:REACT_82439 "K+-dependent Na+/Ca2+ exchanger transport, Mus musculus"
xref: Reactome:REACT_95185 "K+-dependent Na+/Ca2+ exchanger transport, Canis familiaris"
xref: Reactome:REACT_96629 "K+-dependent Na+/Ca2+ exchanger transport, Sus scrofa"
xref: Reactome:REACT_97287 "K+-dependent Na+/Ca2+ exchanger transport, Gallus gallus"
xref: Reactome:REACT_98675 "K+-dependent Na+/Ca2+ exchanger transport, Danio rerio"
is_a: GO:0015081 ! sodium ion transmembrane transporter activity
is_a: GO:0015368 ! calcium:cation antiporter activity
is_a: GO:0022821 ! potassium ion antiporter activity

[Term]
id: GO:0008274
name: gamma-tubulin ring complex
namespace: cellular_component
def: "A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins that forms a flexible open ring structure thought to be the unit of nucleation at the minus end of a microtubule." [GOC:clt, PMID:12134075]
synonym: "gammaTuRC" EXACT []
is_a: GO:0000931 ! gamma-tubulin large complex

[Term]
id: GO:0008275
name: gamma-tubulin small complex
namespace: cellular_component
def: "A complex usually comprising two gamma-tubulin molecules and two conserved non-tubulin proteins. Some gamma-tubulin small complexes are thought to be the repeating unit making up the core of the gamma-tubulin ring complex." [PMID:11297925, PMID:12134075]
synonym: "gammaTuSC" EXACT []
is_a: GO:0000930 ! gamma-tubulin complex

[Term]
id: GO:0008276
name: protein methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group (CH3-) to a protein." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
xref: EC:2.1.1.-
is_a: GO:0008168 ! methyltransferase activity
relationship: part_of GO:0006479 ! protein methylation

[Term]
id: GO:0008277
name: regulation of G-protein coupled receptor protein signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity." [GOC:go_curators]
synonym: "regulation of G protein coupled receptor protein signaling pathway" EXACT []
synonym: "regulation of G protein coupled receptor protein signalling pathway" EXACT []
synonym: "regulation of G-protein coupled receptor protein signalling pathway" EXACT []
synonym: "regulation of G-protein-coupled receptor protein signaling pathway" EXACT []
synonym: "regulation of G-protein-coupled receptor protein signalling pathway" EXACT []
synonym: "regulation of GPCR protein signaling pathway" EXACT []
synonym: "regulation of GPCR protein signalling pathway" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007186 ! G-protein coupled receptor signaling pathway
relationship: regulates GO:0007186 ! G-protein coupled receptor signaling pathway

[Term]
id: GO:0008278
name: cohesin complex
namespace: cellular_component
alt_id: GO:0008279
alt_id: GO:0043222
def: "A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3)." [GOC:sp, PMID:9887095]
subset: goslim_pir
synonym: "14S cohesin" NARROW []
synonym: "SMC complex" RELATED []
synonym: "SMC/kleisin ring complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000793 ! condensed chromosome

[Term]
id: GO:0008280
name: cohesin core heterodimer
namespace: cellular_component
def: "The core heterodimer of a cohesin complex; a structure required for sister chromatid cohesion in eukaryotes." [GOC:jl]
synonym: "9S cohesin" NARROW []
synonym: "Smc1-Smc3 complex" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
intersection_of: GO:0043234 ! protein complex
intersection_of: part_of GO:0008278 ! cohesin complex
relationship: part_of GO:0008278 ! cohesin complex

[Term]
id: GO:0008281
name: sulfonylurea receptor activity
namespace: molecular_function
def: "Combining with sulfonylurea, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:ai, GOC:signaling]
comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'potassium channel activity ; GO:0005267'.
synonym: "sulphonylurea receptor activity" EXACT []
is_a: GO:0004888 ! transmembrane signaling receptor activity

[Term]
id: GO:0008282
name: ATP-sensitive potassium channel complex
namespace: cellular_component
def: "A protein complex that comprises four pore-forming (Kir6.x) and four regulatory sulphonylurea receptor (SURx) subunits and forms a transmembrane channel through which ions may pass. The opening and closing of the channel is regulated by ATP: binding of ATP to the Kir6.x subunit inhibits channel activity, whereas binding of Mg2+-complexed ATP or ADP to the SURx subunit stimulates channel activity." [GOC:bhm, PMID:16308567, PMID:16956886]
is_a: GO:0034705 ! potassium channel complex
is_a: GO:0098797 ! plasma membrane protein complex
relationship: part_of GO:0005887 ! integral component of plasma membrane

[Term]
id: GO:0008283
name: cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]
comment: This term was moved out from being a child of 'cellular process' because it is a cell population-level process, and cellular processes are restricted to those processes that involve individual cells. Also note that this term is intended to be used for the proliferation of cells within a multicellular organism, not for the expansion of a population of single-celled organisms.
subset: goslim_chembl
subset: goslim_generic
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0044699 ! single-organism process

[Term]
id: GO:0008284
name: positive regulation of cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of cell proliferation" NARROW []
synonym: "stimulation of cell proliferation" NARROW []
synonym: "up regulation of cell proliferation" EXACT []
synonym: "up-regulation of cell proliferation" EXACT []
synonym: "upregulation of cell proliferation" EXACT []
is_a: GO:0042127 ! regulation of cell proliferation
is_a: GO:0048522 ! positive regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008283 ! cell proliferation
relationship: positively_regulates GO:0008283 ! cell proliferation

[Term]
id: GO:0008285
name: negative regulation of cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators]
synonym: "down regulation of cell proliferation" EXACT []
synonym: "down-regulation of cell proliferation" EXACT []
synonym: "downregulation of cell proliferation" EXACT []
synonym: "inhibition of cell proliferation" NARROW []
is_a: GO:0042127 ! regulation of cell proliferation
is_a: GO:0048523 ! negative regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008283 ! cell proliferation
relationship: negatively_regulates GO:0008283 ! cell proliferation

[Term]
id: GO:0008286
name: insulin receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of the insulin receptor binding to insulin." [GOC:ceb]
synonym: "daf-2 receptor signaling pathway" NARROW []
synonym: "insulin receptor signalling pathway" EXACT []
xref: Reactome:REACT_101230 "Signaling by Insulin receptor, Mus musculus"
xref: Reactome:REACT_101830 "Signaling by Insulin receptor, Oryza sativa"
xref: Reactome:REACT_102947 "Signaling by Insulin receptor, Taeniopygia guttata"
xref: Reactome:REACT_103763 "Signaling by Insulin receptor, Dictyostelium discoideum"
xref: Reactome:REACT_104267 "Signaling by Insulin receptor, Xenopus tropicalis"
xref: Reactome:REACT_109415 "Signaling by Insulin receptor, Canis familiaris"
xref: Reactome:REACT_28335 "Signaling by Insulin receptor, Saccharomyces cerevisiae"
xref: Reactome:REACT_29837 "Signaling by Insulin receptor, Plasmodium falciparum"
xref: Reactome:REACT_498 "Signaling by Insulin receptor, Homo sapiens"
xref: Reactome:REACT_6313 "Signaling by Insulin receptor, Drosophila melanogaster"
xref: Reactome:REACT_67136 "Signaling by Insulin receptor, Bos taurus"
xref: Reactome:REACT_78672 "Signaling by Insulin receptor, Caenorhabditis elegans"
xref: Reactome:REACT_83616 "Signaling by Insulin receptor, Schizosaccharomyces pombe"
xref: Reactome:REACT_90882 "Signaling by Insulin receptor, Sus scrofa"
xref: Reactome:REACT_95985 "Signaling by Insulin receptor, Danio rerio"
xref: Reactome:REACT_97488 "Signaling by Insulin receptor, Arabidopsis thaliana"
xref: Reactome:REACT_99009 "Signaling by Insulin receptor, Rattus norvegicus"
xref: Reactome:REACT_99439 "Signaling by Insulin receptor, Gallus gallus"
is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway
relationship: part_of GO:0032869 ! cellular response to insulin stimulus

[Term]
id: GO:0008287
name: protein serine/threonine phosphatase complex
namespace: cellular_component
def: "A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein." [GOC:bf]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0044464 ! cell part
is_a: GO:1903293 ! phosphatase complex

[Term]
id: GO:0008288
name: boss receptor activity
namespace: molecular_function
def: "Combining with a protein bride of sevenless (boss) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [GOC:jl, GOC:signaling]
synonym: "sevenless receptor activity" RELATED []
is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity

[Term]
id: GO:0008289
name: lipid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a lipid." [GOC:ai]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0008290
name: F-actin capping protein complex
namespace: cellular_component
def: "A heterodimer consisting of alpha and beta subunits that binds to and caps the barbed ends of actin filaments, thereby regulating the polymerization of actin monomers but not severing actin filaments." [GOC:go_curators, ISBN:0198599560]
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0015629 ! actin cytoskeleton

[Term]
id: GO:0008291
name: acetylcholine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:jl, GOC:nln, ISBN:0192800752]
synonym: "acetylcholine metabolism" EXACT []
is_a: GO:0042133 ! neurotransmitter metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0097164 ! ammonium ion metabolic process
is_a: GO:1900619 ! acetate ester metabolic process

[Term]
id: GO:0008292
name: acetylcholine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of acetylcholine, the acetic acid ester of the organic base choline." [GOC:jl, ISBN:0192800752]
synonym: "acetylcholine anabolism" EXACT []
synonym: "acetylcholine biosynthesis" EXACT []
synonym: "acetylcholine formation" EXACT []
synonym: "acetylcholine synthesis" EXACT []
is_a: GO:0008291 ! acetylcholine metabolic process
is_a: GO:0042136 ! neurotransmitter biosynthetic process
is_a: GO:1900620 ! acetate ester biosynthetic process

[Term]
id: GO:0008293
name: torso signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of an extracellular ligand to torso (a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:8343949]
synonym: "torso signalling pathway" EXACT []
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway

[Term]
id: GO:0008294
name: calcium- and calmodulin-responsive adenylate cyclase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate, stimulated by calcium-bound calmodulin." [EC:4.6.1.1, GOC:mah]
synonym: "calcium- and calmodulin-responsive adenylyl cyclase activity" EXACT []
synonym: "calcium/calmodulin-responsive adenylate cyclase activity" EXACT []
xref: Reactome:REACT_107461 "Adenylate cyclase produces cAMP, Mycobacterium tuberculosis"
xref: Reactome:REACT_107884 "Adenylate cyclase produces cAMP, Bos taurus"
xref: Reactome:REACT_110620 "Adenylate cyclase produces cAMP, Sus scrofa"
xref: Reactome:REACT_1963 "Adenylate cyclase produces cAMP, Homo sapiens"
xref: Reactome:REACT_32245 "Adenylate cyclase produces cAMP, Gallus gallus"
xref: Reactome:REACT_32489 "Adenylate cyclase produces cAMP, Drosophila melanogaster"
xref: Reactome:REACT_32897 "Adenylate cyclase produces cAMP, Canis familiaris"
xref: Reactome:REACT_82987 "Adenylate cyclase produces cAMP, Danio rerio"
xref: Reactome:REACT_84582 "Adenylate cyclase produces cAMP, Caenorhabditis elegans"
xref: Reactome:REACT_86114 "Adenylate cyclase produces cAMP, Taeniopygia guttata"
xref: Reactome:REACT_88462 "Adenylate cyclase produces cAMP, Mus musculus"
xref: Reactome:REACT_89384 "Adenylate cyclase produces cAMP, Rattus norvegicus"
xref: Reactome:REACT_94028 "Adenylate cyclase produces cAMP, Xenopus tropicalis"
is_a: GO:0004016 ! adenylate cyclase activity

[Term]
id: GO:0008295
name: spermidine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "spermidine anabolism" EXACT []
synonym: "spermidine biosynthesis" EXACT []
synonym: "spermidine formation" EXACT []
synonym: "spermidine synthesis" EXACT []
xref: MetaCyc:BSUBPOLYAMSYN-PWY
xref: MetaCyc:POLYAMINSYN3-PWY
is_a: GO:0006596 ! polyamine biosynthetic process
is_a: GO:0008216 ! spermidine metabolic process

[Term]
id: GO:0008296
name: 3'-5'-exodeoxyribonuclease activity
namespace: molecular_function
def: "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a DNA molecule." [GOC:mah]
synonym: "3'-5' exodeoxyribonuclease activity" EXACT []
xref: Reactome:REACT_27164 "Removal of SPO11 and Resection of 5' Ends of DNA (yeast), Saccharomyces cerevisiae"
xref: Reactome:REACT_27209 "Removal of SPO11 and Resection of 5' Ends of DNA, Homo sapiens"
is_a: GO:0008408 ! 3'-5' exonuclease activity
is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0008297
name: single-stranded DNA exodeoxyribonuclease activity
namespace: molecular_function
def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a single-stranded DNA molecule." [GOC:mah]
subset: gosubset_prok
synonym: "single-stranded DNA specific exodeoxyribonuclease activity" RELATED []
synonym: "ssDNA-specific exodeoxyribonuclease activity" RELATED [GOC:mah]
is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0008298
name: intracellular mRNA localization
namespace: biological_process
def: "Any process in which mRNA is transported to, or maintained in, a specific location within the cell." [GOC:ai]
synonym: "establishment and maintenance of intracellular RNA localization" EXACT []
synonym: "intracellular mRNA localisation" EXACT [GOC:mah]
synonym: "intracellular mRNA positioning" NARROW []
synonym: "mRNA localization, intracellular" EXACT []
synonym: "mRNA positioning, intracellular" NARROW []
is_a: GO:0006403 ! RNA localization
is_a: GO:0070727 ! cellular macromolecule localization

[Term]
id: GO:0008299
name: isoprenoid biosynthetic process
namespace: biological_process
alt_id: GO:0009241
def: "The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732]
subset: gosubset_prok
synonym: "isoprenoid anabolism" EXACT []
synonym: "isoprenoid biosynthesis" EXACT []
synonym: "isoprenoid formation" EXACT []
synonym: "isoprenoid synthesis" EXACT []
synonym: "polyisoprenoid anabolism" NARROW []
synonym: "polyisoprenoid biosynthesis" NARROW []
synonym: "polyisoprenoid biosynthetic process" NARROW []
synonym: "polyisoprenoid formation" NARROW []
synonym: "polyisoprenoid synthesis" NARROW []
synonym: "polyterpene biosynthesis" NARROW []
synonym: "polyterpene biosynthetic process" NARROW []
xref: MetaCyc:POLYISOPRENSYN-PWY
is_a: GO:0006720 ! isoprenoid metabolic process
is_a: GO:0008610 ! lipid biosynthetic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0008300
name: isoprenoid catabolic process
namespace: biological_process
alt_id: GO:0016097
def: "The chemical reactions and pathways resulting in the breakdown of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732]
subset: gosubset_prok
synonym: "isoprenoid breakdown" EXACT []
synonym: "isoprenoid catabolism" EXACT []
synonym: "isoprenoid degradation" EXACT []
synonym: "polyisoprenoid breakdown" NARROW []
synonym: "polyisoprenoid catabolic process" NARROW []
synonym: "polyisoprenoid catabolism" NARROW []
synonym: "polyisoprenoid degradation" NARROW []
synonym: "polyterpene catabolic process" NARROW []
synonym: "polyterpene catabolism" NARROW []
is_a: GO:0006720 ! isoprenoid metabolic process
is_a: GO:0044242 ! cellular lipid catabolic process

[Term]
id: GO:0008301
name: DNA binding, bending
namespace: molecular_function
def: "The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:krc, GOC:vw, PMID:10710711, PMID:19037758]
subset: gosubset_prok
synonym: "DNA bending activity" EXACT []
synonym: "DNA bending involving DNA binding" EXACT []
is_a: GO:0003677 ! DNA binding

[Term]
id: GO:0008302
name: female germline ring canal formation, actin assembly
namespace: biological_process
def: "Recruitment and organization of actin filaments in female germline ring canals." [ISBN:0879694238]
synonym: "nurse cell ring canal formation, actin assembly" NARROW []
synonym: "ovarian ring canal formation, actin assembly" NARROW []
synonym: "ring canal formation, actin assembly" BROAD []
is_a: GO:0007015 ! actin filament organization
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
relationship: part_of GO:0007301 ! female germline ring canal formation

[Term]
id: GO:0008303
name: caspase complex
namespace: cellular_component
def: "A protein complex that is located in the cytosol and contains one or more cysteine-type endopeptidases (also called caspases), which give the complex a peptidase activity with specificity for the hydrolysis of aspartyl bonds. These complexes may be involved e.g. in apoptotic or inflammation processes." [GOC:cna, GOC:mtg_apoptosis]
comment: Note that this term was reinstated from obsolete.
synonym: "cysteine-type endopeptidase complex" EXACT [GOC:pr]
is_a: GO:0044445 ! cytosolic part
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0008304
name: obsolete eukaryotic translation initiation factor 4 complex
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because more specific terms were created.
synonym: "eIF-4" EXACT []
synonym: "eukaryotic translation initiation factor 4 complex" EXACT []
is_obsolete: true
replaced_by: GO:0016281

[Term]
id: GO:0008305
name: integrin complex
namespace: cellular_component
def: "A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands." [PMID:17543136]
subset: gosubset_prok
synonym: "laminin receptor protein" RELATED []
is_a: GO:0098636 ! protein complex involved in cell adhesion
is_a: GO:0098802 ! plasma membrane receptor complex
relationship: part_of GO:0005887 ! integral component of plasma membrane

[Term]
id: GO:0008306
name: associative learning
namespace: biological_process
def: "Learning by associating a stimulus (the cause) with a particular outcome (the effect)." [ISBN:0582227089]
synonym: "classical conditioning" EXACT []
synonym: "conditional learning" EXACT []
synonym: "conditional response" EXACT []
synonym: "Pavlovian conditioning" EXACT []
xref: Wikipedia:Learning#Associative_learning
is_a: GO:0007612 ! learning

[Term]
id: GO:0008307
name: structural constituent of muscle
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of a muscle fiber." [GOC:mah]
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0008308
name: voltage-gated anion channel activity
namespace: molecular_function
alt_id: GO:0022844
def: "Enables the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, GOC:vw, ISBN:0815340729]
synonym: "voltage-dependent ion-selective channel activity" RELATED []
synonym: "voltage-gated ion-selective channel activity" RELATED []
is_a: GO:0005244 ! voltage-gated ion channel activity
is_a: GO:0005253 ! anion channel activity
relationship: part_of GO:1903959 ! regulation of anion transmembrane transport

[Term]
id: GO:0008309
name: double-stranded DNA exodeoxyribonuclease activity
namespace: molecular_function
def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a double-stranded DNA molecule." [GOC:mah]
synonym: "double-stranded DNA specific exodeoxyribonuclease activity" RELATED []
is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0008310
name: single-stranded DNA 3'-5' exodeoxyribonuclease activity
namespace: molecular_function
def: "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a single-stranded DNA molecule." [GOC:mah, PMID:22562358]
synonym: "single-stranded DNA specific 3'-5' exodeoxyribonuclease activity" RELATED []
synonym: "ssDNA-specific 3'-5' exodeoxyribonuclease activity" RELATED [GOC:mah]
is_a: GO:0008296 ! 3'-5'-exodeoxyribonuclease activity
is_a: GO:0008297 ! single-stranded DNA exodeoxyribonuclease activity

[Term]
id: GO:0008311
name: double-stranded DNA 3'-5' exodeoxyribonuclease activity
namespace: molecular_function
def: "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a double-stranded DNA molecule." [GOC:mah, PMID:22562358]
synonym: "double-stranded DNA specific 3'-5' exodeoxyribonuclease activity" RELATED []
is_a: GO:0008296 ! 3'-5'-exodeoxyribonuclease activity
is_a: GO:0008309 ! double-stranded DNA exodeoxyribonuclease activity

[Term]
id: GO:0008312
name: 7S RNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with 7S RNA, the RNA component of the signal recognition particle (SRP)." [GOC:jl, PMID:6181418]
subset: gosubset_prok
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0008313
name: gurken-activated receptor activity
namespace: molecular_function
def: "Combining with the ligand Gurken to initiate a change in cell activity." [GOC:bf]
synonym: "gurken receptor activity" EXACT [GOC:bf, GOC:signaling]
is_a: GO:0005006 ! epidermal growth factor-activated receptor activity

[Term]
id: GO:0008314
name: gurken signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to the ligand Gurken." [GOC:bf, PMID:23972992]
synonym: "gurken receptor signaling pathway" EXACT []
synonym: "gurken receptor signalling pathway" EXACT []
synonym: "gurken-activated signaling pathway" RELATED [GOC:signaling]
synonym: "signaling by Gurken" EXACT [GOC:bf]
is_a: GO:0007173 ! epidermal growth factor receptor signaling pathway

[Term]
id: GO:0008315
name: meiotic G2/MI transition
namespace: biological_process
def: "The cell cycle process in which a cell progresses from meiotic prophase to metaphase I." [PMID:15088480]
synonym: "meiotic cell cycle G2/MI phase transition" EXACT []
synonym: "meiotic G2/MI phase transition" EXACT []
is_a: GO:0044771 ! meiotic cell cycle phase transition
is_a: GO:0044839 ! cell cycle G2/M phase transition
intersection_of: GO:0044839 ! cell cycle G2/M phase transition
intersection_of: part_of GO:0051321 ! meiotic cell cycle
relationship: part_of GO:0007127 ! meiosis I
relationship: part_of GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0008316
name: structural constituent of vitelline membrane
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of the vitelline membrane of an egg. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:sensu]
is_a: GO:0035804 ! structural constituent of egg coat

[Term]
id: GO:0008317
name: gurken receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the gurken growth factor receptor." [GOC:ai]
synonym: "gurken receptor ligand" NARROW []
is_a: GO:0005154 ! epidermal growth factor receptor binding

[Term]
id: GO:0008318
name: protein prenyltransferase activity
namespace: molecular_function
alt_id: GO:0008244
def: "Catalysis of the covalent addition of an isoprenoid group such as a farnesyl or geranylgeranyl group via thioether linkages to a cysteine residue in a protein." [GOC:mah]
xref: EC:2.5.1.-
is_a: GO:0004659 ! prenyltransferase activity

[Term]
id: GO:0008319
name: obsolete prenyl protein specific endopeptidase activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "prenyl protein specific endopeptidase activity" EXACT []
xref: EC:3.4.24.-
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0008320
name: protein transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a protein from one side of a membrane to the other." [GOC:jl]
subset: gosubset_prok
is_a: GO:0008565 ! protein transporter activity
is_a: GO:0022884 ! macromolecule transmembrane transporter activity
relationship: part_of GO:0071806 ! protein transmembrane transport

[Term]
id: GO:0008321
name: Ral guanyl-nucleotide exchange factor activity
namespace: molecular_function
alt_id: GO:0016220
def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ral family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
synonym: "Ral GDP-dissociation stimulator activity" EXACT []
xref: Reactome:REACT_110480 "Guanine nucleotide exchange on RAL, Bos taurus"
xref: Reactome:REACT_111942 "Guanine nucleotide exchange on RAL, Xenopus tropicalis"
xref: Reactome:REACT_115506 "Guanine nucleotide exchange on RAL, Taeniopygia guttata"
xref: Reactome:REACT_115986 "Guanine nucleotide exchange on Ral, Rattus norvegicus"
xref: Reactome:REACT_12041 "Guanine nucleotide exchange on RAL, Homo sapiens"
xref: Reactome:REACT_30460 "Guanine nucleotide exchange on RAL, Mus musculus"
xref: Reactome:REACT_31061 "Guanine nucleotide exchange on RAL, Drosophila melanogaster"
xref: Reactome:REACT_77293 "Guanine nucleotide exchange on RAL, Danio rerio"
xref: Reactome:REACT_77317 "Guanine nucleotide exchange on RAL, Canis familiaris"
xref: Reactome:REACT_78362 "Guanine nucleotide exchange on RAL, Gallus gallus"
is_a: GO:0005088 ! Ras guanyl-nucleotide exchange factor activity

[Term]
id: GO:0008322
name: obsolete Pro-X carboxypeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of a Pro-Xaa bond to release a C-terminal amino acid." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "Pro-X carboxypeptidase activity" EXACT []
is_obsolete: true
replaced_by: GO:0030536

[Term]
id: GO:0008324
name: cation transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of cation from one side of the membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "transmembrane cation transporter activity" EXACT []
is_a: GO:0015075 ! ion transmembrane transporter activity
relationship: part_of GO:0098655 ! cation transmembrane transport

[Term]
id: GO:0008327
name: methyl-CpG binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a methylated cytosine/guanine dinucleotide." [GOC:jl, PMID:11746232]
is_a: GO:0000166 ! nucleotide binding
is_a: GO:0043565 ! sequence-specific DNA binding

[Term]
id: GO:0008328
name: ionotropic glutamate receptor complex
namespace: cellular_component
def: "A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand-gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex." [http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html]
is_a: GO:0034702 ! ion channel complex
is_a: GO:0098802 ! plasma membrane receptor complex
relationship: part_of GO:0005887 ! integral component of plasma membrane

[Term]
id: GO:0008329
name: signaling pattern recognition receptor activity
namespace: molecular_function
def: "Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species, or damage-associated molecular pattern (DAMP), an endogenous molecule released from damaged cells), and transmitting a signal to initiate a change in cell activity." [GOC:ar, PMID:12507420, PMID:12925128, PMID:14523544, Wikipedia:Pattern_recognition_receptor]
comment: This term and its child terms are intended for gene products which are directly coupled to a signal transduction pathway. For pattern recognition receptors which do not relay an intracellular signal (e.g. endocytic pattern recognition receptors), consider instead annotating to 'pattern recognition receptor activity ; GO:0038187' and/or the child terms of 'pattern binding ; GO:0001871'. Note that many gene products that are called pattern recognition receptors in the literature have a broad range of potential ligands and also can be annotated to 'scavenger receptor activity ; GO:0005044'.
synonym: "macrophage receptor activity" RELATED []
synonym: "signaling PRR activity" EXACT [Wikipedia:Pattern_recognition_receptor]
is_a: GO:0038023 ! signaling receptor activity
is_a: GO:0038187 ! pattern recognition receptor activity
relationship: part_of GO:0002221 ! pattern recognition receptor signaling pathway

[Term]
id: GO:0008330
name: protein tyrosine/threonine phosphatase activity
namespace: molecular_function
def: "Catalysis of the reactions: protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]
xref: EC:3.1.3.-
is_a: GO:0004721 ! phosphoprotein phosphatase activity

[Term]
id: GO:0008331
name: high voltage-gated calcium channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729, PMID:16382099]
synonym: "high voltage gated calcium channel activity" EXACT []
synonym: "high voltage-dependent calcium channel activity" EXACT []
synonym: "L-type calcium channel" RELATED []
synonym: "N-type calcium channel" RELATED []
synonym: "P-type calcium channel" RELATED []
synonym: "Q-type calcium channel" RELATED []
is_a: GO:0005245 ! voltage-gated calcium channel activity

[Term]
id: GO:0008332
name: low voltage-gated calcium channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a calcium ion by a low voltage-gated channel. A low voltage-gated channel is a channel whose open state is dependent on low voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729, PMID:16382099]
synonym: "low voltage gated calcium channel activity" EXACT []
synonym: "low voltage-dependent calcium channel activity" EXACT []
synonym: "T-type calcium channel" RELATED []
is_a: GO:0005245 ! voltage-gated calcium channel activity

[Term]
id: GO:0008333
name: endosome to lysosome transport
namespace: biological_process
def: "The directed movement of substances from endosomes to lysosomes." [GOC:ai, ISBN:0716731363]
is_a: GO:0007041 ! lysosomal transport
is_a: GO:0016197 ! endosomal transport

[Term]
id: GO:0008334
name: histone mRNA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an mRNA encoding a histone." [GOC:krc, GOC:mah, PMID:17855393]
comment: In higher Eukaryotes, histone mRNAs (stem-loop containing) are non-polyadenylated and thus have a different form of 3'-end regulation to other mRNAs. In lower Eukaryotes, the 3'-ends of histone mRNAs are polyadenylated.
synonym: "histone mRNA metabolism" EXACT []
synonym: "stem-loop-containing histone mRNA 3'-end processing" NARROW [GOC:krc, GOC:mah, PMID:17855393]
xref: Reactome:REACT_100387 "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs, Canis familiaris"
xref: Reactome:REACT_101970 "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA, Xenopus tropicalis"
xref: Reactome:REACT_102988 "Binding of SLBP to Replication-Dependent Histone Pre-mRNA, Gallus gallus"
xref: Reactome:REACT_103041 "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs, Bos taurus"
xref: Reactome:REACT_105954 "SLBP independent Processing of Histone Pre-mRNAs, Bos taurus"
xref: Reactome:REACT_108959 "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs, Taeniopygia guttata"
xref: Reactome:REACT_109290 "Binding of SLBP to Replication-Dependent Histone Pre-mRNA, Xenopus tropicalis"
xref: Reactome:REACT_109588 "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs, Xenopus tropicalis"
xref: Reactome:REACT_112727 "SLBP independent Processing of Histone Pre-mRNAs, Danio rerio"
xref: Reactome:REACT_112752 "Binding of SLBP to Replication-Dependent Histone Pre-mRNA, Caenorhabditis elegans"
xref: Reactome:REACT_112829 "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs, Caenorhabditis elegans"
xref: Reactome:REACT_113324 "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA, Danio rerio"
xref: Reactome:REACT_113499 "Binding of SLBP to Replication-Dependent Histone Pre-mRNA, Dictyostelium discoideum"
xref: Reactome:REACT_113687 "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA, Caenorhabditis elegans"
xref: Reactome:REACT_113849 "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA, Drosophila melanogaster"
xref: Reactome:REACT_113897 "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA, Drosophila melanogaster"
xref: Reactome:REACT_114009 "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs, Drosophila melanogaster"
xref: Reactome:REACT_114040 "SLBP independent Processing of Histone Pre-mRNAs, Drosophila melanogaster"
xref: Reactome:REACT_114133 "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA, Caenorhabditis elegans"
xref: Reactome:REACT_114241 "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs, Dictyostelium discoideum"
xref: Reactome:REACT_115024 "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs, Danio rerio"
xref: Reactome:REACT_115064 "Binding of SLBP to Replication-Dependent Histone Pre-mRNA, Drosophila melanogaster"
xref: Reactome:REACT_115116 "Binding of SLBP to Replication-Dependent Histone Pre-mRNA, Danio rerio"
xref: Reactome:REACT_115510 "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA, Danio rerio"
xref: Reactome:REACT_115517 "SLBP independent Processing of Histone Pre-mRNAs, Caenorhabditis elegans"
xref: Reactome:REACT_1364 "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs, Homo sapiens"
xref: Reactome:REACT_1591 "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA, Homo sapiens"
xref: Reactome:REACT_185 "SLBP independent Processing of Histone Pre-mRNAs, Homo sapiens"
xref: Reactome:REACT_28587 "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs, Gallus gallus"
xref: Reactome:REACT_29376 "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA, Gallus gallus"
xref: Reactome:REACT_30815 "SLBP independent Processing of Histone Pre-mRNAs, Gallus gallus"
xref: Reactome:REACT_32690 "Binding of SLBP to Replication-Dependent Histone Pre-mRNA, Canis familiaris"
xref: Reactome:REACT_33414 "Binding of SLBP to Replication-Dependent Histone Pre-mRNA, Taeniopygia guttata"
xref: Reactome:REACT_42352 "Binding of SLBP to Replication-Dependent Histone Pre-mRNA, Bos taurus"
xref: Reactome:REACT_706 "Binding of SLBP to Replication-Dependent Histone Pre-mRNA, Homo sapiens"
xref: Reactome:REACT_78118 "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA, Rattus norvegicus"
xref: Reactome:REACT_78253 "SLBP independent Processing of Histone Pre-mRNAs, Rattus norvegicus"
xref: Reactome:REACT_78429 "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA, Rattus norvegicus"
xref: Reactome:REACT_80494 "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA, Gallus gallus"
xref: Reactome:REACT_84669 "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA, Bos taurus"
xref: Reactome:REACT_84828 "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs, Sus scrofa"
xref: Reactome:REACT_85098 "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA, Bos taurus"
xref: Reactome:REACT_85791 "Binding of SLBP to Replication-Dependent Histone Pre-mRNA, Mus musculus"
xref: Reactome:REACT_86778 "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA, Mus musculus"
xref: Reactome:REACT_90814 "Binding of SLBP to Replication-Dependent Histone Pre-mRNA, Rattus norvegicus"
xref: Reactome:REACT_94206 "SLBP independent Processing of Histone Pre-mRNAs, Mus musculus"
xref: Reactome:REACT_94716 "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA, Mus musculus"
xref: Reactome:REACT_94994 "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs, Rattus norvegicus"
xref: Reactome:REACT_967 "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA, Homo sapiens"
xref: Reactome:REACT_97573 "SLBP independent Processing of Histone Pre-mRNAs, Xenopus tropicalis"
xref: Reactome:REACT_97772 "Binding of SLBP to Replication-Dependent Histone Pre-mRNA, Sus scrofa"
xref: Reactome:REACT_98594 "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA, Xenopus tropicalis"
xref: Reactome:REACT_99292 "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs, Mus musculus"
is_a: GO:0016071 ! mRNA metabolic process

[Term]
id: GO:0008335
name: female germline ring canal stabilization
namespace: biological_process
def: "Maintenance of the structural integrity of the ring canals connecting the female germline cyst." [GOC:curators]
synonym: "nurse cell ring canal stabilization" NARROW []
synonym: "ovarian ring canal stabilization" NARROW []
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0031032 ! actomyosin structure organization
relationship: part_of GO:0007300 ! ovarian nurse cell to oocyte transport

[Term]
id: GO:0008336
name: gamma-butyrobetaine dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + 4-(trimethylammonio)butanoate + O(2) = carnitine + CO(2) + succinate." [EC:1.14.11.1, RHEA:24031]
subset: gosubset_prok
synonym: "4-trimethylammoniobutanoate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.11.1]
synonym: "alpha-butyrobetaine hydroxylase activity" EXACT [EC:1.14.11.1]
synonym: "butyrobetaine hydroxylase activity" EXACT [EC:1.14.11.1]
synonym: "g-butyrobetaine dioxygenase activity" EXACT []
synonym: "gamma-BBH activity" EXACT [EC:1.14.11.1]
synonym: "gamma-butyrobetaine hydroxylase activity" EXACT [EC:1.14.11.1]
synonym: "gamma-butyrobetaine,2-oxoglutarate dioxygenase activity" EXACT []
xref: EC:1.14.11.1
xref: KEGG:R02397
xref: MetaCyc:1.14.11.1-RXN
xref: Reactome:REACT_104520 "gamma-butyrobetaine + alpha-ketoglutarate + O2 => carnitine + succinate + CO2, Danio rerio"
xref: Reactome:REACT_106549 "gamma-butyrobetaine + alpha-ketoglutarate + O2 => carnitine + succinate + CO2, Rattus norvegicus"
xref: Reactome:REACT_107142 "gamma-butyrobetaine + alpha-ketoglutarate + O2 => carnitine + succinate + CO2, Canis familiaris"
xref: Reactome:REACT_110968 "gamma-butyrobetaine + alpha-ketoglutarate + O2 => carnitine + succinate + CO2, Gallus gallus"
xref: Reactome:REACT_114022 "gamma-butyrobetaine + alpha-ketoglutarate + O2 => carnitine + succinate + CO2, Saccharomyces cerevisiae"
xref: Reactome:REACT_33758 "gamma-butyrobetaine + alpha-ketoglutarate + O2 => carnitine + succinate + CO2, Sus scrofa"
xref: Reactome:REACT_36506 "gamma-butyrobetaine + alpha-ketoglutarate + O2 => carnitine + succinate + CO2, Caenorhabditis elegans"
xref: Reactome:REACT_417 "gamma-butyrobetaine + alpha-ketoglutarate + O2 => carnitine + succinate + CO2, Homo sapiens"
xref: Reactome:REACT_84897 "gamma-butyrobetaine + alpha-ketoglutarate + O2 => carnitine + succinate + CO2, Taeniopygia guttata"
xref: Reactome:REACT_88672 "gamma-butyrobetaine + alpha-ketoglutarate + O2 => carnitine + succinate + CO2, Xenopus tropicalis"
xref: Reactome:REACT_90390 "gamma-butyrobetaine + alpha-ketoglutarate + O2 => carnitine + succinate + CO2, Bos taurus"
xref: Reactome:REACT_95474 "gamma-butyrobetaine + alpha-ketoglutarate + O2 => carnitine + succinate + CO2, Mus musculus"
xref: RHEA:24031
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0008337
name: obsolete selectin
namespace: molecular_function
def: "OBSOLETE. A class of cell adhesion molecules that bind to carbohydrate via a lectin-like domain; integral membrane glycoproteins." [ISBN:0124325653]
comment: This term was made obsolete because it describes a class of gene products.
synonym: "selectin" EXACT []
is_obsolete: true
consider: GO:0005102
consider: GO:0007155
consider: GO:0016021
consider: GO:0030246
consider: GO:0050839

[Term]
id: GO:0008340
name: determination of adult lifespan
namespace: biological_process
def: "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
is_a: GO:0044707 ! single-multicellular organism process
relationship: part_of GO:0010259 ! multicellular organism aging

[Term]
id: GO:0008341
name: obsolete response to cocaine (sensu Insecta)
namespace: biological_process
def: "OBSOLETE. A change in state or activity of a mature individual as the result of a cocaine stimulus. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557)." [GOC:go_curators, GOC:jid]
comment: This term was made obsolete because there is no clear difference between the sensu Insecta term and the generic term.
synonym: "response to cocaine (sensu Insecta)" EXACT []
is_obsolete: true
consider: GO:0048148

[Term]
id: GO:0008342
name: obsolete larval feeding behavior (sensu Insecta)
namespace: biological_process
def: "OBSOLETE. Feeding behavior in an insect larva." [GOC:jid, GOC:mah]
comment: This term was made obsolete because there is no clear difference between the sensu Drosophila term and the generic term.
synonym: "larval feeding behavior (sensu Insecta)" EXACT []
is_obsolete: true
replaced_by: GO:0030536

[Term]
id: GO:0008343
name: adult feeding behavior
namespace: biological_process
def: "Feeding behavior in a fully developed and mature organism." [GOC:mah]
comment: See also the biological process term 'feeding behavior ; GO:0007631'.
synonym: "adult feeding behaviour" EXACT []
is_a: GO:0007631 ! feeding behavior
is_a: GO:0030534 ! adult behavior

[Term]
id: GO:0008344
name: adult locomotory behavior
namespace: biological_process
def: "Locomotory behavior in a fully developed and mature organism." [GOC:ai]
comment: See also the biological process term 'locomotory behavior ; GO:0007626'.
synonym: "adult locomotory behaviour" EXACT []
is_a: GO:0007626 ! locomotory behavior
is_a: GO:0030534 ! adult behavior

[Term]
id: GO:0008345
name: larval locomotory behavior
namespace: biological_process
def: "Locomotory behavior in a larval (immature) organism." [GOC:ai]
comment: See also the biological process term 'locomotory behavior ; GO:0007626'.
synonym: "larval locomotory behaviour" EXACT []
is_a: GO:0007626 ! locomotory behavior
is_a: GO:0030537 ! larval behavior

[Term]
id: GO:0008346
name: larval walking behavior
namespace: biological_process
def: "The behavior of a larval organism relating to the progression of that organism along the ground by the process of lifting and setting down each leg." [GOC:go_curators, GOC:pr]
synonym: "larval walking behaviour" EXACT []
is_a: GO:0008345 ! larval locomotory behavior
is_a: GO:0090659 ! walking behavior

[Term]
id: GO:0008347
name: glial cell migration
namespace: biological_process
alt_id: GO:0043359
def: "The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:jl, GOC:mtg_sensu]
synonym: "glia cell migration" EXACT []
is_a: GO:0016477 ! cell migration
relationship: part_of GO:0042063 ! gliogenesis

[Term]
id: GO:0008348
name: negative regulation of antimicrobial humoral response
namespace: biological_process
alt_id: GO:0042154
alt_id: GO:0042155
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an antimicrobial humoral response." [GOC:go_curators]
synonym: "attenuation of antimicrobial humoral response" EXACT []
synonym: "down regulation of antimicrobial humoral response" EXACT []
synonym: "down-regulation of antimicrobial humoral response" EXACT []
synonym: "downregulation of antimicrobial humoral response" EXACT []
synonym: "inhibition of antimicrobial humoral response" NARROW []
is_a: GO:0002759 ! regulation of antimicrobial humoral response
is_a: GO:0002832 ! negative regulation of response to biotic stimulus
is_a: GO:0002921 ! negative regulation of humoral immune response
is_a: GO:0032102 ! negative regulation of response to external stimulus
is_a: GO:0043901 ! negative regulation of multi-organism process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019730 ! antimicrobial humoral response
relationship: negatively_regulates GO:0019730 ! antimicrobial humoral response

[Term]
id: GO:0008349
name: MAP kinase kinase kinase kinase activity
namespace: molecular_function
def: "Catalysis of the phosphorylation of serine and threonine residues in a mitogen-activated protein kinase kinase kinase (MAPKKK), resulting in activation of MAPKKK. MAPKKK signaling pathways relay, amplify and integrate signals from the plasma membrane to the nucleus in response to a diverse range of extracellular stimuli." [GOC:bf, PMID:11790549]
synonym: "MAP4K activity" EXACT [PMID:20811974]
synonym: "MAPKKKK" EXACT []
xref: EC:2.7.11.-
is_a: GO:0004702 ! receptor signaling protein serine/threonine kinase activity
relationship: part_of GO:0000165 ! MAPK cascade
relationship: part_of GO:0000185 ! activation of MAPKKK activity

[Term]
id: GO:0008350
name: obsolete kinetochore motor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it includes cellular component information.
synonym: "kinetochore motor activity" EXACT []
is_obsolete: true
consider: GO:0000776
consider: GO:0003777

[Term]
id: GO:0008351
name: obsolete microtubule severing activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it describes a biological process.
synonym: "microtubule severing activity" EXACT []
is_obsolete: true
consider: GO:0008017
consider: GO:0051013

[Term]
id: GO:0008352
name: katanin complex
namespace: cellular_component
def: "A complex possessing an activity that couples ATP hydrolysis to the severing of microtubules; usually a heterodimer comprising a catalytic subunit (often 60kDa) and a regulatory subunit (often 80 kDa)." [PMID:10910766]
comment: Consider also annotating to the molecular function term 'microtubule-severing ATPase activity ; GO:0008568'.
is_a: GO:0005875 ! microtubule associated complex
is_a: GO:0044450 ! microtubule organizing center part

[Term]
id: GO:0008353
name: RNA polymerase II carboxy-terminal domain kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + (DNA-directed RNA polymerase II) = ADP + phospho-(DNA-directed RNA polymerase II); phosphorylation occurs on residues in the carboxy-terminal domain (CTD) repeats." [EC:2.7.11.23, GOC:mah]
synonym: "[RNA-polymerase]-subunit kinase activity" BROAD []
synonym: "ATP:DNA-directed RNA polymerase phosphotransferase activity" BROAD [EC:2.7.11.23]
synonym: "CTD kinase activity" EXACT [EC:2.7.11.23]
synonym: "RNA polymerase subunit kinase activity" BROAD [EC:2.7.11.23]
synonym: "RNA-polymerase-subunit kinase activity" BROAD [EC:2.7.11.23]
synonym: "STK9" RELATED [EC:2.7.11.23]
xref: EC:2.7.11.23
xref: MetaCyc:RNA-POLYMERASE-SUBUNIT-KINASE-RXN
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0008354
name: germ cell migration
namespace: biological_process
def: "The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form." [GOC:bf, GOC:jl]
synonym: "germ-cell migration" EXACT []
synonym: "primordial germ cell migration" RELATED []
is_a: GO:0016477 ! cell migration
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
relationship: part_of GO:0007276 ! gamete generation

[Term]
id: GO:0008355
name: olfactory learning
namespace: biological_process
def: "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089]
is_a: GO:0008306 ! associative learning
is_a: GO:0042048 ! olfactory behavior

[Term]
id: GO:0008356
name: asymmetric cell division
namespace: biological_process
def: "The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity." [PMID:11672519]
synonym: "asymmetric cytokinesis" RELATED []
synonym: "asymmetrical cell division" EXACT []
synonym: "asymmetrical cytokinesis" RELATED []
xref: Wikipedia:Asymmetric_cell_division
is_a: GO:0051301 ! cell division

[Term]
id: GO:0008358
name: maternal determination of anterior/posterior axis, embryo
namespace: biological_process
def: "The specification of the anterior/posterior axis of the embryo by gradients of maternally-transcribed gene products; exemplified in insects by the morphogens, bicoid and nanos." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
is_a: GO:0008595 ! anterior/posterior axis specification, embryo

[Term]
id: GO:0008359
name: regulation of bicoid mRNA localization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the process in which bicoid mRNA is transported to, or maintained in, a specific location." [GOC:hb]
synonym: "regulation of bicoid mRNA localisation" EXACT [GOC:mah]
is_a: GO:0060281 ! regulation of oocyte development
is_a: GO:1902875 ! regulation of embryonic pattern specification
is_a: GO:1903429 ! regulation of cell maturation
is_a: GO:1904580 ! regulation of intracellular mRNA localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045450 ! bicoid mRNA localization
relationship: regulates GO:0045450 ! bicoid mRNA localization

[Term]
id: GO:0008360
name: regulation of cell shape
namespace: biological_process
alt_id: GO:0045788
alt_id: GO:0045789
def: "Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
subset: gosubset_prok
is_a: GO:0022604 ! regulation of cell morphogenesis
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0008361
name: regulation of cell size
namespace: biological_process
def: "Any process that modulates the size of a cell." [GOC:go_curators]
subset: gosubset_prok
synonym: "cell size control" EXACT []
is_a: GO:0032535 ! regulation of cellular component size

[Term]
id: GO:0008362
name: chitin-based embryonic cuticle biosynthetic process
namespace: biological_process
def: "Synthesis, including the chemical reactions and pathways resulting in the formation of chitin and other components, and deposition of a chitin-based embryonic cuticle by the underlying epidermal epithelium. This tough, waterproof cuticle layer is essential to provide structural integrity of the larval body. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12019232]
synonym: "embryonic cuticle anabolism" BROAD []
synonym: "embryonic cuticle biosynthetic process" BROAD []
synonym: "embryonic cuticle formation" BROAD []
synonym: "embryonic cuticle synthesis" BROAD []
is_a: GO:0040003 ! chitin-based cuticle development

[Term]
id: GO:0008363
name: larval chitin-based cuticle development
namespace: biological_process
def: "Synthesis and deposition of a chitin-based larval cuticle. The insect larval cuticle is a secretion from epidermal cells that is shed at each molt. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238]
synonym: "larval cuticle anabolism" BROAD []
synonym: "larval cuticle biosynthetic process" BROAD []
synonym: "larval cuticle formation" BROAD []
synonym: "larval cuticle synthesis" BROAD []
is_a: GO:0042337 ! cuticle development involved in chitin-based cuticle molting cycle
relationship: part_of GO:0002168 ! instar larval development

[Term]
id: GO:0008364
name: pupal chitin-based cuticle development
namespace: biological_process
def: "Synthesis and deposition of a chitin-based pupal cuticle. At the end of the prepupal period the insect is covered by the pupal cuticle which continues to be elaborated into the pupal period. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238]
synonym: "pupal cuticle anabolism" BROAD []
synonym: "pupal cuticle formation" BROAD []
synonym: "pupal cuticle synthesis" BROAD []
is_a: GO:0042337 ! cuticle development involved in chitin-based cuticle molting cycle
relationship: part_of GO:0035209 ! pupal development

[Term]
id: GO:0008365
name: adult chitin-based cuticle development
namespace: biological_process
def: "Synthesis and deposition of the chitin-based cuticle of adults following the apolysis of the pupal cuticle. The adult insect cuticle contains cuticullin, a protein epicuticle and a lamellate procuticle. An example of this process is adult chitin-based cuticle development in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238]
synonym: "adult chitin-based cuticle anabolism" EXACT []
synonym: "adult chitin-based cuticle biosynthetic process" EXACT []
synonym: "adult chitin-based cuticle formation" EXACT []
synonym: "adult chitin-based cuticle synthesis" EXACT []
synonym: "adult cuticle anabolism" BROAD []
synonym: "adult cuticle biosynthetic process" BROAD []
synonym: "adult cuticle formation" BROAD []
synonym: "adult cuticle synthesis" BROAD []
is_a: GO:0040003 ! chitin-based cuticle development

[Term]
id: GO:0008366
name: axon ensheathment
namespace: biological_process
alt_id: GO:0042553
def: "Any process in which the axon of a neuron is insulated, and that insulation maintained, thereby preventing dispersion of the electrical signal." [GOC:jl, ISBN:0878932437]
synonym: "cellular axon ensheathment" EXACT []
synonym: "cellular nerve ensheathment" RELATED []
synonym: "nerve ensheathment" RELATED []
is_a: GO:0007272 ! ensheathment of neurons

[Term]
id: GO:0008369
name: obsolete molecular function
namespace: molecular_function
def: "OBSOLETE. These are terms that have been removed from the active function ontology." [GOC:go_curators]
comment: This term was made obsolete because it is unnecessary in the OBO flat file format.
is_obsolete: true

[Term]
id: GO:0008370
name: obsolete cellular component
namespace: cellular_component
def: "OBSOLETE. These are terms that have been removed from the active component ontology." [GOC:go_curators]
comment: This term was made obsolete because it is unnecessary in the OBO flat file format.
is_obsolete: true

[Term]
id: GO:0008371
name: obsolete biological process
namespace: biological_process
def: "OBSOLETE. These are terms that have been removed from the active process ontology." [GOC:go_curators]
comment: This term was made obsolete because it is unnecessary in the OBO flat file format.
is_obsolete: true

[Term]
id: GO:0008373
name: sialyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of sialic acid to an acceptor molecule, typically the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins." [EC:2.4.99, GOC:cjm, Wikipedia:Sialyltransferase]
xref: EC:2.4.99.-
xref: Reactome:REACT_115996 "GalNAc alpha-2,6-sialyltransferase II can add a sialic acid to the T antigen at the alpha 6 position, Homo sapiens"
is_a: GO:0016757 ! transferase activity, transferring glycosyl groups
relationship: part_of GO:0097503 ! sialylation

[Term]
id: GO:0008374
name: O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule." [GOC:ai]
subset: gosubset_prok
xref: EC:2.3.1.-
xref: Reactome:REACT_1049 "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH, Homo sapiens"
xref: Reactome:REACT_105946 "Decanoylation of Proghrelin by Ghrelin O-acyltransferase, Mus musculus"
xref: Reactome:REACT_107115 "Decanoylation of Proghrelin by Ghrelin O-acyltransferase, Sus scrofa"
xref: Reactome:REACT_110232 "Decanoylation of Proghrelin by Ghrelin O-acyltransferase, Bos taurus"
xref: Reactome:REACT_19318 "Octanoylation of Proghrelin by Ghrelin O-acyltransferase, Homo sapiens"
xref: Reactome:REACT_19329 "Decanoylation of Proghrelin by Ghrelin O-acyltransferase, Homo sapiens"
xref: Reactome:REACT_29061 "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH, Taeniopygia guttata"
xref: Reactome:REACT_30439 "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH, Xenopus tropicalis"
xref: Reactome:REACT_31331 "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH, Plasmodium falciparum"
xref: Reactome:REACT_32115 "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH, Arabidopsis thaliana"
xref: Reactome:REACT_34533 "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH, Oryza sativa"
xref: Reactome:REACT_77281 "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH, Dictyostelium discoideum"
xref: Reactome:REACT_78185 "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH, Caenorhabditis elegans"
xref: Reactome:REACT_78639 "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH, Saccharomyces cerevisiae"
xref: Reactome:REACT_78935 "Octanoylation of Proghrelin by Ghrelin O-acyltransferase, Rattus norvegicus"
xref: Reactome:REACT_79019 "Decanoylation of Proghrelin by Ghrelin O-acyltransferase, Rattus norvegicus"
xref: Reactome:REACT_81373 "Decanoylation of Proghrelin by Ghrelin O-acyltransferase, Gallus gallus"
xref: Reactome:REACT_84839 "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH, Gallus gallus"
xref: Reactome:REACT_85627 "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH, Rattus norvegicus"
xref: Reactome:REACT_85903 "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH, Canis familiaris"
xref: Reactome:REACT_86966 "Octanoylation of Proghrelin by Ghrelin O-acyltransferase, Mus musculus"
xref: Reactome:REACT_88670 "Octanoylation of Proghrelin by Ghrelin O-acyltransferase, Sus scrofa"
xref: Reactome:REACT_90799 "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH, Sus scrofa"
xref: Reactome:REACT_92055 "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH, Bos taurus"
xref: Reactome:REACT_92710 "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH, Danio rerio"
xref: Reactome:REACT_94821 "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH, Drosophila melanogaster"
xref: Reactome:REACT_95245 "Octanoylation of Proghrelin by Ghrelin O-acyltransferase, Gallus gallus"
xref: Reactome:REACT_96091 "Octanoylation of Proghrelin by Ghrelin O-acyltransferase, Bos taurus"
xref: Reactome:REACT_96263 "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH, Mus musculus"
xref: Reactome:REACT_97470 "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH, Schizosaccharomyces pombe"
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0008375
name: acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732]
subset: gosubset_prok
synonym: "GlcNAc transferase activity" EXACT []
xref: EC:2.4.1.-
xref: MetaCyc:2.4.1.223-RXN
xref: Reactome:REACT_27245 "acetylglucosamine is transferred from UDP-GlcNAc onto inositol-1-phosphate, Mycobacterium tuberculosis"
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0008376
name: acetylgalactosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide." [ISBN:0198506732]
synonym: "GalNAc transferase activity" EXACT []
xref: EC:2.4.1.-
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0008377
name: light-induced release of internally sequestered calcium ion
namespace: biological_process
def: "The process in which the detection of light triggers the release of internally sequestered calcium ions." [GOC:ai]
synonym: "light-induced release of calcium from internal store" EXACT []
synonym: "light-induced release of internally sequestered calcium ion (Ca2+)" EXACT []
synonym: "light-induced release of internally stored calcium ion (Ca2+)" EXACT []
is_a: GO:0051283 ! negative regulation of sequestering of calcium ion
relationship: part_of GO:0016056 ! rhodopsin mediated signaling pathway

[Term]
id: GO:0008378
name: galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [ISBN:0198506732]
subset: gosubset_prok
xref: EC:2.4.1.-
xref: MetaCyc:2.4.1.151-RXN
xref: Reactome:REACT_116069 "Addition of galactose to Core 6 glycoprotein, Homo sapiens"
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0008379
name: thioredoxin peroxidase activity
namespace: molecular_function
alt_id: GO:0009031
def: "Catalysis of the reaction: thioredoxin + hydrogen peroxide = thioredoxin disulfide + H2O." [MetaCyc:RXN0-267]
subset: gosubset_prok
synonym: "thiol peroxidase activity" EXACT []
synonym: "TPx activity" EXACT []
synonym: "TrxPx activity" EXACT []
xref: EC:1.11.1.-
xref: MetaCyc:RXN0-267
is_a: GO:0004601 ! peroxidase activity
is_a: GO:0051920 ! peroxiredoxin activity

[Term]
id: GO:0008380
name: RNA splicing
namespace: biological_process
alt_id: GO:0006395
def: "The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:krc, GOC:mah]
subset: goslim_yeast
subset: gosubset_prok
synonym: "pre-mRNA splicing factor activity" RELATED []
xref: Reactome:REACT_107090 "mRNA Splicing, Gallus gallus"
xref: Reactome:REACT_107348 "mRNA Splicing, Dictyostelium discoideum"
xref: Reactome:REACT_107931 "mRNA Splicing, Caenorhabditis elegans"
xref: Reactome:REACT_108122 "mRNA Splicing, Schizosaccharomyces pombe"
xref: Reactome:REACT_113880 "mRNA Splicing, Taeniopygia guttata"
xref: Reactome:REACT_1735 "mRNA Splicing, Homo sapiens"
xref: Reactome:REACT_34200 "mRNA Splicing, Plasmodium falciparum"
xref: Reactome:REACT_81581 "mRNA Splicing, Oryza sativa"
xref: Reactome:REACT_82520 "mRNA Splicing, Rattus norvegicus"
xref: Reactome:REACT_91201 "mRNA Splicing, Canis familiaris"
xref: Reactome:REACT_94469 "mRNA Splicing, Drosophila melanogaster"
xref: Reactome:REACT_96521 "mRNA Splicing, Bos taurus"
xref: Reactome:REACT_97651 "mRNA Splicing, Xenopus tropicalis"
xref: Reactome:REACT_98240 "mRNA Splicing, Danio rerio"
xref: Reactome:REACT_98753 "mRNA Splicing, Mus musculus"
xref: Reactome:REACT_98879 "mRNA Splicing, Arabidopsis thaliana"
xref: Wikipedia:RNA_splicing
is_a: GO:0006396 ! RNA processing

[Term]
id: GO:0008381
name: mechanically-gated ion channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of an ion by a channel that opens in response to a mechanical stress." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0005216 ! ion channel activity
is_a: GO:0022833 ! mechanically gated channel activity

[Term]
id: GO:0008384
name: IkappaB kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + IkappaB protein = ADP + IkappaB phosphoprotein." [EC:2.7.11.10]
comment: Note that phosphorylation of IkappaB targets it for proteasomal degradation and allows the nuclear translocation of kB.
synonym: "ATP:IkappaB protein phosphotransferase activity" EXACT [EC:2.7.11.10]
synonym: "CHUK" RELATED [EC:2.7.11.10]
synonym: "ikappaB kinase activity" EXACT [EC:2.7.11.10]
synonym: "IKBKA" RELATED [EC:2.7.11.10]
synonym: "IKBKB" RELATED [EC:2.7.11.10]
synonym: "IKK" RELATED [EC:2.7.11.10]
synonym: "IKK-1" RELATED [EC:2.7.11.10]
synonym: "IKK-2" RELATED [EC:2.7.11.10]
synonym: "inhibitor of NF-kappaB kinase activity" EXACT [EC:2.7.11.10]
synonym: "inhibitor of NFkappaB kinase activity" EXACT [EC:2.7.11.10]
synonym: "STK12" RELATED [EC:2.7.11.10]
synonym: "TANK-binding kinase 1 activity" NARROW [EC:2.7.11.10]
synonym: "TBK1" RELATED [EC:2.7.11.10]
xref: EC:2.7.11.10
xref: MetaCyc:2.7.11.10-RXN
xref: Reactome:REACT_22418 "The IKKB complex phosphorylates NFkB p105, Homo sapiens"
is_a: GO:0004674 ! protein serine/threonine kinase activity
is_a: GO:0005057 ! receptor signaling protein activity
relationship: part_of GO:0007252 ! I-kappaB phosphorylation

[Term]
id: GO:0008385
name: IkappaB kinase complex
namespace: cellular_component
def: "A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription." [GOC:bf, GOC:ma, PMID:12055104, PMID:20300203]
synonym: "heterotrimeric IKK complex" EXACT [GOC:bf]
synonym: "IKK complex" EXACT []
synonym: "trimeric IKK complex" EXACT [PMID:21173796]
is_a: GO:0044445 ! cytosolic part
is_a: GO:1902554 ! serine/threonine protein kinase complex

[Term]
id: GO:0008386
name: cholesterol monooxygenase (side-chain-cleaving) activity
namespace: molecular_function
def: "Catalysis of the reaction: cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O." [EC:1.14.15.6]
synonym: "C27-side chain cleavage enzyme" RELATED [EC:1.14.15.6]
synonym: "cholesterol 20-22-desmolase activity" EXACT [EC:1.14.15.6]
synonym: "cholesterol C(20-22) desmolase activity" EXACT [EC:1.14.15.6]
synonym: "cholesterol C20-22 desmolase activity" EXACT [EC:1.14.15.6]
synonym: "cholesterol desmolase activity" EXACT [EC:1.14.15.6]
synonym: "cholesterol side-chain cleavage enzyme activity" RELATED [EC:1.14.15.6]
synonym: "cholesterol side-chain-cleaving enzyme activity" RELATED [EC:1.14.15.6]
synonym: "cholesterol,reduced-adrenal-ferredoxin:oxygen oxidoreductase (side-chain-cleaving)" EXACT [EC:1.14.15.6]
synonym: "Cyp11a1" NARROW []
synonym: "cytochrome P-450(scc) activity" NARROW [EC:1.14.15.6]
synonym: "cytochrome P-450scc" RELATED [EC:1.14.15.6]
synonym: "cytochrome p450(scc) activity" NARROW [EC:1.14.15.6]
synonym: "cytochrome p450scc" RELATED [EC:1.14.15.6]
synonym: "desmolase, steroid 20-22" EXACT [EC:1.14.15.6]
synonym: "enzymes, cholesterol side-chain-cleaving" RELATED [EC:1.14.15.6]
synonym: "steroid 20-22 desmolase activity" BROAD [EC:1.14.15.6]
synonym: "steroid 20-22-lyase activity" BROAD [EC:1.14.15.6]
xref: EC:1.14.15.6
xref: MetaCyc:1.14.15.6-RXN
xref: Reactome:REACT_10035 "20alpha,22beta-hydroxycholesterol is cleaved by CYP11A1 to yield pregnenolone and isocaproaldehyde, Homo sapiens"
xref: Reactome:REACT_10084 "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol, Homo sapiens"
xref: Reactome:REACT_101443 "Oxidation of cholesterol to 22beta-hydroxycholesterol, Xenopus tropicalis"
xref: Reactome:REACT_101702 "Oxidation of cholesterol to 22beta-hydroxycholesterol, Canis familiaris"
xref: Reactome:REACT_102228 "20alpha,22beta-hydroxycholesterol is cleaved by CYP11A1 to yield pregnenolone and isocaproaldehyde, Canis familiaris"
xref: Reactome:REACT_102567 "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol, Mus musculus"
xref: Reactome:REACT_103083 "20alpha,22beta-hydroxycholesterol is cleaved by CYP11A1 to yield pregnenolone and isocaproaldehyde, Mus musculus"
xref: Reactome:REACT_105259 "Oxidation of cholesterol to 22beta-hydroxycholesterol, Gallus gallus"
xref: Reactome:REACT_106318 "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol, Bos taurus"
xref: Reactome:REACT_108193 "Oxidation of cholesterol to 22beta-hydroxycholesterol, Bos taurus"
xref: Reactome:REACT_109534 "Oxidation of cholesterol to 22beta-hydroxycholesterol, Danio rerio"
xref: Reactome:REACT_109733 "20alpha,22beta-hydroxycholesterol is cleaved by CYP11A1 to yield pregnenolone and isocaproaldehyde, Rattus norvegicus"
xref: Reactome:REACT_109882 "Oxidation of cholesterol to 22beta-hydroxycholesterol, Drosophila melanogaster"
xref: Reactome:REACT_65089 "20alpha,22beta-hydroxycholesterol is cleaved by CYP11A1 to yield pregnenolone and isocaproaldehyde, Bos taurus"
xref: Reactome:REACT_81340 "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol, Danio rerio"
xref: Reactome:REACT_82060 "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol, Canis familiaris"
xref: Reactome:REACT_82162 "20alpha,22beta-hydroxycholesterol is cleaved by CYP11A1 to yield pregnenolone and isocaproaldehyde, Taeniopygia guttata"
xref: Reactome:REACT_83052 "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol, Xenopus tropicalis"
xref: Reactome:REACT_83084 "Oxidation of cholesterol to 22beta-hydroxycholesterol, Mus musculus"
xref: Reactome:REACT_83609 "20alpha,22beta-hydroxycholesterol is cleaved by CYP11A1 to yield pregnenolone and isocaproaldehyde, Gallus gallus"
xref: Reactome:REACT_83756 "20alpha,22beta-hydroxycholesterol is cleaved by CYP11A1 to yield pregnenolone and isocaproaldehyde, Xenopus tropicalis"
xref: Reactome:REACT_85511 "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol, Rattus norvegicus"
xref: Reactome:REACT_87922 "20alpha,22beta-hydroxycholesterol is cleaved by CYP11A1 to yield pregnenolone and isocaproaldehyde, Drosophila melanogaster"
xref: Reactome:REACT_88900 "Oxidation of cholesterol to 22beta-hydroxycholesterol, Rattus norvegicus"
xref: Reactome:REACT_89556 "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol, Drosophila melanogaster"
xref: Reactome:REACT_90435 "20alpha,22beta-hydroxycholesterol is cleaved by CYP11A1 to yield pregnenolone and isocaproaldehyde, Danio rerio"
xref: Reactome:REACT_92023 "Oxidation of cholesterol to 22beta-hydroxycholesterol, Taeniopygia guttata"
xref: Reactome:REACT_94232 "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol, Gallus gallus"
xref: Reactome:REACT_94560 "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol, Taeniopygia guttata"
xref: Reactome:REACT_9956 "Oxidation of cholesterol to 22beta-hydroxycholesterol, Homo sapiens"
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0008387
name: steroid 7-alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: a steroid + donor-H2 + O2 = 7-alpha-hydroxysteroid + H2O." [GOC:mah]
synonym: "cytochrome P450 CYP2A12" NARROW []
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0008388
name: testosterone 15-alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: testosterone + donor-H2 + O2 = 15-alpha-hydroxytestosterone + H2O." [GOC:ai]
synonym: "cytochrome P450 CYP2A4" NARROW []
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0008389
name: coumarin 7-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: coumarin + O2 + NADPH + H+ = hydroxycoumarin + H2O + NADP+." [Reactome:163103]
synonym: "cytochrome P450 CYP2A5" NARROW []
xref: Reactome:REACT_112622 "Coumarin is 7-hydroxylated by CYP2A6, Xenopus tropicalis"
xref: Reactome:REACT_112822 "Coumarin is 7-hydroxylated by CYP2A6, Danio rerio"
xref: Reactome:REACT_113359 "Coumarin is 7-hydroxylated by CYP2A6, Mus musculus"
xref: Reactome:REACT_113450 "Coumarin is 7-hydroxylated by CYP2A6, Rattus norvegicus"
xref: Reactome:REACT_13492 "Coumarin is 7-hydroxylated by CYP2A13, Homo sapiens"
xref: Reactome:REACT_572 "Coumarin is 7-hydroxylated by CYP2A6, Homo sapiens"
xref: Reactome:REACT_80565 "Coumarin is 7-hydroxylated by CYP2A13, Rattus norvegicus"
xref: Reactome:REACT_83154 "Coumarin is 7-hydroxylated by CYP2A13, Xenopus tropicalis"
xref: Reactome:REACT_83496 "Coumarin is 7-hydroxylated by CYP2A13, Mus musculus"
xref: Reactome:REACT_91477 "Coumarin is 7-hydroxylated by CYP2A13, Danio rerio"
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0008390
name: testosterone 16-alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: testosterone + donor-H2 + O2 = 6-alpha-hydroxytestosterone + H2O." [GOC:ai]
synonym: "cytochrome P450 CYP2B10" NARROW []
synonym: "cytochrome P450 CYP2B9" NARROW []
synonym: "cytochrome P450 CYP2D10" NARROW []
synonym: "cytochrome P450 CYP2D11" NARROW []
synonym: "cytochrome P450 CYP2D9" NARROW []
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0008391
name: arachidonic acid monooxygenase activity
namespace: molecular_function
def: "Catalysis of the incorporation of one atom from molecular oxygen into arachidonic acid and the reduction of the other atom of oxygen to water." [GOC:mah]
synonym: "cytochrome P450 CYP2B19" NARROW []
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0008392
name: arachidonic acid epoxygenase activity
namespace: molecular_function
def: "Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to a cis-epoxyeicosatrienoic acid." [http://lipidlibrary.aocs.org/Lipids/eic_hete/index.htm, PMID:10681399]
synonym: "cytochrome P450 CYP2J5" NARROW []
synonym: "cytochrome P450 CYP2J6" NARROW []
xref: Reactome:REACT_104862 "CYP2J2 epoxygenates arachidonic acid, Gallus gallus"
xref: Reactome:REACT_13525 "CYP2J2 epoxygenates arachidonic acid, Homo sapiens"
xref: Reactome:REACT_30227 "CYP2J2 epoxygenates arachidonic acid, Canis familiaris"
xref: Reactome:REACT_33796 "CYP2J2 epoxygenates arachidonic acid, Danio rerio"
xref: Reactome:REACT_76977 "CYP2J2 epoxygenates arachidonic acid, Xenopus tropicalis"
xref: Reactome:REACT_83097 "CYP2J2 epoxygenates arachidonic acid, Bos taurus"
xref: Reactome:REACT_90504 "CYP2J2 epoxygenates arachidonic acid, Mus musculus"
xref: Reactome:REACT_91810 "CYP2J2 epoxygenates arachidonic acid, Sus scrofa"
xref: Reactome:REACT_97618 "CYP2J2 epoxygenates arachidonic acid, Rattus norvegicus"
xref: Reactome:REACT_99323 "CYP2J2 epoxygenates arachidonic acid, Taeniopygia guttata"
is_a: GO:0008391 ! arachidonic acid monooxygenase activity

[Term]
id: GO:0008395
name: steroid hydroxylase activity
namespace: molecular_function
alt_id: GO:0008394
def: "Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2." [ISBN:0721662544]
synonym: "cytochrome P450 CYP2G1" NARROW []
synonym: "olfactory-specific steroid hydroxylase activity" NARROW []
xref: Reactome:REACT_10001 "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA), Homo sapiens"
xref: Reactome:REACT_10005 "3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA), Homo sapiens"
xref: Reactome:REACT_10009 "5beta-cholestan-3alpha, 7alpha, 12alpha-triol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 12alpha, 27-tetrol, Homo sapiens"
xref: Reactome:REACT_100116 "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al, Canis familiaris"
xref: Reactome:REACT_10025 "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al, Homo sapiens"
xref: Reactome:REACT_100285 "Androstenedione is converted to estrone by Aromatase (CYP19A1), Gallus gallus"
xref: Reactome:REACT_10030 "Cholesterol is hydroxylated to 25-hydroxycholesterol, Homo sapiens"
xref: Reactome:REACT_10042 "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al, Homo sapiens"
xref: Reactome:REACT_100427 "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA), Sus scrofa"
xref: Reactome:REACT_10045 "Hydroxylation of corticosterone to form 18-hydroxycorticosterone, Homo sapiens"
xref: Reactome:REACT_100488 "Cholesterol is hydroxylated to 25-hydroxycholesterol, Taeniopygia guttata"
xref: Reactome:REACT_100597 "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA), Mus musculus"
xref: Reactome:REACT_100715 "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al, Taeniopygia guttata"
xref: Reactome:REACT_10075 "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol, Homo sapiens"
xref: Reactome:REACT_100889 "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol, Drosophila melanogaster"
xref: Reactome:REACT_10094 "Conversion of 18-hydroxycorticosterone to aldosterone, Homo sapiens"
xref: Reactome:REACT_10096 "5beta-cholestan-3alpha,7alpha,24(S)-triol is hydroxylated to 5beta-cholestan-3alpha,7alpha,24(S), 27-tetrol, Homo sapiens"
xref: Reactome:REACT_10100 "3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA), Homo sapiens"
xref: Reactome:REACT_10104 "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol, Homo sapiens"
xref: Reactome:REACT_101057 "Conversion of 18-hydroxycorticosterone to aldosterone, Drosophila melanogaster"
xref: Reactome:REACT_101133 "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA), Bos taurus"
xref: Reactome:REACT_101160 "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA), Rattus norvegicus"
xref: Reactome:REACT_101405 "Androstenedione is converted to estrone by Aromatase (CYP19A1), Danio rerio"
xref: Reactome:REACT_101457 "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol, Taeniopygia guttata"
xref: Reactome:REACT_102249 "Conversion of 18-hydroxycorticosterone to aldosterone, Danio rerio"
xref: Reactome:REACT_102270 "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al, Mus musculus"
xref: Reactome:REACT_102482 "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol, Danio rerio"
xref: Reactome:REACT_102970 "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol, Taeniopygia guttata"
xref: Reactome:REACT_103013 "Cholesterol is hydroxylated to 25-hydroxycholesterol, Bos taurus"
xref: Reactome:REACT_103172 "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al, Bos taurus"
xref: Reactome:REACT_103406 "Testosterone is converted to estradiol, Taeniopygia guttata"
xref: Reactome:REACT_103473 "Cholesterol is hydroxylated to 27-hydroxycholesterol by CYP27, Drosophila melanogaster"
xref: Reactome:REACT_103572 "5beta-cholestan-3alpha,7alpha,24(S)-triol is hydroxylated to 5beta-cholestan-3alpha,7alpha,24(S), 27-tetrol, Drosophila melanogaster"
xref: Reactome:REACT_103665 "Conversion of 18-hydroxycorticosterone to aldosterone, Canis familiaris"
xref: Reactome:REACT_103764 "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al, Xenopus tropicalis"
xref: Reactome:REACT_103898 "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA), Xenopus tropicalis"
xref: Reactome:REACT_104743 "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al, Xenopus tropicalis"
xref: Reactome:REACT_104907 "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al, Danio rerio"
xref: Reactome:REACT_105119 "3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA), Danio rerio"
xref: Reactome:REACT_105122 "Androstenedione is converted to estrone by Aromatase (CYP19A1), Mus musculus"
xref: Reactome:REACT_105574 "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol, Canis familiaris"
xref: Reactome:REACT_105647 "Cholesterol is hydroxylated to 25-hydroxycholesterol, Gallus gallus"
xref: Reactome:REACT_105658 "Hydroxylation of corticosterone to form 18-hydroxycorticosterone, Bos taurus"
xref: Reactome:REACT_106119 "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA), Drosophila melanogaster"
xref: Reactome:REACT_106175 "Cholesterol is hydroxylated to 27-hydroxycholesterol by CYP27, Rattus norvegicus"
xref: Reactome:REACT_106264 "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al, Canis familiaris"
xref: Reactome:REACT_106299 "Cholesterol is hydroxylated to 25-hydroxycholesterol, Saccharomyces cerevisiae"
xref: Reactome:REACT_106743 "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al, Taeniopygia guttata"
xref: Reactome:REACT_106827 "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA), Drosophila melanogaster"
xref: Reactome:REACT_106925 "Conversion of 18-hydroxycorticosterone to aldosterone, Bos taurus"
xref: Reactome:REACT_107097 "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al, Bos taurus"
xref: Reactome:REACT_107301 "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol, Xenopus tropicalis"
xref: Reactome:REACT_107421 "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol, Bos taurus"
xref: Reactome:REACT_107517 "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al, Canis familiaris"
xref: Reactome:REACT_107560 "Cholesterol is hydroxylated to 27-hydroxycholesterol by CYP27, Danio rerio"
xref: Reactome:REACT_107927 "Cholesterol is hydroxylated to 27-hydroxycholesterol by CYP27, Bos taurus"
xref: Reactome:REACT_108054 "5beta-cholestan-3alpha, 7alpha, 12alpha-triol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 12alpha, 27-tetrol, Taeniopygia guttata"
xref: Reactome:REACT_108167 "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al, Rattus norvegicus"
xref: Reactome:REACT_108262 "5beta-cholestan-3alpha, 7alpha, 12alpha-triol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 12alpha, 27-tetrol, Mus musculus"
xref: Reactome:REACT_108352 "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al, Mus musculus"
xref: Reactome:REACT_108506 "Testosterone is converted to estradiol, Danio rerio"
xref: Reactome:REACT_108715 "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol, Gallus gallus"
xref: Reactome:REACT_109508 "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al, Mus musculus"
xref: Reactome:REACT_109662 "Hydroxylation of corticosterone to form 18-hydroxycorticosterone, Canis familiaris"
xref: Reactome:REACT_109913 "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA), Bos taurus"
xref: Reactome:REACT_109958 "Androstenedione is converted to estrone by Aromatase (CYP19A1), Canis familiaris"
xref: Reactome:REACT_110648 "5beta-cholestan-3alpha, 7alpha, 12alpha-triol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 12alpha, 27-tetrol, Gallus gallus"
xref: Reactome:REACT_110792 "Cholesterol is hydroxylated to 27-hydroxycholesterol by CYP27, Xenopus tropicalis"
xref: Reactome:REACT_110924 "3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA), Drosophila melanogaster"
xref: Reactome:REACT_110927 "Testosterone is converted to estradiol, Mus musculus"
xref: Reactome:REACT_112201 "Cholesterol is hydroxylated to 25-hydroxycholesterol, Xenopus tropicalis"
xref: Reactome:REACT_28470 "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol, Gallus gallus"
xref: Reactome:REACT_28483 "Cholesterol is hydroxylated to 25-hydroxycholesterol, Rattus norvegicus"
xref: Reactome:REACT_28566 "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA), Gallus gallus"
xref: Reactome:REACT_28778 "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol, Sus scrofa"
xref: Reactome:REACT_28783 "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol, Canis familiaris"
xref: Reactome:REACT_30203 "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al, Sus scrofa"
xref: Reactome:REACT_30222 "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol, Rattus norvegicus"
xref: Reactome:REACT_30627 "Hydroxylation of corticosterone to form 18-hydroxycorticosterone, Drosophila melanogaster"
xref: Reactome:REACT_30970 "3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA), Rattus norvegicus"
xref: Reactome:REACT_31111 "3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA), Mus musculus"
xref: Reactome:REACT_31116 "Androstenedione is converted to estrone by Aromatase (CYP19A1), Bos taurus"
xref: Reactome:REACT_31894 "5beta-cholestan-3alpha, 7alpha, 12alpha-triol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 12alpha, 27-tetrol, Danio rerio"
xref: Reactome:REACT_31918 "5beta-cholestan-3alpha,7alpha,24(S)-triol is hydroxylated to 5beta-cholestan-3alpha,7alpha,24(S), 27-tetrol, Taeniopygia guttata"
xref: Reactome:REACT_32094 "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al, Bos taurus"
xref: Reactome:REACT_32865 "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA), Rattus norvegicus"
xref: Reactome:REACT_33161 "Cholesterol is hydroxylated to 27-hydroxycholesterol by CYP27, Canis familiaris"
xref: Reactome:REACT_33735 "5beta-cholestan-3alpha, 7alpha, 12alpha-triol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 12alpha, 27-tetrol, Bos taurus"
xref: Reactome:REACT_33866 "3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA), Danio rerio"
xref: Reactome:REACT_34005 "Androstenedione is converted to estrone by Aromatase (CYP19A1), Rattus norvegicus"
xref: Reactome:REACT_34352 "3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA), Drosophila melanogaster"
xref: Reactome:REACT_34399 "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA), Gallus gallus"
xref: Reactome:REACT_34694 "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al, Drosophila melanogaster"
xref: Reactome:REACT_44710 "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al, Gallus gallus"
xref: Reactome:REACT_77190 "5beta-cholestan-3alpha,7alpha,24(S)-triol is hydroxylated to 5beta-cholestan-3alpha,7alpha,24(S), 27-tetrol, Rattus norvegicus"
xref: Reactome:REACT_77722 "Cholesterol is hydroxylated to 25-hydroxycholesterol, Danio rerio"
xref: Reactome:REACT_77780 "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al, Gallus gallus"
xref: Reactome:REACT_78736 "Cholesterol is hydroxylated to 27-hydroxycholesterol by CYP27, Sus scrofa"
xref: Reactome:REACT_79185 "5beta-cholestan-3alpha, 7alpha, 12alpha-triol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 12alpha, 27-tetrol, Drosophila melanogaster"
xref: Reactome:REACT_79412 "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA), Taeniopygia guttata"
xref: Reactome:REACT_79414 "Testosterone is converted to estradiol, Gallus gallus"
xref: Reactome:REACT_79962 "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol, Danio rerio"
xref: Reactome:REACT_80278 "5beta-cholestan-3alpha, 7alpha, 12alpha-triol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 12alpha, 27-tetrol, Sus scrofa"
xref: Reactome:REACT_80421 "Cholesterol is hydroxylated to 25-hydroxycholesterol, Canis familiaris"
xref: Reactome:REACT_80947 "Cholesterol is hydroxylated to 25-hydroxycholesterol, Oryza sativa"
xref: Reactome:REACT_80966 "3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA), Mus musculus"
xref: Reactome:REACT_81040 "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol, Mus musculus"
xref: Reactome:REACT_81138 "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol, Xenopus tropicalis"
xref: Reactome:REACT_81869 "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA), Danio rerio"
xref: Reactome:REACT_82531 "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA), Sus scrofa"
xref: Reactome:REACT_82915 "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al, Xenopus tropicalis"
xref: Reactome:REACT_84035 "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al, Drosophila melanogaster"
xref: Reactome:REACT_84099 "3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA), Sus scrofa"
xref: Reactome:REACT_84232 "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al, Sus scrofa"
xref: Reactome:REACT_84571 "Cholesterol is hydroxylated to 27-hydroxycholesterol by CYP27, Taeniopygia guttata"
xref: Reactome:REACT_84606 "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al, Canis familiaris"
xref: Reactome:REACT_85685 "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al, Xenopus tropicalis"
xref: Reactome:REACT_85705 "5beta-cholestan-3alpha, 7alpha, 12alpha-triol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 12alpha, 27-tetrol, Canis familiaris"
xref: Reactome:REACT_85992 "Cholesterol is hydroxylated to 27-hydroxycholesterol by CYP27, Mus musculus"
xref: Reactome:REACT_86059 "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol, Sus scrofa"
xref: Reactome:REACT_86095 "5beta-cholestan-3alpha, 7alpha, 12alpha-triol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 12alpha, 27-tetrol, Rattus norvegicus"
xref: Reactome:REACT_86361 "3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA), Xenopus tropicalis"
xref: Reactome:REACT_86478 "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al, Rattus norvegicus"
xref: Reactome:REACT_86587 "Hydroxylation of corticosterone to form 18-hydroxycorticosterone, Mus musculus"
xref: Reactome:REACT_87074 "Cholesterol is hydroxylated to 25-hydroxycholesterol, Schizosaccharomyces pombe"
xref: Reactome:REACT_87304 "Testosterone is converted to estradiol, Bos taurus"
xref: Reactome:REACT_87395 "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA), Xenopus tropicalis"
xref: Reactome:REACT_87781 "3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA), Bos taurus"
xref: Reactome:REACT_87809 "Cholesterol is hydroxylated to 25-hydroxycholesterol, Caenorhabditis elegans"
xref: Reactome:REACT_87863 "3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA), Canis familiaris"
xref: Reactome:REACT_87918 "5beta-cholestan-3alpha,7alpha,24(S)-triol is hydroxylated to 5beta-cholestan-3alpha,7alpha,24(S), 27-tetrol, Mus musculus"
xref: Reactome:REACT_88151 "3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA), Taeniopygia guttata"
xref: Reactome:REACT_88389 "5beta-cholestan-3alpha,7alpha,24(S)-triol is hydroxylated to 5beta-cholestan-3alpha,7alpha,24(S), 27-tetrol, Xenopus tropicalis"
xref: Reactome:REACT_88787 "3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA), Bos taurus"
xref: Reactome:REACT_88943 "5beta-cholestan-3alpha,7alpha,24(S)-triol is hydroxylated to 5beta-cholestan-3alpha,7alpha,24(S), 27-tetrol, Bos taurus"
xref: Reactome:REACT_89052 "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA), Canis familiaris"
xref: Reactome:REACT_89096 "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al, Taeniopygia guttata"
xref: Reactome:REACT_89101 "5beta-cholestan-3alpha, 7alpha, 12alpha-triol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 12alpha, 27-tetrol, Xenopus tropicalis"
xref: Reactome:REACT_89367 "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol, Drosophila melanogaster"
xref: Reactome:REACT_89471 "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al, Mus musculus"
xref: Reactome:REACT_89634 "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol, Bos taurus"
xref: Reactome:REACT_89767 "3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA), Xenopus tropicalis"
xref: Reactome:REACT_89962 "3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA), Gallus gallus"
xref: Reactome:REACT_90802 "5beta-cholestan-3alpha,7alpha,24(S)-triol is hydroxylated to 5beta-cholestan-3alpha,7alpha,24(S), 27-tetrol, Canis familiaris"
xref: Reactome:REACT_91127 "Androstenedione is converted to estrone by Aromatase (CYP19A1), Xenopus tropicalis"
xref: Reactome:REACT_91262 "Cholesterol is hydroxylated to 27-hydroxycholesterol by CYP27, Gallus gallus"
xref: Reactome:REACT_91331 "5beta-cholestan-3alpha,7alpha,24(S)-triol is hydroxylated to 5beta-cholestan-3alpha,7alpha,24(S), 27-tetrol, Danio rerio"
xref: Reactome:REACT_92037 "Cholesterol is hydroxylated to 25-hydroxycholesterol, Sus scrofa"
xref: Reactome:REACT_92188 "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA), Danio rerio"
xref: Reactome:REACT_92409 "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA), Mus musculus"
xref: Reactome:REACT_92424 "Cholesterol is hydroxylated to 25-hydroxycholesterol, Arabidopsis thaliana"
xref: Reactome:REACT_92453 "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA), Taeniopygia guttata"
xref: Reactome:REACT_92676 "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al, Drosophila melanogaster"
xref: Reactome:REACT_93165 "3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA), Canis familiaris"
xref: Reactome:REACT_93769 "3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA), Gallus gallus"
xref: Reactome:REACT_93841 "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al, Drosophila melanogaster"
xref: Reactome:REACT_94333 "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol, Rattus norvegicus"
xref: Reactome:REACT_94596 "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al, Rattus norvegicus"
xref: Reactome:REACT_94731 "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al, Taeniopygia guttata"
xref: Reactome:REACT_94759 "Conversion of 18-hydroxycorticosterone to aldosterone, Mus musculus"
xref: Reactome:REACT_95015 "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol, Mus musculus"
xref: Reactome:REACT_95264 "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al, Sus scrofa"
xref: Reactome:REACT_95305 "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al, Danio rerio"
xref: Reactome:REACT_95310 "Cholesterol is hydroxylated to 25-hydroxycholesterol, Mus musculus"
xref: Reactome:REACT_95732 "3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA), Taeniopygia guttata"
xref: Reactome:REACT_95770 "Testosterone is converted to estradiol, Xenopus tropicalis"
xref: Reactome:REACT_95772 "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al, Danio rerio"
xref: Reactome:REACT_95804 "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al, Bos taurus"
xref: Reactome:REACT_96153 "Testosterone is converted to estradiol, Canis familiaris"
xref: Reactome:REACT_96453 "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al, Rattus norvegicus"
xref: Reactome:REACT_96703 "Hydroxylation of corticosterone to form 18-hydroxycorticosterone, Danio rerio"
xref: Reactome:REACT_96714 "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al, Gallus gallus"
xref: Reactome:REACT_96841 "Androstenedione is converted to estrone by Aromatase (CYP19A1), Taeniopygia guttata"
xref: Reactome:REACT_97534 "3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA), Rattus norvegicus"
xref: Reactome:REACT_97876 "Testosterone is converted to estradiol, Rattus norvegicus"
xref: Reactome:REACT_97885 "5beta-cholestan-3alpha,7alpha,24(S)-triol is hydroxylated to 5beta-cholestan-3alpha,7alpha,24(S), 27-tetrol, Gallus gallus"
xref: Reactome:REACT_98448 "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al, Gallus gallus"
xref: Reactome:REACT_98614 "5beta-cholestan-3alpha,7alpha,24(S)-triol is hydroxylated to 5beta-cholestan-3alpha,7alpha,24(S), 27-tetrol, Sus scrofa"
xref: Reactome:REACT_98717 "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al, Sus scrofa"
xref: Reactome:REACT_98761 "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA), Canis familiaris"
xref: Reactome:REACT_99133 "3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA), Sus scrofa"
xref: Reactome:REACT_9953 "Cholesterol is hydroxylated to 27-hydroxycholesterol by CYP27, Homo sapiens"
xref: Reactome:REACT_9954 "Androstenedione is converted to estrone by Aromatase (CYP19A1), Homo sapiens"
xref: Reactome:REACT_9960 "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al, Homo sapiens"
xref: Reactome:REACT_9963 "Testosterone is converted to estradiol, Homo sapiens"
xref: Reactome:REACT_9976 "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al, Homo sapiens"
xref: Reactome:REACT_9988 "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA), Homo sapiens"
xref: Reactome:REACT_99973 "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al, Danio rerio"
is_a: GO:0004497 ! monooxygenase activity

[Term]
id: GO:0008396
name: oxysterol 7-alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: an oxysterol + NADPH + O2 = 7-alpha-hydroxylated oxysterol + NADP+ + H2O." [PMID:10882791]
synonym: "cytochrome P450 CYP7B1" NARROW []
xref: Reactome:REACT_10066 "24-hydroxycholesterol is 7alpha-hydroxylated to yield cholest-5-ene-3beta,7alpha,24-triol, Homo sapiens"
xref: Reactome:REACT_102623 "25-hydroxycholesterol is 7alpha-hydroxylated by CYP7B1, Sus scrofa"
xref: Reactome:REACT_104165 "24-hydroxycholesterol is 7alpha-hydroxylated to yield cholest-5-ene-3beta,7alpha,24-triol, Bos taurus"
xref: Reactome:REACT_106509 "25-hydroxycholesterol is 7alpha-hydroxylated by CYP7B1, Taeniopygia guttata"
xref: Reactome:REACT_106965 "24-hydroxycholesterol is 7alpha-hydroxylated to yield cholest-5-ene-3beta,7alpha,24-triol, Gallus gallus"
xref: Reactome:REACT_107334 "25-hydroxycholesterol is 7alpha-hydroxylated by CYP7B1, Mus musculus"
xref: Reactome:REACT_109790 "25-hydroxycholesterol is 7alpha-hydroxylated by CYP7B1, Bos taurus"
xref: Reactome:REACT_112158 "24-hydroxycholesterol is 7alpha-hydroxylated to yield cholest-5-ene-3beta,7alpha,24-triol, Dictyostelium discoideum"
xref: Reactome:REACT_112291 "25-hydroxycholesterol is 7alpha-hydroxylated by CYP7B1, Oryza sativa"
xref: Reactome:REACT_112636 "27-hydroxycholesterol is 7alpha-hydroxylated, Arabidopsis thaliana"
xref: Reactome:REACT_112857 "27-hydroxycholesterol is 7alpha-hydroxylated, Dictyostelium discoideum"
xref: Reactome:REACT_113559 "27-hydroxycholesterol is 7alpha-hydroxylated, Oryza sativa"
xref: Reactome:REACT_113710 "27-hydroxycholesterol is 7alpha-hydroxylated, Mycobacterium tuberculosis"
xref: Reactome:REACT_114515 "25-hydroxycholesterol is 7alpha-hydroxylated by CYP7B1, Dictyostelium discoideum"
xref: Reactome:REACT_114585 "24-hydroxycholesterol is 7alpha-hydroxylated to yield cholest-5-ene-3beta,7alpha,24-triol, Arabidopsis thaliana"
xref: Reactome:REACT_114797 "25-hydroxycholesterol is 7alpha-hydroxylated by CYP7B1, Arabidopsis thaliana"
xref: Reactome:REACT_114849 "25-hydroxycholesterol is 7alpha-hydroxylated by CYP7B1, Mycobacterium tuberculosis"
xref: Reactome:REACT_115480 "24-hydroxycholesterol is 7alpha-hydroxylated to yield cholest-5-ene-3beta,7alpha,24-triol, Oryza sativa"
xref: Reactome:REACT_115504 "24-hydroxycholesterol is 7alpha-hydroxylated to yield cholest-5-ene-3beta,7alpha,24-triol, Mycobacterium tuberculosis"
xref: Reactome:REACT_30004 "27-hydroxycholesterol is 7alpha-hydroxylated, Mus musculus"
xref: Reactome:REACT_30911 "27-hydroxycholesterol is 7alpha-hydroxylated, Rattus norvegicus"
xref: Reactome:REACT_30974 "24-hydroxycholesterol is 7alpha-hydroxylated to yield cholest-5-ene-3beta,7alpha,24-triol, Sus scrofa"
xref: Reactome:REACT_31217 "27-hydroxycholesterol is 7alpha-hydroxylated, Taeniopygia guttata"
xref: Reactome:REACT_32313 "24-hydroxycholesterol is 7alpha-hydroxylated to yield cholest-5-ene-3beta,7alpha,24-triol, Mus musculus"
xref: Reactome:REACT_32758 "27-hydroxycholesterol is 7alpha-hydroxylated, Gallus gallus"
xref: Reactome:REACT_33058 "27-hydroxycholesterol is 7alpha-hydroxylated, Sus scrofa"
xref: Reactome:REACT_34312 "27-hydroxycholesterol is 7alpha-hydroxylated, Xenopus tropicalis"
xref: Reactome:REACT_34380 "27-hydroxycholesterol is 7alpha-hydroxylated, Danio rerio"
xref: Reactome:REACT_83366 "24-hydroxycholesterol is 7alpha-hydroxylated to yield cholest-5-ene-3beta,7alpha,24-triol, Danio rerio"
xref: Reactome:REACT_84538 "25-hydroxycholesterol is 7alpha-hydroxylated by CYP7B1, Canis familiaris"
xref: Reactome:REACT_88255 "24-hydroxycholesterol is 7alpha-hydroxylated to yield cholest-5-ene-3beta,7alpha,24-triol, Taeniopygia guttata"
xref: Reactome:REACT_90870 "25-hydroxycholesterol is 7alpha-hydroxylated by CYP7B1, Rattus norvegicus"
xref: Reactome:REACT_91006 "27-hydroxycholesterol is 7alpha-hydroxylated, Canis familiaris"
xref: Reactome:REACT_93049 "24-hydroxycholesterol is 7alpha-hydroxylated to yield cholest-5-ene-3beta,7alpha,24-triol, Canis familiaris"
xref: Reactome:REACT_93832 "24-hydroxycholesterol is 7alpha-hydroxylated to yield cholest-5-ene-3beta,7alpha,24-triol, Rattus norvegicus"
xref: Reactome:REACT_96224 "27-hydroxycholesterol is 7alpha-hydroxylated, Bos taurus"
xref: Reactome:REACT_96813 "25-hydroxycholesterol is 7alpha-hydroxylated by CYP7B1, Gallus gallus"
xref: Reactome:REACT_96977 "25-hydroxycholesterol is 7alpha-hydroxylated by CYP7B1, Danio rerio"
xref: Reactome:REACT_97910 "24-hydroxycholesterol is 7alpha-hydroxylated to yield cholest-5-ene-3beta,7alpha,24-triol, Xenopus tropicalis"
xref: Reactome:REACT_9950 "25-hydroxycholesterol is 7alpha-hydroxylated by CYP7B1, Homo sapiens"
xref: Reactome:REACT_99618 "25-hydroxycholesterol is 7alpha-hydroxylated by CYP7B1, Xenopus tropicalis"
xref: Reactome:REACT_9994 "27-hydroxycholesterol is 7alpha-hydroxylated, Homo sapiens"
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0008397
name: sterol 12-alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: a steroid + donor-H2 + O2 = 12-alpha-hydroxysteroid + H2O." [GOC:mah]
synonym: "cytochrome P450 CYP8B1" NARROW []
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0008398
name: sterol 14-demethylase activity
namespace: molecular_function
def: "Catalysis of the reaction: obtusifoliol + 3 O2 + 3 NADPH + 3 H+ = 4-alpha-methyl-5-alpha-ergosta-8,14,24(28)-trien-3-beta-ol + formate + 3 NADP+ + 3 H2O." [EC:1.14.13.70]
subset: gosubset_prok
synonym: "cytochrome P450 51 activity" NARROW [EC:1.14.13.70]
synonym: "cytochrome P450 CYP51" NARROW []
synonym: "lanosterol 14-alpha-demethylase activity" NARROW [EC:1.14.13.70]
synonym: "lanosterol 14-demethylase activity" NARROW [EC:1.14.13.70]
synonym: "lanosterol 14alpha-demethylase activity" EXACT [EC:1.14.13.70]
synonym: "obtusufoliol 14-demethylase activity" NARROW [EC:1.14.13.70]
synonym: "sterol 14-alpha-demethylase activity" EXACT [EC:1.14.13.70]
synonym: "sterol 14alpha-demethylase activity" EXACT [EC:1.14.13.70]
synonym: "sterol,NADPH:oxygen oxidoreductase (14-methyl cleaving)" EXACT [EC:1.14.13.70]
xref: EC:1.14.13.70
xref: MetaCyc:1.14.13.70-RXN
xref: Reactome:REACT_10006 "Lanosterol is oxidatively demethylated to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol, Homo sapiens"
xref: Reactome:REACT_29216 "Lanosterol is oxidatively demethylated to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol, Sus scrofa"
xref: Reactome:REACT_32427 "Lanosterol is oxidatively demethylated to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol, Danio rerio"
xref: Reactome:REACT_32453 "Lanosterol is oxidatively demethylated to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol, Taeniopygia guttata"
xref: Reactome:REACT_78438 "Lanosterol is oxidatively demethylated to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol, Xenopus tropicalis"
xref: Reactome:REACT_79266 "Lanosterol is oxidatively demethylated to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol, Saccharomyces cerevisiae"
xref: Reactome:REACT_80783 "Lanosterol is oxidatively demethylated to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol, Oryza sativa"
xref: Reactome:REACT_87749 "Lanosterol is oxidatively demethylated to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol, Mycobacterium tuberculosis"
xref: Reactome:REACT_92607 "Lanosterol is oxidatively demethylated to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol, Mus musculus"
xref: Reactome:REACT_93847 "Lanosterol is oxidatively demethylated to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol, Schizosaccharomyces pombe"
xref: Reactome:REACT_93854 "Lanosterol is oxidatively demethylated to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol, Gallus gallus"
xref: Reactome:REACT_95701 "Lanosterol is oxidatively demethylated to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol, Bos taurus"
xref: Reactome:REACT_96210 "Lanosterol is oxidatively demethylated to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol, Canis familiaris"
xref: Reactome:REACT_98680 "Lanosterol is oxidatively demethylated to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol, Dictyostelium discoideum"
xref: Reactome:REACT_99457 "Lanosterol is oxidatively demethylated to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol, Arabidopsis thaliana"
xref: RHEA:14920
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
is_a: GO:0032451 ! demethylase activity

[Term]
id: GO:0008399
name: naphthalene hydroxylase activity
namespace: molecular_function
def: "Catalysis of the conversion of naphthalene to naphthalene 1,2-oxide." [PMID:1742282, PMID:1981702]
synonym: "cytochrome P450 CYP2F2" NARROW []
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0008401
name: retinoic acid 4-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the conversion of retinoic acid to 4-hydroxy-retinoic acid." [PMID:19519282]
synonym: "cytochrome P450 CYP261" NARROW []
xref: Reactome:REACT_100205 "CYP26B1 also deactivates all-trans-retinoic acid by 4-hydroxylation, Canis familiaris"
xref: Reactome:REACT_100356 "CYP26C1 deactivates 9-cis-retinoic acid by 4-hydroxylation, Oryza sativa"
xref: Reactome:REACT_101924 "CYP26B1 also deactivates all-trans-retinoic acid by 4-hydroxylation, Xenopus tropicalis"
xref: Reactome:REACT_102630 "CYP26C1 deactivates 9-cis-retinoic acid by 4-hydroxylation, Rattus norvegicus"
xref: Reactome:REACT_103694 "CYP26B1 also deactivates all-trans-retinoic acid by 4-hydroxylation, Danio rerio"
xref: Reactome:REACT_103985 "CYP26A1 breaks down all-trans-retinoic acid by 4-hydroxylation, Arabidopsis thaliana"
xref: Reactome:REACT_105578 "CYP26A1 breaks down all-trans-retinoic acid by 4-hydroxylation, Rattus norvegicus"
xref: Reactome:REACT_105799 "CYP26A1 breaks down all-trans-retinoic acid by 4-hydroxylation, Mus musculus"
xref: Reactome:REACT_105966 "CYP26A1 breaks down all-trans-retinoic acid by 4-hydroxylation, Oryza sativa"
xref: Reactome:REACT_108210 "CYP26B1 also deactivates all-trans-retinoic acid by 4-hydroxylation, Rattus norvegicus"
xref: Reactome:REACT_108488 "CYP26C1 deactivates 9-cis-retinoic acid by 4-hydroxylation, Canis familiaris"
xref: Reactome:REACT_13550 "CYP26B1 also deactivates all-trans-retinoic acid by 4-hydroxylation, Homo sapiens"
xref: Reactome:REACT_13572 "CYP26A1 breaks down all-trans-retinoic acid by 4-hydroxylation, Homo sapiens"
xref: Reactome:REACT_13626 "CYP2S1 can deactivate all-trans-retinoic acid, Homo sapiens"
xref: Reactome:REACT_13793 "CYP26C1 deactivates 9-cis-retinoic acid by 4-hydroxylation, Homo sapiens"
xref: Reactome:REACT_29027 "CYP2S1 can deactivate all-trans-retinoic acid, Bos taurus"
xref: Reactome:REACT_29904 "CYP26B1 also deactivates all-trans-retinoic acid by 4-hydroxylation, Taeniopygia guttata"
xref: Reactome:REACT_30211 "CYP26B1 also deactivates all-trans-retinoic acid by 4-hydroxylation, Mus musculus"
xref: Reactome:REACT_31578 "CYP26A1 breaks down all-trans-retinoic acid by 4-hydroxylation, Xenopus tropicalis"
xref: Reactome:REACT_31793 "CYP26A1 breaks down all-trans-retinoic acid by 4-hydroxylation, Gallus gallus"
xref: Reactome:REACT_32097 "CYP26A1 breaks down all-trans-retinoic acid by 4-hydroxylation, Taeniopygia guttata"
xref: Reactome:REACT_33825 "CYP2S1 can deactivate all-trans-retinoic acid, Xenopus tropicalis"
xref: Reactome:REACT_77205 "CYP2S1 can deactivate all-trans-retinoic acid, Danio rerio"
xref: Reactome:REACT_80670 "CYP26B1 also deactivates all-trans-retinoic acid by 4-hydroxylation, Gallus gallus"
xref: Reactome:REACT_80671 "CYP26B1 also deactivates all-trans-retinoic acid by 4-hydroxylation, Bos taurus"
xref: Reactome:REACT_81653 "CYP26C1 deactivates 9-cis-retinoic acid by 4-hydroxylation, Danio rerio"
xref: Reactome:REACT_83210 "CYP26A1 breaks down all-trans-retinoic acid by 4-hydroxylation, Sus scrofa"
xref: Reactome:REACT_84340 "CYP26C1 deactivates 9-cis-retinoic acid by 4-hydroxylation, Bos taurus"
xref: Reactome:REACT_84750 "CYP26C1 deactivates 9-cis-retinoic acid by 4-hydroxylation, Sus scrofa"
xref: Reactome:REACT_84915 "CYP2S1 can deactivate all-trans-retinoic acid, Mus musculus"
xref: Reactome:REACT_86481 "CYP2S1 can deactivate all-trans-retinoic acid, Rattus norvegicus"
xref: Reactome:REACT_86548 "CYP26C1 deactivates 9-cis-retinoic acid by 4-hydroxylation, Taeniopygia guttata"
xref: Reactome:REACT_86708 "CYP26C1 deactivates 9-cis-retinoic acid by 4-hydroxylation, Mus musculus"
xref: Reactome:REACT_90431 "CYP26C1 deactivates 9-cis-retinoic acid by 4-hydroxylation, Gallus gallus"
xref: Reactome:REACT_90993 "CYP26A1 breaks down all-trans-retinoic acid by 4-hydroxylation, Danio rerio"
xref: Reactome:REACT_92470 "CYP26A1 breaks down all-trans-retinoic acid by 4-hydroxylation, Bos taurus"
xref: Reactome:REACT_93056 "CYP2S1 can deactivate all-trans-retinoic acid, Canis familiaris"
xref: Reactome:REACT_93531 "CYP26B1 also deactivates all-trans-retinoic acid by 4-hydroxylation, Oryza sativa"
xref: Reactome:REACT_93640 "CYP26C1 deactivates 9-cis-retinoic acid by 4-hydroxylation, Arabidopsis thaliana"
xref: Reactome:REACT_93723 "CYP26C1 deactivates 9-cis-retinoic acid by 4-hydroxylation, Xenopus tropicalis"
xref: Reactome:REACT_95096 "CYP26B1 also deactivates all-trans-retinoic acid by 4-hydroxylation, Sus scrofa"
xref: Reactome:REACT_97210 "CYP26B1 also deactivates all-trans-retinoic acid by 4-hydroxylation, Arabidopsis thaliana"
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0008403
name: 25-hydroxycholecalciferol-24-hydroxylase activity
namespace: molecular_function
alt_id: GO:0030344
def: "Catalysis of the hydroxylation of C-24 of 25-hydroxycholecalciferol (25-hydroxyvitamin D3) to form 24(R),25-dihydroxycholecalciferol." [ISBN:0471331309]
synonym: "25-hydroxyvitamin D3 24-hydroxylase activity" EXACT []
synonym: "cytochrome P450 CYP24" NARROW []
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
is_a: GO:0070576 ! vitamin D 24-hydroxylase activity

[Term]
id: GO:0008404
name: arachidonic acid 14,15-epoxygenase activity
namespace: molecular_function
def: "Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-14,15-epoxyeicosatrienoic acid." [http://lipidlibrary.aocs.org/Lipids/eic_hete/index.htm, PMID:10681399]
synonym: "cytochrome P450 CYP2C29" NARROW []
synonym: "cytochrome P450 CYP2C39" NARROW []
is_a: GO:0008392 ! arachidonic acid epoxygenase activity

[Term]
id: GO:0008405
name: arachidonic acid 11,12-epoxygenase activity
namespace: molecular_function
def: "Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-11,12-epoxyeicosatrienoic acid." [http://lipidlibrary.aocs.org/Lipids/eic_hete/index.htm, PMID:10681399]
synonym: "cytochrome P450 CYP2C38" NARROW []
is_a: GO:0008392 ! arachidonic acid epoxygenase activity

[Term]
id: GO:0008406
name: gonad development
namespace: biological_process
def: "The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones." [GOC:ems, ISBN:0198506732]
synonym: "gonadogenesis" EXACT [GOC:cjm]
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048513 ! animal organ development
is_a: GO:0048608 ! reproductive structure development
relationship: part_of GO:0045137 ! development of primary sexual characteristics

[Term]
id: GO:0008407
name: chaeta morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:go_curators]
synonym: "bristle morphogenesis" NARROW [GOC:bf, GOC:dos]
is_a: GO:0009887 ! organ morphogenesis
relationship: part_of GO:0022416 ! chaeta development

[Term]
id: GO:0008408
name: 3'-5' exonuclease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]
subset: gosubset_prok
synonym: "3'-5'-exonuclease activity" EXACT []
is_a: GO:0004527 ! exonuclease activity

[Term]
id: GO:0008409
name: 5'-3' exonuclease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end." [GOC:ai]
subset: gosubset_prok
is_a: GO:0004527 ! exonuclease activity

[Term]
id: GO:0008410
name: CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor)." [GOC:jl]
subset: gosubset_prok
xref: EC:2.8.3.-
is_a: GO:0016782 ! transferase activity, transferring sulfur-containing groups

[Term]
id: GO:0008411
name: 4-hydroxybutyrate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a coenzyme A (CoA) group to 4-hydroxybutyrate." [GOC:jl]
subset: gosubset_prok
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0008412
name: 4-hydroxybenzoate octaprenyltransferase activity
namespace: molecular_function
alt_id: GO:0000043
alt_id: GO:0048043
alt_id: GO:0048044
def: "Catalysis of the reaction: farnesylfarnesylgeranyl diphosphate + p-hydroxybenzoate = 3-octaprenyl-4-hydroxybenzoate + diphosphate." [MetaCyc:4OHBENZOATE-OCTAPRENYLTRANSFER-RXN]
subset: gosubset_prok
synonym: "4-HB polyprenyltransferase activity" EXACT []
synonym: "para-hydroxybenzoate transferase activity" EXACT []
synonym: "para-hydroxybenzoate-polyprenyl diphosphate transferase activity" EXACT []
synonym: "para-hydroxybenzoate:polyprenyltransferase activity" EXACT []
synonym: "PHB polyprenyl diphosphate transferase activity" EXACT []
xref: EC:2.5.1.-
xref: MetaCyc:4OHBENZOATE-OCTAPRENYLTRANSFER-RXN
is_a: GO:0002094 ! polyprenyltransferase activity

[Term]
id: GO:0008413
name: 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 8-oxo-7,8-dihydroguanosine triphosphate = 8-oxo-7,8-dihydroguanosine phosphate + diphosphate. 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for transcription." [PMID:15878881]
subset: gosubset_prok
synonym: "7,8-dihydro-8-oxoguanine-triphosphatase activity" EXACT []
synonym: "8-oxo-7,8-dihydroguanine triphosphatase activity" EXACT []
synonym: "8-oxo-7,8-dihydroguanosine triphosphatase activity" EXACT []
synonym: "8-oxo-GTPase activity" EXACT []
xref: EC:3.6.1.-
is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity

[Term]
id: GO:0008414
name: CDP-alcohol phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a CDP-alcohol group from one compound to another." [GOC:jl]
is_a: GO:0016740 ! transferase activity

[Term]
id: GO:0008416
name: delta5-delta2,4-dienoyl-CoA isomerase activity
namespace: molecular_function
def: "Catalysis of the isomerization of 3,5-dienoyl-CoA to 2,4-dienoyl-CoA." [PMID:11278886]
xref: EC:5.3.3.-
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0008417
name: fucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai]
subset: gosubset_prok
xref: EC:2.4.1.-
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups
relationship: part_of GO:0036065 ! fucosylation

[Term]
id: GO:0008418
name: protein-N-terminal asparagine amidohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein-L-asparagine + H2O = protein-L-aspartate + NH3. This reaction is the deamidation of an N-terminal asparagine residue in a peptide or protein." [PMID:8910481]
xref: EC:3.5.1.-
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0008419
name: RNA lariat debranching enzyme activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of branched RNA structures that contain vicinal 2'-5'- and 3'-5'-phosphodiester bonds at a branch point nucleotide." [PMID:7519612]
is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0008420
name: CTD phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: phospho-(DNA-directed RNA polymerase) + H2O = (DNA-directed RNA polymerase) + phosphate." [EC:3.1.3.16]
is_a: GO:0004722 ! protein serine/threonine phosphatase activity

[Term]
id: GO:0008421
name: long-chain fatty-acyl-glutamate deacylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-long-chain-fatty-acyl-L-glutamate + H2O = a fatty acid anion + L-glutamate." [EC:3.5.1.55]
synonym: "long-chain acylglutamate amidase activity" EXACT [EC:3.5.1.55]
synonym: "long-chain aminoacylase activity" EXACT [EC:3.5.1.55]
synonym: "long-chain fatty acyl-glutamate deacylase activity" EXACT [GOC:mah]
synonym: "long-chain-fatty-acyl-glutamate deacylase activity" EXACT []
synonym: "N-long-chain-fatty-acyl-L-glutamate amidohydrolase activity" EXACT [EC:3.5.1.55]
xref: EC:3.5.1.55
xref: MetaCyc:3.5.1.55-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0008422
name: beta-glucosidase activity
namespace: molecular_function
alt_id: GO:0016983
def: "Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose." [EC:3.2.1.21]
subset: gosubset_prok
synonym: "amygdalase activity" NARROW [EC:3.2.1.21]
synonym: "amygdalinase" BROAD [EC:3.2.1.21]
synonym: "arbutinase activity" EXACT [EC:3.2.1.21]
synonym: "aryl-beta-glucosidase activity" EXACT [EC:3.2.1.21]
synonym: "beta-1,6-glucosidase activity" EXACT [EC:3.2.1.21]
synonym: "beta-D-glucosidase activity" EXACT [EC:3.2.1.21]
synonym: "beta-D-glucoside glucohydrolase activity" EXACT [EC:3.2.1.21]
synonym: "beta-glucoside glucohydrolase activity" EXACT [EC:3.2.1.21]
synonym: "cellobiase activity" NARROW [EC:3.2.1.21]
synonym: "cytokine beta-glucosidase activity" NARROW []
synonym: "elaterase activity" NARROW [EC:3.2.1.21]
synonym: "emulsin" RELATED [EC:3.2.1.21]
synonym: "gentiobiase activity" NARROW [EC:3.2.1.21]
synonym: "gentobiase activity" NARROW [EC:3.2.1.21]
synonym: "limarase activity" NARROW [EC:3.2.1.21]
synonym: "p-nitrophenyl beta-glucosidase activity" EXACT [EC:3.2.1.21]
synonym: "primeverosidase activity" NARROW [EC:3.2.1.21]
synonym: "salicilinase activity" NARROW [EC:3.2.1.21]
xref: EC:3.2.1.21
xref: MetaCyc:3.2.1.21-RXN
is_a: GO:0015926 ! glucosidase activity

[Term]
id: GO:0008423
name: obsolete bleomycin hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the inactivation of bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a peptide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred." [EC:3.4.22.40]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "aminopeptidase C (Lactococcus lactis)" NARROW [EC:3.4.22.40]
synonym: "bleomycin hydrolase activity" EXACT []
xref: EC:3.4.22.40
xref: MetaCyc:3.4.22.40-RXN
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0008424
name: glycoprotein 6-alpha-L-fucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP-L-fucose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-[alpha-L-fucosyl-(1->6)]-N-acetyl-beta-D-glucosaminyl}asparagine + GDP + H(+)." [EC:2.4.1.68, RHEA:12988]
synonym: "FucT" RELATED [EC:2.4.1.68]
synonym: "GDP-fucose--glycoprotein fucosyltransferase activity" EXACT [EC:2.4.1.68]
synonym: "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha(1,6)fucosyltransferase activity" EXACT [EC:2.4.1.68]
synonym: "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha(1->6)fucosyltransferase activity" EXACT [EC:2.4.1.68]
synonym: "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha-(1,6)fucosyltransferase activity" EXACT [EC:2.4.1.68]
synonym: "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha-(1->6)fucosyltransferase activity" EXACT [EC:2.4.1.68]
synonym: "GDP-L-fucose--glycoprotein fucosyltransferase activity" EXACT [EC:2.4.1.68]
synonym: "GDPfucose-glycoprotein fucosyltransferase activity" EXACT [EC:2.4.1.68]
synonym: "glycoprotein fucosyltransferase activity" BROAD [EC:2.4.1.68]
synonym: "guanosine diphosphofucose--glycoprotein fucosyltransferase activity" EXACT [EC:2.4.1.68]
xref: EC:2.4.1.68
xref: KEGG:R05988
xref: MetaCyc:2.4.1.68-RXN
xref: Reactome:REACT_25399 "Addition of alpha 1,6 fucose to the first GlcNAc of the N-glycan, Homo sapiens"
xref: RHEA:12988
is_a: GO:0046921 ! alpha-(1->6)-fucosyltransferase activity
relationship: part_of GO:0036071 ! N-glycan fucosylation

[Term]
id: GO:0008425
name: 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-polyprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:kd, PMID:9083048]
subset: gosubset_prok
synonym: "2-polyprenyl-6-methoxy-1,4-benzoquinone methylase activity" EXACT []
synonym: "coenzyme Q biosynthesis methyltransferase activity" EXACT []
synonym: "coenzyme Q biosynthetic process methyltransferase activity" EXACT []
synonym: "ubiquinone biosynthesis methyltransferase activity" BROAD []
synonym: "ubiquinone biosynthetic process methyltransferase activity" BROAD []
xref: EC:2.1.1.-
is_a: GO:0030580 ! quinone cofactor methyltransferase activity

[Term]
id: GO:0008426
name: protein kinase C inhibitor activity
namespace: molecular_function
alt_id: GO:0004863
def: "Stops, prevents or reduces the activity of protein kinase C, an enzyme which phosphorylates a protein." [GOC:ai]
synonym: "diacylglycerol-activated phospholipid-dependent PKC inhibitor activity" EXACT []
synonym: "diacylglycerol-activated phospholipid-dependent protein kinase C inhibitor activity" EXACT []
synonym: "PKC inhibitor activity" EXACT []
is_a: GO:0030291 ! protein serine/threonine kinase inhibitor activity
relationship: has_part GO:0005080 ! protein kinase C binding
relationship: negatively_regulates GO:0004697 ! protein kinase C activity

[Term]
id: GO:0008427
name: calcium-dependent protein kinase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a calcium-dependent protein kinase." [GOC:mah]
is_a: GO:0004860 ! protein kinase inhibitor activity
is_a: GO:0010858 ! calcium-dependent protein kinase regulator activity

[Term]
id: GO:0008428
name: ribonuclease inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a ribonuclease, any enzyme that catalyzes the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:ai]
subset: gosubset_prok
is_a: GO:0004857 ! enzyme inhibitor activity
relationship: negatively_regulates GO:0004540 ! ribonuclease activity

[Term]
id: GO:0008429
name: phosphatidylethanolamine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine." [ISBN:0198506732]
is_a: GO:0005543 ! phospholipid binding

[Term]
id: GO:0008430
name: selenium binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with selenium (Se)." [GOC:ai]
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0008431
name: vitamin E binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant." [CHEBI:33234, GOC:curators, ISBN:0721662544]
subset: gosubset_prok
synonym: "alpha-tocopherol binding" NARROW []
synonym: "tocopherol binding" EXACT []
is_a: GO:0019842 ! vitamin binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding

[Term]
id: GO:0008432
name: JUN kinase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with JUN kinase, an enzyme that catalyzes the phosphorylation and activation of members of the JUN family." [GOC:jl]
synonym: "JNK binding" EXACT [GOC:BHF, GOC:ebc]
is_a: GO:0019901 ! protein kinase binding

[Term]
id: GO:0008434
name: calcitriol receptor activity
namespace: molecular_function
def: "Combining with calcitriol, the hormonally active form of vitamin D3, and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II." [CHEBI:17823, GOC:bf, GOC:signaling, PMID:16549446, PMID:17082781, Wikipedia:Calcitriol_receptor]
comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'.
synonym: "1,25-(OH)2D3 receptor activity" EXACT [Wikipedia:Calcitriol]
synonym: "1,25-dihydroxycholecalciferol receptor activity" EXACT [Wikipedia:Calcitriol]
synonym: "1,25-dihydroxyvitamin D3 receptor activity" EXACT [Wikipedia:Calcitriol]
synonym: "1alpha,25(OH)2D3 receptor activity" EXACT [PMID:16549446]
synonym: "1alpha,25-dihydroxyvitamin D3 receptor activity" EXACT [CHEBI:17823]
synonym: "vitamin D3 receptor activity" RELATED [GOC:bf, Wikipedia:Calcitriol_receptor]
is_a: GO:0004879 ! RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
is_a: GO:0038023 ! signaling receptor activity
relationship: has_part GO:1902098 ! calcitriol binding
relationship: part_of GO:0070561 ! vitamin D receptor signaling pathway

[Term]
id: GO:0008435
name: obsolete anticoagulant activity
namespace: molecular_function
def: "OBSOLETE. Functions to retard or prevent coagulation. Often used in the context of blood or milk coagulation." [ISBN:0198506732]
comment: This term was made obsolete because it represents a biological process.
synonym: "anticoagulant activity" EXACT []
is_obsolete: true
replaced_by: GO:0050819

[Term]
id: GO:0008436
name: obsolete heterogeneous nuclear ribonucleoprotein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it describes a cellular component rather than a molecular function.
synonym: "heterogeneous nuclear ribonucleoprotein" EXACT []
synonym: "hnRNP" EXACT []
is_obsolete: true
replaced_by: GO:0030530

[Term]
id: GO:0008437
name: thyrotropin-releasing hormone activity
namespace: molecular_function
def: "The action characteristic of thyrotropin-releasing hormone (TRH), a hormone released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary." [ISBN:0198506732]
synonym: "thyrotropin releasing hormone activity" EXACT []
synonym: "TRH activity" EXACT [ISBN:0198506732]
is_a: GO:0005179 ! hormone activity

[Term]
id: GO:0008438
name: obsolete 1-phosphatidylinositol-5-phosphate kinase
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: diphosphate + a purine nucleoside = phosphate + a purine mononucleotide." [EC:2.7.1.143]
comment: This term was made obsolete because it is a redundant grouping term with only one child. It is also incorrectly defined and had an incorrect EC dbxref.
synonym: "1-phosphatidylinositol-5-phosphate kinase" EXACT []
is_obsolete: true
consider: GO:0016309

[Term]
id: GO:0008439
name: obsolete monophenol monooxygenase activator activity
namespace: molecular_function
def: "OBSOLETE. Increases the activity of the enzyme monophenol monooxygenase." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "monophenol monooxygenase activator activity" EXACT []
synonym: "prophenol oxidase activator" RELATED []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0008440
name: inositol-1,4,5-trisphosphate 3-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H(+)." [EC:2.7.1.127, RHEA:11023]
synonym: "1D-myo-inositol-trisphosphate 3-kinase activity" EXACT []
synonym: "ATP:1D-myo-inositol-1,4,5-trisphosphate 3-phosphotransferase activity" EXACT [EC:2.7.1.127]
synonym: "inositol trisphosphate 3-kinase activity" EXACT []
synonym: "inositol-trisphosphate 3-kinase activity" EXACT []
synonym: "ins(1,4,5)P(3) 3-kinase activity" EXACT [EC:2.7.1.127]
synonym: "Ins(1,4,5)P3 3-kinase activity" EXACT [EC:2.7.1.127]
synonym: "IP3 3-kinase activity" NARROW [EC:2.7.1.127]
synonym: "IP3K activity" NARROW [EC:2.7.1.127]
xref: EC:2.7.1.127
xref: KEGG:R03433
xref: MetaCyc:2.7.1.127-RXN
xref: RHEA:11023
is_a: GO:0051766 ! inositol trisphosphate kinase activity

[Term]
id: GO:0008441
name: 3'(2'),5'-bisphosphate nucleotidase activity
namespace: molecular_function
def: "Catalysis of the reaction: adenosine 3',5'-bisphosphate + H2O = adenosine 5'-phosphate + phosphate." [EC:3.1.3.7]
subset: gosubset_prok
synonym: "3'(2'),5' bisphosphate nucleotidase activity" EXACT []
synonym: "3'(2'),5'-bisphosphonucleoside 3'(2')-phosphohydrolase activity" EXACT [EC:3.1.3.7]
synonym: "3'-phosphoadenylylsulfate 3'-phosphatase activity" EXACT [EC:3.1.3.7]
synonym: "adenosine-3'(2'),5'-bisphosphate 3'(2')-phosphohydrolase activity" EXACT [EC:3.1.3.7]
synonym: "DPNPase activity" EXACT [EC:3.1.3.7]
synonym: "phosphoadenylate 3'-nucleotidase activity" EXACT [EC:3.1.3.7]
xref: EC:3.1.3.7
xref: MetaCyc:325-BISPHOSPHATE-NUCLEOTIDASE-RXN
xref: Reactome:REACT_101365 "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate, Caenorhabditis elegans"
xref: Reactome:REACT_104279 "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate, Canis familiaris"
xref: Reactome:REACT_105414 "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate, Gallus gallus"
xref: Reactome:REACT_107127 "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_108586 "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate, Rattus norvegicus"
xref: Reactome:REACT_27229 "PAPS is dephosphorylated to APS, Mycobacterium tuberculosis"
xref: Reactome:REACT_28278 "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate, Xenopus tropicalis"
xref: Reactome:REACT_33593 "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate, Drosophila melanogaster"
xref: Reactome:REACT_6763 "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate, Homo sapiens"
xref: Reactome:REACT_78675 "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate, Mus musculus"
xref: Reactome:REACT_83375 "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate, Bos taurus"
xref: Reactome:REACT_84547 "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate, Sus scrofa"
xref: Reactome:REACT_94834 "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate, Taeniopygia guttata"
xref: Reactome:REACT_95761 "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate, Danio rerio"
xref: RHEA:10043
is_a: GO:0008252 ! nucleotidase activity

[Term]
id: GO:0008442
name: 3-hydroxyisobutyrate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+." [EC:1.1.1.31]
subset: gosubset_prok
xref: EC:1.1.1.31
xref: MetaCyc:3-HYDROXYISOBUTYRATE-DEHYDROGENASE-RXN
xref: Reactome:REACT_102315 "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+, Sus scrofa"
xref: Reactome:REACT_105260 "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+, Oryza sativa"
xref: Reactome:REACT_106538 "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+, Mycobacterium tuberculosis"
xref: Reactome:REACT_110404 "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+, Taeniopygia guttata"
xref: Reactome:REACT_1514 "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+, Homo sapiens"
xref: Reactome:REACT_21400 "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+, Homo sapiens"
xref: Reactome:REACT_30559 "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+, Rattus norvegicus"
xref: Reactome:REACT_31961 "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+, Canis familiaris"
xref: Reactome:REACT_77251 "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+, Dictyostelium discoideum"
xref: Reactome:REACT_80907 "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+, Gallus gallus"
xref: Reactome:REACT_84674 "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+, Danio rerio"
xref: Reactome:REACT_87460 "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+, Arabidopsis thaliana"
xref: Reactome:REACT_91589 "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+, Mus musculus"
xref: Reactome:REACT_93614 "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+, Xenopus tropicalis"
xref: Reactome:REACT_95495 "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+, Caenorhabditis elegans"
xref: Reactome:REACT_97173 "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+, Bos taurus"
xref: RHEA:17684
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008443
name: phosphofructokinase activity
namespace: molecular_function
def: "Catalysis of the transfer of a phosphate group, usually from ATP, to a fructose substrate molecule." [GOC:jl]
subset: gosubset_prok
xref: EC:2.7.1.-
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0008444
name: CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: sn-glycerol 3-phosphate + CDP-diacylglycerol = 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate + CMP + H(+)." [EC:2.7.8.5, RHEA:12596]
subset: gosubset_prok
synonym: "3-phosphatidyl-1'-glycerol-3'-phosphate synthase activity" EXACT [EC:2.7.8.5]
synonym: "CDP-diacylglycerol:sn-glycerol-3-phosphate 3-phosphatidyltransferase activity" EXACT [EC:2.7.8.5]
synonym: "CDPdiacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity" EXACT [EC:2.7.8.5]
synonym: "CDPdiacylglycerol-sn-glycerol-3-phosphate 3-phosphatidyltransferase activity" EXACT [EC:2.7.8.5]
synonym: "CDPdiacylglycerol:glycerol-3-phosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5]
synonym: "CDPdiacylglycerol:sn-glycero-3-phosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5]
synonym: "cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):sn-glycerol-3-phosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5]
synonym: "glycerol 3-phosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5]
synonym: "glycerol phosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5]
synonym: "glycerophosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5]
synonym: "PGP synthase activity" EXACT [EC:2.7.8.5]
synonym: "phosphatidylglycerol phosphate synthase activity" EXACT [EC:2.7.8.5]
synonym: "phosphatidylglycerol phosphate synthetase activity" EXACT [EC:2.7.8.5]
synonym: "phosphatidylglycerolphosphate synthase activity" EXACT [EC:2.7.8.5]
synonym: "phosphatidylglycerophosphate synthase activity" EXACT [EC:2.7.8.5]
synonym: "phosphatidylglycerophosphate synthetase activity" EXACT [EC:2.7.8.5]
synonym: "sn-glycerol-3-phosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5]
xref: EC:2.7.8.5
xref: KEGG:R01801
xref: MetaCyc:PHOSPHAGLYPSYN-RXN
xref: RHEA:12596
is_a: GO:0017169 ! CDP-alcohol phosphatidyltransferase activity

[Term]
id: GO:0008445
name: D-aspartate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-aspartate + H2O + O2 = oxaloacetate + NH3 + hydrogen peroxide." [EC:1.4.3.1]
synonym: "aspartic oxidase activity" EXACT [EC:1.4.3.1]
synonym: "D-aspartate:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.1]
synonym: "D-aspartic oxidase activity" EXACT [EC:1.4.3.1]
xref: EC:1.4.3.1
xref: MetaCyc:D-ASPARTATE-OXIDASE-RXN
xref: RHEA:12515
is_a: GO:0003884 ! D-amino-acid oxidase activity
is_a: GO:0015922 ! aspartate oxidase activity

[Term]
id: GO:0008446
name: GDP-mannose 4,6-dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-alpha-D-mannose = GDP-4-dehydro-6-deoxy-alpha-D-mannose + H(2)O." [EC:4.2.1.47, RHEA:23823]
subset: gosubset_prok
synonym: "GDP-D-mannose 4,6-dehydratase activity" EXACT [EC:4.2.1.47]
synonym: "GDP-D-mannose dehydratase activity" EXACT [EC:4.2.1.47]
synonym: "GDP-mannose 4,6-hydro-lyase (GDP-4-dehydro-6-deoxy-D-mannose-forming)" EXACT [EC:4.2.1.47]
synonym: "GDP-mannose 4,6-hydro-lyase activity" EXACT [EC:4.2.1.47]
synonym: "GDPmannose 4,6-dehydratase activity" EXACT [EC:4.2.1.47]
synonym: "Gmd" RELATED [EC:4.2.1.47]
synonym: "guanosine 5'-diphosphate-D-mannose oxidoreductase activity" EXACT [EC:4.2.1.47]
synonym: "guanosine diphosphomannose 4,6-dehydratase activity" EXACT [EC:4.2.1.47]
synonym: "guanosine diphosphomannose oxidoreductase activity" EXACT [EC:4.2.1.47]
xref: EC:4.2.1.47
xref: KEGG:R00888
xref: MetaCyc:GDPMANDEHYDRA-RXN
xref: RHEA:23823
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0008447
name: L-ascorbate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 L-ascorbate + O2 = 2 dehydroascorbate + 2 H2O." [EC:1.10.3.3]
synonym: "AA oxidase activity" EXACT [EC:1.10.3.3]
synonym: "AAO" RELATED [EC:1.10.3.3]
synonym: "ascorbase activity" EXACT [EC:1.10.3.3]
synonym: "ascorbate dehydrogenase activity" EXACT [EC:1.10.3.3]
synonym: "ascorbate oxidase activity" EXACT [EC:1.10.3.3]
synonym: "ascorbic acid oxidase activity" EXACT [EC:1.10.3.3]
synonym: "ascorbic oxidase activity" EXACT [EC:1.10.3.3]
synonym: "L-ascorbate:O2 oxidoreductase activity" EXACT [EC:1.10.3.3]
synonym: "L-ascorbate:oxygen oxidoreductase activity" EXACT [EC:1.10.3.3]
synonym: "L-ascorbic acid oxidase activity" EXACT [EC:1.10.3.3]
xref: EC:1.10.3.3
xref: MetaCyc:L-ASCORBATE-OXIDASE-RXN
xref: RHEA:30246
is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor

[Term]
id: GO:0008448
name: N-acetylglucosamine-6-phosphate deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate." [EC:3.5.1.25]
subset: gosubset_prok
synonym: "2-acetamido-2-deoxy-D-glucose-6-phosphate amidohydrolase activity" EXACT [EC:3.5.1.25]
synonym: "acetylaminodeoxyglucosephosphate acetylhydrolase activity" EXACT [EC:3.5.1.25]
synonym: "acetylglucosamine phosphate deacetylase activity" EXACT [EC:3.5.1.25]
synonym: "N-acetyl-D-glucosamine-6-phosphate amidohydrolase activity" EXACT [EC:3.5.1.25]
xref: EC:3.5.1.25
xref: MetaCyc:NAG6PDEACET-RXN
xref: RHEA:22939
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0019213 ! deacetylase activity

[Term]
id: GO:0008449
name: N-acetylglucosamine-6-sulfatase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the 6-sulfate group of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate." [EC:3.1.6.14]
subset: gosubset_prok
synonym: "2-acetamido-2-deoxy-D-glucose 6-sulfate sulfatase activity" EXACT [EC:3.1.6.14]
synonym: "acetylglucosamine 6-sulfatase activity" EXACT [EC:3.1.6.14]
synonym: "chondroitinsulfatase" BROAD [EC:3.1.6.14]
synonym: "glucosamine-6-sulfatase activity" EXACT [EC:3.1.6.14]
synonym: "N-acetyl-D-glucosamine-6-sulfate 6-sulfohydrolase activity" EXACT [EC:3.1.6.14]
synonym: "N-acetylglucosamine 6-sulfate sulfatase activity" EXACT [EC:3.1.6.14]
synonym: "N-acetylglucosamine-6-sulphatase activity" EXACT []
synonym: "O,N-disulfate O-sulfohydrolase activity" EXACT [EC:3.1.6.14]
xref: EC:3.1.6.14
xref: MetaCyc:3.1.6.14-RXN
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0008450
name: obsolete O-sialoglycoprotein endopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of O-sialoglycoproteins; cleaves the -Arg31-Asp32- bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated." [EC:3.4.24.57]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "glycophorin A proteinase activity" EXACT [EC:3.4.24.57]
synonym: "glycoprotease activity" RELATED [EC:3.4.24.57]
synonym: "glycoproteinase activity" EXACT [EC:3.4.24.57]
synonym: "O-sialoglycoprotein endopeptidase activity" EXACT []
synonym: "sialoglycoprotease activity" EXACT [EC:3.4.24.57]
synonym: "sialoglycoproteinase activity" EXACT [EC:3.4.24.57]
xref: EC:3.4.24.57
xref: MetaCyc:3.4.24.57-RXN
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0008451
name: obsolete X-Pro aminopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of any N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide." [EC:3.4.11.9]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "aminoacylproline aminopeptidase activity" EXACT [EC:3.4.11.9]
synonym: "aminopeptidase P" EXACT []
synonym: "proline aminopeptidase" BROAD [EC:3.4.11.9]
synonym: "X-Pro aminopeptidase activity" EXACT []
synonym: "Xaa-Pro aminopeptidase activity" EXACT []
xref: EC:3.4.11.9
xref: MetaCyc:3.4.11.9-RXN
is_obsolete: true
replaced_by: GO:0004177

[Term]
id: GO:0008452
name: RNA ligase activity
namespace: molecular_function
def: "Catalysis of the formation of a phosphodiester bond between a hydroxyl group at the end of one RNA chain and the 5'-phosphate group at the end of another." [GOC:mah]
subset: gosubset_prok
xref: EC:6.5.1.-
is_a: GO:0016886 ! ligase activity, forming phosphoric ester bonds

[Term]
id: GO:0008453
name: alanine-glyoxylate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-alanine + glyoxylate = pyruvate + glycine." [EC:2.6.1.44]
subset: gosubset_prok
synonym: "AGT activity" EXACT [EC:2.6.1.44]
synonym: "alanine--glyoxylate aminotransferase activity" EXACT [EC:2.6.1.44]
synonym: "alanine-glyoxylate aminotransferase activity" EXACT []
synonym: "alanine-glyoxylic aminotransferase activity" EXACT [EC:2.6.1.44]
synonym: "L-alanine-glycine transaminase activity" EXACT [EC:2.6.1.44]
synonym: "L-alanine:glyoxylate aminotransferase activity" EXACT [EC:2.6.1.44]
xref: EC:2.6.1.44
xref: MetaCyc:ALANINE--GLYOXYLATE-AMINOTRANSFERASE-RXN
xref: Reactome:REACT_100442 "glyoxylate + alanine => glycine + pyruvate [peroxisome], Danio rerio"
xref: Reactome:REACT_106031 "glyoxylate + alanine => glycine + pyruvate [peroxisome], Xenopus tropicalis"
xref: Reactome:REACT_109387 "glyoxylate + alanine => glycine + pyruvate [peroxisome], Caenorhabditis elegans"
xref: Reactome:REACT_16972 "glyoxylate + alanine => glycine + pyruvate [peroxisome], Homo sapiens"
xref: Reactome:REACT_25087 "glyoxylate + alanine => glycine + pyruvate [mitochondrial matrix], Homo sapiens"
xref: Reactome:REACT_80428 "glyoxylate + alanine => glycine + pyruvate [peroxisome], Rattus norvegicus"
xref: Reactome:REACT_87027 "glyoxylate + alanine => glycine + pyruvate [peroxisome], Mus musculus"
xref: Reactome:REACT_87296 "glyoxylate + alanine => glycine + pyruvate [peroxisome], Saccharomyces cerevisiae"
xref: Reactome:REACT_87387 "glyoxylate + alanine => glycine + pyruvate [peroxisome], Dictyostelium discoideum"
xref: Reactome:REACT_87423 "glyoxylate + alanine => glycine + pyruvate [peroxisome], Staphylococcus aureus N315"
xref: Reactome:REACT_89772 "glyoxylate + alanine => glycine + pyruvate [peroxisome], Canis familiaris"
xref: Reactome:REACT_89791 "glyoxylate + alanine => glycine + pyruvate [peroxisome], Drosophila melanogaster"
xref: Reactome:REACT_90629 "glyoxylate + alanine => glycine + pyruvate [peroxisome], Bos taurus"
xref: Reactome:REACT_93816 "glyoxylate + alanine => glycine + pyruvate [peroxisome], Oryza sativa"
xref: Reactome:REACT_98489 "glyoxylate + alanine => glycine + pyruvate [peroxisome], Sus scrofa"
xref: Reactome:REACT_98544 "glyoxylate + alanine => glycine + pyruvate [peroxisome], Gallus gallus"
xref: Reactome:REACT_99201 "glyoxylate + alanine => glycine + pyruvate [peroxisome], Arabidopsis thaliana"
xref: Reactome:REACT_99348 "glyoxylate + alanine => glycine + pyruvate [peroxisome], Taeniopygia guttata"
xref: RHEA:24251
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0008454
name: alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + (N-acetyl-beta-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,4-(N-acetyl-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R." [EC:2.4.1.145]
synonym: "alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.145]
synonym: "alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase activity" EXACT []
synonym: "beta-acetylglucosaminyltransferase IV activity" EXACT [EC:2.4.1.145]
synonym: "GnTIV activity" EXACT [EC:2.4.1.145]
synonym: "N-acetylglucosaminyltransferase IV activity" EXACT [EC:2.4.1.145]
synonym: "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV activity" EXACT [EC:2.4.1.145]
synonym: "UDP-N-acetyl-D-glucosamine:3-[2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl]-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.145]
synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta-4-acetylglucosaminyltransferase IV activity" EXACT [EC:2.4.1.145]
synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase IV" RELATED [EC:2.4.1.145]
xref: EC:2.4.1.145
xref: MetaCyc:2.4.1.145-RXN
xref: Reactome:REACT_25009 "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV, Homo sapiens"
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0008455
name: alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R." [EC:2.4.1.143]
synonym: "acetylglucosaminyltransferase II activity" EXACT [EC:2.4.1.143]
synonym: "alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143]
synonym: "alpha-1,6-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143]
synonym: "alpha-1,6-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" EXACT []
synonym: "GnTII activity" EXACT [EC:2.4.1.143]
synonym: "N-acetylglucosaminyltransferase II activity" EXACT [EC:2.4.1.143]
synonym: "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II activity" EXACT [EC:2.4.1.143]
synonym: "UDP-GlcNAc:mannoside alpha-(1,6) acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143]
synonym: "UDP-GlcNAc:mannoside alpha-1,6 acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143]
synonym: "UDP-N-acetyl-D-glucosamine:6-(alpha-D-mannosyl)-beta-D-mannosyl-glycoprotein 2-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.143]
synonym: "uridine diphosphoacetylglucosamine-alpha-1,6-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143]
synonym: "uridine diphosphoacetylglucosamine-alpha-D-mannoside beta(1,2)-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143]
synonym: "uridine diphosphoacetylglucosamine-alpha-D-mannoside beta-1,2-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143]
synonym: "uridine diphosphoacetylglucosamine-mannoside alpha(1,6)-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143]
synonym: "uridine diphosphoacetylglucosamine-mannoside alpha-1,6-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143]
xref: EC:2.4.1.143
xref: MetaCyc:2.4.1.143-RXN
xref: Reactome:REACT_25253 "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2, Homo sapiens"
xref: RHEA:12944
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0008456
name: alpha-N-acetylgalactosaminidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-alpha-D-galactosaminides." [EC:3.2.1.49]
synonym: "alpha-acetylgalactosaminidase activity" EXACT [EC:3.2.1.49]
synonym: "alpha-galactosidase B activity" RELATED [EC:3.2.1.49]
synonym: "alpha-N-acetyl-D-galactosaminide N-acetylgalactosaminohydrolase activity" EXACT [EC:3.2.1.49]
synonym: "alpha-NAGA activity" EXACT [EC:3.2.1.49]
synonym: "N-acetyl-alpha-D-galactosaminidase activity" EXACT [EC:3.2.1.49]
synonym: "N-acetyl-alpha-galactosaminidase activity" EXACT [EC:3.2.1.49]
xref: EC:3.2.1.49
xref: MetaCyc:3.2.1.49-RXN
is_a: GO:0015929 ! hexosaminidase activity

[Term]
id: GO:0008457
name: beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide = UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide." [EC:2.4.1.163]
synonym: "poly-N-acetyllactosamine extension enzyme activity" BROAD [EC:2.4.1.163]
synonym: "UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide beta-1,3-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.163]
synonym: "uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->3-acetylglucosaminyltransferase" BROAD [EC:2.4.1.163]
xref: EC:2.4.1.163
xref: MetaCyc:2.4.1.163-RXN
xref: RHEA:23007
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0008458
name: carnitine O-octanoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-carnitine + octanoyl-CoA = (S)-octanoylcarnitine + CoA." [EC:2.3.1.137, RHEA:17180]
synonym: "carnitine medium-chain acyltransferase activity" EXACT [EC:2.3.1.137]
synonym: "easily solubilized mitochondrial carnitine palmitoyltransferase" NARROW [EC:2.3.1.137]
synonym: "medium-chain/long-chain carnitine acyltransferase activity" EXACT [EC:2.3.1.137]
synonym: "octanoyl-CoA:L-carnitine O-octanoyltransferase activity" EXACT [EC:2.3.1.137]
synonym: "overt mitochondrial carnitine palmitoyltransferase" NARROW [EC:2.3.1.137]
xref: EC:2.3.1.137
xref: KEGG:R03779
xref: MetaCyc:CARNITINE-O-OCTANOYLTRANSFERASE-RXN
xref: Reactome:REACT_100687 "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH, Taeniopygia guttata"
xref: Reactome:REACT_101040 "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH, Sus scrofa"
xref: Reactome:REACT_102950 "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH, Bos taurus"
xref: Reactome:REACT_106705 "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH, Canis familiaris"
xref: Reactome:REACT_16985 "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH, Homo sapiens"
xref: Reactome:REACT_29860 "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH, Danio rerio"
xref: Reactome:REACT_41505 "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH, Rattus norvegicus"
xref: Reactome:REACT_76943 "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH, Xenopus tropicalis"
xref: Reactome:REACT_78846 "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH, Gallus gallus"
xref: Reactome:REACT_86950 "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH, Drosophila melanogaster"
xref: Reactome:REACT_90278 "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH, Mus musculus"
xref: Reactome:REACT_91777 "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH, Caenorhabditis elegans"
xref: RHEA:17180
is_a: GO:0016406 ! carnitine O-acyltransferase activity
is_a: GO:0016414 ! O-octanoyltransferase activity

[Term]
id: GO:0008459
name: chondroitin 6-sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate." [EC:2.8.2.17]
synonym: "3'-phosphoadenosine 5'-phosphosulfate (PAPS):chondroitin sulfate sulfotransferase activity" EXACT [EC:2.8.2.17]
synonym: "3'-phosphoadenylyl-sulfate:chondroitin 6'-sulfotransferase activity" EXACT [EC:2.8.2.17]
synonym: "chondroitin 6-O-sulfotransferase activity" EXACT [EC:2.8.2.17]
synonym: "chondroitin 6-sulphotransferase activity" EXACT []
synonym: "terminal 6-sulfotransferase activity" EXACT [EC:2.8.2.17]
xref: EC:2.8.2.17
xref: MetaCyc:CHONDROITIN-6-SULFOTRANSFERASE-RXN
xref: RHEA:11111
is_a: GO:0034481 ! chondroitin sulfotransferase activity

[Term]
id: GO:0008460
name: dTDP-glucose 4,6-dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: dTDP-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(2)O." [EC:4.2.1.46, RHEA:17224]
subset: gosubset_prok
synonym: "dTDP-glucose 4,6-hydro-lyase (dTDP-4-dehydro-6-deoxy-D-glucose-forming)" EXACT [EC:4.2.1.46]
synonym: "dTDP-glucose 4,6-hydro-lyase activity" EXACT [EC:4.2.1.46]
synonym: "dTDPglucose 4,6-dehydratase activity" EXACT [EC:4.2.1.46]
synonym: "dTDPglucose 4,6-hydro-lyase activity" EXACT [EC:4.2.1.46]
synonym: "TDP-glucose oxidoreductase activity" EXACT [EC:4.2.1.46]
synonym: "thymidine diphosphoglucose oxidoreductase activity" EXACT [EC:4.2.1.46]
xref: EC:4.2.1.46
xref: KEGG:R06513
xref: MetaCyc:DTDPGLUCDEHYDRAT-RXN
xref: RHEA:17224
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0008462
name: obsolete endopeptidase Clp activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are cleaved, for example, succinyl-Leu-Tyr-NHMec which is cleaved at the Tyr-NHMec bond, and Leu-Tyr-Leu-Tyr-Trp which is cleaved at the second Leu-Typ bond (cleavage of the Tyr-Leu and Tyr-Trp bonds also occurs)." [EC:3.4.21.92]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "ATP-dependent Clp protease" NARROW [EC:3.4.21.92]
synonym: "caseinolytic protease activity" RELATED [EC:3.4.21.92]
synonym: "Clp protease" NARROW [EC:3.4.21.92]
synonym: "ClpP" RELATED [EC:3.4.21.92]
synonym: "endopeptidase Clp activity" EXACT []
synonym: "endopeptidase Ti activity" RELATED [EC:3.4.21.92]
synonym: "protease Ti activity" RELATED [EC:3.4.21.92]
xref: EC:3.4.21.92
xref: MetaCyc:3.4.21.92-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0008463
name: formylmethionine deformylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-formyl-L-methionine + H(2)O = L-methionine + formate." [EC:3.5.1.31, RHEA:17784]
subset: gosubset_prok
synonym: "N-formyl-L-methionine amidohydrolase activity" EXACT [EC:3.5.1.31]
xref: EC:3.5.1.31
xref: KEGG:R00653
xref: MetaCyc:FORMYLMETHIONINE-DEFORMYLASE-RXN
xref: RHEA:17784
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0008464
name: obsolete gamma-glutamyl hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of a gamma-glutamyl bond to release an unsubstituted C-terminal amino acid." [EC:3.4.19.9]
comment: This term was made obsolete because it represents a gene product.
synonym: "carboxypeptidase G activity" BROAD [EC:3.4.19.9]
synonym: "conjugase activity" RELATED [EC:3.4.19.9]
synonym: "folate conjugase activity" RELATED [EC:3.4.19.9]
synonym: "folic acid conjugase activity" EXACT [EC:3.4.19.9]
synonym: "gamma-Glu-X carboxypeptidase activity" EXACT [EC:3.4.19.9]
synonym: "gamma-glutamyl hydrolase activity" EXACT []
synonym: "lysosomal gamma-glutamyl carboxypeptidase activity" NARROW [EC:3.4.19.9]
synonym: "poly(gamma-glutamic acid) endohydrolase activity" EXACT [EC:3.4.19.9]
synonym: "poly(glutamic acid) hydrolase II" RELATED [EC:3.4.19.9]
synonym: "polyglutamate hydrolase activity" EXACT [EC:3.4.19.9]
synonym: "pteroyl-poly-alpha-glutamate hydrolase activity" NARROW [EC:3.4.19.9]
synonym: "pteroyl-poly-gamma-glutamate hydrolase activity" EXACT [EC:3.4.19.9]
synonym: "pteroylpoly-gamma-glutamyl hydrolase activity" EXACT [EC:3.4.19.9]
xref: EC:3.4.19.9
xref: MetaCyc:3.4.19.9-RXN
is_obsolete: true
replaced_by: GO:0008242

[Term]
id: GO:0008465
name: glycerate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-glycerate + NAD+ = hydroxypyruvate + NADH + H+." [EC:1.1.1.29]
subset: gosubset_prok
synonym: "hydroxypyruvate dehydrogenase activity" BROAD [EC:1.1.1.29]
xref: EC:1.1.1.29
xref: MetaCyc:GLYCERATE-DEHYDROGENASE-RXN
xref: RHEA:17908
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008466
name: glycogenin glucosyltransferase activity
namespace: molecular_function
alt_id: GO:0047210
def: "Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin." [EC:2.4.1.186]
synonym: "1,4alpha-glucan-protein synthase (UDP-forming) activity" EXACT []
synonym: "alpha-1,4-glucan-protein synthase (UDP-forming) activity" EXACT []
synonym: "glycogenin activity" RELATED [EC:2.4.1.186]
synonym: "priming glucosyltransferase activity" RELATED [EC:2.4.1.186]
synonym: "UDP-alpha-D-glucose:glycogenin alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.186]
synonym: "UDP-glucose:glycogenin glucosyltransferase activity" EXACT [EC:2.4.1.186]
xref: EC:2.4.1.186
xref: MetaCyc:GLYCOGENIN-GLUCOSYLTRANSFERASE-RXN
xref: Reactome:REACT_102334 "8 UDP-glucose + glycogenin dimer => 8 UDP + {(1,4)-alpha-D-glucosyl}4 glycogenin dimer, Bos taurus"
xref: Reactome:REACT_104634 "8 UDP-glucose + glycogenin dimer => 8 UDP + {(1,4)-alpha-D-glucosyl}4 glycogenin dimer, Canis familiaris"
xref: Reactome:REACT_106182 "8 UDP-glucose + glycogenin dimer => 8 UDP + {(1,4)-alpha-D-glucosyl}4 glycogenin dimer, Gallus gallus"
xref: Reactome:REACT_106555 "8 UDP-glucose + glycogenin dimer => 8 UDP + {(1,4)-alpha-D-glucosyl}4 glycogenin dimer, Caenorhabditis elegans"
xref: Reactome:REACT_108809 "8 UDP-glucose + glycogenin dimer => 8 UDP + {(1,4)-alpha-D-glucosyl}4 glycogenin dimer, Taeniopygia guttata"
xref: Reactome:REACT_113130 "8 UDP-glucose + glycogenin dimer => 8 UDP + {(1,4)-alpha-D-glucosyl}4 glycogenin dimer, Arabidopsis thaliana"
xref: Reactome:REACT_1902 "8 UDP-glucose + glycogenin dimer => 8 UDP + {(1,4)-alpha-D-glucosyl}4 glycogenin dimer, Homo sapiens"
xref: Reactome:REACT_79592 "8 UDP-glucose + glycogenin dimer => 8 UDP + {(1,4)-alpha-D-glucosyl}4 glycogenin dimer, Xenopus tropicalis"
xref: Reactome:REACT_80545 "8 UDP-glucose + glycogenin dimer => 8 UDP + {(1,4)-alpha-D-glucosyl}4 glycogenin dimer, Rattus norvegicus"
xref: Reactome:REACT_83613 "8 UDP-glucose + glycogenin dimer => 8 UDP + {(1,4)-alpha-D-glucosyl}4 glycogenin dimer, Danio rerio"
xref: Reactome:REACT_90813 "8 UDP-glucose + glycogenin dimer => 8 UDP + {(1,4)-alpha-D-glucosyl}4 glycogenin dimer, Oryza sativa"
xref: Reactome:REACT_92882 "8 UDP-glucose + glycogenin dimer => 8 UDP + {(1,4)-alpha-D-glucosyl}4 glycogenin dimer, Mus musculus"
xref: Reactome:REACT_94348 "8 UDP-glucose + glycogenin dimer => 8 UDP + {(1,4)-alpha-D-glucosyl}4 glycogenin dimer, Saccharomyces cerevisiae"
xref: Reactome:REACT_99044 "8 UDP-glucose + glycogenin dimer => 8 UDP + {(1,4)-alpha-D-glucosyl}4 glycogenin dimer, Sus scrofa"
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0008467
name: [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate. The [heparan sulfate]-glucosamine 3-sulfate has a substrate consensus sequence of Glc(N2S>NAc)+/-6S GlcA GlcN2S*+/-6S GlcA>IdoA+/-2S Glc(N2S/NAc)+/-6S." [EC:2.8.2.23]
synonym: "3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase" BROAD [EC:2.8.2.23]
synonym: "3'-phosphoadenylyl-sulfate:heparin-glucosamine 3-O-sulfotransferase activity" EXACT [EC:2.8.2.23]
synonym: "3-OST-1 activity" EXACT [EC:2.8.2.23]
synonym: "glucosaminyl 3-O-sulfotransferase activity" EXACT [EC:2.8.2.23]
synonym: "heparan sulfate D-glucosaminyl 3-O-sulfotransferase activity" EXACT [EC:2.8.2.23]
synonym: "heparin-glucosamine 3-O-sulfotransferase activity" RELATED []
synonym: "heparin-glucosamine 3-O-sulphotransferase activity" RELATED []
synonym: "isoform/isozyme 1 (3-OST-1, HS3ST1)" RELATED [EC:2.8.2.23]
xref: EC:2.8.2.23
xref: MetaCyc:2.8.2.23-RXN
is_a: GO:0034483 ! heparan sulfate sulfotransferase activity

[Term]
id: GO:0008469
name: histone-arginine N-methyltransferase activity
namespace: molecular_function
alt_id: GO:0016276
def: "Catalysis of the reaction: S-adenosyl-L-methionine + (histone)-arginine = S-adenosyl-L-homocysteine + (histone)-N-methyl-arginine." [EC:2.1.1.125]
synonym: "histone methyltransferase activity" BROAD []
synonym: "histone protein methylase activity" EXACT [EC:2.1.1.125]
synonym: "histone protein methylase I" RELATED [EC:2.1.1.125]
synonym: "histone-arginine N-methylase activity" EXACT [GOC:mah]
synonym: "nuclear protein (histone) N-methyltransferase activity" EXACT [EC:2.1.1.125]
synonym: "protein methylase I activity" BROAD [EC:2.1.1.125]
synonym: "S-adenosyl-L-methionine:histone-arginine nomega-methyltransferase activity" EXACT [EC:2.1.1.125]
synonym: "S-adenosyl-L-methionine:histone-arginine omega-N-methyltransferase activity" EXACT [EC:2.1.1.125]
xref: EC:2.1.1.125
xref: MetaCyc:2.1.1.125-RXN
is_a: GO:0016274 ! protein-arginine N-methyltransferase activity
is_a: GO:0042054 ! histone methyltransferase activity
relationship: part_of GO:0034969 ! histone arginine methylation

[Term]
id: GO:0008470
name: isovaleryl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-methylbutanoyl-CoA + ETF = 3-methylbut-2-enoyl-CoA + reduced ETF." [EC:1.3.99.10]
subset: gosubset_prok
synonym: "3-methylbutanoyl-CoA:(acceptor) oxidoreductase activity" EXACT [EC:1.3.99.10]
synonym: "3-methylbutanoyl-CoA:acceptor oxidoreductase activity" EXACT [EC:1.3.99.10]
synonym: "isovaleroyl-coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.10]
synonym: "isovaleryl-coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.10]
xref: EC:1.3.99.10
xref: MetaCyc:ISOVALERYL-COA-FAD-RXN
xref: Reactome:REACT_100290 "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2, Mus musculus"
xref: Reactome:REACT_101943 "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2, Canis familiaris"
xref: Reactome:REACT_109543 "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2, Danio rerio"
xref: Reactome:REACT_1586 "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2, Homo sapiens"
xref: Reactome:REACT_28761 "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2, Caenorhabditis elegans"
xref: Reactome:REACT_29762 "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2, Drosophila melanogaster"
xref: Reactome:REACT_30865 "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2, Gallus gallus"
xref: Reactome:REACT_32004 "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2, Arabidopsis thaliana"
xref: Reactome:REACT_33419 "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2, Xenopus tropicalis"
xref: Reactome:REACT_34628 "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2, Taeniopygia guttata"
xref: Reactome:REACT_77254 "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2, Bos taurus"
xref: Reactome:REACT_78980 "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2, Oryza sativa"
xref: Reactome:REACT_80012 "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2, Rattus norvegicus"
xref: Reactome:REACT_89485 "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2, Sus scrofa"
xref: Reactome:REACT_89850 "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2, Dictyostelium discoideum"
xref: RHEA:12279
is_a: GO:0003995 ! acyl-CoA dehydrogenase activity

[Term]
id: GO:0008471
name: obsolete laccase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O." [EC:1.10.3.2]
synonym: "benzenediol:oxygen oxidoreductase activity" RELATED [EC:1.10.3.2]
synonym: "laccase activity" EXACT []
synonym: "p-diphenol oxidase activity" RELATED [EC:1.10.3.2]
synonym: "urishiol oxidase activity" RELATED [EC:1.10.3.2]
synonym: "urushiol oxidase activity" RELATED [EC:1.10.3.2]
is_obsolete: true
replaced_by: GO:0016682

[Term]
id: GO:0008472
name: obsolete metallocarboxypeptidase D activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Function is activated by Co2+; inhibited by guanidinoethylmercaptosuccinic acid." [EC:3.4.17.22]
comment: This term was made obsolete because it represents a gene product.
synonym: "carboxypeptidase D (cattle, human, mouse, rat)" RELATED [EC:3.4.17.22]
synonym: "gp180 (duck)" RELATED [EC:3.4.17.22]
synonym: "metallocarboxypeptidase D activity" EXACT []
xref: EC:3.4.17.22
xref: MetaCyc:3.4.17.22-RXN
is_obsolete: true
replaced_by: GO:0004181

[Term]
id: GO:0008473
name: ornithine cyclodeaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-ornithine = L-proline + NH(4)(+)." [EC:4.3.1.12, RHEA:24371]
subset: gosubset_prok
synonym: "L-ornithine ammonia-lyase (cyclizing)" EXACT [EC:4.3.1.12]
synonym: "L-ornithine ammonia-lyase (cyclizing; L-proline-forming)" EXACT [EC:4.3.1.12]
synonym: "OCD activity" EXACT [EC:4.3.1.12]
synonym: "ornithine cyclase (deaminating) activity" EXACT [EC:4.3.1.12]
synonym: "ornithine cyclase activity" EXACT [EC:4.3.1.12]
xref: EC:4.3.1.12
xref: KEGG:R00671
xref: MetaCyc:ORNITHINE-CYCLODEAMINASE-RXN
xref: RHEA:24371
is_a: GO:0016841 ! ammonia-lyase activity
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0008474
name: palmitoyl-(protein) hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein." [EC:3.1.2.22]
subset: goslim_chembl
synonym: "palmitoyl-[protein] hydrolase" BROAD [EC:3.1.2.22]
synonym: "palmitoyl-protein hydrolase activity" EXACT []
synonym: "palmitoyl-protein thioesterase activity" EXACT []
synonym: "palmitoyl-protein thiolesterase activity" EXACT []
xref: EC:3.1.2.22
xref: MetaCyc:3.1.2.22-RXN
xref: Reactome:REACT_106471 "depalmitoylation of eNOS, Rattus norvegicus"
xref: Reactome:REACT_106834 "depalmitoylation of eNOS, Bos taurus"
xref: Reactome:REACT_12463 "depalmitoylation of eNOS, Homo sapiens"
xref: Reactome:REACT_85636 "depalmitoylation of eNOS, Canis familiaris"
xref: Reactome:REACT_88738 "depalmitoylation of eNOS, Xenopus tropicalis"
xref: Reactome:REACT_95011 "depalmitoylation of eNOS, Mus musculus"
xref: Reactome:REACT_97399 "depalmitoylation of eNOS, Sus scrofa"
is_a: GO:0016790 ! thiolester hydrolase activity
is_a: GO:0098599 ! palmitoyl hydrolase activity

[Term]
id: GO:0008475
name: procollagen-lysine 5-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: procollagen L-lysine + 2-oxoglutarate + O2 = procollagen 5-hydroxy-L-lysine + succinate + CO2." [EC:1.14.11.4]
synonym: "collagen lysine hydroxylase activity" EXACT [EC:1.14.11.4]
synonym: "lysine hydroxylase activity" BROAD [EC:1.14.11.4]
synonym: "lysine,2-oxoglutarate 5-dioxygenase activity" BROAD [EC:1.14.11.4]
synonym: "lysine-2-oxoglutarate dioxygenase activity" BROAD [EC:1.14.11.4]
synonym: "lysyl hydroxylase activity" BROAD [EC:1.14.11.4]
synonym: "lysylprotocollagen dioxygenase activity" EXACT [EC:1.14.11.4]
synonym: "procollagen-L-lysine,2-oxoglutarate:oxygen oxidoreductase (5-hydroxylating)" EXACT [EC:1.14.11.4]
synonym: "procollagen-lysine,2-oxoglutarate 5-dioxygenase activity" EXACT [EC:1.14.11.4]
synonym: "protocollagen lysine dioxygenase activity" EXACT [EC:1.14.11.4]
synonym: "protocollagen lysine hydroxylase activity" EXACT [EC:1.14.11.4]
synonym: "protocollagen lysyl hydroxylase activity" EXACT [EC:1.14.11.4]
xref: EC:1.14.11.4
xref: MetaCyc:PROCOLLAGEN-LYSINE-5-DIOXYGENASE-RXN
is_a: GO:0070815 ! peptidyl-lysine 5-dioxygenase activity

[Term]
id: GO:0008476
name: protein-tyrosine sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate." [EC:2.8.2.20]
subset: goslim_chembl
synonym: "3'-phosphoadenylyl-sulfate:protein-tyrosine O-sulfotransferase activity" EXACT [EC:2.8.2.20]
synonym: "protein-tyrosine sulphotransferase activity" EXACT []
synonym: "tyrosylprotein sulfotransferase activity" EXACT [EC:2.8.2.20]
xref: EC:2.8.2.20
xref: MetaCyc:PROTEIN-TYROSINE-SULFOTRANSFERASE-RXN
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0008477
name: purine nucleosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a N-D-ribosylpurine + H2O = a purine + D-ribose." [EC:3.2.2.1]
subset: gosubset_prok
synonym: "IAG-NH activity" RELATED [EC:3.2.2.1]
synonym: "IAG-nucleoside hydrolase activity" RELATED [EC:3.2.2.1]
synonym: "inosine-adenosine-guanosine preferring nucleoside hydrolase activity" NARROW [EC:3.2.2.1]
synonym: "N-D-ribosylpurine ribohydrolase activity" EXACT [EC:3.2.2.1]
synonym: "N-ribosyl purine ribohydrolase activity" EXACT [EC:3.2.2.1]
synonym: "nucleosidase activity" BROAD [EC:3.2.2.1]
synonym: "nucleosidase g activity" NARROW [EC:3.2.2.1]
synonym: "nucleoside hydrolase activity" BROAD [EC:3.2.2.1]
synonym: "purine beta-ribosidase activity" EXACT [EC:3.2.2.1]
synonym: "purine nucleosidase reaction" EXACT []
synonym: "purine nucleoside hydrolase activity" EXACT [EC:3.2.2.1]
synonym: "purine ribonucleosidase activity" EXACT [EC:3.2.2.1]
synonym: "purine-nucleoside ribohydrolase activity" EXACT [EC:3.2.2.1]
synonym: "purine-specific nucleoside N-ribohydrolase activity" EXACT [EC:3.2.2.1]
synonym: "ribonucleoside hydrolase activity" EXACT [EC:3.2.2.1]
xref: EC:3.2.2.1
xref: MetaCyc:PURINE-NUCLEOSIDASE-RXN
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0008478
name: pyridoxal kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + pyridoxal = ADP + pyridoxal 5'-phosphate." [EC:2.7.1.35]
subset: gosubset_prok
synonym: "ATP:pyridoxal 5'-phosphotransferase activity" EXACT [EC:2.7.1.35]
synonym: "pyridoxal 5-phosphate-kinase activity" EXACT [EC:2.7.1.35]
synonym: "pyridoxal kinase (phosphorylating)" EXACT [EC:2.7.1.35]
synonym: "pyridoxal phosphokinase activity" EXACT [EC:2.7.1.35]
synonym: "pyridoxamine kinase activity" RELATED [EC:2.7.1.35]
synonym: "pyridoxine kinase activity" RELATED [EC:2.7.1.35]
synonym: "vitamin B(6) kinase activity" RELATED [EC:2.7.1.35]
synonym: "vitamin B6 kinase activity" RELATED [EC:2.7.1.35]
xref: EC:2.7.1.35
xref: MetaCyc:PYRIDOXKIN-RXN
xref: Reactome:REACT_25109 "Pyridoxine is phosphorylated, Homo sapiens"
xref: Reactome:REACT_25295 "PLP results from phosphorylation of pyridoxal, Homo sapiens"
xref: Reactome:REACT_25323 "Pyridoxamine is phosphorylated, Homo sapiens"
xref: RHEA:10227
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0008479
name: queuine tRNA-ribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: tRNA guanine + queuine = tRNA queuine + guanine." [EC:2.4.2.29]
subset: gosubset_prok
synonym: "[tRNA]-guanine:queuine tRNA-D-ribosyltransferase activity" EXACT [EC:2.4.2.29]
synonym: "guanine insertion enzyme activity" RELATED [EC:2.4.2.29]
synonym: "guanine, queuine-tRNA transglycosylase activity" EXACT [EC:2.4.2.29]
synonym: "Q-insertase activity" EXACT [EC:2.4.2.29]
synonym: "queuine transfer ribonucleate ribosyltransferase activity" EXACT [EC:2.4.2.29]
synonym: "transfer ribonucleate glycosyltransferase activity" EXACT [EC:2.4.2.29]
synonym: "tRNA guanine transglycosidase activity" EXACT [EC:2.4.2.29]
synonym: "tRNA transglycosylase activity" EXACT [EC:2.4.2.29]
synonym: "tRNA-guanine transglycosylase activity" EXACT [EC:2.4.2.29]
xref: EC:2.4.2.29
xref: MetaCyc:QUEUOSINE-TRNA-RIBOSYLTRANSFERASE-RXN
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0008480
name: sarcosine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: sarcosine + H2O + electron-transfer flavoprotein = glycine + formaldehyde + reduced electron-transfer flavoprotein." [EC:1.5.8.3, RHEA:19796]
comment: Note that this was EC:1.5.99.1.
subset: gosubset_prok
synonym: "monomethylglycine dehydrogenase activity" EXACT [EC:1.5.8.3]
synonym: "sarcosine N-demethylase activity" EXACT [EC:1.5.8.3]
synonym: "sarcosine:(acceptor) oxidoreductase (demethylating)" EXACT [EC:1.5.8.3]
synonym: "sarcosine:acceptor oxidoreductase (demethylating)" EXACT [EC:1.5.8.3]
xref: EC:1.5.8.3
xref: KEGG:R00611
xref: MetaCyc:SARCOSINE-DEHYDROGENASE-RXN
xref: RHEA:19796
is_a: GO:0046997 ! oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor

[Term]
id: GO:0008481
name: sphinganine kinase activity
namespace: molecular_function
alt_id: GO:0001728
def: "Catalysis of the reaction: ATP + sphinganine = ADP + sphinganine 1-phosphate." [EC:2.7.1.91]
synonym: "ATP:sphinganine 1-phosphotransferase activity" EXACT [EC:2.7.1.91]
synonym: "dihydrosphingosine kinase (phosphorylating)" EXACT [EC:2.7.1.91]
synonym: "dihydrosphingosine kinase activity" EXACT [EC:2.7.1.91]
synonym: "sphingosine kinase (phosphorylating)" EXACT [EC:2.7.1.91]
synonym: "sphingosine kinase activity" RELATED []
xref: EC:2.7.1.91
xref: MetaCyc:SPHINGANINE-KINASE-RXN
xref: Reactome:REACT_107556 "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP, Schizosaccharomyces pombe"
xref: Reactome:REACT_112755 "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP, Caenorhabditis elegans"
xref: Reactome:REACT_115985 "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP, Gallus gallus"
xref: Reactome:REACT_19412 "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP, Homo sapiens"
xref: Reactome:REACT_30153 "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP, Danio rerio"
xref: Reactome:REACT_30536 "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP, Taeniopygia guttata"
xref: Reactome:REACT_32874 "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP, Rattus norvegicus"
xref: Reactome:REACT_33569 "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP, Gallus gallus"
xref: Reactome:REACT_81286 "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP, Sus scrofa"
xref: Reactome:REACT_82292 "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP, Dictyostelium discoideum"
xref: Reactome:REACT_83151 "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP, Bos taurus"
xref: Reactome:REACT_84912 "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP, Mus musculus"
xref: Reactome:REACT_86550 "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP, Arabidopsis thaliana"
xref: Reactome:REACT_88225 "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP, Xenopus tropicalis"
xref: Reactome:REACT_92421 "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP, Oryza sativa"
xref: Reactome:REACT_92517 "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP, Canis familiaris"
xref: Reactome:REACT_93076 "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP, Drosophila melanogaster"
xref: Reactome:REACT_93406 "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP, Saccharomyces cerevisiae"
xref: RHEA:15468
is_a: GO:0001727 ! lipid kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0008482
name: sulfite oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + O(2) + sulfite = H(2)O(2) + H(+) + sulfate." [EC:1.8.3.1, RHEA:24603]
subset: gosubset_prok
synonym: "sulfite:oxygen oxidoreductase activity" EXACT [EC:1.8.3.1]
synonym: "sulphite oxidase activity" EXACT []
xref: EC:1.8.3.1
xref: KEGG:R00533
xref: MetaCyc:PWY-5326
xref: MetaCyc:SULFITE-OXIDASE-RXN
xref: Reactome:REACT_116081 "Sulfite is oxidized to sulfate, Homo sapiens"
xref: RHEA:24603
is_a: GO:0016670 ! oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor

[Term]
id: GO:0008483
name: transaminase activity
namespace: molecular_function
def: "Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732]
subset: gosubset_prok
synonym: "aminotransferase activity" EXACT []
xref: EC:2.6.1
xref: Reactome:REACT_75811 "Transamination of MOB to methionine, Homo sapiens"
is_a: GO:0016769 ! transferase activity, transferring nitrogenous groups

[Term]
id: GO:0008484
name: sulfuric ester hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of any sulfuric ester bond, any ester formed from sulfuric acid, O=SO(OH)2." [GOC:ai]
subset: gosubset_prok
synonym: "sulfatase activity" EXACT []
synonym: "sulphuric ester hydrolase activity" EXACT []
xref: EC:3.1.6
xref: MetaCyc:ARYLSULFAT-RXN
is_a: GO:0016788 ! hydrolase activity, acting on ester bonds

[Term]
id: GO:0008486
name: diphosphoinositol-polyphosphate diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: diphospho-myo-inositol polyphosphate + H2O = myo-inositol polyphosphate + phosphate." [EC:3.6.1.52]
synonym: "diphospho-myo-inositol-polyphosphate diphosphohydrolase activity" EXACT [EC:3.6.1.52]
synonym: "diphosphoinositol polyphosphate phosphohydrolase activity" EXACT []
synonym: "diphosphoinositol-polyphosphate phosphohydrolase activity" EXACT [EC:3.6.1.52]
synonym: "DIPP activity" EXACT [EC:3.6.1.52]
xref: EC:3.6.1.52
xref: KEGG:R05777
xref: MetaCyc:3.6.1.52-RXN
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0008487
name: obsolete prenyl-dependent CAAX protease activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "prenyl-dependent CAAX protease activity" EXACT []
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0008488
name: gamma-glutamyl carboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: peptidyl-glutamate + reduced vitamin K + CO2 + O2 = peptidyl-gamma-carboxyglutamate + vitamin K epoxide." [PMID:18374194]
subset: gosubset_prok
xref: EC:4.1.1.-
xref: Reactome:REACT_100246 "pro-protein C, uncarboxylated + 8 CO2 + 8 O2 + 8 vitamin K hydroquinone -> pro-protein C + 8 H2O + 8 vitamin K epoxide, Mus musculus"
xref: Reactome:REACT_101542 "pro-protein C, uncarboxylated + 8 CO2 + 8 O2 + 8 vitamin K hydroquinone -> pro-protein C + 8 H2O + 8 vitamin K epoxide, Xenopus tropicalis"
xref: Reactome:REACT_101915 "pro-factor IX, uncarboxylated + 12 CO2 + 12 O2 + 12 vitamin K hydroquinone -> pro-factor IX + 12 H2O + 12 vitamin K epoxide, Danio rerio"
xref: Reactome:REACT_103318 "pro-protein C, uncarboxylated + 8 CO2 + 8 O2 + 8 vitamin K hydroquinone -> pro-protein C + 8 H2O + 8 vitamin K epoxide, Bos taurus"
xref: Reactome:REACT_103605 "pro-factor VII, uncarboxylated + 10 CO2 + 10 O2 + 10 vitamin K hydroquinone -> pro-factor VII + 10 H2O + 10 vitamin K epoxide, Danio rerio"
xref: Reactome:REACT_103968 "pro-GAS6, uncarboxylated + 11 CO2 + 11 O2 + 11 vitamin K hydroquinone -> pro-GAS6 + 11 H2O + 11 vitamin K epoxide, Rattus norvegicus"
xref: Reactome:REACT_104712 "pro-prothrombin, uncarboxylated + 10 CO2 + 10 O2 + 10 vitamin K hydroquinone -> pro-prothrombin + 10 H2O + 10 vitamin K epoxide, Danio rerio"
xref: Reactome:REACT_105999 "pro-factor IX, uncarboxylated + 12 CO2 + 12 O2 + 12 vitamin K hydroquinone -> pro-factor IX + 12 H2O + 12 vitamin K epoxide, Xenopus tropicalis"
xref: Reactome:REACT_106659 "pro-factor X, uncarboxylated + 11 CO2 + 11 O2 + 11 vitamin K hydroquinone -> pro-factor X + 11 H2O + 11 vitamin K epoxide, Rattus norvegicus"
xref: Reactome:REACT_107933 "pro-factor VII, uncarboxylated + 10 CO2 + 10 O2 + 10 vitamin K hydroquinone -> pro-factor VII + 10 H2O + 10 vitamin K epoxide, Canis familiaris"
xref: Reactome:REACT_109024 "pro-factor X, uncarboxylated + 11 CO2 + 11 O2 + 11 vitamin K hydroquinone -> pro-factor X + 11 H2O + 11 vitamin K epoxide, Danio rerio"
xref: Reactome:REACT_109990 "pro-prothrombin, uncarboxylated + 10 CO2 + 10 O2 + 10 vitamin K hydroquinone -> pro-prothrombin + 10 H2O + 10 vitamin K epoxide, Rattus norvegicus"
xref: Reactome:REACT_110106 "pro-protein Z, uncarboxylated + 13 CO2 + 13 O2 + 13 vitamin K hydroquinone -> pro-protein Z + 13 H2O + 13 vitamin K epoxide, Rattus norvegicus"
xref: Reactome:REACT_110360 "pro-prothrombin, uncarboxylated + 10 CO2 + 10 O2 + 10 vitamin K hydroquinone -> pro-prothrombin + 10 H2O + 10 vitamin K epoxide, Xenopus tropicalis"
xref: Reactome:REACT_124 "pro-protein Z, uncarboxylated + 13 CO2 + 13 O2 + 13 vitamin K hydroquinone -> pro-protein Z + 13 H2O + 13 vitamin K epoxide, Homo sapiens"
xref: Reactome:REACT_1290 "pro-GAS6, uncarboxylated + 11 CO2 + 11 O2 + 11 vitamin K hydroquinone -> pro-GAS6 + 11 H2O + 11 vitamin K epoxide, Homo sapiens"
xref: Reactome:REACT_1307 "pro-protein S, uncarboxylated + 11 CO2 + 11 O2 + 11 vitamin K hydroquinone -> pro-protein S + 11 H2O + 11 vitamin K epoxide, Homo sapiens"
xref: Reactome:REACT_1565 "pro-factor X, uncarboxylated + 11 CO2 + 11 O2 + 11 vitamin K hydroquinone -> pro-factor X + 11 H2O + 11 vitamin K epoxide, Homo sapiens"
xref: Reactome:REACT_1969 "pro-factor VII, uncarboxylated + 10 CO2 + 10 O2 + 10 vitamin K hydroquinone -> pro-factor VII + 10 H2O + 10 vitamin K epoxide, Homo sapiens"
xref: Reactome:REACT_2045 "pro-factor IX, uncarboxylated + 12 CO2 + 12 O2 + 12 vitamin K hydroquinone -> pro-factor IX + 12 H2O + 12 vitamin K epoxide, Homo sapiens"
xref: Reactome:REACT_28330 "pro-protein Z, uncarboxylated + 13 CO2 + 13 O2 + 13 vitamin K hydroquinone -> pro-protein Z + 13 H2O + 13 vitamin K epoxide, Xenopus tropicalis"
xref: Reactome:REACT_28759 "pro-factor X, uncarboxylated + 11 CO2 + 11 O2 + 11 vitamin K hydroquinone -> pro-factor X + 11 H2O + 11 vitamin K epoxide, Mus musculus"
xref: Reactome:REACT_29111 "pro-GAS6, uncarboxylated + 11 CO2 + 11 O2 + 11 vitamin K hydroquinone -> pro-GAS6 + 11 H2O + 11 vitamin K epoxide, Xenopus tropicalis"
xref: Reactome:REACT_29238 "pro-prothrombin, uncarboxylated + 10 CO2 + 10 O2 + 10 vitamin K hydroquinone -> pro-prothrombin + 10 H2O + 10 vitamin K epoxide, Canis familiaris"
xref: Reactome:REACT_31481 "pro-factor VII, uncarboxylated + 10 CO2 + 10 O2 + 10 vitamin K hydroquinone -> pro-factor VII + 10 H2O + 10 vitamin K epoxide, Rattus norvegicus"
xref: Reactome:REACT_32143 "pro-protein S, uncarboxylated + 11 CO2 + 11 O2 + 11 vitamin K hydroquinone -> pro-protein S + 11 H2O + 11 vitamin K epoxide, Canis familiaris"
xref: Reactome:REACT_32849 "pro-protein S, uncarboxylated + 11 CO2 + 11 O2 + 11 vitamin K hydroquinone -> pro-protein S + 11 H2O + 11 vitamin K epoxide, Mus musculus"
xref: Reactome:REACT_34212 "pro-prothrombin, uncarboxylated + 10 CO2 + 10 O2 + 10 vitamin K hydroquinone -> pro-prothrombin + 10 H2O + 10 vitamin K epoxide, Mus musculus"
xref: Reactome:REACT_77382 "pro-protein Z, uncarboxylated + 13 CO2 + 13 O2 + 13 vitamin K hydroquinone -> pro-protein Z + 13 H2O + 13 vitamin K epoxide, Bos taurus"
xref: Reactome:REACT_78165 "pro-factor IX, uncarboxylated + 12 CO2 + 12 O2 + 12 vitamin K hydroquinone -> pro-factor IX + 12 H2O + 12 vitamin K epoxide, Rattus norvegicus"
xref: Reactome:REACT_78190 "pro-GAS6, uncarboxylated + 11 CO2 + 11 O2 + 11 vitamin K hydroquinone -> pro-GAS6 + 11 H2O + 11 vitamin K epoxide, Mus musculus"
xref: Reactome:REACT_78547 "pro-GAS6, uncarboxylated + 11 CO2 + 11 O2 + 11 vitamin K hydroquinone -> pro-GAS6 + 11 H2O + 11 vitamin K epoxide, Canis familiaris"
xref: Reactome:REACT_80326 "pro-protein C, uncarboxylated + 8 CO2 + 8 O2 + 8 vitamin K hydroquinone -> pro-protein C + 8 H2O + 8 vitamin K epoxide, Danio rerio"
xref: Reactome:REACT_80400 "pro-factor VII, uncarboxylated + 10 CO2 + 10 O2 + 10 vitamin K hydroquinone -> pro-factor VII + 10 H2O + 10 vitamin K epoxide, Mus musculus"
xref: Reactome:REACT_82276 "pro-factor X, uncarboxylated + 11 CO2 + 11 O2 + 11 vitamin K hydroquinone -> pro-factor X + 11 H2O + 11 vitamin K epoxide, Bos taurus"
xref: Reactome:REACT_82349 "pro-protein Z, uncarboxylated + 13 CO2 + 13 O2 + 13 vitamin K hydroquinone -> pro-protein Z + 13 H2O + 13 vitamin K epoxide, Danio rerio"
xref: Reactome:REACT_82360 "pro-protein S, uncarboxylated + 11 CO2 + 11 O2 + 11 vitamin K hydroquinone -> pro-protein S + 11 H2O + 11 vitamin K epoxide, Danio rerio"
xref: Reactome:REACT_83204 "pro-protein C, uncarboxylated + 8 CO2 + 8 O2 + 8 vitamin K hydroquinone -> pro-protein C + 8 H2O + 8 vitamin K epoxide, Rattus norvegicus"
xref: Reactome:REACT_83358 "pro-prothrombin, uncarboxylated + 10 CO2 + 10 O2 + 10 vitamin K hydroquinone -> pro-prothrombin + 10 H2O + 10 vitamin K epoxide, Bos taurus"
xref: Reactome:REACT_83960 "pro-factor X, uncarboxylated + 11 CO2 + 11 O2 + 11 vitamin K hydroquinone -> pro-factor X + 11 H2O + 11 vitamin K epoxide, Xenopus tropicalis"
xref: Reactome:REACT_83967 "pro-factor IX, uncarboxylated + 12 CO2 + 12 O2 + 12 vitamin K hydroquinone -> pro-factor IX + 12 H2O + 12 vitamin K epoxide, Canis familiaris"
xref: Reactome:REACT_84836 "pro-protein S, uncarboxylated + 11 CO2 + 11 O2 + 11 vitamin K hydroquinone -> pro-protein S + 11 H2O + 11 vitamin K epoxide, Bos taurus"
xref: Reactome:REACT_85422 "pro-protein C, uncarboxylated + 8 CO2 + 8 O2 + 8 vitamin K hydroquinone -> pro-protein C + 8 H2O + 8 vitamin K epoxide, Canis familiaris"
xref: Reactome:REACT_86864 "pro-GAS6, uncarboxylated + 11 CO2 + 11 O2 + 11 vitamin K hydroquinone -> pro-GAS6 + 11 H2O + 11 vitamin K epoxide, Bos taurus"
xref: Reactome:REACT_88204 "pro-GAS6, uncarboxylated + 11 CO2 + 11 O2 + 11 vitamin K hydroquinone -> pro-GAS6 + 11 H2O + 11 vitamin K epoxide, Danio rerio"
xref: Reactome:REACT_88424 "pro-factor VII, uncarboxylated + 10 CO2 + 10 O2 + 10 vitamin K hydroquinone -> pro-factor VII + 10 H2O + 10 vitamin K epoxide, Bos taurus"
xref: Reactome:REACT_903 "pro-prothrombin, uncarboxylated + 10 CO2 + 10 O2 + 10 vitamin K hydroquinone -> pro-prothrombin + 10 H2O + 10 vitamin K epoxide, Homo sapiens"
xref: Reactome:REACT_90478 "pro-factor VII, uncarboxylated + 10 CO2 + 10 O2 + 10 vitamin K hydroquinone -> pro-factor VII + 10 H2O + 10 vitamin K epoxide, Xenopus tropicalis"
xref: Reactome:REACT_913 "pro-protein C, uncarboxylated + 8 CO2 + 8 O2 + 8 vitamin K hydroquinone -> pro-protein C + 8 H2O + 8 vitamin K epoxide, Homo sapiens"
xref: Reactome:REACT_91531 "pro-protein S, uncarboxylated + 11 CO2 + 11 O2 + 11 vitamin K hydroquinone -> pro-protein S + 11 H2O + 11 vitamin K epoxide, Xenopus tropicalis"
xref: Reactome:REACT_91904 "pro-factor IX, uncarboxylated + 12 CO2 + 12 O2 + 12 vitamin K hydroquinone -> pro-factor IX + 12 H2O + 12 vitamin K epoxide, Bos taurus"
xref: Reactome:REACT_93248 "pro-factor X, uncarboxylated + 11 CO2 + 11 O2 + 11 vitamin K hydroquinone -> pro-factor X + 11 H2O + 11 vitamin K epoxide, Canis familiaris"
xref: Reactome:REACT_93660 "pro-protein Z, uncarboxylated + 13 CO2 + 13 O2 + 13 vitamin K hydroquinone -> pro-protein Z + 13 H2O + 13 vitamin K epoxide, Mus musculus"
xref: Reactome:REACT_96072 "pro-factor IX, uncarboxylated + 12 CO2 + 12 O2 + 12 vitamin K hydroquinone -> pro-factor IX + 12 H2O + 12 vitamin K epoxide, Mus musculus"
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0008489
name: UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-D-galactose + a glucosylceramide = a lactosylceramide + uridine-5'-diphosphate. The glucosylceramide has sphinganine as the long chain base." [MetaCyc:RXN-10764, PMID:9593693]
synonym: "LacCer synthase activity" EXACT []
synonym: "lactosylceramide synthase activity" EXACT []
synonym: "UDP-galactose glucosylceramide beta-1,4-galactosyltransferase activity" EXACT []
xref: MetaCyc:RXN-10764
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0008490
name: arsenite secondary active transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0008491
def: "Catalysis of the transfer of arsenite from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:jl]
subset: gosubset_prok
synonym: "arsenite porter activity" RELATED []
is_a: GO:0015105 ! arsenite transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0008492
name: obsolete cAMP generating peptide activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it describes a gene product.
synonym: "cAMP generating peptide activity" EXACT []
synonym: "cyclic AMP generating peptide activity" EXACT []
is_obsolete: true
consider: GO:0004016
consider: GO:0005179
consider: GO:0046058

[Term]
id: GO:0008493
name: tetracycline transporter activity
namespace: molecular_function
def: "Enables the directed movement of tetracycline into, out of or within a cell, or between cells. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles)." [CHEBI:27902, GOC:curators]
subset: gosubset_prok
synonym: "tetracyclin transporter activity" EXACT []
is_a: GO:0042895 ! antibiotic transporter activity
relationship: part_of GO:0015904 ! tetracycline transport

[Term]
id: GO:0008494
name: translation activator activity
namespace: molecular_function
def: "Any of a group of soluble proteins functioning in the activation of ribosome-mediated translation of mRNA into a polypeptide." [GOC:ai]
is_a: GO:0090079 ! translation regulator activity, nucleic acid binding
relationship: part_of GO:0045727 ! positive regulation of translation

[Term]
id: GO:0008495
name: protoheme IX farnesyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: protoheme IX + (2E,6E)-farnesyl diphosphate + H2O = heme o + diphosphate." [MetaCyc:HEMEOSYN-RXN]
subset: gosubset_prok
synonym: "haem O synthase activity" EXACT []
synonym: "heme A:farnesyltransferase activity" EXACT [PMID:9177788]
synonym: "heme O synthase activity" EXACT []
synonym: "protohaem IX farnesyltransferase activity" EXACT []
xref: EC:2.5.1.-
xref: MetaCyc:HEMEOSYN-RXN
xref: RHEA:28073
is_a: GO:0004311 ! farnesyltranstransferase activity

[Term]
id: GO:0008496
name: mannan endo-1,6-alpha-mannosidase activity
namespace: molecular_function
def: "Catalysis of the random hydrolysis of (1->6)-alpha-D-mannosidic linkages in unbranched (1->6)-mannans." [EC:3.2.1.101]
synonym: "1,6-alpha-D-mannan mannanohydrolase activity" EXACT [EC:3.2.1.101]
synonym: "1,6-beta-D-mannan mannanohydrolase activity" EXACT [EC:3.2.1.101]
synonym: "endo-1,6-beta-mannanase activity" EXACT [EC:3.2.1.101]
synonym: "endo-alpha-1->6-D-mannanase activity" EXACT [EC:3.2.1.101]
synonym: "endo-alpha-D-mannosidase activity" EXACT []
synonym: "exo-1,6-beta-mannanase activity" EXACT [EC:3.2.1.101]
synonym: "mannan endo-1,6-beta-mannosidase activity" EXACT [EC:3.2.1.101]
xref: EC:3.2.1.101
xref: MetaCyc:3.2.1.101-RXN
is_a: GO:0004559 ! alpha-mannosidase activity

[Term]
id: GO:0008498
name: obsolete phospholipid scrambling
namespace: molecular_function
def: "OBSOLETE. The trans-bilayer migration of phospholipids accelerated by a phospholipid scramblase upon binding calcium ions." [OMIM:604170]
comment: This term was made obsolete because it represents a biological process and not a molecular function.
synonym: "phospholipid scrambling" EXACT []
is_obsolete: true
replaced_by: GO:0017121

[Term]
id: GO:0008499
name: UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-galactose + N-acetylglucosamine = galactose-beta-1,3-N-acetylglucosamine + UDP." [PMID:10212226]
synonym: "beta-1,3-GalTase activity" BROAD []
synonym: "beta3Gal-Ts activity" BROAD []
synonym: "UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase activity" EXACT []
synonym: "UDP-galactose beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity" EXACT []
xref: Reactome:REACT_116000 "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein, Homo sapiens"
is_a: GO:0035250 ! UDP-galactosyltransferase activity
is_a: GO:0048531 ! beta-1,3-galactosyltransferase activity

[Term]
id: GO:0008500
name: obsolete glycine-, glutamate-, thienylcyclohexylpiperidine binding
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it is a conglomeration of three terms.
synonym: "glycine-, glutamate-, thienylcyclohexylpiperidine binding" EXACT []
is_obsolete: true
consider: GO:0016594
consider: GO:0016595
consider: GO:0016596

[Term]
id: GO:0008502
name: melatonin receptor activity
namespace: molecular_function
def: "Combining with melatonin, N-acetyl-5-methoxytryptamine, to initiate a change in cell activity. Melatonin is a neuroendocrine substance that stimulates the aggregation of melanosomes in melanophores, thus lightening the skin." [GOC:ai, ISBN:0198506732]
is_a: GO:0004930 ! G-protein coupled receptor activity

[Term]
id: GO:0008503
name: benzodiazepine receptor activity
namespace: molecular_function
def: "Combining with benzodiazepines, a class of drugs with hypnotic, anxiolytic, anticonvulsive, amnestic and myorelaxant properties, to initiate a change in cell activity." [GOC:jl]
comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'chloride channel activity ; GO:0005254', 'GABA receptor activity ; GO:0016917' and 'inhibitory extracellular ligand-gated ion channel activity ; GO:0005237'.
is_a: GO:0030594 ! neurotransmitter receptor activity

[Term]
id: GO:0008504
name: monoamine transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015201
def: "Enables the transfer of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), from one side of the membrane to the other." [CHEBI:25375, GOC:mah]
xref: Reactome:REACT_101232 "Loading of dopamine into synaptic veiscles, Bos taurus"
xref: Reactome:REACT_102606 "loading of Serotonin in synaptic vesicles, Canis familiaris"
xref: Reactome:REACT_103810 "Reuptake of dopamine from the synaptic cleft into neurons, Danio rerio"
xref: Reactome:REACT_105075 "Reuptake of dopamine from the synaptic cleft into neurons, Canis familiaris"
xref: Reactome:REACT_105240 "Reuptake of dopamine from the synaptic cleft into neurons, Xenopus tropicalis"
xref: Reactome:REACT_108074 "loading of Serotonin in synaptic vesicles, Taeniopygia guttata"
xref: Reactome:REACT_15458 "Reuptake of serotonin from the synapse, Homo sapiens"
xref: Reactome:REACT_15468 "Reuptake of dopamine from the synaptic cleft into neurons, Homo sapiens"
xref: Reactome:REACT_15486 "loading of Serotonin in synaptic vesicles, Homo sapiens"
xref: Reactome:REACT_15524 "Loading of dopamine into synaptic veiscles, Homo sapiens"
xref: Reactome:REACT_20519 "VMAT1/2 can mediate the transport of biogenic amines, Homo sapiens"
xref: Reactome:REACT_30134 "Reuptake of dopamine from the synaptic cleft into neurons, Bos taurus"
xref: Reactome:REACT_30401 "Loading of dopamine into synaptic veiscles, Drosophila melanogaster"
xref: Reactome:REACT_31514 "Reuptake of dopamine from the synaptic cleft into neurons, Rattus norvegicus"
xref: Reactome:REACT_32078 "Loading of dopamine into synaptic veiscles, Danio rerio"
xref: Reactome:REACT_33495 "Reuptake of dopamine from the synaptic cleft into neurons, Sus scrofa"
xref: Reactome:REACT_33697 "Loading of dopamine into synaptic veiscles, Mus musculus"
xref: Reactome:REACT_77207 "Loading of dopamine into synaptic veiscles, Sus scrofa"
xref: Reactome:REACT_79647 "loading of Serotonin in synaptic vesicles, Rattus norvegicus"
xref: Reactome:REACT_79976 "loading of Serotonin in synaptic vesicles, Bos taurus"
xref: Reactome:REACT_80083 "Reuptake of dopamine from the synaptic cleft into neurons, Mus musculus"
xref: Reactome:REACT_80620 "Loading of dopamine into synaptic veiscles, Caenorhabditis elegans"
xref: Reactome:REACT_82031 "loading of Serotonin in synaptic vesicles, Mus musculus"
xref: Reactome:REACT_84650 "loading of Serotonin in synaptic vesicles, Danio rerio"
xref: Reactome:REACT_86065 "loading of Serotonin in synaptic vesicles, Sus scrofa"
xref: Reactome:REACT_87775 "loading of Serotonin in synaptic vesicles, Gallus gallus"
xref: Reactome:REACT_87827 "Loading of dopamine into synaptic veiscles, Taeniopygia guttata"
xref: Reactome:REACT_88820 "Loading of dopamine into synaptic veiscles, Rattus norvegicus"
xref: Reactome:REACT_91757 "loading of Serotonin in synaptic vesicles, Drosophila melanogaster"
xref: Reactome:REACT_94062 "Loading of dopamine into synaptic veiscles, Canis familiaris"
xref: Reactome:REACT_98711 "loading of Serotonin in synaptic vesicles, Caenorhabditis elegans"
xref: Reactome:REACT_99350 "Loading of dopamine into synaptic veiscles, Gallus gallus"
is_a: GO:0022804 ! active transmembrane transporter activity
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity
relationship: part_of GO:0015844 ! monoamine transport

[Term]
id: GO:0008506
name: sucrose:proton symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sucrose(out) + H+(out) = sucrose(in) + H+(in)." [TC:2.A.1.5.3]
synonym: "hydrogen/sucrose transporter activity" BROAD []
synonym: "sucrose:hydrogen symporter activity" EXACT []
is_a: GO:0005351 ! sugar:proton symporter activity
is_a: GO:0008515 ! sucrose transmembrane transporter activity

[Term]
id: GO:0008507
name: sodium:iodide symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: iodide(out) + Na+(out) = iodide(in) + Na+(in)." [TC:2.A.21.5.1]
synonym: "sodium/iodide symporter activity" EXACT []
xref: Reactome:REACT_101270 "Na+/I- cotransport (influx) by the Na+/I- symporter, Sus scrofa"
xref: Reactome:REACT_102904 "Na+/I- cotransport (influx) by the Na+/I- symporter, Canis familiaris"
xref: Reactome:REACT_106845 "Na+/I- cotransport (influx) by the Na+/I- symporter, Xenopus tropicalis"
xref: Reactome:REACT_19340 "Na+/I- cotransport (influx) by the Na+/I- symporter, Homo sapiens"
xref: Reactome:REACT_28309 "Na+/I- cotransport (influx) by the Na+/I- symporter, Bos taurus"
xref: Reactome:REACT_79716 "Na+/I- cotransport (influx) by the Na+/I- symporter, Rattus norvegicus"
xref: Reactome:REACT_79936 "Na+/I- cotransport (influx) by the Na+/I- symporter, Gallus gallus"
xref: Reactome:REACT_82822 "Na+/I- cotransport (influx) by the Na+/I- symporter, Staphylococcus aureus N315"
xref: Reactome:REACT_84388 "Na+/I- cotransport (influx) by the Na+/I- symporter, Mus musculus"
xref: Reactome:REACT_94792 "Na+/I- cotransport (influx) by the Na+/I- symporter, Danio rerio"
is_a: GO:0015373 ! monovalent anion:sodium symporter activity

[Term]
id: GO:0008508
name: bile acid:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(out) + Na+(out) = bile acid(in) + Na+(in)." [TC:2.A.28.-.-]
synonym: "sodium/bile acid symporter activity" EXACT []
xref: Reactome:REACT_10050 "Co-transport (influx) of bile salts and acids and sodium ions by ASBT, Homo sapiens"
xref: Reactome:REACT_101637 "Co-transport (influx) of bile salts and sodium ions by NTCP, Sus scrofa"
xref: Reactome:REACT_102252 "Co-transport (influx) of bile salts and acids and sodium ions by ASBT, Canis familiaris"
xref: Reactome:REACT_102775 "Co-transport (influx) of bile salts and sodium ions by NTCP, Bos taurus"
xref: Reactome:REACT_105390 "SOAT can transport taurolithocholate-3-sulphate, Xenopus tropicalis"
xref: Reactome:REACT_107464 "Co-transport (influx) of bile salts and sodium ions by NTCP, Canis familiaris"
xref: Reactome:REACT_108302 "SOAT can transport taurolithocholate-3-sulphate, Canis familiaris"
xref: Reactome:REACT_110180 "SOAT can transport taurolithocholate-3-sulphate, Bos taurus"
xref: Reactome:REACT_112308 "SOAT can transport taurolithocholate-3-sulphate, Staphylococcus aureus N315"
xref: Reactome:REACT_114282 "Co-transport (influx) of bile salts and acids and sodium ions by ASBT, Xenopus tropicalis"
xref: Reactome:REACT_114427 "Co-transport (influx) of bile salts and sodium ions by NTCP, Danio rerio"
xref: Reactome:REACT_114684 "Co-transport (influx) of bile salts and sodium ions by NTCP, Xenopus tropicalis"
xref: Reactome:REACT_20626 "SOAT can transport taurolithocholate-3-sulphate, Homo sapiens"
xref: Reactome:REACT_33380 "Co-transport (influx) of bile salts and sodium ions by NTCP, Taeniopygia guttata"
xref: Reactome:REACT_40009 "SOAT can transport taurolithocholate-3-sulphate, Mus musculus"
xref: Reactome:REACT_77680 "Co-transport (influx) of bile salts and sodium ions by NTCP, Mus musculus"
xref: Reactome:REACT_80308 "Co-transport (influx) of bile salts and acids and sodium ions by ASBT, Rattus norvegicus"
xref: Reactome:REACT_82767 "Co-transport (influx) of bile salts and acids and sodium ions by ASBT, Mus musculus"
xref: Reactome:REACT_83404 "Co-transport (influx) of bile salts and acids and sodium ions by ASBT, Taeniopygia guttata"
xref: Reactome:REACT_86688 "Co-transport (influx) of bile salts and acids and sodium ions by ASBT, Gallus gallus"
xref: Reactome:REACT_87949 "SOAT can transport taurolithocholate-3-sulphate, Rattus norvegicus"
xref: Reactome:REACT_89587 "Co-transport (influx) of bile salts and acids and sodium ions by ASBT, Bos taurus"
xref: Reactome:REACT_95859 "Co-transport (influx) of bile salts and sodium ions by NTCP, Rattus norvegicus"
xref: Reactome:REACT_99263 "Co-transport (influx) of bile salts and acids and sodium ions by ASBT, Danio rerio"
xref: Reactome:REACT_9958 "Co-transport (influx) of bile salts and sodium ions by NTCP, Homo sapiens"
is_a: GO:0005343 ! organic acid:sodium symporter activity
is_a: GO:0015125 ! bile acid transmembrane transporter activity
is_a: GO:0015296 ! anion:cation symporter activity

[Term]
id: GO:0008509
name: anion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a negatively charged ion from one side of a membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "anion transporter activity" EXACT []
xref: Reactome:REACT_100348 "FA anion flip-flops to the opposite surface, Canis familiaris"
xref: Reactome:REACT_102329 "FA anion flip-flops to the opposite surface, Gallus gallus"
xref: Reactome:REACT_106026 "FA anion flip-flops to the opposite surface, Sus scrofa"
xref: Reactome:REACT_6188 "FA anion flip-flops to the opposite surface, Homo sapiens"
xref: Reactome:REACT_79542 "FA anion flip-flops to the opposite surface, Xenopus tropicalis"
xref: Reactome:REACT_86643 "FA anion flip-flops to the opposite surface, Taeniopygia guttata"
xref: Reactome:REACT_87003 "FA anion flip-flops to the opposite surface, Danio rerio"
xref: Reactome:REACT_88207 "FA anion flip-flops to the opposite surface, Mus musculus"
xref: Reactome:REACT_90836 "FA anion flip-flops to the opposite surface, Oryza sativa"
xref: Reactome:REACT_93989 "FA anion flip-flops to the opposite surface, Bos taurus"
xref: Reactome:REACT_96294 "FA anion flip-flops to the opposite surface, Rattus norvegicus"
xref: Reactome:REACT_99908 "FA anion flip-flops to the opposite surface, Arabidopsis thaliana"
is_a: GO:0015075 ! ion transmembrane transporter activity
relationship: part_of GO:0098656 ! anion transmembrane transport

[Term]
id: GO:0008510
name: sodium:bicarbonate symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + HCO3-(out) = Na+(in) + HCO3-(in)." [TC:2.A.31.2.1]
synonym: "sodium/bicarbonate cotransporter activity" BROAD []
synonym: "sodium:bicarbonate cotransporter activity" BROAD []
xref: Reactome:REACT_101848 "Na+-coupled HCO3- cotransport, Mus musculus"
xref: Reactome:REACT_103062 "Na+-coupled HCO3- cotransport, Gallus gallus"
xref: Reactome:REACT_105262 "Na+-coupled HCO3- cotransport, Drosophila melanogaster"
xref: Reactome:REACT_110033 "Na+-coupled HCO3- cotransport, Taeniopygia guttata"
xref: Reactome:REACT_113404 "Na+-coupled HCO3- cotransport, Dictyostelium discoideum"
xref: Reactome:REACT_19247 "Na+-coupled HCO3- cotransport, Homo sapiens"
xref: Reactome:REACT_30838 "Na+-coupled HCO3- cotransport, Xenopus tropicalis"
xref: Reactome:REACT_86222 "Na+-coupled HCO3- cotransport, Sus scrofa"
xref: Reactome:REACT_87957 "Na+-coupled HCO3- cotransport, Canis familiaris"
xref: Reactome:REACT_89664 "Na+-coupled HCO3- cotransport, Rattus norvegicus"
xref: Reactome:REACT_92116 "Na+-coupled HCO3- cotransport, Bos taurus"
xref: Reactome:REACT_94570 "Na+-coupled HCO3- cotransport, Danio rerio"
xref: Reactome:REACT_98161 "Na+-coupled HCO3- cotransport, Caenorhabditis elegans"
is_a: GO:0015081 ! sodium ion transmembrane transporter activity
is_a: GO:0015106 ! bicarbonate transmembrane transporter activity
is_a: GO:0015296 ! anion:cation symporter activity

[Term]
id: GO:0008511
name: sodium:potassium:chloride symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + K+(out) + Cl-(out) = Na+(in) + K+(in) + Cl-(in)." [TC:2.A.30.1.1]
synonym: "sodium/potassium/chloride symporter activity" EXACT []
xref: Reactome:REACT_102190 "Na+, K+/2Cl- cotransport, Caenorhabditis elegans"
xref: Reactome:REACT_19223 "Na+, K+/2Cl- cotransport, Homo sapiens"
xref: Reactome:REACT_77085 "Na+, K+/2Cl- cotransport, Rattus norvegicus"
xref: Reactome:REACT_77323 "Na+, K+/2Cl- cotransport, Arabidopsis thaliana"
xref: Reactome:REACT_78793 "Na+, K+/2Cl- cotransport, Oryza sativa"
xref: Reactome:REACT_79031 "Na+, K+/2Cl- cotransport, Sus scrofa"
xref: Reactome:REACT_79873 "Na+, K+/2Cl- cotransport, Bos taurus"
xref: Reactome:REACT_80576 "Na+, K+/2Cl- cotransport, Danio rerio"
xref: Reactome:REACT_85482 "Na+, K+/2Cl- cotransport, Xenopus tropicalis"
xref: Reactome:REACT_88821 "Na+, K+/2Cl- cotransport, Mus musculus"
xref: Reactome:REACT_90532 "Na+, K+/2Cl- cotransport, Canis familiaris"
xref: Reactome:REACT_91648 "Na+, K+/2Cl- cotransport, Gallus gallus"
xref: Reactome:REACT_92587 "Na+, K+/2Cl- cotransport, Taeniopygia guttata"
xref: Reactome:REACT_98355 "Na+, K+/2Cl- cotransport, Drosophila melanogaster"
is_a: GO:0015377 ! cation:chloride symporter activity

[Term]
id: GO:0008512
name: sulfate:proton symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in)." [TC:2.A.53.-.-]
synonym: "sulfate/hydrogen symporter activity" EXACT []
synonym: "sulfate:hydrogen symporter activity" EXACT []
synonym: "sulphate:hydrogen symporter activity" EXACT []
is_a: GO:0008271 ! secondary active sulfate transmembrane transporter activity
is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity
is_a: GO:0015295 ! solute:proton symporter activity
is_a: GO:0015296 ! anion:cation symporter activity

[Term]
id: GO:0008513
name: secondary active organic cation transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015354
def: "Catalysis of the transfer of organic cations from one side of the membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction." [GOC:curators]
synonym: "organic cation porter activity" RELATED []
synonym: "polyspecific organic cation transmembrane transporter activity" NARROW []
xref: Reactome:REACT_22304 "OCT4 mediates transport of ergothioneine, Homo sapiens"
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0008514
name: organic anion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008509 ! anion transmembrane transporter activity
relationship: part_of GO:0015711 ! organic anion transport

[Term]
id: GO:0008515
name: sucrose transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0019188
def: "Enables the transfer of sucrose from one side of the membrane to the other. Sucrose is the disaccharide O-beta-D-fructofuranosyl-(2->1)-alpha-D-glucopyranoside, a sweet-tasting, non-reducing sugar isolated industrially from sugar beet or sugar cane." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
subset: gosubset_prok
synonym: "sucrose permease (PTS) activity" EXACT []
synonym: "sucrose permease activity" RELATED []
is_a: GO:0015154 ! disaccharide transmembrane transporter activity
relationship: part_of GO:0015770 ! sucrose transport

[Term]
id: GO:0008516
name: hexose uniporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose(out) = hexose(in)." [TC:2.A.1.1.5]
is_a: GO:0015149 ! hexose transmembrane transporter activity
is_a: GO:0015292 ! uniporter activity

[Term]
id: GO:0008517
name: folic acid transporter activity
namespace: molecular_function
def: "Enables the directed movement of folic acid (pteroylglutamic acid) into, out of or within a cell, or between cells. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines." [GOC:ai]
synonym: "folate transporter activity" EXACT []
synonym: "vitamin B9 transporter activity" EXACT []
synonym: "vitamin M transporter activity" EXACT []
xref: Reactome:REACT_100092 "Extracellular 5-methyltetrahydrofolate import across the plasma membrane, Drosophila melanogaster"
xref: Reactome:REACT_100792 "Cytosolic tetrahydrofolate import across the inner mitochondrial membrane, Bos taurus"
xref: Reactome:REACT_102235 "Cytosolic tetrahydrofolate import across the inner mitochondrial membrane, Saccharomyces cerevisiae"
xref: Reactome:REACT_102653 "Extracellular 5-methyltetrahydrofolate import across the plasma membrane, Gallus gallus"
xref: Reactome:REACT_103611 "Cytosolic tetrahydrofolate import across the inner mitochondrial membrane, Canis familiaris"
xref: Reactome:REACT_103690 "Extracellular 5-methyltetrahydrofolate import across the plasma membrane, Bos taurus"
xref: Reactome:REACT_104433 "Extracellular folate import across the plasma membrane, Taeniopygia guttata"
xref: Reactome:REACT_104504 "Cytosolic tetrahydrofolate import across the inner mitochondrial membrane, Gallus gallus"
xref: Reactome:REACT_105209 "Extracellular 5-methyltetrahydrofolate import across the plasma membrane, Xenopus tropicalis"
xref: Reactome:REACT_106879 "Extracellular folate import across the plasma membrane, Xenopus tropicalis"
xref: Reactome:REACT_107678 "Mitochondrial tetrahydrofolate export across the inner mitochondrial membrane, Caenorhabditis elegans"
xref: Reactome:REACT_107760 "Extracellular 5-methyltetrahydrofolate import across the plasma membrane, Taeniopygia guttata"
xref: Reactome:REACT_108108 "Cytosolic folate export across the plasma membrane, Canis familiaris"
xref: Reactome:REACT_109612 "Extracellular folate import across the plasma membrane, Mus musculus"
xref: Reactome:REACT_109974 "Cytosolic tetrahydrofolate import across the inner mitochondrial membrane, Mus musculus"
xref: Reactome:REACT_110246 "Cytosolic folate export across the plasma membrane, Taeniopygia guttata"
xref: Reactome:REACT_110784 "Cytosolic folate export across the plasma membrane, Mus musculus"
xref: Reactome:REACT_110795 "Cytosolic folate export across the plasma membrane, Xenopus tropicalis"
xref: Reactome:REACT_11104 "Cytosolic folate export across the plasma membrane, Homo sapiens"
xref: Reactome:REACT_11143 "Cytosolic tetrahydrofolate import across the inner mitochondrial membrane, Homo sapiens"
xref: Reactome:REACT_11162 "Extracellular 5-methyltetrahydrofolate import across the plasma membrane, Homo sapiens"
xref: Reactome:REACT_11190 "Extracellular folate import across the plasma membrane, Homo sapiens"
xref: Reactome:REACT_11219 "Mitochondrial tetrahydrofolate export across the inner mitochondrial membrane, Homo sapiens"
xref: Reactome:REACT_28049 "Mitochondrial tetrahydrofolate export across the inner mitochondrial membrane, Oryza sativa"
xref: Reactome:REACT_28889 "Cytosolic folate export across the plasma membrane, Bos taurus"
xref: Reactome:REACT_29114 "Extracellular folate import across the plasma membrane, Canis familiaris"
xref: Reactome:REACT_29378 "Cytosolic tetrahydrofolate import across the inner mitochondrial membrane, Caenorhabditis elegans"
xref: Reactome:REACT_29626 "Extracellular 5-methyltetrahydrofolate import across the plasma membrane, Rattus norvegicus"
xref: Reactome:REACT_30305 "Mitochondrial tetrahydrofolate export across the inner mitochondrial membrane, Canis familiaris"
xref: Reactome:REACT_30524 "Mitochondrial tetrahydrofolate export across the inner mitochondrial membrane, Rattus norvegicus"
xref: Reactome:REACT_30963 "Extracellular folate import across the plasma membrane, Bos taurus"
xref: Reactome:REACT_31808 "Cytosolic tetrahydrofolate import across the inner mitochondrial membrane, Sus scrofa"
xref: Reactome:REACT_31906 "Extracellular 5-methyltetrahydrofolate import across the plasma membrane, Caenorhabditis elegans"
xref: Reactome:REACT_32349 "Cytosolic tetrahydrofolate import across the inner mitochondrial membrane, Drosophila melanogaster"
xref: Reactome:REACT_32790 "Mitochondrial tetrahydrofolate export across the inner mitochondrial membrane, Mus musculus"
xref: Reactome:REACT_33252 "Extracellular 5-methyltetrahydrofolate import across the plasma membrane, Mus musculus"
xref: Reactome:REACT_33312 "Cytosolic folate export across the plasma membrane, Danio rerio"
xref: Reactome:REACT_33623 "Mitochondrial tetrahydrofolate export across the inner mitochondrial membrane, Danio rerio"
xref: Reactome:REACT_77168 "Extracellular 5-methyltetrahydrofolate import across the plasma membrane, Canis familiaris"
xref: Reactome:REACT_79209 "Mitochondrial tetrahydrofolate export across the inner mitochondrial membrane, Drosophila melanogaster"
xref: Reactome:REACT_80608 "Extracellular 5-methyltetrahydrofolate import across the plasma membrane, Danio rerio"
xref: Reactome:REACT_81227 "Cytosolic tetrahydrofolate import across the inner mitochondrial membrane, Rattus norvegicus"
xref: Reactome:REACT_81287 "Cytosolic tetrahydrofolate import across the inner mitochondrial membrane, Danio rerio"
xref: Reactome:REACT_83039 "Cytosolic tetrahydrofolate import across the inner mitochondrial membrane, Taeniopygia guttata"
xref: Reactome:REACT_83176 "Extracellular folate import across the plasma membrane, Gallus gallus"
xref: Reactome:REACT_83346 "Cytosolic tetrahydrofolate import across the inner mitochondrial membrane, Oryza sativa"
xref: Reactome:REACT_83401 "Cytosolic tetrahydrofolate import across the inner mitochondrial membrane, Arabidopsis thaliana"
xref: Reactome:REACT_84236 "Cytosolic folate export across the plasma membrane, Gallus gallus"
xref: Reactome:REACT_84854 "Mitochondrial tetrahydrofolate export across the inner mitochondrial membrane, Saccharomyces cerevisiae"
xref: Reactome:REACT_85392 "Extracellular 5-methyltetrahydrofolate import across the plasma membrane, Dictyostelium discoideum"
xref: Reactome:REACT_86460 "Mitochondrial tetrahydrofolate export across the inner mitochondrial membrane, Dictyostelium discoideum"
xref: Reactome:REACT_87620 "Mitochondrial tetrahydrofolate export across the inner mitochondrial membrane, Xenopus tropicalis"
xref: Reactome:REACT_88323 "Cytosolic folate export across the plasma membrane, Rattus norvegicus"
xref: Reactome:REACT_88962 "Mitochondrial tetrahydrofolate export across the inner mitochondrial membrane, Schizosaccharomyces pombe"
xref: Reactome:REACT_89284 "Cytosolic tetrahydrofolate import across the inner mitochondrial membrane, Schizosaccharomyces pombe"
xref: Reactome:REACT_90158 "Cytosolic tetrahydrofolate import across the inner mitochondrial membrane, Xenopus tropicalis"
xref: Reactome:REACT_90549 "Extracellular folate import across the plasma membrane, Danio rerio"
xref: Reactome:REACT_90989 "Mitochondrial tetrahydrofolate export across the inner mitochondrial membrane, Sus scrofa"
xref: Reactome:REACT_91248 "Mitochondrial tetrahydrofolate export across the inner mitochondrial membrane, Arabidopsis thaliana"
xref: Reactome:REACT_92306 "Extracellular folate import across the plasma membrane, Rattus norvegicus"
xref: Reactome:REACT_92328 "Mitochondrial tetrahydrofolate export across the inner mitochondrial membrane, Gallus gallus"
xref: Reactome:REACT_94465 "Mitochondrial tetrahydrofolate export across the inner mitochondrial membrane, Taeniopygia guttata"
xref: Reactome:REACT_96149 "Mitochondrial tetrahydrofolate export across the inner mitochondrial membrane, Bos taurus"
xref: Reactome:REACT_98444 "Cytosolic tetrahydrofolate import across the inner mitochondrial membrane, Dictyostelium discoideum"
is_a: GO:0051183 ! vitamin transporter activity
is_a: GO:0051184 ! cofactor transporter activity
relationship: part_of GO:0015884 ! folic acid transport

[Term]
id: GO:0008518
name: reduced folate carrier activity
namespace: molecular_function
def: "Catalysis of the transfer of reduced folate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport]
synonym: "reduced folate transporter" BROAD []
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0008519
name: ammonium transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0051739
def: "Enables the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "ammonia transmembrane transporter activity" EXACT []
xref: Reactome:REACT_20505 "RhCG mediates ammonium efflux out of kidney collecting duct cells, Homo sapiens"
xref: Reactome:REACT_20532 "RhAG mediates ammounium export from red blood cells, Homo sapiens"
xref: Reactome:REACT_20571 "RhBG mediates ammonium influx into kidney collecting duct cells, Homo sapiens"
xref: Reactome:REACT_20654 "RhBG mediates ammonium effflux out of kidney collecting duct cells, Homo sapiens"
xref: Reactome:REACT_20677 "RhCG mediates ammonium influx into kidney collecting duct cells, Homo sapiens"
xref: RHEA:28750
is_a: GO:0015077 ! monovalent inorganic cation transmembrane transporter activity
relationship: part_of GO:0072488 ! ammonium transmembrane transport

[Term]
id: GO:0008520
name: L-ascorbate:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ascorbate(out) + Na+(out) = ascorbate(in) + Na+(in)." [TC:2.A.40.6.1]
synonym: "sodium-dependent L-ascorbic acid transporter" RELATED []
is_a: GO:0005343 ! organic acid:sodium symporter activity
is_a: GO:0015145 ! monosaccharide transmembrane transporter activity
is_a: GO:0015229 ! L-ascorbic acid transporter activity
is_a: GO:0015296 ! anion:cation symporter activity
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity
is_a: GO:0090482 ! vitamin transmembrane transporter activity

[Term]
id: GO:0008521
name: acetyl-CoA transporter activity
namespace: molecular_function
def: "Enables the directed movement of acetyl-CoA into, out of or within a cell, or between cells. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis." [GOC:ai]
xref: Reactome:REACT_22226 "AT1 transports acetyl-CoA into the Golgi lumen, Homo sapiens"
is_a: GO:0051185 ! coenzyme transporter activity
relationship: part_of GO:0015876 ! acetyl-CoA transport

[Term]
id: GO:0008523
name: sodium-dependent multivitamin transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: multivitamin(out) + Na+(out) = multivitamin(in) + Na+(in). Multivitamins include pantothenate, biotin and lipoate." [TC:2.A.21.5.2]
xref: Reactome:REACT_102367 "Na+-dependent multivitamin transporter, Sus scrofa"
xref: Reactome:REACT_106158 "Biotin transport across the plasma membrane, Danio rerio"
xref: Reactome:REACT_108388 "Pantothenate transport across the plasma membrane, Taeniopygia guttata"
xref: Reactome:REACT_109116 "Biotin transport across the plasma membrane, Xenopus tropicalis"
xref: Reactome:REACT_11072 "Pantothenate transport across the plasma membrane, Homo sapiens"
xref: Reactome:REACT_11142 "Biotin transport across the plasma membrane, Homo sapiens"
xref: Reactome:REACT_22320 "Na+-dependent multivitamin transporter, Homo sapiens"
xref: Reactome:REACT_77425 "Na+-dependent multivitamin transporter, Staphylococcus aureus N315"
xref: Reactome:REACT_77656 "Biotin transport across the plasma membrane, Rattus norvegicus"
xref: Reactome:REACT_77771 "Na+-dependent multivitamin transporter, Taeniopygia guttata"
xref: Reactome:REACT_78025 "Pantothenate transport across the plasma membrane, Sus scrofa"
xref: Reactome:REACT_78135 "Na+-dependent multivitamin transporter, Mus musculus"
xref: Reactome:REACT_78388 "Na+-dependent multivitamin transporter, Xenopus tropicalis"
xref: Reactome:REACT_78918 "Pantothenate transport across the plasma membrane, Danio rerio"
xref: Reactome:REACT_79324 "Pantothenate transport across the plasma membrane, Staphylococcus aureus N315"
xref: Reactome:REACT_80209 "Pantothenate transport across the plasma membrane, Mus musculus"
xref: Reactome:REACT_80635 "Biotin transport across the plasma membrane, Staphylococcus aureus N315"
xref: Reactome:REACT_83124 "Biotin transport across the plasma membrane, Sus scrofa"
xref: Reactome:REACT_83591 "Na+-dependent multivitamin transporter, Rattus norvegicus"
xref: Reactome:REACT_84024 "Pantothenate transport across the plasma membrane, Bos taurus"
xref: Reactome:REACT_84432 "Biotin transport across the plasma membrane, Bos taurus"
xref: Reactome:REACT_84923 "Biotin transport across the plasma membrane, Taeniopygia guttata"
xref: Reactome:REACT_85143 "Pantothenate transport across the plasma membrane, Xenopus tropicalis"
xref: Reactome:REACT_87293 "Na+-dependent multivitamin transporter, Canis familiaris"
xref: Reactome:REACT_87999 "Biotin transport across the plasma membrane, Canis familiaris"
xref: Reactome:REACT_88097 "Pantothenate transport across the plasma membrane, Canis familiaris"
xref: Reactome:REACT_90168 "Pantothenate transport across the plasma membrane, Rattus norvegicus"
xref: Reactome:REACT_91073 "Biotin transport across the plasma membrane, Mus musculus"
xref: Reactome:REACT_96073 "Na+-dependent multivitamin transporter, Bos taurus"
xref: Reactome:REACT_97833 "Na+-dependent multivitamin transporter, Danio rerio"
is_a: GO:0015370 ! solute:sodium symporter activity
is_a: GO:0090482 ! vitamin transmembrane transporter activity

[Term]
id: GO:0008524
name: glucose 6-phosphate:phosphate antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose 6-phosphate(out) + phosphate(in) = glucose 6-phosphate(in) + phosphate(out)." [TC:2.A.1.-.-]
is_a: GO:0015315 ! organophosphate:inorganic phosphate antiporter activity
relationship: part_of GO:0005355 ! glucose transmembrane transporter activity

[Term]
id: GO:0008525
name: phosphatidylcholine transporter activity
namespace: molecular_function
def: "Enables the directed movement of phosphatidylcholine into, out of or within a cell, or between cells. Phosphatidylcholine refers to a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:ai, ISBN:0198506732]
synonym: "phosphatidylcholine transmembrane transporter activity" NARROW [GOC:bf, GOC:vw]
is_a: GO:0005548 ! phospholipid transporter activity

[Term]
id: GO:0008526
name: phosphatidylinositol transporter activity
namespace: molecular_function
def: "Enables the directed movement of phosphatidylinositol into, out of or within a cell, or between cells. Phosphatidylinositol refers to any glycophospholipids with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [GOC:ai, ISBN:0198506732]
synonym: "phosphatidylinositol transfer" EXACT []
is_a: GO:0005548 ! phospholipid transporter activity

[Term]
id: GO:0008527
name: taste receptor activity
namespace: molecular_function
def: "Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste." [GOC:dph]
synonym: "gustatory receptor" EXACT []
is_a: GO:0004930 ! G-protein coupled receptor activity
relationship: part_of GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste

[Term]
id: GO:0008528
name: G-protein coupled peptide receptor activity
namespace: molecular_function
def: "Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:dph, GOC:tb]
synonym: "G protein coupled peptide receptor activity" EXACT []
synonym: "G-protein-coupled peptide receptor activity" EXACT []
synonym: "peptide receptor activity, G protein coupled" EXACT []
synonym: "peptide receptor activity, G-protein coupled" EXACT [GOC:bf]
is_a: GO:0001653 ! peptide receptor activity
is_a: GO:0004930 ! G-protein coupled receptor activity

[Term]
id: GO:0008529
name: obsolete endogenous peptide receptor activity
namespace: molecular_function
def: "OBSOLETE. Combining with an intracellular peptide to initiate a change in cell activity." [GOC:ai]
comment: This term was made obsolete because it contains both component and function information.
synonym: "endogenous peptide receptor activity" EXACT []
is_obsolete: true
consider: GO:0001653
consider: GO:0005622

[Term]
id: GO:0008530
name: obsolete exogenous peptide receptor activity
namespace: molecular_function
def: "OBSOLETE. Combining with an extracellular peptide to initiate a change in cell activity." [GOC:ai]
comment: This term was made obsolete because it contains both component and function information.
synonym: "exogenous peptide receptor activity" EXACT []
is_obsolete: true
consider: GO:0001653
consider: GO:0005576

[Term]
id: GO:0008531
name: riboflavin kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + riboflavin = ADP + FMN + 2 H(+)." [EC:2.7.1.26, RHEA:14360]
subset: gosubset_prok
synonym: "ATP:riboflavin 5'-phosphotransferase activity" EXACT [EC:2.7.1.26]
synonym: "FK" RELATED [EC:2.7.1.26]
synonym: "flavokinase activity" EXACT [EC:2.7.1.26]
synonym: "riboflavin kinase (phosphorylating)" EXACT [EC:2.7.1.26]
synonym: "riboflavine kinase activity" EXACT [EC:2.7.1.26]
xref: EC:2.7.1.26
xref: KEGG:R00549
xref: MetaCyc:RIBOFLAVINKIN-RXN
xref: Reactome:REACT_100594 "Riboflavin is phosphorylated to FMN, Sus scrofa"
xref: Reactome:REACT_106998 "Riboflavin is phosphorylated to FMN, Gallus gallus"
xref: Reactome:REACT_108291 "Riboflavin is phosphorylated to FMN, Saccharomyces cerevisiae"
xref: Reactome:REACT_11232 "Riboflavin is phosphorylated to FMN, Homo sapiens"
xref: Reactome:REACT_114647 "Riboflavin is phosphorylated to FMN, Canis familiaris"
xref: Reactome:REACT_33404 "Riboflavin is phosphorylated to FMN, Caenorhabditis elegans"
xref: Reactome:REACT_34687 "Riboflavin is phosphorylated to FMN, Danio rerio"
xref: Reactome:REACT_80178 "Riboflavin is phosphorylated to FMN, Schizosaccharomyces pombe"
xref: Reactome:REACT_83152 "Riboflavin is phosphorylated to FMN, Taeniopygia guttata"
xref: Reactome:REACT_84159 "Riboflavin is phosphorylated to FMN, Drosophila melanogaster"
xref: Reactome:REACT_84393 "Riboflavin is phosphorylated to FMN, Xenopus tropicalis"
xref: Reactome:REACT_89808 "Riboflavin is phosphorylated to FMN, Mus musculus"
xref: Reactome:REACT_95970 "Riboflavin is phosphorylated to FMN, Bos taurus"
xref: Reactome:REACT_99014 "Riboflavin is phosphorylated to FMN, Plasmodium falciparum"
xref: RHEA:14360
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0008532
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R." [EC:2.4.1.149]
synonym: "galbeta1->4GlcNAc-R beta1->3 N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.149]
synonym: "GnTE activity" EXACT [EC:2.4.1.149]
synonym: "N-acetyllactosamine beta(1,3)N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.149]
synonym: "poly-N-acetyllactosamine extension enzyme activity" BROAD [EC:2.4.1.149]
synonym: "UDP-GlcNAc:Galbeta-(1,4)-GlcNAcbeta-r-beta-(1,3)-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.149]
synonym: "UDP-GlcNAc:Galbeta-1,4-GlcNAcbeta-beta-1,3-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.149]
synonym: "UDP-GlcNAc:GalR, beta-D-3-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.149]
synonym: "UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-D-glucosamine beta-1,3-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.149]
synonym: "uridine diphosphoacetylglucosamine-acetyllactosaminide beta-1,3-acetylglucosaminyltransferase" BROAD [EC:2.4.1.149]
synonym: "uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->3-acetylglucosaminyltransferase" BROAD [EC:2.4.1.149]
xref: EC:2.4.1.149
xref: MetaCyc:2.4.1.149-RXN
xref: RHEA:14392
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0008533
name: obsolete astacin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds in substrates containing five or more amino acids, preferentially with Ala in P1', and Pro in P2'." [EC:3.4.24.21]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "astacin activity" EXACT []
synonym: "Astacus proteinase activity" EXACT [EC:3.4.24.21]
synonym: "astacus proteinase activity" NARROW [EC:3.4.24.21]
synonym: "crayfish small-molecule proteinase activity" NARROW [EC:3.4.24.21]
xref: EC:3.4.24.21
xref: MetaCyc:3.4.24.21-RXN
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0008534
name: oxidized purine nucleobase lesion DNA N-glycosylase activity
namespace: molecular_function
alt_id: GO:0003907
def: "Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site." [GOC:elh, PMID:11554296]
comment: Consider also annotating to the molecular function term 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906'.
subset: gosubset_prok
synonym: "2,6-diamino-4-hydroxy-5(N-methyl)formamidopyrimidine-DNA glycosylase activity" EXACT [EC:3.2.2.23]
synonym: "2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase activity" EXACT [EC:3.2.2.23]
synonym: "8-oxoguanine DNA glycosylase activity" BROAD []
synonym: "bifunctional DNA glycosylase activity" BROAD []
synonym: "deoxyribonucleate glycosidase activity" EXACT [EC:3.2.2.23]
synonym: "DNA glycohydrolase [2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimide releasing]" RELATED [EC:3.2.2.23]
synonym: "DNA glycosylase/AP-lyase activity" BROAD []
synonym: "DNA glycosylase/beta-lyase activity" BROAD []
synonym: "DNA-formamidopyrimidine glycosylase activity" EXACT []
synonym: "Fapy-DNA glycosylase activity" EXACT [EC:3.2.2.23]
synonym: "formamidopyrimidine-DNA glycosylase activity" EXACT []
synonym: "Fpg protein" RELATED [EC:3.2.2.23]
synonym: "oxidized purine base lesion DNA N-glycosylase activity" EXACT [GOC:curators]
synonym: "purine-specific oxidized base lesion DNA N-glycosylase activity" RELATED []
xref: EC:3.2.2.23
xref: MetaCyc:3.2.2.23-RXN
xref: Reactome:REACT_1013 "Cleavage of formamidopyrimidine by hOGG1 glycosylase, Homo sapiens"
xref: Reactome:REACT_105365 "Cleavage of 8-oxo guanine by hOGG1 glycosylase, Dictyostelium discoideum"
xref: Reactome:REACT_106495 "Cleavage of formamidopyrimidine by hOGG1 glycosylase, Danio rerio"
xref: Reactome:REACT_106926 "Cleavage of formamidopyrimidine by hOGG1 glycosylase, Mus musculus"
xref: Reactome:REACT_1737 "Cleavage of 8-oxo guanine by hOGG1 glycosylase, Homo sapiens"
xref: Reactome:REACT_28313 "Cleavage of 8-oxo guanine by hOGG1 glycosylase, Rattus norvegicus"
xref: Reactome:REACT_28730 "Cleavage of 8-oxo guanine by hOGG1 glycosylase, Saccharomyces cerevisiae"
xref: Reactome:REACT_28897 "Cleavage of formamidopyrimidine by hOGG1 glycosylase, Gallus gallus"
xref: Reactome:REACT_30986 "Cleavage of 8-oxo guanine by hOGG1 glycosylase, Gallus gallus"
xref: Reactome:REACT_34247 "Cleavage of formamidopyrimidine by hOGG1 glycosylase, Arabidopsis thaliana"
xref: Reactome:REACT_78313 "Cleavage of formamidopyrimidine by hOGG1 glycosylase, Dictyostelium discoideum"
xref: Reactome:REACT_78507 "Cleavage of formamidopyrimidine by hOGG1 glycosylase, Drosophila melanogaster"
xref: Reactome:REACT_80636 "Cleavage of 8-oxo guanine by hOGG1 glycosylase, Arabidopsis thaliana"
xref: Reactome:REACT_81413 "Cleavage of 8-oxo guanine by hOGG1 glycosylase, Plasmodium falciparum"
xref: Reactome:REACT_83644 "Cleavage of 8-oxo guanine by hOGG1 glycosylase, Mus musculus"
xref: Reactome:REACT_83822 "Cleavage of 8-oxo guanine by hOGG1 glycosylase, Sus scrofa"
xref: Reactome:REACT_85747 "Cleavage of 8-oxo guanine by hOGG1 glycosylase, Drosophila melanogaster"
xref: Reactome:REACT_88552 "Cleavage of formamidopyrimidine by hOGG1 glycosylase, Saccharomyces cerevisiae"
xref: Reactome:REACT_90260 "Cleavage of 8-oxo guanine by hOGG1 glycosylase, Bos taurus"
xref: Reactome:REACT_91493 "Cleavage of formamidopyrimidine by hOGG1 glycosylase, Sus scrofa"
xref: Reactome:REACT_92331 "Cleavage of formamidopyrimidine by hOGG1 glycosylase, Rattus norvegicus"
xref: Reactome:REACT_93857 "Cleavage of formamidopyrimidine by hOGG1 glycosylase, Canis familiaris"
xref: Reactome:REACT_95950 "Cleavage of 8-oxo guanine by hOGG1 glycosylase, Danio rerio"
xref: Reactome:REACT_97968 "Cleavage of formamidopyrimidine by hOGG1 glycosylase, Plasmodium falciparum"
xref: Reactome:REACT_98820 "Cleavage of 8-oxo guanine by hOGG1 glycosylase, Canis familiaris"
xref: Reactome:REACT_98984 "Cleavage of formamidopyrimidine by hOGG1 glycosylase, Bos taurus"
is_a: GO:0000702 ! oxidized base lesion DNA N-glycosylase activity
is_a: GO:0003906 ! DNA-(apurinic or apyrimidinic site) lyase activity

[Term]
id: GO:0008535
name: respiratory chain complex IV assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase), the terminal member of the respiratory chain of the mitochondrion and some aerobic bacteria. Cytochrome c oxidases are multi-subunit enzymes containing from 13 subunits in the mammalian mitochondrial form to 3-4 subunits in the bacterial forms." [GOC:jl, http://www.med.wright.edu/bmb/lp/lplab.htm]
subset: gosubset_prok
synonym: "cytochrome c oxidase biogenesis" BROAD []
synonym: "cytochrome c oxidase complex assembly" EXACT []
is_a: GO:0017004 ! cytochrome complex assembly

[Term]
id: GO:0008536
name: Ran GTPase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with Ran, a conserved Ras-like GTP-binding protein, implicated in nucleocytoplasmic transport, cell cycle progression, spindle assembly, nuclear organization and nuclear envelope (NE) assembly." [GOC:rn, PMID:12787777, PMID:14726649]
synonym: "Ran protein binding" EXACT []
synonym: "Ran-binding protein" RELATED []
is_a: GO:0017016 ! Ras GTPase binding

[Term]
id: GO:0008537
name: proteasome activator complex
namespace: cellular_component
def: "A multisubunit complex that activates the hydrolysis of small nonubiquitinated peptides by binding to the proteasome core complex." [GOC:rb]
synonym: "PA28" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0022624 ! proteasome accessory complex

[Term]
id: GO:0008538
name: obsolete proteasome activator activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the activation of the proteasome, a large multisubunit complex which performs regulated ubiquitin-dependent cytosolic and nuclear proteolysis." [GOC:rn, PMID:10428771]
comment: The term was made obsolete because 'proteasome' is not a valid molecular function term.
synonym: "PA28" NARROW []
synonym: "proteasome activator activity" EXACT []
is_obsolete: true
consider: GO:0061133
consider: GO:0061136

[Term]
id: GO:0008539
name: obsolete proteasome inhibitor activity
namespace: molecular_function
def: "OBSOLETE. Stops, prevents or reduces the activity of the proteasome complex. The proteasome complex performs regulated ubiquitin-dependent cytosolic and nuclear proteolysis." [GOC:mah]
comment: The term was made obsolete because 'proteasome' is not a valid molecular function term.
synonym: "PI-31" NARROW []
synonym: "proteasome inhibitor activity" EXACT []
is_obsolete: true
consider: GO:0004866
consider: GO:0061136

[Term]
id: GO:0008540
name: proteasome regulatory particle, base subcomplex
namespace: cellular_component
def: "The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex." [GOC:mtg_sensu, GOC:rb]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0005838 ! proteasome regulatory particle

[Term]
id: GO:0008541
name: proteasome regulatory particle, lid subcomplex
namespace: cellular_component
def: "The subcomplex of the proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex." [GOC:rb]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0005838 ! proteasome regulatory particle

[Term]
id: GO:0008542
name: visual learning
namespace: biological_process
def: "Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue." [GOC:jid, ISBN:0582227089]
synonym: "spatial learning" RELATED []
is_a: GO:0007632 ! visual behavior
is_a: GO:0008306 ! associative learning

[Term]
id: GO:0008543
name: fibroblast growth factor receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands." [GOC:ceb]
synonym: "FGF receptor signaling pathway" EXACT []
synonym: "FGF receptor signalling pathway" EXACT []
synonym: "FGFR signaling pathway" EXACT []
synonym: "fibroblast growth factor receptor signalling pathway" EXACT []
xref: Reactome:REACT_100065 "FGFR1c ligand binding and activation, Mus musculus"
xref: Reactome:REACT_100193 "FGFR3c ligand binding and activation, Gallus gallus"
xref: Reactome:REACT_100425 "FGFR3c ligand binding and activation, Canis familiaris"
xref: Reactome:REACT_100634 "FGFR2c ligand binding and activation, Drosophila melanogaster"
xref: Reactome:REACT_100821 "FGFR1c and Klotho ligand binding and activation, Xenopus tropicalis"
xref: Reactome:REACT_101067 "Signaling by FGFR, Xenopus tropicalis"
xref: Reactome:REACT_101256 "FGFR1 ligand binding and activation, Sus scrofa"
xref: Reactome:REACT_101261 "FGFR3b ligand binding and activation, Drosophila melanogaster"
xref: Reactome:REACT_101330 "FGFR1b ligand binding and activation, Danio rerio"
xref: Reactome:REACT_101676 "Signaling by FGFR, Gallus gallus"
xref: Reactome:REACT_101991 "FGFR3c ligand binding and activation, Danio rerio"
xref: Reactome:REACT_102813 "Signaling by FGFR, Sus scrofa"
xref: Reactome:REACT_102900 "FGFR1 ligand binding and activation, Rattus norvegicus"
xref: Reactome:REACT_102940 "FGFR1 ligand binding and activation, Xenopus tropicalis"
xref: Reactome:REACT_102983 "FGFR3c ligand binding and activation, Taeniopygia guttata"
xref: Reactome:REACT_103309 "FGFR1c ligand binding and activation, Xenopus tropicalis"
xref: Reactome:REACT_103577 "Signaling by FGFR, Caenorhabditis elegans"
xref: Reactome:REACT_104466 "FGFR3c ligand binding and activation, Bos taurus"
xref: Reactome:REACT_105552 "Signaling by FGFR, Mus musculus"
xref: Reactome:REACT_105801 "FGFR2 ligand binding and activation, Gallus gallus"
xref: Reactome:REACT_105808 "FGFR2c ligand binding and activation, Danio rerio"
xref: Reactome:REACT_106282 "FGFR2 ligand binding and activation, Taeniopygia guttata"
xref: Reactome:REACT_106586 "FGFR1c and Klotho ligand binding and activation, Canis familiaris"
xref: Reactome:REACT_107516 "FGFR3 ligand binding and activation, Canis familiaris"
xref: Reactome:REACT_107792 "FGFR2b ligand binding and activation, Bos taurus"
xref: Reactome:REACT_108048 "FGFR3 ligand binding and activation, Bos taurus"
xref: Reactome:REACT_108057 "FGFR3b ligand binding and activation, Bos taurus"
xref: Reactome:REACT_108384 "FGFR1c ligand binding and activation, Drosophila melanogaster"
xref: Reactome:REACT_108645 "Signaling by FGFR, Arabidopsis thaliana"
xref: Reactome:REACT_109427 "FGFR1 ligand binding and activation, Canis familiaris"
xref: Reactome:REACT_109441 "FGFR4 ligand binding and activation, Bos taurus"
xref: Reactome:REACT_109874 "FGFR2 ligand binding and activation, Danio rerio"
xref: Reactome:REACT_110057 "Signaling by FGFR, Rattus norvegicus"
xref: Reactome:REACT_110157 "FGFR2b ligand binding and activation, Rattus norvegicus"
xref: Reactome:REACT_110334 "FGFR3 ligand binding and activation, Xenopus tropicalis"
xref: Reactome:REACT_110540 "FGFR1c and Klotho ligand binding and activation, Sus scrofa"
xref: Reactome:REACT_110592 "FGFR ligand binding and activation, Taeniopygia guttata"
xref: Reactome:REACT_110686 "FGFR3b ligand binding and activation, Canis familiaris"
xref: Reactome:REACT_110991 "FGFR2 ligand binding and activation, Canis familiaris"
xref: Reactome:REACT_112148 "FGFR1b ligand binding and activation, Drosophila melanogaster"
xref: Reactome:REACT_112458 "Signaling by FGFR, Mycobacterium tuberculosis"
xref: Reactome:REACT_112770 "FGFR2 ligand binding and activation, Caenorhabditis elegans"
xref: Reactome:REACT_113040 "FGFR1c ligand binding and activation, Caenorhabditis elegans"
xref: Reactome:REACT_113367 "Signaling by FGFR, Plasmodium falciparum"
xref: Reactome:REACT_113498 "FGFR3b ligand binding and activation, Caenorhabditis elegans"
xref: Reactome:REACT_113682 "FGFR3c ligand binding and activation, Caenorhabditis elegans"
xref: Reactome:REACT_114115 "FGFR3 ligand binding and activation, Caenorhabditis elegans"
xref: Reactome:REACT_114162 "FGFR2b ligand binding and activation, Caenorhabditis elegans"
xref: Reactome:REACT_114328 "Signaling by FGFR, Saccharomyces cerevisiae"
xref: Reactome:REACT_114758 "FGFR2c ligand binding and activation, Caenorhabditis elegans"
xref: Reactome:REACT_114804 "FGFR2b ligand binding and activation, Drosophila melanogaster"
xref: Reactome:REACT_115170 "FGFR1 ligand binding and activation, Caenorhabditis elegans"
xref: Reactome:REACT_115181 "Signaling by FGFR, Schizosaccharomyces pombe"
xref: Reactome:REACT_115307 "FGFR1b ligand binding and activation, Caenorhabditis elegans"
xref: Reactome:REACT_115350 "FGFR4 ligand binding and activation, Caenorhabditis elegans"
xref: Reactome:REACT_115356 "FGFR ligand binding and activation, Caenorhabditis elegans"
xref: Reactome:REACT_29132 "FGFR4 ligand binding and activation, Rattus norvegicus"
xref: Reactome:REACT_29169 "FGFR1b ligand binding and activation, Xenopus tropicalis"
xref: Reactome:REACT_29211 "FGFR1 ligand binding and activation, Drosophila melanogaster"
xref: Reactome:REACT_29608 "FGFR2c ligand binding and activation, Rattus norvegicus"
xref: Reactome:REACT_30012 "FGFR2 ligand binding and activation, Rattus norvegicus"
xref: Reactome:REACT_30171 "FGFR ligand binding and activation, Danio rerio"
xref: Reactome:REACT_31565 "FGFR1c and Klotho ligand binding and activation, Danio rerio"
xref: Reactome:REACT_31885 "FGFR1 ligand binding and activation, Bos taurus"
xref: Reactome:REACT_32561 "FGFR2b ligand binding and activation, Canis familiaris"
xref: Reactome:REACT_33067 "FGFR1b ligand binding and activation, Rattus norvegicus"
xref: Reactome:REACT_33299 "FGFR4 ligand binding and activation, Danio rerio"
xref: Reactome:REACT_33345 "FGFR2b ligand binding and activation, Sus scrofa"
xref: Reactome:REACT_33851 "FGFR2c ligand binding and activation, Bos taurus"
xref: Reactome:REACT_35254 "FGFR3 ligand binding and activation, Gallus gallus"
xref: Reactome:REACT_77367 "FGFR2 ligand binding and activation, Bos taurus"
xref: Reactome:REACT_77757 "FGFR1 ligand binding and activation, Gallus gallus"
xref: Reactome:REACT_77974 "FGFR1b ligand binding and activation, Taeniopygia guttata"
xref: Reactome:REACT_77976 "FGFR3b ligand binding and activation, Taeniopygia guttata"
xref: Reactome:REACT_78827 "FGFR4 ligand binding and activation, Sus scrofa"
xref: Reactome:REACT_80195 "FGFR1c ligand binding and activation, Bos taurus"
xref: Reactome:REACT_80511 "FGFR4 ligand binding and activation, Xenopus tropicalis"
xref: Reactome:REACT_80522 "FGFR1c ligand binding and activation, Gallus gallus"
xref: Reactome:REACT_81030 "FGFR3 ligand binding and activation, Mus musculus"
xref: Reactome:REACT_81325 "FGFR3c ligand binding and activation, Sus scrofa"
xref: Reactome:REACT_81423 "FGFR ligand binding and activation, Sus scrofa"
xref: Reactome:REACT_82006 "FGFR2c ligand binding and activation, Sus scrofa"
xref: Reactome:REACT_82177 "FGFR ligand binding and activation, Rattus norvegicus"
xref: Reactome:REACT_82322 "FGFR2 ligand binding and activation, Drosophila melanogaster"
xref: Reactome:REACT_82471 "FGFR3 ligand binding and activation, Sus scrofa"
xref: Reactome:REACT_82575 "FGFR ligand binding and activation, Drosophila melanogaster"
xref: Reactome:REACT_83368 "FGFR2c ligand binding and activation, Gallus gallus"
xref: Reactome:REACT_83542 "FGFR1 ligand binding and activation, Mus musculus"
xref: Reactome:REACT_83620 "FGFR1c and Klotho ligand binding and activation, Bos taurus"
xref: Reactome:REACT_83621 "FGFR4 ligand binding and activation, Drosophila melanogaster"
xref: Reactome:REACT_83736 "FGFR2b ligand binding and activation, Danio rerio"
xref: Reactome:REACT_83962 "FGFR1c and Klotho ligand binding and activation, Gallus gallus"
xref: Reactome:REACT_84212 "FGFR2 ligand binding and activation, Mus musculus"
xref: Reactome:REACT_84313 "Signaling by FGFR, Drosophila melanogaster"
xref: Reactome:REACT_84439 "FGFR ligand binding and activation, Xenopus tropicalis"
xref: Reactome:REACT_84550 "FGFR1c ligand binding and activation, Rattus norvegicus"
xref: Reactome:REACT_84563 "FGFR3b ligand binding and activation, Mus musculus"
xref: Reactome:REACT_84728 "FGFR3b ligand binding and activation, Xenopus tropicalis"
xref: Reactome:REACT_84755 "FGFR ligand binding and activation, Canis familiaris"
xref: Reactome:REACT_85014 "FGFR1 ligand binding and activation, Taeniopygia guttata"
xref: Reactome:REACT_85212 "Signaling by FGFR, Bos taurus"
xref: Reactome:REACT_85655 "FGFR1b ligand binding and activation, Mus musculus"
xref: Reactome:REACT_86158 "FGFR3b ligand binding and activation, Sus scrofa"
xref: Reactome:REACT_86258 "FGFR4 ligand binding and activation, Canis familiaris"
xref: Reactome:REACT_86405 "FGFR3 ligand binding and activation, Rattus norvegicus"
xref: Reactome:REACT_86768 "FGFR2c ligand binding and activation, Canis familiaris"
xref: Reactome:REACT_86829 "FGFR2 ligand binding and activation, Xenopus tropicalis"
xref: Reactome:REACT_87339 "FGFR1c ligand binding and activation, Sus scrofa"
xref: Reactome:REACT_87721 "FGFR3b ligand binding and activation, Gallus gallus"
xref: Reactome:REACT_87759 "FGFR2c ligand binding and activation, Taeniopygia guttata"
xref: Reactome:REACT_87866 "FGFR3b ligand binding and activation, Danio rerio"
xref: Reactome:REACT_87927 "FGFR3c ligand binding and activation, Mus musculus"
xref: Reactome:REACT_88012 "FGFR2b ligand binding and activation, Gallus gallus"
xref: Reactome:REACT_88057 "FGFR2b ligand binding and activation, Xenopus tropicalis"
xref: Reactome:REACT_88350 "FGFR1c ligand binding and activation, Taeniopygia guttata"
xref: Reactome:REACT_88621 "FGFR2 ligand binding and activation, Sus scrofa"
xref: Reactome:REACT_89576 "Signaling by FGFR, Taeniopygia guttata"
xref: Reactome:REACT_90511 "Signaling by FGFR, Danio rerio"
xref: Reactome:REACT_90558 "FGFR1 ligand binding and activation, Danio rerio"
xref: Reactome:REACT_90759 "FGFR ligand binding and activation, Gallus gallus"
xref: Reactome:REACT_90815 "FGFR ligand binding and activation, Mus musculus"
xref: Reactome:REACT_90948 "FGFR3c ligand binding and activation, Drosophila melanogaster"
xref: Reactome:REACT_91265 "FGFR ligand binding and activation, Bos taurus"
xref: Reactome:REACT_91601 "FGFR1c and Klotho ligand binding and activation, Rattus norvegicus"
xref: Reactome:REACT_91886 "FGFR2c ligand binding and activation, Xenopus tropicalis"
xref: Reactome:REACT_92480 "FGFR1b ligand binding and activation, Gallus gallus"
xref: Reactome:REACT_92745 "FGFR2c ligand binding and activation, Mus musculus"
xref: Reactome:REACT_93296 "Signaling by FGFR, Canis familiaris"
xref: Reactome:REACT_9390 "FGFR2 ligand binding and activation, Homo sapiens"
xref: Reactome:REACT_9396 "FGFR ligand binding and activation, Homo sapiens"
xref: Reactome:REACT_9400 "FGFR1b ligand binding and activation, Homo sapiens"
xref: Reactome:REACT_9413 "FGFR2c ligand binding and activation, Homo sapiens"
xref: Reactome:REACT_9416 "FGFR2b ligand binding and activation, Homo sapiens"
xref: Reactome:REACT_94238 "FGFR1c ligand binding and activation, Canis familiaris"
xref: Reactome:REACT_94371 "FGFR2b ligand binding and activation, Taeniopygia guttata"
xref: Reactome:REACT_94377 "Signaling by FGFR, Oryza sativa"
xref: Reactome:REACT_9439 "FGFR3 ligand binding and activation, Homo sapiens"
xref: Reactome:REACT_9452 "FGFR4 ligand binding and activation, Homo sapiens"
xref: Reactome:REACT_94582 "Signaling by FGFR, Dictyostelium discoideum"
xref: Reactome:REACT_9470 "Signaling by FGFR, Homo sapiens"
xref: Reactome:REACT_9483 "FGFR1 ligand binding and activation, Homo sapiens"
xref: Reactome:REACT_9484 "FGFR1c and Klotho ligand binding and activation, Homo sapiens"
xref: Reactome:REACT_9508 "FGFR3b ligand binding and activation, Homo sapiens"
xref: Reactome:REACT_9510 "FGFR3c ligand binding and activation, Homo sapiens"
xref: Reactome:REACT_95124 "FGFR1b ligand binding and activation, Bos taurus"
xref: Reactome:REACT_9515 "FGFR1c ligand binding and activation, Homo sapiens"
xref: Reactome:REACT_95314 "FGFR3c ligand binding and activation, Xenopus tropicalis"
xref: Reactome:REACT_96017 "FGFR1c and Klotho ligand binding and activation, Mus musculus"
xref: Reactome:REACT_96035 "FGFR1c ligand binding and activation, Danio rerio"
xref: Reactome:REACT_96057 "FGFR1b ligand binding and activation, Sus scrofa"
xref: Reactome:REACT_96369 "FGFR3c ligand binding and activation, Rattus norvegicus"
xref: Reactome:REACT_96442 "FGFR3b ligand binding and activation, Rattus norvegicus"
xref: Reactome:REACT_96467 "FGFR3 ligand binding and activation, Danio rerio"
xref: Reactome:REACT_97223 "FGFR1c and Klotho ligand binding and activation, Taeniopygia guttata"
xref: Reactome:REACT_97391 "FGFR1b ligand binding and activation, Canis familiaris"
xref: Reactome:REACT_98666 "FGFR4 ligand binding and activation, Mus musculus"
xref: Reactome:REACT_98769 "FGFR3 ligand binding and activation, Drosophila melanogaster"
xref: Reactome:REACT_98802 "FGFR3 ligand binding and activation, Taeniopygia guttata"
xref: Reactome:REACT_99452 "FGFR4 ligand binding and activation, Taeniopygia guttata"
xref: Reactome:REACT_99507 "FGFR2b ligand binding and activation, Mus musculus"
is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway
relationship: part_of GO:0044344 ! cellular response to fibroblast growth factor stimulus

[Term]
id: GO:0008544
name: epidermis development
namespace: biological_process
def: "The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species." [GOC:go_curators, UBERON:0001003]
synonym: "hypodermis development" RELATED [GOC:kmv, GOC:rk]
is_a: GO:0060429 ! epithelium development

[Term]
id: GO:0008545
name: JUN kinase kinase activity
namespace: molecular_function
def: "Catalysis of the phosphorylation of tyrosine and threonine residues in a c-Jun NH2-terminal kinase (JNK), a member of a subgroup of mitogen-activated protein kinases (MAPKs), which signal in response to cytokines and exposure to environmental stress. JUN kinase kinase (JNKK) is a dual-specificity protein kinase kinase and requires activation by a serine/threonine kinase JUN kinase kinase kinase." [GOC:bf, PMID:11057897, PMID:11790549]
synonym: "JNKK" EXACT []
xref: EC:2.7.11.-
xref: Reactome:REACT_103413 "Phosphorylation of human JNKs by activated MKK4/MKK7, Danio rerio"
xref: Reactome:REACT_112463 "Phosphorylation of human JNKs by activated MKK4/MKK7, Arabidopsis thaliana"
xref: Reactome:REACT_114469 "Phosphorylation of human JNKs by activated MKK4/MKK7, Dictyostelium discoideum"
xref: Reactome:REACT_114896 "Phosphorylation of human JNKs by activated MKK4/MKK7, Oryza sativa"
xref: Reactome:REACT_29782 "Phosphorylation of human JNKs by activated MKK4/MKK7, Xenopus tropicalis"
xref: Reactome:REACT_33106 "Phosphorylation of human JNKs by activated MKK4/MKK7, Taeniopygia guttata"
xref: Reactome:REACT_6896 "Phosphorylation of human JNKs by activated MKK4/MKK7, Homo sapiens"
xref: Reactome:REACT_80320 "Phosphorylation of human JNKs by activated MKK4/MKK7, Bos taurus"
xref: Reactome:REACT_83873 "Phosphorylation of human JNKs by activated MKK4/MKK7, Gallus gallus"
xref: Reactome:REACT_92449 "Phosphorylation of human JNKs by activated MKK4/MKK7, Canis familiaris"
xref: Reactome:REACT_94164 "Phosphorylation of human JNKs by activated MKK4/MKK7, Sus scrofa"
xref: Reactome:REACT_94971 "Phosphorylation of human JNKs by activated MKK4/MKK7, Mus musculus"
xref: Reactome:REACT_95219 "Phosphorylation of human JNKs by activated MKK4/MKK7, Rattus norvegicus"
xref: Reactome:REACT_99661 "Phosphorylation of human JNKs by activated MKK4/MKK7, Caenorhabditis elegans"
is_a: GO:0004708 ! MAP kinase kinase activity
relationship: part_of GO:0007257 ! activation of JUN kinase activity

[Term]
id: GO:0008546
name: obsolete microtubule/chromatin interaction
namespace: biological_process
def: "OBSOLETE. Physical interaction between microtubules and chromatin via DNA binding proteins." [PMID:10322137]
comment: This term was made obsolete because it represents a molecular function.
synonym: "microtubule/chromatin interaction" EXACT []
is_obsolete: true
consider: GO:0003677
consider: GO:0003682
consider: GO:0008017
consider: GO:0030674

[Term]
id: GO:0008547
name: obsolete protein-synthesizing GTPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. A GTPase involved in protein synthesis. In the initiation factor complex, it is IF-2b (98 kDa) that binds GTP and subsequently hydrolyzes it in prokaryotes. In eukaryotes, it is eIF-2 (150 kDa) that binds GTP. In the elongation phase, the GTP-hydrolyzing proteins are the EF-Tu polypeptide of the prokaryotic transfer factor (43 kDa), the eukaryotic elongation factor EF-1a (53 kDa), the prokaryotic EF-G (77 kDa), the eukaryotic EF-2 (70-110 kDa) and the signal recognition particle that play a role in endoplasmic reticulum protein synthesis (325 kDa). EF-Tu and EF1a catalyze binding of aminoacyl-tRNA to the ribosomal A-site, while EF-G and EF-2 catalyze the translocation of peptidyl-tRNA from the A-site to the P-site. GTPase activity is also involved in polypeptide release from the ribosome with the aid of the pRFs and eRFs." [EC:3.6.5.3, MetaCyc:3.6.1.48-RXN]
comment: This term was made obsolete because it represents a gene product.
synonym: "protein-synthesizing GTPase activity" EXACT []
is_obsolete: true
consider: GO:0003924
consider: GO:0006412
consider: GO:0008135

[Term]
id: GO:0008548
name: obsolete signal-recognition-particle GTPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. Activity is associated with the signal-recognition particle, a protein and RNA-containing structure involved in endoplasmic reticulum-associated protein synthesis." [EC:3.6.5.4, MetaCyc:3.6.1.49-RXN]
comment: This term was made obsolete because it represents a gene product.
synonym: "signal-recognition-particle GTPase activity" EXACT []
is_obsolete: true
consider: GO:0003924
consider: GO:0005786

[Term]
id: GO:0008549
name: obsolete dynamin GTPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. An enzyme that is involved in endocytosis and is instrumental in pinching off membrane vesicles." [EC:3.6.5.5, MetaCyc:3.6.1.50-RXN]
comment: This term was made obsolete because it represents a gene product.
synonym: "dynamin GTPase activity" EXACT []
synonym: "dynamine GTPase activity" EXACT []
is_obsolete: true
replaced_by: GO:0003924
consider: GO:0006897

[Term]
id: GO:0008550
name: obsolete tubulin GTPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. An intrinsic activity of alpha-tubulin involved in tubulin folding, division plane formation in prokaryotic cells and others." [EC:3.6.5.6, MetaCyc:3.6.1.51-RXN]
comment: This term was made obsolete because it represents a gene product.
synonym: "tubulin GTPase activity" EXACT []
is_obsolete: true
consider: GO:0003924
consider: GO:0007021

[Term]
id: GO:0008551
name: cadmium-exporting ATPase activity
namespace: molecular_function
alt_id: GO:0008561
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cd2+(in) -> ADP + phosphate + Cd2+(out)." [EC:3.6.3.3]
subset: gosubset_prok
synonym: "ATP phosphohydrolase (Cd2+-exporting)" EXACT [EC:3.6.3.3]
synonym: "cadmium exporting ATPase activity" EXACT []
synonym: "cadmium-translocating P-type ATPase activity" RELATED [EC:3.6.3.3]
synonym: "Cd(2+)-exporting ATPase activity" EXACT [EC:3.6.3.3]
synonym: "Cd2+-exporting ATPase activity" EXACT [EC:3.6.3.3]
xref: EC:3.6.3.3
xref: MetaCyc:3.6.3.3-RXN
xref: RHEA:12135
is_a: GO:0015086 ! cadmium ion transmembrane transporter activity
is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
is_a: GO:0019829 ! cation-transporting ATPase activity

[Term]
id: GO:0008552
name: obsolete zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: Me2+(in) + ATP = Me2+(out) + ADP + phosphate, where Me is Zn2+, Cd2+, Co2+, Ni2+ or Pb2+." [TC:3.A.3.6.2]
comment: This term was made obsolete because it represents more than one molecular function.
synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" EXACT []
is_obsolete: true
consider: GO:0005385
consider: GO:0015086
consider: GO:0015087
consider: GO:0015094
consider: GO:0015099
consider: GO:0015662

[Term]
id: GO:0008553
name: hydrogen-exporting ATPase activity, phosphorylative mechanism
namespace: molecular_function
def: "Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out). These transporters use a phosphorylative mechanism, which have a phosphorylated intermediate state during the ion transport cycle." [EC:3.6.3.6]
subset: gosubset_prok
synonym: "ATP phosphohydrolase (H+-exporting)" EXACT [EC:3.6.3.6]
synonym: "H(+)-exporting ATPase activity" BROAD [EC:3.6.3.6]
synonym: "H(+)-transporting ATPase activity" BROAD [EC:3.6.3.6]
synonym: "H+-exporting ATPase activity" EXACT [EC:3.6.3.6]
synonym: "H+-transporting ATPase" BROAD [EC:3.6.3.6]
synonym: "hydrogen exporting ATPase activity, phosphorylative mechanism" EXACT []
synonym: "hydrogen-/sodium-translocating ATPase activity" RELATED []
synonym: "proton transport ATPase activity" RELATED [EC:3.6.3.6]
synonym: "proton-exporting ATPase" RELATED [EC:3.6.3.6]
synonym: "proton-translocating ATPase activity" EXACT [EC:3.6.3.6]
synonym: "proton-translocating P-type ATPase activity" EXACT [EC:3.6.3.6]
synonym: "yeast plasma membrane ATPase" NARROW [EC:3.6.3.6]
synonym: "yeast plasma membrane H+-ATPase" NARROW [EC:3.6.3.6]
xref: EC:3.6.3.6
xref: MetaCyc:3.6.3.6-RXN
is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity
is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
is_a: GO:0036442 ! hydrogen-exporting ATPase activity

[Term]
id: GO:0008554
name: sodium-exporting ATPase activity, phosphorylative mechanism
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) -> ADP + phosphate + Na+(out); by a phosphorylative mechanism." [EC:3.6.3.7]
subset: gosubset_prok
synonym: "ATP phosphohydrolase (Na+-exporting)" EXACT [EC:3.6.3.7]
synonym: "hydrogen-/sodium-translocating ATPase activity" RELATED []
synonym: "Na(+)-exporting ATPase activity" EXACT [EC:3.6.3.7]
synonym: "Na(+)-transporting ATPase activity" BROAD [EC:3.6.3.7]
synonym: "Na+-exporting ATPase activity" EXACT [EC:3.6.3.7]
synonym: "Na+-transporting ATPase activity" EXACT [EC:3.6.3.7]
synonym: "sodium exporting ATPase activity, phosphorylative mechanism" EXACT []
synonym: "sodium transport ATPase activity" RELATED [EC:3.6.3.7]
synonym: "sodium-exporting ATPase activity" EXACT [EC:3.6.3.7]
synonym: "sodium-translocating P-type ATPase activity" RELATED [EC:3.6.3.7]
xref: EC:3.6.3.7
xref: MetaCyc:3.6.3.7-RXN
xref: RHEA:14636
is_a: GO:0015081 ! sodium ion transmembrane transporter activity
is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
is_a: GO:0019829 ! cation-transporting ATPase activity

[Term]
id: GO:0008555
name: chloride-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cl-(out) = ADP + phosphate + Cl-(in)." [EC:3.6.3.11]
subset: gosubset_prok
synonym: "ATP phosphohydrolase (Cl--importing)" EXACT [EC:3.6.3.11]
synonym: "chloride ABC transporter" NARROW []
synonym: "chloride transporting ATPase activity" EXACT []
synonym: "chloride-motive ATPase activity" EXACT [EC:3.6.3.11]
synonym: "chloride-translocating ATPase activity" EXACT [EC:3.6.3.11]
synonym: "Cl(-)-transporting ATPase activity" EXACT [EC:3.6.3.11]
synonym: "Cl--motive ATPase activity" EXACT [EC:3.6.3.11]
synonym: "Cl--translocating ATPase activity" EXACT [EC:3.6.3.11]
synonym: "Cl--transporting ATPase activity" EXACT [EC:3.6.3.11]
xref: EC:3.6.3.11
xref: MetaCyc:3.6.3.11-RXN
xref: RHEA:24131
is_a: GO:0015108 ! chloride transmembrane transporter activity
is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism

[Term]
id: GO:0008556
name: potassium-transporting ATPase activity
namespace: molecular_function
alt_id: GO:0015618
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in)." [EC:3.6.3.12]
subset: gosubset_prok
synonym: "ATP phosphohydrolase (K+-importing)" EXACT [EC:3.6.3.12]
synonym: "K(+)-importing ATPase activity" NARROW [EC:3.6.3.12]
synonym: "K(+)-transporting ATPase activity" EXACT [EC:3.6.3.12]
synonym: "K+-importing ATPase activity" EXACT [EC:3.6.3.12]
synonym: "K+-translocating Kdp-ATPase activity" EXACT [EC:3.6.3.12]
synonym: "K+-transporting ATPase activity" EXACT []
synonym: "k+-transporting ATPase activity" EXACT [EC:3.6.3.12]
synonym: "multi-subunit K+-transport ATPase" NARROW [EC:3.6.3.12]
synonym: "potassium ABC transporter" NARROW []
synonym: "potassium transporting ATPase activity" EXACT []
synonym: "potassium-importing ATPase activity" NARROW [EC:3.6.3.12]
synonym: "potassium-uptake-ATPase activity" EXACT []
xref: EC:3.6.3.12
xref: RHEA:16780
is_a: GO:0015079 ! potassium ion transmembrane transporter activity
is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
is_a: GO:0019829 ! cation-transporting ATPase activity

[Term]
id: GO:0008558
name: guanine-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + guanine(out) = ADP + phosphate + guanine(in)." [EC:3.6.3.37]
synonym: "ATP phosphohydrolase (guanine-importing)" EXACT [EC:3.6.3.37]
synonym: "guanine ABC transporter" NARROW []
xref: EC:3.6.3.37
xref: MetaCyc:3.6.3.37-RXN
xref: RHEA:20835
is_a: GO:0015208 ! guanine transmembrane transporter activity
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances

[Term]
id: GO:0008559
name: xenobiotic-transporting ATPase activity
namespace: molecular_function
alt_id: GO:0005226
alt_id: GO:0008560
def: "Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out)." [EC:3.6.3.44]
subset: gosubset_prok
synonym: "ATP phosphohydrolase (steroid-exporting)" EXACT [EC:3.6.3.44]
synonym: "ATP phosphohydrolase (xenobiotic-exporting)" EXACT [EC:3.6.3.44]
synonym: "MDR protein" RELATED [EC:3.6.3.44]
synonym: "multidrug resistance exporter" RELATED []
synonym: "multidrug-resistance protein" RELATED []
synonym: "P-glycoprotein" RELATED []
synonym: "PDR protein" RELATED [EC:3.6.3.44]
synonym: "pleiotropic-drug-resistance protein" RELATED [EC:3.6.3.44]
synonym: "steroid ABC transporter" NARROW []
synonym: "steroid-transporting ATPase activity" EXACT []
synonym: "xenobiotic ABC transporter" NARROW []
xref: EC:3.6.3.44
xref: MetaCyc:3.6.3.44-RXN
xref: Reactome:REACT_111164 "ABCA8, B1 and B5 mediate xenobiotic efflux, Homo sapiens"
is_a: GO:0015238 ! drug transmembrane transporter activity
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances
is_a: GO:0042910 ! xenobiotic transporter activity

[Term]
id: GO:0008563
name: obsolete alpha-factor sex pheromone exporter
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + alpha-factor(in) = ADP + phosphate + alpha-factor(out). The export of the alpha-factor sex pheromone by an ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains, that does not undergo phosphorylation during the transport process." [EC:3.6.3.48]
comment: This term was made obsolete because this function does not exist; alpha-factor is secreted by the classical secretion pathway and not exported.
synonym: "alpha-factor sex pheromone exporter" EXACT []
synonym: "alpha-factor-transporting ATPase" RELATED []
is_obsolete: true

[Term]
id: GO:0008564
name: protein-exporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + protein+(in) -> ADP + phosphate + protein+(out); drives the concomitant secretion of proteins." [EC:3.6.3.50]
synonym: "ATP phosphohydrolase (protein-secreting)" EXACT [EC:3.6.3.50]
synonym: "protein-secreting ATPase activity" EXACT []
xref: EC:3.6.3.50
xref: MetaCyc:3.6.3.50-RXN
is_a: GO:0015462 ! protein-transmembrane transporting ATPase activity

[Term]
id: GO:0008565
name: protein transporter activity
namespace: molecular_function
alt_id: GO:0015463
def: "Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_yeast
subset: gosubset_prok
synonym: "enzyme transporter activity" NARROW []
synonym: "holin" RELATED []
synonym: "protein carrier activity" EXACT []
synonym: "protein transport chaperone" NARROW [GOC:dph, GOC:mah, GOC:tb]
synonym: "secretin" RELATED []
is_a: GO:0022892 ! substrate-specific transporter activity
relationship: part_of GO:0015031 ! protein transport

[Term]
id: GO:0008566
name: mitochondrial protein-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of proteins into the mitochondrion via the mitochondrial inner membrane translocase complex." [EC:3.6.3.51]
comment: See also the cellular component term 'mitochondrial inner membrane presequence translocase complex ; GO:0005744'.
synonym: "ATP phosphohydrolase (mitochondrial protein-importing) activity" EXACT [EC:3.6.3.51]
xref: EC:3.6.3.51
xref: MetaCyc:3.6.3.51-RXN
is_a: GO:0015462 ! protein-transmembrane transporting ATPase activity

[Term]
id: GO:0008567
name: obsolete dynein ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP by dynein that provides the energy for the movement of organelles (endosomes, lysosomes, mitochondria) along microtubules to the centrosome." [EC:3.6.4.2]
comment: This term was made obsolete because it represents a class of gene products, and its definition incorporates process information.
synonym: "dynein ATPase activity" EXACT []
is_obsolete: true
consider: GO:0003777
consider: GO:0007018

[Term]
id: GO:0008568
name: microtubule-severing ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP." [EC:3.6.4.3, PMID:10910766]
comment: See also the cellular component term 'katanin complex ; GO:0008352'.
synonym: "ATP phosphohydrolase (tubulin-dimerizing)" EXACT [EC:3.6.4.3]
synonym: "katanin activity" NARROW [EC:3.6.4.3]
xref: EC:3.6.4.3
xref: MetaCyc:3.6.4.3-RXN
is_a: GO:0042623 ! ATPase activity, coupled

[Term]
id: GO:0008569
name: ATP-dependent microtubule motor activity, minus-end-directed
namespace: molecular_function
def: "Catalysis of movement along a microtubule toward the minus end, coupled to the hydrolysis of ATP." [EC:3.6.4.5, GOC:mah, GOC:vw]
synonym: "ATP-dependent minus-end-directed microtubule motor activity" EXACT []
synonym: "kinesin ATP phosphohydrolase (minus-end-directed)" EXACT [EC:3.6.4.5]
synonym: "minus-end-directed ATP-dependent microtubule motor activity" EXACT []
synonym: "minus-end-directed kinesin ATPase activity" EXACT []
synonym: "minus-end-directed microtubule motor activity" BROAD []
xref: EC:3.6.4.5
xref: MetaCyc:3.6.4.5-RXN
is_a: GO:0016887 ! ATPase activity
is_a: GO:1990939 ! ATP-dependent microtubule motor activity

[Term]
id: GO:0008570
name: obsolete myosin ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP by myosin that provides the energy for actomyosin contraction." [EC:3.6.4.1]
comment: This term was made obsolete because it represents a class of gene products, and its definition incorporates process information.
synonym: "myosin ATPase activity" EXACT []
is_obsolete: true
replaced_by: GO:0000146
consider: GO:0030048

[Term]
id: GO:0008571
name: obsolete non-chaperonin molecular chaperone ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. This is a highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. They comprise a number of heat-shock-cognate proteins. They are also active in clathrin uncoating and in the oligomerization of actin." [EC:3.6.4.10]
comment: This term was made obsolete because it represents a class of gene products.
synonym: "non-chaperonin molecular chaperone ATPase activity" EXACT []
is_obsolete: true
replaced_by: GO:0042623
consider: GO:0006457

[Term]
id: GO:0008572
name: obsolete nucleoplasmin ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP required for the ATP-dependent assembly of nucleosome cores, in decondensation of sperm chromatin and in other histone-involving processes." [EC:3.6.4.11]
comment: This term was made obsolete because it represents a class of gene products, and its definition incorporates process information.
synonym: "nucleoplasmin ATPase activity" EXACT []
is_obsolete: true
replaced_by: GO:0042623
consider: GO:0006333

[Term]
id: GO:0008573
name: obsolete peroxisome-assembly ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. ATP hydrolysis to import and assemble peroxisome components into the organelle." [EC:3.6.4.7]
comment: This term was made obsolete because it incorporates process information.
synonym: "peroxisome-assembly ATPase activity" EXACT []
is_obsolete: true
replaced_by: GO:0042623
consider: GO:0007031

[Term]
id: GO:0008574
name: ATP-dependent microtubule motor activity, plus-end-directed
namespace: molecular_function
def: "Catalysis of movement along a microtubule toward the plus end, coupled to the hydrolysis of ATP." [EC:3.6.4.4, GOC:vw]
synonym: "ATP-dependent plus-end-directed microtubule motor activity" EXACT []
synonym: "kinesin activity" RELATED [EC:3.6.4.4]
synonym: "kinesin ATP phosphohydrolase (plus-end-directed)" EXACT [EC:3.6.4.4]
synonym: "plus-end-directed ATP-dependent microtubule motor activity" EXACT []
synonym: "plus-end-directed kinesin ATPase activity" EXACT []
synonym: "plus-end-directed microtubule motor activity" BROAD []
xref: EC:3.6.4.4
xref: MetaCyc:3.6.4.4-RXN
is_a: GO:0016887 ! ATPase activity
is_a: GO:1990939 ! ATP-dependent microtubule motor activity

[Term]
id: GO:0008575
name: obsolete proteasome ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP for channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome." [EC:3.6.4.8]
comment: This term was made obsolete because it mentions a component term in the term text string.
synonym: "proteasome ATPase activity" EXACT []
is_obsolete: true
consider: GO:0016887

[Term]
id: GO:0008576
name: obsolete vesicle-fusing ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP by an AAA-ATPase, involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments." [EC:3.6.4.6]
comment: This term was made obsolete because it incorporates process information.
synonym: "vesicle-fusing ATPase activity" EXACT []
is_obsolete: true
replaced_by: GO:0042623
consider: GO:0016192
consider: GO:0061025

[Term]
id: GO:0008579
name: JUN kinase phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: JUN kinase serine/threonine/tyrosine phosphate + H2O = JUN kinase serine/threonine/tyrosine + phosphate." [GOC:mah]
xref: EC:3.1.3.-
is_a: GO:0008138 ! protein tyrosine/serine/threonine phosphatase activity

[Term]
id: GO:0008580
name: obsolete cytoskeletal regulator activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because 'cytoskeleton' is not an activity, and regulation of its distribution or modification belongs in the process ontology.
synonym: "cytoskeletal regulator activity" EXACT []
is_obsolete: true
consider: GO:0007010

[Term]
id: GO:0008581
name: obsolete ubiquitin-specific protease 5 activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of the Gly76-Lys48 isopeptide bond of polyubiquitin." [ISBN:0120793709, MEROPS:c19p001]
comment: This term was made obsolete because it represents a gene product.
synonym: "ubiquitin isopeptidase T activity" EXACT []
synonym: "ubiquitin-specific protease 5 activity" EXACT []
is_obsolete: true
replaced_by: GO:0004221

[Term]
id: GO:0008582
name: regulation of synaptic growth at neuromuscular junction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions." [GOC:go_curators]
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:0051963 ! regulation of synapse assembly
is_a: GO:1904396 ! regulation of neuromuscular junction development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051124 ! synaptic growth at neuromuscular junction
relationship: regulates GO:0051124 ! synaptic growth at neuromuscular junction

[Term]
id: GO:0008583
name: mystery cell differentiation
namespace: biological_process
def: "The process in which an undifferentiated cell acquires the features of a mystery cell. The mystery cells are a precluster of cells that emerge from the compound eye morphogenetic furrow, normally positioned between R3 and R4. They then disappear into the surrounding pool of undifferentiated cells and have no known fate in the mature ommatidium. An example of this process is found in Drosophila melanogaster." [ISBN:0632030488, PMID:1295747]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0001745 ! compound eye morphogenesis

[Term]
id: GO:0008584
name: male gonad development
namespace: biological_process
def: "The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure." [GOC:jid]
synonym: "testicular development" EXACT [GOC:sl]
synonym: "testis development" EXACT [GOC:sl]
is_a: GO:0008406 ! gonad development
relationship: part_of GO:0046546 ! development of primary male sexual characteristics

[Term]
id: GO:0008585
name: female gonad development
namespace: biological_process
alt_id: GO:0061039
def: "The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:tb]
synonym: "ovarian development" RELATED [GOC:sl]
synonym: "ovary development" RELATED [GOC:sl]
is_a: GO:0008406 ! gonad development
relationship: part_of GO:0046545 ! development of primary female sexual characteristics

[Term]
id: GO:0008586
name: imaginal disc-derived wing vein morphogenesis
namespace: biological_process
def: "The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized." [GOC:mtg_sensu]
synonym: "wing vein morphogenesis" EXACT []
is_a: GO:0009886 ! post-embryonic morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis

[Term]
id: GO:0008587
name: imaginal disc-derived wing margin morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the imaginal disc-derived wing margin are generated and organized. The wing margin is a strip of cells in the third instar disc at the boundary between the presumptive dorsal and ventral surfaces of the wing blade." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238]
comment: See also the fly_anatomy.ontology term 'wing margin ; FBbt:00005378'.
synonym: "wing margin morphogenesis" EXACT []
is_a: GO:0009886 ! post-embryonic morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis

[Term]
id: GO:0008588
name: release of cytoplasmic sequestered NF-kappaB
namespace: biological_process
def: "The release of NF-kappaB from specific molecules in the cytoplasm to which it was bound, thereby allowing its translocation into the nucleus." [GOC:jl]
synonym: "activation of NF-kappa B" RELATED []
synonym: "negative regulation of cytoplasmic NF-kappaB retention" RELATED []
synonym: "negative regulation of cytoplasmic NF-kappaB sequestering" RELATED []
synonym: "negative regulation of cytoplasmic NF-kappaB sequestration" RELATED []
synonym: "negative regulation of cytoplasmic NF-kappaB storage" RELATED []
synonym: "release of NF-kappaB sequestered in cytoplasm" EXACT []
synonym: "release of NF-kappaB stored in cytoplasm" EXACT []
is_a: GO:0042346 ! positive regulation of NF-kappaB import into nucleus
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0065008 ! regulation of biological quality
is_a: GO:1903828 ! negative regulation of cellular protein localization
relationship: negatively_regulates GO:0007253 ! cytoplasmic sequestering of NF-kappaB
relationship: part_of GO:0007249 ! I-kappaB kinase/NF-kappaB signaling

[Term]
id: GO:0008589
name: regulation of smoothened signaling pathway
namespace: biological_process
alt_id: GO:0007226
alt_id: GO:0043109
def: "Any process that modulates the frequency, rate or extent of smoothened signaling." [GOC:go_curators]
synonym: "regulation of hedgehog signaling pathway" EXACT [GOC:bf, GOC:ecd]
synonym: "regulation of hh signaling pathway" EXACT [GOC:bf, GOC:ecd]
synonym: "regulation of smoothened activity" RELATED []
synonym: "regulation of smoothened by patched" RELATED []
synonym: "regulation of smoothened receptor activity by patched" RELATED []
synonym: "regulation of smoothened signalling pathway" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007224 ! smoothened signaling pathway
relationship: regulates GO:0007224 ! smoothened signaling pathway

[Term]
id: GO:0008591
name: regulation of Wnt signaling pathway, calcium modulating pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC)." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "regulation of frizzled-2 signaling pathway" EXACT []
synonym: "regulation of frizzled-2 signalling pathway" EXACT []
synonym: "regulation of Wnt receptor signaling pathway, calcium modulating pathway" EXACT []
synonym: "regulation of Wnt-activated signaling pathway, calcium modulating pathway" EXACT [GOC:signaling]
is_a: GO:2000050 ! regulation of non-canonical Wnt signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007223 ! Wnt signaling pathway, calcium modulating pathway
relationship: regulates GO:0007223 ! Wnt signaling pathway, calcium modulating pathway

[Term]
id: GO:0008592
name: regulation of Toll signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the Tl signaling pathway." [GOC:go_curators]
synonym: "regulation of Tl signaling pathway" EXACT []
synonym: "regulation of Tl signalling pathway" EXACT []
synonym: "regulation of Toll signalling pathway" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008063 ! Toll signaling pathway
relationship: regulates GO:0008063 ! Toll signaling pathway

[Term]
id: GO:0008593
name: regulation of Notch signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]
synonym: "regulation of N signaling pathway" EXACT []
synonym: "regulation of N signalling pathway" EXACT []
synonym: "regulation of Notch signalling pathway" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007219 ! Notch signaling pathway
relationship: regulates GO:0007219 ! Notch signaling pathway

[Term]
id: GO:0008594
name: photoreceptor cell morphogenesis
namespace: biological_process
def: "The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster." [GOC:jid, GOC:mah]
synonym: "photoreceptor development" RELATED []
is_a: GO:0048667 ! cell morphogenesis involved in neuron differentiation
relationship: part_of GO:0042461 ! photoreceptor cell development

[Term]
id: GO:0008595
name: anterior/posterior axis specification, embryo
namespace: biological_process
def: "The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
synonym: "anterior/posterior axis determination, embryo" RELATED [GOC:dph]
is_a: GO:0000578 ! embryonic axis specification
is_a: GO:0009948 ! anterior/posterior axis specification
relationship: part_of GO:0007351 ! tripartite regional subdivision

[Term]
id: GO:0008597
name: calcium-dependent protein serine/threonine phosphatase regulator activity
namespace: molecular_function
def: "Modulation of the activity of the enzyme calcium-dependent protein serine/threonine phosphatase." [EC:3.1.3.16, GOC:ai]
synonym: "calcium-dependent protein serine/threonine phosphatase, intrinsic regulator activity" NARROW []
xref: Reactome:REACT_101560 "Activation of BAD by calcineurin, Sus scrofa"
xref: Reactome:REACT_113351 "Activation of BAD by calcineurin, Xenopus tropicalis"
xref: Reactome:REACT_113411 "Activation of BAD by calcineurin, Rattus norvegicus"
xref: Reactome:REACT_1663 "Activation of BAD by calcineurin, Homo sapiens"
xref: Reactome:REACT_29918 "Activation of BAD by calcineurin, Mus musculus"
xref: Reactome:REACT_84991 "Activation of BAD by calcineurin, Bos taurus"
xref: Reactome:REACT_95878 "Activation of BAD by calcineurin, Danio rerio"
is_a: GO:0019888 ! protein phosphatase regulator activity
relationship: regulates GO:0004723 ! calcium-dependent protein serine/threonine phosphatase activity

[Term]
id: GO:0008599
name: protein phosphatase type 1 regulator activity
namespace: molecular_function
def: "Modulation of the activity of the enzyme protein phosphatase type 1." [GOC:ai]
synonym: "protein phosphatase type 1, intrinsic regulator activity" NARROW []
xref: Reactome:REACT_103270 "DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function, Rattus norvegicus"
xref: Reactome:REACT_110300 "DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function, Bos taurus"
xref: Reactome:REACT_15496 "DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function, Homo sapiens"
xref: Reactome:REACT_47959 "DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function, Canis familiaris"
xref: Reactome:REACT_77917 "DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function, Sus scrofa"
xref: Reactome:REACT_78354 "DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function, Mus musculus"
is_a: GO:0019888 ! protein phosphatase regulator activity
relationship: has_part GO:0008157 ! protein phosphatase 1 binding

[Term]
id: GO:0008601
name: protein phosphatase type 2A regulator activity
namespace: molecular_function
def: "Modulation of the activity of the enzyme protein phosphatase type 2A." [GOC:ai]
synonym: "protein phosphatase 2 regulator activity" RELATED [GOC:dph, GOC:rl]
synonym: "protein phosphatase 2, intrinsic regulator activity" RELATED [GOC:dph, GOC:rl]
synonym: "protein phosphatase type 2A, intrinsic regulator activity" NARROW []
is_a: GO:0019888 ! protein phosphatase regulator activity
relationship: has_part GO:0051721 ! protein phosphatase 2A binding
relationship: part_of GO:0034047 ! regulation of protein phosphatase type 2A activity

[Term]
id: GO:0008603
name: cAMP-dependent protein kinase regulator activity
namespace: molecular_function
def: "Modulation of the activity of the enzyme cAMP-dependent protein kinase." [GOC:ai]
subset: gosubset_prok
synonym: "3',5' cAMP-dependent protein kinase regulator activity" EXACT []
synonym: "3',5'-cAMP-dependent protein kinase regulator activity" EXACT []
synonym: "adenosine 3',5'-cyclophosphate-dependent protein kinase regulator activity" EXACT []
synonym: "cAMP-dependent protein kinase, intrinsic regulator activity" NARROW []
synonym: "cyclic AMP-dependent protein kinase regulator activity" EXACT []
is_a: GO:0019887 ! protein kinase regulator activity
relationship: regulates GO:0004691 ! cAMP-dependent protein kinase activity

[Term]
id: GO:0008605
name: obsolete protein kinase CK2 regulator activity
namespace: molecular_function
def: "OBSOLETE. Modulation of the activity of the enzyme protein kinase CK2." [GOC:ai]
comment: This term was made obsolete because it represents a regulator of an obsolete molecular function.
synonym: "casein kinase II, regulator" EXACT []
synonym: "protein kinase CK2 regulator activity" EXACT []
synonym: "protein kinase CK2, intrinsic regulator activity" NARROW []
is_obsolete: true
replaced_by: GO:0019887

[Term]
id: GO:0008607
name: phosphorylase kinase regulator activity
namespace: molecular_function
def: "Modulation of the activity of the enzyme phosphorylase kinase." [EC:2.7.11.19]
synonym: "phosphorylase kinase, intrinsic regulator activity" NARROW []
xref: EC:2.7.1.-
is_a: GO:0019887 ! protein kinase regulator activity
relationship: regulates GO:0004689 ! phosphorylase kinase activity

[Term]
id: GO:0008608
name: attachment of spindle microtubules to kinetochore
namespace: biological_process
alt_id: GO:0051313
def: "The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex." [GOC:vw, PMID:10322137]
comment: This class covers all attachments of spindle microtubules to the kinetochore, including the many incorrect attachments which initially form and are later corrected to stable attachments with the correct orientation for segregation to procede (sister chromatid biorientation).
synonym: "amphotelic attachment" RELATED []
synonym: "attachment of spindle microtubules to chromosome" EXACT []
synonym: "bipolar attachment" RELATED []
synonym: "kinetochore microtubule interaction" BROAD []
synonym: "kinetochore-microtubule attachment" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "kinetochore-microtubule interaction" BROAD []
synonym: "microtubule anchoring at kinetochore" EXACT []
synonym: "microtubule and chromosome interaction" BROAD []
synonym: "microtubule and kinetochore interaction" RELATED []
synonym: "microtubule capture" NARROW []
synonym: "spindle chromosome attachment" EXACT []
synonym: "spindle kinetochore attachment" EXACT []
synonym: "spindle-chromosome interaction" BROAD []
is_a: GO:0022402 ! cell cycle process
relationship: has_part GO:0008017 ! microtubule binding
relationship: part_of GO:0098813 ! nuclear chromosome segregation

[Term]
id: GO:0008609
name: alkylglycerone-phosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-acyl-glycerone 3-phosphate + a long-chain alcohol = 1-alkyl-glycerone 3-phosphate + a long-chain acid anion." [EC:2.5.1.26]
subset: gosubset_prok
synonym: "1-acyl-glycerone-3-phosphate:long-chain-alcohol O-3-phospho-2-oxopropanyltransferase activity" EXACT [EC:2.5.1.26]
synonym: "alkyl DHAP synthetase activity" EXACT [EC:2.5.1.26]
synonym: "alkyl-DHAP" RELATED [EC:2.5.1.26]
synonym: "alkyl-DHAP synthase activity" EXACT [EC:2.5.1.26]
synonym: "alkyldihydroxyacetone phosphate synthetase activity" EXACT [EC:2.5.1.26]
synonym: "alkyldihydroxyacetonephosphate synthase activity" EXACT [EC:2.5.1.26]
synonym: "DHAP-AT" RELATED [EC:2.5.1.26]
synonym: "dihydroxyacetone-phosphate acyltransferase activity" EXACT [EC:2.5.1.26]
xref: EC:2.5.1.26
xref: MetaCyc:ALKYLGLYCERONE-PHOSPHATE-SYNTHASE-RXN
xref: Reactome:REACT_109489 "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate, Drosophila melanogaster"
xref: Reactome:REACT_114920 "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate, Escherichia coli"
xref: Reactome:REACT_115040 "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate, Mycobacterium tuberculosis"
xref: Reactome:REACT_16930 "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate, Homo sapiens"
xref: Reactome:REACT_29717 "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate, Taeniopygia guttata"
xref: Reactome:REACT_33247 "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate, Xenopus tropicalis"
xref: Reactome:REACT_34740 "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate, Canis familiaris"
xref: Reactome:REACT_77060 "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate, Gallus gallus"
xref: Reactome:REACT_87956 "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate, Rattus norvegicus"
xref: Reactome:REACT_88366 "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate, Bos taurus"
xref: Reactome:REACT_89140 "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate, Dictyostelium discoideum"
xref: Reactome:REACT_92287 "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate, Danio rerio"
xref: Reactome:REACT_93097 "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate, Caenorhabditis elegans"
xref: Reactome:REACT_96570 "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate, Sus scrofa"
xref: Reactome:REACT_99406 "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate, Mus musculus"
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0008610
name: lipid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]
subset: gosubset_prok
synonym: "lipid anabolism" EXACT []
synonym: "lipid biosynthesis" EXACT []
synonym: "lipid formation" EXACT []
synonym: "lipid synthesis" EXACT []
synonym: "lipogenesis" EXACT [GOC:sl]
is_a: GO:0006629 ! lipid metabolic process
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:1901576 ! organic substance biosynthetic process

[Term]
id: GO:0008611
name: ether lipid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ether lipids, lipids that contain (normally) one lipid alcohol in ether linkage to one of the carbon atoms (normally C-1) of glycerol." [GOC:ma, ISBN:0198547684, PMID:15337120]
subset: gosubset_prok
synonym: "ether lipid anabolism" EXACT []
synonym: "ether lipid biosynthesis" EXACT []
synonym: "ether lipid formation" EXACT []
synonym: "ether lipid synthesis" EXACT []
synonym: "plasmalogen biosynthetic process" NARROW []
xref: Reactome:REACT_101030 "Plasmalogen biosynthesis, Drosophila melanogaster"
xref: Reactome:REACT_101440 "Plasmalogen biosynthesis, Mus musculus"
xref: Reactome:REACT_106363 "Plasmalogen biosynthesis, Danio rerio"
xref: Reactome:REACT_112332 "Plasmalogen biosynthesis, Mycobacterium tuberculosis"
xref: Reactome:REACT_112578 "Plasmalogen biosynthesis, Escherichia coli"
xref: Reactome:REACT_1407 "Plasmalogen biosynthesis, Homo sapiens"
xref: Reactome:REACT_77542 "Plasmalogen biosynthesis, Arabidopsis thaliana"
xref: Reactome:REACT_78949 "Plasmalogen biosynthesis, Gallus gallus"
xref: Reactome:REACT_79623 "Plasmalogen biosynthesis, Rattus norvegicus"
xref: Reactome:REACT_80390 "Plasmalogen biosynthesis, Canis familiaris"
xref: Reactome:REACT_80482 "Plasmalogen biosynthesis, Oryza sativa"
xref: Reactome:REACT_82515 "Plasmalogen biosynthesis, Dictyostelium discoideum"
xref: Reactome:REACT_83759 "Plasmalogen biosynthesis, Sus scrofa"
xref: Reactome:REACT_95031 "Plasmalogen biosynthesis, Xenopus tropicalis"
xref: Reactome:REACT_95689 "Plasmalogen biosynthesis, Caenorhabditis elegans"
xref: Reactome:REACT_96985 "Plasmalogen biosynthesis, Bos taurus"
xref: Reactome:REACT_99920 "Plasmalogen biosynthesis, Taeniopygia guttata"
is_a: GO:0046485 ! ether lipid metabolic process
is_a: GO:0046504 ! glycerol ether biosynthetic process
is_a: GO:0097384 ! cellular lipid biosynthetic process

[Term]
id: GO:0008612
name: peptidyl-lysine modification to peptidyl-hypusine
namespace: biological_process
alt_id: GO:0046515
def: "The modification of peptidyl-lysine to form hypusine, peptidyl-N6-(4-amino-2-hydroxybutyl)-L-lysine." [GOC:ma, ISBN:0198547684, RESID:AA0116]
subset: gosubset_prok
synonym: "hypusine anabolism" EXACT []
synonym: "hypusine anabolism from peptidyl-lysine" EXACT []
synonym: "hypusine biosynthesis" EXACT []
synonym: "hypusine biosynthetic process" EXACT []
synonym: "hypusine biosynthetic process from peptidyl-lysine" EXACT []
synonym: "hypusine formation" EXACT []
synonym: "hypusine formation from peptidyl-lysine" EXACT []
synonym: "hypusine synthesis" EXACT []
synonym: "hypusine synthesis from peptidyl-lysine" EXACT []
synonym: "protein hypusination" EXACT []
xref: Reactome:REACT_102099 "Hypusine synthesis from eIF5A-lysine, Rattus norvegicus"
xref: Reactome:REACT_104705 "Hypusine synthesis from eIF5A-lysine, Danio rerio"
xref: Reactome:REACT_109457 "Hypusine synthesis from eIF5A-lysine, Xenopus tropicalis"
xref: Reactome:REACT_114795 "Hypusine synthesis from eIF5A-lysine, Caenorhabditis elegans"
xref: Reactome:REACT_12469 "Hypusine synthesis from eIF5A-lysine, Homo sapiens"
xref: Reactome:REACT_30897 "Hypusine synthesis from eIF5A-lysine, Drosophila melanogaster"
xref: Reactome:REACT_31464 "Hypusine synthesis from eIF5A-lysine, Schizosaccharomyces pombe"
xref: Reactome:REACT_32122 "Hypusine synthesis from eIF5A-lysine, Sus scrofa"
xref: Reactome:REACT_33574 "Hypusine synthesis from eIF5A-lysine, Dictyostelium discoideum"
xref: Reactome:REACT_82132 "Hypusine synthesis from eIF5A-lysine, Canis familiaris"
xref: Reactome:REACT_86108 "Hypusine synthesis from eIF5A-lysine, Mus musculus"
xref: Reactome:REACT_89856 "Hypusine synthesis from eIF5A-lysine, Gallus gallus"
xref: Reactome:REACT_91402 "Hypusine synthesis from eIF5A-lysine, Oryza sativa"
xref: Reactome:REACT_91675 "Hypusine synthesis from eIF5A-lysine, Taeniopygia guttata"
xref: Reactome:REACT_94771 "Hypusine synthesis from eIF5A-lysine, Saccharomyces cerevisiae"
xref: Reactome:REACT_95055 "Hypusine synthesis from eIF5A-lysine, Arabidopsis thaliana"
xref: Reactome:REACT_99762 "Hypusine synthesis from eIF5A-lysine, Bos taurus"
xref: RESID:AA0116
is_a: GO:0018205 ! peptidyl-lysine modification
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0008613
name: diuretic hormone activity
namespace: molecular_function
def: "The action characteristic of a diuretic hormone, any peptide hormone that, upon receptor binding, regulates water balance and fluid secretion." [GOC:mah, InterPro:IPR003621, PMID:8618894]
is_a: GO:0005179 ! hormone activity

[Term]
id: GO:0008614
name: pyridoxine metabolic process
namespace: biological_process
alt_id: GO:0006773
def: "The chemical reactions and pathways involving pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [CHEBI:16709, GOC:curators]
subset: gosubset_prok
synonym: "pyridoxine metabolism" EXACT []
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0042816 ! vitamin B6 metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process

[Term]
id: GO:0008615
name: pyridoxine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds." [GOC:ai]
subset: gosubset_prok
synonym: "pyridoxine anabolism" EXACT []
synonym: "pyridoxine biosynthesis" EXACT []
synonym: "pyridoxine formation" EXACT []
synonym: "pyridoxine synthesis" EXACT []
is_a: GO:0008614 ! pyridoxine metabolic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0042819 ! vitamin B6 biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process

[Term]
id: GO:0008616
name: queuosine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of queuosines, any of a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "queuosine anabolism" EXACT []
synonym: "queuosine biosynthesis" EXACT []
synonym: "queuosine formation" EXACT []
synonym: "queuosine synthesis" EXACT []
is_a: GO:0042455 ! ribonucleoside biosynthetic process
is_a: GO:0046116 ! queuosine metabolic process

[Term]
id: GO:0008617
name: guanosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving guanine, guanine riboside, a nucleoside with a wide species distribution." [ISBN:0198506732]
subset: gosubset_prok
synonym: "guanosine metabolism" EXACT []
is_a: GO:1901068 ! guanosine-containing compound metabolic process

[Term]
id: GO:0008618
name: 7-methylguanosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 7-methylguanosine, a modified nucleoside that forms a cap at the 5'-terminus of eukaryotic mRNA." [ISBN:0198506732]
subset: gosubset_prok
synonym: "7-methylguanosine metabolism" EXACT []
is_a: GO:1901068 ! guanosine-containing compound metabolic process

[Term]
id: GO:0008619
name: obsolete RHEB small monomeric GTPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47, PMID:12893813]
comment: This term was made obsolete because it represents a gene product.
synonym: "RHEB small monomeric GTPase activity" EXACT []
is_obsolete: true
replaced_by: GO:0003924
consider: GO:0001558
consider: GO:0051726

[Term]
id: GO:0008622
name: epsilon DNA polymerase complex
namespace: cellular_component
def: "A heterotetrameric DNA polymerase complex that catalyzes processive DNA synthesis in the absence of PCNA, but is further stimulated in the presence of PCNA. The complex contains a large catalytic subunit and three small subunits, and is best characterized in Saccharomyces, in which the subunits are named Pol2p, Dpb2p, Dpb3p, and Dpb4p. Some evidence suggests that DNA polymerase epsilon is the leading strand polymerase; it is also involved in nucleotide-excision repair and mismatch repair." [PMID:15814431, PMID:9745046]
synonym: "DNA polymerase epsilon complex" EXACT [CORUM:420]
is_a: GO:0042575 ! DNA polymerase complex
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000109 ! nucleotide-excision repair complex
relationship: part_of GO:0043601 ! nuclear replisome

[Term]
id: GO:0008623
name: CHRAC
namespace: cellular_component
alt_id: GO:0016588
def: "An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals, Isw2 in S. cerevisiae), an ACF1 homolog, and additional small histone fold subunits (generally two of these, but Xenopus has only one and some additional non-conserved subunits). CHRAC plays roles in the regulation of RNA polymerase II transcription and in DNA replication and repair." [GOC:bf, GOC:krc, PMID:15284901, PMID:16568949, PMID:21810179, PMID:9252192]
synonym: "chromatin accessibility complex" EXACT []
synonym: "ISW2 complex" NARROW []
is_a: GO:0031010 ! ISWI-type complex

[Term]
id: GO:0008625
name: extrinsic apoptotic signaling pathway via death domain receptors
namespace: biological_process
def: "A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered." [GOC:mah, GOC:mtg_apoptosis]
comment: Gene products that may be annotated to this term include: 1) ligands such as FASL; 2) receptors such as FAS/CD95 (though care should be taken because FAS can also act as a non-apoptotic signal transducer); 3) signaling molecules such as FADD (FAS-associated protein with a death domain), cIAPs (cellular inhibitor of apoptosis proteins), c-FLIPs and caspases 8 and 10. Examples are TWEAK (TNF12) and FN14 (TNFRSF12A) (UniProt symbols O43508 and Q9NP84) in PMID:21525013.
synonym: "death receptor-mediated apoptosis" NARROW []
synonym: "induction of apoptosis via death domain receptors" RELATED []
synonym: "induction of apoptosis via death receptors" EXACT [GOC:mah]
is_a: GO:0097191 ! extrinsic apoptotic signaling pathway

[Term]
id: GO:0008626
name: granzyme-mediated apoptotic signaling pathway
namespace: biological_process
def: "A series of molecular signals induced by granzymes which triggers the apoptotic death of a cell. The pathway starts with reception of a granzyme signal, and ends when the execution phase of apoptosis is triggered. Granzymes are serine proteases that are secreted by cytotoxic T cells and natural killer cells to induce apoptosis in target cells." [GOC:mtg_apoptosis, PMID:17158907]
synonym: "apoptotic signaling pathway in response to granzyme" RELATED []
synonym: "induction of apoptosis by granzyme" RELATED []
is_a: GO:0097190 ! apoptotic signaling pathway

[Term]
id: GO:0008627
name: intrinsic apoptotic signaling pathway in response to osmotic stress
namespace: biological_process
def: "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to changes in intracellular ion homeostasis, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, PMID:11454444, PMID:16483738]
synonym: "induction of apoptosis by ionic changes" RELATED []
is_a: GO:0071470 ! cellular response to osmotic stress
is_a: GO:0097193 ! intrinsic apoptotic signaling pathway

[Term]
id: GO:0008628
name: hormone-mediated apoptotic signaling pathway
namespace: biological_process
def: "A series of molecular signals mediated by the detection of a hormone, and which triggers the apoptotic signaling pathway in a cell. The pathway starts with reception of a hormone signal, and ends when the execution phase of apoptosis is triggered." [GOC:bf, GOC:mtg_apoptosis]
comment: This term is placed under GO:0097190 apoptotic signaling pathway, rather than under one of its more specific children terms, to cover for the variety of apoptosis signaling mechanisms that different hormones may use.
synonym: "apoptotic signaling pathway in response to hormone" RELATED []
synonym: "induction of apoptosis by hormones" RELATED []
is_a: GO:0009755 ! hormone-mediated signaling pathway
is_a: GO:0097190 ! apoptotic signaling pathway

[Term]
id: GO:0008630
name: intrinsic apoptotic signaling pathway in response to DNA damage
namespace: biological_process
def: "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered." [GOC:go_curators, GOC:mtg_apoptosis]
synonym: "DNA damage response, signal transduction resulting in induction of apoptosis" RELATED []
is_a: GO:0006974 ! cellular response to DNA damage stimulus
is_a: GO:0097193 ! intrinsic apoptotic signaling pathway

[Term]
id: GO:0008631
name: intrinsic apoptotic signaling pathway in response to oxidative stress
namespace: biological_process
def: "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, and ends when the execution phase of apoptosis is triggered." [GOC:ai, GOC:mtg_apoptosis]
synonym: "induction of apoptosis by oxidative stress" RELATED []
synonym: "oxidative stress-induced intrinsic apoptotic signaling pathway" EXACT [GOC:bf]
is_a: GO:0097193 ! intrinsic apoptotic signaling pathway
relationship: part_of GO:0036473 ! cell death in response to oxidative stress

[Term]
id: GO:0008633
name: obsolete activation of pro-apoptotic gene products
namespace: biological_process
def: "OBSOLETE. The conversion of proteins that induce or sustain apoptosis to an active form." [GOC:mah, GOC:mtg_apoptosis]
comment: This term was made obsolete because more specific terms were created. Additionally, the meaning of the term is ambiguous (some gene products may be involved in apoptosis, or not, depending on cell type, tissue, condition).
synonym: "activation of pro-apoptotic gene products" EXACT []
synonym: "induction of pro-apoptotic gene products" RELATED []
xref: Reactome:REACT_100125 "Granzyme-B activates BID by cleavage, Mus musculus"
xref: Reactome:REACT_100369 "Activation of BAD and translocation to mitochondria, Danio rerio"
xref: Reactome:REACT_101132 "Activation of BMF and translocation to mitochondria, Taeniopygia guttata"
xref: Reactome:REACT_101251 "Activation, translocation and oligomerization of BAX, Danio rerio"
xref: Reactome:REACT_101322 "Activation of BIM and translocation to mitochondria, Canis familiaris"
xref: Reactome:REACT_101486 "Granzyme-B activates BID by cleavage, Canis familiaris"
xref: Reactome:REACT_101888 "Activation of BAD and translocation to mitochondria, Sus scrofa"
xref: Reactome:REACT_102426 "Activation and oligomerization of BAK protein, Mus musculus"
xref: Reactome:REACT_102689 "Activation of BH3-only proteins, Canis familiaris"
xref: Reactome:REACT_103613 "Activation of BIM and translocation to mitochondria, Bos taurus"
xref: Reactome:REACT_103971 "Caspase-8 is formed from procaspase-8, Sus scrofa"
xref: Reactome:REACT_104895 "Caspase-8 activates BID by cleavage, Mus musculus"
xref: Reactome:REACT_105161 "Activation, translocation and oligomerization of BAX, Canis familiaris"
xref: Reactome:REACT_105349 "tBID activates BAK protein, Mus musculus"
xref: Reactome:REACT_105646 "Activation and oligomerization of BAK protein, Taeniopygia guttata"
xref: Reactome:REACT_106071 "Activation, myristolyation of BID and translocation to mitochondria, Sus scrofa"
xref: Reactome:REACT_106739 "tBID activates BAK protein, Bos taurus"
xref: Reactome:REACT_107241 "tBID activates BAK protein, Sus scrofa"
xref: Reactome:REACT_107597 "Granzyme-B activates BID by cleavage, Sus scrofa"
xref: Reactome:REACT_108564 "Activation, myristolyation of BID and translocation to mitochondria, Taeniopygia guttata"
xref: Reactome:REACT_108722 "Activation, myristolyation of BID and translocation to mitochondria, Xenopus tropicalis"
xref: Reactome:REACT_108875 "tBID activates BAK protein, Canis familiaris"
xref: Reactome:REACT_110022 "Activation of BAD and translocation to mitochondria, Rattus norvegicus"
xref: Reactome:REACT_110545 "Activation, translocation and oligomerization of BAX, Rattus norvegicus"
xref: Reactome:REACT_110702 "Activation of BAD and translocation to mitochondria, Mus musculus"
xref: Reactome:REACT_110737 "Activation and oligomerization of BAK protein, Rattus norvegicus"
xref: Reactome:REACT_112012 "Activation of BIM and translocation to mitochondria, Xenopus tropicalis"
xref: Reactome:REACT_112277 "Granzyme-B activates BID by cleavage, Xenopus tropicalis"
xref: Reactome:REACT_112394 "Activation of NOXA and translocation to mitochondria, Canis familiaris"
xref: Reactome:REACT_112824 "Caspase-8 is formed from procaspase-8, Caenorhabditis elegans"
xref: Reactome:REACT_112867 "Activation of NOXA and translocation to mitochondria, Sus scrofa"
xref: Reactome:REACT_113401 "Activation of NOXA and translocation to mitochondria, Rattus norvegicus"
xref: Reactome:REACT_115069 "Activation of BAD and translocation to mitochondria, Xenopus tropicalis"
xref: Reactome:REACT_115317 "Activation of NOXA and translocation to mitochondria, Mus musculus"
xref: Reactome:REACT_1194 "Activation of NOXA and translocation to mitochondria, Homo sapiens"
xref: Reactome:REACT_121 "Activation of PUMA and translocation to mitochondria, Homo sapiens"
xref: Reactome:REACT_1320 "Caspase-8 activates BID by cleavage, Homo sapiens"
xref: Reactome:REACT_1424 "tBID activates BAK protein, Homo sapiens"
xref: Reactome:REACT_1503 "Caspase-8 is formed from procaspase-8, Homo sapiens"
xref: Reactome:REACT_1610 "Granzyme-B activates BID by cleavage, Homo sapiens"
xref: Reactome:REACT_1650 "Activation of BIM and translocation to mitochondria, Homo sapiens"
xref: Reactome:REACT_2100 "Activation of BMF and translocation to mitochondria, Homo sapiens"
xref: Reactome:REACT_28422 "Activation and oligomerization of BAK protein, Bos taurus"
xref: Reactome:REACT_29115 "Caspase-8 activates BID by cleavage, Canis familiaris"
xref: Reactome:REACT_30650 "Activation of BMF and translocation to mitochondria, Xenopus tropicalis"
xref: Reactome:REACT_31592 "Activation of BIM and translocation to mitochondria, Sus scrofa"
xref: Reactome:REACT_32445 "Activation of BH3-only proteins, Sus scrofa"
xref: Reactome:REACT_33117 "Activation of BH3-only proteins, Gallus gallus"
xref: Reactome:REACT_33493 "Activation of BH3-only proteins, Danio rerio"
xref: Reactome:REACT_34491 "Caspase-8 is formed from procaspase-8, Canis familiaris"
xref: Reactome:REACT_549 "Activation of BAD and translocation to mitochondria, Homo sapiens"
xref: Reactome:REACT_584 "Activation, translocation and oligomerization of BAX, Homo sapiens"
xref: Reactome:REACT_697 "Activation of BH3-only proteins, Homo sapiens"
xref: Reactome:REACT_701 "Activation, myristolyation of BID and translocation to mitochondria, Homo sapiens"
xref: Reactome:REACT_707 "Activation and oligomerization of BAK protein, Homo sapiens"
xref: Reactome:REACT_77164 "Caspase-8 is formed from procaspase-8, Taeniopygia guttata"
xref: Reactome:REACT_77838 "Activation of BMF and translocation to mitochondria, Gallus gallus"
xref: Reactome:REACT_78179 "Caspase-8 activates BID by cleavage, Rattus norvegicus"
xref: Reactome:REACT_79385 "Activation of BMF and translocation to mitochondria, Rattus norvegicus"
xref: Reactome:REACT_79715 "Activation, myristolyation of BID and translocation to mitochondria, Mus musculus"
xref: Reactome:REACT_79801 "Activation of BH3-only proteins, Taeniopygia guttata"
xref: Reactome:REACT_80000 "tBID activates BAK protein, Taeniopygia guttata"
xref: Reactome:REACT_81120 "Activation and oligomerization of BAK protein, Gallus gallus"
xref: Reactome:REACT_81817 "Caspase-8 is formed from procaspase-8, Gallus gallus"
xref: Reactome:REACT_82840 "Activation, translocation and oligomerization of BAX, Sus scrofa"
xref: Reactome:REACT_84905 "Caspase-8 activates BID by cleavage, Taeniopygia guttata"
xref: Reactome:REACT_85149 "Caspase-8 is formed from procaspase-8, Bos taurus"
xref: Reactome:REACT_85403 "Activation and oligomerization of BAK protein, Canis familiaris"
xref: Reactome:REACT_85478 "Activation, myristolyation of BID and translocation to mitochondria, Canis familiaris"
xref: Reactome:REACT_85639 "Activation, translocation and oligomerization of BAX, Xenopus tropicalis"
xref: Reactome:REACT_85678 "Activation of BMF and translocation to mitochondria, Mus musculus"
xref: Reactome:REACT_85851 "Activation and oligomerization of BAK protein, Sus scrofa"
xref: Reactome:REACT_86117 "Granzyme-B activates BID by cleavage, Rattus norvegicus"
xref: Reactome:REACT_86237 "Caspase-8 is formed from procaspase-8, Mus musculus"
xref: Reactome:REACT_87139 "Caspase-8 is formed from procaspase-8, Rattus norvegicus"
xref: Reactome:REACT_87505 "Activation, translocation and oligomerization of BAX, Bos taurus"
xref: Reactome:REACT_88929 "Caspase-8 activates BID by cleavage, Sus scrofa"
xref: Reactome:REACT_89382 "Activation of BIM and translocation to mitochondria, Mus musculus"
xref: Reactome:REACT_89481 "Activation of BMF and translocation to mitochondria, Canis familiaris"
xref: Reactome:REACT_90515 "Activation, translocation and oligomerization of BAX, Mus musculus"
xref: Reactome:REACT_91640 "Activation of BH3-only proteins, Rattus norvegicus"
xref: Reactome:REACT_91879 "Activation of BH3-only proteins, Mus musculus"
xref: Reactome:REACT_92391 "Caspase-8 is formed from procaspase-8, Danio rerio"
xref: Reactome:REACT_92522 "Activation of BMF and translocation to mitochondria, Bos taurus"
xref: Reactome:REACT_93668 "Activation of BIM and translocation to mitochondria, Rattus norvegicus"
xref: Reactome:REACT_93967 "tBID activates BAK protein, Rattus norvegicus"
xref: Reactome:REACT_94301 "Caspase-8 activates BID by cleavage, Gallus gallus"
xref: Reactome:REACT_94673 "Caspase-8 activates BID by cleavage, Bos taurus"
xref: Reactome:REACT_95412 "Activation, myristolyation of BID and translocation to mitochondria, Bos taurus"
xref: Reactome:REACT_95730 "Activation of BAD and translocation to mitochondria, Bos taurus"
xref: Reactome:REACT_97025 "Activation of BH3-only proteins, Xenopus tropicalis"
xref: Reactome:REACT_97320 "Activation, myristolyation of BID and translocation to mitochondria, Gallus gallus"
xref: Reactome:REACT_97426 "Activation of BH3-only proteins, Bos taurus"
xref: Reactome:REACT_98282 "Activation, translocation and oligomerization of BAX, Taeniopygia guttata"
xref: Reactome:REACT_98335 "Activation, myristolyation of BID and translocation to mitochondria, Rattus norvegicus"
xref: Reactome:REACT_99698 "tBID activates BAK protein, Gallus gallus"
xref: Reactome:REACT_99912 "Activation of BAD and translocation to mitochondria, Canis familiaris"
xref: Reactome:REACT_99921 "Granzyme-B activates BID by cleavage, Bos taurus"
is_obsolete: true

[Term]
id: GO:0008634
name: obsolete negative regulation of survival gene product expression
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of survival gene product expression; survival gene products are those that antagonize the apoptotic program. Regulation can be at the transcriptional, translational, or posttranslational level." [GOC:dph, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb]
comment: This term was made obsolete because the meaning of the term is ambiguous: the same gene product may or may not have a role in apoptosis depending on the cell type, tissue type, condition, etc.
synonym: "down regulation of survival gene product activity" BROAD []
synonym: "down-regulation of survival gene product activity" BROAD []
synonym: "downregulation of survival gene product activity" BROAD []
synonym: "inhibition of survival gene product activity" NARROW []
synonym: "negative regulation of survival gene product activity" BROAD [GOC:dph, GOC:tb]
synonym: "negative regulation of survival gene product expression" EXACT []
synonym: "negative regulation of survival gene products" BROAD []
is_obsolete: true

[Term]
id: GO:0008635
name: activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
namespace: biological_process
def: "Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process and is mediated by cytochrome c." [GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, Wikipedia:Caspase]
synonym: "activation of caspase activity by cytochrome c" NARROW []
synonym: "caspase activation via cytochrome c" EXACT [GOC:dph, GOC:tb]
xref: Reactome:REACT_111966 "Activation of caspases through apoptosome-mediated cleavage, Bos taurus"
xref: Reactome:REACT_113336 "Activation of caspases through apoptosome-mediated cleavage, Rattus norvegicus"
xref: Reactome:REACT_114180 "Activation of caspases through apoptosome-mediated cleavage, Canis familiaris"
xref: Reactome:REACT_114234 "Activation of caspases through apoptosome-mediated cleavage, Sus scrofa"
xref: Reactome:REACT_607 "Activation of caspases through apoptosome-mediated cleavage, Homo sapiens"
xref: Reactome:REACT_78835 "Activation of caspases through apoptosome-mediated cleavage, Danio rerio"
xref: Reactome:REACT_85020 "Activation of caspases through apoptosome-mediated cleavage, Mus musculus"
xref: Reactome:REACT_89617 "Activation of caspases through apoptosome-mediated cleavage, Gallus gallus"
xref: Reactome:REACT_92396 "Activation of caspases through apoptosome-mediated cleavage, Xenopus tropicalis"
xref: Reactome:REACT_95235 "Activation of caspases through apoptosome-mediated cleavage, Taeniopygia guttata"
is_a: GO:0006919 ! activation of cysteine-type endopeptidase activity involved in apoptotic process

[Term]
id: GO:0008636
name: obsolete activation of caspase activity by protein phosphorylation
namespace: biological_process
def: "OBSOLETE. Upregulation of the activity of a caspase, any of a group of cysteine proteases involved in apoptosis, by the addition of a phosphate group." [GOC:dph, GOC:jl, GOC:tb, PMID:14744432, Wikipedia:Caspase]
comment: This term was made obsolete because it is ill-defined: phosphorylation regulates the activity of caspases, but it doesn't activate them (caspases are only activated upon cleavage).
synonym: "activation of caspase activity by protein amino acid phosphorylation" EXACT [GOC:bf]
synonym: "activation of caspase activity by protein phosphorylation" EXACT []
synonym: "caspase activation via phosphorylation" EXACT [GOC:dph, GOC:tb]
is_obsolete: true

[Term]
id: GO:0008637
name: apoptotic mitochondrial changes
namespace: biological_process
def: "The morphological and physiological alterations undergone by mitochondria during apoptosis." [GOC:mah, GOC:mtg_apoptosis]
comment: This term was created to reflect the fundamental role of the mitochondrial compartment in apoptosis. Most processes under this node occur during the signaling phase of apoptosis, but e.g. GO:0043653 'mitochondrial fragmentation involved in apoptotic process' cannot be confidently placed under the signaling phase. For this reason, the parent term GO:0008637 'apoptotic mitochondrial changes' is not linked to the signaling or execution phase specifically, but its descendants are when current knowledge allows for it.
is_a: GO:0007005 ! mitochondrion organization
relationship: part_of GO:0006915 ! apoptotic process

[Term]
id: GO:0008638
name: obsolete protein tagging activity
namespace: molecular_function
def: "OBSOLETE. Covalent addition of a specific tagging molecule to a protein, targeting the tagged protein for some fate e.g. degradation." [GOC:jl]
comment: This term was made obsolete because it represents a biological process and a molecular function.
synonym: "protein tagging activity" EXACT []
is_obsolete: true
consider: GO:0005515
consider: GO:0006464
consider: GO:0031386

[Term]
id: GO:0008641
name: small protein activating enzyme activity
namespace: molecular_function
alt_id: GO:0008642
def: "Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:jl, GOC:mah]
subset: goslim_pir
synonym: "ubiquitin-like activating enzyme activity" NARROW []
is_a: GO:0016877 ! ligase activity, forming carbon-sulfur bonds

[Term]
id: GO:0008643
name: carbohydrate transport
namespace: biological_process
alt_id: GO:0006861
alt_id: GO:0008644
def: "The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
synonym: "sugar transport" NARROW []
is_a: GO:0044765 ! single-organism transport
is_a: GO:0071702 ! organic substance transport

[Term]
id: GO:0008645
name: hexose transport
namespace: biological_process
def: "The directed movement of hexose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Hexoses are any aldoses with a chain of six carbon atoms in the molecule." [GOC:ai]
subset: gosubset_prok
xref: Reactome:REACT_100058 "Hexose transport, Canis familiaris"
xref: Reactome:REACT_104970 "Hexose transport, Caenorhabditis elegans"
xref: Reactome:REACT_110377 "Hexose transport, Saccharomyces cerevisiae"
xref: Reactome:REACT_112026 "Hexose transport, Dictyostelium discoideum"
xref: Reactome:REACT_112310 "Hexose transport, Mycobacterium tuberculosis"
xref: Reactome:REACT_32187 "Hexose transport, Danio rerio"
xref: Reactome:REACT_33190 "Hexose transport, Arabidopsis thaliana"
xref: Reactome:REACT_77183 "Hexose transport, Mus musculus"
xref: Reactome:REACT_77191 "Hexose transport, Sus scrofa"
xref: Reactome:REACT_85468 "Hexose transport, Escherichia coli"
xref: Reactome:REACT_85632 "Hexose transport, Oryza sativa"
xref: Reactome:REACT_9441 "Hexose transport, Homo sapiens"
xref: Reactome:REACT_94923 "Hexose transport, Plasmodium falciparum"
xref: Reactome:REACT_96504 "Hexose transport, Xenopus tropicalis"
xref: Reactome:REACT_96740 "Hexose transport, Drosophila melanogaster"
xref: Reactome:REACT_97695 "Hexose transport, Gallus gallus"
xref: Reactome:REACT_97768 "Hexose transport, Bos taurus"
xref: Reactome:REACT_98325 "Hexose transport, Taeniopygia guttata"
xref: Reactome:REACT_98343 "Hexose transport, Schizosaccharomyces pombe"
xref: Reactome:REACT_99675 "Hexose transport, Rattus norvegicus"
is_a: GO:0015749 ! monosaccharide transport

[Term]
id: GO:0008646
name: high-affinity hexose transport
namespace: biological_process
def: "The directed, high-affinity movement of a hexose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mah]
is_a: GO:0035428 ! hexose transmembrane transport

[Term]
id: GO:0008647
name: low-affinity hexose transport
namespace: biological_process
def: "The directed, low-affinity movement of a hexose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. In low-affinity transport the transporter is able to bind the solute only if it is only present at very low concentrations." [GOC:mah]
is_a: GO:0035428 ! hexose transmembrane transport

[Term]
id: GO:0008648
name: obsolete tachykinin
namespace: molecular_function
def: "OBSOLETE. A family of hormones that stimulate secretion of saliva and cause smooth muscle contraction and vasodilation." [ISBN:0198506732, ISBN:0721662544]
comment: This term was made obsolete because it represents a gene product.
synonym: "tachykinin" EXACT []
is_obsolete: true
consider: GO:0005102
consider: GO:0045909
consider: GO:0045987
consider: GO:0046878

[Term]
id: GO:0008649
name: rRNA methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule." [GOC:mah]
subset: gosubset_prok
xref: EC:2.1.1.-
is_a: GO:0008173 ! RNA methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
relationship: part_of GO:0031167 ! rRNA methylation

[Term]
id: GO:0008650
name: rRNA (uridine-2'-O-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methyluridine." [GOC:mah]
subset: gosubset_prok
xref: EC:2.1.1.-
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0016436 ! rRNA (uridine) methyltransferase activity

[Term]
id: GO:0008651
name: obsolete actin polymerizing activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a biological process.
synonym: "actin polymerizing activity" EXACT []
is_obsolete: true
consider: GO:0030041
consider: GO:0042802

[Term]
id: GO:0008652
name: cellular amino acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents." [ISBN:0198506732]
subset: gosubset_prok
synonym: "amino acid biosynthetic process" EXACT [GOC:curators]
synonym: "cellular amino acid anabolism" EXACT []
synonym: "cellular amino acid biosynthesis" EXACT []
synonym: "cellular amino acid formation" EXACT []
synonym: "cellular amino acid synthesis" EXACT []
xref: Reactome:REACT_101745 "Amino acid synthesis and interconversion (transamination), Saccharomyces cerevisiae"
xref: Reactome:REACT_106399 "Amino acid synthesis and interconversion (transamination), Schizosaccharomyces pombe"
xref: Reactome:REACT_108419 "Amino acid synthesis and interconversion (transamination), Bos taurus"
xref: Reactome:REACT_109330 "Amino acid synthesis and interconversion (transamination), Drosophila melanogaster"
xref: Reactome:REACT_110509 "Amino acid synthesis and interconversion (transamination), Oryza sativa"
xref: Reactome:REACT_112051 "Amino acid synthesis and interconversion (transamination), Staphylococcus aureus N315"
xref: Reactome:REACT_238 "Amino acid synthesis and interconversion (transamination), Homo sapiens"
xref: Reactome:REACT_30236 "Amino acid synthesis and interconversion (transamination), Rattus norvegicus"
xref: Reactome:REACT_30845 "Amino acid synthesis and interconversion (transamination), Arabidopsis thaliana"
xref: Reactome:REACT_31295 "Amino acid synthesis and interconversion (transamination), Sus scrofa"
xref: Reactome:REACT_33022 "Amino acid synthesis and interconversion (transamination), Caenorhabditis elegans"
xref: Reactome:REACT_77237 "Amino acid synthesis and interconversion (transamination), Dictyostelium discoideum"
xref: Reactome:REACT_77379 "Amino acid synthesis and interconversion (transamination), Mus musculus"
xref: Reactome:REACT_77480 "Amino acid synthesis and interconversion (transamination), Canis familiaris"
xref: Reactome:REACT_77498 "Amino acid synthesis and interconversion (transamination), Plasmodium falciparum"
xref: Reactome:REACT_79609 "Amino acid synthesis and interconversion (transamination), Escherichia coli"
xref: Reactome:REACT_83815 "Amino acid synthesis and interconversion (transamination), Danio rerio"
xref: Reactome:REACT_83995 "Amino acid synthesis and interconversion (transamination), Gallus gallus"
xref: Reactome:REACT_89765 "Amino acid synthesis and interconversion (transamination), Xenopus tropicalis"
xref: Reactome:REACT_92648 "Amino acid synthesis and interconversion (transamination), Mycobacterium tuberculosis"
xref: Reactome:REACT_95114 "Amino acid synthesis and interconversion (transamination), Taeniopygia guttata"
xref: Wikipedia:Amino_acid_synthesis
is_a: GO:0006520 ! cellular amino acid metabolic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process

[Term]
id: GO:0008653
name: lipopolysaccharide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide." [ISBN:0198506732]
subset: gosubset_prok
synonym: "lipopolysaccharide metabolism" EXACT []
synonym: "LPS metabolic process" EXACT []
is_a: GO:0044255 ! cellular lipid metabolic process
is_a: GO:0044264 ! cellular polysaccharide metabolic process
is_a: GO:0044723 ! single-organism carbohydrate metabolic process
is_a: GO:1903509 ! liposaccharide metabolic process

[Term]
id: GO:0008654
name: phospholipid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]
subset: gosubset_prok
synonym: "phospholipid anabolism" EXACT []
synonym: "phospholipid biosynthesis" EXACT []
synonym: "phospholipid formation" EXACT []
synonym: "phospholipid synthesis" EXACT []
xref: MetaCyc:LIPASYN-PWY
xref: MetaCyc:PHOSLIPSYN-PWY
xref: MetaCyc:PHOSLIPSYN2-PWY
is_a: GO:0006644 ! phospholipid metabolic process
is_a: GO:0008610 ! lipid biosynthetic process
is_a: GO:0044249 ! cellular biosynthetic process
is_a: GO:0090407 ! organophosphate biosynthetic process

[Term]
id: GO:0008655
name: pyrimidine-containing compound salvage
namespace: biological_process
def: "Any process that generates a pyrimidine-containing compound, any nucleobase, nucleoside, nucleotide or nucleic acid that contains a pyrimidine base, from derivatives of them without de novo synthesis." [CHEBI:39447, GOC:jl]
subset: goslim_pir
subset: gosubset_prok
synonym: "pyrimidine salvage" RELATED [GOC:curators]
is_a: GO:0034654 ! nucleobase-containing compound biosynthetic process
is_a: GO:0043094 ! cellular metabolic compound salvage
is_a: GO:0072528 ! pyrimidine-containing compound biosynthetic process

[Term]
id: GO:0008656
name: cysteine-type endopeptidase activator activity involved in apoptotic process
namespace: molecular_function
def: "Increases the rate of proteolysis catalyzed by a cysteine-type endopeptidase involved in the apoptotic process." [GOC:mah, GOC:mtg_apoptosis]
comment: Examples of this are 1) granzymes that may bind to initiator caspases and cleave them, and 2) already active caspases, e.g. caspase 9, that cleave effector caspases.
synonym: "caspase activator activity" BROAD []
xref: Reactome:REACT_23804 "Interleukin-1 family precursors are cleaved by caspase-1, Homo sapiens"
is_a: GO:0016505 ! peptidase activator activity involved in apoptotic process
is_a: GO:0043028 ! cysteine-type endopeptidase regulator activity involved in apoptotic process
relationship: part_of GO:0006919 ! activation of cysteine-type endopeptidase activity involved in apoptotic process

[Term]
id: GO:0008657
name: DNA topoisomerase (ATP-hydrolyzing) inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2." [GOC:mah]
synonym: "DNA gyrase inhibitor activity" EXACT [GOC:dph, GOC:tb]
is_a: GO:0042030 ! ATPase inhibitor activity
is_a: GO:0072586 ! DNA topoisomerase (ATP-hydrolyzing) regulator activity
relationship: negatively_regulates GO:0003918 ! DNA topoisomerase type II (ATP-hydrolyzing) activity
relationship: part_of GO:2000372 ! negative regulation of DNA topoisomerase (ATP-hydrolyzing) activity

[Term]
id: GO:0008658
name: penicillin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with penicillin, any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008144 ! drug binding
is_a: GO:0033218 ! amide binding
is_a: GO:0033293 ! monocarboxylic acid binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding
is_a: GO:1901681 ! sulfur compound binding

[Term]
id: GO:0008659
name: (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3R)-3-hydroxytetradecanoyl-[acyl-carrier protein] = tetradecenoyl-[acyl-carrier protein] + H2O." [EC:4.2.1.-, GOC:ai]
synonym: "(3R)-hydroxymyristoyl-[acyl-carrier protein] dehydratase activity" EXACT []
synonym: "(3R)-hydroxymyristoyl-ACP dehydratase activity" EXACT []
xref: EC:4.2.1.-
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0008660
name: 1-aminocyclopropane-1-carboxylate deaminase activity
namespace: molecular_function
alt_id: GO:0018806
def: "Catalysis of the reaction: 1-aminocyclopropane-1-carboxylate + H(2)O = 2-oxobutanate + NH(4)(+)." [EC:3.5.99.7, RHEA:16936]
comment: Note that this function was formerly EC:4.1.99.4.
subset: gosubset_prok
synonym: "1-aminocyclopropane carboxylic acid deaminase activity" EXACT [EC:3.5.99.7]
synonym: "1-aminocyclopropane-1-carboxylate aminohydrolase (isomerizing)" EXACT [EC:3.5.99.7]
synonym: "1-aminocyclopropane-1-carboxylate endolyase (deaminating) activity" EXACT [EC:3.5.99.7]
synonym: "ACC deaminase activity" EXACT [EC:3.5.99.7]
xref: EC:3.5.99.7
xref: KEGG:R00997
xref: MetaCyc:4.1.99.4-RXN
xref: RHEA:16936
xref: UM-BBD_reactionID:r0357
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0008661
name: 1-deoxy-D-xylulose-5-phosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO(2)." [EC:2.2.1.7, RHEA:12608]
subset: gosubset_prok
synonym: "1-deoxy-D-xylulose-5-phosphate pyruvate-lyase (carboxylating) activity" EXACT []
synonym: "1-deoxyxylulose-5-phosphate synthase activity" EXACT []
synonym: "DOXP synthase activity" EXACT []
synonym: "DXP-synthase activity" EXACT []
synonym: "pyruvate:D-glyceraldehyde-3-phosphate acetaldehydetransferase (decarboxylating)" EXACT [EC:2.2.1.7]
xref: EC:2.2.1.7
xref: KEGG:R05636
xref: MetaCyc:DXS-RXN
xref: RHEA:12608
is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups

[Term]
id: GO:0008662
name: 1-phosphofructokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-fructose 1-phosphate = ADP + D-fructose 1,6-bisphosphate." [EC:2.7.1.56]
subset: gosubset_prok
synonym: "1-phosphofructokinase (phosphorylating)" EXACT [EC:2.7.1.56]
synonym: "ATP:D-fructose-phosphate 6-phosphotransferase activity" EXACT [EC:2.7.1.56]
synonym: "D-fructose-1-phosphate kinase activity" EXACT [EC:2.7.1.56]
synonym: "fructose 1-phosphate kinase activity" EXACT [EC:2.7.1.56]
synonym: "fructose-1-phosphate kinase activity" EXACT [EC:2.7.1.56]
synonym: "phosphofructokinase 1" RELATED [EC:2.7.1.56]
xref: EC:2.7.1.56
xref: MetaCyc:1PFRUCTPHOSN-RXN
xref: RHEA:14216
is_a: GO:0008443 ! phosphofructokinase activity

[Term]
id: GO:0008663
name: 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 3'-phosphate." [EC:3.1.4.16]
subset: gosubset_prok
synonym: "2',3 '-cyclic AMP phosphodiesterase activity" EXACT [EC:3.1.4.16]
synonym: "2',3'-cyclic AMP 2'-phosphohydrolase activity" EXACT [EC:3.1.4.16]
synonym: "2',3'-cyclic nucleoside monophosphate phosphodiesterase" BROAD [EC:3.1.4.16]
synonym: "2',3'-cyclic nucleotidase activity" EXACT [EC:3.1.4.16]
synonym: "2',3'-cyclic nucleotide phosphohydrolase" BROAD [EC:3.1.4.16]
synonym: "2':3'-cyclic nucleotide phosphodiesterase:3'-nucleotidase activity" EXACT [EC:3.1.4.16]
synonym: "2':3'-cyclic phosphodiesterase activity" EXACT [EC:3.1.4.16]
synonym: "cyclic 2',3'-nucleotide 2'-phosphodiesterase activity" EXACT [EC:3.1.4.16]
synonym: "cyclic 2',3'-nucleotide phosphodiesterase" BROAD [EC:3.1.4.16]
synonym: "cyclic phosphodiesterase:3'-nucleotidase activity" EXACT [EC:3.1.4.16]
synonym: "nucleoside-2',3'-cyclic-phosphate 3'-nucleotidohydrolase activity" EXACT [EC:3.1.4.16]
synonym: "ribonucleoside 2',3'-cyclic phosphate diesterase activity" EXACT [EC:3.1.4.16]
xref: EC:3.1.4.16
xref: MetaCyc:CYCPHOSDIESTER-RXN
is_a: GO:0004112 ! cyclic-nucleotide phosphodiesterase activity

[Term]
id: GO:0008664
name: 2'-5'-RNA ligase activity
namespace: molecular_function
def: "Catalysis of the formation of a phosphodiester bond between the 2'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another." [GOC:mah, PMID:8940112]
subset: gosubset_prok
synonym: "2'-5' RNA ligase activity" EXACT []
xref: EC:6.5.1.-
is_a: GO:0008452 ! RNA ligase activity

[Term]
id: GO:0008665
name: 2'-phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a phosphate group from one compound to the 2' position of another." [GOC:jl, GOC:mah]
subset: gosubset_prok
xref: MetaCyc:2.7.1.160-RXN
is_a: GO:0016740 ! transferase activity

[Term]
id: GO:0008666
name: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-2,3,4,5-tetrahydrodipicolinate + H(2)O + succinyl-CoA = L-2-succinylamino-6-oxopimelate + CoA." [EC:2.3.1.117, RHEA:17328]
subset: gosubset_prok
synonym: "succinyl-CoA:(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity" EXACT [EC:2.3.1.117]
synonym: "succinyl-CoA:2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity" EXACT [EC:2.3.1.117]
synonym: "succinyl-CoA:tetrahydrodipicolinate N-succinyltransferase activity" EXACT [EC:2.3.1.117]
synonym: "tetrahydrodipicolinate N-succinyltransferase activity" EXACT [EC:2.3.1.117]
synonym: "tetrahydrodipicolinate succinylase activity" EXACT [EC:2.3.1.117]
synonym: "tetrahydrodipicolinate succinyltransferase activity" EXACT [EC:2.3.1.117]
synonym: "tetrahydropicolinate succinylase activity" EXACT [EC:2.3.1.117]
synonym: "THDP N-succinyltransferase activity" EXACT [PMID:19394346]
xref: EC:2.3.1.117
xref: KEGG:R04365
xref: MetaCyc:TETHYDPICSUCC-RXN
xref: RHEA:17328
is_a: GO:0016749 ! N-succinyltransferase activity

[Term]
id: GO:0008667
name: 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD(+) = 2,3-dihydroxybenzoate + H(+) + NADH." [EC:1.3.1.28, RHEA:23827]
subset: gosubset_prok
synonym: "2,3-DHB dehydrogenase activity" EXACT [EC:1.3.1.28]
synonym: "2,3-dihydro-2,3-dihydroxybenzoate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.28]
xref: EC:1.3.1.28
xref: KEGG:R01505
xref: MetaCyc:DHBDEHYD-RXN
xref: RHEA:23827
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008668
name: (2,3-dihydroxybenzoyl)adenylate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-dihydroxybenzoate + ATP = 2,3-dihydroxybenzoyl 5'-adenylate + diphosphate." [EC:2.7.7.58, RHEA:20232]
subset: gosubset_prok
synonym: "2,3-dihydroxybenzoate-AMP ligase activity" EXACT []
synonym: "ATP:2,3-dihydroxybenzoate adenylyltransferase activity" EXACT [EC:2.7.7.58]
xref: EC:2.7.7.58
xref: KEGG:R01504
xref: MetaCyc:DHBAMPLIG-RXN
xref: RHEA:20232
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0008670
name: 2,4-dienoyl-CoA reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-2,3-didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH + H+." [EC:1.3.1.34]
subset: gosubset_prok
synonym: "4-enoyl coenzyme A (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.3.1.34]
synonym: "4-enoyl-CoA reductase (NADPH) activity" EXACT [EC:1.3.1.34]
synonym: "4-enoyl-CoA reductase (NADPH2)" EXACT [EC:1.3.1.34]
synonym: "4-enoyl-CoA reductase activity" EXACT [EC:1.3.1.34]
synonym: "trans-2,3-didehydroacyl-CoA:NADP+ 4-oxidoreductase activity" EXACT [EC:1.3.1.34]
xref: EC:1.3.1.34
xref: MetaCyc:DIENOYLCOAREDUCT-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008671
name: 2-dehydro-3-deoxygalactonokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-dehydro-3-deoxy-D-galactonate + ATP = 6-phospho-2-dehydro-3-deoxy-D-galactonate + ADP + 2 H(+)." [EC:2.7.1.58, RHEA:16528]
subset: gosubset_prok
synonym: "2-keto-3-deoxy-galactonokinase activity" EXACT [EC:2.7.1.58]
synonym: "2-keto-3-deoxygalactonate kinase (phosphorylating)" EXACT [EC:2.7.1.58]
synonym: "2-keto-3-deoxygalactonokinase activity" EXACT [EC:2.7.1.58]
synonym: "2-oxo-3-deoxygalactonate kinase activity" EXACT [EC:2.7.1.58]
synonym: "ATP:2-dehydro-3-deoxy-D-galactonate 6-phosphotransferase activity" EXACT [EC:2.7.1.58]
xref: EC:2.7.1.58
xref: KEGG:R03387
xref: MetaCyc:DEHYDDEOXGALACTKIN-RXN
xref: RHEA:16528
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0008672
name: 2-dehydro-3-deoxyglucarate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-dehydro-3-deoxy-D-glucarate = pyruvate + tartronate semialdehyde." [EC:4.1.2.20]
subset: gosubset_prok
synonym: "2-dehydro-3-deoxy-D-glucarate tartronate-semialdehyde-lyase (pyruvate-forming)" EXACT [EC:4.1.2.20]
synonym: "2-dehydro-3-deoxy-D-glucarate tartronate-semialdehyde-lyase activity" EXACT [EC:4.1.2.20]
synonym: "2-keto-3-deoxyglucarate aldolase activity" EXACT [EC:4.1.2.20]
synonym: "alpha-keto-beta-deoxy-D-glucarate aldolase activity" EXACT [EC:4.1.2.20]
xref: EC:4.1.2.20
xref: MetaCyc:KDGALDOL-RXN
xref: RHEA:10271
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0008673
name: 2-dehydro-3-deoxygluconokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate + ATP = 2-dehydro-3-deoxy-6-phospho-D-gluconate + ADP + 2 H(+)." [EC:2.7.1.45, RHEA:14800]
subset: gosubset_prok
synonym: "2-keto-3-deoxy-D-gluconic acid kinase activity" EXACT [EC:2.7.1.45]
synonym: "2-keto-3-deoxygluconate kinase activity" EXACT [EC:2.7.1.45]
synonym: "2-keto-3-deoxygluconokinase (phosphorylating)" EXACT [EC:2.7.1.45]
synonym: "2-keto-3-deoxygluconokinase activity" EXACT [EC:2.7.1.45]
synonym: "3-deoxy-2-oxo-D-gluconate kinase activity" EXACT [EC:2.7.1.45]
synonym: "ATP:2-dehydro-3-deoxy-D-gluconate 6-phosphotransferase activity" EXACT [EC:2.7.1.45]
synonym: "KDG kinase activity" EXACT [EC:2.7.1.45]
synonym: "ketodeoxygluconokinase activity" EXACT [EC:2.7.1.45]
xref: EC:2.7.1.45
xref: KEGG:R01541
xref: MetaCyc:DEOXYGLUCONOKIN-RXN
xref: RHEA:14800
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0008674
name: 2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-phospho-2-dehydro-3-deoxy-D-galactonate = D-glyceraldehyde 3-phosphate + pyruvate." [EC:4.1.2.21, RHEA:24467]
subset: gosubset_prok
synonym: "(KDPGal)aldolase activity" EXACT [EC:4.1.2.21]
synonym: "2-dehydro-3-deoxy-D-galactonate-6-phosphate D-glyceraldehyde-3-phosphate-lyase (pyruvate-forming)" EXACT [EC:4.1.2.21]
synonym: "2-dehydro-3-deoxy-D-galactonate-6-phosphate D-glyceraldehyde-3-phosphate-lyase activity" EXACT [EC:4.1.2.21]
synonym: "2-dehydro-3-deoxyphosphogalactonate aldolase activity" EXACT []
synonym: "2-keto-3-deoxy-6-phosphogalactonic acid aldolase activity" EXACT [EC:4.1.2.21]
synonym: "2-keto-3-deoxy-6-phosphogalactonic aldolase activity" EXACT [EC:4.1.2.21]
synonym: "2-oxo-3-deoxygalactonate 6-phosphate aldolase activity" EXACT [EC:4.1.2.21]
synonym: "6-phospho-2-dehydro-3-deoxygalactonate aldolase activity" EXACT [EC:4.1.2.21]
synonym: "6-phospho-2-keto-3-deoxygalactonate aldolase activity" EXACT [EC:4.1.2.21]
synonym: "phospho-2-keto-3-deoxygalactonate aldolase activity" EXACT [EC:4.1.2.21]
synonym: "phospho-2-keto-3-deoxygalactonic aldolase activity" EXACT [EC:4.1.2.21]
xref: EC:4.1.2.21
xref: KEGG:R01064
xref: MetaCyc:DEHYDDEOXPHOSGALACT-ALDOL-RXN
xref: RHEA:24467
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0008675
name: 2-dehydro-3-deoxy-phosphogluconate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate 6-phosphate = pyruvate + D-glyceraldehyde 3-phosphate." [EC:4.1.2.14]
subset: gosubset_prok
synonym: "2-dehydro-3-deoxy-D-gluconate-6-phosphate D-glyceraldehyde-3-phosphate-lyase (pyruvate-forming)" EXACT [EC:4.1.2.14]
synonym: "2-dehydro-3-deoxy-D-gluconate-6-phosphate D-glyceraldehyde-3-phosphate-lyase activity" EXACT [EC:4.1.2.14]
synonym: "2-keto-3-deoxy-6-phosphogluconate aldolase activity" EXACT [EC:4.1.2.14]
synonym: "2-keto-3-deoxy-6-phosphogluconic aldolase activity" EXACT [EC:4.1.2.14]
synonym: "2-keto-3-deoxygluconate-6-P-aldolase activity" EXACT [EC:4.1.2.14]
synonym: "2-keto-3-deoxygluconate-6-phosphate aldolase activity" EXACT [EC:4.1.2.14]
synonym: "2-oxo-3-deoxy-6-phosphogluconate aldolase activity" EXACT [EC:4.1.2.14]
synonym: "6-phospho-2-keto-3-deoxygluconate aldolase activity" EXACT [EC:4.1.2.14]
synonym: "KDPG aldolase activity" EXACT [EC:4.1.2.14]
synonym: "KDPG-aldolase activity" EXACT [EC:4.1.2.14]
synonym: "ODPG aldolase activity" EXACT [EC:4.1.2.14]
synonym: "phospho-2-dehydro-3-deoxygluconate aldolase activity" EXACT [EC:4.1.2.14]
synonym: "phospho-2-keto-3-deoxygluconate aldolase activity" EXACT [EC:4.1.2.14]
synonym: "phospho-2-keto-3-deoxygluconic aldolase activity" EXACT [EC:4.1.2.14]
xref: EC:4.1.2.14
xref: MetaCyc:KDPGALDOL-RXN
xref: RHEA:17092
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0008676
name: 3-deoxy-8-phosphooctulonate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-arabinose 5-phosphate + H(2)O + phosphoenolpyruvate = 8-phospho-3-deoxy-D-manno-oct-2-ulosonate + 2 H(+) + phosphate." [EC:2.5.1.55, RHEA:14056]
comment: Note that this function was formerly EC:4.1.2.16.
subset: gosubset_prok
synonym: "2-dehydro-3-deoxy-D-octonate-8-phosphate D-arabinose-5-phosphate-lyase (pyruvate-phosphorylating) activity" EXACT [EC:2.5.1.55]
synonym: "2-dehydro-3-deoxy-phosphooctonate aldolase activity" EXACT [EC:2.5.1.55]
synonym: "2-dehydro-3-deoxyphosphooctonate aldolase activity" EXACT []
synonym: "2-keto-3-deoxy-8-phosphooctonic synthetase activity" EXACT [EC:2.5.1.55]
synonym: "3-deoxy-D-manno-octulosonate-8-phosphate synthase activity" EXACT [EC:2.5.1.55]
synonym: "3-deoxy-D-manno-octulosonic acid 8-phosphate synthetase activity" EXACT [EC:2.5.1.55]
synonym: "3-deoxy-D-mannooctulosonate-8-phosphate synthetase activity" EXACT [EC:2.5.1.55]
synonym: "3-deoxyoctulosonic 8-phosphate synthetase activity" EXACT [EC:2.5.1.55]
synonym: "KDO-8-P synthase activity" EXACT [EC:2.5.1.55]
synonym: "KDO-8-phosphate synthetase activity" EXACT [EC:2.5.1.55]
synonym: "KDOP synthase activity" EXACT [EC:2.5.1.55]
synonym: "phospho-2-keto-3-deoxyoctonate aldolase activity" EXACT [EC:2.5.1.55]
synonym: "phosphoenolpyruvate:D-arabinose-5-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)" EXACT [EC:2.5.1.55]
xref: EC:2.5.1.55
xref: KEGG:R03254
xref: MetaCyc:KDO-8PSYNTH-RXN
xref: RHEA:14056
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0008677
name: 2-dehydropantoate 2-reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH." [EC:1.1.1.169, RHEA:16236]
subset: gosubset_prok
synonym: "(R)-pantoate:NADP+ 2-oxidoreductase activity" EXACT [EC:1.1.1.169]
synonym: "2-ketopantoate reductase activity" EXACT [EC:1.1.1.169]
synonym: "2-ketopantoic acid reductase activity" EXACT [EC:1.1.1.169]
synonym: "2-oxopantoate reductase activity" EXACT [EC:1.1.1.169]
synonym: "ketopantoate reductase activity" EXACT [EC:1.1.1.169]
synonym: "ketopantoic acid reductase activity" EXACT [EC:1.1.1.169]
synonym: "KPA reductase activity" EXACT [EC:1.1.1.169]
xref: EC:1.1.1.169
xref: KEGG:R02472
xref: MetaCyc:2-DEHYDROPANTOATE-REDUCT-RXN
xref: RHEA:16236
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008678
name: 2-deoxy-D-gluconate 3-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-deoxy-D-gluconate + NAD+ = 3-dehydro-2-deoxy-D-gluconate + NADH + H+." [EC:1.1.1.125]
subset: gosubset_prok
synonym: "2-deoxy-D-gluconate:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.125]
synonym: "2-deoxygluconate dehydrogenase activity" EXACT [EC:1.1.1.125]
synonym: "2-keto-3-deoxygluconate oxidoreductase activity" EXACT [EC:1.1.1.125]
xref: EC:1.1.1.125
xref: MetaCyc:KDUD-RXN
xref: RHEA:12163
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008679
name: 2-hydroxy-3-oxopropionate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-glycerate + NADP+ = 2-hydroxy-3-oxopropanoate + NADPH + H+." [EC:1.1.1.60]
subset: gosubset_prok
synonym: "(R)-glycerate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.60]
synonym: "tartronate semialdehyde reductase activity" EXACT [EC:1.1.1.60]
xref: EC:1.1.1.60
xref: MetaCyc:TSA-REDUCT-RXN
xref: RHEA:18844
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008681
name: 2-octaprenyl-6-methoxyphenol hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-octaprenyl-6-methoxyphenol + O2 + 4 H+ = 2-octaprenyl-6-methoxy-1,4-benzoquinol + H2O." [MetaCyc:2-OCTAPRENYL-6-METHOXYPHENOL-HYDROX-RXN]
subset: gosubset_prok
xref: EC:1.14.14.-
xref: MetaCyc:2-OCTAPRENYL-6-METHOXYPHENOL-HYDROX-RXN
xref: RHEA:29410
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0008682
name: 2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone + O2 = 2-octoprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone." [MetaCyc:OCTAPRENYL-METHYL-METHOXY-BENZOQ-OH-RXN]
synonym: "demethoxy-ubiquinone hydroxylase" RELATED [GOC:vw]
synonym: "demethoxyubiquinone monooxygenase" RELATED [GOC:vw]
xref: MetaCyc:OCTAPRENYL-METHYL-METHOXY-BENZOQ-OH-RXN
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0008683
name: 2-oxoglutarate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + H(+) = CO(2) + succinate semialdehyde." [EC:4.1.1.71, RHEA:10527]
subset: gosubset_prok
synonym: "2-oxoglutarate carboxy-lyase (succinate-semialdehyde-forming)" EXACT [EC:4.1.1.71]
synonym: "2-oxoglutarate carboxy-lyase activity" EXACT [EC:4.1.1.71]
synonym: "alpha-ketoglutarate decarboxylase activity" EXACT [EC:4.1.1.71]
synonym: "alpha-ketoglutaric decarboxylase activity" EXACT [EC:4.1.1.71]
synonym: "pre-2-oxoglutarate decarboxylase activity" EXACT [EC:4.1.1.71]
xref: EC:4.1.1.71
xref: KEGG:R00272
xref: MetaCyc:RXN-7774
xref: RHEA:10527
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0008684
name: 2-oxopent-4-enoate hydratase activity
namespace: molecular_function
alt_id: GO:0018821
def: "Catalysis of the reaction: 4-hydroxy-2-oxopentanoate = 2-oxopent-4-enoate + H2O." [EC:4.2.1.80]
subset: gosubset_prok
synonym: "2-keto-4-pentenoate (vinylpyruvate)hydratase activity" EXACT [EC:4.2.1.80]
synonym: "2-keto-4-pentenoate hydratase activity" EXACT [EC:4.2.1.80]
synonym: "4-hydroxy-2-oxopentanoate hydro-lyase (2-oxopent-4-enoate-forming)" EXACT [EC:4.2.1.80]
synonym: "4-hydroxy-2-oxopentanoate hydro-lyase activity" EXACT [EC:4.2.1.80]
synonym: "OEH activity" EXACT [EC:4.2.1.80]
xref: EC:4.2.1.80
xref: MetaCyc:2-OXOPENT-4-ENOATE-HYDRATASE-RXN
xref: RHEA:22583
xref: UM-BBD_enzymeID:e0078
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0008685
name: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP." [EC:4.6.1.12, RHEA:23867]
subset: gosubset_prok
synonym: "2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol CMP-lyase (cyclizing)" EXACT [EC:4.6.1.12]
synonym: "2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol CMP-lyase (cyclizing; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate-forming)" EXACT [EC:4.6.1.12]
synonym: "MECDP-synthase activity" EXACT [EC:4.6.1.12]
synonym: "MECP synthase activity" EXACT []
xref: EC:4.6.1.12
xref: KEGG:R05637
xref: MetaCyc:RXN0-302
xref: RHEA:23867
is_a: GO:0016849 ! phosphorus-oxygen lyase activity

[Term]
id: GO:0008686
name: 3,4-dihydroxy-2-butanone-4-phosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)." [EC:4.1.99.12, RHEA:18460]
subset: gosubset_prok
xref: EC:4.1.99.12
xref: KEGG:R07281
xref: MetaCyc:DIOHBUTANONEPSYN-RXN
xref: RHEA:18460
is_a: GO:0016830 ! carbon-carbon lyase activity

[Term]
id: GO:0008687
name: 3,4-dihydroxyphenylacetate 2,3-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,4-dihydroxyphenylacetate + O(2) = 5-formyl-2-hydroxyhepta-2,4-dienedioate + H(+)." [EC:1.13.11.15, RHEA:15636]
subset: gosubset_prok
synonym: "3,4-dihydroxyphenylacetate:oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.15]
synonym: "3,4-dihydroxyphenylacetic acid 2,3-dioxygenase activity" EXACT [EC:1.13.11.15]
synonym: "homoprotocatechuate 2,3-dioxygenase activity" EXACT [EC:1.13.11.15]
synonym: "HPC dioxygenase activity" EXACT [EC:1.13.11.15]
xref: EC:1.13.11.15
xref: KEGG:R03303
xref: MetaCyc:1.13.11.15-RXN
xref: RHEA:15636
xref: UM-BBD_reactionID:r0364
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0008688
name: 3-(3-hydroxyphenyl)propionate hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-(3-hydroxyphenyl)propionate + NADH + oxygen + H+ = 3-(2,3-dihydroxyphenyl)propionate + NAD+ + H2O." [MetaCyc:MHPHYDROXY-RXN]
xref: EC:1.14.13.-
xref: KEGG:R06786
xref: MetaCyc:MHPHYDROXY-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0008689
name: 3-demethylubiquinone-9 3-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinone-9 = S-adenosyl-L-homocysteine + ubiquinone-9." [GOC:dph]
subset: gosubset_prok
synonym: "5-demethylubiquinone-9 methyltransferase activity" EXACT [EC:2.1.1.64]
synonym: "OMHMB-methyltransferase activity" EXACT [EC:2.1.1.64]
synonym: "S-adenosyl-L-methionine:2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone 3-O-methyltransferase activity" EXACT [EC:2.1.1.64]
synonym: "S-adenosyl-L-methionine:2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone-O-methyltransferase activity" EXACT [EC:2.1.1.64]
xref: EC:2.1.1.64
xref: MetaCyc:DHHB-METHYLTRANSFER-RXN
xref: RHEA:17052
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
is_a: GO:0061542 ! 3-demethylubiquinone-n 3-O-methyltransferase activity

[Term]
id: GO:0008690
name: 3-deoxy-manno-octulosonate cytidylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate." [EC:2.7.7.38]
subset: gosubset_prok
synonym: "2-keto-3-deoxyoctonate cytidylyltransferase activity" EXACT [EC:2.7.7.38]
synonym: "3-deoxy-D-manno-octulosonate cytidylyltransferase activity" EXACT [EC:2.7.7.38]
synonym: "CMP-2-keto-3-deoxyoctulosonic acid synthetase activity" EXACT [EC:2.7.7.38]
synonym: "CMP-3-deoxy-D-manno-octulosonate diphosphorylase activity" EXACT [EC:2.7.7.38]
synonym: "CMP-3-deoxy-D-manno-octulosonate pyrophosphorylase activity" EXACT [EC:2.7.7.38]
synonym: "CMP-3-deoxy-D-manno-octulosonate synthetase activity" EXACT [EC:2.7.7.38]
synonym: "CMP-KDO synthetase activity" EXACT [EC:2.7.7.38]
synonym: "CTP:3-deoxy-D-manno-octulosonate cytidylyltransferase activity" EXACT [EC:2.7.7.38]
synonym: "CTP:3-deoxy-manno-octulosonate cytidylyltransferase activity" EXACT []
synonym: "CTP:CMP-3-deoxy-D-manno-octulosonate cytidylyltransferase activity" EXACT [EC:2.7.7.38]
synonym: "cytidine monophospho-3-deoxy-D-manno-octulosonate pyrophosphorylase activity" EXACT [EC:2.7.7.38]
xref: EC:2.7.7.38
xref: MetaCyc:CPM-KDOSYNTH-RXN
xref: RHEA:23451
is_a: GO:0070567 ! cytidylyltransferase activity

[Term]
id: GO:0008691
name: 3-hydroxybutyryl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-3-hydroxybutanoyl-CoA + NADP+ = 3-acetoacetyl-CoA + NADPH + H+." [EC:1.1.1.157]
subset: gosubset_prok
synonym: "(S)-3-hydroxybutanoyl-CoA:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.157]
synonym: "beta-hydroxybutyryl coenzyme A dehydrogenase activity" EXACT [EC:1.1.1.157]
synonym: "beta-hydroxybutyryl-CoA dehydrogenase activity" EXACT [EC:1.1.1.157]
synonym: "BHBD activity" EXACT [EC:1.1.1.157]
synonym: "dehydrogenase, L-3-hydroxybutyryl coenzyme A (nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.1.1.157]
synonym: "L(+)-3-hydroxybutyryl-CoA dehydrogenase activity" EXACT [EC:1.1.1.157]
synonym: "L-(+)-3-hydroxybutyryl-CoA dehydrogenase activity" EXACT [EC:1.1.1.157]
xref: EC:1.1.1.157
xref: MetaCyc:3-HYDROXYBUTYRYL-COA-DEHYDROGENASE-RXN
xref: RHEA:16200
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008692
name: 3-hydroxybutyryl-CoA epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-3-hydroxybutanoyl-CoA = (R)-3-hydroxybutanoyl-CoA." [EC:5.1.2.3]
subset: gosubset_prok
synonym: "3-hydroxyacyl-CoA epimerase activity" EXACT [EC:5.1.2.3]
synonym: "3-hydroxybutanoyl-CoA 3-epimerase activity" EXACT [EC:5.1.2.3]
synonym: "3-hydroxybutyryl coenzyme A epimerase activity" EXACT [EC:5.1.2.3]
xref: EC:5.1.2.3
xref: MetaCyc:OHBUTYRYL-COA-EPIM-RXN
xref: RHEA:21763
is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives

[Term]
id: GO:0008693
name: 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3R)-3-hydroxydecanoyl-[acyl-carrier protein] = 2,3-decenoyl-[acyl-carrier protein] or 3,4-decenoyl-[acyl-carrier protein] + H2O." [EC:4.2.1.60]
subset: gosubset_prok
synonym: "(3R)-3-hydroxydecanoyl-acyl-carrier-protein hydro-lyase activity" EXACT [EC:4.2.1.60]
synonym: "3-hydroxydecanoyl-[acyl-carrier protein] dehydratase activity" EXACT []
synonym: "3-hydroxydecanoyl-ACP dehydratase activity" EXACT []
synonym: "3-hydroxydecanoyl-acyl carrier protein dehydrase activity" EXACT [EC:4.2.1.60]
synonym: "3-hydroxydecanoyl-acyl carrier protein dehydratase activity" EXACT [EC:4.2.1.60]
synonym: "3-hydroxydecanoyl-acyl-carrier-protein dehydratase activity" EXACT [EC:4.2.1.60]
synonym: "beta-hydroxyacyl-ACP dehydrase activity" EXACT [EC:4.2.1.60]
synonym: "beta-hydroxyacyl-acyl carrier protein dehydratase activity" EXACT [EC:4.2.1.60]
synonym: "beta-hydroxydecanoate dehydrase activity" EXACT [EC:4.2.1.60]
synonym: "beta-hydroxydecanoyl thioester dehydrase activity" EXACT [EC:4.2.1.60]
synonym: "beta-hydroxydecanoyl thiol ester dehydrase activity" EXACT [EC:4.2.1.60]
synonym: "D-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity" EXACT [EC:4.2.1.60]
synonym: "D-3-hydroxydecanoyl-acyl-carrier-protein dehydratase activity" EXACT [EC:4.2.1.60]
synonym: "FabA" RELATED [EC:4.2.1.60]
synonym: "HDDase activity" EXACT [EC:4.2.1.60]
xref: EC:4.2.1.60
is_a: GO:0019171 ! 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity

[Term]
id: GO:0008694
name: 3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
namespace: molecular_function
alt_id: GO:0019167
def: "Catalysis of the reaction: 3-octaprenyl-4-hydroxy benzoate = 2-octaprenylphenol + CO2." [MetaCyc:3-OCTAPRENYL-4-OHBENZOATE-DECARBOX-RXN]
subset: gosubset_prok
synonym: "3-octaprenyl-4-hydroxybenzoate decarboxylase activity" EXACT []
synonym: "3-polyprenyl 4-hydroxybenzoate decarboxylase activity" EXACT []
synonym: "3-polyprenyl-4-hydroxybenzoate carboxy-lyase activity" EXACT []
synonym: "polyprenyl p-hydroxybenzoate decarboxylase activity" EXACT []
synonym: "PPHB decarboxylase activity" EXACT []
synonym: "UbiD" RELATED []
synonym: "UbiX" RELATED []
xref: EC:4.1.1.-
xref: MetaCyc:3-OCTAPRENYL-4-OHBENZOATE-DECARBOX-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0008695
name: 3-phenylpropionate dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-phenylpropionate + NADH + H+ + O2 = NAD+ + cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol." [UM-BBD_enzymeID:e0307]
synonym: "3-phenylpropanoate dioxygenase activity" EXACT [EC:1.14.12.19]
synonym: "3-phenylpropanoate,NADH:oxygen oxidoreductase (2,3-hydroxylating) activity" EXACT [EC:1.14.12.19]
synonym: "Hca dioxygenase activity" EXACT [EC:1.14.12.19]
synonym: "HcaA1A2CD" RELATED [EC:1.14.12.19]
xref: EC:1.14.12.19
xref: MetaCyc:HCAMULTI-RXN
xref: RHEA:20360
xref: UM-BBD_enzymeID:e0307
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0008696
name: 4-amino-4-deoxychorismate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-amino-4-deoxychorismate = 4-aminobenzoate + H(+) + pyruvate." [EC:4.1.3.38, RHEA:16204]
comment: Note that the name 'para-amino benzoic acid synthase' was initially given to the 'aminodeoxychorismate synthase' activity before the additional 4-amino-4-deoxychorismate lyase activity was discovered. It is the lyase activity that actually produces para-aminobenzoic acid from 4-amino-4-deoxychorismate.
subset: gosubset_prok
synonym: "4-amino-4-deoxychorismate pyruvate-lyase (4-aminobenzoate-forming)" EXACT [EC:4.1.3.38]
synonym: "4-amino-4-deoxychorismate pyruvate-lyase activity" EXACT [EC:4.1.3.38]
synonym: "ADC lyase activity" EXACT [EC:4.1.3.38]
synonym: "aminodeoxychorismate lyase activity" EXACT []
synonym: "enzyme X activity" RELATED [EC:4.1.3.38]
synonym: "p-aminobenzoate synthetase" RELATED []
synonym: "para-aminobenzoic acid (PABA) synthase" RELATED []
synonym: "para-aminobenzoic acid synthase" RELATED []
xref: EC:4.1.3.38
xref: KEGG:R05553
xref: MetaCyc:ADCLY-RXN
xref: RHEA:16204
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0008697
name: 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-dehydro-4-deoxy-D-glucuronate = 3-deoxy-D-glycero-2,5-hexodiulosonate." [EC:5.3.1.17, RHEA:23899]
subset: gosubset_prok
synonym: "4-deoxy-L-threo-5-hexosulose-uronate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.17]
synonym: "4-deoxy-L-threo-5-hexulose uronate isomerase activity" EXACT [EC:5.3.1.17]
synonym: "5-keto-4-deoxyuronate isomerase activity" EXACT [EC:5.3.1.17]
xref: EC:5.3.1.17
xref: KEGG:R04383
xref: MetaCyc:5.3.1.17-RXN
xref: RHEA:23899
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0008700
name: 4-hydroxy-2-oxoglutarate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate." [EC:4.1.3.16]
subset: gosubset_prok
synonym: "2-keto-4-hydroxybutyrate aldolase activity" EXACT [EC:4.1.3.16]
synonym: "2-keto-4-hydroxyglutarate aldolase activity" EXACT [EC:4.1.3.16]
synonym: "2-keto-4-hydroxyglutaric aldolase activity" EXACT [EC:4.1.3.16]
synonym: "2-oxo-4-hydroxyglutarate aldolase activity" EXACT [EC:4.1.3.16]
synonym: "2-oxo-4-hydroxyglutaric aldolase activity" EXACT [EC:4.1.3.16]
synonym: "4-hydroxy-2-ketoglutarate aldolase activity" EXACT [EC:4.1.3.16]
synonym: "4-hydroxy-2-ketoglutaric aldolase activity" EXACT [EC:4.1.3.16]
synonym: "4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)" EXACT [EC:4.1.3.16]
synonym: "4-hydroxy-2-oxoglutarate glyoxylate-lyase activity" EXACT [EC:4.1.3.16]
synonym: "DL-4-hydroxy-2-ketoglutarate aldolase activity" EXACT [EC:4.1.3.16]
synonym: "hydroxyketoglutarate aldolase activity" EXACT [EC:4.1.3.16]
synonym: "hydroxyketoglutaric aldolase activity" EXACT [EC:4.1.3.16]
synonym: "KHG-aldolase activity" EXACT [EC:4.1.3.16]
xref: EC:4.1.3.16
xref: MetaCyc:4OH2OXOGLUTARALDOL-RXN
xref: RHEA:18172
is_a: GO:0016832 ! aldehyde-lyase activity
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0008701
name: 4-hydroxy-2-oxovalerate aldolase activity
namespace: molecular_function
alt_id: GO:0018804
def: "Catalysis of the reaction: 4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate." [EC:4.1.3.39, RHEA:22627]
synonym: "4-hydroxy-2-ketovalerate aldolase activity" EXACT [EC:4.1.3.39]
synonym: "4-hydroxy-2-oxopentanoate pyruvate-lyase (acetaldehyde-forming) activity" EXACT [EC:4.1.3.39]
synonym: "4-hydroxy-2-oxopentanoate pyruvate-lyase activity" EXACT [EC:4.1.3.39]
synonym: "4-hydroxy-2-oxovalerate pyruvate-lyase activity" EXACT [EC:4.1.3.39]
synonym: "DmpG" RELATED [EC:4.1.3.39]
synonym: "HOA" RELATED [EC:4.1.3.39]
xref: EC:4.1.3.39
xref: KEGG:R00750
xref: MetaCyc:MHPELY-RXN
xref: RHEA:22627
xref: UM-BBD_enzymeID:e0077
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0008703
name: 5-amino-6-(5-phosphoribosylamino)uracil reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-amino-6-(5-phosphoribitylamino)uracil + NADP(+) = 5-amino-6-(5-phosphoribosylamino)uracil + H(+) + NADPH." [EC:1.1.1.193, RHEA:17848]
subset: gosubset_prok
synonym: "5-amino-6-(5'-phosphoribosylamino)uracil reductase activity" EXACT []
synonym: "5-amino-6-(5-phosphoribitylamino)uracil:NADP+ 1'-oxidoreductase activity" EXACT [EC:1.1.1.193]
synonym: "aminodioxyphosphoribosylaminopyrimidine reductase activity" EXACT [EC:1.1.1.193]
xref: EC:1.1.1.193
xref: KEGG:R03458
xref: MetaCyc:RIBOFLAVINSYNREDUC-RXN
xref: RHEA:17848
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008704
name: 5-carboxymethyl-2-hydroxymuconate delta-isomerase activity
namespace: molecular_function
alt_id: GO:0018843
def: "Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate = 5-carboxy-2-oxohept-3-enedioate." [EC:5.3.3.10]
subset: gosubset_prok
synonym: "2-hydroxyhepta-2,4-diene-1,7-dioate isomerase" RELATED []
synonym: "5-carboxymethyl-2-hydroxymuconate D-isomerase activity" EXACT []
synonym: "5-carboxymethyl-2-hydroxymuconate delta2,Delta4-2-oxo,Delta3-isomerase activity" EXACT [EC:5.3.3.10]
synonym: "5-carboxymethyl-2-hydroxymuconic acid isomerase activity" EXACT [EC:5.3.3.10]
synonym: "CHM isomerase activity" EXACT [EC:5.3.3.10]
synonym: "HHDD isomerase activity" EXACT []
synonym: "hpaG-1" RELATED []
synonym: "hpaG1" RELATED []
xref: EC:5.3.3.10
xref: MetaCyc:5.3.3.10-RXN
xref: RHEA:18816
xref: UM-BBD_reactionID:r0366
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0008705
name: methionine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine." [EC:2.1.1.13, RHEA:11175]
subset: gosubset_prok
synonym: "5-methyltetrahydrofolate--homocysteine S-methyltransferase activity" EXACT [EC:2.1.1.13]
synonym: "5-methyltetrahydrofolate--homocysteine transmethylase activity" EXACT [EC:2.1.1.13]
synonym: "5-methyltetrahydrofolate-homocysteine S-methyltransferase activity" EXACT []
synonym: "5-methyltetrahydrofolate:L-homocysteine S-methyltransferase activity" EXACT [EC:2.1.1.13]
synonym: "B12 N(5)-methyltetrahydrofolate homocysteine methyltransferase activity" EXACT [EC:2.1.1.13]
synonym: "B12 N5-methyltetrahydrofolate homocysteine methyltransferase activity" EXACT [EC:2.1.1.13]
synonym: "cobalamin-dependent methionine synthase activity" EXACT [EC:2.1.1.13]
synonym: "MetH" RELATED [EC:2.1.1.13]
synonym: "methionine synthase (cobalamin-dependent) activity" EXACT [EC:2.1.1.13]
synonym: "methyltetrahydrofolate--homocysteine vitamin B12 methyltransferase activity" EXACT [EC:2.1.1.13]
synonym: "N(5)-methyltetrahydrofolate methyltransferase activity" EXACT [EC:2.1.1.13]
synonym: "N(5)-methyltetrahydrofolate--homocysteine cobalamin methyltransferase activity" EXACT [EC:2.1.1.13]
synonym: "N(5)-methyltetrahydrofolic--homocysteine vitamin B12 transmethylase activity" EXACT [EC:2.1.1.13]
synonym: "N-methyltetrahydrofolate:L-homocysteine methyltransferase activity" EXACT [EC:2.1.1.13]
synonym: "N5-methyltetrahydrofolate methyltransferase activity" EXACT [EC:2.1.1.13]
synonym: "N5-methyltetrahydrofolate-homocysteine cobalamin methyltransferase activity" EXACT [EC:2.1.1.13]
synonym: "N5-methyltetrahydrofolic-homocysteine vitamin B12 transmethylase activity" EXACT [EC:2.1.1.13]
synonym: "tetrahydrofolate methyltransferase activity" EXACT [EC:2.1.1.13]
synonym: "tetrahydropteroylglutamate methyltransferase activity" EXACT [EC:2.1.1.13]
synonym: "tetrahydropteroylglutamic methyltransferase activity" EXACT [EC:2.1.1.13]
synonym: "vitamin B12 methyltransferase activity" EXACT [EC:2.1.1.13]
xref: EC:2.1.1.13
xref: KEGG:R00946
xref: MetaCyc:HOMOCYSMETB12-RXN
xref: Reactome:REACT_108964 "Methionine is reformed, Staphylococcus aureus N315"
xref: Reactome:REACT_109401 "Methionine is reformed, Xenopus tropicalis"
xref: Reactome:REACT_32037 "Methionine is reformed, Canis familiaris"
xref: Reactome:REACT_33315 "Methionine is reformed, Rattus norvegicus"
xref: Reactome:REACT_6739 "Methionine is reformed, Homo sapiens"
xref: Reactome:REACT_79867 "Methionine is reformed, Escherichia coli"
xref: Reactome:REACT_82450 "Methionine is reformed, Taeniopygia guttata"
xref: Reactome:REACT_87311 "Methionine is reformed, Mus musculus"
xref: Reactome:REACT_88342 "Methionine is reformed, Mycobacterium tuberculosis"
xref: Reactome:REACT_89478 "Methionine is reformed, Gallus gallus"
xref: Reactome:REACT_91637 "Methionine is reformed, Bos taurus"
xref: Reactome:REACT_92492 "Methionine is reformed, Sus scrofa"
xref: Reactome:REACT_93034 "Methionine is reformed, Caenorhabditis elegans"
xref: Reactome:REACT_97474 "Methionine is reformed, Danio rerio"
xref: Reactome:REACT_98785 "Methionine is reformed, Dictyostelium discoideum"
xref: RHEA:11175
is_a: GO:0008172 ! S-methyltransferase activity
is_a: GO:0042084 ! 5-methyltetrahydrofolate-dependent methyltransferase activity
relationship: part_of GO:0009086 ! methionine biosynthetic process

[Term]
id: GO:0008706
name: 6-phospho-beta-glucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-phospho-beta-D-glucoside-(1,4)-D-glucose + H2O = D-glucose 6-phosphate + glucose." [EC:3.2.1.86]
subset: gosubset_prok
synonym: "6-phospho-beta-D-glucosyl-(1,4)-D-glucose glucohydrolase activity" EXACT [EC:3.2.1.86]
synonym: "phospho-beta-glucosidase A" RELATED [EC:3.2.1.86]
synonym: "phospho-beta-glucosidase activity" EXACT [EC:3.2.1.86]
synonym: "phosphocellobiase activity" EXACT [EC:3.2.1.86]
xref: EC:3.2.1.86
xref: MetaCyc:6-PHOSPHO-BETA-GLUCOSIDASE-RXN
xref: RHEA:10775
is_a: GO:0008422 ! beta-glucosidase activity

[Term]
id: GO:0008707
name: 4-phytase activity
namespace: molecular_function
def: "Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = 1-myo-inositol 1,2,3,4,5-pentakisphosphate + phosphate." [EC:3.1.3.26]
subset: gosubset_prok
synonym: "6-phytase (name based on 1L-numbering system and not 1D-numbering)" BROAD [EC:3.1.3.26]
synonym: "6-phytase activity" EXACT []
synonym: "myo-inositol-hexakisphosphate 6-phosphohydrolase activity" EXACT [EC:3.1.3.26]
synonym: "phytase activity" BROAD [EC:3.1.3.26]
synonym: "phytate 6-phosphatase activity" EXACT [EC:3.1.3.26]
xref: EC:3.1.3.26
xref: MetaCyc:6-PHYT-RXN
xref: RHEA:20963
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0008709
name: cholate 7-alpha-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cholate + NAD(+) = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADH." [EC:1.1.1.159, RHEA:19412]
subset: gosubset_prok
synonym: "7-alpha-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.159]
synonym: "7alpha-HSDH" RELATED [EC:1.1.1.159]
synonym: "7alpha-hydroxy steroid dehydrogenase activity" BROAD [EC:1.1.1.159]
synonym: "7alpha-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.159]
synonym: "7alpha-hydroxysteroid:NAD+ 7-oxidoreductase activity" BROAD [EC:1.1.1.159]
xref: EC:1.1.1.159
xref: KEGG:R02792
xref: MetaCyc:7-ALPHA-HYDROXYSTEROID-DEH-RXN
xref: RHEA:19412
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008710
name: 8-amino-7-oxononanoate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-alanine + H(+) + pimelyl-CoA = 8-amino-7-oxononanoate + CO(2) + CoA." [EC:2.3.1.47, RHEA:20715]
subset: gosubset_prok
synonym: "6-carboxyhexanoyl-CoA:L-alanine C-carboxyhexanoyltransferase (decarboxylating)" EXACT [EC:2.3.1.47]
synonym: "7-KAP synthetase activity" EXACT [EC:2.3.1.47]
synonym: "7-keto-8-amino-pelargonic acid synthetase activity" EXACT [EC:2.3.1.47]
synonym: "7-keto-8-aminopelargonic acid synthetase activity" EXACT [EC:2.3.1.47]
synonym: "7-keto-8-aminopelargonic synthetase activity" EXACT [EC:2.3.1.47]
synonym: "8-amino-7-ketopelargonate synthase activity" EXACT [EC:2.3.1.47]
synonym: "8-amino-7-oxopelargonate synthase activity" EXACT [EC:2.3.1.47]
synonym: "AONS activity" EXACT [EC:2.3.1.47]
xref: EC:2.3.1.47
xref: KEGG:R03210
xref: MetaCyc:7KAPSYN-RXN
xref: RHEA:20715
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0008711
name: obsolete ADP-L-glycero-D-manno-heptose synthase activity
namespace: molecular_function
def: "OBSOLETE." [GOC:curators]
comment: This term was made obsolete because it represents a bifunctional gene product (e.g. E. coli RfaE).
synonym: "ADP-L-glycero-D-manno-heptose synthase activity" EXACT []
is_obsolete: true
consider: GO:0033785
consider: GO:0033786

[Term]
id: GO:0008712
name: ADP-glyceromanno-heptose 6-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: ADP-D-glycero-D-manno-heptose = ADP-L-glycero-D-manno-heptose." [EC:5.1.3.20, RHEA:17580]
subset: gosubset_prok
synonym: "ADP-L-glycero-D-manno-heptose 6-epimerase activity" EXACT [EC:5.1.3.20]
synonym: "ADPglyceromanno-heptose 6-epimerase activity" EXACT [EC:5.1.3.20]
xref: EC:5.1.3.20
xref: KEGG:R05176
xref: MetaCyc:5.1.3.20-RXN
xref: RHEA:17580
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0008713
name: ADP-heptose-lipopolysaccharide heptosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: heptosyl-KDO2-lipid A + ADP-L-glycero-beta-D-manno-heptose = heptosyl2-KDO2-lipid A + ADP + H+." [MetaCyc:RXN0-5061]
subset: gosubset_prok
synonym: "ADP-heptose:LPS heptosyltransferase activity" EXACT [MetaCyc:LIPA-CORESYN-PWY]
xref: MetaCyc:RXN0-5061
is_a: GO:0008920 ! lipopolysaccharide heptosyltransferase activity

[Term]
id: GO:0008714
name: AMP nucleosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: AMP + H(2)O = D-ribose 5-phosphate + adenine." [EC:3.2.2.4, RHEA:20132]
subset: gosubset_prok
synonym: "adenosine monophosphate nucleosidase activity" EXACT [EC:3.2.2.4]
synonym: "adenylate nucleosidase activity" EXACT [EC:3.2.2.4]
synonym: "AMP phosphoribohydrolase activity" EXACT [EC:3.2.2.4]
xref: EC:3.2.2.4
xref: KEGG:R00182
xref: MetaCyc:AMP-NUCLEOSID-RXN
xref: RHEA:20132
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0008715
name: CDP-diacylglycerol diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: CDP-diacylglycerol + H(2)O = a phosphatidate + CMP + 2 H(+)." [EC:3.6.1.26, RHEA:15224]
subset: gosubset_prok
synonym: "CDP diacylglycerol hydrolase activity" EXACT [EC:3.6.1.26]
synonym: "CDP-diacylglycerol phosphatidylhydrolase activity" EXACT [EC:3.6.1.26]
synonym: "CDP-diacylglycerol pyrophosphatase activity" EXACT []
synonym: "cytidine diphosphodiacylglycerol pyrophosphatase activity" EXACT [EC:3.6.1.26]
xref: EC:3.6.1.26
xref: KEGG:R01797
xref: MetaCyc:CDPDIGLYPYPHOSPHA-RXN
xref: RHEA:15224
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0008716
name: D-alanine-D-alanine ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 D-alanine + ATP = D-alanyl-D-alanine + ADP + 2 H(+) + phosphate." [EC:6.3.2.4, RHEA:11227]
subset: gosubset_prok
synonym: "alanine:alanine ligase (ADP-forming) activity" EXACT [EC:6.3.2.4]
synonym: "alanylalanine synthetase activity" EXACT [EC:6.3.2.4]
synonym: "D-Ala-D-Ala synthetase activity" EXACT [EC:6.3.2.4]
synonym: "D-alanine:D-alanine ligase (ADP-forming)" EXACT [EC:6.3.2.4]
synonym: "D-alanyl-D-alanine synthetase activity" EXACT [EC:6.3.2.4]
synonym: "D-alanylalanine synthetase activity" EXACT [EC:6.3.2.4]
xref: EC:6.3.2.4
xref: KEGG:R01150
xref: MetaCyc:DALADALALIG-RXN
xref: RHEA:11227
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0008717
name: obsolete D-alanyl-D-alanine endopeptidase activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "D-alanyl-D-alanine endopeptidase activity" EXACT []
synonym: "penicillin-binding protein 7" NARROW []
synonym: "penicillin-binding protein 8" NARROW []
xref: EC:3.4.99.-
is_obsolete: true
replaced_by: GO:0004175

[Term]
id: GO:0008718
name: D-amino-acid dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a D-amino acid + H2O + acceptor = a 2-oxo acid + NH3 + reduced acceptor." [EC:1.4.99.1]
subset: gosubset_prok
synonym: "D-amino-acid:(acceptor) oxidoreductase (deaminating)" EXACT [EC:1.4.99.1]
synonym: "D-amino-acid:acceptor oxidoreductase (deaminating)" EXACT [EC:1.4.99.1]
xref: EC:1.4.99.1
xref: MetaCyc:DAADEHYDROG-RXN
xref: RHEA:18128
is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors

[Term]
id: GO:0008719
name: dihydroneopterin triphosphate 2'-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: dihydroneopterin triphosphate = dihydromonapterin-triphosphate." [MetaCyc:H2NTPEPIM-RXN]
subset: gosubset_prok
synonym: "D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase activity" EXACT []
xref: EC:5.-.-.-
xref: MetaCyc:H2NTPEPIM-RXN
is_a: GO:0016853 ! isomerase activity

[Term]
id: GO:0008720
name: D-lactate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-lactate + NAD(+) = H(+) + NADH + pyruvate." [EC:1.1.1.28, RHEA:16372]
subset: gosubset_prok
synonym: "D-lactic acid dehydrogenase activity" EXACT [EC:1.1.1.28]
synonym: "D-lactic dehydrogenase activity" EXACT [EC:1.1.1.28]
xref: EC:1.1.1.28
xref: KEGG:R00704
xref: MetaCyc:DLACTDEHYDROGNAD-RXN
xref: RHEA:16372
is_a: GO:0004457 ! lactate dehydrogenase activity
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008721
name: D-serine ammonia-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-serine = pyruvate + NH3." [EC:4.3.1.18]
comment: Note that this function was formerly EC:4.3.1.14.
subset: gosubset_prok
synonym: "D-hydroxy amino acid dehydratase activity" BROAD [EC:4.3.1.18]
synonym: "D-hydroxyaminoacid dehydratase activity" EXACT [EC:4.3.1.18]
synonym: "D-serine ammonia-lyase (pyruvate-forming)" EXACT [EC:4.3.1.18]
synonym: "D-serine deaminase activity" EXACT [EC:4.3.1.18]
synonym: "D-serine dehydrase activity" EXACT [EC:4.3.1.18]
synonym: "D-serine dehydratase (deaminating) activity" EXACT [EC:4.3.1.18]
synonym: "D-serine dehydratase activity" EXACT [EC:4.3.1.18]
synonym: "D-serine hydro-lyase (deaminating) activity" EXACT [EC:4.3.1.18]
synonym: "D-serine hydrolase activity" EXACT [EC:4.3.1.18]
xref: EC:4.3.1.18
xref: MetaCyc:DSERDEAM-RXN
xref: RHEA:13980
is_a: GO:0016841 ! ammonia-lyase activity

[Term]
id: GO:0008724
name: obsolete DNA topoisomerase IV activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the ATP-independent breakage of DNA, followed by passage and rejoining. It also catalyzes the relaxation of supercoiled DNA, and the decatenation and unknotting of DNA in vivo." [EC:5.99.1.-, PMID:11274059]
comment: This term was made obsolete because it represents a gene product.
synonym: "DNA topoisomerase IV activity" EXACT []
is_obsolete: true
replaced_by: GO:0003918

[Term]
id: GO:0008725
name: DNA-3-methyladenine glycosylase activity
namespace: molecular_function
def: "Catalysis of the reaction: DNA containing 3-methyladenine + H2O = DNA with abasic site + 3-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methyladenine and the deoxyribose sugar to remove the 3-methyladenine, leaving an abasic site." [EC:3.2.2.20, GOC:elh, PMID:10872450, PMID:9224623]
subset: gosubset_prok
synonym: "3-methyladenine DNA glycosylase I" RELATED [EC:3.2.2.20]
synonym: "alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)" BROAD [EC:3.2.2.20]
synonym: "deoxyribonucleate 3-methyladenine glycosidase I" RELATED [EC:3.2.2.20]
synonym: "DNA glycosidase I activity" RELATED [EC:3.2.2.20]
synonym: "DNA-3-methyladenine glycosidase I activity" EXACT [EC:3.2.2.20]
synonym: "DNA-3-methyladenine glycosylase I activity" EXACT []
xref: EC:3.2.2.20
xref: EC:3.2.2.21
xref: MetaCyc:3.2.2.20-RXN
xref: MetaCyc:3.2.2.21-RXN
is_a: GO:0043733 ! DNA-3-methylbase glycosylase activity

[Term]
id: GO:0008726
name: alkanesulfonate monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: an alkanesulfonate + O2 + FMNH2 = an aldehyde + sulfite + H2O + FMN." [MetaCyc:RXN0-280]
subset: gosubset_prok
synonym: "alkanesulfonate, reduced-FMN:oxygen oxidoreductase activity" EXACT [EC:1.14.14.5]
synonym: "alkanesulphonate monooxygenase activity" EXACT []
synonym: "FMNH(2)-dependent aliphatic sulfonate monooxygenase activity" EXACT [EC:1.14.14.5]
synonym: "FMNH(2)-dependent alkanesulfonate monooxygenase activity" EXACT []
synonym: "FMNH2-dependent aliphatic sulfonate monooxygenase activity" EXACT [EC:1.14.14.5]
synonym: "SsuD" RELATED [EC:1.14.14.5]
synonym: "sulfate starvation-induced protein 6 activity" RELATED [EC:1.14.14.5]
xref: EC:1.14.14.5
xref: MetaCyc:RXN0-280
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0008727
name: GDP-mannose mannosyl hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-alpha-D-mannose + H2O = GDP + D-mannose + H+." [MetaCyc:GDPMANMANHYDRO-RXN]
xref: MetaCyc:GDPMANMANHYDRO-RXN
is_a: GO:0015923 ! mannosidase activity

[Term]
id: GO:0008728
name: GTP diphosphokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate." [EC:2.7.6.5]
subset: gosubset_prok
synonym: "(p)ppGpp synthetase I" RELATED [EC:2.7.6.5]
synonym: "(p)ppGpp synthetase II" RELATED [EC:2.7.6.5]
synonym: "ATP-GTP 3'-diphosphotransferase activity" EXACT [EC:2.7.6.5]
synonym: "ATP:GTP 3'-diphosphotransferase activity" EXACT [EC:2.7.6.5]
synonym: "GPSI" RELATED [EC:2.7.6.5]
synonym: "GPSII" RELATED [EC:2.7.6.5]
synonym: "GTP pyrophosphokinase activity" EXACT []
synonym: "guanosine 3',5'-polyphosphate synthase activity" EXACT [EC:2.7.6.5]
synonym: "guanosine 5',3'-polyphosphate synthetase activity" EXACT [EC:2.7.6.5]
synonym: "guanosine pentaphosphate synthetase activity" EXACT [EC:2.7.6.5]
synonym: "ppGpp synthetase I activity" EXACT [EC:2.7.6.5]
synonym: "stringent factor activity" RELATED [EC:2.7.6.5]
xref: EC:2.7.6.5
xref: MetaCyc:GTPPYPHOSKIN-RXN
xref: RHEA:22091
is_a: GO:0016778 ! diphosphotransferase activity

[Term]
id: GO:0008730
name: L(+)-tartrate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tartrate = H(2)O + oxaloacetate." [EC:4.2.1.32, RHEA:15416]
subset: gosubset_prok
synonym: "(R,R)-tartrate hydro-lyase (oxaloacetate-forming)" EXACT [EC:4.2.1.32]
synonym: "(R,R)-tartrate hydro-lyase activity" EXACT [EC:4.2.1.32]
synonym: "L-(+)-tartaric acid dehydratase activity" EXACT [EC:4.2.1.32]
synonym: "L-tartrate dehydratase activity" EXACT [EC:4.2.1.32]
synonym: "tartaric acid dehydrase activity" EXACT [EC:4.2.1.32]
synonym: "tartrate dehydratase activity" EXACT [EC:4.2.1.32]
xref: EC:4.2.1.32
xref: KEGG:R00339
xref: MetaCyc:LTARTDEHYDRA-RXN
xref: RHEA:15416
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0008732
name: L-allo-threonine aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-allo-threonine = glycine + acetaldehyde." [MetaCyc:LTAA-RXN, PMID:9228760]
subset: gosubset_prok
synonym: "L-allo-threonine acetaldehyde-lyase activity" EXACT []
synonym: "LtaA" RELATED []
xref: EC:4.1.2.-
xref: MetaCyc:LTAA-RXN
is_a: GO:0004793 ! threonine aldolase activity

[Term]
id: GO:0008733
name: L-arabinose isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arabinose = L-ribulose." [EC:5.3.1.4, RHEA:14824]
subset: gosubset_prok
synonym: "L-arabinose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.4]
synonym: "L-arabinose ketol-isomerase activity" EXACT [EC:5.3.1.4]
xref: EC:5.3.1.4
xref: KEGG:R01761
xref: MetaCyc:ARABISOM-RXN
xref: RHEA:14824
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0008734
name: L-aspartate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-aspartate + O2 = iminosuccinate + hydrogen peroxide." [EC:1.4.3.16]
subset: gosubset_prok
synonym: "L-aspartate:oxygen oxidoreductase" EXACT [EC:1.4.3.16]
xref: EC:1.4.3.16
xref: MetaCyc:L-ASPARTATE-OXID-RXN
xref: MetaCyc:RXN-9772
xref: RHEA:25879
is_a: GO:0001716 ! L-amino-acid oxidase activity
is_a: GO:0015922 ! aspartate oxidase activity

[Term]
id: GO:0008735
name: carnitine dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-carnitine = crotono-betaine + H(2)O." [EC:4.2.1.89, RHEA:14580]
subset: gosubset_prok
synonym: "L-carnitine dehydratase activity" EXACT []
synonym: "L-carnitine hydro-lyase [4-(trimethylammonio)but-2-enoate-forming]" RELATED [EC:4.2.1.89]
synonym: "L-carnitine hydro-lyase activity" EXACT [EC:4.2.1.89]
xref: EC:4.2.1.89
xref: KEGG:R01925
xref: MetaCyc:CARNDEHYDRA-RXN
xref: RHEA:14580
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0008736
name: L-fucose isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-fucose = L-fuculose." [EC:5.3.1.25]
subset: gosubset_prok
synonym: "L-fucose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.25]
synonym: "L-fucose ketol-isomerase activity" EXACT [EC:5.3.1.25]
xref: EC:5.3.1.25
xref: MetaCyc:FUCISOM-RXN
xref: RHEA:17236
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0008737
name: L-fuculokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-fuculose + ATP = L-fuculose 1-phosphate + ADP + 2 H(+)." [EC:2.7.1.51, RHEA:12379]
subset: gosubset_prok
synonym: "ATP:L-fuculose 1-phosphotransferase activity" EXACT [EC:2.7.1.51]
synonym: "L-fuculokinase (phosphorylating)" EXACT [EC:2.7.1.51]
synonym: "L-fuculose kinase activity" EXACT [EC:2.7.1.51]
xref: EC:2.7.1.51
xref: KEGG:R03241
xref: MetaCyc:FUCULOKIN-RXN
xref: RHEA:12379
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0008738
name: L-fuculose-phosphate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-fuculose 1-phosphate = (S)-lactaldehyde + glycerone phosphate." [EC:4.1.2.17, RHEA:12936]
subset: gosubset_prok
synonym: "fuculose aldolase activity" EXACT [EC:4.1.2.17]
synonym: "L-fuculose 1-phosphate aldolase activity" EXACT [EC:4.1.2.17]
synonym: "L-fuculose-1-phosphate lactaldehyde-lyase activity" EXACT [EC:4.1.2.17]
synonym: "L-fuculose-1-phosphate S-lactaldehyde-lyase (glycerone-phosphate-forming)" EXACT [EC:4.1.2.17]
xref: EC:4.1.2.17
xref: KEGG:R02262
xref: MetaCyc:FUCPALDOL-RXN
xref: RHEA:12936
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0008740
name: L-rhamnose isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-rhamnose = L-rhamnulose." [EC:5.3.1.14, RHEA:23163]
subset: gosubset_prok
synonym: "L-rhamnose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.14]
synonym: "L-rhamnose ketol-isomerase activity" EXACT [EC:5.3.1.14]
synonym: "rhamnose isomerase activity" EXACT [EC:5.3.1.14]
xref: EC:5.3.1.14
xref: KEGG:R02437
xref: MetaCyc:RHAMNISOM-RXN
xref: RHEA:23163
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0008741
name: ribulokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L(or D)-ribulose = ADP + L(or D)-ribulose 5-phosphate." [EC:2.7.1.16]
subset: gosubset_prok
synonym: "ATP:L(or D)-ribulose 5-phosphotransferase activity" EXACT [EC:2.7.1.16]
synonym: "L-ribulokinase activity" EXACT []
synonym: "ribulokinase (phosphorylating)" EXACT [EC:2.7.1.16]
xref: EC:2.7.1.16
xref: MetaCyc:RIBULOKIN-RXN
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0008742
name: L-ribulose-phosphate 4-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-ribulose 5-phosphate = D-xylulose 5-phosphate." [EC:5.1.3.4, RHEA:22371]
subset: gosubset_prok
synonym: "AraD" RELATED [EC:5.1.3.4]
synonym: "L-ribulose 5-phosphate 4-epimerase activity" EXACT [EC:5.1.3.4]
synonym: "L-ribulose-5-phosphate 4-epimerase" BROAD [EC:5.1.3.4]
synonym: "L-Ru5P" RELATED [EC:5.1.3.4]
synonym: "L-ru5P activity" EXACT [EC:5.1.3.4]
synonym: "phosphoribulose isomerase activity" EXACT [EC:5.1.3.4]
synonym: "ribulose phosphate 4-epimerase activity" EXACT [EC:5.1.3.4]
xref: EC:5.1.3.4
xref: KEGG:R05850
xref: MetaCyc:RIBULPEPIM-RXN
xref: RHEA:22371
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0008743
name: L-threonine 3-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-threonine + NAD(+) = aminoacetone + CO(2) + NADH." [EC:1.1.1.103, RHEA:25657]
subset: gosubset_prok
synonym: "L-threonine dehydrogenase activity" EXACT [EC:1.1.1.103]
synonym: "L-threonine:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.103]
synonym: "threonine 3-dehydrogenase activity" BROAD []
synonym: "threonine dehydrogenase activity" EXACT [EC:1.1.1.103]
xref: EC:1.1.1.103
xref: KEGG:R01465
xref: MetaCyc:THREODEHYD-RXN
xref: RHEA:25657
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008744
name: L-xylulokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-xylulose = ADP + L-xylulose 5-phosphate." [EC:2.7.1.53]
subset: gosubset_prok
synonym: "ATP:L-xylulose 5-phosphotransferase activity" EXACT [EC:2.7.1.53]
synonym: "L-xylulokinase (phosphorylating)" EXACT [EC:2.7.1.53]
synonym: "L-xylulose kinase activity" EXACT [EC:2.7.1.53]
xref: EC:2.7.1.53
xref: MetaCyc:LYXK-RXN
xref: RHEA:18872
is_a: GO:0004856 ! xylulokinase activity

[Term]
id: GO:0008745
name: N-acetylmuramoyl-L-alanine amidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides." [EC:3.5.1.28]
subset: gosubset_prok
synonym: "acetylmuramoyl-alanine amidase activity" EXACT [EC:3.5.1.28]
synonym: "acetylmuramyl-alanine amidase activity" EXACT [EC:3.5.1.28]
synonym: "acetylmuramyl-L-alanine amidase activity" EXACT [EC:3.5.1.28]
synonym: "murein hydrolase activity" EXACT [EC:3.5.1.28]
synonym: "N-acetylmuramic acid L-alanine amidase activity" EXACT [EC:3.5.1.28]
synonym: "N-acetylmuramoyl-L-alanine amidase type I" RELATED [EC:3.5.1.28]
synonym: "N-acetylmuramoyl-L-alanine amidase type II" RELATED [EC:3.5.1.28]
synonym: "N-acetylmuramyl-L-alanine amidase activity" EXACT [EC:3.5.1.28]
synonym: "N-acetylmuramylalanine amidase activity" EXACT [EC:3.5.1.28]
synonym: "N-acylmuramyl-L-alanine amidase activity" EXACT [EC:3.5.1.28]
synonym: "peptidoglycan amidohydrolase activity" EXACT [EC:3.5.1.28]
xref: EC:3.5.1.28
xref: MetaCyc:3.5.1.28-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0008746
name: NAD(P)+ transhydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+." [EC:1.6.1.1, EC:1.6.1.2]
subset: gosubset_prok
synonym: "energy-linked transhydrogenase" EXACT [EC:1.6.1.1, EC:1.6.1.2]
synonym: "H+-thase" BROAD [EC:1.6.1.1, EC:1.6.1.2]
synonym: "NAD transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2]
synonym: "NADH transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2]
synonym: "NADH-NADP-transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2]
synonym: "NADPH-NAD oxidoreductase" BROAD [EC:1.6.1.1, EC:1.6.1.2]
synonym: "NADPH-NAD transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2]
synonym: "NADPH:NAD+ transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2]
synonym: "nicotinamide adenine dinucleotide (phosphate) transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2]
synonym: "pyridine nucleotide transferase" BROAD [EC:1.6.1.1, EC:1.6.1.2]
xref: EC:1.6.1.-
xref: KEGG:R00112
xref: Reactome:REACT_21342 "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix], Homo sapiens"
xref: RHEA:11695
is_a: GO:0016652 ! oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor

[Term]
id: GO:0008747
name: N-acetylneuraminate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate." [EC:4.1.3.3, RHEA:23299]
subset: gosubset_prok
synonym: "acetylneuraminate lyase activity" EXACT [EC:4.1.3.3]
synonym: "acetylneuraminate pyruvate-lyase activity" EXACT [EC:4.1.3.3]
synonym: "N-acetylneuraminate aldolase activity" EXACT [EC:4.1.3.3]
synonym: "N-acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)" EXACT [EC:4.1.3.3]
synonym: "N-acetylneuraminate pyruvate-lyase activity" EXACT [EC:4.1.3.3]
synonym: "N-acetylneuraminic acid aldolase activity" EXACT [EC:4.1.3.3]
synonym: "N-acetylneuraminic acid lyase activity" EXACT [EC:4.1.3.3]
synonym: "N-acetylneuraminic aldolase activity" EXACT [EC:4.1.3.3]
synonym: "N-acetylneuraminic lyase activity" EXACT [EC:4.1.3.3]
synonym: "NALase activity" EXACT [EC:4.1.3.3]
synonym: "NANA lyase activity" EXACT [EC:4.1.3.3]
synonym: "neuraminate aldolase activity" EXACT [EC:4.1.3.3]
synonym: "neuraminic acid aldolase activity" EXACT [EC:4.1.3.3]
synonym: "neuraminic aldolase activity" EXACT [EC:4.1.3.3]
synonym: "NPL" RELATED [EC:4.1.3.3]
synonym: "sialate lyase activity" EXACT [EC:4.1.3.3]
synonym: "sialic acid aldolase activity" EXACT [EC:4.1.3.3]
synonym: "sialic aldolase activity" EXACT [EC:4.1.3.3]
xref: EC:4.1.3.3
xref: KEGG:R01811
xref: MetaCyc:ACNEULY-RXN
xref: RHEA:23299
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0008748
name: N-ethylmaleimide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-ethylmaleimide + NADPH + 2 H+ = N-ethylsuccinimide + NADP+." [MetaCyc:RXN0-5101]
subset: gosubset_prok
xref: EC:1.-.-.-
xref: MetaCyc:RXN0-5101
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008750
name: NAD(P)+ transhydrogenase (AB-specific) activity
namespace: molecular_function
def: "Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD+ and B-specific (i.e. the pro-S hydrogen is transferred) with respect to NADP+." [EC:1.6.1.2, http://pubs.acs.org/cgi-bin/abstract.cgi/jacsat/1991/113/i07/f-pdf/f_ja00007a002.pdf]
subset: gosubset_prok
synonym: "NAD(P) transhydrogenase (AB-specific) activity" EXACT [EC:1.6.1.2]
synonym: "NADPH:NAD+ oxidoreductase (AB-specific)" EXACT [EC:1.6.1.2]
synonym: "pyridine nucleotide transhydrogenase activity" BROAD [EC:1.6.1.2]
synonym: "transhydrogenase activity" BROAD [EC:1.6.1.2]
xref: EC:1.6.1.2
xref: MetaCyc:1.6.1.2-RXN
is_a: GO:0008746 ! NAD(P)+ transhydrogenase activity

[Term]
id: GO:0008751
name: obsolete NAD(P)H dehydrogenase
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it is a redundant grouping term with only one child.
synonym: "NAD(P)H dehydrogenase" EXACT []
is_obsolete: true
consider: GO:0016651

[Term]
id: GO:0008752
name: FMN reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: FMNH2 + NAD(P)+ = FMN + NAD(P)H + H+." [EC:1.5.1.29]
comment: This term represents a deleted EC activity and is scheduled for obsoletion.
subset: mf_needs_review
synonym: "flavin mononucleotide reductase activity" EXACT [EC:1.5.1.29]
synonym: "flavine mononucleotide reductase activity" EXACT [EC:1.5.1.29]
synonym: "FMNH2:NAD(P)+ oxidoreductase activity" EXACT [EC:1.5.1.29]
synonym: "NAD(P)H dehydrogenase (FMN) activity" EXACT []
synonym: "NAD(P)H(2) dehydrogenase (FMN) activity" EXACT [EC:1.5.1.29]
synonym: "NAD(P)H(2):FMN oxidoreductase activity" EXACT [EC:1.5.1.29]
synonym: "NAD(P)H-dependent FMN reductase activity" EXACT [EC:1.5.1.29]
synonym: "NAD(P)H-FMN reductase activity" EXACT [EC:1.5.1.29]
synonym: "NAD(P)H2 dehydrogenase (FMN)" EXACT [EC:1.5.1.29]
synonym: "NAD(P)H2:FMN oxidoreductase activity" EXACT [EC:1.5.1.29]
synonym: "NAD(P)H:flavin oxidoreductase activity" EXACT [EC:1.5.1.29]
synonym: "NAD(P)H:FMN oxidoreductase activity" EXACT [EC:1.5.1.29]
synonym: "riboflavin mononucleotide (reduced nicotinamide adenine dinucleotide (phosphate)) reductase activity" EXACT [EC:1.5.1.29]
synonym: "riboflavin mononucleotide reductase activity" BROAD [EC:1.5.1.29]
synonym: "riboflavine mononucleotide reductase activity" BROAD [EC:1.5.1.29]
synonym: "SsuE" RELATED [EC:1.5.1.29]
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008753
name: NADPH dehydrogenase (quinone) activity
namespace: molecular_function
def: "Catalysis of the reaction: NADPH + H+ + acceptor = NADP+ + reduced acceptor." [EC:1.6.5.10]
subset: gosubset_prok
synonym: "NADPH oxidase" BROAD [EC:1.6.5.10]
synonym: "NADPH:(quinone-acceptor) oxidoreductase" EXACT [EC:1.6.5.10]
synonym: "reduced nicotinamide adenine dinucleotide phosphate (quinone) dehydrogenase" EXACT [EC:1.6.5.10]
xref: EC:1.6.5.10
xref: KEGG:R07359
xref: MetaCyc:NADPH-DEHYDROGENASE-QUINONE-RXN
xref: RHEA:13152
is_a: GO:0016655 ! oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor

[Term]
id: GO:0008754
name: O antigen ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: Lipid A-core + colanic acid = MLPS." [MetaCyc:RXN0-5294]
xref: MetaCyc:RXN0-5294
is_a: GO:0016874 ! ligase activity

[Term]
id: GO:0008755
name: O antigen polymerase activity
namespace: molecular_function
def: "Catalysis of the polymerization of o-antigen chains. O-antigens are tetra- and pentasaccharide repeat units of the cell walls of Gram-negative bacteria and are a component of lipopolysaccharide." [GOC:jl, PMID:12045108]
subset: gosubset_prok
synonym: "O-antigen polymerase activity" EXACT []
xref: EC:2.4.1.-
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0008756
name: o-succinylbenzoate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-succinylbenzoate + ATP + CoA = 2-succinylbenzoyl-CoA + AMP + diphosphate." [EC:6.2.1.26]
subset: gosubset_prok
synonym: "2-succinylbenzoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.26]
synonym: "o-succinylbenzoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.26]
synonym: "o-succinylbenzoyl-CoA synthetase activity" EXACT [EC:6.2.1.26]
synonym: "o-succinylbenzoyl-coenzyme A synthetase activity" EXACT [EC:6.2.1.26]
synonym: "OSB-CoA synthetase activity" EXACT [EC:6.2.1.26]
xref: EC:6.2.1.26
xref: KEGG:R04030
xref: MetaCyc:O-SUCCINYLBENZOATE-COA-LIG-RXN
xref: RHEA:17012
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0008757
name: S-adenosylmethionine-dependent methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]
subset: gosubset_prok
synonym: "S-adenosyl methionine-dependent methyltransferase activity" EXACT []
synonym: "SAM-dependent methyltransferase activity" EXACT []
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0008758
name: UDP-2,3-diacylglucosamine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + UDP-2,3-bis(3-hydroxymyristoyl)glucosamine = 2,3-bis(3-hydroxymyristoyl)-beta-D-glucosaminyl 1-phosphate + UMP." [MetaCyc:LIPIDXSYNTHESIS-RXN, PMID:12000770]
subset: gosubset_prok
xref: EC:3.6.1.-
xref: MetaCyc:LIPIDXSYNTHESIS-RXN
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0008759
name: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
namespace: molecular_function
def: "Catalysis of the removal of an acetyl group from the 2-N position of glucosamine in the lipid A precursor UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine." [PMID:10026271]
subset: gosubset_prok
xref: EC:3.5.1.-
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0019213 ! deacetylase activity

[Term]
id: GO:0008760
name: UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine." [EC:2.5.1.7, RHEA:18684]
subset: gosubset_prok
synonym: "enoylpyruvate transferase activity" EXACT [EC:2.5.1.7]
synonym: "MurA transferase activity" NARROW [EC:2.5.1.7]
synonym: "phosphoenolpyruvate-UDP-acetylglucosamine-3-enolpyruvyltransferase activity" EXACT [EC:2.5.1.7]
synonym: "phosphoenolpyruvate:UDP-2-acetamido-2-deoxy-D-glucose 2-enoyl-1-carboxyethyltransferase activity" EXACT [EC:2.5.1.7]
synonym: "phosphoenolpyruvate:UDP-N-acetyl-D-glucosamine 1-carboxyvinyltransferase activity" EXACT [EC:2.5.1.7]
synonym: "phosphoenolpyruvate:uridine diphosphate N-acetylglucosamine enolpyruvyltransferase activity" EXACT [EC:2.5.1.7]
synonym: "phosphoenolpyruvate:uridine-5'-diphospho-N-acetyl-2-amino-2-deoxyglucose 3-enolpyruvyltransferase activity" EXACT [EC:2.5.1.7]
synonym: "phosphopyruvate-uridine diphosphoacetylglucosamine pyruvatetransferase activity" EXACT [EC:2.5.1.7]
synonym: "pyruvate-UDP-acetylglucosamine transferase activity" EXACT [EC:2.5.1.7]
synonym: "pyruvate-uridine diphospho-N-acetyl-glucosamine transferase activity" EXACT [EC:2.5.1.7]
synonym: "pyruvate-uridine diphospho-N-acetylglucosamine transferase activity" EXACT [EC:2.5.1.7]
synonym: "pyruvic-uridine diphospho-N-acetylglucosaminyltransferase activity" EXACT [EC:2.5.1.7]
synonym: "UDP-N-acetylglucosamine 1-carboxyvinyl-transferase activity" EXACT [EC:2.5.1.7]
synonym: "UDP-N-acetylglucosamine enoylpyruvyltransferase activity" EXACT [EC:2.5.1.7]
xref: EC:2.5.1.7
xref: KEGG:R00660
xref: MetaCyc:UDPNACETYLGLUCOSAMENOLPYRTRANS-RXN
xref: RHEA:18684
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0008761
name: UDP-N-acetylglucosamine 2-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-mannosamine." [EC:5.1.3.14]
subset: gosubset_prok
synonym: "UDP-GlcNAc-2-epimerase activity" EXACT [EC:5.1.3.14]
synonym: "UDP-N-acetyl-D-glucosamine 2-epimerase activity" EXACT [EC:5.1.3.14]
synonym: "UDP-N-acetylglucosamine 2'-epimerase activity" EXACT [EC:5.1.3.14]
synonym: "uridine diphosphate-N-acetylglucosamine-2'-epimerase activity" EXACT [EC:5.1.3.14]
synonym: "uridine diphospho-N-acetylglucosamine 2'-epimerase activity" EXACT [EC:5.1.3.14]
synonym: "uridine diphosphoacetylglucosamine 2'-epimerase activity" EXACT [EC:5.1.3.14]
xref: EC:5.1.3.14
xref: MetaCyc:UDPGLCNACEPIM-RXN
xref: RHEA:17216
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0008762
name: UDP-N-acetylmuramate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH + H+." [EC:1.1.1.158]
subset: gosubset_prok
synonym: "MurB reductase" RELATED [EC:1.1.1.158]
synonym: "UDP-GlcNAc-enoylpyruvate reductase activity" EXACT [EC:1.1.1.158]
synonym: "UDP-N-acetylenolpyruvoylglucosamine reductase activity" EXACT [EC:1.1.1.158]
synonym: "UDP-N-acetylglucosamine-enoylpyruvate reductase activity" EXACT [EC:1.1.1.158]
synonym: "UDP-N-acetylmuramate:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.158]
synonym: "uridine diphospho-N-acetylglucosamine-enolpyruvate reductase activity" EXACT [EC:1.1.1.158]
synonym: "uridine diphosphoacetylpyruvoylglucosamine reductase activity" EXACT [EC:1.1.1.158]
synonym: "uridine-5'-diphospho-N-acetyl-2-amino-2-deoxy-3-O-lactylglucose:NADP-oxidoreductase activity" EXACT [EC:1.1.1.158]
xref: EC:1.1.1.158
xref: MetaCyc:UDPNACETYLMURAMATEDEHYDROG-RXN
xref: RHEA:12251
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008763
name: UDP-N-acetylmuramate-L-alanine ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-alanine + ATP + UDP-N-acetylmuramate = ADP + 2 H(+) + phosphate + UDP-N-acetylmuramoyl-L-alanine." [EC:6.3.2.8, RHEA:23375]
subset: gosubset_prok
synonym: "alanine-adding enzyme activity" RELATED [EC:6.3.2.8]
synonym: "L-Ala ligase activity" RELATED [EC:6.3.2.8]
synonym: "L-alanine-adding enzyme activity" RELATED [EC:6.3.2.8]
synonym: "MurC synthetase activity" NARROW [EC:6.3.2.8]
synonym: "UDP-acetylmuramyl-L-alanine synthetase activity" EXACT [EC:6.3.2.8]
synonym: "UDP-MurNAc:L-alanine ligase activity" EXACT [EC:6.3.2.8]
synonym: "UDP-N-acetylmuramate:L-alanine ligase (ADP-forming)" EXACT [EC:6.3.2.8]
synonym: "UDP-N-acetylmuramoyl-L-alanine synthetase activity" EXACT [EC:6.3.2.8]
synonym: "UDP-N-acetylmuramoylalanine synthetase activity" EXACT [EC:6.3.2.8]
synonym: "UDP-N-acetylmuramyl:L-alanine ligase activity" EXACT [EC:6.3.2.8]
synonym: "UDPMurNAc-L-alanine synthetase activity" EXACT [EC:6.3.2.8]
synonym: "uridine 5'-diphosphate-N-acetylmuramyl-L-alanine synthetase activity" EXACT [EC:6.3.2.8]
synonym: "uridine diphosphate N-acetylmuramate:L-alanine ligase activity" EXACT [EC:6.3.2.8]
synonym: "uridine diphospho-N-acetylmuramoylalanine synthetase activity" EXACT [EC:6.3.2.8]
synonym: "uridine-diphosphate-N-acetylmuramate:L-alanine ligase activity" EXACT [EC:6.3.2.8]
xref: EC:6.3.2.8
xref: KEGG:R03193
xref: MetaCyc:UDP-NACMUR-ALA-LIG-RXN
xref: RHEA:23375
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0008764
name: UDP-N-acetylmuramoylalanine-D-glutamate ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glutamate + ATP + UDP-N-acetylmuramoyl-L-alanine = ADP + 2 H(+) + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate." [EC:6.3.2.9, RHEA:16432]
subset: gosubset_prok
synonym: "D-glutamate ligase activity" RELATED [EC:6.3.2.9]
synonym: "D-glutamate-adding enzyme activity" RELATED [EC:6.3.2.9]
synonym: "MurD synthetase activity" EXACT [EC:6.3.2.9]
synonym: "UDP-Mur-NAC-L-Ala:D-Glu ligase activity" EXACT [EC:6.3.2.9]
synonym: "UDP-N-acetylmuramoyl-L-alanine:glutamate ligase (ADP-forming)" EXACT [EC:6.3.2.9]
synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase activity" EXACT [EC:6.3.2.9]
synonym: "uridine diphospho-N-acetylmuramoylalanyl-D-glutamate synthetase activity" EXACT [EC:6.3.2.9]
xref: EC:6.3.2.9
xref: KEGG:R02783
xref: MetaCyc:UDP-NACMURALA-GLU-LIG-RXN
xref: RHEA:16432
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0008765
name: UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: meso-2,6-diaminopimelate + ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate = ADP + 2 H(+) + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminoheptanedioate." [EC:6.3.2.13, RHEA:23679]
subset: gosubset_prok
synonym: "MurE synthetase activity" RELATED [EC:6.3.2.13]
synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:(L)-meso-2,6-diaminoheptanedioate gamma-ligase (ADP-forming)" EXACT [EC:6.3.2.13]
synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-2,6-diamino-heptanedioate ligase (ADP-forming) activity" EXACT [EC:6.3.2.13]
synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate synthetase activity" EXACT [EC:6.3.2.13]
synonym: "UDP-N-acetylmuramyl-tripeptide synthetase activity" EXACT [EC:6.3.2.13]
xref: EC:6.3.2.13
xref: KEGG:R02788
xref: MetaCyc:UDP-NACMURALGLDAPLIG-RXN
xref: RHEA:23679
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0008766
name: UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine." [EC:6.3.2.15]
comment: Note that EC:6.3.2.15 was deleted from EC as the reaction is performed by UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase (EC:6.3.2.10).
subset: gosubset_prok
xref: EC:6.3.2.-
xref: MetaCyc:UDP-NACMURALGLDAPAALIG-RXN
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0008767
name: UDP-galactopyranose mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-D-galactopyranose = UDP-D-galacto-1,4-furanose." [EC:5.4.99.9]
subset: gosubset_prok
synonym: "UDP-D-galactopyranose furanomutase activity" EXACT [EC:5.4.99.9]
synonym: "UDPgalactopyranose mutase activity" EXACT [EC:5.4.99.9]
xref: EC:5.4.99.9
xref: MetaCyc:GALPMUT-RXN
xref: RHEA:24135
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0008768
name: UDP-sugar diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-sugar + H2O = UMP + sugar 1-phosphate." [EC:3.6.1.45]
subset: gosubset_prok
synonym: "nucleosidediphosphate-sugar diphosphatase activity" EXACT [EC:3.6.1.45]
synonym: "nucleosidediphosphate-sugar pyrophosphatase activity" EXACT [EC:3.6.1.45]
synonym: "UDP-sugar hydrolase activity" EXACT [EC:3.6.1.45]
synonym: "UDP-sugar pyrophosphatase activity" EXACT [EC:3.6.1.45]
synonym: "UDP-sugar sugarphosphohydrolase activity" EXACT [EC:3.6.1.45]
xref: EC:3.6.1.45
xref: MetaCyc:UDPSUGARHYDRO-RXN
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0008769
name: obsolete X-His dipeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of Xaa-His dipeptides." [EC:3.4.13.3]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "aminoacyl-histidine dipeptidase activity" EXACT [EC:3.4.13.3]
synonym: "aminoacylhistidine dipeptidase activity" EXACT [EC:3.4.13.3]
synonym: "carnosinase activity" RELATED [EC:3.4.13.3]
synonym: "dipeptidase M" RELATED [EC:3.4.13.3]
synonym: "homocarnosinase activity" RELATED [EC:3.4.13.3]
synonym: "X-His dipeptidase activity" EXACT []
synonym: "Xaa-His dipeptidase activity" EXACT []
xref: EC:3.4.13.3
xref: MetaCyc:3.4.13.3-RXN
is_obsolete: true
consider: GO:0008235
consider: GO:0016805

[Term]
id: GO:0008770
name: [acyl-carrier-protein] phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: [acyl-carrier protein] + H2O = 4'-phosphopantetheine + apoprotein." [EC:3.1.4.14]
subset: gosubset_prok
synonym: "[acyl-carrier protein] phosphodiesterase activity" EXACT []
synonym: "[acyl-carrier-protein] 4'-pantetheine-phosphohydrolase activity" EXACT [EC:3.1.4.14]
synonym: "ACP hydrolyase activity" EXACT [EC:3.1.4.14]
synonym: "ACP phosphodiesterase activity" EXACT []
synonym: "AcpH" RELATED [EC:3.1.4.14]
synonym: "acyl-carrier-protein 4'-pantetheine-phosphohydrolase activity" EXACT [EC:3.1.4.14]
synonym: "acyl-carrier-protein phosphodiesterase activity" EXACT [EC:3.1.4.14]
synonym: "holo-acyl-carrier-protein 4'-pantetheine-phosphohydrolase activity" EXACT [EC:3.1.4.14]
xref: EC:3.1.4.14
xref: MetaCyc:3.1.4.14-RXN
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0008771
name: [citrate (pro-3S)-lyase] ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + acetate + (citrate (pro-3S)-lyase) (thiol form) = AMP + diphosphate + (citrate (pro-3S)-lyase) (acetyl form)." [EC:6.2.1.22]
subset: gosubset_prok
synonym: "acetate: SH-acyl-carrier-protein enzyme ligase (AMP)" EXACT [EC:6.2.1.22]
synonym: "acetate:citrate-(pro-3S)-lyase(thiol-form) ligase (AMP-forming)" BROAD [EC:6.2.1.22]
synonym: "acetate:HS-citrate lyase ligase activity" EXACT [EC:6.2.1.22]
synonym: "citrate (pro-3S)-lyase ligase activity" EXACT [EC:6.2.1.22]
synonym: "citrate lyase ligase activity" EXACT [EC:6.2.1.22]
synonym: "citrate lyase synthetase activity" EXACT [EC:6.2.1.22]
xref: EC:6.2.1.22
xref: KEGG:R04449
xref: MetaCyc:CITC-RXN
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0008772
name: [isocitrate dehydrogenase (NADP+)] kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + (isocitrate dehydrogenase (NADP)) = ADP + (isocitrate dehydrogenase (NADP)) phosphate." [EC:2.7.11.5]
subset: gosubset_prok
synonym: "ATP:isocitrate dehydrogenase (NADP+) phosphotransferase activity" EXACT [EC:2.7.11.5]
synonym: "ICDH kinase/phosphatase activity" EXACT [EC:2.7.11.5]
synonym: "IDH kinase activity" EXACT [EC:2.7.11.5]
synonym: "IDH kinase/phosphatase activity" EXACT [EC:2.7.11.5]
synonym: "IDH-K/P" RELATED [EC:2.7.11.5]
synonym: "IDHK/P" RELATED [EC:2.7.11.5]
synonym: "isocitrate dehydrogenase (NADP) kinase activity" EXACT [EC:2.7.11.5]
synonym: "isocitrate dehydrogenase (NADP+) kinase activity" EXACT [EC:2.7.11.5]
synonym: "isocitrate dehydrogenase kinase (phosphorylating) activity" EXACT [EC:2.7.11.5]
synonym: "isocitrate dehydrogenase kinase activity" EXACT [EC:2.7.11.5]
synonym: "isocitrate dehydrogenase kinase/phosphatase activity" EXACT [EC:2.7.11.5]
synonym: "STK3" RELATED [EC:2.7.11.5]
xref: EC:2.7.11.5
xref: MetaCyc:PHOSICITDEHASE-RXN
is_a: GO:0004672 ! protein kinase activity

[Term]
id: GO:0008773
name: [protein-PII] uridylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UTP + (protein-PII) = diphosphate + uridylyl-(protein-PII)." [EC:2.7.7.59]
subset: gosubset_prok
synonym: "PII uridylyl-transferase activity" EXACT [EC:2.7.7.59]
synonym: "protein-PII uridylyltransferase activity" EXACT [EC:2.7.7.59]
synonym: "uridyl removing enzyme" RELATED [EC:2.7.7.59]
synonym: "uridylyl removing enzyme activity" BROAD [EC:2.7.7.59]
synonym: "UTP:[protein-PII] uridylyltransferase activity" EXACT []
synonym: "UTP:protein-PII uridylyltransferase activity" EXACT [EC:2.7.7.59]
xref: EC:2.7.7.59
xref: MetaCyc:URITRANS-RXN
is_a: GO:0070569 ! uridylyltransferase activity

[Term]
id: GO:0008774
name: acetaldehyde dehydrogenase (acetylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH + H+." [EC:1.2.1.10]
subset: gosubset_prok
synonym: "acetaldehyde:NAD+ oxidoreductase (CoA-acetylating)" EXACT [EC:1.2.1.10]
synonym: "acylating acetaldehyde dehydrogenase activity" EXACT [EC:1.2.1.10]
synonym: "ADA" RELATED [EC:1.2.1.10]
synonym: "aldehyde dehydrogenase (acylating) activity" EXACT [EC:1.2.1.10]
synonym: "DmpF" RELATED [EC:1.2.1.10]
xref: EC:1.2.1.10
xref: MetaCyc:ACETALD-DEHYDROG-RXN
xref: RHEA:23291
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008775
name: acetate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + acetate = a fatty acid anion + acetyl-CoA." [EC:2.8.3.8]
subset: gosubset_prok
synonym: "acetate coenzyme A-transferase activity" EXACT [EC:2.8.3.8]
synonym: "acetyl-CoA:acetoacetate CoA transferase activity" EXACT [EC:2.8.3.8]
synonym: "acyl-CoA:acetate CoA-transferase activity" EXACT [EC:2.8.3.8]
synonym: "butyryl CoA:acetate CoA transferase activity" EXACT [EC:2.8.3.8]
synonym: "butyryl coenzyme A transferase activity" EXACT [EC:2.8.3.8]
synonym: "succinyl-CoA:acetate CoA transferase activity" EXACT [EC:2.8.3.8]
xref: EC:2.8.3.8
xref: MetaCyc:ACECOATRANS-RXN
xref: RHEA:13384
xref: UM-BBD_enzymeID:e0012
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0008776
name: acetate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + acetate = ADP + acetyl phosphate." [EC:2.7.2.1]
subset: gosubset_prok
synonym: "acetate kinase (phosphorylating) activity" EXACT [EC:2.7.2.1]
synonym: "acetic kinase activity" EXACT [EC:2.7.2.1]
synonym: "acetokinase activity" EXACT [EC:2.7.2.1]
synonym: "AckA" RELATED [EC:2.7.2.1]
synonym: "AK activity" EXACT [EC:2.7.2.1]
synonym: "ATP:acetate phosphotransferase activity" EXACT [EC:2.7.2.1]
xref: EC:2.7.2.1
xref: MetaCyc:ACETATEKIN-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor

[Term]
id: GO:0008777
name: acetylornithine deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N2-acetyl-L-ornithine + H2O = acetate + L-ornithine." [EC:3.5.1.16]
subset: gosubset_prok
synonym: "2-N-acetyl-L-ornithine amidohydrolase activity" EXACT [EC:3.5.1.16]
synonym: "acetylornithinase activity" BROAD [EC:3.5.1.16]
synonym: "N-acetylornithinase activity" BROAD [EC:3.5.1.16]
synonym: "N2-acetyl-L-ornithine amidohydrolase activity" EXACT [EC:3.5.1.16]
xref: EC:3.5.1.16
xref: MetaCyc:ACETYLORNDEACET-RXN
xref: RHEA:15944
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0019213 ! deacetylase activity

[Term]
id: GO:0008779
name: acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + O-(2-acyl-sn-glycero-3-phospho)ethanolamine = [acyl-carrier protein] + O-(1-beta-acyl-2-acyl-sn-glycero-3-phospho)ethanolamine." [EC:2.3.1.40]
synonym: "acyl-[acyl-carrier protein]-phospholipid O-acyltransferase activity" EXACT []
synonym: "acyl-ACP-phospholipid O-acyltransferase activity" EXACT []
synonym: "acyl-acyl-carrier-protein-phospholipid O-acyltransferase activity" EXACT [EC:2.3.1.40]
synonym: "acyl-acyl-carrier-protein:O-(2-acyl-sn-glycero-3-phospho)-ethanolamine O-acyltransferase activity" EXACT [EC:2.3.1.40]
xref: EC:2.3.1.40
xref: MetaCyc:ACYLGPEACYLTRANS-RXN
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0008780
name: acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-3-hydroxytetradecanoyl-[acyl-carrier protein] + UDP-N-acetylglucosamine = [acyl-carrier protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine." [EC:2.3.1.129]
subset: gosubset_prok
synonym: "(R)-3-hydroxytetradecanoyl-acyl-carrier-protein:UDP-N-acetylglucosamine 3-O-(3-hydroxytetradecanoyl)transferase activity" EXACT [EC:2.3.1.129]
synonym: "acyl-[acyl-carrier protein]-UDP-N-acetylglucosamine O-acyltransferase activity" EXACT []
synonym: "acyl-ACP-UDP-N-acetylglucosamine O-acyltransferase activity" EXACT []
synonym: "acyl-acyl-carrier-protein-UDP-N-acetylglucosamine O-acyltransferase" BROAD [EC:2.3.1.129]
synonym: "UDP-N-acetylglucosamine acyltransferase activity" EXACT [EC:2.3.1.129]
synonym: "uridine diphosphoacetylglucosamine acyltransferase activity" EXACT [EC:2.3.1.129]
xref: EC:2.3.1.129
xref: MetaCyc:UDPNACETYLGLUCOSAMACYLTRANS-RXN
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0008781
name: N-acylneuraminate cytidylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate." [EC:2.7.7.43]
subset: gosubset_prok
synonym: "acetylneuraminate cytidylyltransferase activity" EXACT [EC:2.7.7.43]
synonym: "acylneuraminate cytidyltransferase activity" EXACT [EC:2.7.7.43]
synonym: "CMP-N-acetylneuraminate synthase activity" EXACT [EC:2.7.7.43]
synonym: "CMP-N-acetylneuraminate synthetase activity" EXACT [EC:2.7.7.43]
synonym: "CMP-N-acetylneuraminic acid synthase activity" EXACT [EC:2.7.7.43]
synonym: "CMP-N-acetylneuraminic acid synthetase activity" EXACT [EC:2.7.7.43]
synonym: "CMP-NANA synthetase activity" EXACT [EC:2.7.7.43]
synonym: "CMP-Neu5Ac synthetase activity" EXACT [EC:2.7.7.43]
synonym: "CMP-NeuAc synthetase activity" EXACT [EC:2.7.7.43]
synonym: "CMP-NeuNAc synthetase activity" EXACT [EC:2.7.7.43]
synonym: "CMP-sialate diphosphorylase activity" EXACT [EC:2.7.7.43]
synonym: "CMP-sialate pyrophosphorylase activity" EXACT [EC:2.7.7.43]
synonym: "CMP-sialate synthase activity" EXACT [EC:2.7.7.43]
synonym: "CMP-sialate synthetase activity" EXACT [EC:2.7.7.43]
synonym: "CMP-sialic acid synthetase activity" EXACT [EC:2.7.7.43]
synonym: "CMP-sialic synthetase activity" EXACT [EC:2.7.7.43]
synonym: "CTP:N-acylneuraminate cytidylyltransferase activity" EXACT []
synonym: "cytidine 5'-monophospho-N-acetylneuraminic acid synthetase activity" EXACT [EC:2.7.7.43]
synonym: "cytidine 5'-monophosphosialic acid synthetase activity" EXACT [EC:2.7.7.43]
synonym: "cytidine 5-monophosphate N-acetylneuraminic acid synthetase activity" EXACT [EC:2.7.7.43]
synonym: "cytidine monophosphoacetylneuraminic synthetase activity" EXACT [EC:2.7.7.43]
synonym: "cytidine monophosphosialate pyrophosphorylase activity" EXACT [EC:2.7.7.43]
synonym: "cytidine monophosphosialate synthetase activity" EXACT [EC:2.7.7.43]
synonym: "cytidine monophosphosialic acid synthetase activity" EXACT [EC:2.7.7.43]
xref: EC:2.7.7.43
xref: MetaCyc:ACYLNEURAMINATE-CYTIDYLYLTRANSFERASE-RXN
xref: RHEA:11347
is_a: GO:0070567 ! cytidylyltransferase activity

[Term]
id: GO:0008782
name: adenosylhomocysteine nucleosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenine + S-D-ribosyl-L-homocysteine." [EC:3.2.2.9]
subset: gosubset_prok
synonym: "5'-methyladenosine nucleosidase activity" EXACT [EC:3.2.2.9]
synonym: "AdoHcy/MTA nucleosidase activity" EXACT [EC:3.2.2.9]
synonym: "S-adenosyl-L-homocysteine homocysteinylribohydrolase activity" EXACT [EC:3.2.2.9]
synonym: "S-adenosylhomocysteine hydrolase activity" BROAD [EC:3.2.2.9]
synonym: "S-adenosylhomocysteine nucleosidase activity" EXACT [EC:3.2.2.9]
synonym: "S-adenosylhomocysteine/5'-methylthioadenosine nucleosidase activity" EXACT [EC:3.2.2.9]
xref: EC:3.2.2.9
xref: MetaCyc:ADENOSYLHOMOCYSTEINE-NUCLEOSIDASE-RXN
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0008783
name: agmatinase activity
namespace: molecular_function
def: "Catalysis of the reaction: agmatine + H(2)O = putrescine + urea." [EC:3.5.3.11, RHEA:13932]
subset: gosubset_prok
synonym: "agmatine amidinohydrolase" BROAD [EC:3.5.3.11]
synonym: "agmatine ureohydrolase activity" EXACT [EC:3.5.3.11]
synonym: "SpeB" RELATED [EC:3.5.3.11]
xref: EC:3.5.3.11
xref: KEGG:R01157
xref: MetaCyc:AGMATIN-RXN
xref: Reactome:REACT_103984 "Agmatine + H2O <=> putrescine + urea, Bos taurus"
xref: Reactome:REACT_108092 "Agmatine + H2O <=> putrescine + urea, Sus scrofa"
xref: Reactome:REACT_14815 "Agmatine + H2O <=> putrescine + urea, Homo sapiens"
xref: Reactome:REACT_28792 "Agmatine + H2O <=> putrescine + urea, Gallus gallus"
xref: Reactome:REACT_30296 "Agmatine + H2O <=> putrescine + urea, Canis familiaris"
xref: Reactome:REACT_77801 "Agmatine + H2O <=> putrescine + urea, Danio rerio"
xref: Reactome:REACT_78445 "Agmatine + H2O <=> putrescine + urea, Escherichia coli"
xref: Reactome:REACT_81086 "Agmatine + H2O <=> putrescine + urea, Taeniopygia guttata"
xref: Reactome:REACT_82589 "Agmatine + H2O <=> putrescine + urea, Rattus norvegicus"
xref: Reactome:REACT_95165 "Agmatine + H2O <=> putrescine + urea, Schizosaccharomyces pombe"
xref: Reactome:REACT_95304 "Agmatine + H2O <=> putrescine + urea, Mus musculus"
xref: Reactome:REACT_99744 "Agmatine + H2O <=> putrescine + urea, Xenopus tropicalis"
xref: RHEA:13932
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0008784
name: alanine racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-alanine = D-alanine." [EC:5.1.1.1, RHEA:20252]
subset: gosubset_prok
synonym: "L-alanine racemase activity" EXACT [EC:5.1.1.1]
xref: EC:5.1.1.1
xref: KEGG:R00401
xref: MetaCyc:ALARACECAT-RXN
xref: RHEA:20252
is_a: GO:0047661 ! amino-acid racemase activity

[Term]
id: GO:0008785
name: alkyl hydroperoxide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: octane hydroperoxide + NADH + H+ = H2O + NAD+ + 1-octanol." [UM-BBD_reactionID:r0684]
subset: gosubset_prok
xref: EC:1.8.1.-
xref: UM-BBD_reactionID:r0684
is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor

[Term]
id: GO:0008786
name: allose 6-phosphate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-allose-6-phosphate = D-allulose-6-phosphate." [MetaCyc:RXN0-303]
xref: EC:5.3.1.-
xref: MetaCyc:RXN0-303
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0008787
name: allose kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-allose = ADP + D-allose 6-phosphate." [EC:2.7.1.55]
subset: gosubset_prok
synonym: "allokinase (phosphorylating)" EXACT [EC:2.7.1.55]
synonym: "allokinase activity" EXACT [EC:2.7.1.55]
synonym: "ATP:D-allose 6-phosphotransferase activity" EXACT [EC:2.7.1.55]
synonym: "D-allokinase activity" EXACT [EC:2.7.1.55]
synonym: "D-allose-6-kinase activity" EXACT [EC:2.7.1.55]
xref: EC:2.7.1.55
xref: MetaCyc:ALLOSE-KINASE-RXN
xref: RHEA:14808
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0008788
name: alpha,alpha-phosphotrehalase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha,alpha-trehalose 6-phosphate + H2O = D-glucose + D-glucose 6-phosphate." [EC:3.2.1.93]
subset: gosubset_prok
synonym: "alpha,alpha-trehalose-6-phosphate phosphoglucohydrolase activity" EXACT [EC:3.2.1.93]
synonym: "phosphotrehalase activity" EXACT [EC:3.2.1.93]
synonym: "trehalose-6-phosphate hydrolase activity" EXACT [EC:3.2.1.93]
xref: EC:3.2.1.93
xref: MetaCyc:TRE6PHYDRO-RXN
xref: RHEA:23011
is_a: GO:0015927 ! trehalase activity

[Term]
id: GO:0008789
name: altronate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-altronate = 2-dehydro-3-deoxy-D-gluconate + H(2)O." [EC:4.2.1.7, RHEA:15960]
subset: gosubset_prok
synonym: "D-altronate hydro-lyase (2-dehydro-3-deoxy-D-galactonate-forming)" EXACT [EC:4.2.1.7]
synonym: "D-altronate hydro-lyase activity" EXACT [EC:4.2.1.7]
xref: EC:4.2.1.7
xref: KEGG:R01540
xref: MetaCyc:ALTRODEHYDRAT-RXN
xref: RHEA:15960
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0008790
name: arabinose isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-arabinose = D-ribulose." [EC:5.3.1.3]
synonym: "D-arabinose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.3]
synonym: "D-arabinose isomerase activity" NARROW [EC:5.3.1.3]
synonym: "D-arabinose ketol-isomerase activity" EXACT [EC:5.3.1.3]
synonym: "D-arabinose(L-fucose) isomerase activity" EXACT [EC:5.3.1.3]
xref: EC:5.3.1.3
xref: MetaCyc:DARABISOM-RXN
xref: RHEA:13852
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0008791
name: arginine N-succinyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: succinyl-CoA + L-arginine = CoA + N2-succinyl-L-arginine." [EC:2.3.1.109]
subset: gosubset_prok
synonym: "AOST activity" EXACT [EC:2.3.1.109]
synonym: "arginine and ornithine N(2)-succinyltransferase activity" EXACT [EC:2.3.1.109]
synonym: "arginine and ornithine N2-succinyltransferase activity" EXACT [EC:2.3.1.109]
synonym: "arginine succinyltransferase activity" EXACT [EC:2.3.1.109]
synonym: "AST activity" EXACT [EC:2.3.1.109]
synonym: "AstA" RELATED [EC:2.3.1.109]
synonym: "succinyl-CoA:L-arginine 2-N-succinyltransferase activity" EXACT [EC:2.3.1.109]
synonym: "succinyl-CoA:L-arginine N2-succinyltransferase activity" EXACT [EC:2.3.1.109]
xref: EC:2.3.1.109
xref: MetaCyc:ARGININE-N-SUCCINYLTRANSFERASE-RXN
xref: RHEA:15188
is_a: GO:0016749 ! N-succinyltransferase activity

[Term]
id: GO:0008792
name: arginine decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arginine + H(+) = agmatine + CO(2)." [EC:4.1.1.19, RHEA:17644]
subset: gosubset_prok
synonym: "L-arginine carboxy-lyase (agmatine-forming)" EXACT [EC:4.1.1.19]
synonym: "L-arginine carboxy-lyase activity" EXACT [EC:4.1.1.19]
synonym: "SpeA" RELATED [EC:4.1.1.19]
xref: EC:4.1.1.19
xref: KEGG:R00566
xref: MetaCyc:ARGDECARBOX-RXN
xref: Reactome:REACT_102735 "Arginine<=>Agmatine+CO2, Mus musculus"
xref: Reactome:REACT_105329 "Arginine<=>Agmatine+CO2, Canis familiaris"
xref: Reactome:REACT_110173 "Arginine<=>Agmatine+CO2, Schizosaccharomyces pombe"
xref: Reactome:REACT_112250 "Arginine<=>Agmatine+CO2, Staphylococcus aureus N315"
xref: Reactome:REACT_115439 "Arginine<=>Agmatine+CO2, Drosophila melanogaster"
xref: Reactome:REACT_14806 "Arginine<=>Agmatine+CO2, Homo sapiens"
xref: Reactome:REACT_28420 "Arginine<=>Agmatine+CO2, Gallus gallus"
xref: Reactome:REACT_29623 "Arginine<=>Agmatine+CO2, Saccharomyces cerevisiae"
xref: Reactome:REACT_32646 "Arginine<=>Agmatine+CO2, Sus scrofa"
xref: Reactome:REACT_79432 "Arginine<=>Agmatine+CO2, Taeniopygia guttata"
xref: Reactome:REACT_83171 "Arginine<=>Agmatine+CO2, Bos taurus"
xref: Reactome:REACT_88254 "Arginine<=>Agmatine+CO2, Dictyostelium discoideum"
xref: Reactome:REACT_94852 "Arginine<=>Agmatine+CO2, Rattus norvegicus"
xref: Reactome:REACT_95070 "Arginine<=>Agmatine+CO2, Xenopus tropicalis"
xref: RHEA:17644
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0008793
name: aromatic-amino-acid:2-oxoglutarate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: an aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate." [EC:2.6.1.57]
subset: gosubset_prok
synonym: "ArAT" RELATED [EC:2.6.1.57]
synonym: "aromatic amino acid aminotransferase activity" EXACT [EC:2.6.1.57]
synonym: "aromatic amino acid transferase activity" EXACT []
synonym: "aromatic aminotransferase activity" EXACT []
synonym: "aromatic-amino-acid transaminase activity" EXACT [EC:2.6.1.57]
xref: EC:2.6.1.57
xref: MetaCyc:2.6.1.57-RXN
xref: UM-BBD_reactionID:r0297
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0008794
name: arsenate reductase (glutaredoxin) activity
namespace: molecular_function
def: "Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + oxidized glutaredoxin. Glutaredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is ( NADPH -> glutathione reductase (EC:1.6.4.2) -> ) glutathione -> glutaredoxin -> arsenate reductase, i.e. glutathione is reduced by glutathione reductase and glutaredoxin is reduced by glutathione." [EC:1.20.4.1, GOC:kd, PMID:10593884]
subset: gosubset_prok
synonym: "glutharedoxin:arsenate oxidoreductase activity" EXACT [EC:1.20.4.1]
xref: EC:1.20.4.1
xref: MetaCyc:RXN-982
xref: UM-BBD_reactionID:r0635
is_a: GO:0030611 ! arsenate reductase activity
is_a: GO:0030614 ! oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor

[Term]
id: GO:0008795
name: NAD+ synthase activity
namespace: molecular_function
alt_id: GO:0008749
alt_id: GO:0016965
def: "Catalysis of the reaction: ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+." [EC:6.3.1.5]
subset: gosubset_prok
synonym: "deamido-NAD+:ammonia ligase (AMP-forming)" EXACT [EC:6.3.1.5]
synonym: "diphosphopyridine nucleotide synthetase activity" EXACT [EC:6.3.1.5]
synonym: "NAD synthase (AMP-forming)" EXACT []
synonym: "NAD synthase activity" EXACT []
synonym: "NAD synthetase activity" EXACT [EC:6.3.1.5]
synonym: "NAD(+) synthetase activity" EXACT [EC:6.3.1.5]
synonym: "NAD+ synthetase activity" EXACT [EC:6.3.1.5]
synonym: "nicotinamide adenine dinucleotide synthetase activity" EXACT [EC:6.3.1.5]
xref: EC:6.3.1.5
xref: MetaCyc:NAD-SYNTH-NH3-RXN
xref: RHEA:21191
is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity

[Term]
id: GO:0008796
name: bis(5'-nucleosyl)-tetraphosphatase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of P(1),P(4)-bis(5'-nucleosyl)tetraphosphate into two nucleotides." [GOC:ai]
subset: gosubset_prok
xref: EC:3.6.1.-
is_a: GO:0004551 ! nucleotide diphosphatase activity

[Term]
id: GO:0008797
name: aspartate ammonia-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-aspartate = fumarate + NH3." [EC:4.3.1.1]
subset: gosubset_prok
synonym: "aspartase activity" EXACT [EC:4.3.1.1]
synonym: "fumaric aminase activity" EXACT [EC:4.3.1.1]
synonym: "L-aspartase activity" EXACT [EC:4.3.1.1]
synonym: "L-aspartate ammonia-lyase (fumarate-forming)" EXACT [EC:4.3.1.1]
synonym: "L-aspartate ammonia-lyase activity" EXACT [EC:4.3.1.1]
xref: EC:4.3.1.1
xref: MetaCyc:ASPARTASE-RXN
xref: RHEA:16604
is_a: GO:0016841 ! ammonia-lyase activity

[Term]
id: GO:0008798
name: beta-aspartyl-peptidase activity
namespace: molecular_function
def: "Catalysis of the cleavage of a beta-linked aspartic residue from the N-terminus of a polypeptide." [EC:3.4.19.5]
subset: gosubset_prok
synonym: "beta-aspartyl dipeptidase activity" EXACT [EC:3.4.19.5]
synonym: "beta-aspartyl peptidase activity" EXACT [EC:3.4.19.5]
xref: EC:3.4.19.5
xref: MetaCyc:3.4.19.5-RXN
is_a: GO:0008242 ! omega peptidase activity

[Term]
id: GO:0008800
name: beta-lactamase activity
namespace: molecular_function
def: "Catalysis of the reaction: a beta-lactam + H2O = a substituted beta-amino acid." [EC:3.5.2.6]
subset: gosubset_prok
synonym: "ampicillinase activity" EXACT [EC:3.5.2.6]
synonym: "beta-lactam hydrolase activity" EXACT [EC:3.5.2.6]
synonym: "beta-lactamase A, B, C" RELATED [EC:3.5.2.6]
synonym: "beta-lactamase AME I" RELATED [EC:3.5.2.6]
synonym: "beta-lactamase I-III" RELATED [EC:3.5.2.6]
synonym: "cephalosporin-beta-lactamase activity" EXACT [EC:3.5.2.6]
synonym: "exopenicillinase activity" EXACT [EC:3.5.2.6]
synonym: "neutrapen" RELATED [EC:3.5.2.6]
synonym: "penicillin amido-beta-lactamhydrolase activity" EXACT [EC:3.5.2.6]
synonym: "penicillin beta-lactamase activity" EXACT [EC:3.5.2.6]
synonym: "penicillinase I, II" RELATED [EC:3.5.2.6]
xref: EC:3.5.2.6
xref: MetaCyc:BETA-LACTAMASE-RXN
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0008801
name: beta-phosphoglucomutase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-D-glucose 1-phosphate = beta-D-glucose 6-phosphate." [EC:5.4.2.6, RHEA:20116]
subset: gosubset_prok
synonym: "beta-D-glucose 1,6-phosphomutase activity" EXACT [EC:5.4.2.6]
xref: EC:5.4.2.6
xref: KEGG:R02728
xref: MetaCyc:BETA-PHOSPHOGLUCOMUTASE-RXN
xref: RHEA:20116
is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases

[Term]
id: GO:0008802
name: betaine-aldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: betaine aldehyde + NAD+ + H2O = betaine + NADH + H+." [EC:1.2.1.8]
subset: gosubset_prok
synonym: "BADH activity" EXACT [EC:1.2.1.8]
synonym: "betaine aldehyde dehydrogenase activity" EXACT [EC:1.2.1.8]
synonym: "betaine aldehyde oxidase activity" EXACT [EC:1.2.1.8]
synonym: "betaine-aldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.8]
synonym: "BetB" RELATED [EC:1.2.1.8]
xref: EC:1.2.1.8
xref: MetaCyc:BADH-RXN
xref: RHEA:15308
is_a: GO:0004029 ! aldehyde dehydrogenase (NAD) activity

[Term]
id: GO:0008803
name: bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity
namespace: molecular_function
def: "Catalysis of the reaction: P(1),P(4)-bis(5'-adenosyl) tetraphosphate + H(2)O = 2 ADP + 2 H(+)." [EC:3.6.1.41, RHEA:24255]
subset: gosubset_prok
synonym: "1-P,4-P-bis(5'-nucleosyl)-tetraphosphate nucleosidebisphosphohydrolase activity" EXACT [EC:3.6.1.41]
synonym: "adenosine tetraphosphate phosphodiesterase activity" EXACT [EC:3.6.1.41]
synonym: "Ap(4)A hydrolase activity" BROAD [EC:3.6.1.41]
synonym: "Ap4A hydrolase activity" BROAD [EC:3.6.1.41]
synonym: "bis(5'-adenosyl) tetraphosphatase activity" EXACT [EC:3.6.1.41]
synonym: "diadenosine 5',5'''-P(1),P(4)-tetraphosphate pyrophosphohydrolase activity" EXACT [EC:3.6.1.41]
synonym: "diadenosine 5',5'''-P1,P4-tetraphosphatase activity" EXACT [EC:3.6.1.41]
synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase activity" EXACT [EC:3.6.1.41]
synonym: "diadenosine polyphosphate hydrolase activity" EXACT [EC:3.6.1.41]
synonym: "diadenosine tetraphosphatase (symmetrical)" NARROW []
synonym: "diadenosine tetraphosphate hydrolase activity" EXACT [EC:3.6.1.41]
synonym: "diadenosinetetraphosphatase (symmetrical) activity" EXACT [EC:3.6.1.41]
synonym: "dinucleosidetetraphosphatase (symmetrical) activity" EXACT [EC:3.6.1.41]
synonym: "dinucleosidetetraphosphate (symmetrical)" RELATED [EC:3.6.1.41]
synonym: "P1,P4-bis(5'-nucleosyl)-tetraphosphate nucleosidebisphosphohydrolase activity" EXACT [EC:3.6.1.41]
synonym: "symmetrical diadenosine tetraphosphate hydrolase activity" EXACT [EC:3.6.1.41]
xref: EC:3.6.1.41
xref: KEGG:R00125
xref: MetaCyc:3.6.1.41-RXN
xref: RHEA:24255
is_a: GO:0008796 ! bis(5'-nucleosyl)-tetraphosphatase activity

[Term]
id: GO:0008804
name: carbamate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + NH3 + CO2 = ADP + carbamoyl phosphate." [EC:2.7.2.2]
subset: gosubset_prok
synonym: "ATP:carbamate phosphotransferase activity" EXACT [EC:2.7.2.2]
synonym: "carbamoyl phosphokinase activity" EXACT [EC:2.7.2.2]
synonym: "carbamyl phosphokinase activity" EXACT [EC:2.7.2.2]
synonym: "CKase activity" EXACT [EC:2.7.2.2]
xref: EC:2.7.2.2
xref: MetaCyc:CARBAMATE-KINASE-RXN
xref: RHEA:10155
is_a: GO:0016301 ! kinase activity
is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor

[Term]
id: GO:0008805
name: carbon-monoxide oxygenase activity
namespace: molecular_function
alt_id: GO:0018999
alt_id: GO:0047767
def: "Catalysis of the reaction: CO + H2O + ferrocytochrome b-561 = CO2 + 2 H+ + 2 ferricytochrome b-561." [EC:1.2.2.4]
synonym: "carbon monoxide oxidase activity" EXACT [EC:1.2.2.4]
synonym: "carbon monoxide oxygenase (cytochrome b-561) activity" NARROW [EC:1.2.2.4]
synonym: "carbon monoxide oxygenase activity" EXACT []
synonym: "carbon monoxide,water:cytochrome b-561 oxidoreductase activity" EXACT [EC:1.2.2.4]
synonym: "carbon monoxide:methylene blue oxidoreductase activity" NARROW [EC:1.2.2.4]
synonym: "carbon-monoxide dehydrogenase (cytochrome b-561)" EXACT [EC:1.2.2.4]
synonym: "cytochrome b561" NARROW []
xref: EC:1.2.2.4
xref: MetaCyc:1.2.2.4-RXN
xref: UM-BBD_reactionID:r0650
xref: Wikipedia:Carbon-monoxide_dehydrogenase_(cytochrome_b-561)
is_a: GO:0016622 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor

[Term]
id: GO:0008806
name: carboxymethylenebutenolidase activity
namespace: molecular_function
alt_id: GO:0018735
def: "Catalysis of the reaction: 4-carboxymethylenebut-2-en-4-olide + H2O = 4 oxohex-2-enedioate." [EC:3.1.1.45]
subset: gosubset_prok
synonym: "4-carboxymethylenebut-2-en-4-olide lactonohydrolase activity" EXACT [EC:3.1.1.45]
synonym: "carboxymethylene butenolide hydrolase activity" EXACT [EC:3.1.1.45]
synonym: "dienelactone hydrolase activity" EXACT [EC:3.1.1.45]
synonym: "maleylacetate enol-lactonase activity" EXACT [EC:3.1.1.45]
xref: EC:3.1.1.45
xref: MetaCyc:CARBOXYMETHYLENEBUTENOLIDASE-RXN
xref: RHEA:12375
xref: UM-BBD_enzymeID:e0066
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0008807
name: carboxyvinyl-carboxyphosphonate phosphorylmutase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-carboxyvinyl carboxyphosphonate = 3-(hydrohydroxyphosphoryl)pyruvate + CO2." [EC:2.7.8.23]
subset: gosubset_prok
synonym: "1-carboxyvinyl carboxyphosphonate phosphorylmutase (decarboxylating)" EXACT [EC:2.7.8.23]
synonym: "carboxyphosphonoenolpyruvate phosphonomutase activity" EXACT [EC:2.7.8.23]
synonym: "CPEP phosphonomutase activity" EXACT [EC:2.7.8.23]
xref: EC:2.7.8.23
xref: MetaCyc:2.7.8.23-RXN
xref: RHEA:14048
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0008808
name: cardiolipin synthase activity
namespace: molecular_function
alt_id: GO:0043788
def: "Catalysis of the reaction: phosphatidylglycerol + phosphatidylglycerol = diphosphatidylglycerol (cardiolipin) + glycerol." [GOC:jl]
subset: gosubset_prok
synonym: "cardiolipin synthase 2 activity" RELATED []
synonym: "cardiolipin synthetase 2 activity" RELATED []
synonym: "cardiolipin synthetase activity" BROAD []
synonym: "diphosphatidylglycerol synthase activity" EXACT []
xref: EC:2.7.8.-
xref: MetaCyc:CARDIOLIPSYN-RXN
xref: RHEA:31454
is_a: GO:0030572 ! phosphatidyltransferase activity

[Term]
id: GO:0008809
name: carnitine racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-carnitine = L-carnitine." [MetaCyc:CARNRACE-RXN]
xref: EC:5.1.-.-
xref: MetaCyc:CARNRACE-RXN
is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives

[Term]
id: GO:0008810
name: cellulase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans." [EC:3.2.1.4]
subset: gosubset_prok
synonym: "1,4-(1,3;1,4)-beta-D-glucan 4-glucanohydrolase activity" EXACT [EC:3.2.1.4]
synonym: "9.5 cellulase activity" EXACT [EC:3.2.1.4]
synonym: "alkali cellulase activity" NARROW [EC:3.2.1.4]
synonym: "avicelase activity" RELATED [EC:3.2.1.4]
synonym: "beta-1,4-endoglucan hydrolase activity" BROAD [EC:3.2.1.4]
synonym: "beta-1,4-glucanase activity" BROAD [EC:3.2.1.4]
synonym: "carboxymethyl cellulase activity" NARROW [EC:3.2.1.4]
synonym: "celluase A" RELATED [EC:3.2.1.4]
synonym: "celludextrinase activity" EXACT [EC:3.2.1.4]
synonym: "cellulase A 3" RELATED [EC:3.2.1.4]
synonym: "cellulosin AP" RELATED [EC:3.2.1.4]
synonym: "endo-1,4-beta-D-glucanase activity" BROAD [EC:3.2.1.4]
synonym: "endo-1,4-beta-D-glucanohydrolase activity" BROAD [EC:3.2.1.4]
synonym: "endo-1,4-beta-glucanase activity" BROAD [EC:3.2.1.4]
synonym: "endoglucanase activity" BROAD [EC:3.2.1.4]
synonym: "endoglucanase D" RELATED [EC:3.2.1.4]
synonym: "pancellase SS" RELATED [EC:3.2.1.4]
xref: EC:3.2.1.4
xref: MetaCyc:RXN-2043
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0008811
name: chloramphenicol O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: chloramphenicol + acetyl-CoA = chloramphenicol 3-acetate + CoA." [EC:2.3.1.28, RHEA:18424]
subset: gosubset_prok
synonym: "acetyl-CoA:chloramphenicol 3-O-acetyltransferase activity" EXACT [EC:2.3.1.28]
synonym: "CAT I" RELATED [EC:2.3.1.28]
synonym: "CAT II" RELATED [EC:2.3.1.28]
synonym: "CAT III" RELATED [EC:2.3.1.28]
synonym: "chloramphenicol acetylase activity" EXACT [EC:2.3.1.28]
synonym: "chloramphenicol acetyltransferase activity" EXACT [EC:2.3.1.28]
synonym: "chloramphenicol transacetylase activity" EXACT [EC:2.3.1.28]
xref: EC:2.3.1.28
xref: KEGG:R03065
xref: MetaCyc:CHLORAMPHENICOL-O-ACETYLTRANSFERASE-RXN
xref: RHEA:18424
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0008812
name: choline dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde." [EC:1.1.99.1, RHEA:17436]
subset: gosubset_prok
synonym: "choline oxidase activity" BROAD [EC:1.1.99.1]
synonym: "choline-cytochrome c reductase activity" RELATED [EC:1.1.99.1]
synonym: "choline:(acceptor) 1-oxidoreductase activity" EXACT [EC:1.1.99.1]
synonym: "choline:(acceptor) oxidoreductase activity" EXACT [EC:1.1.99.1]
synonym: "choline:acceptor 1-oxidoreductase activity" EXACT [EC:1.1.99.1]
xref: EC:1.1.99.1
xref: KEGG:R01025
xref: MetaCyc:CHD-RXN
xref: RHEA:17436
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0008813
name: chorismate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: chorismate = 4-hydroxybenzoate + pyruvate." [EC:4.1.3.40, RHEA:16508]
subset: gosubset_prok
synonym: "4-hydroxybenzoate synthetase activity" EXACT []
synonym: "chorismate pyruvate lyase activity" EXACT []
synonym: "chorismate pyruvate-lyase (4-hydroxybenzoate-forming) activity" EXACT [EC:4.1.3.40]
synonym: "CL" RELATED [EC:4.1.3.40]
synonym: "CPL" RELATED [EC:4.1.3.40]
synonym: "UbiC" RELATED [EC:4.1.3.40]
xref: EC:4.1.3.40
xref: KEGG:R01302
xref: MetaCyc:CHORPYRLY-RXN
xref: RHEA:16508
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0008814
name: citrate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + citrate = acetate + (3S)-citryl-CoA." [EC:2.8.3.10]
subset: gosubset_prok
synonym: "acetyl-CoA:citrate CoA-transferase activity" EXACT [EC:2.8.3.10]
xref: EC:2.8.3.10
xref: MetaCyc:CITTRANS-RXN
xref: RHEA:19408
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0008815
name: citrate (pro-3S)-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: citrate = acetate + oxaloacetate." [EC:4.1.3.6, RHEA:10763]
subset: gosubset_prok
synonym: "citrase activity" EXACT [EC:4.1.3.6]
synonym: "citratase activity" EXACT [EC:4.1.3.6]
synonym: "citrate aldolase activity" EXACT [EC:4.1.3.6]
synonym: "citrate lyase activity" EXACT []
synonym: "citrate oxaloacetate-lyase [(pro-3S)-CH2COO-->acetate]" RELATED [EC:4.1.3.6]
synonym: "citrate oxaloacetate-lyase activity" EXACT [EC:4.1.3.6]
synonym: "citric aldolase activity" EXACT [EC:4.1.3.6]
synonym: "citridesmolase activity" EXACT [EC:4.1.3.6]
synonym: "citritase activity" EXACT [EC:4.1.3.6]
xref: EC:4.1.3.6
xref: KEGG:R00362
xref: MetaCyc:CITLY-RXN
xref: RHEA:10763
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0008816
name: citryl-CoA lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3S)-citryl-CoA = acetyl-CoA + oxaloacetate." [EC:4.1.3.34]
subset: gosubset_prok
synonym: "(3S)-citryl-CoA oxaloacetate-lyase (acetyl-CoA-forming)" EXACT [EC:4.1.3.34]
synonym: "(3S)-citryl-CoA oxaloacetate-lyase activity" EXACT [EC:4.1.3.34]
xref: EC:4.1.3.34
xref: MetaCyc:CITRYLY-RXN
xref: RHEA:20815
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0008817
name: cob(I)yrinic acid a,c-diamide adenosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + cob(I)alamin + H2O = phosphate + diphosphate + adenosylcobalamin." [EC:2.5.1.17]
subset: gosubset_prok
synonym: "aquacob(I)alamin adenosyltransferase activity" EXACT [EC:2.5.1.17]
synonym: "aquocob(I)alamin vitamin B12s adenosyltransferase activity" RELATED [EC:2.5.1.17]
synonym: "ATP:cob(I)alamin Co-beta-adenosyltransferase activity" EXACT [EC:2.5.1.17]
synonym: "ATP:cob(I)alamin cobeta-adenosyltransferase activity" EXACT [EC:2.5.1.17]
synonym: "ATP:cob(I)yrinic acid-a,c-diamide cobeta-adenosyltransferase activity" EXACT [EC:2.5.1.17]
synonym: "ATP:corrinoid adenosyltransferase activity" EXACT [EC:2.5.1.17]
synonym: "cob(I)alamin adenosyltransferase activity" EXACT []
synonym: "CobA" RELATED [EC:2.5.1.17]
synonym: "vitamin B12s adenosyltransferase activity" EXACT [EC:2.5.1.17]
xref: EC:2.5.1.17
xref: MetaCyc:COBALADENOSYLTRANS-RXN
xref: RHEA:14728
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0008818
name: cobalamin 5'-phosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: adenosylcobinamide-GDP + alpha-ribazole-5'-phosphate = adenosylcobalamin-5'-phosphate + GMP." [MetaCyc:COBALAMIN5PSYN-RXN]
subset: gosubset_prok
xref: MetaCyc:COBALAMIN5PSYN-RXN
xref: RHEA:23563
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0008819
name: cobinamide kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: cobinamide + ATP = cobinamide phosphate + ADP. This reaction is the phosphorylation of the hydroxyl group of the 1-amino-2-propanol residue of cobinamide, in the presence of ATP, to form cobinamide phosphate." [http://www.mblab.gla.ac.uk/, PMID:1655696]
subset: gosubset_prok
xref: EC:2.7.1.-
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0008820
name: cobinamide phosphate guanylyltransferase activity
namespace: molecular_function
alt_id: GO:0043753
def: "Catalysis of the reaction: adenosylcobinamide phosphate + GTP + 2 H(+) = adenosylcobinamide-GDP + diphosphate." [EC:2.7.7.62, RHEA:22715]
subset: gosubset_prok
synonym: "adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase" BROAD []
synonym: "adenosylcobinamide-phosphate guanylyltransferase activity" EXACT []
synonym: "AdoCbi kinase/AdoCbi-phosphate guanylyltransferase" BROAD []
synonym: "CobU" RELATED []
synonym: "GTP:adenosylcobinamide-phosphate guanylyltransferase activity" EXACT []
synonym: "GTP:cobinamide phosphate guanylyltransferase activity" EXACT []
xref: EC:2.7.7.62
xref: KEGG:R05222
xref: MetaCyc:COBINPGUANYLYLTRANS-RXN
xref: RHEA:22715
is_a: GO:0070568 ! guanylyltransferase activity

[Term]
id: GO:0008821
name: crossover junction endodeoxyribonuclease activity
namespace: molecular_function
alt_id: GO:0008844
def: "Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction)." [EC:3.1.22.4]
synonym: "crossover junction endoribonuclease activity" EXACT []
synonym: "cruciform-cutting endonuclease activity" EXACT [EC:3.1.22.-]
synonym: "endo X3" RELATED [EC:3.1.22.4]
synonym: "Endo X3 activity" NARROW [EC:3.1.22.-]
synonym: "endodeoxyribonuclease RUS activity" EXACT []
synonym: "endonuclease RuvC activity" NARROW [EC:3.1.22.-]
synonym: "endonuclease VII activity" NARROW [EC:3.1.22.-]
synonym: "endonuclease X3 activity" NARROW [EC:3.1.22.-]
synonym: "Hje endonuclease activity" EXACT [EC:3.1.22.-]
synonym: "Holliday junction endonuclease CCE1 activity" NARROW [EC:3.1.22.-]
synonym: "Holliday junction nuclease activity" EXACT [EC:3.1.22.-]
synonym: "Holliday junction resolvase activity" NARROW [EC:3.1.22.-]
synonym: "Holliday junction-cleaving endonuclease activity" EXACT [EC:3.1.22.-]
synonym: "Holliday junction-resolving endoribonuclease activity" NARROW [EC:3.1.22.-]
synonym: "resolving enzyme CCE1 activity" NARROW [EC:3.1.22.-]
synonym: "RusA endonuclease activity" NARROW [EC:3.1.22.-]
synonym: "RusA holliday junction resolvase" NARROW [EC:3.1.22.4]
synonym: "RusA Holliday junction resolvase activity" NARROW [EC:3.1.22.-]
synonym: "RuvC endonuclease activity" NARROW [EC:3.1.22.-]
synonym: "SpCCe1 holliday junction resolvase" NARROW [EC:3.1.22.4]
synonym: "SpCCe1 Holliday junction resolvase activity" NARROW [EC:3.1.22.-]
xref: EC:3.1.22.4
xref: MetaCyc:3.1.22.4-RXN
is_a: GO:0016889 ! endodeoxyribonuclease activity, producing 3'-phosphomonoesters

[Term]
id: GO:0008822
name: obsolete crotonobetaine/carnitine-CoA ligase activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a bifunctional gene product.
synonym: "crotonobetaine/carnitine-CoA ligase activity" EXACT []
is_obsolete: true
consider: GO:0051108
consider: GO:0051109

[Term]
id: GO:0008823
name: cupric reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: Cu+ + NAD+ + H+ = Cu2+ + NADH." [PMID:10510271]
xref: EC:1.16.1.-
xref: MetaCyc:R170-RXN
is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor

[Term]
id: GO:0008824
name: cyanate hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyanate + H2O = carbamate." [EC:4.2.1.104]
comment: Note that this function was formerly EC:4.3.99.1.
subset: gosubset_prok
synonym: "carbamate hydro-lyase activity" EXACT [EC:4.2.1.104]
synonym: "cyanase activity" EXACT []
synonym: "cyanate aminohydrolase activity" EXACT [EC:4.2.1.104]
synonym: "cyanate C-N-lyase activity" EXACT [EC:4.2.1.104]
synonym: "cyanate hydrolase activity" EXACT [EC:4.2.1.104]
synonym: "cyanate lyase activity" EXACT []
xref: EC:4.2.1.104
xref: MetaCyc:R524-RXN
xref: RHEA:24653
xref: UM-BBD_reactionID:r0608
is_a: GO:0016840 ! carbon-nitrogen lyase activity

[Term]
id: GO:0008825
name: cyclopropane-fatty-acyl-phospholipid synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid." [EC:2.1.1.79]
subset: gosubset_prok
synonym: "CFA synthase activity" EXACT [EC:2.1.1.79]
synonym: "cyclopropane fatty acid synthase activity" EXACT [EC:2.1.1.79]
synonym: "cyclopropane fatty acid synthetase activity" EXACT [EC:2.1.1.79]
synonym: "cyclopropane synthase activity" EXACT [EC:2.1.1.79]
synonym: "cyclopropane synthetase activity" BROAD [EC:2.1.1.79]
synonym: "S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (cyclizing)" EXACT [EC:2.1.1.79]
synonym: "unsaturated-phospholipid methyltransferase activity" BROAD [EC:2.1.1.79]
xref: EC:2.1.1.79
xref: MetaCyc:2.1.1.79-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0008826
name: cysteine sulfinate desulfinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-sulfinoalanine = L-alanine + sulfite." [MetaCyc:RXN0-279]
synonym: "cysteine sulphinate desulphinase activity" EXACT []
xref: EC:4.4.1.-
xref: MetaCyc:RXN0-279
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0008827
name: cytochrome o ubiquinol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: ubiquinol + O2 = ubiquinone + 2 H2O; cytochrome O is the electron acceptor." [GOC:mah, MetaCyc:CYT-UBIQUINOL-OXID-RXN]
subset: gosubset_prok
xref: EC:1.10.3.-
is_a: GO:0015002 ! heme-copper terminal oxidase activity
is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor

[Term]
id: GO:0008828
name: dATP pyrophosphohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: deoxy-ATP + H2O = dAMP + diphosphate." [MetaCyc:RXN0-384]
subset: gosubset_prok
xref: EC:3.6.1.-
xref: MetaCyc:RXN0-384
is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity

[Term]
id: GO:0008829
name: dCTP deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: dCTP + H2O = dUTP + NH3." [EC:3.5.4.13]
subset: gosubset_prok
synonym: "5-methyl-dCTP deaminase activity" EXACT [EC:3.5.4.13]
synonym: "dCTP aminohydrolase activity" EXACT [EC:3.5.4.13]
synonym: "deoxycytidine triphosphate deaminase activity" EXACT [EC:3.5.4.13]
xref: EC:3.5.4.13
xref: MetaCyc:DCTP-DEAM-RXN
xref: Reactome:REACT_9435 "Deamination of C residues during synthesis of HIV-1 reverse transcript minus-strand, Homo sapiens"
xref: RHEA:22683
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0008830
name: dTDP-4-dehydrorhamnose 3,5-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-L-mannose." [EC:5.1.3.13, RHEA:16972]
subset: gosubset_prok
synonym: "dTDP-4-dehydro-6-deoxy-D-glucose 3,5-epimerase activity" EXACT [EC:5.1.3.13]
synonym: "dTDP-4-keto-6-deoxyglucose 3,5-epimerase activity" EXACT [EC:5.1.3.13]
synonym: "dTDP-L-rhamnose synthetase activity" EXACT [EC:5.1.3.13]
synonym: "TDP-4-keto-L-rhamnose-3,5-epimerase activity" EXACT [EC:5.1.3.13]
synonym: "TDP-4-ketorhamnose 3,5-epimerase activity" EXACT [EC:5.1.3.13]
synonym: "thymidine diphospho-4-ketorhamnose 3,5-epimerase activity" RELATED [EC:5.1.3.13]
xref: EC:5.1.3.13
xref: KEGG:R06514
xref: MetaCyc:DTDPDEHYDRHAMEPIM-RXN
xref: RHEA:16972
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0008831
name: dTDP-4-dehydrorhamnose reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP(+) = dTDP-4-dehydro-6-deoxy-L-mannose + H(+) + NADPH." [EC:1.1.1.133, RHEA:21799]
subset: gosubset_prok
synonym: "dTDP-4-keto-L-rhamnose reductase activity" EXACT [EC:1.1.1.133]
synonym: "dTDP-4-ketorhamnose reductase activity" EXACT [EC:1.1.1.133]
synonym: "dTDP-6-deoxy-L-mannose dehydrogenase activity" EXACT [EC:1.1.1.133]
synonym: "dTDP-6-deoxy-L-mannose:NADP+ 4-oxidoreductase activity" EXACT [EC:1.1.1.133]
synonym: "reductase, thymidine diphospho-4-ketorhamnose" EXACT [EC:1.1.1.133]
synonym: "TDP-4-keto-rhamnose reductase activity" EXACT [EC:1.1.1.133]
synonym: "thymidine diphospho-4-ketorhamnose reductase activity" EXACT [EC:1.1.1.133]
xref: EC:1.1.1.133
xref: KEGG:R02777
xref: MetaCyc:DTDPDEHYRHAMREDUCT-RXN
xref: RHEA:21799
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008832
name: dGTPase activity
namespace: molecular_function
def: "Catalysis of the reaction: dGTP + H(2)O = 2'-deoxyguanosine + 2 H(+) + triphosphate." [EC:3.1.5.1, RHEA:15196]
subset: gosubset_prok
synonym: "deoxy-GTPase activity" EXACT [EC:3.1.5.1]
synonym: "deoxyguanosine 5-triphosphate triphosphohydrolase activity" EXACT [EC:3.1.5.1]
synonym: "deoxyguanosine triphosphatase activity" EXACT [EC:3.1.5.1]
synonym: "deoxyguanosine triphosphate triphosphohydrolase activity" EXACT [EC:3.1.5.1]
synonym: "deoxyguanosinetriphosphate triphosphohydrolase activity" EXACT []
synonym: "dGTP triphosphohydrolase activity" EXACT [EC:3.1.5.1]
xref: EC:3.1.5.1
xref: KEGG:R01856
xref: MetaCyc:DGTPTRIPHYDRO-RXN
xref: RHEA:15196
is_a: GO:0016793 ! triphosphoric monoester hydrolase activity

[Term]
id: GO:0008833
name: deoxyribonuclease IV (phage-T4-induced) activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage to 5'-phosphooligonucleotide end-products." [EC:3.1.21.2]
subset: gosubset_prok
synonym: "deoxriboendonuclease activity" EXACT [EC:3.1.21.2]
synonym: "deoxyribonuclease IV (phage T4-induced) activity" EXACT [EC:3.1.21.2]
synonym: "DNA-adenine-transferase activity" EXACT [EC:3.1.21.2]
synonym: "E. coli endonuclease IV" RELATED [EC:3.1.21.2]
synonym: "endodeoxyribonuclease IV (phage T(4)-induced) activity" EXACT [EC:3.1.21.2]
synonym: "endodeoxyribonuclease IV (phage T4-induced) activity" EXACT [EC:3.1.21.2]
synonym: "endonuclease II" RELATED [EC:3.1.21.2]
synonym: "endonuclease IV activity" RELATED [EC:3.1.21.2]
synonym: "Escherichia coli endonuclease II" RELATED [EC:3.1.21.2]
synonym: "redoxyendonuclease activity" EXACT [EC:3.1.21.2]
xref: EC:3.1.21.2
xref: MetaCyc:3.1.21.2-RXN
is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0008834
name: di-trans,poly-cis-decaprenylcistransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: di-trans-poly-cis-decaprenyl diphosphate + isopentenyl diphosphate = diphosphate + di-trans-poly-cis-undecaprenyl diphosphate." [EC:2.5.1.31]
subset: gosubset_prok
synonym: "bactoprenyl-diphosphate synthase activity" RELATED [EC:2.5.1.31]
synonym: "di-trans,poly-cis-decaprenyl-diphosphate:isopentenyl-diphosphate undecaprenylcistransferase activity" EXACT [EC:2.5.1.31]
synonym: "di-trans,poly-cis-undecaprenyl-diphosphate synthase activity" EXACT [EC:2.5.1.31]
synonym: "undecaprenyl diphosphate synthase activity" EXACT []
synonym: "undecaprenyl diphosphate synthetase activity" EXACT [EC:2.5.1.31]
synonym: "undecaprenyl pyrophosphate synthase activity" EXACT [EC:2.5.1.31]
synonym: "undecaprenyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.31]
synonym: "undecaprenyl-diphosphate synthase activity" EXACT [EC:2.5.1.31]
synonym: "UPP synthetase activity" EXACT [EC:2.5.1.31]
xref: EC:2.5.1.31
xref: MetaCyc:RXN-8999
xref: RHEA:27551
is_a: GO:0004659 ! prenyltransferase activity

[Term]
id: GO:0008835
name: diaminohydroxyphosphoribosylaminopyrimidine deaminase activity
namespace: molecular_function
alt_id: GO:0008485
def: "Catalysis of the reaction: 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(2)O + H(+) = 5-amino-6-(5-phosphoribosylamino)uracil + NH(4)(+)." [EC:3.5.4.26, RHEA:21871]
subset: gosubset_prok
synonym: "2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate deaminase activity" EXACT []
synonym: "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine 2-aminohydrolase activity" EXACT [EC:3.5.4.26]
synonym: "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine 2-aminohydrolase activity" EXACT [EC:3.5.4.26]
xref: EC:3.5.4.26
xref: KEGG:R03459
xref: MetaCyc:RIBOFLAVINSYNDEAM-RXN
xref: RHEA:21871
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0008836
name: diaminopimelate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: meso-2,6-diaminopimelate + H(+) = L-lysine + CO(2)." [EC:4.1.1.20, RHEA:15104]
subset: gosubset_prok
synonym: "DAP decarboxylase activity" EXACT [EC:4.1.1.20]
synonym: "DAP-decarboxylase activity" EXACT [EC:4.1.1.20]
synonym: "diaminopimelic acid decarboxylase activity" EXACT [EC:4.1.1.20]
synonym: "meso-2,6-diaminoheptanedioate carboxy-lyase (L-lysine-forming)" EXACT [EC:4.1.1.20]
synonym: "meso-2,6-diaminoheptanedioate carboxy-lyase activity" EXACT [EC:4.1.1.20]
synonym: "meso-diaminopimelate decarboxylase activity" EXACT [EC:4.1.1.20]
xref: EC:4.1.1.20
xref: KEGG:R00451
xref: MetaCyc:DIAMINOPIMDECARB-RXN
xref: RHEA:15104
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0008837
name: diaminopimelate epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: LL-2,6-diaminopimelate = meso-2,6-diaminopimelate." [EC:5.1.1.7, RHEA:15396]
subset: gosubset_prok
synonym: "LL-2,6-diaminoheptanedioate 2-epimerase activity" EXACT [EC:5.1.1.7]
xref: EC:5.1.1.7
xref: KEGG:R02735
xref: MetaCyc:DIAMINOPIMEPIM-RXN
xref: RHEA:15396
is_a: GO:0047661 ! amino-acid racemase activity

[Term]
id: GO:0008838
name: diaminopropionate ammonia-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-diaminopropionate + H2O = pyruvate + 2 NH3." [EC:4.3.1.15]
subset: gosubset_prok
synonym: "2,3-diaminopropionate ammonia-lyase (adding H2O; pyruvate-forming)" EXACT [EC:4.3.1.15]
synonym: "2,3-diaminopropionate ammonia-lyase activity" EXACT [EC:4.3.1.15]
synonym: "alpha,beta-diaminopropionate ammonia-lyase activity" EXACT [EC:4.3.1.15]
synonym: "diaminopropionatase activity" EXACT [EC:4.3.1.15]
xref: EC:4.3.1.15
xref: MetaCyc:4.3.1.15-RXN
xref: RHEA:22087
is_a: GO:0016841 ! ammonia-lyase activity

[Term]
id: GO:0008839
name: 4-hydroxy-tetrahydrodipicolinate reductase
namespace: molecular_function
def: "Catalysis of the reaction: (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+." [EC:1.17.1.8]
subset: gosubset_prok
synonym: "2,3,4,5-tetrahydrodipicolinate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.3.1.26]
synonym: "dihydrodipicolinate reductase activity" EXACT []
synonym: "dihydrodipicolinic acid reductase activity" EXACT [EC:1.3.1.26]
xref: EC:1.17.1.8
xref: MetaCyc:DIHYDROPICRED-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008840
name: 4-hydroxy-tetrahydrodipicolinate synthase
namespace: molecular_function
def: "Catalysis of the reaction: pyruvate + L-aspartate-4-semialdehyde = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O." [EC:4.3.3.7, RHEA:14848]
subset: gosubset_prok
synonym: "DHDPS activity" EXACT [EC:4.2.1.52]
synonym: "dihydrodipicolinate synthase activity" EXACT []
synonym: "dihydrodipicolinate synthetase activity" EXACT [EC:4.2.1.52]
synonym: "dihydrodipicolinic acid synthase activity" EXACT [EC:4.2.1.52]
synonym: "dihydropicolinate synthetase activity" EXACT [EC:4.2.1.52]
synonym: "L-aspartate-4-semialdehyde hydro-lyase (adding pyruvate and cyclizing)" EXACT [EC:4.2.1.52]
synonym: "L-aspartate-4-semialdehyde hydro-lyase [adding pyruvate and cyclizing; (S)-2,3-dihydropyridine-2,6-dicarboxylate-forming]" RELATED [EC:4.2.1.52]
xref: EC:4.3.3.7
xref: KEGG:R02292
xref: MetaCyc:DIHYDRODIPICSYN-RXN
xref: RHEA:14848
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0008841
name: dihydrofolate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + dihydropterate + L-glutamate = ADP + phosphate + dihydrofolate." [EC:6.3.2.12]
subset: gosubset_prok
synonym: "7,8-dihydrofolate synthetase activity" EXACT [EC:6.3.2.12]
synonym: "7,8-dihydropteroate:L-glutamate ligase (ADP) activity" EXACT [EC:6.3.2.12]
synonym: "7,8-dihydropteroate:L-glutamate ligase (ADP-forming)" EXACT [EC:6.3.2.12]
synonym: "DHFS activity" EXACT [EC:6.3.2.12]
synonym: "dihydrofolate synthetase activity" EXACT [EC:6.3.2.12]
synonym: "dihydrofolate synthetase-folylpolyglutamate synthetase activity" EXACT [EC:6.3.2.12]
synonym: "dihydropteroate:L-glutamate ligase (ADP-forming) activity" EXACT [EC:6.3.2.12]
synonym: "FHFS activity" EXACT [EC:6.3.2.12]
synonym: "FHFS/FPGS activity" EXACT [EC:6.3.2.12]
synonym: "folylpoly-(gamma-glutamate) synthetase-dihydrofolate synthase activity" EXACT [EC:6.3.2.12]
synonym: "H(2)-folate synthetase activity" EXACT [EC:6.3.2.12]
synonym: "H2-folate synthetase activity" EXACT [EC:6.3.2.12]
xref: EC:6.3.2.12
xref: MetaCyc:DIHYDROFOLATESYNTH-RXN
xref: RHEA:23587
is_a: GO:0016881 ! acid-amino acid ligase activity
relationship: part_of GO:0006761 ! dihydrofolate biosynthetic process

[Term]
id: GO:0008842
name: diphosphate-purine nucleoside kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: diphosphate + a purine nucleoside = monophosphate + a purine mononucleotide." [EC:2.7.1.143]
synonym: "diphosphate-dependent nucleoside kinase activity" EXACT [EC:2.7.1.143]
synonym: "diphosphate:purine nucleoside phosphotransferase activity" EXACT [EC:2.7.1.143]
synonym: "pyrophosphate-dependent nucleoside kinase activity" EXACT [EC:2.7.1.143]
synonym: "pyrophosphate-purine nucleoside kinase activity" EXACT [EC:2.7.1.143]
xref: EC:2.7.1.143
xref: MetaCyc:2.7.1.143-RXN
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019206 ! nucleoside kinase activity

[Term]
id: GO:0008843
name: endochitinase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of nonterminal (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. Typically, endochitinases cleave randomly within the chitin chain." [EC:3.2.1.-, GOC:bf, GOC:kah, GOC:pde, PMID:11468293]
is_a: GO:0004568 ! chitinase activity

[Term]
id: GO:0008845
name: obsolete endonuclease VIII activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [PMID:12713806]
comment: This term was made obsolete because it represents a gene product.
synonym: "endonuclease VIII activity" EXACT []
is_obsolete: true
consider: GO:0000703
consider: GO:0003684
consider: GO:0003906
consider: GO:0004519
consider: GO:0008081
consider: GO:0019104

[Term]
id: GO:0008846
name: obsolete endopeptidase La activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of large proteins such as globin, casein and denatured serum albumin, in presence of ATP." [EC:3.4.21.53]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "ATP-dependent lon proteinase" NARROW [EC:3.4.21.53]
synonym: "ATP-dependent protease La activity" EXACT [EC:3.4.21.53]
synonym: "ATP-dependent serine proteinase activity" RELATED [EC:3.4.21.53]
synonym: "endopeptidase La activity" EXACT []
synonym: "Escherichia coli proteinase La" RELATED [EC:3.4.21.53]
synonym: "Escherichia coli serine proteinase La" RELATED [EC:3.4.21.53]
synonym: "gene lon protease activity" EXACT [EC:3.4.21.53]
synonym: "gene lon proteins" RELATED [EC:3.4.21.53]
synonym: "lon proteinase" NARROW [EC:3.4.21.53]
synonym: "PIM1 protease activity" EXACT [EC:3.4.21.53]
synonym: "PIM1 proteinase activity" EXACT [EC:3.4.21.53]
synonym: "protease La" RELATED [EC:3.4.21.53]
synonym: "proteinase La" RELATED [EC:3.4.21.53]
synonym: "serine protease La" RELATED [EC:3.4.21.53]
xref: EC:3.4.21.53
xref: MetaCyc:3.4.21.53-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0008847
name: Enterobacter ribonuclease activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates." [EC:3.1.27.6]
subset: gosubset_prok
synonym: "enterobacter ribonuclease activity" EXACT [EC:3.1.27.6]
synonym: "Enterobacter RNase activity" EXACT []
xref: EC:3.1.27.6
xref: MetaCyc:3.1.27.6-RXN
is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters

[Term]
id: GO:0008848
name: obsolete enterobactin synthetase
namespace: molecular_function
alt_id: GO:0008850
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a process rather than a function.
synonym: "enterobactin synthetase" EXACT []
synonym: "enterochelin synthetase activity" EXACT []
synonym: "nonribosomal peptide synthetase" RELATED []
is_obsolete: true
replaced_by: GO:0009239

[Term]
id: GO:0008849
name: enterochelin esterase activity
namespace: molecular_function
def: "Catalysis of the reaction: enterobactin + 3 H2O = 3 N-23-dihydroxybenzoyl-L-serine + 3 H+." [MetaCyc:RXN0-1661, PMID:4565531]
synonym: "enterobactin esterase activity" EXACT []
xref: MetaCyc:RXN0-1661
is_a: GO:0016788 ! hydrolase activity, acting on ester bonds

[Term]
id: GO:0008851
name: ethanolamine ammonia-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: ethanolamine = acetaldehyde + NH3." [EC:4.3.1.7]
subset: gosubset_prok
synonym: "ethanolamine ammonia-lyase (acetaldehyde-forming) activity" EXACT [EC:4.3.1.7]
synonym: "ethanolamine deaminase activity" EXACT [EC:4.3.1.7]
xref: EC:4.3.1.7
xref: MetaCyc:ETHAMLY-RXN
xref: RHEA:15316
is_a: GO:0016841 ! ammonia-lyase activity

[Term]
id: GO:0008852
name: exodeoxyribonuclease I activity
namespace: molecular_function
def: "Catalysis of the degradation of single-stranded DNA. It acts progressively in a 3' to 5' direction, releasing 5'-phosphomononucleotides." [EC:3.1.11.1]
subset: gosubset_prok
synonym: "E. coli exonuclease I" RELATED [EC:3.1.11.1]
synonym: "E. coli exonuclease I activity" NARROW [EC:3.1.11.1]
synonym: "Escherichia coli exonuclease I" RELATED [EC:3.1.11.1]
synonym: "exonuclease I activity" RELATED [EC:3.1.11.1]
xref: EC:3.1.11.1
xref: MetaCyc:3.1.11.1-RXN
is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0008853
name: exodeoxyribonuclease III activity
namespace: molecular_function
def: "Catalysis of the degradation of double-stranded DNA. It acts progressively in a 3' to 5' direction, releasing 5'-phosphomononucleotides." [EC:3.1.11.2]
subset: gosubset_prok
synonym: "E. coli exonuclease III" RELATED [EC:3.1.11.2]
synonym: "E. coli exonuclease III activity" NARROW [EC:3.1.11.2]
synonym: "endoribonuclease III" RELATED [EC:3.1.11.2]
synonym: "Escherichia coli exonuclease III" RELATED [EC:3.1.11.2]
synonym: "exonuclease III activity" EXACT [EC:3.1.11.2]
xref: EC:3.1.11.2
xref: MetaCyc:3.1.11.2-RXN
is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0008854
name: exodeoxyribonuclease V activity
namespace: molecular_function
def: "Catalysis of the exonucleolytic cleavage (in the presence of ATP) in either 5' to 3' or 3' to 5' direction to yield 5'-phosphooligonucleotides." [EC:3.1.11.5]
subset: gosubset_prok
synonym: "E. coli exonuclease V" RELATED [EC:3.1.11.5]
synonym: "E. coli exonuclease V activity" NARROW [EC:3.1.11.5]
synonym: "Escherichia coli exonuclease V" RELATED [EC:3.1.11.5]
synonym: "exonuclease V activity" EXACT [EC:3.1.11.5]
synonym: "gene recBC DNase activity" EXACT [EC:3.1.11.5]
synonym: "gene recBC endoenzyme" RELATED [EC:3.1.11.5]
synonym: "gene recBCD enzymes" RELATED [EC:3.1.11.5]
synonym: "RecBC deoxyribonuclease activity" EXACT [EC:3.1.11.5]
xref: EC:3.1.11.5
xref: MetaCyc:3.1.11.5-RXN
is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0008855
name: exodeoxyribonuclease VII activity
namespace: molecular_function
def: "Catalysis of the exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield 5'-phosphomononucleotides." [EC:3.1.11.6]
subset: gosubset_prok
synonym: "E. coli exonuclease VII" RELATED [EC:3.1.11.6]
synonym: "E. coli exonuclease VII activity" NARROW [EC:3.1.11.6]
synonym: "endodeoxyribonuclease VII" RELATED [EC:3.1.11.6]
synonym: "Escherichia coli exonuclease VII" RELATED [EC:3.1.11.6]
synonym: "exonuclease VII activity" EXACT [EC:3.1.11.6]
xref: EC:3.1.11.6
xref: MetaCyc:3.1.11.6-RXN
is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0008856
name: exodeoxyribonuclease X activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of supercoiled plasma DNA to linear DNA duplexes." [EC:3.1.22.5]
synonym: "deoxyribonuclease X activity" EXACT [EC:3.1.22.5]
synonym: "Escherichia coli endodeoxyribonuclease activity" RELATED [EC:3.1.22.5]
synonym: "Escherichia coli endodeoxyribonuclease X activity" NARROW [EC:3.1.22.5]
xref: EC:3.1.11.-
xref: MetaCyc:3.1.22.5-RXN
is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0008859
name: exoribonuclease II activity
namespace: molecular_function
def: "Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction." [EC:3.1.13.1, ISBN:0198547684]
subset: gosubset_prok
synonym: "5'-exoribonuclease activity" EXACT [EC:3.1.13.1]
synonym: "BN ribonuclease activity" EXACT [EC:3.1.13.1]
synonym: "Escherichia coli exo-RNase II" RELATED [EC:3.1.13.1]
synonym: "ribonuclease II activity" EXACT [EC:3.1.13.1]
synonym: "ribonuclease Q" RELATED [EC:3.1.13.1]
synonym: "RNase II" RELATED [EC:3.1.13.1]
synonym: "RNase II activity" EXACT []
xref: EC:3.1.13.1
xref: MetaCyc:3.1.13.1-RXN
is_a: GO:0008408 ! 3'-5' exonuclease activity
is_a: GO:0016896 ! exoribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0008860
name: ferredoxin-NAD+ reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: reduced ferredoxin + NAD+ = oxidized ferredoxin + NADH + H+." [EC:1.18.1.3]
subset: gosubset_prok
synonym: "ferredoxin-linked NAD reductase activity" EXACT [EC:1.18.1.3]
synonym: "ferredoxin-NAD reductase activity" EXACT []
synonym: "ferredoxin-nicotinamide adenine dinucleotide reductase activity" EXACT [EC:1.18.1.3]
synonym: "ferredoxin:NAD+ oxidoreductase activity" EXACT [EC:1.18.1.3]
synonym: "NAD-ferredoxin reductase activity" EXACT [EC:1.18.1.3]
synonym: "NADH flavodoxin oxidoreductase activity" EXACT [EC:1.18.1.3]
synonym: "NADH-ferredoxin oxidoreductase activity" EXACT [EC:1.18.1.3]
synonym: "NADH-ferredoxin reductase activity" EXACT [EC:1.18.1.3]
synonym: "NADH-ferredoxinNAP reductase (component of naphthalene dioxygenase multicomponent enzyme system)" EXACT [EC:1.18.1.3]
synonym: "NADH-ferredoxinTOL reductase (component of toluene dioxygenase)" EXACT [EC:1.18.1.3]
synonym: "NADH2-ferredoxin oxidoreductase activity" EXACT [EC:1.18.1.3]
synonym: "reductase, reduced nicotinamide adenine dinucleotide-ferredoxin" EXACT [EC:1.18.1.3]
xref: EC:1.18.1.3
xref: MetaCyc:FERREDOXIN--NAD+-REDUCTASE-RXN
is_a: GO:0016731 ! oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor

[Term]
id: GO:0008861
name: formate C-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + formate = CoA + pyruvate." [EC:2.3.1.54]
subset: gosubset_prok
synonym: "acetyl-CoA:formate C-acetyltransferase activity" EXACT [EC:2.3.1.54]
synonym: "formate acetyltransferase activity" EXACT [EC:2.3.1.54]
synonym: "PFL" EXACT []
synonym: "pyruvate formate-lyase activity" EXACT [EC:2.3.1.54]
synonym: "pyruvate formate:lyase activity" EXACT []
synonym: "pyruvic formate-lyase activity" EXACT [EC:2.3.1.54]
xref: EC:2.3.1.54
xref: MetaCyc:PYRUVFORMLY-RXN
xref: RHEA:11847
is_a: GO:0016453 ! C-acetyltransferase activity

[Term]
id: GO:0008863
name: formate dehydrogenase (NAD+) activity
namespace: molecular_function
alt_id: GO:0018476
def: "Catalysis of the reaction: formate + NAD(+) = CO(2) + NADH." [EC:1.2.1.2, RHEA:15988]
subset: gosubset_prok
synonym: "FDH I" RELATED [EC:1.2.1.2]
synonym: "FDH II" RELATED [EC:1.2.1.2]
synonym: "formate benzyl-viologen oxidoreductase" EXACT [EC:1.2.1.2]
synonym: "formate dehydrogenase (NAD)" EXACT [EC:1.2.1.2]
synonym: "formate hydrogenlyase" EXACT [EC:1.2.1.2]
synonym: "formate-NAD oxidoreductase" EXACT [EC:1.2.1.2]
synonym: "formate:NAD+ oxidoreductase" EXACT [EC:1.2.1.2]
synonym: "formic acid dehydrogenase" EXACT [EC:1.2.1.2]
synonym: "formic hydrogen-lyase" EXACT [EC:1.2.1.2]
synonym: "N-FDH" RELATED [EC:1.2.1.2]
synonym: "NAD-dependent formate dehydrogenase" EXACT [EC:1.2.1.2]
synonym: "NAD-formate dehydrogenase" EXACT [EC:1.2.1.2]
synonym: "NAD-linked formate dehydrogenase" EXACT [EC:1.2.1.2]
xref: EC:1.2.1.2
xref: KEGG:R00519
xref: MetaCyc:1.2.1.2-RXN
xref: MetaCyc:FORMATEDEHYDROG-RXN
xref: RHEA:15988
xref: UM-BBD_reactionID:r0103
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008864
name: formyltetrahydrofolate deformylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 10-formyltetrahydrofolate + H(2)O = (6S)-5,6,7,8-tetrahydrofolate + formate + H(+)." [EC:3.5.1.10, RHEA:19836]
subset: gosubset_prok
synonym: "10-formyltetrahydrofolate amidohydrolase activity" EXACT [EC:3.5.1.10]
synonym: "formyl-FH(4) hydrolase activity" EXACT [EC:3.5.1.10]
synonym: "formyltetrahydrofolate hydrolase activity" EXACT [EC:3.5.1.10]
xref: EC:3.5.1.10
xref: KEGG:R00944
xref: MetaCyc:FORMYLTHFDEFORMYL-RXN
xref: RHEA:19836
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0008865
name: fructokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 6-phosphate." [EC:2.7.1.4]
subset: gosubset_prok
synonym: "ATP:D-fructose 6-phosphotransferase activity" EXACT [EC:2.7.1.4]
synonym: "D-fructokinase activity" EXACT [EC:2.7.1.4]
synonym: "D-fructose(D-mannose)kinase activity" EXACT [EC:2.7.1.4]
synonym: "fructokinase (phosphorylating)" EXACT [EC:2.7.1.4]
xref: EC:2.7.1.4
xref: MetaCyc:FRUCTOKINASE-RXN
xref: RHEA:16128
is_a: GO:0004396 ! hexokinase activity

[Term]
id: GO:0008866
name: fructuronate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-mannonate + NAD(+) = D-fructuronate + H(+) + NADH." [EC:1.1.1.57, RHEA:15732]
subset: gosubset_prok
synonym: "D-mannonate dehydrogenase activity" EXACT [EC:1.1.1.57]
synonym: "D-mannonate oxidoreductase activity" EXACT [EC:1.1.1.57]
synonym: "D-mannonate:NAD oxidoreductase activity" EXACT [EC:1.1.1.57]
synonym: "D-mannonate:NAD+ 5-oxidoreductase activity" EXACT [EC:1.1.1.57]
synonym: "mannonate oxidoreductase activity" EXACT [EC:1.1.1.57]
synonym: "mannonic dehydrogenase activity" EXACT [EC:1.1.1.57]
xref: EC:1.1.1.57
xref: KEGG:R02454
xref: MetaCyc:MANNONOXIDOREDUCT-RXN
xref: RHEA:15732
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008867
name: galactarate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: galactarate = 5-dehydro-4-deoxy-D-glucarate + H(2)O." [EC:4.2.1.42, RHEA:16008]
subset: gosubset_prok
synonym: "D-galactarate hydro-lyase (5-dehydro-4-deoxy-D-glucarate-forming)" EXACT [EC:4.2.1.42]
synonym: "D-galactarate hydro-lyase activity" EXACT [EC:4.2.1.42]
xref: EC:4.2.1.42
xref: KEGG:R05608
xref: MetaCyc:GALACTARDEHYDRA-RXN
xref: RHEA:16008
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0008868
name: galactitol-1-phosphate 5-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: galactitol-1-phosphate + NAD+ = L-tagatose 6-phosphate + NADH + H+." [EC:1.1.1.251]
subset: gosubset_prok
synonym: "galactitol-1-phosphate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.251]
xref: EC:1.1.1.251
xref: MetaCyc:1.1.1.251-RXN
xref: RHEA:15140
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008869
name: galactonate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H(2)O." [EC:4.2.1.6, RHEA:18652]
subset: gosubset_prok
synonym: "D-galactonate dehydrase activity" EXACT [EC:4.2.1.6]
synonym: "D-galactonate dehydratase activity" EXACT [EC:4.2.1.6]
synonym: "D-galactonate hydro-lyase (2-dehydro-3-deoxy-D-galactonate-forming)" EXACT [EC:4.2.1.6]
synonym: "D-galactonate hydro-lyase activity" EXACT [EC:4.2.1.6]
xref: EC:4.2.1.6
xref: KEGG:R03033
xref: MetaCyc:GALACTONDEHYDRAT-RXN
xref: RHEA:18652
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0008870
name: galactoside O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + a beta-D-galactoside = CoA + a 6-acetyl-beta-D-galactoside." [EC:2.3.1.18]
subset: gosubset_prok
synonym: "acetyl-CoA:beta-D-galactoside 6-acetyltransferase activity" EXACT [EC:2.3.1.18]
synonym: "galactoside acetyltransferase activity" EXACT [EC:2.3.1.18]
synonym: "thiogalactoside acetyltransferase activity" EXACT [EC:2.3.1.18]
synonym: "thiogalactoside transacetylase activity" EXACT [EC:2.3.1.18]
xref: EC:2.3.1.18
xref: MetaCyc:GALACTOACETYLTRAN-RXN
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0008871
name: aminoglycoside 2''-nucleotidyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside triphosphate + aminoglycoside = diphosphate + 2''-nucleotidylaminoglycoside." [EC:2.7.7.46, GOC:cb]
subset: gosubset_prok
synonym: "2''-aminoglycoside nucleotidyltransferase activity" EXACT [EC:2.7.7.46]
synonym: "gentamicin 2''- adenylyltransferase activity" NARROW [EC:2.7.7.46]
synonym: "gentamicin 2''-nucleotidyltransferase activity" NARROW [EC:2.7.7.46]
synonym: "gentamycin 2''-nucleotidyltransferase activity" NARROW [EC:2.7.7.46]
synonym: "NTP:gentamicin 2''-nucleotidyltransferase activity" NARROW [EC:2.7.7.46]
xref: EC:2.7.7.46
xref: MetaCyc:2.7.7.46-RXN
is_a: GO:0034068 ! aminoglycoside nucleotidyltransferase activity

[Term]
id: GO:0008872
name: glucarate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucarate = 5-dehydro-4-deoxy-D-glucarate + H2O." [EC:4.2.1.40]
subset: gosubset_prok
synonym: "D-glucarate dehydratase activity" EXACT [EC:4.2.1.40]
synonym: "D-glucarate hydro-lyase (5-dehydro-4-deoxy-D-glucarate-forming)" EXACT [EC:4.2.1.40]
synonym: "D-glucarate hydro-lyase activity" EXACT [EC:4.2.1.40]
xref: EC:4.2.1.40
xref: MetaCyc:GLUCARDEHYDRA-RXN
xref: RHEA:14576
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0008873
name: gluconate 2-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-gluconate + NADP+ = 2-dehydro-D-gluconate + NADPH + H+." [EC:1.1.1.215]
subset: gosubset_prok
synonym: "2-keto-D-gluconate reductase activity" EXACT [EC:1.1.1.215]
synonym: "2-ketogluconate reductase activity" EXACT [EC:1.1.1.215]
synonym: "D-gluconate:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.215]
xref: EC:1.1.1.215
xref: MetaCyc:1.1.1.215-RXN
xref: RHEA:16656
is_a: GO:0008875 ! gluconate dehydrogenase activity

[Term]
id: GO:0008874
name: gluconate 5-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-gluconate + NADP+ = 5-dehydro-D-gluconate + NADPH + H+." [EC:1.1.1.69]
subset: gosubset_prok
synonym: "5-keto-D-gluconate 5-reductase activity" EXACT [EC:1.1.1.69]
synonym: "5-keto-D-gluconate reductase" EXACT [EC:1.1.1.69]
synonym: "5-ketogluconate 5-reductase activity" EXACT [EC:1.1.1.69]
synonym: "5-ketogluconate reductase activity" EXACT [EC:1.1.1.69]
synonym: "D-gluconate:NAD(P)+ 5-oxidoreductase" EXACT [EC:1.1.1.69]
xref: EC:1.1.1.69
xref: MetaCyc:GLUCONATE-5-DEHYDROGENASE-RXN
is_a: GO:0008875 ! gluconate dehydrogenase activity

[Term]
id: GO:0008875
name: gluconate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-gluconate + NADP+ = dehydro-D-gluconate + NADPH + H+." [EC:1.1.1.215, EC:1.1.1.69]
subset: gosubset_prok
xref: EC:1.1.1.-
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008876
name: quinoprotein glucose dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucose + ubiquinone = D-glucono-1,5-lactone + ubiquinol." [EC:1.1.5.2]
comment: Note that this was EC:1.1.99.17.
subset: gosubset_prok
synonym: "D-glucose:(pyrroloquinoline-quinone) 1-oxidoreductase activity" EXACT [EC:1.1.5.2]
synonym: "D-glucose:ubiquinone oxidoreductase activity" EXACT [EC:1.1.5.2]
synonym: "glucose dehydrogenase (PQQ-dependent) activity" EXACT [EC:1.1.5.2]
synonym: "glucose dehydrogenase (pyrroloquinoline-quinone) activity" EXACT []
synonym: "quinoprotein D-glucose dehydrogenase activity" EXACT [EC:1.1.5.2]
xref: EC:1.1.5.2
xref: MetaCyc:GLUCDEHYDROG-RXN
xref: RHEA:22155
is_a: GO:0004344 ! glucose dehydrogenase activity
is_a: GO:0016901 ! oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor

[Term]
id: GO:0008877
name: glucose-1-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate + H2O = D-glucose + phosphate." [EC:3.1.3.10]
subset: gosubset_prok
synonym: "alpha-D-glucose-1-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.10]
synonym: "D-glucose-1-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.10]
xref: EC:3.1.3.10
xref: KEGG:R00304
xref: MetaCyc:GLUCOSE-1-PHOSPHAT-RXN
xref: RHEA:19936
is_a: GO:0050308 ! sugar-phosphatase activity

[Term]
id: GO:0008878
name: glucose-1-phosphate adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate + ATP = ADP-glucose + diphosphate." [EC:2.7.7.27, RHEA:12123]
subset: gosubset_prok
synonym: "adenosine diphosphate glucose pyrophosphorylase activity" EXACT [EC:2.7.7.27]
synonym: "adenosine diphosphoglucose pyrophosphorylase activity" EXACT [EC:2.7.7.27]
synonym: "ADGase activity" EXACT []
synonym: "ADP glucose pyrophosphorylase activity" EXACT [EC:2.7.7.27]
synonym: "ADP-glucose diphosphorylase activity" EXACT [EC:2.7.7.27]
synonym: "ADP-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.27]
synonym: "ADP-glucose synthase activity" EXACT [EC:2.7.7.27]
synonym: "ADP-glucose synthetase activity" EXACT [EC:2.7.7.27]
synonym: "ADP:alpha-D-glucose-1-phosphate adenylyltransferase activity" EXACT [EC:2.7.7.27]
synonym: "ADPG pyrophosphorylase activity" EXACT []
synonym: "ATP:alpha-D-glucose-1-phosphate adenylyltransferase activity" EXACT [EC:2.7.7.27]
synonym: "ATP:alpha-glucose-1-phosphate adenylyl transferase activity" EXACT []
synonym: "glucose 1-phosphate adenylyltransferase activity" EXACT [EC:2.7.7.27]
xref: EC:2.7.7.27
xref: KEGG:R00948
xref: MetaCyc:GLUC1PADENYLTRANS-RXN
xref: RHEA:12123
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0008879
name: glucose-1-phosphate thymidylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate + dTTP = diphosphate + dTDP-glucose." [EC:2.7.7.24, RHEA:15228]
subset: gosubset_prok
synonym: "dTDP-glucose diphosphorylase activity" EXACT [EC:2.7.7.24]
synonym: "dTDP-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.24]
synonym: "dTDP-glucose synthase activity" EXACT [EC:2.7.7.24]
synonym: "dTTP:alpha-D-glucose-1-phosphate thymidylyltransferase activity" EXACT [EC:2.7.7.24]
synonym: "glucose 1-phosphate thymidylyltransferase activity" EXACT [EC:2.7.7.24]
synonym: "TDP-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.24]
synonym: "thymidine diphosphate glucose pyrophosphorylase activity" EXACT [EC:2.7.7.24]
synonym: "thymidine diphosphoglucose pyrophosphorylase activity" EXACT [EC:2.7.7.24]
xref: EC:2.7.7.24
xref: KEGG:R02328
xref: MetaCyc:DTDPGLUCOSEPP-RXN
xref: RHEA:15228
is_a: GO:0016779 ! nucleotidyltransferase activity

[Term]
id: GO:0008880
name: glucuronate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucuronate = D-fructuronate." [EC:5.3.1.12]
subset: gosubset_prok
synonym: "D-glucuronate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.12]
synonym: "D-glucuronate isomerase activity" EXACT [EC:5.3.1.12]
synonym: "D-glucuronate ketol-isomerase activity" EXACT [EC:5.3.1.12]
synonym: "uronate isomerase activity" EXACT [EC:5.3.1.12]
synonym: "uronic acid isomerase activity" EXACT [EC:5.3.1.12]
synonym: "uronic isomerase activity" EXACT [EC:5.3.1.12]
xref: EC:5.3.1.12
xref: MetaCyc:GLUCUROISOM-RXN
xref: RHEA:13052
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0008881
name: glutamate racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamate = D-glutamate." [EC:5.1.1.3, RHEA:12816]
subset: gosubset_prok
xref: EC:5.1.1.3
xref: KEGG:R00260
xref: MetaCyc:GLUTRACE-RXN
xref: RHEA:12816
is_a: GO:0047661 ! amino-acid racemase activity

[Term]
id: GO:0008882
name: [glutamate-ammonia-ligase] adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + [L-glutamate:ammonia ligase (ADP-forming)] = diphosphate + adenylyl-[L-glutamate:ammonia ligase (ADP-forming)]." [EC:2.7.7.42]
subset: gosubset_prok
synonym: "adenosine triphosphate:glutamine synthetase adenylyltransferase activity" EXACT [EC:2.7.7.42]
synonym: "ATP:[glutamate-ammonia-ligase] adenylyltransferase activity" EXACT []
synonym: "ATP:glutamine synthetase adenylyltransferase activity" EXACT [EC:2.7.7.42]
synonym: "ATP:L-glutamate:ammonia ligase (ADP-forming) adenylyltransferase activity" EXACT [EC:2.7.7.42]
synonym: "glutamate-ammonia-ligase adenylyltransferase activity" EXACT []
synonym: "glutamine-synthetase adenylyltransferase activity" EXACT [EC:2.7.7.42]
xref: EC:2.7.7.42
xref: MetaCyc:GSADENYLATION-RXN
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0008883
name: glutamyl-tRNA reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = L-glutamyl-tRNA(Glu) + H(+) + NADPH." [EC:1.2.1.70, RHEA:12347]
subset: gosubset_prok
synonym: "L-glutamate-semialdehyde: NADP+ oxidoreductase (L-glutamyl-tRNAGlu-forming)" EXACT [EC:1.2.1.70]
xref: EC:1.2.1.70
xref: KEGG:R04109
xref: MetaCyc:GLUTRNAREDUCT-RXN
xref: RHEA:12347
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008884
name: glutathionylspermidine amidase activity
namespace: molecular_function
def: "Catalysis of the reaction: N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + H2O = gamma-L-glutamyl-L-cysteinyl-glycine + spermidine." [EC:3.5.1.78]
subset: gosubset_prok
synonym: "gamma-L-glutamyl-L-cysteinyl-glycine:spermidine amidase activity" EXACT [EC:3.5.1.78]
synonym: "glutathionylspermidine amidohydrolase (spermidine-forming) activity" EXACT [EC:3.5.1.78]
synonym: "GSP amidase activity" EXACT [EC:3.5.1.78]
xref: EC:3.5.1.78
xref: MetaCyc:GSPAMID-RXN
xref: RHEA:17176
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0008885
name: glutathionylspermidine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: gamma-L-glutamyl-L-cysteinyl-glycine + spermidine + ATP = N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + ADP + phosphate." [EC:6.3.1.8]
subset: gosubset_prok
synonym: "gamma-L-glutamyl-L-cysteinyl-glycine:spermidine ligase (ADP-forming) [spermidine is numbered so that atom N-1 is in the amino group of the aminopropyl part of the molecule]" RELATED [EC:6.3.1.8]
synonym: "gamma-L-glutamyl-L-cysteinyl-glycine:spermidine ligase (ADP-forming) activity" EXACT [EC:6.3.1.8]
synonym: "glutathione:spermidine ligase (ADP-forming) activity" EXACT [EC:6.3.1.8]
synonym: "glutathionylspermidine synthetase activity" EXACT [EC:6.3.1.8]
synonym: "GSP synthetase activity" EXACT [EC:6.3.1.8]
xref: EC:6.3.1.8
xref: MetaCyc:GSPSYN-RXN
xref: RHEA:21275
is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity

[Term]
id: GO:0008886
name: glyceraldehyde-3-phosphate dehydrogenase (NADP+) (non-phosphorylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + H(2)O + NADP(+) = 3-phospho-D-glycerate + 2 H(+) + NADPH." [EC:1.2.1.9, RHEA:14672]
subset: gosubset_prok
synonym: "D-glyceraldehyde-3-phosphate:NADP+ oxidoreductase activity" EXACT []
synonym: "dehydrogenase, glyceraldehyde phosphate (nicotinamide adenine dinucleotide phosphate)" BROAD []
synonym: "glyceraldehyde 3-phosphate dehydrogenase (NADP)" EXACT []
synonym: "glyceraldehyde phosphate dehydrogenase (NADP)" BROAD []
synonym: "glyceraldehyde-3-phosphate dehydrogenase (NADP)" EXACT []
synonym: "glyceraldehyde-3-phosphate:NADP reductase activity" EXACT []
synonym: "NADP-glyceraldehyde phosphate dehydrogenase" BROAD []
synonym: "NADP-glyceraldehyde-3-phosphate dehydrogenase activity" EXACT []
synonym: "nonphosphorylating glyceraldehyde-3-phosphate dehydrogenase activity" EXACT []
synonym: "triosephosphate dehydrogenase activity" BROAD [EC:1.2.1.9]
xref: EC:1.2.1.9
xref: KEGG:R01058
xref: MetaCyc:1.2.1.9-RXN
xref: RHEA:14672
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008887
name: glycerate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glycerate + ATP = 3-phospho-D-glycerate + ADP + 2 H(+)." [EC:2.7.1.31, RHEA:23519]
subset: gosubset_prok
synonym: "ATP:(R)-glycerate 3-phosphotransferase activity" EXACT [EC:2.7.1.31]
synonym: "ATP:D-glycerate 2-phosphotransferase activity" EXACT [EC:2.7.1.31]
synonym: "D-glycerate 3-kinase activity" EXACT [EC:2.7.1.31]
synonym: "D-glycerate kinase activity" EXACT [EC:2.7.1.31]
synonym: "D-glyceric acid kinase activity" EXACT [EC:2.7.1.31]
synonym: "GK" RELATED [EC:2.7.1.31]
synonym: "glycerate kinase (phosphorylating)" EXACT [EC:2.7.1.31]
synonym: "glycerate-3-kinase activity" EXACT [EC:2.7.1.31]
xref: EC:2.7.1.31
xref: KEGG:R01514
xref: MetaCyc:GLY3KIN-RXN
xref: RHEA:23519
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0008888
name: glycerol dehydrogenase [NAD+] activity
namespace: molecular_function
def: "Catalysis of the reaction: glycerol + NAD(+) = glycerone + H(+) + NADH." [EC:1.1.1.6, RHEA:13772]
subset: gosubset_prok
synonym: "glycerol dehydrogenase activity" BROAD []
synonym: "NAD-linked glycerol dehydrogenase activity" EXACT [EC:1.1.1.6]
xref: EC:1.1.1.6
xref: KEGG:R01034
xref: MetaCyc:GLYCDEH-RXN
xref: RHEA:13772
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008889
name: glycerophosphodiester phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate." [EC:3.1.4.46]
subset: gosubset_prok
synonym: "gene hpd protein" RELATED [EC:3.1.4.46]
synonym: "glycerophosphodiester glycerophosphohydrolase activity" EXACT [EC:3.1.4.46]
synonym: "glycerophosphoryl diester phosphodiesterase activity" EXACT [EC:3.1.4.46]
synonym: "IgD-binding protein D" RELATED [EC:3.1.4.46]
xref: EC:3.1.4.46
xref: MetaCyc:GLYCPDIESTER-RXN
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0008890
name: glycine C-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + glycine = L-2-amino-3-oxobutanoate + CoA + H(+)." [EC:2.3.1.29, RHEA:20739]
subset: gosubset_prok
synonym: "2-amino-3-ketobutyrate CoA ligase activity" EXACT [EC:2.3.1.29]
synonym: "2-amino-3-ketobutyrate coenzyme A ligase activity" EXACT [EC:2.3.1.29]
synonym: "2-amino-3-ketobutyrate-CoA ligase activity" EXACT [EC:2.3.1.29]
synonym: "acetyl-CoA:glycine C-acetyltransferase activity" EXACT [EC:2.3.1.29]
synonym: "aminoacetone synthase activity" EXACT [EC:2.3.1.29]
synonym: "glycine acetyltransferase activity" EXACT [EC:2.3.1.29]
xref: EC:2.3.1.29
xref: KEGG:R00371
xref: MetaCyc:AKBLIG-RXN
xref: RHEA:20739
is_a: GO:0016453 ! C-acetyltransferase activity

[Term]
id: GO:0008891
name: glycolate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycolate + O2 = glyoxylate + hydrogen peroxide." [EC:1.1.3.15]
subset: gosubset_prok
xref: MetaCyc:RXN-969
xref: Reactome:REACT_100543 "glycolate + O2 => glyoxylate + H2O2, Bos taurus"
xref: Reactome:REACT_104515 "glycolate + O2 => glyoxylate + H2O2, Mus musculus"
xref: Reactome:REACT_106230 "glycolate + O2 => glyoxylate + H2O2, Rattus norvegicus"
xref: Reactome:REACT_108103 "glycolate + O2 => glyoxylate + H2O2, Xenopus tropicalis"
xref: Reactome:REACT_109848 "glycolate + O2 => glyoxylate + H2O2, Canis familiaris"
xref: Reactome:REACT_112171 "glycolate + O2 => glyoxylate + H2O2, Mycobacterium tuberculosis"
xref: Reactome:REACT_112286 "glycolate + O2 => glyoxylate + H2O2, Oryza sativa"
xref: Reactome:REACT_112704 "glycolate + O2 => glyoxylate + H2O2, Dictyostelium discoideum"
xref: Reactome:REACT_113493 "glycolate + O2 => glyoxylate + H2O2, Escherichia coli"
xref: Reactome:REACT_113804 "glycolate + O2 => glyoxylate + H2O2, Arabidopsis thaliana"
xref: Reactome:REACT_114154 "glycolate + O2 => glyoxylate + H2O2, Drosophila melanogaster"
xref: Reactome:REACT_17020 "glycolate + O2 => glyoxylate + H2O2, Homo sapiens"
xref: Reactome:REACT_31504 "glycolate + O2 => glyoxylate + H2O2, Danio rerio"
xref: Reactome:REACT_78041 "glycolate + O2 => glyoxylate + H2O2, Gallus gallus"
xref: Reactome:REACT_89151 "glycolate + O2 => glyoxylate + H2O2, Caenorhabditis elegans"
xref: Reactome:REACT_92601 "glycolate + O2 => glyoxylate + H2O2, Taeniopygia guttata"
is_a: GO:0003973 ! (S)-2-hydroxy-acid oxidase activity

[Term]
id: GO:0008892
name: guanine deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: guanine + H2O = xanthine + NH3." [EC:3.5.4.3]
subset: gosubset_prok
synonym: "GAH activity" EXACT [EC:3.5.4.3]
synonym: "guanase activity" EXACT [EC:3.5.4.3]
synonym: "guanine aminase activity" EXACT [EC:3.5.4.3]
synonym: "guanine aminohydrolase activity" EXACT [EC:3.5.4.3]
xref: EC:3.5.4.3
xref: MetaCyc:GUANINE-DEAMINASE-RXN
xref: Reactome:REACT_100021 "Guanine + H2O => Xanthine + NH3, Xenopus tropicalis"
xref: Reactome:REACT_102945 "Guanine + H2O => Xanthine + NH3, Rattus norvegicus"
xref: Reactome:REACT_104237 "Guanine + H2O => Xanthine + NH3, Schizosaccharomyces pombe"
xref: Reactome:REACT_107253 "Guanine + H2O => Xanthine + NH3, Saccharomyces cerevisiae"
xref: Reactome:REACT_1442 "Guanine + H2O => Xanthine + NH3, Homo sapiens"
xref: Reactome:REACT_29585 "Guanine + H2O => Xanthine + NH3, Dictyostelium discoideum"
xref: Reactome:REACT_30054 "Guanine + H2O => Xanthine + NH3, Sus scrofa"
xref: Reactome:REACT_31176 "Guanine + H2O => Xanthine + NH3, Danio rerio"
xref: Reactome:REACT_31455 "Guanine + H2O => Xanthine + NH3, Oryza sativa"
xref: Reactome:REACT_34439 "Guanine + H2O => Xanthine + NH3, Gallus gallus"
xref: Reactome:REACT_78829 "Guanine + H2O => Xanthine + NH3, Mus musculus"
xref: Reactome:REACT_81559 "Guanine + H2O => Xanthine + NH3, Taeniopygia guttata"
xref: Reactome:REACT_91279 "Guanine + H2O => Xanthine + NH3, Drosophila melanogaster"
xref: Reactome:REACT_92579 "Guanine + H2O => Xanthine + NH3, Canis familiaris"
xref: Reactome:REACT_93510 "Guanine + H2O => Xanthine + NH3, Escherichia coli"
xref: Reactome:REACT_94677 "Guanine + H2O => Xanthine + NH3, Bos taurus"
xref: RHEA:14668
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0008893
name: guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate." [EC:3.1.7.2]
subset: gosubset_prok
synonym: "(ppGpp)ase activity" EXACT [EC:3.1.7.2]
synonym: "guanosine-3',5'-bis(diphosphate) 3'-diphosphohydrolase activity" EXACT []
synonym: "guanosine-3',5'-bis(diphosphate) 3'-pyrophosphatase activity" EXACT [EC:3.1.7.2]
synonym: "guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase activity" EXACT []
synonym: "penta-phosphate guanosine-3'-diphosphohydrolase activity" EXACT [EC:3.1.7.2]
synonym: "penta-phosphate guanosine-3'-pyrophosphohydrolase activity" EXACT [EC:3.1.7.2]
synonym: "PpGpp phosphohydrolase activity" EXACT [EC:3.1.7.2]
synonym: "PpGpp-3'-pyrophosphohydrolase activity" EXACT [EC:3.1.7.2]
xref: EC:3.1.7.2
xref: MetaCyc:PPGPPSYN-RXN
xref: RHEA:14256
is_a: GO:0016794 ! diphosphoric monoester hydrolase activity

[Term]
id: GO:0008894
name: guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 5'-diphosphate,3'-diphosphate + phosphate." [EC:3.6.1.40]
subset: gosubset_prok
synonym: "guanosine 5'-triphosphate 3'-diphosphate 5'-phosphatase activity" EXACT [EC:3.6.1.40]
synonym: "guanosine 5'-triphosphate-3'-diphosphate 5'-phosphohydrolase activity" EXACT [EC:3.6.1.40]
synonym: "guanosine pentaphosphatase activity" EXACT [EC:3.6.1.40]
synonym: "guanosine pentaphosphate phosphatase activity" EXACT [EC:3.6.1.40]
synonym: "guanosine pentaphosphate phosphohydrolase activity" EXACT [EC:3.6.1.40]
synonym: "guanosine-5'-triphosphate,3'-diphosphate 5'-phosphohydrolase activity" EXACT [EC:3.6.1.40]
synonym: "guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase activity" EXACT []
synonym: "pppGpp 5'-phosphohydrolase activity" EXACT [EC:3.6.1.40]
xref: EC:3.6.1.40
xref: MetaCyc:PPPGPPHYDRO-RXN
xref: RHEA:13076
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0008897
name: holo-[acyl-carrier-protein] synthase activity
namespace: molecular_function
alt_id: GO:0008958
def: "Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form." [EC:2.7.8.7, PMID:10320345, PMID:11867633, PMID:8939709]
subset: gosubset_prok
synonym: "4'-phosphopantetheinyl transferase activity" EXACT [EC:2.7.8.7]
synonym: "4'-phosphopantetheinyltransferase activity" EXACT []
synonym: "AcpS" RELATED [EC:2.7.8.7]
synonym: "ACPS activity" RELATED [EC:2.7.8.7]
synonym: "acyl carrier protein holoprotein (holo-ACP) synthetase activity" EXACT [EC:2.7.8.7]
synonym: "acyl carrier protein synthase activity" RELATED [EC:2.7.8.7]
synonym: "acyl carrier protein synthetase activity" RELATED [EC:2.7.8.7]
synonym: "alpha-aminoadipate reductase phosphopantetheinyl transferase activity" EXACT []
synonym: "alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase activity" EXACT [EC:2.7.8.7]
synonym: "alphaaminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase activity" EXACT [EC:2.7.8.7]
synonym: "CoA-[4'-phosphopantetheine]:apo-acyl-carrier-protein 4'-pantetheinephosphotransferase activity" EXACT [EC:2.7.8.7]
synonym: "CoA:apo-acyl-carrier-protein pantetheinephosphotransferase activity" EXACT [EC:2.7.8.7]
synonym: "coenzyme A:fatty acid synthetase apoenzyme 4'-phosphopantetheine transferase activity" EXACT [EC:2.7.8.7]
synonym: "holo-[acyl-carrier-protein] synthase activity" NARROW []
synonym: "holo-[peptidyl-carrier protein] synthase activity" NARROW []
synonym: "holo-ACP synthase activity" RELATED [EC:2.7.8.7]
synonym: "holo-ACP synthetase activity" RELATED [EC:2.7.8.7]
synonym: "holo-acyl-carrier-protein synthase activity" EXACT [EC:2.7.8.7]
synonym: "holosynthase activity" RELATED [EC:2.7.8.7]
synonym: "L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase activity" NARROW [EC:2.7.8.7]
synonym: "P-pant transferase activity" EXACT [EC:2.7.8.7]
synonym: "phosphopantetheinyltransferase activity" EXACT []
synonym: "PPTase activity" EXACT [EC:2.7.8.7]
xref: EC:2.7.8.7
xref: MetaCyc:HOLO-ACP-SYNTH-RXN
xref: Reactome:REACT_101260 "Phosphopantetheine conjugation of the ACP domain of FAS, Caenorhabditis elegans"
xref: Reactome:REACT_106943 "Phosphopantetheine conjugation of the ACP domain of FAS, Bos taurus"
xref: Reactome:REACT_108901 "Phosphopantetheine conjugation of the ACP domain of FAS, Gallus gallus"
xref: Reactome:REACT_11175 "Phosphopantetheine conjugation of the ACP domain of FAS, Homo sapiens"
xref: Reactome:REACT_114029 "Phosphopantetheine conjugation of the ACP domain of FAS, Dictyostelium discoideum"
xref: Reactome:REACT_114181 "Phosphopantetheine conjugation of the ACP domain of FAS, Xenopus tropicalis"
xref: Reactome:REACT_34019 "Phosphopantetheine conjugation of the ACP domain of FAS, Taeniopygia guttata"
xref: Reactome:REACT_83956 "Phosphopantetheine conjugation of the ACP domain of FAS, Mus musculus"
xref: Reactome:REACT_91705 "Phosphopantetheine conjugation of the ACP domain of FAS, Drosophila melanogaster"
xref: Reactome:REACT_96325 "Phosphopantetheine conjugation of the ACP domain of FAS, Danio rerio"
xref: Reactome:REACT_99586 "Phosphopantetheine conjugation of the ACP domain of FAS, Canis familiaris"
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0008898
name: S-adenosylmethionine-homocysteine S-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + L-homocysteine = S-adenosyl-L-homocysteine + L-methionine." [EC:2.1.1.10, GOC:BHF, GOC:dph]
subset: gosubset_prok
synonym: "adenosylmethionine transmethylase activity" EXACT [EC:2.1.1.10]
synonym: "adenosylmethionine:homocysteine methyltransferase activity" EXACT [EC:2.1.1.10]
synonym: "homocysteine methyltransferase activity" RELATED [EC:2.1.1.10]
synonym: "homocysteine transmethylase activity" RELATED [EC:2.1.1.10]
synonym: "L-homocysteine S-methyltransferase activity" RELATED [EC:2.1.1.10]
synonym: "S-adenosyl-L-methionine:L-homocysteine methyltransferase activity" EXACT [EC:2.1.1.10]
synonym: "S-adenosyl-L-methionine:L-homocysteine S-methyltransferase activity" EXACT [EC:2.1.1.10]
synonym: "S-adenosylmethionine homocysteine transmethylase activity" EXACT [EC:2.1.1.10]
synonym: "S-adenosylmethionine-homocysteine transmethylase activity" EXACT [EC:2.1.1.10]
synonym: "S-adenosylmethionine:homocysteine methyltransferase activity" EXACT [EC:2.1.1.10]
xref: MetaCyc:HOMOCYSTEINE-S-METHYLTRANSFERASE-RXN
xref: RHEA:21823
is_a: GO:0008172 ! S-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0008899
name: homoserine O-succinyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-homoserine + succinyl-CoA = O-succinyl-L-homoserine + CoA." [EC:2.3.1.46, RHEA:22011]
subset: gosubset_prok
synonym: "homoserine O-transsuccinylase activity" BROAD [EC:2.3.1.46]
synonym: "homoserine succinyltransferase activity" EXACT [EC:2.3.1.46]
synonym: "succinyl-CoA:L-homoserine O-succinyltransferase activity" EXACT [EC:2.3.1.46]
xref: EC:2.3.1.46
xref: KEGG:R01777
xref: MetaCyc:HOMSUCTRAN-RXN
xref: RHEA:22011
is_a: GO:0016750 ! O-succinyltransferase activity

[Term]
id: GO:0008900
name: hydrogen:potassium-exchanging ATPase activity
namespace: molecular_function
alt_id: GO:0005390
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) + K+(out) = ADP + phosphate + H+(out) + K+(in)." [EC:3.6.3.10]
subset: gosubset_prok
synonym: "(K+ + H+)-ATPase activity" EXACT [EC:3.6.3.10]
synonym: "ATP phosphohydrolase (H+/K+-exchanging)" EXACT [EC:3.6.3.10]
synonym: "gastric H(+)/K(+) ATPase activity" NARROW [EC:3.6.3.10]
synonym: "gastric H+/K+ ATPase" NARROW [EC:3.6.3.10]
synonym: "H(+)/K(+)-ATPase activity" EXACT [EC:3.6.3.10]
synonym: "H(+)/K(+)-exchanging ATPase activity" EXACT [EC:3.6.3.10]
synonym: "H+-K+-ATPase activity" EXACT [EC:3.6.3.10]
synonym: "H+/K+-ATPase activity" EXACT [EC:3.6.3.10]
synonym: "H+/K+-exchanging ATPase activity" EXACT [EC:3.6.3.10]
synonym: "H,K-ATPase activity" EXACT [EC:3.6.3.10]
synonym: "hydrogen/potassium-exchanging ATPase activity" EXACT []
synonym: "hydrogen:potassium exchanging ATPase activity" EXACT []
synonym: "proton pump activity" BROAD [EC:3.6.3.10]
xref: EC:3.6.3.10
xref: Reactome:REACT_25173 "The K+-transporting ATPase mediates the exchange of potassium and hydrogen ions, Homo sapiens"
xref: RHEA:22047
is_a: GO:0008556 ! potassium-transporting ATPase activity
is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity

[Term]
id: GO:0008901
name: ferredoxin hydrogenase activity
namespace: molecular_function
alt_id: GO:0016948
alt_id: GO:0016949
alt_id: GO:0016950
alt_id: GO:0016951
def: "Catalysis of the reaction: 2 reduced ferredoxin + 2 H+ = 2 oxidized ferredoxin + H2." [EC:1.12.7.2]
comment: Note that this function was formerly EC 1.12.1.1, EC 1.12.7.1, EC 1.98.1.1, EC 1.18.3.1 and EC 1.18.99.1.
subset: gosubset_prok
synonym: "[Fe] hydrogenase activity" EXACT []
synonym: "[Fe] hydrogenase gamma" RELATED []
synonym: "bidirectional hydrogenase activity" BROAD [EC:1.12.7.2]
synonym: "H(2) oxidizing hydrogenase activity" BROAD [EC:1.12.7.2]
synonym: "H(2) producing hydrogenase activity" BROAD [EC:1.12.7.2]
synonym: "H2 oxidizing hydrogenase" BROAD []
synonym: "H2 producing hydrogenase" BROAD []
synonym: "hydrogen-lyase activity" BROAD [EC:1.12.7.2]
synonym: "hydrogen:ferredoxin oxidoreductase activity" EXACT []
synonym: "hydrogenase (ferredoxin) activity" EXACT [EC:1.12.7.2]
synonym: "hydrogenase activity" BROAD []
synonym: "hydrogenase I" RELATED []
synonym: "hydrogenase II" RELATED []
synonym: "hydrogenlyase activity" BROAD [EC:1.12.7.2]
synonym: "iron hydrogenase activity" NARROW []
synonym: "iron-only hydrogenase activity" NARROW []
synonym: "Ni-Fe hydrogenase activity" NARROW []
synonym: "Ni-Fe-Se hydrogenase activity" NARROW []
synonym: "nickel hydrogenase activity" NARROW []
synonym: "nickel-iron hydrogenase activity" NARROW []
synonym: "nickel-iron-selenium hydrogenase activity" NARROW []
synonym: "uptake hydrogenase activity" BROAD [EC:1.12.7.2]
xref: EC:1.12.7.2
xref: MetaCyc:HYDROG-RXN
xref: UM-BBD_enzymeID:e0418
is_a: GO:0016699 ! oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor

[Term]
id: GO:0008902
name: hydroxymethylpyrimidine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-methyl-5-phosphomethylpyrimidine + ADP + 2 H(+)." [EC:2.7.1.49, RHEA:23099]
subset: gosubset_prok
synonym: "ATP:4-amino-5-hydroxymethyl-2-methylpyrimidine 5-phosphotransferase activity" EXACT [EC:2.7.1.49]
synonym: "hydroxymethylpyrimidine kinase (phosphorylating)" EXACT [EC:2.7.1.49]
xref: EC:2.7.1.49
xref: KEGG:R03471
xref: MetaCyc:OHMETPYRKIN-RXN
xref: RHEA:23099
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0008903
name: hydroxypyruvate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxypyruvate = 2-hydroxy-3-oxopropanoate." [EC:5.3.1.22, RHEA:11955]
subset: gosubset_prok
synonym: "hydroxypyruvate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.22]
synonym: "hydroxypyruvate ketol-isomerase activity" EXACT [EC:5.3.1.22]
xref: EC:5.3.1.22
xref: KEGG:R01394
xref: MetaCyc:RXN0-305
xref: RHEA:11955
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0008904
name: hygromycin-B 7''-O-phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + hygromycin B = 7''-O-phosphohygromycin B + ADP + 2 H(+)." [EC:2.7.1.119, RHEA:23391]
subset: gosubset_prok
synonym: "APH(7'') activity" RELATED [EC:2.7.1.119]
synonym: "ATP:hygromycin-B 7''-O-phosphotransferase activity" EXACT [EC:2.7.1.119]
synonym: "destomic acid ring 7''-O-phosphotransferase activity" EXACT []
synonym: "hygromycin B kinase activity" BROAD []
synonym: "hygromycin B phosphotransferase activity" BROAD [EC:2.7.1.119]
synonym: "hygromycin-B kinase activity" BROAD []
xref: EC:2.7.1.119
xref: KEGG:R03770
xref: MetaCyc:HYGROMYCIN-B-KINASE-RXN
xref: RHEA:23391
is_a: GO:0034071 ! aminoglycoside phosphotransferase activity

[Term]
id: GO:0008905
name: mannose-phosphate guanylyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a phosphate group from GTP or GDP to a mannose molecule." [GOC:mah]
subset: gosubset_prok
xref: EC:2.7.7.-
is_a: GO:0070568 ! guanylyltransferase activity

[Term]
id: GO:0008906
name: inosine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + inosine = ADP + IMP." [EC:2.7.1.73]
subset: gosubset_prok
synonym: "ATP:inosine 5'-phosphotransferase activity" EXACT [EC:2.7.1.73]
synonym: "inosine kinase (phosphorylating)" EXACT [EC:2.7.1.73]
synonym: "inosine-guanosine kinase activity" RELATED [EC:2.7.1.73]
xref: EC:2.7.1.73
xref: MetaCyc:INOSINEKIN-RXN
xref: RHEA:21143
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0008907
name: integrase activity
namespace: molecular_function
def: "Catalysis of the integration of one segment of DNA into another." [GOC:mah]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0003824 ! catalytic activity
relationship: part_of GO:0015074 ! DNA integration

[Term]
id: GO:0008908
name: isochorismatase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + isochorismate = 2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate." [EC:3.3.2.1, RHEA:11115]
subset: gosubset_prok
synonym: "2,3 dihydro-2,3 dihydroxybenzoate synthase activity" EXACT [EC:3.3.2.1]
synonym: "2,3-dihydro-2,3-dihydroxybenzoate synthase activity" EXACT [EC:3.3.2.1]
synonym: "2,3-dihydroxy-2,3-dihydrobenzoate synthase activity" EXACT [EC:3.3.2.1]
synonym: "2,3-dihydroxy-2,3-dihydrobenzoic synthase activity" EXACT [EC:3.3.2.1]
synonym: "isochorismate pyruvate-hydrolase activity" EXACT [EC:3.3.2.1]
xref: EC:3.3.2.1
xref: KEGG:R03037
xref: MetaCyc:ISOCHORMAT-RXN
xref: RHEA:11115
is_a: GO:0004463 ! leukotriene-A4 hydrolase activity

[Term]
id: GO:0008909
name: isochorismate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: chorismate = isochorismate." [EC:5.4.4.2, RHEA:18988]
comment: Note that this function was formerly EC:5.4.99.6.
subset: gosubset_prok
synonym: "isochorismate hydroxymutase activity" EXACT [EC:5.4.4.2]
synonym: "isochorismate mutase activity" EXACT []
synonym: "isochorismate synthetase activity" EXACT [EC:5.4.4.2]
xref: EC:5.4.4.2
xref: KEGG:R01717
xref: MetaCyc:ISOCHORSYN-RXN
xref: RHEA:18988
is_a: GO:0050486 ! intramolecular transferase activity, transferring hydroxy groups

[Term]
id: GO:0008910
name: kanamycin kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + kanamycin = ADP + 2 H(+) + kanamycin 3'-phosphate." [EC:2.7.1.95, RHEA:24259]
subset: gosubset_prok
synonym: "aminoglycoside 3'-phosphotransferase activity" EXACT [EC:2.7.1.95]
synonym: "APH(3') activity" EXACT [EC:2.7.1.95]
synonym: "ATP:kanamycin 3'-O-phosphotransferase activity" EXACT [EC:2.7.1.95]
synonym: "kanamycin kinase (phosphorylating)" EXACT [EC:2.7.1.95]
synonym: "neomycin phosphotransferase activity" EXACT [EC:2.7.1.95]
synonym: "neomycin-kanamycin phosphotransferase activity" EXACT [EC:2.7.1.95]
xref: EC:2.7.1.95
xref: KEGG:R01888
xref: MetaCyc:KANAMYCIN-KINASE-RXN
xref: RHEA:24259
is_a: GO:0034071 ! aminoglycoside phosphotransferase activity

[Term]
id: GO:0008911
name: lactaldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-lactaldehyde + NAD+ + H2O = (S)-lactate + NADH + H+." [EC:1.2.1.22]
subset: gosubset_prok
synonym: "(S)-lactaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.22]
synonym: "L-lactaldehyde:NAD oxidoreductase activity" EXACT [EC:1.2.1.22]
synonym: "nicotinamide adenine dinucleotide (NAD)-linked dehydrogenase activity" EXACT [EC:1.2.1.22]
xref: EC:1.2.1.22
xref: MetaCyc:LACTALDDEHYDROG-RXN
xref: RHEA:14280
is_a: GO:0004029 ! aldehyde dehydrogenase (NAD) activity

[Term]
id: GO:0008912
name: lactaldehyde reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: propane-1,2-diol + NAD+ = lactaldehyde + NADH + H+." [EC:1.1.1.77]
subset: gosubset_prok
synonym: "(R)- or (S)-propane-1,2-diol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.77]
synonym: "lactaldehyde:propanediol oxidoreductase activity" EXACT [EC:1.1.1.77]
synonym: "propanediol oxidoreductase activity" BROAD [EC:1.1.1.77]
synonym: "propanediol:nicotinamide adenine dinucleotide (NAD) oxidoreductase activity" EXACT [EC:1.1.1.77]
xref: EC:1.1.1.77
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008913
name: lauroyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a lauroyl (dodecanoyl) group from one compound to another." [GOC:jl, ISBN:0198506732]
synonym: "lauroyl transferase activity" EXACT []
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0008914
name: leucyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-leucyl-tRNA + protein = tRNA + L-leucyl-protein." [EC:2.3.2.6]
subset: gosubset_prok
synonym: "L-leucyl-tRNA:protein leucyltransferase activity" EXACT [EC:2.3.2.6]
synonym: "L/F transferase activity" EXACT [EC:2.3.2.6]
synonym: "leucyl, phenylalanine-tRNA-protein transferase activity" EXACT [EC:2.3.2.6]
synonym: "leucyl-phenylalanine-transfer ribonucleate-protein aminoacyltransferase activity" EXACT [EC:2.3.2.6]
synonym: "leucyl-phenylalanine-transfer ribonucleate-protein transferase activity" EXACT [EC:2.3.2.6]
synonym: "leucyl-tRNA--protein transferase activity" EXACT [EC:2.3.2.6]
synonym: "leucyl/phenylalanyl-tRNA--protein transferase activity" EXACT [EC:2.3.2.6]
xref: EC:2.3.2.6
xref: MetaCyc:LEUCYLTRANSFERASE-RXN
is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups

[Term]
id: GO:0008915
name: lipid-A-disaccharide synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate + UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine = 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-(1->6)-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate + H(+) + UDP." [EC:2.4.1.182, RHEA:22671]
subset: gosubset_prok
synonym: "UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine:2,3-bis-(3-hydroxytetradecanoyl)-beta-D-glucosaminyl-1-phosphate 2,3-bis(3-hydroxytetradecanoyl)-glucosaminyltransferase activity" EXACT [EC:2.4.1.182]
xref: EC:2.4.1.182
xref: KEGG:R04606
xref: MetaCyc:LIPIDADISACCHARIDESYNTH-RXN
xref: RHEA:22671
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0008917
name: lipopolysaccharide N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lipopolysaccharide = UDP + N-acetyl-D-glucosaminyl-lipopolysaccharide." [EC:2.4.1.56, GOC:mr, KEGG:00540]
subset: gosubset_prok
synonym: "LPS N-acetylglucosaminyltransferase activity" EXACT []
synonym: "UDP-N-acetyl-D-glucosamine:lipopolysaccharide N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.56]
synonym: "UDP-N-acetylglucosamine-lipopolysaccharide N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.56]
synonym: "uridine diphosphoacetylglucosamine-lipopolysaccharide acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.56]
xref: EC:2.4.1.56
xref: MetaCyc:2.4.1.56-RXN
is_a: GO:0008375 ! acetylglucosaminyltransferase activity
relationship: part_of GO:0009103 ! lipopolysaccharide biosynthetic process

[Term]
id: GO:0008918
name: lipopolysaccharide 3-alpha-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,3 alpha-D-galactosyl-lipopolysaccharide." [EC:2.4.1.44, GOC:mr, KEGG:00540]
subset: gosubset_prok
synonym: "lipopolysaccharide 1,3-galactosyltransferase activity" EXACT [EC:2.4.1.44]
synonym: "lipopolysaccharide galactosyltransferase activity" EXACT []
synonym: "lipopolysaccharide-alpha-1,3-D-galactosyltransferase" NARROW []
synonym: "LPS 3-alpha-galactosyltransferase activity" EXACT []
synonym: "UDP-galactose:lipopolysaccharide 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.44]
synonym: "UDP-galactose:lipopolysaccharide alpha,3-galactosyltransferase activity" EXACT [EC:2.4.1.44]
synonym: "UDP-galactose:polysaccharide galactosyltransferase activity" EXACT [EC:2.4.1.44]
synonym: "UDPgalactose:lipopolysaccharide 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.44]
synonym: "uridine diphosphate galactose:lipopolysaccharide alpha-3-galactosyltransferase activity" EXACT [EC:2.4.1.44]
synonym: "uridine diphosphogalactose-lipopolysaccharide alpha,3-galactosyltransferase activity" EXACT [EC:2.4.1.44]
xref: EC:2.4.1.44
xref: MetaCyc:2.4.1.44-RXN
is_a: GO:0035250 ! UDP-galactosyltransferase activity
relationship: part_of GO:0009103 ! lipopolysaccharide biosynthetic process

[Term]
id: GO:0008919
name: lipopolysaccharide glucosyltransferase I activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + lipopolysaccharide = UDP + D-glucosyl-lipopolysaccharide." [EC:2.4.1.58, GOC:mr, KEGG:00540]
subset: gosubset_prok
synonym: "lipopolysaccharide glucosyltransferase activity" EXACT [EC:2.4.1.58]
synonym: "LPS glucosyltransferase I activity" EXACT []
synonym: "UDP-glucose:lipopolysaccharide glucosyltransferase activity" EXACT [EC:2.4.1.58]
synonym: "UDPglucose:lipopolysaccharide glucosyltransferase activity" EXACT [EC:2.4.1.58]
synonym: "UDPglucose:lipopolysaccharide glucosyltransferase I" RELATED [EC:2.4.1.58]
synonym: "uridine diphosphate glucose:lipopolysaccharide glucosyltransferase I" RELATED [EC:2.4.1.58]
synonym: "uridine diphosphoglucose-lipopolysaccharide glucosyltransferase activity" EXACT [EC:2.4.1.58]
xref: EC:2.4.1.58
xref: MetaCyc:2.4.1.58-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity
relationship: part_of GO:0009103 ! lipopolysaccharide biosynthetic process

[Term]
id: GO:0008920
name: lipopolysaccharide heptosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a lipopolysaccharide + ADP-L-glycero-beta-D-manno-heptose = a heptosylated lipopolysaccharide + ADP + H+." [MetaCyc:RXN0-5061, MetaCyc:RXN0-5122, MetaCyc:RXN0-5127]
subset: gosubset_prok
synonym: "LPS heptosyltransferase activity" EXACT []
is_a: GO:0016757 ! transferase activity, transferring glycosyl groups

[Term]
id: GO:0008921
name: lipopolysaccharide-1,6-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,6 alpha-D-galactosyl-lipopolysaccharide." [GOC:ai]
synonym: "LPS-1,6-galactosyltransferase activity" EXACT []
xref: EC:2.4.1.-
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0008922
name: long-chain fatty acid [acyl-carrier-protein] ligase activity
namespace: molecular_function
alt_id: GO:0010300
def: "Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]. A long-chain fatty acid is fatty acid with a chain length between C13 and C22." [CHEBI:15904, EC:6.2.1.20]
subset: gosubset_prok
synonym: "acyl-[acyl-carrier-protein] synthetase activity" EXACT [EC:6.2.1.20]
synonym: "acyl-ACP synthetase activity" EXACT []
synonym: "acyl-acyl carrier protein synthetase" BROAD [EC:6.2.1.20]
synonym: "acyl-acyl-carrier-protein synthetase activity" EXACT [EC:6.2.1.20]
synonym: "acyl-acyl-carrier-proteinsynthetase activity" EXACT [EC:6.2.1.20]
synonym: "long-chain fatty acid-[acyl-carrier-protein] ligase activity" EXACT []
synonym: "long-chain-fatty-acid-[acyl-carrier protein] ligase activity" EXACT []
synonym: "long-chain-fatty-acid-[acyl-carrier-protein] ligase activity" EXACT []
synonym: "long-chain-fatty-acid-ACP ligase activity" EXACT []
synonym: "long-chain-fatty-acid-acyl-carrier-protein ligase activity" EXACT [EC:6.2.1.20]
synonym: "long-chain-fatty-acid:acyl-carrier-protein ligase (AMP-forming) activity" EXACT [EC:6.2.1.20]
synonym: "stearoyl-ACP synthetase activity" EXACT [EC:6.2.1.20]
xref: EC:6.2.1.20
xref: KEGG:R07325
xref: MetaCyc:ACYLACPSYNTH-RXN
is_a: GO:0015645 ! fatty acid ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0008923
name: lysine decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-lysine + H(+) = cadaverine + CO(2)." [EC:4.1.1.18, RHEA:22355]
subset: gosubset_prok
synonym: "L-lysine carboxy-lyase (cadaverine-forming)" EXACT [EC:4.1.1.18]
synonym: "L-lysine carboxy-lyase activity" EXACT [EC:4.1.1.18]
xref: EC:4.1.1.18
xref: KEGG:R00462
xref: MetaCyc:LYSDECARBOX-RXN
xref: MetaCyc:PWY0-461
xref: RHEA:22355
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0008924
name: malate dehydrogenase (quinone) activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-malate + a quinone = oxaloacetate + a quinol." [MetaCyc:MALATE-DEHYDROGENASE-ACCEPTOR-RXN]
subset: gosubset_prok
synonym: "(S)-malate:(quinone) oxidoreductase activity" EXACT [EC:1.1.5.4]
synonym: "(S)-malate:quinone oxidoreductase activity" EXACT [EC:1.1.5.4]
synonym: "FAD-dependent malate dehydrogenase activity" EXACT [EC:1.1.5.4]
synonym: "MQO activity" BROAD [EC:1.1.5.4]
xref: EC:1.1.5.4
xref: MetaCyc:MALATE-DEHYDROGENASE-ACCEPTOR-RXN
xref: RHEA:22559
is_a: GO:0016615 ! malate dehydrogenase activity
is_a: GO:0016901 ! oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor

[Term]
id: GO:0008925
name: maltose O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + maltose = CoA + acetyl-maltose." [EC:2.3.1.79]
subset: gosubset_prok
synonym: "acetyl-CoA:maltose O-acetyltransferase activity" EXACT [EC:2.3.1.79]
synonym: "maltose transacetylase activity" EXACT [EC:2.3.1.79]
xref: EC:2.3.1.79
xref: MetaCyc:MALTACETYLTRAN-RXN
xref: RHEA:10459
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0008926
name: mannitol-1-phosphate 5-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH + H+." [EC:1.1.1.17]
subset: gosubset_prok
xref: EC:1.1.1.17
xref: MetaCyc:MANNPDEHYDROG-RXN
xref: RHEA:19664
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008927
name: mannonate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H(2)O." [EC:4.2.1.8, RHEA:20100]
subset: gosubset_prok
synonym: "altronate hydrolase activity" EXACT [EC:4.2.1.8]
synonym: "altronic hydro-lyase activity" EXACT [EC:4.2.1.8]
synonym: "D-mannonate hydro-lyase (2-dehydro-3-deoxy-D-gluconate-forming)" EXACT [EC:4.2.1.8]
synonym: "D-mannonate hydro-lyase activity" EXACT [EC:4.2.1.8]
synonym: "D-mannonate hydrolyase activity" EXACT [EC:4.2.1.8]
synonym: "mannonate hydrolyase activity" EXACT [EC:4.2.1.8]
synonym: "mannonic hydrolase activity" EXACT [EC:4.2.1.8]
xref: EC:4.2.1.8
xref: KEGG:R05606
xref: MetaCyc:MANNONDEHYDRAT-RXN
xref: RHEA:20100
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0008928
name: mannose-1-phosphate guanylyltransferase (GDP) activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-mannose 1-phosphate + GDP + H(+) = GDP-alpha-D-mannose + phosphate." [EC:2.7.7.22, RHEA:12908]
subset: gosubset_prok
synonym: "GDP mannose phosphorylase activity" EXACT [EC:2.7.7.22]
synonym: "GDP-mannose 1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.22]
synonym: "GDP-mannose phosphorylase activity" EXACT [EC:2.7.7.22]
synonym: "GDP-mannose pyrophosphorylase activity" RELATED [EC:2.7.7.22]
synonym: "GDP:alpha-D-mannose-1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.22]
synonym: "GDP:D-mannose-1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.22]
synonym: "GDP:mannose-1-phosphate guanylyltransferase activity" EXACT []
synonym: "guanosine diphosphate-mannose 1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.22]
synonym: "guanosine diphosphomannose phosphorylase activity" EXACT [EC:2.7.7.22]
synonym: "mannose 1-phosphate (guanosine diphosphate) guanylyltransferase activity" EXACT [EC:2.7.7.22]
synonym: "mannose 1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.22]
xref: EC:2.7.7.22
xref: KEGG:R00883
xref: MetaCyc:MANNPGUANYLTRANGDP-RXN
xref: RHEA:12908
is_a: GO:0008905 ! mannose-phosphate guanylyltransferase activity

[Term]
id: GO:0008929
name: methylglyoxal synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycerone phosphate = methylglyoxal + phosphate." [EC:4.2.3.3, RHEA:17940]
subset: gosubset_prok
synonym: "glycerone-phosphate phospho-lyase (methylglyoxal-forming)" EXACT [EC:4.2.3.3]
synonym: "glycerone-phosphate phospho-lyase activity" EXACT [EC:4.2.3.3]
synonym: "methylglyoxal synthetase activity" EXACT [EC:4.2.3.3]
xref: EC:4.2.3.3
xref: KEGG:R01016
xref: MetaCyc:METHGLYSYN-RXN
xref: RHEA:17940
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0008930
name: methylthioadenosine nucleosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: methylthioadenosine + H2O = adenine + 5-methylthio-D-ribose." [EC:3.2.2.16]
subset: gosubset_prok
synonym: "5'-methylthioadenosine nucleosidase activity" EXACT [EC:3.2.2.16]
synonym: "MeSAdo nucleosidase activity" EXACT [EC:3.2.2.16]
synonym: "methylthioadenosine methylthioribohydrolase activity" EXACT [EC:3.2.2.16]
synonym: "MTA nucleosidase activity" EXACT [EC:3.2.2.16]
synonym: "S-methyl-5'-thioadenosine adeninehyrolase activity" EXACT [EC:3.2.2.16]
xref: EC:3.2.2.16
xref: MetaCyc:METHYLTHIOADENOSINE-NUCLEOSIDASE-RXN
xref: RHEA:13620
is_a: GO:0008477 ! purine nucleosidase activity

[Term]
id: GO:0008931
name: obsolete murein DD-endopeptidase activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "murein DD-endopeptidase activity" EXACT []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0008932
name: lytic endotransglycosylase activity
namespace: molecular_function
def: "Catalysis of the specific cleavage of the beta-(1->4) glycosidic linkage between N-acetylmuramyl and N-acetylglucosaminyl residues in peptidoglycan, with the concomitant formation of 1,6-anhydro-N-acetylmuramyl residues. Acts on linkages within peptidoglycan chains (i.e. not at the ends) to produce shorter strands with 1,6-anhydromuramic acid ends." [PMID:10964424, PMID:9642199]
synonym: "murein lytic endotransglycosylase E activity" NARROW []
xref: EC:2.4.99.-
is_a: GO:0008933 ! lytic transglycosylase activity

[Term]
id: GO:0008933
name: lytic transglycosylase activity
namespace: molecular_function
def: "Catalysis of the specific cleavage of the beta-(1->4) glycosidic linkage between N-acetylmuramyl and N-acetylglucosaminyl residues in peptidoglycan, with the concomitant formation of 1,6-anhydro-N-acetylmuramyl residues." [PMID:10964424]
subset: gosubset_prok
synonym: "murein transglycosylase B activity" NARROW []
synonym: "peptidoglycan lytic transglycosylase activity" EXACT []
xref: EC:3.2.1.-
is_a: GO:0016757 ! transferase activity, transferring glycosyl groups

[Term]
id: GO:0008934
name: inositol monophosphate 1-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: myo-inositol 1-phosphate + H2O = myo-inositol + phosphate." [EC:3.1.3.25]
subset: gosubset_prok
synonym: "inositol 1-phosphatase activity" EXACT [EC:3.1.3.25]
synonym: "inositol-1(or 4)-monophosphatase activity" BROAD [EC:3.1.3.25]
synonym: "L-myo-inositol-1-phosphate phosphatase activity" EXACT [EC:3.1.3.25]
synonym: "myo-inositol 1-phosphatase activity" EXACT [EC:3.1.3.25]
synonym: "myo-inositol-1(or 4)-monophosphatase activity" BROAD []
synonym: "myo-inositol-1(or 4)-phosphate phosphohydrolase activity" BROAD [EC:3.1.3.25]
synonym: "myo-inositol-1-phosphatase activity" EXACT [EC:3.1.3.25]
xref: EC:3.1.3.25
xref: MetaCyc:RXN0-5408
xref: Reactome:REACT_27149 "acetylglucosamine-inositol-phosphate is dephosphorylated, Mycobacterium tuberculosis"
xref: RHEA:27673
is_a: GO:0052834 ! inositol monophosphate phosphatase activity

[Term]
id: GO:0008935
name: 1,4-dihydroxy-2-naphthoyl-CoA synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-(2-carboxyphenyl)-4-oxobutanoyl-CoA = 1,4-dihydroxy-2-napthoyl-CoA + H2O." [EC:4.1.3.36]
subset: gosubset_prok
synonym: "1,4-dihydroxy-2-naphthoate synthase activity" EXACT [EC:4.1.3.36]
synonym: "DHNA synthetase activity" EXACT [EC:4.1.3.36]
synonym: "dihydroxynaphthoate synthase activity" EXACT [EC:4.1.3.36]
synonym: "dihydroxynaphthoic acid synthetase activity" EXACT [EC:4.1.3.36]
synonym: "O-succinylbenzoyl-CoA 1,4-dihydroxy-2-naphthoate-lyase (cyclizing) activity" EXACT [EC:4.1.3.36]
synonym: "O-succinylbenzoyl-CoA 1,4-dihydroxy-2-naphthoate-lyase (cyclizing; CoA-forming)" EXACT [EC:4.1.3.36]
synonym: "O-succinylbenzoyl-CoA 1,4-dihydroxy-2-naphthoate-lyase activity" RELATED [KEGG:R04150]
xref: EC:4.1.3.36
xref: KEGG:R04150
xref: MetaCyc:NAPHTHOATE-SYN-RXN
xref: RHEA:15528
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0008936
name: nicotinamidase activity
namespace: molecular_function
def: "Catalysis of the reaction: nicotinamide + H2O = nicotinate + NH3." [EC:3.5.1.19]
subset: gosubset_prok
synonym: "NAMase activity" EXACT [EC:3.5.1.19]
synonym: "nicotinamide amidase activity" EXACT [EC:3.5.1.19]
synonym: "nicotinamide amidohydrolase activity" EXACT [EC:3.5.1.19]
synonym: "nicotinamide deaminase activity" EXACT [EC:3.5.1.19]
synonym: "nicotine deamidase activity" EXACT [EC:3.5.1.19]
synonym: "YNDase activity" EXACT [EC:3.5.1.19]
xref: EC:3.5.1.19
xref: MetaCyc:NICOTINAMID-RXN
xref: Reactome:REACT_11101 "E.Coli deamination of nicotinamide, Escherichia coli"
xref: Reactome:REACT_11136 "Deamination of nicotinamide to nicotinate, Homo sapiens"
xref: RHEA:14548
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0008937
name: ferredoxin-NAD(P) reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: reduced ferredoxin + NAD(P)+ = oxidized ferredoxin + NAD(P)H + H+." [EC:1.18.1.-]
subset: gosubset_prok
synonym: "ferredoxin reductase activity" BROAD []
xref: EC:1.18.1.-
is_a: GO:0016731 ! oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor

[Term]
id: GO:0008938
name: nicotinate N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nicotinate = N-methylnicotinate + S-adenosyl-L-homocysteine." [EC:2.1.1.7, RHEA:20244]
synonym: "furanocoumarin 8-O-methyltransferase activity" EXACT [EC:2.1.1.7]
synonym: "S-adenosyl-L-methionine:nicotinate N-methyltransferase activity" EXACT [EC:2.1.1.7]
xref: EC:2.1.1.7
xref: KEGG:R01721
xref: MetaCyc:NICOTINATE-N-METHYLTRANSFERASE-RXN
xref: RHEA:20244
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0008939
name: nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,6-dimethylbenzimidazole + nicotinate D-ribonucleotide = alpha-ribazole 5'-phosphate + H(+) + nicotinate." [EC:2.4.2.21, RHEA:11199]
subset: gosubset_prok
synonym: "CobT" RELATED [EC:2.4.2.21]
synonym: "N(1)-alpha-phosphoribosyltransferase activity" EXACT [EC:2.4.2.21]
synonym: "N1-alpha-phosphoribosyltransferase activity" EXACT [EC:2.4.2.21]
synonym: "nicotinate mononucleotide (NaMN):5,6-dimethylbenzimidazole phosphoribosyltransferase activity" EXACT [EC:2.4.2.21]
synonym: "nicotinate mononucleotide-dimethylbenzimidazole phosphoribosyltransferase activity" EXACT [EC:2.4.2.21]
synonym: "nicotinate ribonucleotide:benzimidazole (adenine) phosphoribosyltransferase activity" EXACT [EC:2.4.2.21]
synonym: "nicotinate-nucleotide:5,6-dimethylbenzimidazole phospho-D-ribosyltransferase activity" EXACT [EC:2.4.2.21]
synonym: "nicotinate-nucleotide:dimethylbenzimidazole phospho-D-ribosyltransferase activity" EXACT [EC:2.4.2.21]
xref: EC:2.4.2.21
xref: KEGG:R04148
xref: MetaCyc:DMBPPRIBOSYLTRANS-RXN
xref: RHEA:11199
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0008940
name: nitrate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: nitrite + acceptor = nitrate + reduced acceptor." [EC:1.7.99.4]
subset: gosubset_prok
synonym: "nitrate reductase (acceptor)" EXACT [EC:1.7.99.4]
synonym: "nitrite:(acceptor) oxidoreductase" EXACT [EC:1.7.99.4]
synonym: "nitrite:acceptor oxidoreductase" EXACT [EC:1.7.99.4]
synonym: "respiratory nitrate reductase activity" NARROW [EC:1.7.99.4]
xref: EC:1.7.99.4
xref: MetaCyc:NITRATREDUCT-RXN
xref: RHEA:21071
is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors

[Term]
id: GO:0008941
name: nitric oxide dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 NO + 2 O2 + NADPH + H+ = 2 nitrate + NADP+." [EC:1.14.12.17]
subset: gosubset_prok
synonym: "nitric oxide,NAD(P)H:oxygen oxidoreductase activity" EXACT [EC:1.14.12.17]
synonym: "NOD activity" EXACT [EC:1.14.12.17]
xref: EC:1.14.12.17
xref: MetaCyc:R621-RXN
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0008942
name: nitrite reductase [NAD(P)H] activity
namespace: molecular_function
def: "Catalysis of the reaction: ammonium hydroxide + 3 NAD(P)+ + H2O = nitrite + 3 NAD(P)H + 3 H+." [EC:1.7.1.4]
comment: Note that this function was formerly EC:1.6.6.4.
subset: gosubset_prok
synonym: "ammonium-hydroxide:NAD(P)+ oxidoreductase activity" EXACT [EC:1.7.1.4]
synonym: "assimilatory nitrite reductase activity" RELATED [EC:1.7.1.4]
synonym: "NAD(P)H2:nitrite oxidoreductase activity" EXACT [EC:1.7.1.4]
synonym: "NAD(P)H:nitrite oxidoreductase activity" EXACT [EC:1.7.1.4]
synonym: "NADH-nitrite oxidoreductase activity" EXACT [EC:1.7.1.4]
synonym: "NADPH-nitrite reductase activity" EXACT [EC:1.7.1.4]
synonym: "nitrite reductase (reduced nicotinamide adenine dinucleotide (phosphate)) activity" EXACT [EC:1.7.1.4]
synonym: "nitrite reductase [NAD(P)H2]" RELATED [EC:1.7.1.4]
xref: EC:1.7.1.4
xref: KEGG:R00787
xref: KEGG:R00789
xref: MetaCyc:NITRITREDUCT-RXN
xref: RHEA:24631
xref: RHEA:24635
is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor
is_a: GO:0098809 ! nitrite reductase activity

[Term]
id: GO:0008943
name: obsolete glyceraldehyde-3-phosphate dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reactions: glyceraldehyde 3-phosphate + phosphate + NAD(P)+ = 3-phospho-D-glyceroyl-phosphate + NAD(P)H + H+, and glyceraldehyde 3-phosphate + H2O + NAD(P)+ = 3-phospho-D-glycerate + NAD(P)H + H+." [EC:1.2.1.12, EC:1.2.1.13, EC:1.2.1.9]
comment: This term was made obsolete because it is a grouping term based on similar names.
synonym: "glyceraldehyde-3-phosphate dehydrogenase activity" EXACT []
is_obsolete: true
consider: GO:0004365
consider: GO:0008886
consider: GO:0043878
consider: GO:0047100

[Term]
id: GO:0008944
name: obsolete oligopeptidase A activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-Gly-Pro-Ala is cleaved at the Gly-Gly bond, but not Z-(Gly)5." [EC:3.4.24.70]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "68000-M signalpeptide hydrolase activity" EXACT [EC:3.4.24.70]
synonym: "oligopeptidase A activity" EXACT []
xref: EC:3.4.24.70
xref: MetaCyc:3.4.24.70-RXN
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0008945
name: obsolete oligopeptidase B activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of Arg-Xaa and Lys-Xaa bonds in oligopeptides, even when P1' residue is proline." [EC:3.4.21.83]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "Escherichia coli alkaline proteinase II" RELATED [EC:3.4.21.83]
synonym: "oligopeptidase B activity" EXACT []
synonym: "protease II activity" EXACT [EC:3.4.21.83]
xref: EC:3.4.21.83
xref: MetaCyc:3.4.21.83-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0008946
name: oligonucleotidase activity
namespace: molecular_function
def: "Catalysis of the exonucleolytic cleavage of oligonucleotides to yield nucleoside 5'-phosphates." [EC:3.1.13.3]
comment: Note that enzymes with this activity usually also hydrolyze NAD+ to NMN and AMP.
subset: gosubset_prok
xref: EC:3.1.13.3
xref: MetaCyc:3.1.13.3-RXN
is_a: GO:0004518 ! nuclease activity

[Term]
id: GO:0008947
name: obsolete omptin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the preferential cleavage of Xaa-Yaa in which both Xaa and Yaa are Arg or Lys." [EC:3.4.21.87]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "omptin activity" EXACT []
xref: EC:3.4.21.87
xref: MetaCyc:3.4.21.87-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0008948
name: oxaloacetate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: oxaloacetate = pyruvate + CO2." [EC:1.1.1.38, EC:1.1.1.40, EC:4.1.1.3]
subset: gosubset_prok
synonym: "oxalacetic acid decarboxylase activity" EXACT [EC:4.1.1.3]
synonym: "oxalate beta-decarboxylase activity" EXACT [EC:4.1.1.3]
synonym: "oxaloacetate beta-decarboxylase activity" EXACT [EC:4.1.1.3]
synonym: "oxaloacetate carboxy-lyase (pyruvate-forming)" EXACT [EC:4.1.1.3]
synonym: "oxaloacetate carboxy-lyase activity" EXACT [EC:4.1.1.3]
xref: EC:1.1.1.38
xref: EC:1.1.1.40
xref: EC:4.1.1.3
xref: KEGG:R00217
xref: MetaCyc:OXALODECARB-RXN
xref: RHEA:15644
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0008949
name: oxalyl-CoA decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(+) + oxalyl-CoA = CO(2) + formyl-CoA." [EC:4.1.1.8, RHEA:19336]
subset: gosubset_prok
synonym: "oxalyl coenzyme A decarboxylase activity" EXACT [EC:4.1.1.8]
synonym: "oxalyl-CoA carboxy-lyase (formyl-CoA-forming)" EXACT [EC:4.1.1.8]
synonym: "oxalyl-CoA carboxy-lyase activity" EXACT [EC:4.1.1.8]
xref: EC:4.1.1.8
xref: KEGG:R01908
xref: MetaCyc:OXALYL-COA-DECARBOXYLASE-RXN
xref: RHEA:19336
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0008950
name: obsolete p-aminobenzoate synthetase
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:krc]
comment: This term was made obsolete because it refers to two different functions, a glutamine amidotransferase that functions as an aminodeoxychorismate synthase [itself composed of two enzymatic activities, a glutaminase and a chorismate aminase (this latter is sometimes referred to as the aminodeoxychorismate synthase)] and a 4-amino-4-deoxychorismate aromatase (4-amino-4-deoxychorismate lyase). Note that the name 'para-amino benzoate synthase' was initially given to the 'aminodeoxychorismate synthase' activity before the additional lyase activity was discovered.
synonym: "p-aminobenzoate synthetase" EXACT []
is_obsolete: true
consider: GO:0008696
consider: GO:0046820

[Term]
id: GO:0008951
name: palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a palmitoleoyl-[acyl-carrier protein] + alpha-KDO-(2->4)-alpha-KDO-(2->6)-lipid IVA = KDO2-(palmitoleoyl)-lipid IVA + a holo-[acyl-carrier protein]." [MetaCyc:PALMITOTRANS-RXN]
synonym: "palmitoleoyl ACP-dependent acyltransferase activity" EXACT []
xref: EC:2.3.1.-
xref: MetaCyc:PALMITOTRANS-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0008953
name: penicillin amidase activity
namespace: molecular_function
def: "Catalysis of the reaction: penicillin + H2O = a carboxylate + 6-aminopenicillanate." [EC:3.5.1.11]
subset: gosubset_prok
synonym: "alpha-acylamino-beta-lactam acylhydrolase activity" EXACT [EC:3.5.1.11]
synonym: "ampicillin acylase activity" EXACT [EC:3.5.1.11]
synonym: "benzylpenicillin acylase activity" EXACT [EC:3.5.1.11]
synonym: "novozym 217" RELATED [EC:3.5.1.11]
synonym: "palmitoleoyl [acyl-carrier protein]-dependent acyltransferase activity" EXACT []
synonym: "penicillin acylase activity" EXACT [EC:3.5.1.11]
synonym: "penicillin amidohydrolase activity" EXACT [EC:3.5.1.11]
synonym: "semacylase activity" EXACT [EC:3.5.1.11]
xref: EC:3.5.1.11
xref: MetaCyc:PENICILLIN-AMIDASE-RXN
xref: RHEA:18696
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0008954
name: obsolete peptidoglycan synthetase activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it was not defined, is ambiguous, and has been used to annotate gene products with very different activities.
subset: gosubset_prok
synonym: "peptidoglycan synthetase activity" EXACT []
is_obsolete: true
consider: GO:0008955
consider: GO:0071972

[Term]
id: GO:0008955
name: peptidoglycan glycosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: [GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-diphosphoundecaprenol + GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = [GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-diphosphoundecaprenol + undecaprenyl diphosphate." [EC:2.4.1.129]
subset: gosubset_prok
synonym: "bactoprenyldiphospho-N-acetylmuramoyl-(N-acetyl-D-glucosaminyl)-pentapeptide:peptidoglycan N-acetylmuramoyl-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.129]
synonym: "penicillin binding protein (3 or 1B) activity" NARROW [EC:2.4.1.129]
synonym: "peptidoglycan TGase activity" EXACT [EC:2.4.1.129]
synonym: "peptidoglycan transglycosylase activity" EXACT [EC:2.4.1.129]
synonym: "PG-II activity" EXACT [EC:2.4.1.129]
synonym: "undecaprenyldiphospho-N-acetyl-D-glucosaminyl-(1->4)-(N-acetyl-D-muramoylpentapeptide):undecaprenyldiphospho-(N-acetyl-D-glucosaminyl-(1->4)-N-acetyl-D-muramoylpentapeptide) disaccharidetransferase activity" EXACT [EC:2.4.1.129]
xref: EC:2.4.1.129
xref: MetaCyc:RXN0-5405
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0008956
name: obsolete peptidyl-dipeptidase Dcp activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of unblocked, C-terminal dipeptides from oligopeptides, with broad specificity. Does not hydrolyze bonds in which P1' is Pro, or both P1 and P1' are Gly." [EC:3.4.15.5]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "dipeptidyl carboxypeptidase (Dcp)" EXACT [EC:3.4.15.5]
synonym: "dipeptidyl carboxypeptidase activity" EXACT [EC:3.4.15.5]
synonym: "peptidyl-dipeptidase Dcp activity" EXACT []
xref: EC:3.4.15.5
xref: MetaCyc:3.4.15.5-RXN
is_obsolete: true
consider: GO:0008235
consider: GO:0008241

[Term]
id: GO:0008957
name: phenylacetaldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenylacetaldehyde + NAD+ + H2O = phenylacetate + NADH + H+." [EC:1.2.1.39]
subset: gosubset_prok
synonym: "phenylacetaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.39]
xref: EC:1.2.1.39
xref: MetaCyc:PHENDEHYD-RXN
xref: RHEA:21395
xref: UM-BBD_reactionID:r0035
is_a: GO:0004029 ! aldehyde dehydrogenase (NAD) activity

[Term]
id: GO:0008959
name: phosphate acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + phosphate = CoA + acetyl phosphate." [EC:2.3.1.8]
subset: gosubset_prok
synonym: "acetyl-CoA:phosphate acetyltransferase activity" EXACT [EC:2.3.1.8]
synonym: "phosphoacylase activity" EXACT [EC:2.3.1.8]
synonym: "phosphotransacetylase activity" EXACT [EC:2.3.1.8]
synonym: "PTA" RELATED [EC:2.3.1.8]
xref: EC:2.3.1.8
xref: MetaCyc:PHOSACETYLTRANS-RXN
xref: RHEA:19524
is_a: GO:0016407 ! acetyltransferase activity

[Term]
id: GO:0008960
name: phosphatidylglycerol-membrane-oligosaccharide glycerophosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphatidylglycerol + membrane-derived-oligosaccharide D-glucose = 1,2-diacyl-sn-glycerol + membrane-derived-oligosaccharide 6-(glycerophospho)-D-glucose." [EC:2.7.8.20]
subset: gosubset_prok
synonym: "oligosaccharide glycerophosphotransferase activity" EXACT [EC:2.7.8.20]
synonym: "phosphatidylglycerol:membrane-derived-oligosaccharide-D-glucose glycerophosphotransferase activity" EXACT [EC:2.7.8.20]
synonym: "phosphoglycerol transferase activity" RELATED [EC:2.7.8.20]
synonym: "phosphoglycerol transferase I" RELATED [EC:2.7.8.20]
xref: EC:2.7.8.20
xref: MetaCyc:PGLYCEROLTRANSI-RXN
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0008961
name: phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity
namespace: molecular_function
def: "Catalysis of the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the prospective N-terminal cysteine residue in an unmodified prolipoprotein." [PMID:8051048]
subset: gosubset_prok
is_a: GO:0016757 ! transferase activity, transferring glycosyl groups

[Term]
id: GO:0008962
name: phosphatidylglycerophosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate." [EC:3.1.3.27]
subset: gosubset_prok
synonym: "PGP phosphatase activity" EXACT [EC:3.1.3.27]
synonym: "phosphatidylglycerol phosphatase activity" EXACT [EC:3.1.3.27]
synonym: "phosphatidylglycerol phosphate phosphatase activity" EXACT [EC:3.1.3.27]
synonym: "phosphatidylglycerophosphate phosphohydrolase activity" EXACT [EC:3.1.3.27]
xref: EC:3.1.3.27
xref: MetaCyc:PGPPHOSPHA-RXN
xref: RHEA:16728
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0008963
name: phospho-N-acetylmuramoyl-pentapeptide-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + undecaprenyl phosphate = UMP + N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine-diphosphoundecaprenol." [EC:2.7.8.13]
comment: Note that EC classifies 'UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity ; GO:0051992' and 'phospho-N-acetylmuramoyl-pentapeptide-transferase activity ; GO:0008963' under the same EC number, EC:2.7.8.13.
subset: goslim_chembl
subset: gosubset_prok
synonym: "MraY transferase activity" NARROW [EC:2.7.8.13]
synonym: "phospho-MurNAc-pentapeptide transferase activity" EXACT [EC:2.7.8.13]
synonym: "phospho-N-acetylmuramoyl pentapeptide translocase activity" EXACT [EC:2.7.8.13]
synonym: "phospho-NAc-muramoyl-pentapeptide translocase (UMP) activity" EXACT [EC:2.7.8.13]
synonym: "phosphoacetylmuramoylpentapeptide translocase activity" EXACT [EC:2.7.8.13]
synonym: "phosphoacetylmuramoylpentapeptidetransferase activity" EXACT [EC:2.7.8.13]
synonym: "UDP-MurAc(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala):undecaprenyl-phosphate phospho-N-acetylmuramoyl-pentapeptide-transferase activity" EXACT [EC:2.7.8.13]
synonym: "UDP-MurNAc-Ala-gamma-DGlu-Lys-DAla-DAla:undecaprenylphosphate transferase activity" EXACT [EC:2.7.8.13]
synonym: "UDP-MurNAc-Ala-gammaDGlu-Lys-DAla-DAla:undecaprenylphosphate transferase activity" EXACT [EC:2.7.8.13]
synonym: "UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala:C(55)-isoprenoid alcohol transferase activity" EXACT [EC:2.7.8.13]
synonym: "UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala:C55-isoprenoid alcohol transferase activity" EXACT [EC:2.7.8.13]
synonym: "UDP-MurNAc-pentapeptide phosphotransferase activity" EXACT [EC:2.7.8.13]
xref: EC:2.7.8.13
xref: MetaCyc:RXN-8975
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0008964
name: phosphoenolpyruvate carboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphate + oxaloacetate = phosphoenolpyruvate + HCO3-." [EC:4.1.1.31]
subset: gosubset_prok
synonym: "PEP carboxylase activity" EXACT [EC:4.1.1.31]
synonym: "PEPC" RELATED [EC:4.1.1.31]
synonym: "PEPCase activity" EXACT [EC:4.1.1.31]
synonym: "phosphate:oxaloacetate carboxy-lyase (adding phosphate; phosphoenolpyruvate-forming)" EXACT [EC:4.1.1.31]
synonym: "phosphate:oxaloacetate carboxy-lyase (phosphorylating)" EXACT [EC:4.1.1.31]
synonym: "phosphoenolpyruvic carboxylase activity" EXACT [EC:4.1.1.31]
synonym: "phosphopyruvate (phosphate) carboxylase activity" EXACT [EC:4.1.1.31]
xref: EC:4.1.1.31
xref: KEGG:R00345
xref: MetaCyc:PEPCARBOX-RXN
xref: RHEA:28373
is_a: GO:0004611 ! phosphoenolpyruvate carboxykinase activity

[Term]
id: GO:0008965
name: phosphoenolpyruvate-protein phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphoenolpyruvate + protein L-histidine = pyruvate + protein N(pi)-phospho-L-histidine." [EC:2.7.3.9]
subset: gosubset_prok
synonym: "enzyme I of the phosphotransferase system" NARROW [EC:2.7.3.9]
synonym: "phosphoenolpyruvate sugar phosphotransferase enzyme I activity" EXACT [EC:2.7.3.9]
synonym: "phosphoenolpyruvate--protein phosphatase activity" EXACT [EC:2.7.3.9]
synonym: "phosphoenolpyruvate:protein-L-histidine N-pros-phosphotransferase activity" EXACT [EC:2.7.3.9]
synonym: "phosphoenolpyruvate:protein-L-histidine Npi-phosphotransferase activity" EXACT [EC:2.7.3.9]
synonym: "phosphopyruvate--protein factor phosphotransferase activity" EXACT [EC:2.7.3.9]
synonym: "phosphopyruvate--protein phosphotransferase activity" EXACT [EC:2.7.3.9]
synonym: "sugar--PEP phosphotransferase enzyme I activity" NARROW [EC:2.7.3.9]
xref: EC:2.7.3.9
xref: MetaCyc:2.7.3.9-RXN
is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor

[Term]
id: GO:0008966
name: phosphoglucosamine mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate." [EC:5.4.2.10, RHEA:23427]
subset: gosubset_prok
synonym: "alpha-D-glucosamine 1,6-phosphomutase activity" EXACT [EC:5.4.2.10]
synonym: "D-glucosamine 1,6-phosphomutase activity" EXACT [EC:5.4.2.10]
xref: EC:5.4.2.10
xref: KEGG:R02060
xref: MetaCyc:5.4.2.10-RXN
xref: RHEA:23427
is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases

[Term]
id: GO:0008967
name: phosphoglycolate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-phosphoglycolate + H(2)O = glycolate + phosphate." [EC:3.1.3.18, RHEA:14372]
subset: gosubset_prok
synonym: "2-phosphoglycolate phosphatase activity" EXACT [EC:3.1.3.18]
synonym: "2-phosphoglycolate phosphohydrolase activity" EXACT [EC:3.1.3.18]
synonym: "P-glycolate phosphatase activity" EXACT [EC:3.1.3.18]
synonym: "phosphoglycolate hydrolase activity" EXACT [EC:3.1.3.18]
synonym: "phosphoglycollate phosphatase activity" EXACT [EC:3.1.3.18]
xref: EC:3.1.3.18
xref: KEGG:R01334
xref: MetaCyc:GPH-RXN
xref: RHEA:14372
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0008968
name: D-sedoheptulose 7-phosphate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-sedoheptulose-7-phosphate = D-alpha,beta-D-heptose 7-phosphate." [MetaCyc:RXN0-4301, PMID:11279237, PMID:8631969]
subset: gosubset_prok
synonym: "phosphoheptose isomerase activity" EXACT []
xref: MetaCyc:RXN0-4301
is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases

[Term]
id: GO:0008969
name: phosphohistidine phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphohistidine + H2O = histidine + phosphate." [GOC:mah]
comment: Note that this term applies only to free amino acids. Consider 'protein histidine phosphatase activity' if you want to annotate the phospho protein instead. See discussion at https://github.com/geneontology/go-ontology/issues/12183
subset: gosubset_prok
xref: EC:3.1.3.-
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0008970
name: phosphatidylcholine 1-acylhydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.32]
subset: goslim_chembl
subset: gosubset_prok
synonym: "phospholipase A1 activity" EXACT [EC:3.1.1.32]
xref: EC:3.1.1.32
xref: MetaCyc:PHOSPHOLIPASE-A1-RXN
is_a: GO:0004620 ! phospholipase activity
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0008972
name: phosphomethylpyrimidine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine." [EC:2.7.4.7]
subset: gosubset_prok
synonym: "ATP:4-amino-2-methyl-5-phosphomethylpyrimidine phosphotransferase activity" EXACT [EC:2.7.4.7]
synonym: "hydroxymethylpyrimidine phosphokinase activity" EXACT [EC:2.7.4.7]
xref: EC:2.7.4.7
xref: MetaCyc:PYRIMSYN3-RXN
xref: RHEA:19896
is_a: GO:0016301 ! kinase activity
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor

[Term]
id: GO:0008973
name: phosphopentomutase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-ribose 1-phosphate = D-ribose 5-phosphate." [EC:5.4.2.7]
subset: gosubset_prok
synonym: "alpha-D-glucose-1,6-bisphosphate:deoxy-D-ribose-1-phosphate phosphotransferase activity" EXACT [EC:5.4.2.7]
synonym: "alpha-D-ribose 1,5-phosphomutase activity" EXACT [EC:5.4.2.7]
synonym: "D-ribose 1,5-phosphomutase activity" EXACT [EC:5.4.2.7]
synonym: "deoxyribomutase activity" RELATED [EC:5.4.2.7]
synonym: "deoxyribose phosphomutase activity" RELATED [EC:5.4.2.7]
synonym: "phosphodeoxyribomutase activity" RELATED [EC:5.4.2.7]
synonym: "phosphoribomutase activity" EXACT [EC:5.4.2.7]
xref: EC:5.4.2.7
xref: MetaCyc:PPENTOMUT-RXN
xref: RHEA:18796
is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases

[Term]
id: GO:0008974
name: phosphoribulokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-ribulose 5-phosphate + ATP = D-ribulose 1,5-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.19, RHEA:19368]
subset: gosubset_prok
synonym: "5-phosphoribulose kinase activity" EXACT [EC:2.7.1.19]
synonym: "ATP:D-ribulose-5-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.19]
synonym: "phosphopentokinase activity" RELATED [EC:2.7.1.19]
synonym: "phosphoribulokinase (phosphorylating)" EXACT [EC:2.7.1.19]
synonym: "PKK" RELATED [EC:2.7.1.19]
synonym: "PRK" RELATED [EC:2.7.1.19]
synonym: "PRuK" RELATED [EC:2.7.1.19]
synonym: "ribulose phosphate kinase activity" EXACT [EC:2.7.1.19]
synonym: "ribulose-5-phosphate kinase activity" EXACT [EC:2.7.1.19]
xref: EC:2.7.1.19
xref: KEGG:R01523
xref: MetaCyc:PHOSPHORIBULOKINASE-RXN
xref: RHEA:19368
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0008975
name: obsolete pitrilysin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the preferential cleavage of Tyr16-Leu17 and Phe25-Tyr26 bonds of oxidized insulin B chain. Also acts on other substrates of Molecular weight less than 7 kDa such as insulin and glucagon." [EC:3.4.24.55]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "Escherichia coli metalloproteinase Pi" RELATED [EC:3.4.24.55]
synonym: "Escherichia coli protease III" RELATED [EC:3.4.24.55]
synonym: "pitrilysin activity" EXACT []
synonym: "protease III activity" EXACT [EC:3.4.24.55]
synonym: "protease Pi activity" EXACT [EC:3.4.24.55]
synonym: "proteinase Pi" RELATED [EC:3.4.24.55]
synonym: "PTR" RELATED [EC:3.4.24.55]
xref: EC:3.4.24.55
xref: MetaCyc:3.4.24.55-RXN
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0008976
name: polyphosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + phosphate(n) = ADP + phosphate(n+1)." [EC:2.7.4.1]
subset: gosubset_prok
synonym: "ATP-polyphosphate phosphotransferase activity" EXACT [EC:2.7.4.1]
synonym: "ATP:polyphosphate phosphotransferase activity" EXACT [EC:2.7.4.1]
synonym: "polyphosphate polymerase activity" EXACT [GOC:curators]
synonym: "polyphosphoric acid kinase activity" EXACT [EC:2.7.4.1]
xref: EC:2.7.4.1
xref: MetaCyc:POLYPHOSPHATE-KINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor

[Term]
id: GO:0008977
name: prephenate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(+) + prephenate = (4-hydroxyphenyl)pyruvate + CO(2) + NADH." [EC:1.3.1.12, RHEA:13872]
subset: gosubset_prok
synonym: "chorismate mutase--prephenate dehydrogenase activity" EXACT [EC:1.3.1.12]
synonym: "hydroxyphenylpyruvate synthase activity" BROAD [EC:1.3.1.12]
synonym: "prephenate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.3.1.12]
xref: EC:1.3.1.12
xref: KEGG:R01728
xref: MetaCyc:PREPHENATEDEHYDROG-RXN
xref: RHEA:13872
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008978
name: obsolete prepilin peptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of a Gly-Phe bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine." [EC:3.4.23.43]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "prepilin peptidase activity" EXACT []
xref: EC:3.4.23.43
xref: MetaCyc:3.4.23.43-RXN
is_obsolete: true
replaced_by: GO:0004190

[Term]
id: GO:0008979
name: prophage integrase activity
namespace: molecular_function
def: "Catalysis of the integration of prophage DNA into a target DNA molecule, usually a bacterial chromosome, via a sequence-specific recombination event which involves the formation of an intasome, a DNA-protein-complex designed for site-specific recombination of the phage and host DNA." [GOC:jl]
subset: gosubset_prok
synonym: "integrase activity involved in establishment of integrated proviral latency" EXACT []
is_a: GO:0008907 ! integrase activity
is_a: GO:0009009 ! site-specific recombinase activity
relationship: part_of GO:0075713 ! establishment of integrated proviral latency

[Term]
id: GO:0008980
name: propionate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + propanoate = ADP + propanoyl phosphate." [EC:2.7.2.15]
subset: gosubset_prok
synonym: "ATP:propanoate phosphotransferase activity" EXACT []
synonym: "PduW" RELATED []
synonym: "propanoate kinase activity" EXACT []
synonym: "TdcD" RELATED []
xref: EC:2.7.2.15
is_a: GO:0016301 ! kinase activity
is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor

[Term]
id: GO:0008981
name: obsolete protease IV activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "protease IV activity" EXACT []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0008982
name: protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
namespace: molecular_function
alt_id: GO:0015455
alt_id: GO:0015456
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [EC:2.7.1.69, GOC:mtg_transport, http://www.ucs.mun.ca/~n55lrb/general_pts.html, ISBN:0815340729, TC:4.A.-.-.-]
subset: gosubset_prok
synonym: "enzyme II of the phosphotransferase system" NARROW [EC:2.7.1.69]
synonym: "enzyme IIl4ac" RELATED [EC:2.7.1.69]
synonym: "gene bglC RNA formation factors" RELATED [EC:2.7.1.69]
synonym: "gene glC proteins" RELATED [EC:2.7.1.69]
synonym: "group translocator activity" RELATED [EC:2.7.1.69]
synonym: "PEP--sugar phosphotransferase enzyme II activity" NARROW [EC:2.7.1.69]
synonym: "PEP-dependent phosphotransferase enzyme II" RELATED [EC:2.7.1.69]
synonym: "phosphoenolpyruvate-sugar phosphotransferase enzyme II" RELATED [EC:2.7.1.69]
synonym: "phosphohistidinoprotein-hexose phosphoribosyltransferase activity" EXACT [EC:2.7.1.69]
synonym: "phosphohistidinoprotein-hexose phosphotransferase activity" EXACT [EC:2.7.1.69]
synonym: "phosphoprotein factor-hexose phosophotransferase activity" EXACT [EC:2.7.1.69]
synonym: "phosphotransfer-driven group translocator" EXACT []
synonym: "phosphotransferase, phosphohistidinoprotein-hexose activity" EXACT [EC:2.7.1.69]
synonym: "protein, specific or class, gene bglC" RELATED [EC:2.7.1.69]
synonym: "protein-Np-phosphohistidine-sugar phosphotransferase activity" EXACT []
synonym: "protein-Npi-phospho-L-histidine:sugar N-pros-phosphotransferase activity" EXACT [EC:2.7.1.69]
synonym: "protein-Npi-phospho-L-histidine:sugar Npi-phosphotransferase activity" EXACT [EC:2.7.1.69]
synonym: "protein-Npi-phosphohistidine-sugar phosphotransferase activity" EXACT [EC:2.7.1.69]
synonym: "protein-Npi-phosphohistidine:sugar N-pros-phosphotransferase activity" EXACT [EC:2.7.1.69]
synonym: "PTS permease activity" EXACT [EC:2.7.1.69]
synonym: "PTS transporter" RELATED [EC:2.7.1.69]
synonym: "ribonucleic acid formation factor, gene glC" RELATED [EC:2.7.1.69]
synonym: "sucrose phosphotransferase system II" RELATED [EC:2.7.1.69]
xref: EC:2.7.1.69
xref: MetaCyc:2.7.1.69-RXN
is_a: GO:0015144 ! carbohydrate transmembrane transporter activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0022804 ! active transmembrane transporter activity

[Term]
id: GO:0008983
name: protein-glutamate O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + protein L-glutamate = S-adenosyl-L-homocysteine + protein L-glutamate 5-methyl ester; this reaction is the methylation of peptidyl-L-glutamate to form peptidyl-L-glutamate 5-methyl ester." [EC:2.1.1.80, RESID:AA0072]
subset: gosubset_prok
synonym: "MCP methyltransferase I" RELATED [EC:2.1.1.80]
synonym: "MCP methyltransferase II" RELATED [EC:2.1.1.80]
synonym: "methyl-accepting chemotaxis protein methyltransferase II" RELATED [EC:2.1.1.80]
synonym: "methyl-accepting chemotaxis protein O-methyltransferase activity" NARROW [EC:2.1.1.80]
synonym: "protein carboxyl-methylase activity" EXACT [EC:2.1.1.80]
synonym: "protein carboxyl-O-methyltransferase activity" EXACT [EC:2.1.1.80]
synonym: "protein carboxylmethyltransferase II" RELATED [EC:2.1.1.80]
synonym: "protein carboxymethylase activity" EXACT [EC:2.1.1.80]
synonym: "protein carboxymethyltransferase activity" EXACT [EC:2.1.1.80]
synonym: "protein methylase II" RELATED [EC:2.1.1.80]
synonym: "protein O-methyltransferase activity" EXACT [EC:2.1.1.80]
synonym: "protein(aspartate)methyltransferase activity" EXACT [EC:2.1.1.80]
synonym: "protein(carboxyl)methyltransferase activity" EXACT [EC:2.1.1.80]
synonym: "S-adenosyl-L-methionine:protein-L-glutamate O-methyltransferase activity" EXACT [EC:2.1.1.80]
synonym: "S-adenosylmethionine-glutamyl methyltransferase activity" EXACT [EC:2.1.1.80]
synonym: "S-adenosylmethionine:protein-carboxyl O-methyltransferase activity" EXACT [EC:2.1.1.80]
xref: EC:2.1.1.80
xref: MetaCyc:CHER-RXN
xref: RESID:AA0072
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
is_a: GO:0051998 ! protein carboxyl O-methyltransferase activity

[Term]
id: GO:0008984
name: protein-glutamate methylesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein L-glutamate O(5)-methyl ester + H2O = protein L-glutamate + methanol." [EC:3.1.1.61, RESID:AA0072]
subset: gosubset_prok
synonym: "CheB methylesterase activity" NARROW [EC:3.1.1.61]
synonym: "chemotaxis-specific methylesterase activity" NARROW [EC:3.1.1.61]
synonym: "methyl-accepting chemotaxis protein methyl-esterase activity" NARROW [EC:3.1.1.61]
synonym: "methylesterase CheB activity" NARROW [EC:3.1.1.61]
synonym: "protein-L-glutamate-5-O-methyl-ester acylhydrolase activity" EXACT [EC:3.1.1.61]
synonym: "protein-L-glutamate-O5-methyl-ester acylhydrolase activity" EXACT [EC:3.1.1.61]
xref: EC:3.1.1.61
xref: MetaCyc:MCPMETEST-RXN
xref: RESID:AA0072
is_a: GO:0051723 ! protein methylesterase activity

[Term]
id: GO:0008985
name: obsolete pyruvate dehydrogenase (cytochrome) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: pyruvate + ferricytochrome b1 + H2O = CO2 + acetate + ferrocytochrome b1." [EC:1.2.2.2]
comment: This term was made obsolete because the EC activity it represents, EC:1.2.2.2, has been deleted.
subset: gosubset_prok
synonym: "pyruvate dehydrogenase (cytochrome) activity" EXACT []
synonym: "pyruvate:ferricytochrome-b1 oxidoreductase activity" RELATED [EC:1.2.2.2]
synonym: "pyruvate:ubiquinone-8-oxidoreductase activity" RELATED [EC:1.2.2.2]
synonym: "pyruvic (cytochrome b1) dehydrogenase activity" RELATED [EC:1.2.2.2]
is_obsolete: true
replaced_by: GO:0052737

[Term]
id: GO:0008986
name: pyruvate, water dikinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H(2)O + pyruvate = AMP + 3 H(+) + phosphate + phosphoenolpyruvate." [EC:2.7.9.2, RHEA:11367]
subset: gosubset_prok
synonym: "ATP:pyruvate, water phosphotransferase activity" EXACT [EC:2.7.9.2]
synonym: "PEP synthase activity" EXACT []
synonym: "PEP synthetase activity" EXACT [EC:2.7.9.2]
synonym: "phoephoenolpyruvate synthetase activity" EXACT [EC:2.7.9.2]
synonym: "phosphoenolpyruvate synthase activity" EXACT [EC:2.7.9.2]
synonym: "phosphoenolpyruvic synthase activity" EXACT [EC:2.7.9.2]
synonym: "phosphopyruvate synthetase activity" EXACT [EC:2.7.9.2]
synonym: "pyruvate,water dikinase activity" EXACT [EC:2.7.9.2]
synonym: "pyruvate-water dikinase (phosphorylating)" EXACT [EC:2.7.9.2]
synonym: "water pyruvate dikinase activity" EXACT []
xref: EC:2.7.9.2
xref: KEGG:R00199
xref: MetaCyc:PEPSYNTH-RXN
xref: RHEA:11367
is_a: GO:0016301 ! kinase activity
is_a: GO:0016781 ! phosphotransferase activity, paired acceptors

[Term]
id: GO:0008987
name: quinolinate synthetase A activity
namespace: molecular_function
def: "Catalysis of the reaction: iminoaspartate + dihydroxy-acetone-phosphate = quinolinate + 2 H2O + phosphate." [GOC:jl, MetaCyc:QUINOLINATE-SYNTHA-RXN]
subset: gosubset_prok
xref: MetaCyc:QUINOLINATE-SYNTHA-RXN
is_a: GO:0003824 ! catalytic activity
relationship: part_of GO:0019805 ! quinolinate biosynthetic process

[Term]
id: GO:0008988
name: rRNA (adenine-N6-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N6-methyladenine." [EC:2.1.1.48]
subset: gosubset_prok
synonym: "ErmC 23S rRNA methyltransferase" NARROW [EC:2.1.1.48]
synonym: "gene ksgA methyltransferase" NARROW [EC:2.1.1.48]
synonym: "ribonucleic acid-adenine (N(6)) methylase activity" EXACT [EC:2.1.1.48]
synonym: "ribonucleic acid-adenine (N6) methylase activity" EXACT [EC:2.1.1.48]
synonym: "ribosomal ribonucleate adenine 6-methyltransferase activity" EXACT [EC:2.1.1.48]
synonym: "S-adenosyl-L-methionine:rRNA (adenine-6-N-)-methyltransferase activity" EXACT [EC:2.1.1.48]
synonym: "S-adenosyl-L-methionine:rRNA (adenine-N6-)-methyltransferase activity" EXACT [EC:2.1.1.48]
xref: EC:2.1.1.-
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0016433 ! rRNA (adenine) methyltransferase activity

[Term]
id: GO:0008989
name: rRNA (guanine-N1-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N1-methylguanine." [EC:2.1.1.51]
subset: gosubset_prok
synonym: "ribosomal ribonucleate guanine 1-methyltransferase activity" EXACT [EC:2.1.1.51]
synonym: "S-adenosyl-L-methionine:rRNA (guanine-1-N-)-methyltransferase activity" EXACT [EC:2.1.1.51]
synonym: "S-adenosyl-L-methionine:rRNA (guanine-N1-)-methyltransferase activity" EXACT [EC:2.1.1.51]
xref: EC:2.1.1.51
xref: MetaCyc:RRNA-GUANINE-N1--METHYLTRANSFERASE-RXN
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0016435 ! rRNA (guanine) methyltransferase activity

[Term]
id: GO:0008990
name: rRNA (guanine-N2-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N2-methylguanine." [EC:2.1.1.52]
subset: gosubset_prok
synonym: "ribosomal ribonucleate guanine-2-methyltransferase activity" EXACT [EC:2.1.1.52]
synonym: "S-adenosyl-L-methionine:rRNA (guanine-2-N-)-methyltransferase activity" EXACT [EC:2.1.1.52]
synonym: "S-adenosyl-L-methionine:rRNA (guanine-N2-)-methyltransferase activity" EXACT [EC:2.1.1.52]
xref: EC:2.1.1.52
xref: MetaCyc:RRNA-GUANINE-N2--METHYLTRANSFERASE-RXN
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0016435 ! rRNA (guanine) methyltransferase activity

[Term]
id: GO:0008991
name: obsolete serine-type signal peptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of a signal peptide from a protein precursor by a serine endopeptidase mechanism." [GOC:mah]
comment: This term was made obsolete because 'signal peptide' is difficult to define unambiguously, and because the term refers to gene products.
synonym: "serine-type signal peptidase activity" EXACT []
xref: EC:3.4.21.-
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0008992
name: obsolete repressor LexA activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of Ala-Gly bond in repressor lexA." [EC:3.4.21.88]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "LexA repressor" RELATED [EC:3.4.21.88]
synonym: "repressor lexA" RELATED [EC:3.4.21.88]
synonym: "repressor LexA activity" EXACT []
xref: EC:3.4.21.88
xref: MetaCyc:3.4.21.88-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0008993
name: rhamnulokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-rhamnulose = ADP + L-rhamnulose 1-phosphate." [EC:2.7.1.5]
subset: gosubset_prok
synonym: "ATP:L-rhamnulose 1-phosphotransferase activity" EXACT [EC:2.7.1.5]
synonym: "L-rhamnulokinase activity" EXACT [EC:2.7.1.5]
synonym: "L-rhamnulose kinase activity" EXACT [EC:2.7.1.5]
synonym: "rhamnulokinase (phosphorylating)" EXACT [EC:2.7.1.5]
synonym: "rhamnulose kinase activity" EXACT [EC:2.7.1.5]
synonym: "RhuK" RELATED [EC:2.7.1.5]
xref: EC:2.7.1.5
xref: MetaCyc:RHAMNULOKIN-RXN
xref: RHEA:20120
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0008994
name: rhamnulose-1-phosphate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-rhamnulose 1-phosphate = glycerone phosphate + (S)-lactaldehyde." [EC:4.1.2.19]
subset: gosubset_prok
synonym: "L-rhamnulose 1-phosphate aldolase activity" EXACT [EC:4.1.2.19]
synonym: "L-rhamnulose-1-phosphate lactaldehyde-lyase activity" EXACT [EC:4.1.2.19]
synonym: "L-rhamnulose-1-phosphate S-lactaldehyde-lyase (glycerone-phosphate-forming)" EXACT [EC:4.1.2.19]
synonym: "L-rhamnulose-phosphate aldolase activity" EXACT [EC:4.1.2.19]
synonym: "rhamnulose phosphate aldolase activity" EXACT [EC:4.1.2.19]
xref: EC:4.1.2.19
xref: MetaCyc:RHAMNULPALDOL-RXN
xref: RHEA:19692
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0008995
name: ribonuclease E activity
namespace: molecular_function
def: "Catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5'-end; cleavage occurs predominantly at 5 nucleotides from the 5'-end and in A + U-rich regions, and is blocked by the presence of a 5'-triphosphate group." [PMID:10722715, PMID:16854990]
subset: gosubset_prok
xref: MetaCyc:3.1.26.12-RXN
is_a: GO:0004540 ! ribonuclease activity

[Term]
id: GO:0008996
name: ribonuclease G activity
namespace: molecular_function
def: "Catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5'-end; cleavage occurs predominantly at positions 5 and 6 nucleotides from the 5'-end and in A + U-rich regions, and is blocked by the presence of a 5'-triphosphate group." [PMID:10722715, PMID:16854990]
subset: gosubset_prok
is_a: GO:0004540 ! ribonuclease activity

[Term]
id: GO:0008997
name: ribonuclease R activity
namespace: molecular_function
def: "Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction, leaving an undigested core of 3-5 nucleotides." [PMID:11948193]
subset: gosubset_prok
xref: EC:3.1.11.-
is_a: GO:0004540 ! ribonuclease activity

[Term]
id: GO:0008998
name: ribonucleoside-triphosphate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin." [EC:1.17.4.2]
subset: gosubset_prok
synonym: "2'-deoxyribonucleoside-triphosphate:oxidized-thioredoxin 2'-oxidoreductase activity" EXACT [EC:1.17.4.2]
synonym: "2'-deoxyribonucleoside-triphosphate:thioredoxin-disulfide 2'-oxidoreductase activity" EXACT [EC:1.17.4.2]
synonym: "ribonucleotide reductase activity" BROAD [EC:1.17.4.2]
xref: EC:1.17.4.2
xref: MetaCyc:1.17.4.2-RXN
xref: RHEA:12704
is_a: GO:0016728 ! oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor

[Term]
id: GO:0008999
name: ribosomal-protein-alanine N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + ribosomal-protein L-alanine = CoA + ribosomal-protein N-acetyl-L-alanine." [EC:2.3.1.128]
subset: gosubset_prok
synonym: "acetyl-CoA:ribosomal-protein-L-alanine N-acetyltransferase activity" EXACT [EC:2.3.1.128]
synonym: "ribosomal protein S18 acetyltransferase activity" EXACT [EC:2.3.1.128]
xref: EC:2.3.1.128
xref: MetaCyc:2.3.1.128-RXN
is_a: GO:0004596 ! peptide alpha-N-acetyltransferase activity

[Term]
id: GO:0009000
name: selenocysteine lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-selenocysteine + reduced acceptor = hydrogen selenide + L-alanine + acceptor." [EC:4.4.1.16]
subset: gosubset_prok
synonym: "L-selenocysteine selenide-lyase (L-alanine-forming)" EXACT [EC:4.4.1.16]
synonym: "selenocysteine beta-lyase activity" EXACT [EC:4.4.1.16]
synonym: "selenocysteine reductase activity" EXACT [EC:4.4.1.16]
xref: EC:4.4.1.16
xref: MetaCyc:SELENOCYSTEINE-LYASE-RXN
xref: RHEA:11635
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0009001
name: serine O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-serine + acetyl-CoA = O-acetyl-L-serine + CoA." [EC:2.3.1.30, RHEA:24563]
subset: gosubset_prok
synonym: "acetyl-CoA:L-serine O-acetyltransferase activity" EXACT [EC:2.3.1.30]
synonym: "L-serine acetyltransferase activity" EXACT [EC:2.3.1.30]
synonym: "SATase activity" EXACT [EC:2.3.1.30]
synonym: "serine acetyltransferase activity" EXACT [EC:2.3.1.30]
synonym: "serine transacetylase activity" EXACT [EC:2.3.1.30]
xref: EC:2.3.1.30
xref: KEGG:R00586
xref: MetaCyc:SERINE-O-ACETTRAN-RXN
xref: Reactome:REACT_27240 "acetylation of serine, Mycobacterium tuberculosis"
xref: RHEA:24563
is_a: GO:0016412 ! serine O-acyltransferase activity
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0009002
name: serine-type D-Ala-D-Ala carboxypeptidase activity
namespace: molecular_function
def: "Catalysis of the reaction: (Ac)2-L-Lys-D-alanyl-D-alanine + H2O = (Ac)2-L-Lys-D-alanine + D-alanine." [EC:3.4.16.4]
subset: gosubset_prok
synonym: "D-alanine carboxypeptidase" BROAD [EC:3.4.16.4]
synonym: "D-alanyl carboxypeptidase activity" EXACT [EC:3.4.16.4]
synonym: "D-alanyl-D-alanine carboxypeptidase activity" EXACT [EC:3.4.16.4]
synonym: "D-alanyl-D-alanine-carboxypeptidase activity" EXACT [EC:3.4.16.4]
synonym: "D-alanyl-D-alanine-cleaving peptidase activity" EXACT [EC:3.4.16.4]
synonym: "D-alanyl-D-alanine-cleaving-peptidase activity" EXACT [EC:3.4.16.4]
synonym: "DD-carboxypeptidase" BROAD [EC:3.4.16.4]
synonym: "DD-peptidase activity" EXACT [EC:3.4.16.4]
synonym: "DD-transpeptidase activity" EXACT [EC:3.4.16.4]
xref: EC:3.4.16.4
xref: MetaCyc:3.4.16.4-RXN
is_a: GO:0004185 ! serine-type carboxypeptidase activity

[Term]
id: GO:0009003
name: obsolete signal peptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of a signal peptide from a protein precursor." [GOC:mah]
comment: This term was made obsolete because 'signal peptide' is difficult to define unambiguously, and because the term refers to gene products.
synonym: "signal peptidase activity" EXACT []
is_obsolete: true
replaced_by: GO:0008233

[Term]
id: GO:0009004
name: obsolete signal peptidase I activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of N-terminal leader sequences from secreted and periplasmic proteins precursor." [EC:3.4.21.89]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "bacterial leader peptidase 1" RELATED [EC:3.4.21.89]
synonym: "bacterial leader peptidase I activity" NARROW [EC:3.4.21.89]
synonym: "Escherichia coli leader peptidase" NARROW [EC:3.4.21.89]
synonym: "eukaryotic signal peptidase" NARROW [EC:3.4.21.89]
synonym: "eukaryotic signal proteinase" NARROW [EC:3.4.21.89]
synonym: "HOSP" RELATED [EC:3.4.21.89]
synonym: "leader peptidase activity" EXACT [EC:3.4.21.89]
synonym: "leader peptidase I" RELATED [EC:3.4.21.89]
synonym: "leader peptide hydrolase activity" EXACT [EC:3.4.21.89]
synonym: "leader proteinase activity" EXACT [EC:3.4.21.89]
synonym: "phage-procoat-leader peptidase activity" NARROW [EC:3.4.21.89]
synonym: "pilin leader peptidase" NARROW [EC:3.4.21.89]
synonym: "prokaryotic leader peptidase" NARROW [EC:3.4.21.89]
synonym: "prokaryotic signal peptidase" NARROW [EC:3.4.21.89]
synonym: "prokaryotic signal proteinase" NARROW [EC:3.4.21.89]
synonym: "propeptidase activity" EXACT [EC:3.4.21.89]
synonym: "PuIO prepilin peptidase" NARROW [EC:3.4.21.89]
synonym: "signal peptidase I activity" EXACT []
synonym: "signal peptide hydrolase activity" EXACT [EC:3.4.21.89]
synonym: "signal proteinase activity" EXACT [EC:3.4.21.89]
synonym: "signalase activity" EXACT [EC:3.4.21.89]
synonym: "SPase I activity" EXACT [EC:3.4.21.89]
synonym: "SPC" RELATED [EC:3.4.21.89]
xref: EC:3.4.21.89
xref: MetaCyc:3.4.21.89-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0009005
name: obsolete signal peptidase II activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of N-terminal leader sequences from membrane prolipoproteins. Hydrolyzes the terminal bond of Xaa-Xbb-Xbb-Cys, in which Xaa is hydrophobic (preferably Leu), Xbb is often Ser or Ala, Xcc is often Gly or Ala, and the Cys is alkylated on sulfur with a diacylglyceryl group." [EC:3.4.23.36]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "leader peptidase II" RELATED [EC:3.4.23.36]
synonym: "lipoprotein signal peptidase activity" EXACT [EC:3.4.23.36]
synonym: "premurein leader proteinase activity" EXACT [EC:3.4.23.36]
synonym: "premurein-leader peptidase activity" NARROW [EC:3.4.23.36]
synonym: "prolipoprotein signal peptidase activity" EXACT [EC:3.4.23.36]
synonym: "prolipoprotein-signal peptidase activity" EXACT [EC:3.4.23.36]
synonym: "signal peptidase II activity" EXACT []
synonym: "SPase II activity" EXACT [EC:3.4.23.36]
xref: EC:3.4.23.36
xref: MetaCyc:3.4.23.36-RXN
is_obsolete: true
replaced_by: GO:0004190

[Term]
id: GO:0009006
name: obsolete siroheme synthase activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents three different molecular functions.
synonym: "sirohaem synthase activity" EXACT []
synonym: "siroheme synthase activity" EXACT []
is_obsolete: true
consider: GO:0004851
consider: GO:0019354
consider: GO:0043115
consider: GO:0051266

[Term]
id: GO:0009007
name: site-specific DNA-methyltransferase (adenine-specific) activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine." [EC:2.1.1.72]
subset: gosubset_prok
synonym: "DNA adenine methylase" BROAD []
synonym: "EcoRI methylase" NARROW [EC:2.1.1.37, EC:2.1.1.72]
synonym: "modification methylase activity" RELATED [EC:2.1.1.72]
synonym: "N-6 adenine-specific DNA methylase activity" EXACT [EC:2.1.1.72]
synonym: "restriction-modification system activity" RELATED [EC:2.1.1.72]
xref: EC:2.1.1.72
xref: MetaCyc:2.1.1.72-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
is_a: GO:0009008 ! DNA-methyltransferase activity
relationship: part_of GO:0032775 ! DNA methylation on adenine

[Term]
id: GO:0009008
name: DNA-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group to a DNA molecule." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "deoxyribonucleate methylase activity" EXACT [EC:2.1.1.-]
synonym: "deoxyribonucleate methyltransferase activity" EXACT [EC:2.1.1.-]
synonym: "deoxyribonucleic acid methylase activity" EXACT [EC:2.1.1.-]
synonym: "deoxyribonucleic acid methyltransferase activity" EXACT [EC:2.1.1.-]
synonym: "deoxyribonucleic acid modification methylase activity" RELATED [EC:2.1.1.-]
synonym: "DNA methylase" BROAD []
synonym: "DNA methyltransferase activity" EXACT []
synonym: "DNA transmethylase activity" EXACT [EC:2.1.1.-]
synonym: "Type II DNA methylase" RELATED [EC:2.1.1.37]
xref: EC:2.1.1.-
is_a: GO:0008168 ! methyltransferase activity
relationship: part_of GO:0006306 ! DNA methylation

[Term]
id: GO:0009009
name: site-specific recombinase activity
namespace: molecular_function
def: "Catalysis of the formation of new phosphodiester bonds between a pair of short, unique DNA target sequences." [GOC:elh]
comment: Note that this term is not a child of 'recombinase activity ; GO:0000150' because the latter represents activities that do not break or form phosphodiester bonds.
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0009010
name: sorbitol-6-phosphate 2-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-sorbitol 6-phosphate + NAD+ = D-fructose 6-phosphate + NADH + H+." [EC:1.1.1.140]
subset: gosubset_prok
synonym: "D-glucitol-6-phosphate dehydrogenase activity" EXACT [EC:1.1.1.140]
synonym: "D-sorbitol 6-phosphate dehydrogenase activity" EXACT [EC:1.1.1.140]
synonym: "D-sorbitol-6-phosphate dehydrogenase activity" EXACT [EC:1.1.1.140]
synonym: "D-sorbitol-6-phosphate:NAD+ 2-oxidoreductase activity" EXACT [EC:1.1.1.140]
synonym: "glucitol-6-phosphate dehydrogenase activity" EXACT [EC:1.1.1.140]
synonym: "ketosephosphate reductase activity" EXACT [EC:1.1.1.140]
synonym: "sorbitol-6-P-dehydrogenase activity" EXACT [EC:1.1.1.140]
xref: EC:1.1.1.140
xref: MetaCyc:SORB6PDEHYDROG-RXN
xref: RHEA:19840
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0009011
name: starch synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ADP-glucose + (1,4)-alpha-D-glucosyl(n) = ADP + (1,4)-alpha-D-glucosyl(n+1)." [EC:2.4.1.21]
subset: gosubset_prok
synonym: "adenosine diphosphate glucose-starch glucosyltransferase activity" EXACT [EC:2.4.1.21]
synonym: "adenosine diphosphoglucose-starch glucosyltransferase activity" EXACT [EC:2.4.1.21]
synonym: "ADP-glucose starch synthase activity" EXACT [EC:2.4.1.21]
synonym: "ADP-glucose transglucosylase activity" EXACT [EC:2.4.1.21]
synonym: "ADP-glucose--starch glucosyltransferase activity" EXACT [EC:2.4.1.21]
synonym: "ADP-glucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.21]
synonym: "ADPG starch synthetase activity" EXACT [EC:2.4.1.21]
synonym: "ADPG-starch glucosyltransferase activity" EXACT [EC:2.4.1.21]
synonym: "ADPglucose-starch glucosyltransferase activity" EXACT [EC:2.4.1.21]
synonym: "ADPglucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.21]
synonym: "glycogen synthase activity" EXACT [EC:2.4.1.21]
synonym: "starch (bacterial glycogen) synthase activity" NARROW [EC:2.4.1.21]
synonym: "starch synthetase activity" EXACT [EC:2.4.1.21]
xref: EC:2.4.1.21
xref: MetaCyc:GLYCOGENSYN-RXN
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0009012
name: aminoglycoside 3''-adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + streptomycin = 3''-adenylylstreptomycin + diphosphate + H(+)." [EC:2.7.7.47, RHEA:20248]
subset: gosubset_prok
synonym: "AAD (3'')" RELATED [EC:2.7.7.47]
synonym: "ATP:streptomycin 3''-adenylyltransferase activity" NARROW []
synonym: "streptomycin 3''-adenylyltransferase activity" NARROW []
xref: EC:2.7.7.47
xref: KEGG:R02226
xref: MetaCyc:STREPTOMYCIN-3-ADENYLYLTRANSFERASE-RXN
xref: RHEA:20248
is_a: GO:0034068 ! aminoglycoside nucleotidyltransferase activity

[Term]
id: GO:0009013
name: succinate-semialdehyde dehydrogenase [NAD(P)+] activity
namespace: molecular_function
def: "Catalysis of the reaction: succinate semialdehyde + NAD(P)+ + H2O = succinate + NAD(P)H + H+." [EC:1.2.1.16]
subset: gosubset_prok
synonym: "succinate semialdehyde dehydrogenase (nicotinamide adenine dinucleotide (phosphate))" EXACT [EC:1.2.1.16]
synonym: "succinate-semialdehyde:NAD(P)+ oxidoreductase activity" EXACT [EC:1.2.1.16]
xref: EC:1.2.1.16
xref: MetaCyc:SUCCSEMIALDDEHYDROG-RXN
xref: UM-BBD_reactionID:r0371
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0009014
name: succinyl-diaminopimelate desuccinylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-succinyl-LL-2,6-diaminopimelate + H(2)O = LL-2,6-diaminopimelate + succinate." [EC:3.5.1.18, RHEA:22611]
subset: gosubset_prok
synonym: "N-succinyl-L-alpha,epsilon-diaminopimelic acid deacylase activity" EXACT [EC:3.5.1.18]
synonym: "N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase activity" EXACT [EC:3.5.1.18]
xref: EC:3.5.1.18
xref: KEGG:R02734
xref: MetaCyc:SUCCDIAMINOPIMDESUCC-RXN
xref: RHEA:22611
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0009015
name: N-succinylarginine dihydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N(2)-succinyl-L-arginine + 2 H(2)O + 2 H(+) = N(2)-succinyl-L-ornithine + CO(2) + 2 NH(4)(+)." [EC:3.5.3.23, RHEA:19536]
subset: gosubset_prok
synonym: "2-N-succinyl-L-arginine iminohydrolase (decarboxylating)" EXACT [EC:3.5.3.23]
synonym: "arginine succinylhydrolase activity" EXACT []
synonym: "AruB" RELATED []
synonym: "AstB" RELATED []
synonym: "N2-succinyl-L-arginine iminohydrolase (decarboxylating)" EXACT []
synonym: "N2-succinylarginine dihydrolase activity" EXACT []
synonym: "SADH" RELATED []
synonym: "succinylarginine dihydrolase activity" EXACT []
xref: EC:3.5.3.23
xref: KEGG:R04189
xref: MetaCyc:SUCCARGDIHYDRO-RXN
xref: RHEA:19536
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0009016
name: succinyldiaminopimelate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + N-succinyl-LL-2,6-diaminopimelate = L-2-succinylamino-6-oxopimelate + L-glutamate." [EC:2.6.1.17, RHEA:11963]
subset: gosubset_prok
synonym: "N-succinyl-L-2,6-diaminoheptanedioate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.17]
synonym: "N-succinyl-L-diaminopimelic glutamic transaminase activity" EXACT [EC:2.6.1.17]
synonym: "succinyldiaminopimelate aminotransferase activity" EXACT []
synonym: "succinyldiaminopimelate transferase activity" EXACT [EC:2.6.1.17]
xref: EC:2.6.1.17
xref: KEGG:R04475
xref: MetaCyc:SUCCINYLDIAMINOPIMTRANS-RXN
xref: RHEA:11963
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0009017
name: succinylglutamate desuccinylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-succinyl-L-glutamate + H(2)O = L-glutamate + succinate." [EC:3.5.1.96, RHEA:15172]
subset: gosubset_prok
synonym: "AstE" RELATED []
synonym: "N-succinyl-L-glutamate amidohydrolase activity" EXACT [EC:3.5.1.96]
synonym: "N2-succinylglutamate desuccinylase activity" EXACT []
synonym: "SGDS" RELATED []
xref: EC:3.5.1.96
xref: KEGG:R00411
xref: MetaCyc:SUCCGLUDESUCC-RXN
xref: RHEA:15172
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0009018
name: sucrose phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: sucrose + phosphate = D-fructose + alpha-D-glucose 1-phosphate." [EC:2.4.1.7]
subset: gosubset_prok
synonym: "disaccharide glucosyltransferase activity" BROAD [EC:2.4.1.7]
synonym: "sucrose glucosyltransferase activity" EXACT [EC:2.4.1.7]
synonym: "sucrose:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.7]
xref: EC:2.4.1.7
xref: MetaCyc:SUCROSE-PHOSPHORYLASE-RXN
xref: RHEA:24051
is_a: GO:0004645 ! phosphorylase activity

[Term]
id: GO:0009019
name: tRNA (guanine-N1-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methylguanine." [EC:2.1.1.31]
subset: gosubset_prok
synonym: "S-adenosyl-L-methionine:tRNA (guanine-1-N-)-methyltransferase activity" EXACT [EC:2.1.1.31]
synonym: "S-adenosyl-L-methionine:tRNA (guanine-N1-)-methyltransferase activity" EXACT [EC:2.1.1.31]
synonym: "transfer ribonucleate guanine 1-methyltransferase activity" EXACT [EC:2.1.1.31]
synonym: "tRNA guanine 1-methyltransferase activity" EXACT [EC:2.1.1.31]
xref: EC:2.1.1.-
is_a: GO:0016423 ! tRNA (guanine) methyltransferase activity

[Term]
id: GO:0009020
name: tRNA (guanosine-2'-O-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 2'-O-methylguanosine." [EC:2.1.1.34]
subset: gosubset_prok
synonym: "S-adenosyl-L-methionine:tRNA (guanosine-2'-O-)-methyltransferase activity" EXACT [EC:2.1.1.34]
synonym: "S-adenosyl-L-methionine:tRNA guanosine-2'-O-methyltransferase activity" EXACT [EC:2.1.1.34]
synonym: "transfer ribonucleate guanosine 2'-methyltransferase activity" EXACT [EC:2.1.1.34]
synonym: "tRNA (Gm18) 2'-O-methyltransferase activity" EXACT [EC:2.1.1.34]
synonym: "tRNA (Gm18) methyltransferase activity" EXACT [EC:2.1.1.34]
synonym: "tRNA (guanosine 2')-methyltransferase activity" EXACT [EC:2.1.1.34]
synonym: "tRNA guanosine 2'-methyltransferase activity" EXACT [EC:2.1.1.34]
synonym: "tRNA guanosine-2'-O-methyltransferase activity" EXACT [EC:2.1.1.34]
xref: EC:2.1.1.34
xref: MetaCyc:2.1.1.34-RXN
is_a: GO:0016423 ! tRNA (guanine) methyltransferase activity

[Term]
id: GO:0009022
name: tRNA nucleotidyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: tRNA(n+1) + phosphate = tRNA(n) + a nucleoside diphosphate." [EC:2.7.7.56]
comment: Note that, although the enzyme to which this term refers is also known as 'ribonuclease PH', and degrades tRNA in the 3'-5' direction in vivo, the term does not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis.
subset: gosubset_prok
synonym: "phosphate-dependent exonuclease activity" RELATED [EC:2.7.7.56]
synonym: "ribonuclease PH activity" EXACT [EC:2.7.7.56]
synonym: "RNase PH activity" EXACT [EC:2.7.7.56]
synonym: "tRNA:phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.56]
xref: EC:2.7.7.56
xref: MetaCyc:TRNA-NUCLEOTIDYLTRANSFERASE-RXN
is_a: GO:0016779 ! nucleotidyltransferase activity

[Term]
id: GO:0009023
name: obsolete tRNA sulfurtransferase
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: L-cysteine + activated-tRNA = L-serine + tRNA containing a thionucleotide." [EC:2.8.1.4, GOC:go_curators]
synonym: "tRNA sulfurtransferase" EXACT []
synonym: "tRNA sulphurtransferase activity" EXACT []
is_obsolete: true
replaced_by: GO:0034227
consider: GO:0016783

[Term]
id: GO:0009024
name: tagatose-6-phosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-tagatose 6-phosphate = ADP + D-tagatose 1,6-bisphosphate." [EC:2.7.1.144]
subset: gosubset_prok
synonym: "ATP:D-tagatose-6-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.144]
synonym: "phosphotagatokinase activity" EXACT [EC:2.7.1.144]
xref: EC:2.7.1.144
xref: MetaCyc:TAGAKIN-RXN
xref: RHEA:12423
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0009025
name: tagatose-bisphosphate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-tagatose 1,6-diphosphate = D-glyceraldehyde 3-phosphate + glycerone phosphate." [EC:4.1.2.40, RHEA:22951]
subset: gosubset_prok
synonym: "AgaY" RELATED []
synonym: "AgaZ" RELATED []
synonym: "D-tagatose-1,6-bisphosphate aldolase activity" EXACT [EC:4.1.2.40]
synonym: "D-tagatose-1,6-bisphosphate D-glyceraldehyde 3-phosphate-lyase (glycerone-phosphate-forming)" EXACT [EC:4.1.2.40]
synonym: "D-tagatose-1,6-bisphosphate triosephosphate lyase activity" EXACT []
synonym: "KbaY" RELATED []
synonym: "tagatose 1,6-diphosphate aldolase activity" EXACT [EC:4.1.2.40]
synonym: "tagatose-1,6-bisphosphate aldolase 1" EXACT []
xref: EC:4.1.2.40
xref: KEGG:R01069
xref: MetaCyc:TAGAALDOL-RXN
xref: RHEA:22951
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0009026
name: tagaturonate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-altronate + NAD(+) = D-tagaturonate + H(+) + NADH." [EC:1.1.1.58, RHEA:17816]
subset: gosubset_prok
synonym: "altronate dehydrogenase activity" EXACT [EC:1.1.1.58]
synonym: "altronate oxidoreductase activity" EXACT [EC:1.1.1.58]
synonym: "altronic oxidoreductase activity" EXACT [EC:1.1.1.58]
synonym: "D-altronate:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.58]
synonym: "D-tagaturonate reductase activity" EXACT [EC:1.1.1.58]
synonym: "tagaturonate dehydrogenase activity" EXACT [EC:1.1.1.58]
synonym: "TagUAR" RELATED [EC:1.1.1.58]
xref: EC:1.1.1.58
xref: KEGG:R02555
xref: MetaCyc:ALTRO-OXIDOREDUCT-RXN
xref: RHEA:17816
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0009027
name: tartrate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: tartrate + NAD+ = oxaloglycolate + NADH + H+." [EC:1.1.1.93]
subset: gosubset_prok
synonym: "mesotartrate dehydrogenase activity" EXACT [EC:1.1.1.93]
synonym: "tartrate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.93]
xref: EC:1.1.1.93
xref: MetaCyc:TARTRATE-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0009028
name: tartronate-semialdehyde synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 glyoxylate + H(+) = 2-hydroxy-3-oxopropanoate + CO(2)." [EC:4.1.1.47, RHEA:10139]
subset: gosubset_prok
synonym: "glyoxalate carboligase activity" EXACT [EC:4.1.1.47]
synonym: "glyoxylate carbo-ligase activity" EXACT [EC:4.1.1.47]
synonym: "glyoxylate carboligase activity" EXACT [EC:4.1.1.47]
synonym: "glyoxylate carboxy-lyase (dimerizing)" EXACT [EC:4.1.1.47]
synonym: "glyoxylate carboxy-lyase (dimerizing; tartronate-semialdehyde-forming)" EXACT [EC:4.1.1.47]
synonym: "glyoxylic carbo-ligase activity" EXACT [EC:4.1.1.47]
synonym: "hydroxymalonic semialdehyde carboxylase activity" EXACT [EC:4.1.1.47]
synonym: "tartronate semialdehyde carboxylase activity" EXACT [EC:4.1.1.47]
synonym: "tartronic semialdehyde carboxylase activity" EXACT [EC:4.1.1.47]
xref: EC:4.1.1.47
xref: KEGG:R00013
xref: MetaCyc:GLYOCARBOLIG-RXN
xref: RHEA:10139
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0009029
name: tetraacyldisaccharide 4'-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-(1->6)-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate + ATP = ADP + 2 H(+) + lipid IV(a)." [EC:2.7.1.130, RHEA:20703]
subset: gosubset_prok
synonym: "ATP:2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-beta-D-1,6-glucosaminyl-beta-phosphate 4'-O-phosphotransferase activity" EXACT [EC:2.7.1.130]
synonym: "lipid-A 4'-kinase activity" RELATED [EC:2.7.1.130]
xref: EC:2.7.1.130
xref: KEGG:R04657
xref: MetaCyc:TETRAACYLDISACC4KIN-RXN
xref: RHEA:20703
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0009030
name: thiamine-phosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + thiamine phosphate = ADP + H(+) + thiamine diphosphate." [EC:2.7.4.16, RHEA:15916]
subset: gosubset_prok
synonym: "ATP:thiamine-phosphate phosphotransferase activity" EXACT [EC:2.7.4.16]
synonym: "thiamin monophosphatase activity" EXACT [EC:2.7.4.16]
synonym: "thiamin monophosphokinase activity" EXACT [EC:2.7.4.16]
synonym: "thiamin phosphate kinase activity" EXACT [GOC:curators]
synonym: "thiamin-monophosphate kinase activity" EXACT [EC:2.7.4.16]
synonym: "thiamin-phosphate kinase activity" EXACT []
synonym: "thiamine-monophosphate kinase activity" EXACT [EC:2.7.4.16]
xref: EC:2.7.4.16
xref: KEGG:R00617
xref: MetaCyc:THI-P-KIN-RXN
xref: RHEA:15916
is_a: GO:0016301 ! kinase activity
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor

[Term]
id: GO:0009032
name: thymidine phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: thymidine + phosphate = thymine + 2-deoxy-D-ribose 1-phosphate." [EC:2.4.2.4]
subset: gosubset_prok
synonym: "animal growth regulators, blood platelet-derived endothelial cell growth factors" RELATED [EC:2.4.2.4]
synonym: "blood platelet-derived endothelial cell growth factor" RELATED [EC:2.4.2.4]
synonym: "deoxythymidine phosphorylase activity" EXACT [EC:2.4.2.4]
synonym: "gliostatins" RELATED [EC:2.4.2.4]
synonym: "pyrimidine deoxynucleoside phosphorylase activity" EXACT [EC:2.4.2.4]
synonym: "pyrimidine phosphorylase activity" BROAD [EC:2.4.2.4]
synonym: "thymidine-orthophosphate deoxyribosyltransferase activity" EXACT [EC:2.4.2.4]
synonym: "thymidine:phosphate deoxy-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.4]
synonym: "thymidine:phosphate deoxy-D-ribosyltransferase activity" EXACT [EC:2.4.2.4]
xref: EC:2.4.2.4
xref: MetaCyc:THYM-PHOSPH-RXN
xref: RHEA:16040
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0009033
name: trimethylamine-N-oxide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADH + H+ + trimethylamine-N-oxide = NAD+ + trimethylamine + H2O." [EC:1.6.6.9]
subset: gosubset_prok
synonym: "NADH:trimethylamine-N-oxide oxidoreductase" EXACT [EC:1.6.6.9]
synonym: "trimethylamine N-oxide reductase" EXACT [EC:1.6.6.9]
synonym: "trimethylamine oxidase activity" EXACT [EC:1.6.6.9]
synonym: "trimethylamine oxide reductase" EXACT [EC:1.6.6.9]
xref: EC:1.6.6.9
xref: MetaCyc:TMAOREDUCT-RXN
xref: RHEA:22027
is_a: GO:0016657 ! oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor

[Term]
id: GO:0009034
name: tryptophanase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tryptophan + H(2)O = indole + NH(4)(+) + pyruvate." [EC:4.1.99.1, RHEA:19556]
comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step.
subset: gosubset_prok
synonym: "L-tryptophan indole-lyase (deaminating) activity" EXACT [EC:4.1.99.1]
synonym: "L-tryptophan indole-lyase (deaminating; pyruvate forming) activity" EXACT [EC:4.1.99.1]
synonym: "L-tryptophan indole-lyase activity" EXACT [EC:4.1.99.1]
synonym: "L-tryptophanase activity" EXACT [EC:4.1.99.1]
synonym: "TNase activity" EXACT [EC:4.1.99.1]
synonym: "tryptophan catabolic process, using tryptophanase" RELATED [EC:4.1.99.1]
synonym: "tryptophan catabolism, using tryptophanase" RELATED [EC:4.1.99.1]
xref: EC:4.1.99.1
xref: KEGG:R00673
xref: MetaCyc:TRYPDEG-PWY
xref: MetaCyc:TRYPTOPHAN-RXN
xref: RHEA:19556
xref: UniPathway:UPA00332
is_a: GO:0016830 ! carbon-carbon lyase activity
relationship: part_of GO:0006569 ! tryptophan catabolic process

[Term]
id: GO:0009035
name: Type I site-specific deoxyribonuclease activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5' or 3' protrusions; ATP is simultaneously hydrolyzed. Cleavage is dependent on the presence in the DNA of a specific recognition site. Cleavage may occur hundreds or thousands of base pairs away from the recognition site due to translocation of DNA." [EC:3.1.21.3, PMID:15788748]
subset: gosubset_prok
synonym: "adenosine triphosphate-dependent deoxyribonuclease activity" EXACT [EC:3.1.21.3]
synonym: "ATP-dependent DNase activity" EXACT [EC:3.1.21.3]
synonym: "deoxyribonuclease (adenosine triphosphate-hydrolyzing)" EXACT [EC:3.1.21.3]
synonym: "deoxyribonuclease (ATP- and S-adenosyl-L-methionine-dependent)" EXACT [EC:3.1.21.3]
synonym: "Type I restriction enzyme activity" EXACT []
synonym: "type I site-specific deoxyribonuclease activity" EXACT [EC:3.1.21.3]
xref: EC:3.1.21.3
xref: MetaCyc:3.1.21.3-RXN
is_a: GO:0015666 ! restriction endodeoxyribonuclease activity
is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0009036
name: Type II site-specific deoxyribonuclease activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates and 3' hydroxyls. Cleavage is dependent on the presence in the DNA of a specific recognition site; cleavage occurs at or very near this recognition site." [EC:3.1.21.4, PMID:12654995]
subset: gosubset_prok
synonym: "Type II restriction enzyme activity" EXACT []
xref: EC:3.1.21.4
xref: MetaCyc:3.1.21.4-RXN
is_a: GO:0015666 ! restriction endodeoxyribonuclease activity
is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0009037
name: tyrosine-based site-specific recombinase activity
namespace: molecular_function
def: "Catalysis of the formation of new phosphodiester bonds between a pair of short, unique DNA target sequences; occurs through a phosphotyrosyl intermediate in which the target sequence is first cleaved by the nucleophilic attack by a tyrosine in the active site." [GOC:elh, PMID:11090626]
subset: gosubset_prok
synonym: "site-specific tyrosine recombinase activity" EXACT []
synonym: "tyrosine recombinase" BROAD []
is_a: GO:0008907 ! integrase activity
is_a: GO:0009009 ! site-specific recombinase activity

[Term]
id: GO:0009038
name: undecaprenol kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + undecaprenol = ADP + undecaprenyl phosphate." [EC:2.7.1.66, RHEA:23755]
subset: gosubset_prok
synonym: "ATP:undecaprenol phosphotransferase activity" EXACT [EC:2.7.1.66]
synonym: "C55-isoprenoid alcohol kinase activity" EXACT [EC:2.7.1.66]
synonym: "C55-isoprenoid alcohol phosphokinase activity" EXACT [EC:2.7.1.66]
synonym: "C55-isoprenyl alcohol phosphokinase activity" EXACT [EC:2.7.1.66]
synonym: "isoprenoid alcohol kinase (phosphorylating)" BROAD [EC:2.7.1.66]
synonym: "isoprenoid alcohol kinase activity" BROAD [EC:2.7.1.66]
synonym: "isoprenoid alcohol phosphokinase activity" BROAD [EC:2.7.1.66]
synonym: "isoprenoid-alcohol kinase activity" BROAD [EC:2.7.1.66]
synonym: "polyisoprenol kinase activity" BROAD [EC:2.7.1.66]
xref: EC:2.7.1.66
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0009039
name: urease activity
namespace: molecular_function
def: "Catalysis of the reaction: urea + H2O = CO2 + 2 NH3." [EC:3.5.1.5]
subset: gosubset_prok
synonym: "urea amidohydrolase activity" EXACT [EC:3.5.1.5]
xref: EC:3.5.1.5
xref: MetaCyc:UREASE-RXN
xref: RHEA:25346
xref: UM-BBD_reactionID:r0120
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0009040
name: ureidoglycolate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-ureidoglycolate + NAD(P)+ = oxalureate + NAD(P)H + H+." [EC:1.1.1.154, PMID:23284870]
subset: gosubset_prok
synonym: "(S)-ureidoglycolate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.154]
xref: EC:1.1.1.154
xref: MetaCyc:R165-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0009041
name: uridylate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + (d)UMP = ADP + (d)UDP." [GOC:go_curators]
subset: gosubset_prok
xref: EC:2.7.4.-
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor
is_a: GO:0019201 ! nucleotide kinase activity

[Term]
id: GO:0009042
name: valine-pyruvate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-valine + pyruvate = 3-methyl-2-oxobutanoate + L-alanine." [EC:2.6.1.66, RHEA:22915]
subset: gosubset_prok
synonym: "alanine--valine transaminase activity" EXACT [EC:2.6.1.66]
synonym: "alanine-oxoisovalerate aminotransferase activity" EXACT [EC:2.6.1.66]
synonym: "L-valine:pyruvate aminotransferase activity" EXACT [EC:2.6.1.66]
synonym: "transaminase C activity" NARROW [EC:2.6.1.66]
synonym: "valine--pyruvate aminotransferase activity" EXACT [EC:2.6.1.66]
synonym: "valine-pyruvate aminotransferase activity" EXACT []
xref: EC:2.6.1.66
xref: KEGG:R01215
xref: MetaCyc:VALINE-PYRUVATE-AMINOTRANSFER-RXN
xref: RHEA:22915
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0009044
name: xylan 1,4-beta-xylosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1->4)-beta-D-xylans so as to remove successive D-xylose residues from the non-reducing termini." [EC:3.2.1.37]
subset: gosubset_prok
synonym: "1,4-beta-D-xylan xylohydrolase activity" EXACT [EC:3.2.1.37]
synonym: "beta-D-xylopyranosidase activity" EXACT [EC:3.2.1.37]
synonym: "beta-xylosidase activity" EXACT [EC:3.2.1.37]
synonym: "exo-1,4-beta-D-xylosidase activity" EXACT [EC:3.2.1.37]
synonym: "exo-1,4-beta-xylosidase activity" EXACT [EC:3.2.1.37]
synonym: "exo-1,4-xylosidase activity" EXACT [EC:3.2.1.37]
synonym: "xylobiase activity" EXACT [EC:3.2.1.37]
xref: EC:3.2.1.37
xref: MetaCyc:3.2.1.37-RXN
is_a: GO:0097599 ! xylanase activity

[Term]
id: GO:0009045
name: xylose isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-xylose = D-xylulose." [EC:5.3.1.5]
subset: gosubset_prok
synonym: "D-xylose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.5]
synonym: "D-xylose isomerase activity" EXACT [EC:5.3.1.5]
synonym: "D-xylose ketoisomerase activity" EXACT [EC:5.3.1.5]
synonym: "D-xylose ketol-isomerase activity" EXACT [EC:5.3.1.5]
xref: EC:5.3.1.5
xref: MetaCyc:XYLISOM-RXN
xref: RHEA:22819
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0009046
name: zinc D-Ala-D-Ala carboxypeptidase activity
namespace: molecular_function
def: "Catalysis of the cleavage of the D-alanyl-D-alanine bond in (Ac)2-L-lysyl-D-alanyl-D-alanine." [EC:3.4.17.14]
synonym: "D-alanyl-D-alanine hydrolase activity" EXACT [EC:3.4.17.14]
synonym: "D-alanyl-D-alanine-cleaving carboxypeptidase activity" EXACT [EC:3.4.17.14]
synonym: "DD-carboxypeptidase" BROAD [EC:3.4.17.14]
synonym: "DD-carboxypeptidase-transpeptidase activity" EXACT [EC:3.4.17.14]
synonym: "G enzyme" RELATED [EC:3.4.17.14]
synonym: "Zn(2+) G peptidase activity" RELATED [EC:3.4.17.14]
synonym: "Zn2+ G peptidase activity" EXACT [EC:3.4.17.14]
xref: EC:3.4.17.14
xref: MetaCyc:3.4.17.14-RXN
is_a: GO:0004181 ! metallocarboxypeptidase activity

[Term]
id: GO:0009047
name: dosage compensation by hyperactivation of X chromosome
namespace: biological_process
def: "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global hyperactivation of all, or most of, the genes on the X-chromosome in the heterogametic sex, leading to a two-fold increase in gene expression from this chromosome. An example of this is found in Drosophila melanogaster." [GOC:jl, ISBN:0140512888, PMID:11498577]
is_a: GO:0007549 ! dosage compensation

[Term]
id: GO:0009048
name: dosage compensation by inactivation of X chromosome
namespace: biological_process
def: "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex." [GOC:jl, GOC:pr, ISBN:0140512888, PMID:11498577]
synonym: "Barr body formation" RELATED []
synonym: "chromosome inactivation" BROAD []
synonym: "X chromosome inactivation" EXACT []
xref: Wikipedia:X-inactivation
is_a: GO:0007549 ! dosage compensation

[Term]
id: GO:0009049
name: obsolete aspartic-type signal peptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of a signal peptide from a protein precursor by an aspartic endopeptidase mechanism." [GOC:mah]
comment: This term was made obsolete because 'signal peptide' is difficult to define unambiguously, and because the term refers to gene products.
subset: gosubset_prok
synonym: "aspartic-type signal peptidase activity" EXACT []
xref: EC:3.4.23.-
is_obsolete: true
replaced_by: GO:0004190

[Term]
id: GO:0009050
name: glycopeptide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycopeptides, any compound in which carbohydrate is covalently attached to an oligopeptide composed of residues of L and/or D-amino acids. The term usually denotes a product of proteolytic degradation of a glycoprotein but includes glycated peptide." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "glycopeptide breakdown" EXACT []
synonym: "glycopeptide catabolism" EXACT []
synonym: "glycopeptide degradation" EXACT []
is_a: GO:0043171 ! peptide catabolic process
is_a: GO:1901136 ! carbohydrate derivative catabolic process

[Term]
id: GO:0009051
name: pentose-phosphate shunt, oxidative branch
namespace: biological_process
def: "The branch of the pentose-phosphate shunt which involves the oxidation of glucose 6-P and produces ribulose 5-P, reduced NADP+ and carbon dioxide (CO2)." [ISBN:0198506732, MetaCyc:OXIDATIVEPENT-PWY]
subset: gosubset_prok
synonym: "oxidative branch, pentose pathway" EXACT []
synonym: "oxidative pentose phosphate pathway" EXACT []
synonym: "pentose phosphate pathway, oxidative branch" EXACT []
synonym: "pentose phosphate shunt, oxidative branch" EXACT []
synonym: "pentose-phosphate pathway, oxidative branch" EXACT []
xref: MetaCyc:OXIDATIVEPENT-PWY
is_a: GO:0006739 ! NADP metabolic process
is_a: GO:0051156 ! glucose 6-phosphate metabolic process
relationship: has_part GO:0004341 ! gluconolactonase activity
relationship: has_part GO:0006740 ! NADPH regeneration
relationship: part_of GO:0006098 ! pentose-phosphate shunt

[Term]
id: GO:0009052
name: pentose-phosphate shunt, non-oxidative branch
namespace: biological_process
def: "The branch of the pentose-phosphate shunt which does not involve oxidation reactions. It comprises a series of sugar phosphate interconversions, starting with ribulose 5-P and producing fructose 6-P and glyceraldehyde 3-P." [ISBN:0198506732, MetaCyc:NONOXIPENT-PWY]
subset: gosubset_prok
synonym: "pentose phosphate pathway, non-oxidative branch" EXACT []
synonym: "pentose phosphate shunt, non-oxidative branch" EXACT []
synonym: "pentose-phosphate pathway, non-oxidative branch" EXACT []
xref: MetaCyc:NONOXIPENT-PWY
xref: MetaCyc:P21-PWY
is_a: GO:0019682 ! glyceraldehyde-3-phosphate metabolic process
is_a: GO:0019693 ! ribose phosphate metabolic process
relationship: has_part GO:0004750 ! ribulose-phosphate 3-epimerase activity
relationship: has_part GO:0004751 ! ribose-5-phosphate isomerase activity
relationship: has_part GO:0004801 ! sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity
relationship: has_part GO:0004802 ! transketolase activity
relationship: part_of GO:0006098 ! pentose-phosphate shunt

[Term]
id: GO:0009055
name: electron carrier activity
namespace: molecular_function
alt_id: GO:0009053
alt_id: GO:0009054
def: "Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
synonym: "2Fe-2S electron transfer carrier" NARROW []
synonym: "3Fe-4S/4Fe-4S electron transfer carrier" NARROW []
synonym: "adrenodoxin-type ferredoxin" NARROW []
synonym: "amicyanin" NARROW []
synonym: "azurin" NARROW []
synonym: "bacterial-type ferredoxin" NARROW []
synonym: "chloroplast-type ferredoxin" NARROW []
synonym: "copper electron carrier" NARROW []
synonym: "dicluster bacterial-type ferredoxin" NARROW []
synonym: "electron acceptor activity" NARROW []
synonym: "electron carrier, chlorophyll electron transport system" RELATED []
synonym: "electron donor activity" NARROW []
synonym: "electron transfer flavoprotein" NARROW []
synonym: "electron transfer flavoprotein, group I" NARROW []
synonym: "electron transfer flavoprotein, group II" NARROW []
synonym: "electron transporter activity" EXACT []
synonym: "high-potential iron-sulfur carrier" NARROW []
synonym: "iron-sulfur electron transfer carrier" NARROW []
synonym: "monocluster bacterial-type ferredoxin" NARROW []
synonym: "mononuclear iron electron carrier" NARROW []
synonym: "polyferredoxin" NARROW []
synonym: "redox-active disulfide bond electron carrier" NARROW []
synonym: "rubredoxin" NARROW []
synonym: "small blue copper electron carrier" NARROW []
synonym: "thioredoxin-like 2Fe-2S ferredoxin" NARROW []
xref: Reactome:REACT_100606 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Caenorhabditis elegans"
xref: Reactome:REACT_107372 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Xenopus tropicalis"
xref: Reactome:REACT_107740 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Mus musculus"
xref: Reactome:REACT_107845 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Rattus norvegicus"
xref: Reactome:REACT_108215 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Saccharomyces cerevisiae"
xref: Reactome:REACT_109222 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Danio rerio"
xref: Reactome:REACT_28440 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Escherichia coli"
xref: Reactome:REACT_29712 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Bos taurus"
xref: Reactome:REACT_31774 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Dictyostelium discoideum"
xref: Reactome:REACT_6154 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Homo sapiens"
xref: Reactome:REACT_78399 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Sus scrofa"
xref: Reactome:REACT_81671 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Arabidopsis thaliana"
xref: Reactome:REACT_89868 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Taeniopygia guttata"
xref: Reactome:REACT_94498 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Drosophila melanogaster"
xref: Reactome:REACT_98413 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Canis familiaris"
xref: Reactome:REACT_98930 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Schizosaccharomyces pombe"
xref: Reactome:REACT_99683 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Mycobacterium tuberculosis"
xref: Reactome:REACT_99848 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Oryza sativa"
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0009056
name: catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_plant
subset: gosubset_prok
synonym: "breakdown" EXACT []
synonym: "catabolism" EXACT []
synonym: "degradation" EXACT []
xref: Wikipedia:Catabolism
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0009057
name: macromolecule catabolic process
namespace: biological_process
alt_id: GO:0043285
def: "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [CHEBI:33694, GOC:mah]
subset: gosubset_prok
synonym: "biopolymer catabolic process" EXACT [GOC:mtg_chebi_dec09]
synonym: "macromolecule breakdown" EXACT []
synonym: "macromolecule catabolism" EXACT []
synonym: "macromolecule degradation" EXACT []
is_a: GO:0043170 ! macromolecule metabolic process
is_a: GO:1901575 ! organic substance catabolic process

[Term]
id: GO:0009058
name: biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_plant
subset: gosubset_prok
synonym: "anabolism" EXACT []
synonym: "biosynthesis" EXACT []
synonym: "formation" EXACT []
synonym: "synthesis" EXACT []
xref: Wikipedia:Anabolism
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0009059
name: macromolecule biosynthetic process
namespace: biological_process
alt_id: GO:0043284
def: "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [CHEBI:33694, GOC:mah]
subset: gosubset_prok
synonym: "biopolymer biosynthetic process" EXACT [GOC:mtg_chebi_dec09]
synonym: "macromolecule anabolism" EXACT []
synonym: "macromolecule biosynthesis" EXACT []
synonym: "macromolecule formation" EXACT []
synonym: "macromolecule synthesis" EXACT []
is_a: GO:0043170 ! macromolecule metabolic process
is_a: GO:1901576 ! organic substance biosynthetic process

[Term]
id: GO:0009060
name: aerobic respiration
namespace: biological_process
def: "The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor." [GOC:das, GOC:jl, ISBN:0140513590]
subset: gosubset_prok
xref: MetaCyc:PWY-3781
xref: Wikipedia:Cellular_respiration#Aerobic_respiration
is_a: GO:0045333 ! cellular respiration

[Term]
id: GO:0009061
name: anaerobic respiration
namespace: biological_process
def: "The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which uses compounds other than oxygen (e.g. nitrate, sulfate) as the terminal electron acceptor." [GOC:das, GOC:jl, ISBN:0140513590]
subset: gosubset_prok
xref: MetaCyc:ANARESP1-PWY
xref: Wikipedia:Anaerobic_respiration
xref: Wikipedia:Cellular_respiration#Anaerobic_respiration
is_a: GO:0045333 ! cellular respiration

[Term]
id: GO:0009062
name: fatty acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:go_curators]
subset: gosubset_prok
synonym: "fatty acid breakdown" EXACT []
synonym: "fatty acid catabolism" EXACT []
synonym: "fatty acid degradation" EXACT []
xref: Wikipedia:Fatty_acid_degradation
is_a: GO:0006631 ! fatty acid metabolic process
is_a: GO:0044242 ! cellular lipid catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0009063
name: cellular amino acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents." [GOC:ai]
subset: gosubset_prok
synonym: "amino acid catabolic process" EXACT [GOC:curators]
synonym: "cellular amino acid breakdown" EXACT []
synonym: "cellular amino acid catabolism" EXACT []
synonym: "cellular amino acid degradation" EXACT []
is_a: GO:0006520 ! cellular amino acid metabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process

[Term]
id: GO:0009064
name: glutamine family amino acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:ai]
subset: gosubset_prok
synonym: "glutamine family amino acid metabolism" EXACT []
is_a: GO:1901605 ! alpha-amino acid metabolic process

[Term]
id: GO:0009065
name: glutamine family amino acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:ai]
subset: gosubset_prok
synonym: "glutamine family amino acid breakdown" EXACT []
synonym: "glutamine family amino acid catabolism" EXACT []
synonym: "glutamine family amino acid degradation" EXACT []
is_a: GO:0009064 ! glutamine family amino acid metabolic process
is_a: GO:1901606 ! alpha-amino acid catabolic process

[Term]
id: GO:0009066
name: aspartate family amino acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine." [GOC:ai]
subset: gosubset_prok
synonym: "aspartate family amino acid metabolism" EXACT []
is_a: GO:1901605 ! alpha-amino acid metabolic process

[Term]
id: GO:0009067
name: aspartate family amino acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine." [GOC:ai]
subset: gosubset_prok
synonym: "aspartate family amino acid anabolism" EXACT []
synonym: "aspartate family amino acid biosynthesis" EXACT []
synonym: "aspartate family amino acid formation" EXACT []
synonym: "aspartate family amino acid synthesis" EXACT []
is_a: GO:0009066 ! aspartate family amino acid metabolic process
is_a: GO:1901607 ! alpha-amino acid biosynthetic process

[Term]
id: GO:0009068
name: aspartate family amino acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine." [GOC:ai]
subset: gosubset_prok
synonym: "aspartate family amino acid breakdown" EXACT []
synonym: "aspartate family amino acid catabolism" EXACT []
synonym: "aspartate family amino acid degradation" EXACT []
is_a: GO:0009066 ! aspartate family amino acid metabolic process
is_a: GO:1901606 ! alpha-amino acid catabolic process

[Term]
id: GO:0009069
name: serine family amino acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine." [GOC:ai]
subset: gosubset_prok
synonym: "serine family amino acid metabolism" EXACT []
is_a: GO:1901605 ! alpha-amino acid metabolic process

[Term]
id: GO:0009070
name: serine family amino acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine." [GOC:ai]
subset: gosubset_prok
synonym: "serine family amino acid anabolism" EXACT []
synonym: "serine family amino acid biosynthesis" EXACT []
synonym: "serine family amino acid formation" EXACT []
synonym: "serine family amino acid synthesis" EXACT []
is_a: GO:0009069 ! serine family amino acid metabolic process
is_a: GO:1901607 ! alpha-amino acid biosynthetic process

[Term]
id: GO:0009071
name: serine family amino acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine." [GOC:ai]
subset: gosubset_prok
synonym: "serine family amino acid breakdown" EXACT []
synonym: "serine family amino acid catabolism" EXACT []
synonym: "serine family amino acid degradation" EXACT []
is_a: GO:0009069 ! serine family amino acid metabolic process
is_a: GO:1901606 ! alpha-amino acid catabolic process

[Term]
id: GO:0009072
name: aromatic amino acid family metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators]
subset: gosubset_prok
synonym: "aromatic amino acid family metabolism" EXACT []
is_a: GO:0006520 ! cellular amino acid metabolic process
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process

[Term]
id: GO:0009073
name: aromatic amino acid family biosynthetic process
namespace: biological_process
alt_id: GO:0016089
def: "The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators]
subset: gosubset_prok
synonym: "aromatic amino acid family anabolism" EXACT []
synonym: "aromatic amino acid family biosynthesis" EXACT []
synonym: "aromatic amino acid family biosynthetic process, shikimate pathway" RELATED []
synonym: "aromatic amino acid family formation" EXACT []
synonym: "aromatic amino acid family synthesis" EXACT []
xref: MetaCyc:COMPLETE-ARO-PWY
is_a: GO:0008652 ! cellular amino acid biosynthetic process
is_a: GO:0009072 ! aromatic amino acid family metabolic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process

[Term]
id: GO:0009074
name: aromatic amino acid family catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators]
subset: gosubset_prok
synonym: "aromatic amino acid family breakdown" EXACT []
synonym: "aromatic amino acid family catabolism" EXACT []
synonym: "aromatic amino acid family degradation" EXACT []
is_a: GO:0009063 ! cellular amino acid catabolic process
is_a: GO:0009072 ! aromatic amino acid family metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process

[Term]
id: GO:0009075
name: obsolete histidine family amino acid metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving amino acids of the histidine family." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term, as histidine would be the only member of this family.
subset: gosubset_prok
synonym: "histidine family amino acid metabolic process" EXACT []
synonym: "histidine family amino acid metabolism" EXACT []
is_obsolete: true
replaced_by: GO:0006547

[Term]
id: GO:0009076
name: obsolete histidine family amino acid biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of amino acids of the histidine family." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term, as histidine would be the only member of this family.
subset: gosubset_prok
synonym: "histidine family amino acid anabolism" EXACT []
synonym: "histidine family amino acid biosynthesis" EXACT []
synonym: "histidine family amino acid biosynthetic process" EXACT []
synonym: "histidine family amino acid formation" EXACT []
synonym: "histidine family amino acid synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0000105

[Term]
id: GO:0009077
name: obsolete histidine family amino acid catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of amino acids of the histidine family." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term, as histidine would be the only member of this family.
subset: gosubset_prok
synonym: "histidine family amino acid breakdown" EXACT []
synonym: "histidine family amino acid catabolic process" EXACT []
synonym: "histidine family amino acid catabolism" EXACT []
synonym: "histidine family amino acid degradation" EXACT []
is_obsolete: true
replaced_by: GO:0006548

[Term]
id: GO:0009078
name: pyruvate family amino acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any amino acid that requires pyruvate for its synthesis, e.g. alanine." [GOC:jl]
subset: gosubset_prok
synonym: "pyruvate family amino acid metabolism" EXACT []
is_a: GO:1901605 ! alpha-amino acid metabolic process

[Term]
id: GO:0009079
name: pyruvate family amino acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any amino acid that requires pyruvate for its synthesis, e.g. alanine." [GOC:jl]
subset: gosubset_prok
synonym: "pyruvate family amino acid anabolism" EXACT []
synonym: "pyruvate family amino acid biosynthesis" EXACT []
synonym: "pyruvate family amino acid formation" EXACT []
synonym: "pyruvate family amino acid synthesis" EXACT []
is_a: GO:0009078 ! pyruvate family amino acid metabolic process
is_a: GO:1901607 ! alpha-amino acid biosynthetic process

[Term]
id: GO:0009080
name: pyruvate family amino acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any amino acid that requires pyruvate for its synthesis, e.g. alanine." [GOC:jl]
subset: gosubset_prok
synonym: "pyruvate family amino acid breakdown" EXACT []
synonym: "pyruvate family amino acid catabolism" EXACT []
synonym: "pyruvate family amino acid degradation" EXACT []
is_a: GO:0009078 ! pyruvate family amino acid metabolic process
is_a: GO:1901606 ! alpha-amino acid catabolic process

[Term]
id: GO:0009081
name: branched-chain amino acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine." [CHEBI:22918, GOC:ai]
subset: gosubset_prok
synonym: "branched chain family amino acid metabolism" EXACT [GOC:ai]
is_a: GO:0006520 ! cellular amino acid metabolic process

[Term]
id: GO:0009082
name: branched-chain amino acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine." [CHEBI:22918, GOC:ai]
subset: gosubset_prok
synonym: "branched chain family amino acid anabolism" EXACT []
synonym: "branched chain family amino acid biosynthesis" EXACT []
synonym: "branched chain family amino acid biosynthetic process" EXACT [GOC:ai]
synonym: "branched chain family amino acid formation" EXACT []
synonym: "branched chain family amino acid synthesis" EXACT []
is_a: GO:0008652 ! cellular amino acid biosynthetic process
is_a: GO:0009081 ! branched-chain amino acid metabolic process

[Term]
id: GO:0009083
name: branched-chain amino acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine." [GOC:ai]
subset: gosubset_prok
synonym: "branched chain family amino acid breakdown" EXACT []
synonym: "branched chain family amino acid catabolic process" EXACT [GOC:ai]
synonym: "branched chain family amino acid catabolism" EXACT []
synonym: "branched chain family amino acid degradation" EXACT []
xref: Reactome:REACT_101993 "Branched-chain amino acid catabolism, Mycobacterium tuberculosis"
xref: Reactome:REACT_104316 "Branched-chain amino acid catabolism, Saccharomyces cerevisiae"
xref: Reactome:REACT_105382 "Branched-chain amino acid catabolism, Rattus norvegicus"
xref: Reactome:REACT_197 "Branched-chain amino acid catabolism, Homo sapiens"
xref: Reactome:REACT_29688 "Branched-chain amino acid catabolism, Taeniopygia guttata"
xref: Reactome:REACT_32990 "Branched-chain amino acid catabolism, Mus musculus"
xref: Reactome:REACT_33721 "Branched-chain amino acid catabolism, Staphylococcus aureus N315"
xref: Reactome:REACT_33760 "Branched-chain amino acid catabolism, Schizosaccharomyces pombe"
xref: Reactome:REACT_82706 "Branched-chain amino acid catabolism, Oryza sativa"
xref: Reactome:REACT_84729 "Branched-chain amino acid catabolism, Xenopus tropicalis"
xref: Reactome:REACT_87106 "Branched-chain amino acid catabolism, Danio rerio"
xref: Reactome:REACT_87459 "Branched-chain amino acid catabolism, Caenorhabditis elegans"
xref: Reactome:REACT_89793 "Branched-chain amino acid catabolism, Arabidopsis thaliana"
xref: Reactome:REACT_90261 "Branched-chain amino acid catabolism, Canis familiaris"
xref: Reactome:REACT_90392 "Branched-chain amino acid catabolism, Dictyostelium discoideum"
xref: Reactome:REACT_92585 "Branched-chain amino acid catabolism, Plasmodium falciparum"
xref: Reactome:REACT_93183 "Branched-chain amino acid catabolism, Drosophila melanogaster"
xref: Reactome:REACT_95044 "Branched-chain amino acid catabolism, Bos taurus"
xref: Reactome:REACT_97477 "Branched-chain amino acid catabolism, Gallus gallus"
xref: Reactome:REACT_98686 "Branched-chain amino acid catabolism, Sus scrofa"
is_a: GO:0009063 ! cellular amino acid catabolic process
is_a: GO:0009081 ! branched-chain amino acid metabolic process

[Term]
id: GO:0009084
name: glutamine family amino acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:ai]
subset: gosubset_prok
synonym: "glutamine family amino acid anabolism" EXACT []
synonym: "glutamine family amino acid biosynthesis" EXACT []
synonym: "glutamine family amino acid formation" EXACT []
synonym: "glutamine family amino acid synthesis" EXACT []
is_a: GO:0009064 ! glutamine family amino acid metabolic process
is_a: GO:1901607 ! alpha-amino acid biosynthetic process

[Term]
id: GO:0009085
name: lysine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lysine, 2,6-diaminohexanoic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "lysine anabolism" EXACT []
synonym: "lysine biosynthesis" EXACT []
synonym: "lysine formation" EXACT []
synonym: "lysine synthesis" EXACT []
xref: MetaCyc:PWY-5097
is_a: GO:0006553 ! lysine metabolic process
is_a: GO:0009067 ! aspartate family amino acid biosynthetic process

[Term]
id: GO:0009086
name: methionine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "methionine anabolism" EXACT []
synonym: "methionine biosynthesis" EXACT []
synonym: "methionine formation" EXACT []
synonym: "methionine synthesis" EXACT []
is_a: GO:0000097 ! sulfur amino acid biosynthetic process
is_a: GO:0006555 ! methionine metabolic process
is_a: GO:0009067 ! aspartate family amino acid biosynthetic process

[Term]
id: GO:0009087
name: methionine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "methionine breakdown" EXACT []
synonym: "methionine catabolism" EXACT []
synonym: "methionine degradation" EXACT []
xref: UM-BBD_pathwayID:met
is_a: GO:0000098 ! sulfur amino acid catabolic process
is_a: GO:0006555 ! methionine metabolic process
is_a: GO:0009068 ! aspartate family amino acid catabolic process

[Term]
id: GO:0009088
name: threonine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "threonine anabolism" EXACT []
synonym: "threonine biosynthesis" EXACT []
synonym: "threonine formation" EXACT []
synonym: "threonine synthesis" EXACT []
xref: MetaCyc:HOMOSER-THRESYN-PWY
xref: MetaCyc:THRESYN-PWY
is_a: GO:0006566 ! threonine metabolic process
is_a: GO:0009067 ! aspartate family amino acid biosynthetic process

[Term]
id: GO:0009089
name: lysine biosynthetic process via diaminopimelate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate." [GOC:go_curators]
subset: gosubset_prok
synonym: "diaminopimelate pathway" EXACT []
synonym: "diaminopimelic acid pathway" EXACT []
synonym: "lysine anabolism via diaminopimelate" EXACT []
synonym: "lysine biosynthesis via diaminopimelic acid" EXACT []
synonym: "lysine biosynthetic process via diaminopimelic acid" EXACT []
synonym: "lysine formation via diaminopimelate" EXACT []
synonym: "lysine synthesis via diaminopimelate" EXACT []
is_a: GO:0009085 ! lysine biosynthetic process
is_a: GO:0046451 ! diaminopimelate metabolic process

[Term]
id: GO:0009090
name: homoserine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of homoserine, alpha-amino-gamma-hydroxybutyric acid." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "homoserine anabolism" EXACT []
synonym: "homoserine biosynthesis" EXACT []
synonym: "homoserine formation" EXACT []
synonym: "homoserine synthesis" EXACT []
xref: MetaCyc:HOMOSERSYN-PWY
is_a: GO:0009070 ! serine family amino acid biosynthetic process
is_a: GO:0009092 ! homoserine metabolic process

[Term]
id: GO:0009091
name: homoserine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of homoserine, alpha-amino-gamma-hydroxybutyric acid." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "homoserine breakdown" EXACT []
synonym: "homoserine catabolism" EXACT []
synonym: "homoserine degradation" EXACT []
xref: MetaCyc:HOMOCYSDEGR-PWY
is_a: GO:0009071 ! serine family amino acid catabolic process
is_a: GO:0009092 ! homoserine metabolic process

[Term]
id: GO:0009092
name: homoserine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving homoserine, alpha-amino-gamma-hydroxybutyric acid, an intermediate in the biosynthesis of cystathionine, threonine and methionine." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "homoserine metabolism" EXACT []
is_a: GO:0009069 ! serine family amino acid metabolic process

[Term]
id: GO:0009093
name: cysteine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cysteine, 2-amino-3-mercaptopropanoic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "cysteine breakdown" EXACT []
synonym: "cysteine catabolism" EXACT []
synonym: "cysteine degradation" EXACT []
xref: Wikipedia:Cysteine
is_a: GO:0000098 ! sulfur amino acid catabolic process
is_a: GO:0006534 ! cysteine metabolic process
is_a: GO:0009071 ! serine family amino acid catabolic process

[Term]
id: GO:0009094
name: L-phenylalanine biosynthetic process
namespace: biological_process
alt_id: GO:0019274
alt_id: GO:0019275
def: "The chemical reactions and pathways resulting in the formation of L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid." [CHEBI:17295, GOC:go_curators, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "L-phenylalanine anabolism" EXACT []
synonym: "L-phenylalanine biosynthesis" EXACT []
synonym: "L-phenylalanine formation" EXACT []
synonym: "L-phenylalanine synthesis" EXACT []
synonym: "phenylalanine biosynthesis" BROAD []
synonym: "phenylalanine biosynthetic process" BROAD []
synonym: "phenylalanine biosynthetic process, prephenate pathway" RELATED []
synonym: "phenylalanine biosynthetic process, shikimate pathway" RELATED []
is_a: GO:0006558 ! L-phenylalanine metabolic process
is_a: GO:0009095 ! aromatic amino acid family biosynthetic process, prephenate pathway
is_a: GO:1902223 ! erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process

[Term]
id: GO:0009095
name: aromatic amino acid family biosynthetic process, prephenate pathway
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phenylalanine and tyrosine from other compounds, including chorismate, via the intermediate prephenate." [GOC:mah, ISBN:0471331309]
subset: gosubset_prok
synonym: "aromatic amino acid family anabolism, prephenate pathway" EXACT []
synonym: "aromatic amino acid family biosynthetic process via prephenate" EXACT [GOC:pr]
synonym: "aromatic amino acid family biosynthetic process via prephenate(2-)" EXACT [GOC:pr]
synonym: "aromatic amino acid family formation, prephenate pathway" EXACT []
synonym: "aromatic amino acid family synthesis, prephenate pathway" EXACT []
is_a: GO:0009073 ! aromatic amino acid family biosynthetic process

[Term]
id: GO:0009097
name: isoleucine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid." [GOC:ai]
subset: gosubset_prok
synonym: "isoleucine anabolism" EXACT []
synonym: "isoleucine biosynthesis" EXACT []
synonym: "isoleucine formation" EXACT []
synonym: "isoleucine synthesis" EXACT []
xref: MetaCyc:ILEUSYN-PWY
is_a: GO:0006549 ! isoleucine metabolic process
is_a: GO:0009082 ! branched-chain amino acid biosynthetic process
is_a: GO:1901607 ! alpha-amino acid biosynthetic process

[Term]
id: GO:0009098
name: leucine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid." [GOC:ai]
subset: gosubset_prok
synonym: "leucine anabolism" EXACT []
synonym: "leucine biosynthesis" EXACT []
synonym: "leucine formation" EXACT []
synonym: "leucine synthesis" EXACT []
xref: MetaCyc:LEUSYN-PWY
is_a: GO:0006551 ! leucine metabolic process
is_a: GO:0009082 ! branched-chain amino acid biosynthetic process
is_a: GO:1901607 ! alpha-amino acid biosynthetic process

[Term]
id: GO:0009099
name: valine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of valine, 2-amino-3-methylbutanoic acid." [GOC:ai]
subset: gosubset_prok
synonym: "valine anabolism" EXACT []
synonym: "valine biosynthesis" EXACT []
synonym: "valine formation" EXACT []
synonym: "valine synthesis" EXACT []
xref: MetaCyc:VALSYN-PWY
is_a: GO:0006573 ! valine metabolic process
is_a: GO:0009082 ! branched-chain amino acid biosynthetic process
is_a: GO:1901607 ! alpha-amino acid biosynthetic process

[Term]
id: GO:0009100
name: glycoprotein metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "glycoprotein metabolism" EXACT []
is_a: GO:0019538 ! protein metabolic process
is_a: GO:0044260 ! cellular macromolecule metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:0009101
name: glycoprotein biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "glycoprotein anabolism" EXACT []
synonym: "glycoprotein biosynthesis" EXACT []
synonym: "glycoprotein formation" EXACT []
synonym: "glycoprotein synthesis" EXACT []
is_a: GO:0009100 ! glycoprotein metabolic process
is_a: GO:0034645 ! cellular macromolecule biosynthetic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process

[Term]
id: GO:0009102
name: biotin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid." [ISBN:0198506732]
subset: gosubset_prok
synonym: "biotin anabolism" EXACT []
synonym: "biotin biosynthesis" EXACT []
synonym: "biotin formation" EXACT []
synonym: "biotin synthesis" EXACT []
synonym: "vitamin B7 biosynthesis" EXACT []
synonym: "vitamin B7 biosynthetic process" EXACT []
synonym: "vitamin H biosynthesis" EXACT []
synonym: "vitamin H biosynthetic process" EXACT []
xref: MetaCyc:BIOTIN-SYNTHESIS-PWY
is_a: GO:0006768 ! biotin metabolic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0042364 ! water-soluble vitamin biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process

[Term]
id: GO:0009103
name: lipopolysaccharide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria." [GOC:ai, GOC:mr]
subset: gosubset_prok
synonym: "lipopolysaccharide anabolism" EXACT []
synonym: "lipopolysaccharide biosynthesis" EXACT []
synonym: "lipopolysaccharide formation" EXACT []
synonym: "lipopolysaccharide synthesis" EXACT []
synonym: "LPS biosynthetic process" EXACT []
is_a: GO:0008610 ! lipid biosynthetic process
is_a: GO:0008653 ! lipopolysaccharide metabolic process
is_a: GO:0033692 ! cellular polysaccharide biosynthetic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process

[Term]
id: GO:0009104
name: lipopolysaccharide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria." [GOC:ai]
subset: gosubset_prok
synonym: "lipopolysaccharide breakdown" EXACT []
synonym: "lipopolysaccharide catabolism" EXACT []
synonym: "lipopolysaccharide degradation" EXACT []
synonym: "LPS catabolic process" EXACT []
is_a: GO:0008653 ! lipopolysaccharide metabolic process
is_a: GO:0044242 ! cellular lipid catabolic process
is_a: GO:0044247 ! cellular polysaccharide catabolic process
is_a: GO:0044724 ! single-organism carbohydrate catabolic process
is_a: GO:1901136 ! carbohydrate derivative catabolic process

[Term]
id: GO:0009106
name: lipoate metabolic process
namespace: biological_process
alt_id: GO:0000273
def: "The chemical reactions and pathways involving lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid." [GOC:ai, ISBN:0198506732]
subset: gosubset_prok
synonym: "lipoate metabolism" EXACT []
synonym: "lipoic acid metabolic process" EXACT []
synonym: "lipoic acid metabolism" EXACT []
is_a: GO:0006631 ! fatty acid metabolic process
is_a: GO:0006732 ! coenzyme metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process

[Term]
id: GO:0009107
name: lipoate biosynthetic process
namespace: biological_process
alt_id: GO:0009105
def: "The chemical reactions and pathways resulting in the formation of lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid." [GOC:ai, ISBN:0198506732]
subset: gosubset_prok
synonym: "lipoate anabolism" EXACT []
synonym: "lipoate biosynthesis" EXACT []
synonym: "lipoate formation" EXACT []
synonym: "lipoate synthesis" EXACT []
synonym: "lipoic acid anabolism" EXACT []
synonym: "lipoic acid biosynthesis" EXACT []
synonym: "lipoic acid biosynthetic process" EXACT []
synonym: "lipoic acid formation" EXACT []
synonym: "lipoic acid synthesis" EXACT []
is_a: GO:0006633 ! fatty acid biosynthetic process
is_a: GO:0009106 ! lipoate metabolic process
is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process

[Term]
id: GO:0009108
name: coenzyme biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [GOC:ai]
subset: gosubset_prok
synonym: "coenzyme anabolism" EXACT []
synonym: "coenzyme and prosthetic group biosynthesis" BROAD []
synonym: "coenzyme and prosthetic group biosynthetic process" BROAD []
synonym: "coenzyme biosynthesis" EXACT []
synonym: "coenzyme formation" EXACT []
synonym: "coenzyme synthesis" EXACT []
xref: Reactome:REACT_102165 "Coenzyme A biosynthesis, Danio rerio"
xref: Reactome:REACT_104949 "Coenzyme A biosynthesis, Staphylococcus aureus N315"
xref: Reactome:REACT_107153 "Coenzyme A biosynthesis, Caenorhabditis elegans"
xref: Reactome:REACT_110132 "Coenzyme A biosynthesis, Escherichia coli"
xref: Reactome:REACT_11218 "Coenzyme A biosynthesis, Homo sapiens"
xref: Reactome:REACT_29910 "Coenzyme A biosynthesis, Xenopus tropicalis"
xref: Reactome:REACT_31159 "Coenzyme A biosynthesis, Mycobacterium tuberculosis"
xref: Reactome:REACT_31595 "Coenzyme A biosynthesis, Dictyostelium discoideum"
xref: Reactome:REACT_32424 "Coenzyme A biosynthesis, Bos taurus"
xref: Reactome:REACT_32705 "Coenzyme A biosynthesis, Saccharomyces cerevisiae"
xref: Reactome:REACT_79517 "Coenzyme A biosynthesis, Mus musculus"
xref: Reactome:REACT_84587 "Coenzyme A biosynthesis, Plasmodium falciparum"
xref: Reactome:REACT_87576 "Coenzyme A biosynthesis, Gallus gallus"
xref: Reactome:REACT_89074 "Coenzyme A biosynthesis, Arabidopsis thaliana"
xref: Reactome:REACT_90447 "Coenzyme A biosynthesis, Sus scrofa"
xref: Reactome:REACT_96160 "Coenzyme A biosynthesis, Canis familiaris"
xref: Reactome:REACT_96658 "Coenzyme A biosynthesis, Rattus norvegicus"
xref: Reactome:REACT_97175 "Coenzyme A biosynthesis, Schizosaccharomyces pombe"
xref: Reactome:REACT_98290 "Coenzyme A biosynthesis, Drosophila melanogaster"
xref: Reactome:REACT_98603 "Coenzyme A biosynthesis, Taeniopygia guttata"
xref: Reactome:REACT_99961 "Coenzyme A biosynthesis, Oryza sativa"
is_a: GO:0006732 ! coenzyme metabolic process
is_a: GO:0051188 ! cofactor biosynthetic process

[Term]
id: GO:0009109
name: coenzyme catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [GOC:ai]
subset: gosubset_prok
synonym: "coenzyme and prosthetic group catabolic process" BROAD []
synonym: "coenzyme and prosthetic group catabolism" BROAD []
synonym: "coenzyme breakdown" EXACT []
synonym: "coenzyme catabolism" EXACT []
synonym: "coenzyme degradation" EXACT []
is_a: GO:0006732 ! coenzyme metabolic process
is_a: GO:0051187 ! cofactor catabolic process

[Term]
id: GO:0009110
name: vitamin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "vitamin anabolism" EXACT []
synonym: "vitamin biosynthesis" EXACT []
synonym: "vitamin formation" EXACT []
synonym: "vitamin synthesis" EXACT []
is_a: GO:0006766 ! vitamin metabolic process
is_a: GO:0044249 ! cellular biosynthetic process
is_a: GO:0044283 ! small molecule biosynthetic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0009111
name: vitamin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]
subset: gosubset_prok
synonym: "vitamin breakdown" EXACT []
synonym: "vitamin catabolism" EXACT []
synonym: "vitamin degradation" EXACT []
is_a: GO:0006766 ! vitamin metabolic process
is_a: GO:0044248 ! cellular catabolic process
is_a: GO:0044282 ! small molecule catabolic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0009112
name: nucleobase metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a nucleobase, a nitrogenous base that is a constituent of a nucleic acid, e.g. the purines: adenine, guanine, hypoxanthine, xanthine and the pyrimidines: cytosine, uracil, thymine." [GOC:ma]
subset: gosubset_prok
synonym: "nucleobase metabolism" EXACT []
is_a: GO:0055086 ! nucleobase-containing small molecule metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process

[Term]
id: GO:0009113
name: purine nucleobase biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." [CHEBI:26386, GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "purine base anabolism" EXACT []
synonym: "purine base biosynthesis" EXACT []
synonym: "purine base biosynthetic process" EXACT [GOC:go_curators]
synonym: "purine base formation" EXACT []
synonym: "purine base synthesis" EXACT []
xref: MetaCyc:PWY-841
is_a: GO:0006144 ! purine nucleobase metabolic process
is_a: GO:0046112 ! nucleobase biosynthetic process
is_a: GO:0046148 ! pigment biosynthetic process
is_a: GO:0072522 ! purine-containing compound biosynthetic process

[Term]
id: GO:0009114
name: hypoxanthine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate." [GOC:go_curators]
subset: gosubset_prok
synonym: "hypoxanthine breakdown" EXACT []
synonym: "hypoxanthine catabolism" EXACT []
synonym: "hypoxanthine degradation" EXACT []
is_a: GO:0006145 ! purine nucleobase catabolic process
is_a: GO:0046100 ! hypoxanthine metabolic process

[Term]
id: GO:0009115
name: xanthine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids." [GOC:go_curators]
subset: gosubset_prok
synonym: "xanthine breakdown" EXACT []
synonym: "xanthine catabolism" EXACT []
synonym: "xanthine degradation" EXACT []
is_a: GO:0006145 ! purine nucleobase catabolic process
is_a: GO:0046110 ! xanthine metabolic process

[Term]
id: GO:0009116
name: nucleoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine)." [GOC:ma]
subset: goslim_pir
subset: gosubset_prok
synonym: "nucleoside metabolism" EXACT []
is_a: GO:0055086 ! nucleobase-containing small molecule metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process
is_a: GO:1901657 ! glycosyl compound metabolic process

[Term]
id: GO:0009117
name: nucleotide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates)." [GOC:ma]
subset: goslim_metagenomics
subset: goslim_pir
subset: gosubset_prok
synonym: "nucleotide metabolism" EXACT []
is_a: GO:0006753 ! nucleoside phosphate metabolic process

[Term]
id: GO:0009118
name: regulation of nucleoside metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleosides." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of nucleoside metabolism" EXACT []
is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009116 ! nucleoside metabolic process
relationship: regulates GO:0009116 ! nucleoside metabolic process

[Term]
id: GO:0009119
name: ribonucleoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule." [CHEBI:18254, GOC:jl]
subset: gosubset_prok
synonym: "ribonucleoside metabolism" EXACT []
is_a: GO:0009116 ! nucleoside metabolic process

[Term]
id: GO:0009120
name: deoxyribonucleoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:jl, ISBN:0140512713]
subset: gosubset_prok
synonym: "deoxyribonucleoside metabolism" EXACT []
is_a: GO:0009116 ! nucleoside metabolic process

[Term]
id: GO:0009123
name: nucleoside monophosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "nucleoside monophosphate metabolism" EXACT []
is_a: GO:0006753 ! nucleoside phosphate metabolic process

[Term]
id: GO:0009124
name: nucleoside monophosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "nucleoside monophosphate anabolism" EXACT []
synonym: "nucleoside monophosphate biosynthesis" EXACT []
synonym: "nucleoside monophosphate formation" EXACT []
synonym: "nucleoside monophosphate synthesis" EXACT []
is_a: GO:0009123 ! nucleoside monophosphate metabolic process
is_a: GO:1901293 ! nucleoside phosphate biosynthetic process

[Term]
id: GO:0009125
name: nucleoside monophosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "nucleoside monophosphate breakdown" EXACT []
synonym: "nucleoside monophosphate catabolism" EXACT []
synonym: "nucleoside monophosphate degradation" EXACT []
is_a: GO:0009123 ! nucleoside monophosphate metabolic process
is_a: GO:1901292 ! nucleoside phosphate catabolic process

[Term]
id: GO:0009126
name: purine nucleoside monophosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "purine nucleoside monophosphate metabolism" EXACT []
is_a: GO:0009123 ! nucleoside monophosphate metabolic process

[Term]
id: GO:0009127
name: purine nucleoside monophosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "purine nucleoside monophosphate anabolism" EXACT []
synonym: "purine nucleoside monophosphate biosynthesis" EXACT []
synonym: "purine nucleoside monophosphate formation" EXACT []
synonym: "purine nucleoside monophosphate synthesis" EXACT []
is_a: GO:0009124 ! nucleoside monophosphate biosynthetic process
is_a: GO:0009126 ! purine nucleoside monophosphate metabolic process

[Term]
id: GO:0009128
name: purine nucleoside monophosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "purine nucleoside monophosphate breakdown" EXACT []
synonym: "purine nucleoside monophosphate catabolism" EXACT []
synonym: "purine nucleoside monophosphate degradation" EXACT []
is_a: GO:0009125 ! nucleoside monophosphate catabolic process
is_a: GO:0009126 ! purine nucleoside monophosphate metabolic process

[Term]
id: GO:0009129
name: pyrimidine nucleoside monophosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pyrimidine nucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "pyrimidine nucleoside monophosphate metabolism" EXACT []
is_a: GO:0009123 ! nucleoside monophosphate metabolic process

[Term]
id: GO:0009130
name: pyrimidine nucleoside monophosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "pyrimidine nucleoside monophosphate anabolism" EXACT []
synonym: "pyrimidine nucleoside monophosphate biosynthesis" EXACT []
synonym: "pyrimidine nucleoside monophosphate formation" EXACT []
synonym: "pyrimidine nucleoside monophosphate synthesis" EXACT []
is_a: GO:0009124 ! nucleoside monophosphate biosynthetic process
is_a: GO:0009129 ! pyrimidine nucleoside monophosphate metabolic process

[Term]
id: GO:0009131
name: pyrimidine nucleoside monophosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "pyrimidine nucleoside monophosphate breakdown" EXACT []
synonym: "pyrimidine nucleoside monophosphate catabolism" EXACT []
synonym: "pyrimidine nucleoside monophosphate degradation" EXACT []
is_a: GO:0009125 ! nucleoside monophosphate catabolic process
is_a: GO:0009129 ! pyrimidine nucleoside monophosphate metabolic process

[Term]
id: GO:0009132
name: nucleoside diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "nucleoside diphosphate metabolism" EXACT []
is_a: GO:0006753 ! nucleoside phosphate metabolic process

[Term]
id: GO:0009133
name: nucleoside diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "nucleoside diphosphate anabolism" EXACT []
synonym: "nucleoside diphosphate biosynthesis" EXACT []
synonym: "nucleoside diphosphate formation" EXACT []
synonym: "nucleoside diphosphate synthesis" EXACT []
is_a: GO:0009132 ! nucleoside diphosphate metabolic process
is_a: GO:1901293 ! nucleoside phosphate biosynthetic process

[Term]
id: GO:0009134
name: nucleoside diphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "nucleoside diphosphate breakdown" EXACT []
synonym: "nucleoside diphosphate catabolism" EXACT []
synonym: "nucleoside diphosphate degradation" EXACT []
is_a: GO:0009132 ! nucleoside diphosphate metabolic process
is_a: GO:1901292 ! nucleoside phosphate catabolic process

[Term]
id: GO:0009135
name: purine nucleoside diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "purine nucleoside diphosphate metabolism" EXACT []
is_a: GO:0009132 ! nucleoside diphosphate metabolic process

[Term]
id: GO:0009136
name: purine nucleoside diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "purine nucleoside diphosphate anabolism" EXACT []
synonym: "purine nucleoside diphosphate biosynthesis" EXACT []
synonym: "purine nucleoside diphosphate formation" EXACT []
synonym: "purine nucleoside diphosphate synthesis" EXACT []
is_a: GO:0009133 ! nucleoside diphosphate biosynthetic process
is_a: GO:0009135 ! purine nucleoside diphosphate metabolic process

[Term]
id: GO:0009137
name: purine nucleoside diphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "purine nucleoside diphosphate breakdown" EXACT []
synonym: "purine nucleoside diphosphate catabolism" EXACT []
synonym: "purine nucleoside diphosphate degradation" EXACT []
is_a: GO:0009134 ! nucleoside diphosphate catabolic process
is_a: GO:0009135 ! purine nucleoside diphosphate metabolic process

[Term]
id: GO:0009138
name: pyrimidine nucleoside diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pyrimidine nucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "pyrimidine nucleoside diphosphate metabolism" EXACT []
is_a: GO:0009132 ! nucleoside diphosphate metabolic process

[Term]
id: GO:0009139
name: pyrimidine nucleoside diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "pyrimidine nucleoside diphosphate anabolism" EXACT []
synonym: "pyrimidine nucleoside diphosphate biosynthesis" EXACT []
synonym: "pyrimidine nucleoside diphosphate formation" EXACT []
synonym: "pyrimidine nucleoside diphosphate synthesis" EXACT []
is_a: GO:0009133 ! nucleoside diphosphate biosynthetic process
is_a: GO:0009138 ! pyrimidine nucleoside diphosphate metabolic process

[Term]
id: GO:0009140
name: pyrimidine nucleoside diphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "pyrimidine nucleoside diphosphate breakdown" EXACT []
synonym: "pyrimidine nucleoside diphosphate catabolism" EXACT []
synonym: "pyrimidine nucleoside diphosphate degradation" EXACT []
is_a: GO:0009134 ! nucleoside diphosphate catabolic process
is_a: GO:0009138 ! pyrimidine nucleoside diphosphate metabolic process

[Term]
id: GO:0009141
name: nucleoside triphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "nucleoside triphosphate metabolism" EXACT []
is_a: GO:0006753 ! nucleoside phosphate metabolic process

[Term]
id: GO:0009142
name: nucleoside triphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "nucleoside triphosphate anabolism" EXACT []
synonym: "nucleoside triphosphate biosynthesis" EXACT []
synonym: "nucleoside triphosphate formation" EXACT []
synonym: "nucleoside triphosphate synthesis" EXACT []
is_a: GO:0009141 ! nucleoside triphosphate metabolic process
is_a: GO:1901293 ! nucleoside phosphate biosynthetic process

[Term]
id: GO:0009143
name: nucleoside triphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "nucleoside triphosphate breakdown" EXACT []
synonym: "nucleoside triphosphate catabolism" EXACT []
synonym: "nucleoside triphosphate degradation" EXACT []
is_a: GO:0009141 ! nucleoside triphosphate metabolic process
is_a: GO:1901292 ! nucleoside phosphate catabolic process

[Term]
id: GO:0009144
name: purine nucleoside triphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "purine nucleoside triphosphate metabolism" EXACT []
is_a: GO:0009141 ! nucleoside triphosphate metabolic process

[Term]
id: GO:0009145
name: purine nucleoside triphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "purine nucleoside triphosphate anabolism" EXACT []
synonym: "purine nucleoside triphosphate biosynthesis" EXACT []
synonym: "purine nucleoside triphosphate formation" EXACT []
synonym: "purine nucleoside triphosphate synthesis" EXACT []
is_a: GO:0009142 ! nucleoside triphosphate biosynthetic process
is_a: GO:0009144 ! purine nucleoside triphosphate metabolic process

[Term]
id: GO:0009146
name: purine nucleoside triphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "purine nucleoside triphosphate breakdown" EXACT []
synonym: "purine nucleoside triphosphate catabolism" EXACT []
synonym: "purine nucleoside triphosphate degradation" EXACT []
is_a: GO:0009143 ! nucleoside triphosphate catabolic process
is_a: GO:0009144 ! purine nucleoside triphosphate metabolic process

[Term]
id: GO:0009147
name: pyrimidine nucleoside triphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "pyrimidine nucleoside triphosphate metabolism" EXACT []
is_a: GO:0009141 ! nucleoside triphosphate metabolic process

[Term]
id: GO:0009148
name: pyrimidine nucleoside triphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "pyrimidine nucleoside triphosphate anabolism" EXACT []
synonym: "pyrimidine nucleoside triphosphate biosynthesis" EXACT []
synonym: "pyrimidine nucleoside triphosphate formation" EXACT []
synonym: "pyrimidine nucleoside triphosphate synthesis" EXACT []
is_a: GO:0009142 ! nucleoside triphosphate biosynthetic process
is_a: GO:0009147 ! pyrimidine nucleoside triphosphate metabolic process

[Term]
id: GO:0009149
name: pyrimidine nucleoside triphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "pyrimidine nucleoside triphosphate breakdown" EXACT []
synonym: "pyrimidine nucleoside triphosphate catabolism" EXACT []
synonym: "pyrimidine nucleoside triphosphate degradation" EXACT []
is_a: GO:0009143 ! nucleoside triphosphate catabolic process
is_a: GO:0009147 ! pyrimidine nucleoside triphosphate metabolic process

[Term]
id: GO:0009150
name: purine ribonucleotide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "purine ribonucleotide metabolism" EXACT []
is_a: GO:0006163 ! purine nucleotide metabolic process
is_a: GO:0009259 ! ribonucleotide metabolic process

[Term]
id: GO:0009151
name: purine deoxyribonucleotide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "purine deoxyribonucleotide metabolism" EXACT []
is_a: GO:0006163 ! purine nucleotide metabolic process
is_a: GO:0009394 ! 2'-deoxyribonucleotide metabolic process

[Term]
id: GO:0009152
name: purine ribonucleotide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "purine ribonucleotide anabolism" EXACT []
synonym: "purine ribonucleotide biosynthesis" EXACT []
synonym: "purine ribonucleotide formation" EXACT []
synonym: "purine ribonucleotide synthesis" EXACT []
is_a: GO:0006164 ! purine nucleotide biosynthetic process
is_a: GO:0009150 ! purine ribonucleotide metabolic process
is_a: GO:0009260 ! ribonucleotide biosynthetic process

[Term]
id: GO:0009153
name: purine deoxyribonucleotide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "purine deoxyribonucleotide anabolism" EXACT []
synonym: "purine deoxyribonucleotide biosynthesis" EXACT []
synonym: "purine deoxyribonucleotide formation" EXACT []
synonym: "purine deoxyribonucleotide synthesis" EXACT []
is_a: GO:0006164 ! purine nucleotide biosynthetic process
is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process
is_a: GO:0009265 ! 2'-deoxyribonucleotide biosynthetic process

[Term]
id: GO:0009154
name: purine ribonucleotide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "purine ribonucleotide breakdown" EXACT []
synonym: "purine ribonucleotide catabolism" EXACT []
synonym: "purine ribonucleotide degradation" EXACT []
is_a: GO:0006195 ! purine nucleotide catabolic process
is_a: GO:0009150 ! purine ribonucleotide metabolic process
is_a: GO:0009261 ! ribonucleotide catabolic process

[Term]
id: GO:0009155
name: purine deoxyribonucleotide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "purine deoxyribonucleotide breakdown" EXACT []
synonym: "purine deoxyribonucleotide catabolism" EXACT []
synonym: "purine deoxyribonucleotide degradation" EXACT []
is_a: GO:0006195 ! purine nucleotide catabolic process
is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process
is_a: GO:0009264 ! deoxyribonucleotide catabolic process
is_a: GO:0046386 ! deoxyribose phosphate catabolic process

[Term]
id: GO:0009156
name: ribonucleoside monophosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "ribonucleoside monophosphate anabolism" EXACT []
synonym: "ribonucleoside monophosphate biosynthesis" EXACT []
synonym: "ribonucleoside monophosphate formation" EXACT []
synonym: "ribonucleoside monophosphate synthesis" EXACT []
is_a: GO:0009124 ! nucleoside monophosphate biosynthetic process
is_a: GO:0009161 ! ribonucleoside monophosphate metabolic process

[Term]
id: GO:0009157
name: deoxyribonucleoside monophosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "deoxyribonucleoside monophosphate anabolism" EXACT []
synonym: "deoxyribonucleoside monophosphate biosynthesis" EXACT []
synonym: "deoxyribonucleoside monophosphate formation" EXACT []
synonym: "deoxyribonucleoside monophosphate synthesis" EXACT []
is_a: GO:0009124 ! nucleoside monophosphate biosynthetic process
is_a: GO:0009162 ! deoxyribonucleoside monophosphate metabolic process

[Term]
id: GO:0009158
name: ribonucleoside monophosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "ribonucleoside monophosphate breakdown" EXACT []
synonym: "ribonucleoside monophosphate catabolism" EXACT []
synonym: "ribonucleoside monophosphate degradation" EXACT []
is_a: GO:0009125 ! nucleoside monophosphate catabolic process
is_a: GO:0009161 ! ribonucleoside monophosphate metabolic process

[Term]
id: GO:0009159
name: deoxyribonucleoside monophosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "deoxyribonucleoside monophosphate breakdown" EXACT []
synonym: "deoxyribonucleoside monophosphate catabolism" EXACT []
synonym: "deoxyribonucleoside monophosphate degradation" EXACT []
is_a: GO:0009125 ! nucleoside monophosphate catabolic process
is_a: GO:0009162 ! deoxyribonucleoside monophosphate metabolic process

[Term]
id: GO:0009161
name: ribonucleoside monophosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "ribonucleoside monophosphate metabolism" EXACT []
is_a: GO:0009123 ! nucleoside monophosphate metabolic process

[Term]
id: GO:0009162
name: deoxyribonucleoside monophosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "deoxyribonucleoside monophosphate metabolism" EXACT []
is_a: GO:0009123 ! nucleoside monophosphate metabolic process

[Term]
id: GO:0009163
name: nucleoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:jl, ISBN:0140512713]
subset: gosubset_prok
synonym: "nucleoside anabolism" EXACT []
synonym: "nucleoside biosynthesis" EXACT []
synonym: "nucleoside formation" EXACT []
synonym: "nucleoside synthesis" EXACT []
is_a: GO:0009116 ! nucleoside metabolic process
is_a: GO:0034654 ! nucleobase-containing compound biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process
is_a: GO:1901659 ! glycosyl compound biosynthetic process

[Term]
id: GO:0009164
name: nucleoside catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:jl]
subset: gosubset_prok
synonym: "nucleoside breakdown" EXACT []
synonym: "nucleoside catabolism" EXACT []
synonym: "nucleoside degradation" EXACT []
is_a: GO:0009116 ! nucleoside metabolic process
is_a: GO:0034655 ! nucleobase-containing compound catabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process
is_a: GO:1901658 ! glycosyl compound catabolic process

[Term]
id: GO:0009165
name: nucleotide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators]
subset: gosubset_prok
synonym: "nucleotide anabolism" EXACT []
synonym: "nucleotide biosynthesis" EXACT []
synonym: "nucleotide formation" EXACT []
synonym: "nucleotide synthesis" EXACT []
is_a: GO:0009117 ! nucleotide metabolic process
is_a: GO:1901293 ! nucleoside phosphate biosynthetic process

[Term]
id: GO:0009166
name: nucleotide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators]
subset: gosubset_prok
synonym: "nucleotide breakdown" EXACT []
synonym: "nucleotide catabolism" EXACT []
synonym: "nucleotide degradation" EXACT []
is_a: GO:0009117 ! nucleotide metabolic process
is_a: GO:1901292 ! nucleoside phosphate catabolic process

[Term]
id: GO:0009167
name: purine ribonucleoside monophosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "purine ribonucleoside monophosphate metabolism" EXACT []
is_a: GO:0009126 ! purine nucleoside monophosphate metabolic process
is_a: GO:0009161 ! ribonucleoside monophosphate metabolic process

[Term]
id: GO:0009168
name: purine ribonucleoside monophosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "purine ribonucleoside monophosphate anabolism" EXACT []
synonym: "purine ribonucleoside monophosphate biosynthesis" EXACT []
synonym: "purine ribonucleoside monophosphate formation" EXACT []
synonym: "purine ribonucleoside monophosphate synthesis" EXACT []
xref: Reactome:REACT_103616 "Purine ribonucleoside monophosphate biosynthesis, Danio rerio"
xref: Reactome:REACT_105374 "Purine ribonucleoside monophosphate biosynthesis, Saccharomyces cerevisiae"
xref: Reactome:REACT_106062 "Purine ribonucleoside monophosphate biosynthesis, Taeniopygia guttata"
xref: Reactome:REACT_106423 "Purine ribonucleoside monophosphate biosynthesis, Gallus gallus"
xref: Reactome:REACT_107566 "Purine ribonucleoside monophosphate biosynthesis, Dictyostelium discoideum"
xref: Reactome:REACT_108408 "Purine ribonucleoside monophosphate biosynthesis, Mus musculus"
xref: Reactome:REACT_1776 "Purine ribonucleoside monophosphate biosynthesis, Homo sapiens"
xref: Reactome:REACT_28359 "Purine ribonucleoside monophosphate biosynthesis, Canis familiaris"
xref: Reactome:REACT_30059 "Purine ribonucleoside monophosphate biosynthesis, Rattus norvegicus"
xref: Reactome:REACT_30811 "Purine ribonucleoside monophosphate biosynthesis, Xenopus tropicalis"
xref: Reactome:REACT_32997 "Purine ribonucleoside monophosphate biosynthesis, Escherichia coli"
xref: Reactome:REACT_33659 "Purine ribonucleoside monophosphate biosynthesis, Sus scrofa"
xref: Reactome:REACT_79911 "Purine ribonucleoside monophosphate biosynthesis, Arabidopsis thaliana"
xref: Reactome:REACT_80409 "Purine ribonucleoside monophosphate biosynthesis, Caenorhabditis elegans"
xref: Reactome:REACT_83164 "Purine ribonucleoside monophosphate biosynthesis, Plasmodium falciparum"
xref: Reactome:REACT_84816 "Purine ribonucleoside monophosphate biosynthesis, Mycobacterium tuberculosis"
xref: Reactome:REACT_87285 "Purine ribonucleoside monophosphate biosynthesis, Staphylococcus aureus N315"
xref: Reactome:REACT_92581 "Purine ribonucleoside monophosphate biosynthesis, Bos taurus"
xref: Reactome:REACT_92811 "Purine ribonucleoside monophosphate biosynthesis, Schizosaccharomyces pombe"
xref: Reactome:REACT_93080 "Purine ribonucleoside monophosphate biosynthesis, Oryza sativa"
xref: Reactome:REACT_96162 "Purine ribonucleoside monophosphate biosynthesis, Drosophila melanogaster"
is_a: GO:0009127 ! purine nucleoside monophosphate biosynthetic process
is_a: GO:0009156 ! ribonucleoside monophosphate biosynthetic process
is_a: GO:0009167 ! purine ribonucleoside monophosphate metabolic process

[Term]
id: GO:0009169
name: purine ribonucleoside monophosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "purine ribonucleoside monophosphate breakdown" EXACT []
synonym: "purine ribonucleoside monophosphate catabolism" EXACT []
synonym: "purine ribonucleoside monophosphate degradation" EXACT []
is_a: GO:0009128 ! purine nucleoside monophosphate catabolic process
is_a: GO:0009158 ! ribonucleoside monophosphate catabolic process
is_a: GO:0009167 ! purine ribonucleoside monophosphate metabolic process

[Term]
id: GO:0009170
name: purine deoxyribonucleoside monophosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving purine deoxyribonucleoside monophosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "purine deoxyribonucleoside monophosphate metabolism" EXACT []
is_a: GO:0009126 ! purine nucleoside monophosphate metabolic process
is_a: GO:0009162 ! deoxyribonucleoside monophosphate metabolic process

[Term]
id: GO:0009171
name: purine deoxyribonucleoside monophosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of purine deoxyribonucleoside monophosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "purine deoxyribonucleoside monophosphate anabolism" EXACT []
synonym: "purine deoxyribonucleoside monophosphate biosynthesis" EXACT []
synonym: "purine deoxyribonucleoside monophosphate formation" EXACT []
synonym: "purine deoxyribonucleoside monophosphate synthesis" EXACT []
is_a: GO:0009127 ! purine nucleoside monophosphate biosynthetic process
is_a: GO:0009157 ! deoxyribonucleoside monophosphate biosynthetic process
is_a: GO:0009170 ! purine deoxyribonucleoside monophosphate metabolic process

[Term]
id: GO:0009172
name: purine deoxyribonucleoside monophosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleoside monophosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "purine deoxyribonucleoside monophosphate breakdown" EXACT []
synonym: "purine deoxyribonucleoside monophosphate catabolism" EXACT []
synonym: "purine deoxyribonucleoside monophosphate degradation" EXACT []
is_a: GO:0009128 ! purine nucleoside monophosphate catabolic process
is_a: GO:0009159 ! deoxyribonucleoside monophosphate catabolic process
is_a: GO:0009170 ! purine deoxyribonucleoside monophosphate metabolic process

[Term]
id: GO:0009173
name: pyrimidine ribonucleoside monophosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pyrimidine ribonucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "pyrimidine ribonucleoside monophosphate metabolism" EXACT []
is_a: GO:0009129 ! pyrimidine nucleoside monophosphate metabolic process
is_a: GO:0009161 ! ribonucleoside monophosphate metabolic process

[Term]
id: GO:0009174
name: pyrimidine ribonucleoside monophosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyrimidine ribonucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "pyrimidine ribonucleoside monophosphate anabolism" EXACT []
synonym: "pyrimidine ribonucleoside monophosphate biosynthesis" EXACT []
synonym: "pyrimidine ribonucleoside monophosphate formation" EXACT []
synonym: "pyrimidine ribonucleoside monophosphate synthesis" EXACT []
is_a: GO:0009130 ! pyrimidine nucleoside monophosphate biosynthetic process
is_a: GO:0009156 ! ribonucleoside monophosphate biosynthetic process
is_a: GO:0009173 ! pyrimidine ribonucleoside monophosphate metabolic process

[Term]
id: GO:0009175
name: pyrimidine ribonucleoside monophosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine ribonucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "pyrimidine ribonucleoside monophosphate breakdown" EXACT []
synonym: "pyrimidine ribonucleoside monophosphate catabolism" EXACT []
synonym: "pyrimidine ribonucleoside monophosphate degradation" EXACT []
is_a: GO:0009131 ! pyrimidine nucleoside monophosphate catabolic process
is_a: GO:0009158 ! ribonucleoside monophosphate catabolic process
is_a: GO:0009173 ! pyrimidine ribonucleoside monophosphate metabolic process

[Term]
id: GO:0009176
name: pyrimidine deoxyribonucleoside monophosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pyrimidine deoxynucleoside monophosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "pyrimidine deoxyribonucleoside monophosphate metabolism" EXACT []
is_a: GO:0009129 ! pyrimidine nucleoside monophosphate metabolic process
is_a: GO:0009162 ! deoxyribonucleoside monophosphate metabolic process

[Term]
id: GO:0009177
name: pyrimidine deoxyribonucleoside monophosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyrimidine deoxynucleoside monophosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "pyrimidine deoxyribonucleoside monophosphate anabolism" EXACT []
synonym: "pyrimidine deoxyribonucleoside monophosphate biosynthesis" EXACT []
synonym: "pyrimidine deoxyribonucleoside monophosphate formation" EXACT []
synonym: "pyrimidine deoxyribonucleoside monophosphate synthesis" EXACT []
is_a: GO:0009130 ! pyrimidine nucleoside monophosphate biosynthetic process
is_a: GO:0009157 ! deoxyribonucleoside monophosphate biosynthetic process
is_a: GO:0009176 ! pyrimidine deoxyribonucleoside monophosphate metabolic process

[Term]
id: GO:0009178
name: pyrimidine deoxyribonucleoside monophosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine deoxynucleoside monophosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "pyrimidine deoxyribonucleoside monophosphate breakdown" EXACT []
synonym: "pyrimidine deoxyribonucleoside monophosphate catabolism" EXACT []
synonym: "pyrimidine deoxyribonucleoside monophosphate degradation" EXACT []
is_a: GO:0009131 ! pyrimidine nucleoside monophosphate catabolic process
is_a: GO:0009159 ! deoxyribonucleoside monophosphate catabolic process
is_a: GO:0009176 ! pyrimidine deoxyribonucleoside monophosphate metabolic process

[Term]
id: GO:0009179
name: purine ribonucleoside diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "purine ribonucleoside diphosphate metabolism" EXACT []
is_a: GO:0009135 ! purine nucleoside diphosphate metabolic process
is_a: GO:0009185 ! ribonucleoside diphosphate metabolic process

[Term]
id: GO:0009180
name: purine ribonucleoside diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "purine ribonucleoside diphosphate anabolism" EXACT []
synonym: "purine ribonucleoside diphosphate biosynthesis" EXACT []
synonym: "purine ribonucleoside diphosphate formation" EXACT []
synonym: "purine ribonucleoside diphosphate synthesis" EXACT []
is_a: GO:0009136 ! purine nucleoside diphosphate biosynthetic process
is_a: GO:0009179 ! purine ribonucleoside diphosphate metabolic process
is_a: GO:0009188 ! ribonucleoside diphosphate biosynthetic process

[Term]
id: GO:0009181
name: purine ribonucleoside diphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "purine ribonucleoside diphosphate breakdown" EXACT []
synonym: "purine ribonucleoside diphosphate catabolism" EXACT []
synonym: "purine ribonucleoside diphosphate degradation" EXACT []
is_a: GO:0009137 ! purine nucleoside diphosphate catabolic process
is_a: GO:0009179 ! purine ribonucleoside diphosphate metabolic process
is_a: GO:0009191 ! ribonucleoside diphosphate catabolic process

[Term]
id: GO:0009182
name: purine deoxyribonucleoside diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving purine deoxyribonucleoside diphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "purine deoxyribonucleoside diphosphate metabolism" EXACT []
is_a: GO:0009135 ! purine nucleoside diphosphate metabolic process
is_a: GO:0009186 ! deoxyribonucleoside diphosphate metabolic process

[Term]
id: GO:0009183
name: purine deoxyribonucleoside diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of purine deoxyribonucleoside diphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "purine deoxyribonucleoside diphosphate anabolism" EXACT []
synonym: "purine deoxyribonucleoside diphosphate biosynthesis" EXACT []
synonym: "purine deoxyribonucleoside diphosphate formation" EXACT []
synonym: "purine deoxyribonucleoside diphosphate synthesis" EXACT []
is_a: GO:0009136 ! purine nucleoside diphosphate biosynthetic process
is_a: GO:0009182 ! purine deoxyribonucleoside diphosphate metabolic process
is_a: GO:0009189 ! deoxyribonucleoside diphosphate biosynthetic process

[Term]
id: GO:0009184
name: purine deoxyribonucleoside diphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleoside diphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "purine deoxyribonucleoside diphosphate breakdown" EXACT []
synonym: "purine deoxyribonucleoside diphosphate catabolism" EXACT []
synonym: "purine deoxyribonucleoside diphosphate degradation" EXACT []
is_a: GO:0009137 ! purine nucleoside diphosphate catabolic process
is_a: GO:0009182 ! purine deoxyribonucleoside diphosphate metabolic process
is_a: GO:0009192 ! deoxyribonucleoside diphosphate catabolic process

[Term]
id: GO:0009185
name: ribonucleoside diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "ribonucleoside diphosphate metabolism" EXACT []
is_a: GO:0009132 ! nucleoside diphosphate metabolic process

[Term]
id: GO:0009186
name: deoxyribonucleoside diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a deoxyribonucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "deoxyribonucleoside diphosphate metabolism" EXACT []
is_a: GO:0009132 ! nucleoside diphosphate metabolic process

[Term]
id: GO:0009187
name: cyclic nucleotide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "cyclic nucleotide metabolism" EXACT []
is_a: GO:0009117 ! nucleotide metabolic process

[Term]
id: GO:0009188
name: ribonucleoside diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "ribonucleoside diphosphate anabolism" EXACT []
synonym: "ribonucleoside diphosphate biosynthesis" EXACT []
synonym: "ribonucleoside diphosphate formation" EXACT []
synonym: "ribonucleoside diphosphate synthesis" EXACT []
is_a: GO:0009133 ! nucleoside diphosphate biosynthetic process
is_a: GO:0009185 ! ribonucleoside diphosphate metabolic process

[Term]
id: GO:0009189
name: deoxyribonucleoside diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "deoxyribonucleoside diphosphate anabolism" EXACT []
synonym: "deoxyribonucleoside diphosphate biosynthesis" EXACT []
synonym: "deoxyribonucleoside diphosphate formation" EXACT []
synonym: "deoxyribonucleoside diphosphate synthesis" EXACT []
is_a: GO:0009133 ! nucleoside diphosphate biosynthetic process
is_a: GO:0009186 ! deoxyribonucleoside diphosphate metabolic process

[Term]
id: GO:0009190
name: cyclic nucleotide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "cyclic nucleotide anabolism" EXACT []
synonym: "cyclic nucleotide biosynthesis" EXACT []
synonym: "cyclic nucleotide formation" EXACT []
synonym: "cyclic nucleotide synthesis" EXACT []
is_a: GO:0009165 ! nucleotide biosynthetic process
is_a: GO:0009187 ! cyclic nucleotide metabolic process

[Term]
id: GO:0009191
name: ribonucleoside diphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "ribonucleoside diphosphate breakdown" EXACT []
synonym: "ribonucleoside diphosphate catabolism" EXACT []
synonym: "ribonucleoside diphosphate degradation" EXACT []
is_a: GO:0009134 ! nucleoside diphosphate catabolic process
is_a: GO:0009185 ! ribonucleoside diphosphate metabolic process

[Term]
id: GO:0009192
name: deoxyribonucleoside diphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "deoxyribonucleoside diphosphate breakdown" EXACT []
synonym: "deoxyribonucleoside diphosphate catabolism" EXACT []
synonym: "deoxyribonucleoside diphosphate degradation" EXACT []
is_a: GO:0009134 ! nucleoside diphosphate catabolic process
is_a: GO:0009186 ! deoxyribonucleoside diphosphate metabolic process

[Term]
id: GO:0009193
name: pyrimidine ribonucleoside diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pyrimidine ribonucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "pyrimidine ribonucleoside diphosphate metabolism" EXACT []
is_a: GO:0009138 ! pyrimidine nucleoside diphosphate metabolic process
is_a: GO:0009185 ! ribonucleoside diphosphate metabolic process

[Term]
id: GO:0009194
name: pyrimidine ribonucleoside diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyrimidine ribonucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "pyrimidine ribonucleoside diphosphate anabolism" EXACT []
synonym: "pyrimidine ribonucleoside diphosphate biosynthesis" EXACT []
synonym: "pyrimidine ribonucleoside diphosphate formation" EXACT []
synonym: "pyrimidine ribonucleoside diphosphate synthesis" EXACT []
is_a: GO:0009139 ! pyrimidine nucleoside diphosphate biosynthetic process
is_a: GO:0009188 ! ribonucleoside diphosphate biosynthetic process
is_a: GO:0009193 ! pyrimidine ribonucleoside diphosphate metabolic process

[Term]
id: GO:0009195
name: pyrimidine ribonucleoside diphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine ribonucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "pyrimidine ribonucleoside diphosphate breakdown" EXACT []
synonym: "pyrimidine ribonucleoside diphosphate catabolism" EXACT []
synonym: "pyrimidine ribonucleoside diphosphate degradation" EXACT []
is_a: GO:0009140 ! pyrimidine nucleoside diphosphate catabolic process
is_a: GO:0009191 ! ribonucleoside diphosphate catabolic process
is_a: GO:0009193 ! pyrimidine ribonucleoside diphosphate metabolic process

[Term]
id: GO:0009196
name: pyrimidine deoxyribonucleoside diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pyrimidine deoxynucleoside diphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "pyrimidine deoxyribonucleoside diphosphate metabolism" EXACT []
is_a: GO:0009138 ! pyrimidine nucleoside diphosphate metabolic process
is_a: GO:0009186 ! deoxyribonucleoside diphosphate metabolic process

[Term]
id: GO:0009197
name: pyrimidine deoxyribonucleoside diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyrimidine deoxyribonucleoside diphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "pyrimidine deoxyribonucleoside diphosphate anabolism" EXACT []
synonym: "pyrimidine deoxyribonucleoside diphosphate biosynthesis" EXACT []
synonym: "pyrimidine deoxyribonucleoside diphosphate formation" EXACT []
synonym: "pyrimidine deoxyribonucleoside diphosphate synthesis" EXACT []
is_a: GO:0009139 ! pyrimidine nucleoside diphosphate biosynthetic process
is_a: GO:0009189 ! deoxyribonucleoside diphosphate biosynthetic process
is_a: GO:0009196 ! pyrimidine deoxyribonucleoside diphosphate metabolic process

[Term]
id: GO:0009198
name: pyrimidine deoxyribonucleoside diphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine deoxynucleoside diphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "pyrimidine deoxyribonucleoside diphosphate breakdown" EXACT []
synonym: "pyrimidine deoxyribonucleoside diphosphate catabolism" EXACT []
synonym: "pyrimidine deoxyribonucleoside diphosphate degradation" EXACT []
is_a: GO:0009140 ! pyrimidine nucleoside diphosphate catabolic process
is_a: GO:0009192 ! deoxyribonucleoside diphosphate catabolic process
is_a: GO:0009196 ! pyrimidine deoxyribonucleoside diphosphate metabolic process

[Term]
id: GO:0009199
name: ribonucleoside triphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "ribonucleoside triphosphate metabolism" EXACT []
is_a: GO:0009141 ! nucleoside triphosphate metabolic process

[Term]
id: GO:0009200
name: deoxyribonucleoside triphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a deoxyribonucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "deoxyribonucleoside triphosphate metabolism" EXACT []
is_a: GO:0009141 ! nucleoside triphosphate metabolic process

[Term]
id: GO:0009201
name: ribonucleoside triphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "ribonucleoside triphosphate anabolism" EXACT []
synonym: "ribonucleoside triphosphate biosynthesis" EXACT []
synonym: "ribonucleoside triphosphate formation" EXACT []
synonym: "ribonucleoside triphosphate synthesis" EXACT []
is_a: GO:0009142 ! nucleoside triphosphate biosynthetic process
is_a: GO:0009199 ! ribonucleoside triphosphate metabolic process

[Term]
id: GO:0009202
name: deoxyribonucleoside triphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "deoxyribonucleoside triphosphate anabolism" EXACT []
synonym: "deoxyribonucleoside triphosphate biosynthesis" EXACT []
synonym: "deoxyribonucleoside triphosphate formation" EXACT []
synonym: "deoxyribonucleoside triphosphate synthesis" EXACT []
is_a: GO:0009142 ! nucleoside triphosphate biosynthetic process
is_a: GO:0009200 ! deoxyribonucleoside triphosphate metabolic process

[Term]
id: GO:0009203
name: ribonucleoside triphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "ribonucleoside triphosphate breakdown" EXACT []
synonym: "ribonucleoside triphosphate catabolism" EXACT []
synonym: "ribonucleoside triphosphate degradation" EXACT []
is_a: GO:0009143 ! nucleoside triphosphate catabolic process
is_a: GO:0009199 ! ribonucleoside triphosphate metabolic process

[Term]
id: GO:0009204
name: deoxyribonucleoside triphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "deoxyribonucleoside triphosphate breakdown" EXACT []
synonym: "deoxyribonucleoside triphosphate catabolism" EXACT []
synonym: "deoxyribonucleoside triphosphate degradation" EXACT []
is_a: GO:0009143 ! nucleoside triphosphate catabolic process
is_a: GO:0009200 ! deoxyribonucleoside triphosphate metabolic process

[Term]
id: GO:0009205
name: purine ribonucleoside triphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "purine ribonucleoside triphosphate metabolism" EXACT []
is_a: GO:0009144 ! purine nucleoside triphosphate metabolic process
is_a: GO:0009199 ! ribonucleoside triphosphate metabolic process

[Term]
id: GO:0009206
name: purine ribonucleoside triphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "purine ribonucleoside triphosphate anabolism" EXACT []
synonym: "purine ribonucleoside triphosphate biosynthesis" EXACT []
synonym: "purine ribonucleoside triphosphate formation" EXACT []
synonym: "purine ribonucleoside triphosphate synthesis" EXACT []
is_a: GO:0009145 ! purine nucleoside triphosphate biosynthetic process
is_a: GO:0009201 ! ribonucleoside triphosphate biosynthetic process
is_a: GO:0009205 ! purine ribonucleoside triphosphate metabolic process

[Term]
id: GO:0009207
name: purine ribonucleoside triphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "purine ribonucleoside triphosphate breakdown" EXACT []
synonym: "purine ribonucleoside triphosphate catabolism" EXACT []
synonym: "purine ribonucleoside triphosphate degradation" EXACT []
is_a: GO:0009146 ! purine nucleoside triphosphate catabolic process
is_a: GO:0009203 ! ribonucleoside triphosphate catabolic process
is_a: GO:0009205 ! purine ribonucleoside triphosphate metabolic process

[Term]
id: GO:0009208
name: pyrimidine ribonucleoside triphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pyrimidine ribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "pyrimidine ribonucleoside triphosphate metabolism" EXACT []
is_a: GO:0009147 ! pyrimidine nucleoside triphosphate metabolic process
is_a: GO:0009199 ! ribonucleoside triphosphate metabolic process

[Term]
id: GO:0009209
name: pyrimidine ribonucleoside triphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyrimidine ribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "pyrimidine ribonucleoside triphosphate anabolism" EXACT []
synonym: "pyrimidine ribonucleoside triphosphate biosynthesis" EXACT []
synonym: "pyrimidine ribonucleoside triphosphate formation" EXACT []
synonym: "pyrimidine ribonucleoside triphosphate synthesis" EXACT []
is_a: GO:0009148 ! pyrimidine nucleoside triphosphate biosynthetic process
is_a: GO:0009201 ! ribonucleoside triphosphate biosynthetic process
is_a: GO:0009208 ! pyrimidine ribonucleoside triphosphate metabolic process

[Term]
id: GO:0009210
name: pyrimidine ribonucleoside triphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine ribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "pyrimidine ribonucleoside triphosphate breakdown" EXACT []
synonym: "pyrimidine ribonucleoside triphosphate catabolism" EXACT []
synonym: "pyrimidine ribonucleoside triphosphate degradation" EXACT []
is_a: GO:0009149 ! pyrimidine nucleoside triphosphate catabolic process
is_a: GO:0009203 ! ribonucleoside triphosphate catabolic process
is_a: GO:0009208 ! pyrimidine ribonucleoside triphosphate metabolic process

[Term]
id: GO:0009211
name: pyrimidine deoxyribonucleoside triphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pyrimidine deoxyribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "pyrimidine deoxyribonucleoside triphosphate metabolism" EXACT []
is_a: GO:0009147 ! pyrimidine nucleoside triphosphate metabolic process
is_a: GO:0009200 ! deoxyribonucleoside triphosphate metabolic process

[Term]
id: GO:0009212
name: pyrimidine deoxyribonucleoside triphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyrimidine deoxyribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "pyrimidine deoxyribonucleoside triphosphate anabolism" EXACT []
synonym: "pyrimidine deoxyribonucleoside triphosphate biosynthesis" EXACT []
synonym: "pyrimidine deoxyribonucleoside triphosphate formation" EXACT []
synonym: "pyrimidine deoxyribonucleoside triphosphate synthesis" EXACT []
is_a: GO:0009148 ! pyrimidine nucleoside triphosphate biosynthetic process
is_a: GO:0009202 ! deoxyribonucleoside triphosphate biosynthetic process
is_a: GO:0009211 ! pyrimidine deoxyribonucleoside triphosphate metabolic process

[Term]
id: GO:0009213
name: pyrimidine deoxyribonucleoside triphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine deoxyribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "pyrimidine deoxyribonucleoside triphosphate breakdown" EXACT []
synonym: "pyrimidine deoxyribonucleoside triphosphate catabolism" EXACT []
synonym: "pyrimidine deoxyribonucleoside triphosphate degradation" EXACT []
is_a: GO:0009149 ! pyrimidine nucleoside triphosphate catabolic process
is_a: GO:0009204 ! deoxyribonucleoside triphosphate catabolic process
is_a: GO:0009211 ! pyrimidine deoxyribonucleoside triphosphate metabolic process

[Term]
id: GO:0009214
name: cyclic nucleotide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "cyclic nucleotide breakdown" EXACT []
synonym: "cyclic nucleotide catabolism" EXACT []
synonym: "cyclic nucleotide degradation" EXACT []
is_a: GO:0009166 ! nucleotide catabolic process
is_a: GO:0009187 ! cyclic nucleotide metabolic process

[Term]
id: GO:0009215
name: purine deoxyribonucleoside triphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving purine deoxyribonucleoside triphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "purine deoxyribonucleoside triphosphate metabolism" EXACT []
is_a: GO:0009144 ! purine nucleoside triphosphate metabolic process
is_a: GO:0009200 ! deoxyribonucleoside triphosphate metabolic process

[Term]
id: GO:0009216
name: purine deoxyribonucleoside triphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of purine deoxyribonucleoside triphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "purine deoxyribonucleoside triphosphate anabolism" EXACT []
synonym: "purine deoxyribonucleoside triphosphate biosynthesis" EXACT []
synonym: "purine deoxyribonucleoside triphosphate formation" EXACT []
synonym: "purine deoxyribonucleoside triphosphate synthesis" EXACT []
is_a: GO:0009145 ! purine nucleoside triphosphate biosynthetic process
is_a: GO:0009202 ! deoxyribonucleoside triphosphate biosynthetic process
is_a: GO:0009215 ! purine deoxyribonucleoside triphosphate metabolic process

[Term]
id: GO:0009217
name: purine deoxyribonucleoside triphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleoside triphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "purine deoxyribonucleoside triphosphate breakdown" EXACT []
synonym: "purine deoxyribonucleoside triphosphate catabolism" EXACT []
synonym: "purine deoxyribonucleoside triphosphate degradation" EXACT []
is_a: GO:0009146 ! purine nucleoside triphosphate catabolic process
is_a: GO:0009204 ! deoxyribonucleoside triphosphate catabolic process
is_a: GO:0009215 ! purine deoxyribonucleoside triphosphate metabolic process

[Term]
id: GO:0009218
name: pyrimidine ribonucleotide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "pyrimidine ribonucleotide metabolism" EXACT []
is_a: GO:0006220 ! pyrimidine nucleotide metabolic process
is_a: GO:0009259 ! ribonucleotide metabolic process

[Term]
id: GO:0009219
name: pyrimidine deoxyribonucleotide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a pyrimidine deoxynucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "pyrimidine deoxyribonucleotide metabolism" EXACT []
is_a: GO:0006220 ! pyrimidine nucleotide metabolic process
is_a: GO:0009394 ! 2'-deoxyribonucleotide metabolic process

[Term]
id: GO:0009220
name: pyrimidine ribonucleotide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "pyrimidine ribonucleotide anabolism" EXACT []
synonym: "pyrimidine ribonucleotide biosynthesis" EXACT []
synonym: "pyrimidine ribonucleotide formation" EXACT []
synonym: "pyrimidine ribonucleotide synthesis" EXACT []
xref: MetaCyc:PWY0-162
is_a: GO:0006221 ! pyrimidine nucleotide biosynthetic process
is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process
is_a: GO:0009260 ! ribonucleotide biosynthetic process

[Term]
id: GO:0009221
name: pyrimidine deoxyribonucleotide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a pyrimidine deoxyribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "pyrimidine deoxyribonucleotide anabolism" EXACT []
synonym: "pyrimidine deoxyribonucleotide biosynthesis" EXACT []
synonym: "pyrimidine deoxyribonucleotide formation" EXACT []
synonym: "pyrimidine deoxyribonucleotide synthesis" EXACT []
xref: MetaCyc:PWY0-166
is_a: GO:0006221 ! pyrimidine nucleotide biosynthetic process
is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process
is_a: GO:0009265 ! 2'-deoxyribonucleotide biosynthetic process

[Term]
id: GO:0009222
name: pyrimidine ribonucleotide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "pyrimidine ribonucleotide breakdown" EXACT []
synonym: "pyrimidine ribonucleotide catabolism" EXACT []
synonym: "pyrimidine ribonucleotide degradation" EXACT []
is_a: GO:0006244 ! pyrimidine nucleotide catabolic process
is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process
is_a: GO:0009261 ! ribonucleotide catabolic process

[Term]
id: GO:0009223
name: pyrimidine deoxyribonucleotide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a pyrimidine deoxyribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "pyrimidine deoxyribonucleotide breakdown" EXACT []
synonym: "pyrimidine deoxyribonucleotide catabolism" EXACT []
synonym: "pyrimidine deoxyribonucleotide degradation" EXACT []
is_a: GO:0006244 ! pyrimidine nucleotide catabolic process
is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process
is_a: GO:0009264 ! deoxyribonucleotide catabolic process
is_a: GO:0046386 ! deoxyribose phosphate catabolic process

[Term]
id: GO:0009224
name: CMP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of CMP, cytidine monophosphate." [ISBN:0198506732]
subset: gosubset_prok
synonym: "CMP anabolism" EXACT []
synonym: "CMP biosynthesis" EXACT []
synonym: "CMP formation" EXACT []
synonym: "CMP synthesis" EXACT []
is_a: GO:0009174 ! pyrimidine ribonucleoside monophosphate biosynthetic process
is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process
is_a: GO:0046035 ! CMP metabolic process
is_a: GO:0046132 ! pyrimidine ribonucleoside biosynthetic process

[Term]
id: GO:0009225
name: nucleotide-sugar metabolic process
namespace: biological_process
def: "The cellular chemical reactions and pathways involving nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
synonym: "nucleotide-sugar metabolism" EXACT []
is_a: GO:0006139 ! nucleobase-containing compound metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:0009226
name: nucleotide-sugar biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [ISBN:0198506732]
subset: gosubset_prok
synonym: "nucleotide-sugar anabolism" EXACT []
synonym: "nucleotide-sugar biosynthesis" EXACT []
synonym: "nucleotide-sugar formation" EXACT []
synonym: "nucleotide-sugar synthesis" EXACT []
is_a: GO:0009225 ! nucleotide-sugar metabolic process
is_a: GO:0034654 ! nucleobase-containing compound biosynthetic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process

[Term]
id: GO:0009227
name: nucleotide-sugar catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [ISBN:0198506732]
subset: gosubset_prok
synonym: "nucleotide-sugar breakdown" EXACT []
synonym: "nucleotide-sugar catabolism" EXACT []
synonym: "nucleotide-sugar degradation" EXACT []
is_a: GO:0009225 ! nucleotide-sugar metabolic process
is_a: GO:0034655 ! nucleobase-containing compound catabolic process
is_a: GO:1901136 ! carbohydrate derivative catabolic process

[Term]
id: GO:0009228
name: thiamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver." [CHEBI:18385, GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "thiamin anabolism" EXACT []
synonym: "thiamin biosynthetic process" EXACT [GOC:curators]
synonym: "thiamine biosynthesis" EXACT [GOC:curators]
synonym: "thiamine formation" EXACT [GOC:curators]
synonym: "thiamine synthesis" EXACT [GOC:curators]
synonym: "vitamin B1 biosynthesis" EXACT []
synonym: "vitamin B1 biosynthetic process" EXACT []
xref: MetaCyc:THISYN-PWY
is_a: GO:0006772 ! thiamine metabolic process
is_a: GO:0042724 ! thiamine-containing compound biosynthetic process

[Term]
id: GO:0009229
name: thiamine diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle." [CHEBI:45931, GOC:jl, ISBN:0140512713]
subset: gosubset_prok
synonym: "thiamin diphosphate biosynthetic process" EXACT [GOC:cuators]
synonym: "thiamin pyrophosphate biosynthesis" EXACT []
synonym: "thiamin pyrophosphate biosynthetic process" EXACT []
synonym: "thiamine diphosphate anabolism" EXACT [GOC:curators]
synonym: "thiamine diphosphate biosynthesis" EXACT [GOC:curators]
synonym: "thiamine diphosphate formation" EXACT [GOC:curators]
synonym: "thiamine diphosphate synthesis" EXACT [GOC:curators]
synonym: "thiamine pyrophosphate biosynthesis" EXACT []
synonym: "thiamine pyrophosphate biosynthetic process" EXACT []
synonym: "TPP biosynthesis" EXACT []
synonym: "TPP biosynthetic process" EXACT []
is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0042357 ! thiamine diphosphate metabolic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:0072528 ! pyrimidine-containing compound biosynthetic process
is_a: GO:0090407 ! organophosphate biosynthetic process

[Term]
id: GO:0009230
name: thiamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver." [CHEBI:18385, GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "thiamin catabolic process" EXACT [GOC:curators]
synonym: "thiamine breakdown" EXACT [GOC:curators]
synonym: "thiamine catabolism" EXACT [GOC:curators]
synonym: "thiamine degradation" EXACT [GOC:curators]
synonym: "vitamin B1 catabolic process" EXACT []
synonym: "vitamin B1 catabolism" EXACT []
is_a: GO:0006772 ! thiamine metabolic process
is_a: GO:0042725 ! thiamine-containing compound catabolic process

[Term]
id: GO:0009231
name: riboflavin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD)." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html]
subset: gosubset_prok
synonym: "riboflavin anabolism" EXACT []
synonym: "riboflavin biosynthesis" EXACT []
synonym: "riboflavin formation" EXACT []
synonym: "riboflavin synthesis" EXACT []
synonym: "vitamin B2 biosynthesis" EXACT []
synonym: "vitamin B2 biosynthetic process" EXACT []
synonym: "vitamin G biosynthesis" EXACT []
synonym: "vitamin G biosynthetic process" EXACT []
xref: MetaCyc:RIBOSYN2-PWY
xref: Wikipedia:Riboflavin
is_a: GO:0006771 ! riboflavin metabolic process
is_a: GO:0042364 ! water-soluble vitamin biosynthetic process
is_a: GO:0042727 ! flavin-containing compound biosynthetic process

[Term]
id: GO:0009232
name: riboflavin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD)." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html]
subset: gosubset_prok
synonym: "riboflavin breakdown" EXACT []
synonym: "riboflavin catabolism" EXACT []
synonym: "riboflavin degradation" EXACT []
synonym: "vitamin B2 catabolic process" EXACT []
synonym: "vitamin B2 catabolism" EXACT []
synonym: "vitamin G catabolic process" EXACT []
synonym: "vitamin G catabolism" EXACT []
is_a: GO:0006771 ! riboflavin metabolic process
is_a: GO:0042365 ! water-soluble vitamin catabolic process
is_a: GO:0042728 ! flavin-containing compound catabolic process

[Term]
id: GO:0009233
name: menaquinone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any of the menaquinones, quinone-derived compounds synthesized by intestinal bacteria. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones have vitamin K activity and are known as vitamin K2." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k]
subset: gosubset_prok
synonym: "menaquinone metabolism" EXACT []
synonym: "menatetrenone metabolic process" EXACT []
synonym: "menatetrenone metabolism" EXACT []
synonym: "multiprenylmenaquinone metabolic process" EXACT []
synonym: "multiprenylmenaquinone metabolism" EXACT []
synonym: "vitamin K2 metabolic process" EXACT []
synonym: "vitamin K2 metabolism" EXACT []
is_a: GO:1901661 ! quinone metabolic process

[Term]
id: GO:0009234
name: menaquinone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any of the menaquinones. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones that have vitamin K activity and are known as vitamin K2." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k]
subset: gosubset_prok
synonym: "menaquinone anabolism" EXACT []
synonym: "menaquinone biosynthesis" EXACT []
synonym: "menaquinone formation" EXACT []
synonym: "menaquinone synthesis" EXACT []
synonym: "menatetrenone biosynthesis" EXACT []
synonym: "menatetrenone biosynthetic process" EXACT []
synonym: "multiprenylmenaquinone biosynthesis" EXACT []
synonym: "multiprenylmenaquinone biosynthetic process" EXACT []
synonym: "vitamin K2 biosynthesis" EXACT []
synonym: "vitamin K2 biosynthetic process" EXACT []
xref: MetaCyc:MENAQUINONESYN-PWY
is_a: GO:0009233 ! menaquinone metabolic process
is_a: GO:1901663 ! quinone biosynthetic process

[Term]
id: GO:0009235
name: cobalamin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:go_curators]
subset: gosubset_prok
synonym: "cobalamin metabolism" EXACT []
synonym: "vitamin B12 metabolic process" EXACT []
synonym: "vitamin B12 metabolism" EXACT []
synonym: "vitamin B12 reduction" NARROW []
is_a: GO:0006767 ! water-soluble vitamin metabolic process
is_a: GO:0033013 ! tetrapyrrole metabolic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0009236
name: cobalamin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "cobalamin anabolism" EXACT []
synonym: "cobalamin biosynthesis" EXACT []
synonym: "cobalamin formation" EXACT []
synonym: "cobalamin synthesis" EXACT []
synonym: "vitamin B12 biosynthesis" EXACT []
synonym: "vitamin B12 biosynthetic process" EXACT []
is_a: GO:0009235 ! cobalamin metabolic process
is_a: GO:0033014 ! tetrapyrrole biosynthetic process
is_a: GO:0042364 ! water-soluble vitamin biosynthetic process

[Term]
id: GO:0009237
name: siderophore metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action." [ISBN:0198547684]
subset: gosubset_prok
synonym: "siderochrome metabolic process" NARROW []
synonym: "siderochrome metabolism" NARROW []
synonym: "siderophore metabolism" EXACT []
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0051186 ! cofactor metabolic process

[Term]
id: GO:0009238
name: enterobactin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway." [ISBN:0198547684]
subset: gosubset_prok
synonym: "enterobactin metabolism" EXACT []
synonym: "enterochelin metabolic process" EXACT []
synonym: "enterochelin metabolism" EXACT []
is_a: GO:0009237 ! siderophore metabolic process
is_a: GO:0009712 ! catechol-containing compound metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0009239
name: enterobactin biosynthetic process
namespace: biological_process
alt_id: GO:0031191
alt_id: GO:0031192
def: "The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway." [GOC:go_curators]
subset: gosubset_prok
synonym: "enterobactin anabolism" EXACT []
synonym: "enterobactin biosynthesis" EXACT []
synonym: "enterobactin biosynthetic process, peptide formation" NARROW []
synonym: "enterobactin biosynthetic process, peptide modification" NARROW []
synonym: "enterobactin formation" EXACT []
synonym: "enterobactin synthesis" EXACT []
synonym: "enterobactin synthetase" RELATED []
synonym: "enterochelin biosynthesis" EXACT []
synonym: "enterochelin biosynthetic process" EXACT []
xref: MetaCyc:ENTBACSYN-PWY
is_a: GO:0009238 ! enterobactin metabolic process
is_a: GO:0009713 ! catechol-containing compound biosynthetic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0019540 ! siderophore biosynthetic process from catechol

[Term]
id: GO:0009240
name: isopentenyl diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, an isomer of dimethylallyl diphosphate and the key precursor of all isoprenoids." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "IPP biosynthesis" EXACT []
synonym: "IPP biosynthetic process" EXACT []
synonym: "isopentenyl diphosphate anabolism" EXACT []
synonym: "isopentenyl diphosphate biosynthesis" EXACT []
synonym: "isopentenyl diphosphate formation" EXACT []
synonym: "isopentenyl diphosphate synthesis" EXACT []
synonym: "isopentenyl pyrophosphate biosynthesis" EXACT []
synonym: "isopentenyl pyrophosphate biosynthetic process" EXACT []
is_a: GO:0008654 ! phospholipid biosynthetic process
is_a: GO:0046490 ! isopentenyl diphosphate metabolic process
relationship: part_of GO:0008299 ! isoprenoid biosynthetic process

[Term]
id: GO:0009242
name: colanic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of colanic acid, a capsular bacterial polysaccharide." [GOC:ai]
subset: gosubset_prok
synonym: "colanic acid anabolism" EXACT []
synonym: "colanic acid biosynthesis" EXACT []
synonym: "colanic acid formation" EXACT []
synonym: "colanic acid synthesis" EXACT []
synonym: "M antigen biosynthesis" EXACT []
synonym: "M antigen biosynthetic process" EXACT []
xref: MetaCyc:COLANSYN-PWY
is_a: GO:0033692 ! cellular polysaccharide biosynthetic process
is_a: GO:0046377 ! colanic acid metabolic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process

[Term]
id: GO:0009243
name: O antigen biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the O side chain of a lipopolysaccharide, which determines the antigenic specificity of the organism. It is made up of about 50 repeating units of a branched tetrasaccharide." [ISBN:0198506732]
subset: gosubset_prok
synonym: "O antigen anabolism" EXACT []
synonym: "O antigen biosynthesis" EXACT []
synonym: "O antigen formation" EXACT []
synonym: "O antigen synthesis" EXACT []
is_a: GO:0033692 ! cellular polysaccharide biosynthetic process
is_a: GO:0046402 ! O antigen metabolic process
relationship: part_of GO:0009103 ! lipopolysaccharide biosynthetic process

[Term]
id: GO:0009244
name: lipopolysaccharide core region biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the core region of bacterial lipopolysaccharides, which contains ten saccharide residues." [ISBN:0198506732]
subset: gosubset_prok
synonym: "lipopolysaccharide core region anabolism" EXACT []
synonym: "lipopolysaccharide core region biosynthesis" EXACT []
synonym: "lipopolysaccharide core region formation" EXACT []
synonym: "lipopolysaccharide core region synthesis" EXACT []
synonym: "LPS core region biosynthetic process" EXACT []
is_a: GO:0009312 ! oligosaccharide biosynthetic process
is_a: GO:0046401 ! lipopolysaccharide core region metabolic process
relationship: part_of GO:0009103 ! lipopolysaccharide biosynthetic process

[Term]
id: GO:0009245
name: lipid A biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid group of bacterial lipopolysaccharides, consisting of six fatty acyl chains linked to two glucosamine residues." [ISBN:0198506732]
subset: gosubset_prok
synonym: "lipid A anabolism" EXACT []
synonym: "lipid A biosynthesis" EXACT []
synonym: "lipid A formation" EXACT []
synonym: "lipid A synthesis" EXACT []
xref: MetaCyc:NAGLIPASYN-PWY
is_a: GO:0008654 ! phospholipid biosynthetic process
is_a: GO:0009247 ! glycolipid biosynthetic process
is_a: GO:0046493 ! lipid A metabolic process
is_a: GO:1901271 ! lipooligosaccharide biosynthetic process

[Term]
id: GO:0009246
name: enterobacterial common antigen biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the enterobacterial common antigen, an acidic polysaccharide containing N-acetyl-D-glucosamine, N-acetyl-D-mannosaminouronic acid, and 4-acetamido-4,6-dideoxy-D-galactose. A major component of the cell wall outer membrane of Gram-negative bacteria." [GOC:ma]
subset: gosubset_prok
synonym: "enterobacterial common antigen anabolism" EXACT []
synonym: "enterobacterial common antigen biosynthesis" EXACT []
synonym: "enterobacterial common antigen formation" EXACT []
synonym: "enterobacterial common antigen synthesis" EXACT []
xref: MetaCyc:ECASYN-PWY
is_a: GO:0033692 ! cellular polysaccharide biosynthetic process
is_a: GO:0046378 ! enterobacterial common antigen metabolic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process

[Term]
id: GO:0009247
name: glycolipid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide)." [CHEBI:33563, GOC:go_curators]
subset: gosubset_prok
synonym: "glycolipid anabolism" EXACT []
synonym: "glycolipid biosynthesis" EXACT []
synonym: "glycolipid formation" EXACT []
synonym: "glycolipid synthesis" EXACT []
xref: MetaCyc:PWY-401
is_a: GO:0006664 ! glycolipid metabolic process
is_a: GO:0046467 ! membrane lipid biosynthetic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process

[Term]
id: GO:0009248
name: K antigen biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a K antigen, a capsular polysaccharide antigen carried on the surface of bacterial capsules that masks somatic (O) antigens." [ISBN:0198506732]
subset: gosubset_prok
synonym: "K antigen anabolism" EXACT []
synonym: "K antigen biosynthesis" EXACT []
synonym: "K antigen formation" EXACT []
synonym: "K antigen synthesis" EXACT []
is_a: GO:0033692 ! cellular polysaccharide biosynthetic process
is_a: GO:0046375 ! K antigen metabolic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process

[Term]
id: GO:0009249
name: protein lipoylation
namespace: biological_process
def: "The addition of a lipoyl group to an amino acid residue in a protein." [GOC:mah]
subset: gosubset_prok
is_a: GO:0018065 ! protein-cofactor linkage

[Term]
id: GO:0009250
name: glucan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues." [GOC:go_curators]
subset: gosubset_prok
synonym: "glucan anabolism" EXACT []
synonym: "glucan biosynthesis" EXACT []
synonym: "glucan formation" EXACT []
synonym: "glucan synthesis" EXACT []
is_a: GO:0006073 ! cellular glucan metabolic process
is_a: GO:0033692 ! cellular polysaccharide biosynthetic process

[Term]
id: GO:0009251
name: glucan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glucans, polysaccharides consisting only of glucose residues." [GOC:go_curators]
subset: gosubset_prok
synonym: "glucan breakdown" EXACT []
synonym: "glucan catabolism" EXACT []
synonym: "glucan degradation" EXACT []
is_a: GO:0000272 ! polysaccharide catabolic process
is_a: GO:0044042 ! glucan metabolic process

[Term]
id: GO:0009252
name: peptidoglycan biosynthetic process
namespace: biological_process
alt_id: GO:0009285
def: "The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732]
subset: gosubset_prok
synonym: "murein biosynthesis" EXACT []
synonym: "murein biosynthetic process" EXACT []
synonym: "peptidoglycan anabolism" EXACT []
synonym: "peptidoglycan biosynthesis" EXACT []
synonym: "peptidoglycan formation" EXACT []
synonym: "peptidoglycan synthesis" EXACT []
is_a: GO:0000270 ! peptidoglycan metabolic process
is_a: GO:0006024 ! glycosaminoglycan biosynthetic process
is_a: GO:0044038 ! cell wall macromolecule biosynthetic process
is_a: GO:0044763 ! single-organism cellular process
relationship: part_of GO:0009273 ! peptidoglycan-based cell wall biogenesis

[Term]
id: GO:0009253
name: peptidoglycan catabolic process
namespace: biological_process
alt_id: GO:0009286
def: "The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732]
subset: gosubset_prok
synonym: "murein catabolic process" EXACT []
synonym: "murein catabolism" EXACT []
synonym: "peptidoglycan breakdown" EXACT []
synonym: "peptidoglycan catabolism" EXACT []
synonym: "peptidoglycan degradation" EXACT []
is_a: GO:0000270 ! peptidoglycan metabolic process
is_a: GO:0006027 ! glycosaminoglycan catabolic process

[Term]
id: GO:0009254
name: peptidoglycan turnover
namespace: biological_process
alt_id: GO:0009287
def: "The continual breakdown and regeneration of peptidoglycan required to maintain the cell wall." [GOC:jl]
subset: gosubset_prok
synonym: "murein turnover" EXACT []
is_a: GO:0000270 ! peptidoglycan metabolic process

[Term]
id: GO:0009255
name: Entner-Doudoroff pathway through 6-phosphogluconate
namespace: biological_process
def: "A pathway that converts a carbohydrate to pyruvate and glyceraldehyde-3 phosphate by producing 6-phosphogluconate and then dehydrating it." [GOC:jl, MetaCyc:ENTNER-DOUDOROFF-PWY-I, PMID:12921356]
subset: gosubset_prok
xref: MetaCyc:ENTNER-DOUDOROFF-PWY-I
xref: PMID:12981024
is_a: GO:0019682 ! glyceraldehyde-3-phosphate metabolic process
is_a: GO:0061678 ! Entner-Doudoroff pathway
relationship: has_part GO:0004456 ! phosphogluconate dehydratase activity

[Term]
id: GO:0009256
name: 10-formyltetrahydrofolate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate." [GOC:ai]
subset: gosubset_prok
synonym: "10-formyl-THF metabolic process" EXACT []
synonym: "10-formyl-THF metabolism" EXACT []
synonym: "10-formyltetrahydrofolate metabolism" EXACT []
is_a: GO:0043648 ! dicarboxylic acid metabolic process
is_a: GO:0046653 ! tetrahydrofolate metabolic process

[Term]
id: GO:0009257
name: 10-formyltetrahydrofolate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate." [GOC:ai]
subset: gosubset_prok
synonym: "10-formyl-THF biosynthesis" EXACT []
synonym: "10-formyl-THF biosynthetic process" EXACT []
synonym: "10-formyltetrahydrofolate anabolism" EXACT []
synonym: "10-formyltetrahydrofolate biosynthesis" EXACT []
synonym: "10-formyltetrahydrofolate formation" EXACT []
synonym: "10-formyltetrahydrofolate synthesis" EXACT []
xref: MetaCyc:1CMET2-PWY
xref: MetaCyc:PWY-3841
is_a: GO:0009256 ! 10-formyltetrahydrofolate metabolic process
is_a: GO:0043650 ! dicarboxylic acid biosynthetic process
is_a: GO:0046654 ! tetrahydrofolate biosynthetic process

[Term]
id: GO:0009258
name: 10-formyltetrahydrofolate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate." [GOC:ai]
subset: gosubset_prok
synonym: "10-formyl-THF catabolic process" EXACT []
synonym: "10-formyl-THF catabolism" EXACT []
synonym: "10-formyltetrahydrofolate breakdown" EXACT []
synonym: "10-formyltetrahydrofolate catabolism" EXACT []
synonym: "10-formyltetrahydrofolate degradation" EXACT []
is_a: GO:0009256 ! 10-formyltetrahydrofolate metabolic process
is_a: GO:0009397 ! folic acid-containing compound catabolic process
is_a: GO:0043649 ! dicarboxylic acid catabolic process

[Term]
id: GO:0009259
name: ribonucleotide metabolic process
namespace: biological_process
alt_id: GO:0009121
def: "The chemical reactions and pathways involving a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "ribonucleotide metabolism" EXACT []
is_a: GO:0009117 ! nucleotide metabolic process
is_a: GO:0019693 ! ribose phosphate metabolic process

[Term]
id: GO:0009260
name: ribonucleotide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "ribonucleotide anabolism" EXACT []
synonym: "ribonucleotide biosynthesis" EXACT []
synonym: "ribonucleotide formation" EXACT []
synonym: "ribonucleotide synthesis" EXACT []
is_a: GO:0009165 ! nucleotide biosynthetic process
is_a: GO:0009259 ! ribonucleotide metabolic process
is_a: GO:0046390 ! ribose phosphate biosynthetic process

[Term]
id: GO:0009261
name: ribonucleotide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "ribonucleotide breakdown" EXACT []
synonym: "ribonucleotide catabolism" EXACT []
synonym: "ribonucleotide degradation" EXACT []
is_a: GO:0009166 ! nucleotide catabolic process
is_a: GO:0009259 ! ribonucleotide metabolic process
is_a: GO:1901136 ! carbohydrate derivative catabolic process

[Term]
id: GO:0009262
name: deoxyribonucleotide metabolic process
namespace: biological_process
alt_id: GO:0009122
alt_id: GO:0009393
def: "The chemical reactions and pathways involving a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "deoxyribonucleotide metabolism" EXACT []
is_a: GO:0009117 ! nucleotide metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:0009263
name: deoxyribonucleotide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "deoxyribonucleotide anabolism" EXACT []
synonym: "deoxyribonucleotide biosynthesis" EXACT []
synonym: "deoxyribonucleotide formation" EXACT []
synonym: "deoxyribonucleotide synthesis" EXACT []
is_a: GO:0009165 ! nucleotide biosynthetic process
is_a: GO:0009262 ! deoxyribonucleotide metabolic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process

[Term]
id: GO:0009264
name: deoxyribonucleotide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "deoxyribonucleotide breakdown" EXACT []
synonym: "deoxyribonucleotide catabolism" EXACT []
synonym: "deoxyribonucleotide degradation" EXACT []
is_a: GO:0009166 ! nucleotide catabolic process
is_a: GO:0009262 ! deoxyribonucleotide metabolic process
is_a: GO:1901136 ! carbohydrate derivative catabolic process

[Term]
id: GO:0009265
name: 2'-deoxyribonucleotide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a 2'-deoxyribonucleotide, a compound consisting of 2'-deoxyribonucleoside (a base linked to a 2'-deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:mah]
subset: gosubset_prok
synonym: "2'-deoxyribonucleotide anabolism" EXACT []
synonym: "2'-deoxyribonucleotide biosynthesis" EXACT []
synonym: "2'-deoxyribonucleotide formation" EXACT []
synonym: "2'-deoxyribonucleotide synthesis" EXACT []
is_a: GO:0009263 ! deoxyribonucleotide biosynthetic process
is_a: GO:0009394 ! 2'-deoxyribonucleotide metabolic process
is_a: GO:0046385 ! deoxyribose phosphate biosynthetic process

[Term]
id: GO:0009266
name: response to temperature stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus." [GOC:hb]
subset: gosubset_prok
synonym: "response to thermal stimulus" EXACT []
is_a: GO:0009628 ! response to abiotic stimulus

[Term]
id: GO:0009267
name: cellular response to starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl]
subset: gosubset_prok
is_a: GO:0031669 ! cellular response to nutrient levels
is_a: GO:0033554 ! cellular response to stress
is_a: GO:0042594 ! response to starvation

[Term]
id: GO:0009268
name: response to pH
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution." [GOC:jl, http://en.wikipedia.org/wiki/PH]
subset: gosubset_prok
is_a: GO:0009628 ! response to abiotic stimulus

[Term]
id: GO:0009269
name: response to desiccation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desiccation stimulus, extreme dryness resulting from the prolonged deprivation of water." [GOC:jl]
subset: gosubset_prok
synonym: "desiccation tolerance" RELATED []
is_a: GO:0009414 ! response to water deprivation

[Term]
id: GO:0009270
name: response to humidity
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a humidity stimulus, moisture in the atmosphere." [GOC:jl]
is_a: GO:0009415 ! response to water

[Term]
id: GO:0009271
name: phage shock
namespace: biological_process
def: "A response by bacterial cells to a variety of stresses including filamentous phage infection, mislocalization of envelope proteins, extremes of temperature, osmolarity or ethanol concentration, and the presence of proton ionophores such as carbonylcyanide m-chlorophenylhydrazone (CCCP), that involves expression of the phage shock protein operon, and acts to protect the bacterial cells from damage." [GOC:add, GOC:jl, PMID:15485810, PMID:16045608]
subset: gosubset_prok
is_a: GO:0006950 ! response to stress
is_a: GO:0098586 ! cellular response to virus

[Term]
id: GO:0009272
name: fungal-type cell wall biogenesis
namespace: biological_process
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a fungal-type cell wall. The fungal-type cell wall contains beta-glucan and may contain chitin." [GOC:go_curators, GOC:mtg_sensu]
synonym: "chitin- and beta-glucan-containing cell wall biogenesis" NARROW [GOC:mah]
synonym: "fungal-type cell wall anabolism" RELATED [GOC:mah]
synonym: "fungal-type cell wall biosynthetic process" RELATED [GOC:mah]
synonym: "fungal-type cell wall formation" RELATED [GOC:mah]
synonym: "fungal-type cell wall synthesis" RELATED [GOC:mah]
is_a: GO:0042546 ! cell wall biogenesis
is_a: GO:0071852 ! fungal-type cell wall organization or biogenesis

[Term]
id: GO:0009273
name: peptidoglycan-based cell wall biogenesis
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the peptidoglycan-based cell wall. An example of this process is found in Escherichia coli." [GOC:go_curators]
subset: gosubset_prok
synonym: "cell envelope biosynthesis" BROAD []
synonym: "cell envelope biosynthetic process" BROAD []
synonym: "cell wall anabolism" BROAD []
synonym: "cell wall assembly" BROAD []
synonym: "cell wall biosynthetic process" BROAD []
synonym: "cell wall formation" BROAD []
synonym: "cell wall synthesis" BROAD []
is_a: GO:0042546 ! cell wall biogenesis

[Term]
id: GO:0009274
name: peptidoglycan-based cell wall
namespace: cellular_component
def: "A protective structure outside the cytoplasmic membrane composed of peptidoglycan (also known as murein), a molecule made up of a glycan (sugar) backbone of repetitively alternating N-acetylglucosamine and N-acetylmuramic acid with short, attached, cross-linked peptide chains containing unusual amino acids. An example of this component is found in Escherichia coli." [GOC:mlg, ISBN:0815108893]
subset: gosubset_prok
synonym: "envelope" BROAD []
synonym: "murein sacculus" RELATED []
synonym: "peptidoglycan" NARROW []
is_a: GO:0005618 ! cell wall

[Term]
id: GO:0009275
name: Gram-positive-bacterium-type cell wall
namespace: cellular_component
def: "A layer of peptidoglycan found outside of the cytoplasmic membrane. The peptidoglycan is relatively thick (20-80nm) and retains the primary stain of the Gram procedure, thus cells appear blue after Gram stain. The cell walls often contain teichoic acids (acidic anionic polysaccharides) bound to the peptidoglycan. Examples of this component are found in Gram-positive bacteria." [GOC:mlg, ISBN:0051406910, ISBN:0815108893]
subset: gosubset_prok
synonym: "20-80nm peptidoglycan-based cell wall" EXACT []
synonym: "cell wall of Gram-positive Bacteria" EXACT []
is_a: GO:0009274 ! peptidoglycan-based cell wall

[Term]
id: GO:0009276
name: Gram-negative-bacterium-type cell wall
namespace: cellular_component
def: "The peptidoglycan layer of the Gram-negative cell envelope. In Gram-negative cells the peptidoglycan is relatively thin (1-2nm) and is linked to the outer membrane by lipoproteins. In Gram-negative cells the peptidoglycan is too thin to retain the primary stain in the Gram staining procedure and therefore cells appear red after Gram stain." [GOC:mlg, ISBN:0815108893]
subset: gosubset_prok
synonym: "1-2nm peptidoglycan-based cell wall" EXACT []
synonym: "cell wall inner membrane" EXACT []
is_a: GO:0009274 ! peptidoglycan-based cell wall
relationship: part_of GO:0030313 ! cell envelope

[Term]
id: GO:0009277
name: fungal-type cell wall
namespace: cellular_component
def: "A rigid yet dynamic structure surrounding the plasma membrane that affords protection from stresses and contributes to cell morphogenesis, consisting of extensively cross-linked glycoproteins and carbohydrates. The glycoproteins may be modified with N- or O-linked carbohydrates, or glycosylphosphatidylinositol (GPI) anchors; the polysaccharides are primarily branched glucans, including beta-linked and alpha-linked glucans, and may also include chitin and other carbohydrate polymers, but not cellulose or pectin. Enzymes involved in cell wall biosynthesis are also found in the cell wall. Note that some forms of fungi develop a capsule outside of the cell wall under certain circumstances; this is considered a separate structure." [GOC:mcc, GOC:mtg_sensu, ISBN:3540601864, PMID:11283274, PMID:16927300, PMID:3319422]
synonym: "beta-glucan-containing cell wall" RELATED []
synonym: "chitin- and beta-glucan-containing cell wall" NARROW []
synonym: "chitin-containing cell wall" RELATED []
is_a: GO:0005618 ! cell wall

[Term]
id: GO:0009278
name: obsolete murein sacculus
namespace: cellular_component
def: "OBSOLETE. A peptidoglycan polymer that forms the shape-determining structure of the cell all of Gram-negative bacteria." [GOC:ma]
comment: This term was made obsolete because it was defined inaccurately.
synonym: "murein sacculus" EXACT []
is_obsolete: true
consider: GO:0009276

[Term]
id: GO:0009279
name: cell outer membrane
namespace: cellular_component
def: "A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures." [GOC:md, GOC:mtg_sensu, ISBN:0135712254]
comment: To annotate the plasma (cytoplasmic) membrane, see instead GO:0005886.
subset: gosubset_prok
synonym: "outer membrane of cell" EXACT []
is_a: GO:0019867 ! outer membrane
is_a: GO:0044462 ! external encapsulating structure part
intersection_of: GO:0019867 ! outer membrane
intersection_of: part_of GO:0030313 ! cell envelope
relationship: part_of GO:0030313 ! cell envelope

[Term]
id: GO:0009280
name: obsolete cell wall inner membrane
namespace: cellular_component
def: "OBSOLETE. In Gram-negative bacteria the membrane that separates the cytoplasm from the murein sacculus." [GOC:ma]
comment: This term was made obsolete because it was defined inaccurately.
synonym: "cell wall inner membrane" EXACT []
synonym: "cytoplasmic membrane" BROAD []
is_obsolete: true
consider: GO:0009276

[Term]
id: GO:0009288
name: bacterial-type flagellum
namespace: cellular_component
def: "A motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope." [GOC:cilia, GOC:jh2, GOC:krc, GOC:mtg_sensu, http:en.wikipedia.org/wiki/Flagellum#Bacterial, PMID:7787060]
subset: gosubset_prok
synonym: "flagellin-based flagellum" EXACT []
is_a: GO:0042995 ! cell projection
is_a: GO:0043228 ! non-membrane-bounded organelle

[Term]
id: GO:0009289
name: pilus
namespace: cellular_component
def: "A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter." [GOC:pamgo_curators]
subset: goslim_metagenomics
subset: goslim_pir
subset: gosubset_prok
synonym: "fimbria" EXACT []
synonym: "fimbriae" EXACT []
synonym: "fimbrium" EXACT []
synonym: "pili" EXACT []
xref: Wikipedia:Pilus
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0009290
name: DNA import into cell involved in transformation
namespace: biological_process
def: "The directed movement of DNA into a cell that contributes to the process of transformation, the uptake of foreign genetic material into a cell." [GOC:ai]
subset: gosubset_prok
synonym: "cellular DNA import during transformation" RELATED []
synonym: "cellular DNA uptake" BROAD []
synonym: "DNA import into cell" BROAD []
synonym: "DNA import into cell involved in transformation" RELATED [GOC:dph, GOC:tb]
synonym: "DNA transport into cell during transformation" RELATED []
is_a: GO:0044765 ! single-organism transport
is_a: GO:0051027 ! DNA transport
is_a: GO:0098657 ! import into cell
relationship: part_of GO:0009294 ! DNA mediated transformation

[Term]
id: GO:0009291
name: unidirectional conjugation
namespace: biological_process
def: "The process of unidirectional (polarized) transfer of genetic information involving direct cellular contact between a donor and recipient cell; the contact is followed by the formation of a cellular bridge that physically connects the cells; some or all of the chromosome(s) of one cell ('male') is then transferred into the other cell ('female'); unidirectional conjugation occurs between cells of different mating types. Examples of this process are found in Prokaryotes." [ISBN:0387520546]
subset: gosubset_prok
synonym: "mating" BROAD []
is_a: GO:0000746 ! conjugation
is_a: GO:0009292 ! genetic transfer

[Term]
id: GO:0009292
name: genetic transfer
namespace: biological_process
def: "In the absence of a sexual life cycle, the process involved in the introduction of genetic information to create a genetically different individual." [GOC:clt]
comment: GO:0009292 should not be used for annotation of phage lysogeny (integration of the bacteriophage nucleic acid into the host bacterium's genome).
subset: goslim_pir
subset: gosubset_prok
synonym: "genetic exchange" BROAD []
is_a: GO:0044764 ! multi-organism cellular process

[Term]
id: GO:0009293
name: transduction
namespace: biological_process
def: "The transfer of genetic information to a bacterium from a bacteriophage or between bacterial or yeast cells mediated by a phage vector." [ISBN:0198506732]
subset: gosubset_prok
xref: Wikipedia:Transduction_(genetics)
is_a: GO:0009292 ! genetic transfer

[Term]
id: GO:0009294
name: DNA mediated transformation
namespace: biological_process
def: "The introduction and uptake of foreign genetic material (DNA or RNA) into a cell, and often the expression of that genetic material." [ISBN:0716720094, Wikipedia:Transformation_(genetics)]
subset: gosubset_prok
synonym: "DNA-mediated transformation" EXACT []
is_a: GO:0009292 ! genetic transfer

[Term]
id: GO:0009295
name: nucleoid
namespace: cellular_component
def: "The region of a virus, bacterial cell, mitochondrion or chloroplast to which the nucleic acid is confined." [GOC:bm, GOC:ma, ISBN:3540076689]
subset: goslim_metagenomics
subset: gosubset_prok
xref: Wikipedia:Nucleoid
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0009296
name: obsolete flagellum assembly
namespace: biological_process
def: "The assembly of a flagellum. In bacteria, this is a whiplike motility appendage present on the surface of some species; in eukaryotes, flagella are threadlike protoplasmic extensions used to propel flagellates and sperm. Flagella are composed of flagellin and have the same basic structure as cilia but are longer in proportion to the cell and present in much smaller numbers." [GOC:curators, ISBN:0815316194]
subset: gosubset_prok
synonym: "flagella assembly" EXACT [GOC:mah]
synonym: "flagella biogenesis" RELATED []
synonym: "flagellum assembly" EXACT []
synonym: "flagellum biogenesis" RELATED [GOC:mah]
is_obsolete: true
consider: GO:0042384
consider: GO:0044780

[Term]
id: GO:0009297
name: pilus assembly
namespace: biological_process
def: "The assembly of a pilus, a short filamentous structure on a bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles." [GOC:dgh, GOC:mcc2, GOC:tb]
subset: gosubset_prok
synonym: "fimbria assembly" NARROW []
synonym: "fimbria biogenesis" RELATED []
synonym: "fimbriae assembly" NARROW []
synonym: "fimbriae biogenesis" RELATED []
synonym: "fimbrial assembly" NARROW []
synonym: "fimbrial biogenesis" NARROW []
synonym: "fimbrium assembly" NARROW []
synonym: "fimbrium biogenesis" RELATED []
synonym: "pili biosynthesis" EXACT []
synonym: "pili biosynthetic process" EXACT []
synonym: "pilus biogenesis" RELATED []
synonym: "pilus biosynthesis" EXACT []
synonym: "pilus formation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0030031 ! cell projection assembly
is_a: GO:0043711 ! pilus organization

[Term]
id: GO:0009298
name: GDP-mannose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "GDP-mannose anabolism" EXACT []
synonym: "GDP-mannose biosynthesis" EXACT []
synonym: "GDP-mannose formation" EXACT []
synonym: "GDP-mannose synthesis" EXACT []
is_a: GO:0009226 ! nucleotide-sugar biosynthetic process
is_a: GO:0019673 ! GDP-mannose metabolic process
relationship: has_part GO:0004615 ! phosphomannomutase activity

[Term]
id: GO:0009299
name: mRNA transcription
namespace: biological_process
alt_id: GO:0061023
def: "The cellular synthesis of messenger RNA (mRNA) from a DNA template." [GOC:jl]
subset: gosubset_prok
synonym: "cellular mRNA transcription" EXACT []
synonym: "mRNA biosynthesis" BROAD []
synonym: "mRNA biosynthetic process" BROAD []
synonym: "mRNA synthesis" BROAD []
is_a: GO:0006351 ! transcription, DNA-templated

[Term]
id: GO:0009300
name: antisense RNA transcription
namespace: biological_process
def: "The synthesis of antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis, on a template of DNA." [GOC:jl]
subset: gosubset_prok
is_a: GO:0006351 ! transcription, DNA-templated
is_a: GO:0042868 ! antisense RNA metabolic process

[Term]
id: GO:0009301
name: snRNA transcription
namespace: biological_process
def: "The synthesis of small nuclear RNA (snRNA) from a DNA template." [GOC:jl, ISBN:0321000382]
is_a: GO:0016073 ! snRNA metabolic process
is_a: GO:0098781 ! ncRNA transcription

[Term]
id: GO:0009302
name: snoRNA transcription
namespace: biological_process
def: "The synthesis of small nucleolar RNA (snoRNA) from a DNA template." [GOC:jl]
is_a: GO:0016074 ! snoRNA metabolic process
is_a: GO:0098781 ! ncRNA transcription

[Term]
id: GO:0009303
name: rRNA transcription
namespace: biological_process
def: "The synthesis of ribosomal RNA (rRNA), any RNA that forms part of the ribosomal structure, from a DNA template." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "rRNA biosynthesis" BROAD []
synonym: "rRNA biosynthetic process" BROAD []
synonym: "rRNA synthesis" BROAD []
is_a: GO:0098781 ! ncRNA transcription

[Term]
id: GO:0009304
name: tRNA transcription
namespace: biological_process
def: "The synthesis of transfer RNA (tRNA) from a DNA template." [GOC:jl]
subset: gosubset_prok
synonym: "tRNA biosynthesis" BROAD []
synonym: "tRNA biosynthetic process" BROAD []
synonym: "tRNA synthesis" BROAD []
is_a: GO:0006399 ! tRNA metabolic process
is_a: GO:0098781 ! ncRNA transcription

[Term]
id: GO:0009305
name: protein biotinylation
namespace: biological_process
def: "The addition of biotin (vitamin B7 / vitamin H) to a protein amino acid." [GOC:ai]
subset: gosubset_prok
synonym: "protein amino acid biotinylation" EXACT [GOC:bf]
is_a: GO:0006464 ! cellular protein modification process

[Term]
id: GO:0009306
name: protein secretion
namespace: biological_process
alt_id: GO:0045166
alt_id: GO:0045731
def: "The controlled release of proteins from a cell." [GOC:ai]
subset: goslim_metagenomics
subset: gosubset_prok
synonym: "glycoprotein secretion" NARROW []
synonym: "protein secretion during cell fate commitment" NARROW []
synonym: "protein secretion resulting in cell fate commitment" NARROW []
is_a: GO:0015031 ! protein transport
is_a: GO:0032940 ! secretion by cell

[Term]
id: GO:0009307
name: DNA restriction-modification system
namespace: biological_process
def: "A defense process found in many bacteria and archaea that protects the organism from invading foreign DNA by cleaving it with a restriction endonuclease. The organism's own DNA is protected by methylation of a specific nucleotide, which occurs immediately following replication, in the same target site as the restriction enzyme." [GOC:jl, UniProtKB-KW:KW-0680]
subset: gosubset_prok
synonym: "DNA restriction" BROAD []
is_a: GO:0006304 ! DNA modification
is_a: GO:0044355 ! clearance of foreign intracellular DNA

[Term]
id: GO:0009308
name: amine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl, ISBN:0198506732]
subset: goslim_chembl
subset: goslim_pir
subset: gosubset_prok
synonym: "amine metabolism" EXACT []
is_a: GO:1901564 ! organonitrogen compound metabolic process

[Term]
id: GO:0009309
name: amine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "amine anabolism" EXACT []
synonym: "amine biosynthesis" EXACT []
synonym: "amine formation" EXACT []
synonym: "amine synthesis" EXACT []
is_a: GO:0009308 ! amine metabolic process
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process

[Term]
id: GO:0009310
name: amine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "amine breakdown" EXACT []
synonym: "amine catabolism" EXACT []
synonym: "amine degradation" EXACT []
is_a: GO:0009308 ! amine metabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process

[Term]
id: GO:0009311
name: oligosaccharide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732]
subset: goslim_yeast
subset: gosubset_prok
synonym: "oligosaccharide metabolism" EXACT []
is_a: GO:0044723 ! single-organism carbohydrate metabolic process

[Term]
id: GO:0009312
name: oligosaccharide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732]
subset: gosubset_prok
synonym: "oligosaccharide anabolism" EXACT []
synonym: "oligosaccharide biosynthesis" EXACT []
synonym: "oligosaccharide formation" EXACT []
synonym: "oligosaccharide synthesis" EXACT []
is_a: GO:0009311 ! oligosaccharide metabolic process
is_a: GO:0016051 ! carbohydrate biosynthetic process

[Term]
id: GO:0009313
name: oligosaccharide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732]
subset: gosubset_prok
synonym: "oligosaccharide breakdown" EXACT []
synonym: "oligosaccharide catabolism" EXACT []
synonym: "oligosaccharide degradation" EXACT []
is_a: GO:0009311 ! oligosaccharide metabolic process
is_a: GO:0044724 ! single-organism carbohydrate catabolic process

[Term]
id: GO:0009314
name: response to radiation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation." [GOC:jl, Wikipedia:Electromagnetic_radiation]
comment: Note that 'radiation' refers to electromagnetic radiation of any wavelength.
subset: gosubset_prok
synonym: "response to electromagnetic radiation stimulus" EXACT []
synonym: "response to radiation stimulus" EXACT []
is_a: GO:0009628 ! response to abiotic stimulus

[Term]
id: GO:0009315
name: obsolete drug resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process.
synonym: "drug resistance" EXACT []
is_obsolete: true
replaced_by: GO:0042493

[Term]
id: GO:0009316
name: 3-isopropylmalate dehydratase complex
namespace: cellular_component
def: "A heterodimeric enzyme complex composed of subunits leuC and leuD. Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate." [BRENDA:4.2.1.33, GOC:jl, MetaCyc:3-ISOPROPYLMALISOM-CPLX, PMID:7026530]
comment: See also the molecular function term '3-isopropylmalate dehydratase activity ; GO:0003861'.
subset: gosubset_prok
synonym: "isopropylmalate isomerase complex" EXACT []
xref: MetaCyc:3-ISOPROPYLMALISOM-CPLX
is_a: GO:0044445 ! cytosolic part
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0009317
name: acetyl-CoA carboxylase complex
namespace: cellular_component
def: "A protein complex that catalyzes the first step in long-chain fatty acid biosynthesis. For example, in E. coli the complex is heterohexameric and composed of biotin carbonyl carrier protein, biotin carboxylase and the acetate CoA-transferase complex." [GOC:jl, GOC:mah, PMID:12121720]
subset: goslim_pir
subset: gosubset_prok
synonym: "ACCase complex" EXACT []
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0009318
name: exodeoxyribonuclease VII complex
namespace: cellular_component
def: "An enzyme complex that catalyzes exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield nucleoside 5'-phosphates; it prefers single-stranded DNA." [EC:3.1.11.6]
subset: gosubset_prok
is_a: GO:0044424 ! intracellular part
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0009319
name: cytochrome o ubiquinol oxidase complex
namespace: cellular_component
def: "A protein complex that possesses cytochrome o ubiquinol oxidase activity; consists of four polypeptide subunits and associated prosthetic groups." [GOC:mah, MetaCyc:CYT-O-UBIOX-CPLX, PMID:11017202, PMID:3052268]
comment: See also the molecular function term 'cytochrome o ubiquinol oxidase activity ; GO:0008827'.
subset: gosubset_prok
xref: MetaCyc:CYT-O-UBIOX-CPLX
is_a: GO:0070069 ! cytochrome complex
is_a: GO:0098796 ! membrane protein complex
is_a: GO:1990204 ! oxidoreductase complex
relationship: part_of GO:0016021 ! integral component of membrane

[Term]
id: GO:0009320
name: phosphoribosylaminoimidazole carboxylase complex
namespace: cellular_component
def: "A protein complex that possesses phosphoribosylaminoimidazole carboxylase activity." [GOC:mah]
comment: See also the molecular function term 'phosphoribosylaminoimidazole carboxylase activity ; GO:0004638'.
subset: gosubset_prok
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0009321
name: alkyl hydroperoxide reductase complex
namespace: cellular_component
def: "An enzyme complex, usually a homodimer, which directly reduces cellular levels of organic hydroperoxides." [BRENDA:1.11.1.15, GOC:jl, PMID:2649484]
comment: See also the molecular function term 'alkyl hydroperoxide reductase activity ; GO:0008785'.
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:0009322
name: trimethylamine-N-oxide reductase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the reduction of trimethylamine N-oxide to trimethylamine." [EC:1.6.6.9]
subset: gosubset_prok
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:0009323
name: ribosomal-protein-alanine N-acetyltransferase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the transfer of an acetyl group to ribosomal-protein alanine, forming ribosomal-protein acetylalanine." [EC:2.3.1.128]
is_a: GO:0031248 ! protein acetyltransferase complex

[Term]
id: GO:0009324
name: D-amino-acid dehydrogenase complex
namespace: cellular_component
def: "A protein complex that possesses D-amino-acid dehydrogenase activity." [GOC:mah]
comment: See also the molecular function term 'D-amino-acid oxidase activity ; GO:0003884'.
subset: gosubset_prok
is_a: GO:0098797 ! plasma membrane protein complex
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:0009325
name: nitrate reductase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the formation of nitrate from nitrite with the concomitant reduction of an acceptor." [EC:1.7.99.4]
subset: gosubset_prok
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:0009326
name: formate dehydrogenase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the dehydrogenation of formate to produce carbon dioxide (CO2)." [EC:1.2.1.2]
subset: gosubset_prok
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:0009327
name: NAD(P)+ transhydrogenase complex (AB-specific)
namespace: cellular_component
def: "A protein complex that possesses NAD(P)+ transhydrogenase (AB-specific) activity. Homodimeric, trimeric, and heterotetrameric complexes have been identified." [BRENDA:1.6.1.2, GOC:mah]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0009328
name: phenylalanine-tRNA ligase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the ligation of phenylalanine to tRNA(Phe), forming L-phenylalanyl-tRNA(Phe)." [EC:6.1.1.20]
subset: gosubset_prok
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0009329
name: acetate CoA-transferase complex
namespace: cellular_component
def: "A heterotetrameric enzyme complex made up of two alpha subunits and two beta subunits. Part of the acetyl-CoA carboxylase complex. Catalyzes the transfer of a carboxyl group to form malonyl-CoA." [GOC:jl, PMID:2719476, PMID:8423010]
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:1990234 ! transferase complex
relationship: part_of GO:0009317 ! acetyl-CoA carboxylase complex

[Term]
id: GO:0009330
name: DNA topoisomerase complex (ATP-hydrolyzing)
namespace: cellular_component
def: "Complex that possesses DNA topoisomerase (ATP-hydrolyzing) activity." [GOC:mah]
comment: See also the molecular function term 'DNA topoisomerase (ATP-hydrolyzing) activity ; GO:0003918'.
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0009331
name: glycerol-3-phosphate dehydrogenase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate." [EC:1.1.5.3]
subset: gosubset_prok
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:0009332
name: glutamate-tRNA ligase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the ligation of glutamate and tRNA(Glu) to form glutamyl-tRNA(Glu)." [EC:6.1.1.17]
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0009333
name: cysteine synthase complex
namespace: cellular_component
def: "Cysteine synthase is a multienzyme complex made up, in E. coli, of the heteromeric hexamer serine acetyltransferase and the homodimer O-acetylserine (thiol)-lyase A." [EC:4.2.99.8, MetaCyc:CYSSYNMULTI-CPLX]
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0009334
name: 3-phenylpropionate dioxygenase complex
namespace: cellular_component
def: "Enzyme complex consisting of four proteins: the two subunits of the hydroxylase component (hcaE and hcaF), a ferredoxin (hcaC) and a ferredoxin reductase (hcaD). Converts 3-phenylpropionic acid (PP) into cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol (PP-dihydrodiol)." [GOC:jl, MetaCyc:HCAMULTI-CPLX, PMID:9603882]
comment: See also the molecular function term '3-phenylpropionate dioxygenase activity ; GO:0008695'.
xref: MetaCyc:HCAMULTI-CPLX
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:0009335
name: obsolete holo-[acyl-carrier protein] synthase complex
namespace: cellular_component
def: "OBSOLETE. An enzyme complex that catalyzes the formation of holo-[acyl-carrier protein] from CoA and apo-[acyl-carrier protein]." [EC:2.7.8.7]
comment: This term was made obsolete because the catalytic activity resides in a single polypeptide rather than a complex, and the complex is represented by a different GO term.
synonym: "holo-[acyl-carrier protein] synthase complex" EXACT []
synonym: "holo-ACP synthase complex" EXACT []
is_obsolete: true
consider: GO:0005835

[Term]
id: GO:0009336
name: sulfate adenylyltransferase complex (ATP)
namespace: cellular_component
def: "An enzyme complex that catalyzes the formation adenylylsulfate from sulfate and ATP." [EC:2.7.7.4]
synonym: "sulphate adenylyltransferase complex (ATP)" EXACT []
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:1902503 ! adenylyltransferase complex

[Term]
id: GO:0009337
name: sulfite reductase complex (NADPH)
namespace: cellular_component
def: "A multisubunit iron flavoprotein, which in yeast is composed of 2 alpha and 2 beta subunits. Catalyzes the reduction of sulfite to sulfide." [BRENDA:1.8.1.2, GOC:jl]
comment: See also the molecular function term 'sulfite reductase (NADPH) activity ; GO:0004783'.
subset: gosubset_prok
synonym: "sulphite reductase complex (NADPH)" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0009338
name: exodeoxyribonuclease V complex
namespace: cellular_component
def: "An enzyme complex that catalyzes exonucleolytic cleavage (in the presence of ATP) in either 5' to 3' or 3' to 5' direction to yield 5'-phosphooligonucleotides. Exodeoxyribonuclease V shows a preference for double-stranded DNA and possesses DNA-dependent ATPase activity. It acts endonucleolytically on single-stranded circular DNA." [EC:3.1.11.5]
subset: gosubset_prok
is_a: GO:0044424 ! intracellular part
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0009339
name: glycolate oxidase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the oxidation of 2-hydroxy acid to form 2-oxo acid and hydrogen peroxide (H2O2). The enzyme is a flavoprotein (FMN)." [EC:1.1.3.15]
subset: gosubset_prok
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:0009340
name: DNA topoisomerase IV complex
namespace: cellular_component
def: "A heterodimeric enzyme, which in most bacterial species is composed of two subunits, ParC and ParE. Functions in chromosome segregation and can relax supercoiled DNA." [GOC:jl, PMID:7783632]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0009341
name: beta-galactosidase complex
namespace: cellular_component
def: "A protein complex that possesses beta-galactosidase activity, i.e. catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides. In E. coli, the complex is a homotetramer; dimeric and hexameric beta-galactosidase complexes have been observed in other species." [BRENDA:3.2.1.2, EC:3.2.1.23, PMID:15950161]
subset: gosubset_prok
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0009342
name: glutamate synthase complex (NADPH)
namespace: cellular_component
def: "A complex that possesses glutamate synthase (NADPH) activity." [EC:1.4.1.13, GOC:mah]
subset: gosubset_prok
is_a: GO:0031026 ! glutamate synthase complex

[Term]
id: GO:0009343
name: biotin carboxylase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the formation of carboxybiotin-carboxyl-carrier protein from biotin-carboxyl-carrier protein and carbon dioxide (CO2)." [EC:6.3.4.14]
subset: gosubset_prok
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:1902494 ! catalytic complex
relationship: part_of GO:0009317 ! acetyl-CoA carboxylase complex

[Term]
id: GO:0009344
name: nitrite reductase complex [NAD(P)H]
namespace: cellular_component
def: "Complex that possesses nitrite reductase [NAD(P)H] activity." [GOC:mah]
comment: See also the molecular function term 'nitrite reductase [NAD(P)H] activity ; GO:0008942'.
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0009345
name: glycine-tRNA ligase complex
namespace: cellular_component
def: "A multimeric enzyme complex which, in bacteria, is usually a tetramer of two alpha and two beta chains and in eukaryotes, is usually a homodimer. Functions in the ligation of glycine and tRNA(Gly) to form glycyl-tRNA(Gly)." [EC:6.1.1.14, GOC:jl, PMID:15733854]
subset: gosubset_prok
synonym: "glycine-tRNA synthetase complex" EXACT []
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0009346
name: citrate lyase complex
namespace: cellular_component
def: "Citrate lyase is a multienzyme complex with three constituents: the alpha subunit, citrate-ACP transferase; the beta subunit, citryl-ACP lyase; and the gamma subunit, an acyl-carrier protein which also carries the prosthetic group components. All three subunits are required for citrate lyase enzyme activity." [EC:4.1.3.6, MetaCyc:ACECITLY-CPLX]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0009347
name: aspartate carbamoyltransferase complex
namespace: cellular_component
def: "A multienzyme complex that catalyzes the formation N-carbamoyl-L-aspartate from carbamoyl phosphate and L-aspartate. It exhibits a variety of architectural organizations, but in all microorganisms the core catalytic component is a homotrimer of approximately 34 kDa polypeptides." [PMID:10447693]
comment: Note that in eukaryotes, aspartate carbamoyltransferase is usually a single polypeptide, not a complex, and should therefore not be annotated to this component term.
subset: gosubset_prok
is_a: GO:0044464 ! cell part
is_a: GO:1990234 ! transferase complex

[Term]
id: GO:0009348
name: ornithine carbamoyltransferase complex
namespace: cellular_component
def: "A homotrimeric protein complex that catalyzes the transfer of a carbamoyl group to ornithine, forming citrulline." [EC:2.1.3.3, GOC:mah]
subset: gosubset_prok
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:1990234 ! transferase complex

[Term]
id: GO:0009349
name: riboflavin synthase complex
namespace: cellular_component
def: "An flavoprotein that catalyzes the reaction the breakdown of dimethyl(ribityl)lumazine to form riboflavin and ribitylamino-amino-dihydroxypyrimidine." [EC:2.5.1.9]
subset: gosubset_prok
is_a: GO:0044464 ! cell part
is_a: GO:1990234 ! transferase complex

[Term]
id: GO:0009350
name: ethanolamine ammonia-lyase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the breakdown of ethanolamine to form acetaldehyde and ammonia." [EC:4.3.1.7]
is_a: GO:0044424 ! intracellular part
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0009351
name: obsolete dihydrolipoamide S-acyltransferase complex
namespace: cellular_component
def: "OBSOLETE. An enzyme complex that catalyzes the transfer of an acyl group from coenzyme A to dihydrolipoamide." [EC:2.3.1.12]
comment: This term was made obsolete because dihydrolipoamide S-acyltransferase activity resides in a single polypeptide.
synonym: "dihydrolipoamide S-acyltransferase complex" EXACT []
is_obsolete: true

[Term]
id: GO:0009352
name: obsolete dihydrolipoyl dehydrogenase complex
namespace: cellular_component
def: "OBSOLETE. Complex that possesses dihydrolipoyl dehydrogenase activity." [GOC:mah]
comment: This term was made obsolete because the activity dihydrolipoamide dehydrogenase is held by a single protein (Lpd1 in yeast), which is one of the components of three different complexes: 2-oxoglutarate dehydrogenase, pyruvate dehydrogenase, and branch chain amino acid dehydrogenase, so dihydrolipoamide dehydrogenase is not a complex itself.
synonym: "dihydrolipoamide dehydrogenase complex" EXACT []
synonym: "dihydrolipoyl dehydrogenase complex" EXACT []
is_obsolete: true
consider: GO:0004148
consider: GO:0045240
consider: GO:0045254

[Term]
id: GO:0009353
name: mitochondrial oxoglutarate dehydrogenase complex
namespace: cellular_component
def: "A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2) within the mitochondrial matrix. An example of this complex is found in Mus musculus." [GOC:mtg_sensu, MetaCyc:CPLX66-42, PMID:10848975]
comment: See also the molecular functions term 'oxoglutarate dehydrogenase (succinyl-transferring) activity ; GO:0004591', 'dihydrolipoyllysine-residue succinyltransferase activity ; GO:0004149' and 'dihydrolipoyl dehydrogenase activity ; GO:0004148'.
is_a: GO:0005947 ! mitochondrial alpha-ketoglutarate dehydrogenase complex
is_a: GO:0045252 ! oxoglutarate dehydrogenase complex
intersection_of: GO:0045252 ! oxoglutarate dehydrogenase complex
intersection_of: part_of GO:0005739 ! mitochondrion
relationship: part_of GO:0005739 ! mitochondrion
relationship: part_of GO:0005759 ! mitochondrial matrix

[Term]
id: GO:0009354
name: obsolete dihydrolipoamide S-succinyltransferase complex
namespace: cellular_component
def: "OBSOLETE. An enzyme complex that catalyzes the transfer of succinyl-CoA to dihydrolipoamide to form S-succinyldihydrolipoamide. The enzyme is a component of the multienzyme 2-oxoglutarate dehydrogenase complex." [EC:2.3.1.61]
comment: This term was made obsolete because dihydrolipoamide S-succinyltransferase itself is not a complex, it is a component of the 2-oxoglutarate dehydrogenase complex, the activity dihydrolipoamide S-succinyltransferase is contained in a single polypeptide.
synonym: "dihydrolipoamide S-succinyltransferase complex" EXACT []
is_obsolete: true
consider: GO:0045252

[Term]
id: GO:0009355
name: DNA polymerase V complex
namespace: cellular_component
def: "A DNA polymerase complex that contains two UmuD' and one UmuC subunits, and acts in translesion DNA synthesis." [PMID:10430871, PMID:10542196]
is_a: GO:0042575 ! DNA polymerase complex

[Term]
id: GO:0009356
name: aminodeoxychorismate synthase complex
namespace: cellular_component
def: "A heterodimeric protein complex that possesses 4-amino-4-deoxychorismate synthase activity." [PMID:2251281, PMID:7592344]
synonym: "4-amino-4-deoxychorismate synthase complex" RELATED []
synonym: "ADC synthase complex" EXACT []
synonym: "p-aminobenzoate synthetase complex" RELATED []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0009357
name: protein-N(PI)-phosphohistidine-sugar phosphotransferase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the transfer of a phosphate from protein N(PI)-phosphohistidine to a sugar molecule. It is enzyme II of the phosphotransferase system." [EC:2.7.1.69]
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups
is_a: GO:1902495 ! transmembrane transporter complex

[Term]
id: GO:0009358
name: polyphosphate kinase complex
namespace: cellular_component
def: "A protein complex that possesses polyphosphate kinase activity." [GOC:mah]
comment: See also the molecular function term 'polyphosphate kinase activity ; GO:0008976'.
subset: gosubset_prok
is_a: GO:0044464 ! cell part
is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups

[Term]
id: GO:0009359
name: Type II site-specific deoxyribonuclease complex
namespace: cellular_component
def: "A protein complex that functions as an endonuclease to cleave DNA at or near a specific recognition site, when that site is unmethylated. These complexes may be dimers or tetramers; it is also possible for the endonuclease to be in a complex with the corresponding methyltransferase that methylates the recognition site. DNA restriction systems such as this are used by bacteria to defend against phage and other foreign DNA that may enter a cell." [PMID:12654995]
subset: gosubset_prok
synonym: "Type II restriction enzyme complex" EXACT []
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0009360
name: DNA polymerase III complex
namespace: cellular_component
def: "The DNA polymerase III holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential sub-assemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core carries out the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork." [PMID:11525729, PMID:12940977, UniProt:P06710]
subset: gosubset_prok
synonym: "DNA polymerase III holoenzyme complex" EXACT []
is_a: GO:0042575 ! DNA polymerase complex

[Term]
id: GO:0009361
name: succinate-CoA ligase complex (ADP-forming)
namespace: cellular_component
def: "A heterodimeric enzyme complex, composed of an alpha and beta chain, most usually found in (but not limited to) bacteria. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP." [EC:6.2.1.5, GOC:jl]
subset: gosubset_prok
synonym: "succinyl-CoA synthetase, ADP-forming" EXACT [CORUM:394]
is_a: GO:0042709 ! succinate-CoA ligase complex

[Term]
id: GO:0009365
name: protein histidine kinase complex
namespace: cellular_component
def: "A complex that possesses protein histidine kinase activity." [GOC:mah]
is_a: GO:1902911 ! protein kinase complex

[Term]
id: GO:0009366
name: enterobactin synthetase complex
namespace: cellular_component
def: "A multienzyme complex usually composed of four proteins, EntB, EntD, EntE and EntF. Plays a role in the enterobactin biosynthesis pathway." [MetaCyc:ENTMULTI-CPLX, PMID:9485415]
subset: gosubset_prok
synonym: "enterochelin synthetase complex" EXACT []
xref: MetaCyc:ENTMULTI-CPLX
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0009367
name: obsolete prepilin peptidase complex
namespace: cellular_component
def: "OBSOLETE. An enzyme complex that catalyzes the cleavage of a Gly-Phe bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group." [EC:3.4.23.43]
comment: This term was made obsolete because prepilin peptidase is a single gene product, and there is no evidence that it acts as a multimer.
synonym: "prepilin peptidase complex" EXACT []
is_obsolete: true

[Term]
id: GO:0009368
name: endopeptidase Clp complex
namespace: cellular_component
def: "A protein complex comprised of members of the ClpX, ClpC, ClpD, ClpP or ClpR protein families. ClpPs are the proteolytic subunit of active complexes, and ClpA and ClpX form the regulatory subunits. Enzymatically active and inactive complexes can form." [GOC:mah, PMID:11352464]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0009371
name: positive regulation of transcription by pheromones
namespace: biological_process
def: "Any process involving pheromones that activates or increases the rate of transcription." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of transcription by pheromones" NARROW []
synonym: "stimulation of transcription by pheromones" NARROW []
synonym: "up regulation of transcription by pheromones" EXACT []
synonym: "up-regulation of transcription by pheromones" EXACT []
synonym: "upregulation of transcription by pheromones" EXACT []
is_a: GO:0009373 ! regulation of transcription by pheromones
is_a: GO:0045893 ! positive regulation of transcription, DNA-templated

[Term]
id: GO:0009372
name: quorum sensing
namespace: biological_process
def: "The process in which single-celled organisms monitor their population density by detecting the concentration of small, diffusible signal molecules produced by the cells themselves." [PMID:15716452, PMID:8288518]
subset: goslim_pir
subset: gosubset_prok
synonym: "quorum sensing system" EXACT []
xref: Wikipedia:Quorum_sensing
is_a: GO:0048874 ! homeostasis of number of cells in a free-living population

[Term]
id: GO:0009373
name: regulation of transcription by pheromones
namespace: biological_process
def: "Any process involving pheromones that modulates the frequency, rate or extent of transcription." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0006355 ! regulation of transcription, DNA-templated
relationship: part_of GO:0071444 ! cellular response to pheromone

[Term]
id: GO:0009374
name: biotin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with biotin (cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid), the (+) enantiomer of which is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "vitamin B7 binding" EXACT []
synonym: "vitamin H binding" EXACT []
is_a: GO:0019842 ! vitamin binding
is_a: GO:0033218 ! amide binding
is_a: GO:0033293 ! monocarboxylic acid binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding
is_a: GO:1901681 ! sulfur compound binding

[Term]
id: GO:0009375
name: ferredoxin hydrogenase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the oxidation of reduced ferredoxin. Hydrogenase contains iron-sulfur clusters, and some contain nickel; it can use molecular hydrogen for the reduction of a variety of substances." [EC:1.12.7.2]
subset: gosubset_prok
synonym: "hydrogenase complex" BROAD []
is_a: GO:0044424 ! intracellular part
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:0009376
name: HslUV protease complex
namespace: cellular_component
def: "A protein complex that possesses ATP-dependent protease activity; consists of an ATPase large subunit with homology to other ClpX family ATPases and a peptidase small subunit related to the proteasomal beta-subunits of eukaryotes. In the E. coli complex, a double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer." [GOC:bhm, PMID:12670962, UniProt:P0A6H5]
subset: gosubset_prok
synonym: "ClpYQ protease complex" EXACT []
is_a: GO:0031597 ! cytosolic proteasome complex

[Term]
id: GO:0009377
name: obsolete HslUV protease activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the ATP-dependent hydrolysis of peptide bonds in substrates including E. coli SulA and misfolded proteins." [GOC:mah, PMID:10368141]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "HslUV protease activity" EXACT []
is_obsolete: true
replaced_by: GO:0070011

[Term]
id: GO:0009378
name: four-way junction helicase activity
namespace: molecular_function
def: "Catalysis of the unwinding of the DNA helix of DNA containing four-way junctions, including Holliday junctions." [GOC:jl, PMID:9442895]
subset: gosubset_prok
synonym: "Holliday junction helicase activity" NARROW []
is_a: GO:0003678 ! DNA helicase activity

[Term]
id: GO:0009379
name: Holliday junction helicase complex
namespace: cellular_component
def: "A DNA helicase complex that forms part of a Holliday junction resolvase complex, where the helicase activity is involved in the migration of the junction branch point. The best-characterized example is the E. coli RuvAB complex, in which a hexamer of RuvB subunits possesses helicase activity that is modulated by association with RuvA." [PMID:16935884, PMID:9442895]
subset: gosubset_prok
is_a: GO:0033202 ! DNA helicase complex
intersection_of: GO:0033202 ! DNA helicase complex
intersection_of: part_of GO:0048476 ! Holliday junction resolvase complex
relationship: part_of GO:0048476 ! Holliday junction resolvase complex

[Term]
id: GO:0009380
name: excinuclease repair complex
namespace: cellular_component
def: "Any of the protein complexes formed by the UvrABC excinuclease system, which carries out nucleotide excision repair. Three different complexes are formed by the 3 proteins as they proceed through the excision repair process. First a complex consisting of two A subunits and two B subunits bind DNA and unwind it around the damaged site. Then, the A subunits disassociate leaving behind a stable complex between B subunits and DNA. Now, subunit C binds to this B+DNA complex and causes subunit B to nick the DNA on one side of the complex while subunit C nicks the DNA on the other side of the complex. DNA polymerase I and DNA ligase can then repair the resulting gap." [GOC:mah, GOC:mlg, PMID:12145219, PMID:15192705]
subset: gosubset_prok
synonym: "excinuclease ABC complex" EXACT []
synonym: "UvrABC excinuclease complex" EXACT []
is_a: GO:0044424 ! intracellular part
is_a: GO:1902494 ! catalytic complex
is_a: GO:1990391 ! DNA repair complex

[Term]
id: GO:0009381
name: excinuclease ABC activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid at sites flanking regions of damaged DNA to which the Uvr ABC excinuclease complexes bind." [GOC:mah, PMID:15192705]
subset: gosubset_prok
is_a: GO:0004520 ! endodeoxyribonuclease activity

[Term]
id: GO:0009382
name: imidazoleglycerol-phosphate synthase complex
namespace: cellular_component
def: "Complex that possesses imidazoleglycerol-phosphate synthase activity." [GOC:mah]
comment: See also the molecular function term 'imidazoleglycerol-phosphate synthase activity ; GO:0000107'.
subset: gosubset_prok
synonym: "imidazoleglycerol phosphate synthase complex" EXACT []
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:1990234 ! transferase complex

[Term]
id: GO:0009383
name: rRNA (cytosine-C5-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to cytosine to form 5-methylcytosine in small subunit ribosomal RNA." [GOC:imk, PMID:10026269, PMID:18786544]
synonym: "rRNA (cytosine-C5-967)-methyltransferase activity" NARROW []
synonym: "rRNA m5C967 methyltransferase activity" NARROW []
xref: EC:2.1.1.-
is_a: GO:0008169 ! C-methyltransferase activity
is_a: GO:0016434 ! rRNA (cytosine) methyltransferase activity

[Term]
id: GO:0009384
name: N-acylmannosamine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + N-acyl-D-mannosamine = ADP + N-acyl-D-mannosamine 6-phosphate." [EC:2.7.1.60]
subset: gosubset_prok
synonym: "acetylamidodeoxymannokinase activity" EXACT [EC:2.7.1.60]
synonym: "acetylmannosamine kinase activity" EXACT [EC:2.7.1.60]
synonym: "acylaminodeoxymannokinase activity" EXACT [EC:2.7.1.60]
synonym: "acylmannosamine kinase (phosphorylating)" EXACT [EC:2.7.1.60]
synonym: "acylmannosamine kinase activity" EXACT [EC:2.7.1.60]
synonym: "ATP:N-acetylmannosamine 6-phosphotransferase activity" EXACT [EC:2.7.1.60]
synonym: "ATP:N-acyl-D-mannosamine 6-phosphotransferase activity" EXACT [EC:2.7.1.60]
synonym: "N-acetylmannosamine kinase activity" EXACT [EC:2.7.1.60]
synonym: "N-acyl-D-mannosamine kinase activity" EXACT [EC:2.7.1.60]
xref: EC:2.7.1.60
xref: MetaCyc:N-ACYLMANNOSAMINE-KINASE-RXN
xref: RHEA:23835
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0009385
name: N-acylmannosamine-6-phosphate 2-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-D-mannosamine-6-phosphate = N-acetyl-D-glucosamine-6-phosphate." [MetaCyc:NANE-RXN]
synonym: "N-acylmannosamine-6-P epimerase activity" EXACT []
xref: EC:5.-.-.-
xref: MetaCyc:NANE-RXN
is_a: GO:0016853 ! isomerase activity

[Term]
id: GO:0009386
name: translational attenuation
namespace: biological_process
def: "Translational attenuation is a regulatory mechanism analogous to ribosome-mediated transcriptional attenuation. The system requires the presence of a short ORF, called a leader peptide, encoded in the mRNA upstream of the ribosome-binding site and start codon of the gene whose translation is to be regulated. Certain conditions, such as presence of the antibiotic tetracycline in bacteria or amino acid starvation, may cause slowing or stalling of the ribosome translating the leader peptide. The stalled ribosome masks a region of the mRNA and affects which of two alternative mRNA folded structures will form, therefore controlling whether or not a ribosome will bind and initiate translation of the downstream gene. Translational attenuation is analogous to ribosome-mediated transcriptional attenuation, in which mRNA remodeling caused by ribosome stalling regulates transcriptional termination rather than translational initiation." [PMID:15694341, PMID:15805513]
subset: gosubset_prok
is_a: GO:0006417 ! regulation of translation

[Term]
id: GO:0009388
name: obsolete antisense RNA
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "antisense RNA" EXACT []
is_obsolete: true

[Term]
id: GO:0009389
name: dimethyl sulfoxide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: dimethyl sulfoxide + H+ = dimethyl sulfide + H2O." [UM-BBD_reactionID:r0207]
subset: gosubset_prok
synonym: "dimethyl sulphoxide reductase activity" EXACT []
xref: EC:1.8.99.-
xref: UM-BBD_reactionID:r0207
is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors

[Term]
id: GO:0009390
name: dimethyl sulfoxide reductase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the formation of dimethyl sulfide from dimethyl sulfoxide." [UM-BBD_enzymeID:e0188]
synonym: "dimethyl sulphoxide reductase complex" EXACT []
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:0009392
name: N-acetyl-anhydromuramoyl-L-alanine amidase activity
namespace: molecular_function
def: "Catalysis of the reaction: GlcNAc-1,6-anhMurNAc-L-Ala-gamma-D-Glu-DAP-D-Ala + H2O glcNAc-1,6-anhMurNAc + L-Ala-gamma-D-Glu-DAP-D-Ala." [MetaCyc:RXN0-5225]
xref: MetaCyc:RXN0-5225
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

[Term]
id: GO:0009394
name: 2'-deoxyribonucleotide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a 2'-deoxyribonucleotide, a compound consisting of 2'-deoxyribonucleoside (a base linked to a 2'-deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:mah]
subset: gosubset_prok
synonym: "2'-deoxyribonucleotide metabolism" EXACT []
is_a: GO:0009262 ! deoxyribonucleotide metabolic process
is_a: GO:0019692 ! deoxyribose phosphate metabolic process

[Term]
id: GO:0009395
name: phospholipid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]
subset: gosubset_prok
synonym: "phospholipid breakdown" EXACT []
synonym: "phospholipid catabolism" EXACT []
synonym: "phospholipid degradation" EXACT []
is_a: GO:0006644 ! phospholipid metabolic process
is_a: GO:0044242 ! cellular lipid catabolic process
is_a: GO:0046434 ! organophosphate catabolic process

[Term]
id: GO:0009396
name: folic acid-containing compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of folic acid and its derivatives." [GOC:ai]
subset: gosubset_prok
synonym: "folate and derivative biosynthesis" EXACT []
synonym: "folate and derivative biosynthetic process" EXACT []
synonym: "folate-containing compound biosynthesis" EXACT [GOC:curators]
synonym: "folate-containing compound biosynthetic process" EXACT [GOC:curators]
synonym: "folic acid and derivative biosynthesis" EXACT []
synonym: "folic acid and derivative biosynthetic process" EXACT [GOC:curators]
synonym: "folic acid-containing compound anabolism" EXACT [GOC:curators]
synonym: "folic acid-containing compound biosynthesis" EXACT [GOC:curators]
synonym: "folic acid-containing compound formation" EXACT [GOC:curators]
synonym: "folic acid-containing compound synthesis" EXACT [GOC:curators]
synonym: "vitamin B9 and derivative biosynthesis" EXACT []
synonym: "vitamin B9 and derivative biosynthetic process" EXACT []
synonym: "vitamin M and derivative biosynthesis" EXACT []
synonym: "vitamin M and derivative biosynthetic process" EXACT []
is_a: GO:0006760 ! folic acid-containing compound metabolic process
is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0042398 ! cellular modified amino acid biosynthetic process
is_a: GO:0042559 ! pteridine-containing compound biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process
is_a: GO:1901607 ! alpha-amino acid biosynthetic process

[Term]
id: GO:0009397
name: folic acid-containing compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of folic acid and its derivatives." [GOC:ai]
subset: gosubset_prok
synonym: "folate and derivative catabolic process" EXACT []
synonym: "folate and derivative catabolism" EXACT []
synonym: "folate-containing compound catabolic process" EXACT [GOC:curators]
synonym: "folate-containing compound catabolism" EXACT [GOC:curators]
synonym: "folic acid and derivative catabolic process" EXACT [GOC:curators]
synonym: "folic acid and derivative catabolism" EXACT []
synonym: "folic acid-containing compound breakdown" EXACT [GOC:curators]
synonym: "folic acid-containing compound catabolism" EXACT [GOC:curators]
synonym: "folic acid-containing compound degradation" EXACT [GOC:curators]
synonym: "vitamin B9 and derivative catabolic process" EXACT []
synonym: "vitamin B9 and derivative catabolism" EXACT []
synonym: "vitamin M and derivative catabolic process" EXACT []
synonym: "vitamin M and derivative catabolism" EXACT []
is_a: GO:0006760 ! folic acid-containing compound metabolic process
is_a: GO:0009109 ! coenzyme catabolic process
is_a: GO:0042219 ! cellular modified amino acid catabolic process
is_a: GO:0042560 ! pteridine-containing compound catabolic process
is_a: GO:1901606 ! alpha-amino acid catabolic process

[Term]
id: GO:0009398
name: FMN biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of FMN, the oxidized form of flavin mononucleotide (riboflavin 5'-(dihydrogen phosphate)), which acts as a coenzyme for a number of oxidative enzymes including NADH dehydrogenase." [CHEBI:17621, GOC:ai]
subset: gosubset_prok
synonym: "FMN anabolism" EXACT []
synonym: "FMN biosynthesis" EXACT []
synonym: "FMN formation" EXACT []
synonym: "FMN synthesis" EXACT []
is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0009156 ! ribonucleoside monophosphate biosynthetic process
is_a: GO:0009260 ! ribonucleotide biosynthetic process
is_a: GO:0042727 ! flavin-containing compound biosynthetic process
is_a: GO:0046444 ! FMN metabolic process

[Term]
id: GO:0009399
name: nitrogen fixation
namespace: biological_process
def: "The process in which nitrogen is taken from its relatively inert molecular form (N2) in the atmosphere and converted into nitrogen compounds useful for other chemical processes, such as ammonia, nitrate and nitrogen dioxide." [Wikipedia:Nitrogen_fixation]
subset: gosubset_prok
xref: MetaCyc:N2FIX-PWY
xref: Wikipedia:Nitrogen_fixation
is_a: GO:0071941 ! nitrogen cycle metabolic process

[Term]
id: GO:0009400
name: receptor signaling protein serine/threonine phosphatase activity
namespace: molecular_function
def: "Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate." [GOC:bf, GOC:mah]
synonym: "receptor signalling protein serine/threonine phosphatase activity" EXACT []
is_a: GO:0004722 ! protein serine/threonine phosphatase activity
is_a: GO:0005057 ! receptor signaling protein activity

[Term]
id: GO:0009401
name: phosphoenolpyruvate-dependent sugar phosphotransferase system
namespace: biological_process
def: "The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC." [http://www.ucs.mun.ca/~n55lrb/general_pts.html]
subset: gosubset_prok
synonym: "PTS system" NARROW []
is_a: GO:0008643 ! carbohydrate transport

[Term]
id: GO:0009402
name: obsolete toxin resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process.
synonym: "toxin resistance" EXACT []
is_obsolete: true
replaced_by: GO:0009636

[Term]
id: GO:0009403
name: toxin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism." [GOC:go_curators]
subset: gosubset_prok
synonym: "toxin anabolism" EXACT []
synonym: "toxin biosynthesis" EXACT []
synonym: "toxin formation" EXACT []
synonym: "toxin synthesis" EXACT []
is_a: GO:0009404 ! toxin metabolic process
is_a: GO:0044249 ! cellular biosynthetic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process

[Term]
id: GO:0009404
name: toxin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism." [GOC:cab2]
subset: goslim_aspergillus
subset: goslim_metagenomics
subset: goslim_pir
subset: gosubset_prok
synonym: "toxin metabolism" EXACT []
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0044237 ! cellular metabolic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0009405
name: pathogenesis
namespace: biological_process
def: "The set of specific processes that generate the ability of an organism to cause disease in another." [GOC:go_curators]
comment: Note that this term should not be used to annotate gene products that are involved in the host response to pathogenesis. It should only be used to annotate those gene products involved in the generation of pathogenesis by the pathogen itself.
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
subset: goslim_metagenomics
subset: gosubset_prok
synonym: "channel-forming toxin activity" RELATED []
synonym: "cytotoxin activity" RELATED []
synonym: "endotoxin activity" RELATED []
synonym: "enterotoxin activity" RELATED []
synonym: "exotoxin activity" RELATED []
synonym: "lipoprotein toxin" RELATED []
synonym: "neurotoxin activity" RELATED []
synonym: "pore-forming toxin activity" RELATED []
synonym: "toxin activity" RELATED []
synonym: "virulence" RELATED []
is_a: GO:0051704 ! multi-organism process

[Term]
id: GO:0009406
name: obsolete virulence
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a phenotype rather than a biological process.
synonym: "virulence" EXACT []
is_obsolete: true
consider: GO:0009405
consider: GO:0016032

[Term]
id: GO:0009407
name: toxin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism." [GOC:go_curators]
subset: gosubset_prok
synonym: "toxin breakdown" EXACT []
synonym: "toxin catabolism" EXACT []
synonym: "toxin degradation" EXACT []
is_a: GO:0009404 ! toxin metabolic process
is_a: GO:0044248 ! cellular catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process

[Term]
id: GO:0009408
name: response to heat
namespace: biological_process
alt_id: GO:0006951
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr]
subset: goslim_yeast
subset: gosubset_prok
synonym: "response to heat shock" NARROW []
is_a: GO:0006950 ! response to stress
is_a: GO:0009266 ! response to temperature stimulus

[Term]
id: GO:0009409
name: response to cold
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism." [GOC:lr]
subset: gosubset_prok
synonym: "freezing tolerance" RELATED []
is_a: GO:0006950 ! response to stress
is_a: GO:0009266 ! response to temperature stimulus

[Term]
id: GO:0009410
name: response to xenobiotic stimulus
namespace: biological_process
alt_id: GO:0017104
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms." [GOC:jl]
subset: gosubset_prok
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0009411
name: response to UV
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:hb]
subset: gosubset_prok
synonym: "response to ultraviolet light stimulus" EXACT []
synonym: "response to ultraviolet radiation stimulus" EXACT []
synonym: "response to UV light stimulus" EXACT []
synonym: "response to UV radiation stimulus" EXACT []
is_a: GO:0009416 ! response to light stimulus

[Term]
id: GO:0009412
name: obsolete response to heavy metal
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heavy metal stimulus. Heavy metals are those metals that can form a coordination bond with a protein; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn." [GOC:ai]
comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information).
synonym: "response to heavy metal" EXACT []
is_obsolete: true
consider: GO:0010038

[Term]
id: GO:0009413
name: response to flooding
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating flooding, short-term immersion in water." [GOC:lr]
comment: Note that this term should not be confused with 'response to deep water ; GO:0030912'. Flooding refers to short-term immersion, whereas 'response to deep water ; GO:0030912' refers to standing in water throughout an organism's life cycle.
is_a: GO:0006950 ! response to stress
is_a: GO:0009415 ! response to water

[Term]
id: GO:0009414
name: response to water deprivation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water." [GOC:lr]
subset: gosubset_prok
synonym: "drought tolerance" RELATED []
synonym: "response to dehydration" EXACT []
synonym: "response to drought" EXACT []
synonym: "response to thirst" EXACT []
is_a: GO:0006950 ! response to stress
is_a: GO:0009415 ! response to water

[Term]
id: GO:0009415
name: response to water
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of water." [GOC:jl]
subset: gosubset_prok
synonym: "response to water stimulus" EXACT [GOC:dos]
is_a: GO:0001101 ! response to acid chemical
is_a: GO:0009628 ! response to abiotic stimulus
is_a: GO:0010035 ! response to inorganic substance
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0009416
name: response to light stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:go_curators, ISBN:0582227089]
subset: gosubset_prok
is_a: GO:0009314 ! response to radiation

[Term]
id: GO:0009417
name: obsolete fimbrin
namespace: cellular_component
def: "OBSOLETE. A class of proteins that are the subunit components of fimbria." [ISBN:0914826859]
comment: This term was made obsolete because it represents a class of gene products.
synonym: "fimbrin" EXACT []
is_obsolete: true
replaced_by: GO:0009289

[Term]
id: GO:0009418
name: pilus shaft
namespace: cellular_component
def: "The long, slender, mid section of a pilus." [GOC:jl]
subset: gosubset_prok
synonym: "fimbrial shaft" EXACT []
is_a: GO:0044443 ! pilus part

[Term]
id: GO:0009419
name: pilus tip
namespace: cellular_component
def: "The pointed extremity furthest from the cell of a pilus." [GOC:jl]
subset: gosubset_prok
synonym: "fimbrial tip" EXACT []
is_a: GO:0044443 ! pilus part

[Term]
id: GO:0009420
name: bacterial-type flagellum filament
namespace: cellular_component
def: "The long (approximately 20 nm), thin external structure of the flagellum, which acts as a propeller. Examples of this component are found in bacteria." [GOC:mtg_sensu, PMID:10572114, PMID:12624192]
subset: gosubset_prok
synonym: "flagellar filament" EXACT []
synonym: "flagellin-based flagellum filament" EXACT []
is_a: GO:0044461 ! bacterial-type flagellum part

[Term]
id: GO:0009421
name: bacterial-type flagellum filament cap
namespace: cellular_component
def: "The proteinaceous structure at the distal tip of the flagellar filament. Examples of this component are found in bacteria." [GOC:mtg_sensu, PMID:10572114, PMID:12624192]
subset: gosubset_prok
synonym: "flagellar filament cap" EXACT []
synonym: "flagellin-based flagellum filament cap" EXACT []
is_a: GO:0044461 ! bacterial-type flagellum part
relationship: part_of GO:0009420 ! bacterial-type flagellum filament

[Term]
id: GO:0009422
name: bacterial-type flagellum hook-filament junction
namespace: cellular_component
def: "The region of the flagellum where the hook and filament meet. Examples of this component are found in bacteria." [GOC:mah, GOC:mtg_sensu, PMID:10572114, PMID:12624192]
subset: gosubset_prok
synonym: "flagellar hook-filament junction" EXACT []
is_a: GO:0044461 ! bacterial-type flagellum part

[Term]
id: GO:0009423
name: chorismate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the unsymmetrical ether derived from phosphoenolpyruvate and 5-phosphoshikimic acid formed as an intermediate in the biosynthesis of aromatic amino acids and many other compounds." [GOC:sm, ISBN:0198547684]
subset: gosubset_prok
synonym: "chorismate anabolism" EXACT []
synonym: "chorismate biosynthesis" EXACT []
synonym: "chorismate formation" EXACT []
synonym: "chorismate synthesis" EXACT []
xref: MetaCyc:ARO-PWY
xref: Reactome:REACT_27268 "Chorismate via Shikimate Pathway, Mycobacterium tuberculosis"
is_a: GO:0043650 ! dicarboxylic acid biosynthetic process
is_a: GO:0046417 ! chorismate metabolic process

[Term]
id: GO:0009424
name: bacterial-type flagellum hook
namespace: cellular_component
def: "The portion of the flagellum that connects the filament to the basal body. Examples of this component are found in bacteria." [GOC:mtg_sensu, PMID:10572114, PMID:12624192]
subset: gosubset_prok
synonym: "flagellar hook" EXACT []
synonym: "flagellin-based flagellum hook" EXACT []
is_a: GO:0044461 ! bacterial-type flagellum part

[Term]
id: GO:0009425
name: bacterial-type flagellum basal body
namespace: cellular_component
def: "One of the three major substructures of the flagellin-based flagellum; a structure consisting of a rod, a series of rings, the Mot proteins, the switch complex and the flagellum-specific export apparatus. The rings anchor the flagellum to the cytoplasmic membrane (MS ring), the peptidoglycan (P ring) and the outer membrane (L ring). Examples of this component are found in bacteria." [GOC:mtg_sensu, PMID:10572114, PMID:12624192]
subset: gosubset_prok
synonym: "flagellar basal body" BROAD []
synonym: "flagellin-based flagellum basal body" EXACT []
is_a: GO:0044461 ! bacterial-type flagellum part

[Term]
id: GO:0009426
name: bacterial-type flagellum basal body, distal rod
namespace: cellular_component
def: "The portion of the central rod of the flagellar basal body that is distal to the cell membrane; spans most of the distance between the inner and outer membranes. Examples of this component are found in bacteria." [GOC:mtg_sensu, PMID:10572114, PMID:11133968, PMID:12624192]
subset: gosubset_prok
synonym: "flagellar basal body, distal rod" EXACT []
synonym: "flagellin-based flagellum basal body, distal rod" EXACT []
is_a: GO:0044461 ! bacterial-type flagellum part
relationship: part_of GO:0030694 ! bacterial-type flagellum basal body, rod

[Term]
id: GO:0009427
name: bacterial-type flagellum basal body, distal rod, L ring
namespace: cellular_component
def: "One of the rings of the flagellar basal body; anchors the basal body to the outer membrane. Examples of this component are found in bacteria." [GOC:mtg_sensu, PMID:10572114, PMID:12624192]
subset: gosubset_prok
synonym: "flagellar basal body, distal rod, L ring" EXACT []
synonym: "flagellin-based flagellum basal body, distal rod, L ring" EXACT []
is_a: GO:0044461 ! bacterial-type flagellum part
relationship: part_of GO:0009426 ! bacterial-type flagellum basal body, distal rod

[Term]
id: GO:0009428
name: bacterial-type flagellum basal body, distal rod, P ring
namespace: cellular_component
def: "One of the rings of the flagellar basal body; anchors the basal body to the peptidoglycan layer. Examples of this component are found in bacteria." [GOC:mtg_sensu, PMID:10572114, PMID:12624192]
subset: gosubset_prok
synonym: "flagellar basal body, distal rod, P ring" RELATED []
synonym: "flagellin-based flagellum basal body, distal rod, P ring" EXACT []
is_a: GO:0044461 ! bacterial-type flagellum part
relationship: part_of GO:0009426 ! bacterial-type flagellum basal body, distal rod

[Term]
id: GO:0009429
name: bacterial-type flagellum basal body, proximal rod
namespace: cellular_component
def: "The portion of the central rod of the flagellar basal body that is proximal to the cell membrane; proximal rod connects the distal rod to the flagellar motor. Examples of this component are found in bacteria." [GOC:mtg_sensu, PMID:10572114, PMID:11133968, PMID:12624192]
subset: gosubset_prok
synonym: "flagellar basal body, proximal rod" EXACT []
synonym: "flagellin-based flagellum basal body, proximal rod" EXACT []
is_a: GO:0044461 ! bacterial-type flagellum part
relationship: part_of GO:0030694 ! bacterial-type flagellum basal body, rod

[Term]
id: GO:0009431
name: bacterial-type flagellum basal body, MS ring
namespace: cellular_component
alt_id: GO:0009430
def: "One of the rings of the flagellar basal body; a double-flanged ring that anchors the basal body to the cytoplasmic membrane. Examples of this component are found in bacteria." [GOC:mtg_sensu, PMID:10572114, PMID:12624192]
subset: gosubset_prok
synonym: "flagellar basal body, mounting plate" BROAD []
synonym: "flagellar basal body, MS ring" EXACT []
synonym: "flagellin-based flagellum basal body, MS ring" EXACT []
is_a: GO:0044461 ! bacterial-type flagellum part
relationship: part_of GO:0009425 ! bacterial-type flagellum basal body

[Term]
id: GO:0009432
name: SOS response
namespace: biological_process
def: "An error-prone process for repairing damaged microbial DNA." [GOC:jl, PMID:16000023]
subset: gosubset_prok
xref: Wikipedia:SOS_response
is_a: GO:0031668 ! cellular response to extracellular stimulus
is_a: GO:0033554 ! cellular response to stress

[Term]
id: GO:0009433
name: bacterial-type flagellum basal body, C ring
namespace: cellular_component
def: "Cytoplasmic ring located at the base of the flagellar basal body; acts as a rotor; includes three switch proteins, which generate torque and can change their conformational state in a bimodal fashion, so that the motor direction can switch between clockwise and counterclockwise. Examples of this component are found in bacteria." [GOC:mtg_sensu, PMID:10572114, PMID:12624192]
subset: gosubset_prok
synonym: "flagellar basal body, C ring" EXACT []
synonym: "flagellin-based flagellum basal body, C ring" EXACT []
is_a: GO:0044461 ! bacterial-type flagellum part
relationship: part_of GO:0009425 ! bacterial-type flagellum basal body

[Term]
id: GO:0009435
name: NAD biosynthetic process
namespace: biological_process
alt_id: GO:0006736
def: "The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:jl, ISBN:0618254153]
subset: gosubset_prok
synonym: "NAD (oxidized) biosynthesis" EXACT []
synonym: "NAD (oxidized) biosynthetic process" EXACT []
synonym: "NAD (reduced) biosynthesis" EXACT []
synonym: "NAD (reduced) biosynthetic process" EXACT []
synonym: "NAD anabolism" EXACT []
synonym: "NAD biosynthesis" EXACT []
synonym: "NAD formation" EXACT []
synonym: "NAD synthesis" EXACT []
synonym: "NADH biosynthesis" EXACT []
synonym: "NADH biosynthetic process" EXACT []
synonym: "nicotinamide adenine dinucleotide biosynthesis" EXACT []
synonym: "nicotinamide adenine dinucleotide biosynthetic process" EXACT []
synonym: "oxidized NAD biosynthesis" EXACT []
synonym: "oxidized NAD biosynthetic process" EXACT []
synonym: "oxidized nicotinamide adenine dinucleotide biosynthesis" EXACT []
synonym: "oxidized nicotinamide adenine dinucleotide biosynthetic process" EXACT []
synonym: "reduced NAD biosynthesis" EXACT []
synonym: "reduced NAD biosynthetic process" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide biosynthesis" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide biosynthetic process" EXACT []
is_a: GO:0019359 ! nicotinamide nucleotide biosynthetic process
is_a: GO:0019674 ! NAD metabolic process

[Term]
id: GO:0009436
name: glyoxylate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glyoxylate, the anion of glyoxylic acid, HOC-COOH." [ISBN:0198506732]
subset: gosubset_prok
synonym: "glyoxylate breakdown" EXACT []
synonym: "glyoxylate catabolism" EXACT []
synonym: "glyoxylate degradation" EXACT []
xref: MetaCyc:GLYOXDEG-PWY
is_a: GO:0046185 ! aldehyde catabolic process
is_a: GO:0046487 ! glyoxylate metabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0009437
name: carnitine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "carnitine metabolism" EXACT []
synonym: "vitamin Bt metabolic process" EXACT []
synonym: "vitamin Bt metabolism" EXACT []
is_a: GO:0006577 ! amino-acid betaine metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0097164 ! ammonium ion metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process

[Term]
id: GO:0009438
name: methylglyoxal metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid." [CHEBI:17158, GOC:ai]
subset: gosubset_prok
synonym: "methylglyoxal bypass" NARROW []
synonym: "methylglyoxal metabolism" EXACT []
synonym: "methylglyoxal pathway" NARROW []
xref: MetaCyc:METHGLYUT-PWY
is_a: GO:0006081 ! cellular aldehyde metabolic process
is_a: GO:0042180 ! cellular ketone metabolic process

[Term]
id: GO:0009439
name: cyanate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cyanate, NCO-, the anion of cyanic acid." [ISBN:0198506732]
subset: gosubset_prok
synonym: "cyanate metabolism" EXACT []
xref: MetaCyc:CYANCAT-PWY
is_a: GO:0006082 ! organic acid metabolic process
is_a: GO:0034641 ! cellular nitrogen compound metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process

[Term]
id: GO:0009440
name: cyanate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cyanate, NCO-, the anion of cyanic acid." [ISBN:0198506732]
subset: gosubset_prok
synonym: "cyanate breakdown" EXACT []
synonym: "cyanate catabolism" EXACT []
synonym: "cyanate degradation" EXACT []
is_a: GO:0009439 ! cyanate metabolic process
is_a: GO:0044270 ! cellular nitrogen compound catabolic process
is_a: GO:0044712 ! single-organism catabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process

[Term]
id: GO:0009441
name: glycolate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycolate, the anion of hydroxyethanoic acid (glycolic acid)." [GOC:ai, ISBN:0198506732]
subset: gosubset_prok
synonym: "glycolate metabolism" EXACT []
xref: MetaCyc:GLYCOLATEMET-PWY
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0034308 ! primary alcohol metabolic process

[Term]
id: GO:0009442
name: allantoin assimilation pathway
namespace: biological_process
def: "The pathways by which allantoin is processed and converted to ureidoglycolate, and then into metabolically useful substrates. E. coli are able to utilize allantoin as a sole nitrogen source under anaerobic conditions by converting it to ureidoglycolate; this may be further metabolized to produce glyoxylate and thence 3-phosphoglycerate, or alternatively oxidized to oxolureate, which can converted into oxamate and carbamoylphosphate. This may then be further metabolized to CO2, NH4+ and ATP." [MetaCyc:PWY0-41]
subset: gosubset_prok
synonym: "allantoin catabolic process via ureidoglycolate" EXACT []
synonym: "allantoin catabolism via ureidoglycolate" EXACT []
synonym: "allantoin degradation pathway" RELATED []
xref: MetaCyc:PWY0-41
is_a: GO:0000256 ! allantoin catabolic process

[Term]
id: GO:0009443
name: pyridoxal 5'-phosphate salvage
namespace: biological_process
def: "Any process that generates pyridoxal 5'-phosphate, the active form of vitamin B6, from derivatives of it without de novo synthesis." [GOC:jl]
subset: gosubset_prok
synonym: "pyridoxal 5' phosphate salvage" EXACT []
xref: MetaCyc:PLPSAL-PWY
is_a: GO:0042823 ! pyridoxal phosphate biosynthetic process
is_a: GO:0043094 ! cellular metabolic compound salvage

[Term]
id: GO:0009444
name: pyruvate oxidation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the conversion of pyruvate to acetylphosphate." [MetaCyc:PYRUVOX-PWY]
subset: gosubset_prok
xref: MetaCyc:PYRUVOX-PWY
xref: Wikipedia:Pyruvate_decarboxylation
is_a: GO:0006090 ! pyruvate metabolic process
is_a: GO:0055114 ! oxidation-reduction process

[Term]
id: GO:0009445
name: putrescine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving putrescine, 1,4-diaminobutane; putrescine can be formed by decarboxylation of ornithine and is the metabolic precursor of spermidine and spermine." [GOC:ai]
subset: gosubset_prok
synonym: "putrescine metabolism" EXACT []
is_a: GO:0006595 ! polyamine metabolic process
is_a: GO:0097164 ! ammonium ion metabolic process

[Term]
id: GO:0009446
name: putrescine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane; putrescine can be synthesized from arginine or ornithine and is the metabolic precursor of spermidine and spermine." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "putrescine anabolism" EXACT []
synonym: "putrescine biosynthesis" EXACT []
synonym: "putrescine formation" EXACT []
synonym: "putrescine synthesis" EXACT []
is_a: GO:0006596 ! polyamine biosynthetic process
is_a: GO:0009445 ! putrescine metabolic process

[Term]
id: GO:0009447
name: putrescine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of putrescine, 1,4-diaminobutane; putrescine is the metabolic precursor of spermidine and spermine." [GOC:ai]
subset: gosubset_prok
synonym: "putrescine breakdown" EXACT []
synonym: "putrescine catabolism" EXACT []
synonym: "putrescine degradation" EXACT []
is_a: GO:0006598 ! polyamine catabolic process
is_a: GO:0009445 ! putrescine metabolic process

[Term]
id: GO:0009448
name: gamma-aminobutyric acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms." [ISBN:0198506732]
comment: See also the biological process term 'neurotransmitter metabolic process ; GO:0042133'.
subset: gosubset_prok
synonym: "4-aminobutanoate metabolic process" EXACT []
synonym: "4-aminobutanoate metabolism" EXACT []
synonym: "4-aminobutyrate metabolic process" EXACT []
synonym: "4-aminobutyrate metabolism" EXACT []
synonym: "GABA metabolic process" EXACT []
synonym: "GABA metabolism" EXACT []
synonym: "gamma-aminobutyric acid metabolism" EXACT []
is_a: GO:0006520 ! cellular amino acid metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0009449
name: gamma-aminobutyric acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms." [GOC:ai]
comment: See also the biological process term 'neurotransmitter biosynthetic process ; GO:0042136'.
synonym: "4-aminobutanoate biosynthesis" EXACT []
synonym: "4-aminobutanoate biosynthetic process" EXACT []
synonym: "4-aminobutyrate biosynthesis" EXACT []
synonym: "4-aminobutyrate biosynthetic process" EXACT []
synonym: "GABA biosynthesis" EXACT []
synonym: "GABA biosynthetic process" EXACT []
synonym: "gamma-aminobutyric acid anabolism" EXACT []
synonym: "gamma-aminobutyric acid biosynthesis" EXACT []
synonym: "gamma-aminobutyric acid formation" EXACT []
synonym: "gamma-aminobutyric acid synthesis" EXACT []
is_a: GO:0008652 ! cellular amino acid biosynthetic process
is_a: GO:0009448 ! gamma-aminobutyric acid metabolic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process

[Term]
id: GO:0009450
name: gamma-aminobutyric acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms." [GOC:ai]
comment: See also the biological process term 'neurotransmitter catabolic process ; GO:0042135'.
subset: gosubset_prok
synonym: "4-aminobutanoate catabolic process" EXACT []
synonym: "4-aminobutanoate catabolism" EXACT []
synonym: "4-aminobutyrate catabolic process" EXACT []
synonym: "4-aminobutyrate catabolism" EXACT []
synonym: "GABA catabolic process" EXACT []
synonym: "GABA catabolism" EXACT []
synonym: "gamma-aminobutyric acid breakdown" EXACT []
synonym: "gamma-aminobutyric acid catabolism" EXACT []
synonym: "gamma-aminobutyric acid degradation" EXACT []
xref: MetaCyc:4AMINOBUTMETAB-PWY
is_a: GO:0009063 ! cellular amino acid catabolic process
is_a: GO:0009448 ! gamma-aminobutyric acid metabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0009451
name: RNA modification
namespace: biological_process
alt_id: GO:0016547
def: "The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically." [GOC:go_curators, ISBN:1555811337]
comment: The term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing.
subset: goslim_yeast
subset: gosubset_prok
synonym: "RNA editing" NARROW [GOC:hjd]
xref: Wikipedia:RNA_editing
is_a: GO:0016070 ! RNA metabolic process
is_a: GO:0043412 ! macromolecule modification

[Term]
id: GO:0009452
name: 7-methylguanosine RNA capping
namespace: biological_process
def: "The sequence of enzymatic reactions by which the 5' cap structure, an inverted 7-methylguanosine linked via a 5'-5' triphosphate bridge (m7G(5')ppp(5')X) to the first transcribed residue, is added to a nascent transcript." [GOC:vw, PMID:9266685]
synonym: "m(7)G RNA capping" EXACT [GOC:bf, GOC:krc, GOC:mah]
synonym: "RNA capping" BROAD [GOC:krc, GOC:mah]
is_a: GO:0036260 ! RNA capping

[Term]
id: GO:0009453
name: energy taxis
namespace: biological_process
def: "The directed movement of a motile cell or organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates." [GOC:jl, PMID:11029423]
subset: gosubset_prok
synonym: "energytaxis" EXACT []
synonym: "taxis in response to energy source" EXACT []
is_a: GO:0042330 ! taxis

[Term]
id: GO:0009454
name: aerotaxis
namespace: biological_process
def: "The directed movement of a motile cell or organism in response to environmental oxygen." [GOC:jl, ISBN:0192801023]
subset: gosubset_prok
synonym: "taxis in response to atmospheric oxygen" EXACT []
is_a: GO:0006935 ! chemotaxis
is_a: GO:0009453 ! energy taxis

[Term]
id: GO:0009455
name: redox taxis
namespace: biological_process
def: "The directed movement of a motile cell or organism in response to redox potential." [GOC:jl, PMID:11029423]
synonym: "redoxtaxis" EXACT []
synonym: "taxis in response to redox potential" EXACT []
synonym: "taxis in response to redox stimulus" EXACT []
is_a: GO:0006935 ! chemotaxis
is_a: GO:0009453 ! energy taxis
is_a: GO:0051775 ! response to redox state

[Term]
id: GO:0009457
name: obsolete flavodoxin
namespace: molecular_function
def: "OBSOLETE. A group of small electron carriers, characteristic of anaerobic bacteria, photosynthetic bacteria, cyanobacteria and eukaryotic algae. Contain flavin mononucleotide." [GOC:kd]
comment: This term was made obsolete because it represents a class of gene products.
synonym: "flavodoxin" EXACT []
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0009458
name: obsolete cytochrome
namespace: molecular_function
def: "OBSOLETE. A hemeprotein whose characteristic mode of action involves transfer of reducing equivalents associated with a reversible change in oxidation state of the prosthetic group. This redox change involves a single electron, reversible equilibrium between the Fe(II) and Fe(III) states of the central iron atom." [PMID:1655423]
comment: This term was made obsolete because it represents a gene product.
synonym: "cytochrome" EXACT []
is_obsolete: true
consider: GO:0045153
consider: GO:0045154
consider: GO:0045155
consider: GO:0045156
consider: GO:0045157
consider: GO:0045158

[Term]
id: GO:0009459
name: obsolete cytochrome a
namespace: molecular_function
def: "OBSOLETE. A cytochrome containing heme a." [GOC:kd]
comment: This term was made obsolete because it represents a gene product.
synonym: "cytochrome a" EXACT []
is_obsolete: true
replaced_by: GO:0045154

[Term]
id: GO:0009460
name: obsolete cytochrome b
namespace: molecular_function
def: "OBSOLETE. A cytochrome containing noncovalently bound protoheme (iron protoporphyrin IX; heme b)." [GOC:kd]
comment: This term was made obsolete because it represents a gene product.
synonym: "cytochrome b" EXACT []
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0009461
name: obsolete cytochrome c
namespace: molecular_function
def: "OBSOLETE. A cytochrome containing heme bound to the protein by one or, more (commonly two) thioether bonds involving sulfhydryl groups of cysteine residues." [GOC:kd]
comment: This term was made obsolete because it represents a gene product.
synonym: "cytochrome c" EXACT []
is_obsolete: true
replaced_by: GO:0045155

[Term]
id: GO:0009462
name: obsolete cytochrome d
namespace: molecular_function
def: "OBSOLETE. A cytochrome in which the prosthetic group is a tetrapyrrolic chelate of iron in which the degree of conjugation of double bonds is less than in porphyrin. This definition would appear to include siroheme proteins (e.g. nitrite and sulfite reductases), but these are not cytochromes." [GOC:kd, PMID:1655423]
comment: This term was made obsolete because it represents a gene product.
synonym: "cytochrome d" EXACT []
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0009463
name: obsolete cytochrome b/b6
namespace: molecular_function
def: "OBSOLETE. Diheme cytochrome b; cytochrome b has the hemes b(562) and b(566) and is a component of the mitochondrial respiratory chain complex III. Cytochrome b6 is a component of bc complex acting between photosystems II and I of photosynthesis." [ISBN:0198547684]
comment: This term was made obsolete because it represents a gene product.
synonym: "cytochrome b/b6" EXACT []
is_obsolete: true
replaced_by: GO:0045158

[Term]
id: GO:0009464
name: obsolete cytochrome b5
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "cytochrome b5" EXACT []
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0009465
name: obsolete soluble cytochrome b562
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "soluble cytochrome b562" EXACT []
is_obsolete: true
replaced_by: GO:0045153

[Term]
id: GO:0009466
name: obsolete class I cytochrome c
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "class I cytochrome c" EXACT []
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0009467
name: obsolete monoheme class I cytochrome c
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "monoheme class I cytochrome c" EXACT []
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0009468
name: obsolete diheme class I cytochrome c
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "diheme class I cytochrome c" EXACT []
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0009469
name: obsolete class II cytochrome c
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "class II cytochrome c" EXACT []
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0009470
name: obsolete class IIa cytochrome c
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "class IIa cytochrome c" EXACT []
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0009471
name: obsolete class III cytochrome c
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "class III cytochrome c" EXACT []
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0009472
name: obsolete cytochrome c3 (tetraheme)
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "cytochrome c3 (tetraheme)" EXACT []
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0009473
name: obsolete cytochrome c7 (triheme)
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "cytochrome c7 (triheme)" EXACT []
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0009474
name: obsolete nonaheme cytochrome c
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "nonaheme cytochrome c" EXACT []
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0009475
name: obsolete high-molecular-weight cytochrome c (hexadecaheme)
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "high-molecular-weight cytochrome c (hexadecaheme)" EXACT []
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0009476
name: obsolete class IV cytochrome c
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "class IV cytochrome c" EXACT []
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0009477
name: obsolete cytochrome c1
namespace: molecular_function
def: "OBSOLETE. A cytochrome c that is an integral component of the mitochondrial respiratory complex III. Functions as an electron donor to cytochrome c." [PMID:1655423]
comment: This term was made obsolete because it represents a gene product.
synonym: "cytochrome c1" EXACT []
is_obsolete: true
replaced_by: GO:0045153

[Term]
id: GO:0009478
name: obsolete cytochrome c554
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "cytochrome c554" EXACT []
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0009479
name: obsolete cytochrome f
namespace: molecular_function
def: "OBSOLETE. A cytochrome c that is characteristic of green plants and transfers electrons to plastocyanin." [PMID:1655423]
comment: This term was made obsolete because it represents a gene product.
synonym: "cytochrome f" EXACT []
is_obsolete: true
replaced_by: GO:0045158

[Term]
id: GO:0009480
name: obsolete class IIb cytochrome c
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "class IIb cytochrome c" EXACT []
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0009481
name: obsolete aa3-type cytochrome c oxidase
namespace: molecular_function
def: "OBSOLETE. Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1]
comment: This term was made obsolete because it describes a class of gene products rather than a molecular function.
synonym: "aa3-type cytochrome c oxidase" EXACT []
is_obsolete: true
replaced_by: GO:0004129

[Term]
id: GO:0009482
name: obsolete ba3-type cytochrome c oxidase
namespace: molecular_function
alt_id: GO:0009484
def: "OBSOLETE. Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1]
comment: This term was made obsolete because it describes a class of gene products rather than a molecular function.
synonym: "ba3-type cytochrome c oxidase" EXACT []
is_obsolete: true
replaced_by: GO:0004129

[Term]
id: GO:0009483
name: obsolete caa3-type cytochrome c oxidase
namespace: molecular_function
def: "OBSOLETE. Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1]
comment: This term was made obsolete because it describes a class of gene products rather than a molecular function.
synonym: "caa3-type cytochrome c oxidase" EXACT []
is_obsolete: true
replaced_by: GO:0004129

[Term]
id: GO:0009485
name: obsolete cbb3-type cytochrome c oxidase
namespace: molecular_function
def: "OBSOLETE. Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1]
comment: This term was made obsolete because it describes a class of gene products rather than a molecular function.
synonym: "cbb3-type cytochrome c oxidase" EXACT []
is_obsolete: true
replaced_by: GO:0004129

[Term]
id: GO:0009486
name: cytochrome bo3 ubiquinol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 ubiquinol + O2 + 4 H+ = 2 ubiquinone + 2 H2O + 4 H+ [periplasmic space]." [MetaCyc:RXN0-5268]
xref: EC:1.10.3.-
xref: MetaCyc:RXN0-5268
is_a: GO:0015002 ! heme-copper terminal oxidase activity

[Term]
id: GO:0009487
name: obsolete glutaredoxin
namespace: molecular_function
def: "OBSOLETE. A small disulfide-containing redox protein that serves as a glutathione-disulfide oxidoreductase." [GOC:kd]
comment: This term was made obsolete because it represent a gene product.
synonym: "glutaredoxin" EXACT []
is_obsolete: true
consider: GO:0003756
consider: GO:0015036
consider: GO:0015038

[Term]
id: GO:0009488
name: obsolete amicyanin
namespace: molecular_function
def: "OBSOLETE. A copper-containing protein that acts as an electron carrier between methylamine dehydrogenase and cytochrome c." [PMID:1655423]
comment: This term was made obsolete because it does not represent a molecular function.
synonym: "amicyanin" EXACT []
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0009489
name: obsolete rubredoxin
namespace: molecular_function
def: "OBSOLETE. A low molecular weight mononuclear iron protein involved in electron transfer, with an iron tetrahedrally coordinated by the sulfurs of four conserved cysteine residues." [GOC:kd]
comment: This term was made obsolete because it does not represent a molecular function.
synonym: "rubredoxin" EXACT []
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0009490
name: obsolete mononuclear iron electron carrier
namespace: molecular_function
def: "OBSOLETE. A mononuclear iron entity that serves as an electron acceptor and electron donor in an electron transport system." [GOC:ai]
comment: This term was made obsolete because it refers to a class of gene products.
synonym: "mononuclear iron electron carrier" EXACT []
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0009491
name: obsolete redox-active disulfide bond electron carrier
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it refers to a class of gene products.
synonym: "redox-active disulfide bond electron carrier" EXACT []
synonym: "redox-active disulphide bond electron carrier" EXACT []
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0009492
name: obsolete 2Fe-2S electron transfer carrier
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it refers to a class of gene products.
synonym: "2Fe-2S electron transfer carrier" EXACT []
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0009493
name: obsolete adrenodoxin-type ferredoxin
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it does not represent a function.
synonym: "adrenodoxin-type ferredoxin" EXACT []
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0009494
name: obsolete chloroplast-type ferredoxin
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it does not represent a function.
synonym: "chloroplast-type ferredoxin" EXACT []
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0009495
name: obsolete thioredoxin-like 2Fe-2S ferredoxin
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it does not represent a function.
synonym: "thioredoxin-like 2Fe-2S ferredoxin" EXACT []
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0009496
name: plastoquinol--plastocyanin reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 H(+)[side 1] + 2 oxidized plastocyanin + plastoquinol-1 = 2 H(+)[side 2] + 2 reduced plastocyanin + plastoquinone. This reaction involves the concomitant transfer of 2 H+ ions across a membrane." [EC:1.10.9.1]
subset: gosubset_prok
synonym: "cytochrome b6-f complex activity" RELATED [EC:1.10.9.1]
synonym: "cytochrome b6/f complex activity" RELATED [EC:1.10.9.1]
synonym: "cytochrome b6f" NARROW [EC:1.10.99.1]
synonym: "cytochrome b6f complex activity" RELATED [EC:1.10.9.1]
synonym: "plastoquinol-plastocyanin reductase activity" EXACT [EC:1.10.9.1]
synonym: "plastoquinol/plastocyanin oxidoreductase activity" EXACT [EC:1.10.99.1]
synonym: "plastoquinol:oxidized-plastocyanin oxidoreductase activity" EXACT [EC:1.10.99.1]
xref: EC:1.10.9.1
xref: KEGG:R03817
xref: MetaCyc:PLASTOQUINOL--PLASTOCYANIN-REDUCTASE-RXN
is_a: GO:0052880 ! oxidoreductase activity, acting on diphenols and related substances as donors, with copper protein as acceptor

[Term]
id: GO:0009497
name: obsolete 3Fe-4S/4Fe-4S electron transfer carrier
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it refers to a class of gene products.
synonym: "3Fe-4S/4Fe-4S electron transfer carrier" EXACT []
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0009498
name: obsolete bacterial-type ferredoxin
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it does not represent a function.
synonym: "bacterial-type ferredoxin" EXACT []
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0009499
name: obsolete monocluster bacterial-type ferredoxin
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it does not represent a function.
synonym: "monocluster bacterial-type ferredoxin" EXACT []
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0009500
name: obsolete dicluster bacterial-type ferredoxin
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it does not represent a function.
synonym: "dicluster bacterial-type ferredoxin" EXACT []
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0009501
name: amyloplast
namespace: cellular_component
def: "A plastid whose main function is to synthesize and store starch." [ISBN:0140514031]
xref: Wikipedia:Amyloplast
is_a: GO:0009536 ! plastid

[Term]
id: GO:0009502
name: obsolete photosynthetic electron transport chain
namespace: cellular_component
def: "OBSOLETE. A series of membrane-linked oxidation-reduction reactions in which electrons are transferred from an initial electron donor through a series of intermediates to a final electron acceptor (usually oxygen)." [GOC:mtg_electron_transport, ISBN:014051403]
comment: This term was made obsolete because it represents a process.
synonym: "photosynthetic electron transport chain" EXACT []
is_obsolete: true
consider: GO:0009767

[Term]
id: GO:0009503
name: thylakoid light-harvesting complex
namespace: cellular_component
def: "A thylakoid membrane complex of chlorophylls a and b together with chlorophyll a-b binding proteins. In addition, LHCs contain a number of other proteins, the function of which is speculative, together with accessory pigments. The LHCs capture and transfer energy to photosystems I and II. An example of this is found in Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:0198547684]
is_a: GO:0030076 ! light-harvesting complex
is_a: GO:0098807 ! chloroplast thylakoid membrane protein complex
intersection_of: GO:0030076 ! light-harvesting complex
intersection_of: part_of GO:0009535 ! chloroplast thylakoid membrane
relationship: part_of GO:0009535 ! chloroplast thylakoid membrane

[Term]
id: GO:0009504
name: cell plate
namespace: cellular_component
def: "The nascent cell membrane and cell wall structure that forms between two daughter nuclei near the center of a dividing plant cell. It develops at the equitorial region of the phragmoplast. It grows outwards to join with the lateral walls and form two daughter cells." [ISBN:0198547684]
xref: Wikipedia:Cell_plate
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0009505
name: plant-type cell wall
namespace: cellular_component
def: "A more or less rigid stucture lying outside the cell membrane of a cell and composed of cellulose and pectin and other organic and inorganic substances." [ISBN:0471245208]
synonym: "cellulose and pectin-containing cell wall" EXACT []
synonym: "plant cell wall" NARROW []
is_a: GO:0005618 ! cell wall

[Term]
id: GO:0009506
name: plasmodesma
namespace: cellular_component
def: "A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell." [ISBN:0198506732]
synonym: "plasmodesmata" EXACT []
xref: Wikipedia:Plasmodesma
is_a: GO:0005911 ! cell-cell junction
relationship: part_of GO:0055044 ! symplast

[Term]
id: GO:0009507
name: chloroplast
namespace: cellular_component
def: "A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma." [ISBN:0471245208]
xref: Wikipedia:Chloroplast
is_a: GO:0009536 ! plastid

[Term]
id: GO:0009508
name: plastid chromosome
namespace: cellular_component
def: "A circular DNA molecule containing plastid encoded genes." [ISBN:0943883999]
is_a: GO:0000229 ! cytoplasmic chromosome
is_a: GO:0044435 ! plastid part
intersection_of: GO:0005694 ! chromosome
intersection_of: part_of GO:0009536 ! plastid
relationship: part_of GO:0009536 ! plastid
relationship: part_of GO:0042646 ! plastid nucleoid

[Term]
id: GO:0009509
name: chromoplast
namespace: cellular_component
def: "A plastid containing pigments other than chlorophyll, usually yellow and orange carotenoid pigments." [ISBN:0471245208]
xref: Wikipedia:Chromoplast
is_a: GO:0009536 ! plastid

[Term]
id: GO:0009510
name: plasmodesmatal desmotubule
namespace: cellular_component
alt_id: GO:0009572
def: "A tightly wound cylinder of membrane that is located within the plasmodesmal pore and runs the length of the plasmodesma. The desmotubule likely provides a rigid stability to plasmodesmata and confers a fixed diameter and pore size to the plasmodesmal canal, and is linked to the endoplasmic reticulum in each of the adjacent cell." [http://biology.kenyon.edu/edwards/project/greg/pd.htm]
synonym: "desmotubule central rod" RELATED []
is_a: GO:0044432 ! endoplasmic reticulum part
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0009506 ! plasmodesma

[Term]
id: GO:0009511
name: plasmodesmatal endoplasmic reticulum
namespace: cellular_component
def: "Endoplasmic reticulum found in plasmodesmata, junctions connecting the cytoplasm of adjacent plant cells." [GOC:ai]
synonym: "plasmodesmatal ER" EXACT []
is_a: GO:0005783 ! endoplasmic reticulum
is_a: GO:0044432 ! endoplasmic reticulum part
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0009510 ! plasmodesmatal desmotubule

[Term]
id: GO:0009512
name: cytochrome b6f complex
namespace: cellular_component
def: "Complex that transfers electrons from reduced plastoquinone to oxidized plastocyanin and translocates protons from the stroma to the lumen. The complex contains a core structure of three catalytic subunits: cytochrome b, the Rieske iron sulfur protein (ISP), and cytochrome f, which are arranged in an integral membrane-bound dimeric complex; additional subunits are present, and vary among different species." [ISBN:0943883999, PMID:16228398, PMID:16352458]
subset: gosubset_prok
synonym: "cyt b(6)f complex" EXACT []
synonym: "cyt b6-f complex" EXACT []
synonym: "cyt b6/f complex" EXACT []
synonym: "cyt b6f complex" EXACT []
synonym: "cytochrome b(6)f complex" EXACT []
synonym: "cytochrome b6-f complex" EXACT []
synonym: "cytochrome b6/f complex" EXACT []
xref: Wikipedia:Cytochrome_b6f_complex
is_a: GO:0044436 ! thylakoid part
is_a: GO:0070069 ! cytochrome complex

[Term]
id: GO:0009513
name: etioplast
namespace: cellular_component
def: "A plastid arrested in the development of chloroplasts from proplastids due to absence of light or low light conditions." [ISBN:0943883999]
xref: Wikipedia:Etioplast
is_a: GO:0009536 ! plastid

[Term]
id: GO:0009514
name: glyoxysome
namespace: cellular_component
def: "A specialized form of peroxisome that contains the enzymes of the glyoxylate pathway. The glyoxysome is found in some plant cells, notably the cells of germinating seeds." [GOC:dhl, ISBN:0140514031]
xref: Wikipedia:Glyoxysome
is_a: GO:0005777 ! peroxisome

[Term]
id: GO:0009515
name: granal stacked thylakoid
namespace: cellular_component
def: "Appressed thylakoid membranes that are part of a granum (stacked regions). A characteristic of these appressed regions is the preferential localization of photosystem II." [GOC:lr]
synonym: "chloroplast stacked thylakoid" EXACT []
is_a: GO:0009534 ! chloroplast thylakoid
intersection_of: GO:0009534 ! chloroplast thylakoid
intersection_of: part_of GO:0009542 ! granum
relationship: part_of GO:0009542 ! granum

[Term]
id: GO:0009516
name: leucoplast
namespace: cellular_component
def: "A colorless plastid involved in the synthesis of monoterpenes." [ISBN:0943883999]
xref: Wikipedia:Leucoplast
is_a: GO:0009536 ! plastid

[Term]
id: GO:0009517
name: PSII associated light-harvesting complex II
namespace: cellular_component
def: "Protein-pigment complex associated with photosystem II." [GOC:lr, ISBN:0582227089]
synonym: "LHCII" EXACT []
is_a: GO:0009503 ! thylakoid light-harvesting complex

[Term]
id: GO:0009518
name: PSI associated light-harvesting complex I
namespace: cellular_component
def: "Protein-pigment complex associated with photosystem I." [GOC:lr]
synonym: "LHCI" EXACT []
is_a: GO:0009503 ! thylakoid light-harvesting complex

[Term]
id: GO:0009519
name: middle lamella
namespace: cellular_component
def: "Layer of intercellular material, chiefly pectic substances, cementing together the primary walls of contiguous cells." [ISBN:0471245208]
xref: Wikipedia:Middle_lamella
is_a: GO:0044420 ! extracellular matrix component

[Term]
id: GO:0009521
name: photosystem
namespace: cellular_component
alt_id: GO:0030090
def: "A complex located in a photosynthetic membrane that consists of a photoreaction center associated with accessory pigments and electron carriers. Examples of this component are found in Arabidopsis thaliana and in photosynthetic bacterial and archaeal species." [GOC:ds, GOC:mah, ISBN:0140514031, PMID:9821949]
subset: goslim_pir
subset: gosubset_prok
synonym: "reaction center" NARROW []
synonym: "reaction centre" NARROW []
xref: Wikipedia:Photosystem
is_a: GO:0044436 ! thylakoid part
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0034357 ! photosynthetic membrane

[Term]
id: GO:0009522
name: photosystem I
namespace: cellular_component
def: "A photosystem that contains an iron-sulfur reaction center associated with accessory pigments and electron carriers. In cyanobacteria and chloroplasts, photosystem I functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin; in photosynthetic bacteria that have only a single type I photosystem, such as the green sulfur bacteria, electrons can go either to ferredoxin (Fd) -> NAD+ or to menaquinone (MK) -> Cytb/FeS -> Cytc555 -> photosystem I (cyclic photophosphorylation)." [GOC:ds, GOC:mah, ISBN:0140514031, PMID:9821949]
subset: gosubset_prok
is_a: GO:0009521 ! photosystem

[Term]
id: GO:0009523
name: photosystem II
namespace: cellular_component
def: "A photosystem that contains a pheophytin-quinone reaction center with associated accessory pigments and electron carriers. In cyanobacteria and chloroplasts, in the presence of light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone, whereas other photosynthetic bacteria carry out anoxygenic photosynthesis and oxidize other compounds to re-reduce the photoreaction center." [GOC:ds, GOC:mah, ISBN:0943088399, PMID:9821949]
subset: gosubset_prok
xref: Wikipedia:Photosystem_II
is_a: GO:0009521 ! photosystem

[Term]
id: GO:0009524
name: phragmoplast
namespace: cellular_component
def: "Fibrous structure (light microscope view) that arises between the daughter nuclei at telophase and within which the initial partition (cell plate), dividing the mother cell in two (cytokinesis), is formed. Appears at first as a spindle connected to the two nuclei, but later spreads laterally in the form of a ring. Consists of microtubules." [ISBN:0471245208]
xref: Wikipedia:Phragmoplast
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0009525
name: phragmosome
namespace: cellular_component
def: "A flattened membranous vesicle containing cell wall components." [ISBN:0943883999]
xref: Wikipedia:Phragmosome
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0009526
name: plastid envelope
namespace: cellular_component
def: "The double lipid bilayer enclosing a plastid and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:jy]
is_a: GO:0031967 ! organelle envelope
is_a: GO:0044435 ! plastid part

[Term]
id: GO:0009527
name: plastid outer membrane
namespace: cellular_component
def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the plastid envelope." [GOC:lr]
is_a: GO:0031968 ! organelle outer membrane
is_a: GO:0042170 ! plastid membrane

[Term]
id: GO:0009528
name: plastid inner membrane
namespace: cellular_component
def: "The inner, i.e. lumen-facing, lipid bilayer of the plastid envelope; also faces the plastid stroma." [GOC:lr]
is_a: GO:0019866 ! organelle inner membrane
is_a: GO:0042170 ! plastid membrane

[Term]
id: GO:0009529
name: plastid intermembrane space
namespace: cellular_component
def: "The region between the inner and outer lipid bilayers of the plastid envelope." [GOC:lr]
synonym: "plastid envelope lumen" EXACT []
is_a: GO:0031970 ! organelle envelope lumen
is_a: GO:0044435 ! plastid part
relationship: part_of GO:0009526 ! plastid envelope

[Term]
id: GO:0009530
name: primary cell wall
namespace: cellular_component
def: "A plant cell wall that is still able to expand, permitting cell growth. Primary cell walls contain more pectin than secondary walls and no lignin is present." [GOC:jid, PMID:9442872]
is_a: GO:0009505 ! plant-type cell wall

[Term]
id: GO:0009531
name: secondary cell wall
namespace: cellular_component
def: "A plant cell wall that is no longer able to expand and so does not permit growth. Secondary cell walls contain less pectin that primary cell walls. The secondary cell is mostly composed of cellulose and is strengthened with lignin." [GOC:jid, ISBN:0943088399]
xref: Wikipedia:Secondary_cell_wall
is_a: GO:0009505 ! plant-type cell wall

[Term]
id: GO:0009532
name: plastid stroma
namespace: cellular_component
def: "The proteinaceous ground substance of plastids." [ISBN:047142520]
is_a: GO:0044435 ! plastid part

[Term]
id: GO:0009533
name: chloroplast stromal thylakoid
namespace: cellular_component
def: "Unstacked thylakoids that connect the grana stacks through the stroma." [ISBN:0943883999]
is_a: GO:0009534 ! chloroplast thylakoid
intersection_of: GO:0009534 ! chloroplast thylakoid
intersection_of: part_of GO:0009570 ! chloroplast stroma
relationship: part_of GO:0009570 ! chloroplast stroma

[Term]
id: GO:0009534
name: chloroplast thylakoid
namespace: cellular_component
def: "Sac-like membranous structures (cisternae) in a chloroplast combined into stacks (grana) and present singly in the stroma (stroma thylakoids or frets) as interconnections between grana. An example of this component is found in Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:0943883999]
is_a: GO:0031976 ! plastid thylakoid
is_a: GO:0044434 ! chloroplast part
intersection_of: GO:0009579 ! thylakoid
intersection_of: part_of GO:0009507 ! chloroplast
relationship: part_of GO:0009507 ! chloroplast

[Term]
id: GO:0009535
name: chloroplast thylakoid membrane
namespace: cellular_component
def: "The pigmented membrane of a chloroplast thylakoid. An example of this component is found in Arabidopsis thaliana." [GOC:lr, GOC:mtg_sensu]
is_a: GO:0044434 ! chloroplast part
is_a: GO:0055035 ! plastid thylakoid membrane
relationship: part_of GO:0009534 ! chloroplast thylakoid

[Term]
id: GO:0009536
name: plastid
namespace: cellular_component
def: "Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid." [GOC:jl, ISBN:0198547684]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
xref: Wikipedia:Plastid
is_a: GO:0043231 ! intracellular membrane-bounded organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0009537
name: proplastid
namespace: cellular_component
def: "The precursor of other plastids." [ISBN:0943883999]
is_a: GO:0009536 ! plastid

[Term]
id: GO:0009538
name: photosystem I reaction center
namespace: cellular_component
def: "A photochemical system containing P700, the chlorophyll a dimer that functions as a primary electron donor. Functioning as a light-dependent plastocyanin-ferredoxin oxidoreductase, it transfers electrons from plastocyanin to ferredoxin." [GOC:kd, ISBN:0943088399]
subset: gosubset_prok
synonym: "photosystem I reaction centre" EXACT []
is_a: GO:0044436 ! thylakoid part
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0009522 ! photosystem I

[Term]
id: GO:0009539
name: photosystem II reaction center
namespace: cellular_component
def: "An integral membrane complex containing P680, the chlorophyll a molecule that functions as a primary electron donor. In the light, functioning as a water-plastoquinone oxidoreductase, it transfers electrons from water to plastoquinone." [GOC:kd, ISBN:0943088399]
subset: gosubset_prok
synonym: "photosystem II reaction centre" EXACT []
is_a: GO:0044436 ! thylakoid part
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0009523 ! photosystem II

[Term]
id: GO:0009540
name: zeaxanthin epoxidase [overall] activity
namespace: molecular_function
def: "Catalysis of the reactions: zeaxanthin + NAD(P)H + H+ + O2 = antheraxanthin + NAD(P)+ + H2O; and antheraxanthin + NAD(P)H + H+ + O2 = violaxanthin + NAD(P)+ + H2O." [EC:1.14.13.90]
comment: This is a process composed of two reactions represented by the terms 'GO:0052662 : zeaxanthin epoxidase activity' and 'GO:0052663 : antheraxanthin epoxidase activity'.
synonym: "zea-epoxidase activity" RELATED [EC:1.14.13.90]
synonym: "zeaxanthin,NAD(P)H:oxygen oxidoreductase activity" RELATED [EC:1.14.13.90]
xref: EC:1.14.13.90
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0009541
name: etioplast prolamellar body
namespace: cellular_component
def: "A three dimensional regular lattice found in etioplasts. It is composed of a continuous system of tubules but when exposed to light the symmetrical arrangement is rapidly lost as tubules become pinched off into two dimensional sections of lattice. These for perforated sheets of membrane that move apart, extend and increase, finally establishing the typical granal and intergranal lamellae of the mature chloroplast." [ISBN:0140514031]
is_a: GO:0044435 ! plastid part
relationship: part_of GO:0009513 ! etioplast

[Term]
id: GO:0009542
name: granum
namespace: cellular_component
def: "Distinct stack of lamellae seen within chloroplasts. Grana contain the pigments, electron transfer compounds, and enzymes essential to the light-dependent reactions of photosynthesis." [ISBN:014051403]
is_a: GO:0044434 ! chloroplast part

[Term]
id: GO:0009543
name: chloroplast thylakoid lumen
namespace: cellular_component
def: "The cavity enclosed within the chloroplast thylakoid membrane. An example of this component is found in Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:006501037]
is_a: GO:0031978 ! plastid thylakoid lumen
is_a: GO:0044434 ! chloroplast part
relationship: part_of GO:0009534 ! chloroplast thylakoid

[Term]
id: GO:0009544
name: chloroplast ATP synthase complex
namespace: cellular_component
def: "The protein complex that catalyzes the phosphorylation of ADP to ATP in chloroplasts." [ISBN:019854768]
is_a: GO:0098807 ! chloroplast thylakoid membrane protein complex
relationship: part_of GO:0009535 ! chloroplast thylakoid membrane

[Term]
id: GO:0009545
name: elaioplast
namespace: cellular_component
def: "A leucoplast in which oil is stored." [ISBN:0140514031]
xref: Wikipedia:Elaioplast
is_a: GO:0009536 ! plastid

[Term]
id: GO:0009546
name: plasmodesmatal cytoplasmic sleeve
namespace: cellular_component
def: "The space between the plasma membrane and the desmotubule of a plasmodesma." [http://biology.kenyon.edu/edwards/project/greg/pd.htm]
synonym: "plasmodesmatal cytoplasmic annulus" EXACT []
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0009506 ! plasmodesma

[Term]
id: GO:0009547
name: plastid ribosome
namespace: cellular_component
def: "A ribosome contained within a plastid." [GOC:tair_curators]
is_a: GO:0000313 ! organellar ribosome
is_a: GO:0044435 ! plastid part
intersection_of: GO:0005840 ! ribosome
intersection_of: part_of GO:0009536 ! plastid
relationship: part_of GO:0009532 ! plastid stroma
relationship: part_of GO:0009536 ! plastid

[Term]
id: GO:0009548
name: plasmodesmatal plasma membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a plasmodesma." [GOC:mah]
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0009506 ! plasmodesma

[Term]
id: GO:0009549
name: cellulose microfibril
namespace: cellular_component
def: "A microfibril composed of cellulose arranged in orthogonal layers. Cellulose is a straight chain polysaccharide composed of B(14) linked glucose subunits. It is a major component of plant cell walls. Higher plant microfibrils are about 10nm in diameter and extremely long in relation to their width. The cellulose molecules are oriented parallel to the long axis of the microfibril in a paracrystalline array, which provides great tensile strength. The microfibrils are held in place by the wall matrix and their orientation is closely controlled by the cell." [GOC:jid, ISBN:0943088399]
is_a: GO:0044426 ! cell wall part
relationship: part_of GO:0009505 ! plant-type cell wall

[Term]
id: GO:0009550
name: primary plasmodesma
namespace: cellular_component
def: "A plasmodesma that consists of a simple, single channel; found predominantly in young tissue and formed as a function of cell plate formation during cytokinesis." [PMID:15012255]
synonym: "simple plasmodesma" EXACT []
is_a: GO:0009506 ! plasmodesma

[Term]
id: GO:0009551
name: secondary plasmodesma
namespace: cellular_component
def: "A plasmodesma with a branched structure, often with many channels leading into a larger central cavity; found in older tissues and usually derived from preexisting primary plasmodesmata." [PMID:15012255]
is_a: GO:0009506 ! plasmodesma

[Term]
id: GO:0009553
name: embryo sac development
namespace: biological_process
alt_id: GO:0048230
def: "The process whose specific outcome is the progression of the embryo sac over time, from its formation to the mature structure. The process begins with the meiosis of the megasporocyte to form four haploid megaspores. Three of the megaspores disintegrate, and the fourth undergoes mitosis giving rise to a binucleate syncytial embryo sac. The two haploid nuclei migrate to the opposite poles of the embryo sac and then undergo two rounds of mitosis generating four haploid nuclei at each pole. One nucleus from each set of four migrates to the center of the cell. Cellularization occurs, resulting in an eight-nucleate seven-celled structure. This structure contains two synergid cells and an egg cell at the micropylar end, and three antipodal cells at the other end. A binucleate endosperm mother cell is formed at the center. The two polar nuclei fuse resulting in a mononucleate diploid endosperm mother cell. The three antipodal cells degenerate." [GOC:mtg_plant, GOC:tb]
synonym: "female gametophyte development" EXACT []
is_a: GO:0048229 ! gametophyte development

[Term]
id: GO:0009554
name: megasporogenesis
namespace: biological_process
def: "The process in which the megasporocyte undergoes meiosis, giving rise to four haploid megaspores in the nucellus." [GOC:mtg_plant, GOC:tb]
synonym: "megaspore development" EXACT []
synonym: "megaspore mother cell meiosis" EXACT []
synonym: "meiosis of the megasporocyte" EXACT []
synonym: "meiotic division of the megasporocyte" EXACT []
is_a: GO:0048236 ! plant-type spore development
relationship: part_of GO:0009553 ! embryo sac development

[Term]
id: GO:0009555
name: pollen development
namespace: biological_process
alt_id: GO:0009564
alt_id: GO:0048231
def: "The process whose specific outcome is the progression of the pollen grain over time, from its formation to the mature structure. The process begins with the meiosis of the microsporocyte to form four haploid microspores. The nucleus of each microspore then divides by mitosis to form a two-celled organism, the pollen grain, that contains a tube cell as well as a smaller generative cell. The pollen grain is surrounded by an elaborate cell wall. In some species, the generative cell immediately divides again to give a pair of sperm cells. In most flowering plants, however this division takes place later, in the tube that develops when a pollen grain germinates." [GOC:mtg_plant, GOC:mtg_sensu, GOC:tb]
synonym: "formation of generative and vegetative cells" EXACT []
synonym: "male gametophyte development" EXACT []
synonym: "male gametophyte formation" EXACT []
synonym: "microgametophyte development" EXACT []
synonym: "pollen grain formation" EXACT []
is_a: GO:0048229 ! gametophyte development

[Term]
id: GO:0009556
name: microsporogenesis
namespace: biological_process
def: "The process in which the microsporocyte undergoes meiosis, giving rise to four haploid microspores." [GOC:mtg_plant, GOC:tb]
synonym: "microspore development" EXACT systematic_synonym []
is_a: GO:0048236 ! plant-type spore development
relationship: part_of GO:0009555 ! pollen development

[Term]
id: GO:0009557
name: antipodal cell differentiation
namespace: biological_process
def: "The process in which an uncellularized nucleus cellularizes and acquires the specialized features of an antipodal cell." [GOC:jid, GOC:mtg_plant]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0009561 ! megagametogenesis

[Term]
id: GO:0009558
name: embryo sac cellularization
namespace: biological_process
alt_id: GO:0009797
def: "The process in which the eight-nucleate single celled female gametophyte develops into the seven-celled female gametophyte. This mature structure contains two synergid cells and an egg cell at the micropylar end, and three antipodal cells at the other end. A binucleate endosperm mother cell is formed at the center. An example of this process is found in Arabidopsis thaliana." [GOC:jid, GOC:mtg_plant, GOC:mtg_sensu, ISBN:047186840X]
synonym: "cellularization of the embryo sac" EXACT [GOC:curators]
synonym: "female gametophyte cellularization" EXACT []
synonym: "megagametophyte cellularization" EXACT []
is_a: GO:0007349 ! cellularization
relationship: part_of GO:0009561 ! megagametogenesis

[Term]
id: GO:0009559
name: embryo sac central cell differentiation
namespace: biological_process
def: "The process in which the two uncellularized polar nuclei cellularize, fuse and acquire the specialized features of a mononucleate diploid central cell." [GOC:jid, GOC:mtg_plant]
synonym: "embryo sac endosperm mother cell differentiation" EXACT []
synonym: "female gametophyte central cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0009561 ! megagametogenesis

[Term]
id: GO:0009560
name: embryo sac egg cell differentiation
namespace: biological_process
alt_id: GO:0048233
def: "The process in which an uncellularized embryo sac nucleus cellularizes and acquires the specialized features of an egg cell. An example of this process is found in Arabidopsis thaliana." [GOC:jid, GOC:mtg_plant, GOC:mtg_sensu]
synonym: "female gamete generation" BROAD []
synonym: "female gametophyte egg cell differentiation" EXACT []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0007292 ! female gamete generation
relationship: part_of GO:0009561 ! megagametogenesis

[Term]
id: GO:0009561
name: megagametogenesis
namespace: biological_process
def: "The process whose specific outcome is the progression of the embryo sac over time, from its formation as the megaspore to the mature structure. The process begins when three of the four haploid megaspores disintegrate, and the fourth undergoes mitosis giving rise to a binucleate syncytial embryo sac. The two haploid nuclei migrate to the opposite poles of the embryo sac and then undergo two rounds of mitosis generating four haploid nuclei at each pole. One nucleus from each set of four migrates to the center of the cell. Cellularization occurs, resulting in an eight-nucleate seven-celled structure. This structure contains two synergid cells and an egg cell at the micropylar end, and three antipodal cells at the other end. A binucleate endosperm mother cell is formed at the center." [GOC:jl, GOC:mtg_plant]
synonym: "embryo sac development from the megaspore" EXACT systematic_synonym []
synonym: "megagametophyte nucleus division" EXACT []
xref: Wikipedia:Megagametogenesis
is_a: GO:0044707 ! single-multicellular organism process
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0009553 ! embryo sac development

[Term]
id: GO:0009562
name: embryo sac nuclear migration
namespace: biological_process
def: "The directed movement of an embryo sac nucleus to the pole or center of the cell." [GOC:jl, GOC:mtg_plant]
synonym: "embryo sac nucleus migration" EXACT []
synonym: "female gametophyte nuclear migration" EXACT []
synonym: "female gametophyte nucleus migration" EXACT []
synonym: "megagametophyte nuclear migration" EXACT []
synonym: "megagametophyte nucleus migration" EXACT []
is_a: GO:0007097 ! nuclear migration
relationship: part_of GO:0009561 ! megagametogenesis

[Term]
id: GO:0009563
name: synergid differentiation
namespace: biological_process
def: "The process in which an uncellularized nucleus cellularizes and acquires the specialized features of a synergid cell." [GOC:jid]
synonym: "synergid cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0009561 ! megagametogenesis

[Term]
id: GO:0009566
name: fertilization
namespace: biological_process
def: "The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." [GOC:tb, ISBN:0198506732]
synonym: "syngamy" EXACT []
xref: Wikipedia:Fertilisation
is_a: GO:0044702 ! single organism reproductive process
relationship: part_of GO:0019953 ! sexual reproduction

[Term]
id: GO:0009567
name: double fertilization forming a zygote and endosperm
namespace: biological_process
def: "Fertilization where one of the two sperm nuclei from the pollen tube fuses with the egg nucleus to form a 2n zygote, and the other fuses with the two polar nuclei to form the 3n primary endosperm nucleus and then develops into the endosperm. The ploidy level of the 2n zygote and 3n primary endosperm nucleus is determined by the ploidy level of the parents involved. An example of this component is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tb]
synonym: "double fertilization" EXACT []
is_a: GO:0009566 ! fertilization

[Term]
id: GO:0009568
name: amyloplast starch grain
namespace: cellular_component
def: "Plant storage body for amylose and amylopectin, 1-100um in diameter, and located in amyloplasts. Also contains small amounts of enzymes, amino acids, lipids and nucleic acids. The shape of the grain varies widely amongst species, but is often spherical or disk-shaped." [GOC:jl, PMID:11217978]
synonym: "amyloplast starch granule" EXACT []
is_a: GO:0043036 ! starch grain
intersection_of: GO:0043036 ! starch grain
intersection_of: part_of GO:0009501 ! amyloplast
relationship: part_of GO:0009501 ! amyloplast

[Term]
id: GO:0009569
name: chloroplast starch grain
namespace: cellular_component
def: "Plant storage body for amylose and amylopectin, 1-100um in diameter, and located in chloroplasts. Also contains small amounts of enzymes, amino acids, lipids and nucleic acids. The shape of the grain varies widely amongst species, but is often spherical or disk-shaped." [GOC:jl, ISBN:0198506732]
synonym: "chloroplast starch granule" EXACT []
is_a: GO:0043036 ! starch grain
is_a: GO:0044434 ! chloroplast part
intersection_of: GO:0043036 ! starch grain
intersection_of: part_of GO:0009507 ! chloroplast
relationship: part_of GO:0009507 ! chloroplast

[Term]
id: GO:0009570
name: chloroplast stroma
namespace: cellular_component
def: "The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis." [ISBN:0198547684]
is_a: GO:0009532 ! plastid stroma
is_a: GO:0044434 ! chloroplast part

[Term]
id: GO:0009571
name: proplastid stroma
namespace: cellular_component
def: "The space enclosed by the double membrane of a proplastid." [GOC:jl]
is_a: GO:0009532 ! plastid stroma
relationship: part_of GO:0009537 ! proplastid

[Term]
id: GO:0009573
name: chloroplast ribulose bisphosphate carboxylase complex
namespace: cellular_component
def: "A complex, located in the chloroplast, containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate. An example of this component is found in Arabidopsis thaliana." [GOC:mlg, GOC:mtg_sensu]
synonym: "chloroplast RubisCO complex" EXACT []
is_a: GO:0044434 ! chloroplast part
is_a: GO:0048492 ! ribulose bisphosphate carboxylase complex
intersection_of: GO:0048492 ! ribulose bisphosphate carboxylase complex
intersection_of: part_of GO:0009507 ! chloroplast
relationship: part_of GO:0009507 ! chloroplast
relationship: part_of GO:0009570 ! chloroplast stroma

[Term]
id: GO:0009574
name: preprophase band
namespace: cellular_component
def: "A dense band of microtubules, 1-3 pm wide, that appears just beneath the cell membrane before the start of cell division in the cells of higher plants. It precedes the onset of prophase and then disappears as mitosis begins, yet it somehow determines the plane of orientation of the new cell plate forming in late telophase and marks the zone of the parental cell wall where fusion with the growing cell plate ultimately occurs." [ISBN:0198506732]
xref: Wikipedia:Preprophase_band
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0015630 ! microtubule cytoskeleton

[Term]
id: GO:0009575
name: chromoplast stroma
namespace: cellular_component
def: "The space enclosed by the double membrane of a chromoplast but excluding the photosynthetic material." [GOC:jl]
is_a: GO:0009532 ! plastid stroma
relationship: part_of GO:0009509 ! chromoplast

[Term]
id: GO:0009576
name: leucoplast stroma
namespace: cellular_component
def: "The space enclosed by the double membrane of a leucoplast." [GOC:mah]
is_a: GO:0009532 ! plastid stroma
relationship: part_of GO:0009516 ! leucoplast

[Term]
id: GO:0009577
name: elaioplast stroma
namespace: cellular_component
def: "The space enclosed by the double membrane of an elaioplast." [GOC:mah]
is_a: GO:0009532 ! plastid stroma
relationship: part_of GO:0009545 ! elaioplast

[Term]
id: GO:0009578
name: etioplast stroma
namespace: cellular_component
def: "The space enclosed by the double membrane of an etioplast but excluding the prothylakoid space. It contains the etioplast DNA." [GOC:jl]
is_a: GO:0009532 ! plastid stroma
relationship: part_of GO:0009513 ! etioplast

[Term]
id: GO:0009579
name: thylakoid
namespace: cellular_component
def: "A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation." [GOC:ds, GOC:mtg_sensu, ISBN:0198506732]
comment: A thylakoid is not considered an organelle, but some thylakoids are part of organelles.
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "photosynthetic membrane" RELATED []
xref: Wikipedia:Thylakoid
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0009580
name: obsolete thylakoid (sensu Bacteria)
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because more specific children exist.
synonym: "thylakoid (sensu Bacteria)" EXACT []
is_obsolete: true
consider: GO:0030075
consider: GO:0042716

[Term]
id: GO:0009581
name: detection of external stimulus
namespace: biological_process
def: "The series of events in which an external stimulus is received by a cell and converted into a molecular signal." [GOC:hb]
subset: gosubset_prok
synonym: "perception of external stimulus" RELATED []
is_a: GO:0009605 ! response to external stimulus
is_a: GO:0051606 ! detection of stimulus

[Term]
id: GO:0009582
name: detection of abiotic stimulus
namespace: biological_process
def: "The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal." [GOC:hb]
subset: gosubset_prok
synonym: "perception of abiotic stimulus" RELATED []
is_a: GO:0009628 ! response to abiotic stimulus
is_a: GO:0051606 ! detection of stimulus

[Term]
id: GO:0009583
name: detection of light stimulus
namespace: biological_process
def: "The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal." [GOC:go_curators]
subset: gosubset_prok
synonym: "detection of light" EXACT []
synonym: "perception of light" RELATED []
is_a: GO:0009416 ! response to light stimulus
is_a: GO:0009581 ! detection of external stimulus
is_a: GO:0009582 ! detection of abiotic stimulus

[Term]
id: GO:0009584
name: detection of visible light
namespace: biological_process
def: "The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm." [GOC:go_curators, ISBN:0198506732]
synonym: "perception of visible light" RELATED []
is_a: GO:0009583 ! detection of light stimulus

[Term]
id: GO:0009585
name: red, far-red light phototransduction
namespace: biological_process
def: "The sequence of reactions within a cell required to convert absorbed photons from red or far-red light into a molecular signal; the red, far-red light range is defined as having a wavelength within the range 660-730 nm." [GOC:mah]
subset: gosubset_prok
synonym: "phytochrome signaling pathway" BROAD []
synonym: "red-sensitive opsin" RELATED []
is_a: GO:0007602 ! phototransduction
relationship: part_of GO:0010017 ! red or far-red light signaling pathway

[Term]
id: GO:0009587
name: obsolete phototrophin mediated phototransduction
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
synonym: "phototrophin mediated phototransduction" EXACT []
is_obsolete: true
replaced_by: GO:0007602

[Term]
id: GO:0009588
name: UV-A, blue light phototransduction
namespace: biological_process
def: "The sequence of reactions within a cell required to convert absorbed photons from UV-A or blue light into a molecular signal; the UV-A, blue light range is defined as having a wavelength within the range of 315 to 400 nm." [GOC:mah]
synonym: "blue-sensitive opsin" RELATED []
synonym: "short-wave-sensitive opsin" RELATED []
synonym: "violet-sensitive opsin" RELATED []
is_a: GO:0007602 ! phototransduction

[Term]
id: GO:0009589
name: detection of UV
namespace: biological_process
def: "The series of events in which an ultraviolet radiation (UV light) stimulus is received and converted into a molecular signal. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:dos, GOC:go_curators, GOC:hb, ISBN:0198506732]
synonym: "detection of ultraviolet light stimulus" EXACT []
synonym: "detection of ultraviolet radiation stimulus" EXACT []
synonym: "detection of UV light stimulus" EXACT []
synonym: "detection of UV radiation stimulus" EXACT []
synonym: "perception of UV" RELATED []
is_a: GO:0009411 ! response to UV
is_a: GO:0009583 ! detection of light stimulus

[Term]
id: GO:0009590
name: detection of gravity
namespace: biological_process
def: "The series of events in which a gravitational stimulus is received and converted into a molecular signal." [GOC:dos, GOC:hb]
synonym: "perception of gravity" RELATED []
is_a: GO:0009581 ! detection of external stimulus
is_a: GO:0009582 ! detection of abiotic stimulus
is_a: GO:0009629 ! response to gravity

[Term]
id: GO:0009591
name: obsolete perception of mechanical stimulus
namespace: biological_process
alt_id: GO:0007609
def: "OBSOLETE. The series of events by which a mechanical stimulus is received by a cell and converted into a molecular signal." [GOC:hb]
comment: This term was made obsolete because it was not clear whether the term applied to the whole process of taste perception or just the sensory transduction stage.
synonym: "perception of mechanical stimulus" EXACT []
is_obsolete: true
consider: GO:0050954

[Term]
id: GO:0009593
name: detection of chemical stimulus
namespace: biological_process
def: "The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal." [GOC:jl]
synonym: "chemoperception" EXACT []
synonym: "detection of chemical substance" EXACT []
synonym: "perception of chemical stimulus" RELATED []
synonym: "perception of chemical substance" RELATED []
is_a: GO:0051606 ! detection of stimulus
relationship: part_of GO:0042221 ! response to chemical

[Term]
id: GO:0009594
name: detection of nutrient
namespace: biological_process
def: "The series of events in which a nutrient stimulus is received by a cell and converted into a molecular signal." [GOC:jl]
synonym: "detection of nutrients" EXACT []
synonym: "nutrient sensing" RELATED []
synonym: "perception of nutrients" RELATED []
is_a: GO:0007584 ! response to nutrient
is_a: GO:0009593 ! detection of chemical stimulus

[Term]
id: GO:0009595
name: detection of biotic stimulus
namespace: biological_process
alt_id: GO:0009596
def: "The series of events in which a biotic stimulus, one caused or produced by a living organism, is received and converted into a molecular signal." [GOC:hb]
subset: gosubset_prok
synonym: "perception of biotic stimulus" RELATED []
is_a: GO:0009607 ! response to biotic stimulus
is_a: GO:0051606 ! detection of stimulus

[Term]
id: GO:0009597
name: detection of virus
namespace: biological_process
def: "The series of events in which a stimulus from a virus is received and converted into a molecular signal." [GOC:hb]
comment: GO:0009597 is not a child term of 'detection of symbiont ; GO:0009602' to allow annotation of a virus responding to another (often competing) virus.
subset: gosubset_prok
synonym: "perception of virus" RELATED []
is_a: GO:0009615 ! response to virus

[Term]
id: GO:0009600
name: detection of nematode
namespace: biological_process
def: "The series of events in which a stimulus from a nematode is received and converted into a molecular signal." [GOC:hb]
synonym: "perception of nematode" RELATED []
is_a: GO:0009624 ! response to nematode
is_a: GO:0098543 ! detection of other organism

[Term]
id: GO:0009601
name: detection of insect
namespace: biological_process
def: "The series of events in which a stimulus from an insect is received and converted into a molecular signal." [GOC:hb]
synonym: "perception of insect" RELATED []
is_a: GO:0009625 ! response to insect
is_a: GO:0098543 ! detection of other organism

[Term]
id: GO:0009602
name: detection of symbiont
namespace: biological_process
def: "The series of events in which a stimulus from a symbiont (an organism living in close physical association with an organism of a different species) is received and converted into a molecular signal. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:hb, ISBN:0198506732]
synonym: "perception of symbiont" RELATED []
is_a: GO:0009608 ! response to symbiont
is_a: GO:0098543 ! detection of other organism

[Term]
id: GO:0009603
name: detection of symbiotic fungus
namespace: biological_process
def: "The series of events in which a stimulus from a symbiotic fungus, a fungus living in close physical association with another organism, is received and converted into a molecular signal." [GOC:hb, ISBN:0198506732]
synonym: "detection of symbiotic fungi" EXACT []
synonym: "perception of symbiotic fungi" RELATED []
synonym: "perception of symbiotic fungus" RELATED []
is_a: GO:0009602 ! detection of symbiont
is_a: GO:0009610 ! response to symbiotic fungus
is_a: GO:0016046 ! detection of fungus

[Term]
id: GO:0009604
name: detection of symbiotic bacterium
namespace: biological_process
def: "The series of events in which a stimulus from a symbiotic bacterium, a bacterium living in close physical association with another organism, is received and converted into a molecular signal." [GOC:hb, ISBN:0198506732]
synonym: "detection of symbiotic bacteria" EXACT []
synonym: "perception of symbiotic bacteria" RELATED []
synonym: "perception of symbiotic bacterium" RELATED []
is_a: GO:0009602 ! detection of symbiont
is_a: GO:0009609 ! response to symbiotic bacterium
is_a: GO:0016045 ! detection of bacterium

[Term]
id: GO:0009605
name: response to external stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:hb]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
subset: goslim_plant
subset: gosubset_prok
synonym: "response to environmental stimulus" EXACT []
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0009606
name: tropism
namespace: biological_process
def: "The movement of an organism, or part of an organism, in response to an external source of stimulus, usually toward or away from it." [GOC:curators, ISBN:0877795088]
subset: goslim_plant
xref: Wikipedia:Tropism
is_a: GO:0009605 ! response to external stimulus

[Term]
id: GO:0009607
name: response to biotic stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism." [GOC:hb]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
subset: goslim_plant
subset: gosubset_prok
synonym: "response to biotic stress" NARROW []
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0009608
name: response to symbiont
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiont, an organism living with an organism of a different species in close physical association. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:hb, ISBN:0198506732]
synonym: "response of host to symbiont" RELATED []
is_a: GO:0051707 ! response to other organism

[Term]
id: GO:0009609
name: response to symbiotic bacterium
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiotic bacterium, a bacterium living in close physical association with another organism." [GOC:hb, ISBN:0198506732]
synonym: "response to symbiotic bacteria" EXACT []
is_a: GO:0009608 ! response to symbiont
is_a: GO:0009617 ! response to bacterium

[Term]
id: GO:0009610
name: response to symbiotic fungus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiotic fungus, a fungus living in close physical association with another organism." [GOC:hb, ISBN:0198506732]
synonym: "response to symbiotic fungi" EXACT []
is_a: GO:0009608 ! response to symbiont
is_a: GO:0009620 ! response to fungus

[Term]
id: GO:0009611
name: response to wounding
namespace: biological_process
alt_id: GO:0002245
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism." [GOC:go_curators]
synonym: "physiological response to wounding" EXACT []
is_a: GO:0006950 ! response to stress

[Term]
id: GO:0009612
name: response to mechanical stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus." [GOC:hb]
subset: gosubset_prok
synonym: "chemi-mechanical coupling" RELATED []
synonym: "mechanical stimulus response" EXACT []
is_a: GO:0009605 ! response to external stimulus
is_a: GO:0009628 ! response to abiotic stimulus

[Term]
id: GO:0009614
name: obsolete disease resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process.
synonym: "disease resistance" EXACT []
is_obsolete: true
replaced_by: GO:0051707

[Term]
id: GO:0009615
name: response to virus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus." [GOC:hb]
subset: gosubset_prok
synonym: "response to viruses" EXACT []
is_a: GO:0051707 ! response to other organism

[Term]
id: GO:0009616
name: virus induced gene silencing
namespace: biological_process
def: "Specific posttranscriptional gene inactivation ('silencing') both of viral gene(s), and host gene(s) homologous to the viral genes. This silencing is triggered by viral infection, and occurs through a specific decrease in the level of mRNA of both host and viral genes." [GOC:jl]
comment: Virus-induced gene silencing (VIGS) is a RNA-mediated post-transcriptional gene silencing mechanism that protects plants against foreign gene invasion.
synonym: "VIGS" EXACT []
synonym: "virus-induced gene silencing" EXACT []
is_a: GO:0045087 ! innate immune response
is_a: GO:0051607 ! defense response to virus
is_a: GO:0052018 ! modulation by symbiont of RNA levels in host
is_a: GO:0098586 ! cellular response to virus

[Term]
id: GO:0009617
name: response to bacterium
namespace: biological_process
alt_id: GO:0009618
alt_id: GO:0009680
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium." [GOC:hb]
subset: gosubset_prok
synonym: "response to bacteria" EXACT []
is_a: GO:0051707 ! response to other organism

[Term]
id: GO:0009619
name: obsolete resistance to pathogenic bacteria
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process.
synonym: "resistance to pathogenic bacteria" EXACT []
is_obsolete: true
replaced_by: GO:0009617

[Term]
id: GO:0009620
name: response to fungus
namespace: biological_process
alt_id: GO:0009621
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus." [GOC:hb]
synonym: "response to fungi" EXACT []
is_a: GO:0051707 ! response to other organism

[Term]
id: GO:0009622
name: obsolete resistance to pathogenic fungi
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process.
synonym: "resistance to pathogenic fungi" EXACT []
is_obsolete: true
replaced_by: GO:0009620

[Term]
id: GO:0009623
name: response to parasitic fungus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a parasitic fungus, a fungus which spends all or part of its life in or on another organism from which it obtains nourishment and/or protection." [GOC:hb, ISBN:0198506732]
synonym: "response to parasitic fungi" EXACT []
is_a: GO:0009610 ! response to symbiotic fungus

[Term]
id: GO:0009624
name: response to nematode
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a nematode." [GOC:hb]
synonym: "response to nematodes" EXACT []
is_a: GO:0051707 ! response to other organism

[Term]
id: GO:0009625
name: response to insect
namespace: biological_process
alt_id: GO:0043019
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from an insect." [GOC:hb]
synonym: "response to insects" EXACT []
is_a: GO:0051707 ! response to other organism

[Term]
id: GO:0009626
name: plant-type hypersensitive response
namespace: biological_process
def: "The rapid, localized death of plant cells in response to invasion by a pathogen." [ISBN:0582227089]
comment: Note that term is to be used to annotate gene products in the plant. To annotate symbiont gene products that induce the hypersensitive response, consider the biological process term 'modulation by symbiont of host defense-related programmed cell death ; GO:0034053'.
synonym: "HR" EXACT []
synonym: "HR-PCD" EXACT []
synonym: "plant hypersensitive response" EXACT []
is_a: GO:0033554 ! cellular response to stress
is_a: GO:0034050 ! host programmed cell death induced by symbiont
is_a: GO:0045087 ! innate immune response

[Term]
id: GO:0009627
name: systemic acquired resistance
namespace: biological_process
def: "The salicylic acid mediated response to a pathogen which confers broad spectrum resistance." [GOC:lr, ISBN:052143641]
synonym: "salicylic acid-dependent systemic resistance" EXACT []
xref: Wikipedia:Systemic_acquired_resistance
is_a: GO:0009814 ! defense response, incompatible interaction

[Term]
id: GO:0009628
name: response to abiotic stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus." [GOC:hb]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
subset: goslim_plant
subset: gosubset_prok
synonym: "response to abiotic stress" NARROW []
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0009629
name: response to gravity
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus." [GOC:hb]
synonym: "response to gravitational stimulus" EXACT []
is_a: GO:0009628 ! response to abiotic stimulus

[Term]
id: GO:0009630
name: gravitropism
namespace: biological_process
def: "The orientation of plant parts under the stimulation of gravity." [ISBN:0198547684]
synonym: "geotropism" EXACT []
xref: Wikipedia:Gravitropism
is_a: GO:0009606 ! tropism
is_a: GO:0009629 ! response to gravity

[Term]
id: GO:0009631
name: cold acclimation
namespace: biological_process
def: "Any process that increases freezing tolerance of an organism in response to low, nonfreezing temperatures." [GOC:syr]
subset: gosubset_prok
is_a: GO:0009409 ! response to cold

[Term]
id: GO:0009632
name: obsolete freezing tolerance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'tolerance' implies a phenotype rather than a biological process.
synonym: "freezing tolerance" EXACT []
is_obsolete: true
consider: GO:0009409

[Term]
id: GO:0009633
name: obsolete drought tolerance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'tolerance' implies a phenotype rather than a biological process.
synonym: "drought tolerance" EXACT []
is_obsolete: true
consider: GO:0009414
consider: GO:0009819

[Term]
id: GO:0009634
name: obsolete heavy metal sensitivity/resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process.
synonym: "heavy metal sensitivity/resistance" EXACT []
is_obsolete: true
consider: GO:0010038

[Term]
id: GO:0009635
name: response to herbicide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a herbicide stimulus. Herbicides are chemicals used to kill or control the growth of plants." [GOC:curators]
subset: gosubset_prok
synonym: "herbicide susceptibility/resistance" RELATED []
is_a: GO:0006950 ! response to stress
is_a: GO:0009636 ! response to toxic substance

[Term]
id: GO:0009636
name: response to toxic substance
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus." [GOC:lr]
subset: goslim_chembl
subset: gosubset_prok
synonym: "detoxification response" NARROW []
synonym: "toxin resistance" RELATED []
synonym: "toxin susceptibility/resistance" RELATED []
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0009637
name: response to blue light
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a blue light stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm." [GOC:ai, GOC:mtg_far_red]
synonym: "response to blue light stimulus" EXACT []
is_a: GO:0009416 ! response to light stimulus

[Term]
id: GO:0009638
name: phototropism
namespace: biological_process
def: "The movement of an organism, or part of an organism, in response to a light stimulus, usually toward or away from it." [GOC:jl, GOC:mtg_far_red, PMID:16870491]
xref: Wikipedia:Phototropism
is_a: GO:0009606 ! tropism
is_a: GO:0009637 ! response to blue light

[Term]
id: GO:0009639
name: response to red or far red light
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red or far red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:ai, GOC:mtg_far_red]
is_a: GO:0009416 ! response to light stimulus

[Term]
id: GO:0009640
name: photomorphogenesis
namespace: biological_process
def: "The control of plant growth, development, and differentiation by the duration and nature of light, independent of photosynthesis." [GOC:lr]
synonym: "plant development in response to light" EXACT systematic_synonym []
xref: Wikipedia:Photomorphogenesis
is_a: GO:0009639 ! response to red or far red light
is_a: GO:0009791 ! post-embryonic development

[Term]
id: GO:0009641
name: shade avoidance
namespace: biological_process
def: "Shade avoidance is a set of responses that plants display when they are subjected to the shade of another plant. It often includes elongation, altered flowering time, increased apical dominance and altered partitioning of resources. Plants are able to distinguish between the shade of an inanimate object (e.g. a rock) and the shade of another plant due to the altered balance between red and far-red light in the shade of a plant; this balance between red and far-red light is perceived by phytochrome." [Wikipedia:Shade_avoidance]
xref: Wikipedia:Shade_avoidance
is_a: GO:0009639 ! response to red or far red light

[Term]
id: GO:0009642
name: response to light intensity
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light intensity stimulus." [GOC:go_curators]
is_a: GO:0009416 ! response to light stimulus

[Term]
id: GO:0009643
name: photosynthetic acclimation
namespace: biological_process
def: "A response to light intensity in which exposure to medium-intensity light results in increased tolerance to high-intensity light." [GOC:mah, PMID:11069694]
synonym: "light acclimatization" EXACT [PMID:11069694]
synonym: "photoacclimation" EXACT [GOC:tb]
is_a: GO:0009642 ! response to light intensity

[Term]
id: GO:0009644
name: response to high light intensity
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high light intensity stimulus." [GOC:go_curators]
is_a: GO:0009642 ! response to light intensity

[Term]
id: GO:0009645
name: response to low light intensity stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low light intensity stimulus. Low light intensity is defined as a level of electromagnetic radiation at or below 0.1 micromols/m2." [GOC:go_curators, GOC:mtg_far_red]
is_a: GO:0009642 ! response to light intensity

[Term]
id: GO:0009646
name: response to absence of light
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an absence of light stimuli." [GOC:go_curators]
synonym: "response to darkness" RELATED []
is_a: GO:0009642 ! response to light intensity

[Term]
id: GO:0009647
name: skotomorphogenesis
namespace: biological_process
def: "The control of plant growth, development, and differentiation in response to growth in darkness." [http://www.plantphys.net/article.php?ch=t&id=63, PMID:15012288]
synonym: "etiolation" RELATED []
is_a: GO:0009646 ! response to absence of light
is_a: GO:0009791 ! post-embryonic development

[Term]
id: GO:0009648
name: photoperiodism
namespace: biological_process
def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a period of light or dark of a given length, measured relative to a particular duration known as the 'critical day length'. The critical day length varies between species." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862]
synonym: "response to day length" EXACT []
synonym: "response to night length" EXACT []
synonym: "response to photoperiod" EXACT []
xref: Wikipedia:Photoperiodism
is_a: GO:0009416 ! response to light stimulus

[Term]
id: GO:0009649
name: entrainment of circadian clock
namespace: biological_process
def: "The synchronization of a circadian rhythm to environmental time cues such as light." [GOC:jid]
synonym: "regulation of circadian rhythm phase" RELATED []
is_a: GO:0009605 ! response to external stimulus
is_a: GO:0042752 ! regulation of circadian rhythm

[Term]
id: GO:0009650
name: UV protection
namespace: biological_process
def: "Any process in which an organism or cell protects itself from ultraviolet radiation (UV), which may also result in resistance to repeated exposure to UV." [GOC:jl, GOC:ml]
subset: gosubset_prok
synonym: "ultraviolet protection" EXACT []
synonym: "ultraviolet resistance" RELATED []
synonym: "ultraviolet tolerance" RELATED []
synonym: "UV resistance" RELATED []
synonym: "UV tolerance" RELATED []
is_a: GO:0009411 ! response to UV

[Term]
id: GO:0009651
name: response to salt stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:jl]
subset: gosubset_prok
synonym: "response to ionic osmotic stress" EXACT []
synonym: "salinity response" EXACT []
is_a: GO:0006970 ! response to osmotic stress

[Term]
id: GO:0009652
name: thigmotropism
namespace: biological_process
def: "The movement of an organism, or part of an organism, such as leaves or tendrils, in response to a touch stimulus, usually toward or away from it." [GOC:jl, PMID:16153165]
xref: Wikipedia:Thigmotropism
is_a: GO:0009606 ! tropism
is_a: GO:0009612 ! response to mechanical stimulus

[Term]
id: GO:0009653
name: anatomical structure morphogenesis
namespace: biological_process
def: "The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125]
subset: goslim_plant
subset: gosubset_prok
synonym: "anatomical structure organization" EXACT []
synonym: "embryogenesis and morphogenesis" BROAD []
synonym: "morphogenesis" EXACT []
xref: Wikipedia:Morphogenesis
is_a: GO:0032502 ! developmental process
relationship: part_of GO:0048856 ! anatomical structure development

[Term]
id: GO:0009654
name: photosystem II oxygen evolving complex
namespace: cellular_component
def: "A complex, composed of a cluster of manganese, calcium and chloride ions bound to extrinsic proteins, that catalyzes the splitting of water to O2 and 4 H+. In cyanobacteria there are five extrinsic proteins in OEC (PsbO, PsbP-like, PsbQ-like, PsbU and PsbV), while in plants there are only three (PsbO, PsbP and PsbQ)." [GOC:cjm, InterPro:IPR002683]
subset: gosubset_prok
synonym: "OEC (PSII) complex" EXACT [GOC:cjm]
synonym: "oxygen evolving complex" EXACT [GOC:cjm]
xref: Wikipedia:Oxygen_evolving_complex
is_a: GO:0044436 ! thylakoid part
is_a: GO:0098796 ! membrane protein complex
is_a: GO:1990204 ! oxidoreductase complex
relationship: part_of GO:0009523 ! photosystem II
relationship: part_of GO:0042651 ! thylakoid membrane

[Term]
id: GO:0009655
name: PSII associated light-harvesting complex II, core complex
namespace: cellular_component
def: "The pigment-protein complex primarily associated to PSII in higher plants, green algae and cyanobacteria that directly transfers electrons to the reaction center." [GOC:lr]
subset: gosubset_prok
synonym: "PSII associated light-harvesting complex II, core complex, LHCIIa subcomplex" NARROW []
synonym: "PSII associated light-harvesting complex II, core complex, LHCIIc subcomplex" NARROW []
synonym: "PSII associated light-harvesting complex II, core complex, LHCIId subcomplex" NARROW []
is_a: GO:0098807 ! chloroplast thylakoid membrane protein complex
relationship: part_of GO:0009517 ! PSII associated light-harvesting complex II

[Term]
id: GO:0009656
name: PSII associated light-harvesting complex II, peripheral complex
namespace: cellular_component
def: "Pigment-protein complex primarily associated to PSII in plants, green algae and cyanobacteria. Involved in state transitions that cause migration to PSI under certain environmental conditions such as high light." [GOC:lr]
subset: gosubset_prok
is_a: GO:0098807 ! chloroplast thylakoid membrane protein complex
relationship: part_of GO:0009517 ! PSII associated light-harvesting complex II

[Term]
id: GO:0009657
name: plastid organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plastid." [GOC:mah]
subset: goslim_pir
synonym: "plastid organisation" EXACT [GOC:curators]
synonym: "plastid organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0009658
name: chloroplast organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the chloroplast." [GOC:jid]
synonym: "chloroplast organisation" EXACT [GOC:curators]
synonym: "chloroplast organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0009657 ! plastid organization

[Term]
id: GO:0009659
name: leucoplast organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a leucoplast. A leucoplast is a colorless plastid involved in the synthesis of monoterpenes." [GOC:jid]
synonym: "leucoplast organisation" EXACT [GOC:curators]
synonym: "leucoplast organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0009657 ! plastid organization

[Term]
id: GO:0009660
name: amyloplast organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an amyloplast. An amyloplast is a plastid whose main function is to synthesize and store starch." [GOC:jid]
synonym: "amyloplast organisation" EXACT [GOC:curators]
synonym: "amyloplast organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0009657 ! plastid organization

[Term]
id: GO:0009661
name: chromoplast organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the chromoplast. A chromoplast is a plastid containing pigments other than chlorophyll, usually yellow and orange carotenoid pigments." [GOC:jid]
synonym: "chromoplast organisation" EXACT [GOC:curators]
synonym: "chromoplast organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0009657 ! plastid organization

[Term]
id: GO:0009662
name: etioplast organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an etioplast. An etioplast is a plastid arrested in the development of chloroplasts from proplastids due to absence of light or low light conditions." [GOC:jid]
synonym: "etioplast organisation" EXACT [GOC:curators]
synonym: "etioplast organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0009657 ! plastid organization

[Term]
id: GO:0009663
name: plasmodesma organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plasmodesma, a fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell." [GOC:mah]
synonym: "plasmodesma organisation" EXACT [GOC:curators]
synonym: "plasmodesma organization and biogenesis" RELATED [GOC:curators]
synonym: "plasmodesmata organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0045216 ! cell-cell junction organization

[Term]
id: GO:0009664
name: plant-type cell wall organization
namespace: biological_process
def: "A process that results in the assembly and arrangement of constituent parts of the cellulose and pectin-containing cell wall, or in the disassembly of the cellulose and pectin-containing cell wall. This process is carried out at the cellular level. An example of this process is found in Arabidopsis thaliana." [GOC:jid, GOC:mtg_sensu]
synonym: "cell wall organization and biogenesis" NARROW []
synonym: "cellulose and pectin-containing cell wall organization and biogenesis" RELATED [GOC:mah]
synonym: "plant-type cell wall organisation" EXACT [GOC:curators]
synonym: "plant-type cell wall organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0071555 ! cell wall organization
is_a: GO:0071669 ! plant-type cell wall organization or biogenesis

[Term]
id: GO:0009665
name: plastid inheritance
namespace: biological_process
def: "The partitioning of plastids between daughter cells at cell division." [GOC:mah]
is_a: GO:0009657 ! plastid organization
is_a: GO:0048308 ! organelle inheritance

[Term]
id: GO:0009666
name: plastid outer membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the outer membrane of a plastid." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
synonym: "plastid outer membrane organisation" EXACT [GOC:curators]
synonym: "plastid outer membrane organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0009668 ! plastid membrane organization

[Term]
id: GO:0009667
name: plastid inner membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the inner membrane of a plastid." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
synonym: "plastid inner membrane organisation" EXACT [GOC:curators]
synonym: "plastid inner membrane organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0009668 ! plastid membrane organization

[Term]
id: GO:0009668
name: plastid membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of either of the lipid bilayers surrounding a plastid." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
synonym: "plastid membrane organisation" EXACT [GOC:curators]
synonym: "plastid membrane organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0044802 ! single-organism membrane organization
relationship: part_of GO:0009657 ! plastid organization

[Term]
id: GO:0009669
name: sucrose:monovalent cation symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sucrose(out) + monovalent cation(out) = sucrose(in) + monovalent cation(in)." [GOC:jy, TC:2.A.2.-.-, TC:2.A.2.4.1]
synonym: "sucrose permease activity" RELATED []
is_a: GO:0008515 ! sucrose transmembrane transporter activity
is_a: GO:0015486 ! glycoside-pentoside-hexuronide:cation symporter activity

[Term]
id: GO:0009670
name: triose-phosphate:phosphate antiporter activity
namespace: molecular_function
alt_id: GO:0015122
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: triose-phosphate(out) + phosphate(in) = triose-phosphate(in) + phosphate(out)." [GOC:bf, GOC:jl, GOC:mtg_transport, ISBN:0815340729, TC:2.A.7.-.-]
synonym: "dihydroxyacetone phosphate:phosphate antiporter activity" EXACT []
synonym: "TPT" RELATED []
synonym: "triose phosphate antiporter" EXACT []
synonym: "triose phosphate translocator" EXACT []
is_a: GO:0015301 ! anion:anion antiporter activity
is_a: GO:0071917 ! triose-phosphate transmembrane transporter activity

[Term]
id: GO:0009671
name: nitrate:proton symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nitrate(out) + H+(out) = nitrate(in) + H+(in)." [GOC:mah, PMID:10066586, PMID:1990981]
synonym: "nitrate(chlorate):hydrogen symporter activity" EXACT []
synonym: "nitrate(chlorate):proton symporter activity" EXACT []
synonym: "nitrate:hydrogen symporter activity" EXACT []
is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity
is_a: GO:0015112 ! nitrate transmembrane transporter activity
is_a: GO:0015296 ! anion:cation symporter activity

[Term]
id: GO:0009672
name: auxin:proton symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: auxin(out) + H+(out) = auxin(in) + H+(in)." [PMID:8688077]
synonym: "auxin:hydrogen symporter activity" EXACT []
is_a: GO:0015294 ! solute:cation symporter activity
is_a: GO:0080161 ! auxin transmembrane transporter activity
relationship: part_of GO:0015992 ! proton transport
relationship: part_of GO:0060918 ! auxin transport

[Term]
id: GO:0009673
name: low-affinity phosphate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of phosphate from one side of the membrane to the other. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [TC:2.A.20.-.-]
synonym: "low affinity phosphate transmembrane transporter activity" EXACT []
is_a: GO:0015114 ! phosphate ion transmembrane transporter activity

[Term]
id: GO:0009674
name: potassium:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Na+(out) = K+(in) + Na+(in)." [TC:2.A.38.3.1]
synonym: "high affinity potassium transporter" RELATED []
is_a: GO:0022820 ! potassium ion symporter activity

[Term]
id: GO:0009675
name: high-affinity sulfate:proton symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mah]
synonym: "high affinity sulfate:hydrogen symporter activity" EXACT []
synonym: "high affinity sulfate:proton symporter activity" EXACT []
synonym: "high affinity sulphate:hydrogen symporter activity" EXACT []
is_a: GO:0008512 ! sulfate:proton symporter activity

[Term]
id: GO:0009676
name: low-affinity sulfate:proton symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [GOC:mah, PMID:7568135]
synonym: "low affinity sulfate:hydrogen symporter activity" EXACT []
synonym: "low affinity sulfate:proton symporter activity" EXACT []
synonym: "low affinity sulphate:hydrogen symporter activity" EXACT []
is_a: GO:0008512 ! sulfate:proton symporter activity

[Term]
id: GO:0009677
name: double fertilization forming two zygotes
namespace: biological_process
def: "Rudimentary double fertilization where one of the two sperm nuclei from the pollen tube fuses with the egg nucleus to form a 2n zygote, and the other fuses with the ventral canal cell nucleus to form a second zygote, which soon degenerates. An example of this process is found in the Gnetophytes, such as Welwitschia mirabilis." [GOC:mtg_sensu, GOC:tb]
is_a: GO:0009566 ! fertilization

[Term]
id: GO:0009678
name: hydrogen-translocating pyrophosphatase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of pyrophosphate, which generates a proton motive force." [GOC:mtg_transport, ISBN:0815340729, TC:3.A.10.-.-]
subset: gosubset_prok
synonym: "proton-translocating pyrophosphatase activity" EXACT []
is_a: GO:0015405 ! P-P-bond-hydrolysis-driven transmembrane transporter activity
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0009679
name: hexose:proton symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose(out) + H+(out) = hexose(in) + H+(in)." [TC:2.A.1.-.-]
subset: gosubset_prok
synonym: "hexose:hydrogen symporter activity" EXACT []
is_a: GO:0005351 ! sugar:proton symporter activity
is_a: GO:0015149 ! hexose transmembrane transporter activity

[Term]
id: GO:0009682
name: induced systemic resistance
namespace: biological_process
def: "A response to non-pathogenic bacteria that confers broad spectrum systemic resistance to disease that does not depend upon salicylic acid signaling." [PMID:10234273]
is_a: GO:0042742 ! defense response to bacterium
is_a: GO:0045087 ! innate immune response

[Term]
id: GO:0009683
name: indoleacetic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving indole-3-acetic acid, a compound which functions as a growth regulator in plants." [GOC:mah]
subset: gosubset_prok
synonym: "IAA metabolic process" EXACT []
synonym: "indole acetic acid metabolic process" EXACT []
synonym: "indole acetic acid metabolism" EXACT []
synonym: "indoleacetic acid metabolism" EXACT []
is_a: GO:0009850 ! auxin metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0034754 ! cellular hormone metabolic process
is_a: GO:0042430 ! indole-containing compound metabolic process

[Term]
id: GO:0009684
name: indoleacetic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of indole-3-acetic acid, a compound which functions as a growth regulator in plants." [ISBN:0387969845]
subset: gosubset_prok
synonym: "IAA biosynthetic process" EXACT []
synonym: "indole acetic acid biosynthesis" EXACT []
synonym: "indole acetic acid biosynthetic process" EXACT []
synonym: "indole-3-acetate biosynthesis" EXACT []
synonym: "indole-3-acetate biosynthetic process" EXACT []
synonym: "indole-acetic acid biosynthesis" EXACT []
synonym: "indole-acetic acid biosynthetic process" RELATED []
synonym: "indoleacetic acid anabolism" EXACT []
synonym: "indoleacetic acid biosynthesis" EXACT []
synonym: "indoleacetic acid formation" EXACT []
synonym: "indoleacetic acid synthesis" EXACT []
is_a: GO:0009683 ! indoleacetic acid metabolic process
is_a: GO:0009851 ! auxin biosynthetic process
is_a: GO:0042435 ! indole-containing compound biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process

[Term]
id: GO:0009685
name: gibberellin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving gibberellin. Gibberellins are a class of highly modified terpenes that function as plant growth regulators." [ISBN:0387969845]
subset: gosubset_prok
synonym: "gibberellic acid metabolic process" NARROW []
synonym: "gibberellic acid metabolism" NARROW []
synonym: "gibberellin metabolism" EXACT []
is_a: GO:0016101 ! diterpenoid metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0009686
name: gibberellin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of gibberellin. Gibberellins are a class of highly modified terpenes that function as plant growth regulators." [ISBN:0387969845]
subset: gosubset_prok
synonym: "gibberellic acid anabolism" NARROW []
synonym: "gibberellic acid biosynthesis" NARROW []
synonym: "gibberellic acid biosynthetic process" NARROW []
synonym: "gibberellic acid formation" NARROW []
synonym: "gibberellic acid synthesis" NARROW []
synonym: "gibberellin biosynthesis" EXACT []
xref: MetaCyc:PWY-5035
xref: MetaCyc:PWY-5036
xref: MetaCyc:PWY-5052
xref: MetaCyc:PWY-5070
is_a: GO:0009685 ! gibberellin metabolic process
is_a: GO:0016102 ! diterpenoid biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process

[Term]
id: GO:0009687
name: abscisic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving abscisic acid, 5-(1-hydroxy-2,6,6,trimethyl-4-oxocyclohex-2-en-1-y1)-3-methylpenta-2,4-dienoic acid." [ISBN:0387969845]
subset: gosubset_prok
synonym: "abscisic acid metabolism" EXACT []
is_a: GO:0006714 ! sesquiterpenoid metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0043288 ! apocarotenoid metabolic process
is_a: GO:1902644 ! tertiary alcohol metabolic process

[Term]
id: GO:0009688
name: abscisic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of abscisic acid, 5-(1-hydroxy-2,6,6,trimethyl-4-oxocyclohex-2-en-1-y1)-3-methylpenta-2,4-dienoic acid." [ISBN:0387969845]
subset: gosubset_prok
synonym: "abscisic acid anabolism" EXACT []
synonym: "abscisic acid biosynthesis" EXACT []
synonym: "abscisic acid formation" EXACT []
synonym: "abscisic acid synthesis" EXACT []
xref: MetaCyc:PWY-695
is_a: GO:0009687 ! abscisic acid metabolic process
is_a: GO:0016106 ! sesquiterpenoid biosynthetic process
is_a: GO:0043289 ! apocarotenoid biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:1902645 ! tertiary alcohol biosynthetic process

[Term]
id: GO:0009689
name: induction of phytoalexin biosynthetic process
namespace: biological_process
def: "The activation of the chemical reactions and pathways resulting in the formation of phytoalexins, low-molecular mass, lipophilic antimicrobial compounds that accumulate rapidly at sites of incompatible pathogen infection." [ISBN:0943088399]
synonym: "induction of phytoalexin anabolism" EXACT []
synonym: "induction of phytoalexin biosynthesis" EXACT []
synonym: "induction of phytoalexin formation" EXACT []
synonym: "induction of phytoalexin synthesis" EXACT []
is_a: GO:0009814 ! defense response, incompatible interaction
is_a: GO:0052322 ! positive regulation of phytoalexin biosynthetic process

[Term]
id: GO:0009690
name: cytokinin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators." [ISBN:0387969845]
subset: goslim_chembl
subset: gosubset_prok
synonym: "cytokinin metabolism" EXACT []
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0009308 ! amine metabolic process
is_a: GO:0034754 ! cellular hormone metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0009691
name: cytokinin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators." [ISBN:0387969845]
subset: gosubset_prok
synonym: "cytokinin anabolism" EXACT []
synonym: "cytokinin biosynthesis" EXACT []
synonym: "cytokinin formation" EXACT []
synonym: "cytokinin synthesis" EXACT []
is_a: GO:0009690 ! cytokinin metabolic process
is_a: GO:0042446 ! hormone biosynthetic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0009692
name: ethylene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator." [ISBN:0387969845]
subset: gosubset_prok
synonym: "ethene metabolic process" EXACT []
synonym: "ethene metabolism" EXACT []
synonym: "ethylene metabolism" EXACT []
xref: Reactome:REACT_103035 "Ethylene is oxidized to Ethylene oxide by CYP1A1, Canis familiaris"
xref: Reactome:REACT_106979 "Ethylene is oxidized to Ethylene oxide by CYP1A1, Taeniopygia guttata"
xref: Reactome:REACT_112653 "Ethylene is oxidized to Ethylene oxide by CYP1A1, Gallus gallus"
xref: Reactome:REACT_113841 "Ethylene is oxidized to Ethylene oxide by CYP1A1, Danio rerio"
xref: Reactome:REACT_1447 "Ethylene is oxidized to Ethylene oxide by CYP1A1, Homo sapiens"
xref: Reactome:REACT_33790 "Ethylene is oxidized to Ethylene oxide by CYP1A1, Rattus norvegicus"
xref: Reactome:REACT_33859 "Ethylene is oxidized to Ethylene oxide by CYP1A1, Sus scrofa"
xref: Reactome:REACT_49029 "Ethylene is oxidized to Ethylene oxide by CYP1A1, Bos taurus"
xref: Reactome:REACT_84651 "Ethylene is oxidized to Ethylene oxide by CYP1A1, Mus musculus"
xref: Reactome:REACT_89132 "Ethylene is oxidized to Ethylene oxide by CYP1A1, Xenopus tropicalis"
is_a: GO:0043449 ! cellular alkene metabolic process

[Term]
id: GO:0009693
name: ethylene biosynthetic process
namespace: biological_process
alt_id: GO:0042456
def: "The chemical reactions and pathways resulting in the formation of ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator." [ISBN:0387969845]
subset: gosubset_prok
synonym: "ethene biosynthesis" EXACT []
synonym: "ethene biosynthesis from L-methionine" EXACT []
synonym: "ethene biosynthetic process" EXACT []
synonym: "ethene biosynthetic process from L-methionine" EXACT []
synonym: "ethylene anabolism" EXACT []
synonym: "ethylene biosynthesis" EXACT []
synonym: "ethylene biosynthesis from L-methionine" EXACT []
synonym: "ethylene biosynthetic process from L-methionine" EXACT []
synonym: "ethylene formation" EXACT []
synonym: "ethylene synthesis" EXACT []
xref: MetaCyc:ETHYL-PWY
is_a: GO:0009692 ! ethylene metabolic process
is_a: GO:0043450 ! alkene biosynthetic process

[Term]
id: GO:0009694
name: jasmonic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving jasmonic acid, a fatty acid derivative with the formula (1R-(1 alpha, 2 beta(Z)))-3-oxo-2-(2-pentenyl)cyclopentaneacetic acid." [ISBN:0387969845]
subset: gosubset_prok
synonym: "jasmonic acid metabolism" EXACT []
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0009695
name: jasmonic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of jasmonic acid, a fatty acid derivative." [ISBN:0387969845]
synonym: "jasmonic acid anabolism" EXACT []
synonym: "jasmonic acid biosynthesis" EXACT []
synonym: "jasmonic acid formation" EXACT []
synonym: "jasmonic acid synthesis" EXACT []
xref: MetaCyc:PWY-735
is_a: GO:0009694 ! jasmonic acid metabolic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process

[Term]
id: GO:0009696
name: salicylic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving of salicylic acid (2-hydroxybenzoic acid), a derivative of benzoic acid." [ISBN:0943088399]
subset: gosubset_prok
synonym: "salicylic acid metabolism" EXACT []
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:0009697
name: salicylic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of salicylic acid (2-hydroxybenzoic acid), a derivative of benzoic acid." [ISBN:0943088399]
subset: gosubset_prok
synonym: "salicylate biosynthetic process" EXACT []
synonym: "salicylic acid anabolism" EXACT []
synonym: "salicylic acid biosynthesis" EXACT []
synonym: "salicylic acid formation" EXACT []
synonym: "salicylic acid synthesis" EXACT []
xref: MetaCyc:PWY-981
is_a: GO:0009696 ! salicylic acid metabolic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process

[Term]
id: GO:0009698
name: phenylpropanoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aromatic derivatives of trans-cinnamic acid." [GOC:jl]
subset: gosubset_prok
synonym: "phenylpropanoid metabolism" EXACT []
xref: MetaCyc:PWY1F-467
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:1901360 ! organic cyclic compound metabolic process

[Term]
id: GO:0009699
name: phenylpropanoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of aromatic derivatives of trans-cinnamic acid." [GOC:jl]
subset: gosubset_prok
synonym: "phenylpropanoid anabolism" EXACT []
synonym: "phenylpropanoid biosynthesis" EXACT []
synonym: "phenylpropanoid formation" EXACT []
synonym: "phenylpropanoid synthesis" EXACT []
is_a: GO:0009698 ! phenylpropanoid metabolic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process

[Term]
id: GO:0009700
name: indole phytoalexin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of indole phytoalexins, any indole compound produced by plants as part of their defense response." [GOC:sm, ISBN:0198547684]
synonym: "indole phytoalexin anabolism" EXACT []
synonym: "indole phytoalexin biosynthesis" EXACT []
synonym: "indole phytoalexin formation" EXACT []
synonym: "indole phytoalexin synthesis" EXACT []
is_a: GO:0042435 ! indole-containing compound biosynthetic process
is_a: GO:0046217 ! indole phytoalexin metabolic process
is_a: GO:0052315 ! phytoalexin biosynthetic process

[Term]
id: GO:0009701
name: isoflavonoid phytoalexin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of isoflavonoid phytoalexins, a group of water-soluble phenolic derivatives isomeric with flavonoids that possess antibiotic activity and are produced by plant tissues in response to infection." [GOC:ai]
synonym: "isoflavonoid phytoalexin anabolism" EXACT []
synonym: "isoflavonoid phytoalexin biosynthesis" EXACT []
synonym: "isoflavonoid phytoalexin formation" EXACT []
synonym: "isoflavonoid phytoalexin synthesis" EXACT []
is_a: GO:0009717 ! isoflavonoid biosynthetic process
is_a: GO:0046289 ! isoflavonoid phytoalexin metabolic process
is_a: GO:0052315 ! phytoalexin biosynthetic process

[Term]
id: GO:0009702
name: L-arabinokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arabinose + ATP = beta-L-arabinose 1-phosphate + ADP + 2 H(+)." [EC:2.7.1.46, RHEA:20156]
synonym: "ATP:L-arabinose 1-phosphotransferase activity" EXACT []
synonym: "L-arabinokinase (phosphorylating)" EXACT [EC:2.7.1.46]
xref: EC:2.7.1.46
xref: KEGG:R01754
xref: MetaCyc:L-ARABINOKINASE-RXN
xref: RHEA:20156
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0009703
name: nitrate reductase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: nitrite + NAD+ + H2O = nitrate + NADH + H+." [EC:1.7.1.1]
comment: Note that this function was formerly EC:1.6.6.1.
synonym: "assimilatory NADH: nitrate reductase activity" EXACT [EC:1.7.1.1]
synonym: "assimilatory NADH:nitrate reductase activity" EXACT [EC:1.7.1.1]
synonym: "assimilatory nitrate reductase activity" BROAD [EC:1.7.1.1]
synonym: "NADH-dependent nitrate reductase activity" EXACT [EC:1.7.1.1]
synonym: "NADH-nitrate reductase activity" EXACT [EC:1.7.1.1]
synonym: "NADH:nitrate oxidoreductase activity" EXACT [EC:1.7.1.1]
synonym: "NADH:nitrate reductase activity" EXACT []
synonym: "nitrate reductase (NADH(2)) activity" EXACT [EC:1.7.1.1]
synonym: "nitrate reductase (NADH2)" EXACT [EC:1.7.1.1]
synonym: "nitrite:NAD+ oxidoreductase activity" EXACT [EC:1.7.1.1]
xref: EC:1.7.1.1
xref: MetaCyc:NITRATE-REDUCTASE-NADH-RXN
xref: RHEA:17916
is_a: GO:0008940 ! nitrate reductase activity
is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor

[Term]
id: GO:0009704
name: de-etiolation
namespace: biological_process
def: "The greening response of plants grown in the dark (etiolated) as a result of chloroplast biogenesis and the accumulation of chlorophyll." [GOC:lr]
is_a: GO:0009416 ! response to light stimulus
relationship: part_of GO:0009640 ! photomorphogenesis

[Term]
id: GO:0009705
name: plant-type vacuole membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a vacuole that retains the same shape regardless of cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this component is found in Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:0471245208]
synonym: "membrane of vacuole with cell cycle-independent morphology" EXACT []
synonym: "tonoplast" EXACT []
synonym: "vacuolar membrane" BROAD []
is_a: GO:0005774 ! vacuolar membrane
relationship: part_of GO:0000325 ! plant-type vacuole

[Term]
id: GO:0009706
name: chloroplast inner membrane
namespace: cellular_component
def: "The inner, i.e. lumen-facing, lipid bilayer of the chloroplast envelope; also faces the chloroplast stroma." [GOC:tb]
synonym: "chloroplast inner envelope" EXACT []
is_a: GO:0009528 ! plastid inner membrane
is_a: GO:0031969 ! chloroplast membrane

[Term]
id: GO:0009707
name: chloroplast outer membrane
namespace: cellular_component
def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the chloroplast envelope." [GOC:tb]
synonym: "chloroplast outer envelope" EXACT []
is_a: GO:0009527 ! plastid outer membrane
is_a: GO:0031969 ! chloroplast membrane

[Term]
id: GO:0009708
name: benzyl isoquinoline alkaloid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of benzyl isoquinoline alkaloids, compounds with bicyclic N-containing aromatic rings." [GOC:ai, ISBN:0198506732]
subset: gosubset_prok
synonym: "benzyl isoquinoline alkaloid anabolism" EXACT []
synonym: "benzyl isoquinoline alkaloid biosynthesis" EXACT []
synonym: "benzyl isoquinoline alkaloid formation" EXACT []
synonym: "benzyl isoquinoline alkaloid synthesis" EXACT []
is_a: GO:0033075 ! isoquinoline alkaloid biosynthetic process
is_a: GO:0046445 ! benzyl isoquinoline alkaloid metabolic process

[Term]
id: GO:0009709
name: terpenoid indole alkaloid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of terpenoid indole alkaloids, compounds formed from the condensation of tryptamine (derived from tryptophan) and secologanin (derived from geranyl pyrophosphate)." [GOC:ai, http://rycomusa.com/aspp2000/public/P29/0525.html]
subset: gosubset_prok
synonym: "terpenoid indole alkaloid anabolism" EXACT []
synonym: "terpenoid indole alkaloid biosynthesis" EXACT []
synonym: "terpenoid indole alkaloid formation" EXACT []
synonym: "terpenoid indole alkaloid synthesis" EXACT []
is_a: GO:0035835 ! indole alkaloid biosynthetic process
is_a: GO:0046447 ! terpenoid indole alkaloid metabolic process

[Term]
id: GO:0009710
name: tropane alkaloid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tropane alkaloids, compounds containing the 8-methyl-8-azabicyclo(3.2.1)octane ring system." [GOC:ai, ISBN:0198506732]
subset: gosubset_prok
synonym: "tropane alkaloid anabolism" EXACT []
synonym: "tropane alkaloid biosynthesis" EXACT []
synonym: "tropane alkaloid formation" EXACT []
synonym: "tropane alkaloid synthesis" EXACT []
is_a: GO:0009821 ! alkaloid biosynthetic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0046448 ! tropane alkaloid metabolic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process

[Term]
id: GO:0009711
name: purine alkaloid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of purine alkaloids, compounds derived from purine and composed of an N-containing double ring structure." [GOC:ai]
subset: gosubset_prok
synonym: "purine alkaloid anabolism" EXACT []
synonym: "purine alkaloid biosynthesis" EXACT []
synonym: "purine alkaloid formation" EXACT []
synonym: "purine alkaloid synthesis" EXACT []
is_a: GO:0009821 ! alkaloid biosynthetic process
is_a: GO:0046446 ! purine alkaloid metabolic process
is_a: GO:0072522 ! purine-containing compound biosynthetic process

[Term]
id: GO:0009712
name: catechol-containing compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a compound containing a pyrocatechol (1,2-benzenediol) nucleus or substituent." [GOC:sm, ISBN:0198547684]
subset: gosubset_prok
synonym: "catechol metabolic process" RELATED []
synonym: "catechol metabolism" RELATED []
is_a: GO:0018958 ! phenol-containing compound metabolic process

[Term]
id: GO:0009713
name: catechol-containing compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent." [GOC:go_curators]
subset: gosubset_prok
synonym: "catechol anabolism" RELATED []
synonym: "catechol biosynthesis" RELATED []
synonym: "catechol biosynthetic process" RELATED []
synonym: "catechol formation" RELATED []
synonym: "catechol synthesis" RELATED []
is_a: GO:0009712 ! catechol-containing compound metabolic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process

[Term]
id: GO:0009714
name: chalcone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving chalcones, phenyl steryl ketone or its hydroxylated derivatives." [ISBN:0198506732]
subset: gosubset_prok
synonym: "chalcone metabolism" EXACT []
is_a: GO:0009698 ! phenylpropanoid metabolic process
is_a: GO:0042180 ! cellular ketone metabolic process

[Term]
id: GO:0009715
name: chalcone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of chalcone, phenyl steryl ketone or its hydroxylated derivatives." [GOC:go_curators]
subset: gosubset_prok
synonym: "chalcone anabolism" EXACT []
synonym: "chalcone biosynthesis" EXACT []
synonym: "chalcone formation" EXACT []
synonym: "chalcone synthesis" EXACT []
is_a: GO:0009699 ! phenylpropanoid biosynthetic process
is_a: GO:0009714 ! chalcone metabolic process
is_a: GO:0042181 ! ketone biosynthetic process

[Term]
id: GO:0009716
name: flavonoid phytoalexin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of flavonoid phytoalexins, a group of water-soluble phenolic derivatives containing a flavan skeleton, which possess antibiotic activity and are produced by plant tissues in response to infection." [ISBN:0198506732]
subset: gosubset_prok
synonym: "flavonoid phytoalexin anabolism" EXACT []
synonym: "flavonoid phytoalexin biosynthesis" EXACT []
synonym: "flavonoid phytoalexin formation" EXACT []
synonym: "flavonoid phytoalexin synthesis" EXACT []
is_a: GO:0009813 ! flavonoid biosynthetic process
is_a: GO:0046285 ! flavonoid phytoalexin metabolic process
is_a: GO:0052315 ! phytoalexin biosynthetic process

[Term]
id: GO:0009717
name: isoflavonoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of isoflavonoids, a group of water-soluble phenolic derivatives, isomeric with flavonoids." [GOC:ai]
subset: gosubset_prok
synonym: "isoflavonoid anabolism" EXACT []
synonym: "isoflavonoid biosynthesis" EXACT []
synonym: "isoflavonoid formation" EXACT []
synonym: "isoflavonoid synthesis" EXACT []
is_a: GO:0009699 ! phenylpropanoid biosynthetic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0046287 ! isoflavonoid metabolic process

[Term]
id: GO:0009718
name: anthocyanin-containing compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins." [GOC:ai]
subset: gosubset_prok
synonym: "anthocyanin anabolism" EXACT []
synonym: "anthocyanin biosynthesis" EXACT []
synonym: "anthocyanin biosynthetic process" EXACT []
synonym: "anthocyanin formation" EXACT []
synonym: "anthocyanin synthesis" EXACT []
is_a: GO:0009813 ! flavonoid biosynthetic process
is_a: GO:0046148 ! pigment biosynthetic process
is_a: GO:0046283 ! anthocyanin-containing compound metabolic process

[Term]
id: GO:0009719
name: response to endogenous stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:sm]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
subset: goslim_plant
subset: gosubset_prok
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0009720
name: detection of hormone stimulus
namespace: biological_process
def: "The series of events in which a hormone stimulus is received by a cell and converted into a molecular signal." [GOC:sm]
synonym: "perception of hormone stimulus" RELATED []
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0009725 ! response to hormone
is_a: GO:0009726 ! detection of endogenous stimulus

[Term]
id: GO:0009721
name: detection of auxin stimulus
namespace: biological_process
def: "The series of events in which an auxin stimulus is received by a cell and converted into a molecular signal." [GOC:sm]
synonym: "perception of auxin stimulus" RELATED []
is_a: GO:0009720 ! detection of hormone stimulus
is_a: GO:0009733 ! response to auxin

[Term]
id: GO:0009722
name: detection of cytokinin stimulus
namespace: biological_process
def: "The series of events in which a cytokinin stimulus is received by a cell and converted into a molecular signal." [GOC:sm]
synonym: "perception of cytokinin stimulus" RELATED []
is_a: GO:0009720 ! detection of hormone stimulus
is_a: GO:0009735 ! response to cytokinin

[Term]
id: GO:0009723
name: response to ethylene
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethylene (ethene) stimulus." [GOC:jl]
synonym: "response to ethene stimulus" EXACT []
synonym: "response to ethylene stimulus" EXACT []
is_a: GO:0009725 ! response to hormone

[Term]
id: GO:0009724
name: detection of abscisic acid stimulus
namespace: biological_process
def: "The series of events in which an abscisic acid stimulus is received by a cell and converted into a molecular signal." [GOC:sm]
synonym: "perception of abscisic acid stimulus" RELATED []
is_a: GO:0009720 ! detection of hormone stimulus
is_a: GO:0009737 ! response to abscisic acid

[Term]
id: GO:0009725
name: response to hormone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:jl]
synonym: "growth regulator" RELATED []
synonym: "response to hormone stimulus" EXACT [GOC:dos]
is_a: GO:0009719 ! response to endogenous stimulus
is_a: GO:0010033 ! response to organic substance

[Term]
id: GO:0009726
name: detection of endogenous stimulus
namespace: biological_process
def: "The series of events in which an endogenous stimulus is received by a cell and converted into a molecular signal." [GOC:sm]
synonym: "perception of endogenous stimulus" RELATED []
is_a: GO:0009719 ! response to endogenous stimulus
is_a: GO:0051606 ! detection of stimulus

[Term]
id: GO:0009727
name: detection of ethylene stimulus
namespace: biological_process
def: "The series of events in which an ethylene (ethene) stimulus is received by a cell and converted into a molecular signal." [GOC:sm]
synonym: "detection of ethene stimulus" EXACT []
synonym: "perception of ethene stimulus" RELATED []
synonym: "perception of ethylene stimulus" RELATED []
is_a: GO:0009720 ! detection of hormone stimulus
is_a: GO:0009723 ! response to ethylene

[Term]
id: GO:0009728
name: detection of gibberellic acid stimulus
namespace: biological_process
def: "The series of events in which a gibberellic acid stimulus is received by a cell and converted into a molecular signal." [GOC:sm]
synonym: "perception of gibberellic acid stimulus" RELATED []
is_a: GO:0009720 ! detection of hormone stimulus
is_a: GO:0009739 ! response to gibberellin

[Term]
id: GO:0009729
name: detection of brassinosteroid stimulus
namespace: biological_process
def: "The series of events in which a brassinosteroid stimulus is received by a cell and converted into a molecular signal." [GOC:sm]
synonym: "perception of brassinosteroid stimulus" RELATED []
is_a: GO:0009720 ! detection of hormone stimulus
is_a: GO:0009741 ! response to brassinosteroid

[Term]
id: GO:0009730
name: detection of carbohydrate stimulus
namespace: biological_process
def: "The series of events in which a carbohydrate stimulus is received by a cell and converted into a molecular signal." [GOC:sm]
synonym: "perception of carbohydrate stimulus" RELATED []
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0009743 ! response to carbohydrate

[Term]
id: GO:0009731
name: detection of sucrose stimulus
namespace: biological_process
def: "The series of events in which a sucrose stimulus is received by a cell and converted into a molecular signal." [GOC:sm]
synonym: "perception of sucrose stimulus" RELATED []
is_a: GO:0009744 ! response to sucrose
is_a: GO:0034288 ! detection of disaccharide stimulus

[Term]
id: GO:0009732
name: detection of hexose stimulus
namespace: biological_process
def: "The series of events in which a stimulus from a hexose is received and converted into a molecular signal." [GOC:sm]
synonym: "perception of hexose stimulus" RELATED []
is_a: GO:0009746 ! response to hexose
is_a: GO:0034287 ! detection of monosaccharide stimulus

[Term]
id: GO:0009733
name: response to auxin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auxin stimulus." [GOC:jl]
synonym: "response to auxin stimulus" EXACT [GOC:dos]
is_a: GO:0009725 ! response to hormone

[Term]
id: GO:0009734
name: auxin-activated signaling pathway
namespace: biological_process
def: "A series of molecular signals generated by the binding of the plant hormone auxin to a receptor, and ending with modulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:sm, PMID:16990790, PMID:18647826]
synonym: "auxin mediated signaling pathway" RELATED []
synonym: "auxin mediated signalling" EXACT []
synonym: "auxin signal transduction" EXACT [PMID:16990790]
synonym: "auxin signaling" EXACT [PMID:18647826]
synonym: "auxin-regulated transcription" RELATED [PMID:15917797]
is_a: GO:0009755 ! hormone-mediated signaling pathway
relationship: part_of GO:0071365 ! cellular response to auxin stimulus

[Term]
id: GO:0009735
name: response to cytokinin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokinin stimulus." [GOC:jl]
synonym: "response to cytokinin stimulus" EXACT [GOC:dos]
is_a: GO:0009725 ! response to hormone

[Term]
id: GO:0009736
name: cytokinin-activated signaling pathway
namespace: biological_process
def: "A series of molecular signals generated by the binding of a cytokinin to a receptor, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:sm, PMID:24080474]
synonym: "cytokinin mediated signaling pathway" RELATED []
synonym: "cytokinin mediated signalling" EXACT []
synonym: "cytokinin signaling" EXACT [PMID:24080474]
is_a: GO:0009755 ! hormone-mediated signaling pathway
relationship: part_of GO:0071368 ! cellular response to cytokinin stimulus

[Term]
id: GO:0009737
name: response to abscisic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus." [GOC:jl]
synonym: "response to abscisic acid stimulus" EXACT [GOC:dos]
is_a: GO:0001101 ! response to acid chemical
is_a: GO:0009725 ! response to hormone
is_a: GO:0033993 ! response to lipid
is_a: GO:0097305 ! response to alcohol

[Term]
id: GO:0009738
name: abscisic acid-activated signaling pathway
namespace: biological_process
def: "A series of molecular signals generated by the binding of the plant hormone abscisic acid (ABA) to a receptor, and ending with modulation of a cellular process, e.g. transcription." [GOC:signaling, GOC:sm, PMID:24269821]
synonym: "ABA signal transduction" EXACT [PMID:20713515]
synonym: "ABA signaling" EXACT [PMID:24269821]
synonym: "abscisic acid mediated signalling" EXACT []
synonym: "abscisic acid signal transduction" RELATED [PMID:20713515]
synonym: "abscisic acid-mediated signaling pathway" RELATED []
is_a: GO:0009755 ! hormone-mediated signaling pathway
relationship: part_of GO:0071215 ! cellular response to abscisic acid stimulus

[Term]
id: GO:0009739
name: response to gibberellin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gibberellin stimulus." [GOC:jl]
synonym: "response to gibberellic acid stimulus" NARROW []
synonym: "response to gibberellin stimulus" EXACT [GOC:dos]
is_a: GO:0001101 ! response to acid chemical
is_a: GO:0009725 ! response to hormone
is_a: GO:0033993 ! response to lipid
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0009740
name: gibberellic acid mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals mediated by the detection of gibberellic acid." [GOC:sm]
synonym: "GA-signaling" EXACT []
synonym: "gibberellic acid mediated signalling" EXACT []
synonym: "gibberellic acid signaling" EXACT []
is_a: GO:0010476 ! gibberellin mediated signaling pathway

[Term]
id: GO:0009741
name: response to brassinosteroid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brassinosteroid stimulus." [GOC:jl]
synonym: "response to brassinosteroid stimulus" EXACT [GOC:dos]
is_a: GO:0009725 ! response to hormone
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033993 ! response to lipid
is_a: GO:0097305 ! response to alcohol

[Term]
id: GO:0009742
name: brassinosteroid mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals mediated by the detection of brassinosteroid." [GOC:sm]
synonym: "brassinosteroid mediated signalling" EXACT []
is_a: GO:0043401 ! steroid hormone mediated signaling pathway
relationship: part_of GO:0071367 ! cellular response to brassinosteroid stimulus

[Term]
id: GO:0009743
name: response to carbohydrate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus." [GOC:jl]
synonym: "response to carbohydrate stimulus" EXACT [GOC:dos]
is_a: GO:0010033 ! response to organic substance
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0009744
name: response to sucrose
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus." [GOC:jl]
synonym: "response to sucrose stimulus" EXACT [GOC:dos]
is_a: GO:0034285 ! response to disaccharide

[Term]
id: GO:0009745
name: sucrose mediated signaling
namespace: biological_process
def: "A series of molecular signals mediated by the detection of sucrose." [GOC:sm]
synonym: "sucrose mediated signalling" EXACT []
is_a: GO:0010182 ! sugar mediated signaling pathway
relationship: part_of GO:0071329 ! cellular response to sucrose stimulus

[Term]
id: GO:0009746
name: response to hexose
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus." [GOC:jl]
synonym: "response to hexose stimulus" EXACT [GOC:dos]
is_a: GO:0034284 ! response to monosaccharide

[Term]
id: GO:0009747
name: hexokinase-dependent signaling
namespace: biological_process
def: "A series of molecular signals mediated by hexose and dependent on the detection of hexokinase." [GOC:mah, GOC:sm]
synonym: "hexokinase-dependent signalling" EXACT []
is_a: GO:0009757 ! hexose mediated signaling

[Term]
id: GO:0009748
name: hexokinase-independent signaling
namespace: biological_process
def: "A series of molecular signals mediated by hexose and independent of hexokinase." [GOC:mah, GOC:sm]
synonym: "hexokinase-independent signalling" EXACT []
is_a: GO:0009757 ! hexose mediated signaling

[Term]
id: GO:0009749
name: response to glucose
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus." [GOC:jl]
synonym: "response to glucose stimulus" EXACT [GOC:dos]
is_a: GO:0009746 ! response to hexose

[Term]
id: GO:0009750
name: response to fructose
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fructose stimulus." [GOC:jl]
synonym: "response to fructose stimulus" EXACT [GOC:dos]
is_a: GO:0009746 ! response to hexose

[Term]
id: GO:0009751
name: response to salicylic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salicylic acid stimulus." [GOC:jl]
synonym: "response to salicylate" EXACT [GOC:dph]
synonym: "response to salicylic acid stimulus" EXACT [GOC:dos]
is_a: GO:0001101 ! response to acid chemical
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0009752
name: detection of salicylic acid stimulus
namespace: biological_process
def: "The series of events in which a salicylic acid stimulus is received by a cell and converted into a molecular signal." [GOC:sm]
synonym: "perception of salicylic acid stimulus" RELATED []
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0009751 ! response to salicylic acid

[Term]
id: GO:0009753
name: response to jasmonic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus." [GOC:jl]
synonym: "response to jasmonic acid stimulus" EXACT [GOC:dos]
is_a: GO:0001101 ! response to acid chemical
is_a: GO:0009725 ! response to hormone
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0009754
name: detection of jasmonic acid stimulus
namespace: biological_process
def: "The series of events in which a jasmonic acid stimulus is received by a cell and converted into a molecular signal. Series of events required for a jasmonic acid stimulus to be detected and converted to a signal molecule." [GOC:sm]
synonym: "perception of jasmonic acid stimulus" RELATED []
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0009726 ! detection of endogenous stimulus
is_a: GO:0009753 ! response to jasmonic acid

[Term]
id: GO:0009755
name: hormone-mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals mediated by the detection of a hormone." [GOC:sm]
synonym: "hormone mediated signalling" EXACT []
is_a: GO:0007165 ! signal transduction
relationship: part_of GO:0032870 ! cellular response to hormone stimulus

[Term]
id: GO:0009756
name: carbohydrate mediated signaling
namespace: biological_process
def: "A series of molecular signals mediated by the detection of carbohydrate." [GOC:sm]
synonym: "carbohydrate mediated signalling" EXACT []
is_a: GO:0007165 ! signal transduction
relationship: part_of GO:0071322 ! cellular response to carbohydrate stimulus

[Term]
id: GO:0009757
name: hexose mediated signaling
namespace: biological_process
def: "A series of molecular signals mediated by the detection of hexose." [GOC:sm]
synonym: "hexose mediated signalling" EXACT []
is_a: GO:0010182 ! sugar mediated signaling pathway
relationship: part_of GO:0071331 ! cellular response to hexose stimulus

[Term]
id: GO:0009758
name: carbohydrate utilization
namespace: biological_process
alt_id: GO:0007587
def: "A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbohydrate sources,usually glucose, and then activates genes to scavenge the last traces of the primary carbohydrate source and to transport and metabolize alternate carbohydrate sources. The utilization process begins when the cell or organism detects carbohydrate levels, includes the activation of genes whose products detect, transport or metabolize carbohydrates, and ends when the carbohydrate is incorporated into the cell or organism's metabolism." [GOC:mah, GOC:mcc2, GOC:mlg]
synonym: "sugar utilization" NARROW [GOC:mcc2]
is_a: GO:0044699 ! single-organism process
relationship: has_part GO:0005975 ! carbohydrate metabolic process
relationship: has_part GO:0008643 ! carbohydrate transport
relationship: has_part GO:0009730 ! detection of carbohydrate stimulus

[Term]
id: GO:0009759
name: indole glucosinolate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of indole glucosinolates, sulfur-containing compounds that have a common structure linked to an R group derived from tryptophan." [GOC:ai]
subset: gosubset_prok
synonym: "indole glucosinolate anabolism" EXACT []
synonym: "indole glucosinolate biosynthesis" EXACT []
synonym: "indole glucosinolate formation" EXACT []
synonym: "indole glucosinolate synthesis" EXACT []
xref: MetaCyc:PWY-601
is_a: GO:0019761 ! glucosinolate biosynthetic process
is_a: GO:0042343 ! indole glucosinolate metabolic process
is_a: GO:0042435 ! indole-containing compound biosynthetic process

[Term]
id: GO:0009760
name: C4 photosynthesis
namespace: biological_process
def: "The combination of atmospheric CO2 with a 3-carbon molecule phosphoenol pyruvate (PEP) in the mesophyll cells to make a 4-carbon acid which is immediately converted to malic acid. The malic acid is then passed across to the bundle sheath cells where it is broken down again to pyruvic acid and CO2. The acid is passed back to the mesophyll cells to be used again, while the CO2 is fed into the reductive pentose-phosphate cycle (Calvin cycle) and converted into sugar and starch." [ISBN:0816017360]
xref: Wikipedia:C4_carbon_fixation
is_a: GO:0015977 ! carbon fixation
is_a: GO:0019685 ! photosynthesis, dark reaction
is_a: GO:0044236 ! multicellular organism metabolic process

[Term]
id: GO:0009761
name: CAM photosynthesis
namespace: biological_process
def: "The combination of atmospheric CO2 with a 3-carbon molecule phosphoenol pyruvate (PEP) to make malic acid. The malic acid is then passed into the vacuole where it is stored until daylight, when it is shuttled back out to be used as a substrate in the light reaction of photosynthesis." [ISBN:0582015952]
xref: Wikipedia:Crassulacean_acid_metabolism
is_a: GO:0015977 ! carbon fixation
is_a: GO:0019685 ! photosynthesis, dark reaction

[Term]
id: GO:0009762
name: NADP-malic enzyme C4 photosynthesis
namespace: biological_process
def: "The process of C4 photosynthesis, as it occurs in plants in which the enzyme decarboxylating C4 acids in the bundle sheath is NADP-malic enzyme." [PMID:11788762]
xref: MetaCyc:PWY-241
is_a: GO:0009760 ! C4 photosynthesis

[Term]
id: GO:0009763
name: NAD-malic enzyme C4 photosynthesis
namespace: biological_process
def: "The process of C4 photosynthesis, as it occurs in plants in which the enzyme decarboxylating C4 acids in the bundle sheath is NAD-malic enzyme." [PMID:11788762]
is_a: GO:0009760 ! C4 photosynthesis

[Term]
id: GO:0009764
name: PEP carboxykinase C4 photosynthesis
namespace: biological_process
def: "The process of C4 photosynthesis, as it occurs in plants in which the enzyme decarboxylating C4 acids in the bundle sheath is phosphoenolpyruvate carboxykinase (PEPCK)." [PMID:11788762]
is_a: GO:0009760 ! C4 photosynthesis

[Term]
id: GO:0009765
name: photosynthesis, light harvesting
namespace: biological_process
def: "Absorption and transfer of the energy absorbed from light photons between photosystem reaction centers." [GOC:sm]
synonym: "energy dissipation" RELATED []
is_a: GO:0006091 ! generation of precursor metabolites and energy
relationship: part_of GO:0019684 ! photosynthesis, light reaction

[Term]
id: GO:0009766
name: primary charge separation
namespace: biological_process
def: "In the photosynthetic reaction centers, primary charge separation is initiated by the excitation of a molecule followed by the transfer of an electron to an electron acceptor molecule following energy transfer from light harvesting complexes." [ISBN:0792361431]
is_a: GO:0022904 ! respiratory electron transport chain
relationship: part_of GO:0019684 ! photosynthesis, light reaction

[Term]
id: GO:0009767
name: photosynthetic electron transport chain
namespace: biological_process
alt_id: GO:0009774
alt_id: GO:0009775
alt_id: GO:0009776
def: "A process, occurring as part of photosynthesis, in which light provides the energy for a series of electron carriers to operate together to transfer electrons and generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport, ISBN:0198547684]
synonym: "electron carrier, chlorophyll electron transport system" EXACT []
synonym: "photosynthetic electron transport in cytochrome b6/f" NARROW []
synonym: "photosynthetic electron transport in plastocyanin" NARROW []
synonym: "photosynthetic electron transport in plastoquinone" NARROW []
is_a: GO:0022900 ! electron transport chain
relationship: part_of GO:0019684 ! photosynthesis, light reaction

[Term]
id: GO:0009768
name: photosynthesis, light harvesting in photosystem I
namespace: biological_process
def: "After a photon of light is absorbed by one of the many chlorophyll molecules, in one of the light-harvesting complexes of an antenna on photosystem I, some of the absorbed energy is transferred to the pair of chlorophyll molecules in the reaction center." [GOC:jid, ISBN:0716731363, ISBN:0816017360]
is_a: GO:0009765 ! photosynthesis, light harvesting

[Term]
id: GO:0009769
name: photosynthesis, light harvesting in photosystem II
namespace: biological_process
def: "After a photon of light is absorbed by one of the many chlorophyll molecules, in one of the light-harvesting complexes of an antenna on photosystem II, some of the absorbed energy is transferred to the pair of chlorophyll molecules in the reaction center." [GOC:jid, ISBN:0716731363, ISBN:0816017360]
is_a: GO:0009765 ! photosynthesis, light harvesting

[Term]
id: GO:0009770
name: primary charge separation in photosystem I
namespace: biological_process
def: "Energized reaction-center P700 chlorophylls on photosystem I donate an electron to a loosely bound Quinone acceptor molecule X, on the stromal surface of the thylakoid membrane. The result is charge separation; a negative charge on the stromal side of the thylakoid membrane and a positive charge on the luminal side." [GOC:jid, ISBN:0716731363, ISBN:0816017360]
is_a: GO:0009766 ! primary charge separation

[Term]
id: GO:0009771
name: primary charge separation in photosystem II
namespace: biological_process
def: "Energized reaction-center P680 chlorophylls on photosystem II donate an electron to a loosely bound acceptor molecule, the quinone Q, on the stromal surface of the thylakoid membrane. The result is charge separation; a negative charge on the stromal side of the thylakoid membrane and a positive charge on the luminal side." [GOC:jid, ISBN:0716731363, ISBN:0816017360]
is_a: GO:0009766 ! primary charge separation

[Term]
id: GO:0009772
name: photosynthetic electron transport in photosystem II
namespace: biological_process
def: "A photosynthetic electron transport chain in which electrons move from the primary electron acceptor (Quinone, Q) through a chain of electron transport molecules in the thylakoid membrane until they reach the ultimate electron acceptor of Photosystem II, which is plastocyanin (PC). The electron is then passed to the P700 chlorophyll a molecules of the reaction centre of photosystem I." [GOC:jid, ISBN:0716731363, ISBN:0816017360]
is_a: GO:0009767 ! photosynthetic electron transport chain

[Term]
id: GO:0009773
name: photosynthetic electron transport in photosystem I
namespace: biological_process
def: "A photosynthetic electron transport chain in which electrons move from the primary electron acceptor (Quinone, X) through a chain of electron transport molecules in the thylakoid membrane until they reach ferredoxin which passes the electron to the ultimate electron acceptor; NADP." [GOC:jid, ISBN:0716731363, ISBN:0816017360]
is_a: GO:0009767 ! photosynthetic electron transport chain

[Term]
id: GO:0009777
name: photosynthetic phosphorylation
namespace: biological_process
def: "Any metabolic process in which photosynthetic organisms use light energy to convert ADP to ATP without the concomitant reduction of dioxygen (O2) to water that occurs in phosphorylation." [ISBN:0198547684]
synonym: "photosynthetic ATP synthesis" NARROW []
is_a: GO:0016310 ! phosphorylation
is_a: GO:0046034 ! ATP metabolic process
relationship: has_part GO:0015986 ! ATP synthesis coupled proton transport
relationship: part_of GO:0019684 ! photosynthesis, light reaction

[Term]
id: GO:0009778
name: cyclic photosynthetic phosphorylation
namespace: biological_process
def: "A photosynthetic phosphorylation process in which ATP synthesis is driven by a proton gradient generated across the thylakoid membrane. Involves only photosystem I." [ISBN:0198547684]
is_a: GO:0009777 ! photosynthetic phosphorylation

[Term]
id: GO:0009779
name: noncyclic photosynthetic phosphorylation
namespace: biological_process
def: "A photosynthetic phosphorylation process in which ATP synthesis is linked to the transport of electrons from water to NADP+ with the production of NADPH and dioxygen (O2). Involves photosystem I and photosystem II." [ISBN:0198547684]
is_a: GO:0009777 ! photosynthetic phosphorylation

[Term]
id: GO:0009780
name: photosynthetic NADP+ reduction
namespace: biological_process
def: "An NADPH regeneration process that contributes to the light reactions of photosynthesis. The light reactions of photosynthesis use energy from photons to generate high-energy electrons. These electrons are used directly to reduce NADP+ to NADPH. NADPH is a relatively stable molecule and can pass on its hydrogen atom to other molecules in chemical reactions." [GOC:jid, ISBN:0716746840, ISBN:0816017360]
is_a: GO:0006740 ! NADPH regeneration
relationship: part_of GO:0019684 ! photosynthesis, light reaction

[Term]
id: GO:0009781
name: obsolete photosynthetic water oxidation
namespace: biological_process
def: "OBSOLETE. Processes by which a molecule of water is oxidized during photosynthesis. P680+, the photochemically oxidized reaction-center chlorophyll of PSII, is a strong biological oxidant. The reduction potential of P680+ is more positive than that of water, and thus it can oxidize water to give O2 and H+ ions. The oxygen escapes as a gas while the H+ ions remain in solution inside the thylakoid vesicle." [GOC:jid, ISBN:0716743663, ISBN:0816017360]
comment: This term was made obsolete because it represents a molecular function.
synonym: "photosynthetic water oxidation" EXACT []
is_obsolete: true
replaced_by: GO:0010242

[Term]
id: GO:0009782
name: photosystem I antenna complex
namespace: cellular_component
def: "The antenna complex of photosystem I. A photosystem has two closely linked components, an antenna containing light-absorbing pigments and a reaction center. Each antenna contains one or more light-harvesting complexes (LHCs)." [GOC:jid, ISBN:0716731363]
is_a: GO:0044436 ! thylakoid part
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0009522 ! photosystem I

[Term]
id: GO:0009783
name: photosystem II antenna complex
namespace: cellular_component
def: "The antenna complex of photosystem II. A photosystem has two closely linked components, an antenna containing light-absorbing pigments and a reaction center. Each antenna contains one or more light-harvesting complexes (LHCs)." [GOC:jid, ISBN:0716731363]
is_a: GO:0044436 ! thylakoid part
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0009523 ! photosystem II

[Term]
id: GO:0009784
name: transmembrane receptor histidine kinase activity
namespace: molecular_function
def: "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-histidine = ADP + a protein-L-histidine phosphate." [GOC:lr, GOC:mah]
subset: gosubset_prok
is_a: GO:0004673 ! protein histidine kinase activity
is_a: GO:0019199 ! transmembrane receptor protein kinase activity

[Term]
id: GO:0009785
name: blue light signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated upon sensing of blue light by photoreceptor molecule, at a wavelength between 400nm and 470nm." [GOC:lr, GOC:sm]
synonym: "blue light signalling pathway" EXACT []
is_a: GO:0030522 ! intracellular receptor signaling pathway
is_a: GO:0071483 ! cellular response to blue light

[Term]
id: GO:0009786
name: regulation of asymmetric cell division
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of asymmetric cell division." [GOC:lr]
is_a: GO:0051302 ! regulation of cell division
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008356 ! asymmetric cell division
relationship: regulates GO:0008356 ! asymmetric cell division

[Term]
id: GO:0009787
name: regulation of abscisic acid-activated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of abscisic acid (ABA) signaling." [GOC:lr]
synonym: "regulation of abscisic acid mediated signaling pathway" RELATED []
synonym: "regulation of abscisic acid mediated signalling" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:1901419 ! regulation of response to alcohol
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009738 ! abscisic acid-activated signaling pathway
relationship: regulates GO:0009738 ! abscisic acid-activated signaling pathway

[Term]
id: GO:0009788
name: negative regulation of abscisic acid-activated signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of abscisic acid (ABA) signaling." [GOC:lr]
synonym: "down regulation of abscisic acid mediated signaling" EXACT []
synonym: "down-regulation of abscisic acid mediated signaling" EXACT []
synonym: "downregulation of abscisic acid mediated signaling" EXACT []
synonym: "inhibition of abscisic acid mediated signaling" NARROW []
synonym: "negative regulation of abscisic acid mediated signaling pathway" RELATED []
synonym: "negative regulation of abscisic acid mediated signalling" EXACT []
is_a: GO:0009787 ! regulation of abscisic acid-activated signaling pathway
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:1901420 ! negative regulation of response to alcohol
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009738 ! abscisic acid-activated signaling pathway
relationship: negatively_regulates GO:0009738 ! abscisic acid-activated signaling pathway

[Term]
id: GO:0009789
name: positive regulation of abscisic acid-activated signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of abscisic acid (ABA) signaling." [GOC:lr]
synonym: "activation of abscisic acid mediated signaling" NARROW []
synonym: "positive regulation of abscisic acid mediated signaling pathway" RELATED []
synonym: "positive regulation of abscisic acid mediated signalling" EXACT []
synonym: "stimulation of abscisic acid mediated signaling" NARROW []
synonym: "up regulation of abscisic acid mediated signaling" EXACT []
synonym: "up-regulation of abscisic acid mediated signaling" EXACT []
synonym: "upregulation of abscisic acid mediated signaling" EXACT []
is_a: GO:0009787 ! regulation of abscisic acid-activated signaling pathway
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:1901421 ! positive regulation of response to alcohol
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009738 ! abscisic acid-activated signaling pathway
relationship: positively_regulates GO:0009738 ! abscisic acid-activated signaling pathway

[Term]
id: GO:0009790
name: embryo development
namespace: biological_process
alt_id: GO:0009795
def: "The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]
subset: gocheck_do_not_manually_annotate
subset: goslim_chembl
subset: goslim_generic
subset: goslim_plant
synonym: "embryogenesis" EXACT []
synonym: "embryogenesis and morphogenesis" BROAD []
synonym: "embryonal development" EXACT []
xref: Wikipedia:Embryogenesis
is_a: GO:0007275 ! multicellular organism development

[Term]
id: GO:0009791
name: post-embryonic development
namespace: biological_process
def: "The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development." [GOC:go_curators]
subset: goslim_plant
is_a: GO:0044707 ! single-multicellular organism process
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0007275 ! multicellular organism development

[Term]
id: GO:0009792
name: embryo development ending in birth or egg hatching
namespace: biological_process
def: "The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]
synonym: "embryogenesis" BROAD []
is_a: GO:0009790 ! embryo development

[Term]
id: GO:0009793
name: embryo development ending in seed dormancy
namespace: biological_process
def: "The process whose specific outcome is the progression of the embryo over time, from zygote formation to the end of seed dormancy. An example of this process is found in Arabidopsis thaliana." [GOC:go_curators, GOC:mtg_sensu]
synonym: "embryogenesis" BROAD []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0009790 ! embryo development
is_a: GO:0044702 ! single organism reproductive process
relationship: part_of GO:0048316 ! seed development

[Term]
id: GO:0009794
name: regulation of mitotic cell cycle, embryonic
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of replication and segregation of genetic material in the embryo." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "embryonic mitotic cell cycle modulation" EXACT []
synonym: "embryonic mitotic cell cycle regulation" EXACT []
synonym: "embryonic mitotic cell cycle regulator" RELATED []
synonym: "modulation of embryonic mitotic cell cycle progression" EXACT []
synonym: "regulation of embryonic mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of embryonic mitotic cell cycle progression" EXACT []
synonym: "regulation of progression through embryonic mitotic cell cycle" EXACT []
is_a: GO:0007346 ! regulation of mitotic cell cycle
is_a: GO:0045995 ! regulation of embryonic development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045448 ! mitotic cell cycle, embryonic
relationship: regulates GO:0045448 ! mitotic cell cycle, embryonic

[Term]
id: GO:0009798
name: axis specification
namespace: biological_process
def: "The establishment, maintenance and elaboration of a pattern along a line or around a point." [GOC:dph, GOC:go_curators, GOC:isa_complete]
synonym: "axis determination" RELATED []
is_a: GO:0007389 ! pattern specification process

[Term]
id: GO:0009799
name: specification of symmetry
namespace: biological_process
def: "The establishment of an organism's body plan or part of an organism such that a similar arrangement in form and relationship of parts around a common axis, or around each side of a plane is created." [GOC:go_curators]
synonym: "determination of symmetry" EXACT [GOC:dph]
is_a: GO:0007389 ! pattern specification process

[Term]
id: GO:0009800
name: cinnamic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid." [GOC:jl]
subset: gosubset_prok
synonym: "cinnamic acid anabolism" EXACT []
synonym: "cinnamic acid biosynthesis" EXACT []
synonym: "cinnamic acid formation" EXACT []
synonym: "cinnamic acid synthesis" EXACT []
synonym: "cinnamylic acid biosynthesis" EXACT []
synonym: "cinnamylic acid biosynthetic process" EXACT []
synonym: "phenylacrylic acid biosynthesis" EXACT []
synonym: "phenylacrylic acid biosynthetic process" EXACT []
synonym: "phenylpropenoic acid biosynthesis" EXACT []
synonym: "phenylpropenoic acid biosynthetic process" EXACT []
is_a: GO:0009699 ! phenylpropanoid biosynthetic process
is_a: GO:0009803 ! cinnamic acid metabolic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process

[Term]
id: GO:0009801
name: cinnamic acid ester metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ester derivatives of cinnamic acid, phenylpropenoic acid." [GOC:lr, GOC:yl]
subset: gosubset_prok
synonym: "cinnamic acid ester metabolism" EXACT []
is_a: GO:0009698 ! phenylpropanoid metabolic process

[Term]
id: GO:0009802
name: cinnamic acid ester biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ester derivatives of cinnamic acid, phenylpropenoic acid." [GOC:jl]
subset: gosubset_prok
synonym: "cinnamic acid ester anabolism" EXACT []
synonym: "cinnamic acid ester biosynthesis" EXACT []
synonym: "cinnamic acid ester formation" EXACT []
synonym: "cinnamic acid ester synthesis" EXACT []
synonym: "cinnamylic acid ester biosynthesis" EXACT []
synonym: "cinnamylic acid ester biosynthetic process" EXACT []
synonym: "phenylacrylic acid ester biosynthesis" EXACT []
synonym: "phenylacrylic acid ester biosynthetic process" EXACT []
is_a: GO:0009699 ! phenylpropanoid biosynthetic process
is_a: GO:0009801 ! cinnamic acid ester metabolic process
relationship: part_of GO:0009803 ! cinnamic acid metabolic process

[Term]
id: GO:0009803
name: cinnamic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cinnamic acid, 3-phenyl-2-propenoic acid." [GOC:jl]
subset: gosubset_prok
synonym: "cinnamic acid metabolism" EXACT []
synonym: "cinnamylic acid metabolic process" EXACT []
synonym: "cinnamylic acid metabolism" EXACT []
synonym: "phenylacrylic acid metabolic process" EXACT []
synonym: "phenylacrylic acid metabolism" EXACT []
synonym: "phenylpropenoic acid metabolic process" EXACT []
synonym: "phenylpropenoic acid metabolism" EXACT []
is_a: GO:0009698 ! phenylpropanoid metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:0009804
name: coumarin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving coumarins, compounds derived from the phenylacrylic skeleton of cinnamic acids." [GOC:lr, GOC:yl]
subset: gosubset_prok
synonym: "coumarin metabolism" EXACT []
xref: Reactome:REACT_112622 "Coumarin is 7-hydroxylated by CYP2A6, Xenopus tropicalis"
xref: Reactome:REACT_112822 "Coumarin is 7-hydroxylated by CYP2A6, Danio rerio"
xref: Reactome:REACT_113359 "Coumarin is 7-hydroxylated by CYP2A6, Mus musculus"
xref: Reactome:REACT_113450 "Coumarin is 7-hydroxylated by CYP2A6, Rattus norvegicus"
xref: Reactome:REACT_13492 "Coumarin is 7-hydroxylated by CYP2A13, Homo sapiens"
xref: Reactome:REACT_572 "Coumarin is 7-hydroxylated by CYP2A6, Homo sapiens"
xref: Reactome:REACT_80565 "Coumarin is 7-hydroxylated by CYP2A13, Rattus norvegicus"
xref: Reactome:REACT_83154 "Coumarin is 7-hydroxylated by CYP2A13, Xenopus tropicalis"
xref: Reactome:REACT_83496 "Coumarin is 7-hydroxylated by CYP2A13, Mus musculus"
xref: Reactome:REACT_91477 "Coumarin is 7-hydroxylated by CYP2A13, Danio rerio"
is_a: GO:0009698 ! phenylpropanoid metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0009805
name: coumarin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of coumarins, a class of compounds derived from the phenylacrylic skeleton of cinnamic acids." [GOC:lr, GOC:yl]
subset: gosubset_prok
synonym: "coumarin anabolism" EXACT []
synonym: "coumarin biosynthesis" EXACT []
synonym: "coumarin formation" EXACT []
synonym: "coumarin synthesis" EXACT []
xref: MetaCyc:PWY-5176
is_a: GO:0009699 ! phenylpropanoid biosynthetic process
is_a: GO:0009804 ! coumarin metabolic process
is_a: GO:0018130 ! heterocycle biosynthetic process

[Term]
id: GO:0009806
name: lignan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lignans, any member of a class of plant metabolites related to lignins. Lignans are usually found as phenylpropanoid dimers in which the phenylpropanoid units are linked tail to tail and thus having a 2,3 dibenzylbutane skeleton, but higher oligomers can also exist." [GOC:jl, PMID:10074466]
subset: gosubset_prok
synonym: "lignan metabolism" EXACT []
is_a: GO:0009698 ! phenylpropanoid metabolic process

[Term]
id: GO:0009807
name: lignan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lignans, any member of a class of plant metabolites related to lignins. Lignans are usually found as phenylpropanoid dimers in which the phenylpropanoid units are linked tail to tail and thus having a 2,3 dibenzylbutane skeleton, but higher oligomers can also exist." [GOC:jl, PMID:10074466]
subset: gosubset_prok
synonym: "lignan anabolism" EXACT []
synonym: "lignan biosynthesis" EXACT []
synonym: "lignan formation" EXACT []
synonym: "lignan synthesis" EXACT []
is_a: GO:0009699 ! phenylpropanoid biosynthetic process
is_a: GO:0009806 ! lignan metabolic process

[Term]
id: GO:0009808
name: lignin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lignins, a class of polymers of phenylpropanoid units." [GOC:lr, GOC:yl]
subset: gosubset_prok
synonym: "lignin metabolism" EXACT []
is_a: GO:0009698 ! phenylpropanoid metabolic process

[Term]
id: GO:0009809
name: lignin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lignins, a class of polymers formed by the dehydrogenetive radical polymerization of various phenylpropanoid monomers." [GOC:tair_curators, ISBN:0198547684]
subset: gosubset_prok
synonym: "lignin anabolism" EXACT []
synonym: "lignin biosynthesis" EXACT []
synonym: "lignin formation" EXACT []
synonym: "lignin synthesis" EXACT []
xref: MetaCyc:PWY-361
is_a: GO:0009699 ! phenylpropanoid biosynthetic process
is_a: GO:0009808 ! lignin metabolic process

[Term]
id: GO:0009810
name: stilbene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving stilbenes, a class of polyketides formed from a molecule of cinnamic acid and three molecules of malonyl-CoA." [ISBN:311011625]
subset: gosubset_prok
synonym: "stilbene metabolism" EXACT []
is_a: GO:0009698 ! phenylpropanoid metabolic process
is_a: GO:1900673 ! olefin metabolic process

[Term]
id: GO:0009811
name: stilbene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of stilbenes, a class of polyketide compounds formed from cinnamic acid and three molecules of malonyl CoA." [GOC:tair_curators, ISBN:3110116251]
subset: gosubset_prok
synonym: "stilbene anabolism" EXACT []
synonym: "stilbene biosynthesis" EXACT []
synonym: "stilbene formation" EXACT []
synonym: "stilbene synthesis" EXACT []
is_a: GO:0009699 ! phenylpropanoid biosynthetic process
is_a: GO:0009810 ! stilbene metabolic process
is_a: GO:1900674 ! olefin biosynthetic process

[Term]
id: GO:0009812
name: flavonoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving flavonoids, a group of water-soluble phenolic derivatives containing a flavan skeleton including flavones, flavonols and flavanoids, and anthocyanins." [GOC:tair_curators, ISBN:0198547684]
subset: gosubset_prok
synonym: "flavonoid metabolism" EXACT []
is_a: GO:0071704 ! organic substance metabolic process

[Term]
id: GO:0009813
name: flavonoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of flavonoids, a group of phenolic derivatives containing a flavan skeleton." [GOC:tair_curators, ISBN:0198547684]
subset: gosubset_prok
synonym: "flavonoid anabolism" EXACT []
synonym: "flavonoid biosynthesis" EXACT []
synonym: "flavonoid formation" EXACT []
synonym: "flavonoid synthesis" EXACT []
xref: MetaCyc:PWY1F-FLAVSYN
xref: Wikipedia:Flavonoid
is_a: GO:0009812 ! flavonoid metabolic process
is_a: GO:1901576 ! organic substance biosynthetic process

[Term]
id: GO:0009814
name: defense response, incompatible interaction
namespace: biological_process
def: "A response of a plant to a pathogenic agent that prevents the occurrence or spread of disease." [GOC:lr]
synonym: "defence response incompatible interaction" EXACT []
synonym: "defence response to pathogen, incompatible interaction" EXACT []
synonym: "resistance response to pathogen" EXACT []
synonym: "response to pathogen (incompatible interaction)" EXACT []
is_a: GO:0045087 ! innate immune response
is_a: GO:0098542 ! defense response to other organism

[Term]
id: GO:0009815
name: 1-aminocyclopropane-1-carboxylate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-aminocyclopropane-1-carboxylate + L-ascorbate + O(2) = CO(2) + dehydroascorbate + ethylene + 2 H(2)O + hydrogen cyanide. Ethene is also known as ethylene." [EC:1.14.17.4, RHEA:23643]
synonym: "1-aminocyclopropane-1-carboxylate oxygenase (ethylene-forming)" EXACT [EC:1.14.17.4]
synonym: "ACC oxidase activity" EXACT []
synonym: "aminocyclopropanecarboxylate oxidase activity" EXACT [EC:1.14.17.4]
synonym: "ethene-forming enzyme" BROAD []
synonym: "ethylene-forming enzyme" BROAD []
xref: EC:1.14.17.4
xref: KEGG:R07214
xref: MetaCyc:ETHYL-RXN
xref: RHEA:23643
is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

[Term]
id: GO:0009816
name: defense response to bacterium, incompatible interaction
namespace: biological_process
def: "A response of an organism to a bacterium that prevents the occurrence or spread of disease." [GOC:lr]
synonym: "defence response to bacterium, incompatible interaction" EXACT []
synonym: "defence response to pathogenic bacteria, incompatible interaction" EXACT []
synonym: "defence response to pathogenic bacterium, incompatible interaction" EXACT []
synonym: "resistance response to pathogenic bacteria" EXACT []
synonym: "resistance response to pathogenic bacterium" EXACT []
synonym: "response to pathogenic bacteria (incompatible interaction)" EXACT []
synonym: "response to pathogenic bacterium (incompatible interaction)" EXACT []
is_a: GO:0009814 ! defense response, incompatible interaction
is_a: GO:0042742 ! defense response to bacterium

[Term]
id: GO:0009817
name: defense response to fungus, incompatible interaction
namespace: biological_process
def: "A response of an organism to a fungus that prevents the occurrence or spread of disease." [GOC:lr]
synonym: "defence response to fungus, incompatible interaction" EXACT []
synonym: "defence response to pathogenic fungi, incompatible interaction" EXACT []
synonym: "defence response to pathogenic fungus, incompatible interaction" EXACT []
synonym: "defense response to fungi, incompatible interaction" EXACT []
synonym: "resistance response to pathogenic fungi" EXACT []
synonym: "resistance response to pathogenic fungus" EXACT []
synonym: "response to pathogenic fungi (incompatible interaction)" EXACT []
synonym: "response to pathogenic fungus (incompatible interaction)" EXACT []
is_a: GO:0009814 ! defense response, incompatible interaction
is_a: GO:0050832 ! defense response to fungus

[Term]
id: GO:0009818
name: defense response to protozoan, incompatible interaction
namespace: biological_process
def: "A response of an organism to a protozoan that prevents the occurrence or spread of disease." [GOC:lr]
synonym: "defence response to pathogenic protozoa, incompatible interaction" EXACT []
synonym: "defence response to pathogenic protozoan, incompatible interaction" EXACT []
synonym: "defence response to protozoan, incompatible interaction" EXACT []
synonym: "resistance response to pathogenic protozoa" EXACT []
synonym: "resistance response to pathogenic protozoan" EXACT []
synonym: "response to pathogenic protozoa (incompatible interaction)" EXACT []
synonym: "response to pathogenic protozoan (incompatible interaction)" EXACT []
is_a: GO:0009814 ! defense response, incompatible interaction
is_a: GO:0042832 ! defense response to protozoan

[Term]
id: GO:0009819
name: drought recovery
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of prolonged deprivation of water that restores that organism to a normal (non-stressed) condition." [GOC:lr]
synonym: "drought tolerance" RELATED []
is_a: GO:0009414 ! response to water deprivation

[Term]
id: GO:0009820
name: alkaloid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving alkaloids, nitrogen containing natural products which are not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases)." [GOC:lr, ISBN:0122146743]
subset: goslim_chembl
subset: gosubset_prok
synonym: "alkaloid metabolism" EXACT []
is_a: GO:1901564 ! organonitrogen compound metabolic process

[Term]
id: GO:0009821
name: alkaloid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of alkaloids, nitrogen-containing natural products which are not otherwise classified as nonprotein amino acids, amines, peptides, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones, or primary metabolite (such as purine or pyrimidine bases)." [EC:1.1.1.51, GOC:lr, ISBN:0122146743]
subset: gosubset_prok
synonym: "alkaloid anabolism" EXACT []
synonym: "alkaloid biosynthesis" EXACT []
synonym: "alkaloid formation" EXACT []
synonym: "alkaloid synthesis" EXACT []
xref: UM-BBD_enzymeID:e0711
is_a: GO:0009820 ! alkaloid metabolic process
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process

[Term]
id: GO:0009822
name: alkaloid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of alkaloids, nitrogen containing natural products not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases)." [GOC:lr, ISBN:01221146743]
subset: gosubset_prok
synonym: "alkaloid breakdown" EXACT []
synonym: "alkaloid catabolism" EXACT []
synonym: "alkaloid degradation" EXACT []
is_a: GO:0009820 ! alkaloid metabolic process
is_a: GO:0044270 ! cellular nitrogen compound catabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process

[Term]
id: GO:0009823
name: cytokinin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cytokinins, a class of adenine-derived compounds that can function in plants as plant growth regulators." [GOC:lr]
subset: gosubset_prok
synonym: "cytokinin breakdown" EXACT []
synonym: "cytokinin catabolism" EXACT []
synonym: "cytokinin degradation" EXACT []
is_a: GO:0009690 ! cytokinin metabolic process
is_a: GO:0042447 ! hormone catabolic process

[Term]
id: GO:0009824
name: AMP dimethylallyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: AMP + dimethylallyl diphosphate = N(6)-(dimethylallyl)adenosine 5'-phosphate + diphosphate." [EC:2.5.1.27, RHEA:15288]
synonym: "2-isopentenyl-diphosphate:AMP 2-isopentenyltransferase activity" EXACT []
synonym: "2-isopentenyl-diphosphate:AMP delta2-isopentenyltransferase activity" EXACT [KEGG:R04038]
synonym: "adenylate dimethylallyltransferase activity" EXACT [EC:2.5.1.27]
synonym: "adenylate isopentenyltransferase activity" EXACT []
synonym: "cytokinin synthase activity" RELATED []
synonym: "dimethylallyl-diphosphate:AMP dimethylallyltransferase activity" EXACT [EC:2.5.1.27]
synonym: "isopentenyltransferase activity" BROAD []
xref: EC:2.5.1.27
xref: KEGG:R04038
xref: MetaCyc:RXN-4307
xref: RHEA:15288
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0009825
name: multidimensional cell growth
namespace: biological_process
def: "The process in which a cell irreversibly increases in size in two or three [spatial] dimensions or along two or three axes." [ISBN:0943088399]
subset: gosubset_prok
synonym: "cell growth in three dimensions" EXACT []
synonym: "cell growth in two dimensions" NARROW []
is_a: GO:0016049 ! cell growth

[Term]
id: GO:0009826
name: unidimensional cell growth
namespace: biological_process
def: "The process in which a cell irreversibly increases in size in one [spatial] dimension or along one axis, resulting in the morphogenesis of the cell." [ISBN:0943088399]
comment: Unidimensional cell growth refers to a change in both cell size and cell shape. For cell shape changes where cell size is not affected, consider instead the term 'regulation of cell shape ; GO:0008360' and its children.
subset: gosubset_prok
synonym: "cell elongation" NARROW []
synonym: "cell growth along one axis" EXACT []
synonym: "cell growth in one dimension" EXACT []
synonym: "cell morphogenesis by unidimensional growth" EXACT [GOC:dph, GOC:tb]
synonym: "polar cell growth" EXACT []
synonym: "polarized cell growth" EXACT []
is_a: GO:0000902 ! cell morphogenesis
is_a: GO:0016049 ! cell growth
is_a: GO:0060560 ! developmental growth involved in morphogenesis

[Term]
id: GO:0009827
name: plant-type cell wall modification
namespace: biological_process
def: "The series of events leading to chemical and structural alterations of an existing cellulose and pectin-containing cell wall that can result in loosening, increased extensibility or disassembly. An example of this is found in Arabidopsis thaliana." [GOC:lr, GOC:mtg_sensu]
synonym: "cellulose and pectin-containing cell wall modification" EXACT []
is_a: GO:0009664 ! plant-type cell wall organization
is_a: GO:0042545 ! cell wall modification

[Term]
id: GO:0009828
name: plant-type cell wall loosening
namespace: biological_process
def: "The series of events causing chemical and structural alterations of an existing cellulose and pectin-containing cell wall that results in greater extensibility of the wall. An example of this is found in Arabidopsis thaliana." [GOC:lr, GOC:mtg_sensu]
synonym: "cellulose and pectin-containing cell wall loosening" EXACT []
is_a: GO:0009827 ! plant-type cell wall modification

[Term]
id: GO:0009829
name: cell wall modification involved in fruit ripening
namespace: biological_process
def: "The series of events resulting in chemical or structural alterations of existing cell walls that contribute to fruit ripening." [GOC:lr]
synonym: "cell wall modification during ripening" RELATED [GOC:dph, GOC:tb]
is_a: GO:0009827 ! plant-type cell wall modification
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
intersection_of: GO:0042545 ! cell wall modification
intersection_of: part_of GO:0009835 ! fruit ripening
relationship: part_of GO:0009835 ! fruit ripening

[Term]
id: GO:0009830
name: cell wall modification involved in abscission
namespace: biological_process
def: "A cellular process that results in the breakdown of the cell wall that contributes to the process of abscission." [GOC:dph, GOC:lr, GOC:sdb_2009, GOC:tb]
synonym: "cell wall modification during abscission" RELATED [GOC:dph, GOC:tb]
is_a: GO:0009827 ! plant-type cell wall modification
is_a: GO:0044277 ! cell wall disassembly
intersection_of: GO:0042545 ! cell wall modification
intersection_of: part_of GO:0009838 ! abscission
relationship: part_of GO:0009838 ! abscission

[Term]
id: GO:0009831
name: plant-type cell wall modification involved in multidimensional cell growth
namespace: biological_process
def: "The series of events that occur during cell growth that result in chemical or structural changes to existing cell walls of the type composed chiefly of cellulose and pectin. An example of this is found in Arabidopsis thaliana." [GOC:lr, GOC:mtg_sensu]
synonym: "cell wall modification during cell expansion" BROAD []
synonym: "cellulose and pectin-containing cell wall modification during multidimensional cell growth" RELATED []
is_a: GO:0009827 ! plant-type cell wall modification
is_a: GO:0042547 ! cell wall modification involved in multidimensional cell growth
intersection_of: GO:0009827 ! plant-type cell wall modification
intersection_of: part_of GO:0009825 ! multidimensional cell growth
relationship: part_of GO:0009825 ! multidimensional cell growth

[Term]
id: GO:0009832
name: plant-type cell wall biogenesis
namespace: biological_process
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellulose and pectin-containing cell wall. An example of this is found in Arabidopsis thaliana." [GOC:go_curators, GOC:lr, GOC:mtg_sensu]
synonym: "cell wall anabolism" BROAD []
synonym: "cell wall assembly" BROAD []
synonym: "cell wall biosynthetic process" BROAD []
synonym: "cell wall formation" BROAD []
synonym: "cell wall synthesis" BROAD []
synonym: "cellulose and pectin-containing cell wall biogenesis" EXACT []
is_a: GO:0042546 ! cell wall biogenesis
is_a: GO:0071669 ! plant-type cell wall organization or biogenesis

[Term]
id: GO:0009833
name: plant-type primary cell wall biogenesis
namespace: biological_process
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of cellulose and pectin-containing cell walls that form adjacent to the middle lamella following cell division and during cell expansion. An example of this is found in Arabidopsis thaliana." [GOC:lr, GOC:mtg_sensu]
synonym: "cellulose and pectin-containing primary cell wall biogenesis" EXACT []
synonym: "primary cell wall anabolism" BROAD []
synonym: "primary cell wall biogenesis" EXACT []
synonym: "primary cell wall biosynthetic process" BROAD []
synonym: "primary cell wall formation" BROAD []
synonym: "primary cell wall synthesis" BROAD []
is_a: GO:0009832 ! plant-type cell wall biogenesis
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:0000281 ! mitotic cytokinesis

[Term]
id: GO:0009834
name: plant-type secondary cell wall biogenesis
namespace: biological_process
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of inextensible cellulose- and pectin-containing cell walls that are formed between the plasma membrane and primary cell wall after cell expansion is complete. An example of this is found in Arabidopsis thaliana." [GOC:lr, GOC:mtg_sensu]
synonym: "cellulose and pectin-containing secondary cell wall biogenesis" EXACT []
synonym: "secondary cell wall anabolism" BROAD []
synonym: "secondary cell wall biogenesis" EXACT []
synonym: "secondary cell wall biosynthetic process" BROAD []
synonym: "secondary cell wall formation" BROAD []
synonym: "secondary cell wall synthesis" BROAD []
is_a: GO:0009832 ! plant-type cell wall biogenesis

[Term]
id: GO:0009835
name: fruit ripening
namespace: biological_process
def: "An aging process that has as participant a fruit. Ripening causes changes in one or more characteristics of a fruit (color, aroma, flavor, texture, hardness, cell wall structure) and may make it more attractive to animals and aid in seed dispersal." [GOC:lr]
subset: goslim_plant
synonym: "fruit maturation" RELATED [GOC:PO_curators]
synonym: "fruit senescence" RELATED [GOC:PO_curators]
xref: Wikipedia:Ripening
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0007568 ! aging
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0071695 ! anatomical structure maturation
relationship: part_of GO:0007275 ! multicellular organism development
relationship: part_of GO:0010154 ! fruit development

[Term]
id: GO:0009836
name: fruit ripening, climacteric
namespace: biological_process
def: "A fruit ripening process that involves a burst of respiration and ethylene (ethene) evolution at the onset." [GOC:lr, ISBN:0521587840]
is_a: GO:0009835 ! fruit ripening

[Term]
id: GO:0009837
name: fruit ripening, non-climacteric
namespace: biological_process
def: "A fruit ripening process that does not involve a respiratory burst." [GOC:lr, ISBN:0521587840]
is_a: GO:0009835 ! fruit ripening

[Term]
id: GO:0009838
name: abscission
namespace: biological_process
def: "The controlled shedding of a body part." [ISBN:0140514031]
subset: goslim_plant
xref: Wikipedia:Abscission
is_a: GO:0032502 ! developmental process
relationship: part_of GO:0007275 ! multicellular organism development

[Term]
id: GO:0009839
name: obsolete SCF complex substrate recognition subunit
namespace: cellular_component
def: "OBSOLETE. The portion of the SCF ubiquitin ligase complex that contains sites required for recognition (and recruitment) of the substrate to the complex." [PMID:11790542, PMID:9857172]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "SCF complex substrate recognition subunit" EXACT []
is_obsolete: true
replaced_by: GO:0019005

[Term]
id: GO:0009840
name: chloroplastic endopeptidase Clp complex
namespace: cellular_component
def: "A Clp endopeptidase complex located in the chloroplast." [GOC:mah]
is_a: GO:0009368 ! endopeptidase Clp complex
is_a: GO:0044434 ! chloroplast part
intersection_of: GO:0009368 ! endopeptidase Clp complex
intersection_of: part_of GO:0009570 ! chloroplast stroma
relationship: part_of GO:0009570 ! chloroplast stroma

[Term]
id: GO:0009841
name: mitochondrial endopeptidase Clp complex
namespace: cellular_component
def: "A Clp endopeptidase complex located in the mitochondrion." [GOC:mah]
is_a: GO:0009368 ! endopeptidase Clp complex
is_a: GO:0098798 ! mitochondrial protein complex
intersection_of: GO:0009368 ! endopeptidase Clp complex
intersection_of: part_of GO:0005739 ! mitochondrion
relationship: part_of GO:0005739 ! mitochondrion
relationship: part_of GO:0005759 ! mitochondrial matrix

[Term]
id: GO:0009842
name: cyanelle
namespace: cellular_component
def: "A plastid that contains unstacked, phycobilisome-bearing thylakoid membranes and is surrounded by a double membrane with a peptidoglycan layer in the intermembrane space between the two envelope membranes. Cyanelles are characteristic of algae in the class Glaucophyta, and may represent an ancestral form of plastid." [ISBN:052131687, ISBN:1402001894]
subset: gosubset_prok
synonym: "cyanoplast" EXACT [ISBN:1402001894]
synonym: "muroplast" EXACT [ISBN:1402001894]
is_a: GO:0009536 ! plastid

[Term]
id: GO:0009843
name: cyanelle thylakoid
namespace: cellular_component
def: "A thylakoid found in a cyanelle, which is a type of plastid found in certain algae. The cyanelle contains a photosynthetic membrane resembling that of cyanobacteria." [GOC:lr, GOC:mah, GOC:mtg_sensu]
subset: gosubset_prok
is_a: GO:0031976 ! plastid thylakoid
intersection_of: GO:0009579 ! thylakoid
intersection_of: part_of GO:0009842 ! cyanelle
relationship: part_of GO:0009842 ! cyanelle

[Term]
id: GO:0009844
name: obsolete germination
namespace: biological_process
alt_id: GO:0009565
def: "OBSOLETE. The physiological and developmental changes by a seed, spore, pollen grain (microspore), or zygote that occur after release from dormancy, and encompassing events prior to and including the first visible indications of growth." [GOC:lr]
comment: This term was made obsolete because it is a grouping term without biological significance.
synonym: "germination" EXACT []
is_obsolete: true

[Term]
id: GO:0009845
name: seed germination
namespace: biological_process
def: "The physiological and developmental changes that occur in a seed commencing with water uptake (imbibition) and terminating with the elongation of the embryonic axis." [PMID:8281041]
xref: Wikipedia:Germination#Seed_germination
is_a: GO:0044707 ! single-multicellular organism process
relationship: part_of GO:0090351 ! seedling development

[Term]
id: GO:0009846
name: pollen germination
namespace: biological_process
def: "The physiological and developmental changes that occur in a heterosporous plant pollen grain, beginning with hydration and terminating with the emergence of the pollen tube through the aperture." [GOC:lr, http://www.bio.uu.nl, ISBN:0943088399]
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0044707 ! single-multicellular organism process
relationship: part_of GO:0009856 ! pollination

[Term]
id: GO:0009847
name: spore germination
namespace: biological_process
def: "The physiological and developmental changes that occur in a spore following release from dormancy up to the earliest signs of growth (e.g. emergence from a spore wall)." [GOC:lr]
subset: gosubset_prok
is_a: GO:0032502 ! developmental process

[Term]
id: GO:0009848
name: indoleacetic acid biosynthetic process via tryptophan
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of indole-3-acetic acid that occurs through metabolism of L-tryptophan." [GOC:lm, GOC:lr, PMID:10375566]
subset: gosubset_prok
synonym: "IAA biosynthetic process via tryptophan" EXACT []
synonym: "indoleacetic acid anabolism via tryptophan" EXACT []
synonym: "indoleacetic acid formation via tryptophan" EXACT []
synonym: "indoleacetic acid synthesis via tryptophan" EXACT []
xref: MetaCyc:PWY-581
is_a: GO:0006568 ! tryptophan metabolic process
is_a: GO:0009684 ! indoleacetic acid biosynthetic process

[Term]
id: GO:0009849
name: tryptophan-independent indoleacetic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of indoleacetic acid, independent of tryptophan." [GOC:go_curators, GOC:lm, GOC:lr, PMID:10375566]
subset: gosubset_prok
synonym: "indoleacetic acid biosynthesis, tryptophan-independent" EXACT []
synonym: "indoleacetic acid biosynthetic process, tryptophan-independent" EXACT []
synonym: "tryptophan-independent IAA biosynthetic process" EXACT []
synonym: "tryptophan-independent indoleacetic acid anabolism" EXACT []
synonym: "tryptophan-independent indoleacetic acid biosynthesis" EXACT []
synonym: "tryptophan-independent indoleacetic acid formation" EXACT []
synonym: "tryptophan-independent indoleacetic acid synthesis" EXACT []
xref: MetaCyc:PWY-581
is_a: GO:0009684 ! indoleacetic acid biosynthetic process

[Term]
id: GO:0009850
name: auxin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving auxins, a group of plant hormones that regulate aspects of plant growth." [GOC:lr]
subset: gosubset_prok
synonym: "auxin metabolism" EXACT []
is_a: GO:0042445 ! hormone metabolic process
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0009851
name: auxin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of auxins, plant hormones that regulate aspects of plant growth." [GOC:lm, GOC:lr, ISBN:0122146743]
subset: gosubset_prok
synonym: "auxin anabolism" EXACT []
synonym: "auxin biosynthesis" EXACT []
synonym: "auxin formation" EXACT []
synonym: "auxin synthesis" EXACT []
is_a: GO:0009850 ! auxin metabolic process
is_a: GO:0042446 ! hormone biosynthetic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0009852
name: auxin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of auxins, a group of plant hormones that regulate aspects of plant growth." [GOC:lm, GOC:lr, ISBN:0198547684]
subset: gosubset_prok
synonym: "auxin breakdown" EXACT []
synonym: "auxin catabolism" EXACT []
synonym: "auxin degradation" EXACT []
is_a: GO:0009850 ! auxin metabolic process
is_a: GO:0042447 ! hormone catabolic process

[Term]
id: GO:0009853
name: photorespiration
namespace: biological_process
def: "A light-dependent catabolic process occurring concomitantly with photosynthesis in plants (especially C3 plants) whereby dioxygen (O2) is consumed and carbon dioxide (CO2) is evolved. The substrate is glycolate formed in large quantities in chloroplasts from 2-phosphoglycolate generated from ribulose 1,5-bisphosphate by the action of ribulose-bisphosphate carboxylase; the glycolate enters the peroxisomes where it is converted by glycolate oxidase to glyoxylate which undergoes transamination to glycine. This then passes into the mitochondria where it is decarboxylated forming one molecule of serine for every two molecules of glycine. This pathway also exists in photosynthetic bacteria." [ISBN:0198506732]
subset: gosubset_prok
xref: MetaCyc:PWY-181
xref: Wikipedia:Photorespiration
is_a: GO:0043094 ! cellular metabolic compound salvage

[Term]
id: GO:0009854
name: oxidative photosynthetic carbon pathway
namespace: biological_process
def: "The reactions of the C2 pathway bring about the metabolic conversion of two molecules of 2-phosphoglycolate to one molecule of 3-phosphoglycerate, which can be used by the C3 cycle, and one molecule of carbon dioxide (CO2)." [ISBN:00943088399]
subset: gosubset_prok
is_a: GO:0043094 ! cellular metabolic compound salvage
relationship: part_of GO:0009853 ! photorespiration

[Term]
id: GO:0009855
name: determination of bilateral symmetry
namespace: biological_process
def: "The establishment of an organism's body plan or part of an organism with respect to a single longitudinal plane. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry." [GOC:go_curators]
synonym: "determination of bilateral asymmetry" EXACT [GOC:dph]
is_a: GO:0009799 ! specification of symmetry

[Term]
id: GO:0009856
name: pollination
namespace: biological_process
def: "The cascade of biological processes occurring in plants beginning when the pollen lands on the stigma and continuing up to, but not including, fertilization, as defined by sperm-central cell fusion." [GOC:tb, PMID:10973091]
subset: goslim_plant
xref: Wikipedia:Pollination
is_a: GO:0044703 ! multi-organism reproductive process
is_a: GO:0044706 ! multi-multicellular organism process

[Term]
id: GO:0009858
name: obsolete compatible pollen-pistil interaction
namespace: biological_process
def: "OBSOLETE. An interaction between a pollen grain and pistil that results in unimpeded growth of the pollen tube through the stigma and style." [GOC:lr, ISBN:0387987819]
comment: This term was made obsolete because it represents a phenotype.
synonym: "compatible pollen-pistil interaction" EXACT []
is_obsolete: true

[Term]
id: GO:0009859
name: pollen hydration
namespace: biological_process
def: "The process in which water is taken up by pollen." [GOC:lr]
is_a: GO:0006833 ! water transport
is_a: GO:0044702 ! single organism reproductive process
relationship: part_of GO:0009875 ! pollen-pistil interaction

[Term]
id: GO:0009860
name: pollen tube growth
namespace: biological_process
def: "Growth of pollen via tip extension of the intine wall." [ISBN:00943088399]
is_a: GO:0000904 ! cell morphogenesis involved in differentiation
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0009932 ! cell tip growth
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0048588 ! developmental cell growth
relationship: part_of GO:0048868 ! pollen tube development

[Term]
id: GO:0009861
name: jasmonic acid and ethylene-dependent systemic resistance
namespace: biological_process
def: "The jasmonic acid and ethylene (ethene) dependent process that confers broad spectrum systemic resistance to disease in response to wounding or a pathogen." [GOC:jy, PMID:10234273]
synonym: "jasmonic acid and ethene-dependent systemic resistance" EXACT []
synonym: "jasmonic acid/ethylene-dependent systemic resistance" EXACT []
is_a: GO:0009611 ! response to wounding
is_a: GO:0009814 ! defense response, incompatible interaction

[Term]
id: GO:0009862
name: systemic acquired resistance, salicylic acid mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals mediated by salicylic acid involved in systemic acquired resistance." [GOC:jy]
synonym: "salicylic acid mediated signaling pathway (systemic acquired resistance)" EXACT []
synonym: "systemic acquired resistance, salicylic acid mediated signalling pathway" EXACT []
is_a: GO:0009863 ! salicylic acid mediated signaling pathway
intersection_of: GO:0009863 ! salicylic acid mediated signaling pathway
intersection_of: part_of GO:0009627 ! systemic acquired resistance
relationship: part_of GO:0009627 ! systemic acquired resistance

[Term]
id: GO:0009863
name: salicylic acid mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals mediated by salicylic acid." [GOC:jy]
synonym: "salicylic acid mediated signal transduction" EXACT [GOC:signaling]
synonym: "salicylic acid mediated signalling pathway" EXACT []
synonym: "salicylic acid-mediated signaling pathway" EXACT []
is_a: GO:0007165 ! signal transduction
relationship: part_of GO:0071446 ! cellular response to salicylic acid stimulus

[Term]
id: GO:0009864
name: induced systemic resistance, jasmonic acid mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals mediated by jasmonic acid involved in induced systemic resistance." [GOC:jy]
synonym: "induced systemic resistance, jasmonic acid mediated signalling pathway" EXACT []
synonym: "jasmonic acid mediated signaling pathway (induced systemic resistance)" EXACT []
is_a: GO:0002218 ! activation of innate immune response
is_a: GO:0002252 ! immune effector process
is_a: GO:0009867 ! jasmonic acid mediated signaling pathway
intersection_of: GO:0009867 ! jasmonic acid mediated signaling pathway
intersection_of: part_of GO:0009682 ! induced systemic resistance
relationship: part_of GO:0009682 ! induced systemic resistance

[Term]
id: GO:0009865
name: pollen tube adhesion
namespace: biological_process
def: "The process in which the pollen tube adheres to cells of the stigma and style." [GOC:tair_curators, PMID:12602877]
is_a: GO:0044703 ! multi-organism reproductive process
is_a: GO:0098609 ! cell-cell adhesion
is_a: GO:0098740 ! multi organism cell adhesion
relationship: part_of GO:0009875 ! pollen-pistil interaction
relationship: part_of GO:0048868 ! pollen tube development

[Term]
id: GO:0009866
name: induced systemic resistance, ethylene mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals mediated by ethylene (ethene) involved in induced systemic resistance." [GOC:jy]
synonym: "ethene mediated signaling pathway (induced systemic resistance)" EXACT []
synonym: "ethylene mediated signaling pathway (induced systemic resistance)" EXACT []
synonym: "induced systemic resistance, ethene mediated signaling pathway" EXACT []
synonym: "induced systemic resistance, ethene mediated signalling pathway" EXACT []
synonym: "induced systemic resistance, ethylene mediated signalling pathway" EXACT []
is_a: GO:0002218 ! activation of innate immune response
is_a: GO:0002252 ! immune effector process
is_a: GO:0009873 ! ethylene-activated signaling pathway
intersection_of: GO:0009873 ! ethylene-activated signaling pathway
intersection_of: part_of GO:0009682 ! induced systemic resistance
relationship: part_of GO:0009682 ! induced systemic resistance

[Term]
id: GO:0009867
name: jasmonic acid mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals mediated by jasmonic acid." [GOC:jy, PMID:16478936, PMID:19522558, PMID:20159850]
synonym: "JA signaling" EXACT [PMID:20159850]
synonym: "jasmonate signaling" RELATED [PMID:16478936]
synonym: "jasmonic acid mediated signalling pathway" EXACT []
is_a: GO:0009755 ! hormone-mediated signaling pathway
relationship: part_of GO:0071395 ! cellular response to jasmonic acid stimulus

[Term]
id: GO:0009868
name: jasmonic acid and ethylene-dependent systemic resistance, jasmonic acid mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals mediated by jasmonic acid involved in jasmonic acid/ethylene (ethene) dependent systemic resistance." [GOC:jy]
synonym: "jasmonic acid and ethene-dependent systemic resistance, jasmonic acid mediated signaling pathway" EXACT []
synonym: "jasmonic acid mediated signaling pathway (jasmonic acid/ethene-dependent systemic resistance)" EXACT []
synonym: "jasmonic acid mediated signaling pathway (jasmonic acid/ethylene-dependent systemic resistance)" EXACT []
synonym: "jasmonic acid/ethene-dependent systemic resistance, jasmonic acid mediated signaling pathway" EXACT []
synonym: "jasmonic acid/ethene-dependent systemic resistance, jasmonic acid mediated signalling pathway" EXACT []
synonym: "jasmonic acid/ethylene-dependent systemic resistance, jasmonic acid mediated signaling pathway" EXACT []
synonym: "jasmonic acid/ethylene-dependent systemic resistance, jasmonic acid mediated signalling pathway" EXACT []
is_a: GO:0009867 ! jasmonic acid mediated signaling pathway
intersection_of: GO:0009867 ! jasmonic acid mediated signaling pathway
intersection_of: part_of GO:0009861 ! jasmonic acid and ethylene-dependent systemic resistance
relationship: part_of GO:0009861 ! jasmonic acid and ethylene-dependent systemic resistance
relationship: part_of GO:0032260 ! response to jasmonic acid stimulus involved in jasmonic acid and ethylene-dependent systemic resistance

[Term]
id: GO:0009869
name: obsolete incompatible pollen-pistil interaction
namespace: biological_process
def: "OBSOLETE. An interaction between a pollen grain and pistil that results in inhibition of pollen germination/growth." [PMID:10375566]
comment: This term was made obsolete because it represents a phenotype.
synonym: "incompatible pollen-pistil interaction" EXACT []
is_obsolete: true

[Term]
id: GO:0009870
name: defense response signaling pathway, resistance gene-dependent
namespace: biological_process
def: "A series of molecular signals that depends upon R-genes and is activated during defense response." [GOC:jy, GOC:mah, PMID:11418339]
synonym: "defence response signaling pathway, resistance gene-dependent" EXACT []
synonym: "defence response signalling pathway, resistance gene-dependent" EXACT []
synonym: "defense response signalling pathway, resistance gene-dependent" EXACT []
is_a: GO:0002218 ! activation of innate immune response
is_a: GO:0007165 ! signal transduction

[Term]
id: GO:0009871
name: jasmonic acid and ethylene-dependent systemic resistance, ethylene mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals mediated by ethylene (ethene) involved in jasmonic acid/ethylene dependent systemic resistance." [GOC:jy]
synonym: "ethene mediated signaling pathway (jasmonic acid/ethene-dependent systemic resistance)" EXACT []
synonym: "ethylene mediated signaling pathway (jasmonic acid/ethylene-dependent systemic resistance)" EXACT []
synonym: "jasmonic acid and ethene-dependent systemic resistance, ethene mediated signaling pathway" EXACT []
synonym: "jasmonic acid/ethene-dependent systemic resistance, ethene mediated signaling pathway" EXACT []
synonym: "jasmonic acid/ethene-dependent systemic resistance, ethene mediated signalling pathway" EXACT []
synonym: "jasmonic acid/ethylene-dependent systemic resistance, ethylene mediated signaling pathway" EXACT []
synonym: "jasmonic acid/ethylene-dependent systemic resistance, ethylene mediated signalling pathway" EXACT []
is_a: GO:0009873 ! ethylene-activated signaling pathway
intersection_of: GO:0009873 ! ethylene-activated signaling pathway
intersection_of: part_of GO:0009861 ! jasmonic acid and ethylene-dependent systemic resistance
relationship: part_of GO:0009861 ! jasmonic acid and ethylene-dependent systemic resistance

[Term]
id: GO:0009872
name: obsolete gametophytic self-incompatibility
namespace: biological_process
def: "OBSOLETE. A mechanism that functions to prevent self-fertilization in flowering plants that is determined by the diploid genotype of the parent plant. In sporophytic incompatibility the pollen does not germinate, consequently fertilization does not take place." [ISBN:0387987819]
comment: This term was made obsolete because it represents a phenotype.
synonym: "gametophytic self-incompatibility" EXACT []
is_obsolete: true

[Term]
id: GO:0009873
name: ethylene-activated signaling pathway
namespace: biological_process
def: "A series of molecular signals generated by the reception of ethylene (ethene, C2H4) by a receptor and ending with modulation of a cellular process, e.g. transcription." [GOC:jy, PMID:24012247]
synonym: "ethene mediated signaling pathway" RELATED []
synonym: "ethene mediated signalling pathway" EXACT []
synonym: "ethylene mediated signaling pathway" RELATED []
synonym: "ethylene mediated signalling pathway" RELATED []
synonym: "ethylene signal transduction" RELATED [PMID:24012247]
synonym: "ethylene signaling pathway" RELATED [PMID:24287137]
is_a: GO:0000160 ! phosphorelay signal transduction system
is_a: GO:0009755 ! hormone-mediated signaling pathway
relationship: part_of GO:0071369 ! cellular response to ethylene stimulus

[Term]
id: GO:0009874
name: obsolete sporophytic self-incompatibility
namespace: biological_process
def: "OBSOLETE. A mechanism that functions to prevent self-fertilization in flowering plants that is determined by the diploid genotype of the parent plant. In sporophytic incompatibility the pollen does not germinate, consequently fertilization does not take place." [ISBN:0387987819]
comment: This term was made obsolete because it represents a phenotype.
synonym: "sporophytic self-incompatibility" EXACT []
is_obsolete: true

[Term]
id: GO:0009875
name: pollen-pistil interaction
namespace: biological_process
def: "The interaction between a pollen grain and pistil." [GOC:go_curators]
subset: goslim_plant
is_a: GO:0007154 ! cell communication
is_a: GO:0044702 ! single organism reproductive process
relationship: part_of GO:0009856 ! pollination

[Term]
id: GO:0009876
name: pollen adhesion
namespace: biological_process
def: "The process in which pollen deposited on the stigma adheres to cells of the stigma." [GOC:tair_curators]
is_a: GO:0016337 ! single organismal cell-cell adhesion
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0044763 ! single-organism cellular process
relationship: part_of GO:0009875 ! pollen-pistil interaction

[Term]
id: GO:0009877
name: nodulation
namespace: biological_process
def: "The formation of nitrogen-fixing root nodules on plant roots." [UniProtKB-KW:KW-0536]
synonym: "nodule development" EXACT [GOC:jl]
synonym: "nodule formation" EXACT [GOC:jl]
is_a: GO:0044403 ! symbiosis, encompassing mutualism through parasitism

[Term]
id: GO:0009878
name: nodule morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the nodule are generated and organized." [GOC:jid]
is_a: GO:0009886 ! post-embryonic morphogenesis
is_a: GO:0044111 ! development involved in symbiotic interaction
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: part_of GO:0009877 ! nodulation
relationship: part_of GO:0009877 ! nodulation

[Term]
id: GO:0009879
name: determination of radial symmetry
namespace: biological_process
def: "The establishment of an organism's body plan or a part of an organism such that it is symmetric around a central axis." [GOC:go_curators]
synonym: "determination of radial asymmetry" EXACT [GOC:dph]
is_a: GO:0009799 ! specification of symmetry
relationship: part_of GO:0009956 ! radial pattern formation

[Term]
id: GO:0009880
name: embryonic pattern specification
namespace: biological_process
def: "The process that results in the patterns of cell differentiation that will arise in an embryo." [GOC:go_curators, ISBN:0521436125]
synonym: "embryonic pattern biosynthesis" BROAD []
synonym: "embryonic pattern formation" BROAD []
synonym: "ventral/lateral system" RELATED []
is_a: GO:0007389 ! pattern specification process
relationship: part_of GO:0009790 ! embryo development

[Term]
id: GO:0009881
name: photoreceptor activity
namespace: molecular_function
def: "The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation." [GOC:ai, GOC:go_curators]
subset: gosubset_prok
synonym: "blue-sensitive opsin" NARROW []
synonym: "green-sensitive opsin" NARROW []
synonym: "long-wave-sensitive opsin" NARROW []
synonym: "opsin" NARROW []
synonym: "red-sensitive opsin" NARROW []
synonym: "short-wave-sensitive opsin" NARROW []
synonym: "UV-sensitive opsin" NARROW []
synonym: "violet-sensitive opsin" NARROW []
is_a: GO:0038023 ! signaling receptor activity

[Term]
id: GO:0009882
name: blue light photoreceptor activity
namespace: molecular_function
def: "The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 400-470nm. The response may involve a change in conformation." [GOC:tb]
subset: gosubset_prok
is_a: GO:0009881 ! photoreceptor activity
relationship: part_of GO:0009785 ! blue light signaling pathway

[Term]
id: GO:0009883
name: red or far-red light photoreceptor activity
namespace: molecular_function
def: "The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 660-730nm. The response may involve a change in conformation." [GOC:lr]
synonym: "red/far-red light photoreceptor activity" EXACT []
is_a: GO:0009881 ! photoreceptor activity
relationship: part_of GO:0009585 ! red, far-red light phototransduction

[Term]
id: GO:0009884
name: cytokinin receptor activity
namespace: molecular_function
def: "Combining with a cytokinin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:lr, GOC:signaling]
is_a: GO:0004888 ! transmembrane signaling receptor activity
relationship: part_of GO:0009736 ! cytokinin-activated signaling pathway

[Term]
id: GO:0009885
name: transmembrane histidine kinase cytokinin receptor activity
namespace: molecular_function
def: "Combining with a cytokinin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-histidine = ADP + a protein-L-histidine phosphate." [GOC:lr, GOC:mah]
is_a: GO:0009784 ! transmembrane receptor histidine kinase activity
is_a: GO:0009884 ! cytokinin receptor activity

[Term]
id: GO:0009886
name: post-embryonic morphogenesis
namespace: biological_process
def: "The process, occurring after embryonic development, by which anatomical structures are generated and organized." [GOC:go_curators]
synonym: "post-embryonic morphogenesis of an anatomical structure" EXACT []
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0009791 ! post-embryonic development

[Term]
id: GO:0009887
name: organ morphogenesis
namespace: biological_process
def: "Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544]
synonym: "histogenesis and organogenesis" BROAD []
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0048513 ! animal organ development

[Term]
id: GO:0009888
name: tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]
synonym: "histogenesis" EXACT []
synonym: "histogenesis and organogenesis" BROAD []
xref: Wikipedia:Histogenesis
is_a: GO:0048856 ! anatomical structure development

[Term]
id: GO:0009889
name: regulation of biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of anabolism" EXACT []
synonym: "regulation of biosynthesis" EXACT []
synonym: "regulation of formation" EXACT []
synonym: "regulation of synthesis" EXACT []
is_a: GO:0019222 ! regulation of metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009058 ! biosynthetic process
relationship: regulates GO:0009058 ! biosynthetic process

[Term]
id: GO:0009890
name: negative regulation of biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of biosynthetic process" EXACT []
synonym: "down-regulation of biosynthetic process" EXACT []
synonym: "downregulation of biosynthetic process" EXACT []
synonym: "inhibition of biosynthetic process" NARROW []
synonym: "negative regulation of anabolism" EXACT []
synonym: "negative regulation of biosynthesis" EXACT []
synonym: "negative regulation of formation" EXACT []
synonym: "negative regulation of synthesis" EXACT []
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0009892 ! negative regulation of metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009058 ! biosynthetic process
relationship: negatively_regulates GO:0009058 ! biosynthetic process

[Term]
id: GO:0009891
name: positive regulation of biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of biosynthetic process" NARROW []
synonym: "positive regulation of anabolism" EXACT []
synonym: "positive regulation of biosynthesis" EXACT []
synonym: "positive regulation of formation" EXACT []
synonym: "positive regulation of synthesis" EXACT []
synonym: "stimulation of biosynthetic process" NARROW []
synonym: "up regulation of biosynthetic process" EXACT []
synonym: "up-regulation of biosynthetic process" EXACT []
synonym: "upregulation of biosynthetic process" EXACT []
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0009893 ! positive regulation of metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009058 ! biosynthetic process
relationship: positively_regulates GO:0009058 ! biosynthetic process

[Term]
id: GO:0009892
name: negative regulation of metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of metabolic process" EXACT []
synonym: "down-regulation of metabolic process" EXACT []
synonym: "downregulation of metabolic process" EXACT []
synonym: "inhibition of metabolic process" NARROW []
synonym: "negative regulation of metabolism" EXACT []
is_a: GO:0019222 ! regulation of metabolic process
is_a: GO:0048519 ! negative regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008152 ! metabolic process
relationship: negatively_regulates GO:0008152 ! metabolic process

[Term]
id: GO:0009893
name: positive regulation of metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of metabolic process" NARROW []
synonym: "positive regulation of metabolism" EXACT []
synonym: "stimulation of metabolic process" NARROW []
synonym: "up regulation of metabolic process" EXACT []
synonym: "up-regulation of metabolic process" EXACT []
synonym: "upregulation of metabolic process" EXACT []
is_a: GO:0019222 ! regulation of metabolic process
is_a: GO:0048518 ! positive regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008152 ! metabolic process
relationship: positively_regulates GO:0008152 ! metabolic process

[Term]
id: GO:0009894
name: regulation of catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of breakdown" EXACT []
synonym: "regulation of catabolism" EXACT []
synonym: "regulation of degradation" EXACT []
is_a: GO:0019222 ! regulation of metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009056 ! catabolic process
relationship: regulates GO:0009056 ! catabolic process

[Term]
id: GO:0009895
name: negative regulation of catabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of catabolic process" EXACT []
synonym: "down-regulation of catabolic process" EXACT []
synonym: "downregulation of catabolic process" EXACT []
synonym: "inhibition of catabolic process" NARROW []
synonym: "negative regulation of breakdown" EXACT []
synonym: "negative regulation of catabolism" EXACT []
synonym: "negative regulation of degradation" EXACT []
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0009894 ! regulation of catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009056 ! catabolic process
relationship: negatively_regulates GO:0009056 ! catabolic process

[Term]
id: GO:0009896
name: positive regulation of catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of catabolic process" NARROW []
synonym: "positive regulation of breakdown" EXACT []
synonym: "positive regulation of catabolism" EXACT []
synonym: "positive regulation of degradation" EXACT []
synonym: "stimulation of catabolic process" NARROW []
synonym: "up regulation of catabolic process" EXACT []
synonym: "up-regulation of catabolic process" EXACT []
synonym: "upregulation of catabolic process" EXACT []
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0009894 ! regulation of catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009056 ! catabolic process
relationship: positively_regulates GO:0009056 ! catabolic process

[Term]
id: GO:0009897
name: external side of plasma membrane
namespace: cellular_component
def: "The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb]
subset: gosubset_prok
synonym: "external leaflet of plasma membrane" EXACT [GOC:ab]
synonym: "juxtamembrane" BROAD []
synonym: "outer surface of cytoplasmic membrane" EXACT []
is_a: GO:0044459 ! plasma membrane part
is_a: GO:0098552 ! side of membrane
relationship: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0009986 ! cell surface

[Term]
id: GO:0009898
name: cytoplasmic side of plasma membrane
namespace: cellular_component
def: "The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb]
subset: gosubset_prok
synonym: "internal leaflet of plasma membrane" EXACT [GOC:ab]
synonym: "internal side of plasma membrane" EXACT []
synonym: "juxtamembrane" BROAD []
is_a: GO:0044459 ! plasma membrane part
is_a: GO:0098562 ! cytoplasmic side of membrane
relationship: part_of GO:0005886 ! plasma membrane

[Term]
id: GO:0009899
name: ent-kaurene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ent-copalyl diphosphate = ent-kaur-16-ene + diphosphate." [EC:4.2.3.19, RHEA:22223]
synonym: "ent-copalyl-diphosphate diphosphate-lyase (cyclizing)" EXACT [EC:4.2.3.19]
synonym: "ent-copalyl-diphosphate diphosphate-lyase (cyclizing, ent-kaurene-forming)" EXACT [EC:4.2.3.19]
synonym: "ent-kaurene synthase B activity" NARROW [EC:4.2.3.19]
synonym: "ent-kaurene synthetase B activity" NARROW [EC:4.2.3.19]
xref: EC:4.2.3.19
xref: KEGG:R05092
xref: MetaCyc:4.2.3.19-RXN
xref: RHEA:22223
is_a: GO:0010333 ! terpene synthase activity

[Term]
id: GO:0009900
name: dehiscence
namespace: biological_process
def: "The opening of an anther, fruit or other structure, which permits the escape of reproductive bodies contained within it." [ISBN:0879015322]
xref: Wikipedia:Dehiscence_(botany)
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0048609 ! multicellular organismal reproductive process

[Term]
id: GO:0009901
name: anther dehiscence
namespace: biological_process
def: "The dehiscence of an anther to release the pollen grains contained within it." [GOC:tb]
is_a: GO:0009900 ! dehiscence
relationship: part_of GO:0048653 ! anther development

[Term]
id: GO:0009902
name: chloroplast relocation
namespace: biological_process
def: "The process in which chloroplasts in photosynthetic cells migrate toward illuminated sites to optimize photosynthesis and move away from excessively illuminated areas to protect the photosynthetic machinery." [PMID:11309623]
synonym: "chloroplast movement" EXACT [GOC:tb, PMID:18715957]
is_a: GO:0009658 ! chloroplast organization
is_a: GO:0019750 ! chloroplast localization
is_a: GO:0051667 ! establishment of plastid localization

[Term]
id: GO:0009903
name: chloroplast avoidance movement
namespace: biological_process
def: "The relocation process in which chloroplasts in photosynthetic cells avoid strong light and move away from it in order to preserve the photosynthetic machinery." [GOC:tb, PMID:11978863]
synonym: "high-fluence-rate response" RELATED []
is_a: GO:0009902 ! chloroplast relocation

[Term]
id: GO:0009904
name: chloroplast accumulation movement
namespace: biological_process
def: "The relocation process in which chloroplasts in photosynthetic cells move toward a brighter area in a cell to optimize photosynthesis." [GOC:tb, PMID:11978863]
synonym: "low-fluence-rate response" RELATED []
is_a: GO:0009902 ! chloroplast relocation

[Term]
id: GO:0009905
name: ent-copalyl diphosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = ent-copalyl diphosphate." [EC:5.5.1.13, RHEA:14844]
synonym: "diterpene cyclase activity" BROAD []
synonym: "ent-copalyl-diphosphate lyase (decyclizing)" EXACT [EC:5.5.1.13]
synonym: "ent-kaurene synthase A activity" NARROW [EC:5.5.1.13]
synonym: "ent-kaurene synthetase A activity" NARROW [EC:5.5.1.13]
xref: EC:5.5.1.13
xref: KEGG:R02068
xref: MetaCyc:5.5.1.13-RXN
xref: RHEA:14844
is_a: GO:0016872 ! intramolecular lyase activity

[Term]
id: GO:0009906
name: response to photoperiod, blue light
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of a blue light photoperiod stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm." [GOC:go_curators, GOC:mtg_far_red]
is_a: GO:0009637 ! response to blue light
is_a: GO:0009648 ! photoperiodism

[Term]
id: GO:0009907
name: response to photoperiod, red light
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red light photoperiod stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm." [GOC:go_curators, GOC:mtg_far_red]
is_a: GO:0009648 ! photoperiodism
is_a: GO:0010114 ! response to red light

[Term]
id: GO:0009908
name: flower development
namespace: biological_process
alt_id: GO:0048409
def: "The process whose specific outcome is the progression of the flower over time, from its formation to the mature structure. The flower is the reproductive structure in a plant, and its development begins with the transition of the vegetative or inflorescence meristem into a floral meristem." [GOC:tb, ISBN:0879015322]
subset: goslim_plant
is_a: GO:0090567 ! reproductive shoot system development

[Term]
id: GO:0009909
name: regulation of flower development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of flower development." [GOC:go_curators]
is_a: GO:0048580 ! regulation of post-embryonic development
is_a: GO:0048831 ! regulation of shoot system development
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009908 ! flower development
relationship: regulates GO:0009908 ! flower development

[Term]
id: GO:0009910
name: negative regulation of flower development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of flower development." [GOC:go_curators]
synonym: "down regulation of flower development" EXACT []
synonym: "down-regulation of flower development" EXACT []
synonym: "downregulation of flower development" EXACT []
synonym: "inhibition of flower development" NARROW []
is_a: GO:0009909 ! regulation of flower development
is_a: GO:0048581 ! negative regulation of post-embryonic development
is_a: GO:2000242 ! negative regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009908 ! flower development
relationship: negatively_regulates GO:0009908 ! flower development

[Term]
id: GO:0009911
name: positive regulation of flower development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of flower development." [GOC:go_curators]
synonym: "activation of flower development" NARROW []
synonym: "stimulation of flower development" NARROW []
synonym: "up regulation of flower development" EXACT []
synonym: "up-regulation of flower development" EXACT []
synonym: "upregulation of flower development" EXACT []
is_a: GO:0009909 ! regulation of flower development
is_a: GO:0048582 ! positive regulation of post-embryonic development
is_a: GO:2000243 ! positive regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009908 ! flower development
relationship: positively_regulates GO:0009908 ! flower development

[Term]
id: GO:0009912
name: auditory receptor cell fate commitment
namespace: biological_process
def: "The process in which the cellular identity of auditory hair cells is acquired and determined." [GOC:lr]
synonym: "auditory hair cell fate commitment" EXACT []
is_a: GO:0060120 ! inner ear receptor cell fate commitment
is_a: GO:0072148 ! epithelial cell fate commitment
relationship: part_of GO:0042491 ! auditory receptor cell differentiation

[Term]
id: GO:0009913
name: epidermal cell differentiation
namespace: biological_process
alt_id: GO:0043355
def: "The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis." [GOC:dph, GOC:go_curators, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb]
synonym: "hypodermal cell differentiation" RELATED [GOC:kmv, GOC:rk]
is_a: GO:0030855 ! epithelial cell differentiation
relationship: part_of GO:0008544 ! epidermis development

[Term]
id: GO:0009914
name: hormone transport
namespace: biological_process
def: "The directed movement of hormones into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:tb]
subset: goslim_pir
is_a: GO:0010817 ! regulation of hormone levels
is_a: GO:0044765 ! single-organism transport

[Term]
id: GO:0009915
name: phloem sucrose loading
namespace: biological_process
def: "The process of loading sucrose into the sieve tube or companion cell of the phloem for long distance transport from source to sink." [GOC:sm]
synonym: "phloem loading" BROAD []
is_a: GO:0010233 ! phloem transport
is_a: GO:0015770 ! sucrose transport

[Term]
id: GO:0009916
name: alternative oxidase activity
namespace: molecular_function
def: "Catalysis of the oxidation of ubiquinol by diverting electrons from the standard electron transfer chain, transferring them from ubiquinol to oxygen and generating water as the product." [ISBN:0943088399]
is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor

[Term]
id: GO:0009917
name: sterol 5-alpha reductase activity
namespace: molecular_function
def: "Catalysis of the removal of a C-5 double bond in the B ring of a sterol." [ISBN:0943088399]
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0009918
name: sterol delta7 reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-dehydroepisterol = 24-methylenecholesterol." [ISBN:0943088399]
synonym: "sterol delta-7 reductase activity" EXACT []
xref: MetaCyc:RXN-707
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0009919
name: obsolete cytokinesis (sensu Viridiplantae)
namespace: biological_process
def: "OBSOLETE. The division of a cell into two daughter cells with cell walls." [GOC:tb]
comment: This term was made obsolete because its meaning was changed significantly.
synonym: "cytokinesis (sensu Viridiplantae)" EXACT []
is_obsolete: true
consider: GO:0000911

[Term]
id: GO:0009920
name: cell plate formation involved in plant-type cell wall biogenesis
namespace: biological_process
def: "The cell cycle process in which the cell plate is formed at the equator of the spindle in the dividing cells during early telophase. An example of this is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tb, ISBN:0879015322]
synonym: "cell plate formation involved in cellulose and pectin-containing cell wall biogenesis" EXACT []
is_a: GO:0000919 ! cell plate assembly
intersection_of: GO:0000919 ! cell plate assembly
intersection_of: part_of GO:0009832 ! plant-type cell wall biogenesis
relationship: part_of GO:0007067 ! mitotic nuclear division
relationship: part_of GO:0009832 ! plant-type cell wall biogenesis
relationship: part_of GO:0061640 ! cytoskeleton-dependent cytokinesis

[Term]
id: GO:0009921
name: auxin efflux carrier complex
namespace: cellular_component
def: "The protein complex associated with the plasma membrane of certain plant cells (e.g. root cortex, epidermal cells) that functions to transport auxin out of the cell." [PMID:9843496]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0009922
name: fatty acid elongase activity
namespace: molecular_function
def: "Catalysis of the reaction: fatty acid (C-16 or longer) + 2-C = fatty acid (C-16 or longer + 2-C)." [GOC:tb]
xref: MetaCyc:ICOSANOYL-COA-SYNTHASE-RXN
xref: Reactome:REACT_22097 "palmitoyl-CoA + malonyl-CoA => 3-oxooctadecanoyl-CoA (3-oxostearoyl-CoA) + CO2 + CoASH [ELOVL2], Homo sapiens"
xref: Reactome:REACT_22133 "palmitoyl-CoA + malonyl-CoA => 3-oxooctadecanoyl-CoA (3-oxostearoyl-CoA) + CO2 + CoASH [ELOVL3], Homo sapiens"
xref: Reactome:REACT_22192 "arachidoyl-CoA + malonyl-CoA => 3-oxobehenoyl-CoA + CO2 + CoASH [ELOVL7], Homo sapiens"
xref: Reactome:REACT_22219 "palmitoyl-CoA + malonyl-CoA => 3-oxooctadecanoyl-CoA (3-oxostearoyl-CoA) + CO2 + CoASH [ELOVL6], Homo sapiens"
xref: Reactome:REACT_22242 "lignoceroyl-CoA + malonyl-CoA => 3-oxocerotoyl-CoA + CO2 + CoASH [ELOVL4], Homo sapiens"
xref: Reactome:REACT_22267 "lignoceroyl-CoA + malonyl-CoA => 3-oxocerotoyl-CoA + CO2 + CoASH [Elovl4], Mus musculus"
xref: Reactome:REACT_22270 "palmitoyl-CoA + malonyl-CoA => 3-oxooctadecanoyl-CoA (3-oxostearoyl-CoA) + CO2 + CoASH [ELOVL1], Homo sapiens"
xref: Reactome:REACT_22350 "arachidonoyl-CoA + malonyl-CoA => 3-oxo-(7,10,13,16)-docosatetraenoyl-CoA + CO2 + CoASH [ELOVL5], Homo sapiens"
is_a: GO:0004312 ! fatty acid synthase activity

[Term]
id: GO:0009923
name: fatty acid elongase complex
namespace: cellular_component
def: "A tetrameric complex of four different subunits which catalyzes the elongation of fatty acids chains 2 carbon units at a time in the synthesis of very long chain fatty acids." [GOC:tb]
is_a: GO:0044432 ! endoplasmic reticulum part
is_a: GO:0098796 ! membrane protein complex
is_a: GO:1990234 ! transferase complex
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane

[Term]
id: GO:0009924
name: octadecanal decarbonylase activity
namespace: molecular_function
def: "Catalysis of the reaction: octadecanal = heptadecane + CO." [EC:4.1.99.5, GOC:tb]
synonym: "octadecanal alkane-lyase activity" EXACT []
xref: EC:4.1.99.5
xref: MetaCyc:OCTADECANAL-DECARBONYLASE-RXN
xref: RHEA:30418
is_a: GO:0071771 ! aldehyde decarbonylase activity

[Term]
id: GO:0009925
name: basal plasma membrane
namespace: cellular_component
def: "The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]
is_a: GO:0098590 ! plasma membrane region
relationship: part_of GO:0016323 ! basolateral plasma membrane
relationship: part_of GO:0045178 ! basal part of cell

[Term]
id: GO:0009926
name: auxin polar transport
namespace: biological_process
def: "The unidirectional movement of auxin in the stem from tip to base along the vector of gravity or basipetally." [GOC:sm]
is_a: GO:0060918 ! auxin transport

[Term]
id: GO:0009927
name: histidine phosphotransfer kinase activity
namespace: molecular_function
def: "Serves as a phospho-His intermediate enabling the transfer of phospho group between a hybrid kinase and a response regulator." [PMID:11842140]
subset: gosubset_prok
is_a: GO:0004871 ! signal transducer activity
is_a: GO:0016301 ! kinase activity

[Term]
id: GO:0009930
name: longitudinal side of cell surface
namespace: cellular_component
def: "The side of the cell parallel to the zygotic axis." [GOC:mtg_sensu, GOC:sm]
is_a: GO:0044464 ! cell part
relationship: part_of GO:0009986 ! cell surface

[Term]
id: GO:0009931
name: calcium-dependent protein serine/threonine kinase activity
namespace: molecular_function
def: "Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions are dependent on the presence of calcium ions." [GOC:mah]
is_a: GO:0004674 ! protein serine/threonine kinase activity
is_a: GO:0010857 ! calcium-dependent protein kinase activity

[Term]
id: GO:0009932
name: cell tip growth
namespace: biological_process
def: "Growth that occurs specifically at the tip of a cell." [GOC:jid]
is_a: GO:0009826 ! unidimensional cell growth

[Term]
id: GO:0009933
name: meristem structural organization
namespace: biological_process
def: "Organization of a region of tissue in a plant that is composed of one or more undifferentiated cells capable of undergoing mitosis and differentiation, thereby effecting growth and development of a plant by giving rise to more meristem or specialized tissue." [GOC:sm, ISBN:0198547684]
synonym: "meristem organisation" BROAD []
synonym: "meristem organization" BROAD []
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0048507 ! meristem development

[Term]
id: GO:0009934
name: regulation of meristem structural organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of meristem organization." [GOC:jid]
synonym: "regulation of meristem organisation" EXACT []
synonym: "regulation of meristem organization" BROAD [GOC:dph, GOC:tb]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0048509 ! regulation of meristem development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009933 ! meristem structural organization
relationship: regulates GO:0009933 ! meristem structural organization

[Term]
id: GO:0009935
name: obsolete nutrient import
namespace: biological_process
def: "OBSOLETE. The directed movement of nutrients into a cell or organelle." [GOC:sm]
comment: This term was made obsolete because "nutrient" is not defined, and does not have a consistent meaning.
subset: gosubset_prok
synonym: "nutrient import" EXACT []
synonym: "nutrient uptake" EXACT []
is_obsolete: true
consider: GO:0006810

[Term]
id: GO:0009936
name: obsolete expansin
namespace: molecular_function
def: "OBSOLETE. A group of proteins located within the cell walls of plants, both dicots and grasses, that play an essential role in loosening cell walls during cell growth. They are hydrophobic, non glycosylated proteins of about 30kDa." [ISBN:0198547684]
comment: This term was made obsolete because it represents a gene product.
synonym: "expansin" EXACT []
is_obsolete: true
consider: GO:0009505
consider: GO:0016049

[Term]
id: GO:0009937
name: regulation of gibberellic acid mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gibberellic acid mediated signaling." [GOC:go_curators]
synonym: "regulation of gibberellic acid mediated signalling" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009740 ! gibberellic acid mediated signaling pathway
relationship: regulates GO:0009740 ! gibberellic acid mediated signaling pathway

[Term]
id: GO:0009938
name: negative regulation of gibberellic acid mediated signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of gibberellic acid mediated signaling activity." [GOC:sm]
synonym: "down regulation of gibberellic acid mediated signaling" EXACT []
synonym: "down-regulation of gibberellic acid mediated signaling" EXACT []
synonym: "downregulation of gibberellic acid mediated signaling" EXACT []
synonym: "inhibition of gibberellic acid mediated signaling" NARROW []
synonym: "negative regulation of gibberellic acid mediated signalling" EXACT []
is_a: GO:0009937 ! regulation of gibberellic acid mediated signaling pathway
is_a: GO:0009968 ! negative regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009740 ! gibberellic acid mediated signaling pathway
relationship: negatively_regulates GO:0009740 ! gibberellic acid mediated signaling pathway

[Term]
id: GO:0009939
name: positive regulation of gibberellic acid mediated signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of gibberellic acid mediated signaling activity." [GOC:sm]
synonym: "activation of gibberellic acid mediated signaling" NARROW []
synonym: "positive regulation of gibberellic acid mediated signalling" EXACT []
synonym: "stimulation of gibberellic acid mediated signaling" NARROW []
synonym: "up regulation of gibberellic acid mediated signaling" EXACT []
synonym: "up-regulation of gibberellic acid mediated signaling" EXACT []
synonym: "upregulation of gibberellic acid mediated signaling" EXACT []
is_a: GO:0009937 ! regulation of gibberellic acid mediated signaling pathway
is_a: GO:0009967 ! positive regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009740 ! gibberellic acid mediated signaling pathway
relationship: positively_regulates GO:0009740 ! gibberellic acid mediated signaling pathway

[Term]
id: GO:0009940
name: amino-terminal vacuolar sorting propeptide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an amino terminal propeptide, which functions as a sorting signal to sort away the soluble vacuolar protein from Golgi to lytic vacuole via clathrin-coated vesicles." [GOC:sm, PMID:10871276]
is_a: GO:0010209 ! vacuolar sorting signal binding

[Term]
id: GO:0009941
name: chloroplast envelope
namespace: cellular_component
def: "The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:tb]
is_a: GO:0009526 ! plastid envelope
is_a: GO:0044434 ! chloroplast part

[Term]
id: GO:0009942
name: longitudinal axis specification
namespace: biological_process
def: "The establishment, maintenance and elaboration of the longitudinal axis. In plants, this is the axis that runs from the shoot to the root." [GOC:tb]
synonym: "apical-basal pattern specification" EXACT []
synonym: "longitudinal axis determination" RELATED [GOC:dph]
is_a: GO:0000578 ! embryonic axis specification
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
relationship: part_of GO:0009793 ! embryo development ending in seed dormancy

[Term]
id: GO:0009943
name: adaxial/abaxial axis specification
namespace: biological_process
def: "The establishment, maintenance and elaboration of the adaxial / abaxial axis. Adaxial refers to being situated toward an axis of an anatomical structure. Abaxial refers to being situated away from an axis of an anatomical structure." [GOC:dph, GOC:tb]
synonym: "adaxial/abaxial determination" RELATED [GOC:dph]
is_a: GO:0009798 ! axis specification
relationship: part_of GO:0009955 ! adaxial/abaxial pattern specification

[Term]
id: GO:0009944
name: polarity specification of adaxial/abaxial axis
namespace: biological_process
def: "The process resulting in the establishment of polarity along the adaxial/abaxial axis. Adaxial refers to being situated toward an axis of an anatomical structure. Abaxial refers to being situated away from an axis of an anatomical structure." [GOC:dph, GOC:tb]
is_a: GO:0065001 ! specification of axis polarity
relationship: part_of GO:0009943 ! adaxial/abaxial axis specification

[Term]
id: GO:0009945
name: radial axis specification
namespace: biological_process
def: "The establishment, maintenance and elaboration of an axis that initiates at a point and radiates outward from the point." [GOC:dph, GOC:go_curators, GOC:isa_complete]
is_a: GO:0009798 ! axis specification
relationship: part_of GO:0009956 ! radial pattern formation

[Term]
id: GO:0009946
name: proximal/distal axis specification
namespace: biological_process
def: "The establishment, maintenance and elaboration of the proximal/distal axis. The proximal/distal axis is defined by a line that runs from main body (proximal end) of an organism outward (distal end)." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "proximal/distal axis determination" RELATED [GOC:dph]
synonym: "proximodistal axis specification" EXACT []
is_a: GO:0009798 ! axis specification
relationship: part_of GO:0009954 ! proximal/distal pattern formation

[Term]
id: GO:0009947
name: centrolateral axis specification
namespace: biological_process
def: "The establishment, maintenance and elaboration of the centrolateral axis. In plants, this axis is duplicated and runs from the midrib to the margin of the leaf." [GOC:dsz, GOC:tb, ISBN:0865427429]
synonym: "centrolateral axis determination" RELATED [GOC:dph]
synonym: "mediolateral axis specification" EXACT []
is_a: GO:0009798 ! axis specification
relationship: part_of GO:0097353 ! centrolateral pattern formation

[Term]
id: GO:0009948
name: anterior/posterior axis specification
namespace: biological_process
def: "The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "anterior/posterior axis determination" RELATED [GOC:dph]
is_a: GO:0009798 ! axis specification
relationship: part_of GO:0009952 ! anterior/posterior pattern specification

[Term]
id: GO:0009949
name: polarity specification of anterior/posterior axis
namespace: biological_process
def: "Any process resulting in the establishment of polarity along the anterior/posterior axis." [GOC:go_curators]
is_a: GO:0065001 ! specification of axis polarity
relationship: part_of GO:0009948 ! anterior/posterior axis specification

[Term]
id: GO:0009950
name: dorsal/ventral axis specification
namespace: biological_process
def: "The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "dorsal-ventral axis specification" EXACT [GOC:mah]
synonym: "dorsal/ventral axis determination" RELATED [GOC:dph]
synonym: "dorsoventral axis specification" EXACT [GOC:mah]
is_a: GO:0009798 ! axis specification
relationship: part_of GO:0009953 ! dorsal/ventral pattern formation

[Term]
id: GO:0009951
name: polarity specification of dorsal/ventral axis
namespace: biological_process
def: "Any process resulting in the establishment of polarity along the dorsal/ventral axis." [GOC:go_curators]
synonym: "polarity specification of dorsal-ventral axis" EXACT [GOC:mah]
synonym: "polarity specification of dorsoventral axis" EXACT [GOC:mah]
is_a: GO:0065001 ! specification of axis polarity
relationship: part_of GO:0009950 ! dorsal/ventral axis specification

[Term]
id: GO:0009952
name: anterior/posterior pattern specification
namespace: biological_process
def: "The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]
synonym: "anterior/posterior pattern formation" RELATED []
is_a: GO:0003002 ! regionalization

[Term]
id: GO:0009953
name: dorsal/ventral pattern formation
namespace: biological_process
def: "The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]
synonym: "dorsal-ventral pattern formation" EXACT [GOC:mah]
synonym: "dorsal/ventral pattern specification" NARROW []
synonym: "dorsoventral pattern formation" EXACT [GOC:mah]
is_a: GO:0003002 ! regionalization

[Term]
id: GO:0009954
name: proximal/distal pattern formation
namespace: biological_process
def: "The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis. The proximal/distal axis is defined by a line that runs from main body (proximal end) of an organism outward (distal end)." [GOC:dph, GOC:go_curators, GOC:isa_complete]
synonym: "proximal/distal pattern specification" NARROW []
is_a: GO:0003002 ! regionalization

[Term]
id: GO:0009955
name: adaxial/abaxial pattern specification
namespace: biological_process
def: "The regionalization process in which differences in cell differentiation along the adaxial/abaxial are generated. Adaxial refers to being situated toward an axis of an anatomical structure. Abaxial refers to being situated away from an axis of an anatomical structure." [GOC:dph, GOC:isa_complete, GOC:tb]
synonym: "adaxial/abaxial pattern formation" RELATED []
is_a: GO:0003002 ! regionalization

[Term]
id: GO:0009956
name: radial pattern formation
namespace: biological_process
def: "The regionalization process that results in defined areas around a point in which specific types of cell differentiation will occur." [GOC:dph, GOC:go_curators, GOC:isa_complete]
synonym: "radial pattern specification" NARROW []
is_a: GO:0003002 ! regionalization

[Term]
id: GO:0009957
name: epidermal cell fate specification
namespace: biological_process
alt_id: GO:0043356
def: "The process in which a cell becomes capable of differentiating autonomously into an epidermal cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:mtg_sensu, GOC:sm]
synonym: "hypodermal cell fate specification" RELATED [GOC:kmv, GOC:rk]
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0009913 ! epidermal cell differentiation

[Term]
id: GO:0009958
name: positive gravitropism
namespace: biological_process
def: "The orientation of plant parts towards gravity." [GOC:sm]
synonym: "root gravitropism" NARROW []
is_a: GO:0009630 ! gravitropism

[Term]
id: GO:0009959
name: negative gravitropism
namespace: biological_process
def: "The orientation of plant parts away from gravity." [GOC:sm]
synonym: "shoot gravitropism" NARROW []
is_a: GO:0009630 ! gravitropism

[Term]
id: GO:0009960
name: endosperm development
namespace: biological_process
def: "The process whose specific outcome is the progression of the endosperm over time, from its formation to the mature structure. The endosperm is formed during fertilization and provides nutrients to the developing embryo." [GOC:sm]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0009888 ! tissue development
relationship: part_of GO:0048316 ! seed development

[Term]
id: GO:0009961
name: response to 1-aminocyclopropane-1-carboxylic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-aminocyclopropane-1-carboxylic acid stimulus." [GOC:jl]
is_a: GO:0043200 ! response to amino acid

[Term]
id: GO:0009962
name: regulation of flavonoid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of flavonoids." [GOC:tb]
subset: gosubset_prok
synonym: "regulation of flavonoid anabolism" EXACT []
synonym: "regulation of flavonoid biosynthesis" EXACT []
synonym: "regulation of flavonoid formation" EXACT []
synonym: "regulation of flavonoid synthesis" EXACT []
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0080090 ! regulation of primary metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009813 ! flavonoid biosynthetic process
relationship: regulates GO:0009813 ! flavonoid biosynthetic process

[Term]
id: GO:0009963
name: positive regulation of flavonoid biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of flavonoids." [GOC:tb]
subset: gosubset_prok
synonym: "activation of flavonoid biosynthetic process" NARROW []
synonym: "positive regulation of flavonoid anabolism" EXACT []
synonym: "positive regulation of flavonoid biosynthesis" EXACT []
synonym: "positive regulation of flavonoid formation" EXACT []
synonym: "positive regulation of flavonoid synthesis" EXACT []
synonym: "stimulation of flavonoid biosynthetic process" NARROW []
synonym: "up regulation of flavonoid biosynthetic process" EXACT []
synonym: "up-regulation of flavonoid biosynthetic process" EXACT []
synonym: "upregulation of flavonoid biosynthetic process" EXACT []
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:0009962 ! regulation of flavonoid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009813 ! flavonoid biosynthetic process
relationship: positively_regulates GO:0009813 ! flavonoid biosynthetic process

[Term]
id: GO:0009964
name: negative regulation of flavonoid biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of flavonoids." [GOC:tb]
subset: gosubset_prok
synonym: "down regulation of flavonoid biosynthetic process" EXACT []
synonym: "down-regulation of flavonoid biosynthetic process" EXACT []
synonym: "downregulation of flavonoid biosynthetic process" EXACT []
synonym: "inhibition of flavonoid biosynthetic process" NARROW []
synonym: "negative regulation of flavonoid anabolism" EXACT []
synonym: "negative regulation of flavonoid biosynthesis" EXACT []
synonym: "negative regulation of flavonoid formation" EXACT []
synonym: "negative regulation of flavonoid synthesis" EXACT []
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0009962 ! regulation of flavonoid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009813 ! flavonoid biosynthetic process
relationship: negatively_regulates GO:0009813 ! flavonoid biosynthetic process

[Term]
id: GO:0009965
name: leaf morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the leaf are generated and organized." [GOC:go_curators]
is_a: GO:0009887 ! organ morphogenesis
relationship: part_of GO:0010016 ! shoot system morphogenesis
relationship: part_of GO:0048366 ! leaf development

[Term]
id: GO:0009966
name: regulation of signal transduction
namespace: biological_process
alt_id: GO:0035466
def: "Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm]
subset: gosubset_prok
synonym: "regulation of signaling pathway" RELATED []
synonym: "regulation of signalling pathway" RELATED [GOC:mah]
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0023051 ! regulation of signaling
is_a: GO:0048583 ! regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007165 ! signal transduction
relationship: regulates GO:0007165 ! signal transduction

[Term]
id: GO:0009967
name: positive regulation of signal transduction
namespace: biological_process
alt_id: GO:0035468
def: "Any process that activates or increases the frequency, rate or extent of signal transduction." [GOC:sm]
subset: gosubset_prok
synonym: "activation of signal transduction" NARROW []
synonym: "positive regulation of signaling pathway" RELATED []
synonym: "positive regulation of signalling pathway" RELATED [GOC:mah]
synonym: "stimulation of signal transduction" NARROW []
synonym: "up regulation of signal transduction" EXACT []
synonym: "up-regulation of signal transduction" EXACT []
synonym: "upregulation of signal transduction" EXACT []
xref: Reactome:REACT_6227 "Activated DTOR also phosphorylates D4EBP, Drosophila melanogaster"
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0010647 ! positive regulation of cell communication
is_a: GO:0023056 ! positive regulation of signaling
is_a: GO:0048584 ! positive regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007165 ! signal transduction
relationship: positively_regulates GO:0007165 ! signal transduction

[Term]
id: GO:0009968
name: negative regulation of signal transduction
namespace: biological_process
alt_id: GO:0035467
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction." [GOC:sm]
subset: gosubset_prok
synonym: "down regulation of signal transduction" EXACT []
synonym: "down-regulation of signal transduction" EXACT []
synonym: "downregulation of signal transduction" EXACT []
synonym: "inhibition of signal transduction" NARROW []
synonym: "negative regulation of signaling pathway" RELATED []
synonym: "negative regulation of signalling pathway" RELATED [GOC:mah]
xref: Reactome:REACT_6334 "DTSC1 AND DTSC2 form a complex, Drosophila melanogaster"
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0010648 ! negative regulation of cell communication
is_a: GO:0023057 ! negative regulation of signaling
is_a: GO:0048585 ! negative regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007165 ! signal transduction
relationship: negatively_regulates GO:0007165 ! signal transduction

[Term]
id: GO:0009969
name: xyloglucan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of xyloglucan, the cross-linking glycan composed of (1->4)-beta-D glucan backbone substituted at regular intervals with beta-D-xylosyl-(1->6) residues, which is present in the primary cell wall of most higher plants." [GOC:sm]
subset: gosubset_prok
synonym: "xyloglucan anabolism" EXACT []
synonym: "xyloglucan biosynthesis" EXACT []
synonym: "xyloglucan formation" EXACT []
synonym: "xyloglucan synthesis" EXACT []
is_a: GO:0009250 ! glucan biosynthetic process
is_a: GO:0010411 ! xyloglucan metabolic process

[Term]
id: GO:0009970
name: cellular response to sulfate starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of sulfate." [GOC:sm]
synonym: "cellular response to sulphate starvation" EXACT []
is_a: GO:0009267 ! cellular response to starvation

[Term]
id: GO:0009971
name: anastral spindle assembly involved in male meiosis
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the anastral spindle in male meiotic cells." [GOC:tb, PMID:11973272]
is_a: GO:0007053 ! spindle assembly involved in male meiosis
is_a: GO:0055048 ! anastral spindle assembly
intersection_of: GO:0055048 ! anastral spindle assembly
intersection_of: part_of GO:0007140 ! male meiosis
relationship: part_of GO:0007140 ! male meiosis

[Term]
id: GO:0009972
name: cytidine deamination
namespace: biological_process
def: "The removal of amino group in the presence of water." [GOC:sm]
subset: gosubset_prok
is_a: GO:0006216 ! cytidine catabolic process

[Term]
id: GO:0009973
name: adenylyl-sulfate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: AMP + sulfite + acceptor = adenylyl sulfate + reduced acceptor." [EC:1.8.99.2, PMID:5421934]
subset: gosubset_prok
synonym: "adenosine 5'-phosphosulfate reductase" EXACT [EC:1.8.99.2]
synonym: "adenosine phosphosulfate reductase activity" EXACT [EC:1.8.99.2]
synonym: "adenylyl-sulphate reductase activity" EXACT [EC:1.8.99.2]
synonym: "AMP, sulfite:(acceptor) oxidoreductase (adenosine-5'-phosphosulfate-forming)" EXACT [EC:1.8.99.2]
synonym: "AMP, sulfite:acceptor oxidoreductase (adenosine-5'-phosphosulfate-forming)" EXACT [EC:1.8.99.2]
synonym: "APS reductase activity" EXACT [EC:1.8.99.2]
synonym: "APS-reductase" EXACT [EC:1.8.99.2]
xref: EC:1.8.99.2
xref: MetaCyc:ADENYLYLSULFATE-REDUCTASE-RXN
xref: RHEA:24243
is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors

[Term]
id: GO:0009974
name: zeinoxanthin epsilon hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: zeinoxanthin + NADPH + O2 + H+ = lutein + NADP+ + H2O. Adds a hydroxyl group to the epsilon ring of the alpha-carotene." [MetaCyc:RXN-5962, PMID:8837513]
xref: EC:1.14.99.-
xref: MetaCyc:RXN-5962
is_a: GO:0072374 ! carotene epsilon hydroxylase activity

[Term]
id: GO:0009975
name: cyclase activity
namespace: molecular_function
def: "Catalysis of a ring closure reaction." [ISBN:0198547684]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0009976
name: tocopherol cyclase activity
namespace: molecular_function
def: "Catalysis of the reaction: alkene group + alcohol group on same molecule = cyclic ether. Substrates are 2-methyl-6-phytyl-1,4- hydroquinone (forms delta-tocopherol) and 2,3-dimethyl-5-phytyl-1,4-hydroquinone (forms gamma-tocopherol)." [PMID:12213958]
is_a: GO:0009975 ! cyclase activity

[Term]
id: GO:0009977
name: proton motive force dependent protein transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of proteins from one side of the membrane to the other. Transportation is dependent on pH gradient across the membrane." [PMID:11526245]
synonym: "delta-pH-dependent protein transporter activity" EXACT []
synonym: "pH-dependent protein transporter activity" EXACT []
is_a: GO:0015291 ! secondary active transmembrane transporter activity
is_a: GO:0015450 ! P-P-bond-hydrolysis-driven protein transmembrane transporter activity

[Term]
id: GO:0009978
name: allene oxide synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 13(S)-hydroperoxylinolenate = 12,13(S)-epoxylinolenate + H2O." [EC:4.2.1.92, MetaCyc:RXN1F-19, PMID:9778849]
synonym: "(9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate 12,13-hydro-lyase [(9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate-forming]" RELATED [EC:4.2.1.92]
synonym: "HPI" RELATED [EC:4.2.1.92]
synonym: "linoleate hydroperoxide isomerase" RELATED [EC:4.2.1.92]
synonym: "linoleic acid hydroperoxide isomerase" RELATED [EC:4.2.1.92]
xref: MetaCyc:RXN1F-19
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0009979
name: 16:0 monogalactosyldiacylglycerol desaturase activity
namespace: molecular_function
def: "Catalysis of the introduction of an omega-3 double bond into an unsaturated 16-carbon fatty acid in a monogalactosyldiacylglycerol molecule." [GOC:mah, MetaCyc:RXN-1728, MetaCyc:RXN-8304, MetaCyc:RXN-8307]
is_a: GO:0042389 ! omega-3 fatty acid desaturase activity

[Term]
id: GO:0009980
name: obsolete glutamate carboxypeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of C-terminal glutamate residues from a wide range of N-acylating groups, including peptidyl, aminoacyl, benzoyl, benzyloxycarbonyl, folyl and pteroyl groups." [EC:3.4.17.11, MetaCyc:3.4.17.11-RXN]
comment: This term was made obsolete because it represents a gene product, and the substrate specificity it refers to is not cleanly defined.
subset: gosubset_prok
synonym: "carboxypeptidase G activity" BROAD [EC:3.4.17.11]
synonym: "carboxypeptidase G1 activity" RELATED [EC:3.4.17.11]
synonym: "carboxypeptidase G2 activity" RELATED [EC:3.4.17.11]
synonym: "glutamate carboxypeptidase activity" EXACT []
synonym: "glutamyl carboxypeptidase activity" EXACT [EC:3.4.17.11]
synonym: "N-pteroyl-L-glutamate hydrolase activity" EXACT [EC:3.4.17.11]
xref: EC:3.4.17.11
xref: MetaCyc:3.4.17.11-RXN
is_obsolete: true
replaced_by: GO:0004180

[Term]
id: GO:0009982
name: pseudouridine synthase activity
namespace: molecular_function
alt_id: GO:0016439
def: "Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [EC:5.4.99.12, GOC:mah]
comment: Note that this term should not be confused with 'pseudouridylate synthase activity ; GO:0004730', which refers to the formation of free pseudouridine from uracil and ribose-5-phosphate.
subset: gosubset_prok
synonym: "transfer ribonucleate pseudouridine synthetase activity" NARROW [EC:5.4.99.12]
synonym: "transfer RNA pseudouridine synthetase activity" NARROW [EC:5.4.99.12]
synonym: "tRNA pseudouridylate synthase I activity" NARROW [EC:5.4.99.12]
synonym: "tRNA-pseudouridine synthase activity" NARROW []
synonym: "tRNA-pseudouridine synthase I activity" NARROW []
synonym: "tRNA-uridine isomerase activity" NARROW [EC:5.4.99.12]
synonym: "tRNA-uridine uracilmutase activity" NARROW [EC:5.4.99.12]
xref: EC:5.4.99.12
xref: MetaCyc:TRNA-PSEUDOURIDINE-SYNTHASE-I-RXN
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0009983
name: obsolete tyrosine aminopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of N-terminal tyrosine from a peptide." [GOC:sm, ISBN:0198506732]
comment: This term was made obsolete because it represents a gene product, and the substrate specificity it refers to is not cleanly defined.
synonym: "tyrosine aminopeptidase activity" EXACT []
is_obsolete: true
replaced_by: GO:0004177

[Term]
id: GO:0009984
name: obsolete adenylate forming enzyme activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: substrate + ATP = substrate-AMP + diphosphate." [PMID:12084835]
comment: This term was made obsolete because it does not refer to a specific reaction but rather to a process which results in the formation of AMP.
synonym: "adenylate forming enzyme activity" EXACT []
is_obsolete: true
consider: GO:0046033

[Term]
id: GO:0009985
name: obsolete dihydroflavonol(thiole) lyase activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:tb]
comment: This term was made obsolete because there is no record of why it was added, and no evidence can be found to suggest that this activity exists.
synonym: "dihydroflavonol(thiole) lyase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0009986
name: cell surface
namespace: cellular_component
alt_id: GO:0009928
alt_id: GO:0009929
def: "The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]
comment: Note that this term is intended to annotate gene products that are attached (integrated or loosely bound) to the plasma membrane or cell wall.
subset: goslim_pir
subset: gosubset_prok
synonym: "cell associated" EXACT []
synonym: "cell bound" EXACT []
is_a: GO:0044464 ! cell part

[Term]
id: GO:0009987
name: cellular process
namespace: biological_process
alt_id: GO:0008151
alt_id: GO:0050875
def: "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "cell growth and/or maintenance" NARROW []
synonym: "cell physiology" EXACT []
synonym: "cellular physiological process" EXACT []
is_a: GO:0008150 ! biological_process
disjoint_from: GO:0044848 ! biological phase

[Term]
id: GO:0009988
name: cell-cell recognition
namespace: biological_process
def: "Cell recognition between cells. May involve the formation of specialized cell junctions." [ISBN:0824072820]
is_a: GO:0008037 ! cell recognition

[Term]
id: GO:0009989
name: cell-matrix recognition
namespace: biological_process
def: "Cell recognition that involves the interaction of the cell with the extracellular matrix." [ISBN:0824072820]
is_a: GO:0008037 ! cell recognition

[Term]
id: GO:0009990
name: contact guidance
namespace: biological_process
def: "Cell recognition involving the deposition of specific pathways in the extracellular matrix that guide migrating cells." [ISBN:0824072820]
is_a: GO:0009989 ! cell-matrix recognition

[Term]
id: GO:0009991
name: response to extracellular stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus." [GOC:go_curators]
subset: goslim_plant
subset: gosubset_prok
is_a: GO:0009605 ! response to external stimulus

[Term]
id: GO:0009992
name: cellular water homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of water within a cell." [GOC:dph, GOC:tb]
synonym: "cellular osmoregulation" RELATED [GOC:dph, GOC:tb]
is_a: GO:0006884 ! cell volume homeostasis
is_a: GO:0030104 ! water homeostasis
is_a: GO:0055082 ! cellular chemical homeostasis

[Term]
id: GO:0009994
name: oocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete." [GOC:go_curators, GOC:mtg_sensu]
synonym: "oocyte cell differentiation" EXACT []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0048477 ! oogenesis

[Term]
id: GO:0009995
name: soluble molecule recognition
namespace: biological_process
def: "The recognition of soluble molecules in the environment." [GOC:go_curators]
is_a: GO:0009593 ! detection of chemical stimulus

[Term]
id: GO:0009996
name: negative regulation of cell fate specification
namespace: biological_process
def: "Any process that restricts, stops or prevents a cell from adopting a specific cell fate." [GOC:go_curators]
synonym: "down regulation of cell fate specification" EXACT []
synonym: "down-regulation of cell fate specification" EXACT []
synonym: "downregulation of cell fate specification" EXACT []
synonym: "inhibition of cell fate specification" NARROW []
synonym: "suppression of cell fate" EXACT []
is_a: GO:0010454 ! negative regulation of cell fate commitment
is_a: GO:0042659 ! regulation of cell fate specification
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001708 ! cell fate specification
relationship: negatively_regulates GO:0001708 ! cell fate specification

[Term]
id: GO:0009997
name: negative regulation of cardioblast cell fate specification
namespace: biological_process
alt_id: GO:0042687
def: "Any process that restricts, stops or prevents a cell from specifying into a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators]
synonym: "down regulation of cardioblast cell fate specification" EXACT []
synonym: "down-regulation of cardioblast cell fate specification" EXACT []
synonym: "downregulation of cardioblast cell fate specification" EXACT []
synonym: "inhibition of cardioblast cell fate specification" NARROW []
synonym: "suppression of cardioblast cell fate" EXACT []
is_a: GO:0042686 ! regulation of cardioblast cell fate specification
is_a: GO:0051892 ! negative regulation of cardioblast differentiation
is_a: GO:2000044 ! negative regulation of cardiac cell fate specification
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042685 ! cardioblast cell fate specification
relationship: negatively_regulates GO:0042685 ! cardioblast cell fate specification

[Term]
id: GO:0009998
name: negative regulation of retinal cone cell fate specification
namespace: biological_process
def: "Any process that restricts, stops or prevents a cell from specifying into a retinal cone cell." [GOC:go_curators]
synonym: "down regulation of retinal cone cell fate specification" EXACT []
synonym: "down-regulation of retinal cone cell fate specification" EXACT []
synonym: "downregulation of retinal cone cell fate specification" EXACT []
synonym: "inhibition of retinal cone cell fate specification" NARROW []
synonym: "negative regulation of retina cone cell fate specification" EXACT []
synonym: "suppression of retina cone cell fate" EXACT []
synonym: "suppression of retinal cone cell fate" EXACT []
is_a: GO:0009996 ! negative regulation of cell fate specification
is_a: GO:0042673 ! regulation of retinal cone cell fate specification
is_a: GO:0060226 ! negative regulation of retinal cone cell fate commitment
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042672 ! retinal cone cell fate specification
relationship: negatively_regulates GO:0042672 ! retinal cone cell fate specification

[Term]
id: GO:0009999
name: negative regulation of auditory receptor cell fate specification
namespace: biological_process
def: "Any process that restricts, stops or prevents a cell from specifying into an auditory hair cell." [GOC:go_curators]
synonym: "down regulation of auditory receptor cell fate specification" EXACT []
synonym: "down-regulation of auditory receptor cell fate specification" EXACT []
synonym: "downregulation of auditory receptor cell fate specification" EXACT []
synonym: "inhibition of auditory receptor cell fate specification" NARROW []
synonym: "negative regulation of auditory hair cell fate specification" EXACT []
synonym: "suppression of auditory receptor cell fate" EXACT []
synonym: "suppression of hair cell fate" EXACT []
is_a: GO:0009996 ! negative regulation of cell fate specification
is_a: GO:0042669 ! regulation of auditory receptor cell fate specification
is_a: GO:0045608 ! negative regulation of auditory receptor cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042667 ! auditory receptor cell fate specification
relationship: negatively_regulates GO:0042667 ! auditory receptor cell fate specification

[Term]
id: GO:0010001
name: glial cell differentiation
namespace: biological_process
alt_id: GO:0007404
alt_id: GO:0043360
def: "The process in which a relatively unspecialized cell acquires the specialized features of a glial cell." [GOC:go_curators, GOC:mtg_sensu]
synonym: "glia cell differentiation" EXACT []
synonym: "neuroglia differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0042063 ! gliogenesis

[Term]
id: GO:0010002
name: cardioblast differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators]
synonym: "cardiac precursor cell differentiation" EXACT [GOC:mtg_heart]
synonym: "cardioblast cell differentiation" EXACT []
synonym: "cardiomyocyte generation" RELATED []
is_a: GO:0035051 ! cardiocyte differentiation
is_a: GO:0048863 ! stem cell differentiation

[Term]
id: GO:0010004
name: gastrulation involving germ band extension
namespace: biological_process
def: "A complex and coordinated series of cellular movements, including germ band extension, that occurs at the end of cleavage during embryonic development. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
is_a: GO:0001703 ! gastrulation with mouth forming first

[Term]
id: GO:0010005
name: cortical microtubule, transverse to long axis
namespace: cellular_component
def: "Arrays of microtubules underlying and connected to the plasma membrane, in the cortical cytosol, oriented mainly with their axes transverse to the long axis of the cell (and root in plants). In plants it influences the direction of cellulose microfibril deposition." [ISBN:0943088399]
is_a: GO:0055028 ! cortical microtubule

[Term]
id: GO:0010006
name: Toc complex
namespace: cellular_component
def: "Protein translocon complex at the chloroplast outer membrane." [PMID:10646606]
is_a: GO:0044434 ! chloroplast part
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0009707 ! chloroplast outer membrane

[Term]
id: GO:0010007
name: magnesium chelatase complex
namespace: cellular_component
def: "A heterotrimeric enzyme complex composed of three subunits, all of which are required for enzyme activity, which catalyzes the chelation of Mg by proto IX in an ATP-dependent manner." [PMID:11842180]
is_a: GO:0044434 ! chloroplast part
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0010008
name: endosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding an endosome." [GOC:mah]
synonym: "endosomal membrane" EXACT [NIF_Subcellular:sao978443756]
xref: NIF_Subcellular:sao978443756
is_a: GO:0005774 ! vacuolar membrane
is_a: GO:0044440 ! endosomal part

[Term]
id: GO:0010009
name: cytoplasmic side of endosome membrane
namespace: cellular_component
def: "The side (leaflet) of the endosome membrane that faces the cytoplasm." [GOC:lr]
synonym: "external leaflet of endosome membrane" EXACT [GOC:ab]
synonym: "external side of endosome membrane" EXACT []
is_a: GO:0044440 ! endosomal part
is_a: GO:0098562 ! cytoplasmic side of membrane
relationship: part_of GO:0010008 ! endosome membrane

[Term]
id: GO:0010011
name: auxin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with auxin, plant hormones that regulate aspects of plant growth." [GOC:sm]
synonym: "auxin receptor" NARROW []
is_a: GO:0042562 ! hormone binding

[Term]
id: GO:0010012
name: steroid 22-alpha hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-alpha-campestanaol + O2 = 6-deoxocathasterone + H2O." [GOC:tb]
is_a: GO:0008395 ! steroid hydroxylase activity

[Term]
id: GO:0010013
name: N-1-naphthylphthalamic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with N-1-naphthylphthalamic acid, an auxin transport inhibitor." [GOC:sm]
is_a: GO:0008144 ! drug binding
is_a: GO:0033218 ! amide binding
is_a: GO:0033293 ! monocarboxylic acid binding
is_a: GO:0097159 ! organic cyclic compound binding

[Term]
id: GO:0010014
name: meristem initiation
namespace: biological_process
def: "Initiation of a region of tissue in a plant that is composed of one or more undifferentiated cells capable of undergoing mitosis and differentiation, thereby effecting growth and development of a plant by giving rise to more meristem or specialized tissue." [GOC:sm]
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0009933 ! meristem structural organization

[Term]
id: GO:0010015
name: root morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of roots are generated and organized. The root is the usually underground part of a seed plant body that originates from the hypocotyl, functions as an organ of absorption, aeration, and food storage or as a means of anchorage and support." [GOC:sm, ISBN:0877797099]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0048364 ! root development

[Term]
id: GO:0010016
name: shoot system morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the shoot are generated and organized. The shoot is the part of a seed plant body that is usually above ground." [GOC:sm, ISBN:0877797099]
synonym: "shoot morphogenesis" EXACT []
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0048367 ! shoot system development

[Term]
id: GO:0010017
name: red or far-red light signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated upon sensing by photoreceptor molecules of red light or far red light. Red light is electromagnetic radiation of wavelength of 580-700nm. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:lr, GOC:mtg_far_red, GOC:sm]
synonym: "phytochrome signaling pathway" BROAD []
synonym: "red or far red light signaling pathway" EXACT [GOC:bf, GOC:tb]
synonym: "red or far-red light signal transduction" EXACT [GOC:signaling]
synonym: "red or far-red light signalling pathway" EXACT []
synonym: "red/far red light signaling pathway" EXACT []
is_a: GO:0007165 ! signal transduction
is_a: GO:0071489 ! cellular response to red or far red light

[Term]
id: GO:0010018
name: far-red light signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated upon sensing of far red light by a photoreceptor molecule. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:lr, GOC:mtg_far_red, GOC:sm]
synonym: "far red light signalling pathway" EXACT []
synonym: "far red signaling pathway" EXACT [GOC:tb]
synonym: "far-red light signal transduction" EXACT [GOC:signaling]
is_a: GO:0010017 ! red or far-red light signaling pathway
is_a: GO:0071490 ! cellular response to far red light

[Term]
id: GO:0010019
name: chloroplast-nucleus signaling pathway
namespace: biological_process
def: "The process in which a molecular signal is transduced between the chloroplast and nucleus, such that expression of nuclear encoding photosynthetic proteins is coupled with chloroplast biogenesis." [PMID:8972595]
synonym: "chloroplast-nucleus signalling pathway" EXACT []
is_a: GO:0007165 ! signal transduction

[Term]
id: GO:0010020
name: chloroplast fission
namespace: biological_process
def: "The division of a chloroplast within a cell to form two or more separate chloroplast compartments. This division occurs independently of mitosis." [GOC:lr]
synonym: "chloroplast division" EXACT []
is_a: GO:0009658 ! chloroplast organization
is_a: GO:0043572 ! plastid fission

[Term]
id: GO:0010021
name: amylopectin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of amylopectin, the (1->4) linked alpha glucose units with alpha-(1->6) linkages." [ISBN:0943088399]
subset: gosubset_prok
synonym: "amylopectin anabolism" EXACT []
synonym: "amylopectin biosynthesis" EXACT []
synonym: "amylopectin formation" EXACT []
synonym: "amylopectin synthesis" EXACT []
is_a: GO:0009059 ! macromolecule biosynthetic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process
is_a: GO:2000896 ! amylopectin metabolic process

[Term]
id: GO:0010022
name: meristem determinacy
namespace: biological_process
def: "The process in which a meristem becomes determinate (i.e. ceases to produce lateral organs and may or may not terminally differentiate)." [GOC:lr]
is_a: GO:0044707 ! single-multicellular organism process
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0010073 ! meristem maintenance

[Term]
id: GO:0010023
name: proanthocyanidin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of proanthocyanidin." [GOC:lm]
subset: gosubset_prok
synonym: "proanthocyanidin anabolism" EXACT []
synonym: "proanthocyanidin biosynthesis" EXACT []
synonym: "proanthocyanidin formation" EXACT []
synonym: "proanthocyanidin synthesis" EXACT []
xref: MetaCyc:PWY-641
is_a: GO:0009699 ! phenylpropanoid biosynthetic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process

[Term]
id: GO:0010024
name: phytochromobilin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phytochromobilin, which involves the oxidative cleavage of heme by a heme oxygenase(HO) to form biliverdin IX alpha." [PMID:11402195]
subset: gosubset_prok
synonym: "phytochromobilin anabolism" EXACT []
synonym: "phytochromobilin biosynthesis" EXACT []
synonym: "phytochromobilin formation" EXACT []
synonym: "phytochromobilin synthesis" EXACT []
is_a: GO:0033014 ! tetrapyrrole biosynthetic process
is_a: GO:0051188 ! cofactor biosynthetic process
is_a: GO:0051202 ! phytochromobilin metabolic process

[Term]
id: GO:0010025
name: wax biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of wax, which includes C16 and C18 fatty acids." [ISBN:0943088399]
subset: gosubset_prok
synonym: "wax anabolism" EXACT []
synonym: "wax biosynthesis" EXACT []
synonym: "wax formation" EXACT []
synonym: "wax synthesis" EXACT []
xref: MetaCyc:PWY-282
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0010166 ! wax metabolic process

[Term]
id: GO:0010026
name: trichome differentiation
namespace: biological_process
alt_id: GO:0048271
def: "The process in which a relatively unspecialized epidermal cell acquires the specialized features of a trichome cell. An example of this process is found in Arabidopsis thaliana." [GOC:mtg_sensu, PMID:9367433]
synonym: "trichome cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0090558 ! plant epidermis development

[Term]
id: GO:0010027
name: thylakoid membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the thylakoid membrane." [GOC:dph, GOC:jl, GOC:mah, GOC:tb]
comment: See also the cellular component term 'thylakoid membrane ; GO:0042651'.
synonym: "thylakoid membrane organisation" EXACT [GOC:curators]
synonym: "thylakoid membrane organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0009668 ! plastid membrane organization

[Term]
id: GO:0010028
name: xanthophyll cycle
namespace: biological_process
def: "A cyclic series of interconversions involving three xanthophylls, violoxanthin, antheraxanthin, and zeaxanthin. The xanthophyll cycle is involved in regulating energy dissipation in light harvesting complex II." [ISBN:0122146743]
subset: gosubset_prok
xref: MetaCyc:PWY-1141
xref: Wikipedia:Xanthophyll#Xanthophyll_cycle
is_a: GO:0016122 ! xanthophyll metabolic process

[Term]
id: GO:0010029
name: regulation of seed germination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of seed germination." [GOC:sm]
is_a: GO:1900140 ! regulation of seedling development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009845 ! seed germination
relationship: regulates GO:0009845 ! seed germination

[Term]
id: GO:0010030
name: positive regulation of seed germination
namespace: biological_process
def: "Any process that activates or increase the rate of seed germination." [GOC:sm]
synonym: "activation of seed germination" NARROW []
synonym: "stimulation of seed germination" NARROW []
synonym: "up regulation of seed germination" EXACT []
synonym: "up-regulation of seed germination" EXACT []
synonym: "upregulation of seed germination" EXACT []
is_a: GO:0010029 ! regulation of seed germination
is_a: GO:0048582 ! positive regulation of post-embryonic development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009845 ! seed germination
relationship: positively_regulates GO:0009845 ! seed germination

[Term]
id: GO:0010031
name: circumnutation
namespace: biological_process
def: "The organismal movement by which the tip of a plant organ follows a spiral pattern as a consequence of growth." [GOC:mtg_MIT_16mar07, ISBN:0192801023]
is_a: GO:0050879 ! multicellular organismal movement

[Term]
id: GO:0010032
name: meiotic chromosome condensation
namespace: biological_process
def: "Compaction of chromatin structure prior to meiosis in eukaryotic cells." [PMID:10072401]
synonym: "chromosome condensation involved in meiotic cell cycle" EXACT [GOC:dph, GOC:tb]
is_a: GO:0030261 ! chromosome condensation
is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle
intersection_of: GO:0030261 ! chromosome condensation
intersection_of: part_of GO:0051321 ! meiotic cell cycle
relationship: part_of GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0010033
name: response to organic substance
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus." [GOC:sm]
subset: gosubset_prok
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0010034
name: response to acetate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetate stimulus." [GOC:sm]
subset: gosubset_prok
is_a: GO:0001101 ! response to acid chemical
is_a: GO:0010033 ! response to organic substance
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0010035
name: response to inorganic substance
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus." [GOC:sm]
subset: gosubset_prok
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0010036
name: response to boron-containing substance
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a boron-containing substance stimulus." [GOC:sm]
synonym: "response to boron" EXACT [GOC:curators]
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0010037
name: response to carbon dioxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon dioxide (CO2) stimulus." [GOC:sm]
is_a: GO:0010033 ! response to organic substance
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0010038
name: response to metal ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:sm]
subset: gosubset_prok
synonym: "heavy metal sensitivity/resistance" RELATED []
synonym: "response to heavy metal" NARROW []
synonym: "response to metal" EXACT []
is_a: GO:0010035 ! response to inorganic substance

[Term]
id: GO:0010039
name: response to iron ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus." [GOC:sm]
synonym: "response to iron" EXACT []
is_a: GO:0010038 ! response to metal ion
is_a: GO:1990267 ! response to transition metal nanoparticle

[Term]
id: GO:0010040
name: response to iron(II) ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(II) ion stimulus." [GOC:sm]
synonym: "response to iron(II)" EXACT []
is_a: GO:0010039 ! response to iron ion

[Term]
id: GO:0010041
name: response to iron(III) ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(III) ion stimulus." [GOC:sm]
synonym: "response to iron(III)" EXACT []
is_a: GO:0010039 ! response to iron ion

[Term]
id: GO:0010042
name: response to manganese ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a manganese ion stimulus." [GOC:sm]
synonym: "response to manganese" EXACT []
is_a: GO:0010038 ! response to metal ion
is_a: GO:1990267 ! response to transition metal nanoparticle

[Term]
id: GO:0010043
name: response to zinc ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus." [GOC:sm]
synonym: "response to zinc" EXACT []
is_a: GO:0010038 ! response to metal ion
is_a: GO:1990267 ! response to transition metal nanoparticle

[Term]
id: GO:0010044
name: response to aluminum ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aluminum ion stimulus." [GOC:sm]
synonym: "response to aluminium ion" EXACT []
synonym: "response to aluminum" EXACT []
is_a: GO:0010038 ! response to metal ion

[Term]
id: GO:0010045
name: response to nickel cation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nickel cation stimulus." [GOC:sm]
synonym: "response to nickel" EXACT []
is_a: GO:0010038 ! response to metal ion

[Term]
id: GO:0010046
name: response to mycotoxin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mycotoxin stimulus. A mycotoxin is a toxic chemical substance produced by fungi." [GOC:sm]
is_a: GO:0009636 ! response to toxic substance

[Term]
id: GO:0010047
name: fruit dehiscence
namespace: biological_process
def: "The process leading to the spontaneous opening of the fruit permitting the escape of seeds." [GOC:tb, ISBN:0471245208]
is_a: GO:0009900 ! dehiscence

[Term]
id: GO:0010048
name: vernalization response
namespace: biological_process
def: "The process of thermal induction in plants in which flowering is promoted by exposure to low temperatures." [GOC:tair_curators, ISBN:0521591392]
is_a: GO:0009409 ! response to cold

[Term]
id: GO:0010049
name: acquisition of reproductive competence
namespace: biological_process
def: "The process in which a plant acquires the ability to respond to a floral inductive signal." [GOC:tair_curators]
is_a: GO:0009791 ! post-embryonic development

[Term]
id: GO:0010050
name: vegetative phase change
namespace: biological_process
def: "Any process involved in the transition of a plant from a juvenile phase of vegetative development to an adult phase of vegetative development." [GOC:tb]
is_a: GO:0009791 ! post-embryonic development

[Term]
id: GO:0010051
name: xylem and phloem pattern formation
namespace: biological_process
def: "The regionalization process that gives rise to the patterning of the conducting tissues. An example of this process is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tb]
synonym: "vascular tissue pattern formation" EXACT []
is_a: GO:0003002 ! regionalization

[Term]
id: GO:0010052
name: guard cell differentiation
namespace: biological_process
def: "The process in which a guard mother cell acquires the specialized features of a guard cell." [GOC:expert_db, GOC:tb]
synonym: "stomatal cell differentiation" RELATED []
is_a: GO:0090627 ! plant epidermal cell differentiation
relationship: part_of GO:0010103 ! stomatal complex morphogenesis

[Term]
id: GO:0010053
name: root epidermal cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell in the root epidermis acquires the specialized features of a trichoblast or atrichoblast." [GOC:tb]
is_a: GO:0090627 ! plant epidermal cell differentiation
relationship: part_of GO:0010015 ! root morphogenesis
relationship: part_of GO:0090558 ! plant epidermis development

[Term]
id: GO:0010054
name: trichoblast differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a trichoblast, a root epidermal cell that will give rise to a root hair." [GOC:tb]
synonym: "trichoblast cell differentiation" EXACT []
is_a: GO:0010053 ! root epidermal cell differentiation

[Term]
id: GO:0010055
name: atrichoblast differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of an atrichoblast, a root epidermal cell that will not give rise to a root hair." [GOC:tb]
is_a: GO:0010053 ! root epidermal cell differentiation

[Term]
id: GO:0010056
name: atrichoblast fate specification
namespace: biological_process
def: "The process involved in the specification of an atrichoblast." [GOC:tb]
is_a: GO:0090628 ! plant epidermal cell fate specification
relationship: part_of GO:0010055 ! atrichoblast differentiation

[Term]
id: GO:0010057
name: trichoblast fate specification
namespace: biological_process
def: "The process involved in the specification of a trichoblast." [GOC:tb]
is_a: GO:0090628 ! plant epidermal cell fate specification
relationship: part_of GO:0010054 ! trichoblast differentiation

[Term]
id: GO:0010058
name: regulation of atrichoblast fate specification
namespace: biological_process
def: "Any process that modulates atrichoblast fate specification." [GOC:tb]
is_a: GO:0042659 ! regulation of cell fate specification
is_a: GO:1903888 ! regulation of plant epidermal cell differentiation
is_a: GO:2000067 ! regulation of root morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010056 ! atrichoblast fate specification
relationship: regulates GO:0010056 ! atrichoblast fate specification

[Term]
id: GO:0010059
name: positive regulation of atrichoblast fate specification
namespace: biological_process
def: "Any process that induces or promotes atrichoblast fate specification." [GOC:tb]
synonym: "activation of atrichoblast fate" NARROW []
synonym: "stimulation of atrichoblast fate" NARROW []
synonym: "up regulation of atrichoblast fate" EXACT []
synonym: "up-regulation of atrichoblast fate" EXACT []
synonym: "upregulation of atrichoblast fate" EXACT []
is_a: GO:0010058 ! regulation of atrichoblast fate specification
is_a: GO:0042660 ! positive regulation of cell fate specification
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1903890 ! positive regulation of plant epidermal cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010056 ! atrichoblast fate specification
relationship: positively_regulates GO:0010056 ! atrichoblast fate specification

[Term]
id: GO:0010060
name: negative regulation of atrichoblast fate specification
namespace: biological_process
def: "Any process that suppresses atrichoblast fate specification." [GOC:tb]
synonym: "down regulation of atrichoblast fate" EXACT []
synonym: "down-regulation of atrichoblast fate" EXACT []
synonym: "downregulation of atrichoblast fate" EXACT []
synonym: "inhibition of atrichoblast fate" NARROW []
is_a: GO:0009996 ! negative regulation of cell fate specification
is_a: GO:0010058 ! regulation of atrichoblast fate specification
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1903889 ! negative regulation of plant epidermal cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010056 ! atrichoblast fate specification
relationship: negatively_regulates GO:0010056 ! atrichoblast fate specification

[Term]
id: GO:0010061
name: regulation of trichoblast fate specification
namespace: biological_process
def: "Any process that modulates trichoblast fate specification." [GOC:tb]
is_a: GO:0042659 ! regulation of cell fate specification
is_a: GO:1903888 ! regulation of plant epidermal cell differentiation
is_a: GO:2000067 ! regulation of root morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010057 ! trichoblast fate specification
relationship: regulates GO:0010057 ! trichoblast fate specification

[Term]
id: GO:0010062
name: negative regulation of trichoblast fate specification
namespace: biological_process
def: "Any process that suppresses trichoblast fate specification." [GOC:tb]
synonym: "down regulation of trichoblast fate" EXACT []
synonym: "down-regulation of trichoblast fate" EXACT []
synonym: "downregulation of trichoblast fate" EXACT []
synonym: "inhibition of trichoblast fate" NARROW []
is_a: GO:0009996 ! negative regulation of cell fate specification
is_a: GO:0010061 ! regulation of trichoblast fate specification
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1903889 ! negative regulation of plant epidermal cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010057 ! trichoblast fate specification
relationship: negatively_regulates GO:0010057 ! trichoblast fate specification

[Term]
id: GO:0010063
name: positive regulation of trichoblast fate specification
namespace: biological_process
def: "Any process that induces or promotes trichoblast fate specification." [GOC:tb]
synonym: "activation of trichoblast fate" NARROW []
synonym: "stimulation of trichoblast fate" NARROW []
synonym: "up regulation of trichoblast fate" EXACT []
synonym: "up-regulation of trichoblast fate" EXACT []
synonym: "upregulation of trichoblast fate" EXACT []
is_a: GO:0010061 ! regulation of trichoblast fate specification
is_a: GO:0042660 ! positive regulation of cell fate specification
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1903890 ! positive regulation of plant epidermal cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010057 ! trichoblast fate specification
relationship: positively_regulates GO:0010057 ! trichoblast fate specification

[Term]
id: GO:0010064
name: embryonic shoot morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of embryonic shoot are generated and organized." [GOC:tb]
synonym: "primary shoot system morphogenesis" EXACT []
is_a: GO:0010016 ! shoot system morphogenesis
is_a: GO:0048598 ! embryonic morphogenesis

[Term]
id: GO:0010065
name: primary meristem tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of the primary meristem over time, from formation to the mature structure, as it occurs during plant embryogenesis. The primary meristem tissue is the protoderm, ground meristem and procambium." [GOC:tb, ISBN:0471245208]
synonym: "primary meristem histogenesis" EXACT []
is_a: GO:0048508 ! embryonic meristem development

[Term]
id: GO:0010066
name: ground meristem histogenesis
namespace: biological_process
def: "The formation of the primary meristem or meristematic tissue that gives rise to the ground tissues." [GOC:tb, ISBN:0471245208]
is_a: GO:0010065 ! primary meristem tissue development

[Term]
id: GO:0010067
name: procambium histogenesis
namespace: biological_process
def: "The formation of the primary meristem or meristematic tissue that gives rise to the primary vascular tissue." [GOC:tb, ISBN:0471245208]
is_a: GO:0010065 ! primary meristem tissue development

[Term]
id: GO:0010068
name: protoderm histogenesis
namespace: biological_process
def: "The formation of the primary meristem or meristematic tissue that gives rise to the epidermis." [GOC:tb, ISBN:0471245208]
is_a: GO:0010065 ! primary meristem tissue development

[Term]
id: GO:0010069
name: zygote asymmetric cytokinesis in embryo sac
namespace: biological_process
def: "The division of the zygote in a plane perpendicular to the long axis of the embryo sac to produce a larger basal cell near the micropyle and a small terminal cell close to what was the central cell and is now the developing endosperm. An example of this process is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tb, ISBN:0865427429]
is_a: GO:0000281 ! mitotic cytokinesis
is_a: GO:0010070 ! zygote asymmetric cell division
is_a: GO:0044702 ! single organism reproductive process
relationship: part_of GO:0009793 ! embryo development ending in seed dormancy

[Term]
id: GO:0010070
name: zygote asymmetric cell division
namespace: biological_process
def: "The division of the zygote into two daughter cells that will adopt developmentally distinct potentials." [GOC:tb]
synonym: "zygote asymmetric cytokinesis" RELATED []
is_a: GO:0008356 ! asymmetric cell division

[Term]
id: GO:0010071
name: root meristem specification
namespace: biological_process
def: "The specification of a meristem which will give rise to a primary or lateral root." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0090421 ! embryonic meristem initiation
relationship: part_of GO:0010015 ! root morphogenesis
relationship: part_of GO:0048508 ! embryonic meristem development

[Term]
id: GO:0010072
name: primary shoot apical meristem specification
namespace: biological_process
def: "The specification of the meristem which will give rise to all post-embryonic above-ground structures of the plant as well as the non-root below-ground structures, such as rhizomes and tubers." [GOC:ascb_2009, GOC:dph, GOC:tair_curators, GOC:tb]
synonym: "embryo shoot apical meristem specification" EXACT []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0090421 ! embryonic meristem initiation
relationship: part_of GO:0010016 ! shoot system morphogenesis
relationship: part_of GO:0048508 ! embryonic meristem development

[Term]
id: GO:0010073
name: meristem maintenance
namespace: biological_process
def: "Any process involved in maintaining the identity, size and shape of a meristem." [GOC:tb]
is_a: GO:0044707 ! single-multicellular organism process
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0048507 ! meristem development

[Term]
id: GO:0010074
name: maintenance of meristem identity
namespace: biological_process
alt_id: GO:0032503
def: "The process in which an organism retains a population of meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:tb]
synonym: "maintenance of meristem cell identity" EXACT []
synonym: "meristem cell maintenance" EXACT []
is_a: GO:0019827 ! stem cell population maintenance
relationship: part_of GO:0010073 ! meristem maintenance

[Term]
id: GO:0010075
name: regulation of meristem growth
namespace: biological_process
def: "Any process involved in maintaining the size and shape of a meristem." [GOC:tb]
synonym: "regulation of meristem size" EXACT [GOC:tb]
is_a: GO:0048509 ! regulation of meristem development
is_a: GO:0048638 ! regulation of developmental growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035266 ! meristem growth
relationship: part_of GO:0010073 ! meristem maintenance
relationship: regulates GO:0035266 ! meristem growth

[Term]
id: GO:0010076
name: maintenance of floral meristem identity
namespace: biological_process
def: "The process in which an organism retains a population of floral meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:dph, GOC:tb]
is_a: GO:0010074 ! maintenance of meristem identity

[Term]
id: GO:0010077
name: maintenance of inflorescence meristem identity
namespace: biological_process
def: "The process in which an organism retains a population of inflorescence meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:dph, GOC:tb]
is_a: GO:0010074 ! maintenance of meristem identity

[Term]
id: GO:0010078
name: maintenance of root meristem identity
namespace: biological_process
def: "The process in which an organism retains a population of root meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:dph, GOC:tb]
is_a: GO:0010074 ! maintenance of meristem identity
relationship: part_of GO:0010015 ! root morphogenesis

[Term]
id: GO:0010079
name: maintenance of vegetative meristem identity
namespace: biological_process
def: "The process in which an organism retains a population of vegetative meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:dph, GOC:tb]
is_a: GO:0010074 ! maintenance of meristem identity

[Term]
id: GO:0010080
name: regulation of floral meristem growth
namespace: biological_process
def: "Any process involved in maintaining the size and shape of a floral meristem." [GOC:tb]
synonym: "regulation of floral meristem size" EXACT []
is_a: GO:0009909 ! regulation of flower development
is_a: GO:0010075 ! regulation of meristem growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010451 ! floral meristem growth
relationship: regulates GO:0010451 ! floral meristem growth

[Term]
id: GO:0010081
name: regulation of inflorescence meristem growth
namespace: biological_process
def: "Any process involved in maintaining the size and shape of an inflorescence meristem." [GOC:tb]
synonym: "regulation of inflorescence meristem size" EXACT [GOC:tb]
is_a: GO:0010075 ! regulation of meristem growth
is_a: GO:0048580 ! regulation of post-embryonic development
is_a: GO:0048831 ! regulation of shoot system development
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010450 ! inflorescence meristem growth
relationship: regulates GO:0010450 ! inflorescence meristem growth

[Term]
id: GO:0010082
name: regulation of root meristem growth
namespace: biological_process
def: "Any process involved in maintaining the size and shape of a root meristem." [GOC:tb]
synonym: "regulation of root meristem size" EXACT [GOC:tb]
is_a: GO:0010075 ! regulation of meristem growth
is_a: GO:2000280 ! regulation of root development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010449 ! root meristem growth
relationship: part_of GO:0010015 ! root morphogenesis
relationship: regulates GO:0010449 ! root meristem growth

[Term]
id: GO:0010083
name: regulation of vegetative meristem growth
namespace: biological_process
def: "Any process involved in maintaining the size and shape of a vegetative meristem." [GOC:tb]
synonym: "regulation of vegetative meristem size" EXACT [GOC:tb]
is_a: GO:0010075 ! regulation of meristem growth
is_a: GO:0048831 ! regulation of shoot system development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010448 ! vegetative meristem growth
relationship: regulates GO:0010448 ! vegetative meristem growth

[Term]
id: GO:0010084
name: specification of organ axis polarity
namespace: biological_process
def: "The process in which the polarity of an organ axis is specified." [GOC:tb]
is_a: GO:0065001 ! specification of axis polarity
relationship: part_of GO:0009887 ! organ morphogenesis

[Term]
id: GO:0010085
name: polarity specification of proximal/distal axis
namespace: biological_process
def: "Any process resulting in the establishment of polarity along the proximal/distal axis." [GOC:tb]
is_a: GO:0065001 ! specification of axis polarity
relationship: part_of GO:0009946 ! proximal/distal axis specification

[Term]
id: GO:0010086
name: embryonic root morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the embryonic root are generated and organized." [GOC:tb]
is_a: GO:0010015 ! root morphogenesis
is_a: GO:0048598 ! embryonic morphogenesis

[Term]
id: GO:0010087
name: phloem or xylem histogenesis
namespace: biological_process
def: "The process whose specific outcome is the progression of phloem and/or xylem over time, from formation to the mature structure. An example of this process is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tb]
synonym: "vascular tissue development" BROAD []
synonym: "vascular tissue histogenesis" EXACT []
is_a: GO:0009888 ! tissue development

[Term]
id: GO:0010088
name: phloem development
namespace: biological_process
def: "The formation of the principal food-conducting tissue of a vascular plant." [GOC:tb, ISBN:0471245208]
synonym: "phloem histogenesis" EXACT [GOC:tb]
is_a: GO:0010087 ! phloem or xylem histogenesis

[Term]
id: GO:0010089
name: xylem development
namespace: biological_process
def: "The formation of the principal water-conducting tissue of a vascular plant." [GOC:tb, ISBN:0471245208]
synonym: "xylem histogenesis" EXACT [GOC:tb]
is_a: GO:0010087 ! phloem or xylem histogenesis

[Term]
id: GO:0010090
name: trichome morphogenesis
namespace: biological_process
alt_id: GO:0048272
def: "The process in which the structures of a hair cell (trichome) cell are generated and organized. This process occurs while the initially relatively unspecialized epidermal cell is acquiring the specialized features of a hair cell. An example of this process is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tair_curators]
synonym: "trichome cell morphogenesis during differentiation" EXACT []
is_a: GO:0000904 ! cell morphogenesis involved in differentiation
relationship: part_of GO:0010026 ! trichome differentiation
relationship: part_of GO:0090626 ! plant epidermis morphogenesis

[Term]
id: GO:0010091
name: trichome branching
namespace: biological_process
alt_id: GO:0048274
def: "Any process involved in the formation of branches in plant hair cells. An example of this process is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tair_curators]
is_a: GO:0000904 ! cell morphogenesis involved in differentiation
relationship: part_of GO:0010090 ! trichome morphogenesis

[Term]
id: GO:0010092
name: specification of organ identity
namespace: biological_process
def: "The regionalization process in which the identity of an organ primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tair_curators]
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0048645 ! organ formation

[Term]
id: GO:0010093
name: specification of floral organ identity
namespace: biological_process
def: "The process in which the identity of a floral organ primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tb]
is_a: GO:0003002 ! regionalization
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
relationship: part_of GO:0048449 ! floral organ formation

[Term]
id: GO:0010094
name: specification of carpel identity
namespace: biological_process
def: "The process in which a floral organ primordium acquires the carpel identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tair_curators]
is_a: GO:0010093 ! specification of floral organ identity
relationship: part_of GO:0048462 ! carpel formation

[Term]
id: GO:0010095
name: specification of petal identity
namespace: biological_process
def: "The process in which a floral organ primordium acquires petal identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tair_curators]
is_a: GO:0010093 ! specification of floral organ identity
relationship: part_of GO:0048451 ! petal formation

[Term]
id: GO:0010096
name: specification of sepal identity
namespace: biological_process
def: "The process in which a floral organ primordium acquires sepal identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tair_curators]
is_a: GO:0010093 ! specification of floral organ identity
relationship: part_of GO:0048453 ! sepal formation

[Term]
id: GO:0010097
name: specification of stamen identity
namespace: biological_process
def: "The process in which a floral organ primordium acquires stamen or staminode identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tair_curators]
is_a: GO:0010093 ! specification of floral organ identity
relationship: part_of GO:0048455 ! stamen formation

[Term]
id: GO:0010098
name: suspensor development
namespace: biological_process
def: "The process whose specific outcome is the progression of the suspensor over time, from its formation to the mature structure. The suspensor is the extension at the base of the embryo that anchors the embryo in the embryo sac and pushes it into the endosperm." [GOC:tb, ISBN:0471245208]
is_a: GO:0048856 ! anatomical structure development

[Term]
id: GO:0010099
name: regulation of photomorphogenesis
namespace: biological_process
def: "Any process that modulates the rate or extent of photomorphogenesis." [GOC:tb]
is_a: GO:0048580 ! regulation of post-embryonic development
is_a: GO:2000030 ! regulation of response to red or far red light
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009640 ! photomorphogenesis
relationship: regulates GO:0009640 ! photomorphogenesis

[Term]
id: GO:0010100
name: negative regulation of photomorphogenesis
namespace: biological_process
def: "Any process that stops, reduces or prevents photomorphogenesis." [GOC:tb]
synonym: "down regulation of photomorphogenesis" EXACT []
synonym: "down-regulation of photomorphogenesis" EXACT []
synonym: "downregulation of photomorphogenesis" EXACT []
synonym: "inhibition of photomorphogenesis" NARROW []
is_a: GO:0010099 ! regulation of photomorphogenesis
is_a: GO:0048581 ! negative regulation of post-embryonic development
is_a: GO:0048585 ! negative regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009640 ! photomorphogenesis
relationship: negatively_regulates GO:0009640 ! photomorphogenesis

[Term]
id: GO:0010101
name: post-embryonic root morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the post-embryonic root are generated and organized. The post-embryonic root is the root formed after the embryonic phase has been completed." [GOC:tb]
is_a: GO:0009886 ! post-embryonic morphogenesis
is_a: GO:0010015 ! root morphogenesis
relationship: part_of GO:0048528 ! post-embryonic root development

[Term]
id: GO:0010102
name: lateral root morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a lateral root are generated and organized. A lateral root is one formed from pericycle cells located on the xylem radius of the root, as opposed to the initiation of the main root from the embryo proper." [GOC:tair_curators]
is_a: GO:0010101 ! post-embryonic root morphogenesis
relationship: part_of GO:0048527 ! lateral root development

[Term]
id: GO:0010103
name: stomatal complex morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the stomatal complex are generated and organized. The stomatal complex is the stomatal guard cells and their associated epidermal cells." [GOC:tair_curators]
is_a: GO:0009886 ! post-embryonic morphogenesis
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0090626 ! plant epidermis morphogenesis
relationship: part_of GO:0010016 ! shoot system morphogenesis
relationship: part_of GO:0010374 ! stomatal complex development

[Term]
id: GO:0010104
name: regulation of ethylene-activated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ethylene (ethene) signal transduction." [GOC:tb]
synonym: "regulation of ethene mediated signaling pathway" EXACT []
synonym: "regulation of ethene mediated signalling pathway" EXACT []
synonym: "regulation of ethylene mediated signaling pathway" RELATED []
synonym: "regulation of ethylene mediated signalling pathway" EXACT []
is_a: GO:0070297 ! regulation of phosphorelay signal transduction system
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009873 ! ethylene-activated signaling pathway
relationship: regulates GO:0009873 ! ethylene-activated signaling pathway

[Term]
id: GO:0010105
name: negative regulation of ethylene-activated signaling pathway
namespace: biological_process
def: "Any process that stops or prevents ethylene (ethene) signal transduction." [GOC:tb]
synonym: "down regulation of ethylene mediated signaling pathway" EXACT []
synonym: "down-regulation of ethylene mediated signaling pathway" EXACT []
synonym: "downregulation of ethylene mediated signaling pathway" EXACT []
synonym: "inhibition of ethylene mediated signaling pathway" NARROW []
synonym: "negative regulation of ethene mediated signaling pathway" EXACT []
synonym: "negative regulation of ethene mediated signalling pathway" EXACT []
synonym: "negative regulation of ethylene mediated signaling pathway" RELATED []
synonym: "negative regulation of ethylene mediated signalling pathway" EXACT []
is_a: GO:0010104 ! regulation of ethylene-activated signaling pathway
is_a: GO:0070298 ! negative regulation of phosphorelay signal transduction system
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009873 ! ethylene-activated signaling pathway
relationship: negatively_regulates GO:0009873 ! ethylene-activated signaling pathway

[Term]
id: GO:0010106
name: cellular response to iron ion starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of iron ions." [GOC:mg]
is_a: GO:0009267 ! cellular response to starvation

[Term]
id: GO:0010107
name: potassium ion import
namespace: biological_process
def: "The directed movement of potassium ions into a cell or organelle." [GOC:sm]
synonym: "potassium import" EXACT []
synonym: "potassium ion uptake" EXACT [GOC:dph, GOC:tb]
is_a: GO:0071805 ! potassium ion transmembrane transport

[Term]
id: GO:0010108
name: detection of glutamine
namespace: biological_process
def: "The series of events in which a glutamine stimulus is received by a cell and converted into a molecular signal." [GOC:sm]
synonym: "glutamine detection" EXACT []
synonym: "glutamine perception" RELATED []
synonym: "glutamine sensing" RELATED []
is_a: GO:0009593 ! detection of chemical stimulus

[Term]
id: GO:0010109
name: regulation of photosynthesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of photosynthesis." [GOC:sm]
subset: gosubset_prok
is_a: GO:0031323 ! regulation of cellular metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0015979 ! photosynthesis
relationship: regulates GO:0015979 ! photosynthesis

[Term]
id: GO:0010110
name: regulation of photosynthesis, dark reaction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of photosynthesis dark reaction." [GOC:sm]
is_a: GO:0010109 ! regulation of photosynthesis
is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019685 ! photosynthesis, dark reaction
relationship: regulates GO:0019685 ! photosynthesis, dark reaction

[Term]
id: GO:0010111
name: glyoxysome organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the glyoxysome. A glyoxysome is a microbody that contains the enzymes of the glyoxylate pathway." [GOC:tb]
synonym: "glyoxysome organisation" EXACT [GOC:curators]
synonym: "glyoxysome organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0007031 ! peroxisome organization
is_a: GO:0009657 ! plastid organization

[Term]
id: GO:0010112
name: regulation of systemic acquired resistance
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of systemic acquired resistance." [GOC:sm]
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0032101 ! regulation of response to external stimulus
is_a: GO:0043900 ! regulation of multi-organism process
is_a: GO:0045088 ! regulation of innate immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009627 ! systemic acquired resistance
relationship: regulates GO:0009627 ! systemic acquired resistance

[Term]
id: GO:0010113
name: negative regulation of systemic acquired resistance
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of systemic acquired resistance." [GOC:sm]
synonym: "down regulation of systemic acquired resistance" EXACT []
synonym: "down-regulation of systemic acquired resistance" EXACT []
synonym: "downregulation of systemic acquired resistance" EXACT []
synonym: "inhibition of systemic acquired resistance" NARROW []
is_a: GO:0002832 ! negative regulation of response to biotic stimulus
is_a: GO:0010112 ! regulation of systemic acquired resistance
is_a: GO:0032102 ! negative regulation of response to external stimulus
is_a: GO:0043901 ! negative regulation of multi-organism process
is_a: GO:0045824 ! negative regulation of innate immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009627 ! systemic acquired resistance
relationship: negatively_regulates GO:0009627 ! systemic acquired resistance

[Term]
id: GO:0010114
name: response to red light
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:mtg_far_red, GOC:sm]
synonym: "response to red light stimulus" EXACT []
is_a: GO:0009639 ! response to red or far red light

[Term]
id: GO:0010115
name: regulation of abscisic acid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of abscisic acid." [GOC:sm]
subset: gosubset_prok
synonym: "regulation of abscisic acid anabolism" EXACT []
synonym: "regulation of abscisic acid biosynthesis" EXACT []
synonym: "regulation of abscisic acid formation" EXACT []
synonym: "regulation of abscisic acid synthesis" EXACT []
is_a: GO:0010565 ! regulation of cellular ketone metabolic process
is_a: GO:0019747 ! regulation of isoprenoid metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0043455 ! regulation of secondary metabolic process
is_a: GO:0046890 ! regulation of lipid biosynthetic process
is_a: GO:1902930 ! regulation of alcohol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009688 ! abscisic acid biosynthetic process
relationship: regulates GO:0009688 ! abscisic acid biosynthetic process

[Term]
id: GO:0010116
name: positive regulation of abscisic acid biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of abscisic acid." [GOC:sm]
subset: gosubset_prok
synonym: "activation of abscisic acid biosynthetic process" NARROW []
synonym: "positive regulation of abscisic acid anabolism" EXACT []
synonym: "positive regulation of abscisic acid biosynthesis" EXACT []
synonym: "positive regulation of abscisic acid formation" EXACT []
synonym: "positive regulation of abscisic acid synthesis" EXACT []
synonym: "stimulation of abscisic acid biosynthetic process" NARROW []
synonym: "up regulation of abscisic acid biosynthetic process" EXACT []
synonym: "up-regulation of abscisic acid biosynthetic process" EXACT []
synonym: "upregulation of abscisic acid biosynthetic process" EXACT []
is_a: GO:0010115 ! regulation of abscisic acid biosynthetic process
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process
is_a: GO:0046889 ! positive regulation of lipid biosynthetic process
is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009688 ! abscisic acid biosynthetic process
relationship: positively_regulates GO:0009688 ! abscisic acid biosynthetic process

[Term]
id: GO:0010117
name: photoprotection
namespace: biological_process
def: "Protection mechanism used by plants under conditions of excess energy absorption as a consequence of the light reactions of photosynthesis." [GOC:mg]
is_a: GO:0009416 ! response to light stimulus

[Term]
id: GO:0010118
name: stomatal movement
namespace: biological_process
def: "The process of opening or closing of stomata, which is directly related to the stomatal conductance (measuring rate of passage of either water vapor or carbon dioxide (CO2) through stomata)." [GOC:sm]
subset: goslim_pir
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0010119
name: regulation of stomatal movement
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of stomatal movement." [GOC:sm]
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010118 ! stomatal movement
relationship: regulates GO:0010118 ! stomatal movement

[Term]
id: GO:0010120
name: camalexin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of camalexin, an indole phytoalexin." [GOC:pz]
synonym: "camalexin anabolism" EXACT []
synonym: "camalexin biosynthesis" EXACT []
synonym: "camalexin formation" EXACT []
synonym: "camalexin synthesis" EXACT []
xref: MetaCyc:CAMALEXIN-SYN
is_a: GO:0009700 ! indole phytoalexin biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:0052317 ! camalexin metabolic process

[Term]
id: GO:0010121
name: arginine catabolic process to proline via ornithine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including proline, via ornithine." [GOC:pz]
subset: gosubset_prok
synonym: "arginine breakdown to proline via ornithine" EXACT []
synonym: "arginine degradation to proline via ornithine" EXACT []
xref: MetaCyc:ARGORNPROST-PWY
is_a: GO:0019493 ! arginine catabolic process to proline

[Term]
id: GO:0010122
name: arginine catabolic process to alanine via ornithine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including alanine, via ornithine." [GOC:pz]
subset: gosubset_prok
synonym: "arginine breakdown to alanine via ornithine" EXACT []
synonym: "arginine degradation to alanine via ornithine" EXACT []
xref: MetaCyc:ARGORNPROST-PWY
is_a: GO:0006522 ! alanine metabolic process
is_a: GO:0006527 ! arginine catabolic process

[Term]
id: GO:0010123
name: acetate catabolic process to butyrate, ethanol, acetone and butanol
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of acetate to form butyrate, ethanol, acetone and butanol." [GOC:pz]
subset: gosubset_prok
synonym: "acetate fermentation to butyrate, ethanol, acetone and butanol" EXACT []
xref: MetaCyc:CENTFERM-PWY
is_a: GO:0006067 ! ethanol metabolic process
is_a: GO:0019605 ! butyrate metabolic process
is_a: GO:0019654 ! acetate fermentation
is_a: GO:0043443 ! acetone metabolic process
is_a: GO:0045733 ! acetate catabolic process
is_a: GO:0071270 ! 1-butanol metabolic process

[Term]
id: GO:0010124
name: phenylacetate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phenylacetate." [GOC:pz]
subset: gosubset_prok
synonym: "phenylacetate breakdown" EXACT []
synonym: "phenylacetate catabolism" EXACT []
synonym: "phenylacetate degradation" EXACT []
xref: MetaCyc:PWY0-321
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process

[Term]
id: GO:0010125
name: mycothiol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of mycothiol, which consists of N-acetyl-L-cysteine linked to a pseudodisaccharide, D-glucosamine and myo-inositol. Mycothiol is produced in actinomycetes like mycobacteria and serves similar functions to glutathione." [GOC:pz]
subset: gosubset_prok
synonym: "mycothiol anabolism" EXACT []
synonym: "mycothiol biosynthesis" EXACT []
synonym: "mycothiol formation" EXACT []
synonym: "mycothiol synthesis" EXACT []
xref: MetaCyc:PWY1G-0
xref: Reactome:REACT_27216 "Mycothiol biosynthesis, Mycobacterium tuberculosis"
is_a: GO:0010126 ! mycothiol metabolic process
is_a: GO:0016138 ! glycoside biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:0051188 ! cofactor biosynthetic process

[Term]
id: GO:0010126
name: mycothiol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mycothiol, which consists of N-acetyl-L-cysteine linked to a pseudodisaccharide, D-glucosamine and myo-inositol. Mycothiol is produced in actinomycetes like mycobacteria and serves similar functions to glutathione." [GOC:pz]
subset: gosubset_prok
synonym: "mycothiol metabolism" EXACT []
xref: Reactome:REACT_27144 "Mycothiol catabolism, Mycobacterium tuberculosis"
xref: Reactome:REACT_27191 "Mycothiol metabolism, Mycobacterium tuberculosis"
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0016137 ! glycoside metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0051186 ! cofactor metabolic process

[Term]
id: GO:0010127
name: mycothiol-dependent detoxification
namespace: biological_process
def: "The chemical reactions using mycothiol to convert an alkylating agent to an S-conjugate of mycothiol. The latter is cleaved to release mercapturic acid which is excreted from the cell." [GOC:pz]
synonym: "mycothiol-dependent detoxification of alkylating agent" NARROW []
xref: MetaCyc:PWY1G-1
xref: MetaCyc:PWY1G-170
xref: Reactome:REACT_27281 "Mycothiol-dependent detoxification, Mycobacterium tuberculosis"
is_a: GO:0098754 ! detoxification
relationship: part_of GO:0009636 ! response to toxic substance

[Term]
id: GO:0010128
name: benzoate catabolic process via CoA ligation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of benzoate, by its ligation to Coenzyme A to form benzoyl-CoA, which is then broken by an aerobic or anaerobic pathway." [GOC:pz]
subset: gosubset_prok
synonym: "anaerobic benzoate breakdown" EXACT []
synonym: "anaerobic benzoate catabolic process" EXACT []
synonym: "anaerobic benzoate catabolism" EXACT []
synonym: "anaerobic benzoate degradation" EXACT []
xref: MetaCyc:PWY-283
is_a: GO:0018875 ! anaerobic benzoate metabolic process
is_a: GO:0043639 ! benzoate catabolic process

[Term]
id: GO:0010129
name: anaerobic cyclohexane-1-carboxylate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cyclohexane-1-carboxylate, a alicyclic acid, in the absence of oxygen." [GOC:pz]
subset: gosubset_prok
synonym: "anaerobic cyclohexane-1-carboxylate breakdown" EXACT []
synonym: "anaerobic cyclohexane-1-carboxylate catabolism" EXACT []
synonym: "anaerobic cyclohexane-1-carboxylate degradation" EXACT []
xref: MetaCyc:PWY-301
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042178 ! xenobiotic catabolic process

[Term]
id: GO:0010130
name: anaerobic ethylbenzene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ethylbenzene, a benzene derivative with an ethyl group attached to the ring, which occurs in the absence of oxygen." [GOC:pz]
subset: gosubset_prok
synonym: "anaerobic ethylbenzene breakdown" EXACT []
synonym: "anaerobic ethylbenzene catabolism" EXACT []
synonym: "anaerobic ethylbenzene degradation" EXACT []
xref: MetaCyc:PWY-481
is_a: GO:0018913 ! anaerobic ethylbenzene metabolic process

[Term]
id: GO:0010131
name: obsolete sucrose catabolic process, using invertase or sucrose synthase
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of sucrose by the enzymatic action of either invertase or sucrose synthase." [GOC:pz]
comment: This term was made obsolete because it describes two different routes of sucrose catabolism, both of which are represented by molecular functions.
subset: gosubset_prok
synonym: "sucrose breakdown, using invertase or sucrose synthase" EXACT []
synonym: "sucrose catabolic process, using invertase or sucrose synthase" EXACT []
synonym: "sucrose catabolism, using invertase or sucrose synthase" EXACT []
synonym: "sucrose degradation, using invertase or sucrose synthase" EXACT []
xref: MetaCyc:PWY-3801
xref: MetaCyc:PWY-621
is_obsolete: true
consider: GO:0004564
consider: GO:0005987
consider: GO:0016157

[Term]
id: GO:0010132
name: dhurrin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dhurrin, a cyanogenic glucoside which functions as a plant defense compound." [GOC:pz]
subset: gosubset_prok
synonym: "dhurrin anabolism" EXACT []
synonym: "dhurrin biosynthesis" EXACT []
synonym: "dhurrin formation" EXACT []
synonym: "dhurrin synthesis" EXACT []
xref: MetaCyc:PWY-861
is_a: GO:0019756 ! cyanogenic glycoside biosynthetic process
is_a: GO:1901806 ! beta-glucoside biosynthetic process

[Term]
id: GO:0010133
name: proline catabolic process to glutamate
namespace: biological_process
alt_id: GO:0019494
def: "The chemical reactions and pathways resulting in the breakdown of proline into other compounds, including glutamate." [GOC:pz]
subset: gosubset_prok
synonym: "proline breakdown to glutamate" EXACT []
synonym: "proline degradation to glutamate" EXACT []
synonym: "proline oxidation" RELATED []
xref: MetaCyc:PROUT-PWY
xref: MetaCyc:PWY-4561
is_a: GO:0006536 ! glutamate metabolic process
is_a: GO:0006562 ! proline catabolic process

[Term]
id: GO:0010134
name: sulfate assimilation via adenylyl sulfate reduction
namespace: biological_process
def: "The pathway by which inorganic sulfate is activated, reduced and incorporated into sulfated compounds, where the activated sulfate, adenylyl-sulfate, is reduced to sulfite by the activity of adenylyl-sulfate reductase." [EC:1.8.99.2]
subset: gosubset_prok
synonym: "sulphate assimilation via adenylyl sulphate reduction" EXACT []
xref: MetaCyc:SULFMETII-PWY
is_a: GO:0000103 ! sulfate assimilation
is_a: GO:0019419 ! sulfate reduction

[Term]
id: GO:0010135
name: ureide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ureide, allantoin and allantoate, which are the organic forms of nitrogen in nitrogen fixing and transporting plants." [GOC:pz]
subset: gosubset_prok
synonym: "ureide metabolism" EXACT []
is_a: GO:0043603 ! cellular amide metabolic process

[Term]
id: GO:0010136
name: ureide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ureide, which is the organic form of nitrogen in nitrogen fixing and transporting plants with the release of ammonium." [GOC:pz]
subset: gosubset_prok
synonym: "ureide breakdown" EXACT []
synonym: "ureide catabolism" EXACT []
synonym: "ureide degradation" EXACT []
xref: MetaCyc:URDEGR-PWY
is_a: GO:0010135 ! ureide metabolic process
is_a: GO:0044270 ! cellular nitrogen compound catabolic process

[Term]
id: GO:0010137
name: ureide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ureide, the organic form of nitrogen in nitrogen fixing and transporting plants, from IMP, which is synthesized de novo during nitrogen fixation by roots." [GOC:pz]
subset: gosubset_prok
synonym: "ureide anabolism" EXACT []
synonym: "ureide biosynthesis" EXACT []
synonym: "ureide formation" EXACT []
synonym: "ureide synthesis" EXACT []
xref: MetaCyc:URSIN-PWY
is_a: GO:0010135 ! ureide metabolic process
is_a: GO:0043604 ! amide biosynthetic process

[Term]
id: GO:0010138
name: pyrimidine ribonucleotide salvage
namespace: biological_process
def: "The pathway by which pyrimidine bases or pyrimidine ribonucleosides from pyrimidine nucleotide breakdown are converted back to pyrimidine ribonucleotides. The salvage pathway is important where there is no de novo pyrimidine nucleotide biosynthesis." [GOC:pz]
subset: gosubset_prok
xref: MetaCyc:PWY0-163
is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process
is_a: GO:0032262 ! pyrimidine nucleotide salvage

[Term]
id: GO:0010139
name: pyrimidine deoxyribonucleotide salvage
namespace: biological_process
def: "The pathway by which pyrimidine bases or pyrimidine deoxyribonucleotides from pyrimidine nucleotide breakdown are converted back to pyrimidine deoxyribonucleotides. The salvage pathway is important where there is no de novo pyrimidine deoxyribonucleotide biosynthesis." [GOC:pz]
subset: gosubset_prok
xref: MetaCyc:PWY0-181
is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process
is_a: GO:0032262 ! pyrimidine nucleotide salvage

[Term]
id: GO:0010140
name: obsolete adenine, hypoxanthine and their nucleoside salvage
namespace: biological_process
def: "OBSOLETE. The pathway by which adenine, hypoxanthine and their nucleosides from purine nucleotides breakdown are converted back to purine nucleotides. The salvage pathway is important where there is no de-novo purine nucleotide biosynthesis." [GOC:pz]
comment: This term was made obsolete because it represents multiple processes that are represented elsewhere in the process ontology.
synonym: "adenine, hypoxanthine and their nucleoside salvage" EXACT []
is_obsolete: true
consider: GO:0006168
consider: GO:0006169
consider: GO:0006190
consider: GO:0043103

[Term]
id: GO:0010141
name: obsolete guanine, xanthine and their nucleoside salvage
namespace: biological_process
def: "OBSOLETE. The pathway by which guanine, xanthine and their nucleoside from purine nucleotides breakdown are converted back to purine nucleotides. The pathway is important in cells where there is no de-novo purine nucleotides biosynthesis." [GOC:pz]
comment: This term was made obsolete because it represents multiple processes that are represented elsewhere in the process ontology.
synonym: "guanine, xanthine and their nucleoside salvage" EXACT []
is_obsolete: true
consider: GO:0006178
consider: GO:0006179
consider: GO:0006190
consider: GO:0043103

[Term]
id: GO:0010142
name: farnesyl diphosphate biosynthetic process, mevalonate pathway
namespace: biological_process
def: "The pathway that converts acetate, in the form of acetyl-CoA, to farnesyl diphosphate (FPP) through a series of mevalonate intermediates. Farnesyl diphosphate is an important substrate for other essential pathways, such as biosynthesis of sterols." [GOC:pz, MetaCyc:PWY-922]
subset: gosubset_prok
synonym: "Ac-MVA pathway" NARROW [PMID:14517367]
synonym: "acetate-mevalonate pathway" NARROW [PMID:14517367]
synonym: "farnesyl diphosphate anabolism, mevalonate pathway" EXACT []
synonym: "farnesyl diphosphate formation, mevalonate pathway" EXACT []
synonym: "farnesyl diphosphate synthesis, mevalonate pathway" EXACT []
synonym: "isoprenoid pathway" EXACT []
xref: MetaCyc:PWY-922
is_a: GO:0045337 ! farnesyl diphosphate biosynthetic process
is_a: GO:1902767 ! isoprenoid biosynthetic process via mevalonate
relationship: part_of GO:0016114 ! terpenoid biosynthetic process

[Term]
id: GO:0010143
name: cutin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cutin, a waxy substance, which combined with cellulose forms a substance nearly impervious to water and constituting the cuticle in plants." [ISBN:0028623819]
synonym: "cutin anabolism" EXACT []
synonym: "cutin biosynthesis" EXACT []
synonym: "cutin formation" EXACT []
synonym: "cutin synthesis" EXACT []
xref: MetaCyc:PWY-321
is_a: GO:0009059 ! macromolecule biosynthetic process

[Term]
id: GO:0010144
name: pyridoxal phosphate biosynthetic process from pyridoxamine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyridoxal phosphate, the active form of vitamin B6, from pyridoxamine." [GOC:pz]
subset: gosubset_prok
synonym: "pyridoxal 5'-phosphate salvage from pyridoxamine" EXACT []
synonym: "pyridoxal phosphate anabolism from pyridoxamine" EXACT []
synonym: "pyridoxal phosphate formation from pyridoxamine" EXACT []
synonym: "pyridoxal phosphate synthesis from pyridoxamine" EXACT []
synonym: "vitamin B6 biosynthesis from pyridoxamine" EXACT []
synonym: "vitamin B6 biosynthetic process from pyridoxamine" EXACT []
is_a: GO:0009443 ! pyridoxal 5'-phosphate salvage
is_a: GO:0042818 ! pyridoxamine metabolic process

[Term]
id: GO:0010145
name: fructan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fructan, a polysaccharide consisting of fructose residues." [GOC:sm]
subset: gosubset_prok
synonym: "fructan metabolism" EXACT []
synonym: "levan metabolic process" EXACT []
is_a: GO:0044264 ! cellular polysaccharide metabolic process

[Term]
id: GO:0010146
name: fructan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of fructan a polysaccharide consisting of fructose residues." [GOC:pz]
subset: gosubset_prok
synonym: "fructan anabolism" EXACT []
synonym: "fructan biosynthesis" EXACT []
synonym: "fructan formation" EXACT []
synonym: "fructan synthesis" EXACT []
synonym: "levan biosynthesis" EXACT []
synonym: "levan biosynthetic process" EXACT []
xref: MetaCyc:PWY-822
is_a: GO:0010145 ! fructan metabolic process
is_a: GO:0033692 ! cellular polysaccharide biosynthetic process

[Term]
id: GO:0010147
name: fructan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of fructan, a polysaccharide consisting of fructose residues." [GOC:pz]
subset: gosubset_prok
synonym: "fructan breakdown" EXACT []
synonym: "fructan catabolism" EXACT []
synonym: "fructan degradation" EXACT []
synonym: "levan catabolic process" EXACT []
synonym: "levan catabolism" EXACT []
xref: MetaCyc:PWY-862
is_a: GO:0010145 ! fructan metabolic process
is_a: GO:0044247 ! cellular polysaccharide catabolic process

[Term]
id: GO:0010148
name: transpiration
namespace: biological_process
def: "Release of water by the plant into the air as water vapor mainly through leaves." [GOC:sm, ISBN:0879015322]
xref: Wikipedia:Transpiration
is_a: GO:0006833 ! water transport

[Term]
id: GO:0010149
name: obsolete senescence
namespace: biological_process
def: "OBSOLETE. A preprogrammed process associated with the dismantling of an anatomical structure and an overall decline in metabolism. This may include the breakdown of organelles, membranes and other cellular components. An example of this process is found in Arabidopsis thaliana, when older leaves or floral organs are shed." [GOC:mtg_sensu, ISBN:0387987819]
comment: This term was made obsolete because its name is ambiguous and it is covered by the two more specific terms: 'organ senescence ; GO:0010260' and 'cell aging ; GO:0007569'.
synonym: "senescence" EXACT []
xref: Wikipedia:Senescence
is_obsolete: true

[Term]
id: GO:0010150
name: leaf senescence
namespace: biological_process
def: "The process that occurs in a leaf near the end of its active life that is associated with the dismantling of cell components and membranes, loss of functional chloroplasts, and an overall decline in metabolism." [ISBN:0387987819]
is_a: GO:0010260 ! organ senescence
relationship: part_of GO:0048366 ! leaf development

[Term]
id: GO:0010151
name: chloroplast elongation
namespace: biological_process
def: "Expansion of the chloroplast that usually precedes division." [GOC:lr]
is_a: GO:0009658 ! chloroplast organization

[Term]
id: GO:0010152
name: pollen maturation
namespace: biological_process
def: "The final stages of microgametogenesis after the trinucleate stage has been reached resulting in viable pollen grains." [PMID:11595796]
is_a: GO:0021700 ! developmental maturation
relationship: part_of GO:0009555 ! pollen development

[Term]
id: GO:0010153
name: obsolete polar cell elongation
namespace: biological_process
def: "OBSOLETE. Cell expansion that results in an increase in cell size along the axis of an organ in a polarized fashion." [PMID:11978864]
comment: This term was made obsolete because it did not represent a process discrete from its sibling terms.
synonym: "polar cell elongation" EXACT []
synonym: "polarity-dependent cell elongation" NARROW []
is_obsolete: true
consider: GO:0042814
consider: GO:0042815

[Term]
id: GO:0010154
name: fruit development
namespace: biological_process
def: "The process whose specific outcome is the progression of the fruit over time, from its formation to the mature structure. The fruit is a reproductive body of a seed plant." [GOC:sm]
is_a: GO:0048608 ! reproductive structure development

[Term]
id: GO:0010155
name: regulation of proton transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of proton transport into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:sm]
is_a: GO:0043269 ! regulation of ion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0015992 ! proton transport
relationship: regulates GO:0015992 ! proton transport

[Term]
id: GO:0010156
name: obsolete sporocyte morphogenesis
namespace: biological_process
def: "OBSOLETE. Formation and development of sporocyte, the haploid spores of angiosperms which are initiated by the differentiation of a subset of floral cells into sporocytes, which then undergo meiotic divisions to form microspores and megaspores." [PMID:10465788]
comment: This term was made obsolete because it was incorrectly defined.
synonym: "sporocyte morphogenesis" EXACT []
is_obsolete: true
consider: GO:0048533

[Term]
id: GO:0010157
name: response to chlorate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chlorate stimulus." [GOC:sm]
is_a: GO:0001101 ! response to acid chemical
is_a: GO:0010035 ! response to inorganic substance
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0010158
name: abaxial cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into an abaxial cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:mg]
is_a: GO:0001708 ! cell fate specification

[Term]
id: GO:0010159
name: specification of organ position
namespace: biological_process
def: "The regionalization process in which information that determines the correct position at which organ primordia are formed is generated and perceived resulting in correct positioning of the new organ." [PMID:9611175]
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0009887 ! organ morphogenesis

[Term]
id: GO:0010160
name: formation of organ boundary
namespace: biological_process
alt_id: GO:0048862
def: "The regionalization process that specifies organ primordium boundaries resulting in a restriction of organogenesis to a limited spatial domain and keeping the organ separate from surrounding tissues." [GOC:dph, GOC:isa_complete, PMID:9611175]
synonym: "organ boundary specification" EXACT []
is_a: GO:0003002 ! regionalization
is_a: GO:0048859 ! formation of anatomical boundary
relationship: part_of GO:0048645 ! organ formation

[Term]
id: GO:0010161
name: red light signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated upon sensing of red light by a photoreceptor molecule. Red light is electromagnetic radiation of wavelength of 580-700nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:mtg_far_red, GOC:sm]
synonym: "red light phototransduction" EXACT [GOC:signaling]
synonym: "red light signal transduction" EXACT [GOC:signaling]
synonym: "red light signalling pathway" EXACT []
is_a: GO:0010017 ! red or far-red light signaling pathway
is_a: GO:0071491 ! cellular response to red light

[Term]
id: GO:0010162
name: seed dormancy process
namespace: biological_process
def: "A dormancy process in which dormancy (sometimes called a dormant state) is induced, maintained or broken in a seed. Seed dormancy is a suspension of most physiological activity and growth in a seed, including the embryo contained therein, that can be reactivated. It often requires special conditions for reactivation, such as specific temperature, scarification, or leaching of inhibitors." [GOC:lr, GOC:PO_curators, ISBN:9781405139830, PO_REF:00009]
synonym: "seed dormancy" RELATED []
xref: Wikipedia:Seed#Seed_dormancy_and_protection
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0022611 ! dormancy process
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0044707 ! single-multicellular organism process
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048609 ! multicellular organismal reproductive process
relationship: part_of GO:0010431 ! seed maturation

[Term]
id: GO:0010163
name: high-affinity potassium ion import
namespace: biological_process
def: "The directed, energized, high affinity movement of potassium ions into a cell or organelle, driven by cation symport with hydrogen or sodium ions. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [PMID:8893537]
synonym: "high affinity potassium ion import" EXACT []
synonym: "high affinity potassium ion uptake" EXACT [GOC:dph, GOC:tb]
synonym: "high-affinity potassium ion uptake" EXACT [GOC:dph, GOC:tb]
is_a: GO:0071805 ! potassium ion transmembrane transport

[Term]
id: GO:0010164
name: response to cesium ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cesium stimulus." [GOC:sm]
synonym: "response to cesium" EXACT [GOC:mah]
is_a: GO:0010038 ! response to metal ion

[Term]
id: GO:0010165
name: response to X-ray
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz)." [GOC:sm, Wikipedia:X-ray]
synonym: "response to X-ray radiation stimulus" EXACT []
is_a: GO:0010212 ! response to ionizing radiation

[Term]
id: GO:0010166
name: wax metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving wax, a compound containing C16 and C18 fatty acids." [GOC:sm]
subset: gosubset_prok
synonym: "wax metabolism" EXACT []
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0010167
name: response to nitrate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrate stimulus." [GOC:sm]
is_a: GO:0001101 ! response to acid chemical
is_a: GO:0010035 ! response to inorganic substance
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0010168
name: ER body
namespace: cellular_component
def: "A novel compartment found in plant cells that is derived from the ER. The structures have a characteristic shape and size (10 mm long and 0.5 mm wide) and are surrounded with ribosomes. They have been found in Arabidopsis thaliana and related Brassicaceae species." [PMID:11577182]
synonym: "endoplasmic reticulum body" EXACT []
is_a: GO:0043231 ! intracellular membrane-bounded organelle

[Term]
id: GO:0010169
name: thioglucosidase complex
namespace: cellular_component
def: "A large (200-800 kDa) multiprotein complex formed by 70-kDa and 5-kDa myrosinases, myrosinase- binding proteins (MBPs), MBP-related proteins and myrosinase-associated proteins. The complex has been identified in Brassica napus seeds." [PMID:10682349]
synonym: "myrosinase complex" EXACT []
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0010170
name: glucose-1-phosphate adenylyltransferase complex
namespace: cellular_component
def: "Complex that catalyzes the synthesis of ADP-glucose and pyrophosphate from glucose-1-phosphate and ATP. In plants, the complex is a heterotetramer composed of two types of subunits (small and large). In bacteria, the enzyme complex is composed of four identical subunits." [GOC:tb, PMID:12748181]
subset: gosubset_prok
is_a: GO:0044424 ! intracellular part
is_a: GO:1902503 ! adenylyltransferase complex

[Term]
id: GO:0010171
name: body morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the soma are generated and organized." [GOC:ems, ISBN:0140512888]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process

[Term]
id: GO:0010172
name: embryonic body morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the embryonic soma are generated and organized." [GOC:ems]
is_a: GO:0010171 ! body morphogenesis
is_a: GO:0048598 ! embryonic morphogenesis

[Term]
id: GO:0010174
name: nucleoside transmembrane transporter activity, against a concentration gradient
namespace: molecular_function
def: "Catalysis of the transfer of a nucleoside, from one side of a membrane to the other, up a concentration gradient." [GOC:tb]
synonym: "concentrative nucleoside transporter activity" EXACT []
is_a: GO:0005337 ! nucleoside transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0010175
name: sphingosine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of amino alcohol sphingosine from one side of the membrane to the other." [GOC:tb]
is_a: GO:0008519 ! ammonium transmembrane transporter activity
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:0015166 ! polyol transmembrane transporter activity
is_a: GO:0046624 ! sphingolipid transporter activity

[Term]
id: GO:0010176
name: homogentisate phytyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: homogentisate + phytyl diphosphate + H+ = 2-methyl-6-phytyl-1,4-benzoquinone + CO2 + diphosphate. 2-methyl-6-phytyl-1,4-benzoquinone is also known as 2-methyl-6-phytylplastoquinol." [MetaCyc:RXN-2541, PMID:14512521]
xref: KEGG:R07500
xref: MetaCyc:RXN-2541
is_a: GO:0010354 ! homogentisate prenyltransferase activity

[Term]
id: GO:0010177
name: 2-(2'-methylthio)ethylmalate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxo-4-methylthiobutanoate + acetyl-CoA + H2O = 2-(2'-methylthio)ethylmalic-acid + coenzyme A + H+." [MetaCyc:RXN-2202]
synonym: "methylthioalkylmalate synthase activity" BROAD [MetaCyc:RXN-2202]
xref: EC:2.3.3.-
xref: MetaCyc:RXN-2202
is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

[Term]
id: GO:0010178
name: IAA-amino acid conjugate hydrolase activity
namespace: molecular_function
def: "Catalysis of the cleavage of the amide bond between IAA (auxin) and the conjugated amino acid." [GOC:tb]
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

[Term]
id: GO:0010179
name: IAA-Ala conjugate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: indole-3-acetyl-alanine + H2O = indole-3-acetate + L-alanine." [MetaCyc:RXN-2981]
xref: MetaCyc:RXN-2981
is_a: GO:0010178 ! IAA-amino acid conjugate hydrolase activity

[Term]
id: GO:0010180
name: thioglucosidase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the enzyme thioglucosidase." [GOC:tb]
synonym: "myrosinase binding" EXACT []
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0010181
name: FMN binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb]
subset: gosubset_prok
synonym: "flavin mononucleotide binding" EXACT []
is_a: GO:0032553 ! ribonucleotide binding
is_a: GO:0048037 ! cofactor binding

[Term]
id: GO:0010182
name: sugar mediated signaling pathway
namespace: biological_process
def: "The process in which a change in the level of a mono- or disaccharide such as glucose, fructose or sucrose triggers the expression of genes controlling metabolic and developmental processes." [PMID:9014361]
synonym: "sugar mediated signalling" EXACT []
is_a: GO:0009756 ! carbohydrate mediated signaling

[Term]
id: GO:0010183
name: pollen tube guidance
namespace: biological_process
def: "The process in which the growth of pollen tube is directed towards the female gametophyte." [GOC:lr]
is_a: GO:0022414 ! reproductive process
is_a: GO:0050918 ! positive chemotaxis
relationship: part_of GO:0048868 ! pollen tube development

[Term]
id: GO:0010184
name: cytokinin transport
namespace: biological_process
def: "The directed movement of cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:lr]
is_a: GO:0009914 ! hormone transport

[Term]
id: GO:0010185
name: regulation of cellular defense response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular defense response." [GOC:sm]
synonym: "regulation of cellular defence response" EXACT []
is_a: GO:0031347 ! regulation of defense response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006968 ! cellular defense response
relationship: regulates GO:0006968 ! cellular defense response

[Term]
id: GO:0010186
name: positive regulation of cellular defense response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellular defense response." [GOC:sm]
synonym: "activation of cellular defense response" NARROW []
synonym: "positive regulation of cellular defence response" EXACT []
synonym: "stimulation of cellular defense response" NARROW []
synonym: "up regulation of cellular defense response" EXACT []
synonym: "up-regulation of cellular defense response" EXACT []
synonym: "upregulation of cellular defense response" EXACT []
is_a: GO:0010185 ! regulation of cellular defense response
is_a: GO:0031349 ! positive regulation of defense response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006968 ! cellular defense response
relationship: positively_regulates GO:0006968 ! cellular defense response

[Term]
id: GO:0010187
name: negative regulation of seed germination
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of seed germination." [GOC:tb]
synonym: "down regulation of seed germination" EXACT []
synonym: "down-regulation of seed germination" EXACT []
synonym: "downregulation of seed germination" EXACT []
synonym: "inhibition of seed germination" NARROW []
is_a: GO:0010029 ! regulation of seed germination
is_a: GO:0048581 ! negative regulation of post-embryonic development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009845 ! seed germination
relationship: negatively_regulates GO:0009845 ! seed germination

[Term]
id: GO:0010188
name: response to microbial phytotoxin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a microbial phytotoxin stimulus. A microbial phytotoxin is a chemical substance produced by microbes which is toxic to plants." [GOC:sm]
is_a: GO:0009636 ! response to toxic substance

[Term]
id: GO:0010189
name: vitamin E biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant." [GOC:mg]
subset: gosubset_prok
synonym: "alpha-tocopherol biosynthesis" NARROW []
synonym: "alpha-tocopherol biosynthetic process" NARROW []
synonym: "tocopherol biosynthesis" EXACT []
synonym: "tocopherol biosynthetic process" EXACT []
synonym: "vitamin E anabolism" EXACT []
synonym: "vitamin E biosynthesis" EXACT []
synonym: "vitamin E formation" EXACT []
synonym: "vitamin E synthesis" EXACT []
xref: MetaCyc:PWY-1422
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0042360 ! vitamin E metabolic process
is_a: GO:0042362 ! fat-soluble vitamin biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process

[Term]
id: GO:0010190
name: cytochrome b6f complex assembly
namespace: biological_process
def: "Formation of cytochrome b6f complex, a complex that transfers electrons from reduced plastoquinone to oxidized plastocyanin and translocates protons from the stroma to the lumen, by the aggregation, arrangement and bonding together of its constituents." [GOC:tb]
subset: gosubset_prok
synonym: "cytochrome b6f complex biogenesis" EXACT []
is_a: GO:0017004 ! cytochrome complex assembly

[Term]
id: GO:0010191
name: mucilage metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mucilage, a gelatinous substance secreted by plants." [GOC:sm]
subset: goslim_pir
synonym: "mucilage metabolism" EXACT []
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0010192
name: mucilage biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of mucilage, a gelatinous substance secreted by plants." [GOC:sm]
synonym: "mucilage anabolism" EXACT []
synonym: "mucilage biosynthesis" EXACT []
synonym: "mucilage formation" EXACT []
synonym: "mucilage synthesis" EXACT []
is_a: GO:0010191 ! mucilage metabolic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0010193
name: response to ozone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ozone stimulus." [GOC:sm]
is_a: GO:0000302 ! response to reactive oxygen species
is_a: GO:0001101 ! response to acid chemical
is_a: GO:0010035 ! response to inorganic substance

[Term]
id: GO:0010194
name: obsolete microRNA metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving microRNA, a large family of 21-22 nucleotide non-coding RNAs with presumed post-transcriptional regulatory activity." [GOC:sm]
comment: This term was made obsolete because it implies further processing of an end product rather than its production.
synonym: "microRNA metabolic process" EXACT []
is_obsolete: true
replaced_by: GO:0035196

[Term]
id: GO:0010195
name: obsolete microRNA biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of microRNA, a large family of 21-22 nucleotide non-coding RNAs with presumed post-transcriptional regulatory activity." [GOC:sm]
comment: This term was made obsolete because it represents a process that is not known to occur.
synonym: "microRNA anabolism" EXACT []
synonym: "microRNA biosynthesis" EXACT []
synonym: "microRNA biosynthetic process" EXACT []
synonym: "microRNA formation" EXACT []
synonym: "microRNA synthesis" EXACT []
synonym: "miRNA biosynthesis" EXACT []
synonym: "miRNA biosynthetic process" EXACT []
is_obsolete: true
replaced_by: GO:0035196

[Term]
id: GO:0010196
name: nonphotochemical quenching
namespace: biological_process
def: "The process by which excess light energy absorbed by chlorophyll and not used to drive photosynthesis is emitted as heat. This process helps maintain the balance between dissipation and utilization of light energy to minimize generation of oxidizing molecules, thereby protecting the plant against photo-oxidative damage." [PMID:10667783, PMID:10938857]
is_a: GO:1990066 ! energy quenching

[Term]
id: GO:0010197
name: polar nucleus fusion
namespace: biological_process
def: "The merging of the polar nuclei, the two nuclei contained within the same cell that are created from the mitotic division of the megaspore during angiosperm reproduction. Polar nuclear fusion takes place in the ovule, forming in the fusion nucleus and giving rise to the endosperm when fertilized." [GOC:mtg_plant, GOC:sm]
is_a: GO:0000741 ! karyogamy
relationship: part_of GO:0009559 ! embryo sac central cell differentiation

[Term]
id: GO:0010198
name: synergid death
namespace: biological_process
alt_id: GO:0048470
def: "Synergid cells undergo degeneration and death in response to penetration by the pollen tube. It is an active process that involves a dramatic decrease in cell volume, collapse of the vacuoles, and complete disintegration of the plasma membrane and most organelles." [GOC:isa_complete, GOC:sm, PMID:12215516]
synonym: "synergid cell death" EXACT []
synonym: "synergid degeneration" EXACT []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0010623 ! developmental programmed cell death
is_a: GO:0044702 ! single organism reproductive process
relationship: part_of GO:0009856 ! pollination

[Term]
id: GO:0010199
name: organ boundary specification between lateral organs and the meristem
namespace: biological_process
def: "The process in which boundaries between lateral organs and the meristem is established and maintained." [PMID:12068116]
is_a: GO:0010160 ! formation of organ boundary

[Term]
id: GO:0010200
name: response to chitin
namespace: biological_process
def: "A process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chitin stimulus." [GOC:sm]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0010201
name: response to continuous far red light stimulus by the high-irradiance response system
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of a continuous far red light stimulus by the high-irradiance response system. Far red light is electromagnetic radiation of wavelength 700-800nm. The activity of the high-irradiance response system is characterized by stronger effects of continuous than pulsed light at equal total fluence." [GOC:mtg_far_red, GOC:sm]
is_a: GO:0010218 ! response to far red light

[Term]
id: GO:0010202
name: response to low fluence red light stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low fluence red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Low fluence red light is defined in this case as short pulses of red light followed by darkness, providing a light level of 0.001-0.1 mmol/m2/sec." [GOC:mtg_far_red, GOC:sm]
is_a: GO:0009645 ! response to low light intensity stimulus
is_a: GO:0010114 ! response to red light

[Term]
id: GO:0010203
name: response to very low fluence red light stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a very low fluence red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Very low fluence red light is defined in this case as short pulses of red light followed by darkness, providing light levels of less than 0.001 mmol/m2/sec." [GOC:mtg_far_red, GOC:sm]
is_a: GO:0010114 ! response to red light
is_a: GO:0055122 ! response to very low light intensity stimulus

[Term]
id: GO:0010204
name: defense response signaling pathway, resistance gene-independent
namespace: biological_process
def: "A series of molecular signals that is activated during defense response and does not depend upon R-genes." [GOC:mah, GOC:sm]
synonym: "defence response signaling pathway, resistance gene-independent" EXACT []
synonym: "defence response signalling pathway, resistance gene-independent" EXACT []
is_a: GO:0002218 ! activation of innate immune response
is_a: GO:0007165 ! signal transduction

[Term]
id: GO:0010205
name: photoinhibition
namespace: biological_process
def: "The mechanism by which high light intensity inhibits photosynthesis through inactivation of the D1 protein of photosystem II." [GOC:mtg_electron_transport, PMID:12068126]
synonym: "photosystem II inhibition" BROAD []
xref: Wikipedia:Photoinhibition
is_a: GO:0009644 ! response to high light intensity
is_a: GO:0043155 ! negative regulation of photosynthesis, light reaction
relationship: negatively_regulates GO:0009767 ! photosynthetic electron transport chain

[Term]
id: GO:0010206
name: photosystem II repair
namespace: biological_process
def: "Proteolysis of the damaged D1 protein and re-assembly of a new D1 subunit in the photosystem II following photoinhibition." [GOC:sm]
is_a: GO:0030091 ! protein repair
relationship: part_of GO:0009765 ! photosynthesis, light harvesting

[Term]
id: GO:0010207
name: photosystem II assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a photosystem II complex on the thylakoid membrane. The photosystem II complex consists of at least 20 polypeptides and around 80 cofactors in most organisms." [GOC:aa, GOC:pz]
is_a: GO:0043623 ! cellular protein complex assembly
relationship: part_of GO:0019684 ! photosynthesis, light reaction

[Term]
id: GO:0010208
name: pollen wall assembly
namespace: biological_process
def: "The formation of reticulate pollen wall pattern consisting of two layers, exine and intine." [PMID:11743117]
synonym: "pollen wall formation" RELATED [GOC:dph, GOC:tb]
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
is_a: GO:0045229 ! external encapsulating structure organization
is_a: GO:0085029 ! extracellular matrix assembly
relationship: part_of GO:0009555 ! pollen development

[Term]
id: GO:0010209
name: vacuolar sorting signal binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a vacuolar sorting signal, a specific peptide sequence that acts as a signal to localize the protein within the vacuole." [GOC:mah]
is_a: GO:0005048 ! signal sequence binding

[Term]
id: GO:0010210
name: IAA-Phe conjugate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: indole-3-acetyl-phenylalanine + H2O = indole-3-acetate + phenylalanine." [GOC:syr]
is_a: GO:0010178 ! IAA-amino acid conjugate hydrolase activity

[Term]
id: GO:0010211
name: IAA-Leu conjugate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: indole-3-acetyl-leucine + H2O = indole-3-acetate + L-leucine." [MetaCyc:RXN-2982]
xref: MetaCyc:RXN-2982
is_a: GO:0010178 ! IAA-amino acid conjugate hydrolase activity

[Term]
id: GO:0010212
name: response to ionizing radiation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays." [PMID:12509526]
synonym: "response to ionising radiation" EXACT []
synonym: "response to ionizing radiation stimulus" EXACT []
is_a: GO:0009314 ! response to radiation

[Term]
id: GO:0010213
name: non-photoreactive DNA repair
namespace: biological_process
def: "A DNA repair process that is involved in repairing UV-induced DNA damage under non-photoreactivating conditions. The mechanism by which this repair process operates has not yet been completely elucidated." [GOC:syr]
subset: gosubset_prok
synonym: "light-independent DNA repair" EXACT [GOC:syr]
is_a: GO:0006281 ! DNA repair

[Term]
id: GO:0010214
name: seed coat development
namespace: biological_process
def: "The process whose specific outcome is the progression of the seed coat over time, from its formation to the mature structure." [GOC:go_curators]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048316 ! seed development

[Term]
id: GO:0010215
name: cellulose microfibril organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cellulose microfibril, any of the cellulose structures laid down in orthogonal layers in a plant cell wall." [GOC:mah, PMID:12468730]
synonym: "cellulose microfibril organisation" EXACT [GOC:curators]
is_a: GO:0030198 ! extracellular matrix organization
relationship: part_of GO:0071668 ! plant-type cell wall assembly

[Term]
id: GO:0010216
name: maintenance of DNA methylation
namespace: biological_process
def: "Any process involved in maintaining the methylation state of a nucleotide sequence." [PMID:11898023]
is_a: GO:0006259 ! DNA metabolic process
relationship: has_part GO:0006306 ! DNA methylation

[Term]
id: GO:0010217
name: cellular aluminum ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of aluminum ions at the level of a cell." [GOC:lr, GOC:mah]
synonym: "cellular aluminium ion homeostasis" EXACT [GOC:mah]
is_a: GO:0006875 ! cellular metal ion homeostasis
is_a: GO:0055079 ! aluminum ion homeostasis

[Term]
id: GO:0010218
name: response to far red light
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of far red light stimulus. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:mtg_far_red, GOC:tb]
synonym: "response to far red light stimulus" EXACT []
is_a: GO:0009639 ! response to red or far red light

[Term]
id: GO:0010219
name: regulation of vernalization response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the vernalization response, by which induction of flowering is normally caused by extended exposure to cold temperatures." [GOC:sm]
is_a: GO:0080134 ! regulation of response to stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010048 ! vernalization response
relationship: regulates GO:0010048 ! vernalization response

[Term]
id: GO:0010220
name: positive regulation of vernalization response
namespace: biological_process
def: "Any process that activates or induces the rate of the vernalization response, by which induction of flowering is normally caused by extended exposure to cold temperatures." [GOC:sm]
synonym: "activation of vernalization response" NARROW []
synonym: "stimulation of vernalization response" NARROW []
synonym: "up regulation of vernalization response" EXACT []
synonym: "up-regulation of vernalization response" EXACT []
synonym: "upregulation of vernalization response" EXACT []
is_a: GO:0010219 ! regulation of vernalization response
is_a: GO:0048584 ! positive regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010048 ! vernalization response
relationship: positively_regulates GO:0010048 ! vernalization response

[Term]
id: GO:0010221
name: negative regulation of vernalization response
namespace: biological_process
def: "Any process that stops, prevents or reduces the vernalization response, by which induction of flowering is normally caused by extended exposure to cold temperatures." [GOC:sm]
synonym: "down regulation of vernalization response" EXACT []
synonym: "down-regulation of vernalization response" EXACT []
synonym: "downregulation of vernalization response" EXACT []
synonym: "inhibition of vernalization response" NARROW []
is_a: GO:0010219 ! regulation of vernalization response
is_a: GO:0048585 ! negative regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010048 ! vernalization response
relationship: negatively_regulates GO:0010048 ! vernalization response

[Term]
id: GO:0010222
name: stem vascular tissue pattern formation
namespace: biological_process
def: "Vascular tissue pattern formation as it occurs in the stem of vascular plants." [GOC:tb]
is_a: GO:0010051 ! xylem and phloem pattern formation

[Term]
id: GO:0010223
name: secondary shoot formation
namespace: biological_process
def: "The process that gives rise to secondary (or auxiliary or axillary) shoots in plants. This process pertains to the initial formation of a structure from unspecified parts. These secondary shoots originate from secondary meristems initiated in the axils of leaf primordia. Axillary meristems function like the shoot apical meristem of the primary shoot initating the development of lateral organs." [GOC:tb, PMID:12815068]
synonym: "auxiliary shoot formation" RELATED []
synonym: "axillary shoot formation" RELATED []
synonym: "axillary shoot system formation" EXACT []
synonym: "shoot branching" RELATED []
is_a: GO:0001763 ! morphogenesis of a branching structure
is_a: GO:0010346 ! shoot axis formation

[Term]
id: GO:0010224
name: response to UV-B
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 280 to 315 nm." [GOC:tb]
synonym: "response to medium wave ultraviolet light stimulus" EXACT []
synonym: "response to medium wave ultraviolet radiation stimulus" EXACT []
synonym: "response to UV-B light stimulus" EXACT []
synonym: "response to UV-B radiation stimulus" EXACT []
synonym: "response to UVB light stimulus" EXACT []
synonym: "response to UVB radiation stimulus" EXACT []
is_a: GO:0009411 ! response to UV

[Term]
id: GO:0010225
name: response to UV-C
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-C radiation stimulus. UV-C radiation (UV-C light) spans the wavelengths 100 to 280 nm." [GOC:tb]
synonym: "response to germicidal ultraviolet light stimulus" EXACT []
synonym: "response to germicidal ultraviolet radiation stimulus" EXACT []
synonym: "response to shortwave ultraviolet light stimulus" EXACT []
synonym: "response to shortwave ultraviolet radiation stimulus" EXACT []
synonym: "response to UV-C light stimulus" EXACT []
synonym: "response to UV-C radiation stimulus" EXACT []
synonym: "response to UVC light stimulus" EXACT []
synonym: "response to UVC radiation stimulus" EXACT []
is_a: GO:0009411 ! response to UV

[Term]
id: GO:0010226
name: response to lithium ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus." [GOC:tb]
is_a: GO:0010038 ! response to metal ion

[Term]
id: GO:0010227
name: floral organ abscission
namespace: biological_process
def: "The controlled shedding of floral organs." [GOC:PO_curators, PMID:12972671, PO:0025395]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0009838 ! abscission
relationship: part_of GO:0048437 ! floral organ development

[Term]
id: GO:0010228
name: vegetative to reproductive phase transition of meristem
namespace: biological_process
def: "The process involved in transforming a meristem that produces vegetative structures, such as leaves, into a meristem that produces reproductive structures, such as a flower or an inflorescence." [GOC:tb]
synonym: "floral evocation" RELATED [DOI:10.1146/annurev.pp.39.060188.001135]
synonym: "flowering" RELATED []
synonym: "transition from vegetative to reproductive phase" EXACT []
is_a: GO:0003006 ! developmental process involved in reproduction
relationship: part_of GO:0009791 ! post-embryonic development
relationship: part_of GO:0048608 ! reproductive structure development

[Term]
id: GO:0010229
name: inflorescence development
namespace: biological_process
def: "The process whose specific outcome is the progression of an inflorescence over time, from its formation to the mature structure." [GOC:tb]
is_a: GO:0090567 ! reproductive shoot system development

[Term]
id: GO:0010230
name: alternative respiration
namespace: biological_process
def: "Alternative respiration pathway consumes oxygen, oxidizes NADH to NAD+ and generates water. During electron flow, proton motive force is diminished resulting in fewer molecules of ATP compared to cytochrome pathway. The pathway is found in plants, algae and some protozoa." [ISBN:0943088399]
is_a: GO:0009060 ! aerobic respiration

[Term]
id: GO:0010231
name: maintenance of seed dormancy
namespace: biological_process
def: "Any process that maintains a seed in a dormant state." [ISBN:9781405139830, PMID:9580097]
is_a: GO:0010162 ! seed dormancy process
is_a: GO:0097437 ! maintenance of dormancy

[Term]
id: GO:0010232
name: vascular transport
namespace: biological_process
def: "The directed movement of substances, into, out of or within a cell, either in a vascular tissue or in the vascular membrane." [GOC:sm]
is_a: GO:0044707 ! single-multicellular organism process
is_a: GO:0044765 ! single-organism transport

[Term]
id: GO:0010233
name: phloem transport
namespace: biological_process
def: "The directed movement of substances, into, out of or within a cell, either in a phloem tissue or in the phloem membrane." [GOC:sm]
is_a: GO:0010232 ! vascular transport

[Term]
id: GO:0010234
name: anther wall tapetum cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a tapetal cell of anthers in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:mg]
synonym: "tapetal cell fate specification" BROAD [GOC:tb]
is_a: GO:0001708 ! cell fate specification
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
relationship: part_of GO:0048657 ! anther wall tapetum cell differentiation

[Term]
id: GO:0010235
name: guard mother cell cytokinesis
namespace: biological_process
def: "The stereotyped symmetric cell division by which guard mother cell give rise to stomatal guard cells." [GOC:tb]
synonym: "guard mother cell division" EXACT []
is_a: GO:0000911 ! cytokinesis by cell plate formation
relationship: part_of GO:0010440 ! stomatal lineage progression

[Term]
id: GO:0010236
name: plastoquinone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of plastoquinone, a lipid-soluble electron-transporting coenzyme present in the chloroplast." [GOC:sm]
synonym: "plastoquinone anabolism" EXACT []
synonym: "plastoquinone biosynthesis" EXACT []
synonym: "plastoquinone formation" EXACT []
synonym: "plastoquinone synthesis" EXACT []
xref: MetaCyc:PWY-1581
is_a: GO:1901663 ! quinone biosynthetic process

[Term]
id: GO:0010238
name: response to proline
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a proline stimulus." [GOC:sm]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0043200 ! response to amino acid

[Term]
id: GO:0010239
name: chloroplast mRNA processing
namespace: biological_process
def: "Steps involved in processing precursor RNAs arising from transcription of operons in the chloroplast genome into mature mRNAs." [GOC:tb, PMID:9648738]
is_a: GO:0006397 ! mRNA processing
is_a: GO:0031425 ! chloroplast RNA processing
intersection_of: GO:0006397 ! mRNA processing
intersection_of: occurs_in GO:0009507 ! chloroplast
relationship: occurs_in GO:0009507 ! chloroplast

[Term]
id: GO:0010240
name: plastid pyruvate dehydrogenase complex
namespace: cellular_component
def: "Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). This complex is found in plant plastids and is distinct from the one found in mitochondria." [GOC:mtg_sensu, PMID:9393637]
synonym: "dehydrogenase complex" BROAD []
is_a: GO:0044435 ! plastid part
is_a: GO:0045254 ! pyruvate dehydrogenase complex
intersection_of: GO:0045254 ! pyruvate dehydrogenase complex
intersection_of: part_of GO:0009536 ! plastid
relationship: part_of GO:0009536 ! plastid

[Term]
id: GO:0010241
name: ent-kaurene oxidation to kaurenoic acid
namespace: biological_process
def: "The three successive oxidations of the 4-methyl group of ent-kaurene to form ent-kaur-16-en-19-oate, kaurenoic acid. This process may be carried out entirely by the enzyme ent-kaurene oxidase." [EC:1.14.13.78, GOC:tb]
comment: Note that this term was in molecular function but was moved to biological process as it represents three successive reactions.
synonym: "ent-kaurene oxidation to ent-kaur-16-en-19-oate" EXACT []
synonym: "ent-kaurene oxidation to ent-kaurenoate" EXACT []
synonym: "ent-kaurene oxidation to kaurenoic acid by ent-kaurene oxidase" EXACT []
xref: EC:1.14.13.78
is_a: GO:0033331 ! ent-kaurene metabolic process
is_a: GO:0055114 ! oxidation-reduction process
relationship: has_part GO:0052615 ! ent-kaurene oxidase activity
relationship: has_part GO:0052616 ! ent-kaur-16-en-19-ol oxidase activity
relationship: has_part GO:0052617 ! ent-kaur-16-en-19-al oxidase activity

[Term]
id: GO:0010242
name: oxygen evolving activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 H2O = O2 + 4 H+ + 4 e-. The evolution of oxygen from oxidizing water is carried out by the oxygen evolving complex in photosystem II of plants. P680+, the photochemically oxidized reaction-center chlorophyll of PSII, is a strong biological oxidant. The reduction potential of P680+ is more positive than that of water, and thus it can oxidize water to give O2 and H+ ions. The oxygen escapes as a gas while the H+ ions remain in solution inside the thylakoid vesicle." [GOC:kd, GOC:syr, PMID:17091926, PMID:7948862]
synonym: "photosynthetic water oxidation" EXACT []
xref: MetaCyc:PSII-RXN
xref: MetaCyc:RXN0-5265
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0010243
name: response to organonitrogen compound
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond." [CHEBI:35352, PMID:9869419]
synonym: "response to organic nitrogen" EXACT []
is_a: GO:0009719 ! response to endogenous stimulus
is_a: GO:0010033 ! response to organic substance
is_a: GO:1901698 ! response to nitrogen compound

[Term]
id: GO:0010244
name: response to low fluence blue light stimulus by blue low-fluence system
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of a low fluence blue light stimulus by the blue low-fluence system. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm. The blue low-fluence system responds to blue light at or below 0.1 micromols/m2. In certain species excitation of the blue low fluence system induces the transcription of a number of nuclear and plastid coded genes." [GOC:mtg_far_red, PMID:10398709]
synonym: "response to low fluence blue light" BROAD []
synonym: "response to low fluence blue light by blf system" EXACT []
is_a: GO:0009637 ! response to blue light
is_a: GO:0009645 ! response to low light intensity stimulus

[Term]
id: GO:0010245
name: radial microtubular system formation
namespace: biological_process
def: "Formation of radial microtubular systems during male meiotic cytokinesis in plants." [GOC:syr]
is_a: GO:0000226 ! microtubule cytoskeleton organization

[Term]
id: GO:0010246
name: rhamnogalacturonan I biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of rhamnogalacturonan I component of pectin, a rhamnose-rich pectic polysaccharide." [GOC:pz]
synonym: "rhamnogalacturonan I anabolism" EXACT []
synonym: "rhamnogalacturonan I biosynthesis" EXACT []
synonym: "rhamnogalacturonan I formation" EXACT []
synonym: "rhamnogalacturonan I synthesis" EXACT []
is_a: GO:0000271 ! polysaccharide biosynthetic process
is_a: GO:0010395 ! rhamnogalacturonan I metabolic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0010247
name: detection of phosphate ion
namespace: biological_process
def: "The series of events in which a phosphate ion stimulus is received by a cell and converted into a molecular signal." [GOC:sm]
synonym: "phosphate ion detection" EXACT []
synonym: "phosphate ion perception" RELATED []
synonym: "phosphate ion sensing" RELATED []
is_a: GO:0009593 ! detection of chemical stimulus

[Term]
id: GO:0010248
name: establishment or maintenance of transmembrane electrochemical gradient
namespace: biological_process
def: "The directed movement of ions to establish or maintain an electrochemical gradient across a membrane by means of some agent such as a transporter or pore." [GOC:mah, GOC:sm]
is_a: GO:0034220 ! ion transmembrane transport

[Term]
id: GO:0010249
name: auxin conjugate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving auxin conjugates, a bound form of auxin." [GOC:sm]
synonym: "auxin conjugate metabolism" EXACT []
is_a: GO:0009850 ! auxin metabolic process

[Term]
id: GO:0010250
name: S-methylmethionine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of S-methyl-methionine (SMM) from methionine and S-adenosyl-methionine (Ado-Met), catalyzed by methionine S-methyltransferase (MMT). SMM can be reconverted to methionine by donating a methyl group to homocysteine, and concurrent operation of this reaction and that mediated by MMT sets up the SMM cycle." [PMID:12692340]
synonym: "S-methylmethionine anabolism" EXACT []
synonym: "S-methylmethionine biosynthesis" EXACT []
synonym: "S-methylmethionine formation" EXACT []
synonym: "S-methylmethionine synthesis" EXACT []
is_a: GO:0033477 ! S-methylmethionine metabolic process
is_a: GO:0042398 ! cellular modified amino acid biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process

[Term]
id: GO:0010252
name: auxin homeostasis
namespace: biological_process
def: "A homeostatic process that maintains an endogenous steady-state concentration of primary auxin, or constant level of auxin in a biological system, by a number of biochemical processes including transport, biosynthesis, catabolism and conjugation." [http://diss-epsilon.slu.se/archive/00000215/]
is_a: GO:0048878 ! chemical homeostasis

[Term]
id: GO:0010253
name: UDP-rhamnose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of UDP-L-rhamnose, a substance composed of rhamnose in glycosidic linkage with uridine diphosphate." [PMID:15134748]
synonym: "UDP-rhamnose anabolism" EXACT []
synonym: "UDP-rhamnose biosynthesis" EXACT []
synonym: "UDP-rhamnose formation" EXACT []
synonym: "UDP-rhamnose synthesis" EXACT []
xref: MetaCyc:PWY-3261
is_a: GO:0009226 ! nucleotide-sugar biosynthetic process
is_a: GO:0033478 ! UDP-rhamnose metabolic process

[Term]
id: GO:0010254
name: nectary development
namespace: biological_process
def: "The process whose specific outcome is the progression of the floral nectaries over time, from its formation to the mature structure." [GOC:lr]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0009908 ! flower development

[Term]
id: GO:0010255
name: glucose mediated signaling pathway
namespace: biological_process
def: "The process in which a change in the level of mono- and disaccharide glucose trigger the expression of genes controlling metabolic and developmental processes." [GOC:sm]
synonym: "glucose mediated signalling" EXACT []
is_a: GO:0009757 ! hexose mediated signaling
relationship: part_of GO:0071333 ! cellular response to glucose stimulus

[Term]
id: GO:0010256
name: endomembrane system organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system." [GOC:mah, GOC:sm]
synonym: "endomembrane organization" EXACT [GOC:curators]
synonym: "endomembrane system organisation" EXACT [GOC:mah]
is_a: GO:0016043 ! cellular component organization

[Term]
id: GO:0010257
name: NADH dehydrogenase complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an NADH dehydrogenase complex." [GOC:sm]
is_a: GO:0043623 ! cellular protein complex assembly

[Term]
id: GO:0010258
name: NADH dehydrogenase complex (plastoquinone) assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form NADH:plastoquinone dehydrogenase complex, which is involved in the non-photochemical reduction of plastoquinones, as well as the cyclic electron transport around photosystem I." [PMID:15608332]
is_a: GO:0010257 ! NADH dehydrogenase complex assembly

[Term]
id: GO:0010259
name: multicellular organism aging
namespace: biological_process
def: "An aging process that has as participant a whole multicellular organism. Multicellular organism aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Multicellular organisms aging includes processes like cellular senescence and organ senescence, but is more inclusive. May precede death (GO:0016265) of an organism and may succeed developmental maturation (GO:0021700)." [GOC:PO_curators]
is_a: GO:0007275 ! multicellular organism development
is_a: GO:0007568 ! aging

[Term]
id: GO:0010260
name: organ senescence
namespace: biological_process
alt_id: GO:0010261
def: "The process that occurs in an organ near the end of its active life that is associated with the dismantling of cell components and membranes, and an overall decline in metabolism. An example of this process is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:sm]
is_a: GO:0007568 ! aging
relationship: part_of GO:0048513 ! animal organ development

[Term]
id: GO:0010262
name: somatic embryogenesis
namespace: biological_process
def: "Initiation of a somatic embryo-an embryo arising from previously differentiated somatic cells, rather than from fused haploid gametes." [GOC:sm, PMID:9611173]
is_a: GO:0009793 ! embryo development ending in seed dormancy

[Term]
id: GO:0010263
name: tricyclic triterpenoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tricyclic triterpenoid compounds, terpenoids with 6 isoprene units and 3 carbon rings." [GOC:ct]
synonym: "tricyclic triterpenoid anabolism" EXACT [GOC:tair_curators]
synonym: "tricyclic triterpenoid biosynthesis" EXACT [GOC:tair_curators]
synonym: "tricyclic triterpenoid formation" EXACT [GOC:tair_curators]
synonym: "tricyclic triterpenoid synthesis" EXACT [GOC:tair_curators]
is_a: GO:0010683 ! tricyclic triterpenoid metabolic process
is_a: GO:0016104 ! triterpenoid biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process

[Term]
id: GO:0010264
name: myo-inositol hexakisphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phytic acid, myo-inositol hexakisphosphate, a regulator of intracellular signaling, a highly abundant animal anti-nutrient and a phosphate and mineral storage compound in plant seeds." [CHEBI:17401, PMID:16107538]
synonym: "myo-inositol hexakisphosphate anabolism" EXACT []
synonym: "myo-inositol hexakisphosphate biosynthesis" EXACT []
synonym: "myo-inositol hexakisphosphate formation" EXACT []
synonym: "myo-inositol hexakisphosphate synthesis" EXACT []
synonym: "phytate biosynthesis" EXACT []
synonym: "phytate biosynthetic process" EXACT []
is_a: GO:0032958 ! inositol phosphate biosynthetic process
is_a: GO:0033517 ! myo-inositol hexakisphosphate metabolic process

[Term]
id: GO:0010265
name: SCF complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the SKP1-Cullin/Cdc53-F-box protein ubiquitin ligase (SCF) complex." [GOC:pz]
is_a: GO:0043623 ! cellular protein complex assembly

[Term]
id: GO:0010266
name: response to vitamin B1
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B1 stimulus." [GOC:pz]
synonym: "response to thiamin" EXACT []
synonym: "response to thiamine" EXACT []
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033273 ! response to vitamin

[Term]
id: GO:0010267
name: production of ta-siRNAs involved in RNA interference
namespace: biological_process
def: "Cleavage of double-stranded RNA to form trans-acting small interfering RNA molecules (siRNAs) of 21-23 nucleotides. ta-siRNAs arise from PolII genes and function like miRNAs to guide cleavage of target mRNAs." [GOC:tb, PMID:16129836]
synonym: "RNA interference, production of ta-siRNAs" EXACT [GOC:mah]
is_a: GO:0030422 ! production of siRNA involved in RNA interference

[Term]
id: GO:0010268
name: brassinosteroid homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of brassinosteroids within an organism or cell." [PMID:15908602]
is_a: GO:0055088 ! lipid homeostasis

[Term]
id: GO:0010269
name: response to selenium ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from selenium ion." [GOC:mg]
is_a: GO:0010035 ! response to inorganic substance

[Term]
id: GO:0010270
name: photosystem II oxygen evolving complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the oxygen evolving complex (OEC) of photosystem II on a thylakoid membrane. The OEC protects the calcium-4 manganese-5 oxide cluster which is bound to the D1 and CP43 proteins. The exact protein composition of the OEC varies between cyanobacteria and plants, and in plants consists of three extrinsic nuclear-encoded polypeptides: PsbO, PsbP and PsbQ." [GOC:aa, PMID:16282331]
synonym: "OEC (PSII) ASSEMBLY" EXACT [PMID:16282331]
is_a: GO:0010207 ! photosystem II assembly

[Term]
id: GO:0010271
name: regulation of chlorophyll catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of chlorophyll." [PMID:16361392]
is_a: GO:0090056 ! regulation of chlorophyll metabolic process
is_a: GO:1901404 ! regulation of tetrapyrrole catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0015996 ! chlorophyll catabolic process
relationship: regulates GO:0015996 ! chlorophyll catabolic process

[Term]
id: GO:0010272
name: response to silver ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a silver ion stimulus." [PMID:16367966]
is_a: GO:0010038 ! response to metal ion
is_a: GO:1990267 ! response to transition metal nanoparticle

[Term]
id: GO:0010273
name: detoxification of copper ion
namespace: biological_process
def: "Any process that reduces or removes the toxicity of copper ion. These include transport of copper away from sensitive areas and to compartments or complexes whose purpose is sequestration of copper ion." [GOC:kmv, PMID:16367966]
is_a: GO:0061687 ! detoxification of inorganic compound
relationship: part_of GO:1990169 ! stress response to copper ion

[Term]
id: GO:0010274
name: hydrotropism
namespace: biological_process
def: "Growth or movement in a sessile organism toward or away from water, as of the roots of a plant." [ISBN:0395825172]
xref: Wikipedia:Hydrotropism
is_a: GO:0009606 ! tropism

[Term]
id: GO:0010275
name: NAD(P)H dehydrogenase complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form NAD(P)H dehydrogenase complex, which is involved in electron transport from an unidentified electron donor, possibly NAD(P)H or ferredoxin(Fd) to the plastoquinone pool." [GOC:sm]
synonym: "NAD(P)H dehydrogenase complex (plastoquinone) assembly" NARROW []
is_a: GO:0043623 ! cellular protein complex assembly

[Term]
id: GO:0010276
name: phytol kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: phytol + CTP = phytyl monophosphate + CDP + H+." [MetaCyc:RXN-7683]
xref: EC:2.7.1.-
xref: MetaCyc:RXN-7683
is_a: GO:0016301 ! kinase activity

[Term]
id: GO:0010277
name: chlorophyllide a oxygenase [overall] activity
namespace: molecular_function
alt_id: GO:0046407
def: "Catalysis of the reactions: chlorophyllide a + O2 + NADPH + H+ = 7-hydroxychlorophyllide a + H2O + NADP+; and 7-hydroxychlorophyllide a + O2 + NADPH + H+ = chlorophyllide b + 2 H2O + NADP+." [EC:1.13.12.14, MetaCyc:RXN-7677]
comment: This is a process composed of two reactions represented by the terms 'GO:0052606 : chlorophyllide a oxygenase activity' and 'GO:0052607 : 7-hydroxy-chlorophyllide a oxygenase activity'.
synonym: "CAO activity" BROAD [EC:1.13.12.14]
synonym: "chlorophyll a oxygenation activity" EXACT []
synonym: "chlorophyll b synthesis activity" EXACT []
synonym: "chlorophyll-b synthesis activity" EXACT [EC:1.13.12.14]
synonym: "chlorophyllide a:oxygen 7-oxidoreduction activity" EXACT [EC:1.13.12.14]
synonym: "chlorophyllide-a oxygenation activity" EXACT [EC:1.13.12.14]
xref: EC:1.14.13.122
xref: RHEA:30362 "2 H(+) + 2 NADPH + 2 O(2) + chlorophyllide a = 2 NADP(+) + 3 H(2)O + chlorophyllide b"
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)

[Term]
id: GO:0010278
name: chloroplast outer membrane translocon
namespace: cellular_component
def: "The protein transport machinery of the chloroplast outer membrane that contains at least three components Toc159, Toc75 and Toc34, interacts with precursor proteins which are imported into the chloroplast in a GTP dependant manner." [PMID:11299338]
is_a: GO:0044434 ! chloroplast part
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0009707 ! chloroplast outer membrane

[Term]
id: GO:0010279
name: indole-3-acetic acid amido synthetase activity
namespace: molecular_function
def: "Catalysis of the reaction: indole-3-acetic acid + an amino acid = an indole-3-acetic acid amide conjugate." [PMID:15659623]
synonym: "IAA amido synthetase activity" EXACT []
synonym: "IAA amino acid conjugate synthetase activity" EXACT [GOC:kad]
synonym: "IAA amino acid synthetase activity" EXACT [GOC:kad]
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0010280
name: UDP-L-rhamnose synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-D-glucose + NADPH + H+ = UDP-L-rhamnose + NADP+ + H2O." [MetaCyc:RXN-5482, PMID:14701918]
synonym: "UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase-4-reductase activity" NARROW [GOC:tb]
xref: MetaCyc:RXN-5482
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0010282
name: senescence-associated vacuole
namespace: cellular_component
def: "A lytic vacuole that is maintained at acidic pH and has different tonoplast composition compared to the central vacuole. Found during leaf senescence and develops in the peripheral cytoplasm of cells that contain chloroplast." [PMID:15743448]
synonym: "senescence associated vacuole" EXACT [GOC:curators]
is_a: GO:0000323 ! lytic vacuole
is_a: GO:0000325 ! plant-type vacuole

[Term]
id: GO:0010283
name: pinoresinol reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: pinoresinol + NADPH + H+ = lariciresinol + NADP+." [PMID:10066819, PMID:7592828]
xref: MetaCyc:RXN-8678
xref: MetaCyc:RXN-8683
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0010284
name: lariciresinol reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: lariciresinol + NADPH + H+ = secoisolariciresinol + NADP+." [PMID:10066819, PMID:7592828]
xref: MetaCyc:RXN-8679
xref: MetaCyc:RXN-8684
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0010285
name: L,L-diaminopimelate aminotransferase activity
namespace: molecular_function
alt_id: GO:0043742
def: "Catalysis of the reaction: 2-oxoglutarate + LL-2,6-diaminopimelate = (S)-2,3,4,5-tetrahydrodipicolinate + L-glutamate + H(2)O + H(+)." [EC:2.6.1.83, RHEA:23991]
synonym: "LL-2,6-diaminoheptanedioate:2-oxoglutarate aminotransferase activity" EXACT []
synonym: "LL-DAP aminotransferase activity" EXACT [EC:2.6.1.83]
synonym: "LL-DAP-AT activity" EXACT [EC:2.6.1.83]
synonym: "LL-diaminopimelate aminotransferase activity" EXACT []
synonym: "LL-diaminopimelate transaminase activity" EXACT [EC:2.6.1.83]
xref: EC:2.6.1.83
xref: KEGG:R07613
xref: MetaCyc:RXN-7737
xref: RHEA:23991
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0010286
name: heat acclimation
namespace: biological_process
def: "Any process that increases heat tolerance of an organism in response to high temperatures." [GOC:tair_curators]
synonym: "thermotolerance" RELATED [GOC:tb]
is_a: GO:0009408 ! response to heat

[Term]
id: GO:0010287
name: plastoglobule
namespace: cellular_component
alt_id: GO:0010502
def: "A lipoprotein particle present in chloroplasts. They are rich in non-polar lipids (triglycerides, esters) as well as in prenylquinones, plastoquinone and tocopherols. Plastoglobules are often associated with thylakoid membranes, suggesting an exchange of lipids with thylakoids." [GOC:tair_curators, PMID:16461379]
synonym: "PG" EXACT []
synonym: "plastoglobuli" EXACT []
is_a: GO:0044434 ! chloroplast part
relationship: part_of GO:0009570 ! chloroplast stroma

[Term]
id: GO:0010288
name: response to lead ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus." [GOC:tair_curators, PMID:16461380]
is_a: GO:0010038 ! response to metal ion

[Term]
id: GO:0010289
name: homogalacturonan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the pectidic homogalacturonan, characterized by a backbone of (1->4)-linked alpha-D-GalpA residues that can be methyl-esterified at C-6 and carry acetyl groups on O-2 and O-3." [PMID:12913136, PMID:16540543]
xref: MetaCyc:PWY-1061
is_a: GO:0010394 ! homogalacturonan metabolic process
is_a: GO:0052325 ! cell wall pectin biosynthetic process

[Term]
id: GO:0010290
name: chlorophyll catabolite transmembrane transporter activity
namespace: molecular_function
def: "Enables the directed movement of chlorophyll catabolites such as non-fluorescent chlorophyll catabolites (NCCs), from one side of the membrane to the other." [PMID:9681016]
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity

[Term]
id: GO:0010291
name: carotene beta-ring hydroxylase activity
namespace: molecular_function
alt_id: GO:0042411
def: "Catalysis of the reaction: a carotene + a reduced electron acceptor + O2 = C3-hydroxylated carotene + an oxidized electron acceptor + H2O. This is a general reaction to represent the C3 hydroxylation of the beta ring of a carotene." [MetaCyc:MONOMER-12386, PMID:16492736]
synonym: "beta-carotene hydroxylase activity" NARROW []
is_a: GO:0004497 ! monooxygenase activity

[Term]
id: GO:0010292
name: GTP:GDP antiporter activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP(out) + GDP(in) = GTP(in) + GDP(out)." [PMID:10514379, PMID:12553910, PMID:16553903]
is_a: GO:0001409 ! guanine nucleotide transmembrane transporter activity
is_a: GO:0005346 ! purine ribonucleotide transmembrane transporter activity
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015211 ! purine nucleoside transmembrane transporter activity
is_a: GO:0015301 ! anion:anion antiporter activity

[Term]
id: GO:0010293
name: abscisic aldehyde oxidase activity
namespace: molecular_function
alt_id: GO:0033725
def: "Catalysis of the reaction: (+)-abscisic aldehyde + H(2)O + O(2) = abscisate + H(2)O(2) + H(+)." [EC:1.2.3.14, RHEA:20532]
synonym: "AAO3" RELATED [EC:1.2.3.14]
synonym: "abscisic-aldehyde oxidase activity" EXACT [EC:1.2.3.14]
synonym: "abscisic-aldehyde:oxygen oxidoreductase activity" EXACT [EC:1.2.3.14]
synonym: "AOdelta" RELATED [EC:1.2.3.14]
xref: EC:1.2.3.14
xref: KEGG:R06957
xref: MetaCyc:1.2.3.14-RXN
xref: RHEA:20532
is_a: GO:0018488 ! aryl-aldehyde oxidase activity

[Term]
id: GO:0010294
name: abscisic acid glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (+)-abscisate + UDP-D-glucose = abscisic acid glucose ester + UDP." [DOI:10.1016/j.tetasy.2004.11.062]
xref: MetaCyc:RXN-8155
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0010295
name: (+)-abscisic acid 8'-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: (+)-abscisate + H(+) + NADPH + O(2) = (+)-8'-hydroxyabscisate + H(2)O + NADP(+)." [EC:1.14.13.93, RHEA:12900]
synonym: "(+)-ABA 8'-hydroxylase activity" EXACT [EC:1.14.13.93]
synonym: "ABA 8'-hydroxylase activity" EXACT [EC:1.14.13.93]
synonym: "ABA 8'-Hydroxylase activity, Abscisate 8'-hydroxylase activity" RELATED []
synonym: "abscisate,NADPH:oxygen oxidoreductase (8'-hydroxylating)" EXACT [EC:1.14.13.93]
synonym: "abscisic acid 8'-hydroxylase activity" EXACT []
xref: EC:1.14.13.93
xref: KEGG:R07202
xref: MetaCyc:1.14.13.93-RXN
xref: RHEA:12900
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0010296
name: prenylcysteine methylesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein C-terminal S-farnesyl-L-cysteine methyl ester + H2O = protein C-terminal S-farnesyl-L-cysteine + methanol + H+." [MetaCyc:RXN-8409, PMID:16870359]
xref: EC:3.1.1.-
xref: MetaCyc:RXN-8409
is_a: GO:0051723 ! protein methylesterase activity

[Term]
id: GO:0010297
name: heteropolysaccharide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with heteropolysaccharides. A heteropolysaccharide is a glycan composed of more than one type of monosaccharide residue." [PMID:16640603]
synonym: "heteroglycan binding" EXACT [GOC:curators]
is_a: GO:0030247 ! polysaccharide binding

[Term]
id: GO:0010298
name: dihydrocamalexic acid decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: dihydrocamalexic acid = camalexin + CO2 + H+." [MetaCyc:RXN-8275, PMID:16766671]
xref: MetaCyc:RXN-8275
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0010299
name: detoxification of cobalt ion
namespace: biological_process
def: "Any process that reduces or removes the toxicity of cobalt ion. These include transport of cobalt away from sensitive areas and to compartments or complexes whose purpose is sequestration of cobalt ion." [GOC:tair_curators]
is_a: GO:0061687 ! detoxification of inorganic compound
relationship: part_of GO:0010043 ! response to zinc ion

[Term]
id: GO:0010301
name: xanthoxin dehydrogenase activity
namespace: molecular_function
alt_id: GO:0033710
def: "Catalysis of the reaction: NAD(+) + xanthoxin = (+)-abscisic aldehyde + H(+) + NADH." [EC:1.1.1.288, RHEA:12551]
synonym: "ABA2" RELATED [EC:1.1.1.288]
synonym: "xanthoxin oxidase activity" EXACT [EC:1.1.1.288]
synonym: "xanthoxin:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.288]
xref: EC:1.1.1.288
xref: KEGG:R06954
xref: MetaCyc:1.1.1.288-RXN
xref: RHEA:12551
is_a: GO:0004022 ! alcohol dehydrogenase (NAD) activity

[Term]
id: GO:0010303
name: limit dextrinase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1,6)-alpha-D-glucosidic linkages in alpha- and beta-limit dextrins of amylopectin and glycogen, and in amylopectin and pullulan." [EC:3.2.1.142]
synonym: "amylopectin-1,6-glucosidase activity" EXACT [EC:3.2.1.142]
synonym: "dextrin alpha-1,6-glucanohydrolase activity" EXACT [EC:3.2.1.142]
synonym: "R-enzyme" RELATED [EC:3.2.1.142]
xref: EC:3.2.1.142
xref: MetaCyc:3.2.1.10-RXN
xref: MetaCyc:3.2.1.142-RXN
xref: MetaCyc:RXN-1824
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0010304
name: PSII associated light-harvesting complex II catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of one or more components of the light-harvesting complex of photosystem II." [GOC:mah, PMID:16157880]
synonym: "LHCII catabolism" RELATED []
is_a: GO:0044257 ! cellular protein catabolic process

[Term]
id: GO:0010305
name: leaf vascular tissue pattern formation
namespace: biological_process
def: "Vascular tissue pattern formation as it occurs in the leaf of vascular plants." [GOC:tair_curators]
is_a: GO:0010051 ! xylem and phloem pattern formation

[Term]
id: GO:0010306
name: rhamnogalacturonan II biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of rhamnogalacturonan II, a low molecular mass (5 - 10KDa) pectic polysaccharide, conserved in the primary walls of dicotyledenous and monocotyledenous plants and gymnosperms." [PMID:12754267]
is_a: GO:0010396 ! rhamnogalacturonan II metabolic process
is_a: GO:0052325 ! cell wall pectin biosynthetic process

[Term]
id: GO:0010307
name: acetylglutamate kinase regulator activity
namespace: molecular_function
def: "Modulates the enzyme activity of acetylglutamate kinase." [PMID:16377628]
is_a: GO:0019207 ! kinase regulator activity
relationship: regulates GO:0003991 ! acetylglutamate kinase activity

[Term]
id: GO:0010308
name: acireductone dioxygenase (Ni2+-requiring) activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O(2) = 3-(methylthio)propanoate + CO + formate." [EC:1.13.11.53, RHEA:14164]
synonym: "1,2-dihydroxy-5-(methylthio)pent-1-en-3-one:oxygen oxidoreductase (formate- and CO-forming)" EXACT [EC:1.13.11.53]
synonym: "2-hydroxy-3-keto-5-thiomethylpent-1-ene dioxygenase activity" BROAD [EC:1.13.11.53]
synonym: "acireductone dioxygenase activity" BROAD [EC:1.13.11.53]
synonym: "ARD activity" RELATED [EC:1.13.11.53]
synonym: "E-2 activity" RELATED [EC:1.13.11.53]
xref: EC:1.13.11.53
xref: KEGG:R07363
xref: MetaCyc:R146-RXN
xref: RHEA:14164
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0010309
name: acireductone dioxygenase [iron(II)-requiring] activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O(2) = 4-methylthio-2-oxobutanoate + formate + H(+)." [EC:1.13.11.54, RHEA:24507]
subset: gosubset_prok
synonym: "1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase activity" EXACT []
synonym: "1,2-dihydroxy-5-(methylthio)pent-1-en-3-one:oxygen oxidoreductase (formate-forming)" EXACT [EC:1.13.11.54]
synonym: "2-hydroxy-3-keto-5-thiomethylpent-1-ene dioxygenase" BROAD []
synonym: "aci-reductone dioxygenase" BROAD []
synonym: "acireductone dioxygenase (Fe2+-requiring) activity" EXACT []
synonym: "acireductone dioxygenase activity" BROAD [EC:1.13.11.54]
synonym: "ARD'" RELATED []
synonym: "ARD1" RELATED []
synonym: "E-2'" RELATED []
xref: EC:1.13.11.54
xref: KEGG:R07364
xref: MetaCyc:R147-RXN
xref: Reactome:REACT_75861 "Acireductone is oxidized to MOB, Homo sapiens"
xref: RHEA:24507
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0010310
name: regulation of hydrogen peroxide metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide." [PMID:14765119]
synonym: "regulation of hydrogen peroxide metabolism" EXACT []
is_a: GO:2000377 ! regulation of reactive oxygen species metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042743 ! hydrogen peroxide metabolic process
relationship: regulates GO:0042743 ! hydrogen peroxide metabolic process

[Term]
id: GO:0010311
name: lateral root formation
namespace: biological_process
alt_id: GO:0010386
def: "The process that gives rise to a lateral root. This process pertains to the initial formation of a structure from unspecified parts. A lateral root primordium represents an organized group of cells derived from the root pericycle that will differentiate into a new root, as opposed to the initiation of the main root from the embryo proper." [GOC:tair_curators, PMID:17259263]
synonym: "lateral root primordium development" EXACT []
is_a: GO:0009791 ! post-embryonic development
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0010102 ! lateral root morphogenesis

[Term]
id: GO:0010312
name: detoxification of zinc ion
namespace: biological_process
def: "Any process that reduces or removes the toxicity of zinc ion. These include transport of zinc away from sensitive areas and to compartments or complexes whose purpose is sequestration of zinc ion." [GOC:tair_curators]
is_a: GO:0098754 ! detoxification
relationship: part_of GO:1990359 ! stress response to zinc ion

[Term]
id: GO:0010313
name: phytochrome binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with phytochrome." [PMID:15486102]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0010314
name: phosphatidylinositol-5-phosphate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with phosphatidylinositol-5-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 5' position." [GOC:bf, GOC:tair_curators]
is_a: GO:1901981 ! phosphatidylinositol phosphate binding

[Term]
id: GO:0010315
name: auxin efflux
namespace: biological_process
def: "The process involved in the transport of auxin out of the cell." [GOC:tair_curators, PMID:16990790]
synonym: "auxin export" EXACT []
is_a: GO:0010928 ! regulation of auxin mediated signaling pathway
is_a: GO:0060918 ! auxin transport
relationship: regulates GO:0009734 ! auxin-activated signaling pathway

[Term]
id: GO:0010316
name: pyrophosphate-dependent phosphofructokinase complex
namespace: cellular_component
def: "Heterodimeric complex that catalyzes the pyrophosphate-dependent phosphorylation of D-fructose 6-phosphate into D-fructose 1,6-bisphosphate." [PMID:2170409]
subset: goslim_pir
synonym: "PFK complex" RELATED []
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0010317
name: pyrophosphate-dependent phosphofructokinase complex, alpha-subunit complex
namespace: cellular_component
def: "Refers to the alpha subunit of the heterodimeric complex that possesses pyrophosphate-dependent phosphofructokinase activity." [PMID:2170409]
synonym: "PFK complex, alpha-subunit" RELATED []
is_a: GO:0043234 ! protein complex
relationship: part_of GO:0010316 ! pyrophosphate-dependent phosphofructokinase complex

[Term]
id: GO:0010318
name: pyrophosphate-dependent phosphofructokinase complex, beta-subunit complex
namespace: cellular_component
def: "Refers to the beta subunit of the heterodimeric complex that possesses pyrophosphate-dependent phosphofructokinase activity." [PMID:2170409]
synonym: "PFK complex, beta-subunit" RELATED []
is_a: GO:0043234 ! protein complex
relationship: part_of GO:0010316 ! pyrophosphate-dependent phosphofructokinase complex

[Term]
id: GO:0010319
name: stromule
namespace: cellular_component
def: "Thin filamentous structure extending from the surface of all plastid types examined so far, including chloroplast, proplastid, etioplast, leucoplast, amyloplast, and chromoplast. In general, stromules are more abundant in tissues containing non-green plastids, and in cells containing smaller plastids. The primary function of stromules is still unresolved, although the presence of stromules markedly increases the plastid surface area, potentially increasing transport to and from the cytosol. Other functions of stromules, such as transfer of macromolecules between plastids and starch granule formation in cereal endosperm, may be restricted to particular tissues and cell types." [PMID:15272881, PMID:15699062, PMID:16582010]
synonym: "Stroma-filled tubule" RELATED []
xref: Wikipedia:Stromule
is_a: GO:0044435 ! plastid part
relationship: part_of GO:0009526 ! plastid envelope

[Term]
id: GO:0010320
name: obsolete arginine/lysine endopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides by a reaction mechanism in which arginine or lysine residues act as nucleophiles." [GOC:tair_curators]
comment: This term was made obsolete because it was defined incorrectly: there are no known peptidases using a catalytic mechanism involving arginine and lysine, and the Arabidopsis metacaspases that prompted addition of this term are in fact cysteine-type endopeptidases.
synonym: "arginine/lysine endopeptidase activity" EXACT []
is_obsolete: true
consider: GO:0004175
consider: GO:0004197

[Term]
id: GO:0010321
name: regulation of vegetative phase change
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vegetative phase change. Vegetative phase change is the set of post-embryonic processes involved in the transition of a plant from a juvenile phase of vegetative development to an adult phase of vegetative development." [GOC:tair_curators]
is_a: GO:0048580 ! regulation of post-embryonic development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010050 ! vegetative phase change
relationship: regulates GO:0010050 ! vegetative phase change

[Term]
id: GO:0010322
name: regulation of isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of isopentenyl diphosphate produced via the methylerythritol (MEP) pathway (mevalonate-independent)." [PMID:16531478]
synonym: "regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway" EXACT []
is_a: GO:0010565 ! regulation of cellular ketone metabolic process
is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process
is_a: GO:0019747 ! regulation of isoprenoid metabolic process
is_a: GO:0071071 ! regulation of phospholipid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019288 ! isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
relationship: regulates GO:0019288 ! isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway

[Term]
id: GO:0010323
name: negative regulation of isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of isopentenyl diphosphate produced via the methylerythritol (MEP) pathway (mevalonate-independent)." [PMID:16531478]
synonym: "down regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway" EXACT []
synonym: "down-regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway" EXACT []
synonym: "downregulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway" EXACT []
synonym: "inhibition of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway" NARROW []
synonym: "negative regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway" EXACT []
is_a: GO:0010322 ! regulation of isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process
is_a: GO:0045827 ! negative regulation of isoprenoid metabolic process
is_a: GO:0071072 ! negative regulation of phospholipid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019288 ! isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
relationship: negatively_regulates GO:0019288 ! isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway

[Term]
id: GO:0010324
name: membrane invagination
namespace: biological_process
def: "The infolding of a membrane, resulting in formation of a vesicle." [GOC:tb]
subset: goslim_yeast
is_a: GO:0061024 ! membrane organization

[Term]
id: GO:0010325
name: raffinose family oligosaccharide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of raffinose family oligosaccharides (RFOs, such as raffinose, stachyose, verbascose and other molecules with a higher degree of galactosyl polymerization)." [GOC:tair_curators]
synonym: "raffinose family oligosaccharide biosynthesis" EXACT []
is_a: GO:0009312 ! oligosaccharide biosynthetic process

[Term]
id: GO:0010326
name: methionine-oxo-acid transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: methionine + a 2-oxo acid = 2-oxo-4-methylthiobutanoate + an amino acid." [MetaCyc:RXN-2201, PMID:17056707]
xref: EC:2.6.1.-
xref: MetaCyc:RXN-2201
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0010327
name: acetyl CoA:(Z)-3-hexen-1-ol acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + (Z)-3-hexen-1-ol = CoA + (Z)-3-hexen-1-yl acetate." [PMID:17163883]
synonym: "hexenol acetyltransferase" RELATED []
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0010328
name: auxin influx transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of auxin, from one side of a membrane to the other, into a cell." [PMID:16839804]
synonym: "auxin influx facilitator" RELATED []
is_a: GO:0080161 ! auxin transmembrane transporter activity
relationship: part_of GO:0060919 ! auxin influx

[Term]
id: GO:0010329
name: auxin efflux transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of auxin, from one side of a membrane to the other, out of a cell." [PMID:16839804]
synonym: "auxin efflux carrier" RELATED []
synonym: "auxin efflux facilitator" RELATED []
is_a: GO:0015562 ! efflux transmembrane transporter activity
is_a: GO:0080161 ! auxin transmembrane transporter activity
relationship: part_of GO:0010315 ! auxin efflux

[Term]
id: GO:0010330
name: cellulose synthase complex
namespace: cellular_component
def: "A large, multimeric protein complex, organized in a rosette, which catalyzes the biosynthesis of cellulose for the plant cell wall." [PMID:12514238, PMID:18485800, PMID:21307367]
synonym: "CESA complex" EXACT []
is_a: GO:1990234 ! transferase complex

[Term]
id: GO:0010331
name: gibberellin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with gibberellins, plant hormones that regulate aspects of plant growth." [GOC:tair_curators]
synonym: "gibberellic acid receptor" RELATED []
synonym: "gibberellin receptor" RELATED []
is_a: GO:0019840 ! isoprenoid binding
is_a: GO:0031406 ! carboxylic acid binding
is_a: GO:0042562 ! hormone binding

[Term]
id: GO:0010332
name: response to gamma radiation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum." [GOC:tair_curators, Wikipedia:Gamma_ray]
synonym: "response to gamma ray" RELATED []
synonym: "response to gamma-ray photon" RELATED []
is_a: GO:0010212 ! response to ionizing radiation

[Term]
id: GO:0010333
name: terpene synthase activity
namespace: molecular_function
def: "Catalysis of the formation of cyclic terpenes through the cyclization of linear terpenes (e.g. isopentenyl-PP, geranyl-PP, farnesyl-PP and geranylgeranyl-PP) containing varying numbers of isoprene units." [EC:4.2.3.-, GOC:tair_curators]
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0010334
name: sesquiterpene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans,trans-farnesyl diphosphate = a sesquiterpene + diphosphate. Sesquiterpenes are terpenes containing three isoprene units, i.e. 15 carbons." [EC:4.2.3.-, GOC:tair_curators]
is_a: GO:0010333 ! terpene synthase activity

[Term]
id: GO:0010335
name: response to non-ionic osmotic stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of non-ionic solutes (e.g. mannitol, sorbitol) in the environment." [GOC:tair_curators]
is_a: GO:0006970 ! response to osmotic stress

[Term]
id: GO:0010336
name: gibberellic acid homeostasis
namespace: biological_process
def: "Any biological process involved in the maintenance of an internal steady state of gibberellic acid; may involve transport, biosynthesis, catabolism or conjugation." [PMID:17194763]
synonym: "gibberellin homeostasis" BROAD []
is_a: GO:0055081 ! anion homeostasis
is_a: GO:0055088 ! lipid homeostasis

[Term]
id: GO:0010337
name: regulation of salicylic acid metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving salicylic acid." [PMID:14765119]
synonym: "regulation of salicylic acid metabolism" RELATED []
is_a: GO:0010565 ! regulation of cellular ketone metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009696 ! salicylic acid metabolic process
relationship: regulates GO:0009696 ! salicylic acid metabolic process

[Term]
id: GO:0010338
name: leaf formation
namespace: biological_process
def: "The process that gives rise to a leaf. This process pertains to the initial formation of a structure from unspecified parts." [GOC:tair_curators]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
is_a: GO:0099402 ! plant organ development
relationship: part_of GO:0009965 ! leaf morphogenesis

[Term]
id: GO:0010339
name: external side of cell wall
namespace: cellular_component
def: "The side of the cell wall that is opposite to the side that faces the cell and its contents." [GOC:mtg_sensu, GOC:tb]
is_a: GO:0044426 ! cell wall part
relationship: part_of GO:0009986 ! cell surface

[Term]
id: GO:0010340
name: carboxyl-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group to the carboxyl group of an acceptor molecule to form a methyl ester." [PMID:17220201]
is_a: GO:0008171 ! O-methyltransferase activity

[Term]
id: GO:0010341
name: gibberellin carboxyl-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + a gibberellin = S-adenosyl-L-homocysteine + a gibberellin methyl ester." [PMID:17220201]
is_a: GO:0010340 ! carboxyl-O-methyltransferase activity

[Term]
id: GO:0010342
name: endosperm cellularization
namespace: biological_process
def: "The separation of the multi-nucleate endosperm into individual cells. In many plant species, the endosperm that nurtures the embryo in the seed initially develops as a syncytium. This syncytial phase ends with simultaneous partitioning of the multi-nucleate cytoplasm into individual cells, a process referred to as cellularization." [PMID:12421698]
synonym: "cellularization of endosperm" EXACT []
is_a: GO:0007349 ! cellularization

[Term]
id: GO:0010343
name: singlet oxygen-mediated programmed cell death
namespace: biological_process
def: "Programmed cell death induced by singlet oxygen. Programmed cell death is the cell death resulting from activation of endogenous cellular processes." [GOC:mtg_apoptosis, PMID:17075038]
synonym: "light-dependent programmed cell death" BROAD []
synonym: "programmed cell death in response to singlet oxygen" EXACT []
is_a: GO:0097468 ! programmed cell death in response to reactive oxygen species
relationship: part_of GO:0071452 ! cellular response to singlet oxygen

[Term]
id: GO:0010344
name: seed oilbody biogenesis
namespace: biological_process
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a seed oilbody. Seed oilbodies are simple organelles comprising a matrix of triglyceride surrounded by a phospholipid monolayer embedded and covered with unique proteins called oleosins. Seed oilbodies supply the energy requirements for the growth of the seedling after germination." [GOC:jl, PMID:16877495]
synonym: "oleosome biogenesis" RELATED []
synonym: "seed oil body organization" EXACT []
synonym: "spherosome biogenesis" RELATED []
is_a: GO:0022414 ! reproductive process
is_a: GO:0044085 ! cellular component biogenesis
relationship: part_of GO:0048316 ! seed development

[Term]
id: GO:0010345
name: suberin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of suberin monomers and suberin polyesters. Suberin monomers are derived from fatty acids and trans-cinnamic acids. The monomers are then cross-linked with glycerols." [PMID:17259262]
xref: MetaCyc:PWY-1121
is_a: GO:0009699 ! phenylpropanoid biosynthetic process

[Term]
id: GO:0010346
name: shoot axis formation
namespace: biological_process
def: "The process that gives rise to a shoot axis. This process pertains to the initial formation of a structure from unspecified parts." [GOC:tb]
synonym: "shoot formation" RELATED []
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0010016 ! shoot system morphogenesis

[Term]
id: GO:0010347
name: L-galactose-1-phosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-galactose-1-phosphate + H2O = L-galactose + phosphate." [PMID:15550539, PMID:16595667]
xref: MetaCyc:RXNQT-4142
is_a: GO:0070456 ! galactose-1-phosphate phosphatase activity

[Term]
id: GO:0010348
name: lithium:proton antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Li+(in) + H+(out) = Li+(out) + H+(in)." [PMID:17270011]
synonym: "lithium:hydrogen antiporter activity" EXACT []
is_a: GO:0005451 ! monovalent cation:proton antiporter activity

[Term]
id: GO:0010349
name: L-galactose dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-galactose + NAD+ = L-galactono-1,4-lactone + NADH + H+." [PMID:12047629]
synonym: "L-galactose 1-dehydrogenase activity" RELATED []
xref: MetaCyc:RXN-1884
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0010350
name: cellular response to magnesium starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of magnesium." [PMID:17270009]
is_a: GO:0009267 ! cellular response to starvation

[Term]
id: GO:0010351
name: lithium ion transport
namespace: biological_process
def: "The directed movement of lithium ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [PMID:17270011]
synonym: "lithium transport" EXACT []
is_a: GO:0015672 ! monovalent inorganic cation transport
is_a: GO:0030001 ! metal ion transport

[Term]
id: GO:0010352
name: lithium ion export
namespace: biological_process
def: "The directed movement of lithium ion out of a cell or organelle." [PMID:17270011]
synonym: "lithium export" EXACT []
synonym: "lithium ion efflux" RELATED []
is_a: GO:0010351 ! lithium ion transport

[Term]
id: GO:0010353
name: response to trehalose
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trehalose stimulus." [PMID:17031512]
synonym: "response to trehalose stimulus" EXACT [GOC:dos]
is_a: GO:0034285 ! response to disaccharide

[Term]
id: GO:0010354
name: homogentisate prenyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a prenyl group from one compound (donor) to homogentisic acid." [PMID:16989822]
is_a: GO:0004659 ! prenyltransferase activity

[Term]
id: GO:0010355
name: homogentisate farnesyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: homogentisic acid + farnesyl diphosphate = 2-methyl-6-farnesylplastoquinol." [PMID:16989822]
is_a: GO:0010354 ! homogentisate prenyltransferase activity

[Term]
id: GO:0010356
name: homogentisate geranylgeranyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: homogentisic acid + geranylgeranyl diphosphate = 2-methyl-6-geranylgeranylplastoquinol." [PMID:16989822]
is_a: GO:0010354 ! homogentisate prenyltransferase activity

[Term]
id: GO:0010357
name: homogentisate solanesyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: homogentisic acid + all-trans-nonaprenyl diphosphate + 3 H+ = 2-methyl-6-solanyl-1,4-benzoquinonone + CO2 + diphosphate. 2-methyl-6-solanyl-1,4-benzoquinonone is also known as 2-methyl-6-solanesylplastoquinol and all-trans-nonaprenyl diphosphate as solanesyl diphosphate." [PMID:16989822]
is_a: GO:0010354 ! homogentisate prenyltransferase activity

[Term]
id: GO:0010358
name: leaf shaping
namespace: biological_process
def: "The developmental process that pertains to the organization of a leaf in three-dimensional space once the structure has initially formed." [GOC:tb, PMID:16971475]
synonym: "leaf structural organization" RELATED []
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0009965 ! leaf morphogenesis

[Term]
id: GO:0010359
name: regulation of anion channel activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of anion channel activity." [PMID:17319842]
subset: gosubset_prok
is_a: GO:0032412 ! regulation of ion transmembrane transporter activity
is_a: GO:1903959 ! regulation of anion transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0005253 ! anion channel activity
relationship: regulates GO:0005253 ! anion channel activity

[Term]
id: GO:0010360
name: negative regulation of anion channel activity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the anion channel activity." [PMID:17319842]
is_a: GO:0010359 ! regulation of anion channel activity
is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity
is_a: GO:1903960 ! negative regulation of anion transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0005253 ! anion channel activity
relationship: negatively_regulates GO:0005253 ! anion channel activity

[Term]
id: GO:0010361
name: regulation of anion channel activity by blue light
namespace: biological_process
def: "Any process in which blue light modulates the frequency, rate or extent of anion channel activity." [GOC:dph, GOC:tb, PMID:17319842]
synonym: "regulation by blue light of anion channel activity" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010359 ! regulation of anion channel activity

[Term]
id: GO:0010362
name: negative regulation of anion channel activity by blue light
namespace: biological_process
def: "Any process in which blue light stops, prevents, or reduces the frequency, rate, or extent of the anion channel activity." [PMID:17319842]
synonym: "inhibition by blue light of anion channel activity" NARROW []
synonym: "negative regulation by blue light of anion channel activity" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010360 ! negative regulation of anion channel activity
is_a: GO:0010361 ! regulation of anion channel activity by blue light

[Term]
id: GO:0010363
name: regulation of plant-type hypersensitive response
namespace: biological_process
def: "Any endogenous process that modulates the frequency, rate or extent of the plant hypersensitive response." [PMID:16255244]
comment: Note that term is to be used to annotate gene products in the plant. To annotate genes in a symbiont, consider the biological process term 'modulation by symbiont of host programmed cell death ; GO:0052040'.
synonym: "regulation of HR" EXACT []
synonym: "regulation of HR-PCD" EXACT []
synonym: "regulation of plant hypersensitive response" EXACT []
is_a: GO:0043067 ! regulation of programmed cell death
is_a: GO:0045088 ! regulation of innate immune response
is_a: GO:0080135 ! regulation of cellular response to stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009626 ! plant-type hypersensitive response
relationship: regulates GO:0009626 ! plant-type hypersensitive response

[Term]
id: GO:0010364
name: regulation of ethylene biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an ethylene biosynthetic process." [GOC:tair_curators]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0031335 ! regulation of sulfur amino acid metabolic process
is_a: GO:1900911 ! regulation of olefin biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009693 ! ethylene biosynthetic process
relationship: regulates GO:0009693 ! ethylene biosynthetic process

[Term]
id: GO:0010365
name: positive regulation of ethylene biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of an ethylene biosynthetic process." [GOC:tair_curators]
is_a: GO:0010364 ! regulation of ethylene biosynthetic process
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0031337 ! positive regulation of sulfur amino acid metabolic process
is_a: GO:1900913 ! positive regulation of olefin biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009693 ! ethylene biosynthetic process
relationship: positively_regulates GO:0009693 ! ethylene biosynthetic process

[Term]
id: GO:0010366
name: negative regulation of ethylene biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of an ethylene biosynthetic process." [GOC:tair_curators]
is_a: GO:0010364 ! regulation of ethylene biosynthetic process
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0031336 ! negative regulation of sulfur amino acid metabolic process
is_a: GO:1900912 ! negative regulation of olefin biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009693 ! ethylene biosynthetic process
relationship: negatively_regulates GO:0009693 ! ethylene biosynthetic process

[Term]
id: GO:0010367
name: extracellular isoamylase complex
namespace: cellular_component
def: "A protein complex whose composition varies amongst species; in rice it probably exists in a homo-tetramer to homo-hexamer form and in Gram negative bacteria as a dimer. Functions in the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages. Isoamylases in animals are localized in the extracellular space." [GOC:tair_curators]
subset: gosubset_prok
is_a: GO:0043033 ! isoamylase complex
is_a: GO:0044421 ! extracellular region part
intersection_of: GO:0043033 ! isoamylase complex
intersection_of: part_of GO:0005576 ! extracellular region
relationship: part_of GO:0005576 ! extracellular region

[Term]
id: GO:0010368
name: chloroplast isoamylase complex
namespace: cellular_component
def: "A protein complex whose composition varies amongst species; in rice it probably exists in a homo-tetramer to homo-hexamer form and in Gram negative bacteria as a dimer. Functions in the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages. Isoamylases in plants are intracellular and probably chloroplast localized." [GOC:tair_curators]
subset: gosubset_prok
is_a: GO:0043033 ! isoamylase complex
is_a: GO:0044434 ! chloroplast part
intersection_of: GO:0043033 ! isoamylase complex
intersection_of: part_of GO:0009507 ! chloroplast
relationship: part_of GO:0009507 ! chloroplast

[Term]
id: GO:0010369
name: chromocenter
namespace: cellular_component
def: "A region in which centric, heterochromatic portions of one or more chromosomes form a compact structure." [PMID:12384572, PMID:15053486, PMID:16831888]
is_a: GO:0098687 ! chromosomal region

[Term]
id: GO:0010370
name: perinucleolar chromocenter
namespace: cellular_component
def: "A chromocenter adjacent to the nucleolus." [PMID:15805479]
is_a: GO:0010369 ! chromocenter

[Term]
id: GO:0010371
name: regulation of gibberellin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of gibberellins." [GOC:tair_curators]
synonym: "regulation of gibberellic acid biosynthetic process" NARROW []
is_a: GO:0010565 ! regulation of cellular ketone metabolic process
is_a: GO:0019747 ! regulation of isoprenoid metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0043455 ! regulation of secondary metabolic process
is_a: GO:0046890 ! regulation of lipid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009686 ! gibberellin biosynthetic process
relationship: regulates GO:0009686 ! gibberellin biosynthetic process

[Term]
id: GO:0010372
name: positive regulation of gibberellin biosynthetic process
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of gibberellins." [GOC:tair_curators]
synonym: "positive regulation of gibberellic acid biosynthetic process" NARROW []
is_a: GO:0010371 ! regulation of gibberellin biosynthetic process
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process
is_a: GO:0046889 ! positive regulation of lipid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009686 ! gibberellin biosynthetic process
relationship: positively_regulates GO:0009686 ! gibberellin biosynthetic process

[Term]
id: GO:0010373
name: negative regulation of gibberellin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of gibberellins." [GOC:tair_curators]
synonym: "negative regulation of gibberellic acid biosynthetic process" NARROW []
is_a: GO:0010371 ! regulation of gibberellin biosynthetic process
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0045827 ! negative regulation of isoprenoid metabolic process
is_a: GO:0051055 ! negative regulation of lipid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009686 ! gibberellin biosynthetic process
relationship: negatively_regulates GO:0009686 ! gibberellin biosynthetic process

[Term]
id: GO:0010374
name: stomatal complex development
namespace: biological_process
def: "The process whose specific outcome is the progression of the stomatal complex over time from its formation to the mature structure. The stomatal complex is the stomatal guard cells and their associated epidermal cells." [PMID:17259259]
is_a: GO:0009791 ! post-embryonic development
is_a: GO:0090558 ! plant epidermis development

[Term]
id: GO:0010375
name: stomatal complex patterning
namespace: biological_process
def: "The regionalization process of establishing the non-random spatial arrangement of stomatal complex on the surface of a leaf. The stomatal complex is the stomatal guard cells and their associated epidermal cells." [PMID:17259259]
is_a: GO:0003002 ! regionalization

[Term]
id: GO:0010376
name: stomatal complex formation
namespace: biological_process
def: "The process that gives rise to the stomatal complex. This process pertains to the initial formation of a structure from unspecified parts. The stomatal complex is the stomatal guard cells and their associated epidermal cells." [PMID:17259259]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0010103 ! stomatal complex morphogenesis

[Term]
id: GO:0010377
name: guard cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a stomatal guard cell. Guard cells are located in the leaf epidermis and pairwise surround stomatal pores, which allow CO2 influx for photosynthetic carbon fixation and water loss via transpiration to the atmosphere." [PMID:17259259]
synonym: "stomatal cell fate commitment" RELATED []
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0010052 ! guard cell differentiation

[Term]
id: GO:0010378
name: temperature compensation of the circadian clock
namespace: biological_process
def: "The process in which the circadian clock maintains robust and accurate timing over a broad range of physiological temperatures. The circadian clock is an endogenous 24-h timer found in most eukaryotes and in photosynthetic bacteria. The clock drives rhythms in the physiology, biochemistry, and metabolism of the organisms." [PMID:16617099]
subset: gosubset_prok
synonym: "regulation of the circadian clock by temperature" RELATED []
is_a: GO:0009266 ! response to temperature stimulus
is_a: GO:0042752 ! regulation of circadian rhythm

[Term]
id: GO:0010379
name: phaseic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phaseic acid (PA), a catabolite of the plant hormone abscisic acid (ABA)." [BioCyc:PWY-5271]
xref: MetaCyc:PWY-5271
is_a: GO:0016106 ! sesquiterpenoid biosynthetic process
is_a: GO:0043289 ! apocarotenoid biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process

[Term]
id: GO:0010380
name: regulation of chlorophyll biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors." [PMID:17291312]
is_a: GO:0090056 ! regulation of chlorophyll metabolic process
is_a: GO:1901463 ! regulation of tetrapyrrole biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0015995 ! chlorophyll biosynthetic process
relationship: regulates GO:0015995 ! chlorophyll biosynthetic process

[Term]
id: GO:0010381
name: attachment of peroxisome to chloroplast
namespace: biological_process
def: "The process in which a peroxisome is transported to, and/or maintained in, a location adjacent to the chloroplast." [PMID:17215364]
is_a: GO:0051640 ! organelle localization

[Term]
id: GO:0010383
name: cell wall polysaccharide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cell wall polysaccharides." [GOC:tair_curators]
subset: gosubset_prok
is_a: GO:0005976 ! polysaccharide metabolic process
is_a: GO:0044036 ! cell wall macromolecule metabolic process

[Term]
id: GO:0010384
name: cell wall proteoglycan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cell wall peptidoglycan, a group of glycoproteins that consist of a core-protein backbone O-glycosylated by one or more complex carbohydrates." [GOC:tair_curators]
synonym: "cell wall proteoglycan metabolism" EXACT []
is_a: GO:0006029 ! proteoglycan metabolic process
is_a: GO:0044036 ! cell wall macromolecule metabolic process

[Term]
id: GO:0010385
name: double-stranded methylated DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with double-stranded methylated DNA. Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks." [GOC:imk, PMID:17242155]
is_a: GO:0003690 ! double-stranded DNA binding

[Term]
id: GO:0010387
name: COP9 signalosome assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a COP9 signalosome." [PMID:17307927]
synonym: "signalosome assembly" BROAD [GOC:krc]
is_a: GO:0043623 ! cellular protein complex assembly

[Term]
id: GO:0010388
name: cullin deneddylation
namespace: biological_process
def: "The modification of cullins by removal of ubiquitin-like protein NEDD8 (RUB1)." [PMID:17307927]
is_a: GO:0000338 ! protein deneddylation

[Term]
id: GO:0010389
name: regulation of G2/M transition of mitotic cell cycle
namespace: biological_process
def: "Any process that modulates the rate or extent of progression from G2 phase to M phase of the mitotic cell cycle." [GOC:mtg_cell_cycle, PMID:17329565]
synonym: "regulation of mitotic entry" EXACT [GOC:vw]
is_a: GO:1901990 ! regulation of mitotic cell cycle phase transition
is_a: GO:1902749 ! regulation of cell cycle G2/M phase transition
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000086 ! G2/M transition of mitotic cell cycle
relationship: regulates GO:0000086 ! G2/M transition of mitotic cell cycle

[Term]
id: GO:0010390
name: histone monoubiquitination
namespace: biological_process
def: "The modification of histones by addition of a single ubiquitin group." [PMID:17329563]
is_a: GO:0006513 ! protein monoubiquitination
is_a: GO:0016574 ! histone ubiquitination

[Term]
id: GO:0010391
name: glucomannan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glucomannan, a polysaccharide composed of D-glucose and D-mannose. The mannose units form the backbone structure (a linear main chain) with the D-glucose as single side-units." [GOC:tair_curators]
synonym: "glucomannan metabolism" EXACT []
is_a: GO:0006080 ! substituted mannan metabolic process

[Term]
id: GO:0010392
name: galactoglucomannan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving galactoglucomannan, a polysaccharide composed of D-glucose, D-galactose and D-mannose. The mannose units form the backbone structure (a linear main chain) decorated with a mixture of D-glucose and D-galactose side-units." [GOC:tair_curators]
synonym: "galactoglucomannan metabolism" RELATED []
is_a: GO:0006080 ! substituted mannan metabolic process

[Term]
id: GO:0010393
name: galacturonan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving galacturonan, a pectin polymer containing a backbone of alpha-(1->4)-linked D-galacturonic acid residues." [GOC:tair_curators]
synonym: "galacturonan metabolism" EXACT []
is_a: GO:0005976 ! polysaccharide metabolic process

[Term]
id: GO:0010394
name: homogalacturonan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving homogalacturonan, a pectin characterized by a backbone of alpha-(1->4)-linked D-galacturonic acid residues that can be methyl-esterified at C-6 and carry acetyl groups on O-2 and O-3." [GOC:tair_curators]
synonym: "homogalacturonan metabolism" EXACT []
is_a: GO:0010393 ! galacturonan metabolic process

[Term]
id: GO:0010395
name: rhamnogalacturonan I metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving rhamnogalacturonan I (RGI), a branched pectin with a backbone of alternating alpha-(1->2)-linked rhamnose and alpha-(1->4)-linked D-galacturonic acid residues that carries neutral side-chains of predominantly beta-(1->4)-D-galactose and/or alpha-(1->5)-L-arabinose residues attached to the rhamnose residues of the RGI backbone." [GOC:tair_curators]
synonym: "RGI metabolism" RELATED []
synonym: "rhamnogalacturonan I metabolism" EXACT []
is_a: GO:0044036 ! cell wall macromolecule metabolic process
is_a: GO:0044264 ! cellular polysaccharide metabolic process
is_a: GO:0052546 ! cell wall pectin metabolic process

[Term]
id: GO:0010396
name: rhamnogalacturonan II metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving rhamnogalacturonan II, a low molecular mass (5-10KDa) pectic polysaccharide. The backbone of RG-II contains at least 8 1,4-linked alpha-D-GalpA residues." [GOC:tair_curators]
synonym: "rhamnogalacturonan II metabolism" EXACT []
is_a: GO:0010393 ! galacturonan metabolic process

[Term]
id: GO:0010397
name: apiogalacturonan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the pectic apiogalacturonan, characterized by a backbone of alpha-(1->4)-linked D-galacturonic acid residues substituted with apiose and apiobiose (D-apiofuranosyl-beta-(1->3)-D-apiose) side chains via O-2 or O-3 links." [GOC:tair_curators]
synonym: "apiogalacturonan metabolism" EXACT []
is_a: GO:0005976 ! polysaccharide metabolic process
is_a: GO:0044723 ! single-organism carbohydrate metabolic process

[Term]
id: GO:0010398
name: xylogalacturonan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving xylogalacturonan, a pectin characterized by a backbone of alpha-(1->4)-linked D-galacturonic acid residues substituted on C-3 with beta-D-xylopyranose residues." [GOC:tair_curators]
synonym: "xylogalacturonan metabolism" EXACT []
is_a: GO:0010393 ! galacturonan metabolic process

[Term]
id: GO:0010399
name: rhamnogalacturonan I backbone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the alternating alpha-(1->2)-linked rhamnose and alpha-(1->2)-linked B-galacturonic acid residues of the rhamnogalacturonan I backbone." [GOC:tair_curators]
synonym: "rhamnogalacturonan I backbone metabolism" EXACT []
is_a: GO:0010395 ! rhamnogalacturonan I metabolic process

[Term]
id: GO:0010400
name: rhamnogalacturonan I side chain metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the side chains of the pectin, rhamnogalacturonan I." [GOC:tair_curators]
synonym: "rhamnogalacturonan I side chain metabolism" EXACT []
is_a: GO:0010395 ! rhamnogalacturonan I metabolic process

[Term]
id: GO:0010401
name: pectic galactan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving galactan, a polymer of D-galactosyl units that can be found as a side chain of the pectin rhamnogalacturonan I." [GOC:tair_curators]
synonym: "pectic galactan metabolism" EXACT []
is_a: GO:0010400 ! rhamnogalacturonan I side chain metabolic process

[Term]
id: GO:0010402
name: pectic arabinan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pectic arabinan, a polymer with an alpha-(1->5)-linked L-arabinofuranose (Araf) backbone that can be substituted with Araf-alpha-(1->2)-, Araf-alpha-(1->3)-, and/or Araf-alpha-(1->3)-Araf-alpha-(1->3)-side chains. Arabinan can be found as a side chain of the pectin rhamnogalacturonan I." [GOC:tair_curators]
synonym: "pectic arabinan metabolism" EXACT []
is_a: GO:0010400 ! rhamnogalacturonan I side chain metabolic process

[Term]
id: GO:0010403
name: pectic arabinogalactan I metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pectic arabinogalactan I, an alpha-(1,4)-linked D-galactopyranose backbone that is substituted with alpha-l-Araf residues via the O-3 of the D-galactose residues. Arabinogalactan I can be found as a side chain of rhamnogalacturonan I." [GOC:tair_curators]
synonym: "pectic arabinogalactan I metabolism" EXACT []
is_a: GO:0010400 ! rhamnogalacturonan I side chain metabolic process

[Term]
id: GO:0010404
name: cell wall hydroxyproline-rich glycoprotein metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a cell wall hydroxyproline-rich glycoprotein that consist of a core-protein backbone O-glycosylated by one or more complex carbohydrates." [GOC:tair_curators]
synonym: "cell wall hydroxyproline-rich glycoprotein metabolism" EXACT []
is_a: GO:0010384 ! cell wall proteoglycan metabolic process

[Term]
id: GO:0010405
name: arabinogalactan protein metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a cell wall arabinogalactan II glycoprotein, which is composed of a group of core protein of highly varying length and domain complexity. These are O-glycosylated at one or more hydroxyproline residues by arabinogalactan (AG) type II groups, which consist of (1->3)-beta-galactan and (1->6)-beta-linked galactan chains connected to each other by (1->3,1->6)-linked branch points, O-3 and O-6 positions substituted with terminal arabinosyl residues. Also, rhamnose, fucose, glucuronic and galacturonic acid can be present in the glycan structures." [GOC:tair_curators]
synonym: "arabinogalactan protein metabolism" EXACT []
is_a: GO:0010404 ! cell wall hydroxyproline-rich glycoprotein metabolic process

[Term]
id: GO:0010406
name: classical arabinogalactan protein metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a cell wall arabinogalactan II glycoprotein, which is composed of a group of core protein containing Hyp, Ala, Ser, Thr and Gly as the major amino acid constituents, and the C-terminus is GPI anchored." [GOC:tair_curators]
synonym: "classical-arabinogalactan protein metabolism" EXACT []
is_a: GO:0010405 ! arabinogalactan protein metabolic process

[Term]
id: GO:0010407
name: non-classical arabinogalactan protein metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a cell wall arabinogalactan II glycoprotein where other amino acids besides Hyp, Ala, Ser, Thr and Gly can be present and grouped into regions, such as a Cys-rich or Asn-rich domains." [GOC:tair_curators]
synonym: "non-classical arabinogalactan protein metabolism" EXACT []
is_a: GO:0010405 ! arabinogalactan protein metabolic process

[Term]
id: GO:0010408
name: fasciclin-like arabinogalactan protein metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the cell wall arabinogalactan II glycoprotein variant which contains both an arabinogalactan protein (AGP) motif and a fasciclin domain." [GOC:tair_curators]
synonym: "fasciclin-like arabinogalactan protein metabolism" EXACT []
is_a: GO:0010405 ! arabinogalactan protein metabolic process

[Term]
id: GO:0010409
name: extensin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving extensins, a group of 60-90 kDNA hydroxyproline (Hyp)-rich glycoproteins whose polypeptide backbone consists of many repeats of structural Ser(Hyp)4-6 motifs, with heavily glycosylated 1-4 arabinose residues O-linked to contiguous stretches of Hyp residues, with most of the Ser residues being O-galactosylated." [GOC:tair_curators]
synonym: "extensin metabolism" EXACT []
is_a: GO:0010404 ! cell wall hydroxyproline-rich glycoprotein metabolic process

[Term]
id: GO:0010410
name: hemicellulose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving hemicelluloses, plant cell wall polysaccharides that have a backbone of 1,4-linked beta-D-pyranosyl residues in which O4 is in the equatorial orientation. Many different hemicelluloses usually occur intermixed with each molecular type representing different degrees of polymerization and contain many different sugar monomers, which can include glucose, xylose, mannose, galactose, and arabinose. Hemicelluloses also contain most of the D-pentose sugars and occasionally small amounts of L-sugars as well. Xylose is always the sugar monomer present in the largest amount, but mannuronic acid and galacturonic acid also tend to be present." [GOC:tair_curators]
subset: gosubset_prok
synonym: "hemicellulose metabolism" EXACT []
is_a: GO:0010383 ! cell wall polysaccharide metabolic process

[Term]
id: GO:0010411
name: xyloglucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving xyloglucan, the cross-linking glycan composed of (1->4)-beta-D-glucan backbone substituted at regular intervals with beta-D-xylosyl-(1->6) residues, which is present in the primary cell wall of most higher plants." [GOC:tair_curators]
synonym: "xyloglucan metabolism" EXACT [GOC:obol]
is_a: GO:0006073 ! cellular glucan metabolic process
is_a: GO:0010410 ! hemicellulose metabolic process

[Term]
id: GO:0010412
name: mannan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mannan, a group of polysaccharides containing a backbone composed of a polymer of D-mannose units." [GOC:tair_curators]
subset: gosubset_prok
synonym: "mannan metabolism" EXACT []
is_a: GO:0044036 ! cell wall macromolecule metabolic process
is_a: GO:0044264 ! cellular polysaccharide metabolic process

[Term]
id: GO:0010413
name: glucuronoxylan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving xylan, a polymer containing a beta-(1->4)-linked D-xylose backbone decorated with glucuronic acid side units." [GOC:tair_curators]
synonym: "glucuronoxylan metabolism" EXACT []
is_a: GO:0045491 ! xylan metabolic process

[Term]
id: GO:0010414
name: glucuronoarabinoxylan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving xylan, a polymer containing a beta-(1->4)-linked D-xylose backbone decorated with glucuronic acid and arabinose side units." [GOC:tair_curators]
synonym: "glucuronoarabinoxylan metabolism" EXACT []
is_a: GO:0010413 ! glucuronoxylan metabolic process
is_a: GO:0010416 ! arabinoxylan-containing compound metabolic process

[Term]
id: GO:0010415
name: unsubstituted mannan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the mannan backbone, the unsubstituted polymer of D-mannose units." [GOC:tair_curators]
synonym: "unsubstituted mannan metabolism" EXACT []
is_a: GO:0010412 ! mannan metabolic process

[Term]
id: GO:0010416
name: arabinoxylan-containing compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an arabinoxylan, a polymer containing a beta-1,4-linked D-xylose backbone decorated with arabinose side units." [GOC:tair_curators]
synonym: "arabinoxylan metabolic process" RELATED []
synonym: "arabinoxylan metabolism" RELATED []
is_a: GO:0045491 ! xylan metabolic process

[Term]
id: GO:0010417
name: glucuronoxylan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glucuronoxylan, a polymer containing a beta-1,4-linked D-xylose backbone substituted with glucuronic acid residues." [GOC:tair_curators]
synonym: "glucuronoxylan anabolism" EXACT []
synonym: "glucuronoxylan biosynthesis" EXACT []
synonym: "glucuronoxylan formation" EXACT []
synonym: "glucuronoxylan synthesis" EXACT []
is_a: GO:0010413 ! glucuronoxylan metabolic process
is_a: GO:0045492 ! xylan biosynthetic process

[Term]
id: GO:0010418
name: rhamnogalacturonan II backbone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the backbone structure of pectic rhamnogalacturonan II. The back bone contains at least 8 1,4-linked alpha-D-GalpA residues." [GOC:tair_curators]
synonym: "rhamnogalacturonan II backbone metabolism" EXACT []
is_a: GO:0010394 ! homogalacturonan metabolic process
is_a: GO:0010396 ! rhamnogalacturonan II metabolic process

[Term]
id: GO:0010419
name: rhamnogalacturonan II side chain metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the side chains of pectic rhamnogalacturonan II. A number of structurally distinct di- and oligosaccharides can be attached to the C-3 and C-2 of the backbone, respectively." [GOC:tair_curators]
synonym: "rhamnogalacturonan II side chain metabolism" EXACT []
is_a: GO:0010396 ! rhamnogalacturonan II metabolic process

[Term]
id: GO:0010420
name: polyprenyldihydroxybenzoate methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3-polyprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-polyprenyl-4-hydroxy-5-methoxybenzoate + H+." [PMID:9628017]
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0010421
name: hydrogen peroxide-mediated programmed cell death
namespace: biological_process
def: "Programmed cell death induced by hydrogen peroxide. Programmed cell death is the cell death resulting from activation of endogenous cellular processes." [GOC:mtg_apoptosis, PMID:16036580]
synonym: "programmed cell death in response to hydrogen peroxide" EXACT []
is_a: GO:0036474 ! cell death in response to hydrogen peroxide
is_a: GO:0097468 ! programmed cell death in response to reactive oxygen species

[Term]
id: GO:0010422
name: regulation of brassinosteroid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of brassinosteroids." [PMID:16857903]
is_a: GO:0090030 ! regulation of steroid hormone biosynthetic process
is_a: GO:1902930 ! regulation of alcohol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016132 ! brassinosteroid biosynthetic process
relationship: regulates GO:0016132 ! brassinosteroid biosynthetic process

[Term]
id: GO:0010423
name: negative regulation of brassinosteroid biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of brassinosteroids." [PMID:16857903]
is_a: GO:0010422 ! regulation of brassinosteroid biosynthetic process
is_a: GO:0090032 ! negative regulation of steroid hormone biosynthetic process
is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016132 ! brassinosteroid biosynthetic process
relationship: negatively_regulates GO:0016132 ! brassinosteroid biosynthetic process

[Term]
id: GO:0010424
name: DNA methylation on cytosine within a CG sequence
namespace: biological_process
def: "The covalent transfer of a methyl group to C-5 or N-4 of a cytosine located within a CG sequence in a DNA molecule." [GOC:dph, GOC:tb, PMID:17239600]
synonym: "cytosine methylation within a CG sequence" EXACT [GOC:dph, GOC:tb]
is_a: GO:0032776 ! DNA methylation on cytosine

[Term]
id: GO:0010425
name: DNA methylation on cytosine within a CNG sequence
namespace: biological_process
def: "The covalent transfer of a methyl group, to C-5 or N-4, of a cytosine located within a CNG sequence in a DNA molecule. N stands for any nucleotide." [GOC:dph, GOC:tb, PMID:17239600]
synonym: "cytosine methylation within a CNG sequence" EXACT [GOC:dph, GOC:tb]
is_a: GO:0032776 ! DNA methylation on cytosine

[Term]
id: GO:0010426
name: DNA methylation on cytosine within a CHH sequence
namespace: biological_process
def: "The covalent transfer of a methyl group, to C-5 or N-4, of a cytosine located within an asymmetric CHH sequence in a DNA molecule. H stands for an adenine, cytosine, or thymine nucleotide." [GOC:dph, GOC:mah, GOC:tb, PMID:15861207, PMID:17239600]
synonym: "cytosine methylation within a CHH sequence" EXACT [GOC:mah]
synonym: "cytosine methylation within a CNN sequence" EXACT [GOC:dph, GOC:tb]
synonym: "DNA methylation on cytosine within a CNN sequence" EXACT [GOC:mah]
is_a: GO:0032776 ! DNA methylation on cytosine

[Term]
id: GO:0010427
name: abscisic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with abscisic acid, plant hormones that regulate aspects of plant growth." [PMID:17347412]
synonym: "ABA binding" RELATED []
synonym: "abscisate binding" RELATED []
is_a: GO:0019840 ! isoprenoid binding
is_a: GO:0033293 ! monocarboxylic acid binding
is_a: GO:0042562 ! hormone binding
is_a: GO:0043178 ! alcohol binding

[Term]
id: GO:0010428
name: methyl-CpNpG binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a methylated cytosine/unspecified/guanine trinucleotide." [PMID:17239600]
is_a: GO:0000166 ! nucleotide binding

[Term]
id: GO:0010429
name: methyl-CpNpN binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a methylated cytosine/unspecified/unspecified trinucleotide." [PMID:17239600]
is_a: GO:0000166 ! nucleotide binding

[Term]
id: GO:0010430
name: fatty acid omega-oxidation
namespace: biological_process
def: "A fatty acid oxidation process in which the methyl group at the end of the fatty acid molecule (the omega carbon) is first oxidized to a hydroxyl group, then to an oxo group, and finally to a carboxyl group. The long chain dicarboxylates derived from omega-oxidation then enter the beta-oxidation pathway for further degradation." [MetaCyc:PWY-2724, PMID:16404574]
xref: MetaCyc:PWY-2724
is_a: GO:0019395 ! fatty acid oxidation

[Term]
id: GO:0010431
name: seed maturation
namespace: biological_process
def: "A process in seed development that occurs after embryogenesis by which a quiescent state is established in a seed. Seed maturation is characterized by storage compound accumulation, acquisition of desiccation tolerance, growth arrest and the entry into a dormancy period of variable length that is broken upon germination." [PMID:16096971]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0021700 ! developmental maturation
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0048609 ! multicellular organismal reproductive process
relationship: part_of GO:0048316 ! seed development

[Term]
id: GO:0010432
name: bract development
namespace: biological_process
def: "The process whose specific outcome is the progression of the bract over time, from its formation to the mature structure. A bract is a leaf, usually different in form from the foliage leaves, subtending a flower or inflorescence." [GOC:tb, PMID:16554366, PO:0009055]
is_a: GO:0048827 ! phyllome development

[Term]
id: GO:0010433
name: bract morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of a bract are generated and organized. A bract is a leaf, usually different in form from the foliage leaves, subtending a flower or inflorescence." [GOC:tb, PMID:16554366, PO:0009055]
is_a: GO:0009887 ! organ morphogenesis
relationship: part_of GO:0010432 ! bract development

[Term]
id: GO:0010434
name: bract formation
namespace: biological_process
def: "The process that gives rise to a bract. This process pertains to the initial formation of a structure from unspecified parts. A bract is a leaf, usually different in form from the foliage leaves, subtending a flower or inflorescence." [GOC:tb, PMID:16554366, PO:0009055]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0010433 ! bract morphogenesis

[Term]
id: GO:0010435
name: 3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 3-oxo-2-(2'-pentenyl)-cyclopentane-1-octanoic acid + coenzyme A = AMP + diphosphate + 3-oxo-2-(2'-pentenyl)-cyclopentane-1-octanoyl-CoA + H+. 3-oxo-2-(2'-pentenyl)-cyclopentane-1-octanoic acid is also known as OPC-8:0." [PMID:16963437]
synonym: "3-oxo-2-(2'-[Z]-pentenyl)cyclopentane-1-octanoate CoA ligase activity" EXACT [MetaCyc:RXN-10695]
synonym: "3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid (OPC-8:0) CoA ligase activity" EXACT []
synonym: "OPC-8:0 CoA ligase activity" EXACT []
xref: EC:6.2.1.-
xref: MetaCyc:RXN-10695
is_a: GO:0016405 ! CoA-ligase activity

[Term]
id: GO:0010436
name: carotenoid dioxygenase activity
namespace: molecular_function
def: "Catalysis of the oxidative cleavage of carotenoids." [PMID:16459333]
synonym: "carotenoid-cleaving dioxygenase" RELATED []
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0010437
name: 9,10 (9', 10')-carotenoid-cleaving dioxygenase activity
namespace: molecular_function
def: "Catalysis of the oxidative cleavage of carotenoids at the (9, 10) and/or (9', 10') double bond." [PMID:16459333]
is_a: GO:0010436 ! carotenoid dioxygenase activity

[Term]
id: GO:0010438
name: cellular response to sulfur starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of sulfur." [PMID:17420480]
is_a: GO:0009267 ! cellular response to starvation

[Term]
id: GO:0010439
name: regulation of glucosinolate biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae." [PMID:17420480]
is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019761 ! glucosinolate biosynthetic process
relationship: regulates GO:0019761 ! glucosinolate biosynthetic process

[Term]
id: GO:0010440
name: stomatal lineage progression
namespace: biological_process
def: "The process in which an unspecialized epidermal cell progresses through a series of divisions that culminate in the production of a stomatal complex." [GOC:expert_db, GOC:tb]
is_a: GO:0048869 ! cellular developmental process
relationship: part_of GO:0010374 ! stomatal complex development

[Term]
id: GO:0010441
name: guard cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of the guard cell over time, from its formation to the mature structure." [GOC:tb]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0010052 ! guard cell differentiation

[Term]
id: GO:0010442
name: guard cell morphogenesis
namespace: biological_process
def: "Generation and organization of the polarized cell that is capable of turgor driven movement." [GOC:expert_db, GOC:tb]
synonym: "guard cell morphogenesis during differentiation" EXACT []
is_a: GO:0000904 ! cell morphogenesis involved in differentiation
is_a: GO:0009886 ! post-embryonic morphogenesis
relationship: part_of GO:0010441 ! guard cell development

[Term]
id: GO:0010443
name: meristemoid mother cell division
namespace: biological_process
def: "The asymmetric cell division by which a meristemoid mother cells (MMC) give rise to a meristemoid and another cell. The other cell may itself become a MMC or may generate an epidermal cell. Any cell that undergoes this type of division is a MMC." [GOC:expert_db, GOC:tb]
synonym: "meristemoid division" RELATED []
is_a: GO:0000911 ! cytokinesis by cell plate formation
relationship: part_of GO:0010440 ! stomatal lineage progression

[Term]
id: GO:0010444
name: guard mother cell differentiation
namespace: biological_process
def: "The process in which a meristemoid acquires the specialized features of a guard mother cell." [GOC:expert_db, GOC:tb]
is_a: GO:0090627 ! plant epidermal cell differentiation
relationship: part_of GO:0010440 ! stomatal lineage progression

[Term]
id: GO:0010445
name: nuclear dicing body
namespace: cellular_component
def: "A small round nuclear body, measuring 0.2-0.8 microns in diameter that is diffusely distributed throughout the nucleoplasm. Several proteins known to be involved in miRNA processing have been localized to these structures. D-bodies are thought to be involved in primary-miRNA processing and/or storage/assembly of miRNA processing complexes." [PMID:17442570]
synonym: "D body" EXACT []
is_a: GO:0016604 ! nuclear body

[Term]
id: GO:0010446
name: response to alkaline pH
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH > 7. pH is a measure of the acidity or basicity of an aqueous solution." [GOC:go_curators, GOC:tb, http://en.wikipedia.org/wiki/PH]
synonym: "response to alkalinity" BROAD []
synonym: "response to basic pH" EXACT []
is_a: GO:0009268 ! response to pH

[Term]
id: GO:0010447
name: response to acidic pH
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution." [GOC:go_curators, GOC:tb, http://en.wikipedia.org/wiki/PH]
comment: This term should be used to annotate instances where a cell or organism is responding to a chemical that is playing the role of an acid (e.g. proton donor) and therefore lowering the pH. If instead you wish to describe a response to a specific acid as a chemical, such as the anion portion of glutamate, please annotate to the appropriate child of GO:0001101 'response to acid chemical'.
synonym: "response to acidity" BROAD []
is_a: GO:0009268 ! response to pH

[Term]
id: GO:0010448
name: vegetative meristem growth
namespace: biological_process
def: "The increase in size or mass of a vegetative meristem, a population of undifferentiated cells in a plant shoot which maintains a continuous balance between the production of stem cells and the incorporation of their derivatives into lateral organ primordia." [GOC:tb, ISBN:0849397928]
is_a: GO:0035266 ! meristem growth
is_a: GO:0080186 ! developmental vegetative growth
relationship: part_of GO:0048367 ! shoot system development

[Term]
id: GO:0010449
name: root meristem growth
namespace: biological_process
def: "The increase in size or mass of a root meristem, a population of undifferentiated cells in a plant root which maintains a continuous balance between the production of stem cells and the incorporation of their derivatives into the growth of the root." [GOC:tb]
is_a: GO:0035266 ! meristem growth
relationship: part_of GO:0048364 ! root development

[Term]
id: GO:0010450
name: inflorescence meristem growth
namespace: biological_process
def: "The increase in size or mass of an inflorescence meristem, a population of undifferentiated cells in a plant shoot which produces small leaves and then floral meristems, which will give rise to flowers." [GOC:tb]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0035266 ! meristem growth
is_a: GO:0044702 ! single organism reproductive process
relationship: part_of GO:0010229 ! inflorescence development

[Term]
id: GO:0010451
name: floral meristem growth
namespace: biological_process
def: "The increase in size or mass of a floral meristem, a population of undifferentiated cells in a plant that gives rise to a flower." [GOC:tb]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0035266 ! meristem growth
is_a: GO:0044702 ! single organism reproductive process
relationship: part_of GO:0009908 ! flower development

[Term]
id: GO:0010452
name: histone H3-K36 methylation
namespace: biological_process
def: "The modification of histone H3 by addition of one or more methyl groups to lysine at position 36 of the histone." [GOC:pr, GOC:tb]
synonym: "histone H3 K36 methylation" EXACT [GOC:tb]
synonym: "histone H3K36me" EXACT [GOC:tb]
synonym: "histone lysine H3 K36 methylation" EXACT [GOC:tb]
is_a: GO:0034968 ! histone lysine methylation

[Term]
id: GO:0010453
name: regulation of cell fate commitment
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [GOC:dph, GOC:tb]
is_a: GO:0045595 ! regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045165 ! cell fate commitment
relationship: regulates GO:0045165 ! cell fate commitment

[Term]
id: GO:0010454
name: negative regulation of cell fate commitment
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [GOC:dph, GOC:tb]
is_a: GO:0010453 ! regulation of cell fate commitment
is_a: GO:0045596 ! negative regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045165 ! cell fate commitment
relationship: negatively_regulates GO:0045165 ! cell fate commitment

[Term]
id: GO:0010455
name: positive regulation of cell fate commitment
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [GOC:dph, GOC:tb]
is_a: GO:0010453 ! regulation of cell fate commitment
is_a: GO:0045597 ! positive regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045165 ! cell fate commitment
relationship: positively_regulates GO:0045165 ! cell fate commitment

[Term]
id: GO:0010456
name: cell proliferation in dorsal spinal cord
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of the dorsal spinal cord cell population." [GOC:dph, GOC:tb]
is_a: GO:0061351 ! neural precursor cell proliferation

[Term]
id: GO:0010457
name: centriole-centriole cohesion
namespace: biological_process
def: "The process in which the two centrioles within a centrosome remain tightly paired." [GOC:dph, GOC:tb]
is_a: GO:0051297 ! centrosome organization

[Term]
id: GO:0010458
name: exit from mitosis
namespace: biological_process
def: "The cell cycle transition where a cell leaves M phase and enters a new G1 phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:tb]
synonym: "mitotic exit" EXACT []
is_a: GO:0044772 ! mitotic cell cycle phase transition
relationship: part_of GO:0007067 ! mitotic nuclear division

[Term]
id: GO:0010459
name: negative regulation of heart rate
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency or rate of heart contraction." [GOC:dph, GOC:tb]
is_a: GO:0002027 ! regulation of heart rate
is_a: GO:0045822 ! negative regulation of heart contraction

[Term]
id: GO:0010460
name: positive regulation of heart rate
namespace: biological_process
def: "Any process that activates or increases the frequency or rate of heart contraction." [GOC:dph, GOC:tb]
is_a: GO:0002027 ! regulation of heart rate
is_a: GO:0045823 ! positive regulation of heart contraction

[Term]
id: GO:0010461
name: light-activated ion channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of an ion by a channel that opens in response to a light stimulus." [GOC:dph, GOC:tb]
is_a: GO:0005216 ! ion channel activity

[Term]
id: GO:0010462
name: regulation of light-activated voltage-gated calcium channel activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of light-activated voltage-gated calcium channel activity." [GOC:dph, GOC:tb]
is_a: GO:0016061 ! regulation of light-activated channel activity
is_a: GO:0050848 ! regulation of calcium-mediated signaling
is_a: GO:1901385 ! regulation of voltage-gated calcium channel activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008086 ! light-activated voltage-gated calcium channel activity
relationship: regulates GO:0008086 ! light-activated voltage-gated calcium channel activity

[Term]
id: GO:0010463
name: mesenchymal cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:dph, GOC:tb]
is_a: GO:0072089 ! stem cell proliferation

[Term]
id: GO:0010464
name: regulation of mesenchymal cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:dph, GOC:tb]
is_a: GO:0072091 ! regulation of stem cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010463 ! mesenchymal cell proliferation
relationship: regulates GO:0010463 ! mesenchymal cell proliferation

[Term]
id: GO:0010465
name: nerve growth factor receptor activity
namespace: molecular_function
def: "Combining with nerve growth factor (NGF), to prevent apoptosis in neurons and promote nerve growth, or to initiate a change in cell activity." [GOC:dph, GOC:tb]
synonym: "beta-nerve growth factor receptor activity" EXACT [PR:000011194]
synonym: "NGF receptor activity" EXACT [PR:000011194]
is_a: GO:0005030 ! neurotrophin receptor activity
relationship: has_part GO:0048406 ! nerve growth factor binding
relationship: part_of GO:0038180 ! nerve growth factor signaling pathway

[Term]
id: GO:0010466
name: negative regulation of peptidase activity
namespace: biological_process
def: "Any process that stops or reduces the rate of peptidase activity, the hydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb]
is_a: GO:0045861 ! negative regulation of proteolysis
is_a: GO:0051346 ! negative regulation of hydrolase activity
is_a: GO:0052547 ! regulation of peptidase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008233 ! peptidase activity
relationship: negatively_regulates GO:0008233 ! peptidase activity

[Term]
id: GO:0010467
name: gene expression
namespace: biological_process
def: "The process in which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
subset: gosubset_prok
xref: Reactome:REACT_100537 "Gene Expression, Xenopus tropicalis"
xref: Reactome:REACT_101147 "Gene Expression, Danio rerio"
xref: Reactome:REACT_101952 "Gene Expression, Sus scrofa"
xref: Reactome:REACT_105649 "Gene Expression, Drosophila melanogaster"
xref: Reactome:REACT_108313 "Gene Expression, Caenorhabditis elegans"
xref: Reactome:REACT_29068 "Gene Expression, Escherichia coli"
xref: Reactome:REACT_34240 "Gene Expression, Staphylococcus aureus N315"
xref: Reactome:REACT_71 "Gene Expression, Homo sapiens"
xref: Reactome:REACT_78136 "Gene Expression, Mus musculus"
xref: Reactome:REACT_78959 "Gene Expression, Taeniopygia guttata"
xref: Reactome:REACT_79662 "Gene Expression, Plasmodium falciparum"
xref: Reactome:REACT_85241 "Gene Expression, Oryza sativa"
xref: Reactome:REACT_85359 "Gene Expression, Gallus gallus"
xref: Reactome:REACT_86357 "Gene Expression, Canis familiaris"
xref: Reactome:REACT_89816 "Gene Expression, Mycobacterium tuberculosis"
xref: Reactome:REACT_91657 "Gene Expression, Arabidopsis thaliana"
xref: Reactome:REACT_91965 "Gene Expression, Rattus norvegicus"
xref: Reactome:REACT_93586 "Gene Expression, Dictyostelium discoideum"
xref: Reactome:REACT_93968 "Gene Expression, Bos taurus"
xref: Reactome:REACT_94814 "Gene Expression, Schizosaccharomyces pombe"
xref: Reactome:REACT_98256 "Gene Expression, Saccharomyces cerevisiae"
xref: Wikipedia:Gene_expression
is_a: GO:0043170 ! macromolecule metabolic process

[Term]
id: GO:0010468
name: regulation of gene expression
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
comment: This class covers any process that regulates the rate of production of a mature gene product, and so includes processes that regulate that rate by regulating the level, stability or availability of intermediates in the process of gene expression.  For example, it covers any process that regulates the level, stability or availability of mRNA for translation and thereby regulates the rate of production of the encoded protein via translation.
subset: gosubset_prok
synonym: "regulation of gene product expression" RELATED [GOC:curators]
synonym: "regulation of protein expression" NARROW [GOC:curators]
xref: Wikipedia:Regulation_of_gene_expression
is_a: GO:0060255 ! regulation of macromolecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010467 ! gene expression
relationship: regulates GO:0010467 ! gene expression

[Term]
id: GO:0010469
name: regulation of receptor activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of receptor activity. Receptor activity is when a molecule combines with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:dph, GOC:tb]
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0065009 ! regulation of molecular function
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004872 ! receptor activity
relationship: regulates GO:0004872 ! receptor activity

[Term]
id: GO:0010470
name: regulation of gastrulation
namespace: biological_process
def: "Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals." [GOC:dph, GOC:tb]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0045995 ! regulation of embryonic development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007369 ! gastrulation
relationship: regulates GO:0007369 ! gastrulation

[Term]
id: GO:0010471
name: GDP-galactose:mannose-1-phosphate guanylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-L-galactose + alpha-D-mannose 1-phosphate = GDP-alpha-D-mannose + alpha-L-galactose-1-phosphate." [MetaCyc:RXN4FS-12, PMID:17485667]
synonym: "GDP-L-galactose phosphorylase activity" BROAD [MetaCyc:AT4G26850-MONOMER]
synonym: "GDP-L-galactose:mannose-1-phosphate guanylyltransferase activity" EXACT [MetaCyc:RXN4FS-12]
xref: MetaCyc:RXN4FS-12
is_a: GO:0008905 ! mannose-phosphate guanylyltransferase activity

[Term]
id: GO:0010472
name: GDP-galactose:glucose-1-phosphate guanylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-L-galactose + alpha-D-glucose 1-phosphate = alpha-L-galactose-1-phosphate + GDP-alpha-D-glucose." [MetaCyc:RXN4FS-13, PMID:17485667]
synonym: "GDP-L-galactose phosphorylase activity" BROAD [MetaCyc:AT4G26850-MONOMER]
synonym: "GDP-L-galactose:glucose-1-phosphate guanylyltransferase activity" EXACT [MetaCyc:RXN4FS-13]
xref: MetaCyc:RXN4FS-13
is_a: GO:0070568 ! guanylyltransferase activity

[Term]
id: GO:0010473
name: GDP-galactose:myoinositol-1-phosphate guanylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-L-galactose + myo-inositol 1-phosphate = alpha-L-galactose-1-phosphate + GDP-myoinositol." [PMID:17485667]
is_a: GO:0070568 ! guanylyltransferase activity

[Term]
id: GO:0010474
name: glucose-1-phosphate guanylyltransferase (GDP) activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP + D-glucose 1-phosphate = phosphate + GDP-glucose." [PMID:17462988]
synonym: "GDP:glucose-1-phosphate guanyltransferase activity" EXACT []
is_a: GO:0070568 ! guanylyltransferase activity

[Term]
id: GO:0010475
name: galactose-1-phosphate guanylyltransferase (GDP) activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP + L-galactose 1-phosphate = phosphate + GDP-galactose." [PMID:17462988]
synonym: "GDP:galactose-1-phosphate guanyltransferase activity" EXACT []
is_a: GO:0070568 ! guanylyltransferase activity

[Term]
id: GO:0010476
name: gibberellin mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of gibberellin stimulus." [PMID:17521411]
synonym: "gibberellin-mediated signalling" EXACT [GOC:mah]
is_a: GO:0009755 ! hormone-mediated signaling pathway
relationship: part_of GO:0071370 ! cellular response to gibberellin stimulus

[Term]
id: GO:0010477
name: response to sulfur dioxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sulfur dioxide (SO2) stimulus." [PMID:17425719]
is_a: GO:0010035 ! response to inorganic substance
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0010478
name: chlororespiration
namespace: biological_process
def: "A respiratory electron flow (from NAD(P)H to plastoquinone (PQ) and O2) involving both a nonphotochemical reduction and re-oxidation of PQ pool." [GOC:mtg_electron_transport, GOC:tb, PMID:17573537]
is_a: GO:0022904 ! respiratory electron transport chain

[Term]
id: GO:0010479
name: stele development
namespace: biological_process
def: "The process whose specific outcome is the progression of the stele over time, from its formation to the mature structure. The stele is the central column of primary vascular tissue in the root and any tissue that it surrounds." [GOC:tb]
is_a: GO:0009888 ! tissue development
relationship: part_of GO:0048364 ! root development

[Term]
id: GO:0010480
name: microsporocyte differentiation
namespace: biological_process
def: "The process aimed at the progression of a microsporocyte cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. A microsporocyte is a diploid (2n) cell that undergoes meiosis and forms four haploid (1n) microspores; also called microspore mother cell and, in seed plants, pollen mother cell." [CL:0000248, PMID:16751349]
synonym: "pollen mother cell differentiation" RELATED []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0048533 ! sporocyte differentiation
relationship: part_of GO:0048653 ! anther development

[Term]
id: GO:0010481
name: epidermal cell division
namespace: biological_process
def: "Any process resulting in the physical partitioning and separation of an epidermal cell, any of the cells making up the epidermis, into daughter cells." [PMID:17450124]
synonym: "hypodermal cell division" RELATED [GOC:kmv, GOC:rk]
is_a: GO:0051301 ! cell division

[Term]
id: GO:0010482
name: regulation of epidermal cell division
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the physical partitioning and separation of an epidermal cell into daughter cells. An epidermal cell is any of the cells that make up the epidermis." [PMID:17450124]
synonym: "regulation of hypodermal cell division" RELATED [GOC:kmv, GOC:rk]
is_a: GO:0051302 ! regulation of cell division
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010481 ! epidermal cell division
relationship: regulates GO:0010481 ! epidermal cell division

[Term]
id: GO:0010483
name: pollen tube reception
namespace: biological_process
def: "Interaction between the pollen tube, part of the male gametophyte, and the ovule, part of the female gametophyte, that results in the arrest of pollen tube growth, rupture of the pollen tube and the release of the sperm cells." [GOC:tb, PMID:17673660]
is_a: GO:0044703 ! multi-organism reproductive process
is_a: GO:0051703 ! intraspecies interaction between organisms
relationship: part_of GO:0009856 ! pollination

[Term]
id: GO:0010484
name: H3 histone acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + histone H3 = CoA + acetyl-histone H3." [EC:2.3.1.48]
is_a: GO:0004402 ! histone acetyltransferase activity
relationship: part_of GO:0043966 ! histone H3 acetylation

[Term]
id: GO:0010485
name: H4 histone acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + histone H4 = CoA + acetyl-histone H4." [EC:2.3.1.48]
is_a: GO:0004402 ! histone acetyltransferase activity
relationship: part_of GO:0043967 ! histone H4 acetylation

[Term]
id: GO:0010486
name: manganese:proton antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Mn2+(in) + H+(out) = Mn2+(out) + H+(in)." [PMID:17559518]
synonym: "manganese:hydrogen antiporter activity" EXACT []
is_a: GO:0005384 ! manganese ion transmembrane transporter activity
is_a: GO:0051139 ! metal ion:proton antiporter activity

[Term]
id: GO:0010487
name: thermospermine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methioninamine + spermidine = S-methyl-5'-thioadenosine + thermospermine + H+." [EC:2.5.1.79, MetaCyc:RXN-11190, PMID:17560575]
xref: EC:2.5.1.79
xref: MetaCyc:RXN-11190
xref: RHEA:30518
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0010488
name: UDP-galactose:N-glycan beta-1,3-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-galactose + N-glycan = galactose-beta-1,3-N-glycan + UDP." [PMID:17630273]
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0010489
name: UDP-4-keto-6-deoxy-glucose-3,5-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-4-keto-6-deoxyglucose = UDP-4-keto-rhamnose." [GOC:tair_curators, PMID:17190829]
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0010490
name: UDP-4-keto-rhamnose-4-keto-reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-4-keto-rhamnose + NADPH = UDP-rhamnose + NADP+." [GOC:tair_curators, PMID:17190829]
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0010491
name: UTP:arabinose-1-phosphate uridylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-L-arabinose 1-phosphate + UTP = UDP-L-arabinose + diphosphate." [PMID:17341835]
is_a: GO:0051748 ! UTP-monosaccharide-1-phosphate uridylyltransferase activity

[Term]
id: GO:0010492
name: maintenance of shoot apical meristem identity
namespace: biological_process
def: "The process in which an organism retains a population of shoot apical meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:dph, GOC:tb, PMID:17461786]
is_a: GO:0010074 ! maintenance of meristem identity

[Term]
id: GO:0010493
name: Lewis a epitope biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a Lewis a epitope, a trisaccharide (Fuc-alpha-(1->4)[Gal-beta-(1->3)]GlcNAc) characteristic of plant protein N-linked oligosaccharides." [PMID:17630273]
synonym: "LE A biosynthetic process" RELATED []
is_a: GO:0033692 ! cellular polysaccharide biosynthetic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process

[Term]
id: GO:0010494
name: cytoplasmic stress granule
namespace: cellular_component
def: "A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress." [GOC:ans, PMID:17284590, PMID:17601829, PMID:17967451, PMID:20368989]
synonym: "cytoplasmic mRNP granule" EXACT []
synonym: "P-body" NARROW []
synonym: "stress granule" EXACT []
xref: Wikipedia:Stress_granule
is_a: GO:0036464 ! cytoplasmic ribonucleoprotein granule

[Term]
id: GO:0010495
name: long-distance posttranscriptional gene silencing
namespace: biological_process
def: "A posttranscriptional gene silencing process in which the silencing signal originates in a tissue separate from the tissue in which the silencing takes place." [GOC:dph, GOC:tb, PMID:11590235, PMID:17785412]
synonym: "long-distance propagation of posttranscriptional gene silencing" EXACT [GOC:dph, GOC:tb]
is_a: GO:0016441 ! posttranscriptional gene silencing

[Term]
id: GO:0010496
name: intercellular transport
namespace: biological_process
def: "The movement of substances between cells." [GOC:dhl]
is_a: GO:0006810 ! transport
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0010497
name: plasmodesmata-mediated intercellular transport
namespace: biological_process
def: "The movement of substances between cells via plasmodesmata. Plasmodesmata is a fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell." [PMID:17601829]
synonym: "plasmodesma-mediated cell-to-cell transport" EXACT []
synonym: "plasmodesma-mediated intercellular transport" EXACT []
synonym: "plasmodesmata-mediated cell-to-cell transport" EXACT []
is_a: GO:0010496 ! intercellular transport

[Term]
id: GO:0010498
name: proteasomal protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:tb]
synonym: "proteasome-mediated protein catabolic process" EXACT []
synonym: "proteasome-mediated protein catabolism" EXACT []
is_a: GO:0030163 ! protein catabolic process
is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process

[Term]
id: GO:0010499
name: proteasomal ubiquitin-independent protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome but do not involve ubiquitin." [GOC:tb]
is_a: GO:0010498 ! proteasomal protein catabolic process

[Term]
id: GO:0010500
name: transmitting tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of the transmitting tract over time, from its formation to the mature structure. The transmitting tissue is the tissue in the style of a carpel through which the pollen tube grows; it connects the stigma and the inside of ovary." [PMID:17855426]
is_a: GO:0048467 ! gynoecium development

[Term]
id: GO:0010501
name: RNA secondary structure unwinding
namespace: biological_process
def: "The process in which a secondary structure of RNA are broken or 'melted'." [PMID:17169986]
synonym: "RNA duplex unwinding" EXACT [GOC:ecd]
is_a: GO:0016070 ! RNA metabolic process

[Term]
id: GO:0010503
name: obsolete negative regulation of cell cycle arrest in response to nitrogen starvation
namespace: biological_process
def: "OBSOLETE Any process that stops, prevents or reduces the frequency or rate of cell cycle arrest in response to nitrogen starvation." [GOC:dph, GOC:tb]
comment: This term was made obsolete because it is superfluous, as only the more specific 'mitotic G1 cell cycle arrest in response to nitrogen starvation' has been observed.
is_obsolete: true

[Term]
id: GO:0010504
name: obsolete regulation of cell cycle arrest in response to nitrogen starvation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of cell cycle arrest in response to nitrogen starvation." [GOC:dph, GOC:tb]
comment: This term was made obsolete because it is superfluous, as only the more specific 'mitotic G1 cell cycle arrest in response to nitrogen starvation' has been observed.
is_obsolete: true

[Term]
id: GO:0010505
name: obsolete positive regulation of cell cycle arrest in response to nitrogen starvation
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency or rate of cell cycle arrest in response to nitrogen starvation." [GOC:dph, GOC:tb]
comment: This term was made obsolete because it is superfluous, as only the more specific 'mitotic G1 cell cycle arrest in response to nitrogen starvation' has been observed.
is_obsolete: true

[Term]
id: GO:0010506
name: regulation of autophagy
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]
is_a: GO:0031329 ! regulation of cellular catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006914 ! autophagy
relationship: regulates GO:0006914 ! autophagy

[Term]
id: GO:0010507
name: negative regulation of autophagy
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]
is_a: GO:0010506 ! regulation of autophagy
is_a: GO:0031330 ! negative regulation of cellular catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006914 ! autophagy
relationship: negatively_regulates GO:0006914 ! autophagy

[Term]
id: GO:0010508
name: positive regulation of autophagy
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]
is_a: GO:0010506 ! regulation of autophagy
is_a: GO:0031331 ! positive regulation of cellular catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006914 ! autophagy
relationship: positively_regulates GO:0006914 ! autophagy

[Term]
id: GO:0010509
name: polyamine homeostasis
namespace: biological_process
def: "Any biological process involved in the maintenance of an internal steady state of a polyamine." [GOC:dph, GOC:rph, GOC:tb, PMID:11161802, PMID:9761731]
is_a: GO:0048878 ! chemical homeostasis

[Term]
id: GO:0010510
name: regulation of acetyl-CoA biosynthetic process from pyruvate
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate." [GOC:dph, GOC:tb]
xref: Reactome:REACT_106689 "Regulation of pyruvate dehydrogenase (PDH) complex, Taeniopygia guttata"
xref: Reactome:REACT_12528 "Regulation of pyruvate dehydrogenase (PDH) complex, Homo sapiens"
xref: Reactome:REACT_30751 "Regulation of pyruvate dehydrogenase (PDH) complex, Danio rerio"
xref: Reactome:REACT_57380 "Regulation of pyruvate dehydrogenase (PDH) complex, Gallus gallus"
xref: Reactome:REACT_84045 "Regulation of pyruvate dehydrogenase (PDH) complex, Bos taurus"
xref: Reactome:REACT_84576 "Regulation of pyruvate dehydrogenase (PDH) complex, Mus musculus"
xref: Reactome:REACT_87328 "Regulation of pyruvate dehydrogenase (PDH) complex, Sus scrofa"
xref: Reactome:REACT_95852 "Regulation of pyruvate dehydrogenase (PDH) complex, Caenorhabditis elegans"
xref: Reactome:REACT_97098 "Regulation of pyruvate dehydrogenase (PDH) complex, Canis familiaris"
xref: Reactome:REACT_97941 "Regulation of pyruvate dehydrogenase (PDH) complex, Rattus norvegicus"
xref: Reactome:REACT_99062 "Regulation of pyruvate dehydrogenase (PDH) complex, Xenopus tropicalis"
is_a: GO:0050812 ! regulation of acyl-CoA biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006086 ! acetyl-CoA biosynthetic process from pyruvate
relationship: regulates GO:0006086 ! acetyl-CoA biosynthetic process from pyruvate

[Term]
id: GO:0010511
name: regulation of phosphatidylinositol biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phosphatidylinositol." [GOC:dph, GOC:tb, GOC:vw]
is_a: GO:0071071 ! regulation of phospholipid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006661 ! phosphatidylinositol biosynthetic process
relationship: regulates GO:0006661 ! phosphatidylinositol biosynthetic process

[Term]
id: GO:0010512
name: negative regulation of phosphatidylinositol biosynthetic process
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phosphatidylinositol." [GOC:dph, GOC:tb, GOC:vw]
is_a: GO:0010511 ! regulation of phosphatidylinositol biosynthetic process
is_a: GO:0071072 ! negative regulation of phospholipid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006661 ! phosphatidylinositol biosynthetic process
relationship: negatively_regulates GO:0006661 ! phosphatidylinositol biosynthetic process

[Term]
id: GO:0010513
name: positive regulation of phosphatidylinositol biosynthetic process
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phosphatidylinositol." [GOC:dph, GOC:tb, GOC:vw]
is_a: GO:0010511 ! regulation of phosphatidylinositol biosynthetic process
is_a: GO:0071073 ! positive regulation of phospholipid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006661 ! phosphatidylinositol biosynthetic process
relationship: positively_regulates GO:0006661 ! phosphatidylinositol biosynthetic process

[Term]
id: GO:0010514
name: induction of conjugation with cellular fusion
namespace: biological_process
def: "The process in which a cell initiates conjugation with cellular fusion. Conjugation with cellular fusion is the process that results in the union of cellular and genetic information from compatible mating types." [GOC:dph, GOC:tb]
is_a: GO:0031139 ! positive regulation of conjugation with cellular fusion

[Term]
id: GO:0010515
name: negative regulation of induction of conjugation with cellular fusion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency or rate of initiation of conjugation with cellular fusion." [GOC:dph, GOC:tb]
is_a: GO:0031138 ! negative regulation of conjugation with cellular fusion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010514 ! induction of conjugation with cellular fusion
relationship: negatively_regulates GO:0010514 ! induction of conjugation with cellular fusion

[Term]
id: GO:0010516
name: negative regulation of cellular response to nitrogen starvation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular response to nitrogen starvation." [GOC:dph, GOC:tb]
is_a: GO:0010648 ! negative regulation of cell communication
is_a: GO:0032108 ! negative regulation of response to nutrient levels
is_a: GO:0080135 ! regulation of cellular response to stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006995 ! cellular response to nitrogen starvation
relationship: negatively_regulates GO:0006995 ! cellular response to nitrogen starvation

[Term]
id: GO:0010517
name: regulation of phospholipase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0060191 ! regulation of lipase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004620 ! phospholipase activity
relationship: regulates GO:0004620 ! phospholipase activity

[Term]
id: GO:0010518
name: positive regulation of phospholipase activity
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010517 ! regulation of phospholipase activity
is_a: GO:0060193 ! positive regulation of lipase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004620 ! phospholipase activity
relationship: positively_regulates GO:0004620 ! phospholipase activity

[Term]
id: GO:0010519
name: negative regulation of phospholipase activity
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010517 ! regulation of phospholipase activity
is_a: GO:0060192 ! negative regulation of lipase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004620 ! phospholipase activity
relationship: negatively_regulates GO:0004620 ! phospholipase activity

[Term]
id: GO:0010520
name: regulation of reciprocal meiotic recombination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb]
is_a: GO:0000018 ! regulation of DNA recombination
is_a: GO:0060631 ! regulation of meiosis I
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007131 ! reciprocal meiotic recombination
relationship: regulates GO:0007131 ! reciprocal meiotic recombination

[Term]
id: GO:0010521
name: telomerase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a telomerase. Telomerase catalyzes the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence." [GOC:dph, GOC:krc, GOC:tb]
is_a: GO:0004857 ! enzyme inhibitor activity
relationship: negatively_regulates GO:0003720 ! telomerase activity
relationship: part_of GO:0051974 ! negative regulation of telomerase activity

[Term]
id: GO:0010522
name: regulation of calcium ion transport into cytosol
namespace: biological_process
def: "Any process that modulates the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components." [GOC:dph, GOC:tb]
is_a: GO:0051924 ! regulation of calcium ion transport
is_a: GO:1903649 ! regulation of cytoplasmic transport
is_a: GO:2000021 ! regulation of ion homeostasis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060402 ! calcium ion transport into cytosol
relationship: regulates GO:0060402 ! calcium ion transport into cytosol

[Term]
id: GO:0010523
name: negative regulation of calcium ion transport into cytosol
namespace: biological_process
def: "Any process that decreases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components." [GOC:dph, GOC:tb]
is_a: GO:0010522 ! regulation of calcium ion transport into cytosol
is_a: GO:0032845 ! negative regulation of homeostatic process
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051926 ! negative regulation of calcium ion transport
is_a: GO:1903650 ! negative regulation of cytoplasmic transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060402 ! calcium ion transport into cytosol
relationship: negatively_regulates GO:0060402 ! calcium ion transport into cytosol

[Term]
id: GO:0010524
name: positive regulation of calcium ion transport into cytosol
namespace: biological_process
def: "Any process that increases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components." [GOC:dph, GOC:tb]
is_a: GO:0010522 ! regulation of calcium ion transport into cytosol
is_a: GO:0032846 ! positive regulation of homeostatic process
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051928 ! positive regulation of calcium ion transport
is_a: GO:1903651 ! positive regulation of cytoplasmic transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060402 ! calcium ion transport into cytosol
relationship: positively_regulates GO:0060402 ! calcium ion transport into cytosol

[Term]
id: GO:0010525
name: regulation of transposition, RNA-mediated
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of RNA-mediated transposition. RNA-mediated transposition is a type of transpositional recombination which occurs via an RNA intermediate." [GOC:dph, GOC:tb]
is_a: GO:0010528 ! regulation of transposition
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032197 ! transposition, RNA-mediated
relationship: regulates GO:0032197 ! transposition, RNA-mediated

[Term]
id: GO:0010526
name: negative regulation of transposition, RNA-mediated
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of RNA-mediated transposition. RNA-mediated transposition is a type of transpositional recombination which occurs via an RNA intermediate." [GOC:dph, GOC:tb]
is_a: GO:0010525 ! regulation of transposition, RNA-mediated
is_a: GO:0010529 ! negative regulation of transposition
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032197 ! transposition, RNA-mediated
relationship: negatively_regulates GO:0032197 ! transposition, RNA-mediated

[Term]
id: GO:0010527
name: positive regulation of transposition, RNA-mediated
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of RNA-mediated transposition. RNA-mediated transposition is a type of transpositional recombination which occurs via an RNA intermediate." [GOC:dph, GOC:tb]
is_a: GO:0010525 ! regulation of transposition, RNA-mediated
is_a: GO:0010530 ! positive regulation of transposition
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032197 ! transposition, RNA-mediated
relationship: positively_regulates GO:0032197 ! transposition, RNA-mediated

[Term]
id: GO:0010528
name: regulation of transposition
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites." [GOC:dph, GOC:tb]
subset: gosubset_prok
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032196 ! transposition
relationship: regulates GO:0032196 ! transposition

[Term]
id: GO:0010529
name: negative regulation of transposition
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites." [GOC:dph, GOC:tb]
is_a: GO:0010528 ! regulation of transposition
is_a: GO:0048523 ! negative regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032196 ! transposition
relationship: negatively_regulates GO:0032196 ! transposition

[Term]
id: GO:0010530
name: positive regulation of transposition
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites." [GOC:dph, GOC:tb]
is_a: GO:0010528 ! regulation of transposition
is_a: GO:0048522 ! positive regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032196 ! transposition
relationship: positively_regulates GO:0032196 ! transposition

[Term]
id: GO:0010531
name: activation of JAK1 kinase activity
namespace: biological_process
def: "The process of introducing a phosphate group to a tyrosine residue of a JAK1 (Janus Activated Kinase 1) protein, thereby activating it." [GOC:dph, GOC:tb, PMID:9135582]
synonym: "activation of JAK1 protein" EXACT [GOC:dph, GOC:tb]
synonym: "tyrosine phosphorylation of JAK1 protein" RELATED [GOC:dph, GOC:tb]
is_a: GO:0042976 ! activation of Janus kinase activity

[Term]
id: GO:0010532
name: regulation of activation of JAK1 kinase activity
namespace: biological_process
def: "Any process that modulates the frequency or rate of activation of JAK1 protein. The activation of JAK1 protein is the process of introducing a phosphate group to a tyrosine residue of a JAK1 (Janus Activated Kinase 1) protein, thereby activating it." [GOC:dph, GOC:tb, PMID:9135582]
synonym: "regulation of activation of JAK1 protein" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of tyrosine phosphorylation of JAK1 protein" RELATED [GOC:dph, GOC:tb]
is_a: GO:0010533 ! regulation of activation of Janus kinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010531 ! activation of JAK1 kinase activity
relationship: regulates GO:0010531 ! activation of JAK1 kinase activity

[Term]
id: GO:0010533
name: regulation of activation of Janus kinase activity
namespace: biological_process
def: "Any process that modulates the frequency or rate of activation of JAK protein. The activation of JAK protein is the process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it." [GOC:dph, GOC:tb, PMID:17190829, PMID:9135582]
synonym: "regulation of activation of JAK protein" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of tyrosine phosphorylation of JAK protein" RELATED [GOC:dph, GOC:tb]
is_a: GO:0045859 ! regulation of protein kinase activity
is_a: GO:0046425 ! regulation of JAK-STAT cascade
is_a: GO:0050730 ! regulation of peptidyl-tyrosine phosphorylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042976 ! activation of Janus kinase activity
relationship: regulates GO:0042976 ! activation of Janus kinase activity

[Term]
id: GO:0010534
name: regulation of activation of JAK2 kinase activity
namespace: biological_process
def: "Any process that modulates the frequency or rate of activation of JAK2 protein. The activation of JAK2 protein is the process of introducing a phosphate group to a tyrosine residue of a JAK2 (Janus Activated Kinase 2) protein, thereby activating it." [GOC:dph, GOC:tb, PMID:9135582]
synonym: "regulation of activation of JAK2 protein" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of tyrosine phosphorylation of JAK2 protein" RELATED [GOC:dph, GOC:tb]
is_a: GO:0010533 ! regulation of activation of Janus kinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042977 ! activation of JAK2 kinase activity
relationship: regulates GO:0042977 ! activation of JAK2 kinase activity

[Term]
id: GO:0010535
name: positive regulation of activation of JAK2 kinase activity
namespace: biological_process
def: "Any process that increase the frequency or rate of activation of JAK2 protein. The activation of JAK2 protein is the process of introducing a phosphate group to a tyrosine residue of a JAK2 (Janus Activated Kinase 2) protein, thereby activating it." [GOC:dph, GOC:tb, PMID:9135582]
synonym: "positive regulation of activation of JAK2 protein" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of tyrosine phosphorylation of JAK2 protein" RELATED [GOC:dph, GOC:tb]
is_a: GO:0010534 ! regulation of activation of JAK2 kinase activity
is_a: GO:0010536 ! positive regulation of activation of Janus kinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042977 ! activation of JAK2 kinase activity
relationship: positively_regulates GO:0042977 ! activation of JAK2 kinase activity

[Term]
id: GO:0010536
name: positive regulation of activation of Janus kinase activity
namespace: biological_process
def: "Any process that increases the frequency or rate of activation of JAK protein. The activation of JAK protein is the process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it." [GOC:dph, GOC:tb, PMID:9135582]
synonym: "positive regulation of activation of JAK protein" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of tyrosine phosphorylation of JAK protein" RELATED [GOC:dph, GOC:tb]
is_a: GO:0010533 ! regulation of activation of Janus kinase activity
is_a: GO:0050731 ! positive regulation of peptidyl-tyrosine phosphorylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042976 ! activation of Janus kinase activity
relationship: positively_regulates GO:0042976 ! activation of Janus kinase activity

[Term]
id: GO:0010537
name: positive regulation of activation of JAK1 kinase activity
namespace: biological_process
def: "Any process that increases the frequency or rate of activation of JAK1 protein. The activation of JAK1 protein is the process of introducing a phosphate group to a tyrosine residue of a JAK1 (Janus Activated Kinase 1) protein, thereby activating it." [GOC:dph, GOC:tb, PMID:9135582]
synonym: "positive regulation of activation of JAK1 protein" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of tyrosine phosphorylation of JAK1 protein" RELATED [GOC:dph, GOC:tb]
is_a: GO:0010532 ! regulation of activation of JAK1 kinase activity
is_a: GO:0010536 ! positive regulation of activation of Janus kinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010531 ! activation of JAK1 kinase activity
relationship: positively_regulates GO:0010531 ! activation of JAK1 kinase activity

[Term]
id: GO:0010538
name: obsolete Hsp27 protein regulator activity
namespace: molecular_function
def: "OBSOLETE. Modulates the activity of the Hsp27 molecular chaperone." [GOC:dph, GOC:tb, PMID:11546764]
comment: This term was made obsolete because it refers to a non-existent molecular function term, 'Hsp27 protein activity'.
synonym: "Hsp27 protein regulator activity" EXACT []
is_obsolete: true
replaced_by: GO:0051008
consider: GO:0006457
consider: GO:0051082
consider: GO:0051787

[Term]
id: GO:0010539
name: obsolete Hsp27 protein inhibitor activity
namespace: molecular_function
def: "OBSOLETE. Stops, prevents or reduces the activity of the Hsp27 molecular chaperone." [GOC:dph, GOC:tb]
comment: This term was made obsolete because it refers to a non-existent molecular function term, 'Hsp27 protein activity'.
synonym: "Hsp27 protein inhibitor activity" EXACT []
is_obsolete: true
replaced_by: GO:0051008
consider: GO:0006457
consider: GO:0051082
consider: GO:0051787

[Term]
id: GO:0010540
name: basipetal auxin transport
namespace: biological_process
def: "The unidirectional movement of auxin from the apex to base of an organ, including the shoot, leaf, primary root, or lateral root." [PMID:10677441]
is_a: GO:0009926 ! auxin polar transport

[Term]
id: GO:0010541
name: acropetal auxin transport
namespace: biological_process
def: "The unidirectional movement of auxin from the base towards the apex of an organ, including the shoot, leaf, primary root, or lateral root." [PMID:10677441]
is_a: GO:0009926 ! auxin polar transport

[Term]
id: GO:0010542
name: nitrate efflux transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of nitrate from the inside of the cell to the outside of the cell across a membrane." [GOC:mah]
is_a: GO:0015112 ! nitrate transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity
is_a: GO:0015562 ! efflux transmembrane transporter activity

[Term]
id: GO:0010543
name: regulation of platelet activation
namespace: biological_process
def: "Any process that modulates the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0030193 ! regulation of blood coagulation
is_a: GO:0050865 ! regulation of cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030168 ! platelet activation
relationship: regulates GO:0030168 ! platelet activation

[Term]
id: GO:0010544
name: negative regulation of platelet activation
namespace: biological_process
def: "Any process that decreases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010543 ! regulation of platelet activation
is_a: GO:0030195 ! negative regulation of blood coagulation
is_a: GO:0050866 ! negative regulation of cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030168 ! platelet activation
relationship: negatively_regulates GO:0030168 ! platelet activation

[Term]
id: GO:0010545
name: obsolete Hsp90 protein regulator activity
namespace: molecular_function
def: "OBSOLETE. Binds to and modulates the activity of the molecular chaperone Hsp90." [GOC:dph, GOC:tb, PMID:11146632]
comment: This term was made obsolete because it refers to a non-existent molecular function term, 'Hsp90 protein activity'.
synonym: "Hsp90 protein regulator activity" EXACT []
is_obsolete: true
replaced_by: GO:0051879
consider: GO:0006457
consider: GO:0051082
consider: GO:0051787

[Term]
id: GO:0010546
name: obsolete Hsp90 protein inhibitor activity
namespace: molecular_function
def: "OBSOLETE. Stops, prevents or reduces the activity of the Hsp90 molecular chaperone." [GOC:dph, GOC:tb, PMID:11146632]
comment: This term was made obsolete because it refers to a non-existent molecular function term, 'Hsp90 protein activity'.
synonym: "Hsp90 protein inhibitor activity" EXACT []
is_obsolete: true
replaced_by: GO:0051879
consider: GO:0006457
consider: GO:0051082
consider: GO:0051787

[Term]
id: GO:0010547
name: thylakoid membrane disassembly
namespace: biological_process
def: "The controlled breakdown of the thylakoid membrane in the context of a normal process." [GOC:dph, GOC:tb, PMID:17416733]
synonym: "thylakoid membrane degradation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010027 ! thylakoid membrane organization
is_a: GO:0030397 ! membrane disassembly

[Term]
id: GO:0010548
name: regulation of thylakoid membrane disassembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of thylakoid membrane disassembly." [GOC:dph, GOC:tb, PMID:17416733]
synonym: "regulation of thylakoid membrane degradation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010549 ! regulation of membrane disassembly
is_a: GO:0033043 ! regulation of organelle organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010547 ! thylakoid membrane disassembly
relationship: regulates GO:0010547 ! thylakoid membrane disassembly

[Term]
id: GO:0010549
name: regulation of membrane disassembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of membrane disassembly." [GOC:dph, GOC:tb]
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030397 ! membrane disassembly
relationship: regulates GO:0030397 ! membrane disassembly

[Term]
id: GO:0010550
name: regulation of PSII associated light-harvesting complex II catabolic process
namespace: biological_process
def: "Any process that modulates the chemical reactions and pathways resulting in the breakdown of one or more components of the light-harvesting complex of photosystem II." [GOC:dph, GOC:tb]
synonym: "regulation of LHCII catabolism" EXACT [GOC:dph, GOC:tb, PMID:17416733]
synonym: "regulation of LHCII degradation" EXACT [PMID:17416733]
is_a: GO:1903362 ! regulation of cellular protein catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010304 ! PSII associated light-harvesting complex II catabolic process
relationship: regulates GO:0010304 ! PSII associated light-harvesting complex II catabolic process

[Term]
id: GO:0010555
name: response to mannitol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus." [PMID:17999646]
synonym: "response to mannitol stimulus" EXACT [GOC:dos]
is_a: GO:0009743 ! response to carbohydrate

[Term]
id: GO:0010556
name: regulation of macromolecule biosynthetic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]
subset: gosubset_prok
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0060255 ! regulation of macromolecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009059 ! macromolecule biosynthetic process
relationship: regulates GO:0009059 ! macromolecule biosynthetic process

[Term]
id: GO:0010557
name: positive regulation of macromolecule biosynthetic process
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009059 ! macromolecule biosynthetic process
relationship: positively_regulates GO:0009059 ! macromolecule biosynthetic process

[Term]
id: GO:0010558
name: negative regulation of macromolecule biosynthetic process
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009059 ! macromolecule biosynthetic process
relationship: negatively_regulates GO:0009059 ! macromolecule biosynthetic process

[Term]
id: GO:0010559
name: regulation of glycoprotein biosynthetic process
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:dph, GOC:tb]
subset: gosubset_prok
is_a: GO:1903018 ! regulation of glycoprotein metabolic process
is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009101 ! glycoprotein biosynthetic process
relationship: regulates GO:0009101 ! glycoprotein biosynthetic process

[Term]
id: GO:0010560
name: positive regulation of glycoprotein biosynthetic process
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:dph, GOC:tb]
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:1903020 ! positive regulation of glycoprotein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009101 ! glycoprotein biosynthetic process
relationship: positively_regulates GO:0009101 ! glycoprotein biosynthetic process

[Term]
id: GO:0010561
name: negative regulation of glycoprotein biosynthetic process
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:dph, GOC:tb]
is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process
is_a: GO:1903019 ! negative regulation of glycoprotein metabolic process
is_a: GO:2000113 ! negative regulation of cellular macromolecule biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009101 ! glycoprotein biosynthetic process
relationship: negatively_regulates GO:0009101 ! glycoprotein biosynthetic process

[Term]
id: GO:0010562
name: positive regulation of phosphorus metabolic process
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:dph, GOC:tb]
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0051174 ! regulation of phosphorus metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006793 ! phosphorus metabolic process
relationship: positively_regulates GO:0006793 ! phosphorus metabolic process

[Term]
id: GO:0010563
name: negative regulation of phosphorus metabolic process
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:dph, GOC:tb]
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0051174 ! regulation of phosphorus metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006793 ! phosphorus metabolic process
relationship: negatively_regulates GO:0006793 ! phosphorus metabolic process

[Term]
id: GO:0010564
name: regulation of cell cycle process
namespace: biological_process
def: "Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb]
is_a: GO:0051726 ! regulation of cell cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0022402 ! cell cycle process
relationship: regulates GO:0022402 ! cell cycle process

[Term]
id: GO:0010565
name: regulation of cellular ketone metabolic process
namespace: biological_process
def: "Any process that modulates the chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:dph, GOC:tb]
is_a: GO:0031323 ! regulation of cellular metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042180 ! cellular ketone metabolic process
relationship: regulates GO:0042180 ! cellular ketone metabolic process

[Term]
id: GO:0010566
name: regulation of ketone biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a ketone, carried out by individual cells." [GOC:dph, GOC:tb]
is_a: GO:0010565 ! regulation of cellular ketone metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042181 ! ketone biosynthetic process
relationship: regulates GO:0042181 ! ketone biosynthetic process

[Term]
id: GO:0010567
name: regulation of ketone catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a ketone, carried out by individual cells." [GOC:dph, GOC:tb]
is_a: GO:0010565 ! regulation of cellular ketone metabolic process
is_a: GO:0031329 ! regulation of cellular catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042182 ! ketone catabolic process
relationship: regulates GO:0042182 ! ketone catabolic process

[Term]
id: GO:0010568
name: regulation of budding cell apical bud growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of growth at the tip of a bud, in a cell that reproduces by budding." [GOC:dph, GOC:jp, GOC:tb, PMID:17417630]
is_a: GO:0007116 ! regulation of cell budding
is_a: GO:0040008 ! regulation of growth
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007118 ! budding cell apical bud growth
relationship: regulates GO:0007118 ! budding cell apical bud growth

[Term]
id: GO:0010569
name: regulation of double-strand break repair via homologous recombination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences." [GOC:dph, GOC:jp, GOC:tb]
is_a: GO:0000018 ! regulation of DNA recombination
is_a: GO:2000779 ! regulation of double-strand break repair
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000724 ! double-strand break repair via homologous recombination
relationship: regulates GO:0000724 ! double-strand break repair via homologous recombination

[Term]
id: GO:0010570
name: regulation of filamentous growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the process in which a multicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape." [GOC:dph, GOC:jp, GOC:tb]
is_a: GO:0040008 ! regulation of growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030447 ! filamentous growth
relationship: regulates GO:0030447 ! filamentous growth

[Term]
id: GO:0010571
name: positive regulation of nuclear cell cycle DNA replication
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle." [GOC:mtg_cell_cycle]
synonym: "positive regulation of DNA replication during S phase" RELATED [GOC:dph, GOC:tb]
synonym: "positive regulation of DNA replication involved in S phase" EXACT []
synonym: "positive regulation of DNA replication involved in S-phase" EXACT []
is_a: GO:0033262 ! regulation of nuclear cell cycle DNA replication
is_a: GO:0090068 ! positive regulation of cell cycle process
is_a: GO:2000105 ! positive regulation of DNA-dependent DNA replication
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0033260 ! nuclear DNA replication
relationship: positively_regulates GO:0033260 ! nuclear DNA replication

[Term]
id: GO:0010572
name: positive regulation of platelet activation
namespace: biological_process
def: "Any process that increases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue." [GOC:dph, GOC:sl, GOC:tb]
is_a: GO:0010543 ! regulation of platelet activation
is_a: GO:0030194 ! positive regulation of blood coagulation
is_a: GO:0050867 ! positive regulation of cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030168 ! platelet activation
relationship: positively_regulates GO:0030168 ! platelet activation

[Term]
id: GO:0010573
name: vascular endothelial growth factor production
namespace: biological_process
def: "The appearance of vascular endothelial growth factor production due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rl]
synonym: "VEGF production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0010574
name: regulation of vascular endothelial growth factor production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of vascular endothelial growth factor." [GOC:rl]
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010573 ! vascular endothelial growth factor production
relationship: regulates GO:0010573 ! vascular endothelial growth factor production

[Term]
id: GO:0010575
name: positive regulation of vascular endothelial growth factor production
namespace: biological_process
def: "Any process that increases or activates the frequency, rate, or extent of production of vascular endothelial growth factor." [GOC:BHF, GOC:rl]
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0010574 ! regulation of vascular endothelial growth factor production
relationship: positively_regulates GO:0010573 ! vascular endothelial growth factor production

[Term]
id: GO:0010578
name: regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of adenylate cyclase (AC) activity that is an integral part of a G-protein coupled receptor signaling pathway." [GOC:dph, GOC:signaling, GOC:tb]
synonym: "regulation of adenylate cyclase activity involved in G-protein signaling pathway" EXACT [GOC:signaling]
synonym: "regulation of adenylate cyclase activity involved in G-protein signalling" EXACT [GOC:mah]
is_a: GO:0045761 ! regulation of adenylate cyclase activity
intersection_of: GO:0045761 ! regulation of adenylate cyclase activity
intersection_of: part_of GO:0007188 ! adenylate cyclase-modulating G-protein coupled receptor signaling pathway
relationship: part_of GO:0007188 ! adenylate cyclase-modulating G-protein coupled receptor signaling pathway

[Term]
id: GO:0010579
name: positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of adenylate cyclase (AC) activity that is an integral part of a G-protein coupled receptor signaling pathway." [GOC:dph, GOC:signaling, GOC:tb]
comment: This term can be used to annotate ligands, receptors and G-proteins that lead to activation of adenylate cyclase activity within a signaling pathway.
synonym: "positive regulation of adenylate cyclase activity by G-protein signaling pathway" RELATED [GOC:signaling]
synonym: "positive regulation of adenylate cyclase activity by G-protein signalling pathway" RELATED [GOC:mah]
is_a: GO:0010578 ! regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
is_a: GO:0045762 ! positive regulation of adenylate cyclase activity
intersection_of: GO:0045762 ! positive regulation of adenylate cyclase activity
intersection_of: part_of GO:0007189 ! adenylate cyclase-activating G-protein coupled receptor signaling pathway
relationship: part_of GO:0007189 ! adenylate cyclase-activating G-protein coupled receptor signaling pathway

[Term]
id: GO:0010581
name: regulation of starch biosynthetic process
namespace: biological_process
def: "An process which modulate the frequency, rate or extent of starch biosynthesis, the chemical reactions and pathways resulting in the formation of starch." [GOC:tb]
is_a: GO:0010962 ! regulation of glucan biosynthetic process
is_a: GO:2000904 ! regulation of starch metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019252 ! starch biosynthetic process
relationship: regulates GO:0019252 ! starch biosynthetic process

[Term]
id: GO:0010582
name: floral meristem determinacy
namespace: biological_process
def: "The process in which a floral meristem becomes determinate (i.e. ceases to produce lateral organs and may or may not terminally differentiate)." [PMID:18441215]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0010022 ! meristem determinacy
is_a: GO:0044702 ! single organism reproductive process
relationship: part_of GO:0009908 ! flower development

[Term]
id: GO:0010583
name: response to cyclopentenone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclopentenone stimulus. Cyclopentenones are oxylipins derived from polyunsaturated fatty acids. They are structurally similar to jasmonic acid, but contain a reactive unsaturated carbonyl structure in the cyclo-ring. Cyclopentenones include phytoprostanes and 12-oxo-phytodienoic acid." [PMID:18334669]
is_a: GO:0014070 ! response to organic cyclic compound

[Term]
id: GO:0010584
name: pollen exine formation
namespace: biological_process
def: "The formation of the pollen exine. The reticulate pollen wall pattern consists of two layers, exine and intine." [GOC:dhl]
is_a: GO:0010208 ! pollen wall assembly

[Term]
id: GO:0010585
name: glutamine secretion
namespace: biological_process
def: "The controlled release of glutamine by a cell." [PMID:15208395]
is_a: GO:0006868 ! glutamine transport
is_a: GO:0032940 ! secretion by cell
is_a: GO:0046717 ! acid secretion

[Term]
id: GO:0010586
name: miRNA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression." [PMID:17993620]
synonym: "microRNA metabolic process" EXACT []
is_a: GO:0034660 ! ncRNA metabolic process

[Term]
id: GO:0010587
name: miRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression." [PMID:17993620]
synonym: "microRNA catabolic process" EXACT []
is_a: GO:0010586 ! miRNA metabolic process
is_a: GO:0034661 ! ncRNA catabolic process

[Term]
id: GO:0010588
name: cotyledon vascular tissue pattern formation
namespace: biological_process
def: "Vascular tissue pattern formation as it occurs in the cotyledon of vascular plants." [PMID:10559439]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0010051 ! xylem and phloem pattern formation
is_a: GO:0044702 ! single organism reproductive process
relationship: part_of GO:0048826 ! cotyledon morphogenesis

[Term]
id: GO:0010589
name: leaf proximal/distal pattern formation
namespace: biological_process
def: "The regionalization process within a leaf by which specific areas of cell differentiation are determined along a proximal/distal axis." [PMID:18398054]
is_a: GO:0009954 ! proximal/distal pattern formation

[Term]
id: GO:0010590
name: regulation of cell separation after cytokinesis
namespace: biological_process
alt_id: GO:1902467
alt_id: GO:2001041
def: "Any process that modulates the rate, frequency or extent of the process of physically separating progeny cells after cytokinesis; this may involve enzymatic digestion of septum or cell wall components." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:19959363, PMID:21246752, PMID:22786806]
synonym: "regulation of cell separation following cytokinesis" RELATED [GOC:dph, GOC:tb]
synonym: "regulation of mitotic cytokinetic cell separation" EXACT []
is_a: GO:0051302 ! regulation of cell division
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000920 ! cell separation after cytokinesis
relationship: regulates GO:0000920 ! cell separation after cytokinesis

[Term]
id: GO:0010591
name: regulation of lamellipodium assembly
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb]
synonym: "regulation of lamellipodium biogenesis" RELATED [GOC:mah]
is_a: GO:0060491 ! regulation of cell projection assembly
is_a: GO:1902743 ! regulation of lamellipodium organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030032 ! lamellipodium assembly
relationship: regulates GO:0030032 ! lamellipodium assembly

[Term]
id: GO:0010592
name: positive regulation of lamellipodium assembly
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb]
synonym: "positive regulation of lamellipodium biogenesis" RELATED [GOC:mah]
is_a: GO:0010591 ! regulation of lamellipodium assembly
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:1902745 ! positive regulation of lamellipodium organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030032 ! lamellipodium assembly
relationship: positively_regulates GO:0030032 ! lamellipodium assembly

[Term]
id: GO:0010593
name: negative regulation of lamellipodium assembly
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb]
synonym: "negative regulation of lamellipodium biogenesis" RELATED [GOC:mah]
is_a: GO:0010591 ! regulation of lamellipodium assembly
is_a: GO:1902744 ! negative regulation of lamellipodium organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030032 ! lamellipodium assembly
relationship: negatively_regulates GO:0030032 ! lamellipodium assembly

[Term]
id: GO:0010594
name: regulation of endothelial cell migration
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010632 ! regulation of epithelial cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043542 ! endothelial cell migration
relationship: regulates GO:0043542 ! endothelial cell migration

[Term]
id: GO:0010595
name: positive regulation of endothelial cell migration
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010594 ! regulation of endothelial cell migration
is_a: GO:0010634 ! positive regulation of epithelial cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043542 ! endothelial cell migration
relationship: positively_regulates GO:0043542 ! endothelial cell migration

[Term]
id: GO:0010596
name: negative regulation of endothelial cell migration
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010594 ! regulation of endothelial cell migration
is_a: GO:0010633 ! negative regulation of epithelial cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043542 ! endothelial cell migration
relationship: negatively_regulates GO:0043542 ! endothelial cell migration

[Term]
id: GO:0010597
name: green leaf volatile biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of volatile molecules emitted from green plants, such as hexenal, hexenol and hexenyl acetate, from linoleic acid or linolenic acid." [PMID:17163881]
is_a: GO:0019372 ! lipoxygenase pathway

[Term]
id: GO:0010598
name: NAD(P)H dehydrogenase complex (plastoquinone)
namespace: cellular_component
def: "Complex that possesses NAD(P)H dehydrogenase (plastoquinone) activity. The complex is one of the components of the electron transport chain. It is involved in electron transport from an unidentified electron donor, possibly NADH, NADPH or ferredoxin(Fd) to the plastoquinone pool." [PMID:15608332]
is_a: GO:0044424 ! intracellular part
is_a: GO:0098796 ! membrane protein complex

[Term]
id: GO:0010599
name: production of lsiRNA involved in RNA interference
namespace: biological_process
def: "Cleavage of double-stranded RNA to form lsiRNA (long small interfering RNA), a class of siRNAs 30 to 40 nt in length. lsiRNAs are induced by pathogen infection or under specific growth conditions." [PMID:18003861]
synonym: "RNA interference, production of lsiRNA" EXACT [GOC:mah]
is_a: GO:0070918 ! production of small RNA involved in gene silencing by RNA
relationship: part_of GO:0016246 ! RNA interference

[Term]
id: GO:0010600
name: regulation of auxin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of auxins, plant hormones that regulate aspects of plant growth." [PMID:18287041]
is_a: GO:0046885 ! regulation of hormone biosynthetic process
is_a: GO:0090354 ! regulation of auxin metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009851 ! auxin biosynthetic process
relationship: regulates GO:0009851 ! auxin biosynthetic process

[Term]
id: GO:0010601
name: positive regulation of auxin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of auxins, plant hormones that regulate aspects of plant growth." [PMID:18287041]
is_a: GO:0010600 ! regulation of auxin biosynthetic process
is_a: GO:0046886 ! positive regulation of hormone biosynthetic process
is_a: GO:0090355 ! positive regulation of auxin metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009851 ! auxin biosynthetic process
relationship: positively_regulates GO:0009851 ! auxin biosynthetic process

[Term]
id: GO:0010602
name: regulation of 1-aminocyclopropane-1-carboxylate metabolic process
namespace: biological_process
def: "Regulation of the chemical reactions and pathways involving 1-aminocyclopropane-1-carboxylate, the anion of 1-aminocyclopropane-1-carboxylic acid, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants." [PMID:18055613]
is_a: GO:0006521 ! regulation of cellular amino acid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0018871 ! 1-aminocyclopropane-1-carboxylate metabolic process
relationship: regulates GO:0018871 ! 1-aminocyclopropane-1-carboxylate metabolic process

[Term]
id: GO:0010603
name: regulation of cytoplasmic mRNA processing body assembly
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body." [GOC:dph, GOC:krc, GOC:tb]
is_a: GO:1902115 ! regulation of organelle assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0033962 ! cytoplasmic mRNA processing body assembly
relationship: regulates GO:0033962 ! cytoplasmic mRNA processing body assembly

[Term]
id: GO:0010604
name: positive regulation of macromolecule metabolic process
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0060255 ! regulation of macromolecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043170 ! macromolecule metabolic process
relationship: positively_regulates GO:0043170 ! macromolecule metabolic process

[Term]
id: GO:0010605
name: negative regulation of macromolecule metabolic process
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0060255 ! regulation of macromolecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043170 ! macromolecule metabolic process
relationship: negatively_regulates GO:0043170 ! macromolecule metabolic process

[Term]
id: GO:0010606
name: positive regulation of cytoplasmic mRNA processing body assembly
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body." [GOC:dph, GOC:krc, GOC:tb]
is_a: GO:0010603 ! regulation of cytoplasmic mRNA processing body assembly
is_a: GO:1902117 ! positive regulation of organelle assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0033962 ! cytoplasmic mRNA processing body assembly
relationship: positively_regulates GO:0033962 ! cytoplasmic mRNA processing body assembly

[Term]
id: GO:0010607
name: negative regulation of cytoplasmic mRNA processing body assembly
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body." [GOC:dph, GOC:krc, GOC:tb]
is_a: GO:0010603 ! regulation of cytoplasmic mRNA processing body assembly
is_a: GO:1902116 ! negative regulation of organelle assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0033962 ! cytoplasmic mRNA processing body assembly
relationship: negatively_regulates GO:0033962 ! cytoplasmic mRNA processing body assembly

[Term]
id: GO:0010608
name: posttranscriptional regulation of gene expression
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript." [GOC:dph, GOC:tb]
is_a: GO:0010468 ! regulation of gene expression

[Term]
id: GO:0010609
name: mRNA localization resulting in posttranscriptional regulation of gene expression
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gene expression after the production of a mRNA transcript by its transport into, or maintainance in, a specific location within the cell." [GOC:dph, GOC:tb]
synonym: "mRNA localisation resulting in posttranscriptional regulation of gene expression" EXACT []
synonym: "posttranscriptional regulation of gene expression by mRNA localisation" EXACT [GOC:mah]
synonym: "posttranscriptional regulation of gene expression by mRNA localization" EXACT []
is_a: GO:0008298 ! intracellular mRNA localization
is_a: GO:0010608 ! posttranscriptional regulation of gene expression

[Term]
id: GO:0010610
name: regulation of mRNA stability involved in response to stress
namespace: biological_process
def: "Any process that modulates the propensity of mRNA molecules to degradation that is part of a change in state or activity of a cell as a result of an exogenous disturbance." [GOC:dph, GOC:tb]
is_a: GO:0043488 ! regulation of mRNA stability
intersection_of: GO:0043488 ! regulation of mRNA stability
intersection_of: part_of GO:0006950 ! response to stress
relationship: part_of GO:0006950 ! response to stress
relationship: part_of GO:0033554 ! cellular response to stress

[Term]
id: GO:0010611
name: regulation of cardiac muscle hypertrophy
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division." [GOC:dph, GOC:tb]
is_a: GO:0014743 ! regulation of muscle hypertrophy
is_a: GO:0043502 ! regulation of muscle adaptation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003300 ! cardiac muscle hypertrophy
relationship: regulates GO:0003300 ! cardiac muscle hypertrophy

[Term]
id: GO:0010612
name: regulation of cardiac muscle adaptation
namespace: biological_process
def: "Any process that modulates the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:dph, GOC:tb]
is_a: GO:0043502 ! regulation of muscle adaptation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0014887 ! cardiac muscle adaptation
relationship: regulates GO:0014887 ! cardiac muscle adaptation

[Term]
id: GO:0010613
name: positive regulation of cardiac muscle hypertrophy
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010611 ! regulation of cardiac muscle hypertrophy
is_a: GO:0014742 ! positive regulation of muscle hypertrophy
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003300 ! cardiac muscle hypertrophy
relationship: positively_regulates GO:0003300 ! cardiac muscle hypertrophy

[Term]
id: GO:0010614
name: negative regulation of cardiac muscle hypertrophy
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010611 ! regulation of cardiac muscle hypertrophy
is_a: GO:0014741 ! negative regulation of muscle hypertrophy
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003300 ! cardiac muscle hypertrophy
relationship: negatively_regulates GO:0003300 ! cardiac muscle hypertrophy

[Term]
id: GO:0010615
name: positive regulation of cardiac muscle adaptation
namespace: biological_process
def: "Any process that increases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010612 ! regulation of cardiac muscle adaptation
is_a: GO:0014744 ! positive regulation of muscle adaptation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0014887 ! cardiac muscle adaptation
relationship: positively_regulates GO:0014887 ! cardiac muscle adaptation

[Term]
id: GO:0010616
name: negative regulation of cardiac muscle adaptation
namespace: biological_process
def: "Any process that decreases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010612 ! regulation of cardiac muscle adaptation
is_a: GO:0014745 ! negative regulation of muscle adaptation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0014887 ! cardiac muscle adaptation
relationship: negatively_regulates GO:0014887 ! cardiac muscle adaptation

[Term]
id: GO:0010617
name: circadian regulation of calcium ion oscillation
namespace: biological_process
def: "Any process that modulates the concentration of cytosolic free calcium ion [Ca2+]cyt with a regularity of approximately 24 hours." [PMID:17982000]
synonym: "circadian regulation of [Ca2+]cyt oscillation" RELATED []
synonym: "circadian regulation of Ca2+ oscillation" RELATED []
synonym: "circadian regulation of cytosolic calcium ion homeostasis" EXACT [GOC:dph, GOC:tb]
synonym: "circadian regulation of cytosolic free calcium ion oscillation" RELATED []
is_a: GO:0007623 ! circadian rhythm
is_a: GO:0051480 ! regulation of cytosolic calcium ion concentration

[Term]
id: GO:0010618
name: aerenchyma formation
namespace: biological_process
def: "The process that gives rise to aerenchyma, parenchyma tissue containing particularly large intercellular spaces of schizogenous or lysigenous origin. This process pertains to the initial formation of a structure from unspecified parts." [PMID:18055613, PO:0005702]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis

[Term]
id: GO:0010619
name: adenylate cyclase-activating glucose-activated G-protein coupled receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of glucose binding to a G-protein coupled receptor, where the pathway proceeds with activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP (cAMP)." [GOC:dph, GOC:signaling, GOC:tb]
synonym: "activation of adenylate cyclase activity by glucose involved in G-protein signaling" RELATED [GOC:dph, GOC:tb]
synonym: "activation of adenylate cyclase activity by glucose-triggered G-protein signaling pathway" RELATED [GOC:signaling]
synonym: "activation of adenylate cyclase activity by glucose-triggered G-protein signalling pathway" RELATED [GOC:mah]
is_a: GO:0007189 ! adenylate cyclase-activating G-protein coupled receptor signaling pathway
relationship: part_of GO:0010255 ! glucose mediated signaling pathway

[Term]
id: GO:0010620
name: negative regulation of transcription by transcription factor catabolism
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves the catabolism of a sequence-specific DNA binding transcription factor by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:bf, GOC:dph, GOC:tb]
is_a: GO:0036369 ! transcription factor catabolic process
is_a: GO:0045892 ! negative regulation of transcription, DNA-templated
intersection_of: GO:0036369 ! transcription factor catabolic process
intersection_of: negatively_regulates GO:0006351 ! transcription, DNA-templated
relationship: negatively_regulates GO:0006351 ! transcription, DNA-templated

[Term]
id: GO:0010621
name: negative regulation of transcription by transcription factor localization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves the localization of a transcription factor." [GOC:dph, GOC:tb]
synonym: "negative regulation of transcription by transcription factor localisation" EXACT [GOC:mah]
is_a: GO:0034613 ! cellular protein localization
is_a: GO:0045892 ! negative regulation of transcription, DNA-templated

[Term]
id: GO:0010622
name: specification of ovule identity
namespace: biological_process
def: "The regionalization process in which the identity of an ovule is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tb]
is_a: GO:0003002 ! regionalization
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
relationship: part_of GO:0048482 ! plant ovule morphogenesis

[Term]
id: GO:0010623
name: developmental programmed cell death
namespace: biological_process
def: "The activation of endogenous cellular processes that result in the death of a cell as part of its development." [GOC:dph, GOC:tb]
is_a: GO:0012501 ! programmed cell death
is_a: GO:0048869 ! cellular developmental process
intersection_of: GO:0012501 ! programmed cell death
intersection_of: part_of GO:0048468 ! cell development
relationship: part_of GO:0048468 ! cell development

[Term]
id: GO:0010624
name: regulation of Schwann cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency or rate of multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system." [GOC:dph, GOC:sl, GOC:tb]
is_a: GO:0060251 ! regulation of glial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0014010 ! Schwann cell proliferation
relationship: regulates GO:0014010 ! Schwann cell proliferation

[Term]
id: GO:0010625
name: positive regulation of Schwann cell proliferation
namespace: biological_process
def: "Any process that increases the frequency or rate of the multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system." [GOC:dph, GOC:sl, GOC:tb]
is_a: GO:0010624 ! regulation of Schwann cell proliferation
is_a: GO:0060252 ! positive regulation of glial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0014010 ! Schwann cell proliferation
relationship: positively_regulates GO:0014010 ! Schwann cell proliferation

[Term]
id: GO:0010626
name: negative regulation of Schwann cell proliferation
namespace: biological_process
def: "Any process that decreases the frequency or extent of the multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system." [GOC:dph, GOC:sl, GOC:tb]
is_a: GO:0010624 ! regulation of Schwann cell proliferation
is_a: GO:0060253 ! negative regulation of glial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0014010 ! Schwann cell proliferation
relationship: negatively_regulates GO:0014010 ! Schwann cell proliferation

[Term]
id: GO:0010628
name: positive regulation of gene expression
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
is_a: GO:0010468 ! regulation of gene expression
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010467 ! gene expression
relationship: positively_regulates GO:0010467 ! gene expression

[Term]
id: GO:0010629
name: negative regulation of gene expression
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
comment: This term covers any process that negatively regulates the rate of production of a mature gene product, and so includes processes that negatively regulate that rate by reducing the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that reduces the level, stability or availability of mRNA for translation and thereby reduces the rate of production of the encoded protein via translation.
is_a: GO:0010468 ! regulation of gene expression
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010467 ! gene expression
relationship: negatively_regulates GO:0010467 ! gene expression

[Term]
id: GO:0010630
name: regulation of transcription, start site selection
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA by a mechanism that selects the start site along that template." [GOC:dph, GOC:tb]
is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process

[Term]
id: GO:0010631
name: epithelial cell migration
namespace: biological_process
def: "The orderly movement of an epithelial cell from one site to another, often during the development of a multicellular organism." [GOC:ascb_2009, GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0001667 ! ameboidal-type cell migration
relationship: part_of GO:0090132 ! epithelium migration

[Term]
id: GO:0010632
name: regulation of epithelial cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of epithelial cell migration." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0030334 ! regulation of cell migration
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010631 ! epithelial cell migration
relationship: regulates GO:0010631 ! epithelial cell migration

[Term]
id: GO:0010633
name: negative regulation of epithelial cell migration
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell migration." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010632 ! regulation of epithelial cell migration
is_a: GO:0030336 ! negative regulation of cell migration
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010631 ! epithelial cell migration
relationship: negatively_regulates GO:0010631 ! epithelial cell migration

[Term]
id: GO:0010634
name: positive regulation of epithelial cell migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of epithelial cell migration." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010632 ! regulation of epithelial cell migration
is_a: GO:0030335 ! positive regulation of cell migration
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010631 ! epithelial cell migration
relationship: positively_regulates GO:0010631 ! epithelial cell migration

[Term]
id: GO:0010635
name: regulation of mitochondrial fusion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment." [GOC:dph, GOC:tb]
is_a: GO:0010821 ! regulation of mitochondrion organization
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008053 ! mitochondrial fusion
relationship: regulates GO:0008053 ! mitochondrial fusion

[Term]
id: GO:0010636
name: positive regulation of mitochondrial fusion
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment." [GOC:dph, GOC:tb]
is_a: GO:0010635 ! regulation of mitochondrial fusion
is_a: GO:0010822 ! positive regulation of mitochondrion organization
is_a: GO:0051094 ! positive regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008053 ! mitochondrial fusion
relationship: positively_regulates GO:0008053 ! mitochondrial fusion

[Term]
id: GO:0010637
name: negative regulation of mitochondrial fusion
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment." [GOC:dph, GOC:tb]
is_a: GO:0010635 ! regulation of mitochondrial fusion
is_a: GO:0010823 ! negative regulation of mitochondrion organization
is_a: GO:0051093 ! negative regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008053 ! mitochondrial fusion
relationship: negatively_regulates GO:0008053 ! mitochondrial fusion

[Term]
id: GO:0010638
name: positive regulation of organelle organization
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb]
synonym: "positive regulation of organelle organisation" EXACT [GOC:mah]
synonym: "positive regulation of organelle organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0033043 ! regulation of organelle organization
is_a: GO:0051130 ! positive regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006996 ! organelle organization
relationship: positively_regulates GO:0006996 ! organelle organization

[Term]
id: GO:0010639
name: negative regulation of organelle organization
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb]
synonym: "negative regulation of organelle organisation" EXACT [GOC:mah]
synonym: "negative regulation of organelle organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0033043 ! regulation of organelle organization
is_a: GO:0051129 ! negative regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006996 ! organelle organization
relationship: negatively_regulates GO:0006996 ! organelle organization

[Term]
id: GO:0010640
name: regulation of platelet-derived growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway." [GOC:dph, GOC:hjd, GOC:tb]
synonym: "regulation of platelet-derived growth factor receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0009966 ! regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048008 ! platelet-derived growth factor receptor signaling pathway
relationship: regulates GO:0048008 ! platelet-derived growth factor receptor signaling pathway

[Term]
id: GO:0010641
name: positive regulation of platelet-derived growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway." [GOC:dph, GOC:hjd, GOC:tb]
synonym: "positive regulation of platelet-derived growth factor receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0010640 ! regulation of platelet-derived growth factor receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048008 ! platelet-derived growth factor receptor signaling pathway
relationship: positively_regulates GO:0048008 ! platelet-derived growth factor receptor signaling pathway

[Term]
id: GO:0010642
name: negative regulation of platelet-derived growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway." [GOC:dph, GOC:hjd, GOC:tb]
synonym: "negative regulation of platelet-derived growth factor receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0010640 ! regulation of platelet-derived growth factor receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048008 ! platelet-derived growth factor receptor signaling pathway
relationship: negatively_regulates GO:0048008 ! platelet-derived growth factor receptor signaling pathway

[Term]
id: GO:0010643
name: cell communication by chemical coupling
namespace: biological_process
def: "The process that mediates signaling interactions between one cell and another cell by the transfer of small, water-soluble molecules or metabolites between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb]
is_a: GO:0007154 ! cell communication

[Term]
id: GO:0010644
name: cell communication by electrical coupling
namespace: biological_process
def: "The process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb]
is_a: GO:0007154 ! cell communication

[Term]
id: GO:0010645
name: regulation of cell communication by chemical coupling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell communication via chemical coupling. Cell communication by chemical coupling is the process that mediates signaling interactions between one cell and another cell by the transfer of small, water-soluble molecules or metabolites between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb]
is_a: GO:0010646 ! regulation of cell communication
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010643 ! cell communication by chemical coupling
relationship: regulates GO:0010643 ! cell communication by chemical coupling

[Term]
id: GO:0010646
name: regulation of cell communication
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb]
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007154 ! cell communication
relationship: regulates GO:0007154 ! cell communication

[Term]
id: GO:0010647
name: positive regulation of cell communication
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb]
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0048522 ! positive regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007154 ! cell communication
relationship: positively_regulates GO:0007154 ! cell communication

[Term]
id: GO:0010648
name: negative regulation of cell communication
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb]
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0048523 ! negative regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007154 ! cell communication
relationship: negatively_regulates GO:0007154 ! cell communication

[Term]
id: GO:0010649
name: regulation of cell communication by electrical coupling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell communication via electrical coupling. Cell communication via electrical coupling is the process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb]
is_a: GO:0010646 ! regulation of cell communication
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010644 ! cell communication by electrical coupling
relationship: regulates GO:0010644 ! cell communication by electrical coupling

[Term]
id: GO:0010650
name: positive regulation of cell communication by electrical coupling
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of cell communication via electrical coupling. Cell communication via electrical coupling is the process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb]
is_a: GO:0010647 ! positive regulation of cell communication
is_a: GO:0010649 ! regulation of cell communication by electrical coupling
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010644 ! cell communication by electrical coupling
relationship: positively_regulates GO:0010644 ! cell communication by electrical coupling

[Term]
id: GO:0010651
name: negative regulation of cell communication by electrical coupling
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of cell communication via electrical coupling. Cell communication via electrical coupling is the process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb]
is_a: GO:0010648 ! negative regulation of cell communication
is_a: GO:0010649 ! regulation of cell communication by electrical coupling
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010644 ! cell communication by electrical coupling
relationship: negatively_regulates GO:0010644 ! cell communication by electrical coupling

[Term]
id: GO:0010652
name: positive regulation of cell communication by chemical coupling
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of cell communication via chemical coupling. Cell communication by chemical coupling is the process that mediates signaling interactions between one cell and another cell by the transfer of small, water-soluble molecules or metabolites between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb]
is_a: GO:0010645 ! regulation of cell communication by chemical coupling
is_a: GO:0010647 ! positive regulation of cell communication
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010643 ! cell communication by chemical coupling
relationship: positively_regulates GO:0010643 ! cell communication by chemical coupling

[Term]
id: GO:0010653
name: negative regulation of cell communication by chemical coupling
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of cell communication via chemical coupling. Cell communication by chemical coupling is the process that mediates signaling interactions between one cell and another cell by the transfer of small, water-soluble molecules or metabolites between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb]
is_a: GO:0010645 ! regulation of cell communication by chemical coupling
is_a: GO:0010648 ! negative regulation of cell communication
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010643 ! cell communication by chemical coupling
relationship: negatively_regulates GO:0010643 ! cell communication by chemical coupling

[Term]
id: GO:0010654
name: apical cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into an apical cell. The apical cell is the upper cell formed after the first division of the zygote." [GOC:dph, GOC:tb]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0009793 ! embryo development ending in seed dormancy

[Term]
id: GO:0010656
name: negative regulation of muscle cell apoptotic process
namespace: biological_process
def: "Any process that decreases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb]
synonym: "negative regulation of muscle cell apoptosis" NARROW []
is_a: GO:0010660 ! regulation of muscle cell apoptotic process
is_a: GO:0043066 ! negative regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010657 ! muscle cell apoptotic process
relationship: negatively_regulates GO:0010657 ! muscle cell apoptotic process

[Term]
id: GO:0010657
name: muscle cell apoptotic process
namespace: biological_process
def: "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a muscle cell and result in its death. A muscle cell is a mature contractile cell, commonly known as a myocyte, that forms one of three kinds of muscle." [CL:0000187, GOC:dph, GOC:mtg_apoptosis, GOC:tb]
synonym: "muscle cell apoptosis" NARROW []
is_a: GO:0006915 ! apoptotic process

[Term]
id: GO:0010658
name: striated muscle cell apoptotic process
namespace: biological_process
def: "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a striated muscle cell and result in its death. Striated muscle cells make up striated muscle fibers which are divided by transverse bands into striations." [CL:0000737, GOC:dph, GOC:mtg_apoptosis, GOC:tb]
synonym: "striated muscle cell apoptosis" NARROW []
is_a: GO:0010657 ! muscle cell apoptotic process

[Term]
id: GO:0010659
name: cardiac muscle cell apoptotic process
namespace: biological_process
def: "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a cardiac muscle cell and result in its death. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction." [CL:0000746, GOC:dph, GOC:mtg_apoptosis, GOC:tb]
synonym: "cardiac muscle cell apoptosis" NARROW []
is_a: GO:0010658 ! striated muscle cell apoptotic process

[Term]
id: GO:0010660
name: regulation of muscle cell apoptotic process
namespace: biological_process
def: "Any process that modulates the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb]
synonym: "regulation of muscle cell apoptosis" NARROW []
is_a: GO:0042981 ! regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010657 ! muscle cell apoptotic process
relationship: regulates GO:0010657 ! muscle cell apoptotic process

[Term]
id: GO:0010661
name: positive regulation of muscle cell apoptotic process
namespace: biological_process
def: "Any process that increases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb]
synonym: "positive regulation of muscle cell apoptosis" NARROW []
is_a: GO:0010660 ! regulation of muscle cell apoptotic process
is_a: GO:0043065 ! positive regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010657 ! muscle cell apoptotic process
relationship: positively_regulates GO:0010657 ! muscle cell apoptotic process

[Term]
id: GO:0010662
name: regulation of striated muscle cell apoptotic process
namespace: biological_process
def: "Any process that modulates the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb]
synonym: "regulation of striated muscle cell apoptosis" NARROW []
is_a: GO:0010660 ! regulation of muscle cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010658 ! striated muscle cell apoptotic process
relationship: regulates GO:0010658 ! striated muscle cell apoptotic process

[Term]
id: GO:0010663
name: positive regulation of striated muscle cell apoptotic process
namespace: biological_process
def: "Any process that increases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb]
synonym: "positive regulation of striated muscle cell apoptosis" NARROW []
is_a: GO:0010661 ! positive regulation of muscle cell apoptotic process
is_a: GO:0010662 ! regulation of striated muscle cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010658 ! striated muscle cell apoptotic process
relationship: positively_regulates GO:0010658 ! striated muscle cell apoptotic process

[Term]
id: GO:0010664
name: negative regulation of striated muscle cell apoptotic process
namespace: biological_process
def: "Any process that increases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death." [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:rl, GOC:tb]
synonym: "down regulation of striated muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb]
synonym: "down-regulation of striated muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb]
synonym: "downregulation of striated muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb]
synonym: "inhibition of striated muscle cell apoptosis" NARROW [GOC:dph, GOC:rl, GOC:tb]
synonym: "negative regulation of striated muscle cell apoptosis" NARROW []
is_a: GO:0010656 ! negative regulation of muscle cell apoptotic process
is_a: GO:0010662 ! regulation of striated muscle cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010658 ! striated muscle cell apoptotic process
relationship: negatively_regulates GO:0010658 ! striated muscle cell apoptotic process

[Term]
id: GO:0010665
name: regulation of cardiac muscle cell apoptotic process
namespace: biological_process
def: "Any process that modulates the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb]
synonym: "regulation of cardiac muscle cell apoptosis" NARROW []
is_a: GO:0010662 ! regulation of striated muscle cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010659 ! cardiac muscle cell apoptotic process
relationship: regulates GO:0010659 ! cardiac muscle cell apoptotic process

[Term]
id: GO:0010666
name: positive regulation of cardiac muscle cell apoptotic process
namespace: biological_process
def: "Any process that increases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb]
synonym: "positive regulation of cardiac muscle cell apoptosis" NARROW []
is_a: GO:0010663 ! positive regulation of striated muscle cell apoptotic process
is_a: GO:0010665 ! regulation of cardiac muscle cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010659 ! cardiac muscle cell apoptotic process
relationship: positively_regulates GO:0010659 ! cardiac muscle cell apoptotic process

[Term]
id: GO:0010667
name: negative regulation of cardiac muscle cell apoptotic process
namespace: biological_process
def: "Any process that decreases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death." [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:rl, GOC:tb]
synonym: "down regulation of cardiac muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb]
synonym: "down-regulation of cardiac muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb]
synonym: "downregulation of cardiac muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb]
synonym: "inhibition of cardiac muscle cell apoptosis" NARROW [GOC:dph, GOC:rl, GOC:tb]
synonym: "negative regulation of cardiac muscle cell apoptosis" NARROW []
is_a: GO:0010664 ! negative regulation of striated muscle cell apoptotic process
is_a: GO:0010665 ! regulation of cardiac muscle cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010659 ! cardiac muscle cell apoptotic process
relationship: negatively_regulates GO:0010659 ! cardiac muscle cell apoptotic process

[Term]
id: GO:0010668
name: ectodermal cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an ectodermal cell. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:dph, GOC:tb]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0007398 ! ectoderm development

[Term]
id: GO:0010669
name: epithelial structure maintenance
namespace: biological_process
def: "A tissue homeostatic process required for the maintenance of epithelial structure." [GOC:dph, GOC:tb]
is_a: GO:0001894 ! tissue homeostasis

[Term]
id: GO:0010670
name: obsolete positive regulation of oxygen and reactive oxygen species metabolic process
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving dioxygen (O2), or any of the reactive oxygen species, e.g. superoxide anions (O2-), hydrogen peroxide (H2O2), and hydroxyl radicals (-OH)." [GOC:BHF, GOC:dph, GOC:tb]
comment: This term was made obsolete because, as part of the GO/ChEBI alignment effort, curators determined that oxygen and reactive oxygen species should not be grouped together.
synonym: "positive regulation of oxygen and reactive oxygen species metabolic process" EXACT []
is_obsolete: true
consider: GO:2000376
consider: GO:2000379

[Term]
id: GO:0010671
name: obsolete negative regulation of oxygen and reactive oxygen species metabolic process
namespace: biological_process
def: "OBSOLETE. Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving dioxygen (O2), or any of the reactive oxygen species, e.g. superoxide anions (O2-), hydrogen peroxide (H2O2), and hydroxyl radicals (-OH)." [GOC:BHF, GOC:dph, GOC:tb]
comment: This term was made obsolete because, as part of the GO/ChEBI alignment effort, curators determined that oxygen and reactive oxygen species should not be grouped together.
synonym: "negative regulation of oxygen and reactive oxygen species metabolic process" EXACT []
is_obsolete: true
consider: GO:2000375
consider: GO:2000378

[Term]
id: GO:0010672
name: regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle
namespace: biological_process
def: "A cell cycle process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as part of the meiotic cell cycle." [GOC:dph, GOC:tb]
synonym: "regulation of transcription from RNA polymerase II promoter, meiotic" EXACT [GOC:mah]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0051037 ! regulation of transcription involved in meiotic cell cycle

[Term]
id: GO:0010673
name: positive regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle
namespace: biological_process
def: "A cell cycle process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as part of the meiotic cell cycle." [GOC:dph, GOC:tb]
synonym: "positive regulation of transcription from RNA polymerase II promoter, meiotic" EXACT [GOC:mah]
is_a: GO:0010672 ! regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
is_a: GO:0051039 ! positive regulation of transcription involved in meiotic cell cycle

[Term]
id: GO:0010674
name: negative regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle
namespace: biological_process
def: "A cell cycle process that decreases the frequency, rate or extent of transcription from an RNA polymerase II as part of the meiotic cell cycle." [GOC:dph, GOC:tb]
synonym: "negative regulation of transcription from RNA polymerase II promoter, meiotic" EXACT [GOC:mah]
is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
is_a: GO:0010672 ! regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle
is_a: GO:0051038 ! negative regulation of transcription involved in meiotic cell cycle

[Term]
id: GO:0010675
name: regulation of cellular carbohydrate metabolic process
namespace: biological_process
def: "Any process that modulates the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:dph, GOC:tb]
is_a: GO:0006109 ! regulation of carbohydrate metabolic process
is_a: GO:0031323 ! regulation of cellular metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044262 ! cellular carbohydrate metabolic process
relationship: regulates GO:0044262 ! cellular carbohydrate metabolic process

[Term]
id: GO:0010676
name: positive regulation of cellular carbohydrate metabolic process
namespace: biological_process
def: "Any process that increases the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:dph, GOC:tb]
is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044262 ! cellular carbohydrate metabolic process
relationship: positively_regulates GO:0044262 ! cellular carbohydrate metabolic process

[Term]
id: GO:0010677
name: negative regulation of cellular carbohydrate metabolic process
namespace: biological_process
def: "Any process that decreases the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:dph, GOC:tb]
is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044262 ! cellular carbohydrate metabolic process
relationship: negatively_regulates GO:0044262 ! cellular carbohydrate metabolic process

[Term]
id: GO:0010678
name: negative regulation of cellular carbohydrate metabolic process by negative regulation of transcription, DNA-templated
namespace: biological_process
def: "Any cellular process that decreases the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates carried out by repression of transcription." [GOC:dph, GOC:tb]
synonym: "negative regulation of cellular carbohydrate metabolic process by negative regulation of transcription, DNA-dependent" EXACT [GOC:txnOH]
synonym: "negative regulation of cellular carbohydrate metabolic process by repression of transcription" EXACT [GOC:bf, GOC:vw]
synonym: "negative regulation of cellular carbohydrate metabolic process by transcriptional repression" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process
is_a: GO:0045892 ! negative regulation of transcription, DNA-templated
intersection_of: GO:0045892 ! negative regulation of transcription, DNA-templated
intersection_of: negatively_regulates GO:0044262 ! cellular carbohydrate metabolic process
relationship: negatively_regulates GO:0044262 ! cellular carbohydrate metabolic process

[Term]
id: GO:0010679
name: cinnamic acid biosynthetic process involved in salicylic acid metabolism
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid, which is then utilized in the metabolism of salicylic acid." [GOC:dph, GOC:tb]
is_a: GO:0009800 ! cinnamic acid biosynthetic process
intersection_of: GO:0009800 ! cinnamic acid biosynthetic process
intersection_of: part_of GO:0009696 ! salicylic acid metabolic process
relationship: part_of GO:0009696 ! salicylic acid metabolic process

[Term]
id: GO:0010680
name: cinnamic acid biosynthetic process involved in coumarin metabolism
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid, which is then utilized in the metabolism of coumarin." [GOC:dph, GOC:tb]
is_a: GO:0009800 ! cinnamic acid biosynthetic process
intersection_of: GO:0009800 ! cinnamic acid biosynthetic process
intersection_of: part_of GO:0009804 ! coumarin metabolic process
relationship: part_of GO:0009804 ! coumarin metabolic process

[Term]
id: GO:0010681
name: cinnamic acid biosynthetic process involved in stilbene metabolism
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid, which is then utilized in the metabolism of stilbene." [GOC:dph, GOC:tb]
is_a: GO:0009800 ! cinnamic acid biosynthetic process
intersection_of: GO:0009800 ! cinnamic acid biosynthetic process
intersection_of: part_of GO:0009810 ! stilbene metabolic process
relationship: part_of GO:0009810 ! stilbene metabolic process

[Term]
id: GO:0010682
name: cinnamic acid biosynthetic process involved in flavonoid metabolism
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid, which is then utilized in the metabolism of flavonoids." [GOC:dph, GOC:tb]
is_a: GO:0009800 ! cinnamic acid biosynthetic process
intersection_of: GO:0009800 ! cinnamic acid biosynthetic process
intersection_of: part_of GO:0009812 ! flavonoid metabolic process
relationship: part_of GO:0009812 ! flavonoid metabolic process

[Term]
id: GO:0010683
name: tricyclic triterpenoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tricyclic triterpenoid compounds, terpenoids with six isoprene units and 3 rings." [GOC:tair_curators]
synonym: "tricyclic triterpenoid metabolism" EXACT [GOC:tair_curators]
is_a: GO:0006722 ! triterpenoid metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process

[Term]
id: GO:0010684
name: tricyclic triterpenoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tricyclic triterpenoid compounds, terpenoids with six isoprene units and 3 rings." [GOC:tair_curators]
synonym: "tricyclic triterpenoid catabolism" EXACT [GOC:tair_curators]
is_a: GO:0010683 ! tricyclic triterpenoid metabolic process
is_a: GO:0016105 ! triterpenoid catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process

[Term]
id: GO:0010685
name: tetracyclic triterpenoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tetracyclic triterpenoid compounds, terpenoids with six isoprene units and 4 carbon rings." [GOC:tair_curators]
synonym: "tetracyclic triterpenoid metabolism" EXACT [GOC:tair_curators]
is_a: GO:0006722 ! triterpenoid metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process

[Term]
id: GO:0010686
name: tetracyclic triterpenoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tetracyclic triterpenoid compounds, terpenoids with six isoprene units and 4 carbon rings." [GOC:tair_curators]
synonym: "tetracyclic triterpenoid biosynthesis" EXACT [GOC:tair_curators]
is_a: GO:0010685 ! tetracyclic triterpenoid metabolic process
is_a: GO:0016104 ! triterpenoid biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process

[Term]
id: GO:0010688
name: negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes by RNA polymerase II, originating at an RNA polymerase II promoter." [GOC:dph, GOC:tb, GOC:txnOH]
is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
is_a: GO:0060962 ! regulation of ribosomal protein gene transcription from RNA polymerase II promoter

[Term]
id: GO:0010689
name: negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to chemical stimulus
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes by RNA polymerase II, originating at an RNA polymerase II promoter, as a result of a chemical stimulus." [GOC:dph, GOC:tb, GOC:txnOH]
is_a: GO:0010688 ! negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter
relationship: part_of GO:0042221 ! response to chemical

[Term]
id: GO:0010690
name: negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to stress
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes by RNA polymerase II, originating at an RNA polymerase II promoter, as a result of a disturbance in organismal or cellular homeostasis." [GOC:dph, GOC:tb, GOC:txnOH]
is_a: GO:0010688 ! negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter
is_a: GO:0033554 ! cellular response to stress

[Term]
id: GO:0010691
name: negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to nutrient levels
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes by RNA polymerase II, originating at an RNA polymerase II promoter, as a result of a stimulus reflecting the presence, absence, or concentration of nutrients." [GOC:dph, GOC:tb, GOC:txnOH]
is_a: GO:0010688 ! negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter
is_a: GO:0031669 ! cellular response to nutrient levels

[Term]
id: GO:0010692
name: regulation of alkaline phosphatase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." [GOC:dph, GOC:tb]
is_a: GO:0010921 ! regulation of phosphatase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004035 ! alkaline phosphatase activity
relationship: regulates GO:0004035 ! alkaline phosphatase activity

[Term]
id: GO:0010693
name: negative regulation of alkaline phosphatase activity
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010692 ! regulation of alkaline phosphatase activity
is_a: GO:0010923 ! negative regulation of phosphatase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004035 ! alkaline phosphatase activity
relationship: negatively_regulates GO:0004035 ! alkaline phosphatase activity

[Term]
id: GO:0010694
name: positive regulation of alkaline phosphatase activity
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." [GOC:dph, GOC:tb]
is_a: GO:0010692 ! regulation of alkaline phosphatase activity
is_a: GO:0010922 ! positive regulation of phosphatase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004035 ! alkaline phosphatase activity
relationship: positively_regulates GO:0004035 ! alkaline phosphatase activity

[Term]
id: GO:0010695
name: regulation of spindle pole body separation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the process involving the release of duplicated spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane." [GOC:dph, GOC:tb, PMID:16792804, PMID:18500339]
synonym: "regulation of SPB separation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0070507 ! regulation of microtubule cytoskeleton organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000073 ! spindle pole body separation
relationship: regulates GO:0000073 ! spindle pole body separation

[Term]
id: GO:0010696
name: positive regulation of spindle pole body separation
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the process involving the release of duplicated spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane." [GOC:dph, GOC:tb, PMID:16792804, PMID:18500339]
synonym: "positive regulation of SPB separation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010695 ! regulation of spindle pole body separation
is_a: GO:0051495 ! positive regulation of cytoskeleton organization
is_a: GO:0090068 ! positive regulation of cell cycle process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000073 ! spindle pole body separation
relationship: positively_regulates GO:0000073 ! spindle pole body separation

[Term]
id: GO:0010697
name: negative regulation of spindle pole body separation
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the process involving the release of duplicated spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane." [GOC:dph, GOC:tb, PMID:16792804, PMID:18500339]
synonym: "negative regulation of SPB separation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010695 ! regulation of spindle pole body separation
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0051494 ! negative regulation of cytoskeleton organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000073 ! spindle pole body separation
relationship: negatively_regulates GO:0000073 ! spindle pole body separation

[Term]
id: GO:0010698
name: acetyltransferase activator activity
namespace: molecular_function
def: "Binds to and increases the activity of an acetyltransferase, an enzyme which catalyzes the transfer of an acetyl group to an acceptor molecule." [GOC:dph, GOC:jp, GOC:tb, PMID:18690240]
synonym: "acetyltransferase stimulator activity" EXACT [GOC:dph, GOC:jp, GOC:tb]
is_a: GO:0008047 ! enzyme activator activity
relationship: positively_regulates GO:0016407 ! acetyltransferase activity

[Term]
id: GO:0010699
name: cell-cell signaling involved in quorum sensing
namespace: biological_process
def: "The cell-cell signaling process in which single-celled organisms monitor population density by detecting the concentration of small diffusible signal molecules." [GOC:dph, GOC:tb]
synonym: "cell-cell signalling involved in quorum sensing" EXACT []
is_a: GO:0007267 ! cell-cell signaling
intersection_of: GO:0007267 ! cell-cell signaling
intersection_of: part_of GO:0009372 ! quorum sensing
relationship: part_of GO:0009372 ! quorum sensing

[Term]
id: GO:0010700
name: negative regulation of norepinephrine secretion
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the regulated release of norepinephrine." [GOC:dph, GOC:tb]
is_a: GO:0014061 ! regulation of norepinephrine secretion
is_a: GO:0033604 ! negative regulation of catecholamine secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048243 ! norepinephrine secretion
relationship: negatively_regulates GO:0048243 ! norepinephrine secretion

[Term]
id: GO:0010701
name: positive regulation of norepinephrine secretion
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the regulated release of norepinephrine." [GOC:dph, GOC:tb]
is_a: GO:0014061 ! regulation of norepinephrine secretion
is_a: GO:0033605 ! positive regulation of catecholamine secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048243 ! norepinephrine secretion
relationship: positively_regulates GO:0048243 ! norepinephrine secretion

[Term]
id: GO:0010702
name: obsolete regulation of histolysis
namespace: biological_process
def: "OBSOLETE. Any process that modulates the rate, frequency or extent of the breakdown of tissues; usually, if not always, accompanied by cell death." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]
comment: This term was made obsolete because it refers to a phenotype. When death of a cell or tissue is a result of a true biological process, this should be captured using 'programmed cell death' or one of its descendants.
is_obsolete: true
consider: GO:0008219
consider: GO:0012501

[Term]
id: GO:0010703
name: obsolete negative regulation of histolysis
namespace: biological_process
def: "OBSOLETE. Any process that decreases the rate, frequency or extent of the breakdown of tissues; usually, if not always, accompanied by cell death." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]
comment: This term was made obsolete because it refers to a phenotype. When death of a cell or tissue is a result of a true biological process, this should be captured using 'programmed cell death' or one of its descendants.
synonym: "down regulation of histolysis" EXACT [GOC:dph, GOC:rl, GOC:tb]
synonym: "down-regulation of histolysis" EXACT [GOC:dph, GOC:rl, GOC:tb]
synonym: "downregulation of histolysis" EXACT [GOC:dph, GOC:rl, GOC:tb]
synonym: "inhibition of histolysis" NARROW [GOC:dph, GOC:rl, GOC:tb]
is_obsolete: true
consider: GO:0008219
consider: GO:0012501

[Term]
id: GO:0010704
name: meiotic DNA double-strand break processing involved in meiotic gene conversion
namespace: biological_process
def: "The cell cycle process in which the 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang resulting in the transfer of genetic information from one helix to another." [GOC:dph, GOC:tb]
is_a: GO:0000706 ! meiotic DNA double-strand break processing
intersection_of: GO:0000706 ! meiotic DNA double-strand break processing
intersection_of: part_of GO:0006311 ! meiotic gene conversion
relationship: part_of GO:0006311 ! meiotic gene conversion

[Term]
id: GO:0010705
name: meiotic DNA double-strand break processing involved in reciprocal meiotic recombination
namespace: biological_process
def: "The cell cycle process in which the 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang occurs resulting in double strand break formation and repair through a double Holliday junction intermediate." [GOC:dph, GOC:tb]
is_a: GO:0000706 ! meiotic DNA double-strand break processing
intersection_of: GO:0000706 ! meiotic DNA double-strand break processing
intersection_of: part_of GO:0007131 ! reciprocal meiotic recombination
relationship: part_of GO:0007131 ! reciprocal meiotic recombination

[Term]
id: GO:0010706
name: ganglioside biosynthetic process via lactosylceramide
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of gangliosides that begins with the formation of lactosylceramides, Gal-beta-(1->4)-Glc-beta-(1->1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group." [GOC:bf, GOC:dph, GOC:tb]
synonym: "biosynthesis of lactosylceramide precursor to ganglioside" RELATED [GOC:bf, GOC:dph, GOC:tb]
synonym: "ganglioside biosynthesis via lactosylceramide biosynthesis" EXACT [GOC:bf]
synonym: "lactosylceramide biosynthesis leading to ganglioside" RELATED [GOC:dph, GOC:tb]
synonym: "lactosylceramide biosynthetic process leading to ganglioside" RELATED [GOC:dph, GOC:tb]
is_a: GO:0001574 ! ganglioside biosynthetic process
is_a: GO:0046478 ! lactosylceramide metabolic process

[Term]
id: GO:0010707
name: globoside biosynthetic process via lactosylceramide
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of globosides that begins with the formation of lactosylceramides, Gal-beta-(1->4)-Glc-beta-(1->1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group." [GOC:bf, GOC:dph, GOC:tb]
synonym: "biosynthesis of lactosylceramide precursor to globoside" RELATED [GOC:bf, GOC:dph, GOC:tb]
synonym: "globoside biosynthesis via lactosylceramide biosynthesis" EXACT [GOC:bf]
synonym: "lactosylceramide biosynthesis leading to globoside" RELATED [GOC:dph, GOC:tb]
synonym: "lactosylceramide biosynthetic process leading to globoside" RELATED [GOC:dph, GOC:tb]
is_a: GO:0001576 ! globoside biosynthetic process
is_a: GO:0046478 ! lactosylceramide metabolic process

[Term]
id: GO:0010708
name: heteroduplex formation involved in gene conversion at mating-type locus
namespace: biological_process
def: "The formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules resulting in the conversion of the mating-type locus from one allele to another." [GOC:dph, GOC:tb]
is_a: GO:0022414 ! reproductive process
is_a: GO:0030491 ! heteroduplex formation
intersection_of: GO:0030491 ! heteroduplex formation
intersection_of: part_of GO:0007534 ! gene conversion at mating-type locus
relationship: part_of GO:0007534 ! gene conversion at mating-type locus

[Term]
id: GO:0010709
name: heteroduplex formation involved in double-strand break repair via synthesis-dependent strand annealing
namespace: biological_process
def: "The formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules resulting in the error-free repair of a double-strand break without the exchange of adjacent sequences." [GOC:dph, GOC:tb]
is_a: GO:0030491 ! heteroduplex formation
intersection_of: GO:0030491 ! heteroduplex formation
intersection_of: part_of GO:0045003 ! double-strand break repair via synthesis-dependent strand annealing
relationship: part_of GO:0045003 ! double-strand break repair via synthesis-dependent strand annealing

[Term]
id: GO:0010710
name: regulation of collagen catabolic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "regulation of collagen breakdown" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of collagen catabolism" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of collagen degradation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0009894 ! regulation of catabolic process
is_a: GO:0010712 ! regulation of collagen metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030574 ! collagen catabolic process
relationship: regulates GO:0030574 ! collagen catabolic process

[Term]
id: GO:0010711
name: negative regulation of collagen catabolic process
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "down regulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb]
synonym: "down-regulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb]
synonym: "downregulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb]
synonym: "inhibition of collagen catabolic process" NARROW [GOC:dph, GOC:tb]
synonym: "negative regulation of collagen breakdown" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of collagen catabolism" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of collagen degradation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0010710 ! regulation of collagen catabolic process
is_a: GO:0010713 ! negative regulation of collagen metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030574 ! collagen catabolic process
relationship: negatively_regulates GO:0030574 ! collagen catabolic process

[Term]
id: GO:0010712
name: regulation of collagen metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:dph, GOC:tb]
synonym: "regulation of collagen metabolism" EXACT [GOC:dph, GOC:tb]
is_a: GO:0044246 ! regulation of multicellular organismal metabolic process
is_a: GO:0060255 ! regulation of macromolecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032963 ! collagen metabolic process
relationship: regulates GO:0032963 ! collagen metabolic process

[Term]
id: GO:0010713
name: negative regulation of collagen metabolic process
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:dph, GOC:tb]
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0010712 ! regulation of collagen metabolic process
is_a: GO:0044252 ! negative regulation of multicellular organismal metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032963 ! collagen metabolic process
relationship: negatively_regulates GO:0032963 ! collagen metabolic process

[Term]
id: GO:0010714
name: positive regulation of collagen metabolic process
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:dph, GOC:tb]
synonym: "positive regulation of collagen metabolism" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0010712 ! regulation of collagen metabolic process
is_a: GO:0044253 ! positive regulation of multicellular organismal metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032963 ! collagen metabolic process
relationship: positively_regulates GO:0032963 ! collagen metabolic process

[Term]
id: GO:0010715
name: regulation of extracellular matrix disassembly
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "regulation of extracellular matrix breakdown" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of extracellular matrix degradation" EXACT [GOC:dph, GOC:tb]
is_a: GO:1903053 ! regulation of extracellular matrix organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0022617 ! extracellular matrix disassembly
relationship: regulates GO:0022617 ! extracellular matrix disassembly

[Term]
id: GO:0010716
name: negative regulation of extracellular matrix disassembly
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "down regulation of extracellular matrix disassembly" EXACT [GOC:dph, GOC:tb]
synonym: "down-regulation of extracellular matrix disassembly" EXACT [GOC:dph, GOC:tb]
synonym: "downregulation of extracellular matrix disassembly" EXACT [GOC:dph, GOC:tb]
synonym: "inhibition of extracellular matrix disassembly" NARROW [GOC:dph, GOC:tb]
synonym: "negative regulation of extracellular matrix breakdown" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of extracellular matrix degradation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010715 ! regulation of extracellular matrix disassembly
is_a: GO:1903054 ! negative regulation of extracellular matrix organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0022617 ! extracellular matrix disassembly
relationship: negatively_regulates GO:0022617 ! extracellular matrix disassembly

[Term]
id: GO:0010717
name: regulation of epithelial to mesenchymal transition
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation
is_a: GO:2000026 ! regulation of multicellular organismal development
is_a: GO:2000736 ! regulation of stem cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001837 ! epithelial to mesenchymal transition
relationship: regulates GO:0001837 ! epithelial to mesenchymal transition

[Term]
id: GO:0010718
name: positive regulation of epithelial to mesenchymal transition
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010717 ! regulation of epithelial to mesenchymal transition
is_a: GO:0010770 ! positive regulation of cell morphogenesis involved in differentiation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000738 ! positive regulation of stem cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001837 ! epithelial to mesenchymal transition
relationship: positively_regulates GO:0001837 ! epithelial to mesenchymal transition

[Term]
id: GO:0010719
name: negative regulation of epithelial to mesenchymal transition
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010717 ! regulation of epithelial to mesenchymal transition
is_a: GO:0010771 ! negative regulation of cell morphogenesis involved in differentiation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000737 ! negative regulation of stem cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001837 ! epithelial to mesenchymal transition
relationship: negatively_regulates GO:0001837 ! epithelial to mesenchymal transition

[Term]
id: GO:0010720
name: positive regulation of cell development
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0060284 ! regulation of cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048468 ! cell development
relationship: positively_regulates GO:0048468 ! cell development

[Term]
id: GO:0010721
name: negative regulation of cell development
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0060284 ! regulation of cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048468 ! cell development
relationship: negatively_regulates GO:0048468 ! cell development

[Term]
id: GO:0010722
name: regulation of ferrochelatase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ferrochelatase activity; catalysis of the reaction: protoporphyrin + Fe2+ = protoheme + 2 H+." [GOC:dph, GOC:tb]
is_a: GO:0051339 ! regulation of lyase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004325 ! ferrochelatase activity
relationship: regulates GO:0004325 ! ferrochelatase activity

[Term]
id: GO:0010723
name: positive regulation of transcription from RNA polymerase II promoter in response to iron
namespace: biological_process
def: "Any process that increases the rate of transcription from an RNA polymerase II promoter in response to an iron stimulus." [GOC:dph, GOC:tb]
is_a: GO:0034395 ! regulation of transcription from RNA polymerase II promoter in response to iron
is_a: GO:1901522 ! positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus

[Term]
id: GO:0010724
name: regulation of definitive erythrocyte differentiation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of definitive erythrocyte differentiation. Definitive erythrocyte differentiation occurs as part of the process of definitive hemopoiesis." [GOC:add, GOC:dph, GOC:tb]
synonym: "regulation of definitive erythropoiesis" EXACT [GOC:add, GOC:dph, GOC:tb]
synonym: "regulation of definitive RBC differentiation" EXACT [CL:0000232]
synonym: "regulation of definitive red blood cell differentiation" EXACT [CL:0000232]
is_a: GO:0045646 ! regulation of erythrocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060318 ! definitive erythrocyte differentiation
relationship: regulates GO:0060318 ! definitive erythrocyte differentiation

[Term]
id: GO:0010725
name: regulation of primitive erythrocyte differentiation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of primitive erythrocyte differentiation. Primitive erythrocyte differentiation occurs as part of the process of primitive hemopoiesis." [GOC:add, GOC:dph, GOC:tb]
synonym: "regulation of primitive erythropoeisis" EXACT [GOC:add, GOC:dph, GOC:tb]
synonym: "regulation of primitive RBC differentiation" EXACT [CL:0000232]
synonym: "regulation of primitive red blood cell differentiation" EXACT [CL:0000232]
is_a: GO:0045646 ! regulation of erythrocyte differentiation
is_a: GO:0045995 ! regulation of embryonic development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060319 ! primitive erythrocyte differentiation
relationship: regulates GO:0060319 ! primitive erythrocyte differentiation

[Term]
id: GO:0010726
name: positive regulation of hydrogen peroxide metabolic process
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide." [GOC:dph, GOC:hjd, GOC:tb]
synonym: "positive regulation of hydrogen peroxide metabolism" EXACT [GOC:dph, GOC:hjd, GOC:tb]
is_a: GO:0010310 ! regulation of hydrogen peroxide metabolic process
is_a: GO:2000379 ! positive regulation of reactive oxygen species metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042743 ! hydrogen peroxide metabolic process
relationship: positively_regulates GO:0042743 ! hydrogen peroxide metabolic process

[Term]
id: GO:0010727
name: negative regulation of hydrogen peroxide metabolic process
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide." [GOC:dph, GOC:hjd, GOC:tb]
synonym: "negative regulation of hydrogen peroxide metabolism" EXACT [GOC:dph, GOC:hjd, GOC:tb]
is_a: GO:0010310 ! regulation of hydrogen peroxide metabolic process
is_a: GO:2000378 ! negative regulation of reactive oxygen species metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042743 ! hydrogen peroxide metabolic process
relationship: negatively_regulates GO:0042743 ! hydrogen peroxide metabolic process

[Term]
id: GO:0010728
name: regulation of hydrogen peroxide biosynthetic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA." [GOC:dph, GOC:hjd, GOC:tb]
synonym: "regulation of hydrogen peroxide biosynthesis" EXACT [GOC:dph, GOC:hjd, GOC:tb]
is_a: GO:0010310 ! regulation of hydrogen peroxide metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:1903426 ! regulation of reactive oxygen species biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050665 ! hydrogen peroxide biosynthetic process
relationship: regulates GO:0050665 ! hydrogen peroxide biosynthetic process

[Term]
id: GO:0010729
name: positive regulation of hydrogen peroxide biosynthetic process
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA." [GOC:dph, GOC:hjd, GOC:tb]
synonym: "positive regulation of hydrogen peroxide biosynthesis" EXACT [GOC:dph, GOC:hjd, GOC:tb]
is_a: GO:0010726 ! positive regulation of hydrogen peroxide metabolic process
is_a: GO:0010728 ! regulation of hydrogen peroxide biosynthetic process
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:1903428 ! positive regulation of reactive oxygen species biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0050665 ! hydrogen peroxide biosynthetic process
relationship: positively_regulates GO:0050665 ! hydrogen peroxide biosynthetic process

[Term]
id: GO:0010730
name: negative regulation of hydrogen peroxide biosynthetic process
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA." [GOC:dph, GOC:hjd, GOC:tb]
synonym: "negative regulation of hydrogen peroxide biosynthesis" EXACT [GOC:dph, GOC:hjd, GOC:tb]
is_a: GO:0010727 ! negative regulation of hydrogen peroxide metabolic process
is_a: GO:0010728 ! regulation of hydrogen peroxide biosynthetic process
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:1903427 ! negative regulation of reactive oxygen species biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0050665 ! hydrogen peroxide biosynthetic process
relationship: negatively_regulates GO:0050665 ! hydrogen peroxide biosynthetic process

[Term]
id: GO:0010731
name: protein glutathionylation
namespace: biological_process
def: "The protein modification process in which a glutathione molecule is added to a protein amino acid through a disulfide linkage." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]
synonym: "protein amino acid glutathionylation" EXACT [GOC:bf]
is_a: GO:0006464 ! cellular protein modification process

[Term]
id: GO:0010732
name: regulation of protein glutathionylation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of protein glutathionylation. Protein glutathionylation is the protein modification process in which a glutathione molecule is added to a protein amino acid through a disulfide linkage." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]
synonym: "regulation of protein amino acid glutathionylation" EXACT [GOC:bf]
is_a: GO:0031399 ! regulation of protein modification process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010731 ! protein glutathionylation
relationship: regulates GO:0010731 ! protein glutathionylation

[Term]
id: GO:0010733
name: positive regulation of protein glutathionylation
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of protein glutathionylation. Protein glutathionylation is the protein modification process in which a glutathione molecule is added to a protein amino acid through a disulfide linkage." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]
synonym: "positive regulation of protein amino acid glutathionylation" EXACT [GOC:bf]
is_a: GO:0010732 ! regulation of protein glutathionylation
is_a: GO:0031401 ! positive regulation of protein modification process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010731 ! protein glutathionylation
relationship: positively_regulates GO:0010731 ! protein glutathionylation

[Term]
id: GO:0010734
name: negative regulation of protein glutathionylation
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of protein glutathionylation. Protein glutathionylation is the protein modification process in which a glutathione molecule is added to a protein amino acid through a disulfide linkage." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]
synonym: "negative regulation of protein amino acid glutathionylation" EXACT [GOC:bf]
is_a: GO:0010732 ! regulation of protein glutathionylation
is_a: GO:0031400 ! negative regulation of protein modification process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010731 ! protein glutathionylation
relationship: negatively_regulates GO:0010731 ! protein glutathionylation

[Term]
id: GO:0010735
name: positive regulation of transcription via serum response element binding
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the specifically regulated synthesis of RNA from DNA encoding a specific set of genes as a result of a transcription factor interacting with a serum response element (SRE). A serum response element is a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter

[Term]
id: GO:0010736
name: serum response element binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the serum response element (SRE), a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]
comment: Note that as agreed during the transcription overhaul, terms specifying binding to specific transcription regulatory motifs are no longer being created. The level of specificity GO has decided to go to is the "core promoter", "core promoter proximal region" and "enhancer". To capture more detail, please consider using column 16.
is_a: GO:0044212 ! transcription regulatory region DNA binding

[Term]
id: GO:0010737
name: protein kinase A signaling
namespace: biological_process
def: "A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "PKA signaling cascade" RELATED [GOC:dph, GOC:tb]
synonym: "protein kinase A signal transduction" EXACT [GOC:signaling]
synonym: "protein kinase A signaling cascade" RELATED [GOC:signaling]
synonym: "protein kinase A signalling cascade" RELATED [GOC:mah]
is_a: GO:0035556 ! intracellular signal transduction

[Term]
id: GO:0010738
name: regulation of protein kinase A signaling
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of protein kinase A signaling. PKA signaling is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "regulation of PKA signaling cascade" RELATED [GOC:dph, GOC:tb]
synonym: "regulation of protein kinase A signaling cascade" RELATED [GOC:signaling]
synonym: "regulation of protein kinase A signalling cascade" RELATED [GOC:mah]
is_a: GO:1902531 ! regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010737 ! protein kinase A signaling
relationship: regulates GO:0010737 ! protein kinase A signaling

[Term]
id: GO:0010739
name: positive regulation of protein kinase A signaling
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of protein kinase A signaling. PKA signaling is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "positive regulation of PKA signaling cascade" RELATED [GOC:dph, GOC:tb]
synonym: "positive regulation of protein kinase A signaling cascade" RELATED [GOC:signaling]
synonym: "positive regulation of protein kinase A signalling cascade" RELATED [GOC:mah]
is_a: GO:0010738 ! regulation of protein kinase A signaling
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010737 ! protein kinase A signaling
relationship: positively_regulates GO:0010737 ! protein kinase A signaling

[Term]
id: GO:0010742
name: macrophage derived foam cell differentiation
namespace: biological_process
def: "The process in which a monocyte acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions." [GOC:add, GOC:dph, GOC:tb]
is_a: GO:0090077 ! foam cell differentiation

[Term]
id: GO:0010743
name: regulation of macrophage derived foam cell differentiation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions." [GOC:add, GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0045595 ! regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010742 ! macrophage derived foam cell differentiation
relationship: regulates GO:0010742 ! macrophage derived foam cell differentiation

[Term]
id: GO:0010744
name: positive regulation of macrophage derived foam cell differentiation
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions." [GOC:add, GOC:dph, GOC:tb]
is_a: GO:0010743 ! regulation of macrophage derived foam cell differentiation
is_a: GO:0045597 ! positive regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010742 ! macrophage derived foam cell differentiation
relationship: positively_regulates GO:0010742 ! macrophage derived foam cell differentiation

[Term]
id: GO:0010745
name: negative regulation of macrophage derived foam cell differentiation
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions." [GOC:add, GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010743 ! regulation of macrophage derived foam cell differentiation
is_a: GO:0045596 ! negative regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010742 ! macrophage derived foam cell differentiation
relationship: negatively_regulates GO:0010742 ! macrophage derived foam cell differentiation

[Term]
id: GO:0010746
name: regulation of plasma membrane long-chain fatty acid transport
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of plasma membrane long-chain fatty acid transport. Plasma membrane long-chain fatty acid transport is the directed movement of long-chain fatty acids across the plasma membrane. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [CHEBI:15904, GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:1903959 ! regulation of anion transmembrane transport
is_a: GO:2000191 ! regulation of fatty acid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0015911 ! plasma membrane long-chain fatty acid transport
relationship: regulates GO:0015911 ! plasma membrane long-chain fatty acid transport

[Term]
id: GO:0010747
name: positive regulation of plasma membrane long-chain fatty acid transport
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of plasma membrane long-chain fatty acid transport. Plasma membrane long-chain fatty acid transport is the directed movement of long-chain fatty acids across the plasma membrane. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [CHEBI:15904, GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010746 ! regulation of plasma membrane long-chain fatty acid transport
is_a: GO:1903961 ! positive regulation of anion transmembrane transport
is_a: GO:2000193 ! positive regulation of fatty acid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0015911 ! plasma membrane long-chain fatty acid transport
relationship: positively_regulates GO:0015911 ! plasma membrane long-chain fatty acid transport

[Term]
id: GO:0010748
name: negative regulation of plasma membrane long-chain fatty acid transport
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of plasma membrane long-chain fatty acid transport. Plasma membrane long-chain fatty acid transport is the directed movement of long-chain fatty acids across the plasma membrane." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010746 ! regulation of plasma membrane long-chain fatty acid transport
is_a: GO:1903960 ! negative regulation of anion transmembrane transport
is_a: GO:2000192 ! negative regulation of fatty acid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0015911 ! plasma membrane long-chain fatty acid transport
relationship: negatively_regulates GO:0015911 ! plasma membrane long-chain fatty acid transport

[Term]
id: GO:0010749
name: regulation of nitric oxide mediated signal transduction
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is a series of molecular signals mediated by the detection of nitric oxide (NO)." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "regulation of nitric oxide-mediated signal transduction" EXACT []
is_a: GO:1902531 ! regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007263 ! nitric oxide mediated signal transduction
relationship: regulates GO:0007263 ! nitric oxide mediated signal transduction

[Term]
id: GO:0010750
name: positive regulation of nitric oxide mediated signal transduction
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is a series of molecular signals mediated by the detection of nitric oxide (NO)." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "positive regulation of nitric oxide-mediated signal transduction" EXACT []
is_a: GO:0010749 ! regulation of nitric oxide mediated signal transduction
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007263 ! nitric oxide mediated signal transduction
relationship: positively_regulates GO:0007263 ! nitric oxide mediated signal transduction

[Term]
id: GO:0010751
name: negative regulation of nitric oxide mediated signal transduction
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is a series of molecular signals mediated by the detection of nitric oxide (NO)." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "negative regulation of nitric oxide-mediated signal transduction" EXACT []
is_a: GO:0010749 ! regulation of nitric oxide mediated signal transduction
is_a: GO:1902532 ! negative regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007263 ! nitric oxide mediated signal transduction
relationship: negatively_regulates GO:0007263 ! nitric oxide mediated signal transduction

[Term]
id: GO:0010752
name: regulation of cGMP-mediated signaling
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of cGMP-mediated signaling. cGMP-mediated signaling is a series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "regulation of cGMP-mediated signalling" EXACT [GOC:mah]
is_a: GO:1902531 ! regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019934 ! cGMP-mediated signaling
relationship: regulates GO:0019934 ! cGMP-mediated signaling

[Term]
id: GO:0010753
name: positive regulation of cGMP-mediated signaling
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of cGMP-mediated signaling. cGMP-mediated signaling is a series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "positive regulation of cGMP-mediated signalling" EXACT [GOC:mah]
is_a: GO:0010752 ! regulation of cGMP-mediated signaling
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0019934 ! cGMP-mediated signaling
relationship: positively_regulates GO:0019934 ! cGMP-mediated signaling

[Term]
id: GO:0010754
name: negative regulation of cGMP-mediated signaling
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of cGMP-mediated signaling. cGMP-mediated signaling is a series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "negative regulation of cGMP-mediated signalling" EXACT [GOC:mah]
is_a: GO:0010752 ! regulation of cGMP-mediated signaling
is_a: GO:1902532 ! negative regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019934 ! cGMP-mediated signaling
relationship: negatively_regulates GO:0019934 ! cGMP-mediated signaling

[Term]
id: GO:0010755
name: regulation of plasminogen activation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0070613 ! regulation of protein processing
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031639 ! plasminogen activation
relationship: regulates GO:0031639 ! plasminogen activation

[Term]
id: GO:0010756
name: positive regulation of plasminogen activation
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010755 ! regulation of plasminogen activation
is_a: GO:0010954 ! positive regulation of protein processing
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0031639 ! plasminogen activation
relationship: positively_regulates GO:0031639 ! plasminogen activation

[Term]
id: GO:0010757
name: negative regulation of plasminogen activation
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "inhibition of plasminogen activation" NARROW [GOC:dph, GOC:tb]
is_a: GO:0010755 ! regulation of plasminogen activation
is_a: GO:0010955 ! negative regulation of protein processing
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0031639 ! plasminogen activation
relationship: negatively_regulates GO:0031639 ! plasminogen activation

[Term]
id: GO:0010758
name: regulation of macrophage chemotaxis
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0002688 ! regulation of leukocyte chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048246 ! macrophage chemotaxis
relationship: regulates GO:0048246 ! macrophage chemotaxis

[Term]
id: GO:0010759
name: positive regulation of macrophage chemotaxis
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis
is_a: GO:0010758 ! regulation of macrophage chemotaxis
is_a: GO:0071622 ! regulation of granulocyte chemotaxis
is_a: GO:0071675 ! regulation of mononuclear cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048246 ! macrophage chemotaxis
relationship: positively_regulates GO:0048246 ! macrophage chemotaxis

[Term]
id: GO:0010760
name: negative regulation of macrophage chemotaxis
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis
is_a: GO:0010758 ! regulation of macrophage chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048246 ! macrophage chemotaxis
relationship: negatively_regulates GO:0048246 ! macrophage chemotaxis

[Term]
id: GO:0010761
name: fibroblast migration
namespace: biological_process
def: "Cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium. A fibroblast is a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "fibroblast cell migration" EXACT [GOC:dph]
is_a: GO:0001667 ! ameboidal-type cell migration

[Term]
id: GO:0010762
name: regulation of fibroblast migration
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium." [GOC:dph, GOC:tb]
synonym: "regulation of fibroblast cell migration" EXACT [GOC:dph]
is_a: GO:0030334 ! regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010761 ! fibroblast migration
relationship: regulates GO:0010761 ! fibroblast migration

[Term]
id: GO:0010763
name: positive regulation of fibroblast migration
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "positive regulation of fibroblast cell migration" EXACT [GOC:dph]
is_a: GO:0010762 ! regulation of fibroblast migration
is_a: GO:0030335 ! positive regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010761 ! fibroblast migration
relationship: positively_regulates GO:0010761 ! fibroblast migration

[Term]
id: GO:0010764
name: negative regulation of fibroblast migration
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium." [GOC:dph, GOC:tb]
synonym: "negative regulation of fibroblast cell migration" EXACT [GOC:dph]
is_a: GO:0010762 ! regulation of fibroblast migration
is_a: GO:0030336 ! negative regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010761 ! fibroblast migration
relationship: negatively_regulates GO:0010761 ! fibroblast migration

[Term]
id: GO:0010765
name: positive regulation of sodium ion transport
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb]
is_a: GO:0002028 ! regulation of sodium ion transport
is_a: GO:0043270 ! positive regulation of ion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006814 ! sodium ion transport
relationship: positively_regulates GO:0006814 ! sodium ion transport

[Term]
id: GO:0010766
name: negative regulation of sodium ion transport
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb]
is_a: GO:0002028 ! regulation of sodium ion transport
is_a: GO:0043271 ! negative regulation of ion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006814 ! sodium ion transport
relationship: negatively_regulates GO:0006814 ! sodium ion transport

[Term]
id: GO:0010767
name: regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a UV damage stimulus." [GOC:dph, GOC:tb]
is_a: GO:0034644 ! cellular response to UV
is_a: GO:0043618 ! regulation of transcription from RNA polymerase II promoter in response to stress

[Term]
id: GO:0010768
name: negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a UV damage stimulus." [GOC:dph, GOC:tb]
is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
is_a: GO:0010767 ! regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage

[Term]
id: GO:0010769
name: regulation of cell morphogenesis involved in differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:dph, GOC:tb]
is_a: GO:0022604 ! regulation of cell morphogenesis
is_a: GO:0060284 ! regulation of cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000904 ! cell morphogenesis involved in differentiation
relationship: regulates GO:0000904 ! cell morphogenesis involved in differentiation

[Term]
id: GO:0010770
name: positive regulation of cell morphogenesis involved in differentiation
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:dph, GOC:tb]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation
is_a: GO:0051130 ! positive regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000904 ! cell morphogenesis involved in differentiation
relationship: positively_regulates GO:0000904 ! cell morphogenesis involved in differentiation

[Term]
id: GO:0010771
name: negative regulation of cell morphogenesis involved in differentiation
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:dph, GOC:tb]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation
is_a: GO:0051129 ! negative regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000904 ! cell morphogenesis involved in differentiation
relationship: negatively_regulates GO:0000904 ! cell morphogenesis involved in differentiation

[Term]
id: GO:0010772
name: meiotic DNA recombinase assembly involved in reciprocal meiotic recombination
namespace: biological_process
def: "The aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form higher order oligomers on single-stranded DNA resulting in meiotic recombination. Meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb]
is_a: GO:0000707 ! meiotic DNA recombinase assembly
intersection_of: GO:0000707 ! meiotic DNA recombinase assembly
intersection_of: part_of GO:0007131 ! reciprocal meiotic recombination
relationship: part_of GO:0007131 ! reciprocal meiotic recombination

[Term]
id: GO:0010773
name: meiotic DNA recombinase assembly involved in meiotic gene conversion
namespace: biological_process
def: "The aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form higher order oligomers on single-stranded DNA resulting in meiotic gene conversion. Meiotic gene conversion is the cell cycle process in which genetic information is transferred from one helix to another." [GOC:dph, GOC:tb]
is_a: GO:0000707 ! meiotic DNA recombinase assembly
intersection_of: GO:0000707 ! meiotic DNA recombinase assembly
intersection_of: part_of GO:0006311 ! meiotic gene conversion
relationship: part_of GO:0006311 ! meiotic gene conversion

[Term]
id: GO:0010774
name: meiotic strand invasion involved in reciprocal meiotic recombination
namespace: biological_process
def: "The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate resulting in meiotic recombination. Meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb]
is_a: GO:0000708 ! meiotic strand invasion
intersection_of: GO:0000708 ! meiotic strand invasion
intersection_of: part_of GO:0007131 ! reciprocal meiotic recombination
relationship: part_of GO:0007131 ! reciprocal meiotic recombination

[Term]
id: GO:0010775
name: meiotic strand invasion involved in meiotic gene conversion
namespace: biological_process
def: "The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate resulting in meiotic recombination." [GOC:dph, GOC:tb]
is_a: GO:0000708 ! meiotic strand invasion
intersection_of: GO:0000708 ! meiotic strand invasion
intersection_of: part_of GO:0006311 ! meiotic gene conversion
relationship: part_of GO:0006311 ! meiotic gene conversion

[Term]
id: GO:0010776
name: meiotic mismatch repair involved in meiotic gene conversion
namespace: biological_process
def: "A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules resulting in meiotic gene conversion. Meiotic gene conversion is the cell cycle process in which genetic information is transferred from one helix to another." [GOC:dph, GOC:tb]
is_a: GO:0000710 ! meiotic mismatch repair
intersection_of: GO:0000710 ! meiotic mismatch repair
intersection_of: part_of GO:0006311 ! meiotic gene conversion
relationship: part_of GO:0006311 ! meiotic gene conversion

[Term]
id: GO:0010777
name: meiotic mismatch repair involved in reciprocal meiotic recombination
namespace: biological_process
def: "A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules resulting in meiotic recombination. Meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb]
is_a: GO:0000710 ! meiotic mismatch repair
intersection_of: GO:0000710 ! meiotic mismatch repair
intersection_of: part_of GO:0007131 ! reciprocal meiotic recombination
relationship: part_of GO:0007131 ! reciprocal meiotic recombination

[Term]
id: GO:0010778
name: meiotic DNA repair synthesis involved in reciprocal meiotic recombination
namespace: biological_process
def: "The synthesis of DNA proceeding from the broken 3' single-strand DNA end that uses the homologous intact duplex as the template resulting in meiotic recombination. Meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb]
is_a: GO:0000711 ! meiotic DNA repair synthesis
intersection_of: GO:0000711 ! meiotic DNA repair synthesis
intersection_of: part_of GO:0007131 ! reciprocal meiotic recombination
relationship: part_of GO:0007131 ! reciprocal meiotic recombination

[Term]
id: GO:0010779
name: meiotic DNA repair synthesis involved in meiotic gene conversion
namespace: biological_process
def: "The synthesis of DNA proceeding from the broken 3' single-strand DNA end that uses the homologous intact duplex as the template resulting in meiotic gene conversion. Meiotic gene conversion is the cell cycle process in which genetic information is transferred from one helix to another." [GOC:dph, GOC:tb]
is_a: GO:0000711 ! meiotic DNA repair synthesis
intersection_of: GO:0000711 ! meiotic DNA repair synthesis
intersection_of: part_of GO:0006311 ! meiotic gene conversion
relationship: part_of GO:0006311 ! meiotic gene conversion

[Term]
id: GO:0010780
name: meiotic DNA double-strand break formation involved in reciprocal meiotic recombination
namespace: biological_process
def: "The cell cycle process in which double-strand breaks are generated at defined hotspots throughout the genome during meiosis I resulting in meiotic recombination. Meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb]
is_a: GO:0042138 ! meiotic DNA double-strand break formation
intersection_of: GO:0042138 ! meiotic DNA double-strand break formation
intersection_of: part_of GO:0007131 ! reciprocal meiotic recombination
relationship: part_of GO:0007131 ! reciprocal meiotic recombination

[Term]
id: GO:0010781
name: meiotic DNA double-strand break formation involved in meiotic gene conversion
namespace: biological_process
def: "The cell cycle process in which double-strand breaks are generated at defined hotspots throughout the genome during meiosis I resulting in meiotic gene conversion. Meiotic gene conversion is the cell cycle process in which genetic information is transferred from one helix to another." [GOC:dph, GOC:tb]
is_a: GO:0042138 ! meiotic DNA double-strand break formation
intersection_of: GO:0042138 ! meiotic DNA double-strand break formation
intersection_of: part_of GO:0006311 ! meiotic gene conversion
relationship: part_of GO:0006311 ! meiotic gene conversion

[Term]
id: GO:0010782
name: proboscis morphogenesis, labial disc-derived
namespace: biological_process
def: "The process in which the anatomical structures of the proboscis that are derived from the labial disc are generated and organized." [GOC:dph, GOC:tb]
is_a: GO:0009886 ! post-embryonic morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0007454 ! labial disc morphogenesis
relationship: part_of GO:0048734 ! proboscis morphogenesis

[Term]
id: GO:0010783
name: proboscis morphogenesis, eye-antennal disc-derived
namespace: biological_process
def: "The process in which the anatomical structures of the proboscis that are derived from the eye-antennal disc are generated and organized." [GOC:dph, GOC:tb]
is_a: GO:0009886 ! post-embryonic morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0007455 ! eye-antennal disc morphogenesis
relationship: part_of GO:0048734 ! proboscis morphogenesis

[Term]
id: GO:0010784
name: proboscis morphogenesis, clypeo-labral disc-derived
namespace: biological_process
def: "The process in which the anatomical structures of the proboscis that are derived from the clypeo-labral disc are generated and organized." [GOC:dph, GOC:tb]
is_a: GO:0009886 ! post-embryonic morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0007453 ! clypeo-labral disc morphogenesis
relationship: part_of GO:0048734 ! proboscis morphogenesis

[Term]
id: GO:0010785
name: clathrin coating of Golgi vesicle, plasma membrane to endosome targeting
namespace: biological_process
def: "The addition of clathrin and adaptor proteins to Golgi membranes during the formation of transport vesicles that will move from the plasma membrane to the endosome, forming a vesicle coat." [GOC:dph, GOC:tb]
is_a: GO:0048202 ! clathrin coating of Golgi vesicle
relationship: part_of GO:0048201 ! vesicle targeting, plasma membrane to endosome

[Term]
id: GO:0010786
name: clathrin coating of Golgi vesicle, trans-Golgi to endosome targeting
namespace: biological_process
def: "The addition of clathrin and adaptor proteins to Golgi membranes during the formation of transport vesicles that will move from the trans-Golgi to the endosome, forming a vesicle coat." [GOC:dph, GOC:tb]
is_a: GO:0048202 ! clathrin coating of Golgi vesicle
relationship: part_of GO:0048203 ! vesicle targeting, trans-Golgi to endosome

[Term]
id: GO:0010787
name: COPI coating of Golgi vesicle, inter-Golgi cisterna
namespace: biological_process
def: "The addition of COPI proteins and adaptor proteins to Golgi membranes during the formation of inter-Golgi cisterna transport vesicles, forming a vesicle coat." [GOC:dph, GOC:tb]
is_a: GO:0048205 ! COPI coating of Golgi vesicle
relationship: part_of GO:0048204 ! vesicle targeting, inter-Golgi cisterna

[Term]
id: GO:0010788
name: COPI coating of Golgi vesicle, cis-Golgi to rough ER
namespace: biological_process
def: "The addition of COPI proteins and adaptor proteins to Golgi membranes during the formation of cis-Golgi to rough ER transport vesicles, forming a vesicle coat." [GOC:dph, GOC:tb]
is_a: GO:0048205 ! COPI coating of Golgi vesicle
relationship: part_of GO:0048206 ! vesicle targeting, cis-Golgi to rough ER

[Term]
id: GO:0010789
name: meiotic sister chromatid cohesion involved in meiosis I
namespace: biological_process
def: "The cell cycle process in which sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during meiosis I." [GOC:dph, GOC:tb]
is_a: GO:0051177 ! meiotic sister chromatid cohesion
intersection_of: GO:0051177 ! meiotic sister chromatid cohesion
intersection_of: part_of GO:0007127 ! meiosis I
relationship: part_of GO:0007127 ! meiosis I

[Term]
id: GO:0010790
name: meiotic sister chromatid cohesion involved in meiosis II
namespace: biological_process
def: "The cell cycle process in which sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during meiosis II." [GOC:dph, GOC:tb]
is_a: GO:0051177 ! meiotic sister chromatid cohesion
relationship: part_of GO:0007135 ! meiosis II

[Term]
id: GO:0010791
name: DNA double-strand break processing involved in repair via synthesis-dependent strand annealing
namespace: biological_process
def: "The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang that results in the repair of a double strand break via synthesis-dependent strand annealing." [GOC:dph, GOC:tb]
is_a: GO:0000729 ! DNA double-strand break processing
intersection_of: GO:0000729 ! DNA double-strand break processing
intersection_of: part_of GO:0045003 ! double-strand break repair via synthesis-dependent strand annealing
relationship: part_of GO:0045003 ! double-strand break repair via synthesis-dependent strand annealing

[Term]
id: GO:0010792
name: DNA double-strand break processing involved in repair via single-strand annealing
namespace: biological_process
def: "The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang that results in the repair of a double strand break via single-strand annealing." [GOC:dph, GOC:tb]
is_a: GO:0000729 ! DNA double-strand break processing
intersection_of: GO:0000729 ! DNA double-strand break processing
intersection_of: part_of GO:0045002 ! double-strand break repair via single-strand annealing
relationship: part_of GO:0045002 ! double-strand break repair via single-strand annealing

[Term]
id: GO:0010793
name: regulation of mRNA export from nucleus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of mRNA from the nucleus to the cytoplasm." [GOC:dph, GOC:tb]
is_a: GO:0010468 ! regulation of gene expression
is_a: GO:0046831 ! regulation of RNA export from nucleus
is_a: GO:2000197 ! regulation of ribonucleoprotein complex localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006406 ! mRNA export from nucleus
relationship: regulates GO:0006406 ! mRNA export from nucleus

[Term]
id: GO:0010794
name: regulation of dolichol biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dolichol biosynthesis. Dolichol biosynthesis consists of the chemical reactions and pathways resulting in the formation of dolichols, any 2,3-dihydropolyprenol derived from four or more linked isoprene units." [GOC:dph, GOC:tb]
is_a: GO:0019747 ! regulation of isoprenoid metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0046890 ! regulation of lipid biosynthetic process
is_a: GO:1902930 ! regulation of alcohol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019408 ! dolichol biosynthetic process
relationship: regulates GO:0019408 ! dolichol biosynthetic process

[Term]
id: GO:0010795
name: regulation of ubiquinone biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ubiquinone biosynthesis. Ubiquinone biosynthesis consists of the chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:dph, GOC:tb]
is_a: GO:0010566 ! regulation of ketone biosynthetic process
is_a: GO:0051196 ! regulation of coenzyme metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006744 ! ubiquinone biosynthetic process
relationship: regulates GO:0006744 ! ubiquinone biosynthetic process

[Term]
id: GO:0010796
name: regulation of multivesicular body size
namespace: biological_process
def: "Any process that modulates the volume of a multivesicular body, a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles." [GOC:dph, GOC:jp, GOC:tb]
is_a: GO:0051036 ! regulation of endosome size

[Term]
id: GO:0010797
name: regulation of multivesicular body size involved in endosome transport
namespace: biological_process
def: "Any process that modulates the volume of a multivesicular body as part of the directed movement of substances from endosomes to lysosomes or vacuoles." [GOC:dph, GOC:tb]
is_a: GO:0010796 ! regulation of multivesicular body size
intersection_of: GO:0010796 ! regulation of multivesicular body size
intersection_of: part_of GO:0016197 ! endosomal transport
relationship: part_of GO:0016197 ! endosomal transport
relationship: part_of GO:0032509 ! endosome transport via multivesicular body sorting pathway

[Term]
id: GO:0010798
name: regulation of multivesicular body size involved in ubiquitin-dependent protein catabolism
namespace: biological_process
def: "Any process that modulates the volume of a multivesicular body as part of the chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin." [GOC:dph, GOC:tb]
is_a: GO:0010796 ! regulation of multivesicular body size
intersection_of: GO:0010796 ! regulation of multivesicular body size
intersection_of: part_of GO:0006511 ! ubiquitin-dependent protein catabolic process
relationship: part_of GO:0006511 ! ubiquitin-dependent protein catabolic process

[Term]
id: GO:0010799
name: regulation of peptidyl-threonine phosphorylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [GOC:dph, GOC:tb]
is_a: GO:0001932 ! regulation of protein phosphorylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0018107 ! peptidyl-threonine phosphorylation
relationship: regulates GO:0018107 ! peptidyl-threonine phosphorylation

[Term]
id: GO:0010800
name: positive regulation of peptidyl-threonine phosphorylation
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [GOC:dph, GOC:tb]
is_a: GO:0001934 ! positive regulation of protein phosphorylation
is_a: GO:0010799 ! regulation of peptidyl-threonine phosphorylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0018107 ! peptidyl-threonine phosphorylation
relationship: positively_regulates GO:0018107 ! peptidyl-threonine phosphorylation

[Term]
id: GO:0010801
name: negative regulation of peptidyl-threonine phosphorylation
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [GOC:dph, GOC:tb]
is_a: GO:0001933 ! negative regulation of protein phosphorylation
is_a: GO:0010799 ! regulation of peptidyl-threonine phosphorylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0018107 ! peptidyl-threonine phosphorylation
relationship: negatively_regulates GO:0018107 ! peptidyl-threonine phosphorylation

[Term]
id: GO:0010803
name: regulation of tumor necrosis factor-mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor." [GOC:dph, GOC:tb]
synonym: "regulation of TNF signaling" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of TNF-mediated signaling pathway" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of tumor necrosis factor-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0033209 ! tumor necrosis factor-mediated signaling pathway
relationship: regulates GO:0033209 ! tumor necrosis factor-mediated signaling pathway

[Term]
id: GO:0010804
name: negative regulation of tumor necrosis factor-mediated signaling pathway
namespace: biological_process
def: "Any process that decreases the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor." [GOC:dph, GOC:tb]
synonym: "negative regulation of TNF signaling" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of TNF-mediated signaling pathway" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of tumor necrosis factor-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway
is_a: GO:0010803 ! regulation of tumor necrosis factor-mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0033209 ! tumor necrosis factor-mediated signaling pathway
relationship: negatively_regulates GO:0033209 ! tumor necrosis factor-mediated signaling pathway

[Term]
id: GO:0010805
name: regulation of lysine import
namespace: biological_process
def: "Any process that modulates the rate or frequency of lysine import. Lysine import is the directed movement of lysine, 2,6-diaminohexanoic acid, into a cell or organelle." [GOC:dph, GOC:tb]
synonym: "regulation of lysine uptake" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010958 ! regulation of amino acid import
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034226 ! lysine import
relationship: regulates GO:0034226 ! lysine import

[Term]
id: GO:0010806
name: negative regulation of lysine import
namespace: biological_process
def: "Any process that decreases the rate or frequency of lysine import. Lysine import is the directed movement of lysine, 2,6-diaminohexanoic acid, into a cell or organelle." [GOC:dph, GOC:tb]
synonym: "negative regulation of lysine uptake" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010805 ! regulation of lysine import
is_a: GO:0051956 ! negative regulation of amino acid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034226 ! lysine import
relationship: negatively_regulates GO:0034226 ! lysine import

[Term]
id: GO:0010807
name: regulation of synaptic vesicle priming
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion." [GOC:dph, GOC:kmv, GOC:tb, PMID:15489511]
is_a: GO:0043254 ! regulation of protein complex assembly
is_a: GO:2000300 ! regulation of synaptic vesicle exocytosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016082 ! synaptic vesicle priming
relationship: regulates GO:0016082 ! synaptic vesicle priming

[Term]
id: GO:0010808
name: positive regulation of synaptic vesicle priming
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion." [GOC:dph, GOC:kmv, GOC:tb, PMID:15489511]
is_a: GO:0010807 ! regulation of synaptic vesicle priming
is_a: GO:0031334 ! positive regulation of protein complex assembly
is_a: GO:2000302 ! positive regulation of synaptic vesicle exocytosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016082 ! synaptic vesicle priming
relationship: positively_regulates GO:0016082 ! synaptic vesicle priming

[Term]
id: GO:0010809
name: negative regulation of synaptic vesicle priming
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion." [GOC:dph, GOC:kmvs, GOC:tb, PMID:15489511]
is_a: GO:0010807 ! regulation of synaptic vesicle priming
is_a: GO:0031333 ! negative regulation of protein complex assembly
is_a: GO:2000301 ! negative regulation of synaptic vesicle exocytosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016082 ! synaptic vesicle priming
relationship: negatively_regulates GO:0016082 ! synaptic vesicle priming

[Term]
id: GO:0010810
name: regulation of cell-substrate adhesion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules." [GOC:dph, GOC:pf, GOC:tb]
is_a: GO:0030155 ! regulation of cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031589 ! cell-substrate adhesion
relationship: regulates GO:0031589 ! cell-substrate adhesion

[Term]
id: GO:0010811
name: positive regulation of cell-substrate adhesion
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules." [GOC:dph, GOC:pf, GOC:tb]
is_a: GO:0010810 ! regulation of cell-substrate adhesion
is_a: GO:0045785 ! positive regulation of cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0031589 ! cell-substrate adhesion
relationship: positively_regulates GO:0031589 ! cell-substrate adhesion

[Term]
id: GO:0010812
name: negative regulation of cell-substrate adhesion
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules." [GOC:dph, GOC:pf, GOC:tb]
is_a: GO:0007162 ! negative regulation of cell adhesion
is_a: GO:0010810 ! regulation of cell-substrate adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0031589 ! cell-substrate adhesion
relationship: negatively_regulates GO:0031589 ! cell-substrate adhesion

[Term]
id: GO:0010813
name: neuropeptide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of neuropeptides. Neuropeptides are signaling peptides that travel across a synaptic junction." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0043171 ! peptide catabolic process

[Term]
id: GO:0010814
name: substance P catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the neuropeptide substance P." [GOC:BHF, GOC:rl]
is_a: GO:0010813 ! neuropeptide catabolic process

[Term]
id: GO:0010815
name: bradykinin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the peptide bradykinin." [GOC:BHF, GOC:rl]
is_a: GO:0043171 ! peptide catabolic process

[Term]
id: GO:0010816
name: calcitonin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the peptide calcitonin." [GOC:BHF, GOC:rl]
is_a: GO:0034754 ! cellular hormone metabolic process
is_a: GO:0042447 ! hormone catabolic process
is_a: GO:0043171 ! peptide catabolic process

[Term]
id: GO:0010817
name: regulation of hormone levels
namespace: biological_process
def: "Any process that modulates the levels of hormone within an organism or a tissue. A hormone is any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0010818
name: T cell chemotaxis
namespace: biological_process
def: "The directed movement of a T cell in response to an external stimulus. A T cell is a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex." [GOC:dph, GOC:tb]
synonym: "T-cell chemotaxis" EXACT [CL:0000084]
is_a: GO:0048247 ! lymphocyte chemotaxis
is_a: GO:0072678 ! T cell migration

[Term]
id: GO:0010819
name: regulation of T cell chemotaxis
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus." [GOC:dph, GOC:tb]
is_a: GO:1901623 ! regulation of lymphocyte chemotaxis
is_a: GO:2000404 ! regulation of T cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010818 ! T cell chemotaxis
relationship: regulates GO:0010818 ! T cell chemotaxis

[Term]
id: GO:0010820
name: positive regulation of T cell chemotaxis
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis
is_a: GO:0010819 ! regulation of T cell chemotaxis
is_a: GO:2000406 ! positive regulation of T cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010818 ! T cell chemotaxis
relationship: positively_regulates GO:0010818 ! T cell chemotaxis

[Term]
id: GO:0010821
name: regulation of mitochondrion organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." [GOC:dph, GOC:tb]
synonym: "regulation of mitochondrion organisation" EXACT [GOC:mah]
is_a: GO:0033043 ! regulation of organelle organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007005 ! mitochondrion organization
relationship: regulates GO:0007005 ! mitochondrion organization

[Term]
id: GO:0010822
name: positive regulation of mitochondrion organization
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." [GOC:dph, GOC:tb]
synonym: "positive regulation of mitochondrion organisation" EXACT [GOC:mah]
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:0010821 ! regulation of mitochondrion organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007005 ! mitochondrion organization
relationship: positively_regulates GO:0007005 ! mitochondrion organization

[Term]
id: GO:0010823
name: negative regulation of mitochondrion organization
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." [GOC:dph, GOC:tb]
synonym: "negative regulation of mitochondrion organisation" EXACT [GOC:mah]
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:0010821 ! regulation of mitochondrion organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007005 ! mitochondrion organization
relationship: negatively_regulates GO:0007005 ! mitochondrion organization

[Term]
id: GO:0010824
name: regulation of centrosome duplication
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:dph, GOC:tb]
is_a: GO:0046605 ! regulation of centrosome cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051298 ! centrosome duplication
relationship: regulates GO:0051298 ! centrosome duplication

[Term]
id: GO:0010825
name: positive regulation of centrosome duplication
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:dph, GOC:tb]
is_a: GO:0010824 ! regulation of centrosome duplication
is_a: GO:0046607 ! positive regulation of centrosome cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051298 ! centrosome duplication
relationship: positively_regulates GO:0051298 ! centrosome duplication

[Term]
id: GO:0010826
name: negative regulation of centrosome duplication
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:dph, GOC:tb]
is_a: GO:0010824 ! regulation of centrosome duplication
is_a: GO:0046606 ! negative regulation of centrosome cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051298 ! centrosome duplication
relationship: negatively_regulates GO:0051298 ! centrosome duplication

[Term]
id: GO:0010827
name: regulation of glucose transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glucose transport. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb]
xref: Reactome:REACT_100137 "Regulation of Glucokinase by Glucokinase Regulatory Protein, Plasmodium falciparum"
xref: Reactome:REACT_107583 "Regulation of Glucokinase by Glucokinase Regulatory Protein, Schizosaccharomyces pombe"
xref: Reactome:REACT_31327 "Regulation of Glucokinase by Glucokinase Regulatory Protein, Rattus norvegicus"
xref: Reactome:REACT_32616 "Regulation of Glucokinase by Glucokinase Regulatory Protein, Mus musculus"
xref: Reactome:REACT_6804 "Regulation of Glucokinase by Glucokinase Regulatory Protein, Homo sapiens"
xref: Reactome:REACT_79618 "Regulation of Glucokinase by Glucokinase Regulatory Protein, Caenorhabditis elegans"
xref: Reactome:REACT_79739 "Regulation of Glucokinase by Glucokinase Regulatory Protein, Bos taurus"
xref: Reactome:REACT_80307 "Regulation of Glucokinase by Glucokinase Regulatory Protein, Arabidopsis thaliana"
xref: Reactome:REACT_80311 "Regulation of Glucokinase by Glucokinase Regulatory Protein, Canis familiaris"
xref: Reactome:REACT_82890 "Regulation of Glucokinase by Glucokinase Regulatory Protein, Taeniopygia guttata"
xref: Reactome:REACT_83179 "Regulation of Glucokinase by Glucokinase Regulatory Protein, Danio rerio"
xref: Reactome:REACT_84006 "Regulation of Glucokinase by Glucokinase Regulatory Protein, Oryza sativa"
xref: Reactome:REACT_88683 "Regulation of Glucokinase by Glucokinase Regulatory Protein, Xenopus tropicalis"
xref: Reactome:REACT_90901 "Regulation of Glucokinase by Glucokinase Regulatory Protein, Sus scrofa"
xref: Reactome:REACT_98854 "Regulation of Glucokinase by Glucokinase Regulatory Protein, Saccharomyces cerevisiae"
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0015758 ! glucose transport
relationship: regulates GO:0015758 ! glucose transport

[Term]
id: GO:0010828
name: positive regulation of glucose transport
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of glucose transport. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010827 ! regulation of glucose transport
is_a: GO:0051050 ! positive regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0015758 ! glucose transport
relationship: positively_regulates GO:0015758 ! glucose transport

[Term]
id: GO:0010829
name: negative regulation of glucose transport
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of glucose transport. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010827 ! regulation of glucose transport
is_a: GO:0051051 ! negative regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0015758 ! glucose transport
relationship: negatively_regulates GO:0015758 ! glucose transport

[Term]
id: GO:0010830
name: regulation of myotube differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:dph, GOC:tb]
is_a: GO:0051153 ! regulation of striated muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0014902 ! myotube differentiation
relationship: regulates GO:0014902 ! myotube differentiation

[Term]
id: GO:0010831
name: positive regulation of myotube differentiation
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:dph, GOC:tb]
is_a: GO:0010830 ! regulation of myotube differentiation
is_a: GO:0051155 ! positive regulation of striated muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0014902 ! myotube differentiation
relationship: positively_regulates GO:0014902 ! myotube differentiation

[Term]
id: GO:0010832
name: negative regulation of myotube differentiation
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:dph, GOC:tb]
is_a: GO:0010830 ! regulation of myotube differentiation
is_a: GO:0051154 ! negative regulation of striated muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0014902 ! myotube differentiation
relationship: negatively_regulates GO:0014902 ! myotube differentiation

[Term]
id: GO:0010833
name: telomere maintenance via telomere lengthening
namespace: biological_process
def: "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and lengthening the telomeric DNA." [GOC:dph, GOC:tb]
is_a: GO:0000723 ! telomere maintenance

[Term]
id: GO:0010834
name: obsolete telomere maintenance via telomere shortening
namespace: biological_process
def: "OBSOLETE. Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and shortening the telomeric DNA." [GOC:dph, GOC:tb]
comment: This term was made obsolete because it represents a phenotype.
synonym: "telomere maintenance via telomere shortening" EXACT []
is_obsolete: true
consider: GO:1903824

[Term]
id: GO:0010835
name: regulation of protein ADP-ribosylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein ADP-ribosylation. Protein ADP-ribosylation is the transfer, from NAD, of ADP-ribose to protein amino acids." [GOC:dph, GOC:tb]
synonym: "regulation of protein amino acid ADP-ribosylation" EXACT [GOC:bf]
is_a: GO:0060049 ! regulation of protein glycosylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006471 ! protein ADP-ribosylation
relationship: regulates GO:0006471 ! protein ADP-ribosylation

[Term]
id: GO:0010836
name: negative regulation of protein ADP-ribosylation
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of protein ADP-ribosylation. Protein ADP-ribosylation is the transfer, from NAD, of ADP-ribose to protein amino acids." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "negative regulation of protein amino acid ADP-ribosylation" EXACT [GOC:bf]
is_a: GO:0010835 ! regulation of protein ADP-ribosylation
is_a: GO:0060051 ! negative regulation of protein glycosylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006471 ! protein ADP-ribosylation
relationship: negatively_regulates GO:0006471 ! protein ADP-ribosylation

[Term]
id: GO:0010837
name: regulation of keratinocyte proliferation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population." [GOC:dph, GOC:tb]
is_a: GO:0050678 ! regulation of epithelial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043616 ! keratinocyte proliferation
relationship: regulates GO:0043616 ! keratinocyte proliferation

[Term]
id: GO:0010838
name: positive regulation of keratinocyte proliferation
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population." [GOC:dph, GOC:tb]
is_a: GO:0010837 ! regulation of keratinocyte proliferation
is_a: GO:0050679 ! positive regulation of epithelial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043616 ! keratinocyte proliferation
relationship: positively_regulates GO:0043616 ! keratinocyte proliferation

[Term]
id: GO:0010839
name: negative regulation of keratinocyte proliferation
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population." [GOC:dph, GOC:tb]
is_a: GO:0010837 ! regulation of keratinocyte proliferation
is_a: GO:0050680 ! negative regulation of epithelial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043616 ! keratinocyte proliferation
relationship: negatively_regulates GO:0043616 ! keratinocyte proliferation

[Term]
id: GO:0010840
name: regulation of circadian sleep/wake cycle, wakefulness
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the wakeful phase of the circadian sleep/wake cycle. The wakeful phase is the part of the circadian sleep/wake cycle where the organism is not asleep." [GOC:dph, GOC:tb]
is_a: GO:0042749 ! regulation of circadian sleep/wake cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042746 ! circadian sleep/wake cycle, wakefulness
relationship: regulates GO:0042746 ! circadian sleep/wake cycle, wakefulness

[Term]
id: GO:0010841
name: positive regulation of circadian sleep/wake cycle, wakefulness
namespace: biological_process
def: "Any process that increases the frequency, or extent of the wakeful phase of the circadian sleep/wake cycle. The wakeful phase is the part of the circadian sleep/wake cycle where the organism is not asleep." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010840 ! regulation of circadian sleep/wake cycle, wakefulness
is_a: GO:0042753 ! positive regulation of circadian rhythm
is_a: GO:0048520 ! positive regulation of behavior
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042746 ! circadian sleep/wake cycle, wakefulness
relationship: positively_regulates GO:0042746 ! circadian sleep/wake cycle, wakefulness

[Term]
id: GO:0010842
name: retina layer formation
namespace: biological_process
def: "The process in which the vertebrate retina is organized into three laminae: the outer nuclear layer (ONL), which contains photoreceptor nuclei; the inner nuclear layer (INL), which contains amacrine, bipolar and horizontal cells; and the retinal ganglion cell (RGC) layer. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells. The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells. Spanning all layers of the retina are the radially oriented Mueller glia." [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:1270266]
synonym: "retinal lamination" EXACT [GOC:dph, GOC:tb]
synonym: "retinal layer formation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0003407 ! neural retina development
relationship: part_of GO:0060042 ! retina morphogenesis in camera-type eye

[Term]
id: GO:0010843
name: obsolete promoter binding
namespace: molecular_function
def: "OBSOLETE. Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for transcription factor complexes of the basal transcription machinery." [GOC:dph, GOC:tb, SO:0000167]
comment: This term was made obsolete because the word "promoter" is used ambiguously in the literature. It sometimes is used to refer specifically to the "core promoter" region recognized by the basal transcription machinery, and other times is used to refer to a larger regulatory region composed of the core promoter and also the regulatory region adjacent (proximal) to the core promoter. The core promoter proximal region is typically recognized by "regulatory transcription factors", such as Gal4 in S. cerevisiae.
synonym: "DNA binding, transcription promoter" EXACT [GOC:dph, GOC:tb]
synonym: "promoter binding" EXACT []
is_obsolete: true
consider: GO:0001047
consider: GO:0044212

[Term]
id: GO:0010844
name: recombination hotspot binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a region in a genome which promotes recombination." [GOC:dph, GOC:tb]
synonym: "DNA binding, recombination hotspot" EXACT [GOC:dph, GOC:tb]
is_a: GO:0003677 ! DNA binding

[Term]
id: GO:0010845
name: positive regulation of reciprocal meiotic recombination
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb]
synonym: "positive regulation of meiotic recombination" RELATED [GOC:dph, GOC:tb]
is_a: GO:0010520 ! regulation of reciprocal meiotic recombination
is_a: GO:0045911 ! positive regulation of DNA recombination
is_a: GO:0060903 ! positive regulation of meiosis I
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007131 ! reciprocal meiotic recombination
relationship: positively_regulates GO:0007131 ! reciprocal meiotic recombination

[Term]
id: GO:0010846
name: activation of reciprocal meiotic recombination
namespace: biological_process
def: "Any process that starts the inactive process of reciprocal meiotic recombination. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb]
synonym: "activation of meiotic recombination" RELATED [GOC:dph, GOC:tb]
is_a: GO:0010845 ! positive regulation of reciprocal meiotic recombination

[Term]
id: GO:0010847
name: regulation of chromatin assembly
namespace: biological_process
def: "Any process the modulates the frequency, rate or extent of chromatin assembly. Chromatin assembly is the assembly of DNA, histone proteins, and other associated proteins into chromatin structure, beginning with the formation of the basic unit, the nucleosome, followed by organization of the nucleosomes into higher order structures, ultimately giving rise to a complex organization of specific domains within the nucleus." [GOC:dph, GOC:tb]
is_a: GO:0001672 ! regulation of chromatin assembly or disassembly
is_a: GO:0044087 ! regulation of cellular component biogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031497 ! chromatin assembly
relationship: regulates GO:0031497 ! chromatin assembly

[Term]
id: GO:0010848
name: regulation of chromatin disassembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chromatin disassembly. Chromatin disassembly is the controlled breakdown of chromatin from a higher order structure into its simpler subcomponents, DNA, histones, and other proteins." [GOC:dph, GOC:tb]
is_a: GO:0001672 ! regulation of chromatin assembly or disassembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031498 ! chromatin disassembly
relationship: regulates GO:0031498 ! chromatin disassembly

[Term]
id: GO:0010849
name: regulation of proton-transporting ATPase activity, rotational mechanism
namespace: biological_process
def: "Any process that modulates the rate of ATP hydrolysis by an ATPase. Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism." [GOC:dph, GOC:tb]
synonym: "regulation of hydrogen ion transporting ATPase activity, rotational mechanism" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of V-type ATPase activity" BROAD [GOC:dph, GOC:tb]
is_a: GO:0010155 ! regulation of proton transport
is_a: GO:0032412 ! regulation of ion transmembrane transporter activity
is_a: GO:0043462 ! regulation of ATPase activity
is_a: GO:1904062 ! regulation of cation transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0046961 ! proton-transporting ATPase activity, rotational mechanism
relationship: regulates GO:0046961 ! proton-transporting ATPase activity, rotational mechanism

[Term]
id: GO:0010850
name: regulation of blood pressure by chemoreceptor signaling pathway
namespace: biological_process
def: "A series of reactions within the cell that occur as a result of a single trigger reaction or compound interacting with a chemoreceptor resulting in a modulation of the force with which blood travels through the circulatory system. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions." [GOC:dph, GOC:tb]
synonym: "regulation of blood pressure by chemoreceptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0007165 ! signal transduction
is_a: GO:0008217 ! regulation of blood pressure

[Term]
id: GO:0010851
name: cyclase regulator activity
namespace: molecular_function
def: "Modulates the activity of an enzyme that catalyzes a ring closure reaction." [GOC:dph, GOC:tb]
is_a: GO:0030234 ! enzyme regulator activity
relationship: part_of GO:0031279 ! regulation of cyclase activity

[Term]
id: GO:0010852
name: cyclase inhibitor activity
namespace: molecular_function
def: "Decreases the activity of an enzyme that catalyzes a ring closure reaction." [GOC:dph, GOC:tb]
is_a: GO:0010851 ! cyclase regulator activity

[Term]
id: GO:0010853
name: cyclase activator activity
namespace: molecular_function
def: "Increases the activity of an enzyme that catalyzes a ring closure reaction." [GOC:dph, GOC:tb]
is_a: GO:0010851 ! cyclase regulator activity

[Term]
id: GO:0010854
name: adenylate cyclase regulator activity
namespace: molecular_function
def: "Modulates the activity of the enzyme that catalyzes the reaction: ATP = 3',5'-cyclic AMP + diphosphate." [GOC:dph, GOC:tb]
is_a: GO:0010851 ! cyclase regulator activity
relationship: has_part GO:0008179 ! adenylate cyclase binding

[Term]
id: GO:0010855
name: adenylate cyclase inhibitor activity
namespace: molecular_function
def: "Decreases the activity of the enzyme that catalyzes the reaction: ATP = 3',5'-cyclic AMP + diphosphate." [GOC:dph, GOC:tb]
is_a: GO:0010854 ! adenylate cyclase regulator activity

[Term]
id: GO:0010856
name: adenylate cyclase activator activity
namespace: molecular_function
def: "Increases the activity of the enzyme that catalyzes the reaction: ATP = 3',5'-cyclic AMP + diphosphate." [GOC:dph, GOC:tb]
is_a: GO:0010854 ! adenylate cyclase regulator activity

[Term]
id: GO:0010857
name: calcium-dependent protein kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP. This reaction requires the presence of calcium." [GOC:dph, GOC:tb]
is_a: GO:0004672 ! protein kinase activity

[Term]
id: GO:0010858
name: calcium-dependent protein kinase regulator activity
namespace: molecular_function
def: "Modulates the activity of a calcium-dependent protein kinase, an enzyme which phosphorylates a protein in a calcium-dependent manner." [GOC:dph, GOC:tb]
is_a: GO:0019887 ! protein kinase regulator activity

[Term]
id: GO:0010859
name: calcium-dependent cysteine-type endopeptidase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a calcium-dependent cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile in a calcium-dependent manner." [GOC:dph, GOC:tb]
is_a: GO:0004869 ! cysteine-type endopeptidase inhibitor activity

[Term]
id: GO:0010860
name: obsolete proteasome regulator activity
namespace: molecular_function
def: "OBSOLETE. Modulates the activity of the proteasome complex. The proteasome complex performs regulated ubiquitin-dependent cytosolic and nuclear proteolysis." [GOC:dph, GOC:tb]
comment: The term was made obsolete because 'proteasome' is not a valid molecular function term.
synonym: "proteasome regulator activity" EXACT []
is_obsolete: true
consider: GO:0061135
consider: GO:0061136

[Term]
id: GO:0010861
name: thyroid hormone receptor activator activity
namespace: molecular_function
def: "A receptor activator activity that binds to, thyroid hormone receptor in a ligand-dependent manner and enhances ligand-induced transcriptional activity of the receptor." [GOC:dph, GOC:mah, GOC:tb, PMID:9346901]
is_a: GO:0030546 ! receptor activator activity

[Term]
id: GO:0010862
name: positive regulation of pathway-restricted SMAD protein phosphorylation
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:dph, GOC:tb]
is_a: GO:0001934 ! positive regulation of protein phosphorylation
is_a: GO:0060393 ! regulation of pathway-restricted SMAD protein phosphorylation
is_a: GO:0090100 ! positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060389 ! pathway-restricted SMAD protein phosphorylation
relationship: positively_regulates GO:0060389 ! pathway-restricted SMAD protein phosphorylation

[Term]
id: GO:0010863
name: positive regulation of phospholipase C activity
namespace: biological_process
def: "Any process that increases the rate of phospholipase C activity." [GOC:dph, GOC:tb]
is_a: GO:0010518 ! positive regulation of phospholipase activity
is_a: GO:1900274 ! regulation of phospholipase C activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004629 ! phospholipase C activity
relationship: positively_regulates GO:0004629 ! phospholipase C activity

[Term]
id: GO:0010864
name: positive regulation of protein histidine kinase activity
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of protein histidine kinase activity." [GOC:dph, GOC:tb]
is_a: GO:0032110 ! regulation of protein histidine kinase activity
is_a: GO:0045860 ! positive regulation of protein kinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004673 ! protein histidine kinase activity
relationship: positively_regulates GO:0004673 ! protein histidine kinase activity

[Term]
id: GO:0010865
name: stipule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the stipule over time, from its formation to the mature structure. A stipule is one of (usually) a pair of appendages at the bases of leaves in many broad-leaved angiosperms." [GOC:tb]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048366 ! leaf development

[Term]
id: GO:0010866
name: regulation of triglyceride biosynthetic process
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol." [GOC:BHF, GOC:tb]
synonym: "regulation of triacylglycerol biosynthetic process" EXACT [GOC:mah]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0046890 ! regulation of lipid biosynthetic process
is_a: GO:0090207 ! regulation of triglyceride metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019432 ! triglyceride biosynthetic process
relationship: regulates GO:0019432 ! triglyceride biosynthetic process

[Term]
id: GO:0010867
name: positive regulation of triglyceride biosynthetic process
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol." [GOC:BHF, GOC:tb]
synonym: "positive regulation of triacylglycerol biosynthetic process" EXACT [GOC:mah]
is_a: GO:0010866 ! regulation of triglyceride biosynthetic process
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0046889 ! positive regulation of lipid biosynthetic process
is_a: GO:0090208 ! positive regulation of triglyceride metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0019432 ! triglyceride biosynthetic process
relationship: positively_regulates GO:0019432 ! triglyceride biosynthetic process

[Term]
id: GO:0010868
name: negative regulation of triglyceride biosynthetic process
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol." [GOC:BHF, GOC:tb]
synonym: "negative regulation of triacylglycerol biosynthetic process" EXACT [GOC:mah]
is_a: GO:0010866 ! regulation of triglyceride biosynthetic process
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0051055 ! negative regulation of lipid biosynthetic process
is_a: GO:0090209 ! negative regulation of triglyceride metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019432 ! triglyceride biosynthetic process
relationship: negatively_regulates GO:0019432 ! triglyceride biosynthetic process

[Term]
id: GO:0010869
name: regulation of receptor biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency or rate of receptor biosynthesis. Receptor biosynthesis is the collection of chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:BHF, GOC:tb]
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
is_a: GO:0031323 ! regulation of cellular metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032800 ! receptor biosynthetic process
relationship: regulates GO:0032800 ! receptor biosynthetic process

[Term]
id: GO:0010870
name: positive regulation of receptor biosynthetic process
namespace: biological_process
def: "Any process that increases the frequency or rate of receptor biosynthesis. Receptor biosynthesis is the collection of chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:BHF, GOC:tb]
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0010869 ! regulation of receptor biosynthetic process
is_a: GO:0031325 ! positive regulation of cellular metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032800 ! receptor biosynthetic process
relationship: positively_regulates GO:0032800 ! receptor biosynthetic process

[Term]
id: GO:0010871
name: negative regulation of receptor biosynthetic process
namespace: biological_process
def: "Any process that decreases the frequency or rate of receptor biosynthesis. Receptor biosynthesis is the collection of chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:BHF, GOC:tb]
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
is_a: GO:0010869 ! regulation of receptor biosynthetic process
is_a: GO:0031324 ! negative regulation of cellular metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032800 ! receptor biosynthetic process
relationship: negatively_regulates GO:0032800 ! receptor biosynthetic process

[Term]
id: GO:0010872
name: regulation of cholesterol esterification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cholesterol esterification. Cholesterol esterification is the lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and cholesterol. In the blood this process is associated with the conversion of free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle." [GOC:dph, GOC:tb]
is_a: GO:0019218 ! regulation of steroid metabolic process
is_a: GO:0031323 ! regulation of cellular metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034435 ! cholesterol esterification
relationship: regulates GO:0034435 ! cholesterol esterification

[Term]
id: GO:0010873
name: positive regulation of cholesterol esterification
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of cholesterol esterification. Cholesterol esterification is the lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and cholesterol. In the blood this process is associated with the conversion of free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010872 ! regulation of cholesterol esterification
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0045940 ! positive regulation of steroid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034435 ! cholesterol esterification
relationship: positively_regulates GO:0034435 ! cholesterol esterification

[Term]
id: GO:0010874
name: regulation of cholesterol efflux
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0032374 ! regulation of cholesterol transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0033344 ! cholesterol efflux
relationship: regulates GO:0033344 ! cholesterol efflux

[Term]
id: GO:0010875
name: positive regulation of cholesterol efflux
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010874 ! regulation of cholesterol efflux
is_a: GO:0032376 ! positive regulation of cholesterol transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0033344 ! cholesterol efflux
relationship: positively_regulates GO:0033344 ! cholesterol efflux

[Term]
id: GO:0010876
name: lipid localization
namespace: biological_process
def: "Any process in which a lipid is transported to, or maintained in, a specific location." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "lipid localisation" EXACT [GOC:mah]
is_a: GO:0033036 ! macromolecule localization

[Term]
id: GO:0010877
name: lipid transport involved in lipid storage
namespace: biological_process
def: "The directed movement of lipids into cells that is part of their accumulation and maintenance." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0006869 ! lipid transport
intersection_of: GO:0006869 ! lipid transport
intersection_of: part_of GO:0019915 ! lipid storage
relationship: part_of GO:0019915 ! lipid storage

[Term]
id: GO:0010878
name: cholesterol storage
namespace: biological_process
def: "The accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "cholesterol sequestration" NARROW [GOC:dph, GOC:tb]
synonym: "sequestration of cholesterol" NARROW [GOC:dph, GOC:tb]
is_a: GO:0019915 ! lipid storage

[Term]
id: GO:0010879
name: cholesterol transport involved in cholesterol storage
namespace: biological_process
def: "The directed movement of cholesterol into cells that is part of their accumulation and maintenance." [GOC:dph, GOC:tb]
is_a: GO:0010877 ! lipid transport involved in lipid storage
is_a: GO:0030301 ! cholesterol transport
intersection_of: GO:0030301 ! cholesterol transport
intersection_of: part_of GO:0010878 ! cholesterol storage
relationship: part_of GO:0010878 ! cholesterol storage

[Term]
id: GO:0010880
name: regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of release of sequestered calcium ion into cytosol by the sarcoplasmic reticulum, the process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0051279 ! regulation of release of sequestered calcium ion into cytosol
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0014808 ! release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
relationship: regulates GO:0014808 ! release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

[Term]
id: GO:0010881
name: regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010880 ! regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
is_a: GO:0010882 ! regulation of cardiac muscle contraction by calcium ion signaling

[Term]
id: GO:0010882
name: regulation of cardiac muscle contraction by calcium ion signaling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac muscle contraction by changing the calcium ion signals that trigger contraction." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "regulation of cardiac muscle contraction by calcium ion signalling" EXACT [GOC:mah]
is_a: GO:0019722 ! calcium-mediated signaling
is_a: GO:0055117 ! regulation of cardiac muscle contraction
intersection_of: GO:0019722 ! calcium-mediated signaling
intersection_of: regulates GO:0060048 ! cardiac muscle contraction
relationship: regulates GO:0060048 ! cardiac muscle contraction

[Term]
id: GO:0010883
name: regulation of lipid storage
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "regulation of lipid sequestration" NARROW [GOC:dph, GOC:tb]
is_a: GO:0032879 ! regulation of localization
is_a: GO:0065008 ! regulation of biological quality
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019915 ! lipid storage
relationship: regulates GO:0019915 ! lipid storage

[Term]
id: GO:0010884
name: positive regulation of lipid storage
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "positive regulation of lipid sequestration" NARROW [GOC:dph, GOC:tb]
is_a: GO:0010883 ! regulation of lipid storage
is_a: GO:0048518 ! positive regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0019915 ! lipid storage
relationship: positively_regulates GO:0019915 ! lipid storage

[Term]
id: GO:0010885
name: regulation of cholesterol storage
namespace: biological_process
def: "Any process that modulates the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010883 ! regulation of lipid storage
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010878 ! cholesterol storage
relationship: regulates GO:0010878 ! cholesterol storage

[Term]
id: GO:0010886
name: positive regulation of cholesterol storage
namespace: biological_process
def: "Any process that increases the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "positive regulation of cholesterol sequestration" NARROW [GOC:dph, GOC:tb]
is_a: GO:0010884 ! positive regulation of lipid storage
is_a: GO:0010885 ! regulation of cholesterol storage
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010878 ! cholesterol storage
relationship: positively_regulates GO:0010878 ! cholesterol storage

[Term]
id: GO:0010887
name: negative regulation of cholesterol storage
namespace: biological_process
def: "Any process that decreases the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "negative regulation of cholesterol sequestration" NARROW [GOC:dph, GOC:tb]
is_a: GO:0010885 ! regulation of cholesterol storage
is_a: GO:0010888 ! negative regulation of lipid storage
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010878 ! cholesterol storage
relationship: negatively_regulates GO:0010878 ! cholesterol storage

[Term]
id: GO:0010888
name: negative regulation of lipid storage
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010883 ! regulation of lipid storage
is_a: GO:0048519 ! negative regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019915 ! lipid storage
relationship: negatively_regulates GO:0019915 ! lipid storage

[Term]
id: GO:0010889
name: regulation of sequestering of triglyceride
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "regulation of sequestering of triacylglycerol" EXACT [GOC:mah]
synonym: "regulation of triacylglycerol sequestration" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010883 ! regulation of lipid storage
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030730 ! sequestering of triglyceride
relationship: regulates GO:0030730 ! sequestering of triglyceride

[Term]
id: GO:0010890
name: positive regulation of sequestering of triglyceride
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "positive regulation of sequestering of triacylglycerol" EXACT [GOC:mah]
synonym: "positive regulation of triglyceride sequestration" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010884 ! positive regulation of lipid storage
is_a: GO:0010889 ! regulation of sequestering of triglyceride
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030730 ! sequestering of triglyceride
relationship: positively_regulates GO:0030730 ! sequestering of triglyceride

[Term]
id: GO:0010891
name: negative regulation of sequestering of triglyceride
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "negative regulation of sequestering of triacylglycerol" EXACT [GOC:mah]
synonym: "negative regulation of triglyceride sequestration" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010888 ! negative regulation of lipid storage
is_a: GO:0010889 ! regulation of sequestering of triglyceride
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030730 ! sequestering of triglyceride
relationship: negatively_regulates GO:0030730 ! sequestering of triglyceride

[Term]
id: GO:0010892
name: positive regulation of mitochondrial translation in response to stress
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitochondrial translation as a result of a stimulus indicating the organism is under stress." [GOC:dph, GOC:jp, GOC:tb, PMID:8830768]
is_a: GO:0032056 ! positive regulation of translation in response to stress
is_a: GO:0070131 ! positive regulation of mitochondrial translation

[Term]
id: GO:0010893
name: positive regulation of steroid biosynthetic process
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:tb]
is_a: GO:0045940 ! positive regulation of steroid metabolic process
is_a: GO:0046889 ! positive regulation of lipid biosynthetic process
is_a: GO:0050810 ! regulation of steroid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006694 ! steroid biosynthetic process
relationship: positively_regulates GO:0006694 ! steroid biosynthetic process

[Term]
id: GO:0010894
name: negative regulation of steroid biosynthetic process
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:BHF, GOC:tb]
is_a: GO:0045939 ! negative regulation of steroid metabolic process
is_a: GO:0050810 ! regulation of steroid biosynthetic process
is_a: GO:0051055 ! negative regulation of lipid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006694 ! steroid biosynthetic process
relationship: negatively_regulates GO:0006694 ! steroid biosynthetic process

[Term]
id: GO:0010895
name: negative regulation of ergosterol biosynthetic process
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ergosterol." [GOC:tb]
is_a: GO:0010894 ! negative regulation of steroid biosynthetic process
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0032443 ! regulation of ergosterol biosynthetic process
is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006696 ! ergosterol biosynthetic process
relationship: negatively_regulates GO:0006696 ! ergosterol biosynthetic process

[Term]
id: GO:0010896
name: regulation of triglyceride catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride." [GOC:rn, GOC:tb]
synonym: "regulation of triacylglycerol catabolic process" EXACT [GOC:mah]
is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:0050994 ! regulation of lipid catabolic process
is_a: GO:0090207 ! regulation of triglyceride metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019433 ! triglyceride catabolic process
relationship: regulates GO:0019433 ! triglyceride catabolic process

[Term]
id: GO:0010897
name: negative regulation of triglyceride catabolic process
namespace: biological_process
def: "Any process that decreases the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride." [GOC:rn, GOC:tb]
synonym: "negative regulation of triacylglycerol catabolic process" EXACT [GOC:mah]
is_a: GO:0010896 ! regulation of triglyceride catabolic process
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:0050995 ! negative regulation of lipid catabolic process
is_a: GO:0090209 ! negative regulation of triglyceride metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019433 ! triglyceride catabolic process
relationship: negatively_regulates GO:0019433 ! triglyceride catabolic process

[Term]
id: GO:0010898
name: positive regulation of triglyceride catabolic process
namespace: biological_process
def: "Any process that increases the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride." [GOC:rn, GOC:tb]
synonym: "positive regulation of triacylglycerol catabolic process" EXACT [GOC:mah]
is_a: GO:0010896 ! regulation of triglyceride catabolic process
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:0050996 ! positive regulation of lipid catabolic process
is_a: GO:0090208 ! positive regulation of triglyceride metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0019433 ! triglyceride catabolic process
relationship: positively_regulates GO:0019433 ! triglyceride catabolic process

[Term]
id: GO:0010899
name: regulation of phosphatidylcholine catabolic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of phosphatidylcholine catabolism. Phosphatidylcholine catabolic processes are the chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:BHF, GOC:tb]
is_a: GO:0033238 ! regulation of cellular amine metabolic process
is_a: GO:0060696 ! regulation of phospholipid catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034638 ! phosphatidylcholine catabolic process
relationship: regulates GO:0034638 ! phosphatidylcholine catabolic process

[Term]
id: GO:0010900
name: negative regulation of phosphatidylcholine catabolic process
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of phosphatidylcholine catabolism. Phosphatidylcholine catabolic processes are the chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:BHF, GOC:tb]
is_a: GO:0010899 ! regulation of phosphatidylcholine catabolic process
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:0033239 ! negative regulation of cellular amine metabolic process
is_a: GO:0050995 ! negative regulation of lipid catabolic process
is_a: GO:1903726 ! negative regulation of phospholipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034638 ! phosphatidylcholine catabolic process
relationship: negatively_regulates GO:0034638 ! phosphatidylcholine catabolic process

[Term]
id: GO:0010901
name: regulation of very-low-density lipoprotein particle remodeling
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of very-low-density lipoprotein particle remodeling. Very-low-density lipoprotein particle remodeling is the acquisition, loss or modification of a protein or lipid within a very-low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase or lipoprotein lipase and the subsequent loss of free fatty acid." [GOC:tb]
synonym: "regulation of VLDL remodeling" EXACT [GOC:tb]
is_a: GO:0051128 ! regulation of cellular component organization
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034372 ! very-low-density lipoprotein particle remodeling
relationship: regulates GO:0034372 ! very-low-density lipoprotein particle remodeling

[Term]
id: GO:0010902
name: positive regulation of very-low-density lipoprotein particle remodeling
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of very-low-density lipoprotein particle remodeling. Very-low-density lipoprotein particle remodeling is the acquisition, loss or modification of a protein or lipid within a very-low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase or lipoprotein lipase and the subsequent loss of free fatty acid." [GOC:tb]
synonym: "positive regulation of VLDL remodeling" EXACT [GOC:tb]
is_a: GO:0010901 ! regulation of very-low-density lipoprotein particle remodeling
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034372 ! very-low-density lipoprotein particle remodeling
relationship: positively_regulates GO:0034372 ! very-low-density lipoprotein particle remodeling

[Term]
id: GO:0010903
name: negative regulation of very-low-density lipoprotein particle remodeling
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of very-low-density lipoprotein particle remodeling. Very-low-density lipoprotein particle remodeling is the acquisition, loss or modification of a protein or lipid within a very-low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase or lipoprotein lipase and the subsequent loss of free fatty acid." [GOC:tb]
synonym: "negative regulation of VLDL remodeling" EXACT [GOC:tb]
is_a: GO:0010901 ! regulation of very-low-density lipoprotein particle remodeling
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034372 ! very-low-density lipoprotein particle remodeling
relationship: negatively_regulates GO:0034372 ! very-low-density lipoprotein particle remodeling

[Term]
id: GO:0010904
name: regulation of UDP-glucose catabolic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of UDP-glucose catabolism. UDP-glucose catabolic processes are the chemical reactions and pathways resulting in the breakdown of UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate." [GOC:BHF, GOC:tb]
synonym: "regulation of UDP-glucose catabolism" EXACT [GOC:tb]
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0010906 ! regulation of glucose metabolic process
is_a: GO:0030811 ! regulation of nucleotide catabolic process
is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006258 ! UDP-glucose catabolic process
relationship: regulates GO:0006258 ! UDP-glucose catabolic process

[Term]
id: GO:0010905
name: negative regulation of UDP-glucose catabolic process
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of UDP-glucose catabolism. UDP-glucose catabolic processes are the chemical reactions and pathways resulting in the breakdown of UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate." [GOC:BHF, GOC:tb]
synonym: "negative regulation of UDP-glucose catabolism" EXACT [GOC:tb]
is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process
is_a: GO:0010904 ! regulation of UDP-glucose catabolic process
is_a: GO:0030812 ! negative regulation of nucleotide catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006258 ! UDP-glucose catabolic process
relationship: negatively_regulates GO:0006258 ! UDP-glucose catabolic process

[Term]
id: GO:0010906
name: regulation of glucose metabolic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose." [GOC:BHF, GOC:tb]
synonym: "regulation of glucose metabolism" EXACT [GOC:tb]
is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006006 ! glucose metabolic process
relationship: regulates GO:0006006 ! glucose metabolic process

[Term]
id: GO:0010907
name: positive regulation of glucose metabolic process
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose." [GOC:BHF, GOC:tb]
synonym: "positive regulation of glucose metabolism" EXACT [GOC:tb]
is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process
is_a: GO:0010906 ! regulation of glucose metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006006 ! glucose metabolic process
relationship: positively_regulates GO:0006006 ! glucose metabolic process

[Term]
id: GO:0010908
name: regulation of heparan sulfate proteoglycan biosynthetic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of heparan sulfate proteoglycan biosynthesis. Heparan sulfate proteoglycan biosynthetic processes are the chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues." [GOC:dph, GOC:tb]
is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0015012 ! heparan sulfate proteoglycan biosynthetic process
relationship: regulates GO:0015012 ! heparan sulfate proteoglycan biosynthetic process

[Term]
id: GO:0010909
name: positive regulation of heparan sulfate proteoglycan biosynthetic process
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of heparan sulfate proteoglycan biosynthesis. Heparan sulfate proteoglycan biosynthetic processes are the chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues." [GOC:dph, GOC:tb]
is_a: GO:0010908 ! regulation of heparan sulfate proteoglycan biosynthetic process
is_a: GO:0051176 ! positive regulation of sulfur metabolic process
is_a: GO:1902730 ! positive regulation of proteoglycan biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0015012 ! heparan sulfate proteoglycan biosynthetic process
relationship: positively_regulates GO:0015012 ! heparan sulfate proteoglycan biosynthetic process

[Term]
id: GO:0010910
name: positive regulation of heparan sulfate proteoglycan biosynthesis by positive regulation of epimerase activity
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of heparan sulfate proteoglycan biosynthesis by an increase in epimerase activity. This epimerase activity catalyzes the reaction that converts D-glucuronate into its diastereoisomer in heparan sulfate." [GOC:dph, GOC:tb]
is_a: GO:0010909 ! positive regulation of heparan sulfate proteoglycan biosynthetic process
is_a: GO:0010912 ! positive regulation of isomerase activity

[Term]
id: GO:0010911
name: regulation of isomerase activity
namespace: biological_process
def: "Any process that modulates the activity of an isomerase. An isomerase catalyzes the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [GOC:dph, GOC:tb]
is_a: GO:0050790 ! regulation of catalytic activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016853 ! isomerase activity
relationship: regulates GO:0016853 ! isomerase activity

[Term]
id: GO:0010912
name: positive regulation of isomerase activity
namespace: biological_process
def: "Any process that increases the activity of an isomerase. An isomerase catalyzes the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [GOC:dph, GOC:tb]
is_a: GO:0010911 ! regulation of isomerase activity
is_a: GO:0043085 ! positive regulation of catalytic activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016853 ! isomerase activity
relationship: positively_regulates GO:0016853 ! isomerase activity

[Term]
id: GO:0010913
name: regulation of sterigmatocystin biosynthetic process
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of sterigmatocystin biosynthesis. Sterigmatocystin biosynthetic processes are the chemical reactions and pathways resulting in the formation of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds." [GOC:dph, GOC:tb]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045461 ! sterigmatocystin biosynthetic process
relationship: regulates GO:0045461 ! sterigmatocystin biosynthetic process

[Term]
id: GO:0010914
name: positive regulation of sterigmatocystin biosynthetic process
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of sterigmatocystin biosynthesis. Sterigmatocystin biosynthetic processes are the chemical reactions and pathways resulting in the formation of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds." [GOC:dph, GOC:tb]
is_a: GO:0010913 ! regulation of sterigmatocystin biosynthetic process
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045461 ! sterigmatocystin biosynthetic process
relationship: positively_regulates GO:0045461 ! sterigmatocystin biosynthetic process

[Term]
id: GO:0010915
name: regulation of very-low-density lipoprotein particle clearance
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of very-low-density lipoprotein particle clearance. Very-low-density lipoprotein particle clearance is the process in which a very-low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "regulation of VLDL clearance" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of VLDL particle clearance" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010984 ! regulation of lipoprotein particle clearance
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034447 ! very-low-density lipoprotein particle clearance
relationship: regulates GO:0034447 ! very-low-density lipoprotein particle clearance

[Term]
id: GO:0010916
name: negative regulation of very-low-density lipoprotein particle clearance
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of very-low-density lipoprotein particle clearance. Very-low-density lipoprotein particle clearance is the process in which a very-low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "negative regulation of VLDL clearance" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of VLDL particle clearance" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010915 ! regulation of very-low-density lipoprotein particle clearance
is_a: GO:0010985 ! negative regulation of lipoprotein particle clearance
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034447 ! very-low-density lipoprotein particle clearance
relationship: negatively_regulates GO:0034447 ! very-low-density lipoprotein particle clearance

[Term]
id: GO:0010917
name: negative regulation of mitochondrial membrane potential
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or extent of a mitochondrial membrane potential, the electric potential existing across any mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:dph, GOC:tb]
synonym: "reduction of mitochondrial membrane potential" EXACT [GOC:rph]
is_a: GO:0045837 ! negative regulation of membrane potential
is_a: GO:0051881 ! regulation of mitochondrial membrane potential

[Term]
id: GO:0010918
name: positive regulation of mitochondrial membrane potential
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment or extent of a mitochondrial membrane potential, the electric potential existing across any mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:dph, GOC:tb]
synonym: "elevation of mitochondrial membrane potential" EXACT [GOC:rph]
is_a: GO:0045838 ! positive regulation of membrane potential
is_a: GO:0051881 ! regulation of mitochondrial membrane potential

[Term]
id: GO:0010919
name: regulation of inositol phosphate biosynthetic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of inositol phosphate biosynthesis. Inositol phosphate biosynthetic processes are the chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "regulation of inositol phosphate biosynthesis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process
is_a: GO:0019220 ! regulation of phosphate metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process
is_a: GO:1902930 ! regulation of alcohol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032958 ! inositol phosphate biosynthetic process
relationship: regulates GO:0032958 ! inositol phosphate biosynthetic process

[Term]
id: GO:0010920
name: negative regulation of inositol phosphate biosynthetic process
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of inositol phosphate biosynthesis. Inositol phosphate biosynthetic processes are the chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [GOC:dph, GOC:tb]
synonym: "negative regulation of inositol phosphate biosynthesis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process
is_a: GO:0010919 ! regulation of inositol phosphate biosynthetic process
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0045936 ! negative regulation of phosphate metabolic process
is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032958 ! inositol phosphate biosynthetic process
relationship: negatively_regulates GO:0032958 ! inositol phosphate biosynthetic process

[Term]
id: GO:0010921
name: regulation of phosphatase activity
namespace: biological_process
def: "Any process that modulates the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0035304 ! regulation of protein dephosphorylation
is_a: GO:0051336 ! regulation of hydrolase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016791 ! phosphatase activity
relationship: regulates GO:0016791 ! phosphatase activity

[Term]
id: GO:0010922
name: positive regulation of phosphatase activity
namespace: biological_process
def: "Any process that increases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010921 ! regulation of phosphatase activity
is_a: GO:0035307 ! positive regulation of protein dephosphorylation
is_a: GO:0051345 ! positive regulation of hydrolase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016791 ! phosphatase activity
relationship: positively_regulates GO:0016791 ! phosphatase activity

[Term]
id: GO:0010923
name: negative regulation of phosphatase activity
namespace: biological_process
def: "Any process that decreases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010921 ! regulation of phosphatase activity
is_a: GO:0035308 ! negative regulation of protein dephosphorylation
is_a: GO:0051346 ! negative regulation of hydrolase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016791 ! phosphatase activity
relationship: negatively_regulates GO:0016791 ! phosphatase activity

[Term]
id: GO:0010924
name: regulation of inositol-polyphosphate 5-phosphatase activity
namespace: biological_process
def: "Any process that modulates the rate or frequency of inositol-polyphosphate 5-phosphatase activity, the catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010921 ! regulation of phosphatase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004445 ! inositol-polyphosphate 5-phosphatase activity
relationship: regulates GO:0004445 ! inositol-polyphosphate 5-phosphatase activity

[Term]
id: GO:0010925
name: positive regulation of inositol-polyphosphate 5-phosphatase activity
namespace: biological_process
def: "Any process that increases the rate or frequency of inositol-polyphosphate 5-phosphatase activity, the catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010922 ! positive regulation of phosphatase activity
is_a: GO:0010924 ! regulation of inositol-polyphosphate 5-phosphatase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004445 ! inositol-polyphosphate 5-phosphatase activity
relationship: positively_regulates GO:0004445 ! inositol-polyphosphate 5-phosphatase activity

[Term]
id: GO:0010926
name: obsolete anatomical structure formation
namespace: biological_process
def: "OBSOLETE. The process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structure is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:tb]
comment: The reason for obsoletion is that the term is confusing - it sounds developmental and has a developmental sounding def, but it is not a child of developmental process and its children included 'cellular component assembly'. The term was created to group together 'cellular component assembly' and 'anatomical structure formation involved in morphogenesis', but we no longer feel that this grouping is useful.
synonym: "anatomical structure formation" EXACT []
is_obsolete: true
consider: GO:0022607
consider: GO:0048646

[Term]
id: GO:0010927
name: cellular component assembly involved in morphogenesis
namespace: biological_process
def: "The cellular component assembly that is part of the initial shaping of the component during its developmental progression." [GOC:dph, GOC:tb]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: part_of GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0032989 ! cellular component morphogenesis

[Term]
id: GO:0010928
name: regulation of auxin mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of auxin mediated signaling pathway. Auxin mediated signaling pathway is the series of molecular signals generated in response to detection of auxin." [GOC:dph, GOC:tb]
synonym: "regulation of auxin mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0009966 ! regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009734 ! auxin-activated signaling pathway
relationship: regulates GO:0009734 ! auxin-activated signaling pathway

[Term]
id: GO:0010929
name: positive regulation of auxin mediated signaling pathway
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of auxin mediated signaling pathway. Auxin mediated signaling pathway is the series of molecular signals generated in response to detection of auxin." [GOC:dph, GOC:tb]
synonym: "positive regulation of auxin mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0010928 ! regulation of auxin mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009734 ! auxin-activated signaling pathway
relationship: positively_regulates GO:0009734 ! auxin-activated signaling pathway

[Term]
id: GO:0010930
name: negative regulation of auxin mediated signaling pathway
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of auxin mediated signaling pathway. Auxin mediated signaling pathway is the series of molecular signals generated in response to detection of auxin." [GOC:dph, GOC:tb]
synonym: "negative regulation of auxin mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0010928 ! regulation of auxin mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009734 ! auxin-activated signaling pathway
relationship: negatively_regulates GO:0009734 ! auxin-activated signaling pathway

[Term]
id: GO:0010931
name: macrophage tolerance induction
namespace: biological_process
def: "A process involving any mechanism for tolerance induction in macrophages." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0002507 ! tolerance induction

[Term]
id: GO:0010932
name: regulation of macrophage tolerance induction
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of B cell tolerance induction." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0002643 ! regulation of tolerance induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010931 ! macrophage tolerance induction
relationship: regulates GO:0010931 ! macrophage tolerance induction

[Term]
id: GO:0010933
name: positive regulation of macrophage tolerance induction
namespace: biological_process
def: "Any process that increases the frequency, rate, or extent of B cell tolerance induction." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0002645 ! positive regulation of tolerance induction
is_a: GO:0010932 ! regulation of macrophage tolerance induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010931 ! macrophage tolerance induction
relationship: positively_regulates GO:0010931 ! macrophage tolerance induction

[Term]
id: GO:0010934
name: macrophage cytokine production
namespace: biological_process
def: "The appearance of a macrophage cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]
is_a: GO:0061082 ! myeloid leukocyte cytokine production

[Term]
id: GO:0010935
name: regulation of macrophage cytokine production
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:rl]
is_a: GO:0002718 ! regulation of cytokine production involved in immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010934 ! macrophage cytokine production
relationship: regulates GO:0010934 ! macrophage cytokine production

[Term]
id: GO:0010936
name: negative regulation of macrophage cytokine production
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:rl]
is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response
is_a: GO:0010935 ! regulation of macrophage cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010934 ! macrophage cytokine production
relationship: negatively_regulates GO:0010934 ! macrophage cytokine production

[Term]
id: GO:0010937
name: regulation of cytoplasmic microtubule depolymerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cytoplasmic microtubule depolymerization." [GOC:dph, GOC:tb]
is_a: GO:0031114 ! regulation of microtubule depolymerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010938 ! cytoplasmic microtubule depolymerization
relationship: regulates GO:0010938 ! cytoplasmic microtubule depolymerization

[Term]
id: GO:0010938
name: cytoplasmic microtubule depolymerization
namespace: biological_process
def: "The removal of tubulin heterodimers from one or both ends of a cytoplasmic microtubule." [GOC:dph, GOC:tb]
is_a: GO:0007019 ! microtubule depolymerization
is_a: GO:0031122 ! cytoplasmic microtubule organization
intersection_of: GO:0007019 ! microtubule depolymerization
intersection_of: occurs_in GO:0005737 ! cytoplasm
relationship: occurs_in GO:0005737 ! cytoplasm

[Term]
id: GO:0010939
name: regulation of necrotic cell death
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents." [PMID:16507998]
is_a: GO:0010941 ! regulation of cell death
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070265 ! necrotic cell death
relationship: regulates GO:0070265 ! necrotic cell death

[Term]
id: GO:0010940
name: positive regulation of necrotic cell death
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents." [PMID:16507998]
is_a: GO:0010939 ! regulation of necrotic cell death
is_a: GO:0010942 ! positive regulation of cell death
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070265 ! necrotic cell death
relationship: positively_regulates GO:0070265 ! necrotic cell death

[Term]
id: GO:0010941
name: regulation of cell death
namespace: biological_process
def: "Any process that modulates the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GOC:dph, GOC:tb]
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008219 ! cell death
relationship: regulates GO:0008219 ! cell death

[Term]
id: GO:0010942
name: positive regulation of cell death
namespace: biological_process
def: "Any process that increases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GOC:dph, GOC:tb]
is_a: GO:0010941 ! regulation of cell death
is_a: GO:0048522 ! positive regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008219 ! cell death
relationship: positively_regulates GO:0008219 ! cell death

[Term]
id: GO:0010943
name: NADPH pyrophosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADPH + H2O = NMNH + ADP." [GOC:tb]
is_a: GO:0004551 ! nucleotide diphosphatase activity

[Term]
id: GO:0010944
name: negative regulation of transcription by competitive promoter binding
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves direct competition for interaction with a promoter binding site." [GOC:tb]
is_a: GO:0045892 ! negative regulation of transcription, DNA-templated

[Term]
id: GO:0010945
name: CoA pyrophosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: coenzyme A + H2O = 3',5'-ADP + 4'-phosphopantetheine." [GOC:tb]
is_a: GO:0016462 ! pyrophosphatase activity
created_by: tanyaberardini
creation_date: 2009-04-22T02:06:40Z

[Term]
id: GO:0010946
name: regulation of meiotic joint molecule formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of meiotic joint molecule formation. Meiotic joint molecule formation is the conversion of the paired broken DNA and homologous duplex DNA into a four-stranded branched intermediate, known as a joint molecule, formed during meiotic recombination." [GOC:dph, GOC:tb]
is_a: GO:0010520 ! regulation of reciprocal meiotic recombination
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000709 ! meiotic joint molecule formation
relationship: regulates GO:0000709 ! meiotic joint molecule formation
created_by: tanyaberardini
creation_date: 2009-04-27T09:46:23Z

[Term]
id: GO:0010947
name: negative regulation of meiotic joint molecule formation
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of meiotic joint molecule formation. Meiotic joint molecule formation is the conversion of the paired broken DNA and homologous duplex DNA into a four-stranded branched intermediate, known as a joint molecule, formed during meiotic recombination." [GOC:dph, GOC:tb]
is_a: GO:0010946 ! regulation of meiotic joint molecule formation
is_a: GO:0045128 ! negative regulation of reciprocal meiotic recombination
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000709 ! meiotic joint molecule formation
relationship: negatively_regulates GO:0000709 ! meiotic joint molecule formation
created_by: tanyaberardini
creation_date: 2009-04-27T09:48:53Z

[Term]
id: GO:0010948
name: negative regulation of cell cycle process
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb]
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0045786 ! negative regulation of cell cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0022402 ! cell cycle process
relationship: negatively_regulates GO:0022402 ! cell cycle process
created_by: tanyaberardini
creation_date: 2009-04-27T09:53:22Z

[Term]
id: GO:0010949
name: negative regulation of intestinal phytosterol absorption
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of phytosterols into the blood by absorption from the small intestine." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0032372 ! negative regulation of sterol transport
is_a: GO:1904730 ! negative regulation of intestinal lipid absorption
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060752 ! intestinal phytosterol absorption
relationship: negatively_regulates GO:0060752 ! intestinal phytosterol absorption
created_by: tanyaberardini
creation_date: 2009-04-27T11:02:06Z

[Term]
id: GO:0010950
name: positive regulation of endopeptidase activity
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb]
is_a: GO:0010952 ! positive regulation of peptidase activity
is_a: GO:0052548 ! regulation of endopeptidase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004175 ! endopeptidase activity
relationship: positively_regulates GO:0004175 ! endopeptidase activity
created_by: tanyaberardini
creation_date: 2009-04-27T11:45:39Z

[Term]
id: GO:0010951
name: negative regulation of endopeptidase activity
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb]
subset: goslim_chembl
is_a: GO:0010466 ! negative regulation of peptidase activity
is_a: GO:0052548 ! regulation of endopeptidase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004175 ! endopeptidase activity
relationship: negatively_regulates GO:0004175 ! endopeptidase activity
created_by: tanyaberardini
creation_date: 2009-04-27T11:47:01Z

[Term]
id: GO:0010952
name: positive regulation of peptidase activity
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb]
is_a: GO:0045862 ! positive regulation of proteolysis
is_a: GO:0051345 ! positive regulation of hydrolase activity
is_a: GO:0052547 ! regulation of peptidase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008233 ! peptidase activity
relationship: positively_regulates GO:0008233 ! peptidase activity
created_by: tanyaberardini
creation_date: 2009-04-27T11:54:32Z

[Term]
id: GO:0010954
name: positive regulation of protein processing
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of protein maturation by peptide bond cleavage." [GOC:dph, GOC:mah, GOC:tb]
synonym: "positive regulation of protein maturation by peptide bond cleavage" EXACT [GOC:bf]
is_a: GO:0045862 ! positive regulation of proteolysis
is_a: GO:0070613 ! regulation of protein processing
is_a: GO:1903319 ! positive regulation of protein maturation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016485 ! protein processing
relationship: positively_regulates GO:0016485 ! protein processing
created_by: tanyaberardini
creation_date: 2009-04-27T12:09:13Z

[Term]
id: GO:0010955
name: negative regulation of protein processing
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of protein maturation by peptide bond cleavage." [GOC:dph, GOC:mah, GOC:tb]
synonym: "negative regulation of protein maturation by peptide bond cleavage" EXACT [GOC:bf]
is_a: GO:0045861 ! negative regulation of proteolysis
is_a: GO:0070613 ! regulation of protein processing
is_a: GO:1903318 ! negative regulation of protein maturation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016485 ! protein processing
relationship: negatively_regulates GO:0016485 ! protein processing
created_by: tanyaberardini
creation_date: 2009-04-27T12:10:19Z

[Term]
id: GO:0010956
name: negative regulation of calcidiol 1-monooxygenase activity
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of calcidiol 1-monooxygenase activity. Calcidiol 1-monooxygenase activity is the catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010957 ! negative regulation of vitamin D biosynthetic process
is_a: GO:0032769 ! negative regulation of monooxygenase activity
is_a: GO:0060558 ! regulation of calcidiol 1-monooxygenase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004498 ! calcidiol 1-monooxygenase activity
relationship: negatively_regulates GO:0004498 ! calcidiol 1-monooxygenase activity
created_by: tanyaberardini
creation_date: 2009-05-06T11:21:34Z

[Term]
id: GO:0010957
name: negative regulation of vitamin D biosynthetic process
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of a vitamin D biosynthetic process. Vitamin D biosynthesis is the chemical reactions and pathways resulting in the formation of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010894 ! negative regulation of steroid biosynthetic process
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0046137 ! negative regulation of vitamin metabolic process
is_a: GO:0060556 ! regulation of vitamin D biosynthetic process
is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042368 ! vitamin D biosynthetic process
relationship: negatively_regulates GO:0042368 ! vitamin D biosynthetic process
created_by: tanyaberardini
creation_date: 2009-05-06T11:25:12Z

[Term]
id: GO:0010958
name: regulation of amino acid import
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of amino acid import. Amino acid import is the directed movement of amino acids into a cell or organelle." [GOC:dph, GOC:tb]
is_a: GO:0051955 ! regulation of amino acid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043090 ! amino acid import
relationship: regulates GO:0043090 ! amino acid import
created_by: tanyaberardini
creation_date: 2009-05-06T11:33:12Z

[Term]
id: GO:0010959
name: regulation of metal ion transport
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of metal ion transport. Metal ion transport is the directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb]
is_a: GO:0043269 ! regulation of ion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030001 ! metal ion transport
relationship: regulates GO:0030001 ! metal ion transport
created_by: tanyaberardini
creation_date: 2009-05-06T11:40:55Z

[Term]
id: GO:0010960
name: magnesium ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of magnesium ions within an organism or cell." [GOC:dph, GOC:tb]
is_a: GO:0055065 ! metal ion homeostasis
is_a: GO:0072507 ! divalent inorganic cation homeostasis
created_by: tanyaberardini
creation_date: 2009-05-06T11:47:17Z

[Term]
id: GO:0010961
name: cellular magnesium ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of magnesium ions at the level of a cell." [GOC:dph, GOC:tb]
is_a: GO:0006875 ! cellular metal ion homeostasis
is_a: GO:0010960 ! magnesium ion homeostasis
is_a: GO:0072503 ! cellular divalent inorganic cation homeostasis
created_by: tanyaberardini
creation_date: 2009-05-06T11:48:45Z

[Term]
id: GO:0010962
name: regulation of glucan biosynthetic process
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of glucan biosynthesis. Glucan biosynthetic processes are the chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues." [GOC:dph, GOC:tb]
is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process
is_a: GO:0032885 ! regulation of polysaccharide biosynthetic process
is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009250 ! glucan biosynthetic process
relationship: regulates GO:0009250 ! glucan biosynthetic process
created_by: tanyaberardini
creation_date: 2009-05-11T12:17:53Z

[Term]
id: GO:0010963
name: regulation of L-arginine import
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of L-arginine import. L-arginine import is the directed movement of L-arginine, the L-enantiomer of 2-amino-5-guanidinopentanoic acid, into a cell or organelle." [GOC:dph, GOC:tb]
is_a: GO:0010958 ! regulation of amino acid import
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043091 ! L-arginine import
relationship: regulates GO:0043091 ! L-arginine import
created_by: tanyaberardini
creation_date: 2009-05-20T11:20:18Z

[Term]
id: GO:0010964
name: regulation of chromatin silencing by small RNA
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chromatin silencing by small RNA. Chromatin silencing by small RNA is the repression of transcription by conversion of large regions of DNA into heterochromatin, directed by small RNAs sharing sequence identity to the repressed region." [GOC:dph, GOC:tb]
is_a: GO:0031935 ! regulation of chromatin silencing
is_a: GO:0060966 ! regulation of gene silencing by RNA
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031048 ! chromatin silencing by small RNA
relationship: regulates GO:0031048 ! chromatin silencing by small RNA
created_by: tanyaberardini
creation_date: 2009-05-20T11:25:42Z

[Term]
id: GO:0010965
name: regulation of mitotic sister chromatid separation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitotic sister chromatid separation. Mitotic sister chromatid separation is the process in which sister chromatids are physically detached from each other during mitosis." [GOC:dph, GOC:tb]
is_a: GO:0033047 ! regulation of mitotic sister chromatid segregation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051306 ! mitotic sister chromatid separation
relationship: regulates GO:0051306 ! mitotic sister chromatid separation
created_by: tanyaberardini
creation_date: 2009-05-20T11:39:07Z

[Term]
id: GO:0010966
name: regulation of phosphate transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phosphate transport. Phosphate transport is the directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb]
is_a: GO:0044070 ! regulation of anion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006817 ! phosphate ion transport
relationship: regulates GO:0006817 ! phosphate ion transport
created_by: tanyaberardini
creation_date: 2009-05-20T11:42:50Z

[Term]
id: GO:0010967
name: regulation of polyamine biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of polyamine biosynthesis. Polyamine biosynthesis is the chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups." [GOC:dph, GOC:tb]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0033238 ! regulation of cellular amine metabolic process
is_a: GO:0080090 ! regulation of primary metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006596 ! polyamine biosynthetic process
relationship: regulates GO:0006596 ! polyamine biosynthetic process
created_by: tanyaberardini
creation_date: 2009-05-20T11:45:37Z

[Term]
id: GO:0010968
name: regulation of microtubule nucleation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell." [GOC:dph, GOC:tb]
is_a: GO:0031113 ! regulation of microtubule polymerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007020 ! microtubule nucleation
relationship: regulates GO:0007020 ! microtubule nucleation
created_by: tanyaberardini
creation_date: 2009-05-20T11:51:21Z

[Term]
id: GO:0010969
name: regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pheromone-dependent signal transduction during conjugation with cellular fusion, a signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion." [GOC:dph, GOC:tb]
is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:0060238 ! regulation of signal transduction involved in conjugation with cellular fusion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000750 ! pheromone-dependent signal transduction involved in conjugation with cellular fusion
relationship: regulates GO:0000750 ! pheromone-dependent signal transduction involved in conjugation with cellular fusion
created_by: tanyaberardini
creation_date: 2009-05-20T11:54:57Z

[Term]
id: GO:0010970
name: establishment of localization by movement along microtubule
namespace: biological_process
def: "The movement of organelles or other particles from one location in the cell to another along microtubules." [GOC:dph, GOC:mah, GOC:tb]
synonym: "microtubule-based transport" EXACT []
synonym: "momvement along microtubule" EXACT []
is_a: GO:0007018 ! microtubule-based movement
is_a: GO:0051234 ! establishment of localization
is_a: GO:1902578 ! single-organism localization
created_by: tanyaberardini
creation_date: 2009-05-27T10:56:08Z

[Term]
id: GO:0010971
name: positive regulation of G2/M transition of mitotic cell cycle
namespace: biological_process
def: "Any process that increases the rate or extent of progression from G2 phase to M phase of the mitotic cell cycle." [GOC:dph, GOC:mtg_cell_cycle, GOC:tb]
synonym: "positive regulation of mitotic entry" EXACT [GOC:mah]
is_a: GO:0010389 ! regulation of G2/M transition of mitotic cell cycle
is_a: GO:1901992 ! positive regulation of mitotic cell cycle phase transition
is_a: GO:1902751 ! positive regulation of cell cycle G2/M phase transition
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000086 ! G2/M transition of mitotic cell cycle
relationship: positively_regulates GO:0000086 ! G2/M transition of mitotic cell cycle
created_by: tanyaberardini
creation_date: 2009-06-01T10:16:34Z

[Term]
id: GO:0010972
name: negative regulation of G2/M transition of mitotic cell cycle
namespace: biological_process
def: "Any cell cycle regulatory process that decreases the rate or extent of progression of a cell from G2 to M phase of the mitotic cell cycle." [GOC:mtg_cell_cycle]
synonym: "negative regulation of mitotic entry" EXACT [GOC:vw]
is_a: GO:0010389 ! regulation of G2/M transition of mitotic cell cycle
is_a: GO:1901991 ! negative regulation of mitotic cell cycle phase transition
is_a: GO:1902750 ! negative regulation of cell cycle G2/M phase transition
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000086 ! G2/M transition of mitotic cell cycle
relationship: negatively_regulates GO:0000086 ! G2/M transition of mitotic cell cycle
created_by: tanyaberardini
creation_date: 2009-06-01T10:18:29Z

[Term]
id: GO:0010973
name: positive regulation of barrier septum assembly
namespace: biological_process
alt_id: GO:1901912
alt_id: GO:1902470
def: "Any process that increases the frequency, rate or extent of barrier septum formation. Barrier septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis." [GOC:mtg_cell_cycle, PMID:19959363, PMID:21246752, PMID:22786806]
synonym: "activation of barrier septum assembly involved in cell cycle cytokinesis" NARROW [GOC:TermGenie]
synonym: "activation of barrier septum formation involved in cell cycle cytokinesis" NARROW [GOC:TermGenie]
synonym: "activation of barrier septum formation involved in mitotic cell cycle" NARROW [GOC:TermGenie]
synonym: "activation of formation of barrier septum involved in mitotic cell cycle" NARROW [GOC:TermGenie]
synonym: "activation of mitotic barrier septum assembly" NARROW [GOC:TermGenie]
synonym: "activation of septin assembly and septum biosynthesis involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "activation of septin assembly and septum formation involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "positive regulation of barrier septum assembly involved in cell cycle cytokinesis" EXACT []
synonym: "positive regulation of barrier septum formation" EXACT []
synonym: "positive regulation of barrier septum formation involved in cell cycle cytokinesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of barrier septum formation involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "positive regulation of formation of barrier septum involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "positive regulation of mitotic barrier septum assembly" EXACT []
synonym: "positive regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "positive regulation of septin assembly and septum formation involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "up regulation of barrier septum assembly involved in cell cycle cytokinesis" EXACT [GOC:TermGenie]
synonym: "up regulation of barrier septum formation involved in cell cycle cytokinesis" EXACT [GOC:TermGenie]
synonym: "up regulation of barrier septum formation involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "up regulation of formation of barrier septum involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "up regulation of mitotic barrier septum assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "up regulation of septin assembly and septum formation involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "up-regulation of barrier septum assembly involved in cell cycle cytokinesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of barrier septum formation involved in cell cycle cytokinesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of barrier septum formation involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "up-regulation of formation of barrier septum involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitotic barrier septum assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "up-regulation of septin assembly and septum formation involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "upregulation of barrier septum assembly involved in cell cycle cytokinesis" EXACT [GOC:TermGenie]
synonym: "upregulation of barrier septum formation involved in cell cycle cytokinesis" EXACT [GOC:TermGenie]
synonym: "upregulation of barrier septum formation involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "upregulation of formation of barrier septum involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "upregulation of mitotic barrier septum assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of septin assembly and septum biosynthesis involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "upregulation of septin assembly and septum formation involved in mitotic cell cycle" RELATED [GOC:TermGenie]
is_a: GO:0032955 ! regulation of barrier septum assembly
is_a: GO:1901893 ! positive regulation of cell septum assembly
is_a: GO:1903438 ! positive regulation of mitotic cytokinetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000917 ! barrier septum assembly
relationship: positively_regulates GO:0000917 ! barrier septum assembly
created_by: tanyaberardini
creation_date: 2009-06-01T10:27:15Z

[Term]
id: GO:0010974
name: negative regulation of barrier septum assembly
namespace: biological_process
alt_id: GO:1901139
alt_id: GO:1902469
def: "Any process that decreases the frequency, rate or extent of barrier septum formation. Barrier septum formation is he assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis." [GOC:mtg_cell_cycle, PMID:19959363, PMID:21246752, PMID:22786806]
synonym: "down regulation of barrier septum assembly involved in cell cycle cytokinesis" EXACT [GOC:TermGenie]
synonym: "down regulation of barrier septum formation involved in cell cycle cytokinesis" EXACT [GOC:TermGenie]
synonym: "down regulation of barrier septum formation involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "down regulation of formation of barrier septum involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "down regulation of mitotic barrier septum assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "down regulation of septin assembly and septum formation involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "down-regulation of barrier septum assembly involved in cell cycle cytokinesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of barrier septum formation involved in cell cycle cytokinesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of barrier septum formation involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "down-regulation of formation of barrier septum involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitotic barrier septum assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "down-regulation of septin assembly and septum formation involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "downregulation of barrier septum assembly involved in cell cycle cytokinesis" EXACT [GOC:TermGenie]
synonym: "downregulation of barrier septum formation involved in cell cycle cytokinesis" EXACT [GOC:TermGenie]
synonym: "downregulation of barrier septum formation involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "downregulation of formation of barrier septum involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "downregulation of mitotic barrier septum assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of septin assembly and septum biosynthesis involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "downregulation of septin assembly and septum formation involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "inhibition of barrier septum assembly involved in cell cycle cytokinesis" NARROW [GOC:TermGenie]
synonym: "inhibition of barrier septum formation involved in cell cycle cytokinesis" EXACT [GOC:TermGenie]
synonym: "inhibition of barrier septum formation involved in mitotic cell cycle" NARROW [GOC:TermGenie]
synonym: "inhibition of formation of barrier septum involved in mitotic cell cycle" NARROW [GOC:TermGenie]
synonym: "inhibition of mitotic barrier septum assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of septin assembly and septum biosynthesis involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "inhibition of septin assembly and septum formation involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "negative regulation of barrier septum assembly involved in cell cycle cytokinesis" EXACT []
synonym: "negative regulation of barrier septum formation" EXACT []
synonym: "negative regulation of barrier septum formation involved in cell cycle cytokinesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of barrier septum formation involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "negative regulation of formation of barrier septum involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "negative regulation of mitotic barrier septum assembly" EXACT []
synonym: "negative regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "negative regulation of septin assembly and septum formation involved in mitotic cell cycle" RELATED [GOC:TermGenie]
is_a: GO:0032955 ! regulation of barrier septum assembly
is_a: GO:1901892 ! negative regulation of cell septum assembly
is_a: GO:1903437 ! negative regulation of mitotic cytokinetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000917 ! barrier septum assembly
relationship: negatively_regulates GO:0000917 ! barrier septum assembly
created_by: tanyaberardini
creation_date: 2009-06-01T10:32:32Z

[Term]
id: GO:0010975
name: regulation of neuron projection development
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb]
synonym: "regulation of neurite biosynthesis" NARROW [GOC:mah]
synonym: "regulation of neurite development" NARROW [GOC:mah]
synonym: "regulation of neurite formation" NARROW [GOC:mah]
synonym: "regulation of neurite growth" NARROW [GOC:mah]
is_a: GO:0031344 ! regulation of cell projection organization
is_a: GO:0045664 ! regulation of neuron differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031175 ! neuron projection development
relationship: regulates GO:0031175 ! neuron projection development
created_by: tanyaberardini
creation_date: 2009-06-01T10:44:45Z

[Term]
id: GO:0010976
name: positive regulation of neuron projection development
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb]
synonym: "positive regulation of neurite biosynthesis" NARROW [GOC:mah]
synonym: "positive regulation of neurite development" NARROW [GOC:mah]
synonym: "positive regulation of neurite formation" NARROW [GOC:mah]
synonym: "positive regulation of neurite growth" NARROW [GOC:mah]
is_a: GO:0010975 ! regulation of neuron projection development
is_a: GO:0031346 ! positive regulation of cell projection organization
is_a: GO:0045666 ! positive regulation of neuron differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0031175 ! neuron projection development
relationship: positively_regulates GO:0031175 ! neuron projection development
created_by: tanyaberardini
creation_date: 2009-06-01T10:46:44Z

[Term]
id: GO:0010977
name: negative regulation of neuron projection development
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb]
synonym: "growth cone collapse" RELATED [GOC:pr]
synonym: "negative regulation of neurite biosynthesis" NARROW [GOC:mah]
synonym: "negative regulation of neurite development" NARROW [GOC:mah]
synonym: "negative regulation of neurite formation" NARROW [GOC:mah]
synonym: "negative regulation of neurite growth" NARROW [GOC:mah]
is_a: GO:0010975 ! regulation of neuron projection development
is_a: GO:0031345 ! negative regulation of cell projection organization
is_a: GO:0045665 ! negative regulation of neuron differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0031175 ! neuron projection development
relationship: negatively_regulates GO:0031175 ! neuron projection development
created_by: tanyaberardini
creation_date: 2009-06-01T10:47:42Z

[Term]
id: GO:0010978
name: gene silencing involved in chronological cell aging
namespace: biological_process
def: "Any transcriptional or post-transcriptional process, arising in non-dividing cells as they age, carried out at the cellular level that results in long-term gene inactivation." [GOC:dph, GOC:jp, GOC:tb]
is_a: GO:0016458 ! gene silencing
intersection_of: GO:0016458 ! gene silencing
intersection_of: part_of GO:0001300 ! chronological cell aging
relationship: part_of GO:0001300 ! chronological cell aging
created_by: tanyaberardini
creation_date: 2009-06-01T11:39:42Z

[Term]
id: GO:0010979
name: regulation of vitamin D 24-hydroxylase activity
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of vitamin D 24-hydroxylase activity. Vitamin D 24-hydroxylase activity catalyzes the hydroxylation of C-24 of any form of vitamin D." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0051341 ! regulation of oxidoreductase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070576 ! vitamin D 24-hydroxylase activity
relationship: regulates GO:0070576 ! vitamin D 24-hydroxylase activity
created_by: tanyaberardini
creation_date: 2009-06-01T11:44:54Z

[Term]
id: GO:0010980
name: positive regulation of vitamin D 24-hydroxylase activity
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of vitamin D 24-hydroxylase activity. Vitamin D 24-hydroxylase activity catalyzes the hydroxylation of C-24 of any form of vitamin D." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010979 ! regulation of vitamin D 24-hydroxylase activity
is_a: GO:0051353 ! positive regulation of oxidoreductase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070576 ! vitamin D 24-hydroxylase activity
relationship: positively_regulates GO:0070576 ! vitamin D 24-hydroxylase activity
created_by: tanyaberardini
creation_date: 2009-06-01T11:47:19Z

[Term]
id: GO:0010981
name: regulation of cell wall macromolecule metabolic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of cell wall macromolecule metabolism. Cell wall macromolecule metabolic processes are the chemical reactions and pathways involving macromolecules forming, or destined to form, part of the cell wall. A cell wall is a rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:dph, GOC:tb]
is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:0060255 ! regulation of macromolecule metabolic process
is_a: GO:1903338 ! regulation of cell wall organization or biogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044036 ! cell wall macromolecule metabolic process
relationship: regulates GO:0044036 ! cell wall macromolecule metabolic process
created_by: tanyaberardini
creation_date: 2009-06-01T11:55:35Z

[Term]
id: GO:0010982
name: regulation of high-density lipoprotein particle clearance
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of high-density lipoprotein particle clearance. High-density lipoprotein particle clearance is the process in which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010984 ! regulation of lipoprotein particle clearance
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034384 ! high-density lipoprotein particle clearance
relationship: regulates GO:0034384 ! high-density lipoprotein particle clearance
created_by: tanyaberardini
creation_date: 2009-06-01T12:01:30Z

[Term]
id: GO:0010983
name: positive regulation of high-density lipoprotein particle clearance
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of high-density lipoprotein particle clearance. High-density lipoprotein particle clearance is the process in which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010982 ! regulation of high-density lipoprotein particle clearance
is_a: GO:0010986 ! positive regulation of lipoprotein particle clearance
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034384 ! high-density lipoprotein particle clearance
relationship: positively_regulates GO:0034384 ! high-density lipoprotein particle clearance
created_by: tanyaberardini
creation_date: 2009-06-01T12:03:32Z

[Term]
id: GO:0010984
name: regulation of lipoprotein particle clearance
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of lipoprotein particle clearance. Lipoprotein particle clearance is the process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034381 ! plasma lipoprotein particle clearance
relationship: regulates GO:0034381 ! plasma lipoprotein particle clearance
created_by: tanyaberardini
creation_date: 2009-06-01T12:05:12Z

[Term]
id: GO:0010985
name: negative regulation of lipoprotein particle clearance
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of lipoprotein particle clearance. Lipoprotein particle clearance is the process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010984 ! regulation of lipoprotein particle clearance
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034381 ! plasma lipoprotein particle clearance
relationship: negatively_regulates GO:0034381 ! plasma lipoprotein particle clearance
created_by: tanyaberardini
creation_date: 2009-06-01T12:06:59Z

[Term]
id: GO:0010986
name: positive regulation of lipoprotein particle clearance
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of lipoprotein particle clearance. Lipoprotein particle clearance is the process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010984 ! regulation of lipoprotein particle clearance
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034381 ! plasma lipoprotein particle clearance
relationship: positively_regulates GO:0034381 ! plasma lipoprotein particle clearance
created_by: tanyaberardini
creation_date: 2009-06-01T12:08:19Z

[Term]
id: GO:0010987
name: negative regulation of high-density lipoprotein particle clearance
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of high-density lipoprotein particle clearance. High-density lipoprotein particle clearance is the process in which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010982 ! regulation of high-density lipoprotein particle clearance
is_a: GO:0010985 ! negative regulation of lipoprotein particle clearance
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034384 ! high-density lipoprotein particle clearance
relationship: negatively_regulates GO:0034384 ! high-density lipoprotein particle clearance
created_by: tanyaberardini
creation_date: 2009-06-01T12:09:36Z

[Term]
id: GO:0010988
name: regulation of low-density lipoprotein particle clearance
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of low-density lipoprotein particle clearance. Low-density lipoprotein particle clearance is the process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010984 ! regulation of lipoprotein particle clearance
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034383 ! low-density lipoprotein particle clearance
relationship: regulates GO:0034383 ! low-density lipoprotein particle clearance
created_by: tanyaberardini
creation_date: 2009-06-01T12:13:07Z

[Term]
id: GO:0010989
name: negative regulation of low-density lipoprotein particle clearance
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of low-density lipoprotein particle clearance. Low-density lipoprotein particle clearance is the process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010985 ! negative regulation of lipoprotein particle clearance
is_a: GO:0010988 ! regulation of low-density lipoprotein particle clearance
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034383 ! low-density lipoprotein particle clearance
relationship: negatively_regulates GO:0034383 ! low-density lipoprotein particle clearance
created_by: tanyaberardini
creation_date: 2009-06-01T12:15:07Z

[Term]
id: GO:0010990
name: regulation of SMAD protein complex assembly
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of SMAD protein complex assembly. SMAD protein complex assembly is the aggregation, arrangement and bonding together of a set of components to form a protein complex that contains SMAD proteins." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0043254 ! regulation of protein complex assembly
is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007183 ! SMAD protein complex assembly
relationship: regulates GO:0007183 ! SMAD protein complex assembly
created_by: tanyaberardini
creation_date: 2009-06-03T11:28:05Z

[Term]
id: GO:0010991
name: negative regulation of SMAD protein complex assembly
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of SMAD protein complex assembly. SMAD protein complex assembly is the aggregation, arrangement and bonding together of a set of components to form a protein complex that contains SMAD proteins." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010990 ! regulation of SMAD protein complex assembly
is_a: GO:0031333 ! negative regulation of protein complex assembly
is_a: GO:0090101 ! negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007183 ! SMAD protein complex assembly
relationship: negatively_regulates GO:0007183 ! SMAD protein complex assembly
created_by: tanyaberardini
creation_date: 2009-06-03T11:30:44Z

[Term]
id: GO:0010992
name: ubiquitin homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of ubiquitin monomers and free ubiquitin chains at the level of the cell." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0019725 ! cellular homeostasis
created_by: tanyaberardini
creation_date: 2009-06-03T11:36:55Z

[Term]
id: GO:0010993
name: regulation of ubiquitin homeostasis
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of ubiquitin homeostasis. Ubiquitin homeostasis is any process involved in the maintenance of an internal steady state of ubiquitin monomers and free ubiquitin chains at the level of the cell." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0032844 ! regulation of homeostatic process
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010992 ! ubiquitin homeostasis
relationship: regulates GO:0010992 ! ubiquitin homeostasis
created_by: tanyaberardini
creation_date: 2009-06-03T11:38:54Z

[Term]
id: GO:0010994
name: free ubiquitin chain polymerization
namespace: biological_process
def: "The process of creating free ubiquitin chains, compounds composed of a large number of ubiquitin monomers. These chains are not conjugated to a protein." [GOC:BHF, GOC:dph, GOC:tb]
xref: Reactome:REACT_25317 "Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex dsRNA :TLR3 :TIKAM1, Gallus gallus"
xref: Reactome:REACT_25386 "Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex p-IRAK2:pUb_oligo TRAF6, Gallus gallus"
xref: Reactome:REACT_27265 "Activated TRAF6 synthesizes free K63 linked pUb chains., Gallus gallus"
is_a: GO:0051258 ! protein polymerization
relationship: part_of GO:0010993 ! regulation of ubiquitin homeostasis
created_by: tanyaberardini
creation_date: 2009-06-03T11:41:03Z

[Term]
id: GO:0010995
name: free ubiquitin chain depolymerization
namespace: biological_process
def: "The process in which free ubiquitin chains, compounds composed of a large number of ubiquitin monomers, are broken down." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0051261 ! protein depolymerization
relationship: part_of GO:0010993 ! regulation of ubiquitin homeostasis
created_by: tanyaberardini
creation_date: 2009-06-03T11:45:42Z

[Term]
id: GO:0010996
name: response to auditory stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auditory stimulus." [GOC:BHF, GOC:dph, GOC:sl, GOC:tb]
synonym: "response to sound" EXACT [GOC:dph, GOC:sl, GOC:tb]
synonym: "response to sound stimulus" EXACT [GOC:dph, GOC:tb]
is_a: GO:0009612 ! response to mechanical stimulus
created_by: tanyaberardini
creation_date: 2009-06-10T11:09:38Z

[Term]
id: GO:0010997
name: anaphase-promoting complex binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an anaphase-promoting complex. A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "APC binding" EXACT [GOC:dph, GOC:tb]
is_a: GO:0032403 ! protein complex binding
created_by: tanyaberardini
creation_date: 2009-06-10T11:18:22Z

[Term]
id: GO:0010998
name: regulation of translational initiation by eIF2 alpha phosphorylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of translation initiation in response to stress by the phosphorylation of eIF2 alpha." [GOC:BHF, GOC:dph, GOC:hjd, GOC:tb]
comment: Consider also annotating to 'eukaryotic translation initiation factor 2alpha kinase activity ; GO:0004694'.
synonym: "eIF2 alpha phosphorylation in response to stress" EXACT [GOC:bf]
synonym: "regulation of translational initiation by eIF2 alpha phosphorylation in response to stress" EXACT [GOC:bf]
is_a: GO:0006468 ! protein phosphorylation
is_a: GO:0043558 ! regulation of translational initiation in response to stress
is_a: GO:0044710 ! single-organism metabolic process
is_a: GO:0044763 ! single-organism cellular process
created_by: tanyaberardini
creation_date: 2009-06-10T11:27:47Z

[Term]
id: GO:0010999
name: regulation of eIF2 alpha phosphorylation by heme
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a result of heme levels." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0001932 ! regulation of protein phosphorylation
is_a: GO:0006446 ! regulation of translational initiation
is_a: GO:0080135 ! regulation of cellular response to stress
relationship: regulates GO:0010998 ! regulation of translational initiation by eIF2 alpha phosphorylation
created_by: tanyaberardini
creation_date: 2009-06-10T11:42:10Z

[Term]
id: GO:0011000
name: replication fork arrest at mating type locus
namespace: biological_process
def: "A process that impedes the progress of the DNA replication fork at natural replication fork pausing sites within the mating type locus." [GOC:dph, GOC:tb]
is_a: GO:0043111 ! replication fork arrest
created_by: tanyaberardini
creation_date: 2009-06-24T12:02:48Z

[Term]
id: GO:0012501
name: programmed cell death
namespace: biological_process
alt_id: GO:0016244
def: "A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis]
comment: Note that this term should be used to annotate gene products in the organism undergoing the programmed cell death. To annotate genes in another organism whose products modulate programmed cell death in a host organism, consider the term 'modulation by symbiont of host programmed cell death ; GO:0052040'. Also, note that 'programmed cell death ; GO:0012501' should be used to refer to instances of caspase-independent cell death mechanisms, in the absence of further indications on the process taking place. At present, caspase-independent cell death is not yet represented in GO due to the lack of consensus and in-depth research on the topic. 'programmed cell death ; GO:0012501' may also be used to annotate gene products in taxa where apoptosis as defined in GO:0006915 does not occur, such as plants. You may also consider these specific children: GO:0097468 'programmed cell death in response to reactive oxygen species' (with descendants GO:0010421 'hydrogen peroxide-mediated programmed cell death' and GO:0010343 'singlet oxygen-mediated programmed cell death'), and GO:0009626 'plant-type hypersensitive response' and its children, which are descendants of GO:0034050 'host programmed cell death induced by symbiont'.
synonym: "caspase-independent apoptosis" RELATED []
synonym: "caspase-independent cell death" NARROW []
synonym: "non-apoptotic programmed cell death" NARROW []
synonym: "nonapoptotic programmed cell death" NARROW []
synonym: "PCD" RELATED []
synonym: "RCD" RELATED []
synonym: "regulated cell death" BROAD []
xref: Wikipedia:Programmed_cell_death
is_a: GO:0008219 ! cell death

[Term]
id: GO:0012502
name: induction of programmed cell death
namespace: biological_process
alt_id: GO:0012503
def: "A process which directly activates any of the steps required for programmed cell death." [GOC:lr]
synonym: "induction of non-apoptotic programmed cell death" NARROW []
synonym: "induction of nonapoptotic programmed cell death" NARROW []
is_a: GO:0043068 ! positive regulation of programmed cell death

[Term]
id: GO:0012505
name: endomembrane system
namespace: cellular_component
def: "A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh]
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_yeast
xref: Wikipedia:Endomembrane_system
is_a: GO:0044464 ! cell part
relationship: has_part GO:0005773 ! vacuole
relationship: has_part GO:0005886 ! plasma membrane

[Term]
id: GO:0012506
name: vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding any membrane-bounded vesicle in the cell." [GOC:mah, GOC:vesicle]
xref: NIF_Subcellular:sao1153182838
is_a: GO:0031090 ! organelle membrane
relationship: part_of GO:0031982 ! vesicle

[Term]
id: GO:0012507
name: ER to Golgi transport vesicle membrane
namespace: cellular_component
alt_id: GO:0030664
def: "The lipid bilayer surrounding a vesicle transporting substances from the endoplasmic reticulum to the Golgi." [GOC:ai, GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "COPII coated vesicle membrane" EXACT []
synonym: "endoplasmic reticulum to Golgi transport vesicle membrane" EXACT []
synonym: "endoplasmic reticulum-Golgi transport vesicle membrane" EXACT []
synonym: "ER to Golgi constitutive secretory pathway transport vesicle membrane" EXACT []
synonym: "ER-Golgi transport vesicle membrane" EXACT []
is_a: GO:0030658 ! transport vesicle membrane
is_a: GO:0030662 ! coated vesicle membrane
relationship: part_of GO:0030134 ! ER to Golgi transport vesicle

[Term]
id: GO:0012508
name: Golgi to ER transport vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a vesicle transporting substances from the Golgi to the ER." [GOC:ai]
synonym: "Golgi to endoplasmic reticulum transport vesicle membrane" EXACT []
synonym: "Golgi to ER constitutive secretory pathway transport vesicle membrane" EXACT []
synonym: "Golgi-endoplasmic reticulum transport vesicle membrane" EXACT []
synonym: "Golgi-ER transport vesicle membrane" EXACT []
is_a: GO:0030658 ! transport vesicle membrane
is_a: GO:0030663 ! COPI-coated vesicle membrane
relationship: part_of GO:0030142 ! Golgi to ER transport vesicle

[Term]
id: GO:0012509
name: inter-Golgi transport vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a vesicle transporting substances within the Golgi." [GOC:ai]
synonym: "inter-Golgi transport constitutive secretory pathway transport vesicle membrane" EXACT []
is_a: GO:0030658 ! transport vesicle membrane
is_a: GO:0030663 ! COPI-coated vesicle membrane
relationship: part_of GO:0030143 ! inter-Golgi transport vesicle

[Term]
id: GO:0012510
name: trans-Golgi network transport vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a vesicle transporting substances between the trans-Golgi network and other parts of the cell." [GOC:ai]
synonym: "TGN transport vesicle membrane" EXACT []
synonym: "trans-Golgi network constitutive secretory pathway transport vesicle membrane" EXACT []
is_a: GO:0030658 ! transport vesicle membrane
is_a: GO:0030660 ! Golgi-associated vesicle membrane
is_a: GO:0030665 ! clathrin-coated vesicle membrane
relationship: part_of GO:0030140 ! trans-Golgi network transport vesicle

[Term]
id: GO:0012511
name: monolayer-surrounded lipid storage body
namespace: cellular_component
alt_id: GO:0009520
def: "A subcellular organelle of plant cells surrounded by 'half-unit' or a monolayer membrane instead of the more usual bilayer. The storage body has a droplet of triglyceride surrounded by a monolayer of phospholipids, interacting with the triglycerides and the hydrophilic head groups facing the cytosol, and containing major protein components called oleosins." [GOC:mtg_sensu, ISBN:0943088372]
synonym: "oil body" EXACT []
synonym: "oilbody" EXACT []
synonym: "oleosome" EXACT []
synonym: "spherosome" EXACT []
xref: Wikipedia:Oil_body
is_a: GO:0005811 ! lipid particle

[Term]
id: GO:0014001
name: sclerenchyma cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a sclerenchyma cell. A sclerenchyma cell is a plant cell with thick lignified walls, normally dead at maturity and specialized for structural strength. Includes fiber cells, that are greatly elongated; and sclereids, that are more isodiametric. Intermediate types exist. Cells may or may not be devoid of protoplasm at maturity. Cell form and size are variable." [CL:0000276, GOC:ef, GOC:jid, PO:0000077]
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0014002
name: astrocyte development
namespace: biological_process
def: "The process aimed at the progression of an astrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function." [GOC:dgh, GOC:ef]
synonym: "astrocyte cell development" EXACT []
is_a: GO:0021782 ! glial cell development
relationship: part_of GO:0048708 ! astrocyte differentiation

[Term]
id: GO:0014003
name: oligodendrocyte development
namespace: biological_process
def: "The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system." [GOC:dgh, GOC:ef]
synonym: "oligodendrocyte cell development" EXACT []
is_a: GO:0021782 ! glial cell development
relationship: part_of GO:0048709 ! oligodendrocyte differentiation

[Term]
id: GO:0014004
name: microglia differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a microglial cell. Microglia are glial cells that act as the immune cells of the central nervous system. They form part of the supporting structure of this system." [GOC:ef]
synonym: "microglial cell differentiation" EXACT []
is_a: GO:0010001 ! glial cell differentiation
is_a: GO:0030225 ! macrophage differentiation
relationship: part_of GO:0007417 ! central nervous system development

[Term]
id: GO:0014005
name: microglia development
namespace: biological_process
def: "The process aimed at the progression of a microglial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dgh, GOC:ef]
synonym: "microglial cell development" EXACT []
is_a: GO:0021782 ! glial cell development
is_a: GO:0061515 ! myeloid cell development
relationship: part_of GO:0014004 ! microglia differentiation

[Term]
id: GO:0014006
name: regulation of microglia differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of microglia differentiation, the process in which a relatively unspecialized cell acquires specialized features of a microglial cell." [GOC:ef]
synonym: "regulation of microglial cell differentiation" EXACT []
is_a: GO:0045649 ! regulation of macrophage differentiation
is_a: GO:0045685 ! regulation of glial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0014004 ! microglia differentiation
relationship: regulates GO:0014004 ! microglia differentiation

[Term]
id: GO:0014007
name: negative regulation of microglia differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of microglia differentiation, the process in which a relatively unspecialized cell acquires specialized features of a microglial cell." [GOC:ef]
synonym: "down regulation of microglia differentiation" EXACT []
synonym: "down-regulation of microglia differentiation" EXACT []
synonym: "downregulation of microglia differentiation" EXACT []
synonym: "inhibition of microglia differentiation" NARROW []
synonym: "negative regulation of microglial cell differentiation" EXACT []
is_a: GO:0014006 ! regulation of microglia differentiation
is_a: GO:0045650 ! negative regulation of macrophage differentiation
is_a: GO:0045686 ! negative regulation of glial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0014004 ! microglia differentiation
relationship: negatively_regulates GO:0014004 ! microglia differentiation

[Term]
id: GO:0014008
name: positive regulation of microglia differentiation
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of microglia differentiation, the process in which a relatively unspecialized cell acquires specialized features of a microglial cell." [GOC:ef]
synonym: "activation of microglia differentiation" NARROW []
synonym: "positive regulation of microglial cell differentiation" EXACT []
synonym: "stimulation of microglia differentiation" NARROW []
synonym: "up regulation of microglia differentiation" EXACT []
synonym: "up-regulation of microglia differentiation" EXACT []
synonym: "upregulation of microglia differentiation" EXACT []
is_a: GO:0014006 ! regulation of microglia differentiation
is_a: GO:0045651 ! positive regulation of macrophage differentiation
is_a: GO:0045687 ! positive regulation of glial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0014004 ! microglia differentiation
relationship: positively_regulates GO:0014004 ! microglia differentiation

[Term]
id: GO:0014009
name: glial cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of glial cells by cell division, resulting in the expansion of their population. Glial cells exist throughout the nervous system, and include Schwann cells, astrocytes, and oligodendrocytes among others." [GOC:ef, ISBN:0878932585]
synonym: "glia proliferation" EXACT []
is_a: GO:0008283 ! cell proliferation
relationship: part_of GO:0042063 ! gliogenesis

[Term]
id: GO:0014010
name: Schwann cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system." [GOC:ef, ISBN:0878932585]
is_a: GO:0014009 ! glial cell proliferation

[Term]
id: GO:0014011
name: Schwann cell proliferation involved in axon regeneration
namespace: biological_process
def: "The multiplication or reproduction of Schwann cells by cell division, resulting in the expansion of their population in response to an axonal lesion. The newly generated Schwann cells support subsequent axon regeneration in the peripheral nervous system." [GOC:ef, ISBN:0878932585]
is_a: GO:0014010 ! Schwann cell proliferation
intersection_of: GO:0014010 ! Schwann cell proliferation
intersection_of: part_of GO:0031103 ! axon regeneration
relationship: part_of GO:0014012 ! peripheral nervous system axon regeneration
relationship: part_of GO:0031103 ! axon regeneration

[Term]
id: GO:0014012
name: peripheral nervous system axon regeneration
namespace: biological_process
def: "The regrowth of axons outside the central nervous system (outside the brain and spinal cord) following an axonal injury." [GOC:ef]
synonym: "axon regeneration in peripheral nervous system" EXACT [GOC:curators]
is_a: GO:0031103 ! axon regeneration

[Term]
id: GO:0014013
name: regulation of gliogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gliogenesis, the formation of mature glia." [GOC:ef]
is_a: GO:0050767 ! regulation of neurogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042063 ! gliogenesis
relationship: regulates GO:0042063 ! gliogenesis

[Term]
id: GO:0014014
name: negative regulation of gliogenesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of gliogenesis, the formation of mature glia." [GOC:ef]
synonym: "down regulation of gliogenesis" EXACT []
synonym: "down-regulation of gliogenesis" EXACT []
synonym: "downregulation of gliogenesis" EXACT []
synonym: "inhibition of gliogenesis" NARROW []
is_a: GO:0014013 ! regulation of gliogenesis
is_a: GO:0050768 ! negative regulation of neurogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042063 ! gliogenesis
relationship: negatively_regulates GO:0042063 ! gliogenesis

[Term]
id: GO:0014015
name: positive regulation of gliogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of gliogenesis, the formation of mature glia." [GOC:ef]
synonym: "activation of gliogenesis" NARROW []
synonym: "stimulation of gliogenesis" NARROW []
synonym: "up regulation of gliogenesis" EXACT []
synonym: "up-regulation of gliogenesis" EXACT []
synonym: "upregulation of gliogenesis" EXACT []
is_a: GO:0014013 ! regulation of gliogenesis
is_a: GO:0050769 ! positive regulation of neurogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042063 ! gliogenesis
relationship: positively_regulates GO:0042063 ! gliogenesis

[Term]
id: GO:0014016
name: neuroblast differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neuroblast. There are at least four stages through which the pluripotent cells of epiblast or blastula become neuroblasts." [GOC:ef, ISBN:0878932585]
is_a: GO:0048863 ! stem cell differentiation
relationship: part_of GO:0048699 ! generation of neurons

[Term]
id: GO:0014017
name: neuroblast fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will differentiate into a neuroblast." [GOC:ef, ISBN:0878932585]
is_a: GO:0048865 ! stem cell fate commitment
relationship: part_of GO:0014016 ! neuroblast differentiation

[Term]
id: GO:0014018
name: neuroblast fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a neuroblast in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:ef, ISBN:0878932585]
is_a: GO:0048866 ! stem cell fate specification
relationship: part_of GO:0014017 ! neuroblast fate commitment

[Term]
id: GO:0014019
name: neuroblast development
namespace: biological_process
def: "The process aimed at the progression of a neuroblast over time, from initial commitment of the cell to a specific state, to the mature neuroblast. It does not include processes where the neuroblast turns into a glial cell or a neuron." [GOC:ef, ISBN:0878932585]
is_a: GO:0048864 ! stem cell development
relationship: part_of GO:0014016 ! neuroblast differentiation

[Term]
id: GO:0014020
name: primary neural tube formation
namespace: biological_process
def: "The formation of the neural tube from an epithelial cell sheet (the neuroepithelium or neural plate). In primary neurulation, the cells surrounding the neural plate direct the neural plate cells to proliferate, invaginate, and pinch off from the surface to form a hollow epithelial tube. Primary neurulation is the typical mechanism of formation of the anterior neural tube." [GOC:ef, ISBN:0878932585]
synonym: "primary neural tube morphogenesis" EXACT [GOC:dph]
synonym: "primary neurulation" EXACT []
is_a: GO:0001838 ! embryonic epithelial tube formation
relationship: part_of GO:0001841 ! neural tube formation

[Term]
id: GO:0014021
name: secondary neural tube formation
namespace: biological_process
alt_id: GO:0014026
def: "The formation of the neural tube by coalescence of mesenchymal cells followed by their conversion to epithelial cells to form a solid cord that subsequently hollows out (cavitates) to create a hollow tube. Secondary neurulation is the typical mechanism of formation of the neural tube posterior to the posterior neuropore in mammals." [GOC:ef, ISBN:0878932585]
synonym: "medullary cord biosynthesis" EXACT []
synonym: "medullary cord formation" EXACT []
synonym: "neural rod formation" RELATED []
synonym: "secondary neurulation" EXACT []
is_a: GO:0001838 ! embryonic epithelial tube formation
relationship: part_of GO:0001841 ! neural tube formation

[Term]
id: GO:0014022
name: neural plate elongation
namespace: biological_process
def: "The process in which the neural plate is shaped by the intrinsic movement of the epidermal and neural plate regions." [GOC:ef, ISBN:0878932585]
is_a: GO:0002011 ! morphogenesis of an epithelial sheet
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0001839 ! neural plate morphogenesis

[Term]
id: GO:0014023
name: neural rod formation
namespace: biological_process
def: "The formation of a solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts." [GOC:dh, GOC:ef]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0014020 ! primary neural tube formation

[Term]
id: GO:0014024
name: neural rod cavitation
namespace: biological_process
def: "The process of rod cavitation, which is the formation of a lumen in the neural rod during primary neurulation, producing the neural tube." [GOC:ef, PMID:15327780]
is_a: GO:0060605 ! tube lumen cavitation
relationship: part_of GO:0014020 ! primary neural tube formation

[Term]
id: GO:0014025
name: neural keel formation
namespace: biological_process
def: "The formation of a thickened region of the neurectoderm that is roughly triangular in cross section. The neural keel develops from the neural plate and develops into the neural rod. Neural keel formation occurs during primary neurulation in teleosts." [GOC:dh, GOC:ef]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0014023 ! neural rod formation

[Term]
id: GO:0014027
name: secondary neural tube rod cavitation
namespace: biological_process
def: "The process of medullary cavitation, which is the formation of a lumen in the medullary cord during secondary neurulation, producing the neural tube." [GOC:ef, PMID:15327780]
synonym: "medullary rod cavitation" EXACT []
is_a: GO:0060605 ! tube lumen cavitation
relationship: part_of GO:0014021 ! secondary neural tube formation

[Term]
id: GO:0014028
name: notochord formation
namespace: biological_process
def: "The formation of the notochord from the chordamesoderm. The notochord is composed of large cells packed within a firm connective tissue sheath and is found in all chordates at the ventral surface of the neural tube. In vertebrates, the notochord contributes to the vertebral column." [GOC:dh, GOC:ef]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0007399 ! nervous system development
relationship: part_of GO:0048570 ! notochord morphogenesis

[Term]
id: GO:0014029
name: neural crest formation
namespace: biological_process
def: "The formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes." [GOC:dh, GOC:ef]
is_a: GO:0001837 ! epithelial to mesenchymal transition
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0043009 ! chordate embryonic development

[Term]
id: GO:0014030
name: mesenchymal cell fate commitment
namespace: biological_process
def: "The process in which a cell becomes committed to become a mesenchymal cell." [GOC:dh, GOC:ef]
is_a: GO:0048865 ! stem cell fate commitment
relationship: part_of GO:0048762 ! mesenchymal cell differentiation

[Term]
id: GO:0014031
name: mesenchymal cell development
namespace: biological_process
def: "The process aimed at the progression of a mesenchymal cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dh, GOC:ef]
is_a: GO:0048864 ! stem cell development
relationship: part_of GO:0048762 ! mesenchymal cell differentiation

[Term]
id: GO:0014032
name: neural crest cell development
namespace: biological_process
def: "The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dh, GOC:ef]
is_a: GO:0014031 ! mesenchymal cell development
relationship: part_of GO:0014033 ! neural crest cell differentiation

[Term]
id: GO:0014033
name: neural crest cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell." [GOC:dh, GOC:ef]
is_a: GO:0048762 ! mesenchymal cell differentiation

[Term]
id: GO:0014034
name: neural crest cell fate commitment
namespace: biological_process
def: "The process in which a cell becomes committed to become a neural crest cell." [GOC:dh, GOC:ef]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0014029 ! neural crest formation
relationship: part_of GO:0014033 ! neural crest cell differentiation

[Term]
id: GO:0014035
name: neural crest cell fate determination
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a neural crest cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:dh, GOC:ef]
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0014034 ! neural crest cell fate commitment

[Term]
id: GO:0014036
name: neural crest cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a neural crest cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:dh, GOC:ef]
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0014034 ! neural crest cell fate commitment

[Term]
id: GO:0014037
name: Schwann cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a Schwann cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function." [GOC:ef]
is_a: GO:0010001 ! glial cell differentiation
relationship: part_of GO:0007422 ! peripheral nervous system development

[Term]
id: GO:0014038
name: regulation of Schwann cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Schwann cell differentiation." [GOC:ef]
is_a: GO:0045685 ! regulation of glial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0014037 ! Schwann cell differentiation
relationship: regulates GO:0014037 ! Schwann cell differentiation

[Term]
id: GO:0014039
name: negative regulation of Schwann cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Schwann cell differentiation." [GOC:ef]
synonym: "down regulation of Schwann cell differentiation" EXACT []
synonym: "down-regulation of Schwann cell differentiation" EXACT []
synonym: "downregulation of Schwann cell differentiation" EXACT []
synonym: "inhibition of Schwann cell differentiation" NARROW []
is_a: GO:0014038 ! regulation of Schwann cell differentiation
is_a: GO:0045686 ! negative regulation of glial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0014037 ! Schwann cell differentiation
relationship: negatively_regulates GO:0014037 ! Schwann cell differentiation

[Term]
id: GO:0014040
name: positive regulation of Schwann cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of Schwann cell differentiation." [GOC:ef]
synonym: "activation of Schwann cell differentiation" NARROW []
synonym: "stimulation of Schwann cell differentiation" NARROW []
synonym: "up regulation of Schwann cell differentiation" EXACT []
synonym: "up-regulation of Schwann cell differentiation" EXACT []
synonym: "upregulation of Schwann cell differentiation" EXACT []
is_a: GO:0014038 ! regulation of Schwann cell differentiation
is_a: GO:0045687 ! positive regulation of glial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0014037 ! Schwann cell differentiation
relationship: positively_regulates GO:0014037 ! Schwann cell differentiation

[Term]
id: GO:0014041
name: regulation of neuron maturation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neuron maturation, the process leading to the attainment of the full functional capacity of a neuron. This process is independent of morphogenetic change." [GOC:ef]
is_a: GO:0045664 ! regulation of neuron differentiation
is_a: GO:1903429 ! regulation of cell maturation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042551 ! neuron maturation
relationship: regulates GO:0042551 ! neuron maturation

[Term]
id: GO:0014042
name: positive regulation of neuron maturation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neuron maturation." [GOC:ef]
synonym: "activation of neuron maturation" NARROW []
synonym: "stimulation of neuron maturation" NARROW []
synonym: "up regulation of neuron maturation" EXACT []
synonym: "up-regulation of neuron maturation" EXACT []
synonym: "upregulation of neuron maturation" EXACT []
is_a: GO:0014041 ! regulation of neuron maturation
is_a: GO:0045666 ! positive regulation of neuron differentiation
is_a: GO:1903431 ! positive regulation of cell maturation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042551 ! neuron maturation
relationship: positively_regulates GO:0042551 ! neuron maturation

[Term]
id: GO:0014043
name: negative regulation of neuron maturation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neuron maturation." [GOC:ef]
synonym: "down regulation of neuron maturation" EXACT []
synonym: "down-regulation of neuron maturation" EXACT []
synonym: "downregulation of neuron maturation" EXACT []
synonym: "inhibition of neuron maturation" NARROW []
is_a: GO:0014041 ! regulation of neuron maturation
is_a: GO:0045665 ! negative regulation of neuron differentiation
is_a: GO:1903430 ! negative regulation of cell maturation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042551 ! neuron maturation
relationship: negatively_regulates GO:0042551 ! neuron maturation

[Term]
id: GO:0014044
name: Schwann cell development
namespace: biological_process
def: "The process aimed at the progression of a Schwann cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function." [GOC:dgh, GOC:ef]
is_a: GO:0021782 ! glial cell development
relationship: part_of GO:0014037 ! Schwann cell differentiation

[Term]
id: GO:0014045
name: establishment of endothelial blood-brain barrier
namespace: biological_process
def: "Establishment of the endothelial barrier between the blood and the brain. The endothelial cells in the brain capillaries are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier." [GOC:dgh, GOC:dph, GOC:sart]
synonym: "establishment of endothelial BBB" EXACT [PMID:20080302]
synonym: "establishment of endothelial blood/brain barrier" EXACT []
is_a: GO:0060856 ! establishment of blood-brain barrier
is_a: GO:0061028 ! establishment of endothelial barrier
relationship: part_of GO:0007417 ! central nervous system development

[Term]
id: GO:0014046
name: dopamine secretion
namespace: biological_process
def: "The regulated release of dopamine by a cell. Dopamine is a catecholamine and a precursor of adrenaline and noradrenaline. It acts as a neurotransmitter in the central nervous system but it is also produced peripherally and acts as a hormone." [GOC:ef]
is_a: GO:0015872 ! dopamine transport
is_a: GO:0050432 ! catecholamine secretion

[Term]
id: GO:0014047
name: glutamate secretion
namespace: biological_process
def: "The controlled release of glutamate by a cell. The glutamate is the most abundant excitatory neurotransmitter in the nervous system." [GOC:ef]
xref: Reactome:REACT_109562 "Glutamate Neurotransmitter Release Cycle, Gallus gallus"
xref: Reactome:REACT_110427 "Glutamate Neurotransmitter Release Cycle, Escherichia coli"
xref: Reactome:REACT_110783 "Glutamate Neurotransmitter Release Cycle, Drosophila melanogaster"
xref: Reactome:REACT_112750 "Glutamate Neurotransmitter Release Cycle, Staphylococcus aureus N315"
xref: Reactome:REACT_12591 "Glutamate Neurotransmitter Release Cycle, Homo sapiens"
xref: Reactome:REACT_28102 "Glutamate Neurotransmitter Release Cycle, Bos taurus"
xref: Reactome:REACT_28436 "Glutamate Neurotransmitter Release Cycle, Canis familiaris"
xref: Reactome:REACT_29157 "Glutamate Neurotransmitter Release Cycle, Rattus norvegicus"
xref: Reactome:REACT_30788 "Glutamate Neurotransmitter Release Cycle, Mus musculus"
xref: Reactome:REACT_32657 "Glutamate Neurotransmitter Release Cycle, Arabidopsis thaliana"
xref: Reactome:REACT_78627 "Glutamate Neurotransmitter Release Cycle, Caenorhabditis elegans"
xref: Reactome:REACT_79842 "Glutamate Neurotransmitter Release Cycle, Oryza sativa"
xref: Reactome:REACT_89854 "Glutamate Neurotransmitter Release Cycle, Danio rerio"
xref: Reactome:REACT_94050 "Glutamate Neurotransmitter Release Cycle, Sus scrofa"
xref: Reactome:REACT_94627 "Glutamate Neurotransmitter Release Cycle, Taeniopygia guttata"
xref: Reactome:REACT_95715 "Glutamate Neurotransmitter Release Cycle, Xenopus tropicalis"
is_a: GO:0006835 ! dicarboxylic acid transport
is_a: GO:0006865 ! amino acid transport
is_a: GO:0032940 ! secretion by cell
is_a: GO:0046717 ! acid secretion

[Term]
id: GO:0014048
name: regulation of glutamate secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the controlled release of glutamate." [GOC:ef]
is_a: GO:0051955 ! regulation of amino acid transport
is_a: GO:1903530 ! regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0014047 ! glutamate secretion
relationship: regulates GO:0014047 ! glutamate secretion

[Term]
id: GO:0014049
name: positive regulation of glutamate secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the controlled release of glutamate." [GOC:ef]
synonym: "activation of glutamate secretion" NARROW []
synonym: "stimulation of glutamate secretion" NARROW []
synonym: "up regulation of glutamate secretion" EXACT []
synonym: "up-regulation of glutamate secretion" EXACT []
synonym: "upregulation of glutamate secretion" EXACT []
is_a: GO:0014048 ! regulation of glutamate secretion
is_a: GO:0051957 ! positive regulation of amino acid transport
is_a: GO:1903532 ! positive regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0014047 ! glutamate secretion
relationship: positively_regulates GO:0014047 ! glutamate secretion

[Term]
id: GO:0014050
name: negative regulation of glutamate secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of glutamate." [GOC:ef]
synonym: "down regulation of glutamate secretion" EXACT []
synonym: "down-regulation of glutamate secretion" EXACT []
synonym: "downregulation of glutamate secretion" EXACT []
synonym: "inhibition of glutamate secretion" NARROW []
is_a: GO:0014048 ! regulation of glutamate secretion
is_a: GO:0051956 ! negative regulation of amino acid transport
is_a: GO:1903531 ! negative regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0014047 ! glutamate secretion
relationship: negatively_regulates GO:0014047 ! glutamate secretion

[Term]
id: GO:0014051
name: gamma-aminobutyric acid secretion
namespace: biological_process
def: "The regulated release of gamma-aminobutyric acid by a cell or a tissue. The gamma-aminobutyric acid is the principal inhibitory neurotransmitter in the brain but is also found in several extraneural tissues." [GOC:ef]
synonym: "GABA secretion" EXACT []
is_a: GO:0015812 ! gamma-aminobutyric acid transport
is_a: GO:0046717 ! acid secretion

[Term]
id: GO:0014052
name: regulation of gamma-aminobutyric acid secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of gamma-aminobutyric acid." [GOC:ef]
synonym: "regulation of GABA secretion" EXACT []
is_a: GO:0051046 ! regulation of secretion
is_a: GO:0051955 ! regulation of amino acid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0014051 ! gamma-aminobutyric acid secretion
relationship: regulates GO:0014051 ! gamma-aminobutyric acid secretion

[Term]
id: GO:0014053
name: negative regulation of gamma-aminobutyric acid secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of gamma-aminobutyric acid." [GOC:ef]
synonym: "down regulation of gamma-aminobutyric acid secretion" EXACT []
synonym: "down-regulation of gamma-aminobutyric acid secretion" EXACT []
synonym: "downregulation of gamma-aminobutyric acid secretion" EXACT []
synonym: "inhibition of gamma-aminobutyric acid secretion" NARROW []
synonym: "negative regulation of GABA secretion" EXACT []
is_a: GO:0014052 ! regulation of gamma-aminobutyric acid secretion
is_a: GO:0051048 ! negative regulation of secretion
is_a: GO:0051956 ! negative regulation of amino acid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0014051 ! gamma-aminobutyric acid secretion
relationship: negatively_regulates GO:0014051 ! gamma-aminobutyric acid secretion

[Term]
id: GO:0014054
name: positive regulation of gamma-aminobutyric acid secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of gamma-aminobutyric acid." [GOC:ef]
synonym: "activation of gamma-aminobutyric acid secretion" NARROW []
synonym: "positive regulation of GABA secretion" EXACT []
synonym: "stimulation of gamma-aminobutyric acid secretion" NARROW []
synonym: "up regulation of gamma-aminobutyric acid secretion" EXACT []
synonym: "up-regulation of gamma-aminobutyric acid secretion" EXACT []
synonym: "upregulation of gamma-aminobutyric acid secretion" EXACT []
is_a: GO:0014052 ! regulation of gamma-aminobutyric acid secretion
is_a: GO:0051047 ! positive regulation of secretion
is_a: GO:0051957 ! positive regulation of amino acid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0014051 ! gamma-aminobutyric acid secretion
relationship: positively_regulates GO:0014051 ! gamma-aminobutyric acid secretion

[Term]
id: GO:0014055
name: acetylcholine secretion, neurotransmission
namespace: biological_process
def: "The regulated release of acetylcholine by a cell. The acetylcholine acts as a neurotransmitter that acts in both the peripheral nervous system (PNS) and central nervous system (CNS)." [GOC:ef]
is_a: GO:0007269 ! neurotransmitter secretion
is_a: GO:0061526 ! acetylcholine secretion
intersection_of: GO:0061526 ! acetylcholine secretion
intersection_of: part_of GO:0007271 ! synaptic transmission, cholinergic
relationship: part_of GO:0007271 ! synaptic transmission, cholinergic

[Term]
id: GO:0014056
name: regulation of acetylcholine secretion, neurotransmission
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of acetylcholine." [GOC:ef]
is_a: GO:0032222 ! regulation of synaptic transmission, cholinergic
is_a: GO:0044070 ! regulation of anion transport
is_a: GO:0046928 ! regulation of neurotransmitter secretion
is_a: GO:0051952 ! regulation of amine transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0014055 ! acetylcholine secretion, neurotransmission
relationship: regulates GO:0014055 ! acetylcholine secretion, neurotransmission

[Term]
id: GO:0014057
name: positive regulation of acetylcholine secretion, neurotransmission
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of acetylcholine." [GOC:ef]
synonym: "activation of acetylcholine secretion" NARROW []
synonym: "stimulation of acetylcholine secretion" NARROW []
synonym: "up regulation of acetylcholine secretion" EXACT []
synonym: "up-regulation of acetylcholine secretion" EXACT []
synonym: "upregulation of acetylcholine secretion" EXACT []
is_a: GO:0001956 ! positive regulation of neurotransmitter secretion
is_a: GO:0014056 ! regulation of acetylcholine secretion, neurotransmission
is_a: GO:0032224 ! positive regulation of synaptic transmission, cholinergic
is_a: GO:0051954 ! positive regulation of amine transport
is_a: GO:1903793 ! positive regulation of anion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0014055 ! acetylcholine secretion, neurotransmission
relationship: positively_regulates GO:0014055 ! acetylcholine secretion, neurotransmission

[Term]
id: GO:0014058
name: negative regulation of acetylcholine secretion, neurotransmission
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of acetylcholine." [GOC:ef]
synonym: "down regulation of acetylcholine secretion" EXACT []
synonym: "down-regulation of acetylcholine secretion" EXACT []
synonym: "downregulation of acetylcholine secretion" EXACT []
synonym: "inhibition of acetylcholine secretion" NARROW []
is_a: GO:0014056 ! regulation of acetylcholine secretion, neurotransmission
is_a: GO:0032223 ! negative regulation of synaptic transmission, cholinergic
is_a: GO:0046929 ! negative regulation of neurotransmitter secretion
is_a: GO:0051953 ! negative regulation of amine transport
is_a: GO:1903792 ! negative regulation of anion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0014055 ! acetylcholine secretion, neurotransmission
relationship: negatively_regulates GO:0014055 ! acetylcholine secretion, neurotransmission

[Term]
id: GO:0014059
name: regulation of dopamine secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of dopamine." [GOC:ef]
is_a: GO:0044070 ! regulation of anion transport
is_a: GO:0050433 ! regulation of catecholamine secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0014046 ! dopamine secretion
relationship: regulates GO:0014046 ! dopamine secretion

[Term]
id: GO:0014060
name: regulation of epinephrine secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of epinephrine." [GOC:ef]
synonym: "regulation of adrenaline secretion" EXACT []
is_a: GO:0046883 ! regulation of hormone secretion
is_a: GO:0050433 ! regulation of catecholamine secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048242 ! epinephrine secretion
relationship: regulates GO:0048242 ! epinephrine secretion

[Term]
id: GO:0014061
name: regulation of norepinephrine secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of norepinephrine." [GOC:ef]
synonym: "regulation of noradrenaline secretion" EXACT []
is_a: GO:0050433 ! regulation of catecholamine secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048243 ! norepinephrine secretion
relationship: regulates GO:0048243 ! norepinephrine secretion

[Term]
id: GO:0014062
name: regulation of serotonin secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of serotonin." [GOC:ef]
synonym: "regulation of serotonin release" RELATED [GOC:tb]
is_a: GO:0044070 ! regulation of anion transport
is_a: GO:1903530 ! regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001820 ! serotonin secretion
relationship: regulates GO:0001820 ! serotonin secretion

[Term]
id: GO:0014063
name: negative regulation of serotonin secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of serotonin." [GOC:ef]
synonym: "down regulation of serotonin secretion" EXACT []
synonym: "down-regulation of serotonin secretion" EXACT []
synonym: "downregulation of serotonin secretion" EXACT []
synonym: "inhibition of serotonin secretion" NARROW []
synonym: "positive regulation of serotonin release" RELATED [GOC:tb]
is_a: GO:0014062 ! regulation of serotonin secretion
is_a: GO:1903531 ! negative regulation of secretion by cell
is_a: GO:1903792 ! negative regulation of anion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001820 ! serotonin secretion
relationship: negatively_regulates GO:0001820 ! serotonin secretion

[Term]
id: GO:0014064
name: positive regulation of serotonin secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of serotonin." [GOC:ef]
synonym: "activation of serotonin secretion" NARROW []
synonym: "positive regulation of serotonin release" RELATED [GOC:tb]
synonym: "stimulation of serotonin secretion" NARROW []
synonym: "up regulation of serotonin secretion" EXACT []
synonym: "up-regulation of serotonin secretion" EXACT []
synonym: "upregulation of serotonin secretion" EXACT []
is_a: GO:0014062 ! regulation of serotonin secretion
is_a: GO:1903532 ! positive regulation of secretion by cell
is_a: GO:1903793 ! positive regulation of anion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001820 ! serotonin secretion
relationship: positively_regulates GO:0001820 ! serotonin secretion

[Term]
id: GO:0014065
name: phosphatidylinositol 3-kinase signaling
namespace: biological_process
def: "A series of reactions within the signal-receiving cell, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface receptor linked signaling pathways signal through PI3K to regulate numerous cellular functions." [GOC:ef, http://www.biocarta.com, PMID:22525052, Wikipedia:PI3K]
synonym: "phosphatidylinositol 3-kinase cascade" RELATED [GOC:signaling]
synonym: "phosphatidylinositol 3-kinase signal transduction" EXACT [GOC:signaling]
synonym: "phosphoinositide 3-kinase cascade" EXACT [GOC:curators]
synonym: "PI 3-kinase cascade" EXACT []
synonym: "PI3K cascade" EXACT []
synonym: "PI3K signal transduction" EXACT [GOC:signaling]
synonym: "PI3K signaling" EXACT [GOC:signaling]
is_a: GO:0048015 ! phosphatidylinositol-mediated signaling

[Term]
id: GO:0014066
name: regulation of phosphatidylinositol 3-kinase signaling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade." [GOC:ef]
synonym: "regulation of phosphatidylinositol 3-kinase cascade" RELATED []
synonym: "regulation of phosphoinositide 3-kinase cascade" EXACT [GOC:curators]
synonym: "regulation of PI 3-kinase cascade" RELATED []
synonym: "regulation of PI3K cascade" EXACT []
is_a: GO:1902531 ! regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0014065 ! phosphatidylinositol 3-kinase signaling
relationship: regulates GO:0014065 ! phosphatidylinositol 3-kinase signaling

[Term]
id: GO:0014067
name: negative regulation of phosphatidylinositol 3-kinase signaling
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade." [GOC:ef]
synonym: "down regulation of phosphatidylinositol 3-kinase cascade" EXACT []
synonym: "down-regulation of phosphatidylinositol 3-kinase cascade" EXACT []
synonym: "downregulation of phosphatidylinositol 3-kinase cascade" EXACT []
synonym: "inhibition of phosphatidylinositol 3-kinase cascade" NARROW []
synonym: "negative regulation of phosphatidylinositol 3-kinase cascade" RELATED []
synonym: "negative regulation of phosphoinositide 3-kinase cascade" EXACT [GOC:curators]
synonym: "negative regulation of PI 3-kinase cascade" EXACT []
synonym: "negative regulation of PI3K cascade" EXACT []
is_a: GO:0014066 ! regulation of phosphatidylinositol 3-kinase signaling
is_a: GO:1902532 ! negative regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0014065 ! phosphatidylinositol 3-kinase signaling
relationship: negatively_regulates GO:0014065 ! phosphatidylinositol 3-kinase signaling

[Term]
id: GO:0014068
name: positive regulation of phosphatidylinositol 3-kinase signaling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade." [GOC:ef]
synonym: "activation of phosphoinositide 3-kinase cascade" NARROW []
synonym: "positive regulation of phosphatidylinositol 3-kinase cascade" RELATED []
synonym: "positive regulation of phosphoinositide 3-kinase cascade" EXACT [GOC:curators]
synonym: "positive regulation of PI 3-kinase cascade" EXACT []
synonym: "positive regulation of PI3K cascade" EXACT []
synonym: "stimulation of phosphatidylinositol 3-kinase cascade" NARROW []
synonym: "up regulation of phosphatidylinositol 3-kinase cascade" EXACT []
synonym: "up-regulation of phosphatidylinositol 3-kinase cascade" EXACT []
synonym: "upregulation of phosphatidylinositol 3-kinase cascade" EXACT []
is_a: GO:0014066 ! regulation of phosphatidylinositol 3-kinase signaling
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0014065 ! phosphatidylinositol 3-kinase signaling
relationship: positively_regulates GO:0014065 ! phosphatidylinositol 3-kinase signaling

[Term]
id: GO:0014069
name: postsynaptic density
namespace: cellular_component
def: "The postsynaptic density is a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at an excitatory synapse. It forms a disc that consists of a range of proteins with different functions, some of which contact the cytoplasmic domains of ion channels in the postsynaptic membrane. The proteins making up the disc include structural proteins linked to the actin cytoskeleton and signalling machinery, such as protein kinases and phosphatases. The postsynaptic density may be part of a neuron or a muscle cell or a glial cell." [GOC:BHF, GOC:ef, GOC:jid, GOC:pr, GOC:sjp, http://molneuro.kaist.ac.kr/psd, PMID:14532281, Wikipedia:Postsynaptic_density]
subset: goslim_synapse
synonym: "post synaptic density" EXACT []
synonym: "post-synaptic density" EXACT []
xref: NIF_Subcellular:sao1196688972
xref: Wikipedia:Postsynaptic_density
is_a: GO:0099572 ! postsynaptic specialization
relationship: part_of GO:0060076 ! excitatory synapse

[Term]
id: GO:0014070
name: response to organic cyclic compound
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus." [CHEBI:33832, GOC:ef]
synonym: "response to organic cyclic substance" EXACT [GOC:mah]
is_a: GO:0010033 ! response to organic substance

[Term]
id: GO:0014071
name: response to cycloalkane
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cycloalkane stimulus. A cycloalkane is a cyclic saturated hydrocarbon having the general formula CnH2n." [CHEBI:23453, GOC:ef]
is_a: GO:0014070 ! response to organic cyclic compound

[Term]
id: GO:0014072
name: response to isoquinoline alkaloid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isoquinoline alkaloid stimulus. An isoquinoline alkaloid is any member of a group of compounds with the heterocyclic ring structure of benzo(c)pyridine which is a structure characteristic of the group of opium alkaloids." [CHEBI:24921, GOC:ef]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0043279 ! response to alkaloid

[Term]
id: GO:0014073
name: response to tropane
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tropane stimulus. Tropane is a nitrogenous bicyclic organic compound mainly known for a group of alkaloids derived from it (called tropane alkaloids), which include, among others, atropine and cocaine." [CHEBI:35615, GOC:ef]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0043279 ! response to alkaloid

[Term]
id: GO:0014074
name: response to purine-containing compound
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purine-containing compound stimulus." [CHEBI:26401, GOC:ef]
synonym: "response to purine" RELATED [GOC:curators]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound

[Term]
id: GO:0014075
name: response to amine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups." [CHEBI:32952, GOC:ef]
synonym: "response to amine stimulus" EXACT [GOC:dos]
is_a: GO:0010243 ! response to organonitrogen compound

[Term]
id: GO:0014076
name: response to fluoxetine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluoxetine stimulus. Fluoxetine increases the extracellular level of the neurotransmitter serotonin by inhibiting its reuptake into the presynaptic cell, increasing the level of serotonin available to bind to the postsynaptic receptor." [CHEBI:5118, GOC:ef, GOC:pr]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
synonym: "response to selective serotonin reuptake inhibitor" RELATED [GOC:curators]
synonym: "response to SSRI" RELATED [GOC:curators]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0036276 ! response to antidepressant
is_a: GO:0045472 ! response to ether

[Term]
id: GO:0014701
name: junctional sarcoplasmic reticulum membrane
namespace: cellular_component
def: "The part of the sarcoplasmic reticulum membrane that contains calcium release channels, is devoted to calcium release and is juxtaposed to transverse tubule membrane. The junctional sarcoplasmic reticulum membrane consists of the junctional region of the terminal cisterna membrane." [GOC:mtg_muscle]
is_a: GO:0033017 ! sarcoplasmic reticulum membrane

[Term]
id: GO:0014702
name: free sarcoplasmic reticulum membrane
namespace: cellular_component
def: "The part of the sarcoplasmic reticulum membrane that contains calcium pumps and is devoted to calcium uptake. The free sarcoplasmic reticulum membrane consists of the longitudinal sarcoplasmic reticulum membrane and the non-junctional region of the terminal cisterna membrane." [GOC:mtg_muscle]
is_a: GO:0033017 ! sarcoplasmic reticulum membrane

[Term]
id: GO:0014703
name: oscillatory muscle contraction
namespace: biological_process
def: "A process in which force is generated within oscillatory skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Oscillatory muscle contraction occurs in insect wing muscles and is characterized by asynchrony between action potential and contraction and by stretch activation." [GOC:mtg_muscle]
is_a: GO:0003010 ! voluntary skeletal muscle contraction

[Term]
id: GO:0014704
name: intercalated disc
namespace: cellular_component
def: "A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells." [GOC:mtg_muscle, PMID:11732910]
synonym: "intercalated disk" EXACT []
xref: Wikipedia:Intercalated_disc
is_a: GO:0044291 ! cell-cell contact zone

[Term]
id: GO:0014705
name: C zone
namespace: cellular_component
def: "A region of the A band in which myosin-binding protein C is located and that can be seen by electron microscopy. This is a functional zone that also includes myosin." [GOC:mtg_muscle]
is_a: GO:0044449 ! contractile fiber part
relationship: part_of GO:0031672 ! A band

[Term]
id: GO:0014706
name: striated muscle tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of a striated muscle over time, from its formation to the mature structure. Striated muscle contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. Skeletal muscle myoblasts fuse to form myotubes and eventually multinucleated muscle fibers. The fusion of cardiac cells is very rare and can only form binucleate cells." [CL:0000737, GOC:dph, GOC:mtg_muscle]
is_a: GO:0060537 ! muscle tissue development

[Term]
id: GO:0014707
name: branchiomeric skeletal muscle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the branchiomeric skeletal muscle over time, from its formation to the mature structure. The branchiomeric muscle is derived from cranial mesoderm and controls facial expression, pharyngeal and laryngeal function, operating the jaw. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. Branchiomeric muscles of mammals correspond to the gill musculature of fish." [GOC:mtg_muscle]
is_a: GO:0007517 ! muscle organ development
is_a: GO:0007519 ! skeletal muscle tissue development

[Term]
id: GO:0014708
name: regulation of somitomeric trunk muscle development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of somitomeric trunk muscle development." [GOC:mtg_muscle]
is_a: GO:0048641 ! regulation of skeletal muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002075 ! somitomeric trunk muscle development
relationship: regulates GO:0002075 ! somitomeric trunk muscle development

[Term]
id: GO:0014709
name: positive regulation of somitomeric trunk muscle development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of somitomeric trunk muscle development. The somitomeric trunk muscle is derived from somitomeric mesoderm. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle." [GOC:mtg_muscle]
is_a: GO:0014708 ! regulation of somitomeric trunk muscle development
is_a: GO:0048643 ! positive regulation of skeletal muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002075 ! somitomeric trunk muscle development
relationship: positively_regulates GO:0002075 ! somitomeric trunk muscle development

[Term]
id: GO:0014710
name: negative regulation of somitomeric trunk muscle development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of somitomeric trunk muscle development. The somitomeric trunk muscle is derived from somitomeric mesoderm. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle." [GOC:mtg_muscle]
is_a: GO:0014708 ! regulation of somitomeric trunk muscle development
is_a: GO:0048642 ! negative regulation of skeletal muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002075 ! somitomeric trunk muscle development
relationship: negatively_regulates GO:0002075 ! somitomeric trunk muscle development

[Term]
id: GO:0014711
name: regulation of branchiomeric skeletal muscle development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of branchiomeric skeletal muscle development. Branchiomeric skeletal muscle development is the process whose specific outcome is the progression of the branchiomeric skeletal muscle over time, from its formation to the mature structure." [GOC:mtg_muscle]
is_a: GO:0048641 ! regulation of skeletal muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0014707 ! branchiomeric skeletal muscle development
relationship: regulates GO:0014707 ! branchiomeric skeletal muscle development

[Term]
id: GO:0014712
name: positive regulation of branchiomeric skeletal muscle development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of branchiomeric skeletal muscle development. Branchiomeric skeletal muscle development is the process whose specific outcome is the progression of the branchiomeric skeletal muscle over time, from its formation to the mature structure." [GOC:mtg_muscle]
is_a: GO:0014711 ! regulation of branchiomeric skeletal muscle development
is_a: GO:0048643 ! positive regulation of skeletal muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0014707 ! branchiomeric skeletal muscle development
relationship: positively_regulates GO:0014707 ! branchiomeric skeletal muscle development

[Term]
id: GO:0014713
name: negative regulation of branchiomeric skeletal muscle development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of branchiomeric skeletal muscle development. Branchiomeric skeletal muscle development is the process whose specific outcome is the progression of the branchiomeric skeletal muscle over time, from its formation to the mature structure." [GOC:mtg_muscle]
is_a: GO:0014711 ! regulation of branchiomeric skeletal muscle development
is_a: GO:0048642 ! negative regulation of skeletal muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0014707 ! branchiomeric skeletal muscle development
relationship: negatively_regulates GO:0014707 ! branchiomeric skeletal muscle development

[Term]
id: GO:0014714
name: myoblast fate commitment in head
namespace: biological_process
def: "The process, taking place in the head, whereby the developmental fate of a cell becomes restricted such that it will develop into a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle]
is_a: GO:0048625 ! myoblast fate commitment

[Term]
id: GO:0014715
name: myoblast fate commitment in trunk
namespace: biological_process
def: "The process taking place in the trunk whereby the developmental fate of a cell becomes restricted such that it will develop into a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle]
is_a: GO:0048625 ! myoblast fate commitment

[Term]
id: GO:0014716
name: skeletal muscle satellite stem cell asymmetric division involved in skeletal muscle regeneration
namespace: biological_process
def: "Skeletal muscle satellite cell asymmetric division that occurs during a process in which damaged muscle tissue is being rebuilt." [GOC:mtg_muscle]
comment: Occurrence of this process outside of the context of muscle repair is probably very rare, so there is a good case for merging this with the parent class.
synonym: "satellite cell asymmetric division involved in skeletal muscle regeneration" EXACT []
is_a: GO:0014833 ! skeletal muscle satellite stem cell asymmetric division
intersection_of: GO:0014833 ! skeletal muscle satellite stem cell asymmetric division
intersection_of: part_of GO:0043403 ! skeletal muscle tissue regeneration
relationship: part_of GO:0014834 ! skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
relationship: part_of GO:0043403 ! skeletal muscle tissue regeneration

[Term]
id: GO:0014717
name: regulation of satellite cell activation involved in skeletal muscle regeneration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of satellite cell activation. The satellite cell activation is the process that initiates satellite cell division by causing it to move from quiescence to the G1 stage of the cell cycle. The cell swells and there are a number of other small changes. The cells then start to divide. Following cell division the cells will differentiate." [GOC:mtg_muscle]
is_a: GO:0043416 ! regulation of skeletal muscle tissue regeneration
is_a: GO:0050865 ! regulation of cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0014901 ! satellite cell activation involved in skeletal muscle regeneration
relationship: regulates GO:0014901 ! satellite cell activation involved in skeletal muscle regeneration

[Term]
id: GO:0014718
name: positive regulation of satellite cell activation involved in skeletal muscle regeneration
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of activation of satellite cell involved in skeletal muscle regeneration. The activation of satellite cell is the process that initiates satellite cell division by causing it to move from quiescence to the G1 stage of the cell cycle. The cell swells and there are a number of other small changes. The cells then start to divide. Following cell division the cells will differentiate." [GOC:mtg_muscle]
is_a: GO:0014717 ! regulation of satellite cell activation involved in skeletal muscle regeneration
is_a: GO:0043415 ! positive regulation of skeletal muscle tissue regeneration
is_a: GO:0050867 ! positive regulation of cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0014901 ! satellite cell activation involved in skeletal muscle regeneration
relationship: positively_regulates GO:0014901 ! satellite cell activation involved in skeletal muscle regeneration

[Term]
id: GO:0014719
name: skeletal muscle satellite cell activation
namespace: biological_process
def: "The change of a skeletal muscle satellite cell from a mitotically quiescent to a mitotically active state following exposure to some activating factor  such as a cellular or soluble ligand. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage." [GOC:mtg_muscle, PMID:23303905]
is_a: GO:0001775 ! cell activation

[Term]
id: GO:0014720
name: tonic skeletal muscle contraction
namespace: biological_process
def: "A process in which force is generated within tonic skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The tonic skeletal muscle is characterized by long lasting contractile responses and high resistance to fatigue." [GOC:mtg_muscle]
is_a: GO:0003010 ! voluntary skeletal muscle contraction

[Term]
id: GO:0014721
name: twitch skeletal muscle contraction
namespace: biological_process
def: "A process in which force is generated within twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The twitch skeletal muscle responds to neurostimulations with a contraction followed by a relaxation." [GOC:mtg_muscle]
is_a: GO:0003010 ! voluntary skeletal muscle contraction

[Term]
id: GO:0014722
name: regulation of skeletal muscle contraction by calcium ion signaling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by changing the calcium ion signals that trigger contraction." [GOC:mtg_muscle]
synonym: "regulation of skeletal muscle contraction by calcium ion signalling" EXACT []
is_a: GO:0014819 ! regulation of skeletal muscle contraction
is_a: GO:0019722 ! calcium-mediated signaling
intersection_of: GO:0019722 ! calcium-mediated signaling
intersection_of: regulates GO:0003009 ! skeletal muscle contraction
relationship: regulates GO:0003009 ! skeletal muscle contraction

[Term]
id: GO:0014723
name: regulation of skeletal muscle contraction by modulation of calcium ion sensitivity of myofibril
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by changing calcium ion binding affinity of the myofibril." [GOC:mtg_muscle]
synonym: "regulation of calcium ion sensitivity of myofibril involved in skeletal muscle contraction" EXACT []
is_a: GO:0014722 ! regulation of skeletal muscle contraction by calcium ion signaling

[Term]
id: GO:0014724
name: regulation of twitch skeletal muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of twitch skeletal muscle contraction." [GOC:mtg_muscle]
is_a: GO:0014819 ! regulation of skeletal muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0014721 ! twitch skeletal muscle contraction
relationship: regulates GO:0014721 ! twitch skeletal muscle contraction

[Term]
id: GO:0014725
name: regulation of extraocular skeletal muscle development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of extraocular skeletal muscle development. Extraocular skeletal muscle development is the process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle." [GOC:mtg_muscle]
is_a: GO:0048641 ! regulation of skeletal muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002074 ! extraocular skeletal muscle development
relationship: regulates GO:0002074 ! extraocular skeletal muscle development

[Term]
id: GO:0014726
name: negative regulation of extraocular skeletal muscle development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of extraocular skeletal muscle development. Extraocular skeletal muscle development is the process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle." [GOC:mtg_muscle]
is_a: GO:0014725 ! regulation of extraocular skeletal muscle development
is_a: GO:0048642 ! negative regulation of skeletal muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002074 ! extraocular skeletal muscle development
relationship: negatively_regulates GO:0002074 ! extraocular skeletal muscle development

[Term]
id: GO:0014727
name: positive regulation of extraocular skeletal muscle development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of extraocular skeletal muscle development. Extraocular skeletal muscle development is the process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle." [GOC:mtg_muscle]
is_a: GO:0014725 ! regulation of extraocular skeletal muscle development
is_a: GO:0048643 ! positive regulation of skeletal muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002074 ! extraocular skeletal muscle development
relationship: positively_regulates GO:0002074 ! extraocular skeletal muscle development

[Term]
id: GO:0014728
name: regulation of the force of skeletal muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the force of skeletal muscle contraction. The force of skeletal muscle contraction is produced by acto-myosin interaction processes through the formation of cross bridges." [GOC:mtg_muscle]
is_a: GO:0014862 ! regulation of skeletal muscle contraction by chemo-mechanical energy conversion

[Term]
id: GO:0014729
name: regulation of the velocity of shortening of skeletal muscle modulating contraction
namespace: biological_process
def: "Any process that modulates velocity of shortening of a skeletal muscle contraction. The shortening leads to reduction of the length of muscle fibers and sarcomeres." [GOC:mtg_muscle]
synonym: "regulation of the velocity of shortening of skeletal muscle during contraction" RELATED [GOC:dph]
is_a: GO:0014862 ! regulation of skeletal muscle contraction by chemo-mechanical energy conversion
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0014730
name: skeletal muscle regeneration at neuromuscular junction
namespace: biological_process
def: "The regrowth of muscle tissue to repair injured or damaged muscle fibers in the postnatal stage at the neuromuscular junction. Regeneration of neuromuscular junctions occurs in an orderly way and relies on communication between nerve and muscle. Skeletal myofibers regenerate after injury and form neuro-muscular junctions with motor axons similar to normal ones. Regenerating myofibers develop within the basal lamina sheaths (satellite cells) of original myofibers." [GOC:mtg_muscle]
is_a: GO:0043403 ! skeletal muscle tissue regeneration

[Term]
id: GO:0014731
name: spectrin-associated cytoskeleton
namespace: cellular_component
def: "The part of the cytoskeleton composed of spectrin, protein 4.1 and ankyrin. Spectrin-associated cytoskeleton is associated with the plasma membrane." [GOC:mtg_muscle, PMID:15970557]
is_a: GO:0005856 ! cytoskeleton

[Term]
id: GO:0014732
name: skeletal muscle atrophy
namespace: biological_process
def: "A process, occurring in skeletal muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse." [GOC:mtg_muscle]
is_a: GO:0014891 ! striated muscle atrophy
is_a: GO:0043501 ! skeletal muscle adaptation

[Term]
id: GO:0014733
name: regulation of skeletal muscle adaptation
namespace: biological_process
def: "Any process in which skeletal muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle]
synonym: "regulation of skeletal muscle plasticity" RELATED []
is_a: GO:0043502 ! regulation of muscle adaptation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043501 ! skeletal muscle adaptation
relationship: regulates GO:0043501 ! skeletal muscle adaptation

[Term]
id: GO:0014734
name: skeletal muscle hypertrophy
namespace: biological_process
def: "The enlargement or overgrowth of all or part of an organ due to an increase in size (not length) of individual muscle fibers without cell division. In the case of skeletal muscle cells this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils." [GOC:mtg_muscle]
is_a: GO:0014897 ! striated muscle hypertrophy
is_a: GO:0043501 ! skeletal muscle adaptation

[Term]
id: GO:0014735
name: regulation of muscle atrophy
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of muscle atrophy." [GOC:mtg_muscle]
is_a: GO:0043502 ! regulation of muscle adaptation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0014889 ! muscle atrophy
relationship: regulates GO:0014889 ! muscle atrophy

[Term]
id: GO:0014736
name: negative regulation of muscle atrophy
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle atrophy." [GOC:mtg_muscle]
is_a: GO:0014735 ! regulation of muscle atrophy
is_a: GO:0014745 ! negative regulation of muscle adaptation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0014889 ! muscle atrophy
relationship: negatively_regulates GO:0014889 ! muscle atrophy

[Term]
id: GO:0014737
name: positive regulation of muscle atrophy
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of muscle atrophy." [GOC:mtg_muscle]
is_a: GO:0014735 ! regulation of muscle atrophy
is_a: GO:0014744 ! positive regulation of muscle adaptation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0014889 ! muscle atrophy
relationship: positively_regulates GO:0014889 ! muscle atrophy

[Term]
id: GO:0014738
name: regulation of muscle hyperplasia
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of muscle hyperplasia." [GOC:mtg_muscle]
is_a: GO:0043502 ! regulation of muscle adaptation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0014900 ! muscle hyperplasia
relationship: regulates GO:0014900 ! muscle hyperplasia

[Term]
id: GO:0014739
name: positive regulation of muscle hyperplasia
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of muscle hyperplasia." [GOC:mtg_muscle]
is_a: GO:0014738 ! regulation of muscle hyperplasia
is_a: GO:0014744 ! positive regulation of muscle adaptation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0014900 ! muscle hyperplasia
relationship: positively_regulates GO:0014900 ! muscle hyperplasia

[Term]
id: GO:0014740
name: negative regulation of muscle hyperplasia
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hyperplasia." [GOC:mtg_muscle]
is_a: GO:0014738 ! regulation of muscle hyperplasia
is_a: GO:0014745 ! negative regulation of muscle adaptation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0014900 ! muscle hyperplasia
relationship: negatively_regulates GO:0014900 ! muscle hyperplasia

[Term]
id: GO:0014741
name: negative regulation of muscle hypertrophy
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hypertrophy." [GOC:mtg_muscle]
is_a: GO:0014743 ! regulation of muscle hypertrophy
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0014896 ! muscle hypertrophy
relationship: negatively_regulates GO:0014896 ! muscle hypertrophy

[Term]
id: GO:0014742
name: positive regulation of muscle hypertrophy
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of muscle hypertrophy." [GOC:mtg_muscle]
is_a: GO:0014743 ! regulation of muscle hypertrophy
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0014896 ! muscle hypertrophy
relationship: positively_regulates GO:0014896 ! muscle hypertrophy

[Term]
id: GO:0014743
name: regulation of muscle hypertrophy
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of muscle hypertrophy." [GOC:mtg_muscle]
is_a: GO:0090257 ! regulation of muscle system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0014896 ! muscle hypertrophy
relationship: regulates GO:0014896 ! muscle hypertrophy

[Term]
id: GO:0014744
name: positive regulation of muscle adaptation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of muscle adaptation." [GOC:mtg_muscle]
synonym: "positive regulation of muscle plasticity" RELATED []
is_a: GO:0043502 ! regulation of muscle adaptation
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043500 ! muscle adaptation
relationship: positively_regulates GO:0043500 ! muscle adaptation

[Term]
id: GO:0014745
name: negative regulation of muscle adaptation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle adaptation." [GOC:mtg_muscle]
synonym: "negative regulation of muscle plasticity" RELATED []
is_a: GO:0043502 ! regulation of muscle adaptation
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043500 ! muscle adaptation
relationship: negatively_regulates GO:0043500 ! muscle adaptation

[Term]
id: GO:0014746
name: regulation of tonic skeletal muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tonic skeletal muscle contraction." [GOC:mtg_muscle]
is_a: GO:0014819 ! regulation of skeletal muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0014720 ! tonic skeletal muscle contraction
relationship: regulates GO:0014720 ! tonic skeletal muscle contraction

[Term]
id: GO:0014747
name: positive regulation of tonic skeletal muscle contraction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tonic skeletal muscle contraction." [GOC:ef, GOC:mtg_muscle]
is_a: GO:0014746 ! regulation of tonic skeletal muscle contraction
is_a: GO:0045989 ! positive regulation of striated muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0014720 ! tonic skeletal muscle contraction
relationship: positively_regulates GO:0014720 ! tonic skeletal muscle contraction

[Term]
id: GO:0014748
name: negative regulation of tonic skeletal muscle contraction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of tonic skeletal muscle contraction." [GOC:ef, GOC:mtg_muscle]
is_a: GO:0014746 ! regulation of tonic skeletal muscle contraction
is_a: GO:0045988 ! negative regulation of striated muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0014720 ! tonic skeletal muscle contraction
relationship: negatively_regulates GO:0014720 ! tonic skeletal muscle contraction

[Term]
id: GO:0014801
name: longitudinal sarcoplasmic reticulum
namespace: cellular_component
def: "The portion of the free sarcoplasmic reticulum consisting of longitudinal tubules that connect terminal cisternae." [GOC:mtg_muscle]
is_a: GO:0044432 ! endoplasmic reticulum part
relationship: part_of GO:0016529 ! sarcoplasmic reticulum

[Term]
id: GO:0014802
name: terminal cisterna
namespace: cellular_component
def: "The portion of sarcoplasmic reticulum devoted to calcium ion storage and calcium ion release." [GOC:mtg_muscle]
xref: Wikipedia:Terminal_cisterna
is_a: GO:0098827 ! endoplasmic reticulum subcompartment
relationship: part_of GO:0016529 ! sarcoplasmic reticulum

[Term]
id: GO:0014803
name: longitudinal sarcoplasmic reticulum lumen
namespace: cellular_component
def: "The region between the inner and outer lipid bilayers of the longitudinal sarcoplasmic reticulum envelope. The longitudinal sarcoplasmic reticulum lumen is continuous with the lumen contained within the terminal cisternae." [GOC:mtg_muscle]
is_a: GO:0033018 ! sarcoplasmic reticulum lumen
relationship: part_of GO:0014801 ! longitudinal sarcoplasmic reticulum

[Term]
id: GO:0014804
name: terminal cisterna lumen
namespace: cellular_component
def: "The region between the inner and outer lipid bilayers of the terminal cisterna envelope. This space is enriched in calsequestrin." [GOC:mtg_muscle]
is_a: GO:0033018 ! sarcoplasmic reticulum lumen
relationship: part_of GO:0014802 ! terminal cisterna

[Term]
id: GO:0014805
name: smooth muscle adaptation
namespace: biological_process
def: "Any process in which smooth muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle]
synonym: "smooth muscle plasticity" RELATED []
is_a: GO:0043500 ! muscle adaptation

[Term]
id: GO:0014806
name: smooth muscle hyperplasia
namespace: biological_process
def: "A process, occurring in smooth muscle, in which there is an increase in cell number by cell division, often leading to an increase in the size of an organ." [GOC:mtg_muscle]
is_a: GO:0014805 ! smooth muscle adaptation
is_a: GO:0014900 ! muscle hyperplasia

[Term]
id: GO:0014807
name: regulation of somitogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of somitogenesis." [GOC:mtg_muscle]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0045995 ! regulation of embryonic development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001756 ! somitogenesis
relationship: regulates GO:0001756 ! somitogenesis

[Term]
id: GO:0014808
name: release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
namespace: biological_process
def: "The process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels." [GOC:mtg_muscle]
synonym: "release of sequestered calcium ion by sarcoplasmic reticulum into cytosol" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051209 ! release of sequestered calcium ion into cytosol
is_a: GO:0070296 ! sarcoplasmic reticulum calcium ion transport
is_a: GO:1903514 ! calcium ion transport from endoplasmic reticulum to cytosol

[Term]
id: GO:0014809
name: regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction." [GOC:mtg_muscle]
is_a: GO:0010880 ! regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
is_a: GO:0014722 ! regulation of skeletal muscle contraction by calcium ion signaling

[Term]
id: GO:0014810
name: positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of skeletal muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction." [GOC:mtg_muscle]
is_a: GO:0014809 ! regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
is_a: GO:0045989 ! positive regulation of striated muscle contraction

[Term]
id: GO:0014811
name: negative regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction." [GOC:mtg_muscle]
is_a: GO:0014809 ! regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
is_a: GO:0045988 ! negative regulation of striated muscle contraction

[Term]
id: GO:0014812
name: muscle cell migration
namespace: biological_process
def: "The orderly movement of a muscle cell from one site to another, often during the development of a multicellular organism." [CL:0000187, GOC:mtg_muscle]
is_a: GO:0016477 ! cell migration

[Term]
id: GO:0014813
name: skeletal muscle satellite cell commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a satellite cell." [GOC:ef, GOC:mtg_muscle, PMID:16607119]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0014816 ! skeletal muscle satellite cell differentiation

[Term]
id: GO:0014814
name: axon regeneration at neuromuscular junction
namespace: biological_process
def: "The regrowth of axons following their loss or damage at the neuromuscular junction. Motor axons regenerate after injury and they form neuro-muscular junctions with skeletal myofibers similar to normal ones." [GOC:ef, GOC:mtg_muscle]
is_a: GO:0031103 ! axon regeneration

[Term]
id: GO:0014815
name: initiation of skeletal muscle satellite cell activation by growth factor signalling, involved in skeletal muscle regeneration
namespace: biological_process
def: "Signalling between growth factors and their receptors that results in the activation of satellite cell, where this process is involved in skeletal muscle regeneration. Satellite cells are quiescent cells that are located between the basal lamina and the plasmalemma of the muscle fiber, which are the main contributors to postnatal muscle growth. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage." [GOC:ef, GOC:mtg_muscle, PMID:16607119]
is_a: GO:0014718 ! positive regulation of satellite cell activation involved in skeletal muscle regeneration

[Term]
id: GO:0014816
name: skeletal muscle satellite cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a satellite cell." [GOC:ef, GOC:mtg_muscle, PMID:16607119]
is_a: GO:0035914 ! skeletal muscle cell differentiation
relationship: part_of GO:0007519 ! skeletal muscle tissue development

[Term]
id: GO:0014817
name: skeletal muscle satellite cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a skeletal muscle satellite cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:ef, GOC:mtg_muscle, PMID:16607119]
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0014813 ! skeletal muscle satellite cell commitment

[Term]
id: GO:0014818
name: skeletal muscle satellite cell fate determination
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a skeletal muscle satellite cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:ef, GOC:mtg_muscle, PMID:16607119]
is_a: GO:0048867 ! stem cell fate determination
relationship: part_of GO:0014813 ! skeletal muscle satellite cell commitment

[Term]
id: GO:0014819
name: regulation of skeletal muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction." [GOC:ef, GOC:mtg_muscle]
is_a: GO:0006942 ! regulation of striated muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003009 ! skeletal muscle contraction
relationship: regulates GO:0003009 ! skeletal muscle contraction

[Term]
id: GO:0014820
name: tonic smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within tonic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the tonic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Tonic smooth muscle contraction occurs as a sustained continuous contraction." [GOC:mtg_muscle]
is_a: GO:0006939 ! smooth muscle contraction

[Term]
id: GO:0014821
name: phasic smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within phasic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the phasic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Phasic smooth muscle contraction occurs in a series of discrete contractions and relaxations." [GOC:mtg_muscle]
is_a: GO:0006939 ! smooth muscle contraction

[Term]
id: GO:0014822
name: detection of wounding
namespace: biological_process
def: "The series of events by which an injury stimulus is received and converted into a molecular signal." [GOC:mtg_muscle]
synonym: "detection of injury" EXACT []
is_a: GO:0009581 ! detection of external stimulus
is_a: GO:0009611 ! response to wounding

[Term]
id: GO:0014823
name: response to activity
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus." [GOC:mtg_muscle]
synonym: "response to exercise" RELATED []
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0014824
name: artery smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the artery. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The artery is a vessel carrying blood away from the heart." [GOC:mtg_muscle, MA:0000708, MSH:D001158]
is_a: GO:0014820 ! tonic smooth muscle contraction
is_a: GO:0014829 ! vascular smooth muscle contraction

[Term]
id: GO:0014825
name: stomach fundus smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the fundus of stomach. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The fundus is the portion of the stomach that lies above the cardiac notch." [GOC:mtg_muscle, MA:0001612]
is_a: GO:0014847 ! proximal stomach smooth muscle contraction

[Term]
id: GO:0014826
name: vein smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the vein. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The vein is a vessel carrying blood away from the capillary beds." [GOC:mtg_muscle, MA:0000715, MSH:D014680]
is_a: GO:0014821 ! phasic smooth muscle contraction
is_a: GO:0014829 ! vascular smooth muscle contraction

[Term]
id: GO:0014827
name: intestine smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the intestine. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The intestine is the section of the alimentary canal from the stomach to the anal canal. It includes the large intestine and small intestine." [GOC:mtg_muscle, MA:0001539, MSH:D007422]
is_a: GO:0014821 ! phasic smooth muscle contraction
is_a: GO:0014831 ! gastro-intestinal system smooth muscle contraction

[Term]
id: GO:0014828
name: distal stomach smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the distal stomach. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The distal stomach is composed of the lower body and antrum and develops strong peristaltic phasic contractions that increase in amplitude as they propagate toward the pylorus." [GOC:mtg_muscle, http://biology.about.com]
is_a: GO:0014821 ! phasic smooth muscle contraction
is_a: GO:0014831 ! gastro-intestinal system smooth muscle contraction

[Term]
id: GO:0014829
name: vascular smooth muscle contraction
namespace: biological_process
def: "A process, occurring in the vascular tissue, whereby actin/myosin complex activity generates force through ATP hydrolysis resulting in a change in smooth muscle geometry. This process is always coupled to chemo-mechanical energy conversion." [GOC:mtg_muscle, MA:0002718]
is_a: GO:0006939 ! smooth muscle contraction
is_a: GO:0042310 ! vasoconstriction

[Term]
id: GO:0014830
name: arteriole smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the arteriole. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The arteriole is the smallest division of the artery located between the muscular arteries and the capillaries." [GOC:mtg_muscle, MA:0000706, MSH:D001160]
is_a: GO:0014824 ! artery smooth muscle contraction

[Term]
id: GO:0014831
name: gastro-intestinal system smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the gastro-intestinal system. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The gastro-intestinal system generally refers to the digestive structures stretching from the mouth to anus, but does not include the accessory glandular organs (liver, pancreas and biliary tract)." [GOC:mtg_muscle, MA:0001523, MSH:D041981]
is_a: GO:0006939 ! smooth muscle contraction

[Term]
id: GO:0014832
name: urinary bladder smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the urinary bladder. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The urinary bladder is a musculomembranous sac along the urinary tract." [GOC:mr, GOC:mtg_muscle, http://en.wikipedia.org/wiki/Rhea_(bird), MA:0001697, MSH:D001743, PMID:11768524, PMID:18276178, PMID:538956]
is_a: GO:0014848 ! urinary tract smooth muscle contraction

[Term]
id: GO:0014833
name: skeletal muscle satellite stem cell asymmetric division
namespace: biological_process
def: "The asymmetric division of a skeletal muscle satellite stem cell to produce two daughter cells, one of which is destined to differentiate and the other to be a quiescent cell that restocks the satellite cell pool." [GOC:ef, GOC:mtg_muscle, PMID:16607119]
synonym: "satellite cell asymmetric division" EXACT []
is_a: GO:0098722 ! asymmetric stem cell division
relationship: part_of GO:0007519 ! skeletal muscle tissue development

[Term]
id: GO:0014834
name: skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
namespace: biological_process
def: "Any process by which the number of skeletal muscle satellite cells in a skeletal muscle is maintained during muscle regeneration. There are at least three mechanisms by which this is achieved. Skeletal muscle satellite stem cell asymmetric division ensures satellite stem cell numbers are kept constant. Symmetric division of these cells amplifies the number of skeletal muscle satellite stem cells.  Some adult skeletal muscle myoblasts (descendants of activated satellite cells) can develop back into quiescent satellite cells, replenishing the overall pool of satellite cells." [GOC:dph, GOC:ef, GOC:mtg_muscle, GOC:tb, PMID:23303905]
synonym: "satellite cell compartment self-renewal involved in skeletal muscle regeneration" EXACT [GOC:dph, GOC:tb]
synonym: "satellite cell population maintenance" EXACT []
synonym: "satellite cell self-renewal" BROAD []
is_a: GO:0098727 ! maintenance of cell number
relationship: part_of GO:0043403 ! skeletal muscle tissue regeneration

[Term]
id: GO:0014835
name: myoblast differentiation involved in skeletal muscle regeneration
namespace: biological_process
def: "The process in which a relatively unspecialized satellite cell acquires specialized features of a myoblast. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119]
is_a: GO:0045445 ! myoblast differentiation
intersection_of: GO:0045445 ! myoblast differentiation
intersection_of: part_of GO:0043403 ! skeletal muscle tissue regeneration
relationship: part_of GO:0043403 ! skeletal muscle tissue regeneration

[Term]
id: GO:0014836
name: myoblast fate commitment involved in skeletal muscle regeneration
namespace: biological_process
def: "The process in which the developmental fate of a satellite cell becomes restricted such that it will develop into a myoblast. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119]
is_a: GO:0048625 ! myoblast fate commitment
intersection_of: GO:0048625 ! myoblast fate commitment
intersection_of: part_of GO:0043403 ! skeletal muscle tissue regeneration
relationship: part_of GO:0014835 ! myoblast differentiation involved in skeletal muscle regeneration
relationship: part_of GO:0043403 ! skeletal muscle tissue regeneration

[Term]
id: GO:0014837
name: myoblast fate determination involved in skeletal muscle regeneration
namespace: biological_process
def: "The process in which a satellite cell becomes capable of differentiating autonomously into a myoblast regardless of its environment; upon determination, the cell fate cannot be reversed. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119]
is_a: GO:0007518 ! myoblast fate determination
intersection_of: GO:0007518 ! myoblast fate determination
intersection_of: part_of GO:0043403 ! skeletal muscle tissue regeneration
relationship: part_of GO:0014836 ! myoblast fate commitment involved in skeletal muscle regeneration
relationship: part_of GO:0043403 ! skeletal muscle tissue regeneration

[Term]
id: GO:0014838
name: myoblast fate specification involved in skeletal muscle regeneration
namespace: biological_process
def: "The process in which a satellite cell becomes capable of differentiating autonomously into a myoblast in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119]
is_a: GO:0048626 ! myoblast fate specification
intersection_of: GO:0048626 ! myoblast fate specification
intersection_of: part_of GO:0043403 ! skeletal muscle tissue regeneration
relationship: part_of GO:0014836 ! myoblast fate commitment involved in skeletal muscle regeneration
relationship: part_of GO:0043403 ! skeletal muscle tissue regeneration

[Term]
id: GO:0014839
name: myoblast migration involved in skeletal muscle regeneration
namespace: biological_process
def: "The process in which a myoblast migrates along an entire fiber to the site of injury. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119]
synonym: "mononucleate cell migration involved in skeletal muscle regeneration" BROAD []
is_a: GO:0051451 ! myoblast migration
intersection_of: GO:0051451 ! myoblast migration
intersection_of: part_of GO:0043403 ! skeletal muscle tissue regeneration
relationship: part_of GO:0043403 ! skeletal muscle tissue regeneration

[Term]
id: GO:0014841
name: skeletal muscle satellite cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of satellite cells, resulting in the expansion of the cell population. Satellite cells are quiescent cells that are located between the basal lamina and the plasmalemma of the muscle fiber, which are the main contributors to postnatal muscle growth. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage." [GOC:ef, GOC:mtg_muscle, PMID:16607119]
is_a: GO:0014856 ! skeletal muscle cell proliferation

[Term]
id: GO:0014842
name: regulation of skeletal muscle satellite cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle satellite cell proliferation." [GOC:ef, GOC:mtg_muscle, PMID:16607119]
is_a: GO:0014857 ! regulation of skeletal muscle cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0014841 ! skeletal muscle satellite cell proliferation
relationship: regulates GO:0014841 ! skeletal muscle satellite cell proliferation

[Term]
id: GO:0014843
name: growth factor dependent regulation of skeletal muscle satellite cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of satellite cell proliferation; dependent on specific growth factor activity such as fibroblast growth factors and transforming growth factor beta." [GOC:ef, GOC:mtg_muscle, PMID:16607119]
is_a: GO:0014842 ! regulation of skeletal muscle satellite cell proliferation

[Term]
id: GO:0014844
name: myoblast proliferation involved in skeletal muscle regeneration
namespace: biological_process
def: "The multiplication or reproduction of myoblasts, resulting in the expansion of the cell population. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119]
is_a: GO:0051450 ! myoblast proliferation
relationship: part_of GO:0043403 ! skeletal muscle tissue regeneration

[Term]
id: GO:0014845
name: stomach body smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the body of stomach. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The body of stomach is the part of the stomach that lies between the fundus above and the pyloric antrum below; its boundaries are poorly defined." [GOC:ef, GOC:mtg_muscle, MA:0002559]
is_a: GO:0014828 ! distal stomach smooth muscle contraction

[Term]
id: GO:0014846
name: esophagus smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the esophagus. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The esophagus is the muscular membranous segment between the pharynx and the stomach in the upper gastrointestinal tract." [GOC:ef, GOC:mtg_muscle, MA:0001573, MSH:D041742]
synonym: "oesophagus smooth muscle contraction" RELATED [GOC:dph]
is_a: GO:0014831 ! gastro-intestinal system smooth muscle contraction

[Term]
id: GO:0014847
name: proximal stomach smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the proximal stomach. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The proximal stomach, composed of the fundus and upper body, shows low frequency, sustained tonic contractions that are responsible for generating a basal pressure within the stomach." [GOC:mtg_muscle, http://biology.about.com]
is_a: GO:0014820 ! tonic smooth muscle contraction
is_a: GO:0014831 ! gastro-intestinal system smooth muscle contraction

[Term]
id: GO:0014848
name: urinary tract smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the urinary tract. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The urinary tract consists of organs of the body that produce and discharge urine. These include the kidneys, ureters, bladder, and urethra." [GOC:ef, GOC:mtg_muscle, MA:0000325, MSH:D014551]
is_a: GO:0006939 ! smooth muscle contraction

[Term]
id: GO:0014849
name: ureter smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the ureter. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The ureter is one of a pair of thick-walled tubes that transports urine from the kidney pelvis to the urinary bladder." [GOC:mtg_muscle, MA:0000378]
is_a: GO:0014821 ! phasic smooth muscle contraction
is_a: GO:0014848 ! urinary tract smooth muscle contraction

[Term]
id: GO:0014850
name: response to muscle activity
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus." [GOC:mtg_muscle]
is_a: GO:0014823 ! response to activity

[Term]
id: GO:0014852
name: regulation of skeletal muscle contraction by neural stimulation via neuromuscular junction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by variation of the pattern of stimulation by nervous system." [GOC:ef, GOC:mtg_muscle]
is_a: GO:0014819 ! regulation of skeletal muscle contraction

[Term]
id: GO:0014853
name: regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction
namespace: biological_process
def: "Any process, involved in skeletal muscle contraction, that modulates the establishment or extent of the excitatory postsynaptic potential (EPSP). Excitatory postsynaptic potential (EPSP) is a temporay increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." [GOC:ef, GOC:mtg_muscle]
synonym: "regulation of excitatory post-synaptic membrane potential involved in skeletal muscle contraction" EXACT []
is_a: GO:0098815 ! modulation of excitatory postsynaptic potential
intersection_of: GO:0098815 ! modulation of excitatory postsynaptic potential
intersection_of: part_of GO:0003009 ! skeletal muscle contraction
relationship: part_of GO:0003009 ! skeletal muscle contraction
relationship: part_of GO:0014852 ! regulation of skeletal muscle contraction by neural stimulation via neuromuscular junction

[Term]
id: GO:0014854
name: response to inactivity
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inactivity stimulus." [GOC:mtg_muscle]
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0014855
name: striated muscle cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of striated muscle cells, resulting in the expansion of a cell population. Striated muscles contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle." [CL:0000737, GOC:ef, GOC:mtg_muscle]
is_a: GO:0033002 ! muscle cell proliferation

[Term]
id: GO:0014856
name: skeletal muscle cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of skeletal muscle cells, resulting in the expansion of a cell population." [CL:0000188, GOC:ef, GOC:mtg_muscle]
is_a: GO:0014855 ! striated muscle cell proliferation

[Term]
id: GO:0014857
name: regulation of skeletal muscle cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle cell proliferation." [CL:0000188, GOC:ef, GOC:mtg_muscle]
is_a: GO:0042127 ! regulation of cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0014856 ! skeletal muscle cell proliferation
relationship: regulates GO:0014856 ! skeletal muscle cell proliferation

[Term]
id: GO:0014858
name: positive regulation of skeletal muscle cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of skeletal muscle cell proliferation." [CL:0000188, GOC:ef, GOC:mtg_muscle]
is_a: GO:0008284 ! positive regulation of cell proliferation
is_a: GO:0014857 ! regulation of skeletal muscle cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0014856 ! skeletal muscle cell proliferation
relationship: positively_regulates GO:0014856 ! skeletal muscle cell proliferation

[Term]
id: GO:0014859
name: negative regulation of skeletal muscle cell proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle cell proliferation." [CL:0000188, GOC:ef, GOC:mtg_muscle]
is_a: GO:0008285 ! negative regulation of cell proliferation
is_a: GO:0014857 ! regulation of skeletal muscle cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0014856 ! skeletal muscle cell proliferation
relationship: negatively_regulates GO:0014856 ! skeletal muscle cell proliferation

[Term]
id: GO:0014860
name: neurotransmitter secretion involved in regulation of skeletal muscle contraction
namespace: biological_process
def: "The regulated release of neurotransmitter into the synaptic cleft involved in skeletal muscle contraction. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [GOC:dph, GOC:mtg_muscle, GOC:tb]
synonym: "neurotransmitter secretion involved in control of skeletal muscle contraction" EXACT [GOC:dph, GOC:tb]
is_a: GO:0007269 ! neurotransmitter secretion
intersection_of: GO:0007269 ! neurotransmitter secretion
intersection_of: part_of GO:0014819 ! regulation of skeletal muscle contraction
relationship: part_of GO:0014819 ! regulation of skeletal muscle contraction
relationship: part_of GO:0014852 ! regulation of skeletal muscle contraction by neural stimulation via neuromuscular junction

[Term]
id: GO:0014861
name: regulation of skeletal muscle contraction via regulation of action potential
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by depolarization of muscle membrane and ionic fluxes." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:mtg_muscle]
synonym: "regulation of skeletal muscle contraction via membrane action potential" RELATED []
is_a: GO:0014819 ! regulation of skeletal muscle contraction
is_a: GO:0098900 ! regulation of action potential
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: regulates GO:0100001 ! regulation of skeletal muscle contraction by action potential
relationship: regulates GO:0100001 ! regulation of skeletal muscle contraction by action potential

[Term]
id: GO:0014862
name: regulation of skeletal muscle contraction by chemo-mechanical energy conversion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by regulating force and velocity of shortening. The force of skeletal muscle contraction is produced by acto-myosin interaction processes through formation of cross bridges. The shortening leads to reduction of length of muscle fiber and sarcomeres." [GOC:mtg_muscle]
is_a: GO:0014819 ! regulation of skeletal muscle contraction

[Term]
id: GO:0014863
name: detection of inactivity
namespace: biological_process
def: "The series of events in which a inactivity stimulus is received by a cell or organism and converted into a molecular signal." [GOC:mtg_muscle]
is_a: GO:0014854 ! response to inactivity
is_a: GO:0051606 ! detection of stimulus

[Term]
id: GO:0014864
name: detection of muscle activity
namespace: biological_process
def: "The series of events in which a muscle activity stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_muscle]
is_a: GO:0014850 ! response to muscle activity
is_a: GO:0014865 ! detection of activity

[Term]
id: GO:0014865
name: detection of activity
namespace: biological_process
def: "The series of events in which an activity stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_muscle]
is_a: GO:0014823 ! response to activity
is_a: GO:0051606 ! detection of stimulus

[Term]
id: GO:0014866
name: skeletal myofibril assembly
namespace: biological_process
def: "The process whose specific outcome is the progression of the skeletal myofibril over time, from its formation to the mature structure. A skeletal myofibril is a myofibril specific to skeletal muscle cells." [GOC:ef, GOC:mtg_muscle]
is_a: GO:0030239 ! myofibril assembly

[Term]
id: GO:0014868
name: cross bridge cycling involved in regulation of the velocity of shortening in skeletal muscle contraction
namespace: biological_process
def: "A process in which cross bridges are broken and reformed during filament sliding as part of the regulation of the velocity of shortening in skeletal muscle contraction." [GOC:mtg_muscle]
is_a: GO:0014880 ! regulation of muscle filament sliding involved in regulation of the velocity of shortening in skeletal muscle contraction

[Term]
id: GO:0014869
name: detection of muscle inactivity
namespace: biological_process
def: "The series of events in which a muscle inactivity stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_muscle]
is_a: GO:0014863 ! detection of inactivity
is_a: GO:0014870 ! response to muscle inactivity

[Term]
id: GO:0014870
name: response to muscle inactivity
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle inactivity stimulus." [GOC:mtg_muscle]
is_a: GO:0014854 ! response to inactivity

[Term]
id: GO:0014871
name: cross bridge formation involved in regulation of the velocity of shortening in skeletal muscle contraction
namespace: biological_process
def: "The process in which actin and myosin interact, split ATP and generate force during skeletal muscle contraction. This process is one of the components of the regulation of the force of skeletal muscle contraction." [GOC:mtg_muscle]
is_a: GO:0014880 ! regulation of muscle filament sliding involved in regulation of the velocity of shortening in skeletal muscle contraction

[Term]
id: GO:0014872
name: myoblast division
namespace: biological_process
def: "The process resulting in the physical partitioning and separation of a myoblast into daughter cells. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle]
is_a: GO:0051301 ! cell division

[Term]
id: GO:0014873
name: response to muscle activity involved in regulation of muscle adaptation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus. This process occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle]
synonym: "response to fatigue" EXACT []
synonym: "response to muscle activity involved in regulation of muscle plasticity" RELATED []
is_a: GO:0014850 ! response to muscle activity
is_a: GO:0014874 ! response to stimulus involved in regulation of muscle adaptation
intersection_of: GO:0014850 ! response to muscle activity
intersection_of: part_of GO:0043502 ! regulation of muscle adaptation
relationship: part_of GO:0043502 ! regulation of muscle adaptation

[Term]
id: GO:0014874
name: response to stimulus involved in regulation of muscle adaptation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. This occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle]
synonym: "response to stimulus involved in regulation of muscle plasticity" RELATED []
is_a: GO:0050896 ! response to stimulus
intersection_of: GO:0050896 ! response to stimulus
intersection_of: part_of GO:0043502 ! regulation of muscle adaptation
relationship: part_of GO:0043502 ! regulation of muscle adaptation

[Term]
id: GO:0014875
name: detection of muscle activity involved in regulation of muscle adaptation
namespace: biological_process
def: "The series of events by which a muscle activity stimulus is received and converted into a molecular signal. This occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle]
synonym: "detection of fatigue" EXACT []
is_a: GO:0014864 ! detection of muscle activity
is_a: GO:0014873 ! response to muscle activity involved in regulation of muscle adaptation
intersection_of: GO:0014864 ! detection of muscle activity
intersection_of: part_of GO:0043502 ! regulation of muscle adaptation
relationship: part_of GO:0043502 ! regulation of muscle adaptation

[Term]
id: GO:0014876
name: response to injury involved in regulation of muscle adaptation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a injury. This process occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle]
synonym: "response to injury involved in regulation of muscle plasticity" RELATED []
is_a: GO:0009611 ! response to wounding
is_a: GO:0014874 ! response to stimulus involved in regulation of muscle adaptation

[Term]
id: GO:0014877
name: response to muscle inactivity involved in regulation of muscle adaptation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle inactivity stimulus. This process occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle]
is_a: GO:0014870 ! response to muscle inactivity
is_a: GO:0014874 ! response to stimulus involved in regulation of muscle adaptation
intersection_of: GO:0014870 ! response to muscle inactivity
intersection_of: part_of GO:0043502 ! regulation of muscle adaptation
relationship: part_of GO:0043502 ! regulation of muscle adaptation

[Term]
id: GO:0014878
name: response to electrical stimulus involved in regulation of muscle adaptation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. This process occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle]
synonym: "response to electrical stimulus involved in regulation of muscle plasticity" RELATED []
is_a: GO:0014874 ! response to stimulus involved in regulation of muscle adaptation
is_a: GO:0051602 ! response to electrical stimulus
intersection_of: GO:0051602 ! response to electrical stimulus
intersection_of: part_of GO:0043502 ! regulation of muscle adaptation
relationship: part_of GO:0043502 ! regulation of muscle adaptation

[Term]
id: GO:0014879
name: detection of electrical stimulus involved in regulation of muscle adaptation
namespace: biological_process
def: "The series of events by which an electrical stimulus is received and converted into a molecular signal. This occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle]
is_a: GO:0014878 ! response to electrical stimulus involved in regulation of muscle adaptation
is_a: GO:0050981 ! detection of electrical stimulus
intersection_of: GO:0050981 ! detection of electrical stimulus
intersection_of: part_of GO:0043502 ! regulation of muscle adaptation
relationship: part_of GO:0043502 ! regulation of muscle adaptation

[Term]
id: GO:0014880
name: regulation of muscle filament sliding involved in regulation of the velocity of shortening in skeletal muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of muscle filament sliding, and consequently contributes to the regulation of the velocity of shortening of skeletal muscle contraction." [GOC:dph, GOC:mtg_muscle, GOC:tb]
is_a: GO:0032971 ! regulation of muscle filament sliding
relationship: part_of GO:0014729 ! regulation of the velocity of shortening of skeletal muscle modulating contraction

[Term]
id: GO:0014881
name: regulation of myofibril size
namespace: biological_process
def: "Any process that modulates the size of myofibrils. A myofibril is the contractile element of skeletal and cardiac muscle. It is a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism." [GOC:dph, GOC:ef, GOC:mtg_muscle, GOC:tb]
synonym: "change of myofibril size" EXACT []
is_a: GO:0014743 ! regulation of muscle hypertrophy
is_a: GO:0032535 ! regulation of cellular component size

[Term]
id: GO:0014882
name: regulation of myofibril number
namespace: biological_process
def: "Any process that modulates the number of myofibrils. A myofibril is the contractile element of skeletal and cardiac muscle. It is a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism." [GOC:dph, GOC:ef, GOC:mtg_muscle, GOC:tb]
synonym: "change of myofibril number" EXACT []
is_a: GO:0014738 ! regulation of muscle hyperplasia
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0014883
name: transition between fast and slow fiber
namespace: biological_process
def: "The process of conversion of fast-contracting muscle fibers to a slower character. This may involve slowing of contractile rate, slow myosin gene induction, increase in oxidative metabolic properties, altered electrophysiology and altered innervation. This process also regulates skeletal muscle adapatation." [GOC:ef, GOC:mtg_muscle]
synonym: "transition between fast and slow fibre" EXACT []
synonym: "transition fast-slow fiber" EXACT []
synonym: "transition fast-slow fibre" EXACT []
is_a: GO:0014733 ! regulation of skeletal muscle adaptation

[Term]
id: GO:0014884
name: detection of muscle inactivity involved in regulation of muscle adaptation
namespace: biological_process
def: "The series of events in which a muscle inactivity stimulus is received by a cell and converted into a molecular signal. This occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle]
is_a: GO:0014869 ! detection of muscle inactivity
is_a: GO:0014877 ! response to muscle inactivity involved in regulation of muscle adaptation
intersection_of: GO:0014869 ! detection of muscle inactivity
intersection_of: part_of GO:0043502 ! regulation of muscle adaptation
relationship: part_of GO:0043502 ! regulation of muscle adaptation

[Term]
id: GO:0014885
name: detection of injury involved in regulation of muscle adaptation
namespace: biological_process
def: "The series of events by which an injury stimulus is received and converted into a molecular signal. This occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle]
synonym: "detection of injury involved in regulation of muscle plasticity" RELATED []
is_a: GO:0014822 ! detection of wounding
is_a: GO:0014876 ! response to injury involved in regulation of muscle adaptation
intersection_of: GO:0014822 ! detection of wounding
intersection_of: part_of GO:0043502 ! regulation of muscle adaptation
relationship: part_of GO:0043502 ! regulation of muscle adaptation

[Term]
id: GO:0014886
name: transition between slow and fast fiber
namespace: biological_process
def: "The process of conversion of slow-contracting muscle fibers to a faster character. This may involve increasing of contractile rate, fast myosin gene induction, increase in glycolytic metabolic properties, altered electrophysiology and altered innervation. This process also regulates skeletal muscle adapatation." [GOC:ef, GOC:mtg_muscle]
synonym: "transition between slow and fast fibre" EXACT []
synonym: "transition slow-fast fiber" EXACT []
synonym: "transition slow-fast fibre" EXACT []
is_a: GO:0014733 ! regulation of skeletal muscle adaptation

[Term]
id: GO:0014887
name: cardiac muscle adaptation
namespace: biological_process
def: "The process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:mtg_muscle]
synonym: "cardiac muscle plasticity" RELATED []
is_a: GO:0014888 ! striated muscle adaptation

[Term]
id: GO:0014888
name: striated muscle adaptation
namespace: biological_process
def: "Any process in which striated muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle]
synonym: "striated muscle plasticity" RELATED []
is_a: GO:0043500 ! muscle adaptation

[Term]
id: GO:0014889
name: muscle atrophy
namespace: biological_process
def: "A process, occurring in the muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse." [GOC:mtg_muscle]
comment: GO:0014889 should only be used for annotation when muscle atrophy is a normal physiological process and not a disease process.
xref: Wikipedia:Muscle_atrophy
is_a: GO:0043500 ! muscle adaptation

[Term]
id: GO:0014890
name: smooth muscle atrophy
namespace: biological_process
def: "A process, occurring in smooth muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse." [GOC:mtg_muscle]
is_a: GO:0014805 ! smooth muscle adaptation
is_a: GO:0014889 ! muscle atrophy

[Term]
id: GO:0014891
name: striated muscle atrophy
namespace: biological_process
def: "A process, occurring in striated muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse." [GOC:mtg_muscle]
is_a: GO:0014888 ! striated muscle adaptation
is_a: GO:0014889 ! muscle atrophy

[Term]
id: GO:0014893
name: response to rest involved in regulation of muscle adaptation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rest stimulus. This process occurs as part of the regulation of muscle adaptation." [GOC:mtg_muscle]
is_a: GO:0014877 ! response to muscle inactivity involved in regulation of muscle adaptation

[Term]
id: GO:0014894
name: response to denervation involved in regulation of muscle adaptation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a denervation stimulus. This process occurs as part of the regulation of muscle adaptation." [GOC:mtg_muscle]
is_a: GO:0014877 ! response to muscle inactivity involved in regulation of muscle adaptation

[Term]
id: GO:0014895
name: smooth muscle hypertrophy
namespace: biological_process
def: "The enlargement or overgrowth of all or part of an organ due to an increase in size of its smooth muscle cells without cell division. Physiological hypertrophy is a normal process during development, and can also occur in mature structures on demand. In the uterus, smooth muscle cells undergo hypertrophy during pregnancy." [GOC:mtg_muscle]
is_a: GO:0014805 ! smooth muscle adaptation
is_a: GO:0014896 ! muscle hypertrophy

[Term]
id: GO:0014896
name: muscle hypertrophy
namespace: biological_process
def: "The muscle system process that results in enlargement or overgrowth of all or part of a muscle organ due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development (it stops in cardiac muscle after adolescence) and can also be brought on in response to demand. In athletes cardiac and skeletal muscles undergo hypertrophy stimulated by increasing muscle activity on exercise. Smooth muscle cells in the uterus undergo hypertrophy during pregnancy." [GOC:mtg_muscle]
xref: Wikipedia:Muscle_hypertrophy
is_a: GO:0003012 ! muscle system process

[Term]
id: GO:0014897
name: striated muscle hypertrophy
namespace: biological_process
def: "The enlargement or overgrowth of all or part of an organ due to an increase in size of muscle cells without cell division. In the case of striated muscle, this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils." [GOC:mtg_muscle]
is_a: GO:0014896 ! muscle hypertrophy

[Term]
id: GO:0014898
name: cardiac muscle hypertrophy in response to stress
namespace: biological_process
def: "The physiological enlargement or overgrowth of all or part of the heart muscle due to an increase in size (not length) of individual cardiac muscle fibers, without cell division, as a result of a disturbance in organismal or cellular homeostasis." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:mtg_muscle]
is_a: GO:0003299 ! muscle hypertrophy in response to stress
is_a: GO:0003300 ! cardiac muscle hypertrophy
is_a: GO:0014887 ! cardiac muscle adaptation

[Term]
id: GO:0014899
name: cardiac muscle atrophy
namespace: biological_process
def: "A process, occurring in the heart, in which a decrease in cell mass and then in heart size occurs due to shrinking of the individual cells. The shrinkage is caused by protein degradation." [GOC:mtg_muscle]
is_a: GO:0014887 ! cardiac muscle adaptation
is_a: GO:0014891 ! striated muscle atrophy

[Term]
id: GO:0014900
name: muscle hyperplasia
namespace: biological_process
def: "A muscle system process that results in an increase in cell number by cell division, often leading to an increase in the size of an organ." [GOC:mtg_muscle]
is_a: GO:0043500 ! muscle adaptation

[Term]
id: GO:0014901
name: satellite cell activation involved in skeletal muscle regeneration
namespace: biological_process
def: "The process that initiates skeletal muscle satellite cell division by causing it to move from quiescence to the G1 stage of the cell cycle. The cell swells and there are a number of other small changes. The cells then start to divide. Following cell division the cells will differentiate. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage." [GOC:mtg_muscle]
is_a: GO:0014719 ! skeletal muscle satellite cell activation
intersection_of: GO:0014719 ! skeletal muscle satellite cell activation
intersection_of: part_of GO:0043403 ! skeletal muscle tissue regeneration
relationship: part_of GO:0043403 ! skeletal muscle tissue regeneration

[Term]
id: GO:0014902
name: myotube differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:mtg_muscle]
is_a: GO:0051146 ! striated muscle cell differentiation

[Term]
id: GO:0014904
name: myotube cell development
namespace: biological_process
def: "The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:mtg_muscle]
is_a: GO:0055002 ! striated muscle cell development
relationship: part_of GO:0014902 ! myotube differentiation

[Term]
id: GO:0014905
name: myoblast fusion involved in skeletal muscle regeneration
namespace: biological_process
def: "A process in which non-proliferating myoblasts, after migrating to the site of injury, fuse into existing damaged fibers or fuse to myotubes to form new fibers, as part of the process of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle]
is_a: GO:0007520 ! myoblast fusion
intersection_of: GO:0007520 ! myoblast fusion
intersection_of: part_of GO:0043403 ! skeletal muscle tissue regeneration
relationship: part_of GO:0014908 ! myotube differentiation involved in skeletal muscle regeneration
relationship: part_of GO:0043403 ! skeletal muscle tissue regeneration

[Term]
id: GO:0014906
name: myotube cell development involved in skeletal muscle regeneration
namespace: biological_process
def: "The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. This occurs as part of the process of skeletal muscle regeneration. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:mtg_muscle]
is_a: GO:0014904 ! myotube cell development
intersection_of: GO:0014904 ! myotube cell development
intersection_of: part_of GO:0043403 ! skeletal muscle tissue regeneration
relationship: part_of GO:0014908 ! myotube differentiation involved in skeletal muscle regeneration
relationship: part_of GO:0043403 ! skeletal muscle tissue regeneration

[Term]
id: GO:0014908
name: myotube differentiation involved in skeletal muscle regeneration
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. This process occurs as part of the process of skeletal muscle regeneration. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:mtg_muscle]
is_a: GO:0014902 ! myotube differentiation
intersection_of: GO:0014902 ! myotube differentiation
intersection_of: part_of GO:0043403 ! skeletal muscle tissue regeneration
relationship: part_of GO:0043403 ! skeletal muscle tissue regeneration

[Term]
id: GO:0014909
name: smooth muscle cell migration
namespace: biological_process
def: "The orderly movement of a smooth muscle cell from one site to another, often during the development of a multicellular organism." [CL:0000192, GOC:mtg_muscle]
is_a: GO:0014812 ! muscle cell migration

[Term]
id: GO:0014910
name: regulation of smooth muscle cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of smooth muscle cell migration." [CL:0000192, GOC:mtg_muscle]
is_a: GO:0030334 ! regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0014909 ! smooth muscle cell migration
relationship: regulates GO:0014909 ! smooth muscle cell migration

[Term]
id: GO:0014911
name: positive regulation of smooth muscle cell migration
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration." [CL:0000192, GOC:mtg_muscle]
is_a: GO:0014910 ! regulation of smooth muscle cell migration
is_a: GO:0030335 ! positive regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0014909 ! smooth muscle cell migration
relationship: positively_regulates GO:0014909 ! smooth muscle cell migration

[Term]
id: GO:0014912
name: negative regulation of smooth muscle cell migration
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell migration." [CL:0000192, GOC:mtg_muscle]
is_a: GO:0014910 ! regulation of smooth muscle cell migration
is_a: GO:0030336 ! negative regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0014909 ! smooth muscle cell migration
relationship: negatively_regulates GO:0014909 ! smooth muscle cell migration

[Term]
id: GO:0014914
name: myoblast maturation involved in muscle regeneration
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a myoblast cell to attain its fully functional state involved in muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle]
is_a: GO:0048628 ! myoblast maturation

[Term]
id: GO:0014915
name: regulation of muscle filament sliding speed involved in regulation of the velocity of shortening in skeletal muscle contraction
namespace: biological_process
def: "Any process that modulates the velocity of muscle filament sliding, and consequently contributes to the regulation of the velocity of shortening of skeletal muscle contraction." [GOC:dph, GOC:mtg_muscle, GOC:tb]
is_a: GO:0014880 ! regulation of muscle filament sliding involved in regulation of the velocity of shortening in skeletal muscle contraction
is_a: GO:0032972 ! regulation of muscle filament sliding speed

[Term]
id: GO:0014916
name: regulation of lung blood pressure
namespace: biological_process
def: "The process that modulates the force with which blood travels through the lungs. The process is controlled by a balance of processes that increase pressure and decrease pressure." [GOC:mtg_cardio]
synonym: "regulation of pulmonary blood pressure" EXACT []
is_a: GO:0008217 ! regulation of blood pressure

[Term]
id: GO:0014917
name: obsolete positive regulation of diuresis by pressure natriuresis
namespace: biological_process
def: "OBSOLETE. The process in which pressure natriuresis increases the rate of diuresis." [GOC:mtg_cardio]
comment: This term was made obsolete because its definition was inaccurate.
synonym: "positive regulation of diuresis by pressure natriuresis" EXACT []
is_obsolete: true
replaced_by: GO:0035818

[Term]
id: GO:0014918
name: obsolete positive regulation of natriuresis by pressure natriuresis
namespace: biological_process
def: "OBSOLETE. The process in which pressure natriuresis increases rate of natriuresis." [GOC:mtg_cardio]
comment: This term was made obsolete because its definition was inaccurate.
synonym: "positive regulation of natriuresis by pressure natriuresis" EXACT []
is_obsolete: true
replaced_by: GO:0035819

[Term]
id: GO:0015000
name: obsolete polyferredoxin
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it does not represent a function.
synonym: "polyferredoxin" EXACT []
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0015001
name: obsolete high-potential iron-sulfur carrier
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it refers to a class of gene products.
synonym: "high-potential iron-sulfur carrier" EXACT []
synonym: "high-potential iron-sulphur carrier" EXACT []
synonym: "HiPIP" RELATED []
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0015002
name: heme-copper terminal oxidase activity
namespace: molecular_function
def: "Catalysis of the four-electron reduction of dioxygen (O2) to water, coupled to generation of a proton electrochemical gradient across a membrane." [GOC:kd]
subset: gosubset_prok
synonym: "haem-copper terminal oxidase activity" EXACT []
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0015003
name: obsolete copper electron carrier
namespace: molecular_function
def: "OBSOLETE. A copper-containing entity that serves as an electron acceptor and electron donor in an electron transport system." [GOC:ai]
comment: This term was made obsolete because it refers to a class of gene products.
synonym: "copper electron carrier" EXACT []
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0015004
name: obsolete small blue copper electron carrier
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it does not represent a molecular function.
synonym: "small blue copper electron carrier" EXACT []
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0015005
name: obsolete azurin
namespace: molecular_function
def: "OBSOLETE. Brilliant blue copper-containing protein of low molecular weight found in some bacteria; thought to transfer electrons to cytochrome oxidase. This definition includes pseudoazurin." [ISBN:0198547684]
comment: This term was made obsolete because it does not represent a molecular function.
synonym: "azurin" EXACT []
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0015006
name: obsolete plastocyanin
namespace: molecular_function
def: "OBSOLETE. A copper-containing electron carrier acting between cytochrome b(6)-f and P700 of photosystem I." [ISBN:0198547684]
comment: This term was made obsolete because it does not represent a molecular function.
synonym: "plastocyanin" EXACT []
is_obsolete: true
replaced_by: GO:0046028

[Term]
id: GO:0015007
name: obsolete electron carrier, chlorophyll electron transport system
namespace: molecular_function
def: "OBSOLETE. A molecular entity that serves as an electron acceptor and electron donor in a chlorophyll electron transport system." [ISBN:0198506732]
comment: This term was made obsolete because it contains both process and function information.
synonym: "chlorophyll electron carrier" RELATED []
synonym: "electron carrier, chlorophyll electron transport system" EXACT []
is_obsolete: true
consider: GO:0009055
consider: GO:0009767

[Term]
id: GO:0015009
name: corrin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving corrin, C19H22N4, the fundamental heterocyclic skeleton of the corrinoids. It consists of four reduced pyrrole rings joined into a macrocyclic ring. Corrin is the core of the vitamin B12 molecule." [GOC:ai, ISBN:0198506732]
subset: gosubset_prok
synonym: "corrin metabolism" EXACT []
is_a: GO:0033013 ! tetrapyrrole metabolic process
is_a: GO:0051186 ! cofactor metabolic process

[Term]
id: GO:0015010
name: tetrahydrocorphin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tetrahydrocorphins, tetrapyrroles that combine the structural elements of both porphyrins and corrins." [http://findarticles.com/p/articles/mi_m0841/is_n1_v28/ai_13746418, http://www.chem.qmul.ac.uk/iupac/bioinorg/CD.html#44]
subset: gosubset_prok
synonym: "tetrahydrocorphin metabolism" EXACT []
is_a: GO:0015011 ! nickel-tetrapyrrole coenzyme metabolic process

[Term]
id: GO:0015011
name: nickel-tetrapyrrole coenzyme metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an enzyme cofactor consisting of a tetrapyrrole structure containing nickel, such as the F-430 cofactor found in methyl-coenzyme M reductase." [GOC:mah, http://www.chem.qmul.ac.uk/iupac/bioinorg/CD.html#44, http://www.chem.qmul.ac.uk/iupac/bioinorg/EG.html#33]
subset: gosubset_prok
synonym: "coenzyme F430 metabolic process" NARROW []
synonym: "nickel-tetrapyrrole coenzyme metabolism" EXACT []
is_a: GO:0006732 ! coenzyme metabolic process
is_a: GO:0033013 ! tetrapyrrole metabolic process

[Term]
id: GO:0015012
name: heparan sulfate proteoglycan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues." [GOC:mah, ISBN:0198506732, ISBN:0198547684, RESID:AA0210]
subset: gosubset_prok
synonym: "heparan sulfate proteoglycan anabolism" EXACT []
synonym: "heparan sulfate proteoglycan biosynthesis" EXACT []
synonym: "heparan sulfate proteoglycan formation" EXACT []
synonym: "heparan sulfate proteoglycan synthesis" EXACT []
synonym: "heparan sulphate proteoglycan biosynthesis" EXACT []
synonym: "heparan sulphate proteoglycan biosynthetic process" EXACT []
synonym: "heparin proteoglycan biosynthetic process" RELATED []
xref: RESID:AA0210
is_a: GO:0030166 ! proteoglycan biosynthetic process
is_a: GO:0030201 ! heparan sulfate proteoglycan metabolic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:0044711 ! single-organism biosynthetic process

[Term]
id: GO:0015013
name: heparan sulfate proteoglycan biosynthetic process, linkage to polypeptide
namespace: biological_process
def: "The polymerization of one or more heparan sulfate chains via a xylose link onto serine residues in the core protein of a proteoglycan." [ISBN:0815316194]
subset: gosubset_prok
synonym: "heparan sulfate proteoglycan anabolism, linkage to polypeptide" EXACT []
synonym: "heparan sulfate proteoglycan formation, linkage to polypeptide" EXACT []
synonym: "heparan sulfate proteoglycan synthesis, linkage to polypeptide" EXACT []
synonym: "heparan sulphate proteoglycan biosynthesis, linkage to polypeptide" EXACT []
synonym: "heparan sulphate proteoglycan biosynthetic process, linkage to polypeptide" EXACT []
synonym: "heparin proteoglycan biosynthetic process, linkage to polypeptide" RELATED []
is_a: GO:0018242 ! protein O-linked glycosylation via serine
is_a: GO:0030201 ! heparan sulfate proteoglycan metabolic process
relationship: part_of GO:0015012 ! heparan sulfate proteoglycan biosynthetic process

[Term]
id: GO:0015014
name: heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of polysaccharide chain component of heparan sulfate proteoglycan." [GOC:ai]
subset: gosubset_prok
synonym: "heparan sulfate proteoglycan anabolism, polysaccharide chain anabolism" EXACT []
synonym: "heparan sulfate proteoglycan chain elongation" EXACT []
synonym: "heparan sulfate proteoglycan formation, polysaccharide chain biosynthesis" EXACT []
synonym: "heparan sulfate proteoglycan formation, polysaccharide chain formation" EXACT []
synonym: "heparan sulfate proteoglycan synthesis, polysaccharide chain synthesis" EXACT []
synonym: "heparan sulphate proteoglycan biosynthesis, polysaccharide chain biosynthesis" EXACT []
synonym: "heparan sulphate proteoglycan biosynthesis, polysaccharide chain biosynthetic process" EXACT []
synonym: "heparin proteoglycan biosynthetic process, polysaccharide chain biosynthetic process" RELATED []
is_a: GO:0033692 ! cellular polysaccharide biosynthetic process
relationship: part_of GO:0015012 ! heparan sulfate proteoglycan biosynthetic process

[Term]
id: GO:0015015
name: heparan sulfate proteoglycan biosynthetic process, enzymatic modification
namespace: biological_process
def: "The modification, often by sulfation, of sugars incorporated into heparan sulfate after polymerization." [ISBN:0815316194]
subset: gosubset_prok
synonym: "heparan sulfate proteoglycan anabolism, enzymatic modification" EXACT []
synonym: "heparan sulfate proteoglycan formation, enzymatic modification" EXACT []
synonym: "heparan sulfate proteoglycan synthesis, enzymatic modification" EXACT []
synonym: "heparan sulphate proteoglycan biosynthesis, enzymatic modification" EXACT []
synonym: "heparan sulphate proteoglycan biosynthetic process, enzymatic modification" EXACT []
synonym: "heparin proteoglycan biosynthetic process, enzymatic modification" RELATED []
is_a: GO:0030201 ! heparan sulfate proteoglycan metabolic process
relationship: part_of GO:0015012 ! heparan sulfate proteoglycan biosynthetic process

[Term]
id: GO:0015016
name: [heparan sulfate]-glucosamine N-sulfotransferase activity
namespace: molecular_function
alt_id: GO:0004393
alt_id: GO:0015022
alt_id: GO:0051910
def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine." [EC:2.8.2.8]
comment: Note that this activity includes EC:2.8.2.12 (deleted from EC).
synonym: "3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine N-sulfotransferase activity" EXACT [EC:2.8.2.8]
synonym: "3'-phosphoadenylyl-sulfate:heparitin N-sulfotransferase activity" EXACT [EC:2.8.2.8]
synonym: "3'-phosphoadenylyl-sulfate:N-desulfoheparin N-sulfotransferase activity" EXACT [EC:2.8.2.8]
synonym: "3'-phosphoadenylylsulfate:N-desulfoheparin sulfotransferase activity" EXACT [EC:2.8.2.8]
synonym: "[heparan sulphate]-glucosamine N-sulphotransferase activity" EXACT []
synonym: "desulfoheparin sulfotransferase activity" EXACT []
synonym: "glucosaminyl N-deacetylase/N-sulfotransferase activity" EXACT [EC:2.8.2.8]
synonym: "heparan sulfate 2-N-sulfotransferase activity" EXACT [EC:2.8.2.8]
synonym: "heparan sulfate N-deacetylase/N-sulfotransferase activity" EXACT [EC:2.8.2.8]
synonym: "heparan sulfate N-sulfotransferase activity" EXACT [EC:2.8.2.8]
synonym: "heparin N-deacetylase/N-sulfotransferase activity" RELATED []
synonym: "heparin N-deacetylase/N-sulphotransferase activity" RELATED []
synonym: "heparin N-sulfotransferase activity" EXACT [EC:2.8.2.8]
synonym: "heparin-glucosamine N-sulfotransferase activity" EXACT []
synonym: "heparitin N-sulfotransferase activity" EXACT []
synonym: "heparitin N-sulphotransferase activity" EXACT []
synonym: "heparitin sulfotransferase activity" EXACT []
synonym: "N-desulfoheparin sulfotransferase activity" EXACT [EC:2.8.2.8]
synonym: "N-heparan sulfate sulfotransferase activity" EXACT [EC:2.8.2.8]
synonym: "N-HSST activity" EXACT [EC:2.8.2.8]
synonym: "PAPS:DSH sulfotransferase activity" EXACT [EC:2.8.2.8]
synonym: "PAPS:N-desulfoheparin sulfotransferase activity" EXACT [EC:2.8.2.8]
xref: EC:2.8.2.8
xref: MetaCyc:HEPARITIN-SULFOTRANSFERASE-RXN
is_a: GO:0034483 ! heparan sulfate sulfotransferase activity

[Term]
id: GO:0015017
name: obsolete glypican
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product (was misspelled 'glycipan').
synonym: "glypican" EXACT []
is_obsolete: true

[Term]
id: GO:0015018
name: galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein." [EC:2.4.1.135]
synonym: "glucuronosyltransferase I activity" NARROW [EC:2.4.1.135]
synonym: "UDP-glucuronate:3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosyl-protein D-glucuronosyltransferase activity" EXACT [EC:2.4.1.135]
synonym: "UDPglucuronate:3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosyl-protein D-glucuronosyltransferase activity" EXACT [EC:2.4.1.135]
synonym: "uridine diphosphate glucuronic acid:acceptor glucuronosyltransferase activity" EXACT [EC:2.4.1.135]
xref: EC:2.4.1.135
xref: MetaCyc:2.4.1.135-RXN
is_a: GO:0015020 ! glucuronosyltransferase activity

[Term]
id: GO:0015019
name: heparan-alpha-glucosaminide N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + heparan alpha-D-glucosaminide = CoA + heparan N-acetyl-alpha-D-glucosaminide." [EC:2.3.1.78]
synonym: "acetyl-CoA:alpha-glucosaminide N-acetyltransferase activity" EXACT [EC:2.3.1.78]
synonym: "acetyl-CoA:heparan-alpha-D-glucosaminide N-acetyltransferase activity" EXACT [EC:2.3.1.78]
synonym: "heparin-alpha-glucosaminide N-acetyltransferase activity" RELATED []
xref: EC:2.3.1.78
xref: MetaCyc:2.3.1.78-RXN
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0015020
name: glucuronosyltransferase activity
namespace: molecular_function
alt_id: GO:0003981
def: "Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside." [EC:2.4.1.17]
synonym: "1-naphthol glucuronyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "1-naphthol-UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "17-beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "17-OH steroid UDPGT activity" NARROW [EC:2.4.1.17]
synonym: "17beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "3-OH androgenic UDPGT activity" NARROW [EC:2.4.1.17]
synonym: "3alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "4-hydroxybiphenyl UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "4-methylumbelliferone UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "4-nitrophenol UDP-glucuronyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "4-nitrophenol UDPGT activity" NARROW [EC:2.4.1.17]
synonym: "bilirubin glucuronyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "bilirubin monoglucuronide glucuronyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "bilirubin UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "bilirubin UDPGT activity" NARROW [EC:2.4.1.17]
synonym: "bilirubin uridine diphosphoglucuronyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "ciramadol UDP-glucuronyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "estriol UDPglucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "estrone UDPglucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "GT activity" EXACT [EC:2.4.1.17]
synonym: "morphine glucuronyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "p-hydroxybiphenyl UDP glucuronyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "p-nitrophenol UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "p-nitrophenol UDP-glucuronyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "p-nitrophenylglucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "p-phenylphenol glucuronyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "phenyl-UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "PNP-UDPGT" RELATED [EC:2.4.1.17]
synonym: "pnp-UDPGT activity" NARROW [EC:2.4.1.17]
synonym: "UDP glucuronate-estradiol-glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "UDP glucuronate-estriol glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "UDP glucuronic acid transferase activity" EXACT [EC:2.4.1.17]
synonym: "UDP glucuronosyltransferase activity" EXACT [EC:2.4.1.17]
synonym: "UDP glucuronyltransferase activity" EXACT [EC:2.4.1.17]
synonym: "UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)" EXACT [EC:2.4.1.17]
synonym: "UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "UDP-glucuronate-bilirubin glucuronyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "UDP-glucuronosyltransferase activity" EXACT [EC:2.4.1.17]
synonym: "UDP-glucuronyltransferase activity" EXACT [EC:2.4.1.17]
synonym: "UDPGA transferase activity" EXACT [EC:2.4.1.17]
synonym: "UDPGA-glucuronyltransferase activity" EXACT [EC:2.4.1.17]
synonym: "UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity" NARROW [EC:2.4.1.17]
synonym: "UDPGT activity" EXACT [EC:2.4.1.17]
synonym: "uridine 5'-diphosphoglucuronyltransferase activity" EXACT [EC:2.4.1.17]
synonym: "uridine diphosphate glucuronyltransferase activity" EXACT [EC:2.4.1.17]
synonym: "uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "uridine diphosphoglucuronate-estriol glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "uridine diphosphoglucuronosyltransferase activity" EXACT [EC:2.4.1.17]
synonym: "uridine diphosphoglucuronyltransferase activity" EXACT [EC:2.4.1.17]
xref: EC:2.4.1.17
xref: MetaCyc:UDP-GLUCURONOSYLTRANSFERASE-RXN
xref: Reactome:REACT_100484 "bilirubin monoglucuronide + UDP-glucuronic acid => bilirubin diglucuronide + UDP, Mus musculus"
xref: Reactome:REACT_100951 "bilirubin + UDP-glucuronic acid => bilirubin monoglucuronide + UDP, Bos taurus"
xref: Reactome:REACT_102236 "Formation of N-glucuronides, Sus scrofa"
xref: Reactome:REACT_108741 "Formation of O-glucuronides, Taeniopygia guttata"
xref: Reactome:REACT_108947 "Formation of N-glucuronides, Mus musculus"
xref: Reactome:REACT_109353 "bilirubin + UDP-glucuronic acid => bilirubin monoglucuronide + UDP, Taeniopygia guttata"
xref: Reactome:REACT_109881 "Formation of N-glucuronides, Canis familiaris"
xref: Reactome:REACT_109887 "bilirubin monoglucuronide + UDP-glucuronic acid => bilirubin diglucuronide + UDP, Bos taurus"
xref: Reactome:REACT_112395 "Formation of O-glucuronides, Caenorhabditis elegans"
xref: Reactome:REACT_113946 "bilirubin + UDP-glucuronic acid => bilirubin monoglucuronide + UDP, Caenorhabditis elegans"
xref: Reactome:REACT_114051 "Formation of N-glucuronides, Caenorhabditis elegans"
xref: Reactome:REACT_114908 "bilirubin monoglucuronide + UDP-glucuronic acid => bilirubin diglucuronide + UDP, Caenorhabditis elegans"
xref: Reactome:REACT_22274 "bilirubin + UDP-glucuronic acid => bilirubin monoglucuronide + UDP, Homo sapiens"
xref: Reactome:REACT_22319 "bilirubin monoglucuronide + UDP-glucuronic acid => bilirubin diglucuronide + UDP, Homo sapiens"
xref: Reactome:REACT_33930 "Formation of O-glucuronides, Danio rerio"
xref: Reactome:REACT_6815 "Formation of O-glucuronides, Homo sapiens"
xref: Reactome:REACT_6956 "Formation of N-glucuronides, Homo sapiens"
xref: Reactome:REACT_79204 "bilirubin monoglucuronide + UDP-glucuronic acid => bilirubin diglucuronide + UDP, Rattus norvegicus"
xref: Reactome:REACT_80868 "bilirubin + UDP-glucuronic acid => bilirubin monoglucuronide + UDP, Mus musculus"
xref: Reactome:REACT_82682 "bilirubin + UDP-glucuronic acid => bilirubin monoglucuronide + UDP, Rattus norvegicus"
xref: Reactome:REACT_88594 "Formation of N-glucuronides, Danio rerio"
xref: Reactome:REACT_88769 "Formation of O-glucuronides, Mus musculus"
xref: Reactome:REACT_89037 "Formation of O-glucuronides, Bos taurus"
xref: Reactome:REACT_89779 "Formation of O-glucuronides, Sus scrofa"
xref: Reactome:REACT_90433 "bilirubin monoglucuronide + UDP-glucuronic acid => bilirubin diglucuronide + UDP, Taeniopygia guttata"
xref: Reactome:REACT_92344 "Formation of N-glucuronides, Taeniopygia guttata"
xref: Reactome:REACT_92859 "bilirubin monoglucuronide + UDP-glucuronic acid => bilirubin diglucuronide + UDP, Danio rerio"
xref: Reactome:REACT_96239 "bilirubin + UDP-glucuronic acid => bilirubin monoglucuronide + UDP, Sus scrofa"
xref: Reactome:REACT_96288 "bilirubin + UDP-glucuronic acid => bilirubin monoglucuronide + UDP, Danio rerio"
xref: Reactome:REACT_96318 "bilirubin monoglucuronide + UDP-glucuronic acid => bilirubin diglucuronide + UDP, Sus scrofa"
xref: Reactome:REACT_99268 "Formation of O-glucuronides, Rattus norvegicus"
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0015021
name: heparin-sulfate lyase activity
namespace: molecular_function
def: "Catalysis of the elimination of sulfate; appears to act on linkages between N-acetyl-D-glucosamine and uronate. Product is an unsaturated sugar." [EC:4.2.2.8]
subset: gosubset_prok
synonym: "[heparan sulfate]-sulfate lyase activity" RELATED []
synonym: "heparin-sulfate eliminase activity" RELATED [EC:4.2.2.8]
synonym: "heparin-sulphate lyase activity" EXACT []
synonym: "heparitin-sulfate lyase activity" EXACT []
synonym: "heparitinase I" RELATED [EC:4.2.2.8]
synonym: "heparitinase II" RELATED [EC:4.2.2.8]
xref: EC:4.2.2.8
xref: MetaCyc:4.2.2.8-RXN
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0015023
name: obsolete syndecan
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "syndecan" EXACT []
is_obsolete: true

[Term]
id: GO:0015024
name: glucuronate-2-sulfatase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate." [EC:3.1.6.18]
synonym: "chondro-2-sulfatase activity" EXACT [EC:3.1.6.18]
synonym: "glucuronate-2-sulphatase activity" EXACT []
synonym: "glucurono-2-sulfatase activity" EXACT [EC:3.1.6.18]
synonym: "polysaccharide-2-O-sulfo-D-glucuronate 2-sulfohydrolase activity" EXACT [EC:3.1.6.18]
xref: EC:3.1.6.18
xref: MetaCyc:3.1.6.18-RXN
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0015025
name: obsolete GPI-anchored membrane-bound receptor
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it contains both component and function information.
synonym: "GPI-anchored membrane-bound receptor" EXACT []
is_obsolete: true
replaced_by: GO:0031225
consider: GO:0004872

[Term]
id: GO:0015026
name: coreceptor activity
namespace: molecular_function
alt_id: GO:0015027
alt_id: GO:0015028
def: "Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity." [GOC:go_curators]
synonym: "coreceptor, insoluble ligand activity" RELATED [GOC:mah]
synonym: "coreceptor, soluble ligand activity" RELATED [GOC:mah]
is_a: GO:0038023 ! signaling receptor activity

[Term]
id: GO:0015029
name: obsolete internalization receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because internalization is a process, not a ligand to which a receptor might bind.
synonym: "internalization receptor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0015030
name: Cajal body
namespace: cellular_component
def: "A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA." [NIF_Subcellular:nlx_subcell_090901, PMID:10944589, PMID:11031238, PMID:7559785]
synonym: "coiled body" EXACT []
synonym: "Gemini of coiled bodies" RELATED []
synonym: "Gems" RELATED []
xref: NIF_Subcellular:nlx_subcell_090901
xref: Wikipedia:Cajal_body
is_a: GO:0016604 ! nuclear body

[Term]
id: GO:0015031
name: protein transport
namespace: biological_process
alt_id: GO:0015831
def: "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "enzyme transport" NARROW []
is_a: GO:0008104 ! protein localization
is_a: GO:0045184 ! establishment of protein localization
is_a: GO:0071702 ! organic substance transport

[Term]
id: GO:0015032
name: storage protein import into fat body
namespace: biological_process
def: "The incorporation of hemolymph proteins by cells of the fat body of holometabolous insects, during the final larval stage. Uptake of these proteins prepares the insect for pupation and metamorphosis, since insect pupae do not feed and therefore depend on material that has been accumulated during larval life." [GOC:bf, PMID:10231363]
synonym: "fat body metabolic process" BROAD []
synonym: "fat body metabolism" BROAD []
synonym: "fat body storage protein uptake" EXACT []
synonym: "import of storage protein into fat body" EXACT []
synonym: "storage protein import by fat body cells" EXACT []
synonym: "storage protein import into fat body cells" EXACT []
synonym: "storage protein transport into fat body cells" EXACT []
synonym: "storage protein uptake into fat body cells" EXACT []
is_a: GO:0044743 ! intracellular protein transmembrane import

[Term]
id: GO:0015034
name: obsolete cytochrome P450 activity
namespace: molecular_function
def: "OBSOLETE. A cytochrome b-like protein that has a sulfur atom ligated to the iron of the prosthetic group (heme-thiolate); enzymes: typically monooxygenases acting on, typically, lipophilic substrates. The characteristic mode of action of these enzymes is not electron transfer (some P450 enzymes probably do not even involve the reversible Fe(II)/Fe(III) equilibrium), but rather oxygen atom transfer." [ISBN:0198547684, PMID:1655423]
comment: This term was made obsolete because it is a grouping term representing a set of gene products.
synonym: "cytochrome P450 activity" EXACT []
is_obsolete: true
consider: GO:0019825

[Term]
id: GO:0015035
name: protein disulfide oxidoreductase activity
namespace: molecular_function
alt_id: GO:0008895
def: "Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [MetaCyc:DISULFOXRED-RXN]
subset: gosubset_prok
synonym: "haem lyase disulphide oxidoreductase activity" NARROW []
synonym: "heme lyase disulfide oxidoreductase activity" NARROW []
synonym: "protein disulphide oxidoreductase activity" EXACT []
synonym: "thioredoxin activity" NARROW [GOC:mah, GOC:vw]
xref: MetaCyc:DISULFOXRED-RXN
is_a: GO:0015036 ! disulfide oxidoreductase activity

[Term]
id: GO:0015036
name: disulfide oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds." [MetaCyc:DISULFOXRED-RXN]
subset: gosubset_prok
synonym: "disulphide oxidoreductase activity" EXACT []
xref: Reactome:REACT_103411 "Oxidation of Cysteine to Cystine in Proinsulin, Canis familiaris"
xref: Reactome:REACT_106321 "Oxidation of Cysteine to Cystine in Proinsulin, Gallus gallus"
xref: Reactome:REACT_107245 "Oxidation of Cysteine to Cystine in Proinsulin, Rattus norvegicus"
xref: Reactome:REACT_107998 "Oxidation of Cysteine to Cystine in Proinsulin, Mus musculus"
xref: Reactome:REACT_108531 "Oxidation of Cysteine to Cystine in Proinsulin, Danio rerio"
xref: Reactome:REACT_15454 "Oxidation of Cysteine to Cystine in Proinsulin, Homo sapiens"
xref: Reactome:REACT_77430 "Oxidation of Cysteine to Cystine in Proinsulin, Bos taurus"
xref: Reactome:REACT_77708 "Oxidation of Cysteine to Cystine in Proinsulin, Xenopus tropicalis"
xref: Reactome:REACT_96324 "Oxidation of Cysteine to Cystine in Proinsulin, Taeniopygia guttata"
is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors

[Term]
id: GO:0015037
name: peptide disulfide oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: a peptide with reduced sulfide groups = a peptide with oxidized disulfide bonds." [GOC:mah, MetaCyc:DISULFOXRED-RXN]
subset: gosubset_prok
synonym: "peptide disulphide oxidoreductase activity" EXACT []
is_a: GO:0015036 ! disulfide oxidoreductase activity

[Term]
id: GO:0015038
name: glutathione disulfide oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 glutathione + electron acceptor = glutathione disulfide + electron donor." [GOC:mah]
subset: gosubset_prok
synonym: "glutaredoxin" RELATED []
synonym: "glutathione disulphide oxidoreductase activity" EXACT []
xref: Reactome:REACT_104955 "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized), Mus musculus"
xref: Reactome:REACT_108454 "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized), Xenopus tropicalis"
xref: Reactome:REACT_112460 "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized), Arabidopsis thaliana"
xref: Reactome:REACT_114108 "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized), Oryza sativa"
xref: Reactome:REACT_114787 "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized), Plasmodium falciparum"
xref: Reactome:REACT_1461 "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized), Homo sapiens"
xref: Reactome:REACT_31672 "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized), Caenorhabditis elegans"
xref: Reactome:REACT_32436 "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized), Danio rerio"
xref: Reactome:REACT_34589 "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized), Canis familiaris"
xref: Reactome:REACT_77557 "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized), Rattus norvegicus"
xref: Reactome:REACT_84272 "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized), Gallus gallus"
xref: Reactome:REACT_89388 "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized), Sus scrofa"
xref: Reactome:REACT_94243 "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized), Bos taurus"
is_a: GO:0015037 ! peptide disulfide oxidoreductase activity

[Term]
id: GO:0015039
name: NADPH-adrenodoxin reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: oxidized adrenodoxin + NADPH + H+ = reduced adrenodoxin + NADP+." [EC:1.18.1.6, GOC:kd]
comment: Note that this term specifically refers to the reaction proceeding in the direction shown; under physiological conditions adrenodoxin reduction by adrenodoxin reductase is coupled with electron transfer from AdR to P450, which catalyzes an irreversible monooxygenation reaction. This term should therefore be used to annotate gene products that catalyze the reduction of oxidized adrenodoxin; also consider annotating to the molecular function term 'ferredoxin-NADP+ reductase activity ; GO:0004324'.
synonym: "adrenodoxin reductase activity" BROAD [EC:1.18.1.2]
synonym: "adrenodoxin-type ferredoxin reductase activity" EXACT [GOC:kd]
synonym: "NADPH:adrenodoxin oxidoreductase activity" EXACT [EC:1.18.1.2]
xref: EC:1.18.1.-
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0015040
name: obsolete electron transfer flavoprotein, group I
namespace: molecular_function
def: "OBSOLETE. An electron transfer flavoprotein that functions as a housekeeping protein that links acyl-CoA dehydrogenase reactions with the respiratory chain, such as in the fatty acid degradation pathway." [PMID:8599534]
comment: This term was made obsolete because it refers to a class of gene products.
synonym: "electron transfer flavoprotein, group I" EXACT []
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0015041
name: obsolete electron transfer flavoprotein, group II
namespace: molecular_function
def: "OBSOLETE. An electron transfer flavoprotein that functions as a housekeeping protein that is synthesized only under certain specific growth conditions and receives electrons from the oxidation of specific substrates, e.g. trimethylamine, carnitine and in nitrogen fixation." [PMID:8599534]
comment: This term was made obsolete because it refers to a class of gene products.
synonym: "electron transfer flavoprotein, group II" EXACT []
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0015042
name: trypanothione-disulfide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + trypanothione = NADPH + H+ + trypanothione disulfide." [EC:1.8.1.12]
comment: Note that this function was formerly EC:1.6.4.8.
synonym: "N(1),N(8)-bis(glutathionyl)spermidine reductase activity" EXACT [EC:1.8.1.12]
synonym: "N1,N8-bis(glutathionyl)spermidine reductase activity" EXACT [EC:1.8.1.12]
synonym: "NADPH2:trypanothione oxidoreductase activity" EXACT [EC:1.8.1.12]
synonym: "NADPH:trypanothione oxidoreductase activity" EXACT [EC:1.8.1.12]
synonym: "trypanothione reductase activity" EXACT []
synonym: "trypanothione-disulphide reductase activity" EXACT []
synonym: "trypanothione:NADP+ oxidoreductase activity" EXACT [EC:1.8.1.12]
xref: EC:1.8.1.12
xref: MetaCyc:1.8.1.12-RXN
xref: RHEA:16760
is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor

[Term]
id: GO:0015043
name: leghemoglobin reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADPH + H+ + 2 ferrileghemoglobin = NADP+ + 2 ferroleghemoglobin." [EC:1.6.2.6]
synonym: "ferric leghemoglobin reductase activity" EXACT [EC:1.6.2.6]
synonym: "NAD(P)H:ferrileghemoglobin oxidoreductase activity" EXACT [EC:1.6.2.6]
xref: EC:1.6.2.6
xref: MetaCyc:LEGHEMOGLOBIN-REDUCTASE-RXN
is_a: GO:0016653 ! oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor

[Term]
id: GO:0015044
name: rubredoxin-NAD+ reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: reduced rubredoxin + NAD+ = oxidized rubredoxin + NADH + H+." [EC:1.18.1.1]
subset: gosubset_prok
synonym: "dihydronicotinamide adenine dinucleotide--rubredoxin reductase activity" EXACT [EC:1.18.1.1]
synonym: "DPNH-rubredoxin reductase activity" EXACT [EC:1.18.1.1]
synonym: "NADH--rubredoxin oxidoreductase activity" EXACT [EC:1.18.1.1]
synonym: "NADH--rubredoxin reductase activity" EXACT [EC:1.18.1.1]
synonym: "NADH:rubredoxin oxidoreductase activity" EXACT [EC:1.18.1.1]
synonym: "NADH:rubredoxin reductase activity" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide--rubredoxin reductase activity" EXACT [EC:1.18.1.1]
synonym: "rubredoxin--NAD reductase activity" EXACT [EC:1.18.1.1]
synonym: "rubredoxin--nicotinamide adenine dinucleotide reductase activity" EXACT [EC:1.18.1.1]
synonym: "rubredoxin:NAD+ oxidoreductase activity" EXACT [EC:1.18.1.1]
xref: EC:1.18.1.1
xref: MetaCyc:RUBREDOXIN--NAD+-REDUCTASE-RXN
is_a: GO:0016731 ! oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor

[Term]
id: GO:0015045
name: rubredoxin-NAD(P)+ reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: reduced rubredoxin + NAD(P)+ = oxidized rubredoxin + NAD(P)H + H+." [EC:1.18.1.4]
synonym: "dinucleotide phosphate reductase activity" RELATED [EC:1.18.1.4]
synonym: "NAD(P)--rubredoxin oxidoreductase activity" EXACT [EC:1.18.1.4]
synonym: "NAD(P)H--rubredoxin oxidoreductase activity" EXACT [EC:1.18.1.4]
synonym: "NADPH:rubredoxin reductase activity" EXACT []
synonym: "rubredoxin--nicotinamide adenine activity" RELATED [EC:1.18.1.4]
synonym: "rubredoxin--nicotinamide adenine dinucleotide (phosphate) reductase activity" EXACT [EC:1.18.1.4]
synonym: "rubredoxin:NAD(P)+ oxidoreductase activity" EXACT [EC:1.18.1.4]
xref: EC:1.18.1.4
xref: MetaCyc:RUBREDOXIN--NADP+-REDUCTASE-RXN
is_a: GO:0016731 ! oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor

[Term]
id: GO:0015046
name: rubredoxin-NADP reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: reduced rubredoxin + NADP+ = oxidized rubredoxin + NADPH + H+." [EC:1.18.1.-]
subset: gosubset_prok
xref: EC:1.18.1.-
is_a: GO:0016731 ! oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor

[Term]
id: GO:0015047
name: NADPH-cytochrome-c2 reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADPH + H+ + 2 ferricytochrome c2 = NADP+ + 2 ferrocytochrome c2." [EC:1.6.2.5]
synonym: "cytochrome c2 reductase (reduced nicotinamide adinine dinucleotide phosphate, NADPH)" EXACT [EC:1.6.2.5]
synonym: "NADPH:ferricytochrome-c2 oxidoreductase activity" EXACT [EC:1.6.2.5]
synonym: "reductase, cytochrome c2 (reduced nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.6.2.5]
xref: EC:1.6.2.5
xref: MetaCyc:NADPH--CYTOCHROME-C2-REDUCTASE-RXN
is_a: GO:0016653 ! oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor

[Term]
id: GO:0015048
name: phthalate dioxygenase reductase activity
namespace: molecular_function
def: "Catalysis of the transfer of electrons between pyridine nucleotides (obligatory two-electron carriers) and hemes or (2Fe-2S) centers (obligatory one-electron carriers) in respiration, photosynthesis, and many oxygenase systems." [PMID:7589982]
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0015049
name: methane monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: methane + NAD(P)H + H+ + O2 = methanol + NAD(P)+ + H2O." [EC:1.14.13.25]
subset: gosubset_prok
synonym: "methane hydroxylase activity" EXACT [EC:1.14.13.25]
synonym: "methane,NAD(P)H:oxygen oxidoreductase (hydroxylating)" EXACT [EC:1.14.13.25]
xref: EC:1.14.13.25
xref: KEGG:R01142
xref: KEGG:R01143
xref: MetaCyc:METHANE-MONOOXYGENASE-RXN
xref: RHEA:13640
xref: RHEA:13644
xref: UM-BBD_enzymeID:e0007
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0015050
name: methane monooxygenase complex
namespace: cellular_component
def: "A protein complex that possesses methane monooxygenase activity; dimeric and trimeric complexes have been characterized." [BRENDA:1.14.13.25, GOC:mah]
subset: gosubset_prok
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:0015051
name: obsolete X-opioid receptor activity
namespace: molecular_function
def: "OBSOLETE. Combining with an opioid to initiate a change in cell activity, with the pharmacological characteristics of X-opioid receptors." [InterPro:IPR001420]
comment: This term was made obsolete because the receptor is defined based on its pharmacological properties.
synonym: "X-opioid receptor activity" EXACT []
is_obsolete: true
consider: GO:0001626

[Term]
id: GO:0015052
name: beta3-adrenergic receptor activity
namespace: molecular_function
def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta3-adrenergic receptors." [GOC:mah, IUPHAR_GPCR:1274]
synonym: "beta3 adrenoceptor" EXACT []
is_a: GO:0004939 ! beta-adrenergic receptor activity

[Term]
id: GO:0015053
name: obsolete opsin
namespace: molecular_function
def: "OBSOLETE. Hydrophobic glycoprotein to which 11-cis-retinal binds as a Schiff base (in rhodopsin) or 3,4-didehydro-11-cis-retinal binds as a Schiff base in cyanopsin and porphyropsin." [ISBN:0198547684]
comment: This term was made obsolete because it refers to a class of proteins.
synonym: "opsin" EXACT []
is_obsolete: true
consider: GO:0007602
consider: GO:0009881
consider: GO:0016021
consider: GO:0016918
consider: GO:0046876

[Term]
id: GO:0015054
name: gastrin receptor activity
namespace: molecular_function
def: "Combining with gastrin and transmitting the signal across the membrane by activating an associated G-protein to initiate a change in cell activity." [GOC:ai, GOC:signaling]
synonym: "cholecystokinin-B receptor activity" RELATED []
is_a: GO:0008528 ! G-protein coupled peptide receptor activity

[Term]
id: GO:0015055
name: secretin receptor activity
namespace: molecular_function
def: "Combining with secretin to initiate a change in cell activity." [GOC:mah]
is_a: GO:0004930 ! G-protein coupled receptor activity

[Term]
id: GO:0015056
name: corticotrophin-releasing factor receptor activity
namespace: molecular_function
def: "Combining with the corticotrophin-releasing factor family of ligands, including the urocortins, to initiate a change in cell activity." [PMID:12032352]
is_a: GO:0004930 ! G-protein coupled receptor activity
relationship: part_of GO:0071376 ! cellular response to corticotropin-releasing hormone stimulus

[Term]
id: GO:0015057
name: thrombin receptor activity
namespace: molecular_function
alt_id: GO:0010655
def: "Combining with thrombin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state." [GOC:ai]
synonym: "thrombin receptor activity, G-protein coupled" EXACT []
is_a: GO:0008528 ! G-protein coupled peptide receptor activity
relationship: part_of GO:0070493 ! thrombin receptor signaling pathway

[Term]
id: GO:0015058
name: obsolete epidermal growth factor-like module containing hormone receptor activity
namespace: molecular_function
alt_id: GO:0016523
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features.
synonym: "EGF-like module containing hormone receptor activity" EXACT []
synonym: "Egr1 hormone receptor" EXACT []
synonym: "epidermal growth factor-like module containing hormone receptor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0015059
name: obsolete blue-sensitive opsin
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it refers to a class of proteins.
synonym: "blue-sensitive opsin" EXACT []
is_obsolete: true
consider: GO:0007603
consider: GO:0009588
consider: GO:0009881
consider: GO:0016021
consider: GO:0016918
consider: GO:0046876

[Term]
id: GO:0015060
name: obsolete green-sensitive opsin
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it refers to a class of proteins.
synonym: "green-sensitive opsin" EXACT []
is_obsolete: true
consider: GO:0007603
consider: GO:0009881
consider: GO:0016021
consider: GO:0016918
consider: GO:0046876

[Term]
id: GO:0015061
name: obsolete red-sensitive opsin
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it refers to a class of proteins.
synonym: "red-sensitive opsin" EXACT []
is_obsolete: true
consider: GO:0007603
consider: GO:0009585
consider: GO:0009881
consider: GO:0016021
consider: GO:0016918
consider: GO:0046876

[Term]
id: GO:0015062
name: obsolete violet-sensitive opsin
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it refers to a class of proteins.
synonym: "violet-sensitive opsin" EXACT []
is_obsolete: true
consider: GO:0007603
consider: GO:0009588
consider: GO:0009881
consider: GO:0016021
consider: GO:0016918
consider: GO:0046876

[Term]
id: GO:0015063
name: obsolete long-wave-sensitive opsin
namespace: molecular_function
def: "OBSOLETE. An opsin with maximal absorption above 500 nm." [PMID:10594055]
comment: This term was made obsolete because it refers to a class of proteins.
synonym: "long-wave-sensitive opsin" EXACT []
is_obsolete: true
consider: GO:0007603
consider: GO:0009881
consider: GO:0016021
consider: GO:0016918
consider: GO:0046876

[Term]
id: GO:0015064
name: obsolete UV-sensitive opsin
namespace: molecular_function
def: "OBSOLETE. An opsin with maximal absorption below 400 nm." [PMID:10594055]
comment: This term was made obsolete because it refers to a class of proteins.
synonym: "UV-sensitive opsin" EXACT []
is_obsolete: true
consider: GO:0007604
consider: GO:0009881
consider: GO:0016021
consider: GO:0016918
consider: GO:0046876

[Term]
id: GO:0015065
name: uridine nucleotide receptor activity
namespace: molecular_function
def: "Combining with UTP or UDP to initiate a change in cell activity." [GOC:curators, PMID:8537335]
synonym: "purinoceptor type U" EXACT []
is_a: GO:0071553 ! G-protein coupled pyrimidinergic nucleotide receptor activity

[Term]
id: GO:0015066
name: alpha-amylase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of alpha-amylase." [GOC:mah]
subset: gosubset_prok
is_a: GO:0004857 ! enzyme inhibitor activity
relationship: negatively_regulates GO:0004556 ! alpha-amylase activity

[Term]
id: GO:0015067
name: amidinotransferase activity
namespace: molecular_function
def: "Catalysis of the reversible transfer of an amidino group to an acceptor." [GOC:ai]
subset: gosubset_prok
synonym: "transamidinase activity" EXACT []
xref: EC:2.1.4.-
is_a: GO:0016741 ! transferase activity, transferring one-carbon groups
is_a: GO:0016769 ! transferase activity, transferring nitrogenous groups

[Term]
id: GO:0015068
name: glycine amidinotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arginine + glycine = L-ornithine + guanidinoacetate." [EC:2.1.4.1]
subset: gosubset_prok
synonym: "arginine-glycine amidinotransferase activity" EXACT [EC:2.1.4.1]
synonym: "arginine-glycine transamidinase activity" EXACT [EC:2.1.4.1]
synonym: "glycine transamidinase activity" EXACT [EC:2.1.4.1]
synonym: "L-arginine:glycine amidinotransferase activity" EXACT [EC:2.1.4.1]
xref: EC:2.1.4.1
xref: MetaCyc:GLYCINE-AMIDINOTRANSFERASE-RXN
xref: Reactome:REACT_100780 "arginine + glycine => ornithine + guanidoacetate, Xenopus tropicalis"
xref: Reactome:REACT_107410 "arginine + glycine => ornithine + guanidoacetate, Mus musculus"
xref: Reactome:REACT_107725 "arginine + glycine => ornithine + guanidoacetate, Gallus gallus"
xref: Reactome:REACT_108411 "arginine + glycine => ornithine + guanidoacetate, Danio rerio"
xref: Reactome:REACT_30370 "arginine + glycine => ornithine + guanidoacetate, Sus scrofa"
xref: Reactome:REACT_396 "arginine + glycine => ornithine + guanidoacetate, Homo sapiens"
xref: Reactome:REACT_80931 "arginine + glycine => ornithine + guanidoacetate, Canis familiaris"
xref: Reactome:REACT_86466 "arginine + glycine => ornithine + guanidoacetate, Bos taurus"
xref: Reactome:REACT_97935 "arginine + glycine => ornithine + guanidoacetate, Rattus norvegicus"
xref: Reactome:REACT_98720 "arginine + glycine => ornithine + guanidoacetate, Taeniopygia guttata"
xref: RHEA:13204
is_a: GO:0015067 ! amidinotransferase activity

[Term]
id: GO:0015069
name: scyllo-inosamine-4-phosphate amidinotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-amino-1-deoxy-scyllo-inositol 4-phosphate + L-arginine = 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + L-ornithine." [EC:2.1.4.2, RHEA:13268]
subset: gosubset_prok
synonym: "inosamine-P amidinotransferase activity" EXACT [EC:2.1.4.2]
synonym: "inosamine-phosphate amidinotransferase activity" EXACT []
synonym: "L-arginine:1-amino-1-deoxy-scyllo-inositol-4-phosphate amidinotransferase activity" EXACT [EC:2.1.4.2]
synonym: "L-arginine:inosamine phosphate amidinotransferase activity" EXACT [EC:2.1.4.2]
synonym: "L-arginine:inosamine-P-amidinotransferase activity" EXACT [EC:2.1.4.2]
xref: EC:2.1.4.2
xref: KEGG:R03477
xref: MetaCyc:2.1.4.2-RXN
xref: RHEA:13268
is_a: GO:0015067 ! amidinotransferase activity

[Term]
id: GO:0015070
name: obsolete toxin activity
namespace: molecular_function
def: "OBSOLETE. Acts as to cause injury to other living organisms." [GOC:jl]
comment: This term was made obsolete because it represents a classification of molecules and not a molecular function.
synonym: "toxin activity" EXACT []
is_obsolete: true
consider: GO:0009405
consider: GO:0050827

[Term]
id: GO:0015072
name: obsolete phosphatidylinositol 3-kinase, class I, catalyst activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate." [EC:2.7.1.137]
comment: This term was made obsolete because it represents a class of gene products.
synonym: "phosphatidylinositol 3-kinase, class I, catalyst activity" EXACT []
is_obsolete: true
consider: GO:0016303
consider: GO:0035005
consider: GO:0046934

[Term]
id: GO:0015073
name: obsolete phosphatidylinositol 3-kinase, class I, regulator activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate." [EC:2.7.1.137]
comment: This term was made obsolete because it refers to a class of gene products.
synonym: "phosphatidylinositol 3-kinase, class I, regulator activity" EXACT []
is_obsolete: true
replaced_by: GO:0046935

[Term]
id: GO:0015074
name: DNA integration
namespace: biological_process
def: "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0006259 ! DNA metabolic process

[Term]
id: GO:0015075
name: ion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of an ion from one side of a membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "ion transporter activity" EXACT []
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity
relationship: part_of GO:0034220 ! ion transmembrane transport

[Term]
id: GO:0015076
name: obsolete heavy metal ion transporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the directed movement of heavy metal ions into, out of or within a cell, or between cells. Heavy metals are those that can form a coordination bond with a protein, as opposed to an alkali or alkaline-earth metal that can only form an ionic bond; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn." [GOC:ai]
comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information).
synonym: "heavy metal ion transporter activity" EXACT []
is_obsolete: true
consider: GO:0046873

[Term]
id: GO:0015077
name: monovalent inorganic cation transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a inorganic cations with a valency of one from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0022890 ! inorganic cation transmembrane transporter activity
relationship: part_of GO:0015672 ! monovalent inorganic cation transport

[Term]
id: GO:0015078
name: hydrogen ion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of hydrogen ions from one side of a membrane to the other." [GOC:ai]
subset: gosubset_prok
synonym: "proton transporter activity" EXACT []
xref: Reactome:REACT_100267 "Endosome acidification, Bos taurus"
xref: Reactome:REACT_100622 "Endosome acidification, Plasmodium falciparum"
xref: Reactome:REACT_103509 "Protons are translocated from the intermembrane space to the matrix, Taeniopygia guttata"
xref: Reactome:REACT_103825 "Endosome acidification, Gallus gallus"
xref: Reactome:REACT_107684 "Endosome acidification, Rattus norvegicus"
xref: Reactome:REACT_107970 "Protons are translocated from the intermembrane space to the matrix, Bos taurus"
xref: Reactome:REACT_108933 "Protons are translocated from the intermembrane space to the matrix, Oryza sativa"
xref: Reactome:REACT_1985 "Enzyme-bound ATP is released, Homo sapiens"
xref: Reactome:REACT_2002 "Endosome acidification, Homo sapiens"
xref: Reactome:REACT_25268 "Acidification of Tf:TfR1 containing endosome, Homo sapiens"
xref: Reactome:REACT_29417 "Enzyme-bound ATP is released, Bos taurus"
xref: Reactome:REACT_29424 "Protons are translocated from the intermembrane space to the matrix, Gallus gallus"
xref: Reactome:REACT_33554 "Endosome acidification, Schizosaccharomyces pombe"
xref: Reactome:REACT_34522 "Endosome acidification, Sus scrofa"
xref: Reactome:REACT_6312 "Protons are translocated from the intermembrane space to the matrix, Homo sapiens"
xref: Reactome:REACT_77087 "Protons are translocated from the intermembrane space to the matrix, Sus scrofa"
xref: Reactome:REACT_77222 "Enzyme-bound ATP is released, Canis familiaris"
xref: Reactome:REACT_79096 "Endosome acidification, Dictyostelium discoideum"
xref: Reactome:REACT_79130 "Enzyme-bound ATP is released, Mus musculus"
xref: Reactome:REACT_81591 "Endosome acidification, Taeniopygia guttata"
xref: Reactome:REACT_82120 "Enzyme-bound ATP is released, Gallus gallus"
xref: Reactome:REACT_84002 "Endosome acidification, Mus musculus"
xref: Reactome:REACT_86695 "Endosome acidification, Drosophila melanogaster"
xref: Reactome:REACT_87088 "Endosome acidification, Xenopus tropicalis"
xref: Reactome:REACT_88718 "Enzyme-bound ATP is released, Rattus norvegicus"
xref: Reactome:REACT_88914 "Protons are translocated from the intermembrane space to the matrix, Canis familiaris"
xref: Reactome:REACT_89361 "Protons are translocated from the intermembrane space to the matrix, Arabidopsis thaliana"
xref: Reactome:REACT_90226 "Protons are translocated from the intermembrane space to the matrix, Xenopus tropicalis"
xref: Reactome:REACT_91476 "Protons are translocated from the intermembrane space to the matrix, Mus musculus"
xref: Reactome:REACT_93236 "Enzyme-bound ATP is released, Danio rerio"
xref: Reactome:REACT_93447 "Protons are translocated from the intermembrane space to the matrix, Danio rerio"
xref: Reactome:REACT_94558 "Endosome acidification, Danio rerio"
xref: Reactome:REACT_95835 "Endosome acidification, Arabidopsis thaliana"
xref: Reactome:REACT_96838 "Endosome acidification, Saccharomyces cerevisiae"
xref: Reactome:REACT_97023 "Endosome acidification, Caenorhabditis elegans"
xref: Reactome:REACT_97452 "Endosome acidification, Oryza sativa"
xref: Reactome:REACT_97485 "Enzyme-bound ATP is released, Sus scrofa"
xref: Reactome:REACT_98826 "Endosome acidification, Canis familiaris"
xref: Reactome:REACT_99893 "Protons are translocated from the intermembrane space to the matrix, Rattus norvegicus"
is_a: GO:0015077 ! monovalent inorganic cation transmembrane transporter activity
relationship: part_of GO:1902600 ! hydrogen ion transmembrane transport

[Term]
id: GO:0015079
name: potassium ion transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0022817
def: "Enables the transfer of potassium ions (K+) from one side of a membrane to the other." [GOC:ai]
subset: gosubset_prok
synonym: "potassium transporter activity" EXACT []
xref: RHEA:29466
is_a: GO:0015077 ! monovalent inorganic cation transmembrane transporter activity
is_a: GO:0046873 ! metal ion transmembrane transporter activity
relationship: part_of GO:0071805 ! potassium ion transmembrane transport

[Term]
id: GO:0015080
name: silver ion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of silver (Ag) ions from one side of a membrane to the other." [GOC:ai]
synonym: "silver transporter activity" EXACT []
is_a: GO:0015077 ! monovalent inorganic cation transmembrane transporter activity
is_a: GO:0046915 ! transition metal ion transmembrane transporter activity
relationship: part_of GO:1902601 ! silver ion transmembrane transport

[Term]
id: GO:0015081
name: sodium ion transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0022816
def: "Enables the transfer of sodium ions (Na+) from one side of a membrane to the other." [GOC:ai, GOC:BHF]
subset: gosubset_prok
synonym: "sodium transporter activity" EXACT []
is_a: GO:0015077 ! monovalent inorganic cation transmembrane transporter activity
is_a: GO:0046873 ! metal ion transmembrane transporter activity
relationship: part_of GO:0035725 ! sodium ion transmembrane transport

[Term]
id: GO:0015083
name: aluminum ion transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015084
def: "Enables the transfer of aluminum (Al) ions from one side of a membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "aluminium ion transporter activity" EXACT []
synonym: "aluminium resistance permease activity" EXACT []
synonym: "aluminum resistance permease activity" EXACT []
is_a: GO:0046873 ! metal ion transmembrane transporter activity
is_a: GO:0072510 ! trivalent inorganic cation transmembrane transporter activity
relationship: part_of GO:1902602 ! aluminum ion transmembrane transport

[Term]
id: GO:0015085
name: calcium ion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of calcium (Ca) ions from one side of a membrane to the other." [GOC:dgf]
subset: gosubset_prok
is_a: GO:0046873 ! metal ion transmembrane transporter activity
is_a: GO:0072509 ! divalent inorganic cation transmembrane transporter activity
relationship: part_of GO:0070588 ! calcium ion transmembrane transport

[Term]
id: GO:0015086
name: cadmium ion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of cadmium (Cd) ions from one side of a membrane to the other." [GOC:dgf]
subset: gosubset_prok
synonym: "zinc, cadmium uptake permease activity" RELATED []
synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" RELATED []
is_a: GO:0046915 ! transition metal ion transmembrane transporter activity
is_a: GO:0072509 ! divalent inorganic cation transmembrane transporter activity
relationship: part_of GO:0070574 ! cadmium ion transmembrane transport

[Term]
id: GO:0015087
name: cobalt ion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of cobalt (Co) ions from one side of a membrane to the other." [GOC:dgf]
subset: gosubset_prok
synonym: "cobalt, zinc uptake permease activity" RELATED []
synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" RELATED []
xref: RHEA:28581
is_a: GO:0046915 ! transition metal ion transmembrane transporter activity
relationship: part_of GO:0006824 ! cobalt ion transport

[Term]
id: GO:0015088
name: copper uptake transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Cu+(out) = Cu+(in)." [TC:9.A.12.-.-]
is_a: GO:0005375 ! copper ion transmembrane transporter activity

[Term]
id: GO:0015089
name: high-affinity copper ion transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Cu2+(out) = Cu2+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [TC:9.A.11.1.1]
synonym: "high affinity copper ion transmembrane transporter activity" EXACT []
synonym: "high affinity copper transporter activity" EXACT []
is_a: GO:0005375 ! copper ion transmembrane transporter activity

[Term]
id: GO:0015090
name: low-affinity iron ion transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Fe2+(out) = Fe2+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [TC:9.A.9.1.1]
synonym: "low affinity iron ion transmembrane transporter activity" EXACT []
synonym: "low affinity iron transporter activity" EXACT []
is_a: GO:0005381 ! iron ion transmembrane transporter activity
relationship: part_of GO:0000040 ! low-affinity iron ion transmembrane transport

[Term]
id: GO:0015091
name: ferric iron transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of ferric iron (Fe(III) or Fe3+) ions from one side of a membrane to the other." [ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0005381 ! iron ion transmembrane transporter activity
is_a: GO:0072510 ! trivalent inorganic cation transmembrane transporter activity
relationship: part_of GO:0015682 ! ferric iron transport

[Term]
id: GO:0015092
name: high-affinity ferric uptake transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of Fe(III) from the outside of a cell to the inside of a cell across a membrane. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:ai, TC:9.A.10.1.1]
synonym: "high affinity ferric uptake transmembrane transporter activity" EXACT []
is_a: GO:0015091 ! ferric iron transmembrane transporter activity
relationship: part_of GO:0015683 ! high-affinity ferric iron transport

[Term]
id: GO:0015093
name: ferrous iron transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of ferrous iron (Fe(II) or Fe2+) ions from one side of a membrane to the other." [ISBN:0198506732]
subset: gosubset_prok
xref: RHEA:28489
is_a: GO:0005381 ! iron ion transmembrane transporter activity
is_a: GO:0072509 ! divalent inorganic cation transmembrane transporter activity
relationship: part_of GO:0015684 ! ferrous iron transport
relationship: part_of GO:1903874 ! ferrous iron transmembrane transport

[Term]
id: GO:0015094
name: lead ion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of lead (Pb) ions from one side of a membrane to the other." [GOC:ai]
subset: gosubset_prok
synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" RELATED []
is_a: GO:0046873 ! metal ion transmembrane transporter activity
is_a: GO:0072509 ! divalent inorganic cation transmembrane transporter activity
relationship: part_of GO:0015692 ! lead ion transport

[Term]
id: GO:0015095
name: magnesium ion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of magnesium (Mg) ions from one side of a membrane to the other." [GOC:dgf]
subset: gosubset_prok
xref: Reactome:REACT_20680 "MagT transporters mediate magnesium uptake into cells, Homo sapiens"
xref: RHEA:29830
is_a: GO:0046873 ! metal ion transmembrane transporter activity
is_a: GO:0072509 ! divalent inorganic cation transmembrane transporter activity
relationship: part_of GO:1903830 ! magnesium ion transmembrane transport

[Term]
id: GO:0015096
name: obsolete manganese resistance permease activity
namespace: molecular_function
def: "OBSOLETE." [GOC:mtg_transport]
comment: This term was made obsolete because the term is undefined and we don't know the mechanism so we can't make a correct definition.
synonym: "manganese resistance permease activity" EXACT []
is_obsolete: true

[Term]
id: GO:0015097
name: mercury ion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of mercury (Hg) ions from one side of a membrane to the other." [GOC:ai]
subset: gosubset_prok
xref: RHEA:32818
is_a: GO:0046915 ! transition metal ion transmembrane transporter activity
is_a: GO:0072509 ! divalent inorganic cation transmembrane transporter activity
relationship: part_of GO:0015694 ! mercury ion transport

[Term]
id: GO:0015098
name: molybdate ion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of molybdate (MoO4 2-) ions from one side of a membrane to the other. Molybdate is the bivalent anion derived from molybdic acid." [ISBN:0198506732]
subset: gosubset_prok
synonym: "molybdate transporter activity" EXACT []
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity
relationship: part_of GO:0015689 ! molybdate ion transport

[Term]
id: GO:0015099
name: nickel cation transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of nickel (Ni) cations from one side of a membrane to the other." [GOC:ai]
subset: gosubset_prok
synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" RELATED []
xref: RHEA:29834
is_a: GO:0046915 ! transition metal ion transmembrane transporter activity
relationship: part_of GO:0035444 ! nickel cation transmembrane transport

[Term]
id: GO:0015100
name: vanadium ion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of vanadium (V) ions from one side of a membrane to the other." [GOC:ai]
is_a: GO:0046915 ! transition metal ion transmembrane transporter activity
relationship: part_of GO:0015676 ! vanadium ion transport

[Term]
id: GO:0015101
name: organic cation transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
xref: Reactome:REACT_22167 "OCT3 mediates renal uptake of organic cations, Homo sapiens"
xref: Reactome:REACT_22221 "OCT1 transports organic cations into hepatic cells, Homo sapiens"
xref: Reactome:REACT_22283 "OCT2 mediates tubular uptake of organic cations in the kidney, Homo sapiens"
xref: Reactome:REACT_22327 "OCT2 mediates tubular secretion of organic cations in the kidney, Homo sapiens"
xref: Reactome:REACT_22348 "OCT1 transports organic cations out of hepatic cells, Homo sapiens"
xref: Reactome:REACT_22373 "OCT3 mediates renal clearance of organic cations, Homo sapiens"
is_a: GO:0008324 ! cation transmembrane transporter activity
relationship: part_of GO:0015695 ! organic cation transport

[Term]
id: GO:0015103
name: inorganic anion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of inorganic anions from one side of a membrane to the other. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008509 ! anion transmembrane transporter activity
relationship: part_of GO:0015698 ! inorganic anion transport

[Term]
id: GO:0015104
name: antimonite transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of antimonite from one side of a membrane to the other." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity
relationship: part_of GO:0015699 ! antimonite transport

[Term]
id: GO:0015105
name: arsenite transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of arsenite from one side of a membrane to the other." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity

[Term]
id: GO:0015106
name: bicarbonate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-." [GOC:ai]
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity
relationship: part_of GO:0015701 ! bicarbonate transport

[Term]
id: GO:0015107
name: chlorate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of chlorate, ClO3-, from one side of a membrane to the other." [CHEBI:49709, GOC:curators]
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity
relationship: part_of GO:0015702 ! chlorate transport

[Term]
id: GO:0015108
name: chloride transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of chloride ions from one side of a membrane to the other." [GOC:ai]
subset: gosubset_prok
synonym: "chloride ion transmembrane transporter activity" EXACT [GOC:pr]
xref: RHEA:29826
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity
relationship: part_of GO:0006821 ! chloride transport
relationship: part_of GO:1902476 ! chloride transmembrane transport

[Term]
id: GO:0015109
name: chromate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of chromate from one side of a membrane to the other. Chromate is the anion of chromic acid, H2CrO4 (aq) or CrO3." [GOC:ai]
subset: gosubset_prok
xref: RHEA:32822
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity
relationship: part_of GO:0015703 ! chromate transport

[Term]
id: GO:0015110
name: cyanate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of cyanate, NCO-, the anion of cyanic acid, from one side of a membrane to the other." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity
relationship: part_of GO:0015704 ! cyanate transport

[Term]
id: GO:0015111
name: iodide transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of iodide ions from one side of a membrane to the other." [GOC:ai]
xref: Reactome:REACT_101874 "Iodide is taken up by thyroid epithelial cells, Rattus norvegicus"
xref: Reactome:REACT_104008 "Iodide is taken up by thyroid epithelial cells, Staphylococcus aureus N315"
xref: Reactome:REACT_109177 "Iodide is taken up by thyroid epithelial cells, Bos taurus"
xref: Reactome:REACT_15327 "Iodide is taken up by thyroid epithelial cells, Homo sapiens"
xref: Reactome:REACT_32519 "Iodide is taken up by thyroid epithelial cells, Sus scrofa"
xref: Reactome:REACT_63210 "Iodide is taken up by thyroid epithelial cells, Gallus gallus"
xref: Reactome:REACT_78000 "Iodide is taken up by thyroid epithelial cells, Danio rerio"
xref: Reactome:REACT_90970 "Iodide is taken up by thyroid epithelial cells, Xenopus tropicalis"
xref: Reactome:REACT_91130 "Iodide is taken up by thyroid epithelial cells, Mus musculus"
xref: Reactome:REACT_98206 "Iodide is taken up by thyroid epithelial cells, Canis familiaris"
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity
relationship: part_of GO:0015705 ! iodide transport

[Term]
id: GO:0015112
name: nitrate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of nitrate ions (NO3-) from one side of a membrane to the other." [GOC:ai]
subset: gosubset_prok
synonym: "nitrite/nitrate porter activity" RELATED []
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity
relationship: part_of GO:0015706 ! nitrate transport

[Term]
id: GO:0015113
name: nitrite transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of nitrite (NO2-) ions from one side of a membrane to the other." [GOC:ai]
subset: gosubset_prok
synonym: "nitrite/nitrate porter activity" RELATED []
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity
relationship: part_of GO:0015707 ! nitrite transport

[Term]
id: GO:0015114
name: phosphate ion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other." [GOC:ai]
subset: gosubset_prok
synonym: "phosphate transmembrane transporter activity" RELATED [GOC:vw]
xref: RHEA:32826
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity
relationship: part_of GO:0035435 ! phosphate ion transmembrane transport

[Term]
id: GO:0015115
name: silicate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of silicates from one side of a membrane to the other. Silicates are the salts of silicic acids, and are usually composed of silicon and oxygen (Si[x]O[y]), one or more metals, and possibly hydrogen. Types of silicate include unisilicates, metasilicates and hydrous silicates." [CHEBI:48123, GOC:ai]
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity
relationship: part_of GO:0015708 ! silicate transport

[Term]
id: GO:0015116
name: sulfate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other." [GOC:ai]
subset: gosubset_prok
synonym: "sulfate permease activity" RELATED []
synonym: "sulphate transporter activity" EXACT []
xref: Reactome:REACT_102278 "Group 1 - Sulphate transport, Xenopus tropicalis"
xref: Reactome:REACT_103619 "Group 1 - Sulphate transport, Mus musculus"
xref: Reactome:REACT_106359 "Group 1 - Sulphate transport, Arabidopsis thaliana"
xref: Reactome:REACT_113041 "Group 1 - Sulphate transport, Plasmodium falciparum"
xref: Reactome:REACT_113869 "Group 1 - Sulphate transport, Dictyostelium discoideum"
xref: Reactome:REACT_19330 "Group 1 - Sulphate transport, Homo sapiens"
xref: Reactome:REACT_28333 "Group 1 - Sulphate transport, Bos taurus"
xref: Reactome:REACT_32751 "Group 1 - Sulphate transport, Mycobacterium tuberculosis"
xref: Reactome:REACT_32988 "Group 1 - Sulphate transport, Danio rerio"
xref: Reactome:REACT_32996 "Group 1 - Sulphate transport, Sus scrofa"
xref: Reactome:REACT_81210 "Group 1 - Sulphate transport, Oryza sativa"
xref: Reactome:REACT_84743 "Group 1 - Sulphate transport, Gallus gallus"
xref: Reactome:REACT_85109 "Group 1 - Sulphate transport, Canis familiaris"
xref: Reactome:REACT_95961 "Group 1 - Sulphate transport, Taeniopygia guttata"
xref: Reactome:REACT_98485 "Group 1 - Sulphate transport, Rattus norvegicus"
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity
is_a: GO:1901682 ! sulfur compound transmembrane transporter activity
relationship: part_of GO:1902358 ! sulfate transmembrane transport

[Term]
id: GO:0015117
name: thiosulfate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of thiosulfate ions, S2O3(2-), from one side of a membrane to the other." [GOC:ai]
subset: gosubset_prok
synonym: "thiosulfate permease activity" RELATED []
synonym: "thiosulphate transporter activity" EXACT []
xref: RHEA:32810
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity
is_a: GO:1901682 ! sulfur compound transmembrane transporter activity

[Term]
id: GO:0015118
name: tellurite transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of tellurite from one side of a membrane to the other. Tellurite is a salt of tellurous acid or an oxide of tellurium which occurs sparingly in tufts of white or yellowish crystals." [CHEBI:30477, GOC:ai]
subset: gosubset_prok
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity
relationship: part_of GO:0015710 ! tellurite transport

[Term]
id: GO:0015119
name: hexose phosphate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of hexose phosphate from one side of the membrane to the other. Hexose phosphates is any of a group of monophosphorylated aldoses with a chain of six carbon atoms in the molecule." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity
is_a: GO:1901505 ! carbohydrate derivative transporter activity

[Term]
id: GO:0015120
name: phosphoglycerate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of phosphoglycerates from one side of the membrane to the other. Phosphoglycerates are important intermediates in glycolysis and 3-phosphoglycerate is a precursor in serine biosynthesis." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity
is_a: GO:0042879 ! aldonate transmembrane transporter activity
is_a: GO:1901505 ! carbohydrate derivative transporter activity
relationship: part_of GO:0015713 ! phosphoglycerate transport

[Term]
id: GO:0015121
name: phosphoenolpyruvate:phosphate antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phosphoenolpyruvate(out) + phosphate(in) = phosphoenolpyruvate(in) + phosphate(out)." [GOC:bf, GOC:jl]
synonym: "phosphoenolpyruvate/phosphate translocator" EXACT []
synonym: "PPT" BROAD [PMID:10488230]
is_a: GO:0015301 ! anion:anion antiporter activity
is_a: GO:0089721 ! phosphoenolpyruvate transmembrane transporter activity

[Term]
id: GO:0015123
name: acetate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of acetate from one side of the membrane to the other. Acetate is the 2-carbon carboxylic acid ethanoic acid." [GOC:ai]
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
relationship: part_of GO:0035433 ! acetate transmembrane transport

[Term]
id: GO:0015124
name: allantoate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of allantoate from one side of the membrane to the other. Allantoate is the end product of purine metabolism in mammals and some fish, formed form allantoin. It is widely distributed in plants as an important source of stored nitrogen." [GOC:ai, ISBN:0198547684]
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:0042887 ! amide transmembrane transporter activity
relationship: part_of GO:0015719 ! allantoate transport

[Term]
id: GO:0015125
name: bile acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of bile acid from one side of the membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine." [GOC:ai]
xref: Reactome:REACT_10072 "Transport (influx) of bile salts and acids by OATP-A, Homo sapiens"
xref: Reactome:REACT_10091 "Transport (influx) of glycocholate and taurocholate by OATP-C, Homo sapiens"
xref: Reactome:REACT_10124 "Transport (influx) of glycocholate and taurocholate by OATP-8, Homo sapiens"
xref: Reactome:REACT_104269 "Transport (influx) of bile salts and acids by OATP-A, Rattus norvegicus"
xref: Reactome:REACT_113507 "Transport (influx) of bile salts and acids by OATP-A, Danio rerio"
xref: Reactome:REACT_114243 "Transport (influx) of glycocholate and taurocholate by OATP-C, Danio rerio"
xref: Reactome:REACT_114986 "Transport (influx) of glycocholate and taurocholate by OATP-8, Danio rerio"
xref: Reactome:REACT_28051 "Transport (influx) of glycocholate and taurocholate by OATP-C, Bos taurus"
xref: Reactome:REACT_29908 "Transport (influx) of bile salts and acids by OATP-A, Taeniopygia guttata"
xref: Reactome:REACT_30509 "Transport (influx) of glycocholate and taurocholate by OATP-8, Xenopus tropicalis"
xref: Reactome:REACT_32328 "Transport (influx) of bile salts and acids by OATP-A, Bos taurus"
xref: Reactome:REACT_77753 "Transport (influx) of glycocholate and taurocholate by OATP-C, Xenopus tropicalis"
xref: Reactome:REACT_84038 "Transport (influx) of glycocholate and taurocholate by OATP-8, Taeniopygia guttata"
xref: Reactome:REACT_84286 "Transport (influx) of glycocholate and taurocholate by OATP-C, Mus musculus"
xref: Reactome:REACT_85175 "Transport (influx) of glycocholate and taurocholate by OATP-8, Bos taurus"
xref: Reactome:REACT_87766 "Transport (influx) of bile salts and acids by OATP-A, Canis familiaris"
xref: Reactome:REACT_87836 "Transport (influx) of bile salts and acids by OATP-A, Sus scrofa"
xref: Reactome:REACT_88859 "Transport (influx) of glycocholate and taurocholate by OATP-8, Canis familiaris"
xref: Reactome:REACT_89045 "Transport (influx) of glycocholate and taurocholate by OATP-C, Canis familiaris"
xref: Reactome:REACT_89404 "Transport (influx) of glycocholate and taurocholate by OATP-8, Mus musculus"
xref: Reactome:REACT_89951 "Transport (influx) of glycocholate and taurocholate by OATP-C, Rattus norvegicus"
xref: Reactome:REACT_90853 "Transport (influx) of glycocholate and taurocholate by OATP-C, Taeniopygia guttata"
xref: Reactome:REACT_95061 "Transport (influx) of bile salts and acids by OATP-A, Mus musculus"
xref: Reactome:REACT_99850 "Transport (influx) of glycocholate and taurocholate by OATP-8, Rattus norvegicus"
is_a: GO:0005319 ! lipid transporter activity
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity
relationship: part_of GO:0015721 ! bile acid and bile salt transport

[Term]
id: GO:0015126
name: canalicular bile acid transmembrane transporter activity
namespace: molecular_function
def: "The directed movement of bile acid and bile salts out of a hepatocyte and into the bile canaliculus by means of an agent such as a transporter or pore. Bile canaliculi are the thin tubes formed by hepatocyte membranes. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine." [GOC:dph]
is_a: GO:0015125 ! bile acid transmembrane transporter activity
relationship: part_of GO:0015722 ! canalicular bile acid transport

[Term]
id: GO:0015127
name: bilirubin transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of bilirubin from one side of the membrane to the other. Bilirubin is a linear tetrapyrrole produced in the reticuloendothelial system from biliverdin and transported to the liver as a complex with serum albumin. In the liver, bilirubin is converted to bilirubin bisglucuronide, which is excreted in the bile." [GOC:ai, ISBN:0198547684]
is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity
relationship: part_of GO:0015723 ! bilirubin transport

[Term]
id: GO:0015128
name: gluconate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of gluconate from one side of the membrane to the other. Gluconate is the aldonic acid derived from glucose." [GOC:ai, ISBN:0198506732]
subset: gosubset_prok
synonym: "L-idonate/D-gluconate:hydrogen symporter activity" NARROW []
is_a: GO:0042879 ! aldonate transmembrane transporter activity
relationship: part_of GO:0035429 ! gluconate transmembrane transport

[Term]
id: GO:0015129
name: lactate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of lactate from one side of the membrane to the other. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices." [GOC:ai, ISBN:0198506732]
subset: gosubset_prok
synonym: "monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity" RELATED []
xref: Reactome:REACT_101266 "lactate + H+ [cytosol] <=> lactate + H+ [extracellular], Bos taurus"
xref: Reactome:REACT_103370 "lactate + H+ [cytosol] <=> lactate + H+ [extracellular], Mus musculus"
xref: Reactome:REACT_103772 "lactate + H+ [extracellular] <=> lactate + H+ [cytosol], Xenopus tropicalis"
xref: Reactome:REACT_106242 "lactate + H+ [cytosol] <=> lactate + H+ [extracellular], Gallus gallus"
xref: Reactome:REACT_106948 "lactate + H+ [cytosol] <=> lactate + H+ [extracellular], Xenopus tropicalis"
xref: Reactome:REACT_107824 "lactate + H+ [cytosol] <=> lactate + H+ [extracellular], Taeniopygia guttata"
xref: Reactome:REACT_109270 "lactate + H+ [extracellular] <=> lactate + H+ [cytosol], Danio rerio"
xref: Reactome:REACT_112882 "lactate + H+ [cytosol] <=> lactate + H+ [extracellular], Drosophila melanogaster"
xref: Reactome:REACT_113117 "lactate + H+ [extracellular] <=> lactate + H+ [cytosol], Drosophila melanogaster"
xref: Reactome:REACT_115838 "lactate + H+ [cytosol] <=> lactate + H+ [extracellular], Gallus gallus"
xref: Reactome:REACT_115933 "lactate + H+ [extracellular] <=> lactate + H+ [cytosol], Gallus gallus"
xref: Reactome:REACT_14839 "lactate + H+ [cytosol] <=> lactate + H+ [extracellular], Homo sapiens"
xref: Reactome:REACT_14855 "lactate + H+ [extracellular] <=> lactate + H+ [cytosol], Homo sapiens"
xref: Reactome:REACT_78109 "lactate + H+ [extracellular] <=> lactate + H+ [cytosol], Taeniopygia guttata"
xref: Reactome:REACT_83653 "lactate + H+ [cytosol] <=> lactate + H+ [extracellular], Danio rerio"
xref: Reactome:REACT_84195 "lactate + H+ [extracellular] <=> lactate + H+ [cytosol], Gallus gallus"
xref: Reactome:REACT_84317 "lactate + H+ [extracellular] <=> lactate + H+ [cytosol], Mus musculus"
xref: Reactome:REACT_88321 "lactate + H+ [extracellular] <=> lactate + H+ [cytosol], Canis familiaris"
xref: Reactome:REACT_94824 "lactate + H+ [extracellular] <=> lactate + H+ [cytosol], Bos taurus"
xref: Reactome:REACT_96863 "lactate + H+ [cytosol] <=> lactate + H+ [extracellular], Canis familiaris"
xref: Reactome:REACT_98005 "lactate + H+ [extracellular] <=> lactate + H+ [cytosol], Rattus norvegicus"
xref: Reactome:REACT_98579 "lactate + H+ [cytosol] <=> lactate + H+ [extracellular], Rattus norvegicus"
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity
relationship: part_of GO:0035873 ! lactate transmembrane transport

[Term]
id: GO:0015130
name: mevalonate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of mevalonate from one side of the membrane to the other. Mevalonate is the anion of mevalonic acid; its (R)-enantiomer is a strategic intermediate derived from hydroxymethylglutaryl-CoA in the biosynthesis of polyprenyl compounds." [GOC:ai, ISBN:0198506732]
synonym: "monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity" RELATED []
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity
relationship: part_of GO:0015728 ! mevalonate transport

[Term]
id: GO:0015131
name: oxaloacetate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of oxaloacetate, the anion of oxobutanedioic acid, from one side of the membrane to the other." [GOC:ai]
is_a: GO:0015556 ! C4-dicarboxylate transmembrane transporter activity
relationship: part_of GO:0015729 ! oxaloacetate transport
relationship: part_of GO:1902356 ! oxaloacetate(2-) transmembrane transport

[Term]
id: GO:0015132
name: prostaglandin transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of prostaglandins from one side of the membrane to the other. A prostaglandin is any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities." [GOC:ai]
synonym: "prostaglandin/thromboxane transporter activity" BROAD []
xref: Reactome:REACT_23779 "PGT transports prostaglandins, Homo sapiens"
is_a: GO:0071714 ! icosanoid transmembrane transporter activity
relationship: part_of GO:0015732 ! prostaglandin transport

[Term]
id: GO:0015133
name: uronic acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of uronic acid from one side of the membrane to the other. Uronic acids are any monocarboxylic acid formally derived by oxidizing to a carboxyl group the terminal hydroxymethylene group of either an aldose with four or more carbon atoms in the molecule, or of any glycoside derived from such an aldose." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:0015145 ! monosaccharide transmembrane transporter activity
relationship: part_of GO:0015735 ! uronic acid transport

[Term]
id: GO:0015134
name: hexuronate transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015163
def: "Enables the transfer of hexuronates from one side of the membrane to the other. A hexuronate is any monocarboxylic acid derived from a hexose by oxidation of C-6." [GOC:ai, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
subset: gosubset_prok
synonym: "hexuronide transmembrane transporter activity" EXACT []
is_a: GO:0015133 ! uronic acid transmembrane transporter activity
relationship: part_of GO:0015736 ! hexuronate transport
relationship: part_of GO:0015778 ! hexuronide transport

[Term]
id: GO:0015135
name: glucuronate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of glucuronate from one side of the membrane to the other. Glucuronate is the uronic acid formally derived from glucose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group." [GOC:ai]
is_a: GO:0015134 ! hexuronate transmembrane transporter activity
relationship: part_of GO:0015738 ! glucuronate transport

[Term]
id: GO:0015136
name: sialic acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of sialic acid from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity
is_a: GO:1901505 ! carbohydrate derivative transporter activity

[Term]
id: GO:0015137
name: citrate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of the membrane to the other." [GOC:ai]
subset: gosubset_prok
xref: Reactome:REACT_102037 "NACT co-transports trivalent citrate and a sodium ion, Bos taurus"
xref: Reactome:REACT_102678 "NACT co-transports trivalent citrate and a sodium ion, Staphylococcus aureus N315"
xref: Reactome:REACT_104138 "NACT co-transports trivalent citrate and a sodium ion, Gallus gallus"
xref: Reactome:REACT_106438 "NACT co-transports trivalent citrate and a sodium ion, Taeniopygia guttata"
xref: Reactome:REACT_109129 "NACT co-transports trivalent citrate and a sodium ion, Sus scrofa"
xref: Reactome:REACT_109766 "NACT co-transports trivalent citrate and a sodium ion, Oryza sativa"
xref: Reactome:REACT_20529 "NACT co-transports trivalent citrate and a sodium ion, Homo sapiens"
xref: Reactome:REACT_81510 "NACT co-transports trivalent citrate and a sodium ion, Arabidopsis thaliana"
xref: Reactome:REACT_81718 "NACT co-transports trivalent citrate and a sodium ion, Mus musculus"
xref: Reactome:REACT_84747 "NACT co-transports trivalent citrate and a sodium ion, Caenorhabditis elegans"
xref: Reactome:REACT_90556 "NACT co-transports trivalent citrate and a sodium ion, Drosophila melanogaster"
xref: Reactome:REACT_92184 "NACT co-transports trivalent citrate and a sodium ion, Xenopus tropicalis"
xref: Reactome:REACT_94381 "NACT co-transports trivalent citrate and a sodium ion, Danio rerio"
xref: Reactome:REACT_97361 "NACT co-transports trivalent citrate and a sodium ion, Canis familiaris"
xref: Reactome:REACT_99461 "NACT co-transports trivalent citrate and a sodium ion, Rattus norvegicus"
is_a: GO:0015142 ! tricarboxylic acid transmembrane transporter activity
relationship: part_of GO:0015746 ! citrate transport

[Term]
id: GO:0015138
name: fumarate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of fumarate from one side of the membrane to the other. Fumarate is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate." [GOC:ai]
synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity" RELATED []
is_a: GO:0015556 ! C4-dicarboxylate transmembrane transporter activity
relationship: part_of GO:0015741 ! fumarate transport

[Term]
id: GO:0015139
name: alpha-ketoglutarate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of alpha-ketoglutarate from one side of the membrane to the other. Alpha-ketoglutarate (or oxoglutarate) is a compound with important roles in carbohydrate and amino acid metabolism, especially in transamination reactions and as a component of the TCA cycle." [GOC:ai, ISBN:0198547684]
subset: gosubset_prok
synonym: "2-oxoglutarate transporter activity" EXACT []
xref: Reactome:REACT_102427 "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix], Rattus norvegicus"
xref: Reactome:REACT_108381 "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix], Drosophila melanogaster"
xref: Reactome:REACT_109405 "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix], Dictyostelium discoideum"
xref: Reactome:REACT_110136 "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix], Canis familiaris"
xref: Reactome:REACT_115728 "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix], Gallus gallus"
xref: Reactome:REACT_14838 "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix], Homo sapiens"
xref: Reactome:REACT_30727 "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix], Mus musculus"
xref: Reactome:REACT_79624 "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix], Schizosaccharomyces pombe"
xref: Reactome:REACT_84635 "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix], Taeniopygia guttata"
xref: Reactome:REACT_86882 "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix], Gallus gallus"
xref: Reactome:REACT_88961 "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix], Saccharomyces cerevisiae"
xref: Reactome:REACT_89809 "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix], Danio rerio"
xref: Reactome:REACT_93135 "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix], Xenopus tropicalis"
xref: Reactome:REACT_94339 "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix], Bos taurus"
xref: Reactome:REACT_96252 "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix], Caenorhabditis elegans"
xref: Reactome:REACT_96485 "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix], Sus scrofa"
is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity
relationship: part_of GO:0015742 ! alpha-ketoglutarate transport

[Term]
id: GO:0015140
name: malate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of malate from one side of the membrane to the other. Malate is a chiral hydroxydicarboxylic acid, hydroxybutanedioic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle." [GOC:ai]
synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity" RELATED []
is_a: GO:0015556 ! C4-dicarboxylate transmembrane transporter activity
relationship: part_of GO:0071423 ! malate transmembrane transport

[Term]
id: GO:0015141
name: succinate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of succinate, the dianion of ethane dicarboxylic acid, from one side of the membrane to the other." [ISBN:0198506732]
subset: gosubset_prok
synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity" RELATED []
is_a: GO:0015556 ! C4-dicarboxylate transmembrane transporter activity
relationship: part_of GO:0071422 ! succinate transmembrane transport

[Term]
id: GO:0015142
name: tricarboxylic acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of tricarboxylic acids from one side of the membrane to the other. Tricarboxylic acid are organic acids with three COOH groups." [GOC:ai]
subset: gosubset_prok
synonym: "sodium:dicarboxylate/tricarboxylate symporter activity" NARROW []
xref: Reactome:REACT_100083 "phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix], Drosophila melanogaster"
xref: Reactome:REACT_100718 "Transport of Citrate from Mitochondrial Matrix to cytosol, Canis familiaris"
xref: Reactome:REACT_102576 "phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix], Saccharomyces cerevisiae"
xref: Reactome:REACT_102592 "Transport of Citrate from Mitochondrial Matrix to cytosol, Bos taurus"
xref: Reactome:REACT_105256 "Transport of Citrate from Mitochondrial Matrix to cytosol, Drosophila melanogaster"
xref: Reactome:REACT_105672 "Transport of Citrate from Mitochondrial Matrix to cytosol, Sus scrofa"
xref: Reactome:REACT_108014 "Transport of Citrate from Mitochondrial Matrix to cytosol, Rattus norvegicus"
xref: Reactome:REACT_108369 "phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix], Gallus gallus"
xref: Reactome:REACT_110146 "Transport of Citrate from Mitochondrial Matrix to cytosol, Schizosaccharomyces pombe"
xref: Reactome:REACT_115821 "phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] <=> phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix], Gallus gallus"
xref: Reactome:REACT_14780 "phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix], Homo sapiens"
xref: Reactome:REACT_1605 "Transport of Citrate from Mitochondrial Matrix to cytosol, Homo sapiens"
xref: Reactome:REACT_28706 "Transport of Citrate from Mitochondrial Matrix to cytosol, Arabidopsis thaliana"
xref: Reactome:REACT_29749 "Transport of Citrate from Mitochondrial Matrix to cytosol, Danio rerio"
xref: Reactome:REACT_32252 "phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix], Rattus norvegicus"
xref: Reactome:REACT_32393 "phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix], Dictyostelium discoideum"
xref: Reactome:REACT_33746 "Transport of Citrate from Mitochondrial Matrix to cytosol, Saccharomyces cerevisiae"
xref: Reactome:REACT_34074 "phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix], Canis familiaris"
xref: Reactome:REACT_77719 "phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix], Xenopus tropicalis"
xref: Reactome:REACT_79743 "phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix], Schizosaccharomyces pombe"
xref: Reactome:REACT_79987 "Transport of Citrate from Mitochondrial Matrix to cytosol, Dictyostelium discoideum"
xref: Reactome:REACT_81454 "phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix], Taeniopygia guttata"
xref: Reactome:REACT_82513 "Transport of Citrate from Mitochondrial Matrix to cytosol, Caenorhabditis elegans"
xref: Reactome:REACT_82573 "Transport of Citrate from Mitochondrial Matrix to cytosol, Oryza sativa"
xref: Reactome:REACT_82576 "Transport of Citrate from Mitochondrial Matrix to cytosol, Gallus gallus"
xref: Reactome:REACT_84249 "phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix], Sus scrofa"
xref: Reactome:REACT_87268 "Transport of Citrate from Mitochondrial Matrix to cytosol, Taeniopygia guttata"
xref: Reactome:REACT_87426 "phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix], Danio rerio"
xref: Reactome:REACT_91401 "phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix], Caenorhabditis elegans"
xref: Reactome:REACT_91573 "Transport of Citrate from Mitochondrial Matrix to cytosol, Mus musculus"
xref: Reactome:REACT_92832 "Transport of Citrate from Mitochondrial Matrix to cytosol, Xenopus tropicalis"
xref: Reactome:REACT_93633 "phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix], Arabidopsis thaliana"
xref: Reactome:REACT_95713 "phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix], Oryza sativa"
xref: Reactome:REACT_97334 "phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix], Mus musculus"
xref: Reactome:REACT_99396 "phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix], Bos taurus"
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity
relationship: part_of GO:0035674 ! tricarboxylic acid transmembrane transport

[Term]
id: GO:0015143
name: urate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of urate from one side of the membrane to the other. Urate is the anion of uric acid, 2,6,8-trioxypurine, the end product of purine metabolism in certain mammals and the main excretory product in uricotelic animals." [GOC:ai]
synonym: "uric acid transmembrane transporter activity" EXACT []
xref: Reactome:REACT_22238 "URAT1 regulates urate levels in blood with exchange for organic anions, Homo sapiens"
is_a: GO:0005342 ! organic acid transmembrane transporter activity
is_a: GO:1901702 ! salt transmembrane transporter activity

[Term]
id: GO:0015144
name: carbohydrate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of carbohydrate from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "sugar transporter" NARROW []
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity
is_a: GO:1901476 ! carbohydrate transporter activity
relationship: part_of GO:0034219 ! carbohydrate transmembrane transport

[Term]
id: GO:0015145
name: monosaccharide transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a monosaccharide from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0051119 ! sugar transmembrane transporter activity
relationship: part_of GO:0015749 ! monosaccharide transport

[Term]
id: GO:0015146
name: pentose transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a pentose sugar, a monosaccharide with 5 carbon atoms, from one side of the membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0015145 ! monosaccharide transmembrane transporter activity
relationship: part_of GO:0015750 ! pentose transport

[Term]
id: GO:0015147
name: L-arabinose transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of L-arabinose from one side of the membrane to the other. Arabinose occurs free, for example in the heartwood of many conifers and in the combined states, in both furanose and pyranose forms, as a constituent of various plant hemicelluloses, bacterial polysaccharides, etc." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
subset: gosubset_prok
synonym: "L-arabinose/beta-D-thiogalactopyranoside:hydrogen antiporter activity" NARROW []
is_a: GO:0042900 ! arabinose transmembrane transporter activity

[Term]
id: GO:0015148
name: D-xylose transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of D-xylose from one side of the membrane to the other. D-xylose (the naturally occurring enantiomer is always D-) is a constituent of plant polysaccharides." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0015146 ! pentose transmembrane transporter activity
relationship: part_of GO:0015753 ! D-xylose transport

[Term]
id: GO:0015149
name: hexose transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a hexose sugar, a monosaccharide with 6 carbon atoms, from one side of a membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
xref: Reactome:REACT_102417 "Transport (efflux) of fructose, galactose, and glucose by GLUT2, Xenopus tropicalis"
xref: Reactome:REACT_103089 "Transport (efflux) of fructose, galactose, and glucose by GLUT2, Taeniopygia guttata"
xref: Reactome:REACT_109755 "Transport (efflux) of fructose, galactose, and glucose by GLUT2, Gallus gallus"
xref: Reactome:REACT_112037 "Transport (efflux) of fructose, galactose, and glucose by GLUT2, Dictyostelium discoideum"
xref: Reactome:REACT_112649 "Transport (efflux) of fructose, galactose, and glucose by GLUT2, Caenorhabditis elegans"
xref: Reactome:REACT_112973 "Transport (efflux) of fructose, galactose, and glucose by GLUT2, Arabidopsis thaliana"
xref: Reactome:REACT_113207 "Transport (efflux) of fructose, galactose, and glucose by GLUT2, Drosophila melanogaster"
xref: Reactome:REACT_114648 "Transport (efflux) of fructose, galactose, and glucose by GLUT2, Oryza sativa"
xref: Reactome:REACT_114686 "Transport (efflux) of fructose, galactose, and glucose by GLUT2, Mycobacterium tuberculosis"
xref: Reactome:REACT_115118 "Transport (efflux) of fructose, galactose, and glucose by GLUT2, Plasmodium falciparum"
xref: Reactome:REACT_28318 "Transport (efflux) of fructose, galactose, and glucose by GLUT2, Bos taurus"
xref: Reactome:REACT_87962 "Transport (efflux) of fructose, galactose, and glucose by GLUT2, Rattus norvegicus"
xref: Reactome:REACT_88880 "Transport (efflux) of fructose, galactose, and glucose by GLUT2, Canis familiaris"
xref: Reactome:REACT_9458 "Transport (efflux) of fructose, galactose, and glucose by GLUT2, Homo sapiens"
xref: Reactome:REACT_97104 "Transport (efflux) of fructose, galactose, and glucose by GLUT2, Mus musculus"
xref: Reactome:REACT_97395 "Transport (efflux) of fructose, galactose, and glucose by GLUT2, Danio rerio"
is_a: GO:0015145 ! monosaccharide transmembrane transporter activity
relationship: part_of GO:0035428 ! hexose transmembrane transport

[Term]
id: GO:0015150
name: fucose transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of fucose from one side of the membrane to the other. Fucose is 6-deoxygalactose and has two enantiomers, D-fucose and L-fucose." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0015149 ! hexose transmembrane transporter activity
relationship: part_of GO:0015756 ! fucose transport

[Term]
id: GO:0015151
name: alpha-glucoside transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of alpha-glucosides from one side of the membrane to the other. Alpha-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in an alpha configuration." [GOC:jl, GOC:mtg_transport, http://www.biochem.purdue.edu/, ISBN:0198506732, ISBN:0815340729]
is_a: GO:0042947 ! glucoside transmembrane transporter activity
relationship: part_of GO:0000017 ! alpha-glucoside transport

[Term]
id: GO:0015152
name: glucose-6-phosphate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of glucose-6-phosphate from one side of the membrane to the other. Glucose-6-phosphate is a monophosphorylated derivative of glucose with the phosphate group attached to C-6." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
xref: Reactome:REACT_11151 "alpha-D-glucose 6-phosphate [cytosol] => alpha-D-glucose 6-phosphate [endoplasmic reticulum lumen], Homo sapiens"
xref: Reactome:REACT_115666 "glucose 6-phosphate [cytosol] => glucose 6-phosphate [endoplasmic reticulum lumen], Gallus gallus"
is_a: GO:0015119 ! hexose phosphate transmembrane transporter activity
relationship: part_of GO:0015760 ! glucose-6-phosphate transport

[Term]
id: GO:0015153
name: rhamnose transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of rhamnose from one side of the membrane to the other. Rhamnose occurs commonly as a compound of plant glycosides, in polysaccharides of gums and mucilages, and in bacterial polysaccharides. It is also a component of some plant cell wall polysaccharides and frequently acts as the sugar components of flavonoids." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0015149 ! hexose transmembrane transporter activity
relationship: part_of GO:0015762 ! rhamnose transport

[Term]
id: GO:0015154
name: disaccharide transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of disaccharide from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0015157 ! oligosaccharide transmembrane transporter activity
is_a: GO:0051119 ! sugar transmembrane transporter activity
relationship: part_of GO:0015766 ! disaccharide transport

[Term]
id: GO:0015155
name: lactose transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0019189
def: "Enables the transfer of lactose from one side of the membrane to the other. Lactose is a disaccharide 4-O-beta-D-galactopyranosyl-D-glucose, and constitutes roughly 5% of the milk in almost all mammals." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
subset: gosubset_prok
synonym: "lactose permease activity" EXACT []
synonym: "lactose/glucose efflux transporter activity" NARROW []
is_a: GO:0015154 ! disaccharide transmembrane transporter activity
relationship: part_of GO:0015767 ! lactose transport

[Term]
id: GO:0015156
name: melibiose transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of melibiose from one side of the membrane to the other. Melibiose is the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose and occurs as a constituent of the trisaccharide raffinose or in the exudates and nectaries of a number of plants." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0015154 ! disaccharide transmembrane transporter activity
relationship: part_of GO:0015769 ! melibiose transport

[Term]
id: GO:0015157
name: oligosaccharide transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of oligosaccharide from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "endosomal oligosaccharide transporter" NARROW []
is_a: GO:0015144 ! carbohydrate transmembrane transporter activity
relationship: part_of GO:0015772 ! oligosaccharide transport

[Term]
id: GO:0015158
name: raffinose transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of raffinose from one side of the membrane to the other. Raffinose occurs in plants almost as commonly as sucrose and is present in cereal grains, cotton seeds, and many legumes. It is synthesized from sucrose by transfer of a galactopyranoside from myo-inositol." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
subset: gosubset_prok
synonym: "raffinose permease" RELATED []
is_a: GO:0015157 ! oligosaccharide transmembrane transporter activity
relationship: part_of GO:0015773 ! raffinose transport

[Term]
id: GO:0015159
name: polysaccharide transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of polysaccharides from one side of the membrane to the other. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [CHEBI:18154, GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0015144 ! carbohydrate transmembrane transporter activity
is_a: GO:0022884 ! macromolecule transmembrane transporter activity
relationship: part_of GO:0015774 ! polysaccharide transport

[Term]
id: GO:0015160
name: beta-glucan transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of beta-glucans from one side of the membrane to the other. Beta-glucans are compounds composed of glucose residues linked by beta-glucosidic bonds." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015159 ! polysaccharide transmembrane transporter activity
relationship: part_of GO:0015775 ! beta-glucan transport

[Term]
id: GO:0015161
name: capsular polysaccharide transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of capsular-polysaccharides from one side of the membrane to the other. Capsular polysaccharides make up the capsule, a protective structure surrounding some species of bacteria and fungi." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "capsule polysaccharide transporter activity" EXACT []
is_a: GO:0015159 ! polysaccharide transmembrane transporter activity
relationship: part_of GO:0015776 ! capsular polysaccharide transport

[Term]
id: GO:0015162
name: teichoic acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of teichoic acid from one side of the membrane to the other. Teichoic acid is any polymer occurring in the cell wall, membrane or capsule of Gram-positive bacteria and containing chains of glycerol phosphate or ribitol phosphate residues." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0022884 ! macromolecule transmembrane transporter activity
is_a: GO:1901505 ! carbohydrate derivative transporter activity

[Term]
id: GO:0015164
name: glucuronoside transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a glucuronosides from one side of the membrane to the other. Glucuronosides are any compound formed by combination of glycosidic linkage of a hydroxy compound (e.g. an alcohol or a saccharide) with the anomeric carbon atom of glucuronate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "glucuronide transporter activity" EXACT []
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity
is_a: GO:1901505 ! carbohydrate derivative transporter activity

[Term]
id: GO:0015165
name: pyrimidine nucleotide-sugar transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a pyrimidine nucleotide-sugar from one side of the membrane to the other. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0005338 ! nucleotide-sugar transmembrane transporter activity
relationship: part_of GO:0090481 ! pyrimidine nucleotide-sugar transmembrane transport

[Term]
id: GO:0015166
name: polyol transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a polyol from one side of the membrane to the other. A polyol is any polyhydric alcohol." [ISBN:0198506732]
subset: gosubset_prok
synonym: "sugar/polyol channel activity" NARROW []
xref: Reactome:REACT_105592 "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6, Xenopus tropicalis"
xref: Reactome:REACT_110900 "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6, Canis familiaris"
xref: Reactome:REACT_112673 "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6, Sus scrofa"
xref: Reactome:REACT_19299 "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6, Homo sapiens"
xref: Reactome:REACT_30102 "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6, Rattus norvegicus"
xref: Reactome:REACT_83160 "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6, Bos taurus"
xref: Reactome:REACT_84165 "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6, Gallus gallus"
xref: Reactome:REACT_85304 "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6, Danio rerio"
xref: Reactome:REACT_86539 "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6, Taeniopygia guttata"
xref: Reactome:REACT_87971 "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6, Mus musculus"
xref: Reactome:REACT_93289 "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6, Escherichia coli"
is_a: GO:0015665 ! alcohol transmembrane transporter activity
relationship: part_of GO:0015791 ! polyol transport

[Term]
id: GO:0015167
name: arabitol transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of an arabitol from one side of the membrane to the other. Arabitol is the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. The D enantiomer is present in lichens and mushrooms." [ISBN:0198506732]
synonym: "arabinitol transporter activity" EXACT []
is_a: GO:0015144 ! carbohydrate transmembrane transporter activity
is_a: GO:0015166 ! polyol transmembrane transporter activity
relationship: part_of GO:0015792 ! arabinitol transport

[Term]
id: GO:0015168
name: glycerol transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of glycerol from one side of the membrane to the other. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015144 ! carbohydrate transmembrane transporter activity
is_a: GO:0015166 ! polyol transmembrane transporter activity
relationship: part_of GO:0015793 ! glycerol transport

[Term]
id: GO:0015169
name: glycerol-3-phosphate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of glycerol-3-phosphate from one side of the membrane to the other. Glycerol-3-phosphate is a phosphoric monoester of glycerol." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015166 ! polyol transmembrane transporter activity
is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity
is_a: GO:1901505 ! carbohydrate derivative transporter activity
relationship: part_of GO:0015794 ! glycerol-3-phosphate transport

[Term]
id: GO:0015170
name: propanediol transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of propanediol from one side of the membrane to the other. Propanediol is a sweet colorless, viscous, hygroscopic liquid used as an antifreeze and in brake fluid; it is also as a humectant in cosmetics and personal care items, although it can be absorbed through the skin with harmful effects." [GOC:ai]
is_a: GO:0015166 ! polyol transmembrane transporter activity
relationship: part_of GO:0015799 ! propanediol transport

[Term]
id: GO:0015171
name: amino acid transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015359
def: "Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "amino acid permease activity" EXACT []
synonym: "amino acid transporter activity" BROAD []
synonym: "amino acid/choline transmembrane transporter activity" NARROW []
synonym: "general amino acid permease activity" RELATED []
synonym: "hydroxy/aromatic amino acid permease activity" RELATED []
xref: Reactome:REACT_100069 "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids, Oryza sativa"
xref: Reactome:REACT_100087 "L-Glutamate uptake by neurons, Danio rerio"
xref: Reactome:REACT_100156 "SLC6A6-mediated uptake of taurine and beta-alanine, Taeniopygia guttata"
xref: Reactome:REACT_100163 "SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine, Xenopus tropicalis"
xref: Reactome:REACT_100587 "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate, Xenopus tropicalis"
xref: Reactome:REACT_100649 "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids, Rattus norvegicus"
xref: Reactome:REACT_101167 "SLC16A10-mediated uptake of aromatic amino acids, Bos taurus"
xref: Reactome:REACT_101191 "SLC6A18-mediated glycine uptake, Rattus norvegicus"
xref: Reactome:REACT_101223 "SLC6A15-mediated amino acid uptake, Sus scrofa"
xref: Reactome:REACT_101433 "SLC16A10-mediated uptake of aromatic amino acids, Gallus gallus"
xref: Reactome:REACT_101624 "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine, Sus scrofa"
xref: Reactome:REACT_101649 "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine, Mus musculus"
xref: Reactome:REACT_101712 "SLC6A19-mediated uptake of neutral amino acids, Sus scrofa"
xref: Reactome:REACT_102409 "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids, Mus musculus"
xref: Reactome:REACT_102695 "SLC16A10-mediated uptake of aromatic amino acids, Xenopus tropicalis"
xref: Reactome:REACT_102832 "glutamate uptake by astrocytes, Taeniopygia guttata"
xref: Reactome:REACT_102837 "L-Glutamine transport into neurons, Arabidopsis thaliana"
xref: Reactome:REACT_103192 "SLC36A2-mediated uptake of glycine and proline, Rattus norvegicus"
xref: Reactome:REACT_103242 "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids, Taeniopygia guttata"
xref: Reactome:REACT_103345 "L-Glutamate uptake by neurons, Mus musculus"
xref: Reactome:REACT_103454 "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine, Sus scrofa"
xref: Reactome:REACT_103466 "SLC7A7 (y+LAT1)-mediated exchange of extracellular leucine for cytosolic arginine, Canis familiaris"
xref: Reactome:REACT_103638 "SLC38A1 (ATA1)-mediated uptake of neutral amino acids, Mus musculus"
xref: Reactome:REACT_103783 "SLC38A4 (ATA3)-mediated uptake of arginine and lysine, Taeniopygia guttata"
xref: Reactome:REACT_103813 "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine, Taeniopygia guttata"
xref: Reactome:REACT_103908 "L-Glutamine transport into neurons, Rattus norvegicus"
xref: Reactome:REACT_103960 "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine, Sus scrofa"
xref: Reactome:REACT_104105 "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine, Bos taurus"
xref: Reactome:REACT_104385 "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine, Xenopus tropicalis"
xref: Reactome:REACT_104394 "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine, Danio rerio"
xref: Reactome:REACT_104464 "SLC16A10-mediated uptake of aromatic amino acids, Sus scrofa"
xref: Reactome:REACT_104535 "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine, Bos taurus"
xref: Reactome:REACT_104754 "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine, Danio rerio"
xref: Reactome:REACT_104787 "glutamate uptake by astrocytes, Sus scrofa"
xref: Reactome:REACT_104927 "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine, Danio rerio"
xref: Reactome:REACT_105108 "L-Glutamine transport into neurons, Sus scrofa"
xref: Reactome:REACT_105231 "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane, Escherichia coli"
xref: Reactome:REACT_105281 "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine, Rattus norvegicus"
xref: Reactome:REACT_105363 "SLC43A1 (LAT3)-mediated uptake of large neutral amino acids, Danio rerio"
xref: Reactome:REACT_105474 "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine, Taeniopygia guttata"
xref: Reactome:REACT_105631 "SLC6A15-mediated amino acid uptake, Mus musculus"
xref: Reactome:REACT_105687 "SLC6A6-mediated uptake of taurine and beta-alanine, Mus musculus"
xref: Reactome:REACT_105911 "SLC43A1 (LAT3)-mediated uptake of large neutral amino acids, Xenopus tropicalis"
xref: Reactome:REACT_106317 "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids, Xenopus tropicalis"
xref: Reactome:REACT_106403 "SLC36A2-mediated uptake of glycine and proline, Mus musculus"
xref: Reactome:REACT_106520 "SLC7A9-mediated exchange of extracellular arginine, lysine, or cystine for cytosolic leucine, Rattus norvegicus"
xref: Reactome:REACT_106540 "L-Glutamate uptake by neurons, Bos taurus"
xref: Reactome:REACT_106600 "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine, Arabidopsis thaliana"
xref: Reactome:REACT_106760 "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine, Canis familiaris"
xref: Reactome:REACT_106787 "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids, Drosophila melanogaster"
xref: Reactome:REACT_106800 "L-Glutamate uptake by neurons, Xenopus tropicalis"
xref: Reactome:REACT_106832 "SLC36A1-mediated uptake of glycine, proline, and alanine, Gallus gallus"
xref: Reactome:REACT_107030 "SLC6A20-mediated uptake of proline, Canis familiaris"
xref: Reactome:REACT_107071 "SLC6A20-mediated uptake of proline, Gallus gallus"
xref: Reactome:REACT_107101 "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids, Bos taurus"
xref: Reactome:REACT_107194 "SLC6A18-mediated glycine uptake, Taeniopygia guttata"
xref: Reactome:REACT_107387 "L-Glutamine transport into neurons, Canis familiaris"
xref: Reactome:REACT_107542 "SLC38A4 (ATA3)-mediated uptake of arginine and lysine, Rattus norvegicus"
xref: Reactome:REACT_107574 "SLC7A8-mediated uptake of neutral amino acids, Danio rerio"
xref: Reactome:REACT_107611 "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane, Sus scrofa"
xref: Reactome:REACT_107688 "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine, Escherichia coli"
xref: Reactome:REACT_107783 "SLC6A18-mediated glycine uptake, Canis familiaris"
xref: Reactome:REACT_107867 "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine, Danio rerio"
xref: Reactome:REACT_108049 "SLC6A14-mediated uptake of basic and neutral amino acids and of beta-alanine, Bos taurus"
xref: Reactome:REACT_108162 "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine, Sus scrofa"
xref: Reactome:REACT_108166 "SLC7A10-mediated uptake of small neutral amino acids, Danio rerio"
xref: Reactome:REACT_108204 "SLC6A18-mediated glycine uptake, Drosophila melanogaster"
xref: Reactome:REACT_108496 "glutamate uptake by astrocytes, Bos taurus"
xref: Reactome:REACT_108504 "SLC6A15-mediated amino acid uptake, Danio rerio"
xref: Reactome:REACT_108529 "L-Glutamine transport into neurons, Taeniopygia guttata"
xref: Reactome:REACT_108987 "SLC7A9-mediated exchange of extracellular arginine, lysine, or cystine for cytosolic leucine, Danio rerio"
xref: Reactome:REACT_109128 "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine, Bos taurus"
xref: Reactome:REACT_109184 "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids, Mus musculus"
xref: Reactome:REACT_109453 "SLC6A18-mediated glycine uptake, Danio rerio"
xref: Reactome:REACT_109544 "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine, Gallus gallus"
xref: Reactome:REACT_109545 "SLC36A2-mediated uptake of glycine and proline, Dictyostelium discoideum"
xref: Reactome:REACT_109669 "SLC7A5-mediated uptake of neutral amino acids, Xenopus tropicalis"
xref: Reactome:REACT_109754 "SLC36A1-mediated uptake of glycine, proline, and alanine, Drosophila melanogaster"
xref: Reactome:REACT_109819 "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids, Oryza sativa"
xref: Reactome:REACT_109862 "SLC38A2 (ATA2)-mediated uptake of neutral amino acids, Xenopus tropicalis"
xref: Reactome:REACT_109871 "SLC7A5-mediated uptake of neutral amino acids, Mus musculus"
xref: Reactome:REACT_110256 "L-Glutamate uptake by neurons, Rattus norvegicus"
xref: Reactome:REACT_110364 "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine, Canis familiaris"
xref: Reactome:REACT_110465 "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids, Bos taurus"
xref: Reactome:REACT_111012 "SLC7A9-mediated exchange of extracellular arginine, lysine, or cystine for cytosolic leucine, Xenopus tropicalis"
xref: Reactome:REACT_112236 "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane, Staphylococcus aureus N315"
xref: Reactome:REACT_112274 "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids, Dictyostelium discoideum"
xref: Reactome:REACT_112402 "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine, Danio rerio"
xref: Reactome:REACT_112436 "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane, Staphylococcus aureus N315"
xref: Reactome:REACT_112482 "L-Glutamate uptake by neurons, Staphylococcus aureus N315"
xref: Reactome:REACT_112624 "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids, Mycobacterium tuberculosis"
xref: Reactome:REACT_112776 "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids, Mycobacterium tuberculosis"
xref: Reactome:REACT_112929 "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids, Dictyostelium discoideum"
xref: Reactome:REACT_112963 "L-Glutamate uptake by neurons, Caenorhabditis elegans"
xref: Reactome:REACT_113003 "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids, Staphylococcus aureus N315"
xref: Reactome:REACT_113011 "SLC7A5-mediated uptake of neutral amino acids, Drosophila melanogaster"
xref: Reactome:REACT_113174 "SLC38A4 (ATA3)-mediated uptake of arginine and lysine, Xenopus tropicalis"
xref: Reactome:REACT_113529 "SLC6A6-mediated uptake of taurine and beta-alanine, Staphylococcus aureus N315"
xref: Reactome:REACT_113690 "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids, Staphylococcus aureus N315"
xref: Reactome:REACT_113752 "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate, Caenorhabditis elegans"
xref: Reactome:REACT_113768 "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine, Staphylococcus aureus N315"
xref: Reactome:REACT_114141 "SLC6A14-mediated uptake of basic and neutral amino acids and of beta-alanine, Drosophila melanogaster"
xref: Reactome:REACT_114242 "SLC6A14-mediated uptake of basic and neutral amino acids and of beta-alanine, Danio rerio"
xref: Reactome:REACT_114291 "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine, Staphylococcus aureus N315"
xref: Reactome:REACT_114502 "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids, Mycobacterium tuberculosis"
xref: Reactome:REACT_114685 "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine, Staphylococcus aureus N315"
xref: Reactome:REACT_114768 "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids, Staphylococcus aureus N315"
xref: Reactome:REACT_114801 "SLC43A1 (LAT3)-mediated uptake of large neutral amino acids, Dictyostelium discoideum"
xref: Reactome:REACT_114819 "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids, Dictyostelium discoideum"
xref: Reactome:REACT_114980 "SLC7A9-mediated exchange of extracellular arginine, lysine, or cystine for cytosolic leucine, Sus scrofa"
xref: Reactome:REACT_115089 "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine, Staphylococcus aureus N315"
xref: Reactome:REACT_115373 "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine, Staphylococcus aureus N315"
xref: Reactome:REACT_115430 "SLC16A10-mediated uptake of aromatic amino acids, Saccharomyces cerevisiae"
xref: Reactome:REACT_13410 "SLC16A10-mediated uptake of aromatic amino acids, Homo sapiens"
xref: Reactome:REACT_13419 "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane, Homo sapiens"
xref: Reactome:REACT_13449 "SLC38A2 (ATA2)-mediated uptake of neutral amino acids, Homo sapiens"
xref: Reactome:REACT_13455 "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine, Homo sapiens"
xref: Reactome:REACT_13479 "SLC43A1 (LAT3)-mediated uptake of large neutral amino acids, Homo sapiens"
xref: Reactome:REACT_13482 "SLC7A8-mediated uptake of neutral amino acids, Homo sapiens"
xref: Reactome:REACT_13531 "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine, Homo sapiens"
xref: Reactome:REACT_13561 "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine, Homo sapiens"
xref: Reactome:REACT_13564 "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine, Homo sapiens"
xref: Reactome:REACT_13574 "L-Glutamate uptake by neurons, Homo sapiens"
xref: Reactome:REACT_13588 "glutamate uptake by astrocytes, Homo sapiens"
xref: Reactome:REACT_13590 "SLC38A1 (ATA1)-mediated uptake of neutral amino acids, Homo sapiens"
xref: Reactome:REACT_13591 "SLC6A20-mediated uptake of proline, Homo sapiens"
xref: Reactome:REACT_13593 "SLC6A15-mediated amino acid uptake, Homo sapiens"
xref: Reactome:REACT_13611 "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane, Homo sapiens"
xref: Reactome:REACT_13618 "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine, Homo sapiens"
xref: Reactome:REACT_13642 "SLC7A5-mediated uptake of neutral amino acids, Homo sapiens"
xref: Reactome:REACT_13659 "SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine, Homo sapiens"
xref: Reactome:REACT_13677 "SLC6A18-mediated glycine uptake, Homo sapiens"
xref: Reactome:REACT_13704 "SLC6A6-mediated uptake of taurine and beta-alanine, Homo sapiens"
xref: Reactome:REACT_13736 "SLC38A4 (ATA3)-mediated uptake of arginine and lysine, Homo sapiens"
xref: Reactome:REACT_13741 "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids, Homo sapiens"
xref: Reactome:REACT_13745 "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine, Homo sapiens"
xref: Reactome:REACT_13763 "L-Glutamine transport into neurons, Homo sapiens"
xref: Reactome:REACT_14785 "SLC36A1-mediated uptake of glycine, proline, and alanine, Homo sapiens"
xref: Reactome:REACT_14802 "SLC6A14-mediated uptake of basic and neutral amino acids and of beta-alanine, Homo sapiens"
xref: Reactome:REACT_14813 "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids, Homo sapiens"
xref: Reactome:REACT_14841 "SLC36A2-mediated uptake of glycine and proline, Homo sapiens"
xref: Reactome:REACT_14843 "SLC6A19-mediated uptake of neutral amino acids, Homo sapiens"
xref: Reactome:REACT_14845 "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids, Homo sapiens"
xref: Reactome:REACT_14848 "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids, Homo sapiens"
xref: Reactome:REACT_14850 "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids, Homo sapiens"
xref: Reactome:REACT_14851 "SLC7A10-mediated uptake of small neutral amino acids, Homo sapiens"
xref: Reactome:REACT_15318 "SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine, Homo sapiens"
xref: Reactome:REACT_15324 "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate, Homo sapiens"
xref: Reactome:REACT_15441 "SLC7A7 (y+LAT1)-mediated exchange of extracellular leucine for cytosolic arginine, Homo sapiens"
xref: Reactome:REACT_15542 "SLC7A9-mediated exchange of extracellular arginine, lysine, or cystine for cytosolic leucine, Homo sapiens"
xref: Reactome:REACT_23968 "Loading of GABA into clathrin sculpted GABA transport vesicle lumen, Homo sapiens"
xref: Reactome:REACT_28214 "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids, Canis familiaris"
xref: Reactome:REACT_28348 "glutamate uptake by astrocytes, Xenopus tropicalis"
xref: Reactome:REACT_28978 "SLC6A6-mediated uptake of taurine and beta-alanine, Gallus gallus"
xref: Reactome:REACT_29069 "SLC38A4 (ATA3)-mediated uptake of arginine and lysine, Arabidopsis thaliana"
xref: Reactome:REACT_29080 "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine, Rattus norvegicus"
xref: Reactome:REACT_29176 "SLC6A20-mediated uptake of proline, Rattus norvegicus"
xref: Reactome:REACT_29239 "SLC38A2 (ATA2)-mediated uptake of neutral amino acids, Sus scrofa"
xref: Reactome:REACT_29267 "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine, Canis familiaris"
xref: Reactome:REACT_29313 "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids, Mus musculus"
xref: Reactome:REACT_29576 "SLC6A14-mediated uptake of basic and neutral amino acids and of beta-alanine, Canis familiaris"
xref: Reactome:REACT_29719 "SLC7A7 (y+LAT1)-mediated exchange of extracellular leucine for cytosolic arginine, Rattus norvegicus"
xref: Reactome:REACT_29752 "SLC36A2-mediated uptake of glycine and proline, Drosophila melanogaster"
xref: Reactome:REACT_29787 "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine, Taeniopygia guttata"
xref: Reactome:REACT_29874 "SLC38A1 (ATA1)-mediated uptake of neutral amino acids, Arabidopsis thaliana"
xref: Reactome:REACT_29912 "SLC16A10-mediated uptake of aromatic amino acids, Taeniopygia guttata"
xref: Reactome:REACT_30036 "SLC38A4 (ATA3)-mediated uptake of arginine and lysine, Oryza sativa"
xref: Reactome:REACT_30139 "SLC38A2 (ATA2)-mediated uptake of neutral amino acids, Oryza sativa"
xref: Reactome:REACT_30219 "SLC38A1 (ATA1)-mediated uptake of neutral amino acids, Sus scrofa"
xref: Reactome:REACT_30264 "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate, Canis familiaris"
xref: Reactome:REACT_30326 "SLC6A19-mediated uptake of neutral amino acids, Mus musculus"
xref: Reactome:REACT_30352 "SLC7A9-mediated exchange of extracellular arginine, lysine, or cystine for cytosolic leucine, Mus musculus"
xref: Reactome:REACT_30518 "SLC6A19-mediated uptake of neutral amino acids, Xenopus tropicalis"
xref: Reactome:REACT_30598 "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine, Rattus norvegicus"
xref: Reactome:REACT_30817 "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane, Danio rerio"
xref: Reactome:REACT_30829 "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids, Rattus norvegicus"
xref: Reactome:REACT_30832 "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids, Sus scrofa"
xref: Reactome:REACT_30847 "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids, Rattus norvegicus"
xref: Reactome:REACT_30869 "SLC38A4 (ATA3)-mediated uptake of arginine and lysine, Danio rerio"
xref: Reactome:REACT_30917 "SLC38A1 (ATA1)-mediated uptake of neutral amino acids, Bos taurus"
xref: Reactome:REACT_31023 "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids, Canis familiaris"
xref: Reactome:REACT_31132 "SLC38A2 (ATA2)-mediated uptake of neutral amino acids, Gallus gallus"
xref: Reactome:REACT_31163 "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids, Bos taurus"
xref: Reactome:REACT_31487 "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine, Mus musculus"
xref: Reactome:REACT_31616 "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids, Gallus gallus"
xref: Reactome:REACT_31815 "SLC38A2 (ATA2)-mediated uptake of neutral amino acids, Mus musculus"
xref: Reactome:REACT_31829 "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine, Canis familiaris"
xref: Reactome:REACT_31903 "SLC43A1 (LAT3)-mediated uptake of large neutral amino acids, Canis familiaris"
xref: Reactome:REACT_31986 "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine, Xenopus tropicalis"
xref: Reactome:REACT_32051 "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane, Rattus norvegicus"
xref: Reactome:REACT_32114 "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids, Taeniopygia guttata"
xref: Reactome:REACT_32389 "SLC6A15-mediated amino acid uptake, Bos taurus"
xref: Reactome:REACT_32475 "glutamate uptake by astrocytes, Gallus gallus"
xref: Reactome:REACT_32609 "SLC6A6-mediated uptake of taurine and beta-alanine, Sus scrofa"
xref: Reactome:REACT_32701 "L-Glutamine transport into neurons, Oryza sativa"
xref: Reactome:REACT_32856 "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine, Rattus norvegicus"
xref: Reactome:REACT_32879 "SLC36A1-mediated uptake of glycine, proline, and alanine, Dictyostelium discoideum"
xref: Reactome:REACT_32881 "SLC6A14-mediated uptake of basic and neutral amino acids and of beta-alanine, Gallus gallus"
xref: Reactome:REACT_33143 "SLC43A1 (LAT3)-mediated uptake of large neutral amino acids, Rattus norvegicus"
xref: Reactome:REACT_33918 "SLC7A8-mediated uptake of neutral amino acids, Xenopus tropicalis"
xref: Reactome:REACT_34079 "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids, Mus musculus"
xref: Reactome:REACT_34240 "SLC7A7 (y+LAT1)-mediated exchange of extracellular leucine for cytosolic arginine, Bos taurus"
xref: Reactome:REACT_34356 "SLC7A9-mediated exchange of extracellular arginine, lysine, or cystine for cytosolic leucine, Taeniopygia guttata"
xref: Reactome:REACT_34360 "SLC6A20-mediated uptake of proline, Mus musculus"
xref: Reactome:REACT_34431 "L-Glutamate uptake by neurons, Taeniopygia guttata"
xref: Reactome:REACT_34579 "SLC7A8-mediated uptake of neutral amino acids, Rattus norvegicus"
xref: Reactome:REACT_34616 "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids, Gallus gallus"
xref: Reactome:REACT_34653 "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine, Canis familiaris"
xref: Reactome:REACT_34759 "SLC6A19-mediated uptake of neutral amino acids, Danio rerio"
xref: Reactome:REACT_34779 "SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine, Canis familiaris"
xref: Reactome:REACT_34803 "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane, Mus musculus"
xref: Reactome:REACT_35907 "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine, Canis familiaris"
xref: Reactome:REACT_77117 "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids, Bos taurus"
xref: Reactome:REACT_77825 "SLC36A1-mediated uptake of glycine, proline, and alanine, Canis familiaris"
xref: Reactome:REACT_77848 "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine, Gallus gallus"
xref: Reactome:REACT_77862 "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids, Danio rerio"
xref: Reactome:REACT_77893 "SLC7A5-mediated uptake of neutral amino acids, Danio rerio"
xref: Reactome:REACT_78528 "SLC6A18-mediated glycine uptake, Sus scrofa"
xref: Reactome:REACT_78570 "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids, Danio rerio"
xref: Reactome:REACT_78600 "SLC38A1 (ATA1)-mediated uptake of neutral amino acids, Canis familiaris"
xref: Reactome:REACT_78882 "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids, Drosophila melanogaster"
xref: Reactome:REACT_78914 "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids, Canis familiaris"
xref: Reactome:REACT_79005 "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine, Xenopus tropicalis"
xref: Reactome:REACT_79080 "SLC38A2 (ATA2)-mediated uptake of neutral amino acids, Taeniopygia guttata"
xref: Reactome:REACT_79116 "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids, Xenopus tropicalis"
xref: Reactome:REACT_79231 "SLC7A7 (y+LAT1)-mediated exchange of extracellular leucine for cytosolic arginine, Xenopus tropicalis"
xref: Reactome:REACT_79484 "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine, Taeniopygia guttata"
xref: Reactome:REACT_79529 "SLC6A14-mediated uptake of basic and neutral amino acids and of beta-alanine, Taeniopygia guttata"
xref: Reactome:REACT_80154 "glutamate uptake by astrocytes, Canis familiaris"
xref: Reactome:REACT_80220 "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine, Gallus gallus"
xref: Reactome:REACT_80313 "L-Glutamine transport into neurons, Mus musculus"
xref: Reactome:REACT_80467 "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine, Bos taurus"
xref: Reactome:REACT_80682 "SLC7A8-mediated uptake of neutral amino acids, Mus musculus"
xref: Reactome:REACT_80759 "SLC38A2 (ATA2)-mediated uptake of neutral amino acids, Danio rerio"
xref: Reactome:REACT_80767 "SLC36A2-mediated uptake of glycine and proline, Canis familiaris"
xref: Reactome:REACT_80898 "SLC7A10-mediated uptake of small neutral amino acids, Drosophila melanogaster"
xref: Reactome:REACT_80915 "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine, Bos taurus"
xref: Reactome:REACT_81061 "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids, Xenopus tropicalis"
xref: Reactome:REACT_81115 "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids, Oryza sativa"
xref: Reactome:REACT_81163 "SLC16A10-mediated uptake of aromatic amino acids, Canis familiaris"
xref: Reactome:REACT_81172 "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids, Bos taurus"
xref: Reactome:REACT_81320 "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane, Xenopus tropicalis"
xref: Reactome:REACT_81324 "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids, Danio rerio"
xref: Reactome:REACT_81374 "SLC7A9-mediated exchange of extracellular arginine, lysine, or cystine for cytosolic leucine, Drosophila melanogaster"
xref: Reactome:REACT_81495 "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids, Gallus gallus"
xref: Reactome:REACT_81689 "SLC6A19-mediated uptake of neutral amino acids, Drosophila melanogaster"
xref: Reactome:REACT_81760 "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids, Canis familiaris"
xref: Reactome:REACT_82002 "SLC38A1 (ATA1)-mediated uptake of neutral amino acids, Rattus norvegicus"
xref: Reactome:REACT_82027 "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids, Drosophila melanogaster"
xref: Reactome:REACT_82091 "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane, Bos taurus"
xref: Reactome:REACT_82326 "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine, Rattus norvegicus"
xref: Reactome:REACT_82518 "SLC7A9-mediated exchange of extracellular arginine, lysine, or cystine for cytosolic leucine, Gallus gallus"
xref: Reactome:REACT_82571 "L-Glutamate uptake by neurons, Canis familiaris"
xref: Reactome:REACT_82615 "SLC36A2-mediated uptake of glycine and proline, Xenopus tropicalis"
xref: Reactome:REACT_82810 "SLC6A6-mediated uptake of taurine and beta-alanine, Xenopus tropicalis"
xref: Reactome:REACT_82891 "SLC6A15-mediated amino acid uptake, Xenopus tropicalis"
xref: Reactome:REACT_83020 "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine, Taeniopygia guttata"
xref: Reactome:REACT_83240 "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine, Xenopus tropicalis"
xref: Reactome:REACT_83259 "SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine, Mus musculus"
xref: Reactome:REACT_83512 "SLC36A2-mediated uptake of glycine and proline, Sus scrofa"
xref: Reactome:REACT_83514 "SLC6A15-mediated amino acid uptake, Taeniopygia guttata"
xref: Reactome:REACT_83732 "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine, Mus musculus"
xref: Reactome:REACT_83774 "SLC36A2-mediated uptake of glycine and proline, Bos taurus"
xref: Reactome:REACT_84031 "SLC6A6-mediated uptake of taurine and beta-alanine, Rattus norvegicus"
xref: Reactome:REACT_84342 "SLC6A20-mediated uptake of proline, Drosophila melanogaster"
xref: Reactome:REACT_84398 "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine, Mus musculus"
xref: Reactome:REACT_84457 "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine, Gallus gallus"
xref: Reactome:REACT_84721 "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine, Sus scrofa"
xref: Reactome:REACT_84777 "L-Glutamate uptake by neurons, Gallus gallus"
xref: Reactome:REACT_84892 "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids, Danio rerio"
xref: Reactome:REACT_84982 "SLC38A1 (ATA1)-mediated uptake of neutral amino acids, Oryza sativa"
xref: Reactome:REACT_85083 "SLC7A7 (y+LAT1)-mediated exchange of extracellular leucine for cytosolic arginine, Danio rerio"
xref: Reactome:REACT_85113 "SLC36A1-mediated uptake of glycine, proline, and alanine, Danio rerio"
xref: Reactome:REACT_85124 "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids, Canis familiaris"
xref: Reactome:REACT_85205 "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids, Xenopus tropicalis"
xref: Reactome:REACT_85235 "SLC7A9-mediated exchange of extracellular arginine, lysine, or cystine for cytosolic leucine, Canis familiaris"
xref: Reactome:REACT_85417 "L-Glutamine transport into neurons, Gallus gallus"
xref: Reactome:REACT_85981 "SLC16A10-mediated uptake of aromatic amino acids, Drosophila melanogaster"
xref: Reactome:REACT_85998 "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids, Rattus norvegicus"
xref: Reactome:REACT_86102 "SLC6A18-mediated glycine uptake, Gallus gallus"
xref: Reactome:REACT_86103 "SLC36A1-mediated uptake of glycine, proline, and alanine, Caenorhabditis elegans"
xref: Reactome:REACT_86124 "SLC36A2-mediated uptake of glycine and proline, Taeniopygia guttata"
xref: Reactome:REACT_86218 "SLC7A5-mediated uptake of neutral amino acids, Rattus norvegicus"
xref: Reactome:REACT_86425 "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine, Xenopus tropicalis"
xref: Reactome:REACT_86444 "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine, Xenopus tropicalis"
xref: Reactome:REACT_86475 "L-Glutamate uptake by neurons, Sus scrofa"
xref: Reactome:REACT_86503 "SLC38A4 (ATA3)-mediated uptake of arginine and lysine, Mus musculus"
xref: Reactome:REACT_86528 "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine, Escherichia coli"
xref: Reactome:REACT_86639 "glutamate uptake by astrocytes, Mus musculus"
xref: Reactome:REACT_87060 "SLC36A1-mediated uptake of glycine, proline, and alanine, Rattus norvegicus"
xref: Reactome:REACT_87072 "SLC36A1-mediated uptake of glycine, proline, and alanine, Bos taurus"
xref: Reactome:REACT_87250 "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids, Arabidopsis thaliana"
xref: Reactome:REACT_87256 "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine, Mus musculus"
xref: Reactome:REACT_87500 "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids, Sus scrofa"
xref: Reactome:REACT_87614 "SLC36A2-mediated uptake of glycine and proline, Caenorhabditis elegans"
xref: Reactome:REACT_87654 "SLC36A2-mediated uptake of glycine and proline, Danio rerio"
xref: Reactome:REACT_87692 "SLC16A10-mediated uptake of aromatic amino acids, Rattus norvegicus"
xref: Reactome:REACT_87702 "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane, Danio rerio"
xref: Reactome:REACT_87762 "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids, Arabidopsis thaliana"
xref: Reactome:REACT_88028 "SLC7A8-mediated uptake of neutral amino acids, Canis familiaris"
xref: Reactome:REACT_88285 "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids, Sus scrofa"
xref: Reactome:REACT_88308 "SLC7A8-mediated uptake of neutral amino acids, Bos taurus"
xref: Reactome:REACT_88447 "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids, Danio rerio"
xref: Reactome:REACT_88831 "SLC7A5-mediated uptake of neutral amino acids, Bos taurus"
xref: Reactome:REACT_88907 "SLC38A4 (ATA3)-mediated uptake of arginine and lysine, Bos taurus"
xref: Reactome:REACT_89043 "SLC6A6-mediated uptake of taurine and beta-alanine, Danio rerio"
xref: Reactome:REACT_89087 "SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine, Bos taurus"
xref: Reactome:REACT_89143 "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane, Xenopus tropicalis"
xref: Reactome:REACT_89181 "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids, Taeniopygia guttata"
xref: Reactome:REACT_89479 "SLC38A4 (ATA3)-mediated uptake of arginine and lysine, Canis familiaris"
xref: Reactome:REACT_89514 "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids, Arabidopsis thaliana"
xref: Reactome:REACT_89662 "L-Glutamine transport into neurons, Xenopus tropicalis"
xref: Reactome:REACT_89684 "SLC43A1 (LAT3)-mediated uptake of large neutral amino acids, Mus musculus"
xref: Reactome:REACT_89787 "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate, Bos taurus"
xref: Reactome:REACT_89825 "SLC6A6-mediated uptake of taurine and beta-alanine, Canis familiaris"
xref: Reactome:REACT_90091 "SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine, Rattus norvegicus"
xref: Reactome:REACT_90489 "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine, Gallus gallus"
xref: Reactome:REACT_90863 "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids, Gallus gallus"
xref: Reactome:REACT_91122 "SLC6A18-mediated glycine uptake, Bos taurus"
xref: Reactome:REACT_91495 "SLC7A10-mediated uptake of small neutral amino acids, Mus musculus"
xref: Reactome:REACT_91677 "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane, Bos taurus"
xref: Reactome:REACT_91835 "SLC7A9-mediated exchange of extracellular arginine, lysine, or cystine for cytosolic leucine, Bos taurus"
xref: Reactome:REACT_91869 "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane, Escherichia coli"
xref: Reactome:REACT_91888 "SLC38A1 (ATA1)-mediated uptake of neutral amino acids, Gallus gallus"
xref: Reactome:REACT_91929 "SLC7A8-mediated uptake of neutral amino acids, Drosophila melanogaster"
xref: Reactome:REACT_92049 "glutamate uptake by astrocytes, Danio rerio"
xref: Reactome:REACT_92325 "SLC7A7 (y+LAT1)-mediated exchange of extracellular leucine for cytosolic arginine, Mus musculus"
xref: Reactome:REACT_92633 "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine, Escherichia coli"
xref: Reactome:REACT_92666 "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate, Rattus norvegicus"
xref: Reactome:REACT_92761 "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids, Rattus norvegicus"
xref: Reactome:REACT_93036 "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane, Mus musculus"
xref: Reactome:REACT_93146 "SLC16A10-mediated uptake of aromatic amino acids, Mus musculus"
xref: Reactome:REACT_93208 "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine, Sus scrofa"
xref: Reactome:REACT_93397 "SLC36A1-mediated uptake of glycine, proline, and alanine, Sus scrofa"
xref: Reactome:REACT_93424 "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane, Rattus norvegicus"
xref: Reactome:REACT_93743 "SLC6A19-mediated uptake of neutral amino acids, Taeniopygia guttata"
xref: Reactome:REACT_94218 "SLC38A1 (ATA1)-mediated uptake of neutral amino acids, Taeniopygia guttata"
xref: Reactome:REACT_94508 "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids, Xenopus tropicalis"
xref: Reactome:REACT_94554 "SLC36A1-mediated uptake of glycine, proline, and alanine, Taeniopygia guttata"
xref: Reactome:REACT_94696 "SLC38A4 (ATA3)-mediated uptake of arginine and lysine, Gallus gallus"
xref: Reactome:REACT_94719 "SLC38A2 (ATA2)-mediated uptake of neutral amino acids, Bos taurus"
xref: Reactome:REACT_94811 "L-Glutamine transport into neurons, Danio rerio"
xref: Reactome:REACT_94819 "SLC36A1-mediated uptake of glycine, proline, and alanine, Mus musculus"
xref: Reactome:REACT_94936 "SLC38A2 (ATA2)-mediated uptake of neutral amino acids, Canis familiaris"
xref: Reactome:REACT_94990 "SLC6A14-mediated uptake of basic and neutral amino acids and of beta-alanine, Mus musculus"
xref: Reactome:REACT_95263 "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane, Canis familiaris"
xref: Reactome:REACT_95439 "SLC6A14-mediated uptake of basic and neutral amino acids and of beta-alanine, Rattus norvegicus"
xref: Reactome:REACT_95505 "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine, Rattus norvegicus"
xref: Reactome:REACT_95807 "glutamate uptake by astrocytes, Rattus norvegicus"
xref: Reactome:REACT_96028 "SLC6A19-mediated uptake of neutral amino acids, Gallus gallus"
xref: Reactome:REACT_96064 "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids, Mus musculus"
xref: Reactome:REACT_96161 "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids, Taeniopygia guttata"
xref: Reactome:REACT_96681 "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate, Danio rerio"
xref: Reactome:REACT_96824 "SLC6A15-mediated amino acid uptake, Canis familiaris"
xref: Reactome:REACT_96837 "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine, Danio rerio"
xref: Reactome:REACT_96872 "SLC7A10-mediated uptake of small neutral amino acids, Xenopus tropicalis"
xref: Reactome:REACT_96955 "L-Glutamate uptake by neurons, Escherichia coli"
xref: Reactome:REACT_96958 "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine, Oryza sativa"
xref: Reactome:REACT_96961 "SLC38A2 (ATA2)-mediated uptake of neutral amino acids, Arabidopsis thaliana"
xref: Reactome:REACT_97078 "SLC7A10-mediated uptake of small neutral amino acids, Rattus norvegicus"
xref: Reactome:REACT_97150 "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate, Mus musculus"
xref: Reactome:REACT_97229 "SLC6A19-mediated uptake of neutral amino acids, Rattus norvegicus"
xref: Reactome:REACT_97314 "SLC6A15-mediated amino acid uptake, Rattus norvegicus"
xref: Reactome:REACT_97371 "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids, Gallus gallus"
xref: Reactome:REACT_97431 "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine, Escherichia coli"
xref: Reactome:REACT_97614 "SLC36A1-mediated uptake of glycine, proline, and alanine, Xenopus tropicalis"
xref: Reactome:REACT_97775 "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane, Canis familiaris"
xref: Reactome:REACT_98209 "L-Glutamine transport into neurons, Bos taurus"
xref: Reactome:REACT_98437 "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine, Bos taurus"
xref: Reactome:REACT_98442 "SLC6A15-mediated amino acid uptake, Gallus gallus"
xref: Reactome:REACT_98455 "SLC7A5-mediated uptake of neutral amino acids, Canis familiaris"
xref: Reactome:REACT_98527 "SLC6A20-mediated uptake of proline, Bos taurus"
xref: Reactome:REACT_98630 "SLC6A19-mediated uptake of neutral amino acids, Canis familiaris"
xref: Reactome:REACT_98706 "SLC6A14-mediated uptake of basic and neutral amino acids and of beta-alanine, Xenopus tropicalis"
xref: Reactome:REACT_98712 "SLC6A20-mediated uptake of proline, Taeniopygia guttata"
xref: Reactome:REACT_98995 "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane, Sus scrofa"
xref: Reactome:REACT_99008 "SLC6A6-mediated uptake of taurine and beta-alanine, Bos taurus"
xref: Reactome:REACT_99040 "SLC6A18-mediated glycine uptake, Mus musculus"
xref: Reactome:REACT_99165 "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids, Taeniopygia guttata"
xref: Reactome:REACT_99247 "SLC16A10-mediated uptake of aromatic amino acids, Danio rerio"
xref: Reactome:REACT_99682 "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine, Mus musculus"
xref: Reactome:REACT_99696 "SLC7A10-mediated uptake of small neutral amino acids, Canis familiaris"
xref: Reactome:REACT_99822 "SLC38A2 (ATA2)-mediated uptake of neutral amino acids, Rattus norvegicus"
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity
relationship: part_of GO:0003333 ! amino acid transmembrane transport

[Term]
id: GO:0015172
name: acidic amino acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of acidic amino acids from one side of a membrane to the other. Acidic amino acids have a pH below 7." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "acidic amino acid transporter activity" BROAD []
xref: Reactome:REACT_103758 "aspartate [mitochondrial matrix] + glutamate [cytosol] => aspartate [cytosol] + glutamate [mitochondrial matrix], Sus scrofa"
xref: Reactome:REACT_115621 "aspartate [mitochondrial matrix] + glutamate [cytosol] <=> aspartate [cytosol] + glutamate [mitochondrial matrix], Gallus gallus"
xref: Reactome:REACT_14830 "aspartate [mitochondrial matrix] + glutamate [cytosol] => aspartate [cytosol] + glutamate [mitochondrial matrix], Homo sapiens"
xref: Reactome:REACT_29921 "aspartate [mitochondrial matrix] + glutamate [cytosol] => aspartate [cytosol] + glutamate [mitochondrial matrix], Gallus gallus"
xref: Reactome:REACT_32110 "aspartate [mitochondrial matrix] + glutamate [cytosol] => aspartate [cytosol] + glutamate [mitochondrial matrix], Danio rerio"
xref: Reactome:REACT_33131 "aspartate [mitochondrial matrix] + glutamate [cytosol] => aspartate [cytosol] + glutamate [mitochondrial matrix], Dictyostelium discoideum"
xref: Reactome:REACT_38755 "aspartate [mitochondrial matrix] + glutamate [cytosol] => aspartate [cytosol] + glutamate [mitochondrial matrix], Rattus norvegicus"
xref: Reactome:REACT_78019 "aspartate [mitochondrial matrix] + glutamate [cytosol] => aspartate [cytosol] + glutamate [mitochondrial matrix], Caenorhabditis elegans"
xref: Reactome:REACT_81291 "aspartate [mitochondrial matrix] + glutamate [cytosol] => aspartate [cytosol] + glutamate [mitochondrial matrix], Canis familiaris"
xref: Reactome:REACT_82144 "aspartate [mitochondrial matrix] + glutamate [cytosol] => aspartate [cytosol] + glutamate [mitochondrial matrix], Drosophila melanogaster"
xref: Reactome:REACT_82641 "aspartate [mitochondrial matrix] + glutamate [cytosol] => aspartate [cytosol] + glutamate [mitochondrial matrix], Mus musculus"
xref: Reactome:REACT_83233 "aspartate [mitochondrial matrix] + glutamate [cytosol] => aspartate [cytosol] + glutamate [mitochondrial matrix], Saccharomyces cerevisiae"
xref: Reactome:REACT_85817 "aspartate [mitochondrial matrix] + glutamate [cytosol] => aspartate [cytosol] + glutamate [mitochondrial matrix], Xenopus tropicalis"
xref: Reactome:REACT_86926 "aspartate [mitochondrial matrix] + glutamate [cytosol] => aspartate [cytosol] + glutamate [mitochondrial matrix], Bos taurus"
xref: Reactome:REACT_99728 "aspartate [mitochondrial matrix] + glutamate [cytosol] => aspartate [cytosol] + glutamate [mitochondrial matrix], Taeniopygia guttata"
is_a: GO:0015171 ! amino acid transmembrane transporter activity
relationship: part_of GO:0015800 ! acidic amino acid transport

[Term]
id: GO:0015173
name: aromatic amino acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of aromatic amino acids from one side of a membrane to the other. Aromatic amino acids have an aromatic ring." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "aromatic amino acid transporter activity" BROAD []
synonym: "hydroxy/aromatic amino acid permease activity" RELATED []
synonym: "valine/tyrosine/tryptophan permease activity" RELATED []
is_a: GO:0015171 ! amino acid transmembrane transporter activity
relationship: part_of GO:0015801 ! aromatic amino acid transport

[Term]
id: GO:0015174
name: basic amino acid transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0005286
alt_id: GO:0015326
def: "Catalysis of the transfer of basic amino acids from one side of a membrane to the other. Basic amino acids have a pH above 7." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "basic amino acid permease activity" EXACT []
synonym: "basic amino acid transporter activity" BROAD []
synonym: "cationic amino acid transmembrane transporter activity" RELATED []
is_a: GO:0015171 ! amino acid transmembrane transporter activity
relationship: part_of GO:1990822 ! basic amino acid transmembrane transport

[Term]
id: GO:0015175
name: neutral amino acid transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of neutral amino acids from one side of a membrane to the other. Neutral amino acids have a pH of 7." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "neutral amino acid transporter activity" BROAD []
is_a: GO:0015171 ! amino acid transmembrane transporter activity
relationship: part_of GO:0015804 ! neutral amino acid transport

[Term]
id: GO:0015176
name: obsolete holin
namespace: molecular_function
def: "OBSOLETE. Primary function of holins appears to be transport of murein hydrolases across the cytoplasmic membrane to the cell wall of bacteria, where these enzymes hydrolyze the cell wall polymer as a prelude to cell lysis. When chromosomally encoded, these enzymes are therefore autolysins. Holins may also facilitate leakage of electrolytes and nutrients from the cell cytoplasm, thereby promoting cell death. Some catalyze export of nucleases." [TC:1.A.38.-.-]
comment: This term was made obsolete because it represents a class of gene products.
synonym: "holin" EXACT []
is_obsolete: true
consider: GO:0008565
consider: GO:0019835

[Term]
id: GO:0015179
name: L-amino acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "L-amino acid transporter activity" BROAD []
xref: Reactome:REACT_13773 "Glutamine transport from astrocytes, Homo sapiens"
xref: Reactome:REACT_29246 "Glutamine transport from astrocytes, Taeniopygia guttata"
xref: Reactome:REACT_33865 "Glutamine transport from astrocytes, Oryza sativa"
xref: Reactome:REACT_77585 "Glutamine transport from astrocytes, Rattus norvegicus"
xref: Reactome:REACT_78488 "Glutamine transport from astrocytes, Arabidopsis thaliana"
xref: Reactome:REACT_83491 "Glutamine transport from astrocytes, Mus musculus"
xref: Reactome:REACT_87080 "Glutamine transport from astrocytes, Gallus gallus"
xref: Reactome:REACT_88370 "Glutamine transport from astrocytes, Canis familiaris"
xref: Reactome:REACT_93418 "Glutamine transport from astrocytes, Sus scrofa"
xref: Reactome:REACT_93773 "Glutamine transport from astrocytes, Bos taurus"
is_a: GO:0015171 ! amino acid transmembrane transporter activity
relationship: part_of GO:0015807 ! L-amino acid transport
relationship: part_of GO:1902475 ! L-alpha-amino acid transmembrane transport

[Term]
id: GO:0015180
name: L-alanine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of L-alanine from one side of a membrane to the other. L-alanine is the L-enantiomer of 2-aminopropanoic acid." [GOC:go_curators, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
subset: gosubset_prok
synonym: "L-alanine transporter activity" BROAD []
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity
is_a: GO:0022858 ! alanine transmembrane transporter activity
relationship: part_of GO:0015808 ! L-alanine transport

[Term]
id: GO:0015181
name: arginine transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0005288
def: "Enables the stereospecific transfer of arginine, 2-amino-5-guanidinopentanoic acid, across a biological membrane." [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
subset: gosubset_prok
synonym: "arginine permease activity" EXACT []
synonym: "histidine/arginine/lysine/ornithine porter activity" NARROW []
synonym: "L-arginine transporter activity" NARROW []
xref: RHEA:32146
is_a: GO:0008324 ! cation transmembrane transporter activity
is_a: GO:0015174 ! basic amino acid transmembrane transporter activity
relationship: part_of GO:1903826 ! arginine transmembrane transport

[Term]
id: GO:0015182
name: L-asparagine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of L-asparagine from one side of a membrane to the other. L-asparagine is the L-enantiomer of alpha-aminosuccinamic acid." [GOC:go_curators, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
subset: gosubset_prok
synonym: "asparagine/glutamine permease activity" NARROW []
synonym: "L-asparagine transporter activity" BROAD []
is_a: GO:0008324 ! cation transmembrane transporter activity
is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity
is_a: GO:0042887 ! amide transmembrane transporter activity
relationship: part_of GO:0006867 ! asparagine transport

[Term]
id: GO:0015183
name: L-aspartate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of L-aspartate from one side of a membrane to the other. L-aspartate is the anion derived from aspartic acid." [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
subset: gosubset_prok
synonym: "glutamate/aspartate porter activity" NARROW []
synonym: "glutamate/aspartate:sodium symporter activity" NARROW []
synonym: "L-aspartate transporter activity" BROAD []
is_a: GO:0015172 ! acidic amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity
is_a: GO:0015556 ! C4-dicarboxylate transmembrane transporter activity
relationship: part_of GO:0089712 ! L-aspartate transmembrane transport

[Term]
id: GO:0015184
name: L-cystine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of L-cystine from one side of a membrane to the other." [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
synonym: "cystine/diaminopimelate porter activity" NARROW []
synonym: "L-cystine transporter activity" BROAD []
is_a: GO:0000099 ! sulfur amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity
is_a: GO:0072349 ! modified amino acid transmembrane transporter activity
relationship: part_of GO:0015811 ! L-cystine transport

[Term]
id: GO:0015185
name: gamma-aminobutyric acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of gamma-aminobutyric acid from one side of a membrane to the other. Gamma-aminobutyric acid is 4-aminobutyrate (GABA)." [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
subset: gosubset_prok
synonym: "4-aminobutanoate transporter activity" EXACT []
synonym: "4-aminobutyrate transporter activity" EXACT []
synonym: "betaine/GABA:sodium symporter activity" NARROW []
synonym: "GABA transporter activity" EXACT []
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:0015171 ! amino acid transmembrane transporter activity
relationship: part_of GO:0015812 ! gamma-aminobutyric acid transport

[Term]
id: GO:0015186
name: L-glutamine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of L-glutamine from one side of a membrane to the other. L-glutamine is 2-amino-4-carbamoylbutanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "asparagine/glutamine permease activity" NARROW []
is_a: GO:0008324 ! cation transmembrane transporter activity
is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity
relationship: part_of GO:0006868 ! glutamine transport

[Term]
id: GO:0015187
name: glycine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of glycine from one side of a membrane to the other. Glycine is aminoethanoic acid." [GOC:ai]
subset: gosubset_prok
synonym: "glycine betaine/proline porter activity" NARROW []
synonym: "glycine transporter activity" BROAD []
synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" NARROW []
is_a: GO:0008324 ! cation transmembrane transporter activity
is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity
relationship: part_of GO:0015816 ! glycine transport

[Term]
id: GO:0015188
name: L-isoleucine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of L-isoleucine from one side of a membrane to the other. L-isoleucine is (2R*,3R*)-2-amino-3-methylpentanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "isoleucine/valine:sodium symporter activity" NARROW []
synonym: "L-isoleucine transporter activity" BROAD []
synonym: "leucine/isoleucine/valine porter activity" NARROW []
synonym: "leucine/valine/isoleucine permease activity" NARROW []
is_a: GO:0008324 ! cation transmembrane transporter activity
is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity
is_a: GO:0015658 ! branched-chain amino acid transmembrane transporter activity

[Term]
id: GO:0015189
name: L-lysine transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0005293
def: "Enables the transfer of L-lysine from one side of a membrane to the other. L-lysine is 2,6-diaminohexanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "histidine/arginine/lysine/ornithine porter activity" NARROW []
synonym: "L-lysine permease" RELATED []
synonym: "lysine permease activity" RELATED []
is_a: GO:0008324 ! cation transmembrane transporter activity
is_a: GO:0015174 ! basic amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity
relationship: part_of GO:1903401 ! L-lysine transmembrane transport

[Term]
id: GO:0015190
name: L-leucine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of L-leucine from one side of a membrane to the other. L-leucine is 2-amino-4-methylpentanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "L-leucine transporter activity" BROAD []
synonym: "leucine/isoleucine/valine porter activity" NARROW []
synonym: "leucine/valine/isoleucine permease activity" NARROW []
is_a: GO:0008324 ! cation transmembrane transporter activity
is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity
is_a: GO:0015658 ! branched-chain amino acid transmembrane transporter activity

[Term]
id: GO:0015191
name: L-methionine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of L-methionine from one side of a membrane to the other. L-methionine is 2-amino-4-(methylthio)butanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "L-methionine transporter activity" BROAD []
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity
is_a: GO:0043865 ! methionine transmembrane transporter activity

[Term]
id: GO:0015192
name: L-phenylalanine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of L-phenylalanine from one side of a membrane to the other. L-phenylalanine is 2-amino-3-phenylpropanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "L-phenylalanine permease activity" EXACT []
synonym: "L-phenylalanine transporter activity" BROAD []
is_a: GO:0008324 ! cation transmembrane transporter activity
is_a: GO:0015173 ! aromatic amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity
relationship: part_of GO:0015823 ! phenylalanine transport

[Term]
id: GO:0015193
name: L-proline transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0005296
def: "Enables the transfer of L-proline from one side of a membrane to the other. L-proline is pyrrolidine-2-carboxylic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "glycine betaine/proline porter activity" NARROW []
synonym: "L-proline permease activity" RELATED []
synonym: "L-proline transporter activity" BROAD []
synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" NARROW []
is_a: GO:0008324 ! cation transmembrane transporter activity
is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity
relationship: part_of GO:0035524 ! proline transmembrane transport

[Term]
id: GO:0015194
name: L-serine transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015511
def: "Enables the transfer of L-serine from one side of a membrane to the other. L-serine is the L-enantiomer of 2-amino-3-hydroxypropanoic acid." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "L-serine permease activity" RELATED []
synonym: "L-serine transporter activity" BROAD []
synonym: "serine transporter activity" BROAD []
synonym: "threonine/serine:sodium symporter activity" RELATED []
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity
is_a: GO:0022889 ! serine transmembrane transporter activity
relationship: part_of GO:0015825 ! L-serine transport

[Term]
id: GO:0015195
name: L-threonine transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015512
def: "Enables the transfer of L-threonine from one side of a membrane to the other. L-threonine is (2R*,3S*)-2-amino-3-hydroxybutanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "L-threonine permease activity" RELATED []
synonym: "L-threonine transporter activity" BROAD []
synonym: "threonine/serine:sodium symporter activity" RELATED []
is_a: GO:0008324 ! cation transmembrane transporter activity
is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity
relationship: part_of GO:0015826 ! threonine transport

[Term]
id: GO:0015196
name: L-tryptophan transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0005299
def: "Enables the transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "L-tryptophan permease activity" EXACT []
synonym: "L-tryptophan transporter activity" BROAD []
synonym: "valine/tyrosine/tryptophan permease activity" NARROW []
is_a: GO:0008324 ! cation transmembrane transporter activity
is_a: GO:0015173 ! aromatic amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity
relationship: part_of GO:0015827 ! tryptophan transport

[Term]
id: GO:0015197
name: peptide transporter activity
namespace: molecular_function
alt_id: GO:0015637
def: "Enables the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells." [GOC:ai]
subset: gosubset_prok
synonym: "peptide uptake permease activity" RELATED []
is_a: GO:0022892 ! substrate-specific transporter activity
relationship: part_of GO:0015833 ! peptide transport

[Term]
id: GO:0015198
name: oligopeptide transporter activity
namespace: molecular_function
def: "Enables the directed movement of oligopeptides into, out of or within a cell, or between cells. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0015197 ! peptide transporter activity
relationship: part_of GO:0006857 ! oligopeptide transport

[Term]
id: GO:0015199
name: amino-acid betaine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of betaine, the N-trimethyl derivative of an amino acid, from one side of the membrane to the other." [GOC:ai]
subset: gosubset_prok
synonym: "betaine transmembrane transporter activity" EXACT []
synonym: "betaine/GABA:sodium symporter activity" NARROW []
synonym: "glycine betaine/proline porter activity" NARROW []
synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" NARROW []
is_a: GO:0008519 ! ammonium transmembrane transporter activity
is_a: GO:0015651 ! quaternary ammonium group transmembrane transporter activity
is_a: GO:0072349 ! modified amino acid transmembrane transporter activity
relationship: part_of GO:0015838 ! amino-acid betaine transport

[Term]
id: GO:0015200
name: methylammonium transmembrane transporter activity
namespace: molecular_function
def: "Enables directed movement of methylammonium, CH3NH2, into, out of or within a cell, or between cells." [GOC:ai]
is_a: GO:0005275 ! amine transmembrane transporter activity
is_a: GO:0008519 ! ammonium transmembrane transporter activity
is_a: GO:0015101 ! organic cation transmembrane transporter activity
relationship: part_of GO:0072489 ! methylammonium transmembrane transport

[Term]
id: GO:0015203
name: polyamine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of polyamines, organic compounds containing two or more amino groups, from one side of the membrane to the other." [GOC:ai]
subset: gosubset_prok
synonym: "amine/amide/polyamine channel activity" RELATED []
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity
relationship: part_of GO:1902047 ! polyamine transmembrane transport

[Term]
id: GO:0015204
name: urea transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015287
def: "Enables the directed movement of urea cross a membrane into, out of or within a cell, or between cells. Urea is the water soluble compound H2N-CO-NH2." [ISBN:0198506732]
subset: gosubset_prok
synonym: "urea transporter activity" BROAD []
xref: Reactome:REACT_20655 "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively, Homo sapiens"
xref: RHEA:32802
is_a: GO:0042887 ! amide transmembrane transporter activity
relationship: part_of GO:0071918 ! urea transmembrane transport

[Term]
id: GO:0015205
name: nucleobase transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015392
def: "Enables the transfer of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acidfrom one side of a membrane to the other." [ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity
relationship: part_of GO:0015851 ! nucleobase transport

[Term]
id: GO:0015207
name: adenine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of adenine, 6-aminopurine, from one side of a membrane to the other." [GOC:go_curators]
xref: Reactome:REACT_103683 "ADP-ATP translocase maintains a high ADP:ATP ratio in the matrix, Drosophila melanogaster"
xref: Reactome:REACT_103945 "ADP-ATP translocase maintains a high ADP:ATP ratio in the matrix, Danio rerio"
xref: Reactome:REACT_104370 "ADP-ATP translocase maintains a high ADP:ATP ratio in the matrix, Canis familiaris"
xref: Reactome:REACT_106927 "ADP-ATP translocase maintains a high ADP:ATP ratio in the matrix, Sus scrofa"
xref: Reactome:REACT_114818 "ADP-ATP translocase maintains a high ADP:ATP ratio in the matrix, Arabidopsis thaliana"
xref: Reactome:REACT_115148 "ADP-ATP translocase maintains a high ADP:ATP ratio in the matrix, Oryza sativa"
xref: Reactome:REACT_28765 "ADP-ATP translocase maintains a high ADP:ATP ratio in the matrix, Rattus norvegicus"
xref: Reactome:REACT_29736 "ADP-ATP translocase maintains a high ADP:ATP ratio in the matrix, Bos taurus"
xref: Reactome:REACT_30333 "ADP-ATP translocase maintains a high ADP:ATP ratio in the matrix, Taeniopygia guttata"
xref: Reactome:REACT_89777 "ADP-ATP translocase maintains a high ADP:ATP ratio in the matrix, Mus musculus"
xref: Reactome:REACT_9011 "ADP-ATP translocase maintains a high ADP:ATP ratio in the matrix, Homo sapiens"
xref: Reactome:REACT_98182 "ADP-ATP translocase maintains a high ADP:ATP ratio in the matrix, Dictyostelium discoideum"
xref: Reactome:REACT_98685 "ADP-ATP translocase maintains a high ADP:ATP ratio in the matrix, Gallus gallus"
xref: Reactome:REACT_98792 "ADP-ATP translocase maintains a high ADP:ATP ratio in the matrix, Xenopus tropicalis"
is_a: GO:0005345 ! purine nucleobase transmembrane transporter activity
relationship: part_of GO:0015853 ! adenine transport

[Term]
id: GO:0015208
name: guanine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of guanine, 2-amino-6-hydroxypurine, from one side of a membrane to the other." [GOC:go_curators]
is_a: GO:0005345 ! purine nucleobase transmembrane transporter activity
relationship: part_of GO:0015854 ! guanine transport
relationship: part_of GO:1903716 ! guanine transmembrane transport

[Term]
id: GO:0015209
name: cytosine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of cytosine, 4-amino-2-hydroxypyrimidine from one side of a membrane to the other." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0005350 ! pyrimidine nucleobase transmembrane transporter activity
relationship: part_of GO:0015856 ! cytosine transport

[Term]
id: GO:0015210
name: uracil transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of uracil, 2,4-dioxopyrimidine, from one side of a membrane to the other." [GOC:go_curators]
subset: gosubset_prok
synonym: "uracil/uridine permease activity" RELATED []
is_a: GO:0005350 ! pyrimidine nucleobase transmembrane transporter activity
relationship: part_of GO:1903791 ! uracil transmembrane transport

[Term]
id: GO:0015211
name: purine nucleoside transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a purine nucleoside, a purine base covalently bonded to a ribose or deoxyribose sugar, from one side of a membrane to the other." [GOC:ai]
subset: gosubset_prok
is_a: GO:0005337 ! nucleoside transmembrane transporter activity
relationship: part_of GO:0015860 ! purine nucleoside transmembrane transport

[Term]
id: GO:0015212
name: cytidine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of cytidine, cytosine riboside, from one side of a membrane to the other." [GOC:go_curators]
is_a: GO:0015214 ! pyrimidine nucleoside transmembrane transporter activity
relationship: part_of GO:0015861 ! cytidine transport

[Term]
id: GO:0015213
name: uridine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of uridine, uracil riboside, from one side of a membrane to the other." [GOC:go_curators]
synonym: "uracil/uridine permease activity" NARROW []
is_a: GO:0015214 ! pyrimidine nucleoside transmembrane transporter activity
relationship: part_of GO:0015862 ! uridine transport

[Term]
id: GO:0015214
name: pyrimidine nucleoside transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a pyrimidine nucleoside, a pyrimidine base covalently bonded to a ribose or deoxyribose sugar from one side of a membrane to the other." [GOC:ai]
is_a: GO:0005337 ! nucleoside transmembrane transporter activity
relationship: part_of GO:0072531 ! pyrimidine-containing compound transmembrane transport

[Term]
id: GO:0015215
name: nucleotide transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, from one side of a membrane to the other." [ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity
is_a: GO:0015932 ! nucleobase-containing compound transmembrane transporter activity
relationship: part_of GO:1901679 ! nucleotide transmembrane transport

[Term]
id: GO:0015216
name: purine nucleotide transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a purine nucleotide, any compound consisting of a purine nucleoside esterified with (ortho)phosphate, from one side of a membrane to the other." [GOC:ai]
is_a: GO:0015215 ! nucleotide transmembrane transporter activity
relationship: part_of GO:0015865 ! purine nucleotide transport

[Term]
id: GO:0015217
name: ADP transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of ADP, adenosine diphosphate, from one side of a membrane to the other." [GOC:ai]
is_a: GO:0000295 ! adenine nucleotide transmembrane transporter activity
is_a: GO:0005346 ! purine ribonucleotide transmembrane transporter activity
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015211 ! purine nucleoside transmembrane transporter activity
relationship: part_of GO:0015866 ! ADP transport

[Term]
id: GO:0015218
name: pyrimidine nucleotide transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate, from one side of a membrane to the other." [GOC:ai]
is_a: GO:0015215 ! nucleotide transmembrane transporter activity
relationship: part_of GO:0006864 ! pyrimidine nucleotide transport

[Term]
id: GO:0015219
name: protein-DNA complex transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of protein-DNA complexes from one side of a membrane to the other." [GOC:ai]
subset: gosubset_prok
synonym: "DNA-protein complex transmembrane transporter activity" EXACT [GOC:mah]
is_a: GO:0008320 ! protein transmembrane transporter activity
is_a: GO:0051035 ! DNA transmembrane transporter activity

[Term]
id: GO:0015220
name: choline transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0005306
def: "Enables the transfer of choline from one side of the membrane to the other. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine." [GOC:ai]
subset: gosubset_prok
synonym: "amino acid/choline transmembrane transporter activity" NARROW []
synonym: "choline permease activity" EXACT []
xref: Reactome:REACT_100051 "Transport of Choline, Taeniopygia guttata"
xref: Reactome:REACT_102529 "Sodium- and chloride-dependent choline transport by CHT, Xenopus tropicalis"
xref: Reactome:REACT_106190 "Transport of Choline, Bos taurus"
xref: Reactome:REACT_106847 "Transport of Choline, Danio rerio"
xref: Reactome:REACT_107801 "Sodium- and chloride-dependent choline transport by CHT, Rattus norvegicus"
xref: Reactome:REACT_113748 "Sodium- and chloride-dependent choline transport by CHT, Staphylococcus aureus N315"
xref: Reactome:REACT_115008 "Transport of Choline, Staphylococcus aureus N315"
xref: Reactome:REACT_15552 "Transport of Choline, Homo sapiens"
xref: Reactome:REACT_20595 "Sodium- and chloride-dependent choline transport by CHT, Homo sapiens"
xref: Reactome:REACT_20598 "Cho transports from the extracellular space to the cytosol, Homo sapiens"
xref: Reactome:REACT_30987 "Sodium- and chloride-dependent choline transport by CHT, Caenorhabditis elegans"
xref: Reactome:REACT_33806 "Sodium- and chloride-dependent choline transport by CHT, Danio rerio"
xref: Reactome:REACT_34154 "Sodium- and chloride-dependent choline transport by CHT, Sus scrofa"
xref: Reactome:REACT_66893 "Transport of Choline, Mus musculus"
xref: Reactome:REACT_77852 "Sodium- and chloride-dependent choline transport by CHT, Drosophila melanogaster"
xref: Reactome:REACT_78711 "Transport of Choline, Canis familiaris"
xref: Reactome:REACT_81018 "Sodium- and chloride-dependent choline transport by CHT, Gallus gallus"
xref: Reactome:REACT_84366 "Transport of Choline, Rattus norvegicus"
xref: Reactome:REACT_84940 "Transport of Choline, Xenopus tropicalis"
xref: Reactome:REACT_85892 "Sodium- and chloride-dependent choline transport by CHT, Bos taurus"
xref: Reactome:REACT_88764 "Sodium- and chloride-dependent choline transport by CHT, Taeniopygia guttata"
xref: Reactome:REACT_91179 "Transport of Choline, Caenorhabditis elegans"
xref: Reactome:REACT_92371 "Transport of Choline, Gallus gallus"
xref: Reactome:REACT_93179 "Transport of Choline, Drosophila melanogaster"
xref: Reactome:REACT_94715 "Transport of Choline, Sus scrofa"
xref: Reactome:REACT_96626 "Sodium- and chloride-dependent choline transport by CHT, Mus musculus"
xref: Reactome:REACT_99282 "Sodium- and chloride-dependent choline transport by CHT, Canis familiaris"
is_a: GO:0008519 ! ammonium transmembrane transporter activity
is_a: GO:0015665 ! alcohol transmembrane transporter activity
relationship: part_of GO:0015871 ! choline transport

[Term]
id: GO:0015221
name: lipopolysaccharide transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of lipopolysaccharides from one side of the membrane to the other. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "LPS transmembrane transporter activity" EXACT []
is_a: GO:0005319 ! lipid transporter activity
is_a: GO:0022884 ! macromolecule transmembrane transporter activity
is_a: GO:1901505 ! carbohydrate derivative transporter activity

[Term]
id: GO:0015222
name: serotonin transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of serotonin from one side of the membrane to the other. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems." [GOC:ai]
is_a: GO:0008504 ! monoamine transmembrane transporter activity
is_a: GO:0008519 ! ammonium transmembrane transporter activity
is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity
relationship: part_of GO:0006837 ! serotonin transport

[Term]
id: GO:0015223
name: obsolete vitamin or cofactor transporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the directed transport of vitamins or cofactors into, out of or within a cell, or between cells." [GOC:ai]
comment: This term was made obsolete because it was replaced by more specific terms.
synonym: "vitamin or cofactor transporter activity" EXACT []
synonym: "vitamin/cofactor transporter activity" EXACT []
is_obsolete: true
consider: GO:0051183
consider: GO:0051184

[Term]
id: GO:0015224
name: biopterin transporter activity
namespace: molecular_function
def: "Enables the directed movement of biopterin into, out of or within a cell, or between cells. Biopterin is a growth factor for certain protozoans and some insects; it is widely distributed in tissues and functions in a reduced form, tetrahydrobiopterin, as a hydroxylation coenzyme." [ISBN:0198506732]
is_a: GO:0051184 ! cofactor transporter activity
relationship: part_of GO:0015877 ! biopterin transport

[Term]
id: GO:0015225
name: biotin transporter activity
namespace: molecular_function
def: "Enables the directed movement of biotin into, out of or within a cell, or between cells. Biotin is cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions." [GOC:ai]
synonym: "vitamin B7 transporter activity" EXACT []
synonym: "vitamin H transporter activity" EXACT []
xref: RHEA:28461
is_a: GO:0051183 ! vitamin transporter activity
is_a: GO:0051184 ! cofactor transporter activity
relationship: part_of GO:0015878 ! biotin transport

[Term]
id: GO:0015226
name: carnitine transmembrane transporter activity
namespace: molecular_function
def: "Enables the directed movement of carnitine across a membrane. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:ai]
subset: gosubset_prok
synonym: "vitamin Bt transporter activity" EXACT []
xref: Reactome:REACT_22187 "Carnitine transporters mediates sodium-dependent uptake of carnitine, Homo sapiens"
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:0015199 ! amino-acid betaine transmembrane transporter activity
is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity
relationship: part_of GO:1902603 ! carnitine transmembrane transport

[Term]
id: GO:0015227
name: acyl carnitine transmembrane transporter activity
namespace: molecular_function
def: "Enables the directed movement of acyl carnitine across a membrane. Acyl carnitine is the condensation product of a carboxylic acid and carnitine and is the transport form for a fatty acid crossing the mitochondrial membrane." [CHEBI:17387, GOC:ai]
synonym: "acylcarnitine transporter activity" BROAD []
xref: Reactome:REACT_109139 "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane, Danio rerio"
xref: Reactome:REACT_109156 "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane, Gallus gallus"
xref: Reactome:REACT_110847 "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane, Sus scrofa"
xref: Reactome:REACT_11180 "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane, Homo sapiens"
xref: Reactome:REACT_112186 "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane, Schizosaccharomyces pombe"
xref: Reactome:REACT_33596 "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane, Canis familiaris"
xref: Reactome:REACT_77288 "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane, Drosophila melanogaster"
xref: Reactome:REACT_82427 "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane, Mus musculus"
xref: Reactome:REACT_83082 "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane, Xenopus tropicalis"
xref: Reactome:REACT_83725 "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane, Bos taurus"
xref: Reactome:REACT_90417 "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane, Caenorhabditis elegans"
xref: Reactome:REACT_95462 "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane, Rattus norvegicus"
xref: Reactome:REACT_96241 "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane, Taeniopygia guttata"
xref: Reactome:REACT_98496 "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane, Saccharomyces cerevisiae"
is_a: GO:0015651 ! quaternary ammonium group transmembrane transporter activity
relationship: part_of GO:1902616 ! acyl carnitine transmembrane transport

[Term]
id: GO:0015228
name: coenzyme A transmembrane transporter activity
namespace: molecular_function
def: "Enables the directed movement of coenzyme A across a membrane into, out of or within a cell, or between cells. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [GOC:ai]
synonym: "coenzyme A transporter activity" BROAD []
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0051185 ! coenzyme transporter activity
is_a: GO:0071077 ! adenosine 3',5'-bisphosphate transmembrane transporter activity
relationship: part_of GO:0035349 ! coenzyme A transmembrane transport

[Term]
id: GO:0015229
name: L-ascorbic acid transporter activity
namespace: molecular_function
def: "Enables the directed movement of L-ascorbate into, out of or within a cell, or between cells. L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, is vitamin C and has co-factor and anti-oxidant activities in many species." [CHEBI:38290, ISBN:0198506732]
synonym: "L-ascorbate transporter activity" EXACT []
synonym: "vitamin C transporter activity" EXACT []
xref: Reactome:REACT_102651 "Ascorbate transport across the plasma membrane, Drosophila melanogaster"
xref: Reactome:REACT_103216 "Ascorbate transport across the plasma membrane, Danio rerio"
xref: Reactome:REACT_107543 "Ascorbate transport across the plasma membrane, Bos taurus"
xref: Reactome:REACT_108409 "Ascorbate transport across the plasma membrane, Canis familiaris"
xref: Reactome:REACT_11120 "Ascorbate transport across the plasma membrane, Homo sapiens"
xref: Reactome:REACT_33834 "Ascorbate transport across the plasma membrane, Taeniopygia guttata"
xref: Reactome:REACT_85252 "Ascorbate transport across the plasma membrane, Sus scrofa"
xref: Reactome:REACT_87780 "Ascorbate transport across the plasma membrane, Xenopus tropicalis"
xref: Reactome:REACT_89713 "Ascorbate transport across the plasma membrane, Oryza sativa"
xref: Reactome:REACT_91214 "Ascorbate transport across the plasma membrane, Gallus gallus"
xref: Reactome:REACT_97356 "Ascorbate transport across the plasma membrane, Rattus norvegicus"
xref: Reactome:REACT_98551 "Ascorbate transport across the plasma membrane, Arabidopsis thaliana"
xref: Reactome:REACT_98876 "Ascorbate transport across the plasma membrane, Mus musculus"
is_a: GO:0051183 ! vitamin transporter activity
is_a: GO:1901476 ! carbohydrate transporter activity
relationship: part_of GO:0015882 ! L-ascorbic acid transport

[Term]
id: GO:0015230
name: FAD transmembrane transporter activity
namespace: molecular_function
def: "Enables the directed movement of flavin-adenine dinucleotide (FAD) across a membrane into, out of or within a cell, or between cells. FAD forms the coenzyme of the prosthetic group of various flavoprotein oxidoreductase enzymes, in which it functions as an electron acceptor by being reversibly converted to its reduced form." [ISBN:0198506732]
synonym: "FAD transporter activity" BROAD []
synonym: "flavin adenine dinucleotide transmembrane transporter activity" EXACT []
synonym: "flavin-adenine dinucleotide transmembrane transporter activity" EXACT []
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015215 ! nucleotide transmembrane transporter activity
is_a: GO:0051184 ! cofactor transporter activity
relationship: part_of GO:0035350 ! FAD transmembrane transport

[Term]
id: GO:0015231
name: 5-formyltetrahydrofolate transporter activity
namespace: molecular_function
def: "Enables the directed movement of 5-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate, into, out of, within, or between cells." [GOC:ai]
is_a: GO:0008517 ! folic acid transporter activity
relationship: part_of GO:0015885 ! 5-formyltetrahydrofolate transport

[Term]
id: GO:0015232
name: heme transporter activity
namespace: molecular_function
def: "Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of or within a cell, or between cells." [GOC:ai]
subset: gosubset_prok
synonym: "haem transporter activity" EXACT []
xref: Reactome:REACT_100385 "ABC7, mABC1 and mABC2 mediate heme transport, Dictyostelium discoideum"
xref: Reactome:REACT_104882 "ABC7, mABC1 and mABC2 mediate heme transport, Oryza sativa"
xref: Reactome:REACT_104909 "ABC7, mABC1 and mABC2 mediate heme transport, Schizosaccharomyces pombe"
xref: Reactome:REACT_105656 "ABC7, mABC1 and mABC2 mediate heme transport, Taeniopygia guttata"
xref: Reactome:REACT_106955 "ABC7, mABC1 and mABC2 mediate heme transport, Saccharomyces cerevisiae"
xref: Reactome:REACT_109850 "ABC7, mABC1 and mABC2 mediate heme transport, Drosophila melanogaster"
xref: Reactome:REACT_110140 "ABC7, mABC1 and mABC2 mediate heme transport, Danio rerio"
xref: Reactome:REACT_111156 "MTABC3 transports porphyrin into mitochondria, Homo sapiens"
xref: Reactome:REACT_112680 "ABC7, mABC1 and mABC2 mediate heme transport, Mycobacterium tuberculosis"
xref: Reactome:REACT_114177 "ABC7, mABC1 and mABC2 mediate heme transport, Staphylococcus aureus N315"
xref: Reactome:REACT_114591 "ABC7, mABC1 and mABC2 mediate heme transport, Plasmodium falciparum"
xref: Reactome:REACT_22342 "ABC7, mABC1 and mABC2 mediate heme transport, Homo sapiens"
xref: Reactome:REACT_25025 "Extracellular ferriheme uptake through the apical membrane of enterocytes, Homo sapiens"
xref: Reactome:REACT_25155 "Export of heme to the blood by ABCG2, Homo sapiens"
xref: Reactome:REACT_25203 "Export of heme to the blood by FLVCR, Homo sapiens"
xref: Reactome:REACT_29208 "ABC7, mABC1 and mABC2 mediate heme transport, Caenorhabditis elegans"
xref: Reactome:REACT_34709 "ABC7, mABC1 and mABC2 mediate heme transport, Sus scrofa"
xref: Reactome:REACT_77717 "ABC7, mABC1 and mABC2 mediate heme transport, Mus musculus"
xref: Reactome:REACT_78473 "ABC7, mABC1 and mABC2 mediate heme transport, Canis familiaris"
xref: Reactome:REACT_82495 "ABC7, mABC1 and mABC2 mediate heme transport, Arabidopsis thaliana"
xref: Reactome:REACT_88411 "ABC7, mABC1 and mABC2 mediate heme transport, Bos taurus"
xref: Reactome:REACT_94308 "ABC7, mABC1 and mABC2 mediate heme transport, Gallus gallus"
xref: Reactome:REACT_97364 "ABC7, mABC1 and mABC2 mediate heme transport, Xenopus tropicalis"
xref: Reactome:REACT_97806 "ABC7, mABC1 and mABC2 mediate heme transport, Rattus norvegicus"
is_a: GO:0051184 ! cofactor transporter activity
relationship: part_of GO:0015886 ! heme transport

[Term]
id: GO:0015233
name: pantothenate transmembrane transporter activity
namespace: molecular_function
def: "Enables the directed movement of pantothenate across a membrane. Pantothenate is the anion of pantothenic acid, the amide of beta-alanine and pantoic acid; it is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods." [GOC:ai, ISBN:0721662544]
subset: gosubset_prok
synonym: "pantothenate transporter activity" BROAD [GOC:mah]
synonym: "vitamin B5 transmembrane transporter activity" EXACT []
is_a: GO:0042887 ! amide transmembrane transporter activity
is_a: GO:0051185 ! coenzyme transporter activity
is_a: GO:0072349 ! modified amino acid transmembrane transporter activity
is_a: GO:0090482 ! vitamin transmembrane transporter activity
relationship: part_of GO:0015887 ! pantothenate transmembrane transport

[Term]
id: GO:0015234
name: thiamine transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015402
def: "Enables the transfer of thiamine from one side of the membrane to the other. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "thiamin permease activity" EXACT []
synonym: "thiamin transmembrane transporter activity" EXACT [GOC:curators]
synonym: "thiamine permease activity" EXACT []
synonym: "vitamin B1 transporter activity" EXACT []
xref: Reactome:REACT_107661 "Thiamin transport across the plasma membrane, Bos taurus"
xref: Reactome:REACT_109497 "Thiamin transport across the plasma membrane, Rattus norvegicus"
xref: Reactome:REACT_109778 "Thiamin transport across the plasma membrane, Dictyostelium discoideum"
xref: Reactome:REACT_110199 "Thiamin transport across the plasma membrane, Mus musculus"
xref: Reactome:REACT_11081 "Thiamin transport across the plasma membrane, Homo sapiens"
xref: Reactome:REACT_79884 "Thiamin transport across the plasma membrane, Sus scrofa"
xref: Reactome:REACT_81905 "Thiamin transport across the plasma membrane, Gallus gallus"
xref: Reactome:REACT_83103 "Thiamin transport across the plasma membrane, Taeniopygia guttata"
xref: Reactome:REACT_86139 "Thiamin transport across the plasma membrane, Xenopus tropicalis"
xref: Reactome:REACT_88181 "Thiamin transport across the plasma membrane, Canis familiaris"
xref: Reactome:REACT_89104 "Thiamin transport across the plasma membrane, Drosophila melanogaster"
xref: Reactome:REACT_93062 "Thiamin transport across the plasma membrane, Caenorhabditis elegans"
xref: Reactome:REACT_95827 "Thiamin transport across the plasma membrane, Danio rerio"
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity
is_a: GO:0090482 ! vitamin transmembrane transporter activity
is_a: GO:1901474 ! azole transmembrane transporter activity
is_a: GO:1901682 ! sulfur compound transmembrane transporter activity
relationship: part_of GO:0071934 ! thiamine transmembrane transport

[Term]
id: GO:0015235
name: cobalamin transporter activity
namespace: molecular_function
def: "Enables the directed movement of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom, into, out of or within a cell." [GOC:ai]
subset: gosubset_prok
synonym: "vitamin B12 transporter activity" EXACT []
xref: RHEA:32834
is_a: GO:0051183 ! vitamin transporter activity
relationship: part_of GO:0015889 ! cobalamin transport

[Term]
id: GO:0015238
name: drug transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015239
alt_id: GO:0015559
alt_id: GO:0015564
def: "Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease." [ISBN:0198506732]
subset: gosubset_prok
synonym: "multidrug efflux pump activity" RELATED []
synonym: "multidrug transporter activity" RELATED []
synonym: "multidrug, alkane resistant pump activity" RELATED []
is_a: GO:0022857 ! transmembrane transporter activity
is_a: GO:0090484 ! drug transporter activity
relationship: part_of GO:0006855 ! drug transmembrane transport

[Term]
id: GO:0015240
name: amiloride transporter activity
namespace: molecular_function
def: "Enables the directed movement of amiloride into, out of or within a cell, or between cells. Amiloride is a potent and specific inhibitor of sodium ion entry into cells. It is used as a potassium-sparing diuretic." [ISBN:0198506732]
is_a: GO:0090484 ! drug transporter activity
relationship: part_of GO:0015898 ! amiloride transport

[Term]
id: GO:0015241
name: aminotriazole transporter activity
namespace: molecular_function
def: "Enables the directed movement of aminotriazole into, out of or within a cell, or between cells. Aminotriazole is an effective weed killer that also possesses some antithyroid activity." [CHEBI:40036, GOC:curators]
is_a: GO:0045118 ! azole transporter activity
relationship: part_of GO:0015899 ! aminotriazole transport

[Term]
id: GO:0015242
name: benomyl transporter activity
namespace: molecular_function
def: "Enables the directed movement of benomyl into, out of or within a cell, or between cells. Benomyl, methyl 1-(butylcarbamoyl)-2-benzimidazolecarbamate, is a systemic agricultural fungicide used for control of certain fungal diseases of stone fruit." [CHEBI:3015, GOC:curators]
is_a: GO:0042910 ! xenobiotic transporter activity
is_a: GO:0090484 ! drug transporter activity
relationship: part_of GO:0015900 ! benomyl transport

[Term]
id: GO:0015243
name: cycloheximide transporter activity
namespace: molecular_function
def: "Enables the directed movement of cycloheximide into, out of or within a cell, or between cells. Cycloheximide is an antibiotic produced by Streptomyces which interferes with protein synthesis in eukaryotes." [ISBN:0198506732]
is_a: GO:0042895 ! antibiotic transporter activity
relationship: part_of GO:0015901 ! cycloheximide transport

[Term]
id: GO:0015244
name: fluconazole transporter activity
namespace: molecular_function
def: "Enables the directed movement of fluconazole into, out of or within a cell, or between cells. Fluconazole is an antifungal drug used for oral candidiasis and cryptococcal meningitis; it is still under study for treatment of vaginal candidiasis and other fungal infections." [CHEBI:46081, GOC:curators]
is_a: GO:0045118 ! azole transporter activity
relationship: part_of GO:0015903 ! fluconazole transport

[Term]
id: GO:0015245
name: fatty acid transporter activity
namespace: molecular_function
def: "Enables the directed movement of fatty acids into, out of or within a cell, or between cells. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198506732]
subset: gosubset_prok
xref: Reactome:REACT_23817 "FATP1, 4 and 6 can mediate the influx of long chain fatty acids into cells, Homo sapiens"
is_a: GO:0005319 ! lipid transporter activity
relationship: part_of GO:0015908 ! fatty acid transport

[Term]
id: GO:0015246
name: fatty-acyl group transporter activity
namespace: molecular_function
def: "Enables the directed movement of a fatty acyl group into, out of or within a cell, or between cells. A fatty acyl group is any acyl group derived from a fatty acid." [ISBN:0198506732]
synonym: "fatty acyl transporter activity" EXACT [GOC:curators]
synonym: "peroxisomal fatty acyl transporter" NARROW []
is_a: GO:0005319 ! lipid transporter activity
relationship: part_of GO:0015915 ! fatty-acyl group transport

[Term]
id: GO:0015247
name: aminophospholipid transporter activity
namespace: molecular_function
def: "Enables the directed movement of aminophospholipids into, out of or within a cell, or between cells. Aminophospholipids contain phosphoric acid as a mono- or diester and an amino (NH2) group." [GOC:ai]
subset: gosubset_prok
is_a: GO:0005548 ! phospholipid transporter activity
relationship: part_of GO:0015917 ! aminophospholipid transport

[Term]
id: GO:0015248
name: sterol transporter activity
namespace: molecular_function
def: "Enables the directed movement of sterols into, out of or within a cell, or between cells. Sterol are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:ai]
xref: Reactome:REACT_101786 "ABCG5:ABCG8-mediated export of cholesterol and phytosterols, Taeniopygia guttata"
xref: Reactome:REACT_102422 "ABCG5:ABCG8-mediated export of cholesterol and phytosterols, Canis familiaris"
xref: Reactome:REACT_113802 "ABCG5:ABCG8-mediated export of cholesterol and phytosterols, Saccharomyces cerevisiae"
xref: Reactome:REACT_114568 "ABCG5:ABCG8-mediated export of cholesterol and phytosterols, Mycobacterium tuberculosis"
xref: Reactome:REACT_114596 "ABCG5:ABCG8-mediated export of cholesterol and phytosterols, Drosophila melanogaster"
xref: Reactome:REACT_13440 "ABCG5:ABCG8-mediated export of cholesterol and phytosterols, Homo sapiens"
xref: Reactome:REACT_30767 "ABCG5:ABCG8-mediated export of cholesterol and phytosterols, Rattus norvegicus"
xref: Reactome:REACT_92351 "ABCG5:ABCG8-mediated export of cholesterol and phytosterols, Mus musculus"
xref: Reactome:REACT_92628 "ABCG5:ABCG8-mediated export of cholesterol and phytosterols, Gallus gallus"
xref: Reactome:REACT_94693 "ABCG5:ABCG8-mediated export of cholesterol and phytosterols, Xenopus tropicalis"
xref: Reactome:REACT_97018 "ABCG5:ABCG8-mediated export of cholesterol and phytosterols, Danio rerio"
xref: Reactome:REACT_99082 "ABCG5:ABCG8-mediated export of cholesterol and phytosterols, Bos taurus"
xref: Reactome:REACT_99957 "ABCG5:ABCG8-mediated export of cholesterol and phytosterols, Sus scrofa"
is_a: GO:0005319 ! lipid transporter activity
relationship: part_of GO:0015918 ! sterol transport

[Term]
id: GO:0015250
name: water channel activity
namespace: molecular_function
def: "Transport systems of this type enable facilitated diffusion of water (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "aquaporin" NARROW []
xref: Reactome:REACT_104951 "Passive Transport of Water out of Cell by Aquaporin-3, Sus scrofa"
xref: Reactome:REACT_105076 "Passive Transport of Water out of Cell by Aquaporin-3, Taeniopygia guttata"
xref: Reactome:REACT_107376 "Passive Transport of Water out of Cell by Aquaporin-3, Mus musculus"
xref: Reactome:REACT_108926 "Passive Transport of Water out of Cell by Aquaporin-3, Rattus norvegicus"
xref: Reactome:REACT_109554 "Passive Transport of Water out of Cell by Aquaporin-3, Schizosaccharomyces pombe"
xref: Reactome:REACT_118068 "Passive Transport of Water out of Cell by Aquaporin-4, Gallus gallus"
xref: Reactome:REACT_118073 "Passive Transport of Water into Cell by Aquaporin-2 Phosphorylated on Serine256, Rattus norvegicus"
xref: Reactome:REACT_118105 "Passive Transport of Water out of Cell by Aquaporin-4, Danio rerio"
xref: Reactome:REACT_118106 "Passive Transport of Water out of Cell by Aquaporin-4, Canis familiaris"
xref: Reactome:REACT_118131 "Passive Transport of Water into Cell by Aquaporin-2 Phosphorylated on Serine256, Escherichia coli"
xref: Reactome:REACT_118156 "Passive Transport of Water out of Cell by Aquaporin-4, Mus musculus"
xref: Reactome:REACT_118170 "Passive Transport of Water out of Cell by Aquaporin-4, Rattus norvegicus"
xref: Reactome:REACT_118171 "Passive Transport of Water out of Cell by Aquaporin-1, Canis familiaris"
xref: Reactome:REACT_118179 "Passive Transport of Water into Cell by Aquaporin-1, Escherichia coli"
xref: Reactome:REACT_118185 "Passive Transport of Water into Cell by Aquaporin-2 Phosphorylated on Serine256, Taeniopygia guttata"
xref: Reactome:REACT_118189 "Passive Transport of Water out of Cell by Aquaporin-1, Rattus norvegicus"
xref: Reactome:REACT_118190 "Passive Transport of Water into Cell by Aquaporin-2 Phosphorylated on Serine256, Mus musculus"
xref: Reactome:REACT_118192 "Passive Transport of Water into Cell by Aquaporin-2 Phosphorylated on Serine256, Xenopus tropicalis"
xref: Reactome:REACT_118196 "Passive Transport of Water out of Cell by Aquaporin-1, Danio rerio"
xref: Reactome:REACT_118219 "Passive Transport of Water into Cell by Aquaporin-2 Phosphorylated on Serine256, Saccharomyces cerevisiae"
xref: Reactome:REACT_118222 "Passive Transport of Water out of Cell by Aquaporin-1, Escherichia coli"
xref: Reactome:REACT_118225 "Passive Transport of Water out of Cell by Aquaporin-4, Saccharomyces cerevisiae"
xref: Reactome:REACT_118228 "Passive Transport of Water into Cell by Aquaporin-2 Phosphorylated on Serine256, Drosophila melanogaster"
xref: Reactome:REACT_118234 "Passive Transport of Water into Cell by Aquaporin-2 Phosphorylated on Serine256, Gallus gallus"
xref: Reactome:REACT_118238 "Passive Transport of Water into Cell by Aquaporin-1, Danio rerio"
xref: Reactome:REACT_118265 "Passive Transport of Water out of Cell by Aquaporin-1, Saccharomyces cerevisiae"
xref: Reactome:REACT_118266 "Passive Transport of Water into Cell by Aquaporin-1, Saccharomyces cerevisiae"
xref: Reactome:REACT_118272 "Passive Transport of Water out of Cell by Aquaporin-4, Taeniopygia guttata"
xref: Reactome:REACT_118299 "Passive Transport of Water into Cell by Aquaporin-1, Gallus gallus"
xref: Reactome:REACT_118300 "Passive Transport of Water into Cell by Aquaporin-1, Taeniopygia guttata"
xref: Reactome:REACT_118332 "Passive Transport of Water into Cell by Aquaporin-1, Rattus norvegicus"
xref: Reactome:REACT_118334 "Passive Transport of Water into Cell by Aquaporin-1, Mus musculus"
xref: Reactome:REACT_118363 "Passive Transport of Water out of Cell by Aquaporin-4, Drosophila melanogaster"
xref: Reactome:REACT_118372 "Passive Transport of Water out of Cell by Aquaporin-4, Sus scrofa"
xref: Reactome:REACT_118389 "Passive Transport of Water out of Cell by Aquaporin-1, Gallus gallus"
xref: Reactome:REACT_118401 "Passive Transport of Water out of Cell by Aquaporin-1, Taeniopygia guttata"
xref: Reactome:REACT_118405 "Passive Transport of Water out of Cell by Aquaporin-1, Mus musculus"
xref: Reactome:REACT_118409 "Passive Transport of Water into Cell by Aquaporin-1, Canis familiaris"
xref: Reactome:REACT_118421 "Passive Transport of Water out of Cell by Aquaporin-4, Bos taurus"
xref: Reactome:REACT_118458 "Passive Transport of Water out of Cell by Aquaporin-4, Xenopus tropicalis"
xref: Reactome:REACT_118505 "Passive Transport of Water into Cell by Aquaporin-1, Bos taurus"
xref: Reactome:REACT_118510 "Passive Transport of Water out of Cell by Aquaporin-1, Bos taurus"
xref: Reactome:REACT_118524 "Passive Transport of Water out of Cell by Aquaporin-4, Escherichia coli"
xref: Reactome:REACT_118547 "Passive Transport of Water into Cell by Aquaporin-2 Phosphorylated on Serine256, Bos taurus"
xref: Reactome:REACT_118555 "Passive Transport of Water into Cell by Aquaporin-2 Phosphorylated on Serine256, Sus scrofa"
xref: Reactome:REACT_23786 "Passive Transport of Water out of Cell by Aquaporin-1, Homo sapiens"
xref: Reactome:REACT_23788 "Passive Transport of Water into Cell by Aquaporin-2 Phosphorylated on Serine256, Homo sapiens"
xref: Reactome:REACT_23789 "Passive Transport of Water out of Cell by Aquaporin-3, Homo sapiens"
xref: Reactome:REACT_23841 "Passive Transport of Water into Cell by Aquaporin-1, Homo sapiens"
xref: Reactome:REACT_23851 "Passive Transport of Water out of Cells by Aquaporins, Homo sapiens"
xref: Reactome:REACT_23858 "Passive Transport of Water into Cells by Aquaporins, Homo sapiens"
xref: Reactome:REACT_24005 "Passive Transport of Water out of Cell by Aquaporin-4, Homo sapiens"
xref: Reactome:REACT_28668 "Passive Transport of Water out of Cell by Aquaporin-3, Canis familiaris"
xref: Reactome:REACT_84360 "Passive Transport of Water out of Cell by Aquaporin-3, Saccharomyces cerevisiae"
xref: Reactome:REACT_84611 "Passive Transport of Water out of Cell by Aquaporin-3, Staphylococcus aureus N315"
xref: Reactome:REACT_84987 "Passive Transport of Water out of Cell by Aquaporin-3, Xenopus tropicalis"
xref: Reactome:REACT_85100 "Passive Transport of Water out of Cell by Aquaporin-3, Bos taurus"
xref: Reactome:REACT_87219 "Passive Transport of Water out of Cell by Aquaporin-3, Gallus gallus"
xref: Reactome:REACT_87482 "Passive Transport of Water out of Cell by Aquaporin-3, Danio rerio"
xref: Reactome:REACT_89405 "Passive Transport of Water out of Cell by Aquaporin-3, Plasmodium falciparum"
xref: Reactome:REACT_92718 "Passive Transport of Water out of Cell by Aquaporin-3, Escherichia coli"
is_a: GO:0005372 ! water transmembrane transporter activity
is_a: GO:0022838 ! substrate-specific channel activity

[Term]
id: GO:0015251
name: ammonium channel activity
namespace: molecular_function
def: "Enables the facilitated diffusion of ammonium (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]
is_a: GO:0005261 ! cation channel activity
is_a: GO:0008519 ! ammonium transmembrane transporter activity

[Term]
id: GO:0015252
name: hydrogen ion channel activity
namespace: molecular_function
def: "Enables the facilitated diffusion of a hydrogen ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]
is_a: GO:0005261 ! cation channel activity
relationship: part_of GO:0015992 ! proton transport

[Term]
id: GO:0015253
name: obsolete sugar/polyol channel activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents two molecular functions.
synonym: "sugar/polyol channel activity" EXACT []
is_obsolete: true
consider: GO:0015166
consider: GO:0051119

[Term]
id: GO:0015254
name: glycerol channel activity
namespace: molecular_function
def: "Enables the facilitated diffusion of glycerol (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729]
xref: Reactome:REACT_118065 "Passive Transport of Glycerol out of Cell by Aquaporin-7, Taeniopygia guttata"
xref: Reactome:REACT_118076 "Passive Transport of Glycerol into Cell by Aquaporin-9, Rattus norvegicus"
xref: Reactome:REACT_118110 "Passive Transport of Glycerol into Cell by Aquaporin-9, Saccharomyces cerevisiae"
xref: Reactome:REACT_118125 "Passive Transport of Glycerol out of Cell by Aquaporin-7, Gallus gallus"
xref: Reactome:REACT_118144 "Passive Transport of Glycerol into Cell by Aquaporin-9, Bos taurus"
xref: Reactome:REACT_118149 "Passive Transport of Glycerol out of Cell by Aquaporin-7, Escherichia coli"
xref: Reactome:REACT_118157 "Passive Transport of Glycerol into Cell by Aquaporin-9, Escherichia coli"
xref: Reactome:REACT_118188 "Passive Transport of Glycerol into Cell by Aquaporin-9, Plasmodium falciparum"
xref: Reactome:REACT_118191 "Passive Transport of Glycerol out of Cell by Aquaporin-7, Sus scrofa"
xref: Reactome:REACT_118215 "Passive Transport of Glycerol into Cell by Aquaporin-9, Sus scrofa"
xref: Reactome:REACT_118221 "Passive Transport of Glycerol out of Cell by Aquaporin-7, Bos taurus"
xref: Reactome:REACT_118243 "Passive Transport of Glycerol out of Cell by Aquaporin-7, Saccharomyces cerevisiae"
xref: Reactome:REACT_118263 "Passive Transport of Glycerol into Cell by Aquaporin-9, Staphylococcus aureus N315"
xref: Reactome:REACT_118286 "Passive Transport of Glycerol out of Cell by Aquaporin-7, Xenopus tropicalis"
xref: Reactome:REACT_118305 "Passive Transport of Glycerol out of Cell by Aquaporin-7, Canis familiaris"
xref: Reactome:REACT_118320 "Passive Transport of Glycerol into Cell by Aquaporin-9, Schizosaccharomyces pombe"
xref: Reactome:REACT_118342 "Passive Transport of Glycerol into Cell by Aquaporin-9, Canis familiaris"
xref: Reactome:REACT_118383 "Passive Transport of Glycerol into Cell by Aquaporin-9, Danio rerio"
xref: Reactome:REACT_118394 "Passive Transport of Glycerol out of Cell by Aquaporin-7, Staphylococcus aureus N315"
xref: Reactome:REACT_118404 "Passive Transport of Glycerol out of Cell by Aquaporin-7, Danio rerio"
xref: Reactome:REACT_118429 "Passive Transport of Glycerol into Cell by Aquaporin-9, Taeniopygia guttata"
xref: Reactome:REACT_118430 "Passive Transport of Glycerol out of Cell by Aquaporin-7, Schizosaccharomyces pombe"
xref: Reactome:REACT_118444 "Passive Transport of Glycerol out of Cell by Aquaporin-7, Mus musculus"
xref: Reactome:REACT_118497 "Passive Transport of Glycerol into Cell by Aquaporin-9, Gallus gallus"
xref: Reactome:REACT_118501 "Passive Transport of Glycerol out of Cell by Aquaporin-7, Plasmodium falciparum"
xref: Reactome:REACT_118512 "Passive Transport of Glycerol into Cell by Aquaporin-9, Mus musculus"
xref: Reactome:REACT_118527 "Passive Transport of Glycerol out of Cell by Aquaporin-7, Rattus norvegicus"
xref: Reactome:REACT_118551 "Passive Transport of Glycerol into Cell by Aquaporin-9, Xenopus tropicalis"
xref: Reactome:REACT_23780 "Passive Transport of Glycerol out of Cells by Aquaporins, Homo sapiens"
xref: Reactome:REACT_23873 "Passive Transport of Glycerol out of Cell by Aquaporin-7, Homo sapiens"
xref: Reactome:REACT_23921 "Passive Transport of Glycerol into Cells by Aquaporins, Homo sapiens"
xref: Reactome:REACT_23966 "Passive Transport of Glycerol into Cell by Aquaporin-9, Homo sapiens"
is_a: GO:0015168 ! glycerol transmembrane transporter activity
is_a: GO:0015267 ! channel activity

[Term]
id: GO:0015255
name: propanediol channel activity
namespace: molecular_function
def: "Enables the facilitated diffusion of propanediol (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport]
is_a: GO:0015170 ! propanediol transmembrane transporter activity
is_a: GO:0015267 ! channel activity

[Term]
id: GO:0015256
name: obsolete monocarboxylate channel activity
namespace: molecular_function
def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729]
comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel.
synonym: "monocarboxylate channel activity" EXACT []
is_obsolete: true

[Term]
id: GO:0015257
name: obsolete organic anion channel activity
namespace: molecular_function
def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729]
comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel.
synonym: "organic anion channel activity" EXACT []
is_obsolete: true

[Term]
id: GO:0015258
name: obsolete gluconate channel activity
namespace: molecular_function
def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729]
comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel.
synonym: "gluconate channel activity" EXACT []
is_obsolete: true

[Term]
id: GO:0015259
name: obsolete glutamate channel activity
namespace: molecular_function
def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729]
comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel.
synonym: "glutamate channel activity" EXACT []
is_obsolete: true

[Term]
id: GO:0015260
name: obsolete isethionate channel activity
namespace: molecular_function
def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729]
comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel.
synonym: "isethionate channel activity" EXACT []
is_obsolete: true

[Term]
id: GO:0015261
name: obsolete lactate channel activity
namespace: molecular_function
def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729]
comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel.
synonym: "lactate channel activity" EXACT []
is_obsolete: true

[Term]
id: GO:0015262
name: obsolete taurine channel activity
namespace: molecular_function
def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729]
comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel.
synonym: "taurine channel activity" EXACT []
is_obsolete: true

[Term]
id: GO:0015263
name: obsolete amine/amide/polyamine channel activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents three molecular functions.
synonym: "amine/amide/polyamine channel activity" EXACT []
is_obsolete: true
consider: GO:0005275
consider: GO:0015203
consider: GO:0042887

[Term]
id: GO:0015264
name: methylammonium channel activity
namespace: molecular_function
def: "Enables the facilitated diffusion of methylammonium (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. Methylammonium is CH3NH2." [GOC:mtg_transport, GOC:pr]
is_a: GO:0015200 ! methylammonium transmembrane transporter activity
is_a: GO:0015251 ! ammonium channel activity

[Term]
id: GO:0015265
name: urea channel activity
namespace: molecular_function
def: "Enables the facilitated diffusion of urea (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport]
xref: Reactome:REACT_23825 "Passive Transport of Urea into Cells by Aquaporins, Homo sapiens"
xref: Reactome:REACT_23949 "Passive Transport of Urea out of Cells by Aquaporins, Homo sapiens"
is_a: GO:0015204 ! urea transmembrane transporter activity
is_a: GO:0022838 ! substrate-specific channel activity

[Term]
id: GO:0015266
name: protein channel activity
namespace: molecular_function
def: "Enables the energy-independent facilitated diffusion, mediated by passage of proteins through a transmembrane aqueous pore or channel." [GOC:rb]
is_a: GO:0008320 ! protein transmembrane transporter activity
is_a: GO:0015267 ! channel activity

[Term]
id: GO:0015267
name: channel activity
namespace: molecular_function
alt_id: GO:0015249
alt_id: GO:0015268
def: "Enables the energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules." [GOC:mtg_transport, ISBN:0815340729, TC:1.-.-.-.-]
subset: gosubset_prok
synonym: "alpha-type channel activity" RELATED []
synonym: "channel-forming toxin activity" RELATED []
synonym: "channel/pore class transporter activity" EXACT []
synonym: "nonselective channel activity" EXACT []
synonym: "pore activity" BROAD []
synonym: "pore class transporter activity" RELATED []
xref: TC:1
is_a: GO:0022803 ! passive transmembrane transporter activity

[Term]
id: GO:0015269
name: calcium-activated potassium channel activity
namespace: molecular_function
def: "Enables the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient." [GOC:dph, GOC:mtg_transport]
subset: gosubset_prok
is_a: GO:0005227 ! calcium activated cation channel activity
is_a: GO:0005267 ! potassium channel activity

[Term]
id: GO:0015271
name: outward rectifier potassium channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel. An outwardly rectifying current-voltage relation is one where at any given driving force the outward flow of K+ ions exceeds the inward flow for the opposite driving force." [GOC:mah]
is_a: GO:0005249 ! voltage-gated potassium channel activity

[Term]
id: GO:0015272
name: ATP-activated inward rectifier potassium channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by ATP. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force." [GOC:cb, GOC:mah]
is_a: GO:0005242 ! inward rectifier potassium channel activity

[Term]
id: GO:0015274
name: organellar voltage-gated chloride channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. The membrane is an organellar membrane." [GOC:mtg_transport, ISBN:0815340729]
synonym: "organellar voltage gated chloride channel activity" EXACT []
synonym: "organellar voltage-dependent chloride channel activity" EXACT []
is_a: GO:0005247 ! voltage-gated chloride channel activity

[Term]
id: GO:0015275
name: stretch-activated, cation-selective, calcium channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a calcium ion by a channel that opens in response to a mechanical stress in the form of stretching." [GOC:mtg_transport]
is_a: GO:0005262 ! calcium channel activity
is_a: GO:0008381 ! mechanically-gated ion channel activity

[Term]
id: GO:0015276
name: ligand-gated ion channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "ionotropic receptor activity" NARROW [GOC:bf, GOC:sart]
xref: Reactome:REACT_21274 "Activation of Edited Kainate receptors, Homo sapiens"
xref: Reactome:REACT_21414 "Activation of Ca-permeable Kainate receptors, Homo sapiens"
xref: Reactome:REACT_22243 "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors, Homo sapiens"
xref: Reactome:REACT_22354 "Activation of highly calcium permeable nicotinic acetylcholine receptors, Homo sapiens"
xref: Reactome:REACT_22390 "Activation of highly sodium permeable nicotinic acetylcholine receptors, Homo sapiens"
is_a: GO:0005216 ! ion channel activity
is_a: GO:0022834 ! ligand-gated channel activity

[Term]
id: GO:0015277
name: kainate selective glutamate receptor activity
namespace: molecular_function
def: "An ionotropic glutamate receptor activity that exhibits fast gating by glutamate, acts by opening a cation channel permeable to sodium and potassium, and for which kainate is an agonist." [GOC:mah, PMID:10049997, PMID:8804111]
comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'ionotropic glutamate receptor activity ; GO:0004970' and 'cation channel activity ; GO:0005261'.
is_a: GO:0004970 ! ionotropic glutamate receptor activity

[Term]
id: GO:0015278
name: calcium-release channel activity
namespace: molecular_function
alt_id: GO:0005218
def: "Enables the transmembrane transfer of a calcium ion from intracellular stores by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mah]
synonym: "intracellular ligand-gated calcium channel activity" RELATED [GO:0015278]
is_a: GO:0005057 ! receptor signaling protein activity
is_a: GO:0005217 ! intracellular ligand-gated ion channel activity
is_a: GO:0099604 ! ligand-gated calcium channel activity
relationship: part_of GO:0051209 ! release of sequestered calcium ion into cytosol

[Term]
id: GO:0015279
name: store-operated calcium channel activity
namespace: molecular_function
def: "A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores." [GOC:dph, GOC:tb, PMID:15788710]
xref: Reactome:REACT_102930 "Calcium influx via CRAC, Sus scrofa"
xref: Reactome:REACT_103756 "Calcium influx via CRAC, Canis familiaris"
xref: Reactome:REACT_105523 "Calcium influx via CRAC, Mus musculus"
xref: Reactome:REACT_106244 "Calcium influx via CRAC, Danio rerio"
xref: Reactome:REACT_23932 "Calcium influx via CRAC, Drosophila melanogaster"
xref: Reactome:REACT_23967 "Calcium influx via CRAC, Homo sapiens"
xref: Reactome:REACT_77642 "Calcium influx via CRAC, Gallus gallus"
xref: Reactome:REACT_88934 "Calcium influx via CRAC, Caenorhabditis elegans"
xref: Reactome:REACT_89470 "Calcium influx via CRAC, Taeniopygia guttata"
xref: Reactome:REACT_90353 "Calcium influx via CRAC, Rattus norvegicus"
xref: Reactome:REACT_91451 "Calcium influx via CRAC, Xenopus tropicalis"
xref: Reactome:REACT_98130 "Calcium influx via CRAC, Bos taurus"
is_a: GO:0005262 ! calcium channel activity

[Term]
id: GO:0015280
name: ligand-gated sodium channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a sodium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mah]
synonym: "acid-sensing ion channel activity" NARROW [GOC:fj]
synonym: "amiloride-sensitive sodium channel activity" NARROW [GOC:fj]
synonym: "ASIC activity" NARROW [GOC:fj]
synonym: "epithelial sodium channel" NARROW [GOC:fj]
is_a: GO:0005272 ! sodium channel activity
is_a: GO:0015276 ! ligand-gated ion channel activity

[Term]
id: GO:0015282
name: obsolete NADPH oxidase-associated cytochrome b558 hydrogen channel activity
namespace: molecular_function
def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729]
comment: This term was made obsolete because it describes a gene product rather than a function.
synonym: "NADPH oxidase-associated cytochrome b558 hydrogen channel activity" EXACT []
synonym: "NADPH oxidase-associated cytochrome b558 proton channel" EXACT []
is_obsolete: true

[Term]
id: GO:0015283
name: obsolete apoptogenic cytochrome c release channel activity
namespace: molecular_function
def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729]
comment: This term was made obsolete because it represents a gene product.
synonym: "apoptogenic cytochrome c release channel activity" EXACT []
synonym: "Bcl-2" NARROW []
is_obsolete: true

[Term]
id: GO:0015284
name: fructose uniporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: fructose(out) = fructose(in)." [TC:2.A.1.1.13]
is_a: GO:0005353 ! fructose transmembrane transporter activity
is_a: GO:0008516 ! hexose uniporter activity

[Term]
id: GO:0015288
name: porin activity
namespace: molecular_function
def: "Catalysis of the transfer of substances, sized less than 1000 Da, from one side of the membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820, TC:1.B.1.-.-]
subset: gosubset_prok
synonym: "outer membrane exporter porin" NARROW []
synonym: "porin" EXACT []
xref: Wikipedia:Porin_(protein)
is_a: GO:0022829 ! wide pore channel activity

[Term]
id: GO:0015289
name: obsolete pore-forming toxin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the transport of electrolytes and other small molecules across a cell membrane. They are synthesized by one cell and secreted for insertion into the membrane of another cell where they form transmembrane pores. They may exert their toxic effects by allowing the free flow of electrolytes and other small molecules across the membrane, or they may allow entry into the target cell cytoplasm of a toxin protein that ultimately kills the cell." [PMID:10839820]
comment: This term was made obsolete because it represents a class of gene products.
synonym: "pore-forming toxin activity" EXACT []
is_obsolete: true
consider: GO:0005198
consider: GO:0009405
consider: GO:0046930
consider: GO:0046931
consider: GO:0050827

[Term]
id: GO:0015291
name: secondary active transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015290
alt_id: GO:0015353
alt_id: GO:0015404
alt_id: GO:0015570
def: "Catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy, not direct ATP coupling. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729, PMID:10839820]
subset: gosubset_prok
synonym: "active transporter" BROAD []
synonym: "coupled carrier" EXACT []
synonym: "electrochemical potential-driven transporter activity" EXACT []
synonym: "energizer of outer membrane receptor-mediated transport activity" NARROW []
synonym: "galactose/glucose (methylgalactoside) porter activity" RELATED []
synonym: "heavy metal ion porter activity" NARROW []
synonym: "ion-gradient-driven energizer activity" NARROW []
synonym: "multidrug endosomal transmembrane transporter activity" NARROW []
synonym: "nitrite/nitrate porter activity" NARROW []
synonym: "porter activity" EXACT []
synonym: "porters" EXACT []
synonym: "secondary carrier-type facilitators" EXACT []
xref: Reactome:REACT_103382 "CoA transport across the inner mitochondrial membrane, Dictyostelium discoideum"
xref: Reactome:REACT_104654 "CoA transport across the inner mitochondrial membrane, Mus musculus"
xref: Reactome:REACT_105273 "CoA transport across the inner mitochondrial membrane, Schizosaccharomyces pombe"
xref: Reactome:REACT_105531 "CoA transport across the inner mitochondrial membrane, Saccharomyces cerevisiae"
xref: Reactome:REACT_105779 "CoA transport across the inner mitochondrial membrane, Danio rerio"
xref: Reactome:REACT_110806 "CoA transport across the inner mitochondrial membrane, Sus scrofa"
xref: Reactome:REACT_11209 "CoA transport across the inner mitochondrial membrane, Homo sapiens"
xref: Reactome:REACT_113603 "CoA transport across the inner mitochondrial membrane, Xenopus tropicalis"
xref: Reactome:REACT_114125 "CoA transport across the inner mitochondrial membrane, Oryza sativa"
xref: Reactome:REACT_114308 "CoA transport across the inner mitochondrial membrane, Arabidopsis thaliana"
xref: Reactome:REACT_31262 "CoA transport across the inner mitochondrial membrane, Rattus norvegicus"
xref: Reactome:REACT_86944 "CoA transport across the inner mitochondrial membrane, Gallus gallus"
xref: Reactome:REACT_91139 "CoA transport across the inner mitochondrial membrane, Bos taurus"
xref: Reactome:REACT_94332 "CoA transport across the inner mitochondrial membrane, Taeniopygia guttata"
xref: Reactome:REACT_99923 "CoA transport across the inner mitochondrial membrane, Canis familiaris"
xref: TC:2.A
is_a: GO:0022804 ! active transmembrane transporter activity

[Term]
id: GO:0015292
name: uniporter activity
namespace: molecular_function
def: "Catalysis of the transport of a single molecular species across a membrane; transport is independent of the movement of any other molecular species." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]
subset: gosubset_prok
synonym: "facilitated diffusion carrier" EXACT []
synonym: "single-species transporter activity" EXACT []
synonym: "uniport" RELATED []
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0015293
name: symporter activity
namespace: molecular_function
def: "Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]
subset: gosubset_prok
synonym: "cotransporter activity" BROAD []
synonym: "porter activity" BROAD []
synonym: "symport" RELATED []
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0015294
name: solute:cation symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(out) = solute(in) + cation(in)." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008324 ! cation transmembrane transporter activity
is_a: GO:0015293 ! symporter activity

[Term]
id: GO:0015295
name: solute:proton symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(out) = solute(in) + H+(in)." [GOC:ai]
subset: gosubset_prok
synonym: "heavy metal ion:hydrogen symporter activity" NARROW []
synonym: "high affinity metal ion uptake transporter activity" NARROW []
synonym: "L-idonate/D-gluconate:hydrogen symporter activity" NARROW []
synonym: "low affinity metal ion uptake transporter activity" NARROW []
synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" NARROW []
synonym: "solute:hydrogen symporter activity" EXACT []
is_a: GO:0015294 ! solute:cation symporter activity
relationship: part_of GO:0015992 ! proton transport

[Term]
id: GO:0015296
name: anion:cation symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion(out) + cation(out) = anion(in) + cation(in)." [TC:2.A.1.14.-]
subset: gosubset_prok
is_a: GO:0008509 ! anion transmembrane transporter activity
is_a: GO:0015294 ! solute:cation symporter activity
is_a: GO:0022853 ! active ion transmembrane transporter activity

[Term]
id: GO:0015297
name: antiporter activity
namespace: molecular_function
alt_id: GO:0015300
def: "Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out)." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]
subset: gosubset_prok
synonym: "antiport" RELATED []
synonym: "countertransporter activity" EXACT []
synonym: "exchange transporter activity" EXACT []
synonym: "exchanger" BROAD []
synonym: "porter" BROAD []
synonym: "solute:solute antiporter activity" EXACT []
synonym: "solute:solute exchange" RELATED []
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0015298
name: solute:cation antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(in) = solute(in) + cation(out)." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008324 ! cation transmembrane transporter activity
is_a: GO:0015297 ! antiporter activity

[Term]
id: GO:0015299
name: solute:proton antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out)." [GOC:ai]
subset: gosubset_prok
synonym: "L-arabinose/beta-D-thiogalactopyranoside:hydrogen antiporter activity" NARROW []
synonym: "solute:hydrogen antiporter activity" EXACT []
is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity
is_a: GO:0015298 ! solute:cation antiporter activity

[Term]
id: GO:0015301
name: anion:anion antiporter activity
namespace: molecular_function
alt_id: GO:0015380
alt_id: GO:0015384
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion A(out) + anion B(in) = anion A(in) + anion B(out)." [GOC:ai, GOC:mtg_transport]
subset: gosubset_prok
synonym: "anion exchanger activity" EXACT []
synonym: "bicarbonate:chloride antiporter" NARROW []
xref: Reactome:REACT_22250 "OAT1-3 transport organic anions with antiport of dicarboxylic acids, Homo sapiens"
is_a: GO:0008509 ! anion transmembrane transporter activity
is_a: GO:0099516 ! ion antiporter activity

[Term]
id: GO:0015303
name: obsolete galactose, glucose uniporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: galactose or glucose(out) = galactose or glucose(in)." [TC:2.A.1.1.6]
comment: This term was made obsolete because it represents two molecular functions.
synonym: "galactose, glucose uniporter activity" EXACT []
is_obsolete: true
consider: GO:0015304
consider: GO:0050782

[Term]
id: GO:0015304
name: glucose uniporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) = glucose(in)." [TC:2.A.1.1.12, TC:2.A.1.1.4, TC:2.A.1.1.6]
synonym: "galactose, glucose uniporter activity" NARROW []
is_a: GO:0005355 ! glucose transmembrane transporter activity
is_a: GO:0008516 ! hexose uniporter activity

[Term]
id: GO:0015305
name: obsolete lactose, galactose:proton symporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (lactose or galactose)(out) + H+(out) = (lactose or galactose)(in) + H+(in)." [TC:2.A.1.1.9]
comment: This term was made obsolete because it represents two molecular functions.
synonym: "lactose, galactose:hydrogen symporter activity" EXACT []
synonym: "lactose, galactose:proton symporter activity" EXACT []
synonym: "lactose,galactose:proton symporter activity" EXACT []
is_obsolete: true
consider: GO:0015517
consider: GO:0015528

[Term]
id: GO:0015306
name: sialate:cation symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sialate(out) + cation(out) = sialate(in) + cation(in)." [TC:2.A.1.14.10]
synonym: "cation/sialate symporter activity" EXACT []
synonym: "cation:sialate symporter activity" EXACT []
synonym: "sialate transporter activity" BROAD []
synonym: "sialate/cation symporter activity" EXACT []
is_a: GO:0005402 ! cation:sugar symporter activity
is_a: GO:0015136 ! sialic acid transmembrane transporter activity
is_a: GO:0015296 ! anion:cation symporter activity

[Term]
id: GO:0015307
name: drug:proton antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + drug(in) = H+(in) + drug(out)." [TC:2.A.1.2.-, TC:2.A.1.3.-]
subset: gosubset_prok
synonym: "carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity" NARROW []
synonym: "drug:hydrogen antiporter activity" EXACT []
xref: Reactome:REACT_111016 "MATEs mediate extrusion of xenobiotics, Gallus gallus"
xref: Reactome:REACT_112833 "MATEs mediate extrusion of xenobiotics, Escherichia coli"
xref: Reactome:REACT_113029 "MATEs mediate extrusion of xenobiotics, Schizosaccharomyces pombe"
xref: Reactome:REACT_113149 "MATEs mediate extrusion of xenobiotics, Saccharomyces cerevisiae"
xref: Reactome:REACT_113868 "MATEs mediate extrusion of xenobiotics, Oryza sativa"
xref: Reactome:REACT_114597 "MATEs mediate extrusion of xenobiotics, Dictyostelium discoideum"
xref: Reactome:REACT_114825 "MATEs mediate extrusion of xenobiotics, Arabidopsis thaliana"
xref: Reactome:REACT_20650 "MATEs mediate extrusion of xenobiotics, Homo sapiens"
xref: Reactome:REACT_22432 "ORCTL2 mediates the transport of chloroquine and quinidine with efflux of protons, Homo sapiens"
xref: Reactome:REACT_28224 "MATEs mediate extrusion of xenobiotics, Rattus norvegicus"
xref: Reactome:REACT_34611 "MATEs mediate extrusion of xenobiotics, Xenopus tropicalis"
xref: Reactome:REACT_78270 "MATEs mediate extrusion of xenobiotics, Mus musculus"
xref: Reactome:REACT_81305 "MATEs mediate extrusion of xenobiotics, Sus scrofa"
xref: Reactome:REACT_85641 "MATEs mediate extrusion of xenobiotics, Danio rerio"
xref: Reactome:REACT_91140 "MATEs mediate extrusion of xenobiotics, Bos taurus"
xref: Reactome:REACT_96216 "MATEs mediate extrusion of xenobiotics, Canis familiaris"
is_a: GO:0015238 ! drug transmembrane transporter activity
is_a: GO:0015299 ! solute:proton antiporter activity
relationship: part_of GO:0046618 ! drug export

[Term]
id: GO:0015308
name: amiloride:proton antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + amiloride(in) = H+(in) + amiloride(out)." [TC:2.A.1.2.1]
synonym: "amiloride:hydrogen antiporter activity" EXACT []
is_a: GO:0015240 ! amiloride transporter activity
is_a: GO:0015307 ! drug:proton antiporter activity
is_a: GO:0042887 ! amide transmembrane transporter activity

[Term]
id: GO:0015309
name: cycloheximide:proton antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + cycloheximide(in) = H+(in) + cycloheximide(out)." [TC:2.A.1.2.2]
synonym: "cycloheximide:hydrogen antiporter activity" EXACT []
is_a: GO:0015243 ! cycloheximide transporter activity
is_a: GO:0015307 ! drug:proton antiporter activity
is_a: GO:0015665 ! alcohol transmembrane transporter activity
is_a: GO:0042887 ! amide transmembrane transporter activity

[Term]
id: GO:0015310
name: benomyl:proton antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + benomyl(in) = H+(in) + benomyl(out)." [TC:2.A.1.2.6]
synonym: "benomyl:hydrogen antiporter activity" EXACT []
is_a: GO:0015307 ! drug:proton antiporter activity
is_a: GO:1901479 ! benomyl transmembrane transporter activity

[Term]
id: GO:0015311
name: monoamine:proton antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + monoamine(in) = H+(in) + monoamine(out)." [TC:2.A.1.2.11, TC:2.A.1.2.12]
synonym: "monoamine:hydrogen antiporter activity" EXACT []
is_a: GO:0008504 ! monoamine transmembrane transporter activity
is_a: GO:0015299 ! solute:proton antiporter activity

[Term]
id: GO:0015312
name: polyamine:proton antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + polyamine(in) = H+(in) + polyamine(out)." [TC:2.A.1.2.16]
synonym: "polyamine:hydrogen antiporter activity" EXACT []
is_a: GO:0015203 ! polyamine transmembrane transporter activity
is_a: GO:0015299 ! solute:proton antiporter activity

[Term]
id: GO:0015313
name: fluconazole:proton antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + fluconazole(in) = H+(in) + fluconazole(out)." [TC:2.A.1.2.17]
synonym: "fluconazole:hydrogen antiporter activity" EXACT []
is_a: GO:0015244 ! fluconazole transporter activity
is_a: GO:0015665 ! alcohol transmembrane transporter activity
is_a: GO:0045119 ! azole:proton antiporter activity

[Term]
id: GO:0015314
name: aminotriazole:proton antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + aminotriazole(in) = H+(in) + aminotriazole(out)." [TC:2.A.1.3.1]
synonym: "aminotriazole:hydrogen antiporter activity" EXACT []
is_a: GO:0045119 ! azole:proton antiporter activity
is_a: GO:1901478 ! aminotriazole transmembrane transporter activity

[Term]
id: GO:0015315
name: organophosphate:inorganic phosphate antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organophosphate(out) + inorganic phosphate(in) = organophosphate(in) + inorganic phosphate(out)." [TC:2.A.1.4.-]
is_a: GO:0015114 ! phosphate ion transmembrane transporter activity
is_a: GO:0015301 ! anion:anion antiporter activity

[Term]
id: GO:0015316
name: obsolete nitrite/nitrate porter activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "nitrite/nitrate porter activity" EXACT []
is_obsolete: true
consider: GO:0015112
consider: GO:0015113
consider: GO:0015291

[Term]
id: GO:0015317
name: phosphate:proton symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phosphate(out) + H+(out) = phosphate(in) + H+(in)." [TC:2.A.1.9.-]
synonym: "phosphate:hydrogen symporter activity" EXACT []
is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity
is_a: GO:0015114 ! phosphate ion transmembrane transporter activity
is_a: GO:0015295 ! solute:proton symporter activity
is_a: GO:0015296 ! anion:cation symporter activity
is_a: GO:1901677 ! phosphate transmembrane transporter activity

[Term]
id: GO:0015318
name: inorganic solute uptake transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of an inorganic solute from the outside of a cell to the inside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729]
synonym: "inorganic uptake permease activity" EXACT []
is_a: GO:0015114 ! phosphate ion transmembrane transporter activity
is_a: GO:0015563 ! uptake transmembrane transporter activity

[Term]
id: GO:0015319
name: sodium:inorganic phosphate symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + inorganic phosphate(out) = Na+(in) + inorganic phosphate(in)." [TC:2.A.1.14.6]
is_a: GO:0005436 ! sodium:phosphate symporter activity

[Term]
id: GO:0015320
name: phosphate ion carrier activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phosphate (cyt) + H+ (cyt) = phosphate (mitochondrion) + H+ (mitochondrion)." [GOC:curators, TC:2.A.29.4.1]
is_a: GO:0015114 ! phosphate ion transmembrane transporter activity

[Term]
id: GO:0015321
name: sodium-dependent phosphate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other, requiring sodium ions." [GOC:jl]
subset: gosubset_prok
xref: Reactome:REACT_100257 "Electrogenic Na+/Pi cotransport, Staphylococcus aureus N315"
xref: Reactome:REACT_103554 "Electrogenic Na+/Pi cotransport, Sus scrofa"
xref: Reactome:REACT_104852 "Electrogenic Na+/Pi cotransport, Danio rerio"
xref: Reactome:REACT_105766 "Type III Na+/Pi cotransport, Xenopus tropicalis"
xref: Reactome:REACT_106710 "Type III Na+/Pi cotransport, Taeniopygia guttata"
xref: Reactome:REACT_108203 "Type III Na+/Pi cotransport, Sus scrofa"
xref: Reactome:REACT_110293 "Electrogenic Na+/Pi cotransport, Gallus gallus"
xref: Reactome:REACT_110985 "Electroneutral Na+/Pi cotransport, Canis familiaris"
xref: Reactome:REACT_112119 "Type I Na+-coupled phosphate co-transport, Oryza sativa"
xref: Reactome:REACT_112519 "Electroneutral Na+/Pi cotransport, Escherichia coli"
xref: Reactome:REACT_113455 "Electrogenic Na+/Pi cotransport, Escherichia coli"
xref: Reactome:REACT_113983 "Type I Na+-coupled phosphate co-transport, Staphylococcus aureus N315"
xref: Reactome:REACT_114049 "Type I Na+-coupled phosphate co-transport, Escherichia coli"
xref: Reactome:REACT_114542 "Type I Na+-coupled phosphate co-transport, Arabidopsis thaliana"
xref: Reactome:REACT_114838 "Type III Na+/Pi cotransport, Mycobacterium tuberculosis"
xref: Reactome:REACT_115481 "Type I Na+-coupled phosphate co-transport, Caenorhabditis elegans"
xref: Reactome:REACT_19133 "Electrogenic Na+/Pi cotransport, Homo sapiens"
xref: Reactome:REACT_19157 "Type I Na+-coupled phosphate co-transport, Homo sapiens"
xref: Reactome:REACT_19211 "Electroneutral Na+/Pi cotransport, Homo sapiens"
xref: Reactome:REACT_19410 "Type III Na+/Pi cotransport, Homo sapiens"
xref: Reactome:REACT_28996 "Electroneutral Na+/Pi cotransport, Staphylococcus aureus N315"
xref: Reactome:REACT_29923 "Type III Na+/Pi cotransport, Mus musculus"
xref: Reactome:REACT_30898 "Type III Na+/Pi cotransport, Bos taurus"
xref: Reactome:REACT_31130 "Electroneutral Na+/Pi cotransport, Xenopus tropicalis"
xref: Reactome:REACT_31257 "Type III Na+/Pi cotransport, Gallus gallus"
xref: Reactome:REACT_31849 "Electroneutral Na+/Pi cotransport, Sus scrofa"
xref: Reactome:REACT_32165 "Electroneutral Na+/Pi cotransport, Rattus norvegicus"
xref: Reactome:REACT_32560 "Electrogenic Na+/Pi cotransport, Taeniopygia guttata"
xref: Reactome:REACT_33976 "Type I Na+-coupled phosphate co-transport, Bos taurus"
xref: Reactome:REACT_77081 "Type III Na+/Pi cotransport, Rattus norvegicus"
xref: Reactome:REACT_78739 "Type I Na+-coupled phosphate co-transport, Mus musculus"
xref: Reactome:REACT_80886 "Type I Na+-coupled phosphate co-transport, Canis familiaris"
xref: Reactome:REACT_81175 "Electrogenic Na+/Pi cotransport, Xenopus tropicalis"
xref: Reactome:REACT_83471 "Electrogenic Na+/Pi cotransport, Canis familiaris"
xref: Reactome:REACT_83775 "Electroneutral Na+/Pi cotransport, Mus musculus"
xref: Reactome:REACT_85502 "Electrogenic Na+/Pi cotransport, Mus musculus"
xref: Reactome:REACT_85878 "Type III Na+/Pi cotransport, Plasmodium falciparum"
xref: Reactome:REACT_86179 "Type III Na+/Pi cotransport, Canis familiaris"
xref: Reactome:REACT_88271 "Type III Na+/Pi cotransport, Danio rerio"
xref: Reactome:REACT_89710 "Electrogenic Na+/Pi cotransport, Rattus norvegicus"
xref: Reactome:REACT_89864 "Type III Na+/Pi cotransport, Drosophila melanogaster"
xref: Reactome:REACT_94572 "Type III Na+/Pi cotransport, Saccharomyces cerevisiae"
xref: Reactome:REACT_95135 "Type I Na+-coupled phosphate co-transport, Danio rerio"
xref: Reactome:REACT_98218 "Type I Na+-coupled phosphate co-transport, Sus scrofa"
xref: Reactome:REACT_98398 "Electrogenic Na+/Pi cotransport, Bos taurus"
is_a: GO:0015114 ! phosphate ion transmembrane transporter activity
relationship: part_of GO:0044341 ! sodium-dependent phosphate transport

[Term]
id: GO:0015322
name: secondary active oligopeptide transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of an oligopeptide or oligopeptides from one side of the membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport]
subset: gosubset_prok
synonym: "oligopeptide porter activity" RELATED []
is_a: GO:0015291 ! secondary active transmembrane transporter activity
is_a: GO:0035673 ! oligopeptide transmembrane transporter activity

[Term]
id: GO:0015323
name: obsolete type V protein secretor activity
namespace: molecular_function
def: "OBSOLETE." [GOC:mtg_transport]
comment: This term was made obsolete because it does not accurately reflect the function of the proteins involved.
synonym: "type V protein secretor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0015324
name: peptide-acetyl-CoA secondary active transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of peptide-acetyl-CoA from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport]
synonym: "peptide-acetyl-CoA transporter activity" RELATED []
is_a: GO:0015291 ! secondary active transmembrane transporter activity
is_a: GO:1904680 ! peptide transmembrane transporter activity

[Term]
id: GO:0015325
name: acetyl-CoA:CoA antiporter activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA(out) + CoA(in) = acetyl-CoA(in) + CoA(out)." [TC:2.A.1.25.1]
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0008521 ! acetyl-CoA transporter activity
is_a: GO:0015297 ! antiporter activity
is_a: GO:0015324 ! peptide-acetyl-CoA secondary active transmembrane transporter activity
is_a: GO:1901682 ! sulfur compound transmembrane transporter activity

[Term]
id: GO:0015327
name: cystine:glutamate antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cystine(out) + glutamate(in) = cystine(in) + glutamate(out)." [TC:2.A.3.8.5]
is_a: GO:0005313 ! L-glutamate transmembrane transporter activity
is_a: GO:0015301 ! anion:anion antiporter activity
is_a: GO:0015328 ! cystine secondary active transmembrane transporter activity

[Term]
id: GO:0015328
name: cystine secondary active transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of cystine from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport]
synonym: "cystine porter activity" RELATED []
synonym: "cystinosin" NARROW []
synonym: "lysosomal cystine transporter" NARROW []
is_a: GO:0005294 ! neutral L-amino acid secondary active transmembrane transporter activity
is_a: GO:0072349 ! modified amino acid transmembrane transporter activity
is_a: GO:1901680 ! sulfur-containing amino acid secondary active transmembrane transporter activity

[Term]
id: GO:0015330
name: high-affinity glutamine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the high affinity transfer of glutamine from one side of the membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport]
synonym: "high affinity glutamine permease activity" RELATED []
synonym: "high affinity glutamine transmembrane transporter activity" EXACT []
is_a: GO:0005287 ! high-affinity basic amino acid transmembrane transporter activity
is_a: GO:0015186 ! L-glutamine transmembrane transporter activity

[Term]
id: GO:0015331
name: obsolete asparagine/glutamine permease activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the stereospecific transfer of asparagine or glutamine across a biological membrane." [GOC:ai]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "asparagine/glutamine permease activity" EXACT []
is_obsolete: true
consider: GO:0015182
consider: GO:0015186
consider: GO:0022857

[Term]
id: GO:0015332
name: obsolete leucine/valine/isoleucine permease activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "leucine/valine/isoleucine permease activity" EXACT []
is_obsolete: true
consider: GO:0005304
consider: GO:0015188
consider: GO:0015190
consider: GO:0022857

[Term]
id: GO:0015333
name: peptide:proton symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: peptide(out) + H+(out) = peptide(in) + H+(in). Catalysis of the transfer of a peptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by hydrogen ion movement." [GOC:mtg_transport, TC:2.A.17.-.-]
subset: gosubset_prok
synonym: "peptide:hydrogen symporter activity" EXACT []
xref: Reactome:REACT_101095 "Proton-coupled di- and tri-peptide cotransport, Mus musculus"
xref: Reactome:REACT_102202 "Proton-coupled histidine and di-peptide cotransport, Mus musculus"
xref: Reactome:REACT_103350 "Proton-coupled di- and tri-peptide cotransport, Danio rerio"
xref: Reactome:REACT_105508 "Proton-coupled histidine and di-peptide cotransport, Danio rerio"
xref: Reactome:REACT_108042 "Proton-coupled histidine and di-peptide cotransport, Canis familiaris"
xref: Reactome:REACT_110500 "Proton-coupled di- and tri-peptide cotransport, Canis familiaris"
xref: Reactome:REACT_111949 "Proton-coupled histidine and di-peptide cotransport, Saccharomyces cerevisiae"
xref: Reactome:REACT_114016 "Proton-coupled di- and tri-peptide cotransport, Caenorhabditis elegans"
xref: Reactome:REACT_115385 "Proton-coupled histidine and di-peptide cotransport, Schizosaccharomyces pombe"
xref: Reactome:REACT_19313 "Proton-coupled di- and tri-peptide cotransport, Homo sapiens"
xref: Reactome:REACT_19377 "Proton-coupled histidine and di-peptide cotransport, Homo sapiens"
xref: Reactome:REACT_28501 "Proton-coupled di- and tri-peptide cotransport, Drosophila melanogaster"
xref: Reactome:REACT_28981 "Proton-coupled histidine and di-peptide cotransport, Bos taurus"
xref: Reactome:REACT_29163 "Proton-coupled di- and tri-peptide cotransport, Gallus gallus"
xref: Reactome:REACT_29291 "Proton-coupled di- and tri-peptide cotransport, Xenopus tropicalis"
xref: Reactome:REACT_30629 "Proton-coupled di- and tri-peptide cotransport, Bos taurus"
xref: Reactome:REACT_32162 "Proton-coupled histidine and di-peptide cotransport, Arabidopsis thaliana"
xref: Reactome:REACT_32459 "Proton-coupled histidine and di-peptide cotransport, Rattus norvegicus"
xref: Reactome:REACT_80116 "Proton-coupled histidine and di-peptide cotransport, Taeniopygia guttata"
xref: Reactome:REACT_81053 "Proton-coupled di- and tri-peptide cotransport, Sus scrofa"
xref: Reactome:REACT_81800 "Proton-coupled histidine and di-peptide cotransport, Oryza sativa"
xref: Reactome:REACT_84642 "Proton-coupled di- and tri-peptide cotransport, Taeniopygia guttata"
xref: Reactome:REACT_86326 "Proton-coupled histidine and di-peptide cotransport, Gallus gallus"
xref: Reactome:REACT_88544 "Proton-coupled di- and tri-peptide cotransport, Rattus norvegicus"
xref: Reactome:REACT_92332 "Proton-coupled di- and tri-peptide cotransport, Dictyostelium discoideum"
xref: Reactome:REACT_93541 "Proton-coupled histidine and di-peptide cotransport, Xenopus tropicalis"
xref: Reactome:REACT_96620 "Proton-coupled histidine and di-peptide cotransport, Sus scrofa"
is_a: GO:0015295 ! solute:proton symporter activity
is_a: GO:0022897 ! proton-dependent peptide secondary active transmembrane transporter activity

[Term]
id: GO:0015334
name: high-affinity oligopeptide transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of oligopeptide from one side of the membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [GOC:mtg_transport]
synonym: "high affinity oligopeptide transporter activity" EXACT []
is_a: GO:0015198 ! oligopeptide transporter activity

[Term]
id: GO:0015335
name: obsolete heavy metal ion:hydrogen symporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: Me2+(out) + H+(out) = Me2+(in) + H+(in), where Me2+ is Fe2+, Zn2+, Mn2+, Cu2+, Cd2+, Co2+, Ni2+ or Pb2+." [TC:2.A.55.2.1, TC:2.A.55.2.2]
comment: This term was made obsolete because it represents a gene product and not a molecular function.
synonym: "heavy metal ion:hydrogen symporter activity" EXACT []
synonym: "heavy metal ion:proton symporter activity" EXACT []
is_obsolete: true
consider: GO:0015295
consider: GO:0046873

[Term]
id: GO:0015336
name: obsolete high affinity metal ion uptake transporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: Me2+(out) + H+(out) = Me2+(in) + H+(in). Me can be Fe2+, Mn2+, Zn2+, Cu2+, Cd2+, Ni2+ or Co2+." [TC:2.A.55.1.1]
comment: This term was made obsolete because it represents a gene product and not a molecular function.
synonym: "high affinity metal ion uptake transporter activity" EXACT []
is_obsolete: true
consider: GO:0015295
consider: GO:0046873

[Term]
id: GO:0015337
name: obsolete low affinity metal ion uptake transporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: Me2+(out) + H+(out) = Me2+(in) + H+(in). Me can be Mn2+ or Cu2+." [TC:2.A.55.1.2]
comment: This term was made obsolete because it represents a gene product and not a molecular function.
synonym: "low affinity metal ion uptake transporter activity" EXACT []
is_obsolete: true
consider: GO:0015295
consider: GO:0046873

[Term]
id: GO:0015339
name: obsolete cobalt, zinc uptake permease activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (Zn2+ or Co2+)(out) = (Zn2+ or Co2+)(in). The activity is driven by proton motive force, possibly by proton symport." [TC:2.A.4.2.1]
comment: This term was made obsolete because it represents more than one molecular function.
synonym: "cobalt, zinc uptake permease activity" EXACT []
is_obsolete: true
consider: GO:0005385
consider: GO:0015087
consider: GO:0015563

[Term]
id: GO:0015340
name: obsolete zinc, cadmium uptake permease activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (Zn2+ or Cd2+)(out) = (Zn2+ or Cd2+)(in). The activity is driven by proton motive force, possibly by proton symport." [TC:2.A.4.2.2]
comment: This term was made obsolete because it represents more than one molecular function.
synonym: "zinc, cadmium uptake permease activity" EXACT []
is_obsolete: true
consider: GO:0005385
consider: GO:0015086
consider: GO:0015563

[Term]
id: GO:0015341
name: zinc efflux active transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a zinc ion or zinc ions from the inside of the cell to the outside of the cell across a membrane: Zn2+(out) = Zn2+(in). The activity is driven by proton motive force." [GOC:mtg_transport, ISBN:0815340729, TC:2.A.4.1.4, TC:2.A.4.2.3]
synonym: "zinc efflux permease activity" BROAD []
is_a: GO:0005261 ! cation channel activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity
is_a: GO:0022883 ! zinc efflux transmembrane transporter activity

[Term]
id: GO:0015342
name: obsolete zinc, iron permease activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (Zn2+ or Fe2+)(out) = (Zn2+ or Fe2+)(in), probably powered by proton motive force." [TC:2.A.5.-.-]
comment: This term was made obsolete because it represents more than one molecular function.
synonym: "zinc, iron permease activity" EXACT []
is_obsolete: true
consider: GO:0005381
consider: GO:0005385
consider: GO:0015563

[Term]
id: GO:0015343
name: siderophore transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015236
alt_id: GO:0015237
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(out) + H+(out) = siderophore-iron(in) + H+(in)." [TC:2.A.1.16.-]
subset: gosubset_prok
synonym: "iron-siderophore transporter activity" EXACT []
synonym: "siderochrome-iron transporter activity" NARROW []
synonym: "siderophore-iron transmembrane transporter activity" RELATED []
is_a: GO:0005381 ! iron ion transmembrane transporter activity
is_a: GO:0015603 ! iron chelate transmembrane transporter activity
is_a: GO:0042927 ! siderophore transporter activity
relationship: part_of GO:0044718 ! siderophore transmembrane transport

[Term]
id: GO:0015344
name: siderophore uptake transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(ferrioxamine)(out) + H+(out) = siderophore-iron(ferrioxamine)(in) + H+(in)." [TC:2.A.1.16.1]
synonym: "ferrioxamine uptake transmembrane transporter activity" RELATED []
synonym: "siderochrome-iron (ferrioxamine) uptake transporter" NARROW []
synonym: "siderophore-iron uptake transmembrane transporter activity" RELATED []
is_a: GO:0015343 ! siderophore transmembrane transporter activity

[Term]
id: GO:0015345
name: ferric enterobactin:proton symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ferric enterobactin(out) + H+(out) = ferric enterobactin(in) + H+(in)." [TC:2.A.1.16.2]
synonym: "ferric enterobactin:hydrogen symporter activity" EXACT []
synonym: "ferric-enterobactin:proton symporter activity" EXACT []
is_a: GO:0015295 ! solute:proton symporter activity
is_a: GO:0015620 ! ferric-enterobactin transmembrane transporter activity

[Term]
id: GO:0015346
name: ferric triacetylfusarinine C:proton symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ferric triacetylfusarinine C(out) + H+(out) = ferric triacetylfusarinine C(in) + H+(in)." [TC:2.A.1.16.3]
synonym: "ferric triacetylfusarinine C:hydrogen symporter activity" EXACT []
is_a: GO:0015295 ! solute:proton symporter activity
is_a: GO:0015343 ! siderophore transmembrane transporter activity
is_a: GO:0015621 ! ferric triacetylfusarinine C transmembrane transporter activity
relationship: part_of GO:0015686 ! ferric triacetylfusarinine C transport

[Term]
id: GO:0015347
name: sodium-independent organic anion transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of organic anions from one side of a membrane to the other, in a sodium independent manner." [GOC:go_curators]
xref: Reactome:REACT_22294 "OAT2 and OAT4 mediate transport of sulphate conjugates, Homo sapiens"
xref: Reactome:REACT_23822 "SLCO3A1 isoform 1 has abroad substrate specificity, Homo sapiens"
xref: Reactome:REACT_23829 "SLCO2B1 has a narrow substrate specificity, Homo sapiens"
xref: Reactome:REACT_23909 "SLCO4C1 mediates the transport of digoxin, Homo sapiens"
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0015348
name: obsolete prostaglandin/thromboxane transporter activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "prostaglandin/thromboxane transporter activity" EXACT []
is_obsolete: true
consider: GO:0008028
consider: GO:0015132

[Term]
id: GO:0015349
name: thyroid hormone transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of thyroid hormones from one side of the membrane to the other. Thyroid hormone are any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine." [GOC:ai]
xref: Reactome:REACT_23913 "SLCO1B1, SLCO4A1 and SLCO1C1 mediate the transport of thyroid hormones, Homo sapiens"
is_a: GO:0015291 ! secondary active transmembrane transporter activity
is_a: GO:0072349 ! modified amino acid transmembrane transporter activity
relationship: part_of GO:0070327 ! thyroid hormone transport

[Term]
id: GO:0015350
name: methotrexate transporter activity
namespace: molecular_function
def: "Enables the directed movement of methotrexate, 4-amino-10-methylformic acid, into, out of or within a cell, or between cells. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase." [GOC:ai]
is_a: GO:0090484 ! drug transporter activity
relationship: part_of GO:0051958 ! methotrexate transport

[Term]
id: GO:0015351
name: bilirubin secondary active transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of bilirubin from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport]
synonym: "bilirubin porter activity" RELATED []
synonym: "bilitranslocase" NARROW []
is_a: GO:0015127 ! bilirubin transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0015352
name: secondary active sterol transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of sterol from one side of the membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport]
synonym: "sterol porter activity" RELATED []
is_a: GO:0015248 ! sterol transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity
is_a: GO:0015665 ! alcohol transmembrane transporter activity

[Term]
id: GO:0015355
name: secondary active monocarboxylate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the movement of a monocarboxylate, any compound containing a single carboxyl group (COOH or COO-), by uniport, symport or antiport across a membrane by a carrier-mediated mechanism." [GOC:bf, GOC:jl]
synonym: "monocarboxylate porter activity" RELATED []
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0015356
name: obsolete monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity" EXACT []
is_obsolete: true
consider: GO:0015129
consider: GO:0015130
consider: GO:0015562
consider: GO:0015563
consider: GO:0050833

[Term]
id: GO:0015358
name: obsolete amino acid/choline transmembrane transporter activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "amino acid/choline transmembrane transporter activity" EXACT []
is_obsolete: true
consider: GO:0015171
consider: GO:0015220

[Term]
id: GO:0015360
name: acetate:proton symporter activity
namespace: molecular_function
alt_id: GO:0015357
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: acetate(out) + H+(out) = acetate(in) + H+(in)." [TC:2.A.44.4.1]
synonym: "acetate:hydrogen symporter activity" EXACT []
synonym: "hydrogen:acetate symporter activity" EXACT []
is_a: GO:0015295 ! solute:proton symporter activity
is_a: GO:0043893 ! acetate:cation symporter activity

[Term]
id: GO:0015361
name: low-affinity sodium:dicarboxylate symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [TC:2.A.47.1.1]
synonym: "low affinity sodium:dicarboxylate cotransporter activity" BROAD []
synonym: "low affinity sodium:dicarboxylate symporter activity" EXACT []
xref: Reactome:REACT_103980 "NaDC1 co-transports dicarboxylic acids and a sodium ion, Bos taurus"
xref: Reactome:REACT_106412 "NaDC1 co-transports dicarboxylic acids and a sodium ion, Rattus norvegicus"
xref: Reactome:REACT_107355 "NaDC1 co-transports dicarboxylic acids and a sodium ion, Canis familiaris"
xref: Reactome:REACT_107827 "NaDC1 co-transports dicarboxylic acids and a sodium ion, Taeniopygia guttata"
xref: Reactome:REACT_108326 "NaDC1 co-transports dicarboxylic acids and a sodium ion, Xenopus tropicalis"
xref: Reactome:REACT_20534 "NaDC1 co-transports dicarboxylic acids and a sodium ion, Homo sapiens"
xref: Reactome:REACT_77447 "NaDC1 co-transports dicarboxylic acids and a sodium ion, Drosophila melanogaster"
xref: Reactome:REACT_81878 "NaDC1 co-transports dicarboxylic acids and a sodium ion, Caenorhabditis elegans"
xref: Reactome:REACT_83457 "NaDC1 co-transports dicarboxylic acids and a sodium ion, Oryza sativa"
xref: Reactome:REACT_84498 "NaDC1 co-transports dicarboxylic acids and a sodium ion, Arabidopsis thaliana"
xref: Reactome:REACT_86514 "NaDC1 co-transports dicarboxylic acids and a sodium ion, Staphylococcus aureus N315"
xref: Reactome:REACT_91699 "NaDC1 co-transports dicarboxylic acids and a sodium ion, Mus musculus"
xref: Reactome:REACT_92776 "NaDC1 co-transports dicarboxylic acids and a sodium ion, Sus scrofa"
xref: Reactome:REACT_94220 "NaDC1 co-transports dicarboxylic acids and a sodium ion, Danio rerio"
xref: Reactome:REACT_95780 "NaDC1 co-transports dicarboxylic acids and a sodium ion, Gallus gallus"
is_a: GO:0017153 ! sodium:dicarboxylate symporter activity

[Term]
id: GO:0015362
name: high-affinity sodium:dicarboxylate symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [TC:2.A.47.1.4]
synonym: "high affinity sodium:dicarboxylate cotransporter activity" BROAD []
synonym: "high affinity sodium:dicarboxylate symporter activity" EXACT []
xref: Reactome:REACT_102311 "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion, Canis familiaris"
xref: Reactome:REACT_109541 "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion, Taeniopygia guttata"
xref: Reactome:REACT_110342 "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion, Gallus gallus"
xref: Reactome:REACT_20618 "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion, Homo sapiens"
xref: Reactome:REACT_28289 "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion, Arabidopsis thaliana"
xref: Reactome:REACT_33016 "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion, Oryza sativa"
xref: Reactome:REACT_81965 "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion, Rattus norvegicus"
xref: Reactome:REACT_82663 "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion, Caenorhabditis elegans"
xref: Reactome:REACT_85371 "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion, Danio rerio"
xref: Reactome:REACT_91018 "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion, Bos taurus"
xref: Reactome:REACT_92546 "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion, Staphylococcus aureus N315"
xref: Reactome:REACT_95897 "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion, Sus scrofa"
xref: Reactome:REACT_96999 "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion, Drosophila melanogaster"
xref: Reactome:REACT_97266 "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion, Mus musculus"
xref: Reactome:REACT_99470 "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion, Xenopus tropicalis"
is_a: GO:0017153 ! sodium:dicarboxylate symporter activity

[Term]
id: GO:0015363
name: obsolete dicarboxylate (succinate/fumarate/malate) antiporter activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity" EXACT []
is_obsolete: true
consider: GO:0005310
consider: GO:0015138
consider: GO:0015140
consider: GO:0015141
consider: GO:0015297

[Term]
id: GO:0015364
name: dicarboxylate:inorganic phosphate antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + inorganic phosphate(in) = dicarboxylate(in) + inorganic phosphate(out)." [TC:2.A.29.2.3]
is_a: GO:0015114 ! phosphate ion transmembrane transporter activity
is_a: GO:0015297 ! antiporter activity

[Term]
id: GO:0015366
name: malate:proton symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: malate(out) + H+(out) = malate(in) + H+(in)." [TC:2.A.16.2.1]
synonym: "L-malic acid permease" RELATED [GOC:vw]
synonym: "L-malic acid:proton symporter activity" RELATED [GOC:vw]
synonym: "malate permease" RELATED [GOC:vw]
synonym: "malate:hydrogen symporter activity" EXACT []
is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity
is_a: GO:0015140 ! malate transmembrane transporter activity
is_a: GO:0015295 ! solute:proton symporter activity
is_a: GO:0015296 ! anion:cation symporter activity

[Term]
id: GO:0015367
name: oxoglutarate:malate antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: oxoglutarate(out) + malate(in) = oxoglutarate(in) + malate(out)." [TC:2.A.29.2.1]
xref: Reactome:REACT_106628 "malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix], Taeniopygia guttata"
xref: Reactome:REACT_108451 "malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix], Canis familiaris"
xref: Reactome:REACT_109603 "malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix], Sus scrofa"
xref: Reactome:REACT_11181 "malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix], Homo sapiens"
xref: Reactome:REACT_112909 "malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix], Dictyostelium discoideum"
xref: Reactome:REACT_116091 "2-oxoglutarate [mitochondrial matrix] + malate [cytosol] <=> 2-oxoglutarate [cytosol] + malate [mitochondrial matrix], Gallus gallus"
xref: Reactome:REACT_78546 "malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix], Plasmodium falciparum"
xref: Reactome:REACT_81002 "malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix], Arabidopsis thaliana"
xref: Reactome:REACT_83200 "malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix], Danio rerio"
xref: Reactome:REACT_83598 "malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix], Rattus norvegicus"
xref: Reactome:REACT_84193 "malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix], Bos taurus"
xref: Reactome:REACT_92717 "malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix], Xenopus tropicalis"
xref: Reactome:REACT_92806 "malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix], Caenorhabditis elegans"
xref: Reactome:REACT_94424 "malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix], Mus musculus"
is_a: GO:0015140 ! malate transmembrane transporter activity
is_a: GO:0015301 ! anion:anion antiporter activity
relationship: part_of GO:0015742 ! alpha-ketoglutarate transport

[Term]
id: GO:0015368
name: calcium:cation antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + cation(out) = Ca2+(out) + cation(in)." [TC:2.A.19.-.-]
subset: gosubset_prok
xref: Reactome:REACT_100277 "K+-independent Li+/Ca2+ exchanger transport, Saccharomyces cerevisiae"
xref: Reactome:REACT_101436 "K+-independent Li+/Ca2+ exchanger transport, Drosophila melanogaster"
xref: Reactome:REACT_104836 "K+-independent Li+/Ca2+ exchanger transport, Gallus gallus"
xref: Reactome:REACT_105011 "K+-independent Li+/Ca2+ exchanger transport, Canis familiaris"
xref: Reactome:REACT_108298 "K+-independent Li+/Ca2+ exchanger transport, Bos taurus"
xref: Reactome:REACT_112998 "K+-independent Li+/Ca2+ exchanger transport, Arabidopsis thaliana"
xref: Reactome:REACT_114708 "K+-independent Li+/Ca2+ exchanger transport, Oryza sativa"
xref: Reactome:REACT_19367 "K+-independent Li+/Ca2+ exchanger transport, Homo sapiens"
xref: Reactome:REACT_28347 "K+-independent Li+/Ca2+ exchanger transport, Schizosaccharomyces pombe"
xref: Reactome:REACT_30721 "K+-independent Li+/Ca2+ exchanger transport, Xenopus tropicalis"
xref: Reactome:REACT_85112 "K+-independent Li+/Ca2+ exchanger transport, Taeniopygia guttata"
xref: Reactome:REACT_89395 "K+-independent Li+/Ca2+ exchanger transport, Sus scrofa"
xref: Reactome:REACT_92602 "K+-independent Li+/Ca2+ exchanger transport, Danio rerio"
xref: Reactome:REACT_95702 "K+-independent Li+/Ca2+ exchanger transport, Mus musculus"
xref: Reactome:REACT_95744 "K+-independent Li+/Ca2+ exchanger transport, Rattus norvegicus"
xref: Reactome:REACT_97543 "K+-independent Li+/Ca2+ exchanger transport, Caenorhabditis elegans"
is_a: GO:0015085 ! calcium ion transmembrane transporter activity
is_a: GO:0015491 ! cation:cation antiporter activity

[Term]
id: GO:0015369
name: calcium:proton antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + H+(out) = Ca2+(out) + H+(in)." [TC:2.A.19.2.-]
subset: gosubset_prok
synonym: "calcium:hydrogen antiporter activity" EXACT []
xref: RHEA:29674
is_a: GO:0015368 ! calcium:cation antiporter activity
is_a: GO:0051139 ! metal ion:proton antiporter activity

[Term]
id: GO:0015370
name: solute:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + Na+(out) = solute(in) + Na+(in)." [GOC:ai]
subset: gosubset_prok
synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" NARROW []
is_a: GO:0015081 ! sodium ion transmembrane transporter activity
is_a: GO:0015294 ! solute:cation symporter activity

[Term]
id: GO:0015371
name: galactose:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose(out) + Na+(out) = glucose(in) + Na+(in)." [TC:2.A.21.3.-]
is_a: GO:0005354 ! galactose transmembrane transporter activity
is_a: GO:0015370 ! solute:sodium symporter activity

[Term]
id: GO:0015372
name: obsolete glutamate/aspartate:sodium symporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (glutamate or aspartate)(out) + Na+(out) = (glutamate or aspartate)(in) + Na+(in)." [TC:2.A.23.1.1]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "glutamate/aspartate:sodium symporter activity" EXACT []
is_obsolete: true
consider: GO:0005283
consider: GO:0005313
consider: GO:0015183

[Term]
id: GO:0015373
name: monovalent anion:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monovalent anion(out) + Na+(out) = monovalent anion(in) + Na+(in)." [TC:2.A.21.5.-]
is_a: GO:0015296 ! anion:cation symporter activity
is_a: GO:0015370 ! solute:sodium symporter activity

[Term]
id: GO:0015374
name: neutral, basic amino acid:sodium:chloride symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral/basic amino acid(out) + Na+(out) + Cl-(out) = neutral/basic amino acid(in) + Na+(in) + Cl-(in)." [TC:2.A.22.2.3]
synonym: "neutral, cationic amino acid:sodium:chloride symporter activity" RELATED []
is_a: GO:0005283 ! sodium:amino acid symporter activity
relationship: part_of GO:0006821 ! chloride transport

[Term]
id: GO:0015375
name: glycine:sodium symporter activity
namespace: molecular_function
alt_id: GO:0015656
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine(out) + Na+(out) = glycine(in) + Na+(in)." [GOC:ai]
xref: Reactome:REACT_20620 "GLYT1/2 mediate glycine uptake, Homo sapiens"
is_a: GO:0005283 ! sodium:amino acid symporter activity
is_a: GO:0005294 ! neutral L-amino acid secondary active transmembrane transporter activity
is_a: GO:0015187 ! glycine transmembrane transporter activity
is_a: GO:0015296 ! anion:cation symporter activity

[Term]
id: GO:0015376
name: obsolete betaine/GABA:sodium symporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (betaine or gamma-aminobutyric acid)(out) + Na+(out) = (betaine or gamma-aminobutyric acid)(in) + Na+(in)." [TC:2.A.22.3.1]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "betaine/GABA:sodium symporter activity" EXACT []
is_obsolete: true
consider: GO:0005332
consider: GO:0015185
consider: GO:0015199
consider: GO:0015370

[Term]
id: GO:0015377
name: cation:chloride symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation(out) + Cl-(out) = cation(in) + Cl-(in)." [TC:2.A.30.-.-]
synonym: "cation:chloride cotransporter activity" BROAD []
is_a: GO:0015108 ! chloride transmembrane transporter activity
is_a: GO:0015296 ! anion:cation symporter activity

[Term]
id: GO:0015378
name: sodium:chloride symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + Cl-(out) = Na+(in) + Cl-(in)." [TC:2.A.30.4.-]
xref: Reactome:REACT_103742 "Na+/Cl- cotransport, Taeniopygia guttata"
xref: Reactome:REACT_104373 "Na+/Cl- cotransport, Xenopus tropicalis"
xref: Reactome:REACT_110102 "Na+/Cl- cotransport, Bos taurus"
xref: Reactome:REACT_113205 "Na+/Cl- cotransport, Drosophila melanogaster"
xref: Reactome:REACT_114168 "Na+/Cl- cotransport, Caenorhabditis elegans"
xref: Reactome:REACT_19417 "Na+/Cl- cotransport, Homo sapiens"
xref: Reactome:REACT_33300 "Na+/Cl- cotransport, Oryza sativa"
xref: Reactome:REACT_33759 "Na+/Cl- cotransport, Mus musculus"
xref: Reactome:REACT_79455 "Na+/Cl- cotransport, Gallus gallus"
xref: Reactome:REACT_79635 "Na+/Cl- cotransport, Canis familiaris"
xref: Reactome:REACT_81530 "Na+/Cl- cotransport, Danio rerio"
xref: Reactome:REACT_84870 "Na+/Cl- cotransport, Rattus norvegicus"
xref: Reactome:REACT_91428 "Na+/Cl- cotransport, Arabidopsis thaliana"
is_a: GO:0015377 ! cation:chloride symporter activity

[Term]
id: GO:0015379
name: potassium:chloride symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Cl-(out) = K+(in) + Cl-(in)." [TC:2.A.30.5.-]
xref: Reactome:REACT_102130 "K+/Cl- cotransport, Taeniopygia guttata"
xref: Reactome:REACT_103770 "K+/Cl- cotransport, Drosophila melanogaster"
xref: Reactome:REACT_114447 "K+/Cl- cotransport, Caenorhabditis elegans"
xref: Reactome:REACT_19385 "K+/Cl- cotransport, Homo sapiens"
xref: Reactome:REACT_32193 "K+/Cl- cotransport, Canis familiaris"
xref: Reactome:REACT_81745 "K+/Cl- cotransport, Sus scrofa"
xref: Reactome:REACT_83580 "K+/Cl- cotransport, Bos taurus"
xref: Reactome:REACT_86083 "K+/Cl- cotransport, Gallus gallus"
xref: Reactome:REACT_89543 "K+/Cl- cotransport, Rattus norvegicus"
xref: Reactome:REACT_89567 "K+/Cl- cotransport, Mus musculus"
xref: Reactome:REACT_91009 "K+/Cl- cotransport, Xenopus tropicalis"
xref: Reactome:REACT_98576 "K+/Cl- cotransport, Danio rerio"
is_a: GO:0015377 ! cation:chloride symporter activity

[Term]
id: GO:0015381
name: high-affinity sulfate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the secondary active high affinity transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. In high-affinity transport the transporter is able to bind thesolute even if it is only present at very low concentrations." [GOC:mtg_transport]
synonym: "high affinity sulfate permease activity" RELATED []
synonym: "high affinity sulfate transmembrane transporter activity" EXACT []
synonym: "high affinity sulphate permease activity" EXACT []
is_a: GO:0008271 ! secondary active sulfate transmembrane transporter activity

[Term]
id: GO:0015382
name: sodium:sulfate symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + Na+(out) = sulfate(in) + Na+(in)." [TC:2.A.47.1.2]
synonym: "sodium:sulfate cotransporter activity" BROAD []
synonym: "sodium:sulphate symporter activity" EXACT []
xref: Reactome:REACT_100174 "NaS1 co-transports sulphate and a sodium ion, Gallus gallus"
xref: Reactome:REACT_100363 "NaS1 co-transports sulphate and a sodium ion, Danio rerio"
xref: Reactome:REACT_104377 "NaS2 co-transports sulphate and two sodium ions, Danio rerio"
xref: Reactome:REACT_106233 "NaS2 co-transports sulphate and two sodium ions, Rattus norvegicus"
xref: Reactome:REACT_106575 "NaS1 co-transports sulphate and a sodium ion, Rattus norvegicus"
xref: Reactome:REACT_20504 "NaS1 co-transports sulphate and a sodium ion, Homo sapiens"
xref: Reactome:REACT_20550 "NaS2 co-transports sulphate and two sodium ions, Homo sapiens"
xref: Reactome:REACT_29432 "NaS2 co-transports sulphate and two sodium ions, Arabidopsis thaliana"
xref: Reactome:REACT_31995 "NaS1 co-transports sulphate and a sodium ion, Bos taurus"
xref: Reactome:REACT_32147 "NaS2 co-transports sulphate and two sodium ions, Canis familiaris"
xref: Reactome:REACT_34023 "NaS2 co-transports sulphate and two sodium ions, Oryza sativa"
xref: Reactome:REACT_80461 "NaS2 co-transports sulphate and two sodium ions, Drosophila melanogaster"
xref: Reactome:REACT_81209 "NaS1 co-transports sulphate and a sodium ion, Staphylococcus aureus N315"
xref: Reactome:REACT_81529 "NaS1 co-transports sulphate and a sodium ion, Arabidopsis thaliana"
xref: Reactome:REACT_82107 "NaS2 co-transports sulphate and two sodium ions, Sus scrofa"
xref: Reactome:REACT_82376 "NaS2 co-transports sulphate and two sodium ions, Caenorhabditis elegans"
xref: Reactome:REACT_84372 "NaS1 co-transports sulphate and a sodium ion, Sus scrofa"
xref: Reactome:REACT_84435 "NaS2 co-transports sulphate and two sodium ions, Xenopus tropicalis"
xref: Reactome:REACT_85984 "NaS1 co-transports sulphate and a sodium ion, Drosophila melanogaster"
xref: Reactome:REACT_86411 "NaS2 co-transports sulphate and two sodium ions, Mus musculus"
xref: Reactome:REACT_86766 "NaS1 co-transports sulphate and a sodium ion, Taeniopygia guttata"
xref: Reactome:REACT_87136 "NaS2 co-transports sulphate and two sodium ions, Bos taurus"
xref: Reactome:REACT_87539 "NaS1 co-transports sulphate and a sodium ion, Xenopus tropicalis"
xref: Reactome:REACT_91517 "NaS2 co-transports sulphate and two sodium ions, Taeniopygia guttata"
xref: Reactome:REACT_91935 "NaS1 co-transports sulphate and a sodium ion, Caenorhabditis elegans"
xref: Reactome:REACT_95438 "NaS2 co-transports sulphate and two sodium ions, Staphylococcus aureus N315"
xref: Reactome:REACT_96611 "NaS1 co-transports sulphate and a sodium ion, Canis familiaris"
xref: Reactome:REACT_96858 "NaS1 co-transports sulphate and a sodium ion, Oryza sativa"
xref: Reactome:REACT_98771 "NaS2 co-transports sulphate and two sodium ions, Gallus gallus"
xref: Reactome:REACT_99070 "NaS1 co-transports sulphate and a sodium ion, Mus musculus"
is_a: GO:0008271 ! secondary active sulfate transmembrane transporter activity
is_a: GO:0015081 ! sodium ion transmembrane transporter activity
is_a: GO:0015296 ! anion:cation symporter activity

[Term]
id: GO:0015383
name: sulfate:bicarbonate antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + bicarbonate(in) = sulfate(in) + bicarbonate(out)." [TC:2.A.53.2.2]
synonym: "sulphate:bicarbonate antiporter activity" EXACT []
is_a: GO:0008271 ! secondary active sulfate transmembrane transporter activity
is_a: GO:0015106 ! bicarbonate transmembrane transporter activity
is_a: GO:0015301 ! anion:anion antiporter activity

[Term]
id: GO:0015385
name: sodium:proton antiporter activity
namespace: molecular_function
alt_id: GO:0015502
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)." [TC:2.A.35.1.1, TC:2.A.36.-.-]
subset: gosubset_prok
synonym: "pH-dependent sodium:hydrogen antiporter activity" NARROW []
synonym: "pH-dependent sodium:proton antiporter activity" NARROW []
synonym: "sodium/hydrogen antiporter activity" EXACT []
synonym: "sodium:hydrogen antiporter activity" EXACT []
synonym: "sodium:hydrogen exchange activity" EXACT []
synonym: "sodium:hydrogen exchanger" EXACT []
xref: Reactome:REACT_100313 "Na+/H+ exchanger transport (at cell membrane), Canis familiaris"
xref: Reactome:REACT_100581 "Na+/H+ exchanger transport (at trans-golgi membrane), Arabidopsis thaliana"
xref: Reactome:REACT_100724 "Na+/H+ exchanger transport (at cell membrane), Mycobacterium tuberculosis"
xref: Reactome:REACT_101156 "Na+/H+ exchanger transport (at late endosome membrane), Oryza sativa"
xref: Reactome:REACT_102032 "Na+/H+ exchanger transport (at late endosome membrane), Gallus gallus"
xref: Reactome:REACT_102112 "Na+/H+ exchanger transport (at late endosome membrane), Escherichia coli"
xref: Reactome:REACT_102864 "Na+/H+ exchanger transport (at trans-golgi membrane), Mus musculus"
xref: Reactome:REACT_102894 "Na+/H+ exchanger transport (at trans-golgi membrane), Oryza sativa"
xref: Reactome:REACT_105719 "Na+/H+ exchanger transport (at trans-golgi membrane), Staphylococcus aureus N315"
xref: Reactome:REACT_106807 "Na+/H+ exchanger transport (at cell membrane), Gallus gallus"
xref: Reactome:REACT_107375 "Na+/H+ exchanger transport (at cell membrane), Sus scrofa"
xref: Reactome:REACT_107865 "Na+/H+ exchanger transport (at early endosome membrane), Bos taurus"
xref: Reactome:REACT_108868 "Na+/H+ exchanger transport (at late endosome membrane), Taeniopygia guttata"
xref: Reactome:REACT_109095 "Na+/H+ exchanger transport (at early endosome membrane), Drosophila melanogaster"
xref: Reactome:REACT_109433 "Na+/H+ exchanger transport (at late endosome membrane), Staphylococcus aureus N315"
xref: Reactome:REACT_110267 "Na+/H+ exchanger transport (at early endosome membrane), Caenorhabditis elegans"
xref: Reactome:REACT_110836 "Na+/H+ exchanger transport (at cell membrane), Mus musculus"
xref: Reactome:REACT_110863 "Na+/H+ exchanger transport (at cell membrane), Xenopus tropicalis"
xref: Reactome:REACT_112054 "Na+/H+ exchanger transport (at early endosome membrane), Gallus gallus"
xref: Reactome:REACT_19218 "Na+/H+ exchanger transport (at trans-golgi membrane), Homo sapiens"
xref: Reactome:REACT_19224 "Na+/H+ exchanger transport (at cell membrane), Homo sapiens"
xref: Reactome:REACT_19253 "Na+/H+ exchanger transport (at early endosome membrane), Homo sapiens"
xref: Reactome:REACT_19303 "Na+/H+ exchanger transport (at late endosome membrane), Homo sapiens"
xref: Reactome:REACT_28080 "Na+/H+ exchanger transport (at late endosome membrane), Saccharomyces cerevisiae"
xref: Reactome:REACT_28922 "Na+/H+ exchanger transport (at late endosome membrane), Schizosaccharomyces pombe"
xref: Reactome:REACT_30436 "Na+/H+ exchanger transport (at trans-golgi membrane), Danio rerio"
xref: Reactome:REACT_30713 "Na+/H+ exchanger transport (at early endosome membrane), Danio rerio"
xref: Reactome:REACT_32407 "Na+/H+ exchanger transport (at cell membrane), Drosophila melanogaster"
xref: Reactome:REACT_32466 "Na+/H+ exchanger transport (at early endosome membrane), Taeniopygia guttata"
xref: Reactome:REACT_33295 "Na+/H+ exchanger transport (at late endosome membrane), Xenopus tropicalis"
xref: Reactome:REACT_34009 "Na+/H+ exchanger transport (at late endosome membrane), Rattus norvegicus"
xref: Reactome:REACT_34239 "Na+/H+ exchanger transport (at cell membrane), Danio rerio"
xref: Reactome:REACT_48026 "Na+/H+ exchanger transport (at trans-golgi membrane), Caenorhabditis elegans"
xref: Reactome:REACT_77239 "Na+/H+ exchanger transport (at trans-golgi membrane), Sus scrofa"
xref: Reactome:REACT_77347 "Na+/H+ exchanger transport (at trans-golgi membrane), Mycobacterium tuberculosis"
xref: Reactome:REACT_77622 "Na+/H+ exchanger transport (at early endosome membrane), Staphylococcus aureus N315"
xref: Reactome:REACT_77750 "Na+/H+ exchanger transport (at late endosome membrane), Caenorhabditis elegans"
xref: Reactome:REACT_78497 "Na+/H+ exchanger transport (at early endosome membrane), Schizosaccharomyces pombe"
xref: Reactome:REACT_78841 "Na+/H+ exchanger transport (at cell membrane), Taeniopygia guttata"
xref: Reactome:REACT_80328 "Na+/H+ exchanger transport (at early endosome membrane), Canis familiaris"
xref: Reactome:REACT_80427 "Na+/H+ exchanger transport (at trans-golgi membrane), Drosophila melanogaster"
xref: Reactome:REACT_81164 "Na+/H+ exchanger transport (at late endosome membrane), Mus musculus"
xref: Reactome:REACT_81214 "Na+/H+ exchanger transport (at early endosome membrane), Mus musculus"
xref: Reactome:REACT_81645 "Na+/H+ exchanger transport (at trans-golgi membrane), Taeniopygia guttata"
xref: Reactome:REACT_83014 "Na+/H+ exchanger transport (at late endosome membrane), Arabidopsis thaliana"
xref: Reactome:REACT_83758 "Na+/H+ exchanger transport (at late endosome membrane), Sus scrofa"
xref: Reactome:REACT_84369 "Na+/H+ exchanger transport (at late endosome membrane), Drosophila melanogaster"
xref: Reactome:REACT_85599 "Na+/H+ exchanger transport (at early endosome membrane), Sus scrofa"
xref: Reactome:REACT_86696 "Na+/H+ exchanger transport (at early endosome membrane), Mycobacterium tuberculosis"
xref: Reactome:REACT_87561 "Na+/H+ exchanger transport (at trans-golgi membrane), Gallus gallus"
xref: Reactome:REACT_89780 "Na+/H+ exchanger transport (at trans-golgi membrane), Bos taurus"
xref: Reactome:REACT_90215 "Na+/H+ exchanger transport (at trans-golgi membrane), Canis familiaris"
xref: Reactome:REACT_90329 "Na+/H+ exchanger transport (at early endosome membrane), Xenopus tropicalis"
xref: Reactome:REACT_91466 "Na+/H+ exchanger transport (at early endosome membrane), Saccharomyces cerevisiae"
xref: Reactome:REACT_92179 "Na+/H+ exchanger transport (at cell membrane), Escherichia coli"
xref: Reactome:REACT_92386 "Na+/H+ exchanger transport (at late endosome membrane), Mycobacterium tuberculosis"
xref: Reactome:REACT_92389 "Na+/H+ exchanger transport (at trans-golgi membrane), Schizosaccharomyces pombe"
xref: Reactome:REACT_92390 "Na+/H+ exchanger transport (at early endosome membrane), Oryza sativa"
xref: Reactome:REACT_92820 "Na+/H+ exchanger transport (at trans-golgi membrane), Saccharomyces cerevisiae"
xref: Reactome:REACT_93564 "Na+/H+ exchanger transport (at early endosome membrane), Escherichia coli"
xref: Reactome:REACT_94624 "Na+/H+ exchanger transport (at late endosome membrane), Canis familiaris"
xref: Reactome:REACT_94723 "Na+/H+ exchanger transport (at trans-golgi membrane), Rattus norvegicus"
xref: Reactome:REACT_95936 "Na+/H+ exchanger transport (at cell membrane), Rattus norvegicus"
xref: Reactome:REACT_96090 "Na+/H+ exchanger transport (at cell membrane), Caenorhabditis elegans"
xref: Reactome:REACT_96181 "Na+/H+ exchanger transport (at early endosome membrane), Arabidopsis thaliana"
xref: Reactome:REACT_96627 "Na+/H+ exchanger transport (at trans-golgi membrane), Escherichia coli"
xref: Reactome:REACT_96669 "Na+/H+ exchanger transport (at cell membrane), Staphylococcus aureus N315"
xref: Reactome:REACT_97077 "Na+/H+ exchanger transport (at late endosome membrane), Bos taurus"
xref: Reactome:REACT_97109 "Na+/H+ exchanger transport (at trans-golgi membrane), Dictyostelium discoideum"
xref: Reactome:REACT_98020 "Na+/H+ exchanger transport (at trans-golgi membrane), Xenopus tropicalis"
xref: Reactome:REACT_99016 "Na+/H+ exchanger transport (at cell membrane), Bos taurus"
xref: Reactome:REACT_99336 "Na+/H+ exchanger transport (at early endosome membrane), Rattus norvegicus"
xref: RHEA:29254
is_a: GO:0005451 ! monovalent cation:proton antiporter activity
is_a: GO:0015081 ! sodium ion transmembrane transporter activity

[Term]
id: GO:0015386
name: potassium:proton antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in)." [TC:2.A.37.-.-]
subset: gosubset_prok
synonym: "potassium:hydrogen antiporter activity" EXACT []
xref: RHEA:29470
is_a: GO:0005451 ! monovalent cation:proton antiporter activity
is_a: GO:0022821 ! potassium ion antiporter activity

[Term]
id: GO:0015387
name: potassium:proton symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + H+(out) = K+(in) + H+(in)." [TC:2.A.38.-.-]
synonym: "potassium:hydrogen symporter activity" EXACT []
xref: RHEA:28493
is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity
is_a: GO:0015295 ! solute:proton symporter activity
is_a: GO:0022820 ! potassium ion symporter activity

[Term]
id: GO:0015388
name: potassium uptake transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of potassium from the outside of a cell to the inside of the cell across a membrane: K+(out) + energy = K+(in)." [GOC:mtg_transport, ISBN:0815340729, TC:2.A.72.2.-]
synonym: "potassium uptake permease activity" EXACT []
is_a: GO:0015079 ! potassium ion transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity
is_a: GO:0015563 ! uptake transmembrane transporter activity

[Term]
id: GO:0015389
name: pyrimidine- and adenine-specific:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (pyrimidine nucleoside or adenine)(out) + Na+(out) = (pyrimidine nucleoside or adenine)(in) + Na+(in)." [TC:2.A.41.2.3]
is_a: GO:0005345 ! purine nucleobase transmembrane transporter activity
is_a: GO:0005350 ! pyrimidine nucleobase transmembrane transporter activity
is_a: GO:0005415 ! nucleoside:sodium symporter activity

[Term]
id: GO:0015390
name: purine-specific nucleoside:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: purine(out) + Na+(out) = nucleoside(in) + Na+(in)." [TC:2.A.41.2.1]
is_a: GO:0005415 ! nucleoside:sodium symporter activity
is_a: GO:0015211 ! purine nucleoside transmembrane transporter activity

[Term]
id: GO:0015391
name: nucleobase:cation symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleobase(out) + cation(out) = nucleobase(in) + cation(in)." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015205 ! nucleobase transmembrane transporter activity
is_a: GO:0015294 ! solute:cation symporter activity

[Term]
id: GO:0015393
name: obsolete uracil/uridine permease activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "uracil/uridine permease activity" EXACT []
is_obsolete: true
consider: GO:0015210
consider: GO:0015213
consider: GO:0022857

[Term]
id: GO:0015394
name: uridine:hydrogen ion symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: uridine(out) + H+(out) = uridine(in) + H+(in)." [GOC:mtg_transport]
synonym: "nucleoside (uridine) permease activity" RELATED []
is_a: GO:0015213 ! uridine transmembrane transporter activity
is_a: GO:0015391 ! nucleobase:cation symporter activity
is_a: GO:0015506 ! nucleoside:proton symporter activity

[Term]
id: GO:0015395
name: nucleoside transmembrane transporter activity, down a concentration gradient
namespace: molecular_function
alt_id: GO:0015396
alt_id: GO:0015397
def: "Catalysis of the transfer of a nucleoside, from one side of a membrane to the other, down the concentration gradient." [PMID:10353709, PMID:11749958, PMID:12446811]
synonym: "equilibrative nucleoside transmembrane transporter, nitrobenzyl-thioinosine-insensitive activity" NARROW []
synonym: "equilibrative nucleoside transmembrane transporter, nitrobenzyl-thioinosine-sensitive activity" NARROW []
synonym: "equilibrative nucleoside transporter activity" EXACT []
is_a: GO:0005337 ! nucleoside transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0015398
name: high-affinity secondary active ammonium transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of ammonium from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport]
synonym: "high affinity secondary active ammonium transmembrane transporter activity" EXACT []
is_a: GO:0008519 ! ammonium transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0015399
name: primary active transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute from one side of the membrane to the other, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is powered by a primary energy source, directly using ATP. Primary energy sources known to be coupled to transport are chemical, electrical and solar sources." [GOC:mtg_transport, ISBN:0815340729, TC:3.-.-.-.-]
subset: gosubset_prok
synonym: "primary active transporter" RELATED []
xref: TC:3
is_a: GO:0022804 ! active transmembrane transporter activity

[Term]
id: GO:0015400
name: low-affinity secondary active ammonium transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of ammonium from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [GOC:mtg_transport, ISBN:0815340729]
synonym: "low affinity ammonium transmembrane transporter activity" RELATED []
synonym: "low affinity secondary active ammonium transmembrane transporter activity" EXACT []
is_a: GO:0008519 ! ammonium transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0015401
name: urea:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: urea(out) + Na+(out) = urea(in) + Na+(in)." [TC:2.A.21.6.1]
synonym: "urea active transmembrane transporter activity" EXACT []
is_a: GO:0015204 ! urea transmembrane transporter activity
is_a: GO:0015370 ! solute:sodium symporter activity

[Term]
id: GO:0015403
name: thiamine uptake transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of thiamine from the outside of a cell to the inside across a membrane." [GOC:mtg_transport]
synonym: "thiamin uptake transporter activity" EXACT [GOC:curators]
is_a: GO:0015234 ! thiamine transmembrane transporter activity
is_a: GO:0015563 ! uptake transmembrane transporter activity

[Term]
id: GO:0015405
name: P-P-bond-hydrolysis-driven transmembrane transporter activity
namespace: molecular_function
def: "Primary active transport of a solute across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.A.-.-.-]
subset: gosubset_prok
synonym: "P-P-bond-hydrolysis-driven transporters" EXACT []
xref: TC:3.A
is_a: GO:0015399 ! primary active transmembrane transporter activity

[Term]
id: GO:0015406
name: obsolete ABC-type uptake permease activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because ABC transporters are a protein family rather than a functional grouping.
synonym: "ABC-type uptake permease activity" EXACT []
is_obsolete: true
consider: GO:0042626
consider: GO:0043190

[Term]
id: GO:0015407
name: monosaccharide-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + monosaccharide(out) = ADP + phosphate + monosaccharide(in). Ribose, xylose, arabinose, galactose and methylgalactoside are imported." [EC:3.6.3.17]
subset: gosubset_prok
synonym: "ATP phosphohydrolase (monosaccharide-importing)" EXACT [EC:3.6.3.17]
synonym: "monosaccharide ABC transporter" NARROW []
synonym: "monosaccharide-importing ATPase activity" NARROW []
xref: EC:3.6.3.17
xref: MetaCyc:3.6.3.17-RXN
xref: RHEA:29900
is_a: GO:0015145 ! monosaccharide transmembrane transporter activity
is_a: GO:0043211 ! carbohydrate-transporting ATPase activity

[Term]
id: GO:0015408
name: ferric-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Fe3+(out) = ADP + phosphate + Fe3+(in)." [EC:3.6.3.30]
subset: gosubset_prok
synonym: "ATP phosphohydrolase (ferric-ion-transporting)" EXACT [EC:3.6.3.30]
synonym: "Fe3+-transporting ATPase activity" EXACT [EC:3.6.3.30]
synonym: "ferric ABC transporter" NARROW []
synonym: "ferric transporting ATPase activity" EXACT []
xref: EC:3.6.3.30
xref: MetaCyc:3.6.3.30-RXN
xref: RHEA:12335
is_a: GO:0015091 ! ferric iron transmembrane transporter activity
is_a: GO:0019829 ! cation-transporting ATPase activity

[Term]
id: GO:0015410
name: manganese-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mn2+(out) = ADP + phosphate + Mn2+(in)." [EC:3.6.3.35]
subset: gosubset_prok
synonym: "ABC-type manganese permease complex" RELATED [EC:3.6.3.35]
synonym: "ATP phosphohydrolase (manganese-importing)" EXACT [EC:3.6.3.35]
synonym: "manganese ABC transporter" NARROW []
synonym: "manganese transporting ATPase activity" EXACT []
xref: EC:3.6.3.35
xref: MetaCyc:3.6.3.35-RXN
xref: RHEA:17368
is_a: GO:0005384 ! manganese ion transmembrane transporter activity
is_a: GO:0019829 ! cation-transporting ATPase activity

[Term]
id: GO:0015411
name: taurine-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + taurine(out) = ADP + phosphate + taurine(in)." [EC:3.6.3.36]
synonym: "ATP phosphohydrolase (taurine-importing)" EXACT [EC:3.6.3.36]
synonym: "taurine (2-aminoethane sulfonate) porter activity" EXACT []
synonym: "taurine ABC transporter" NARROW []
xref: EC:3.6.3.36
xref: MetaCyc:3.6.3.36-RXN
xref: RHEA:14614
is_a: GO:0005368 ! taurine transmembrane transporter activity
is_a: GO:0031263 ! amine-transporting ATPase activity

[Term]
id: GO:0015412
name: molybdate transmembrane-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + molybdate(out) = ADP + phosphate + molybdate(in)." [EC:3.6.3.29]
subset: gosubset_prok
synonym: "ATP phosphohydrolase (molybdate-importing)" EXACT [EC:3.6.3.29]
synonym: "molybdate ABC transporter" NARROW []
synonym: "molybdate porter activity" EXACT []
synonym: "molybdate transporting ATPase activity" EXACT []
synonym: "molybdate-transporting ATPase activity" EXACT [EC:3.6.3.29]
xref: EC:3.6.3.29
xref: MetaCyc:3.6.3.29-RXN
xref: RHEA:22023
is_a: GO:0015098 ! molybdate ion transmembrane transporter activity
is_a: GO:0043225 ! anion transmembrane-transporting ATPase activity

[Term]
id: GO:0015413
name: nickel-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ni2+(out) = ADP + phosphate + Ni2+(in)." [EC:3.6.3.24]
synonym: "ATP phosphohydrolase (nickel-importing)" EXACT [EC:3.6.3.24]
synonym: "nickel ABC transporter" NARROW []
synonym: "nickel porter activity" EXACT []
synonym: "nickel transporting ATPase activity" EXACT []
xref: EC:3.6.3.24
xref: MetaCyc:3.6.3.24-RXN
xref: RHEA:15560
is_a: GO:0015099 ! nickel cation transmembrane transporter activity
is_a: GO:0019829 ! cation-transporting ATPase activity
is_a: GO:0072509 ! divalent inorganic cation transmembrane transporter activity

[Term]
id: GO:0015414
name: nitrate transmembrane-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + nitrate(out) = ADP + phosphate + nitrate(in)." [EC:3.6.3.26]
synonym: "ATP phosphohydrolase (nitrate-importing)" EXACT [EC:3.6.3.26]
synonym: "nitrate ABC transporter" NARROW []
synonym: "nitrate transporting ATPase activity" EXACT []
synonym: "nitrate-transporting ATPase activity" EXACT [EC:3.6.3.26]
xref: EC:3.6.3.26
xref: MetaCyc:3.6.3.26-RXN
xref: RHEA:13184
is_a: GO:0015112 ! nitrate transmembrane transporter activity
is_a: GO:0043225 ! anion transmembrane-transporting ATPase activity

[Term]
id: GO:0015415
name: phosphate ion transmembrane-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + phosphate(out) = ADP + phosphate + phosphate(in)." [EC:3.6.3.27]
subset: gosubset_prok
synonym: "ABC phosphate transporter activity" NARROW [EC:3.6.3.27]
synonym: "ATP phosphohydrolase (phosphate-importing)" EXACT [EC:3.6.3.27]
synonym: "phosphate ABC transporter" NARROW []
synonym: "phosphate porter activity" EXACT []
synonym: "phosphate transporting ATPase activity" EXACT []
synonym: "phosphate-transporting ATPase activity" EXACT [EC:3.6.3.27]
xref: EC:3.6.3.27
xref: MetaCyc:3.6.3.27-RXN
xref: RHEA:24443
is_a: GO:0015114 ! phosphate ion transmembrane transporter activity
is_a: GO:0043225 ! anion transmembrane-transporting ATPase activity

[Term]
id: GO:0015416
name: organic phosphonate transmembrane-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + phosphonate(out) = ADP + phosphate + phosphonate(in). A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2)." [EC:3.6.3.28]
synonym: "ATP phosphohydrolase (phosphonate-transporting)" EXACT [EC:3.6.3.28]
synonym: "phosphonate ABC transporter" NARROW []
synonym: "phosphonate transporting ATPase activity" EXACT []
synonym: "phosphonate-transporting ATPase activity" EXACT [EC:3.6.3.28]
xref: EC:3.6.3.28
xref: MetaCyc:3.6.3.28-RXN
xref: RHEA:18068
is_a: GO:0015604 ! organic phosphonate transmembrane transporter activity
is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity
is_a: GO:0043225 ! anion transmembrane-transporting ATPase activity

[Term]
id: GO:0015417
name: polyamine-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O + polyamine(out) = ADP + phosphate + polyamine(in)." [EC:3.6.3.31]
subset: gosubset_prok
synonym: "ATP phosphohydrolase (polyamine-importing) activity" EXACT [EC:3.6.3.31]
synonym: "polyamine ABC transporter" NARROW []
synonym: "polyamine porter activity" EXACT []
synonym: "polyamine-importing ATPase activity" NARROW []
xref: EC:3.6.3.31
xref: MetaCyc:3.6.3.31-RXN
is_a: GO:0015203 ! polyamine transmembrane transporter activity
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances

[Term]
id: GO:0015418
name: quaternary-ammonium-compound-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O + quaternary amine(out) = ADP + phosphate + quaternary amine(in)." [EC:3.6.3.32]
subset: gosubset_prok
synonym: "ATP phosphohydrolase (quaternary-amine-importing) activity" EXACT [EC:3.6.3.32]
synonym: "glycine betaine/proline porter activity" RELATED []
synonym: "quaternary amine uptake transporter activity" EXACT []
synonym: "quaternary-amine-transporting ATPase activity" EXACT []
synonym: "quaternary-ammonium-compound ABC transporter" NARROW []
xref: EC:3.6.3.32
xref: MetaCyc:3.6.3.32-RXN
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances

[Term]
id: GO:0015419
name: sulfate transmembrane-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + sulfate(out) = ADP + phosphate + sulfate(in)." [EC:3.6.3.25]
subset: gosubset_prok
synonym: "ATP phosphohydrolase (sulfate-importing) activity" EXACT [EC:3.6.3.25]
synonym: "sulfate ABC transporter" NARROW []
synonym: "sulfate transporting ATPase activity" EXACT []
synonym: "sulfate-transporting ATPase activity" EXACT [EC:3.6.3.25]
synonym: "sulfate/thiosulfate porter activity" EXACT []
synonym: "sulphate transporting ATPase activity" EXACT []
synonym: "sulphate-transporting ATPase activity" EXACT []
xref: EC:3.6.3.25
xref: MetaCyc:3.6.3.25-RXN
xref: Reactome:REACT_27230 "sulfate uptake in the cytosol, Mycobacterium tuberculosis"
xref: RHEA:10195
is_a: GO:0015116 ! sulfate transmembrane transporter activity
is_a: GO:0043225 ! anion transmembrane-transporting ATPase activity

[Term]
id: GO:0015420
name: cobalamin-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O + cob(III)alamin(out) = ADP + phosphate + cob(III)alamin(in). Cobalamin is also known as vitamin B12." [EC:3.6.3.33]
subset: gosubset_prok
synonym: "ATP phosphohydrolase (vitamin B12-importing)" EXACT [EC:3.6.3.33]
synonym: "cobalamin ABC transporter" NARROW []
synonym: "cobalamin porter activity" EXACT []
synonym: "vitamin B12 porter activity" EXACT []
synonym: "vitamin B12-transporting ATPase activity" EXACT []
xref: EC:3.6.3.33
xref: MetaCyc:3.6.3.33-RXN
xref: RHEA:17876
is_a: GO:0015235 ! cobalamin transporter activity
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances
is_a: GO:0090482 ! vitamin transmembrane transporter activity

[Term]
id: GO:0015421
name: oligopeptide-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O + oligopeptide(out) = ADP + phosphate + oligopeptide(in)." [EC:3.6.3.23]
subset: gosubset_prok
synonym: "ATP phosphohydrolase (oligopeptide-importing)" EXACT [EC:3.6.3.23]
synonym: "oligopeptide ABC transporter" NARROW []
synonym: "oligopeptide permease activity" RELATED [EC:3.6.3.23]
xref: EC:3.6.3.23
xref: MetaCyc:3.6.3.23-RXN
is_a: GO:0015440 ! peptide-transporting ATPase activity
is_a: GO:0035673 ! oligopeptide transmembrane transporter activity

[Term]
id: GO:0015422
name: oligosaccharide-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + oligosaccharide(out) = ADP + phosphate + oligosaccharide(in)." [EC:3.6.3.18]
subset: gosubset_prok
synonym: "ATP phosphohydrolase (disaccharide-importing)" EXACT [EC:3.6.3.18]
synonym: "oligosaccharide ABC transporter" NARROW []
xref: EC:3.6.3.18
xref: MetaCyc:3.6.3.18-RXN
xref: RHEA:20364
is_a: GO:0015157 ! oligosaccharide transmembrane transporter activity
is_a: GO:0043211 ! carbohydrate-transporting ATPase activity

[Term]
id: GO:0015423
name: maltose-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + maltose(out) = ADP + phosphate + maltose(in)." [EC:3.6.3.19]
subset: gosubset_prok
synonym: "ATP phosphohydrolase (maltose-importing)" EXACT [EC:3.6.3.19]
synonym: "maltose ABC transporter" NARROW []
xref: EC:3.6.3.19
xref: MetaCyc:3.6.3.19-RXN
xref: RHEA:22135
is_a: GO:0005363 ! maltose transmembrane transporter activity
is_a: GO:0015422 ! oligosaccharide-transporting ATPase activity

[Term]
id: GO:0015424
name: amino acid-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + amino acid(out/in) = ADP + phosphate + amino acid(in/out)." [GOC:ai, GOC:mah]
subset: gosubset_prok
synonym: "amino acid ABC transporter" NARROW []
is_a: GO:0015171 ! amino acid transmembrane transporter activity
is_a: GO:0031263 ! amine-transporting ATPase activity

[Term]
id: GO:0015425
name: nonpolar-amino acid-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + nonpolar amino acid(out) = ADP + phosphate + nonpolar amino acid(in)." [EC:3.6.3.22]
synonym: "ATP phosphohydrolase (nonpolar-amino-acid-transporting) activity" EXACT [EC:3.6.3.22]
synonym: "leucine/isoleucine/valine porter activity" RELATED []
synonym: "nonpolar amino acid-transporting ATPase activity" EXACT []
synonym: "nonpolar-amino acid ABC transporter" NARROW []
synonym: "nonpolar-amino-acid-transporting ATPase activity" EXACT []
xref: EC:3.6.3.22
xref: MetaCyc:3.6.3.22-RXN
is_a: GO:0015424 ! amino acid-transporting ATPase activity

[Term]
id: GO:0015426
name: polar-amino acid-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in)." [EC:3.6.3.21]
subset: gosubset_prok
synonym: "ATP phosphohydrolase (polar-amino-acid-importing) activity" EXACT [EC:3.6.3.21]
synonym: "cystine/diaminopimelate porter activity" RELATED []
synonym: "glutamate/aspartate porter activity" RELATED []
synonym: "histidine permease activity" NARROW [EC:3.6.3.21]
synonym: "histidine/arginine/lysine/ornithine porter activity" RELATED []
synonym: "polar amino acid uptake transporter activity" EXACT []
synonym: "polar amino acid-importing ATPase activity" EXACT []
synonym: "polar-amino acid ABC transporter" NARROW []
synonym: "polar-amino acid-importing ATPase activity" EXACT []
synonym: "polar-amino-acid-transporting ATPase activity" EXACT [EC:3.6.3.21]
xref: EC:3.6.3.21
xref: MetaCyc:3.6.3.21-RXN
is_a: GO:0015424 ! amino acid-transporting ATPase activity

[Term]
id: GO:0015427
name: obsolete ABC-type efflux porter activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because ABC transporters are a protein family rather than a functional grouping.
synonym: "ABC-type efflux porter activity" EXACT []
is_obsolete: true
consider: GO:0042626
consider: GO:0043190

[Term]
id: GO:0015428
name: obsolete type I protein secretor activity
namespace: molecular_function
def: "OBSOLETE." [GOC:mtg_transport]
comment: This term was made obsolete because it does not accurately reflect the function of the proteins involved.
synonym: "type I protein secretor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0015429
name: obsolete peroxisomal fatty acyl transporter
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it describes a gene product and it contains both component and function information.
synonym: "peroxisomal fatty acyl transporter" EXACT []
is_obsolete: true
consider: GO:0005777
consider: GO:0015246

[Term]
id: GO:0015430
name: glycerol-3-phosphate-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + glycerol-3-phosphate(out) = ADP + phosphate + glycerol-3-phosphate(in)." [EC:3.6.3.20]
subset: gosubset_prok
synonym: "ATP phosphohydrolase (glycerol-3-phosphate-importing)" EXACT [EC:3.6.3.20]
synonym: "glycerol-3-phosphate ABC transporter" NARROW []
xref: EC:3.6.3.20
xref: MetaCyc:3.6.3.20-RXN
xref: RHEA:21669
is_a: GO:0015169 ! glycerol-3-phosphate transmembrane transporter activity
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances

[Term]
id: GO:0015431
name: glutathione S-conjugate-exporting ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O + glutathione S-conjugate(in) -> ADP + phosphate + glutathione S-conjugate(out)." [GOC:jl, PMID:1455517]
synonym: "ATP-dependent glutathione S-conjugate export pump" EXACT []
synonym: "conjugate transporter activity" BROAD []
synonym: "GS-X pump" EXACT []
synonym: "MRP1/GS-X pump" EXACT []
is_a: GO:0071997 ! glutathione S-conjugate-transporting ATPase activity

[Term]
id: GO:0015432
name: bile acid-exporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(in) + ATP + H2O -> bile acid(out) + ADP + phosphate." [TC:3.A.1.207.2]
synonym: "bile acid porter activity" NARROW []
xref: Reactome:REACT_10078 "Transport (efflux) of bile salts by ABCC3 (MRP3), Homo sapiens"
xref: Reactome:REACT_10101 "Transport (efflux) of bile salts by ABCB11 (bile salt export pump), Homo sapiens"
xref: Reactome:REACT_103931 "Transport (efflux) of bile salts by ABCB11 (bile salt export pump), Mus musculus"
xref: Reactome:REACT_109115 "Transport (efflux) of bile salts by ABCB11 (bile salt export pump), Drosophila melanogaster"
xref: Reactome:REACT_112096 "Transport (efflux) of bile salts by ABCB11 (bile salt export pump), Plasmodium falciparum"
xref: Reactome:REACT_112416 "Transport (efflux) of bile salts by ABCB11 (bile salt export pump), Dictyostelium discoideum"
xref: Reactome:REACT_113803 "Transport (efflux) of bile salts by ABCB11 (bile salt export pump), Schizosaccharomyces pombe"
xref: Reactome:REACT_113836 "Transport (efflux) of bile salts by ABCB11 (bile salt export pump), Arabidopsis thaliana"
xref: Reactome:REACT_114961 "Transport (efflux) of bile salts by ABCB11 (bile salt export pump), Oryza sativa"
xref: Reactome:REACT_118113 "Transport (efflux) of bile salts by ABCC3 (MRP3), Bos taurus"
xref: Reactome:REACT_118145 "Transport (efflux) of bile salts by ABCC3 (MRP3), Danio rerio"
xref: Reactome:REACT_118146 "Transport (efflux) of bile salts by ABCC3 (MRP3), Xenopus tropicalis"
xref: Reactome:REACT_118208 "Transport (efflux) of bile salts by ABCC3 (MRP3), Mus musculus"
xref: Reactome:REACT_118235 "Transport (efflux) of bile salts by ABCC3 (MRP3), Canis familiaris"
xref: Reactome:REACT_118240 "Transport (efflux) of bile salts by ABCC3 (MRP3), Taeniopygia guttata"
xref: Reactome:REACT_118275 "Transport (efflux) of bile salts by ABCC3 (MRP3), Rattus norvegicus"
xref: Reactome:REACT_118558 "Transport (efflux) of bile salts by ABCC3 (MRP3), Sus scrofa"
xref: Reactome:REACT_28407 "Transport (efflux) of bile salts by ABCB11 (bile salt export pump), Xenopus tropicalis"
xref: Reactome:REACT_32025 "Transport (efflux) of bile salts by ABCB11 (bile salt export pump), Sus scrofa"
xref: Reactome:REACT_77555 "Transport (efflux) of bile salts by ABCB11 (bile salt export pump), Danio rerio"
xref: Reactome:REACT_77986 "Transport (efflux) of bile salts by ABCB11 (bile salt export pump), Canis familiaris"
xref: Reactome:REACT_82564 "Transport (efflux) of bile salts by ABCB11 (bile salt export pump), Taeniopygia guttata"
xref: Reactome:REACT_88489 "Transport (efflux) of bile salts by ABCB11 (bile salt export pump), Bos taurus"
xref: Reactome:REACT_94132 "Transport (efflux) of bile salts by ABCB11 (bile salt export pump), Gallus gallus"
is_a: GO:0015125 ! bile acid transmembrane transporter activity
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances

[Term]
id: GO:0015433
name: peptide antigen-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: peptide antigen(in) + ATP = peptide antigen(out) + ADP + phosphate." [TC:3.A.1.209.1]
synonym: "major histocompatibility peptide transporter activity" EXACT []
synonym: "peptide antigen ABC transporter" NARROW []
synonym: "peptide antigen transporter activity" BROAD []
xref: Reactome:REACT_111185 "Translocation of antigenic peptides back to phagosomes via TAP, Homo sapiens"
xref: Reactome:REACT_75812 "Transport of Antigen peptide in to ER, Homo sapiens"
is_a: GO:0015440 ! peptide-transporting ATPase activity

[Term]
id: GO:0015434
name: cadmium-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cd (cytosol) = ADP + phosphate + Cd (vacuole)." [EC:3.6.3.46]
subset: gosubset_prok
synonym: "ATP phosphohydrolase (heavy-metal-exporting)" EXACT [EC:3.6.3.46]
synonym: "cadmium ABC transporter" NARROW []
synonym: "yeast cadmium factor" RELATED [EC:3.6.3.46]
xref: EC:3.6.3.46
xref: MetaCyc:3.6.3.46-RXN
is_a: GO:0015086 ! cadmium ion transmembrane transporter activity

[Term]
id: GO:0015435
name: obsolete ABC-type efflux permease activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because ABC transporters are a protein family rather than a functional grouping.
synonym: "ABC-type efflux permease activity" EXACT []
is_obsolete: true
consider: GO:0042626
consider: GO:0043190

[Term]
id: GO:0015436
name: capsular-polysaccharide-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + capsular polysaccharide(in) = ADP + phosphate + capsular polysaccharide(out)." [EC:3.6.3.38]
subset: gosubset_prok
synonym: "ATP phosphohydrolase (capsular-polysaccharide-exporting)" EXACT [EC:3.6.3.38]
synonym: "capsular-polysaccharide ABC transporter" NARROW []
xref: EC:3.6.3.38
xref: MetaCyc:3.6.3.38-RXN
is_a: GO:0015161 ! capsular polysaccharide transmembrane transporter activity
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances

[Term]
id: GO:0015437
name: lipopolysaccharide-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + lipopolysaccharide(in) = ADP + phosphate + lipopolysaccharide(out)." [EC:3.6.3.39]
subset: gosubset_prok
synonym: "ATP phosphohydrolase (lipopolysaccharide-exporting)" EXACT [EC:3.6.3.39]
synonym: "lipopolysaccharide ABC transporter" NARROW []
synonym: "LPS-transporting ATPase activity" EXACT []
xref: EC:3.6.3.39
xref: MetaCyc:3.6.3.39-RXN
is_a: GO:0015221 ! lipopolysaccharide transmembrane transporter activity
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances

[Term]
id: GO:0015438
name: teichoic-acid-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + teichoic acid(in) = ADP + phosphate + teichoic acid(out)." [EC:3.6.3.40]
subset: gosubset_prok
synonym: "ATP phosphohydrolase (teichoic-acid-exporting)" EXACT [EC:3.6.3.40]
synonym: "teichoic-acid ABC transporter" NARROW []
xref: EC:3.6.3.40
xref: MetaCyc:3.6.3.40-RXN
is_a: GO:0015162 ! teichoic acid transmembrane transporter activity
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances

[Term]
id: GO:0015439
name: heme-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O + heme(in) = ADP + phosphate + heme(out)." [EC:3.6.3.41]
subset: gosubset_prok
synonym: "ATP phosphohydrolase (heme-exporting)" EXACT [EC:3.6.3.41]
synonym: "haem-transporting ATPase activity" EXACT []
synonym: "heme ABC transporter" NARROW []
xref: EC:3.6.3.41
xref: MetaCyc:3.6.3.41-RXN
is_a: GO:0015232 ! heme transporter activity
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances

[Term]
id: GO:0015440
name: peptide-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O + peptide(in) = ADP + phosphate + peptide(out). Peptides exported include alpha-hemolysin, cyclolysin, colicin V and siderophores from Gram-negative bacteria, and bacteriocin, subtilin, competence factor and pediocin from Gram-positive bacteria." [EC:3.6.3.43]
subset: gosubset_prok
synonym: "ATP phosphohydrolase (peptide-exporting)" EXACT [EC:3.6.3.43]
synonym: "peptide ABC transporter" NARROW []
xref: EC:3.6.3.43
xref: MetaCyc:3.6.3.43-RXN
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances
is_a: GO:1904680 ! peptide transmembrane transporter activity

[Term]
id: GO:0015441
name: beta-glucan-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + beta-glucan(in) = ADP + phosphate + beta-glucan(out)." [EC:3.6.3.42]
synonym: "ATP phosphohydrolase (beta-glucan-exporting)" EXACT [EC:3.6.3.42]
synonym: "beta-glucan ABC transporter" NARROW []
xref: EC:3.6.3.42
xref: MetaCyc:3.6.3.42-RXN
is_a: GO:0015160 ! beta-glucan transmembrane transporter activity
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances

[Term]
id: GO:0015442
name: obsolete hydrogen-/sodium-translocating ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + (Na+ or H+)(in) = ADP + phosphate + (Na+ or H+)(out)." [TC:3.A.2.-.-]
comment: This term was made obsolete because it is a redundant grouping term based on a TC-DB classification.
synonym: "hydrogen-/sodium-translocating ATPase activity" EXACT []
synonym: "proton-/sodium-translocating ATPase activity" EXACT []
is_obsolete: true
consider: GO:0008553
consider: GO:0008554

[Term]
id: GO:0015443
name: obsolete sodium-transporting two-sector ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out)." [EC:3.6.3.15]
comment: This term was made obsolete because it refers to a bifunctional gene product.
synonym: "sodium-transporting two-sector ATPase activity" EXACT []
is_obsolete: true
consider: GO:0046932
consider: GO:0046962

[Term]
id: GO:0015444
name: magnesium-importing ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mg2+(out) -> ADP + phosphate + Mg2+(in)." [EC:3.6.3.2]
subset: gosubset_prok
synonym: "ATP phosphohydrolase (Mg2+-importing)" EXACT [EC:3.6.3.2]
synonym: "magnesium importing ATPase activity" EXACT []
synonym: "magnesium-translocating P-type ATPase activity" RELATED [EC:3.6.3.2]
synonym: "Mg(2+)-importing ATPase activity" EXACT [EC:3.6.3.2]
synonym: "Mg2+-importing ATPase activity" EXACT [EC:3.6.3.2]
xref: EC:3.6.3.2
xref: MetaCyc:3.6.3.2-RXN
xref: RHEA:10263
is_a: GO:0015095 ! magnesium ion transmembrane transporter activity
is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
is_a: GO:0019829 ! cation-transporting ATPase activity

[Term]
id: GO:0015445
name: silver-exporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ag+(in) -> ADP + phosphate + Ag+(out)." [EC:3.6.3.53]
subset: gosubset_prok
synonym: "Ag+-exporting ATPase activity" EXACT [EC:3.6.3.53]
synonym: "ATP phosphohydrolase (Ag+-exporting)" EXACT [EC:3.6.3.53]
synonym: "silver exporting ATPase activity" EXACT []
xref: EC:3.6.3.53
xref: MetaCyc:3.6.3.53-RXN
xref: RHEA:14736
is_a: GO:0015080 ! silver ion transmembrane transporter activity
is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
is_a: GO:0019829 ! cation-transporting ATPase activity

[Term]
id: GO:0015446
name: arsenite-transmembrane transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + arsenite(in) = ADP + phosphate + arsenite(out)." [EC:3.6.3.16]
subset: gosubset_prok
synonym: "arsenical pump-driving ATPase activity" EXACT [EC:3.6.3.16]
synonym: "arsenical resistance ATPase activity" EXACT [EC:3.6.3.16]
synonym: "arsenical resistance efflux pump" EXACT []
synonym: "arsenite ABC transporter" NARROW []
synonym: "arsenite transporting ATPase activity" EXACT []
synonym: "arsenite-translocating ATPase activity" EXACT [EC:3.6.3.16]
synonym: "arsenite-transporting ATPase activity" EXACT [EC:3.6.3.16, GOC:vw]
synonym: "ATP phosphohydrolase (arsenite-exporting) activity" EXACT [EC:3.6.3.16]
xref: EC:3.6.3.16
xref: MetaCyc:3.6.3.16-RXN
xref: RHEA:11351
is_a: GO:0008490 ! arsenite secondary active transmembrane transporter activity
is_a: GO:0019829 ! cation-transporting ATPase activity
is_a: GO:0043225 ! anion transmembrane-transporting ATPase activity

[Term]
id: GO:0015447
name: obsolete type II protein secretor activity
namespace: molecular_function
def: "OBSOLETE." [GOC:mtg_transport]
comment: This term was made obsolete because it does not accurately reflect the function of the proteins involved.
synonym: "type II protein secretor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0015448
name: obsolete type III protein (virulence-related) secretor activity
namespace: molecular_function
def: "OBSOLETE." [GOC:mtg_transport]
comment: This term was made obsolete because it does not accurately reflect the function of the proteins involved.
synonym: "type III protein (virulence-related) secretor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0015449
name: obsolete type IV protein (DNA-protein) secretor activity
namespace: molecular_function
def: "OBSOLETE." [GOC:mtg_transport]
comment: This term was made obsolete because it does not accurately reflect the function of the proteins involved.
synonym: "type IV protein (DNA-protein) secretor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0015450
name: P-P-bond-hydrolysis-driven protein transmembrane transporter activity
namespace: molecular_function
def: "Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated." [GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "protein translocase activity" EXACT []
is_a: GO:0008320 ! protein transmembrane transporter activity
is_a: GO:0015405 ! P-P-bond-hydrolysis-driven transmembrane transporter activity

[Term]
id: GO:0015451
name: decarboxylation-driven active transmembrane transporter activity
namespace: molecular_function
def: "Primary active transport of a solute across a membrane driven by decarboxylation of a cytoplasmic substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.B.-.-.-]
subset: gosubset_prok
synonym: "Decarboxylation-driven transporters" RELATED []
xref: TC:3.B
is_a: GO:0015399 ! primary active transmembrane transporter activity

[Term]
id: GO:0015452
name: methyl transfer-driven active transmembrane transporter activity
namespace: molecular_function
def: "Primary active transport of a solute across a membrane driven by a methyl transfer reaction. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.C.-.-.-]
synonym: "Methyltransfer-driven transporters" EXACT []
xref: TC:3.C
is_a: GO:0015399 ! primary active transmembrane transporter activity

[Term]
id: GO:0015453
name: oxidoreduction-driven active transmembrane transporter activity
namespace: molecular_function
def: "Primary active transport of a solute across a membrane, driven by exothermic flow of electrons from a reduced substrate to an oxidized substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.D.-.-.-]
subset: gosubset_prok
synonym: "Oxidoreduction-driven transporters" EXACT []
xref: TC:3.D
is_a: GO:0015399 ! primary active transmembrane transporter activity

[Term]
id: GO:0015454
name: light-driven active transmembrane transporter activity
namespace: molecular_function
def: "Primary active transport of a solute across a membrane, driven by light. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.E.-.-.-]
synonym: "Light absorption-driven transporters" EXACT []
synonym: "light-driven pumps" EXACT []
xref: TC:3.E
is_a: GO:0015399 ! primary active transmembrane transporter activity

[Term]
id: GO:0015459
name: potassium channel regulator activity
namespace: molecular_function
def: "Modulates the activity of a potassium channel." [GOC:mah]
is_a: GO:0016247 ! channel regulator activity
relationship: regulates GO:0005267 ! potassium channel activity

[Term]
id: GO:0015461
name: obsolete endosomal oligosaccharide transporter
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it contains both component and function information.
synonym: "endosomal oligosaccharide transporter" EXACT []
is_obsolete: true
consider: GO:0005768
consider: GO:0015157

[Term]
id: GO:0015462
name: protein-transmembrane transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + protein(out) = ADP + phosphate + protein(in)." [EC:3.6.1.3, GOC:jl]
synonym: "pilin/fimbrilin exporter activity" NARROW []
synonym: "protein ABC transporter" NARROW []
synonym: "protein-transporting ATPase activity" EXACT []
is_a: GO:0015450 ! P-P-bond-hydrolysis-driven protein transmembrane transporter activity
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances

[Term]
id: GO:0015464
name: acetylcholine receptor activity
namespace: molecular_function
def: "Combining with acetylcholine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
comment: For nicotinic acetylcholine receptors that act as ion channels, instead use 'acetylcholine-gated cation channel activity ; GO:0005892'.
is_a: GO:0004888 ! transmembrane signaling receptor activity
is_a: GO:0030594 ! neurotransmitter receptor activity
relationship: has_part GO:0042166 ! acetylcholine binding

[Term]
id: GO:0015465
name: obsolete lysin activity
namespace: molecular_function
def: "OBSOLETE. An agent that can lyse cells." [ISBN:0198547684]
comment: This term was made obsolete because it represents a class of gene products.
synonym: "lysin activity" EXACT []
is_obsolete: true
consider: GO:0019835

[Term]
id: GO:0015466
name: obsolete autolysin activity
namespace: molecular_function
def: "OBSOLETE. An agent that can lyse the cell in which it is synthesized." [GOC:ma]
comment: This term was made obsolete because it represents a class of gene products.
synonym: "autolysin activity" EXACT []
is_obsolete: true
consider: GO:0019835

[Term]
id: GO:0015467
name: G-protein activated inward rectifier potassium channel activity
namespace: molecular_function
alt_id: GO:0015273
def: "Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by a G protein. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force." [GOC:cb, GOC:mah]
synonym: "G protein activated inward rectifier potassium channel activity" EXACT []
synonym: "G protein enhanced inward rectifier potassium channel activity" EXACT []
synonym: "G-protein enhanced inward rectifier potassium channel activity" EXACT []
synonym: "G-protein-activated inward rectifier potassium channel activity" EXACT []
synonym: "G-protein-enhanced inward rectifier potassium channel activity" EXACT []
xref: Reactome:REACT_108852 "Activation of GIRK/Kir3 Channels, Rattus norvegicus"
xref: Reactome:REACT_110369 "Activation of GIRK/Kir3 Channels, Taeniopygia guttata"
xref: Reactome:REACT_114055 "Activation of GIRK/Kir3 Channels, Xenopus tropicalis"
xref: Reactome:REACT_25066 "Activation of GIRK/Kir3 Channels, Homo sapiens"
xref: Reactome:REACT_28327 "Activation of GIRK/Kir3 Channels, Canis familiaris"
xref: Reactome:REACT_32795 "Activation of GIRK/Kir3 Channels, Sus scrofa"
xref: Reactome:REACT_85280 "Activation of GIRK/Kir3 Channels, Bos taurus"
xref: Reactome:REACT_94395 "Activation of GIRK/Kir3 Channels, Mus musculus"
xref: Reactome:REACT_95129 "Activation of GIRK/Kir3 Channels, Danio rerio"
is_a: GO:0005242 ! inward rectifier potassium channel activity

[Term]
id: GO:0015468
name: obsolete colicin
namespace: molecular_function
def: "OBSOLETE. Plasmid-encoded bacteriocins which are produced by enteric bacteria. Exert a lethal effect on other bacteria including E. coli strains that lack the Col plasmid. Bind to a cell surface receptor and are transported into the periplasm via an energy-dependent process involving a TonB- or TolA-dependent hetero-oligomeric protein complex. Some colicins kill their target cell by inserting into the cytoplasmic membrane where they form voltage-sensitive (trans-negative) channels that depolarize and deenergize the cell, and thereby kill it." [TC:1.C.1.-.-]
comment: This term was made obsolete because it represents a class of gene products.
synonym: "colicin" EXACT []
is_obsolete: true
consider: GO:0005102
consider: GO:0005198
consider: GO:0009405
consider: GO:0019835
consider: GO:0046930
consider: GO:0046931
consider: GO:0050827

[Term]
id: GO:0015469
name: obsolete channel-forming toxin activity
namespace: molecular_function
def: "OBSOLETE. A toxin that exerts its effects by forming a channel in a membrane that allows the unregulated passage of substances into and out of the cell." [GOC:ai]
comment: This term was made obsolete because it represents a class of gene products.
synonym: "channel-forming toxin activity" EXACT []
is_obsolete: true
consider: GO:0009405
consider: GO:0015267
consider: GO:0035915
consider: GO:0046930
consider: GO:0050827

[Term]
id: GO:0015470
name: obsolete bacteriocin activity
namespace: molecular_function
def: "OBSOLETE. Polypeptide antibiotic secreted by bacteria and able to kill bacteria of susceptible strains after absorption by specific cell surface receptor." [ISBN:0198547684]
comment: This term was made obsolete because it represents a gene product.
synonym: "bacteriocin activity" EXACT []
is_obsolete: true
consider: GO:0005102
consider: GO:0019835

[Term]
id: GO:0015471
name: nucleoside-specific channel forming porin activity
namespace: molecular_function
def: "Enables the energy independent passage of nucleoside, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport]
is_a: GO:0005337 ! nucleoside transmembrane transporter activity
is_a: GO:0015288 ! porin activity

[Term]
id: GO:0015472
name: obsolete fimbrium-specific chaperone activity
namespace: molecular_function
def: "OBSOLETE. Assists in the correct assembly of fimbria, extracellular organelles that are used to attach a bacterial cell to a surface, but is not a component of the fimbrium when performing its normal biological function." [GOC:jl, GOC:rb, PMID:7906046]
comment: This term was made obsolete because it refers to a class of proteins and a biological process rather than a molecular function.
synonym: "fimbrium-specific chaperone activity" EXACT []
is_obsolete: true
consider: GO:0009297
consider: GO:0030674
consider: GO:0044183
consider: GO:0051082

[Term]
id: GO:0015473
name: fimbrial usher porin activity
namespace: molecular_function
def: "A porin that acts in the assembly of fimbria together with fimbrial chaperone." [TC:1.B.11.-.-]
is_a: GO:0015288 ! porin activity

[Term]
id: GO:0015474
name: autotransporter activity
namespace: molecular_function
def: "Transports a passenger protein from the periplasm to the external milieu; the passenger protein and the porin are the N- and C-terminal regions of the same protein, respectively." [GOC:mtg_transport, ISBN:0815340729, TC:1.B.12.-.-]
subset: gosubset_prok
is_a: GO:0015266 ! protein channel activity
is_a: GO:0015288 ! porin activity

[Term]
id: GO:0015475
name: adhesin autotransporter activity
namespace: molecular_function
def: "Catalysis of the transfer of adhesin from the periplasm to the external milieu; the adhesin and the porin are the N- and C-terminal regions of the same protein, respectively." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015474 ! autotransporter activity

[Term]
id: GO:0015476
name: hemaglutinin autotransporter activity
namespace: molecular_function
def: "Catalysis of the transfer of hemaglutinin from the periplasm to the external milieu; the hemaglutinin and the porin are the N- and C-terminal regions of the same protein, respectively." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015474 ! autotransporter activity

[Term]
id: GO:0015477
name: obsolete receptor porin activity
namespace: molecular_function
def: "OBSOLETE. A porin of the bacterial outer membrane that forms transmembrane pores and transports relatively large molecules from the external milieu to the periplasm in an energized process. Energizing of transport across the outer membrane requires a heterotrimeric complex of proteins, the TonB-ExbB-ExbD complex, or in some cases, the TolA-TolQ-TolR complex. Energizing requires proton motive force across the cytoplasmic membrane." [GOC:mtg_transport, ISBN:0815340729, TC:1.B.13.-.-]
comment: This term was made obsolete because it combines two functions that are not linked.
synonym: "receptor porin activity" EXACT []
is_obsolete: true

[Term]
id: GO:0015478
name: oligosaccharide transporting porin activity
namespace: molecular_function
def: "Catalysis of the transfer of oligosaccharide, sized less than 1000 Da, from one side of the membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport]
synonym: "raffinose porin" NARROW []
is_a: GO:0015157 ! oligosaccharide transmembrane transporter activity
is_a: GO:0015288 ! porin activity

[Term]
id: GO:0015479
name: obsolete outer membrane exporter porin
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it contains both component and function information.
synonym: "outer membrane exporter porin" EXACT []
is_obsolete: true
consider: GO:0009279
consider: GO:0015288

[Term]
id: GO:0015480
name: obsolete secretin (sensu Bacteria)
namespace: molecular_function
def: "OBSOLETE. Secretins are Gram-negative bacterial outer membrane proteins that form multimeric pores through which macromolecules, usually proteins, can pass. Form homomultimeric ring structures, 10-20 subunits per complex, with large central pores (inner diameters of 5-10 nm)." [TC:1.B.22.-.-]
comment: This term was made obsolete because it represents a class of gene products.
synonym: "secretin (sensu Bacteria)" EXACT []
is_obsolete: true
consider: GO:0008565
consider: GO:0045203

[Term]
id: GO:0015481
name: maltose transporting porin activity
namespace: molecular_function
def: "Catalysis of the transfer of maltose from one side of the membrane to the other. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the enzymatic breakdown of glycogen and starch. This transporter is a porin so enables the energy independent passage of substances, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport]
subset: gosubset_prok
synonym: "maltoporin" EXACT []
xref: Wikipedia:Maltoporin
is_a: GO:0005363 ! maltose transmembrane transporter activity
is_a: GO:0015288 ! porin activity

[Term]
id: GO:0015482
name: obsolete voltage-gated anion channel porin activity
namespace: molecular_function
def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729]
comment: This term was made obsolete because it wrongly combines voltage-gated anion channel activity and porin activity.
synonym: "voltage-dependent anion channel porin activity" EXACT []
synonym: "voltage-gated anion channel porin activity" EXACT []
is_obsolete: true

[Term]
id: GO:0015483
name: long-chain fatty acid transporting porin activity
namespace: molecular_function
def: "Enables the transfer of long-chain fatty acids from one side of the membrane to the other. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. This transporter is a porin and so enables the energy independent passage of substances, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [CHEBI:15904, GOC:mtg_transport]
is_a: GO:0005253 ! anion channel activity
is_a: GO:0005324 ! long-chain fatty acid transporter activity
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:0015288 ! porin activity

[Term]
id: GO:0015484
name: obsolete hemolysin activity
namespace: molecular_function
def: "OBSOLETE. Any substance that causes the lysis of red blood cells." [ISBN:0198506732]
comment: This term was made obsolete because it represents a gene product.
synonym: "hemolysin activity" EXACT []
is_obsolete: true
consider: GO:0019836

[Term]
id: GO:0015485
name: cholesterol binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:jl, ISBN:0198506732]
is_a: GO:0032934 ! sterol binding

[Term]
id: GO:0015486
name: glycoside-pentoside-hexuronide:cation symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (glycoside, pentoside or hexuronide)(out) + monovalent cation(out) = (glycoside, pentoside or hexuronide)(in) + monovalent cation(in). The cation is Na+, Li+ or H+." [TC:2.A.2.-.-]
is_a: GO:0005402 ! cation:sugar symporter activity

[Term]
id: GO:0015487
name: melibiose:monovalent cation symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: melibiose(out) + monovalent cation(out) = melibiose(in) + monovalent cation(in)." [TC:2.A.2.1.1]
subset: gosubset_prok
synonym: "melibiose permease activity" RELATED []
is_a: GO:0015156 ! melibiose transmembrane transporter activity
is_a: GO:0015486 ! glycoside-pentoside-hexuronide:cation symporter activity

[Term]
id: GO:0015488
name: glucuronide:monovalent cation symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucuronide(out) + monovalent cation(out) = glucuronide(in) + monovalent cation(in)." [TC:2.A.2.3.1]
synonym: "glucuronoside permease activity" RELATED []
is_a: GO:0015164 ! glucuronoside transmembrane transporter activity
is_a: GO:0015486 ! glycoside-pentoside-hexuronide:cation symporter activity

[Term]
id: GO:0015489
name: putrescine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of putrescine from one side of the membrane to the other. Putrescine is 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008519 ! ammonium transmembrane transporter activity
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:0015203 ! polyamine transmembrane transporter activity
relationship: part_of GO:0015847 ! putrescine transport

[Term]
id: GO:0015490
name: cadaverine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of cadaverine, 1,5-pentanediamine, from one side of the membrane to the other." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008519 ! ammonium transmembrane transporter activity
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:0022804 ! active transmembrane transporter activity
relationship: part_of GO:0015839 ! cadaverine transport

[Term]
id: GO:0015491
name: cation:cation antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation A(out) + cation B(in) = cation A(in) + cation B(out)." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015298 ! solute:cation antiporter activity
is_a: GO:0099516 ! ion antiporter activity

[Term]
id: GO:0015492
name: phenylalanine:proton symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phenylalanine(out) + H+(out) = phenylalanine(in) + H+(in)." [TC:2.A.3.1.1]
synonym: "phenylalanine:hydrogen symporter activity" EXACT []
is_a: GO:0015192 ! L-phenylalanine transmembrane transporter activity
is_a: GO:0015494 ! aromatic amino acid:proton symporter activity

[Term]
id: GO:0015493
name: lysine:proton symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lysine(out) + H+(out) = lysine(in) + H+(in)." [TC:2.A.3.1.2]
synonym: "lysine:hydrogen symporter activity" EXACT []
is_a: GO:0005280 ! hydrogen:amino acid symporter activity
is_a: GO:0015189 ! L-lysine transmembrane transporter activity

[Term]
id: GO:0015494
name: aromatic amino acid:proton symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: aromatic amino acid(out) + H+(out) = aromatic amino acid(in) + H+(in)." [TC:2.A.3.1.3]
synonym: "aromatic amino acid:hydrogen symporter activity" EXACT []
is_a: GO:0005280 ! hydrogen:amino acid symporter activity
is_a: GO:0015173 ! aromatic amino acid transmembrane transporter activity

[Term]
id: GO:0015495
name: gamma-aminobutyric acid:proton symporter activity
namespace: molecular_function
alt_id: GO:0005331
alt_id: GO:0015329
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + H+(out) = gamma-aminobutyric acid(in) + H+(in)." [TC:2.A.18.5.1, TC:2.A.3.1.4, TC:2.A.3.4.2]
comment: See also the molecular function term 'neurotransmitter transporter activity ; GO:0005326'.
synonym: "4-aminobutanoate:hydrogen symporter activity" EXACT []
synonym: "4-aminobutanoate:proton symporter activity" EXACT []
synonym: "4-aminobutyrate:hydrogen symporter activity" EXACT []
synonym: "4-aminobutyrate:proton symporter activity" EXACT []
synonym: "GABA:hydrogen symporter activity" EXACT []
synonym: "GABA:proton symporter activity" EXACT []
synonym: "gamma-aminobutyric acid permease activity" EXACT []
synonym: "gamma-aminobutyric acid:hydrogen symporter activity" EXACT []
is_a: GO:0005280 ! hydrogen:amino acid symporter activity
is_a: GO:0015185 ! gamma-aminobutyric acid transmembrane transporter activity
is_a: GO:0015370 ! solute:sodium symporter activity

[Term]
id: GO:0015496
name: putrescine:ornithine antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: putrescine(out) + ornithine(in) = putrescine(in) + ornithine(out)." [TC:2.A.3.2.1]
subset: gosubset_prok
synonym: "putrescine-ornithine antiporter activity" EXACT []
synonym: "putrescine/ornithine antiporter activity" EXACT []
synonym: "putrescine:hydrogen symporter activity" EXACT []
is_a: GO:0000064 ! L-ornithine transmembrane transporter activity
is_a: GO:0015489 ! putrescine transmembrane transporter activity
is_a: GO:0015491 ! cation:cation antiporter activity

[Term]
id: GO:0015498
name: pantothenate:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: pantothenate(out) + Na+(out) = pantothenate(in) + Na+(in)." [TC:2.A.21.1.1]
subset: gosubset_prok
is_a: GO:0005343 ! organic acid:sodium symporter activity
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015233 ! pantothenate transmembrane transporter activity
is_a: GO:0015296 ! anion:cation symporter activity

[Term]
id: GO:0015499
name: formate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of formate from one side of the membrane to the other. Formate is also known as methanoate, the anion HCOO- derived from methanoic (formic) acid." [GOC:ai]
subset: gosubset_prok
xref: RHEA:29682
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
relationship: part_of GO:0015724 ! formate transport

[Term]
id: GO:0015500
name: obsolete threonine/serine:sodium symporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (threonine or serine)(out) + Na+(out) = (threonine or serine)(in) + Na+(in)." [TC:2.A.23.4.1]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "threonine/serine:sodium symporter activity" EXACT []
is_obsolete: true
consider: GO:0005283
consider: GO:0015194
consider: GO:0015195

[Term]
id: GO:0015501
name: glutamate:sodium symporter activity
namespace: molecular_function
alt_id: GO:0008027
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + Na+(out) = glutamate(in) + Na+(in)." [TC:2.A.27.1.1]
synonym: "sodium/excitatory glutamate cotransporter activity" BROAD []
synonym: "sodium/excitatory glutamate symporter activity" EXACT []
xref: RHEA:29034
is_a: GO:0005283 ! sodium:amino acid symporter activity
is_a: GO:0005313 ! L-glutamate transmembrane transporter activity
is_a: GO:0015296 ! anion:cation symporter activity

[Term]
id: GO:0015503
name: glutathione-regulated potassium exporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in), where glutathione maintains the closed state." [PMID:11053405, TC:2.A.37.1.1, TC:2.A.37.1.2]
subset: gosubset_prok
is_a: GO:0015079 ! potassium ion transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0015504
name: cytosine:hydrogen ion symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cytosine(out) + H+(out) = cytosine(in) + H+(in)." [TC:2.A.39.1.1]
synonym: "cytosine permease activity" RELATED []
is_a: GO:0015209 ! cytosine transmembrane transporter activity
is_a: GO:0015295 ! solute:proton symporter activity
is_a: GO:0015391 ! nucleobase:cation symporter activity

[Term]
id: GO:0015505
name: uracil:cation symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: uracil(out) + cation(out) = uracil(in) + cation(in)." [GOC:mtg_transport]
subset: gosubset_prok
synonym: "uracil permease activity" RELATED []
is_a: GO:0015210 ! uracil transmembrane transporter activity
is_a: GO:0015391 ! nucleobase:cation symporter activity

[Term]
id: GO:0015506
name: nucleoside:proton symporter activity
namespace: molecular_function
alt_id: GO:0015536
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleoside(out) + H+(out) = nucleoside(in) + H+(in)." [TC:2.A.1.10.1, TC:2.A.41.1.1]
synonym: "nucleoside permease activity" RELATED []
synonym: "nucleoside:hydrogen ion symporter activity" EXACT []
synonym: "nucleoside:hydrogen symporter activity" EXACT []
is_a: GO:0005337 ! nucleoside transmembrane transporter activity
is_a: GO:0015295 ! solute:proton symporter activity

[Term]
id: GO:0015507
name: obsolete hydroxy/aromatic amino acid permease activity
namespace: molecular_function
def: "OBSOLETE. Permease for hydroxy and aromatic amino acids." [GOC:ai]
comment: This term was made obsolete because it is a redundant grouping term.
synonym: "hydroxy/aromatic amino acid permease activity" EXACT []
is_obsolete: true
consider: GO:0015171
consider: GO:0015173

[Term]
id: GO:0015513
name: nitrite uptake transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of nitrite from the outside of a cell to the inside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729]
synonym: "nitrite uptake permease activity" EXACT []
is_a: GO:0015113 ! nitrite transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity
is_a: GO:0015563 ! uptake transmembrane transporter activity

[Term]
id: GO:0015514
name: nitrite efflux transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of nitrite from the inside of the cell to the outside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "nitrite extrusion permease activity" EXACT []
is_a: GO:0015113 ! nitrite transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity
is_a: GO:0015562 ! efflux transmembrane transporter activity

[Term]
id: GO:0015515
name: citrate:succinate antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: citrate(out) + succinate(in) = citrate(in) + succinate(out)." [TC:2.A.47.3.2]
subset: gosubset_prok
is_a: GO:0005371 ! tricarboxylate secondary active transmembrane transporter activity
is_a: GO:0015137 ! citrate transmembrane transporter activity
is_a: GO:0015141 ! succinate transmembrane transporter activity
is_a: GO:0015301 ! anion:anion antiporter activity

[Term]
id: GO:0015516
name: tartrate:succinate antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: tartrate(out) + succinate(in) = tartrate(in) + succinate(out)." [TC:2.A.47.3.3]
is_a: GO:0015141 ! succinate transmembrane transporter activity
is_a: GO:0015301 ! anion:anion antiporter activity
is_a: GO:0015554 ! tartrate transmembrane transporter activity

[Term]
id: GO:0015517
name: galactose:proton symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose(out) + H+(out) = galactose(in) + H+(in)." [TC:2.A.1.1.1, TC:2.A.1.1.9]
subset: gosubset_prok
synonym: "galactose:hydrogen symporter activity" EXACT []
synonym: "lactose, galactose:hydrogen symporter activity" BROAD []
is_a: GO:0005354 ! galactose transmembrane transporter activity
is_a: GO:0009679 ! hexose:proton symporter activity

[Term]
id: GO:0015518
name: arabinose:proton symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: arabinose(out) + H+(out) = arabinose(in) + H+(in)." [TC:2.A.1.1.2]
synonym: "arabinose:hydrogen symporter activity" EXACT []
is_a: GO:0005351 ! sugar:proton symporter activity
is_a: GO:0042900 ! arabinose transmembrane transporter activity

[Term]
id: GO:0015519
name: D-xylose:proton symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-xylose(out) + H+(out) = D-xylose(in) + H+(in)." [TC:2.A.1.1.3]
subset: gosubset_prok
synonym: "D-xylose:hydrogen symporter activity" EXACT []
is_a: GO:0005351 ! sugar:proton symporter activity
is_a: GO:0015148 ! D-xylose transmembrane transporter activity

[Term]
id: GO:0015520
name: tetracycline:proton antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out)." [TC:2.A.1.2.4]
subset: gosubset_prok
synonym: "tetracyclin:hydrogen antiporter activity" EXACT []
synonym: "tetracyclin:proton antiporter activity" EXACT []
synonym: "tetracycline:hydrogen antiporter activity" EXACT []
is_a: GO:0008493 ! tetracycline transporter activity
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015307 ! drug:proton antiporter activity
is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity

[Term]
id: GO:0015521
name: obsolete bicyclomycin/sulfathiazole:hydrogen antiporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (bicyclomycin or sulfathiazole)(in) + H+(out) = (bicyclomycin or sulfathiazole)(out) + H+(in)." [TC:2.A.1.2.7]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "bicyclomycin/sulfathiazole:hydrogen antiporter activity" EXACT []
synonym: "bicyclomycin/sulfathiazole:proton antiporter activity" EXACT []
synonym: "bicyclomycin/sulphathiazole:hydrogen antiporter activity" EXACT []
is_obsolete: true
consider: GO:0015545
consider: GO:0015546
consider: GO:0045119

[Term]
id: GO:0015522
name: hydrophobic uncoupler:proton antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hydrophobic uncoupler(in) + H+(out) = hydrophobic uncoupler(out) + H+(in). Hydrophobic uncouplers include CCCP, benzalkonium and SDS." [TC:2.A.1.2.9]
synonym: "hydrophobic uncoupler:hydrogen antiporter activity" EXACT []
is_a: GO:0015307 ! drug:proton antiporter activity
is_a: GO:0017077 ! oxidative phosphorylation uncoupler activity

[Term]
id: GO:0015523
name: arabinose efflux transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of arabinose from the inside of the cell to the outside of the cell across a membrane: H+(out) + arabinose(in) = H+(in) + arabinose(out)." [GOC:mtg_transport, ISBN:0815340729, TC:2.A.1.2.14]
synonym: "arabinose efflux permease activity" EXACT []
is_a: GO:0005351 ! sugar:proton symporter activity
is_a: GO:0015562 ! efflux transmembrane transporter activity
is_a: GO:0042900 ! arabinose transmembrane transporter activity

[Term]
id: GO:0015524
name: obsolete L-arabinose/beta-D-thiogalactopyranoside:hydrogen antiporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H+(out) + (L-arabinose or beta-D-thiogalactopyranoside)(in) = H+(in) + (L-arabinose or beta-D-thiogalactopyranoside)(out)." [TC:2.A.1.2.15]
comment: This term was made obsolete because it represents a gene product rather than a single discrete molecular function.
synonym: "L-arabinose/beta-D-thiogalactopyranoside:hydrogen antiporter activity" EXACT []
synonym: "L-arabinose/beta-D-thiogalactopyranoside:proton antiporter activity" EXACT []
is_obsolete: true
consider: GO:0015147
consider: GO:0015299
consider: GO:0051119

[Term]
id: GO:0015525
name: obsolete carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity" EXACT []
synonym: "carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:proton antiporter activity" EXACT []
is_obsolete: true
consider: GO:0015307
consider: GO:0015547
consider: GO:0015548
consider: GO:0015549

[Term]
id: GO:0015526
name: hexose-phosphate:inorganic phosphate antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose phosphate(out) + inorganic phosphate(in) = hexose phosphate(in) + inorganic phosphate(out)." [TC:2.A.1.4.1]
is_a: GO:0015119 ! hexose phosphate transmembrane transporter activity
is_a: GO:0015315 ! organophosphate:inorganic phosphate antiporter activity

[Term]
id: GO:0015527
name: glycerol-phosphate:inorganic phosphate antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycerol phosphate(out) + inorganic phosphate(in) = glycerol phosphate(in) + inorganic phosphate(out)." [TC:2.A.1.4.3]
is_a: GO:0015168 ! glycerol transmembrane transporter activity
is_a: GO:0015315 ! organophosphate:inorganic phosphate antiporter activity

[Term]
id: GO:0015528
name: lactose:proton symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lactose(out) + H+(out) = lactose(in) + H+(in)." [TC:2.A.1.1.9, TC:2.A.1.5.1]
synonym: "lactose, galactose:hydrogen symporter activity" BROAD []
synonym: "lactose:hydrogen symporter activity" EXACT []
is_a: GO:0005351 ! sugar:proton symporter activity
is_a: GO:0015155 ! lactose transmembrane transporter activity

[Term]
id: GO:0015529
name: raffinose:proton symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: raffinose(out) + H+(out) = raffinose(in) + H+(in)." [TC:2.A.1.5.2]
synonym: "raffinose:hydrogen symporter activity" EXACT []
is_a: GO:0005351 ! sugar:proton symporter activity
is_a: GO:0015158 ! raffinose transmembrane transporter activity

[Term]
id: GO:0015530
name: shikimate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of shikimate from one side of the membrane to the other. Shikimate is an important intermediate in the biosynthesis of aromatic amino acids." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity
relationship: part_of GO:0015733 ! shikimate transport

[Term]
id: GO:0015531
name: citrate:proton symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: citrate(out) + H+(out) = citrate(in) + H+(in)." [TC:2.A.1.6.1]
synonym: "citrate:hydrogen symporter activity" EXACT []
xref: RHEA:32126
is_a: GO:0005371 ! tricarboxylate secondary active transmembrane transporter activity
is_a: GO:0015137 ! citrate transmembrane transporter activity
is_a: GO:0015295 ! solute:proton symporter activity

[Term]
id: GO:0015532
name: alpha-ketoglutarate:proton symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alpha-ketoglutarate(out) + H+(out) = alpha-ketoglutarate(in) + H+(in)." [TC:2.A.1.6.2]
subset: gosubset_prok
synonym: "2-oxoglutarate:hydrogen symporter activity" EXACT []
synonym: "2-oxoglutarate:proton symporter activity" EXACT []
synonym: "alpha-ketoglutarate:hydrogen symporter activity" EXACT []
is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity
is_a: GO:0015139 ! alpha-ketoglutarate transmembrane transporter activity
is_a: GO:0015295 ! solute:proton symporter activity
is_a: GO:0015296 ! anion:cation symporter activity

[Term]
id: GO:0015533
name: shikimate:proton symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: shikimate(out) + H+(out) = shikimate(in) + H+(in)." [TC:2.A.1.6.6]
synonym: "shikimate:hydrogen symporter activity" EXACT []
is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity
is_a: GO:0015295 ! solute:proton symporter activity
is_a: GO:0015296 ! anion:cation symporter activity
is_a: GO:0015530 ! shikimate transmembrane transporter activity

[Term]
id: GO:0015534
name: obsolete proline/glycine/betaine:hydrogen/sodium symporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (proline, glycine or betaine)(out) + (H+ or Na+)(out) = (proline, glycine or betaine)(in) + (H+ or Na+)(in)." [TC:2.A.1.6.4]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" EXACT []
synonym: "proline/glycine/betaine:proton/sodium symporter" EXACT []
is_obsolete: true
consider: GO:0015187
consider: GO:0015193
consider: GO:0015199
consider: GO:0015294
consider: GO:0015295
consider: GO:0015370

[Term]
id: GO:0015535
name: fucose:proton symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: fucose(out) + H+(out) = fucose(in) + H+(in)." [TC:2.A.1.7.1]
synonym: "fucose:hydrogen symporter activity" EXACT []
xref: RHEA:29026
is_a: GO:0009679 ! hexose:proton symporter activity
is_a: GO:0015150 ! fucose transmembrane transporter activity

[Term]
id: GO:0015537
name: xanthosine:hydrogen ion symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: xanthosine(out) + H+(out) = xanthosine(in) + H+(in)." [TC:2.A.1.10.2]
synonym: "xanthosine permease activity" RELATED []
is_a: GO:0015506 ! nucleoside:proton symporter activity
is_a: GO:0015553 ! xanthosine transmembrane transporter activity

[Term]
id: GO:0015538
name: sialic acid:proton symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sialate(out) + H+(out) = sialate(in) + H+(in)." [TC:2.A.1.12.1]
subset: gosubset_prok
synonym: "sialic acid permease activity" RELATED []
synonym: "sialic acid:hydrogen symporter activity" EXACT []
xref: Reactome:REACT_112212 "Proton-coupled sialic acid co-transport, Escherichia coli"
xref: Reactome:REACT_112268 "Proton-coupled sialic acid co-transport, Caenorhabditis elegans"
xref: Reactome:REACT_113008 "Proton-coupled sialic acid co-transport, Xenopus tropicalis"
xref: Reactome:REACT_113908 "Proton-coupled sialic acid co-transport, Arabidopsis thaliana"
xref: Reactome:REACT_114194 "Proton-coupled sialic acid co-transport, Oryza sativa"
xref: Reactome:REACT_114441 "Proton-coupled sialic acid co-transport, Staphylococcus aureus N315"
xref: Reactome:REACT_19297 "Proton-coupled sialic acid co-transport, Homo sapiens"
xref: Reactome:REACT_28435 "Proton-coupled sialic acid co-transport, Rattus norvegicus"
xref: Reactome:REACT_29002 "Proton-coupled sialic acid co-transport, Danio rerio"
xref: Reactome:REACT_31104 "Proton-coupled sialic acid co-transport, Mus musculus"
xref: Reactome:REACT_77770 "Proton-coupled sialic acid co-transport, Bos taurus"
xref: Reactome:REACT_79115 "Proton-coupled sialic acid co-transport, Canis familiaris"
xref: Reactome:REACT_87695 "Proton-coupled sialic acid co-transport, Gallus gallus"
xref: Reactome:REACT_88095 "Proton-coupled sialic acid co-transport, Sus scrofa"
xref: Reactome:REACT_91063 "Proton-coupled sialic acid co-transport, Taeniopygia guttata"
is_a: GO:0015136 ! sialic acid transmembrane transporter activity
is_a: GO:0015295 ! solute:proton symporter activity

[Term]
id: GO:0015539
name: hexuronate:cation symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexuronate(out) + cation(out) = hexuronate(in) + cation(in). The hexuronate may be glucuronate or galacturonate." [TC:2.A.1.14.2]
synonym: "hexuronate (glucuronate/galacturonate) porter activity" NARROW []
synonym: "hexuronate porter activity" RELATED []
is_a: GO:0005351 ! sugar:proton symporter activity
is_a: GO:0015134 ! hexuronate transmembrane transporter activity
is_a: GO:0015296 ! anion:cation symporter activity

[Term]
id: GO:0015540
name: 3-hydroxyphenyl propionate:hydrogen ion symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 3-hydroxyphenyl propionate(out) + H+(out) = 3-hydroxyphenyl propionate(in) + H+(in)." [TC:2.A.1.15.2]
synonym: "3-hydroxyphenyl propionate porter activity" RELATED []
is_a: GO:0015293 ! symporter activity
is_a: GO:0015551 ! 3-hydroxyphenyl propanoate transmembrane transporter activity

[Term]
id: GO:0015541
name: secondary active cyanate uptake transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cyanate(out) = cyanate(in)." [TC:2.A.1.17.1]
synonym: "cyanate porter activity" RELATED []
is_a: GO:0015110 ! cyanate transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0015542
name: sugar efflux transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(in) = sugar(out)." [GOC:mtg_transport, ISBN:0815340729, TC:2.A.1.20.1]
subset: gosubset_prok
synonym: "lactose/glucose efflux transporter activity" NARROW []
is_a: GO:0005351 ! sugar:proton symporter activity

[Term]
id: GO:0015543
name: obsolete lactose/glucose efflux transporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: glucose or lactose(in) = glucose or lactose(out)." [TC:2.A.1.20.2]
comment: This term was made obsolete because it represents two molecular functions.
synonym: "lactose/glucose efflux transporter activity" EXACT []
is_obsolete: true
consider: GO:0005355
consider: GO:0015155
consider: GO:0015542

[Term]
id: GO:0015544
name: phenyl propionate uptake uniporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phenyl propionate(out) = phenyl propionate(in)." [GOC:mtg_transport, TC:2.A.1.27.1]
synonym: "phenyl propionate permease activity" RELATED []
is_a: GO:0015291 ! secondary active transmembrane transporter activity
is_a: GO:0015552 ! propionate transmembrane transporter activity

[Term]
id: GO:0015545
name: bicyclomycin transporter activity
namespace: molecular_function
def: "Enables the directed movement of bicyclomycin into, out of or within a cell, or between cells. Bicyclomycin (or bicozamycin) is an antibacterial drug often used as a livestock feed additive." [ISBN:91191028X]
subset: gosubset_prok
synonym: "bicyclomycin/sulfathiazole:hydrogen antiporter activity" RELATED []
is_a: GO:0042895 ! antibiotic transporter activity
relationship: part_of GO:0015905 ! bicyclomycin transport

[Term]
id: GO:0015546
name: sulfathiazole transmembrane transporter activity
namespace: molecular_function
def: "Enables the directed movement of sulfathiazole across a membrane. Sulfathiazole is an antibacterial agent of the sulfonamide group." [CHEBI:9337, GOC:curators]
synonym: "bicyclomycin/sulfathiazole:hydrogen antiporter activity" RELATED []
synonym: "sulphathiazole transporter activity" EXACT []
is_a: GO:0042887 ! amide transmembrane transporter activity
is_a: GO:1901474 ! azole transmembrane transporter activity
is_a: GO:1901682 ! sulfur compound transmembrane transporter activity
relationship: part_of GO:1902599 ! sulfathiazole transmembrane transport

[Term]
id: GO:0015547
name: nalidixic acid transporter activity
namespace: molecular_function
def: "Enables the directed movement of nalidixic acid into, out of or within a cell, or between cells. Nalidixic acid is a synthetic antibiotic that interferes with DNA gyrase and inhibits prokaryotic replication." [GOC:curators, PMID:12702699, PubChem_Compound:4221]
synonym: "carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity" RELATED []
is_a: GO:0042895 ! antibiotic transporter activity
is_a: GO:0042910 ! xenobiotic transporter activity
relationship: part_of GO:0015896 ! nalidixic acid transport

[Term]
id: GO:0015548
name: organomercurial transporter activity
namespace: molecular_function
def: "Enables the directed movement of organomercurial compounds into, out of or within a cell, or between cells. Organomercurial substances are any organic compound containing a mercury atom." [GOC:ai]
synonym: "carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity" RELATED []
is_a: GO:0090484 ! drug transporter activity
relationship: part_of GO:0015897 ! organomercurial transport

[Term]
id: GO:0015549
name: carbonyl cyanide m-chlorophenylhydrazone transporter activity
namespace: molecular_function
def: "Enables the directed movement of carbonyl cyanide m-chlorophenylhydrazone into, out of or within a cell, or between cells. Carbonyl cyanide m-chlorophenylhydrazone is a proton ionophore, commonly used as an uncoupling agent and inhibitor of photosynthesis because of its effects on mitochondrial and chloroplast membranes." [CHEBI:3259, GOC:curators]
synonym: "carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity" RELATED []
synonym: "CCCP transporter activity" EXACT []
is_a: GO:0090484 ! drug transporter activity
relationship: part_of GO:0015902 ! carbonyl cyanide m-chlorophenylhydrazone transport

[Term]
id: GO:0015550
name: galacturonate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of galacturonate from one side of the membrane to the other. Galacturonate is the uronic acid formally derived from galactose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group." [GOC:ai]
is_a: GO:0015134 ! hexuronate transmembrane transporter activity
relationship: part_of GO:0015737 ! galacturonate transport

[Term]
id: GO:0015551
name: 3-hydroxyphenyl propanoate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of 3-hydroxyphenyl propanoate from one side of the membrane to the other." [GOC:ai]
synonym: "3-hydroxyphenyl propionate transmembrane transporter activity" EXACT []
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity
is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity
relationship: part_of GO:0015731 ! 3-hydroxyphenyl propanoate transport

[Term]
id: GO:0015552
name: propionate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of propionate from one side of the membrane to the other. Propionate (or propanoate) is the organic acid CH3-CH2-COOH." [GOC:ai]
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:0015635 ! short-chain fatty acid transporter activity
relationship: part_of GO:0015730 ! propanoate transport

[Term]
id: GO:0015553
name: xanthosine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of xanthosine, xanthine riboside, from one side of a membrane to the other." [ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0015211 ! purine nucleoside transmembrane transporter activity
relationship: part_of GO:0015863 ! xanthosine transport

[Term]
id: GO:0015554
name: tartrate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of tartrate from one side of the membrane to the other. Tartrate is the anion of 2,3-dihydroxybutanedioic acid, one of the aldaric acids. The L(+) enantiomer occurs widely in plants, especially in grape juice, and in fungi and bacteria." [GOC:ai]
subset: gosubset_prok
is_a: GO:1901702 ! salt transmembrane transporter activity

[Term]
id: GO:0015556
name: C4-dicarboxylate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of C4-dicarboxylate from one side of the membrane to the other." [GOC:krc]
subset: gosubset_prok
is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity
relationship: part_of GO:0015740 ! C4-dicarboxylate transport

[Term]
id: GO:0015557
name: arginine targeting transmembrane transporter activity
namespace: molecular_function
def: "Enables the directed movement of fully folded proteins into, out of or within a cell, or between cells, by targeting the proteins to the transporter via a specialized N-terminal twin arginine signal peptide." [GOC:dph, GOC:tb, PMID:17956229]
is_a: GO:0008320 ! protein transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0015558
name: p-aminobenzoyl-glutamate uptake transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of p-aminobenzoyl-glutamate from the outside of a cell to the inside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729]
synonym: "p-aminobenzoyl-glutamate uptake permease activity" EXACT []
is_a: GO:0015563 ! uptake transmembrane transporter activity
is_a: GO:0015569 ! p-aminobenzoyl-glutamate transmembrane transporter activity

[Term]
id: GO:0015560
name: obsolete L-idonate/D-gluconate:hydrogen symporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (L-idonate or D-gluconate)(out) + H+(out) = (L-iodonate or D-gluconate)(in) + H+(in)." [TC:2.A.8.1.2]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "L-idonate/D-gluconate:hydrogen symporter activity" EXACT []
synonym: "L-idonate/D-gluconate:proton symporter" EXACT []
is_obsolete: true
consider: GO:0015128
consider: GO:0015295
consider: GO:0015568

[Term]
id: GO:0015561
name: rhamnose:proton symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: rhamnose(out) + H+(out) = rhamnose(in) + H+(in)." [TC:2.A.7.6.1]
synonym: "rhamnose:hydrogen symporter activity" EXACT []
is_a: GO:0009679 ! hexose:proton symporter activity
is_a: GO:0015153 ! rhamnose transmembrane transporter activity

[Term]
id: GO:0015562
name: efflux transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "efflux permease activity" EXACT []
synonym: "monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity" RELATED []
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0015563
name: uptake transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a specific substance or related group of substances from the outside of a cell to the inside across a membrane." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "cobalt, zinc uptake permease activity" RELATED []
synonym: "monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity" RELATED []
synonym: "uptake permease activity" RELATED []
synonym: "zinc, cadmium uptake permease activity" NARROW []
synonym: "zinc, iron permease activity" NARROW []
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0015565
name: threonine efflux transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of threonine from the inside of the cell to the outside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729]
synonym: "threonine efflux permease activity" EXACT []
synonym: "threonine export protein" RELATED []
synonym: "threonine export transporter activity" EXACT []
is_a: GO:0015195 ! L-threonine transmembrane transporter activity
is_a: GO:0034639 ! L-amino acid efflux transmembrane transporter activity

[Term]
id: GO:0015566
name: acriflavine transporter activity
namespace: molecular_function
alt_id: GO:0015555
def: "Enables the directed movement of acriflavin into, out of or within a cell, or between cells. Acriflavin is a fluorescent dye used as a local antiseptic and also as a biological stain. It intercalates into nucleic acids thereby inhibiting bacterial and viral replication." [PubChem_Compound:6842]
synonym: "acriflavin resistant pump activity" RELATED [GOC:dph, GOC:tb]
synonym: "acriflavin transporter activity" EXACT [GOC:dph, GOC:tb]
is_a: GO:0042910 ! xenobiotic transporter activity
is_a: GO:0090484 ! drug transporter activity
relationship: part_of GO:0015894 ! acriflavine transport

[Term]
id: GO:0015567
name: alkane transporter activity
namespace: molecular_function
def: "Enables the directed movement of alkanes into, out of or within a cell, or between cells. Alkanes are saturated aliphatic hydrocarbon compounds." [GOC:ai]
is_a: GO:0005215 ! transporter activity
relationship: part_of GO:0015895 ! alkane transport

[Term]
id: GO:0015568
name: L-idonate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of L-idonate from one side of the membrane to the other. L-idonate is an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose." [GOC:ai]
subset: gosubset_prok
synonym: "L-idonate/D-gluconate:hydrogen symporter activity" NARROW []
is_a: GO:0042879 ! aldonate transmembrane transporter activity
relationship: part_of GO:0015726 ! L-idonate transport

[Term]
id: GO:0015569
name: p-aminobenzoyl-glutamate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of p-aminobenzoyl-glutamate from one side of a membrane to the other. p-aminobenzoyl-glutamate is the anion of p-aminobenzoyl-glutamic acid." [GOC:ai]
subset: gosubset_prok
synonym: "p-aminobenzoyl-glutamate transporter activity" BROAD []
is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity
is_a: GO:0071916 ! dipeptide transmembrane transporter activity
is_a: GO:0072349 ! modified amino acid transmembrane transporter activity
relationship: part_of GO:1902604 ! p-aminobenzoyl-glutamate transmembrane transport

[Term]
id: GO:0015571
name: N-acetylgalactosamine transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015590
def: "Enables the transfer of N-acetylgalactosamine from one side of the membrane to the other. N-acetylgalactosamine, 2-acetamido-2-deoxygalactopyranose, is the n-acetyl derivative of galactosamine." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "N-acetylgalactosamine permease activity" EXACT []
is_a: GO:0019196 ! galactosamine transmembrane transporter activity
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity
relationship: part_of GO:0015763 ! N-acetylgalactosamine transport

[Term]
id: GO:0015572
name: N-acetylglucosamine transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015580
def: "Enables the transfer of N-acetylglucosamine from one side of the membrane to the other. The D isomer of N-acetylglucosamine is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "D-GlcNAc transmembrane transporter activity" EXACT []
synonym: "N-Acetyl-D-glucosamine permease" RELATED []
synonym: "N-acetyl-D-glucosamine transmembrane transporter activity" EXACT []
synonym: "N-acetylchitosamine transmembrane transporter activity" EXACT []
synonym: "N-acetylglucosamine permease activity" RELATED []
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity
is_a: GO:1901505 ! carbohydrate derivative transporter activity

[Term]
id: GO:0015573
name: beta-glucoside transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015582
def: "Enables the transfer of beta-glucosides from one side of the membrane to the other. Beta-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in a beta configuration." [GOC:jl, GOC:mtg_transport, http://www.biochem.purdue.edu/, ISBN:0198506732, ISBN:0815340729]
subset: gosubset_prok
synonym: "beta-glucoside permease activity" EXACT []
is_a: GO:0042947 ! glucoside transmembrane transporter activity
relationship: part_of GO:0015759 ! beta-glucoside transport

[Term]
id: GO:0015574
name: trehalose transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015584
def: "Enables the transfer of trehalose from one side of the membrane to the other. Trehalose is the disaccharide alpha-D-glucopyranosyl-alpha-D-glucopyranoside that acts of a reserve carbohydrate in certain fungi, algae and lichens." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
subset: gosubset_prok
synonym: "trehalose permease activity" EXACT []
is_a: GO:0015151 ! alpha-glucoside transmembrane transporter activity
is_a: GO:0015154 ! disaccharide transmembrane transporter activity
relationship: part_of GO:0015771 ! trehalose transport

[Term]
id: GO:0015575
name: mannitol transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015586
def: "Enables the transfer of mannitol from one side of the membrane to the other. Mannitol is the alditol derived from D-mannose by reduction of the aldehyde group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "mannitol permease activity" EXACT []
is_a: GO:0015144 ! carbohydrate transmembrane transporter activity
is_a: GO:0015166 ! polyol transmembrane transporter activity
relationship: part_of GO:0015797 ! mannitol transport

[Term]
id: GO:0015576
name: sorbitol transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015587
def: "Enables the transfer of sorbitol from one side of the membrane to the other. Sorbitol, also known as glucitol, is the hexitol derived by the reduction of the aldehyde group of glucose." [GOC:ai, ISBN:0198506732]
subset: gosubset_prok
synonym: "glucitol permease activity" EXACT []
synonym: "glucitol transporter activity" EXACT []
synonym: "sorbitol permease activity" EXACT []
is_a: GO:0015144 ! carbohydrate transmembrane transporter activity
is_a: GO:0015166 ! polyol transmembrane transporter activity
is_a: GO:0022804 ! active transmembrane transporter activity
relationship: part_of GO:0015795 ! sorbitol transport

[Term]
id: GO:0015577
name: galactitol transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015588
def: "Enables the transfer of a galactitol from one side of the membrane to the other. Galactitol is the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "galactitol permease activity" EXACT []
xref: RHEA:33146
is_a: GO:0015144 ! carbohydrate transmembrane transporter activity
is_a: GO:0015166 ! polyol transmembrane transporter activity
relationship: part_of GO:0015796 ! galactitol transport

[Term]
id: GO:0015578
name: mannose transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015589
def: "Enables the transfer of mannose from one side of the membrane to the other. Mannose is the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "mannose permease activity" EXACT []
is_a: GO:0015149 ! hexose transmembrane transporter activity
relationship: part_of GO:0015761 ! mannose transport

[Term]
id: GO:0015583
name: obsolete beta-glucoside [arbutin-salicin-cellobiose] permease activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: protein N-phosphohistidine + beta-glucoside(out) = protein histidine + beta-glucoside phosphate(in). The beta-glucoside may be arbutin, salicin or cellobiose." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
comment: This term was made obsolete because it arbitrarily groups three substrates.
synonym: "beta-glucoside [arbutin-salicin-cellobiose] permease activity" EXACT []
is_obsolete: true

[Term]
id: GO:0015591
name: D-ribose transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of D-ribose from one side of the membrane to the other. As beta-D-ribofuranose, D-ribose forms the glycose group of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0015146 ! pentose transmembrane transporter activity
relationship: part_of GO:0015752 ! D-ribose transport

[Term]
id: GO:0015592
name: methylgalactoside transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of methylgalactoside from one side of the membrane to the other. Methylgalactoside is a compound in which the H of the OH group on carbon-1 of galactose is replaced by a methyl group." [CHEBI:55507, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "galactose/glucose (methylgalactoside) porter activity" RELATED []
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity
is_a: GO:1901505 ! carbohydrate derivative transporter activity
relationship: part_of GO:0015765 ! methylgalactoside transport

[Term]
id: GO:0015593
name: allose transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of allose from one side of the membrane to the other. Allose is an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0015149 ! hexose transmembrane transporter activity
relationship: part_of GO:0015754 ! allose transport

[Term]
id: GO:0015594
name: putrescine-importing ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O + putrescine(out) -> ADP + phosphate + putrescine(in)." [EC:3.6.3.31]
synonym: "putrescine porter activity" BROAD []
xref: RHEA:29998
is_a: GO:0015417 ! polyamine-transporting ATPase activity
is_a: GO:0015489 ! putrescine transmembrane transporter activity
is_a: GO:0019829 ! cation-transporting ATPase activity

[Term]
id: GO:0015595
name: spermidine-importing ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O + spermidine(out) -> ADP + phosphate + spermidine(in)." [EC:3.6.3.31]
synonym: "spermidine porter activity" BROAD []
xref: MetaCyc:ABC-24-RXN
xref: RHEA:30002
is_a: GO:0015417 ! polyamine-transporting ATPase activity
is_a: GO:0015606 ! spermidine transmembrane transporter activity
is_a: GO:0019829 ! cation-transporting ATPase activity

[Term]
id: GO:0015596
name: obsolete glycine betaine/proline porter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + quaternary amine(out) = ADP + phosphate + quaternary amine(in)." [EC:3.6.3.32, TC:3.A.1.12.1]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "glycine betaine/proline porter activity" EXACT []
is_obsolete: true
consider: GO:0015187
consider: GO:0015193
consider: GO:0015199
consider: GO:0015418

[Term]
id: GO:0015597
name: obsolete histidine/arginine/lysine/ornithine porter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in)." [EC:3.6.3.21, TC:3.A.1.3.1]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "histidine/arginine/lysine/ornithine porter activity" EXACT []
is_obsolete: true
consider: GO:0000064
consider: GO:0005290
consider: GO:0015181
consider: GO:0015189
consider: GO:0015426

[Term]
id: GO:0015598
name: arginine-importing ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + arginine(out) -> ADP + phosphate + arginine(in)." [EC:3.6.3.21]
subset: gosubset_prok
synonym: "arginine porter activity" EXACT []
is_a: GO:0015181 ! arginine transmembrane transporter activity
is_a: GO:0015426 ! polar-amino acid-transporting ATPase activity
is_a: GO:0019829 ! cation-transporting ATPase activity
relationship: part_of GO:0090467 ! arginine import

[Term]
id: GO:0015599
name: glutamine-importing ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + glutamine(out) -> ADP + phosphate + glutamine(in)." [EC:3.6.3.21]
subset: gosubset_prok
synonym: "glutamine porter activity" BROAD []
xref: MetaCyc:ABC-12-RXN
is_a: GO:0015186 ! L-glutamine transmembrane transporter activity
is_a: GO:0015426 ! polar-amino acid-transporting ATPase activity
is_a: GO:0019829 ! cation-transporting ATPase activity
relationship: part_of GO:0036229 ! L-glutamine import

[Term]
id: GO:0015600
name: obsolete glutamate/aspartate porter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in)." [EC:3.6.3.21, TC:3.A.1.3.4]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "glutamate/aspartate porter activity" EXACT []
is_obsolete: true
consider: GO:0005313
consider: GO:0015183
consider: GO:0015426

[Term]
id: GO:0015601
name: obsolete cystine/diaminopimelate porter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in)." [EC:3.6.3.21, TC:3.A.1.3.10]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "cystine/diaminopimelate porter activity" EXACT []
is_obsolete: true
consider: GO:0015184
consider: GO:0015426
consider: GO:0015626

[Term]
id: GO:0015602
name: obsolete leucine/isoleucine/valine porter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + nonpolar amino acid(out) = ADP + phosphate + nonpolar amino acid(in)." [EC:3.6.3.22, TC:3.A.1.4.1]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "leucine/isoleucine/valine porter activity" EXACT []
is_obsolete: true
consider: GO:0005304
consider: GO:0015188
consider: GO:0015190
consider: GO:0015425

[Term]
id: GO:0015603
name: iron chelate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of an iron chelate from one side of a membrane to the other. An iron chelate is a heterocyclic compound having a metal ion attached by coordinate bonds to at least two nonmetal ions." [http://www.onelook.com]
subset: gosubset_prok
is_a: GO:0022857 ! transmembrane transporter activity
relationship: part_of GO:0015688 ! iron chelate transport

[Term]
id: GO:0015604
name: organic phosphonate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of phosphonate from one side of a membrane to the other. A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2)." [GOC:ai]
subset: gosubset_prok
is_a: GO:0022857 ! transmembrane transporter activity
relationship: part_of GO:0015716 ! organic phosphonate transport

[Term]
id: GO:0015605
name: organophosphate ester transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of organophosphate esters from one side of a membrane to the other. Organophosphate esters are small organic molecules containing phosphate ester bonds." [GOC:mcc]
is_a: GO:1901677 ! phosphate transmembrane transporter activity
relationship: part_of GO:0015748 ! organophosphate ester transport

[Term]
id: GO:0015606
name: spermidine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of spermidine, N-(3-aminopropyl)-1,4-diaminobutane, from one side of the membrane to the other." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008519 ! ammonium transmembrane transporter activity
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:0015203 ! polyamine transmembrane transporter activity
relationship: part_of GO:1903711 ! spermidine transmembrane transport

[Term]
id: GO:0015607
name: fatty-acyl-CoA transporter activity
namespace: molecular_function
def: "Enables the directed movement of a fatty acyl CoA group into, out of or within a cell, or between cells. A fatty acyl CoA group is any acyl group derived from a fatty acid with a coenzyme A group attached to it." [GOC:ai]
synonym: "fatty acyl CoA transporter activity" EXACT [GOC:curators]
is_a: GO:0005215 ! transporter activity
relationship: part_of GO:0015916 ! fatty-acyl-CoA transport

[Term]
id: GO:0015608
name: carbohydrate-importing ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + carbohydrate(out) -> ADP + phosphate + carbohydrate(in)." [GOC:ai, TC:3.A.1.1.-, TC:3.A.1.2.-]
subset: gosubset_prok
synonym: "carbohydrate uptake transporter activity" EXACT []
synonym: "sugar transporter" NARROW []
is_a: GO:0043211 ! carbohydrate-transporting ATPase activity

[Term]
id: GO:0015609
name: maltooligosaccharide-importing ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + maltooligosaccharide(out) -> ADP + phosphate + maltooligosaccharide(in)." [TC:3.A.1.-.-]
synonym: "maltooligosaccharide porter activity" BROAD []
is_a: GO:0015157 ! oligosaccharide transmembrane transporter activity
is_a: GO:0015608 ! carbohydrate-importing ATPase activity

[Term]
id: GO:0015610
name: glycerol phosphate-importing ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + glycerol-phosphate(out) -> ADP + phosphate + glycerol-phosphate(in)." [TC:3.A.1.-.-]
synonym: "glycerol-phosphate porter activity" BROAD []
is_a: GO:0015169 ! glycerol-3-phosphate transmembrane transporter activity
is_a: GO:0015608 ! carbohydrate-importing ATPase activity

[Term]
id: GO:0015611
name: D-ribose-importing ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-ribose(out) -> ADP + phosphate + D-ribose(in)." [EC:3.6.3.17, TC:3.A.1.-.-]
subset: gosubset_prok
synonym: "D-ribose porter activity" BROAD []
xref: MetaCyc:ABC-28-RXN
is_a: GO:0015407 ! monosaccharide-transporting ATPase activity
is_a: GO:0015591 ! D-ribose transmembrane transporter activity
is_a: GO:0015608 ! carbohydrate-importing ATPase activity

[Term]
id: GO:0015612
name: L-arabinose-importing ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + L-arabinose(out) -> ADP + phosphate + L-arabinose(in)." [EC:3.6.3.17, TC:3.A.1.-.-]
synonym: "L-arabinose porter activity" EXACT []
xref: MetaCyc:ABC-2-RXN
is_a: GO:0015147 ! L-arabinose transmembrane transporter activity
is_a: GO:0015407 ! monosaccharide-transporting ATPase activity
is_a: GO:0015608 ! carbohydrate-importing ATPase activity

[Term]
id: GO:0015613
name: obsolete galactose/glucose (methylgalactoside) porter activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "galactose/glucose (methylgalactoside) porter activity" EXACT []
is_obsolete: true
consider: GO:0005354
consider: GO:0005355
consider: GO:0015291
consider: GO:0015592

[Term]
id: GO:0015614
name: D-xylose-importing ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-xylose(out) -> ADP + phosphate + D-xylose(in)." [TC:3.A.1.-.-]
synonym: "D-xylose porter activity" BROAD []
xref: RHEA:29902
is_a: GO:0015148 ! D-xylose transmembrane transporter activity
is_a: GO:0015407 ! monosaccharide-transporting ATPase activity
is_a: GO:0015608 ! carbohydrate-importing ATPase activity

[Term]
id: GO:0015615
name: D-allose-importing ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-allose(out) -> ADP + phosphate + D-allose(in)." [TC:3.A.1.-.-]
synonym: "D-allose porter activity" BROAD []
is_a: GO:0015407 ! monosaccharide-transporting ATPase activity
is_a: GO:0015593 ! allose transmembrane transporter activity
is_a: GO:0015608 ! carbohydrate-importing ATPase activity

[Term]
id: GO:0015616
name: DNA translocase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive movement along a single- or double-stranded DNA molecule." [GOC:mah, PMID:16428451, PMID:17631491]
comment: Note that some gene products that possess DNA translocase activity, such as members of the FtsK/SpoIIIE family, can be fixed in place by interactions with other components of the cell; the relative movement between the protein and DNA bound to it results in movement of the DNA within the cell, often across a membrane.
is_a: GO:0008094 ! DNA-dependent ATPase activity
relationship: has_part GO:0003677 ! DNA binding

[Term]
id: GO:0015617
name: obsolete pilin/fimbrilin exporter activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "pilin/fimbrilin exporter activity" EXACT []
is_obsolete: true
consider: GO:0015462

[Term]
id: GO:0015619
name: thiamine pyrophosphate-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + thiamine pyrophosphate(out) = ADP + phosphate + thiamine pyrophosphate(in)." [TC:3.A.1.19.1]
synonym: "thiamin pyrophosphate ABC transporter" NARROW []
synonym: "thiamin pyrophosphate porter activity" BROAD []
synonym: "thiamin pyrophosphate transporting ATPase activity" EXACT [GOC:curators]
synonym: "TPP transporting ATPase activity" EXACT []
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:0015234 ! thiamine transmembrane transporter activity
is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity
is_a: GO:0019829 ! cation-transporting ATPase activity
is_a: GO:0090422 ! thiamine pyrophosphate transporter activity

[Term]
id: GO:0015620
name: ferric-enterobactin transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of ferric-enterobactin from one side of a membrane to the other." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015343 ! siderophore transmembrane transporter activity
relationship: part_of GO:0015685 ! ferric-enterobactin transport

[Term]
id: GO:0015621
name: ferric triacetylfusarinine C transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of ferric triacetylfusarinine C from one side of a membrane to the other." [GOC:ai]
is_a: GO:0015091 ! ferric iron transmembrane transporter activity

[Term]
id: GO:0015622
name: ferric-hydroxamate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of ferric-hydroxamate from one side of a membrane to the other." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015343 ! siderophore transmembrane transporter activity
relationship: part_of GO:0015687 ! ferric-hydroxamate transport

[Term]
id: GO:0015623
name: iron-chelate-transporting ATPase activity
namespace: molecular_function
alt_id: GO:0015409
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + iron chelate(out) = ADP + phosphate + iron chelate(in). Fe-enterobactin, Fe-dicitrate, Fe-hydroxamate and other siderophores are imported." [EC:3.6.3.34]
subset: gosubset_prok
synonym: "ATP phosphohydrolase (iron-chelate-importing)" EXACT [EC:3.6.3.34]
synonym: "ferric/ferric-dicitrate porter" BROAD []
synonym: "iron-chelate ABC transporter" NARROW []
xref: EC:3.6.3.34
xref: MetaCyc:3.6.3.34-RXN
is_a: GO:0015603 ! iron chelate transmembrane transporter activity
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances

[Term]
id: GO:0015624
name: ferric-enterobactin-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + ferric-enterobactin(out) = ADP + phosphate + ferric-enterobactin(in)." [EC:3.6.3.34, TC:3.A.1.-.-]
synonym: "ferric-enterobactin ABC transporter" NARROW []
synonym: "ferric-enterobactin porter activity" BROAD []
xref: MetaCyc:ABC-10-RXN
is_a: GO:0015620 ! ferric-enterobactin transmembrane transporter activity
is_a: GO:0015623 ! iron-chelate-transporting ATPase activity
is_a: GO:0019829 ! cation-transporting ATPase activity

[Term]
id: GO:0015625
name: ferric-hydroxamate-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + ferric-hydroxamate(out) = ADP + phosphate + ferric-hydroxamate(in)." [EC:3.6.3.34, TC:3.A.1.-.-]
synonym: "ferric-hydroxamate ABC transporter" NARROW []
synonym: "ferric-hydroxamate porter activity" BROAD []
xref: MetaCyc:ABC-11-RXN
is_a: GO:0015622 ! ferric-hydroxamate transmembrane transporter activity
is_a: GO:0015623 ! iron-chelate-transporting ATPase activity
is_a: GO:0019829 ! cation-transporting ATPase activity

[Term]
id: GO:0015626
name: L-diaminopimelate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of L-diaminopimelate from one side of a membrane to the other. L-diaminopimelate is the L-enantiomer anion of 2,6-diaminoheptanedioic acid." [GOC:go_curators, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
synonym: "cystine/diaminopimelate porter activity" NARROW []
synonym: "L-diaminopimelate transporter activity" BROAD []
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity
relationship: part_of GO:0015830 ! diaminopimelate transport

[Term]
id: GO:0015627
name: type II protein secretion system complex
namespace: cellular_component
def: "A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex." [PMID:16448494]
comment: Note that the type II protein secretion system complex does not include components of the Sec or Tat pathways. For components of these pathways, consider annotating to 'cell envelope Sec complex ; GO:0031522' or 'TAT protein translocation system complex ; GO:0033281'.
subset: gosubset_prok
synonym: "general secretion pathway-associated complex" RELATED []
synonym: "main terminal branch" EXACT []
synonym: "MTB" EXACT []
synonym: "Sec-dependent secretion system-associated complex" RELATED []
synonym: "T2SS-associated complexes" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0015628
name: protein secretion by the type II secretion system
namespace: biological_process
def: "The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways." [GOC:pamgo_curators]
comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular component term 'type II protein secretion system complex ; GO:0015627'. This process refers specifically to secretion across the outer membrane. For components of the Sec and Tat pathways, consider annotating to 'protein transport by the Sec complex ; GO:0043952' and 'protein transport by the Tat complex ; GO:0043953'. Note that this term is used for annotation of proteins that compose the secretion complex but not the proteins being secreted.
subset: gosubset_prok
synonym: "protein secretion by the general secretion pathway" RELATED []
synonym: "protein secretion by the general secretory pathway" RELATED []
synonym: "protein secretion by the T2S" EXACT []
synonym: "protein secretion by the T2SS" EXACT []
synonym: "protein secretion by the type II protein secretion system" EXACT []
synonym: "type II protein secretion system" EXACT []
is_a: GO:0009306 ! protein secretion
is_a: GO:0098776 ! protein transport across the cell outer membrane

[Term]
id: GO:0015629
name: actin cytoskeleton
namespace: cellular_component
def: "The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]
subset: goslim_aspergillus
is_a: GO:0005856 ! cytoskeleton

[Term]
id: GO:0015630
name: microtubule cytoskeleton
namespace: cellular_component
def: "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172]
subset: goslim_aspergillus
is_a: GO:0005856 ! cytoskeleton

[Term]
id: GO:0015631
name: tubulin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with monomeric or multimeric forms of tubulin, including microtubules." [GOC:clt]
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0015633
name: zinc transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Zn2+(out) = ADP + phosphate + Zn2+(in)." [TC:3.A.1.-.-]
synonym: "zinc porter activity" RELATED []
xref: RHEA:29798
is_a: GO:0005385 ! zinc ion transmembrane transporter activity

[Term]
id: GO:0015634
name: lipopolysaccharide exporter activity
namespace: molecular_function
def: "Catalysis of the transfer of lipopolysaccharide from the inside of the cell to the outside of the cell across a membrane. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide." [GOC:mtg_transport, ISBN:0815340729]
synonym: "LPS exporter activity" EXACT []
is_a: GO:0015221 ! lipopolysaccharide transmembrane transporter activity
is_a: GO:0015562 ! efflux transmembrane transporter activity

[Term]
id: GO:0015635
name: short-chain fatty acid transporter activity
namespace: molecular_function
def: "Enables the directed movement of short-chain fatty acids into, out of or within a cell, or between cells. Short-chain fatty acids are fatty acids with a chain length of less than C6." [CHEBI:26666, ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0015245 ! fatty acid transporter activity
relationship: part_of GO:0015912 ! short-chain fatty acid transport

[Term]
id: GO:0015636
name: short-chain fatty acid uptake transporter activity
namespace: molecular_function
def: "Enables the directed movement of short-chain fatty acids into a cell or organelle. Short-chain fatty acids are fatty acids with a chain length of less than C6." [CHEBI:26666, GOC:mah]
is_a: GO:0015635 ! short-chain fatty acid transporter activity
relationship: part_of GO:0015913 ! short-chain fatty acid import

[Term]
id: GO:0015638
name: microcin uptake transporter activity
namespace: molecular_function
def: "Enables the transfer of a microcin from the outside of a cell to the inside of the cell across a membrane." [GOC:mah]
subset: gosubset_prok
synonym: "microcin uptake permease activity" EXACT []
is_a: GO:0015238 ! drug transmembrane transporter activity
is_a: GO:1904680 ! peptide transmembrane transporter activity
relationship: part_of GO:0042884 ! microcin transport

[Term]
id: GO:0015639
name: ferrous iron uptake transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Fe2+(out) + energy = Fe2+(in)." [TC:9.A.8.1.1]
subset: gosubset_prok
is_a: GO:0015093 ! ferrous iron transmembrane transporter activity

[Term]
id: GO:0015640
name: peptidoglycan peptide transporter activity
namespace: molecular_function
def: "Enables the directed movement of peptidoglycan peptides into, out of or within a cell, or between cells. Peptidoglycan peptides are the oligopeptides found in peptidoglycan networks which cross-link the polysaccharide chains." [ISBN:0198506732]
subset: gosubset_prok
synonym: "murein peptide transporter activity" EXACT []
synonym: "muropeptide transporter activity" EXACT []
is_a: GO:0015197 ! peptide transporter activity
is_a: GO:0015647 ! peptidoglycan transporter activity
relationship: part_of GO:0015834 ! peptidoglycan-associated peptide transport

[Term]
id: GO:0015641
name: obsolete lipoprotein toxin
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "lipoprotein toxin" EXACT []
is_obsolete: true
consider: GO:0009405
consider: GO:0050827

[Term]
id: GO:0015642
name: obsolete bacteriolytic toxin activity
namespace: molecular_function
def: "OBSOLETE. Acts as to cause lysis of bacterial cells." [GOC:jl]
comment: This term was made obsolete because it represents a class of gene products and not a molecular function.
synonym: "bacteriolytic toxin activity" EXACT []
is_obsolete: true
consider: GO:0019835

[Term]
id: GO:0015643
name: toxic substance binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a toxic substance, a poisonous substance that causes damage to biological systems." [GOC:bf, GOC:curators, GOC:jl, GOC:pr]
synonym: "antitoxin activity" RELATED []
synonym: "lipoprotein antitoxin" RELATED []
is_a: GO:0005488 ! binding

[Term]
id: GO:0015644
name: obsolete lipoprotein antitoxin
namespace: molecular_function
def: "OBSOLETE. Binds to a lipoprotein toxin, which is usually derived from a microorganism, thereby neutralizing it." [GOC:jl]
comment: This term was made obsolete because it does not represent a function distinct from its parent term.
synonym: "lipoprotein antitoxin" EXACT []
is_obsolete: true
replaced_by: GO:0015643

[Term]
id: GO:0015645
name: fatty acid ligase activity
namespace: molecular_function
def: "Catalysis of the ligation of a fatty acid to an acceptor, coupled to the hydrolysis of ATP." [EC:6.2.1.20, EC:6.2.1.3, GOC:cjk, GOC:mah]
subset: gosubset_prok
synonym: "acid:CoA ligase (AMP-forming) activity" EXACT [EC:6.2.1.3]
synonym: "acyl coenzyme A synthetase activity" EXACT [EC:6.2.1.3]
synonym: "acyl-coenzyme A ligase activity" EXACT [EC:6.2.1.3]
synonym: "fatty acid CoA ligase activity" EXACT [EC:6.2.1.3]
synonym: "fatty acyl-coenzyme A synthetase activity" EXACT [EC:6.2.1.3]
synonym: "fatty-acid ligase activity" EXACT []
xref: EC:6.2.1.-
is_a: GO:0016877 ! ligase activity, forming carbon-sulfur bonds

[Term]
id: GO:0015647
name: peptidoglycan transporter activity
namespace: molecular_function
def: "Enables the directed movement of peptidoglycans, a class of glycoconjugates found in bacterial cell walls, into, out of or within a cell, or between cells." [GOC:ai]
subset: gosubset_prok
synonym: "murein transporter activity" EXACT []
is_a: GO:0022892 ! substrate-specific transporter activity
is_a: GO:1901505 ! carbohydrate derivative transporter activity
relationship: part_of GO:0015835 ! peptidoglycan transport

[Term]
id: GO:0015648
name: lipid-linked peptidoglycan transporter activity
namespace: molecular_function
def: "Enables the directed movement of lipid-linked peptidoglycans into, out of or within a cell, or between cells." [GOC:mah]
synonym: "lipid-linked murein transporter activity" EXACT []
is_a: GO:0015647 ! peptidoglycan transporter activity
relationship: part_of GO:0015836 ! lipid-linked peptidoglycan transport

[Term]
id: GO:0015649
name: 2-keto-3-deoxygluconate:proton symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 2-keto-3-deoxygluconate(out) + H+(out) = 2-keto-3-deoxygluconate(in) + H+(in)." [TC:2.A.10.1.1]
subset: gosubset_prok
synonym: "2-keto-3-deoxygluconate:hydrogen symporter activity" EXACT []
is_a: GO:0005402 ! cation:sugar symporter activity
is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity
is_a: GO:0015128 ! gluconate transmembrane transporter activity
is_a: GO:0015296 ! anion:cation symporter activity
relationship: part_of GO:0046411 ! 2-keto-3-deoxygluconate transport

[Term]
id: GO:0015650
name: lactate:proton symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lactate (out) + H+ (out) = lactate (in) + H+ (in)." [TC:2.A.14.1.1]
synonym: "lactate permease" BROAD []
synonym: "lactate:hydrogen porter activity" EXACT []
synonym: "lactate:hydrogen symporter activity" EXACT []
synonym: "lactate:proton porter activity" EXACT []
is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity
is_a: GO:0015129 ! lactate transmembrane transporter activity
is_a: GO:0015296 ! anion:cation symporter activity

[Term]
id: GO:0015651
name: quaternary ammonium group transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015202
def: "Enables the transfer of quaternary ammonium groups from one side of a membrane to the other. Quaternary ammonium groups are any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups." [ISBN:0198506732]
subset: gosubset_prok
synonym: "quaternary amine transmembrane transporter activity" EXACT []
synonym: "quaternary ammonium compound transporter activity" EXACT []
is_a: GO:0015101 ! organic cation transmembrane transporter activity
relationship: part_of GO:0015697 ! quaternary ammonium group transport

[Term]
id: GO:0015652
name: quaternary ammonium group:proton symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: quaternary ammonium group(out) + H+(out) = quaternary ammonium group(in) + H+(in)." [GOC:ai]
subset: gosubset_prok
synonym: "quaternary ammonium group:hydrogen symporter activity" EXACT []
is_a: GO:0015295 ! solute:proton symporter activity
is_a: GO:0015651 ! quaternary ammonium group transmembrane transporter activity

[Term]
id: GO:0015653
name: glycine betaine:proton symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine betaine(out) + H+(out) = glycine betaine(in) + H+(in)." [TC:2.A.15.1.1]
subset: gosubset_prok
synonym: "glycine betaine:hydrogen symporter activity" EXACT []
is_a: GO:0015199 ! amino-acid betaine transmembrane transporter activity
is_a: GO:0015652 ! quaternary ammonium group:proton symporter activity
relationship: part_of GO:0031460 ! glycine betaine transport

[Term]
id: GO:0015654
name: tellurite uptake transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of tellurite from the outside of a cell to the inside across a membrane: tellurite(out) + H+(out) = tellurite(in) + H+(in)." [GOC:mtg_transport, ISBN:0815340729, TC:2.A.16.1.1]
synonym: "tellurite-resistance uptake permease activity" EXACT []
synonym: "tellurite-resistance uptake transmembrane transporter activity" EXACT []
is_a: GO:0015118 ! tellurite transmembrane transporter activity
is_a: GO:0015563 ! uptake transmembrane transporter activity

[Term]
id: GO:0015655
name: alanine:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alanine(out) + Na+(out) = alanine(in) + Na+(in)." [GOC:ai]
subset: gosubset_prok
is_a: GO:0005283 ! sodium:amino acid symporter activity
is_a: GO:0005294 ! neutral L-amino acid secondary active transmembrane transporter activity
is_a: GO:0015296 ! anion:cation symporter activity
is_a: GO:0022858 ! alanine transmembrane transporter activity

[Term]
id: GO:0015657
name: branched-chain amino acid:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: branched-chain amino acid(out) + cation(out) = branched-chain amino acid(in) + cation(in)." [TC:2.A.26.1.1]
is_a: GO:0005283 ! sodium:amino acid symporter activity
is_a: GO:0015296 ! anion:cation symporter activity
is_a: GO:0015658 ! branched-chain amino acid transmembrane transporter activity

[Term]
id: GO:0015658
name: branched-chain amino acid transmembrane transporter activity
namespace: molecular_function
alt_id: GO:1901240
def: "Enables the transfer of branched-chain amino acids from one side of a membrane to the other. Branched-chain amino acids are amino acids with a branched carbon skeleton without rings." [CHEBI:22918, GOC:ai, GOC:bf, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "branched-chain aliphatic amino acid transmembrane transporter activity" EXACT [GOC:bf]
synonym: "branched-chain aliphatic amino acid transporter activity" EXACT []
synonym: "leucine/valine/isoleucine permease activity" RELATED []
synonym: "valine/tyrosine/tryptophan permease activity" RELATED []
is_a: GO:0015171 ! amino acid transmembrane transporter activity
relationship: part_of GO:0015803 ! branched-chain amino acid transport

[Term]
id: GO:0015659
name: formate uptake transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of formate from the outside of a cell to the inside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729]
synonym: "formate uptake permease activity" EXACT []
is_a: GO:0015499 ! formate transmembrane transporter activity
is_a: GO:0015563 ! uptake transmembrane transporter activity

[Term]
id: GO:0015660
name: formate efflux transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015509
def: "Catalysis of the transfer of formate from the inside of the cell to the outside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729]
synonym: "formate efflux permease activity" EXACT []
is_a: GO:0015499 ! formate transmembrane transporter activity
is_a: GO:0015562 ! efflux transmembrane transporter activity

[Term]
id: GO:0015661
name: L-lysine efflux transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of L-lysine from the inside of the cell to the outside of the cell across a membrane." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "L-lysine exporter activity" EXACT []
synonym: "L-lysine, 2,6-diaminohexanoic acid efflux transmembrane transporter activity" EXACT []
is_a: GO:0015189 ! L-lysine transmembrane transporter activity
is_a: GO:0034639 ! L-amino acid efflux transmembrane transporter activity

[Term]
id: GO:0015662
name: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate." [PMID:10322420, PMID:10600683]
subset: gosubset_prok
synonym: "P-type ATPase activity" EXACT []
synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" NARROW []
xref: Reactome:REACT_118096 "ABCC4 accumulation of dense granule contents, Danio rerio"
xref: Reactome:REACT_118097 "ABCC4 accumulation of dense granule contents, Caenorhabditis elegans"
xref: Reactome:REACT_118107 "ABCC4 accumulation of dense granule contents, Drosophila melanogaster"
xref: Reactome:REACT_118117 "ABCC4 accumulation of dense granule contents, Xenopus tropicalis"
xref: Reactome:REACT_118152 "ABCC4 accumulation of dense granule contents, Bos taurus"
xref: Reactome:REACT_118251 "ABCC4 accumulation of dense granule contents, Sus scrofa"
xref: Reactome:REACT_118297 "ABCC4 accumulation of dense granule contents, Taeniopygia guttata"
xref: Reactome:REACT_118311 "ABCC4 accumulation of dense granule contents, Gallus gallus"
xref: Reactome:REACT_118326 "ABCC4 accumulation of dense granule contents, Escherichia coli"
xref: Reactome:REACT_118375 "ABCC4 accumulation of dense granule contents, Canis familiaris"
xref: Reactome:REACT_118386 "ABCC4 accumulation of dense granule contents, Mus musculus"
xref: Reactome:REACT_23865 "ABCC4 accumulation of dense granule contents, Homo sapiens"
is_a: GO:0042625 ! ATPase coupled ion transmembrane transporter activity

[Term]
id: GO:0015663
name: nicotinamide mononucleotide transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015664
def: "Enables the directed movement of nicotinamide mononucleotide into, out of or within a cell, or between cells. Nicotinamide mononucleotide is a ribonucleotide in which the nitrogenous base, nicotinamide, is in beta-n-glycosidic linkage with the c-1 position of d-ribose. It is a constituent of NAD and NADP." [CHEBI:50383, GOC:curators, ISBN:0721662544]
subset: gosubset_prok
synonym: "nicotinamide mononucleotide permease activity" RELATED []
synonym: "nicotinamide ribonucleotide transmembrane transporter activity" EXACT []
is_a: GO:0015215 ! nucleotide transmembrane transporter activity
is_a: GO:0051184 ! cofactor transporter activity
is_a: GO:1901505 ! carbohydrate derivative transporter activity
relationship: part_of GO:0035353 ! nicotinamide mononucleotide transmembrane transport

[Term]
id: GO:0015665
name: alcohol transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of an alcohol from one side of the membrane to the other. An alcohol is any carbon compound that contains a hydroxyl group." [ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity
is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity

[Term]
id: GO:0015666
name: restriction endodeoxyribonuclease activity
namespace: molecular_function
def: "Catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks." [GOC:mlg]
subset: gosubset_prok
synonym: "restriction endonuclease activity" EXACT []
synonym: "restriction enzyme activity" EXACT []
is_a: GO:0004520 ! endodeoxyribonuclease activity

[Term]
id: GO:0015667
name: site-specific DNA-methyltransferase (cytosine-N4-specific) activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + DNA cytosine = S-adenosyl-L-homocysteine + DNA N4-methylcytosine." [EC:2.1.1.113]
subset: gosubset_prok
synonym: "DNA[cytosine-N4]methyltransferase activity" EXACT [EC:2.1.1.113]
synonym: "m4C-forming MTase activity" EXACT [EC:2.1.1.113]
synonym: "modification methylase activity" RELATED [EC:2.1.1.113]
synonym: "N(4)-cytosine-specific DNA methylase activity" EXACT [EC:2.1.1.113]
synonym: "N4-cytosine-specific DNA methylase activity" EXACT [EC:2.1.1.113]
synonym: "restriction-modification system activity" RELATED [EC:2.1.1.113]
synonym: "S-adenosyl-L-methionine:DNA-cytosine 4-N-methyltransferase activity" EXACT [EC:2.1.1.113]
synonym: "S-adenosyl-L-methionine:DNA-cytosine N4-methyltransferase activity" EXACT [EC:2.1.1.113]
xref: EC:2.1.1.113
xref: MetaCyc:2.1.1.113-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
is_a: GO:0009008 ! DNA-methyltransferase activity
relationship: part_of GO:0090124 ! N-4 methylation of cytosine

[Term]
id: GO:0015668
name: Type III site-specific deoxyribonuclease activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of DNA to give double-stranded fragments with terminal 5'-phosphates. ATP hydrolysis is required. Cleavage is dependent on the presence of two copies of a specific recognition sequence in an inverse orientation in the DNA. Cleavage occurs at a specific distance from one of the recognition sites." [EC:3.1.21.5, PMID:12654995]
subset: gosubset_prok
synonym: "Type III restriction enzyme activity" EXACT []
xref: EC:3.1.21.5
xref: MetaCyc:3.1.21.5-RXN
is_a: GO:0015666 ! restriction endodeoxyribonuclease activity
is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0015669
name: gas transport
namespace: biological_process
def: "The directed movement of substances that are gaseous in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0044765 ! single-organism transport

[Term]
id: GO:0015670
name: carbon dioxide transport
namespace: biological_process
def: "The directed movement of carbon dioxide (CO2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0015669 ! gas transport
is_a: GO:0019755 ! one-carbon compound transport

[Term]
id: GO:0015671
name: oxygen transport
namespace: biological_process
def: "The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015669 ! gas transport

[Term]
id: GO:0015672
name: monovalent inorganic cation transport
namespace: biological_process
def: "The directed movement of inorganic cations with a valency of one into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006812 ! cation transport

[Term]
id: GO:0015673
name: silver ion transport
namespace: biological_process
def: "The directed movement of silver (Ag) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "silver transport" EXACT []
is_a: GO:0000041 ! transition metal ion transport

[Term]
id: GO:0015675
name: nickel cation transport
namespace: biological_process
def: "The directed movement of nickel (Ni) cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
is_a: GO:0000041 ! transition metal ion transport

[Term]
id: GO:0015676
name: vanadium ion transport
namespace: biological_process
def: "The directed movement of vanadium (V) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0000041 ! transition metal ion transport

[Term]
id: GO:0015677
name: copper ion import
namespace: biological_process
def: "The directed movement of copper ions into a cell or organelle." [GOC:ai]
synonym: "copper ion uptake" EXACT [GOC:dph, GOC:tb]
is_a: GO:0006825 ! copper ion transport

[Term]
id: GO:0015678
name: high-affinity copper ion transport
namespace: biological_process
def: "The directed, high-affinity movement of copper (Cu) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mah]
synonym: "high affinity copper ion transport" EXACT []
synonym: "high affinity copper transport" EXACT []
is_a: GO:0035434 ! copper ion transmembrane transport

[Term]
id: GO:0015679
name: plasma membrane copper ion transport
namespace: biological_process
def: "The directed movement of copper ions across the plasma membrane." [GOC:ai]
synonym: "plasma membrane copper transport" EXACT []
is_a: GO:0035434 ! copper ion transmembrane transport

[Term]
id: GO:0015680
name: intracellular copper ion transport
namespace: biological_process
def: "The directed movement of copper (Cu) ions within a cell." [GOC:ai]
synonym: "intracellular copper delivery" EXACT []
is_a: GO:0006825 ! copper ion transport
is_a: GO:1902582 ! single-organism intracellular transport
intersection_of: GO:0006825 ! copper ion transport
intersection_of: occurs_in GO:0005622 ! intracellular
relationship: occurs_in GO:0005622 ! intracellular

[Term]
id: GO:0015682
name: ferric iron transport
namespace: biological_process
def: "The directed movement of ferric iron (Fe(III) or Fe3+) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "ferric ion transport" EXACT []
is_a: GO:0006826 ! iron ion transport
is_a: GO:0072512 ! trivalent inorganic cation transport

[Term]
id: GO:0015683
name: high-affinity ferric iron transport
namespace: biological_process
def: "The directed, high-affinity movement of ferric (Fe(III) or Fe3+) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mah]
synonym: "high affinity ferric iron transport" EXACT []
is_a: GO:0006827 ! high-affinity iron ion transmembrane transport
is_a: GO:0015682 ! ferric iron transport

[Term]
id: GO:0015684
name: ferrous iron transport
namespace: biological_process
def: "The directed movement of ferrous iron (Fe(II) or Fe2+) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "ferrous ion transport" EXACT []
is_a: GO:0006826 ! iron ion transport
is_a: GO:0070838 ! divalent metal ion transport

[Term]
id: GO:0015685
name: ferric-enterobactin transport
namespace: biological_process
def: "The directed movement of ferric-enterobactin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015682 ! ferric iron transport
is_a: GO:0015688 ! iron chelate transport
is_a: GO:0015711 ! organic anion transport

[Term]
id: GO:0015686
name: ferric triacetylfusarinine C transport
namespace: biological_process
def: "The directed movement of ferric triacetylfusarinine C into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0015891 ! siderophore transport
is_a: GO:0071702 ! organic substance transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0015687
name: ferric-hydroxamate transport
namespace: biological_process
def: "The directed movement of ferric-hydroxamate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015682 ! ferric iron transport
is_a: GO:0015891 ! siderophore transport
is_a: GO:0042886 ! amide transport
is_a: GO:0071702 ! organic substance transport

[Term]
id: GO:0015688
name: iron chelate transport
namespace: biological_process
def: "The directed movement of iron chelates into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An iron chelate is a heterocyclic compound having a metal ion attached by coordinate bonds to at least two nonmetal ions." [GOC:ai]
subset: gosubset_prok
is_a: GO:1901678 ! iron coordination entity transport

[Term]
id: GO:0015689
name: molybdate ion transport
namespace: biological_process
def: "The directed movement of molybdate (MoO4 2-) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Molybdate is the bivalent anion derived from molybdic acid." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015698 ! inorganic anion transport

[Term]
id: GO:0015690
name: aluminum cation transport
namespace: biological_process
def: "The directed movement of aluminum (Al) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "aluminium ion transport" EXACT []
synonym: "aluminium transport" EXACT []
synonym: "aluminum ion transport" RELATED []
synonym: "aluminum transport" EXACT []
is_a: GO:0030001 ! metal ion transport
is_a: GO:0072512 ! trivalent inorganic cation transport

[Term]
id: GO:0015691
name: cadmium ion transport
namespace: biological_process
def: "The directed movement of cadmium (Cd) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "cadmium transport" EXACT []
is_a: GO:0000041 ! transition metal ion transport
is_a: GO:0070838 ! divalent metal ion transport

[Term]
id: GO:0015692
name: lead ion transport
namespace: biological_process
def: "The directed movement of lead (Pb) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
is_a: GO:0030001 ! metal ion transport

[Term]
id: GO:0015693
name: magnesium ion transport
namespace: biological_process
def: "The directed movement of magnesium (Mg) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "magnesium transport" RELATED []
is_a: GO:0070838 ! divalent metal ion transport

[Term]
id: GO:0015694
name: mercury ion transport
namespace: biological_process
def: "The directed movement of mercury (Hg) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "mercuric ion transport" NARROW []
synonym: "mercury transport" EXACT []
is_a: GO:0000041 ! transition metal ion transport
is_a: GO:0072511 ! divalent inorganic cation transport
relationship: part_of GO:0050787 ! detoxification of mercury ion

[Term]
id: GO:0015695
name: organic cation transport
namespace: biological_process
def: "The directed movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006812 ! cation transport
is_a: GO:0071702 ! organic substance transport

[Term]
id: GO:0015696
name: ammonium transport
namespace: biological_process
def: "The directed movement of ammonium into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals." [ISBN:0198506732]
subset: gosubset_prok
synonym: "ammonia transport" RELATED []
is_a: GO:0015672 ! monovalent inorganic cation transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0015697
name: quaternary ammonium group transport
namespace: biological_process
alt_id: GO:0015845
def: "The directed movement into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore of quaternary ammonium compounds, any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups." [GOC:ai, ISBN:0198506732]
subset: gosubset_prok
synonym: "quaternary amine transport" EXACT []
synonym: "quaternary ammonium compound transport" EXACT []
is_a: GO:0044765 ! single-organism transport
is_a: GO:0071702 ! organic substance transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0015698
name: inorganic anion transport
namespace: biological_process
def: "The directed movement of inorganic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage." [GOC:krc]
subset: gosubset_prok
is_a: GO:0006820 ! anion transport

[Term]
id: GO:0015699
name: antimonite transport
namespace: biological_process
def: "The directed movement of antimonite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
subset: gosubset_prok
is_a: GO:0015698 ! inorganic anion transport

[Term]
id: GO:0015700
name: arsenite transport
namespace: biological_process
def: "The directed movement of arsenite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
subset: gosubset_prok
is_a: GO:0015698 ! inorganic anion transport

[Term]
id: GO:0015701
name: bicarbonate transport
namespace: biological_process
def: "The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
xref: Reactome:REACT_100525 "Bicarbonate transporters, Danio rerio"
xref: Reactome:REACT_100774 "Bicarbonate transporters, Canis familiaris"
xref: Reactome:REACT_102789 "Bicarbonate transporters, Sus scrofa"
xref: Reactome:REACT_103081 "Bicarbonate transporters, Drosophila melanogaster"
xref: Reactome:REACT_114123 "Bicarbonate transporters, Dictyostelium discoideum"
xref: Reactome:REACT_19298 "Bicarbonate transporters, Homo sapiens"
xref: Reactome:REACT_31940 "Bicarbonate transporters, Mus musculus"
xref: Reactome:REACT_58996 "Bicarbonate transporters, Gallus gallus"
xref: Reactome:REACT_84164 "Bicarbonate transporters, Bos taurus"
xref: Reactome:REACT_92211 "Bicarbonate transporters, Taeniopygia guttata"
xref: Reactome:REACT_95367 "Bicarbonate transporters, Rattus norvegicus"
xref: Reactome:REACT_95717 "Bicarbonate transporters, Xenopus tropicalis"
xref: Reactome:REACT_96648 "Bicarbonate transporters, Caenorhabditis elegans"
is_a: GO:0015711 ! organic anion transport

[Term]
id: GO:0015702
name: chlorate transport
namespace: biological_process
def: "The directed movement of chlorate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
is_a: GO:0015698 ! inorganic anion transport

[Term]
id: GO:0015703
name: chromate transport
namespace: biological_process
def: "The directed movement of chromate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
subset: gosubset_prok
is_a: GO:0015698 ! inorganic anion transport

[Term]
id: GO:0015704
name: cyanate transport
namespace: biological_process
def: "The directed movement of cyanate, NCO-, the anion of cyanic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
subset: gosubset_prok
is_a: GO:0006820 ! anion transport
is_a: GO:0019755 ! one-carbon compound transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0015705
name: iodide transport
namespace: biological_process
def: "The directed movement of iodide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
is_a: GO:0015698 ! inorganic anion transport

[Term]
id: GO:0015706
name: nitrate transport
namespace: biological_process
alt_id: GO:0006872
def: "The directed movement of nitrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
subset: gosubset_prok
is_a: GO:0015698 ! inorganic anion transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0015707
name: nitrite transport
namespace: biological_process
def: "The directed movement of nitrite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
subset: gosubset_prok
is_a: GO:0015698 ! inorganic anion transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0015708
name: silicate transport
namespace: biological_process
alt_id: GO:0051207
def: "The directed movement of silicates into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Silicates are the salts of silicic acids, and are usually composed of silicon and oxygen (Si[x]O[y]), one or more metals, and possibly hydrogen. Types of silicate include unisilicates, metasilicates and hydrous silicates." [GOC:ai, GOC:krc, http://www.onelook.com]
synonym: "silicic acid transport" EXACT []
is_a: GO:0015698 ! inorganic anion transport

[Term]
id: GO:0015709
name: thiosulfate transport
namespace: biological_process
def: "The directed movement of thiosulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
subset: gosubset_prok
synonym: "thiosulphate transport" EXACT []
is_a: GO:0015698 ! inorganic anion transport
is_a: GO:0072348 ! sulfur compound transport

[Term]
id: GO:0015710
name: tellurite transport
namespace: biological_process
def: "The directed movement of tellurite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
subset: gosubset_prok
is_a: GO:0015698 ! inorganic anion transport

[Term]
id: GO:0015711
name: organic anion transport
namespace: biological_process
def: "The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage." [GOC:ai, GOC:krc]
subset: gosubset_prok
is_a: GO:0006820 ! anion transport
is_a: GO:0071702 ! organic substance transport

[Term]
id: GO:0015712
name: hexose phosphate transport
namespace: biological_process
def: "The directed movement of hexose phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
subset: gosubset_prok
is_a: GO:0015748 ! organophosphate ester transport
is_a: GO:1901264 ! carbohydrate derivative transport

[Term]
id: GO:0015713
name: phosphoglycerate transport
namespace: biological_process
def: "The directed movement of phosphoglycerate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
subset: gosubset_prok
is_a: GO:0015748 ! organophosphate ester transport
is_a: GO:0042873 ! aldonate transport
is_a: GO:1901264 ! carbohydrate derivative transport

[Term]
id: GO:0015714
name: phosphoenolpyruvate transport
namespace: biological_process
def: "The directed movement of phosphoenolpyruvate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0015748 ! organophosphate ester transport

[Term]
id: GO:0015715
name: nucleotide-sulfate transport
namespace: biological_process
def: "The directed movement of nucleotide sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "nucleotide-sulphate transport" EXACT []
is_a: GO:0006862 ! nucleotide transport
is_a: GO:0015711 ! organic anion transport
is_a: GO:0072348 ! sulfur compound transport

[Term]
id: GO:0015716
name: organic phosphonate transport
namespace: biological_process
def: "The directed movement of phosphonates into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2)." [GOC:krc]
subset: gosubset_prok
is_a: GO:0044765 ! single-organism transport
is_a: GO:0071702 ! organic substance transport

[Term]
id: GO:0015717
name: triose phosphate transport
namespace: biological_process
def: "The directed movement of triose phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
synonym: "aldotriose phosphate transport" EXACT []
is_a: GO:0015748 ! organophosphate ester transport
is_a: GO:1901264 ! carbohydrate derivative transport

[Term]
id: GO:0015718
name: monocarboxylic acid transport
namespace: biological_process
def: "The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
subset: gosubset_prok
is_a: GO:0046942 ! carboxylic acid transport

[Term]
id: GO:0015719
name: allantoate transport
namespace: biological_process
def: "The directed movement of allantoate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
synonym: "allantoin/allantoate transport" BROAD []
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0042886 ! amide transport

[Term]
id: GO:0015720
name: allantoin transport
namespace: biological_process
def: "The directed movement of allantoin, (2,5-dioxo-4-imidazolidinyl)urea, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "allantoin transmembrane transport" EXACT [GOC:mah]
synonym: "allantoin/allantoate transport" BROAD []
is_a: GO:0042886 ! amide transport
is_a: GO:0071702 ! organic substance transport

[Term]
id: GO:0015721
name: bile acid and bile salt transport
namespace: biological_process
def: "The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:krc, PMID:12663868, PMID:14699511]
synonym: "bile acid transport" NARROW []
synonym: "bile salt transport" NARROW []
xref: Reactome:REACT_103326 "Recycling of bile acids and salts, Sus scrofa"
xref: Reactome:REACT_108751 "Recycling of bile acids and salts, Bos taurus"
xref: Reactome:REACT_109681 "Recycling of bile acids and salts, Mycobacterium tuberculosis"
xref: Reactome:REACT_11042 "Recycling of bile acids and salts, Homo sapiens"
xref: Reactome:REACT_112634 "Recycling of bile acids and salts, Dictyostelium discoideum"
xref: Reactome:REACT_113431 "Recycling of bile acids and salts, Plasmodium falciparum"
xref: Reactome:REACT_113858 "Recycling of bile acids and salts, Saccharomyces cerevisiae"
xref: Reactome:REACT_114004 "Recycling of bile acids and salts, Arabidopsis thaliana"
xref: Reactome:REACT_114070 "Recycling of bile acids and salts, Oryza sativa"
xref: Reactome:REACT_114193 "Recycling of bile acids and salts, Schizosaccharomyces pombe"
xref: Reactome:REACT_41714 "Recycling of bile acids and salts, Rattus norvegicus"
xref: Reactome:REACT_48622 "Recycling of bile acids and salts, Gallus gallus"
xref: Reactome:REACT_79710 "Recycling of bile acids and salts, Xenopus tropicalis"
xref: Reactome:REACT_82323 "Recycling of bile acids and salts, Canis familiaris"
xref: Reactome:REACT_86403 "Recycling of bile acids and salts, Taeniopygia guttata"
xref: Reactome:REACT_88701 "Recycling of bile acids and salts, Drosophila melanogaster"
xref: Reactome:REACT_96826 "Recycling of bile acids and salts, Mus musculus"
xref: Reactome:REACT_97352 "Recycling of bile acids and salts, Danio rerio"
is_a: GO:0006869 ! lipid transport
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0015850 ! organic hydroxy compound transport

[Term]
id: GO:0015722
name: canalicular bile acid transport
namespace: biological_process
def: "Catalysis of the transfer of bile acid from one side of a hepatocyte plasma membrane into a bile canaliculus. Bile canaliculi are the thin tubes formed by hepatocyte membranes. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine." [GOC:dph]
is_a: GO:0032782 ! bile acid secretion

[Term]
id: GO:0015723
name: bilirubin transport
namespace: biological_process
def: "The directed movement of bilirubin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
is_a: GO:0006835 ! dicarboxylic acid transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0015724
name: formate transport
namespace: biological_process
def: "The directed movement of formate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
subset: gosubset_prok
is_a: GO:0015718 ! monocarboxylic acid transport

[Term]
id: GO:0015725
name: gluconate transport
namespace: biological_process
def: "The directed movement of gluconate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Gluconate is the aldonic acid derived from glucose." [GOC:ai, ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0042873 ! aldonate transport

[Term]
id: GO:0015726
name: L-idonate transport
namespace: biological_process
def: "The directed movement of L-idonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. L-idonate is an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose." [GOC:krc]
subset: gosubset_prok
is_a: GO:0042873 ! aldonate transport

[Term]
id: GO:0015727
name: lactate transport
namespace: biological_process
def: "The directed movement of lactate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices." [GOC:ai, ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0015850 ! organic hydroxy compound transport

[Term]
id: GO:0015728
name: mevalonate transport
namespace: biological_process
def: "The directed movement of mevalonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0015850 ! organic hydroxy compound transport

[Term]
id: GO:0015729
name: oxaloacetate transport
namespace: biological_process
def: "The directed movement of oxaloacetate, the anion of oxobutanedioic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
is_a: GO:0015740 ! C4-dicarboxylate transport

[Term]
id: GO:0015730
name: propanoate transport
namespace: biological_process
def: "The directed movement of propionate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
synonym: "propionate transport" EXACT []
is_a: GO:0015912 ! short-chain fatty acid transport

[Term]
id: GO:0015731
name: 3-hydroxyphenyl propanoate transport
namespace: biological_process
def: "The directed movement of 3-hydroxyphenyl propanoate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
synonym: "3-hydroxyphenyl propionate transport" EXACT []
is_a: GO:0015850 ! organic hydroxy compound transport

[Term]
id: GO:0015732
name: prostaglandin transport
namespace: biological_process
def: "The directed movement of prostaglandins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
is_a: GO:0015908 ! fatty acid transport
is_a: GO:0071715 ! icosanoid transport

[Term]
id: GO:0015733
name: shikimate transport
namespace: biological_process
def: "The directed movement of shikimate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
subset: gosubset_prok
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0015850 ! organic hydroxy compound transport

[Term]
id: GO:0015734
name: taurine transport
namespace: biological_process
def: "The directed movement of taurine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
subset: gosubset_prok
is_a: GO:0071702 ! organic substance transport
is_a: GO:0071705 ! nitrogen compound transport
is_a: GO:0072348 ! sulfur compound transport

[Term]
id: GO:0015735
name: uronic acid transport
namespace: biological_process
def: "The directed movement of uronic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
subset: gosubset_prok
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0015749 ! monosaccharide transport

[Term]
id: GO:0015736
name: hexuronate transport
namespace: biological_process
def: "The directed movement of hexuronate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A hexuronate is any monocarboxylic acid derived from a hexose by oxidation of C-6." [GOC:ai, ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0015735 ! uronic acid transport

[Term]
id: GO:0015737
name: galacturonate transport
namespace: biological_process
def: "The directed movement of galacturonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
is_a: GO:0015736 ! hexuronate transport

[Term]
id: GO:0015738
name: glucuronate transport
namespace: biological_process
def: "The directed movement of glucuronate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
is_a: GO:0015736 ! hexuronate transport

[Term]
id: GO:0015739
name: sialic acid transport
namespace: biological_process
def: "The directed movement of sialic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
subset: gosubset_prok
is_a: GO:0046942 ! carboxylic acid transport
is_a: GO:1901264 ! carbohydrate derivative transport

[Term]
id: GO:0015740
name: C4-dicarboxylate transport
namespace: biological_process
def: "The directed movement of a C4-dicarboxylate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A C4-dicarboxylate is the anion of a dicarboxylic acid that contains four carbon atoms." [GOC:krc, GOC:mah]
subset: gosubset_prok
is_a: GO:0006835 ! dicarboxylic acid transport

[Term]
id: GO:0015741
name: fumarate transport
namespace: biological_process
def: "The directed movement of fumarate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
is_a: GO:0015740 ! C4-dicarboxylate transport

[Term]
id: GO:0015742
name: alpha-ketoglutarate transport
namespace: biological_process
def: "The directed movement of alpha-ketoglutarate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
subset: gosubset_prok
synonym: "2-oxoglutarate transport" EXACT []
synonym: "mitochondrial alpha-ketoglutarate/malate transport" RELATED []
is_a: GO:0006835 ! dicarboxylic acid transport

[Term]
id: GO:0015743
name: malate transport
namespace: biological_process
def: "The directed movement of malate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
synonym: "mitochondrial alpha-ketoglutarate/malate transport" RELATED []
is_a: GO:0015740 ! C4-dicarboxylate transport

[Term]
id: GO:0015744
name: succinate transport
namespace: biological_process
def: "The directed movement of succinate, the dianion of ethane dicarboxylic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
subset: gosubset_prok
is_a: GO:0015740 ! C4-dicarboxylate transport

[Term]
id: GO:0015745
name: tartrate transport
namespace: biological_process
def: "The directed movement of tartrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
is_a: GO:0015740 ! C4-dicarboxylate transport
is_a: GO:0042869 ! aldarate transport

[Term]
id: GO:0015746
name: citrate transport
namespace: biological_process
def: "The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
subset: gosubset_prok
is_a: GO:0006842 ! tricarboxylic acid transport

[Term]
id: GO:0015747
name: urate transport
namespace: biological_process
def: "The directed movement of urate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
synonym: "urate transmembrane transport" EXACT [GOC:mah]
synonym: "uric acid transport" EXACT []
is_a: GO:0015711 ! organic anion transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0015748
name: organophosphate ester transport
namespace: biological_process
def: "The directed movement of organophosphate esters into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organophosphate esters are small organic molecules containing phosphate ester bonds." [GOC:mcc]
is_a: GO:0044765 ! single-organism transport
is_a: GO:0071702 ! organic substance transport

[Term]
id: GO:0015749
name: monosaccharide transport
namespace: biological_process
def: "The directed movement of monosaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monosaccharides are the simplest carbohydrates; they are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008643 ! carbohydrate transport

[Term]
id: GO:0015750
name: pentose transport
namespace: biological_process
def: "The directed movement of pentoses into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A pentose is any aldose with a chain of five carbon atoms in the molecule." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015749 ! monosaccharide transport

[Term]
id: GO:0015751
name: arabinose transport
namespace: biological_process
def: "The directed movement of arabinose, a pentose monosaccharide that occurs in both D and L configurations, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:22599, GOC:jl]
subset: gosubset_prok
is_a: GO:0015750 ! pentose transport

[Term]
id: GO:0015752
name: D-ribose transport
namespace: biological_process
def: "The directed movement of D-ribose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. As beta-D-ribofuranose, D-ribose forms the glycose group of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015750 ! pentose transport

[Term]
id: GO:0015753
name: D-xylose transport
namespace: biological_process
def: "The directed movement of D-xylose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. D-xylose (the naturally occurring enantiomer is always D-) is a constituent of plant polysaccharides." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015750 ! pentose transport

[Term]
id: GO:0015754
name: allose transport
namespace: biological_process
def: "The directed movement of allose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Allose is an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008645 ! hexose transport

[Term]
id: GO:0015755
name: fructose transport
namespace: biological_process
def: "The directed movement of fructose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008645 ! hexose transport

[Term]
id: GO:0015756
name: fucose transport
namespace: biological_process
def: "The directed movement of fucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fucose is 6-deoxygalactose and has two enantiomers, D-fucose and L-fucose." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008645 ! hexose transport

[Term]
id: GO:0015757
name: galactose transport
namespace: biological_process
def: "The directed movement of galactose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008645 ! hexose transport

[Term]
id: GO:0015758
name: glucose transport
namespace: biological_process
def: "The directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
xref: Reactome:REACT_100748 "Glucose transport, Schizosaccharomyces pombe"
xref: Reactome:REACT_104861 "Glucose transport, Canis familiaris"
xref: Reactome:REACT_106782 "Glucose transport, Bos taurus"
xref: Reactome:REACT_112521 "Glucose transport, Dictyostelium discoideum"
xref: Reactome:REACT_114803 "Glucose transport, Mycobacterium tuberculosis"
xref: Reactome:REACT_115616 "Glucose transport, Gallus gallus"
xref: Reactome:REACT_212 "Glucose transport, Homo sapiens"
xref: Reactome:REACT_29233 "Glucose transport, Saccharomyces cerevisiae"
xref: Reactome:REACT_29527 "Glucose transport, Gallus gallus"
xref: Reactome:REACT_31046 "Glucose transport, Mus musculus"
xref: Reactome:REACT_34463 "Glucose transport, Drosophila melanogaster"
xref: Reactome:REACT_77150 "Glucose transport, Caenorhabditis elegans"
xref: Reactome:REACT_79237 "Glucose transport, Sus scrofa"
xref: Reactome:REACT_79607 "Glucose transport, Plasmodium falciparum"
xref: Reactome:REACT_83707 "Glucose transport, Xenopus tropicalis"
xref: Reactome:REACT_89807 "Glucose transport, Danio rerio"
xref: Reactome:REACT_94026 "Glucose transport, Arabidopsis thaliana"
xref: Reactome:REACT_97809 "Glucose transport, Rattus norvegicus"
xref: Reactome:REACT_98004 "Glucose transport, Oryza sativa"
xref: Reactome:REACT_98234 "Glucose transport, Taeniopygia guttata"
is_a: GO:0008645 ! hexose transport

[Term]
id: GO:0015759
name: beta-glucoside transport
namespace: biological_process
def: "The directed movement of beta-glucosides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Beta-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in a beta configuration." [GOC:jl, http://www.biochem.purdue.edu/, ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0042946 ! glucoside transport

[Term]
id: GO:0015760
name: glucose-6-phosphate transport
namespace: biological_process
def: "The directed movement of glucose-6-phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glucose-6-phosphate is a monophosphorylated derivative of glucose with the phosphate group attached to C-6." [GOC:ai]
is_a: GO:0015712 ! hexose phosphate transport

[Term]
id: GO:0015761
name: mannose transport
namespace: biological_process
def: "The directed movement of mannose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Mannose is the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008645 ! hexose transport

[Term]
id: GO:0015762
name: rhamnose transport
namespace: biological_process
def: "The directed movement of rhamnose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Rhamnose occurs commonly as a compound of plant glycosides, in polysaccharides of gums and mucilages, and in bacterial polysaccharides. It is also a component of some plant cell wall polysaccharides and frequently acts as the sugar components of flavonoids." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008645 ! hexose transport

[Term]
id: GO:0015763
name: N-acetylgalactosamine transport
namespace: biological_process
def: "The directed movement of N-acetylgalactosamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. N-acetylgalactosamine, 2-acetamido-2-deoxygalactopyranose, is the n-acetyl derivative of galactosamine." [GOC:ai]
subset: gosubset_prok
is_a: GO:1901264 ! carbohydrate derivative transport

[Term]
id: GO:0015764
name: N-acetylglucosamine transport
namespace: biological_process
def: "The directed movement of N-acetylglucosamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
subset: gosubset_prok
is_a: GO:1901264 ! carbohydrate derivative transport

[Term]
id: GO:0015765
name: methylgalactoside transport
namespace: biological_process
def: "The directed movement of methylgalactoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Methylgalactoside is a compound in which the H of the OH group on carbon-1 of galactose is replaced by a methyl group." [CHEBI:55507, GOC:curators]
subset: gosubset_prok
is_a: GO:1901656 ! glycoside transport

[Term]
id: GO:0015766
name: disaccharide transport
namespace: biological_process
def: "The directed movement of disaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Disaccharides are sugars composed of two monosaccharide units." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015772 ! oligosaccharide transport

[Term]
id: GO:0015767
name: lactose transport
namespace: biological_process
def: "The directed movement of lactose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lactose is a disaccharide 4-O-beta-D-galactopyranosyl-D-glucose, and constitutes roughly 5% of the milk in almost all mammals." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015766 ! disaccharide transport

[Term]
id: GO:0015768
name: maltose transport
namespace: biological_process
def: "The directed movement of maltose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the catabolism of glycogen and starch." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015766 ! disaccharide transport

[Term]
id: GO:0015769
name: melibiose transport
namespace: biological_process
def: "The directed movement of melibiose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Melibiose is the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015766 ! disaccharide transport

[Term]
id: GO:0015770
name: sucrose transport
namespace: biological_process
def: "The directed movement of sucrose into, out of or within a cell, or between cells by means of some agent such as a transporter or pore. Sucrose is the disaccharide fructofuranosyl-glucopyranoside." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015766 ! disaccharide transport

[Term]
id: GO:0015771
name: trehalose transport
namespace: biological_process
def: "The directed movement of trehalose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Trehalose is a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015766 ! disaccharide transport

[Term]
id: GO:0015772
name: oligosaccharide transport
namespace: biological_process
def: "The directed movement of oligosaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oligosaccharides are molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008643 ! carbohydrate transport

[Term]
id: GO:0015773
name: raffinose transport
namespace: biological_process
def: "The directed movement of raffinose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Raffinose occurs in plants almost as commonly as sucrose and is present in cereal grains, cotton seeds, and many legumes. It is synthesized from sucrose by transfer of a galactopyranoside from myo-inositol." [ISBN:0198506732]
is_a: GO:2001088 ! trisaccharide transport

[Term]
id: GO:0015774
name: polysaccharide transport
namespace: biological_process
def: "The directed movement of polysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [CHEBI:18154, GOC:ai]
subset: gosubset_prok
is_a: GO:0008643 ! carbohydrate transport
relationship: part_of GO:0033037 ! polysaccharide localization

[Term]
id: GO:0015775
name: beta-glucan transport
namespace: biological_process
def: "The directed movement of beta-glucans into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Beta-glucans are compounds composed of glucose residues linked by beta-glucosidic bonds." [GOC:ai]
is_a: GO:0015774 ! polysaccharide transport

[Term]
id: GO:0015776
name: capsular polysaccharide transport
namespace: biological_process
def: "The directed movement of capsular polysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Capsular polysaccharides make up the capsule, a protective structure surrounding some species of bacteria and fungi." [GOC:ai]
subset: gosubset_prok
synonym: "capsular-polysaccharide transport" EXACT []
synonym: "capsule polysaccharide transport" EXACT []
is_a: GO:0015774 ! polysaccharide transport

[Term]
id: GO:0015777
name: teichoic acid transport
namespace: biological_process
def: "The directed movement of teichoic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Teichoic acid is any polymer occurring in the cell wall, membrane or capsule of Gram-positive bacteria and containing chains of glycerol phosphate or ribitol phosphate residues." [GOC:ai]
subset: gosubset_prok
is_a: GO:1901264 ! carbohydrate derivative transport

[Term]
id: GO:0015778
name: hexuronide transport
namespace: biological_process
def: "The directed movement of hexuronide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Hexuronides are any compound formed by combination of glycosidic linkage of a hydroxy compound (e.g. an alcohol or a saccharide) with the anomeric carbon atom of a hexuronate." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008643 ! carbohydrate transport

[Term]
id: GO:0015779
name: glucuronoside transport
namespace: biological_process
def: "The directed movement of glucuronosides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glucuronosides are any compound formed by combination of glycosidic linkage of a hydroxy compound (e.g. an alcohol or a saccharide) with the anomeric carbon atom of glucuronate." [GOC:ai]
subset: gosubset_prok
synonym: "glucuronide transport" EXACT []
is_a: GO:0046942 ! carboxylic acid transport
is_a: GO:1901656 ! glycoside transport

[Term]
id: GO:0015780
name: nucleotide-sugar transport
namespace: biological_process
def: "The directed movement of nucleotide-sugars into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Nucleotide-sugars are any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [ISBN:0198506732]
is_a: GO:0006862 ! nucleotide transport
is_a: GO:1901264 ! carbohydrate derivative transport

[Term]
id: GO:0015781
name: pyrimidine nucleotide-sugar transport
namespace: biological_process
def: "The directed movement of pyrimidine nucleotide-sugars into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:ai]
is_a: GO:0015780 ! nucleotide-sugar transport

[Term]
id: GO:0015782
name: CMP-N-acetylneuraminate transport
namespace: biological_process
def: "The directed movement of CMP-N-acetylneuraminate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "CMP-sialic acid transport" BROAD []
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015781 ! pyrimidine nucleotide-sugar transport

[Term]
id: GO:0015783
name: GDP-fucose transport
namespace: biological_process
def: "The directed movement of GDP-fucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate." [GOC:ai]
is_a: GO:0036079 ! purine nucleotide-sugar transport

[Term]
id: GO:0015784
name: GDP-mannose transport
namespace: biological_process
def: "The directed movement of GDP-mannose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GDP-mannose is a substance composed of mannose in glycosidic linkage with guanosine diphosphate." [GOC:ai]
is_a: GO:0036079 ! purine nucleotide-sugar transport

[Term]
id: GO:0015785
name: UDP-galactose transport
namespace: biological_process
def: "The directed movement of UDP-galactose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. UDP-galactose is a substance composed of galactose in glycosidic linkage with uridine diphosphate." [GOC:ai]
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015781 ! pyrimidine nucleotide-sugar transport

[Term]
id: GO:0015786
name: UDP-glucose transport
namespace: biological_process
def: "The directed movement of UDP-glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. UDP-glucose is a substance composed of glucose in glycosidic linkage with uridine diphosphate." [GOC:ai]
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015781 ! pyrimidine nucleotide-sugar transport

[Term]
id: GO:0015787
name: UDP-glucuronic acid transport
namespace: biological_process
def: "The directed movement of UDP-glucuronic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. UDP-glucuronic acid is a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate." [GOC:ai]
is_a: GO:0015781 ! pyrimidine nucleotide-sugar transport
is_a: GO:0046942 ! carboxylic acid transport

[Term]
id: GO:0015788
name: UDP-N-acetylglucosamine transport
namespace: biological_process
def: "The directed movement of UDP-N-acetylglucosamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. N-acetylglucosamine is a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai]
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015781 ! pyrimidine nucleotide-sugar transport

[Term]
id: GO:0015789
name: UDP-N-acetylgalactosamine transport
namespace: biological_process
def: "The directed movement of UDP-N-acetylgalactosamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. UDP-N-acetylgalactosamine is a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai]
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015781 ! pyrimidine nucleotide-sugar transport

[Term]
id: GO:0015790
name: UDP-xylose transport
namespace: biological_process
def: "The directed movement of UDP-xylose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. UDP-xylose is a substance composed of xylose in glycosidic linkage with uridine diphosphate." [GOC:ai]
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015781 ! pyrimidine nucleotide-sugar transport

[Term]
id: GO:0015791
name: polyol transport
namespace: biological_process
def: "The directed movement of polyols, any polyhydric alcohol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0015850 ! organic hydroxy compound transport

[Term]
id: GO:0015792
name: arabinitol transport
namespace: biological_process
def: "The directed movement of arabitol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Arabitol is the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. The D enantiomer is present in lichens and mushrooms." [ISBN:0198506732]
synonym: "arabitol transport" RELATED [GOC:dph, GOC:tb]
is_a: GO:0008643 ! carbohydrate transport
is_a: GO:0015791 ! polyol transport

[Term]
id: GO:0015793
name: glycerol transport
namespace: biological_process
def: "The directed movement of glycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai]
subset: gosubset_prok
xref: Reactome:REACT_118071 "Transport of Glycerol from Adipocytes to the Liver by Aquaporins, Sus scrofa"
xref: Reactome:REACT_118082 "Transport of Glycerol from Adipocytes to the Liver by Aquaporins, Plasmodium falciparum"
xref: Reactome:REACT_118123 "Transport of Glycerol from Adipocytes to the Liver by Aquaporins, Bos taurus"
xref: Reactome:REACT_118316 "Transport of Glycerol from Adipocytes to the Liver by Aquaporins, Danio rerio"
xref: Reactome:REACT_118336 "Transport of Glycerol from Adipocytes to the Liver by Aquaporins, Saccharomyces cerevisiae"
xref: Reactome:REACT_118348 "Transport of Glycerol from Adipocytes to the Liver by Aquaporins, Mus musculus"
xref: Reactome:REACT_118362 "Transport of Glycerol from Adipocytes to the Liver by Aquaporins, Staphylococcus aureus N315"
xref: Reactome:REACT_118384 "Transport of Glycerol from Adipocytes to the Liver by Aquaporins, Escherichia coli"
xref: Reactome:REACT_118390 "Transport of Glycerol from Adipocytes to the Liver by Aquaporins, Canis familiaris"
xref: Reactome:REACT_118434 "Transport of Glycerol from Adipocytes to the Liver by Aquaporins, Gallus gallus"
xref: Reactome:REACT_118445 "Transport of Glycerol from Adipocytes to the Liver by Aquaporins, Rattus norvegicus"
xref: Reactome:REACT_118466 "Transport of Glycerol from Adipocytes to the Liver by Aquaporins, Taeniopygia guttata"
xref: Reactome:REACT_118479 "Transport of Glycerol from Adipocytes to the Liver by Aquaporins, Xenopus tropicalis"
xref: Reactome:REACT_118489 "Transport of Glycerol from Adipocytes to the Liver by Aquaporins, Schizosaccharomyces pombe"
xref: Reactome:REACT_23809 "Transport of Glycerol from Adipocytes to the Liver by Aquaporins, Homo sapiens"
is_a: GO:0008643 ! carbohydrate transport
is_a: GO:0015791 ! polyol transport

[Term]
id: GO:0015794
name: glycerol-3-phosphate transport
namespace: biological_process
def: "The directed movement of glycerol-3-phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glycerol-3-phosphate is a phosphoric monoester of glycerol." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015748 ! organophosphate ester transport
is_a: GO:1901264 ! carbohydrate derivative transport

[Term]
id: GO:0015795
name: sorbitol transport
namespace: biological_process
def: "The directed movement of sorbitol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sorbitol, also known as glucitol, is the hexitol derived by the reduction of the aldehyde group of glucose." [GOC:ai, ISBN:0198506732]
subset: gosubset_prok
synonym: "glucitol transport" EXACT []
is_a: GO:0008643 ! carbohydrate transport
is_a: GO:0015791 ! polyol transport

[Term]
id: GO:0015796
name: galactitol transport
namespace: biological_process
def: "The directed movement of galactitol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Galactitol is the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008643 ! carbohydrate transport
is_a: GO:0015791 ! polyol transport

[Term]
id: GO:0015797
name: mannitol transport
namespace: biological_process
def: "The directed movement of mannitol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Mannitol is the alditol derived from D-mannose by reduction of the aldehyde group." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008643 ! carbohydrate transport
is_a: GO:0015791 ! polyol transport

[Term]
id: GO:0015798
name: myo-inositol transport
namespace: biological_process
def: "The directed movement of myo-inositol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Myo-inositol is 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms." [GOC:ai]
subset: gosubset_prok
synonym: "vitamin Bh transport" EXACT []
is_a: GO:0015791 ! polyol transport

[Term]
id: GO:0015799
name: propanediol transport
namespace: biological_process
def: "The directed movement of propanediol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Propanediol is a sweet colorless, viscous, hygroscopic liquid used as an antifreeze and in brake fluid; it is also as a humectant in cosmetics and personal care items, although it can be absorbed through the skin with harmful effects." [http://www.rhymezone.com]
is_a: GO:0015791 ! polyol transport

[Term]
id: GO:0015800
name: acidic amino acid transport
namespace: biological_process
def: "The directed movement of acidic amino acids, amino acids with a pH below 7, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006865 ! amino acid transport

[Term]
id: GO:0015801
name: aromatic amino acid transport
namespace: biological_process
def: "The directed movement of aromatic amino acids, amino acids with aromatic ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006865 ! amino acid transport

[Term]
id: GO:0015802
name: basic amino acid transport
namespace: biological_process
def: "The directed movement of basic amino acids, amino acids with a pH above 7, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006865 ! amino acid transport

[Term]
id: GO:0015803
name: branched-chain amino acid transport
namespace: biological_process
alt_id: GO:1900755
def: "The directed movement of branched-chain amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Branched-chain amino acids are amino acids with a branched carbon skeleton without rings." [CHEBI:22918, GOC:ai, GOC:bf]
subset: gosubset_prok
synonym: "branched-chain aliphatic amino acid transport" EXACT [GOC:curators]
synonym: "branched-chain amino-acid anion transport" EXACT [GOC:jl]
synonym: "branched-chain amino-acid anions transport" RELATED [GOC:TermGenie]
is_a: GO:0006865 ! amino acid transport

[Term]
id: GO:0015804
name: neutral amino acid transport
namespace: biological_process
def: "The directed movement of neutral amino acids, amino acids with no net charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006865 ! amino acid transport

[Term]
id: GO:0015805
name: S-adenosyl-L-methionine transport
namespace: biological_process
def: "The directed movement of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "S-adenosyl methionine transport" EXACT []
synonym: "S-adenosylmethionine transport" EXACT []
synonym: "SAM transport" EXACT []
is_a: GO:0015858 ! nucleoside transport
is_a: GO:0051182 ! coenzyme transport
is_a: GO:0072337 ! modified amino acid transport
is_a: GO:0072348 ! sulfur compound transport

[Term]
id: GO:0015806
name: S-methylmethionine transport
namespace: biological_process
def: "The directed movement of S-methylmethionine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
is_a: GO:0072337 ! modified amino acid transport
is_a: GO:0072348 ! sulfur compound transport

[Term]
id: GO:0015807
name: L-amino acid transport
namespace: biological_process
def: "The directed movement of L-enantiomer amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, GOC:jsg, GOC:mah]
subset: gosubset_prok
is_a: GO:0006865 ! amino acid transport

[Term]
id: GO:0015808
name: L-alanine transport
namespace: biological_process
def: "The directed movement of L-alanine, the L-enantiomer of 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, GOC:jsg, GOC:mah]
subset: gosubset_prok
is_a: GO:0015807 ! L-amino acid transport
is_a: GO:0032328 ! alanine transport

[Term]
id: GO:0015809
name: arginine transport
namespace: biological_process
def: "The directed movement of arginine, 2-amino-5-guanidinopentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "L-arginine transport" NARROW []
is_a: GO:0006812 ! cation transport
is_a: GO:0015802 ! basic amino acid transport

[Term]
id: GO:0015810
name: aspartate transport
namespace: biological_process
def: "The directed movement of aspartate, the anion of aspartic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "mitochondrial aspartate/glutamate transport" RELATED []
is_a: GO:0015740 ! C4-dicarboxylate transport
is_a: GO:0015800 ! acidic amino acid transport

[Term]
id: GO:0015811
name: L-cystine transport
namespace: biological_process
def: "The directed movement of L-cystine (also known as dicysteine) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732]
is_a: GO:0000101 ! sulfur amino acid transport
is_a: GO:0015807 ! L-amino acid transport
is_a: GO:0072337 ! modified amino acid transport

[Term]
id: GO:0015812
name: gamma-aminobutyric acid transport
namespace: biological_process
def: "The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732]
comment: See also the biological process term 'neurotransmitter transport ; GO:0006836'.
subset: gosubset_prok
synonym: "4-aminobutanoate transport" EXACT []
synonym: "4-aminobutyrate transport" EXACT []
synonym: "GABA transport" EXACT []
is_a: GO:0006865 ! amino acid transport
is_a: GO:0015718 ! monocarboxylic acid transport

[Term]
id: GO:0015813
name: L-glutamate transport
namespace: biological_process
def: "The directed movement of L-glutamate, the L enantiomer anion of 2-aminopentanedioic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, GOC:dph, GOC:tb]
subset: gosubset_prok
synonym: "mitochondrial aspartate/glutamate transport" RELATED []
is_a: GO:0006835 ! dicarboxylic acid transport
is_a: GO:0015800 ! acidic amino acid transport
is_a: GO:0015807 ! L-amino acid transport

[Term]
id: GO:0015814
name: p-aminobenzoyl-glutamate transport
namespace: biological_process
def: "The directed movement of p-aminobenzoyl-glutamate, the anion of p-aminobenzoyl-glutamic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006835 ! dicarboxylic acid transport
is_a: GO:0042938 ! dipeptide transport
is_a: GO:0072337 ! modified amino acid transport

[Term]
id: GO:0015816
name: glycine transport
namespace: biological_process
def: "The directed movement of glycine, aminoethanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006812 ! cation transport
is_a: GO:0015804 ! neutral amino acid transport
is_a: GO:0015807 ! L-amino acid transport

[Term]
id: GO:0015817
name: histidine transport
namespace: biological_process
def: "The directed movement of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "L-histidine transport" NARROW []
is_a: GO:0006812 ! cation transport
is_a: GO:0015802 ! basic amino acid transport
is_a: GO:0045117 ! azole transport

[Term]
id: GO:0015818
name: isoleucine transport
namespace: biological_process
def: "The directed movement of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "L-isoleucine transport" NARROW []
is_a: GO:0006812 ! cation transport
is_a: GO:0015803 ! branched-chain amino acid transport
is_a: GO:0015804 ! neutral amino acid transport

[Term]
id: GO:0015819
name: lysine transport
namespace: biological_process
def: "The directed movement of lysine, 2,6-diaminohexanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "L-lysine transport" NARROW []
is_a: GO:0006812 ! cation transport
is_a: GO:0015802 ! basic amino acid transport

[Term]
id: GO:0015820
name: leucine transport
namespace: biological_process
def: "The directed movement of leucine, 2-amino-4-methylpentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "L-leucine transport" NARROW []
is_a: GO:0006812 ! cation transport
is_a: GO:0015803 ! branched-chain amino acid transport
is_a: GO:0015804 ! neutral amino acid transport

[Term]
id: GO:0015821
name: methionine transport
namespace: biological_process
def: "The directed movement of methionine, 2-amino-4-(methylthio)butanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "L-methionine transport" NARROW []
is_a: GO:0000101 ! sulfur amino acid transport
is_a: GO:0006812 ! cation transport

[Term]
id: GO:0015822
name: ornithine transport
namespace: biological_process
def: "The directed movement of ornithine, 2,5-diaminopentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "L-ornithine transport" NARROW []
is_a: GO:0006812 ! cation transport
is_a: GO:0006865 ! amino acid transport

[Term]
id: GO:0015823
name: phenylalanine transport
namespace: biological_process
def: "The directed movement of phenylalanine, 2-amino-3-phenylpropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "L-phenylalanine transport" NARROW []
is_a: GO:0006812 ! cation transport
is_a: GO:0015801 ! aromatic amino acid transport

[Term]
id: GO:0015824
name: proline transport
namespace: biological_process
def: "The directed movement of proline, pyrrolidine-2-carboxylic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "L-proline transport" NARROW []
is_a: GO:0006812 ! cation transport
is_a: GO:0015804 ! neutral amino acid transport

[Term]
id: GO:0015825
name: L-serine transport
namespace: biological_process
def: "The directed movement of L-serine, the L-enantiomer of 2-amino-3-hydroxypropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, GOC:jsg, GOC:mah]
subset: gosubset_prok
is_a: GO:0015807 ! L-amino acid transport
is_a: GO:0032329 ! serine transport

[Term]
id: GO:0015826
name: threonine transport
namespace: biological_process
def: "The directed movement of threonine, (2R*,3S*)-2-amino-3-hydroxybutanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "L-threonine transport" NARROW []
is_a: GO:0006812 ! cation transport
is_a: GO:0015804 ! neutral amino acid transport

[Term]
id: GO:0015827
name: tryptophan transport
namespace: biological_process
def: "The directed movement of tryptophan, 2-amino-3-(1H-indol-3-yl)propanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "L-tryptophan transport" NARROW []
is_a: GO:0006812 ! cation transport
is_a: GO:0015801 ! aromatic amino acid transport

[Term]
id: GO:0015828
name: tyrosine transport
namespace: biological_process
def: "The directed movement of tyrosine, 2-amino-3-(4-hydroxyphenyl)propanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "L-tyrosine transport" NARROW []
is_a: GO:0006812 ! cation transport
is_a: GO:0015801 ! aromatic amino acid transport

[Term]
id: GO:0015829
name: valine transport
namespace: biological_process
def: "The directed movement of valine, 2-amino-3-methylbutanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "L-valine transport" NARROW []
is_a: GO:0006812 ! cation transport
is_a: GO:0015803 ! branched-chain amino acid transport
is_a: GO:0015804 ! neutral amino acid transport

[Term]
id: GO:0015830
name: diaminopimelate transport
namespace: biological_process
def: "The directed movement of diaminopimelate, the anion of 2,6-diaminoheptanedioic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732]
is_a: GO:0006835 ! dicarboxylic acid transport
is_a: GO:0006865 ! amino acid transport

[Term]
id: GO:0015832
name: obsolete holin
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a class of gene products.
synonym: "holin" EXACT []
is_obsolete: true
consider: GO:0008565
consider: GO:0019835

[Term]
id: GO:0015833
name: peptide transport
namespace: biological_process
def: "The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0042886 ! amide transport
is_a: GO:0071702 ! organic substance transport

[Term]
id: GO:0015834
name: peptidoglycan-associated peptide transport
namespace: biological_process
def: "The directed movement of peptidoglycan peptides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Peptidoglycan peptides are the oligopeptides found in peptidoglycan networks which cross-link the polysaccharide chains." [ISBN:0198506732]
subset: gosubset_prok
synonym: "murein peptide transport" EXACT []
synonym: "muropeptide transport" EXACT []
synonym: "peptidoglycan peptide transport" EXACT [GOC:mah]
is_a: GO:0015833 ! peptide transport

[Term]
id: GO:0015835
name: peptidoglycan transport
namespace: biological_process
def: "The directed movement of peptidoglycans, a class of glycoconjugates found in bacterial cell walls, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "murein transport" EXACT []
is_a: GO:0071705 ! nitrogen compound transport
is_a: GO:1901264 ! carbohydrate derivative transport

[Term]
id: GO:0015836
name: lipid-linked peptidoglycan transport
namespace: biological_process
def: "The directed movement of lipid-linked peptidoglycans into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "lipid-linked murein transport" EXACT []
is_a: GO:0015835 ! peptidoglycan transport

[Term]
id: GO:0015837
name: amine transport
namespace: biological_process
def: "The directed movement of amines, including polyamines, organic compounds containing one or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
synonym: "amine/polyamine transport" RELATED []
is_a: GO:0044765 ! single-organism transport
is_a: GO:0071702 ! organic substance transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0015838
name: amino-acid betaine transport
namespace: biological_process
def: "The directed movement of betaine, the N-trimethyl derivative of an amino acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "betaine transport" EXACT []
is_a: GO:0015697 ! quaternary ammonium group transport

[Term]
id: GO:0015839
name: cadaverine transport
namespace: biological_process
def: "The directed movement of cadaverine, 1,5-pentanediamine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015695 ! organic cation transport
is_a: GO:0015696 ! ammonium transport

[Term]
id: GO:0015840
name: urea transport
namespace: biological_process
def: "The directed movement of urea into, out of or within the cell. Urea is the water-soluble compound H2N-CO-NH2." [GOC:ai, ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0019755 ! one-carbon compound transport
is_a: GO:0042886 ! amide transport

[Term]
id: GO:0015841
name: chromaffin granule amine transport
namespace: biological_process
def: "The directed movement of amines into, out of or within chromaffin granules." [GOC:mah]
is_a: GO:0015837 ! amine transport

[Term]
id: GO:0015842
name: aminergic neurotransmitter loading into synaptic vesicle
namespace: biological_process
def: "The active transport of aminergic neurotransmitters into a synaptic vesicle.  This import is fuelled by an electrochemical gradient across the vesicle membrane, established by the action proton pumps." [GOC:ai]
is_a: GO:0015837 ! amine transport
is_a: GO:0098700 ! neurotransmitter loading into synaptic vesicle

[Term]
id: GO:0015843
name: methylammonium transport
namespace: biological_process
def: "The directed movement of methylammonium into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0015695 ! organic cation transport
is_a: GO:0015696 ! ammonium transport
is_a: GO:0015837 ! amine transport
is_a: GO:0019755 ! one-carbon compound transport

[Term]
id: GO:0015844
name: monoamine transport
namespace: biological_process
alt_id: GO:0015873
def: "The directed movement of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:25375, GOC:mah]
subset: gosubset_prok
is_a: GO:0044765 ! single-organism transport
is_a: GO:0071702 ! organic substance transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0015846
name: polyamine transport
namespace: biological_process
def: "The directed movement of polyamines, organic compounds containing two or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc, ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0044765 ! single-organism transport
is_a: GO:0071702 ! organic substance transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0015847
name: putrescine transport
namespace: biological_process
def: "The directed movement of putrescine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Putrescine is 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine." [GOC:krc, ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0015695 ! organic cation transport
is_a: GO:0015696 ! ammonium transport
is_a: GO:0015846 ! polyamine transport

[Term]
id: GO:0015848
name: spermidine transport
namespace: biological_process
def: "The directed movement of spermidine, N-(3-aminopropyl)-1,4-diaminobutane, a polyamine formed by the transfer of a propylamine group from decarboxylated S-adenosylmethionine to putrescine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc, ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0015695 ! organic cation transport
is_a: GO:0015696 ! ammonium transport
is_a: GO:0015846 ! polyamine transport

[Term]
id: GO:0015849
name: organic acid transport
namespace: biological_process
def: "The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0044765 ! single-organism transport
is_a: GO:0071702 ! organic substance transport

[Term]
id: GO:0015850
name: organic hydroxy compound transport
namespace: biological_process
def: "The directed movement of an organic hydroxy compound (organic alcohol) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An organic hydroxy compound is an organic compound having at least one hydroxy group attached to a carbon atom." [CHEBI:33822, GOC:ai]
subset: gosubset_prok
synonym: "organic alcohol transport" EXACT [CHEBI:33822]
is_a: GO:0044765 ! single-organism transport
is_a: GO:0071702 ! organic substance transport

[Term]
id: GO:0015851
name: nucleobase transport
namespace: biological_process
def: "The directed movement of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [ISBN:0198506732]
subset: gosubset_prok
synonym: "nucleobase transmembrane transport" EXACT [GOC:mah]
is_a: GO:0044765 ! single-organism transport
is_a: GO:0071702 ! organic substance transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0015853
name: adenine transport
namespace: biological_process
def: "The directed movement of adenine, 6-aminopurine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732]
synonym: "adenine transmembrane transport" EXACT [GOC:mah]
is_a: GO:0006863 ! purine nucleobase transport

[Term]
id: GO:0015854
name: guanine transport
namespace: biological_process
def: "The directed movement of guanine, 2-amino-6-hydroxypurine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators]
is_a: GO:0006863 ! purine nucleobase transport

[Term]
id: GO:0015855
name: pyrimidine nucleobase transport
namespace: biological_process
def: "The directed movement of pyrimidine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:26432, GOC:ai]
subset: gosubset_prok
synonym: "pyrimidine base transmembrane transport" EXACT [GOC:mah]
synonym: "pyrimidine base transport" EXACT [GOC:go_curators]
synonym: "pyrimidine transmembrane transport" RELATED [GOC:mah]
synonym: "pyrimidine transport" RELATED [GOC:curators]
is_a: GO:0015851 ! nucleobase transport

[Term]
id: GO:0015856
name: cytosine transport
namespace: biological_process
def: "The directed movement of cytosine, 4-amino-2-hydroxypyrimidine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators]
subset: gosubset_prok
synonym: "cytosine transmembrane transport" EXACT [GOC:mah]
is_a: GO:0015855 ! pyrimidine nucleobase transport

[Term]
id: GO:0015857
name: uracil transport
namespace: biological_process
def: "The directed movement of uracil, 2,4-dioxopyrimidine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0015855 ! pyrimidine nucleobase transport

[Term]
id: GO:0015858
name: nucleoside transport
namespace: biological_process
def: "The directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015931 ! nucleobase-containing compound transport
is_a: GO:1901264 ! carbohydrate derivative transport

[Term]
id: GO:0015859
name: intracellular nucleoside transport
namespace: biological_process
def: "The directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide), within a cell." [GOC:ai]
is_a: GO:0015858 ! nucleoside transport
is_a: GO:1902582 ! single-organism intracellular transport
intersection_of: GO:0015858 ! nucleoside transport
intersection_of: occurs_in GO:0005622 ! intracellular
relationship: occurs_in GO:0005622 ! intracellular

[Term]
id: GO:0015860
name: purine nucleoside transmembrane transport
namespace: biological_process
alt_id: GO:0035427
def: "The directed movement of a purine nucleoside across a membrane. A purine nucleoside is a purine base covalently bonded to a ribose or deoxyribose sugar." [GOC:ai, GOC:vw]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
subset: gosubset_prok
synonym: "purine nucleoside membrane transport" EXACT []
synonym: "purine nucleoside transport" BROAD [GOC:vw]
is_a: GO:0072530 ! purine-containing compound transmembrane transport
is_a: GO:1901642 ! nucleoside transmembrane transport

[Term]
id: GO:0015861
name: cytidine transport
namespace: biological_process
def: "The directed movement of cytidine, cytosine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators]
is_a: GO:0015864 ! pyrimidine nucleoside transport

[Term]
id: GO:0015862
name: uridine transport
namespace: biological_process
def: "The directed movement of uridine, uracil riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators]
is_a: GO:0015864 ! pyrimidine nucleoside transport

[Term]
id: GO:0015863
name: xanthosine transport
namespace: biological_process
def: "The directed movement of xanthosine, xanthine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0015858 ! nucleoside transport

[Term]
id: GO:0015864
name: pyrimidine nucleoside transport
namespace: biological_process
def: "The directed movement of a pyrimidine nucleoside, a pyrimidine base covalently bonded to a ribose or deoxyribose sugar, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0015858 ! nucleoside transport

[Term]
id: GO:0015865
name: purine nucleotide transport
namespace: biological_process
def: "The directed movement of a purine nucleotide, any compound consisting of a purine nucleoside esterified with (ortho)phosphate, into, out of or within a cell." [GOC:ai]
is_a: GO:0006862 ! nucleotide transport

[Term]
id: GO:0015866
name: ADP transport
namespace: biological_process
def: "The directed movement of ADP, adenosine diphosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015858 ! nucleoside transport
is_a: GO:0015868 ! purine ribonucleotide transport
is_a: GO:0051503 ! adenine nucleotide transport

[Term]
id: GO:0015867
name: ATP transport
namespace: biological_process
def: "The directed movement of ATP, adenosine triphosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015858 ! nucleoside transport
is_a: GO:0015868 ! purine ribonucleotide transport
is_a: GO:0051503 ! adenine nucleotide transport

[Term]
id: GO:0015868
name: purine ribonucleotide transport
namespace: biological_process
def: "The directed movement of a purine ribonucleotide, any compound consisting of a purine ribonucleoside (a purine organic base attached to a ribose sugar) esterified with (ortho)phosphate, into, out of or within a cell." [GOC:ai]
is_a: GO:0015865 ! purine nucleotide transport
is_a: GO:1901264 ! carbohydrate derivative transport

[Term]
id: GO:0015869
name: protein-DNA complex transport
namespace: biological_process
def: "The directed movement of protein-DNA complexes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "DNA-protein complex transport" EXACT [GOC:mah]
is_a: GO:0006886 ! intracellular protein transport
is_a: GO:0051027 ! DNA transport
is_a: GO:1902582 ! single-organism intracellular transport

[Term]
id: GO:0015870
name: acetylcholine transport
namespace: biological_process
def: "The directed movement of acetylcholine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions." [GOC:ai]
is_a: GO:0015696 ! ammonium transport
is_a: GO:1901374 ! acetate ester transport

[Term]
id: GO:0015871
name: choline transport
namespace: biological_process
def: "The directed movement of choline into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine." [GOC:ai]
is_a: GO:0015696 ! ammonium transport
is_a: GO:0015850 ! organic hydroxy compound transport

[Term]
id: GO:0015872
name: dopamine transport
namespace: biological_process
def: "The directed movement of dopamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:ai]
is_a: GO:0015696 ! ammonium transport
is_a: GO:0051937 ! catecholamine transport

[Term]
id: GO:0015874
name: norepinephrine transport
namespace: biological_process
def: "The directed movement of norepinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine." [GOC:ai, ISBN:0198506732]
synonym: "levarterenol transport" EXACT []
synonym: "noradrenaline transport" EXACT []
is_a: GO:0051937 ! catecholamine transport

[Term]
id: GO:0015875
name: obsolete vitamin or cofactor transport
namespace: biological_process
def: "OBSOLETE. The directed movement of vitamins or cofactors into, out of or within a cell, or between cells." [GOC:ai]
comment: This term was made obsolete because it was replaced by more specific terms.
synonym: "vitamin or cofactor transport" EXACT []
is_obsolete: true
consider: GO:0051180
consider: GO:0051181

[Term]
id: GO:0015876
name: acetyl-CoA transport
namespace: biological_process
def: "The directed movement of acetyl-CoA into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis." [GOC:ai]
is_a: GO:0015916 ! fatty-acyl-CoA transport
is_a: GO:0051182 ! coenzyme transport

[Term]
id: GO:0015877
name: biopterin transport
namespace: biological_process
def: "The directed movement of biopterin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Biopterin is a growth factor for certain protozoans and some insects; it is widely distributed in tissues and functions in a reduced form, tetrahydrobiopterin, as a hydroxylation coenzyme." [GOC:ai]
is_a: GO:0051181 ! cofactor transport
is_a: GO:0071702 ! organic substance transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0015878
name: biotin transport
namespace: biological_process
def: "The directed movement of biotin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Biotin is cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions." [GOC:ai]
synonym: "vitamin B7 transport" EXACT []
synonym: "vitamin H transport" EXACT []
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0042886 ! amide transport
is_a: GO:0051180 ! vitamin transport
is_a: GO:0051181 ! cofactor transport
is_a: GO:0072348 ! sulfur compound transport

[Term]
id: GO:0015879
name: carnitine transport
namespace: biological_process
def: "The directed movement of carnitine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:ai]
subset: gosubset_prok
synonym: "vitamin Bt transport" EXACT []
is_a: GO:0015696 ! ammonium transport
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0015838 ! amino-acid betaine transport
is_a: GO:0015850 ! organic hydroxy compound transport

[Term]
id: GO:0015880
name: coenzyme A transport
namespace: biological_process
def: "The directed movement of coenzyme A into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [GOC:ai]
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015858 ! nucleoside transport
is_a: GO:0015868 ! purine ribonucleotide transport
is_a: GO:0051182 ! coenzyme transport
is_a: GO:0051503 ! adenine nucleotide transport

[Term]
id: GO:0015881
name: creatine transport
namespace: biological_process
def: "The directed movement of creatine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Creatine is a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle." [GOC:ai]
is_a: GO:0006865 ! amino acid transport
is_a: GO:0072337 ! modified amino acid transport

[Term]
id: GO:0015882
name: L-ascorbic acid transport
namespace: biological_process
def: "The directed movement of L-ascorbic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, is vitamin C and has co-factor and anti-oxidant activities in many species." [CHEBI:38290, GOC:ai]
synonym: "L-ascorbate transport" EXACT []
synonym: "vitamin C transport" EXACT []
is_a: GO:0015749 ! monosaccharide transport
is_a: GO:0046942 ! carboxylic acid transport
is_a: GO:0051180 ! vitamin transport

[Term]
id: GO:0015883
name: FAD transport
namespace: biological_process
def: "The directed movement of flavin-adenine dinucleotide (FAD) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. FAD forms the coenzyme of the prosthetic group of various flavoprotein oxidoreductase enzymes, in which it functions as an electron acceptor by being reversibly converted to its reduced form." [ISBN:0198506732]
synonym: "flavin adenine dinucleotide transport" EXACT []
synonym: "flavin-adenine dinucleotide transport" EXACT []
is_a: GO:0006862 ! nucleotide transport
is_a: GO:0015711 ! organic anion transport
is_a: GO:0051182 ! coenzyme transport

[Term]
id: GO:0015884
name: folic acid transport
namespace: biological_process
def: "The directed movement of folic acid (pteroylglutamic acid) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines." [GOC:ai]
synonym: "folate transport" EXACT []
synonym: "vitamin B9 transport" EXACT []
synonym: "vitamin M transport" EXACT []
is_a: GO:0006835 ! dicarboxylic acid transport
is_a: GO:0006865 ! amino acid transport
is_a: GO:0042886 ! amide transport
is_a: GO:0051180 ! vitamin transport
is_a: GO:0051181 ! cofactor transport
is_a: GO:0072337 ! modified amino acid transport

[Term]
id: GO:0015885
name: 5-formyltetrahydrofolate transport
namespace: biological_process
def: "The directed movement of 5-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate, into, out of, within, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0006835 ! dicarboxylic acid transport
is_a: GO:0006865 ! amino acid transport
is_a: GO:0042886 ! amide transport
is_a: GO:0051181 ! cofactor transport
is_a: GO:0072337 ! modified amino acid transport

[Term]
id: GO:0015886
name: heme transport
namespace: biological_process
def: "The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "haem transport" EXACT []
is_a: GO:0051181 ! cofactor transport
is_a: GO:0071702 ! organic substance transport
is_a: GO:0071705 ! nitrogen compound transport
is_a: GO:1901678 ! iron coordination entity transport

[Term]
id: GO:0015887
name: pantothenate transmembrane transport
namespace: biological_process
def: "The directed movement of pantothenate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Pantothenate is the anion of pantothenic acid, the amide of beta-alanine and pantoic acid; it is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods." [GOC:ai, ISBN:0721662544]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
subset: gosubset_prok
synonym: "pantothenate membrane transport" EXACT []
synonym: "pantothenate transport" EXACT [GOC:mah]
synonym: "vitamin B5 transport" EXACT []
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0035461 ! vitamin transmembrane transport
is_a: GO:0042886 ! amide transport
is_a: GO:0051182 ! coenzyme transport
is_a: GO:0072337 ! modified amino acid transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport

[Term]
id: GO:0015888
name: thiamine transport
namespace: biological_process
def: "The directed movement of thiamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:ai]
subset: gosubset_prok
synonym: "thiamin transport" EXACT [GOC:curators]
synonym: "vitamin B1 transport" EXACT []
is_a: GO:0045117 ! azole transport
is_a: GO:0051180 ! vitamin transport
is_a: GO:0072348 ! sulfur compound transport

[Term]
id: GO:0015889
name: cobalamin transport
namespace: biological_process
def: "The directed movement of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "vitamin B12 transport" EXACT []
is_a: GO:0051180 ! vitamin transport
is_a: GO:0071702 ! organic substance transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0015890
name: nicotinamide mononucleotide transport
namespace: biological_process
def: "The directed movement of nicotinamide mononucleotide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Nicotinamide mononucleotide is a ribonucleotide in which the nitrogenous base, nicotinamide, is in beta-n-glycosidic linkage with the c-1 position of D-ribose. It is a constituent of NAD and NADP." [CHEBI:50383, GOC:curators, ISBN:0721662544]
subset: gosubset_prok
synonym: "nicotinamide ribonucleotide transport" EXACT []
is_a: GO:0006862 ! nucleotide transport
is_a: GO:0051181 ! cofactor transport
is_a: GO:1901264 ! carbohydrate derivative transport

[Term]
id: GO:0015891
name: siderophore transport
namespace: biological_process
alt_id: GO:0015892
def: "The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "iron-siderochrome transport" NARROW []
synonym: "iron-siderophore transport" EXACT []
synonym: "siderochrome transport" NARROW []
synonym: "siderophore-iron transport" EXACT []
is_a: GO:0015688 ! iron chelate transport
is_a: GO:0051649 ! establishment of localization in cell

[Term]
id: GO:0015893
name: drug transport
namespace: biological_process
def: "The directed movement of a drug, a substance used in the diagnosis, treatment or prevention of a disease, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0044765 ! single-organism transport
relationship: part_of GO:0042493 ! response to drug

[Term]
id: GO:0015894
name: acriflavine transport
namespace: biological_process
def: "The directed movement of acriflavine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acriflavine is a fluorescent dye used as a local antiseptic and also as a biological stain. It intercalates into nucleic acids thereby inhibiting bacterial and viral replication." [GOC:curators, PubChem_Compound:6842]
synonym: "acriflavin transport" RELATED [GOC:dph, GOC:tb]
is_a: GO:0015893 ! drug transport
is_a: GO:0042908 ! xenobiotic transport

[Term]
id: GO:0015895
name: alkane transport
namespace: biological_process
def: "The directed movement of alkanes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Alkanes are saturated aliphatic hydrocarbon compounds." [GOC:ai]
is_a: GO:0044765 ! single-organism transport
is_a: GO:0071702 ! organic substance transport

[Term]
id: GO:0015896
name: nalidixic acid transport
namespace: biological_process
def: "The directed movement of nalidixic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Nalidixic acid is a synthetic antibiotic that interferes with DNA gyrase and inhibits prokaryotic replication." [GOC:curators, PMID:12702699, PubChem_Compound:4221]
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0042891 ! antibiotic transport
is_a: GO:0042908 ! xenobiotic transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0015897
name: organomercurial transport
namespace: biological_process
def: "The directed movement of organomercurial compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organomercurial substances are any organic compound containing a mercury atom." [GOC:ai]
is_a: GO:0015893 ! drug transport
is_a: GO:0071702 ! organic substance transport

[Term]
id: GO:0015898
name: amiloride transport
namespace: biological_process
def: "The directed movement amiloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Amiloride is a potent and specific inhibitor of sodium ion entry into cells. It is used as a potassium-sparing diuretic." [GOC:ai]
is_a: GO:0015893 ! drug transport
is_a: GO:0042886 ! amide transport
is_a: GO:0071702 ! organic substance transport

[Term]
id: GO:0015899
name: aminotriazole transport
namespace: biological_process
def: "The directed movement of aminotriazole into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Aminotriazole is an effective weed killer that also possesses some antithyroid activity." [CHEBI:40036, GOC:curators]
is_a: GO:0015837 ! amine transport
is_a: GO:0045117 ! azole transport

[Term]
id: GO:0015900
name: benomyl transport
namespace: biological_process
def: "The directed movement of benomyl into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Benomyl, methyl 1-(butylcarbamoyl)-2-benzimidazolecarbamate, is a systemic agricultural fungicide used for control of certain fungal diseases of stone fruit." [CHEBI:3015, GOC:curators]
is_a: GO:0015893 ! drug transport
is_a: GO:0042886 ! amide transport
is_a: GO:0042908 ! xenobiotic transport
is_a: GO:0071702 ! organic substance transport

[Term]
id: GO:0015901
name: cycloheximide transport
namespace: biological_process
def: "The directed movement of cycloheximide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Cycloheximide is an antibiotic produced by Streptomyces which interferes with protein synthesis in eukaryotes." [ISBN:0198506732]
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0042886 ! amide transport
is_a: GO:0042891 ! antibiotic transport

[Term]
id: GO:0015902
name: carbonyl cyanide m-chlorophenylhydrazone transport
namespace: biological_process
def: "The directed movement of carbonyl cyanide m-chlorophenylhydrazone into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbonyl cyanide m-chlorophenylhydrazone is a proton ionophore, commonly used as an uncoupling agent and inhibitor of photosynthesis because of its effects on mitochondrial and chloroplast membranes." [CHEBI:3259, GOC:curators]
synonym: "CCCP transport" EXACT []
is_a: GO:0015893 ! drug transport
is_a: GO:0071702 ! organic substance transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0015903
name: fluconazole transport
namespace: biological_process
def: "The directed movement of fluconazole into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fluconazole is an antifungal drug used for oral candidiasis and cryptococcal meningitis; it is still under study for treatment of vaginal candidiasis and other fungal infections." [CHEBI:46081, GOC:curators]
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0045117 ! azole transport

[Term]
id: GO:0015904
name: tetracycline transport
namespace: biological_process
def: "The directed movement of tetracycline into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles)." [CHEBI:27902, GOC:curators]
subset: gosubset_prok
synonym: "tetracyclin transport" EXACT []
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0042891 ! antibiotic transport

[Term]
id: GO:0015905
name: bicyclomycin transport
namespace: biological_process
def: "The directed movement of bicyclomycin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Bicyclomycin (or bicozamycin) is an antibacterial drug often used as a livestock feed additive." [ISBN:91191028X]
subset: gosubset_prok
is_a: GO:0042891 ! antibiotic transport
is_a: GO:0071702 ! organic substance transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0015906
name: sulfathiazole transport
namespace: biological_process
def: "The directed movement of sulfathiazole into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sulfathiazole is an antibacterial agent of the sulfonamide group." [CHEBI:9337, GOC:curators]
synonym: "sulphathiazole transport" EXACT []
is_a: GO:0042886 ! amide transport
is_a: GO:0045117 ! azole transport
is_a: GO:0072348 ! sulfur compound transport

[Term]
id: GO:0015908
name: fatty acid transport
namespace: biological_process
def: "The directed movement of fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006869 ! lipid transport
is_a: GO:0015718 ! monocarboxylic acid transport

[Term]
id: GO:0015909
name: long-chain fatty acid transport
namespace: biological_process
def: "The directed movement of long-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [CHEBI:15904, GOC:ai]
subset: gosubset_prok
xref: Reactome:REACT_23892 "Transport of fatty acids, Homo sapiens"
is_a: GO:0015908 ! fatty acid transport

[Term]
id: GO:0015910
name: peroxisomal long-chain fatty acid import
namespace: biological_process
def: "The directed movement of long-chain fatty acids into a peroxisome. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [CHEBI:15904, GOC:ai]
synonym: "peroxisomal long-chain fatty acid uptake" EXACT [GOC:dph, GOC:tb]
is_a: GO:0015909 ! long-chain fatty acid transport

[Term]
id: GO:0015911
name: plasma membrane long-chain fatty acid transport
namespace: biological_process
def: "The directed movement of long-chain fatty acids across the plasma membrane. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [CHEBI:15904, GOC:ai]
is_a: GO:0015909 ! long-chain fatty acid transport
is_a: GO:1902001 ! fatty acid transmembrane transport

[Term]
id: GO:0015912
name: short-chain fatty acid transport
namespace: biological_process
def: "The directed movement of short-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Short-chain fatty acids are fatty acids with a chain length of less than C6." [CHEBI:26666, GOC:ai]
subset: gosubset_prok
is_a: GO:0015908 ! fatty acid transport

[Term]
id: GO:0015913
name: short-chain fatty acid import
namespace: biological_process
def: "The directed movement of short-chain fatty acids into a cell or organelle. Short-chain fatty acids are fatty acids with a chain length of less than C6." [CHEBI:26666, GOC:ai]
synonym: "short-chain fatty acid uptake" EXACT []
is_a: GO:0015912 ! short-chain fatty acid transport

[Term]
id: GO:0015914
name: phospholipid transport
namespace: biological_process
def: "The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006869 ! lipid transport
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015748 ! organophosphate ester transport

[Term]
id: GO:0015915
name: fatty-acyl group transport
namespace: biological_process
def: "The directed movement of fatty acyl groups into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A fatty acyl group is any acyl group derived from a fatty acid." [GOC:ai]
synonym: "fatty acyl transport" EXACT [GOC:curators]
is_a: GO:0044765 ! single-organism transport

[Term]
id: GO:0015916
name: fatty-acyl-CoA transport
namespace: biological_process
def: "The directed movement of fatty acyl coenzyme A into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fatty acyl coenzyme A is an acyl group linked to 3'-phosphoadenosine-(5')diphospho(4')pantatheine (coenzyme A)." [GOC:ai, ISBN:0198506732]
synonym: "fatty acyl CoA transport" EXACT [GOC:curators]
synonym: "fatty acyl coenzyme A transport" EXACT []
synonym: "fatty acyl-CoA transport" EXACT []
is_a: GO:0015711 ! organic anion transport
is_a: GO:1901337 ! thioester transport

[Term]
id: GO:0015917
name: aminophospholipid transport
namespace: biological_process
def: "The directed movement of aminophospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Aminophospholipids contain phosphoric acid as a mono- or diester and an amino (NH2) group." [GOC:ai]
is_a: GO:0015914 ! phospholipid transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0015918
name: sterol transport
namespace: biological_process
def: "The directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:ai]
xref: Reactome:REACT_103237 "Trafficking of dietary sterols, Taeniopygia guttata"
xref: Reactome:REACT_105697 "Trafficking of dietary sterols, Danio rerio"
xref: Reactome:REACT_111982 "Trafficking of dietary sterols, Plasmodium falciparum"
xref: Reactome:REACT_114213 "Trafficking of dietary sterols, Mycobacterium tuberculosis"
xref: Reactome:REACT_13781 "Trafficking of dietary sterols, Homo sapiens"
xref: Reactome:REACT_28837 "Trafficking of dietary sterols, Bos taurus"
xref: Reactome:REACT_28881 "Trafficking of dietary sterols, Caenorhabditis elegans"
xref: Reactome:REACT_33323 "Trafficking of dietary sterols, Dictyostelium discoideum"
xref: Reactome:REACT_49006 "Trafficking of dietary sterols, Rattus norvegicus"
xref: Reactome:REACT_81755 "Trafficking of dietary sterols, Sus scrofa"
xref: Reactome:REACT_83389 "Trafficking of dietary sterols, Canis familiaris"
xref: Reactome:REACT_85624 "Trafficking of dietary sterols, Gallus gallus"
xref: Reactome:REACT_90788 "Trafficking of dietary sterols, Saccharomyces cerevisiae"
xref: Reactome:REACT_91234 "Trafficking of dietary sterols, Oryza sativa"
xref: Reactome:REACT_93019 "Trafficking of dietary sterols, Drosophila melanogaster"
xref: Reactome:REACT_93344 "Trafficking of dietary sterols, Mus musculus"
xref: Reactome:REACT_94184 "Trafficking of dietary sterols, Xenopus tropicalis"
xref: Reactome:REACT_96633 "Trafficking of dietary sterols, Arabidopsis thaliana"
is_a: GO:0006869 ! lipid transport
is_a: GO:0015850 ! organic hydroxy compound transport

[Term]
id: GO:0015919
name: peroxisomal membrane transport
namespace: biological_process
def: "The directed movement of substances to, from or across the peroxisomal membrane." [GOC:ai]
is_a: GO:0043574 ! peroxisomal transport

[Term]
id: GO:0015920
name: lipopolysaccharide transport
namespace: biological_process
def: "The directed movement of lipopolysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "LPS transport" EXACT []
is_a: GO:0006869 ! lipid transport
is_a: GO:1901264 ! carbohydrate derivative transport

[Term]
id: GO:0015921
name: lipopolysaccharide export
namespace: biological_process
def: "The directed movement of lipopolysaccharides out of a cell or organelle." [GOC:ai]
subset: gosubset_prok
synonym: "LPS export" EXACT []
is_a: GO:0015920 ! lipopolysaccharide transport

[Term]
id: GO:0015922
name: aspartate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: aspartate + O2 = iminosuccinate + hydrogen peroxide." [EC:1.4.3.1, EC:1.4.3.16]
subset: gosubset_prok
xref: EC:1.4.3.-
is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

[Term]
id: GO:0015923
name: mannosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cyclic form of mannose or a mannose derivative." [GOC:ai]
subset: gosubset_prok
xref: EC:3.2.1.-
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0015924
name: mannosyl-oligosaccharide mannosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the terminal alpha-D-mannose residues in oligo-mannose oligosaccharides." [EC:3.2.1.-, GOC:ai]
subset: gosubset_prok
xref: EC:3.2.1.-
is_a: GO:0004559 ! alpha-mannosidase activity

[Term]
id: GO:0015925
name: galactosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of galactosyl compounds, substances containing a group derived from a cyclic form of galactose or a galactose derivative." [GOC:ai]
subset: gosubset_prok
xref: EC:3.2.1.-
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0015926
name: glucosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of glucosyl compounds, substances containing a group derived from a cyclic form of glucose or a glucose derivative." [ISBN:0198506732]
subset: gosubset_prok
xref: EC:3.2.1.-
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0015927
name: trehalase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of trehalose or a trehalose derivative." [GOC:ai]
subset: gosubset_prok
xref: EC:3.2.1.-
xref: MetaCyc:TREHALA-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0015928
name: fucosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of fucosyl compounds, substances containing a group derived from a cyclic form of fucose or a fucose derivative." [GOC:ai]
subset: gosubset_prok
xref: EC:3.2.1.-
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0015929
name: hexosaminidase activity
namespace: molecular_function
def: "Catalysis of the cleavage of hexosamine or N-acetylhexosamine residues (e.g. N-acetylglucosamine) residues from gangliosides or other glycoside oligosaccharides." [http://www.onelook.com/, ISBN:0721662544]
subset: gosubset_prok
xref: EC:3.2.1.-
xref: MetaCyc:3.2.1.52-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0015930
name: glutamate synthase activity
namespace: molecular_function
def: "Catalysis of the formation of L-glutamine and 2-oxoglutarate from L-glutamate, using NADH, NADPH or ferredoxin as hydrogen acceptors." [EC:1.4.-.-]
subset: gosubset_prok
xref: EC:1.4.-.-
is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors

[Term]
id: GO:0015931
name: nucleobase-containing compound transport
namespace: biological_process
def: "The directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid transport" RELATED [GOC:dph, GOC:tb]
is_a: GO:0071702 ! organic substance transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0015932
name: nucleobase-containing compound transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of nucleobases, nucleosides, nucleotides and nucleic acids from one side of a membrane to the other." [GOC:ai]
subset: gosubset_prok
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity" RELATED [GOC:dph, GOC:tb]
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity
relationship: part_of GO:0015931 ! nucleobase-containing compound transport

[Term]
id: GO:0015933
name: obsolete flavin-containing electron transporter
namespace: molecular_function
def: "OBSOLETE. An oxidoreductase which contains either flavin-adenine dinucleotide or flavin mononucleotide as a prosthetic group, utilizes either NADH or NADPH and transfers electrons to other electron transfer proteins." [GOC:kd]
comment: This term was made obsolete because it does not describe a molecular function.
synonym: "flavin-containing electron transporter" EXACT []
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0015934
name: large ribosomal subunit
namespace: cellular_component
def: "The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]
subset: gosubset_prok
synonym: "ribosomal large subunit" EXACT []
is_a: GO:0044391 ! ribosomal subunit

[Term]
id: GO:0015935
name: small ribosomal subunit
namespace: cellular_component
def: "The smaller of the two subunits of a ribosome." [GOC:mah]
subset: goslim_pir
subset: gosubset_prok
synonym: "ribosomal small subunit" EXACT []
is_a: GO:0044391 ! ribosomal subunit

[Term]
id: GO:0015936
name: coenzyme A metabolic process
namespace: biological_process
alt_id: GO:0006763
def: "The chemical reactions and pathways involving coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [ISBN:0198547684]
subset: gosubset_prok
synonym: "CoA metabolism" EXACT []
synonym: "coenzyme A metabolism" EXACT []
is_a: GO:0006732 ! coenzyme metabolic process
is_a: GO:0009150 ! purine ribonucleotide metabolic process
is_a: GO:0033875 ! ribonucleoside bisphosphate metabolic process
is_a: GO:0034032 ! purine nucleoside bisphosphate metabolic process
is_a: GO:0046128 ! purine ribonucleoside metabolic process

[Term]
id: GO:0015937
name: coenzyme A biosynthetic process
namespace: biological_process
alt_id: GO:0006764
def: "The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [ISBN:0198547684]
subset: gosubset_prok
synonym: "CoA biosynthesis" EXACT []
synonym: "coenzyme A anabolism" EXACT []
synonym: "coenzyme A biosynthesis" EXACT []
synonym: "coenzyme A formation" EXACT []
synonym: "coenzyme A synthesis" EXACT []
xref: MetaCyc:COA-PWY
xref: MetaCyc:PANTOSYN-PWY
xref: MetaCyc:PWY-4221
is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0009152 ! purine ribonucleotide biosynthetic process
is_a: GO:0015936 ! coenzyme A metabolic process
is_a: GO:0034030 ! ribonucleoside bisphosphate biosynthetic process
is_a: GO:0034033 ! purine nucleoside bisphosphate biosynthetic process
is_a: GO:0046129 ! purine ribonucleoside biosynthetic process

[Term]
id: GO:0015938
name: coenzyme A catabolic process
namespace: biological_process
alt_id: GO:0006765
def: "The chemical reactions and pathways resulting in the breakdown of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [ISBN:0198547684]
subset: gosubset_prok
synonym: "CoA catabolism" EXACT []
synonym: "coenzyme A breakdown" EXACT []
synonym: "coenzyme A catabolism" EXACT []
synonym: "coenzyme A degradation" EXACT []
is_a: GO:0009109 ! coenzyme catabolic process
is_a: GO:0009154 ! purine ribonucleotide catabolic process
is_a: GO:0015936 ! coenzyme A metabolic process
is_a: GO:0034031 ! ribonucleoside bisphosphate catabolic process
is_a: GO:0034034 ! purine nucleoside bisphosphate catabolic process
is_a: GO:0046130 ! purine ribonucleoside catabolic process

[Term]
id: GO:0015939
name: pantothenate metabolic process
namespace: biological_process
alt_id: GO:0006770
def: "The chemical reactions and pathways involving pantothenate, the anion of pantothenic acid, the amide of beta-alanine and pantoic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods." [GOC:ai, ISBN:0721662544]
subset: gosubset_prok
synonym: "pantothenate metabolism" EXACT []
synonym: "vitamin B5 metabolic process" EXACT []
synonym: "vitamin B5 metabolism" EXACT []
xref: Reactome:REACT_103358 "Vitamin B5 (pantothenate) metabolism, Gallus gallus"
xref: Reactome:REACT_104492 "Vitamin B5 (pantothenate) metabolism, Plasmodium falciparum"
xref: Reactome:REACT_105528 "Vitamin B5 (pantothenate) metabolism, Oryza sativa"
xref: Reactome:REACT_106249 "Vitamin B5 (pantothenate) metabolism, Mus musculus"
xref: Reactome:REACT_108156 "Vitamin B5 (pantothenate) metabolism, Xenopus tropicalis"
xref: Reactome:REACT_108431 "Vitamin B5 (pantothenate) metabolism, Arabidopsis thaliana"
xref: Reactome:REACT_110397 "Vitamin B5 (pantothenate) metabolism, Danio rerio"
xref: Reactome:REACT_110826 "Vitamin B5 (pantothenate) metabolism, Drosophila melanogaster"
xref: Reactome:REACT_110973 "Vitamin B5 (pantothenate) metabolism, Staphylococcus aureus N315"
xref: Reactome:REACT_11172 "Vitamin B5 (pantothenate) metabolism, Homo sapiens"
xref: Reactome:REACT_28656 "Vitamin B5 (pantothenate) metabolism, Bos taurus"
xref: Reactome:REACT_30617 "Vitamin B5 (pantothenate) metabolism, Saccharomyces cerevisiae"
xref: Reactome:REACT_82950 "Vitamin B5 (pantothenate) metabolism, Escherichia coli"
xref: Reactome:REACT_83019 "Vitamin B5 (pantothenate) metabolism, Schizosaccharomyces pombe"
xref: Reactome:REACT_83248 "Vitamin B5 (pantothenate) metabolism, Caenorhabditis elegans"
xref: Reactome:REACT_86752 "Vitamin B5 (pantothenate) metabolism, Taeniopygia guttata"
xref: Reactome:REACT_86839 "Vitamin B5 (pantothenate) metabolism, Sus scrofa"
xref: Reactome:REACT_87697 "Vitamin B5 (pantothenate) metabolism, Rattus norvegicus"
xref: Reactome:REACT_89166 "Vitamin B5 (pantothenate) metabolism, Mycobacterium tuberculosis"
xref: Reactome:REACT_92560 "Vitamin B5 (pantothenate) metabolism, Canis familiaris"
xref: Reactome:REACT_93339 "Vitamin B5 (pantothenate) metabolism, Dictyostelium discoideum"
is_a: GO:0006575 ! cellular modified amino acid metabolic process
is_a: GO:0006732 ! coenzyme metabolic process
is_a: GO:0006767 ! water-soluble vitamin metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0043603 ! cellular amide metabolic process

[Term]
id: GO:0015940
name: pantothenate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods." [GOC:ai, ISBN:0721662544]
subset: gosubset_prok
synonym: "pantothenate anabolism" EXACT []
synonym: "pantothenate biosynthesis" EXACT []
synonym: "pantothenate formation" EXACT []
synonym: "pantothenate synthesis" EXACT []
synonym: "vitamin B5 biosynthesis" EXACT []
synonym: "vitamin B5 biosynthetic process" EXACT []
xref: MetaCyc:PANTOSYN-PWY
xref: MetaCyc:PWY-4221
is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0015939 ! pantothenate metabolic process
is_a: GO:0042364 ! water-soluble vitamin biosynthetic process
is_a: GO:0042398 ! cellular modified amino acid biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process

[Term]
id: GO:0015941
name: pantothenate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods." [GOC:ai, ISBN:0721662544]
subset: gosubset_prok
synonym: "pantothenate breakdown" EXACT []
synonym: "pantothenate catabolism" EXACT []
synonym: "pantothenate degradation" EXACT []
synonym: "vitamin B5 catabolic process" EXACT []
synonym: "vitamin B5 catabolism" EXACT []
is_a: GO:0009109 ! coenzyme catabolic process
is_a: GO:0015939 ! pantothenate metabolic process
is_a: GO:0042219 ! cellular modified amino acid catabolic process
is_a: GO:0042365 ! water-soluble vitamin catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0015942
name: formate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving formate, also known as methanoate, the anion HCOO- derived from methanoic (formic) acid." [ISBN:0198506732]
subset: gosubset_prok
synonym: "formate metabolism" EXACT []
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0015943
name: formate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of formate, also known as methanoate, the anion HCOO- derived from methanoic (formic) acid." [ISBN:0198506732]
subset: gosubset_prok
synonym: "formate anabolism" EXACT []
synonym: "formate biosynthesis" EXACT []
synonym: "formate formation" EXACT []
synonym: "formate synthesis" EXACT []
synonym: "formic acid biosynthesis" EXACT []
synonym: "formic acid biosynthetic process" EXACT []
is_a: GO:0015942 ! formate metabolic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process

[Term]
id: GO:0015944
name: formate oxidation
namespace: biological_process
def: "The chemical reactions and pathways by which formate is converted to CO2." [MetaCyc:PWY-1881]
subset: gosubset_prok
synonym: "formic acid oxidation" EXACT []
xref: MetaCyc:PWY-1881
is_a: GO:0015942 ! formate metabolic process
is_a: GO:0055114 ! oxidation-reduction process

[Term]
id: GO:0015945
name: methanol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving methanol, CH3-OH, a colorless, flammable, mobile, poisonous liquid, widely used as a solvent." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "methanol metabolism" EXACT []
is_a: GO:0034308 ! primary alcohol metabolic process

[Term]
id: GO:0015946
name: methanol oxidation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the conversion of methanol to methyl-Coenzyme M." [MetaCyc:CO2FORM-PWY]
subset: gosubset_prok
xref: MetaCyc:CO2FORM-PWY
is_a: GO:0015945 ! methanol metabolic process
is_a: GO:0055114 ! oxidation-reduction process

[Term]
id: GO:0015947
name: methane metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving methane, a colorless, odorless, flammable gas with the formula CH4. It is the simplest of the alkanes." [ISBN:0198506732]
subset: gosubset_prok
synonym: "methane metabolism" EXACT []
is_a: GO:0043446 ! cellular alkane metabolic process

[Term]
id: GO:0015948
name: methanogenesis
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of methane, a colorless, odorless, flammable gas with the formula CH4. It is the simplest of the alkanes." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "methane biosynthesis" EXACT []
synonym: "methane biosynthetic process" EXACT []
xref: UM-BBD_pathwayID:meth
xref: Wikipedia:Methanogenesis
is_a: GO:0009061 ! anaerobic respiration
is_a: GO:0015947 ! methane metabolic process
is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds
is_a: GO:0043447 ! alkane biosynthetic process

[Term]
id: GO:0015949
name: nucleobase-containing small molecule interconversion
namespace: biological_process
def: "The chemical reactions and pathways by which a nucleobase, nucleoside or nucleotide small molecule is synthesized from another nucleobase, nucleoside or nucleotide small molecule." [GOC:mah, ISBN:0306444747, ISBN:0471394831]
subset: goslim_pir
subset: gosubset_prok
xref: MetaCyc:P1-PWY
xref: Reactome:REACT_102506 "Synthesis and interconversion of nucleotide di- and triphosphates, Oryza sativa"
xref: Reactome:REACT_107209 "Synthesis and interconversion of nucleotide di- and triphosphates, Drosophila melanogaster"
xref: Reactome:REACT_108426 "Synthesis and interconversion of nucleotide di- and triphosphates, Danio rerio"
xref: Reactome:REACT_109014 "Synthesis and interconversion of nucleotide di- and triphosphates, Saccharomyces cerevisiae"
xref: Reactome:REACT_109980 "Synthesis and interconversion of nucleotide di- and triphosphates, Gallus gallus"
xref: Reactome:REACT_110584 "Synthesis and interconversion of nucleotide di- and triphosphates, Escherichia coli"
xref: Reactome:REACT_21330 "Synthesis and interconversion of nucleotide di- and triphosphates, Homo sapiens"
xref: Reactome:REACT_29794 "Synthesis and interconversion of nucleotide di- and triphosphates, Caenorhabditis elegans"
xref: Reactome:REACT_41788 "Synthesis and interconversion of nucleotide di- and triphosphates, Canis familiaris"
xref: Reactome:REACT_77249 "Synthesis and interconversion of nucleotide di- and triphosphates, Arabidopsis thaliana"
xref: Reactome:REACT_77992 "Synthesis and interconversion of nucleotide di- and triphosphates, Xenopus tropicalis"
xref: Reactome:REACT_80972 "Synthesis and interconversion of nucleotide di- and triphosphates, Taeniopygia guttata"
xref: Reactome:REACT_82335 "Synthesis and interconversion of nucleotide di- and triphosphates, Mus musculus"
xref: Reactome:REACT_82859 "Synthesis and interconversion of nucleotide di- and triphosphates, Bos taurus"
xref: Reactome:REACT_86356 "Synthesis and interconversion of nucleotide di- and triphosphates, Schizosaccharomyces pombe"
xref: Reactome:REACT_89651 "Synthesis and interconversion of nucleotide di- and triphosphates, Mycobacterium tuberculosis"
xref: Reactome:REACT_90295 "Synthesis and interconversion of nucleotide di- and triphosphates, Plasmodium falciparum"
xref: Reactome:REACT_95252 "Synthesis and interconversion of nucleotide di- and triphosphates, Rattus norvegicus"
xref: Reactome:REACT_96776 "Synthesis and interconversion of nucleotide di- and triphosphates, Sus scrofa"
xref: Reactome:REACT_97285 "Synthesis and interconversion of nucleotide di- and triphosphates, Dictyostelium discoideum"
is_a: GO:0055086 ! nucleobase-containing small molecule metabolic process

[Term]
id: GO:0015950
name: purine nucleotide interconversion
namespace: biological_process
def: "The chemical reactions and pathways by which a purine nucleotide is synthesized from another purine nucleotide." [GOC:mah, ISBN:0306444747, ISBN:0471394831]
subset: gosubset_prok
is_a: GO:0006163 ! purine nucleotide metabolic process
is_a: GO:0015949 ! nucleobase-containing small molecule interconversion

[Term]
id: GO:0015951
name: purine ribonucleotide interconversion
namespace: biological_process
def: "The chemical reactions and pathways by which a purine ribonucleotide is synthesized from another purine ribonucleotide." [GOC:mah, ISBN:0306444747, ISBN:0471394831]
subset: gosubset_prok
is_a: GO:0009150 ! purine ribonucleotide metabolic process
is_a: GO:0015950 ! purine nucleotide interconversion

[Term]
id: GO:0015952
name: purine deoxyribonucleotide interconversion
namespace: biological_process
def: "The chemical reactions and pathways by which a purine deoxyribonucleotide is synthesized from another purine deoxyribonucleotide." [GOC:mah, ISBN:0306444747, ISBN:0471394831]
subset: gosubset_prok
is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process
is_a: GO:0015950 ! purine nucleotide interconversion

[Term]
id: GO:0015953
name: pyrimidine nucleotide interconversion
namespace: biological_process
def: "The chemical reactions and pathways by which a pyrimidine nucleotide is synthesized from another pyrimidine nucleotide." [GOC:mah, ISBN:0306444747, ISBN:0471394831]
subset: gosubset_prok
is_a: GO:0006220 ! pyrimidine nucleotide metabolic process
is_a: GO:0015949 ! nucleobase-containing small molecule interconversion

[Term]
id: GO:0015954
name: pyrimidine ribonucleotide interconversion
namespace: biological_process
def: "The chemical reactions and pathways by which a pyrimidine ribonucleotide is synthesized from another pyrimidine ribonucleotide." [GOC:mah, ISBN:0306444747, ISBN:0471394831]
subset: gosubset_prok
is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process
is_a: GO:0015953 ! pyrimidine nucleotide interconversion

[Term]
id: GO:0015955
name: pyrimidine deoxyribonucleotide interconversion
namespace: biological_process
def: "The chemical reactions and pathways by which a pyrimidine deoxyribonucleotide is synthesized from another pyrimidine deoxyribonucleotide." [GOC:mah, ISBN:0306444747, ISBN:0471394831]
subset: gosubset_prok
is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process
is_a: GO:0015953 ! pyrimidine nucleotide interconversion

[Term]
id: GO:0015956
name: bis(5'-nucleosidyl) oligophosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a bis(5'-nucleosidyl) oligophosphate, a compound formed of two nucleosides joined together through their 5' carbons by a chain of phosphate molecules." [GOC:mah, PMID:10970777]
subset: gosubset_prok
synonym: "bis(5'-nucleosidyl) oligophosphate metabolism" EXACT []
is_a: GO:0009117 ! nucleotide metabolic process

[Term]
id: GO:0015957
name: bis(5'-nucleosidyl) oligophosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a bis(5'-nucleosidyl) oligophosphate, a compound formed of two nucleosides joined together through their 5' carbons by a chain of phosphate molecules." [GOC:mah, PMID:10970777]
subset: gosubset_prok
synonym: "bis(5'-nucleosidyl) oligophosphate anabolism" EXACT []
synonym: "bis(5'-nucleosidyl) oligophosphate biosynthesis" EXACT []
synonym: "bis(5'-nucleosidyl) oligophosphate formation" EXACT []
synonym: "bis(5'-nucleosidyl) oligophosphate synthesis" EXACT []
is_a: GO:0009165 ! nucleotide biosynthetic process
is_a: GO:0015956 ! bis(5'-nucleosidyl) oligophosphate metabolic process

[Term]
id: GO:0015958
name: bis(5'-nucleosidyl) oligophosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a bis(5'-nucleosidyl) oligophosphate, a compound formed of two nucleosides joined together through their 5' carbons by a chain of phosphate molecules." [GOC:mah, PMID:10970777]
subset: gosubset_prok
synonym: "bis(5'-nucleosidyl) oligophosphate breakdown" EXACT []
synonym: "bis(5'-nucleosidyl) oligophosphate catabolism" EXACT []
synonym: "bis(5'-nucleosidyl) oligophosphate degradation" EXACT []
is_a: GO:0009166 ! nucleotide catabolic process
is_a: GO:0015956 ! bis(5'-nucleosidyl) oligophosphate metabolic process

[Term]
id: GO:0015959
name: diadenosine polyphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving diadenosine polyphosphate, a derivative of the nucleoside adenosine with phosphate groups attached." [GOC:ai]
subset: gosubset_prok
synonym: "diadenosine polyphosphate metabolism" EXACT []
is_a: GO:0009117 ! nucleotide metabolic process

[Term]
id: GO:0015960
name: diadenosine polyphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of diadenosine polyphosphate, a derivative of the nucleoside adenosine with phosphate groups attached." [GOC:ai]
subset: gosubset_prok
synonym: "diadenosine polyphosphate anabolism" EXACT []
synonym: "diadenosine polyphosphate biosynthesis" EXACT []
synonym: "diadenosine polyphosphate formation" EXACT []
synonym: "diadenosine polyphosphate synthesis" EXACT []
is_a: GO:0009165 ! nucleotide biosynthetic process
is_a: GO:0015959 ! diadenosine polyphosphate metabolic process

[Term]
id: GO:0015961
name: diadenosine polyphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of diadenosine polyphosphate, a derivative of the nucleoside adenosine with phosphate groups attached." [GOC:ai]
subset: gosubset_prok
synonym: "diadenosine polyphosphate breakdown" EXACT []
synonym: "diadenosine polyphosphate catabolism" EXACT []
synonym: "diadenosine polyphosphate degradation" EXACT []
is_a: GO:0009166 ! nucleotide catabolic process
is_a: GO:0015959 ! diadenosine polyphosphate metabolic process

[Term]
id: GO:0015962
name: diadenosine triphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving diadenosine triphosphate, a derivative of the nucleoside adenosine with three phosphate groups attached." [GOC:ai]
subset: gosubset_prok
synonym: "diadenosine triphosphate metabolism" EXACT []
is_a: GO:0015959 ! diadenosine polyphosphate metabolic process

[Term]
id: GO:0015963
name: diadenosine triphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of diadenosine triphosphate, a derivative of the nucleoside adenosine with three phosphate groups attached." [GOC:ai]
subset: gosubset_prok
synonym: "diadenosine triphosphate anabolism" EXACT []
synonym: "diadenosine triphosphate biosynthesis" EXACT []
synonym: "diadenosine triphosphate formation" EXACT []
synonym: "diadenosine triphosphate synthesis" EXACT []
is_a: GO:0015960 ! diadenosine polyphosphate biosynthetic process
is_a: GO:0015962 ! diadenosine triphosphate metabolic process

[Term]
id: GO:0015964
name: diadenosine triphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of diadenosine triphosphate, a derivative of the nucleoside adenosine with three phosphate groups attached." [GOC:ai]
subset: gosubset_prok
synonym: "diadenosine triphosphate breakdown" EXACT []
synonym: "diadenosine triphosphate catabolism" EXACT []
synonym: "diadenosine triphosphate degradation" EXACT []
is_a: GO:0015961 ! diadenosine polyphosphate catabolic process
is_a: GO:0015962 ! diadenosine triphosphate metabolic process

[Term]
id: GO:0015965
name: diadenosine tetraphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving diadenosine tetraphosphate, a derivative of the nucleoside adenosine with four phosphate groups attached." [GOC:ai]
subset: gosubset_prok
synonym: "diadenosine tetraphosphate metabolism" EXACT []
is_a: GO:0015959 ! diadenosine polyphosphate metabolic process

[Term]
id: GO:0015966
name: diadenosine tetraphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of diadenosine tetraphosphate, a derivative of the nucleoside adenosine with four phosphate groups attached." [GOC:ai]
subset: gosubset_prok
synonym: "diadenosine tetraphosphate anabolism" EXACT []
synonym: "diadenosine tetraphosphate biosynthesis" EXACT []
synonym: "diadenosine tetraphosphate formation" EXACT []
synonym: "diadenosine tetraphosphate synthesis" EXACT []
is_a: GO:0015960 ! diadenosine polyphosphate biosynthetic process
is_a: GO:0015965 ! diadenosine tetraphosphate metabolic process

[Term]
id: GO:0015967
name: diadenosine tetraphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of diadenosine tetraphosphate, a derivative of the nucleoside adenosine with four phosphate groups attached." [GOC:ai]
subset: gosubset_prok
synonym: "diadenosine tetraphosphate breakdown" EXACT []
synonym: "diadenosine tetraphosphate catabolism" EXACT []
synonym: "diadenosine tetraphosphate degradation" EXACT []
is_a: GO:0015961 ! diadenosine polyphosphate catabolic process
is_a: GO:0015965 ! diadenosine tetraphosphate metabolic process

[Term]
id: GO:0015968
name: stringent response
namespace: biological_process
def: "A specific global change in the metabolism of a bacterial cell (the downregulation of nucleic acid and protein synthesis, and the simultaneous upregulation of protein degradation and amino acid synthesis) as a result of starvation." [GOC:jl, ISBN:0124325653, PMID:11282471]
subset: gosubset_prok
xref: Wikipedia:Stringent_response
is_a: GO:0009267 ! cellular response to starvation

[Term]
id: GO:0015969
name: guanosine tetraphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates." [GOC:ai]
subset: gosubset_prok
synonym: "guanosine tetraphosphate (5'-ppGpp-3') metabolic process" EXACT []
synonym: "guanosine tetraphosphate (5'-ppGpp-3') metabolism" EXACT []
synonym: "guanosine tetraphosphate metabolism" EXACT []
xref: MetaCyc:PPGPPMET-PWY
is_a: GO:0009150 ! purine ribonucleotide metabolic process
is_a: GO:0034035 ! purine ribonucleoside bisphosphate metabolic process
is_a: GO:1901068 ! guanosine-containing compound metabolic process

[Term]
id: GO:0015970
name: guanosine tetraphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates." [GOC:ai]
subset: gosubset_prok
synonym: "guanosine tetraphosphate (5'-ppGpp-3') biosynthesis" EXACT []
synonym: "guanosine tetraphosphate (5'-ppGpp-3') biosynthetic process" EXACT []
synonym: "guanosine tetraphosphate anabolism" EXACT []
synonym: "guanosine tetraphosphate biosynthesis" EXACT []
synonym: "guanosine tetraphosphate formation" EXACT []
synonym: "guanosine tetraphosphate synthesis" EXACT []
is_a: GO:0009152 ! purine ribonucleotide biosynthetic process
is_a: GO:0015969 ! guanosine tetraphosphate metabolic process
is_a: GO:0034036 ! purine ribonucleoside bisphosphate biosynthetic process
is_a: GO:1901070 ! guanosine-containing compound biosynthetic process

[Term]
id: GO:0015971
name: guanosine tetraphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates." [GOC:ai]
subset: gosubset_prok
synonym: "guanosine tetraphosphate (5'-ppGpp-3') catabolic process" EXACT []
synonym: "guanosine tetraphosphate (5'-ppGpp-3') catabolism" EXACT []
synonym: "guanosine tetraphosphate breakdown" EXACT []
synonym: "guanosine tetraphosphate catabolism" EXACT []
synonym: "guanosine tetraphosphate degradation" EXACT []
is_a: GO:0009154 ! purine ribonucleotide catabolic process
is_a: GO:0015969 ! guanosine tetraphosphate metabolic process
is_a: GO:0034037 ! purine ribonucleoside bisphosphate catabolic process
is_a: GO:1901069 ! guanosine-containing compound catabolic process

[Term]
id: GO:0015972
name: guanosine pentaphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving guanine pentaphosphate (5'-pppGpp-3'), a derivative of guanine riboside with five phosphates." [GOC:ai]
subset: gosubset_prok
synonym: "guanosine pentaphosphate (5'-pppGpp-3') metabolic process" EXACT []
synonym: "guanosine pentaphosphate (5'-pppGpp-3') metabolism" EXACT []
synonym: "guanosine pentaphosphate metabolism" EXACT []
is_a: GO:0009150 ! purine ribonucleotide metabolic process
is_a: GO:0034035 ! purine ribonucleoside bisphosphate metabolic process
is_a: GO:1901068 ! guanosine-containing compound metabolic process

[Term]
id: GO:0015973
name: guanosine pentaphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of guanine pentaphosphate (5'-pppGpp-3'), a derivative of guanine riboside with five phosphates." [GOC:ai]
subset: gosubset_prok
synonym: "guanosine pentaphosphate (5'-pppGpp-3') biosynthesis" EXACT []
synonym: "guanosine pentaphosphate (5'-pppGpp-3') biosynthetic process" EXACT []
synonym: "guanosine pentaphosphate anabolism" EXACT []
synonym: "guanosine pentaphosphate biosynthesis" EXACT []
synonym: "guanosine pentaphosphate formation" EXACT []
synonym: "guanosine pentaphosphate synthesis" EXACT []
is_a: GO:0009152 ! purine ribonucleotide biosynthetic process
is_a: GO:0015972 ! guanosine pentaphosphate metabolic process
is_a: GO:0034036 ! purine ribonucleoside bisphosphate biosynthetic process
is_a: GO:1901070 ! guanosine-containing compound biosynthetic process

[Term]
id: GO:0015974
name: guanosine pentaphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of guanine pentaphosphate (5'-pppGpp-3'), a derivative of guanine riboside with five phosphates." [GOC:ai]
subset: gosubset_prok
synonym: "guanosine pentaphosphate (5'-pppGpp-3') catabolic process" EXACT []
synonym: "guanosine pentaphosphate (5'-pppGpp-3') catabolism" EXACT []
synonym: "guanosine pentaphosphate breakdown" EXACT []
synonym: "guanosine pentaphosphate catabolism" EXACT []
synonym: "guanosine pentaphosphate degradation" EXACT []
is_a: GO:0009154 ! purine ribonucleotide catabolic process
is_a: GO:0015972 ! guanosine pentaphosphate metabolic process
is_a: GO:0034037 ! purine ribonucleoside bisphosphate catabolic process
is_a: GO:1901069 ! guanosine-containing compound catabolic process

[Term]
id: GO:0015975
name: energy derivation by oxidation of reduced inorganic compounds
namespace: biological_process
def: "The chemical reactions and pathways by which a cell derives energy from inorganic compounds; results in the oxidation of the compounds from which energy is released." [GOC:mah]
subset: gosubset_prok
synonym: "chemolithotrophie" EXACT []
synonym: "chemolithotrophy" EXACT []
synonym: "lithotrophy" EXACT [Wikipedia:Lithotrophy]
xref: Wikipedia:Lithotrophy
is_a: GO:0006091 ! generation of precursor metabolites and energy
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0055114 ! oxidation-reduction process

[Term]
id: GO:0015976
name: carbon utilization
namespace: biological_process
alt_id: GO:0015978
def: "A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbon sources and then activates genes to scavenge the last traces of the primary carbon source and to transport and metabolize alternative carbon sources such as carbon dioxide or carbonic acid. The utilization process begins when the cell or organism detects carbon levels, includes the activation of genes whose products detect, transport or metabolize carbon-containing substances, and ends when carbon is incorporated into the cell or organism's metabolism." [GOC:mah, GOC:mlg]
subset: goslim_chembl
subset: goslim_pir
subset: gosubset_prok
synonym: "carbon utilization by utilization of organic compounds" EXACT [GOC:mah]
synonym: "heterotrophy" EXACT []
xref: Wikipedia:Heterotroph
is_a: GO:0044699 ! single-organism process
relationship: has_part GO:0071702 ! organic substance transport
relationship: has_part GO:0071703 ! detection of organic substance
relationship: has_part GO:0071704 ! organic substance metabolic process

[Term]
id: GO:0015977
name: carbon fixation
namespace: biological_process
def: "A metabolic process in which carbon (usually derived from carbon dioxide) is incorporated into organic compounds (usually carbohydrates)." [GOC:jl, GOC:mah]
subset: gosubset_prok
synonym: "autotrophic CO2 fixation" EXACT []
synonym: "autotrophic CO2 fixation pathway" EXACT []
synonym: "autotrophy" EXACT []
synonym: "carbon dioxide fixation" NARROW []
xref: Wikipedia:Carbon_fixation
is_a: GO:0044710 ! single-organism metabolic process
is_a: GO:0071704 ! organic substance metabolic process

[Term]
id: GO:0015979
name: photosynthesis
namespace: biological_process
def: "The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds." [ISBN:0198547684]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
xref: Wikipedia:Photosynthesis
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0015980
name: energy derivation by oxidation of organic compounds
namespace: biological_process
def: "The chemical reactions and pathways by which a cell derives energy from organic compounds; results in the oxidation of the compounds from which energy is released." [GOC:mah]
subset: gosubset_prok
synonym: "chemoorganotrophy" EXACT []
is_a: GO:0006091 ! generation of precursor metabolites and energy
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0055114 ! oxidation-reduction process

[Term]
id: GO:0015981
name: obsolete passive proton transport, down the electrochemical gradient
namespace: biological_process
def: "OBSOLETE. The passive movement of protons from areas of high proton concentration and electrical potential to areas where concentration and electrical potential are low." [ISBN:0716731363]
comment: This term was made obsolete because it represents a passive process which occurs without the aid of gene products.
synonym: "passive proton transport, down the electrochemical gradient" EXACT []
is_obsolete: true
consider: GO:0015992

[Term]
id: GO:0015982
name: obsolete antiport
namespace: biological_process
def: "OBSOLETE. The process of coupled solute translocation in which two solutes equilibrate across an osmotic barrier, the translocation of solute being coupled to the translocation of the other in the opposite direction." [ISBN:0198506732]
comment: This term was made obsolete because it represents a molecular function rather than a biological process.
synonym: "antiport" EXACT []
is_obsolete: true
replaced_by: GO:0015297

[Term]
id: GO:0015983
name: obsolete symport
namespace: biological_process
def: "OBSOLETE. The process of solute translocation in which two solutes equilibrate across an osmotic barrier, and the translocation of one solute is coupled to the translocation of the other in the same direction." [ISBN:0198506732]
comment: This term was made obsolete because it represents a molecular function rather than a biological process.
synonym: "symport" EXACT []
is_obsolete: true
replaced_by: GO:0015293

[Term]
id: GO:0015984
name: obsolete uniport
namespace: biological_process
def: "OBSOLETE. The process of noncoupled solute translocation or facilitated diffusion." [ISBN:0198506732]
comment: This term was made obsolete because it represents a molecular function rather than a biological process.
synonym: "uniport" EXACT []
is_obsolete: true
replaced_by: GO:0015292

[Term]
id: GO:0015985
name: energy coupled proton transport, down electrochemical gradient
namespace: biological_process
def: "The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that provides energy for the synthesis of ATP or GTP." [GOC:mah]
subset: gosubset_prok
is_a: GO:1902600 ! hydrogen ion transmembrane transport

[Term]
id: GO:0015986
name: ATP synthesis coupled proton transport
namespace: biological_process
def: "The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [ISBN:0716731363]
subset: gosubset_prok
synonym: "chemiosmosis" BROAD [GOC:rs]
is_a: GO:0006754 ! ATP biosynthetic process
is_a: GO:0015985 ! energy coupled proton transport, down electrochemical gradient

[Term]
id: GO:0015987
name: GTP synthesis coupled proton transport
namespace: biological_process
def: "The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers GTP synthesis." [ISBN:0716731363]
is_a: GO:0015985 ! energy coupled proton transport, down electrochemical gradient

[Term]
id: GO:0015988
name: energy coupled proton transmembrane transport, against electrochemical gradient
namespace: biological_process
def: "The transport of protons across a membrane and against an electrochemical gradient, using energy from a source such as ATP hydrolysis, light, or electron transport." [GOC:mah]
subset: gosubset_prok
is_a: GO:1902600 ! hydrogen ion transmembrane transport

[Term]
id: GO:0015989
name: light-driven proton transport
namespace: biological_process
def: "The transport of protons against an electrochemical gradient, using energy from light." [GOC:mah]
is_a: GO:0015988 ! energy coupled proton transmembrane transport, against electrochemical gradient

[Term]
id: GO:0015990
name: electron transport coupled proton transport
namespace: biological_process
def: "The transport of protons against an electrochemical gradient, using energy from electron transport." [GOC:mah]
is_a: GO:0015988 ! energy coupled proton transmembrane transport, against electrochemical gradient

[Term]
id: GO:0015991
name: ATP hydrolysis coupled proton transport
namespace: biological_process
def: "The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw]
subset: gosubset_prok
is_a: GO:0015988 ! energy coupled proton transmembrane transport, against electrochemical gradient
is_a: GO:0090662 ! ATP hydrolysis coupled transmembrane transport

[Term]
id: GO:0015992
name: proton transport
namespace: biological_process
def: "The directed movement of protons (hydrogen ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]
subset: gosubset_prok
synonym: "hydrogen ion transport" EXACT []
synonym: "passive proton transport, down the electrochemical gradient" NARROW []
xref: Reactome:REACT_100717 "The proton buffering model, Gallus gallus"
xref: Reactome:REACT_102006 "Mitochondrial Uncoupling Proteins, Xenopus tropicalis"
xref: Reactome:REACT_103123 "Mitochondrial Uncoupling Proteins, Mus musculus"
xref: Reactome:REACT_104490 "Mitochondrial Uncoupling Proteins, Arabidopsis thaliana"
xref: Reactome:REACT_105995 "Mitochondrial Uncoupling Proteins, Gallus gallus"
xref: Reactome:REACT_106176 "Mitochondrial Uncoupling Proteins, Canis familiaris"
xref: Reactome:REACT_106794 "The proton buffering model, Arabidopsis thaliana"
xref: Reactome:REACT_110839 "Mitochondrial Uncoupling Proteins, Bos taurus"
xref: Reactome:REACT_29555 "The proton buffering model, Canis familiaris"
xref: Reactome:REACT_30770 "Mitochondrial Uncoupling Proteins, Taeniopygia guttata"
xref: Reactome:REACT_31883 "The proton buffering model, Xenopus tropicalis"
xref: Reactome:REACT_6196 "The proton buffering model, Homo sapiens"
xref: Reactome:REACT_6341 "Mitochondrial Uncoupling Proteins, Homo sapiens"
xref: Reactome:REACT_77530 "Mitochondrial Uncoupling Proteins, Oryza sativa"
xref: Reactome:REACT_80235 "The proton buffering model, Oryza sativa"
xref: Reactome:REACT_82088 "The proton buffering model, Sus scrofa"
xref: Reactome:REACT_83467 "Mitochondrial Uncoupling Proteins, Sus scrofa"
xref: Reactome:REACT_88310 "The proton buffering model, Rattus norvegicus"
xref: Reactome:REACT_89771 "The proton buffering model, Taeniopygia guttata"
xref: Reactome:REACT_90272 "The proton buffering model, Danio rerio"
xref: Reactome:REACT_92912 "Mitochondrial Uncoupling Proteins, Danio rerio"
xref: Reactome:REACT_92975 "The proton buffering model, Bos taurus"
xref: Reactome:REACT_94505 "Mitochondrial Uncoupling Proteins, Rattus norvegicus"
xref: Reactome:REACT_95151 "The proton buffering model, Mus musculus"
is_a: GO:0006818 ! hydrogen transport
is_a: GO:0015672 ! monovalent inorganic cation transport

[Term]
id: GO:0015993
name: molecular hydrogen transport
namespace: biological_process
def: "The directed movement of molecular hydrogen (H2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]
is_a: GO:0006818 ! hydrogen transport

[Term]
id: GO:0015994
name: chlorophyll metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment." [GOC:jl]
subset: gosubset_prok
synonym: "chlorophyll metabolism" EXACT []
is_a: GO:0006778 ! porphyrin-containing compound metabolic process

[Term]
id: GO:0015995
name: chlorophyll biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors." [GOC:jl]
subset: gosubset_prok
synonym: "chlorophyll anabolism" EXACT []
synonym: "chlorophyll biosynthesis" EXACT []
synonym: "chlorophyll formation" EXACT []
synonym: "chlorophyll synthesis" EXACT []
xref: MetaCyc:CHLOROPHYLL-SYN
is_a: GO:0006779 ! porphyrin-containing compound biosynthetic process
is_a: GO:0015994 ! chlorophyll metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0046148 ! pigment biosynthetic process

[Term]
id: GO:0015996
name: chlorophyll catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, into less complex products." [GOC:jl]
subset: gosubset_prok
synonym: "chlorophyll breakdown" EXACT []
synonym: "chlorophyll catabolism" EXACT []
synonym: "chlorophyll degradation" EXACT []
is_a: GO:0006787 ! porphyrin-containing compound catabolic process
is_a: GO:0015994 ! chlorophyll metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0046149 ! pigment catabolic process

[Term]
id: GO:0015997
name: obsolete ubiquinone biosynthetic process monooxygenase activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it incorporates biological process information.
synonym: "coenzyme Q biosynthesis monooxygenase activity" EXACT []
synonym: "coenzyme Q biosynthetic process monooxygenase activity" EXACT []
synonym: "ubiquinone anabolism monooxygenase activity" EXACT []
synonym: "ubiquinone biosynthetic process monooxygenase activity" EXACT []
synonym: "ubiquinone formation monooxygenase activity" EXACT []
synonym: "ubiquinone synthesis monooxygenase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0016002
name: sulfite reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrogen sulfide + acceptor + 3 H2O = sulfite + reduced acceptor." [EC:1.8.99.1]
subset: gosubset_prok
synonym: "assimilatory sulfite reductase activity" EXACT [EC:1.8.99.1]
synonym: "assimilatory-type sulfite reductase activity" EXACT [EC:1.8.99.1]
synonym: "hydrogen-sulfide:(acceptor) oxidoreductase activity" EXACT [EC:1.8.99.1]
synonym: "hydrogen-sulfide:acceptor oxidoreductase activity" EXACT [EC:1.8.99.1]
synonym: "siroheme sulfite reductase activity" NARROW [MetaCyc:SULFITE-REDUCTASE-RXN]
synonym: "sulphite reductase activity" EXACT []
xref: EC:1.8.99.1
xref: MetaCyc:SULFITE-REDUCTASE-RXN
xref: RHEA:10547
is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors

[Term]
id: GO:0016004
name: phospholipase activator activity
namespace: molecular_function
def: "Increases the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a glycerophospholipid." [GOC:ai]
is_a: GO:0060229 ! lipase activator activity
relationship: positively_regulates GO:0004620 ! phospholipase activity

[Term]
id: GO:0016005
name: phospholipase A2 activator activity
namespace: molecular_function
def: "Increases the activity of the enzyme phospholipase A2." [GOC:ai]
is_a: GO:0016004 ! phospholipase activator activity
relationship: positively_regulates GO:0004623 ! phospholipase A2 activity

[Term]
id: GO:0016006
name: Nebenkern
namespace: cellular_component
def: "A product of the fusion of the mitochondria during spermatogenesis. After the completion of meiosis the mitochondria of the spermatid collect along side the nucleus and fuse into two masses; these wrap around each other to produce the spherical Nebenkern. During flagellum elongation the Nebenkern unfolds and the two derivatives (major and minor mitochondrial derivatives) elongate down the axoneme." [GOC:ma]
is_a: GO:0005739 ! mitochondrion

[Term]
id: GO:0016007
name: mitochondrial derivative
namespace: cellular_component
def: "The major and minor mitochondrial derivatives are the mitochondria of the sperm tail and derive by the unfolding of the Nebenkern during flagellum elongation." [GOC:ma]
is_a: GO:0005739 ! mitochondrion

[Term]
id: GO:0016008
name: major mitochondrial derivative
namespace: cellular_component
def: "The larger of the two mitochondrial derivatives that arise by the unfolding of the Nebenkern during flagellum elongation; the major mitochondrial derivative is ovoid and darker than the minor derivative." [GOC:mah, PMID:17123504]
is_a: GO:0016007 ! mitochondrial derivative

[Term]
id: GO:0016009
name: minor mitochondrial derivative
namespace: cellular_component
def: "The smaller of the two mitochondrial derivatives that arise by the unfolding of the Nebenkern during flagellum elongation." [GOC:mah, PMID:17123504]
is_a: GO:0016007 ! mitochondrial derivative

[Term]
id: GO:0016010
name: dystrophin-associated glycoprotein complex
namespace: cellular_component
def: "A multiprotein complex that forms a strong mechanical link between the cytoskeleton and extracellular matrix; typical of, but not confined to, muscle cells. The complex is composed of transmembrane, cytoplasmic, and extracellular proteins, including dystrophin, sarcoglycans, dystroglycan, dystrobrevins, syntrophins, sarcospan, caveolin-3, and NO synthase." [PMID:15117830, PMID:16710609]
subset: goslim_pir
synonym: "DGC" EXACT []
synonym: "dystrophin glycoprotein complex" EXACT []
is_a: GO:0090665 ! glycoprotein complex
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0016011
name: dystroglycan complex
namespace: cellular_component
def: "A protein complex that includes alpha- and beta-dystroglycan, which are alternative products of the same gene; the laminin-binding component of the dystrophin-associated glycoprotein complex, providing a link between the subsarcolemmal cytoskeleton (in muscle cells) and the extracellular matrix. Alpha-dystroglycan is an extracellular protein binding to alpha-laminin and to beta-dystroglycan; beta-dystroglycan is a transmembrane protein which binds alpha-dystroglycan and dystrophin." [PMID:15117830, PMID:16710609]
is_a: GO:0098797 ! plasma membrane protein complex
relationship: part_of GO:0016010 ! dystrophin-associated glycoprotein complex

[Term]
id: GO:0016012
name: sarcoglycan complex
namespace: cellular_component
def: "A protein complex formed of four sarcoglycans plus sarcospan; there are six known sarcoglycans: alpha-, beta-, gamma-, delta-, epsilon- and zeta-sarcoglycan; all are N-glycosylated single-pass transmembrane proteins. The sarcoglycan-sarcospan complex is a subcomplex of the dystrophin glycoprotein complex, and is fixed to the dystrophin axis by a lateral association with the dystroglycan complex." [PMID:15117830, PMID:16710609]
synonym: "sarcoglycan-sarcospan complex" EXACT []
is_a: GO:0098797 ! plasma membrane protein complex
relationship: part_of GO:0016011 ! dystroglycan complex

[Term]
id: GO:0016013
name: syntrophin complex
namespace: cellular_component
def: "A protein complex that includes alpha-, beta1-, beta2-syntrophins and syntrophin-like proteins; the syntrophin complex binds to the second half of the carboxy-terminal domain of dystrophin; also associates with neuronal nitric oxide synthase." [http://www.dmd.nl/DGC.html#syn]
synonym: "nitric oxide synthase-dystrophin complex, skeletal muscle" RELATED [CORUM:416]
is_a: GO:0098797 ! plasma membrane protein complex
relationship: part_of GO:0016010 ! dystrophin-associated glycoprotein complex

[Term]
id: GO:0016014
name: dystrobrevin complex
namespace: cellular_component
def: "A protein complex comprising alpha- and beta-dystrobrevin; forms part of the dystrophin glycoprotein complex." [PMID:15117830, PMID:16710609]
is_a: GO:0098797 ! plasma membrane protein complex
relationship: part_of GO:0016010 ! dystrophin-associated glycoprotein complex

[Term]
id: GO:0016015
name: morphogen activity
namespace: molecular_function
def: "Acts as a trigger for a pattern specification process when present at a specific concentration within a gradient." [GOC:go_curators]
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0016016
name: obsolete short-wave-sensitive opsin
namespace: molecular_function
def: "OBSOLETE. An opsin with maximal absorption between 400 and 500 nm." [PMID:10594055]
comment: This term was made obsolete because it refers to a class of proteins.
synonym: "short-wave-sensitive opsin" EXACT []
is_obsolete: true
consider: GO:0007603
consider: GO:0009588
consider: GO:0009881
consider: GO:0016021
consider: GO:0016918
consider: GO:0046876

[Term]
id: GO:0016018
name: cyclosporin A binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with cyclosporin A, a cyclic undecapeptide that contains several N-methylated and unusual amino acids." [GOC:mb]
synonym: "cyclophilin" RELATED []
is_a: GO:0008144 ! drug binding
is_a: GO:0042277 ! peptide binding

[Term]
id: GO:0016019
name: peptidoglycan receptor activity
namespace: molecular_function
def: "Combining with a peptidoglycan and transmitting the signal to initiate a change in cell activity." [PMID:14698226]
comment: Note that only peptidoglycan recognition proteins with receptor activity should be annotated to this term; otherwise use 'peptidoglycan binding ; GO:0042834' instead.
synonym: "peptidoglycan recognition activity" NARROW []
is_a: GO:0008329 ! signaling pattern recognition receptor activity
relationship: has_part GO:0042834 ! peptidoglycan binding

[Term]
id: GO:0016020
name: membrane
namespace: cellular_component
def: "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
xref: Wikipedia:Biological_membrane
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0016021
name: integral component of membrane
namespace: cellular_component
def: "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
subset: goslim_chembl
subset: gosubset_prok
synonym: "integral to membrane" NARROW []
synonym: "transmembrane" RELATED [GOC:mah]
xref: Wikipedia:Transmembrane_protein
is_a: GO:0031224 ! intrinsic component of membrane

[Term]
id: GO:0016023
name: cytoplasmic, membrane-bounded vesicle
namespace: cellular_component
def: "A membrane-bounded vesicle found in the cytoplasm of the cell." [GOC:ai, GOC:mah]
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_yeast
subset: gosubset_prok
synonym: "cytoplasmic membrane bounded vesicle" EXACT []
synonym: "cytoplasmic membrane-enclosed vesicle" EXACT []
is_a: GO:0031410 ! cytoplasmic vesicle
is_a: GO:0031988 ! membrane-bounded vesicle
is_a: GO:0043231 ! intracellular membrane-bounded organelle
intersection_of: GO:0031988 ! membrane-bounded vesicle
intersection_of: part_of GO:0005737 ! cytoplasm
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0016024
name: CDP-diacylglycerol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate." [CHEBI:17962, GOC:curators]
subset: gosubset_prok
synonym: "CDP-diacylglycerol anabolism" EXACT []
synonym: "CDP-diacylglycerol biosynthesis" EXACT []
synonym: "CDP-diacylglycerol formation" EXACT []
synonym: "CDP-diacylglycerol synthesis" EXACT []
is_a: GO:0046341 ! CDP-diacylglycerol metabolic process
is_a: GO:0046474 ! glycerophospholipid biosynthetic process

[Term]
id: GO:0016025
name: obsolete proteasome endopeptidase regulator
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it does not represent a molecular function.
synonym: "proteasome endopeptidase regulator" EXACT []
is_obsolete: true
consider: GO:0004175

[Term]
id: GO:0016026
name: obsolete proteasome endopeptidase core
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it does not represent a molecular function.
synonym: "proteasome endopeptidase core" EXACT []
is_obsolete: true
consider: GO:0004175

[Term]
id: GO:0016027
name: inaD signaling complex
namespace: cellular_component
def: "A complex of proteins that are involved in phototransduction and attached to the transient receptor potential (TRP) channel. The protein connections are mediated through inaD." [GOC:hb, PMID:9010208, PMID:9796815]
synonym: "inaD signalling complex" EXACT []
is_a: GO:0044463 ! cell projection part
is_a: GO:0098797 ! plasma membrane protein complex
relationship: part_of GO:0016028 ! rhabdomere
relationship: part_of GO:0019897 ! extrinsic component of plasma membrane

[Term]
id: GO:0016028
name: rhabdomere
namespace: cellular_component
def: "The specialized microvilli-containing organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction." [GOC:hb, GOC:sart, PMID:8646774]
subset: goslim_pir
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0016029
name: subrhabdomeral cisterna
namespace: cellular_component
def: "A membrane-bounded compartment that is found at the base of the rhabdomere and contains stored calcium, InsP3 receptors and smooth endoplasmic reticulum Ca2+-ATPase." [PMID:11707492, PMID:8646774]
synonym: "SMC" RELATED []
synonym: "submicrovillar cisterna" EXACT [PMID:11707492]
is_a: GO:0044463 ! cell projection part
is_a: GO:0097425 ! smooth endoplasmic reticulum part
is_a: GO:0098827 ! endoplasmic reticulum subcompartment
relationship: part_of GO:0005790 ! smooth endoplasmic reticulum
relationship: part_of GO:0016028 ! rhabdomere

[Term]
id: GO:0016031
name: tRNA import into mitochondrion
namespace: biological_process
def: "The directed movement of tRNA, transfer ribonucleic acid, from the cytoplasm into a mitochondrion." [GOC:ma, PMID:10988073, PMID:11121736]
synonym: "cytoplasmic tRNA import into mitochondria" EXACT []
synonym: "cytoplasmic tRNA import into mitochondrion" NARROW [GOC:bf]
synonym: "cytoplasmic tRNA transport into mitochondrion" EXACT []
synonym: "cytoplasmic tRNA, mitochondrial import" EXACT []
synonym: "mitochondrial import of cytoplasmic tRNA" NARROW []
synonym: "nuclear-encoded tRNA import into mitochondrion" NARROW [GOC:bf]
is_a: GO:0035927 ! RNA import into mitochondrion
is_a: GO:0051031 ! tRNA transport

[Term]
id: GO:0016032
name: viral process
namespace: biological_process
alt_id: GO:0022415
def: "A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle." [GOC:bf, GOC:jl, GOC:mah]
comment: See also the biological process terms 'viral infectious cycle ; GO:0019058' and 'lysogeny ; GO:0030069'.
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_virus
synonym: "viral infection" RELATED []
synonym: "virulence" RELATED []
synonym: "virus process" EXACT [GOC:bf, GOC:jl]
xref: Reactome:REACT_6145 "Influenza Life Cycle, Homo sapiens"
xref: Reactome:REACT_6185 "HIV Infection, Homo sapiens"
xref: Reactome:REACT_6256 "HIV Life Cycle, Homo sapiens"
xref: Wikipedia:Viral_life_cycle
is_a: GO:0044403 ! symbiosis, encompassing mutualism through parasitism
is_a: GO:0044764 ! multi-organism cellular process

[Term]
id: GO:0016034
name: maleylacetoacetate isomerase activity
namespace: molecular_function
alt_id: GO:0018841
def: "Catalysis of the reaction: 4-maleylacetoacetate = 4-fumarylacetoacetate." [EC:5.2.1.2]
subset: gosubset_prok
synonym: "4-maleylacetoacetate cis-trans-isomerase activity" EXACT [EC:5.2.1.2]
synonym: "maleylacetoacetic isomerase activity" EXACT [EC:5.2.1.2]
synonym: "maleylacetone cis-trans-isomerase activity" EXACT [EC:5.2.1.2]
synonym: "maleylacetone isomerase activity" EXACT [EC:5.2.1.2]
xref: EC:5.2.1.2
xref: MetaCyc:MALEYLACETOACETATE-ISOMERASE-RXN
xref: Reactome:REACT_103260 "maleylacetoacetate => fumarylacetoacetate, Sus scrofa"
xref: Reactome:REACT_108874 "maleylacetoacetate => fumarylacetoacetate, Oryza sativa"
xref: Reactome:REACT_110933 "maleylacetoacetate => fumarylacetoacetate, Drosophila melanogaster"
xref: Reactome:REACT_1466 "maleylacetoacetate => fumarylacetoacetate, Homo sapiens"
xref: Reactome:REACT_28203 "maleylacetoacetate => fumarylacetoacetate, Taeniopygia guttata"
xref: Reactome:REACT_29692 "maleylacetoacetate => fumarylacetoacetate, Canis familiaris"
xref: Reactome:REACT_33946 "maleylacetoacetate => fumarylacetoacetate, Danio rerio"
xref: Reactome:REACT_78123 "maleylacetoacetate => fumarylacetoacetate, Bos taurus"
xref: Reactome:REACT_86111 "maleylacetoacetate => fumarylacetoacetate, Mus musculus"
xref: Reactome:REACT_87947 "maleylacetoacetate => fumarylacetoacetate, Caenorhabditis elegans"
xref: Reactome:REACT_89414 "maleylacetoacetate => fumarylacetoacetate, Gallus gallus"
xref: Reactome:REACT_93671 "maleylacetoacetate => fumarylacetoacetate, Xenopus tropicalis"
xref: Reactome:REACT_93694 "maleylacetoacetate => fumarylacetoacetate, Arabidopsis thaliana"
xref: Reactome:REACT_94496 "maleylacetoacetate => fumarylacetoacetate, Dictyostelium discoideum"
xref: RHEA:14820
xref: UM-BBD_reactionID:r0106
is_a: GO:0016859 ! cis-trans isomerase activity

[Term]
id: GO:0016035
name: zeta DNA polymerase complex
namespace: cellular_component
def: "A heterodimeric DNA polymerase complex that catalyzes error-prone DNA synthesis in contexts such as translesion synthesis and double-stranded break repair. First characterized in Saccharomyces, in which the subunits are Rev3p and Rev7p; a third protein, Rev1p, is often associated with the polymerase dimer." [PMID:16631579, PMID:16971464]
is_a: GO:0042575 ! DNA polymerase complex
is_a: GO:0044446 ! intracellular organelle part

[Term]
id: GO:0016036
name: cellular response to phosphate starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of phosphate." [GOC:jl]
subset: gosubset_prok
is_a: GO:0009267 ! cellular response to starvation

[Term]
id: GO:0016037
name: light absorption
namespace: biological_process
def: "The reception of a photon by a cell." [GOC:go_curators]
subset: gosubset_prok
synonym: "absorption of light" EXACT [GOC:curators]
is_a: GO:0044763 ! single-organism cellular process
relationship: part_of GO:0009583 ! detection of light stimulus

[Term]
id: GO:0016038
name: absorption of visible light
namespace: biological_process
def: "The reception of a (visible light) photon by a cell, visible light being defined as having a wavelength within the range 380-780 nm." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0016037 ! light absorption

[Term]
id: GO:0016039
name: absorption of UV light
namespace: biological_process
def: "The reception of a (UV light) photon by a cell, UV light being defined as having a wavelength within the range 13.6-400 nm." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0016037 ! light absorption

[Term]
id: GO:0016040
name: glutamate synthase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 L-glutamate + NAD(+) = 2-oxoglutarate + L-glutamine + H(+) + NADH." [EC:1.4.1.14, RHEA:13756]
subset: gosubset_prok
synonym: "glutamate (reduced nicotinamide adenine dinucleotide) synthase" EXACT [EC:1.4.1.14]
synonym: "L-glutamate synthase (NADH)" EXACT [EC:1.4.1.14]
synonym: "L-glutamate synthase activity" BROAD [EC:1.4.1.14]
synonym: "L-glutamate synthetase activity" BROAD [EC:1.4.1.14]
synonym: "L-glutamate:NAD+ oxidoreductase (transaminating)" EXACT [EC:1.4.1.14]
synonym: "NADH-dependent glutamate synthase activity" EXACT [EC:1.4.1.14]
synonym: "NADH-glutamate synthase activity" EXACT [EC:1.4.1.14]
synonym: "NADH: GOGAT" RELATED [EC:1.4.1.14]
xref: EC:1.4.1.14
xref: KEGG:R00093
xref: MetaCyc:GLUTAMATE-SYNTHASE-NADH-RXN
xref: RHEA:13756
is_a: GO:0045181 ! glutamate synthase activity, NAD(P)H as acceptor

[Term]
id: GO:0016041
name: glutamate synthase (ferredoxin) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 L-glutamate + 2 oxidized ferredoxin = L-glutamine + 2-oxoglutarate + 2 reduced ferredoxin + 2 H+. This is a two-step reaction: (a) L-glutamate + NH3 = L-glutamine + H2O, (b) L-glutamate + 2 oxidized ferredoxin + H2O = NH3 + 2-oxoglutarate + 2 reduced ferredoxin + 2 H+." [EC:1.4.7.1]
subset: gosubset_prok
synonym: "ferredoxin-dependent glutamate synthase activity" EXACT [EC:1.4.7.1]
synonym: "ferredoxin-glutamate synthase activity" EXACT [EC:1.4.7.1]
synonym: "glutamate synthase (ferredoxin-dependent)" EXACT [EC:1.4.7.1]
synonym: "L-glutamate:ferredoxin oxidoreductase (transaminating)" EXACT [EC:1.4.7.1]
xref: EC:1.4.7.1
xref: MetaCyc:GLUTAMATE-SYNTHASE-FERREDOXIN-RXN
xref: MetaCyc:PWY-4341
is_a: GO:0015930 ! glutamate synthase activity
is_a: GO:0016643 ! oxidoreductase activity, acting on the CH-NH2 group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0016042
name: lipid catabolic process
namespace: biological_process
alt_id: GO:0006724
def: "The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]
subset: gosubset_prok
synonym: "lipid breakdown" EXACT []
synonym: "lipid catabolism" EXACT []
synonym: "lipid degradation" EXACT []
synonym: "lipolysis" EXACT []
xref: Wikipedia:Lipid_catabolism
is_a: GO:0006629 ! lipid metabolic process
is_a: GO:0044712 ! single-organism catabolic process
is_a: GO:1901575 ! organic substance catabolic process

[Term]
id: GO:0016043
name: cellular component organization
namespace: biological_process
alt_id: GO:0044235
alt_id: GO:0071842
def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah]
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "cell organisation" EXACT []
synonym: "cell organization and biogenesis" RELATED [GOC:mah]
synonym: "cellular component organisation at cellular level" EXACT [GOC:mah]
synonym: "cellular component organisation in other organism" EXACT [GOC:mah]
synonym: "cellular component organization at cellular level" EXACT []
synonym: "cellular component organization in other organism" EXACT []
is_a: GO:0009987 ! cellular process
is_a: GO:0071840 ! cellular component organization or biogenesis

[Term]
id: GO:0016045
name: detection of bacterium
namespace: biological_process
alt_id: GO:0009598
alt_id: GO:0009681
def: "The series of events in which a stimulus from a bacterium is received and converted into a molecular signal." [GOC:hb]
synonym: "detection of bacteria" EXACT []
synonym: "perception of bacteria" RELATED []
synonym: "perception of bacterium" RELATED []
is_a: GO:0009617 ! response to bacterium
is_a: GO:0098543 ! detection of other organism

[Term]
id: GO:0016046
name: detection of fungus
namespace: biological_process
alt_id: GO:0009599
def: "The series of events in which a stimulus from a fungus is received and converted into a molecular signal." [GOC:hb]
synonym: "detection of fungi" EXACT []
synonym: "perception of fungi" RELATED []
synonym: "perception of fungus" RELATED []
is_a: GO:0009620 ! response to fungus
is_a: GO:0098543 ! detection of other organism

[Term]
id: GO:0016047
name: detection of parasitic fungus
namespace: biological_process
def: "The series of events in which a stimulus from a parasitic fungus (a fungus which spends all or part of its life in or on another organism from which it obtains nourishment and/or protection) is received and converted into a molecular signal." [GOC:hb, ISBN:0198506732]
synonym: "detection of parasitic fungi" EXACT []
synonym: "perception of parasitic fungi" RELATED []
synonym: "perception of parasitic fungus" RELATED []
is_a: GO:0009603 ! detection of symbiotic fungus
is_a: GO:0009623 ! response to parasitic fungus

[Term]
id: GO:0016048
name: detection of temperature stimulus
namespace: biological_process
def: "The series of events in which a temperature stimulus (hot or cold) is received and converted into a molecular signal." [GOC:hb]
synonym: "detection of temperature" EXACT []
synonym: "detection of thermal stimulus" EXACT []
synonym: "perception of temperature" RELATED []
is_a: GO:0009266 ! response to temperature stimulus
is_a: GO:0009581 ! detection of external stimulus
is_a: GO:0009582 ! detection of abiotic stimulus

[Term]
id: GO:0016049
name: cell growth
namespace: biological_process
alt_id: GO:0048591
def: "The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [GOC:ai]
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "cell expansion" RELATED []
synonym: "cellular growth" EXACT []
synonym: "growth of cell" EXACT []
synonym: "metabolic process resulting in cell growth" RELATED []
synonym: "metabolism resulting in cell growth" RELATED []
synonym: "non-developmental cell growth" RELATED [GOC:mah]
synonym: "non-developmental growth of a unicellular organism" RELATED [GOC:mah]
is_a: GO:0040007 ! growth
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0016050
name: vesicle organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle." [GOC:mah]
subset: goslim_pir
subset: goslim_yeast
synonym: "vesicle organisation" EXACT [GOC:curators]
synonym: "vesicle organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0016051
name: carbohydrate biosynthetic process
namespace: biological_process
alt_id: GO:0006093
def: "The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732]
subset: gosubset_prok
synonym: "anabolic carbohydrate metabolic process" EXACT []
synonym: "anabolic carbohydrate metabolism" EXACT []
synonym: "carbohydrate anabolism" EXACT []
synonym: "carbohydrate biosynthesis" EXACT []
synonym: "carbohydrate formation" EXACT []
synonym: "carbohydrate synthesis" EXACT []
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:0044723 ! single-organism carbohydrate metabolic process
is_a: GO:1901576 ! organic substance biosynthetic process

[Term]
id: GO:0016052
name: carbohydrate catabolic process
namespace: biological_process
alt_id: GO:0006095
def: "The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732]
subset: gosubset_prok
synonym: "carbohydrate breakdown" EXACT []
synonym: "carbohydrate catabolism" EXACT []
synonym: "carbohydrate degradation" EXACT []
synonym: "catabolic carbohydrate metabolic process" EXACT []
synonym: "catabolic carbohydrate metabolism" EXACT []
is_a: GO:0005975 ! carbohydrate metabolic process
is_a: GO:1901575 ! organic substance catabolic process

[Term]
id: GO:0016053
name: organic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732]
subset: gosubset_prok
synonym: "organic acid anabolism" EXACT []
synonym: "organic acid biosynthesis" EXACT []
synonym: "organic acid formation" EXACT []
synonym: "organic acid synthesis" EXACT []
is_a: GO:0006082 ! organic acid metabolic process
is_a: GO:0044249 ! cellular biosynthetic process
is_a: GO:0044283 ! small molecule biosynthetic process
is_a: GO:1901576 ! organic substance biosynthetic process

[Term]
id: GO:0016054
name: organic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732]
subset: gosubset_prok
synonym: "organic acid breakdown" EXACT []
synonym: "organic acid catabolism" EXACT []
synonym: "organic acid degradation" EXACT []
is_a: GO:0006082 ! organic acid metabolic process
is_a: GO:0044248 ! cellular catabolic process
is_a: GO:0044282 ! small molecule catabolic process
is_a: GO:1901575 ! organic substance catabolic process

[Term]
id: GO:0016055
name: Wnt signaling pathway
namespace: biological_process
alt_id: GO:0007222
def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397]
synonym: "frizzled signaling pathway" EXACT []
synonym: "frizzled signalling pathway" EXACT []
synonym: "Wg signaling pathway" EXACT [GOC:sart, PMID:8080429]
synonym: "Wg signalling pathway" EXACT [GOC:sart, PMID:8080429]
synonym: "Wingless signaling pathway" EXACT [GOC:sart, PMID:8080429]
synonym: "Wingless signalling pathway" EXACT [GOC:sart, PMID:8080429]
synonym: "Wnt receptor signaling pathway" EXACT [GOC:signaling]
synonym: "Wnt receptor signalling pathway" EXACT []
synonym: "Wnt-activated signaling pathway" RELATED []
is_a: GO:0007166 ! cell surface receptor signaling pathway

[Term]
id: GO:0016056
name: rhodopsin mediated signaling pathway
namespace: biological_process
alt_id: GO:0009586
def: "The series of molecular signals generated as a consequence of excitation of rhodopsin by a photon and the events that convert the absorbed photons into a cellular response." [GOC:bf, GOC:dph, GOC:hb, GOC:signaling, GOC:tb]
synonym: "rhodopsin mediated phototransduction" EXACT [GOC:bf]
synonym: "rhodopsin mediated signalling pathway" EXACT [GOC:dph, GOC:tb]
synonym: "rhodopsin signaling" EXACT [GOC:bf]
is_a: GO:0007186 ! G-protein coupled receptor signaling pathway
is_a: GO:0007602 ! phototransduction
is_a: GO:0071482 ! cellular response to light stimulus
relationship: part_of GO:0007603 ! phototransduction, visible light

[Term]
id: GO:0016057
name: regulation of membrane potential in photoreceptor cell
namespace: biological_process
def: "Hyperpolarization (vertebrates) or depolarization (invertebrates) of the photoreceptor cell membrane via closing/opening of cation specific channels as a result of signals generated by rhodopsin activation by a photon." [GOC:dph, GOC:hb, GOC:tb]
synonym: "changes in polarization state of photoreceptor cell membrane" EXACT [GOC:dph, GOC:tb]
is_a: GO:0042391 ! regulation of membrane potential

[Term]
id: GO:0016058
name: maintenance of membrane potential in photoreceptor cell by rhodopsin mediated signaling
namespace: biological_process
def: "Maintenance of the excited state of a photoreceptor cell to produce a steady-state current as a result of signals generated by rhodopsin activation by a photon." [GOC:dph, GOC:hb, GOC:tb]
synonym: "maintenance of rhodopsin mediated signaling" RELATED []
synonym: "maintenance of rhodopsin mediated signalling" EXACT []
is_a: GO:0016057 ! regulation of membrane potential in photoreceptor cell

[Term]
id: GO:0016059
name: deactivation of rhodopsin mediated signaling
namespace: biological_process
def: "The process of restoring the photoreceptor cell to its unexcited state after termination of the stimulus (photon)." [PMID:8316831]
synonym: "deactivation of rhodopsin mediated signalling" EXACT []
synonym: "rod response recovery" BROAD [GOC:bf]
is_a: GO:0022400 ! regulation of rhodopsin mediated signaling pathway

[Term]
id: GO:0016060
name: metarhodopsin inactivation
namespace: biological_process
def: "The process in which metarhodopsin is prevented from generating molecular signals. Activated rhodopsin (R*) is inactivated by a two-step process: first, R* is phosphorylated by rhodopsin kinase which lowers the activity of R*. Second, the protein arrestin binds to phosphorylated R* to de-activate it." [GOC:hb, Wikipedia:Visual_phototransduction]
is_a: GO:0009968 ! negative regulation of signal transduction
relationship: has_part GO:0004703 ! G-protein coupled receptor kinase activity
relationship: part_of GO:0016059 ! deactivation of rhodopsin mediated signaling

[Term]
id: GO:0016061
name: regulation of light-activated channel activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of light-activated channel activity." [GOC:go_curators]
is_a: GO:0032412 ! regulation of ion transmembrane transporter activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010461 ! light-activated ion channel activity
relationship: regulates GO:0010461 ! light-activated ion channel activity

[Term]
id: GO:0016062
name: adaptation of rhodopsin mediated signaling
namespace: biological_process
def: "The process in which a rhodopsin-mediated signaling pathway is adjusted to modulate the sensitivity and response of a visual system to light stimuli (that might vary over more than 6 magnitudes in intensity) without response saturation." [PMID:1962207]
synonym: "adaptation of rhodopsin mediated signalling" EXACT []
is_a: GO:0023058 ! adaptation of signaling pathway
relationship: part_of GO:0016056 ! rhodopsin mediated signaling pathway
relationship: part_of GO:0036367 ! light adaption

[Term]
id: GO:0016063
name: rhodopsin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas." [ISBN:0198506732]
synonym: "rhodopsin anabolism" EXACT []
synonym: "rhodopsin biosynthesis" EXACT []
synonym: "rhodopsin formation" EXACT []
synonym: "rhodopsin synthesis" EXACT []
is_a: GO:0006726 ! eye pigment biosynthetic process
is_a: GO:0044249 ! cellular biosynthetic process
is_a: GO:0046154 ! rhodopsin metabolic process

[Term]
id: GO:0016064
name: immunoglobulin mediated immune response
namespace: biological_process
def: "An immune response mediated by immunoglobulins, whether cell-bound or in solution." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was improved by GO_REF:0000022. It was renamed and redefined.
synonym: "antibody-mediated immune response" EXACT []
is_a: GO:0019724 ! B cell mediated immunity

[Term]
id: GO:0016065
name: obsolete humoral defense mechanism (sensu Protostomia)
namespace: biological_process
def: "OBSOLETE. The specific immune response mediated by antibodies. As in, but not restricted to, the taxon Protostomia (Protostomia, ncbi_taxonomy_id:33317)." [GOC:add, GOC:jid]
comment: This term was made obsolete because antibodies are not found in the taxon Protostomia.
synonym: "humoral defence mechanism (sensu Protostomia)" EXACT []
synonym: "humoral defense mechanism (sensu Protostomia)" EXACT []
is_obsolete: true

[Term]
id: GO:0016068
name: type I hypersensitivity
namespace: biological_process
def: "An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines." [GOC:add, ISBN:0781735149]
comment: Note that localized and systemic anaphylaxis is usually a result of type I hypersensitivity.
synonym: "immediate hypersensitivity response" EXACT []
xref: Wikipedia:Type_I_hypersensitivity
is_a: GO:0002524 ! hypersensitivity
is_a: GO:0016064 ! immunoglobulin mediated immune response

[Term]
id: GO:0016070
name: RNA metabolic process
namespace: biological_process
def: "The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732]
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_metagenomics
subset: goslim_pir
subset: gosubset_prok
synonym: "RNA metabolism" EXACT []
xref: Reactome:REACT_107259 "Metabolism of RNA, Sus scrofa"
xref: Reactome:REACT_107652 "Metabolism of RNA, Schizosaccharomyces pombe"
xref: Reactome:REACT_110289 "Metabolism of RNA, Danio rerio"
xref: Reactome:REACT_21257 "Metabolism of RNA, Homo sapiens"
xref: Reactome:REACT_30579 "Metabolism of RNA, Xenopus tropicalis"
xref: Reactome:REACT_31367 "Metabolism of RNA, Dictyostelium discoideum"
xref: Reactome:REACT_33720 "Metabolism of RNA, Plasmodium falciparum"
xref: Reactome:REACT_80071 "Metabolism of RNA, Caenorhabditis elegans"
xref: Reactome:REACT_83630 "Metabolism of RNA, Taeniopygia guttata"
xref: Reactome:REACT_84169 "Metabolism of RNA, Canis familiaris"
xref: Reactome:REACT_85788 "Metabolism of RNA, Oryza sativa"
xref: Reactome:REACT_88316 "Metabolism of RNA, Mus musculus"
xref: Reactome:REACT_89992 "Metabolism of RNA, Saccharomyces cerevisiae"
xref: Reactome:REACT_91556 "Metabolism of RNA, Bos taurus"
xref: Reactome:REACT_92152 "Metabolism of RNA, Drosophila melanogaster"
xref: Reactome:REACT_94876 "Metabolism of RNA, Arabidopsis thaliana"
xref: Reactome:REACT_99403 "Metabolism of RNA, Rattus norvegicus"
xref: Reactome:REACT_99885 "Metabolism of RNA, Gallus gallus"
is_a: GO:0044260 ! cellular macromolecule metabolic process
is_a: GO:0090304 ! nucleic acid metabolic process

[Term]
id: GO:0016071
name: mRNA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732]
subset: goslim_pombe
subset: gosubset_prok
synonym: "mRNA metabolism" EXACT []
xref: Reactome:REACT_100536 "Metabolism of mRNA, Dictyostelium discoideum"
xref: Reactome:REACT_107604 "Metabolism of mRNA, Danio rerio"
xref: Reactome:REACT_108700 "Metabolism of mRNA, Rattus norvegicus"
xref: Reactome:REACT_109292 "Metabolism of mRNA, Drosophila melanogaster"
xref: Reactome:REACT_109673 "Metabolism of mRNA, Canis familiaris"
xref: Reactome:REACT_109919 "Metabolism of mRNA, Gallus gallus"
xref: Reactome:REACT_20605 "Metabolism of mRNA, Homo sapiens"
xref: Reactome:REACT_28293 "Metabolism of mRNA, Sus scrofa"
xref: Reactome:REACT_29287 "Metabolism of mRNA, Xenopus tropicalis"
xref: Reactome:REACT_31547 "Metabolism of mRNA, Plasmodium falciparum"
xref: Reactome:REACT_32511 "Metabolism of mRNA, Arabidopsis thaliana"
xref: Reactome:REACT_33798 "Metabolism of mRNA, Bos taurus"
xref: Reactome:REACT_33846 "Metabolism of mRNA, Mus musculus"
xref: Reactome:REACT_34551 "Metabolism of mRNA, Oryza sativa"
xref: Reactome:REACT_78090 "Metabolism of mRNA, Caenorhabditis elegans"
xref: Reactome:REACT_84825 "Metabolism of mRNA, Taeniopygia guttata"
xref: Reactome:REACT_87161 "Metabolism of mRNA, Schizosaccharomyces pombe"
xref: Reactome:REACT_98319 "Metabolism of mRNA, Saccharomyces cerevisiae"
is_a: GO:0016070 ! RNA metabolic process

[Term]
id: GO:0016072
name: rRNA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving rRNA, ribosomal RNA, a structural constituent of ribosomes." [ISBN:0198506732]
subset: gosubset_prok
synonym: "rRNA metabolism" EXACT []
is_a: GO:0034660 ! ncRNA metabolic process

[Term]
id: GO:0016073
name: snRNA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving snRNA, small nuclear RNA, any of various low-molecular-mass RNA molecules found in the eukaryotic nucleus as components of the small nuclear ribonucleoprotein." [ISBN:0198506732]
synonym: "snRNA metabolism" EXACT []
is_a: GO:0034660 ! ncRNA metabolic process

[Term]
id: GO:0016074
name: snoRNA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving snoRNA, small nucleolar RNA, any of a class of small RNAs that are associated with the eukaryotic nucleus as components of small nucleolar ribonucleoproteins. They participate in the processing or modifications of many RNAs, mostly ribosomal RNAs (rRNAs) though snoRNAs are also known to target other classes of RNA, including spliceosomal RNAs, tRNAs, and mRNAs via a stretch of sequence that is complementary to a sequence in the targeted RNA." [GOC:krc]
subset: goslim_pombe
synonym: "snoRNA metabolism" EXACT []
is_a: GO:0034660 ! ncRNA metabolic process

[Term]
id: GO:0016075
name: rRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of rRNA, ribosomal RNA, a structural constituent of ribosomes." [GOC:ai]
subset: gosubset_prok
synonym: "rRNA breakdown" EXACT []
synonym: "rRNA catabolism" EXACT []
synonym: "rRNA degradation" EXACT []
is_a: GO:0016072 ! rRNA metabolic process
is_a: GO:0034661 ! ncRNA catabolic process

[Term]
id: GO:0016076
name: snRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of snRNA, small nuclear RNA, low-molecular-mass RNA molecules found in the eukaryotic nucleus as components of the small nuclear ribonucleoprotein." [ISBN:0198506732]
synonym: "snRNA breakdown" EXACT []
synonym: "snRNA catabolism" EXACT []
synonym: "snRNA degradation" EXACT []
is_a: GO:0016073 ! snRNA metabolic process
is_a: GO:0034661 ! ncRNA catabolic process

[Term]
id: GO:0016077
name: snoRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of snoRNA, small nucleolar RNA, any of a class of small RNAs that are associated with the eukaryotic nucleus as components of small nucleolar ribonucleoproteins." [ISBN:0198506732]
synonym: "snoRNA breakdown" EXACT []
synonym: "snoRNA catabolism" EXACT []
synonym: "snoRNA degradation" EXACT []
is_a: GO:0016074 ! snoRNA metabolic process
is_a: GO:0034661 ! ncRNA catabolic process

[Term]
id: GO:0016078
name: tRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis." [GOC:ai]
subset: gosubset_prok
synonym: "tRNA breakdown" EXACT []
synonym: "tRNA catabolism" EXACT []
synonym: "tRNA degradation" EXACT []
is_a: GO:0006399 ! tRNA metabolic process
is_a: GO:0034661 ! ncRNA catabolic process

[Term]
id: GO:0016079
name: synaptic vesicle exocytosis
namespace: biological_process
def: "Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft." [GOC:jid, GOC:lmg]
subset: goslim_synapse
is_a: GO:0017156 ! calcium ion regulated exocytosis
is_a: GO:0048489 ! synaptic vesicle transport
is_a: GO:0099531 ! presynaptic process involved in synaptic transmission
is_a: GO:0099643 ! signal release from synapse
relationship: part_of GO:0007269 ! neurotransmitter secretion
relationship: part_of GO:0099504 ! synaptic vesicle cycle

[Term]
id: GO:0016080
name: synaptic vesicle targeting
namespace: biological_process
def: "The process in which synaptic vesicles are directed to specific destination membranes, mediated by molecules at the vesicle membrane and target membrane surfaces." [GOC:mah]
is_a: GO:0006903 ! vesicle targeting
is_a: GO:0099531 ! presynaptic process involved in synaptic transmission
relationship: part_of GO:0016079 ! synaptic vesicle exocytosis

[Term]
id: GO:0016081
name: synaptic vesicle docking
namespace: biological_process
def: "The initial (indirect) attachment of a synaptic vesicle membrane to the presynaptic active zone membrane, mediated by proteins protruding from the membrane and proteins of the presynaptic active zone cytoplasmic component." [PMID:15217342]
comment: Although this process can occur outside of synaptic transmission, by convention we treat it as a part of synaptic transmission.  (dos, pvn, fk synapse project 2015)
subset: goslim_synapse
synonym: "synaptic vesicle docking during exocytosis" RELATED [GOC:dph, GOC:tb]
synonym: "synaptic vesicle docking involved in exocytosis" EXACT []
is_a: GO:0006904 ! vesicle docking involved in exocytosis
is_a: GO:0099531 ! presynaptic process involved in synaptic transmission
intersection_of: GO:0048278 ! vesicle docking
intersection_of: part_of GO:0016079 ! synaptic vesicle exocytosis
relationship: part_of GO:0016079 ! synaptic vesicle exocytosis

[Term]
id: GO:0016082
name: synaptic vesicle priming
namespace: biological_process
def: "A process that converts synaptic vesicles to a state of competence for calcium triggered fusion with the active zone membrane by bringing the two membranes into very close proximity. Priming typically (but not always) occurs after docking (Jahn and Fasshauer, 2012). Primed vesicles are also capable of spontaneously fusing with the active zone membrane." [GOC:mah, PMID:15217342] {comment="PMID:23060190"}
comment: Although this process can occur outside of synaptic transmission, by convention we treat it as a part of synaptic transmission.  (dos, pvn, fk synapse project 2015)
subset: goslim_synapse
is_a: GO:0043623 ! cellular protein complex assembly
is_a: GO:0099531 ! presynaptic process involved in synaptic transmission
relationship: part_of GO:0016079 ! synaptic vesicle exocytosis

[Term]
id: GO:0016083
name: obsolete synaptic vesicle fusion
namespace: biological_process
def: "OBSOLETE. Fusion of the synaptic vesicle with the postsynaptic membrane." [GOC:curators]
comment: This term was made obsolete because it was wrongly defined.
synonym: "synaptic vesicle fusion" EXACT []
is_obsolete: true
consider: GO:0016192

[Term]
id: GO:0016084
name: myostimulatory hormone activity
namespace: molecular_function
def: "The action characteristic of myostimulatory hormone, a peptide hormone that stimulates muscle contraction." [GOC:mah, PMID:12204246]
is_a: GO:0005179 ! hormone activity

[Term]
id: GO:0016085
name: myoinhibitory hormone activity
namespace: molecular_function
def: "The action characteristic of myostimulatory hormone, a peptide hormone that inhibits muscle contraction." [GOC:mah, PMID:8902848]
is_a: GO:0005179 ! hormone activity

[Term]
id: GO:0016086
name: obsolete allatostatin
namespace: molecular_function
def: "OBSOLETE. Peptide hormones produced by the corpora allata of insects that reversibly inhibit the production of juvenile hormone." [GOC:ai, PMID:10891383]
comment: This term was made obsolete because it refers to a gene product.
synonym: "allatostatin" EXACT []
is_obsolete: true
consider: GO:0005102
consider: GO:0045968

[Term]
id: GO:0016087
name: ecdysiostatic hormone activity
namespace: molecular_function
def: "The action characteristic of ecdysiostatic hormone, a peptide hormone that inhibits ecdysone secretion." [DOI:10.1002/(SICI)1520-6327(1997)35\:1, GOC:mah]
is_a: GO:0005184 ! neuropeptide hormone activity

[Term]
id: GO:0016088
name: obsolete insulin
namespace: molecular_function
def: "OBSOLETE. A polypeptide hormone that stimulates glucose uptake by muscle and adipose tissue, and promotes glycogenesis, lipogenesis and the synthesis of proteins and nucleic acids." [ISBN:0198506732]
comment: This term was made obsolete because it represents a gene product.
synonym: "insulin" EXACT []
is_obsolete: true
consider: GO:0005102
consider: GO:0045722
consider: GO:0045727
consider: GO:0045935
consider: GO:0046326
consider: GO:0046889

[Term]
id: GO:0016090
name: prenol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving prenols, isoprenoids of general formula (H-CH2-C(CH3)=CH-CH2-)n-OH, any primary monohydroxy alcohol whose carbon skeleton consists of two or more isoprenoid residues linked head to tail." [ISBN:0198547684]
subset: gosubset_prok
synonym: "prenol metabolism" EXACT []
is_a: GO:0006066 ! alcohol metabolic process
is_a: GO:0006720 ! isoprenoid metabolic process

[Term]
id: GO:0016091
name: prenol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of prenols, isoprenoids of general formula (H-CH2-C(CH3)=CH-CH2-)n-OH, any primary monohydroxy alcohol whose carbon skeleton consists of two or more isoprenoid residues linked head to tail." [GOC:go_curators]
subset: gosubset_prok
synonym: "prenol anabolism" EXACT []
synonym: "prenol biosynthesis" EXACT []
synonym: "prenol formation" EXACT []
synonym: "prenol synthesis" EXACT []
is_a: GO:0008299 ! isoprenoid biosynthetic process
is_a: GO:0016090 ! prenol metabolic process
is_a: GO:0046165 ! alcohol biosynthetic process

[Term]
id: GO:0016092
name: prenol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of prenols, isoprenoids of general formula (H-CH2-C(CH3)=CH-CH2-)n-OH, any primary monohydroxy alcohol whose carbon skeleton consists of two or more isoprenoid residues linked head to tail." [GOC:go_curators]
subset: gosubset_prok
synonym: "prenol breakdown" EXACT []
synonym: "prenol catabolism" EXACT []
synonym: "prenol degradation" EXACT []
is_a: GO:0008300 ! isoprenoid catabolic process
is_a: GO:0016090 ! prenol metabolic process
is_a: GO:0046164 ! alcohol catabolic process

[Term]
id: GO:0016093
name: polyprenol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving polyprenols, prenols with more than 4 isoprenoid residues, which may be all-trans, or a mixture of cis and trans." [http://www.chem.qmul.ac.uk/iupac/misc/prenol.html#p2, ISBN:0198547684]
subset: gosubset_prok
synonym: "polyprenol metabolism" EXACT []
is_a: GO:0006066 ! alcohol metabolic process
is_a: GO:0006720 ! isoprenoid metabolic process

[Term]
id: GO:0016094
name: polyprenol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of polyprenols, prenols with more than 4 isoprenoid residues, which may be all-trans, or a mixture of cis and trans." [GOC:go_curators, http://www.chem.qmul.ac.uk/iupac/misc/prenol.html#p2]
subset: gosubset_prok
synonym: "polyprenol anabolism" EXACT []
synonym: "polyprenol biosynthesis" EXACT []
synonym: "polyprenol formation" EXACT []
synonym: "polyprenol synthesis" EXACT []
is_a: GO:0008299 ! isoprenoid biosynthetic process
is_a: GO:0016093 ! polyprenol metabolic process
is_a: GO:0046165 ! alcohol biosynthetic process

[Term]
id: GO:0016095
name: polyprenol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of polyprenols, prenols with more than 4 isoprenoid residues, which may be all-trans, or a mixture of cis and trans." [GOC:go_curators, http://www.chem.qmul.ac.uk/iupac/misc/prenol.html#p2]
subset: gosubset_prok
synonym: "polyprenol breakdown" EXACT []
synonym: "polyprenol catabolism" EXACT []
synonym: "polyprenol degradation" EXACT []
is_a: GO:0008300 ! isoprenoid catabolic process
is_a: GO:0016093 ! polyprenol metabolic process
is_a: GO:0046164 ! alcohol catabolic process

[Term]
id: GO:0016098
name: monoterpenoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving monoterpenoid compounds, terpenoids having a C10 skeleton." [CHEBI:25409, ISBN:0198547684]
subset: gosubset_prok
synonym: "monoterpenoid metabolism" EXACT []
is_a: GO:0006721 ! terpenoid metabolic process

[Term]
id: GO:0016099
name: monoterpenoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of monoterpenoid compounds, terpenoids having a C10 skeleton." [CHEBI:25409]
subset: gosubset_prok
synonym: "monoterpenoid anabolism" EXACT []
synonym: "monoterpenoid biosynthesis" EXACT []
synonym: "monoterpenoid formation" EXACT []
synonym: "monoterpenoid synthesis" EXACT []
xref: MetaCyc:PWY-3041
is_a: GO:0016098 ! monoterpenoid metabolic process
is_a: GO:0016114 ! terpenoid biosynthetic process

[Term]
id: GO:0016100
name: monoterpenoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of monoterpenoid compounds, terpenoids having a C10 skeleton." [CHEBI:25409]
subset: gosubset_prok
synonym: "monoterpenoid breakdown" EXACT []
synonym: "monoterpenoid catabolism" EXACT []
synonym: "monoterpenoid degradation" EXACT []
is_a: GO:0016098 ! monoterpenoid metabolic process
is_a: GO:0016115 ! terpenoid catabolic process

[Term]
id: GO:0016101
name: diterpenoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving diterpenoid compounds, terpenoids with four isoprene units." [ISBN:0198547684]
subset: gosubset_prok
synonym: "diterpene metabolic process" NARROW []
synonym: "diterpene metabolism" NARROW []
synonym: "diterpenoid metabolism" EXACT []
is_a: GO:0006721 ! terpenoid metabolic process

[Term]
id: GO:0016102
name: diterpenoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of diterpenoid compounds, terpenoids with four isoprene units." [GOC:mah, ISBN:0198547684]
subset: gosubset_prok
synonym: "diterpene biosynthesis" NARROW []
synonym: "diterpene biosynthetic process" NARROW []
synonym: "diterpenoid anabolism" EXACT []
synonym: "diterpenoid biosynthesis" EXACT []
synonym: "diterpenoid formation" EXACT []
synonym: "diterpenoid synthesis" EXACT []
is_a: GO:0016101 ! diterpenoid metabolic process
is_a: GO:0016114 ! terpenoid biosynthetic process

[Term]
id: GO:0016103
name: diterpenoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of diterpenoid compounds, terpenoids with four isoprene units." [GOC:mah, ISBN:0198547684]
subset: gosubset_prok
synonym: "diterpene catabolic process" NARROW []
synonym: "diterpene catabolism" NARROW []
synonym: "diterpenoid breakdown" EXACT []
synonym: "diterpenoid catabolism" EXACT []
synonym: "diterpenoid degradation" EXACT []
is_a: GO:0016101 ! diterpenoid metabolic process
is_a: GO:0016115 ! terpenoid catabolic process

[Term]
id: GO:0016104
name: triterpenoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of triterpenoid compounds, terpenoids with six isoprene units." [GOC:go_curators]
subset: gosubset_prok
synonym: "triterpene biosynthesis" NARROW []
synonym: "triterpene biosynthetic process" NARROW []
synonym: "triterpenoid anabolism" EXACT []
synonym: "triterpenoid biosynthesis" EXACT []
synonym: "triterpenoid formation" EXACT []
synonym: "triterpenoid synthesis" EXACT []
is_a: GO:0006722 ! triterpenoid metabolic process
is_a: GO:0016114 ! terpenoid biosynthetic process

[Term]
id: GO:0016105
name: triterpenoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of triterpenoid compounds, terpenoids with six isoprene units." [GOC:go_curators]
subset: gosubset_prok
synonym: "triterpene catabolic process" NARROW []
synonym: "triterpene catabolism" NARROW []
synonym: "triterpenoid breakdown" EXACT []
synonym: "triterpenoid catabolism" EXACT []
synonym: "triterpenoid degradation" EXACT []
is_a: GO:0006722 ! triterpenoid metabolic process
is_a: GO:0016115 ! terpenoid catabolic process

[Term]
id: GO:0016106
name: sesquiterpenoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sesquiterpenoid compounds, terpenoids with three isoprene units." [GOC:go_curators]
subset: gosubset_prok
synonym: "sesquiterpenoid anabolism" EXACT []
synonym: "sesquiterpenoid biosynthesis" EXACT []
synonym: "sesquiterpenoid formation" EXACT []
synonym: "sesquiterpenoid synthesis" EXACT []
is_a: GO:0006714 ! sesquiterpenoid metabolic process
is_a: GO:0016114 ! terpenoid biosynthetic process

[Term]
id: GO:0016107
name: sesquiterpenoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of sesquiterpenoid compounds, terpenoids with three isoprene units." [GOC:go_curators]
subset: gosubset_prok
synonym: "sesquiterpenoid breakdown" EXACT []
synonym: "sesquiterpenoid catabolism" EXACT []
synonym: "sesquiterpenoid degradation" EXACT []
is_a: GO:0006714 ! sesquiterpenoid metabolic process
is_a: GO:0016115 ! terpenoid catabolic process

[Term]
id: GO:0016108
name: tetraterpenoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tetraterpenoid compounds, terpenoids with eight isoprene units." [ISBN:0198547684]
subset: gosubset_prok
synonym: "tetraterpene metabolic process" NARROW []
synonym: "tetraterpene metabolism" NARROW []
synonym: "tetraterpenoid metabolism" EXACT []
is_a: GO:0006721 ! terpenoid metabolic process

[Term]
id: GO:0016109
name: tetraterpenoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tetraterpenoid compounds, terpenoids with eight isoprene units." [GOC:go_curators]
subset: gosubset_prok
synonym: "tetraterpene biosynthesis" NARROW []
synonym: "tetraterpene biosynthetic process" NARROW []
synonym: "tetraterpenoid anabolism" EXACT []
synonym: "tetraterpenoid biosynthesis" EXACT []
synonym: "tetraterpenoid formation" EXACT []
synonym: "tetraterpenoid synthesis" EXACT []
is_a: GO:0016108 ! tetraterpenoid metabolic process
is_a: GO:0016114 ! terpenoid biosynthetic process

[Term]
id: GO:0016110
name: tetraterpenoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tetraterpenoid compounds, terpenoids with eight isoprene units." [GOC:go_curators]
subset: gosubset_prok
synonym: "tetraterpene catabolic process" NARROW []
synonym: "tetraterpene catabolism" NARROW []
synonym: "tetraterpenoid breakdown" EXACT []
synonym: "tetraterpenoid catabolism" EXACT []
synonym: "tetraterpenoid degradation" EXACT []
is_a: GO:0016108 ! tetraterpenoid metabolic process
is_a: GO:0016115 ! terpenoid catabolic process

[Term]
id: GO:0016111
name: polyterpenoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving polyterpenoid compounds, terpenoids with more than eight isoprene units." [ISBN:0198547684]
subset: gosubset_prok
synonym: "polyterpene metabolic process" NARROW []
synonym: "polyterpene metabolism" NARROW []
synonym: "polyterpenoid metabolism" EXACT []
is_a: GO:0006721 ! terpenoid metabolic process

[Term]
id: GO:0016112
name: polyterpenoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of polyterpenoid compounds, terpenoids with more than eight isoprene units." [GOC:go_curators]
subset: gosubset_prok
synonym: "polyterpene biosynthesis" NARROW []
synonym: "polyterpene biosynthetic process" NARROW []
synonym: "polyterpenoid anabolism" EXACT []
synonym: "polyterpenoid biosynthesis" EXACT []
synonym: "polyterpenoid formation" EXACT []
synonym: "polyterpenoid synthesis" EXACT []
is_a: GO:0016111 ! polyterpenoid metabolic process
is_a: GO:0016114 ! terpenoid biosynthetic process

[Term]
id: GO:0016113
name: polyterpenoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of polyterpenoid compounds, terpenoids with more than eight isoprene units." [GOC:go_curators]
subset: gosubset_prok
synonym: "polyterpene catabolic process" NARROW []
synonym: "polyterpene catabolism" NARROW []
synonym: "polyterpenoid breakdown" EXACT []
synonym: "polyterpenoid catabolism" EXACT []
synonym: "polyterpenoid degradation" EXACT []
is_a: GO:0016111 ! polyterpenoid metabolic process
is_a: GO:0016115 ! terpenoid catabolic process

[Term]
id: GO:0016114
name: terpenoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure." [GOC:ai]
subset: gosubset_prok
synonym: "terpenoid anabolism" EXACT []
synonym: "terpenoid biosynthesis" EXACT []
synonym: "terpenoid formation" EXACT []
synonym: "terpenoid synthesis" EXACT []
xref: Wikipedia:Terpenoid
is_a: GO:0006721 ! terpenoid metabolic process
is_a: GO:0008299 ! isoprenoid biosynthetic process

[Term]
id: GO:0016115
name: terpenoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure." [GOC:ai]
subset: gosubset_prok
synonym: "terpenoid breakdown" EXACT []
synonym: "terpenoid catabolism" EXACT []
synonym: "terpenoid degradation" EXACT []
is_a: GO:0006721 ! terpenoid metabolic process
is_a: GO:0008300 ! isoprenoid catabolic process

[Term]
id: GO:0016116
name: carotenoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [ISBN:0198547684]
subset: gosubset_prok
synonym: "carotenoid metabolism" EXACT []
is_a: GO:0016108 ! tetraterpenoid metabolic process

[Term]
id: GO:0016117
name: carotenoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [GOC:go_curators]
subset: gosubset_prok
synonym: "carotenoid anabolism" EXACT []
synonym: "carotenoid biosynthesis" EXACT []
synonym: "carotenoid formation" EXACT []
synonym: "carotenoid synthesis" EXACT []
xref: MetaCyc:CAROTENOID-PWY
is_a: GO:0016109 ! tetraterpenoid biosynthetic process
is_a: GO:0016116 ! carotenoid metabolic process
is_a: GO:0046148 ! pigment biosynthetic process

[Term]
id: GO:0016118
name: carotenoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [GOC:go_curators]
subset: gosubset_prok
synonym: "carotenoid breakdown" EXACT []
synonym: "carotenoid catabolism" EXACT []
synonym: "carotenoid degradation" EXACT []
is_a: GO:0016110 ! tetraterpenoid catabolic process
is_a: GO:0016116 ! carotenoid metabolic process

[Term]
id: GO:0016119
name: carotene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving carotenes, hydrocarbon carotenoids." [ISBN:0198547684]
subset: gosubset_prok
synonym: "carotene metabolism" EXACT []
is_a: GO:0042214 ! terpene metabolic process

[Term]
id: GO:0016120
name: carotene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of carotenes, hydrocarbon carotenoids." [GOC:go_curators]
subset: gosubset_prok
synonym: "carotene anabolism" EXACT []
synonym: "carotene biosynthesis" EXACT []
synonym: "carotene formation" EXACT []
synonym: "carotene synthesis" EXACT []
is_a: GO:0016119 ! carotene metabolic process
is_a: GO:0046246 ! terpene biosynthetic process

[Term]
id: GO:0016121
name: carotene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of carotenes, hydrocarbon carotenoids." [GOC:go_curators]
subset: gosubset_prok
synonym: "carotene breakdown" EXACT []
synonym: "carotene catabolism" EXACT []
synonym: "carotene degradation" EXACT []
is_a: GO:0016119 ! carotene metabolic process
is_a: GO:0046247 ! terpene catabolic process

[Term]
id: GO:0016122
name: xanthophyll metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving xanthophylls, oxygen-containing carotenoids." [ISBN:0198547684]
subset: gosubset_prok
synonym: "xanthophyll metabolism" EXACT []
is_a: GO:0016116 ! carotenoid metabolic process

[Term]
id: GO:0016123
name: xanthophyll biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of xanthophylls, oxygen-containing carotenoids." [GOC:go_curators]
subset: gosubset_prok
synonym: "xanthophyll anabolism" EXACT []
synonym: "xanthophyll biosynthesis" EXACT []
synonym: "xanthophyll formation" EXACT []
synonym: "xanthophyll synthesis" EXACT []
is_a: GO:0016117 ! carotenoid biosynthetic process
is_a: GO:0016122 ! xanthophyll metabolic process

[Term]
id: GO:0016124
name: xanthophyll catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of xanthophylls, oxygen-containing carotenoids." [GOC:go_curators]
subset: gosubset_prok
synonym: "xanthophyll breakdown" EXACT []
synonym: "xanthophyll catabolism" EXACT []
synonym: "xanthophyll degradation" EXACT []
is_a: GO:0016118 ! carotenoid catabolic process
is_a: GO:0016122 ! xanthophyll metabolic process

[Term]
id: GO:0016125
name: sterol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [ISBN:0198547684]
subset: gosubset_prok
synonym: "sterol metabolism" EXACT []
is_a: GO:0006066 ! alcohol metabolic process
is_a: GO:0008202 ! steroid metabolic process

[Term]
id: GO:0016126
name: sterol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:go_curators]
subset: gosubset_prok
synonym: "sterol anabolism" EXACT []
synonym: "sterol biosynthesis" EXACT []
synonym: "sterol formation" EXACT []
synonym: "sterol synthesis" EXACT []
xref: MetaCyc:PWY-2541
is_a: GO:0006694 ! steroid biosynthetic process
is_a: GO:0016125 ! sterol metabolic process
is_a: GO:0046165 ! alcohol biosynthetic process

[Term]
id: GO:0016127
name: sterol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:go_curators]
subset: gosubset_prok
synonym: "sterol breakdown" EXACT []
synonym: "sterol catabolism" EXACT []
synonym: "sterol degradation" EXACT []
is_a: GO:0006706 ! steroid catabolic process
is_a: GO:0016125 ! sterol metabolic process
is_a: GO:0046164 ! alcohol catabolic process

[Term]
id: GO:0016128
name: phytosteroid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phytosteroids, steroids of higher plants that differ from animal steroids in having substitutions at C24 and/or a double bond at C22. Phytosteroids are so named because they occur in higher plants; some, notably ergosterol, are also found in fungi." [GOC:mah, ISBN:0198547684]
subset: gosubset_prok
synonym: "phytosteroid metabolism" EXACT []
is_a: GO:0006066 ! alcohol metabolic process
is_a: GO:0008202 ! steroid metabolic process

[Term]
id: GO:0016129
name: phytosteroid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phytosteroids, steroids that differ from animal steroids in having substitutions at C24 and/or a double bond at C22. Phytosteroids are so named because they occur in higher plants; some, notably ergosterol, are also found in fungi." [GOC:go_curators, GOC:mah, ISBN:0471331309]
subset: gosubset_prok
synonym: "phytosteroid anabolism" EXACT []
synonym: "phytosteroid biosynthesis" EXACT []
synonym: "phytosteroid formation" EXACT []
synonym: "phytosteroid synthesis" EXACT []
is_a: GO:0006694 ! steroid biosynthetic process
is_a: GO:0016128 ! phytosteroid metabolic process
is_a: GO:0046165 ! alcohol biosynthetic process

[Term]
id: GO:0016130
name: phytosteroid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phytosteroids, steroids that differ from animal steroids in having substitutions at C24 and/or a double bond at C22. Phytosteroids are so named because they occur in higher plants; some, notably ergosterol, are also found in fungi." [GOC:go_curators, GOC:mah]
subset: gosubset_prok
synonym: "phytosteroid breakdown" EXACT []
synonym: "phytosteroid catabolism" EXACT []
synonym: "phytosteroid degradation" EXACT []
is_a: GO:0006706 ! steroid catabolic process
is_a: GO:0016128 ! phytosteroid metabolic process
is_a: GO:0046164 ! alcohol catabolic process

[Term]
id: GO:0016131
name: brassinosteroid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving brassinosteroids, any of a group of steroid derivatives that occur at very low concentrations in plant tissues and may have hormone-like effects." [ISBN:0192801023]
subset: gosubset_prok
synonym: "brassinosteroid metabolism" EXACT []
is_a: GO:0016128 ! phytosteroid metabolic process
is_a: GO:0042445 ! hormone metabolic process

[Term]
id: GO:0016132
name: brassinosteroid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of brassinosteroids, any of a group of steroid derivatives that occur at very low concentrations in plant tissues and may have hormone-like effects." [ISBN:0192801023]
subset: gosubset_prok
synonym: "brassinosteroid anabolism" EXACT []
synonym: "brassinosteroid biosynthesis" EXACT []
synonym: "brassinosteroid formation" EXACT []
synonym: "brassinosteroid synthesis" EXACT []
xref: MetaCyc:PWY-2582
xref: MetaCyc:PWY-699
is_a: GO:0016129 ! phytosteroid biosynthetic process
is_a: GO:0016131 ! brassinosteroid metabolic process
is_a: GO:0042446 ! hormone biosynthetic process

[Term]
id: GO:0016133
name: brassinosteroid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of brassinosteroids, any of a group of steroid derivatives that occur at very low concentrations in plant tissues and may have hormone-like effects." [ISBN:0192801023]
subset: gosubset_prok
synonym: "brassinosteroid breakdown" EXACT []
synonym: "brassinosteroid catabolism" EXACT []
synonym: "brassinosteroid degradation" EXACT []
is_a: GO:0016130 ! phytosteroid catabolic process
is_a: GO:0016131 ! brassinosteroid metabolic process
is_a: GO:0042447 ! hormone catabolic process

[Term]
id: GO:0016134
name: saponin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving saponins, glycosides of plants in which the aglycan (sapogenin) group is a terpene or steroid and the sugar group is a glucose, a galactose, a pentose, a methylpentose or an oligosaccharide. Saponins are powerful surfactant agents and membrane active; they are, hence, toxic to animals on injection." [ISBN:0198547684]
subset: gosubset_prok
synonym: "saponin metabolism" EXACT []
is_a: GO:0016137 ! glycoside metabolic process

[Term]
id: GO:0016135
name: saponin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of saponins, glycosides of plants in which the aglycan (sapogenin) group is a terpene or steroid and the sugar group is a glucose, a galactose, a pentose, a methylpentose or an oligosaccharide. Saponins are powerful surfactant agents and membrane active; they are, hence, toxic to animals on injection." [GOC:go_curators]
subset: gosubset_prok
synonym: "saponin anabolism" EXACT []
synonym: "saponin biosynthesis" EXACT []
synonym: "saponin formation" EXACT []
synonym: "saponin synthesis" EXACT []
is_a: GO:0016134 ! saponin metabolic process
is_a: GO:0016138 ! glycoside biosynthetic process

[Term]
id: GO:0016136
name: saponin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of saponins, glycosides of plants in which the aglycan (sapogenin) group is a terpene or steroid and the sugar group is a glucose, a galactose, a pentose, a methylpentose or an oligosaccharide. Saponins are powerful surfactant agents and membrane active; they are, hence, toxic to animals on injection." [GOC:go_curators]
subset: gosubset_prok
synonym: "saponin breakdown" EXACT []
synonym: "saponin catabolism" EXACT []
synonym: "saponin degradation" EXACT []
is_a: GO:0016134 ! saponin metabolic process
is_a: GO:0016139 ! glycoside catabolic process

[Term]
id: GO:0016137
name: glycoside metabolic process
namespace: biological_process
alt_id: GO:0016140
def: "The chemical reactions and pathways involving glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." [ISBN:0198547684]
subset: gosubset_prok
synonym: "glycoside metabolism" EXACT []
synonym: "O-glycoside metabolic process" EXACT []
synonym: "O-glycoside metabolism" EXACT []
is_a: GO:1901657 ! glycosyl compound metabolic process

[Term]
id: GO:0016138
name: glycoside biosynthetic process
namespace: biological_process
alt_id: GO:0016141
def: "The chemical reactions and pathways resulting in the formation of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." [GOC:go_curators]
subset: gosubset_prok
synonym: "glycoside anabolism" EXACT []
synonym: "glycoside biosynthesis" EXACT []
synonym: "glycoside formation" EXACT []
synonym: "glycoside synthesis" EXACT []
synonym: "O-glycoside anabolism" EXACT []
synonym: "O-glycoside biosynthesis" EXACT []
synonym: "O-glycoside biosynthetic process" EXACT []
synonym: "O-glycoside formation" EXACT []
synonym: "O-glycoside synthesis" EXACT []
is_a: GO:0016137 ! glycoside metabolic process
is_a: GO:1901659 ! glycosyl compound biosynthetic process

[Term]
id: GO:0016139
name: glycoside catabolic process
namespace: biological_process
alt_id: GO:0016142
def: "The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." [GOC:go_curators]
subset: gosubset_prok
synonym: "glycoside breakdown" EXACT []
synonym: "glycoside catabolism" EXACT []
synonym: "glycoside degradation" EXACT []
synonym: "O-glycoside breakdown" EXACT []
synonym: "O-glycoside catabolic process" EXACT []
synonym: "O-glycoside catabolism" EXACT []
synonym: "O-glycoside degradation" EXACT []
is_a: GO:0016137 ! glycoside metabolic process
is_a: GO:1901658 ! glycosyl compound catabolic process

[Term]
id: GO:0016143
name: S-glycoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving S-glycosides, any compound in which a glycosyl group has been substituted into a thiol group." [ISBN:0198506732]
subset: gosubset_prok
synonym: "S-glycoside metabolism" EXACT []
synonym: "thioglycoside metabolic process" EXACT []
synonym: "thioglycoside metabolism" EXACT []
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:1901657 ! glycosyl compound metabolic process

[Term]
id: GO:0016144
name: S-glycoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of S-glycosides, any compound in which a glycosyl group has been substituted into a thiol group." [ISBN:0198506732]
subset: gosubset_prok
synonym: "S-glycoside anabolism" EXACT []
synonym: "S-glycoside biosynthesis" EXACT []
synonym: "S-glycoside formation" EXACT []
synonym: "S-glycoside synthesis" EXACT []
synonym: "thioglycoside biosynthesis" EXACT []
synonym: "thioglycoside biosynthetic process" EXACT []
is_a: GO:0016143 ! S-glycoside metabolic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:1901659 ! glycosyl compound biosynthetic process

[Term]
id: GO:0016145
name: S-glycoside catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of S-glycosides, any compound in which a glycosyl group has been substituted into a thiol group." [ISBN:0198506732]
subset: gosubset_prok
synonym: "S-glycoside breakdown" EXACT []
synonym: "S-glycoside catabolism" EXACT []
synonym: "S-glycoside degradation" EXACT []
synonym: "thioglycoside catabolic process" EXACT []
synonym: "thioglycoside catabolism" EXACT []
is_a: GO:0016143 ! S-glycoside metabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:1901658 ! glycosyl compound catabolic process

[Term]
id: GO:0016146
name: obsolete protein-synthesizing GTPase activity, initiation
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.48]
comment: This term was made obsolete because it contains both process and function information.
synonym: "protein-synthesizing GTPase activity, initiation" EXACT []
is_obsolete: true
consider: GO:0003743
consider: GO:0003924
consider: GO:0006412
consider: GO:0006413

[Term]
id: GO:0016147
name: obsolete protein-synthesizing GTPase activity, elongation
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.48]
comment: This term was made obsolete because it contains both process and function information.
synonym: "protein-synthesizing GTPase activity, elongation" EXACT []
is_obsolete: true
consider: GO:0003746
consider: GO:0003924
consider: GO:0006412
consider: GO:0006414

[Term]
id: GO:0016148
name: obsolete protein-synthesizing GTPase activity, termination
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.48]
comment: This term was made obsolete because it contains both process and function information.
synonym: "protein-synthesizing GTPase activity, termination" EXACT []
is_obsolete: true
consider: GO:0003924
consider: GO:0006412
consider: GO:0006415
consider: GO:0008079

[Term]
id: GO:0016149
name: translation release factor activity, codon specific
namespace: molecular_function
def: "A translation release factor that is specific for one or more particular termination codons; acts at the ribosomal A-site and require polypeptidyl-tRNA at the P-site." [ISBN:0198547684]
subset: gosubset_prok
is_a: GO:0003747 ! translation release factor activity

[Term]
id: GO:0016150
name: translation release factor activity, codon nonspecific
namespace: molecular_function
def: "A translation release factor that is not specific to particular codons; binds to guanine nucleotides." [ISBN:0198547684]
is_a: GO:0003747 ! translation release factor activity

[Term]
id: GO:0016151
name: nickel cation binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with nickel (Ni) cations." [GOC:ai]
subset: gosubset_prok
synonym: "nickel binding" EXACT []
is_a: GO:0046914 ! transition metal ion binding

[Term]
id: GO:0016152
name: mercury (II) reductase activity
namespace: molecular_function
alt_id: GO:0018692
def: "Catalysis of the reaction: H(+) + Hg + NADP(+) = Hg(2+) + NADPH." [EC:1.16.1.1, RHEA:23859]
subset: gosubset_prok
synonym: "Hg:NADP+ oxidoreductase activity" EXACT [EC:1.16.1.1]
synonym: "mer A" RELATED [EC:1.16.1.1]
synonym: "mercurate(II) reductase activity" EXACT [EC:1.16.1.1]
synonym: "mercuric ion reductase activity" EXACT [EC:1.16.1.1]
synonym: "mercuric reductase activity" EXACT [EC:1.16.1.1]
synonym: "mercury reductase activity" EXACT [EC:1.16.1.1]
synonym: "mercury(II) reductase activity" EXACT [EC:1.16.1.1]
synonym: "reduced NADP:mercuric ion oxidoreductase activity" EXACT [EC:1.16.1.1]
xref: EC:1.16.1.1
xref: KEGG:R02807
xref: MetaCyc:MERCURY-II-REDUCTASE-RXN
xref: RHEA:23859
xref: UM-BBD_reactionID:r0406
is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor

[Term]
id: GO:0016153
name: urocanate hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-imidazolone-5-propanoate + H(+) = trans-urocanate + H(2)O." [EC:4.2.1.49, RHEA:13104]
subset: gosubset_prok
synonym: "3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate hydro-lyase (urocanate-forming)" EXACT [EC:4.2.1.49]
synonym: "3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate hydro-lyase activity" EXACT [EC:4.2.1.49]
synonym: "imidazolonepropionate hydrolase activity" EXACT [EC:4.2.1.49]
synonym: "urocanase activity" EXACT [EC:4.2.1.49]
xref: EC:4.2.1.49
xref: KEGG:R02914
xref: MetaCyc:UROCANATE-HYDRATASE-RXN
xref: Reactome:REACT_102097 "urocanate + H2O => 4-imidazolone-5-propionate, Canis familiaris"
xref: Reactome:REACT_103396 "urocanate + H2O => 4-imidazolone-5-propionate, Danio rerio"
xref: Reactome:REACT_108112 "urocanate + H2O => 4-imidazolone-5-propionate, Bos taurus"
xref: Reactome:REACT_109123 "urocanate + H2O => 4-imidazolone-5-propionate, Caenorhabditis elegans"
xref: Reactome:REACT_109939 "urocanate + H2O => 4-imidazolone-5-propionate, Gallus gallus"
xref: Reactome:REACT_1166 "urocanate + H2O => 4-imidazolone-5-propionate, Homo sapiens"
xref: Reactome:REACT_29286 "urocanate + H2O => 4-imidazolone-5-propionate, Dictyostelium discoideum"
xref: Reactome:REACT_33847 "urocanate + H2O => 4-imidazolone-5-propionate, Staphylococcus aureus N315"
xref: Reactome:REACT_77247 "urocanate + H2O => 4-imidazolone-5-propionate, Xenopus tropicalis"
xref: Reactome:REACT_77904 "urocanate + H2O => 4-imidazolone-5-propionate, Taeniopygia guttata"
xref: Reactome:REACT_90706 "urocanate + H2O => 4-imidazolone-5-propionate, Sus scrofa"
xref: Reactome:REACT_92891 "urocanate + H2O => 4-imidazolone-5-propionate, Rattus norvegicus"
xref: Reactome:REACT_97022 "urocanate + H2O => 4-imidazolone-5-propionate, Mus musculus"
xref: RHEA:13104
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0016154
name: pyrimidine-nucleoside phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyrimidine nucleoside + phosphate = pyrimidine + alpha-D-ribose 1-phosphate." [EC:2.4.2.2]
subset: gosubset_prok
synonym: "Py-NPase activity" EXACT [EC:2.4.2.2]
synonym: "pyrimidine-nucleoside:phosphate alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.2]
xref: EC:2.4.2.2
xref: MetaCyc:PYRIMIDINE-NUCLEOSIDE-PHOSPHORYLASE-RXN
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0016155
name: formyltetrahydrofolate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 10-formyltetrahydrofolate + H(2)O + NADP(+) = (6S)-5,6,7,8-tetrahydrofolate + CO(2) + H(+) + NADPH." [EC:1.5.1.6, RHEA:10183]
synonym: "10-formyl tetrahydrofolate:NADP oxidoreductase activity" EXACT [EC:1.5.1.6]
synonym: "10-formyl-H2PtGlu:NADP oxidoreductase activity" EXACT [EC:1.5.1.6]
synonym: "10-formyl-H4folate dehydrogenase activity" EXACT [EC:1.5.1.6]
synonym: "10-formyltetrahydrofolate dehydrogenase activity" EXACT [EC:1.5.1.6]
synonym: "10-formyltetrahydrofolate:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.6]
synonym: "N10-formyltetrahydrofolate dehydrogenase activity" EXACT [EC:1.5.1.6]
xref: EC:1.5.1.6
xref: KEGG:R00941
xref: MetaCyc:FORMYLTETRAHYDROFOLATE-DEHYDROGENASE-RXN
xref: RHEA:10183
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0016156
name: fumarate reductase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(+) + succinate = fumarate + H(+) + NADH." [EC:1.3.1.6, RHEA:18284]
subset: gosubset_prok
synonym: "NADH-dependent fumarate reductase activity" EXACT [EC:1.3.1.6]
synonym: "NADH-fumarate reductase activity" EXACT [EC:1.3.1.6]
synonym: "succinate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.6]
xref: EC:1.3.1.6
xref: KEGG:R00402
xref: MetaCyc:FUMARATE-REDUCTASE-NADH-RXN
xref: RHEA:18284
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0016157
name: sucrose synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + D-fructose = UDP + sucrose." [EC:2.4.1.13]
subset: gosubset_prok
synonym: "NDP-glucose:D-fructose 2-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.13]
synonym: "sucrose synthetase activity" EXACT [EC:2.4.1.13]
synonym: "sucrose-UDP glucosyltransferase activity" EXACT [EC:2.4.1.13]
synonym: "sucrose-uridine diphosphate glucosyltransferase activity" EXACT [EC:2.4.1.13]
synonym: "UDP-glucose-fructose glucosyltransferase activity" EXACT [EC:2.4.1.13]
synonym: "UDPglucose-fructose glucosyltransferase activity" EXACT [EC:2.4.1.13]
synonym: "uridine diphosphoglucose-fructose glucosyltransferase activity" EXACT [EC:2.4.1.13]
xref: EC:2.4.1.13
xref: MetaCyc:SUCROSE-SYNTHASE-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0016158
name: 3-phytase activity
namespace: molecular_function
def: "Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate." [EC:3.1.3.8]
subset: gosubset_prok
synonym: "1-phytase activity" EXACT [EC:3.1.3.8]
synonym: "myo-inositol-hexakisphosphate 3-phosphohydrolase activity" EXACT [EC:3.1.3.8]
synonym: "myo-inositol-hexaphosphate 3-phosphohydrolase activity" EXACT []
synonym: "phytase activity" BROAD []
synonym: "phytate 1-phosphatase activity" EXACT [EC:3.1.3.8]
synonym: "phytate 3-phosphatase activity" EXACT []
xref: EC:3.1.3.8
xref: MetaCyc:RXN0-1001
xref: RHEA:16992
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0016159
name: muconolactone delta-isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,5-dihydro-5-oxofuran-2-acetate = 3,4-dihydro-5-oxofuran-2-acetate." [EC:5.3.3.4]
subset: gosubset_prok
synonym: "5-oxo-4,5-dihydrofuran-2-acetate delta3-delta2-isomerase activity" EXACT [EC:5.3.3.4]
synonym: "muconolactone D-isomerase activity" EXACT []
synonym: "muconolactone isomerase activity" EXACT [EC:5.3.3.4]
xref: EC:5.3.3.4
xref: MetaCyc:MUCONOLACTONE-DELTA-ISOMERASE-RXN
xref: RHEA:12351
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0016160
name: amylase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of amylose or an amylose derivative." [GOC:ai]
subset: gosubset_prok
xref: EC:3.2.1.-
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0016161
name: beta-amylase activity
namespace: molecular_function
def: "Catalysis of the reaction: (1,4-alpha-D-glucosyl)(n+1) + H2O = (1,4-alpha-D-glucosyl)(n-1) + alpha-maltose. This reaction is the hydrolysis of 1,4-alpha-glucosidic linkages in polysaccharides so as to remove successive maltose units from the non-reducing ends of the chains." [EC:3.2.1.2]
subset: gosubset_prok
synonym: "1,4-alpha-D-glucan maltohydrolase activity" EXACT [EC:3.2.1.2]
synonym: "beta amylase activity" EXACT [EC:3.2.1.2]
synonym: "glycogenase activity" BROAD [EC:3.2.1.2]
synonym: "saccharogen amylase activity" EXACT [EC:3.2.1.2]
xref: EC:3.2.1.2
xref: MetaCyc:RXN-1827
is_a: GO:0016160 ! amylase activity

[Term]
id: GO:0016162
name: cellulose 1,4-beta-cellobiosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains." [EC:3.2.1.91]
subset: gosubset_prok
synonym: "1,4-beta-cellobiohydrolase activity" EXACT [EC:3.2.1.91]
synonym: "1,4-beta-D-glucan cellobiohydrolase activity" EXACT [EC:3.2.1.91]
synonym: "1,4-beta-glucan cellobiosidase activity" EXACT [EC:3.2.1.91]
synonym: "avicelase activity" BROAD [EC:3.2.1.91]
synonym: "beta-1,4-glucan cellobiohydrolase activity" EXACT [EC:3.2.1.91]
synonym: "beta-1,4-glucan cellobiosylhydrolase activity" EXACT [EC:3.2.1.91]
synonym: "C1 cellulase activity" EXACT [EC:3.2.1.91]
synonym: "CBH 1" RELATED [EC:3.2.1.91]
synonym: "cellobiohydrolase activity" EXACT [EC:3.2.1.91]
synonym: "cellobiohydrolase I" RELATED [EC:3.2.1.91]
synonym: "cellobiosidase activity" EXACT [EC:3.2.1.91]
synonym: "exo-1,4-beta-D-glucanase activity" EXACT [EC:3.2.1.91]
synonym: "exo-beta-1,4-glucan cellobiohydrolase activity" EXACT [EC:3.2.1.91]
synonym: "exo-cellobiohydrolase activity" EXACT [EC:3.2.1.91]
synonym: "exocellobiohydrolase activity" EXACT [EC:3.2.1.91]
synonym: "exoglucanase activity" EXACT [EC:3.2.1.91]
xref: EC:3.2.1.91
xref: MetaCyc:3.2.1.91-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0016163
name: nitrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 8 reduced ferredoxin + 8 H+ + nitrogen + 16 ATP = 8 oxidized ferredoxin + 2 NH3 + 16 ADP + 16 phosphate." [EC:1.18.6.1]
subset: gosubset_prok
synonym: "iron-iron nitrogenase activity" NARROW []
synonym: "molybdenum-iron nitrogenase activity" NARROW []
synonym: "reduced ferredoxin:dinitrogen oxidoreductase (ATP-hydrolysing) activity" EXACT [EC:1.18.6.1]
synonym: "vanadium-iron nitrogenase activity" NARROW []
xref: EC:1.18.6.1
xref: MetaCyc:NITROGENASE-RXN
xref: UM-BBD_enzymeID:e0395
is_a: GO:0016732 ! oxidoreductase activity, acting on iron-sulfur proteins as donors, dinitrogen as acceptor

[Term]
id: GO:0016164
name: obsolete Mo-molybdopterin oxidoreductase activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because the differentia from the parent is a gene product feature (specifically, the presence of a molybdopterin cofactor in the protein). It has also never been defined.
subset: gosubset_prok
synonym: "Mo-molybdopterin oxidoreductase activity" EXACT []
synonym: "molybdopterin oxidoreductase activity" EXACT []
is_obsolete: true
replaced_by: GO:0016491

[Term]
id: GO:0016165
name: linoleate 13S-lipoxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate." [EC:1.13.11.12, GOC:lb]
subset: gosubset_prok
synonym: "carotene oxidase activity" NARROW [EC:1.13.11.12]
synonym: "fat oxidase activity" EXACT [EC:1.13.11.12]
synonym: "linoleate:oxygen 13-oxidoreductase activity" EXACT [EC:1.13.11.12]
synonym: "lionoleate:O2 oxidoreductase activity" EXACT [EC:1.13.11.12]
synonym: "lipoperoxidase activity" EXACT [EC:1.13.11.12]
synonym: "lipoxidase activity" EXACT [EC:1.13.11.12]
synonym: "lipoxydase activity" EXACT [EC:1.13.11.12]
synonym: "lipoxygenase activity" BROAD []
xref: EC:1.13.11.12
xref: MetaCyc:LIPOXYGENASE-RXN
xref: RHEA:22783
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0016166
name: phytoene dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the dehydrogenation of phytoene to produce a carotenoid intermediate such as phytofluene." [http://www.chem.qmul.ac.uk/iubmb/enzyme/reaction/terp/carot.html]
subset: gosubset_prok
xref: EC:1.3.-.-
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0016167
name: glial cell-derived neurotrophic factor receptor activity
namespace: molecular_function
def: "Combining with glial cell line-derived neurotrophic factor and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling]
synonym: "GDNF receptor activity" EXACT [GOC:mah]
synonym: "glial cell line-derived neurotrophic factor receptor activity" EXACT [GOC:bf]
is_a: GO:0004896 ! cytokine receptor activity
relationship: part_of GO:0035860 ! glial cell-derived neurotrophic factor receptor signaling pathway

[Term]
id: GO:0016168
name: chlorophyll binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment." [GOC:jl]
subset: gosubset_prok
is_a: GO:0046906 ! tetrapyrrole binding

[Term]
id: GO:0016169
name: bacteriochlorophyll c binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with bacteriochlorophyll c, a chlorophyll of photosynthetic bacteria, for example green sulfur bacteria." [ISBN:0192800981]
subset: gosubset_prok
is_a: GO:0042314 ! bacteriochlorophyll binding

[Term]
id: GO:0016170
name: interleukin-15 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-15 receptor." [GOC:ai]
synonym: "IL-15" NARROW []
synonym: "interleukin-15 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0016171
name: obsolete cell surface antigen
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity.
synonym: "cell surface antigen" EXACT []
is_obsolete: true

[Term]
id: GO:0016172
name: obsolete antifreeze activity
namespace: molecular_function
def: "OBSOLETE. Inhibits the formation of ice crystals in organismal fluid (e.g. blood) at below freezing exogenous temperatures." [GOC:jl]
comment: This term was made obsolete because it refers to a biological process.
synonym: "antifreeze activity" EXACT []
is_obsolete: true
consider: GO:0042309
consider: GO:0050825
consider: GO:0050826

[Term]
id: GO:0016173
name: obsolete ice nucleation inhibitor activity
namespace: molecular_function
def: "OBSOLETE. Inhibits the formation of ice crystals." [GOC:ai]
comment: This term was made obsolete because it refers to a biological process.
synonym: "ice nucleation inhibitor activity" EXACT []
is_obsolete: true
consider: GO:0042309
consider: GO:0050825
consider: GO:0050826

[Term]
id: GO:0016174
name: NAD(P)H oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(P)H + H+ + O2 = NAD(P)+ + hydrogen peroxide." [EC:1.6.3.1]
synonym: "dual oxidase activity" RELATED [EC:1.6.3.1]
synonym: "NAD(P)H:oxygen oxidoreductase activity" EXACT [EC:1.6.3.1]
synonym: "NADPH oxidase" BROAD [EC:1.6.3.1]
synonym: "p138tox" RELATED [EC:1.6.3.1]
synonym: "ThOX activity" NARROW [EC:1.6.3.1]
synonym: "THOX2 activity" NARROW [EC:1.6.3.1]
synonym: "thyroid NADPH oxidase activity" NARROW []
synonym: "thyroid oxidase 2 activity" NARROW [EC:1.6.3.1]
synonym: "thyroid oxidase activity" NARROW [EC:1.6.3.1]
xref: EC:1.6.3.1
is_a: GO:0050664 ! oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor

[Term]
id: GO:0016175
name: superoxide-generating NADPH oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(P)H + O2 = NAD(P)H + O2-." [GOC:ai, PMID:10806195]
synonym: "cytochrome B-245" RELATED []
xref: EC:1.6.3.-
xref: Reactome:REACT_111243 "Alkalization of the phagosomal lumen by NOX2, Homo sapiens"
xref: Reactome:REACT_111249 "Uncoupled eNOS favours the formation of superoxide, Homo sapiens"
is_a: GO:0050664 ! oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor

[Term]
id: GO:0016176
name: superoxide-generating NADPH oxidase activator activity
namespace: molecular_function
def: "Increases the activity of the enzyme superoxide-generating NADPH oxidase." [GOC:ai]
synonym: "neutrophil cytosol factor 2" NARROW []
is_a: GO:0008047 ! enzyme activator activity
relationship: positively_regulates GO:0016175 ! superoxide-generating NADPH oxidase activity

[Term]
id: GO:0016180
name: snRNA processing
namespace: biological_process
def: "Any process involved in the conversion of a primary small nuclear RNA (snRNA) transcript into a mature snRNA molecule." [GOC:jl]
is_a: GO:0016073 ! snRNA metabolic process
is_a: GO:0034470 ! ncRNA processing

[Term]
id: GO:0016182
name: synaptic vesicle budding from endosome
namespace: biological_process
def: "Budding of synaptic vesicles during the formation of constitutive recycling vesicles from early endosomes." [GOC:curators, PMID:10099709]
subset: goslim_synapse
synonym: "endosome to synaptic vesicle budding" RELATED [GOC:mah]
synonym: "synaptic vesicle budding involved in synaptic vesicle exocytosis" EXACT [GOC:mah]
is_a: GO:0016192 ! vesicle-mediated transport
is_a: GO:0016482 ! cytosolic transport
is_a: GO:0070142 ! synaptic vesicle budding
is_a: GO:1902582 ! single-organism intracellular transport
is_a: GO:1902591 ! single-organism membrane budding
relationship: part_of GO:0036466 ! synaptic vesicle recycling via endosome
relationship: part_of GO:0099532 ! synaptic vesicle processing via endosome

[Term]
id: GO:0016183
name: synaptic vesicle coating
namespace: biological_process
def: "The formation of clathrin coated pits in the presynaptic membrane endocytic zone, triggered by the presence of high concentrations of synaptic vesicle components. This process leads to, but does not include budding of the membrane to form new vesicles." [GOC:curators, PMID:10099709, PMID:20448150]
subset: goslim_synapse
is_a: GO:0006901 ! vesicle coating
relationship: part_of GO:0016185 ! synaptic vesicle budding from presynaptic endocytic zone membrane

[Term]
id: GO:0016184
name: obsolete synaptic vesicle retrieval
namespace: biological_process
def: "OBSOLETE. Return of a vesicle from the postsynaptic membrane to presynaptic membrane." [GOC:curators]
comment: This term was made obsolete because it was wrongly defined.
synonym: "synaptic vesicle retrieval" EXACT []
is_obsolete: true
consider: GO:0016192

[Term]
id: GO:0016185
name: synaptic vesicle budding from presynaptic endocytic zone membrane
namespace: biological_process
def: "Evagination of the presynaptic membrane, resulting in the formation of a new synaptic vesicle." [GOC:curators, PMID:10099709, PMID:20448150]
subset: goslim_synapse
synonym: "synaptic vesicle budding from pre-synaptic membrane" EXACT []
synonym: "synaptic vesicle budding involved in synaptic vesicle endocytosis" EXACT [GOC:mah]
is_a: GO:0070142 ! synaptic vesicle budding
intersection_of: GO:0070142 ! synaptic vesicle budding
intersection_of: part_of GO:0048488 ! synaptic vesicle endocytosis
relationship: part_of GO:0048488 ! synaptic vesicle endocytosis

[Term]
id: GO:0016186
name: obsolete synaptic vesicle fission
namespace: biological_process
def: "OBSOLETE. Separation of a synaptic vesicle from the presynaptic membrane." [GOC:curators]
comment: This term was made obsolete because it was wrongly defined.
synonym: "synaptic vesicle fission" EXACT []
is_obsolete: true
consider: GO:0016192

[Term]
id: GO:0016187
name: obsolete synaptic vesicle internalization
namespace: biological_process
def: "OBSOLETE. Internalization of the contents of a synaptic vesicle into the postsynaptic membrane following endocytosis." [GOC:curators]
comment: This term was made obsolete because it was wrongly defined.
synonym: "synaptic vesicle internalization" EXACT []
is_obsolete: true
consider: GO:0016192

[Term]
id: GO:0016188
name: synaptic vesicle maturation
namespace: biological_process
def: "Steps required to form an initiated synaptic vesicle into a fully formed and transmissible synaptic vesicle." [GOC:curators, PMID:10099709]
is_a: GO:0016050 ! vesicle organization
is_a: GO:0021700 ! developmental maturation
is_a: GO:1902589 ! single-organism organelle organization

[Term]
id: GO:0016189
name: synaptic vesicle to endosome fusion
namespace: biological_process
def: "Fusion of a synaptic vesicle with an endosome." [GOC:curators, PMID:10099709]
comment: This covers fusion of synaptic vesicles trafficked to the synapse as well as fusion of endocytosed vesicles as part of recycling.  It is there for not  part of the synaptic vesicle cycle.
subset: goslim_synapse
is_a: GO:0051469 ! vesicle fusion with vacuole
relationship: part_of GO:0099532 ! synaptic vesicle processing via endosome

[Term]
id: GO:0016191
name: synaptic vesicle uncoating
namespace: biological_process
def: "The removal of the protein coat on a synaptic vesicle following the pinching step at the end of budding from the presynaptic membrane." [GOC:curators, PMID:10099709, PMID:24596248]
subset: goslim_synapse
synonym: "synaptic vesicle coat depolymerization" EXACT []
synonym: "synaptic vesicle coat protein depolymerization" EXACT []
is_a: GO:0072319 ! vesicle uncoating
relationship: part_of GO:0048488 ! synaptic vesicle endocytosis

[Term]
id: GO:0016192
name: vesicle-mediated transport
namespace: biological_process
alt_id: GO:0006899
def: "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_pir
subset: goslim_pombe
subset: gosubset_prok
synonym: "nonselective vesicle transport" NARROW []
synonym: "protein sorting along secretory pathway" RELATED []
synonym: "vesicle trafficking" RELATED []
synonym: "vesicle transport" EXACT []
synonym: "vesicular transport" EXACT [GOC:mah]
is_a: GO:0006810 ! transport

[Term]
id: GO:0016197
name: endosomal transport
namespace: biological_process
def: "The directed movement of substances into, out of, or mediated by an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to lysosomes for degradation." [ISBN:0198506732]
subset: goslim_yeast
synonym: "endosome transport" RELATED [GOC:bf]
xref: Reactome:REACT_27258 "Endosomal Sorting Complex Required For Transport (ESCRT), Homo sapiens"
is_a: GO:0007034 ! vacuolar transport

[Term]
id: GO:0016198
name: axon choice point recognition
namespace: biological_process
def: "The recognition of molecules at a choice point by an axon growth cone; at a choice point the growth cone determines the direction of its future growth." [PMID:10218152]
is_a: GO:0008038 ! neuron recognition
relationship: part_of GO:0007411 ! axon guidance

[Term]
id: GO:0016199
name: axon midline choice point recognition
namespace: biological_process
def: "The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline." [PMID:11376484]
is_a: GO:0016198 ! axon choice point recognition

[Term]
id: GO:0016200
name: synaptic target attraction
namespace: biological_process
def: "The process in which a neuronal cell in a multicellular organism recognizes chemoattractant signals from, and grows towards, potential targets." [GOC:mah, ISBN:0878932437]
is_a: GO:0050918 ! positive chemotaxis
relationship: part_of GO:0008039 ! synaptic target recognition

[Term]
id: GO:0016201
name: synaptic target inhibition
namespace: biological_process
def: "The process in which a neuronal cell in a multicellular organism recognizes chemorepellent signals that inhibit its growth toward the source." [GOC:mah, ISBN:0878932437]
is_a: GO:0050919 ! negative chemotaxis
relationship: part_of GO:0008039 ! synaptic target recognition

[Term]
id: GO:0016202
name: regulation of striated muscle tissue development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of striated muscle development." [GOC:go_curators]
is_a: GO:0048634 ! regulation of muscle organ development
is_a: GO:1901861 ! regulation of muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0014706 ! striated muscle tissue development
relationship: regulates GO:0014706 ! striated muscle tissue development

[Term]
id: GO:0016203
name: muscle attachment
namespace: biological_process
def: "The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall)." [GOC:isa_complete, GOC:sart]
is_a: GO:0044707 ! single-multicellular organism process
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0060538 ! skeletal muscle organ development

[Term]
id: GO:0016204
name: determination of muscle attachment site
namespace: biological_process
def: "The process that mediates the transfer of information from the cells of a muscle to those of its intended target, thereby identifying the target site." [GOC:isa_complete]
is_a: GO:0007267 ! cell-cell signaling
relationship: part_of GO:0016203 ! muscle attachment

[Term]
id: GO:0016205
name: selenocysteine methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: selenocysteine + S-adenosyl-L-methionine = Se-methylselenocysteine + S-adenosyl-homocysteine." [EC:2.1.1.-, PMID:10026151]
xref: EC:2.1.1.-
is_a: GO:0051995 ! Se-methyltransferase activity

[Term]
id: GO:0016206
name: catechol O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol." [EC:2.1.1.6]
subset: gosubset_prok
synonym: "catechol methyltransferase activity" EXACT [EC:2.1.1.6]
synonym: "catecholamine O-methyltransferase activity" EXACT [EC:2.1.1.6]
synonym: "COMT I" RELATED [EC:2.1.1.6]
synonym: "COMT II" RELATED [EC:2.1.1.6]
synonym: "MB-COMT (membrane-bound form of catechol-O-methyltransferase)" RELATED [EC:2.1.1.6]
synonym: "S-adenosyl-L-methionine:catechol O-methyltransferase activity" EXACT [EC:2.1.1.6]
synonym: "S-COMT (soluble form of catechol-O-methyltransferase)" RELATED [EC:2.1.1.6]
xref: EC:2.1.1.6
xref: MetaCyc:CATECHOL-O-METHYLTRANSFERASE-RXN
xref: Reactome:REACT_101180 "3,4-dihydroxybenzoate can be O-methylated, Mycobacterium tuberculosis"
xref: Reactome:REACT_106126 "3,4-dihydroxybenzoate can be O-methylated, Taeniopygia guttata"
xref: Reactome:REACT_107035 "3,4-dihydroxybenzoate can be O-methylated, Mus musculus"
xref: Reactome:REACT_107702 "3,4-dihydroxybenzoate can be O-methylated, Canis familiaris"
xref: Reactome:REACT_108398 "3,4-dihydroxybenzoate can be O-methylated, Rattus norvegicus"
xref: Reactome:REACT_110868 "3,4-dihydroxybenzoate can be O-methylated, Schizosaccharomyces pombe"
xref: Reactome:REACT_29223 "3,4-dihydroxybenzoate can be O-methylated, Bos taurus"
xref: Reactome:REACT_29723 "3,4-dihydroxybenzoate can be O-methylated, Xenopus tropicalis"
xref: Reactome:REACT_6885 "3,4-dihydroxybenzoate can be O-methylated, Homo sapiens"
xref: Reactome:REACT_79706 "3,4-dihydroxybenzoate can be O-methylated, Gallus gallus"
xref: Reactome:REACT_80595 "3,4-dihydroxybenzoate can be O-methylated, Sus scrofa"
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0016207
name: 4-coumarate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA." [EC:6.2.1.12]
subset: gosubset_prok
synonym: "4-coumarate-CoA synthetase activity" EXACT []
synonym: "4-coumarate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.12]
synonym: "4-coumarate:CoA ligase activity" EXACT []
synonym: "4-coumarate:coenzyme A ligase activity" EXACT [EC:6.2.1.12]
synonym: "4-coumaroyl-CoA synthase activity" EXACT [EC:6.2.1.12]
synonym: "4-coumaroyl-CoA synthetase activity" EXACT [EC:6.2.1.12]
synonym: "4-coumaryl-CoA synthetase activity" EXACT [EC:6.2.1.12]
synonym: "4CL" RELATED [EC:6.2.1.12]
synonym: "caffeolyl coenzyme A synthetase activity" EXACT [EC:6.2.1.12]
synonym: "feruloyl CoA ligase activity" EXACT [EC:6.2.1.12]
synonym: "feruloyl coenzyme A synthetase activity" EXACT [EC:6.2.1.12]
synonym: "hydroxycinnamate:CoA ligase activity" EXACT [EC:6.2.1.12]
synonym: "hydroxycinnamoyl CoA synthetase activity" EXACT [EC:6.2.1.12]
synonym: "p-coumaroyl CoA ligase activity" EXACT [EC:6.2.1.12]
synonym: "p-coumaryl coenzyme A synthetase activity" EXACT [EC:6.2.1.12]
synonym: "p-coumaryl-CoA ligase activity" EXACT [EC:6.2.1.12]
synonym: "p-coumaryl-CoA synthetase activity" EXACT [EC:6.2.1.12]
synonym: "p-hydroxycinnamic acid:CoA ligase activity" EXACT [EC:6.2.1.12]
synonym: "p-hydroxycinnamoyl coenzyme A synthetase activity" EXACT [EC:6.2.1.12]
synonym: "sinapoyl coenzyme A synthetase activity" EXACT [EC:6.2.1.12]
xref: EC:6.2.1.12
xref: KEGG:R01616
xref: MetaCyc:4-COUMARATE--COA-LIGASE-RXN
xref: RHEA:19644
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0016208
name: AMP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with AMP, adenosine monophosphate." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0032550 ! purine ribonucleoside binding
is_a: GO:0032559 ! adenyl ribonucleotide binding
is_a: GO:0043168 ! anion binding
is_a: GO:0043169 ! cation binding

[Term]
id: GO:0016209
name: antioxidant activity
namespace: molecular_function
def: "Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage." [ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0003674 ! molecular_function
relationship: part_of GO:0098869 ! cellular oxidant detoxification

[Term]
id: GO:0016210
name: naringenin-chalcone synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2." [EC:2.3.1.74]
subset: gosubset_prok
synonym: "chalcone synthase activity" EXACT [EC:2.3.1.74]
synonym: "chalcone synthetase activity" EXACT []
synonym: "CHS" EXACT []
synonym: "DOCS" NARROW []
synonym: "flavanone synthase activity" EXACT [EC:2.3.1.74]
synonym: "flavonone synthase activity" EXACT [EC:2.3.1.74]
synonym: "malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)" BROAD [EC:2.3.1.74]
xref: EC:2.3.1.74
xref: MetaCyc:NARINGENIN-CHALCONE-SYNTHASE-RXN
xref: RHEA:11131
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0016211
name: ammonia ligase activity
namespace: molecular_function
def: "Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:jl]
subset: gosubset_prok
xref: EC:6.3.1.-
is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity

[Term]
id: GO:0016212
name: kynurenine-oxoglutarate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate." [EC:2.6.1.7]
subset: gosubset_prok
synonym: "kynurenine 2-oxoglutarate transaminase activity" EXACT [EC:2.6.1.7]
synonym: "kynurenine aminotransferase activity" BROAD [EC:2.6.1.7]
synonym: "kynurenine transaminase (cyclizing)" EXACT [EC:2.6.1.7]
synonym: "kynurenine--oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.7]
synonym: "kynurenine-oxoglutarate aminotransferase activity" EXACT []
synonym: "L-kynurenine aminotransferase activity" EXACT [EC:2.6.1.7]
synonym: "L-kynurenine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.7]
xref: EC:2.6.1.7
xref: MetaCyc:2.6.1.7-RXN
xref: Reactome:REACT_25131 "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate, Homo sapiens"
xref: Reactome:REACT_25310 "kynurenine + pyruvate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + alanine [CCBL2], Homo sapiens"
xref: Reactome:REACT_25349 "kynurenine + pyruvate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + alanine [CCBL1], Homo sapiens"
xref: RHEA:20967
is_a: GO:0036137 ! kynurenine aminotransferase activity

[Term]
id: GO:0016213
name: linoleoyl-CoA desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: linoleoyl-CoA + reduced acceptor + O2 = gamma-linolenoyl-CoA + acceptor + 2 H2O." [EC:1.14.19.3]
comment: Note that this function was formerly EC:1.14.99.25.
subset: gosubset_prok
synonym: "delta(6)-acyl CoA desaturase activity" BROAD []
synonym: "delta(6)-desaturase activity" BROAD []
synonym: "delta(6)-fatty acyl-CoA desaturase activity" BROAD []
synonym: "delta6-acyl CoA desaturase activity" EXACT [EC:1.14.19.3]
synonym: "delta6-desaturase activity" EXACT [EC:1.14.19.3]
synonym: "delta6-fatty acyl-CoA desaturase activity" EXACT [EC:1.14.19.3]
synonym: "fatty acid 6-desaturase activity" BROAD []
synonym: "fatty acid delta(6)-desaturase activity" BROAD []
synonym: "fatty acid delta6-desaturase activity" EXACT [EC:1.14.19.3]
synonym: "linoleate desaturase activity" RELATED []
synonym: "linoleic acid desaturase activity" RELATED []
synonym: "linoleic desaturase activity" RELATED []
synonym: "linoleoyl CoA desaturase activity" EXACT []
synonym: "linoleoyl-CoA,hydrogen-donor:oxygen oxidoreductase activity" EXACT [EC:1.14.19.3]
synonym: "linoleoyl-coenzyme A desaturase activity" EXACT []
synonym: "long-chain fatty acid delta(6)-desaturase activity" BROAD []
synonym: "long-chain fatty acid delta6-desaturase activity" EXACT [EC:1.14.19.3]
xref: EC:1.14.19.3
xref: MetaCyc:1.14.19.3-RXN
xref: RHEA:22199
is_a: GO:0016215 ! acyl-CoA desaturase activity

[Term]
id: GO:0016215
name: acyl-CoA desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + reduced acceptor + O2 = desaturated-acyl-CoA + acceptor + 2 H2O." [EC:1.14.19.1, EC:1.14.19.5, GOC:mah]
subset: gosubset_prok
synonym: "CoA desaturase activity" BROAD []
xref: EC:1.14.19.-
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

[Term]
id: GO:0016216
name: isopenicillin-N synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O(2) = 2 H(2)O + isopenicillin N." [EC:1.21.3.1, RHEA:22431]
subset: gosubset_prok
synonym: "isopenicillin N synthase activity" EXACT [EC:1.21.3.1]
synonym: "isopenicillin-N synthetase activity" EXACT []
synonym: "N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine:oxygen oxidoreductase (cyclizing)" EXACT [EC:1.21.3.1]
xref: EC:1.21.3.1
xref: KEGG:R04872
xref: MetaCyc:1.21.3.1-RXN
xref: RHEA:22431
is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor

[Term]
id: GO:0016217
name: N-ethylammeline chlorohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: deethylsimazine + H2O = N-ethylammeline + chloride + H+." [MetaCyc:R465-RXN]
xref: MetaCyc:R465-RXN
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0016218
name: obsolete polyketide synthase activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:curators]
comment: This term was made obsolete because the activity it describes does not exist, and the gene product with the name 'polyketide synthase' has multiple functional domains, so using the name to describe a single function would be misleading.
synonym: "polyketide synthase activity" EXACT []
is_obsolete: true
replaced_by: GO:0030639
consider: GO:0034081

[Term]
id: GO:0016222
name: procollagen-proline 4-dioxygenase complex
namespace: cellular_component
def: "A protein complex that catalyzes the formation of procollagen trans-4-hydroxy-L-proline and succinate from procollagen L-proline and 2-oxoglutarate, requiring Fe2+ and ascorbate. Contains two alpha subunits that contribute to most parts of the catalytic sites, and two beta subunits that are identical to protein-disulfide isomerase." [PMID:14500733, PMID:7753822]
synonym: "procollagen-proline, 2-oxoglutarate-4-dioxygenase complex" EXACT [EC:1.14.11.2]
synonym: "prolyl 4-hydroxylase complex" BROAD [EC:1.14.11.2]
is_a: GO:0044432 ! endoplasmic reticulum part
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:0016223
name: beta-alanine-pyruvate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-alanine + 2-oxopropanoate = pyruvate + beta-alanine." [EC:2.6.1.18]
subset: gosubset_prok
synonym: "beta-alanine--pyruvate aminotransferase activity" EXACT [EC:2.6.1.18]
synonym: "beta-alanine-alpha-alanine transaminase activity" EXACT [EC:2.6.1.18]
synonym: "beta-alanine-pyruvate aminotransferase activity" EXACT []
synonym: "L-alanine:3-oxopropanoate aminotransferase activity" EXACT [EC:2.6.1.18]
synonym: "omega-amino acid--pyruvate aminotransferase activity" EXACT [EC:2.6.1.18]
xref: EC:2.6.1.18
xref: MetaCyc:2.6.1.18-RXN
xref: Reactome:REACT_25226 "beta-alanine + pyruvate => 3-oxopropanoate + alanine, Homo sapiens"
xref: Reactome:REACT_25239 "beta-alanine + pyruvate => 3-oxopropanoate + alanine, Rattus norvegicus"
xref: RHEA:14080
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0016226
name: iron-sulfur cluster assembly
namespace: biological_process
def: "The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster." [GOC:jl, GOC:mah, GOC:pde, GOC:vw]
subset: goslim_pombe
subset: gosubset_prok
synonym: "iron-sulfur cluster biosynthesis" RELATED []
synonym: "iron-sulphur cluster assembly" EXACT []
is_a: GO:0031163 ! metallo-sulfur cluster assembly
is_a: GO:0051188 ! cofactor biosynthetic process

[Term]
id: GO:0016227
name: obsolete tRNA sulfurtransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: L-cysteine + 'activated' tRNA = L-serine + tRNA containing a thionucleotide." [EC:2.8.1.4]
comment: This term was made obsolete because tRNA thionucleotide formation is a multistep process; there is no single reaction in which cysteine reacts with an activated tRNA directly
synonym: "L-cysteine:tRNA sulfurtransferase activity" EXACT [EC:2.8.1.4]
synonym: "ribonucleate sulfurtransferase activity" EXACT [EC:2.8.1.4]
synonym: "RNA sulfurtransferase activity" EXACT [EC:2.8.1.4]
synonym: "transfer ribonucleate sulfurtransferase activity" EXACT [EC:2.8.1.4]
synonym: "transfer RNA sulfurtransferase activity" EXACT [EC:2.8.1.4]
synonym: "transfer RNA thiolase activity" EXACT [EC:2.8.1.4]
synonym: "tRNA sulfurtransferase activity" EXACT []
synonym: "tRNA sulphurtransferase activity" EXACT []
xref: EC:2.8.1.4
xref: MetaCyc:TRNA-S-TRANSFERASE-RXN
is_obsolete: true
replaced_by: GO:0034227
consider: GO:0016783

[Term]
id: GO:0016229
name: steroid dehydrogenase activity
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which one substrate is a sterol derivative." [GOC:mah]
subset: gosubset_prok
xref: EC:1.1.1.-
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016230
name: sphingomyelin phosphodiesterase activator activity
namespace: molecular_function
def: "Increases the activity of the enzyme sphingomyelin phosphodiesterase." [GOC:ai]
synonym: "neutral sphingomyelinase activator" EXACT []
is_a: GO:0016004 ! phospholipase activator activity
relationship: positively_regulates GO:0004767 ! sphingomyelin phosphodiesterase activity

[Term]
id: GO:0016231
name: beta-N-acetylglucosaminidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-beta-D-glucosaminides." [EC:3.2.1.52, MetaCyc:3.2.1.52-RXN]
is_a: GO:0004563 ! beta-N-acetylhexosaminidase activity

[Term]
id: GO:0016232
name: HNK-1 sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the synthesis of the HKK-1 carbohydrate epitope; adds a sulfate group to a precursor, GlcA-beta-(1->3)-Gal-beta-(1->4)-GlcNAc-beta-(1->R), forming sulfo-3GlcA-beta-(1->3)-Gal-beta-(1->4)-GlcNAc-beta-(1->R)." [PMID:9478973]
synonym: "HNK-1 sulphotransferase activity" EXACT []
xref: EC:2.8.2.-
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0016233
name: telomere capping
namespace: biological_process
def: "A process in which telomeres are protected from degradation and fusion, thereby ensuring chromosome stability by protecting the ends from both degradation and from being recognized as damaged DNA. May be mediated by specific single- or double-stranded telomeric DNA binding proteins." [GOC:mah, GOC:rn, PMID:11349150, PMID:11352055]
synonym: "telomere end protection" EXACT []
xref: Reactome:REACT_105479 "Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure, Mus musculus"
xref: Reactome:REACT_105591 "Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure, Rattus norvegicus"
xref: Reactome:REACT_107496 "Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure, Sus scrofa"
xref: Reactome:REACT_112263 "Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure, Danio rerio"
xref: Reactome:REACT_113641 "Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure, Canis familiaris"
xref: Reactome:REACT_114938 "Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure, Danio rerio"
xref: Reactome:REACT_115404 "Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure, Canis familiaris"
xref: Reactome:REACT_77047 "Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure, Sus scrofa"
xref: Reactome:REACT_77776 "Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure, Rattus norvegicus"
xref: Reactome:REACT_7971 "Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure, Homo sapiens"
xref: Reactome:REACT_8031 "Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure, Homo sapiens"
xref: Reactome:REACT_92417 "Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure, Mus musculus"
is_a: GO:0000723 ! telomere maintenance

[Term]
id: GO:0016234
name: inclusion body
namespace: cellular_component
def: "A discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers." [GOC:mah, PMID:11121744]
synonym: "cellular inclusion" RELATED [NIF_Subcellular:sao120573470]
synonym: "neuronal cytoplasmic inclusion" NARROW []
xref: NIF_Subcellular:sao120573470
xref: Wikipedia:Inclusion_bodies
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0016235
name: aggresome
namespace: cellular_component
def: "An inclusion body formed by dynein-dependent retrograde transport of an aggregated protein on microtubules." [PMID:11121744]
xref: Wikipedia:Aggresome
is_a: GO:0016234 ! inclusion body

[Term]
id: GO:0016236
name: macroautophagy
namespace: biological_process
alt_id: GO:0034262
def: "The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure.  Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Though once thought to be a purely non-selective process, it appears that some types of macroautophagy, e.g. macropexophagy, macromitophagy, may involve selective targeting of the targets to be degraded." [PMID:11099404, PMID:12914914, PMID:15798367, PMID:16973210, PMID:20159618, PMID:9412464]
comment: Targeted macroautophagy sometimes targets regions of cytoplasm containing non-self, such as virus particles or components (e.g. see PMID:20159618).  As this is essentially the same process as macroautophagy that encloses and digests only self, the term autophagy is still used despite the enclosure of some non-self (non-auto) entities.
synonym: "autophagy" BROAD []
synonym: "autophagy in response to cellular starvation" EXACT []
synonym: "non-specific autophagy" EXACT []
synonym: "starvation-induced autophagy" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0006914 ! autophagy
intersection_of: GO:0006914 ! autophagy
intersection_of: has_part GO:1905037 ! autophagosome organization
relationship: has_part GO:1905037 ! autophagosome organization

[Term]
id: GO:0016237
name: lysosomal microautophagy
namespace: biological_process
def: "The transfer of cytosolic components into the lysosomal compartment by direct invagination of the lysosomal membrane without prior sequestration into an autophagosome. The engulfing membranes fuse, resulting in the lysosomal delivery of the cargo wrapped in a single membrane derived from the invaginated lysosomal membrane. In S. cerevisiae, the vacuole is the lysosomal compartment." [PMID:14679207, PMID:15798367, PMID:16973210, PMID:9566964]
is_a: GO:0006914 ! autophagy
is_a: GO:0044712 ! single-organism catabolic process
is_a: GO:1902534 ! single-organism membrane invagination

[Term]
id: GO:0016239
name: positive regulation of macroautophagy
namespace: biological_process
def: "Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation." [GOC:go_curators, PMID:9412464]
synonym: "activation of macroautophagy" NARROW []
synonym: "positive regulation of starvation-induced autophagy" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "stimulation of macroautophagy" NARROW []
synonym: "up regulation of macroautophagy" EXACT []
synonym: "up-regulation of macroautophagy" EXACT []
synonym: "upregulation of macroautophagy" EXACT []
is_a: GO:0010508 ! positive regulation of autophagy
is_a: GO:0010647 ! positive regulation of cell communication
is_a: GO:0016241 ! regulation of macroautophagy
is_a: GO:0032109 ! positive regulation of response to nutrient levels
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016236 ! macroautophagy
relationship: positively_regulates GO:0016236 ! macroautophagy

[Term]
id: GO:0016240
name: autophagosome docking
namespace: biological_process
def: "The initial attachment of an autophagosome membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere." [GOC:autophagy, GOC:mah]
synonym: "autophagic vacuole docking" EXACT [GOC:autophagy]
is_a: GO:0022406 ! membrane docking
is_a: GO:1902589 ! single-organism organelle organization
is_a: GO:1905037 ! autophagosome organization

[Term]
id: GO:0016241
name: regulation of macroautophagy
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of macroautophagy." [GOC:krc]
synonym: "regulation of starvation-induced autophagy" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0010506 ! regulation of autophagy
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0032107 ! regulation of response to nutrient levels
is_a: GO:0080135 ! regulation of cellular response to stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016236 ! macroautophagy
relationship: regulates GO:0016236 ! macroautophagy

[Term]
id: GO:0016242
name: negative regulation of macroautophagy
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy." [GOC:go_curators]
synonym: "down regulation of macroautophagy" EXACT []
synonym: "down-regulation of macroautophagy" EXACT []
synonym: "downregulation of macroautophagy" EXACT []
synonym: "inhibition of macroautophagy" NARROW []
synonym: "negative regulation of starvation-induced autophagy" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0010507 ! negative regulation of autophagy
is_a: GO:0010648 ! negative regulation of cell communication
is_a: GO:0016241 ! regulation of macroautophagy
is_a: GO:0032108 ! negative regulation of response to nutrient levels
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016236 ! macroautophagy
relationship: negatively_regulates GO:0016236 ! macroautophagy

[Term]
id: GO:0016243
name: regulation of autophagosome size
namespace: biological_process
def: "Any process that modulates the size of the autophagosome." [GOC:autophagy, GOC:krc]
synonym: "regulation of autophagic vacuole size" EXACT [GOC:autophagy]
is_a: GO:0032535 ! regulation of cellular component size
relationship: part_of GO:0016236 ! macroautophagy

[Term]
id: GO:0016246
name: RNA interference
namespace: biological_process
def: "The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes." [GOC:ems, PMID:11201747, PMID:11713190, PMID:18771919]
comment: Note that this term refers specifically to posttranscriptional mechanisms by which small interfering RNAs down-regulate gene expression. Also consider annotating to other descendants of 'gene silencing by RNA ; GO:0031047'.
synonym: "posttranscriptional gene silencing by siRNA" EXACT [GOC:mah]
synonym: "RNAi" EXACT []
xref: Wikipedia:RNA_interference
is_a: GO:0035194 ! posttranscriptional gene silencing by RNA

[Term]
id: GO:0016247
name: channel regulator activity
namespace: molecular_function
def: "Modulates the activity of a channel. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel." [GOC:mah]
subset: gosubset_prok
is_a: GO:0098772 ! molecular function regulator
relationship: regulates GO:0015267 ! channel activity

[Term]
id: GO:0016248
name: channel inhibitor activity
namespace: molecular_function
def: "Stops, prevents, or reduces the activity of a channel. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel." [GOC:mah]
subset: gosubset_prok
is_a: GO:0016247 ! channel regulator activity
relationship: negatively_regulates GO:0015267 ! channel activity

[Term]
id: GO:0016250
name: N-sulfoglucosamine sulfohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate." [EC:3.10.1.1]
synonym: "2-desoxy-D-glucoside-2-sulphamate sulphohydrolase (sulphamate sulphohydrolase)" EXACT [EC:3.10.1.1]
synonym: "heparin sulfamidase activity" EXACT [EC:3.10.1.1]
synonym: "N-sulfo-D-glucosamine sulfohydrolase activity" EXACT [EC:3.10.1.1]
synonym: "N-sulphoglucosamine sulphohydrolase activity" EXACT []
synonym: "sulfoglucosamine sulfamidase activity" EXACT [EC:3.10.1.1]
synonym: "sulphamidase activity" EXACT [EC:3.10.1.1]
xref: EC:3.10.1.1
xref: MetaCyc:N-SULFOGLUCOSAMINE-SULFOHYDROLASE-RXN
xref: RHEA:17884
is_a: GO:0016826 ! hydrolase activity, acting on acid sulfur-nitrogen bonds

[Term]
id: GO:0016251
name: obsolete general RNA polymerase II transcription factor activity
namespace: molecular_function
alt_id: GO:0003703
def: "OBSOLETE. Any function that supports basal (unregulated) transcription of genes by core RNA polymerase II. Five general transcription factors are necessary and sufficient for such basal transcription in yeast: TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBF)." [PMID:10384286, PMID:9774831]
comment: This term was obsoleted because "general/nonspecific/basal" transcription vs "specific" transcription were determined not to be separable, distinct process. Thus, terms trying to distinguish "general/nonspecific/basal" transcription from "specific" transcription were removed from both the Molecular Function and the Biological Process ontologies. In addition, this Molecular Function term was defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
synonym: "general RNA polymerase II transcription factor activity" EXACT []
is_obsolete: true
consider: GO:0000981
consider: GO:0000991
consider: GO:0001076
consider: GO:0006366

[Term]
id: GO:0016252
name: obsolete nonspecific RNA polymerase II transcription factor activity
namespace: molecular_function
def: "OBSOLETE. Any function that supports transcription of genes by RNA polymerase II, and is not specific to a particular gene or gene set." [GOC:jl]
comment: This term was obsoleted because "general/nonspecific/basal" transcription vs "specific" transcription were determined not to be separable, distinct process. Thus, terms trying to distinguish "general/nonspecific/basal" transcription from "specific" transcription were removed from both the Molecular Function and the Biological Process ontologies. In addition, this Molecular Function term was defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
synonym: "nonspecific RNA polymerase II transcription factor activity" EXACT []
is_obsolete: true
consider: GO:0000981
consider: GO:0000991
consider: GO:0001076
consider: GO:0006366

[Term]
id: GO:0016254
name: preassembly of GPI anchor in ER membrane
namespace: biological_process
def: "The stepwise addition of the components of the GPI anchor on to phosphatidylinositol lipids in the endoplasmic reticulum membrane." [ISBN:0879695595]
subset: gosubset_prok
synonym: "preassembly of GPI anchor in endoplasmic reticulum membrane" EXACT []
xref: Reactome:REACT_100927 "Synthesis of glycosylphosphatidylinositol (GPI), Plasmodium falciparum"
xref: Reactome:REACT_105683 "Synthesis of glycosylphosphatidylinositol (GPI), Oryza sativa"
xref: Reactome:REACT_107180 "Synthesis of glycosylphosphatidylinositol (GPI), Rattus norvegicus"
xref: Reactome:REACT_31719 "Synthesis of glycosylphosphatidylinositol (GPI), Drosophila melanogaster"
xref: Reactome:REACT_32903 "Synthesis of glycosylphosphatidylinositol (GPI), Schizosaccharomyces pombe"
xref: Reactome:REACT_77325 "Synthesis of glycosylphosphatidylinositol (GPI), Bos taurus"
xref: Reactome:REACT_78045 "Synthesis of glycosylphosphatidylinositol (GPI), Caenorhabditis elegans"
xref: Reactome:REACT_79154 "Synthesis of glycosylphosphatidylinositol (GPI), Saccharomyces cerevisiae"
xref: Reactome:REACT_82911 "Synthesis of glycosylphosphatidylinositol (GPI), Dictyostelium discoideum"
xref: Reactome:REACT_83560 "Synthesis of glycosylphosphatidylinositol (GPI), Danio rerio"
xref: Reactome:REACT_83626 "Synthesis of glycosylphosphatidylinositol (GPI), Sus scrofa"
xref: Reactome:REACT_88178 "Synthesis of glycosylphosphatidylinositol (GPI), Arabidopsis thaliana"
xref: Reactome:REACT_93950 "Synthesis of glycosylphosphatidylinositol (GPI), Canis familiaris"
xref: Reactome:REACT_94288 "Synthesis of glycosylphosphatidylinositol (GPI), Mus musculus"
xref: Reactome:REACT_952 "Synthesis of glycosylphosphatidylinositol (GPI), Homo sapiens"
xref: Reactome:REACT_95916 "Synthesis of glycosylphosphatidylinositol (GPI), Taeniopygia guttata"
xref: Reactome:REACT_96702 "Synthesis of glycosylphosphatidylinositol (GPI), Gallus gallus"
xref: Reactome:REACT_97430 "Synthesis of glycosylphosphatidylinositol (GPI), Xenopus tropicalis"
is_a: GO:0006650 ! glycerophospholipid metabolic process
relationship: part_of GO:0006506 ! GPI anchor biosynthetic process

[Term]
id: GO:0016255
name: attachment of GPI anchor to protein
namespace: biological_process
def: "A transamidation reaction that results in the cleavage of the polypeptide chain and the concomitant transfer of the GPI anchor to the newly formed carboxy-terminal amino acid of the anchored protein. The cleaved C-terminal contains the C-terminal GPI signal sequence of the newly synthesized polypeptide chain." [ISBN:0879695595]
subset: gosubset_prok
xref: Reactome:REACT_101840 "Attachment of GPI anchor to uPAR, Rattus norvegicus"
xref: Reactome:REACT_105004 "Attachment of GPI anchor to uPAR, Bos taurus"
xref: Reactome:REACT_110848 "Attachment of GPI anchor to uPAR, Danio rerio"
xref: Reactome:REACT_112166 "Attachment of GPI anchor to uPAR, Xenopus tropicalis"
xref: Reactome:REACT_1830 "Attachment of GPI anchor to uPAR, Homo sapiens"
xref: Reactome:REACT_31102 "Attachment of GPI anchor to uPAR, Sus scrofa"
xref: Reactome:REACT_85671 "Attachment of GPI anchor to uPAR, Mus musculus"
xref: Reactome:REACT_87909 "Attachment of GPI anchor to uPAR, Canis familiaris"
is_a: GO:0006464 ! cellular protein modification process
relationship: part_of GO:0006506 ! GPI anchor biosynthetic process

[Term]
id: GO:0016256
name: N-glycan processing to lysosome
namespace: biological_process
def: "The modification of high-mannose N-glycans by UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase and the subsequent removal of the N-acetylglucosamine residues yielding mannose-6-P that occurs in the ER-Golgi apparatus to N-glycans destined for the lysosome." [ISBN:0879695595]
is_a: GO:0006491 ! N-glycan processing
intersection_of: GO:0006491 ! N-glycan processing
intersection_of: part_of GO:0006622 ! protein targeting to lysosome
relationship: part_of GO:0006622 ! protein targeting to lysosome

[Term]
id: GO:0016257
name: N-glycan processing to secreted and cell-surface N-glycans
namespace: biological_process
def: "The modification of high-mannose (Man9-Asn) N-glycans by mannosyl-oligosaccharide 1,2-alpha-mannosidase. This may result in Man8GlcNAc2-Asn N-glycans (which in yeast may be subsequently modified by the addition of further mannose residues) or Man5GlcNAc2-Asn N-glycans that are substrates for further diversification in the Golgi apparatus." [ISBN:0879695595]
subset: gosubset_prok
is_a: GO:0006491 ! N-glycan processing

[Term]
id: GO:0016258
name: N-glycan diversification
namespace: biological_process
def: "The generation, in the Golgi apparatus, of side chain diversity from high mannose Man5GlcNAc2-Asn N-glycans by specific glycosyltransferases and glycosidases." [ISBN:0879695595]
subset: gosubset_prok
is_a: GO:0006491 ! N-glycan processing

[Term]
id: GO:0016259
name: selenocysteine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving selenocysteine, an essential component of glutathione peroxidase and some other proteins." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "selenocysteine metabolism" EXACT []
is_a: GO:0001887 ! selenium compound metabolic process
is_a: GO:0006575 ! cellular modified amino acid metabolic process
is_a: GO:0009069 ! serine family amino acid metabolic process

[Term]
id: GO:0016260
name: selenocysteine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of selenocysteine, an essential component of glutathione peroxidase and some other proteins." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "selenocysteine anabolism" EXACT []
synonym: "selenocysteine biosynthesis" EXACT []
synonym: "selenocysteine formation" EXACT []
synonym: "selenocysteine synthesis" EXACT []
is_a: GO:0009070 ! serine family amino acid biosynthetic process
is_a: GO:0016259 ! selenocysteine metabolic process
is_a: GO:0042398 ! cellular modified amino acid biosynthetic process

[Term]
id: GO:0016261
name: selenocysteine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of selenocysteine, an essential component of glutathione peroxidase and some other proteins." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "selenocysteine breakdown" EXACT []
synonym: "selenocysteine catabolism" EXACT []
synonym: "selenocysteine degradation" EXACT []
is_a: GO:0009071 ! serine family amino acid catabolic process
is_a: GO:0016259 ! selenocysteine metabolic process
is_a: GO:0042219 ! cellular modified amino acid catabolic process

[Term]
id: GO:0016262
name: protein N-acetylglucosaminyltransferase activity
namespace: molecular_function
alt_id: GO:0016253
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + protein = UDP + 4-N-(N-acetyl-D-glucosaminyl)-protein." [EC:2.4.1.94]
synonym: "N-GlcNAc transferase activity" EXACT [EC:2.4.1.94]
synonym: "UDP-N-acetyl-D-glucosamine:protein beta-N-acetyl-D-glucosaminyl-transferase activity" EXACT []
synonym: "UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase activity" EXACT []
synonym: "uridine diphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyltransferase activity" EXACT []
synonym: "uridine diphosphoacetylglucosamine-protein acetylglucosaminyltransferase activity" EXACT []
xref: EC:2.4.1.94
xref: MetaCyc:2.4.1.94-RXN
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0016263
name: glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the addition of a galactosyl residue to a non-reducing O-linked N-acetylgalactosamine residue in an O-glycan." [EC:2.4.1.122, GOC:ma]
synonym: "Core 1 GalT" RELATED []
synonym: "UDP-galactose:glycoprotein-N-acetyl-D-galactosamine 3-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.122]
synonym: "UDPgalactose:glycoprotein-N-acetyl-D-galactosamine 3-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.122]
synonym: "uridine diphosphogalactose-mucin beta-(1->3)-galactosyltransferase activity" EXACT [EC:2.4.1.122]
xref: EC:2.4.1.122
xref: MetaCyc:2.4.1.122-RXN
xref: Reactome:REACT_116072 "C1GALT1 transfers galactose to the Tn antigen forming Core 1 glycoproteins (T antigens), Homo sapiens"
is_a: GO:0048531 ! beta-1,3-galactosyltransferase activity

[Term]
id: GO:0016264
name: gap junction assembly
namespace: biological_process
def: "Assembly of gap junctions, which are found in most animal tissues, and serve as direct connections between the cytoplasms of adjacent cells. They provide open channels through the plasma membrane, allowing ions and small molecules (less than approximately a thousand daltons) to diffuse freely between neighboring cells, but preventing the passage of proteins and nucleic acids." [GOC:jid, ISBN:0716731363]
xref: Reactome:REACT_29613 "Gap junction assembly, Taeniopygia guttata"
xref: Reactome:REACT_30378 "Gap junction assembly, Canis familiaris"
xref: Reactome:REACT_31045 "Gap junction assembly, Danio rerio"
xref: Reactome:REACT_32552 "Gap junction assembly, Bos taurus"
xref: Reactome:REACT_34150 "Gap junction assembly, Sus scrofa"
xref: Reactome:REACT_90349 "Gap junction assembly, Xenopus tropicalis"
xref: Reactome:REACT_94763 "Gap junction assembly, Mus musculus"
xref: Reactome:REACT_9509 "Gap junction assembly, Homo sapiens"
xref: Reactome:REACT_95307 "Gap junction assembly, Gallus gallus"
xref: Reactome:REACT_98454 "Gap junction assembly, Rattus norvegicus"
is_a: GO:0007043 ! cell-cell junction assembly

[Term]
id: GO:0016265
name: obsolete death
namespace: biological_process
def: "OBSOLETE. A permanent cessation of all vital functions: the end of life; can be applied to a whole organism or to a part of an organism." [GOC:mah, GOC:mtg_apoptosis, ISBN:0877797099]
comment: This term was made obsolete because it refers to a phenotype. When death of a cell or tissue is a result of a true biological process, this should be captured using 'programmed cell death' or one of its descendants.
xref: Wikipedia:Death
is_obsolete: true
consider: GO:0008219
consider: GO:0012501

[Term]
id: GO:0016266
name: O-glycan processing
namespace: biological_process
def: "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form a core O-glycan structure." [GOC:mah, GOC:pr, PMID:10580130]
subset: gosubset_prok
xref: Reactome:REACT_115606 "O-linked glycosylation of mucins, Homo sapiens"
xref: Reactome:REACT_115835 "Termination of O-glycan biosynthesis, Homo sapiens"
is_a: GO:0006493 ! protein O-linked glycosylation

[Term]
id: GO:0016267
name: O-glycan processing, core 1
namespace: biological_process
def: "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 1 O-glycan structure, Gal-beta-(1->3)-GalNAc." [GOC:mah, GOC:pr, PMID:10580130]
subset: gosubset_prok
is_a: GO:0016266 ! O-glycan processing

[Term]
id: GO:0016268
name: O-glycan processing, core 2
namespace: biological_process
def: "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 2 O-glycan structure, GlcNAc-beta-(1->6)[Gal-beta-(1->3)]-GalNAc." [GOC:mah, GOC:pr, PMID:10580130]
subset: gosubset_prok
is_a: GO:0016266 ! O-glycan processing

[Term]
id: GO:0016269
name: O-glycan processing, core 3
namespace: biological_process
def: "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 3 O-glycan structure, GlcNAc-beta-(1->3)-GalNAc." [GOC:mah, GOC:pr, PMID:10580130]
subset: gosubset_prok
is_a: GO:0016266 ! O-glycan processing

[Term]
id: GO:0016270
name: O-glycan processing, core 4
namespace: biological_process
def: "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 4 O-glycan structure, GlcNAc-beta-(1->6)[GalNAc-beta-(1->3)]-GalNAc." [GOC:mah, GOC:pr, PMID:10580130]
subset: gosubset_prok
is_a: GO:0016266 ! O-glycan processing

[Term]
id: GO:0016271
name: obsolete tissue death
namespace: biological_process
def: "OBSOLETE. A permanent cessation of all vital functions of a tissue." [GOC:dph, GOC:mtg_apoptosis]
comment: This term was made obsolete because it refers to a phenotype. When death of a cell or tissue is a result of a true biological process, this should be captured using 'programmed cell death' or one of its descendants.
is_obsolete: true
consider: GO:0008219
consider: GO:0012501

[Term]
id: GO:0016272
name: prefoldin complex
namespace: cellular_component
def: "A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics." [GOC:jl, PMID:17384227, PMID:24068951, PMID:9630229]
subset: gosubset_prok
synonym: "GIM complex" NARROW []
xref: Wikipedia:Prefoldin
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0016273
name: arginine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to an amino group of an arginine residue." [GOC:mah]
xref: EC:2.1.1.-
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0016274
name: protein-arginine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + (protein)-arginine = S-adenosyl-L-homocysteine + (protein)-N-methyl-arginine." [EC:2.1.1.125, EC:2.1.1.126, GOC:mah, PMID:12351636]
synonym: "PRMT activity" EXACT []
xref: EC:2.1.1.-
xref: Reactome:REACT_10041 "Loading and methylation of Sm proteins onto SMN Complexes, Homo sapiens"
xref: Reactome:REACT_109502 "Loading and methylation of Sm proteins onto SMN Complexes, Danio rerio"
xref: Reactome:REACT_112455 "Loading and methylation of Sm proteins onto SMN Complexes, Xenopus tropicalis"
xref: Reactome:REACT_81235 "Loading and methylation of Sm proteins onto SMN Complexes, Mus musculus"
is_a: GO:0008276 ! protein methyltransferase activity
is_a: GO:0016273 ! arginine N-methyltransferase activity
relationship: part_of GO:0035246 ! peptidyl-arginine N-methylation

[Term]
id: GO:0016275
name: [cytochrome c]-arginine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + (cytochrome c)-arginine = S-adenosyl-L-homocysteine + (cytochrome c)-N(omega)-methyl-arginine." [EC:2.1.1.124, GOC:ma]
synonym: "cytochrome c-arginine N-methyltransferase activity" EXACT [EC:2.1.1.124]
synonym: "S-adenosyl-L-methionine:cytochrome c-arginine nomega-methyltransferasea" RELATED [EC:2.1.1.124]
synonym: "S-adenosyl-L-methionine:cytochrome c-arginine omega-N-methyltransferasea" RELATED [EC:2.1.1.124]
xref: EC:2.1.1.124
xref: MetaCyc:2.1.1.124-RXN
is_a: GO:0016274 ! protein-arginine N-methyltransferase activity

[Term]
id: GO:0016277
name: [myelin basic protein]-arginine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + (myelin basic protein)-arginine = S-adenosyl-L-homocysteine + (myelin basic protein)-N(omega)-methyl-arginine." [EC:2.1.1.126]
synonym: "myelin basic protein methylase activity" EXACT [EC:2.1.1.126]
synonym: "myelin basic protein methylase I" RELATED [EC:2.1.1.126]
synonym: "myelin basic protein-arginine N-methyltransferase activity" EXACT [EC:2.1.1.126]
synonym: "protein methylase I activity" BROAD [EC:2.1.1.126]
synonym: "S-adenosyl-L-methionine:myelin-basic-protein-arginine nomega-methyltransferase activity" EXACT [EC:2.1.1.126]
synonym: "S-adenosyl-L-methionine:myelin-basic-protein-arginine omega-N-methyltransferase activity" EXACT [EC:2.1.1.126]
xref: EC:2.1.1.126
xref: MetaCyc:2.1.1.126-RXN
is_a: GO:0016274 ! protein-arginine N-methyltransferase activity

[Term]
id: GO:0016278
name: lysine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue." [GOC:mah]
subset: gosubset_prok
xref: EC:2.1.1.-
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0016279
name: protein-lysine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate." [PMID:12054878]
subset: gosubset_prok
xref: EC:2.1.1.-
is_a: GO:0008276 ! protein methyltransferase activity
is_a: GO:0016278 ! lysine N-methyltransferase activity
relationship: part_of GO:0018022 ! peptidyl-lysine methylation

[Term]
id: GO:0016281
name: eukaryotic translation initiation factor 4F complex
namespace: cellular_component
def: "The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome." [GOC:hb, PMID:8449919]
synonym: "eIF-4F" EXACT []
synonym: "eukaryotic translation initiation factor 4 complex" BROAD []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0016282
name: eukaryotic 43S preinitiation complex
namespace: cellular_component
def: "A protein complex composed of the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound methionyl-initiator methionine tRNA." [GOC:hjd, PMID:15145049]
synonym: "eukaryotic 43S pre-initiation complex" EXACT []
is_a: GO:0070993 ! translation preinitiation complex
relationship: has_part GO:0022627 ! cytosolic small ribosomal subunit

[Term]
id: GO:0016284
name: obsolete alanine aminopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of an N-terminal amino acid, preferentially alanine, from an oligopeptide or polypeptide." [GOC:jl]
comment: This term was made obsolete because it represents a gene product, and the substrate specificity it refers to is not cleanly defined.
subset: gosubset_prok
synonym: "alanine aminopeptidase activity" EXACT []
xref: EC:3.4.11.-
is_obsolete: true
consider: GO:0004177
consider: GO:0008235

[Term]
id: GO:0016285
name: obsolete cytosol alanyl aminopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of an N-terminal amino acid, preferentially alanine, from a wide range of peptides, amides and arylamides." [EC:3.4.11.14]
comment: This term was made obsolete because it represents a gene product and refers to cellular component information.
subset: gosubset_prok
synonym: "aminopolypeptidase activity" EXACT [EC:3.4.11.14]
synonym: "arylamidase activity" NARROW [EC:3.4.11.14]
synonym: "cytosol alanyl aminopeptidase activity" EXACT []
synonym: "cytosol aminopeptidase III activity" NARROW [EC:3.4.11.14]
synonym: "human liver aminopeptidase" NARROW [EC:3.4.11.14]
synonym: "liver aminopeptidase activity" NARROW [EC:3.4.11.14]
synonym: "puromycin-sensitive aminopeptidase activity" NARROW [EC:3.4.11.14]
synonym: "soluble alanyl aminopeptidase activity" EXACT [EC:3.4.11.14]
synonym: "thiol-activated aminopeptidase activity" EXACT [EC:3.4.11.14]
xref: EC:3.4.11.14
xref: MetaCyc:3.4.11.14-RXN
is_obsolete: true
consider: GO:0004177
consider: GO:0008235

[Term]
id: GO:0016286
name: small conductance calcium-activated potassium channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of potassium by a channel with a unit conductance of 2 to 20 picoSiemens that opens in response to stimulus by internal calcium ions. Small conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, OMIM:602754]
synonym: "SK calcium-activated potassium channel activity" EXACT []
synonym: "SK KCa channels" EXACT []
synonym: "small conductance KCa channels" EXACT []
is_a: GO:0015269 ! calcium-activated potassium channel activity

[Term]
id: GO:0016287
name: glycerone-phosphate O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + glycerone phosphate = 1-acylglycerone 3-phosphate + CoA." [EC:2.3.1.42, RHEA:17660]
synonym: "acyl-CoA:glycerone-phosphate O-acyltransferase activity" EXACT [EC:2.3.1.42]
synonym: "dihydroxyacetone phosphate acyltransferase activity" EXACT [EC:2.3.1.42]
xref: EC:2.3.1.42
xref: KEGG:R01013
xref: MetaCyc:2.3.1.42-RXN
xref: Reactome:REACT_101107 "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH, Gallus gallus"
xref: Reactome:REACT_104676 "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH, Rattus norvegicus"
xref: Reactome:REACT_104779 "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH, Bos taurus"
xref: Reactome:REACT_114425 "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH, Mycobacterium tuberculosis"
xref: Reactome:REACT_114844 "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH, Escherichia coli"
xref: Reactome:REACT_15 "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH, Homo sapiens"
xref: Reactome:REACT_28493 "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH, Dictyostelium discoideum"
xref: Reactome:REACT_31288 "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH, Drosophila melanogaster"
xref: Reactome:REACT_33327 "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH, Danio rerio"
xref: Reactome:REACT_86795 "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH, Canis familiaris"
xref: Reactome:REACT_86845 "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH, Caenorhabditis elegans"
xref: Reactome:REACT_91097 "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH, Taeniopygia guttata"
xref: Reactome:REACT_94392 "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH, Sus scrofa"
xref: Reactome:REACT_96075 "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH, Mus musculus"
xref: Reactome:REACT_96215 "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH, Xenopus tropicalis"
xref: RHEA:17660
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0016289
name: CoA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: X-CoA + H2O = X + CoA; X may be any group." [GOC:ai]
subset: gosubset_prok
xref: EC:3.1.2.-
xref: Reactome:REACT_10061 "Hydrolysis of choloyl-CoA to cholate and CoASH, Homo sapiens"
xref: Reactome:REACT_102201 "Hydrolysis of choloyl-CoA to cholate and CoASH, Canis familiaris"
xref: Reactome:REACT_102489 "Hydrolysis of choloyl-CoA to cholate and CoASH, Gallus gallus"
xref: Reactome:REACT_104967 "Hydrolysis of choloyl-CoA to cholate and CoASH, Taeniopygia guttata"
xref: Reactome:REACT_107841 "Hydrolysis of choloyl-CoA to cholate and CoASH, Sus scrofa"
xref: Reactome:REACT_110860 "Hydrolysis of choloyl-CoA to cholate and CoASH, Oryza sativa"
xref: Reactome:REACT_29514 "Hydrolysis of choloyl-CoA to cholate and CoASH, Danio rerio"
xref: Reactome:REACT_31738 "Hydrolysis of choloyl-CoA to cholate and CoASH, Mycobacterium tuberculosis"
xref: Reactome:REACT_33802 "Hydrolysis of choloyl-CoA to cholate and CoASH, Rattus norvegicus"
xref: Reactome:REACT_39336 "Hydrolysis of choloyl-CoA to cholate and CoASH, Mus musculus"
xref: Reactome:REACT_78636 "Hydrolysis of choloyl-CoA to cholate and CoASH, Xenopus tropicalis"
xref: Reactome:REACT_80492 "Hydrolysis of choloyl-CoA to cholate and CoASH, Saccharomyces cerevisiae"
xref: Reactome:REACT_82264 "Hydrolysis of choloyl-CoA to cholate and CoASH, Caenorhabditis elegans"
xref: Reactome:REACT_84921 "Hydrolysis of choloyl-CoA to cholate and CoASH, Arabidopsis thaliana"
xref: Reactome:REACT_91936 "Hydrolysis of choloyl-CoA to cholate and CoASH, Bos taurus"
xref: Reactome:REACT_99363 "Hydrolysis of choloyl-CoA to cholate and CoASH, Escherichia coli"
is_a: GO:0016790 ! thiolester hydrolase activity

[Term]
id: GO:0016290
name: palmitoyl-CoA hydrolase activity
namespace: molecular_function
alt_id: GO:0016293
def: "Catalysis of the reaction: palmitoyl-CoA + H2O = CoA + palmitate." [EC:3.1.2.2]
subset: goslim_chembl
subset: gosubset_prok
synonym: "fatty acyl thioesterase I" RELATED [EC:3.1.2.2]
synonym: "long-chain fatty-acyl-CoA hydrolase activity" BROAD []
synonym: "palmitoyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.2]
synonym: "palmitoyl thioesterase activity" EXACT [EC:3.1.2.2]
synonym: "palmitoyl-CoA deacylase activity" EXACT [EC:3.1.2.2]
synonym: "palmityl thioesterase activity" EXACT [EC:3.1.2.2]
synonym: "palmityl thioesterase I" RELATED [EC:3.1.2.2]
synonym: "palmityl-CoA deacylase activity" EXACT [EC:3.1.2.2]
xref: EC:3.1.2.2
xref: MetaCyc:PALMITOYL-COA-HYDROLASE-RXN
xref: MetaCyc:PWY-5148
xref: RHEA:16648
is_a: GO:0047617 ! acyl-CoA hydrolase activity

[Term]
id: GO:0016295
name: myristoyl-[acyl-carrier-protein] hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: myristoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + myristate." [EC:3.1.2.14, MetaCyc:RXN-10727]
synonym: "myristoyl-[acyl-carrier protein] hydrolase activity" EXACT []
synonym: "myristoyl-ACP hydrolase activity" EXACT []
synonym: "tetradecanoyl-[acyl-carrier-protein] hydrolase activity" EXACT []
synonym: "tetradecanoyl-ACP hydrolase activity" EXACT []
xref: EC:3.1.2.14
xref: KEGG:R08159
xref: MetaCyc:RXN-10727
is_a: GO:0016297 ! acyl-[acyl-carrier-protein] hydrolase activity

[Term]
id: GO:0016296
name: palmitoyl-[acyl-carrier-protein] hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: palmitoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + palmitate." [EC:3.1.2.14, MetaCyc:RXN-9549]
synonym: "palmitoyl-[acyl-carrier protein] hydrolase activity" EXACT []
synonym: "palmitoyl-ACP hydrolase activity" EXACT []
xref: EC:3.1.2.14
xref: KEGG:R08162
xref: MetaCyc:RXN-9549
is_a: GO:0016297 ! acyl-[acyl-carrier-protein] hydrolase activity

[Term]
id: GO:0016297
name: acyl-[acyl-carrier-protein] hydrolase activity
namespace: molecular_function
alt_id: GO:0010281
def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + a fatty acid." [EC:3.1.2.14, MetaCyc:RXN-7902]
subset: gosubset_prok
synonym: "acyl-[acyl-carrier protein] hydrolase activity" EXACT []
synonym: "acyl-ACP hydrolase activity" EXACT []
synonym: "acyl-ACP thioesterase activity" EXACT []
synonym: "acyl-ACP-hydrolase activity" EXACT [EC:3.1.2.14]
synonym: "acyl-acyl carrier protein hydrolase activity" EXACT [EC:3.1.2.14]
synonym: "acyl-acyl-carrier-protein hydrolase activity" EXACT [EC:3.1.2.14]
synonym: "S-acyl fatty acid synthase thioesterase activity" EXACT [EC:3.1.2.14]
xref: EC:3.1.2.14
xref: MetaCyc:RXN-7902
is_a: GO:0004312 ! fatty acid synthase activity
is_a: GO:0016790 ! thiolester hydrolase activity

[Term]
id: GO:0016298
name: lipase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah]
subset: goslim_aspergillus
subset: goslim_chembl
subset: goslim_metagenomics
subset: gosubset_prok
xref: EC:3.1.1.-
xref: Reactome:REACT_100499 "cholesterol ester + H2O -> cholesterol + fatty acid, Mus musculus"
xref: Reactome:REACT_112065 "diacylglycerol + H2O -> 2-acylglycerol + fatty acid, Danio rerio"
xref: Reactome:REACT_114396 "cholesterol ester + H2O -> cholesterol + fatty acid, Danio rerio"
xref: Reactome:REACT_1867 "cholesterol ester + H2O -> cholesterol + fatty acid, Rattus norvegicus"
xref: Reactome:REACT_413 "diacylglycerol + H2O -> 2-acylglycerol + fatty acid, Rattus norvegicus"
xref: Reactome:REACT_731 "diacylglycerol + H2O -> 2-acylglycerol + fatty acid, Homo sapiens"
xref: Reactome:REACT_764 "cholesterol ester + H2O -> cholesterol + fatty acid, Homo sapiens"
xref: Reactome:REACT_81298 "diacylglycerol + H2O -> 2-acylglycerol + fatty acid, Caenorhabditis elegans"
xref: Reactome:REACT_85531 "diacylglycerol + H2O -> 2-acylglycerol + fatty acid, Mus musculus"
xref: Reactome:REACT_87294 "cholesterol ester + H2O -> cholesterol + fatty acid, Canis familiaris"
xref: Reactome:REACT_90239 "cholesterol ester + H2O -> cholesterol + fatty acid, Bos taurus"
xref: Reactome:REACT_91590 "diacylglycerol + H2O -> 2-acylglycerol + fatty acid, Bos taurus"
xref: Reactome:REACT_94613 "diacylglycerol + H2O -> 2-acylglycerol + fatty acid, Canis familiaris"
xref: Reactome:REACT_95662 "diacylglycerol + H2O -> 2-acylglycerol + fatty acid, Xenopus tropicalis"
xref: Reactome:REACT_96515 "cholesterol ester + H2O -> cholesterol + fatty acid, Xenopus tropicalis"
xref: Reactome:REACT_97125 "cholesterol ester + H2O -> cholesterol + fatty acid, Caenorhabditis elegans"
is_a: GO:0016788 ! hydrolase activity, acting on ester bonds

[Term]
id: GO:0016299
name: obsolete regulator of G-protein signaling activity
namespace: molecular_function
def: "OBSOLETE. Inhibits signal transduction the GTPase activity of G-protein alpha subunits, thereby driving them into their inactive GDP-bound form." [GOC:curators]
comment: This term was made obsolete because it refers to a combination of a function and a process.
synonym: "regulator of G protein signaling activity" EXACT []
synonym: "regulator of G protein signalling activity" EXACT []
synonym: "regulator of G-protein signaling activity" EXACT []
synonym: "regulator of G-protein signalling activity" EXACT []
synonym: "RGS" EXACT []
is_obsolete: true
consider: GO:0005095
consider: GO:0034260
consider: GO:0045744

[Term]
id: GO:0016300
name: tRNA (uracil) methyltransferase activity
namespace: molecular_function
alt_id: GO:0016431
def: "Catalysis of the transfer of a methyl group from a donor to a uracil residue in a tRNA molecule." [GOC:mah]
comment: Note that the methyl donor is usually S-adenosyl-L-methionine, but there is at least one exception (see GO:0030698).
subset: gosubset_prok
synonym: "tRNA (uridine) methyltransferase activity" EXACT []
xref: EC:2.1.1.-
is_a: GO:0008175 ! tRNA methyltransferase activity

[Term]
id: GO:0016301
name: kinase activity
namespace: molecular_function
def: "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
comment: Note that this term encompasses all activities that transfer a single phosphate group; although ATP is by far the most common phosphate donor, reactions using other phosphate donors are included in this term.
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "phosphokinase activity" EXACT []
xref: Reactome:REACT_100073 "Activation of S6K1, Schizosaccharomyces pombe"
xref: Reactome:REACT_100078 "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes, Canis familiaris"
xref: Reactome:REACT_100159 "Inactivation of Myt1 kinase, Mus musculus"
xref: Reactome:REACT_100260 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Taeniopygia guttata"
xref: Reactome:REACT_100298 "Phosphorylation of L1 by CK-II, Rattus norvegicus"
xref: Reactome:REACT_100305 "Regulation of NUDC by phosphorylation, Caenorhabditis elegans"
xref: Reactome:REACT_100311 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Canis familiaris"
xref: Reactome:REACT_100390 "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3, Canis familiaris"
xref: Reactome:REACT_100465 "Phosphorylation and inactivation of eEF2K by activated S6K1, Dictyostelium discoideum"
xref: Reactome:REACT_100495 "Cdc6 protein is phosphorylated by CDK, Xenopus tropicalis"
xref: Reactome:REACT_100519 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Bos taurus"
xref: Reactome:REACT_100636 "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2, Canis familiaris"
xref: Reactome:REACT_100637 "Phosphorylation of the Scc1:Cohesion Complex, Mus musculus"
xref: Reactome:REACT_101024 "Phosphorylation and inactivation of eEF2K by activated S6K1, Bos taurus"
xref: Reactome:REACT_101170 "Phosphorylation of APC component of the destruction complex, Drosophila melanogaster"
xref: Reactome:REACT_101303 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Mus musculus"
xref: Reactome:REACT_101431 "Mcm2-7 is phosphorylated by DDK, Danio rerio"
xref: Reactome:REACT_101543 "CAK-mediated phosphorylation of Cyclin E:Cdk2, Canis familiaris"
xref: Reactome:REACT_101596 "Phosphorylation of Cyclin D:Cdk4/6 complexes, Canis familiaris"
xref: Reactome:REACT_101638 "Phosphorylation and activation of CHK2 by ATM, Bos taurus"
xref: Reactome:REACT_101667 "Down Regulation of Emi1 through Phosphorylation of Emi1, Bos taurus"
xref: Reactome:REACT_101841 "Phosphorylation of Cdc25C at Ser216, Rattus norvegicus"
xref: Reactome:REACT_101862 "Myt-1 mediated phosphorylation of Cyclin A:Cdc2, Xenopus tropicalis"
xref: Reactome:REACT_101914 "Wee1- mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes, Xenopus tropicalis"
xref: Reactome:REACT_102090 "Phosphoryation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3, Taeniopygia guttata"
xref: Reactome:REACT_102093 "Phosphorylation and activation of eIF4G by activated S6K1, Danio rerio"
xref: Reactome:REACT_102154 "Autophosphorylation of PAK-2p34 in the activation loop, Schizosaccharomyces pombe"
xref: Reactome:REACT_102322 "RAF1 phosphorylates MEK2, Danio rerio"
xref: Reactome:REACT_102330 "Phosphorylation of MDM2 at serine-395 by ATM kinase, Xenopus tropicalis"
xref: Reactome:REACT_102380 "Regulation of KIF23 (MKLP1) by phosphorylation, Xenopus tropicalis"
xref: Reactome:REACT_102475 "Inactivation of Myt1 kinase, Rattus norvegicus"
xref: Reactome:REACT_102499 "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes, Canis familiaris"
xref: Reactome:REACT_102552 "Phosphorylation of Cdc25A at Ser-123 in response to DNA damage, Canis familiaris"
xref: Reactome:REACT_102607 "Phosphorylation of Cdc25A at Ser-123 in response to DNA damage, Drosophila melanogaster"
xref: Reactome:REACT_102711 "Phosphorylation of L1 by CK-II, Caenorhabditis elegans"
xref: Reactome:REACT_102729 "RAF1 phosphorylates MEK1, Xenopus tropicalis"
xref: Reactome:REACT_102817 "Phosphorylation of L1 by ERK, Mus musculus"
xref: Reactome:REACT_102887 "Mcm2-7 is phosphorylated by DDK, Rattus norvegicus"
xref: Reactome:REACT_102908 "Phosphorylation of the Scc1:Cohesion Complex, Rattus norvegicus"
xref: Reactome:REACT_102915 "Activation of S6K1, Arabidopsis thaliana"
xref: Reactome:REACT_103060 "Phosphorylation of MDC1/NFBD1 by ATM (within 2 c-term BRCT domains), Arabidopsis thaliana"
xref: Reactome:REACT_103291 "Phosphorylation of complexed TSC2 by PKB, Drosophila melanogaster"
xref: Reactome:REACT_103327 "Phosphorylation of Cyclin E2:Cdk2 complexes by Myt1, Rattus norvegicus"
xref: Reactome:REACT_103359 "Wee1- mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes, Danio rerio"
xref: Reactome:REACT_103468 "Activation of Cdc25C, Drosophila melanogaster"
xref: Reactome:REACT_103691 "Phosphorylation of COP1 at Ser-387 by ATM, Xenopus tropicalis"
xref: Reactome:REACT_103727 "Phosphorylation of NBS1 by ATM, Drosophila melanogaster"
xref: Reactome:REACT_103804 "Phosphorylation of AKT2 by PDK1, Canis familiaris"
xref: Reactome:REACT_103989 "Phosphorylation of NBS1 by ATM, Danio rerio"
xref: Reactome:REACT_104022 "Phosphorylation of p53 at ser-15 by ATM kinase, Xenopus tropicalis"
xref: Reactome:REACT_104044 "Phosphorylation and activation of Chk1 by ATM, Sus scrofa"
xref: Reactome:REACT_104109 "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2, Danio rerio"
xref: Reactome:REACT_104209 "Activation of S6K1, Caenorhabditis elegans"
xref: Reactome:REACT_104323 "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes, Rattus norvegicus"
xref: Reactome:REACT_104386 "Phosphorylation and activation of eIF4B by activated S6K1, Bos taurus"
xref: Reactome:REACT_104523 "Inactivation of Wee1 kinase, Bos taurus"
xref: Reactome:REACT_104644 "Regulation of KIF20A (MKL2) by phosphorylation, Bos taurus"
xref: Reactome:REACT_104687 "Phosphorylation of L1 by CK-II, Canis familiaris"
xref: Reactome:REACT_104730 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Schizosaccharomyces pombe"
xref: Reactome:REACT_104822 "Phosphorylation of COP1 at Ser-387 by ATM, Rattus norvegicus"
xref: Reactome:REACT_104837 "SOS phosphorylation and dissociation (SHC), Mus musculus"
xref: Reactome:REACT_104878 "Phosphorylation of Cyclin E:Cdk2 complexes by Wee-1, Xenopus tropicalis"
xref: Reactome:REACT_105254 "Phosphorylation of Cyclin E:Cdk2 complexes by Wee-1, Danio rerio"
xref: Reactome:REACT_105274 "Regulation of KIF20A (MKL2) by phosphorylation, Danio rerio"
xref: Reactome:REACT_105345 "Phosphoryation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3, Drosophila melanogaster"
xref: Reactome:REACT_105373 "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3, Gallus gallus"
xref: Reactome:REACT_105503 "Phosphorylation of L1 by ERK, Bos taurus"
xref: Reactome:REACT_105561 "Phosphorylation of complexed TSC2 by PKB, Xenopus tropicalis"
xref: Reactome:REACT_105569 "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes, Xenopus tropicalis"
xref: Reactome:REACT_105589 "Phosphorylation of p53 at ser-15 by ATM kinase, Canis familiaris"
xref: Reactome:REACT_105664 "Akt1 phosphorylates BAD protein, Rattus norvegicus"
xref: Reactome:REACT_105700 "Phosphorylation of PDE3B, Rattus norvegicus"
xref: Reactome:REACT_105971 "Phosphorylation of Cyclin A:Cdk2 at Tyr 15, Xenopus tropicalis"
xref: Reactome:REACT_105976 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Xenopus tropicalis"
xref: Reactome:REACT_106075 "Akt1 phosphorylates BAD protein, Canis familiaris"
xref: Reactome:REACT_106144 "Phosphorylation of Cyclin E1:Cdk2 complexes by Myt1, Xenopus tropicalis"
xref: Reactome:REACT_106159 "Wee1- mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes, Canis familiaris"
xref: Reactome:REACT_106186 "Phosphorylation of TSC2 by PKB, Drosophila melanogaster"
xref: Reactome:REACT_106225 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Canis familiaris"
xref: Reactome:REACT_1063 "Phosphorylation of Wee1 kinase by Chk1, Schizosaccharomyces pombe"
xref: Reactome:REACT_106324 "Activation of Cdc25C, Mus musculus"
xref: Reactome:REACT_106383 "Phosphorylation of L1 by ERK, Xenopus tropicalis"
xref: Reactome:REACT_106411 "Phosphorylation and inactivation of eEF2K by activated S6K1, Gallus gallus"
xref: Reactome:REACT_106420 "Regulation of KIF23 (MKLP1) by phosphorylation, Taeniopygia guttata"
xref: Reactome:REACT_106500 "Phosphorylation of Cdc25A at Ser-123 by Chk2, Drosophila melanogaster"
xref: Reactome:REACT_106505 "Phosphorylation of histone H2AX at Serine-139 by ATM at the site of DSB, Rattus norvegicus"
xref: Reactome:REACT_106514 "Phosphorylation of NBS1 by ATM, Mus musculus"
xref: Reactome:REACT_106567 "CAK-mediated phosphorylation of Cyclin E:Cdk2, Mus musculus"
xref: Reactome:REACT_106599 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Xenopus tropicalis"
xref: Reactome:REACT_106681 "Phosphorylation of Cyclin A:Cdk2 at Tyr 15, Rattus norvegicus"
xref: Reactome:REACT_106722 "CAK-mediated phosphorylation of Cyclin E:Cdk2, Xenopus tropicalis"
xref: Reactome:REACT_106738 "SOS phosphorylation and dissociation (IRS, Crk), Canis familiaris"
xref: Reactome:REACT_106897 "CAK-mediated phosphorylation of Cyclin E:Cdk2, Danio rerio"
xref: Reactome:REACT_107009 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Arabidopsis thaliana"
xref: Reactome:REACT_107055 "Phosphorylation of Cdc25C at Ser216, Bos taurus"
xref: Reactome:REACT_107102 "SOS phosphorylation and dissociation (IRS, Crk), Danio rerio"
xref: Reactome:REACT_107243 "Phosphorylation of APC component of the destruction complex, Mus musculus"
xref: Reactome:REACT_107247 "Phosphorylation of TSC2 by PKB, Mus musculus"
xref: Reactome:REACT_107310 "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes, Danio rerio"
xref: Reactome:REACT_107424 "Inactivation of Myt1 kinase, Canis familiaris"
xref: Reactome:REACT_107623 "Phosphorylation of histone H2AX at Serine-139 by ATM at the site of DSB, Mus musculus"
xref: Reactome:REACT_107685 "Phosphorylation of Cyclin E:Cdk2 complexes by Wee-1, Sus scrofa"
xref: Reactome:REACT_107732 "Phosphorylation of the Emi1 DSGxxS degron by Plk1, Danio rerio"
xref: Reactome:REACT_107736 "Phosphorylation of Cdc25C at Ser216, Sus scrofa"
xref: Reactome:REACT_107787 "Phosphorylation and activation of CHK2 by ATM, Drosophila melanogaster"
xref: Reactome:REACT_107849 "Phosphorylation of DLC2 by MAPK-8, Bos taurus"
xref: Reactome:REACT_107854 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta, Canis familiaris"
xref: Reactome:REACT_108002 "Plk1-mediated phosphorylation of Nlp, Bos taurus"
xref: Reactome:REACT_108096 "Phosphorylation of beta-catenin at Ser45 by CK1 alpha, Rattus norvegicus"
xref: Reactome:REACT_108132 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Gallus gallus"
xref: Reactome:REACT_108362 "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2, Mus musculus"
xref: Reactome:REACT_108394 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Danio rerio"
xref: Reactome:REACT_108520 "Phosphorylation and activation of Chk1 by ATM, Danio rerio"
xref: Reactome:REACT_108578 "Inactivation of Myt1 kinase, Xenopus tropicalis"
xref: Reactome:REACT_108776 "Free APC/C phosphorylated by Plk1, Taeniopygia guttata"
xref: Reactome:REACT_108840 "Phosphorylation of beta-catenin at Ser45 by CK1 alpha, Canis familiaris"
xref: Reactome:REACT_108871 "Free APC/C phosphorylated by Plk1, Mus musculus"
xref: Reactome:REACT_108971 "Phosphorylation of Cyclin B1 in the CRS domain, Xenopus tropicalis"
xref: Reactome:REACT_108985 "Phosphorylation of cPLA2 by ERK-2, Gallus gallus"
xref: Reactome:REACT_109045 "Phosphorylation of Cyclin E1:Cdk2 complexes by Myt1, Danio rerio"
xref: Reactome:REACT_109065 "Phosphorylation of Cdc25A at Ser-123 by Chk2, Taeniopygia guttata"
xref: Reactome:REACT_109117 "Phosphorylation of 4E-BP1 by activated mTORC1, Dictyostelium discoideum"
xref: Reactome:REACT_109197 "SOS phosphorylation and dissociation (IRS), Mus musculus"
xref: Reactome:REACT_109244 "Inactivation of Myt1 kinase, Schizosaccharomyces pombe"
xref: Reactome:REACT_109260 "Free APC/C phosphorylated by Plk1, Xenopus tropicalis"
xref: Reactome:REACT_109264 "SOS phosphorylation and dissociation (IRS), Canis familiaris"
xref: Reactome:REACT_109331 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Drosophila melanogaster"
xref: Reactome:REACT_109367 "Phosphorylation of APC component of the destruction complex, Gallus gallus"
xref: Reactome:REACT_109549 "Regulation of KIF20A (MKL2) by phosphorylation, Xenopus tropicalis"
xref: Reactome:REACT_109641 "CAK-mediated phosphorylation of Cyclin A:Cdk2, Sus scrofa"
xref: Reactome:REACT_109769 "Free APC/C phosphorylated by Plk1, Gallus gallus"
xref: Reactome:REACT_109799 "Phosphorylation of Cyclin E:Cdk2 complexes by Wee-1, Mus musculus"
xref: Reactome:REACT_110175 "Phosphorylation of MDC1/NFBD1 by ATM (within 2 c-term BRCT domains), Mus musculus"
xref: Reactome:REACT_110254 "Phosphorylation of APC component of the destruction complex, Rattus norvegicus"
xref: Reactome:REACT_110296 "Phosphorylation and activation of Chk1 by ATM, Schizosaccharomyces pombe"
xref: Reactome:REACT_110351 "Phosphorylation and inactivation of eEF2K by activated S6K1, Canis familiaris"
xref: Reactome:REACT_110382 "Phosphorylation of MDC1/NFBD1 by ATM (within 2 c-term BRCT domains), Oryza sativa"
xref: Reactome:REACT_110530 "Down Regulation of Emi1 through Phosphorylation of Emi1, Mus musculus"
xref: Reactome:REACT_110583 "Phosphorylation of DLC2 by MAPK-8, Mus musculus"
xref: Reactome:REACT_110643 "Mcm2-7 is phosphorylated by DDK, Xenopus tropicalis"
xref: Reactome:REACT_110679 "Phosphorylation of histone H2AX at Serine-139 by ATM at the site of DSB, Danio rerio"
xref: Reactome:REACT_110774 "Inactivation of Myt1 kinase, Drosophila melanogaster"
xref: Reactome:REACT_110775 "Phosphorylation of Cdc25A at Ser-123 in response to DNA damage, Rattus norvegicus"
xref: Reactome:REACT_110947 "Regulation of KIF23 (MKLP1) by phosphorylation, Drosophila melanogaster"
xref: Reactome:REACT_110995 "Phosphorylation and activation of eIF4G by activated S6K1, Xenopus tropicalis"
xref: Reactome:REACT_111124 "FGFR associated PI3K phosphorylates PIP2 to PIP3, Homo sapiens"
xref: Reactome:REACT_111171 "FGFR-associated PI3K phosphorylates PIP2 to PIP3, Homo sapiens"
xref: Reactome:REACT_1116 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Homo sapiens"
xref: Reactome:REACT_111930 "Phosphorylation of Cdc25A at Ser-123 by Chk2, Caenorhabditis elegans"
xref: Reactome:REACT_1120 "Regulation of KIF20A (MKL2) by phosphorylation, Homo sapiens"
xref: Reactome:REACT_112075 "Mcm2-7 is phosphorylated by DDK, Drosophila melanogaster"
xref: Reactome:REACT_112101 "Phosphorylation of L1 by CK-II, Xenopus tropicalis"
xref: Reactome:REACT_112156 "Phosphorylation of AKT2 by PDK1, Saccharomyces cerevisiae"
xref: Reactome:REACT_112214 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex, Schizosaccharomyces pombe"
xref: Reactome:REACT_112270 "Akt1 phosphorylates BAD protein, Xenopus tropicalis"
xref: Reactome:REACT_112298 "Autophosphorylation of DNA-PKcs, Dictyostelium discoideum"
xref: Reactome:REACT_112324 "Phosphorylation and activation of eIF4G by activated S6K1, Oryza sativa"
xref: Reactome:REACT_112360 "Regulation of KIF23 (MKLP1) by phosphorylation, Dictyostelium discoideum"
xref: Reactome:REACT_112413 "Phosphorylation of Cdc25A at Ser-123 by Chk2, Saccharomyces cerevisiae"
xref: Reactome:REACT_112480 "Inactivation of Wee1 kinase, Dictyostelium discoideum"
xref: Reactome:REACT_112545 "Phosphorylation and activation of eIF4G by activated S6K1, Drosophila melanogaster"
xref: Reactome:REACT_112633 "CAK-mediated phosphorylation of Cyclin E:Cdk2, Saccharomyces cerevisiae"
xref: Reactome:REACT_112709 "Phosphorylation of L1 by ERK, Saccharomyces cerevisiae"
xref: Reactome:REACT_112722 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex, Drosophila melanogaster"
xref: Reactome:REACT_112790 "Phosphorylation of Cdc25A at Ser-123 in response to DNA damage, Caenorhabditis elegans"
xref: Reactome:REACT_112846 "Phosphorylation of Cyclin E1:Cdk2 complexes by Myt1, Saccharomyces cerevisiae"
xref: Reactome:REACT_112892 "Phosphorylation of BRCA1 at multiple sites by ATM, Oryza sativa"
xref: Reactome:REACT_112948 "Autophosphorylation of DNA-PKcs, Rattus norvegicus"
xref: Reactome:REACT_113022 "Phosphorylation of Cyclin B1 in the CRS domain, Schizosaccharomyces pombe"
xref: Reactome:REACT_113051 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta, Arabidopsis thaliana"
xref: Reactome:REACT_113121 "Phosphorylation and activation of eIF4B by activated S6K1, Schizosaccharomyces pombe"
xref: Reactome:REACT_113227 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Saccharomyces cerevisiae"
xref: Reactome:REACT_113244 "CAK-mediated phosphorylation of Cyclin E:Cdk2, Drosophila melanogaster"
xref: Reactome:REACT_113269 "Activation of S6K1, Saccharomyces cerevisiae"
xref: Reactome:REACT_113435 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta, Oryza sativa"
xref: Reactome:REACT_113527 "Autophosphorylation of DNA-PKcs, Bos taurus"
xref: Reactome:REACT_113569 "Activation of Cdc25C, Saccharomyces cerevisiae"
xref: Reactome:REACT_113811 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Bos taurus"
xref: Reactome:REACT_113820 "Phosphorylation of Cyclin B1 in the CRS domain, Saccharomyces cerevisiae"
xref: Reactome:REACT_113894 "PIP2 conversion to PIP3, Caenorhabditis elegans"
xref: Reactome:REACT_113929 "Phosphorylation of Cdc25A at Ser-123 by Chk1, Caenorhabditis elegans"
xref: Reactome:REACT_113990 "Activation of Cdc25C, Schizosaccharomyces pombe"
xref: Reactome:REACT_114160 "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes, Saccharomyces cerevisiae"
xref: Reactome:REACT_114198 "Phosphorylation of the Scc1:Cohesion Complex, Schizosaccharomyces pombe"
xref: Reactome:REACT_114207 "Phosphorylation of Cdc25A at Ser-123 by Chk1, Schizosaccharomyces pombe"
xref: Reactome:REACT_114227 "Phosphorylation of Cyclin E1:Cdk2 complexes by Myt1, Schizosaccharomyces pombe"
xref: Reactome:REACT_114233 "Autophosphorylation of DNA-PKcs, Sus scrofa"
xref: Reactome:REACT_114255 "Autophosphorylation of DNA-PKcs, Mus musculus"
xref: Reactome:REACT_114268 "Phosphorylation of Cdc25A at Ser-123 in response to DNA damage, Schizosaccharomyces pombe"
xref: Reactome:REACT_114280 "Phosphorylation of Cdc25A at Ser-123 in response to DNA damage, Saccharomyces cerevisiae"
xref: Reactome:REACT_114319 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex, Caenorhabditis elegans"
xref: Reactome:REACT_114323 "Activation of Cdc25C, Caenorhabditis elegans"
xref: Reactome:REACT_114395 "Phosphorylation of DLC1 by MAPK 8, Xenopus tropicalis"
xref: Reactome:REACT_114434 "Autophosphorylation of DNA-PKcs, Taeniopygia guttata"
xref: Reactome:REACT_114461 "Phosphorylation of AKT2 by PDK1, Schizosaccharomyces pombe"
xref: Reactome:REACT_114522 "Phosphorylation of BRCA1 at multiple sites by ATM, Arabidopsis thaliana"
xref: Reactome:REACT_114553 "Phosphorylation of Cdc25A at Ser-123 by Chk1, Saccharomyces cerevisiae"
xref: Reactome:REACT_114599 "Phosphorylation of TSC2 by PKB, Schizosaccharomyces pombe"
xref: Reactome:REACT_114624 "Phosphorylation of Cyclin E1:Cdk2 complexes by Myt1, Drosophila melanogaster"
xref: Reactome:REACT_114771 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Canis familiaris"
xref: Reactome:REACT_114906 "Phosphorylation and activation of eIF4G by activated S6K1, Arabidopsis thaliana"
xref: Reactome:REACT_114984 "Autophosphorylation of DNA-PKcs, Xenopus tropicalis"
xref: Reactome:REACT_115006 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta, Caenorhabditis elegans"
xref: Reactome:REACT_115135 "Phosphorylation and activation of eIF4G by activated S6K1, Dictyostelium discoideum"
xref: Reactome:REACT_115168 "Autophosphorylation of DNA-PKcs, Gallus gallus"
xref: Reactome:REACT_115199 "Autophosphorylation of DNA-PKcs, Canis familiaris"
xref: Reactome:REACT_115358 "Phosphorylation of Cyclin E:Cdk2 complexes by Wee-1, Drosophila melanogaster"
xref: Reactome:REACT_115384 "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes, Schizosaccharomyces pombe"
xref: Reactome:REACT_115440 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex, Danio rerio"
xref: Reactome:REACT_115472 "Phosphorylation of the SA2 Cohesin Complex, Schizosaccharomyces pombe"
xref: Reactome:REACT_115475 "CAK-mediated phosphorylation of Cyclin E:Cdk2, Schizosaccharomyces pombe"
xref: Reactome:REACT_115521 "Autophosphorylation of DNA-PKcs, Danio rerio"
xref: Reactome:REACT_115527 "Phosphorylation of Cdc25A at Ser-123 by Chk2, Schizosaccharomyces pombe"
xref: Reactome:REACT_115747 "Phosphorylation of H2AX at S139 by ATM at the site of DSB, Gallus gallus"
xref: Reactome:REACT_116149 "Phosphorylation of RAD51 by tyrosine kinase Abelson family protein members, Gallus gallus"
xref: Reactome:REACT_118137 "Phosphorylation of the Scc1:Cohesion Complex, Taeniopygia guttata"
xref: Reactome:REACT_118229 "Phosphorylation of the SA2 Cohesin Complex, Taeniopygia guttata"
xref: Reactome:REACT_118284 "Phosphorylation of the Scc1:Cohesion Complex, Saccharomyces cerevisiae"
xref: Reactome:REACT_118307 "Phosphorylation of the SA2 Cohesin Complex, Gallus gallus"
xref: Reactome:REACT_118367 "Phosphorylation of the Scc1:Cohesion Complex, Gallus gallus"
xref: Reactome:REACT_118462 "Phosphorylation of the SA2 Cohesin Complex, Saccharomyces cerevisiae"
xref: Reactome:REACT_1185 "Phosphorylation (Ser5) of RNA pol II CTD, Homo sapiens"
xref: Reactome:REACT_1279 "Cdc6 protein is phosphorylated by CDK, Homo sapiens"
xref: Reactome:REACT_128 "Phosphorylation of Cdc25C at Ser216, Homo sapiens"
xref: Reactome:REACT_132 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta, Homo sapiens"
xref: Reactome:REACT_1326 "Regulation of NUDC by phosphorylation, Homo sapiens"
xref: Reactome:REACT_13431 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Homo sapiens"
xref: Reactome:REACT_13581 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Oryctolagus cuniculus"
xref: Reactome:REACT_1362 "Phosphorylation of the Scc1:Cohesion Complex, Homo sapiens"
xref: Reactome:REACT_13817 "Autophosphorylation of PAK-2p34, Oryctolagus cuniculus"
xref: Reactome:REACT_1382 "Phosphorylation of PDE3B by AKT-1, Mus musculus"
xref: Reactome:REACT_13820 "Autophosphorylation of PAK-2p34 in the activation loop, Homo sapiens"
xref: Reactome:REACT_1420 "SOS phosphorylation and dissociation (SHC), Homo sapiens"
xref: Reactome:REACT_1481 "Phosphorylation of the SA2 Cohesin Complex, Homo sapiens"
xref: Reactome:REACT_1517 "Phosphorylation of histone H2AX at Serine-139 by ATM at the site of DSB, Homo sapiens"
xref: Reactome:REACT_15386 "Plk1-mediated phosphorylation of Nlp, Homo sapiens"
xref: Reactome:REACT_1603 "Phosphorylation and activation of CHK2 by ATM, Homo sapiens"
xref: Reactome:REACT_1657 "Phosphorylation of Cyclin E1:Cdk2 complexes by Myt1, Homo sapiens"
xref: Reactome:REACT_1680 "Phosphorylation of Cdc25A at Ser-123 in response to DNA damage, Homo sapiens"
xref: Reactome:REACT_169 "SOS phosphorylation and dissociation (IRS), Homo sapiens"
xref: Reactome:REACT_1727 "RAF1 phosphorylates MEK2, Homo sapiens"
xref: Reactome:REACT_1756 "Phosphorylation of p53 at ser-15 by ATM kinase, Homo sapiens"
xref: Reactome:REACT_1782 "Phosphorylation of MDC1/NFBD1 by ATM (within 2 c-term BRCT domains), Homo sapiens"
xref: Reactome:REACT_1808 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Homo sapiens"
xref: Reactome:REACT_1878 "Phosphorylation of PDE3B, Homo sapiens"
xref: Reactome:REACT_188 "Akt1 phosphorylates BAD protein, Homo sapiens"
xref: Reactome:REACT_1888 "Phosphorylation of DLC1 by MAPK 8, Homo sapiens"
xref: Reactome:REACT_1930 "Regulation of KIF23 (MKLP1) by phosphorylation, Homo sapiens"
xref: Reactome:REACT_19312 "Phosphorylation of PD-1, Homo sapiens"
xref: Reactome:REACT_1944 "Inactivation of Wee1 kinase, Homo sapiens"
xref: Reactome:REACT_1981 "Phosphorylation of DLC2 by MAPK-8, Homo sapiens"
xref: Reactome:REACT_2009 "Phosphorylation of NBS1 by ATM, Homo sapiens"
xref: Reactome:REACT_203 "Raf1 phosphorylates MEK1, Rattus norvegicus"
xref: Reactome:REACT_20503 "Phosphorylation of CREB by ribosomal protein S6 kinase, Homo sapiens"
xref: Reactome:REACT_20543 "Phosphorylation of COP1 at Ser-387 by ATM, Homo sapiens"
xref: Reactome:REACT_20562 "Phosphorylation by MAPK/ERK, Homo sapiens"
xref: Reactome:REACT_20578 "Raf activation, Homo sapiens"
xref: Reactome:REACT_20583 "Phosphorylation of CREB by PKA, Homo sapiens"
xref: Reactome:REACT_20631 "Activation of MAPK, Homo sapiens"
xref: Reactome:REACT_20640 "Phophorylation by PDK1, Homo sapiens"
xref: Reactome:REACT_2066 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex, Homo sapiens"
xref: Reactome:REACT_2111 "Orc1 is phosphorylated by cyclin A/CDK2, Homo sapiens"
xref: Reactome:REACT_2119 "Activation of Cdc25C, Homo sapiens"
xref: Reactome:REACT_215 "Autophosphorylation of DNA-PKcs, Homo sapiens"
xref: Reactome:REACT_22099 "Phosphorylation of L1 by ERK, Homo sapiens"
xref: Reactome:REACT_22378 "Phosphorylation of L1 by CK-II, Homo sapiens"
xref: Reactome:REACT_23976 "Raf1 phosphorylates MEK2, Rattus norvegicus"
xref: Reactome:REACT_23990 "Phosphorylation of cPLA2 by ERK-2, Homo sapiens"
xref: Reactome:REACT_244 "PIP2 conversion to PIP3, Homo sapiens"
xref: Reactome:REACT_26 "SOS phosphorylation and dissociation (IRS, Crk), Homo sapiens"
xref: Reactome:REACT_264 "Phosphorylation of Wee1 kinase by Chk1, Homo sapiens"
xref: Reactome:REACT_28054 "Phosphorylation of BRCA1 at multiple sites by ATM, Mus musculus"
xref: Reactome:REACT_28091 "Inactivation of Wee1 kinase, Canis familiaris"
xref: Reactome:REACT_28113 "RAF1 phosphorylates MEK1, Taeniopygia guttata"
xref: Reactome:REACT_28163 "Phosphorylation of MDC1/NFBD1 by ATM (within 2 c-term BRCT domains), Canis familiaris"
xref: Reactome:REACT_28264 "Phosphorylation of Wee1 kinase by Chk1, Arabidopsis thaliana"
xref: Reactome:REACT_28480 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Danio rerio"
xref: Reactome:REACT_28555 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Xenopus tropicalis"
xref: Reactome:REACT_28681 "Phosphorylation of Cyclin E:Cdk2 complexes by Wee-1, Rattus norvegicus"
xref: Reactome:REACT_28719 "Phosphorylation and activation of eIF4B by activated S6K1, Xenopus tropicalis"
xref: Reactome:REACT_28743 "RAF1 phosphorylates MEK2, Mus musculus"
xref: Reactome:REACT_28746 "Phosphorylation of MDM2 at serine-395 by ATM kinase, Danio rerio"
xref: Reactome:REACT_28824 "Down Regulation of Emi1 through Phosphorylation of Emi1, Danio rerio"
xref: Reactome:REACT_29029 "Phosphorylation of L1 by ERK, Caenorhabditis elegans"
xref: Reactome:REACT_29168 "Phosphorylation of Cyclin A:Cdk2 at Tyr 15, Canis familiaris"
xref: Reactome:REACT_29201 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Saccharomyces cerevisiae"
xref: Reactome:REACT_29213 "Activation of Cdc25C, Rattus norvegicus"
xref: Reactome:REACT_29277 "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes, Drosophila melanogaster"
xref: Reactome:REACT_29284 "Phosphorylation of beta-catenin at Ser45 by CK1 alpha, Xenopus tropicalis"
xref: Reactome:REACT_29289 "Activation of S6K1, Gallus gallus"
xref: Reactome:REACT_29300 "Phosphorylation of L1 by ERK, Drosophila melanogaster"
xref: Reactome:REACT_29334 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Rattus norvegicus"
xref: Reactome:REACT_29395 "Phosphorylation of AKT2 by PDK1, Xenopus tropicalis"
xref: Reactome:REACT_29396 "Orc1 is phosphorylated by cyclin A/CDK2, Canis familiaris"
xref: Reactome:REACT_29410 "Regulation of KIF20A (MKL2) by phosphorylation, Rattus norvegicus"
xref: Reactome:REACT_29451 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta, Bos taurus"
xref: Reactome:REACT_29588 "Phosphorylation of 4E-BP1 by activated mTORC1, Taeniopygia guttata"
xref: Reactome:REACT_29614 "Regulation of NUDC by phosphorylation, Rattus norvegicus"
xref: Reactome:REACT_29689 "Cdc6 protein is phosphorylated by CDK, Bos taurus"
xref: Reactome:REACT_29694 "Phosphorylation of PDE3B, Canis familiaris"
xref: Reactome:REACT_29759 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex, Bos taurus"
xref: Reactome:REACT_29788 "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes, Xenopus tropicalis"
xref: Reactome:REACT_29873 "Phosphorylation of APC component of the destruction complex, Taeniopygia guttata"
xref: Reactome:REACT_29914 "Down Regulation of Emi1 through Phosphorylation of Emi1, Canis familiaris"
xref: Reactome:REACT_30020 "Phosphorylation (Ser5) of RNA pol II CTD, Rattus norvegicus"
xref: Reactome:REACT_30023 "Phosphorylation (Ser5) of RNA pol II CTD, Xenopus tropicalis"
xref: Reactome:REACT_30052 "Phosphorylation of BRCA1 at multiple sites by ATM, Bos taurus"
xref: Reactome:REACT_30070 "Phosphorylation of L1 by CK-II, Mus musculus"
xref: Reactome:REACT_30084 "PIP2 conversion to PIP3, Canis familiaris"
xref: Reactome:REACT_30113 "SOS phosphorylation and dissociation (IRS, Crk), Drosophila melanogaster"
xref: Reactome:REACT_30116 "Phosphorylation and activation of eIF4B by activated S6K1, Canis familiaris"
xref: Reactome:REACT_30165 "Phosphorylation of the Emi1 DSGxxS degron by Plk1, Gallus gallus"
xref: Reactome:REACT_302 "Phosphorylation and activation of Chk1 by ATM, Homo sapiens"
xref: Reactome:REACT_30230 "Phosphorylation of the SA2 Cohesin Complex, Caenorhabditis elegans"
xref: Reactome:REACT_30345 "RAF1 phosphorylates MEK1, Gallus gallus"
xref: Reactome:REACT_30490 "Inactivation of Myt1 kinase, Danio rerio"
xref: Reactome:REACT_30496 "Phosphorylation of the Scc1:Cohesion Complex, Xenopus tropicalis"
xref: Reactome:REACT_30679 "Phosphorylation and inactivation of eEF2K by activated S6K1, Mus musculus"
xref: Reactome:REACT_30700 "Phosphorylation of BRCA1 at multiple sites by ATM, Gallus gallus"
xref: Reactome:REACT_30836 "Inactivation of Myt1 kinase, Bos taurus"
xref: Reactome:REACT_30921 "Phosphorylation and activation of Chk1 by ATM, Xenopus tropicalis"
xref: Reactome:REACT_30938 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex, Canis familiaris"
xref: Reactome:REACT_30948 "PIP2 conversion to PIP3, Gallus gallus"
xref: Reactome:REACT_30985 "Plk1-mediated phosphorylation of Nlp, Canis familiaris"
xref: Reactome:REACT_30997 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Rattus norvegicus"
xref: Reactome:REACT_31081 "Phosphorylation of TSC2 by PKB, Canis familiaris"
xref: Reactome:REACT_31149 "Phosphorylation of the Scc1:Cohesion Complex, Danio rerio"
xref: Reactome:REACT_31196 "Phosphorylation of histone H2AX at Serine-139 by ATM at the site of DSB, Canis familiaris"
xref: Reactome:REACT_31227 "Regulation of KIF20A (MKL2) by phosphorylation, Gallus gallus"
xref: Reactome:REACT_31273 "Phosphorylation of the Scc1:Cohesion Complex, Canis familiaris"
xref: Reactome:REACT_31290 "Orc1 is phosphorylated by cyclin A/CDK2, Rattus norvegicus"
xref: Reactome:REACT_31293 "Phosphorylation of Cdc25A at Ser-123 in response to DNA damage, Danio rerio"
xref: Reactome:REACT_31449 "Phosphorylation and activation of CHK2 by ATM, Danio rerio"
xref: Reactome:REACT_31466 "Activation of S6K1, Bos taurus"
xref: Reactome:REACT_31519 "Phosphorylation of the SA2 Cohesin Complex, Danio rerio"
xref: Reactome:REACT_31536 "Phosphorylation of NBS1 by ATM, Taeniopygia guttata"
xref: Reactome:REACT_31571 "Autophosphorylation of PAK-2p34 in the activation loop, Gallus gallus"
xref: Reactome:REACT_31625 "Phosphorylation of L1 by ERK, Taeniopygia guttata"
xref: Reactome:REACT_31639 "SOS phosphorylation and dissociation (SHC), Rattus norvegicus"
xref: Reactome:REACT_31868 "Phosphorylation and activation of CHK2 by ATM, Canis familiaris"
xref: Reactome:REACT_31915 "Phosphorylation of L1 by CK-II, Drosophila melanogaster"
xref: Reactome:REACT_31935 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Sus scrofa"
xref: Reactome:REACT_31984 "Phosphorylation (Ser5) of RNA pol II CTD, Arabidopsis thaliana"
xref: Reactome:REACT_32009 "Wee1- mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes, Mus musculus"
xref: Reactome:REACT_32077 "Inactivation of Myt1 kinase, Dictyostelium discoideum"
xref: Reactome:REACT_32079 "Phosphorylation of MDC1/NFBD1 by ATM (within 2 c-term BRCT domains), Danio rerio"
xref: Reactome:REACT_32145 "Phosphorylation of COP1 at Ser-387 by ATM, Canis familiaris"
xref: Reactome:REACT_32150 "Phosphorylation of NBS1 by ATM, Arabidopsis thaliana"
xref: Reactome:REACT_32271 "Phosphorylation of cPLA2 by ERK-2, Taeniopygia guttata"
xref: Reactome:REACT_32358 "Phosphorylation of MDM2 at serine-395 by ATM kinase, Canis familiaris"
xref: Reactome:REACT_32374 "Mcm2-7 is phosphorylated by DDK, Canis familiaris"
xref: Reactome:REACT_32438 "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2, Sus scrofa"
xref: Reactome:REACT_32492 "Phosphorylation of BRCA1 at multiple sites by ATM, Rattus norvegicus"
xref: Reactome:REACT_32565 "Phosphorylation of NBS1 by ATM, Gallus gallus"
xref: Reactome:REACT_32598 "Phosphorylation and activation of eIF4B by activated S6K1, Taeniopygia guttata"
xref: Reactome:REACT_32620 "Phosphorylation of the Emi1 DSGxxS degron by Plk1, Bos taurus"
xref: Reactome:REACT_32845 "Phosphorylation of Cyclin D:Cdk4/6 complexes, Rattus norvegicus"
xref: Reactome:REACT_32906 "Phosphorylation and inactivation of eEF2K by activated S6K1, Sus scrofa"
xref: Reactome:REACT_32956 "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3, Mus musculus"
xref: Reactome:REACT_33003 "Phosphorylation of the SA2 Cohesin Complex, Dictyostelium discoideum"
xref: Reactome:REACT_33009 "Phosphorylation of L1 by ERK, Danio rerio"
xref: Reactome:REACT_33080 "Phosphorylation of histone H2AX at Serine-139 by ATM at the site of DSB, Taeniopygia guttata"
xref: Reactome:REACT_33369 "Phosphorylation of NBS1 by ATM, Rattus norvegicus"
xref: Reactome:REACT_33385 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Canis familiaris"
xref: Reactome:REACT_33519 "Phosphorylation of the Emi1 DSGxxS degron by Plk1, Mus musculus"
xref: Reactome:REACT_33532 "Phosphorylation of complexed TSC2 by PKB, Bos taurus"
xref: Reactome:REACT_33692 "Phosphorylation of BRCA1 at multiple sites by ATM, Taeniopygia guttata"
xref: Reactome:REACT_33840 "Regulation of KIF23 (MKLP1) by phosphorylation, Schizosaccharomyces pombe"
xref: Reactome:REACT_33928 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta, Sus scrofa"
xref: Reactome:REACT_33979 "Phosphorylation of the Emi1 DSGxxS degron by Plk1, Rattus norvegicus"
xref: Reactome:REACT_34080 "Phosphorylation of PD-1, Mus musculus"
xref: Reactome:REACT_34111 "Phosphorylation of Cdc25A at Ser-123 by Chk1, Canis familiaris"
xref: Reactome:REACT_34145 "Phosphorylation of cPLA2 by ERK-2, Xenopus tropicalis"
xref: Reactome:REACT_34222 "Phosphorylation of L1 by ERK, Rattus norvegicus"
xref: Reactome:REACT_34285 "Activation of Cdc25C, Bos taurus"
xref: Reactome:REACT_34310 "Phosphorylation and activation of Chk1 by ATM, Bos taurus"
xref: Reactome:REACT_34403 "Phosphorylation (Ser5) of RNA pol II CTD, Danio rerio"
xref: Reactome:REACT_34514 "Phosphorylation and inactivation of eEF2K by activated S6K1, Danio rerio"
xref: Reactome:REACT_34516 "Cdc6 protein is phosphorylated by CDK, Canis familiaris"
xref: Reactome:REACT_34607 "Phosphorylation of 4E-BP1 by activated mTORC1, Bos taurus"
xref: Reactome:REACT_34741 "Phosphorylation of MDC1/NFBD1 by ATM (within 2 c-term BRCT domains), Rattus norvegicus"
xref: Reactome:REACT_34788 "Phosphorylation and inactivation of eEF2K by activated S6K1, Xenopus tropicalis"
xref: Reactome:REACT_34804 "Phosphoryation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3, Gallus gallus"
xref: Reactome:REACT_384 "Phosphorylation of Cyclin E2:Cdk2 complexes by Myt1, Homo sapiens"
xref: Reactome:REACT_414 "Inactivation of Myt1 kinase, Homo sapiens"
xref: Reactome:REACT_41715 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex, Mus musculus"
xref: Reactome:REACT_43 "Phosphorylation of Cdc25A at Ser-123 by Chk2, Homo sapiens"
xref: Reactome:REACT_496 "Down Regulation of Emi1 through Phosphorylation of Emi1, Homo sapiens"
xref: Reactome:REACT_54449 "Phosphorylation and activation of eIF4G by activated S6K1, Mus musculus"
xref: Reactome:REACT_545 "RAF1 phosphorylates MEK1, Homo sapiens"
xref: Reactome:REACT_559 "Phosphorylation and activation of Chk1 by ATM kinase, Mus musculus"
xref: Reactome:REACT_58131 "PIP2 conversion to PIP3, Mus musculus"
xref: Reactome:REACT_6139 "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes, Homo sapiens"
xref: Reactome:REACT_6170 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by the P-TEFb(Cyclin T1:Cdk9) complex, Homo sapiens"
xref: Reactome:REACT_6178 "Wee1- mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes, Homo sapiens"
xref: Reactome:REACT_6234 "Phosphorylation (Ser5) of RNA pol II CTD, Homo sapiens"
xref: Reactome:REACT_6297 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex, Homo sapiens"
xref: Reactome:REACT_6311 "Phosphorylation of NEFL by the P-TEFb(Cyclin T1:Cdk9) complex, Homo sapiens"
xref: Reactome:REACT_6314 "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes, Homo sapiens"
xref: Reactome:REACT_6316 "Phosphorylation of DSIF by the P-TEFb(Cyclin T1:Cdk9) complex, Human immunodeficiency virus 1"
xref: Reactome:REACT_6327 "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes, Homo sapiens"
xref: Reactome:REACT_6342 "Myt-1 mediated phosphorylation of Cyclin A:Cdc2, Homo sapiens"
xref: Reactome:REACT_6353 "Phosphorylation of Cyclin B1 in the CRS domain, Homo sapiens"
xref: Reactome:REACT_6725 "Phosphorylation of TSC2 by PKB, Homo sapiens"
xref: Reactome:REACT_6778 "Phosphorylation and activation of eIF4B by activated S6K1, Homo sapiens"
xref: Reactome:REACT_6859 "Free APC/C phosphorylated by Plk1, Homo sapiens"
xref: Reactome:REACT_6861 "Phosphorylation of the Emi1 DSGxxS degron by Plk1, Homo sapiens"
xref: Reactome:REACT_6870 "Phosphorylation and activation of eIF4G by activated S6K1, Homo sapiens"
xref: Reactome:REACT_6873 "Phosphorylation of 4E-BP1 by activated mTORC1, Homo sapiens"
xref: Reactome:REACT_6883 "Phosphorylation and inactivation of eEF2K by activated S6K1, Homo sapiens"
xref: Reactome:REACT_6912 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Homo sapiens"
xref: Reactome:REACT_6948 "Activation of S6K1, Homo sapiens"
xref: Reactome:REACT_6952 "Phosphorylation of complexed TSC2 by PKB, Homo sapiens"
xref: Reactome:REACT_76979 "Phosphorylation of Cyclin D:Cdk4/6 complexes, Danio rerio"
xref: Reactome:REACT_77040 "Phosphorylation of COP1 at Ser-387 by ATM, Oryza sativa"
xref: Reactome:REACT_77074 "Phosphorylation of MDM2 at serine-395 by ATM kinase, Mus musculus"
xref: Reactome:REACT_77179 "Phosphorylation of Cdc25A at Ser-123 by Chk2, Bos taurus"
xref: Reactome:REACT_77231 "Phosphorylation of DLC2 by MAPK-8, Gallus gallus"
xref: Reactome:REACT_77234 "Plk1-mediated phosphorylation of Nlp, Gallus gallus"
xref: Reactome:REACT_773 "Phosphorylation of Cyclin E:Cdk2 complexes by Wee-1, Homo sapiens"
xref: Reactome:REACT_77326 "RAF1 phosphorylates MEK2, Taeniopygia guttata"
xref: Reactome:REACT_77362 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Rattus norvegicus"
xref: Reactome:REACT_77365 "Phosphorylation of the Emi1 DSGxxS degron by Plk1, Xenopus tropicalis"
xref: Reactome:REACT_77397 "Phosphorylation of Cdc25A at Ser-123 in response to DNA damage, Mus musculus"
xref: Reactome:REACT_77407 "Regulation of NUDC by phosphorylation, Bos taurus"
xref: Reactome:REACT_77443 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Danio rerio"
xref: Reactome:REACT_77450 "Phosphorylation of L1 by CK-II, Sus scrofa"
xref: Reactome:REACT_77535 "Phosphorylation of Cyclin D:Cdk4/6 complexes, Mus musculus"
xref: Reactome:REACT_77550 "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes, Drosophila melanogaster"
xref: Reactome:REACT_77566 "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes, Gallus gallus"
xref: Reactome:REACT_77606 "Phosphoryation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3, Canis familiaris"
xref: Reactome:REACT_77615 "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3, Gallus gallus"
xref: Reactome:REACT_77654 "CAK-mediated phosphorylation of Cyclin A:Cdk2, Drosophila melanogaster"
xref: Reactome:REACT_77660 "Regulation of KIF23 (MKLP1) by phosphorylation, Caenorhabditis elegans"
xref: Reactome:REACT_77733 "Phosphorylation of PDE3B, Danio rerio"
xref: Reactome:REACT_77834 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Rattus norvegicus"
xref: Reactome:REACT_77857 "Phosphorylation (Ser5) of RNA pol II CTD, Drosophila melanogaster"
xref: Reactome:REACT_77897 "Phosphorylation of Wee1 kinase by Chk1, Taeniopygia guttata"
xref: Reactome:REACT_77911 "Mcm2-7 is phosphorylated by DDK, Taeniopygia guttata"
xref: Reactome:REACT_77928 "Autophosphorylation of PAK-2p34 in the activation loop, Sus scrofa"
xref: Reactome:REACT_77949 "Phosphorylation of Wee1 kinase by Chk1, Drosophila melanogaster"
xref: Reactome:REACT_77977 "Phosphorylation of Cyclin B1 in the CRS domain, Bos taurus"
xref: Reactome:REACT_78014 "Plk1-mediated phosphorylation of Nlp, Taeniopygia guttata"
xref: Reactome:REACT_78035 "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3, Taeniopygia guttata"
xref: Reactome:REACT_78087 "Phosphorylation of TSC2 by PKB, Xenopus tropicalis"
xref: Reactome:REACT_78121 "Phosphorylation of Cdc25A at Ser-123 by Chk2, Gallus gallus"
xref: Reactome:REACT_78226 "Regulation of NUDC by phosphorylation, Xenopus tropicalis"
xref: Reactome:REACT_78281 "Phosphoryation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3, Rattus norvegicus"
xref: Reactome:REACT_78427 "Myt-1 mediated phosphorylation of Cyclin A:Cdc2, Danio rerio"
xref: Reactome:REACT_78450 "Phosphorylation and activation of eIF4B by activated S6K1, Drosophila melanogaster"
xref: Reactome:REACT_78451 "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes, Taeniopygia guttata"
xref: Reactome:REACT_78503 "Phosphorylation of histone H2AX at Serine-139 by ATM at the site of DSB, Bos taurus"
xref: Reactome:REACT_78533 "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes, Danio rerio"
xref: Reactome:REACT_78539 "Down Regulation of Emi1 through Phosphorylation of Emi1, Xenopus tropicalis"
xref: Reactome:REACT_78556 "Free APC/C phosphorylated by Plk1, Drosophila melanogaster"
xref: Reactome:REACT_78625 "Phosphorylation and inactivation of eEF2K by activated S6K1, Caenorhabditis elegans"
xref: Reactome:REACT_78651 "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes, Rattus norvegicus"
xref: Reactome:REACT_78696 "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3, Xenopus tropicalis"
xref: Reactome:REACT_78748 "Cdc6 protein is phosphorylated by CDK, Drosophila melanogaster"
xref: Reactome:REACT_78901 "Phosphorylation (Ser5) of RNA pol II CTD, Mus musculus"
xref: Reactome:REACT_79012 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Schizosaccharomyces pombe"
xref: Reactome:REACT_79039 "Autophosphorylation of PAK-2p34 in the activation loop, Caenorhabditis elegans"
xref: Reactome:REACT_79087 "Phosphorylation of Wee1 kinase by Chk1, Oryza sativa"
xref: Reactome:REACT_79125 "SOS phosphorylation and dissociation (IRS), Bos taurus"
xref: Reactome:REACT_79182 "Phosphorylation of Cyclin B1 in the CRS domain, Canis familiaris"
xref: Reactome:REACT_79208 "Mcm2-7 is phosphorylated by DDK, Bos taurus"
xref: Reactome:REACT_79220 "Phosphorylation of 4E-BP1 by activated mTORC1, Canis familiaris"
xref: Reactome:REACT_79255 "Phosphorylation of p53 at ser-15 by ATM kinase, Danio rerio"
xref: Reactome:REACT_79372 "Cdc6 protein is phosphorylated by CDK, Danio rerio"
xref: Reactome:REACT_79573 "Phosphorylation of p53 at ser-15 by ATM kinase, Mus musculus"
xref: Reactome:REACT_79686 "Phosphorylation of the Scc1:Cohesion Complex, Drosophila melanogaster"
xref: Reactome:REACT_79694 "Autophosphorylation of PAK-2p34 in the activation loop, Xenopus tropicalis"
xref: Reactome:REACT_79700 "Activation of S6K1, Taeniopygia guttata"
xref: Reactome:REACT_79709 "Orc1 is phosphorylated by cyclin A/CDK2, Mus musculus"
xref: Reactome:REACT_79720 "Phosphorylation of Cyclin E2:Cdk2 complexes by Myt1, Danio rerio"
xref: Reactome:REACT_80110 "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2, Drosophila melanogaster"
xref: Reactome:REACT_80144 "Phosphorylation of complexed TSC2 by PKB, Sus scrofa"
xref: Reactome:REACT_80185 "Phosphorylation of Cyclin E1:Cdk2 complexes by Myt1, Mus musculus"
xref: Reactome:REACT_80213 "Activation of S6K1, Canis familiaris"
xref: Reactome:REACT_80218 "Phosphorylation of the Scc1:Cohesion Complex, Dictyostelium discoideum"
xref: Reactome:REACT_80239 "Regulation of KIF20A (MKL2) by phosphorylation, Dictyostelium discoideum"
xref: Reactome:REACT_80255 "Mcm2-7 is phosphorylated by DDK, Mus musculus"
xref: Reactome:REACT_80591 "Regulation of KIF20A (MKL2) by phosphorylation, Drosophila melanogaster"
xref: Reactome:REACT_80606 "Phosphorylation of NBS1 by ATM, Oryza sativa"
xref: Reactome:REACT_80617 "Inactivation of Wee1 kinase, Xenopus tropicalis"
xref: Reactome:REACT_80632 "Phosphorylation of L1 by ERK, Schizosaccharomyces pombe"
xref: Reactome:REACT_80665 "Down Regulation of Emi1 through Phosphorylation of Emi1, Taeniopygia guttata"
xref: Reactome:REACT_80684 "Phosphorylation of COP1 at Ser-387 by ATM, Arabidopsis thaliana"
xref: Reactome:REACT_80689 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Oryza sativa"
xref: Reactome:REACT_80699 "PIP2 conversion to PIP3, Danio rerio"
xref: Reactome:REACT_80700 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Sus scrofa"
xref: Reactome:REACT_80714 "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes, Rattus norvegicus"
xref: Reactome:REACT_80804 "Phosphorylation of PDE3B, Bos taurus"
xref: Reactome:REACT_80853 "Phosphorylation (Ser5) of RNA pol II CTD, Dictyostelium discoideum"
xref: Reactome:REACT_80860 "Phosphorylation of MDM2 at serine-395 by ATM kinase, Rattus norvegicus"
xref: Reactome:REACT_80909 "Phosphorylation of Cdc25A at Ser-123 by Chk1, Drosophila melanogaster"
xref: Reactome:REACT_81027 "PIP2 conversion to PIP3, Sus scrofa"
xref: Reactome:REACT_81148 "Phosphorylation and activation of CHK2 by ATM, Taeniopygia guttata"
xref: Reactome:REACT_81218 "Phosphorylation and activation of CHK2 by ATM, Rattus norvegicus"
xref: Reactome:REACT_81439 "Phosphorylation of APC component of the destruction complex, Xenopus tropicalis"
xref: Reactome:REACT_81458 "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3, Bos taurus"
xref: Reactome:REACT_81490 "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3, Xenopus tropicalis"
xref: Reactome:REACT_81590 "Wee1- mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes, Bos taurus"
xref: Reactome:REACT_81616 "Phosphorylation of Cyclin E2:Cdk2 complexes by Myt1, Canis familiaris"
xref: Reactome:REACT_81647 "Phosphorylation of Cyclin E1:Cdk2 complexes by Myt1, Rattus norvegicus"
xref: Reactome:REACT_81652 "Phosphorylation of Cdc25A at Ser-123 by Chk1, Rattus norvegicus"
xref: Reactome:REACT_81693 "Phosphorylation of beta-catenin at Ser45 by CK1 alpha, Drosophila melanogaster"
xref: Reactome:REACT_81715 "Orc1 is phosphorylated by cyclin A/CDK2, Drosophila melanogaster"
xref: Reactome:REACT_81727 "Phosphorylation of Cyclin A:Cdk2 at Tyr 15, Danio rerio"
xref: Reactome:REACT_81864 "Phosphorylation of Cx43 by c-src, Bos taurus"
xref: Reactome:REACT_81941 "Phosphorylation of Cdc25A at Ser-123 by Chk1, Bos taurus"
xref: Reactome:REACT_82037 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Mus musculus"
xref: Reactome:REACT_82115 "Phosphorylation and activation of Chk1 by ATM, Saccharomyces cerevisiae"
xref: Reactome:REACT_82125 "Phosphorylation of complexed TSC2 by PKB, Danio rerio"
xref: Reactome:REACT_82128 "PIP2 conversion to PIP3, Taeniopygia guttata"
xref: Reactome:REACT_82261 "Phosphorylation of DLC2 by MAPK-8, Xenopus tropicalis"
xref: Reactome:REACT_82270 "Autophosphorylation of PAK-2p34 in the activation loop, Rattus norvegicus"
xref: Reactome:REACT_82303 "Phosphorylation of Cyclin D:Cdk4/6 complexes, Xenopus tropicalis"
xref: Reactome:REACT_82310 "Phosphorylation and activation of Chk1 by ATM, Gallus gallus"
xref: Reactome:REACT_82361 "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes, Canis familiaris"
xref: Reactome:REACT_82456 "Phosphorylation of Cdc25A at Ser-123 in response to DNA damage, Bos taurus"
xref: Reactome:REACT_82473 "Phosphorylation of the SA2 Cohesin Complex, Canis familiaris"
xref: Reactome:REACT_82616 "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3, Mus musculus"
xref: Reactome:REACT_82678 "Phosphorylation of complexed TSC2 by PKB, Rattus norvegicus"
xref: Reactome:REACT_82728 "Plk1-mediated phosphorylation of Nlp, Mus musculus"
xref: Reactome:REACT_82751 "Down Regulation of Emi1 through Phosphorylation of Emi1, Rattus norvegicus"
xref: Reactome:REACT_82824 "Inactivation of Wee1 kinase, Rattus norvegicus"
xref: Reactome:REACT_82901 "Phosphorylation of DLC2 by MAPK-8, Canis familiaris"
xref: Reactome:REACT_82927 "PIP2 conversion to PIP3, Rattus norvegicus"
xref: Reactome:REACT_83006 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Caenorhabditis elegans"
xref: Reactome:REACT_83089 "Inactivation of Myt1 kinase, Saccharomyces cerevisiae"
xref: Reactome:REACT_83110 "Phosphorylation (Ser5) of RNA pol II CTD, Schizosaccharomyces pombe"
xref: Reactome:REACT_83178 "Phosphorylation and activation of Chk1 by ATM, Oryza sativa"
xref: Reactome:REACT_83187 "Phosphorylation of the SA2 Cohesin Complex, Mus musculus"
xref: Reactome:REACT_83239 "Phosphorylation and activation of eIF4G by activated S6K1, Gallus gallus"
xref: Reactome:REACT_83279 "Phosphorylation of NBS1 by ATM, Canis familiaris"
xref: Reactome:REACT_83297 "CAK-mediated phosphorylation of Cyclin A:Cdk2, Danio rerio"
xref: Reactome:REACT_83436 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Arabidopsis thaliana"
xref: Reactome:REACT_83476 "Phosphorylation and activation of CHK2 by ATM, Mus musculus"
xref: Reactome:REACT_83529 "Wee1- mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes, Drosophila melanogaster"
xref: Reactome:REACT_83533 "Phosphorylation and activation of Chk1 by ATM, Rattus norvegicus"
xref: Reactome:REACT_83579 "Phosphorylation of Wee1 kinase by Chk1, Gallus gallus"
xref: Reactome:REACT_83582 "Plk1-mediated phosphorylation of Nlp, Danio rerio"
xref: Reactome:REACT_83671 "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes, Taeniopygia guttata"
xref: Reactome:REACT_83696 "Free APC/C phosphorylated by Plk1, Bos taurus"
xref: Reactome:REACT_83709 "Phosphorylation of Cdc25A at Ser-123 by Chk1, Mus musculus"
xref: Reactome:REACT_83727 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Gallus gallus"
xref: Reactome:REACT_83899 "Phosphorylation of MDC1/NFBD1 by ATM (within 2 c-term BRCT domains), Sus scrofa"
xref: Reactome:REACT_83979 "Phosphorylation of COP1 at Ser-387 by ATM, Mus musculus"
xref: Reactome:REACT_84080 "Phosphorylation of the SA2 Cohesin Complex, Xenopus tropicalis"
xref: Reactome:REACT_84082 "Phosphorylation of Wee1 kinase by Chk1, Rattus norvegicus"
xref: Reactome:REACT_84208 "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes, Mus musculus"
xref: Reactome:REACT_84273 "Phosphorylation of L1 by ERK, Sus scrofa"
xref: Reactome:REACT_84348 "Phosphorylation of COP1 at Ser-387 by ATM, Taeniopygia guttata"
xref: Reactome:REACT_84405 "Phosphorylation of p53 at ser-15 by ATM kinase, Rattus norvegicus"
xref: Reactome:REACT_845 "Phosphorylation of Cdc25A at Ser-123 by Chk1, Homo sapiens"
xref: Reactome:REACT_84560 "Cdc6 protein is phosphorylated by CDK, Saccharomyces cerevisiae"
xref: Reactome:REACT_84656 "Phosphoryation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3, Bos taurus"
xref: Reactome:REACT_84932 "Phosphorylation of Wee1 kinase by Chk1, Sus scrofa"
xref: Reactome:REACT_85009 "Phosphorylation of beta-catenin at Ser45 by CK1 alpha, Taeniopygia guttata"
xref: Reactome:REACT_85017 "Activation of S6K1, Dictyostelium discoideum"
xref: Reactome:REACT_85044 "Phosphorylation of Cyclin E1:Cdk2 complexes by Myt1, Canis familiaris"
xref: Reactome:REACT_85066 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Taeniopygia guttata"
xref: Reactome:REACT_85256 "Phosphorylation of Cdc25C at Ser216, Mus musculus"
xref: Reactome:REACT_85328 "Regulation of KIF20A (MKL2) by phosphorylation, Mus musculus"
xref: Reactome:REACT_85379 "Phosphorylation of Cx43 by c-src, Sus scrofa"
xref: Reactome:REACT_85449 "Phosphorylation and activation of eIF4G by activated S6K1, Bos taurus"
xref: Reactome:REACT_85586 "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes, Gallus gallus"
xref: Reactome:REACT_85699 "Phosphorylation of Cyclin B1 in the CRS domain, Rattus norvegicus"
xref: Reactome:REACT_85720 "Phosphorylation of L1 by ERK, Canis familiaris"
xref: Reactome:REACT_85745 "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes, Xenopus tropicalis"
xref: Reactome:REACT_85751 "Phosphorylation of BRCA1 at multiple sites by ATM, Canis familiaris"
xref: Reactome:REACT_85812 "Phosphorylation and activation of Chk1 by ATM, Drosophila melanogaster"
xref: Reactome:REACT_85836 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Gallus gallus"
xref: Reactome:REACT_85871 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Mus musculus"
xref: Reactome:REACT_86014 "Phosphorylation of the SA2 Cohesin Complex, Bos taurus"
xref: Reactome:REACT_86033 "Phosphorylation and activation of CHK2 by ATM, Schizosaccharomyces pombe"
xref: Reactome:REACT_86061 "Phosphorylation of Cyclin E1:Cdk2 complexes by Myt1, Bos taurus"
xref: Reactome:REACT_86092 "Phosphorylation of COP1 at Ser-387 by ATM, Bos taurus"
xref: Reactome:REACT_86211 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Saccharomyces cerevisiae"
xref: Reactome:REACT_86252 "Phosphorylation of Cyclin A:Cdk2 at Tyr 15, Drosophila melanogaster"
xref: Reactome:REACT_86261 "Regulation of NUDC by phosphorylation, Dictyostelium discoideum"
xref: Reactome:REACT_86277 "Phosphorylation of TSC2 by PKB, Bos taurus"
xref: Reactome:REACT_86365 "Phosphorylation and activation of eIF4G by activated S6K1, Rattus norvegicus"
xref: Reactome:REACT_86372 "Akt1 phosphorylates BAD protein, Mus musculus"
xref: Reactome:REACT_86415 "Phosphorylation of Cx43 by c-src, Xenopus tropicalis"
xref: Reactome:REACT_86422 "Phosphorylation of PD-1, Rattus norvegicus"
xref: Reactome:REACT_86533 "Cdc6 protein is phosphorylated by CDK, Sus scrofa"
xref: Reactome:REACT_86736 "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2, Rattus norvegicus"
xref: Reactome:REACT_86800 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta, Danio rerio"
xref: Reactome:REACT_86867 "Phosphorylation of p53 at ser-15 by ATM kinase, Bos taurus"
xref: Reactome:REACT_86952 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Sus scrofa"
xref: Reactome:REACT_86967 "Phosphorylation (Ser5) of RNA pol II CTD, Gallus gallus"
xref: Reactome:REACT_87010 "Regulation of NUDC by phosphorylation, Danio rerio"
xref: Reactome:REACT_87121 "Phosphorylation of cPLA2 by ERK-2, Bos taurus"
xref: Reactome:REACT_87149 "Phosphorylation of L1 by CK-II, Danio rerio"
xref: Reactome:REACT_87212 "Phosphorylation of Cx43 by c-src, Mus musculus"
xref: Reactome:REACT_87222 "Cdc6 protein is phosphorylated by CDK, Schizosaccharomyces pombe"
xref: Reactome:REACT_87298 "Phosphorylation of Cyclin A:Cdk2 at Tyr 15, Sus scrofa"
xref: Reactome:REACT_87329 "Regulation of KIF23 (MKLP1) by phosphorylation, Mus musculus"
xref: Reactome:REACT_87391 "Phosphorylation of Cx43 by c-src, Rattus norvegicus"
xref: Reactome:REACT_87424 "SOS phosphorylation and dissociation (SHC), Danio rerio"
xref: Reactome:REACT_87437 "Phosphorylation of AKT2 by PDK1, Caenorhabditis elegans"
xref: Reactome:REACT_87485 "Activation of S6K1, Xenopus tropicalis"
xref: Reactome:REACT_87497 "Akt1 phosphorylates BAD protein, Bos taurus"
xref: Reactome:REACT_87503 "Phosphorylation of Cyclin E2:Cdk2 complexes by Myt1, Xenopus tropicalis"
xref: Reactome:REACT_87523 "Phosphorylation of Cyclin B1 in the CRS domain, Mus musculus"
xref: Reactome:REACT_87534 "Phosphorylation of MDM2 at serine-395 by ATM kinase, Gallus gallus"
xref: Reactome:REACT_87593 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Gallus gallus"
xref: Reactome:REACT_87650 "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2, Xenopus tropicalis"
xref: Reactome:REACT_87679 "Phosphorylation of PDE3B, Xenopus tropicalis"
xref: Reactome:REACT_87753 "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes, Bos taurus"
xref: Reactome:REACT_87880 "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes, Danio rerio"
xref: Reactome:REACT_87967 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex, Xenopus tropicalis"
xref: Reactome:REACT_88025 "Activation of S6K1, Mus musculus"
xref: Reactome:REACT_88055 "Phosphorylation of NBS1 by ATM, Sus scrofa"
xref: Reactome:REACT_88091 "Phosphorylation of Cdc25A at Ser-123 by Chk1, Xenopus tropicalis"
xref: Reactome:REACT_88220 "Regulation of KIF23 (MKLP1) by phosphorylation, Rattus norvegicus"
xref: Reactome:REACT_88298 "Phosphorylation of Cdc25A at Ser-123 by Chk1, Taeniopygia guttata"
xref: Reactome:REACT_88326 "CAK-mediated phosphorylation of Cyclin A:Cdk2, Canis familiaris"
xref: Reactome:REACT_88374 "CAK-mediated phosphorylation of Cyclin A:Cdk2, Xenopus tropicalis"
xref: Reactome:REACT_88421 "Phosphorylation and inactivation of eEF2K by activated S6K1, Rattus norvegicus"
xref: Reactome:REACT_88430 "Orc1 is phosphorylated by cyclin A/CDK2, Bos taurus"
xref: Reactome:REACT_88440 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Caenorhabditis elegans"
xref: Reactome:REACT_88458 "Phosphorylation of cPLA2 by ERK-2, Danio rerio"
xref: Reactome:REACT_88486 "Inactivation of Wee1 kinase, Taeniopygia guttata"
xref: Reactome:REACT_88516 "Cdc6 protein is phosphorylated by CDK, Rattus norvegicus"
xref: Reactome:REACT_88548 "Phosphorylation of the Emi1 DSGxxS degron by Plk1, Taeniopygia guttata"
xref: Reactome:REACT_88564 "Plk1-mediated phosphorylation of Nlp, Xenopus tropicalis"
xref: Reactome:REACT_88590 "Phosphorylation of Cdc25A at Ser-123 by Chk2, Rattus norvegicus"
xref: Reactome:REACT_88665 "Phosphorylation of Cdc25A at Ser-123 by Chk2, Danio rerio"
xref: Reactome:REACT_88668 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Drosophila melanogaster"
xref: Reactome:REACT_88766 "Phosphorylation (Ser5) of RNA pol II CTD, Oryza sativa"
xref: Reactome:REACT_88871 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex, Rattus norvegicus"
xref: Reactome:REACT_88928 "Autophosphorylation of PAK-2p34 in the activation loop, Drosophila melanogaster"
xref: Reactome:REACT_88987 "Free APC/C phosphorylated by Plk1, Canis familiaris"
xref: Reactome:REACT_89001 "Phosphorylation of Cdc25A at Ser-123 by Chk1, Gallus gallus"
xref: Reactome:REACT_89026 "Phosphorylation of PD-1, Gallus gallus"
xref: Reactome:REACT_89122 "Activation of Cdc25C, Canis familiaris"
xref: Reactome:REACT_89366 "Phosphorylation of APC component of the destruction complex, Canis familiaris"
xref: Reactome:REACT_89427 "Phosphorylation of AKT2 by PDK1, Bos taurus"
xref: Reactome:REACT_89464 "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3, Taeniopygia guttata"
xref: Reactome:REACT_89547 "Phosphorylation of NBS1 by ATM, Xenopus tropicalis"
xref: Reactome:REACT_89579 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Xenopus tropicalis"
xref: Reactome:REACT_89769 "Phosphorylation of MDM2 at serine-395 by ATM kinase, Taeniopygia guttata"
xref: Reactome:REACT_89794 "Phosphorylation of beta-catenin at Ser45 by CK1 alpha, Mus musculus"
xref: Reactome:REACT_89879 "Phosphoryation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3, Mus musculus"
xref: Reactome:REACT_89988 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Schizosaccharomyces pombe"
xref: Reactome:REACT_9007 "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2, Homo sapiens"
xref: Reactome:REACT_90132 "Phosphorylation of AKT2 by PDK1, Sus scrofa"
xref: Reactome:REACT_90167 "Phosphorylation of Wee1 kinase by Chk1, Bos taurus"
xref: Reactome:REACT_90220 "Wee1- mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes, Rattus norvegicus"
xref: Reactome:REACT_90227 "Phosphorylation of AKT2 by PDK1, Mus musculus"
xref: Reactome:REACT_90290 "Phosphorylation of Cdc25A at Ser-123 in response to DNA damage, Taeniopygia guttata"
xref: Reactome:REACT_90364 "Regulation of NUDC by phosphorylation, Canis familiaris"
xref: Reactome:REACT_90426 "Phosphorylation of Wee1 kinase by Chk1, Mus musculus"
xref: Reactome:REACT_90449 "Phosphorylation of Cyclin E:Cdk2 complexes by Wee-1, Canis familiaris"
xref: Reactome:REACT_90562 "Regulation of NUDC by phosphorylation, Drosophila melanogaster"
xref: Reactome:REACT_9057 "Phosphorylation of Cyclin A:Cdk2 at Tyr 15, Homo sapiens"
xref: Reactome:REACT_9067 "CAK-mediated phosphorylation of Cyclin E:Cdk2, Homo sapiens"
xref: Reactome:REACT_90675 "Phosphorylation (Ser5) of RNA pol II CTD, Caenorhabditis elegans"
xref: Reactome:REACT_907 "Mcm2-7 is phosphorylated by DDK, Homo sapiens"
xref: Reactome:REACT_9070 "CAK-mediated phosphorylation of Cyclin A:Cdk2, Homo sapiens"
xref: Reactome:REACT_908 "Phosphorylation of AKT2 by PDK1, Homo sapiens"
xref: Reactome:REACT_90917 "Phosphorylation of Wee1 kinase by Chk1, Canis familiaris"
xref: Reactome:REACT_91050 "SOS phosphorylation and dissociation (IRS, Crk), Mus musculus"
xref: Reactome:REACT_91062 "Phosphorylation of Cyclin E2:Cdk2 complexes by Myt1, Bos taurus"
xref: Reactome:REACT_91085 "Inactivation of Wee1 kinase, Danio rerio"
xref: Reactome:REACT_91156 "Phosphorylation and activation of CHK2 by ATM, Gallus gallus"
xref: Reactome:REACT_91157 "Phosphorylation (Ser5) of RNA pol II CTD, Saccharomyces cerevisiae"
xref: Reactome:REACT_91196 "Phosphorylation of 4E-BP1 by activated mTORC1, Mus musculus"
xref: Reactome:REACT_91197 "Phosphorylation and activation of eIF4B by activated S6K1, Mus musculus"
xref: Reactome:REACT_91240 "Phosphorylation of Cdc25A at Ser-123 by Chk2, Xenopus tropicalis"
xref: Reactome:REACT_91263 "Down Regulation of Emi1 through Phosphorylation of Emi1, Gallus gallus"
xref: Reactome:REACT_91382 "SOS phosphorylation and dissociation (IRS), Danio rerio"
xref: Reactome:REACT_91470 "Regulation of KIF20A (MKL2) by phosphorylation, Canis familiaris"
xref: Reactome:REACT_91501 "PIP2 conversion to PIP3, Bos taurus"
xref: Reactome:REACT_91541 "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3, Rattus norvegicus"
xref: Reactome:REACT_91574 "Phosphorylation of DLC2 by MAPK-8, Rattus norvegicus"
xref: Reactome:REACT_91643 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta, Drosophila melanogaster"
xref: Reactome:REACT_91684 "Phosphorylation of the SA2 Cohesin Complex, Drosophila melanogaster"
xref: Reactome:REACT_91760 "Regulation of KIF23 (MKLP1) by phosphorylation, Danio rerio"
xref: Reactome:REACT_91937 "Phosphorylation of APC component of the destruction complex, Bos taurus"
xref: Reactome:REACT_92033 "Inactivation of Myt1 kinase, Caenorhabditis elegans"
xref: Reactome:REACT_92108 "Myt-1 mediated phosphorylation of Cyclin A:Cdc2, Rattus norvegicus"
xref: Reactome:REACT_92126 "Activation of S6K1, Oryza sativa"
xref: Reactome:REACT_92148 "Autophosphorylation of PAK-2p34 in the activation loop, Danio rerio"
xref: Reactome:REACT_92219 "Phosphorylation of PDE3B, Caenorhabditis elegans"
xref: Reactome:REACT_92247 "Phosphorylation of the Emi1 DSGxxS degron by Plk1, Canis familiaris"
xref: Reactome:REACT_92407 "Regulation of KIF23 (MKLP1) by phosphorylation, Canis familiaris"
xref: Reactome:REACT_92735 "Autophosphorylation of PAK-2p34 in the activation loop, Taeniopygia guttata"
xref: Reactome:REACT_92736 "Phosphorylation of L1 by ERK, Gallus gallus"
xref: Reactome:REACT_92804 "Phosphorylation of Wee1 kinase by Chk1, Danio rerio"
xref: Reactome:REACT_92852 "SOS phosphorylation and dissociation (SHC), Canis familiaris"
xref: Reactome:REACT_92889 "Phosphorylation of TSC2 by PKB, Sus scrofa"
xref: Reactome:REACT_92915 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Danio rerio"
xref: Reactome:REACT_92929 "RAF1 phosphorylates MEK1, Danio rerio"
xref: Reactome:REACT_92951 "Phosphorylation and activation of Chk1 by ATM, Canis familiaris"
xref: Reactome:REACT_93018 "RAF1 phosphorylates MEK1, Bos taurus"
xref: Reactome:REACT_93105 "Phosphorylation of cPLA2 by ERK-2, Rattus norvegicus"
xref: Reactome:REACT_93124 "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes, Mus musculus"
xref: Reactome:REACT_93149 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Dictyostelium discoideum"
xref: Reactome:REACT_93166 "Phosphorylation and activation of Chk1 by ATM, Taeniopygia guttata"
xref: Reactome:REACT_93219 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta, Xenopus tropicalis"
xref: Reactome:REACT_93221 "Phosphoryation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3, Xenopus tropicalis"
xref: Reactome:REACT_93346 "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes, Mus musculus"
xref: Reactome:REACT_93366 "Phosphorylation of cPLA2 by ERK-2, Canis familiaris"
xref: Reactome:REACT_93414 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Drosophila melanogaster"
xref: Reactome:REACT_93440 "Regulation of KIF20A (MKL2) by phosphorylation, Taeniopygia guttata"
xref: Reactome:REACT_93441 "Regulation of KIF23 (MKLP1) by phosphorylation, Gallus gallus"
xref: Reactome:REACT_93613 "CAK-mediated phosphorylation of Cyclin A:Cdk2, Rattus norvegicus"
xref: Reactome:REACT_93615 "Phosphorylation of MDM2 at serine-395 by ATM kinase, Bos taurus"
xref: Reactome:REACT_937 "Phosphorylation of BRCA1 at multiple sites by ATM, Homo sapiens"
xref: Reactome:REACT_93706 "RAF1 phosphorylates MEK1, Canis familiaris"
xref: Reactome:REACT_93746 "Phosphorylation of Cyclin A:Cdk2 at Tyr 15, Mus musculus"
xref: Reactome:REACT_93878 "Phosphorylation of Cdc25A at Ser-123 in response to DNA damage, Gallus gallus"
xref: Reactome:REACT_94017 "SOS phosphorylation and dissociation (IRS, Crk), Bos taurus"
xref: Reactome:REACT_94113 "Phosphorylation of Cx43 by c-src, Canis familiaris"
xref: Reactome:REACT_94151 "Phosphorylation of Wee1 kinase by Chk1, Xenopus tropicalis"
xref: Reactome:REACT_94248 "SOS phosphorylation and dissociation (SHC), Bos taurus"
xref: Reactome:REACT_94258 "Phosphorylation of p53 at ser-15 by ATM kinase, Sus scrofa"
xref: Reactome:REACT_94298 "Phosphorylation of Cyclin B1 in the CRS domain, Danio rerio"
xref: Reactome:REACT_94397 "Orc1 is phosphorylated by cyclin A/CDK2, Danio rerio"
xref: Reactome:REACT_94428 "Phosphorylation of PD-1, Bos taurus"
xref: Reactome:REACT_94452 "Phosphorylation of MDC1/NFBD1 by ATM (within 2 c-term BRCT domains), Bos taurus"
xref: Reactome:REACT_94464 "Phosphorylation and activation of eIF4B by activated S6K1, Danio rerio"
xref: Reactome:REACT_94562 "Phosphorylation of the Scc1:Cohesion Complex, Caenorhabditis elegans"
xref: Reactome:REACT_94615 "SOS phosphorylation and dissociation (IRS, Crk), Rattus norvegicus"
xref: Reactome:REACT_94784 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta, Rattus norvegicus"
xref: Reactome:REACT_94817 "Phosphorylation of the SA2 Cohesin Complex, Rattus norvegicus"
xref: Reactome:REACT_94947 "Autophosphorylation of PAK-2p34 in the activation loop, Canis familiaris"
xref: Reactome:REACT_95052 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Oryza sativa"
xref: Reactome:REACT_95087 "Phosphorylation of the Scc1:Cohesion Complex, Bos taurus"
xref: Reactome:REACT_95088 "Inactivation of Wee1 kinase, Mus musculus"
xref: Reactome:REACT_95089 "Phosphorylation of Cyclin E:Cdk2 complexes by Wee-1, Bos taurus"
xref: Reactome:REACT_95155 "Regulation of NUDC by phosphorylation, Taeniopygia guttata"
xref: Reactome:REACT_95163 "CAK-mediated phosphorylation of Cyclin A:Cdk2, Mus musculus"
xref: Reactome:REACT_95437 "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3, Drosophila melanogaster"
xref: Reactome:REACT_95461 "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2, Bos taurus"
xref: Reactome:REACT_95504 "Phosphorylation of Cdc25C at Ser216, Xenopus tropicalis"
xref: Reactome:REACT_95769 "PIP2 conversion to PIP3, Xenopus tropicalis"
xref: Reactome:REACT_96 "Phosphorylation of Cyclin D:Cdk4/6 complexes, Homo sapiens"
xref: Reactome:REACT_96039 "Myt-1 mediated phosphorylation of Cyclin A:Cdc2, Canis familiaris"
xref: Reactome:REACT_96088 "Phosphorylation of PDE3B, Sus scrofa"
xref: Reactome:REACT_96097 "SOS phosphorylation and dissociation (IRS), Rattus norvegicus"
xref: Reactome:REACT_96102 "Phosphorylation of Cx43 by c-src, Gallus gallus"
xref: Reactome:REACT_96129 "Phosphorylation and activation of eIF4G by activated S6K1, Taeniopygia guttata"
xref: Reactome:REACT_96200 "Regulation of NUDC by phosphorylation, Gallus gallus"
xref: Reactome:REACT_96208 "Phosphorylation of COP1 at Ser-387 by ATM, Sus scrofa"
xref: Reactome:REACT_96218 "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes, Drosophila melanogaster"
xref: Reactome:REACT_96356 "Free APC/C phosphorylated by Plk1, Rattus norvegicus"
xref: Reactome:REACT_96461 "Phosphorylation of L1 by CK-II, Bos taurus"
xref: Reactome:REACT_96468 "Autophosphorylation of PAK-2p34 in the activation loop, Mus musculus"
xref: Reactome:REACT_96483 "Phosphorylation of COP1 at Ser-387 by ATM, Gallus gallus"
xref: Reactome:REACT_96500 "RAF1 phosphorylates MEK2, Gallus gallus"
xref: Reactome:REACT_96524 "Activation of Cdc25C, Xenopus tropicalis"
xref: Reactome:REACT_96656 "Plk1-mediated phosphorylation of Nlp, Rattus norvegicus"
xref: Reactome:REACT_96666 "Phosphorylation and activation of CHK2 by ATM, Saccharomyces cerevisiae"
xref: Reactome:REACT_96758 "Phosphorylation of Cdc25A at Ser-123 by Chk2, Canis familiaris"
xref: Reactome:REACT_96793 "Activation of S6K1, Danio rerio"
xref: Reactome:REACT_96797 "CAK-mediated phosphorylation of Cyclin E:Cdk2, Rattus norvegicus"
xref: Reactome:REACT_96877 "Phosphorylation of MDM2 at serine-395 by ATM kinase, Sus scrofa"
xref: Reactome:REACT_96899 "Phosphorylation of TSC2 by PKB, Rattus norvegicus"
xref: Reactome:REACT_96968 "Cdc6 protein is phosphorylated by CDK, Mus musculus"
xref: Reactome:REACT_97193 "Phosphorylation and activation of eIF4G by activated S6K1, Canis familiaris"
xref: Reactome:REACT_97218 "Orc1 is phosphorylated by cyclin A/CDK2, Xenopus tropicalis"
xref: Reactome:REACT_97282 "Activation of S6K1, Sus scrofa"
xref: Reactome:REACT_97299 "Phosphorylation of Cyclin E2:Cdk2 complexes by Myt1, Mus musculus"
xref: Reactome:REACT_97458 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Dictyostelium discoideum"
xref: Reactome:REACT_97577 "Myt-1 mediated phosphorylation of Cyclin A:Cdc2, Bos taurus"
xref: Reactome:REACT_97661 "Mcm2-7 is phosphorylated by DDK, Gallus gallus"
xref: Reactome:REACT_97667 "Phosphorylation of complexed TSC2 by PKB, Canis familiaris"
xref: Reactome:REACT_97748 "Phosphorylation of cPLA2 by ERK-2, Mus musculus"
xref: Reactome:REACT_97759 "Phosphorylation of Cx43 by c-src, Danio rerio"
xref: Reactome:REACT_97847 "Phosphorylation of Cdc25A at Ser-123 by Chk2, Mus musculus"
xref: Reactome:REACT_97905 "Phosphorylation of BRCA1 at multiple sites by ATM, Xenopus tropicalis"
xref: Reactome:REACT_98024 "Myt-1 mediated phosphorylation of Cyclin A:Cdc2, Mus musculus"
xref: Reactome:REACT_98050 "Phosphorylation of Cdc25C at Ser216, Canis familiaris"
xref: Reactome:REACT_98066 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Saccharomyces cerevisiae"
xref: Reactome:REACT_98109 "Regulation of NUDC by phosphorylation, Mus musculus"
xref: Reactome:REACT_98176 "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3, Bos taurus"
xref: Reactome:REACT_98213 "Phosphorylation of Cdc25A at Ser-123 in response to DNA damage, Xenopus tropicalis"
xref: Reactome:REACT_98253 "RAF1 phosphorylates MEK2, Bos taurus"
xref: Reactome:REACT_98296 "Phosphorylation of Cyclin B1 in the CRS domain, Drosophila melanogaster"
xref: Reactome:REACT_98373 "Myt-1 mediated phosphorylation of Cyclin A:Cdc2, Drosophila melanogaster"
xref: Reactome:REACT_98378 "Phosphorylation of COP1 at Ser-387 by ATM, Danio rerio"
xref: Reactome:REACT_98395 "Phosphorylation and activation of Chk1 by ATM, Arabidopsis thaliana"
xref: Reactome:REACT_98434 "Phosphorylation and inactivation of eEF2K by activated S6K1, Taeniopygia guttata"
xref: Reactome:REACT_98436 "Phosphorylation of 4E-BP1 by activated mTORC1, Gallus gallus"
xref: Reactome:REACT_98443 "Inactivation of Wee1 kinase, Gallus gallus"
xref: Reactome:REACT_98493 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Drosophila melanogaster"
xref: Reactome:REACT_98558 "Autophosphorylation of PAK-2p34 in the activation loop, Saccharomyces cerevisiae"
xref: Reactome:REACT_98560 "Phosphorylation and activation of CHK2 by ATM, Xenopus tropicalis"
xref: Reactome:REACT_98663 "Regulation of KIF23 (MKLP1) by phosphorylation, Bos taurus"
xref: Reactome:REACT_98708 "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3, Drosophila melanogaster"
xref: Reactome:REACT_98731 "Phosphorylation of Cdc25A at Ser-123 by Chk1, Danio rerio"
xref: Reactome:REACT_98738 "Phosphorylation of TSC2 by PKB, Danio rerio"
xref: Reactome:REACT_98741 "Phosphorylation of beta-catenin at Ser45 by CK1 alpha, Bos taurus"
xref: Reactome:REACT_98779 "Phosphorylation of Cx43 by c-src, Taeniopygia guttata"
xref: Reactome:REACT_988 "Phosphorylation of MDM2 at serine-395 by ATM kinase, Homo sapiens"
xref: Reactome:REACT_98847 "Phosphorylation of complexed TSC2 by PKB, Mus musculus"
xref: Reactome:REACT_98908 "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3, Rattus norvegicus"
xref: Reactome:REACT_98913 "Phosphorylation of PD-1, Canis familiaris"
xref: Reactome:REACT_98971 "Phosphorylation of AKT2 by PDK1, Rattus norvegicus"
xref: Reactome:REACT_98996 "Free APC/C phosphorylated by Plk1, Danio rerio"
xref: Reactome:REACT_99025 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Taeniopygia guttata"
xref: Reactome:REACT_99053 "CAK-mediated phosphorylation of Cyclin E:Cdk2, Sus scrofa"
xref: Reactome:REACT_99141 "Phosphorylation of NBS1 by ATM, Bos taurus"
xref: Reactome:REACT_99158 "Inactivation of Wee1 kinase, Drosophila melanogaster"
xref: Reactome:REACT_99207 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Taeniopygia guttata"
xref: Reactome:REACT_99231 "Phosphorylation of AKT2 by PDK1, Danio rerio"
xref: Reactome:REACT_99266 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Caenorhabditis elegans"
xref: Reactome:REACT_99302 "Phosphorylation of Cyclin D:Cdk4/6 complexes, Sus scrofa"
xref: Reactome:REACT_99311 "RAF1 phosphorylates MEK1, Mus musculus"
xref: Reactome:REACT_9955 "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3, Homo sapiens"
xref: Reactome:REACT_99556 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Mus musculus"
xref: Reactome:REACT_99560 "RAF1 phosphorylates MEK2, Canis familiaris"
xref: Reactome:REACT_9959 "Phosphoryation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3, Homo sapiens"
xref: Reactome:REACT_99595 "Phosphorylation of Cyclin A:Cdk2 at Tyr 15, Bos taurus"
xref: Reactome:REACT_99713 "Phosphorylation of DLC2 by MAPK-8, Taeniopygia guttata"
xref: Reactome:REACT_9978 "Phosphorylation of beta-catenin at Ser45 by CK1 alpha, Homo sapiens"
xref: Reactome:REACT_99785 "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3, Canis familiaris"
xref: Reactome:REACT_9983 "Phosphorylation of APC component of the destruction complex, Homo sapiens"
xref: Reactome:REACT_9987 "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3, Homo sapiens"
xref: Reactome:REACT_99929 "Phosphorylation of beta-catenin at Ser45 by CK1 alpha, Gallus gallus"
xref: Reactome:REACT_99966 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Schizosaccharomyces pombe"
xref: Reactome:REACT_9997 "Phosphorylation of Cx43 by c-src, Homo sapiens"
is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups
relationship: part_of GO:0016310 ! phosphorylation

[Term]
id: GO:0016303
name: 1-phosphatidylinositol-3-kinase activity
namespace: molecular_function
alt_id: GO:0004429
def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H(+)." [EC:2.7.1.137, RHEA:12712]
synonym: "1-phosphatidylinositol 3-kinase activity" EXACT []
synonym: "ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase activity" EXACT [EC:2.7.1.137]
synonym: "phosphatidylinositol 3-kinase activity, class I" NARROW []
synonym: "phosphatidylinositol 3-kinase activity, class II" NARROW []
synonym: "phosphatidylinositol 3-kinase activity, class III" NARROW []
synonym: "phosphatidylinositol 3-kinase, class I, catalyst activity" NARROW []
synonym: "PI3-kinase activity" EXACT [EC:2.7.1.137]
synonym: "PI3K" EXACT []
synonym: "PtdIns-3-kinase activity" EXACT [EC:2.7.1.137]
synonym: "type I phosphatidylinositol kinase activity" NARROW [EC:2.7.1.137]
synonym: "type III phosphoinositide 3-kinase activity" NARROW [EC:2.7.1.137]
synonym: "Vps34p" RELATED [EC:2.7.1.137]
xref: EC:2.7.1.137
xref: KEGG:R03362
xref: MetaCyc:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN
xref: RHEA:12712
is_a: GO:0035004 ! phosphatidylinositol 3-kinase activity
is_a: GO:0052742 ! phosphatidylinositol kinase activity
relationship: part_of GO:0036092 ! phosphatidylinositol-3-phosphate biosynthetic process

[Term]
id: GO:0016304
name: obsolete phosphatidylinositol 3-kinase activity, class I
namespace: molecular_function
def: "OBSOLETE. A heterodimeric phosphoinositide 3-kinase which can phosphorylate phosphatidylinositol, phosphatidylinositol-4-phosphate or phosphatidylinositol-4,5-bisphosphate. Also possesses intrinsic protein kinase activity." [PMID:9759495]
comment: This term was made obsolete because it represents a class of gene products.
synonym: "phosphatidylinositol 3-kinase activity, class I" EXACT []
is_obsolete: true
consider: GO:0016303
consider: GO:0035005
consider: GO:0046934

[Term]
id: GO:0016305
name: obsolete phosphatidylinositol 3-kinase activity, class II
namespace: molecular_function
def: "OBSOLETE. A phosphoinositide 3-kinase which can phosphorylate phosphatidylinositol and phosphatidylinositol-4-phosphate; the human form can phosphorylate phosphatidylinositol-4,5-bisphosphate in the presence of phosphatidylserine." [PMID:9759495]
comment: This term was made obsolete because it represents a class of gene products.
synonym: "phosphatidylinositol 3-kinase activity, class II" EXACT []
synonym: "PI3KC2" EXACT []
is_obsolete: true
consider: GO:0016303
consider: GO:0035005
consider: GO:0046934

[Term]
id: GO:0016306
name: obsolete phosphatidylinositol 3-kinase activity, class III
namespace: molecular_function
def: "OBSOLETE. A phosphoinositide 3-kinase which can only phosphorylate phosphatidylinositol." [PMID:9759495]
comment: This term was made obsolete because it represents a class of gene products.
synonym: "phosphatidylinositol 3-kinase activity, class III" EXACT []
is_obsolete: true
replaced_by: GO:0016303

[Term]
id: GO:0016307
name: phosphatidylinositol phosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + a phosphatidylinositol phosphate = ADP + a phosphatidylinositol bisphosphate." [EC:2.7.1.-, PMID:9759495]
subset: gosubset_prok
synonym: "phosphatidylinositol monophosphate kinase activity" EXACT [GOC:bf]
xref: EC:2.7.1.-
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
relationship: part_of GO:0046854 ! phosphatidylinositol phosphorylation

[Term]
id: GO:0016308
name: 1-phosphatidylinositol-4-phosphate 5-kinase activity
namespace: molecular_function
alt_id: GO:0004431
alt_id: GO:0045215
def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.68, RHEA:14428]
subset: gosubset_prok
synonym: "1-phosphatidylinositol-4-phosphate kinase activity" BROAD []
synonym: "1-phosphatidylinositol-4-phosphate kinase, class IA" NARROW []
synonym: "1-phosphatidylinositol-4-phosphate kinase, class IB" NARROW []
synonym: "ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 5-phosphotransferase activity" EXACT [EC:2.7.1.68]
synonym: "diphosphoinositide kinase activity" BROAD [EC:2.7.1.68]
synonym: "phosphatidylinositol 4-phosphate kinase activity" BROAD [EC:2.7.1.68]
synonym: "phosphatidylinositol-4-phosphate 5-kinase activity" EXACT [EC:2.7.1.68]
synonym: "PIP kinase activity" BROAD [EC:2.7.1.68]
synonym: "PIP5K" EXACT []
synonym: "PtdIns(4)P-5-kinase activity" EXACT [EC:2.7.1.68]
synonym: "type I PIP kinase activity" NARROW [EC:2.7.1.68]
xref: EC:2.7.1.68
xref: KEGG:R03469
xref: MetaCyc:2.7.1.68-RXN
xref: RHEA:14428
is_a: GO:0016307 ! phosphatidylinositol phosphate kinase activity

[Term]
id: GO:0016309
name: 1-phosphatidylinositol-5-phosphate 4-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate." [EC:2.7.1.149]
synonym: "1-phosphatidylinositol-5-phosphate kinase" BROAD []
synonym: "ATP:1-phosphatidyl-1D-myo-inositol-5-phosphate 4-phosphotransferase activity" EXACT [EC:2.7.1.149]
synonym: "PIP4K" EXACT []
synonym: "type II PIP kinase activity" NARROW [EC:2.7.1.149]
xref: EC:2.7.1.149
xref: MetaCyc:2.7.1.149-RXN
xref: RHEA:12283
is_a: GO:0016307 ! phosphatidylinositol phosphate kinase activity

[Term]
id: GO:0016310
name: phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732]
subset: goslim_chembl
subset: goslim_metagenomics
subset: gosubset_prok
xref: Wikipedia:Phosphorylation
is_a: GO:0006796 ! phosphate-containing compound metabolic process

[Term]
id: GO:0016311
name: dephosphorylation
namespace: biological_process
def: "The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]
subset: gosubset_prok
xref: Wikipedia:Dephosphorylation
is_a: GO:0006796 ! phosphate-containing compound metabolic process

[Term]
id: GO:0016312
name: inositol bisphosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: myo-inositol bisphosphate + H2O = myo-inositol phosphate + phosphate." [GOC:hb]
xref: EC:3.1.3.-
is_a: GO:0052745 ! inositol phosphate phosphatase activity

[Term]
id: GO:0016313
name: obsolete inositol-1,4,5-trisphosphate phosphatase
namespace: molecular_function
def: "OBSOLETE. The removal of one of the phosphate groups from an inositol triphosphate to produce an inositol bisphosphate." [GOC:hb]
comment: This term was made obsolete because it is a redundant grouping term with only one child.
synonym: "inositol-1,4,5-trisphosphate phosphatase" EXACT []
is_obsolete: true
consider: GO:0046030

[Term]
id: GO:0016314
name: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidylinositol-4,5-bisphosphate + phosphate." [EC:3.1.3.67]
synonym: "1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 3-phosphohydrolase activity" EXACT [EC:3.1.3.67]
synonym: "MMAC1" RELATED [EC:3.1.3.67]
synonym: "phosphatidylinositol-3,4,5-trisphosphate 3-phosphohydrolase activity" EXACT [EC:3.1.3.67]
xref: EC:3.1.3.67
xref: MetaCyc:3.1.3.67-RXN
xref: Reactome:REACT_101176 "Hydrolysis of PIP3 to PI(3,4)P2, Rattus norvegicus"
xref: Reactome:REACT_101572 "Hydrolysis of PIP3 to PIP2, Bos taurus"
xref: Reactome:REACT_101687 "Hydrolysis of PIP3 to PIP2, Taeniopygia guttata"
xref: Reactome:REACT_103500 "PTEN dephosphorylates PIP3, Caenorhabditis elegans"
xref: Reactome:REACT_103799 "Hydrolysis of PIP3 to PI(3,4)P2, Canis familiaris"
xref: Reactome:REACT_104388 "PTEN dephosphorylates PIP3, Oryza sativa"
xref: Reactome:REACT_105029 "Hydrolysis of PIP3 to PIP2, Rattus norvegicus"
xref: Reactome:REACT_107191 "PTEN dephosphorylates PIP3, Bos taurus"
xref: Reactome:REACT_108932 "Hydrolysis of PIP3 to PIP2, Drosophila melanogaster"
xref: Reactome:REACT_109496 "Hydrolysis of PIP3 to PI(3,4)P2, Sus scrofa"
xref: Reactome:REACT_114681 "Hydrolysis of PIP3 to PIP2, Dictyostelium discoideum"
xref: Reactome:REACT_115120 "PTEN dephosphorylates PIP3, Dictyostelium discoideum"
xref: Reactome:REACT_12405 "Hydrolysis of PIP3 to PI(3,4)P2, Homo sapiens"
xref: Reactome:REACT_12542 "PTEN dephosphorylates PIP3, Homo sapiens"
xref: Reactome:REACT_12545 "Hydrolysis of PIP3 to PIP2, Homo sapiens"
xref: Reactome:REACT_29394 "Hydrolysis of PIP3 to PIP2, Mus musculus"
xref: Reactome:REACT_29414 "PTEN dephosphorylates PIP3, Danio rerio"
xref: Reactome:REACT_29428 "Hydrolysis of PIP3 to PI(3,4)P2, Danio rerio"
xref: Reactome:REACT_29671 "Hydrolysis of PIP3 to PIP2, Danio rerio"
xref: Reactome:REACT_34577 "Hydrolysis of PIP3 to PI(3,4)P2, Gallus gallus"
xref: Reactome:REACT_6317 "PIP3 dephosphorylated to PIP2 by DPTEN, Drosophila melanogaster"
xref: Reactome:REACT_78743 "Hydrolysis of PIP3 to PI(3,4)P2, Bos taurus"
xref: Reactome:REACT_79337 "Hydrolysis of PIP3 to PIP2, Gallus gallus"
xref: Reactome:REACT_79774 "Hydrolysis of PIP3 to PIP2, Xenopus tropicalis"
xref: Reactome:REACT_82001 "Hydrolysis of PIP3 to PIP2, Sus scrofa"
xref: Reactome:REACT_83943 "Hydrolysis of PIP3 to PIP2, Canis familiaris"
xref: Reactome:REACT_86223 "PTEN dephosphorylates PIP3, Arabidopsis thaliana"
xref: Reactome:REACT_86271 "PTEN dephosphorylates PIP3, Sus scrofa"
xref: Reactome:REACT_86859 "PTEN dephosphorylates PIP3, Drosophila melanogaster"
xref: Reactome:REACT_87616 "Hydrolysis of PIP3 to PI(3,4)P2, Xenopus tropicalis"
xref: Reactome:REACT_88261 "PTEN dephosphorylates PIP3, Xenopus tropicalis"
xref: Reactome:REACT_88506 "Hydrolysis of PIP3 to PIP2, Caenorhabditis elegans"
xref: Reactome:REACT_92643 "Hydrolysis of PIP3 to PI(3,4)P2, Mus musculus"
xref: Reactome:REACT_92999 "Hydrolysis of PIP3 to PIP2, Oryza sativa"
xref: Reactome:REACT_93904 "Hydrolysis of PIP3 to PI(3,4)P2, Dictyostelium discoideum"
xref: Reactome:REACT_94887 "PTEN dephosphorylates PIP3, Gallus gallus"
xref: Reactome:REACT_95009 "PTEN dephosphorylates PIP3, Rattus norvegicus"
xref: Reactome:REACT_96755 "PTEN dephosphorylates PIP3, Canis familiaris"
xref: Reactome:REACT_97317 "PTEN dephosphorylates PIP3, Mus musculus"
xref: Reactome:REACT_98116 "Hydrolysis of PIP3 to PIP2, Arabidopsis thaliana"
xref: Reactome:REACT_98445 "PTEN dephosphorylates PIP3, Taeniopygia guttata"
xref: Reactome:REACT_99891 "Hydrolysis of PIP3 to PI(3,4)P2, Taeniopygia guttata"
xref: RHEA:25020
is_a: GO:0034594 ! phosphatidylinositol trisphosphate phosphatase activity

[Term]
id: GO:0016316
name: phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity
namespace: molecular_function
alt_id: GO:0004440
def: "Catalysis of the reaction: 1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate." [EC:3.1.3.66, GOC:hb]
synonym: "1-phosphatidyl-1D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase activity" EXACT [EC:3.1.3.66]
synonym: "inositol polyphosphate 4-phosphatase type II activity" RELATED [EC:3.1.3.66]
xref: EC:3.1.3.66
xref: MetaCyc:3.1.3.66-RXN
is_a: GO:0034593 ! phosphatidylinositol bisphosphate phosphatase activity
is_a: GO:0034596 ! phosphatidylinositol phosphate 4-phosphatase activity
relationship: part_of GO:0036092 ! phosphatidylinositol-3-phosphate biosynthetic process

[Term]
id: GO:0016318
name: ommatidial rotation
namespace: biological_process
def: "The process in which photoreceptors are arranged in ommatidia in the dorsal and ventral fields to be mirror images. The polarity is established in the imaginal discs concurrently with cell fate specification." [PMID:10725247]
is_a: GO:0007389 ! pattern specification process
relationship: part_of GO:0042067 ! establishment of ommatidial planar polarity

[Term]
id: GO:0016319
name: mushroom body development
namespace: biological_process
def: "The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007420 ! brain development

[Term]
id: GO:0016320
name: endoplasmic reticulum membrane fusion
namespace: biological_process
def: "The joining of 2 or more lipid bilayer membranes that surround the endoplasmic reticulum." [GOC:elh, GOC:jid]
synonym: "ER membrane fusion" EXACT []
is_a: GO:0090174 ! organelle membrane fusion

[Term]
id: GO:0016321
name: female meiosis chromosome segregation
namespace: biological_process
def: "The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female." [GOC:ai]
is_a: GO:0045132 ! meiotic chromosome segregation
intersection_of: GO:0098813 ! nuclear chromosome segregation
intersection_of: part_of GO:0007143 ! female meiotic division
relationship: part_of GO:0007143 ! female meiotic division

[Term]
id: GO:0016322
name: neuron remodeling
namespace: biological_process
def: "The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development." [GOC:hb]
synonym: "axon pruning" NARROW [GOC:sart, PMID:18267091]
synonym: "neuronal remodeling" EXACT []
is_a: GO:0042551 ! neuron maturation

[Term]
id: GO:0016323
name: basolateral plasma membrane
namespace: cellular_component
def: "The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]
is_a: GO:0098590 ! plasma membrane region
relationship: part_of GO:0005886 ! plasma membrane

[Term]
id: GO:0016324
name: apical plasma membrane
namespace: cellular_component
def: "The region of the plasma membrane located at the apical end of the cell." [GOC:curators]
is_a: GO:0098590 ! plasma membrane region
relationship: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0045177 ! apical part of cell

[Term]
id: GO:0016325
name: oocyte microtubule cytoskeleton organization
namespace: biological_process
alt_id: GO:0048130
def: "Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11231123]
synonym: "oocyte microtubule cytoskeleton organisation" EXACT [GOC:curators]
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0030951 ! establishment or maintenance of microtubule cytoskeleton polarity
relationship: part_of GO:0007308 ! oocyte construction

[Term]
id: GO:0016326
name: obsolete kinesin motor activity
namespace: molecular_function
def: "OBSOLETE. The hydrolysis of ATP (and GTP) that drives the microtubular motor along microtubules." [GOC:hb]
comment: This term was made obsolete because it represents a gene product.
synonym: "kinesin motor activity" EXACT []
is_obsolete: true
replaced_by: GO:0003777

[Term]
id: GO:0016327
name: apicolateral plasma membrane
namespace: cellular_component
def: "The apical end of the lateral plasma membrane of epithelial cells." [GOC:hb]
synonym: "apical lateral plasma membrane" EXACT [PMID:24496625]
is_a: GO:0098590 ! plasma membrane region
relationship: part_of GO:0005886 ! plasma membrane

[Term]
id: GO:0016328
name: lateral plasma membrane
namespace: cellular_component
def: "The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells." [GOC:hb, GOC:mah, GOC:pr]
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0016329
name: obsolete apoptosis regulator activity
namespace: molecular_function
def: "OBSOLETE. The function held by products which directly regulate any step in the process of apoptosis." [GOC:jl]
comment: This term was made obsolete because it represents involvement in a biological process.
synonym: "apoptosis regulator activity" EXACT []
is_obsolete: true
replaced_by: GO:0042981

[Term]
id: GO:0016330
name: second mitotic wave involved in compound eye morphogenesis
namespace: biological_process
def: "A discrete cell cycle in the third instar eye imaginal disc after progression of the morphogenetic furrow that contributes to compound eye morphogenesis. It is essential for generation of a sufficient pool of uncommitted cells to develop complete ommatidia." [PMID:11257224]
synonym: "second mitotic wave during compound eye morphogenesis" RELATED [GOC:dph, GOC:tb]
is_a: GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0001745 ! compound eye morphogenesis

[Term]
id: GO:0016331
name: morphogenesis of embryonic epithelium
namespace: biological_process
def: "The process in which the anatomical structures of embryonic epithelia are generated and organized." [GOC:jl]
is_a: GO:0002009 ! morphogenesis of an epithelium
is_a: GO:0048598 ! embryonic morphogenesis

[Term]
id: GO:0016332
name: establishment or maintenance of polarity of embryonic epithelium
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization of epithelial cells in an embryo." [GOC:isa_complete, GOC:mah]
is_a: GO:0007163 ! establishment or maintenance of cell polarity
relationship: part_of GO:0016331 ! morphogenesis of embryonic epithelium

[Term]
id: GO:0016333
name: morphogenesis of follicular epithelium
namespace: biological_process
def: "The process in which the anatomical structures of a follicular epithelium are generated and organized." [GOC:jl]
is_a: GO:0002009 ! morphogenesis of an epithelium

[Term]
id: GO:0016334
name: establishment or maintenance of polarity of follicular epithelium
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of a polarized follicular epithelial sheet." [GOC:bf, GOC:mah]
is_a: GO:0007163 ! establishment or maintenance of cell polarity
relationship: part_of GO:0016333 ! morphogenesis of follicular epithelium

[Term]
id: GO:0016335
name: morphogenesis of larval imaginal disc epithelium
namespace: biological_process
def: "The process in which the anatomical structures of a larval imaginal disc epithelium are generated and organized." [GOC:jl]
is_a: GO:0002009 ! morphogenesis of an epithelium
is_a: GO:0009886 ! post-embryonic morphogenesis
relationship: part_of GO:0002168 ! instar larval development
relationship: part_of GO:0007560 ! imaginal disc morphogenesis

[Term]
id: GO:0016336
name: establishment or maintenance of polarity of larval imaginal disc epithelium
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of a polarized larval imaginal disc epithelium." [GOC:jl, GOC:mah]
is_a: GO:0007163 ! establishment or maintenance of cell polarity
relationship: part_of GO:0016335 ! morphogenesis of larval imaginal disc epithelium

[Term]
id: GO:0016337
name: single organismal cell-cell adhesion
namespace: biological_process
def: "The attachment of one cell to another cell via adhesion molecules, where both cells are part of the same organism." [GOC:hb]
subset: gosubset_prok
is_a: GO:0098602 ! single organism cell adhesion
is_a: GO:0098609 ! cell-cell adhesion

[Term]
id: GO:0016338
name: calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
namespace: biological_process
def: "The attachment of one cell to another cell via adhesion molecules that do not require the presence of calcium for the interaction." [GOC:hb]
synonym: "calcium-independent cell adhesion molecule activity" RELATED []
is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules

[Term]
id: GO:0016339
name: calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
namespace: biological_process
def: "The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction." [GOC:hb]
synonym: "calcium-dependent cell adhesion molecule activity" RELATED []
is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules

[Term]
id: GO:0016340
name: calcium-dependent cell-matrix adhesion
namespace: biological_process
def: "The binding of a cell to the extracellular matrix via adhesion molecules that require the presence of calcium for the interaction." [GOC:hb]
is_a: GO:0007160 ! cell-matrix adhesion

[Term]
id: GO:0016341
name: obsolete other collagen
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it is a redundant grouping term.
synonym: "other collagen" EXACT []
is_obsolete: true
replaced_by: GO:0005581

[Term]
id: GO:0016342
name: catenin complex
namespace: cellular_component
def: "Complex of peripheral cytoplasmic proteins (alpha-, beta- and gamma-catenin) that interact with the cytoplasmic region of uvomorulin/E-cadherin to connect it to the actin cytoskeleton." [ISBN:0198599323]
is_a: GO:0098797 ! plasma membrane protein complex
relationship: part_of GO:0019897 ! extrinsic component of plasma membrane

[Term]
id: GO:0016343
name: obsolete cytoskeletal anchoring activity
namespace: molecular_function
def: "OBSOLETE. The direct or indirect linkage of cytoskeletal filaments to the plasma membrane." [ISBN:0198599323]
comment: This term was made obsolete because it represents a biological process.
synonym: "cytoskeletal anchoring activity" EXACT []
is_obsolete: true
replaced_by: GO:0007016

[Term]
id: GO:0016344
name: meiotic chromosome movement towards spindle pole
namespace: biological_process
def: "The cell cycle process in which the directed movement of chromosomes from the center of the spindle towards the spindle poles takes place, mediated by the shortening of microtubules attached to the chromosomes. This occurs during meiosis." [GOC:ai]
synonym: "chromosome migration to spindle pole during meiosis" EXACT []
synonym: "chromosome movement towards spindle pole during meiosis" EXACT []
synonym: "meiotic chromosome movement" BROAD []
synonym: "meiotic chromosome movement to spindle pole" EXACT []
is_a: GO:0051305 ! chromosome movement towards spindle pole
is_a: GO:1903046 ! meiotic cell cycle process
intersection_of: GO:0051305 ! chromosome movement towards spindle pole
intersection_of: part_of GO:0051321 ! meiotic cell cycle
relationship: part_of GO:0045132 ! meiotic chromosome segregation
relationship: part_of GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0016345
name: female meiotic chromosome movement towards spindle pole
namespace: biological_process
def: "The directed movement of chromosomes in the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during female meiosis." [GOC:ai]
synonym: "chromosome movement towards spindle pole during female meiosis" EXACT []
synonym: "female meiotic chromosome movement" BROAD []
synonym: "female meiotic chromosome movement to spindle pole" EXACT []
is_a: GO:0016344 ! meiotic chromosome movement towards spindle pole
intersection_of: GO:0051305 ! chromosome movement towards spindle pole
intersection_of: part_of GO:0007143 ! female meiotic division
relationship: part_of GO:0007143 ! female meiotic division
relationship: part_of GO:0016321 ! female meiosis chromosome segregation

[Term]
id: GO:0016346
name: male meiotic chromosome movement towards spindle pole
namespace: biological_process
def: "The directed movement of chromosomes in the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during male meiosis." [GOC:ai]
synonym: "chromosome movement towards spindle pole during male meiosis" EXACT []
synonym: "male meiotic chromosome movement" BROAD []
synonym: "male meiotic chromosome movement to spindle pole" EXACT []
is_a: GO:0016344 ! meiotic chromosome movement towards spindle pole
intersection_of: GO:0051305 ! chromosome movement towards spindle pole
intersection_of: part_of GO:0007140 ! male meiosis
relationship: part_of GO:0007060 ! male meiosis chromosome segregation
relationship: part_of GO:0007140 ! male meiosis

[Term]
id: GO:0016347
name: obsolete calcium-independent cell adhesion molecule activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "calcium-independent cell adhesion molecule activity" EXACT []
is_obsolete: true
consider: GO:0005515
consider: GO:0007161
consider: GO:0016021
consider: GO:0016338

[Term]
id: GO:0016348
name: imaginal disc-derived leg joint morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of an imaginal disc-derived leg joint are generated and organized. The leg joint is a flexible region that separates the rigid sections of a leg to allow movement in a controlled manner. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
is_a: GO:0009886 ! post-embryonic morphogenesis
relationship: part_of GO:0036011 ! imaginal disc-derived leg segmentation

[Term]
id: GO:0016351
name: obsolete drug susceptibility/resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process.
synonym: "drug susceptibility/resistance" EXACT []
is_obsolete: true
replaced_by: GO:0042493

[Term]
id: GO:0016352
name: obsolete insecticide susceptibility/resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process.
synonym: "insecticide susceptibility/resistance" EXACT []
is_obsolete: true
replaced_by: GO:0017085

[Term]
id: GO:0016353
name: obsolete carbamate susceptibility/resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process.
synonym: "carbamate susceptibility/resistance" EXACT []
is_obsolete: true
replaced_by: GO:0046681

[Term]
id: GO:0016354
name: obsolete cyclodiene susceptibility/resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process.
synonym: "cyclodiene susceptibility/resistance" EXACT []
is_obsolete: true
replaced_by: GO:0046682

[Term]
id: GO:0016355
name: obsolete DDT susceptibility/resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process.
synonym: "DDT susceptibility/resistance" EXACT []
is_obsolete: true
replaced_by: GO:0046680

[Term]
id: GO:0016356
name: obsolete organophosphorus susceptibility/resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process.
synonym: "organophosphorus susceptibility/resistance" EXACT []
is_obsolete: true
replaced_by: GO:0046683

[Term]
id: GO:0016357
name: obsolete pyrethroid susceptibility/resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process.
synonym: "pyrethroid susceptibility/resistance" EXACT []
is_obsolete: true
replaced_by: GO:0046684

[Term]
id: GO:0016358
name: dendrite development
namespace: biological_process
def: "The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
is_a: GO:0031175 ! neuron projection development
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development

[Term]
id: GO:0016360
name: sensory organ precursor cell fate determination
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a sensory organ precursor cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators]
synonym: "sense organ precursor cell fate determination" EXACT [GOC:dph]
is_a: GO:0060582 ! cell fate determination involved in pattern specification
relationship: part_of GO:0008052 ! sensory organ boundary specification

[Term]
id: GO:0016361
name: activin receptor activity, type I
namespace: molecular_function
def: "Combining with activin-bound type II activin receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of activin signals." [GOC:mah, PMID:8622651]
synonym: "type I activin receptor activity" EXACT []
is_a: GO:0017002 ! activin-activated receptor activity

[Term]
id: GO:0016362
name: activin receptor activity, type II
namespace: molecular_function
def: "Combining with activin to initiate a change in cell activity; upon ligand binding, binds to and catalyses the phosphorylation of a type I activin receptor." [GOC:mah, PMID:8622651]
synonym: "type II activin receptor activity" EXACT []
xref: Reactome:REACT_100350 "Type II receptor phosphorylates type I receptor, Canis familiaris"
xref: Reactome:REACT_101179 "Type II receptor phosphorylates type I receptor, Drosophila melanogaster"
xref: Reactome:REACT_12070 "Type II receptor phosphorylates type I receptor, Homo sapiens"
xref: Reactome:REACT_77613 "Type II receptor phosphorylates type I receptor, Rattus norvegicus"
xref: Reactome:REACT_81022 "Type II receptor phosphorylates type I receptor, Danio rerio"
xref: Reactome:REACT_84244 "Type II receptor phosphorylates type I receptor, Xenopus tropicalis"
xref: Reactome:REACT_88188 "Type II receptor phosphorylates type I receptor, Bos taurus"
xref: Reactome:REACT_89803 "Type II receptor phosphorylates type I receptor, Mus musculus"
xref: Reactome:REACT_90909 "Type II receptor phosphorylates type I receptor, Gallus gallus"
xref: Reactome:REACT_91116 "Type II receptor phosphorylates type I receptor, Sus scrofa"
xref: Reactome:REACT_91261 "Type II receptor phosphorylates type I receptor, Taeniopygia guttata"
is_a: GO:0017002 ! activin-activated receptor activity

[Term]
id: GO:0016363
name: nuclear matrix
namespace: cellular_component
def: "The dense fibrillar network lying on the inner side of the nuclear membrane." [ISBN:0582227089]
synonym: "nucleoskeleton" EXACT []
xref: Wikipedia:Nuclear_matrix
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0034399 ! nuclear periphery

[Term]
id: GO:0016401
name: palmitoyl-CoA oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: palmitoyl-CoA + O2 = trans-2,3-dehydropalmitoyl-CoA + hydrogen peroxide." [GOC:jsg]
xref: EC:1.3.3.-
is_a: GO:0003997 ! acyl-CoA oxidase activity

[Term]
id: GO:0016402
name: pristanoyl-CoA oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: pristanoyl-CoA + O2 = trans-2,3-dehydropristanoyl-CoA + hydrogen peroxide." [GOC:jsg]
xref: EC:1.3.3.-
xref: Reactome:REACT_100301 "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3), Drosophila melanogaster"
xref: Reactome:REACT_100759 "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3), Sus scrofa"
xref: Reactome:REACT_101318 "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3), Rattus norvegicus"
xref: Reactome:REACT_103630 "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3), Danio rerio"
xref: Reactome:REACT_109682 "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX2), Arabidopsis thaliana"
xref: Reactome:REACT_113674 "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3), Xenopus tropicalis"
xref: Reactome:REACT_16962 "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3), Homo sapiens"
xref: Reactome:REACT_17014 "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX2), Homo sapiens"
xref: Reactome:REACT_28458 "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3), Taeniopygia guttata"
xref: Reactome:REACT_29746 "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX2), Mus musculus"
xref: Reactome:REACT_31338 "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX2), Canis familiaris"
xref: Reactome:REACT_32179 "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX2), Sus scrofa"
xref: Reactome:REACT_33268 "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX2), Xenopus tropicalis"
xref: Reactome:REACT_34211 "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX2), Bos taurus"
xref: Reactome:REACT_37318 "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX2), Gallus gallus"
xref: Reactome:REACT_79262 "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX2), Taeniopygia guttata"
xref: Reactome:REACT_85855 "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3), Canis familiaris"
xref: Reactome:REACT_86253 "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3), Bos taurus"
xref: Reactome:REACT_89092 "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3), Mus musculus"
xref: Reactome:REACT_91256 "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3), Gallus gallus"
xref: Reactome:REACT_93833 "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX2), Rattus norvegicus"
xref: Reactome:REACT_97422 "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3), Caenorhabditis elegans"
xref: Reactome:REACT_99773 "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX2), Oryza sativa"
is_a: GO:0003997 ! acyl-CoA oxidase activity

[Term]
id: GO:0016403
name: dimethylargininase activity
namespace: molecular_function
def: "Catalysis of the reaction: N(G),N(G)-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline." [EC:3.5.3.18]
subset: gosubset_prok
synonym: "dimethylarginine dimethylaminohydrolase activity" EXACT [EC:3.5.3.18]
synonym: "N(G),N(G)-dimethylarginine dimethylaminohydrolase activity" EXACT [EC:3.5.3.18]
synonym: "NG,NG-dimethyl-L-arginine dimethylamidohydrolase activity" EXACT [EC:3.5.3.18]
synonym: "NG,NG-dimethylarginine dimethylaminohydrolase activity" EXACT [EC:3.5.3.18]
xref: EC:3.5.3.18
xref: MetaCyc:DIMETHYLARGININASE-RXN
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0016404
name: 15-hydroxyprostaglandin dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NAD+ = (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADH + H+." [EC:1.1.1.141]
synonym: "(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase activity" EXACT [EC:1.1.1.141]
synonym: "11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase activity" EXACT [EC:1.1.1.141]
synonym: "15-hydroxyprostaglandin dehydrogenase activity" EXACT [EC:1.1.1.141]
synonym: "15-hydroxyprostanoic dehydrogenase activity" EXACT [EC:1.1.1.141]
synonym: "15-OH-PGDH" RELATED [EC:1.1.1.141]
synonym: "NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (type I)" EXACT [EC:1.1.1.141]
synonym: "NAD-specific 15-hydroxyprostaglandin dehydrogenase activity" EXACT [EC:1.1.1.141]
synonym: "prostaglandin dehydrogenase activity" EXACT [EC:1.1.1.141]
xref: EC:1.1.1.141
xref: MetaCyc:1.1.1.141-RXN
xref: RHEA:11879
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0016405
name: CoA-ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA." [GOC:ai]
subset: gosubset_prok
xref: Reactome:REACT_100240 "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate, Rattus norvegicus"
xref: Reactome:REACT_103951 "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate, Staphylococcus aureus N315"
xref: Reactome:REACT_107383 "salicylic acid + Coenzyme A + ATP => salicylate-CoA + AMP + pyrophosphate, Sus scrofa"
xref: Reactome:REACT_109160 "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate, Mus musculus"
xref: Reactome:REACT_109259 "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate, Bos taurus"
xref: Reactome:REACT_110151 "salicylic acid + Coenzyme A + ATP => salicylate-CoA + AMP + pyrophosphate, Canis familiaris"
xref: Reactome:REACT_112091 "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_112778 "salicylic acid + Coenzyme A + ATP => salicylate-CoA + AMP + pyrophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_113679 "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_6751 "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate, Homo sapiens"
xref: Reactome:REACT_6790 "salicylic acid + Coenzyme A + ATP => salicylate-CoA + AMP + pyrophosphate, Homo sapiens"
xref: Reactome:REACT_6972 "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate, Homo sapiens"
xref: Reactome:REACT_77001 "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate, Rattus norvegicus"
xref: Reactome:REACT_77592 "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate, Staphylococcus aureus N315"
xref: Reactome:REACT_84209 "salicylic acid + Coenzyme A + ATP => salicylate-CoA + AMP + pyrophosphate, Rattus norvegicus"
xref: Reactome:REACT_84800 "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate, Bos taurus"
xref: Reactome:REACT_89458 "salicylic acid + Coenzyme A + ATP => salicylate-CoA + AMP + pyrophosphate, Staphylococcus aureus N315"
xref: Reactome:REACT_89729 "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate, Mus musculus"
xref: Reactome:REACT_90499 "salicylic acid + Coenzyme A + ATP => salicylate-CoA + AMP + pyrophosphate, Mus musculus"
xref: Reactome:REACT_91132 "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate, Sus scrofa"
xref: Reactome:REACT_91475 "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate, Sus scrofa"
xref: Reactome:REACT_95104 "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate, Canis familiaris"
xref: Reactome:REACT_97606 "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate, Canis familiaris"
xref: Reactome:REACT_99435 "salicylic acid + Coenzyme A + ATP => salicylate-CoA + AMP + pyrophosphate, Bos taurus"
is_a: GO:0016877 ! ligase activity, forming carbon-sulfur bonds

[Term]
id: GO:0016406
name: carnitine O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an acyl group to an oxygen atom on the carnitine molecule." [GOC:ai]
subset: gosubset_prok
xref: EC:2.3.1.-
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0016407
name: acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an acetyl group to an acceptor molecule." [GOC:ai]
subset: goslim_metagenomics
subset: gosubset_prok
synonym: "acetylase activity" EXACT []
xref: EC:2.3.1.-
xref: Reactome:REACT_108863 "Acetylation of SL1, Bos taurus"
xref: Reactome:REACT_110154 "Acetylation of SL1, Mus musculus"
xref: Reactome:REACT_115357 "Acetylation of SL1, Xenopus tropicalis"
xref: Reactome:REACT_2113 "Acetylation of SL1, Homo sapiens"
xref: Reactome:REACT_77536 "Acetylation of SL1, Rattus norvegicus"
xref: Reactome:REACT_91894 "Acetylation of SL1, Taeniopygia guttata"
xref: Reactome:REACT_96328 "Acetylation of SL1, Canis familiaris"
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0016408
name: C-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an acyl group to a carbon atom on the acceptor molecule." [GOC:ai]
subset: gosubset_prok
xref: EC:2.3.1.-
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0016409
name: palmitoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai]
subset: gosubset_prok
xref: EC:2.3.1.-
xref: Reactome:REACT_108412 "palmitoylation of eNOS, Bos taurus"
xref: Reactome:REACT_12530 "palmitoylation of eNOS, Homo sapiens"
xref: Reactome:REACT_34066 "palmitoylation of eNOS, Sus scrofa"
xref: Reactome:REACT_78824 "palmitoylation of eNOS, Canis familiaris"
xref: Reactome:REACT_86763 "palmitoylation of eNOS, Xenopus tropicalis"
xref: Reactome:REACT_92113 "palmitoylation of eNOS, Mus musculus"
xref: Reactome:REACT_92691 "palmitoylation of eNOS, Rattus norvegicus"
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0016410
name: N-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]
subset: gosubset_prok
xref: EC:2.3.1.-
xref: Reactome:REACT_6927 "phenylacetyl-CoA + glutamine => phenylacetyl glutamine + Coenzyme A, Homo sapiens"
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0016411
name: acylglycerol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an acyl group to an oxygen atom on the acylglycerol molecule." [GOC:ai]
subset: gosubset_prok
xref: EC:2.3.1.-
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0016412
name: serine O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an acyl group to an oxygen atom on the serine molecule." [GOC:ai]
subset: gosubset_prok
xref: EC:2.3.1.-
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0016413
name: O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an acetyl group to an oxygen atom on the acceptor molecule." [GOC:ai]
subset: gosubset_prok
xref: EC:2.3.1.-
is_a: GO:0008374 ! O-acyltransferase activity
is_a: GO:0016407 ! acetyltransferase activity

[Term]
id: GO:0016414
name: O-octanoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an octanoyl group to an oxygen atom on the acceptor molecule." [GOC:ai]
xref: EC:2.3.1.-
is_a: GO:0008374 ! O-acyltransferase activity
is_a: GO:0016415 ! octanoyltransferase activity

[Term]
id: GO:0016415
name: octanoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an octanoyl (CH3-[CH2]6-CO-) group to an acceptor molecule." [GOC:ai]
xref: EC:2.3.1.-
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0016416
name: O-palmitoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a palmitoyl group to an oxygen atom on the acceptor molecule." [GOC:ai]
xref: EC:2.3.1.-
is_a: GO:0008374 ! O-acyltransferase activity
is_a: GO:0016409 ! palmitoyltransferase activity

[Term]
id: GO:0016417
name: S-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an acyl group to a sulfur atom on the acceptor molecule." [GOC:ai]
subset: gosubset_prok
xref: EC:2.3.1.-
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0016418
name: S-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an acetyl group to a sulfur atom on the acceptor molecule." [GOC:ai]
subset: gosubset_prok
xref: EC:2.3.1.-
is_a: GO:0016407 ! acetyltransferase activity
is_a: GO:0016417 ! S-acyltransferase activity

[Term]
id: GO:0016419
name: S-malonyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a malonyl group to a sulfur atom on the acceptor molecule." [GOC:ai]
subset: gosubset_prok
xref: EC:2.3.1.-
is_a: GO:0016417 ! S-acyltransferase activity
is_a: GO:0016420 ! malonyltransferase activity

[Term]
id: GO:0016420
name: malonyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a malonyl (HOOC-CH2-CO-) group to an acceptor molecule." [GOC:ai]
subset: gosubset_prok
xref: EC:2.3.1.-
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0016421
name: CoA carboxylase activity
namespace: molecular_function
def: "Catalysis of the joining of a carboxyl group to a molecule that is attached to CoA, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:mah]
subset: gosubset_prok
xref: EC:6.4.1.-
is_a: GO:0016885 ! ligase activity, forming carbon-carbon bonds

[Term]
id: GO:0016422
name: mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + m(7)G(5')pppAm = S-adenosyl-L-homocysteine + m(7)G(5')pppm(6)Am." [EC:2.1.1.62]
synonym: "messenger ribonucleate 2'-O-methyladenosine NG-methyltransferase activity" EXACT [EC:2.1.1.62]
synonym: "S-adenosyl-L-methionine:mRNA (2'-O-methyladenosine-6-N-)-methyltransferase activity" EXACT [EC:2.1.1.62]
synonym: "S-adenosyl-L-methionine:mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity" EXACT [EC:2.1.1.62]
xref: EC:2.1.1.62
xref: MetaCyc:2.1.1.62-RXN
is_a: GO:0008174 ! mRNA methyltransferase activity

[Term]
id: GO:0016423
name: tRNA (guanine) methyltransferase activity
namespace: molecular_function
alt_id: GO:0016424
def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methylguanine." [EC:2.1.1.-]
subset: gosubset_prok
synonym: "tRNA (guanosine) methyltransferase activity" EXACT []
xref: EC:2.1.1.-
is_a: GO:0008175 ! tRNA methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0016426
name: tRNA (adenine) methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methyladenine." [EC:2.1.1.-]
subset: gosubset_prok
xref: EC:2.1.1.-
is_a: GO:0008175 ! tRNA methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0016427
name: tRNA (cytosine) methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methylcytosine." [EC:2.1.1.-]
xref: EC:2.1.1.-
is_a: GO:0008175 ! tRNA methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0016428
name: tRNA (cytosine-5-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 5-methylcytosine." [EC:2.1.1.29]
synonym: "S-adenosyl-L-methionine:tRNA (cytosine-5-)-methyltransferase activity" EXACT [EC:2.1.1.29]
synonym: "transfer ribonucleate cytosine 5-methyltransferase activity" EXACT [EC:2.1.1.29]
synonym: "transfer RNA cytosine 5-methyltransferase activity" EXACT [EC:2.1.1.29]
xref: EC:2.1.1.-
is_a: GO:0016427 ! tRNA (cytosine) methyltransferase activity

[Term]
id: GO:0016429
name: tRNA (adenine-N1-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methyladenine." [EC:2.1.1.36]
subset: gosubset_prok
synonym: "1-methyladenine transfer RNA methyltransferase activity" EXACT [EC:2.1.1.36]
synonym: "adenine-1-methylase activity" EXACT [EC:2.1.1.36]
synonym: "S-adenosyl-L-methionine:tRNA (adenine-1-N-)-methyltransferase activity" EXACT [EC:2.1.1.36]
synonym: "S-adenosyl-L-methionine:tRNA (adenine-N1-)-methyltransferase activity" EXACT [EC:2.1.1.36]
synonym: "transfer ribonucleate adenine 1-methyltransferase activity" EXACT [EC:2.1.1.36]
synonym: "transfer RNA (adenine-1) methyltransferase activity" EXACT [EC:2.1.1.36]
xref: EC:2.1.1.-
is_a: GO:0016426 ! tRNA (adenine) methyltransferase activity

[Term]
id: GO:0016430
name: tRNA (adenine-N6-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N6-methyladenine." [EC:2.1.1.55]
synonym: "S-adenosyl-L-methionine:tRNA (adenine-6-N-)-methyltransferase activity" EXACT [EC:2.1.1.55]
synonym: "S-adenosyl-L-methionine:tRNA (adenine-N6-)-methyltransferase activity" EXACT [EC:2.1.1.55]
xref: EC:2.1.1.55
xref: MetaCyc:TRNA-ADENINE-N6--METHYLTRANSFERASE-RXN
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0016426 ! tRNA (adenine) methyltransferase activity

[Term]
id: GO:0016432
name: tRNA-uridine aminocarboxypropyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA uridine = 5'-methylthioadenosine + tRNA 3-(3-amino-3-carboxypropyl)-uridine." [EC:2.5.1.25]
synonym: "S-adenosyl-L-methionine:tRNA-uridine 3-(3-amino-3-carboxypropyl)transferase activity" EXACT [EC:2.5.1.25]
xref: EC:2.5.1.25
xref: MetaCyc:2.5.1.25-RXN
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0016433
name: rRNA (adenine) methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methyladenine." [EC:2.1.1.-]
subset: gosubset_prok
xref: EC:2.1.1.-
is_a: GO:0008649 ! rRNA methyltransferase activity

[Term]
id: GO:0016434
name: rRNA (cytosine) methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methylcytosine." [EC:2.1.1.-]
subset: gosubset_prok
xref: EC:2.1.1.-
is_a: GO:0008649 ! rRNA methyltransferase activity

[Term]
id: GO:0016435
name: rRNA (guanine) methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methylguanine." [EC:2.1.1.-]
subset: gosubset_prok
xref: EC:2.1.1.-
is_a: GO:0008649 ! rRNA methyltransferase activity

[Term]
id: GO:0016436
name: rRNA (uridine) methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methyluridine." [EC:2.1.1.-]
subset: gosubset_prok
xref: EC:2.1.1.-
is_a: GO:0008649 ! rRNA methyltransferase activity

[Term]
id: GO:0016437
name: tRNA cytidylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CTP + tRNA(n) = diphosphate + tRNA(n+1)." [EC:2.7.7.21]
comment: This term represents a deleted EC activity and is scheduled for obsoletion.
subset: mf_needs_review
synonym: "-C-C-A pyrophosphorylase" BROAD [EC:2.7.7.21]
synonym: "ATP (CTP):tRNA nucleotidyltransferase" BROAD [EC:2.7.7.21]
synonym: "ATP(CTP)-tRNA nucleotidyltransferase" BROAD [EC:2.7.7.21]
synonym: "ATP(CTP):tRNA nucleotidyltransferase activity" BROAD [EC:2.7.7.21]
synonym: "CTP(ATP):tRNA nucleotidyltransferase" BROAD [EC:2.7.7.21]
synonym: "CTP:tRNA cytidylyltransferase activity" BROAD []
synonym: "ribonucleic cytidylic cytidylic adenylic pyrophosphorylase" BROAD [EC:2.7.7.21]
synonym: "ribonucleic cytidylyltransferase" BROAD [EC:2.7.7.21]
synonym: "transfer ribonucleate adenylyltransferase" BROAD [EC:2.7.7.21]
synonym: "transfer ribonucleate cytidylyltransferase" BROAD [EC:2.7.7.21]
synonym: "transfer ribonucleate nucleotidyltransferase" BROAD [EC:2.7.7.21]
synonym: "transfer ribonucleic acid nucleotidyl transferase" BROAD [EC:2.7.7.21]
synonym: "transfer ribonucleic adenylyl (cytidylyl) transferase" BROAD [EC:2.7.7.21]
synonym: "transfer ribonucleic-terminal trinucleotide nucleotidyltransferase" BROAD [EC:2.7.7.21]
synonym: "transfer RNA adenylyltransferase" BROAD [EC:2.7.7.21]
synonym: "transfer-RNA nucleotidyltransferase" BROAD [EC:2.7.7.21]
synonym: "tRNA adenylyl(cytidylyl)transferase" BROAD [EC:2.7.7.21]
synonym: "tRNA CCA-diphosphorylase activity" RELATED [EC:2.7.7.21]
synonym: "tRNA CCA-pyrophosphorylase activity" RELATED [EC:2.7.7.21]
xref: EC:2.7.7.21
xref: MetaCyc:TRNA-CYTIDYLYLTRANSFERASE-RXN
is_a: GO:0070567 ! cytidylyltransferase activity

[Term]
id: GO:0016438
name: tRNA-queuosine beta-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-mannose + tRNA(Asp)-queuosine = GDP + tRNA(Asp)-O-5''-beta-D-mannosylqueuosine." [EC:2.4.1.110]
synonym: "GDP-mannose:tRNAAsp-queuosine O-5''-beta-D-mannosyltransferase activity" EXACT [EC:2.4.1.110]
xref: EC:2.4.1.110
xref: MetaCyc:2.4.1.110-RXN
is_a: GO:0000030 ! mannosyltransferase activity

[Term]
id: GO:0016441
name: posttranscriptional gene silencing
namespace: biological_process
def: "The inactivation of gene expression by a posttranscriptional mechanism." [GOC:mah, PMID:15020054]
synonym: "cosuppression" RELATED []
synonym: "post-transcriptional gene silencing" EXACT [GOC:vw]
synonym: "PTGS" EXACT []
synonym: "quelling" EXACT []
xref: Wikipedia:Post_transcriptional_gene_silencing
is_a: GO:0010608 ! posttranscriptional regulation of gene expression
is_a: GO:0016458 ! gene silencing
is_a: GO:0040029 ! regulation of gene expression, epigenetic

[Term]
id: GO:0016442
name: RISC complex
namespace: cellular_component
def: "A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation." [PMID:10749213, PMID:15145345]
synonym: "RNA-induced silencing complex" EXACT []
xref: Wikipedia:RNA-induced_silencing_complex
is_a: GO:0031332 ! RNAi effector complex

[Term]
id: GO:0016443
name: bidentate ribonuclease III activity
namespace: molecular_function
def: "Catalysis of the digestion of double-stranded RNAs into 20 to 30-nucleotide products. These products typically associate to the RNA-induced silencing complex and serve as guide RNAs for posttranslational RNA interference." [PMID:15242644]
synonym: "bidentate RNase III activity" EXACT []
xref: EC:3.1.26.-
is_a: GO:0004525 ! ribonuclease III activity

[Term]
id: GO:0016444
name: somatic cell DNA recombination
namespace: biological_process
def: "Recombination occurring within or between DNA molecules in somatic cells." [GOC:ma]
is_a: GO:0006310 ! DNA recombination

[Term]
id: GO:0016445
name: somatic diversification of immunoglobulins
namespace: biological_process
def: "The somatic process that results in the generation of sequence diversity of immunoglobulins." [GOC:add, GOC:ma, ISBN:0781735149]
synonym: "somatic diversification of antibodies" EXACT []
is_a: GO:0002200 ! somatic diversification of immune receptors
relationship: part_of GO:0002377 ! immunoglobulin production

[Term]
id: GO:0016446
name: somatic hypermutation of immunoglobulin genes
namespace: biological_process
def: "Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins." [GOC:add, ISBN:0781735149, PMID:11205330, PMID:11205333, PMID:14975236, PMID:7813007]
synonym: "somatic hypermutation of antibody genes" EXACT []
is_a: GO:0002566 ! somatic diversification of immune receptors via somatic mutation
is_a: GO:0016445 ! somatic diversification of immunoglobulins

[Term]
id: GO:0016447
name: somatic recombination of immunoglobulin gene segments
namespace: biological_process
def: "The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, as known as immunoglobulin gene segments, within a single locus." [GOC:add, ISBN:0781735149]
synonym: "somatic recombination of antibody gene segments" EXACT []
is_a: GO:0002562 ! somatic diversification of immune receptors via germline recombination within a single locus
is_a: GO:0016445 ! somatic diversification of immunoglobulins

[Term]
id: GO:0016453
name: C-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an acetyl group to a carbon atom on the acceptor molecule." [GOC:ai]
subset: gosubset_prok
is_a: GO:0016407 ! acetyltransferase activity
is_a: GO:0016408 ! C-acyltransferase activity

[Term]
id: GO:0016454
name: C-palmitoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a palmitoyl group to a carbon atom on the acceptor molecule." [GOC:ai]
xref: EC:2.3.1.-
is_a: GO:0016408 ! C-acyltransferase activity
is_a: GO:0016409 ! palmitoyltransferase activity

[Term]
id: GO:0016456
name: X chromosome located dosage compensation complex, transcription activating
namespace: cellular_component
def: "An RNA-protein complex localized to the X chromosome of males where it is required for the hyper-transcriptional activation of the X chromosome. An example of this is found in Drosophila melanogaster." [GOC:ma, GOC:mtg_sensu]
synonym: "dosage compensation complex" BROAD []
is_a: GO:0030529 ! intracellular ribonucleoprotein complex
is_a: GO:0046536 ! dosage compensation complex
relationship: part_of GO:0000805 ! X chromosome

[Term]
id: GO:0016457
name: dosage compensation complex assembly involved in dosage compensation by hyperactivation of X chromosome
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins on DNA to form the complex that mediates dosage compensation on the X chromosome of the heterogametic sex, ultimately resulting in a two-fold increase in transcription from this chromosome. An example of this is found in Drosophila melanogaster." [GOC:jl]
synonym: "dosage compensation complex assembly during dosage compensation by hyperactivation of X chromosome" RELATED [GOC:dph, GOC:tb]
is_a: GO:0042714 ! dosage compensation complex assembly
is_a: GO:0065004 ! protein-DNA complex assembly
intersection_of: GO:0042714 ! dosage compensation complex assembly
intersection_of: part_of GO:0009047 ! dosage compensation by hyperactivation of X chromosome
relationship: part_of GO:0009047 ! dosage compensation by hyperactivation of X chromosome

[Term]
id: GO:0016458
name: gene silencing
namespace: biological_process
def: "Any process carried out at the cellular level that results in either long-term transcriptional repression via action on chromatin structure or RNA mediated, post-transcriptional repression of gene expression." [GOC:dos, GOC:dph, GOC:jid, GOC:tb]
comment: This is a rather broad grouping term.  While it was originally defined for long-term, heritable, epigenetic effects, short term effects on expression mediated by RNA are also frequently referred to as gene silencing, and are grouped under this class.
subset: goslim_pir
synonym: "long-term maintenance of gene inactivation" NARROW []
xref: Wikipedia:Gene_silencing
is_a: GO:0010629 ! negative regulation of gene expression
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0016459
name: myosin complex
namespace: cellular_component
def: "A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764]
is_a: GO:0043234 ! protein complex
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0015629 ! actin cytoskeleton

[Term]
id: GO:0016460
name: myosin II complex
namespace: cellular_component
def: "A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764]
synonym: "conventional myosin" RELATED []
is_a: GO:0016459 ! myosin complex

[Term]
id: GO:0016461
name: unconventional myosin complex
namespace: cellular_component
alt_id: GO:0005860
def: "A portmanteau term for myosins other than myosin II." [GOC:ma]
comment: Note that this term is retained because it is widely used by biologists.
synonym: "non-muscle myosin" RELATED []
is_a: GO:0016459 ! myosin complex

[Term]
id: GO:0016462
name: pyrophosphatase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a pyrophosphate bond between two phosphate groups, leaving one phosphate on each of the two fragments." [EC:3.6.1.-, GOC:curators]
subset: gosubset_prok
xref: EC:3.6.1.-
is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

[Term]
id: GO:0016463
name: zinc-exporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Zn2+(in) -> ADP + phosphate + Zn2+(out)." [EC:3.6.3.5]
subset: gosubset_prok
synonym: "AtHMA4" RELATED [EC:3.6.3.5]
synonym: "ATP phosphohydrolase (Zn2+-exporting)" EXACT [EC:3.6.3.5]
synonym: "P(1B)-type ATPase activity" NARROW [EC:3.6.3.5]
synonym: "P1B-type ATPase activity" EXACT [EC:3.6.3.5]
synonym: "zinc exporting ATPase activity" EXACT []
synonym: "zinc-translocating P-type ATPase activity" BROAD [EC:3.6.3.5]
synonym: "Zn(2+)-exporting ATPase activity" EXACT [EC:3.6.3.5]
synonym: "Zn(II)-translocating P-type ATPase activity" EXACT [EC:3.6.3.5]
synonym: "Zn2+-exporting ATPase activity" EXACT [EC:3.6.3.5]
xref: EC:3.6.3.5
xref: MetaCyc:3.6.3.5-RXN
xref: RHEA:20624
is_a: GO:0005385 ! zinc ion transmembrane transporter activity
is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
is_a: GO:0019829 ! cation-transporting ATPase activity

[Term]
id: GO:0016464
name: chloroplast protein-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of proteins into the chloroplast stroma." [EC:3.6.3.52]
synonym: "ATP phosphohydrolase (chloroplast protein-importing)" EXACT [EC:3.6.3.52]
synonym: "chloroplast protein ABC transporter" NARROW []
xref: EC:3.6.3.52
xref: MetaCyc:3.6.3.52-RXN
is_a: GO:0015462 ! protein-transmembrane transporting ATPase activity

[Term]
id: GO:0016465
name: chaperonin ATPase complex
namespace: cellular_component
def: "Multisubunit protein complex with 2x7 (Type I, in most cells) or 2x8 (Type II, in Archaea) ATP-binding sites involved in maintaining an unfolded polypeptide structure before folding or to entry into mitochondria and chloroplasts." [EC:3.6.4.9]
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0016466
name: obsolete hydrogen-translocating A-type ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out). Found in archae." [TC:3.A.2.3.1]
comment: This term was made obsolete because it represents a gene product.
synonym: "hydrogen-translocating A-type ATPase activity" EXACT []
synonym: "proton-translocating A-type ATPase activity" EXACT []
is_obsolete: true
replaced_by: GO:0046961

[Term]
id: GO:0016467
name: obsolete hydrogen-translocating F-type ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out). Found in eukaryotic mitochondria and chloroplasts and in bacteria." [TC:3.A.2.1.1, TC:3.A.2.1.3]
comment: This term was made obsolete because it represents a gene product.
synonym: "ATP synthase" BROAD []
synonym: "F1-ATPase activity" EXACT []
synonym: "hydrogen-translocating F-type ATPase activity" EXACT []
synonym: "proton-translocating F-type ATPase activity" EXACT []
is_obsolete: true
consider: GO:0046933
consider: GO:0046961

[Term]
id: GO:0016468
name: obsolete sodium-translocating F-type ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out). Found in eukaryotic mitochondria and chloroplasts and in bacteria." [TC:3.A.2.1.2]
comment: This term was made obsolete because it represents a gene product.
synonym: "ATP synthase" BROAD []
synonym: "sodium-translocating F-type ATPase activity" EXACT []
is_obsolete: true
consider: GO:0046932
consider: GO:0046962

[Term]
id: GO:0016469
name: proton-transporting two-sector ATPase complex
namespace: cellular_component
def: "A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible." [GOC:mah, ISBN:0716743663, PMID:16691483]
subset: goslim_metagenomics
subset: goslim_pir
subset: gosubset_prok
synonym: "hydrogen-transporting two-sector ATPase complex" EXACT []
synonym: "vacuolar hydrogen-transporting ATPase" RELATED []
is_a: GO:0098796 ! membrane protein complex

[Term]
id: GO:0016471
name: vacuolar proton-transporting V-type ATPase complex
namespace: cellular_component
def: "A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen." [GOC:mah, ISBN:0716743663, PMID:16449553]
comment: See also the cellular component terms 'vacuolar proton-transporting V-type ATPase, V1 domain ; GO:0000221' and 'vacuolar proton-transporting V-type ATPase, V0 domain ; GO:0000220' and the molecular function term 'hydrogen ion transporting ATPase activity, rotational mechanism ; GO:0046961'.
subset: gosubset_prok
synonym: "vacuolar hydrogen-translocating V-type ATPase complex" EXACT []
is_a: GO:0033176 ! proton-transporting V-type ATPase complex
is_a: GO:0044437 ! vacuolar part
intersection_of: GO:0033176 ! proton-transporting V-type ATPase complex
intersection_of: part_of GO:0005773 ! vacuole
relationship: part_of GO:0005773 ! vacuole
relationship: part_of GO:0005774 ! vacuolar membrane

[Term]
id: GO:0016472
name: sodium ion-transporting two-sector ATPase complex
namespace: cellular_component
def: "A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of sodium ions across a membrane. The complex comprises a membrane sector (F0 or V0) that carries out ion transport and a cytoplasmic compartment sector (F1 or V1) that catalyzes ATP synthesis or hydrolysis." [GOC:mah, PMID:14656431]
subset: goslim_pir
synonym: "sodium-transporting two-sector ATPase complex" EXACT []
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0016021 ! integral component of membrane

[Term]
id: GO:0016473
name: sodium ion-transporting F-type ATPase complex
namespace: cellular_component
def: "A sodium ion-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism." [GOC:mah, PMID:14656431]
synonym: "sodium-translocating F-type ATPase complex" EXACT []
is_a: GO:0016472 ! sodium ion-transporting two-sector ATPase complex

[Term]
id: GO:0016474
name: sodium ion-transporting V-type ATPase complex
namespace: cellular_component
def: "A sodium ion-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of sodium ions across a concentration gradient. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis." [GOC:mah, PMID:15802565]
synonym: "sodium-translocating V-type ATPase complex" EXACT []
is_a: GO:0016472 ! sodium ion-transporting two-sector ATPase complex

[Term]
id: GO:0016475
name: detection of nuclear:cytoplasmic ratio
namespace: biological_process
def: "The process in which the size of the nucleus with respect to its cytoplasm is sensed by a cell." [GOC:jl]
synonym: "interpretation of nuclear:cytoplasmic ratio" EXACT []
synonym: "sensing of nuclear:cytoplasmic ratio" EXACT []
is_a: GO:0009726 ! detection of endogenous stimulus
relationship: part_of GO:0016049 ! cell growth

[Term]
id: GO:0016476
name: regulation of embryonic cell shape
namespace: biological_process
def: "Any process that modulates the surface configuration of an embryonic cell." [GOC:dph, GOC:tb]
synonym: "shape changes of embryonic cells" RELATED [GOC:dph, GOC:tb]
is_a: GO:0008360 ! regulation of cell shape
is_a: GO:0045995 ! regulation of embryonic development

[Term]
id: GO:0016477
name: cell migration
namespace: biological_process
def: "The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, http://en.wikipedia.org/wiki/Cell_migration]
xref: Wikipedia:Cell_migration
is_a: GO:0048870 ! cell motility

[Term]
id: GO:0016479
name: negative regulation of transcription from RNA polymerase I promoter
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase I promoter." [GOC:go_curators]
synonym: "down regulation of transcription from RNA polymerase I promoter" EXACT []
synonym: "down-regulation of transcription from RNA polymerase I promoter" EXACT []
synonym: "downregulation of transcription from RNA polymerase I promoter" EXACT []
synonym: "inhibition of transcription from RNA polymerase I promoter" NARROW []
synonym: "negative regulation of transcription from Pol I promoter" EXACT []
is_a: GO:0006356 ! regulation of transcription from RNA polymerase I promoter
is_a: GO:0045892 ! negative regulation of transcription, DNA-templated
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006360 ! transcription from RNA polymerase I promoter
relationship: negatively_regulates GO:0006360 ! transcription from RNA polymerase I promoter

[Term]
id: GO:0016480
name: negative regulation of transcription from RNA polymerase III promoter
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase III promoter." [GOC:go_curators]
synonym: "down regulation of transcription from RNA polymerase III promoter" EXACT []
synonym: "down-regulation of transcription from RNA polymerase III promoter" EXACT []
synonym: "downregulation of transcription from RNA polymerase III promoter" EXACT []
synonym: "inhibition of transcription from RNA polymerase III promoter" NARROW []
synonym: "negative regulation of transcription from Pol III promoter" EXACT []
is_a: GO:0006359 ! regulation of transcription from RNA polymerase III promoter
is_a: GO:0045892 ! negative regulation of transcription, DNA-templated
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006383 ! transcription from RNA polymerase III promoter
relationship: negatively_regulates GO:0006383 ! transcription from RNA polymerase III promoter

[Term]
id: GO:0016482
name: cytosolic transport
namespace: biological_process
def: "The directed movement of substances or organelles within the cytosol." [GOC:ai]
is_a: GO:0046907 ! intracellular transport
intersection_of: GO:0006810 ! transport
intersection_of: occurs_in GO:0005829 ! cytosol
relationship: occurs_in GO:0005829 ! cytosol

[Term]
id: GO:0016483
name: tryptophan hydroxylase activator activity
namespace: molecular_function
def: "Increases the activity of the enzyme tryptophase hydroxylase." [GOC:ai]
is_a: GO:0008047 ! enzyme activator activity
relationship: positively_regulates GO:0004510 ! tryptophan 5-monooxygenase activity

[Term]
id: GO:0016484
name: obsolete proprotein convertase 2 activator activity
namespace: molecular_function
def: "OBSOLETE. Required for the maturation and activation of proprotein convertase 2." [GOC:ma, PMID:10749852]
comment: This term was made obsolete because it represents a regulator of an obsolete molecular function.
synonym: "proprotein convertase 2 activator activity" EXACT []
is_obsolete: true
consider: GO:0016504

[Term]
id: GO:0016485
name: protein processing
namespace: biological_process
alt_id: GO:0051605
def: "Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]
subset: goslim_chembl
subset: gosubset_prok
synonym: "peptidolysis during protein maturation" RELATED [GOC:mah]
synonym: "protein maturation by peptide bond cleavage" EXACT [GOC:bf]
synonym: "protein maturation by peptide bond hydrolysis" EXACT [GOC:mah]
synonym: "protein maturation by proteolysis" RELATED [GOC:mah]
is_a: GO:0006508 ! proteolysis
is_a: GO:0051604 ! protein maturation

[Term]
id: GO:0016486
name: peptide hormone processing
namespace: biological_process
def: "The generation of a mature peptide hormone by posttranslational processing of a prohormone." [GOC:mah]
xref: Reactome:REACT_100567 "Peptide hormone biosynthesis, Canis familiaris"
xref: Reactome:REACT_100961 "Peptide hormone biosynthesis, Bos taurus"
xref: Reactome:REACT_109010 "Peptide hormone biosynthesis, Gallus gallus"
xref: Reactome:REACT_109092 "Peptide hormone biosynthesis, Xenopus tropicalis"
xref: Reactome:REACT_15452 "Peptide hormone biosynthesis, Homo sapiens"
xref: Reactome:REACT_30665 "Peptide hormone biosynthesis, Sus scrofa"
xref: Reactome:REACT_34278 "Peptide hormone biosynthesis, Taeniopygia guttata"
xref: Reactome:REACT_91994 "Peptide hormone biosynthesis, Mus musculus"
xref: Reactome:REACT_93420 "Peptide hormone biosynthesis, Rattus norvegicus"
xref: Reactome:REACT_96896 "Peptide hormone biosynthesis, Danio rerio"
is_a: GO:0006518 ! peptide metabolic process
is_a: GO:0016485 ! protein processing
is_a: GO:0042445 ! hormone metabolic process

[Term]
id: GO:0016487
name: farnesol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the sesquiterpenoid alcohol farnesol, 3,7,11-trimethyl-2,6,10,dodecatrien-1-ol." [GOC:go_curators]
subset: gosubset_prok
synonym: "farnesol metabolism" EXACT []
is_a: GO:0006714 ! sesquiterpenoid metabolic process
is_a: GO:0016093 ! polyprenol metabolic process
is_a: GO:0034308 ! primary alcohol metabolic process

[Term]
id: GO:0016488
name: farnesol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the sesquiterpenoid alcohol farnesol, 3,7,11-trimethyl-2,6,10,dodecatrien-1-ol." [GOC:go_curators]
subset: gosubset_prok
synonym: "farnesol breakdown" EXACT []
synonym: "farnesol catabolism" EXACT []
synonym: "farnesol degradation" EXACT []
is_a: GO:0016095 ! polyprenol catabolic process
is_a: GO:0016107 ! sesquiterpenoid catabolic process
is_a: GO:0016487 ! farnesol metabolic process
is_a: GO:0034310 ! primary alcohol catabolic process

[Term]
id: GO:0016490
name: structural constituent of peritrophic membrane
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of the peritrophic membrane, a tubular sheath of cuticle that shields the epithelial cells of the midgut from the gut contents. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
synonym: "structural constituent of peritrophic matrix" RELATED []
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0016491
name: oxidoreductase activity
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
comment: Note that enzymes of class EC:1.97.-.- should also be annotated to this term.
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on other substrates" NARROW []
synonym: "redox activity" EXACT []
xref: EC:1
xref: Reactome:REACT_102858 "Diiodinated tyrosine can be deiodinated, Mus musculus"
xref: Reactome:REACT_102973 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Canis familiaris"
xref: Reactome:REACT_103874 "Monoiodinated tyrosine can be deiodinated, Canis familiaris"
xref: Reactome:REACT_104604 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Danio rerio"
xref: Reactome:REACT_105062 "Monoiodinated tyrosine can be deiodinated, Danio rerio"
xref: Reactome:REACT_105121 "Monoiodinated tyrosine can be deiodinated, Caenorhabditis elegans"
xref: Reactome:REACT_106088 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Rattus norvegicus"
xref: Reactome:REACT_106276 "Monoiodinated tyrosine can be deiodinated, Rattus norvegicus"
xref: Reactome:REACT_107002 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Sus scrofa"
xref: Reactome:REACT_107467 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Rattus norvegicus"
xref: Reactome:REACT_108745 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Taeniopygia guttata"
xref: Reactome:REACT_109500 "Monoiodinated tyrosine can be deiodinated, Bos taurus"
xref: Reactome:REACT_110582 "Diiodinated tyrosine can be deiodinated, Rattus norvegicus"
xref: Reactome:REACT_115316 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Drosophila melanogaster"
xref: Reactome:REACT_15389 "Monoiodinated tyrosine can be deiodinated, Homo sapiens"
xref: Reactome:REACT_15410 "Diiodinated tyrosine can be deiodinated, Homo sapiens"
xref: Reactome:REACT_17006 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Homo sapiens"
xref: Reactome:REACT_17042 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Homo sapiens"
xref: Reactome:REACT_29212 "Diiodinated tyrosine can be deiodinated, Canis familiaris"
xref: Reactome:REACT_30160 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Mus musculus"
xref: Reactome:REACT_31762 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Gallus gallus"
xref: Reactome:REACT_32960 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Bos taurus"
xref: Reactome:REACT_34705 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Mus musculus"
xref: Reactome:REACT_44470 "Monoiodinated tyrosine can be deiodinated, Mus musculus"
xref: Reactome:REACT_78923 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Taeniopygia guttata"
xref: Reactome:REACT_84842 "Diiodinated tyrosine can be deiodinated, Gallus gallus"
xref: Reactome:REACT_86178 "Monoiodinated tyrosine can be deiodinated, Xenopus tropicalis"
xref: Reactome:REACT_88304 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Bos taurus"
xref: Reactome:REACT_89057 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Gallus gallus"
xref: Reactome:REACT_90394 "Diiodinated tyrosine can be deiodinated, Xenopus tropicalis"
xref: Reactome:REACT_91638 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Arabidopsis thaliana"
xref: Reactome:REACT_91952 "Monoiodinated tyrosine can be deiodinated, Gallus gallus"
xref: Reactome:REACT_92075 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Xenopus tropicalis"
xref: Reactome:REACT_92434 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Canis familiaris"
xref: Reactome:REACT_93539 "Diiodinated tyrosine can be deiodinated, Drosophila melanogaster"
xref: Reactome:REACT_93974 "Diiodinated tyrosine can be deiodinated, Taeniopygia guttata"
xref: Reactome:REACT_95169 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Danio rerio"
xref: Reactome:REACT_95558 "Monoiodinated tyrosine can be deiodinated, Sus scrofa"
xref: Reactome:REACT_95573 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Caenorhabditis elegans"
xref: Reactome:REACT_97234 "Diiodinated tyrosine can be deiodinated, Caenorhabditis elegans"
xref: Reactome:REACT_97568 "Diiodinated tyrosine can be deiodinated, Sus scrofa"
xref: Reactome:REACT_97851 "Diiodinated tyrosine can be deiodinated, Bos taurus"
xref: Reactome:REACT_98022 "Monoiodinated tyrosine can be deiodinated, Drosophila melanogaster"
xref: Reactome:REACT_99085 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Oryza sativa"
xref: Reactome:REACT_99794 "Diiodinated tyrosine can be deiodinated, Danio rerio"
xref: Reactome:REACT_99989 "Monoiodinated tyrosine can be deiodinated, Taeniopygia guttata"
is_a: GO:0003824 ! catalytic activity
relationship: part_of GO:0055114 ! oxidation-reduction process

[Term]
id: GO:0016492
name: G-protein coupled neurotensin receptor activity
namespace: molecular_function
def: "Combining with the tridecapeptide neurotensin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state." [PMID:10390649]
synonym: "G protein coupled neurotensin receptor activity" EXACT []
synonym: "G-protein-coupled neurotensin receptor activity" EXACT []
synonym: "neurotensin receptor activity, G protein coupled" EXACT []
synonym: "neurotensin receptor activity, G-protein coupled" EXACT [GOC:bf]
is_a: GO:0008188 ! neuropeptide receptor activity

[Term]
id: GO:0016493
name: C-C chemokine receptor activity
namespace: molecular_function
def: "Combining with a C-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif." [GOC:signaling, PMID:8662823]
is_a: GO:0004950 ! chemokine receptor activity
relationship: has_part GO:0019957 ! C-C chemokine binding

[Term]
id: GO:0016494
name: C-X-C chemokine receptor activity
namespace: molecular_function
def: "Combining with a C-X-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A C-X-C chemokine has a single amino acid between the first two cysteines of the characteristic four cysteine motif." [GOC:signaling, PMID:8662823]
is_a: GO:0004950 ! chemokine receptor activity
relationship: has_part GO:0019958 ! C-X-C chemokine binding

[Term]
id: GO:0016495
name: C-X3-C chemokine receptor activity
namespace: molecular_function
def: "Combining with a C-X3-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A C-X3-C chemokine has three amino acids between the first two cysteines of the characteristic four-cysteine motif." [GOC:dph, GOC:signaling]
is_a: GO:0004950 ! chemokine receptor activity
relationship: has_part GO:0019960 ! C-X3-C chemokine binding

[Term]
id: GO:0016496
name: substance P receptor activity
namespace: molecular_function
def: "Combining with substance P, the peptide Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met, to initiate a change in cell activity." [GOC:mah, ISBN:0198506732]
is_a: GO:0004995 ! tachykinin receptor activity

[Term]
id: GO:0016497
name: substance K receptor activity
namespace: molecular_function
def: "Combining with substance K, the peptide His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met, to initiate a change in cell activity." [GOC:mah, ISBN:0198506732]
synonym: "neurokinin A receptor activity" EXACT []
synonym: "neuromedin L receptor activity" EXACT []
is_a: GO:0004995 ! tachykinin receptor activity

[Term]
id: GO:0016498
name: neuromedin K receptor activity
namespace: molecular_function
def: "Combining with neuromedin K, the peptide Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met to initiate a change in cell activity." [GOC:mah, ISBN:0198506732]
synonym: "neurokinin B receptor activity" EXACT []
is_a: GO:0004995 ! tachykinin receptor activity

[Term]
id: GO:0016499
name: orexin receptor activity
namespace: molecular_function
def: "Combining with orexin to initiate a change in cell activity." [GOC:ai]
is_a: GO:0008528 ! G-protein coupled peptide receptor activity

[Term]
id: GO:0016500
name: protein-hormone receptor activity
namespace: molecular_function
def: "Combining with a protein hormone to initiate a change in cell activity." [GOC:mah]
is_a: GO:0004930 ! G-protein coupled receptor activity

[Term]
id: GO:0016501
name: prostacyclin receptor activity
namespace: molecular_function
alt_id: GO:0004959
def: "Combining with prostacyclin (PGI(2)) to initiate a change in cell activity." [ISBN:0198506732]
synonym: "PGI receptor activity" RELATED []
synonym: "PGI(2) receptor activity" EXACT []
synonym: "prostaglandin I receptor activity" EXACT []
is_a: GO:0004955 ! prostaglandin receptor activity

[Term]
id: GO:0016502
name: nucleotide receptor activity
namespace: molecular_function
def: "Combining with a nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule." [GOC:signaling, ISBN:0198506732]
is_a: GO:0004888 ! transmembrane signaling receptor activity
relationship: has_part GO:0000166 ! nucleotide binding

[Term]
id: GO:0016503
name: pheromone receptor activity
namespace: molecular_function
def: "Combining with a pheromone to initiate a change in cell activity. A pheromone is a substance used in olfactory communication between organisms of the same species eliciting a change in sexual or social behavior." [CHEBI:26013, GOC:hjd, ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0004930 ! G-protein coupled receptor activity
relationship: has_part GO:0005550 ! pheromone binding

[Term]
id: GO:0016504
name: peptidase activator activity
namespace: molecular_function
def: "Binds to and increases the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:ai]
subset: gosubset_prok
synonym: "protease activator activity" NARROW [GOC:mah]
xref: Reactome:REACT_6229 "NA activation of TGF-beta, Homo sapiens"
is_a: GO:0008047 ! enzyme activator activity
is_a: GO:0061134 ! peptidase regulator activity
relationship: part_of GO:0010952 ! positive regulation of peptidase activity
relationship: positively_regulates GO:0008233 ! peptidase activity

[Term]
id: GO:0016505
name: peptidase activator activity involved in apoptotic process
namespace: molecular_function
def: "Increases the activity of a peptidase that is involved in the apoptotic process." [GOC:BHF, GOC:mah, GOC:mtg_apoptosis, GOC:rl]
synonym: "apoptotic protease activator activity" NARROW []
is_a: GO:0016504 ! peptidase activator activity
intersection_of: GO:0016504 ! peptidase activator activity
intersection_of: part_of GO:0006915 ! apoptotic process
relationship: part_of GO:0006915 ! apoptotic process

[Term]
id: GO:0016506
name: obsolete apoptosis activator activity
namespace: molecular_function
def: "OBSOLETE. The function held by products which directly activate any step in the process of apoptosis." [GOC:hb]
comment: This term was made obsolete because it represents involvement in a biological process.
synonym: "apoptosis activator activity" EXACT []
is_obsolete: true
replaced_by: GO:0006915

[Term]
id: GO:0016507
name: mitochondrial fatty acid beta-oxidation multienzyme complex
namespace: cellular_component
def: "A complex that includes the long-chain 3-hydroxyacyl-CoA dehydrogenase and long-chain enoyl-CoA hydratase activities in two subunits (alpha and beta), catalyzing two steps of the fatty acid beta-oxidation cycle within the mitochondrial matrix." [GOC:ma]
synonym: "fatty acid beta-oxidation multienzyme complex" BROAD [GOC:imk]
synonym: "trifunctional enzyme" RELATED []
is_a: GO:0036125 ! fatty acid beta-oxidation multienzyme complex
is_a: GO:0098798 ! mitochondrial protein complex
intersection_of: GO:0036125 ! fatty acid beta-oxidation multienzyme complex
intersection_of: part_of GO:0005739 ! mitochondrion
relationship: part_of GO:0005739 ! mitochondrion
relationship: part_of GO:0005759 ! mitochondrial matrix

[Term]
id: GO:0016508
name: long-chain-enoyl-CoA hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: a long-chain (3S)-3-hydroxyacyl-CoA = a long-chain trans-2-enoyl-CoA + H2O. A long-chain acyl-CoA is an acyl-CoA thioester where the acyl chain contains 13 to 22 carbon atoms." [EC:4.2.1.74]
synonym: "long-chain enoyl coenzyme A hydratase activity" EXACT [EC:4.2.1.74]
synonym: "long-chain-(3S)-3-hydroxyacyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.74]
xref: EC:4.2.1.74
xref: MetaCyc:LONG-CHAIN-ENOYL-COA-HYDRATASE-RXN
xref: Reactome:REACT_100077 "trans-2,3-dehydrohexacosanoyl-CoA + H2O => 3-hydroxyhexacosanoyl-CoA, Gallus gallus"
xref: Reactome:REACT_101938 "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA, Saccharomyces cerevisiae"
xref: Reactome:REACT_102223 "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA, Danio rerio"
xref: Reactome:REACT_104352 "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA, Arabidopsis thaliana"
xref: Reactome:REACT_105073 "trans-2,3-dehydrohexacosanoyl-CoA + H2O => 3-hydroxyhexacosanoyl-CoA, Mus musculus"
xref: Reactome:REACT_105963 "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA, Rattus norvegicus"
xref: Reactome:REACT_106791 "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA, Bos taurus"
xref: Reactome:REACT_107128 "trans-2,3-dehydrohexacosanoyl-CoA + H2O => 3-hydroxyhexacosanoyl-CoA, Dictyostelium discoideum"
xref: Reactome:REACT_108338 "trans-2,3-dehydrohexacosanoyl-CoA + H2O => 3-hydroxyhexacosanoyl-CoA, Canis familiaris"
xref: Reactome:REACT_16908 "trans-2,3-dehydrohexacosanoyl-CoA + H2O => 3-hydroxyhexacosanoyl-CoA, Homo sapiens"
xref: Reactome:REACT_16944 "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA, Homo sapiens"
xref: Reactome:REACT_22293 "3-hydroxyoctadecanoyl-CoA => trans-octadec-2-enoyl-CoA + H2O, Homo sapiens"
xref: Reactome:REACT_28445 "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA, Canis familiaris"
xref: Reactome:REACT_28823 "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA, Oryza sativa"
xref: Reactome:REACT_29059 "trans-2,3-dehydrohexacosanoyl-CoA + H2O => 3-hydroxyhexacosanoyl-CoA, Caenorhabditis elegans"
xref: Reactome:REACT_30294 "trans-2,3-dehydrohexacosanoyl-CoA + H2O => 3-hydroxyhexacosanoyl-CoA, Danio rerio"
xref: Reactome:REACT_31566 "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA, Dictyostelium discoideum"
xref: Reactome:REACT_33517 "trans-2,3-dehydrohexacosanoyl-CoA + H2O => 3-hydroxyhexacosanoyl-CoA, Drosophila melanogaster"
xref: Reactome:REACT_77821 "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA, Xenopus tropicalis"
xref: Reactome:REACT_84328 "trans-2,3-dehydrohexacosanoyl-CoA + H2O => 3-hydroxyhexacosanoyl-CoA, Bos taurus"
xref: Reactome:REACT_84995 "trans-2,3-dehydrohexacosanoyl-CoA + H2O => 3-hydroxyhexacosanoyl-CoA, Saccharomyces cerevisiae"
xref: Reactome:REACT_91548 "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA, Gallus gallus"
xref: Reactome:REACT_94709 "trans-2,3-dehydrohexacosanoyl-CoA + H2O => 3-hydroxyhexacosanoyl-CoA, Arabidopsis thaliana"
xref: Reactome:REACT_95101 "trans-2,3-dehydrohexacosanoyl-CoA + H2O => 3-hydroxyhexacosanoyl-CoA, Taeniopygia guttata"
xref: Reactome:REACT_95957 "trans-2,3-dehydrohexacosanoyl-CoA + H2O => 3-hydroxyhexacosanoyl-CoA, Xenopus tropicalis"
xref: Reactome:REACT_96877 "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA, Drosophila melanogaster"
xref: Reactome:REACT_97946 "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA, Mus musculus"
xref: Reactome:REACT_98241 "trans-2,3-dehydrohexacosanoyl-CoA + H2O => 3-hydroxyhexacosanoyl-CoA, Oryza sativa"
xref: Reactome:REACT_99036 "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA, Taeniopygia guttata"
xref: Reactome:REACT_99339 "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA, Caenorhabditis elegans"
xref: Reactome:REACT_99964 "trans-2,3-dehydrohexacosanoyl-CoA + H2O => 3-hydroxyhexacosanoyl-CoA, Rattus norvegicus"
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0016509
name: long-chain-3-hydroxyacyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD(P)+ = 3-oxoacyl-CoA + NAD(P)H + H+, where the acyl group is a long-chain fatty acid residue. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [CHEBI:15904, EC:1.1.1.211, GOC:pde]
comment: Also see '3-hydroxyacyl-CoA dehydrogenase activity ; GO:0003857'.
subset: gosubset_prok
synonym: "beta-hydroxyacyl-CoA dehydrogenase activity" EXACT [EC:1.1.1.211]
synonym: "LCHAD" RELATED [EC:1.1.1.211]
synonym: "long-chain 3-hydroxyacyl coenzyme A dehydrogenase activity" EXACT [EC:1.1.1.211]
synonym: "long-chain-(S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.211]
xref: EC:1.1.1.211
xref: MetaCyc:1.1.1.211-RXN
xref: Reactome:REACT_22155 "3-oxooctadecanoyl-CoA (3-oxostearoyl-CoA) + NADPH + H+ => 3-hydroxyoctadecanoyl-CoA + NADP+, Homo sapiens"
is_a: GO:0003857 ! 3-hydroxyacyl-CoA dehydrogenase activity

[Term]
id: GO:0016511
name: obsolete endothelin-converting enzyme activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "endothelin-converting enzyme activity" EXACT []
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0016512
name: obsolete endothelin-converting enzyme 1 activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the formation of endothelin 1 by cleavage of the Trp21-Val22 bond in the precursor." [EC:3.4.24.71]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "ECE-1 activity" EXACT [EC:3.4.24.71]
synonym: "endothelin-converting enzyme 1 activity" EXACT []
xref: EC:3.4.24.71
xref: MetaCyc:3.4.24.71-RXN
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0016513
name: core-binding factor complex
namespace: cellular_component
def: "A heterodimeric transcription factor complex that contains an alpha subunit (Runx1, Runx2 or Runx3 in human) that binds DNA and a non-DNA-binding beta subunit (CBFbeta), and binds to a consensus sequence 5'-YGYGGTY-3' found in several enhancers and promoters; the beta subunit enhances the DNA binding of the alpha subunit." [PMID:15156179, PMID:8497254]
synonym: "AML1 complex" NARROW []
synonym: "CBF complex" EXACT []
synonym: "PEPB2 complex" NARROW []
is_a: GO:0090575 ! RNA polymerase II transcription factor complex

[Term]
id: GO:0016514
name: SWI/SNF complex
namespace: cellular_component
def: "A SWI/SNF-type complex that contains nine or more proteins, including both conserved (core) and nonconserved components; the Swi2/Snf2 ATPase is one of the core components." [GOC:mah, PMID:12672490]
synonym: "SWI-SNF complex" EXACT [GOC:mah]
is_a: GO:0090544 ! BAF-type complex

[Term]
id: GO:0016515
name: interleukin-13 receptor activity
namespace: molecular_function
def: "Combining with interleukin-13 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
synonym: "IL-13 receptor activity" EXACT [GOC:mah]
synonym: "IL-13R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity
relationship: has_part GO:0019973 ! interleukin-13 binding
relationship: part_of GO:0035772 ! interleukin-13-mediated signaling pathway

[Term]
id: GO:0016516
name: interleukin-4 receptor complex
namespace: cellular_component
def: "A protein complex that binds interleukin-4 (IL-4) and consists of an alpha chain that binds IL-4 with high affinity and a gamma common chain that also forms part of the interleukin-2 receptor." [PMID:10358772]
synonym: "IL-4 receptor complex" EXACT [GOC:add]
is_a: GO:0098802 ! plasma membrane receptor complex
relationship: part_of GO:0005887 ! integral component of plasma membrane

[Term]
id: GO:0016517
name: interleukin-12 receptor activity
namespace: molecular_function
def: "Combining with interleukin-12 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
synonym: "IL-12 receptor activity" EXACT [GOC:mah]
synonym: "IL-12R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity
relationship: has_part GO:0019972 ! interleukin-12 binding
relationship: part_of GO:0035722 ! interleukin-12-mediated signaling pathway

[Term]
id: GO:0016518
name: interleukin-14 receptor activity
namespace: molecular_function
def: "Combining with interleukin-14 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
synonym: "IL-14 receptor activity" EXACT [GOC:mah]
synonym: "IL-14R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity
relationship: has_part GO:0019974 ! interleukin-14 binding

[Term]
id: GO:0016519
name: gastric inhibitory peptide receptor activity
namespace: molecular_function
def: "Combining with gastric inhibitory peptide (GIP) and transmitting the signal across the membrane to activate an associated G-protein." [GOC:mah, PMID:8243312]
synonym: "GIP receptor activity" EXACT [PMID:19251046]
synonym: "glucose-dependent insulinotropic polypeptide receptor activity" EXACT [PMID:19251046]
is_a: GO:0004930 ! G-protein coupled receptor activity
relationship: part_of GO:0038192 ! gastric inhibitory peptide signaling pathway

[Term]
id: GO:0016520
name: growth hormone-releasing hormone receptor activity
namespace: molecular_function
def: "Combining with growth hormone-releasing hormone to initiate a change in cell activity." [PMID:12529933]
is_a: GO:0004930 ! G-protein coupled receptor activity

[Term]
id: GO:0016521
name: pituitary adenylate cyclase activating polypeptide activity
namespace: molecular_function
def: "The action characteristic of pituitary adenylate cyclase activating polypeptide, a peptide produced in the hypothalamus that binds to receptors to exert pleiotropic effects including control of neurotransmitter release, vasodilation, bronchodilation, activation of intestinal motility, increase in insulin and histamine secretion, immune modulation, and stimulation of cell proliferation and differentiation." [GOC:mah, PMID:19805477]
synonym: "pituitary adenylyl cyclase activating polypeptide activity" EXACT []
is_a: GO:0005179 ! hormone activity

[Term]
id: GO:0016524
name: latrotoxin receptor activity
namespace: molecular_function
def: "Combining with alpha-latrotoxin, a potent presynaptic neurotoxin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling, PMID:10025961]
synonym: "latrophilin" NARROW []
is_a: GO:0004888 ! transmembrane signaling receptor activity

[Term]
id: GO:0016525
name: negative regulation of angiogenesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis." [GOC:go_curators]
synonym: "down regulation of angiogenesis" EXACT []
synonym: "down-regulation of angiogenesis" EXACT []
synonym: "downregulation of angiogenesis" EXACT []
synonym: "inhibition of angiogenesis" NARROW []
is_a: GO:0045765 ! regulation of angiogenesis
is_a: GO:2000181 ! negative regulation of blood vessel morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001525 ! angiogenesis
relationship: negatively_regulates GO:0001525 ! angiogenesis

[Term]
id: GO:0016527
name: obsolete brain-specific angiogenesis inhibitor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it is based on anatomical information, and describes at least one gene product. It has also never been defined.
synonym: "brain-specific angiogenesis inhibitor activity" EXACT []
is_obsolete: true
consider: GO:0004930

[Term]
id: GO:0016528
name: sarcoplasm
namespace: cellular_component
def: "The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum." [ISBN:0198547684]
xref: Wikipedia:Sarcoplasm
is_a: GO:0005737 ! cytoplasm

[Term]
id: GO:0016529
name: sarcoplasmic reticulum
namespace: cellular_component
alt_id: GO:0008221
def: "A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage." [GOC:mtg_muscle, ISBN:0124325653, ISBN:0198547684]
comment: See also the cellular component terms 'sarcoplasm ; GO:0016528', 'nuclear envelope ; GO:0005635' and 'endoplasmic reticulum ; GO:0005783'.
xref: Wikipedia:Endoplasmic_reticulum#Sarcoplasmic_reticulum
is_a: GO:0005783 ! endoplasmic reticulum
relationship: part_of GO:0016528 ! sarcoplasm

[Term]
id: GO:0016530
name: metallochaperone activity
namespace: molecular_function
def: "Assists in the delivery of metal ions to target proteins or compartments." [GOC:jl, PMID:11739376]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0016531
name: copper chaperone activity
namespace: molecular_function
def: "Assists in the delivery of copper ions to target proteins or compartments." [PMID:10790544, PMID:11739376]
is_a: GO:0005507 ! copper ion binding
is_a: GO:0016530 ! metallochaperone activity

[Term]
id: GO:0016532
name: superoxide dismutase copper chaperone activity
namespace: molecular_function
def: "A copper chaperone activity that specifically delivers copper to the Cu-Zn superoxide dismutase, to activate superoxide dismutase activity." [GOC:vw, http://link.springer-ny.com/link/service/journals/00335/papers/0011005/00110409.html, PMID:15064408, PMID:9295278]
comment: See also the molecular function term 'superoxide dismutase activity ; GO:0004784'.
is_a: GO:0008047 ! enzyme activator activity
is_a: GO:0016531 ! copper chaperone activity
relationship: positively_regulates GO:0004784 ! superoxide dismutase activity

[Term]
id: GO:0016533
name: cyclin-dependent protein kinase 5 holoenzyme complex
namespace: cellular_component
def: "A protein complex that activates cyclin-dependent kinase 5; composed of regulatory and catalytic subunits." [PMID:15689152]
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0016534
name: cyclin-dependent protein kinase 5 activator activity
namespace: molecular_function
alt_id: GO:0016535
def: "Binds to and increases the activity of cyclin-dependent protein kinase 5." [GOC:mah]
synonym: "cyclin-dependent protein kinase 5 activator, intrinsic catalyst activity" EXACT []
is_a: GO:0043539 ! protein serine/threonine kinase activator activity

[Term]
id: GO:0016536
name: obsolete cyclin-dependent protein kinase 5 activator regulator activity
namespace: molecular_function
def: "OBSOLETE. Modulation of the activity of cyclin-dependent protein kinase 5 activator." [GOC:ai]
comment: This term was made obsolete because it refers to a specific gene product.
synonym: "cyclin-dependent protein kinase 5 activator regulator activity" EXACT []
synonym: "cyclin-dependent protein kinase 5 activator, intrinsic regulator activity" NARROW []
is_obsolete: true

[Term]
id: GO:0016538
name: cyclin-dependent protein serine/threonine kinase regulator activity
namespace: molecular_function
alt_id: GO:0003751
alt_id: GO:0003752
alt_id: GO:0003753
def: "Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins." [GOC:pr, GOC:rn, PMID:7877684, PMID:9442875]
synonym: "cyclin" BROAD []
synonym: "cyclin-dependent protein kinase regulator activity" BROAD []
synonym: "cyclin-dependent protein kinase, intrinsic regulator activity" NARROW []
synonym: "G1/S-specific cyclin" NARROW []
synonym: "G2/M-specific cyclin" NARROW []
xref: EC:2.7.1.-
is_a: GO:0019887 ! protein kinase regulator activity
relationship: regulates GO:0004693 ! cyclin-dependent protein serine/threonine kinase activity

[Term]
id: GO:0016539
name: intein-mediated protein splicing
namespace: biological_process
def: "The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues." [GOC:ma, http://www.neb.com/neb/inteins.html]
subset: gosubset_prok
synonym: "intein" RELATED []
is_a: GO:0030908 ! protein splicing

[Term]
id: GO:0016540
name: protein autoprocessing
namespace: biological_process
def: "Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein." [GOC:ai, PMID:9335337]
subset: goslim_chembl
subset: gosubset_prok
is_a: GO:0016485 ! protein processing

[Term]
id: GO:0016541
name: obsolete intein
namespace: molecular_function
def: "OBSOLETE. Intervening protein sequence excised from a protein precursor in protein splicing; inteins catalyze their own excision and many also possess endonuclease activity." [GOC:mah, http://www.neb.com/neb/inteins.html, PMID:8165123]
comment: This term was made obsolete because it refers to a protein sequence feature.
synonym: "intein" EXACT []
is_obsolete: true
consider: GO:0004519
consider: GO:0016539

[Term]
id: GO:0016543
name: male courtship behavior, orientation prior to leg tapping and wing vibration
namespace: biological_process
def: "The process during courtship, where the male orients towards a potential partner. An example of this is found in Drosophila melanogaster." [GOC:sensu, PMID:11092827]
synonym: "male courtship behavior, orientation" RELATED []
synonym: "male courtship behaviour, orientation" RELATED []
synonym: "male courtship behaviour, orientation prior to leg tapping and wing vibration" RELATED []
is_a: GO:0008049 ! male courtship behavior

[Term]
id: GO:0016544
name: male courtship behavior, tapping to detect pheromone
namespace: biological_process
def: "The process during courtship where the male insect taps the female with his frontal leg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11092827]
synonym: "male courtship behavior, tapping" RELATED []
synonym: "male courtship behaviour, tapping" EXACT []
synonym: "male courtship behaviour, tapping to detect pheromone" RELATED []
is_a: GO:0008049 ! male courtship behavior

[Term]
id: GO:0016545
name: male courtship behavior, veined wing vibration
namespace: biological_process
def: "The process during courtship where the male insect vibrates his wings. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11092827]
synonym: "male courtship behavior, wing vibration" RELATED []
synonym: "male courtship behaviour, veined wing vibration" EXACT []
synonym: "male courtship behaviour, wing vibration" RELATED []
is_a: GO:0048065 ! male courtship behavior, veined wing extension

[Term]
id: GO:0016546
name: male courtship behavior, proboscis-mediated licking
namespace: biological_process
def: "The process during courtship where the male fly licks the genitalia of a stationary female fly with his proboscis. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11092827]
synonym: "male courtship behavior, licking" RELATED []
synonym: "male courtship behaviour, licking" RELATED []
synonym: "male courtship behaviour, proboscis-mediated licking" EXACT []
is_a: GO:0008049 ! male courtship behavior

[Term]
id: GO:0016550
name: obsolete insertion or deletion editing
namespace: biological_process
def: "OBSOLETE. The insertion into or deletion from an RNA molecule of nucleotide residues not encoded in DNA; takes place during or after transcription." [PMID:11092837]
comment: This term was made obsolete because it represents two separate processes (insertion and deletion).
synonym: "insertion or deletion editing" EXACT []
synonym: "insertion/deletion editing" EXACT []
is_obsolete: true
consider: GO:0070705
consider: GO:0070706

[Term]
id: GO:0016551
name: obsolete posttranscriptional insertion or deletion editing
namespace: biological_process
def: "OBSOLETE. The insertion into or deletion from an RNA molecule of nucleotide residues not encoded in DNA; takes place after transcription." [PMID:11092837]
comment: This term was made obsolete because it represents two separate processes (insertion and deletion).
synonym: "posttranscriptional insertion or deletion editing" EXACT []
synonym: "posttranscriptional insertion/deletion editing" EXACT []
is_obsolete: true
consider: GO:0070705
consider: GO:0070706

[Term]
id: GO:0016552
name: obsolete cotranscriptional insertion or deletion editing
namespace: biological_process
def: "OBSOLETE. The insertion into or deletion from an RNA molecule of nucleotide residues not encoded in DNA; takes place during transcription." [PMID:11092837]
comment: This term was made obsolete because it represents two separate processes (insertion and deletion).
synonym: "cotranscriptional insertion or deletion editing" EXACT []
synonym: "cotranscriptional insertion/deletion editing" EXACT []
is_obsolete: true
consider: GO:0070705
consider: GO:0070706

[Term]
id: GO:0016553
name: base conversion or substitution editing
namespace: biological_process
def: "Any base modification or substitution events that result in alterations in the coding potential or structural properties of RNAs as a result of changes in the base-pairing properties of the modified ribonucleoside(s)." [PMID:11092837]
subset: gosubset_prok
synonym: "base conversion/substitution editing" EXACT []
is_a: GO:0009451 ! RNA modification

[Term]
id: GO:0016554
name: cytidine to uridine editing
namespace: biological_process
def: "The conversion of a cytosine residue to uridine in an RNA molecule by deamination." [PMID:11092837]
subset: gosubset_prok
xref: Reactome:REACT_102193 "mRNA Editing: C to U Conversion, Xenopus tropicalis"
xref: Reactome:REACT_102796 "mRNA Editing: C to U Conversion, Arabidopsis thaliana"
xref: Reactome:REACT_103895 "mRNA Editing: C to U Conversion, Oryza sativa"
xref: Reactome:REACT_105757 "mRNA Editing: C to U Conversion, Gallus gallus"
xref: Reactome:REACT_107650 "mRNA Editing: C to U Conversion, Rattus norvegicus"
xref: Reactome:REACT_109030 "mRNA Editing: C to U Conversion, Canis familiaris"
xref: Reactome:REACT_167 "mRNA Editing: C to U Conversion, Homo sapiens"
xref: Reactome:REACT_34729 "mRNA Editing: C to U Conversion, Dictyostelium discoideum"
xref: Reactome:REACT_81634 "mRNA Editing: C to U Conversion, Bos taurus"
xref: Reactome:REACT_84155 "mRNA Editing: C to U Conversion, Sus scrofa"
xref: Reactome:REACT_88552 "mRNA Editing: C to U Conversion, Danio rerio"
xref: Reactome:REACT_94358 "mRNA Editing: C to U Conversion, Taeniopygia guttata"
xref: Reactome:REACT_96426 "mRNA Editing: C to U Conversion, Mus musculus"
is_a: GO:0016553 ! base conversion or substitution editing

[Term]
id: GO:0016555
name: uridine to cytidine editing
namespace: biological_process
def: "The conversion of a uridine residue to cytosine in an RNA molecule by amination." [PMID:11092837]
subset: gosubset_prok
is_a: GO:0016553 ! base conversion or substitution editing

[Term]
id: GO:0016556
name: mRNA modification
namespace: biological_process
alt_id: GO:0006381
def: "The covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]
comment: The term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing. Parallel changes were made for substrate (e.g. tRNA, rRNA, etc.) specific child terms of 'RNA editing'.
subset: gosubset_prok
synonym: "mRNA editing" NARROW [GOC:dph, GOC:hjd, GOC:tb]
xref: Reactome:REACT_100618 "mRNA Editing, Taeniopygia guttata"
xref: Reactome:REACT_100905 "mRNA Editing, Oryza sativa"
xref: Reactome:REACT_113194 "mRNA Editing, Caenorhabditis elegans"
xref: Reactome:REACT_114458 "mRNA Editing, Schizosaccharomyces pombe"
xref: Reactome:REACT_114695 "mRNA Editing, Saccharomyces cerevisiae"
xref: Reactome:REACT_1757 "mRNA Editing, Homo sapiens"
xref: Reactome:REACT_28944 "mRNA Editing, Mus musculus"
xref: Reactome:REACT_29117 "mRNA Editing, Sus scrofa"
xref: Reactome:REACT_33029 "mRNA Editing, Gallus gallus"
xref: Reactome:REACT_33947 "mRNA Editing, Xenopus tropicalis"
xref: Reactome:REACT_47394 "mRNA Editing, Dictyostelium discoideum"
xref: Reactome:REACT_81752 "mRNA Editing, Danio rerio"
xref: Reactome:REACT_85035 "mRNA Editing, Arabidopsis thaliana"
xref: Reactome:REACT_91114 "mRNA Editing, Canis familiaris"
xref: Reactome:REACT_91790 "mRNA Editing, Drosophila melanogaster"
xref: Reactome:REACT_94500 "mRNA Editing, Bos taurus"
xref: Reactome:REACT_98313 "mRNA Editing, Rattus norvegicus"
is_a: GO:0009451 ! RNA modification
is_a: GO:0016071 ! mRNA metabolic process

[Term]
id: GO:0016557
name: peroxisome membrane biogenesis
namespace: biological_process
def: "The process in which a peroxisome membrane is synthesized, aggregates, and bonds together." [GOC:mah]
is_a: GO:0044091 ! membrane biogenesis
relationship: part_of GO:0007031 ! peroxisome organization

[Term]
id: GO:0016558
name: protein import into peroxisome matrix
namespace: biological_process
def: "The import of proteins into the peroxisomal matrix. A peroxisome targeting signal (PTS) binds to a soluble receptor protein in the cytosol, and the resulting complex then binds to a receptor protein in the peroxisome membrane and is imported. The cargo protein is then released into the peroxisome matrix." [ISBN:0716731363, PMID:11687502, PMID:11988772]
synonym: "peroxisome matrix protein import" EXACT []
synonym: "protein transport to peroxisome matrix" EXACT []
is_a: GO:0006625 ! protein targeting to peroxisome
is_a: GO:0044743 ! intracellular protein transmembrane import

[Term]
id: GO:0016559
name: peroxisome fission
namespace: biological_process
def: "The division of a mature peroxisome within a cell to form two or more separate peroxisome compartments." [GOC:mah, PMID:11687502, PMID:14754507]
synonym: "peroxisome division" EXACT []
synonym: "peroxisome proliferation" EXACT []
is_a: GO:0048285 ! organelle fission
relationship: part_of GO:0007031 ! peroxisome organization

[Term]
id: GO:0016560
name: protein import into peroxisome matrix, docking
namespace: biological_process
def: "The process in which a complex formed of a peroxisome targeting sequence (PTS) receptor bound to a PTS-bearing protein docks with translocation machinery in the peroxisomal membrane." [PMID:11687502, PMID:11988772, PMID:14754507]
synonym: "peroxisome matrix protein import, docking" EXACT []
synonym: "peroxisome receptor docking" RELATED []
synonym: "protein docking during peroxisome matrix protein import" EXACT []
synonym: "protein docking during protein import into peroxisome matrix" EXACT []
synonym: "protein docking during protein transport into peroxisome matrix" EXACT []
synonym: "protein transport into peroxisome matrix, docking" EXACT []
is_a: GO:0022615 ! protein to membrane docking
relationship: part_of GO:0016558 ! protein import into peroxisome matrix

[Term]
id: GO:0016561
name: protein import into peroxisome matrix, translocation
namespace: biological_process
def: "The process in which proteins are moved across the peroxisomal membrane into the matrix. It is likely that the peroxisome targeting sequence receptor remains associated with cargo proteins during translocation." [PMID:11687502]
synonym: "peroxisome matrix protein import, translocation" EXACT []
synonym: "peroxisome receptor translocation" RELATED []
synonym: "protein translocation during peroxisome matrix protein import" EXACT []
synonym: "protein translocation during protein import into peroxisome matrix" EXACT []
synonym: "protein translocation during protein transport into peroxisome matrix" EXACT []
synonym: "protein transport into peroxisome matrix, translocation" EXACT []
is_a: GO:0065002 ! intracellular protein transmembrane transport
relationship: part_of GO:0016558 ! protein import into peroxisome matrix

[Term]
id: GO:0016562
name: protein import into peroxisome matrix, receptor recycling
namespace: biological_process
def: "The process in which peroxisome targeting sequence receptors dissociates from cargo proteins and are returned to the cytosol." [PMID:11687502]
synonym: "peroxisome matrix protein import, receptor recycling" EXACT []
synonym: "peroxisome receptor recycling" RELATED []
synonym: "protein transport into peroxisome matrix, receptor recycling" EXACT []
synonym: "PTS receptor recycling" RELATED []
synonym: "receptor recycling during peroxisome matrix protein import" EXACT []
synonym: "receptor recycling during protein import into peroxisome matrix" EXACT []
synonym: "receptor recycling during protein transport into peroxisome matrix" EXACT []
is_a: GO:0001881 ! receptor recycling
intersection_of: GO:0001881 ! receptor recycling
intersection_of: part_of GO:0016558 ! protein import into peroxisome matrix
relationship: part_of GO:0016558 ! protein import into peroxisome matrix

[Term]
id: GO:0016563
name: obsolete transcription activator activity
namespace: molecular_function
alt_id: GO:0003710
def: "OBSOLETE. Any transcription regulator activity required for initiation or upregulation of transcription." [GOC:jl, ISBN:0124325653]
comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
subset: gosubset_prok
synonym: "transcription activating factor" NARROW []
synonym: "transcription activator activity" EXACT []
synonym: "transcriptional activator activity" EXACT []
is_obsolete: true
consider: GO:0000988
consider: GO:0001071
consider: GO:0045893

[Term]
id: GO:0016564
name: obsolete transcription repressor activity
namespace: molecular_function
def: "OBSOLETE. Any transcription regulator activity that prevents or downregulates transcription." [GOC:mah]
comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
subset: gosubset_prok
synonym: "negative transcriptional regulator activity" EXACT []
synonym: "transcription repressor activity" EXACT []
synonym: "transcriptional repressor activity" EXACT []
is_obsolete: true
consider: GO:0000988
consider: GO:0001071
consider: GO:0045892

[Term]
id: GO:0016565
name: obsolete general transcriptional repressor activity
namespace: molecular_function
def: "OBSOLETE. Any activity that stops or downregulates transcription of genes globally, and is not specific to a particular gene or gene set." [GOC:mah]
comment: This term was obsoleted because "general/nonspecific/basal" transcription vs "specific" transcription were determined not to be separable, distinct process. Thus, terms trying to distinguish "general/nonspecific/basal" transcription from "specific" transcription were removed from both the Molecular Function and the Biological Process ontologies. In addition, this Molecular Function term was defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of your repressor is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
synonym: "general transcriptional repressor activity" EXACT []
is_obsolete: true
consider: GO:0001078
consider: GO:0001141
consider: GO:0045892

[Term]
id: GO:0016566
name: obsolete specific transcriptional repressor activity
namespace: molecular_function
def: "OBSOLETE. Any activity that stops or downregulates transcription of specific genes or sets of genes." [GOC:mah]
comment: This term was obsoleted because "general/nonspecific/basal" transcription vs "specific" transcription were determined not to be separable, distinct process. Thus, terms trying to distinguish "general/nonspecific/basal" transcription from "specific" transcription were removed from both the Molecular Function and the Biological Process ontologies. In addition, this Molecular Function term was defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of your repressor is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
subset: gosubset_prok
synonym: "specific transcriptional repressor activity" EXACT []
is_obsolete: true
consider: GO:0001078
consider: GO:0001141
consider: GO:0045892

[Term]
id: GO:0016567
name: protein ubiquitination
namespace: biological_process
def: "The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]
synonym: "protein ubiquitinylation" EXACT []
synonym: "protein ubiquitylation" EXACT []
is_a: GO:0032446 ! protein modification by small protein conjugation

[Term]
id: GO:0016568
name: chromatin modification
namespace: biological_process
def: "The alteration of DNA, protein, or sometimes RNA, in chromatin, which may result in changing the chromatin structure." [GOC:mah, PMID:20404130]
is_a: GO:0006325 ! chromatin organization

[Term]
id: GO:0016569
name: covalent chromatin modification
namespace: biological_process
def: "The alteration of DNA or protein in chromatin by the covalent addition or removal of chemical groups." [GOC:mah]
is_a: GO:0016568 ! chromatin modification

[Term]
id: GO:0016570
name: histone modification
namespace: biological_process
def: "The covalent alteration of one or more amino acid residues within a histone protein." [GOC:krc]
subset: goslim_yeast
xref: Wikipedia:Histone#Histone_modifications_in_chromatin_regulation
is_a: GO:0006464 ! cellular protein modification process
is_a: GO:0016569 ! covalent chromatin modification
is_a: GO:0044710 ! single-organism metabolic process
is_a: GO:1902589 ! single-organism organelle organization

[Term]
id: GO:0016571
name: histone methylation
namespace: biological_process
def: "The modification of histones by addition of methyl groups." [GOC:ai]
xref: Wikipedia:Histone_methylation
is_a: GO:0006479 ! protein methylation
is_a: GO:0016570 ! histone modification

[Term]
id: GO:0016572
name: histone phosphorylation
namespace: biological_process
def: "The modification of histones by addition of phosphate groups." [GOC:ai]
is_a: GO:0006468 ! protein phosphorylation
is_a: GO:0016570 ! histone modification

[Term]
id: GO:0016573
name: histone acetylation
namespace: biological_process
def: "The modification of a histone by the addition of an acetyl group." [GOC:ai]
is_a: GO:0016570 ! histone modification
is_a: GO:0018393 ! internal peptidyl-lysine acetylation

[Term]
id: GO:0016574
name: histone ubiquitination
namespace: biological_process
def: "The modification of histones by addition of ubiquitin groups." [GOC:ai]
synonym: "histone ubiquitinylation" EXACT []
synonym: "histone ubiquitylation" EXACT []
is_a: GO:0016567 ! protein ubiquitination
is_a: GO:0016570 ! histone modification

[Term]
id: GO:0016575
name: histone deacetylation
namespace: biological_process
def: "The modification of histones by removal of acetyl groups." [GOC:ai]
is_a: GO:0006476 ! protein deacetylation
is_a: GO:0016570 ! histone modification

[Term]
id: GO:0016576
name: histone dephosphorylation
namespace: biological_process
def: "The modification of histones by removal of phosphate groups." [GOC:ai]
is_a: GO:0006470 ! protein dephosphorylation
is_a: GO:0016570 ! histone modification

[Term]
id: GO:0016577
name: histone demethylation
namespace: biological_process
def: "The modification of histones by removal of methyl groups." [GOC:ai]
is_a: GO:0006482 ! protein demethylation
is_a: GO:0016570 ! histone modification

[Term]
id: GO:0016578
name: histone deubiquitination
namespace: biological_process
def: "The modification of histones by removal of ubiquitin groups." [GOC:ai]
synonym: "histone deubiquitinylation" EXACT []
synonym: "histone deubiquitylation" EXACT []
is_a: GO:0016570 ! histone modification
is_a: GO:0016579 ! protein deubiquitination

[Term]
id: GO:0016579
name: protein deubiquitination
namespace: biological_process
alt_id: GO:0006514
def: "The removal of one or more ubiquitin groups from a protein." [GOC:ai]
synonym: "deubiquitination" EXACT []
synonym: "protein deubiquitinylation" EXACT []
synonym: "protein deubiquitylation" EXACT []
is_a: GO:0070646 ! protein modification by small protein removal
relationship: has_part GO:0004843 ! thiol-dependent ubiquitin-specific protease activity

[Term]
id: GO:0016580
name: Sin3 complex
namespace: cellular_component
def: "A multiprotein complex that functions broadly in eukaryotic organisms as a transcriptional repressor of protein-coding genes, through the gene-specific deacetylation of histones. Amongst its subunits, the Sin3 complex contains Sin3-like proteins, and a number of core proteins that are shared with the NuRD complex (including histone deacetylases and histone binding proteins). The Sin3 complex does not directly bind DNA itself, but is targeted to specific genes through protein-protein interactions with DNA-binding proteins." [PMID:10589671, PMID:11743021, PMID:12865422]
is_a: GO:0070822 ! Sin3-type complex

[Term]
id: GO:0016581
name: NuRD complex
namespace: cellular_component
def: "An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins." [PMID:10589671, PMID:11743021, PMID:17289569]
synonym: "Mi-2 complex" EXACT []
synonym: "NRD complex" EXACT []
synonym: "nucleosome remodeling and histone deacetylation complex" EXACT []
is_a: GO:0000118 ! histone deacetylase complex
is_a: GO:0090545 ! CHD-type complex
is_a: GO:0090568 ! nuclear transcriptional repressor complex

[Term]
id: GO:0016582
name: non-covalent chromatin modification
namespace: biological_process
def: "The alteration of DNA or protein in chromatin by the non-covalent addition or removal of chemical groups." [GOC:jl]
is_a: GO:0016568 ! chromatin modification

[Term]
id: GO:0016583
name: obsolete nucleosome modeling
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it has been replaced by more specific terms.
synonym: "nucleosome modeling" EXACT []
is_obsolete: true
consider: GO:0006334

[Term]
id: GO:0016584
name: nucleosome positioning
namespace: biological_process
def: "Ordering of successions of nucleosomes into regular arrays so that nucleosomes are positioned at defined distances from one another." [GOC:bf, PMID:11447119, PMID:8676389]
synonym: "nucleosome spacing" EXACT []
is_a: GO:0031497 ! chromatin assembly
is_a: GO:0034728 ! nucleosome organization

[Term]
id: GO:0016585
name: obsolete chromatin remodeling complex
namespace: cellular_component
alt_id: GO:0005679
def: "OBSOLETE: Any complex that mediates dynamic changes in eukaryotic chromatin." [GOC:mah]
comment: This term was made obsolete because its definition no longer reflects and cannot be modified to be consistent with the current state of knowledge.
subset: goslim_pir
synonym: "chromatin remodeling complex" EXACT []
synonym: "chromatin remodelling complex" EXACT []
synonym: "nucleosome remodeling complex" EXACT []
is_obsolete: true
consider: GO:0006338

[Term]
id: GO:0016586
name: RSC complex
namespace: cellular_component
def: "A protein complex similar to, but more abundant than, the Swi/Snf complex. The RSC complex is generally recruited to RNA polymerase III promoters and is specifically recruited to RNA polymerase II promoters by transcriptional activators and repressors; it is also involved in non-homologous end joining." [GOC:rb, PMID:11937489, PMID:12672490, PMID:15870268, PMID:19355820, PMID:8980231]
is_a: GO:0070603 ! SWI/SNF superfamily-type complex

[Term]
id: GO:0016587
name: Isw1 complex
namespace: cellular_component
def: "A protein complex that contains an Isw1 subunit from the ISWI-family of ATPases and acts to modify chromatin structure." [GOC:krc, GOC:mah, PMID:15020051, PMID:15284901, PMID:16568949, PMID:21810179]
is_a: GO:0031010 ! ISWI-type complex

[Term]
id: GO:0016589
name: NURF complex
namespace: cellular_component
def: "An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2L in mammals), a NURF301 homolog (BPTF in humans), and additional subunits, though the composition of these additional subunits varies slightly with species. NURF is involved in regulation of transcription from TRNA polymerase II promoters." [GOC:bf, GOC:krc, PMID:10779516, PMID:11279013, PMID:15284901, PMID:16568949, PMID:21810179]
synonym: "nucleosome remodeling factor complex" EXACT []
is_a: GO:0031010 ! ISWI-type complex

[Term]
id: GO:0016590
name: ACF complex
namespace: cellular_component
def: "An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals, Isw2 in S. cerevisiae), an ACF1 homolog, and generally no other subunits, though Xenopus is an exception with a third non-conserved subunit. ACF plays roles in regulation of RNA polymerase II transcription and in DNA replication and repair." [GOC:bf, GOC:krc, PMID:12192034, PMID:15284901, PMID:16568949, PMID:21810179]
synonym: "ATP-utilizing chromatin assembly and remodeling factor complex" EXACT []
is_a: GO:0031010 ! ISWI-type complex

[Term]
id: GO:0016591
name: DNA-directed RNA polymerase II, holoenzyme
namespace: cellular_component
def: "Large protein complex composed of the RNA polymerase core complex and a variety of other proteins including transcription factor complexes TFIIA, D, E, F, and H which are required for promoter recognition, and the Mediator subcomplex. Catalyzes the synthesis of eukaryotic pre-mRNA." [GOC:jl, PMID:15196470, Wikipedia:Rna_polymerase_ii]
subset: goslim_pir
is_a: GO:0044451 ! nucleoplasm part
is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex

[Term]
id: GO:0016592
name: mediator complex
namespace: cellular_component
alt_id: GO:0000119
def: "A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]
synonym: "CDK8-containing TRAP/mediator complex" RELATED []
synonym: "L mediator complex" EXACT []
synonym: "Srb-mediator complex" EXACT [GOC:mah]
synonym: "TRAP complex" NARROW []
xref: Wikipedia:Mediator_(coactivator)
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part
relationship: has_part GO:0070847 ! core mediator complex

[Term]
id: GO:0016593
name: Cdc73/Paf1 complex
namespace: cellular_component
def: "A multiprotein complex that associates with RNA polymerase II and general RNA polymerase II transcription factor complexes and may be involved in both transcriptional initiation and elongation. In Saccharomyces the complex contains Paf1p, Cdc73p, Ctr9p, Rtf1p, and Leo1p." [PMID:11884586]
synonym: "Paf1 complex" EXACT [GOC:cjk]
synonym: "Paf1p complex" EXACT [GOC:cjk]
is_a: GO:0008023 ! transcription elongation factor complex
relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme

[Term]
id: GO:0016594
name: glycine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with glycine, aminoethanoic acid." [GOC:ai]
synonym: "aminoacetic acid binding" EXACT []
synonym: "aminoethanoic acid binding" EXACT []
synonym: "Gly binding" EXACT []
is_a: GO:0016597 ! amino acid binding
is_a: GO:0043169 ! cation binding

[Term]
id: GO:0016595
name: glutamate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with glutamate, the anion of 2-aminopentanedioic acid." [GOC:ai]
synonym: "glutamic acid binding" EXACT []
is_a: GO:0016597 ! amino acid binding

[Term]
id: GO:0016596
name: thienylcyclohexylpiperidine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with thienylcyclohexylpiperidine." [GOC:jl]
synonym: "TCP binding" BROAD []
is_a: GO:0008144 ! drug binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding
is_a: GO:1901681 ! sulfur compound binding

[Term]
id: GO:0016597
name: amino acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0031406 ! carboxylic acid binding

[Term]
id: GO:0016598
name: protein arginylation
namespace: biological_process
alt_id: GO:0019130
def: "The conjugation of arginine to the N-terminal aspartate or glutamate of a protein; required for the degradation of the protein via the ubiquitin pathway." [PMID:17896865]
synonym: "protein amino acid arginylation" EXACT []
is_a: GO:0006464 ! cellular protein modification process
relationship: part_of GO:0006511 ! ubiquitin-dependent protein catabolic process

[Term]
id: GO:0016600
name: flotillin complex
namespace: cellular_component
def: "A protein complex that contains flotillin-1 and flotillin-2, and may contain associated proteins. Flotillins associate into membrane microdomains resembling caveolae." [PMID:17206938, PMID:17600709]
comment: See also the cellular component term 'caveola ; GO:0005901'.
is_a: GO:0098797 ! plasma membrane protein complex
relationship: part_of GO:0005901 ! caveola

[Term]
id: GO:0016601
name: Rac protein signal transduction
namespace: biological_process
def: "A series of molecular signals within the cell that are mediated by a member of the Rac family of proteins switching to a GTP-bound active state." [GOC:bf]
synonym: "Rac mediated signal transduction" EXACT []
is_a: GO:0007265 ! Ras protein signal transduction

[Term]
id: GO:0016602
name: CCAAT-binding factor complex
namespace: cellular_component
def: "A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; functions as both an activator and a repressor, depending on its interacting cofactors. Typically trimeric consisting of NFYA, NFYB and NFYC subunits. In Saccharomyces, it activates the transcription of genes in response to growth in a nonfermentable carbon source and consists of four known subunits: HAP2, HAP3, HAP4 and HAP5." [GOC:bm, PMID:7828851]
synonym: "CBF complex" RELATED [GOC:bm]
synonym: "NF-Y transcription factor complex" RELATED [GOC:bm]
synonym: "nuclear transcription factor Y complex" RELATED [GOC:bm]
is_a: GO:0090575 ! RNA polymerase II transcription factor complex

[Term]
id: GO:0016603
name: glutaminyl-peptide cyclotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH3." [EC:2.3.2.5]
subset: gosubset_prok
synonym: "glutaminyl cyclase activity" EXACT [EC:2.3.2.5]
synonym: "glutaminyl-transfer ribonucleate cyclotransferase activity" EXACT [EC:2.3.2.5]
synonym: "glutaminyl-tRNA cyclotransferase activity" NARROW [EC:2.3.2.5]
synonym: "L-glutaminyl-peptide gamma-glutamyltransferase (cyclizing)" EXACT [EC:2.3.2.5]
xref: EC:2.3.2.5
xref: MetaCyc:GLUTAMINYL-PEPTIDE-CYCLOTRANSFERASE-RXN
is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups

[Term]
id: GO:0016604
name: nuclear body
namespace: cellular_component
def: "Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:ma, PMID:10330182]
xref: NIF_Subcellular:sao505137457
is_a: GO:0044451 ! nucleoplasm part

[Term]
id: GO:0016605
name: PML body
namespace: cellular_component
def: "A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection." [GOC:ma, PMID:10944585]
synonym: "ND10" EXACT []
synonym: "nuclear dot" RELATED []
synonym: "PML NB" EXACT []
synonym: "PML nuclear body" EXACT []
is_a: GO:0016604 ! nuclear body

[Term]
id: GO:0016606
name: LYSP100-associated nuclear domain
namespace: cellular_component
def: "A nuclear body that is enriched in the lymphoid cell-specific protein LYSp100B; LANDs are globular, electron-dense structures and are morphologically distinct from the annular structures characteristic of PML bodies." [PMID:10921892, PMID:8695863]
synonym: "LANDs" EXACT [PMID:8695863]
is_a: GO:0016604 ! nuclear body

[Term]
id: GO:0016607
name: nuclear speck
namespace: cellular_component
def: "A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/]
synonym: "nuclear speckle" EXACT []
synonym: "nuclear speckles" EXACT []
synonym: "speckle domain" NARROW []
synonym: "speckle focus" RELATED []
synonym: "splicing speckle" EXACT []
is_a: GO:0016604 ! nuclear body

[Term]
id: GO:0016608
name: growth hormone-releasing hormone activity
namespace: molecular_function
def: "The action characteristic of growth hormone-releasing hormone, any of a family of peptide hormones that act on the anterior pituitary to stimulate the secretion of growth hormone and exert a trophic effect on the gland." [ISBN:0198506732]
synonym: "GHRF activity" EXACT [ISBN:0198506732]
synonym: "GHRH activity" EXACT [ISBN:0198506732]
is_a: GO:0005179 ! hormone activity

[Term]
id: GO:0016610
name: nitrogenase complex
namespace: cellular_component
def: "An enzyme complex composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase is tetrameric with an alpha2-beta2 structure and nitrogenase reductase is a homodimer, and both are associated with metal ions, which differ between species. Both proteins are required for the enzyme activity of the complex, the formation of oxidized ferredoxin and ammonia from reduced ferredoxin and nitrogen." [EC:1.18.6.1, MetaCyc:CPLX-186, MetaCyc:CPLX-525]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0044424 ! intracellular part
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:0016611
name: iron-iron nitrogenase complex
namespace: cellular_component
def: "An enzyme complex containing an iron-iron cluster found in species such as the photosynthetic bacterium Rhodobacter capsulatus. It is composed of two main subunits, dinitrogenase and nitrogenase reductase. Dinitrogenase, the iron-iron containing subunit, has an alpha1-beta2 or alpha2-beta2 structure, and the nitrogenase reductase subunit is a homodimer. Functions in the catalysis of the formation of oxidized ferredoxin and ammonia from reduced ferredoxin and nitrogen." [EC:1.18.6.1, GOC:jl, PMID:11848850]
comment: Note that it is not established whether the nitrogenase exists in vivo in a specific particle or whether the nitrogenase proteins are bound nonspecifically to the membranes of some cells.
subset: gosubset_prok
is_a: GO:0016610 ! nitrogenase complex

[Term]
id: GO:0016612
name: molybdenum-iron nitrogenase complex
namespace: cellular_component
def: "An enzyme complex containing a molybdenum-iron cluster found in many species. It is composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase, the molybdenum-iron protein, is tetrameric with an alpha2-beta2 structure, and nitrogenase reductase is a homodimer." [EC:1.18.6.1]
subset: gosubset_prok
synonym: "molybdenum-iron nitrogenase activity" RELATED []
is_a: GO:0016610 ! nitrogenase complex

[Term]
id: GO:0016613
name: vanadium-iron nitrogenase complex
namespace: cellular_component
def: "An enzyme complex containing a vanadium-iron cluster found in some species, such as Azotobacter vinelandii. It is composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase, the vanadium-iron protein, is tetrameric with an alpha2-beta2 structure, and nitrogenase reductase is a homodimer." [EC:1.18.6.1, PMID:3474027]
subset: gosubset_prok
synonym: "vanadium-iron nitrogenase activity" RELATED []
is_a: GO:0016610 ! nitrogenase complex

[Term]
id: GO:0016614
name: oxidoreductase activity, acting on CH-OH group of donors
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
comment: Note that enzymes of class EC:1.1.99.- should also be annotated to this term.
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on the CH-OH group of donors, other acceptors" NARROW []
xref: EC:1.1
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016615
name: malate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate." [GOC:mah, ISBN:0582227089]
subset: gosubset_prok
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0016616
name: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]
subset: gosubset_prok
xref: EC:1.1.1
xref: Reactome:REACT_25000 "Reduction of retinal to retinol in enterocytes, Homo sapiens"
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0016617
name: 4-oxoproline reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxy-L-proline + NAD+ = 4-oxoproline + NADH + H+." [EC:1.1.1.104]
synonym: "4-hydroxy-L-proline:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.104]
synonym: "hydroxy-L-proline oxidase activity" EXACT []
synonym: "hydroxyproline oxidase activity" EXACT [EC:1.1.1.104]
xref: EC:1.1.1.104
xref: MetaCyc:4-OXOPROLINE-REDUCTASE-RXN
xref: RHEA:13604
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0016618
name: hydroxypyruvate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glycerate + NADP+ = hydroxypyruvate + NADPH + H+." [EC:1.1.1.81]
subset: gosubset_prok
synonym: "beta-hydroxypyruvate reductase activity" EXACT [EC:1.1.1.81]
synonym: "D-glycerate dehydrogenase activity" EXACT [EC:1.1.1.81]
synonym: "D-glycerate:NADP+ 2-oxidoreductase activity" EXACT [EC:1.1.1.81]
synonym: "NADH:hydroxypyruvate reductase activity" EXACT [EC:1.1.1.81]
xref: EC:1.1.1.81
xref: MetaCyc:HYDROXYPYRUVATE-REDUCTASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0016620
name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]
subset: gosubset_prok
xref: EC:1.2.1
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0016621
name: cinnamoyl-CoA reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: cinnamaldehyde + CoA + NADP+ = cinnamoyl-CoA + NADPH + H+." [EC:1.2.1.44]
synonym: "cinnamaldehyde:NADP+ oxidoreductase (CoA-cinnamoylating)" EXACT [EC:1.2.1.44]
synonym: "cinnamoyl CoA reductase activity" EXACT []
synonym: "cinnamoyl-CoA:NADPH reductase activity" EXACT [EC:1.2.1.44]
synonym: "cinnamoyl-coenzyme A reductase activity" EXACT [EC:1.2.1.44]
synonym: "feruloyl coenzyme A reductase activity" EXACT [EC:1.2.1.44]
synonym: "feruloyl-CoA reductase activity" EXACT [EC:1.2.1.44]
synonym: "ferulyl-CoA reductase activity" EXACT [EC:1.2.1.44]
synonym: "p-hydroxycinnamoyl coenzyme A reductase activity" EXACT [EC:1.2.1.44]
xref: EC:1.2.1.44
xref: MetaCyc:CINNAMOYL-COA-REDUCTASE-RXN
xref: RHEA:10623
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0016622
name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a cytochrome." [GOC:jl]
subset: gosubset_prok
xref: EC:1.2.2
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0016623
name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl]
subset: gosubset_prok
xref: EC:1.2.3
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0016624
name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide." [GOC:jl]
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulphide as acceptor" EXACT []
xref: EC:1.2.4
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0016625
name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:jl]
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulphur protein as acceptor" EXACT []
xref: EC:1.2.7
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0016626
name: obsolete oxidoreductase activity, acting on the aldehyde or oxo group of donors, other acceptors
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces an acceptor other than NAD, NADP, oxygen, an iron-sulfur protein, disulphide or a cytochrome." [GOC:jl]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "oxidoreductase activity, acting on the aldehyde or oxo group of donors, other acceptors" EXACT []
is_obsolete: true
consider: GO:0016903

[Term]
id: GO:0016627
name: oxidoreductase activity, acting on the CH-CH group of donors
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
comment: Note that enzymes of class EC:1.3.99.- should also be annotated to this term.
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on the CH-CH group of donors, other acceptors" NARROW []
xref: EC:1.3
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016628
name: oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]
subset: gosubset_prok
xref: EC:1.3.1
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0016629
name: 12-oxophytodienoate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 8-[(1R,2R)-3-oxo-2-{(Z)-pent-2-en-1-yl}cyclopentyl]octanoate + NADP(+) = (15Z)-12-oxophyto-10,15-dienoate + H(+) + NADPH." [EC:1.3.1.42, RHEA:21891]
synonym: "12-oxo-phytodienoate reductase activity" EXACT []
synonym: "12-oxo-phytodienoic acid reductase activity" EXACT [EC:1.3.1.42]
synonym: "8-[(1R,2R)-3-oxo-2-{(Z)-pent-2-enyl}cyclopentyl]octanoate:NADP+ 4-oxidoreductase activity" EXACT [EC:1.3.1.42]
xref: EC:1.3.1.42
xref: KEGG:R03401
xref: MetaCyc:12-OXOPHYTODIENOATE-REDUCTASE-RXN
xref: RHEA:21891
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0016630
name: protochlorophyllide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: chlorophyllide a + NADP+ = protochlorophyllide + NADPH + H+." [EC:1.3.1.33]
subset: gosubset_prok
synonym: "chlorophyllide-a:NADP+ 7,8-oxidoreductase activity" EXACT [EC:1.3.1.33]
synonym: "NADPH-protochlorophyllide oxidoreductase activity" EXACT [EC:1.3.1.33]
synonym: "NADPH-protochlorophyllide reductase activity" EXACT [EC:1.3.1.33]
synonym: "NADPH2-protochlorophyllide oxidoreductase activity" EXACT [EC:1.3.1.33]
synonym: "protochlorophyllide oxidoreductase activity" EXACT [EC:1.3.1.33]
synonym: "protochlorophyllide photooxidoreductase activity" EXACT [EC:1.3.1.33]
xref: EC:1.3.1.33
xref: MetaCyc:RXN1F-10
xref: RHEA:11135
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0016631
name: enoyl-[acyl-carrier-protein] reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + NAD(P)+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NAD(P)H + H+." [EC:1.3.1.9, GOC:rb]
subset: gosubset_prok
synonym: "acyl-ACP dehydrogenase activity" EXACT [EC:1.3.1.-]
synonym: "enoyl-[acyl-carrier protein] reductase activity" EXACT []
synonym: "enoyl-ACP reductase activity" EXACT []
synonym: "enoyl-acyl carrier protein reductase" EXACT []
xref: EC:1.3.1.-
xref: MetaCyc:1.3.1.10-RXN
xref: MetaCyc:1.3.1.39-RXN
xref: MetaCyc:RXN1G-2527
xref: MetaCyc:RXN1G-2544
xref: MetaCyc:RXN1G-3232
xref: MetaCyc:RXN1G-3256
xref: MetaCyc:RXN1G-3613
xref: MetaCyc:RXN1G-3641
xref: MetaCyc:RXN1G-3667
xref: MetaCyc:RXN1G-3993
xref: MetaCyc:RXN1G-4140
xref: MetaCyc:RXN1G-45
xref: Wikipedia:Enoyl-acyl_carrier_protein_reductase
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0016632
name: oxidoreductase activity, acting on the CH-CH group of donors, cytochrome as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a cytochrome." [GOC:jl]
xref: EC:1.3.2
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0016633
name: galactonolactone dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-galactono-1,4-lactone + 2 ferricytochrome c = L-ascorbate + 2 ferrocytochrome c." [EC:1.3.2.3]
synonym: "GLDase activity" EXACT [EC:1.3.2.3]
synonym: "GLDHase activity" EXACT [EC:1.3.2.3]
synonym: "L-galactono-1,4-lactone dehydrogenase activity" EXACT []
synonym: "L-galactono-1,4-lactone:ferricytochrome-c oxidoreductase activity" EXACT [EC:1.3.2.3]
synonym: "L-galactono-gamma-lactone dehydrogenase activity" EXACT [EC:1.3.2.3]
synonym: "L-galactono-gamma-lactone:ferricytochrome-c oxidoreductase activity" EXACT [EC:1.3.2.3]
synonym: "L-galactonolactone dehydrogenase activity" EXACT [EC:1.3.2.3]
xref: EC:1.3.2.3
xref: MetaCyc:GALACTONOLACTONE-DEHYDROGENASE-RXN
is_a: GO:0016632 ! oxidoreductase activity, acting on the CH-CH group of donors, cytochrome as acceptor

[Term]
id: GO:0016634
name: oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl]
subset: gosubset_prok
xref: EC:1.3.3
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0016635
name: oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a quinone or related compound." [GOC:jl]
subset: gosubset_prok
xref: EC:1.3.5
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0016636
name: oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:jl]
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on the CH-CH group of donors, iron-sulphur protein as acceptor" EXACT []
xref: EC:1.3.7
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0016637
name: obsolete oxidoreductase activity, acting on the CH-CH group of donors, other acceptors
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces an acceptor other than quinone or related compound, a cytochrome, an iron-sulfur protein, NAD, NADP or oxygen." [GOC:jl]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "oxidoreductase activity, acting on the CH-CH group of donors, other acceptors" EXACT []
is_obsolete: true
consider: GO:0016627

[Term]
id: GO:0016638
name: oxidoreductase activity, acting on the CH-NH2 group of donors
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
comment: Note that enzymes of class EC:1.4.99.- should also be annotated to this term.
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on the CH-NH2 group of donors, other acceptors" NARROW []
xref: EC:1.4
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016639
name: oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]
subset: gosubset_prok
xref: EC:1.4.1
is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors

[Term]
id: GO:0016640
name: oxidoreductase activity, acting on the CH-NH2 group of donors, cytochrome as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a cytochrome molecule." [GOC:ai]
xref: EC:1.4.2
is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors

[Term]
id: GO:0016641
name: oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai]
subset: gosubset_prok
xref: EC:1.4.3
is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors

[Term]
id: GO:0016642
name: oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a disulfide group." [GOC:ai]
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on the CH-NH2 group of donors, disulphide as acceptor" EXACT []
xref: EC:1.4.4
is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors

[Term]
id: GO:0016643
name: oxidoreductase activity, acting on the CH-NH2 group of donors, iron-sulfur protein as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:ai]
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on the CH-NH2 group of donors, iron-sulphur protein as acceptor" EXACT []
xref: EC:1.4.7
is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors

[Term]
id: GO:0016644
name: obsolete oxidoreductase activity, acting on the CH-NH2 group of donors, other acceptors
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an acceptor other than a cytochrome, disulfide, an iron-sulfur protein, NAD, NADP or oxygen." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "oxidoreductase activity, acting on the CH-NH2 group of donors, other acceptors" EXACT []
is_obsolete: true
consider: GO:0016638

[Term]
id: GO:0016645
name: oxidoreductase activity, acting on the CH-NH group of donors
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
comment: Note that enzymes of class EC:1.5.99.- should also be annotated to this term.
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on the CH-NH group of donors, other acceptors" NARROW []
xref: EC:1.5
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016646
name: oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]
subset: gosubset_prok
xref: EC:1.5.1
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0016647
name: oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl]
subset: gosubset_prok
xref: EC:1.5.3
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0016648
name: oxidoreductase activity, acting on the CH-NH group of donors, disulfide as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces disulfide." [GOC:jl]
synonym: "oxidoreductase activity, acting on the CH-NH group of donors, disulphide as acceptor" EXACT []
xref: EC:1.5.4
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0016649
name: oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces quinone or similar compound." [GOC:jl]
subset: gosubset_prok
xref: EC:1.5.5
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0016650
name: obsolete oxidoreductase activity, acting on the CH-NH group of donors, other acceptors
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces an acceptor other than quinone or similar compound, disulfide, NAD, NADP, oxygen or a flavin." [GOC:jl]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "oxidoreductase activity, acting on the CH-NH group of donors, other acceptors" EXACT []
is_obsolete: true
consider: GO:0016645

[Term]
id: GO:0016651
name: oxidoreductase activity, acting on NAD(P)H
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
comment: Note that enzymes of class EC:1.6.99.- should also be annotated to this term.
subset: gosubset_prok
synonym: "NAD(P)H dehydrogenase" NARROW []
synonym: "oxidoreductase activity, acting on NADH or NADPH" RELATED []
synonym: "oxidoreductase activity, acting on NADH or NADPH, other acceptor" NARROW []
xref: EC:1.6
xref: Reactome:REACT_101516 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA, Taeniopygia guttata"
xref: Reactome:REACT_108125 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA, Sus scrofa"
xref: Reactome:REACT_164 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA, Homo sapiens"
xref: Reactome:REACT_32648 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA, Mus musculus"
xref: Reactome:REACT_79787 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA, Rattus norvegicus"
xref: Reactome:REACT_81411 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA, Xenopus tropicalis"
xref: Reactome:REACT_87412 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA, Danio rerio"
xref: Reactome:REACT_87857 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA, Bos taurus"
xref: Reactome:REACT_87883 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA, Gallus gallus"
xref: Reactome:REACT_89599 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA, Caenorhabditis elegans"
xref: Reactome:REACT_94209 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA, Canis familiaris"
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016652
name: oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on NAD or NADPH, NAD or NADP as acceptor" RELATED []
xref: EC:1.6.1
is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H

[Term]
id: GO:0016653
name: oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a heme protein." [GOC:ai]
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on NADH or NADPH, haem protein as acceptor" EXACT []
synonym: "oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor" RELATED []
xref: EC:1.6.2
is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H

[Term]
id: GO:0016655
name: oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule." [GOC:ai]
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor" RELATED []
xref: EC:1.6.5
is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H

[Term]
id: GO:0016656
name: monodehydroascorbate reductase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: NADH + H+ + 2 monodehydroascorbate = NAD+ + 2 ascorbate." [EC:1.6.5.4]
synonym: "AFR" RELATED [EC:1.6.5.4]
synonym: "AFR-reductase activity" EXACT [EC:1.6.5.4]
synonym: "ascorbate free radical reductase activity" EXACT [EC:1.6.5.4]
synonym: "ascorbate free-radical reductase activity" EXACT [EC:1.6.5.4]
synonym: "ascorbic free radical reductase activity" EXACT [EC:1.6.5.4]
synonym: "MDAsA reductase (NADPH)" EXACT [EC:1.6.5.4]
synonym: "MDHA" RELATED [EC:1.6.5.4]
synonym: "monodehydroascorbate reductase activity" EXACT []
synonym: "NADH-semidehydroascorbate oxidoreductase activity" EXACT [EC:1.6.5.4]
synonym: "NADH:AFR oxidoreductase activity" EXACT [EC:1.6.5.4]
synonym: "NADH:ascorbate radical oxidoreductase activity" EXACT [EC:1.6.5.4]
synonym: "NADH:monodehydroascorbate oxidoreductase activity" EXACT [EC:1.6.5.4]
synonym: "NADH:semidehydroascorbic acid oxidoreductase activity" EXACT [EC:1.6.5.4]
synonym: "SDA reductase activity" EXACT [EC:1.6.5.4]
synonym: "semidehydroascorbate reductase activity" EXACT [EC:1.6.5.4]
xref: EC:1.6.5.4
xref: MetaCyc:1.6.5.4-RXN
xref: RHEA:14584
is_a: GO:0016655 ! oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor

[Term]
id: GO:0016657
name: oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a nitrogenous group." [GOC:ai]
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor" RELATED []
xref: EC:1.6.6
is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H

[Term]
id: GO:0016658
name: obsolete oxidoreductase activity, acting on NADH or NADPH, flavin as acceptor
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it was a grouping term taken from EC that no longer has any functions associated with it.
synonym: "oxidoreductase activity, acting on NADH or NADPH, flavin as acceptor" EXACT []
is_obsolete: true
consider: GO:0008752
consider: GO:0042602

[Term]
id: GO:0016659
name: obsolete oxidoreductase activity, acting on NADH or NADPH, other acceptor
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an acceptor other than disulfide, a heme protein, NAD, NADP, a nitrogenous group, a quinone or similar compound or oxygen." [GOC:jl]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "oxidoreductase activity, acting on NADH or NADPH, other acceptor" EXACT []
is_obsolete: true
consider: GO:0016651

[Term]
id: GO:0016661
name: oxidoreductase activity, acting on other nitrogenous compounds as donors
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
comment: Note that enzymes of class EC:1.7.99.- should also be annotated to this term.
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on other nitrogenous compounds as donors, other acceptors" NARROW []
xref: EC:1.7
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016662
name: oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a cytochrome." [GOC:jl]
subset: gosubset_prok
xref: EC:1.7.2
is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors

[Term]
id: GO:0016663
name: oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl]
subset: gosubset_prok
xref: EC:1.7.3
is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors

[Term]
id: GO:0016664
name: oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulfur protein as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:jl]
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulphur protein as acceptor" EXACT []
xref: EC:1.7.7
is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors

[Term]
id: GO:0016665
name: obsolete oxidoreductase activity, acting on other nitrogenous compounds as donors, other acceptors
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces an acceptor other than a cytochrome, an iron-sulfur protein, oxygen, NAD or NADP." [GOC:jl]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "oxidoreductase activity, acting on other nitrogenous compounds as donors, other acceptors" EXACT []
is_obsolete: true
consider: GO:0016661

[Term]
id: GO:0016667
name: oxidoreductase activity, acting on a sulfur group of donors
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
comment: Note that enzymes of class EC:1.8.99.- should also be annotated to this term.
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on sulfur group of donors, other acceptors" NARROW []
synonym: "oxidoreductase activity, acting on sulphur group of donors" EXACT []
xref: EC:1.8
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016668
name: oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
namespace: molecular_function
alt_id: GO:0016654
def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on a sulfur group of donors, NAD or NADP as acceptor" RELATED []
synonym: "oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor" EXACT []
synonym: "oxidoreductase activity, acting on NADH or NADPH, disulphide as acceptor" EXACT []
synonym: "oxidoreductase activity, acting on sulphur group of donors, NAD or NADP as acceptor" EXACT []
xref: EC:1.8.1
is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H
is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors

[Term]
id: GO:0016669
name: oxidoreductase activity, acting on a sulfur group of donors, cytochrome as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a cytochrome." [GOC:jl]
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on sulphur group of donors, cytochrome as acceptor" EXACT []
xref: EC:1.8.2
is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors

[Term]
id: GO:0016670
name: oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl]
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on sulphur group of donors, oxygen as acceptor" EXACT []
xref: EC:1.8.3
is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors

[Term]
id: GO:0016671
name: oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide." [GOC:jl]
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on sulphur group of donors, disulphide as acceptor" EXACT []
xref: EC:1.8.4
is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors

[Term]
id: GO:0016672
name: oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces quinone or a related compound." [GOC:jl]
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on sulphur group of donors, quinone or similar compound as acceptor" EXACT []
xref: EC:1.8.5
is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors

[Term]
id: GO:0016673
name: oxidoreductase activity, acting on a sulfur group of donors, iron-sulfur protein as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:jl]
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on sulphur group of donors, iron-sulphur protein as acceptor" EXACT []
xref: EC:1.8.7
is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors

[Term]
id: GO:0016674
name: obsolete oxidoreductase activity, acting on sulfur group of donors, other acceptors
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces an acceptor other than quinone or a related compound, oxygen, NAD, NADP, an iron-sulfur protein, disulfide or a cytochrome." [GOC:jl]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "oxidoreductase activity, acting on sulfur group of donors, other acceptors" EXACT []
synonym: "oxidoreductase activity, acting on sulphur group of donors, other acceptors" EXACT []
is_obsolete: true
consider: GO:0016667

[Term]
id: GO:0016675
name: oxidoreductase activity, acting on a heme group of donors
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
comment: Note that enzymes of class EC:1.9.99.- should also be annotated to this term.
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on haem group of donors" EXACT []
synonym: "oxidoreductase activity, acting on heme group of donors, other acceptors" NARROW []
xref: EC:1.9
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016676
name: oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl]
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on haem group of donors, oxygen as acceptor" EXACT []
xref: EC:1.9.3
is_a: GO:0016675 ! oxidoreductase activity, acting on a heme group of donors

[Term]
id: GO:0016677
name: oxidoreductase activity, acting on a heme group of donors, nitrogenous group as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces a nitrogenous group." [GOC:jl]
synonym: "oxidoreductase activity, acting on haem group of donors, nitrogenous group as acceptor" EXACT []
xref: EC:1.9.6
is_a: GO:0016675 ! oxidoreductase activity, acting on a heme group of donors

[Term]
id: GO:0016678
name: obsolete oxidoreductase activity, acting on heme group of donors, other acceptors
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces an acceptor other than a nitrogenous group or oxygen." [GOC:jl]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "oxidoreductase activity, acting on haem group of donors, other acceptors" EXACT []
synonym: "oxidoreductase activity, acting on heme group of donors, other acceptors" EXACT []
is_obsolete: true
consider: GO:0016675

[Term]
id: GO:0016679
name: oxidoreductase activity, acting on diphenols and related substances as donors
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
comment: Note that enzymes of class EC:1.10.99.- should also be annotated to this term.
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on diphenols and related substances as donors, other acceptors" NARROW []
xref: EC:1.10
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016680
name: oxidoreductase activity, acting on diphenols and related substances as donors, NAD or NADP as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]
xref: EC:1.10.1
is_a: GO:0016679 ! oxidoreductase activity, acting on diphenols and related substances as donors

[Term]
id: GO:0016681
name: oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces a cytochrome." [GOC:jl]
subset: gosubset_prok
xref: EC:1.10.2
is_a: GO:0016679 ! oxidoreductase activity, acting on diphenols and related substances as donors

[Term]
id: GO:0016682
name: oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl]
subset: gosubset_prok
synonym: "laccase activity" RELATED [GOC:jh]
xref: EC:1.10.3
is_a: GO:0016679 ! oxidoreductase activity, acting on diphenols and related substances as donors

[Term]
id: GO:0016683
name: obsolete oxidoreductase activity, acting on diphenols and related substances as donors, other acceptors
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces an acceptor other than a cytochrome, NAD, NADP or oxygen." [GOC:jl]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "oxidoreductase activity, acting on diphenols and related substances as donors, other acceptors" EXACT []
is_obsolete: true
consider: GO:0016679

[Term]
id: GO:0016684
name: oxidoreductase activity, acting on peroxide as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which the peroxide group acts as a hydrogen or electron acceptor." [GOC:ai]
subset: gosubset_prok
xref: EC:1.11
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016688
name: L-ascorbate peroxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-ascorbate + hydrogen peroxide = dehydroascorbate + 2 H2O." [EC:1.11.1.11]
synonym: "ascorbate peroxidase activity" EXACT [EC:1.11.1.11]
synonym: "ascorbic acid peroxidase activity" EXACT [EC:1.11.1.11]
synonym: "L-ascorbate:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.11]
synonym: "L-ascorbic acid peroxidase activity" EXACT [EC:1.11.1.11]
synonym: "L-ascorbic acid-specific peroxidase activity" EXACT [EC:1.11.1.11]
xref: EC:1.11.1.11
xref: MetaCyc:L-ASCORBATE-PEROXIDASE-RXN
is_a: GO:0004601 ! peroxidase activity

[Term]
id: GO:0016689
name: manganese peroxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 Mn2+ + 2 H+ + hydrogen peroxide = 2 Mn3+ + 2 H2O." [EC:1.11.1.13]
synonym: "Mn(II):hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.13]
synonym: "Mn-dependent (NADH-oxidizing) peroxidase activity" EXACT [EC:1.11.1.13]
synonym: "Mn-dependent peroxidase activity" EXACT [EC:1.11.1.13]
synonym: "peroxidase-M2" RELATED [EC:1.11.1.13]
xref: EC:1.11.1.13
xref: MetaCyc:MANGANESE-PEROXIDASE-RXN
xref: RHEA:22779
is_a: GO:0004601 ! peroxidase activity

[Term]
id: GO:0016690
name: diarylpropane peroxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3,4-dimethoxyphenyl)methanol + H2O2 = 3,4-dimethoxybenzaldehyde + 2 H2O." [EC:1.11.1.14]
synonym: "1,2-bis(3,4-dimethoxyphenyl)propane-1,3-diol:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.14]
synonym: "diarylpropane oxygenase activity" EXACT [EC:1.11.1.14]
synonym: "diarylpropane:oxygen,hydrogen-peroxide oxidoreductase (C-C-bond-cleaving)" EXACT [EC:1.11.1.14]
synonym: "lignin peroxidase activity" EXACT [EC:1.11.1.14]
synonym: "ligninase activity" EXACT [EC:1.11.1.14]
synonym: "ligninase I activity" NARROW [EC:1.11.1.14]
synonym: "LiP activity" NARROW [EC:1.11.1.14]
xref: EC:1.11.1.14
xref: MetaCyc:DIARYLPROPANE-PEROXIDASE-RXN
xref: RHEA:30274
is_a: GO:0004601 ! peroxidase activity

[Term]
id: GO:0016691
name: chloride peroxidase activity
namespace: molecular_function
alt_id: GO:0016955
alt_id: GO:0016956
alt_id: GO:0016957
alt_id: GO:0016958
def: "Catalysis of the reaction: 2 R-H + 2 chloride + hydrogen peroxide = 2 R-Cl + 2 H2O." [EC:1.11.1.10]
subset: gosubset_prok
synonym: "chloride:hydrogen-peroxide oxidoreductase" EXACT [EC:1.11.1.10]
synonym: "chloroperoxidase activity" EXACT [EC:1.11.1.10]
synonym: "cofactor-free chloroperoxidase activity" NARROW []
synonym: "flavin-haem chloroperoxidase activity" NARROW []
synonym: "flavin-heme chloroperoxidase activity" NARROW []
synonym: "haem chloroperoxidase activity" NARROW []
synonym: "heme chloroperoxidase activity" NARROW []
synonym: "vanadium chloroperoxidase activity" NARROW []
xref: EC:1.11.1.10
xref: MetaCyc:CHLORIDE-PEROXIDASE-RXN
is_a: GO:0004601 ! peroxidase activity

[Term]
id: GO:0016692
name: NADH peroxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O(2) + H(+) + NADH = 2 H(2)O + NAD(+)." [EC:1.11.1.1, RHEA:18512]
subset: gosubset_prok
synonym: "diphosphopyridine nucleotide peroxidase activity" EXACT [EC:1.11.1.1]
synonym: "DPNH peroxidase activity" EXACT [EC:1.11.1.1]
synonym: "NAD peroxidase activity" EXACT [EC:1.11.1.1]
synonym: "NADH-peroxidase activity" EXACT [EC:1.11.1.1]
synonym: "NADH:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.1]
synonym: "nicotinamide adenine dinucleotide peroxidase activity" EXACT [EC:1.11.1.1]
xref: EC:1.11.1.1
xref: KEGG:R00090
xref: MetaCyc:NADH-PEROXIDASE-RXN
xref: RHEA:18512
is_a: GO:0004601 ! peroxidase activity

[Term]
id: GO:0016694
name: obsolete bacterial catalase-peroxidase activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a bifunctional gene product.
synonym: "bacterial catalase-peroxidase activity" EXACT []
is_obsolete: true
consider: GO:0004096
consider: GO:0004601

[Term]
id: GO:0016695
name: oxidoreductase activity, acting on hydrogen as donor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor." [GOC:jl]
comment: Note that enzymes of class EC:1.12.99.- should also be annotated to this term.
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on hydrogen as donor, other acceptors" NARROW []
xref: EC:1.12
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016696
name: oxidoreductase activity, acting on hydrogen as donor, NAD or NADP as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces NAD or NADP." [GOC:jl]
subset: gosubset_prok
xref: EC:1.12.1
is_a: GO:0016695 ! oxidoreductase activity, acting on hydrogen as donor

[Term]
id: GO:0016697
name: oxidoreductase activity, acting on hydrogen as donor, cytochrome as acceptor
namespace: molecular_function
alt_id: GO:0016698
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces a cytochrome." [GOC:jl]
subset: gosubset_prok
xref: EC:1.12.2
is_a: GO:0016695 ! oxidoreductase activity, acting on hydrogen as donor

[Term]
id: GO:0016699
name: oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
namespace: molecular_function
alt_id: GO:0016736
alt_id: GO:0019110
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces an iron-sulfur protein." [GOC:jl]
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on hydrogen as donor, iron-sulphur protein as acceptor" EXACT []
xref: EC:1.12.7
is_a: GO:0016695 ! oxidoreductase activity, acting on hydrogen as donor
is_a: GO:0016730 ! oxidoreductase activity, acting on iron-sulfur proteins as donors

[Term]
id: GO:0016700
name: obsolete oxidoreductase activity, acting on hydrogen as donor, other acceptors
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which hydrogen is the electron donor and reduces an acceptor other than a cytochrome, an iron-sulfur protein, NAD, NADP or a quinone or similar compound." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "oxidoreductase activity, acting on hydrogen as donor, other acceptors" EXACT []
is_obsolete: true
consider: GO:0016695

[Term]
id: GO:0016701
name: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and molecular oxygen is incorporated into a donor." [GOC:mah]
comment: Note that enzymes of class EC:1.13.99.- should also be annotated to this term.
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, miscellaneous" NARROW []
synonym: "oxygenase" BROAD []
xref: EC:1.13
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016702
name: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor." [GOC:mah]
subset: gosubset_prok
xref: EC:1.13.11
is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
is_a: GO:0051213 ! dioxygenase activity

[Term]
id: GO:0016703
name: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and one oxygen atom is incorporated into a donor." [GOC:mah]
subset: gosubset_prok
xref: EC:1.13.12
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen

[Term]
id: GO:0016704
name: obsolete oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, miscellaneous
namespace: molecular_function
def: "OBSOLETE. A grouping term for oxidoreductases acting on single donors with incorporation of molecular oxygen that cannot be more accurated categorized." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, miscellaneous" EXACT []
is_obsolete: true
consider: GO:0016701

[Term]
id: GO:0016705
name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
comment: Note that enzymes of class EC:1.14.99.- should also be annotated to this term.
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, miscellaneous" NARROW []
xref: EC:1.14
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016706
name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
namespace: molecular_function
alt_id: GO:0010302
def: "Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]
subset: gosubset_prok
synonym: "2-oxoglutarate dioxygenase activity" EXACT []
synonym: "2-oxoglutarate-dependent dioxygenase activity" EXACT []
xref: EC:1.14.11
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
is_a: GO:0051213 ! dioxygenase activity

[Term]
id: GO:0016707
name: gibberellin 3-beta-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a gibberellin + 2-oxoglutarate + O2 = a 3-beta-hydroxy-gibberellin + succinate + CO2." [EC:1.14.11.15, GOC:kad]
synonym: "(gibberellin-20),2-oxoglutarate:oxygen oxidoreductase (3beta-hydroxylating)" NARROW [EC:1.14.11.15]
synonym: "(gibberrellin-20),2-oxoglutarate: oxygen oxidoreductase (3beta-hydroxylating)" NARROW [EC:1.14.11.15]
synonym: "gibberellin 3-beta-hydroxylase activity" EXACT [EC:1.14.11.15]
synonym: "gibberellin 3beta-dioxygenase activity" EXACT [EC:1.14.11.15]
synonym: "gibberellin 3beta-hydroxylase activity" EXACT [EC:1.14.11.15]
xref: EC:1.14.11.15
xref: MetaCyc:RXN1F-170
xref: RHEA:10107
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0016708
name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and two atoms of oxygen are incorporated into one donor." [GOC:mah]
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor" RELATED []
xref: EC:1.14.12
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
is_a: GO:0051213 ! dioxygenase activity

[Term]
id: GO:0016709
name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen" RELATED []
xref: EC:1.14.13
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0016710
name: trans-cinnamate 4-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-cinnamate + NADPH + H+ + O2 = 4-hydroxycinnamate + NADP+ + H2O." [EC:1.14.13.11]
synonym: "CA4H activity" NARROW [EC:1.14.13.11]
synonym: "cinnamate 4-hydroxylase activity" EXACT [EC:1.14.13.11]
synonym: "cinnamate 4-monooxygenase activity" EXACT [EC:1.14.13.11]
synonym: "cinnamate hydroxylase activity" EXACT [EC:1.14.13.11]
synonym: "cinnamic 4-hydroxylase activity" EXACT [EC:1.14.13.11]
synonym: "cinnamic acid 4-hydroxylase activity" EXACT [EC:1.14.13.11]
synonym: "cinnamic acid 4-monooxygenase activity" EXACT [EC:1.14.13.11]
synonym: "cinnamic acid p-hydroxylase activity" EXACT [EC:1.14.13.11]
synonym: "cytochrome P450 cinnamate 4-hydroxylase activity" EXACT [EC:1.14.13.11]
synonym: "hydroxylase, cinnamate 4-" EXACT [EC:1.14.13.11]
synonym: "oxygenase, cinnamate 4-mono-" EXACT [EC:1.14.13.11]
synonym: "t-cinnamic acid hydroxylase activity" EXACT [EC:1.14.13.11]
synonym: "trans-cinnamate 4-hydroxylase activity" EXACT [EC:1.14.13.11]
synonym: "trans-cinnamate,NADPH:oxygen oxidoreductase (4-hydroxylating)" EXACT [EC:1.14.13.11]
synonym: "trans-cinnamic acid 4-hydroxylase activity" EXACT [EC:1.14.13.11]
xref: EC:1.14.13.11
xref: MetaCyc:TRANS-CINNAMATE-4-MONOOXYGENASE-RXN
xref: RHEA:10611
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0016711
name: flavonoid 3'-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a flavonoid + NADPH + H+ + O2 = 3'-hydroxyflavonoid + NADP+ + H2O." [EC:1.14.13.21]
synonym: "flavonoid 3'-hydroxylase activity" EXACT [EC:1.14.13.21]
synonym: "flavonoid 3-hydroxylase (erroneous)" EXACT [EC:1.14.13.21]
synonym: "flavonoid 3-monooxygenase (erroneous)" EXACT [EC:1.14.13.21]
synonym: "flavonoid,NADPH:oxygen oxidoreductase (3'-hydroxylating)" EXACT [EC:1.14.13.21]
synonym: "NADPH:flavonoid-3'-hydroxylase activity" EXACT [EC:1.14.13.21]
xref: EC:1.14.13.21
xref: MetaCyc:FLAVONOID-3-MONOOXYGENASE-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0016712
name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
namespace: molecular_function
alt_id: GO:0008402
alt_id: GO:0050381
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]
subset: gosubset_prok
synonym: "aryl hydrocarbon hydroxylase activity" NARROW [EC:1.14.14.1]
synonym: "aryl-4-monooxygenase activity" NARROW [EC:1.14.14.1]
synonym: "cytochrome p450 activity" NARROW [EC:1.14.14.1]
synonym: "cytochrome P450 CYP19" NARROW []
synonym: "flavoprotein monooxygenase activity" EXACT [EC:1.14.14.1]
synonym: "flavoprotein-linked monooxygenase activity" EXACT [EC:1.14.14.1]
synonym: "microsomal monooxygenase activity" NARROW [EC:1.14.14.1]
synonym: "microsomal P-450" RELATED [EC:1.14.14.1]
synonym: "microsomal p450 activity" NARROW [EC:1.14.14.1]
synonym: "substrate,reduced-flavoprotein:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)" EXACT [EC:1.14.14.1]
synonym: "unspecific monooxygenase activity" RELATED []
synonym: "xenobiotic monooxygenase activity" RELATED [EC:1.14.14.1]
xref: EC:1.14.14
xref: Reactome:REACT_13478 "CYP2D6 4-hydroxylates debrisoquine, Homo sapiens"
xref: Reactome:REACT_32302 "CYP2D6 4-hydroxylates debrisoquine, Xenopus tropicalis"
xref: Reactome:REACT_34782 "CYP2D6 4-hydroxylates debrisoquine, Rattus norvegicus"
xref: Reactome:REACT_77243 "CYP2D6 4-hydroxylates debrisoquine, Sus scrofa"
xref: Reactome:REACT_84785 "CYP2D6 4-hydroxylates debrisoquine, Mus musculus"
xref: Reactome:REACT_85000 "CYP2D6 4-hydroxylates debrisoquine, Taeniopygia guttata"
xref: Reactome:REACT_87747 "CYP2D6 4-hydroxylates debrisoquine, Canis familiaris"
xref: Reactome:REACT_88157 "CYP2D6 4-hydroxylates debrisoquine, Bos taurus"
xref: Reactome:REACT_93598 "CYP2D6 4-hydroxylates debrisoquine, Gallus gallus"
xref: UM-BBD_enzymeID:e0551
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0016713
name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced iron-sulfur protein and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulphur protein as one donor, and incorporation of one atom of oxygen" EXACT []
xref: EC:1.14.15
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0016714
name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced pteridine and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]
subset: gosubset_prok
xref: EC:1.14.16
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0016715
name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]
subset: gosubset_prok
xref: EC:1.14.17
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0016716
name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and one atom of oxygen is incorporated into one donor." [GOC:mah]
subset: gosubset_prok
xref: EC:1.14.18
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0016717
name: oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water." [GOC:mah]
subset: gosubset_prok
xref: EC:1.14.19
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0016718
name: obsolete oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, miscellaneous
namespace: molecular_function
def: "OBSOLETE. A grouping term for oxidoreductases, acting on paired donors with incorporation or reduction of molecular oxygen, that cannot be more accurately categorized." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, miscellaneous" EXACT []
is_obsolete: true
consider: GO:0016705

[Term]
id: GO:0016719
name: carotene 7,8-desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: neurosporene + donor-H2 + O2 = lycopene + acceptor + 2 H2O." [EC:1.14.99.30]
comment: This term represents a deleted EC activity and is scheduled for obsoletion.
subset: mf_needs_review
synonym: "carotene,hydrogen-donor:oxygen oxidoreductase activity" EXACT [EC:1.14.99.30]
synonym: "zeta-carotene desaturase activity" EXACT [EC:1.14.99.30]
xref: EC:1.14.99.30
xref: MetaCyc:1.14.99.30-RXN
xref: RHEA:15704
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0016720
name: delta12-fatty acid dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: AH(2) + linoleate + O(2) = A + crepenynate + 2 H(2)O." [EC:1.14.99.33, RHEA:23459]
synonym: "crepenynate synthase activity" NARROW [EC:1.14.99.33]
synonym: "D12-fatty acid dehydrogenase activity" EXACT []
synonym: "delta-12 fatty acid acetylenase activity" EXACT [EC:1.14.99.33]
synonym: "delta12 fatty acid acetylenase activity" EXACT [EC:1.14.99.33]
synonym: "linoleate delta-12-fatty acid acetylenase (desaturase) activity" EXACT []
synonym: "linoleate delta12-fatty acid acetylenase (desaturase)" EXACT [EC:1.14.99.33]
synonym: "linoleate, hydrogen-donor:oxygen oxidoreductase (Delta12-unsaturating)" EXACT [EC:1.14.99.33]
xref: EC:1.14.99.33
xref: KEGG:R05740
xref: MetaCyc:1.14.99.33-RXN
xref: RHEA:23459
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0016721
name: oxidoreductase activity, acting on superoxide radicals as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a superoxide radical (O2- or O2.-) acts as a hydrogen or electron acceptor." [GOC:ai]
subset: gosubset_prok
xref: EC:1.15
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016722
name: oxidoreductase activity, oxidizing metal ions
namespace: molecular_function
def: "Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered." [GOC:mah]
subset: gosubset_prok
xref: EC:1.16
xref: Reactome:REACT_25114 "Reduction of extracellular Fe3+, Homo sapiens"
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016723
name: oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered and NAD+ or NADP+ acts as an electron acceptor." [GOC:mah]
subset: gosubset_prok
xref: EC:1.16.1
xref: Reactome:REACT_24919 "Reduction of Fe3+ in the endosome, Homo sapiens"
is_a: GO:0016722 ! oxidoreductase activity, oxidizing metal ions

[Term]
id: GO:0016724
name: oxidoreductase activity, oxidizing metal ions, oxygen as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered and oxygen acts as an electron acceptor." [GOC:mah]
subset: gosubset_prok
xref: EC:1.16.3
is_a: GO:0016722 ! oxidoreductase activity, oxidizing metal ions

[Term]
id: GO:0016725
name: oxidoreductase activity, acting on CH or CH2 groups
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
comment: Note that enzymes of class EC:1.17.99.- should also be annotated to this term.
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on CH or CH2 groups, other acceptors" NARROW []
xref: EC:1.17
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016726
name: oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]
subset: gosubset_prok
xref: EC:1.17.1
is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups

[Term]
id: GO:0016727
name: oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai]
subset: gosubset_prok
xref: EC:1.17.3
is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups

[Term]
id: GO:0016728
name: oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a disulfide group." [GOC:ai]
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on CH or CH2 groups, disulphide as acceptor" EXACT []
xref: EC:1.17.4
is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups

[Term]
id: GO:0016729
name: obsolete oxidoreductase activity, acting on CH2 groups, other acceptors
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces an acceptor other than disulfide, NAD, NADP or oxygen." [GOC:jl]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "oxidoreductase activity, acting on CH2 groups, other acceptors" EXACT []
is_obsolete: true
consider: GO:0016725

[Term]
id: GO:0016730
name: oxidoreductase activity, acting on iron-sulfur proteins as donors
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on iron-sulphur proteins as donors" EXACT []
xref: EC:1.18
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016731
name: oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]
subset: gosubset_prok
xref: EC:1.18.1
is_a: GO:0016730 ! oxidoreductase activity, acting on iron-sulfur proteins as donors

[Term]
id: GO:0016732
name: oxidoreductase activity, acting on iron-sulfur proteins as donors, dinitrogen as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces dinitrogen." [GOC:jl]
subset: gosubset_prok
xref: EC:1.18.6
is_a: GO:0016730 ! oxidoreductase activity, acting on iron-sulfur proteins as donors

[Term]
id: GO:0016733
name: obsolete iron-iron nitrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 8 reduced ferredoxin + 8 H+ + N2 + 16 ATP = 8 oxidized ferredoxin + 2 NH3 + 16 ADP + 16 phosphate." [EC:1.18.6.1]
comment: This term was made obsolete because it represents a cellular component.
synonym: "iron-iron nitrogenase activity" EXACT []
is_obsolete: true
consider: GO:0016163
consider: GO:0016611

[Term]
id: GO:0016734
name: obsolete molybdenum-iron nitrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 8 reduced ferredoxin + 8 H+ + N2 + 16 ATP = 8 oxidized ferredoxin + 2 NH3 + 16 ADP + 16 phosphate." [EC:1.18.6.1]
comment: This term was made obsolete because it represents a cellular component.
synonym: "molybdenum-iron nitrogenase activity" EXACT []
is_obsolete: true
consider: GO:0016163
consider: GO:0016612

[Term]
id: GO:0016735
name: obsolete vanadium-iron nitrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 8 reduced ferredoxin + 8 H+ + nitrogen + 16 ATP = 8 oxidized ferredoxin + 2 NH3 + 16 ADP + 16 phosphate." [EC:1.18.6.1]
comment: This term was made obsolete because it represents a cellular component.
synonym: "vanadium-iron nitrogenase activity" EXACT []
is_obsolete: true
consider: GO:0016163
consider: GO:0016613

[Term]
id: GO:0016737
name: oxidoreductase activity, acting on reduced flavodoxin as donor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which reduced flavodoxin acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
subset: gosubset_prok
xref: EC:1.19
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016738
name: oxidoreductase activity, acting on reduced flavodoxin as donor, dinitrogen as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which reduced flavodoxin acts as a hydrogen or electron donor and reduces dinitrogen." [GOC:jl]
subset: gosubset_prok
xref: EC:1.19.6
is_a: GO:0016737 ! oxidoreductase activity, acting on reduced flavodoxin as donor

[Term]
id: GO:0016739
name: obsolete oxidoreductase activity, acting on other substrates
namespace: molecular_function
def: "OBSOLETE. A grouping term for oxidoreductase that cannot be more accurately categorized." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "oxidoreductase activity, acting on other substrates" EXACT []
is_obsolete: true
consider: GO:0016491

[Term]
id: GO:0016740
name: transferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
xref: EC:2
xref: Reactome:REACT_25050 "Molybdenum ion transfer onto molybdopterin, Homo sapiens"
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0016741
name: transferase activity, transferring one-carbon groups
namespace: molecular_function
def: "Catalysis of the transfer of a one-carbon group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
xref: EC:2.1
is_a: GO:0016740 ! transferase activity

[Term]
id: GO:0016742
name: hydroxymethyl-, formyl- and related transferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a hydroxymethyl- or formyl group from one compound (donor) to another (acceptor)." [EC:2.1.2, GOC:mah]
subset: gosubset_prok
xref: EC:2.1.2
is_a: GO:0016741 ! transferase activity, transferring one-carbon groups

[Term]
id: GO:0016743
name: carboxyl- or carbamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a carboxyl- or carbamoyl group from one compound (donor) to another (acceptor)." [GOC:jl]
subset: gosubset_prok
synonym: "carboxyl- and carbamoyltransferase activity" EXACT []
xref: EC:2.1.3
is_a: GO:0016741 ! transferase activity, transferring one-carbon groups

[Term]
id: GO:0016744
name: transferase activity, transferring aldehyde or ketonic groups
namespace: molecular_function
alt_id: GO:0016745
def: "Catalysis of the transfer of an aldehyde or ketonic group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "transketolase or transaldolase activity" EXACT []
xref: EC:2.2
xref: EC:2.2.1
is_a: GO:0016740 ! transferase activity

[Term]
id: GO:0016746
name: transferase activity, transferring acyl groups
namespace: molecular_function
alt_id: GO:0008415
def: "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: gosubset_prok
synonym: "acyltransferase activity" EXACT []
xref: EC:2.3
is_a: GO:0016740 ! transferase activity

[Term]
id: GO:0016747
name: transferase activity, transferring acyl groups other than amino-acyl groups
namespace: molecular_function
def: "Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]
subset: gosubset_prok
synonym: "transferase activity, transferring groups other than amino-acyl groups" EXACT [EC:2.3.1]
xref: EC:2.3.1
is_a: GO:0016746 ! transferase activity, transferring acyl groups

[Term]
id: GO:0016748
name: succinyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a succinyl (3-carboxypropanoyl) group to an acceptor molecule." [GOC:ai]
subset: gosubset_prok
xref: EC:2.3.1.-
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0016749
name: N-succinyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a succinyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]
subset: gosubset_prok
xref: EC:2.3.1.-
is_a: GO:0016410 ! N-acyltransferase activity
is_a: GO:0016748 ! succinyltransferase activity

[Term]
id: GO:0016750
name: O-succinyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a succinyl group to an oxygen atom on the acceptor molecule." [GOC:ai]
subset: gosubset_prok
xref: EC:2.3.1.-
is_a: GO:0008374 ! O-acyltransferase activity
is_a: GO:0016748 ! succinyltransferase activity

[Term]
id: GO:0016751
name: S-succinyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a succinyl group to a sulfur atom on the acceptor molecule." [GOC:ai]
subset: gosubset_prok
xref: EC:2.3.1.-
is_a: GO:0016417 ! S-acyltransferase activity
is_a: GO:0016748 ! succinyltransferase activity

[Term]
id: GO:0016752
name: sinapoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a sinapoyl group to an acceptor molecule." [GOC:ai]
xref: EC:2.3.1.-
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0016753
name: O-sinapoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a sinapoyl group to an oxygen atom on the acceptor molecule." [GOC:ai]
xref: EC:2.3.1.-
is_a: GO:0008374 ! O-acyltransferase activity
is_a: GO:0016752 ! sinapoyltransferase activity

[Term]
id: GO:0016754
name: sinapoylglucose-malate O-sinapoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-malate + 1-O-sinapoyl-beta-D-glucose = D-glucose + sinapoyl (S)-malate." [EC:2.3.1.92, RHEA:12628]
synonym: "1-O-sinapoyl-beta-D-glucose:(S)-malate O-sinapoyltransferase activity" EXACT [EC:2.3.1.92]
synonym: "1-sinapoylglucose-L-malate sinapoyltransferase activity" EXACT [EC:2.3.1.92]
synonym: "sinapoylglucose:malate sinapoyltransferase activity" EXACT []
xref: EC:2.3.1.92
xref: KEGG:R03323
xref: MetaCyc:2.3.1.92-RXN
xref: RHEA:12628
is_a: GO:0016753 ! O-sinapoyltransferase activity

[Term]
id: GO:0016755
name: transferase activity, transferring amino-acyl groups
namespace: molecular_function
def: "Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor)." [GOC:jl]
subset: gosubset_prok
synonym: "aminoacyltransferase activity" EXACT []
xref: EC:2.3.2
is_a: GO:0016746 ! transferase activity, transferring acyl groups

[Term]
id: GO:0016756
name: glutathione gamma-glutamylcysteinyltransferase activity
namespace: molecular_function
alt_id: GO:0042143
def: "Catalysis of the reaction: glutathione + Glu(-Cys)(n)-Gly = Gly + Glu(-Cys)(n+1)-Gly." [EC:2.3.2.15]
synonym: "gamma-glutamylcysteine dipeptidyl transpeptidase activity" EXACT [EC:2.3.2.15]
synonym: "glutathione:poly(4-glutamyl-cysteinyl)glycine 4-glutamylcysteinyltransferase activity" EXACT [EC:2.3.2.15]
synonym: "phytochelatin synthase activity" EXACT [EC:2.3.2.15]
xref: EC:2.3.2.15
xref: MetaCyc:2.3.2.15-RXN
is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups

[Term]
id: GO:0016757
name: transferase activity, transferring glycosyl groups
namespace: molecular_function
alt_id: GO:0016932
def: "Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
comment: Note that enzymes of class EC:2.4.99.- should also be annotated to this term.
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_yeast
subset: gosubset_prok
synonym: "glycosyltransferase activity" EXACT []
synonym: "transferase activity, transferring other glycosyl groups" NARROW []
synonym: "transglycosidase activity" EXACT []
synonym: "transglycosylase activity" EXACT []
xref: EC:2.4
is_a: GO:0016740 ! transferase activity

[Term]
id: GO:0016758
name: transferase activity, transferring hexosyl groups
namespace: molecular_function
def: "Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]
subset: gosubset_prok
synonym: "hexosyltransferase activity" EXACT []
xref: EC:2.4.1
is_a: GO:0016757 ! transferase activity, transferring glycosyl groups

[Term]
id: GO:0016759
name: cellulose synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside-disphosphate-glucose + ((1,4)-beta-D-glucosyl)(n) = nucleoside-disphosphate + ((1,4)-beta-D-glucosyl)(n+1)." [EC:2.4.1.12, EC:2.4.1.29]
subset: gosubset_prok
synonym: "cellulose synthetase activity" EXACT [EC:2.4.1.29]
xref: EC:2.4.1.-
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0016760
name: cellulose synthase (UDP-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + ((1,4)-beta-D-glucosyl)(n) = UDP + ((1,4)-beta-D-glucosyl)(n+1)." [EC:2.4.1.12]
subset: gosubset_prok
synonym: "1,4-beta-D-glucan synthase activity" EXACT [EC:2.4.1.12]
synonym: "1,4-beta-glucan synthase activity" EXACT [EC:2.4.1.12]
synonym: "beta-1,4-glucan synthase activity" EXACT [EC:2.4.1.12]
synonym: "beta-1,4-glucan synthetase activity" EXACT [EC:2.4.1.12]
synonym: "beta-1,4-glucosyltransferase activity" EXACT [EC:2.4.1.12]
synonym: "beta-glucan synthase activity" EXACT [EC:2.4.1.12]
synonym: "glucan synthase activity" EXACT [EC:2.4.1.12]
synonym: "GS-I" RELATED [EC:2.4.1.12]
synonym: "UDP-glucose-1,4-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.12]
synonym: "UDP-glucose-beta-D-glucan glucosyltransferase activity" EXACT [EC:2.4.1.12]
synonym: "UDP-glucose-cellulose glucosyltransferase activity" EXACT [EC:2.4.1.12]
synonym: "UDP-glucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.12]
synonym: "UDPglucose-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.12]
synonym: "UDPglucose-cellulose glucosyltransferase activity" EXACT [EC:2.4.1.12]
synonym: "UDPglucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.12]
synonym: "uridine diphosphoglucose-1,4-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.12]
synonym: "uridine diphosphoglucose-cellulose glucosyltransferase activity" EXACT [EC:2.4.1.12]
xref: EC:2.4.1.12
xref: MetaCyc:CELLULOSE-SYNTHASE-UDP-FORMING-RXN
is_a: GO:0016759 ! cellulose synthase activity
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0016761
name: cellulose synthase (GDP-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-glucose + ((1,4)-beta-D-glucosyl)(n) = GDP + ((1,4)-beta-D-glucosyl)(n+1)." [EC:2.4.1.29]
synonym: "cellulose synthase (guanosine diphosphate-forming) activity" EXACT [EC:2.4.1.29]
synonym: "GDP-glucose-beta-D-glucan glucosyltransferase activity" EXACT [EC:2.4.1.29]
synonym: "GDP-glucose-cellulose glucosyltransferase activity" EXACT [EC:2.4.1.29]
synonym: "GDP-glucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.29]
synonym: "GDPglucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.29]
synonym: "guanosine diphosphoglucose-1,4-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.29]
synonym: "guanosine diphosphoglucose-cellulose glucosyltransferase activity" EXACT [EC:2.4.1.29]
xref: EC:2.4.1.29
xref: MetaCyc:CELLULOSE-SYNTHASE-GDP-FORMING-RXN
is_a: GO:0016759 ! cellulose synthase activity

[Term]
id: GO:0016762
name: xyloglucan:xyloglucosyl transferase activity
namespace: molecular_function
def: "Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan." [EC:2.4.1.207]
synonym: "endo-xyloglucan transferase activity" EXACT [EC:2.4.1.207]
synonym: "endoxyloglucan transferase activity" EXACT []
synonym: "xyloglucan endotransglycosylase activity" EXACT [EC:2.4.1.207]
synonym: "xyloglucan:xyloglucan xyloglucanotransferase activity" EXACT [EC:2.4.1.207]
xref: EC:2.4.1.207
xref: MetaCyc:2.4.1.207-RXN
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0016763
name: transferase activity, transferring pentosyl groups
namespace: molecular_function
def: "Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor)." [GOC:jl]
subset: gosubset_prok
synonym: "pentosyltransferase activity" EXACT []
xref: EC:2.4.2
xref: Reactome:REACT_101331 "thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP], Mycobacterium tuberculosis"
xref: Reactome:REACT_106292 "thymidine or deoxyuridine + orthophosphate <=> thymine or uracil + 2-deoxy-D-ribose 1-phosphate [TYMP], Mus musculus"
xref: Reactome:REACT_107501 "thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP], Escherichia coli"
xref: Reactome:REACT_110489 "thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP], Rattus norvegicus"
xref: Reactome:REACT_2153 "thymidine or deoxyuridine + orthophosphate <=> thymine or uracil + 2-deoxy-D-ribose 1-phosphate [TYMP], Homo sapiens"
xref: Reactome:REACT_33257 "thymidine or deoxyuridine + orthophosphate <=> thymine or uracil + 2-deoxy-D-ribose 1-phosphate [TYMP], Xenopus tropicalis"
xref: Reactome:REACT_79932 "thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP], Staphylococcus aureus N315"
xref: Reactome:REACT_80603 "thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP], Xenopus tropicalis"
xref: Reactome:REACT_81285 "thymidine or deoxyuridine + orthophosphate <=> thymine or uracil + 2-deoxy-D-ribose 1-phosphate [TYMP], Staphylococcus aureus N315"
xref: Reactome:REACT_85341 "thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP], Mus musculus"
xref: Reactome:REACT_89279 "thymidine or deoxyuridine + orthophosphate <=> thymine or uracil + 2-deoxy-D-ribose 1-phosphate [TYMP], Mycobacterium tuberculosis"
xref: Reactome:REACT_95628 "thymidine or deoxyuridine + orthophosphate <=> thymine or uracil + 2-deoxy-D-ribose 1-phosphate [TYMP], Rattus norvegicus"
xref: Reactome:REACT_966 "thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP], Homo sapiens"
xref: Reactome:REACT_97046 "thymidine or deoxyuridine + orthophosphate <=> thymine or uracil + 2-deoxy-D-ribose 1-phosphate [TYMP], Escherichia coli"
is_a: GO:0016757 ! transferase activity, transferring glycosyl groups

[Term]
id: GO:0016764
name: obsolete transferase activity, transferring other glycosyl groups
namespace: molecular_function
def: "OBSOLETE. Catalysis of the transfer of a glycosyl group, other than hexosyl or pentosyl, from one compound (donor) to another (acceptor)." [GOC:jl]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "transferase activity, transferring other glycosyl groups" EXACT []
is_obsolete: true
consider: GO:0016757

[Term]
id: GO:0016765
name: transferase activity, transferring alkyl or aryl (other than methyl) groups
namespace: molecular_function
alt_id: GO:0016766
def: "Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: gosubset_prok
synonym: "transferase activity, transferring alkyl or aryl groups, other than methyl groups" EXACT []
xref: EC:2.5
xref: EC:2.5.1
is_a: GO:0016740 ! transferase activity

[Term]
id: GO:0016767
name: geranylgeranyl-diphosphate geranylgeranyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 geranylgeranyl diphosphate = diphosphate + prephytoene diphosphate." [EC:2.5.1.32]
subset: gosubset_prok
synonym: "geranylgeranyl-diphosphate:geranylgeranyl-diphosphate geranylgeranyltransferase activity" EXACT [EC:2.5.1.32]
synonym: "phytoene synthetase activity" EXACT [EC:2.5.1.32]
synonym: "prephytoene-diphosphate synthase activity" EXACT [EC:2.5.1.32]
synonym: "PSase activity" EXACT [EC:2.5.1.32]
xref: EC:2.5.1.32
xref: MetaCyc:2.5.1.32-RXN
xref: RHEA:22299
is_a: GO:0004337 ! geranyltranstransferase activity

[Term]
id: GO:0016768
name: spermine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosylmethioninamine + spermidine = 5'-methylthioadenosine + spermine." [EC:2.5.1.22]
synonym: "S-adenosylmethioninamine:spermidine 3-aminopropyltransferase activity" EXACT [EC:2.5.1.22]
synonym: "spermidine aminopropyltransferase activity" EXACT [EC:2.5.1.22]
synonym: "spermine synthetase activity" EXACT [EC:2.5.1.22]
xref: EC:2.5.1.22
xref: MetaCyc:SPERMINE-SYNTHASE-RXN
xref: Reactome:REACT_103119 "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine, Bos taurus"
xref: Reactome:REACT_105174 "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine, Taeniopygia guttata"
xref: Reactome:REACT_105595 "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine, Xenopus tropicalis"
xref: Reactome:REACT_112099 "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine, Oryza sativa"
xref: Reactome:REACT_113566 "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine, Mycobacterium tuberculosis"
xref: Reactome:REACT_114841 "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine, Arabidopsis thaliana"
xref: Reactome:REACT_14825 "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine, Homo sapiens"
xref: Reactome:REACT_34511 "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine, Mus musculus"
xref: Reactome:REACT_83790 "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine, Sus scrofa"
xref: Reactome:REACT_86585 "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine, Danio rerio"
xref: Reactome:REACT_88669 "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine, Canis familiaris"
xref: Reactome:REACT_95922 "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine, Gallus gallus"
xref: Reactome:REACT_97036 "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine, Drosophila melanogaster"
xref: RHEA:19976
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0016769
name: transferase activity, transferring nitrogenous groups
namespace: molecular_function
def: "Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
comment: Note that enzymes of class EC:2.6.99.- should also be annotated to this term.
subset: gosubset_prok
synonym: "transferase activity, transferring other nitrogenous groups" NARROW []
xref: EC:2.6
is_a: GO:0016740 ! transferase activity

[Term]
id: GO:0016770
name: oximinotransaminase activity
namespace: molecular_function
def: "Catalysis of the reversible transfer of an oxime group to an acceptor." [GOC:ai]
xref: EC:2.6.3
is_a: GO:0016769 ! transferase activity, transferring nitrogenous groups

[Term]
id: GO:0016771
name: obsolete transferase activity, transferring other nitrogenous groups
namespace: molecular_function
def: "OBSOLETE. Catalysis of the transfer of a nitrogenous group, other than amino, amidino or oxime, from one compound (donor) to another (acceptor)." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "transferase activity, transferring other nitrogenous groups" EXACT []
is_obsolete: true
consider: GO:0016769

[Term]
id: GO:0016772
name: transferase activity, transferring phosphorus-containing groups
namespace: molecular_function
def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
comment: Note that this term encompasses all kinase activities, as well as activities that transfer other phosphorus-containing groups such as diphosphate or nucleotides.
subset: goslim_chembl
subset: gosubset_prok
xref: EC:2.7
is_a: GO:0016740 ! transferase activity

[Term]
id: GO:0016773
name: phosphotransferase activity, alcohol group as acceptor
namespace: molecular_function
def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]
subset: gosubset_prok
xref: EC:2.7.1
is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups

[Term]
id: GO:0016774
name: phosphotransferase activity, carboxyl group as acceptor
namespace: molecular_function
def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a carboxyl group (acceptor)." [GOC:jl]
subset: gosubset_prok
xref: EC:2.7.2
is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups

[Term]
id: GO:0016775
name: phosphotransferase activity, nitrogenous group as acceptor
namespace: molecular_function
def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a nitrogenous group (acceptor)." [GOC:jl]
subset: gosubset_prok
xref: EC:2.7.3
is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups

[Term]
id: GO:0016776
name: phosphotransferase activity, phosphate group as acceptor
namespace: molecular_function
def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor)." [GOC:jl]
subset: gosubset_prok
xref: EC:2.7.4
is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups

[Term]
id: GO:0016778
name: diphosphotransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a diphosphate group from one compound (donor) to a another (acceptor)." [GOC:jl, http://www.chem.qmul.ac.uk/iubmb/enzyme/EC2/intro.html]
subset: gosubset_prok
xref: EC:2.7.6
is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups

[Term]
id: GO:0016779
name: nucleotidyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732]
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_yeast
subset: gosubset_prok
xref: EC:2.7.7
is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups

[Term]
id: GO:0016780
name: phosphotransferase activity, for other substituted phosphate groups
namespace: molecular_function
def: "Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor)." [GOC:jl, http://www.chem.qmul.ac.uk/iubmb/enzyme/EC2/intro.html]
subset: gosubset_prok
xref: EC:2.7.8
xref: Reactome:REACT_100707 "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI, Dictyostelium discoideum"
xref: Reactome:REACT_100805 "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI, Mus musculus"
xref: Reactome:REACT_101325 "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol, Caenorhabditis elegans"
xref: Reactome:REACT_102194 "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI, Taeniopygia guttata"
xref: Reactome:REACT_102635 "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI, Arabidopsis thaliana"
xref: Reactome:REACT_103177 "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI, Danio rerio"
xref: Reactome:REACT_103738 "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (acyl-GPI) + diacylglycerol, Rattus norvegicus"
xref: Reactome:REACT_104119 "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol, Dictyostelium discoideum"
xref: Reactome:REACT_104945 "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (acyl-GPI) + diacylglycerol, Gallus gallus"
xref: Reactome:REACT_105069 "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol, Gallus gallus"
xref: Reactome:REACT_105152 "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI, Xenopus tropicalis"
xref: Reactome:REACT_105178 "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol, Rattus norvegicus"
xref: Reactome:REACT_106366 "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol, Schizosaccharomyces pombe"
xref: Reactome:REACT_106435 "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol, Oryza sativa"
xref: Reactome:REACT_109665 "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol, Danio rerio"
xref: Reactome:REACT_110345 "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (acyl-GPI) + diacylglycerol, Bos taurus"
xref: Reactome:REACT_111955 "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol, Xenopus tropicalis"
xref: Reactome:REACT_113237 "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI, Saccharomyces cerevisiae"
xref: Reactome:REACT_113436 "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (acyl-GPI) + diacylglycerol, Saccharomyces cerevisiae"
xref: Reactome:REACT_114047 "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol, Drosophila melanogaster"
xref: Reactome:REACT_155 "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI, Homo sapiens"
xref: Reactome:REACT_1802 "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (acyl-GPI) + diacylglycerol, Mus musculus"
xref: Reactome:REACT_2043 "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (acyl-GPI) + diacylglycerol, Homo sapiens"
xref: Reactome:REACT_28634 "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (acyl-GPI) + diacylglycerol, Xenopus tropicalis"
xref: Reactome:REACT_28716 "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (acyl-GPI) + diacylglycerol, Drosophila melanogaster"
xref: Reactome:REACT_31213 "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI, Oryza sativa"
xref: Reactome:REACT_31672 "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI, Drosophila melanogaster"
xref: Reactome:REACT_32683 "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol, Sus scrofa"
xref: Reactome:REACT_32755 "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (acyl-GPI) + diacylglycerol, Canis familiaris"
xref: Reactome:REACT_464 "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol, Homo sapiens"
xref: Reactome:REACT_78148 "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI, Gallus gallus"
xref: Reactome:REACT_79457 "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI, Canis familiaris"
xref: Reactome:REACT_81401 "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (acyl-GPI) + diacylglycerol, Taeniopygia guttata"
xref: Reactome:REACT_82563 "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (acyl-GPI) + diacylglycerol, Danio rerio"
xref: Reactome:REACT_83736 "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol, Saccharomyces cerevisiae"
xref: Reactome:REACT_84128 "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (acyl-GPI) + diacylglycerol, Sus scrofa"
xref: Reactome:REACT_85210 "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI, Bos taurus"
xref: Reactome:REACT_85552 "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (acyl-GPI) + diacylglycerol, Arabidopsis thaliana"
xref: Reactome:REACT_85730 "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI, Rattus norvegicus"
xref: Reactome:REACT_88786 "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (acyl-GPI) + diacylglycerol, Oryza sativa"
xref: Reactome:REACT_89071 "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol, Taeniopygia guttata"
xref: Reactome:REACT_92140 "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol, Canis familiaris"
xref: Reactome:REACT_94510 "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol, Mus musculus"
xref: Reactome:REACT_98160 "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol, Bos taurus"
xref: Reactome:REACT_99847 "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol, Arabidopsis thaliana"
xref: Reactome:REACT_99956 "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (acyl-GPI) + diacylglycerol, Dictyostelium discoideum"
is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups

[Term]
id: GO:0016781
name: phosphotransferase activity, paired acceptors
namespace: molecular_function
def: "Catalysis of the transfer of two phosphate groups from a donor, such as ATP, to two different acceptors." [GOC:jl, http://www.chem.qmul.ac.uk/iubmb/enzyme/EC2/intro.html]
subset: gosubset_prok
xref: EC:2.7.9
is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups

[Term]
id: GO:0016782
name: transferase activity, transferring sulfur-containing groups
namespace: molecular_function
def: "Catalysis of the transfer of a sulfur-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "transferase activity, transferring sulphur-containing groups" EXACT []
xref: EC:2.8
xref: Reactome:REACT_27199 "sulfur transfer to carrier protein, Mycobacterium tuberculosis"
is_a: GO:0016740 ! transferase activity

[Term]
id: GO:0016783
name: sulfurtransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor)." [GOC:ai, ISBN:0721662544]
subset: gosubset_prok
synonym: "sulphurtransferase activity" EXACT []
synonym: "tRNA sulfurtransferase activity" NARROW [GOC:mah]
xref: EC:2.8.1
xref: Reactome:REACT_115702 "Persulfide sulfur is transferred onto sulfite, Homo sapiens"
xref: Reactome:REACT_25006 "Transfer of sulfur from MOCS3-S-S onto MOCS2A, Homo sapiens"
is_a: GO:0016782 ! transferase activity, transferring sulfur-containing groups

[Term]
id: GO:0016784
name: 3-mercaptopyruvate sulfurtransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-mercaptopyruvate + cyanide = pyruvate + thiocyanate." [EC:2.8.1.2]
subset: gosubset_prok
synonym: "3-mercaptopyruvate sulphurtransferase activity" EXACT []
synonym: "3-mercaptopyruvate:cyanide sulfurtransferase activity" EXACT [EC:2.8.1.2]
synonym: "beta-mercaptopyruvate sulfurtransferase activity" EXACT [EC:2.8.1.2]
synonym: "mercaptopyruvate sulfurtransferase activity" EXACT []
xref: EC:2.8.1.2
xref: MetaCyc:MERCAPYSTRANS-RXN
xref: RHEA:21743
is_a: GO:0016783 ! sulfurtransferase activity

[Term]
id: GO:0016785
name: transferase activity, transferring selenium-containing groups
namespace: molecular_function
alt_id: GO:0016786
def: "Catalysis of the transfer of a selenium-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "selenotransferase activity" EXACT []
xref: EC:2.9
xref: EC:2.9.1
is_a: GO:0016740 ! transferase activity

[Term]
id: GO:0016787
name: hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
xref: EC:3
xref: Reactome:REACT_110436 "Hydrolysis of phosphatidylcholine, Bos taurus"
xref: Reactome:REACT_111159 "Partial proteolysis of antigen in phagolysosomes, Homo sapiens"
xref: Reactome:REACT_15331 "Hydrolysis of phosphatidylcholine, Homo sapiens"
xref: Reactome:REACT_83734 "Hydrolysis of phosphatidylcholine, Danio rerio"
xref: Reactome:REACT_84047 "Hydrolysis of phosphatidylcholine, Xenopus tropicalis"
xref: Reactome:REACT_87959 "Hydrolysis of phosphatidylcholine, Gallus gallus"
xref: Reactome:REACT_88159 "Hydrolysis of phosphatidylcholine, Canis familiaris"
xref: Reactome:REACT_90118 "Hydrolysis of phosphatidylcholine, Mus musculus"
xref: Reactome:REACT_91045 "Hydrolysis of phosphatidylcholine, Taeniopygia guttata"
xref: Reactome:REACT_98572 "Hydrolysis of phosphatidylcholine, Rattus norvegicus"
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0016788
name: hydrolase activity, acting on ester bonds
namespace: molecular_function
def: "Catalysis of the hydrolysis of any ester bond." [GOC:jl]
subset: goslim_chembl
subset: goslim_metagenomics
subset: gosubset_prok
synonym: "esterase activity" EXACT []
xref: EC:3.1
xref: Reactome:REACT_106563 "Deacylation of Acyl Ghrelin, Mus musculus"
xref: Reactome:REACT_109748 "Deacylation of Acyl Ghrelin, Bos taurus"
xref: Reactome:REACT_112177 "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid, Xenopus tropicalis"
xref: Reactome:REACT_19294 "Deacylation of Acyl Ghrelin, Homo sapiens"
xref: Reactome:REACT_1978 "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid, Homo sapiens"
xref: Reactome:REACT_45174 "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid, Mus musculus"
xref: Reactome:REACT_77112 "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid, Danio rerio"
xref: Reactome:REACT_81282 "Deacylation of Acyl Ghrelin, Rattus norvegicus"
xref: Reactome:REACT_83347 "Deacylation of Acyl Ghrelin, Gallus gallus"
xref: Reactome:REACT_88228 "Deacylation of Acyl Ghrelin, Canis familiaris"
xref: Reactome:REACT_88314 "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid, Sus scrofa"
xref: Reactome:REACT_89615 "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid, Rattus norvegicus"
xref: Reactome:REACT_92446 "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid, Canis familiaris"
xref: Reactome:REACT_94475 "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid, Bos taurus"
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0016790
name: thiolester hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A." [http://www.onelook.com]
subset: gosubset_prok
synonym: "thiolesterase activity" EXACT []
xref: EC:3.1.2
is_a: GO:0016788 ! hydrolase activity, acting on ester bonds

[Term]
id: GO:0016791
name: phosphatase activity
namespace: molecular_function
alt_id: GO:0003869
alt_id: GO:0016302
def: "Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, EC:3.1.3.41, GOC:curators, GOC:pg]
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_yeast
subset: gosubset_prok
synonym: "4-nitrophenylphosphatase activity" NARROW []
synonym: "4-nitrophenylphosphate phosphohydrolase activity" NARROW [EC:3.1.3.41]
synonym: "ecto-p-nitrophenyl phosphatase activity" NARROW [EC:3.1.3.41]
synonym: "K-pNPPase activity" NARROW [EC:3.1.3.41]
synonym: "nitrophenyl phosphatase activity" NARROW [EC:3.1.3.41]
synonym: "NPPase activity" NARROW [EC:3.1.3.41]
synonym: "p-nitrophenylphosphatase activity" NARROW [EC:3.1.3.41]
synonym: "p-nitrophenylphosphate phosphohydrolase activity" NARROW [EC:3.1.3.41]
synonym: "para-nitrophenyl phosphatase activity" NARROW [EC:3.1.3.41]
synonym: "phosphatase" RELATED []
synonym: "phosphoric monoester hydrolase activity" EXACT []
synonym: "PNPPase activity" NARROW [EC:3.1.3.41]
xref: EC:3.1.3
xref: EC:3.1.3.41
xref: MetaCyc:4-NITROPHENYLPHOSPHATASE-RXN
xref: RHEA:21667
is_a: GO:0042578 ! phosphoric ester hydrolase activity
relationship: part_of GO:0016311 ! dephosphorylation

[Term]
id: GO:0016793
name: triphosphoric monoester hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a triphosphoester to give a triphosphate group and a free hydroxyl group." [GOC:ai]
subset: gosubset_prok
xref: EC:3.1.5
is_a: GO:0042578 ! phosphoric ester hydrolase activity

[Term]
id: GO:0016794
name: diphosphoric monoester hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a diphosphoester to give a diphosphate group and a free hydroxyl group." [GOC:ai]
subset: gosubset_prok
xref: EC:3.1.7
is_a: GO:0042578 ! phosphoric ester hydrolase activity

[Term]
id: GO:0016795
name: phosphoric triester hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a phosphoric triester." [EC:3.1.8, GOC:curators]
xref: EC:3.1.8
is_a: GO:0042578 ! phosphoric ester hydrolase activity

[Term]
id: GO:0016796
name: exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters." [GOC:mah]
comment: Note that this activity can catalyze cleavage of DNA or RNA.
subset: gosubset_prok
synonym: "exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5' phosphomonoesters" EXACT []
xref: EC:3.1.15
is_a: GO:0004527 ! exonuclease activity

[Term]
id: GO:0016797
name: exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end to yield 3' phosphomonoesters." [GOC:mah]
comment: Note that this activity can catalyze cleavage of DNA or RNA.
subset: gosubset_prok
xref: EC:3.1.16
is_a: GO:0004527 ! exonuclease activity

[Term]
id: GO:0016798
name: hydrolase activity, acting on glycosyl bonds
namespace: molecular_function
def: "Catalysis of the hydrolysis of any glycosyl bond." [GOC:jl]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_yeast
subset: gosubset_prok
synonym: "glycosidase activity" EXACT []
synonym: "glycosylase" NARROW []
synonym: "N-glycosylase" NARROW []
xref: EC:3.2
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0016799
name: hydrolase activity, hydrolyzing N-glycosyl compounds
namespace: molecular_function
def: "Catalysis of the hydrolysis of any N-glycosyl bond." [GOC:jl]
subset: gosubset_prok
xref: EC:3.2.2
is_a: GO:0016798 ! hydrolase activity, acting on glycosyl bonds

[Term]
id: GO:0016801
name: hydrolase activity, acting on ether bonds
namespace: molecular_function
def: "Catalysis of the hydrolysis of any ether or thioether bond, -O- or -S- respectively." [GOC:ai, GOC:jl]
subset: gosubset_prok
xref: EC:3.3
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0016802
name: trialkylsulfonium hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a thioether bond, -S-." [EC:3.3.1.-, GOC:ai]
subset: gosubset_prok
synonym: "thioether hydrolase activity" EXACT []
synonym: "trialkylsulphonium hydrolase activity" EXACT []
xref: EC:3.3.1.-
is_a: GO:0016801 ! hydrolase activity, acting on ether bonds

[Term]
id: GO:0016803
name: ether hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of an ether bond, -O-." [EC:3.3.2.-, GOC:ai]
subset: gosubset_prok
xref: EC:3.3.2
is_a: GO:0016801 ! hydrolase activity, acting on ether bonds

[Term]
id: GO:0016804
name: obsolete prolyl aminopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of a N-terminal proline from a peptide." [EC:3.4.11.5]
comment: This term was made obsolete because it represents a gene product, and the substrate specificity it refers to is not cleanly defined.
subset: gosubset_prok
synonym: "cytosol aminopeptidase V" RELATED [EC:3.4.11.5]
synonym: "Pro-X aminopeptidase activity" EXACT [EC:3.4.11.5]
synonym: "proline aminopeptidase" BROAD [EC:3.4.11.5]
synonym: "proline iminopeptidase activity" EXACT []
synonym: "prolyl aminopeptidase activity" EXACT []
xref: EC:3.4.11.5
xref: MetaCyc:3.4.11.5-RXN
is_obsolete: true
replaced_by: GO:0004177

[Term]
id: GO:0016805
name: dipeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a dipeptide." [http://www.onelook.com]
subset: gosubset_prok
xref: EC:3.4.13
xref: Reactome:REACT_105066 "Further cleavage of LTD4 forms LTE4, Xenopus tropicalis"
xref: Reactome:REACT_106751 "Further cleavage of LTD4 forms LTE4, Taeniopygia guttata"
xref: Reactome:REACT_106822 "Further cleavage of LTD4 forms LTE4, Schizosaccharomyces pombe"
xref: Reactome:REACT_15395 "Further cleavage of LTD4 forms LTE4, Homo sapiens"
xref: Reactome:REACT_79177 "Further cleavage of LTD4 forms LTE4, Bos taurus"
xref: Reactome:REACT_80958 "Further cleavage of LTD4 forms LTE4, Mus musculus"
xref: Reactome:REACT_83051 "Further cleavage of LTD4 forms LTE4, Danio rerio"
xref: Reactome:REACT_89727 "Further cleavage of LTD4 forms LTE4, Drosophila melanogaster"
xref: Reactome:REACT_92598 "Further cleavage of LTD4 forms LTE4, Canis familiaris"
xref: Reactome:REACT_93392 "Further cleavage of LTD4 forms LTE4, Rattus norvegicus"
xref: Reactome:REACT_96616 "Further cleavage of LTD4 forms LTE4, Gallus gallus"
is_a: GO:0008238 ! exopeptidase activity

[Term]
id: GO:0016806
name: obsolete dipeptidyl-peptidase and tripeptidyl-peptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of N-terminal di- or tripeptides from a polypeptide chain." [GOC:ai]
comment: This term was made obsolete because it represents two activities.
subset: gosubset_prok
synonym: "dipeptidyl-peptidase and tripeptidyl-peptidase activity" EXACT []
xref: EC:3.4.14
is_obsolete: true

[Term]
id: GO:0016807
name: cysteine-type carboxypeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of C-terminal peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
xref: EC:3.4.18
xref: MetaCyc:3.4.18.1-RXN
is_a: GO:0004180 ! carboxypeptidase activity
is_a: GO:0070004 ! cysteine-type exopeptidase activity

[Term]
id: GO:0016808
name: obsolete proprotein convertase activity
namespace: molecular_function
def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "proprotein convertase activity" EXACT []
xref: EC:3.4.21.-
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0016810
name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
namespace: molecular_function
def: "Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]
comment: Note that enzymes of class EC:3.5.99.- should also be annotated to this term.
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: gosubset_prok
synonym: "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in other compounds" NARROW []
xref: EC:3.5
xref: Reactome:REACT_27208 "acetylglucosamine-inositol is deacetylated by Mca, Mycobacterium tuberculosis"
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0016811
name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
namespace: molecular_function
def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai]
subset: gosubset_prok
xref: EC:3.5.1
xref: Reactome:REACT_27249 "mycothiol is cleaved to acetylcysteine and glucosaminylinositol, Mycobacterium tuberculosis"
xref: Reactome:REACT_27304 "mycothiol S-conjugate is cleaved into mercapturic acid and GlcN-Ins, Mycobacterium tuberculosis"
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

[Term]
id: GO:0016812
name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
namespace: molecular_function
def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amide." [GOC:ai]
subset: gosubset_prok
xref: EC:3.5.2
xref: Reactome:REACT_102715 "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+, Gallus gallus"
xref: Reactome:REACT_106976 "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+, Dictyostelium discoideum"
xref: Reactome:REACT_107522 "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+, Xenopus tropicalis"
xref: Reactome:REACT_108263 "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+, Staphylococcus aureus N315"
xref: Reactome:REACT_108704 "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+, Danio rerio"
xref: Reactome:REACT_109582 "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+, Taeniopygia guttata"
xref: Reactome:REACT_28130 "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+, Sus scrofa"
xref: Reactome:REACT_30978 "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+, Caenorhabditis elegans"
xref: Reactome:REACT_573 "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+, Homo sapiens"
xref: Reactome:REACT_79888 "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+, Mus musculus"
xref: Reactome:REACT_92464 "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+, Bos taurus"
xref: Reactome:REACT_96891 "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+, Rattus norvegicus"
xref: Reactome:REACT_98459 "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+, Canis familiaris"
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

[Term]
id: GO:0016813
name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
namespace: molecular_function
def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2." [ISBN:0198506732]
subset: gosubset_prok
xref: EC:3.5.3
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

[Term]
id: GO:0016814
name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
namespace: molecular_function
def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2." [ISBN:0198506732]
subset: gosubset_prok
xref: EC:3.5.4
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

[Term]
id: GO:0016815
name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles
namespace: molecular_function
def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a nitrile, a compound containing the cyano radical, -CN." [http://www.onelook.com/]
subset: gosubset_prok
xref: EC:3.5.5
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

[Term]
id: GO:0016816
name: obsolete hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in other compounds
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in substances other than amides, amidines and nitriles." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in other compounds" EXACT []
is_obsolete: true
consider: GO:0016810

[Term]
id: GO:0016817
name: hydrolase activity, acting on acid anhydrides
namespace: molecular_function
def: "Catalysis of the hydrolysis of any acid anhydride." [GOC:jl]
subset: gosubset_prok
synonym: "hydrolase activity, acting on acid anhydrides, involved in cellular and subcellular movement" NARROW []
xref: EC:3.6
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0016818
name: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
namespace: molecular_function
def: "Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl]
subset: gosubset_prok
xref: EC:3.6.1
is_a: GO:0016817 ! hydrolase activity, acting on acid anhydrides

[Term]
id: GO:0016819
name: hydrolase activity, acting on acid anhydrides, in sulfonyl-containing anhydrides
namespace: molecular_function
def: "Catalysis of the hydrolysis of any acid anhydride which contains a sulfonyl group, -SO2-." [GOC:ai]
synonym: "hydrolase activity, acting on acid anhydrides, in sulphonyl-containing anhydrides" EXACT []
xref: EC:3.6.2
is_a: GO:0016817 ! hydrolase activity, acting on acid anhydrides

[Term]
id: GO:0016820
name: hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
namespace: molecular_function
def: "Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane." [GOC:mah]
subset: gosubset_prok
xref: EC:3.6.3
is_a: GO:0016817 ! hydrolase activity, acting on acid anhydrides
is_a: GO:0022804 ! active transmembrane transporter activity

[Term]
id: GO:0016821
name: obsolete hydrolase activity, acting on acid anhydrides, involved in cellular and subcellular movement
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it incorporates process information.
synonym: "hydrolase activity, acting on acid anhydrides, involved in cellular and subcellular movement" EXACT []
is_obsolete: true
replaced_by: GO:0016817

[Term]
id: GO:0016822
name: hydrolase activity, acting on acid carbon-carbon bonds
namespace: molecular_function
def: "Catalysis of the hydrolysis of any acid carbon-carbon bond." [GOC:jl]
subset: gosubset_prok
xref: EC:3.7
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0016823
name: hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances
namespace: molecular_function
def: "Catalysis of the hydrolysis of any acid carbon-carbon bond in a ketonic substance, a substance containing a keto (C=O) group." [GOC:ai]
subset: gosubset_prok
xref: EC:3.7.1
is_a: GO:0016822 ! hydrolase activity, acting on acid carbon-carbon bonds

[Term]
id: GO:0016824
name: hydrolase activity, acting on acid halide bonds
namespace: molecular_function
def: "Catalysis of the hydrolysis of any acid halide bond." [GOC:jl]
subset: gosubset_prok
xref: EC:3.8
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0016825
name: hydrolase activity, acting on acid phosphorus-nitrogen bonds
namespace: molecular_function
def: "Catalysis of the hydrolysis of any acid phosphorus-nitrogen bond." [GOC:jl]
xref: EC:3.9
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0016826
name: hydrolase activity, acting on acid sulfur-nitrogen bonds
namespace: molecular_function
def: "Catalysis of the hydrolysis of any acid sulfur-nitrogen bond." [GOC:jl]
synonym: "hydrolase activity, acting on acid sulphur-nitrogen bonds" EXACT []
xref: EC:3.10
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0016827
name: hydrolase activity, acting on acid carbon-phosphorus bonds
namespace: molecular_function
def: "Catalysis of the hydrolysis of any acid carbon-phosphorus bond." [GOC:jl]
subset: gosubset_prok
xref: EC:3.11
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0016828
name: hydrolase activity, acting on acid sulfur-sulfur bonds
namespace: molecular_function
def: "Catalysis of the hydrolysis of any acid sulfur-sulfur bond." [GOC:jl]
synonym: "hydrolase activity, acting on acid sulphur-sulphur bonds" EXACT []
xref: EC:3.12
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0016829
name: lyase activity
namespace: molecular_function
def: "Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, ISBN:0198547684]
comment: Note that enzymes of class EC:4.99.-.- should also be annotated to this term.
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
synonym: "other lyase activity" NARROW []
xref: EC:4
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0016830
name: carbon-carbon lyase activity
namespace: molecular_function
def: "Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]
comment: Note that enzymes of class EC:4.1.99.- should also be annotated to this term.
subset: gosubset_prok
synonym: "other carbon-carbon lyase activity" NARROW []
xref: EC:4.1
xref: Reactome:REACT_101892 "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA, Oryza sativa"
xref: Reactome:REACT_105288 "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA, Rattus norvegicus"
xref: Reactome:REACT_109564 "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA, Xenopus tropicalis"
xref: Reactome:REACT_110987 "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA, Escherichia coli"
xref: Reactome:REACT_17035 "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA, Homo sapiens"
xref: Reactome:REACT_77552 "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA, Danio rerio"
xref: Reactome:REACT_79421 "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA, Saccharomyces cerevisiae"
xref: Reactome:REACT_81582 "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA, Mus musculus"
xref: Reactome:REACT_83933 "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA, Caenorhabditis elegans"
xref: Reactome:REACT_84590 "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA, Canis familiaris"
xref: Reactome:REACT_84946 "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA, Sus scrofa"
xref: Reactome:REACT_88741 "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA, Mycobacterium tuberculosis"
xref: Reactome:REACT_91444 "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA, Taeniopygia guttata"
xref: Reactome:REACT_91730 "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA, Arabidopsis thaliana"
xref: Reactome:REACT_91901 "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA, Dictyostelium discoideum"
xref: Reactome:REACT_95327 "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA, Schizosaccharomyces pombe"
xref: Reactome:REACT_95341 "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA, Drosophila melanogaster"
xref: Reactome:REACT_97863 "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA, Bos taurus"
xref: Reactome:REACT_98543 "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA, Gallus gallus"
is_a: GO:0016829 ! lyase activity

[Term]
id: GO:0016831
name: carboxy-lyase activity
namespace: molecular_function
def: "Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [http://www.mercksource.com/]
subset: gosubset_prok
synonym: "decarboxylase activity" EXACT []
xref: EC:4.1.1
xref: Reactome:REACT_106330 "2-amino-3-carboxymuconate semialdehyde => 2-aminomuconate semialdehyde + CO2, Staphylococcus aureus N315"
xref: Reactome:REACT_106753 "2-amino-3-carboxymuconate semialdehyde => 2-aminomuconate semialdehyde + CO2, Taeniopygia guttata"
xref: Reactome:REACT_107600 "2-amino-3-carboxymuconate semialdehyde => 2-aminomuconate semialdehyde + CO2, Sus scrofa"
xref: Reactome:REACT_107810 "2-amino-3-carboxymuconate semialdehyde => 2-aminomuconate semialdehyde + CO2, Dictyostelium discoideum"
xref: Reactome:REACT_108505 "2-amino-3-carboxymuconate semialdehyde => 2-aminomuconate semialdehyde + CO2, Danio rerio"
xref: Reactome:REACT_109521 "2-amino-3-carboxymuconate semialdehyde => 2-aminomuconate semialdehyde + CO2, Xenopus tropicalis"
xref: Reactome:REACT_1499 "2-amino-3-carboxymuconate semialdehyde => 2-aminomuconate semialdehyde + CO2 [rat], Rattus norvegicus"
xref: Reactome:REACT_30831 "2-amino-3-carboxymuconate semialdehyde => 2-aminomuconate semialdehyde + CO2, Bos taurus"
xref: Reactome:REACT_31585 "2-amino-3-carboxymuconate semialdehyde => 2-aminomuconate semialdehyde + CO2, Gallus gallus"
xref: Reactome:REACT_333 "2-amino-3-carboxymuconate semialdehyde => 2-aminomuconate semialdehyde + CO2, Homo sapiens"
xref: Reactome:REACT_77042 "2-amino-3-carboxymuconate semialdehyde => 2-aminomuconate semialdehyde + CO2, Caenorhabditis elegans"
xref: Reactome:REACT_79938 "2-amino-3-carboxymuconate semialdehyde => 2-aminomuconate semialdehyde + CO2, Canis familiaris"
xref: Reactome:REACT_97441 "2-amino-3-carboxymuconate semialdehyde => 2-aminomuconate semialdehyde + CO2, Mus musculus"
is_a: GO:0016830 ! carbon-carbon lyase activity

[Term]
id: GO:0016832
name: aldehyde-lyase activity
namespace: molecular_function
alt_id: GO:0016228
def: "Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone." [http://www.mercksource.com/]
subset: gosubset_prok
synonym: "aldolase activity" BROAD []
xref: EC:4.1.2
is_a: GO:0016830 ! carbon-carbon lyase activity

[Term]
id: GO:0016833
name: oxo-acid-lyase activity
namespace: molecular_function
def: "Catalysis of the cleavage of a C-C bond by other means than by hydrolysis or oxidation, of a 3-hydroxy acid." [EC:4.1.3, GOC:jl]
subset: gosubset_prok
synonym: "oxo-acid lyase activity" EXACT []
synonym: "oxoacid lyase activity" EXACT []
xref: EC:4.1.3
is_a: GO:0016830 ! carbon-carbon lyase activity

[Term]
id: GO:0016834
name: obsolete other carbon-carbon lyase activity
namespace: molecular_function
def: "OBSOLETE. A grouping term for carbon-carbon lyases that cannot be more accurately categorized." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "other carbon-carbon lyase activity" EXACT []
is_obsolete: true
consider: GO:0016830

[Term]
id: GO:0016835
name: carbon-oxygen lyase activity
namespace: molecular_function
def: "Catalysis of the breakage of a carbon-oxygen bond." [EC:4.2.-.-]
comment: Note that enzymes of class EC:4.2.99.- should also be annotated to this term.
subset: gosubset_prok
synonym: "other carbon-oxygen lyase activity" NARROW []
xref: EC:4.2
is_a: GO:0016829 ! lyase activity

[Term]
id: GO:0016836
name: hydro-lyase activity
namespace: molecular_function
def: "Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1]
subset: gosubset_prok
xref: EC:4.2.1
is_a: GO:0016835 ! carbon-oxygen lyase activity

[Term]
id: GO:0016837
name: carbon-oxygen lyase activity, acting on polysaccharides
namespace: molecular_function
def: "Catalysis of the cleavage of a carbon-oxygen bond by the elimination of an alcohol from a polysaccharide." [EC:4.2.-.-]
subset: gosubset_prok
xref: EC:4.2.2
is_a: GO:0016835 ! carbon-oxygen lyase activity

[Term]
id: GO:0016838
name: carbon-oxygen lyase activity, acting on phosphates
namespace: molecular_function
def: "Catalysis of the cleavage of a carbon-oxygen bond by elimination of a phosphate." [EC:4.2.-.-]
subset: gosubset_prok
xref: EC:4.2.3
is_a: GO:0016835 ! carbon-oxygen lyase activity

[Term]
id: GO:0016839
name: obsolete other carbon-oxygen lyase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of a carbon-oxygen bond. Enzymes with this activity are 'miscellaneous' carbon-oxygen lyases that cannot be grouped into one of the specific subclasses of the carbon-oxygen lyases." [GOC:krc]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "other carbon-oxygen lyase activity" EXACT []
is_obsolete: true
consider: GO:0016835

[Term]
id: GO:0016840
name: carbon-nitrogen lyase activity
namespace: molecular_function
def: "Catalysis of the release of ammonia or one of its derivatives, with the formation of a double bond or ring. Enzymes with this activity may catalyze the actual elimination of the ammonia, amine or amide, e.g. CH-CH(-NH-R) = C=CH- + NH2-R. Others, however, catalyze elimination of another component, e.g. water, which is followed by spontaneous reactions that lead to breakage of the C-N bond, e.g. L-serine ammonia-lyase (EC:4.3.1.17), so that the overall reaction is C(-OH)-CH(-NH2) = CH2-CO- + NH3, i.e. an elimination with rearrangement. The sub-subclasses of EC:4.3 are the ammonia-lyases (EC:4.3.1), lyases acting on amides, amidines, etc. (EC:4.3.2), the amine-lyases (EC:4.3.3), and other carbon-nitrogen lyases (EC:4.3.99)." [EC:4.3.-.-]
comment: Note that enzymes of class EC:4.3.99.- should also be annotated to this term.
subset: gosubset_prok
synonym: "other carbon-nitrogen lyase activity" NARROW []
xref: EC:4.3
is_a: GO:0016829 ! lyase activity

[Term]
id: GO:0016841
name: ammonia-lyase activity
namespace: molecular_function
def: "Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate." [EC:4.3.-.-, GOC:krc]
subset: gosubset_prok
xref: EC:4.3.1
is_a: GO:0016840 ! carbon-nitrogen lyase activity

[Term]
id: GO:0016842
name: amidine-lyase activity
namespace: molecular_function
def: "Catalysis of the release of amides or amidines by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amide or amidine as a substrate." [EC:4.3.-.-, GOC:krc]
subset: gosubset_prok
xref: EC:4.3.2
is_a: GO:0016840 ! carbon-nitrogen lyase activity

[Term]
id: GO:0016843
name: amine-lyase activity
namespace: molecular_function
def: "Catalysis of the release of amides by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amine as a substrate." [EC:4.3.-.-, GOC:krc]
subset: gosubset_prok
xref: EC:4.3.3
is_a: GO:0016840 ! carbon-nitrogen lyase activity

[Term]
id: GO:0016844
name: strictosidine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3alpha(S)-strictosidine + H(2)O = secologanin + tryptamine." [EC:4.3.3.2, RHEA:15016]
subset: gosubset_prok
synonym: "3-alpha(S)-strictosidine tryptamine-lyase (secologanin-forming)" EXACT [EC:4.3.3.2]
synonym: "3-alpha(S)-strictosidine tryptamine-lyase activity" EXACT [EC:4.3.3.2]
synonym: "STR activity" EXACT [EC:4.3.3.2]
synonym: "strictosidine synthetase activity" EXACT [EC:4.3.3.2]
xref: EC:4.3.3.2
xref: KEGG:R03738
xref: MetaCyc:STRICTOSIDINE-SYNTHASE-RXN
xref: RHEA:15016
is_a: GO:0016843 ! amine-lyase activity

[Term]
id: GO:0016845
name: obsolete other carbon-nitrogen lyase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of a carbon-nitrogen bond. Enzymes with this activity are 'miscellaneous' carbon-nitrogen lyases that cannot be grouped into one of the specific subclasses of the carbon-nitrogen lyases." [GOC:krc]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "other carbon-nitrogen lyase activity" EXACT []
is_obsolete: true
consider: GO:0016840

[Term]
id: GO:0016846
name: carbon-sulfur lyase activity
namespace: molecular_function
def: "Catalysis of the elimination of hydrogen sulfide or substituted H2S." [EC:4.4.-.-]
subset: gosubset_prok
synonym: "carbon-sulphur lyase activity" EXACT []
xref: EC:4.4
xref: Reactome:REACT_115918 "Excess homocysteine yields homolanthionine and H2S, Homo sapiens"
is_a: GO:0016829 ! lyase activity

[Term]
id: GO:0016847
name: 1-aminocyclopropane-1-carboxylate synthase activity
namespace: molecular_function
alt_id: GO:0034100
def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) = 1-aminocyclopropane-1-carboxylate + S-methyl-5'-thioadenosine + H(+)." [EC:4.4.1.14, RHEA:21747]
comment: Note that this function was formerly EC:4.1.99.4.
subset: gosubset_prok
synonym: "1-aminocyclopropane-1-carboxylate synthetase activity" EXACT [EC:4.4.1.14]
synonym: "1-aminocyclopropane-1-carboxylic acid synthase activity" EXACT [EC:4.4.1.14]
synonym: "1-aminocyclopropanecarboxylate synthase activity" EXACT [EC:4.4.1.14]
synonym: "ACC synthase activity" EXACT [EC:4.4.1.14]
synonym: "aminocyclopropanecarboxylate synthase activity" EXACT [EC:4.4.1.14]
synonym: "aminocyclopropanecarboxylic acid synthase activity" EXACT [EC:4.4.1.14]
synonym: "L-VG deaminase activity" RELATED [PMID:11470512]
synonym: "L-vinylglycine deaminase activity" RELATED [PMID:11470512]
synonym: "S-adenosyl-L-methionine methylthioadenosine-lyase (1-aminocyclopropane-1-carboxylate-forming)" EXACT [EC:4.4.1.14]
synonym: "S-adenosyl-L-methionine methylthioadenosine-lyase activity" EXACT [EC:4.4.1.14]
xref: EC:4.4.1.14
xref: KEGG:R00179
xref: MetaCyc:4.4.1.14-RXN
xref: RHEA:21747
is_a: GO:0016846 ! carbon-sulfur lyase activity
relationship: part_of GO:0042218 ! 1-aminocyclopropane-1-carboxylate biosynthetic process

[Term]
id: GO:0016848
name: carbon-halide lyase activity
namespace: molecular_function
def: "Catalysis of the breakage of a bond between carbon and any halogen atom." [GOC:mah]
subset: gosubset_prok
xref: EC:4.5
is_a: GO:0016829 ! lyase activity

[Term]
id: GO:0016849
name: phosphorus-oxygen lyase activity
namespace: molecular_function
def: "Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]
subset: gosubset_prok
xref: EC:4.6
is_a: GO:0016829 ! lyase activity

[Term]
id: GO:0016850
name: obsolete other lyase activity
namespace: molecular_function
def: "OBSOLETE. A grouping term for lyases that cannot be more accurately categorized." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "other lyase activity" EXACT []
is_obsolete: true
consider: GO:0016829

[Term]
id: GO:0016851
name: magnesium chelatase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H(2)O + Mg(2+) + protoporphyrin IX = ADP + 2 H(+) + magnesium protoporphyrin IX + phosphate." [EC:6.6.1.1, RHEA:13964]
comment: Note that this was EC:4.99.1.1.
subset: gosubset_prok
synonym: "magnesium-chelatase activity" EXACT [EC:6.6.1.1]
synonym: "magnesium-protoporphyrin chelatase activity" EXACT [EC:6.6.1.1]
synonym: "magnesium-protoporphyrin IX chelatase activity" EXACT [EC:6.6.1.1]
synonym: "Mg-chelatase activity" BROAD [EC:6.6.1.1]
synonym: "Mg-protoporphyrin IX chelatase activity" EXACT [EC:6.6.1.1]
synonym: "Mg-protoporphyrin IX magnesio-lyase activity" EXACT [EC:6.6.1.1]
synonym: "Mg-protoporphyrin IX magnesium-lyase activity" EXACT [EC:6.6.1.1]
synonym: "protoporphyrin IX magnesium-chelatase activity" EXACT [EC:6.6.1.1]
synonym: "protoporphyrin IX Mg-chelatase activity" EXACT [EC:6.6.1.1]
xref: EC:6.6.1.1
xref: KEGG:R03877
xref: MetaCyc:RXN1F-20
xref: RHEA:13964
is_a: GO:0051003 ! ligase activity, forming nitrogen-metal bonds, forming coordination complexes

[Term]
id: GO:0016852
name: sirohydrochlorin cobaltochelatase activity
namespace: molecular_function
def: "Catalysis of the reaction: sirohydrochlorin + Co2+ = cobalt-sirohydrochlorin + 2 H+." [EC:4.99.1.3]
subset: gosubset_prok
synonym: "anaerobic cobalt chelatase activity" EXACT []
synonym: "CbiK" NARROW []
synonym: "CbiX" RELATED [EC:4.99.1.3]
synonym: "CbiXS" RELATED [EC:4.99.1.3]
synonym: "cobalt-sirohydrochlorin cobalt-lyase (sirohydrochlorin-forming)" EXACT [EC:4.99.1.3]
synonym: "sirohydrochlorin cobalt-lyase activity" EXACT [EC:4.99.1.3]
xref: EC:4.99.1.3
xref: MetaCyc:4.99.1.3-RXN
xref: RHEA:15896
is_a: GO:0016829 ! lyase activity

[Term]
id: GO:0016853
name: isomerase activity
namespace: molecular_function
def: "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732]
comment: Note that enzymes of class EC:5.99.-.- should also be annotated to this term.
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
synonym: "other isomerase activity" NARROW []
xref: EC:5
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0016854
name: racemase and epimerase activity
namespace: molecular_function
def: "Catalysis of a reaction that alters the configuration of one or more chiral centers in a molecule." [GOC:mah, ISBN:0198506732]
comment: Note that enzymes of class EC:5.1.99.- should also be annotated to this term. Note that 'epimerase' refers to the conversion of an epimer into its diastereoisomer, and 'racemase' refers to the interconversion of the two enantiomers of a chiral compound.
subset: gosubset_prok
synonym: "racemase and epimerase activity, acting on other compounds" NARROW []
xref: EC:5.1
is_a: GO:0016853 ! isomerase activity

[Term]
id: GO:0016855
name: racemase and epimerase activity, acting on amino acids and derivatives
namespace: molecular_function
def: "Catalysis of a reaction that alters the configuration of one or more chiral centers in an amino acid." [GOC:mah]
subset: gosubset_prok
xref: EC:5.1.1
is_a: GO:0016854 ! racemase and epimerase activity

[Term]
id: GO:0016856
name: racemase and epimerase activity, acting on hydroxy acids and derivatives
namespace: molecular_function
def: "Catalysis of a reaction that alters the configuration of one or more chiral centers in a hydroxy acid molecule." [GOC:mah]
subset: gosubset_prok
xref: EC:5.1.2
is_a: GO:0016854 ! racemase and epimerase activity

[Term]
id: GO:0016857
name: racemase and epimerase activity, acting on carbohydrates and derivatives
namespace: molecular_function
def: "Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule." [GOC:mah]
subset: gosubset_prok
xref: EC:5.1.3
is_a: GO:0016854 ! racemase and epimerase activity

[Term]
id: GO:0016858
name: obsolete racemase and epimerase activity, acting on other compounds
namespace: molecular_function
def: "OBSOLETE. Racemase and epimerase activity on compounds other than amino acids, hydroxy acids, carbohydrates or their derivatives." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "racemase and epimerase activity, acting on other compounds" EXACT []
is_obsolete: true
consider: GO:0016854

[Term]
id: GO:0016859
name: cis-trans isomerase activity
namespace: molecular_function
def: "Catalysis of a reaction that interconverts cis and trans isomers. Atoms or groups are termed cis or trans to one another when they lie respectively on the same or on opposite sides of a reference plane identifiable as common among stereoisomers." [GOC:mah, ISBN:0198506732]
subset: gosubset_prok
xref: EC:5.2
is_a: GO:0016853 ! isomerase activity

[Term]
id: GO:0016860
name: intramolecular oxidoreductase activity
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears." [EC:5.3.-.-]
comment: Note that enzymes of class EC:5.3.99.- should also be annotated to this term.
subset: gosubset_prok
synonym: "intramolecular isomerase activity" EXACT []
synonym: "intramolecular oxidoreductase activity, other intramolecular oxidoreductases" NARROW []
xref: EC:5.3
xref: Reactome:REACT_102384 "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA, Rattus norvegicus"
xref: Reactome:REACT_106546 "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA, Taeniopygia guttata"
xref: Reactome:REACT_1445 "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA, Homo sapiens"
xref: Reactome:REACT_31586 "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA, Gallus gallus"
xref: Reactome:REACT_34789 "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA, Bos taurus"
xref: Reactome:REACT_79660 "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA, Canis familiaris"
xref: Reactome:REACT_80377 "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA, Mycobacterium tuberculosis"
xref: Reactome:REACT_85225 "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA, Mus musculus"
xref: Reactome:REACT_91641 "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA, Danio rerio"
xref: Reactome:REACT_93029 "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA, Drosophila melanogaster"
xref: Reactome:REACT_94432 "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA, Xenopus tropicalis"
is_a: GO:0016853 ! isomerase activity

[Term]
id: GO:0016861
name: intramolecular oxidoreductase activity, interconverting aldoses and ketoses
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is an aldose or a ketose, are the same molecule, and no oxidized product appears." [GOC:jl]
subset: gosubset_prok
synonym: "intramolecular isomerase activity, interconverting aldoses and ketoses" EXACT []
xref: EC:5.3.1
is_a: GO:0016860 ! intramolecular oxidoreductase activity

[Term]
id: GO:0016862
name: intramolecular oxidoreductase activity, interconverting keto- and enol-groups
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is a keto- or an enol-group, are the same molecule, and no oxidized product appears." [GOC:jl]
subset: gosubset_prok
synonym: "intramolecular isomerase activity, interconverting keto- and enol-groups" EXACT []
xref: EC:5.3.2
is_a: GO:0016860 ! intramolecular oxidoreductase activity

[Term]
id: GO:0016863
name: intramolecular oxidoreductase activity, transposing C=C bonds
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more carbon-carbon double bonds in the molecule are rearranged, and no oxidized product appears." [EC:5.3.3, GOC:mah]
subset: gosubset_prok
synonym: "intramolecular isomerase activity, transposing C=C bonds" EXACT []
xref: EC:5.3.3
is_a: GO:0016860 ! intramolecular oxidoreductase activity

[Term]
id: GO:0016864
name: intramolecular oxidoreductase activity, transposing S-S bonds
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more sulfur-sulfur bonds in the molecule are rearranged, and no oxidized product appears." [EC:5.3.4, GOC:mah]
subset: gosubset_prok
synonym: "intramolecular isomerase activity, transposing S-S bonds" EXACT []
xref: EC:5.3.4
is_a: GO:0016860 ! intramolecular oxidoreductase activity

[Term]
id: GO:0016865
name: obsolete intramolecular oxidoreductase activity, other intramolecular oxidoreductases
namespace: molecular_function
def: "OBSOLETE. A grouping term for intramolecular oxidoreductases that cannot be more accurately categorized." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "intramolecular isomerase activity, other intramolecular oxidoreductases" EXACT []
synonym: "intramolecular oxidoreductase activity, other intramolecular oxidoreductases" EXACT []
is_obsolete: true
consider: GO:0016860

[Term]
id: GO:0016866
name: intramolecular transferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a functional group from one position to another within a single molecule." [GOC:mah]
comment: Note that enzymes of class EC:5.4.99.- should also be annotated to this term.
subset: gosubset_prok
synonym: "intramolecular transferase activity, transferring other groups" NARROW []
synonym: "mutase activity" EXACT []
xref: EC:5.4
is_a: GO:0016853 ! isomerase activity

[Term]
id: GO:0016867
name: intramolecular transferase activity, transferring acyl groups
namespace: molecular_function
def: "Catalysis of the transfer of an acyl group from one position to another within a single molecule." [GOC:mah]
subset: gosubset_prok
xref: EC:5.4.1
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0016868
name: intramolecular transferase activity, phosphotransferases
namespace: molecular_function
alt_id: GO:0016777
def: "Catalysis of the transfer of a phosphate group from one position to another within a single molecule." [GOC:mah]
subset: gosubset_prok
synonym: "phosphomutase activity" EXACT []
synonym: "phosphotransferase activity, with regeneration of donors, apparently catalyzing intramolecular transfers" EXACT []
xref: EC:5.4.2
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0016869
name: intramolecular transferase activity, transferring amino groups
namespace: molecular_function
def: "Catalysis of the transfer of an amino group from one position to another within a single molecule." [GOC:mah]
subset: gosubset_prok
xref: EC:5.4.3
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0016870
name: obsolete intramolecular transferase activity, transferring other groups
namespace: molecular_function
def: "OBSOLETE. A grouping term for intramolecular transferases that cannot be more accurately categorized." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "intramolecular transferase activity, transferring other groups" EXACT []
is_obsolete: true
consider: GO:0016866

[Term]
id: GO:0016871
name: cycloartenol synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-2,3-epoxysqualene = cycloartenol." [EC:5.4.99.8, RHEA:21311]
subset: gosubset_prok
synonym: "(S)-2,3-epoxysqualene mutase (cyclizing, cycloartenol-forming)" EXACT [EC:5.4.99.8]
synonym: "2,3-epoxysqualene cycloartenol-cyclase activity" EXACT [EC:5.4.99.8]
synonym: "2,3-epoxysqualene--cycloartenol cyclase activity" EXACT [EC:5.4.99.8]
synonym: "2,3-oxidosqualene-cycloartenol cyclase activity" EXACT [EC:5.4.99.8]
synonym: "oxidosqualene:cycloartenol cyclase activity" EXACT [PMID:18033581]
synonym: "squalene-2,3-epoxide-cycloartenol cyclase activity" EXACT [EC:5.4.99.8]
xref: EC:5.4.99.8
xref: KEGG:R03200
xref: MetaCyc:CYCLOARTENOL-SYNTHASE-RXN
xref: RHEA:21311
is_a: GO:0031559 ! oxidosqualene cyclase activity

[Term]
id: GO:0016872
name: intramolecular lyase activity
namespace: molecular_function
def: "The catalysis of certain rearrangements of a molecule to break or form a ring." [GOC:jl, http://www.mercksource.com/]
subset: gosubset_prok
xref: EC:5.5
is_a: GO:0016853 ! isomerase activity

[Term]
id: GO:0016873
name: obsolete other isomerase activity
namespace: molecular_function
def: "OBSOLETE. A grouping term for isomerases that cannot be more accurately categorized." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "other isomerase activity" EXACT []
is_obsolete: true
consider: GO:0016853

[Term]
id: GO:0016874
name: ligase activity
namespace: molecular_function
def: "Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
synonym: "synthetase activity" EXACT [GOC:jh2]
xref: EC:6
xref: Reactome:REACT_115603 "Ligation of DNA at sites of patch replacement, Gallus gallus"
xref: Reactome:REACT_116018 "Ligation of newly synthesized repair patch to incised DNA in GG-NER, Gallus gallus"
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0016875
name: ligase activity, forming carbon-oxygen bonds
namespace: molecular_function
def: "Catalysis of the joining of two molecules via a carbon-oxygen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.1, GOC:mah]
subset: gosubset_prok
xref: EC:6.1
is_a: GO:0016874 ! ligase activity

[Term]
id: GO:0016876
name: ligase activity, forming aminoacyl-tRNA and related compounds
namespace: molecular_function
def: "Catalysis of the joining of an amino acid and a nucleic acid (usually tRNA) or poly(ribitol phosphate), with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. The reaction forms an aminoacyl-tRNA or a related compound." [EC:6.1.1, GOC:mah]
subset: gosubset_prok
xref: EC:6.1.1
is_a: GO:0016875 ! ligase activity, forming carbon-oxygen bonds

[Term]
id: GO:0016877
name: ligase activity, forming carbon-sulfur bonds
namespace: molecular_function
def: "Catalysis of the joining of two molecules via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.2, GOC:mah]
subset: gosubset_prok
synonym: "ligase activity, forming carbon-sulphur bonds" EXACT []
xref: EC:6.2
is_a: GO:0016874 ! ligase activity

[Term]
id: GO:0016878
name: acid-thiol ligase activity
namespace: molecular_function
def: "Catalysis of the joining of an acid and a thiol via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.2.1, GOC:mah]
subset: gosubset_prok
xref: EC:6.2.1
is_a: GO:0016877 ! ligase activity, forming carbon-sulfur bonds

[Term]
id: GO:0016879
name: ligase activity, forming carbon-nitrogen bonds
namespace: molecular_function
def: "Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.3, GOC:mah]
comment: Note that enzymes of class EC:6.3.4.- should also be annotated to this term.
subset: gosubset_prok
synonym: "other carbon-nitrogen ligase activity" NARROW []
xref: EC:6.3
is_a: GO:0016874 ! ligase activity

[Term]
id: GO:0016880
name: acid-ammonia (or amide) ligase activity
namespace: molecular_function
def: "Catalysis of the ligation of an acid to ammonia (NH3) or an amide via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]
subset: gosubset_prok
synonym: "amide synthase activity" EXACT []
xref: EC:6.3.1
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0016881
name: acid-amino acid ligase activity
namespace: molecular_function
def: "Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]
subset: gosubset_prok
synonym: "peptide synthase activity" EXACT []
xref: EC:6.3.2
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0016882
name: cyclo-ligase activity
namespace: molecular_function
def: "Catalysis of the joining of two groups within a single molecule via a carbon-nitrogen bond, forming heterocyclic ring, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.3.3.1, EC:6.3.3.2, EC:6.3.3.4, GOC:jl, GOC:mah]
subset: gosubset_prok
xref: EC:6.3.3
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0016883
name: obsolete other carbon-nitrogen ligase activity
namespace: molecular_function
def: "OBSOLETE. A grouping term for carbon-nitrogen ligases that cannot be more accurately categorized." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "other carbon-nitrogen ligase activity" EXACT []
is_obsolete: true
consider: GO:0016879

[Term]
id: GO:0016884
name: carbon-nitrogen ligase activity, with glutamine as amido-N-donor
namespace: molecular_function
alt_id: GO:0016003
def: "Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction." [PMID:12360532]
subset: gosubset_prok
xref: EC:6.3.5
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0016885
name: ligase activity, forming carbon-carbon bonds
namespace: molecular_function
def: "Catalysis of the joining of two molecules via a carbon-carbon bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.4, GOC:jl, GOC:mah]
subset: gosubset_prok
xref: EC:6.4
is_a: GO:0016874 ! ligase activity

[Term]
id: GO:0016886
name: ligase activity, forming phosphoric ester bonds
namespace: molecular_function
def: "Catalysis of the joining of two molecules, or two groups within a single molecule, via a phosphoric ester bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.5, GOC:mah]
subset: gosubset_prok
xref: EC:6.5
is_a: GO:0016874 ! ligase activity

[Term]
id: GO:0016887
name: ATPase activity
namespace: molecular_function
alt_id: GO:0004002
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_yeast
subset: gosubset_prok
synonym: "(Ca2+ + Mg2+)-ATPase" NARROW [EC:3.6.1.3]
synonym: "adenosine 5'-triphosphatase activity" EXACT [EC:3.6.1.3]
synonym: "adenosine triphosphatase activity" EXACT [EC:3.6.1.3]
synonym: "adenosinetriphosphatase activity" EXACT []
synonym: "ATP hydrolase activity" EXACT [EC:3.6.1.3]
synonym: "ATP monophosphatase activity" EXACT [EC:3.6.1.3]
synonym: "ATP phosphohydrolase activity" EXACT []
synonym: "complex V (mitochondrial electron transport)" RELATED [EC:3.6.1.3]
synonym: "HCO3--ATPase" NARROW [EC:3.6.1.3]
synonym: "SV40 T-antigen" RELATED [EC:3.6.1.3]
xref: EC:3.6.1.3
xref: MetaCyc:ADENOSINETRIPHOSPHATASE-RXN
xref: Reactome:REACT_100141 "Trafficking of GluR2-containing AMPA receptors to synapse, Canis familiaris"
xref: Reactome:REACT_108873 "Trafficking of GluR2-containing AMPA receptors to synapse, Bos taurus"
xref: Reactome:REACT_110992 "Trafficking of GluR2-containing AMPA receptors to synapse, Danio rerio"
xref: Reactome:REACT_113271 "Trafficking of GluR2-containing AMPA receptors to synapse, Xenopus tropicalis"
xref: Reactome:REACT_18320 "Trafficking of GluR2-containing AMPA receptors to synapse, Homo sapiens"
xref: Reactome:REACT_27184 "ESCRT Disassembly, Homo sapiens"
xref: Reactome:REACT_33329 "Trafficking of GluR2-containing AMPA receptors to synapse, Gallus gallus"
xref: Reactome:REACT_79964 "Trafficking of GluR2-containing AMPA receptors to synapse, Mus musculus"
xref: Reactome:REACT_84196 "Trafficking of GluR2-containing AMPA receptors to synapse, Drosophila melanogaster"
xref: Reactome:REACT_87020 "Trafficking of GluR2-containing AMPA receptors to synapse, Rattus norvegicus"
xref: Reactome:REACT_89934 "Trafficking of GluR2-containing AMPA receptors to synapse, Taeniopygia guttata"
xref: RHEA:13068
is_a: GO:0017111 ! nucleoside-triphosphatase activity

[Term]
id: GO:0016888
name: endodeoxyribonuclease activity, producing 5'-phosphomonoesters
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai]
subset: gosubset_prok
synonym: "endodeoxyribonuclease activity, producing 5' phosphomonoesters" EXACT []
xref: EC:3.1.21
xref: Reactome:REACT_27139 "Formation of Double-strand Break in DNA by Spo11, Mus musculus"
xref: Reactome:REACT_27239 "Formation of Double-strand Break in DNA by SPO11, Homo sapiens"
is_a: GO:0004520 ! endodeoxyribonuclease activity
is_a: GO:0016893 ! endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters

[Term]
id: GO:0016889
name: endodeoxyribonuclease activity, producing 3'-phosphomonoesters
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters." [GOC:ai]
subset: gosubset_prok
synonym: "endodeoxyribonuclease activity, producing other than 5'-phosphomonoesters" EXACT []
xref: EC:3.1.22
is_a: GO:0004520 ! endodeoxyribonuclease activity
is_a: GO:0016894 ! endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters

[Term]
id: GO:0016890
name: site-specific endodeoxyribonuclease activity, specific for altered base
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages at specific sites within a deoxyribonucleic acid molecule by creating internal breaks." [GOC:jl]
subset: gosubset_prok
xref: EC:3.1.25
is_a: GO:0004520 ! endodeoxyribonuclease activity

[Term]
id: GO:0016891
name: endoribonuclease activity, producing 5'-phosphomonoesters
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai]
subset: gosubset_prok
xref: EC:3.1.26
is_a: GO:0004521 ! endoribonuclease activity
is_a: GO:0016893 ! endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters

[Term]
id: GO:0016892
name: endoribonuclease activity, producing 3'-phosphomonoesters
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters." [GOC:ai]
subset: gosubset_prok
synonym: "endoribonuclease activity, producing other than 5'-phosphomonoesters" EXACT []
xref: EC:3.1.27
is_a: GO:0004521 ! endoribonuclease activity
is_a: GO:0016894 ! endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters

[Term]
id: GO:0016893
name: endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:mah]
comment: Note that this activity can catalyze cleavage of DNA or RNA.
subset: gosubset_prok
synonym: "5'-endonuclease activity" EXACT []
synonym: "endoribonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters" RELATED []
xref: EC:3.1.30
is_a: GO:0004519 ! endonuclease activity

[Term]
id: GO:0016894
name: endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 3'-phosphomonoesters." [GOC:mah]
comment: Note that this activity can catalyze cleavage of DNA or RNA.
subset: gosubset_prok
synonym: "3'-endonuclease activity" EXACT []
synonym: "endoribonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters" RELATED []
xref: EC:3.1.31
is_a: GO:0004519 ! endonuclease activity

[Term]
id: GO:0016895
name: exodeoxyribonuclease activity, producing 5'-phosphomonoesters
namespace: molecular_function
alt_id: GO:0008858
def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters." [GOC:ai]
subset: gosubset_prok
synonym: "exodeoxyribonuclease activity, producing 5' phosphomonoesters" EXACT []
synonym: "exonuclease VIII activity" NARROW []
xref: EC:3.1.11
is_a: GO:0004529 ! exodeoxyribonuclease activity
is_a: GO:0016796 ! exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters

[Term]
id: GO:0016896
name: exoribonuclease activity, producing 5'-phosphomonoesters
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within ribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters." [GOC:ai]
subset: gosubset_prok
synonym: "exoribonuclease activity, producing 5' phosphomonoesters" EXACT []
xref: EC:3.1.13
xref: Reactome:REACT_109371 "Decapping of mRNA by the DCP1-DCP2 Complex, Xenopus tropicalis"
xref: Reactome:REACT_20560 "Decapping of mRNA by the DCP1-DCP2 Complex, Homo sapiens"
xref: Reactome:REACT_81094 "Decapping of mRNA by the DCP1-DCP2 Complex, Taeniopygia guttata"
xref: Reactome:REACT_89209 "Decapping of mRNA by the DCP1-DCP2 Complex, Bos taurus"
xref: Reactome:REACT_90720 "Decapping of mRNA by the DCP1-DCP2 Complex, Mus musculus"
xref: Reactome:REACT_92855 "Decapping of mRNA by the DCP1-DCP2 Complex, Gallus gallus"
xref: Reactome:REACT_93863 "Decapping of mRNA by the DCP1-DCP2 Complex, Danio rerio"
xref: Reactome:REACT_97640 "Decapping of mRNA by the DCP1-DCP2 Complex, Canis familiaris"
xref: Reactome:REACT_98936 "Decapping of mRNA by the DCP1-DCP2 Complex, Drosophila melanogaster"
is_a: GO:0004532 ! exoribonuclease activity
is_a: GO:0016796 ! exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters

[Term]
id: GO:0016897
name: exoribonuclease activity, producing 3'-phosphomonoesters
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within ribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 3' phosphomonoesters." [GOC:ai]
xref: EC:3.1.14
is_a: GO:0004532 ! exoribonuclease activity
is_a: GO:0016797 ! exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters

[Term]
id: GO:0016898
name: oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a cytochrome molecule." [GOC:ai]
subset: gosubset_prok
xref: EC:1.1.2
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0016899
name: oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai]
subset: gosubset_prok
xref: EC:1.1.3
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0016900
name: oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a disulfide molecule." [GOC:ai]
synonym: "oxidoreductase activity, acting on the CH-OH group of donors, disulphide as acceptor" EXACT []
xref: EC:1.1.4
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0016901
name: oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule." [GOC:ai]
subset: gosubset_prok
xref: EC:1.1.5
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0016902
name: obsolete oxidoreductase activity, acting on the CH-OH group of donors, other acceptors
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces an acceptor other than a cytochrome, disulfide, NAD, NADP, oxygen or a quinone or similar compound." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "oxidoreductase activity, acting on the CH-OH group of donors, other acceptors" EXACT []
is_obsolete: true
consider: GO:0016614

[Term]
id: GO:0016903
name: oxidoreductase activity, acting on the aldehyde or oxo group of donors
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
comment: Note that enzymes of class EC:1.2.99.- should also be annotated to this term.
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on the aldehyde or oxo group of donors, other acceptors" NARROW []
xref: EC:1.2
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016905
name: myosin heavy chain kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + myosin-heavy-chain = ADP + myosin-heavy-chain phosphate." [EC:2.7.11.7]
synonym: "ATP:myosin heavy-chain O-phosphotransferase activity" EXACT [EC:2.7.11.7]
synonym: "ATP:myosin-heavy-chain O-phosphotransferase activity" EXACT [EC:2.7.11.7]
synonym: "calmodulin-dependent myosin heavy chain kinase activity" EXACT [EC:2.7.11.7]
synonym: "MHCK" RELATED [EC:2.7.11.7]
synonym: "MIHC kinase activity" EXACT [EC:2.7.11.7]
synonym: "myosin heavy chain kinase A activity" EXACT [EC:2.7.11.7]
synonym: "myosin heavy-chain kinase activity" EXACT [EC:2.7.11.7]
synonym: "myosin I heavy chain kinase activity" NARROW [EC:2.7.11.7]
synonym: "myosin I heavy-chain kinase activity" NARROW [EC:2.7.11.7]
synonym: "myosin II heavy chain kinase activity" NARROW [EC:2.7.11.7]
synonym: "myosin II heavy-chain kinase activity" NARROW [EC:2.7.11.7]
synonym: "myosin-heavy-chain kinase activity" EXACT [EC:2.7.11.7]
synonym: "STK6" RELATED [EC:2.7.11.7]
xref: EC:2.7.11.7
is_a: GO:0004683 ! calmodulin-dependent protein kinase activity

[Term]
id: GO:0016906
name: sterol 3-beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + a sterol = UDP + an O-glucosylsterol." [EC:2.4.1.173]
synonym: "sterol 3beta-glucosyltransferase activity" EXACT [EC:2.4.1.173]
synonym: "sterol glucosyltransferase activity" EXACT []
synonym: "sterol-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.173]
synonym: "sterol:UDPG glucosyltransferase activity" EXACT []
synonym: "UDP-glucose-sterol beta-glucosyltransferase activity" EXACT [EC:2.4.1.173]
synonym: "UDP-glucose-sterol glucosyltransferase activity" EXACT [EC:2.4.1.173]
synonym: "UDP-glucose:sterol 3-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.173]
synonym: "UDP-glucose:sterol glucosyltransferase activity" EXACT []
synonym: "UDPG-SGTase activity" EXACT [EC:2.4.1.173]
synonym: "UDPG:sterol glucosyltransferase activity" EXACT []
synonym: "UDPglucose:sterol 3-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.173]
synonym: "uridine diphosphoglucose-poriferasterol glucosyltransferase activity" EXACT [EC:2.4.1.173]
synonym: "uridine diphosphoglucose-sterol glucosyltransferase activity" EXACT [EC:2.4.1.173]
xref: EC:2.4.1.173
xref: MetaCyc:STEROL-GLUCOSYLTRANSFERASE-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0016907
name: G-protein coupled acetylcholine receptor activity
namespace: molecular_function
alt_id: GO:0004981
def: "Combining with acetylcholine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:fj, GOC:mah]
synonym: "acetylcholine receptor activity, G-protein coupled" EXACT [GOC:bf]
synonym: "G protein coupled acetylcholine receptor activity" EXACT []
synonym: "G-protein-coupled acetylcholine receptor activity" EXACT []
synonym: "muscarinic acetylcholine receptor activity" EXACT []
is_a: GO:0008227 ! G-protein coupled amine receptor activity
is_a: GO:0015464 ! acetylcholine receptor activity
is_a: GO:0099528 ! G-protein coupled neurotransmitter receptor activity
relationship: part_of GO:0007213 ! G-protein coupled acetylcholine receptor signaling pathway

[Term]
id: GO:0016909
name: SAP kinase activity
namespace: molecular_function
def: "Catalysis of the phosphorylation of proteins. A family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. Strongly activated by stress signals such as heat or osmotic shock, DNA-damaging agents, inhibitors of protein synthesis and pro-inflammatory cytokines." [GOC:ma]
synonym: "SAPK" EXACT []
synonym: "stress-activated kinase activity" EXACT []
synonym: "stress-activated protein kinase activity" EXACT []
xref: EC:2.7.11.-
is_a: GO:0004707 ! MAP kinase activity

[Term]
id: GO:0016910
name: obsolete SAP kinase 3 activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it describes a gene product.
synonym: "SAP kinase 3 activity" EXACT []
synonym: "SAPK3" EXACT []
is_obsolete: true
consider: GO:0004674
consider: GO:0004871
consider: GO:0007254

[Term]
id: GO:0016911
name: obsolete SAP kinase 4 activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it describes a gene product.
synonym: "SAP kinase 4 activity" EXACT []
synonym: "SAPK4" EXACT []
is_obsolete: true
consider: GO:0004674
consider: GO:0004871
consider: GO:0007254

[Term]
id: GO:0016912
name: obsolete SAP kinase 5 activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because there are no known gene products that would be described as 'SAP kinase 5', and the term name implies that it refers to a gene product.
synonym: "SAP kinase 5 activity" EXACT []
synonym: "SAPK5" EXACT []
is_obsolete: true
consider: GO:0004674
consider: GO:0004871
consider: GO:0007254

[Term]
id: GO:0016913
name: follicle-stimulating hormone activity
namespace: molecular_function
def: "The action characteristic of follicle-stimulating hormone (FSH), a gonadotrophic glycoprotein hormone secreted, in mammals, by the anterior pituitary gland. Upon receptor binding, FSH stimulates growth of Graafian follicles in the ovaries in females, and stimulates the epithelium of the seminiferous tubules to increase spermatogenesis." [ISBN:0198547684]
synonym: "follicle stimulating hormone activity" EXACT []
synonym: "follitropin activity" EXACT [ISBN:0198506732]
synonym: "FSH activity" EXACT [GOC:mah]
is_a: GO:0005179 ! hormone activity

[Term]
id: GO:0016914
name: follicle-stimulating hormone complex
namespace: cellular_component
def: "A gonadotrophic glycoprotein hormone secreted, in mammals, by the anterior pituitary gland; consists of alpha and beta subunits, the latter of which confers hormonal specificity." [ISBN:0198547684]
synonym: "follicle stimulating hormone complex" EXACT []
synonym: "FSH complex" EXACT []
is_a: GO:0061696 ! pituitary gonadotropin complex

[Term]
id: GO:0016915
name: obsolete activin
namespace: molecular_function
def: "OBSOLETE. A nonsteroidal regulator, composed of two covalently linked beta subunits, that is synthesized in the pituitary gland and gonads and stimulates the secretion of follicle-stimulating hormone." [ISBN:0198506732, ISBN:0721662544]
comment: This term was made obsolete because it represents a gene product.
synonym: "activin" EXACT []
is_obsolete: true
consider: GO:0005160
consider: GO:0046881

[Term]
id: GO:0016916
name: obsolete inhibin
namespace: molecular_function
def: "OBSOLETE. Either of two glycoproteins (designated A and B), secreted by the gonads and present in seminal plasma and follicular fluid, that inhibit pituitary production of follicle-stimulating hormone." [ISBN:0198506732, ISBN:0721662544]
comment: This term was made obsolete because it represents a gene product.
synonym: "inhibin" EXACT []
is_obsolete: true
consider: GO:0005160
consider: GO:0046882

[Term]
id: GO:0016917
name: GABA receptor activity
namespace: molecular_function
def: "Combining with gamma-aminobutyric acid (GABA), and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. (GABA, 4-aminobutyrate) is an amino acid which acts as a neurotransmitter in some organisms." [GOC:jl, GOC:signaling, PMID:10637650]
comment: See also the molecular function term 'neurotransmitter receptor activity ; GO:0030594'.
synonym: "4-aminobutanoate receptor activity" EXACT []
synonym: "4-aminobutyrate receptor activity" EXACT []
synonym: "GABA binding" EXACT []
synonym: "gamma-aminobutyrate binding" EXACT []
synonym: "gamma-aminobutyric acid binding" EXACT []
synonym: "gamma-aminobutyric acid receptor activity" EXACT []
is_a: GO:0004888 ! transmembrane signaling receptor activity

[Term]
id: GO:0016918
name: retinal binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with retinal, one of the forms of vitamin A. Retinal plays an important role in the visual process in most vertebrates, combining with opsins to form visual pigments in the retina." [CHEBI:15035, GOC:curators, ISBN:0198506732]
synonym: "blue-sensitive opsin" RELATED []
synonym: "green-sensitive opsin" RELATED []
synonym: "long-wave-sensitive opsin" RELATED []
synonym: "opsin" RELATED []
synonym: "red-sensitive opsin" RELATED []
synonym: "retinaldehyde binding" EXACT []
synonym: "short-wave-sensitive opsin" RELATED []
synonym: "UV-sensitive opsin" RELATED []
synonym: "violet-sensitive opsin" RELATED []
synonym: "vitamin A binding" BROAD []
is_a: GO:0005501 ! retinoid binding
is_a: GO:0019842 ! vitamin binding

[Term]
id: GO:0016919
name: obsolete nardilysin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of polypeptides, preferably at the first bond of Xaa-Arg-Lys, and less commonly at the first bond of Arg-Arg-Xaa, in which Xaa is not Arg or Lys." [EC:3.4.24.61]
comment: This term was made obsolete because it represents a gene product.
synonym: "N-arginine dibasic convertase activity" EXACT [EC:3.4.24.61]
synonym: "nardilysin activity" EXACT []
synonym: "NRD convertase activity" EXACT [EC:3.4.24.61]
synonym: "NRD-convertase activity" EXACT [EC:3.4.24.61]
xref: EC:3.4.24.61
xref: MetaCyc:3.4.24.61-RXN
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0016920
name: pyroglutamyl-peptidase activity
namespace: molecular_function
def: "Catalysis of the release of the N-terminal pyroglutamyl group from a peptide or protein." [EC:3.4.19.3, EC:3.4.19.6, GOC:mah]
subset: gosubset_prok
xref: EC:3.4.19.-
is_a: GO:0008242 ! omega peptidase activity

[Term]
id: GO:0016921
name: obsolete pyroglutamyl-peptidase II activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of the N-terminal pyroglutamyl group from pGlu-His-Xaa tripeptides and pGlu-His-Xaa-Gly tetrapeptides." [EC:3.4.19.6]
comment: This term was made obsolete because it represents a gene product.
synonym: "PAP-II activity" EXACT [EC:3.4.19.6]
synonym: "pyroglutamate aminopeptidase II" RELATED [EC:3.4.19.6]
synonym: "pyroglutamyl aminopeptidase II activity" EXACT [EC:3.4.19.6]
synonym: "pyroglutamyl peptidase II" RELATED [EC:3.4.19.6]
synonym: "pyroglutamyl-peptidase II activity" EXACT []
synonym: "thyroliberin-hydrolyzing pyroglutamate aminopeptidase activity" EXACT [EC:3.4.19.6]
synonym: "thyroliberinase activity" NARROW [EC:3.4.19.6]
synonym: "thyrotropin-releasing factor pyroglutamate aminopeptidase activity" EXACT [EC:3.4.19.6]
synonym: "thyrotropin-releasing hormone degrading ectoenzyme activity" NARROW [EC:3.4.19.6]
synonym: "thyrotropin-releasing hormone-degrading peptidase activity" EXACT [EC:3.4.19.6]
synonym: "thyrotropin-releasing hormone-degrading pyroglutamate aminopeptidase activity" EXACT [EC:3.4.19.6]
synonym: "TRH-DE activity" NARROW [EC:3.4.19.6]
synonym: "TRH-degrading ectoenzyme activity" NARROW [EC:3.4.19.6]
synonym: "TRH-specific aminopeptidase activity" NARROW [EC:3.4.19.6]
xref: EC:3.4.19.6
xref: MetaCyc:3.4.19.6-RXN
is_obsolete: true
consider: GO:0008237
consider: GO:0016920

[Term]
id: GO:0016922
name: ligand-dependent nuclear receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently, in a ligand dependent manner, with a nuclear receptor protein." [GOC:mah, PMID:7776974]
synonym: "ligand-dependent nuclear receptor interactor activity" RELATED []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0016923
name: obsolete ligand-dependent thyroid hormone receptor interactor activity
namespace: molecular_function
def: "OBSOLETE. Ligand dependent interaction with the thyroid hormone receptor." [PMID:7776974]
comment: This term was made obsolete because it represents a gene product and not a molecular function.
synonym: "ligand-dependent thyroid hormone receptor interactor activity" EXACT []
synonym: "TRIP4" RELATED []
is_obsolete: true
consider: GO:0046966

[Term]
id: GO:0016925
name: protein sumoylation
namespace: biological_process
alt_id: GO:0006485
alt_id: GO:0016927
def: "The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxyl terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein." [GOC:jl, PMID:11265250]
synonym: "protein sumolation" EXACT []
synonym: "small ubiquitin-related protein 1 conjugation" EXACT []
synonym: "SUMO-protein conjugation" EXACT []
synonym: "sumoylation" EXACT []
xref: Wikipedia:SUMO_protein
is_a: GO:0018205 ! peptidyl-lysine modification
is_a: GO:0032446 ! protein modification by small protein conjugation

[Term]
id: GO:0016926
name: protein desumoylation
namespace: biological_process
alt_id: GO:0016928
def: "The process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein." [GOC:jl, PMID:11265250]
synonym: "desumoylation" EXACT []
synonym: "protein desumolation" EXACT []
is_a: GO:0018205 ! peptidyl-lysine modification
is_a: GO:0070646 ! protein modification by small protein removal

[Term]
id: GO:0016929
name: SUMO-specific protease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of SUMO, a small ubiquitin-related modifier, from previously sumoylated substrates." [GOC:rn, PMID:10094048, PMID:11031248, PMID:11265250]
synonym: "SUSP" NARROW []
synonym: "ULP" NARROW []
is_a: GO:0019783 ! ubiquitin-like protein-specific protease activity

[Term]
id: GO:0016933
name: extracellular-glycine-gated ion channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of an ion by a channel that opens when extracellular glycine has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
synonym: "glycine receptor" BROAD []
is_a: GO:0005231 ! excitatory extracellular ligand-gated ion channel activity

[Term]
id: GO:0016934
name: extracellular-glycine-gated chloride channel activity
namespace: molecular_function
alt_id: GO:0004891
def: "Enables the transmembrane transfer of a chloride ion by a channel that opens when extracellular glycine has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'receptor activity ; GO:0004872'.
synonym: "glycine receptor" BROAD []
synonym: "glycine-inhibited chloride channel activity" RELATED []
xref: Reactome:REACT_25304 "The glycine receptor complex is permeable to Cl- when glycine binds to it, Homo sapiens"
is_a: GO:0005237 ! inhibitory extracellular ligand-gated ion channel activity
is_a: GO:0005254 ! chloride channel activity
is_a: GO:0016933 ! extracellular-glycine-gated ion channel activity

[Term]
id: GO:0016935
name: glycine-gated chloride channel complex
namespace: cellular_component
def: "A protein complex that forms a transmembrane channel through which chloride ions may pass in response to glycine binding to the channel complex or one of its constituent parts." [GOC:mah]
is_a: GO:0034707 ! chloride channel complex
is_a: GO:0098797 ! plasma membrane protein complex
relationship: part_of GO:0005887 ! integral component of plasma membrane

[Term]
id: GO:0016936
name: galactoside binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any glycoside in which the sugar group is galactose." [CHEBI:24163, GOC:jl, ISBN:0198506732]
subset: goslim_chembl
is_a: GO:0097367 ! carbohydrate derivative binding

[Term]
id: GO:0016937
name: short-branched-chain-acyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a short branched chain fatty acid residue." [GOC:mah]
xref: EC:1.3.99.-
is_a: GO:0003995 ! acyl-CoA dehydrogenase activity

[Term]
id: GO:0016938
name: kinesin I complex
namespace: cellular_component
def: "A complex of two kinesin heavy chains and two kinesin light chains." [http://www.csfic.mi.cnr.it/centro/lines/8/ric.html]
is_a: GO:0005871 ! kinesin complex

[Term]
id: GO:0016939
name: kinesin II complex
namespace: cellular_component
def: "A complex consisting of two distinct motor subunits that form a heterodimer complexed with a third non-motor accessory subunit, the kinesin associated protein or KAP; the KIF3 heterodimer interacts via its C-terminal portion with KAP, which is thought to regulate the binding of the motor to cargo membranes." [http://www.csfic.mi.cnr.it/centro/lines/8/ric.html]
is_a: GO:0005871 ! kinesin complex

[Term]
id: GO:0016941
name: natriuretic peptide receptor activity
namespace: molecular_function
def: "Combining with a natriuretic peptide and transmitting the signal to initiate a change in cell activity." [GOC:mah, GOC:signaling]
is_a: GO:0001653 ! peptide receptor activity

[Term]
id: GO:0016942
name: insulin-like growth factor binding protein complex
namespace: cellular_component
def: "A complex of proteins which includes the insulin-like growth factor (IGF) and a number of IGF-binding proteins. The complex plays a role in growth and development." [GOC:jl]
subset: goslim_pir
synonym: "IGF binding protein complex" EXACT []
is_a: GO:0036454 ! growth factor complex
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0016943
name: obsolete RNA polymerase I transcription elongation factor activity
namespace: molecular_function
def: "OBSOLETE. Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule catalyzed by RNA polymerase I following transcription initiation." [GOC:mah]
comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
synonym: "Pol I transcription elongation factor activity" EXACT []
synonym: "RNA polymerase I transcription elongation factor activity" EXACT []
is_obsolete: true
consider: GO:0006362

[Term]
id: GO:0016944
name: obsolete RNA polymerase II transcription elongation factor activity
namespace: molecular_function
def: "OBSOLETE. Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule catalyzed by RNA polymerase II following transcription initiation." [GOC:mah]
comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
synonym: "Pol II transcription elongation factor activity" EXACT []
synonym: "RNA polymerase II transcription elongation factor activity" EXACT []
is_obsolete: true
consider: GO:0006368

[Term]
id: GO:0016945
name: obsolete RNA polymerase III transcription elongation factor activity
namespace: molecular_function
def: "OBSOLETE. Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule catalyzed by RNA polymerase III following transcription initiation." [GOC:mah]
comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
synonym: "Pol III transcription elongation factor activity" EXACT []
synonym: "RNA polymerase III transcription elongation factor activity" EXACT []
is_obsolete: true
consider: GO:0006385

[Term]
id: GO:0016946
name: obsolete cathepsin F activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Cleavage of substrates with Phe and Leu in P2." [EC:3.4.22.41]
comment: This term was made obsolete because it represents a gene product.
synonym: "cathepsin F activity" EXACT []
xref: EC:3.4.22.41
xref: MetaCyc:3.4.22.41-RXN
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0016962
name: obsolete receptor-associated protein activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it describes a gene product and not a molecular function.
synonym: "receptor-associated protein activity" EXACT []
is_obsolete: true
consider: GO:0005102
consider: GO:0005515

[Term]
id: GO:0016963
name: obsolete alpha-2 macroglobulin receptor-associated protein activity
namespace: molecular_function
def: "OBSOLETE. Interaction with the alpha-2 macroglobulin receptor and glycoprotein gp330 forming a complex with the alpha-2 macroglobulin receptor light and heavy chains." [GOC:curators]
comment: This term was made obsolete because it represents a gene product and not a molecular function.
synonym: "alpha-2 macroglobulin receptor-associated protein activity" EXACT []
is_obsolete: true
consider: GO:0005102
consider: GO:0005515

[Term]
id: GO:0016964
name: alpha-2 macroglobulin receptor activity
namespace: molecular_function
def: "Combining with alpha-2 macroglobulin and delivering alpha-2 macroglobulin into the cell via receptor-mediated endocytosis." [GOC:bf, GOC:ma, PMID:6188403]
is_a: GO:0038024 ! cargo receptor activity

[Term]
id: GO:0016966
name: nitric oxide reductase activity
namespace: molecular_function
alt_id: GO:0016967
alt_id: GO:0016968
def: "Catalysis of the reaction: H(2)O + 2 ferricytochrome c + nitrous oxide = 2 H(+) + 2 ferrocytochrome c + 2 nitric oxide." [EC:1.7.2.5]
synonym: "CYP55" NARROW []
synonym: "cytochrome bc nitric oxide reductase activity" NARROW []
synonym: "nitric-oxide reductase activity" EXACT [EC:1.7.2.5]
synonym: "nitrogen oxide reductase activity" EXACT [EC:1.7.2.5]
synonym: "nitrous-oxide:(acceptor) oxidoreductase (NO-forming)" EXACT [EC:1.7.2.5]
synonym: "nitrous-oxide:acceptor oxidoreductase (NO-forming)" EXACT [EC:1.7.2.5]
synonym: "P450 nitric oxide reductase activity" NARROW []
synonym: "P450nor" NARROW []
xref: EC:1.7.2.5
xref: KEGG:R00294
xref: MetaCyc:NITRIC-OXIDE-REDUCTASE-RXN
is_a: GO:0016662 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor

[Term]
id: GO:0016969
name: obsolete hemerythrin
namespace: molecular_function
def: "OBSOLETE. An oxygen carrier found in a few groups of invertebrates, e.g. sipunculid worms, certain molluscs, and crustaceans." [GOC:ai, ISBN:0198506732]
comment: This term was made obsolete because it represents a gene product.
synonym: "hemerythrin" EXACT []
is_obsolete: true
replaced_by: GO:0005344

[Term]
id: GO:0016970
name: obsolete hemocyanin
namespace: molecular_function
def: "OBSOLETE. A blue, copper-containing oxygen carrier present in many molluscs and arthropods." [GOC:ai, ISBN:0198506732]
comment: This term was made obsolete because it represents a gene product.
synonym: "hemocyanin" EXACT []
is_obsolete: true
replaced_by: GO:0005344

[Term]
id: GO:0016971
name: flavin-linked sulfhydryl oxidase activity
namespace: molecular_function
def: "Catalysis of the formation of disulfide bridges." [PMID:10899311]
is_a: GO:0016972 ! thiol oxidase activity

[Term]
id: GO:0016972
name: thiol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4 R'C(R)SH + O2 = 2 R'C(R)S-S(R)CR' + 2 H2O." [EC:1.8.3.2]
synonym: "sulfhydryl oxidase activity" EXACT [EC:1.8.3.2]
synonym: "thiol:oxygen oxidoreductase activity" EXACT [EC:1.8.3.2]
xref: EC:1.8.3.2
xref: MetaCyc:THIOL-OXIDASE-RXN
xref: RHEA:17360
xref: UM-BBD_reactionID:r1293
is_a: GO:0016670 ! oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor

[Term]
id: GO:0016973
name: poly(A)+ mRNA export from nucleus
namespace: biological_process
def: "The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm." [GOC:ai]
synonym: "poly(A) mRNA export from nucleus" EXACT []
synonym: "poly(A)+ mRNA export from cell nucleus" EXACT []
synonym: "poly(A)+ mRNA export out of nucleus" EXACT []
synonym: "poly(A)+ mRNA transport from nucleus to cytoplasm" EXACT []
synonym: "poly(A)+ mRNA-nucleus export" EXACT []
synonym: "polyadenylated mRNA export from nucleus" RELATED []
is_a: GO:0006406 ! mRNA export from nucleus
is_a: GO:1902582 ! single-organism intracellular transport

[Term]
id: GO:0016975
name: obsolete alpha-2 macroglobulin
namespace: molecular_function
def: "OBSOLETE. Inhibition of proteinase by a mechanism involving a bait region which contains specific sites, cleavage of which induces a conformational change that results in trapping of the proteinase; following cleavage in the bait region a thiolester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase; subsequently epsilon-amino groups of the proteinase react with thiolester linkages in the inhibitor to form stable amide links; the entrapped proteinase can now only act on low molecular mass substrates." [ISBN:0198547684]
comment: This term was made obsolete because it represents a gene product.
synonym: "alpha-2 macroglobulin" EXACT []
is_obsolete: true
replaced_by: GO:0004866

[Term]
id: GO:0016977
name: chitosanase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of beta-1,4-linkages between N-acetyl-D-glucosamine and D-glucosamine residues in a partly acetylated chitosan." [EC:3.2.1.132]
subset: gosubset_prok
synonym: "chitosan N-acetylglucosaminohydrolase activity" EXACT [EC:3.2.1.132]
xref: EC:3.2.1.132
xref: MetaCyc:3.2.1.132-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0016979
name: lipoate-protein ligase activity
namespace: molecular_function
alt_id: GO:0008916
alt_id: GO:0016978
def: "Catalysis of the formation of carbon-nitrogen bonds between lipoate (5-(1,2-dithiolan-3-yl)pentanoate) and a protein." [EC:6.3.4.-]
subset: gosubset_prok
synonym: "lipoate-protein ligase A activity" NARROW []
synonym: "lipoate-protein ligase B activity" NARROW []
xref: EC:6.3.4.-
xref: MetaCyc:RXN-8654
xref: MetaCyc:RXN-8655
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0016980
name: creatinase activity
namespace: molecular_function
def: "Catalysis of the reaction: creatine + H(2)O = sarcosine + urea." [EC:3.5.3.3, RHEA:22459]
subset: gosubset_prok
synonym: "creatine amidinohydrolase activity" EXACT [EC:3.5.3.3]
xref: EC:3.5.3.3
xref: KEGG:R01566
xref: MetaCyc:CREATINASE-RXN
xref: RHEA:22459
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0016984
name: ribulose-bisphosphate carboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-ribulose 1,5-bisphosphate + CO2 + H2O = 2 3-phospho-D-glycerate." [EC:4.1.1.39]
subset: gosubset_prok
synonym: "3-phospho-D-glycerate carboxy-lyase (dimerizing)" EXACT [EC:4.1.1.39]
synonym: "3-phospho-D-glycerate carboxy-lyase (dimerizing; D-ribulose-1,5-bisphosphate-forming)" EXACT [EC:4.1.1.39]
synonym: "carboxydismutase activity" RELATED [EC:4.1.1.39]
synonym: "D-ribulose 1,5-diphosphate carboxylase activity" EXACT [EC:4.1.1.39]
synonym: "D-ribulose-1,5-bisphosphate carboxylase activity" EXACT [EC:4.1.1.39]
synonym: "diphosphoribulose carboxylase activity" EXACT [EC:4.1.1.39]
synonym: "ribulose 1,5-bisphosphate carboxylase activity" EXACT [EC:4.1.1.39]
synonym: "ribulose 1,5-bisphosphate carboxylase/oxygenase activity" EXACT []
synonym: "ribulose 1,5-diphosphate carboxylase activity" EXACT [EC:4.1.1.39]
synonym: "ribulose 1,5-diphosphate carboxylase/oxygenase activity" EXACT [EC:4.1.1.39]
synonym: "ribulose bisphosphate carboxylase/oxygenase activity" EXACT [EC:4.1.1.39]
synonym: "ribulose diphosphate carboxylase activity" EXACT [EC:4.1.1.39]
synonym: "ribulose diphosphate carboxylase/oxygenase activity" EXACT [EC:4.1.1.39]
synonym: "RuBisCO activity" EXACT [EC:4.1.1.39]
synonym: "rubisco activity" EXACT []
synonym: "RuBP carboxylase activity" EXACT [EC:4.1.1.39]
xref: EC:4.1.1.39
xref: MetaCyc:RIBULOSE-BISPHOSPHATE-CARBOXYLASE-RXN
xref: RHEA:23127
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0016985
name: mannan endo-1,4-beta-mannosidase activity
namespace: molecular_function
def: "Catalysis of the random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans, galactomannans, glucomannans, and galactoglucomannans." [EC:3.2.1.78]
subset: gosubset_prok
synonym: "1,4-beta-D-mannan mannanohydrolase activity" EXACT [EC:3.2.1.78]
synonym: "beta-1,4-mannan 4-mannanohydrolase activity" EXACT [EC:3.2.1.78]
synonym: "beta-D-mannanase activity" EXACT [EC:3.2.1.78]
synonym: "beta-mannanase activity" BROAD [EC:3.2.1.78]
synonym: "beta-mannanase B" RELATED [EC:3.2.1.78]
synonym: "endo-1,4-beta-mannanase activity" EXACT [EC:3.2.1.78]
synonym: "endo-1,4-mannanase activity" BROAD [EC:3.2.1.78]
synonym: "endo-beta-1,4-mannase activity" EXACT [EC:3.2.1.78]
synonym: "endo-beta-mannanase activity" BROAD [EC:3.2.1.78]
xref: EC:3.2.1.78
xref: MetaCyc:3.2.1.78-RXN
is_a: GO:0004567 ! beta-mannosidase activity

[Term]
id: GO:0016986
name: obsolete transcription initiation factor activity
namespace: molecular_function
def: "OBSOLETE. Plays a role in regulating transcription initiation." [GOC:curators]
comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
subset: gosubset_prok
synonym: "transcription initiation factor activity" EXACT []
synonym: "transcriptional initiation factor activity" EXACT []
is_obsolete: true
consider: GO:0000988
consider: GO:0000996
consider: GO:0001071
consider: GO:0006352

[Term]
id: GO:0016987
name: sigma factor activity
namespace: molecular_function
def: "A sigma factor is the promoter specificity subunit of eubacterial-type multisubunit RNA polymerases, those whose core subunit composition is often described as alpha(2)-beta-beta-prime. (This type of multisubunit RNA polymerase complex is known to be found in eubacteria and plant plastids). Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, this binds specifically to promoter sequences, with the sigma factor making sequence specific contacts with the promoter elements. The sigma subunit is released from the elongating form of the polymerase and is thus free to act catalytically for multiple RNA polymerase core enzymes." [GOC:krc, GOC:txnOH]
subset: gosubset_prok
synonym: "sigma transcription factor" RELATED []
is_a: GO:0000996 ! core DNA-dependent RNA polymerase binding promoter specificity activity
relationship: has_part GO:0000985 ! bacterial-type RNA polymerase core promoter sequence-specific DNA binding
relationship: has_part GO:0001000 ! bacterial-type RNA polymerase core enzyme binding

[Term]
id: GO:0016988
name: obsolete transcription initiation factor antagonist activity
namespace: molecular_function
def: "OBSOLETE. The function of binding to a transcription factor and stopping, preventing or reducing the rate of its transcriptional activity." [GOC:jl]
comment: This term was obsoleted because its definition was vague and apparently broader in scope than the name of the term suggested it was intended to be.
subset: gosubset_prok
synonym: "transcription initiation factor antagonist activity" EXACT []
synonym: "transcriptional initiation factor antagonist activity" EXACT []
is_obsolete: true

[Term]
id: GO:0016989
name: sigma factor antagonist activity
namespace: molecular_function
def: "The function of binding to a sigma factor and stopping, preventing or reducing the rate of its transcriptional activity." [GOC:jl, GOC:txnOH, Wikipedia:Anti-sigma_factors]
subset: gosubset_prok
synonym: "anti-sigma factor activity" EXACT []
is_a: GO:0000989 ! transcription factor activity, transcription factor binding

[Term]
id: GO:0016990
name: arginine deiminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arginine + H2O = L-citrulline + NH3." [EC:3.5.3.6]
subset: gosubset_prok
synonym: "arginine dihydrolase activity" EXACT [EC:3.5.3.6]
synonym: "citrulline iminase activity" EXACT [EC:3.5.3.6]
synonym: "L-arginine deiminase activity" EXACT [EC:3.5.3.6]
synonym: "L-arginine iminohydrolase activity" EXACT [EC:3.5.3.6]
xref: EC:3.5.3.6
xref: MetaCyc:ARGININE-DEIMINASE-RXN
xref: RHEA:19600
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
relationship: part_of GO:0018101 ! protein citrullination

[Term]
id: GO:0016992
name: lipoate synthase activity
namespace: molecular_function
alt_id: GO:0017140
def: "Catalysis of the reaction: protein N6-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosyl." [EC:2.8.1.8, PMID:18307109]
subset: gosubset_prok
synonym: "LipA" RELATED [EC:2.8.1.8]
synonym: "lipoic acid synthase" EXACT [GOC:dph, GOC:tb]
synonym: "lipoyl synthase activity" EXACT [EC:2.8.1.8]
synonym: "LS" RELATED [EC:2.8.1.8]
synonym: "protein 6-N-(octanoyl)lysine:sulfur sulfurtransferase activity" EXACT [EC:2.8.1.8]
synonym: "protein N6-(octanoyl)lysine:sulfur sulfurtransferase activity" EXACT [EC:2.8.1.8]
xref: EC:2.8.1.8
xref: MetaCyc:RXN0-949
is_a: GO:0016783 ! sulfurtransferase activity
is_a: GO:0016979 ! lipoate-protein ligase activity
is_a: GO:0070283 ! radical SAM enzyme activity
relationship: part_of GO:0009107 ! lipoate biosynthetic process

[Term]
id: GO:0016993
name: precorrin-8X methylmutase activity
namespace: molecular_function
def: "Catalysis of the reaction: precorrin-8X = hydrogenobyrinate." [EC:5.4.1.2]
subset: gosubset_prok
synonym: "HBA synthase activity" EXACT [EC:5.4.1.2]
synonym: "hydrogenobyrinic acid-binding protein activity" NARROW [EC:5.4.1.2]
synonym: "precorrin isomerase activity" EXACT [EC:5.4.1.2]
synonym: "precorrin-8X 11,12-methylmutase activity" EXACT [EC:5.4.1.2]
xref: EC:5.4.1.2
xref: MetaCyc:5.4.1.2-RXN
xref: RHEA:22515
is_a: GO:0016867 ! intramolecular transferase activity, transferring acyl groups

[Term]
id: GO:0016994
name: precorrin-6A reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: precorrin-6B + NADP+ = precorrin-6A + NADPH + H+." [EC:1.3.1.54]
subset: gosubset_prok
synonym: "precorrin-6B:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.54]
synonym: "precorrin-6X reductase activity" EXACT []
synonym: "precorrin-6Y:NADP(+) oxidoreductase activity" EXACT [EC:1.3.1.54]
synonym: "precorrin-6Y:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.54]
xref: EC:1.3.1.54
xref: MetaCyc:1.3.1.54-RXN
xref: RHEA:23411
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0016995
name: cholesterol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: cholesterol + O2 = cholest-5-en-3-one + H2O2." [EC:1.1.3.6, RHEA:21331]
synonym: "3beta-hydroxy steroid oxidoreductase activity" EXACT [EC:1.1.3.6]
synonym: "3beta-hydroxysteroid:oxygen oxidoreductase activity" EXACT [EC:1.1.3.6]
synonym: "cholesterol- O2 oxidoreductase activity" EXACT [EC:1.1.3.6]
synonym: "cholesterol-O(2) oxidoreductase activity" EXACT [EC:1.1.3.6]
synonym: "cholesterol-O2 oxidoreductase activity" EXACT [EC:1.1.3.6]
synonym: "cholesterol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.6]
xref: EC:1.1.3.6
xref: KEGG:R01459
xref: MetaCyc:CHOLESTEROL-OXIDASE-RXN
xref: RHEA:21331
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0016996
name: endo-alpha-(2,8)-sialidase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of (2->8)-alpha-sialosyl linkages in oligo- or poly(sialic) acids." [EC:3.2.1.129]
synonym: "alpha-2,8-sialosylhydrolase activity" EXACT [EC:3.2.1.129]
synonym: "endo-N-acetylneuraminidase activity" EXACT [EC:3.2.1.129]
synonym: "endo-N-acylneuraminidase activity" EXACT [EC:3.2.1.129]
synonym: "endoneuraminidase activity" EXACT [EC:3.2.1.129]
synonym: "endosialidase activity" EXACT [EC:3.2.1.129]
synonym: "poly(alpha-2,8-sialoside) alpha-2,8-sialosylhydrolase activity" EXACT [EC:3.2.1.129]
synonym: "poly(alpha-2,8-sialosyl) endo-N-acetylneuraminidase activity" EXACT [EC:3.2.1.129]
synonym: "polysialoside (2->8)-alpha-sialosylhydrolase activity" EXACT [EC:3.2.1.129]
xref: EC:3.2.1.129
xref: MetaCyc:3.2.1.129-RXN
is_a: GO:0016997 ! alpha-sialidase activity

[Term]
id: GO:0016997
name: alpha-sialidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of alpha-glycosidic linkages in oligo- or poly(sialic) acids." [GOC:mah]
subset: gosubset_prok
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0016998
name: cell wall macromolecule catabolic process
namespace: biological_process
alt_id: GO:0044039
def: "The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall." [GOC:go_curators]
subset: gosubset_prok
synonym: "cell wall breakdown" RELATED [GOC:mah]
synonym: "cell wall catabolism" RELATED [GOC:mah]
synonym: "cell wall degradation" RELATED [GOC:mah]
synonym: "cellular cell wall macromolecule breakdown" EXACT [GOC:mah]
synonym: "cellular cell wall macromolecule catabolic process" EXACT []
synonym: "cellular cell wall macromolecule catabolism" EXACT [GOC:mah]
synonym: "cellular cell wall macromolecule degradation" EXACT [GOC:mah]
is_a: GO:0044036 ! cell wall macromolecule metabolic process
is_a: GO:0044248 ! cellular catabolic process

[Term]
id: GO:0016999
name: antibiotic metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms." [GOC:cab2]
subset: gosubset_prok
synonym: "antibiotic metabolism" EXACT []
is_a: GO:0017144 ! drug metabolic process

[Term]
id: GO:0017000
name: antibiotic biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms." [GOC:go_curators]
subset: gosubset_prok
synonym: "antibiotic anabolism" EXACT []
synonym: "antibiotic biosynthesis" EXACT []
synonym: "antibiotic formation" EXACT []
synonym: "antibiotic synthesis" EXACT []
is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0017001
name: antibiotic catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms." [GOC:go_curators]
subset: gosubset_prok
synonym: "antibiotic breakdown" EXACT []
synonym: "antibiotic catabolism" EXACT []
synonym: "antibiotic degradation" EXACT []
is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0044248 ! cellular catabolic process

[Term]
id: GO:0017002
name: activin-activated receptor activity
namespace: molecular_function
def: "Combining with activin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Activin is one of two gonadal glycoproteins related to transforming growth factor beta." [GOC:mah, GOC:signaling, ISBN:0198506732]
comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand activin. For binding to other extracellular ligands, consider annotating to terms under 'transmembrane signaling receptor activity ; GO:0004888.
synonym: "activin receptor activity" EXACT [GOC:bf, GOC:signaling]
is_a: GO:0004675 ! transmembrane receptor protein serine/threonine kinase activity
relationship: has_part GO:0048185 ! activin binding
relationship: part_of GO:0032924 ! activin receptor signaling pathway

[Term]
id: GO:0017003
name: protein-heme linkage
namespace: biological_process
def: "The covalent linkage of heme and a protein." [GOC:ma]
subset: gosubset_prok
synonym: "protein-haem linkage" EXACT []
is_a: GO:0017006 ! protein-tetrapyrrole linkage

[Term]
id: GO:0017004
name: cytochrome complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions." [GOC:jl, GOC:mah]
subset: gosubset_prok
synonym: "cytochrome biogenesis" BROAD []
is_a: GO:0043623 ! cellular protein complex assembly

[Term]
id: GO:0017005
name: 3'-tyrosyl-DNA phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of 3'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase I and DNA." [PMID:10521354, PMID:16751265]
comment: See also the molecular function term 'DNA topoisomerase type I activity ; GO:0003917'.
is_a: GO:0070259 ! tyrosyl-DNA phosphodiesterase activity

[Term]
id: GO:0017006
name: protein-tetrapyrrole linkage
namespace: biological_process
def: "The covalent linking of a tetrapyrrole to a protein." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006464 ! cellular protein modification process

[Term]
id: GO:0017007
name: protein-bilin linkage
namespace: biological_process
def: "The covalent linkage of bilin and a protein." [GOC:ai]
subset: gosubset_prok
is_a: GO:0017006 ! protein-tetrapyrrole linkage

[Term]
id: GO:0017008
name: protein-phycobiliviolin linkage
namespace: biological_process
def: "The linkage of the chromophore phycobiliviolin to phycoerythrocyanin." [RESID:AA0258]
subset: gosubset_prok
xref: RESID:AA0258
is_a: GO:0017007 ! protein-bilin linkage

[Term]
id: GO:0017009
name: protein-phycocyanobilin linkage
namespace: biological_process
def: "The linkage of the chromophore phycocyanobilin to phycocyanin or allophycocyanin." [RESID:AA0131]
subset: gosubset_prok
xref: RESID:AA0131
is_a: GO:0017007 ! protein-bilin linkage

[Term]
id: GO:0017010
name: protein-phycourobilin linkage
namespace: biological_process
def: "The linkage of the chromophore phycourobilin to phycoerythrins." [RESID:AA0260]
subset: gosubset_prok
xref: RESID:AA0260
is_a: GO:0017007 ! protein-bilin linkage

[Term]
id: GO:0017011
name: protein-phycoerythrobilin linkage
namespace: biological_process
def: "The linkage of the chromophore phycoerythrobilin to phycoerythrins." [RESID:AA0132, RESID:AA0259]
subset: gosubset_prok
xref: RESID:AA0132
is_a: GO:0017007 ! protein-bilin linkage

[Term]
id: GO:0017012
name: protein-phytochromobilin linkage
namespace: biological_process
def: "The linkage of the chromophore phytochromobilin to phycocyanin or allophycocyanin." [RESID:AA0133]
subset: gosubset_prok
xref: RESID:AA0133
is_a: GO:0017007 ! protein-bilin linkage

[Term]
id: GO:0017013
name: protein flavinylation
namespace: biological_process
def: "The addition of a flavin group to a protein amino acid." [GOC:ai]
subset: gosubset_prok
synonym: "protein amino acid flavinylation" EXACT [GOC:bf]
is_a: GO:0006464 ! cellular protein modification process

[Term]
id: GO:0017014
name: protein nitrosylation
namespace: biological_process
def: "The covalent addition of a nitric oxide group to an amino acid within a protein." [GOC:ai, PMID:20972426]
subset: gosubset_prok
synonym: "protein amino acid nitrosylation" EXACT [GOC:bf]
is_a: GO:0006464 ! cellular protein modification process

[Term]
id: GO:0017015
name: regulation of transforming growth factor beta receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway." [GOC:mah]
synonym: "regulation of TGF-beta receptor signaling pathway" EXACT []
synonym: "regulation of TGFbeta receptor signaling pathway" EXACT []
synonym: "regulation of transforming growth factor beta receptor signalling pathway" EXACT []
is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
is_a: GO:1903844 ! regulation of cellular response to transforming growth factor beta stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007179 ! transforming growth factor beta receptor signaling pathway
relationship: regulates GO:0007179 ! transforming growth factor beta receptor signaling pathway

[Term]
id: GO:0017016
name: Ras GTPase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any member of the Ras superfamily of monomeric GTPases." [GOC:mah]
synonym: "Ras interactor activity" RELATED []
is_a: GO:0031267 ! small GTPase binding

[Term]
id: GO:0017017
name: MAP kinase tyrosine/serine/threonine phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate." [GOC:mah, PMID:12184814]
synonym: "dual-specificity MAP kinase phosphatase activity" EXACT []
xref: EC:3.1.3.-
is_a: GO:0008138 ! protein tyrosine/serine/threonine phosphatase activity
is_a: GO:0033549 ! MAP kinase phosphatase activity

[Term]
id: GO:0017018
name: myosin phosphatase activity
namespace: molecular_function
alt_id: GO:0017019
def: "Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate." [EC:3.1.3.16]
synonym: "myosin phosphatase myosin binding" RELATED []
synonym: "myosin phosphatase, intrinsic catalyst activity" EXACT []
xref: Reactome:REACT_100030 "ATP Hydrolysis By Myosin, Xenopus tropicalis"
xref: Reactome:REACT_100424 "ATP Hydrolysis By Myosin, Mus musculus"
xref: Reactome:REACT_101964 "ATP Hydrolysis By Myosin, Mus musculus"
xref: Reactome:REACT_103490 "ATP Hydrolysis By Myosin, Rattus norvegicus"
xref: Reactome:REACT_105566 "ATP Hydrolysis By Myosin, Sus scrofa"
xref: Reactome:REACT_105915 "ATP Hydrolysis By Myosin, Taeniopygia guttata"
xref: Reactome:REACT_107588 "ATP Hydrolysis By Myosin, Gallus gallus"
xref: Reactome:REACT_108134 "ATP Hydrolysis By Myosin, Bos taurus"
xref: Reactome:REACT_16995 "ATP Hydrolysis By Myosin, Homo sapiens"
xref: Reactome:REACT_20548 "ATP Hydrolysis By Myosin, Homo sapiens"
xref: Reactome:REACT_29871 "ATP Hydrolysis By Myosin, Xenopus tropicalis"
xref: Reactome:REACT_31749 "ATP Hydrolysis By Myosin, Taeniopygia guttata"
xref: Reactome:REACT_81063 "ATP Hydrolysis By Myosin, Danio rerio"
xref: Reactome:REACT_83303 "ATP Hydrolysis By Myosin, Gallus gallus"
xref: Reactome:REACT_85234 "ATP Hydrolysis By Myosin, Canis familiaris"
xref: Reactome:REACT_85875 "ATP Hydrolysis By Myosin, Rattus norvegicus"
xref: Reactome:REACT_92826 "ATP Hydrolysis By Myosin, Canis familiaris"
xref: Reactome:REACT_93990 "ATP Hydrolysis By Myosin, Bos taurus"
xref: Reactome:REACT_98654 "ATP Hydrolysis By Myosin, Danio rerio"
is_a: GO:0004722 ! protein serine/threonine phosphatase activity

[Term]
id: GO:0017020
name: myosin phosphatase regulator activity
namespace: molecular_function
def: "Modulation of the activity of the enzyme myosin phosphatase." [EC:3.1.3.16, GOC:ai]
synonym: "myosin phosphatase, intrinsic regulator activity" NARROW []
is_a: GO:0019888 ! protein phosphatase regulator activity
relationship: regulates GO:0017018 ! myosin phosphatase activity

[Term]
id: GO:0017021
name: obsolete myosin phosphatase myosin binding
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it describes the binding of myosin phosphatase to myosin, which is not a molecular function.
synonym: "myosin phosphatase myosin binding" EXACT []
is_obsolete: true
consider: GO:0017018
consider: GO:0017022

[Term]
id: GO:0017022
name: myosin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
synonym: "myosin phosphatase myosin binding" NARROW []
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0017023
name: myosin phosphatase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the removal of the phosphate group from phosphomyosin." [EC:3.1.3.16]
is_a: GO:0008287 ! protein serine/threonine phosphatase complex

[Term]
id: GO:0017024
name: myosin I binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a class I myosin; myosin I heavy chains are single-headed, possess tails of various lengths, and do not self-associate into bipolar filaments." [GOC:bf, GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
is_a: GO:0017022 ! myosin binding

[Term]
id: GO:0017025
name: TBP-class protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs)." [GOC:jl, GOC:txnOH, http://www.mblab.gla.ac.uk/, PMID:16858867]
synonym: "TATA-binding protein binding" NARROW []
synonym: "TBP binding" NARROW []
synonym: "TBP-related factor (TRF) protein binding" NARROW []
is_a: GO:0008134 ! transcription factor binding

[Term]
id: GO:0017026
name: obsolete procollagen C-endopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of the C-terminal propeptide at Ala-Asp in type I and II procollagens and at Arg-Asp in type III." [EC:3.4.24.19]
comment: This term was made obsolete because it represents a gene product.
synonym: "BMP1" NARROW []
synonym: "carboxyprocollagen peptidase activity" EXACT [EC:3.4.24.19]
synonym: "procollagen C-endopeptidase activity" EXACT []
synonym: "procollagen C-proteinase activity" EXACT [EC:3.4.24.19]
synonym: "procollagen C-terminal peptidase activity" EXACT [EC:3.4.24.19]
synonym: "procollagen C-terminal proteinase activity" EXACT [EC:3.4.24.19]
synonym: "procollagen carboxy-terminal proteinase activity" EXACT [EC:3.4.24.19]
synonym: "procollagen carboxypeptidase activity" EXACT [EC:3.4.24.19]
synonym: "procollagen peptidase activity" EXACT [EC:3.4.24.19]
xref: EC:3.4.24.19
xref: MetaCyc:3.4.24.19-RXN
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0017027
name: obsolete transmembrane receptor protein serine/threonine kinase receptor-associated protein activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product and not a molecular function.
synonym: "transmembrane receptor protein serine/threonine kinase receptor-associated protein activity" EXACT []
is_obsolete: true
consider: GO:0005102
consider: GO:0005515

[Term]
id: GO:0017028
name: obsolete protein stabilization activity
namespace: molecular_function
def: "OBSOLETE. Strengthening of a bond between proteins. Proteins are large molecules composed of one or more chains of amino acids. The amino acids are joined in a specific order by peptide bonds." [GOC:jid, http://biotech.icmb.utexas.edu]
comment: This term was made obsolete because it represents a biological process.
synonym: "protein stabilization activity" EXACT []
is_obsolete: true
replaced_by: GO:0050821

[Term]
id: GO:0017029
name: obsolete lysosomal protein stabilization
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it contains both component and function information.
synonym: "lysosomal protein stabilization" EXACT []
is_obsolete: true
consider: GO:0005764
consider: GO:0050821

[Term]
id: GO:0017030
name: obsolete beta-galactosidase stabilization activity
namespace: molecular_function
def: "OBSOLETE. Stabilization of the structure of beta-galactosidase." [GOC:ai]
comment: This term was made obsolete because it represents a biological process.
synonym: "beta-galactosidase stabilization activity" EXACT []
is_obsolete: true
replaced_by: GO:0050821

[Term]
id: GO:0017032
name: potassium:amino acid symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + K+(out) = amino acid(in) + K+(in)." [GOC:ai]
synonym: "potassium:amino acid transporter activity" BROAD []
is_a: GO:0005416 ! cation:amino acid symporter activity
is_a: GO:0022820 ! potassium ion symporter activity

[Term]
id: GO:0017034
name: Rap guanyl-nucleotide exchange factor activity
namespace: molecular_function
def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rap family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
is_a: GO:0005088 ! Ras guanyl-nucleotide exchange factor activity

[Term]
id: GO:0017038
name: protein import
namespace: biological_process
def: "The targeting and directed movement of proteins into a cell or organelle.  Not all import involves an initial targeting event." [GOC:ai]
subset: gosubset_prok
synonym: "protein uptake" EXACT []
is_a: GO:0015031 ! protein transport
is_a: GO:0044765 ! single-organism transport

[Term]
id: GO:0017039
name: obsolete dipeptidyl-peptidase III activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity; also acts on dipeptidyl 2-naphthylamides." [EC:3.4.14.4]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "dipeptidyl aminopeptidase III activity" EXACT [EC:3.4.14.4]
synonym: "dipeptidyl arylamidase III activity" EXACT [EC:3.4.14.4]
synonym: "dipeptidyl-peptidase III activity" EXACT []
synonym: "DPP III activity" EXACT [EC:3.4.14.4]
synonym: "enkephalinase B activity" NARROW [EC:3.4.14.4]
synonym: "red cell angiotensinase activity" NARROW [EC:3.4.14.4]
xref: EC:3.4.14.4
xref: MetaCyc:3.4.14.4-RXN
is_obsolete: true
replaced_by: GO:0008239

[Term]
id: GO:0017040
name: ceramidase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acylsphingosine + H2O = a fatty acid + sphingosine." [EC:3.5.1.23]
subset: gosubset_prok
synonym: "acylsphingosine deacylase activity" EXACT [EC:3.5.1.23]
synonym: "glycosphingolipid ceramide deacylase" BROAD [EC:3.5.1.23]
synonym: "N-acylsphingosine amidohydrolase activity" EXACT [EC:3.5.1.23]
xref: EC:3.5.1.23
xref: MetaCyc:CERAMIDASE-RXN
xref: Reactome:REACT_101573 "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum], Caenorhabditis elegans"
xref: Reactome:REACT_103385 "ceramide + H2O => stearate + sphingosine [Golgi], Bos taurus"
xref: Reactome:REACT_104156 "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum], Mus musculus"
xref: Reactome:REACT_108015 "ceramide + H2O => stearate + sphingosine [Golgi], Danio rerio"
xref: Reactome:REACT_109404 "ceramide + H2O => stearate + sphingosine [Golgi], Gallus gallus"
xref: Reactome:REACT_109901 "ceramide + H2O => stearate + sphingosine [Golgi], Sus scrofa"
xref: Reactome:REACT_112340 "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum], Arabidopsis thaliana"
xref: Reactome:REACT_112467 "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum], Oryza sativa"
xref: Reactome:REACT_113330 "ceramide + H2O => stearate + sphingosine [Golgi], Dictyostelium discoideum"
xref: Reactome:REACT_113430 "ceramide + H2O => stearate + sphingosine [Golgi], Oryza sativa"
xref: Reactome:REACT_114429 "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum], Dictyostelium discoideum"
xref: Reactome:REACT_115217 "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum], Drosophila melanogaster"
xref: Reactome:REACT_115458 "ceramide + H2O => stearate + sphingosine [Golgi], Arabidopsis thaliana"
xref: Reactome:REACT_115678 "ceramide + H2O => stearate + sphingosine [endoplasmic reticulum], Gallus gallus"
xref: Reactome:REACT_115894 "Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane), Homo sapiens"
xref: Reactome:REACT_115911 "Acid ceramidase hydrolyses ceramide into sphingosine and free fatty acid (lysosome), Homo sapiens"
xref: Reactome:REACT_19174 "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum], Homo sapiens"
xref: Reactome:REACT_19413 "ceramide + H2O => stearate + sphingosine [Golgi], Homo sapiens"
xref: Reactome:REACT_31319 "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum], Danio rerio"
xref: Reactome:REACT_31440 "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum], Xenopus tropicalis"
xref: Reactome:REACT_33364 "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum], Bos taurus"
xref: Reactome:REACT_82997 "ceramide + H2O => stearate + sphingosine [Golgi], Drosophila melanogaster"
xref: Reactome:REACT_86731 "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum], Gallus gallus"
xref: Reactome:REACT_91100 "ceramide + H2O => stearate + sphingosine [Golgi], Rattus norvegicus"
xref: Reactome:REACT_91642 "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum], Taeniopygia guttata"
xref: Reactome:REACT_91987 "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum], Canis familiaris"
xref: Reactome:REACT_92927 "ceramide + H2O => stearate + sphingosine [Golgi], Xenopus tropicalis"
xref: Reactome:REACT_93949 "ceramide + H2O => stearate + sphingosine [Golgi], Canis familiaris"
xref: Reactome:REACT_97011 "ceramide + H2O => stearate + sphingosine [Golgi], Mus musculus"
xref: Reactome:REACT_99632 "ceramide + H2O => stearate + sphingosine [Golgi], Caenorhabditis elegans"
xref: RHEA:20859
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0017041
name: galactosylgalactosylglucosylceramidase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine + H2O = lactosyl-N-acylsphingosine + D-galactose." [EC:3.2.1.47]
synonym: "ceramide trihexosidase activity" EXACT [EC:3.2.1.47]
synonym: "ceramidetrihexosidase activity" EXACT [EC:3.2.1.47]
synonym: "ceramidetrihexoside alpha-galactosidase activity" EXACT [EC:3.2.1.47]
synonym: "D-galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine galactohydrolase activity" EXACT [EC:3.2.1.47]
synonym: "trihexosyl ceramide galactosidase activity" EXACT [EC:3.2.1.47]
synonym: "trihexosylceramide alpha-galactosidase activity" EXACT [EC:3.2.1.47]
xref: EC:3.2.1.47
xref: MetaCyc:3.2.1.47-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0017042
name: glycosylceramidase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycosyl-N-acylsphingosine + H2O = a sugar + N-acylsphingosine." [EC:3.2.1.62]
synonym: "cerebrosidase activity" EXACT [EC:3.2.1.62]
synonym: "glycosyl ceramide glycosylhydrolase activity" EXACT [EC:3.2.1.62]
synonym: "glycosyl-N-acylsphingosine glycohydrolase activity" EXACT [EC:3.2.1.62]
synonym: "lactase-phlorizin hydrolase" BROAD [EC:3.2.1.62]
synonym: "phloretin-glucosidase activity" EXACT [EC:3.2.1.62]
synonym: "phloridzin beta-glucosidase activity" EXACT [EC:3.2.1.62]
synonym: "phloridzin glucosidase activity" EXACT [EC:3.2.1.62]
synonym: "phlorizin hydrolase activity" EXACT [EC:3.2.1.62]
xref: EC:3.2.1.62
xref: MetaCyc:GLYCOSYLCERAMIDASE-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0017043
name: obsolete adrenocorticotropin
namespace: molecular_function
def: "OBSOLETE. A polypeptide hormone which stimulates the adrenal cortex to synthesize and secrete glucocorticoid hormones." [ISBN:0198506732]
comment: This term was made obsolete because it represents a gene product.
synonym: "adrenocorticotropin" EXACT []
synonym: "corticotropin" BROAD []
is_obsolete: true
consider: GO:0005102
consider: GO:0046886
consider: GO:0046887

[Term]
id: GO:0017044
name: melanocyte-stimulating hormone activity
namespace: molecular_function
def: "The action characteristic of melanocyte-stimulating hormone, any of three peptide hormones that are produced by the intermediate lobe of the pituitary gland and, upon receptor binding, cause dispersal of melanosomes in melanophores of poikilothermic vertebrates." [ISBN:0198506732]
synonym: "alpha-melanocyte stimulating hormone activity" NARROW [ISBN:0198506732]
synonym: "alpha-melanophore stimulating hormone activity" NARROW [ISBN:0198506732]
synonym: "melanocyte stimulating hormone activity" EXACT []
is_a: GO:0005179 ! hormone activity

[Term]
id: GO:0017045
name: corticotropin-releasing hormone activity
namespace: molecular_function
def: "The action characteristic of corticotropin-releasing hormone (CRH), any of a number of peptides released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, CRH increases the rate of corticotropin secretion by the anterior pituitary." [ISBN:0198506732]
synonym: "adrenocorticotropin-releasing hormone" EXACT []
xref: Wikipedia:Corticotropin-releasing_hormone
is_a: GO:0005179 ! hormone activity

[Term]
id: GO:0017046
name: peptide hormone binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any peptide with hormonal activity in animals." [GOC:jl, ISBN:0198506732]
synonym: "polypeptide hormone binding" EXACT []
is_a: GO:0042277 ! peptide binding
is_a: GO:0042562 ! hormone binding

[Term]
id: GO:0017048
name: Rho GTPase binding
namespace: molecular_function
alt_id: GO:0017031
def: "Interacting selectively and non-covalently with Rho protein, any member of the Rho subfamily of the Ras superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton." [ISBN:0198547684, PMID:12581856]
synonym: "Rho interactor activity" RELATED []
synonym: "Rhophilin" NARROW []
is_a: GO:0017016 ! Ras GTPase binding

[Term]
id: GO:0017049
name: GTP-Rho binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the GTP-bound form of the Rho protein." [GOC:mah]
is_a: GO:0017048 ! Rho GTPase binding

[Term]
id: GO:0017050
name: D-erythro-sphingosine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: sphingosine + ATP = sphingosine 1-phosphate + ADP." [MetaCyc:RXN3DJ-11417]
synonym: "sphingosine kinase activity" EXACT []
xref: MetaCyc:RXN3DJ-11417
xref: Reactome:REACT_104600 "sphingosine +ATP => sphingosine 1-phosphate + ADP, Rattus norvegicus"
xref: Reactome:REACT_109412 "sphingosine +ATP => sphingosine 1-phosphate + ADP, Canis familiaris"
xref: Reactome:REACT_109583 "sphingosine +ATP => sphingosine 1-phosphate + ADP, Arabidopsis thaliana"
xref: Reactome:REACT_114199 "sphingosine +ATP => sphingosine 1-phosphate + ADP, Caenorhabditis elegans"
xref: Reactome:REACT_19352 "sphingosine +ATP => sphingosine 1-phosphate + ADP, Homo sapiens"
xref: Reactome:REACT_29138 "sphingosine +ATP => sphingosine 1-phosphate + ADP, Xenopus tropicalis"
xref: Reactome:REACT_32769 "sphingosine +ATP => sphingosine 1-phosphate + ADP, Drosophila melanogaster"
xref: Reactome:REACT_34313 "sphingosine +ATP => sphingosine 1-phosphate + ADP, Bos taurus"
xref: Reactome:REACT_77369 "sphingosine +ATP => sphingosine 1-phosphate + ADP, Taeniopygia guttata"
xref: Reactome:REACT_78952 "sphingosine +ATP => sphingosine 1-phosphate + ADP, Gallus gallus"
xref: Reactome:REACT_79992 "sphingosine +ATP => sphingosine 1-phosphate + ADP, Schizosaccharomyces pombe"
xref: Reactome:REACT_83668 "sphingosine +ATP => sphingosine 1-phosphate + ADP, Dictyostelium discoideum"
xref: Reactome:REACT_83813 "sphingosine +ATP => sphingosine 1-phosphate + ADP, Sus scrofa"
xref: Reactome:REACT_86453 "sphingosine +ATP => sphingosine 1-phosphate + ADP, Danio rerio"
xref: Reactome:REACT_86835 "sphingosine +ATP => sphingosine 1-phosphate + ADP, Mus musculus"
xref: Reactome:REACT_87002 "sphingosine +ATP => sphingosine 1-phosphate + ADP, Saccharomyces cerevisiae"
xref: Reactome:REACT_88708 "sphingosine +ATP => sphingosine 1-phosphate + ADP, Oryza sativa"
is_a: GO:0016301 ! kinase activity

[Term]
id: GO:0017051
name: retinol dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + retinol = adenosine 3',5'-bisphosphate + anhydroretinol." [PMID:9857081]
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0017052
name: obsolete insulin-like growth factor binding protein
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "insulin-like growth factor binding protein" EXACT []
is_obsolete: true
consider: GO:0016942

[Term]
id: GO:0017053
name: transcriptional repressor complex
namespace: cellular_component
def: "A protein complex that possesses activity that prevents or downregulates transcription." [GOC:mah]
subset: goslim_pir
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0017054
name: negative cofactor 2 complex
namespace: cellular_component
def: "A heterodimeric protein complex that can stably associate with TATA-binding protein on promoters, thereby preventing the assembly of transcription factors TFIIA and TFIIB and leading to repression of RNA polymerase II transcription. The two subunits, NC2alpha (Drap1) and NC2beta (Dr1), dimerize through histone fold domains of the H2A/H2B type present in the amino termini." [PMID:15574413]
is_a: GO:0090571 ! RNA polymerase II transcription repressor complex

[Term]
id: GO:0017055
name: negative regulation of RNA polymerase II transcriptional preinitiation complex assembly
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly." [GOC:go_curators]
synonym: "down regulation of RNA polymerase II transcriptional preinitiation complex assembly" EXACT []
synonym: "down-regulation of RNA polymerase II transcriptional preinitiation complex assembly" EXACT []
synonym: "downregulation of RNA polymerase II transcriptional preinitiation complex assembly" EXACT []
synonym: "inhibition of RNA polymerase II transcriptional preinitiation complex assembly" NARROW []
synonym: "negative regulation of RNA polymerase II transcriptional pre-initiation complex assembly" EXACT []
synonym: "negative regulation of RNA polymerase II transcriptional pre-initiation complex biosynthesis" EXACT []
synonym: "negative regulation of RNA polymerase II transcriptional preinitiation complex formation" EXACT []
is_a: GO:0045898 ! regulation of RNA polymerase II transcriptional preinitiation complex assembly
is_a: GO:0060633 ! negative regulation of transcription initiation from RNA polymerase II promoter
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051123 ! RNA polymerase II transcriptional preinitiation complex assembly
relationship: negatively_regulates GO:0051123 ! RNA polymerase II transcriptional preinitiation complex assembly

[Term]
id: GO:0017056
name: structural constituent of nuclear pore
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of the nuclear pore complex." [GOC:mah]
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0017057
name: 6-phosphogluconolactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-O-phosphono-D-glucono-1,5-lactone + H(2)O = 6-phospho-D-gluconate + H(+)." [EC:3.1.1.31, RHEA:12559]
subset: gosubset_prok
synonym: "6-PGL" RELATED [EC:3.1.1.31]
synonym: "6-phospho-D-glucono-1,5-lactone lactonohydrolase activity" EXACT [EC:3.1.1.31]
synonym: "phosphogluconolactonase activity" EXACT [EC:3.1.1.31]
xref: EC:3.1.1.31
xref: KEGG:R02035
xref: MetaCyc:6PGLUCONOLACT-RXN
xref: Reactome:REACT_106780 "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate, Canis familiaris"
xref: Reactome:REACT_108830 "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate, Saccharomyces cerevisiae"
xref: Reactome:REACT_109818 "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate, Schizosaccharomyces pombe"
xref: Reactome:REACT_110192 "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate, Sus scrofa"
xref: Reactome:REACT_2072 "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate, Homo sapiens"
xref: Reactome:REACT_31251 "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate, Caenorhabditis elegans"
xref: Reactome:REACT_32786 "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate, Bos taurus"
xref: Reactome:REACT_32811 "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate, Oryza sativa"
xref: Reactome:REACT_34726 "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate, Danio rerio"
xref: Reactome:REACT_77170 "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate, Rattus norvegicus"
xref: Reactome:REACT_85480 "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate, Xenopus tropicalis"
xref: Reactome:REACT_87813 "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate, Arabidopsis thaliana"
xref: Reactome:REACT_89152 "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate, Mycobacterium tuberculosis"
xref: Reactome:REACT_94941 "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate, Dictyostelium discoideum"
xref: Reactome:REACT_96725 "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate, Mus musculus"
xref: Reactome:REACT_97561 "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate, Drosophila melanogaster"
xref: RHEA:12559
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0017058
name: FH1 domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a FH1 domain of a protein, a proline-rich domain, usually located in front of a FH2 domain." [GOC:go_curators]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0017059
name: serine C-palmitoyltransferase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the transfer of a palmitoyl on to serine, forming 3-dehydro-D-sphinganine." [EC:2.3.1.50]
is_a: GO:0031211 ! endoplasmic reticulum palmitoyltransferase complex

[Term]
id: GO:0017060
name: 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-(1,3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1,3)-[alpha-L-fucosyl-(1,4)]-N-acetyl-D-glucosaminyl-R." [EC:2.4.1.65]
synonym: "(Le(a))-dependent (alpha-3/4)-fucosyltransferase activity" BROAD [EC:2.4.1.65]
synonym: "(Lea)-dependent (alpha-3/4)-fucosyltransferase activity" BROAD [EC:2.4.1.65]
synonym: "3-alpha-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.65]
synonym: "alpha(1,4)-L-fucosyltransferase activity" BROAD []
synonym: "alpha-(1,3/1,4) fucosyltransferase III activity" BROAD [EC:2.4.1.65]
synonym: "alpha-(1,4)-L-fucosyltransferase activity" BROAD [EC:2.4.1.65]
synonym: "alpha-(1->4)-L-fucosyltransferase activity" BROAD [EC:2.4.1.65]
synonym: "alpha-4-L-fucosyltransferase activity" BROAD [EC:2.4.1.65]
synonym: "beta-acetylglucosaminylsaccharide fucosyltransferase activity" BROAD [EC:2.4.1.65]
synonym: "blood group Lewis alpha-4-fucosyltransferase activity" BROAD [EC:2.4.1.65]
synonym: "blood-group substance Le(a)-dependent fucosyltransferase activity" BROAD [EC:2.4.1.65]
synonym: "blood-group substance Lea-dependent fucosyltransferase" BROAD [EC:2.4.1.65]
synonym: "FucT-II activity" BROAD [EC:2.4.1.65]
synonym: "galactoside 3(4)-L-fucosyltransferase activity" BROAD []
synonym: "GDP-beta-L-fucose:3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 4I-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.65]
synonym: "GDP-L-fucose:3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 4I-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.65]
synonym: "guanosine diphosphofucose-beta-acetylglucosaminylsaccharide 4-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.65]
synonym: "guanosine diphosphofucose-glycoprotein 4-alpha-fucosyltransferase activity" EXACT [EC:2.4.1.65]
synonym: "guanosine diphosphofucose-glycoprotein 4-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.65]
synonym: "Lewis alpha-(1,3/4)-fucosyltransferase activity" BROAD [EC:2.4.1.65]
synonym: "Lewis alpha-(1->3/4)-fucosyltransferase activity" BROAD [EC:2.4.1.65]
synonym: "Lewis blood group alpha-(1,3/4)-fucosyltransferase activity" BROAD [EC:2.4.1.65]
synonym: "Lewis blood group alpha-(1->3/4)-fucosyltransferase activity" BROAD [EC:2.4.1.65]
synonym: "Lewis FT activity" BROAD [EC:2.4.1.65]
synonym: "Lewis(Le) blood group gene-dependent alpha-(1,3/4)-L-fucosyltransferase activity" BROAD []
synonym: "Lewis(Le) blood group gene-dependent alpha-(1->3/4)-L-fucosyltransferase activity" NARROW [EC:2.4.1.65]
xref: EC:2.4.1.65
xref: MetaCyc:2.4.1.65-RXN
xref: RHEA:23631
is_a: GO:0008417 ! fucosyltransferase activity

[Term]
id: GO:0017061
name: S-methyl-5-thioadenosine phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5'-methylthioadenosine + phosphate = adenine + 5-methylthio-D-ribose 1-phosphate." [EC:2.4.2.28]
subset: gosubset_prok
synonym: "5'-deoxy-5'-methylthioadenosine phosphorylase activity" EXACT [EC:2.4.2.28]
synonym: "5'-methylthioadenosine phosphorylase activity" EXACT []
synonym: "5'-methylthioadenosine:phosphate methylthio-D-ribosyl-transferase activity" EXACT [EC:2.4.2.28]
synonym: "MeSAdo phosphorylase activity" EXACT [EC:2.4.2.28]
synonym: "MeSAdo/Ado phosphorylase activity" EXACT [EC:2.4.2.28]
synonym: "methylthioadenosine nucleoside phosphorylase activity" EXACT [EC:2.4.2.28]
synonym: "methylthioadenosine phosphorylase activity" EXACT [EC:2.4.2.28]
synonym: "MTA phosphorylase activity" EXACT [EC:2.4.2.28]
synonym: "MTAPase activity" EXACT [EC:2.4.2.28]
synonym: "S-methyl-5-thioadenosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase activity" EXACT [EC:2.4.2.28]
xref: EC:2.4.2.28
xref: MetaCyc:5-METHYLTHIOADENOSINE-PHOSPHORYLASE-RXN
xref: Reactome:REACT_75786 "MTA is cleaved and phosphorylated, Homo sapiens"
is_a: GO:0004731 ! purine-nucleoside phosphorylase activity

[Term]
id: GO:0017062
name: respiratory chain complex III assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the cytochrome bc(1) complex, a transmembrane lipoprotein complex that it catalyzes the reduction of cytochrome c by accepting reducing equivalents from Coenzyme Q, by the aggregation, arrangement and bonding together of its constituents." [GOC:jl, http://www.brainyencyclopedia.com/]
subset: gosubset_prok
synonym: "coenzyme Q and cytochrome c reductase complex assembly" EXACT []
synonym: "coenzyme Q and cytochrome c reductase complex biogenesis" EXACT []
synonym: "complex III assembly" EXACT []
synonym: "complex III biogenesis" EXACT []
synonym: "cytochrome bc(1) complex assembly" EXACT [GOC:mcc]
synonym: "cytochrome bc(1) complex biogenesis" EXACT []
is_a: GO:0017004 ! cytochrome complex assembly

[Term]
id: GO:0017063
name: obsolete phosphatidylserine-specific phospholipase A1 activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.32]
comment: This term was made obsolete because the definition does not match the term name.
synonym: "phosphatidylserine-specific phospholipase A1 activity" EXACT []
is_obsolete: true
consider: GO:0052739
consider: GO:0052740

[Term]
id: GO:0017064
name: fatty acid amide hydrolase activity
namespace: molecular_function
alt_id: GO:0017073
def: "Catalysis of the hydrolysis of a fatty acid amide to yield a fatty acid." [PMID:15952893]
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0017065
name: single-strand selective uracil DNA N-glycosylase activity
namespace: molecular_function
def: "Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases present in single-stranded DNA." [GOC:elh, PMID:9224623]
synonym: "single-strand selective monofunctional uracil-DNA glycosylase activity" EXACT []
xref: EC:3.2.2.-
xref: Reactome:REACT_102611 "Cleavage of uracil by hSMUG1 glycosylase, Danio rerio"
xref: Reactome:REACT_104679 "Cleavage of uracil by hSMUG1 glycosylase, Sus scrofa"
xref: Reactome:REACT_107287 "Cleavage of uracil by hSMUG1 glycosylase, Mus musculus"
xref: Reactome:REACT_2205 "Cleavage of uracil by hSMUG1 glycosylase, Homo sapiens"
xref: Reactome:REACT_31054 "Cleavage of uracil by hSMUG1 glycosylase, Canis familiaris"
xref: Reactome:REACT_78083 "Cleavage of uracil by hSMUG1 glycosylase, Bos taurus"
xref: Reactome:REACT_81762 "Cleavage of uracil by hSMUG1 glycosylase, Gallus gallus"
xref: Reactome:REACT_83485 "Cleavage of uracil by hSMUG1 glycosylase, Xenopus tropicalis"
xref: Reactome:REACT_83639 "Cleavage of uracil by hSMUG1 glycosylase, Rattus norvegicus"
xref: Reactome:REACT_93821 "Cleavage of uracil by hSMUG1 glycosylase, Drosophila melanogaster"
is_a: GO:0004844 ! uracil DNA N-glycosylase activity

[Term]
id: GO:0017067
name: tyrosine-ester sulfotransferase activity
namespace: molecular_function
alt_id: GO:0008128
def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + L-tyrosine methyl ester = L-tyrosine methyl ester 4-sulfate + adenosine 3',5'-diphosphate + H(+)." [EC:2.8.2.9, RHEA:19980]
synonym: "3'-phosphoadenylyl-sulfate:L-tyrosine-methyl-ester sulfotransferase activity" EXACT [EC:2.8.2.9]
synonym: "aryl sulfotransferase IV" RELATED [EC:2.8.2.9]
synonym: "L-tyrosine methyl ester sulfotransferase activity" EXACT [EC:2.8.2.9]
synonym: "tyrosine-ester sulphotransferase activity" EXACT []
xref: EC:2.8.2.9
xref: KEGG:R04213
xref: MetaCyc:TYROSINE-ESTER-SULFOTRANSFERASE-RXN
xref: RHEA:19980
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0017069
name: snRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a small nuclear RNA (snRNA)." [GOC:mah]
synonym: "small nuclear RNA binding" EXACT []
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0017070
name: U6 snRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the U6 small nuclear RNA (U6 snRNA)." [GOC:mah]
comment: Note that this term may be useful for annotating small nuclear RNAs (snRNAs).
is_a: GO:0017069 ! snRNA binding

[Term]
id: GO:0017071
name: intracellular cyclic nucleotide activated cation channel complex
namespace: cellular_component
def: "A protein complex that forms a transmembrane channel through which cations ions may pass in response to an intracellular cyclic nucleotide binding to the channel complex or one of its constituent parts." [GOC:mah]
is_a: GO:0034703 ! cation channel complex
is_a: GO:0043235 ! receptor complex

[Term]
id: GO:0017072
name: obsolete tubulin-specific chaperone activity
namespace: molecular_function
def: "OBSOLETE. Assists in the correct, non-covalent assembly of tubulin-containing structures in vivo, but is not a component of the assembled structures when performing its normal biological function." [GOC:jl, PMID:11847227]
comment: This term was made obsolete because it represents a class of gene products and a biological process rather than a molecular function.
synonym: "tubulin-specific chaperone activity" EXACT []
is_obsolete: true
consider: GO:0006461
consider: GO:0007021
consider: GO:0044183
consider: GO:0051082

[Term]
id: GO:0017074
name: obsolete procollagen N-endopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of the N-propeptide of collagen chain alpha-1(I) at Pro-Gln and of alpha-1(II) and alpha-2(I) chains at Ala-Gln." [EC:3.4.24.14]
comment: This term was made obsolete because it represents a gene product.
synonym: "aminoprocollagen peptidase activity" EXACT [EC:3.4.24.14]
synonym: "aminoterminal procollagen peptidase activity" EXACT [EC:3.4.24.14]
synonym: "procollagen aminopeptidase activity" EXACT [EC:3.4.24.14]
synonym: "procollagen aminoterminal protease activity" EXACT [EC:3.4.24.14]
synonym: "procollagen N-endopeptidase activity" EXACT []
synonym: "procollagen N-proteinase activity" EXACT [EC:3.4.24.14]
synonym: "procollagen N-terminal peptidase activity" EXACT [EC:3.4.24.14]
synonym: "procollagen N-terminal proteinase activity" EXACT [EC:3.4.24.14]
synonym: "type I/II procollagen N-proteinase activity" EXACT [EC:3.4.24.14]
synonym: "type III procollagen" RELATED [EC:3.4.24.14]
xref: EC:3.4.24.14
xref: MetaCyc:3.4.24.14-RXN
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0017075
name: syntaxin-1 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the SNAP receptor syntaxin-1." [GOC:ai]
is_a: GO:0019905 ! syntaxin binding

[Term]
id: GO:0017076
name: purine nucleotide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with purine nucleotides, any compound consisting of a purine nucleoside esterified with (ortho)phosphate." [GOC:ai]
subset: gosubset_prok
is_a: GO:0000166 ! nucleotide binding

[Term]
id: GO:0017077
name: oxidative phosphorylation uncoupler activity
namespace: molecular_function
alt_id: GO:0015302
def: "Catalysis of the transfer of protons from mitochondrial intermembrane space into mitochondrial matrix, dissipating the proton gradient across the mitochondrial inner membrane established by the electron transport chain during the oxidative phosphorylation (proton leak). Proton leak uncouples the processes of electron transport/proton generation and ATP synthesis." [PMID:15738989, PMID:16179945]
synonym: "mitochondrial uncoupling protein activity" NARROW []
synonym: "uncoupling protein activity" NARROW []
is_a: GO:0022857 ! transmembrane transporter activity
relationship: part_of GO:0015992 ! proton transport

[Term]
id: GO:0017078
name: obsolete Hsc70 protein regulator activity
namespace: molecular_function
def: "OBSOLETE. Binds to and modulates the activity of the molecular chaperone Hsc70." [GOC:jl, PMID:11121403]
comment: This term was made obsolete because it refers to a non-existent molecular function term, 'Hsp70 protein activity'.
synonym: "Hsc70 interacting protein" BROAD []
synonym: "Hsc70 protein regulator activity" EXACT []
is_obsolete: true
replaced_by: GO:0031072
consider: GO:0006457
consider: GO:0051082
consider: GO:0051787

[Term]
id: GO:0017080
name: sodium channel regulator activity
namespace: molecular_function
def: "Modulates the activity of a sodium channel." [GOC:mah]
is_a: GO:0016247 ! channel regulator activity
relationship: regulates GO:0005272 ! sodium channel activity

[Term]
id: GO:0017081
name: chloride channel regulator activity
namespace: molecular_function
def: "Modulates the activity of a chloride channel." [GOC:mah]
xref: Reactome:REACT_100974 "HCO3- transport through ion channel, Gallus gallus"
xref: Reactome:REACT_101099 "HCO3- transport through ion channel, Canis familiaris"
xref: Reactome:REACT_103628 "HCO3- transport through ion channel, Taeniopygia guttata"
xref: Reactome:REACT_106223 "HCO3- transport through ion channel, Sus scrofa"
xref: Reactome:REACT_110502 "HCO3- transport through ion channel, Rattus norvegicus"
xref: Reactome:REACT_112601 "HCO3- transport through ion channel, Escherichia coli"
xref: Reactome:REACT_15300 "HCO3- transport through ion channel, Homo sapiens"
xref: Reactome:REACT_87091 "HCO3- transport through ion channel, Bos taurus"
xref: Reactome:REACT_91570 "HCO3- transport through ion channel, Xenopus tropicalis"
xref: Reactome:REACT_92427 "HCO3- transport through ion channel, Mus musculus"
xref: Reactome:REACT_95442 "HCO3- transport through ion channel, Danio rerio"
is_a: GO:0016247 ! channel regulator activity
relationship: regulates GO:0005254 ! chloride channel activity

[Term]
id: GO:0017082
name: mineralocorticoid receptor activity
namespace: molecular_function
def: "Combining with a mineralocorticoid and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II." [GOC:signaling, PMID:20932876]
synonym: "aldosterone receptor" NARROW []
is_a: GO:0003707 ! steroid hormone receptor activity
is_a: GO:0004879 ! RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
relationship: part_of GO:0031959 ! mineralocorticoid receptor signaling pathway

[Term]
id: GO:0017083
name: 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-beta-L-fucose + beta-D-galactosyl-(1,4)-N-acetyl-D-glucosaminyl-R = GDP + 1,4-beta-D-galactosyl-(1,4)-[alpha-L-fucosyl-(1,4)]-N-acetyl-D-glucosaminyl-R." [EC:2.4.1.152]
synonym: "galactoside 3-fucosyltransferase activity" EXACT [EC:2.4.1.152]
synonym: "galactoside 3-L-fucosyltransferase activity" EXACT []
synonym: "GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.152]
synonym: "GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-L-fucosyltransferase activity" EXACT [EC:2.4.1.152]
synonym: "GDP-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-L-fucosyltransferase activity" EXACT [EC:2.4.1.152]
synonym: "guanosine diphosphofucose-glucoside alpha-1->3-fucosyltransferase activity" EXACT [EC:2.4.1.152]
synonym: "guanosine diphosphofucose-glucoside alpha1->3-fucosyltransferase activity" EXACT [EC:2.4.1.152]
synonym: "Lewis-negative alpha-3-fucosyltransferase activity" NARROW [EC:2.4.1.152]
synonym: "lewis-negative alpha-3-fucosyltransferase activity" EXACT [EC:2.4.1.152]
synonym: "plasma alpha-3-fucosyltransferase activity" NARROW [EC:2.4.1.152]
xref: EC:2.4.1.152
xref: MetaCyc:GALACTOSIDE-3-FUCOSYLTRANSFERASE-RXN
is_a: GO:0046920 ! alpha-(1->3)-fucosyltransferase activity

[Term]
id: GO:0017084
name: delta1-pyrroline-5-carboxylate synthetase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamate + ATP + NADPH = ADP + L-glutamate gamma-semialdehyde + NADP+ + phosphate." [MetaCyc:PROLINE-MULTI]
synonym: "D1-pyrroline-5-carboxylate synthetase activity" EXACT []
xref: Reactome:REACT_21319 "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS], Homo sapiens"
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0017085
name: response to insecticide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects." [GOC:curators]
subset: gosubset_prok
synonym: "insecticide resistance" RELATED []
synonym: "insecticide susceptibility/resistance" RELATED []
is_a: GO:0009636 ! response to toxic substance

[Term]
id: GO:0017086
name: 3-methyl-2-oxobutanoate dehydrogenase (lipoamide) complex
namespace: cellular_component
alt_id: GO:0031212
def: "A protein complex that catalyzes the reaction 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)-dihydrolipoamide + carbon dioxide (CO2). This requires thiamine diphosphate; the enzyme also acts on (S)-3-methyl-2-oxopentanoate and 4-methyl-2-oxo-pentanoate." [EC:1.2.4.4]
synonym: "BCADH" EXACT []
synonym: "branched-chain alpha-ketoacid dehydrogenase complex" EXACT []
is_a: GO:0098798 ! mitochondrial protein complex
relationship: part_of GO:0005759 ! mitochondrial matrix

[Term]
id: GO:0017087
name: mitochondrial processing peptidase complex
namespace: cellular_component
def: "A protein complex that consists of a catalytic alpha subunit (alpha-MPP) and a regulatory beta subunit (beta-MPP), and catalyzes the release of N-terminal targeting peptides from precursor proteins imported into the mitochondrion." [BRENDA:3.4.24.64, EC:3.4.24.64, GOC:mah]
comment: Note that monomeric mitochondrial processing peptidases have been observed.
is_a: GO:0098798 ! mitochondrial protein complex
relationship: part_of GO:0005759 ! mitochondrial matrix

[Term]
id: GO:0017088
name: obsolete X-Pro dipeptidyl-peptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of the terminal bond of Xaa-Pro-Xaa motifs to release unblocked, N-terminal dipeptides from substrates including Ala-Pro-para-nitroanilide and (sequentially, at the second, fourth and sixth bonds) of the motif Tyr-Pro-Phe-Pro-Gly-Pro-Ile." [EC:3.4.14.11]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "PepX" RELATED [EC:3.4.14.11]
synonym: "X-Pro dipeptidyl-peptidase activity" EXACT []
synonym: "X-prolyl dipeptidyl aminopeptidase activity" EXACT [EC:3.4.14.11]
synonym: "X-prolyl dipeptidyl peptidase activity" EXACT [EC:3.4.14.11]
synonym: "Xaa-Pro dipeptidyl-peptidase activity" EXACT []
xref: EC:3.4.14.11
xref: MetaCyc:3.4.14.11-RXN
is_obsolete: true
replaced_by: GO:0008239

[Term]
id: GO:0017089
name: glycolipid transporter activity
namespace: molecular_function
def: "Enables the directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of or within a cell, or between cells." [GOC:ai]
is_a: GO:0005319 ! lipid transporter activity
is_a: GO:1901505 ! carbohydrate derivative transporter activity
relationship: part_of GO:0046836 ! glycolipid transport

[Term]
id: GO:0017090
name: meprin A complex
namespace: cellular_component
def: "A protein complex that is located in the cell membrane, and is involved in the metabolism of peptides, including neuropeptides. The complex has metalloendopeptidase activity that catalyzes the hydrolysis of protein and peptide substrates, preferentially on carboxyl side of hydrophobic residues." [EC:3.4.24.18, GOC:mah, MEROPS_fam:M12]
synonym: "PABA peptide hydrolase complex" EXACT []
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0016021 ! integral component of membrane

[Term]
id: GO:0017091
name: AU-rich element binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a region of RNA containing frequent adenine and uridine bases." [GOC:bf, GOC:mah, PMID:7892223, PMID:8578590]
synonym: "Adenylate/uridylate-rich element binding" EXACT [PMID:8578590]
synonym: "ARE binding" EXACT []
synonym: "AU-specific RNA binding" EXACT []
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0017092
name: obsolete sterol regulatory element-binding protein site 2 protease activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage, within the membrane-spanning helix, of the amino-terminal half (the intermediate form) of sterol regulatory element binding protein (SREBP). This activity releases the transcription factor domain of SREBP from the membrane, freeing it to enter the nucleus." [GOC:bf, PMID:12923525]
comment: This term was made obsolete because it represents a gene product.
synonym: "SREBP site 2 protease activity" EXACT []
synonym: "sterol regulatory element-binding protein site 2 protease activity" EXACT []
is_obsolete: true
replaced_by: GO:0008237

[Term]
id: GO:0017093
name: obsolete sterol regulatory element-binding protein protease activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds within a sterol regulatory element binding protein (SREBP). SREBPs are transcription factors that bind sterol regulatory elements (SREs), DNA motifs found in the promoters of target genes." [GOC:bf, PMID:12923525]
comment: This term was made obsolete because it represents a gene product.
synonym: "SREBP protease activity" EXACT []
synonym: "sterol regulatory element-binding protein protease activity" EXACT []
is_obsolete: true
replaced_by: GO:0070011

[Term]
id: GO:0017094
name: obsolete sterol regulatory element-binding protein site 1 protease activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of a Leu-Ser bond within the luminal loop of a sterol regulatory element binding protein (SREBP). This activity is the first of two sequential cleavage reactions and cleaves SREBP into two membrane-bound halves." [GOC:bf, PMID:12923525]
comment: This term was made obsolete because it represents a gene product.
synonym: "SREBP site 1 protease activity" EXACT []
synonym: "sterol regulatory element-binding protein site 1 protease activity" EXACT []
is_obsolete: true
replaced_by: GO:0008236

[Term]
id: GO:0017095
name: heparan sulfate 6-O-sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 6-O-sulfate; results in 6-O-sulfation of glucosamine residues in heparan sulfate." [PMID:8631808]
synonym: "heparan sulphate 6-O-sulphotransferase activity" EXACT []
synonym: "heparin 6-O-sulfotransferase activity" RELATED []
xref: EC:2.8.2.-
is_a: GO:0034483 ! heparan sulfate sulfotransferase activity

[Term]
id: GO:0017096
name: acetylserotonin O-methyltransferase activity
namespace: molecular_function
alt_id: GO:0017097
def: "Catalysis of the reaction: S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin. Melatonin is also known as N-acetyl-5-methoxytryptamine." [EC:2.1.1.4]
subset: gosubset_prok
synonym: "acetylserotonin methyltransferase activity" EXACT [EC:2.1.1.4]
synonym: "acetylserotonin N-methyltransferase activity" RELATED [KEGG:2.1.1.4]
synonym: "hydroxyindole methyltransferase activity" EXACT [EC:2.1.1.4]
synonym: "hydroxyindole O-methyltransferase activity" EXACT [EC:2.1.1.4]
synonym: "N-acetylserotonin O-methyltransferase activity" EXACT [EC:2.1.1.4]
synonym: "S-adenosyl-L-methionine:N-acetylserotonin O-methyltransferase activity" EXACT [EC:2.1.1.4]
xref: EC:2.1.1.4
xref: MetaCyc:ACETYLSEROTONIN-O-METHYLTRANSFERASE-RXN
xref: RHEA:15576
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0017098
name: sulfonylurea receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the sulfonylurea receptor, a regulatory subunit of the ATP-sensitive potassium ion channel." [GOC:ceb, PMID:11938023]
synonym: "sulfonylurea receptor ligand" NARROW []
synonym: "sulphonylurea receptor binding" EXACT []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0017099
name: very-long-chain-acyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a very long chain fatty acid residue. A very long-chain fatty acid is a fatty acid which has a chain length greater than C22." [CHEBI:27283, GOC:mah]
synonym: "very long-chain-acyl-CoA dehydrogenase activity" EXACT []
xref: EC:1.3.99.-
xref: Reactome:REACT_22330 "trans-octadec-2-enoyl-CoA + NADPH + H+ => stearoyl-CoA + NADP+, Homo sapiens"
is_a: GO:0004466 ! long-chain-acyl-CoA dehydrogenase activity

[Term]
id: GO:0017101
name: aminoacyl-tRNA synthetase multienzyme complex
namespace: cellular_component
def: "A multienzyme complex found in all multicellular eukaryotes composed of eight proteins with aminoacyl-tRNA synthetase activities (abbreviated as: ArgRS, AspRS, GluProRS, GlnRS, IleRS, LeuRS, LysRS, MetRS where RS is the enzyme, preceded by the amino acid it uses as a substrate) as well as three non-synthetase proteins (p43, p38, and p18) with diverse functions. Several of these subunits are known dimers, so the total polypeptide count in the multisynthetase complex is at least fifteen. All of the enzymes in this assembly catalyze the same reaction, the covalent attachment of an amino acid to either the 2'- or 3'-hydroxyl of the 3'-terminal adenosine of tRNA, but using different substrates." [GOC:jl, PMID:16169847]
synonym: "aminoacyl-tRNA synthetase complex" EXACT []
synonym: "multisynthetase complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0017102
name: methionyl glutamyl tRNA synthetase complex
namespace: cellular_component
def: "A complex consisting of methionyl- and glutamyl-tRNA synthetases. The tRNA synthetases present in the complex bind to their cognate tRNAs more efficiently than they do as monomers." [GOC:mcc, PMID:11069915]
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0017103
name: UTP:galactose-1-phosphate uridylyltransferase activity
namespace: molecular_function
alt_id: GO:0003982
def: "Catalysis of the reaction: alpha-D-galactose 1-phosphate + UTP = diphosphate + UDP-D-galactose." [EC:2.7.7.10, RHEA:14212]
synonym: "alpha-D-galactose 1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.10]
synonym: "Gal-1-P uridylyltransferase activity" BROAD [EC:2.7.7.10]
synonym: "galactose 1-phosphate uridyltransferase activity" EXACT [EC:2.7.7.10]
synonym: "galactose 1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.10]
synonym: "galactose-1-phosphate uridylyltransferase activity" BROAD [EC:2.7.7.10]
synonym: "UDPgalactose pyrophosphorylase activity" EXACT [EC:2.7.7.10]
synonym: "uridine diphosphate galactose pyrophosphorylase activity" EXACT [EC:2.7.7.10]
synonym: "uridine diphosphogalactose pyrophosphorylase activity" EXACT [EC:2.7.7.10]
synonym: "UTP-hexose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.10]
synonym: "UTP:alpha-D-hexose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.10]
synonym: "UTP:hexose-1-phosphate uridylyltransferase activity" BROAD []
xref: EC:2.7.7.10
xref: KEGG:R00502
xref: MetaCyc:UTPHEXPURIDYLYLTRANS-RXN
xref: RHEA:14212
is_a: GO:0051748 ! UTP-monosaccharide-1-phosphate uridylyltransferase activity

[Term]
id: GO:0017105
name: acyl-CoA delta11-desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + reduced acceptor + O2 = delta11-acyl-CoA + acceptor + 2 H2O." [EC:1.14.19.5]
synonym: "acyl-CoA D11-desaturase activity" EXACT []
synonym: "acyl-CoA delta(11)-desaturase activity" EXACT []
xref: EC:1.14.19.5
is_a: GO:0016215 ! acyl-CoA desaturase activity

[Term]
id: GO:0017106
name: obsolete activin inhibitor activity
namespace: molecular_function
def: "OBSOLETE. Acts to negatively regulate the activity of activin, a nonsteroidal regulator synthesized in the pituitary gland and gonads that stimulates the secretion of follicle-stimulating hormone." [ISBN:0198506732, ISBN:0721662544]
comment: This term was made obsolete because it refers to an obsolete molecular function term, 'activin'.
synonym: "activin inhibitor activity" EXACT []
is_obsolete: true
consider: GO:0004871

[Term]
id: GO:0017107
name: anion exchanger adaptor activity
namespace: molecular_function
def: "The binding activity of a molecule that brings together an anion exchanger and one or more other molecules, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07]
is_a: GO:0030674 ! protein binding, bridging

[Term]
id: GO:0017108
name: 5'-flap endonuclease activity
namespace: molecular_function
def: "Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis." [PMID:9778254]
synonym: "5' flap endonuclease activity" EXACT []
xref: Reactome:REACT_106924 "Removal of remaining Flap from the C-strand, Bos taurus"
xref: Reactome:REACT_110586 "Removal of remaining Flap from the C-strand, Xenopus tropicalis"
xref: Reactome:REACT_110813 "Removal of remaining Flap, Mus musculus"
xref: Reactome:REACT_2024 "Removal of remaining Flap, Homo sapiens"
xref: Reactome:REACT_2189 "Cleavage of flap structures, Homo sapiens"
xref: Reactome:REACT_28301 "Removal of remaining Flap from the C-strand, Danio rerio"
xref: Reactome:REACT_29570 "Cleavage of flap structures, Bos taurus"
xref: Reactome:REACT_29736 "Removal of remaining Flap from the C-strand, Oryza sativa"
xref: Reactome:REACT_32687 "Cleavage of flap structures, Danio rerio"
xref: Reactome:REACT_33124 "Removal of remaining Flap, Danio rerio"
xref: Reactome:REACT_79626 "Removal of remaining Flap, Oryza sativa"
xref: Reactome:REACT_7975 "Removal of remaining Flap from the C-strand, Homo sapiens"
xref: Reactome:REACT_80191 "Cleavage of flap structures, Arabidopsis thaliana"
xref: Reactome:REACT_80899 "Removal of remaining Flap, Xenopus tropicalis"
xref: Reactome:REACT_81149 "Cleavage of flap structures, Oryza sativa"
xref: Reactome:REACT_81201 "Removal of remaining Flap from the C-strand, Mus musculus"
xref: Reactome:REACT_82521 "Removal of remaining Flap, Schizosaccharomyces pombe"
xref: Reactome:REACT_88163 "Removal of remaining Flap, Bos taurus"
xref: Reactome:REACT_88514 "Cleavage of flap structures, Rattus norvegicus"
xref: Reactome:REACT_88760 "Removal of remaining Flap from the C-strand, Sus scrofa"
xref: Reactome:REACT_90619 "Cleavage of flap structures, Mus musculus"
xref: Reactome:REACT_92339 "Removal of remaining Flap from the C-strand, Rattus norvegicus"
xref: Reactome:REACT_94506 "Removal of remaining Flap, Sus scrofa"
xref: Reactome:REACT_96177 "Removal of remaining Flap, Arabidopsis thaliana"
xref: Reactome:REACT_96276 "Removal of remaining Flap from the C-strand, Schizosaccharomyces pombe"
xref: Reactome:REACT_97146 "Removal of remaining Flap from the C-strand, Arabidopsis thaliana"
xref: Reactome:REACT_97888 "Cleavage of flap structures, Xenopus tropicalis"
xref: Reactome:REACT_98183 "Removal of remaining Flap, Rattus norvegicus"
xref: Reactome:REACT_98512 "Cleavage of flap structures, Sus scrofa"
is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters
is_a: GO:0048256 ! flap endonuclease activity

[Term]
id: GO:0017109
name: glutamate-cysteine ligase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the ligation of glutamate to cysteine, forming glutamylcysteine." [EC:6.3.2.2]
synonym: "gamma-glutamylcysteine synthetase complex" EXACT []
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0017110
name: nucleoside-diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleotide + phosphate." [EC:3.6.1.6]
synonym: "apyrase activity" BROAD []
synonym: "IDPase" NARROW [EC:3.6.1.6]
synonym: "inosine 5'-diphosphatase" NARROW [EC:3.6.1.6]
synonym: "inosine diphosphatase" NARROW [EC:3.6.1.6]
synonym: "NDPase activity" EXACT [EC:3.6.1.6]
synonym: "nucleoside 5'-diphosphatase activity" EXACT [EC:3.6.1.6]
synonym: "nucleoside diphosphatase activity" EXACT []
synonym: "nucleoside diphosphate phosphatase activity" EXACT [EC:3.6.1.6]
synonym: "nucleoside diphosphate phosphohydrolase activity" EXACT [EC:3.6.1.6]
synonym: "nucleoside-diphosphate phosphohydrolase activity" EXACT [EC:3.6.1.6]
synonym: "type B nucleoside diphosphatase" NARROW [EC:3.6.1.6]
synonym: "type L nucleoside diphosphatase" NARROW [EC:3.6.1.6]
xref: EC:3.6.1.6
xref: MetaCyc:NUCLEOSIDE-DIPHOSPHATASE-RXN
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0017111
name: nucleoside-triphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]
subset: goslim_chembl
subset: gosubset_prok
synonym: "apyrase activity" BROAD []
synonym: "NTPase activity" EXACT [EC:3.6.1.15]
synonym: "nucleoside 5-triphosphatase activity" EXACT [EC:3.6.1.15]
synonym: "nucleoside triphosphatase activity" EXACT []
synonym: "nucleoside triphosphate hydrolase activity" EXACT [EC:3.6.1.15]
synonym: "nucleoside triphosphate phosphohydrolase activity" EXACT [EC:3.6.1.15]
synonym: "nucleoside-5-triphosphate phosphohydrolase activity" EXACT [EC:3.6.1.15]
synonym: "unspecific diphosphate phosphohydrolase activity" EXACT [EC:3.6.1.15]
xref: EC:3.6.1.15
xref: MetaCyc:NUCLEOSIDE-TRIPHOSPHATASE-RXN
xref: RHEA:23683
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0017112
name: Rab guanyl-nucleotide exchange factor activity
namespace: molecular_function
def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rab family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
is_a: GO:0005088 ! Ras guanyl-nucleotide exchange factor activity

[Term]
id: GO:0017113
name: dihydropyrimidine dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,6-dihydrouracil + NADP+ = uracil + NADPH + H+." [EC:1.3.1.2]
subset: gosubset_prok
synonym: "4,5-dihydrothymine: oxidoreductase activity" EXACT [EC:1.3.1.2]
synonym: "5,6-dihydrouracil:NADP+ 5-oxidoreductase activity" EXACT [EC:1.3.1.2]
synonym: "dehydrogenase, dihydrouracil (nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.3.1.2]
synonym: "DHPDH" RELATED [EC:1.3.1.2]
synonym: "DHU dehydrogenase activity" EXACT [EC:1.3.1.2]
synonym: "dihydropyrimidine dehydrogenase activity" EXACT []
synonym: "dihydrothymine dehydrogenase activity" RELATED [EC:1.3.1.2]
synonym: "dihydrouracil dehydrogenase (NADP)" EXACT [EC:1.3.1.2]
synonym: "dihydrouracil dehydrogenase (NADP+) activity" EXACT [EC:1.3.1.2]
synonym: "DPD" RELATED [EC:1.3.1.2]
synonym: "hydropyrimidine dehydrogenase activity" EXACT [EC:1.3.1.2]
xref: EC:1.3.1.2
xref: MetaCyc:1.3.1.2-RXN
xref: Reactome:REACT_100185 "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+, Bos taurus"
xref: Reactome:REACT_101500 "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+, Drosophila melanogaster"
xref: Reactome:REACT_102325 "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+, Escherichia coli"
xref: Reactome:REACT_102503 "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+, Caenorhabditis elegans"
xref: Reactome:REACT_102856 "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+, Oryza sativa"
xref: Reactome:REACT_104406 "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+, Xenopus tropicalis"
xref: Reactome:REACT_104716 "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+, Dictyostelium discoideum"
xref: Reactome:REACT_104929 "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+, Canis familiaris"
xref: Reactome:REACT_1067 "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+, Homo sapiens"
xref: Reactome:REACT_106968 "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+, Rattus norvegicus"
xref: Reactome:REACT_107377 "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+, Gallus gallus"
xref: Reactome:REACT_107631 "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+, Mus musculus"
xref: Reactome:REACT_28626 "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+, Danio rerio"
xref: Reactome:REACT_29373 "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+, Bos taurus"
xref: Reactome:REACT_31473 "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+, Danio rerio"
xref: Reactome:REACT_33387 "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+, Escherichia coli"
xref: Reactome:REACT_546 "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+, Homo sapiens"
xref: Reactome:REACT_78060 "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+, Xenopus tropicalis"
xref: Reactome:REACT_80344 "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+, Dictyostelium discoideum"
xref: Reactome:REACT_80891 "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+, Caenorhabditis elegans"
xref: Reactome:REACT_81619 "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+, Sus scrofa"
xref: Reactome:REACT_85525 "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+, Arabidopsis thaliana"
xref: Reactome:REACT_85843 "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+, Rattus norvegicus"
xref: Reactome:REACT_86765 "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+, Gallus gallus"
xref: Reactome:REACT_87828 "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+, Taeniopygia guttata"
xref: Reactome:REACT_88182 "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+, Mus musculus"
xref: Reactome:REACT_89315 "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+, Canis familiaris"
xref: Reactome:REACT_89636 "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+, Oryza sativa"
xref: Reactome:REACT_92348 "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+, Arabidopsis thaliana"
xref: Reactome:REACT_92956 "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+, Sus scrofa"
xref: Reactome:REACT_95786 "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+, Taeniopygia guttata"
xref: Reactome:REACT_98344 "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+, Drosophila melanogaster"
xref: RHEA:18096
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0017114
name: obsolete wide-spectrum protease inhibitor activity
namespace: molecular_function
def: "OBSOLETE. Stops, prevents or reduces the activity of a protease by a wide-spectrum protease inhibitor. A wide-spectrum protease inhibitor is a protein having a peptide stretch which contains specific cleavage sites for different proteinases enabling inhibition of all four classes of proteinases by formation of a covalent bond between the inhibitor and the protease." [GOC:dph, GOC:tb]
comment: This term was made obsolete because it represents a regulator of non-existent molecular function.
synonym: "wide-spectrum protease inhibitor activity" EXACT []
synonym: "wide-spectrum proteinase inhibitor" EXACT []
is_obsolete: true
replaced_by: GO:0030414

[Term]
id: GO:0017116
name: single-stranded DNA-dependent ATP-dependent DNA helicase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix." [EC:3.6.1.3, GOC:jl]
synonym: "ssDNA-dependent ATP-dependent DNA helicase activity" EXACT [GOC:mah]
is_a: GO:0004003 ! ATP-dependent DNA helicase activity
is_a: GO:0043142 ! single-stranded DNA-dependent ATPase activity

[Term]
id: GO:0017117
name: single-stranded DNA-dependent ATP-dependent DNA helicase complex
namespace: cellular_component
def: "A protein complex that possesses single-stranded DNA-dependent DNA helicase activity." [GOC:mah]
synonym: "ssDNA-dependent ATP-dependent DNA helicase complex" EXACT [GOC:mah]
is_a: GO:0033202 ! DNA helicase complex
is_a: GO:1904949 ! ATPase complex

[Term]
id: GO:0017118
name: lipoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of the lipoyl group from lipoyl-AMP to the lysine residue of lipoate-dependent enzyme." [PMID:10103005]
subset: gosubset_prok
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0017119
name: Golgi transport complex
namespace: cellular_component
def: "A complex of proteins that, in vitro, stimulates intra-Golgi transport; a 13S complex, about 800 kDa in size and consists of at least five polypeptides. In yeast, this complex is called the Sec34/35 complex and is composed of eight subunits (Sec34p, Sec35p, Dor1p, Cod1p, Cod2p, Cod3p, Cod4p, and Cod5p)." [GOC:krc, PMID:9792665]
synonym: "COG complex" EXACT []
synonym: "conserved oligomeric Golgi complex" EXACT []
synonym: "Sec34/35 complex" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044431 ! Golgi apparatus part

[Term]
id: GO:0017120
name: obsolete polyphosphatidylinositol phosphatase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the conversion of phosphatidylinositol-3-phosphate, phosphatidylinositol-4-phosphate, and phosphatidylinositol-3,5-bisphosphate, but not PI-4,5-bisphosphate, to phosphatidylinositol; PPIPase activity is a key regulator of membrane trafficking and actin cytoskeleton organization." [PMID:10224048]
comment: This term was made obsolete because it represents a gene product.
synonym: "polyphosphatidylinositol phosphatase activity" EXACT []
synonym: "polyphosphoinositide phosphatase activity" EXACT [GOC:curators]
is_obsolete: true
consider: GO:0004438
consider: GO:0034593
consider: GO:0043812

[Term]
id: GO:0017121
name: phospholipid scrambling
namespace: biological_process
def: "The movement of a population of phospholipid molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet, resulting in loss of lipid asymmetry and surface exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE)." [GOC:cjm, PMID:20043909, PMID:20302864]
comment: Note that this term describes the trans-bilayer motion of a population of phospholipid molecules, and should not be confused with 'phospholipid translocation ; GO:0045332'.
synonym: "PL scrambling" EXACT []
is_a: GO:0007009 ! plasma membrane organization
is_a: GO:0097035 ! regulation of membrane lipid distribution
relationship: has_part GO:0045332 ! phospholipid translocation

[Term]
id: GO:0017122
name: protein N-acetylglucosaminyltransferase complex
namespace: cellular_component
def: "Heterotrimeric enzyme complex, which in humans is composed of two large subunits of the same size, and one smaller subunit. Functions in the addition of nucleotide-activated sugars onto the polypeptide." [PMID:15247246]
synonym: "O-GlcNAc transferase complex" EXACT [GOC:mah]
synonym: "UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase" EXACT [GOC:mah]
is_a: GO:0044424 ! intracellular part
is_a: GO:1990234 ! transferase complex

[Term]
id: GO:0017124
name: SH3 domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins." [GOC:go_curators, Pfam:PF00018]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0017125
name: deoxycytidyl transferase activity
namespace: molecular_function
alt_id: GO:0019986
def: "Catalysis of the insertion of a dCMP residue opposite a template abasic site in DNA." [PMID:10535901]
synonym: "deoxycytidyl transferase activity, template-dependent" NARROW []
is_a: GO:0016779 ! nucleotidyltransferase activity

[Term]
id: GO:0017126
name: nucleologenesis
namespace: biological_process
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells." [GOC:jl, ISBN:0198506732]
synonym: "nucleolus assembly" NARROW [GOC:mah]
synonym: "nucleolus biogenesis" EXACT []
is_a: GO:0007000 ! nucleolus organization
is_a: GO:0044085 ! cellular component biogenesis

[Term]
id: GO:0017127
name: cholesterol transporter activity
namespace: molecular_function
def: "Enables the directed movement of cholesterol into, out of or within a cell, or between cells. Cholesterol is the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:ai]
xref: Reactome:REACT_102091 "ABCA1-mediated transport of intracellular cholesterol to the cell surface, Danio rerio"
xref: Reactome:REACT_102928 "ABCG1-mediated transport of intracellular cholesterol to the cell surface, Rattus norvegicus"
xref: Reactome:REACT_103584 "NPC1L1-mediated phytosterol uptake, Arabidopsis thaliana"
xref: Reactome:REACT_103752 "ABCA1-mediated transport of intracellular cholesterol to the cell surface, Sus scrofa"
xref: Reactome:REACT_103843 "ABCA1-mediated transport of intracellular cholesterol to the cell surface, Mus musculus"
xref: Reactome:REACT_105141 "NPC1L1-mediated cholesterol uptake, Mus musculus"
xref: Reactome:REACT_105208 "NPC1L1-mediated cholesterol uptake, Saccharomyces cerevisiae"
xref: Reactome:REACT_105941 "NPC1L1-mediated phytosterol uptake, Canis familiaris"
xref: Reactome:REACT_105987 "NPC1L1-mediated phytosterol uptake, Xenopus tropicalis"
xref: Reactome:REACT_107839 "NPC1L1-mediated cholesterol uptake, Danio rerio"
xref: Reactome:REACT_110989 "NPC1L1-mediated phytosterol uptake, Sus scrofa"
xref: Reactome:REACT_111034 "ABCG4 may mediate cholesterol efflux, Homo sapiens"
xref: Reactome:REACT_112797 "NPC1L1-mediated cholesterol uptake, Plasmodium falciparum"
xref: Reactome:REACT_112970 "NPC1L1-mediated phytosterol uptake, Plasmodium falciparum"
xref: Reactome:REACT_113155 "ABCG1-mediated transport of intracellular cholesterol to the cell surface, Taeniopygia guttata"
xref: Reactome:REACT_113203 "ABCG1-mediated transport of intracellular cholesterol to the cell surface, Xenopus tropicalis"
xref: Reactome:REACT_13411 "NPC1L1-mediated cholesterol uptake, Homo sapiens"
xref: Reactome:REACT_13559 "NPC1L1-mediated phytosterol uptake, Homo sapiens"
xref: Reactome:REACT_13622 "ABCA1-mediated transport of intracellular cholesterol to the cell surface, Homo sapiens"
xref: Reactome:REACT_13681 "ABCG1-mediated transport of intracellular cholesterol to the cell surface, Homo sapiens"
xref: Reactome:REACT_13730 "NPC1L1-mediated cholesterol uptake, Canis familiaris"
xref: Reactome:REACT_29243 "NPC1L1-mediated cholesterol uptake, Dictyostelium discoideum"
xref: Reactome:REACT_30910 "ABCG1-mediated transport of intracellular cholesterol to the cell surface, Canis familiaris"
xref: Reactome:REACT_31143 "NPC1L1-mediated cholesterol uptake, Sus scrofa"
xref: Reactome:REACT_34526 "NPC1L1-mediated phytosterol uptake, Danio rerio"
xref: Reactome:REACT_77108 "ABCA1-mediated transport of intracellular cholesterol to the cell surface, Canis familiaris"
xref: Reactome:REACT_78437 "ABCG1-mediated transport of intracellular cholesterol to the cell surface, Drosophila melanogaster"
xref: Reactome:REACT_78487 "NPC1L1-mediated phytosterol uptake, Oryza sativa"
xref: Reactome:REACT_78628 "ABCA1-mediated transport of intracellular cholesterol to the cell surface, Xenopus tropicalis"
xref: Reactome:REACT_79370 "ABCA1-mediated transport of intracellular cholesterol to the cell surface, Gallus gallus"
xref: Reactome:REACT_80282 "NPC1L1-mediated cholesterol uptake, Xenopus tropicalis"
xref: Reactome:REACT_80650 "NPC1L1-mediated phytosterol uptake, Dictyostelium discoideum"
xref: Reactome:REACT_82880 "ABCA1-mediated transport of intracellular cholesterol to the cell surface, Bos taurus"
xref: Reactome:REACT_83717 "ABCG1-mediated transport of intracellular cholesterol to the cell surface, Bos taurus"
xref: Reactome:REACT_83811 "ABCG1-mediated transport of intracellular cholesterol to the cell surface, Mus musculus"
xref: Reactome:REACT_84159 "NPC1L1-mediated cholesterol uptake, Caenorhabditis elegans"
xref: Reactome:REACT_85082 "NPC1L1-mediated phytosterol uptake, Bos taurus"
xref: Reactome:REACT_86312 "ABCG1-mediated transport of intracellular cholesterol to the cell surface, Gallus gallus"
xref: Reactome:REACT_86389 "ABCG1-mediated transport of intracellular cholesterol to the cell surface, Danio rerio"
xref: Reactome:REACT_88429 "NPC1L1-mediated cholesterol uptake, Arabidopsis thaliana"
xref: Reactome:REACT_90738 "NPC1L1-mediated cholesterol uptake, Oryza sativa"
xref: Reactome:REACT_97357 "NPC1L1-mediated phytosterol uptake, Caenorhabditis elegans"
xref: Reactome:REACT_97583 "NPC1L1-mediated phytosterol uptake, Saccharomyces cerevisiae"
xref: Reactome:REACT_97716 "NPC1L1-mediated phytosterol uptake, Mus musculus"
xref: Reactome:REACT_99428 "NPC1L1-mediated cholesterol uptake, Bos taurus"
is_a: GO:0015248 ! sterol transporter activity
relationship: part_of GO:0030301 ! cholesterol transport

[Term]
id: GO:0017128
name: phospholipid scramblase activity
namespace: molecular_function
def: "Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, by an ATP-independent mechanism." [GOC:cjm, PMID:20043909, PMID:20302864]
is_a: GO:0005548 ! phospholipid transporter activity
relationship: part_of GO:0017121 ! phospholipid scrambling

[Term]
id: GO:0017129
name: triglyceride binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any triester of glycerol." [GOC:jl, ISBN:0198506732]
synonym: "triacylglycerol binding" EXACT [GOC:mah]
is_a: GO:0008289 ! lipid binding

[Term]
id: GO:0017130
name: poly(C) RNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of cytosine residues in an RNA molecule." [GOC:mah]
synonym: "poly(C) binding" BROAD [GOC:mah]
synonym: "poly(rC) binding" EXACT [GOC:mah]
is_a: GO:0008187 ! poly-pyrimidine tract binding

[Term]
id: GO:0017131
name: uridine-rich cytoplasmic polyadenylylation element binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with U-rich sequence in the 3'-end of nuclear-transcribed mRNAs; required for cytoplasmic polyadenylylation." [GOC:krc, PMID:7954828]
synonym: "U-rich CPE binding" EXACT [PMID:7954828]
synonym: "uridine-rich cytoplasmic polyadenylation element binding" EXACT []
is_a: GO:0008187 ! poly-pyrimidine tract binding

[Term]
id: GO:0017132
name: cyclic nucleotide-dependent guanyl-nucleotide exchange factor activity
namespace: molecular_function
def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase; dependent on the presence of a cyclic nucleotide." [GOC:mah, PMID:9856955]
is_a: GO:0005085 ! guanyl-nucleotide exchange factor activity

[Term]
id: GO:0017133
name: mitochondrial electron transfer flavoprotein complex
namespace: cellular_component
def: "A protein complex located in the mitochondrion. It contains flavin adenine dinucleotide (FAD) that, together with an acyl-CoA dehydrogenase, forms a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors in the mitochondrial electron transport system." [GOC:mtg_sensu, ISBN:0198506732]
is_a: GO:0045251 ! electron transfer flavoprotein complex
is_a: GO:0098798 ! mitochondrial protein complex
intersection_of: GO:0045251 ! electron transfer flavoprotein complex
intersection_of: part_of GO:0005739 ! mitochondrion
relationship: part_of GO:0005739 ! mitochondrion
relationship: part_of GO:0005759 ! mitochondrial matrix

[Term]
id: GO:0017134
name: fibroblast growth factor binding
namespace: molecular_function
alt_id: GO:0048602
alt_id: GO:0048603
alt_id: GO:0048604
alt_id: GO:0048605
alt_id: GO:0048606
alt_id: GO:0048607
def: "Interacting selectively and non-covalently with a fibroblast growth factor." [PMID:9806903]
synonym: "FGF 1 binding" NARROW []
synonym: "FGF 2 binding" NARROW []
synonym: "FGF 3 binding" NARROW []
synonym: "FGF 4 binding" NARROW []
synonym: "FGF 5 binding" NARROW []
synonym: "FGF 6 binding" NARROW []
synonym: "FGF binding" EXACT []
synonym: "fibroblast growth factor 1 binding" NARROW []
synonym: "fibroblast growth factor 2 binding" NARROW []
synonym: "fibroblast growth factor 3 binding" NARROW []
synonym: "fibroblast growth factor 4 binding" NARROW []
synonym: "fibroblast growth factor 5 binding" NARROW []
synonym: "fibroblast growth factor 6 binding" NARROW []
is_a: GO:0019838 ! growth factor binding

[Term]
id: GO:0017135
name: obsolete membrane-associated protein with guanylate kinase activity interacting
namespace: molecular_function
def: "OBSOLETE. The interaction with synapse-associated membrane-associated protein with guanylate kinase activity." [PMID:10207005]
comment: This term was made obsolete because it does not represent a molecular function and the term name appears to make no sense.
synonym: "membrane-associated protein with guanylate kinase activity interacting" EXACT []
is_obsolete: true
consider: GO:0019899

[Term]
id: GO:0017136
name: NAD-dependent histone deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from a histone." [EC:3.5.1.17, RHEA:24551]
synonym: "SIR2" RELATED []
is_a: GO:0004407 ! histone deacetylase activity
is_a: GO:0034979 ! NAD-dependent protein deacetylase activity

[Term]
id: GO:0017137
name: Rab GTPase binding
namespace: molecular_function
alt_id: GO:0005084
def: "Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases." [GOC:mah]
synonym: "Rab escort protein activity" NARROW []
synonym: "Rab interactor activity" RELATED []
synonym: "REP" NARROW []
is_a: GO:0017016 ! Ras GTPase binding

[Term]
id: GO:0017139
name: obsolete arsenate sensitivity/resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process.
synonym: "arsenate sensitivity/resistance" EXACT []
is_obsolete: true
replaced_by: GO:0046685

[Term]
id: GO:0017141
name: obsolete antibiotic susceptibility/resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process.
synonym: "antibiotic susceptibility/resistance" EXACT []
is_obsolete: true
replaced_by: GO:0046677

[Term]
id: GO:0017142
name: obsolete toxin susceptibility/resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process.
synonym: "toxin susceptibility/resistance" EXACT []
is_obsolete: true
replaced_by: GO:0009636

[Term]
id: GO:0017143
name: insecticide metabolic process
namespace: biological_process
alt_id: GO:0017138
def: "The chemical reactions and pathways involving insecticides, chemicals used to kill insects." [GOC:ai]
subset: gosubset_prok
synonym: "insecticide metabolism" EXACT []
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0009404 ! toxin metabolic process
relationship: part_of GO:0017085 ! response to insecticide

[Term]
id: GO:0017144
name: drug metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a drug, a substance used in the diagnosis, treatment or prevention of a disease; as used here antibiotic substances (see antibiotic metabolism) are considered to be drugs, even if not used in medical or veterinary practice." [GOC:cab2]
subset: goslim_chembl
subset: goslim_pir
subset: gosubset_prok
synonym: "drug metabolism" EXACT []
xref: Reactome:REACT_100188 "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI), Danio rerio"
xref: Reactome:REACT_106588 "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI), Canis familiaris"
xref: Reactome:REACT_109592 "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI), Taeniopygia guttata"
xref: Reactome:REACT_110347 "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI), Gallus gallus"
xref: Reactome:REACT_163 "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI), Homo sapiens"
xref: Reactome:REACT_54870 "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI), Bos taurus"
xref: Reactome:REACT_85142 "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI), Mus musculus"
xref: Reactome:REACT_88376 "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI), Rattus norvegicus"
xref: Reactome:REACT_92052 "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI), Sus scrofa"
xref: Wikipedia:Drug_metabolism
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0017145
name: stem cell division
namespace: biological_process
def: "The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types." [GOC:jid, ISBN:0582227089]
synonym: "stem cell renewal" EXACT []
is_a: GO:0051301 ! cell division

[Term]
id: GO:0017146
name: NMDA selective glutamate receptor complex
namespace: cellular_component
def: "An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. NMDA receptors are composed of assemblies of NR1 subunits (Figure 3) and NR2 subunits, which can be one of four separate gene products (NR2A-D). Expression of both subunits are required to form functional channels. The glutamate binding domain is formed at the junction of NR1 and NR2 subunits. NMDA receptors are permeable to calcium ions as well as being permeable to other ions. Thus NMDA receptor activation leads to a calcium influx into the post-synaptic cells, a signal thought to be crucial for the induction of NMDA-receptor dependent LTP and LTD." [http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html]
synonym: "N-methyl-D-aspartate selective glutamate receptor complex" EXACT []
synonym: "NMDA-selective glutamate receptor" EXACT []
is_a: GO:0008328 ! ionotropic glutamate receptor complex

[Term]
id: GO:0017147
name: Wnt-protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling." [GOC:jl]
subset: goslim_chembl
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0017148
name: negative regulation of translation
namespace: biological_process
alt_id: GO:0016478
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:isa_complete]
subset: gosubset_prok
synonym: "down regulation of protein biosynthetic process" EXACT []
synonym: "down-regulation of protein biosynthetic process" EXACT []
synonym: "downregulation of protein biosynthetic process" EXACT []
synonym: "inhibition of protein biosynthetic process" NARROW []
synonym: "negative regulation of protein anabolism" EXACT []
synonym: "negative regulation of protein biosynthesis" EXACT []
synonym: "negative regulation of protein biosynthetic process" EXACT []
synonym: "negative regulation of protein formation" EXACT []
synonym: "negative regulation of protein synthesis" EXACT []
synonym: "protein biosynthesis inhibitor activity" RELATED []
synonym: "protein biosynthetic process inhibitor activity" RELATED []
is_a: GO:0006417 ! regulation of translation
is_a: GO:0010629 ! negative regulation of gene expression
is_a: GO:0032269 ! negative regulation of cellular protein metabolic process
is_a: GO:0034249 ! negative regulation of cellular amide metabolic process
is_a: GO:2000113 ! negative regulation of cellular macromolecule biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006412 ! translation
relationship: negatively_regulates GO:0006412 ! translation

[Term]
id: GO:0017149
name: obsolete protein biosynthetic process inhibitor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents involvement in a biological process.
synonym: "protein anabolism inhibitor activity" EXACT []
synonym: "protein biosynthetic process inhibitor activity" EXACT []
synonym: "protein formation inhibitor activity" EXACT []
synonym: "protein synthesis inhibitor activity" EXACT []
is_obsolete: true
replaced_by: GO:0017148

[Term]
id: GO:0017150
name: tRNA dihydrouridine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: tRNA-uracil + acceptor = tRNA-dihydrouridine + reduced acceptor." [PMID:11983710]
subset: gosubset_prok
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors
relationship: part_of GO:0002943 ! tRNA dihydrouridine synthesis

[Term]
id: GO:0017151
name: DEAD/H-box RNA helicase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the enzyme DEAD/H-box RNA helicase." [GOC:jl]
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0017153
name: sodium:dicarboxylate symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in)." [GOC:ai]
subset: gosubset_prok
synonym: "sodium:dicarboxylate cotransporter activity" BROAD []
is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity
is_a: GO:0005343 ! organic acid:sodium symporter activity
is_a: GO:0015296 ! anion:cation symporter activity

[Term]
id: GO:0017154
name: semaphorin receptor activity
namespace: molecular_function
def: "Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling, PMID:15239958]
is_a: GO:0004888 ! transmembrane signaling receptor activity
relationship: part_of GO:0071526 ! semaphorin-plexin signaling pathway

[Term]
id: GO:0017155
name: obsolete sodium:hydrogen antiporter regulator activity
namespace: molecular_function
alt_id: GO:0030040
def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729]
comment: This term was made obsolete because it represents a biological process.
synonym: "sodium:hydrogen antiporter regulator activity" EXACT []
synonym: "sodium:proton antiporter regulator" EXACT []
is_obsolete: true

[Term]
id: GO:0017156
name: calcium ion regulated exocytosis
namespace: biological_process
def: "The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels." [GOC:go_curators]
comment: Note that the calcium regulated exocytosis pathway can be leaky: some level of exocytosis via this pathway occurs spontaneously.  This phenomenon underlies spontaneous neurotransmitter release from presynapses.  This phenomenon is distinct from the unregulated, calcium independent exocytosis pathway.
synonym: "calcium ion-dependent exocytosis" EXACT []
is_a: GO:0045055 ! regulated exocytosis

[Term]
id: GO:0017157
name: regulation of exocytosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of exocytosis." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0060627 ! regulation of vesicle-mediated transport
is_a: GO:1903530 ! regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006887 ! exocytosis
relationship: regulates GO:0006887 ! exocytosis

[Term]
id: GO:0017158
name: regulation of calcium ion-dependent exocytosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis." [GOC:go_curators]
is_a: GO:1903305 ! regulation of regulated secretory pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0017156 ! calcium ion regulated exocytosis
relationship: regulates GO:0017156 ! calcium ion regulated exocytosis

[Term]
id: GO:0017159
name: pantetheine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-pantetheine + H(2)O = (R)-pantothenate + cysteamine." [EC:3.5.1.92, RHEA:13448]
synonym: "(R)-pantetheine amidohydrolase activity" EXACT [EC:3.5.1.92]
synonym: "pantetheinase activity" EXACT [EC:3.5.1.92]
synonym: "vanin" RELATED [EC:3.5.1.92]
synonym: "vanin-1" RELATED [EC:3.5.1.92]
xref: EC:3.5.1.92
xref: KEGG:R02973
xref: MetaCyc:3.5.1.92-RXN
xref: RHEA:13448
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0017160
name: Ral GTPase binding
namespace: molecular_function
alt_id: GO:0034989
def: "Interacting selectively and non-covalently with Ral protein, any member of the Ral subfamily of the Ras superfamily of monomeric GTPases." [GOC:mah]
synonym: "GTP-Ral binding" NARROW []
synonym: "Ral interactor activity" RELATED []
is_a: GO:0017016 ! Ras GTPase binding

[Term]
id: GO:0017161
name: inositol-1,3,4-trisphosphate 4-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-myo-inositol 1,3,4-trisphosphate + H2O = myo-inositol 1,3-bisphosphate + phosphate." [GOC:ai]
xref: EC:3.1.3.-
is_a: GO:0046030 ! inositol trisphosphate phosphatase activity

[Term]
id: GO:0017162
name: aryl hydrocarbon receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an aryl hydrocarbon receptor." [GOC:ai]
is_a: GO:0005102 ! receptor binding
is_a: GO:0008134 ! transcription factor binding

[Term]
id: GO:0017163
name: obsolete basal transcription repressor activity
namespace: molecular_function
def: "OBSOLETE. Any transcription regulator activity that prevents or downregulates basal transcription. Basal transcription results from transcription that is controlled by the minimal complement of proteins necessary to reconstitute transcription from a minimal promoter." [GOC:dph, GOC:tb, http://tfib.med.harvard.edu/transcription/basaltx.html]
comment: This term was obsoleted because "general/nonspecific/basal" transcription vs "specific" transcription were determined not to be separable, distinct process. Thus, terms trying to distinguish "general/nonspecific/basal" transcription from "specific" transcription were removed from both the Molecular Function and the Biological Process ontologies. In addition, this Molecular Function term was defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of your repressor is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
subset: gosubset_prok
synonym: "basal transcription repressor activity" EXACT []
is_obsolete: true
consider: GO:0001078
consider: GO:0001141
consider: GO:0045892

[Term]
id: GO:0017164
name: obsolete nicotinic acetylcholine receptor-associated protein activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product and not a molecular function.
synonym: "nicotinic acetylcholine receptor-associated protein activity" EXACT []
is_obsolete: true
consider: GO:0005102
consider: GO:0005515

[Term]
id: GO:0017165
name: obsolete dipeptidase E activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of dipeptides Asp-Xaa; does not act on peptides with N-terminal Glu, Asn or Gln, nor does it cleave isoaspartyl peptides." [EC:3.4.13.21]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "alpha-aspartyl dipeptidase activity" EXACT []
synonym: "aspartyl dipeptidase activity" EXACT [EC:3.4.13.21]
synonym: "dipeptidase E activity" EXACT []
synonym: "PepE gene product (Salmonella typhimurium) activity" NARROW [EC:3.4.13.21]
synonym: "peptidase E activity" BROAD [EC:3.4.13.21]
xref: EC:3.4.13.21
xref: MetaCyc:3.4.13.21-RXN
is_obsolete: true
replaced_by: GO:0016805

[Term]
id: GO:0017166
name: vinculin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with vinculin, a protein found in muscle, fibroblasts, and epithelial cells that binds actin and appears to mediate attachment of actin filaments to integral proteins of the plasma membrane." [ISBN:0721662544]
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0017168
name: 5-oxoprolinase (ATP-hydrolyzing) activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-oxo-L-proline + ATP + 2 H(2)O = L-glutamate + ADP + 2 H(+) + phosphate." [EC:3.5.2.9, RHEA:10351]
subset: gosubset_prok
synonym: "5-OPase activity" EXACT [EC:3.5.2.9]
synonym: "5-oxo-L-prolinase activity" EXACT [EC:3.5.2.9]
synonym: "5-oxo-L-proline amidohydrolase (ATP-hydrolysing)" EXACT [EC:3.5.2.9]
synonym: "5-oxoprolinase (ATP-hydrolysing)" EXACT [EC:3.5.2.9]
synonym: "5-oxoprolinase activity" EXACT [EC:3.5.2.9]
synonym: "L-pyroglutamate hydrolase activity" EXACT [EC:3.5.2.9]
synonym: "oxoprolinase activity" EXACT [EC:3.5.2.9]
synonym: "pyroglutamase (ATP-hydrolysing)" EXACT [EC:3.5.2.9]
synonym: "pyroglutamase (ATP-hydrolyzing) activity" EXACT [EC:3.5.2.9]
synonym: "pyroglutamase activity" EXACT [EC:3.5.2.9]
synonym: "pyroglutamate hydrolase activity" EXACT [EC:3.5.2.9]
synonym: "pyroglutamic hydrolase activity" EXACT [EC:3.5.2.9]
xref: EC:3.5.2.9
xref: KEGG:R00251
xref: MetaCyc:5-OXOPROLINASE-ATP-HYDROLYSING-RXN
xref: Reactome:REACT_75909 "Cleavage of 5-oxoproline to form glutamate, Homo sapiens"
xref: RHEA:10351
xref: Wikipedia:5-oxoprolinase_(ATP-hydrolysing)
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0017169
name: CDP-alcohol phosphatidyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CDP + alcohol = CMP + phosphatidyl alcohol." [GOC:ai]
subset: gosubset_prok
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0017170
name: obsolete KU70 binding
namespace: molecular_function
def: "OBSOLETE. Interacting selectively and non-covalently with Ku70, a protein involved in non-homologous DNA end joining." [GOC:mah, PMID:14739985]
comment: This term was made obsolete because it represents binding to an individual protein.
synonym: "KU70 binding" EXACT []
is_obsolete: true

[Term]
id: GO:0017171
name: serine hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [Wikipedia:Serine_hydrolase]
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0017172
name: cysteine dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-cysteine + O(2) = 3-sulfino-L-alanine + H(+)." [EC:1.13.11.20, RHEA:20444]
subset: gosubset_prok
xref: EC:1.13.11.20
xref: KEGG:R00893
xref: MetaCyc:CYSTEINE-DIOXYGENASE-RXN
xref: Reactome:REACT_115785 "Cysteine is oxidized, Homo sapiens"
xref: RHEA:20444
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0017174
name: glycine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine." [EC:2.1.1.20]
synonym: "glycine methyltransferase activity" EXACT [EC:2.1.1.20]
synonym: "GNMT" RELATED [EC:2.1.1.20]
synonym: "S-adenosyl-L-methionine:glycine methyltransferase activity" EXACT [EC:2.1.1.20]
synonym: "S-adenosyl-L-methionine:glycine N-methyltransferase activity" EXACT [EC:2.1.1.20]
xref: EC:2.1.1.156
xref: EC:2.1.1.162
xref: EC:2.1.1.20
xref: KEGG:R00367
xref: MetaCyc:2.1.1.162-RXN
xref: MetaCyc:GLYCINE-N-METHYLTRANSFERASE-RXN
xref: RHEA:19940
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0017175
name: obsolete IMP-GMP specific 5'-nucleotidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the conversion of 5'-ribonucleotides to ribonucleosides and phosphate, with specificity for IMP or GMP 5'-ribonucleotides and H2O as a nucleophile." [EC:3.1.3.5, GOC:krc]
comment: This term was made obsolete because it represents a gene product with two different activities.
synonym: "IMP-GMP specific 5'-nucleotidase activity" EXACT []
is_obsolete: true
consider: GO:0050484

[Term]
id: GO:0017176
name: phosphatidylinositol N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + phosphatidylinositol = UDP + N-acetyl-D-glucosaminylphosphatidylinositol." [EC:2.4.1.198]
synonym: "UDP-N-acetyl-D-glucosamine:1-phosphatidyl-1D-myo-inositol 6-(N-acetyl-alpha-D-glucosaminyl)transferase activity" EXACT [EC:2.4.1.198]
synonym: "UDP-N-acetyl-D-glucosamine:phosphatidylinositol N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.198]
synonym: "uridine diphosphoacetylglucosamine alpha-1,6-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.198]
synonym: "uridine diphosphoacetylglucosamine alpha1,6-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.198]
xref: EC:2.4.1.198
xref: MetaCyc:2.4.1.198-RXN
xref: RHEA:14792
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0017177
name: glucosidase II complex
namespace: cellular_component
def: "A heterodimeric complex that catalyzes the trimming of glucose residues from N-linked core glycans on newly synthesized glycoproteins." [PMID:10464333, PMID:8910335]
comment: Note that alpha-glucosidase I functions as a monomer, and therefore does not have a corresponding cellular component term.
synonym: "alpha-glucosidase II complex" RELATED [GOC:19605557, GOC:vw]
is_a: GO:0043234 ! protein complex
is_a: GO:0044432 ! endoplasmic reticulum part

[Term]
id: GO:0017178
name: diphthine-ammonia ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + diphthine + NH(4)(+) = ADP + diphthamide + H(+) + phosphate." [EC:6.3.1.14, RHEA:19756]
synonym: "diphthamide synthase activity" EXACT [EC:6.3.1.14]
synonym: "diphthamide synthetase activity" EXACT [EC:6.3.1.14]
synonym: "diphthine:ammonia ligase (ADP-forming)" EXACT [EC:6.3.1.14]
xref: EC:6.3.1.14
xref: KEGG:R03613
xref: MetaCyc:DIPHTINE--AMMONIA-LIGASE-RXN
xref: RHEA:19756
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0017179
name: peptidyl-diphthine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving peptidyl-diphthine, a modified histidine residue." [GOC:go_curators]
subset: gosubset_prok
synonym: "peptidyl-diphthine metabolism" EXACT []
is_a: GO:0018202 ! peptidyl-histidine modification

[Term]
id: GO:0017180
name: peptidyl-diphthine biosynthetic process from peptidyl-histidine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of peptidyl-diphthine from other compounds, including peptidyl-histidine." [GOC:go_curators]
subset: gosubset_prok
synonym: "peptidyl-diphthine anabolism from peptidyl-histidine" EXACT []
synonym: "peptidyl-diphthine formation from peptidyl-histidine" EXACT []
synonym: "peptidyl-diphthine synthesis from peptidyl-histidine" EXACT []
is_a: GO:0017179 ! peptidyl-diphthine metabolic process
is_a: GO:0044249 ! cellular biosynthetic process
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0017181
name: peptidyl-diphthine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of peptidyl-diphthine, a modified histidine residue." [GOC:go_curators]
subset: gosubset_prok
synonym: "peptidyl-diphthine breakdown" EXACT []
synonym: "peptidyl-diphthine catabolism" EXACT []
synonym: "peptidyl-diphthine degradation" EXACT []
is_a: GO:0017179 ! peptidyl-diphthine metabolic process
is_a: GO:0042219 ! cellular modified amino acid catabolic process
is_a: GO:0044248 ! cellular catabolic process

[Term]
id: GO:0017182
name: peptidyl-diphthamide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving peptidyl-diphthamide, a modified histidine residue." [GOC:go_curators]
subset: gosubset_prok
synonym: "peptidyl-diphthamide metabolism" EXACT []
is_a: GO:0018202 ! peptidyl-histidine modification

[Term]
id: GO:0017183
name: peptidyl-diphthamide biosynthetic process from peptidyl-histidine
namespace: biological_process
def: "The modification of peptidyl-histidine to 2'-(3-carboxamido-3-(trimethylammonio)propyl)-L-histidine, known as diphthamide, found in translation elongation factor EF-2. The process occurs in eukaryotes and archaea but not eubacteria." [GOC:pde, PMID:20559380, RESID:AA0040]
subset: gosubset_prok
synonym: "peptidyl-diphthamide anabolism from peptidyl-histidine" EXACT []
synonym: "peptidyl-diphthamide formation from peptidyl-histidine" EXACT []
synonym: "peptidyl-diphthamide synthesis from peptidyl-histidine" EXACT []
xref: RESID:AA0040
is_a: GO:0017182 ! peptidyl-diphthamide metabolic process
is_a: GO:0044249 ! cellular biosynthetic process
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0017184
name: peptidyl-diphthamide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of peptidyl-diphthamide, a modified histidine residue." [GOC:go_curators]
subset: gosubset_prok
synonym: "peptidyl-diphthamide breakdown" EXACT []
synonym: "peptidyl-diphthamide catabolism" EXACT []
synonym: "peptidyl-diphthamide degradation" EXACT []
is_a: GO:0017182 ! peptidyl-diphthamide metabolic process
is_a: GO:0042219 ! cellular modified amino acid catabolic process
is_a: GO:0044248 ! cellular catabolic process

[Term]
id: GO:0017185
name: peptidyl-lysine hydroxylation
namespace: biological_process
def: "The hydroxylation of peptidyl-lysine to form peptidyl-hydroxylysine." [GOC:ai]
subset: gosubset_prok
is_a: GO:0018126 ! protein hydroxylation
is_a: GO:0018205 ! peptidyl-lysine modification

[Term]
id: GO:0017186
name: peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of peptidyl-pyroglutamic acid, catalyzed by glutaminyl-peptide cyclotransferase." [RESID:AA0031]
comment: See also the molecular function term 'glutaminyl-peptide cyclotransferase activity ; GO:0016603'.
subset: gosubset_prok
synonym: "2-pyrrolidone-5-carboxylic acid biosynthesis" EXACT []
synonym: "2-pyrrolidone-5-carboxylic acid biosynthetic process" EXACT []
synonym: "peptidyl-pyroglutamic acid anabolism, using glutaminyl-peptide cyclotransferase" EXACT []
synonym: "peptidyl-pyroglutamic acid formation, using glutaminyl-peptide cyclotransferase" EXACT []
synonym: "peptidyl-pyroglutamic acid synthesis, using glutaminyl-peptide cyclotransferase" EXACT []
xref: RESID:AA0031
is_a: GO:0018199 ! peptidyl-glutamine modification

[Term]
id: GO:0017187
name: peptidyl-glutamic acid carboxylation
namespace: biological_process
def: "The gamma-carboxylation of peptidyl-glutamic acid; catalyzed by the vitamin K dependent gamma-glutamyl carboxylase." [RESID:AA0032]
comment: See also the molecular function term 'gamma-glutamyl carboxylase activity ; GO:0008488'.
subset: gosubset_prok
xref: Reactome:REACT_101724 "Gamma-carboxylation, transport, and amino-terminal cleavage of proteins, Gallus gallus"
xref: Reactome:REACT_103998 "Gamma-carboxylation of protein precursors, Mus musculus"
xref: Reactome:REACT_1050 "Gamma-carboxylation of protein precursors, Homo sapiens"
xref: Reactome:REACT_108829 "Gamma-carboxylation, transport, and amino-terminal cleavage of proteins, Mus musculus"
xref: Reactome:REACT_109716 "Gamma-carboxylation, transport, and amino-terminal cleavage of proteins, Canis familiaris"
xref: Reactome:REACT_110221 "Gamma-carboxylation of protein precursors, Xenopus tropicalis"
xref: Reactome:REACT_1132 "Gamma-carboxylation, transport, and amino-terminal cleavage of proteins, Homo sapiens"
xref: Reactome:REACT_113315 "Gamma-carboxylation, transport, and amino-terminal cleavage of proteins, Drosophila melanogaster"
xref: Reactome:REACT_30172 "Gamma-carboxylation of protein precursors, Bos taurus"
xref: Reactome:REACT_31819 "Gamma-carboxylation of protein precursors, Canis familiaris"
xref: Reactome:REACT_31904 "Gamma-carboxylation, transport, and amino-terminal cleavage of proteins, Danio rerio"
xref: Reactome:REACT_84294 "Gamma-carboxylation, transport, and amino-terminal cleavage of proteins, Xenopus tropicalis"
xref: Reactome:REACT_87040 "Gamma-carboxylation, transport, and amino-terminal cleavage of proteins, Sus scrofa"
xref: Reactome:REACT_88536 "Gamma-carboxylation of protein precursors, Rattus norvegicus"
xref: Reactome:REACT_92653 "Gamma-carboxylation, transport, and amino-terminal cleavage of proteins, Bos taurus"
xref: Reactome:REACT_93656 "Gamma-carboxylation, transport, and amino-terminal cleavage of proteins, Rattus norvegicus"
xref: Reactome:REACT_99451 "Gamma-carboxylation of protein precursors, Danio rerio"
xref: Reactome:REACT_99589 "Gamma-carboxylation, transport, and amino-terminal cleavage of proteins, Taeniopygia guttata"
xref: RESID:AA0032
is_a: GO:0018200 ! peptidyl-glutamic acid modification
is_a: GO:0018214 ! protein carboxylation

[Term]
id: GO:0017188
name: aspartate N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-aspartate + acetyl-CoA = N-acetyl-L-aspartate + CoA + H(+)." [EC:2.3.1.17, RHEA:14168]
synonym: "acetyl-CoA:L-aspartate N-acetyltransferase activity" EXACT [EC:2.3.1.17]
synonym: "aspartate acetyltransferase activity" EXACT [EC:2.3.1.17]
synonym: "L-aspartate N-acetyltransferase activity" EXACT [EC:2.3.1.17]
xref: EC:2.3.1.17
xref: KEGG:R00487
xref: MetaCyc:ASPARTATE-N-ACETYLTRANSFERASE-RXN
xref: RHEA:14168
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0017189
name: N-terminal peptidyl-alanine acetylation
namespace: biological_process
def: "The acetylation of the N-terminal alanine of proteins; catalyzed by peptide alpha-N-acetyltransferase or other enzymes of this class, such as ribosomal-protein-alanine N-acetyltransferase." [RESID:AA0041]
comment: See also the molecular function terms 'peptide alpha-N-acetyltransferase activity ; GO:0004596' and 'ribosomal-protein-alanine N-acetyltransferase activity ; GO:0008999'.
subset: gosubset_prok
xref: RESID:AA0041
is_a: GO:0006474 ! N-terminal protein amino acid acetylation
is_a: GO:0018194 ! peptidyl-alanine modification

[Term]
id: GO:0017190
name: N-terminal peptidyl-aspartic acid acetylation
namespace: biological_process
def: "The acetylation of the N-terminal aspartic acid of proteins; catalyzed by aspartate N-acetyltransferase." [RESID:AA0042]
comment: See also the molecular function term 'aspartate N-acetyltransferase activity ; GO:0017188'.
subset: gosubset_prok
xref: RESID:AA0042
is_a: GO:0006474 ! N-terminal protein amino acid acetylation
is_a: GO:0018197 ! peptidyl-aspartic acid modification

[Term]
id: GO:0017192
name: N-terminal peptidyl-glutamine acetylation
namespace: biological_process
def: "The acetylation of a glutamine residue in protein to form the N5-methyl-L-glutamine derivative. The occurrence of this modification has not been confirmed. Its annotation in sequence databases is either due to the misidentification of 2-pyrrolidone-5-carboxylic acid, or to inappropriate homolog comparisons when proteolytic modification is more probable." [RESID:AA0045]
subset: gosubset_prok
xref: RESID:AA0045
is_a: GO:0006474 ! N-terminal protein amino acid acetylation
is_a: GO:0018199 ! peptidyl-glutamine modification

[Term]
id: GO:0017193
name: N-terminal peptidyl-glycine acetylation
namespace: biological_process
def: "The acetylation of the N-terminal glycine of proteins to form the derivative N-acetylglycine." [RESID:AA0046]
subset: gosubset_prok
xref: RESID:AA0046
is_a: GO:0006474 ! N-terminal protein amino acid acetylation
is_a: GO:0018201 ! peptidyl-glycine modification

[Term]
id: GO:0017194
name: N-terminal peptidyl-isoleucine acetylation
namespace: biological_process
def: "The acetylation of the N-terminal isoleucine of proteins to form the derivative N-acetyl-L-isoleucine. The occurrence of this modification has not been confirmed." [RESID:AA0047]
subset: gosubset_prok
xref: RESID:AA0047
is_a: GO:0006474 ! N-terminal protein amino acid acetylation
is_a: GO:0018203 ! peptidyl-isoleucine modification

[Term]
id: GO:0017195
name: N-terminal peptidyl-lysine N2-acetylation
namespace: biological_process
def: "The acetylation of the N-terminal lysine of proteins to form the derivative N2-acetyl-L-lysine. The occurrence of this modification has not been confirmed." [RESID:AA0048]
subset: gosubset_prok
xref: RESID:AA0048
is_a: GO:0018076 ! N-terminal peptidyl-lysine acetylation

[Term]
id: GO:0017196
name: N-terminal peptidyl-methionine acetylation
namespace: biological_process
def: "The acetylation of the N-terminal methionine of proteins to form the derivative N-acetyl-L-methionine." [RESID:AA0049]
subset: gosubset_prok
xref: RESID:AA0049
is_a: GO:0006474 ! N-terminal protein amino acid acetylation
is_a: GO:0018206 ! peptidyl-methionine modification

[Term]
id: GO:0017197
name: N-terminal peptidyl-proline acetylation
namespace: biological_process
def: "The acetylation of the N-terminal proline of proteins to form the derivative N-acetyl-L-proline." [RESID:AA0050]
subset: gosubset_prok
xref: RESID:AA0050
is_a: GO:0006474 ! N-terminal protein amino acid acetylation
is_a: GO:0018208 ! peptidyl-proline modification

[Term]
id: GO:0017198
name: N-terminal peptidyl-serine acetylation
namespace: biological_process
def: "The acetylation of the N-terminal serine of proteins to form the derivative N-acetyl-L-serine." [RESID:AA0051]
subset: gosubset_prok
xref: RESID:AA0051
is_a: GO:0006474 ! N-terminal protein amino acid acetylation
is_a: GO:0018209 ! peptidyl-serine modification
is_a: GO:0030920 ! peptidyl-serine acetylation

[Term]
id: GO:0017199
name: N-terminal peptidyl-threonine acetylation
namespace: biological_process
def: "The acetylation of the N-terminal threonine of proteins to form the derivative N-acetyl-L-threonine; catalyzed by peptide alpha-N-acetyltransferase." [RESID:AA0052]
comment: See also the molecular function term 'peptide alpha-N-acetyltransferase activity ; GO:0004596'.
subset: gosubset_prok
xref: RESID:AA0052
is_a: GO:0006474 ! N-terminal protein amino acid acetylation
is_a: GO:0018210 ! peptidyl-threonine modification

[Term]
id: GO:0018000
name: N-terminal peptidyl-tyrosine acetylation
namespace: biological_process
def: "The acetylation of the N-terminal tyrosine of proteins to form the derivative N-acetyl-L-tyrosine." [RESID:AA0053]
subset: gosubset_prok
xref: RESID:AA0053
is_a: GO:0006474 ! N-terminal protein amino acid acetylation
is_a: GO:0018212 ! peptidyl-tyrosine modification

[Term]
id: GO:0018001
name: N-terminal peptidyl-valine acetylation
namespace: biological_process
def: "The acetylation of the N-terminal tyrosine of proteins to form the derivative N-acetyl-L-valine." [RESID:AA0054]
subset: gosubset_prok
xref: RESID:AA0054
is_a: GO:0006474 ! N-terminal protein amino acid acetylation
is_a: GO:0018213 ! peptidyl-valine modification

[Term]
id: GO:0018002
name: N-terminal peptidyl-glutamic acid acetylation
namespace: biological_process
def: "The acetylation of the N-terminal glutamic acid of proteins to form the derivate acetyl-glutamic acid." [RESID:AA0044]
comment: See also the molecular function term 'aspartate N-acetyltransferase activity ; GO:0017188'.
subset: gosubset_prok
xref: RESID:AA0044
is_a: GO:0006474 ! N-terminal protein amino acid acetylation
is_a: GO:0018200 ! peptidyl-glutamic acid modification

[Term]
id: GO:0018003
name: peptidyl-lysine N6-acetylation
namespace: biological_process
def: "The acetylation of the peptidyl-lysine of proteins to form the derivative peptidyl-N6-acetyl-L-lysine." [RESID:AA0055]
comment: See also the molecular function term 'tubulin N-acetyltransferase activity ; GO:0019799'.
subset: gosubset_prok
xref: RESID:AA0055
is_a: GO:0018393 ! internal peptidyl-lysine acetylation

[Term]
id: GO:0018004
name: N-terminal protein formylation
namespace: biological_process
def: "The formylation of the N-terminal amino acid of proteins." [GOC:ai]
subset: gosubset_prok
is_a: GO:0018256 ! protein formylation
is_a: GO:0031365 ! N-terminal protein amino acid modification

[Term]
id: GO:0018005
name: N-terminal peptidyl-glycine N-formylation
namespace: biological_process
def: "The formylation of the N-terminal glycine of proteins to form the derivative N-formylglycine." [RESID:AA0057]
subset: gosubset_prok
xref: RESID:AA0057
is_a: GO:0018004 ! N-terminal protein formylation
is_a: GO:0018201 ! peptidyl-glycine modification

[Term]
id: GO:0018006
name: N-terminal protein amino acid glucuronylation
namespace: biological_process
def: "The glucuronylation of the N-terminal amino acid of proteins." [GOC:ai]
subset: gosubset_prok
is_a: GO:0018321 ! protein glucuronylation
is_a: GO:0031365 ! N-terminal protein amino acid modification

[Term]
id: GO:0018007
name: N-terminal peptidyl-glycine N-glucuronylation
namespace: biological_process
def: "The glucuronylation of the N-terminal glycine of proteins to form the derivative D-glucuronyl-N-glycine." [RESID:AA0058]
subset: gosubset_prok
xref: RESID:AA0058
is_a: GO:0018006 ! N-terminal protein amino acid glucuronylation
is_a: GO:0018201 ! peptidyl-glycine modification

[Term]
id: GO:0018008
name: N-terminal peptidyl-glycine N-myristoylation
namespace: biological_process
def: "The myristoylation of the N-terminal glycine of proteins to form the derivative N-myristoyl-glycine." [RESID:AA0059]
subset: gosubset_prok
synonym: "N-terminal peptidyl-glycine N-myristylation" EXACT []
xref: RESID:AA0059
is_a: GO:0006499 ! N-terminal protein myristoylation
is_a: GO:0018201 ! peptidyl-glycine modification

[Term]
id: GO:0018009
name: N-terminal peptidyl-L-cysteine N-palmitoylation
namespace: biological_process
def: "The covalent attachment of a palmitoyl group to a nitrogen (N) atom in an N-terminal cysteine residue to form N-palmitoyl-L-cysteine." [RESID:AA0060]
subset: gosubset_prok
xref: RESID:AA0060
is_a: GO:0006500 ! N-terminal protein palmitoylation
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018010
name: glycoprotein N-palmitoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: palmitoyl-CoA + glycoprotein = CoA + N-palmitoylglycoprotein." [EC:2.3.1.96]
synonym: "mucus glycoprotein fatty acyltransferase" NARROW [EC:2.3.1.96]
synonym: "palmitoyl-CoA:glycoprotein N-palmitoyltransferase activity" EXACT [EC:2.3.1.96]
xref: EC:2.3.1.96
xref: MetaCyc:GLYCOPROTEIN-N-PALMITOYLTRANSFERASE-RXN
is_a: GO:0019105 ! N-palmitoyltransferase activity

[Term]
id: GO:0018011
name: N-terminal peptidyl-alanine methylation
namespace: biological_process
def: "The methylation of the N-terminal alanine of proteins." [RESID:AA0061, RESID:AA0062]
subset: gosubset_prok
xref: RESID:AA0061
xref: RESID:AA0062
is_a: GO:0006480 ! N-terminal protein amino acid methylation
is_a: GO:0018194 ! peptidyl-alanine modification

[Term]
id: GO:0018012
name: N-terminal peptidyl-alanine trimethylation
namespace: biological_process
def: "The trimethylation of the N-terminal alanine of proteins to form the derivative peptidyl-N,N,N-trimethyl-L-alanine." [RESID:AA0062]
subset: gosubset_prok
xref: RESID:AA0062
is_a: GO:0018011 ! N-terminal peptidyl-alanine methylation

[Term]
id: GO:0018013
name: N-terminal peptidyl-glycine methylation
namespace: biological_process
def: "The methylation of the N-terminal glycine of proteins to form the derivative N-methylglycine." [RESID:AA0063]
subset: gosubset_prok
xref: RESID:AA0063
is_a: GO:0006480 ! N-terminal protein amino acid methylation
is_a: GO:0018201 ! peptidyl-glycine modification

[Term]
id: GO:0018014
name: N-terminal peptidyl-methionine methylation
namespace: biological_process
def: "The methylation of the N-terminal methionine of proteins to form the derivative N-methyl-L-methionine." [RESID:AA0064]
subset: gosubset_prok
xref: RESID:AA0064
is_a: GO:0006480 ! N-terminal protein amino acid methylation
is_a: GO:0018206 ! peptidyl-methionine modification

[Term]
id: GO:0018015
name: N-terminal peptidyl-phenylalanine methylation
namespace: biological_process
def: "The methylation of the N-terminal phenylalanine of proteins to form the derivative N-methyl-L-phenylalanine." [RESID:AA0065]
subset: gosubset_prok
xref: RESID:AA0065
is_a: GO:0006480 ! N-terminal protein amino acid methylation
is_a: GO:0018207 ! peptidyl-phenylalanine modification

[Term]
id: GO:0018016
name: N-terminal peptidyl-proline dimethylation
namespace: biological_process
def: "The methylation of the N-terminal proline of proteins to form the derivative N,N-dimethyl-L-proline." [RESID:AA0066]
subset: gosubset_prok
xref: RESID:AA0066
is_a: GO:0035568 ! N-terminal peptidyl-proline methylation

[Term]
id: GO:0018019
name: N-terminal peptidyl-glutamine methylation
namespace: biological_process
def: "The methylation of a glutamine residue in proteins to form the peptidyl-N5-methyl-L-glutamine derivative." [RESID:AA0071]
subset: gosubset_prok
xref: RESID:AA0071
is_a: GO:0006480 ! N-terminal protein amino acid methylation
is_a: GO:0018199 ! peptidyl-glutamine modification

[Term]
id: GO:0018020
name: peptidyl-glutamic acid methylation
namespace: biological_process
def: "The addition of a methyl group to a glutamic acid residue in a protein." [GOC:mah]
subset: gosubset_prok
is_a: GO:0006479 ! protein methylation

[Term]
id: GO:0018021
name: peptidyl-histidine methylation
namespace: biological_process
def: "The methylation of peptidyl-L-histidine to form peptidyl-L-1'-methyl-L-histidine (otherwise known as tau-methylhistidine, tele-methylhistidine) or peptidyl-L-3'-methyl-L-histidine (otherwise known as pi-methylhistidine, pros-methylhistidine)." [RESID:AA0073, RESID:AA0317]
subset: gosubset_prok
xref: RESID:AA0073
xref: RESID:AA0317
is_a: GO:0006479 ! protein methylation
is_a: GO:0018202 ! peptidyl-histidine modification

[Term]
id: GO:0018022
name: peptidyl-lysine methylation
namespace: biological_process
def: "The methylation of peptidyl-lysine to form either the mono-, di- or trimethylated derivative." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006479 ! protein methylation
is_a: GO:0018205 ! peptidyl-lysine modification

[Term]
id: GO:0018023
name: peptidyl-lysine trimethylation
namespace: biological_process
def: "The methylation of peptidyl-lysine to form peptidyl-N6,N6,N6-trimethyl-L-lysine." [RESID:AA0074]
subset: gosubset_prok
xref: RESID:AA0074
is_a: GO:0018022 ! peptidyl-lysine methylation

[Term]
id: GO:0018024
name: histone-lysine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives." [EC:2.1.1.43, RESID:AA0074, RESID:AA0075, RESID:AA0076]
synonym: "histone H1-specific S-adenosylmethionine:protein-lysine N-methyltransferase activity" EXACT [EC:2.1.1.43]
synonym: "histone-lysine N-methylase activity" EXACT [GOC:mah]
synonym: "protein (lysine) methyltransferase activity" EXACT [EC:2.1.1.43]
synonym: "protein methylase 3 activity" NARROW [EC:2.1.1.43]
synonym: "protein methylase III activity" NARROW [EC:2.1.1.43]
synonym: "protein methyltransferase II activity" NARROW [EC:2.1.1.43]
synonym: "S-adenosyl-L-methionine:histone-L-lysine 6-N-methyltransferase activity" EXACT [EC:2.1.1.43]
synonym: "S-adenosyl-L-methionine:histone-L-lysine N6-methyltransferase activity" EXACT [EC:2.1.1.43]
xref: EC:2.1.1.43
xref: MetaCyc:HISTONE-LYSINE-N-METHYLTRANSFERASE-RXN
xref: RESID:AA0074
xref: RESID:AA0075
xref: RESID:AA0076
is_a: GO:0016279 ! protein-lysine N-methyltransferase activity
is_a: GO:0042054 ! histone methyltransferase activity
relationship: part_of GO:0034968 ! histone lysine methylation

[Term]
id: GO:0018025
name: calmodulin-lysine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + calmodulin L-lysine = S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine." [EC:2.1.1.60]
synonym: "S-adenosyl-L-methionine:calmodulin-L-lysine 6-N-methyltransferase activity" EXACT [EC:2.1.1.60]
synonym: "S-adenosyl-L-methionine:calmodulin-L-lysine N6-methyltransferase activity" EXACT [EC:2.1.1.60]
synonym: "S-adenosylmethionine:calmodulin (lysine) N-methyltransferase activity" EXACT [EC:2.1.1.60]
xref: EC:2.1.1.60
xref: MetaCyc:2.1.1.60-RXN
is_a: GO:0016279 ! protein-lysine N-methyltransferase activity

[Term]
id: GO:0018026
name: peptidyl-lysine monomethylation
namespace: biological_process
def: "The methylation of peptidyl-lysine to form peptidyl-N6-methyl-L-lysine." [RESID:AA0076]
subset: gosubset_prok
xref: RESID:AA0076
is_a: GO:0018022 ! peptidyl-lysine methylation

[Term]
id: GO:0018027
name: peptidyl-lysine dimethylation
namespace: biological_process
def: "The methylation of peptidyl-lysine to form peptidyl-N6,N6-dimethyl-L-lysine." [RESID:AA0075]
subset: gosubset_prok
xref: RESID:AA0075
is_a: GO:0018022 ! peptidyl-lysine methylation

[Term]
id: GO:0018028
name: peptidyl-lysine myristoylation
namespace: biological_process
def: "The myristoylation of peptidyl-lysine to form peptidyl-N6-myristoyl-L-lysine." [RESID:AA0078]
subset: gosubset_prok
synonym: "peptidyl-lysine myristylation" EXACT []
xref: RESID:AA0078
is_a: GO:0018205 ! peptidyl-lysine modification
is_a: GO:0018377 ! protein myristoylation

[Term]
id: GO:0018029
name: peptidyl-lysine palmitoylation
namespace: biological_process
def: "The palmitoylation of peptidyl-lysine to form peptidyl-N6-palmitoyl-L-lysine." [RESID:AA0077]
subset: gosubset_prok
xref: RESID:AA0077
is_a: GO:0018205 ! peptidyl-lysine modification

[Term]
id: GO:0018030
name: peptidyl-lysine N6-myristoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a myristoyl group to the N6 nitrogen atom on a lysine residue of a peptide or protein molecule." [GOC:mah]
xref: EC:2.3.1.-
is_a: GO:0019107 ! myristoyltransferase activity

[Term]
id: GO:0018031
name: peptidyl-lysine N6-palmitoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a palmitoyl group to the N6 nitrogen atom on a lysine residue of a peptide or protein molecule." [GOC:mah]
xref: EC:2.3.1.-
is_a: GO:0019105 ! N-palmitoyltransferase activity

[Term]
id: GO:0018032
name: protein amidation
namespace: biological_process
def: "Addition of an amide group from a glycine to a protein amino acid." [UniProtKB-KW:KW-0027]
subset: gosubset_prok
synonym: "protein amino acid amidation" EXACT [GOC:bf]
is_a: GO:0006464 ! cellular protein modification process

[Term]
id: GO:0018033
name: protein C-terminal amidation
namespace: biological_process
def: "The formation of a C-terminal amide by hydrolysis and oxidation of an interior peptide in a secreted protein." [GOC:ai]
subset: gosubset_prok
is_a: GO:0018032 ! protein amidation
is_a: GO:0018410 ! C-terminal protein amino acid modification

[Term]
id: GO:0018034
name: C-terminal peptidyl-alanine amidation
namespace: biological_process
def: "The formation of a C-terminal peptidyl-alanine amide by hydrolysis and oxidation of an interior Ala-Gly peptide in a secreted protein." [RESID:AA0081]
subset: gosubset_prok
xref: RESID:AA0081
is_a: GO:0018033 ! protein C-terminal amidation
is_a: GO:0018194 ! peptidyl-alanine modification

[Term]
id: GO:0018035
name: C-terminal peptidyl-arginine amidation
namespace: biological_process
def: "The formation of a C-terminal peptidyl-arginine amide by hydrolysis and oxidation of an interior Arg-Gly peptide in a secreted protein." [RESID:AA0082]
subset: gosubset_prok
xref: RESID:AA0082
is_a: GO:0018033 ! protein C-terminal amidation
is_a: GO:0018195 ! peptidyl-arginine modification

[Term]
id: GO:0018036
name: C-terminal peptidyl-asparagine amidation
namespace: biological_process
def: "The formation of a C-terminal peptidyl-asparagine amide by hydrolysis and oxidation of an interior Asn-Gly peptide in a secreted protein." [RESID:AA0083]
subset: gosubset_prok
xref: RESID:AA0083
is_a: GO:0018033 ! protein C-terminal amidation
is_a: GO:0018196 ! peptidyl-asparagine modification

[Term]
id: GO:0018037
name: C-terminal peptidyl-aspartic acid amidation
namespace: biological_process
def: "The formation of a C-terminal peptidyl-aspartic acid 1-amide by hydrolysis and oxidation of an interior Asp-Gly peptide in a secreted protein." [RESID:AA0084]
subset: gosubset_prok
xref: RESID:AA0084
is_a: GO:0018033 ! protein C-terminal amidation
is_a: GO:0018197 ! peptidyl-aspartic acid modification

[Term]
id: GO:0018038
name: C-terminal peptidyl-cysteine amidation
namespace: biological_process
def: "The formation of a C-terminal peptidyl-cysteine amide by hydrolysis and oxidation of an interior Cys-Gly peptide in a secreted protein." [RESID:AA0085]
subset: gosubset_prok
xref: RESID:AA0085
is_a: GO:0018033 ! protein C-terminal amidation
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018039
name: C-terminal peptidyl-glutamine amidation
namespace: biological_process
def: "The formation of a C-terminal peptidyl-glutamine amide by hydrolysis and oxidation of an interior Gln-Gly peptide in a secreted protein." [RESID:AA0086]
subset: gosubset_prok
xref: RESID:AA0086
is_a: GO:0018033 ! protein C-terminal amidation
is_a: GO:0018199 ! peptidyl-glutamine modification

[Term]
id: GO:0018040
name: C-terminal peptidyl-glutamic acid amidation
namespace: biological_process
def: "The formation of a C-terminal peptidyl-glutamic acid amide by hydrolysis and oxidation of an interior Glu-Gly peptide in a secreted protein." [RESID:AA0087]
subset: gosubset_prok
xref: RESID:AA0087
is_a: GO:0018033 ! protein C-terminal amidation

[Term]
id: GO:0018041
name: C-terminal peptidyl-glycine amidation
namespace: biological_process
def: "The formation of a C-terminal peptidyl-glycine acid amide by hydrolysis and oxidation of an interior Gly-Gly peptide in a secreted protein." [RESID:AA0088]
subset: gosubset_prok
xref: RESID:AA0088
is_a: GO:0018033 ! protein C-terminal amidation
is_a: GO:0018201 ! peptidyl-glycine modification

[Term]
id: GO:0018042
name: C-terminal peptidyl-histidine amidation
namespace: biological_process
def: "The formation of a C-terminal peptidyl-histidine amide by hydrolysis and oxidation of an interior His-Gly peptide in a secreted protein." [RESID:AA0089]
subset: gosubset_prok
xref: RESID:AA0089
is_a: GO:0018033 ! protein C-terminal amidation
is_a: GO:0018202 ! peptidyl-histidine modification

[Term]
id: GO:0018043
name: C-terminal peptidyl-isoleucine amidation
namespace: biological_process
def: "The formation of a C-terminal peptidyl-isoleucine amide by hydrolysis and oxidation of an interior Ile-Gly peptide in a secreted protein." [RESID:AA0090]
subset: gosubset_prok
xref: RESID:AA0090
is_a: GO:0018033 ! protein C-terminal amidation
is_a: GO:0018203 ! peptidyl-isoleucine modification

[Term]
id: GO:0018044
name: C-terminal peptidyl-leucine amidation
namespace: biological_process
def: "The formation of a C-terminal peptidyl-leucine amide by hydrolysis and oxidation of an interior Leu-Gly peptide in a secreted protein." [RESID:AA0091]
subset: gosubset_prok
xref: RESID:AA0091
is_a: GO:0018033 ! protein C-terminal amidation
is_a: GO:0018204 ! peptidyl-leucine modification

[Term]
id: GO:0018045
name: C-terminal peptidyl-lysine amidation
namespace: biological_process
def: "The formation of a C-terminal peptidyl-lysine amide by hydrolysis and oxidation of an interior Lys-Gly peptide in a secreted protein." [RESID:AA0092]
subset: gosubset_prok
xref: RESID:AA0092
is_a: GO:0018033 ! protein C-terminal amidation
is_a: GO:0018205 ! peptidyl-lysine modification

[Term]
id: GO:0018046
name: C-terminal peptidyl-methionine amidation
namespace: biological_process
def: "The formation of a C-terminal peptidyl-methionine amide by hydrolysis and oxidation of an interior Met-Gly peptide in a secreted protein." [RESID:AA0093]
subset: gosubset_prok
xref: RESID:AA0093
is_a: GO:0018033 ! protein C-terminal amidation
is_a: GO:0018206 ! peptidyl-methionine modification

[Term]
id: GO:0018047
name: C-terminal peptidyl-phenylalanine amidation
namespace: biological_process
def: "The formation of a C-terminal peptidyl-phenylalanine amide by hydrolysis and oxidation of an interior Phe-Gly peptide in a secreted protein." [RESID:AA0094]
subset: gosubset_prok
xref: RESID:AA0094
is_a: GO:0018033 ! protein C-terminal amidation
is_a: GO:0018207 ! peptidyl-phenylalanine modification

[Term]
id: GO:0018048
name: C-terminal peptidyl-proline amidation
namespace: biological_process
def: "The formation of a C-terminal peptidyl-proline amide by hydrolysis and oxidation of an interior Pro-Gly peptide in a secreted protein." [RESID:AA0095]
subset: gosubset_prok
xref: RESID:AA0095
is_a: GO:0018033 ! protein C-terminal amidation
is_a: GO:0018208 ! peptidyl-proline modification

[Term]
id: GO:0018049
name: C-terminal peptidyl-serine amidation
namespace: biological_process
def: "The formation of a C-terminal peptidyl-serine amide by hydrolysis and oxidation of an interior Ser-Gly peptide in a secreted protein." [RESID:AA0096]
subset: gosubset_prok
xref: RESID:AA0096
is_a: GO:0018033 ! protein C-terminal amidation
is_a: GO:0018209 ! peptidyl-serine modification

[Term]
id: GO:0018050
name: C-terminal peptidyl-threonine amidation
namespace: biological_process
def: "The formation of a C-terminal peptidyl-threonine amide by hydrolysis and oxidation of an interior Thr-Gly peptide in a secreted protein." [RESID:AA0097]
subset: gosubset_prok
xref: RESID:AA0097
is_a: GO:0018033 ! protein C-terminal amidation
is_a: GO:0018210 ! peptidyl-threonine modification

[Term]
id: GO:0018051
name: C-terminal peptidyl-tryptophan amidation
namespace: biological_process
def: "The formation of a C-terminal peptidyl-tryptophan amide by hydrolysis and oxidation of an interior Trp-Gly peptide in a secreted protein." [RESID:AA0098]
subset: gosubset_prok
xref: RESID:AA0098
is_a: GO:0018033 ! protein C-terminal amidation
is_a: GO:0018211 ! peptidyl-tryptophan modification

[Term]
id: GO:0018052
name: C-terminal peptidyl-tyrosine amidation
namespace: biological_process
def: "The formation of a C-terminal peptidyl-tyrosine amide by hydrolysis and oxidation of an interior Tyr-Gly peptide in a secreted protein." [RESID:AA0099]
subset: gosubset_prok
xref: RESID:AA0099
is_a: GO:0018033 ! protein C-terminal amidation
is_a: GO:0018212 ! peptidyl-tyrosine modification

[Term]
id: GO:0018053
name: C-terminal peptidyl-valine amidation
namespace: biological_process
def: "The formation of a C-terminal peptidyl-valine amide by hydrolysis and oxidation of an interior Val-Gly peptide in a secreted protein." [RESID:AA0100]
subset: gosubset_prok
xref: RESID:AA0100
is_a: GO:0018033 ! protein C-terminal amidation
is_a: GO:0018213 ! peptidyl-valine modification

[Term]
id: GO:0018054
name: peptidyl-lysine biotinylation
namespace: biological_process
def: "The covalent modification of peptidyl-lysine by biotin to form peptidyl-N6-biotinyl-L-lysine." [RESID:AA0117]
subset: gosubset_prok
xref: RESID:AA0117
is_a: GO:0009305 ! protein biotinylation
is_a: GO:0018205 ! peptidyl-lysine modification

[Term]
id: GO:0018055
name: peptidyl-lysine lipoylation
namespace: biological_process
def: "The lipoylation of peptidyl-lysine to form peptidyl-N6-lipoyl-L-lysine." [RESID:AA0118]
subset: gosubset_prok
xref: RESID:AA0118
is_a: GO:0009249 ! protein lipoylation
is_a: GO:0018205 ! peptidyl-lysine modification

[Term]
id: GO:0018057
name: peptidyl-lysine oxidation
namespace: biological_process
def: "The oxidation of the terminal amino-methylene groups of peptidyl-L-lysine or peptidyl-5-hydroxy-L-lysine to aldehyde groups to form allysine or hydroxyallysine residues, respectively; these are intermediates in the formation of covalent cross-links between adjacent polypeptide chains in proteins such as collagens." [ISBN:0198547684, RESID:AA0121]
subset: gosubset_prok
xref: RESID:AA0121
is_a: GO:0018158 ! protein oxidation
is_a: GO:0018205 ! peptidyl-lysine modification

[Term]
id: GO:0018058
name: N-terminal protein amino acid deamination, from amino carbon
namespace: biological_process
def: "The oxidative deamination of the alpha carbon of an encoded N-terminal amino acid, to form pyruvic acid retaining an amide bond between its 1-carboxyl group and the adjacent residue. The pyruvate 2-oxo group may become an enzyme active site, or it may be reduced to an alcohol." [RESID:AA0127, RESID:AA0128, RESID:AA0129]
subset: gosubset_prok
xref: RESID:AA0127
xref: RESID:AA0128
xref: RESID:AA0129
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018277 ! protein deamination
is_a: GO:0031363 ! N-terminal protein amino acid deamination

[Term]
id: GO:0018059
name: N-terminal peptidyl-serine deamination
namespace: biological_process
def: "The oxidative deamination of N-terminal peptidyl-serine to form pyruvic acid with an amide bond between its 1-carboxyl group and the N-terminal residue." [RESID:AA0127]
subset: gosubset_prok
is_a: GO:0018058 ! N-terminal protein amino acid deamination, from amino carbon

[Term]
id: GO:0018060
name: N-terminal peptidyl-cysteine deamination
namespace: biological_process
def: "The oxidative deamination of N-terminal peptidyl-cysteine to form pyruvic acid with an amide bond between its 1-carboxyl group and the N-terminal residue." [RESID:AA0127]
subset: gosubset_prok
is_a: GO:0018058 ! N-terminal protein amino acid deamination, from amino carbon

[Term]
id: GO:0018061
name: peptidyl-L-3-phenyllactic acid biosynthetic process from peptidyl-phenylalanine
namespace: biological_process
def: "The modification of a N-terminal peptidyl-phenylalanine residue by either oxidative deamination or by transamination and subsequent reduction to form peptidyl-L-3-phenyllactic acid." [RESID:AA0128]
subset: gosubset_prok
synonym: "peptidyl-L-3-phenyllactic acid anabolism from peptidyl-phenylalanine" EXACT []
synonym: "peptidyl-L-3-phenyllactic acid formation from peptidyl-phenylalanine" EXACT []
synonym: "peptidyl-L-3-phenyllactic acid synthesis from peptidyl-phenylalanine" EXACT []
xref: RESID:AA0128
is_a: GO:0018207 ! peptidyl-phenylalanine modification

[Term]
id: GO:0018062
name: peptidyl-tryptophan succinylation
namespace: biological_process
def: "The modification of an N-terminal peptidyl-tryptophan residue to form peptidyl-N2-succinyl-L-tryptophan." [RESID:AA0130]
subset: gosubset_prok
xref: RESID:AA0130
is_a: GO:0018211 ! peptidyl-tryptophan modification
is_a: GO:0018335 ! protein succinylation
is_a: GO:0031365 ! N-terminal protein amino acid modification

[Term]
id: GO:0018063
name: cytochrome c-heme linkage
namespace: biological_process
def: "The linkage of cytochromes and other heme proteins to heme." [RESID:AA0134, RESID:AA0135]
subset: gosubset_prok
synonym: "cytochrome c-haem linkage" EXACT []
xref: RESID:AA0134
xref: RESID:AA0135
is_a: GO:0017003 ! protein-heme linkage
is_a: GO:0017004 ! cytochrome complex assembly

[Term]
id: GO:0018064
name: protein-histidine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + protein L-histidine = S-adenosyl-L-homocysteine + protein N-methyl-L-histidine." [EC:2.1.1.85]
synonym: "actin-specific histidine methyltransferase activity" EXACT [EC:2.1.1.85]
synonym: "peptidyl-histidine N-methyltransferase activity" EXACT []
synonym: "protein (histidine) methyltransferase activity" EXACT [EC:2.1.1.85]
synonym: "protein methylase IV activity" NARROW [EC:2.1.1.85]
synonym: "S-adenosyl methionine:protein-histidine N-methyltransferase activity" EXACT [EC:2.1.1.85]
synonym: "S-adenosyl-L-methionine:protein-L-histidine N-tele-methyltransferase activity" EXACT [EC:2.1.1.85]
xref: EC:2.1.1.85
xref: MetaCyc:2.1.1.85-RXN
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0018065
name: protein-cofactor linkage
namespace: biological_process
def: "The covalent attachment of a cofactor to a protein." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006464 ! cellular protein modification process

[Term]
id: GO:0018067
name: peptidyl-L-3',4'-dihydroxyphenylalanine biosynthetic process from peptidyl-tyrosine
namespace: biological_process
def: "The modification of protein tyrosine to peptidyl-L-3',4'-dihydroxyphenylalanine (DOPA)." [RESID:AA0146]
subset: gosubset_prok
synonym: "peptidyl-L-3',4'-dihydroxyphenylalanine anabolism from peptidyl-tyrosine" EXACT []
synonym: "peptidyl-L-3',4'-dihydroxyphenylalanine formation from peptidyl-tyrosine" EXACT []
synonym: "peptidyl-L-3',4'-dihydroxyphenylalanine synthesis from peptidyl-tyrosine" EXACT []
xref: RESID:AA0146
is_a: GO:0018212 ! peptidyl-tyrosine modification
is_a: GO:0018336 ! peptidyl-tyrosine hydroxylation

[Term]
id: GO:0018068
name: peptidyl-L-2',4',5'-topaquinone biosynthetic process from peptidyl-tyrosine
namespace: biological_process
def: "The modification of protein tyrosine to L-2',4',5'-topaquinone, characteristic of the active site of copper amine oxidases." [RESID:AA0147]
subset: gosubset_prok
synonym: "peptidyl-L-2',4',5'-topaquinone anabolism from peptidyl-tyrosine" EXACT []
synonym: "peptidyl-L-2',4',5'-topaquinone formation from peptidyl-tyrosine" EXACT []
synonym: "peptidyl-L-2',4',5'-topaquinone synthesis from peptidyl-tyrosine" EXACT []
xref: RESID:AA0147
is_a: GO:0018212 ! peptidyl-tyrosine modification

[Term]
id: GO:0018069
name: peptide cross-linking via 4'-(L-tryptophan)-L-tryptophyl quinone
namespace: biological_process
def: "The cross-linking of a tryptophan residue to tryptophyl quinone to form 4'-(L-tryptophan)-L-tryptophyl quinone, a cofactor found at the active site of methylamine dehydrogenase." [RESID:AA0149]
subset: gosubset_prok
xref: RESID:AA0149
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018211 ! peptidyl-tryptophan modification

[Term]
id: GO:0018070
name: peptidyl-serine phosphopantetheinylation
namespace: biological_process
def: "The phosphopantetheinylation of peptidyl-serine to form peptidyl-O-phosphopantetheine-L-serine." [RESID:AA0150]
subset: gosubset_prok
xref: RESID:AA0150
is_a: GO:0018209 ! peptidyl-serine modification
is_a: GO:0018215 ! protein phosphopantetheinylation

[Term]
id: GO:0018071
name: NAD(P)-cysteine ADP-ribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(P)+ + L-cysteine = nicotinamide + N2-(ADP-D-ribosyl)-L-cysteine." [EC:2.4.2.-]
xref: EC:2.4.2.-
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0018072
name: peptidyl-L-glutamyl 5-glycerylphosphorylethanolamine biosynthetic process from peptidyl-glutamic acid
namespace: biological_process
def: "The modification of peptidyl-glutamic acid residues by the covalent attachment of ethanolamine, itself further modified by the addition of a phosphoglycerol unit." [PMID:2569467, RESID:AA0170]
subset: gosubset_prok
synonym: "peptidyl-L-glutamyl 5-glycerylphosphorylethanolamine anabolism from peptidyl-glutamic acid" EXACT []
synonym: "peptidyl-L-glutamyl 5-glycerylphosphorylethanolamine formation from peptidyl-glutamic acid" EXACT []
synonym: "peptidyl-L-glutamyl 5-glycerylphosphorylethanolamine synthesis from peptidyl-glutamic acid" EXACT []
xref: RESID:AA0170
is_a: GO:0018200 ! peptidyl-glutamic acid modification

[Term]
id: GO:0018073
name: protein bromination
namespace: biological_process
def: "The addition of one or more bromine atoms to an amino acid residue in a protein." [GOC:mah]
subset: gosubset_prok
synonym: "protein amino acid bromination" EXACT [GOC:bf]
is_a: GO:0018079 ! protein halogenation

[Term]
id: GO:0018074
name: peptidyl-histidine bromination
namespace: biological_process
def: "The bromination of peptidyl-histidine to form peptidyl-L-bromohistidine; the position of the bromine substitution is unknown." [RESID:AA0173]
subset: gosubset_prok
xref: RESID:AA0173
is_a: GO:0018073 ! protein bromination
is_a: GO:0018202 ! peptidyl-histidine modification

[Term]
id: GO:0018075
name: peptidyl-phenylalanine bromination
namespace: biological_process
def: "The bromination of phenylalanine." [RESID:AA0174, RESID:AA0175, RESID:AA0176]
subset: gosubset_prok
xref: RESID:AA0174
xref: RESID:AA0175
xref: RESID:AA0176
is_a: GO:0018073 ! protein bromination
is_a: GO:0018207 ! peptidyl-phenylalanine modification

[Term]
id: GO:0018076
name: N-terminal peptidyl-lysine acetylation
namespace: biological_process
def: "The acetylation of the N-terminal lysine of proteins." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006474 ! N-terminal protein amino acid acetylation
is_a: GO:0018394 ! peptidyl-lysine acetylation

[Term]
id: GO:0018077
name: protein iodination
namespace: biological_process
def: "The addition of one or more iodine atoms to an amino acid residue in a protein." [GOC:mah]
subset: gosubset_prok
synonym: "protein amino acid iodination" EXACT [GOC:bf]
is_a: GO:0018079 ! protein halogenation

[Term]
id: GO:0018078
name: peptidyl-thyronine iodination
namespace: biological_process
def: "The iodination of peptidyl-thyronine, formed from tyrosine." [RESID:AA0177, RESID:AA0178]
subset: gosubset_prok
xref: RESID:AA0177
xref: RESID:AA0178
is_a: GO:0018077 ! protein iodination
is_a: GO:0018212 ! peptidyl-tyrosine modification

[Term]
id: GO:0018079
name: protein halogenation
namespace: biological_process
def: "The addition of a halogen to a protein amino acid." [GOC:ai]
subset: gosubset_prok
synonym: "protein amino acid halogenation" EXACT [GOC:bf]
is_a: GO:0006464 ! cellular protein modification process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0070276 ! halogen metabolic process

[Term]
id: GO:0018080
name: peptidyl-tryptophan bromination
namespace: biological_process
def: "The bromination of peptidyl-tryptophan, to form peptidyl-L-6'-bromotryptophan." [RESID:AA0179]
subset: gosubset_prok
xref: RESID:AA0179
is_a: GO:0018073 ! protein bromination
is_a: GO:0018211 ! peptidyl-tryptophan modification

[Term]
id: GO:0018081
name: peptide cross-linking via lanthionine or 3-methyl-lanthionine
namespace: biological_process
def: "The synthesis of (2R,6R)-lanthionine, sn-(2S,6R)-lanthionine or (2S,3S,6R)-3-methyl-lanthionine, forming an intra-polypeptide cross-link between peptidyl-cysteine, and peptidyl-serine or peptidyl-threonine; dehydration of the serine or threonine residue to the alpha,beta-unsaturated amino acid is the first step; a bond then forms between the ethylene (ethene) group thus formed and the sulfur atom of a cysteine, with the inversion of the configuration of the alpha carbon of the serine or threonine occurring during the process." [ISBN:0198547684, RESID:AA0110, RESID:AA0111, RESID:AA0112]
subset: gosubset_prok
synonym: "peptide cross-linking via the thioethers lanthionine or 3-methyl-lanthionine" EXACT []
synonym: "peptide cross-linking via the thiolethers lanthionine or 3-methyl-lanthionine" EXACT []
xref: RESID:AA0110
xref: RESID:AA0111
xref: RESID:AA0112
is_a: GO:0018149 ! peptide cross-linking

[Term]
id: GO:0018082
name: peptidyl-(Z)-dehydrobutyrine biosynthetic process from peptidyl-threonine
namespace: biological_process
def: "The formation of (Z)-dehydrobutyrine by the dehydration of peptidyl-threonine." [RESID:AA0182]
subset: gosubset_prok
synonym: "peptidyl-(Z)-dehydrobutyrine anabolism from peptidyl-threonine" EXACT []
synonym: "peptidyl-(Z)-dehydrobutyrine formation from peptidyl-threonine" EXACT []
synonym: "peptidyl-(Z)-dehydrobutyrine synthesis from peptidyl-threonine" EXACT []
xref: RESID:AA0182
is_a: GO:0018210 ! peptidyl-threonine modification

[Term]
id: GO:0018083
name: peptidyl-L-3-oxoalanine biosynthetic process from peptidyl-cysteine or peptidyl-serine
namespace: biological_process
def: "The modification of peptidyl-cysteine or peptidyl-serine to peptidyl-L-3-oxoalanine; characteristic of the active sites of arylsulfatases." [RESID:AA0185]
subset: gosubset_prok
synonym: "peptidyl-L-3-oxoalanine anabolism from peptidyl-cysteine or peptidyl-serine" EXACT []
synonym: "peptidyl-L-3-oxoalanine formation from peptidyl-cysteine or peptidyl-serine" EXACT []
synonym: "peptidyl-L-3-oxoalanine synthesis from peptidyl-cysteine or peptidyl-serine" EXACT []
xref: RESID:AA0185
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018209 ! peptidyl-serine modification

[Term]
id: GO:0018084
name: peptidyl-lactic acid biosynthetic process from peptidyl-serine
namespace: biological_process
def: "The modification of N-terminal peptidyl-serine to lactic acid." [RESID:AA0186]
subset: gosubset_prok
synonym: "peptidyl-lactic acid anabolism from peptidyl-serine" EXACT []
synonym: "peptidyl-lactic acid formation from peptidyl-serine" EXACT []
synonym: "peptidyl-lactic acid synthesis from peptidyl-serine" EXACT []
xref: RESID:AA0186
is_a: GO:0018209 ! peptidyl-serine modification

[Term]
id: GO:0018085
name: peptidyl-L-amino acid racemization
namespace: biological_process
def: "The process of conversion of a L-amino acid into its enantiomer, the corresponding D-amino acid." [GOC:ma]
subset: gosubset_prok
is_a: GO:0018193 ! peptidyl-amino acid modification
is_a: GO:0018366 ! chiral amino acid racemization

[Term]
id: GO:0018086
name: obsolete alanine racemization
namespace: biological_process
alt_id: GO:0018368
def: "OBSOLETE (was not defined before being made obsolete)." [RESID:AA0191]
comment: This term was made obsolete because it was replaced with more appropriate terms.
synonym: "alanine racemization" EXACT []
is_obsolete: true
consider: GO:0019122

[Term]
id: GO:0018091
name: peptidyl-asparagine racemization
namespace: biological_process
alt_id: GO:0018373
alt_id: GO:0019127
def: "The racemization of peptidyl-asparagine." [RESID:AA0196]
subset: gosubset_prok
xref: RESID:AA0196
is_a: GO:0018085 ! peptidyl-L-amino acid racemization
is_a: GO:0018196 ! peptidyl-asparagine modification

[Term]
id: GO:0018094
name: protein polyglycylation
namespace: biological_process
def: "The addition of glycyl units covalently bound to the gamma carboxyl group peptidyl-glutamic acid." [RESID:AA0201]
subset: gosubset_prok
xref: RESID:AA0201
is_a: GO:0006464 ! cellular protein modification process

[Term]
id: GO:0018095
name: protein polyglutamylation
namespace: biological_process
def: "The addition of one or more alpha-linked glutamyl units to the gamma carboxyl group of peptidyl-glutamic acid." [RESID:AA0202]
subset: gosubset_prok
xref: RESID:AA0202
is_a: GO:0018200 ! peptidyl-glutamic acid modification

[Term]
id: GO:0018096
name: peptide cross-linking via S-(2-aminovinyl)-D-cysteine
namespace: biological_process
def: "The synthesis of (S,Z)-S-(2-aminovinyl)cysteine forming an intra-polypeptide cross-link between serine and cysteine." [RESID:AA0204]
subset: gosubset_prok
xref: RESID:AA0204
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018209 ! peptidyl-serine modification

[Term]
id: GO:0018097
name: protein-chromophore linkage via peptidyl-S-4-hydroxycinnamyl-L-cysteine
namespace: biological_process
def: "The synthesis of the chromophore S-4-hydroxycinnamyl-L-cysteine." [RESID:AA0207]
subset: gosubset_prok
synonym: "protein amino acid cinnamylation" BROAD []
xref: RESID:AA0207
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018298 ! protein-chromophore linkage

[Term]
id: GO:0018101
name: protein citrullination
namespace: biological_process
def: "The hydrolysis of peptidyl-arginine to form peptidyl-citrulline." [PMID:23175390, RESID:AA0214]
comment: Citrullination is distinct from the formation of the free amino acid citrulline (e.g. as part of the urea cycle).
subset: gosubset_prok
synonym: "deimination" EXACT [Wikipedia:Citrullination]
synonym: "peptidyl-citrulline anabolism from peptidyl-arginine" EXACT []
synonym: "peptidyl-citrulline biosynthetic process from peptidyl-arginine" EXACT [RESID:AA0214]
synonym: "peptidyl-citrulline formation from peptidyl-arginine" EXACT []
synonym: "peptidyl-citrulline synthesis from peptidyl-arginine" EXACT []
xref: RESID:AA0214
is_a: GO:0018195 ! peptidyl-arginine modification
is_a: GO:0019240 ! citrulline biosynthetic process

[Term]
id: GO:0018102
name: peptidyl-arginine hydroxylation to peptidyl-4-hydroxy-L-arginine
namespace: biological_process
def: "The hydroxylation of peptidyl-arginine to form peptidyl-4-hydroxy-L-arginine." [RESID:AA0215]
subset: gosubset_prok
xref: RESID:AA0215
is_a: GO:0018126 ! protein hydroxylation
is_a: GO:0030961 ! peptidyl-arginine hydroxylation

[Term]
id: GO:0018103
name: protein C-linked glycosylation
namespace: biological_process
def: "A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via a C atom." [GOC:pr, PMID:7947762, RESID:AA0217]
subset: gosubset_prok
synonym: "protein amino acid C-linked glycosylation" EXACT [GOC:bf]
xref: RESID:AA0217
is_a: GO:0006486 ! protein glycosylation

[Term]
id: GO:0018104
name: peptidoglycan-protein cross-linking
namespace: biological_process
def: "The process of covalently linking peptidoglycan (murein) to proteins." [GOC:jsg]
subset: gosubset_prok
is_a: GO:0009252 ! peptidoglycan biosynthetic process

[Term]
id: GO:0018105
name: peptidyl-serine phosphorylation
namespace: biological_process
def: "The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]
subset: gosubset_prok
xref: RESID:AA0037
is_a: GO:0006468 ! protein phosphorylation
is_a: GO:0018209 ! peptidyl-serine modification

[Term]
id: GO:0018106
name: peptidyl-histidine phosphorylation
namespace: biological_process
def: "The phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine)." [RESID:AA0035, RESID:AA0036]
subset: gosubset_prok
xref: RESID:AA0035
xref: RESID:AA0036
is_a: GO:0006468 ! protein phosphorylation
is_a: GO:0018202 ! peptidyl-histidine modification

[Term]
id: GO:0018107
name: peptidyl-threonine phosphorylation
namespace: biological_process
def: "The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [RESID:AA0038]
subset: gosubset_prok
xref: RESID:AA0038
is_a: GO:0006468 ! protein phosphorylation
is_a: GO:0018210 ! peptidyl-threonine modification

[Term]
id: GO:0018108
name: peptidyl-tyrosine phosphorylation
namespace: biological_process
def: "The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine." [RESID:AA0039]
subset: gosubset_prok
xref: RESID:AA0039
is_a: GO:0006468 ! protein phosphorylation
is_a: GO:0018212 ! peptidyl-tyrosine modification

[Term]
id: GO:0018109
name: peptidyl-arginine phosphorylation
namespace: biological_process
def: "The phosphorylation of peptidyl-arginine to form omega-N-phospho-L-arginine." [RESID:AA0222]
subset: gosubset_prok
xref: RESID:AA0222
is_a: GO:0006468 ! protein phosphorylation
is_a: GO:0018195 ! peptidyl-arginine modification

[Term]
id: GO:0018110
name: histone arginine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: histone L-arginine + ATP = histone N(omega)-phospho-L-arginine + ADP + 2 H(+)." [GOC:mah]
synonym: "histone-arginine kinase activity" EXACT []
xref: EC:2.7.3.-
is_a: GO:0004054 ! arginine kinase activity
is_a: GO:0035173 ! histone kinase activity
relationship: part_of GO:0018109 ! peptidyl-arginine phosphorylation

[Term]
id: GO:0018111
name: methionine racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-methionine = D-methionine." [EC:5.1.1.2, RHEA:12495]
xref: EC:5.1.1.2
xref: KEGG:R00655
xref: MetaCyc:METHIONINE-RACEMASE-RXN
xref: RHEA:12495
is_a: GO:0047661 ! amino-acid racemase activity

[Term]
id: GO:0018112
name: proline racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-proline = D-proline." [EC:5.1.1.4, RHEA:10683]
subset: gosubset_prok
xref: EC:5.1.1.4
xref: KEGG:R01255
xref: MetaCyc:PROLINE-RACEMASE-RXN
xref: RHEA:10683
is_a: GO:0047661 ! amino-acid racemase activity

[Term]
id: GO:0018113
name: lysine racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-lysine = D-lysine." [EC:5.1.1.5]
xref: EC:5.1.1.5
xref: MetaCyc:LYSINE-RACEMASE-RXN
xref: RHEA:22867
is_a: GO:0047661 ! amino-acid racemase activity

[Term]
id: GO:0018114
name: threonine racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-threonine = D-threonine." [EC:5.1.1.6, RHEA:13916]
xref: EC:5.1.1.6
xref: KEGG:R01467
xref: MetaCyc:THREONINE-RACEMASE-RXN
xref: RHEA:13916
is_a: GO:0047661 ! amino-acid racemase activity

[Term]
id: GO:0018115
name: peptidyl-S-diphytanylglycerol diether-L-cysteine biosynthetic process from peptidyl-cysteine
namespace: biological_process
def: "The modification of cysteine to form peptidyl-S-diphytanylglycerol diether-L-cysteine." [PMID:7797461, RESID:AA0223]
subset: gosubset_prok
synonym: "peptidyl-S-diphytanylglycerol diether-L-cysteine anabolism from peptidyl-cysteine" EXACT []
synonym: "peptidyl-S-diphytanylglycerol diether-L-cysteine formation from peptidyl-cysteine" EXACT []
synonym: "peptidyl-S-diphytanylglycerol diether-L-cysteine synthesis from peptidyl-cysteine" EXACT []
xref: RESID:AA0223
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018116
name: peptidyl-lysine adenylylation
namespace: biological_process
def: "The adenylylation of peptidyl-lysine to form peptidyl-N6-(phospho-5'-adenosine)-L-lysine." [RESID:AA0227]
subset: gosubset_prok
synonym: "peptidyl-lysine adenylation" EXACT []
xref: RESID:AA0227
is_a: GO:0018117 ! protein adenylylation
is_a: GO:0018205 ! peptidyl-lysine modification

[Term]
id: GO:0018117
name: protein adenylylation
namespace: biological_process
alt_id: GO:0018176
def: "The addition of an adenylyl group (adenosine 5'-monophosphate; AMP) to a protein amino acid." [GOC:ai, GOC:jsg, GOC:sart, PMID:21607083]
subset: gosubset_prok
synonym: "protein adenylation" EXACT []
synonym: "protein amino acid adenylylation" EXACT [GOC:bf]
synonym: "protein AMPylation" EXACT [GOC:jsg, GOC:sart, PMID:21607083]
is_a: GO:0018175 ! protein nucleotidylation

[Term]
id: GO:0018118
name: peptidyl-L-cysteine glutathione disulfide biosynthetic process from peptidyl-cysteine
namespace: biological_process
def: "The modification of peptidyl-cysteine by covalent addition of glutathione to form peptidyl-L-cysteine glutathione disulfide." [RESID:AA0229]
subset: gosubset_prok
synonym: "peptidyl-L-cysteine glutathione disulfide anabolism from peptidyl-cysteine" EXACT []
synonym: "peptidyl-L-cysteine glutathione disulfide formation from peptidyl-cysteine" EXACT []
synonym: "peptidyl-L-cysteine glutathione disulfide synthesis from peptidyl-cysteine" EXACT []
synonym: "peptidyl-L-cysteine glutathione disulphide biosynthesis from peptidyl-cysteine" EXACT []
synonym: "peptidyl-L-cysteine glutathione disulphide biosynthetic process from peptidyl-cysteine" EXACT []
xref: RESID:AA0229
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018119
name: peptidyl-cysteine S-nitrosylation
namespace: biological_process
def: "The covalent addition of a nitric oxide (NO) group to the sulphur (S) atom of a cysteine residue in a protein, to form peptidyl-S-nitrosyl-L-cysteine." [RESID:AA0230]
subset: gosubset_prok
synonym: "protein S-nitrosylation" EXACT [PMID:20972426]
synonym: "S-nitrosylation" EXACT [PMID:20972426]
xref: RESID:AA0230
is_a: GO:0017014 ! protein nitrosylation
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018120
name: peptidyl-arginine ADP-ribosylation
namespace: biological_process
def: "The transfer, from NAD, of ADP-ribose to peptidyl-arginine to form omega-N-(ADP-ribosyl)-L-arginine." [RESID:AA0168]
subset: gosubset_prok
xref: RESID:AA0168
is_a: GO:0006471 ! protein ADP-ribosylation
is_a: GO:0018195 ! peptidyl-arginine modification

[Term]
id: GO:0018121
name: NAD(P)-asparagine ADP-ribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(P)+ + L-asparagine = nicotinamide + N2-(ADP-D-ribosyl)-L-asparagine." [EC:2.4.2.-]
xref: EC:2.4.2.-
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0018122
name: peptidyl-asparagine ADP-ribosylation
namespace: biological_process
def: "The transfer, from NAD, of ADP-ribose to peptidyl-asparagine to form peptidyl-N4-(ADP-ribosyl)-L-asparagine." [RESID:AA0231]
subset: gosubset_prok
xref: RESID:AA0231
is_a: GO:0006471 ! protein ADP-ribosylation
is_a: GO:0018196 ! peptidyl-asparagine modification

[Term]
id: GO:0018123
name: peptidyl-cysteine ADP-ribosylation
namespace: biological_process
def: "The transfer, from NAD, of ADP-ribose to peptidyl-cysteine to form peptidyl-S-(ADP-ribosyl)-L-cysteine." [RESID:AA0169]
subset: gosubset_prok
xref: RESID:AA0169
is_a: GO:0006471 ! protein ADP-ribosylation
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018124
name: peptide cross-linking via 5'-(N6-L-lysine)-L-topaquinone
namespace: biological_process
def: "The cross-linking of the epsilon-amino group of a peptidyl-lysine with peptidyl-topaquinone, a modified tyrosine residue." [RESID:AA0233]
subset: gosubset_prok
xref: RESID:AA0233
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018205 ! peptidyl-lysine modification
is_a: GO:0018212 ! peptidyl-tyrosine modification

[Term]
id: GO:0018125
name: peptidyl-cysteine methylation
namespace: biological_process
def: "The methylation of peptidyl-cysteine to form peptidyl-S-methyl-L-cysteine." [RESID:AA0234]
subset: gosubset_prok
xref: RESID:AA0234
is_a: GO:0006479 ! protein methylation
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018126
name: protein hydroxylation
namespace: biological_process
def: "The addition of a hydroxy group to a protein amino acid." [GOC:ai]
subset: gosubset_prok
synonym: "protein amino acid hydroxylation" EXACT [GOC:bf]
is_a: GO:0006464 ! cellular protein modification process

[Term]
id: GO:0018127
name: NAD(P)-serine ADP-ribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(P)+ + L-serine = nicotinamide + N2-(ADP-D-ribosyl)-L-serine." [EC:2.4.2.-]
xref: EC:2.4.2.-
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0018128
name: obsolete peptidyl-serine cyclase activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because there is no record of why it was added, and no evidence can be found to suggest that this activity exists.
synonym: "peptidyl-serine cyclase activity" EXACT []
xref: EC:4.2.1.-
is_obsolete: true

[Term]
id: GO:0018129
name: peptidyl-oxazoline dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reduction of a peptide-linked oxazoline to oxazole." [GOC:mah, PMID:19058272]
xref: EC:1.3.-.-
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0018130
name: heterocycle biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [ISBN:0198547684]
subset: gosubset_prok
synonym: "heterocycle anabolism" EXACT []
synonym: "heterocycle biosynthesis" EXACT []
synonym: "heterocycle formation" EXACT []
synonym: "heterocycle synthesis" EXACT []
is_a: GO:0044249 ! cellular biosynthetic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0018131
name: oxazole or thiazole biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of oxazole or thiazole, five-membered heterocyclic ring structures containing an oxygen and a sulfur, respectively, in the 1-position and a nitrogen in the 3-position." [CHEBI:35790, CHEBI:48901, GOC:curators]
subset: gosubset_prok
synonym: "oxazole or thiazole anabolism" EXACT []
synonym: "oxazole or thiazole biosynthesis" EXACT []
synonym: "oxazole or thiazole formation" EXACT []
synonym: "oxazole or thiazole synthesis" EXACT []
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0046484 ! oxazole or thiazole metabolic process

[Term]
id: GO:0018132
name: peptide cross-linking via L-cysteine oxazolecarboxylic acid
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl cysteine cross-link by the condensation of a serine hydroxyl with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [PMID:8895467, RESID:AA0238]
subset: gosubset_prok
xref: RESID:AA0238
is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018209 ! peptidyl-serine modification
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0018133
name: peptide cross-linking via L-cysteine oxazolinecarboxylic acid
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl cysteine cross-link by the condensation of a serine hydroxyl with the carbonyl of the preceding residue." [RESID:AA0239]
subset: gosubset_prok
xref: RESID:AA0239
is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018209 ! peptidyl-serine modification
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0018134
name: peptide cross-linking via glycine oxazolecarboxylic acid
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl glycine cross-link by the condensation of a serine hydroxyl with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0240]
subset: gosubset_prok
xref: RESID:AA0240
is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole
is_a: GO:0018201 ! peptidyl-glycine modification
is_a: GO:0018209 ! peptidyl-serine modification
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0018135
name: obsolete peptidyl-cysteine cyclase activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because there is no record of why it was added, and no evidence can be found to suggest that this activity exists.
synonym: "peptidyl-cysteine cyclase activity" EXACT []
xref: EC:4.2.1.-
is_obsolete: true

[Term]
id: GO:0018136
name: peptidyl-thiazoline dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reduction of a peptide-linked thiazoline to thiazole." [GOC:mah, PMID:19058272]
xref: EC:1.3.-.-
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0018137
name: peptide cross-linking via glycine thiazolecarboxylic acid
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl glycine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0241]
subset: gosubset_prok
xref: RESID:AA0241
is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018201 ! peptidyl-glycine modification
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0018138
name: peptide cross-linking via L-serine thiazolecarboxylic acid
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl serine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0242]
subset: gosubset_prok
xref: RESID:AA0242
is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018209 ! peptidyl-serine modification
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0018139
name: peptide cross-linking via L-phenylalanine thiazolecarboxylic acid
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl phenylalanine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0243]
subset: gosubset_prok
xref: RESID:AA0243
is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018207 ! peptidyl-phenylalanine modification
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0018140
name: peptide cross-linking via L-cysteine thiazolecarboxylic acid
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl cysteine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0244]
subset: gosubset_prok
xref: RESID:AA0244
is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0018141
name: peptide cross-linking via L-lysine thiazolecarboxylic acid
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl lysine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0245]
subset: gosubset_prok
xref: RESID:AA0245
is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018205 ! peptidyl-lysine modification
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0018142
name: protein-DNA covalent cross-linking
namespace: biological_process
def: "The formation of a covalent cross-link between DNA and a protein." [GOC:ma]
subset: gosubset_prok
synonym: "DNA-protein covalent cross-linking" EXACT [GOC:mah]
is_a: GO:0018143 ! nucleic acid-protein covalent cross-linking

[Term]
id: GO:0018143
name: nucleic acid-protein covalent cross-linking
namespace: biological_process
def: "The formation of a covalent cross-link between a nucleic acid and a protein." [GOC:ma]
subset: gosubset_prok
is_a: GO:0006464 ! cellular protein modification process

[Term]
id: GO:0018144
name: RNA-protein covalent cross-linking
namespace: biological_process
def: "The formation of a covalent cross-link between RNA and a protein." [GOC:ma]
subset: gosubset_prok
is_a: GO:0018143 ! nucleic acid-protein covalent cross-linking

[Term]
id: GO:0018145
name: protein-DNA covalent cross-linking via peptidyl-serine
namespace: biological_process
def: "The formation of a covalent cross-link between DNA and a peptidyl-serine residue by the formation of O-(phospho-5'-DNA)-L-serine." [RESID:AA0246]
subset: gosubset_prok
synonym: "DNA-protein covalent cross-linking via peptidyl-serine" EXACT [GOC:mah]
xref: RESID:AA0246
is_a: GO:0018142 ! protein-DNA covalent cross-linking
is_a: GO:0018209 ! peptidyl-serine modification

[Term]
id: GO:0018146
name: keratan sulfate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues." [ISBN:0198547684, RESID:AA0247]
subset: gosubset_prok
synonym: "keratan sulfate anabolism" EXACT []
synonym: "keratan sulfate biosynthesis" EXACT []
synonym: "keratan sulfate formation" EXACT []
synonym: "keratan sulfate synthesis" EXACT []
synonym: "keratan sulphate biosynthesis" EXACT []
synonym: "keratan sulphate biosynthetic process" EXACT []
xref: RESID:AA0247
is_a: GO:0006024 ! glycosaminoglycan biosynthetic process
is_a: GO:0042339 ! keratan sulfate metabolic process
is_a: GO:0044272 ! sulfur compound biosynthetic process

[Term]
id: GO:0018147
name: molybdenum incorporation via L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide)
namespace: biological_process
def: "The incorporation of molybdenum into a protein via L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide)." [RESID:AA0248]
subset: gosubset_prok
xref: RESID:AA0248
is_a: GO:0018315 ! molybdenum incorporation into molybdenum-molybdopterin complex
is_a: GO:0050844 ! peptidyl-selenocysteine modification

[Term]
id: GO:0018148
name: RNA-protein covalent cross-linking via peptidyl-tyrosine
namespace: biological_process
def: "The formation of a covalent cross-link between RNA and a peptidyl-tyrosine residue by the formation of O4'-(phospho-5'-RNA)-L-tyrosine." [RESID:AA0249]
subset: gosubset_prok
xref: RESID:AA0249
is_a: GO:0018144 ! RNA-protein covalent cross-linking
is_a: GO:0018212 ! peptidyl-tyrosine modification

[Term]
id: GO:0018149
name: peptide cross-linking
namespace: biological_process
def: "The formation of a covalent cross-link between or within protein chains." [GOC:jsg]
subset: gosubset_prok
is_a: GO:0006464 ! cellular protein modification process

[Term]
id: GO:0018150
name: peptide cross-linking via 3-(3'-L-histidyl)-L-tyrosine
namespace: biological_process
def: "The modification of peptidyl-histidine and peptidyl-tyrosine to form a 3-(3'-L-histidyl)-L-tyrosine protein cross-link." [RESID:AA0250]
subset: gosubset_prok
xref: RESID:AA0250
is_a: GO:0018151 ! peptide cross-linking via L-histidyl-L-tyrosine

[Term]
id: GO:0018151
name: peptide cross-linking via L-histidyl-L-tyrosine
namespace: biological_process
def: "The modification of peptidyl-histidine and peptidyl-tyrosine to form a protein cross-link." [GOC:ai]
subset: gosubset_prok
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018202 ! peptidyl-histidine modification
is_a: GO:0018212 ! peptidyl-tyrosine modification

[Term]
id: GO:0018152
name: peptide cross-linking via 3'-(1'-L-histidyl)-L-tyrosine
namespace: biological_process
def: "The modification of peptidyl-histidine and peptidyl-tyrosine to form a 3'-(1'-L-histidyl)-L-tyrosine protein cross-link." [RESID:AA0270]
subset: gosubset_prok
xref: RESID:AA0270
is_a: GO:0018151 ! peptide cross-linking via L-histidyl-L-tyrosine

[Term]
id: GO:0018153
name: isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine
namespace: biological_process
def: "The formation of an isopeptide cross-link between peptidyl-lysine and peptidyl-glutamine to produce N6-(L-isoglutamyl)-L-lysine." [RESID:AA0124]
subset: gosubset_prok
xref: RESID:AA0124
is_a: GO:0018199 ! peptidyl-glutamine modification
is_a: GO:0018205 ! peptidyl-lysine modification
is_a: GO:0018262 ! isopeptide cross-linking

[Term]
id: GO:0018154
name: peptide cross-linking via (2R,6R)-lanthionine
namespace: biological_process
def: "The formation of a protein-protein cross-link between peptidyl-serine and peptidyl-cysteine by the synthesis of (2R,6R)-lanthionine (L-lanthionine)." [RESID:AA0110]
subset: gosubset_prok
xref: RESID:AA0110
is_a: GO:0018081 ! peptide cross-linking via lanthionine or 3-methyl-lanthionine
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018209 ! peptidyl-serine modification

[Term]
id: GO:0018155
name: peptide cross-linking via sn-(2S,6R)-lanthionine
namespace: biological_process
def: "The formation of a protein-protein cross-link between peptidyl-serine and peptidyl-cysteine by the synthesis of sn-(2S,6R)-lanthionine (meso-lanthione)." [RESID:AA0111]
subset: gosubset_prok
xref: RESID:AA0111
is_a: GO:0018081 ! peptide cross-linking via lanthionine or 3-methyl-lanthionine
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018209 ! peptidyl-serine modification

[Term]
id: GO:0018156
name: peptide cross-linking via (2S,3S,6R)-3-methyl-lanthionine
namespace: biological_process
def: "The formation of a protein-protein cross-link between peptidyl-threonine and peptidyl-cysteine by the synthesis of (2S,3S,6R)-3-methyl-lanthionine (3-methyl-L-lanthionine)." [RESID:AA0112]
subset: gosubset_prok
xref: RESID:AA0112
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018210 ! peptidyl-threonine modification

[Term]
id: GO:0018157
name: peptide cross-linking via an oxazole or thiazole
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl glycine, or peptidyl cysteine-peptidyl glycine cross-link by the condensation of the serine hydroxyl or cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [GOC:jsg]
subset: gosubset_prok
synonym: "peptide heterocycle biosynthesis" RELATED [GOC:mah]
synonym: "peptide heterocycle biosynthetic process" RELATED [GOC:mah]
synonym: "peptide heterocycle formation" RELATED [GOC:mah]
synonym: "peptide heterocycle synthesis" RELATED [GOC:mah]
is_a: GO:0018131 ! oxazole or thiazole biosynthetic process
is_a: GO:0018149 ! peptide cross-linking

[Term]
id: GO:0018158
name: protein oxidation
namespace: biological_process
def: "The modification of a protein amino acid by oxidation." [GOC:ai]
subset: gosubset_prok
synonym: "protein amino acid oxidation" EXACT [GOC:bf]
is_a: GO:0006464 ! cellular protein modification process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0055114 ! oxidation-reduction process

[Term]
id: GO:0018159
name: peptidyl-methionine oxidation
namespace: biological_process
def: "The oxidation of peptidyl-L-methionine to peptidyl-L-methionine sulfone." [RESID:AA0251]
subset: gosubset_prok
xref: RESID:AA0251
is_a: GO:0018158 ! protein oxidation
is_a: GO:0018206 ! peptidyl-methionine modification

[Term]
id: GO:0018160
name: peptidyl-pyrromethane cofactor linkage
namespace: biological_process
alt_id: GO:0018354
alt_id: GO:0033035
def: "The covalent binding of a pyrromethane (dipyrrin) cofactor to protein via the sulfur atom of cysteine forming dipyrrolylmethanemethyl-L-cysteine." [CHEBI:30410, RESID:AA0252]
subset: gosubset_prok
synonym: "dipyrromethane cofactor binding" RELATED [GOC:jsg]
synonym: "peptidyl-pyrromethane cofactor linkage via dipyrrolylmethanemethyl-L-cysteine" EXACT [GOC:jsg]
xref: RESID:AA0252
is_a: GO:0018065 ! protein-cofactor linkage
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018161
name: dipyrrin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dipyrrins (pyrromethanes), compounds containing two pyrrole rings linked through a methine, -CH=, group." [http://www.chem.qmw.ac.uk/iupac/class/tetpy.html#03]
subset: gosubset_prok
synonym: "dipyrrin anabolism" EXACT []
synonym: "dipyrrin biosynthesis" EXACT []
synonym: "dipyrrin formation" EXACT []
synonym: "dipyrrin synthesis" EXACT []
synonym: "dipyrromethane biosynthesis" EXACT []
synonym: "dipyrromethane biosynthetic process" EXACT []
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process
is_a: GO:0046453 ! dipyrrin metabolic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process

[Term]
id: GO:0018162
name: peptide cross-linking via S-(2-aminovinyl)-3-methyl-D-cysteine
namespace: biological_process
def: "The formation of a cross-link between peptidyl-cysteine and peptidyl-threonine via the formation of S-(2-aminovinyl)-3-methyl-D-cysteine." [RESID:AA0253]
subset: gosubset_prok
xref: RESID:AA0253
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018210 ! peptidyl-threonine modification

[Term]
id: GO:0018163
name: protein-DNA covalent cross-linking via the 5'-end to peptidyl-tyrosine
namespace: biological_process
def: "The formation of a covalent cross-link between DNA and a peptidyl-tyrosine residue by the formation of O4'-(phospho-5'-DNA)-L-tyrosine." [RESID:AA0254]
subset: gosubset_prok
synonym: "DNA-protein covalent cross-linking via the 5' end to peptidyl-tyrosine" EXACT [GOC:mah]
xref: RESID:AA0254
is_a: GO:0045327 ! protein-DNA covalent cross-linking via peptidyl-tyrosine

[Term]
id: GO:0018164
name: protein-DNA covalent cross-linking via peptidyl-threonine
namespace: biological_process
def: "The formation of a covalent cross-link between DNA and a peptidyl-threonine residue by the formation of O-(phospho-5'-DNA)-L-threonine." [RESID:AA0255]
subset: gosubset_prok
synonym: "DNA-protein covalent cross-linking via peptidyl-threonine" EXACT [GOC:mah]
xref: RESID:AA0255
is_a: GO:0018142 ! protein-DNA covalent cross-linking
is_a: GO:0018210 ! peptidyl-threonine modification

[Term]
id: GO:0018165
name: peptidyl-tyrosine uridylylation
namespace: biological_process
def: "The uridylylation of peptidyl-tyrosine to form peptidyl-O4'-(phospho-5'-uridine)-L-tyrosine, found in glutamine synthetase." [RESID:AA0256]
subset: gosubset_prok
xref: RESID:AA0256
is_a: GO:0018177 ! protein uridylylation
is_a: GO:0018212 ! peptidyl-tyrosine modification

[Term]
id: GO:0018166
name: C-terminal protein-tyrosinylation
namespace: biological_process
def: "The ATP-dependent addition of a tyrosine residue to the C-terminus of a protein; typically the addition of tyrosine to the C-terminus of detyrosinated alpha-tubulin by the enzyme tubulin-tyrosine ligase." [RESID:AA0257]
comment: See also the molecular function term 'tubulin-tyrosine ligase activity ; GO:0004835'.
subset: gosubset_prok
xref: RESID:AA0257
is_a: GO:0018212 ! peptidyl-tyrosine modification
is_a: GO:0018322 ! protein tyrosinylation
is_a: GO:0018410 ! C-terminal protein amino acid modification

[Term]
id: GO:0018167
name: protein-phycoerythrobilin linkage via phycoerythrobilin-bis-L-cysteine
namespace: biological_process
def: "The linkage of the chromophore phycoerythrobilin to phycoerythrin via phycoerythrobilin-bis-L-cysteine." [RESID:AA0259]
subset: gosubset_prok
xref: RESID:AA0259
is_a: GO:0017011 ! protein-phycoerythrobilin linkage
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018168
name: protein-phycoerythrobilin linkage via S-phycoerythrobilin-L-cysteine
namespace: biological_process
def: "The linkage of the chromophore phycoerythrobilin to phycoerythrocyanin via S-phycoerythrobilin-L-cysteine." [RESID:AA0132]
subset: gosubset_prok
xref: RESID:AA0132
is_a: GO:0017011 ! protein-phycoerythrobilin linkage
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018169
name: ribosomal S6-glutamic acid ligase activity
namespace: molecular_function
def: "Catalysis of the posttranslational transfer of one or more glutamic acid residues to the C-terminus of ribosomal protein S6." [GOC:mah, PMID:2570347]
xref: EC:6.3.2.-
is_a: GO:0070739 ! protein-glutamic acid ligase activity

[Term]
id: GO:0018170
name: C-terminal peptidyl-polyglutamic acid amidation
namespace: biological_process
def: "The formation of a C-terminal peptidyl-polyglutamic acid to form a peptidyl-N-L-glutamyl-poly-L-glutamic acid C-terminus." [RESID:AA0261]
subset: gosubset_prok
xref: RESID:AA0261
is_a: GO:0018040 ! C-terminal peptidyl-glutamic acid amidation
is_a: GO:0018200 ! peptidyl-glutamic acid modification

[Term]
id: GO:0018171
name: peptidyl-cysteine oxidation
namespace: biological_process
def: "The oxidation of peptidyl-cysteine to peptidyl-L-cysteine sulfinic acid or peptidyl-L-cysteine sulfenic acid." [PMID:9586994, RESID:AA0205, RESID:AA0262]
subset: gosubset_prok
xref: RESID:AA0205
xref: RESID:AA0262
is_a: GO:0018158 ! protein oxidation
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018172
name: peptidyl-L-3',4',5'-trihydroxyphenylalanine biosynthetic process from peptidyl-tyrosine
namespace: biological_process
def: "The modification of protein tyrosine to peptidyl-L-3',4',5'-dihydroxyphenylalanine." [RESID:AA0263]
subset: gosubset_prok
synonym: "peptidyl-L-3',4',5'-trihydroxyphenylalanine anabolism from peptidyl-tyrosine" EXACT []
synonym: "peptidyl-L-3',4',5'-trihydroxyphenylalanine formation from peptidyl-tyrosine" EXACT []
synonym: "peptidyl-L-3',4',5'-trihydroxyphenylalanine synthesis from peptidyl-tyrosine" EXACT []
xref: RESID:AA0263
is_a: GO:0018212 ! peptidyl-tyrosine modification
is_a: GO:0018336 ! peptidyl-tyrosine hydroxylation

[Term]
id: GO:0018173
name: peptidyl-1-thioglycine biosynthetic process from peptidyl-glycine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of peptidyl-1-thioglycine from other compounds, including peptidyl-glycine." [http://www.uni-marburg.de/mpi/thauer/thauer_res.html, RESID:AA0265]
subset: gosubset_prok
synonym: "peptidyl-1-thioglycine anabolism from peptidyl-glycine" EXACT []
synonym: "peptidyl-1-thioglycine formation from peptidyl-glycine" EXACT []
synonym: "peptidyl-1-thioglycine synthesis from peptidyl-glycine" EXACT []
xref: RESID:AA0265
is_a: GO:0018201 ! peptidyl-glycine modification
is_a: GO:0042398 ! cellular modified amino acid biosynthetic process
is_a: GO:0044249 ! cellular biosynthetic process
relationship: part_of GO:0015011 ! nickel-tetrapyrrole coenzyme metabolic process

[Term]
id: GO:0018174
name: protein-heme P460 linkage
namespace: biological_process
def: "The linkage of protein to heme P460." [RESID:AA0266, RESID:AA0271]
subset: gosubset_prok
synonym: "protein-haem P460 linkage" EXACT []
xref: RESID:AA0266
xref: RESID:AA0271
is_a: GO:0017003 ! protein-heme linkage
is_a: GO:0017004 ! cytochrome complex assembly

[Term]
id: GO:0018175
name: protein nucleotidylation
namespace: biological_process
def: "The addition of a nucleotide to a protein amino acid." [GOC:ai]
subset: gosubset_prok
synonym: "protein amino acid nucleotidylation" EXACT [GOC:bf]
is_a: GO:0006464 ! cellular protein modification process

[Term]
id: GO:0018177
name: protein uridylylation
namespace: biological_process
def: "The addition of phospho-uridine to a protein amino acid." [GOC:jsg]
subset: gosubset_prok
synonym: "protein amino acid uridylylation" EXACT [GOC:bf]
is_a: GO:0018175 ! protein nucleotidylation

[Term]
id: GO:0018178
name: peptidyl-threonine adenylylation
namespace: biological_process
def: "The adenylylation of peptidyl-threonine to form peptidyl-O-(phospho-5'-adenosine)-L-threonine." [RESID:AA0267]
subset: gosubset_prok
synonym: "peptidyl-threonine adenylation" EXACT []
xref: RESID:AA0267
is_a: GO:0018117 ! protein adenylylation
is_a: GO:0018210 ! peptidyl-threonine modification

[Term]
id: GO:0018179
name: obsolete peptidyl-cysteine desulfurization
namespace: biological_process
def: "OBSOLETE. The desulfurization of peptidyl-L-cysteine to yield L-alanine and elemental sulfur; peptidyl-L-cysteine persulfide is an intermediate." [RESID:AA0269]
comment: This term was made obsolete because to does not correspond to a real process.
subset: gosubset_prok
synonym: "peptidyl-cysteine desulfurization" EXACT []
synonym: "peptidyl-cysteine desulphurization" EXACT []
xref: RESID:AA0269
is_obsolete: true

[Term]
id: GO:0018180
name: protein desulfurization
namespace: biological_process
def: "The removal of a sulfur group from a protein amino acid." [GOC:ai]
subset: gosubset_prok
synonym: "protein amino acid desulfurisation" EXACT []
synonym: "protein amino acid desulfurization" EXACT [GOC:bf]
synonym: "protein amino acid desulphurisation" EXACT []
synonym: "protein amino acid desulphurization" EXACT []
is_a: GO:0006464 ! cellular protein modification process

[Term]
id: GO:0018181
name: peptidyl-arginine C5-methylation
namespace: biological_process
def: "The methylation of peptidyl-arginine on the carbon 5 (C5) residue to form peptidyl-5-methyl-L-arginine." [GOC:bf, http://www.uni-marburg.de/mpi/thauer/thauer_res.html, RESID:AA0272]
subset: gosubset_prok
synonym: "peptidyl-arginine 5-methylation" EXACT []
xref: RESID:AA0272
is_a: GO:0035245 ! peptidyl-arginine C-methylation

[Term]
id: GO:0018182
name: protein-heme linkage via 3'-L-histidine
namespace: biological_process
def: "The covalent linkage of heme and a protein via 3'-L-histidine (otherwise known as pi-heme-histidine, pros-heme-histidine)." [RESID:AA0276]
subset: gosubset_prok
synonym: "protein-haem linkage via 3'-L-histidine" EXACT []
xref: RESID:AA0276
is_a: GO:0017003 ! protein-heme linkage
is_a: GO:0018202 ! peptidyl-histidine modification

[Term]
id: GO:0018183
name: obsolete enzyme active site formation via S-selenyl-L-cysteine
namespace: biological_process
def: "OBSOLETE. The transient selenylation of peptidyl-cysteine to form S-selenyl-L-cysteine." [RESID:AA0277]
comment: This term was made obsolete because this structure does not exist.
synonym: "enzyme active site formation via S-selenyl-L-cysteine" EXACT []
is_obsolete: true

[Term]
id: GO:0018184
name: protein polyamination
namespace: biological_process
def: "The modification of a protein amino acid by polyamination." [GOC:ai]
subset: gosubset_prok
synonym: "protein amino acid polyamination" EXACT [GOC:bf]
is_a: GO:0006464 ! cellular protein modification process

[Term]
id: GO:0018185
name: poly-N-methyl-propylamination
namespace: biological_process
def: "The modification of peptidyl-lysine by the addition of an N6-propylamino and of propylmethylamino units, forming N6-(propylamino-poly(propylmethylamino)-propyldimethylamine)-L-lysine, typical of the silicate binding protein silaffin." [RESID:AA0278]
subset: gosubset_prok
xref: RESID:AA0278
is_a: GO:0018184 ! protein polyamination
is_a: GO:0018205 ! peptidyl-lysine modification

[Term]
id: GO:0018186
name: peroxidase-heme linkage
namespace: biological_process
def: "The covalent linkage of heme to peroxidase." [RESID:AA0279, RESID:AA0280]
subset: gosubset_prok
synonym: "peroxidase-haem linkage" EXACT []
xref: RESID:AA0279
xref: RESID:AA0280
is_a: GO:0017003 ! protein-heme linkage
is_a: GO:0017004 ! cytochrome complex assembly

[Term]
id: GO:0018187
name: molybdenum incorporation via L-cysteinyl molybdopterin guanine dinucleotide
namespace: biological_process
def: "The incorporation of molybdenum into a protein by L-cysteinyl molybdopterin guanine dinucleotide." [RESID:AA0281]
subset: gosubset_prok
xref: RESID:AA0281
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018315 ! molybdenum incorporation into molybdenum-molybdopterin complex

[Term]
id: GO:0018188
name: peptidyl-proline di-hydroxylation
namespace: biological_process
def: "The modification of peptidyl-proline to form trans-2,3-cis-3,4-dihydroxy-L-proline." [RESID:AA0282]
subset: gosubset_prok
xref: RESID:AA0282
is_a: GO:0019511 ! peptidyl-proline hydroxylation

[Term]
id: GO:0018189
name: pyrroloquinoline quinone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the cofactor pyrroloquinoline quinone (PQQ); it is synthesized from a small peptide containing tyrosine and glutamic acid; these amino acids in the peptide are multiply cross-linked and the rest of the peptide is removed." [PMID:7665488, RESID:AA0283]
subset: gosubset_prok
synonym: "coenzyme pyrroloquinoline-quinone biosynthesis" EXACT []
synonym: "coenzyme pyrroloquinoline-quinone biosynthetic process" EXACT []
synonym: "PQQ biosynthesis" EXACT []
synonym: "PQQ biosynthetic process" EXACT []
synonym: "pyrroloquinoline quinone anabolism" EXACT []
synonym: "pyrroloquinoline quinone biosynthesis" EXACT []
synonym: "pyrroloquinoline quinone formation" EXACT []
synonym: "pyrroloquinoline quinone synthesis" EXACT []
synonym: "pyrroloquinoline-quinone biosynthesis" EXACT []
synonym: "pyrroloquinoline-quinone biosynthetic process" EXACT []
xref: RESID:AA0283
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0018212 ! peptidyl-tyrosine modification
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process
is_a: GO:0072351 ! tricarboxylic acid biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process
is_a: GO:1901663 ! quinone biosynthetic process

[Term]
id: GO:0018190
name: protein octanoylation
namespace: biological_process
def: "The modification of a protein amino acid by formation of an ester or amide with octanoic acid." [GOC:jsg]
subset: gosubset_prok
synonym: "protein amino acid octanoylation" EXACT [GOC:bf]
is_a: GO:0006497 ! protein lipidation
is_a: GO:0043543 ! protein acylation

[Term]
id: GO:0018191
name: peptidyl-serine octanoylation
namespace: biological_process
def: "The octanoylation of peptidyl-serine to form peptidyl-O3-octanoyl-L-serine, typical of the protein ghrelin." [PMID:10604470, RESID:AA0290]
subset: gosubset_prok
xref: RESID:AA0290
is_a: GO:0018190 ! protein octanoylation
is_a: GO:0018209 ! peptidyl-serine modification

[Term]
id: GO:0018192
name: enzyme active site formation via cysteine modification to L-cysteine persulfide
namespace: biological_process
def: "The formation of an enzyme active site via modification of peptidyl-cysteine to peptidyl-L-cysteine persulfide." [PMID:11592406, RESID:AA0269]
subset: gosubset_prok
synonym: "enzyme active site formation via L-cysteine persulphide" EXACT []
is_a: GO:0018307 ! enzyme active site formation
is_a: GO:0098822 ! peptidyl-cysteine modification to L-cysteine persulfide

[Term]
id: GO:0018193
name: peptidyl-amino acid modification
namespace: biological_process
def: "The alteration of an amino acid residue in a peptide." [GOC:mah]
subset: goslim_yeast
subset: gosubset_prok
is_a: GO:0006464 ! cellular protein modification process

[Term]
id: GO:0018194
name: peptidyl-alanine modification
namespace: biological_process
def: "The modification of peptidyl-alanine." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018195
name: peptidyl-arginine modification
namespace: biological_process
def: "The modification of peptidyl-arginine." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018196
name: peptidyl-asparagine modification
namespace: biological_process
def: "The modification of peptidyl-asparagine." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018197
name: peptidyl-aspartic acid modification
namespace: biological_process
def: "The modification of peptidyl-aspartic acid." [GOC:ma]
subset: gosubset_prok
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018198
name: peptidyl-cysteine modification
namespace: biological_process
def: "The modification of peptidyl-cysteine." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018199
name: peptidyl-glutamine modification
namespace: biological_process
def: "The modification of peptidyl-glutamine." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018200
name: peptidyl-glutamic acid modification
namespace: biological_process
def: "The modification of peptidyl-glutamic acid." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018201
name: peptidyl-glycine modification
namespace: biological_process
def: "The modification of peptidyl-glycine." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018202
name: peptidyl-histidine modification
namespace: biological_process
def: "The modification of peptidyl-histidine." [GOC:ma]
subset: gosubset_prok
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018203
name: peptidyl-isoleucine modification
namespace: biological_process
def: "The modification of peptidyl-isoleucine." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018204
name: peptidyl-leucine modification
namespace: biological_process
def: "The modification of peptidyl-leucine." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018205
name: peptidyl-lysine modification
namespace: biological_process
def: "The modification of peptidyl-lysine." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018206
name: peptidyl-methionine modification
namespace: biological_process
def: "The modification of peptidyl-methionine." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018207
name: peptidyl-phenylalanine modification
namespace: biological_process
def: "The modification of peptidyl-phenylalanine." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018208
name: peptidyl-proline modification
namespace: biological_process
def: "The modification of peptidyl-proline." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018209
name: peptidyl-serine modification
namespace: biological_process
def: "The modification of peptidyl-serine." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018210
name: peptidyl-threonine modification
namespace: biological_process
def: "The modification of peptidyl-threonine." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018211
name: peptidyl-tryptophan modification
namespace: biological_process
def: "The chemical alteration of a tryptophan residue in a peptide." [GOC:isa_complete]
subset: gosubset_prok
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018212
name: peptidyl-tyrosine modification
namespace: biological_process
def: "The modification of peptidyl-tyrosine." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018213
name: peptidyl-valine modification
namespace: biological_process
def: "The modification of peptidyl-valine." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018214
name: protein carboxylation
namespace: biological_process
def: "The addition of a carboxy group to a protein amino acid." [GOC:ai]
subset: gosubset_prok
synonym: "protein amino acid carboxylation" EXACT [GOC:bf]
is_a: GO:0006464 ! cellular protein modification process

[Term]
id: GO:0018215
name: protein phosphopantetheinylation
namespace: biological_process
def: "The modification of a protein amino acid by phosphopantetheinylation." [GOC:ai]
subset: gosubset_prok
synonym: "protein amino acid phosphopantetheinylation" EXACT [GOC:bf]
is_a: GO:0006464 ! cellular protein modification process

[Term]
id: GO:0018216
name: peptidyl-arginine methylation
namespace: biological_process
alt_id: GO:0018017
def: "The addition of a methyl group to an arginine residue in a protein." [GOC:mah]
subset: gosubset_prok
is_a: GO:0006479 ! protein methylation
is_a: GO:0018195 ! peptidyl-arginine modification

[Term]
id: GO:0018217
name: peptidyl-aspartic acid phosphorylation
namespace: biological_process
def: "The phosphorylation of peptidyl-aspartic acid." [GOC:jl]
subset: gosubset_prok
is_a: GO:0006468 ! protein phosphorylation
is_a: GO:0018197 ! peptidyl-aspartic acid modification

[Term]
id: GO:0018218
name: peptidyl-cysteine phosphorylation
namespace: biological_process
def: "The phosphorylation of peptidyl-cysteine to form peptidyl-S-phospho-L-cysteine." [RESID:AA0034]
subset: gosubset_prok
xref: RESID:AA0034
is_a: GO:0006468 ! protein phosphorylation
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018219
name: peptidyl-cysteine S-acetylation
namespace: biological_process
def: "The acetylation of peptidyl-cysteine to form peptidyl-S-acetyl-L-cysteine." [RESID:AA0056]
subset: gosubset_prok
xref: RESID:AA0056
is_a: GO:0018533 ! peptidyl-cysteine acetylation

[Term]
id: GO:0018220
name: peptidyl-threonine palmitoylation
namespace: biological_process
def: "The covalent attachment of a palmitoyl group to an oxygen (O) atom in a threonine residue to form peptidyl-O-palmitoyl-L-threonine." [RESID:AA0079]
comment: Palmitoylation of a non-terminal threonine residue always occurs on an oxygen (O) atom.
subset: gosubset_prok
synonym: "peptidyl-threonine O-palmitoylation" EXACT [GOC:jsg]
xref: RESID:AA0079
is_a: GO:0018210 ! peptidyl-threonine modification
is_a: GO:0018345 ! protein palmitoylation

[Term]
id: GO:0018221
name: peptidyl-serine palmitoylation
namespace: biological_process
def: "The covalent attachment of a palmitoyl group to an oxygen (O) atom in a serine residue to form peptidyl-O-palmitoyl-L-serine." [RESID:AA0080]
comment: Palmitoylation of a non-terminal serine residue always occurs on an oxygen (O) atom.
subset: gosubset_prok
synonym: "peptidyl-serine O-palmitoylation" EXACT [GOC:jsg]
xref: RESID:AA0080
is_a: GO:0018209 ! peptidyl-serine modification
is_a: GO:0018345 ! protein palmitoylation

[Term]
id: GO:0018222
name: peptidyl-L-cysteine methyl disulfide biosynthetic process from peptidyl-cysteine
namespace: biological_process
def: "The modification of peptidyl-cysteine to form peptidyl-L-cysteine methyl disulfide." [RESID:AA0101]
subset: gosubset_prok
synonym: "peptidyl-L-cysteine methyl disulfide anabolism from peptidyl-cysteine" EXACT []
synonym: "peptidyl-L-cysteine methyl disulfide formation from peptidyl-cysteine" EXACT []
synonym: "peptidyl-L-cysteine methyl disulfide synthesis from peptidyl-cysteine" EXACT []
synonym: "peptidyl-L-cysteine methyl disulphide biosynthesis from peptidyl-cysteine" EXACT []
synonym: "peptidyl-L-cysteine methyl disulphide biosynthetic process from peptidyl-cysteine" EXACT []
xref: RESID:AA0101
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018226
name: peptidyl-S-farnesyl-L-cysteine biosynthetic process from peptidyl-cysteine
namespace: biological_process
def: "The modification of peptidyl-cysteine to form peptidyl-S-farnesyl-L-cysteine; formation of S-farnesycysteine may be coupled with subsequent cleavage of a carboxy-terminal tripeptide for the CXXX motif and methyl esterification of the farnesylated cysteine; the residue may be found at the first position in the sequence motif C-X-X-(SAQCMT)* where the second and third positions are usually aliphatic." [RESID:AA0102]
subset: gosubset_prok
synonym: "peptidyl-S-farnesyl-L-cysteine anabolism from peptidyl-cysteine" EXACT []
synonym: "peptidyl-S-farnesyl-L-cysteine formation from peptidyl-cysteine" EXACT []
synonym: "peptidyl-S-farnesyl-L-cysteine synthesis from peptidyl-cysteine" EXACT []
xref: RESID:AA0102
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018343 ! protein farnesylation

[Term]
id: GO:0018227
name: peptidyl-S-12-hydroxyfarnesyl-L-cysteine biosynthetic process from peptidyl-cysteine
namespace: biological_process
def: "The modification of peptidyl-cysteine to form S-12-hydroxyfarnesyl-L-cysteine; formation of S-farnesycysteine may be coupled with subsequent cleavage of a carboxy-terminal tripeptide for the CXXX motif and methyl esterification of the farnesylated cysteine." [RESID:AA0103]
subset: gosubset_prok
synonym: "peptidyl-S-12-hydroxyfarnesyl-L-cysteine anabolism from peptidyl-cysteine" EXACT []
synonym: "peptidyl-S-12-hydroxyfarnesyl-L-cysteine formation from peptidyl-cysteine" EXACT []
synonym: "peptidyl-S-12-hydroxyfarnesyl-L-cysteine synthesis from peptidyl-cysteine" EXACT []
xref: RESID:AA0103
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018343 ! protein farnesylation

[Term]
id: GO:0018228
name: peptidyl-S-geranylgeranyl-L-cysteine biosynthetic process from peptidyl-cysteine
namespace: biological_process
def: "The modification of peptidyl-cysteine to form peptidyl-S-geranylgeranylcysteine; formation of S-geranylgeranyl-L-cysteine may be coupled with subsequent cleavage of a carboxy-terminal tripeptide for the CAAX motif and methyl esterification of the geranylgeranylated cysteine; methyl esterification but not cleavage occurs for the CXC motif. For the type II geranylgeranyltransferase the residue may be found at the first and final positions in the sequence motif C-X-C* or at the final position in the sequence motif C-C*. These motifs are necessary but not sufficient for modification." [RESID:AA0104]
subset: gosubset_prok
synonym: "peptidyl-S-geranylgeranyl-L-cysteine anabolism from peptidyl-cysteine" EXACT []
synonym: "peptidyl-S-geranylgeranyl-L-cysteine formation from peptidyl-cysteine" EXACT []
synonym: "peptidyl-S-geranylgeranyl-L-cysteine synthesis from peptidyl-cysteine" EXACT []
xref: RESID:AA0104
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018344 ! protein geranylgeranylation

[Term]
id: GO:0018229
name: peptidyl-L-cysteine methyl ester biosynthetic process from peptidyl-cysteine
namespace: biological_process
def: "The modification of a C-terminal peptidyl-cysteine to form peptidyl-L-cysteine methyl ester." [RESID:AA0105]
synonym: "peptidyl-L-cysteine methyl ester anabolism from peptidyl-cysteine" EXACT []
synonym: "peptidyl-L-cysteine methyl ester formation from peptidyl-cysteine" EXACT []
synonym: "peptidyl-L-cysteine methyl ester synthesis from peptidyl-cysteine" EXACT []
xref: RESID:AA0105
is_a: GO:0006481 ! C-terminal protein methylation
is_a: GO:0018351 ! peptidyl-cysteine esterification

[Term]
id: GO:0018230
name: peptidyl-L-cysteine S-palmitoylation
namespace: biological_process
def: "The covalent attachment of a palmitoyl group to a sulfur (S) atom within a cysteine residue to form peptidyl-S-palmitoyl-L-cysteine." [RESID:AA0106]
comment: Palmitoylation of a non-terminal cysteine residue always occurs on a sulfur (S) atom.
subset: gosubset_prok
synonym: "peptidyl-cysteine S-palmitoylation" EXACT []
synonym: "peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine" EXACT []
synonym: "peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine" EXACT []
synonym: "peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine" EXACT []
synonym: "peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine" EXACT []
xref: RESID:AA0106
is_a: GO:0018231 ! peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine
is_a: GO:0018345 ! protein palmitoylation

[Term]
id: GO:0018231
name: peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine
namespace: biological_process
def: "The modification of peptidyl-cysteine to form peptidyl-S-diacylglycerol-L-cysteine; the oleate and palmitate actually represent mixtures of saturated (generally at 3') and unsaturated (generally at 2') fatty acids." [RESID:AA0107]
subset: gosubset_prok
synonym: "peptidyl-S-diacylglycerol-L-cysteine anabolism from peptidyl-cysteine" EXACT []
synonym: "peptidyl-S-diacylglycerol-L-cysteine formation from peptidyl-cysteine" EXACT []
synonym: "peptidyl-S-diacylglycerol-L-cysteine synthesis from peptidyl-cysteine" EXACT []
xref: RESID:AA0107
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018232
name: peptide cross-linking via S-(L-isoglutamyl)-L-cysteine
namespace: biological_process
def: "The modification of peptidyl-glutamine and peptidyl-cysteine to form a S-(L-isoglutamyl)-L-cysteine protein cross-link." [RESID:AA0108]
subset: gosubset_prok
xref: RESID:AA0108
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018199 ! peptidyl-glutamine modification

[Term]
id: GO:0018233
name: peptide cross-linking via 2'-(S-L-cysteinyl)-L-histidine
namespace: biological_process
def: "The modification of peptidyl-histidine and peptidyl-cysteine to form a 2'-(S-L-cysteinyl)-L-histidine protein cross-link." [RESID:AA0109]
subset: gosubset_prok
xref: RESID:AA0109
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018202 ! peptidyl-histidine modification

[Term]
id: GO:0018234
name: peptide cross-linking via 3'-(S-L-cysteinyl)-L-tyrosine
namespace: biological_process
def: "The thioether cross-linking of a cysteine residue to a tyrosine residue to form 3'-(S-L-cysteinyl)-L-tyrosine, found in galactose oxidase." [RESID:AA0113]
subset: gosubset_prok
xref: RESID:AA0113
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018212 ! peptidyl-tyrosine modification

[Term]
id: GO:0018235
name: peptidyl-lysine carboxylation
namespace: biological_process
def: "The modification of peptidyl-lysine to form peptidyl-N6-carboxy-L-lysine." [RESID:AA0114]
subset: gosubset_prok
xref: RESID:AA0114
is_a: GO:0018205 ! peptidyl-lysine modification
is_a: GO:0018214 ! protein carboxylation

[Term]
id: GO:0018237
name: urease activator activity
namespace: molecular_function
def: "Increases the activity of urease by promoting the incorporation of nickel into the active site." [GOC:mah, PMID:16244137]
synonym: "urease activase activity" EXACT []
is_a: GO:0008047 ! enzyme activator activity

[Term]
id: GO:0018238
name: peptidyl-lysine carboxyethylation
namespace: biological_process
alt_id: GO:0018239
def: "The modification of peptidyl-lysine to form peptidyl-N6-1-carboxyethyl-L-lysine." [RESID:AA0115]
subset: gosubset_prok
synonym: "protein amino acid carboxyethylation" EXACT []
xref: RESID:AA0115
is_a: GO:0018205 ! peptidyl-lysine modification

[Term]
id: GO:0018240
name: protein S-linked glycosylation via cysteine
namespace: biological_process
def: "The glycosylation of protein via the sulfur atom of peptidyl-cysteine, forming S-glycosyl-L-cysteine." [RESID:AA0152]
subset: gosubset_prok
synonym: "protein amino acid S-linked glycosylation via cysteine" EXACT [GOC:bf]
xref: RESID:AA0152
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018280 ! protein S-linked glycosylation

[Term]
id: GO:0018241
name: protein O-linked glycosylation via hydroxylysine
namespace: biological_process
def: "The glycosylation of protein via the O5 atom of peptidyl-hydroxylysine, forming O5-glycosyl-L-hydroxylysine; the most common form is galactosyl hydroxylysine." [RESID:AA0153]
subset: gosubset_prok
synonym: "protein amino acid O-linked glycosylation via hydroxylysine" EXACT [GOC:bf]
xref: RESID:AA0153
is_a: GO:0006493 ! protein O-linked glycosylation
is_a: GO:0018205 ! peptidyl-lysine modification

[Term]
id: GO:0018242
name: protein O-linked glycosylation via serine
namespace: biological_process
def: "The glycosylation of protein via the O3 atom of peptidyl-serine, forming O3-glycosyl-L-serine; the most common forms are N-acetylgalactosaminyl, mannosyl, galactosyl, and xylosyl serine." [RESID:AA0154]
subset: gosubset_prok
synonym: "protein amino acid O-linked glycosylation via serine" EXACT [GOC:bf]
xref: RESID:AA0154
is_a: GO:0006493 ! protein O-linked glycosylation
is_a: GO:0018209 ! peptidyl-serine modification

[Term]
id: GO:0018243
name: protein O-linked glycosylation via threonine
namespace: biological_process
def: "The glycosylation of protein via the O3 atom of peptidyl-threonine, forming O3-glycosyl-L-threonine; the most common forms are N-acetylgalactosaminyl, mannosyl, and galactosyl threonine." [RESID:AA0155]
subset: gosubset_prok
synonym: "protein amino acid O-linked glycosylation via threonine" EXACT [GOC:bf]
xref: RESID:AA0155
is_a: GO:0006493 ! protein O-linked glycosylation
is_a: GO:0018210 ! peptidyl-threonine modification

[Term]
id: GO:0018244
name: protein N-linked glycosylation via tryptophan
namespace: biological_process
def: "The glycosylation of protein via peptidyl-tryptophan, 1'-glycosyl-L-tryptophan; results in the formation of an (S)-2-amino-3-(1-D-mannopyranosyloxy-1H-indol-3-yl)propanoic acid residue." [RESID:AA0156]
subset: gosubset_prok
synonym: "protein amino acid N-linked glycosylation via tryptophan" EXACT [GOC:bf]
xref: RESID:AA0156
is_a: GO:0006487 ! protein N-linked glycosylation
is_a: GO:0018211 ! peptidyl-tryptophan modification

[Term]
id: GO:0018245
name: protein O-linked glycosylation via tyrosine
namespace: biological_process
def: "The glycosylation of protein via the O4' atom of peptidyl-tyrosine, O4'-glycosyl-L-tyrosine; the carbohydrate is glucose, the origin for glycogen." [RESID:AA0157]
subset: gosubset_prok
synonym: "protein amino acid O-linked glycosylation via tyrosine" EXACT [GOC:bf]
xref: RESID:AA0157
is_a: GO:0006493 ! protein O-linked glycosylation
is_a: GO:0018212 ! peptidyl-tyrosine modification

[Term]
id: GO:0018246
name: protein-coenzyme A linkage
namespace: biological_process
def: "The formation of a linkage between a protein amino acid and coenzyme A." [GOC:mah]
subset: gosubset_prok
is_a: GO:0018065 ! protein-cofactor linkage

[Term]
id: GO:0018247
name: protein-phosphoribosyl dephospho-coenzyme A linkage
namespace: biological_process
def: "The linkage of phosphoribosyl dephospho-coenzyme A to protein via peptidyl-serine, to form O-(phosphoribosyl dephospho-coenzyme A)-L-serine; it is uncertain whether the phosphoribosyl glycosidic attachment to the dephospho-coenzyme A is alpha or beta, and through the 2' or the 3' position." [RESID:AA0167]
subset: gosubset_prok
xref: RESID:AA0167
is_a: GO:0018209 ! peptidyl-serine modification
is_a: GO:0018246 ! protein-coenzyme A linkage

[Term]
id: GO:0018248
name: enzyme active site formation via peptidyl cysteine sulfation
namespace: biological_process
def: "The formation of an enzyme active site via transient sulfation of peptidyl-cysteine to form S-sulfo-L-cysteine." [RESID:AA0171]
subset: gosubset_prok
synonym: "enzyme active site formation via S-sulpho-L-cysteine" EXACT []
is_a: GO:0018307 ! enzyme active site formation
is_a: GO:0098824 ! petidyl-cysteine sulfation

[Term]
id: GO:0018249
name: protein dehydration
namespace: biological_process
def: "The removal of a water group from a protein amino acid." [GOC:ai]
subset: gosubset_prok
synonym: "protein amino acid dehydration" EXACT [GOC:bf]
is_a: GO:0006464 ! cellular protein modification process

[Term]
id: GO:0018250
name: peptidyl-dehydroalanine biosynthetic process from peptidyl-tyrosine or peptidyl-serine
namespace: biological_process
def: "The formation of peptidyl-dehydroalanine from either peptidyl-tyrosine by phenyl transfer, or from peptidyl-serine, which is coupled with the formation of 5-imidazolinone by the two neighboring residues, produces an 4-methylidene-imidazole-5-one active site of some amino acid ammonia-lyases; the 4-methylidene-imidazole-5-one, is formed autocatalytically by cyclization and dehydration of the sequence ASG." [RESID:AA0181]
subset: gosubset_prok
synonym: "peptidyl-dehydroalanine anabolism from peptidyl-tyrosine or peptidyl-serine" EXACT []
synonym: "peptidyl-dehydroalanine formation from peptidyl-tyrosine or peptidyl-serine" EXACT []
synonym: "peptidyl-dehydroalanine synthesis from peptidyl-tyrosine or peptidyl-serine" EXACT []
xref: RESID:AA0181
is_a: GO:0018194 ! peptidyl-alanine modification
is_a: GO:0018209 ! peptidyl-serine modification
is_a: GO:0018212 ! peptidyl-tyrosine modification
is_a: GO:0018249 ! protein dehydration
is_a: GO:0044249 ! cellular biosynthetic process
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0018251
name: peptidyl-tyrosine dehydrogenation
namespace: biological_process
def: "The oxidation of the C alpha-C beta bond of peptidyl-tyrosine to form peptidyl-dehydrotyrosine coupled with cyclization of neighboring residues." [RESID:AA0183]
comment: See also the biological process terms 'peptide cross-linking via L-seryl-5-imidazolinone glycine ; GO:0018252' and 'peptide cross-linking via 2-imino-glutaminyl-5-imidazolinone glycine ; GO:0019729'.
subset: gosubset_prok
xref: RESID:AA0183
is_a: GO:0018212 ! peptidyl-tyrosine modification
is_a: GO:0018249 ! protein dehydration

[Term]
id: GO:0018252
name: peptide cross-linking via L-seryl-5-imidazolinone glycine
namespace: biological_process
def: "The formation of the green fluorescent protein chromophore cross-link from the alpha-carboxyl carbon of residue n, a serine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons." [RESID:AA0184]
comment: See also the biological process term 'peptidyl-tyrosine dehydrogenation ; GO:0018251'.
synonym: "biosynthesis of protein-protein cross-link via L-seryl-5-imidazolinone glycine" EXACT []
synonym: "biosynthetic process of protein-protein cross-link via L-seryl-5-imidazolinone glycine" EXACT []
xref: RESID:AA0184
is_a: GO:0018209 ! peptidyl-serine modification
is_a: GO:0018253 ! peptide cross-linking via 5-imidazolinone glycine
is_a: GO:0018298 ! protein-chromophore linkage

[Term]
id: GO:0018253
name: peptide cross-linking via 5-imidazolinone glycine
namespace: biological_process
def: "The formation of a protein active site cross-link from the alpha-carboxyl carbon of residue n, an alanine, serine or cysteine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with an oxidation of residue n+1 to form an active aldehyde." [RESID:AA0184, RESID:AA0187, RESID:AA0188]
subset: gosubset_prok
synonym: "biosynthesis of protein-protein cross-link via 5-imidazolinone glycine" EXACT []
synonym: "biosynthetic process of protein-protein cross-link via 5-imidazolinone glycine" EXACT []
xref: RESID:AA0184
xref: RESID:AA0187
xref: RESID:AA0188
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018201 ! peptidyl-glycine modification

[Term]
id: GO:0018254
name: peptidyl-tyrosine adenylylation
namespace: biological_process
def: "The adenylylation of peptidyl-tyrosine to form peptidyl-O4'-(phospho-5'-adenosine)-L-tyrosine." [RESID:AA0203]
subset: gosubset_prok
synonym: "peptidyl-tyrosine adenylation" EXACT []
xref: RESID:AA0203
is_a: GO:0018117 ! protein adenylylation
is_a: GO:0018212 ! peptidyl-tyrosine modification

[Term]
id: GO:0018255
name: peptide cross-linking via S-glycyl-L-cysteine
namespace: biological_process
def: "The formation of S-(peptidyl-glycyl)-peptidyl-cysteine cross-links by the formation of a thiolester between cysteine and the carboxy-terminal glycine of ubiquitin and other proteins." [GOC:jh2, RESID:AA0206]
xref: RESID:AA0206
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018201 ! peptidyl-glycine modification

[Term]
id: GO:0018256
name: protein formylation
namespace: biological_process
def: "The addition of a formyl group to a protein amino acid." [GOC:ai]
subset: gosubset_prok
synonym: "protein amino acid formylation" EXACT [GOC:bf]
is_a: GO:0043543 ! protein acylation

[Term]
id: GO:0018257
name: peptidyl-lysine formylation
namespace: biological_process
def: "The modification of peptidyl-lysine to form peptidyl-N6-formyl-L-lysine." [RESID:AA0211]
subset: gosubset_prok
xref: RESID:AA0211
is_a: GO:0018205 ! peptidyl-lysine modification
is_a: GO:0018256 ! protein formylation

[Term]
id: GO:0018258
name: protein O-linked glycosylation via hydroxyproline
namespace: biological_process
def: "The glycosylation of proteins via 04 atom of hydroxyproline to form O4-glycosyl-L-hydroxyproline; the most common form is arabinofuranosyl-4-proline." [RESID:AA0212]
subset: gosubset_prok
synonym: "protein amino acid O-linked glycosylation via hydroxyproline" EXACT [GOC:bf]
xref: RESID:AA0212
is_a: GO:0006493 ! protein O-linked glycosylation
is_a: GO:0018208 ! peptidyl-proline modification

[Term]
id: GO:0018259
name: RNA-protein covalent cross-linking via peptidyl-serine
namespace: biological_process
def: "The formation of a covalent cross-link between RNA and a peptidyl-serine residue by the formation of O-(phospho-5'-5NA)-L-serine." [RESID:AA0213]
subset: gosubset_prok
xref: RESID:AA0213
is_a: GO:0018144 ! RNA-protein covalent cross-linking
is_a: GO:0018209 ! peptidyl-serine modification

[Term]
id: GO:0018260
name: protein guanylylation
namespace: biological_process
def: "The addition of phospho-guanosine to a protein amino acid." [GOC:ai]
subset: gosubset_prok
synonym: "protein amino acid guanylylation" EXACT [GOC:bf]
is_a: GO:0018175 ! protein nucleotidylation

[Term]
id: GO:0018261
name: peptidyl-lysine guanylylation
namespace: biological_process
def: "The guanylylation of peptidyl-lysine to form peptidyl-N6-(phospho-5'-guanosine)-L-lysine." [RESID:AA0228]
subset: gosubset_prok
xref: RESID:AA0228
is_a: GO:0018205 ! peptidyl-lysine modification
is_a: GO:0018260 ! protein guanylylation

[Term]
id: GO:0018262
name: isopeptide cross-linking
namespace: biological_process
def: "The formation of a covalent cross-link between or within peptide chains, where either the amino group or the carboxyl group, or both, are not attached to the alpha carbon." [GOC:jsg]
subset: gosubset_prok
is_a: GO:0018149 ! peptide cross-linking

[Term]
id: GO:0018263
name: isopeptide cross-linking via N-(L-isoaspartyl)-L-cysteine
namespace: biological_process
def: "The formation of an isopeptide cross-link between peptidyl-asparagine and peptidyl-cysteine to produce N-(L-isoaspartyl)-L-cysteine." [RESID:AA0216]
subset: gosubset_prok
xref: RESID:AA0216
is_a: GO:0018196 ! peptidyl-asparagine modification
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018262 ! isopeptide cross-linking

[Term]
id: GO:0018264
name: isopeptide cross-linking via N-(L-isoaspartyl)-glycine
namespace: biological_process
def: "The formation of an isopeptide cross-link between peptidyl-asparagine and peptidyl-glycine to produce N-(L-isoaspartyl)-glycine." [RESID:AA0126]
subset: gosubset_prok
xref: RESID:AA0126
is_a: GO:0018196 ! peptidyl-asparagine modification
is_a: GO:0018201 ! peptidyl-glycine modification
is_a: GO:0018262 ! isopeptide cross-linking

[Term]
id: GO:0018265
name: GPI anchor biosynthetic process via N-asparaginyl-glycosylphosphatidylinositolethanolamine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-asparagine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a asparaginyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0158]
subset: gosubset_prok
synonym: "GPI anchor anabolism via N-asparaginyl-glycosylphosphatidylinositolethanolamine" EXACT []
synonym: "GPI anchor formation via N-asparaginyl-glycosylphosphatidylinositolethanolamine" EXACT []
synonym: "GPI anchor synthesis via N-asparaginyl-glycosylphosphatidylinositolethanolamine" EXACT []
xref: RESID:AA0158
is_a: GO:0006506 ! GPI anchor biosynthetic process
is_a: GO:0018196 ! peptidyl-asparagine modification

[Term]
id: GO:0018266
name: GPI anchor biosynthetic process via N-aspartyl-glycosylphosphatidylinositolethanolamine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-aspartic acid ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a aspartyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0159]
subset: gosubset_prok
synonym: "GPI anchor anabolism via N-aspartyl-glycosylphosphatidylinositolethanolamine" EXACT []
synonym: "GPI anchor formation via N-aspartyl-glycosylphosphatidylinositolethanolamine" EXACT []
synonym: "GPI anchor synthesis via N-aspartyl-glycosylphosphatidylinositolethanolamine" EXACT []
xref: RESID:AA0159
is_a: GO:0006506 ! GPI anchor biosynthetic process
is_a: GO:0018197 ! peptidyl-aspartic acid modification

[Term]
id: GO:0018267
name: GPI anchor biosynthetic process via N-cysteinyl-glycosylphosphatidylinositolethanolamine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-cysteine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a cysteinyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0160]
subset: gosubset_prok
synonym: "GPI anchor anabolism via N-cysteinyl-glycosylphosphatidylinositolethanolamine" EXACT []
synonym: "GPI anchor formation via N-cysteinyl-glycosylphosphatidylinositolethanolamine" EXACT []
synonym: "GPI anchor synthesis via N-cysteinyl-glycosylphosphatidylinositolethanolamine" EXACT []
xref: RESID:AA0160
is_a: GO:0006506 ! GPI anchor biosynthetic process
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018268
name: GPI anchor biosynthetic process via N-glycyl-glycosylphosphatidylinositolethanolamine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-glycine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a glycyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0161]
subset: gosubset_prok
synonym: "GPI anchor anabolism via N-glycyl-glycosylphosphatidylinositolethanolamine" EXACT []
synonym: "GPI anchor formation via N-glycyl-glycosylphosphatidylinositolethanolamine" EXACT []
synonym: "GPI anchor synthesis via N-glycyl-glycosylphosphatidylinositolethanolamine" EXACT []
xref: RESID:AA0161
is_a: GO:0006506 ! GPI anchor biosynthetic process
is_a: GO:0018201 ! peptidyl-glycine modification

[Term]
id: GO:0018269
name: GPI anchor biosynthetic process via N-seryl-glycosylphosphatidylinositolethanolamine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-serine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a seryl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0162]
subset: gosubset_prok
synonym: "GPI anchor anabolism via N-seryl-glycosylphosphatidylinositolethanolamine" EXACT []
synonym: "GPI anchor formation via N-seryl-glycosylphosphatidylinositolethanolamine" EXACT []
synonym: "GPI anchor synthesis via N-seryl-glycosylphosphatidylinositolethanolamine" EXACT []
xref: RESID:AA0162
is_a: GO:0006506 ! GPI anchor biosynthetic process
is_a: GO:0018209 ! peptidyl-serine modification

[Term]
id: GO:0018270
name: GPI anchor biosynthetic process via N-alanyl-glycosylphosphatidylinositolethanolamine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-alanine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of an alanyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0163]
subset: gosubset_prok
synonym: "GPI anchor anabolism via N-alanyl-glycosylphosphatidylinositolethanolamine" EXACT []
synonym: "GPI anchor formation via N-alanyl-glycosylphosphatidylinositolethanolamine" EXACT []
synonym: "GPI anchor synthesis via N-alanyl-glycosylphosphatidylinositolethanolamine" EXACT []
xref: RESID:AA0163
is_a: GO:0006506 ! GPI anchor biosynthetic process
is_a: GO:0018194 ! peptidyl-alanine modification

[Term]
id: GO:0018271
name: biotin-protein ligase activity
namespace: molecular_function
alt_id: GO:0000106
def: "Catalysis of the reaction: ATP + biotin + protein = AMP + diphosphate + biotin-protein." [GOC:mah]
subset: gosubset_prok
synonym: "biotin-apoprotein ligase activity" EXACT []
xref: EC:6.3.4.-
xref: MetaCyc:BIOTINLIG-RXN
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0018272
name: protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine
namespace: biological_process
def: "The modification of peptidyl-lysine to form N6-pyridoxal phosphate-L-lysine." [RESID:AA0119]
subset: gosubset_prok
xref: RESID:AA0119
is_a: GO:0018205 ! peptidyl-lysine modification
is_a: GO:0018352 ! protein-pyridoxal-5-phosphate linkage

[Term]
id: GO:0018273
name: protein-chromophore linkage via peptidyl-N6-retinal-L-lysine
namespace: biological_process
def: "The modification of peptidyl-lysine to form N6-retinal-L-lysine." [RESID:AA0120]
subset: gosubset_prok
xref: RESID:AA0120
is_a: GO:0018205 ! peptidyl-lysine modification
is_a: GO:0018298 ! protein-chromophore linkage

[Term]
id: GO:0018274
name: peptide cross-linking via L-lysinoalanine
namespace: biological_process
def: "The modification of peptidyl-lysine and peptidyl-serine to form a (2Xi,9S)-L-lysinoalanine cross-link." [RESID:AA0123]
subset: gosubset_prok
xref: RESID:AA0123
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018205 ! peptidyl-lysine modification
is_a: GO:0018209 ! peptidyl-serine modification

[Term]
id: GO:0018275
name: N-terminal peptidyl-cysteine acetylation
namespace: biological_process
alt_id: GO:0017191
def: "The acetylation of the N-terminal cysteine of proteins to form the derivative N-acetyl-L-cysteine." [RESID:AA0043]
subset: gosubset_prok
synonym: "peptidyl-cysteine N-acetylation" EXACT []
xref: RESID:AA0043
is_a: GO:0006474 ! N-terminal protein amino acid acetylation
is_a: GO:0018533 ! peptidyl-cysteine acetylation

[Term]
id: GO:0018276
name: isopeptide cross-linking via N6-glycyl-L-lysine
namespace: biological_process
def: "The formation of an isopeptide cross-link between peptidyl-lysine and peptidyl-glycine to produce N6-glycyl-L-lysine. This is distinct from the formation of the thiolester intermediate, which occurs during ubiquitination." [RESID:AA0125]
comment: See also the biological process term 'peptide cross-linking via S-glycyl-L-cysteine ; GO:0018255'.
xref: RESID:AA0125
is_a: GO:0018201 ! peptidyl-glycine modification
is_a: GO:0018205 ! peptidyl-lysine modification
is_a: GO:0018262 ! isopeptide cross-linking
relationship: part_of GO:0016567 ! protein ubiquitination

[Term]
id: GO:0018277
name: protein deamination
namespace: biological_process
def: "The removal of an amino group from a protein amino acid." [GOC:ai]
subset: gosubset_prok
synonym: "protein amino acid deamination" EXACT [GOC:bf]
is_a: GO:0006464 ! cellular protein modification process

[Term]
id: GO:0018278
name: N-terminal peptidyl-threonine deamination
namespace: biological_process
def: "The deamination of N-terminal peptidyl-threonine to form peptidyl-2-oxobutanoic acid." [RESID:AA0129]
subset: gosubset_prok
xref: RESID:AA0129
is_a: GO:0018058 ! N-terminal protein amino acid deamination, from amino carbon
is_a: GO:0018210 ! peptidyl-threonine modification

[Term]
id: GO:0018279
name: protein N-linked glycosylation via asparagine
namespace: biological_process
def: "The glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine and N4 glucosyl asparagine also occur. This modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification." [GOC:jsg, RESID:AA0151, RESID:AA0420, RESID:AA0421]
subset: gosubset_prok
synonym: "protein amino acid N-linked glycosylation via asparagine" EXACT [GOC:bf]
xref: Reactome:REACT_101806 "Asparagine N-linked glycosylation, Taeniopygia guttata"
xref: Reactome:REACT_102423 "Synthesis of dolichyl-phosphate mannose, Dictyostelium discoideum"
xref: Reactome:REACT_103905 "Synthesis of dolichyl-phosphate-glucose, Rattus norvegicus"
xref: Reactome:REACT_105392 "Synthesis of dolichyl-phosphate mannose, Sus scrofa"
xref: Reactome:REACT_106089 "Asparagine N-linked glycosylation, Bos taurus"
xref: Reactome:REACT_106867 "Asparagine N-linked glycosylation, Schizosaccharomyces pombe"
xref: Reactome:REACT_107317 "Asparagine N-linked glycosylation, Caenorhabditis elegans"
xref: Reactome:REACT_107490 "Asparagine N-linked glycosylation, Oryza sativa"
xref: Reactome:REACT_109302 "Synthesis of dolichyl-phosphate-glucose, Sus scrofa"
xref: Reactome:REACT_2032 "Synthesis of dolichyl-phosphate mannose, Homo sapiens"
xref: Reactome:REACT_22346 "Synthesis of dolichyl-phosphate-glucose, Homo sapiens"
xref: Reactome:REACT_22426 "Asparagine N-linked glycosylation, Homo sapiens"
xref: Reactome:REACT_29000 "Asparagine N-linked glycosylation, Plasmodium falciparum"
xref: Reactome:REACT_31319 "Synthesis of dolichyl-phosphate-glucose, Schizosaccharomyces pombe"
xref: Reactome:REACT_31880 "Asparagine N-linked glycosylation, Saccharomyces cerevisiae"
xref: Reactome:REACT_33313 "Synthesis of dolichyl-phosphate-glucose, Xenopus tropicalis"
xref: Reactome:REACT_33428 "Asparagine N-linked glycosylation, Canis familiaris"
xref: Reactome:REACT_34542 "Synthesis of dolichyl-phosphate mannose, Xenopus tropicalis"
xref: Reactome:REACT_49533 "Asparagine N-linked glycosylation, Rattus norvegicus"
xref: Reactome:REACT_77477 "Asparagine N-linked glycosylation, Mus musculus"
xref: Reactome:REACT_78147 "Synthesis of dolichyl-phosphate mannose, Canis familiaris"
xref: Reactome:REACT_79719 "Asparagine N-linked glycosylation, Sus scrofa"
xref: Reactome:REACT_79897 "Synthesis of dolichyl-phosphate-glucose, Drosophila melanogaster"
xref: Reactome:REACT_79977 "Synthesis of dolichyl-phosphate-glucose, Danio rerio"
xref: Reactome:REACT_80262 "Asparagine N-linked glycosylation, Danio rerio"
xref: Reactome:REACT_80926 "Asparagine N-linked glycosylation, Xenopus tropicalis"
xref: Reactome:REACT_81194 "Synthesis of dolichyl-phosphate mannose, Danio rerio"
xref: Reactome:REACT_82378 "Synthesis of dolichyl-phosphate-glucose, Canis familiaris"
xref: Reactome:REACT_82580 "Synthesis of dolichyl-phosphate-glucose, Bos taurus"
xref: Reactome:REACT_82685 "Synthesis of dolichyl-phosphate-glucose, Oryza sativa"
xref: Reactome:REACT_84186 "Synthesis of dolichyl-phosphate mannose, Bos taurus"
xref: Reactome:REACT_87172 "Asparagine N-linked glycosylation, Gallus gallus"
xref: Reactome:REACT_87887 "Synthesis of dolichyl-phosphate-glucose, Mus musculus"
xref: Reactome:REACT_88885 "Synthesis of dolichyl-phosphate mannose, Mus musculus"
xref: Reactome:REACT_89649 "Synthesis of dolichyl-phosphate-glucose, Saccharomyces cerevisiae"
xref: Reactome:REACT_90382 "Synthesis of dolichyl-phosphate-glucose, Taeniopygia guttata"
xref: Reactome:REACT_90624 "Asparagine N-linked glycosylation, Dictyostelium discoideum"
xref: Reactome:REACT_93759 "Synthesis of dolichyl-phosphate-glucose, Caenorhabditis elegans"
xref: Reactome:REACT_94271 "Asparagine N-linked glycosylation, Arabidopsis thaliana"
xref: Reactome:REACT_94975 "Synthesis of dolichyl-phosphate-glucose, Dictyostelium discoideum"
xref: Reactome:REACT_97528 "Asparagine N-linked glycosylation, Drosophila melanogaster"
xref: Reactome:REACT_98125 "Synthesis of dolichyl-phosphate-glucose, Gallus gallus"
xref: Reactome:REACT_99301 "Synthesis of dolichyl-phosphate-glucose, Arabidopsis thaliana"
is_a: GO:0006487 ! protein N-linked glycosylation
is_a: GO:0018196 ! peptidyl-asparagine modification

[Term]
id: GO:0018280
name: protein S-linked glycosylation
namespace: biological_process
def: "A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via a sulfur atom of a peptidyl-amino-acid such as cysteine or methionine." [GOC:ai, GOC:jsg, GOC:pr]
subset: gosubset_prok
synonym: "protein amino acid S-linked glycosylation" EXACT [GOC:bf]
is_a: GO:0006486 ! protein glycosylation

[Term]
id: GO:0018281
name: GSI anchor biosynthetic process via N-seryl-glycosylsphingolipidinositolethanolamine
namespace: biological_process
def: "The formation of a C-terminal peptidyl-serine ethanolamide-linked glycosylsphingolipidinositol (GSI) anchor following hydrolysis of a seryl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0166]
subset: gosubset_prok
synonym: "GSI anchor anabolism via N-seryl-glycosylsphingolipidinositolethanolamine" EXACT []
synonym: "GSI anchor formation via N-seryl-glycosylsphingolipidinositolethanolamine" EXACT []
synonym: "GSI anchor synthesis via N-seryl-glycosylsphingolipidinositolethanolamine" EXACT []
xref: RESID:AA0166
is_a: GO:0018209 ! peptidyl-serine modification
is_a: GO:0042082 ! GSI anchor biosynthetic process

[Term]
id: GO:0018282
name: metal incorporation into metallo-sulfur cluster
namespace: biological_process
def: "The formation of a cluster of several metal atoms, including iron, nickel, molybdenum, vanadium, or copper, with one or more bridging (mu-bond) sulfur atoms; amino acids residues in proteins that may ligate the metal sulfur cluster are cysteine, histidine, aspartate, glutamate, serine and cysteine persulfide." [GOC:jsg]
subset: gosubset_prok
synonym: "metal incorporation into metallo-sulphur cluster" EXACT []
is_a: GO:0006464 ! cellular protein modification process
relationship: part_of GO:0031163 ! metallo-sulfur cluster assembly

[Term]
id: GO:0018283
name: iron incorporation into metallo-sulfur cluster
namespace: biological_process
def: "The incorporation of iron into a metallo-sulfur cluster." [GOC:ai]
subset: gosubset_prok
synonym: "iron incorporation into metallo-sulphur cluster" EXACT []
is_a: GO:0016226 ! iron-sulfur cluster assembly
is_a: GO:0018282 ! metal incorporation into metallo-sulfur cluster

[Term]
id: GO:0018284
name: iron incorporation into protein via tetrakis-L-cysteinyl iron
namespace: biological_process
def: "The incorporation of iron into a protein via tetrakis-L-cysteinyl iron (there is no exogenous sulfur, so this modification by itself does not produce an iron-sulfur protein)." [RESID:AA0136]
subset: gosubset_prok
xref: RESID:AA0136
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0018285
name: iron incorporation into iron-sulfur cluster via tetrakis-L-cysteinyl diiron disulfide
namespace: biological_process
def: "The incorporation of iron into a 2Fe-2S iron-sulfur cluster via tetrakis-L-cysteinyl diiron disulfide." [RESID:AA0137]
subset: gosubset_prok
synonym: "iron incorporation into iron-sulphur cluster via tetrakis-L-cysteinyl diiron disulphide" EXACT []
xref: RESID:AA0137
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0018286
name: obsolete iron incorporation into iron-sulfur cluster via hexakis-L-cysteinyl triiron trisulfide
namespace: biological_process
def: "OBSOLETE. The incorporation of iron into a 3Fe-3S iron-sulfur cluster via hexakis-L-cysteinyl triiron trisulfide. The three-iron three-sulfur cluster probably does not exist except as an intermediate form." [RESID:AA0138]
comment: This term was made obsolete because the three-iron three-sulfur cluster is now thought not to exist except possibly as an intermediate form.
synonym: "iron incorporation into iron-sulfur cluster via hexakis-L-cysteinyl triiron trisulfide" EXACT []
synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl triiron trisulphide" EXACT []
is_obsolete: true
consider: GO:0018198
consider: GO:0018283

[Term]
id: GO:0018287
name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl triiron tetrasulfide
namespace: biological_process
def: "The incorporation of iron into a 3Fe-4S iron-sulfur cluster via tris-L-cysteinyl triiron tetrasulfide." [RESID:AA0139]
subset: gosubset_prok
synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl triiron tetrasulphide" EXACT []
xref: RESID:AA0139
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0018288
name: iron incorporation into iron-sulfur cluster via tetrakis-L-cysteinyl tetrairon tetrasulfide
namespace: biological_process
def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tetrakis-L-cysteinyl tetrairon tetrasulfide." [RESID:AA0140]
subset: gosubset_prok
synonym: "iron incorporation into iron-sulphur cluster via tetrakis-L-cysteinyl tetrairon tetrasulphide" EXACT []
xref: RESID:AA0140
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0018289
name: molybdenum incorporation into metallo-sulfur cluster
namespace: biological_process
def: "The incorporation of molybdenum into a metallo-sulfur cluster." [GOC:ai]
subset: gosubset_prok
synonym: "molybdenum incorporation into metallo-sulphur cluster" EXACT []
is_a: GO:0018282 ! metal incorporation into metallo-sulfur cluster

[Term]
id: GO:0018290
name: iron and molybdenum incorporation into iron-molybdenum-sulfur cluster via L-cysteinyl homocitryl molybdenum-heptairon-nonasulfide
namespace: biological_process
def: "The incorporation of iron and molybdenum into a Mo-7Fe-8S iron-molybdenum-sulfur cluster via L-cysteinyl homocitryl molybdenum-heptairon-nonasulfide, found in nitrogenase." [RESID:AA0141]
subset: gosubset_prok
synonym: "iron and molybdenum incorporation into iron-molybdenum-sulphur cluster via L-cysteinyl homocitryl molybdenum-heptairon-nonasulphide" EXACT []
xref: RESID:AA0141
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster
is_a: GO:0018291 ! molybdenum incorporation into iron-sulfur cluster
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0018291
name: molybdenum incorporation into iron-sulfur cluster
namespace: biological_process
def: "The incorporation of molybdenum into an iron-sulfur cluster." [GOC:ai]
subset: gosubset_prok
synonym: "molybdenum incorporation into iron-sulphur cluster" EXACT []
is_a: GO:0016226 ! iron-sulfur cluster assembly
is_a: GO:0018289 ! molybdenum incorporation into metallo-sulfur cluster

[Term]
id: GO:0018292
name: molybdenum incorporation via L-cysteinyl molybdopterin
namespace: biological_process
def: "The incorporation of molybdenum into a protein via L-cysteinyl molybdopterin." [RESID:AA0142]
subset: gosubset_prok
xref: RESID:AA0142
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018315 ! molybdenum incorporation into molybdenum-molybdopterin complex

[Term]
id: GO:0018293
name: protein-FAD linkage
namespace: biological_process
def: "The formation of a linkage between a protein amino acid and flavin-adenine dinucleotide (FAD)." [GOC:ai]
subset: gosubset_prok
is_a: GO:0018065 ! protein-cofactor linkage

[Term]
id: GO:0018294
name: protein-FAD linkage via S-(8alpha-FAD)-L-cysteine
namespace: biological_process
def: "The formation of a protein-FAD linkage via S-(8-alpha-FAD)-L-cysteine." [RESID:AA0143]
subset: gosubset_prok
xref: RESID:AA0143
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018293 ! protein-FAD linkage

[Term]
id: GO:0018295
name: protein-FAD linkage via 3'-(8alpha-FAD)-L-histidine
namespace: biological_process
def: "The formation of a protein-FAD linkage via 3'-(8-alpha-FAD)-L-histidine." [RESID:AA0144]
subset: gosubset_prok
xref: RESID:AA0144
is_a: GO:0018202 ! peptidyl-histidine modification
is_a: GO:0018293 ! protein-FAD linkage

[Term]
id: GO:0018296
name: protein-FAD linkage via O4'-(8alpha-FAD)-L-tyrosine
namespace: biological_process
def: "The formation of a protein-FAD linkage via O4'-(8-alpha-FAD)-L-tyrosine." [RESID:AA0145]
subset: gosubset_prok
xref: RESID:AA0145
is_a: GO:0018212 ! peptidyl-tyrosine modification
is_a: GO:0018293 ! protein-FAD linkage

[Term]
id: GO:0018297
name: protein-FAD linkage via 1'-(8alpha-FAD)-L-histidine
namespace: biological_process
def: "The formation of a protein-FAD linkage via 1'-(8-alpha-FAD)-L-histidine." [RESID:AA0221]
subset: gosubset_prok
xref: RESID:AA0221
is_a: GO:0018202 ! peptidyl-histidine modification
is_a: GO:0018293 ! protein-FAD linkage

[Term]
id: GO:0018298
name: protein-chromophore linkage
namespace: biological_process
def: "The covalent or noncovalent attachment of a chromophore to a protein." [GOC:ma]
subset: gosubset_prok
is_a: GO:0006464 ! cellular protein modification process

[Term]
id: GO:0018299
name: iron incorporation into the Rieske iron-sulfur cluster via bis-L-cysteinyl bis-L-histidino diiron disulfide
namespace: biological_process
def: "The incorporation of iron into a Rieske 4Fe-4S iron-sulfur cluster via bis-L-cysteinyl bis-L-histidino diiron disulfide." [RESID:AA0225]
subset: gosubset_prok
synonym: "iron incorporation into the Rieske iron-sulphur cluster via bis-L-cysteinyl bis-L-histidino diiron disulphide" EXACT []
xref: RESID:AA0225
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018202 ! peptidyl-histidine modification
is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0018300
name: obsolete iron incorporation into iron-sulfur cluster via hexakis-L-cysteinyl hexairon hexasulfide
namespace: biological_process
def: "OBSOLETE. The incorporation of iron into a 6Fe-6S cluster by hexakis-L-cysteinyl hexairon hexasulfide." [RESID:AA0226]
comment: This term was made obsolete because the prismane 6Fe-6S cluster is now thought not to exist.
synonym: "iron incorporation into iron-sulfur cluster via hexakis-L-cysteinyl hexairon hexasulfide" EXACT []
synonym: "iron incorporation into iron-sulphur cluster via hexakis-L-cysteinyl hexairon hexasulphide" EXACT []
is_obsolete: true
consider: GO:0018198
consider: GO:0018283

[Term]
id: GO:0018301
name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-cysteine persulfido-bis-L-glutamato-L-histidino tetrairon
namespace: biological_process
def: "The incorporation of iron into an iron-sulfur cluster by tris-L-cysteinyl-L-cysteine persulfido-bis-L-glutamato-L-histidino tetrairon." [RESID:AA0268]
subset: gosubset_prok
synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-cysteine persulphido-bis-L-glutamato-L-histidino tetrairon" EXACT []
xref: RESID:AA0268
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018200 ! peptidyl-glutamic acid modification
is_a: GO:0018202 ! peptidyl-histidine modification
is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0018302
name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-N1'-histidino tetrairon tetrasulfide
namespace: biological_process
def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-N1'-histidino tetrairon tetrasulfide." [RESID:AA0284]
subset: gosubset_prok
synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-N1'-histidino tetrairon tetrasulphide" EXACT []
xref: RESID:AA0284
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018202 ! peptidyl-histidine modification
is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0018303
name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-N3'-histidino tetrairon tetrasulfide
namespace: biological_process
def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-N3'-histidino tetrairon tetrasulfide." [RESID:AA0285]
subset: gosubset_prok
synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-N3'-histidino tetrairon tetrasulphide" EXACT []
xref: RESID:AA0285
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018202 ! peptidyl-histidine modification
is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0018304
name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-aspartato tetrairon tetrasulfide
namespace: biological_process
def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-aspartato tetrairon tetrasulfide." [RESID:AA0286]
subset: gosubset_prok
synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-aspartato tetrairon tetrasulphide" EXACT []
xref: RESID:AA0286
is_a: GO:0018197 ! peptidyl-aspartic acid modification
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0018305
name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-serinyl tetrairon tetrasulfide
namespace: biological_process
def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-serinyl tetrairon tetrasulfide." [RESID:AA0288]
subset: gosubset_prok
synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-serinyl tetrairon tetrasulphide" EXACT []
xref: RESID:AA0288
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018209 ! peptidyl-serine modification
is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0018306
name: iron incorporation into iron-sulfur cluster via bis-L-cysteinyl-L-N3'-histidino-L-serinyl tetrairon tetrasulfide
namespace: biological_process
def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via bis-L-cysteinyl-L-N3'-histidino-L-serinyl tetrairon tetrasulfide." [RESID:AA0289]
subset: gosubset_prok
synonym: "iron incorporation into iron-sulphur cluster via bis-L-cysteinyl-L-N3'-histidino-L-serinyl tetrairon tetrasulphide" EXACT []
xref: RESID:AA0289
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018202 ! peptidyl-histidine modification
is_a: GO:0018209 ! peptidyl-serine modification
is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0018307
name: enzyme active site formation
namespace: biological_process
def: "The modification of part of an enzyme to form the active site." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006464 ! cellular protein modification process

[Term]
id: GO:0018308
name: obsolete enzyme active site formation via N6-pyruvic acid 2-iminyl-L-lysine
namespace: biological_process
def: "OBSOLETE. The transient modification of lysine by pyruvate to form N6-pyruvic acid 2-iminyl-L-lysine, found in the active site of dihydrodipicolinate synthase." [PMID:1463470, RESID:AA0287]
comment: This term was made obsolete because this process does not occur: the modification occurs before it can be an active site.
synonym: "enzyme active site formation via N6-pyruvic acid 2-iminyl-L-lysine" EXACT []
is_obsolete: true

[Term]
id: GO:0018309
name: protein-FMN linkage
namespace: biological_process
def: "The formation of a linkage between a protein amino acid and flavin mononucleotide (FMN)." [GOC:mah]
subset: gosubset_prok
is_a: GO:0018065 ! protein-cofactor linkage

[Term]
id: GO:0018310
name: protein-FMN linkage via S-(6-FMN)-L-cysteine
namespace: biological_process
def: "The formation of a protein-FMN linkage via S-(6-FMN)-L-cysteine." [RESID:AA0220]
subset: gosubset_prok
xref: RESID:AA0220
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018309 ! protein-FMN linkage

[Term]
id: GO:0018311
name: peptidyl-N4-hydroxymethyl-L-asparagine biosynthetic process from peptidyl-asparagine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of N4-hydroxymethyl-L-asparagine from other compounds, including peptidyl-asparagine." [RESID:AA0236]
subset: gosubset_prok
synonym: "peptidyl-N4-hydroxymethyl-L-asparagine anabolism from peptidyl-asparagine" EXACT []
synonym: "peptidyl-N4-hydroxymethyl-L-asparagine formation from peptidyl-asparagine" EXACT []
synonym: "peptidyl-N4-hydroxymethyl-L-asparagine synthesis from peptidyl-asparagine" EXACT []
xref: RESID:AA0236
is_a: GO:0018196 ! peptidyl-asparagine modification

[Term]
id: GO:0018312
name: peptidyl-serine ADP-ribosylation
namespace: biological_process
def: "The transfer, from NAD, of ADP-ribose to peptidyl-serine to form peptidyl-O-(ADP-ribosyl)-L-serine." [RESID:AA0237]
subset: gosubset_prok
xref: RESID:AA0237
is_a: GO:0006471 ! protein ADP-ribosylation
is_a: GO:0018209 ! peptidyl-serine modification

[Term]
id: GO:0018313
name: peptide cross-linking via L-alanyl-5-imidazolinone glycine
namespace: biological_process
def: "The formation of a protein active site cross-link from the alpha-carboxyl carbon of residue N, an alanine, to the alpha-amino nitrogen of residue N+2, a glycine, coupled with the formation of a double bond to the alpha-amino nitrogen of residue N+1 which loses one hydrogen, and the loss of a molecule of water." [RESID:AA0187]
subset: gosubset_prok
xref: RESID:AA0187
is_a: GO:0018194 ! peptidyl-alanine modification
is_a: GO:0018253 ! peptide cross-linking via 5-imidazolinone glycine

[Term]
id: GO:0018314
name: obsolete protein-pyrroloquinoline-quinone linkage
namespace: biological_process
def: "OBSOLETE. The covalent cross-linking of pyrroloquinoline-quinone to peptidyl-glutamic acid and peptidyl-tyrosine." [PMID:7665488, RESID:AA0283]
synonym: "protein-pyrroloquinoline-quinone linkage" EXACT []
is_obsolete: true
replaced_by: GO:0006464

[Term]
id: GO:0018315
name: molybdenum incorporation into molybdenum-molybdopterin complex
namespace: biological_process
alt_id: GO:0042041
def: "The incorporation of molybdenum into a molybdenum-molybdopterin complex." [GOC:ai]
subset: gosubset_prok
synonym: "molybdenum incorporation into metallo-pterin complex" EXACT []
is_a: GO:0042040 ! metal incorporation into metallo-molybdopterin complex
relationship: has_part GO:0061599 ! molybdopterin molybdotransferase activity

[Term]
id: GO:0018316
name: peptide cross-linking via L-cystine
namespace: biological_process
def: "The oxidation of two peptidyl-cysteine residues to form a peptidyl-L-cystine (dicysteine) in which segments of peptide chain are linked by a disulfide bond; the cross-link may be between different or the same peptide chain." [RESID:AA0025]
subset: gosubset_prok
xref: RESID:AA0025
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018317
name: protein C-linked glycosylation via tryptophan
namespace: biological_process
def: "The glycosylation of a carbon atom of a peptidyl-tryptophan residue." [GOC:ai]
subset: gosubset_prok
synonym: "protein amino acid C-linked glycosylation via tryptophan" EXACT [GOC:bf]
is_a: GO:0018103 ! protein C-linked glycosylation
is_a: GO:0018211 ! peptidyl-tryptophan modification

[Term]
id: GO:0018320
name: enzyme active site formation via S-methyl-L-cysteine
namespace: biological_process
def: "The transient methylation of peptidyl-cysteine to form S-methyl-L-cysteine." [RESID:AA0234]
subset: gosubset_prok
xref: RESID:AA0234
is_a: GO:0018125 ! peptidyl-cysteine methylation
is_a: GO:0018307 ! enzyme active site formation

[Term]
id: GO:0018321
name: protein glucuronylation
namespace: biological_process
def: "The modification of a protein by amino acid glucuronylation, the addition of a glucuronate group, the uronic acid derived from glucose." [GOC:ai, GOC:pr]
subset: gosubset_prok
synonym: "protein amino acid glucuronylation" EXACT [GOC:bf]
is_a: GO:0006486 ! protein glycosylation
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:0018322
name: protein tyrosinylation
namespace: biological_process
def: "The addition of a tyrosine molecule to a protein amino acid." [GOC:ai]
subset: gosubset_prok
synonym: "protein amino acid tyrosinylation" EXACT [GOC:bf]
is_a: GO:0006464 ! cellular protein modification process

[Term]
id: GO:0018323
name: enzyme active site formation via L-cysteine sulfinic acid
namespace: biological_process
def: "The oxidation of peptidyl-cysteine to form peptidyl-L-cysteine sulfinic acid." [RESID:AA0262]
subset: gosubset_prok
synonym: "enzyme active site formation via L-cysteine sulphinic acid" EXACT []
xref: RESID:AA0262
is_a: GO:0018171 ! peptidyl-cysteine oxidation
is_a: GO:0018307 ! enzyme active site formation

[Term]
id: GO:0018324
name: enzyme active site formation via L-cysteine sulfenic acid
namespace: biological_process
def: "The oxidation of peptidyl-cysteine to form peptidyl-L-cysteine sulfenic acid, found in the active site of NADH peroxidase, nitrile hydratase, and peptide methionine sulfoxide reductase." [PMID:2501303, RESID:AA0205]
subset: gosubset_prok
synonym: "enzyme active site formation via L-cysteine sulphenic acid" EXACT []
xref: RESID:AA0205
is_a: GO:0018171 ! peptidyl-cysteine oxidation
is_a: GO:0018307 ! enzyme active site formation

[Term]
id: GO:0018325
name: enzyme active site formation via S-phospho-L-cysteine
namespace: biological_process
def: "The transient phosphorylation of peptidyl-cysteine to form S-phospho-L-cysteine." [RESID:AA0034]
subset: gosubset_prok
xref: RESID:AA0034
is_a: GO:0018218 ! peptidyl-cysteine phosphorylation
is_a: GO:0018307 ! enzyme active site formation

[Term]
id: GO:0018326
name: enzyme active site formation via S-acetyl-L-cysteine
namespace: biological_process
def: "The transient acetylation of peptidyl-cysteine to form S-acetyl-L-cysteine." [RESID:AA0056]
subset: gosubset_prok
xref: RESID:AA0056
is_a: GO:0018219 ! peptidyl-cysteine S-acetylation
is_a: GO:0018307 ! enzyme active site formation

[Term]
id: GO:0018327
name: enzyme active site formation via 1'-phospho-L-histidine
namespace: biological_process
def: "The transient phosphorylation of peptidyl-histidine to form 1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine)." [RESID:AA0035]
subset: gosubset_prok
xref: RESID:AA0035
is_a: GO:0018106 ! peptidyl-histidine phosphorylation
is_a: GO:0018307 ! enzyme active site formation

[Term]
id: GO:0018328
name: enzyme active site formation via 3'-phospho-L-histidine
namespace: biological_process
def: "The transient phosphorylation of peptidyl-histidine to form 3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine)." [RESID:AA0036]
subset: gosubset_prok
xref: RESID:AA0036
is_a: GO:0018106 ! peptidyl-histidine phosphorylation
is_a: GO:0018307 ! enzyme active site formation

[Term]
id: GO:0018329
name: enzyme active site formation via N6-(phospho-5'-adenosine)-L-lysine
namespace: biological_process
def: "The transient adenylylation of lysine to form N6-(phospho-5'-adenosine)-L-lysine, found in the active site of DNA ligase and RNA ligase." [RESID:AA0227]
subset: gosubset_prok
xref: RESID:AA0227
is_a: GO:0018116 ! peptidyl-lysine adenylylation
is_a: GO:0018307 ! enzyme active site formation

[Term]
id: GO:0018330
name: enzyme active site formation via N6-(phospho-5'-guanosine)-L-lysine
namespace: biological_process
def: "The transient guanylylation of lysine to form N6-(phospho-5'-guanosine)-L-lysine, found in the guanylyltransferase active site of mRNA capping enzyme." [RESID:AA0228]
subset: gosubset_prok
xref: RESID:AA0228
is_a: GO:0018261 ! peptidyl-lysine guanylylation
is_a: GO:0018307 ! enzyme active site formation

[Term]
id: GO:0018331
name: enzyme active site formation via O-phospho-L-serine
namespace: biological_process
def: "The transient phosphorylation of peptidyl-serine to form O-phospho-L-serine." [RESID:AA0037]
subset: gosubset_prok
xref: RESID:AA0037
is_a: GO:0018105 ! peptidyl-serine phosphorylation
is_a: GO:0018307 ! enzyme active site formation

[Term]
id: GO:0018332
name: enzyme active site formation via O-(phospho-5'-adenosine)-L-threonine
namespace: biological_process
def: "The transient adenylylation of threonine to form N6-(phospho-5'-adenosine)-L-threonine, found in the active site of bovine phosphodiesterase I." [RESID:AA0267]
subset: gosubset_prok
xref: RESID:AA0267
is_a: GO:0018178 ! peptidyl-threonine adenylylation
is_a: GO:0018307 ! enzyme active site formation

[Term]
id: GO:0018333
name: enzyme active site formation via O-phospho-L-threonine
namespace: biological_process
def: "The transient phosphorylation of peptidyl-threonine to form O-phospho-L-threonine." [RESID:AA0038]
subset: gosubset_prok
xref: RESID:AA0038
is_a: GO:0018107 ! peptidyl-threonine phosphorylation
is_a: GO:0018307 ! enzyme active site formation

[Term]
id: GO:0018334
name: enzyme active site formation via O4'-phospho-L-tyrosine
namespace: biological_process
def: "The transient phosphorylation of peptidyl-tyrosine to form O-phospho-L-tyrosine." [RESID:AA0039]
subset: gosubset_prok
xref: RESID:AA0039
is_a: GO:0018108 ! peptidyl-tyrosine phosphorylation
is_a: GO:0018307 ! enzyme active site formation

[Term]
id: GO:0018335
name: protein succinylation
namespace: biological_process
def: "The modification of a protein by the addition of a succinyl group (CO-CH2-CH2-CO) to an amino acid residue." [CHEBI:37952, GOC:bf]
subset: gosubset_prok
synonym: "protein amino acid succinylation" EXACT [GOC:bf]
is_a: GO:0043543 ! protein acylation

[Term]
id: GO:0018336
name: peptidyl-tyrosine hydroxylation
namespace: biological_process
def: "The hydroxylation of peptidyl-tyrosine to form peptidyl-dihydroxyphenylalanine." [GOC:ai]
subset: gosubset_prok
is_a: GO:0018126 ! protein hydroxylation

[Term]
id: GO:0018337
name: obsolete enzyme active site formation via L-2',4',5'-topaquinone
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because this process does not occur: the modification occurs before it can be an active site.
synonym: "enzyme active site formation via L-2',4',5'-topaquinone" EXACT []
is_obsolete: true

[Term]
id: GO:0018338
name: obsolete protein amino acid cinnamylation
namespace: biological_process
def: "OBSOLETE. The modification of a protein amino acid by cinnamylation." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "protein amino acid cinnamylation" EXACT []
is_obsolete: true
consider: GO:0018097

[Term]
id: GO:0018339
name: peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid
namespace: biological_process
def: "The modification of peptidyl-aspartic acid to form peptidyl-L-beta-methylthioaspartic acid, typical of bacterial ribosomal protein S12." [RESID:AA0232]
subset: gosubset_prok
synonym: "peptidyl-aspartic acid methylthiolation" EXACT []
synonym: "peptidyl-L-beta-methylthioaspartic acid anabolism from peptidyl-aspartic acid" EXACT []
synonym: "peptidyl-L-beta-methylthioaspartic acid formation from peptidyl-aspartic acid" EXACT []
synonym: "peptidyl-L-beta-methylthioaspartic acid synthesis from peptidyl-aspartic acid" EXACT []
xref: RESID:AA0232
is_a: GO:0018197 ! peptidyl-aspartic acid modification
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018340
name: peptidyl-O-(sn-1-glycerophosphoryl)-L-serine biosynthetic process from peptidyl-serine
namespace: biological_process
def: "The modification of peptidyl-serine to peptidyl-O-(sn-1-glycerophosphoryl)-L-serine." [RESID:AA0264]
subset: gosubset_prok
synonym: "peptidyl-O-(sn-1-glycerophosphoryl)-L-serine anabolism from peptidyl-serine" EXACT []
synonym: "peptidyl-O-(sn-1-glycerophosphoryl)-L-serine formation from peptidyl-serine" EXACT []
synonym: "peptidyl-O-(sn-1-glycerophosphoryl)-L-serine synthesis from peptidyl-serine" EXACT []
xref: RESID:AA0264
is_a: GO:0018209 ! peptidyl-serine modification

[Term]
id: GO:0018341
name: peptidyl-lysine modification to peptidyl-N6-pyruvic acid 2-iminyl-L-lysine
namespace: biological_process
def: "The modification of peptidyl-lysine to form peptidyl-N6-pyruvic acid 2-iminyl-L-lysine." [PSI-MOD:00292]
subset: gosubset_prok
synonym: "peptidyl-N6-pyruvic acid 2-iminyl-L-lysine anabolism" EXACT []
synonym: "peptidyl-N6-pyruvic acid 2-iminyl-L-lysine biosynthesis" EXACT []
synonym: "peptidyl-N6-pyruvic acid 2-iminyl-L-lysine biosynthetic process" EXACT []
synonym: "peptidyl-N6-pyruvic acid 2-iminyl-L-lysine formation" EXACT []
synonym: "peptidyl-N6-pyruvic acid 2-iminyl-L-lysine synthesis" EXACT []
is_a: GO:0018205 ! peptidyl-lysine modification

[Term]
id: GO:0018342
name: protein prenylation
namespace: biological_process
alt_id: GO:0018346
def: "The covalent attachment of a prenyl group to a protein; geranyl, farnesyl, or geranylgeranyl groups may be added." [GOC:di, ISBN:0198506732]
subset: gosubset_prok
synonym: "C-terminal protein prenylation" NARROW []
synonym: "protein amino acid prenylation" EXACT [GOC:bf]
is_a: GO:0006464 ! cellular protein modification process
is_a: GO:0097354 ! prenylation

[Term]
id: GO:0018343
name: protein farnesylation
namespace: biological_process
alt_id: GO:0018347
def: "The covalent attachment of a farnesyl group to a protein." [GOC:jl]
subset: gosubset_prok
synonym: "C-terminal protein farnesylation" NARROW []
synonym: "protein amino acid farnesylation" EXACT [GOC:bf]
is_a: GO:0018342 ! protein prenylation

[Term]
id: GO:0018344
name: protein geranylgeranylation
namespace: biological_process
alt_id: GO:0018348
def: "The covalent attachment of a geranylgeranyl group to a protein." [GOC:jl]
subset: gosubset_prok
synonym: "C-terminal protein geranylgeranylation" NARROW []
synonym: "protein amino acid geranylgeranylation" EXACT [GOC:bf]
is_a: GO:0018342 ! protein prenylation

[Term]
id: GO:0018345
name: protein palmitoylation
namespace: biological_process
alt_id: GO:0018318
alt_id: GO:0018349
def: "The covalent attachment of a palmitoyl group to a protein." [GOC:jl, PMID:15520806]
subset: gosubset_prok
synonym: "protein amino acid palmitoylation" EXACT [GOC:bf]
is_a: GO:0006497 ! protein lipidation
is_a: GO:0043543 ! protein acylation

[Term]
id: GO:0018350
name: protein esterification
namespace: biological_process
def: "The addition of an ester group to a protein amino acid." [GOC:ai]
subset: gosubset_prok
synonym: "protein amino acid esterification" EXACT [GOC:bf]
is_a: GO:0006464 ! cellular protein modification process

[Term]
id: GO:0018351
name: peptidyl-cysteine esterification
namespace: biological_process
def: "The addition of an ester group to a cysteine residue in a protein." [GOC:mah]
subset: gosubset_prok
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018350 ! protein esterification

[Term]
id: GO:0018352
name: protein-pyridoxal-5-phosphate linkage
namespace: biological_process
def: "The formation of a linkage between a protein amino acid and pyridoxal-5-phosphate." [GOC:mah]
subset: gosubset_prok
is_a: GO:0018065 ! protein-cofactor linkage

[Term]
id: GO:0018353
name: protein-phycocyanobilin linkage via S-phycocyanobilin-L-cysteine
namespace: biological_process
alt_id: GO:0018380
def: "The linkage of the chromophore phycocyanobilin to phycocyanin or allophycocyanin via S-phycocyanobilin-L-cysteine." [RESID:AA0131]
subset: gosubset_prok
xref: RESID:AA0131
is_a: GO:0017009 ! protein-phycocyanobilin linkage
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018355
name: protein-phosphoribosyl dephospho-coenzyme A linkage via O-(phosphoribosyl dephospho-coenzyme A)-L-serine
namespace: biological_process
def: "The formation of a protein-phosphoribosyl dephospho-coenzyme A linkage via O-(phosphoribosyl dephospho-coenzyme A)-L-serine." [RESID:AA00167]
subset: gosubset_prok
is_a: GO:0018247 ! protein-phosphoribosyl dephospho-coenzyme A linkage

[Term]
id: GO:0018356
name: protein-phycobiliviolin linkage via S-phycobiliviolin-L-cysteine
namespace: biological_process
alt_id: GO:0018382
def: "The linkage of the chromophore phycobiliviolin to phycoerythrocyanin via S-phycobiliviolin-L-cysteine." [RESID:AA0258]
subset: gosubset_prok
xref: RESID:AA0258
is_a: GO:0017008 ! protein-phycobiliviolin linkage

[Term]
id: GO:0018357
name: protein-phycourobilin linkage via phycourobilin-bis-L-cysteine
namespace: biological_process
alt_id: GO:0018383
def: "The linkage of the chromophore phycourobilin to phycoerythrins via phycourobilin-bis-L-cysteine." [RESID:AA0260]
subset: gosubset_prok
xref: RESID:AA0260
is_a: GO:0017010 ! protein-phycourobilin linkage
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018358
name: protein-phytochromobilin linkage via S-phytochromobilin-L-cysteine
namespace: biological_process
alt_id: GO:0018381
def: "The linkage of the chromophore phytochromobilin to phycocyanin or allophycocyanin via S-phytochromobilin-L-cysteine." [RESID:AA0133]
subset: gosubset_prok
xref: RESID:AA0133
is_a: GO:0017012 ! protein-phytochromobilin linkage
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018359
name: protein-heme P460 linkage via heme P460-bis-L-cysteine-L-tyrosine
namespace: biological_process
alt_id: GO:0018385
def: "The linkage of protein to heme P460 via heme P460-bis-L-cysteine-L-tyrosine." [RESID:AA0266]
subset: gosubset_prok
synonym: "protein-haem P460 linkage via haem P460-bis-L-cysteine-L-tyrosine" EXACT []
xref: RESID:AA0266
is_a: GO:0018174 ! protein-heme P460 linkage
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018212 ! peptidyl-tyrosine modification

[Term]
id: GO:0018360
name: protein-heme P460 linkage via heme P460-bis-L-cysteine-L-lysine
namespace: biological_process
alt_id: GO:0018384
def: "The linkage of protein to heme P460 via heme P460-bis-L-cysteine-L-lysine." [RESID:AA0271]
subset: gosubset_prok
synonym: "protein-haem P460 linkage via haem P460-bis-L-cysteine-L-lysine" EXACT []
xref: RESID:AA0271
is_a: GO:0018174 ! protein-heme P460 linkage
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018205 ! peptidyl-lysine modification

[Term]
id: GO:0018361
name: peptidyl-glutamine 2-methylation
namespace: biological_process
def: "The methylation of glutamine to form 2-methyl-L-glutamine." [http://www.uni-marburg.de/mpi/thauer/thauer_res.html, RESID:AA0273]
subset: gosubset_prok
xref: RESID:AA0273
is_a: GO:0018364 ! peptidyl-glutamine methylation

[Term]
id: GO:0018362
name: peroxidase-heme linkage via dihydroxyheme-L-aspartyl ester-L-glutamyl ester
namespace: biological_process
alt_id: GO:0019924
def: "The covalent linkage of heme to peroxidase via dihydroxyheme-L-aspartyl ester-L-glutamyl ester." [RESID:AA0279]
subset: gosubset_prok
synonym: "peroxidase-haem linkage via dihydroxyhaem-L-aspartyl ester-L-glutamyl ester" EXACT []
xref: RESID:AA0279
is_a: GO:0018186 ! peroxidase-heme linkage
is_a: GO:0018200 ! peptidyl-glutamic acid modification

[Term]
id: GO:0018363
name: peroxidase-heme linkage via dihydroxyheme-L-aspartyl ester-L-glutamyl ester-L-methionine sulfonium
namespace: biological_process
alt_id: GO:0019925
def: "The covalent linkage of heme to peroxidase via dihydroxyheme-L-aspartyl ester-L-glutamyl ester-L-methionine sulfonium." [RESID:AA0280]
subset: gosubset_prok
synonym: "peroxidase-haem linkage via dihydroxyhaem-L-aspartyl ester-L-glutamyl ester-L-methionine sulfonium" EXACT []
synonym: "peroxidase-heme linkage via dihydroxyheme-L-aspartyl ester-L-glutamyl ester-L-methionine sulphonium" EXACT []
xref: RESID:AA0280
is_a: GO:0018186 ! peroxidase-heme linkage
is_a: GO:0018200 ! peptidyl-glutamic acid modification
is_a: GO:0018206 ! peptidyl-methionine modification

[Term]
id: GO:0018364
name: peptidyl-glutamine methylation
namespace: biological_process
def: "The addition of a methyl group to a glutamine residue in a protein." [GOC:mah]
subset: gosubset_prok
is_a: GO:0006479 ! protein methylation

[Term]
id: GO:0018365
name: protein-serine epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: (protein)-L-serine = (protein)-D-serine." [EC:5.1.1.16]
synonym: "protein-serine racemase activity" EXACT [EC:5.1.1.16]
xref: EC:5.1.1.16
xref: MetaCyc:5.1.1.16-RXN
is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives

[Term]
id: GO:0018366
name: chiral amino acid racemization
namespace: biological_process
def: "The formation of a mixture of the two possible enantiomers from the D- or L-enantiomer of a chiral amino acid." [GOC:jsg, ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0006520 ! cellular amino acid metabolic process

[Term]
id: GO:0018367
name: obsolete free L-amino acid racemization
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it is not clear that this process occurs.
synonym: "free L-amino acid racemization" EXACT []
is_obsolete: true
consider: GO:0006520

[Term]
id: GO:0018376
name: peptidyl-asparagine hydroxylation to form L-erythro-beta-hydroxyasparagine
namespace: biological_process
def: "The hydroxylation of peptidyl-asparagine to form peptidyl-L-erythro-beta-hydroxyasparagine; catalyzed by peptide-aspartate beta-dioxygenase (EC:1.14.11.16)." [RESID:AA0026]
comment: See also the molecular function term 'peptide-aspartate beta-dioxygenase activity ; GO:0004597'.
subset: gosubset_prok
xref: RESID:AA0026
is_a: GO:0042265 ! peptidyl-asparagine hydroxylation

[Term]
id: GO:0018377
name: protein myristoylation
namespace: biological_process
alt_id: GO:0018319
def: "The covalent attachment of a myristoyl group to a protein." [GOC:ai]
subset: gosubset_prok
synonym: "protein amino acid myristoylation" EXACT [GOC:bf]
is_a: GO:0006497 ! protein lipidation
is_a: GO:0043543 ! protein acylation

[Term]
id: GO:0018378
name: cytochrome c-heme linkage via heme-L-cysteine
namespace: biological_process
def: "The linkage of cytochromes and other heme proteins to heme via heme-L-cysteine." [RESID:AA0135]
subset: gosubset_prok
synonym: "cytochrome c-haem linkage via haem-L-cysteine" EXACT []
xref: RESID:AA0135
is_a: GO:0018063 ! cytochrome c-heme linkage
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018379
name: cytochrome c-heme linkage via heme-bis-L-cysteine
namespace: biological_process
def: "The linkage of cytochromes and other heme proteins to heme via heme-bis-L-cysteine." [RESID:AA0134]
subset: gosubset_prok
synonym: "cytochrome c-haem linkage via haem-bis-L-cysteine" EXACT []
xref: RESID:AA0134
is_a: GO:0018063 ! cytochrome c-heme linkage
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018386
name: N-terminal peptidyl-cysteine condensation with pyruvate to form N-pyruvic acid 2-iminyl-L-cysteine
namespace: biological_process
def: "The condensation of pyruvate through the 2-oxo group with the N-terminal cysteine of proteins to form the derivative N-pyruvic acid 2-iminyl-L-cysteine." [RESID:AA0274]
subset: gosubset_prok
xref: RESID:AA0274
is_a: GO:0031365 ! N-terminal protein amino acid modification

[Term]
id: GO:0018387
name: N-terminal peptidyl-amino acid deamination to pyruvic acid
namespace: biological_process
def: "The oxidative deamination of N-terminal peptidyl-cysteine, or peptidyl-serine, to form pyruvic acid with an amide bond between its 1-carboxyl group and the N-terminal residue." [RESID:AA0127]
subset: gosubset_prok
xref: RESID:AA0127
is_a: GO:0018058 ! N-terminal protein amino acid deamination, from amino carbon

[Term]
id: GO:0018388
name: N-terminal peptidyl-valine condensation with pyruvate to form N-pyruvic acid 2-iminyl-L-valine
namespace: biological_process
def: "The condensation of pyruvate through the 2-oxo group with the N-terminal valine of proteins to form the derivative N-pyruvic acid 2-iminyl-L-valine." [RESID:AA0275]
subset: gosubset_prok
xref: RESID:AA0275
is_a: GO:0018213 ! peptidyl-valine modification
is_a: GO:0031365 ! N-terminal protein amino acid modification

[Term]
id: GO:0018389
name: N-terminal peptidyl-valine deamination
namespace: biological_process
def: "The deamination of the N-terminal valine residue of a protein to form isobutyrate." [GOC:ma, GOC:mah]
subset: gosubset_prok
is_a: GO:0018058 ! N-terminal protein amino acid deamination, from amino carbon

[Term]
id: GO:0018390
name: peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from peptidyl-glutamic acid or peptidyl-glutamine
namespace: biological_process
def: "The methyl esterification of peptidyl-glutamic acid or peptidyl-glutamine to form the derivative glutamic acid 5-methyl ester." [RESID:AA0072]
subset: gosubset_prok
synonym: "peptidyl-L-glutamic acid 5-methyl ester anabolism from peptidyl-glutamic acid or peptidyl-glutamine" EXACT []
synonym: "peptidyl-L-glutamic acid 5-methyl ester formation from peptidyl-glutamic acid or peptidyl-glutamine" EXACT []
synonym: "peptidyl-L-glutamic acid 5-methyl ester synthesis from peptidyl-glutamic acid or peptidyl-glutamine" EXACT []
xref: RESID:AA0072
is_a: GO:0018199 ! peptidyl-glutamine modification
is_a: GO:0018442 ! peptidyl-glutamic acid esterification

[Term]
id: GO:0018391
name: C-terminal peptidyl-glutamic acid tyrosinylation
namespace: biological_process
def: "The ATP-dependent addition of a tyrosine residue to a glutamic acid residue at the C-terminus of a protein." [GOC:mah]
subset: gosubset_prok
is_a: GO:0018166 ! C-terminal protein-tyrosinylation
is_a: GO:0018200 ! peptidyl-glutamic acid modification

[Term]
id: GO:0018392
name: glycoprotein 3-alpha-L-fucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP-L-fucose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP + H(+)." [EC:2.4.1.214, RHEA:24447]
synonym: "GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fuc-alpha-1->6-GlcNAc)-Asn-peptide) alpha-1->3-fucosyltransferase activity" EXACT [EC:2.4.1.214]
synonym: "GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fucalpha1->6-GlcNAc)-Asn-peptide) alpha1->3-fucosyltransferase activity" EXACT [EC:2.4.1.214]
synonym: "GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fucalpha1->6GlcNAc)-Asn-peptide) alpha1->3-fucosyltransferase activity" EXACT [EC:2.4.1.214]
synonym: "GDP-L-Fuc:Asn-linked GlcNAc alpha-1,3-fucosyltransferase activity" EXACT [EC:2.4.1.214]
synonym: "GDP-L-Fuc:Asn-linked GlcNAc alpha1,3-fucosyltransferase activity" EXACT [EC:2.4.1.214]
synonym: "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha-1,3-fucosyltransferase activity" EXACT [EC:2.4.1.214]
synonym: "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,3-fucosyltransferase activity" EXACT [EC:2.4.1.214]
synonym: "GDP-L-fucose:asparagine-linked N-acetylglucosamine alpha(1,3)-fucosyltransferase activity" EXACT []
synonym: "GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of 4-N-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 3-alpha-L-fucosyl-transferase activity" EXACT [EC:2.4.1.214]
synonym: "GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 3-alpha-L-fucosyl-transferase activity" EXACT [EC:2.4.1.214]
xref: EC:2.4.1.214
xref: KEGG:R06015
xref: MetaCyc:2.4.1.214-RXN
xref: RHEA:24447
is_a: GO:0046920 ! alpha-(1->3)-fucosyltransferase activity

[Term]
id: GO:0018393
name: internal peptidyl-lysine acetylation
namespace: biological_process
def: "The addition of an acetyl group to a non-terminal lysine residue in a protein." [GOC:mah]
subset: gosubset_prok
is_a: GO:0006475 ! internal protein amino acid acetylation
is_a: GO:0018394 ! peptidyl-lysine acetylation

[Term]
id: GO:0018394
name: peptidyl-lysine acetylation
namespace: biological_process
def: "The acetylation of peptidyl-lysine." [GOC:mah]
subset: gosubset_prok
is_a: GO:0006473 ! protein acetylation
is_a: GO:0018205 ! peptidyl-lysine modification

[Term]
id: GO:0018395
name: peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine
namespace: biological_process
def: "The hydroxylation of peptidyl-lysine to peptidyl-5-hydroxy-L-lysine." [RESID:AA0028]
subset: gosubset_prok
xref: RESID:AA0028
is_a: GO:0017185 ! peptidyl-lysine hydroxylation

[Term]
id: GO:0018396
name: peptidyl-lysine hydroxylation to 4-hydroxy-L-lysine
namespace: biological_process
def: "The hydroxylation of peptidyl-lysine to peptidyl-4-hydroxy-L-lysine." [RESID:AA0235]
subset: gosubset_prok
xref: RESID:AA0235
is_a: GO:0006575 ! cellular modified amino acid metabolic process
is_a: GO:0017185 ! peptidyl-lysine hydroxylation
is_a: GO:1901605 ! alpha-amino acid metabolic process

[Term]
id: GO:0018397
name: peptidyl-phenylalanine bromination to L-2'-bromophenylalanine
namespace: biological_process
def: "The bromination of peptidyl-phenylalanine to form L-2'-bromophenylalanine." [RESID:AA0174]
subset: gosubset_prok
xref: RESID:AA0174
is_a: GO:0006520 ! cellular amino acid metabolic process
is_a: GO:0006575 ! cellular modified amino acid metabolic process
is_a: GO:0018075 ! peptidyl-phenylalanine bromination

[Term]
id: GO:0018398
name: peptidyl-phenylalanine bromination to L-3'-bromophenylalanine
namespace: biological_process
def: "The bromination of peptidyl-phenylalanine to form L-3'-bromophenylalanine." [RESID:AA0175]
subset: gosubset_prok
xref: RESID:AA0175
is_a: GO:0006520 ! cellular amino acid metabolic process
is_a: GO:0006575 ! cellular modified amino acid metabolic process
is_a: GO:0018075 ! peptidyl-phenylalanine bromination

[Term]
id: GO:0018399
name: peptidyl-phenylalanine bromination to L-4'-bromophenylalanine
namespace: biological_process
def: "The bromination of peptidyl-phenylalanine to form L-4'-bromophenylalanine." [RESID:AA0176]
subset: gosubset_prok
xref: RESID:AA0176
is_a: GO:0006520 ! cellular amino acid metabolic process
is_a: GO:0006575 ! cellular modified amino acid metabolic process
is_a: GO:0018075 ! peptidyl-phenylalanine bromination

[Term]
id: GO:0018400
name: peptidyl-proline hydroxylation to 3-hydroxy-L-proline
namespace: biological_process
def: "The modification of peptidyl-proline to form 3-hydroxy-L-proline; catalyzed by procollagen-proline 3-dioxygenase." [RESID:AA0029]
comment: See also the molecular function term 'procollagen-proline 3-dioxygenase activity ; GO:0019797'.
subset: gosubset_prok
xref: RESID:AA0029
is_a: GO:0006575 ! cellular modified amino acid metabolic process
is_a: GO:0019511 ! peptidyl-proline hydroxylation
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901605 ! alpha-amino acid metabolic process

[Term]
id: GO:0018401
name: peptidyl-proline hydroxylation to 4-hydroxy-L-proline
namespace: biological_process
def: "The modification of peptidyl-proline to form 4-hydroxy-L-proline; catalyzed by procollagen-proline,2-oxoglutarate-4-dioxygenase." [RESID:AA0030]
comment: See also the molecular function term 'procollagen-proline 4-dioxygenase activity ; GO:0004656'.
subset: gosubset_prok
xref: RESID:AA0030
is_a: GO:0019471 ! 4-hydroxyproline metabolic process
is_a: GO:0019511 ! peptidyl-proline hydroxylation

[Term]
id: GO:0018402
name: protein-chondroitin sulfate linkage via chondroitin sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine
namespace: biological_process
def: "Chondroitin sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and serine residues." [RESID:AA0208]
subset: gosubset_prok
synonym: "protein-chondroitin sulphate linkage via chondroitin sulphate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine" EXACT []
xref: RESID:AA0208
is_a: GO:0018209 ! peptidyl-serine modification
is_a: GO:0030204 ! chondroitin sulfate metabolic process

[Term]
id: GO:0018403
name: protein-dermatan sulfate linkage via dermatan 4-sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine
namespace: biological_process
def: "Dermatan sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and serine residues." [PMID:7338506, RESID:AA0209]
subset: gosubset_prok
synonym: "protein-dermatan sulphate linkage via dermatan 4-sulphate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine" EXACT []
xref: RESID:AA0209
is_a: GO:0018209 ! peptidyl-serine modification

[Term]
id: GO:0018404
name: protein-heparan sulfate linkage via heparan sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine
namespace: biological_process
def: "Heparan sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and serine residues." [RESID:AA0210]
subset: gosubset_prok
synonym: "protein-heparan sulphate linkage via heparan sulphate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine" EXACT []
xref: RESID:AA0210
is_a: GO:0018209 ! peptidyl-serine modification

[Term]
id: GO:0018405
name: protein-keratan sulfate linkage via keratan sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-threonine
namespace: biological_process
def: "Keratan sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and threonine residues." [RESID:AA0247]
subset: gosubset_prok
synonym: "protein-keratan sulphate linkage via keratan sulphate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-threonine" EXACT []
xref: RESID:AA0247
is_a: GO:0018210 ! peptidyl-threonine modification

[Term]
id: GO:0018406
name: protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan
namespace: biological_process
alt_id: GO:0032004
def: "The glycosylation of a peptidyl-tryptophan residue by the transfer of alpha-mannopyranose from dolichyl-activated mannose to the indole ring." [PMID:7947762, PMID:9450955, RESID:AA0217]
synonym: "protein amino acid C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan" EXACT [GOC:bf]
synonym: "protein amino acid C-linked mannosylation" EXACT []
xref: RESID:AA0217
is_a: GO:0018317 ! protein C-linked glycosylation via tryptophan
is_a: GO:0035268 ! protein mannosylation

[Term]
id: GO:0018407
name: peptidyl-thyronine iodination to form 3',3'',5'-triiodo-L-thyronine
namespace: biological_process
def: "The iodination of peptidyl-thyronine to form peptidyl-3',3'',5'-triiodo-L-thyronine (triiodothyronine)." [RESID:AA0177]
subset: gosubset_prok
synonym: "peptidyl-thyronine iodination to form triiodothyronine" BROAD []
xref: RESID:AA0177
is_a: GO:0018078 ! peptidyl-thyronine iodination

[Term]
id: GO:0018408
name: peptidyl-thyronine iodination to form 3',3'',5',5''-tetraiodo-L-thyronine
namespace: biological_process
def: "The iodination of peptidyl-thyronine to form peptidyl-3',3'',5',5''-tetraiodo-L-thyronine (L-thyroxine)." [RESID:AA0178]
subset: gosubset_prok
xref: RESID:AA0178
is_a: GO:0018078 ! peptidyl-thyronine iodination

[Term]
id: GO:0018410
name: C-terminal protein amino acid modification
namespace: biological_process
def: "The alteration of the C-terminal amino acid residue in a protein." [GOC:mah]
subset: gosubset_prok
synonym: "peptide or protein carboxyl-terminal blocking" RELATED []
synonym: "peptide/protein carboxyl-terminal blocking" RELATED []
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0018411
name: protein glucuronidation
namespace: biological_process
def: "The modification of a protein by amino acid glucuronidation." [GOC:ai]
subset: gosubset_prok
synonym: "protein amino acid glucuronidation" EXACT [GOC:bf]
is_a: GO:0006464 ! cellular protein modification process

[Term]
id: GO:0018412
name: protein O-glucuronidation
namespace: biological_process
def: "The modification of a protein by glucuronidation on an amino acid oxygen atom." [GOC:mah]
subset: gosubset_prok
synonym: "protein amino acid O-glucuronidation" EXACT [GOC:bf]
is_a: GO:0018411 ! protein glucuronidation

[Term]
id: GO:0018413
name: peptidyl-serine O-glucuronidation
namespace: biological_process
def: "The O-glucuronidation of peptidyl-serine to form peptidyl-O3-D-glucuronyl-L-serine." [RESID:AA0291]
subset: gosubset_prok
xref: RESID:AA0291
is_a: GO:0018209 ! peptidyl-serine modification
is_a: GO:0018412 ! protein O-glucuronidation

[Term]
id: GO:0018414
name: nickel incorporation into metallo-sulfur cluster
namespace: biological_process
def: "The incorporation of nickel into a metallo-sulfur cluster." [GOC:ai]
subset: gosubset_prok
synonym: "nickel incorporation into metallo-sulphur cluster" EXACT []
is_a: GO:0018282 ! metal incorporation into metallo-sulfur cluster

[Term]
id: GO:0018415
name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide
namespace: biological_process
def: "The incorporation of iron into a 3Fe-2S cluster via tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide." [RESID:AA0292]
subset: gosubset_prok
synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl L-cysteine persulphido bis-L-glutamato L-histidino nickel triiron disulphide trioxide" EXACT []
xref: RESID:AA0292
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018200 ! peptidyl-glutamic acid modification
is_a: GO:0018202 ! peptidyl-histidine modification
is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0018416
name: nickel incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide
namespace: biological_process
def: "The incorporation of nickel into a 3Fe-2S complex by tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide." [RESID:AA0292]
subset: gosubset_prok
synonym: "nickel incorporation into iron-sulphur cluster via tris-L-cysteinyl L-cysteine persulphido bis-L-glutamato L-histidino nickel triiron disulphide trioxide" EXACT []
xref: RESID:AA0292
is_a: GO:0016226 ! iron-sulfur cluster assembly
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018200 ! peptidyl-glutamic acid modification
is_a: GO:0018202 ! peptidyl-histidine modification
is_a: GO:0018414 ! nickel incorporation into metallo-sulfur cluster
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0018417
name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide
namespace: biological_process
def: "The incorporation of iron into a 3Fe-2S cluster by tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide." [RESID:AA0293]
subset: gosubset_prok
synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl L-cysteine persulphido L-glutamato L-histidino L-serinyl nickel triiron disulphide trioxide" EXACT []
xref: RESID:AA0293
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018200 ! peptidyl-glutamic acid modification
is_a: GO:0018202 ! peptidyl-histidine modification
is_a: GO:0018209 ! peptidyl-serine modification
is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0018418
name: nickel incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide
namespace: biological_process
def: "The incorporation of nickel into a 3Fe-2S complex by tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide." [RESID:AA0293]
subset: gosubset_prok
synonym: "nickel incorporation into iron-sulphur cluster via tris-L-cysteinyl L-cysteine persulphido L-glutamato L-histidino L-serinyl nickel triiron disulphide trioxide" EXACT []
xref: RESID:AA0
is_a: GO:0016226 ! iron-sulfur cluster assembly
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018200 ! peptidyl-glutamic acid modification
is_a: GO:0018202 ! peptidyl-histidine modification
is_a: GO:0018414 ! nickel incorporation into metallo-sulfur cluster
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0018419
name: protein catenane formation
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a protein structure comprising two or more rings that are interlocked but not covalently joined; resembling the links of a chain." [ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0043623 ! cellular protein complex assembly

[Term]
id: GO:0018420
name: peptide cross-linking via N6-(L-isoaspartyl)-L-lysine
namespace: biological_process
def: "The formation of isopeptide bonds by ligation of peptidyl-lysine and peptidyl-asparagine residues." [RESID:AA0294]
subset: gosubset_prok
xref: RESID:AA0294
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018196 ! peptidyl-asparagine modification
is_a: GO:0018205 ! peptidyl-lysine modification

[Term]
id: GO:0018421
name: UDP-N-acetylglucosamine:serine-protein N-acetylglucosamine-1-phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of N-acetylglucosamine-1-phosphate to a serine residue in a protein." [GOC:mah, PMID:9353330]
xref: EC:2.7.8.-
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0018422
name: GDP-mannose:serine-protein mannose-1-phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of mannose-1-phosphate to a serine residue in a protein." [GOC:mah, PMID:10037765]
xref: EC:2.7.8.-
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0018423
name: protein C-terminal leucine carboxyl O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + protein L-leucine = S-adenosyl-L-homocysteine + protein L-leucine methyl ester. This modification occurs only at the oxygen atoms of the free alpha carboxyl group of a leucine residue at the C-terminus of the protein." [PMID:8514774]
synonym: "protein phosphatase methyltransferase activity" NARROW []
synonym: "protein-leucine O-methyltransferase activity" EXACT []
xref: EC:2.1.1.-
is_a: GO:0003880 ! protein C-terminal carboxyl O-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0018424
name: peptidyl-glutamic acid poly-ADP-ribosylation
namespace: biological_process
def: "This modification produces peptidyl-glutamic acid poly-ADP-ribose found in a number of nuclear proteins under certain conditions including the repair of single strand DNA breaks. The activated form of the generating enzyme poly(ADP-ribose) polymerase is itself modified in this way." [RESID:AA0295]
subset: gosubset_prok
xref: RESID:AA0295
is_a: GO:0006471 ! protein ADP-ribosylation
is_a: GO:0018200 ! peptidyl-glutamic acid modification

[Term]
id: GO:0018425
name: O3-(N-acetylglucosamine-1-phosphoryl)-L-serine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of O3-(N-acetylglucosamine-1-phosphoryl)-L-serine. The recovery of O-phosphorylserine from acid hydrolysates suggests N-acetylglucosamine-1-phosphate residues are esterified to peptidyl serines through phosphoester bonds." [RESID:AA0296]
subset: gosubset_prok
synonym: "O3-(N-acetylglucosamine-1-phosphoryl)-L-serine anabolism" EXACT []
synonym: "O3-(N-acetylglucosamine-1-phosphoryl)-L-serine biosynthesis" EXACT []
synonym: "O3-(N-acetylglucosamine-1-phosphoryl)-L-serine formation" EXACT []
synonym: "O3-(N-acetylglucosamine-1-phosphoryl)-L-serine synthesis" EXACT []
xref: RESID:AA0296
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0042077 ! protein phosphate-linked glycosylation via serine
is_a: GO:0042398 ! cellular modified amino acid biosynthetic process
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:0046349 ! amino sugar biosynthetic process
is_a: GO:0090407 ! organophosphate biosynthetic process

[Term]
id: GO:0018426
name: O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine. The polypeptide backbones of glycoproteins and mucin-like proteoglycans are extensively modified with a complex array of phosphoglycan chains that are linked to Ser/Thr-rich domains via a common Man-alpha1-PO4-Ser linkage." [RESID:AA0297]
subset: gosubset_prok
synonym: "O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine anabolism" EXACT []
synonym: "O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine biosynthesis" EXACT []
synonym: "O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine formation" EXACT []
synonym: "O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine synthesis" EXACT []
xref: RESID:AA0297
is_a: GO:0042077 ! protein phosphate-linked glycosylation via serine

[Term]
id: GO:0018427
name: copper incorporation into metallo-sulfur cluster
namespace: biological_process
def: "The incorporation of copper into a metallo-sulfur cluster." [GOC:ai]
subset: gosubset_prok
synonym: "copper incorporation into metallo-sulphur cluster" EXACT []
is_a: GO:0018282 ! metal incorporation into metallo-sulfur cluster

[Term]
id: GO:0018428
name: copper incorporation into copper-sulfur cluster
namespace: biological_process
def: "The incorporation of copper into a copper-sulfur cluster." [GOC:ai]
subset: gosubset_prok
synonym: "copper incorporation into copper-sulphur cluster" EXACT []
is_a: GO:0018427 ! copper incorporation into metallo-sulfur cluster

[Term]
id: GO:0018429
name: copper incorporation into copper-sulfur cluster via heptakis-L-histidino tetracopper mu4-sulfide hydroxide
namespace: biological_process
def: "The incorporation of copper into a 4Cu-S copper-sulfur cluster via heptakis-L-histidino tetracopper mu4-sulfide hydroxide." [RESID:AA0298]
subset: gosubset_prok
synonym: "copper incorporation into copper-sulphur cluster via heptakis-L-histidino tetracopper mu4-sulphide hydroxide" EXACT []
xref: RESID:AA0298
is_a: GO:0018202 ! peptidyl-histidine modification
is_a: GO:0018428 ! copper incorporation into copper-sulfur cluster

[Term]
id: GO:0018439
name: peptidyl-L-leucine methyl ester biosynthetic process from peptidyl-leucine
namespace: biological_process
alt_id: GO:0018440
def: "The modification of a C-terminal peptidyl-leucine to form peptidyl-L-leucine methyl ester." [RESID:AA0299]
synonym: "peptidyl-leucine esterification" EXACT []
xref: RESID:AA0299
is_a: GO:0006481 ! C-terminal protein methylation
is_a: GO:0018203 ! peptidyl-isoleucine modification
is_a: GO:0018350 ! protein esterification

[Term]
id: GO:0018441
name: iron incorporation into iron-sulfur cluster via hexakis-L-cysteinyl L-serinyl octairon heptasulfide
namespace: biological_process
def: "The incorporation of iron into a 8Fe-7S iron-sulfur cluster via hexakis-L-cysteinyl L-serinyl octairon heptasulfide, found in nitrogenase." [PMID:9063865, RESID:AA0300]
subset: gosubset_prok
synonym: "iron incorporation into iron-sulphur cluster via hexakis-L-cysteinyl L-serinyl octairon heptasulphide" EXACT []
xref: RESID:AA0300
is_a: GO:0018209 ! peptidyl-serine modification
is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster
is_a: GO:0018418 ! nickel incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide

[Term]
id: GO:0018442
name: peptidyl-glutamic acid esterification
namespace: biological_process
def: "The addition of an ester group to a glutamic acid residue in a protein." [GOC:mah]
subset: gosubset_prok
is_a: GO:0018200 ! peptidyl-glutamic acid modification
is_a: GO:0018350 ! protein esterification

[Term]
id: GO:0018443
name: enzyme active site formation via L-aspartic 4-phosphoric anhydride
namespace: biological_process
def: "The transient phosphorylation of peptidyl-aspartic acid to form L-aspartic 4-phosphoric anhydride." [RESID:AA0033]
subset: gosubset_prok
xref: RESID:AA0033
is_a: GO:0018217 ! peptidyl-aspartic acid phosphorylation
is_a: GO:0018307 ! enzyme active site formation

[Term]
id: GO:0018444
name: translation release factor complex
namespace: cellular_component
def: "A heterodimeric complex involved in the release of a nascent polypeptide chain from a ribosome." [ISBN:0198547684]
synonym: "eukaryotic peptide chain release factor" EXACT []
synonym: "peptide chain release factor" BROAD []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0018445
name: prothoracicotrophic hormone activity
namespace: molecular_function
def: "The action characteristic of prothoracicotrophic hormone, a peptide hormone that is secreted by the brain and, upon receptor binding, acts on the prothoracic gland to stimulate the release of ecdysone in insects." [GOC:mah, PMID:3301403]
is_a: GO:0005184 ! neuropeptide hormone activity

[Term]
id: GO:0018446
name: pinocarveol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: pinocarveol = pinocarvone + 2 H+ + 2 e-." [UM-BBD_reactionID:r0717]
xref: EC:1.1.-.-
xref: UM-BBD_reactionID:r0717
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0018447
name: chloral hydrate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reactions: chloral hydrate = 3 H+ + 2 e- + trichloroacetate, and chloral hydrate + H2 = H2O + trichloroethanol." [UM-BBD_enzymeID:e0229]
xref: EC:1.1.-.-
xref: UM-BBD_enzymeID:e0229
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0018448
name: hydroxymethylmethylsilanediol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydroxymethylmethylsilanediol + O2 + 2 H+ + 2 e- = formylmethylsilanediol + 2 H2O." [UM-BBD_reactionID:r0638]
xref: EC:1.1.-.-
xref: UM-BBD_reactionID:r0638
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0018449
name: 1-phenylethanol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-1-phenylethanol = acetophenone + H2." [UM-BBD_reactionID:r0032]
xref: EC:1.1.-.-
xref: UM-BBD_reactionID:r0032
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0018450
name: myrtenol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: myrtenol + O2 + 2 H+ + 2 e- = 2 H2O + myrtenal." [UM-BBD_reactionID:r0710]
xref: EC:1.1.-.-
xref: UM-BBD_reactionID:r0710
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0018451
name: epoxide dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: ethene oxide + NAD+ + CoA-SH = NADH + H+ + acetyl-CoA." [UM-BBD_reactionID:r0595]
xref: EC:1.1.1.-
xref: UM-BBD_reactionID:r0595
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018452
name: 5-exo-hydroxycamphor dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-exo-hydroxycamphor + NAD+ = NADH + H+ + 2,5-diketocamphane." [UM-BBD_reactionID:r0427]
xref: EC:1.1.1.-
xref: MetaCyc:R542-RXN
xref: UM-BBD_reactionID:r0427
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018453
name: 2-hydroxytetrahydrofuran dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxytetrahydrofuran = 2 H+ + 2 e- + butyrolactone." [UM-BBD_reactionID:r0018]
xref: EC:1.1.1.-
xref: UM-BBD_reactionID:r0018
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018454
name: acetoacetyl-CoA reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-3-hydroxyacyl-CoA + NADP+ = 3-oxoacyl-CoA + NADPH + H+." [EC:1.1.1.36]
subset: gosubset_prok
synonym: "(R)-3-hydroxyacyl-CoA dehydrogenase activity" EXACT [EC:1.1.1.36]
synonym: "(R)-3-hydroxyacyl-CoA:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.36]
synonym: "acetoacetyl coenzyme A reductase activity" EXACT [EC:1.1.1.36]
synonym: "beta-ketoacyl-CoA reductase" BROAD [EC:1.1.1.36]
synonym: "D(-)-beta-hydroxybutyryl CoA-NADP oxidoreductase activity" EXACT [EC:1.1.1.36]
synonym: "D-3-hydroxyacyl-CoA reductase activity" EXACT [EC:1.1.1.36]
synonym: "hydroxyacyl coenzyme-A dehydrogenase activity" EXACT [EC:1.1.1.36]
synonym: "NADP-linked acetoacetyl CoA reductase activity" EXACT [EC:1.1.1.36]
synonym: "NADPH:acetoacetyl-CoA reductase activity" EXACT [EC:1.1.1.36]
synonym: "short chain beta-ketoacetyl(acetoacetyl)-CoA reductase activity" EXACT [EC:1.1.1.36]
xref: EC:1.1.1.36
xref: MetaCyc:RXN-7698
xref: RHEA:22259
xref: UM-BBD_reactionID:r0202
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018455
name: alcohol dehydrogenase [NAD(P)+] activity
namespace: molecular_function
def: "Catalysis of the reaction: an alcohol + NAD(P)+ = an aldehyde + NAD(P)H + H+." [EC:1.1.1.71]
synonym: "alcohol:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.71]
synonym: "aldehyde reductase (NADPH/NADH)" EXACT [EC:1.1.1.71]
xref: EC:1.1.1.71
xref: MetaCyc:ALCOHOL-DEHYDROGENASE-NADP+-RXN
xref: RHEA:10739
xref: UM-BBD_reactionID:r0172
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018456
name: aryl-alcohol dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: an aromatic alcohol + NAD+ = an aromatic aldehyde + NADH + H+." [EC:1.1.1.90]
subset: gosubset_prok
synonym: "aryl-alcohol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.90]
synonym: "benzyl alcohol dehydrogenase activity" NARROW []
synonym: "p-hydroxybenzyl alcohol dehydrogenase activity" NARROW [EC:1.1.1.90]
xref: EC:1.1.1.90
xref: MetaCyc:ARYL-ALCOHOL-DEHYDROGENASE-RXN
xref: UM-BBD_enzymeID:e0019
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018457
name: perillyl-alcohol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(+) + perillyl alcohol = H(+) + NADH + perillyl aldehyde." [EC:1.1.1.144, RHEA:10667]
synonym: "perillyl alcohol dehydrogenase activity" EXACT [EC:1.1.1.144]
synonym: "perillyl-alcohol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.144]
xref: EC:1.1.1.144
xref: KEGG:R03945
xref: MetaCyc:PERILLYL-ALCOHOL-DEHYDROGENASE-RXN
xref: RHEA:10667
xref: UM-BBD_reactionID:r0729
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018458
name: isopiperitenol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (1S,6R)-isopiperitenol + NAD(+) = (6R)-isoperitenone + H(+) + NADH." [EC:1.1.1.223, RHEA:20863]
synonym: "(-)-trans-isopiperitenol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.223]
xref: EC:1.1.1.223
xref: KEGG:R03261
xref: MetaCyc:ISOPIPERITENOL-DEHYDROGENASE-RXN
xref: RHEA:20863
xref: UM-BBD_reactionID:r0740
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018459
name: carveol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (1S,5R)-carveol + NADP(+) = (R)-carvone + H(+) + NADPH." [EC:1.1.1.243, RHEA:13632]
synonym: "(-)-trans-carveol dehydrogenase activity" EXACT [EC:1.1.1.243]
synonym: "(-)-trans-carveol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.243]
xref: EC:1.1.1.243
xref: KEGG:R03114
xref: MetaCyc:CARVEOL-DEHYDROGENASE-RXN
xref: RHEA:13632
xref: UM-BBD_reactionID:r0714
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018460
name: cyclohexanol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyclohexanol + NAD+ = cyclohexanone + NADH + H+." [EC:1.1.1.245]
synonym: "cyclohexanol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.245]
xref: EC:1.1.1.245
xref: MetaCyc:CYCLOHEXANOL-DEHYDROGENASE-RXN
xref: RHEA:10047
xref: UM-BBD_reactionID:r0165
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018461
name: fluoren-9-ol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: fluoren-9-ol + 2 NADP+ = fluoren-9-one + 2 NADPH + 2 H+." [EC:1.1.1.256]
synonym: "9-fluorenol dehydrogenase activity" EXACT []
synonym: "fluoren-9-ol:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.256]
xref: EC:1.1.1.256
xref: MetaCyc:9-FLUORENOL-DEHYDROGENASE-RXN
xref: UM-BBD_reactionID:r0408
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018462
name: 4-(hydroxymethyl)benzenesulfonate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-(hydroxymethyl)benzenesulfonate + NAD(+) = 4-formylbenzenesulfonate + H(+) + NADH." [EC:1.1.1.257, RHEA:24415]
synonym: "4-(hydroxymethyl)benzenesulfonate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.257]
synonym: "4-(hydroxymethyl)benzenesulphonate dehydrogenase activity" EXACT []
synonym: "4-sulfobenzyl alcohol dehydrogenase activity" EXACT []
xref: EC:1.1.1.257
xref: KEGG:R05271
xref: MetaCyc:1.1.1.257-RXN
xref: RHEA:24415
xref: UM-BBD_reactionID:r0291
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018463
name: 6-hydroxyhexanoate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-hydroxyhexanoate + NAD(+) = 6-oxohexanoate + H(+) + NADH." [EC:1.1.1.258, RHEA:14228]
synonym: "6-hydroxyhexanoate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.258]
xref: EC:1.1.1.258
xref: KEGG:R05283
xref: MetaCyc:6-HYDROXYHEXANOATE-OXIDATION-RXN
xref: RHEA:14228
xref: UM-BBD_reactionID:r0174
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018464
name: 3-hydroxypimeloyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxypimelyl-CoA + NAD(+) = 3-oxopimelyl-CoA + H(+) + NADH." [EC:1.1.1.259, RHEA:11171]
synonym: "3-hydroxypimeloyl-CoA:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.259]
xref: EC:1.1.1.259
xref: KEGG:R05305
xref: MetaCyc:1.1.1.259-RXN
xref: RHEA:11171
xref: UM-BBD_reactionID:r0196
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018465
name: vanillyl-alcohol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: O(2) + vanillyl alcohol = H(2)O(2) + vanillin." [EC:1.1.3.38, RHEA:10039]
synonym: "4-hydroxy-2-methoxybenzyl alcohol oxidase activity" EXACT [EC:1.1.3.38]
synonym: "vanillyl alcohol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.38]
xref: EC:1.1.3.38
xref: KEGG:R02877
xref: MetaCyc:1.1.3.38-RXN
xref: RHEA:10039
xref: UM-BBD_reactionID:r0651
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0018466
name: limonene-1,2-diol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (1S,2S,4R)-limonene-1,2-diol + DCPIP+ = DCPIPH + H+ + (1S,4R)-1-hydroxy-2-oxolimonene." [UM-BBD_reactionID:r0735]
xref: EC:1.1.99.-
xref: UM-BBD_reactionID:r0735
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0018467
name: formaldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: formaldehyde + H(2)O + NAD(+) = formate + 2 H(+) + NADH." [EC:1.2.1.46, RHEA:16428]
subset: gosubset_prok
synonym: "formaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.46]
synonym: "glutathione-independent formaldehyde dehydrogenase activity" EXACT []
xref: EC:1.2.1.46
xref: KEGG:R00604
xref: MetaCyc:FORMALDEHYDE-DEHYDROGENASE-RXN
xref: RHEA:16428
xref: UM-BBD_reactionID:r0240
is_a: GO:0004029 ! aldehyde dehydrogenase (NAD) activity

[Term]
id: GO:0018468
name: alcohol dehydrogenase (acceptor) activity
namespace: molecular_function
def: "Catalysis of the reaction: a primary alcohol + acceptor = an aldehyde + reduced acceptor." [EC:1.1.99.8]
subset: mf_needs_review
synonym: "alcohol:(acceptor) oxidoreductase activity" EXACT [EC:1.1.99.8]
synonym: "alcohol:acceptor oxidoreductase activity" EXACT [EC:1.1.99.8]
synonym: "MDH" RELATED [EC:1.1.99.8]
synonym: "PQQ-dependent alcohol dehydrogenase activity" EXACT []
synonym: "primary alcohol dehydrogenase" BROAD [EC:1.1.99.8]
synonym: "quinohemoprotein alcohol dehydrogenase activity" EXACT [EC:1.1.99.8]
synonym: "quinoprotein alcohol dehydrogenase activity" EXACT [EC:1.1.99.8]
synonym: "quinoprotein ethanol dehydrogenase activity" EXACT [EC:1.1.99.8]
xref: EC:1.1.99.8
xref: UM-BBD_enzymeID:e0004
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0018469
name: myrtenal dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: myrtenal + H2O = 2 H+ + 2 e- + myrtenic acid." [UM-BBD_reactionID:r0711]
xref: EC:1.2.-.-
xref: UM-BBD_reactionID:r0711
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0018470
name: 4-hydroxybutaraldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxybutyraldehyde + H2O = 2 H+ + 2 e- + 4-hydroxybutanoate." [UM-BBD_reactionID:r0014]
xref: EC:1.2.-.-
xref: UM-BBD_reactionID:r0014
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0018471
name: 4-chlorobenzaldehyde oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-chlorobenzaldehyde + 2 H2O = 4-chlorobenzoate + 2 H+ + 2 e-." [UM-BBD_reactionID:r0447]
xref: EC:1.14.13.-
xref: UM-BBD_reactionID:r0447
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018472
name: 1-hydroxy-2-naphthaldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-hydroxy-2-naphthaldehyde + NAD+ + H2O = NADH + H+ + 1-hydroxy-2-naphthoate." [UM-BBD_reactionID:r0485]
xref: EC:1.2.1.-
xref: UM-BBD_reactionID:r0485
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018473
name: cis-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-2-methyl-5-isopropylhexa-2,5-dienal + NAD+ + H2O = NADH + H+ + cis-2-methyl-5-isopropylhexa-2,5-dienoic acid." [UM-BBD_reactionID:r0744]
xref: EC:1.2.1.-
xref: UM-BBD_reactionID:r0744
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018474
name: 2-carboxybenzaldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-carboxybenzaldehyde + NAD+ + H2O = NADH + 2 H+ + phthalate." [UM-BBD_reactionID:r0490]
xref: EC:1.2.1.-
xref: UM-BBD_reactionID:r0490
is_a: GO:0004029 ! aldehyde dehydrogenase (NAD) activity

[Term]
id: GO:0018475
name: trans-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-2-methyl-5-isopropylhexa-2,5-dienal + NAD+ + H2O = NADH + H+ + trans-2-methyl-5-isopropylhexa-2,5-dienoic acid." [UM-BBD_reactionID:r0745]
xref: EC:1.2.1.-
xref: UM-BBD_reactionID:r0745
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018477
name: benzaldehyde dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: benzaldehyde + NADP+ + H2O = benzoate + NADPH + H+." [EC:1.2.1.7]
synonym: "benzaldehyde:NADP+ oxidoreductase" EXACT [EC:1.2.1.7]
synonym: "NADP-linked benzaldehyde dehydrogenase" EXACT [EC:1.2.1.7]
xref: EC:1.2.1.7
xref: MetaCyc:BENZALDEHYDE-DEHYDROGENASE-NADP+-RXN
xref: RHEA:21663
xref: UM-BBD_enzymeID:e0079
is_a: GO:0033721 ! aldehyde dehydrogenase (NADP+) activity

[Term]
id: GO:0018478
name: malonate-semialdehyde dehydrogenase (acetylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-oxopropanoate + CoA + NADP+ = acetyl-CoA + CO2 + NADPH + H+." [EC:1.2.1.18]
subset: gosubset_prok
synonym: "3-oxopropanoate:NAD(P)+ oxidoreductase (decarboxylating, CoA-acetylating)" EXACT [EC:1.2.1.18]
synonym: "malonic semialdehyde oxidative decarboxylase activity" EXACT []
xref: EC:1.2.1.18
xref: MetaCyc:1.2.1.18-RXN
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018479
name: benzaldehyde dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: benzaldehyde + NAD+ + H2O = benzoate + NADH + H+." [EC:1.2.1.28]
subset: gosubset_prok
synonym: "benzaldehyde (NAD) dehydrogenase activity" EXACT [EC:1.2.1.28]
synonym: "benzaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.28]
xref: EC:1.2.1.28
xref: MetaCyc:BENZALDEHYDE-DEHYDROGENASE-NAD+-RXN
xref: RHEA:11843
xref: UM-BBD_reactionID:r0269
is_a: GO:0004029 ! aldehyde dehydrogenase (NAD) activity

[Term]
id: GO:0018480
name: 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+ = 5-carboxymethyl-2-hydroxymuconate + NADH + H+." [EC:1.2.1.60]
subset: gosubset_prok
synonym: "5-carboxymethyl-2-hydroxymuconic-semialdehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.60]
synonym: "carboxymethylhydroxymuconic semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.60]
xref: EC:1.2.1.60
xref: MetaCyc:CHMS-DEHYDROGENASE-RXN
xref: RHEA:15684
xref: UM-BBD_reactionID:r0365
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018481
name: 4-hydroxymuconic-semialdehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: <stereo>cis,trans</stereo>-4-hydroxymuconate semialdehyde + H(2)O + NAD(+) = 2 H(+) + maleylacetate + NADH." [EC:1.2.1.61, RHEA:22423]
subset: gosubset_prok
synonym: "4-hydroxymuconic-semialdehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.61]
xref: EC:1.2.1.61
xref: KEGG:R05236
xref: MetaCyc:1.2.1.61-RXN
xref: RHEA:22423
xref: UM-BBD_reactionID:r0229
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018482
name: 4-formylbenzenesulfonate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-formylbenzenesulfonate + H(2)O + NAD(+) = 4-sulfobenzoate + 2 H(+) + NADH." [EC:1.2.1.62, RHEA:18836]
synonym: "4-formylbenzenesulfonate:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.62]
synonym: "4-formylbenzenesulphonate dehydrogenase activity" EXACT []
synonym: "toluene-sulfonate aldehyde dehydrogenase activity" EXACT []
xref: EC:1.2.1.62
xref: KEGG:R05272
xref: MetaCyc:1.2.1.62-RXN
xref: RHEA:18836
xref: UM-BBD_reactionID:r0292
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018483
name: 6-oxohexanoate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-oxohexanoate + NADP+ + H2O = adipate + NADPH + H+." [EC:1.2.1.63]
synonym: "6-oxohexanoate:NADP+ oxidoreductase activity" EXACT [EC:1.2.1.63]
xref: EC:1.2.1.63
xref: MetaCyc:6-OXOHEXANOATE-OXIDATION-RXN
xref: RHEA:13400
xref: UM-BBD_reactionID:r0175
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018484
name: 4-hydroxybenzaldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxybenzaldehyde + NAD+ + H2O = 4-hydroxybenzoate + NADH + H+." [EC:1.2.1.64]
synonym: "3-hydroxybenzaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.64]
synonym: "p-hydroxybenzaldehyde dehydrogenase activity" EXACT [EC:1.2.1.64]
xref: EC:1.2.1.64
xref: MetaCyc:HYDROXYBENZALDEHYDE-OXIDATION-NAD-RXN
xref: RHEA:20308
xref: UM-BBD_reactionID:r0273
is_a: GO:0004029 ! aldehyde dehydrogenase (NAD) activity

[Term]
id: GO:0018485
name: salicylaldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: salicylaldehyde + NAD+ + H2O = salicylate + NADH + H+." [EC:1.2.1.65]
subset: gosubset_prok
synonym: "salicylaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.65]
xref: EC:1.2.1.65
xref: MetaCyc:1.2.1.65-RXN
xref: RHEA:18540
xref: UM-BBD_enzymeID:e0256
is_a: GO:0004029 ! aldehyde dehydrogenase (NAD) activity

[Term]
id: GO:0018486
name: 2-butanone oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: methyl ethyl ketone + O2 = H2O + ethyl acetate." [UM-BBD_reactionID:r0169]
xref: EC:1.2.3.-
xref: UM-BBD_reactionID:r0169
is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor

[Term]
id: GO:0018487
name: vanillate O-demethylase (anaerobic) activity
namespace: molecular_function
def: "Catalysis of the reaction: vanillate + Co+ = Co3+-CH3 + 3,4-dihydroxybenzoate." [UM-BBD_reactionID:r0758]
xref: EC:1.2.3.-
xref: UM-BBD_reactionID:r0758
is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor
is_a: GO:0032451 ! demethylase activity

[Term]
id: GO:0018488
name: aryl-aldehyde oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: an aromatic aldehyde + O2 + H2O = an aromatic acid + hydrogen peroxide." [EC:1.2.3.9]
synonym: "aryl-aldehyde:oxygen oxidoreductase activity" EXACT [EC:1.2.3.9]
xref: EC:1.2.3.9
xref: MetaCyc:ARYL-ALDEHYDE-OXIDASE-RXN
xref: UM-BBD_reactionID:r0145
is_a: GO:0004031 ! aldehyde oxidase activity

[Term]
id: GO:0018489
name: vanillate monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(+) + NADH + O(2) + vanillate = 3,4-dihydroxybenzoate + formaldehyde + H(2)O + NAD(+)." [EC:1.14.13.82, RHEA:13024]
comment: Note that this was EC:1.2.3.12.
subset: gosubset_prok
synonym: "4-hydroxy-3-methoxybenzoate demethylase activity" EXACT [EC:1.14.13.82]
synonym: "vanillate demethylase (aerobic) activity" EXACT []
synonym: "vanillate demethylase activity" EXACT []
synonym: "vanillate:oxygen oxidoreductase (demethylating)" EXACT [EC:1.14.13.82]
xref: EC:1.14.13.82
xref: KEGG:R05274
xref: MetaCyc:RXN-10891
xref: MetaCyc:RXN-2
xref: RHEA:13024
xref: UM-BBD_reactionID:r0146
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
is_a: GO:0032451 ! demethylase activity

[Term]
id: GO:0018490
name: 4-hydroxyphenylpyruvate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 (4-hydroxyphenyl)pyruvate + O(2) = 2 (4-hydroxyphenyl)acetate + 2 CO(2)." [EC:1.2.3.13, RHEA:17200]
synonym: "4-hydroxyphenylpyruvate:oxygen oxidoreductase (decarboxylating)" BROAD [EC:1.2.3.13]
xref: EC:1.2.3.13
xref: KEGG:R00042
xref: MetaCyc:1.2.3.13-RXN
xref: RHEA:17200
xref: UM-BBD_reactionID:r0299
is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor

[Term]
id: GO:0018491
name: 2-oxobutyrate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxobutanoate + CoA + oxidized ferredoxin = propanoyl-CoA + CO2 + reduced ferredoxin." [EC:1.2.7.2]
synonym: "2-ketobutyrate synthase activity" EXACT [EC:1.2.7.2]
synonym: "2-oxobutanoate:ferredoxin 2-oxidoreductase (CoA-propionylating)" EXACT [EC:1.2.7.2]
synonym: "2-oxobutyrate-ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.2]
synonym: "alpha-ketobutyrate synthase activity" EXACT [EC:1.2.7.2]
synonym: "alpha-ketobutyrate-ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.2]
xref: EC:1.2.7.2
xref: MetaCyc:2-OXOBUTYRATE-SYNTHASE-RXN
xref: UM-BBD_reactionID:r0358
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018492
name: carbon-monoxide dehydrogenase (acceptor) activity
namespace: molecular_function
def: "Catalysis of the reaction: CO + H2O + acceptor = CO2 + reduced acceptor." [EC:1.2.99.2]
subset: gosubset_prok
synonym: "anaerobic carbon monoxide dehydrogenase activity" EXACT [EC:1.2.99.2]
synonym: "carbon monoxide dehydrogenase activity" BROAD []
synonym: "carbon-monoxide:acceptor oxidoreductase activity" EXACT [EC:1.2.99.2]
xref: EC:1.2.99.2
xref: MetaCyc:CARBON-MONOXIDE-DEHYDROGENASE-RXN
xref: RHEA:17832
xref: UM-BBD_enzymeID:e0415
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0018493
name: formylmethanofuran dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-formylmethanofuran + A + H(2)O + H(+) = AH(2) + CO(2) + methanofuran." [EC:1.2.99.5, RHEA:19844]
subset: gosubset_prok
synonym: "formylmethanofuran:(acceptor) oxidoreductase activity" EXACT [EC:1.2.99.5]
synonym: "formylmethanofuran:acceptor oxidoreductase activity" EXACT [EC:1.2.99.5]
xref: EC:1.2.99.5
xref: KEGG:R03015
xref: MetaCyc:FORMYLMETHANOFURAN-DEHYDROGENASE-RXN
xref: RHEA:19844
xref: UM-BBD_reactionID:r0345
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0018494
name: carvone reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: carvone + 2 H+ + 2 e- = dihydrocarvone." [UM-BBD_reactionID:r0732]
xref: EC:1.3.-.-
xref: MetaCyc:RXN-9403
xref: MetaCyc:RXN-9419
xref: UM-BBD_reactionID:r0732
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0018495
name: 2-hydroxycyclohexane-1-carboxyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxycyclohexane-1-carboxyl-CoA = 2 H+ + 2 e- + 2-ketocyclohexane-1-carboxyl-CoA." [UM-BBD_reactionID:r0192]
xref: EC:1.3.-.-
xref: UM-BBD_reactionID:r0192
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0018496
name: 2,6-dihydroxycyclohexane-1-carboxyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,6-dihydroxycyclohexane-1-carboxyl-CoA = 2 H+ + 2 e- + 6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA." [UM-BBD_reactionID:r0205]
xref: EC:1.3.-.-
xref: UM-BBD_reactionID:r0205
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0018497
name: 1-chloro-2,2-bis(4-chlorophenyl)ethane dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-chloro-2,2-bis(4-chlorophenyl)ethene + 2 H+ + 2 e- = 1-chloro-2,2-bis(4-chlorophenyl)ethane. 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU; 1-chloro-2,2-bis(4-chlorophenyl)ethane is also known as DDMS." [UM-BBD_reactionID:r0514]
synonym: "DDMS dehydrogenase activity" EXACT []
xref: EC:1.3.-.-
xref: UM-BBD_reactionID:r0514
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0018498
name: 2,3-dihydroxy-2,3-dihydro-phenylpropionate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol + NAD+ = NADH + H+ + 3-(2,3-dihydroxyphenyl)propionate." [UM-BBD_enzymeID:e0308]
xref: EC:1.3.1.-
xref: MetaCyc:PHENPRODIOLDEHYDROG-RXN
xref: UM-BBD_enzymeID:e0308
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018499
name: cis-2,3-dihydrodiol DDT dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-2,3-dihydrodiol DDT + NADP+ = NADPH + 2,3-dihydroxy DDT." [UM-BBD_reactionID:r0451]
xref: EC:1.3.1.-
xref: UM-BBD_reactionID:r0451
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018500
name: trans-9R,10R-dihydrodiolphenanthrene dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-9R,10R-dihydrodiolphenanthrene + NAD+ = NADH + H+ + 9,10-dihydroxyphenanthrene." [UM-BBD_reactionID:r0575]
xref: EC:1.3.1.-
xref: UM-BBD_reactionID:r0575
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018501
name: cis-chlorobenzene dihydrodiol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the conversion of a di- or tetrachlorinated dienol to the corresponding catechol." [UM-BBD_enzymeID:e0411]
xref: EC:1.3.1.-
xref: UM-BBD_enzymeID:e0411
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018502
name: 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,5-dichloro-2,5-cyclohexadiene-1,4-diol + NAD+ = NADH + H+ + 2,5-dichlorohydroquinone." [UM-BBD_reactionID:r0553]
xref: EC:1.3.1.-
xref: MetaCyc:LINC-RXN
xref: UM-BBD_reactionID:r0553
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018503
name: trans-1,2-dihydrodiolphenanthrene dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-1,2-dihydrodiolphenanthrene + NAD+ = H+ + NADH + 1,2-dihydroxyphenanthrene." [UM-BBD_reactionID:r0574]
xref: EC:1.3.1.-
xref: UM-BBD_reactionID:r0574
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018504
name: cis-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-1,2-dihydrobenzene-1,2-diol + NAD+ = catechol + NADH + H+." [EC:1.3.1.19]
subset: gosubset_prok
synonym: "cis-1,2-dihydrobenzene-1,2-diol:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.19]
synonym: "cis-1,2-dihydrocyclohexa-3,5-diene (nicotinamide adenine dinucleotide) oxidoreductase activity" EXACT [EC:1.3.1.19]
synonym: "cis-benzene glycol dehydrogenase activity" EXACT [EC:1.3.1.19]
xref: EC:1.3.1.19
xref: MetaCyc:1.3.1.19-RXN
xref: UM-BBD_enzymeID:e0060
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018505
name: cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-1,2-dihydronaphthalene-1,2-diol + NAD+ = naphthalene-1,2-diol + NADH + H+." [EC:1.3.1.29]
synonym: "(+)-cis-naphthalene dihydrodiol dehydrogenase activity" EXACT [EC:1.3.1.29]
synonym: "1,2-dihydroxy-1,2-dihydroxynaphthalene dehydrogenase activity" EXACT []
synonym: "cis-1,2-dihydronaphthalene-1,2-diol:NAD+ 1,2-oxidoreductase activity" EXACT [EC:1.3.1.29]
synonym: "cis-dihydrodiol naphthalene dehydrogenase activity" EXACT [EC:1.3.1.29]
synonym: "cis-naphthalene dihydrodiol dehydrogenase activity" EXACT [EC:1.3.1.29]
synonym: "naphthalene dihydrodiol dehydrogenase activity" EXACT [EC:1.3.1.29]
xref: EC:1.3.1.29
xref: MetaCyc:1.3.1.29-RXN
xref: RHEA:11835
xref: UM-BBD_enzymeID:e0122
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018506
name: maleylacetate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-oxoadipate + NAD(P)+ = 2-maleylacetate + NAD(P)H + H+." [EC:1.3.1.32]
subset: gosubset_prok
synonym: "3-oxoadipate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.3.1.32]
synonym: "maleolylacetate reductase activity" EXACT [EC:1.3.1.32]
xref: EC:1.3.1.32
xref: MetaCyc:MALEYLACETATE-REDUCTASE-RXN
xref: UM-BBD_enzymeID:e0063
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018507
name: cis-3,4-dihydrophenanthrene-3,4-diol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3S,4R)-3,4-dihydrophenanthrene-3,4-diol + NAD(+) = H(+) + NADH + phenanthrene-3,4-diol." [EC:1.3.1.49, RHEA:16256]
synonym: "(+)-cis-3,4-dihydrophenanthrene-3,4-diol:NAD+ 3,4-oxidoreductase activity" EXACT [EC:1.3.1.49]
synonym: "cis-3,4-dihydroxy-3,4-dihydrophenanthrene dehydrogenase activity" EXACT []
xref: EC:1.3.1.49
xref: KEGG:R04151
xref: MetaCyc:1.3.1.49-RXN
xref: RHEA:16256
xref: UM-BBD_reactionID:r0488
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018508
name: cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate + NAD+ = catechol + CO2 + NADH + H+." [MetaCyc:BENZOATE-CIS-DIOL-DEHYDROGENASE-RXN]
subset: gosubset_prok
synonym: "benzoate cis-diol dehydrogenase activity" EXACT []
xref: UM-BBD_enzymeID:e0219
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018509
name: cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+ = biphenyl-2,3-diol + NADH + H+." [EC:1.3.1.56]
subset: gosubset_prok
synonym: "2,3-dihydro-2,3-dihydroxybiphenyl dehydrogenase activity" EXACT []
synonym: "biphenyl-2,3-dihydro-2,3-diol dehydrogenase activity" EXACT [EC:1.3.1.56]
synonym: "cis-3-phenylcyclohexa-3,5-diene-1,2-diol:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.56]
xref: EC:1.3.1.56
xref: MetaCyc:1.3.1.56-RXN
xref: RHEA:17036
xref: UM-BBD_enzymeID:e0134
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018510
name: phloroglucinol reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: dihydrophloroglucinol + NADP(+) = H(+) + NADPH + phloroglucinol." [EC:1.3.1.57, RHEA:10083]
subset: gosubset_prok
synonym: "dihydrophloroglucinol:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.57]
xref: EC:1.3.1.57
xref: KEGG:R05308
xref: MetaCyc:R5-RXN
xref: RHEA:10083
xref: UM-BBD_reactionID:r0007
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018511
name: 2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+) = 2,3-dihydroxy-p-cumate + H(+) + NADH." [EC:1.3.1.58, RHEA:23775]
subset: gosubset_prok
synonym: "cis-2,3-dihydroxy-2,3-dihydro-p-cumate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.58]
xref: EC:1.3.1.58
xref: KEGG:R05240
xref: MetaCyc:RXN-665
xref: RHEA:23775
xref: UM-BBD_reactionID:r0396
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018512
name: obsolete 1,6-dihydroxy-5-methylcyclohexa-2,4-dienecarboxylate dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1,6-dihydroxy-5-methylcyclohexa-2,4-dienecarboxylate + NAD+ = 3-methylcatechol + CO2 + NADH + H+." [EC:1.3.1.59]
comment: This term was made obsolete because, according to the Enzyme Commission, there is no evidence that this enzymatic activity exists.
synonym: "1,2-dihydroxy-3-methylcyclohexa-3,5-diene-carboxylate dehydrogenase activity" EXACT []
synonym: "1,6-dihydroxy-5-methylcyclohexa-2,4-dienecarboxylate dehydrogenase activity" EXACT []
xref: EC:1.3.1.59
xref: UM-BBD_reactionID:r0216
is_obsolete: true

[Term]
id: GO:0018513
name: dibenzothiophene dihydrodiol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene + NAD(+) = 1,2-dihydroxydibenzothiophene + H(+) + NADH." [EC:1.3.1.60, RHEA:24191]
subset: gosubset_prok
synonym: "cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.60]
xref: EC:1.3.1.60
xref: KEGG:R05310
xref: MetaCyc:1.3.1.60-RXN
xref: RHEA:24191
xref: UM-BBD_reactionID:r0161
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018515
name: pimeloyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(+) + pimelyl-CoA = 2,3-didehydropimeloyl-CoA + H(+) + NADH." [EC:1.3.1.62, RHEA:19668]
subset: gosubset_prok
synonym: "pimeloyl-CoA:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.62]
xref: EC:1.3.1.62
xref: KEGG:R05311
xref: MetaCyc:1.3.1.62-RXN
xref: RHEA:19668
xref: UM-BBD_reactionID:r0194
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018516
name: 2,4-dichlorobenzoyl-CoA reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-chlorobenzoyl-CoA + chloride + NADP(+) = 2,4-dichlorobenzoyl-CoA + NADPH." [EC:1.3.1.63, RHEA:23079]
synonym: "4-chlorobenzoyl-CoA:NADP+ oxidoreductase (halogenating)" EXACT [EC:1.3.1.63]
xref: EC:1.3.1.63
xref: KEGG:R05276
xref: MetaCyc:1.3.1.63-RXN
xref: RHEA:23079
xref: UM-BBD_reactionID:r0138
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018517
name: phthalate 4,5-cis-dihydrodiol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+) = 4,5-dihydroxyphthalate + H(+) + NADH." [EC:1.3.1.64, RHEA:13840]
synonym: "cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.64]
xref: EC:1.3.1.64
xref: KEGG:R05275
xref: MetaCyc:1.3.1.64-RXN
xref: RHEA:13840
xref: UM-BBD_reactionID:r0142
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018518
name: 5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,6-dihydroxy-3-methyl-5,6-dihydroquinolin-2(1H)-one + NAD(+) = 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + H(+) + NADH." [EC:1.3.1.65, RHEA:24559]
synonym: "5,6-dihydrodiol-3-methyl-2-oxo-1,2-dihydroquinoline dehydrogenase" RELATED []
synonym: "5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.65]
xref: EC:1.3.1.65
xref: KEGG:R05312
xref: MetaCyc:RXN-643
xref: RHEA:24559
xref: UM-BBD_reactionID:r0053
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018519
name: cis-dihydroethylcatechol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-1,2-dihydro-3-ethylcatechol + NAD(+) = 3-ethylcatechol + H(+) + NADH." [EC:1.3.1.66, RHEA:18104]
synonym: "cis-1,2-dihydro-3-ethylcatechol:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.66]
synonym: "cis-ethylbenzene glycol dehydrogenase activity" EXACT []
xref: EC:1.3.1.66
xref: KEGG:R05313
xref: MetaCyc:1.3.1.66-RXN
xref: RHEA:18104
xref: UM-BBD_reactionID:r0309
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018520
name: cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate + NADP+ = 4-methylcatechol + NADPH + H+ + CO2." [EC:1.3.1.67]
synonym: "4-methylcyclohexa-3,5-diene-1,2-cis-diol-1-carboxylic acid dehydrogenase activity" EXACT []
synonym: "cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate:NAD(P)+ oxidoreductase (decarboxylating)" EXACT [EC:1.3.1.67]
xref: EC:1.3.1.67
xref: MetaCyc:1.3.1.67-RXN
xref: UM-BBD_reactionID:r0179
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018521
name: 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,6-dihydroxy-2-methylcyclohexa-2,4-dienecarboxylate + NAD(+) = 3-methylcatechol + CO(2) + NADH." [EC:1.3.1.68, RHEA:15660]
synonym: "1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.3.1.68]
xref: EC:1.3.1.68
xref: KEGG:R05314
xref: MetaCyc:1.3.1.68-RXN
xref: RHEA:15660
xref: UM-BBD_reactionID:r0224
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018522
name: benzoyl-CoA reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 ADP + cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized ferredoxin + 2 phosphate = 2 ATP + 2 H(2)O + benzoyl-CoA + reduced ferredoxin." [EC:1.3.7.8]
synonym: "benzoyl-CoA reductase (dearomatizing) activity" EXACT [EC:1.3.7.8]
synonym: "cyclohexa-1,5-diene-1-carbonyl-CoA:ferredoxin oxidoreductase (aromatizing, ATP-forming) activity" EXACT [KEGG:R02451]
xref: EC:1.3.7.8
xref: KEGG:R02451
xref: MetaCyc:1.3.99.15-RXN
xref: UM-BBD_reactionID:r0190
is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0018523
name: quinoline 2-oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: quinoline + acceptor + H2O = isoquinolin-1(2H)-one + reduced acceptor." [EC:1.3.99.17]
subset: gosubset_prok
synonym: "quinoline:acceptor 2-oxidoreductase (hydroxylating)" EXACT [EC:1.3.99.17]
xref: EC:1.3.99.17
xref: MetaCyc:1.3.99.17-RXN
xref: UM-BBD_reactionID:r0045
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0018524
name: acetophenone carboxylase activity
namespace: molecular_function
alt_id: GO:0018797
def: "Catalysis of the reaction: acetophenone + CO2 = H+ + benzoyl acetate." [UM-BBD_reactionID:r0033]
xref: EC:6.4.1.-
xref: UM-BBD_reactionID:r0033
is_a: GO:0016885 ! ligase activity, forming carbon-carbon bonds

[Term]
id: GO:0018525
name: 4-hydroxybenzoyl-CoA reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzoyl-CoA + oxidized ferredoxin + H2O = 4-hydroxybenzoyl-CoA + reduced ferredoxin." [KEGG:R05316]
synonym: "4-hydroxybenzoyl-coA reductase (dehydroxylating) activity" EXACT [EC:1.3.7.9]
synonym: "4-hydroxybenzoyl-coA:(acceptor) oxidoreductase activity" EXACT [EC:1.3.7.9]
xref: EC:1.3.7.9
xref: KEGG:R05316
xref: MetaCyc:OHBENZCOARED-RXN
xref: UM-BBD_reactionID:r0158
is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0018526
name: 2-aminobenzoyl-CoA reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-aminobenzoyl-CoA + 2 H+ + 2 e- = NH3 + benzoyl-CoA." [UM-BBD_reactionID:r0342]
xref: EC:1.4.-.-
xref: UM-BBD_reactionID:r0342
is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors

[Term]
id: GO:0018527
name: cyclohexylamine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyclohexylamine + O2 + H2O = cyclohexanone + NH3 + hydrogen peroxide." [EC:1.4.3.12]
synonym: "cyclohexylamine:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.12]
xref: EC:1.4.3.12
xref: MetaCyc:CYCLOHEXYLAMINE-OXIDASE-RXN
xref: RHEA:18436
xref: UM-BBD_reactionID:r0754
is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

[Term]
id: GO:0018528
name: iminodiacetate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: iminodiacetate + OH- = H+ + 2 e- + glyoxylate + glycine." [UM-BBD_reactionID:r0589]
xref: EC:1.5.-.-
xref: UM-BBD_reactionID:r0589
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0018529
name: nitrilotriacetate monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: nitrilotriacetate + NADH + H+ + O2 = NAD+ + H2O + glyoxylate + iminodiacetate." [UM-BBD_reactionID:r0587]
xref: EC:1.5.1.-
xref: UM-BBD_reactionID:r0587
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018530
name: (R)-6-hydroxynicotine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-6-hydroxynicotine + H(2)O + O(2) = 6-hydroxypseudooxynicotine + H(2)O(2)." [EC:1.5.3.6, RHEA:10015]
subset: gosubset_prok
synonym: "(R)-6-hydroxynicotine:oxygen oxidoreductase activity" EXACT [EC:1.5.3.6]
synonym: "6-hydroxy-D-nicotine oxidase activity" EXACT []
synonym: "D-6-hydroxynicotine oxidase activity" EXACT [EC:1.5.3.6]
xref: EC:1.5.3.6
xref: KEGG:R07170
xref: MetaCyc:R-6-HYDROXYNICOTINE-OXIDASE-RXN
xref: RHEA:10015
xref: UM-BBD_reactionID:r0477
is_a: GO:0019116 ! hydroxy-nicotine oxidase activity

[Term]
id: GO:0018531
name: (S)-6-hydroxynicotine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-6-hydroxynicotine + H(2)O + O(2) = 6-hydroxypseudooxynicotine + H(2)O(2)." [EC:1.5.3.5, RHEA:11883]
subset: gosubset_prok
synonym: "(S)-6-hydroxynicotine:oxygen oxidoreductase activity" EXACT [EC:1.5.3.5]
synonym: "6-hydroxy-L-nicotine oxidase activity" EXACT []
synonym: "6-hydroxy-L-nicotine:oxygen oxidoreductase activity" EXACT [EC:1.5.3.5]
synonym: "L-6-hydroxynicotine oxidase activity" EXACT []
xref: EC:1.5.3.5
xref: KEGG:R03202
xref: MetaCyc:S-6-HYDROXYNICOTINE-OXIDASE-RXN
xref: RHEA:11883
xref: UM-BBD_reactionID:r0478
is_a: GO:0019116 ! hydroxy-nicotine oxidase activity

[Term]
id: GO:0018532
name: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: N5,N10-methenyltetrahydromethanopterin + H2 = N5,N10-methylenetetrahydromethanopterin." [UM-BBD_reactionID:r0353]
synonym: "coenzyme F420-independent 5,10-methenyl-5,6,7,8-tetrahydromethanopterin dehydrogenase activity" EXACT []
synonym: "coenzyme F420-independent methylene-H4MPT dehydrogenase activity" EXACT []
synonym: "F420-independent 5,10-methenyl-5,6,7,8-tetrahydromethanopterin dehydrogenase activity" EXACT []
synonym: "F420-independent methylene-H4MPT dehydrogenase activity" EXACT []
xref: EC:1.5.99.-
xref: UM-BBD_reactionID:r0353
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0018533
name: peptidyl-cysteine acetylation
namespace: biological_process
def: "The acetylation of peptidyl-cysteine." [GOC:mah]
subset: gosubset_prok
is_a: GO:0006473 ! protein acetylation
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018534
name: nitrilotriacetate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: nitrilotriacetate + OH- = H+ + 2 e- + glyoxylate + iminodiacetate." [UM-BBD_reactionID:r0588]
xref: EC:1.5.99.-
xref: UM-BBD_reactionID:r0588
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0018535
name: nicotine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: nicotine + acceptor + H2O = (S)-6-hydroxynicotine + reduced acceptor." [EC:1.5.99.4]
subset: gosubset_prok
synonym: "D-nicotine oxidase activity" EXACT [EC:1.5.99.4]
synonym: "nicotine oxidase activity" EXACT [EC:1.5.99.4]
synonym: "nicotine:(acceptor) 6-oxidoreductase (hydroxylating)" EXACT [EC:1.5.99.4]
synonym: "nicotine:acceptor 6-oxidoreductase (hydroxylating)" EXACT [EC:1.5.99.4]
xref: EC:1.5.99.4
xref: MetaCyc:NICOTINE-DEHYDROGENASE-RXN
xref: RHEA:14772
xref: UM-BBD_enzymeID:e0337
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0018537
name: coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-methyltetrahydromethanopterin + coenzyme F420 + H(+) = 5,10-methylenetetrahydromethanopterin + reduced coenzyme F420." [EC:1.5.99.11, RHEA:21147]
subset: gosubset_prok
synonym: "5,10-methylenetetrahydromethanopterin cyclohydrolase activity" EXACT [EC:1.5.99.11]
synonym: "5,10-methylenetetrahydromethanopterin reductase activity" EXACT [EC:1.5.99.11]
synonym: "5-methyltetrahydromethanopterin:coenzyme-F420 oxidoreductase activity" EXACT [EC:1.5.99.11]
synonym: "coenzyme F420-dependent N(5),N(10)-methenyltetrahydromethanopterin reductase activity" EXACT [EC:1.5.99.11]
synonym: "methylene-H(4)MPT reductase activity" EXACT [EC:1.5.99.11]
synonym: "methylene-H4MPT reductase activity" EXACT [EC:1.5.99.11]
synonym: "methylenetetrahydromethanopterin reductase activity" EXACT []
synonym: "N(5),N(10)-methylenetetrahydromethanopterin reductase activity" EXACT [EC:1.5.99.11]
synonym: "N(5),N(10)-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase activity" EXACT [EC:1.5.99.11]
synonym: "N5,N10-methylenetetrahydromethanopterin reductase activity" EXACT [EC:1.5.99.11]
synonym: "N5,N10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase activity" EXACT [EC:1.5.99.11]
xref: EC:1.5.99.11
xref: KEGG:R04464
xref: MetaCyc:METHELENE-THMPT-OXI-RXN
xref: RHEA:21147
xref: UM-BBD_reactionID:r0354
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0018538
name: epoxide carboxylase activity
namespace: molecular_function
def: "Catalysis of the generic reaction: epoxide + CO2 + NAD+ + electron donor = beta-keto acid + NADH + reduced electron donor; the electron donor may be NADPH or a dithiol. This reaction is the ring opening and carboxylation of an epoxide; for example: epoxypropane + CO2 + NAD+ + NADPH = acetoacetate + NADH + NADP+." [PMID:9555888]
xref: EC:1.6.-.-
is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H

[Term]
id: GO:0018541
name: p-benzoquinone reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,4-benzoquinone + H(+) + NADPH = hydroquinone + NADP(+)." [EC:1.6.5.6, RHEA:23491]
synonym: "NADPH:p-benzoquinone oxidoreductase activity" EXACT [EC:1.6.5.6]
xref: EC:1.6.5.6
xref: KEGG:R05244
xref: MetaCyc:1.6.5.6-RXN
xref: RHEA:23491
xref: UM-BBD_enzymeID:e0422
is_a: GO:0016655 ! oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor

[Term]
id: GO:0018542
name: 2,3-dihydroxy DDT 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-dihydroxy DDT + O2 = 6-oxo-2-hydroxy-7-(4-chlorophenyl)-3,8,8,8-tetrachloroocta-2E,4E-dienoate." [UM-BBD_reactionID:r0452]
xref: EC:1.13.11.-
xref: UM-BBD_reactionID:r0452
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018543
name: 4-amino-2-nitroso-6-nitrotoluene reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-amino-2-hydroxylamino-6-nitrotoluene + NADP+ = NADPH + H+ + 4-amino-2-nitroso-6-nitrotoluene." [UM-BBD_reactionID:r0464]
xref: EC:1.6.6.-
xref: UM-BBD_reactionID:r0464
is_a: GO:0016657 ! oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor

[Term]
id: GO:0018544
name: 4-carboxy-4'-sulfoazobenzene reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-carboxy-4'-sulfoazobenzene + 4 H+ + 4 e- = 4-aminobenzoate + 4-aminobenzenesulfonate." [UM-BBD_reactionID:r0543]
synonym: "4-carboxy-4'-sulphoazobenzene reductase activity" EXACT []
xref: EC:1.6.6.-
xref: UM-BBD_reactionID:r0543
is_a: GO:0016657 ! oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor

[Term]
id: GO:0018545
name: NAD(P)H nitroreductase activity
namespace: molecular_function
def: "Catalysis of the conversion of a nitrate group to an amino or hydroxylamino group on toluene or a toluene derivative." [UM-BBD_enzymeID:e0346]
xref: EC:1.6.6.-
xref: UM-BBD_enzymeID:e0346
is_a: GO:0016657 ! oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor

[Term]
id: GO:0018546
name: nitrobenzene nitroreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: nitrobenzene + 2 NADPH + 2 H+ = hydroxyaminobenzene + 2 NADP+ + H2O." [MetaCyc:RXN-8815]
xref: MetaCyc:RXN-8815
xref: UM-BBD_enzymeID:e0245
is_a: GO:0016657 ! oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor

[Term]
id: GO:0018547
name: nitroglycerin reductase activity
namespace: molecular_function
def: "Catalysis of the removal of one or more nitrite (NO2-) groups from nitroglycerin or a derivative." [UM-BBD_enzymeID:e0038]
synonym: "NG reductase activity" EXACT []
xref: EC:1.7.3.-
xref: UM-BBD_enzymeID:e0038
is_a: GO:0016663 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor

[Term]
id: GO:0018548
name: pentaerythritol trinitrate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: pentaerythritol trinitrate + NADPH = NADP+ + nitrate + pentaerythritol dinitrate." [UM-BBD_reactionID:r0025]
synonym: "xenobiotic reductase activity" BROAD [UM-BBD_enzymeID:e0028]
xref: EC:1.6.99.1
xref: UM-BBD_reactionID:r0025
is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors

[Term]
id: GO:0018549
name: methanethiol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: methanethiol + O2 + H2O = formaldehyde + hydrogen sulfide + hydrogen peroxide." [EC:1.8.3.4]
synonym: "(MM)-oxidase activity" EXACT [EC:1.8.3.4]
synonym: "methanethiol:oxygen oxidoreductase activity" EXACT [EC:1.8.3.4]
synonym: "methyl mercaptan oxidase activity" EXACT [EC:1.8.3.4]
synonym: "methylmercaptan oxidase activity" EXACT [EC:1.8.3.4]
synonym: "MT-oxidase activity" EXACT [EC:1.8.3.4]
xref: EC:1.8.3.4
xref: MetaCyc:METHANETHIOL-OXIDASE-RXN
xref: RHEA:11815
xref: UM-BBD_reactionID:r0209
is_a: GO:0016670 ! oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor

[Term]
id: GO:0018550
name: tetrachloro-p-hydroquinone reductive dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3,5,6-tetrachlorohydroquinone + 2 glutathione = 2,3,6-trichlorohydroquinone + glutathione disulfide + HCl." [UM-BBD_reactionID:r0314]
synonym: "tetrachlorohydroquinone reductive dehalogenase activity" EXACT []
xref: EC:1.8.99.-
xref: UM-BBD_reactionID:r0314
is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors

[Term]
id: GO:0018551
name: hydrogensulfite reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: trithionate + acceptor + 2 H2O + OH- = 3 HSO3- + reduced acceptor." [EC:1.8.99.3]
subset: gosubset_prok
synonym: "bisulfite reductase activity" EXACT [EC:1.8.99.3]
synonym: "desulfofuscidin activity" NARROW [EC:1.8.99.3]
synonym: "desulforubidin activity" NARROW [EC:1.8.99.3]
synonym: "desulfoviridin activity" NARROW [EC:1.8.99.3]
synonym: "dissimilatory sulfite reductase activity" EXACT []
synonym: "dissimilatory-type sulfite reductase activity" EXACT [EC:1.8.99.3]
synonym: "hydrogensulphite reductase activity" EXACT []
synonym: "trithionate:(acceptor) oxidoreductase activity" EXACT [EC:1.8.99.3]
synonym: "trithionate:acceptor oxidoreductase activity" EXACT [EC:1.8.99.3]
xref: EC:1.8.99.3
xref: MetaCyc:HYDROGENSULFITE-REDUCTASE-RXN
xref: RHEA:13212
xref: UM-BBD_reactionID:r0627
is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors

[Term]
id: GO:0018553
name: 3-(2,3-dihydroxyphenyl)propionate 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-(2,3-dihydroxyphenyl)propionate + O2 = 2-hydroxy-6-keto-nona-2,4-dienedioate." [UM-BBD_enzymeID:e0309]
xref: EC:1.13.-.-
xref: UM-BBD_enzymeID:e0309
is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
is_a: GO:0051213 ! dioxygenase activity

[Term]
id: GO:0018554
name: 1,2-dihydroxynaphthalene dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-dihydroxynaphthalene + O2 = 2-hydroxychromene-2-carboxylate. C6 of the substrate molecular may have an NH2 group attached." [UM-BBD_enzymeID:e0255]
xref: EC:1.13.-.-
xref: UM-BBD_enzymeID:e0255
is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
is_a: GO:0051213 ! dioxygenase activity

[Term]
id: GO:0018555
name: phenanthrene dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenanthrene + NADH + H+ + O2 = NAD+ + cis-3,4-dihydroxy-3,4-dihydrophenanthrene." [UM-BBD_reactionID:r0455]
xref: EC:1.13.11.-
xref: UM-BBD_reactionID:r0455
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018556
name: 2,2',3-trihydroxybiphenyl dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-dihydroxybenzenoid + O2 = H+ + distal extradiol ring cleavage. Substrates are 2,2',3-trihydroxybiphenyl (forms 2-hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate) and 2,2',3-trihydroxydiphenylether (forms 2,3-hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate)." [UM-BBD_enzymeID:e0032]
xref: EC:1.13.11.-
xref: UM-BBD_enzymeID:e0032
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018557
name: 1,2-dihydroxyfluorene 1,1-alpha-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-dihydroxyfluorene + O2 = 2-hydroxy-4-(2-oxo-1,3-dihydro-2H-inden-1-ylidene) but-2-enoic acid." [UM-BBD_reactionID:r0422]
xref: EC:1.13.11.-
xref: UM-BBD_reactionID:r0422
is_a: GO:0019117 ! dihydroxyfluorene dioxygenase activity

[Term]
id: GO:0018558
name: 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + O2 = 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon." [UM-BBD_reactionID:r0049]
xref: EC:1.13.11.-
xref: UM-BBD_reactionID:r0049
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018559
name: 1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,1-dichloro-2-(dihydroxy-4'-chorophenyl)-2-(4-chlorophenyl)ethene + O2 = 6-oxo-2-hydroxy-7-(4-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7-trienoate." [UM-BBD_reactionID:r0442]
synonym: "1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethylene 1,2-dioxygenase activity" EXACT []
xref: EC:1.13.11.-
xref: UM-BBD_reactionID:r0442
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018560
name: protocatechuate 3,4-dioxygenase type II activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-sulfocatechol + O2 = 3-sulfomuconate." [UM-BBD_reactionID:r0581]
xref: EC:1.13.11.-
xref: UM-BBD_reactionID:r0581
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018561
name: 2'-aminobiphenyl-2,3-diol 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2'-aminobiphenyl-2,3-diol + O2 = H+ + 2-hydroxy-6-oxo-(2'-aminophenyl)-hexa-2,4-dienoate." [UM-BBD_reactionID:r0457]
xref: EC:1.13.11.-
xref: UM-BBD_reactionID:r0457
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018562
name: 3,4-dihydroxyfluorene 4,4-alpha-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,4-dihydroxyfluorene + O2 = 2-hydroxy-4-(1-oxo-1,3-dihydro-2H-inden-2-ylidene) but-2-enoic acid." [UM-BBD_reactionID:r0415]
xref: EC:1.13.11.-
xref: UM-BBD_reactionID:r0415
is_a: GO:0019117 ! dihydroxyfluorene dioxygenase activity

[Term]
id: GO:0018563
name: 2,3-dihydroxy-ethylbenzene 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-dihydroxyethylbenzene + O2 = H+ + 2-hydroxy-6-oxoocta-2,4-dienoate." [UM-BBD_reactionID:r0310]
xref: EC:1.13.11.-
xref: UM-BBD_reactionID:r0310
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018564
name: carbazole 1,9a-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: carbazole + NADH + O2 + H+ = NAD+ + 2'-aminobiphenyl-2,3-diol." [UM-BBD_reactionID:r0456]
synonym: "carbazole 1,9alpha-dioxygenase activity" EXACT []
xref: EC:1.13.11.-
xref: UM-BBD_reactionID:r0456
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018565
name: dihydroxydibenzothiophene dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-dihydroxydibenzothiophene + O2 = cis-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate." [UM-BBD_reactionID:r0162]
xref: EC:1.13.11.-
xref: UM-BBD_reactionID:r0162
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018566
name: 1,2-dihydroxynaphthalene-6-sulfonate 1,8a-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-dihydroxynaphthalene-6-sulfonate + O2 = H+ + (Z)-4-(2-hydroxy-5-sulfonatophenyl)-2-oxo-3-butenoate." [UM-BBD_reactionID:r0324]
synonym: "1,2-dihydroxynaphthalene-6-sulphonate 1,8a-dioxygenase activity" EXACT []
xref: EC:1.13.11.-
xref: UM-BBD_reactionID:r0324
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018567
name: styrene dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: styrene + O2 + NADH + H+ = NAD+ + styrene cis-glycol." [UM-BBD_reactionID:r0256]
xref: EC:1.13.11.-
xref: UM-BBD_reactionID:r0256
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018568
name: 3,4-dihydroxyphenanthrene dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,4-dihydroxyphenanthrene + O2 = H+ + 2-hydroxy-2 H-benzo[h]chromene-2-carboxylate." [UM-BBD_reactionID:r0501]
xref: EC:1.13.11.-
xref: UM-BBD_reactionID:r0501
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018569
name: hydroquinone 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydroquinone + O2 = cis,trans-4-hydroxymuconic semialdehyde." [UM-BBD_reactionID:r0228]
xref: EC:1.13.11.-
xref: UM-BBD_reactionID:r0228
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018570
name: p-cumate 2,3-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: p-cumate + NADH + H+ + O2 = NAD+ + cis-2,3-dihydroxy-2,3-dihydro-p-cumate." [UM-BBD_reactionID:r0395]
xref: EC:1.13.11.-
xref: MetaCyc:RXN-664
xref: UM-BBD_reactionID:r0395
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018571
name: 2,3-dihydroxy-p-cumate dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-dihydroxy-p-cumate + O2 = 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate." [MetaCyc:RXN-666, UM-BBD_reactionID:r0397]
subset: gosubset_prok
synonym: "2,3-dihydroxy-p-cumate 3,4-dioxygenase" EXACT []
synonym: "2,3-dihydroxy-p-cumate-3,4-dioxygenase" EXACT []
xref: EC:1.13.11.-
xref: MetaCyc:RXN-666
xref: UM-BBD_reactionID:r0397
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018572
name: 3,5-dichlorocatechol 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,5-dichlorocatechol + O2 = 2 H+ + 2,4-dichloro-cis,cis-muconate." [UM-BBD_reactionID:r0276]
xref: EC:1.13.11.-
xref: UM-BBD_reactionID:r0276
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018573
name: 2-aminophenol 1,6-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-aminophenol + O2 = 2-aminomuconic semialdehyde." [UM-BBD_reactionID:r0305]
xref: EC:1.13.11.-
xref: UM-BBD_reactionID:r0305
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018574
name: 2,6-dichloro-p-hydroquinone 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,6-dichlorohydroquinone + O2 + H2O = HCl + 2 H+ + 2-chloromaleylacetate." [UM-BBD_enzymeID:e0422]
xref: EC:1.13.11.-
xref: UM-BBD_enzymeID:e0422
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018575
name: chlorocatechol 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,6-dichlorocatechol + O2 = 2 H+ + 2,5-dichloro-cis,cis-muconate." [UM-BBD_reactionID:r0655]
xref: EC:1.13.11.-
xref: UM-BBD_reactionID:r0655
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018576
name: catechol 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: catechol + O2 = cis,cis-muconate." [EC:1.13.11.1]
subset: gosubset_prok
synonym: "1,2-pyrocatechase activity" EXACT [EC:1.13.11.1]
synonym: "catechase activity" RELATED [EC:1.13.11.1]
synonym: "catechol 1,2-oxygenase activity" EXACT [EC:1.13.11.1]
synonym: "catechol-oxygen 1,2-oxidoreductase activity" EXACT [EC:1.13.11.1]
synonym: "catechol:oxygen 1,2-oxidoreductase activity" EXACT [EC:1.13.11.1]
synonym: "CD I" RELATED [EC:1.13.11.1]
synonym: "CD II" RELATED [EC:1.13.11.1]
synonym: "pyrocatechase activity" RELATED [EC:1.13.11.1]
synonym: "pyrocatechol 1,2-dioxygenase activity" EXACT [EC:1.13.11.1]
xref: EC:1.13.11.1
xref: MetaCyc:CATECHOL-12-DIOXYGENASE-RXN
xref: RHEA:23855
xref: UM-BBD_enzymeID:e0064
is_a: GO:0019114 ! catechol dioxygenase activity

[Term]
id: GO:0018577
name: catechol 2,3-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: catechol + O2 = 2-hydroxymuconate semialdehyde." [EC:1.13.11.2]
subset: gosubset_prok
synonym: "2,3-pyrocatechase activity" EXACT [EC:1.13.11.2]
synonym: "catechol 2,3-oxygenase" EXACT [EC:1.13.11.2]
synonym: "catechol oxygenase" EXACT [EC:1.13.11.2]
synonym: "catechol:oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.2]
synonym: "cato2ase activity" RELATED [EC:1.13.11.2]
synonym: "metapyrocatechase activity" RELATED [EC:1.13.11.2]
synonym: "pyrocatechol 2,3-dioxygenase" EXACT [EC:1.13.11.2]
xref: EC:1.13.11.2
xref: MetaCyc:CATECHOL-23-DIOXYGENASE-RXN
xref: RHEA:17340
xref: UM-BBD_enzymeID:e0156
is_a: GO:0019114 ! catechol dioxygenase activity

[Term]
id: GO:0018578
name: protocatechuate 3,4-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,4-dihydroxybenzoate + O2 = 3-carboxy-cis,cis-muconate." [EC:1.13.11.3]
subset: gosubset_prok
synonym: "protocatechuate oxygenase activity" BROAD [EC:1.13.11.3]
synonym: "protocatechuate:oxygen 3,4-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.3]
synonym: "protocatechuic 3,4-dioxygenase activity" EXACT [EC:1.13.11.3]
synonym: "protocatechuic 3,4-oxygenase activity" EXACT [EC:1.13.11.3]
synonym: "protocatechuic acid oxidase activity" EXACT [EC:1.13.11.3]
xref: EC:1.13.11.3
xref: MetaCyc:PROTOCATECHUATE-34-DIOXYGENASE-RXN
xref: RHEA:10087
xref: UM-BBD_reactionID:r0143
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018579
name: protocatechuate 4,5-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: protocatechuate + O2 = 4-carboxy-2-hydroxymuconate semialdehyde." [EC:1.13.11.8]
subset: gosubset_prok
synonym: "protocatechuate 4,5-oxygenase activity" EXACT [EC:1.13.11.8]
synonym: "protocatechuate:oxygen 4,5-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.8]
synonym: "protocatechuic 4,5-dioxygenase activity" EXACT [EC:1.13.11.8]
synonym: "protocatechuic 4,5-oxygenase activity" EXACT [EC:1.13.11.8]
xref: EC:1.13.11.8
xref: MetaCyc:PROTOCATECHUATE-45-DIOXYGENASE-RXN
xref: RHEA:24047
xref: UM-BBD_reactionID:r0144
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018580
name: nitronate monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: ethylnitronate + O(2) = acetaldehyde + nitrite." [EC:1.13.12.16, RHEA:28770]
comment: Where non-covalently bound FMN is used as the cofactor, see instead 'nitronate monooxygenase (FMN-linked) activity ; GO:0036434'.
subset: gosubset_prok
synonym: "2-nitropropane dioxygenase activity" RELATED [EC:1.13.11.32]
synonym: "nitronate:oxygen 2-oxidoreductase (nitrite-forming) activity" EXACT systematic_synonym [EC:1.13.12.16]
xref: EC:1.13.12.16
xref: MetaCyc:2-NITROPROPANE-DIOXYGENASE-RXN
xref: RHEA:28770
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)

[Term]
id: GO:0018581
name: hydroxyquinol 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzene-1,2,4-triol + O2 = 3-hydroxy-cis,cis-muconate." [EC:1.13.11.37]
subset: gosubset_prok
synonym: "benzene-1,2,4-triol:oxygen 1,2-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.37]
synonym: "hydroxyquinol dioxygenase activity" EXACT [EC:1.13.11.37]
xref: EC:1.13.11.37
xref: MetaCyc:HYDROXYQUINOL-12-DIOXYGENASE-RXN
xref: RHEA:19444
xref: UM-BBD_reactionID:r0232
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018582
name: 1-hydroxy-2-naphthoate 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-hydroxy-2-naphthoate + O2 = (3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate." [EC:1.13.11.38]
synonym: "1-hydroxy-2-naphthoate dioxygenase activity" EXACT []
synonym: "1-hydroxy-2-naphthoate-degrading enzyme activity" NARROW [EC:1.13.11.38]
synonym: "1-hydroxy-2-naphthoate:oxygen 1,2-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.38]
synonym: "1-hydroxy-2-naphthoic acid dioxygenase activity" EXACT [EC:1.13.11.38]
xref: EC:1.13.11.38
xref: MetaCyc:1.13.11.38-RXN
xref: RHEA:14752
xref: UM-BBD_reactionID:r0486
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018583
name: biphenyl-2,3-diol 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: biphenyl-2,3-diol + O2 = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H2O." [EC:1.13.11.39]
subset: gosubset_prok
synonym: "2,3-dihydroxybiphenyl 1,2-dioxygenase activity" BROAD []
synonym: "2,3-dihydroxybiphenyl dioxygenase activity" BROAD [EC:1.13.11.39]
synonym: "biphenyl-2,3-diol dioxygenase activity" EXACT [EC:1.13.11.39]
synonym: "biphenyl-2,3-diol:oxygen 1,2-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.39]
xref: EC:1.13.11.39
xref: MetaCyc:BIPHENYL-23-DIOL-12-DIOXYGENASE-RXN
xref: RHEA:14416
xref: UM-BBD_enzymeID:e0127
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018584
name: 2,4,5-trichlorophenoxyacetic acid oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4,5-trichlorophenoxyacetic acid + 1/2 O2 = glyoxylate + 2,4,5-trichlorophenol." [UM-BBD_reactionID:r0359]
xref: EC:1.13.99.-
xref: UM-BBD_reactionID:r0359
is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen

[Term]
id: GO:0018585
name: fluorene oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: fluorene + 2 H+ + 2 e- + O2 = H2O + 9-fluorenol." [UM-BBD_reactionID:r0407]
xref: EC:1.14.-.-
xref: UM-BBD_reactionID:r0407
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0018586
name: mono-butyltin dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: butyltin + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutyltin." [UM-BBD_reactionID:r0647]
synonym: "MBT dioxygenase activity" EXACT []
xref: EC:1.14.-.-
xref: UM-BBD_reactionID:r0647
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0018587
name: obsolete limonene 8-monooxygenase activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it was derived from a UM-BBD enzyme entry that has been deleted, and no other information can be found to suggest that it is a naturally occurring activity.
synonym: "limonene 8-monooxygenase activity" EXACT []
xref: EC:1.14.-.-
xref: UM-BBD_enzymeID:e0466
is_obsolete: true
replaced_by: GO:0019113

[Term]
id: GO:0018588
name: tri-n-butyltin dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: tri-n-butyltin + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutyldibutyltin." [UM-BBD_reactionID:r0643]
synonym: "TBT dioxygenase activity" EXACT []
xref: EC:1.14.-.-
xref: UM-BBD_reactionID:r0643
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0018589
name: di-n-butyltin dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: dibutyltin + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutylbutyltin." [UM-BBD_reactionID:r0645]
synonym: "DBT dioxygenase activity" EXACT []
xref: EC:1.14.-.-
xref: UM-BBD_reactionID:r0645
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0018590
name: methylsilanetriol hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: methylsilanetriol + O2 + 2 H+ + 2 e- = H2O + hydroxymethylsilanetriol." [UM-BBD_reactionID:r0640]
xref: EC:1.14.-.-
xref: UM-BBD_reactionID:r0640
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0018591
name: methyl tertiary butyl ether 3-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: methyl tert-butyl ether + 1/2 O2 = tert-butyl alcohol + formaldehyde." [UM-BBD_reactionID:r1023]
synonym: "MTBE 3-monooxygenase activity" EXACT []
xref: EC:1.14.-.-
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0018592
name: 4-nitrocatechol 4-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-nitrocatechol + O2 + 4 e- + 3 H+ = H2O + nitrite + 1,2,4-benzenetriol." [UM-BBD_reactionID:r0231]
xref: EC:1.14.-.-
xref: UM-BBD_reactionID:r0231
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0018593
name: 4-chlorophenoxyacetate monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-chlorophenoxyacetate + 1/2 O2 = glyoxylate + 4-chlorophenol." [UM-BBD_reactionID:r0281]
xref: EC:1.14.-.-
xref: UM-BBD_reactionID:r0281
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0018594
name: tert-butanol 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: tert-butanol + 1/2 O2 = 2-methyl-2-hydroxy-1-propanol." [UM-BBD_reactionID:r0615]
synonym: "tert-butyl alcohol 2-monooxygenase activity" EXACT []
xref: EC:1.14.-.-
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0018595
name: alpha-pinene monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-pinene + O2 + 2 H+ + 2 e- = H2O + pinocarveol." [UM-BBD_reactionID:r0716]
xref: EC:1.14.-.-
xref: UM-BBD_reactionID:r0716
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0018596
name: dimethylsilanediol hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: dimethylsilanediol + O2 + 2 H+ + 2 e- = H2O + hydroxymethylmethylsilanediol." [UM-BBD_reactionID:r0637]
synonym: "DMSD hydroxylase activity" EXACT []
xref: EC:1.14.-.-
xref: UM-BBD_reactionID:r0637
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0018597
name: ammonia monooxygenase activity
namespace: molecular_function
def: "Catalysis of the oxidation of alkanes (up to C8) to alcohols and alkenes (up to C5) to epoxides and alcohols in the presence of ammonium ions." [PMID:16347810]
subset: gosubset_prok
xref: EC:1.14.-.-
xref: UM-BBD_enzymeID:e0061
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0018598
name: hydroxymethylsilanetriol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydroxymethylsilanetriol + O2 + 2 H+ + 2 e- = 2 H2O + formylsilanetriol." [UM-BBD_reactionID:r0641]
xref: EC:1.14.-.-
xref: UM-BBD_reactionID:r0641
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0018599
name: 2-hydroxyisobutyrate 3-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxyisobutyrate + 1/2 O2 = 2,3-dihydroxy-2-methyl propionate." [UM-BBD_reactionID:r0619]
xref: EC:1.14.-.-
xref: UM-BBD_reactionID:r0619
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0018600
name: alpha-pinene dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-pinene + O2 + 2 H+ + 2 e- = H2O + myrtenol." [UM-BBD_reactionID:r0709]
xref: EC:1.14.-.-
xref: UM-BBD_reactionID:r0709
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0018601
name: 4-nitrophenol 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-nitrophenol + H(+) + NADH + O(2) = 4-nitrocatechol + H(2)O + NAD(+)." [EC:1.14.13.29, RHEA:12571]
synonym: "4-nitrophenol hydroxylase activity" EXACT [EC:1.14.13.29]
synonym: "4-nitrophenol,NADH:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.13.29]
synonym: "4-nitrophenol-2-hydroxylase activity" EXACT [EC:1.14.13.29]
xref: EC:1.14.13.29
xref: KEGG:R03023
xref: MetaCyc:4-NITROPHENOL-2-MONOOXYGENASE-RXN
xref: RHEA:12571
xref: UM-BBD_reactionID:r0230
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018602
name: 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4-dichlorophenoxyacetate + 2-oxoglutarate + oxygen = 2,4-dichlorophenol + glyoxylate + succinate + CO2." [UM-BBD_reactionID:r0274]
xref: EC:1.14.11.-
xref: MetaCyc:RXN-9863
xref: UM-BBD_reactionID:r0274
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0018603
name: nitrobenzene 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: nitrobenzene + NADH + O2 = NAD+ + nitrite + catechol." [UM-BBD_reactionID:r0306]
xref: EC:1.14.12.-
xref: UM-BBD_reactionID:r0306
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018604
name: 4-aminobenzoate 3,4-dioxygenase (deaminating) activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-aminobenzoate + 2 H+ + O2 + 2 e- = NH3 + 3,4-dihydroxybenzoate." [UM-BBD_reactionID:r0566]
xref: EC:1.14.12.-
xref: UM-BBD_reactionID:r0566
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018606
name: benzenesulfonate dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: toluene-4-sulfonate + NADH + O2 + H+ = NAD+ + HSO3(-) + 4-methylcatechol." [UM-BBD_reactionID:r0295]
synonym: "benzenesulphonate dioxygenase activity" EXACT []
xref: EC:1.14.12.-
xref: UM-BBD_reactionID:r0295
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018607
name: 1-indanone monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-indanone + NADPH + 1/2 O2 = NADP+ + 3,4-dihydrocoumarin." [UM-BBD_reactionID:r0417]
xref: EC:1.14.12.-
xref: UM-BBD_reactionID:r0417
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018608
name: 1-indanone dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-indanone + NADPH + 1/2 O2 = NADP+ + 3-hydroxy-1-indanone." [UM-BBD_reactionID:r0416]
xref: EC:1.14.12.-
xref: UM-BBD_reactionID:r0416
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018609
name: chlorobenzene dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-unsubstituted benzenoid + O2 + NAD(P)H + H+ = 2,3-cis-dihydroxydihydrobenzenoid + NAD(P)+. Substrates include 1,4-dichlorobenzene (forms 3,6-dichloro-cis-1,2-dihydroxycyclohexa-3,5-diene), 1,2,3,4-tetrachlorobenzene (forms cis-chlorobenzene dihydrodiol) and 1,2,4-trichlorobenzene (forms 3,4,6-trichloro-cis-1,2-dihydroxycyclohexa-3,5-diene)." [UM-BBD_enzymeID:e0062]
xref: EC:1.14.12.-
xref: UM-BBD_enzymeID:e0062
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018610
name: dibenzofuran 4,4a-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: dibenzofuran + NADH + H+ + O2 = 2,2',3-trihydroxybiphenyl + NAD+." [MetaCyc:R606-RXN]
xref: EC:1.14.12.-
xref: MetaCyc:R606-RXN
xref: UM-BBD_enzymeID:e0030
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018611
name: toluate dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: methylbenzoate + NADH + O2 + H+ = NAD+ + 1,2-dihydroxymethylcyclohexa-3,5-dienecarboxylate." [UM-BBD_enzymeID:e0190]
xref: EC:1.14.12.-
xref: UM-BBD_enzymeID:e0190
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018612
name: dibenzothiophene dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: dibenzothiophene + NADH + O2 + H+ = NAD+ + cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene." [UM-BBD_reactionID:r0160]
xref: EC:1.14.12.-
xref: UM-BBD_reactionID:r0160
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018613
name: 9-fluorenone dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 9-fluorenone + 2 NADPH + O2 = 2 NADP+ + 3,4-dihydroxy-3,4-dihydro-9-fluorenone." [UM-BBD_reactionID:r0409]
xref: EC:1.14.12.-
xref: UM-BBD_reactionID:r0409
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018614
name: ethylbenzene dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: ethylbenzene + O2 + NADH + H+ = NAD+ + cis-2,3-dihydroxy-2,3-dihydroethylbenzene." [UM-BBD_reactionID:r0247]
xref: EC:1.14.12.-
xref: UM-BBD_reactionID:r0247
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018615
name: 2-indanone monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-indanone + NADPH + 1/2 O2 = NADP+ + 3-isochromanone." [UM-BBD_reactionID:r0424]
xref: EC:1.14.12.-
xref: UM-BBD_reactionID:r0424
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018616
name: trihydroxytoluene dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3,5-trihydroxytoluene + O2 = 2,4,6-trioxoheptanoate." [MetaCyc:R305-RXN, UM-BBD_reactionID:r0093]
xref: EC:1.14.12.-
xref: MetaCyc:R305-RXN
xref: UM-BBD_reactionID:r0093
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018617
name: 4-aminobenzenesulfonate 3,4-dioxygenase (deaminating) activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-aminobenzenesulfonate + 2 H+ + O2 + 2 e- = NH3 + 4-sulfocatechol." [UM-BBD_reactionID:r0580]
synonym: "4-aminobenzenesulphonate 3,4-dioxygenase (deaminating) activity" EXACT []
xref: EC:1.14.12.-
xref: UM-BBD_reactionID:r0580
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018618
name: anthranilate 1,2-dioxygenase (deaminating, decarboxylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: anthranilate + NADPH + H+ + O2 = catechol + CO2 + NADP+ + NH3." [EC:1.14.12.1]
subset: gosubset_prok
synonym: "AntA" RELATED []
synonym: "AntB" RELATED []
synonym: "AntC" RELATED []
synonym: "anthranilate 1,2-dioxygenase" RELATED []
synonym: "anthranilate dioxygenase activity" EXACT []
synonym: "anthranilate dioxygenase reductase" NARROW []
synonym: "anthranilate hydroxylase activity" BROAD [EC:1.14.12.1]
synonym: "anthranilate,NAD(P)H:oxygen oxidoreductase (1,2-hydroxylating, deaminating, decarboxylating)" EXACT [EC:1.14.12.1]
synonym: "anthranilic acid hydroxylase activity" BROAD [EC:1.14.12.1]
synonym: "anthranilic hydroxylase activity" BROAD [EC:1.14.12.1]
xref: EC:1.14.12.1
xref: MetaCyc:1.14.12.1-RXN
xref: UM-BBD_reactionID:r0577
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018619
name: benzene 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzene + H(+) + NADH + O(2) = cis-cyclohexa-3,5-diene-1,2-diol + NAD(+)." [EC:1.14.12.3, RHEA:13816]
subset: gosubset_prok
synonym: "benzene dioxygenase activity" EXACT [EC:1.14.12.3]
synonym: "benzene hydroxylase activity" RELATED [EC:1.14.12.3]
synonym: "benzene,NADH:oxygen oxidoreductase (1,2-hydroxylating)" EXACT [EC:1.14.12.3]
xref: EC:1.14.12.3
xref: KEGG:R03543
xref: MetaCyc:BENZENE-12-DIOXYGENASE-RXN
xref: RHEA:13816
xref: UM-BBD_reactionID:r0079
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018620
name: phthalate 4,5-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(+) + NADH + O(2) + phthalate = cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+)." [EC:1.14.12.7, RHEA:17492]
subset: gosubset_prok
synonym: "PDO activity" EXACT [EC:1.14.12.7]
synonym: "phthalate dioxygenase activity" BROAD [EC:1.14.12.7]
synonym: "phthalate,NADH:oxygen oxidoreductase (4,5-hydroxylating)" EXACT [EC:1.14.12.7]
xref: EC:1.14.12.7
xref: KEGG:R03630
xref: MetaCyc:PHTHALATE-45-DIOXYGENASE-RXN
xref: RHEA:17492
xref: UM-BBD_reactionID:r0102
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018621
name: 4-sulfobenzoate 3,4-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-sulfobenzoate + H(+) + NADH + O(2) = 3,4-dihydroxybenzoate + NAD(+) + sulfite." [EC:1.14.12.8, RHEA:13940]
synonym: "4-sulfobenzoate 3,4-dioxygenase system" RELATED [EC:1.14.12.8]
synonym: "4-sulfobenzoate dioxygenase activity" EXACT [EC:1.14.12.8]
synonym: "4-sulfobenzoate,NADH:oxygen oxidoreductase (3,4-hydroxylating, sulfite-forming)" EXACT [EC:1.14.12.8]
synonym: "4-sulphobenzoate 3,4-dioxygenase activity" EXACT []
xref: EC:1.14.12.8
xref: KEGG:R01636
xref: MetaCyc:4-SULFOBENZOATE-34-DIOXYGENASE-RXN
xref: RHEA:13940
xref: UM-BBD_reactionID:r0293
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018622
name: 4-chlorophenylacetate 3,4-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-chlorophenylacetate + NADH + O(2) = 3,4-dihydroxyphenylacetate + chloride + NAD(+)." [EC:1.14.12.9, RHEA:14692]
synonym: "4-chlorophenylacetate,NADH:oxygen oxidoreductase (3,4-hydroxylating, dechlorinating)" EXACT [EC:1.14.12.9]
xref: EC:1.14.12.9
xref: KEGG:R03306
xref: MetaCyc:1.14.12.9-RXN
xref: RHEA:14692
xref: UM-BBD_reactionID:r0308
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018623
name: benzoate 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzoate + NADH + H+ + O2 = catechol + CO2 + NAD+." [EC:1.14.12.10]
subset: gosubset_prok
synonym: "benzoate dioxygenase activity" EXACT [EC:1.14.12.10]
synonym: "benzoate hydroxylase activity" EXACT [EC:1.14.12.10]
synonym: "benzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating)" EXACT [EC:1.14.12.10]
synonym: "benzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating, decarboxylating)" EXACT [EC:1.14.12.10]
synonym: "benzoic hydroxylase activity" EXACT [EC:1.14.12.10]
xref: EC:1.14.12.10
xref: MetaCyc:BENZOATE-12-DIOXYGENASE-RXN
xref: RHEA:12636
xref: UM-BBD_enzymeID:e0154
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018624
name: toluene dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(+) + NADH + O(2) + toluene = (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+)." [EC:1.14.12.11, RHEA:16740]
synonym: "toluene 1,2-dioxygenase activity" EXACT [EC:1.14.12.11]
synonym: "toluene 2,3-dioxygenase activity" EXACT [EC:1.14.12.11]
synonym: "toluene,NADH:oxygen oxidoreductase (1,2-hydroxylating)" EXACT [EC:1.14.12.11]
xref: EC:1.14.12.11
xref: KEGG:R03559
xref: MetaCyc:TOLUENE-DIOXYGENASE-RXN
xref: RHEA:16740
xref: UM-BBD_enzymeID:e0155
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018625
name: naphthalene 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: naphthalene + NADH + H+ + O2 = (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD+." [EC:1.14.12.12]
subset: gosubset_prok
synonym: "naphthalene dioxygenase activity" EXACT [EC:1.14.12.12]
synonym: "naphthalene oxygenase activity" EXACT [EC:1.14.12.12]
synonym: "naphthalene,NADH:oxygen oxidoreductase (1,2-hydroxylating)" EXACT [EC:1.14.12.12]
xref: EC:1.14.12.12
xref: MetaCyc:NAPHTHALENE-12-DIOXYGENASE-RXN
xref: RHEA:19176
xref: UM-BBD_enzymeID:e0002
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018626
name: 2-chlorobenzoate 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-chlorobenzoate + NADH + H+ + O2 = catechol + chloride + NAD+ + CO2." [EC:1.14.12.13]
subset: gosubset_prok
synonym: "2-chlorobenzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating, dechlorinating, decarboxylating)" EXACT [EC:1.14.12.13]
synonym: "2-halobenzoate 1,2-dioxygenase activity" EXACT []
xref: EC:1.14.12.13
xref: MetaCyc:2-CHLOROBENZOATE-12-DIOXYGENASE-RXN
xref: RHEA:21655
xref: UM-BBD_reactionID:r0632
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018627
name: 2-aminobenzenesulfonate 2,3-dioxygenase activity
namespace: molecular_function
alt_id: GO:0018605
def: "Catalysis of the reaction: 2-aminobenzenesulfonate + 2 H(+) + NADH + O(2) = 2,3-dihydroxybenzenesulfonate + NAD(+) + NH(4)(+). 2,3-dihydroxybenzenesulfonate is also known as 3-sulfocatechol." [EC:1.14.12.14, RHEA:23471]
synonym: "2-aminobenzenesulfonate dioxygenase activity" EXACT []
synonym: "2-aminobenzenesulfonate,NADH:oxygen oxidoreductase (2,3-hydroxylating, ammonia-forming)" EXACT [EC:1.14.12.14]
synonym: "2-aminobenzenesulphonate 2,3-dioxygenase activity" EXACT []
synonym: "2-aminobenzenesulphonate dioxygenase activity" EXACT []
synonym: "2-aminosulfobenzene 2,3-dioxygenase activity" EXACT [EC:1.14.12.14]
xref: EC:1.14.12.14
xref: KEGG:R05156
xref: MetaCyc:2ASDOSALCAL-RXN
xref: RHEA:23471
xref: UM-BBD_reactionID:r0218
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018628
name: terephthalate 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(+) + NADH + O(2) + terephthalate = (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+)." [EC:1.14.12.15, RHEA:10315]
synonym: "1,4-dicarboxybenzoate 1,2-dioxygenase activity" EXACT [EC:1.14.12.15]
synonym: "benzene-1,4-dicarboxylate 1,2-dioxygenase activity" EXACT [EC:1.14.12.15]
synonym: "benzene-1,4-dicarboxylate,NADH:oxygen oxidoreductase (1,2-hydroxylating)" EXACT [EC:1.14.12.15]
xref: EC:1.14.12.15
xref: KEGG:R05148
xref: MetaCyc:1.14.12.15-RXN
xref: RHEA:10315
xref: UM-BBD_reactionID:r0150
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018629
name: 2-hydroxyquinoline 5,6-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: quinolin-2-ol + NADH + H+ + O2 = 2,5,6-trihydroxy-5,6-dihydroquinoline + NAD+." [EC:1.14.12.16]
synonym: "2-oxo-1,2-dihydroquinoline 5,6-dioxygenase activity" EXACT []
synonym: "quinolin-2(1H)-one 5,6-dioxygenase activity" EXACT [EC:1.14.12.16]
synonym: "quinolin-2-ol 5,6-dioxygenase activity" EXACT [EC:1.14.12.16]
synonym: "quinolin-2-ol,NADH:oxygen oxidoreductase (5,6-hydroxylating)" EXACT [EC:1.14.12.16]
xref: EC:1.14.12.16
xref: MetaCyc:1.14.12.16-RXN
xref: RHEA:10979
xref: UM-BBD_reactionID:r0052
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018630
name: 3,5-xylenol methylhydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxytoluene + NADH + O2 = NAD+ + OH- + 3-hydroxybenzyl alcohol." [UM-BBD_reactionID:r0081]
xref: EC:1.14.13.-
xref: MetaCyc:3-5-XYLENOL-METHYLHYDROXYLASE-RXN
xref: UM-BBD_reactionID:r0081
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018631
name: phenylacetate hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenylacetate + NADH + O2 = NAD+ + OH- + 2-hydroxyphenylacetate." [UM-BBD_reactionID:r0036]
xref: EC:1.14.13.-
xref: UM-BBD_reactionID:r0036
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018632
name: 4-nitrophenol 4-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: p-nitrophenol + O2 + NADPH = H2O + NADP+ + nitrite + p-benzoquinone." [UM-BBD_reactionID:r0226]
xref: EC:1.14.13.-
xref: MetaCyc:RXN-8739
xref: UM-BBD_reactionID:r0226
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018633
name: dimethyl sulfide monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: dimethyl sulfide + NADH + O2 = NAD+ + OH- + methanethiol + formaldehyde." [UM-BBD_reactionID:r0208]
synonym: "dimethyl sulphide monooxygenase activity" EXACT []
xref: EC:1.14.13.-
xref: UM-BBD_reactionID:r0208
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018634
name: alpha-pinene monooxygenase [NADH] activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-pinene + NADH + H+ + O2 = NAD+ + H2O + alpha-pinene oxide." [UM-BBD_reactionID:r0742]
xref: EC:1.14.13.-
xref: UM-BBD_reactionID:r0742
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018635
name: (R)-limonene 1,2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (4R)-limonene + NAD(P)H + H+ + O2 = NAD(P)+ + H2O + (4R)-limonene-1,2-epoxide." [UM-BBD_enzymeID:e0462]
synonym: "(+)-limonene 1,2-monooxygenase activity" EXACT [EC:1.14.13.107]
synonym: "(+)-limonene,NAD(P)H:oxygen oxidoreductase activity" EXACT systematic_synonym [EC:1.14.13.107]
synonym: "(R)-limonene,NAD(P)H:oxygen oxidoreductase activity" EXACT systematic_synonym [EC:1.14.13.107]
xref: EC:1.14.13.107
xref: KEGG:R06398 "limonene,NADH:oxygen oxidoreductase"
xref: KEGG:R09393 "limonene,NADPH:oxygen oxidoreductase"
xref: MetaCyc:RXN-9407
xref: RHEA:26096 "limonene,NADH:oxygen oxidoreductase"
xref: RHEA:26100 "limonene,NADPH:oxygen oxidoreductase"
xref: UM-BBD_reactionID:r0733
is_a: GO:0019113 ! limonene monooxygenase activity

[Term]
id: GO:0018636
name: phenanthrene 9,10-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-9,10-oxide." [UM-BBD_reactionID:r0495]
xref: EC:1.14.13.-
xref: UM-BBD_reactionID:r0495
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018637
name: 1-hydroxy-2-naphthoate hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-hydroxy-2-naphthoate + O2 + NADPH + 2 H+ = NADP+ + H2O + CO2 + 1,2-dihydroxynaphthalene." [UM-BBD_reactionID:r0491]
xref: EC:1.14.13.-
xref: UM-BBD_reactionID:r0491
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018638
name: toluene 4-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: toluene + 1/2 O2 = 4-hydroxytoluene." [UM-BBD_enzymeID:e0225]
xref: EC:1.14.13.-
xref: UM-BBD_enzymeID:e0225
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018639
name: xylene monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reactions: toluene + 1/2 O2 = benzyl alcohol, and xylene + 1/2 O2 = methylbenzyl alcohol." [UM-BBD_enzymeID:e0172]
xref: EC:1.14.13.-
xref: UM-BBD_enzymeID:e0172
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018640
name: dibenzothiophene monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: dibenzothiophene + NADH + H+ + O2 = dibenzothiophene-5-oxide + NAD+ + H2O." [MetaCyc:RXN-621]
xref: EC:1.14.13.-
xref: MetaCyc:RXN-621
xref: UM-BBD_enzymeID:e0214
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018641
name: 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + O2 + 2 H+ + 2 e- = H2O + 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline." [UM-BBD_reactionID:r0048]
xref: EC:1.14.13.-
xref: UM-BBD_reactionID:r0048
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018642
name: chlorophenol 4-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the addition or substitution of an OH group on C4 of a halogenated phenol." [UM-BBD_enzymeID:e0252]
xref: EC:1.14.13.-
xref: UM-BBD_enzymeID:e0252
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018643
name: carbon disulfide oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: carbon disulfide + NADH + H+ + O2 = [S] + H2O + NAD+ + carbonyl sulfide." [UM-BBD_reactionID:r0599]
synonym: "carbon disulphide oxygenase activity" EXACT []
xref: EC:1.14.13.-
xref: UM-BBD_reactionID:r0599
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018644
name: toluene 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: toluene + 1/2 O2 = 2-hydroxytoluene." [UM-BBD_enzymeID:e0222]
xref: EC:1.14.13.-
xref: MetaCyc:TOLUENE-2-MONOOXYGENASE-RXN
xref: UM-BBD_enzymeID:e0222
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018645
name: alkene monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: propene + NADH + H+ + O2 = 1,2-epoxypropane + NAD+ + H2O." [EC:1.14.13.69]
synonym: "alkene epoxygenase activity" EXACT [EC:1.14.13.69]
synonym: "alkene,NADH:oxygen oxidoreductase activity" EXACT [EC:1.14.13.69]
xref: EC:1.14.13.69
xref: MetaCyc:1.14.13.69-RXN
xref: RHEA:11795
xref: UM-BBD_enzymeID:e0039
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018646
name: 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (1S,4R)-1-hydroxy-2-oxolimonene + NADPH + O2 = NADP+ + OH- + (3R)-3-isopropenyl-6-oxoheptanoate." [UM-BBD_reactionID:r0736]
xref: EC:1.14.13.-
xref: UM-BBD_reactionID:r0736
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018647
name: phenanthrene 1,2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-1,2-oxide." [UM-BBD_enzymeID:e0333]
xref: EC:1.14.13.-
xref: UM-BBD_enzymeID:e0333
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018648
name: methanesulfonate monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: methanesulfonate + NADH + H+ + O2 = formaldehyde + NAD+ + sulfite + H2O." [EC:1.14.13.111]
synonym: "mesylate monooxygenase activity" EXACT [EC:1.14.13.111]
synonym: "methanesulfonate,FMNH2:oxygen oxidoreductase activity" EXACT [EC:1.14.13.111]
synonym: "methanesulfonate,NADH:oxygen oxidoreductase activity" EXACT systematic_synonym [EC:1.14.13.111]
synonym: "methanesulfonic acid monooxygenase activity" EXACT [EC:1.14.13.111]
synonym: "methanesulphonic acid monooxygenase activity" EXACT [GOC:mah]
synonym: "MSA monooxygenase activity" EXACT [EC:1.14.13.111]
synonym: "MSAMO activity" EXACT [EC:1.14.13.111]
xref: EC:1.14.13.111
xref: MetaCyc:RXN-9770
xref: RHEA:26080
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018649
name: tetrahydrofuran hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: tetrahydrofuran + O2 + 2 H+ + 2 e- = H2O + 2-hydroxytetrahydrofuran." [UM-BBD_reactionID:r0017]
xref: EC:1.14.13.-
xref: UM-BBD_reactionID:r0017
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018650
name: styrene monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: styrene + NADPH + FADH + O2 = NADP+ + FAD+ + H2O + styrene oxide." [UM-BBD_reactionID:r0225]
xref: EC:1.14.13.-
xref: UM-BBD_reactionID:r0225
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018651
name: toluene-4-sulfonate monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: toluene-4-sulfonate + 1/2 O2 + H+ = HSO3(-) + 4-hydroxytoluene." [UM-BBD_reactionID:r0296]
synonym: "toluene-4-sulphonate monooxygenase activity" EXACT []
xref: EC:1.14.13.-
xref: UM-BBD_reactionID:r0296
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018652
name: toluene-sulfonate methyl-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: toluene-4-sulfonate + NADH + O2 = NAD+ + OH- + 4-sulfobenzyl alcohol." [UM-BBD_reactionID:r0290]
synonym: "toluene-sulphonate methyl-monooxygenase activity" EXACT []
xref: EC:1.14.13.-
xref: MetaCyc:TSMOS-RXN
xref: UM-BBD_reactionID:r0290
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018653
name: 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-methyl-2-oxo-1,2-dihydroquinoline + O2 + 2 H+ + 2 e- = H2O + 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline." [EC:1.14.13.-]
xref: EC:1.14.13.-
xref: UM-BBD_reactionID:r0046
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018654
name: 2-hydroxy-phenylacetate hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxyphenylacetate + NADH + O2 = NAD+ + OH- + homogentisate." [UM-BBD_reactionID:r0252]
xref: EC:1.14.13.-
xref: UM-BBD_reactionID:r0252
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018655
name: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA + NADH + H+ + O2 = NAD+ + H2O + delta2,5-3,4,4-trimethylpimelyl-CoA." [UM-BBD_reactionID:r0430]
xref: EC:1.14.13.-
xref: UM-BBD_reactionID:r0430
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018656
name: phenanthrene 3,4-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-3,4-oxide." [UM-BBD_reactionID:r0508]
xref: EC:1.14.13.-
xref: UM-BBD_reactionID:r0508
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018657
name: toluene 3-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: toluene + 1/2 O2 = 3-hydroxytoluene." [UM-BBD_enzymeID:e0224]
xref: EC:1.14.13.-
xref: MetaCyc:TOLUENE-3-MONOOXYGENASE-RXN
xref: UM-BBD_enzymeID:e0224
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018658
name: salicylate 1-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: salicylate + NADH + H+ + O2 = catechol + NAD+ + H2O + CO2." [EC:1.14.13.1]
subset: gosubset_prok
synonym: "salicylate 1-hydroxylase activity" EXACT [EC:1.14.13.1]
synonym: "salicylate hydroxylase (decarboxylating)" EXACT [EC:1.14.13.1]
synonym: "salicylate hydroxylase activity" EXACT []
synonym: "salicylate monooxygenase activity" EXACT [EC:1.14.13.1]
synonym: "salicylate,NADH:oxygen oxidoreductase (1-hydroxylating, decarboxylating)" EXACT [EC:1.14.13.1]
synonym: "salicylic hydroxylase activity" EXACT [EC:1.14.13.1]
xref: EC:1.14.13.1
xref: MetaCyc:SALICYLATE-1-MONOOXYGENASE-RXN
xref: RHEA:11007
xref: UM-BBD_enzymeID:e0149
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018659
name: 4-hydroxybenzoate 3-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxybenzoate + NADPH + H+ + O2 = protocatechuate + NADP+ + H2O." [EC:1.14.13.2]
subset: gosubset_prok
synonym: "4-hydroxybenzoate 3-hydroxylase activity" BROAD [EC:1.14.13.2]
synonym: "4-hydroxybenzoate monooxygenase activity" EXACT [EC:1.14.13.2]
synonym: "4-hydroxybenzoate,NADPH:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.2]
synonym: "p-hydroxybenzoate hydrolyase activity" EXACT [EC:1.14.13.2]
synonym: "p-hydroxybenzoate hydroxylase activity" BROAD [EC:1.14.13.2]
synonym: "p-hydroxybenzoate-3-hydroxylase activity" EXACT [EC:1.14.13.2]
synonym: "p-hydroxybenzoic acid hydrolase activity" EXACT [EC:1.14.13.2]
synonym: "p-hydroxybenzoic acid hydroxylase activity" BROAD [EC:1.14.13.2]
synonym: "p-hydroxybenzoic hydroxylase activity" EXACT [EC:1.14.13.2]
synonym: "para-hydroxybenzoate hydroxylase activity" BROAD [EC:1.14.13.2]
xref: EC:1.14.13.2
xref: MetaCyc:4-HYDROXYBENZOATE-3-MONOOXYGENASE-RXN
xref: RHEA:19480
xref: UM-BBD_reactionID:r0109
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018660
name: 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxyphenylacetate + NADH + H+ + O2 = 3,4-dihydroxyphenylacetate + NAD+ + H2O." [KEGG:R02698]
synonym: "4 HPA 3-hydroxylase activity" BROAD [EC:1.14.13.3]
synonym: "4-hydroxyphenylacetate 3-hydroxylase activity" BROAD []
synonym: "4-hydroxyphenylacetate 3-monooxygenase activity" BROAD [EC:1.14.13.3]
synonym: "p-hydroxyphenylacetate 3-hydroxylase activity" BROAD [EC:1.14.13.3]
synonym: "p-hydroxyphenylacetate hydroxylase activity" BROAD [EC:1.14.13.3]
xref: EC:1.14.13.-
xref: KEGG:R02698
xref: RHEA:16684
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018661
name: orcinol 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(+) + NADH + O(2) + orcinol = 2,3,5-trihydroxytoluene + H(2)O + NAD(+)." [EC:1.14.13.6, RHEA:19604]
synonym: "orcinol hydroxylase activity" EXACT []
synonym: "orcinol,NADH:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.13.6]
xref: EC:1.14.13.6
xref: KEGG:R02830
xref: MetaCyc:ORCINOL-2-MONOOXYGENASE-RXN
xref: RHEA:19604
xref: UM-BBD_reactionID:r0092
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018662
name: phenol 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenol + NADPH + H+ + O2 = catechol + NADP+ + H2O." [EC:1.14.13.7]
subset: gosubset_prok
synonym: "phenol hydroxylase activity" EXACT [EC:1.14.13.7]
synonym: "phenol o-hydroxylase activity" EXACT [EC:1.14.13.7]
synonym: "phenol,NADPH:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.13.7]
xref: EC:1.14.13.7
xref: MetaCyc:PHENOL-2-MONOOXYGENASE-RXN
xref: RHEA:17064
xref: UM-BBD_enzymeID:e0208
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018663
name: 2,6-dihydroxypyridine 3-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,6-dihydroxypyridine + H(+) + NADH + O(2) = 2,3,6-trihydroxypyridine + H(2)O + NAD(+)." [EC:1.14.13.10, RHEA:16920]
synonym: "2,6-dihydroxypyridine oxidase activity" EXACT []
synonym: "2,6-dihydroxypyridine,NADH:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.10]
xref: EC:1.14.13.10
xref: KEGG:R04130
xref: MetaCyc:1.14.13.10-RXN
xref: RHEA:16920
xref: UM-BBD_reactionID:r0479
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018664
name: benzoate 4-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzoate + H(+) + NADPH + O(2) = 4-hydroxybenzoate + H(2)O + NADP(+)." [EC:1.14.13.12, RHEA:18036]
synonym: "4-hydroxybenzoic hydroxylase activity" EXACT []
synonym: "benzoate 4-hydroxylase activity" EXACT [EC:1.14.13.12]
synonym: "benzoate,NADPH:oxygen oxidoreductase (4-hydroxylating)" EXACT [EC:1.14.13.12]
synonym: "benzoate-p-hydroxylase activity" EXACT [EC:1.14.13.12]
synonym: "benzoate-para-hydroxylase activity" EXACT [EC:1.14.13.12]
synonym: "benzoic 4-hydroxylase activity" EXACT [EC:1.14.13.12]
synonym: "benzoic acid 4-hydroxylase activity" EXACT [EC:1.14.13.12]
synonym: "p-hydroxybenzoate hydroxylase activity" EXACT [EC:1.14.13.12]
xref: EC:1.14.13.12
xref: KEGG:R01295
xref: MetaCyc:BENZOATE-4-MONOOXYGENASE-RXN
xref: RHEA:18036
xref: UM-BBD_reactionID:r0623
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018665
name: 4-hydroxyphenylacetate 1-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxyphenylacetate + NADPH + H+ + O2 = homogentisate + NADP+ + H2O." [EC:1.14.13.18]
synonym: "4-HPA 1-hydroxylase activity" EXACT [EC:1.14.13.18]
synonym: "4-hydroxyphenyl-acetate 1-hydroxylase activity" EXACT []
synonym: "4-hydroxyphenylacetate 1-hydroxylase activity" EXACT [EC:1.14.13.18]
synonym: "4-hydroxyphenylacetate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating)" EXACT [EC:1.14.13.18]
synonym: "4-hydroxyphenylacetic 1-hydroxylase activity" EXACT [EC:1.14.13.18]
xref: EC:1.14.13.18
xref: MetaCyc:1.14.13.18-RXN
xref: UM-BBD_reactionID:r0300
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018666
name: 2,4-dichlorophenol 6-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4-dichlorophenol + NADPH + H+ + O2 = 3,5-dichlorocatechol + NADP+ + H2O." [EC:1.14.13.20]
subset: gosubset_prok
synonym: "2,4-dichlorophenol hydroxylase activity" EXACT []
synonym: "2,4-dichlorophenol monooxygenase activity" EXACT [EC:1.14.13.20]
synonym: "2,4-dichlorophenol,NADPH:oxygen oxidoreductase (6-hydroxylating)" EXACT [EC:1.14.13.20]
xref: EC:1.14.13.20
xref: MetaCyc:24-DICHLOROPHENOL-6-MONOOXYGENASE-RXN
xref: RHEA:20923
xref: UM-BBD_enzymeID:e0152
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018667
name: cyclohexanone monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyclohexanone + NADPH + H+ + O2 = 6-hexanolide + NADP+ + H2O." [EC:1.14.13.22]
subset: gosubset_prok
synonym: "cyclohexanone 1,2-monooxygenase activity" EXACT []
synonym: "cyclohexanone oxygenase activity" EXACT [EC:1.14.13.22]
synonym: "cyclohexanone:NADPH:oxygen oxidoreductase (6-hydroxylating, 1,2-lactonizing) activity" EXACT [EC:1.14.13.22]
synonym: "cyclohexanone:NADPH:oxygen oxidoreductase (lactone-forming)" EXACT [EC:1.14.13.22]
xref: EC:1.14.13.22
xref: MetaCyc:CYCLOHEXANONE-MONOOXYGENASE-RXN
xref: RHEA:24071
xref: UM-BBD_reactionID:r0166
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018668
name: 3-hydroxybenzoate 4-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxybenzoate + H(+) + NADPH + O(2) = 3,4-dihydroxybenzoate + H(2)O + NADP(+)." [EC:1.14.13.23, RHEA:11483]
synonym: "3-hydroxybenzoate 4-hydroxylase activity" EXACT []
synonym: "3-hydroxybenzoate,NADPH:oxygen oxidoreductase (4-hydroxylating)" EXACT [EC:1.14.13.23]
xref: EC:1.14.13.23
xref: KEGG:R01628
xref: MetaCyc:3-HYDROXYBENZOATE-4-MONOOXYGENASE-RXN
xref: RHEA:11483
xref: UM-BBD_reactionID:r0153
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018669
name: 3-hydroxybenzoate 6-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxybenzoate + H(+) + NADH + O(2) = 2,5-dihydroxybenzoate + H(2)O + NAD(+)." [EC:1.14.13.24, RHEA:22695]
synonym: "3-hydroxybenzoate 6-hydroxylase activity" EXACT []
synonym: "3-hydroxybenzoate,NADH:oxygen oxidoreductase (6-hydroxylating)" EXACT [EC:1.14.13.24]
synonym: "3-hydroxybenzoic acid-6-hydroxylase activity" EXACT [EC:1.14.13.24]
synonym: "m-hydroxybenzoate 6-hydroxylase activity" EXACT [EC:1.14.13.24]
xref: EC:1.14.13.24
xref: KEGG:R02589
xref: MetaCyc:3-HYDROXYBENZOATE-6-MONOOXYGENASE-RXN
xref: RHEA:22695
xref: UM-BBD_reactionID:r0402
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018670
name: 4-aminobenzoate 1-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-aminobenzoate + NADPH + H+ + O2 = 4-hydroxyaniline + NADP+ + H2O + CO2." [EC:1.14.13.27]
synonym: "4-aminobenzoate dehydrogenase activity" EXACT [EC:1.14.13.27]
synonym: "4-aminobenzoate hydroxylase activity" EXACT []
synonym: "4-aminobenzoate monooxygenase activity" EXACT [EC:1.14.13.27]
synonym: "4-aminobenzoate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating, decarboxylating)" EXACT [EC:1.14.13.27]
xref: EC:1.14.13.27
xref: MetaCyc:4-AMINOBENZOATE-1-MONOOXYGENASE-RXN
xref: UM-BBD_reactionID:r0597
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018671
name: 4-hydroxybenzoate 3-monooxygenase [NAD(P)H] activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxybenzoate + NAD(P)H + H+ + O2 = 3,4-dihydroxybenzoate + NAD(P)+ + H2O." [EC:1.14.13.33]
synonym: "4-hydroxybenzoate 3-hydroxylase activity" BROAD [EC:1.14.13.33]
synonym: "4-hydroxybenzoate 3-monooxygenase (reduced nicotinamide adenine dinucleotide (phosphate))" EXACT []
synonym: "4-hydroxybenzoate,NAD(P)H:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.33]
synonym: "4-hydroxybenzoate-3-hydroxylase activity" EXACT [EC:1.14.13.33]
xref: EC:1.14.13.33
xref: MetaCyc:1.14.13.33-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018672
name: anthranilate 3-monooxygenase (deaminating) activity
namespace: molecular_function
def: "Catalysis of the reaction: anthranilate + 2 H(+) + NADPH + O(2) = 2,3-dihydroxybenzoate + NADP(+) + NH(4)(+)." [EC:1.14.13.35, RHEA:21239]
synonym: "anthranilate 2,3-dioxygenase (deaminating)" EXACT [EC:1.14.13.35]
synonym: "anthranilate 2,3-hydroxylase (deaminating) activity" EXACT [EC:1.14.13.35]
synonym: "anthranilate hydroxylase (deaminating) activity" EXACT []
synonym: "anthranilate hydroxylase activity" BROAD [EC:1.14.13.35]
synonym: "anthranilate,NADPH:oxygen oxidoreductase (3-hydroxylating, deaminating)" EXACT [EC:1.14.13.35]
xref: EC:1.14.13.35
xref: KEGG:R00980
xref: MetaCyc:1.14.13.35-RXN
xref: RHEA:21239
xref: UM-BBD_reactionID:r0578
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018673
name: anthraniloyl-CoA monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-aminobenzoyl-CoA + 2 NADPH + 2 H+ + O2 = 2-amino-5-oxocyclohex-1-enecarboxyl-CoA + H2O + 2 NADP+." [EC:1.14.13.40]
subset: gosubset_prok
synonym: "2-aminobenzoyl-CoA monooxygenase/reductase activity" EXACT [EC:1.14.13.40]
synonym: "2-aminobenzoyl-CoA,NAD(P)H:oxygen oxidoreductase (de-aromatizing)" EXACT [EC:1.14.13.40]
synonym: "anthraniloyl coenzyme A reductase activity" EXACT [EC:1.14.13.40]
xref: EC:1.14.13.40
xref: MetaCyc:ANTHRANILOYL-COA-MONOOXYGENASE-RXN
xref: UM-BBD_reactionID:r0568
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018674
name: (S)-limonene 3-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (4S)-limonene + H(+) + NADPH + O(2) = (1S,6R)-isopiperitenol + H(2)O + NADP(+)." [EC:1.14.13.47, RHEA:15132]
synonym: "(-)-limonene 3-hydroxylase activity" EXACT [EC:1.14.13.47]
synonym: "(-)-limonene 3-monooxygenase activity" EXACT []
synonym: "(-)-limonene,NADPH:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.13.47]
synonym: "(S)-limonene,NADPH:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.47]
synonym: "limonene 3-hydroxylase activity" EXACT []
xref: EC:1.14.13.47
xref: KEGG:R02469
xref: MetaCyc:--LIMONENE-3-MONOOXYGENASE-RXN
xref: RHEA:15132
xref: UM-BBD_reactionID:r0739
is_a: GO:0019113 ! limonene monooxygenase activity

[Term]
id: GO:0018675
name: (S)-limonene 6-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (-)-limonene + NADPH + H+ + O2 = (-)-trans-carveol + NADP+ + H2O." [EC:1.14.13.48]
synonym: "(-)-limonene 6-hydroxylase activity" EXACT [EC:1.14.13.48]
synonym: "(-)-limonene 6-monooxygenase activity" EXACT []
synonym: "(-)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating) activity" EXACT [EC:1.14.13.48]
synonym: "(S)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating)" EXACT [EC:1.14.13.48]
synonym: "limonene 6-hydroxylase activity" EXACT []
xref: EC:1.14.13.48
xref: MetaCyc:--LIMONENE-6-MONOOXYGENASE-RXN
xref: RHEA:17948
xref: UM-BBD_reactionID:r0713
is_a: GO:0019113 ! limonene monooxygenase activity

[Term]
id: GO:0018676
name: (S)-limonene 7-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (4S)-limonene + H(+) + NADPH + O(2) = (4S)-perillyl alcohol + H(2)O + NADP(+)." [EC:1.14.13.49, RHEA:23435]
synonym: "(-)-limonene 7-monooxygenase activity" EXACT []
synonym: "(-)-limonene hydroxylase activity" EXACT [EC:1.14.13.49]
synonym: "(-)-limonene monooxygenase activity" EXACT [EC:1.14.13.49]
synonym: "(-)-limonene,NADPH:oxygen oxidoreductase (7-hydroxylating) activity" EXACT [EC:1.14.13.49]
synonym: "(S)-limonene,NADPH:oxygen oxidoreductase (7-hydroxylating)" EXACT [EC:1.14.13.49]
synonym: "limonene hydroxylase activity" EXACT []
xref: EC:1.14.13.49
xref: KEGG:R02470
xref: MetaCyc:--LIMONENE-7-MONOOXYGENASE-RXN
xref: RHEA:23435
xref: UM-BBD_reactionID:r0728
is_a: GO:0019113 ! limonene monooxygenase activity

[Term]
id: GO:0018677
name: pentachlorophenol monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: pentachlorophenol + NADPH + H+ + O2 = tetrachlorohydroquinone + NADP+ + chloride." [EC:1.14.13.50]
subset: gosubset_prok
synonym: "PCB 4-monooxygenase activity" EXACT [EC:1.14.13.50]
synonym: "PCB4MO activity" EXACT [EC:1.14.13.50]
synonym: "PCP hydroxylase activity" EXACT [EC:1.14.13.50]
synonym: "PcpB" RELATED [EC:1.14.13.50]
synonym: "pentachlorophenol 4-monooxygenase activity" EXACT []
synonym: "pentachlorophenol dechlorinase activity" EXACT [EC:1.14.13.50]
synonym: "pentachlorophenol dehalogenase activity" EXACT [EC:1.14.13.50]
synonym: "pentachlorophenol hydroxylase activity" EXACT []
synonym: "pentachlorophenol,NADPH:oxygen oxidoreductase (hydroxylating, dechlorinating)" EXACT [EC:1.14.13.50]
xref: EC:1.14.13.50
xref: MetaCyc:PCP4MONO-RXN
xref: UM-BBD_enzymeID:e0148
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018678
name: 4-hydroxybenzoate 1-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxybenzoate + NADPH + H+ + O2 = hydroquinone + NADP+ + H2O + CO2." [EC:1.14.13.64]
synonym: "4-hydroxybenzoate 1-monooxygenase activity" EXACT []
synonym: "4-hydroxybenzoate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating, decarboxylating)" EXACT [EC:1.14.13.64]
xref: EC:1.14.13.64
xref: MetaCyc:1.14.13.64-RXN
xref: UM-BBD_reactionID:r0752
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018679
name: dibenzothiophene-5,5-dioxide monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: dibenzothiophene-5,5-dioxide + O2 + 2 NADH + H+ = 2 NAD+ + H2O + 2'-hydroxybiphenyl-2-sulfinate." [UM-BBD_reactionID:r0235]
xref: EC:1.14.14.-
xref: MetaCyc:RXN-623
xref: UM-BBD_reactionID:r0235
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0018680
name: deethylatrazine monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 deethylatrazine + O2 = 2 CH3COCH3 + 2 deisopropyldeethylatrazine." [UM-BBD_reactionID:r0128]
xref: EC:1.14.15.-
xref: UM-BBD_reactionID:r0128
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018681
name: deisopropylatrazine monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 deisopropylatrazine + O2 = 2 acetaldehyde + 2 deisopropyldeethylatrazine." [KEGG:R05567]
xref: EC:1.14.15.-
xref: KEGG:R05567
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018682
name: atrazine N-dealkylase activity
namespace: molecular_function
def: "Catalysis of the reaction: atrazine + O2 + 2 H+ = deethylatrazine + acetaldehyde + H2O." [MetaCyc:R461-RXN, UM-BBD_reactionID:r0127]
synonym: "atrazine monooxygenase activity" RELATED [UM-BBD_enzymeID:e0090]
xref: EC:1.14.15.-
xref: MetaCyc:R461-RXN
xref: UM-BBD_reactionID:r0127
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018683
name: camphor 5-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (+)-camphor + putidaredoxin + O2 = (+)-exo-5-hydroxycamphor + oxidized putidaredoxin + H2O." [EC:1.14.15.1]
subset: gosubset_prok
synonym: "(+)-camphor,reduced putidaredoxin:oxygen oxidoreductase (5-hydroxylating)" EXACT [EC:1.14.15.1]
synonym: "2-bornanone 5-exo-hydroxylase activity" EXACT [EC:1.14.15.1]
synonym: "bornanone 5-exo-hydroxylase activity" EXACT [EC:1.14.15.1]
synonym: "camphor 5-exo-hydroxylase activity" EXACT [EC:1.14.15.1]
synonym: "camphor 5-exo-methylene hydroxylase activity" EXACT []
synonym: "camphor 5-exohydroxylase activity" EXACT [EC:1.14.15.1]
synonym: "camphor hydroxylase activity" EXACT [EC:1.14.15.1]
synonym: "camphor methylene hydroxylase activity" EXACT [EC:1.14.15.1]
synonym: "cytochrome p450-cam activity" EXACT [EC:1.14.15.1]
synonym: "d-camphor monooxygenase activity" EXACT [EC:1.14.15.1]
synonym: "D-camphor-exo-hydroxylase activity" EXACT [EC:1.14.15.1]
synonym: "methylene hydroxylase activity" EXACT [EC:1.14.15.1]
synonym: "methylene monooxygenase activity" EXACT [EC:1.14.15.1]
xref: EC:1.14.15.1
xref: MetaCyc:R541-RXN
xref: UM-BBD_enzymeID:e0300
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018684
name: camphor 1,2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (1R)-bornane-2,5-dione + reduced rubredoxin + O2 = 5-oxo-1,2-campholide + oxidized rubredoxin + H2O." [EC:1.14.15.2]
synonym: "(+)-camphor,reduced-rubredoxin:oxygen oxidoreductase (1,2-lactonizing)" EXACT [EC:1.14.15.2]
synonym: "2,5-diketocamphane lactonizing enzyme activity" EXACT [EC:1.14.15.2]
synonym: "camphor ketolactonase I activity" EXACT [EC:1.14.15.2]
synonym: "ketolactonase I" RELATED [EC:1.14.15.2]
synonym: "oxygenase, camphor 1,2-mono" EXACT [EC:1.14.15.2]
xref: EC:1.14.15.2
xref: MetaCyc:CAMPHOR-12-MONOOXYGENASE-RXN
xref: UM-BBD_enzymeID:e0302
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018685
name: alkane 1-monooxygenase activity
namespace: molecular_function
alt_id: GO:0008393
def: "Catalysis of the reaction: octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O." [EC:1.14.15.3]
subset: gosubset_prok
synonym: "1-hydroxylase activity" EXACT [EC:1.14.15.3]
synonym: "alkane 1-hydroxylase activity" EXACT []
synonym: "alkane hydroxylase activity" EXACT [EC:1.14.15.3]
synonym: "alkane monooxygenase activity" EXACT [EC:1.14.15.3]
synonym: "alkane,reduced-rubredoxin:oxygen 1-oxidoreductase activity" EXACT [EC:1.14.15.3]
synonym: "fatty acid (omega-1)-hydroxylase activity" EXACT []
synonym: "fatty acid omega-hydroxylase activity" NARROW [EC:1.14.15.3]
synonym: "lauric acid omega-hydroxylase activity" NARROW [EC:1.14.15.3]
synonym: "omega-hydroxylase activity" RELATED [EC:1.14.15.3]
xref: EC:1.14.15.3
xref: MetaCyc:ALKANE-1-MONOOXYGENASE-RXN
xref: UM-BBD_enzymeID:e0022
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018686
name: 6-hydroxy pseudo-oxynicotine monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 6-hydroxypseudooxynicotine + O2 = 2 2,6-dihydroxypseudooxynicotine." [UM-BBD_reactionID:r0480]
xref: EC:1.14.18.-
xref: UM-BBD_reactionID:r0480
is_a: GO:0016716 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018687
name: biphenyl 2,3-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: biphenyl + NADH + H+ + O2 = (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+. This reaction requires Fe2+." [EC:1.14.12.18]
subset: gosubset_prok
synonym: "biphenyl dioxygenase activity" EXACT [EC:1.14.12.18]
synonym: "biphenyl,NADH:oxygen oxidoreductase (2,3-hydroxylating)" EXACT [EC:1.14.12.18]
xref: EC:1.14.12.18
xref: MetaCyc:1.14.12.18-RXN
xref: RHEA:18168
xref: UM-BBD_enzymeID:e0089
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018688
name: DDT 2,3-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane + O2 + 2 H+ + 2 e- = cis-2,3-dihydrodiol DDT. 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane is also known as DDT." [UM-BBD_reactionID:r0450]
xref: EC:1.14.99.-
xref: UM-BBD_reactionID:r0450
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
is_a: GO:0051213 ! dioxygenase activity

[Term]
id: GO:0018689
name: naphthalene disulfonate 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (1/2)-unsubstituted naphthalenoid-(2/1)-sulfonate + 2 H+ + 2 e- + O2 = 1,2-dihydroxynaphthalene derivative + HSO3(-). Substrates include naphthalene-1,6-disulfonate (forms 1,2-dihydroxynaphthalene-6-sulfonate), naphthalene-1-sulfonate (forms 1,2-dihydroxynaphthalene), naphthalene-2,6-disulfonate (forms 1,2-dihydroxynaphthalene-6-sulfonate) and naphthalene-2-sulfonate (forms 1,2-dihydroxynaphthalene)." [UM-BBD_enzymeID:e0249]
synonym: "naphthalene disulphonate 1,2-dioxygenase activity" EXACT []
xref: EC:1.14.99.-
xref: UM-BBD_enzymeID:e0249
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0018690
name: 4-methoxybenzoate monooxygenase (O-demethylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-methoxybenzoate + AH(2) + O(2) = 4-hydroxybenzoate + A + formaldehyde + H(2)O." [EC:1.14.99.15, RHEA:18616]
synonym: "4-methoxybenzoate 4-monooxygenase (O-demethylating)" EXACT [EC:1.14.99.15]
synonym: "4-methoxybenzoate monooxygenase activity" EXACT []
synonym: "4-methoxybenzoate O-demethylase activity" EXACT [EC:1.14.99.15]
synonym: "4-methoxybenzoate,hydrogen-donor:oxygen oxidoreductase (O-demethylating)" EXACT [EC:1.14.99.15]
synonym: "p-anisic O-demethylase activity" EXACT [EC:1.14.99.15]
synonym: "piperonylate-4-O-demethylase activity" EXACT [EC:1.14.99.15]
xref: EC:1.14.99.15
xref: KEGG:R01306
xref: MetaCyc:1.14.99.15-RXN
xref: RHEA:18616
xref: UM-BBD_reactionID:r0154
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0018693
name: ethylbenzene hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: A + ethylbenzene + H(2)O = (S)-1-phenylethanol + AH(2)." [EC:1.17.99.2, RHEA:17900]
synonym: "ethylbenzene dehydrogenase activity" EXACT [EC:1.17.99.2]
synonym: "ethylbenzene:(acceptor) oxidoreductase activity" EXACT [EC:1.17.99.2]
xref: EC:1.17.99.2
xref: KEGG:R05745
xref: MetaCyc:RXN-1301
xref: RHEA:17900
xref: UM-BBD_reactionID:r0234
is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups

[Term]
id: GO:0018694
name: p-cymene methyl hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: p-cymene + NADH + O2 = NAD+ + OH- + p-cumic alcohol." [UM-BBD_reactionID:r0392]
xref: EC:1.17.99.-
xref: MetaCyc:RXN-661
xref: UM-BBD_reactionID:r0392
is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups

[Term]
id: GO:0018695
name: 4-cresol dehydrogenase (hydroxylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-cresol + acceptor + H2O = 4-hydroxybenzaldehyde + reduced acceptor." [EC:1.17.99.1]
subset: gosubset_prok
synonym: "4-cresol dehydrogenase activity" EXACT []
synonym: "4-cresol:acceptor oxidoreductase (methyl-hydroxylating)" EXACT [EC:1.17.99.1]
synonym: "p-cresol methylhydroxylase activity" EXACT [EC:1.17.99.1]
synonym: "p-cresol-(acceptor) oxidoreductase (hydroxylating) activity" EXACT [EC:1.17.99.1]
xref: EC:1.17.99.1
xref: MetaCyc:1.17.99.1-RXN
xref: RHEA:15144
xref: UM-BBD_reactionID:r0272
is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups

[Term]
id: GO:0018697
name: carbonyl sulfide nitrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: carbonyl sulfide + 2 H+ + 2 e- = hydrogen sulfide + carbon monoxide." [UM-BBD_reactionID:r0600]
synonym: "carbonyl sulphide nitrogenase activity" EXACT []
xref: EC:1.18.6.1
xref: UM-BBD_reactionID:r0600
is_a: GO:0016732 ! oxidoreductase activity, acting on iron-sulfur proteins as donors, dinitrogen as acceptor

[Term]
id: GO:0018698
name: vinyl chloride reductive dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: vinyl chloride + 2 H+ + 2 e- = HCl + ethene." [UM-BBD_reactionID:r0352]
xref: EC:1.97.1.-
xref: MetaCyc:VCREDCHLOR-RXN
xref: UM-BBD_reactionID:r0352
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0018699
name: 1,1,1-trichloroethane reductive dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,1,1-trichloroethane + 2 H+ + 2 e- = 1,1-dichloroethane + HCl." [UM-BBD_reactionID:r1007]
xref: EC:1.97.1.-
xref: UM-BBD_reactionID:r1007
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0018700
name: 2-chloro-N-isopropylacetanilide reductive dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-chloro-N-isopropylacetanilide + H+ + 2 e- = Cl- + N-isopropylacetanilide." [UM-BBD_reactionID:r0719]
xref: EC:1.97.1.-
xref: UM-BBD_reactionID:r0719
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0018701
name: 2,5-dichlorohydroquinone reductive dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: organohalide + 2 H+ + 2 e- = R-H + HCl. Reactants include chlorohydroquinone (forms hydroquinone) and 2,5-dichlorohydroquinone (forms chlorohydroquinone)." [UM-BBD_enzymeID:e0366]
xref: EC:1.97.1.-
xref: UM-BBD_enzymeID:e0366
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0018702
name: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene + H+ + 2 e- = Cl- + 1-chloro-2,2-bis(4-chlorophenyl)ethene. 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene is also known as DDE; 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU." [UM-BBD_reactionID:r0440]
synonym: "1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene dehalogenase activity" EXACT []
synonym: "DDE dehalogenase activity" EXACT []
xref: EC:1.97.1.-
xref: UM-BBD_reactionID:r0440
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0018703
name: 2,4-dichlorophenoxyacetate dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4-dichlorophenoxyacetic acid + H+ + 2 e- = Cl- + 4-chlorophenoxyacetate." [UM-BBD_reactionID:r0280]
xref: UM-BBD_reactionID:r0280
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0018704
name: obsolete 5-chloro-2-hydroxymuconic semialdehyde dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-chloro-2-hydroxymuconic semialdehyde + H+ + 2 e- = Cl- + 2-hydroxymuconic semialdehyde." [UM-BBD_enzymeID:e0237]
comment: This term was made obsolete because it was derived from a UM-BBD enzyme entry that has been deleted, and no other information can be found to suggest that it is a naturally occurring activity.
synonym: "5-chloro-2-hydroxymuconic semialdehyde dehalogenase activity" EXACT []
xref: EC:1.97.1.-
xref: UM-BBD_enzymeID:e0237
is_obsolete: true

[Term]
id: GO:0018705
name: 1,2-dichloroethene reductive dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-dichloroethene + 2 H+ + 2 e- = HCl + vinyl chloride." [UM-BBD_enzymeID:e0272]
synonym: "1,2-dichloroethylene reductive dehalogenase activity" EXACT []
xref: UM-BBD_enzymeID:e0272
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0018706
name: pyrogallol hydroxytransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2,3,5-tetrahydroxybenzene + 1,2,3-trihydroxybenzene = 1,3,5-trihydroxybenzene + 1,2,3,5-tetrahydroxybenzene." [EC:1.97.1.2]
subset: gosubset_prok
synonym: "1,2,3,5-tetrahydroxybenzene hydroxyltransferase activity" EXACT [EC:1.97.1.2]
synonym: "1,2,3,5-tetrahydroxybenzene-pyrogallol hydroxyltransferase (transhydroxylase)" EXACT [EC:1.97.1.2]
synonym: "1,2,3,5-tetrahydroxybenzene:1,2,3-trihydroxybenzene hydroxyltransferase activity" EXACT [EC:1.97.1.2]
synonym: "1,2,3,5-tetrahydroxybenzene:1,2,3-trihydroxybenzene hydroxytransferase activity" EXACT [EC:1.97.1.2]
synonym: "1,2,3,5-tetrahydroxybenzene:pyrogallol transhydroxylase activity" EXACT [EC:1.97.1.2]
synonym: "pyrogallol hydroxyltransferase activity" EXACT []
synonym: "transhydroxylase activity" RELATED [EC:1.97.1.2]
xref: EC:1.97.1.2
xref: MetaCyc:1.97.1.2-RXN
xref: UM-BBD_reactionID:r0006
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0018707
name: 1-phenanthrol methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-phenanthrol + X-CH3 = X + 1-methoxyphenanthrene." [UM-BBD_reactionID:r0493]
xref: EC:2.1.1.-
xref: UM-BBD_reactionID:r0493
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0018708
name: thiol S-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + a thiol = S-adenosyl-L-homocysteine + a thioether." [EC:2.1.1.9]
synonym: "S-adenosyl-L-methionine:thiol S-methyltransferase activity" EXACT [EC:2.1.1.9]
synonym: "thiol methyltransferase activity" EXACT [EC:2.1.1.9]
synonym: "TMT" RELATED [EC:2.1.1.9]
xref: EC:2.1.1.9
xref: MetaCyc:THIOL-S-METHYLTRANSFERASE-RXN
xref: Reactome:REACT_6752 "2-mercaptoethanol can be S-methylated, Homo sapiens"
xref: UM-BBD_enzymeID:e0146
is_a: GO:0008172 ! S-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0018710
name: acetone carboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetone + ATP + CO(2) + 2 H(2)O = acetoacetate + AMP + 4 H(+) + 2 phosphate." [EC:6.4.1.6, RHEA:18388]
synonym: "acetone:carbon-dioxide ligase (AMP-forming)" EXACT [EC:6.4.1.6]
xref: EC:6.4.1.6
xref: KEGG:R05735
xref: MetaCyc:6.4.1.6-RXN
xref: RHEA:18388
is_a: GO:0016885 ! ligase activity, forming carbon-carbon bonds

[Term]
id: GO:0018711
name: benzoyl acetate-CoA thiolase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzoyl acetyl-CoA + CoA = acetyl-CoA + benzoyl-CoA." [UM-BBD_reactionID:r0243]
xref: EC:2.3.1.-
xref: MetaCyc:RXN-1305
xref: UM-BBD_reactionID:r0243
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0018712
name: 3-hydroxybutyryl-CoA thiolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxy-5-oxohexanoyl-CoA + CoASH = 3-hydroxybutyryl-CoA + acetyl-CoA." [UM-BBD_reactionID:r0010]
xref: EC:2.3.1.-
xref: MetaCyc:R7-RXN
xref: UM-BBD_reactionID:r0010
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0018713
name: 3-ketopimelyl-CoA thiolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-ketopimeloyl-CoA + CoA = glutaryl-CoA + acetyl-CoA." [UM-BBD_reactionID:r0197]
xref: EC:2.3.1.-
xref: MetaCyc:RXN-8032
xref: UM-BBD_reactionID:r0197
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0018715
name: 9-phenanthrol UDP-glucuronosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 9-phenanthrol + UDP-glucuronate = 9-phenanthryl-beta-D-glucuronide + UDP." [UM-BBD_reactionID:r0567]
xref: EC:2.4.1.-
xref: UM-BBD_reactionID:r0567
is_a: GO:0015020 ! glucuronosyltransferase activity

[Term]
id: GO:0018716
name: 1-phenanthrol glycosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-phenanthrol + glucose = 1-phenanthryl-beta-D-glucopyranoside + H2O." [UM-BBD_reactionID:r0525]
xref: EC:2.4.1.-
xref: UM-BBD_reactionID:r0525
is_a: GO:0019112 ! phenanthrol glycosyltransferase activity

[Term]
id: GO:0018717
name: 9-phenanthrol glycosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 9-phenanthrol + glucose = 9-phenanthryl-beta-D-glucopyranoside + H2O." [UM-BBD_reactionID:r0511]
xref: EC:2.4.1.-
xref: UM-BBD_reactionID:r0511
is_a: GO:0019112 ! phenanthrol glycosyltransferase activity

[Term]
id: GO:0018718
name: 1,2-dihydroxy-phenanthrene glycosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-dihydroxyphenanthrene + UDP-glucose = 2-hydroxy-1-phenanthryl-beta-D-glucopyranoside + UDP." [UM-BBD_reactionID:r0569]
xref: EC:2.4.1.-
xref: UM-BBD_reactionID:r0569
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0018719
name: 6-aminohexanoate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-aminohexanoate + alpha-ketoglutarate = glutamate + 6-oxohexanoate." [UM-BBD_reactionID:r0449]
xref: EC:2.6.1.-
xref: MetaCyc:R562-RXN
xref: UM-BBD_reactionID:r0449
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0018720
name: phenol kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenol + X-HPO3- = XH + phenylphosphate." [UM-BBD_reactionID:r0155]
xref: EC:2.7.1.-
xref: MetaCyc:PHENOLPHOS-RXN
xref: UM-BBD_reactionID:r0155
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0018721
name: trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-9R,10R-dihydrodiolphenanthrene + 2 X-SO3(-) = 2 HX + phenanthrene-9,10-dihydrodiolsulfate conjugate." [UM-BBD_reactionID:r0559]
synonym: "trans-9R,10R-dihydrodiolphenanthrene sulphotransferase activity" EXACT []
xref: EC:2.8.2.-
xref: UM-BBD_reactionID:r0559
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0018722
name: 1-phenanthrol sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-phenanthrol + X-SO3(-) = HX + 1-phenanthrylsulfate." [UM-BBD_reactionID:r0565]
synonym: "1-phenanthrol sulphotransferase activity" EXACT []
xref: EC:2.8.2.-
xref: UM-BBD_reactionID:r0565
is_a: GO:0019111 ! phenanthrol sulfotransferase activity

[Term]
id: GO:0018723
name: 3-phenanthrol sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-phenanthrol + X-SO3(-) = HX + 3-phenanthrylsulfate." [UM-BBD_reactionID:r0561]
synonym: "3-phenanthrol sulphotransferase activity" EXACT []
xref: EC:2.8.2.-
xref: UM-BBD_reactionID:r0561
is_a: GO:0019111 ! phenanthrol sulfotransferase activity

[Term]
id: GO:0018724
name: 4-phenanthrol sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-phenanthrol + X-SO3(-) = HX + 4-phenanthrylsulfate." [UM-BBD_reactionID:r0562]
synonym: "4-phenanthrol sulphotransferase activity" EXACT []
xref: EC:2.8.2.-
xref: UM-BBD_reactionID:r0562
is_a: GO:0019111 ! phenanthrol sulfotransferase activity

[Term]
id: GO:0018725
name: trans-3,4-dihydrodiolphenanthrene sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-3,4-dihydrodiolphenanthrene + 2 X-SO3(-) = 2 HX + phenanthrene-3,4-dihydrodiolsulfate conjugate." [UM-BBD_reactionID:r0558]
synonym: "trans-3,4-dihydrodiolphenanthrene sulphotransferase activity" EXACT []
xref: EC:2.8.2.-
xref: UM-BBD_reactionID:r0558
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0018726
name: 9-phenanthrol sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 9-phenanthrol + X-SO3(-) = HX + 9-phenanthrylsulfate." [UM-BBD_reactionID:r0564]
synonym: "9-phenanthrol sulphotransferase activity" EXACT []
xref: EC:2.8.2.-
xref: UM-BBD_reactionID:r0564
is_a: GO:0019111 ! phenanthrol sulfotransferase activity

[Term]
id: GO:0018727
name: 2-phenanthrol sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-phenanthrol + X-SO3(-) = HX + 2-phenanthrylsulfate." [UM-BBD_reactionID:r0563]
synonym: "2-phenanthrol sulphotransferase activity" EXACT []
xref: EC:2.8.2.-
xref: UM-BBD_reactionID:r0563
is_a: GO:0019111 ! phenanthrol sulfotransferase activity

[Term]
id: GO:0018729
name: propionate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + propanoate = acetate + propanoyl-CoA." [EC:2.8.3.1]
subset: gosubset_prok
synonym: "acetyl-CoA:propanoate CoA-transferase activity" EXACT [EC:2.8.3.1]
synonym: "propionate coenzyme A-transferase activity" EXACT [EC:2.8.3.1]
synonym: "propionate-CoA:lactoyl-CoA transferase activity" EXACT [EC:2.8.3.1]
synonym: "propionyl CoA:acetate CoA transferase activity" EXACT [EC:2.8.3.1]
synonym: "propionyl-CoA transferase activity" EXACT [EC:2.8.3.1]
xref: EC:2.8.3.1
xref: MetaCyc:PROPIONATE-COA-TRANSFERASE-RXN
xref: RHEA:23523
xref: UM-BBD_reactionID:r0087
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0018730
name: glutaconate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + (E)-glutaconate = acetate + glutaconyl-1-CoA." [EC:2.8.3.12]
subset: gosubset_prok
synonym: "acetyl-CoA:(E)-glutaconate CoA-transferase activity" EXACT [EC:2.8.3.12]
xref: EC:2.8.3.12
xref: MetaCyc:GLUTACONATE-COA-TRANSFERASE-RXN
xref: RHEA:23211
xref: UM-BBD_reactionID:r0085
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0018731
name: 1-oxa-2-oxocycloheptane lactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-oxa-2-oxocycloheptane + H2O = 6-hydroxyhexanoate." [UM-BBD_reactionID:r0167]
xref: EC:3.1.1.-
xref: UM-BBD_reactionID:r0167
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0018732
name: sulfolactone hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-sulfolactone + OH- = HSO3(-) + maleylacetate." [UM-BBD_reactionID:r0583]
synonym: "sulpholactone hydrolase activity" EXACT []
xref: EC:3.1.1.-
xref: UM-BBD_reactionID:r0583
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0018733
name: 3,4-dihydrocoumarin hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,4-dihydrocoumarin + H2O = 3-(2-hydroxyphenyl) propionate." [UM-BBD_reactionID:r0419]
xref: EC:3.1.1.-
xref: UM-BBD_reactionID:r0419
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0018734
name: butyrolactone hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: butyrolactone + H2O = 4-hydroxybutanoate." [UM-BBD_reactionID:r0016]
xref: EC:3.1.1.-
xref: UM-BBD_reactionID:r0016
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0018736
name: 6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA + H2O = 3-hydroxypimeloyl-CoA." [UM-BBD_reactionID:r0206]
xref: EC:3.7.1.-
xref: UM-BBD_reactionID:r0206
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0018737
name: 2-ketocyclohexane-1-carboxyl-CoA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-ketocyclohexane-1-carboxyl-CoA + H2O = pimeloyl-CoA." [UM-BBD_reactionID:r0193]
xref: EC:3.7.1.-
xref: UM-BBD_reactionID:r0193
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0018738
name: S-formylglutathione hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-formylglutathione + H(2)O = formate + glutathione + H(+)." [EC:3.1.2.12, RHEA:14964]
subset: goslim_chembl
subset: gosubset_prok
xref: EC:3.1.2.12
xref: KEGG:R00527
xref: MetaCyc:S-FORMYLGLUTATHIONE-HYDROLASE-RXN
xref: RHEA:14964
xref: UM-BBD_reactionID:r0241
is_a: GO:0016790 ! thiolester hydrolase activity

[Term]
id: GO:0018739
name: 4-hydroxybenzoyl-CoA thioesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxybenzoyl-CoA + H(2)O = 4-hydroxybenzoate + CoA + H(+)." [EC:3.1.2.23, RHEA:11951]
subset: gosubset_prok
synonym: "4-hydroxybenzoyl-CoA hydrolase activity" EXACT [EC:3.1.2.23]
synonym: "4-hydroxybenzoyl-CoA thiolesterase activity" EXACT []
xref: EC:3.1.2.23
xref: KEGG:R01301
xref: MetaCyc:3.1.2.23-RXN
xref: RHEA:11951
xref: UM-BBD_reactionID:r0141
is_a: GO:0016289 ! CoA hydrolase activity

[Term]
id: GO:0018740
name: 2'-hydroxybiphenyl-2-sulfinate desulfinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2'-hydroxybiphenyl-2-sulfinate + H(2)O = biphenyl-2-ol + sulfite." [EC:3.13.1.3, RHEA:12948]
subset: gosubset_prok
synonym: "2'-hydroxybiphenyl-2-sulfinate sulfinolyase activity" EXACT []
synonym: "2'-hydroxybiphenyl-2-sulfinate sulfohydrolase activity" EXACT [EC:3.13.1.3]
synonym: "2-(2'-hydroxyphenyl)benzenesulfinate desulfinase activity" EXACT [EC:3.13.1.3]
synonym: "2-(2-hydroxyphenyl) benzenesulfinate sulfohydrolase activity" EXACT [EC:3.13.1.3]
synonym: "2-(2-hydroxyphenyl) benzenesulfinate:H2O hydrolase activity" EXACT [EC:3.13.1.3]
synonym: "2-(2-hydroxyphenyl)benzenesulfinate desulfinase activity" EXACT [EC:3.13.1.3]
synonym: "2-(2-hydroxyphenyl)benzenesulfinate hydrolase activity" EXACT [EC:3.13.1.3]
synonym: "2-(2-hydroxyphenyl)benzenesulphinate hydrolase activity" EXACT []
synonym: "dibenzothiophene desulfurization enzyme B" RELATED [EC:3.13.1.3]
synonym: "DszB" RELATED [EC:3.13.1.3]
synonym: "gene dszB-encoded hydrolase activity" EXACT [EC:3.13.1.3]
synonym: "HBPSi desulfinase activity" EXACT [EC:3.13.1.3]
synonym: "HPBS desulfinase activity" EXACT [EC:3.13.1.3]
xref: EC:3.13.1.3
xref: KEGG:R07311
xref: MetaCyc:RXN-624
xref: RHEA:12948
xref: UM-BBD_enzymeID:e0216
is_a: GO:0046508 ! hydrolase activity, acting on carbon-sulfur bonds

[Term]
id: GO:0018741
name: alkyl sulfatase activity
namespace: molecular_function
def: "Catalysis of the reaction: dodecyl sulfate + H2O = sulfate + H+ + 1-dodecanol." [UM-BBD_reactionID:r0602]
synonym: "alkyl sulphatase activity" EXACT []
xref: EC:3.1.6.-
xref: UM-BBD_reactionID:r0602
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0018742
name: epoxide hydrolase B activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the ether in chloro- or hydroxyepoxypropane to produce chloropropane diol or glycerol. Acts on R enantiomers." [UM-BBD_enzymeID:e0051]
xref: EC:3.3.2.-
xref: UM-BBD_enzymeID:e0051
is_a: GO:0004301 ! epoxide hydrolase activity

[Term]
id: GO:0018743
name: phenanthrene-9,10-epoxide hydrolase (9R,10R-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9R,10R-dihydrodiolphenanthrene." [UM-BBD_reactionID:r0560]
xref: EC:3.3.2.-
xref: UM-BBD_reactionID:r0560
is_a: GO:0019119 ! phenanthrene-9,10-epoxide hydrolase activity

[Term]
id: GO:0018744
name: limonene-1,2-epoxide hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: limonene-1,2-epoxide + H2O = limonene-1,2-diol. Other substrates include alicyclic and 1-methyl-substituted epoxides, such as 1-methylcyclohexene oxide, indene oxide and cyclohexene oxide." [EC:3.3.2.8]
subset: gosubset_prok
synonym: "limonene oxide hydrolase activity" EXACT [EC:3.3.2.8]
xref: EC:3.3.2.8
xref: MetaCyc:3.3.2.8-RXN
xref: RHEA:10703
xref: UM-BBD_reactionID:r0734
is_a: GO:0004301 ! epoxide hydrolase activity

[Term]
id: GO:0018745
name: epoxide hydrolase A activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the ether in chloro-, bromo- or hydroxyepoxypropane to produce a chloro- or bromopropane diol or glycerol." [UM-BBD_enzymeID:e0049]
xref: EC:3.3.2.-
xref: UM-BBD_enzymeID:e0049
is_a: GO:0004301 ! epoxide hydrolase activity

[Term]
id: GO:0018746
name: phenanthrene-3,4-epoxide hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenanthrene-3,4-oxide + H2O = trans-3,4-dihydrodiolphenanthrene." [UM-BBD_reactionID:r0535]
xref: EC:3.3.2.-
xref: UM-BBD_reactionID:r0535
is_a: GO:0019118 ! phenanthrene-epoxide hydrolase activity

[Term]
id: GO:0018747
name: phenanthrene-1,2-epoxide hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenanthrene-1,2-oxide + H2O = trans-1,2-dihydrodiolphenanthrene." [UM-BBD_reactionID:r0536]
xref: EC:3.3.2.-
xref: UM-BBD_reactionID:r0536
is_a: GO:0019118 ! phenanthrene-epoxide hydrolase activity

[Term]
id: GO:0018748
name: iprodione amidohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: iprodione + OH- = 3,5-dichlorophenylcarboximide + N-isopropylcarbamate." [UM-BBD_reactionID:r0706]
xref: EC:3.5.1.-
xref: UM-BBD_reactionID:r0706
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0018749
name: (3,5-dichlorophenylurea)acetate amidohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3,5-dichlorophenylurea)acetate + OH- = 3,5-dichloroaniline + N-carboxyglycine." [UM-BBD_reactionID:r0708]
xref: EC:3.5.1.-
xref: UM-BBD_reactionID:r0708
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0018750
name: biuret amidohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: biuret + H2O = urea + CO2 + NH3." [EC:3.5.1.84]
xref: EC:3.5.1.84
xref: RHEA:17528
xref: UM-BBD_reactionID:r0846
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0018751
name: 3,5-dichlorophenylcarboximide hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,5-dichlorophenylcarboximide + OH- = (3,5-dichlorophenylurea)acetate." [UM-BBD_reactionID:r0707]
xref: EC:3.5.2.-
xref: UM-BBD_reactionID:r0707
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0018752
name: epsilon-caprolactam lactamase activity
namespace: molecular_function
def: "Catalysis of the reaction: epsilon-caprolactam + H2O = H+ + 6-aminohexanoate." [UM-BBD_reactionID:r0448]
xref: EC:3.5.2.-
xref: MetaCyc:R561-RXN
xref: UM-BBD_reactionID:r0448
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0018753
name: cyanuric acid amidohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyanuric acid + H2O = biuret + CO2." [EC:3.5.2.15]
subset: gosubset_prok
xref: EC:3.5.2.15
xref: MetaCyc:R468-RXN
xref: RHEA:14644
xref: UM-BBD_reactionID:r0116
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0018754
name: ammelide aminohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: ammelide + H2O = cyanuric acid + NH3." [PMID:1991731]
xref: EC:3.5.3.-
xref: MetaCyc:RXN-8017
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0018755
name: 2-chloro-4-hydroxy-6-amino-1,3,5-triazine aminohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-chloro-4-hydroxy-6-amino-1,3,5-triazine + OH- = 2,4-dihydroxy-6-amino-1,3,5-triazine + Cl-." [UM-BBD_reactionID:r1414]
xref: EC:3.5.3.-
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0018756
name: ammeline aminohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: ammeline + H2O = ammelide + NH3." [PMID:1991731]
xref: EC:3.5.3.-
xref: MetaCyc:RXN-8016
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0018757
name: deisopropylhydroxyatrazine aminohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: deisopropylhydroxyatrazine + H2O = NH3 + 2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine." [UM-BBD_reactionID:r0121]
xref: EC:3.5.3.-
xref: UM-BBD_reactionID:r0121
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0018758
name: 2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine aminohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine + H2O = CH3CH2NH2 + cyanuric acid." [UM-BBD_reactionID:r0122]
xref: EC:3.5.3.-
xref: UM-BBD_reactionID:r0122
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0018759
name: methenyltetrahydromethanopterin cyclohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H(2)O = N(5)-formyl-5,6,7,8-tetrahydromethanopterin + H(+)." [EC:3.5.4.27, RHEA:19056]
subset: gosubset_prok
synonym: "5,10-methenyltetrahydromethanopterin 10-hydrolase (decyclizing)" EXACT [EC:3.5.4.27]
synonym: "5,10-methenyltetrahydromethanopterin cyclohydrolase activity" EXACT [EC:3.5.4.27]
synonym: "methenyl-H(4)MPT cyclohydrolase activity" EXACT [EC:3.5.4.27]
synonym: "methenyl-H4MPT cyclohydrolase activity" EXACT [EC:3.5.4.27]
synonym: "N5,N10-methenyltetrahydromethanopterin cyclohydrolase activity" EXACT [EC:3.5.4.27]
xref: EC:3.5.4.27
xref: KEGG:R03464
xref: MetaCyc:3.5.4.27-RXN
xref: RHEA:19056
xref: UM-BBD_reactionID:r0347
is_a: GO:0019238 ! cyclohydrolase activity

[Term]
id: GO:0018760
name: thiocyanate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + 2 H(+) + thiocyanate = carbonyl sulfide + NH(4)(+)." [EC:3.5.5.8, RHEA:21467]
synonym: "thiocyanate aminohydrolase activity" EXACT [EC:3.5.5.8]
xref: EC:3.5.5.8
xref: KEGG:R05780
xref: MetaCyc:RXN-1761
xref: RHEA:21467
xref: UM-BBD_reactionID:r0598
is_a: GO:0016815 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles

[Term]
id: GO:0018761
name: bromoxynil nitrilase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,5-dibromo-4-hydroxybenzonitrile + 2 H(2)O = 3,5-dibromo-4-hydroxybenzoate + NH(4)(+). Involved in the bacterial degradation of the herbicide bromoxynil." [EC:3.5.5.6, RHEA:22103]
subset: gosubset_prok
synonym: "3,5-dibromo-4-hydroxybenzonitrile aminohydrolase activity" EXACT []
synonym: "bromoxynil-specific nitrilase activity" EXACT []
xref: EC:3.5.5.6
xref: KEGG:R04349
xref: MetaCyc:3.5.5.6-RXN
xref: RHEA:22103
xref: UM-BBD_enzymeID:e0357
is_a: GO:0000257 ! nitrilase activity

[Term]
id: GO:0018762
name: aliphatic nitrilase activity
namespace: molecular_function
def: "Catalysis of the reaction: R-CN + H2O = R-COOH + NH3." [EC:3.5.5.7]
subset: gosubset_prok
synonym: "aliphatic nitrile aminohydrolase activity" EXACT [EC:3.5.5.7]
xref: EC:3.5.5.7
xref: MetaCyc:3.5.5.7-RXN
xref: UM-BBD_reactionID:r0622
is_a: GO:0000257 ! nitrilase activity

[Term]
id: GO:0018763
name: hydroxydechloroatrazine ethylaminohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine + H2O = N-isopropylammelide + ethylamine." [EC:3.5.99.3]
subset: gosubset_prok
synonym: "4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine ethylaminohydrolase activity" EXACT [EC:3.5.99.3]
synonym: "AtzB" RELATED [EC:3.5.99.3]
synonym: "hydroxyatrazine ethylaminohydrolase activity" EXACT []
synonym: "hydroxyatrazine hydrolase activity" EXACT [EC:3.5.99.3]
xref: EC:3.5.99.3
xref: MetaCyc:R122-RXN
xref: RHEA:23095
xref: UM-BBD_enzymeID:e0085
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

[Term]
id: GO:0018764
name: N-isopropylammelide isopropylaminohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-isopropylammelide + H2O = cyanuric acid + isopropylamine." [EC:3.5.99.4]
subset: gosubset_prok
synonym: "AtzC" RELATED [EC:3.5.99.4]
xref: EC:3.5.99.4
xref: MetaCyc:R123-RXN
xref: RHEA:23611
xref: UM-BBD_enzymeID:e0086
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

[Term]
id: GO:0018765
name: 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis,cis-2-hydroxy-6-oxohept-2,4-dienoate + OH- = cis-2-hydroxypenta-2,4-dienoate + acetate." [UM-BBD_reactionID:r0263]
xref: EC:3.7.1.-
xref: MetaCyc:2-OH-6-OXOHEPTA-2-4-DIENOATE-HYDR-RXN
xref: UM-BBD_reactionID:r0263
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0018766
name: dihydrophloroglucinol hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: dihydrophloroglucinol + OH- = 3-hydroxy-5-oxohexanoate." [UM-BBD_reactionID:r0008]
xref: EC:3.7.1.-
xref: MetaCyc:R6-RXN
xref: UM-BBD_reactionID:r0008
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0018767
name: 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate + H2O = cis-2-hydroxypenta-2,4-dienoate + isobutyrate." [UM-BBD_reactionID:r0399]
xref: EC:3.7.1.-
xref: UM-BBD_reactionID:r0399
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0018768
name: 2-hydroxy-6-oxo-6-(2'-aminophenyl)hexa-2,4-dienoate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxy-6-oxo-(2'-aminophenyl)-hexa-2,4-dienoate + H2O = 2-aminobenzoate + cis-2-hydroxypenta-2,4-dienoate." [UM-BBD_reactionID:r0458]
xref: EC:3.7.1.-
xref: UM-BBD_reactionID:r0458
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0018769
name: 2-hydroxy-6-oxoocta-2,4-dienoate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxy-6-oxoocta-2,4-dienoate + H2O = H+ + propanoate + cis-2-hydroxypenta-2,4-dienoate." [UM-BBD_reactionID:r0311]
xref: EC:3.7.1.-
xref: UM-BBD_reactionID:r0311
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0018770
name: 6-oxo-2-hydroxy-7-(4'-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7-trienoate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-oxo-2-hydroxy-7-(4'-chlorophenyl)-3,8,8-trichloroocta-2Z,4Z,7-trienoate + H2O = 2-(4'-chlorophenyl)-3,3-dichloropropenoate + cis-2-Hydroxy-3-chloropenta-2,4-dienone + H+." [UM-BBD_reactionID:r0444]
xref: EC:3.7.1.-
xref: UM-BBD_reactionID:r0444
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0018771
name: 2-hydroxy-6-oxonona-2,4-dienedioate hydrolase activity
namespace: molecular_function
alt_id: GO:0008680
def: "Catalysis of the reaction: (2E,4Z)-2-hydroxy-6-oxonona-2,4-dienedioate + H2O = (2E)-2-hydroxypenta-2,4-dienoate + H+ + succinate." [RHEA:24792]
synonym: "(2E,4Z)-2-hydroxy-6-oxona-2,4-dienedioate succinylhydrolase activity" EXACT systematic_synonym [EC:3.7.1.14]
synonym: "2-hydroxy-6-ketonona-2,4-dienedoic acid hydrolase activity" EXACT [UM-BBD_reactionID:r0438]
xref: EC:3.7.1.14
xref: MetaCyc:MHPCHYDROL-RXN
xref: RHEA:24792
xref: UM-BBD_reactionID:r0438
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0018772
name: trioxoheptanoate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4,6-trioxoheptanoate + H2O = acetylpyruvate + acetate." [MetaCyc:R306-RXN, UM-BBD_reactionID:r0094]
xref: EC:3.7.1.-
xref: MetaCyc:R306-RXN
xref: UM-BBD_reactionID:r0094
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0018773
name: acetylpyruvate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetylpyruvate + H(2)O = acetate + H(+) + pyruvate." [EC:3.7.1.6, RHEA:16100]
synonym: "2,4-dioxopentanoate acetylhydrolase activity" EXACT [EC:3.7.1.6]
xref: EC:3.7.1.6
xref: KEGG:R00324
xref: MetaCyc:ACETYLPYRUVATE-HYDROLASE-RXN
xref: RHEA:16100
xref: UM-BBD_reactionID:r0095
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0018774
name: 2,6-dioxo-6-phenylhexa-3-enoate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,6-dioxo-6-phenylhexa-3-enoate + H2O = benzoate + 2-oxopent-4-enoate." [EC:3.7.1.8]
subset: gosubset_prok
synonym: "2,6-dioxo-6-phenylhexa-3-enoate benzoylhydrolase activity" EXACT [EC:3.7.1.8]
synonym: "2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase activity" EXACT []
synonym: "HOHPDA hydrolase activity" EXACT [EC:3.7.1.8]
xref: EC:3.7.1.8
xref: MetaCyc:3.7.1.8-RXN
xref: RHEA:17164
xref: UM-BBD_enzymeID:e0033
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0018775
name: 2-hydroxymuconate-semialdehyde hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxymuconate semialdehyde + H2O = formate + 2-oxopent-4-enoate." [EC:3.7.1.9]
synonym: "2-hydroxymuconate-semialdehyde formylhydrolase activity" EXACT [EC:3.7.1.9]
synonym: "2-hydroxymuconic semialdehyde hydrolase activity" EXACT [EC:3.7.1.9]
synonym: "HMSH" RELATED [EC:3.7.1.9]
synonym: "HOD hydrolase activity" EXACT [EC:3.7.1.9]
xref: EC:3.7.1.9
xref: MetaCyc:3.7.1.9-RXN
xref: RHEA:14552
xref: UM-BBD_enzymeID:e0139
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0018776
name: trans-chloroacrylic acid dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-3-chloroacrylic acid + H2O = H+ + malonate semialdehyde." [UM-BBD_reactionID:r0689]
xref: EC:3.8.1.-
xref: UM-BBD_reactionID:r0689
is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds

[Term]
id: GO:0018777
name: 1,3,4,6-tetrachloro-1,4-cyclohexadiene halidohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: alkyl halide + H2O = alcohol + HCl. Substrates are 1,3(R),4,6(R)-tetrachloro-1,4-cyclohexadiene (forms 2,4,5-trichloro-2,5-cyclohexadiene-1-ol) and 2,4,5-trichloro-2,5-cyclohexadiene-1-ol (forms 2,5-dichloro-2,5-cyclohexadiene-1,4-diol)." [PMID:10464214]
xref: EC:3.8.1.-
is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds

[Term]
id: GO:0018778
name: DL-2 haloacid dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: trichloroacetate + 2 H2O = 3 H+ + 3 Cl- + oxalate." [UM-BBD_reactionID:r0382]
xref: EC:3.8.1.-
xref: MetaCyc:RXN-9150
xref: UM-BBD_reactionID:r0382
is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds

[Term]
id: GO:0018779
name: obsolete 2-chloro-4,6-dihydroxy-1,3,5-triazine hydrolase activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it was derived from a UM-BBD enzyme entry that has been deleted, and no other information can be found to suggest that it is a naturally occurring activity.
synonym: "2-chloro-4,6-dihydroxy-1,3,5-triazine hydrolase activity" EXACT []
xref: EC:3.8.1.-
xref: UM-BBD_enzymeID:e0100
is_obsolete: true

[Term]
id: GO:0018780
name: dichloroacetate halidohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: dichloroacetate + H2O = 2 HCl + glyoxylate." [UM-BBD_reactionID:r0383]
xref: EC:3.8.1.-
xref: UM-BBD_reactionID:r0383
is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds

[Term]
id: GO:0018781
name: S-triazine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-halo or 1-pseudohalo-S-triazine = 1-hydroxy-S-triazine." [UM-BBD_ruleID:bt0330]
xref: EC:3.8.1.-
xref: UM-BBD_enzymeID:e0091
is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds

[Term]
id: GO:0018782
name: cis-chloroacrylic acid dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-3-chloroacrylic acid + H2O = H+ + HCl + malonate semialdehyde." [UM-BBD_reactionID:r0688]
xref: EC:3.8.1.-
xref: UM-BBD_reactionID:r0688
is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds

[Term]
id: GO:0018783
name: deisopropyldeethylatrazine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: deisopropyldeethylatrazine + H2O = 2-chloro-4-hydroxy-6-amino-1,3,5-triazine + NH3." [UM-BBD_reactionID:0129]
xref: EC:3.8.1.-
is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds

[Term]
id: GO:0018784
name: (S)-2-haloacid dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-2-haloacid + H2O = (R)-2-hydroxyacid + halide." [EC:3.8.1.2]
subset: gosubset_prok
synonym: "(S)-2-haloacid halidohydrolase activity" EXACT [EC:3.8.1.2]
synonym: "2-haloacid dehalogenase activity" EXACT []
synonym: "2-haloacid halidohydrolase activity" EXACT [EC:3.8.1.2]
synonym: "2-haloalkanoic acid dehalogenase activity" EXACT [EC:3.8.1.2]
synonym: "2-haloalkanoid acid halidohydrolase activity" EXACT [EC:3.8.1.2]
synonym: "2-halocarboxylic acid dehalogenase II activity" EXACT [EC:3.8.1.2]
synonym: "DL-2-haloacid dehalogenase activity" EXACT [EC:3.8.1.2]
synonym: "halocarboxylic acid halidohydrolase activity" EXACT [EC:3.8.1.2]
synonym: "L-2-haloacid dehalogenase activity" EXACT [EC:3.8.1.2]
synonym: "L-DEX activity" EXACT [EC:3.8.1.2]
xref: EC:3.8.1.2
xref: MetaCyc:2-HALOACID-DEHALOGENASE-RXN
xref: UM-BBD_reactionID:r0090
is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds

[Term]
id: GO:0018785
name: haloacetate dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: haloacetate + H2O = glycolate + halide." [EC:3.8.1.3]
subset: gosubset_prok
synonym: "haloacetate halidohydrolase activity" EXACT [EC:3.8.1.3]
synonym: "monohaloacetate dehalogenase activity" EXACT [EC:3.8.1.3]
xref: EC:3.8.1.3
xref: MetaCyc:HALOACETATE-DEHALOGENASE-RXN
xref: UM-BBD_enzymeID:e0006
is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds

[Term]
id: GO:0018786
name: haloalkane dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-haloalkane + H2O = a primary alcohol + halide." [EC:3.8.1.5]
subset: gosubset_prok
synonym: "1-chlorohexane halidohydrolase activity" EXACT [EC:3.8.1.5]
synonym: "1-haloalkane dehalogenase activity" EXACT [EC:3.8.1.5]
synonym: "1-haloalkane halidohydrolase activity" EXACT [EC:3.8.1.5]
xref: EC:3.8.1.5
xref: MetaCyc:HALOALKANE-DEHALOGENASE-RXN
xref: RHEA:25188
xref: UM-BBD_enzymeID:e0003
is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds

[Term]
id: GO:0018787
name: 4-chlorobenzoyl-CoA dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-chlorobenzoyl-CoA + H2O = 4-hydroxybenzoyl CoA + chloride." [EC:3.8.1.7]
synonym: "4-chlorobenzoyl CoA chlorohydrolase activity" EXACT [EC:3.8.1.7]
xref: EC:3.8.1.7
xref: MetaCyc:3.8.1.7-RXN
xref: RHEA:14856
xref: UM-BBD_enzymeID:e0113
is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds

[Term]
id: GO:0018788
name: atrazine chlorohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: atrazine + H(2)O = 4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine + chloride + H(+)." [EC:3.8.1.8, RHEA:11315]
subset: gosubset_prok
synonym: "AtzA" RELATED [EC:3.8.1.8]
xref: EC:3.8.1.8
xref: KEGG:R05558
xref: MetaCyc:3.8.1.8-RXN
xref: RHEA:11315
xref: UM-BBD_reactionID:r0113
is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds

[Term]
id: GO:0018789
name: cyclamate sulfohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyclohexylsulfamate + H(2)O = cyclohexylamine + sulfate." [EC:3.10.1.2, RHEA:18484]
synonym: "cyclamate sulfamatase activity" EXACT []
synonym: "cyclamate sulfamidase activity" EXACT [EC:3.10.1.2]
synonym: "cyclamate sulphohydrolase activity" EXACT []
synonym: "cyclohexylsulfamate sulfamidase activity" EXACT [EC:3.10.1.2]
synonym: "cyclohexylsulfamate sulfohydrolase activity" EXACT [EC:3.10.1.2]
xref: EC:3.10.1.2
xref: KEGG:R02564
xref: MetaCyc:CYCLAMATE-SULFOHYDROLASE-RXN
xref: RHEA:18484
xref: UM-BBD_reactionID:r0755
is_a: GO:0016826 ! hydrolase activity, acting on acid sulfur-nitrogen bonds

[Term]
id: GO:0018791
name: 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate = CO2 + 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate." [UM-BBD_reactionID:r0398]
xref: EC:4.1.1.-
xref: UM-BBD_reactionID:r0398
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0018792
name: bis(4-chlorophenyl)acetate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: bis(4-chlorophenyl)acetate + H+ = CO2 + bis(4-chlorophenyl)methane. Bis(4-chlorophenyl)acetate is also known as DDA; bis(4-chlorophenyl)methane is also known as DDM." [UM-BBD_reactionID:r0520]
synonym: "DDA decarboxylase activity" EXACT []
xref: EC:4.1.1.-
xref: UM-BBD_reactionID:r0520
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0018793
name: 3,5-dibromo-4-hydroxybenzoate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,5-dibromo-4-hydroxybenzoate + H+ = CO2 + 2,6-dibromophenol." [UM-BBD_reactionID:r0546]
xref: EC:4.1.1.-
xref: UM-BBD_reactionID:r0546
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0018794
name: 2-hydroxyisobutyrate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxyisobutyrate + H+ = CO2 + 2-propanol." [UM-BBD_reactionID:r0617]
xref: EC:4.1.1.-
xref: UM-BBD_reactionID:r0617
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0018795
name: 2-hydroxy-2-methyl-1,3-dicarbonate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxy-2-methyl-1,3-dicarbonate + H+ = CO2 + L-lactate." [UM-BBD_reactionID:r0621]
xref: EC:4.1.1.-
xref: UM-BBD_reactionID:r0621
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0018796
name: 4,5-dihydroxyphthalate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4,5-dihydroxyphthalate = 3,4-dihydroxybenzoate + CO2." [EC:4.1.1.55]
subset: gosubset_prok
synonym: "4,5-dihydroxyphthalate carboxy-lyase (3,4-dihydroxybenzoate-forming)" EXACT [EC:4.1.1.55]
synonym: "4,5-dihydroxyphthalate carboxy-lyase activity" EXACT [EC:4.1.1.55]
xref: EC:4.1.1.55
xref: MetaCyc:45-DIHYDROXYPHTHALATE-DECARBOXYLASE-RXN
xref: RHEA:24187
xref: UM-BBD_enzymeID:e0106
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0018798
name: gallate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: gallate + H(+) = CO(2) + pyrogallol." [EC:4.1.1.59, RHEA:12752]
synonym: "gallate carboxy-lyase (pyrogallol-forming)" EXACT [EC:4.1.1.59]
synonym: "gallate carboxy-lyase activity" EXACT [EC:4.1.1.59]
synonym: "gallic acid decarboxylase activity" EXACT []
xref: EC:4.1.1.59
xref: KEGG:R03247
xref: MetaCyc:GALLATE-DECARBOXYLASE-RXN
xref: RHEA:12752
xref: UM-BBD_reactionID:r0005
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0018799
name: 4-hydroxybenzoate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxybenzoate + H(+) = CO(2) + phenol." [EC:4.1.1.61, RHEA:10879]
subset: gosubset_prok
synonym: "4-hydroxybenzoate carboxy-lyase (phenol-forming)" EXACT [EC:4.1.1.61]
synonym: "4-hydroxybenzoate carboxy-lyase activity" EXACT [EC:4.1.1.61]
synonym: "p-hydroxybenzoate decarboxylase activity" EXACT [EC:4.1.1.61]
xref: EC:4.1.1.61
xref: KEGG:R01238
xref: MetaCyc:4-HYDROXYBENZOATE-DECARBOXYLASE-RXN
xref: RHEA:10879
xref: UM-BBD_reactionID:r0159
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0018800
name: 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-oxopent-3-ene-1,2,5-tricarboxylate = 2-oxohept-3-enedioate + CO2." [EC:4.1.1.68]
subset: gosubset_prok
synonym: "5-carboxymethyl-2-oxo-hex-3-ene-1,6-dioate decarboxylase activity" EXACT [EC:4.1.1.68]
synonym: "5-carboxymethyl-2-oxo-hex-3-ene-1,7-dioate decarboxylase activity" EXACT []
synonym: "5-oxopent-3-ene-1,2,5-tricarboxylate carboxy-lyase (2-oxohept-3-enedioate-forming)" EXACT [EC:4.1.1.68]
synonym: "5-oxopent-3-ene-1,2,5-tricarboxylate carboxy-lyase activity" EXACT [EC:4.1.1.68]
synonym: "HpaG-2" RELATED []
synonym: "HpaG2" RELATED []
synonym: "OPET decarboxylase activity" EXACT []
xref: EC:4.1.1.68
xref: MetaCyc:4.1.1.68-RXN
xref: RHEA:14400
xref: UM-BBD_reactionID:r0367
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0018801
name: glutaconyl-CoA decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-glutaconyl-CoA + H(+) = but-2-enoyl-CoA + CO(2)." [EC:4.1.1.70, RHEA:23975]
subset: gosubset_prok
synonym: "4-carboxybut-2-enoyl-CoA carboxy-lyase (but-2-enoyl-CoA-forming)" EXACT [EC:4.1.1.70]
synonym: "4-carboxybut-2-enoyl-CoA carboxy-lyase activity" EXACT [EC:4.1.1.70]
synonym: "glutaconyl coenzyme A decarboxylase activity" EXACT [EC:4.1.1.70]
synonym: "pent-2-enoyl-CoA carboxy-lyase activity" EXACT [EC:4.1.1.70]
xref: EC:4.1.1.70
xref: KEGG:R03028
xref: MetaCyc:GLUTACONYL-COA-DECARBOXYLASE-RXN
xref: RHEA:23975
xref: UM-BBD_reactionID:r0199
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0018802
name: 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4-dihydroxy-hept-trans-2-ene-1,7-dioate = pyruvate + succinic semialdehyde." [UM-BBD_reactionID:r0370]
xref: EC:4.1.2.-
xref: UM-BBD_reactionID:r0370
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0018803
name: 4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate = 2-carboxybenzaldehyde + pyruvate." [EC:4.1.2.34]
synonym: "(3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-carboxybenzaldehyde-lyase activity" NARROW [EC:4.1.2.34]
synonym: "(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-carboxybenzaldehyde-lyase (pyruvate-forming)" EXACT [EC:4.1.2.34]
synonym: "(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-carboxybenzaldehyde-lyase activity" NARROW [EC:4.1.2.34]
synonym: "2'-carboxybenzalpyruvate aldolase activity" EXACT [EC:4.1.2.34]
synonym: "trans-2'-carboxybenzalpyruvate hydratase-aldolase activity" EXACT []
xref: EC:4.1.2.34
xref: MetaCyc:4.1.2.34-RXN
xref: RHEA:16456
xref: UM-BBD_reactionID:r0487
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0018805
name: benzylsuccinate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: fumarate + toluene = 2-benzylsuccinate." [EC:4.1.99.11, RHEA:10419]
synonym: "benzylsuccinate fumarate-lyase (toluene-forming)" EXACT [EC:4.1.99.11]
synonym: "benzylsuccinate fumarate-lyase activity" EXACT [EC:4.1.99.11]
xref: EC:4.1.99.11
xref: KEGG:R05598
xref: MetaCyc:RXN-863
xref: RHEA:10419
xref: UM-BBD_enzymeID:e0259
is_a: GO:0016830 ! carbon-carbon lyase activity

[Term]
id: GO:0018807
name: 6-hydroxycyclohex-1-ene-1-carboxyl-CoA hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-hydroxycyclohex-1-ene-1-carboxyl-CoA + H2O = 2,6-dihydroxycyclohexane-1-carboxyl-CoA." [UM-BBD_reactionID:r0204]
xref: EC:4.2.1.-
xref: UM-BBD_reactionID:r0204
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0018808
name: trans-4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate hydratase-aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate + H2O = pyruvate + 1-hydroxy-2-naphthaldehyde." [UM-BBD_reactionID:r0484]
xref: EC:4.2.1.-
xref: UM-BBD_reactionID:r0484
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0018809
name: E-phenylitaconyl-CoA hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: E-phenylitaconyl-CoA + H2O = (hydroxymethylphenyl)succinyl-CoA." [UM-BBD_reactionID:r0331]
xref: EC:4.2.1.-
xref: UM-BBD_reactionID:r0331
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0018810
name: trans-4-[2-(3-hydroxy)-thionaphthenyl]-2-oxo-3-butenoate hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate + H2O = pyruvate + 3-hydroxy-2-formylbenzothiophene." [UM-BBD_reactionID:r0164]
xref: EC:4.2.1.-
xref: UM-BBD_reactionID:r0164
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0018811
name: cyclohex-1-ene-1-carboxyl-CoA hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyclohex-1-ene-1-carboxyl-CoA + H2O = 2-hydroxycyclohexane-1-carboxyl-CoA." [MetaCyc:R266-RXN, UM-BBD_reactionID:r0191]
xref: EC:4.2.1.-
xref: MetaCyc:R266-RXN
xref: UM-BBD_reactionID:r0191
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0018812
name: 3-hydroxyacyl-CoA dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: alkene-CoA + H2O = alcohol-CoA. Substrates are crotonoyl-CoA (producing 3-hydroxyacyl-CoA) and 2,3-didehydro-pimeloyl-CoA (producing 3-hydroxypimeloyl-CoA)." [UM-BBD_ruleID:bt0291]
xref: EC:4.2.1.-
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0018813
name: trans-o-hydroxybenzylidenepyruvate hydratase-aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxo-3-enoate-4-benzenoid + H2O = pyruvate + benzaldehyde derivative. Substrates are (3E)-4-(5-amino-2-hydroxy-phenyl)-2-oxo-but-3-ene-1-oic-acid (forms 5-aminosalicylaldehyde) and trans-o-hydroxybenzylidenepyruvate (forms salicylaldehyde)." [UM-BBD_enzymeID:e0257]
xref: EC:4.2.1.-
xref: UM-BBD_enzymeID:e0257
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0018814
name: phenylacetaldoxime dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (trans)-phenylacetaldoxime = H(2)O + phenylacetonitrile." [EC:4.99.1.7, RHEA:20072]
synonym: "(Z)-phenylacetaldehyde-oxime hydro-lyase (phenylacetonitrile-forming) activity" EXACT [EC:4.99.1.7]
synonym: "(Z)-phenylacetaldehyde-oxime hydro-lyase activity" EXACT [EC:4.99.1.7]
synonym: "arylacetaldoxime dehydratase activity" EXACT [EC:4.99.1.7]
synonym: "OxdB" RELATED [EC:4.99.1.7]
synonym: "PAOx dehydratase activity" EXACT [EC:4.99.1.7]
xref: EC:4.99.1.7
xref: KEGG:R07638
xref: MetaCyc:4.99.1.7-RXN
xref: RHEA:20072
xref: UM-BBD_reactionID:r0697
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0018815
name: 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon hydratase-aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon + H2O = 2-oxobut-3-enanoate + 2,5,6-trihydroxy-3-methylpyridine." [MetaCyc:RXN-645, UM-BBD_reactionID:r0051]
xref: EC:4.2.1.-
xref: MetaCyc:RXN-645
xref: UM-BBD_reactionID:r0051
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0018816
name: 2-hydroxyisobutyrate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxyisobutyrate = H2O + methacrylate." [UM-BBD_reactionID:r0618]
xref: EC:4.2.1.-
xref: UM-BBD_reactionID:r0618
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0018817
name: 2-oxo-hept-3-ene-1,7-dioate hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-2-oxohept-3-ene-1,7-dioate + H2O = 2,4-dihydroxy-hept-trans-2-ene-1,7-dioate." [UM-BBD_reactionID:r0369]
subset: gosubset_prok
synonym: "2-oxo-hepta-3-ene-1,7-dioate hydratase activity" EXACT []
synonym: "2-oxo-hepta-3-ene-1,7-dioic acid hydratase activity" EXACT []
synonym: "HpaH" RELATED []
xref: EC:4.2.1.-
xref: MetaCyc:HYDROXYHEPTA-DIENEDIOATE-HYDROXY-RXN
xref: UM-BBD_reactionID:r0369
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0018818
name: acetylene hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetaldehyde = acetylene + H(2)O." [EC:4.2.1.112, RHEA:17888]
synonym: "acetaldehyde hydro-lyase activity" EXACT [EC:4.2.1.112]
synonym: "AH" RELATED [EC:4.2.1.112]
synonym: "AHy" RELATED [EC:4.2.1.112]
xref: EC:4.2.1.112
xref: KEGG:R05380
xref: MetaCyc:R141-RXN
xref: RHEA:17888
xref: UM-BBD_reactionID:r0591
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0018819
name: lactoyl-CoA dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: lactoyl-CoA = acryloyl-CoA + H2O." [EC:4.2.1.54]
synonym: "acrylyl coenzyme A hydratase activity" EXACT [EC:4.2.1.54]
synonym: "lactoyl coenzyme A dehydratase activity" EXACT [EC:4.2.1.54]
synonym: "lactoyl-CoA hydro-lyase (acryloyl-CoA-forming)" EXACT [EC:4.2.1.54]
synonym: "lactoyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.54]
synonym: "lactyl CoA dehydratase activity" EXACT [EC:4.2.1.54]
synonym: "lactyl-coenzyme A dehydrase activity" EXACT [EC:4.2.1.54]
xref: EC:4.2.1.54
xref: MetaCyc:LACTOYL-COA-DEHYDRATASE-RXN
xref: MetaCyc:RXN-781
xref: RHEA:21059
xref: UM-BBD_reactionID:r0086
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0018820
name: cyanamide hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: urea = cyanamide + H(2)O." [EC:4.2.1.69, RHEA:23059]
synonym: "urea hydro-lyase (cyanamide-forming)" EXACT [EC:4.2.1.69]
synonym: "urea hydro-lyase activity" EXACT [EC:4.2.1.69]
xref: EC:4.2.1.69
xref: KEGG:R00778
xref: MetaCyc:CYANAMIDE-HYDRATASE-RXN
xref: RHEA:23059
xref: UM-BBD_reactionID:r0668
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0018822
name: nitrile hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: an aliphatic amide = a nitrile + H2O." [EC:4.2.1.84]
subset: gosubset_prok
synonym: "3-cyanopyridine hydratase activity" EXACT [EC:4.2.1.84]
synonym: "acrylonitrile hydratase activity" EXACT [EC:4.2.1.84]
synonym: "aliphatic nitrile hydratase activity" EXACT [EC:4.2.1.84]
synonym: "aliphatic-amide hydro-lyase (nitrile-forming)" EXACT [EC:4.2.1.84]
synonym: "H-NHase activity" EXACT [EC:4.2.1.84]
synonym: "L-NHase activity" EXACT [EC:4.2.1.84]
synonym: "NHase activity" EXACT [EC:4.2.1.84]
synonym: "nitrile hydro-lyase activity" EXACT [EC:4.2.1.84]
xref: EC:4.2.1.84
xref: MetaCyc:NITRILE-HYDRATASE-RXN
xref: UM-BBD_enzymeID:e0067
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0018823
name: cyclohexa-1,5-dienecarbonyl-CoA hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyclohexa-1,5-diene-1-carbonyl-CoA + H(2)O = 6-hydroxycyclohex-1-enecarbonyl-CoA." [EC:4.2.1.100, RHEA:21859]
subset: gosubset_prok
synonym: "6-hydroxycyclohex-1-enecarbonyl-CoA (cyclohexa-1,5-dienecarbonyl-CoA-forming)" RELATED [EC:4.2.1.100]
synonym: "cyclohex-1,5-diene-1-carbonyl-CoA hydratase activity" EXACT []
synonym: "cyclohexa-1,5-diene-1-carbonyl-CoA hydratase activity" EXACT [EC:4.2.1.100]
synonym: "cyclohexa-1,5-diene-1-carboxyl-CoA hydratase activity" EXACT [EC:4.2.1.100]
synonym: "cyclohexa-1,5-dienecarbonyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.100]
synonym: "dienoyl-CoA hydratase activity" EXACT [EC:4.2.1.100]
xref: EC:4.2.1.100
xref: KEGG:R05597
xref: MetaCyc:4.2.1.100-RXN
xref: RHEA:21859
xref: UM-BBD_reactionID:r0203
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0018824
name: (hydroxyamino)benzene mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: (hydroxyamino)benzene = 2-aminophenol." [EC:5.4.4.1, UM-BBD_reactionID:r0304]
synonym: "(hydroxyamino)benzene hydroxymutase activity" EXACT [EC:5.4.4.1]
synonym: "HAB mutase activity" EXACT [EC:5.4.4.1]
synonym: "hydroxylaminobenzene hydroxymutase activity" EXACT [EC:5.4.4.1]
synonym: "hydroxylaminobenzene mutase activity" EXACT [EC:5.4.4.1]
xref: MetaCyc:5.4.4.1-RXN
xref: UM-BBD_reactionID:r0304
is_a: GO:0050486 ! intramolecular transferase activity, transferring hydroxy groups

[Term]
id: GO:0018825
name: triethanolamine lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: triethanolamine = diethanolamine + acetaldehyde." [UM-BBD_enzymeID:e0421]
xref: EC:4.3.3.-
xref: UM-BBD_enzymeID:e0421
is_a: GO:0016843 ! amine-lyase activity

[Term]
id: GO:0018826
name: methionine gamma-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-methionine = methanethiol + NH3 + 2-oxobutanoate." [EC:4.4.1.11]
subset: gosubset_prok
synonym: "L-methioninase activity" EXACT [EC:4.4.1.11]
synonym: "L-methionine gamma-lyase activity" EXACT [EC:4.4.1.11]
synonym: "L-methionine methanethiol-lyase (deaminating)" EXACT [EC:4.4.1.11]
synonym: "L-methionine methanethiol-lyase (deaminating; 2-oxobutanoate-forming)" EXACT [EC:4.4.1.11]
synonym: "methioninase activity" EXACT [EC:4.4.1.11]
synonym: "methionine dethiomethylase activity" EXACT [EC:4.4.1.11]
synonym: "methionine lyase activity" EXACT [EC:4.4.1.11]
xref: EC:4.4.1.11
xref: MetaCyc:METHIONINE-GAMMA-LYASE-RXN
xref: RHEA:24750
xref: UM-BBD_reactionID:r0432
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0018827
name: 1-chloro-2,2-bis(4-chlorophenyl)ethane dehydrochlorinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-chloro-2,2-bis(4-chlorophenyl)ethane = HCl + unsym-bis(4-chlorophenyl)ethene. 1-chloro-2,2-bis(4-chlorophenyl)ethane is also known as DDMS; unsym-bis(4-chlorophenyl)ethene is also known as DDNU." [UM-BBD_reactionID:r0515]
synonym: "DDMS dehydrochlorinase activity" EXACT []
xref: EC:4.5.1.-
xref: UM-BBD_reactionID:r0515
is_a: GO:0016848 ! carbon-halide lyase activity

[Term]
id: GO:0018828
name: halohydrin hydrogen-halide-lyase A activity
namespace: molecular_function
def: "Catalysis of the elimination of HCl from a chloro- or bromopropanol, yielding an epoxypropane." [UM-BBD_enzymeID:e0048]
xref: EC:4.5.1.-
xref: UM-BBD_enzymeID:e0048
is_a: GO:0019181 ! halohydrin hydrogen-halide-lyase activity

[Term]
id: GO:0018829
name: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane dehydrochlorinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane = HCl + 1-chloro-2,2-bis(4-chlorophenyl)ethene. 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane is also known as DDD; 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU." [UM-BBD_reactionID:r0513]
synonym: "DDD dehydrochlorinase activity" EXACT []
xref: EC:4.5.1.-
xref: UM-BBD_reactionID:r0513
is_a: GO:0016848 ! carbon-halide lyase activity

[Term]
id: GO:0018830
name: gamma-hexachlorocyclohexane dehydrochlorinase activity
namespace: molecular_function
def: "Catalysis of the reaction: gamma-hexachlorocyclohexane + HCl = 1,3(R),4(S),5(S),6(R)-pentachlorocyclohexene." [UM-BBD_enzymeID:e0359]
xref: EC:4.5.1.-
xref: UM-BBD_enzymeID:e0359
is_a: GO:0016848 ! carbon-halide lyase activity

[Term]
id: GO:0018831
name: 5-chloro-1,2,4-trihydroxybenzene dechlorinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-chloro-1,2,4-trihydroxybenzene = Cl- + H+ + 2-hydroxy-1,4-benzoquinone." [UM-BBD_reactionID:r0666]
xref: EC:4.5.1.-
xref: UM-BBD_reactionID:r0666
is_a: GO:0016848 ! carbon-halide lyase activity

[Term]
id: GO:0018832
name: halohydrin hydrogen-halide-lyase B activity
namespace: molecular_function
def: "Catalysis of the elimination of HCl from a chloropropanol, yielding an epoxypropane." [UM-BBD_enzymeID:e0050]
xref: EC:4.5.1.-
xref: UM-BBD_enzymeID:e0050
is_a: GO:0019181 ! halohydrin hydrogen-halide-lyase activity

[Term]
id: GO:0018833
name: DDT-dehydrochlorinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane = 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride + H(+)." [EC:4.5.1.1, RHEA:19220]
synonym: "1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane chloride-lyase [1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene-forming]" RELATED [EC:4.5.1.1]
synonym: "1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane chloride-lyase activity" EXACT [EC:4.5.1.1]
synonym: "DDT dehydrochlorinase activity" EXACT []
synonym: "DDT-as" RELATED [EC:4.5.1.1]
synonym: "DDT-ase activity" EXACT [EC:4.5.1.1]
synonym: "DDTase activity" EXACT [EC:4.5.1.1]
xref: EC:4.5.1.1
xref: KEGG:R04522
xref: MetaCyc:DDT-DEHYDROCHLORINASE-RXN
xref: RHEA:19220
xref: UM-BBD_reactionID:r0439
is_a: GO:0016848 ! carbon-halide lyase activity

[Term]
id: GO:0018834
name: dichloromethane dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: dichloromethane + H(2)O = 2 chloride + formaldehyde + 2 H(+)." [EC:4.5.1.3, RHEA:15400]
subset: gosubset_prok
synonym: "dichloromethane chloride-lyase (adding H2O; chloride-hydrolysing; formaldehyde-forming)" EXACT [EC:4.5.1.3]
synonym: "dichloromethane chloride-lyase (chloride-hydrolysing)" EXACT [EC:4.5.1.3]
xref: EC:4.5.1.3
xref: KEGG:R00603
xref: MetaCyc:DICHLOROMETHANE-DEHALOGENASE-RXN
xref: RHEA:15400
xref: UM-BBD_reactionID:r0188
is_a: GO:0016848 ! carbon-halide lyase activity

[Term]
id: GO:0018835
name: carbon phosphorus lyase activity
namespace: molecular_function
alt_id: GO:0009456
def: "Catalysis of the reaction: alkylphosphonic acid = R-CH3 + phosphate. Substrates include aminomethylphosphonic acid (AMPA) (forms methylamine), dimethylphosphinic acid (forms methylphosphonic acid), glyphosate (forms sarcosine) and methylphosphonic acid (forms phosphate)." [PMID:3804975]
xref: EC:4.7.1
is_a: GO:0016829 ! lyase activity

[Term]
id: GO:0018836
name: alkylmercury lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: R-Hg+ + H+ = R-H + Hg2+." [EC:4.99.1.2]
subset: gosubset_prok
synonym: "alkylmercury mercuric-lyase (alkane-forming)" EXACT [EC:4.99.1.2]
synonym: "alkylmercury mercuric-lyase activity" EXACT [EC:4.99.1.2]
synonym: "organomercurial lyase activity" EXACT [EC:4.99.1.2]
synonym: "organomercury lyase activity" EXACT [EC:4.99.1.2]
xref: EC:4.99.1.2
xref: MetaCyc:ALKYLMERCURY-LYASE-RXN
xref: UM-BBD_enzymeID:e0055
is_a: GO:0016829 ! lyase activity

[Term]
id: GO:0018837
name: 2-hydroxy-2H-benzo[h]chromene-2-carboxylate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxy-2 H-benzo[h]chromene-2-carboxylate = cis -4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate." [UM-BBD_reactionID:r0502]
xref: EC:5.1.2.-
xref: UM-BBD_reactionID:r0502
is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives

[Term]
id: GO:0018838
name: mandelate racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-mandelate = (R)-mandelate." [EC:5.1.2.2]
subset: gosubset_prok
xref: EC:5.1.2.2
xref: MetaCyc:MANDELATE-RACEMASE-RXN
xref: RHEA:13948
xref: UM-BBD_reactionID:r0091
is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives

[Term]
id: GO:0018839
name: cis-4-[2-(3-hydroxy)-thionaphthenyl]-2-oxo-3-butenoate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate = trans-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate." [UM-BBD_reactionID:r0163]
xref: EC:5.2.1.-
xref: UM-BBD_reactionID:r0163
is_a: GO:0016859 ! cis-trans isomerase activity

[Term]
id: GO:0018842
name: 3-carboxymuconate cycloisomerase type II activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-sulfomuconate = 4-sulfolactone." [UM-BBD_reactionID:r0582]
subset: gosubset_prok
xref: EC:5.3.3.-
xref: UM-BBD_reactionID:r0582
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0018844
name: 2-hydroxytetrahydrofuran isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxytetrahydrofuran = 4-hydroxybutyraldehyde." [UM-BBD_reactionID:r0019]
xref: EC:5.3.99.-
xref: UM-BBD_reactionID:r0019
is_a: GO:0016860 ! intramolecular oxidoreductase activity

[Term]
id: GO:0018845
name: 2-hydroxychromene-2-carboxylate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxychromene-2-carboxylate = (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate. (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate is also known as trans-o-hydroxybenzylidenepyruvate." [RHEA:27404]
xref: EC:5.99.1.4
xref: KEGG:R05137
xref: MetaCyc:RXNN-386
xref: RHEA:27404
xref: UM-BBD_reactionID:r0337
is_a: GO:0016860 ! intramolecular oxidoreductase activity

[Term]
id: GO:0018846
name: styrene-oxide isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: styrene oxide = phenylacetaldehyde." [EC:5.3.99.7, RHEA:21607]
synonym: "SOI activity" EXACT [EC:5.3.99.7]
synonym: "styrene oxide isomerase activity" EXACT []
synonym: "styrene-oxide isomerase (epoxide-cleaving)" EXACT [EC:5.3.99.7]
xref: EC:5.3.99.7
xref: KEGG:R02615
xref: MetaCyc:STYRENE-OXIDE-ISOMERASE-RXN
xref: RHEA:21607
xref: UM-BBD_reactionID:r0034
is_a: GO:0016860 ! intramolecular oxidoreductase activity

[Term]
id: GO:0018847
name: alpha-pinene lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-pinene = limonene." [UM-BBD_reactionID:r0712]
xref: EC:5.5.1.-
xref: UM-BBD_reactionID:r0712
is_a: GO:0016872 ! intramolecular lyase activity

[Term]
id: GO:0018848
name: pinocarveol isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: pinocarveol = carveol." [UM-BBD_reactionID:r0715]
xref: EC:5.5.1.-
xref: UM-BBD_reactionID:r0715
is_a: GO:0016872 ! intramolecular lyase activity

[Term]
id: GO:0018849
name: muconate cycloisomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,5-dihydro-5-oxofuran-2-acetate = cis,cis-hexadienedioate." [EC:5.5.1.1]
subset: gosubset_prok
synonym: "2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)" EXACT [EC:5.5.1.1]
synonym: "4-carboxymethyl-4-hydroxyisocrotonolactone lyase (decyclizing)" EXACT [EC:5.5.1.1]
synonym: "cis,cis-muconate cycloisomerase activity" EXACT [EC:5.5.1.1]
synonym: "cis,cis-muconate lactonizing enzyme I activity" EXACT [EC:5.5.1.1]
synonym: "cis,cis-muconate-lactonizing enzyme" RELATED [EC:5.5.1.1]
synonym: "muconate cycloisomerase I activity" EXACT [EC:5.5.1.1]
synonym: "muconate lactonizing enzyme activity" EXACT [EC:5.5.1.1]
xref: EC:5.5.1.1
xref: MetaCyc:MUCONATE-CYCLOISOMERASE-RXN
xref: RHEA:10643
xref: UM-BBD_enzymeID:e0133
is_a: GO:0016872 ! intramolecular lyase activity

[Term]
id: GO:0018850
name: chloromuconate cycloisomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-chloro-2,5-dihydro-5-oxofuran-2-acetate = 3-chloro-cis,cis-muconate." [EC:5.5.1.7]
subset: gosubset_prok
synonym: "2-chloro-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)" EXACT [EC:5.5.1.7]
synonym: "muconate cycloisomerase II activity" EXACT [EC:5.5.1.7]
xref: EC:5.5.1.7
xref: RHEA:11035
xref: UM-BBD_enzymeID:e0065
is_a: GO:0016872 ! intramolecular lyase activity

[Term]
id: GO:0018851
name: alpha-pinene-oxide decyclase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-pinene oxide = (Z)-2-methyl-5-isopropylhexa-2,5-dienal." [EC:5.5.1.10, RHEA:16696]
synonym: "alpha-pinene oxide lyase activity" EXACT []
synonym: "alpha-pinene-oxide lyase (decyclizing)" EXACT [EC:5.5.1.10]
xref: EC:5.5.1.10
xref: KEGG:R04040
xref: MetaCyc:ALPHA-PINENE-OXIDE-DECYCLASE-RXN
xref: RHEA:16696
xref: UM-BBD_reactionID:r0743
is_a: GO:0016872 ! intramolecular lyase activity

[Term]
id: GO:0018852
name: dichloromuconate cycloisomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate = 2,4-dichloro-cis,cis-muconate." [EC:5.5.1.11]
synonym: "2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)" EXACT [EC:5.5.1.11]
xref: EC:5.5.1.11
xref: MetaCyc:DICHLOROMUCONATE-CYCLOISOMERASE-RXN
xref: RHEA:17440
xref: UM-BBD_reactionID:r0277
is_a: GO:0016872 ! intramolecular lyase activity

[Term]
id: GO:0018853
name: obsolete perillyl-CoA synthetase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: perillic acid + CoA-SH + ATP = H2O + ADP/AMP + mono/diphosphate + perillyl-CoA." [UM-BBD_reactionID:r0731]
comment: This term was made obsolete because it represents two reactions.
synonym: "perillyl-CoA synthetase activity" EXACT []
xref: EC:6.2.1.-
xref: UM-BBD_reactionID:r0731
is_obsolete: true
consider: GO:0052685
consider: GO:0052686

[Term]
id: GO:0018854
name: 3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3R)-3-isopropenyl-6-oxoheptanoate + CoA-SH + ATP = H2O + ADP/AMP + mono/diphosphate + (3R)-3-isopropenyl-6-oxoheptanoyl-CoA." [UM-BBD_reactionID:r0737]
xref: EC:6.2.1.-
xref: UM-BBD_reactionID:r0737
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0018855
name: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetate + ATP + CoA = AMP + diphosphate + 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA." [UM-BBD_reactionID:r0429]
xref: EC:6.2.1.-
xref: UM-BBD_reactionID:r0429
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0018856
name: benzoyl acetate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-oxo-3-phenylpropionate + CoA + ATP = AMP + diphosphate + benzoyl acetyl-CoA." [UM-BBD_reactionID:r0242]
xref: EC:6.2.1.-
xref: KEGG:R05452
xref: SABIO-RK:5058
xref: UM-BBD_reactionID:r0242
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0018857
name: 2,4-dichlorobenzoate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4-dichlorobenzoate + ATP + CoASH = AMP + diphosphate + 2,4-dichlorobenzoyl-CoA." [UM-BBD_reactionID:r0137]
xref: EC:6.2.1.-
xref: UM-BBD_reactionID:r0137
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0018858
name: benzoate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + benzoate + CoA = AMP + benzoyl-CoA + diphosphate + H(+)." [EC:6.2.1.25, RHEA:10135]
subset: gosubset_prok
synonym: "benzoate-coenzyme A ligase activity" EXACT [EC:6.2.1.25]
synonym: "benzoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.25]
synonym: "benzoyl CoA synthetase (AMP forming)" EXACT [EC:6.2.1.25]
synonym: "benzoyl-coenzyme A synthetase activity" EXACT [EC:6.2.1.25]
xref: EC:6.2.1.25
xref: KEGG:R01422
xref: MetaCyc:BENZOATE--COA-LIGASE-RXN
xref: RHEA:10135
xref: UM-BBD_reactionID:r0189
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0018859
name: 4-hydroxybenzoate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 4-hydroxybenzoate + CoA = AMP + diphosphate + 4-hydroxybenzoyl-CoA." [EC:6.2.1.27]
subset: gosubset_prok
synonym: "4-hydroxybenzoate-CoA synthetase activity" EXACT [EC:6.2.1.27]
synonym: "4-hydroxybenzoate-coenzyme A ligase (AMP-forming)" EXACT [EC:6.2.1.27]
synonym: "4-hydroxybenzoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.27]
synonym: "4-hydroxybenzoyl coenzyme A synthetase activity" EXACT [EC:6.2.1.27]
synonym: "4-hydroxybenzoyl-CoA ligase activity" EXACT [EC:6.2.1.27]
xref: EC:6.2.1.27
xref: KEGG:R01300
xref: MetaCyc:4-HYDROXYBENZOATE--COA-LIGASE-RXN
xref: RHEA:23119
xref: UM-BBD_reactionID:r0156
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0018860
name: anthranilate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + anthranilate + CoA = AMP + diphosphate + anthranilyl-CoA." [EC:6.2.1.32]
subset: gosubset_prok
synonym: "2-aminobenzoate coenzyme A ligase activity" EXACT [EC:6.2.1.32]
synonym: "2-aminobenzoate-CoA ligase activity" EXACT [EC:6.2.1.32]
synonym: "2-aminobenzoate-coenzyme A ligase activity" EXACT [EC:6.2.1.32]
synonym: "anthranilate--CoA ligase activity" EXACT []
synonym: "anthranilate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.32]
synonym: "anthraniloyl coenzyme A synthetase activity" EXACT [EC:6.2.1.32]
xref: EC:6.2.1.32
xref: KEGG:R00982
xref: MetaCyc:AMINOBENZCOALIG-RXN
xref: RHEA:10831
xref: UM-BBD_reactionID:r0341
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0018861
name: 4-chlorobenzoate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-chlorobenzoate + CoA + ATP = 4-chlorobenzoyl-CoA + AMP + diphosphate. This reaction requires magnesium and is part of the bacterial 2,4-dichlorobenzoate degradation pathway." [EC:6.2.1.33]
subset: gosubset_prok
synonym: "4-chlorobenzoate:CoA ligase activity" EXACT []
xref: EC:6.2.1.33
xref: KEGG:R03932
xref: MetaCyc:6.2.1.33-RXN
xref: RHEA:23223
xref: UM-BBD_reactionID:r0139
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0018862
name: phenylphosphate carboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenylphosphate + CO2 + H2O = H+ + phosphate + 4-hydroxybenzoate." [UM-BBD_reactionID:r0157]
xref: EC:6.4.1.-
xref: MetaCyc:PHENYLPCARB-RXN
xref: UM-BBD_reactionID:r0157
is_a: GO:0016885 ! ligase activity, forming carbon-carbon bonds

[Term]
id: GO:0018863
name: phenanthrene-9,10-epoxide hydrolase (9S,10S-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9(S),10(S)-dihydrodiolphenanthrene." [UM-BBD_reactionID:r0496]
xref: EC:3.3.2.-
xref: UM-BBD_reactionID:r0496
is_a: GO:0019119 ! phenanthrene-9,10-epoxide hydrolase activity

[Term]
id: GO:0018864
name: acetylene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving acetylene, formula CH2CH2, the simplest of the alkynes." [ISBN:0721662544]
subset: gosubset_prok
synonym: "acetylene metabolism" EXACT []
synonym: "ethyne metabolic process" EXACT []
synonym: "ethyne metabolism" EXACT []
xref: UM-BBD_pathwayID:atl
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0043452 ! cellular alkyne metabolic process

[Term]
id: GO:0018865
name: acrylonitrile metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving acrylonitrile, a colorless, volatile liquid with a pungent odor. Acrylonitrile is used in the production of acrylic fibers, plastics, and synthetic rubbers." [http://www.iversonsoftware.com/reference/chemistry/a/acrylonitrile.htm]
subset: gosubset_prok
synonym: "acrylonitrile metabolism" EXACT []
xref: UM-BBD_pathwayID:acr
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0034641 ! cellular nitrogen compound metabolic process
is_a: GO:0050898 ! nitrile metabolic process

[Term]
id: GO:0018866
name: adamantanone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving adamantanone, tricyclo(3.3.1.13,7)decanone, a white crystalline solid used as an intermediate for microelectronics in the production of photoresists." [GOC:ai]
subset: gosubset_prok
synonym: "adamantanone metabolism" EXACT []
xref: UM-BBD_pathwayID:ada
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0042180 ! cellular ketone metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process

[Term]
id: GO:0018867
name: alpha-pinene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving alpha-pinene, a monoterpene that may be a significant factor affecting bacterial activities in nature. It is a major component in tea-tree oils, and gives off a piney smelling odor." [UM-BBD_pathwayID:apn]
subset: gosubset_prok
synonym: "alpha-pinene metabolism" EXACT []
xref: UM-BBD_pathwayID:apn
is_a: GO:0033073 ! pinene metabolic process

[Term]
id: GO:0018868
name: 2-aminobenzenesulfonate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 2-aminobenzenesulfonate, aniline-o-sulfonic acid, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines." [UM-BBD_pathwayID:abs]
subset: gosubset_prok
synonym: "2-aminobenzenesulfonate metabolism" EXACT []
synonym: "2-aminobenzenesulphonate metabolic process" EXACT []
synonym: "2-aminobenzenesulphonate metabolism" EXACT []
xref: UM-BBD_pathwayID:abs
is_a: GO:0006082 ! organic acid metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0009308 ! amine metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:0018870
name: anaerobic 2-aminobenzoate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 2-aminobenzoate, a derivative of benzoic acid with an NH2 group attached to C2, that occurs in the absence of oxygen." [GOC:ai]
subset: gosubset_prok
synonym: "anaerobic 2-aminobenzoate metabolism" EXACT []
xref: UM-BBD_pathwayID:abz
is_a: GO:0018875 ! anaerobic benzoate metabolic process
is_a: GO:0043420 ! anthranilate metabolic process

[Term]
id: GO:0018871
name: 1-aminocyclopropane-1-carboxylate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 1-aminocyclopropane-1-carboxylate, the anion of 1-aminocyclopropane-1-carboxylic acid, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants." [UM-BBD_pathwayID:acp]
subset: gosubset_prok
synonym: "1-aminocyclopropane-1-carboxylate metabolism" EXACT []
synonym: "ACP metabolic process" EXACT []
synonym: "ACP metabolism" EXACT []
xref: UM-BBD_pathwayID:acp
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:1901605 ! alpha-amino acid metabolic process

[Term]
id: GO:0018872
name: arsonoacetate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving arsonoacetate, a synthetic, organic compound containing a single arsenic atom. Arsonoacetate and other arsenic containing compounds are used in agricultural applications as animal feed additives, cotton defoliants and post-emergence grass herbicides." [UM-BBD_pathwayID:ara]
subset: gosubset_prok
synonym: "arsonoacetate metabolism" EXACT []
xref: UM-BBD_pathwayID:ara
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0018873
name: atrazine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving atrazine, a triazine ring-containing compound, widely used as a herbicide." [UM-BBD_pathwayID:atr]
subset: gosubset_prok
synonym: "atrazine metabolism" EXACT []
xref: UM-BBD_pathwayID:atr
is_a: GO:0018965 ! s-triazine compound metabolic process

[Term]
id: GO:0018874
name: benzoate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving benzoate, the anion of benzoic acid (benzenecarboxylic acid), a fungistatic compound widely used as a food preservative; it is conjugated to glycine in the liver and excreted as hippuric acid." [ISBN:0721662544]
subset: gosubset_prok
synonym: "benzoate metabolism" EXACT []
xref: MetaCyc:P321-PWY
xref: UM-BBD_pathwayID:benz2
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:0018875
name: anaerobic benzoate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving benzoate, the anion of benzoic acid (benzenecarboxylic acid) that occur in the absence of oxygen." [GOC:ai]
subset: gosubset_prok
synonym: "anaerobic benzoate metabolism" EXACT []
xref: MetaCyc:CENTBENZCOA-PWY
xref: UM-BBD_pathwayID:benz
is_a: GO:0018874 ! benzoate metabolic process

[Term]
id: GO:0018876
name: benzonitrile metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving benzonitrile. Benzonitrile is used as a solvent and chemical intermediate in the pharmaceutical, dyestuffs and rubber industries. It is highly toxic and harmful in contact with skin." [UM-BBD_pathwayID:bzn]
subset: gosubset_prok
synonym: "benzonitrile metabolism" EXACT []
xref: UM-BBD_pathwayID:bzn
is_a: GO:0034641 ! cellular nitrogen compound metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process
is_a: GO:0050898 ! nitrile metabolic process

[Term]
id: GO:0018877
name: beta-1,2,3,4,5,6-hexachlorocyclohexane metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving beta-1,2,3,4,5,6-hexachlorocyclohexane, a halogenated organic insecticide that has been used worldwide for agriculture and public health." [UM-BBD_pathwayID:hch]
subset: gosubset_prok
synonym: "beta-1,2,3,4,5,6-hexachlorocyclohexane metabolism" EXACT []
xref: UM-BBD_pathwayID:hch
is_a: GO:0019497 ! hexachlorocyclohexane metabolic process

[Term]
id: GO:0018878
name: aerobic beta-1,2,3,4,5,6-hexachlorocyclohexane metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving beta-1,2,3,4,5,6-hexachlorocyclohexane that occur in presence of oxygen." [GOC:ai]
subset: gosubset_prok
synonym: "aerobic beta-1,2,3,4,5,6-hexachlorocyclohexane metabolism" EXACT []
is_a: GO:0018877 ! beta-1,2,3,4,5,6-hexachlorocyclohexane metabolic process

[Term]
id: GO:0018879
name: biphenyl metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving biphenyl, a toxic aromatic hydrocarbon used as a heat transfer agent, as a fungistat in packaging citrus fruits and in plant disease control. Biphenyl can be chlorinated with 1-10 chlorine molecules to form polychlorinated biphenyls (PCBs)." [GOC:jl]
subset: gosubset_prok
synonym: "biphenyl metabolism" EXACT []
synonym: "xenene metabolic process" EXACT []
synonym: "xenene metabolism" EXACT []
xref: UM-BBD_pathwayID:bph
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:0018880
name: 4-chlorobiphenyl metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 4-chlorobiphenyl, a member of the polychlorinated biphenyl (PCB) group of compounds, a very stable group of synthetic organic compounds composed of a biphenyl nucleus with 1-10 chlorine substituents. 4-chlorobiphenyl has been used as a model substrate to investigate PCB degradation." [GOC:jl]
subset: gosubset_prok
synonym: "4-chlorobiphenyl metabolism" EXACT []
xref: UM-BBD_pathwayID:cbp
is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:0018881
name: bromoxynil metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving bromoxynil, C7H3Br2NO, a dibrominated phenol derivative with a cyano (-CN) group attached. Bromoxynil is used as a herbicide for post-emergent control of annual broadleaf weeds and works by inhibiting photosynthesis in the target plants." [GOC:ai]
subset: gosubset_prok
synonym: "bromoxynil metabolism" EXACT []
xref: UM-BBD_pathwayID:box
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0042197 ! halogenated hydrocarbon metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process
is_a: GO:0050898 ! nitrile metabolic process

[Term]
id: GO:0018882
name: (+)-camphor metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (+)-camphor, a bicyclic monoterpene ketone which is one of the major components in the leaves of common sage. Camphor exists in two enantiomers, but the (+)-isomer is more widely distributed." [UM-BBD_pathwayID:cam]
subset: gosubset_prok
synonym: "(+)-camphor metabolism" EXACT []
synonym: "camphor metabolic process" EXACT []
synonym: "camphor metabolism" EXACT []
xref: UM-BBD_pathwayID:cam
is_a: GO:0016098 ! monoterpenoid metabolic process
is_a: GO:0042180 ! cellular ketone metabolic process

[Term]
id: GO:0018883
name: caprolactam metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving caprolactam, hexahydro-2h-azepin-2-one, a cyclic amide of caproic acid used in manufacture of synthetic fibers of the polyamide type. It can cause local irritation." [CHEBI:23000, GOC:curators]
subset: gosubset_prok
synonym: "caprolactam metabolism" EXACT []
xref: UM-BBD_pathwayID:cap
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0072338 ! cellular lactam metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process

[Term]
id: GO:0018884
name: carbazole metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving carbazole, a heterocyclic aromatic compound containing a dibenzopyrrole system that is produced during coal gasification and is present in cigarette smoke. Coal tar produced at high temperature contains an average of 1.5% carbazole. It is used widely in synthesis of dyes, pharmaceuticals, and plastics and is a suspected carcinogen." [GOC:jl]
subset: gosubset_prok
synonym: "CAR metabolic process" EXACT []
synonym: "CAR metabolism" EXACT []
synonym: "carbazole metabolism" EXACT []
xref: UM-BBD_pathwayID:car
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process

[Term]
id: GO:0018885
name: carbon tetrachloride metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving carbon tetrachloride, a toxic, carcinogenic compound which is used as a general solvent in industrial degreasing operations. It is also used as grain fumigant and a chemical intermediate in the production of refrigerants." [UM-BBD_pathwayID:ctc]
subset: gosubset_prok
synonym: "carbon tetrachloride metabolism" EXACT []
xref: Reactome:REACT_100276 "Dehalogenation of carbon tetrachloride to form a free radical, Mus musculus"
xref: Reactome:REACT_108385 "Dehalogenation of carbon tetrachloride to form a free radical, Danio rerio"
xref: Reactome:REACT_122 "Dehalogenation of carbon tetrachloride to form a free radical, Homo sapiens"
xref: Reactome:REACT_32769 "Dehalogenation of carbon tetrachloride to form a free radical, Sus scrofa"
xref: Reactome:REACT_34597 "Dehalogenation of carbon tetrachloride to form a free radical, Canis familiaris"
xref: Reactome:REACT_78242 "Dehalogenation of carbon tetrachloride to form a free radical, Bos taurus"
xref: Reactome:REACT_83900 "Dehalogenation of carbon tetrachloride to form a free radical, Rattus norvegicus"
xref: Reactome:REACT_99093 "Dehalogenation of carbon tetrachloride to form a free radical, Gallus gallus"
xref: Reactome:REACT_99362 "Dehalogenation of carbon tetrachloride to form a free radical, Taeniopygia guttata"
xref: UM-BBD_pathwayID:ctc
is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process

[Term]
id: GO:0018886
name: anaerobic carbon tetrachloride metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving carbon tetrachloride, a toxic, carcinogenic compound which is used as a general solvent in industrial degreasing operations, that occur in the absence of oxygen." [GOC:ai]
subset: gosubset_prok
synonym: "anaerobic carbon tetrachloride metabolism" EXACT []
xref: UM-BBD_pathwayID:ctc
is_a: GO:0018885 ! carbon tetrachloride metabolic process

[Term]
id: GO:0018887
name: 4-carboxy-4'-sulfoazobenzene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 4-carboxy-4'-sulfoazobenzene, a sulfonated azo compound synthesized by nitro-amine condensation from sulfanilic acid and 4-nitrobenzoic acid." [PMID:9603860]
subset: gosubset_prok
synonym: "4-carboxy-4'-sulfoazobenzene metabolism" EXACT []
synonym: "4-carboxy-4'-sulphoazobenzene metabolic process" EXACT []
synonym: "4-carboxy-4'-sulphoazobenzene metabolism" EXACT []
xref: UM-BBD_pathwayID:csab
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0006807 ! nitrogen compound metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:0018888
name: 3-chloroacrylic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 3-chloroacrylic acid, ClHC=CHCOOH, a chlorinated derivative of acrylic acid." [GOC:ai]
subset: gosubset_prok
synonym: "3-chloroacrylic acid metabolism" EXACT []
xref: UM-BBD_pathwayID:caa
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0018889
name: 2-chloro-N-isopropylacetanilide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 2-chloro-N-isopropylacetanilide, an acylanide herbicide widely used to protect corn, onion, cabbage, rose bushes, and ornamental plants." [UM-BBD_pathwayID:ppc]
subset: gosubset_prok
synonym: "2-chloro-N-isopropylacetanilide metabolism" EXACT []
synonym: "propachlor metabolic process" EXACT []
synonym: "propachlor metabolism" EXACT []
xref: UM-BBD_pathwayID:ppc
is_a: GO:0042537 ! benzene-containing compound metabolic process
is_a: GO:0043603 ! cellular amide metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process

[Term]
id: GO:0018890
name: cyanamide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cyanamide, NCNH2, a cyanide compound which has been used as a fertilizer, defoliant and in many manufacturing processes. It often occurs as the calcium salt, sometimes also referred to as cyanamide. The citrated calcium salt is used in the treatment of alcoholism." [CHEBI:16698, GOC:curators]
subset: gosubset_prok
synonym: "cyanamide metabolism" EXACT []
xref: UM-BBD_pathwayID:cnm
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0050898 ! nitrile metabolic process

[Term]
id: GO:0018891
name: cyclohexanol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cyclohexanol, the monohydroxy derivative of cyclohexane. It is used as a solvent and blending agent." [ISBN:0721662544]
subset: gosubset_prok
synonym: "cyclohexanol metabolism" EXACT []
xref: UM-BBD_pathwayID:chx
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:1902652 ! secondary alcohol metabolic process

[Term]
id: GO:0018892
name: cyclohexylsulfamate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cyclohexylsulfamate, also known as cyclamic acid. Sodium cyclohexylsulfamate (CHS-Na) was a widely used sweetening agent but was banned because of the suspicion of carcinogenicity and metabolic conversion to cyclohexylamine (CHA), a toxic substance. It is now used as a fungicide." [UM-BBD_pathwayID:chs]
subset: gosubset_prok
synonym: "cyclohexylsulfamate metabolism" EXACT []
synonym: "cyclohexylsulphamate metabolic process" EXACT []
synonym: "cyclohexylsulphamate metabolism" EXACT []
xref: UM-BBD_pathwayID:chs
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0043436 ! oxoacid metabolic process

[Term]
id: GO:0018893
name: dibenzofuran metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dibenzofuran, a substance composed of two benzene rings linked by one ether bond and one carbon-carbon bond. Dibenzofuran is a white crystalline solid created from the production of coal tar and used as an insecticide and an intermediate in the production of other chemicals." [GOC:ai, UM-BBD_pathwayID:dbf]
subset: gosubset_prok
synonym: "dibenzofuran metabolism" EXACT []
xref: UM-BBD_pathwayID:dbf
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0044281 ! small molecule metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process

[Term]
id: GO:0018894
name: dibenzo-p-dioxin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dibenzo-p-dioxin, a substance composed of two benzene rings linked by two ether bonds. Dibenzo-p-dioxins are generated as by-products in the manufacturing of herbicides, insecticides, fungicides, paper pulp bleaching, and in incineration, and can accumulate in milk and throughout the food chain, creating significant health concern." [UM-BBD_pathwayID:dpd]
subset: gosubset_prok
synonym: "dibenzo-p-dioxin metabolism" EXACT []
synonym: "oxanthrene metabolic process" EXACT []
synonym: "oxanthrene metabolism" EXACT []
synonym: "phenodioxin metabolic process" EXACT []
synonym: "phenodioxin metabolism" EXACT []
xref: UM-BBD_pathwayID:dpd
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0044281 ! small molecule metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process

[Term]
id: GO:0018895
name: dibenzothiophene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dibenzothiophene, a substance composed of two benzene rings linked by one sulfide bond and one carbon-carbon bond. Dibenzothiophene derivatives can be detected in diesel oil following hydrodesulfurization treatment to remove sulfur compounds that would otherwise generate sulfur oxides during combustion." [PMID:12147483]
subset: gosubset_prok
synonym: "dibenzothiophene metabolism" EXACT []
synonym: "diphenylene sulfide metabolic process" EXACT []
synonym: "diphenylene sulfide metabolism" EXACT []
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process

[Term]
id: GO:0018896
name: dibenzothiophene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dibenzothiophene, a substance composed of two benzene rings linked by one sulfide bond and one carbon-carbon bond." [GOC:ai]
subset: gosubset_prok
synonym: "dibenzothiophene breakdown" EXACT []
synonym: "dibenzothiophene catabolism" EXACT []
synonym: "dibenzothiophene degradation" EXACT []
xref: UM-BBD_pathwayID:dbt2
is_a: GO:0018895 ! dibenzothiophene metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process

[Term]
id: GO:0018897
name: dibenzothiophene desulfurization
namespace: biological_process
def: "The removal of the sulfur atom from dibenzothiophene, a substance composed of two benzene rings linked by one sulfide bond and one carbon-carbon bond." [GOC:ai]
subset: gosubset_prok
synonym: "dibenzothiophene desulphurization" EXACT []
xref: MetaCyc:PWY-681
xref: UM-BBD_pathwayID:dbt
is_a: GO:0018895 ! dibenzothiophene metabolic process

[Term]
id: GO:0018898
name: 2,4-dichlorobenzoate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 2,4-dichlorobenzoate, a chlorinated aromatic compound which is a key intermediate in the aerobic degradation of polychlorinated biphenyls (PCBs)." [GOC:jl, UM-BBD_pathwayID:dcb]
subset: gosubset_prok
synonym: "2,4-dichlorobenzoate metabolism" EXACT []
xref: UM-BBD_pathwayID:dcb
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:0018899
name: 1,2-dichloroethane metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 1,2-dichloroethane, a major commodity chemical used, for example, in the manufacture of vinyl chloride." [GOC:jl]
subset: gosubset_prok
synonym: "1,2-dichloroethane metabolism" EXACT []
xref: UM-BBD_pathwayID:dce
is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process

[Term]
id: GO:0018900
name: dichloromethane metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dichloromethane, a dichlorinated derivative of methane. It is a colorless organic liquid with a sweet, chloroform-like odor, often used as a paint remover." [UM-BBD_pathwayID:dcm]
subset: gosubset_prok
synonym: "dichloromethane metabolism" EXACT []
xref: UM-BBD_pathwayID:dcm
is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process

[Term]
id: GO:0018901
name: 2,4-dichlorophenoxyacetic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 2,4-dichlorophenoxyacetic acid, a chlorinated phenoxy compound which functions as a systemic herbicide and is used to control many types of broadleaf weeds." [UM-BBD_pathwayID:2\,4d]
subset: gosubset_prok
synonym: "2,4-D metabolic process" EXACT []
synonym: "2,4-D metabolism" EXACT []
synonym: "2,4-dichlorophenoxyacetic acid metabolism" EXACT []
xref: UM-BBD_pathwayID:2\,4-d
is_a: GO:0018904 ! ether metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:0018902
name: 1,3-dichloro-2-propanol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 1,3-dichloro-2-propanol (DCP), a halohydrin suspected of being carcinogenic, mutagenic and genotoxic. DCP is used as a general solvent, as an intermediate in organic synthesis and in paints, varnishes, lacquers, water colors, binders and photographic lacquers." [GOC:jl, UM-BBD_pathwayID:dcp]
subset: gosubset_prok
synonym: "1,3-dichloro-2-propanol metabolism" EXACT []
synonym: "DCP metabolic process" EXACT []
synonym: "DCP metabolism" EXACT []
xref: UM-BBD_pathwayID:dcp
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0044107 ! cellular alcohol metabolic process
is_a: GO:1902652 ! secondary alcohol metabolic process

[Term]
id: GO:0018903
name: 1,3-dichloropropene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving members of the 1,3-dichloropropene family, which includes cis- and trans-1,3-dichloropropene. The 1,3-dichloropropenes are chlorinated hydrocarbons and the major active ingredients of commercial products for control of plant-parasitic nematodes." [UM-BBD_pathwayID:cpr]
subset: gosubset_prok
synonym: "1,3-dichloropropene metabolism" EXACT []
synonym: "1,3-dichloropropylene metabolic process" EXACT []
synonym: "1,3-dichloropropylene metabolism" EXACT []
synonym: "gamma-chloroallylchloride metabolic process" EXACT []
synonym: "gamma-chloroallylchloride metabolism" EXACT []
xref: UM-BBD_pathwayID:cpr
is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process

[Term]
id: GO:0018904
name: ether metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving organic ethers, any anhydride of the general formula R1-O-R2, formed between two identical or nonidentical organic hydroxy compounds." [GOC:pr, ISBN:0198506732]
subset: gosubset_prok
synonym: "ether metabolism" EXACT []
synonym: "organic ether metabolic process" EXACT []
synonym: "organic ether metabolism" EXACT []
is_a: GO:0044281 ! small molecule metabolic process
is_a: GO:0071704 ! organic substance metabolic process

[Term]
id: GO:0018905
name: dimethyl ether metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dimethyl ether, CH3-O-CH3, the simplest ether. Dimethyl ether, also known wood ether and methyl ether, is a colorless gas that has been used in refrigeration applications." [UM-BBD_pathwayID:dme]
subset: gosubset_prok
synonym: "dimethyl ether metabolism" EXACT []
synonym: "methyl ether metabolic process" EXACT []
synonym: "methyl ether metabolism" EXACT []
xref: UM-BBD_pathwayID:dme
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0018904 ! ether metabolic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0018906
name: methyl tert-butyl ether metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving methyl tert-butyl ether, 2-methoxy-2-methylpropane. Methyl tert-butyl ether is a synthetic chemical which is mixed with gasoline for use in reformulated gasoline. It was first introduced as an additive for unleaded gasoline in the 1980s. It is also used as a laboratory reagent and a pharmaceutical agent." [UM-BBD_pathwayID:mtb]
subset: gosubset_prok
synonym: "methyl tert-butyl ether metabolism" EXACT []
xref: UM-BBD_pathwayID:mtb
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0018904 ! ether metabolic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0018907
name: dimethyl sulfoxide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dimethyl sulfoxide, DMSO (C2H6OS), an alkyl sulfoxide that is practically odorless in its purified form. As a highly polar organic liquid, it is a powerful solvent. Its biological activities include the ability to penetrate plant and animal tissues and to preserve living cells during freezing." [CHEBI:28262, GOC:curators]
subset: gosubset_prok
synonym: "dimethyl sulfoxide metabolism" EXACT []
synonym: "dimethyl sulphoxide metabolic process" EXACT []
synonym: "dimethyl sulphoxide metabolism" EXACT []
synonym: "DMSO metabolic process" EXACT []
synonym: "DMSO metabolism" EXACT []
xref: UM-BBD_pathwayID:sulf
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0044710 ! single-organism metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0071704 ! organic substance metabolic process

[Term]
id: GO:0018908
name: organosulfide cycle
namespace: biological_process
def: "A cyclic series of interconversions involving dimethyl sulfide, methanethiol and hydrogen sulfide. Dimethylsulfoxide can also be converted to dimethyl sulfide, which enters the cycle." [UM-BBD_pathwayID:sulf]
subset: gosubset_prok
synonym: "organosulphide cycle" EXACT []
xref: UM-BBD_pathwayID:sulf
is_a: GO:0006790 ! sulfur compound metabolic process

[Term]
id: GO:0018909
name: dodecyl sulfate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dodecyl sulfate, commonly found as sodium dodecyl sulfate (SDS), a component of a variety of synthetic surfactants." [UM-BBD_pathwayID:dds]
subset: gosubset_prok
synonym: "dodecyl sulfate metabolism" EXACT []
synonym: "dodecyl sulphate metabolic process" EXACT []
synonym: "dodecyl sulphate metabolism" EXACT []
xref: UM-BBD_pathwayID:dds
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0043436 ! oxoacid metabolic process

[Term]
id: GO:0018910
name: benzene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving benzene, C6H6, a volatile, very inflammable liquid, contained in the naphtha produced by the destructive distillation of coal, from which it is separated by fractional distillation." [CHEBI:16716, GOC:ai]
subset: gosubset_prok
synonym: "benzene metabolism" EXACT []
xref: Reactome:REACT_105726 "Benzene is hydroxylated to phenol, Taeniopygia guttata"
xref: Reactome:REACT_108050 "Benzene is hydroxylated to phenol, Gallus gallus"
xref: Reactome:REACT_108912 "Benzene is hydroxylated to phenol, Canis familiaris"
xref: Reactome:REACT_228 "Benzene is hydroxylated to phenol, Homo sapiens"
xref: Reactome:REACT_31871 "Benzene is hydroxylated to phenol, Sus scrofa"
xref: Reactome:REACT_34271 "Benzene is hydroxylated to phenol, Mus musculus"
xref: Reactome:REACT_79814 "Benzene is hydroxylated to phenol, Rattus norvegicus"
xref: Reactome:REACT_89077 "Benzene is hydroxylated to phenol, Bos taurus"
xref: Reactome:REACT_97732 "Benzene is hydroxylated to phenol, Danio rerio"
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:0018911
name: 1,2,4-trichlorobenzene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 1,2,4-trichlorobenzene, a derivative of benzene with chlorine atoms attached to positions 1, 2 and 4 of the ring. It is a colorless liquid used as a solvent in chemical manufacturing, in dyes and intermediates, dielectric fluid, synthetic transformer oils, lubricants, heat-transfer medium and insecticides." [http://www.speclab.com/compound/c120821.htm]
subset: gosubset_prok
synonym: "1,2,4-trichlorobenzene metabolism" EXACT []
xref: UM-BBD_pathwayID:tbz
is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:0018912
name: 1,4-dichlorobenzene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 1,4-dichlorobenzene (p-dichlorobenzene or paramoth), a derivative of benzene with two chlorine atoms attached at opposite positions on the ring. It forms white crystals at room temperature and is used as an insecticidal fumigant, particularly in mothballs." [http://www.speclab.com/compound/c106467.htm]
subset: gosubset_prok
synonym: "1,4-dichlorobenzene metabolism" EXACT []
xref: UM-BBD_pathwayID:dcz
is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:0018913
name: anaerobic ethylbenzene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ethylbenzene (phenylethane), a benzene derivative with an ethyl group attached to the ring, that occur in the absence of oxygen." [GOC:ai]
subset: gosubset_prok
synonym: "anaerobic ethylbenzene metabolism" EXACT []
xref: UM-BBD_pathwayID:ethb
is_a: GO:0018915 ! ethylbenzene metabolic process

[Term]
id: GO:0018914
name: chlorobenzene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving chlorobenzene, a derivative of benzene with a chlorine atoms attached to the ring. It is a colorless liquid that is manufactured for use as a solvent. It quickly evaporates in the air and is degraded by hydroxyl radicals that are produced photochemically. The gas acts as a source of ClOx, which helps in the breakdown of stratospheric ozone." [http://www.shsu.edu/]
subset: gosubset_prok
synonym: "chlorobenzene metabolism" EXACT []
xref: UM-BBD_pathwayID:cb
is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:0018915
name: ethylbenzene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ethylbenzene (phenylethane), a benzene derivative with an ethyl group attached to the ring. It is a colorless liquid with a pungent odor used as a solvent and as a component of automotive and aviation fuels." [http://www.speclab.com/compound/c100414.htm]
subset: gosubset_prok
synonym: "ethylbenzene metabolism" EXACT []
xref: UM-BBD_pathwayID:ethb2
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:0018916
name: nitrobenzene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nitrobenzene (nitrobenzol), a derivative of benzene with an NO2 group attached to the ring. It is a yellow aromatic liquid used in perfumery and manufactured in large quantities in the preparation of aniline." [CHEBI:27798, GOC:curators]
subset: gosubset_prok
synonym: "nitrobenzene metabolism" EXACT []
xref: UM-BBD_pathwayID:nb
is_a: GO:0006807 ! nitrogen compound metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:0018917
name: fluorene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fluorene, a tricyclic polycyclic aromatic hydrocarbon containing a five-membered ring. It is a major component of fossil fuels and their derivatives and is also a by-product of coal-conversion and energy-related industries. It is commonly found in vehicle exhaust emissions, crude oils, motor oils, coal and oil combustion products, waste incineration, and industrial effluents." [UM-BBD_pathwayID:flu]
subset: gosubset_prok
synonym: "fluorene metabolism" EXACT []
xref: UM-BBD_pathwayID:flu
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process

[Term]
id: GO:0018918
name: gallate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving gallate, the anion of gallic acid (3,4,5-trihydroxybenzoic acid). The esters and polyesters are widely distributed in angiosperms." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "gallate metabolism" EXACT []
synonym: "gallic acid metabolic process" EXACT []
synonym: "gallic acid metabolism" EXACT []
xref: UM-BBD_pathwayID:gal
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:0018919
name: gamma-1,2,3,4,5,6-hexachlorocyclohexane metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving gamma-1,2,3,4,5,6-hexachlorocyclohexane (also known as Lindane), the most common form of hexachlorohexane, a halogenated organic insecticide that has been used worldwide for agriculture and public health." [UM-BBD_pathwayID:ghch]
subset: gosubset_prok
synonym: "gamma-1,2,3,4,5,6-hexachlorocyclohexane metabolism" EXACT []
xref: MetaCyc:GAMMAHEXCHLORDEG-PWY
xref: UM-BBD_pathwayID:ghch
is_a: GO:0019497 ! hexachlorocyclohexane metabolic process

[Term]
id: GO:0018920
name: glyphosate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glyphosate, a broad-spectrum herbicide also known by the trade name Roundup. It is a member of a broad class of compounds known as phosphonic acids, which contain a direct carbon-to-phosphorus (C-P) bond." [UM-BBD_pathwayID:gly]
subset: gosubset_prok
synonym: "glyphosate metabolism" EXACT []
synonym: "Roundup metabolic process" EXACT []
synonym: "Roundup metabolism" EXACT []
xref: UM-BBD_pathwayID:gly
is_a: GO:0006575 ! cellular modified amino acid metabolic process
is_a: GO:0006793 ! phosphorus metabolic process
is_a: GO:0043436 ! oxoacid metabolic process

[Term]
id: GO:0018921
name: 3-hydroxybenzyl alcohol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 3-hydroxybenzyl alcohol, an aromatic compound which is an intermediate in several metabolic pathways, including the biosynthesis of patulin, a toxin and antiviral agent produced by some moulds such as Penicillium patulinum." [UM-BBD_pathwayID:mcr]
subset: gosubset_prok
synonym: "3-hydroxybenzyl alcohol metabolism" EXACT []
xref: UM-BBD_pathwayID:mcr
is_a: GO:0006066 ! alcohol metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0018922
name: iprodione metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving prodione, a colorless, odorless crystal. It is used as a dicarboximide contact fungicide to control a wide variety of crop diseases by inhibiting the germination of spores and the growth of the fungal mat (mycelium)." [UM-BBD_pathwayID:ipd]
subset: gosubset_prok
synonym: "iprodione metabolism" EXACT []
xref: UM-BBD_pathwayID:ipd
is_a: GO:0042537 ! benzene-containing compound metabolic process
is_a: GO:0043603 ! cellular amide metabolic process
is_a: GO:0052803 ! imidazole-containing compound metabolic process

[Term]
id: GO:0018923
name: limonene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving limonene (4-isopropenyl-1-methyl-cyclohexene), a monocyclic monoterpene." [UM-BBD_pathwayID:lim]
subset: gosubset_prok
synonym: "limonene metabolism" EXACT []
xref: UM-BBD_pathwayID:lim
is_a: GO:0043692 ! monoterpene metabolic process

[Term]
id: GO:0018924
name: mandelate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mandelate, the anion of mandelic acid. Mandelic acid (alpha-hydroxybenzeneacetic acid) is an 8-carbon alpha-hydroxy acid (AHA) that is used in organic chemistry and as a urinary antiseptic." [GOC:jl]
subset: gosubset_prok
synonym: "mandelate metabolism" EXACT []
synonym: "mandelic acid metabolic process" EXACT []
synonym: "mandelic acid metabolism" EXACT []
xref: UM-BBD_pathwayID:mca
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process

[Term]
id: GO:0018925
name: m-cresol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving m-cresol (3-hydroxytoluene), the meta-isoform of cresol. Used to produce agricultural chemicals, and in specialty resins, pharmaceuticals and pressure-sensitive dyes." [GOC:jl]
subset: gosubset_prok
synonym: "3-hydroxytoluene metabolic process" EXACT []
synonym: "3-hydroxytoluene metabolism" EXACT []
synonym: "m-cresol metabolism" EXACT []
synonym: "meta-cresol metabolic process" EXACT []
synonym: "meta-cresol metabolism" EXACT []
xref: MetaCyc:M-CRESOL-DEGRADATION-PWY
xref: UM-BBD_pathwayID:mcr
is_a: GO:0042212 ! cresol metabolic process

[Term]
id: GO:0018926
name: methanesulfonic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving methanesulfonic acid, a strong acid produced by the oxidation of dimethyl sulfide." [UM-BBD_pathwayID:msa]
subset: gosubset_prok
synonym: "methanesulfonic acid metabolism" EXACT []
synonym: "methanesulphonic acid metabolic process" EXACT []
synonym: "methanesulphonic acid metabolism" EXACT []
xref: UM-BBD_pathwayID:msa
is_a: GO:0006082 ! organic acid metabolic process
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0019694 ! alkanesulfonate metabolic process

[Term]
id: GO:0018927
name: obsolete methionine and threonine metabolic process
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because its use of 'and' was causing violations to the true-path rule.
synonym: "methionine and threonine metabolic process" EXACT []
is_obsolete: true
consider: GO:0006555
consider: GO:0006566

[Term]
id: GO:0018928
name: methyl ethyl ketone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving methyl ethyl ketone, a clear, colorless liquid with a fragrant, mint-like odor. It is used as a solvent and in making plastics, textiles and paints." [UM-BBD_pathwayID:mek]
subset: gosubset_prok
synonym: "2-butanone metabolic process" EXACT []
synonym: "2-butanone metabolism" EXACT []
synonym: "MEK metabolic process" EXACT []
synonym: "MEK metabolism" EXACT []
synonym: "methyl ethyl ketone metabolism" EXACT []
xref: UM-BBD_pathwayID:mek
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0042180 ! cellular ketone metabolic process

[Term]
id: GO:0018929
name: methyl fluoride metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving methyl fluoride, fluorine-substituted methane, a gaseous halogenated hydrocarbon that has been investigated as an inhibitor of methanotrophy and nitrification in soils." [UM-BBD_pathwayID:mf]
subset: gosubset_prok
synonym: "methyl fluoride metabolism" EXACT []
xref: UM-BBD_pathwayID:mf
is_a: GO:0042197 ! halogenated hydrocarbon metabolic process

[Term]
id: GO:0018930
name: 3-methylquinoline metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 3-methylquinoline, C10H9N, an aromatic compound composed of a benzene ring and a heterocyclic N-containing ring." [GOC:ai]
subset: gosubset_prok
synonym: "3-methylquinoline metabolism" EXACT []
xref: UM-BBD_pathwayID:mqn
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process

[Term]
id: GO:0018931
name: naphthalene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving naphthalene, a fused ring bicyclic aromatic hydrocarbon commonly found in crude oil and oil products. Naphthalene is familiar as the compound that gives mothballs their odor; it is used in the manufacture of plastics, dyes, solvents, and other chemicals, as well as being used as an antiseptic and insecticide." [http://www.iversonsoftware.com/reference/chemistry/n/Naphthalene.htm]
subset: gosubset_prok
synonym: "naphthalene metabolism" EXACT []
xref: UM-BBD_pathwayID:naph
is_a: GO:0090420 ! naphthalene-containing compound metabolic process

[Term]
id: GO:0018933
name: nicotine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nicotine, (S)(-)-3-(1-methyl-2-pyrrolidinyl)pyridine." [GOC:sm, ISBN:0198547684]
subset: gosubset_prok
synonym: "nicotine metabolism" EXACT []
is_a: GO:0009820 ! alkaloid metabolic process
is_a: GO:0072524 ! pyridine-containing compound metabolic process

[Term]
id: GO:0018934
name: nitrilotriacetate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nitrilotriacetate, an aminotricarboxylic acid that binds bivalent metal ions in a ratio of 1:1. As an important industrial chelating agent, NTA has been widely used for various radionuclide processing and decontamination procedures, such as textile, paper and pulp processing and water treatment." [UM-BBD_pathwayID:nta]
subset: gosubset_prok
synonym: "nitrilotriacetate metabolism" EXACT []
xref: UM-BBD_pathwayID:nta
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0072350 ! tricarboxylic acid metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process

[Term]
id: GO:0018935
name: aerobic nitrilotriacetate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nitrilotriacetate, the aminotricarboxylic acid N(CH2COO-)3, that occur in the presence of oxygen." [GOC:ai]
subset: gosubset_prok
synonym: "aerobic nitrilotriacetate metabolism" EXACT []
is_a: GO:0018934 ! nitrilotriacetate metabolic process

[Term]
id: GO:0018936
name: anaerobic nitrilotriacetate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nitrilotriacetate, the aminotricarboxylic acid N(CH2COO-)3, that occur in the absence of oxygen." [GOC:ai]
subset: gosubset_prok
synonym: "anaerobic nitrilotriacetate metabolism" EXACT []
is_a: GO:0018934 ! nitrilotriacetate metabolic process

[Term]
id: GO:0018937
name: nitroglycerin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nitroglycerin, a well-known nitrate ester and an important component of dynamite and other propellants. Toxic to algae, invertebrate, and vertebrates." [UM-BBD_pathwayID:ng]
subset: gosubset_prok
synonym: "NG metabolic process" EXACT []
synonym: "NG metabolism" EXACT []
synonym: "nitroglycerin metabolism" EXACT []
xref: MetaCyc:P201-PWY
xref: UM-BBD_pathwayID:ng
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process

[Term]
id: GO:0018938
name: 2-nitropropane metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 2-nitropropane, a clear, colorless liquid with a mild, fruity odor. 2-nitropropane is used principally as a solvent and chemical intermediate. As a solvent, it is used in inks, paints, adhesives, varnishes, polymers, and synthetic materials. It is a feedstock for the manufacture of 2-nitro-2-methyl-1-propanol and 2-amino-2-methyl-1-propanol." [UM-BBD_pathwayID:npp]
subset: gosubset_prok
synonym: "2-nitropropane metabolism" EXACT []
xref: MetaCyc:PWY-723
xref: UM-BBD_pathwayID:npp
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0034641 ! cellular nitrogen compound metabolic process

[Term]
id: GO:0018939
name: n-octane metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving n-octane, the 8 carbon straight chain alkane used in organic syntheses, calibrations, and azeotropic distillations. It is a common component of gasoline and other petroleum products and the engine fuel antiknocking properties of an isomer of n-octane are used as a comparative standard in the Octane Rating System." [UM-BBD_pathwayID:oct]
subset: gosubset_prok
synonym: "n-octane metabolism" EXACT []
xref: UM-BBD_pathwayID:oct
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0043446 ! cellular alkane metabolic process

[Term]
id: GO:0018940
name: orcinol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving orcinol (5-methyl-1,3-benzenediol), an aromatic compound derived from the fermentation of lichen, and synthesized, probably as a fungicide, by some higher plants." [GOC:jl]
subset: gosubset_prok
synonym: "orcin metabolic process" EXACT []
synonym: "orcin metabolism" EXACT []
synonym: "orcinol metabolism" EXACT []
xref: MetaCyc:P342-PWY
xref: UM-BBD_pathwayID:orc
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0072490 ! toluene-containing compound metabolic process

[Term]
id: GO:0018941
name: organomercury metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving organomercury compound, any organic compound containing a mercury atom." [ISBN:0198506732]
subset: gosubset_prok
synonym: "organomercury metabolism" EXACT []
xref: UM-BBD_pathwayID:ogm
is_a: GO:0018942 ! organometal metabolic process

[Term]
id: GO:0018942
name: organometal metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving organometals, any metal-containing organic compound, especially one in which the metal atom is linked directly to one of more carbon atoms." [ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
synonym: "organometal metabolism" EXACT []
is_a: GO:0044237 ! cellular metabolic process
is_a: GO:0071704 ! organic substance metabolic process

[Term]
id: GO:0018943
name: organotin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving organotin, an organic compound containing a tin atom." [ISBN:0198506732]
subset: gosubset_prok
synonym: "organotin metabolism" EXACT []
is_a: GO:0018942 ! organometal metabolic process

[Term]
id: GO:0018944
name: tri-n-butyltin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tri-n-butyltin, an organometallic compound composed of three butyl chains attached to a tin atom. Tri-n-butyltin is used as an antifouling agent in ship bottom paints and can be toxic to many marine organisms." [GOC:ai, UM-BBD_pathwayID:tbt]
subset: gosubset_prok
synonym: "tri-n-butyltin metabolism" EXACT []
xref: UM-BBD_pathwayID:tbt
is_a: GO:0018943 ! organotin metabolic process

[Term]
id: GO:0018945
name: organosilicon metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any organosilicon, organic compounds that contain silicon, a nonmetal element analogous to carbon." [GOC:jl]
subset: gosubset_prok
synonym: "organosilicon metabolism" EXACT []
synonym: "organosilicone metabolic process" EXACT []
synonym: "organosilicone metabolism" EXACT []
xref: UM-BBD_pathwayID:osi
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0071704 ! organic substance metabolic process

[Term]
id: GO:0018946
name: aerobic organosilicon metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving organosilicons, organic compounds that contain silicon, in the presence of oxygen." [GOC:jl]
subset: gosubset_prok
synonym: "aerobic organosilicon metabolism" EXACT []
synonym: "aerobic organosilicone metabolic process" EXACT []
synonym: "aerobic organosilicone metabolism" EXACT []
xref: UM-BBD_pathwayID:osi
is_a: GO:0018945 ! organosilicon metabolic process

[Term]
id: GO:0018947
name: anaerobic organosilicon metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving organosilicons, organic compounds that contain silicon, in the absence of oxygen." [GOC:jl]
subset: gosubset_prok
synonym: "anaerobic organosilicon metabolism" EXACT []
synonym: "anaerobic organosilicone metabolic process" EXACT []
synonym: "anaerobic organosilicone metabolism" EXACT []
xref: UM-BBD_pathwayID:osi
is_a: GO:0018945 ! organosilicon metabolic process

[Term]
id: GO:0018948
name: xylene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving xylene, a mixture of three colorless, aromatic hydrocarbon liquids, ortho-, meta- and para-xylene." [GOC:jl]
subset: gosubset_prok
synonym: "xylene metabolism" EXACT []
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:0018949
name: m-xylene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving m-xylene, (1,3-dimethylbenzene) a colorless, liquid aromatic hydrocarbon." [GOC:jl]
subset: gosubset_prok
synonym: "m-xylene metabolism" EXACT []
synonym: "meta-xylene metabolic process" EXACT []
synonym: "meta-xylene metabolism" EXACT []
xref: UM-BBD_pathwayID:mxy
is_a: GO:0018948 ! xylene metabolic process

[Term]
id: GO:0018950
name: o-xylene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving o-xylene, (1,2-dimethylbenzene) a colorless, liquid aromatic hydrocarbon." [GOC:jl]
subset: gosubset_prok
synonym: "o-xylene metabolism" EXACT []
synonym: "ortho-xylene metabolic process" EXACT []
synonym: "ortho-xylene metabolism" EXACT []
xref: UM-BBD_pathwayID:oxy
is_a: GO:0018948 ! xylene metabolic process

[Term]
id: GO:0018951
name: p-xylene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving p-xylene, (1,4-dimethylbenzene) a colorless, liquid aromatic hydrocarbon." [GOC:jl]
subset: gosubset_prok
synonym: "p-xylene metabolism" EXACT []
synonym: "para-xylene metabolic process" EXACT []
synonym: "para-xylene metabolism" EXACT []
xref: UM-BBD_pathwayID:pxy
is_a: GO:0018948 ! xylene metabolic process

[Term]
id: GO:0018952
name: parathion metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving parathion, a highly toxic organophosphate compound formerly used as a broad spectrum insecticide, acaricide, fumigant and nematocide. Degradation of parathion by sunlight or liver enzymes can result in the formation of the active compound paraoxon which interferes with the nervous system through cholinesterase inhibition." [UM-BBD_pathwayID:pthn]
subset: gosubset_prok
synonym: "parathion metabolism" EXACT []
xref: UM-BBD_pathwayID:pthn
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0006807 ! nitrogen compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process

[Term]
id: GO:0018953
name: p-cymene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving p-cymene, 1-methyl-4-isopropylbenzene, one of the alkyl-substituted aromatic hydrocarbons found in volatile oils from over 100 plants." [UM-BBD_pathwayID:pcy]
subset: gosubset_prok
synonym: "p-cymene metabolism" EXACT []
xref: UM-BBD_pathwayID:pcy
is_a: GO:0043692 ! monoterpene metabolic process
is_a: GO:0072490 ! toluene-containing compound metabolic process

[Term]
id: GO:0018954
name: pentaerythritol tetranitrate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pentaerythritol tetranitrate, C(CH2-O-NO2)4, a substance produced for use as an explosive and a vasodilator." [UM-BBD_pathwayID:petn]
subset: gosubset_prok
synonym: "pentaerythritol tetranitrate metabolism" EXACT []
xref: UM-BBD_pathwayID:petn
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process

[Term]
id: GO:0018955
name: phenanthrene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phenanthrene, a tricyclic aromatic hydrocarbon used in explosives and in the synthesis of dyes and drugs. Although phenanthrene is not mutagenic or carcinogenic, it has been shown to be toxic to marine diatoms, gastropods, mussels, crustaceans, and fish." [GOC:jl, UM-BBD_pathwayID:pha]
subset: gosubset_prok
synonym: "phenanthrene metabolism" EXACT []
xref: UM-BBD_pathwayID:pha
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process

[Term]
id: GO:0018956
name: phenanthrene catabolic process via trans-9(R),10(R)-dihydrodiolphenanthrene
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phenanthrene, a tricyclic aromatic hydrocarbon, where trans-9(R),10(R)-dihydrodiolphenanthrene is the principal intermediate metabolite." [UM-BBD_pathwayID:pha3]
subset: gosubset_prok
synonym: "phenanthrene breakdown via trans-9(R),10(R)-dihydrodiolphenanthrene" EXACT []
synonym: "phenanthrene degradation via trans-9(R),10(R)-dihydrodiolphenanthrene" EXACT []
xref: UM-BBD_pathwayID:pha3
is_a: GO:0042216 ! phenanthrene catabolic process

[Term]
id: GO:0018957
name: phenanthrene catabolic process via trans-9(S),10(S)-dihydrodiolphenanthrene
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phenanthrene, a tricyclic aromatic hydrocarbon, where trans-9(S),10(S)-dihydrodiolphenanthrene is the principal intermediate metabolite." [UM-BBD_pathwayID:pha2]
subset: gosubset_prok
synonym: "phenanthrene breakdown via trans-9(S),10(S)-dihydrodiolphenanthrene" EXACT []
synonym: "phenanthrene degradation via trans-9(S),10(S)-dihydrodiolphenanthrene" EXACT []
xref: UM-BBD_pathwayID:pha2
is_a: GO:0042216 ! phenanthrene catabolic process

[Term]
id: GO:0018958
name: phenol-containing compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring." [CHEBI:33853, ISBN:0198506732]
comment: Note that phenol metabolism is not included as a child of 'xenobiotic metabolism' because although it is synthesized industrially, phenol is also found naturally in animal wastes and other organic materials. It is often formed by the activity of microorganisms, which can chemically modify a variety of xenobiotic and naturally occurring phenolic compounds.
subset: gosubset_prok
synonym: "carbolic acid metabolic process" EXACT []
synonym: "carbolic acid metabolism" EXACT []
synonym: "hydroxybenzene metabolic process" EXACT []
synonym: "hydroxybenzene metabolism" EXACT []
synonym: "phenol-containing compound metabolism" EXACT [GOC:curators]
xref: UM-BBD_pathwayID:phe
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process

[Term]
id: GO:0018959
name: aerobic phenol-containing compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the presence of oxygen." [CHEBI:33853, ISBN:0198506732]
subset: gosubset_prok
synonym: "aerobic phenol-containing compound metabolism" EXACT [GOC:curators]
xref: UM-BBD_pathwayID:pba
is_a: GO:0018958 ! phenol-containing compound metabolic process

[Term]
id: GO:0018960
name: 4-nitrophenol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 4-nitrophenol, a nitroaromatic compound which is used in the production of dyes, leather treatment agents, fungicides and as an intermediate in the production of the insecticide parathion." [GOC:jl]
subset: gosubset_prok
synonym: "4-nitrophenol metabolism" EXACT []
synonym: "p-nitrophenol metabolic process" EXACT []
synonym: "p-nitrophenol metabolism" EXACT []
xref: UM-BBD_pathwayID:nphe
is_a: GO:0006807 ! nitrogen compound metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process

[Term]
id: GO:0018961
name: pentachlorophenol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pentachlorophenol, a chlorinated insecticide and fungicide used primarily to protect timber from fungal rot and wood boring insects. Pentachlorophenol is significantly toxic to mammals, plants, and many microorganisms." [UM-BBD_pathwayID:pcp]
subset: gosubset_prok
synonym: "PCP metabolic process" EXACT []
synonym: "PCP metabolism" EXACT []
synonym: "pentachlorophenol metabolism" EXACT []
xref: UM-BBD_pathwayID:pcp
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:0018962
name: 3-phenylpropionate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 3-phenylpropionate, the anion of phenylpropanoic acid. It is produced from putrefaction of proteins in soil or breakdown of several constituents of plants, such as lignin, various oils and resins." [GOC:ai, UM-BBD_pathwayID:ppa]
subset: gosubset_prok
synonym: "3-phenylpropionate metabolism" EXACT []
synonym: "hydrocinnamic acid metabolic process" EXACT []
synonym: "hydrocinnamic acid metabolism" EXACT []
synonym: "phenylpropanoate metabolic process" EXACT []
synonym: "phenylpropanoate metabolism" EXACT []
xref: UM-BBD_pathwayID:ppa
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:0018963
name: phthalate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phthalate, the anion of phthalic acid. Phthalic acid diesters are used industrially in the production of a variety of household and consumer goods including plastic polymers, lubricating oils, and carriers for perfumes in cosmetics, while phthalic acid itself is used industrially as a plasticizer. Terephthalate is used in the synthesis of polyethylene terephthalate (polyethene terephthlate, abbreviated PET or PETE), a plastic polymer with many commercial uses." [UM-BBD_pathwayID:pth]
subset: gosubset_prok
synonym: "phthalate metabolism" EXACT []
synonym: "phthalic acid metabolic process" EXACT []
synonym: "phthalic acid metabolism" EXACT []
xref: UM-BBD_pathwayID:pth
is_a: GO:0042537 ! benzene-containing compound metabolic process
is_a: GO:0043648 ! dicarboxylic acid metabolic process

[Term]
id: GO:0018964
name: propylene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving propylene, an alkene produced by catalytic or thermal cracking of hydrocarbons or as a by-product of petroleum refining. It is used mainly in the preparation of alkylates for gasoline and in the production of polypropylene, acrylonitrile, propylene oxide and a number of other industrial chemicals." [GOC:jl]
subset: gosubset_prok
synonym: "propylene metabolism" EXACT []
xref: UM-BBD_pathwayID:pro
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0043449 ! cellular alkene metabolic process

[Term]
id: GO:0018965
name: s-triazine compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any s-triazine compound. These compounds include many pesticides of widespread use in agriculture, and are characterized by a symmetrical hexameric ring consisting of alternating carbon and nitrogen atoms." [UM-BBD_pathwayID:tria]
subset: gosubset_prok
synonym: "s-triazine compound metabolism" EXACT []
xref: UM-BBD_pathwayID:tria
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process

[Term]
id: GO:0018966
name: styrene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving styrene, an aromatic hydrocarbon liquid soluble in ether and alcohol. When heated, exposed to light or added to a peroxide catalyst, it undergoes polymerization to form polystyrene, a versatile material used in the manufacture of plastics, synthetic rubber, thermal insulation, and packaging. Styrene is a classified mutagen and a suspected carcinogen." [GOC:jl, UM-BBD_pathwayID:sty]
subset: gosubset_prok
synonym: "styrene metabolism" EXACT []
xref: UM-BBD_pathwayID:sty
is_a: GO:0042537 ! benzene-containing compound metabolic process
is_a: GO:1900673 ! olefin metabolic process

[Term]
id: GO:0018967
name: tetrachloroethylene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tetrachloroethylene (tetrachloroethene), a derivative of ethene with the hydrogen atoms replaced by chlorines. Tetrachloroethene has been used primarily as a solvent in dry-cleaning industries and to a lesser extent as a degreasing solvent." [http://www.who.int/water_sanitation_health/GDWQ/Chemicals/tetrachloroethenesum.htm]
subset: gosubset_prok
synonym: "tetrachloroethene metabolic process" EXACT []
synonym: "tetrachloroethene metabolism" EXACT []
synonym: "tetrachloroethylene metabolism" EXACT []
xref: UM-BBD_pathwayID:tce2
is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process

[Term]
id: GO:0018968
name: tetrahydrofuran metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tetrahydrofuran, a cyclic 4 carbon ether. It is one of the most polar ethers and is a widely used solvent for polar reagents. Since THF is very soluble in water and has a relatively low boiling point, significant amounts are often released into the environment, causing contamination problems." [UM-BBD_pathwayID:thf]
subset: gosubset_prok
synonym: "tetrahydrofuran metabolism" EXACT []
synonym: "THF metabolic process" EXACT []
synonym: "THF metabolism" EXACT []
xref: UM-BBD_pathwayID:thf
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0097176 ! epoxide metabolic process

[Term]
id: GO:0018969
name: thiocyanate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving thiocyanate, the anion of thiocyanic acid, a toxic cyanide derivative commonly formed as a by-product in the production of gas for fuel, coke, and substances for chemical industries." [GOC:jl]
subset: gosubset_prok
synonym: "thiocyanate metabolism" EXACT []
synonym: "thiocyanic acid metabolic process" EXACT []
synonym: "thiocyanic acid metabolism" EXACT []
xref: MetaCyc:P581-PWY
xref: UM-BBD_pathwayID:thc
is_a: GO:0006082 ! organic acid metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0006805 ! xenobiotic metabolic process

[Term]
id: GO:0018970
name: toluene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products such as gasoline and commonly used as a paint thinning agent and in other solvent applications." [UM-BBD_pathwayID:tol]
subset: gosubset_prok
synonym: "methylbenzene metabolic process" EXACT []
synonym: "methylbenzene metabolism" EXACT []
synonym: "toluene metabolism" EXACT []
is_a: GO:0072490 ! toluene-containing compound metabolic process

[Term]
id: GO:0018971
name: anaerobic toluene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products, that occur in the absence of oxygen." [GOC:ai]
subset: gosubset_prok
synonym: "anaerobic toluene metabolism" EXACT []
xref: UM-BBD_pathwayID:tol2
is_a: GO:0018970 ! toluene metabolic process

[Term]
id: GO:0018972
name: toluene-4-sulfonate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving toluene-4-sulfonate, the anion of 4-toluene sulfonic acid, a white crystalline solid which is highly hygroscopic and soluble in water." [GOC:ai]
subset: gosubset_prok
synonym: "4-methylbenzenesulfonate metabolic process" EXACT []
synonym: "4-methylbenzenesulfonate metabolism" EXACT []
synonym: "4-toluenesulfonate metabolic process" EXACT []
synonym: "4-toluenesulfonate metabolism" EXACT []
synonym: "toluene-4-sulfonate metabolism" EXACT []
synonym: "toluene-4-sulphonate metabolic process" EXACT []
synonym: "toluene-4-sulphonate metabolism" EXACT []
xref: MetaCyc:TOLSULFDEG-PWY
xref: UM-BBD_pathwayID:tsa
is_a: GO:0006082 ! organic acid metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0072490 ! toluene-containing compound metabolic process

[Term]
id: GO:0018973
name: trinitrotoluene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving trinitrotoluene, a methylated benzene molecule with three NO2 groups attached to it. This includes the explosive TNT, 1-methyl-2,4,6-trinitrobenzene." [GOC:ai]
subset: gosubset_prok
synonym: "trinitrotoluene metabolism" EXACT []
xref: UM-BBD_pathwayID:tnt
is_a: GO:0019326 ! nitrotoluene metabolic process

[Term]
id: GO:0018974
name: 2,4,6-trinitrotoluene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid. It is prepared from toluene treated with concentrated sulfuric and nitric acids and is used in shells, bombs, and blasting explosives." [ISBN:0333781767]
subset: gosubset_prok
synonym: "2,4,6-trinitrotoluene metabolism" EXACT []
synonym: "TNT metabolic process" EXACT []
synonym: "TNT metabolism" EXACT []
is_a: GO:0018973 ! trinitrotoluene metabolic process

[Term]
id: GO:0018975
name: anaerobic 2,4,6-trinitrotoluene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid, that occur in the absence of oxygen." [GOC:ai]
subset: gosubset_prok
synonym: "anaerobic 2,4,6-trinitrotoluene metabolism" EXACT []
xref: UM-BBD_pathwayID:tnt2
is_a: GO:0018974 ! 2,4,6-trinitrotoluene metabolic process
is_a: GO:0072491 ! toluene-containing compound catabolic process

[Term]
id: GO:0018976
name: 1,2,3-tribromopropane metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 1,2,3-tribromopropane, a toxic and volatile organic compound commonly used as a nematocide in agriculture." [GOC:jl]
subset: gosubset_prok
synonym: "1,2,3-tribromopropane metabolism" EXACT []
xref: UM-BBD_pathwayID:tbp
is_a: GO:0042197 ! halogenated hydrocarbon metabolic process

[Term]
id: GO:0018977
name: 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane (DDT), a chlorinated broad spectrum contact insecticide." [GOC:jl]
subset: gosubset_prok
synonym: "1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolism" EXACT []
synonym: "DDT metabolic process" EXACT []
synonym: "DDT metabolism" EXACT []
xref: UM-BBD_pathwayID:ddt
is_a: GO:0017143 ! insecticide metabolic process
is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:0018978
name: anaerobic 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane (DDT), a chlorinated, broad spectrum, contact insecticide, in the absence of oxygen." [GOC:jl]
subset: gosubset_prok
synonym: "anaerobic 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolism" EXACT []
synonym: "anaerobic DDT metabolic process" EXACT []
synonym: "anaerobic DDT metabolism" EXACT []
xref: UM-BBD_pathwayID:ddt2
is_a: GO:0018977 ! 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolic process

[Term]
id: GO:0018979
name: trichloroethylene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving trichloroethylene, a toxic, colorless, photoreactive, chlorinated hydrocarbon liquid, commonly used as a metal degreaser and solvent." [GOC:jl]
subset: gosubset_prok
synonym: "TCE metabolic process" EXACT []
synonym: "TCE metabolism" EXACT []
synonym: "trichloroethene metabolic process" EXACT []
synonym: "trichloroethene metabolism" EXACT []
synonym: "trichloroethylene metabolism" EXACT []
xref: UM-BBD_pathwayID:tce
is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process

[Term]
id: GO:0018980
name: 2,4,5-trichlorophenoxyacetic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 2,4,5-trichlorophenoxyacetic acid, a chlorinated aromatic compound which is widely used as a herbicide, often as a weed killer for home lawns." [UM-BBD_pathwayID:2\,4\,5-t]
subset: gosubset_prok
synonym: "2,4,5-T metabolic process" EXACT []
synonym: "2,4,5-T metabolism" EXACT []
synonym: "2,4,5-trichlorophenoxyacetic acid metabolism" EXACT []
xref: UM-BBD_pathwayID:2\,4\,5-t
is_a: GO:0018904 ! ether metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:0018981
name: triethanolamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving triethanolamine, a combustible, hygroscopic, colorless liquid commonly used in dry-cleaning solutions, cosmetics, detergents, textile processing, wool scouring, and as a corrosion inhibitor and pharmaceutical alkalizing agent." [GOC:jl]
subset: gosubset_prok
synonym: "triethanolamine metabolism" EXACT []
xref: UM-BBD_pathwayID:tea
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0044106 ! cellular amine metabolic process
is_a: GO:0044107 ! cellular alcohol metabolic process

[Term]
id: GO:0018982
name: vanillin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving vanillin, an aromatic hydrocarbon which occurs naturally in black vanilla bean pods and can be obtained as a by-product of the pulp and paper industry by the oxidative breakdown of lignin." [GOC:jl]
subset: gosubset_prok
synonym: "vanillic aldehyde metabolic process" EXACT []
synonym: "vanillic aldehyde metabolism" EXACT []
synonym: "vanillin metabolism" EXACT []
xref: UM-BBD_pathwayID:van
is_a: GO:0006081 ! cellular aldehyde metabolic process
is_a: GO:0018904 ! ether metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:0018983
name: Z-phenylacetaldoxime metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving Z-phenylacetaldoxime, a member of the glucosinolate group of compounds, a class of natural products that are gaining increasing interest as cancer-preventing agents and crop protectants." [UM-BBD_pathwayID:car]
subset: gosubset_prok
synonym: "Z-phenylacetaldoxime metabolism" EXACT []
xref: UM-BBD_pathwayID:pao
is_a: GO:0019330 ! aldoxime metabolic process

[Term]
id: GO:0018984
name: naphthalenesulfonate metabolic process
namespace: biological_process
alt_id: GO:0018932
def: "The chemical reactions and pathways involving naphthalenesulfonate, sulfonated derivatives of naphthalene." [GOC:ai]
subset: gosubset_prok
synonym: "naphthalenesulfonate metabolism" EXACT []
synonym: "naphthalenesulphonate metabolic process" EXACT []
synonym: "naphthalenesulphonate metabolism" EXACT []
xref: UM-BBD_pathwayID:nphs
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0090420 ! naphthalene-containing compound metabolic process

[Term]
id: GO:0018985
name: pronuclear envelope synthesis
namespace: biological_process
def: "Synthesis and ordering of the envelope of pronuclei." [GOC:ems]
is_a: GO:0006998 ! nuclear envelope organization
is_a: GO:0044702 ! single organism reproductive process
relationship: part_of GO:0007338 ! single fertilization

[Term]
id: GO:0018988
name: obsolete molting cycle, protein-based cuticle
namespace: biological_process
def: "OBSOLETE. The periodic shedding of part or all of a protein-based cuticle, which is then replaced by a new protein-based cuticle. A cuticle is the outer layer of an animal which acts to prevent water loss." [GOC:ems, GOC:mtg_sensu]
comment: This term was made obsolete because 'protein-based cuticle' is an unnecessary grouping term.
synonym: "protein-based cuticle molting cycle" EXACT [GOC:dph, GOC:tb]
is_obsolete: true
consider: GO:0007591
consider: GO:0018996

[Term]
id: GO:0018989
name: apolysis
namespace: biological_process
def: "The first process of molting, characterized by the detachment of the old cuticle from the underlying epidermal cells." [GOC:jl]
xref: Wikipedia:Apolysis
is_a: GO:0022404 ! molting cycle process
relationship: part_of GO:0007591 ! molting cycle, chitin-based cuticle

[Term]
id: GO:0018990
name: ecdysis, chitin-based cuticle
namespace: biological_process
def: "The shedding of the old chitin-based cuticlar fragments during the molting cycle. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
is_a: GO:0022404 ! molting cycle process
relationship: part_of GO:0007591 ! molting cycle, chitin-based cuticle

[Term]
id: GO:0018991
name: oviposition
namespace: biological_process
def: "The deposition of eggs (either fertilized or not) upon a surface or into a medium such as water." [GOC:ems]
synonym: "egg laying" BROAD []
synonym: "egg-laying" BROAD []
xref: Wikipedia:Oviposition
is_a: GO:0019098 ! reproductive behavior

[Term]
id: GO:0018992
name: germ-line sex determination
namespace: biological_process
def: "The determination of sex and sexual phenotype in an organism's germ line." [GOC:ems]
is_a: GO:0007530 ! sex determination
relationship: part_of GO:0007275 ! multicellular organism development

[Term]
id: GO:0018993
name: somatic sex determination
namespace: biological_process
def: "The determination of sex and sexual phenotypes in an organism's soma." [GOC:ems]
is_a: GO:0007530 ! sex determination
relationship: part_of GO:0007275 ! multicellular organism development

[Term]
id: GO:0018995
name: host
namespace: cellular_component
def: "Any organism in which another organism, especially a parasite or symbiont, spends part or all of its life cycle and from which it obtains nourishment and/or protection." [ISBN:0198506732]
subset: gosubset_prok
synonym: "host organism" EXACT []
xref: Wikipedia:Host_(biology)
is_a: GO:0044215 ! other organism

[Term]
id: GO:0018996
name: molting cycle, collagen and cuticulin-based cuticle
namespace: biological_process
def: "The periodic shedding of part or all of a collagen and cuticulin-based cuticle, which is then replaced by a new collagen and cuticulin-based cuticle. An example of this is found in the Nematode worm, Caenorhabditis elegans." [GOC:jl, GOC:mtg_sensu]
synonym: "collagen and cuticulin-based cuticle molting cycle" EXACT [GOC:dph, GOC:tb]
is_a: GO:0042303 ! molting cycle

[Term]
id: GO:0018997
name: obsolete electron transfer carrier
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because the parent terms cover its function.
synonym: "electron transfer carrier" EXACT []
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0018998
name: obsolete metaxin
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "metaxin" EXACT []
is_obsolete: true
consider: GO:0005741

[Term]
id: GO:0019000
name: obsolete endonuclease G activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [PMID:12444964, PMID:12928502, PMID:12941691]
comment: This term was made obsolete because it represents a gene product.
synonym: "endonuclease G activity" EXACT []
is_obsolete: true
consider: GO:0004520
consider: GO:0004521

[Term]
id: GO:0019001
name: guanyl nucleotide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate." [ISBN:0198506732]
subset: gosubset_prok
xref: Reactome:REACT_102579 "eEF1A complexes with GTP, Dictyostelium discoideum"
xref: Reactome:REACT_106634 "eEF1A complexes with GTP, Saccharomyces cerevisiae"
xref: Reactome:REACT_108817 "eEF1A complexes with GTP, Mus musculus"
xref: Reactome:REACT_145 "reEF1A complexes with GTP, Oryctolagus cuniculus"
xref: Reactome:REACT_31933 "eEF1A complexes with GTP, Danio rerio"
xref: Reactome:REACT_80017 "eEF1A complexes with GTP, Canis familiaris"
xref: Reactome:REACT_86336 "eEF1A complexes with GTP, Bos taurus"
xref: Reactome:REACT_87166 "eEF1A complexes with GTP, Plasmodium falciparum"
xref: Reactome:REACT_88634 "eEF1A complexes with GTP, Schizosaccharomyces pombe"
xref: Reactome:REACT_90 "eEF1A complexes with GTP, Homo sapiens"
xref: Reactome:REACT_95879 "eEF1A complexes with GTP, Gallus gallus"
xref: Reactome:REACT_97634 "eEF1A complexes with GTP, Drosophila melanogaster"
is_a: GO:0017076 ! purine nucleotide binding

[Term]
id: GO:0019002
name: GMP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with GMP, guanosine monophosphate." [GOC:ai]
is_a: GO:0032550 ! purine ribonucleoside binding
is_a: GO:0032561 ! guanyl ribonucleotide binding
is_a: GO:0043168 ! anion binding

[Term]
id: GO:0019003
name: GDP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with GDP, guanosine 5'-diphosphate." [GOC:ai]
is_a: GO:0032550 ! purine ribonucleoside binding
is_a: GO:0032561 ! guanyl ribonucleotide binding
is_a: GO:0043168 ! anion binding

[Term]
id: GO:0019005
name: SCF ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]
synonym: "CDL1 complex" EXACT []
synonym: "CRL1 complex" EXACT []
synonym: "Cul1-RING ubiquitin ligase complex" EXACT []
synonym: "cullin-RING ligase 1" EXACT []
synonym: "SCF complex" EXACT []
synonym: "SCF complex substrate recognition subunit" NARROW []
synonym: "Skp1/Cul1/F-box protein complex" EXACT []
xref: Wikipedia:SCF_complex
is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex

[Term]
id: GO:0019008
name: molybdopterin synthase complex
namespace: cellular_component
alt_id: GO:0019009
def: "A protein complex that possesses molybdopterin synthase activity. In E. coli, the complex is a heterotetramer consisting of two MoaD and two MoaE subunits." [GOC:mah, PMID:12571227, PMID:15709772]
subset: gosubset_prok
synonym: "molybdopterin converting factor complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0019010
name: farnesoic acid O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: farnesoic acid + S-adenosyl-methionine = methyl farnesoate + S-adenosyl-L-homocysteine." [PMID:12135499]
synonym: "S-adenosyl-methionine:farnesoic acid O-methyltransferase activity" EXACT []
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0019011
name: obsolete DNA replication accessory factor
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it does not represent a true molecular function.
synonym: "DNA replication accessory factor" EXACT []
is_obsolete: true
consider: GO:0006260

[Term]
id: GO:0019012
name: virion
namespace: cellular_component
def: "The complete fully infectious extracellular virus particle." [ISBN:0781718325]
subset: goslim_chembl
subset: goslim_metagenomics
subset: goslim_pir
synonym: "complete virus particle" EXACT []
xref: Wikipedia:Virus
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0019013
name: viral nucleocapsid
namespace: cellular_component
alt_id: GO:0019014
def: "The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534]
subset: goslim_chembl
synonym: "core" BROAD []
synonym: "nucleocapsid" EXACT []
is_a: GO:0044423 ! virion part
relationship: part_of GO:0019028 ! viral capsid

[Term]
id: GO:0019015
name: viral genome
namespace: cellular_component
def: "The whole of the genetic information of a virus, contained as either DNA or RNA." [ISBN:0198506732]
is_a: GO:0044423 ! virion part

[Term]
id: GO:0019016
name: non-segmented viral genome
namespace: cellular_component
def: "A viral genome that consists of one continuous nucleic acid molecule." [GOC:pk]
is_a: GO:0019015 ! viral genome

[Term]
id: GO:0019017
name: segmented viral genome
namespace: cellular_component
def: "A viral genome that is divided into two or more physically separate molecules of nucleic acid and packaged into a single virion." [ISBN:0121585336]
is_a: GO:0019015 ! viral genome

[Term]
id: GO:0019018
name: bipartite viral genome
namespace: cellular_component
def: "A segmented viral genome consisting of two sub-genomic nucleic acids but each nucleic acid is packaged into a different virion." [ISBN:0121585336]
is_a: GO:0019017 ! segmented viral genome

[Term]
id: GO:0019019
name: tripartite viral genome
namespace: cellular_component
def: "A segmented viral genome consisting of three sub-genomic nucleic acids but each nucleic acid is packaged into a different virion." [ISBN:0121585336]
is_a: GO:0019017 ! segmented viral genome

[Term]
id: GO:0019020
name: multipartite viral genome
namespace: cellular_component
def: "A segmented viral genome consisting of more than three sub-genomic nucleic acids but each nucleic acid is packaged into a different virion." [ISBN:0121585336]
is_a: GO:0019017 ! segmented viral genome

[Term]
id: GO:0019021
name: DNA viral genome
namespace: cellular_component
def: "A viral genome composed of deoxyribonucleic acid." [ISBN:0121585336]
is_a: GO:0005694 ! chromosome
is_a: GO:0019015 ! viral genome

[Term]
id: GO:0019022
name: RNA viral genome
namespace: cellular_component
def: "A viral genome composed of ribonucleic acid. This results in genome replication and expression of genetic information being inextricably linked." [ISBN:0121585336]
is_a: GO:0019015 ! viral genome

[Term]
id: GO:0019023
name: dsRNA viral genome
namespace: cellular_component
def: "A viral genome composed of double stranded RNA." [ISBN:0121585336]
is_a: GO:0019022 ! RNA viral genome

[Term]
id: GO:0019024
name: ssRNA viral genome
namespace: cellular_component
def: "A viral genome composed of single stranded RNA of either positive or negative sense." [ISBN:0121585336]
is_a: GO:0019022 ! RNA viral genome

[Term]
id: GO:0019025
name: positive sense viral genome
namespace: cellular_component
def: "A single stranded RNA genome with the same nucleotide polarity as mRNA." [ISBN:0121585336]
is_a: GO:0019024 ! ssRNA viral genome

[Term]
id: GO:0019026
name: negative sense viral genome
namespace: cellular_component
def: "A single stranded RNA genome with the opposite nucleotide polarity as mRNA." [ISBN:0121585336]
is_a: GO:0019024 ! ssRNA viral genome

[Term]
id: GO:0019027
name: ambisense viral genome
namespace: cellular_component
def: "A RNA genome that contains coding regions that are either positive sense or negative sense on the same RNA molecule." [ISBN:0121585336]
is_a: GO:0019024 ! ssRNA viral genome

[Term]
id: GO:0019028
name: viral capsid
namespace: cellular_component
alt_id: GO:0046728
def: "The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres." [GOC:mtg_sensu, ISBN:0198506732]
subset: goslim_chembl
xref: Wikipedia:Capsid
is_a: GO:0044423 ! virion part

[Term]
id: GO:0019029
name: helical viral capsid
namespace: cellular_component
def: "The protein coat that surrounds the infective nucleic acid in some virus particles; the subunits are arranged to form a protein helix with the genetic material contained within. Tobacco mosaic virus has such a capsid structure." [ISBN:071673706X, UniProtKB-KW:KW-1139, VZ:885]
is_a: GO:0019028 ! viral capsid

[Term]
id: GO:0019030
name: icosahedral viral capsid
namespace: cellular_component
def: "The protein coat that surrounds the infective nucleic acid in some virus particles; the subunits are arranged to form an icosahedron, a solid with 20 faces and 12 vertices. Icosahedral capsids have 12 pentamers plus 10(T-1) hexamers, where T is the triangulation number. Tobacco satellite necrosis virus has such a capsid structure." [GOC:bm, ISBN:0198506732, ISBN:071673706X, VZ:885, Wikipedia:Capsid]
synonym: "quasispherical viral capsid" EXACT []
is_a: GO:0019028 ! viral capsid

[Term]
id: GO:0019031
name: viral envelope
namespace: cellular_component
def: "The lipid bilayer of a virion that surrounds the protein capsid. May also contain glycoproteins." [GOC:bf, GOC:bm, GOC:jl, ISBN:0781718325, Wikipedia:Viral_envelope]
subset: goslim_chembl
synonym: "viral glycoprotein" RELATED []
synonym: "viral outside membrane" EXACT []
xref: Wikipedia:Viral_envelope
is_a: GO:0036338 ! viral membrane

[Term]
id: GO:0019032
name: obsolete viral glycoprotein
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a type of gene product and not a location or complex.
synonym: "viral glycoprotein" EXACT []
is_obsolete: true
consider: GO:0019031

[Term]
id: GO:0019033
name: viral tegument
namespace: cellular_component
def: "A structure lying between the capsid and envelope of a virus, varying in thickness and often distributed asymmetrically." [ISBN:0721662544]
xref: Wikipedia:Viral_tegument
is_a: GO:0044423 ! virion part

[Term]
id: GO:0019034
name: viral replication complex
namespace: cellular_component
def: "Specific locations and structures in the virus infected cell involved in replicating the viral genome." [ISBN:0781718325]
is_a: GO:0044094 ! host cell nuclear part

[Term]
id: GO:0019035
name: viral integration complex
namespace: cellular_component
def: "A nucleoprotein complex containing viral genetic material and associated viral and host proteins, which is capable of inserting a viral genome into a host genome." [ISBN:0781718325, PMID:16712776, Wikipedia:Pre-integration_complex]
subset: virus_checked
synonym: "PIC" EXACT [PMID:16712776]
synonym: "pre-integration complex" EXACT [PMID:16712776]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0019036
name: viral transcriptional complex
namespace: cellular_component
def: "Specific locations and structures in the virus infected cell involved in transcribing the viral genome." [ISBN:0781718325]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0019037
name: viral assembly intermediate
namespace: cellular_component
def: "Specific locations and structures in the virus infected cell involved in assembling new virions." [ISBN:0781718325]
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0019038
name: provirus
namespace: cellular_component
def: "The name given to a viral genome after it has been integrated into the host genome; particularly applies to retroviruses and is a required part of the retroviral replication cycle." [ISBN:0121585336]
xref: Wikipedia:Provirus
is_a: GO:0019015 ! viral genome
is_a: GO:0044427 ! chromosomal part
intersection_of: GO:0019015 ! viral genome
intersection_of: part_of GO:0005694 ! chromosome
relationship: part_of GO:0005694 ! chromosome

[Term]
id: GO:0019039
name: obsolete viral-cell fusion molecule activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "viral-cell fusion molecule activity" EXACT []
is_obsolete: true
consider: GO:0019064
consider: GO:0050839

[Term]
id: GO:0019040
name: obsolete viral host shutoff protein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it does not represent a molecular function.
synonym: "viral host shutoff protein" EXACT []
is_obsolete: true
consider: GO:0004534
consider: GO:0019057

[Term]
id: GO:0019042
name: viral latency
namespace: biological_process
alt_id: GO:0030069
alt_id: GO:0075710
def: "The process by which, after initial infection, a virus lies dormant within a cell and viral production ceases. The process ends when the virus switches from latency and starts to replicate." [GOC:jl]
synonym: "latent virus infection" EXACT []
synonym: "phage lysogeny" EXACT []
synonym: "viral dormancy" EXACT []
is_a: GO:0016032 ! viral process

[Term]
id: GO:0019043
name: establishment of viral latency
namespace: biological_process
alt_id: GO:0075601
def: "A process by which a virus establishes a latent state within its host, either as an integrated provirus within the host genome or as an episome, where viral genome remains in the cytoplasm or nucleus as distinct objects." [GOC:jl]
subset: virus_checked
synonym: "lysogenic commitment" EXACT []
synonym: "phage lysogeny" NARROW []
xref: PHI:0000007
is_a: GO:0016032 ! viral process
relationship: part_of GO:0019042 ! viral latency

[Term]
id: GO:0019044
name: maintenance of viral latency
namespace: biological_process
alt_id: GO:0032360
alt_id: GO:0075716
def: "The perpetuation of a latent state, generally by repressing the viruses own lytic genes expression and ensuring expression of viral genes which function to keep the viral genome from being detected by the host defense mechanisms." [GOC:jl]
subset: virus_checked
synonym: "latent virus maintenance" EXACT []
synonym: "prophage maintenance" EXACT []
synonym: "provirus maintenance" EXACT []
is_a: GO:0016032 ! viral process
relationship: part_of GO:0019042 ! viral latency

[Term]
id: GO:0019045
name: latent virus replication
namespace: biological_process
def: "Any process required for latent viral replication in a cell." [ISBN:0781702534]
is_a: GO:0016032 ! viral process
relationship: part_of GO:0019042 ! viral latency

[Term]
id: GO:0019046
name: release from viral latency
namespace: biological_process
alt_id: GO:0075717
def: "The process by which a virus switches from latency and begins to replicate. It may be effected by various endogenous and exogenous stimuli, including B-cell lipopolysaccharides, glucocorticoid hormones, halogenated pyrimidines, ionizing radiation, ultraviolet light, various chemicals and super-infecting viruses." [GOC:jl]
synonym: "exit from viral latency" EXACT []
synonym: "lytic switch" EXACT []
synonym: "prophage induction" NARROW []
synonym: "proviral induction" EXACT []
synonym: "proviral switch" EXACT []
synonym: "reactivation of latent virus" EXACT []
synonym: "virus activation" EXACT []
xref: PHI:0000062
is_a: GO:0016032 ! viral process
relationship: part_of GO:0019042 ! viral latency

[Term]
id: GO:0019048
name: modulation by virus of host morphology or physiology
namespace: biological_process
alt_id: GO:0044792
def: "The process in which a virus effects a change in the structure or processes of its host organism." [GOC:bf, GOC:jl, ISBN:0781718325, UniProtKB-KW:KW-0945]
subset: goslim_virus
subset: virus_checked
synonym: "host-virus interaction" EXACT [GOC:bf, GOC:jl]
synonym: "modulation by virus of host anatomical structure or process" EXACT [GOC:bf, GOC:jl]
synonym: "modulation by virus of host anatomy or process" EXACT [GOC:bf, GOC:jl]
synonym: "viral interaction with host" EXACT []
synonym: "viral-host process" EXACT [GOC:bf, GOC:jl]
synonym: "virus-host interaction" BROAD [GOC:bf, GOC:jl]
synonym: "virus-host process" EXACT [GOC:bf, GOC:jl]
xref: Reactome:REACT_6323 "Host Interactions with Influenza Factors, Homo sapiens"
xref: VZ:886 "Vertebrate host-virus interactions"
is_a: GO:0016032 ! viral process
is_a: GO:0044003 ! modification by symbiont of host morphology or physiology

[Term]
id: GO:0019049
name: evasion or tolerance of host defenses by virus
namespace: biological_process
def: "Any process, either active or passive, by which a virus avoids or tolerates the effects of its host organism's defense(s). Host defenses may be induced by the presence of the virus or may be preformed (e.g. physical barriers). The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:1555811272]
synonym: "evasion of host defenses by virus" NARROW [GOC:bf, GOC:bm, GOC:jl]
synonym: "viral host defence evasion" NARROW []
synonym: "viral host defense evasion" NARROW []
is_a: GO:0019048 ! modulation by virus of host morphology or physiology
is_a: GO:0044415 ! evasion or tolerance of host defenses

[Term]
id: GO:0019050
name: suppression by virus of host apoptotic process
namespace: biological_process
def: "Any viral process that inhibits apoptosis of infected host cells, facilitating prolonged cell survival during viral replication." [GOC:mtg_apoptosis, ISBN:0781718325]
synonym: "negative regulation by virus of host apoptosis" EXACT []
synonym: "negative regulation of apoptosis by virus" EXACT []
synonym: "suppression by virus of host apoptosis" EXACT []
synonym: "suppression of apoptosis in host by virus" EXACT []
is_a: GO:0033668 ! negative regulation by symbiont of host apoptotic process
is_a: GO:0039526 ! modulation by virus of host apoptotic process

[Term]
id: GO:0019051
name: induction by virus of host apoptotic process
namespace: biological_process
def: "The set of viral processes that induce an apoptotic process in infected host cells, facilitating release and spread of progeny virions." [GOC:mtg_apoptosis, ISBN:0781718325]
synonym: "activation by virus of host apoptosis" EXACT []
synonym: "activation by virus of host apoptotic programmed cell death" EXACT []
synonym: "activation of apoptosis in host by virus" EXACT []
synonym: "induction by virus of host apoptosis" NARROW []
synonym: "induction by virus of host apoptotic programmed cell death" EXACT []
synonym: "induction of apoptosis in host by virus" EXACT []
is_a: GO:0039526 ! modulation by virus of host apoptotic process
is_a: GO:0060139 ! positive regulation of apoptotic process by virus

[Term]
id: GO:0019054
name: modulation by virus of host process
namespace: biological_process
def: "The process in which a virus effects a change in the processes and activities of its host organism." [GOC:jl]
subset: virus_checked
synonym: "modification by virus of host cellular process" EXACT []
synonym: "modulation of cellular process in host by virus" RELATED []
synonym: "regulation by virus of host cellular process" EXACT []
synonym: "regulation of cellular process in host by virus" EXACT []
synonym: "regulation of host cellular process by virus" EXACT []
synonym: "viral host cell process manipulation" EXACT []
xref: Reactome:REACT_6222 "NS1 Mediated Effects on Host Pathways, Homo sapiens"
is_a: GO:0019048 ! modulation by virus of host morphology or physiology
is_a: GO:0044068 ! modulation by symbiont of host cellular process

[Term]
id: GO:0019055
name: modification by virus of host cell cycle regulation
namespace: biological_process
def: "Interactions, directly with the host cell macromolecular machinery, to allow a virus to modulate the rate of the host cell cycle to facilitate virus replication." [GOC:dph, ISBN:0781718325]
synonym: "viral perturbation of cell cycle regulation" EXACT []
is_a: GO:0019054 ! modulation by virus of host process

[Term]
id: GO:0019056
name: modulation by virus of host transcription
namespace: biological_process
def: "Any process in which a virus modulates the frequency, rate or extent of its host's transcription." [ISBN:0781718325]
subset: goslim_virus
synonym: "modification by virus of host transcription" EXACT []
synonym: "viral perturbation of host cell transcription" EXACT []
is_a: GO:0006355 ! regulation of transcription, DNA-templated
is_a: GO:0039656 ! modulation by virus of host gene expression
is_a: GO:0052026 ! modulation by symbiont of host transcription

[Term]
id: GO:0019057
name: modulation by virus of host translation
namespace: biological_process
def: "Any process in which a virus modulates the frequency, rate or extent of translation of host mRNA." [ISBN:0781718325]
subset: goslim_virus
synonym: "host cell protein synthesis shutoff" BROAD []
synonym: "host cell shutoff" BROAD []
synonym: "modification by virus of host cell mRNA translation" EXACT []
synonym: "modulation of host translation by virus" EXACT [GOC:bf]
synonym: "regulation of host mRNA translation by virus" EXACT []
synonym: "regulation of host translation by virus" EXACT []
synonym: "regulation of translation in host by virus" EXACT []
synonym: "viral host shutoff protein" RELATED []
synonym: "viral perturbation of host cell mRNA translation" EXACT []
is_a: GO:0039656 ! modulation by virus of host gene expression
is_a: GO:0044073 ! modulation by symbiont of host translation

[Term]
id: GO:0019058
name: viral life cycle
namespace: biological_process
alt_id: GO:0019067
def: "A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome." [ISBN:1555811272]
synonym: "lytic viral life cycle" RELATED []
synonym: "viral assembly, maturation, egress, and release" NARROW [GOC:bf, GOC:jl]
synonym: "viral infectious cycle" RELATED [GOC:bf, GOC:jl]
synonym: "viral replication" RELATED [GOC:bf, GOC:jl]
xref: Reactome:REACT_6167 "Influenza Infection, Homo sapiens"
xref: Reactome:REACT_6270 "Virus Assembly and Release, Homo sapiens"
is_a: GO:0016032 ! viral process

[Term]
id: GO:0019059
name: obsolete initiation of viral infection
namespace: biological_process
def: "OBSOLETE. The set of processes involved in the start of virus infection of cells." [ISBN:0781702534]
comment: This term was made obsolete because it is ambiguous, and more specific terms have been created.
synonym: "initiation of viral infection" EXACT []
xref: Reactome:REACT_6266 "Early Phase of HIV Life Cycle, Homo sapiens"
is_obsolete: true
consider: GO:0046718

[Term]
id: GO:0019060
name: intracellular transport of viral protein in host cell
namespace: biological_process
alt_id: GO:0046742
alt_id: GO:0046743
alt_id: GO:0046801
def: "The directed movement of a viral protein within the host cell." [GOC:ai, ISBN:0781702534, ISBN:0781718325, PMID:11581394, PMID:9188566]
comment: This term is for annotation of the movement of individual viral proteins, rather than the whole viral particle.
subset: virus_checked
synonym: "cytoplasmic viral capsid transport" EXACT []
synonym: "intracellular transport of viral capsid in host cell" RELATED []
synonym: "intracellular transport of viral capsid protein in host cell" EXACT []
synonym: "intracellular transport of viral proteins in host cell" EXACT []
synonym: "intracellular viral capsid transport" EXACT []
synonym: "intracellular viral protein transport" EXACT []
synonym: "nuclear viral capsid transport" EXACT []
synonym: "viral capsid transport in host cell cytoplasm" EXACT []
synonym: "viral capsid transport in host cell nucleus" EXACT []
xref: Reactome:REACT_6215 "Transport of HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi Apparatus, Homo sapiens"
xref: Reactome:REACT_6225 "Budding of vesicle with the HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum into the cytosol, Homo sapiens"
xref: Reactome:REACT_6273 "Fusion of vesicle containing the HA trimer, NA tetramer and M2 tetramer to the Golgi apparatus, Homo sapiens"
xref: Reactome:REACT_6309 "Entry of HA into the endoplasmic reticulum, Homo sapiens"
is_a: GO:0030581 ! symbiont intracellular protein transport in host
is_a: GO:0075733 ! intracellular transport of virus
relationship: part_of GO:0046719 ! regulation by virus of viral protein levels in host cell

[Term]
id: GO:0019061
name: uncoating of virus
namespace: biological_process
def: "The process by which an incoming virus is disassembled in the host cell to release a replication-competent viral genome." [GOC:plm, ISBN:0781702534, PMID:8162442]
subset: virus_checked
synonym: "viral uncoating" EXACT [PMID:8162442]
xref: Reactome:REACT_6230 "Ribonucleoprotein release from M1 proteins, Homo sapiens"
xref: Reactome:REACT_6315 "Virion-associated M2 protein mediated ion infusion, Homo sapiens"
xref: Reactome:REACT_6321 "Uncoating of the Influenza Virion, Homo sapiens"
xref: Reactome:REACT_6965 "Uncoating of the HIV Virion, Homo sapiens"
is_a: GO:0016032 ! viral process

[Term]
id: GO:0019062
name: virion attachment to host cell
namespace: biological_process
def: "The process by which a virion protein binds to molecules on the host cellular surface or host cell surface projection." [GOC:bf, GOC:jl, UniProtKB-KW:KW-1161, VZ:956]
subset: goslim_virus
subset: virus_checked
synonym: "viral absorption" EXACT []
synonym: "viral attachment to host cell" RELATED [GOC:bf, GOC:jl]
synonym: "virion attachment to host cell surface receptor" NARROW []
xref: VZ:956 "Viral attachment to host cell"
is_a: GO:0044650 ! adhesion of symbiont to host cell
relationship: has_part GO:0046790 ! virion binding
relationship: has_part GO:0046812 ! host cell surface binding
relationship: part_of GO:0019058 ! viral life cycle

[Term]
id: GO:0019064
name: fusion of virus membrane with host plasma membrane
namespace: biological_process
alt_id: GO:0075706
def: "Fusion of a viral membrane with the host cell membrane during viral entry. Results in release of the virion contents into the cytoplasm." [GOC:bf, GOC:jl]
subset: virus_checked
synonym: "viral entry into host cell via membrane fusion with the plasma membrane" RELATED [GOC:bf, GOC:jl]
synonym: "viral envelope fusion" BROAD []
synonym: "viral envelope fusion with host cell membrane" EXACT []
synonym: "viral envelope fusion with host membrane" EXACT []
synonym: "viral envelope fusion with host plasma membrane" EXACT []
synonym: "viral penetration via membrane fusion" EXACT []
synonym: "viral-cell fusion molecule activity" RELATED []
xref: Reactome:REACT_6176 "Concerted hemagglutinin pore formation, Homo sapiens"
xref: Reactome:REACT_6180 "Fusion of the influenza virion HA2 protein transmembrane domain to the host cell endosome membrane, Homo sapiens"
xref: Reactome:REACT_6351 "Fusion of the Influenza Virion to the Host Cell Endosome, Homo sapiens"
xref: Reactome:REACT_8032 "Fusion of viral membrane with host cell membrane, Homo sapiens"
xref: VZ:987 "Fusion of virus membrane with host cell membrane"
is_a: GO:0039663 ! membrane fusion involved in viral entry into host cell

[Term]
id: GO:0019065
name: receptor-mediated endocytosis of virus by host cell
namespace: biological_process
def: "Any receptor-mediated endocytosis that is involved in the uptake of a virus into a host cell; successive instances of virus endocytosis result in the accumulation of virus particles within the cell." [GOC:bf, GOC:jl, ISBN:0781702534]
subset: virus_checked
synonym: "receptor mediated endocytosis by host of virus particle" EXACT []
synonym: "receptor mediated endocytosis of virus by host" EXACT []
synonym: "receptor mediated endocytosis of virus particle by host" EXACT []
synonym: "receptor-mediated endocytosis of virus by host" EXACT []
synonym: "viral entry into host cell via receptor-mediated endocytosis" RELATED [GOC:bf, GOC:jl]
synonym: "viral receptor mediated endocytosis" EXACT []
synonym: "virus receptor-mediated endocytosis by host" EXACT []
xref: Reactome:REACT_6147 "Entry of Influenza Virion into Host Cell via Endocytosis, Homo sapiens"
xref: Reactome:REACT_6262 "Clathrin-Mediated Pit Formation And Endocytosis Of The Influenza Virion, Homo sapiens"
is_a: GO:0006898 ! receptor-mediated endocytosis
is_a: GO:0075509 ! endocytosis involved in viral entry into host cell
intersection_of: GO:0006898 ! receptor-mediated endocytosis
intersection_of: part_of GO:0046718 ! viral entry into host cell
relationship: part_of GO:0046718 ! viral entry into host cell

[Term]
id: GO:0019066
name: obsolete translocation of virus into host cell
namespace: biological_process
def: "OBSOLETE. The translocation of an entire virus particle across the host cell plasma membrane." [ISBN:0781702534]
comment: This term was made obsolete because it is ambiguous, and more specific terms have been created.
synonym: "translocation of virus into host cell" EXACT []
synonym: "viral translocation" EXACT []
is_obsolete: true
replaced_by: GO:0046718

[Term]
id: GO:0019068
name: virion assembly
namespace: biological_process
alt_id: GO:0042963
def: "A late phase of the viral life cycle during which all the components necessary for the formation of a mature virion collect at a particular site in the cell and the basic structure of the virus particle is formed." [ISBN:0121585336]
subset: goslim_virus
subset: virus_checked
synonym: "bacteriophage assembly" NARROW [GOC:bm]
synonym: "phage assembly" NARROW [GOC:bm]
synonym: "viral assembly" EXACT []
synonym: "viral particle assembly" EXACT []
synonym: "virion assembly and maintenance" EXACT [GOC:bf, GOC:jl]
synonym: "virion organization" EXACT [GOC:bf, GOC:jl]
synonym: "virus assembly" EXACT [GOC:dph, GOC:tb]
synonym: "virus particle assembly" EXACT []
xref: Reactome:REACT_6137 "Accumulation of M1 at the inner leaflet of the lipid bilayer, Homo sapiens"
xref: Reactome:REACT_6146 "Association of HA into rafts, Homo sapiens"
xref: Reactome:REACT_6212 "Budding, Homo sapiens"
xref: Reactome:REACT_6271 "Association of NP into rafts, Homo sapiens"
xref: Reactome:REACT_6277 "Assembly of Viral Components at the Budding Site, Homo sapiens"
is_a: GO:0016032 ! viral process
is_a: GO:0022607 ! cellular component assembly
relationship: part_of GO:0019058 ! viral life cycle

[Term]
id: GO:0019069
name: viral capsid assembly
namespace: biological_process
def: "The assembly of a virus capsid from its protein subunits." [ISBN:0781702534, UniProtKB-KW:KW-0118]
subset: goslim_virus
is_a: GO:0016032 ! viral process
is_a: GO:0022607 ! cellular component assembly
relationship: part_of GO:0019068 ! virion assembly

[Term]
id: GO:0019070
name: viral genome maturation
namespace: biological_process
def: "The processes involved in creating a mature, stable viral genome. Begins after genome replication with a newly synthesized nucleic acid and ends when the genome is ready to be packaged. Includes the addition of proteins to the newly synthesized genome, and DNA repair processes." [GOC:pk, PMID:21490093]
xref: Reactome:REACT_6198 "Viral RNP Complexes in the Host Cell Nucleus, Homo sapiens"
is_a: GO:0016032 ! viral process
relationship: part_of GO:0019068 ! virion assembly

[Term]
id: GO:0019071
name: viral DNA cleavage involved in viral genome maturation
namespace: biological_process
def: "The cleavage of viral DNA into singular functional units." [ISBN:0121585336]
is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis
relationship: part_of GO:0019070 ! viral genome maturation

[Term]
id: GO:0019072
name: viral genome packaging
namespace: biological_process
def: "The encapsulation of the viral genome within the capsid." [ISBN:0121585336]
subset: goslim_virus
subset: virus_checked
xref: Reactome:REACT_6235 "Packaging of Eight RNA Segments, Homo sapiens"
xref: Reactome:REACT_6336 "RNP association, Homo sapiens"
is_a: GO:0016032 ! viral process
relationship: part_of GO:0019068 ! virion assembly

[Term]
id: GO:0019073
name: viral DNA genome packaging
namespace: biological_process
def: "The packing of viral DNA into a capsid." [ISBN:0781702534]
subset: virus_checked
is_a: GO:0006259 ! DNA metabolic process
is_a: GO:0006323 ! DNA packaging
is_a: GO:0019072 ! viral genome packaging
is_a: GO:0044033 ! multi-organism metabolic process
is_a: GO:1902590 ! multi-organism organelle organization

[Term]
id: GO:0019074
name: viral RNA genome packaging
namespace: biological_process
def: "The packaging of viral RNA (single-stranded or double-stranded) into a nucleocapsid." [ISBN:0781718325]
is_a: GO:0019072 ! viral genome packaging

[Term]
id: GO:0019075
name: virus maturation
namespace: biological_process
def: "The refolding and structural rearrangements of virion parts to transition from the intermediate virion to the more mature virion. Maturation usually involves proteolysis events and changes in the folding of the virion proteins. Can occur inside the host cell or after release." [ISBN:0781718325, UniProtKB-KW:KW-0917, VZ:1946]
synonym: "bacteriophage maturation" NARROW [PMID:22308333]
synonym: "viral maturation" EXACT []
synonym: "viral particle maturation" EXACT []
synonym: "virion maturation" EXACT [UniProtKB-KW:KW-0917]
synonym: "virus particle maturation" RELATED []
xref: VZ:1946
is_a: GO:0016032 ! viral process
relationship: part_of GO:0019058 ! viral life cycle

[Term]
id: GO:0019076
name: viral release from host cell
namespace: biological_process
def: "The dissemination of mature viral particles from the host cell, e.g. by cell lysis or the budding of virus particles from the cell membrane." [GOC:jl]
subset: goslim_virus
subset: virus_checked
synonym: "release of virus from host" EXACT []
synonym: "viral exit" EXACT []
synonym: "viral release" EXACT []
synonym: "viral shedding" EXACT []
synonym: "virus exit from host cell" EXACT [GOC:bf, GOC:jl]
xref: Reactome:REACT_6326 "Release, Homo sapiens"
xref: Reactome:REACT_6348 "Neuraminidase enzymatic release from sialic acid, Homo sapiens"
xref: VZ:1076 "Virus exit from host cell"
is_a: GO:0016032 ! viral process
relationship: part_of GO:0019058 ! viral life cycle

[Term]
id: GO:0019078
name: obsolete lytic viral budding
namespace: biological_process
def: "OBSOLETE. A form of viral release in which the viral particles bud out through cellular membranes, resulting in cell lysis. It is also a form of viral envelopment." [ISBN:0781702534]
comment: This term was made obsolete because it does not appear to correspond to a real biological process.
synonym: "lytic viral budding" EXACT []
is_obsolete: true

[Term]
id: GO:0019079
name: viral genome replication
namespace: biological_process
def: "Any process involved directly in viral genome replication, including viral nucleotide metabolism." [ISBN:0781702534]
subset: goslim_virus
synonym: "sigma virus replication" NARROW []
synonym: "viral replication" BROAD []
is_a: GO:0016032 ! viral process
relationship: part_of GO:0019058 ! viral life cycle

[Term]
id: GO:0019080
name: viral gene expression
namespace: biological_process
def: "A process by which a viral gene is converted into a mature gene product or products (proteins or RNA). This includes viral transcription, processing to produce a mature RNA product, and viral translation." [GOC:bf, GOC:jl, ISBN:0121585336]
subset: virus_checked
synonym: "viral genome expression" EXACT [GOC:jl]
is_a: GO:0010467 ! gene expression
is_a: GO:0016032 ! viral process
is_a: GO:0044033 ! multi-organism metabolic process
intersection_of: GO:0010467 ! gene expression
intersection_of: part_of GO:0019058 ! viral life cycle
relationship: part_of GO:0019058 ! viral life cycle

[Term]
id: GO:0019081
name: viral translation
namespace: biological_process
def: "A process by which viral mRNA is translated into viral protein, using the host cellular machinery." [GOC:bf, GOC:jl, ISBN:0781702534]
subset: goslim_virus
subset: virus_checked
synonym: "viral protein anabolism" EXACT []
synonym: "viral protein biosynthesis" EXACT []
synonym: "viral protein biosynthetic process" EXACT [ISBN:0781702534]
synonym: "viral protein formation" EXACT []
synonym: "viral protein synthesis" EXACT []
is_a: GO:0006412 ! translation
intersection_of: GO:0006412 ! translation
intersection_of: part_of GO:0019080 ! viral gene expression
relationship: part_of GO:0019080 ! viral gene expression

[Term]
id: GO:0019082
name: viral protein processing
namespace: biological_process
def: "Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a viral protein." [GOC:bf, GOC:jl, ISBN:0781702534]
subset: virus_checked
xref: Reactome:REACT_6141 "Trimerization of HA, Homo sapiens"
xref: Reactome:REACT_6187 "Palmitoylation of cysteine residues on HA in the cis-Golgi network, Homo sapiens"
is_a: GO:0016485 ! protein processing
intersection_of: GO:0016485 ! protein processing
intersection_of: part_of GO:0019080 ! viral gene expression
relationship: part_of GO:0019080 ! viral gene expression

[Term]
id: GO:0019083
name: viral transcription
namespace: biological_process
def: "The process by which a viral genome, or part of a viral genome, is transcribed within the host cell." [GOC:jl, ISBN:0781702534]
subset: goslim_virus
xref: Reactome:REACT_6142 "Assembly of an Active Transcription Complex, Homo sapiens"
xref: Reactome:REACT_6152 "Influenza Viral RNA Transcription and Replication, Homo sapiens"
xref: Reactome:REACT_6210 "Elongation of viral mRNA, Homo sapiens"
xref: Reactome:REACT_6233 "Transcription of the HIV genome, Homo sapiens"
xref: Reactome:REACT_6239 "Priming and Initiation of Transcription, Homo sapiens"
xref: Reactome:REACT_6264 "Polyadenylation and Termination, Homo sapiens"
xref: Reactome:REACT_6354 "Viral Messenger RNA Synthesis, Homo sapiens"
is_a: GO:0032774 ! RNA biosynthetic process
intersection_of: GO:0032774 ! RNA biosynthetic process
intersection_of: part_of GO:0019080 ! viral gene expression
relationship: part_of GO:0019080 ! viral gene expression

[Term]
id: GO:0019084
name: middle viral transcription
namespace: biological_process
def: "The viral transcription that takes place after early transcription in the viral life cycle, and which involves the transcription of genes required for replication." [GOC:bf, GOC:jl]
synonym: "(delayed) early viral mRNA transcription" RELATED [GOC:jh2]
is_a: GO:0019083 ! viral transcription

[Term]
id: GO:0019085
name: early viral transcription
namespace: biological_process
def: "The first phase of viral transcription that occurs after entry of the virus into the host cell, but prior to viral genome replication. It involves the transcription of genes for non-structural proteins, and for lytic viruses, the early gene products are involved in establishing control over the host cell." [GOC:bf, GOC:jh2, GOC:jl]
synonym: "immediate early viral mRNA transcription" RELATED []
is_a: GO:0019083 ! viral transcription

[Term]
id: GO:0019086
name: late viral transcription
namespace: biological_process
def: "The transcription of the final group of viral genes of the viral life cycle, following middle transcription, or where middle transcription doesn't occur, following early transcription. Involves the transcription of genes encoding structural proteins." [GOC:bf, GOC:jh2, GOC:jl]
synonym: "late viral mRNA transcription" RELATED []
is_a: GO:0019083 ! viral transcription

[Term]
id: GO:0019087
name: transformation of host cell by virus
namespace: biological_process
def: "Any virus-induced change in the morphological, biochemical, or growth parameters of a cell." [ISBN:0781702534]
synonym: "viral transformation" EXACT []
synonym: "viral transformation of host cell" EXACT []
xref: Wikipedia:Viral_transformation
is_a: GO:0019048 ! modulation by virus of host morphology or physiology

[Term]
id: GO:0019088
name: immortalization of host cell by virus
namespace: biological_process
def: "A virus-induced cellular transformation arising in immortalized cells, or cells capable of indefinite replication, due to their ability to produce their own telomerase." [ISBN:0781702534, PMID:24373315]
synonym: "viral immortalization" EXACT []
is_a: GO:0019087 ! transformation of host cell by virus
is_a: GO:0020021 ! immortalization of host cell

[Term]
id: GO:0019089
name: transmission of virus
namespace: biological_process
def: "The transfer of virions in order to create new infection." [ISBN:0781702534]
synonym: "viral transmission" EXACT []
is_a: GO:0016032 ! viral process
is_a: GO:0044007 ! dissemination or transmission of symbiont from host

[Term]
id: GO:0019090
name: mitochondrial rRNA export from mitochondrion
namespace: biological_process
def: "The directed movement of mitochondrial rRNA out of a mitochondrion." [GOC:ai]
synonym: "export of mitochondrial rRNA" BROAD []
synonym: "mitochondrial rRNA export" EXACT []
synonym: "mitochondrial rRNA export from mitochondria" EXACT []
synonym: "mitochondrial rRNA export out of mitochondrion" EXACT []
synonym: "mitochondrial rRNA transport from mitochondrion" EXACT []
synonym: "mitochondrial rRNA, mitochondrial export" EXACT []
is_a: GO:0006839 ! mitochondrial transport
is_a: GO:0051029 ! rRNA transport
relationship: occurs_in GO:0005737 ! cytoplasm
relationship: part_of GO:0019093 ! mitochondrial RNA localization

[Term]
id: GO:0019091
name: mitochondrial lrRNA export from mitochondrion
namespace: biological_process
def: "The directed movement of mitochondrial lrRNA out of a mitochondrion." [GOC:ai]
synonym: "export of mitochondrial lrRNA" BROAD []
synonym: "mitochondrial lrRNA export" EXACT []
synonym: "mitochondrial lrRNA export from mitochondria" EXACT []
synonym: "mitochondrial lrRNA export out of mitochondrion" EXACT []
synonym: "mitochondrial lrRNA transport from mitochondrion" EXACT []
synonym: "mitochondrial lrRNA, mitochondrial export" EXACT []
is_a: GO:0019090 ! mitochondrial rRNA export from mitochondrion

[Term]
id: GO:0019092
name: mitochondrial srRNA export from mitochondrion
namespace: biological_process
def: "The directed movement of mitochondrial srRNA out of a mitochondrion." [GOC:ai]
synonym: "export of mitochondrial srRNA" BROAD []
synonym: "mitochondrial srRNA export" EXACT []
synonym: "mitochondrial srRNA export from mitochondria" EXACT []
synonym: "mitochondrial srRNA export out of mitochondrion" EXACT []
synonym: "mitochondrial srRNA transport from mitochondrion" EXACT []
synonym: "mitochondrial srRNA, mitochondrial export" EXACT []
is_a: GO:0019090 ! mitochondrial rRNA export from mitochondrion

[Term]
id: GO:0019093
name: mitochondrial RNA localization
namespace: biological_process
def: "Any process in which mitochondrial RNA is transported to, or maintained in, a specific location." [GOC:ai]
synonym: "establishment and maintenance of mitochondrial RNA localization" EXACT []
synonym: "mitochondrial RNA localisation" EXACT [GOC:mah]
synonym: "mtRNA localization" EXACT []
is_a: GO:0006403 ! RNA localization
intersection_of: GO:0006403 ! RNA localization
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion

[Term]
id: GO:0019094
name: pole plasm mRNA localization
namespace: biological_process
alt_id: GO:0048120
def: "Any process in which mRNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [GOC:ai]
synonym: "establishment and maintenance of mRNA localization in pole plasm" EXACT []
synonym: "establishment and maintenance of pole plasm mRNA localization" EXACT []
synonym: "oocyte pole plasm mRNA localization" EXACT []
synonym: "pole granule RNA localization" BROAD []
synonym: "pole plasm mRNA localisation" EXACT [GOC:mah]
is_a: GO:0007316 ! pole plasm RNA localization
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0060811 ! intracellular mRNA localization involved in anterior/posterior axis specification
is_a: GO:1902580 ! single-organism cellular localization

[Term]
id: GO:0019095
name: pole plasm mitochondrial rRNA localization
namespace: biological_process
alt_id: GO:0048117
def: "Any process in which mitochondrial ribosomal RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [ISBN:0879694238]
synonym: "establishment and maintenance of mitochondrial rRNA localization in pole plasm" EXACT []
synonym: "oocyte pole plasm mitochondrial rRNA localization" EXACT []
synonym: "pole plasm mitochondrial rRNA localisation" EXACT [GOC:mah]
is_a: GO:0007316 ! pole plasm RNA localization
is_a: GO:0019093 ! mitochondrial RNA localization

[Term]
id: GO:0019096
name: pole plasm mitochondrial lrRNA localization
namespace: biological_process
alt_id: GO:0048118
def: "Any process in which mitochondrial large ribosomal RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [ISBN:0879694238]
synonym: "establishment and maintenance of mitochondrial lrRNA localization in pole plasm" EXACT []
synonym: "oocyte pole plasm mitochondrial lrRNA localization" EXACT []
synonym: "pole plasm mitochondrial lrRNA localisation" EXACT [GOC:mah]
is_a: GO:0019095 ! pole plasm mitochondrial rRNA localization

[Term]
id: GO:0019097
name: pole plasm mitochondrial srRNA localization
namespace: biological_process
alt_id: GO:0048119
def: "Any process in which mitochondrial small ribosomal RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [ISBN:0879694238]
synonym: "establishment and maintenance of mitochondrial localization in pole plasm" EXACT []
synonym: "oocyte pole plasm mitochondrial srRNA localization" EXACT []
synonym: "pole plasm mitochondrial srRNA localisation" EXACT [GOC:mah]
is_a: GO:0019095 ! pole plasm mitochondrial rRNA localization

[Term]
id: GO:0019098
name: reproductive behavior
namespace: biological_process
alt_id: GO:0033057
def: "The specific behavior of an organism that is associated with reproduction." [GOC:jl, GOC:pr]
synonym: "multicellular organism reproductive behavior" NARROW []
synonym: "reproductive behavior in a multicellular organism" EXACT [GOC:curators]
synonym: "reproductive behaviour" EXACT []
is_a: GO:0007610 ! behavior
is_a: GO:0048609 ! multicellular organismal reproductive process
intersection_of: GO:0007610 ! behavior
intersection_of: part_of GO:0000003 ! reproduction
relationship: part_of GO:0000003 ! reproduction

[Term]
id: GO:0019099
name: female germ-line sex determination
namespace: biological_process
alt_id: GO:0007544
def: "The determination of sex and sexual phenotype in a female organism's germ line." [GOC:mah]
synonym: "sex determination, female germ-line determination" EXACT []
is_a: GO:0007542 ! primary sex determination, germ-line
is_a: GO:0018992 ! germ-line sex determination
is_a: GO:0030237 ! female sex determination

[Term]
id: GO:0019100
name: male germ-line sex determination
namespace: biological_process
def: "The determination of sex and sexual phenotype in a male organism's germ line." [GOC:mah]
is_a: GO:0007542 ! primary sex determination, germ-line
is_a: GO:0018992 ! germ-line sex determination
is_a: GO:0030238 ! male sex determination

[Term]
id: GO:0019101
name: female somatic sex determination
namespace: biological_process
def: "The determination of sex and sexual phenotypes in a female organism's soma." [GOC:mah]
is_a: GO:0018993 ! somatic sex determination
is_a: GO:0030237 ! female sex determination

[Term]
id: GO:0019102
name: male somatic sex determination
namespace: biological_process
def: "The determination of sex and sexual phenotypes in a male organism's soma." [GOC:mah]
is_a: GO:0018993 ! somatic sex determination
is_a: GO:0030238 ! male sex determination

[Term]
id: GO:0019103
name: pyrimidine nucleotide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate." [GOC:ai]
is_a: GO:0000166 ! nucleotide binding

[Term]
id: GO:0019104
name: DNA N-glycosylase activity
namespace: molecular_function
alt_id: GO:0008578
def: "Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site." [GOC:elh, PMID:11554296]
subset: gosubset_prok
synonym: "DNA glycosylase activity" EXACT []
synonym: "endonuclease VIII activity" RELATED []
xref: EC:3.2.2.-
xref: Reactome:REACT_100184 "Cleavage of ethenoadenine by MPG glycosylase, Sus scrofa"
xref: Reactome:REACT_100211 "Cleavage of thymine by MBD4 glycosylase, Oryza sativa"
xref: Reactome:REACT_100545 "Cleavage of 3-methyladenine by MPG glycosylase, Staphylococcus aureus N315"
xref: Reactome:REACT_100572 "Cleavage of 3-methyladenine by MPG glycosylase, Bos taurus"
xref: Reactome:REACT_100860 "Cleavage of thymine by TDG glycosylase, Danio rerio"
xref: Reactome:REACT_101772 "Cleavage of thymine by TDG glycosylase, Xenopus tropicalis"
xref: Reactome:REACT_101927 "Cleavage of uracil by MBD4 glycosylase, Xenopus tropicalis"
xref: Reactome:REACT_102102 "Cleavage of ethenoadenine by MPG glycosylase, Bos taurus"
xref: Reactome:REACT_102526 "TDG glycosylase mediated recognition and binding of an thymine opposite to a guanine, Escherichia coli"
xref: Reactome:REACT_102669 "Cleavage of ethenocytosine by TDG glycosylase, Bos taurus"
xref: Reactome:REACT_102750 "Cleavage of ethenoadenine by MPG glycosylase, Rattus norvegicus"
xref: Reactome:REACT_103152 "Cleavage of hypoxanthine by MPG glycosylase, Mus musculus"
xref: Reactome:REACT_103163 "Cleavage of ethenoadenine by MPG glycosylase, Xenopus tropicalis"
xref: Reactome:REACT_103679 "Cleavage of ethenoadenine by MPG glycosylase, Mus musculus"
xref: Reactome:REACT_104296 "Cleavage of thymine by MBD4 glycosylase, Bos taurus"
xref: Reactome:REACT_104393 "Cleavage of thymine by TDG glycosylase, Schizosaccharomyces pombe"
xref: Reactome:REACT_104604 "Cleavage of ethenocytosine by TDG glycosylase, Schizosaccharomyces pombe"
xref: Reactome:REACT_104916 "Cleavage of thymine by MBD4 glycosylase, Taeniopygia guttata"
xref: Reactome:REACT_105162 "Cleavage of ethenocytosine by TDG glycosylase, Danio rerio"
xref: Reactome:REACT_105255 "Cleavage 8-oxo guanine by MYH glycosylase, Taeniopygia guttata"
xref: Reactome:REACT_105536 "Cleavage of ethenocytosine by TDG glycosylase, Canis familiaris"
xref: Reactome:REACT_106436 "Cleavage of 3-methyladenine by MPG glycosylase, Mycobacterium tuberculosis"
xref: Reactome:REACT_106517 "Cleavage of 3-methyladenine by MPG glycosylase, Taeniopygia guttata"
xref: Reactome:REACT_106727 "Cleavage of thymine by MBD4 glycosylase, Canis familiaris"
xref: Reactome:REACT_107229 "Cleavage of uracil by MBD4 glycosylase, Taeniopygia guttata"
xref: Reactome:REACT_107507 "Cleavage of thymine by MBD4 glycosylase, Rattus norvegicus"
xref: Reactome:REACT_107862 "Cleavage of uracil by MBD4 glycosylase, Sus scrofa"
xref: Reactome:REACT_108034 "Cleavage of 3-methyladenine by MPG glycosylase, Danio rerio"
xref: Reactome:REACT_108184 "Cleavage of 3-methyladenine by MPG glycosylase, Plasmodium falciparum"
xref: Reactome:REACT_108420 "Cleavage of 3-methyladenine by MPG glycosylase, Oryza sativa"
xref: Reactome:REACT_108859 "Cleavage 8-oxo guanine by MYH glycosylase, Plasmodium falciparum"
xref: Reactome:REACT_109496 "Cleavage 8-oxo guanine by MYH glycosylase, Arabidopsis thaliana"
xref: Reactome:REACT_109568 "Cleavage 8-oxo guanine by MYH glycosylase, Schizosaccharomyces pombe"
xref: Reactome:REACT_109794 "Cleavage 8-oxo guanine by MYH glycosylase, Canis familiaris"
xref: Reactome:REACT_110244 "TDG glycosylase mediated recognition and binding of an thymine opposite to a guanine, Schizosaccharomyces pombe"
xref: Reactome:REACT_110279 "Cleavage of uracil by MBD4 glycosylase, Oryza sativa"
xref: Reactome:REACT_115660 "TDG glycosylase mediated recognition and binding of thymine opposite guanine, Gallus gallus"
xref: Reactome:REACT_115848 "5-methylcytosine G/T mismatch specific DNA glycosylase mediated recognition and binding of thymine opposite guanine at CpG sequences, Gallus gallus"
xref: Reactome:REACT_116111 "Cleavage of thymine by 5-methylcytosine G/T mismatch specific glycosylase, Gallus gallus"
xref: Reactome:REACT_116119 "Cleavage of thymine by TDG glycosylase, Gallus gallus"
xref: Reactome:REACT_1229 "Cleavage of ethenocytosine by TDG glycosylase, Homo sapiens"
xref: Reactome:REACT_1600 "TDG glycosylase mediated recognition and binding of an thymine opposite to a guanine, Homo sapiens"
xref: Reactome:REACT_28101 "Cleavage of hypoxanthine by MPG glycosylase, Gallus gallus"
xref: Reactome:REACT_28159 "Cleavage of thymine by TDG glycosylase, Canis familiaris"
xref: Reactome:REACT_28176 "Cleavage of ethenoadenine by MPG glycosylase, Danio rerio"
xref: Reactome:REACT_28208 "TDG glycosylase mediated recognition and binding of an thymine opposite to a guanine, Drosophila melanogaster"
xref: Reactome:REACT_28786 "Cleavage 8-oxo guanine by MYH glycosylase, Oryza sativa"
xref: Reactome:REACT_29247 "Cleavage of thymine by TDG glycosylase, Rattus norvegicus"
xref: Reactome:REACT_29392 "Cleavage of ethenocytosine by TDG glycosylase, Drosophila melanogaster"
xref: Reactome:REACT_29546 "Cleavage of thymine by TDG glycosylase, Mus musculus"
xref: Reactome:REACT_29690 "Cleavage of ethenocytosine by TDG glycosylase, Mus musculus"
xref: Reactome:REACT_29777 "Cleavage of ethenocytosine by TDG glycosylase, Gallus gallus"
xref: Reactome:REACT_30040 "Cleavage of hypoxanthine by MPG glycosylase, Bos taurus"
xref: Reactome:REACT_303 "Cleavage of uracil by MBD4 glycosylase, Homo sapiens"
xref: Reactome:REACT_30768 "Cleavage of thymine by MBD4 glycosylase, Sus scrofa"
xref: Reactome:REACT_31100 "Cleavage 8-oxo guanine by MYH glycosylase, Xenopus tropicalis"
xref: Reactome:REACT_32470 "Cleavage of ethenocytosine by TDG glycosylase, Escherichia coli"
xref: Reactome:REACT_33120 "Cleavage of thymine by MBD4 glycosylase, Xenopus tropicalis"
xref: Reactome:REACT_33202 "TDG glycosylase mediated recognition and binding of an thymine opposite to a guanine, Rattus norvegicus"
xref: Reactome:REACT_33763 "Cleavage of uracil by MBD4 glycosylase, Gallus gallus"
xref: Reactome:REACT_34055 "Cleavage of ethenocytosine by TDG glycosylase, Rattus norvegicus"
xref: Reactome:REACT_34400 "Cleavage 8-oxo guanine by MYH glycosylase, Escherichia coli"
xref: Reactome:REACT_34443 "Cleavage of thymine by MBD4 glycosylase, Gallus gallus"
xref: Reactome:REACT_34733 "Cleavage of hypoxanthine by MPG glycosylase, Rattus norvegicus"
xref: Reactome:REACT_492 "Cleavage of hypoxanthine by MPG glycosylase, Homo sapiens"
xref: Reactome:REACT_77896 "Cleavage of uracil by MBD4 glycosylase, Arabidopsis thaliana"
xref: Reactome:REACT_77932 "Cleavage of hypoxanthine by MPG glycosylase, Oryza sativa"
xref: Reactome:REACT_78986 "Cleavage of thymine by MBD4 glycosylase, Arabidopsis thaliana"
xref: Reactome:REACT_79292 "Cleavage 8-oxo guanine by MYH glycosylase, Sus scrofa"
xref: Reactome:REACT_80125 "Cleavage of thymine by TDG glycosylase, Bos taurus"
xref: Reactome:REACT_80550 "Cleavage of 3-methyladenine by MPG glycosylase, Mus musculus"
xref: Reactome:REACT_80623 "TDG glycosylase mediated recognition and binding of an thymine opposite to a guanine, Taeniopygia guttata"
xref: Reactome:REACT_81484 "Cleavage of uracil by MBD4 glycosylase, Mus musculus"
xref: Reactome:REACT_81566 "Cleavage of 3-methyladenine by MPG glycosylase, Rattus norvegicus"
xref: Reactome:REACT_81785 "Cleavage 8-oxo guanine by MYH glycosylase, Bos taurus"
xref: Reactome:REACT_818 "Cleavage 8-oxo guanine by MYH glycosylase, Homo sapiens"
xref: Reactome:REACT_81966 "Cleavage 8-oxo guanine by MYH glycosylase, Gallus gallus"
xref: Reactome:REACT_82826 "Cleavage of 3-methyladenine by MPG glycosylase, Sus scrofa"
xref: Reactome:REACT_82842 "Cleavage of hypoxanthine by MPG glycosylase, Arabidopsis thaliana"
xref: Reactome:REACT_82858 "Cleavage of ethenoadenine by MPG glycosylase, Plasmodium falciparum"
xref: Reactome:REACT_82984 "TDG glycosylase mediated recognition and binding of an thymine opposite to a guanine, Danio rerio"
xref: Reactome:REACT_83090 "Cleavage of ethenoadenine by MPG glycosylase, Mycobacterium tuberculosis"
xref: Reactome:REACT_83448 "Cleavage of ethenoadenine by MPG glycosylase, Oryza sativa"
xref: Reactome:REACT_840 "Cleavage of thymine by MBD4 glycosylase, Homo sapiens"
xref: Reactome:REACT_84320 "TDG glycosylase mediated recognition and binding of an thymine opposite to a guanine, Canis familiaris"
xref: Reactome:REACT_84884 "Cleavage 8-oxo guanine by MYH glycosylase, Mus musculus"
xref: Reactome:REACT_85353 "Cleavage of hypoxanthine by MPG glycosylase, Danio rerio"
xref: Reactome:REACT_86036 "Cleavage of hypoxanthine by MPG glycosylase, Canis familiaris"
xref: Reactome:REACT_86302 "Cleavage of hypoxanthine by MPG glycosylase, Mycobacterium tuberculosis"
xref: Reactome:REACT_86538 "Cleavage of 3-methyladenine by MPG glycosylase, Canis familiaris"
xref: Reactome:REACT_86544 "TDG glycosylase mediated recognition and binding of an thymine opposite to a guanine, Mus musculus"
xref: Reactome:REACT_86715 "Cleavage of 3-methyladenine by MPG glycosylase, Gallus gallus"
xref: Reactome:REACT_87262 "Cleavage of uracil by MBD4 glycosylase, Bos taurus"
xref: Reactome:REACT_87430 "Cleavage of ethenoadenine by MPG glycosylase, Canis familiaris"
xref: Reactome:REACT_88132 "Cleavage of hypoxanthine by MPG glycosylase, Taeniopygia guttata"
xref: Reactome:REACT_88592 "TDG glycosylase mediated recognition and binding of an thymine opposite to a guanine, Bos taurus"
xref: Reactome:REACT_89084 "Cleavage of ethenocytosine by TDG glycosylase, Taeniopygia guttata"
xref: Reactome:REACT_89263 "Cleavage of thymine by MBD4 glycosylase, Mus musculus"
xref: Reactome:REACT_89512 "Cleavage of ethenoadenine by MPG glycosylase, Staphylococcus aureus N315"
xref: Reactome:REACT_90213 "Cleavage of ethenoadenine by MPG glycosylase, Arabidopsis thaliana"
xref: Reactome:REACT_90264 "Cleavage of thymine by TDG glycosylase, Taeniopygia guttata"
xref: Reactome:REACT_90642 "Cleavage of ethenocytosine by TDG glycosylase, Xenopus tropicalis"
xref: Reactome:REACT_90755 "Cleavage of uracil by MBD4 glycosylase, Rattus norvegicus"
xref: Reactome:REACT_909 "Cleavage of ethenoadenine by MPG glycosylase, Homo sapiens"
xref: Reactome:REACT_91077 "Cleavage 8-oxo guanine by MYH glycosylase, Mycobacterium tuberculosis"
xref: Reactome:REACT_91215 "TDG glycosylase mediated recognition and binding of an thymine opposite to a guanine, Xenopus tropicalis"
xref: Reactome:REACT_91219 "Cleavage of uracil by MBD4 glycosylase, Canis familiaris"
xref: Reactome:REACT_91653 "Cleavage of ethenoadenine by MPG glycosylase, Gallus gallus"
xref: Reactome:REACT_92 "Cleavage of thymine by TDG glycosylase, Homo sapiens"
xref: Reactome:REACT_924 "Cleavage of 3-methyladenine by MPG glycosylase, Homo sapiens"
xref: Reactome:REACT_92760 "Cleavage of ethenoadenine by MPG glycosylase, Taeniopygia guttata"
xref: Reactome:REACT_93435 "Cleavage of thymine by TDG glycosylase, Sus scrofa"
xref: Reactome:REACT_94574 "Cleavage 8-oxo guanine by MYH glycosylase, Staphylococcus aureus N315"
xref: Reactome:REACT_94831 "Cleavage of thymine by TDG glycosylase, Escherichia coli"
xref: Reactome:REACT_94922 "Cleavage 8-oxo guanine by MYH glycosylase, Rattus norvegicus"
xref: Reactome:REACT_95394 "Cleavage of ethenocytosine by TDG glycosylase, Sus scrofa"
xref: Reactome:REACT_95577 "Cleavage of thymine by TDG glycosylase, Drosophila melanogaster"
xref: Reactome:REACT_96015 "Cleavage 8-oxo guanine by MYH glycosylase, Dictyostelium discoideum"
xref: Reactome:REACT_96296 "Cleavage of hypoxanthine by MPG glycosylase, Xenopus tropicalis"
xref: Reactome:REACT_96301 "Cleavage of hypoxanthine by MPG glycosylase, Staphylococcus aureus N315"
xref: Reactome:REACT_96358 "Cleavage of hypoxanthine by MPG glycosylase, Plasmodium falciparum"
xref: Reactome:REACT_96363 "Cleavage of 3-methyladenine by MPG glycosylase, Xenopus tropicalis"
xref: Reactome:REACT_96410 "Cleavage of hypoxanthine by MPG glycosylase, Sus scrofa"
xref: Reactome:REACT_98134 "Cleavage of thymine by TDG glycosylase, Gallus gallus"
xref: Reactome:REACT_98153 "TDG glycosylase mediated recognition and binding of an thymine opposite to a guanine, Sus scrofa"
xref: Reactome:REACT_98446 "Cleavage 8-oxo guanine by MYH glycosylase, Danio rerio"
xref: Reactome:REACT_98817 "TDG glycosylase mediated recognition and binding of an thymine opposite to a guanine, Gallus gallus"
xref: Reactome:REACT_99235 "Cleavage of 3-methyladenine by MPG glycosylase, Arabidopsis thaliana"
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0019105
name: N-palmitoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a palmitoyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]
xref: EC:2.3.1.-
is_a: GO:0016409 ! palmitoyltransferase activity
is_a: GO:0016410 ! N-acyltransferase activity

[Term]
id: GO:0019107
name: myristoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a myristoyl (CH3-[CH2]12-CO-) group to an acceptor molecule." [GOC:ai]
xref: EC:2.3.1.-
xref: Reactome:REACT_1158 "Myristoylation of tBID by NMT1, Homo sapiens"
xref: Reactome:REACT_116143 "Myristoylation of Nef, Homo sapiens"
xref: Reactome:REACT_29644 "Myristoylation of tBID by NMT1, Taeniopygia guttata"
xref: Reactome:REACT_32161 "Myristoylation of tBID by NMT1, Bos taurus"
xref: Reactome:REACT_34257 "Myristoylation of tBID by NMT1, Sus scrofa"
xref: Reactome:REACT_82136 "Myristoylation of tBID by NMT1, Gallus gallus"
xref: Reactome:REACT_84792 "Myristoylation of tBID by NMT1, Xenopus tropicalis"
xref: Reactome:REACT_88838 "Myristoylation of tBID by NMT1, Mus musculus"
xref: Reactome:REACT_93850 "Myristoylation of tBID by NMT1, Canis familiaris"
xref: Reactome:REACT_97643 "Myristoylation of tBID by NMT1, Rattus norvegicus"
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0019108
name: aryl-aldehyde dehydrogenase (NAD) activity
namespace: molecular_function
def: "Catalysis of the reaction: an aromatic aldehyde + NAD+ + H2O = an aromatic acid + NADH + H+." [EC:1.2.1.29]
synonym: "aryl-aldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.29]
xref: EC:1.2.1.29
xref: MetaCyc:ARYL-ALDEHYDE-DEHYDROGENASE-RXN
xref: UM-BBD_reactionID:r0394
is_a: GO:0004029 ! aldehyde dehydrogenase (NAD) activity

[Term]
id: GO:0019111
name: phenanthrol sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenanthrol + X-SO3(-) = HX + phenanthrylsulfate." [EC:2.8.2.-]
synonym: "phenanthrol sulphotransferase activity" EXACT []
xref: EC:2.8.2.-
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0019112
name: phenanthrol glycosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenanthrol + glucose = phenanthryl-beta-D-glucopyranoside + H2O." [GOC:ai]
xref: EC:2.4.1.-
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0019113
name: limonene monooxygenase activity
namespace: molecular_function
def: "Catalysis of a monooxygenase reaction in which oxygen is incorporated into limonene." [GOC:mah]
xref: EC:1.14.13.-
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0019114
name: catechol dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: catechol + O2 = a muconate." [GOC:mah, MetaCyc:CATECHOL-12-DIOXYGENASE-RXN, MetaCyc:CATECHOL-23-DIOXYGENASE-RXN]
subset: gosubset_prok
xref: EC:1.13.11.-
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0019115
name: benzaldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzaldehyde + NAD(P)+ + H2O = benzoate + NAD(P)H + H+." [EC:1.2.1.28, EC:1.2.1.7]
subset: gosubset_prok
xref: EC:1.2.1.-
is_a: GO:0004030 ! aldehyde dehydrogenase [NAD(P)+] activity

[Term]
id: GO:0019116
name: hydroxy-nicotine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-hydroxynicotine + H2O + O2 = 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + hydrogen peroxide." [GOC:jl, http://umbbd.ahc.umn.edu/]
subset: gosubset_prok
xref: EC:1.5.3.-
is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor

[Term]
id: GO:0019117
name: dihydroxyfluorene dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a dihydroxyfluorene + O2 = the corresponding 2-hydroxy-4-(oxo-1,3-dihydro-2H-inden-ylidene) but-2-enoic acid." [GOC:mah, UM-BBD_reactionID:r0415, UM-BBD_reactionID:r0422]
xref: EC:1.13.11.-
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0019118
name: phenanthrene-epoxide hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: a phenanthrene dioxide + H2O = a dihydrodiolphenanthrene." [GOC:mah, UM-BBD_reactionID:r0535, UM-BBD_reactionID:r0536]
xref: EC:3.3.2.-
is_a: GO:0004301 ! epoxide hydrolase activity

[Term]
id: GO:0019119
name: phenanthrene-9,10-epoxide hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9,10-dihydrodiolphenanthrene." [GOC:mah, UM-BBD_reactionID:r0496, UM-BBD_reactionID:r0560]
xref: EC:3.3.2.-
is_a: GO:0019118 ! phenanthrene-epoxide hydrolase activity

[Term]
id: GO:0019120
name: hydrolase activity, acting on acid halide bonds, in C-halide compounds
namespace: molecular_function
def: "Catalysis of the hydrolysis of any acid halide bond in substances containing halogen atoms in organic linkage." [ISBN:0198506732]
subset: gosubset_prok
xref: EC:3.8.1
is_a: GO:0016824 ! hydrolase activity, acting on acid halide bonds

[Term]
id: GO:0019121
name: peptidoglycan-protein cross-linking via N6-mureinyl-L-lysine
namespace: biological_process
def: "The process of linking a protein to peptidoglycan via the epsilon amino group of lysine to the diaminopimelic acid of the peptidoglycan." [RESID:AA0218]
subset: gosubset_prok
xref: RESID:AA0218
is_a: GO:0018104 ! peptidoglycan-protein cross-linking
is_a: GO:0018205 ! peptidyl-lysine modification

[Term]
id: GO:0019122
name: peptidyl-D-alanine racemization
namespace: biological_process
def: "The formation of peptidyl-D-alanine, by either racemization or from peptidyl-L-serine." [RESID:AA0191]
comment: See also the biological process terms 'peptidyl-D-alanine racemization, direct ; GO:0019916' and 'peptidyl-D-alanine racemization via peptidyl-L-serine ; GO:0019917'.
subset: gosubset_prok
synonym: "alanine racemization" BROAD []
xref: RESID:AA0191
is_a: GO:0018085 ! peptidyl-L-amino acid racemization
is_a: GO:0018194 ! peptidyl-alanine modification

[Term]
id: GO:0019123
name: peptidyl-methionine racemization
namespace: biological_process
alt_id: GO:0018087
alt_id: GO:0018369
def: "The racemization of peptidyl-methionine." [RESID:AA0193]
subset: gosubset_prok
xref: RESID:AA0193
is_a: GO:0018085 ! peptidyl-L-amino acid racemization

[Term]
id: GO:0019124
name: peptidyl-isoleucine racemization
namespace: biological_process
alt_id: GO:0018088
alt_id: GO:0018370
def: "The racemization of peptidyl-isoleucine." [RESID:AA0192]
subset: gosubset_prok
xref: RESID:AA0192
is_a: GO:0018085 ! peptidyl-L-amino acid racemization

[Term]
id: GO:0019125
name: peptidyl-phenylalanine racemization
namespace: biological_process
alt_id: GO:0018089
alt_id: GO:0018371
def: "The racemization of peptidyl-phenylalanine." [RESID:AA0194]
subset: gosubset_prok
xref: RESID:AA0194
is_a: GO:0018085 ! peptidyl-L-amino acid racemization

[Term]
id: GO:0019126
name: peptidyl-serine racemization
namespace: biological_process
alt_id: GO:0018090
alt_id: GO:0018372
def: "The racemization of peptidyl-serine." [RESID:AA0195]
subset: gosubset_prok
xref: RESID:AA0195
is_a: GO:0018085 ! peptidyl-L-amino acid racemization

[Term]
id: GO:0019128
name: peptidyl-tryptophan racemization
namespace: biological_process
alt_id: GO:0018092
alt_id: GO:0018374
def: "The racemization of peptidyl-tryptophan." [RESID:AA0198]
subset: gosubset_prok
xref: RESID:AA0198
is_a: GO:0018085 ! peptidyl-L-amino acid racemization

[Term]
id: GO:0019129
name: peptidyl-leucine racemization
namespace: biological_process
alt_id: GO:0018093
alt_id: GO:0018375
def: "The racemization of peptidyl-leucine." [RESID:AA0197]
subset: gosubset_prok
xref: RESID:AA0197
is_a: GO:0018085 ! peptidyl-L-amino acid racemization

[Term]
id: GO:0019131
name: obsolete tripeptidyl-peptidase I activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of an N-terminal tripeptide from a polypeptide; requires acid pH." [EC:3.4.14.9]
comment: This term was made obsolete because it represents a gene product.
synonym: "tripeptidyl aminopeptidase activity" BROAD [EC:3.4.14.9]
synonym: "tripeptidyl peptidase activity" BROAD [EC:3.4.14.9]
synonym: "tripeptidyl-peptidase I activity" EXACT []
xref: EC:3.4.14.9
xref: MetaCyc:3.4.14.9-RXN
is_obsolete: true
replaced_by: GO:0008240

[Term]
id: GO:0019132
name: obsolete C-terminal processing peptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of peptides after specific recognition of a C-terminal tripeptide, Xaa-Yaa-Zaa, in which Xaa is preferably Ala or Leu, Yaa is preferably Ala or Tyr, and Zaa is preferably Ala. Cleavage is at a variable distance from the C-terminus; a typical cleavage is -Ala-Ala-Arg-Ala-Ala-Lys-Glu-Asn-Tyr-Ala-Leu-Ala-Ala." [EC:3.4.21.102]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "C-terminal processing peptidase activity" EXACT []
synonym: "CtpA gene product (Synechocystis sp.)" RELATED [EC:3.4.21.102]
synonym: "photosystem II D1 protein processing peptidase" NARROW [EC:3.4.21.102]
synonym: "protease Re" RELATED [EC:3.4.21.102]
synonym: "tail-specific protease activity" EXACT [EC:3.4.21.102]
synonym: "Tsp protease" NARROW [EC:3.4.21.102]
xref: EC:3.4.21.102
xref: MetaCyc:3.4.21.102-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0019133
name: choline monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: choline + 2 reduced ferredoxin + O2 + 2 H+ = betaine aldehyde hydrate + 2 oxidized ferredoxin + H2O." [EC:1.14.15.7]
subset: gosubset_prok
synonym: "choline,reduced-ferredoxin:oxygen oxidoreductase activity" EXACT [EC:1.14.15.7]
xref: EC:1.14.15.7
xref: MetaCyc:RXN1F-357
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0019134
name: glucosamine-1-phosphate N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-glucosamine 1-phosphate + acetyl-CoA = N-acetyl-alpha-D-glucosamine 1-phosphate + CoA + H(+)." [EC:2.3.1.157, RHEA:13728]
subset: gosubset_prok
synonym: "acetyl-CoA:alpha-D-glucosamine-1-phosphate N-acetyltransferase activity" EXACT [EC:2.3.1.157]
synonym: "acetyl-CoA:D-glucosamine-1-phosphate N-acetyltransferase activity" EXACT [EC:2.3.1.157]
xref: EC:2.3.1.157
xref: KEGG:R05332
xref: MetaCyc:2.3.1.157-RXN
xref: RHEA:13728
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0019135
name: deoxyhypusine monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein N6-(4-aminobutyl)-L-lysine + donor-H2 + O2 = protein N6-((R)-4-amino-2-hydroxybutyl)-L-lysine + acceptor + H2O." [EC:1.14.99.29]
synonym: "deoxyhypusine dioxygenase activity" EXACT [EC:1.14.99.29]
synonym: "deoxyhypusine hydroxylase activity" EXACT []
synonym: "deoxyhypusine,hydrogen-donor:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.99.29]
synonym: "DOHH activity" EXACT [EC:1.14.99.29]
xref: EC:1.14.99.29
xref: MetaCyc:DEOXYHYPUSINE-MONOOXYGENASE-RXN
xref: Reactome:REACT_109540 "EIF5A(Dhp) + O2 => EIF5A(Hyp), Xenopus tropicalis"
xref: Reactome:REACT_110437 "EIF5A(Dhp) + O2 => EIF5A(Hyp), Saccharomyces cerevisiae"
xref: Reactome:REACT_110883 "EIF5A(Dhp) + O2 => EIF5A(Hyp), Bos taurus"
xref: Reactome:REACT_114901 "EIF5A(Dhp) + O2 => EIF5A(Hyp), Caenorhabditis elegans"
xref: Reactome:REACT_12479 "EIF5A(Dhp) + O2 => EIF5A(Hyp), Homo sapiens"
xref: Reactome:REACT_31020 "EIF5A(Dhp) + O2 => EIF5A(Hyp), Oryza sativa"
xref: Reactome:REACT_33236 "EIF5A(Dhp) + O2 => EIF5A(Hyp), Rattus norvegicus"
xref: Reactome:REACT_77539 "EIF5A(Dhp) + O2 => EIF5A(Hyp), Mus musculus"
xref: Reactome:REACT_77647 "EIF5A(Dhp) + O2 => EIF5A(Hyp), Schizosaccharomyces pombe"
xref: Reactome:REACT_77902 "EIF5A(Dhp) + O2 => EIF5A(Hyp), Gallus gallus"
xref: Reactome:REACT_78423 "EIF5A(Dhp) + O2 => EIF5A(Hyp), Sus scrofa"
xref: Reactome:REACT_82217 "EIF5A(Dhp) + O2 => EIF5A(Hyp), Dictyostelium discoideum"
xref: Reactome:REACT_82299 "EIF5A(Dhp) + O2 => EIF5A(Hyp), Canis familiaris"
xref: Reactome:REACT_89840 "EIF5A(Dhp) + O2 => EIF5A(Hyp), Danio rerio"
xref: Reactome:REACT_93081 "EIF5A(Dhp) + O2 => EIF5A(Hyp), Arabidopsis thaliana"
xref: Reactome:REACT_99954 "EIF5A(Dhp) + O2 => EIF5A(Hyp), Drosophila melanogaster"
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0019136
name: deoxynucleoside kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 2'-deoxynucleoside = ADP + 2'-deoxynucleoside 5'-phosphate." [EC:2.7.1.145]
subset: gosubset_prok
synonym: "ATP:deoxynucleoside 5'-phosphotransferase activity" EXACT [EC:2.7.1.145]
synonym: "D. melanogaster deoxynucleoside kinase activity" EXACT [EC:2.7.1.145]
synonym: "Dm-dNK" RELATED [EC:2.7.1.145]
synonym: "ms-dNK" RELATED [EC:2.7.1.145]
synonym: "Ms-dNK activity" RELATED [EC:2.7.1.145]
synonym: "multifunctional deoxynucleoside kinase activity" RELATED [EC:2.7.1.145]
synonym: "multispecific deoxynucleoside kinase activity" RELATED [EC:2.7.1.145]
synonym: "multisubstrate deoxyribonucleoside kinase activity" RELATED [EC:2.7.1.145]
xref: EC:2.7.1.145
xref: MetaCyc:2.7.1.145-RXN
is_a: GO:0019206 ! nucleoside kinase activity
relationship: part_of GO:0009157 ! deoxyribonucleoside monophosphate biosynthetic process

[Term]
id: GO:0019137
name: thioglucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a thioglucoside + H2O = a thiol + a sugar." [EC:3.2.1.147]
synonym: "myrosinase activity" EXACT []
synonym: "sinigrase activity" EXACT []
synonym: "sinigrinase activity" EXACT []
synonym: "thioglucoside glucohydrolase activity" EXACT []
xref: EC:3.2.1.147
xref: MetaCyc:RXN-9946
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0019139
name: cytokinin dehydrogenase activity
namespace: molecular_function
alt_id: GO:0046420
def: "Catalysis of the reaction: N6-dimethylallyladenine + acceptor + H2O = adenine + 3-methylbut-2-enal + reduced electron acceptor." [EC:1.5.99.12]
synonym: "6-N-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [EC:1.5.99.12]
synonym: "cytokinin oxidase activity" RELATED []
synonym: "N6-dimethylallyladenine:(acceptor) oxidoreductase activity" EXACT [EC:1.5.99.12]
synonym: "N6-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [EC:1.5.99.12]
xref: EC:1.5.99.12
xref: MetaCyc:1.5.99.12-RXN
xref: MetaCyc:PWY-2841
xref: RHEA:13628
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0019140
name: inositol 3-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + myo-inositol = ADP + 1D-myo-inositol 3-phosphate." [EC:2.7.1.64]
synonym: "ATP:myo-inositol 1-phosphotransferase activity" EXACT [EC:2.7.1.64]
synonym: "inositol 1-kinase activity" RELATED [EC:2.7.1.64]
synonym: "inositol-1-kinase (phosphorylating)" EXACT [EC:2.7.1.64]
synonym: "myo-inositol 1-kinase activity" RELATED [EC:2.7.1.64]
synonym: "myo-inositol 3-kinase activity" EXACT []
synonym: "myoinositol kinase activity" BROAD [EC:2.7.1.64]
xref: EC:2.7.1.64
xref: MetaCyc:MYO-INOSITOL-1-KINASE-RXN
xref: RHEA:21807
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0019141
name: 2-dehydropantolactone reductase (B-specific) activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NADP+." [EC:1.1.1.214]
synonym: "(R)-pantolactone:NADP+ oxidoreductase (B-specific)" EXACT [EC:1.1.1.214]
synonym: "2-dehydropantoyl-lactone reductase (B-specific) activity" EXACT []
synonym: "2-ketopantoyl lactone reductase activity" BROAD [EC:1.1.1.214]
synonym: "2-oxopantoyl lactone reductase" BROAD [EC:1.1.1.214]
synonym: "ketopantoyl lactone reductase activity" BROAD [EC:1.1.1.214]
xref: EC:1.1.1.214
xref: MetaCyc:DEHYDROPANTLACRED-RXN
is_a: GO:0036441 ! 2-dehydropantolactone reductase activity

[Term]
id: GO:0019142
name: 2-hydroxyglutarate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: glyoxylate + H(2)O + propanoyl-CoA = 2-hydroxyglutarate + CoA + H(+)." [EC:2.3.3.11, RHEA:19188]
comment: Note that this function was formerly EC:4.1.3.9.
synonym: "2-hydroxyglutarate glyoxylate-lyase (CoA-propanoylating) activity" EXACT [EC:2.3.3.11]
synonym: "2-hydroxyglutaratic synthetase activity" EXACT [EC:2.3.3.11]
synonym: "2-hydroxyglutaric synthetase activity" EXACT [EC:2.3.3.11]
synonym: "alpha-hydroxyglutarate synthase activity" EXACT [EC:2.3.3.11]
synonym: "hydroxyglutarate synthase activity" EXACT [EC:2.3.3.11]
synonym: "propanoyl-CoA:glyoxylate C-propanoyltransferase (thioester-hydrolysing, 2-carboxyethyl-forming)" EXACT [EC:2.3.3.11]
xref: EC:2.3.3.11
xref: KEGG:R00932
xref: MetaCyc:HYDGLUTSYN-RXN
xref: RHEA:19188
is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

[Term]
id: GO:0019143
name: 3-deoxy-manno-octulosonate-8-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 8-phospho-3-deoxy-D-manno-oct-2-ulosonate + H(2)O = 3-deoxy-D-manno-octulosonate + phosphate." [EC:3.1.3.45, RHEA:11503]
subset: gosubset_prok
synonym: "3-deoxy-D-manno-octulosonate-8-phosphate 8-phosphohydrolase activity" EXACT [EC:3.1.3.45]
xref: EC:3.1.3.45
xref: KEGG:R03350
xref: MetaCyc:KDO-8PPHOSPHAT-RXN
xref: RHEA:11503
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0019144
name: ADP-sugar diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: ADP-sugar + H2O = AMP + sugar 1-phosphate." [EC:3.6.1.21]
subset: gosubset_prok
synonym: "adenosine diphosphosugar pyrophosphatase activity" EXACT [EC:3.6.1.21]
synonym: "ADP-sugar pyrophosphatase activity" EXACT [EC:3.6.1.21]
synonym: "ADP-sugar sugarphosphohydrolase activity" EXACT [EC:3.6.1.21]
synonym: "ADPsugar pyrophosphatase activity" EXACT [EC:3.6.1.21]
synonym: "nucleoside diphosphate-sugar hydrolase activity" BROAD [GOC:vw]
xref: EC:3.6.1.21
xref: MetaCyc:ADPSUGPPHOSPHAT-RXN
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0019145
name: aminobutyraldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-aminobutanal + NAD+ + H2O = 4-aminobutanoate + NADH + 2 H+." [EC:1.2.1.19]
subset: gosubset_prok
synonym: "4-aminobutanal dehydrogenase activity" EXACT [EC:1.2.1.19]
synonym: "4-aminobutanal:NAD+ 1-oxidoreductase activity" EXACT [EC:1.2.1.19]
synonym: "4-aminobutyraldehyde dehydrogenase activity" EXACT [EC:1.2.1.19]
synonym: "ABAL dehydrogenase activity" EXACT [EC:1.2.1.19]
synonym: "gamma-aminobutyraldehyde dehydroganase activity" EXACT [EC:1.2.1.19]
xref: EC:1.2.1.19
xref: MetaCyc:AMINOBUTDEHYDROG-RXN
xref: RHEA:19108
is_a: GO:0004029 ! aldehyde dehydrogenase (NAD) activity

[Term]
id: GO:0019146
name: arabinose-5-phosphate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-arabinose 5-phosphate = D-ribulose 5-phosphate + 2 H(+)." [EC:5.3.1.13, RHEA:23107]
subset: gosubset_prok
synonym: "arabinose phosphate isomerase activity" EXACT [EC:5.3.1.13]
synonym: "D-arabinose-5-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.13]
synonym: "D-arabinose-5-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.13]
synonym: "phosphoarabinoisomerase activity" EXACT [EC:5.3.1.13]
xref: EC:5.3.1.13
xref: KEGG:R01530
xref: MetaCyc:DARAB5PISOM-RXN
xref: RHEA:23107
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0019147
name: (R)-aminopropanol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-1-aminopropan-2-ol + NAD(+) = aminoacetone + H(+) + NADH." [EC:1.1.1.75, RHEA:16520]
synonym: "(R)-1-aminopropan-2-ol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.75]
synonym: "1-aminopropan-2-ol-dehydrogenase activity" EXACT [EC:1.1.1.75]
synonym: "1-aminopropan-2-ol-NAD+ dehydrogenase activity" EXACT [EC:1.1.1.75]
synonym: "DL-1-aminopropan-2-ol: NAD+ dehydrogenase activity" EXACT [EC:1.1.1.75]
synonym: "L(+)-1-aminopropan-2-ol-NAD/NADP oxidoreductase activity" EXACT [EC:1.1.1.75]
synonym: "L(+)-1-aminopropan-2-ol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.75]
synonym: "L-aminopropanol dehydrogenase activity" EXACT []
xref: EC:1.1.1.75
xref: KEGG:R03759
xref: MetaCyc:AMINOPROPDEHYDROG-RXN
xref: RHEA:16520
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0019148
name: D-cysteine desulfhydrase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-cysteine + H2O = sulfide + NH3 + pyruvate." [EC:4.4.1.15]
subset: gosubset_prok
synonym: "D-cysteine lyase activity" EXACT [EC:4.4.1.15]
synonym: "D-cysteine sulfide-lyase (deaminating)" EXACT [EC:4.4.1.15]
synonym: "D-cysteine sulfide-lyase (deaminating; pyruvate-forming)" EXACT [EC:4.4.1.15]
xref: EC:4.4.1.15
xref: MetaCyc:DCYSDESULF-RXN
xref: RHEA:11271
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0019149
name: 3-chloro-D-alanine dehydrochlorinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-chloro-D-alanine + H2O = pyruvate + chloride + NH3." [EC:4.5.1.2]
synonym: "3-chloro-D-alanine chloride-lyase (deaminating)" EXACT [EC:4.5.1.2]
synonym: "3-chloro-D-alanine chloride-lyase (deaminating; pyruvate-forming)" EXACT [EC:4.5.1.2]
synonym: "beta-chloro-D-alanine dehydrochlorinase activity" EXACT [EC:4.5.1.2]
xref: EC:4.5.1.2
xref: MetaCyc:3-CHLORO-D-ALANINE-DEHYDROCHLORINASE-RXN
xref: RHEA:18876
is_a: GO:0016848 ! carbon-halide lyase activity

[Term]
id: GO:0019150
name: D-ribulokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-ribulose = ADP + D-ribulose 5-phosphate." [EC:2.7.1.47]
subset: gosubset_prok
synonym: "ATP:D-ribulose 5-phosphotransferase activity" EXACT [EC:2.7.1.47]
synonym: "D-ribulokinase (phosphorylating)" EXACT [EC:2.7.1.47]
xref: EC:2.7.1.47
xref: MetaCyc:D-RIBULOKIN-RXN
xref: RHEA:17604
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0019151
name: galactose 1-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-galactose + NAD+ = D-galactono-1,4-lactone + NADH + H+." [EC:1.1.1.48]
subset: gosubset_prok
synonym: "beta-galactose dehydrogenase activity" EXACT [EC:1.1.1.48]
synonym: "D-galactose 1-dehydrogenase activity" EXACT []
synonym: "D-galactose dehydrogenase activity" EXACT [EC:1.1.1.48]
synonym: "D-galactose:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.48]
synonym: "NAD-dependent D-galactose dehydrogenase activity" EXACT [EC:1.1.1.48]
xref: EC:1.1.1.48
xref: MetaCyc:GALACTODEHYDROG-RXN
xref: RHEA:21299
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0019152
name: acetoin dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetoin + NAD+ = diacetyl + NADH + H+." [MetaCyc:ACETOINDEHYDROG-RXN]
subset: gosubset_prok
synonym: "diacetyl reductase activity" EXACT [EC:1.1.1.5]
xref: EC:1.1.1.-
xref: KEGG:R02343
xref: MetaCyc:ACETOINDEHYDROG-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0019153
name: protein-disulfide reductase (glutathione) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 glutathione + protein-disulfide = oxidized glutathione + protein-dithiol." [EC:1.8.4.2]
subset: gosubset_prok
synonym: "glutaredoxin reductase" RELATED []
synonym: "glutathione--insulin transhydrogenase activity" EXACT [EC:1.8.4.2]
synonym: "glutathione-insulin transhydrogenase activity" EXACT []
synonym: "glutathione-protein disulfide oxidoreductase activity" EXACT [EC:1.8.4.2]
synonym: "glutathione:protein-disulfide oxidoreductase activity" EXACT [EC:1.8.4.2]
synonym: "GSH-insulin transhydrogenase activity" EXACT [EC:1.8.4.2]
synonym: "insulin reductase activity" EXACT [EC:1.8.4.2]
synonym: "protein disulfide reductase (glutathione)" EXACT [EC:1.8.4.2]
synonym: "protein disulfide transhydrogenase activity" EXACT [EC:1.8.4.2]
synonym: "protein-disulfide interchange enzyme" RELATED [EC:1.8.4.2]
synonym: "protein-disulfide isomerase/oxidoreductase activity" EXACT [EC:1.8.4.2]
synonym: "protein-disulphide reductase (glutathione) activity" EXACT []
synonym: "reductase, protein disulfide (glutathione)" EXACT [EC:1.8.4.2]
synonym: "thiol-protein disulphide oxidoreductase activity" EXACT [EC:1.8.4.2]
synonym: "thiol:protein-disulfide oxidoreductase activity" EXACT [EC:1.8.4.2]
xref: EC:1.8.4.2
xref: MetaCyc:PRODISULFREDUCT-RXN
xref: RHEA:21067
is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor

[Term]
id: GO:0019154
name: glycolate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: A + glycolate = AH(2) + glyoxylate." [EC:1.1.99.14, RHEA:21267]
synonym: "glycolate oxidoreductase activity" EXACT [EC:1.1.99.14]
synonym: "glycolate:(acceptor) 2-oxidoreductase activity" EXACT [EC:1.1.99.14]
synonym: "glycolate:acceptor 2-oxidoreductase activity" EXACT [EC:1.1.99.14]
synonym: "glycolic acid dehydrogenase activity" EXACT [EC:1.1.99.14]
xref: EC:1.1.99.14
xref: KEGG:R00476
xref: MetaCyc:GLYCOLATEDEHYDRO-RXN
xref: RHEA:21267
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0019155
name: 3-(imidazol-5-yl)lactate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-3-(imidazol-5-yl)lactate + NADP+ = 3-(imidazol-5-yl)pyruvate + NADPH + H+." [EC:1.1.1.111]
synonym: "(S)-3-(imidazol-5-yl)lactate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.111]
synonym: "imidazol-5-yl lactate dehydrogenase activity" EXACT [EC:1.1.1.111]
xref: EC:1.1.1.111
xref: MetaCyc:IMILACTDEHYDROG-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0019156
name: isoamylase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages in glycogen, amylopectin and their beta-limits dextrins." [EC:3.2.1.68]
subset: gosubset_prok
synonym: "debranching enzyme activity" BROAD [EC:3.2.1.68]
synonym: "glycogen alpha-1,6-glucanohydrolase activity" EXACT [EC:3.2.1.68]
xref: EC:3.2.1.68
xref: MetaCyc:3.2.1.68-RXN
is_a: GO:0004133 ! glycogen debranching enzyme activity
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0019157
name: malate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-malate + O(2) = H(2)O(2) + oxaloacetate." [EC:1.1.3.3, RHEA:10515]
synonym: "(S)-malate:oxygen oxidoreductase activity" EXACT [EC:1.1.3.3]
synonym: "FAD-dependent malate oxidase activity" EXACT [EC:1.1.3.3]
synonym: "malic dehydrogenase II" RELATED [EC:1.1.3.3]
synonym: "malic oxidase activity" EXACT [EC:1.1.3.3]
xref: EC:1.1.3.3
xref: KEGG:R00360
xref: MetaCyc:MALOX-RXN
xref: RHEA:10515
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0019158
name: mannokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-mannose = ADP + D-mannose 6-phosphate." [EC:2.7.1.7]
subset: gosubset_prok
synonym: "ATP:D-mannose 6-phosphotransferase activity" EXACT [EC:2.7.1.7]
synonym: "D-fructose (D-mannose) kinase activity" EXACT [EC:2.7.1.7]
synonym: "mannokinase (phosphorylating)" EXACT [EC:2.7.1.7]
xref: EC:2.7.1.7
xref: MetaCyc:MANNKIN-RXN
xref: RHEA:11031
is_a: GO:0004396 ! hexokinase activity

[Term]
id: GO:0019159
name: nicotinamide-nucleotide amidase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-nicotinamide D-ribonucleotide + H2O = beta-nicotinate D-ribonucleotide + NH3." [EC:3.5.1.42]
synonym: "nicotinamide mononucleotide amidohydrolase activity" EXACT [EC:3.5.1.42]
synonym: "nicotinamide mononucleotide deamidase activity" EXACT [EC:3.5.1.42]
synonym: "nicotinamide-D-ribonucleotide amidohydrolase activity" EXACT [EC:3.5.1.42]
synonym: "NMN amidohydrolase" NARROW []
synonym: "NMN deamidase activity" EXACT [EC:3.5.1.42]
xref: EC:3.5.1.42
xref: MetaCyc:NMNAMIDOHYDRO-RXN
xref: RHEA:12403
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0019160
name: NMN nucleosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + nicotinamide mononucleotide = D-ribose 5-phosphate + H(+) + nicotinamide." [EC:3.2.2.14, RHEA:23143]
synonym: "nicotinamide mononucleotidase activity" EXACT [EC:3.2.2.14]
synonym: "nicotinamide mononucleotide nucleosidase activity" EXACT [EC:3.2.2.14]
synonym: "nicotinamide-nucleotide phosphoribohydrolase activity" EXACT [EC:3.2.2.14]
synonym: "NMN glycohydrolase activity" EXACT [EC:3.2.2.14]
synonym: "NMNase activity" EXACT [EC:3.2.2.14]
synonym: "NMNGhase activity" EXACT [EC:3.2.2.14]
xref: EC:3.2.2.14
xref: KEGG:R01270
xref: MetaCyc:NMNNUCLEOSID-RXN
xref: RHEA:23143
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0019161
name: diamine transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: an alpha,omega-diamine + 2-oxoglutarate = an omega-aminoaldehyde + L-glutamate." [EC:2.6.1.29]
synonym: "amine transaminase activity" EXACT [EC:2.6.1.29]
synonym: "amine-ketoacid transaminase activity" EXACT [EC:2.6.1.29]
synonym: "diamine aminotransferase activity" EXACT []
synonym: "diamine-ketoglutaric transaminase activity" EXACT [EC:2.6.1.29]
synonym: "diamine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.29]
xref: EC:2.6.1.29
xref: MetaCyc:DIAMTRANSAM-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0019162
name: pyridoxamine-oxaloacetate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: oxaloacetate + pyridoxamine = L-aspartate + pyridoxal." [EC:2.6.1.31, RHEA:10847]
synonym: "pyridoxamine--oxaloacetate aminotransferase activity" EXACT [EC:2.6.1.31]
synonym: "pyridoxamine-oxaloacetate aminotransferase activity" EXACT []
synonym: "pyridoxamine:oxaloacetate aminotransferase activity" EXACT [EC:2.6.1.31]
xref: EC:2.6.1.31
xref: KEGG:R01713
xref: MetaCyc:PYROXALTRANSAM-RXN
xref: RHEA:10847
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0019163
name: pyridoxamine-phosphate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyridoxamine 5'-phosphate + 2-oxoglutarate = pyridoxal 5'-phosphate + D-glutamate." [EC:2.6.1.54]
synonym: "pyridoxamine 5'-phosphate transaminase activity" EXACT [EC:2.6.1.54]
synonym: "pyridoxamine 5'-phosphate-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.54]
synonym: "pyridoxamine phosphate aminotransferase activity" EXACT [EC:2.6.1.54]
synonym: "pyridoxamine-5'-phosphate:2-oxoglutarate aminotransferase (D-glutamate-forming)" EXACT [EC:2.6.1.54]
synonym: "pyridoxamine-phosphate aminotransferase activity" EXACT []
xref: EC:2.6.1.54
xref: MetaCyc:PYRDAMPTRANS-RXN
xref: RHEA:15880
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0019164
name: pyruvate synthase activity
namespace: molecular_function
alt_id: GO:0018696
def: "Catalysis of the reaction: pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+." [KEGG:R01196]
subset: gosubset_prok
synonym: "PFOR" EXACT []
synonym: "pyruvate oxidoreductase activity" EXACT [EC:1.2.7.1]
synonym: "pyruvate synthetase activity" EXACT [EC:1.2.7.1]
synonym: "pyruvate-ferredoxin reductase activity" EXACT []
synonym: "pyruvate:ferredoxin 2-oxidoreductase (CoA-acetylating)" EXACT [EC:1.2.7.1]
synonym: "pyruvate:ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.1]
synonym: "pyruvic-ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.1]
xref: EC:1.2.7.1
xref: KEGG:R01196
xref: MetaCyc:PYRUFLAVREDUCT-RXN
is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor
relationship: part_of GO:0006086 ! acetyl-CoA biosynthetic process from pyruvate

[Term]
id: GO:0019165
name: thiamine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + thiamine = ADP + 2 H(+) + thiamine phosphate." [EC:2.7.1.89, RHEA:12015]
synonym: "ATP:thiamin phosphotransferase activity" EXACT [EC:2.7.1.89]
synonym: "ATP:thiamine phosphotransferase activity" EXACT [EC:2.7.1.89]
synonym: "thiamin kinase (phosphorylating)" EXACT [EC:2.7.1.89]
synonym: "thiamin kinase activity" EXACT [EC:2.7.1.89]
synonym: "thiamin phosphokinase activity" EXACT [EC:2.7.1.89]
xref: EC:2.7.1.89
xref: KEGG:R02134
xref: MetaCyc:THIKIN-RXN
xref: RHEA:12015
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0019166
name: trans-2-enoyl-CoA reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH + H+." [EC:1.3.1.38]
synonym: "acyl-CoA:NADP+ trans-2-oxidoreductase activity" EXACT [EC:1.3.1.38]
synonym: "NADPH-dependent trans-2-enoyl-CoA reductase activity" EXACT [EC:1.3.1.38]
synonym: "reductase, trans-enoyl coenzyme A" EXACT [EC:1.3.1.38]
xref: EC:1.3.1.38
xref: MetaCyc:TRANSENOYLCOARED-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0019168
name: 2-octaprenylphenol hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-octaprenylphenol + NADPH + O2 + H+ = 2-octaprenyl-6-hydroxyphenol + NADP+ + H2O." [MetaCyc:2-OCTAPRENYLPHENOL-HYDROX-RXN]
xref: MetaCyc:2-OCTAPRENYLPHENOL-HYDROX-RXN
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0019170
name: methylglyoxal reductase (NADH-dependent) activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-lactaldehyde + NAD+ = methylglyoxal + NADH + H+." [EC:1.1.1.78]
synonym: "(R)-lactaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.78]
synonym: "D-lactaldehyde dehydrogenase activity" EXACT []
synonym: "methylglyoxal reductase activity" EXACT []
xref: EC:1.1.1.78
xref: MetaCyc:D-LACTALDEHYDE-DEHYDROGENASE-RXN
xref: RHEA:24531
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0019171
name: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: a (3R)-3-hydroxyacyl-[acyl-carrier protein] = H2O + a trans-delta2-enoyl-acyl-[acyl-carrier protein]." [MetaCyc:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN]
subset: gosubset_prok
synonym: "3-hydroxyacyl-[acyl-carrier protein] dehydratase activity" EXACT []
synonym: "3-hydroxyacyl-ACP dehydratase activity" EXACT []
xref: EC:4.2.1.59
xref: MetaCyc:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0019172
name: glyoxalase III activity
namespace: molecular_function
def: "Catalysis of the reaction: methylglyoxal + H2O = D-lactate." [EC:4.2.1.130, GOC:mcc, http://www.brenda-enzymes.org/php/result_flat.php4?ecno=4.2.1.130, MetaCyc:GLYOXIII-RXN, PMID:21696459, PMID:7848303, RHEA:27757]
comment: Note that this term was reinstated from obsolete. Also note that this enzymatic activity converts methylglyoxal to D-lactate in a single glutathione (GSH)-independent step. The other known route for this conversion is the two-step GSH-dependent pathway catalyzed by EC 4.4.1.5 (lactoylglutathione lyase) and EC 3.1.2.6 (hydroxyacylglutathione hydrolase).
synonym: "(R)-lactate hydro-lyase" EXACT []
synonym: "D-lactate dehydratase" EXACT []
synonym: "glutathione-independent glyoxalase activity" RELATED []
xref: MetaCyc:GLYOXIII-RXN
xref: RHEA:27754
is_a: GO:0016836 ! hydro-lyase activity
relationship: part_of GO:0019249 ! lactate biosynthetic process
relationship: part_of GO:0061727 ! methylglyoxal catabolic process to lactate

[Term]
id: GO:0019174
name: tetrahydrothiophene 1-oxide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: tetrahydrothiophene 1-oxide + reduced acceptor = tetrahydrothiophene + acceptor." [MetaCyc:THTOREDUCT-RXN]
xref: MetaCyc:THTOREDUCT-RXN
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0019176
name: dihydroneopterin monophosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: dihydroneopterin monophosphate = dihydroneopterin + phosphate." [MetaCyc:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN]
synonym: "dihydroneopterin monophosphate dephosphorylase activity" EXACT []
xref: EC:3.6.1.-
xref: MetaCyc:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN
is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

[Term]
id: GO:0019177
name: dihydroneopterin triphosphate pyrophosphohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: dihydroneopterin triphosphate = dihydroneopterin phosphate + diphosphate." [MetaCyc:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN]
xref: EC:3.6.1.-
xref: MetaCyc:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0019178
name: NADP phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + NADP+ = NAD+ + phosphate." [MetaCyc:NADPPHOSPHAT-RXN]
xref: EC:3.1.3.-
xref: MetaCyc:NADPPHOSPHAT-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0019179
name: dTDP-4-amino-4,6-dideoxy-D-glucose transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: dTDP-4-amino-4,6-dideoxy-D-glucose + 2-oxoglutarate = dTDP-4-dehydro-6-deoxy-D-glucose + L-glutamate." [EC:2.6.1.33]
synonym: "dTDP-4-amino-4,6-dideoxy-D-glucose aminotransferase activity" EXACT []
synonym: "dTDP-4-amino-4,6-dideoxy-D-glucose:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.33]
synonym: "TDP-4-keto-6-deoxy-D-glucose transaminase activity" EXACT [EC:2.6.1.33]
synonym: "TDP-4-oxo-6-deoxy-D-glucose transaminase activity" EXACT [EC:2.6.1.33]
synonym: "thymidine diphospho-4-amino-4,6-dideoxyglucose aminotransferase activity" EXACT [EC:2.6.1.33]
synonym: "thymidine diphospho-4-amino-6-deoxyglucose aminotransferase activity" EXACT [EC:2.6.1.33]
synonym: "thymidine diphospho-4-keto-6-deoxy-D-glucose transaminase activity" EXACT [EC:2.6.1.33]
synonym: "thymidine diphospho-4-keto-6-deoxy-D-glucose-glutamic transaminase activity" EXACT [EC:2.6.1.33]
xref: EC:2.6.1.33
xref: MetaCyc:2.6.1.33-RXN
xref: RHEA:19088
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0019180
name: dTDP-4-amino-4,6-dideoxygalactose transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-galactose = L-glutamate + dTDP-4-dehydro-6-deoxy-D-galactose." [EC:2.6.1.59, RHEA:10371]
synonym: "dTDP-4,6-dideoxy-D-galactose:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.59]
synonym: "dTDP-4-amino-4,6-dideoxygalactose aminotransferase activity" EXACT [EC:2.6.1.59]
synonym: "dTDP-fucosamine aminotransferase activity" EXACT []
synonym: "thymidine diphosphate 4-keto-6-deoxy-D-glucose transaminase activity" EXACT [EC:2.6.1.59]
synonym: "thymidine diphosphoaminodideoxygalactose aminotransferase activity" EXACT [EC:2.6.1.59]
xref: EC:2.6.1.59
xref: KEGG:R04438
xref: MetaCyc:2.6.1.59-RXN
xref: RHEA:10371
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0019181
name: halohydrin hydrogen-halide-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: a halohydrin = an epoxide + a hydrogen halide." [PMID:8017917]
xref: EC:4.5.1.-
is_a: GO:0016848 ! carbon-halide lyase activity

[Term]
id: GO:0019182
name: histamine-gated chloride channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a chloride ion by a channel that opens when histamine has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0005254 ! chloride channel activity
is_a: GO:0015276 ! ligand-gated ion channel activity

[Term]
id: GO:0019183
name: histamine-gated chloride channel complex
namespace: cellular_component
def: "A protein complex that forms a transmembrane channel through which chloride ions may pass in response to histamine binding to the channel complex or one of its constituent parts." [GOC:mah]
is_a: GO:0034707 ! chloride channel complex
is_a: GO:0098802 ! plasma membrane receptor complex
relationship: part_of GO:0005887 ! integral component of plasma membrane

[Term]
id: GO:0019184
name: nonribosomal peptide biosynthetic process
namespace: biological_process
def: "The biosynthetic process in which peptide bond formation occurs in the absence of the translational machinery. Examples include the synthesis of antibiotic peptides, and glutathione." [ISBN:0198506732]
subset: gosubset_prok
synonym: "non-ribosomal peptide biosynthesis" EXACT []
synonym: "non-ribosomal peptide biosynthetic process" EXACT []
synonym: "non-ribosomal peptide formation" EXACT []
synonym: "non-ribosomal peptide synthesis" EXACT []
synonym: "nonribosomal peptide anabolism" EXACT []
synonym: "nonribosomal peptide biosynthesis" EXACT []
synonym: "nonribosomal peptide formation" EXACT []
synonym: "nonribosomal peptide synthesis" EXACT []
synonym: "nonribosomal peptide synthetase" RELATED []
is_a: GO:0043043 ! peptide biosynthetic process

[Term]
id: GO:0019185
name: snRNA-activating protein complex
namespace: cellular_component
def: "A protein complex that recognizes the proximal sequence element of RNA polymerase II and III snRNA promoters." [PMID:7715707, PMID:9003788]
synonym: "SNAPc" EXACT []
is_a: GO:0044798 ! nuclear transcription factor complex

[Term]
id: GO:0019186
name: acyl-CoA N-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an acyl group from acyl-CoA to a nitrogen atom on an acceptor molecule." [GOC:mah]
xref: EC:2.3.1.-
is_a: GO:0016410 ! N-acyltransferase activity

[Term]
id: GO:0019187
name: beta-1,4-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a mannose residue to an oligosaccharide, forming a beta-(1->4) linkage." [GOC:mcc, PMID:8166646]
xref: EC:2.4.1.-
is_a: GO:0000030 ! mannosyltransferase activity

[Term]
id: GO:0019191
name: cellobiose transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0019190
def: "Enables the transfer of cellobiose from one side of the membrane to the other. Cellobiose, or 4-O-beta-D-glucopyranosyl-D-glucose, is a disaccharide that represents the basic repeating unit of cellulose." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
subset: gosubset_prok
synonym: "cellobiose permease activity" EXACT []
is_a: GO:0015154 ! disaccharide transmembrane transporter activity
relationship: part_of GO:0019533 ! cellobiose transport

[Term]
id: GO:0019194
name: sorbose transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0019193
def: "Enables the transfer of sorbose from one side of the membrane to the other. Sorbose is the ketohexose xylo-2-hexulose; L-sorbose is formed by bacterial oxidation of sorbitol. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "sorbose porter activity" EXACT []
is_a: GO:0015149 ! hexose transmembrane transporter activity

[Term]
id: GO:0019196
name: galactosamine transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0019195
def: "Enables the transfer of galactosamine from one side of the membrane to the other. Galactosamine is an aminodeoxysugar; D-galactosamine is a constituent of some glycolipids and glycosaminoglycans, commonly as its N-acetyl derivative." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
synonym: "galactosamine porter activity" EXACT []
is_a: GO:0022857 ! transmembrane transporter activity
is_a: GO:1901505 ! carbohydrate derivative transporter activity

[Term]
id: GO:0019197
name: phosphoenolpyruvate-dependent sugar phosphotransferase complex
namespace: cellular_component
def: "Includes phosphoenolpyruvate-protein phosphatase (enzyme I of the phosphotransferase system) and protein-N(PI)-phosphohistidine-sugar phosphotransferase (enzyme II of the phosphotransferase system)." [GOC:ma]
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0019198
name: transmembrane receptor protein phosphatase activity
namespace: molecular_function
def: "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate." [GOC:hjd]
xref: EC:3.1.3.-
is_a: GO:0004721 ! phosphoprotein phosphatase activity
is_a: GO:0004888 ! transmembrane signaling receptor activity

[Term]
id: GO:0019199
name: transmembrane receptor protein kinase activity
namespace: molecular_function
def: "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP." [GOC:mah]
subset: gosubset_prok
xref: EC:2.7.11.-
is_a: GO:0004672 ! protein kinase activity
is_a: GO:0004888 ! transmembrane signaling receptor activity

[Term]
id: GO:0019200
name: carbohydrate kinase activity
namespace: molecular_function
def: "Catalysis of the transfer of a phosphate group, usually from ATP, to a carbohydrate substrate molecule." [GOC:jl]
subset: gosubset_prok
is_a: GO:0016301 ! kinase activity
relationship: part_of GO:0046835 ! carbohydrate phosphorylation

[Term]
id: GO:0019201
name: nucleotide kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + nucleoside monophosphate = ADP + nucleoside diphosphate." [GOC:ai, ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0019205 ! nucleobase-containing compound kinase activity
relationship: part_of GO:0046939 ! nucleotide phosphorylation

[Term]
id: GO:0019202
name: amino acid kinase activity
namespace: molecular_function
def: "Catalysis of the transfer of a phosphate group, usually from ATP, to an amino acid substrate." [GOC:jl]
subset: gosubset_prok
is_a: GO:0016301 ! kinase activity

[Term]
id: GO:0019203
name: carbohydrate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: carbohydrate phosphate + H2O = carbohydrate + phosphate." [GOC:mah]
subset: gosubset_prok
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0019204
name: obsolete nucleotide phosphatase activity
namespace: molecular_function
def: "OBSOLETE: Catalysis of the reaction: phosphopolynucleotide + H2O = polynucleotide + phosphate." [GOC:mah]
comment: This term was defined to cover phosphatase activity against polynucleotides, but had subclasses and annotations for phosphatase activity against free nucleotides.  It has therefore been split. Use GO:0098519 (nucleotide phosphatase activity, acting against free nucleotides) or GO:0098518 (polynucleotide phosphatase activity).
synonym: "nucleotide phosphatase activity" EXACT []
is_obsolete: true
consider: GO:0098518
consider: GO:0098519

[Term]
id: GO:0019205
name: nucleobase-containing compound kinase activity
namespace: molecular_function
def: "Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate." [GOC:jl]
subset: gosubset_prok
synonym: "nucleobase, nucleoside, nucleotide kinase activity" RELATED [GOC:dph, GOC:tb]
is_a: GO:0016301 ! kinase activity

[Term]
id: GO:0019206
name: nucleoside kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + nucleoside = ADP + nucleoside monophosphate." [GOC:ai]
subset: gosubset_prok
xref: Reactome:REACT_100134 "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2], Sus scrofa"
xref: Reactome:REACT_100206 "(2'-deoxy)cytidine + ATP => (d)CMP + ADP [DCK], Mus musculus"
xref: Reactome:REACT_100437 "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1], Mus musculus"
xref: Reactome:REACT_100462 "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2], Xenopus tropicalis"
xref: Reactome:REACT_102022 "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1], Bos taurus"
xref: Reactome:REACT_102959 "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1], Danio rerio"
xref: Reactome:REACT_103604 "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1], Canis familiaris"
xref: Reactome:REACT_103859 "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP [AK5], Mus musculus"
xref: Reactome:REACT_104116 "(d)AMP or (d)CMP + ATP <=> (d)ADP or (d)CDP + ADP [AK5], Taeniopygia guttata"
xref: Reactome:REACT_105485 "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP [DGUOK], Canis familiaris"
xref: Reactome:REACT_106040 "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1], Caenorhabditis elegans"
xref: Reactome:REACT_106610 "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1], Mus musculus"
xref: Reactome:REACT_106632 "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2], Taeniopygia guttata"
xref: Reactome:REACT_107819 "(d)AMP or (d)CMP + ATP <=> (d)ADP or (d)CDP + ADP [AK5], Sus scrofa"
xref: Reactome:REACT_108247 "(d)AMP or (d)CMP + ATP <=> (d)ADP or (d)CDP + ADP [AK5], Bos taurus"
xref: Reactome:REACT_108761 "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP [AK5], Sus scrofa"
xref: Reactome:REACT_108769 "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1], Dictyostelium discoideum"
xref: Reactome:REACT_109347 "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP [DGUOK], Taeniopygia guttata"
xref: Reactome:REACT_109993 "(2'-deoxy)cytidine + ATP => (d)CMP + ADP [DCK], Xenopus tropicalis"
xref: Reactome:REACT_110011 "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2], Rattus norvegicus"
xref: Reactome:REACT_110013 "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP [AK5], Bos taurus"
xref: Reactome:REACT_110052 "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP [DGUOK], Danio rerio"
xref: Reactome:REACT_110054 "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2], Gallus gallus"
xref: Reactome:REACT_110429 "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2], Danio rerio"
xref: Reactome:REACT_110949 "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1], Canis familiaris"
xref: Reactome:REACT_110974 "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP [DCK], Arabidopsis thaliana"
xref: Reactome:REACT_112294 "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP [AK5], Caenorhabditis elegans"
xref: Reactome:REACT_112710 "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1], Dictyostelium discoideum"
xref: Reactome:REACT_112874 "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1], Arabidopsis thaliana"
xref: Reactome:REACT_112935 "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1], Arabidopsis thaliana"
xref: Reactome:REACT_113015 "(d)AMP or (d)CMP + ATP <=> (d)ADP or (d)CDP + ADP [AK5], Escherichia coli"
xref: Reactome:REACT_113048 "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1], Drosophila melanogaster"
xref: Reactome:REACT_113383 "(d)AMP or (d)CMP + ATP <=> (d)ADP or (d)CDP + ADP [AK5], Caenorhabditis elegans"
xref: Reactome:REACT_113689 "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2], Arabidopsis thaliana"
xref: Reactome:REACT_113816 "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP [AK5], Escherichia coli"
xref: Reactome:REACT_114509 "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2], Oryza sativa"
xref: Reactome:REACT_114837 "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP [AK5], Xenopus tropicalis"
xref: Reactome:REACT_114962 "(d)AMP or (d)CMP + ATP <=> (d)ADP or (d)CDP + ADP [AK5], Xenopus tropicalis"
xref: Reactome:REACT_115045 "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1], Oryza sativa"
xref: Reactome:REACT_1332 "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP [DCK], Homo sapiens"
xref: Reactome:REACT_1547 "(2'-deoxy)cytidine + ATP => (d)CMP + ADP [DCK], Homo sapiens"
xref: Reactome:REACT_1691 "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2], Homo sapiens"
xref: Reactome:REACT_1716 "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP [AK5], Homo sapiens"
xref: Reactome:REACT_2062 "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1], Homo sapiens"
xref: Reactome:REACT_2162 "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2], Homo sapiens"
xref: Reactome:REACT_2223 "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP [DGUOK], Homo sapiens"
xref: Reactome:REACT_271 "(d)AMP or (d)CMP + ATP <=> (d)ADP or (d)CDP + ADP [AK5], Homo sapiens"
xref: Reactome:REACT_28613 "(2'-deoxy)cytidine + ATP => (d)CMP + ADP [DCK], Canis familiaris"
xref: Reactome:REACT_28763 "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2], Xenopus tropicalis"
xref: Reactome:REACT_28784 "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2], Gallus gallus"
xref: Reactome:REACT_29420 "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP [DCK], Taeniopygia guttata"
xref: Reactome:REACT_29729 "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1], Caenorhabditis elegans"
xref: Reactome:REACT_30492 "(d)AMP or (d)CMP + ATP <=> (d)ADP or (d)CDP + ADP [AK5], Canis familiaris"
xref: Reactome:REACT_32040 "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1], Oryza sativa"
xref: Reactome:REACT_32884 "(d)AMP or (d)CMP + ATP <=> (d)ADP or (d)CDP + ADP [AK5], Mus musculus"
xref: Reactome:REACT_33934 "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP [DCK], Danio rerio"
xref: Reactome:REACT_33950 "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1], Xenopus tropicalis"
xref: Reactome:REACT_34033 "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP [DCK], Rattus norvegicus"
xref: Reactome:REACT_437 "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1], Homo sapiens"
xref: Reactome:REACT_76970 "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1], Danio rerio"
xref: Reactome:REACT_77209 "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP [DGUOK], Mus musculus"
xref: Reactome:REACT_77432 "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP [DCK], Oryza sativa"
xref: Reactome:REACT_77833 "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP [DCK], Canis familiaris"
xref: Reactome:REACT_77865 "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP [DGUOK], Bos taurus"
xref: Reactome:REACT_78953 "(2'-deoxy)cytidine + ATP => (d)CMP + ADP [DCK], Oryza sativa"
xref: Reactome:REACT_79203 "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP [DGUOK], Gallus gallus"
xref: Reactome:REACT_80728 "(2'-deoxy)cytidine + ATP => (d)CMP + ADP [DCK], Arabidopsis thaliana"
xref: Reactome:REACT_80872 "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1], Taeniopygia guttata"
xref: Reactome:REACT_81123 "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1], Gallus gallus"
xref: Reactome:REACT_82180 "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2], Drosophila melanogaster"
xref: Reactome:REACT_82221 "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP [DGUOK], Oryza sativa"
xref: Reactome:REACT_82394 "(2'-deoxy)cytidine + ATP => (d)CMP + ADP [DCK], Taeniopygia guttata"
xref: Reactome:REACT_82702 "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1], Taeniopygia guttata"
xref: Reactome:REACT_83272 "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP [AK5], Danio rerio"
xref: Reactome:REACT_84083 "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1], Gallus gallus"
xref: Reactome:REACT_84539 "(2'-deoxy)cytidine + ATP => (d)CMP + ADP [DCK], Danio rerio"
xref: Reactome:REACT_86547 "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP [DCK], Gallus gallus"
xref: Reactome:REACT_87320 "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1], Bos taurus"
xref: Reactome:REACT_87676 "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1], Rattus norvegicus"
xref: Reactome:REACT_88272 "(d)AMP or (d)CMP + ATP <=> (d)ADP or (d)CDP + ADP [AK5], Danio rerio"
xref: Reactome:REACT_88679 "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP [AK5], Canis familiaris"
xref: Reactome:REACT_88724 "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2], Mus musculus"
xref: Reactome:REACT_88733 "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2], Canis familiaris"
xref: Reactome:REACT_89347 "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP [DGUOK], Xenopus tropicalis"
xref: Reactome:REACT_90833 "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP [DGUOK], Arabidopsis thaliana"
xref: Reactome:REACT_91025 "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP [DCK], Sus scrofa"
xref: Reactome:REACT_91618 "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2], Mus musculus"
xref: Reactome:REACT_91645 "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2], Rattus norvegicus"
xref: Reactome:REACT_91846 "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2], Taeniopygia guttata"
xref: Reactome:REACT_92245 "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1], Staphylococcus aureus N315"
xref: Reactome:REACT_93122 "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP [AK5], Gallus gallus"
xref: Reactome:REACT_93240 "(2'-deoxy)cytidine + ATP => (d)CMP + ADP [DCK], Gallus gallus"
xref: Reactome:REACT_93276 "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP [DGUOK], Rattus norvegicus"
xref: Reactome:REACT_94215 "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1], Sus scrofa"
xref: Reactome:REACT_94895 "(d)AMP or (d)CMP + ATP <=> (d)ADP or (d)CDP + ADP [AK5], Gallus gallus"
xref: Reactome:REACT_95080 "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP [AK5], Taeniopygia guttata"
xref: Reactome:REACT_96068 "(2'-deoxy)cytidine + ATP => (d)CMP + ADP [DCK], Rattus norvegicus"
xref: Reactome:REACT_96184 "(2'-deoxy)cytidine + ATP => (d)CMP + ADP [DCK], Bos taurus"
xref: Reactome:REACT_96581 "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2], Bos taurus"
xref: Reactome:REACT_98232 "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2], Bos taurus"
xref: Reactome:REACT_98307 "(2'-deoxy)cytidine + ATP => (d)CMP + ADP [DCK], Sus scrofa"
xref: Reactome:REACT_98539 "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP [DCK], Xenopus tropicalis"
xref: Reactome:REACT_98574 "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1], Xenopus tropicalis"
xref: Reactome:REACT_99601 "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP [DCK], Bos taurus"
xref: Reactome:REACT_99757 "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP [DCK], Mus musculus"
xref: Reactome:REACT_99959 "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP [DGUOK], Sus scrofa"
xref: Reactome:REACT_99976 "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2], Canis familiaris"
is_a: GO:0019205 ! nucleobase-containing compound kinase activity
relationship: part_of GO:0009165 ! nucleotide biosynthetic process

[Term]
id: GO:0019207
name: kinase regulator activity
namespace: molecular_function
def: "Modulates the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:ai]
subset: gosubset_prok
is_a: GO:0030234 ! enzyme regulator activity
relationship: has_part GO:0019900 ! kinase binding
relationship: part_of GO:0042325 ! regulation of phosphorylation
relationship: regulates GO:0016301 ! kinase activity

[Term]
id: GO:0019208
name: phosphatase regulator activity
namespace: molecular_function
def: "Modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule." [GOC:ai]
is_a: GO:0030234 ! enzyme regulator activity
relationship: has_part GO:0019902 ! phosphatase binding
relationship: regulates GO:0016791 ! phosphatase activity

[Term]
id: GO:0019209
name: kinase activator activity
namespace: molecular_function
def: "Binds to and increases the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008047 ! enzyme activator activity
is_a: GO:0019207 ! kinase regulator activity
relationship: part_of GO:0042327 ! positive regulation of phosphorylation
relationship: positively_regulates GO:0016301 ! kinase activity

[Term]
id: GO:0019210
name: kinase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:mah]
subset: gosubset_prok
is_a: GO:0004857 ! enzyme inhibitor activity
is_a: GO:0019207 ! kinase regulator activity
relationship: negatively_regulates GO:0016301 ! kinase activity
relationship: part_of GO:0042326 ! negative regulation of phosphorylation

[Term]
id: GO:0019211
name: phosphatase activator activity
namespace: molecular_function
def: "Increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule." [GOC:ai]
is_a: GO:0008047 ! enzyme activator activity
is_a: GO:0019208 ! phosphatase regulator activity
relationship: positively_regulates GO:0016791 ! phosphatase activity

[Term]
id: GO:0019212
name: phosphatase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule." [GOC:ai]
is_a: GO:0004857 ! enzyme inhibitor activity
is_a: GO:0019208 ! phosphatase regulator activity
relationship: negatively_regulates GO:0016791 ! phosphatase activity

[Term]
id: GO:0019213
name: deacetylase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule." [GOC:jl]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0019214
name: obsolete surfactant activity
namespace: molecular_function
def: "OBSOLETE. The action of reducing the surface tension of a liquid." [GOC:jl, ISBN:0198506732]
comment: This term was made obsolete because it represents involvement in a process.
synonym: "surfactant activity" EXACT []
is_obsolete: true
consider: GO:0050828

[Term]
id: GO:0019215
name: intermediate filament binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an intermediate filament, a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of higher eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space." [ISBN:0198506732]
is_a: GO:0032403 ! protein complex binding

[Term]
id: GO:0019216
name: regulation of lipid metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of lipid metabolism" EXACT []
is_a: GO:0080090 ! regulation of primary metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006629 ! lipid metabolic process
relationship: regulates GO:0006629 ! lipid metabolic process

[Term]
id: GO:0019217
name: regulation of fatty acid metabolic process
namespace: biological_process
alt_id: GO:0006632
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving fatty acids." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of fatty acid metabolism" EXACT []
is_a: GO:0010565 ! regulation of cellular ketone metabolic process
is_a: GO:0019216 ! regulation of lipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006631 ! fatty acid metabolic process
relationship: regulates GO:0006631 ! fatty acid metabolic process

[Term]
id: GO:0019218
name: regulation of steroid metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of steroid metabolism" EXACT []
is_a: GO:0019216 ! regulation of lipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008202 ! steroid metabolic process
relationship: regulates GO:0008202 ! steroid metabolic process

[Term]
id: GO:0019219
name: regulation of nucleobase-containing compound metabolic process
namespace: biological_process
def: "Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" RELATED [GOC:dph, GOC:tb]
synonym: "regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT []
is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
is_a: GO:0080090 ! regulation of primary metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006139 ! nucleobase-containing compound metabolic process
relationship: regulates GO:0006139 ! nucleobase-containing compound metabolic process

[Term]
id: GO:0019220
name: regulation of phosphate metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of phosphate metabolism" EXACT []
is_a: GO:0051174 ! regulation of phosphorus metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006796 ! phosphate-containing compound metabolic process
relationship: regulates GO:0006796 ! phosphate-containing compound metabolic process

[Term]
id: GO:0019221
name: cytokine-mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:19295629]
synonym: "cytokine and chemokine mediated signaling pathway" EXACT []
synonym: "cytokine mediated signalling pathway" EXACT []
xref: Reactome:REACT_25229 "Interferon Signaling, Homo sapiens"
is_a: GO:0007166 ! cell surface receptor signaling pathway
relationship: part_of GO:0071345 ! cellular response to cytokine stimulus

[Term]
id: GO:0019222
name: regulation of metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of metabolism" EXACT []
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008152 ! metabolic process
relationship: regulates GO:0008152 ! metabolic process

[Term]
id: GO:0019226
name: transmission of nerve impulse
namespace: biological_process
def: "The neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission." [GOC:curators, ISBN:0815316194]
synonym: "conduction of nerve impulse" EXACT [GOC:dph]
synonym: "signal transmission along a neuron" EXACT []
is_a: GO:0035637 ! multicellular organismal signaling
is_a: GO:0050877 ! neurological system process
relationship: has_part GO:0001508 ! action potential
relationship: has_part GO:0007268 ! synaptic transmission
relationship: part_of GO:0007154 ! cell communication

[Term]
id: GO:0019227
name: neuronal action potential propagation
namespace: biological_process
def: "The propagation of an action potential along an axon, away from the soma." [GOC:isa_complete]
is_a: GO:0050877 ! neurological system process
is_a: GO:0098870 ! action potential propagation
relationship: part_of GO:0019226 ! transmission of nerve impulse

[Term]
id: GO:0019228
name: neuronal action potential
namespace: biological_process
def: "An action potential that occurs in a neuron." [GOC:dph, GOC:isa_complete, GOC:tb]
synonym: "generation of action potential" RELATED [GOC:dph, GOC:tb]
is_a: GO:0001508 ! action potential
relationship: part_of GO:0019226 ! transmission of nerve impulse

[Term]
id: GO:0019229
name: regulation of vasoconstriction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels." [GOC:jl]
is_a: GO:0050880 ! regulation of blood vessel size
is_a: GO:1903522 ! regulation of blood circulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042310 ! vasoconstriction
relationship: regulates GO:0042310 ! vasoconstriction

[Term]
id: GO:0019230
name: proprioception
namespace: biological_process
def: "The series of events by which an organism senses the position, location, orientation, and movement of the body and its parts. Proprioception is mediated by proprioceptors, sensory nerve terminals found in muscles, tendons, and joint capsules, which give information concerning movements and position of the body. The receptors in the labyrinth are sometimes also considered proprioceptors." [http://www.onelook.com/, ISBN:072168677X]
xref: Wikipedia:Proprioception
is_a: GO:0007600 ! sensory perception
relationship: part_of GO:0050884 ! neuromuscular process controlling posture

[Term]
id: GO:0019231
name: perception of static position
namespace: biological_process
def: "The perception of the orientation of different parts of the body with respect to one another." [ISBN:072168677X]
is_a: GO:0019230 ! proprioception

[Term]
id: GO:0019232
name: perception of rate of movement
namespace: biological_process
def: "The series of events by which an organism senses the speed and direction of movement of the body and its parts." [GOC:mah]
synonym: "kinesthesia" EXACT []
is_a: GO:0019230 ! proprioception

[Term]
id: GO:0019233
name: sensory perception of pain
namespace: biological_process
def: "The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process." [http://www.onelook.com/]
synonym: "nociception" EXACT []
synonym: "perception of physiological pain" NARROW []
xref: Wikipedia:Nociception
is_a: GO:0007600 ! sensory perception

[Term]
id: GO:0019234
name: sensory perception of fast pain
namespace: biological_process
def: "The series of events required for an organism to receive a fast pain stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. Fast pain is often subjectively described as a sharp or stabbing pain; in humans, the signals from a fast pain stimulus are perceived and relayed along myelinated A-delta fibers to the central nervous system, reaching their target in about 0.1 seconds." [http://www.spine-health.com/]
is_a: GO:0019233 ! sensory perception of pain

[Term]
id: GO:0019235
name: sensory perception of slow pain
namespace: biological_process
def: "The series of events required for an organism to receive a slow pain stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. Slow pain is often subjectively described as an aching or throbbing pain; in humans, the signals from a slow pain stimulus are perceived and relayed along unmyelinated C fibers to the central nervous system, reaching their target in about 1 second. Slow pain is often associated with tissue destruction." [http://www.people.vcu.edu/~mikuleck/ssspain/, http://www.spine-health.com/]
is_a: GO:0019233 ! sensory perception of pain

[Term]
id: GO:0019236
name: response to pheromone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus." [GOC:jl]
subset: gosubset_prok
synonym: "pheromone response" EXACT []
is_a: GO:0010033 ! response to organic substance

[Term]
id: GO:0019237
name: centromeric DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a centromere, a region of chromosome where the spindle fibers attach during mitosis and meiosis." [GOC:jl, SO:0000577]
synonym: "centromere binding" EXACT []
is_a: GO:1990837 ! sequence-specific double-stranded DNA binding

[Term]
id: GO:0019238
name: cyclohydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2, in a reaction that involves the opening of a ring." [GOC:mah]
subset: gosubset_prok
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines

[Term]
id: GO:0019239
name: deaminase activity
namespace: molecular_function
def: "Catalysis of the removal of an amino group from a substrate, producing ammonia (NH3)." [GOC:jl]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0019240
name: citrulline biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins." [ISBN:0198506732]
subset: gosubset_prok
synonym: "citrulline anabolism" EXACT []
synonym: "citrulline biosynthesis" EXACT []
synonym: "citrulline formation" EXACT []
synonym: "citrulline synthesis" EXACT []
xref: MetaCyc:CITRULBIO-PWY
is_a: GO:0000052 ! citrulline metabolic process
is_a: GO:0042398 ! cellular modified amino acid biosynthetic process
is_a: GO:1901607 ! alpha-amino acid biosynthetic process

[Term]
id: GO:0019241
name: citrulline catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins." [ISBN:0198506732]
subset: gosubset_prok
synonym: "citrulline breakdown" EXACT []
synonym: "citrulline catabolism" EXACT []
synonym: "citrulline degradation" EXACT []
xref: MetaCyc:CITRULLINE-DEG-PWY
is_a: GO:0000052 ! citrulline metabolic process
is_a: GO:0042219 ! cellular modified amino acid catabolic process
is_a: GO:0044270 ! cellular nitrogen compound catabolic process
is_a: GO:1901606 ! alpha-amino acid catabolic process

[Term]
id: GO:0019242
name: methylglyoxal biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid." [GOC:ai]
subset: gosubset_prok
synonym: "methylglyoxal anabolism" EXACT []
synonym: "methylglyoxal biosynthesis" EXACT []
synonym: "methylglyoxal formation" EXACT []
synonym: "methylglyoxal synthesis" EXACT []
is_a: GO:0009438 ! methylglyoxal metabolic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0046184 ! aldehyde biosynthetic process

[Term]
id: GO:0019243
name: methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into D-lactate via the intermediate S-lactoyl-glutathione. Glutathione is used in the first step of the pathway and then regenerated in the second step." [GOC:ai, GOC:dph, PMID:2198020]
subset: gosubset_prok
synonym: "D-lactate biosynthesis from methylglyoxal" BROAD []
synonym: "D-lactate biosynthetic process from methylglyoxal" BROAD []
synonym: "glyoxalase system" RELATED []
synonym: "methylglyoxal breakdown to D-lactate" BROAD []
synonym: "methylglyoxal catabolism to D-lactate via S-lactoyl-glutathione" EXACT []
synonym: "methylglyoxal degradation to D-lactate" BROAD []
synonym: "methylglyoxal detoxification" RELATED []
xref: MetaCyc:PWY-5386
is_a: GO:0061727 ! methylglyoxal catabolic process to lactate

[Term]
id: GO:0019244
name: lactate biosynthetic process from pyruvate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lactate from other compounds, including pyruvate." [GOC:go_curators]
subset: gosubset_prok
synonym: "lactate anabolism from pyruvate" EXACT []
synonym: "lactate formation from pyruvate" EXACT []
synonym: "lactate synthesis from pyruvate" EXACT []
synonym: "pyruvate fermentation to lactate" EXACT []
xref: Reactome:R-HSA-71849.1
is_a: GO:0006090 ! pyruvate metabolic process
is_a: GO:0019249 ! lactate biosynthetic process
relationship: has_part GO:0004457 ! lactate dehydrogenase activity

[Term]
id: GO:0019245
name: D(-)-lactate biosynthetic process from pyruvate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of D(-)-lactate from other compounds, including pyruvate." [GOC:go_curators]
subset: gosubset_prok
synonym: "D(-)-lactate anabolism from pyruvate" EXACT []
synonym: "D(-)-lactate formation from pyruvate" EXACT []
synonym: "D(-)-lactate synthesis from pyruvate" EXACT []
is_a: GO:0019244 ! lactate biosynthetic process from pyruvate
relationship: has_part GO:0008720 ! D-lactate dehydrogenase activity

[Term]
id: GO:0019246
name: L(+)-lactate biosynthetic process from pyruvate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L(+)-lactate from other compounds, including pyruvate." [GOC:go_curators]
subset: gosubset_prok
synonym: "L(+)-lactate anabolism from pyruvate" EXACT []
synonym: "L(+)-lactate formation from pyruvate" EXACT []
synonym: "L(+)-lactate synthesis from pyruvate" EXACT []
synonym: "S-lactate biosynthetic process from pyruvate" EXACT []
xref: MetaCyc:PWY-5481
is_a: GO:0019244 ! lactate biosynthetic process from pyruvate
relationship: has_part GO:0004459 ! L-lactate dehydrogenase activity

[Term]
id: GO:0019247
name: lactate racemization
namespace: biological_process
def: "Partial conversion of one lactate enantiomer into another so that the specific optical rotation is decreased, or even reduced to zero, in the resulting mixture." [GOC:curators, PMID:16166538]
subset: gosubset_prok
is_a: GO:0006089 ! lactate metabolic process

[Term]
id: GO:0019248
name: D-lactate biosynthetic process from methylglyoxal via (R)-lactaldehyde
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of D-lactate from methylglyoxal, via the intermediate (R)-lactaldehyde." [GOC:dph, GOC:go_curators, MetaCyc:MGLDLCTANA-PWY]
subset: gosubset_prok
synonym: "D-lactate anabolism from methylglyoxal via (R)-lactaldehyde" EXACT []
synonym: "D-lactate formation from methylglyoxal via (R)-lactaldehyde" EXACT []
synonym: "D-lactate synthesis from methylglyoxal via (R)-lactaldehyde" EXACT []
xref: MetaCyc:MGLDLCTANA-PWY
is_a: GO:0019249 ! lactate biosynthetic process
is_a: GO:0061727 ! methylglyoxal catabolic process to lactate

[Term]
id: GO:0019249
name: lactate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lactate, the anion of lactic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "lactate anabolism" EXACT []
synonym: "lactate biosynthesis" EXACT []
synonym: "lactate formation" EXACT []
synonym: "lactate synthesis" EXACT []
is_a: GO:0006089 ! lactate metabolic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process

[Term]
id: GO:0019250
name: aerobic cobalamin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12) in the presence of oxygen." [GOC:go_curators]
subset: gosubset_prok
synonym: "aerobic cobalamin anabolism" EXACT []
synonym: "aerobic cobalamin biosynthesis" EXACT []
synonym: "aerobic cobalamin formation" EXACT []
synonym: "aerobic cobalamin synthesis" EXACT []
synonym: "aerobic vitamin B12 biosynthesis" EXACT []
synonym: "aerobic vitamin B12 biosynthetic process" EXACT []
synonym: "cobalamin biosynthesis, aerobic" EXACT []
synonym: "cobalamin biosynthetic process, aerobic" EXACT []
synonym: "vitamin B12 biosynthesis, aerobic" EXACT []
synonym: "vitamin B12 biosynthetic process, aerobic" EXACT []
xref: MetaCyc:P381-PWY
is_a: GO:0009236 ! cobalamin biosynthetic process

[Term]
id: GO:0019251
name: anaerobic cobalamin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12) in the absence of oxygen." [GOC:go_curators]
subset: gosubset_prok
synonym: "anaerobic cobalamin anabolism" EXACT []
synonym: "anaerobic cobalamin biosynthesis" EXACT []
synonym: "anaerobic cobalamin formation" EXACT []
synonym: "anaerobic cobalamin synthesis" EXACT []
synonym: "anaerobic vitamin B12 biosynthesis" EXACT []
synonym: "anaerobic vitamin B12 biosynthetic process" EXACT []
synonym: "cobalamin biosynthesis, anaerobic" EXACT []
synonym: "cobalamin biosynthetic process, anaerobic" EXACT []
synonym: "vitamin B12 biosynthesis, anaerobic" EXACT []
synonym: "vitamin B12 biosynthetic process, anaerobic" EXACT []
xref: MetaCyc:COBALSYN-PWY
is_a: GO:0009236 ! cobalamin biosynthetic process

[Term]
id: GO:0019252
name: starch biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of starch, the most important reserve polysaccharide in plants." [GOC:ai]
subset: gosubset_prok
synonym: "starch anabolism" EXACT []
synonym: "starch biosynthesis" EXACT []
synonym: "starch formation" EXACT []
synonym: "starch synthesis" EXACT []
xref: MetaCyc:PWY-622
is_a: GO:0005982 ! starch metabolic process
is_a: GO:0009250 ! glucan biosynthetic process

[Term]
id: GO:0019253
name: reductive pentose-phosphate cycle
namespace: biological_process
def: "The fixation of carbon dioxide (CO2) as glucose in the chloroplasts of C3 plants; uses ATP and NADPH formed in the light reactions of photosynthesis; carbon dioxide reacts with ribulose 1,5-bisphosphate (catalyzed by the function of ribulose-bisphosphate carboxylase) to yield two molecules of 3-phosphoglycerate; these are then phosphorylated by ATP to 1,3-bisphosphateglyceraldehyde which, in turn, is then reduced by NADPH to glyceraldehyde 3-phosphate. The glyceraldehyde 3-phosphate is converted to fructose 5-phosphate and ribulose 5-phosphate by aldolase and other enzymes; the ribulose 5-phosphate is phosphorylated by ATP to ribulose 1,5-bisphosphate." [ISBN:0198547684]
comment: See also the molecular function term 'ribulose-bisphosphate carboxylase activity ; GO:0016984'.
synonym: "C3 photosynthesis" NARROW []
synonym: "Calvin cycle" NARROW []
xref: MetaCyc:CALVIN-PWY
is_a: GO:0019685 ! photosynthesis, dark reaction
relationship: part_of GO:0015977 ! carbon fixation

[Term]
id: GO:0019254
name: carnitine metabolic process, CoA-linked
namespace: biological_process
def: "The chemical reactions and pathways involving carnitine, where metabolism is linked to CoA." [GOC:go_curators]
subset: gosubset_prok
synonym: "carnitine metabolism, CoA-linked" EXACT []
xref: MetaCyc:CARNMET-PWY
is_a: GO:0009437 ! carnitine metabolic process

[Term]
id: GO:0019255
name: glucose 1-phosphate metabolic process
namespace: biological_process
alt_id: GO:0006008
def: "The chemical reactions and pathways involving glucose 1-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-1." [GOC:ai]
subset: gosubset_prok
synonym: "glucose 1-phosphate metabolism" EXACT []
synonym: "glucose 1-phosphate utilization" RELATED [GOC:mah]
xref: MetaCyc:GLUCOSE1PMETAB-PWY
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:0019256
name: acrylonitrile catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of acrylonitrile, a colorless, volatile liquid with a pungent odor. Acrylonitrile is used in the production of acrylic fibers, plastics, and synthetic rubbers." [GOC:ai]
subset: gosubset_prok
synonym: "acrylonitrile breakdown" EXACT []
synonym: "acrylonitrile catabolism" EXACT []
synonym: "acrylonitrile degradation" EXACT []
xref: MetaCyc:P344-PWY
is_a: GO:0018865 ! acrylonitrile metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0050899 ! nitrile catabolic process

[Term]
id: GO:0019257
name: 4-nitrotoluene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 4-nitrotoluene, 1-methyl-4-nitrobenzene. It is a light yellow liquid with a weak aromatic odor." [GOC:ai]
subset: gosubset_prok
synonym: "4-nitrotoluene metabolism" EXACT []
synonym: "4NT metabolic process" EXACT []
synonym: "4NT metabolism" EXACT []
is_a: GO:0019326 ! nitrotoluene metabolic process

[Term]
id: GO:0019258
name: 4-nitrotoluene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 4-nitrotoluene, 1-methyl-4-nitrobenzene." [GOC:ai]
subset: gosubset_prok
synonym: "4-nitrotoluene breakdown" EXACT []
synonym: "4-nitrotoluene catabolism" EXACT []
synonym: "4-nitrotoluene degradation" EXACT []
synonym: "4NT catabolic process" EXACT []
synonym: "4NT catabolism" EXACT []
xref: MetaCyc:P421-PWY
is_a: GO:0019257 ! 4-nitrotoluene metabolic process
is_a: GO:0046263 ! nitrotoluene catabolic process

[Term]
id: GO:0019260
name: 1,2-dichloroethane catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 1,2-dichloroethane, a major commodity chemical used, for example, in the manufacture of vinyl chloride." [GOC:go_curators]
subset: gosubset_prok
synonym: "1,2-dichloroethane breakdown" EXACT []
synonym: "1,2-dichloroethane catabolism" EXACT []
synonym: "1,2-dichloroethane degradation" EXACT []
xref: MetaCyc:12DICHLORETHDEG-PWY
is_a: GO:0018899 ! 1,2-dichloroethane metabolic process
is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process

[Term]
id: GO:0019261
name: 1,4-dichlorobenzene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 1,4-dichlorobenzene (p-dichlorobenzene or paramoth), a derivative of benzene with two chlorine atoms attached at opposite positions on the ring." [GOC:ai]
subset: gosubset_prok
synonym: "1,4-dichlorobenzene breakdown" EXACT []
synonym: "1,4-dichlorobenzene catabolism" EXACT []
synonym: "1,4-dichlorobenzene degradation" EXACT []
xref: MetaCyc:14DICHLORBENZDEG-PWY
is_a: GO:0018912 ! 1,4-dichlorobenzene metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process

[Term]
id: GO:0019262
name: N-acetylneuraminate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of N-acetylneuraminate, the anion of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid." [ISBN:0198506732]
subset: gosubset_prok
synonym: "N-acetylneuraminate breakdown" EXACT []
synonym: "N-acetylneuraminate catabolism" EXACT []
synonym: "N-acetylneuraminate degradation" EXACT []
xref: MetaCyc:P441-PWY
is_a: GO:0006054 ! N-acetylneuraminate metabolic process
is_a: GO:0046348 ! amino sugar catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process

[Term]
id: GO:0019263
name: adamantanone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of adamantanone, tricyclo(3.3.1.13,7)decanone, a white crystalline solid used as an intermediate for microelectronics in the production of photoresists." [GOC:ai]
subset: gosubset_prok
synonym: "adamantanone breakdown" EXACT []
synonym: "adamantanone catabolism" EXACT []
synonym: "adamantanone degradation" EXACT []
xref: MetaCyc:P481-PWY
is_a: GO:0018866 ! adamantanone metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process

[Term]
id: GO:0019264
name: glycine biosynthetic process from serine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycine from other compounds, including serine." [GOC:go_curators]
subset: gosubset_prok
synonym: "glycine anabolism from serine" EXACT []
synonym: "glycine formation from serine" EXACT []
synonym: "glycine synthesis from serine" EXACT []
xref: MetaCyc:GLYSYN-PWY
is_a: GO:0006545 ! glycine biosynthetic process
is_a: GO:0006563 ! L-serine metabolic process

[Term]
id: GO:0019265
name: glycine biosynthetic process, by transamination of glyoxylate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycine by the transamination of glyoxylate." [GOC:go_curators]
subset: gosubset_prok
synonym: "glycine anabolism, by transamination of glyoxylate" EXACT []
synonym: "glycine formation, by transamination of glyoxylate" EXACT []
synonym: "glycine synthesis, by transamination of glyoxylate" EXACT []
is_a: GO:0006545 ! glycine biosynthetic process

[Term]
id: GO:0019266
name: asparagine biosynthetic process from oxaloacetate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of asparagine from other compounds, including oxaloacetate." [GOC:go_curators]
subset: gosubset_prok
synonym: "asparagine anabolism from oxaloacetate" EXACT []
synonym: "asparagine formation from oxaloacetate" EXACT []
synonym: "asparagine synthesis from oxaloacetate" EXACT []
xref: MetaCyc:ASPARAGINE-BIOSYNTHESIS
is_a: GO:0006107 ! oxaloacetate metabolic process
is_a: GO:0006529 ! asparagine biosynthetic process
is_a: GO:0043649 ! dicarboxylic acid catabolic process

[Term]
id: GO:0019267
name: asparagine biosynthetic process from cysteine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of asparagine from other compounds, including cysteine." [GOC:go_curators]
subset: gosubset_prok
synonym: "asparagine anabolism from cysteine" EXACT []
synonym: "asparagine formation from cysteine" EXACT []
synonym: "asparagine synthesis from cysteine" EXACT []
xref: MetaCyc:ASPSYNII-PWY
is_a: GO:0006529 ! asparagine biosynthetic process
is_a: GO:0006534 ! cysteine metabolic process

[Term]
id: GO:0019268
name: obsolete glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+)
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of glutamate, catalyzed by the enzyme glutamate dehydrogenase (NADP+)." [GOC:go_curators]
comment: This term was made obsolete because it represents a molecular function.
synonym: "glutamate anabolism, using glutamate dehydrogenase (NAD(P)+)" EXACT []
synonym: "glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+)" EXACT []
synonym: "glutamate formation, using glutamate dehydrogenase (NAD(P)+)" EXACT []
synonym: "glutamate synthesis, using glutamate dehydrogenase (NAD(P)+)" EXACT []
is_obsolete: true
consider: GO:0004353
consider: GO:0006537

[Term]
id: GO:0019269
name: obsolete glutamate biosynthetic process, using glutamate synthase (NADPH)
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of glutamate, catalyzed by the enzyme glutamate synthase (NADPH)." [GOC:go_curators]
comment: This term was made obsolete because it refers to a molecular function.
synonym: "glutamate anabolism, using glutamate synthase (NADPH)" EXACT []
synonym: "glutamate biosynthetic process, using glutamate synthase (NADPH)" EXACT []
synonym: "glutamate formation, using glutamate synthase (NADPH)" EXACT []
synonym: "glutamate synthesis, using glutamate synthase (NADPH)" EXACT []
is_obsolete: true
consider: GO:0004355
consider: GO:0006537

[Term]
id: GO:0019270
name: aerobactin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of aerobactin (C22H36N4O13), a hydroxamate iron transport compound. It is a conjugate of 6-(N-acetyl-N-hydroxylamine)-2-aminohexanoic acid and citric acid." [GOC:ai]
subset: gosubset_prok
synonym: "aerobactin anabolism" EXACT []
synonym: "aerobactin biosynthesis" EXACT []
synonym: "aerobactin formation" EXACT []
synonym: "aerobactin synthesis" EXACT []
xref: MetaCyc:AEROBACTINSYN-PWY
is_a: GO:0042398 ! cellular modified amino acid biosynthetic process
is_a: GO:0046442 ! aerobactin metabolic process
is_a: GO:0072351 ! tricarboxylic acid biosynthetic process

[Term]
id: GO:0019271
name: aerobactin transport
namespace: biological_process
def: "The directed movement of the hydroxamate iron transport compound aerobactin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Aerobactin (C22H36N4O13) is a conjugate of 6-(N-acetyl-N-hydroxylamine)-2-aminohexanoic acid and citric acid." [GOC:ai]
is_a: GO:0006842 ! tricarboxylic acid transport
is_a: GO:0072337 ! modified amino acid transport

[Term]
id: GO:0019272
name: L-alanine biosynthetic process from pyruvate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of alanine from other compounds, including pyruvate." [GOC:go_curators]
subset: gosubset_prok
synonym: "L-alanine anabolism from pyruvate" EXACT []
synonym: "L-alanine formation from pyruvate" EXACT []
synonym: "L-alanine synthesis from pyruvate" EXACT []
xref: MetaCyc:ALANINE-SYN2-PWY
xref: MetaCyc:ALANINE-VALINESYN-PWY
is_a: GO:0006090 ! pyruvate metabolic process
is_a: GO:0042852 ! L-alanine biosynthetic process

[Term]
id: GO:0019273
name: L-alanine biosynthetic process via ornithine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-alanine, via the intermediate ornithine." [GOC:go_curators]
subset: gosubset_prok
synonym: "L-alanine anabolism via ornithine" EXACT []
synonym: "L-alanine formation via ornithine" EXACT []
synonym: "L-alanine synthesis via ornithine" EXACT []
is_a: GO:0006591 ! ornithine metabolic process
is_a: GO:0042852 ! L-alanine biosynthetic process

[Term]
id: GO:0019276
name: UDP-N-acetylgalactosamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving UDP-N-acetylgalactosamine, a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "UDP-N-acetylgalactosamine metabolism" EXACT []
is_a: GO:0006040 ! amino sugar metabolic process
is_a: GO:0009225 ! nucleotide-sugar metabolic process

[Term]
id: GO:0019277
name: UDP-N-acetylgalactosamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of UDP-N-acetylgalactosamine, a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "UDP-N-acetylgalactosamine anabolism" EXACT []
synonym: "UDP-N-acetylgalactosamine biosynthesis" EXACT []
synonym: "UDP-N-acetylgalactosamine formation" EXACT []
synonym: "UDP-N-acetylgalactosamine synthesis" EXACT []
xref: MetaCyc:UDPNACETYLGALSYN-PWY
is_a: GO:0009226 ! nucleotide-sugar biosynthetic process
is_a: GO:0019276 ! UDP-N-acetylgalactosamine metabolic process
is_a: GO:0046349 ! amino sugar biosynthetic process

[Term]
id: GO:0019278
name: UDP-N-acetylgalactosamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of UDP-N-acetylgalactosamine, a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "UDP-N-acetylgalactosamine breakdown" EXACT []
synonym: "UDP-N-acetylgalactosamine catabolism" EXACT []
synonym: "UDP-N-acetylgalactosamine degradation" EXACT []
is_a: GO:0009227 ! nucleotide-sugar catabolic process
is_a: GO:0019276 ! UDP-N-acetylgalactosamine metabolic process
is_a: GO:0046348 ! amino sugar catabolic process

[Term]
id: GO:0019279
name: L-methionine biosynthetic process from L-homoserine via cystathionine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including L-homoserine, via the intermediate cystathionine." [GOC:go_curators]
subset: gosubset_prok
synonym: "L-methionine anabolism from L-homoserine via cystathionine" EXACT [GOC:mah]
synonym: "L-methionine formation from L-homoserine via cystathionine" EXACT [GOC:mah]
synonym: "L-methionine synthesis from L-homoserine via cystathionine" EXACT [GOC:mah]
synonym: "methionine biosynthetic process from L-homoserine via cystathionine" EXACT [GOC:mah]
xref: MetaCyc:HOMOSER-METSYN-PWY
is_a: GO:0009092 ! homoserine metabolic process
is_a: GO:0071266 ! 'de novo' L-methionine biosynthetic process

[Term]
id: GO:0019280
name: L-methionine biosynthetic process from homoserine via O-acetyl-L-homoserine and cystathionine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of methionine from other compounds, including homoserine, via the intermediates O-acetyl-L-homoserine and cystathionine." [GOC:go_curators]
subset: gosubset_prok
synonym: "L-methionine anabolism from homoserine via O-acetyl-L-homoserine and cystathionine" EXACT [GOC:mah]
synonym: "L-methionine formation from homoserine via O-acetyl-L-homoserine and cystathionine" EXACT [GOC:mah]
synonym: "L-methionine synthesis from homoserine via O-acetyl-L-homoserine and cystathionine" EXACT [GOC:mah]
synonym: "methionine biosynthetic process from homoserine via O-acetyl-L-homoserine and cystathionine" EXACT [GOC:mah]
xref: MetaCyc:HSERMETANA-PWY
is_a: GO:0019279 ! L-methionine biosynthetic process from L-homoserine via cystathionine

[Term]
id: GO:0019281
name: L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including homoserine, via the intermediates O-succinyl-L-homoserine and cystathionine." [GOC:go_curators]
subset: gosubset_prok
synonym: "L-methionine anabolism from homoserine via O-succinyl-L-homoserine and cystathionine" EXACT [GOC:mah]
synonym: "L-methionine formation from homoserine via O-succinyl-L-homoserine and cystathionine" EXACT [GOC:mah]
synonym: "L-methionine synthesis from homoserine via O-succinyl-L-homoserine and cystathionine" EXACT [GOC:mah]
synonym: "methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine" EXACT [GOC:mah]
xref: MetaCyc:MET-SAM-PWY
is_a: GO:0019279 ! L-methionine biosynthetic process from L-homoserine via cystathionine

[Term]
id: GO:0019283
name: L-methionine biosynthetic process from O-phospho-L-homoserine and cystathionine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including O-phospho-L-homoserine and cystathionine." [GOC:go_curators]
subset: gosubset_prok
synonym: "L-methionine anabolism from O-phospho-L-homoserine and cystathionine" EXACT [GOC:mah]
synonym: "L-methionine formation from O-phospho-L-homoserine and cystathionine" EXACT [GOC:mah]
synonym: "L-methionine synthesis from O-phospho-L-homoserine and cystathionine" EXACT [GOC:mah]
synonym: "methionine biosynthetic process from O-phospho-L-homoserine and cystathionine" EXACT [GOC:mah]
is_a: GO:0006575 ! cellular modified amino acid metabolic process
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:0071266 ! 'de novo' L-methionine biosynthetic process

[Term]
id: GO:0019284
name: L-methionine biosynthetic process from S-adenosylmethionine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including S-adenosylmethionine." [GOC:go_curators]
subset: gosubset_prok
synonym: "L-methionine anabolism from S-adenosylmethionine" EXACT [GOC:mah]
synonym: "L-methionine biosynthesis from S-adenosyl methionine" EXACT [GOC:mah]
synonym: "L-methionine biosynthetic process from S-adenosyl methionine" EXACT [GOC:mah]
synonym: "L-methionine formation from S-adenosylmethionine" EXACT [GOC:mah]
synonym: "L-methionine salvage from S-adenosylmethionine" EXACT []
synonym: "L-methionine synthesis from S-adenosylmethionine" EXACT [GOC:mah]
synonym: "methionine biosynthetic process from S-adenosylmethionine" EXACT [GOC:mah]
is_a: GO:0046500 ! S-adenosylmethionine metabolic process
is_a: GO:0071267 ! L-methionine salvage
relationship: part_of GO:0033353 ! S-adenosylmethionine cycle

[Term]
id: GO:0019285
name: glycine betaine biosynthetic process from choline
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of betaine (N-trimethylglycine) from the oxidation of choline." [GOC:jl]
subset: gosubset_prok
synonym: "choline oxidation" EXACT [GOC:dph, PMID:23563483]
synonym: "glycine betaine anabolism from choline" EXACT []
synonym: "glycine betaine formation from choline" EXACT []
synonym: "glycine betaine synthesis from choline" EXACT []
synonym: "N-trimethylglycine biosynthesis from choline" EXACT []
synonym: "N-trimethylglycine biosynthetic process from choline" EXACT []
xref: MetaCyc:BETSYN-PWY
xref: MetaCyc:CHOLINE-BETAINE-ANA-PWY
xref: MetaCyc:P542-PWY
is_a: GO:0019695 ! choline metabolic process
is_a: GO:0031456 ! glycine betaine biosynthetic process
is_a: GO:0044711 ! single-organism biosynthetic process

[Term]
id: GO:0019286
name: glycine betaine biosynthetic process from glycine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycine betaine from other compounds, including glycine." [GOC:go_curators]
subset: gosubset_prok
synonym: "glycine betaine anabolism from glycine" EXACT []
synonym: "glycine betaine formation from glycine" EXACT []
synonym: "glycine betaine synthesis from glycine" EXACT []
synonym: "N-trimethylglycine biosynthesis from glycine" EXACT []
synonym: "N-trimethylglycine biosynthetic process from glycine" EXACT []
xref: MetaCyc:P541-PWY
is_a: GO:0006544 ! glycine metabolic process
is_a: GO:0031456 ! glycine betaine biosynthetic process
is_a: GO:0044711 ! single-organism biosynthetic process

[Term]
id: GO:0019287
name: isopentenyl diphosphate biosynthetic process, mevalonate pathway
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, via the intermediate mevalonate. This pathway converts acetate, in the form of acetyl-CoA, to isopentenyl diphosphate (IPP), the fundamental unit in isoprenoid biosynthesis, through a series of mevalonate intermediates." [GOC:go_curators, MetaCyc:PWY-922]
subset: gosubset_prok
synonym: "Ac-MVA pathway" EXACT [PMID:14517367]
synonym: "acetate-mevalonate pathway" EXACT [PMID:14517367]
synonym: "isopentenyl diphosphate anabolism, mevalonate pathway" EXACT []
synonym: "isopentenyl diphosphate biosynthetic process via mevalonate" EXACT [GOC:pr]
synonym: "isopentenyl diphosphate formation, mevalonate pathway" EXACT []
synonym: "isopentenyl diphosphate synthesis, mevalonate pathway" EXACT []
is_a: GO:0006084 ! acetyl-CoA metabolic process
is_a: GO:0009240 ! isopentenyl diphosphate biosynthetic process

[Term]
id: GO:0019288
name: isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate-independent pathway. Isopentenyl diphosphate (IPP) is the fundamental unit in isoprenoid biosynthesis and is biosynthesized from pyruvate and glyceraldehyde 3-phosphate via intermediates, including 1-deoxy-D-xylulose 5-phosphate." [GOC:go_curators, MetaCyc:NONMEVIPP-PWY, PMID:18948055]
subset: gosubset_prok
synonym: "isopentenyl diphosphate anabolism, mevalonate-independent pathway" EXACT []
synonym: "isopentenyl diphosphate biosynthesis, mevalonate-independent" EXACT []
synonym: "isopentenyl diphosphate biosynthesis, non-mevalonate pathway" EXACT []
synonym: "isopentenyl diphosphate biosynthetic process via 1-deoxy-D-xylulose 5-phosphate" EXACT [GOC:pr]
synonym: "isopentenyl diphosphate biosynthetic process, MEP pathway" EXACT []
synonym: "isopentenyl diphosphate biosynthetic process, mevalonate-independent" EXACT []
synonym: "isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway" EXACT []
synonym: "isopentenyl diphosphate biosynthetic process, non-mevalonate pathway" EXACT []
synonym: "isopentenyl diphosphate formation, mevalonate-independent pathway" EXACT []
synonym: "isopentenyl diphosphate synthesis, mevalonate-independent pathway" EXACT []
synonym: "mevalonate-independent isopentenyl diphosphate biosynthesis" EXACT []
synonym: "mevalonate-independent isopentenyl diphosphate biosynthetic process" EXACT []
synonym: "non-MVA pathway" EXACT []
xref: MetaCyc:NONMEVIPP-PWY
is_a: GO:0006090 ! pyruvate metabolic process
is_a: GO:0009240 ! isopentenyl diphosphate biosynthetic process
is_a: GO:0019682 ! glyceraldehyde-3-phosphate metabolic process

[Term]
id: GO:0019289
name: rhizobactin 1021 biosynthetic process
namespace: biological_process
alt_id: GO:0031193
alt_id: GO:0031194
def: "The chemical reactions and pathways resulting in the formation of rhizobactin 1021, (E)-4-((3-(acetylhydroxyamino)propyl)-amino)-2-hydroxy-(2-(2-(3-(hydroxy(1-oxo-2-decenyl)amino)propyl)amino)-2-oxoethyl)-4-oxobutanoic acid, a siderophore produced by Sinorhizobium meliloti." [MetaCyc:PWY-761, PMID:11274118]
subset: gosubset_prok
synonym: "rhizobactin 1021 anabolism" EXACT []
synonym: "rhizobactin 1021 biosynthesis" EXACT []
synonym: "rhizobactin 1021 biosynthetic process, peptide formation" NARROW []
synonym: "rhizobactin 1021 biosynthetic process, peptide modification" NARROW []
synonym: "rhizobactin 1021 formation" EXACT []
synonym: "rhizobactin 1021 synthesis" EXACT []
xref: MetaCyc:PWY-761
is_a: GO:0019540 ! siderophore biosynthetic process from catechol
is_a: GO:0046494 ! rhizobactin 1021 metabolic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:1902645 ! tertiary alcohol biosynthetic process

[Term]
id: GO:0019290
name: siderophore biosynthetic process
namespace: biological_process
alt_id: GO:0031178
alt_id: GO:0031180
def: "The chemical reactions and pathways resulting in the formation of siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action." [GOC:go_curators]
comment: See also the biological process term 'nonribosomal peptide biosynthetic process ; GO:0019184'.
subset: gosubset_prok
synonym: "siderochrome biosynthesis" NARROW []
synonym: "siderochrome biosynthetic process" NARROW []
synonym: "siderophore anabolism" EXACT []
synonym: "siderophore biosynthesis" EXACT []
synonym: "siderophore biosynthetic process, peptide formation" NARROW []
synonym: "siderophore biosynthetic process, peptide modification" NARROW []
synonym: "siderophore formation" EXACT []
synonym: "siderophore synthesis" EXACT []
is_a: GO:0009237 ! siderophore metabolic process
is_a: GO:0019184 ! nonribosomal peptide biosynthetic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:0051188 ! cofactor biosynthetic process

[Term]
id: GO:0019292
name: tyrosine biosynthetic process from chorismate via 4-hydroxyphenylpyruvate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tyrosine from other compounds, including chorismate, via the intermediate 4-hydroxyphenylpyruvate." [GOC:go_curators]
subset: gosubset_prok
synonym: "tyrosine anabolism from chorismate via 4-hydroxyphenylpyruvate" EXACT []
synonym: "tyrosine biosynthetic process from chorismate via p-hydroxyphenylpyruvate" EXACT []
synonym: "tyrosine formation from chorismate via 4-hydroxyphenylpyruvate" EXACT []
synonym: "tyrosine synthesis from chorismate via 4-hydroxyphenylpyruvate" EXACT []
xref: MetaCyc:TYRSYN
is_a: GO:0006571 ! tyrosine biosynthetic process
is_a: GO:0046417 ! chorismate metabolic process

[Term]
id: GO:0019293
name: tyrosine biosynthetic process, by oxidation of phenylalanine
namespace: biological_process
alt_id: GO:0019291
def: "The chemical reactions and pathways resulting in the formation of tyrosine by the oxidation of phenylalanine." [GOC:go_curators]
subset: gosubset_prok
synonym: "tyrosine anabolism from chorismate via L-phenylalanine" EXACT []
synonym: "tyrosine anabolism, by oxidation of phenylalanine" EXACT []
synonym: "tyrosine biosynthetic process from chorismate via L-phenylalanine" EXACT []
synonym: "tyrosine formation from chorismate via L-phenylalanine" EXACT []
synonym: "tyrosine formation, by oxidation of phenylalanine" EXACT []
synonym: "tyrosine synthesis from chorismate via L-phenylalanine" EXACT []
synonym: "tyrosine synthesis, by oxidation of phenylalanine" EXACT []
is_a: GO:0006558 ! L-phenylalanine metabolic process
is_a: GO:0006571 ! tyrosine biosynthetic process
is_a: GO:0055114 ! oxidation-reduction process

[Term]
id: GO:0019294
name: keto-3-deoxy-D-manno-octulosonic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of keto-3-deoxy-D-manno-octulosonic acid, an acidic sugar present in lipopolysaccharides of the outer membranes of some Gram-negative bacteria." [CHEBI:32817, ISBN:0198506732]
subset: gosubset_prok
synonym: "KDO biosynthesis" EXACT []
synonym: "KDO biosynthetic process" EXACT []
synonym: "keto-3-deoxy-D-manno-octulosonic acid anabolism" EXACT []
synonym: "keto-3-deoxy-D-manno-octulosonic acid biosynthesis" EXACT []
synonym: "keto-3-deoxy-D-manno-octulosonic acid formation" EXACT []
synonym: "keto-3-deoxy-D-manno-octulosonic acid synthesis" EXACT []
synonym: "ketodeoxyoctanoate biosynthetic process" RELATED [ISBN:0198506732]
xref: MetaCyc:KDOSYN-PWY
is_a: GO:0046364 ! monosaccharide biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
is_a: GO:0046400 ! keto-3-deoxy-D-manno-octulosonic acid metabolic process
relationship: part_of GO:0009103 ! lipopolysaccharide biosynthetic process

[Term]
id: GO:0019295
name: coenzyme M biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of coenzyme M (2-thioethansulfonate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes." [ISBN:0198547684]
subset: gosubset_prok
synonym: "coenzyme M anabolism" EXACT []
synonym: "coenzyme M biosynthesis" EXACT []
synonym: "coenzyme M formation" EXACT []
synonym: "coenzyme M synthesis" EXACT []
xref: MetaCyc:P261-PWY
is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0019296 ! coenzyme M metabolic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:1901576 ! organic substance biosynthetic process

[Term]
id: GO:0019296
name: coenzyme M metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving coenzyme M (2-thioethansulfonate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes." [GOC:go_curators]
subset: gosubset_prok
synonym: "coenzyme M metabolism" EXACT []
is_a: GO:0006732 ! coenzyme metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0044710 ! single-organism metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0071704 ! organic substance metabolic process

[Term]
id: GO:0019297
name: coenzyme B metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving coenzyme B (7-mercaptoheptanoylthreonine phosphate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes." [GOC:go_curators]
subset: gosubset_prok
synonym: "coenzyme B metabolism" EXACT []
is_a: GO:0006575 ! cellular modified amino acid metabolic process
is_a: GO:0006732 ! coenzyme metabolic process
is_a: GO:0006793 ! phosphorus metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0019298
name: coenzyme B biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of coenzyme B (7-mercaptoheptanoylthreonine phosphate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes." [PMID:10940051]
subset: gosubset_prok
synonym: "coenzyme B anabolism" EXACT []
synonym: "coenzyme B biosynthesis" EXACT []
synonym: "coenzyme B formation" EXACT []
synonym: "coenzyme B synthesis" EXACT []
xref: MetaCyc:P241-PWY
is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0019297 ! coenzyme B metabolic process
is_a: GO:0042398 ! cellular modified amino acid biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process

[Term]
id: GO:0019299
name: rhamnose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving rhamnose, the hexose 6-deoxy-L-mannose. Rhamnose occurs commonly as a compound of plant glycosides, in polysaccharides of gums and mucilages, and in bacterial polysaccharides. It is also a component of some plant cell wall polysaccharides and frequently acts as the sugar components of flavonoids." [ISBN:0198506732]
subset: gosubset_prok
synonym: "rhamnose metabolism" EXACT []
is_a: GO:0019318 ! hexose metabolic process

[Term]
id: GO:0019300
name: rhamnose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of rhamnose, the hexose 6-deoxy-L-mannose." [ISBN:0198506732]
subset: gosubset_prok
synonym: "rhamnose anabolism" EXACT []
synonym: "rhamnose biosynthesis" EXACT []
synonym: "rhamnose formation" EXACT []
synonym: "rhamnose synthesis" EXACT []
is_a: GO:0019299 ! rhamnose metabolic process
is_a: GO:0019319 ! hexose biosynthetic process

[Term]
id: GO:0019301
name: rhamnose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of rhamnose, the hexose 6-deoxy-L-mannose." [ISBN:0198506732]
subset: gosubset_prok
synonym: "rhamnose breakdown" EXACT []
synonym: "rhamnose catabolism" EXACT []
synonym: "rhamnose degradation" EXACT []
xref: MetaCyc:RHAMCAT-PWY
is_a: GO:0019299 ! rhamnose metabolic process
is_a: GO:0019320 ! hexose catabolic process

[Term]
id: GO:0019302
name: D-ribose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of D-ribose, (ribo-pentose)." [ISBN:0198506732]
subset: gosubset_prok
synonym: "D-ribose anabolism" EXACT []
synonym: "D-ribose biosynthesis" EXACT []
synonym: "D-ribose formation" EXACT []
synonym: "D-ribose synthesis" EXACT []
is_a: GO:0006014 ! D-ribose metabolic process
is_a: GO:0019322 ! pentose biosynthetic process

[Term]
id: GO:0019303
name: D-ribose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-ribose (ribo-pentose)." [ISBN:0198506732]
subset: gosubset_prok
synonym: "D-ribose breakdown" EXACT []
synonym: "D-ribose catabolism" EXACT []
synonym: "D-ribose degradation" EXACT []
xref: MetaCyc:RIBOKIN-PWY
is_a: GO:0006014 ! D-ribose metabolic process
is_a: GO:0019323 ! pentose catabolic process

[Term]
id: GO:0019304
name: anaerobic rhamnose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of rhamnose, the hexose 6-deoxy-L-mannose, that occurs in the absence of oxygen." [GOC:ai]
subset: gosubset_prok
synonym: "anaerobic rhamnose breakdown" EXACT []
synonym: "anaerobic rhamnose catabolism" EXACT []
synonym: "anaerobic rhamnose degradation" EXACT []
is_a: GO:0019301 ! rhamnose catabolic process

[Term]
id: GO:0019305
name: dTDP-rhamnose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dTDP-rhamnose, a substance composed of rhamnose in glycosidic linkage with deoxyribosylthymine diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "dTDP-rhamnose anabolism" EXACT []
synonym: "dTDP-rhamnose biosynthesis" EXACT []
synonym: "dTDP-rhamnose formation" EXACT []
synonym: "dTDP-rhamnose synthesis" EXACT []
xref: MetaCyc:DTDPRHAMSYN-PWY
xref: MetaCyc:PWY-3221
is_a: GO:0009226 ! nucleotide-sugar biosynthetic process
is_a: GO:0046383 ! dTDP-rhamnose metabolic process

[Term]
id: GO:0019306
name: GDP-D-rhamnose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of GDP-D-rhamnose, a substance composed of rhamnose in glycosidic linkage with guanosine diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "GDP-D-rhamnose anabolism" EXACT []
synonym: "GDP-D-rhamnose biosynthesis" EXACT []
synonym: "GDP-D-rhamnose formation" EXACT []
synonym: "GDP-D-rhamnose synthesis" EXACT []
xref: MetaCyc:GDPRHAMSYN-PWY
is_a: GO:0009226 ! nucleotide-sugar biosynthetic process
is_a: GO:0046382 ! GDP-D-rhamnose metabolic process

[Term]
id: GO:0019307
name: mannose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of mannose, the aldohexose manno-hexose, the C-2 epimer of glucose." [GOC:ai]
subset: gosubset_prok
synonym: "mannose anabolism" EXACT []
synonym: "mannose biosynthesis" EXACT []
synonym: "mannose formation" EXACT []
synonym: "mannose synthesis" EXACT []
is_a: GO:0006013 ! mannose metabolic process
is_a: GO:0019319 ! hexose biosynthetic process

[Term]
id: GO:0019308
name: dTDP-mannose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dTDP-mannose, a substance composed of mannose in glycosidic linkage with deoxyribosylthymine diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "dTDP-mannose anabolism" EXACT []
synonym: "dTDP-mannose biosynthesis" EXACT []
synonym: "dTDP-mannose formation" EXACT []
synonym: "dTDP-mannose synthesis" EXACT []
is_a: GO:0009226 ! nucleotide-sugar biosynthetic process
is_a: GO:0046371 ! dTDP-mannose metabolic process

[Term]
id: GO:0019309
name: mannose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of mannose, the aldohexose manno-hexose, the C-2 epimer of glucose." [GOC:ai]
subset: gosubset_prok
synonym: "mannose breakdown" EXACT []
synonym: "mannose catabolism" EXACT []
synonym: "mannose degradation" EXACT []
xref: MetaCyc:MANNCAT-PWY
is_a: GO:0006013 ! mannose metabolic process
is_a: GO:0019320 ! hexose catabolic process

[Term]
id: GO:0019310
name: inositol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms." [CHEBI:24848, GOC:go_curators]
subset: gosubset_prok
synonym: "inositol breakdown" EXACT []
synonym: "inositol catabolism" EXACT []
synonym: "inositol degradation" EXACT []
synonym: "myo-inositol catabolic process" NARROW []
synonym: "myo-inositol catabolism" NARROW []
synonym: "vitamin Bh catabolic process" EXACT []
synonym: "vitamin Bh catabolism" EXACT []
xref: MetaCyc:P562-PWY
is_a: GO:0006020 ! inositol metabolic process
is_a: GO:0044275 ! cellular carbohydrate catabolic process
is_a: GO:0044724 ! single-organism carbohydrate catabolic process
is_a: GO:0046174 ! polyol catabolic process

[Term]
id: GO:0019311
name: sorbose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sorbose, the ketohexose xylo-2-hexulose. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid." [ISBN:0198506732]
subset: gosubset_prok
synonym: "sorbose metabolism" EXACT []
is_a: GO:0019318 ! hexose metabolic process

[Term]
id: GO:0019312
name: L-sorbose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sorbose, the L-enantiomer of the ketohexose xylo-2-hexulose. L-sorbose is formed by bacterial oxidation of sorbitol." [CHEBI:17266, GOC:jsg, GOC:mah, ISBN:0198506732]
subset: gosubset_prok
synonym: "L-sorbose metabolism" EXACT []
xref: MetaCyc:P302-PWY
is_a: GO:0019311 ! sorbose metabolic process

[Term]
id: GO:0019313
name: allose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving allose, allo-hexose, an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3." [ISBN:0198506732]
subset: gosubset_prok
synonym: "allose metabolism" EXACT []
is_a: GO:0019318 ! hexose metabolic process

[Term]
id: GO:0019314
name: D-allose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-allose, the D-enantiomer of allo-hexose, an aldohexose similar to glucose." [CHEBI:17393, GOC:ai, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "D-allose metabolism" EXACT []
is_a: GO:0019313 ! allose metabolic process

[Term]
id: GO:0019315
name: D-allose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of D-allose, the D-enantiomer of allo-hexose, an aldohexose similar to glucose." [CHEBI:17393, GOC:ai, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "D-allose anabolism" EXACT []
synonym: "D-allose biosynthesis" EXACT []
synonym: "D-allose formation" EXACT []
synonym: "D-allose synthesis" EXACT []
is_a: GO:0019314 ! D-allose metabolic process
is_a: GO:0046366 ! allose biosynthetic process

[Term]
id: GO:0019316
name: D-allose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-allose, the D-enantiomer of allo-hexose, an aldohexose similar to glucose." [CHEBI:17393, GOC:ai, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "D-allose breakdown" EXACT []
synonym: "D-allose catabolism" EXACT []
synonym: "D-allose degradation" EXACT []
xref: MetaCyc:PWY0-44
is_a: GO:0019314 ! D-allose metabolic process
is_a: GO:0046367 ! allose catabolic process

[Term]
id: GO:0019317
name: fucose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of fucose (6-deoxygalactose)." [GOC:jl]
subset: gosubset_prok
synonym: "fucose breakdown" EXACT []
synonym: "fucose catabolism" EXACT []
synonym: "fucose degradation" EXACT []
xref: MetaCyc:FUCCAT-PWY
is_a: GO:0006004 ! fucose metabolic process
is_a: GO:0019320 ! hexose catabolic process

[Term]
id: GO:0019318
name: hexose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732]
subset: gosubset_prok
synonym: "hexose metabolism" EXACT []
is_a: GO:0005996 ! monosaccharide metabolic process

[Term]
id: GO:0019319
name: hexose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732]
subset: gosubset_prok
synonym: "hexose anabolism" EXACT []
synonym: "hexose biosynthesis" EXACT []
synonym: "hexose formation" EXACT []
synonym: "hexose synthesis" EXACT []
is_a: GO:0019318 ! hexose metabolic process
is_a: GO:0046364 ! monosaccharide biosynthetic process

[Term]
id: GO:0019320
name: hexose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732]
subset: gosubset_prok
synonym: "hexose breakdown" EXACT []
synonym: "hexose catabolism" EXACT []
synonym: "hexose degradation" EXACT []
is_a: GO:0019318 ! hexose metabolic process
is_a: GO:0046365 ! monosaccharide catabolic process

[Term]
id: GO:0019321
name: pentose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a pentose, any monosaccharide with a chain of five carbon atoms in the molecule." [ISBN:0198506732]
subset: gosubset_prok
synonym: "pentose metabolism" EXACT []
is_a: GO:0005996 ! monosaccharide metabolic process

[Term]
id: GO:0019322
name: pentose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a pentose, any monosaccharide with a chain of five carbon atoms in the molecule." [ISBN:0198506732]
subset: gosubset_prok
synonym: "pentose anabolism" EXACT []
synonym: "pentose biosynthesis" EXACT []
synonym: "pentose formation" EXACT []
synonym: "pentose synthesis" EXACT []
is_a: GO:0019321 ! pentose metabolic process
is_a: GO:0046364 ! monosaccharide biosynthetic process

[Term]
id: GO:0019323
name: pentose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a pentose, any monosaccharide with a chain of five carbon atoms in the molecule." [ISBN:0198506732]
subset: gosubset_prok
synonym: "pentose breakdown" EXACT []
synonym: "pentose catabolism" EXACT []
synonym: "pentose degradation" EXACT []
is_a: GO:0019321 ! pentose metabolic process
is_a: GO:0046365 ! monosaccharide catabolic process

[Term]
id: GO:0019324
name: L-lyxose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving L-lyxose, the L-enantiomer of aldopentose lyxo-pentose, the C-2 epimer of xylose." [GOC:jsg, GOC:mah, ISBN:0198506732]
subset: gosubset_prok
synonym: "L-lyxose metabolism" EXACT []
xref: MetaCyc:LYXMET-PWY
is_a: GO:0019321 ! pentose metabolic process

[Term]
id: GO:0019325
name: anaerobic fructose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of fructose that occurs in the absence of oxygen." [GOC:ai]
subset: gosubset_prok
synonym: "anaerobic fructose breakdown" EXACT []
synonym: "anaerobic fructose catabolism" EXACT []
synonym: "anaerobic fructose degradation" EXACT []
xref: MetaCyc:ANAEROFRUCAT-PWY
is_a: GO:0006001 ! fructose catabolic process
is_a: GO:0019317 ! fucose catabolic process

[Term]
id: GO:0019326
name: nitrotoluene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nitrotoluene, any methylbenzene molecule with NO2 group(s) attached." [GOC:ai]
subset: gosubset_prok
synonym: "nitrotoluene metabolism" EXACT []
is_a: GO:0006807 ! nitrogen compound metabolic process
is_a: GO:0072490 ! toluene-containing compound metabolic process

[Term]
id: GO:0019327
name: lead sulfide oxidation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the conversion of lead sulfide to lead sulfate." [MetaCyc:P301-PWY]
subset: gosubset_prok
synonym: "lead sulphide oxidation" EXACT [GOC:mah]
synonym: "oxidation of galena" EXACT []
synonym: "oxidation of lead sulfide" EXACT [GOC:curators]
xref: MetaCyc:P301-PWY
is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds

[Term]
id: GO:0019328
name: anaerobic gallate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid, in the absence of oxygen." [GOC:jl]
subset: gosubset_prok
synonym: "anaerobic gallate breakdown" EXACT []
synonym: "anaerobic gallate catabolism" EXACT []
synonym: "anaerobic gallate degradation" EXACT []
synonym: "anaerobic gallic acid catabolic process" EXACT []
synonym: "anaerobic gallic acid catabolism" EXACT []
synonym: "gallate fermentation" EXACT []
xref: MetaCyc:P3-PWY
is_a: GO:0019396 ! gallate catabolic process

[Term]
id: GO:0019329
name: ammonia oxidation
namespace: biological_process
def: "The chemical reactions and pathways by which ammonia or ammonium is converted to molecular nitrogen or another nitrogen compound, with accompanying loss of electrons." [GOC:mah, MetaCyc:AMMOXID-PWY, MetaCyc:P303-PWY, MetaCyc:PWY-2242]
subset: gosubset_prok
is_a: GO:0006807 ! nitrogen compound metabolic process
is_a: GO:0044281 ! small molecule metabolic process
is_a: GO:0055114 ! oxidation-reduction process

[Term]
id: GO:0019330
name: aldoxime metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aldoximes, compounds derived by the reaction of an aldose with hydroxylamine, thus containing the aldoxime group -HC=NOH." [CHEBI:22307, GOC:curators]
synonym: "aldoxime metabolism" EXACT []
xref: MetaCyc:P345-PWY
is_a: GO:0006807 ! nitrogen compound metabolic process
is_a: GO:0071704 ! organic substance metabolic process

[Term]
id: GO:0019331
name: anaerobic respiration, using ammonium as electron donor
namespace: biological_process
def: "The oxidation of ammonium (NH4) to nitrogen (N2) in the absence of oxygen, using nitrite (NO2) as the electron acceptor. It is suggested that hydroxylamine and ammonium are combined to yield hydrazine, which is subsequently oxidized to N2." [MetaCyc:P303-PWY]
subset: gosubset_prok
synonym: "anaerobic ammonium oxidation" BROAD []
synonym: "anammox" EXACT []
xref: MetaCyc:P303-PWY
xref: Wikipedia:Anammox
is_a: GO:0009061 ! anaerobic respiration
is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds
is_a: GO:0019329 ! ammonia oxidation
is_a: GO:0034641 ! cellular nitrogen compound metabolic process

[Term]
id: GO:0019332
name: aerobic respiration, using nitrite as electron donor
namespace: biological_process
def: "The oxidation of nitrite (NO2) to nitrate (NO3), using oxygen (O2) as the electron acceptor. Nitrite oxidation is the final step in nitrification, the oxidation of ammonia to nitrate, and nitrite oxidoreductase (NOR) is the key enzyme complex that catalyzes the conversion of nitrite to nitrate in nitrite oxidizing species." [MetaCyc:P282-PWY]
subset: gosubset_prok
synonym: "nitrite oxidation" BROAD []
xref: MetaCyc:P282-PWY
is_a: GO:0009060 ! aerobic respiration
is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds
is_a: GO:0034641 ! cellular nitrogen compound metabolic process

[Term]
id: GO:0019333
name: denitrification pathway
namespace: biological_process
def: "The reduction of nitrate to dinitrogen by four reactions; each intermediate is transformed to the next lower oxidation state; also part of cellular bioenergetics; the nitrogen compounds can serve as terminal acceptors for electron transport phosphorylation in place of oxygen." [MetaCyc:DENITRIFICATION-PWY]
xref: MetaCyc:DENITRIFICATION-PWY
is_a: GO:0071941 ! nitrogen cycle metabolic process

[Term]
id: GO:0019334
name: p-cymene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of p-cymene, 1-methyl-4-isopropylbenzene, one of the alkyl-substituted aromatic hydrocarbons found in volatile oils from over 100 plants." [GOC:ai]
subset: gosubset_prok
synonym: "p-cymene breakdown" EXACT []
synonym: "p-cymene catabolism" EXACT []
synonym: "p-cymene degradation" EXACT []
xref: MetaCyc:PWY-741
is_a: GO:0018953 ! p-cymene metabolic process
is_a: GO:0043694 ! monoterpene catabolic process
is_a: GO:0072491 ! toluene-containing compound catabolic process

[Term]
id: GO:0019335
name: 3-methylquinoline catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 3-methylquinoline, C10H9N, an aromatic compound composed of a benzene ring and a heterocyclic N-containing ring." [GOC:ai]
subset: gosubset_prok
synonym: "3-methylquinoline breakdown" EXACT []
synonym: "3-methylquinoline catabolism" EXACT []
synonym: "3-methylquinoline degradation" EXACT []
xref: MetaCyc:PWY-721
is_a: GO:0018930 ! 3-methylquinoline metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process

[Term]
id: GO:0019336
name: phenol-containing compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring." [CHEBI:33853, GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "phenol-containing compound breakdown" EXACT [GOC:curators]
synonym: "phenol-containing compound catabolism" EXACT [GOC:curators]
synonym: "phenol-containing compound degradation" EXACT [GOC:curators]
xref: MetaCyc:PHENOLDEG-PWY
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901616 ! organic hydroxy compound catabolic process

[Term]
id: GO:0019337
name: tetrachloroethylene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tetrachloroethylene, a derivative of ethene with the hydrogen atoms replaced by chlorines." [GOC:ai]
subset: gosubset_prok
synonym: "tetrachloroethene catabolic process" EXACT []
synonym: "tetrachloroethene catabolism" EXACT []
synonym: "tetrachloroethylene breakdown" EXACT []
synonym: "tetrachloroethylene catabolism" EXACT []
synonym: "tetrachloroethylene degradation" EXACT []
xref: MetaCyc:PCEDEG-PWY
is_a: GO:0018967 ! tetrachloroethylene metabolic process
is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process

[Term]
id: GO:0019338
name: pentachlorophenol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pentachlorophenol, a chlorinated insecticide and fungicide used primarily to protect timber from fungal rot and wood boring insects. Pentachlorophenol is significantly toxic to mammals, plants, and many microorganisms." [GOC:go_curators]
subset: gosubset_prok
synonym: "pentachlorophenol breakdown" EXACT []
synonym: "pentachlorophenol catabolism" EXACT []
synonym: "pentachlorophenol degradation" EXACT []
xref: MetaCyc:PCPDEG-PWY
is_a: GO:0018961 ! pentachlorophenol metabolic process
is_a: GO:0019336 ! phenol-containing compound catabolic process

[Term]
id: GO:0019339
name: parathion catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of parathion, a highly toxic organophosphate compound. Degradation of parathion by sunlight or liver enzymes can result in the formation of the active compound paraoxon which interferes with the nervous system through cholinesterase inhibition." [UM-BBD_pathwayID:pthn]
subset: gosubset_prok
synonym: "parathion breakdown" EXACT []
synonym: "parathion catabolism" EXACT []
synonym: "parathion degradation" EXACT []
xref: MetaCyc:PARATHION-DEGRADATION-PWY
is_a: GO:0018952 ! parathion metabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0046434 ! organophosphate catabolic process

[Term]
id: GO:0019340
name: dibenzofuran catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dibenzofuran, a substance composed of two benzene rings linked by one ether bond and one carbon-carbon bond." [GOC:ai]
subset: gosubset_prok
synonym: "dibenzofuran breakdown" EXACT []
synonym: "dibenzofuran catabolism" EXACT []
synonym: "dibenzofuran degradation" EXACT []
xref: MetaCyc:P662-PWY
is_a: GO:0018893 ! dibenzofuran metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0044712 ! single-organism catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process

[Term]
id: GO:0019341
name: dibenzo-p-dioxin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dibenzo-p-dioxin, a substance composed of two benzene rings linked by two ether bonds." [GOC:ai]
subset: gosubset_prok
synonym: "dibenzo-p-dioxin breakdown" EXACT []
synonym: "dibenzo-p-dioxin catabolism" EXACT []
synonym: "dibenzo-p-dioxin degradation" EXACT []
xref: MetaCyc:P661-PWY
is_a: GO:0018894 ! dibenzo-p-dioxin metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0044282 ! small molecule catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process

[Term]
id: GO:0019342
name: trypanothione biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of trypanothione (N1,N6,-bis(glutathionyl)spermidine) in two steps from glutathione and spermidine via an N1- or N8-glutathionylspermidine intermediate. Trypanothione appears to be an essential redox intermediate in intracellular thiol redox regulation. It also plays a role in protecting against oxidative stress." [MetaCyc:TRYPANOSYN-PWY, PMID:9677355]
subset: gosubset_prok
synonym: "trypanothione anabolism" EXACT []
synonym: "trypanothione biosynthesis" EXACT []
synonym: "trypanothione formation" EXACT []
synonym: "trypanothione synthesis" EXACT []
xref: MetaCyc:TRYPANOSYN-PWY
is_a: GO:0046206 ! trypanothione metabolic process
is_a: GO:1901687 ! glutathione derivative biosynthetic process

[Term]
id: GO:0019343
name: cysteine biosynthetic process via cystathionine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cysteine, via the intermediate cystathionine." [GOC:go_curators]
subset: gosubset_prok
synonym: "cysteine anabolism via cystathionine" EXACT []
synonym: "cysteine formation via cystathionine" EXACT []
synonym: "cysteine synthesis via cystathionine" EXACT []
is_a: GO:0019344 ! cysteine biosynthetic process

[Term]
id: GO:0019344
name: cysteine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "cysteine anabolism" EXACT []
synonym: "cysteine biosynthesis" EXACT []
synonym: "cysteine formation" EXACT []
synonym: "cysteine synthesis" EXACT []
is_a: GO:0000097 ! sulfur amino acid biosynthetic process
is_a: GO:0006534 ! cysteine metabolic process
is_a: GO:0009070 ! serine family amino acid biosynthetic process

[Term]
id: GO:0019345
name: cysteine biosynthetic process via S-sulfo-L-cysteine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cysteine, via the intermediate S-sulfo-L-cysteine." [GOC:go_curators]
subset: gosubset_prok
synonym: "cysteine anabolism via S-sulfo-L-cysteine" EXACT []
synonym: "cysteine biosynthesis via S-sulpho-L-cysteine" EXACT []
synonym: "cysteine biosynthetic process via S-sulpho-L-cysteine" EXACT []
synonym: "cysteine formation via S-sulfo-L-cysteine" EXACT []
synonym: "cysteine synthesis via S-sulfo-L-cysteine" EXACT []
is_a: GO:0019344 ! cysteine biosynthetic process

[Term]
id: GO:0019346
name: transsulfuration
namespace: biological_process
def: "The interconversion of homocysteine and cysteine via cystathionine. In contrast with enteric bacteria and mammals, Saccharomyces cerevisiae has two transsulfuration pathways employing two separate sets of enzymes." [MetaCyc:PWY-801]
subset: gosubset_prok
synonym: "homocysteine-cysteine interconversion" NARROW []
synonym: "transsulphuration" EXACT []
xref: MetaCyc:PWY-801
xref: Reactome:REACT_115589 "Cysteine formation from homocysteine, Homo sapiens"
xref: Wikipedia:Transsulfuration_pathway
is_a: GO:0006534 ! cysteine metabolic process
is_a: GO:0009092 ! homoserine metabolic process
is_a: GO:0050667 ! homocysteine metabolic process

[Term]
id: GO:0019347
name: GDP-alpha-D-mannosylchitobiosyldiphosphodolichol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of GDP-alpha-D-mannosylchitobiosyldiphosphodolichol, a substance composed of mannosylchitobiosyldiphosphodolichol in glycosidic linkage with guanosine diphosphate." [GOC:ai]
synonym: "GDP-alpha-D-mannosylchitobiosyldiphosphodolichol anabolism" EXACT []
synonym: "GDP-alpha-D-mannosylchitobiosyldiphosphodolichol biosynthesis" EXACT []
synonym: "GDP-alpha-D-mannosylchitobiosyldiphosphodolichol formation" EXACT []
synonym: "GDP-alpha-D-mannosylchitobiosyldiphosphodolichol synthesis" EXACT []
xref: MetaCyc:MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS
is_a: GO:0008654 ! phospholipid biosynthetic process
is_a: GO:0009165 ! nucleotide biosynthetic process
is_a: GO:0009247 ! glycolipid biosynthetic process
is_a: GO:0016114 ! terpenoid biosynthetic process
is_a: GO:0046376 ! GDP-alpha-D-mannosylchitobiosyldiphosphodolichol metabolic process

[Term]
id: GO:0019348
name: dolichol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dolichols, any 2,3-dihydropolyprenol derived from four or more linked isoprene units." [ISBN:0198506732]
synonym: "dolichol metabolism" EXACT []
is_a: GO:0016093 ! polyprenol metabolic process

[Term]
id: GO:0019349
name: ribitol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ribitol, a pentitol derived formally by reduction of the -CHO group of either D- or L-ribose. It occurs free in some plants and is a component of riboflavin." [ISBN:0198506732]
subset: gosubset_prok
synonym: "ribitol metabolism" EXACT []
is_a: GO:0019519 ! pentitol metabolic process

[Term]
id: GO:0019350
name: teichoic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of teichoic acid, any polymer occurring in the cell wall, membrane or capsule of Gram-positive bacteria and containing chains of glycerol phosphate or ribitol phosphate residues." [ISBN:0198506732]
subset: gosubset_prok
synonym: "teichoic acid anabolism" EXACT []
synonym: "teichoic acid biosynthesis" EXACT []
synonym: "teichoic acid formation" EXACT []
synonym: "teichoic acid synthesis" EXACT []
xref: MetaCyc:TEICHOICACID-PWY
is_a: GO:0016053 ! organic acid biosynthetic process
is_a: GO:0044038 ! cell wall macromolecule biosynthetic process
is_a: GO:0046374 ! teichoic acid metabolic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process
relationship: part_of GO:0009273 ! peptidoglycan-based cell wall biogenesis

[Term]
id: GO:0019351
name: dethiobiotin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dethiobiotin, a derivative of biotin in which the sulfur atom has been replaced by two hydrogen atoms." [GOC:ai, ISBN:0198506732]
subset: gosubset_prok
synonym: "desthiobiotin biosynthesis" EXACT []
synonym: "desthiobiotin biosynthetic process" EXACT []
synonym: "dethiobiotin anabolism" EXACT []
synonym: "dethiobiotin biosynthesis" EXACT []
synonym: "dethiobiotin formation" EXACT []
synonym: "dethiobiotin synthesis" EXACT []
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process
is_a: GO:0046450 ! dethiobiotin metabolic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process

[Term]
id: GO:0019352
name: protoporphyrinogen IX biosynthetic process from glycine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX from other compounds, including glycine." [GOC:go_curators]
subset: gosubset_prok
synonym: "protoporphyrinogen IX anabolism from glycine" EXACT []
synonym: "protoporphyrinogen IX formation from glycine" EXACT []
synonym: "protoporphyrinogen IX synthesis from glycine" EXACT []
is_a: GO:0006544 ! glycine metabolic process
is_a: GO:0006782 ! protoporphyrinogen IX biosynthetic process
is_a: GO:0044711 ! single-organism biosynthetic process

[Term]
id: GO:0019353
name: protoporphyrinogen IX biosynthetic process from glutamate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX from other compounds, including glutamate." [GOC:go_curators]
subset: gosubset_prok
synonym: "protoporphyrinogen IX anabolism from glutamate" EXACT []
synonym: "protoporphyrinogen IX formation from glutamate" EXACT []
synonym: "protoporphyrinogen IX synthesis from glutamate" EXACT []
is_a: GO:0006782 ! protoporphyrinogen IX biosynthetic process
is_a: GO:0033526 ! tetrapyrrole biosynthetic process from glutamate

[Term]
id: GO:0019354
name: siroheme biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of siroheme, a tetrahydroporphyrin with adjacent, reduced pyrrole rings." [ISBN:0198506732]
subset: gosubset_prok
synonym: "sirohaem biosynthesis" EXACT []
synonym: "sirohaem biosynthetic process" EXACT []
synonym: "siroheme anabolism" EXACT []
synonym: "siroheme biosynthesis" EXACT []
synonym: "siroheme formation" EXACT []
synonym: "siroheme synthase activity" RELATED []
synonym: "siroheme synthesis" EXACT []
xref: AraCyc:PWYQT-62
xref: MetaCyc:PWY-5194
is_a: GO:0006783 ! heme biosynthetic process
is_a: GO:0046156 ! siroheme metabolic process

[Term]
id: GO:0019355
name: nicotinamide nucleotide biosynthetic process from aspartate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nicotinamide nucleotide from other compounds, including aspartate." [GOC:go_curators]
subset: gosubset_prok
synonym: "nicotinamide nucleotide anabolism from aspartate" EXACT []
synonym: "nicotinamide nucleotide formation from aspartate" EXACT []
synonym: "nicotinamide nucleotide synthesis from aspartate" EXACT []
is_a: GO:0006531 ! aspartate metabolic process
is_a: GO:0019359 ! nicotinamide nucleotide biosynthetic process

[Term]
id: GO:0019356
name: nicotinate nucleotide biosynthetic process from tryptophan
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nicotinate nucleotide from other compounds, including tryptophan." [GOC:go_curators]
subset: gosubset_prok
synonym: "nicotinate nucleotide anabolism from tryptophan" EXACT []
synonym: "nicotinate nucleotide formation from tryptophan" EXACT []
synonym: "nicotinate nucleotide synthesis from tryptophan" EXACT []
is_a: GO:0006568 ! tryptophan metabolic process
is_a: GO:0019357 ! nicotinate nucleotide biosynthetic process

[Term]
id: GO:0019357
name: nicotinate nucleotide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nicotinamide nucleotides, any nucleotide that contains combined nicotinate (pyridine 3-carboxylic acid)." [GOC:go_curators]
subset: gosubset_prok
synonym: "nicotinate nucleotide anabolism" EXACT []
synonym: "nicotinate nucleotide biosynthesis" EXACT []
synonym: "nicotinate nucleotide formation" EXACT []
synonym: "nicotinate nucleotide synthesis" EXACT []
is_a: GO:0019363 ! pyridine nucleotide biosynthetic process
is_a: GO:0046497 ! nicotinate nucleotide metabolic process

[Term]
id: GO:0019358
name: nicotinate nucleotide salvage
namespace: biological_process
def: "The generation of nicotinate nucleotide without de novo synthesis." [GOC:go_curators]
subset: gosubset_prok
synonym: "nicotinate nucleotide biosynthesis, salvage pathway" EXACT []
synonym: "nicotinate nucleotide biosynthetic process, salvage pathway" EXACT []
xref: MetaCyc:PWY-5381
xref: MetaCyc:PYRIDNUCSAL-PWY
is_a: GO:0019357 ! nicotinate nucleotide biosynthetic process
is_a: GO:0019365 ! pyridine nucleotide salvage

[Term]
id: GO:0019359
name: nicotinamide nucleotide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nicotinamide nucleotides, any nucleotide that contains combined nicotinamide." [GOC:go_curators]
subset: gosubset_prok
synonym: "nicotinamide nucleotide anabolism" EXACT []
synonym: "nicotinamide nucleotide biosynthesis" EXACT []
synonym: "nicotinamide nucleotide formation" EXACT []
synonym: "nicotinamide nucleotide synthesis" EXACT []
is_a: GO:0019363 ! pyridine nucleotide biosynthetic process
is_a: GO:0046496 ! nicotinamide nucleotide metabolic process

[Term]
id: GO:0019360
name: nicotinamide nucleotide biosynthetic process from niacinamide
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nicotinamide nucleotide from other compounds, including niacinamide." [GOC:go_curators]
subset: gosubset_prok
synonym: "nicotinamide nucleotide anabolism from niacinamide" EXACT []
synonym: "nicotinamide nucleotide formation from niacinamide" EXACT []
synonym: "nicotinamide nucleotide synthesis from niacinamide" EXACT []
is_a: GO:0006769 ! nicotinamide metabolic process
is_a: GO:0019359 ! nicotinamide nucleotide biosynthetic process

[Term]
id: GO:0019361
name: 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA, a derivative of coenzyme A." [GOC:ai]
subset: gosubset_prok
synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA anabolism" EXACT []
synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA biosynthesis" EXACT []
synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA formation" EXACT []
synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA synthesis" EXACT []
xref: MetaCyc:P2-PWY
is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0009152 ! purine ribonucleotide biosynthetic process
is_a: GO:0009168 ! purine ribonucleoside monophosphate biosynthetic process
is_a: GO:0046129 ! purine ribonucleoside biosynthetic process
is_a: GO:0046432 ! 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA metabolic process

[Term]
id: GO:0019362
name: pyridine nucleotide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base." [GOC:jl]
subset: gosubset_prok
synonym: "pyridine nucleotide metabolism" EXACT []
is_a: GO:0006733 ! oxidoreduction coenzyme metabolic process
is_a: GO:0009117 ! nucleotide metabolic process
is_a: GO:0072524 ! pyridine-containing compound metabolic process

[Term]
id: GO:0019363
name: pyridine nucleotide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base." [GOC:jl, GOC:pde, GOC:vw]
subset: gosubset_prok
synonym: "pyridine nucleotide anabolism" EXACT []
synonym: "pyridine nucleotide biosynthesis" EXACT []
synonym: "pyridine nucleotide formation" EXACT []
synonym: "pyridine nucleotide synthesis" EXACT []
xref: MetaCyc:PYRIDNUCSYN-PWY
is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0009165 ! nucleotide biosynthetic process
is_a: GO:0019362 ! pyridine nucleotide metabolic process
is_a: GO:0072525 ! pyridine-containing compound biosynthetic process

[Term]
id: GO:0019364
name: pyridine nucleotide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base." [GOC:jl, GOC:pde, GOC:vw]
subset: gosubset_prok
synonym: "pyridine nucleotide breakdown" EXACT []
synonym: "pyridine nucleotide catabolism" EXACT []
synonym: "pyridine nucleotide degradation" EXACT []
is_a: GO:0009109 ! coenzyme catabolic process
is_a: GO:0009166 ! nucleotide catabolic process
is_a: GO:0019362 ! pyridine nucleotide metabolic process
is_a: GO:0072526 ! pyridine-containing compound catabolic process

[Term]
id: GO:0019365
name: pyridine nucleotide salvage
namespace: biological_process
def: "Any process that generates a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base, from derivatives of them without de novo synthesis." [GOC:jl]
subset: gosubset_prok
synonym: "pyridine nucleotide cycling" EXACT []
is_a: GO:0019363 ! pyridine nucleotide biosynthetic process
is_a: GO:0043173 ! nucleotide salvage

[Term]
id: GO:0019367
name: fatty acid elongation, saturated fatty acid
namespace: biological_process
def: "Elongation of a saturated fatty acid chain." [GOC:mah]
subset: gosubset_prok
xref: MetaCyc:FASYN-ELONG-PWY
is_a: GO:0030497 ! fatty acid elongation

[Term]
id: GO:0019368
name: fatty acid elongation, unsaturated fatty acid
namespace: biological_process
def: "Elongation of a fatty acid chain into which one or more C-C double bonds have been introduced." [GOC:mah]
subset: gosubset_prok
xref: MetaCyc:PWY0-862
is_a: GO:0030497 ! fatty acid elongation

[Term]
id: GO:0019369
name: arachidonic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer." [ISBN:0198506732]
subset: gosubset_prok
synonym: "arachidonic acid metabolism" EXACT []
xref: Wikipedia:Arachidonic_acid
is_a: GO:0001676 ! long-chain fatty acid metabolic process
is_a: GO:0006690 ! icosanoid metabolic process
is_a: GO:0033559 ! unsaturated fatty acid metabolic process

[Term]
id: GO:0019370
name: leukotriene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "leukotriene anabolism" EXACT []
synonym: "leukotriene biosynthesis" EXACT []
synonym: "leukotriene formation" EXACT []
synonym: "leukotriene synthesis" EXACT []
xref: Reactome:REACT_100269 "Leukotriene synthesis, Dictyostelium discoideum"
xref: Reactome:REACT_101902 "Leukotriene synthesis, Taeniopygia guttata"
xref: Reactome:REACT_103938 "Leukotriene synthesis, Rattus norvegicus"
xref: Reactome:REACT_113490 "Leukotriene synthesis, Mycobacterium tuberculosis"
xref: Reactome:REACT_15354 "Leukotriene synthesis, Homo sapiens"
xref: Reactome:REACT_30692 "Leukotriene synthesis, Schizosaccharomyces pombe"
xref: Reactome:REACT_31047 "Leukotriene synthesis, Saccharomyces cerevisiae"
xref: Reactome:REACT_77711 "Leukotriene synthesis, Canis familiaris"
xref: Reactome:REACT_79214 "Leukotriene synthesis, Arabidopsis thaliana"
xref: Reactome:REACT_80693 "Leukotriene synthesis, Danio rerio"
xref: Reactome:REACT_81181 "Leukotriene synthesis, Caenorhabditis elegans"
xref: Reactome:REACT_84742 "Leukotriene synthesis, Xenopus tropicalis"
xref: Reactome:REACT_86207 "Leukotriene synthesis, Escherichia coli"
xref: Reactome:REACT_86282 "Leukotriene synthesis, Drosophila melanogaster"
xref: Reactome:REACT_87550 "Leukotriene synthesis, Sus scrofa"
xref: Reactome:REACT_89496 "Leukotriene synthesis, Mus musculus"
xref: Reactome:REACT_95233 "Leukotriene synthesis, Gallus gallus"
xref: Reactome:REACT_95836 "Leukotriene synthesis, Oryza sativa"
xref: Reactome:REACT_98421 "Leukotriene synthesis, Bos taurus"
xref: Wikipedia:Leukotriene#Leukotriene_synthesis
is_a: GO:0006636 ! unsaturated fatty acid biosynthetic process
is_a: GO:0006691 ! leukotriene metabolic process
is_a: GO:0046456 ! icosanoid biosynthetic process

[Term]
id: GO:0019371
name: cyclooxygenase pathway
namespace: biological_process
def: "The chemical reactions and pathways by which prostaglandins are formed from arachidonic acid, and in which prostaglandin-endoperoxide synthase (cyclooxygenase) catalyzes the committed step in the conversion of arachidonic acid to the prostaglandin-endoperoxides PGG2 and PGH2." [PMID:19854273]
subset: gosubset_prok
is_a: GO:0019369 ! arachidonic acid metabolic process
relationship: part_of GO:0001516 ! prostaglandin biosynthetic process

[Term]
id: GO:0019372
name: lipoxygenase pathway
namespace: biological_process
def: "The chemical reactions and pathways by which an unsaturated fatty acid (such as arachidonic acid or linolenic acid) is converted to other compounds, and in which the first step is hydroperoxide formation catalyzed by lipoxygenase." [GOC:mah, PMID:17163881]
subset: gosubset_prok
is_a: GO:0006631 ! fatty acid metabolic process
is_a: GO:0006690 ! icosanoid metabolic process

[Term]
id: GO:0019373
name: epoxygenase P450 pathway
namespace: biological_process
def: "The chemical reactions and pathways by which arachidonic acid is converted to other compounds including epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids." [GOC:mah, PMID:17979511]
subset: gosubset_prok
is_a: GO:0019369 ! arachidonic acid metabolic process

[Term]
id: GO:0019374
name: galactolipid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving galactolipids, any glycolipid containing one of more residues of galactose and/or N-acetylgalactosamine." [ISBN:0198506732]
subset: gosubset_prok
synonym: "galactolipid metabolism" EXACT []
is_a: GO:0006664 ! glycolipid metabolic process

[Term]
id: GO:0019375
name: galactolipid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of galactolipids, any glycolipid containing one of more residues of galactose and/or N-acetylgalactosamine." [ISBN:0198506732]
subset: gosubset_prok
synonym: "galactolipid anabolism" EXACT []
synonym: "galactolipid biosynthesis" EXACT []
synonym: "galactolipid formation" EXACT []
synonym: "galactolipid synthesis" EXACT []
is_a: GO:0009247 ! glycolipid biosynthetic process
is_a: GO:0019374 ! galactolipid metabolic process

[Term]
id: GO:0019376
name: galactolipid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of galactolipids, any glycolipid containing one of more residues of galactose and/or N-acetylgalactosamine." [ISBN:0198506732]
subset: gosubset_prok
synonym: "galactolipid breakdown" EXACT []
synonym: "galactolipid catabolism" EXACT []
synonym: "galactolipid degradation" EXACT []
is_a: GO:0019374 ! galactolipid metabolic process
is_a: GO:0019377 ! glycolipid catabolic process

[Term]
id: GO:0019377
name: glycolipid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide)." [CHEBI:33563, GOC:go_curators]
subset: gosubset_prok
synonym: "glycolipid breakdown" EXACT []
synonym: "glycolipid catabolism" EXACT []
synonym: "glycolipid degradation" EXACT []
is_a: GO:0006664 ! glycolipid metabolic process
is_a: GO:0046466 ! membrane lipid catabolic process
is_a: GO:1901136 ! carbohydrate derivative catabolic process

[Term]
id: GO:0019379
name: sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)
namespace: biological_process
def: "The pathway by which inorganic sulfate is processed and incorporated into sulfated compounds, where the phosphoadenylyl sulfate reduction step is catalyzed by the enzyme phosphoadenylyl-sulfate reductase (thioredoxin) (EC:1.8.4.8)." [GOC:jl]
subset: gosubset_prok
synonym: "sulphate assimilation, phosphoadenylyl sulphate reduction by a phosphoadenylyl-sulphate reductase (thioredoxin)" EXACT []
xref: MetaCyc:SO4ASSIM-PWY
is_a: GO:0000103 ! sulfate assimilation
is_a: GO:0019419 ! sulfate reduction

[Term]
id: GO:0019380
name: 3-phenylpropionate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 3-phenylpropionate, the anion of phenylpropanoic acid." [GOC:ai]
subset: gosubset_prok
synonym: "3-phenylpropionate breakdown" EXACT []
synonym: "3-phenylpropionate catabolism" EXACT []
synonym: "3-phenylpropionate degradation" EXACT []
xref: MetaCyc:HCAMHPDEG-PWY
xref: MetaCyc:P281-PWY
is_a: GO:0018962 ! 3-phenylpropionate metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process

[Term]
id: GO:0019381
name: atrazine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide." [GOC:jl, UM-BBD_pathwayID:atr]
subset: gosubset_prok
synonym: "atrazine breakdown" EXACT []
synonym: "atrazine catabolism" EXACT []
synonym: "atrazine degradation" EXACT []
xref: MetaCyc:P141-PWY
is_a: GO:0018873 ! atrazine metabolic process
is_a: GO:0042204 ! s-triazine compound catabolic process

[Term]
id: GO:0019382
name: carbon tetrachloride catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of carbon tetrachloride, a toxic, carcinogenic compound which is used as a general solvent in industrial degreasing operations. It is also used as grain fumigant and a chemical intermediate in the production of refrigerants." [GOC:go_curators]
subset: gosubset_prok
synonym: "carbon tetrachloride breakdown" EXACT []
synonym: "carbon tetrachloride catabolism" EXACT []
synonym: "carbon tetrachloride degradation" EXACT []
is_a: GO:0018885 ! carbon tetrachloride metabolic process
is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process

[Term]
id: GO:0019383
name: (+)-camphor catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of (+)-camphor, a bicyclic monoterpene ketone." [UM-BBD_pathwayID:cam]
subset: gosubset_prok
synonym: "(+)-camphor breakdown" EXACT []
synonym: "(+)-camphor catabolism" EXACT []
synonym: "(+)-camphor degradation" EXACT []
xref: MetaCyc:P601-PWY
is_a: GO:0016100 ! monoterpenoid catabolic process
is_a: GO:0018882 ! (+)-camphor metabolic process
is_a: GO:0042182 ! ketone catabolic process

[Term]
id: GO:0019384
name: caprolactam catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of caprolactam, hexahydro-2h-azepin-2-one, a cyclic amide of caproic acid." [CHEBI:23000, GOC:curators]
subset: gosubset_prok
synonym: "caprolactam breakdown" EXACT []
synonym: "caprolactam catabolism" EXACT []
synonym: "caprolactam degradation" EXACT []
xref: MetaCyc:P621-PWY
is_a: GO:0018883 ! caprolactam metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0072340 ! cellular lactam catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process

[Term]
id: GO:0019385
name: methanogenesis, from acetate
namespace: biological_process
def: "The formation of methane, a colorless, odorless, flammable gas with the formula CH4, from other components, including acetate." [GOC:ai]
subset: gosubset_prok
synonym: "methane biosynthesis from acetate" EXACT []
synonym: "methane biosynthetic process from acetate" EXACT []
xref: MetaCyc:METH-ACETATE-PWY
is_a: GO:0006083 ! acetate metabolic process
is_a: GO:0015948 ! methanogenesis

[Term]
id: GO:0019386
name: methanogenesis, from carbon dioxide
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of methane, a colorless, odorless, flammable gas with the formula CH4, from other compounds, including carbon dioxide (CO2)." [GOC:ai]
subset: gosubset_prok
synonym: "methane biosynthesis from carbon dioxide" EXACT []
synonym: "methane biosynthetic process from carbon dioxide" EXACT []
xref: MetaCyc:METHANOGENESIS-PWY
is_a: GO:0015948 ! methanogenesis

[Term]
id: GO:0019387
name: methanogenesis, from methanol
namespace: biological_process
def: "The formation of methane, a colorless, odorless, flammable gas with the formula CH4, from other components, including methanol." [GOC:ai]
subset: gosubset_prok
synonym: "methane biosynthesis from methanol" EXACT []
synonym: "methane biosynthetic process from methanol" EXACT []
xref: MetaCyc:METHFORM-PWY
is_a: GO:0015945 ! methanol metabolic process
is_a: GO:0015948 ! methanogenesis

[Term]
id: GO:0019388
name: galactose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of galactose, the aldohexose galacto-hexose." [ISBN:0198506732]
subset: gosubset_prok
synonym: "galactose breakdown" EXACT []
synonym: "galactose catabolism" EXACT []
synonym: "galactose degradation" EXACT []
xref: MetaCyc:GALDEG-PWY
xref: Reactome:REACT_101671 "Galactose catabolism, Danio rerio"
xref: Reactome:REACT_102662 "Galactose catabolism, Rattus norvegicus"
xref: Reactome:REACT_103750 "Galactose catabolism, Drosophila melanogaster"
xref: Reactome:REACT_105986 "Galactose catabolism, Caenorhabditis elegans"
xref: Reactome:REACT_107846 "Galactose catabolism, Staphylococcus aureus N315"
xref: Reactome:REACT_109622 "Galactose catabolism, Escherichia coli"
xref: Reactome:REACT_110591 "Galactose catabolism, Gallus gallus"
xref: Reactome:REACT_28686 "Galactose catabolism, Bos taurus"
xref: Reactome:REACT_33886 "Galactose catabolism, Sus scrofa"
xref: Reactome:REACT_532 "Galactose catabolism, Homo sapiens"
xref: Reactome:REACT_81224 "Galactose catabolism, Dictyostelium discoideum"
xref: Reactome:REACT_83466 "Galactose catabolism, Oryza sativa"
xref: Reactome:REACT_83824 "Galactose catabolism, Canis familiaris"
xref: Reactome:REACT_85434 "Galactose catabolism, Saccharomyces cerevisiae"
xref: Reactome:REACT_86003 "Galactose catabolism, Mycobacterium tuberculosis"
xref: Reactome:REACT_92086 "Galactose catabolism, Arabidopsis thaliana"
xref: Reactome:REACT_93309 "Galactose catabolism, Taeniopygia guttata"
xref: Reactome:REACT_94697 "Galactose catabolism, Schizosaccharomyces pombe"
xref: Reactome:REACT_95523 "Galactose catabolism, Mus musculus"
xref: Reactome:REACT_98723 "Galactose catabolism, Xenopus tropicalis"
is_a: GO:0006012 ! galactose metabolic process
is_a: GO:0019320 ! hexose catabolic process

[Term]
id: GO:0019389
name: glucuronoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glucuronosides, any compound formed by combination in glycosidic linkage of a hydroxy compound with the anomeric carbon atom of a glucuronate." [ISBN:0198506732]
subset: gosubset_prok
synonym: "glucuronide metabolic process" EXACT []
synonym: "glucuronide metabolism" EXACT []
synonym: "glucuronoside metabolism" EXACT []
is_a: GO:0016137 ! glycoside metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process
is_a: GO:0044262 ! cellular carbohydrate metabolic process
is_a: GO:0044723 ! single-organism carbohydrate metabolic process

[Term]
id: GO:0019390
name: glucuronoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glucuronosides, compound composed of a hydroxy compound linked to a glucuronate residue." [ISBN:0198506732]
subset: gosubset_prok
synonym: "glucuronide biosynthesis" EXACT []
synonym: "glucuronide biosynthetic process" EXACT []
synonym: "glucuronoside anabolism" EXACT []
synonym: "glucuronoside biosynthesis" EXACT []
synonym: "glucuronoside formation" EXACT []
synonym: "glucuronoside synthesis" EXACT []
is_a: GO:0016138 ! glycoside biosynthetic process
is_a: GO:0019389 ! glucuronoside metabolic process
is_a: GO:0034637 ! cellular carbohydrate biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process

[Term]
id: GO:0019391
name: glucuronoside catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glucuronosides, compound composed of a hydroxy compound linked to a glucuronate residue." [ISBN:0198506732]
subset: gosubset_prok
synonym: "glucuronide catabolic process" EXACT []
synonym: "glucuronide catabolism" EXACT []
synonym: "glucuronoside breakdown" EXACT []
synonym: "glucuronoside catabolism" EXACT []
synonym: "glucuronoside degradation" EXACT []
xref: MetaCyc:GLUCUROCAT-PWY
is_a: GO:0016139 ! glycoside catabolic process
is_a: GO:0019389 ! glucuronoside metabolic process
is_a: GO:0044275 ! cellular carbohydrate catabolic process
is_a: GO:0044724 ! single-organism carbohydrate catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process

[Term]
id: GO:0019392
name: glucarate metabolic process
namespace: biological_process
alt_id: GO:0019581
def: "The chemical reactions and pathways involving glucarate, the dianion of glucaric acid, an aldaric acid derived from either glucose or gulose. There are two enantiomers L- and D-glucarate." [ISBN:0198506732]
subset: gosubset_prok
synonym: "glucarate metabolism" EXACT []
is_a: GO:0019577 ! aldaric acid metabolic process

[Term]
id: GO:0019393
name: glucarate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glucarate, the anion of glucaric acid." [ISBN:0198506732]
subset: gosubset_prok
synonym: "glucarate anabolism" EXACT []
synonym: "glucarate biosynthesis" EXACT []
synonym: "glucarate formation" EXACT []
synonym: "glucarate synthesis" EXACT []
is_a: GO:0019392 ! glucarate metabolic process
is_a: GO:0019578 ! aldaric acid biosynthetic process

[Term]
id: GO:0019394
name: glucarate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glucarate, the anion of glucaric acid." [ISBN:0198506732]
subset: gosubset_prok
synonym: "glucarate breakdown" EXACT []
synonym: "glucarate catabolism" EXACT []
synonym: "glucarate degradation" EXACT []
xref: MetaCyc:GLUCARDEG-PWY
is_a: GO:0019392 ! glucarate metabolic process
is_a: GO:0019579 ! aldaric acid catabolic process

[Term]
id: GO:0019395
name: fatty acid oxidation
namespace: biological_process
def: "The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen." [ISBN:0198506732, MetaCyc:FAO-PWY]
subset: gosubset_prok
xref: MetaCyc:FAO-PWY
is_a: GO:0006631 ! fatty acid metabolic process
is_a: GO:0034440 ! lipid oxidation

[Term]
id: GO:0019396
name: gallate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid (3,4,5-trihydroxybenzoic acid)." [GOC:jl]
subset: gosubset_prok
synonym: "gallate breakdown" EXACT []
synonym: "gallate catabolism" EXACT []
synonym: "gallate degradation" EXACT []
synonym: "gallic acid catabolic process" EXACT []
synonym: "gallic acid catabolism" EXACT []
is_a: GO:0018918 ! gallate metabolic process
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0019397
name: gallate catabolic process via 2-pyrone-4,6-dicarboxylate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid, via the intermediate 2-pyrone-4,6-dicarboxylate." [GOC:jl]
subset: gosubset_prok
synonym: "gallate breakdown via 2-pyrone-4,6-dicarboxylate" EXACT []
synonym: "gallate degradation via 2-pyrone-4,6-dicarboxylate" EXACT []
synonym: "gallic acid catabolic process via 2-pyrone-4,6-dicarboxylate" EXACT []
synonym: "gallic acid catabolism via 2-pyrone-4,6-dicarboxylate" EXACT []
xref: MetaCyc:GALLATE-DEGRADATION-I-PWY
is_a: GO:0042195 ! aerobic gallate catabolic process

[Term]
id: GO:0019398
name: gallate catabolic process via gallate dioxygenase activity
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid, where the first step is the conversion of gallate to (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate catalyzed by gallate dioxygenase." [GOC:bf, GOC:jl]
subset: gosubset_prok
synonym: "gallate breakdown via 4-carboxy-2-hydroxhexa-2,3-dienedioate" EXACT []
synonym: "gallate catabolic process via 4-carboxy-2-hydroxhexa-2,3-dienedioate" BROAD [GOC:bf]
synonym: "gallate degradation via 4-carboxy-2-hydroxhexa-2,3-dienedioate" EXACT []
synonym: "gallic acid catabolic process via 4-carboxy-2-hydroxhexa-2,3-dienedioate" EXACT []
synonym: "gallic acid catabolism via 4-carboxy-2-hydroxhexa-2,3-dienedioate" EXACT []
xref: MetaCyc:GALLATE-DEGRADATION-II-PWY
is_a: GO:0042195 ! aerobic gallate catabolic process
relationship: has_part GO:0036238 ! gallate dioxygenase activity

[Term]
id: GO:0019399
name: cyclohexanol oxidation
namespace: biological_process
def: "The cyclohexanol metabolic process in which cyclohexanol is converted to adipate." [MetaCyc:CYCLOHEXANOL-OXIDATION-PWY]
subset: gosubset_prok
xref: MetaCyc:CYCLOHEXANOL-OXIDATION-PWY
is_a: GO:0018891 ! cyclohexanol metabolic process
is_a: GO:0055114 ! oxidation-reduction process

[Term]
id: GO:0019400
name: alditol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group." [ISBN:0198506732]
subset: gosubset_prok
synonym: "alditol metabolism" EXACT []
is_a: GO:0019751 ! polyol metabolic process
is_a: GO:0044262 ! cellular carbohydrate metabolic process
is_a: GO:0044723 ! single-organism carbohydrate metabolic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0019401
name: alditol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group." [ISBN:0198506732]
subset: gosubset_prok
synonym: "alditol anabolism" EXACT []
synonym: "alditol biosynthesis" EXACT []
synonym: "alditol formation" EXACT []
synonym: "alditol synthesis" EXACT []
is_a: GO:0019400 ! alditol metabolic process
is_a: GO:0034637 ! cellular carbohydrate biosynthetic process
is_a: GO:0046173 ! polyol biosynthetic process

[Term]
id: GO:0019402
name: galactitol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving galactitol, the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose." [ISBN:0198506732]
subset: gosubset_prok
synonym: "galactitol metabolism" EXACT []
is_a: GO:0006059 ! hexitol metabolic process

[Term]
id: GO:0019403
name: galactitol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of galactitol, the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose." [ISBN:0198506732]
subset: gosubset_prok
synonym: "galactitol anabolism" EXACT []
synonym: "galactitol biosynthesis" EXACT []
synonym: "galactitol formation" EXACT []
synonym: "galactitol synthesis" EXACT []
is_a: GO:0019402 ! galactitol metabolic process
is_a: GO:0019406 ! hexitol biosynthetic process

[Term]
id: GO:0019404
name: galactitol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of galactitol, the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose." [ISBN:0198506732]
subset: gosubset_prok
synonym: "galactitol breakdown" EXACT []
synonym: "galactitol catabolism" EXACT []
synonym: "galactitol degradation" EXACT []
xref: MetaCyc:GALACTITOLCAT-PWY
is_a: GO:0019402 ! galactitol metabolic process
is_a: GO:0019407 ! hexitol catabolic process

[Term]
id: GO:0019405
name: alditol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group." [ISBN:0198506732]
subset: gosubset_prok
synonym: "alditol breakdown" EXACT []
synonym: "alditol catabolism" EXACT []
synonym: "alditol degradation" EXACT []
is_a: GO:0019400 ! alditol metabolic process
is_a: GO:0044275 ! cellular carbohydrate catabolic process
is_a: GO:0044724 ! single-organism carbohydrate catabolic process
is_a: GO:0046174 ! polyol catabolic process

[Term]
id: GO:0019406
name: hexitol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of hexitols, any alditol with a chain of six carbon atoms in the molecule." [ISBN:0198506732]
subset: gosubset_prok
synonym: "hexitol anabolism" EXACT []
synonym: "hexitol biosynthesis" EXACT []
synonym: "hexitol formation" EXACT []
synonym: "hexitol synthesis" EXACT []
is_a: GO:0006059 ! hexitol metabolic process
is_a: GO:0019401 ! alditol biosynthetic process

[Term]
id: GO:0019407
name: hexitol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of hexitols, any alditol with a chain of six carbon atoms in the molecule." [ISBN:0198506732]
subset: gosubset_prok
synonym: "hexitol breakdown" EXACT []
synonym: "hexitol catabolism" EXACT []
synonym: "hexitol degradation" EXACT []
is_a: GO:0006059 ! hexitol metabolic process
is_a: GO:0019405 ! alditol catabolic process

[Term]
id: GO:0019408
name: dolichol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dolichols, any 2,3-dihydropolyprenol derived from four or more linked isoprene units." [ISBN:0198506732]
synonym: "dolichol anabolism" EXACT []
synonym: "dolichol biosynthesis" EXACT []
synonym: "dolichol formation" EXACT []
synonym: "dolichol synthesis" EXACT []
is_a: GO:0016094 ! polyprenol biosynthetic process
is_a: GO:0019348 ! dolichol metabolic process

[Term]
id: GO:0019409
name: aerobic respiration, using ammonia as electron donor
namespace: biological_process
def: "The metabolic process in which ammonia (NH3) is oxidized to nitrite (NO2) in the presence of oxygen; enzymatic reactions convert ammonia to hydrazine, and hydrazine to nitrite." [MetaCyc:AMMOXID-PWY]
subset: gosubset_prok
synonym: "aerobic ammonia oxidation to nitrite via hydrazine" EXACT [GOC:mah]
xref: MetaCyc:AMMOXID-PWY
is_a: GO:0009060 ! aerobic respiration
is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds
is_a: GO:0019329 ! ammonia oxidation
is_a: GO:0034641 ! cellular nitrogen compound metabolic process

[Term]
id: GO:0019410
name: aerobic respiration, using carbon monoxide as electron donor
namespace: biological_process
def: "The metabolic process in which carbon monoxide (CO) is oxidized to carbon dioxide (CO2) to generate energy. Conservation of energy in this process likely uses sodium ion gradients for ATP synthesis and is coupled to quantitative sulfide methylation." [PMID:18024677]
subset: gosubset_prok
is_a: GO:0009060 ! aerobic respiration
is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds

[Term]
id: GO:0019411
name: aerobic respiration, using ferrous ions as electron donor
namespace: biological_process
def: "The metabolic process in which ferrous ions (Fe2+) are oxidized to ferric ions (Fe3+) to generate energy, coupled to the reduction of carbon dioxide." [ISBN:3131084111]
subset: gosubset_prok
is_a: GO:0009060 ! aerobic respiration
is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds

[Term]
id: GO:0019412
name: aerobic respiration, using hydrogen as electron donor
namespace: biological_process
def: "The oxidation of hydrogen (H2) to water (H2O), using oxygen (O2) as the electron acceptor. A hydrogenase enzyme binds H2 and the hydrogen atoms are passed through an electron transfer chain to O2 to form water." [MetaCyc:P283-PWY]
subset: gosubset_prok
synonym: "hydrogen oxidation" BROAD []
xref: MetaCyc:P283-PWY
is_a: GO:0009060 ! aerobic respiration
is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds

[Term]
id: GO:0019413
name: acetate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of acetate, the anion of acetic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "acetate anabolism" EXACT []
synonym: "acetate biosynthesis" EXACT []
synonym: "acetate formation" EXACT []
synonym: "acetate synthesis" EXACT []
is_a: GO:0006083 ! acetate metabolic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process

[Term]
id: GO:0019414
name: aerobic respiration, using sulfur or sulfate as electron donor
namespace: biological_process
def: "An aerobic respiration process in which a sulfur-containing molecule (hydrogen sulfide, sulfur, sulfite, thiosulfate, and various polythionates) is oxidized." [PMID:11425697]
subset: gosubset_prok
synonym: "aerobic respiration, using sulphur or sulphate as electron donor" EXACT []
is_a: GO:0009060 ! aerobic respiration
is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds

[Term]
id: GO:0019415
name: acetate biosynthetic process from carbon monoxide
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of acetate from other compounds, including carbon monoxide." [GOC:go_curators]
subset: gosubset_prok
synonym: "acetate anabolism from carbon monoxide" EXACT []
synonym: "acetate formation from carbon monoxide" EXACT []
synonym: "acetate synthesis from carbon monoxide" EXACT []
synonym: "carbon monoxide dehydrogenase pathway" EXACT []
xref: MetaCyc:CODH-PWY
is_a: GO:0019413 ! acetate biosynthetic process

[Term]
id: GO:0019416
name: polythionate oxidation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the conversion of thiosulfate to tetrathionate, using cytochrome c as an electron acceptor." [MetaCyc:THIOSULFOX-PWY]
subset: gosubset_prok
xref: MetaCyc:THIOSULFOX-PWY
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0055114 ! oxidation-reduction process

[Term]
id: GO:0019417
name: sulfur oxidation
namespace: biological_process
def: "The chemical reactions and pathways resulting the addition of oxygen to elemental sulfur." [GOC:jl, MetaCyc:FESULFOX-PWY, MetaCyc:SULFUROX-PWY]
subset: gosubset_prok
synonym: "sulphur oxidation" EXACT []
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0055114 ! oxidation-reduction process

[Term]
id: GO:0019418
name: sulfide oxidation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the conversion of sulfide to elemental sulfur in a higher oxidation state, or to sulfite or sulfate." [MetaCyc:P222-PWY, MetaCyc:P223-PWY, MetaCyc:PWY-5274, MetaCyc:PWY-5285]
subset: gosubset_prok
synonym: "sulphide oxidation" EXACT []
xref: MetaCyc:P222-PWY
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0055114 ! oxidation-reduction process

[Term]
id: GO:0019419
name: sulfate reduction
namespace: biological_process
alt_id: GO:0019421
def: "The chemical reactions and pathways resulting in the reduction of sulfate to another sulfur-containing ion or compound such as hydrogen sulfide, adenosine-phosphosulfate (APS) or thiosulfate." [MetaCyc:DISSULFRED-PWY, MetaCyc:P224-PWY, MetaCyc:SO4ASSIM-PWY, MetaCyc:SULFMETII-PWY]
subset: gosubset_prok
synonym: "assimilatory sulfate reduction" NARROW []
synonym: "assimilatory sulphate reduction" NARROW []
synonym: "sulfate reduction, APS pathway" NARROW []
synonym: "sulphate reduction" EXACT []
synonym: "sulphate reduction, APS pathway" NARROW []
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0055114 ! oxidation-reduction process

[Term]
id: GO:0019420
name: dissimilatory sulfate reduction
namespace: biological_process
def: "The reduction of sulfate to hydrogen sulfide, which acts as a terminal electron acceptor. Sulfate is activated to adenosine-phosphosulfate (APS) which is then reduced to sulfite, which is in turn reduced to hydrogen sulfide." [GOC:jl, MetaCyc:DISSULFRED-PWY]
subset: gosubset_prok
synonym: "dissimilatory sulphate reduction" EXACT []
xref: MetaCyc:DISSULFRED-PWY
is_a: GO:0019419 ! sulfate reduction

[Term]
id: GO:0019422
name: disproportionation of elemental sulfur
namespace: biological_process
def: "The process in which sulfur compounds with an intermediate oxidation state serve as both electron donors and electron acceptors in an energy-generating redox process. The reaction takes place anaerobically, in light and in the absence of CO2." [MetaCyc:P203-PWY]
subset: gosubset_prok
synonym: "disproportionation of elemental sulphur" EXACT []
xref: MetaCyc:P203-PWY
is_a: GO:0006790 ! sulfur compound metabolic process

[Term]
id: GO:0019423
name: sulfur oxidation, ferric ion-dependent
namespace: biological_process
def: "A sulfur oxidation process that proceeds via the reaction catalyzed by sulfur:ferric ion oxidoreductase, and requires the presence of ferric ion (Fe3+)." [MetaCyc:FESULFOX-PWY]
subset: gosubset_prok
synonym: "sulphur oxidation, ferric ion-dependent" EXACT []
xref: MetaCyc:FESULFOX-PWY
is_a: GO:0019417 ! sulfur oxidation

[Term]
id: GO:0019424
name: sulfide oxidation, using siroheme sulfite reductase
namespace: biological_process
alt_id: GO:0019425
def: "A sulfide oxidation process that proceeds via the reaction catalyzed by siroheme sulfite reductase." [MetaCyc:P223-PWY]
subset: gosubset_prok
synonym: "sulfide oxidation, using sirohaem sulfite reductase" EXACT []
synonym: "sulfur oxidation, using sirohaem sulfite reductase" RELATED []
synonym: "sulfur oxidation, using siroheme sulfite reductase" RELATED []
synonym: "sulphide oxidation, using siroheme sulphite reductase" EXACT []
synonym: "sulphur oxidation, using siroheme sulphite reductase" RELATED []
xref: MetaCyc:P223-PWY
is_a: GO:0019418 ! sulfide oxidation

[Term]
id: GO:0019426
name: bisulfite reduction
namespace: biological_process
def: "The chemical reactions and pathways resulting in the reduction of sulfate to thiosulfate via bisulfite." [MetaCyc:P224-PWY]
subset: gosubset_prok
synonym: "bisulphite reduction" EXACT []
xref: MetaCyc:P224-PWY
is_a: GO:0019419 ! sulfate reduction

[Term]
id: GO:0019427
name: acetyl-CoA biosynthetic process from acetate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of acetyl-CoA from acetate, either directly or via acetylphosphate." [MetaCyc:ACETATEUTIL-PWY]
subset: gosubset_prok
synonym: "acetate utilization" RELATED []
synonym: "acetyl-CoA anabolism from acetate" EXACT []
synonym: "acetyl-CoA formation from acetate" EXACT []
synonym: "acetyl-CoA synthesis from acetate" EXACT []
xref: MetaCyc:ACETATEUTIL-PWY
is_a: GO:0006083 ! acetate metabolic process
is_a: GO:0006085 ! acetyl-CoA biosynthetic process
is_a: GO:0044711 ! single-organism biosynthetic process

[Term]
id: GO:0019428
name: allantoin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of allantoin, (2,5-dioxo-4-imidazolidinyl)urea." [GOC:go_curators]
subset: gosubset_prok
synonym: "allantoin anabolism" EXACT []
synonym: "allantoin biosynthesis" EXACT []
synonym: "allantoin formation" EXACT []
synonym: "allantoin synthesis" EXACT []
xref: MetaCyc:URSIN-PWY
is_a: GO:0000255 ! allantoin metabolic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process

[Term]
id: GO:0019429
name: fluorene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of fluorene, a tricyclic polycyclic aromatic hydrocarbon containing a five-membered ring. It is a major component of fossil fuels and their derivatives and is also a by-product of coal-conversion and energy-related industries. It is commonly found in vehicle exhaust emissions, crude oils, motor oils, coal and oil combustion products, waste incineration, and industrial effluents." [GOC:go_curators]
subset: gosubset_prok
synonym: "fluorene breakdown" EXACT []
synonym: "fluorene catabolism" EXACT []
synonym: "fluorene degradation" EXACT []
xref: MetaCyc:FLUORENE-DEG-9-ONE-PWY
is_a: GO:0018917 ! fluorene metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process

[Term]
id: GO:0019430
name: removal of superoxide radicals
namespace: biological_process
def: "Any process, acting at the cellular level, involved in removing superoxide radicals (O2-) from a cell or organism, e.g. by conversion to dioxygen (O2) and hydrogen peroxide (H2O2)." [CHEBI:18421, GOC:jl]
subset: gosubset_prok
synonym: "cellular detoxification of superoxide radicals" EXACT [GOC:dos]
synonym: "removal of O2-" EXACT []
synonym: "removal of oxygen free radicals" EXACT []
xref: MetaCyc:DETOX1-PWY
is_a: GO:0006801 ! superoxide metabolic process
is_a: GO:0044710 ! single-organism metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0098869 ! cellular oxidant detoxification
relationship: part_of GO:0071451 ! cellular response to superoxide

[Term]
id: GO:0019431
name: acetyl-CoA biosynthetic process from ethanol
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of acetyl-CoA from ethanol via acetaldehyde." [GOC:go_curators]
subset: gosubset_prok
synonym: "acetyl-CoA anabolism from ethanol" EXACT []
synonym: "acetyl-CoA formation from ethanol" EXACT []
synonym: "acetyl-CoA synthesis from ethanol" EXACT []
xref: MetaCyc:ETOH-ACETYLCOA-ANA-PWY
is_a: GO:0006067 ! ethanol metabolic process
is_a: GO:0006085 ! acetyl-CoA biosynthetic process
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0019432
name: triglyceride biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol." [ISBN:0198506732]
subset: gosubset_prok
synonym: "triacylglycerol biosynthesis" EXACT []
synonym: "triacylglycerol biosynthetic process" EXACT []
synonym: "triglyceride anabolism" EXACT []
synonym: "triglyceride biosynthesis" EXACT []
synonym: "triglyceride formation" EXACT []
synonym: "triglyceride synthesis" EXACT []
xref: MetaCyc:TRIGLSYN-PWY
xref: Reactome:REACT_100326 "Triglyceride Biosynthesis, Mus musculus"
xref: Reactome:REACT_102463 "Triglyceride Biosynthesis, Danio rerio"
xref: Reactome:REACT_102566 "Triglyceride Biosynthesis, Taeniopygia guttata"
xref: Reactome:REACT_104093 "Triglyceride Biosynthesis, Saccharomyces cerevisiae"
xref: Reactome:REACT_106512 "Triglyceride Biosynthesis, Oryza sativa"
xref: Reactome:REACT_107325 "Triglyceride Biosynthesis, Drosophila melanogaster"
xref: Reactome:REACT_107784 "Triglyceride Biosynthesis, Dictyostelium discoideum"
xref: Reactome:REACT_110365 "Triglyceride Biosynthesis, Arabidopsis thaliana"
xref: Reactome:REACT_1190 "Triglyceride Biosynthesis, Homo sapiens"
xref: Reactome:REACT_30474 "Triglyceride Biosynthesis, Mycobacterium tuberculosis"
xref: Reactome:REACT_34309 "Triglyceride Biosynthesis, Sus scrofa"
xref: Reactome:REACT_81292 "Triglyceride Biosynthesis, Xenopus tropicalis"
xref: Reactome:REACT_81530 "Triglyceride Biosynthesis, Schizosaccharomyces pombe"
xref: Reactome:REACT_82183 "Triglyceride Biosynthesis, Plasmodium falciparum"
xref: Reactome:REACT_84161 "Triglyceride Biosynthesis, Bos taurus"
xref: Reactome:REACT_91173 "Triglyceride Biosynthesis, Canis familiaris"
xref: Reactome:REACT_93188 "Triglyceride Biosynthesis, Rattus norvegicus"
xref: Reactome:REACT_95647 "Triglyceride Biosynthesis, Escherichia coli"
xref: Reactome:REACT_96246 "Triglyceride Biosynthesis, Caenorhabditis elegans"
xref: Reactome:REACT_99272 "Triglyceride Biosynthesis, Gallus gallus"
is_a: GO:0006641 ! triglyceride metabolic process
is_a: GO:0046463 ! acylglycerol biosynthetic process

[Term]
id: GO:0019433
name: triglyceride catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a triglyceride, any triester of glycerol." [ISBN:0198506732]
subset: gosubset_prok
synonym: "triacylglycerol catabolic process" EXACT []
synonym: "triacylglycerol catabolism" EXACT []
synonym: "triglyceride breakdown" EXACT []
synonym: "triglyceride catabolism" EXACT []
synonym: "triglyceride degradation" EXACT []
xref: MetaCyc:LIPAS-PWY
xref: Reactome:REACT_100006 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis, Dictyostelium discoideum"
xref: Reactome:REACT_100675 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis, Schizosaccharomyces pombe"
xref: Reactome:REACT_101906 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis, Danio rerio"
xref: Reactome:REACT_110071 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis, Xenopus tropicalis"
xref: Reactome:REACT_112141 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis, Oryza sativa"
xref: Reactome:REACT_114503 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis, Arabidopsis thaliana"
xref: Reactome:REACT_115465 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis, Staphylococcus aureus N315"
xref: Reactome:REACT_494 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis, Homo sapiens"
xref: Reactome:REACT_77926 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis, Gallus gallus"
xref: Reactome:REACT_78891 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis, Rattus norvegicus"
xref: Reactome:REACT_80264 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis, Mycobacterium tuberculosis"
xref: Reactome:REACT_81049 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis, Bos taurus"
xref: Reactome:REACT_81405 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis, Canis familiaris"
xref: Reactome:REACT_83054 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis, Saccharomyces cerevisiae"
xref: Reactome:REACT_83635 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis, Sus scrofa"
xref: Reactome:REACT_84463 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis, Escherichia coli"
xref: Reactome:REACT_89529 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis, Taeniopygia guttata"
xref: Reactome:REACT_92212 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis, Caenorhabditis elegans"
xref: Reactome:REACT_96550 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis, Drosophila melanogaster"
xref: Reactome:REACT_98184 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis, Mus musculus"
is_a: GO:0006641 ! triglyceride metabolic process
is_a: GO:0046464 ! acylglycerol catabolic process

[Term]
id: GO:0019434
name: sophorosyloxydocosanoate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sophorosyloxydocosanoate, 13-sophorosyloxydocosanoate 6',6''-diacetate, an aromatic hydrocarbon." [MetaCyc:DIGLUCODIACETYL-DOCOSANOATE]
subset: gosubset_prok
synonym: "sophorosyloxydocosanoate metabolism" EXACT []
is_a: GO:0006664 ! glycolipid metabolic process

[Term]
id: GO:0019435
name: sophorosyloxydocosanoate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sophorosyloxydocosanoate, 13-sophorosyloxydocosanoate 6',6''-diacetate." [GOC:ai]
subset: gosubset_prok
synonym: "sophorosyloxydocosanoate anabolism" EXACT []
synonym: "sophorosyloxydocosanoate biosynthesis" EXACT []
synonym: "sophorosyloxydocosanoate formation" EXACT []
synonym: "sophorosyloxydocosanoate synthesis" EXACT []
xref: MetaCyc:SOPHOROSYLOXYDOCOSANOATE-SYN-PWY
is_a: GO:0009247 ! glycolipid biosynthetic process
is_a: GO:0019434 ! sophorosyloxydocosanoate metabolic process

[Term]
id: GO:0019436
name: sophorosyloxydocosanoate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of sophorosyloxydocosanoate, 13-sophorosyloxydocosanoate 6',6''-diacetate." [GOC:ai]
subset: gosubset_prok
synonym: "sophorosyloxydocosanoate breakdown" EXACT []
synonym: "sophorosyloxydocosanoate catabolism" EXACT []
synonym: "sophorosyloxydocosanoate degradation" EXACT []
xref: MetaCyc:SOPHOROSYLOXYDOCOSANOATE-DEG-PWY
is_a: GO:0019377 ! glycolipid catabolic process
is_a: GO:0019434 ! sophorosyloxydocosanoate metabolic process

[Term]
id: GO:0019438
name: aromatic compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance containing an aromatic carbon ring." [GOC:ai]
subset: gosubset_prok
synonym: "aromatic compound anabolism" EXACT []
synonym: "aromatic compound biosynthesis" EXACT []
synonym: "aromatic compound formation" EXACT []
synonym: "aromatic compound synthesis" EXACT []
synonym: "aromatic hydrocarbon biosynthesis" NARROW []
synonym: "aromatic hydrocarbon biosynthetic process" NARROW []
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0019439
name: aromatic compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring." [GOC:ai]
subset: gosubset_prok
synonym: "aromatic compound breakdown" EXACT []
synonym: "aromatic compound catabolism" EXACT []
synonym: "aromatic compound degradation" EXACT []
synonym: "aromatic hydrocarbon catabolic process" NARROW []
synonym: "aromatic hydrocarbon catabolism" NARROW []
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0044248 ! cellular catabolic process

[Term]
id: GO:0019440
name: tryptophan catabolic process to indole-3-acetate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including indole-3-acetate." [GOC:go_curators]
subset: gosubset_prok
synonym: "tryptophan breakdown to indole-3-acetate" EXACT []
synonym: "tryptophan catabolic process to IAA" EXACT []
synonym: "tryptophan catabolic process to indoleacetic acid" EXACT []
synonym: "tryptophan catabolism to indoleacetic acid" EXACT []
synonym: "tryptophan degradation to indole-3-acetate" EXACT []
xref: MetaCyc:TRPIAACAT-PWY
is_a: GO:0006569 ! tryptophan catabolic process
is_a: GO:0009683 ! indoleacetic acid metabolic process

[Term]
id: GO:0019441
name: tryptophan catabolic process to kynurenine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including kynurenine." [GOC:go_curators]
subset: gosubset_prok
synonym: "tryptophan breakdown to kynurenine" EXACT []
synonym: "tryptophan degradation to kynurenine" EXACT []
xref: MetaCyc:TRPKYNCAT-PWY
is_a: GO:0006569 ! tryptophan catabolic process
is_a: GO:0070189 ! kynurenine metabolic process

[Term]
id: GO:0019442
name: tryptophan catabolic process to acetyl-CoA
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including acetyl-CoA." [GOC:go_curators]
subset: gosubset_prok
synonym: "tryptophan breakdown to acetyl-CoA" EXACT []
synonym: "tryptophan degradation to acetyl-CoA" EXACT []
xref: MetaCyc:TRYPTOPHAN-DEGRADATION-1
is_a: GO:0006084 ! acetyl-CoA metabolic process
is_a: GO:0006569 ! tryptophan catabolic process

[Term]
id: GO:0019443
name: obsolete tryptophan catabolic process, using tryptophanase
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of tryptophan, catalyzed by the enzyme tryptophanase (EC:4.1.99.1)." [GOC:jl]
comment: This term was made obsolete because it refers to a one-step pathway.
synonym: "tryptophan breakdown, using tryptophanase" EXACT []
synonym: "tryptophan catabolic process, using tryptophanase" EXACT []
synonym: "tryptophan degradation, using tryptophanase" EXACT []
is_obsolete: true
consider: GO:0006569
consider: GO:0009034

[Term]
id: GO:0019444
name: tryptophan catabolic process to catechol
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including catechol." [GOC:go_curators]
subset: gosubset_prok
synonym: "tryptophan breakdown to catechol" EXACT []
synonym: "tryptophan degradation to catechol" EXACT []
xref: MetaCyc:TRPCAT-PWY
is_a: GO:0006569 ! tryptophan catabolic process
is_a: GO:0009712 ! catechol-containing compound metabolic process

[Term]
id: GO:0019445
name: tyrosine catabolic process to fumarate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tyrosine into other compounds, including fumarate." [GOC:go_curators]
subset: gosubset_prok
synonym: "tyrosine breakdown to fumarate" EXACT []
synonym: "tyrosine degradation to fumarate" EXACT []
xref: MetaCyc:TYRFUMCAT-PWY
is_a: GO:0006106 ! fumarate metabolic process
is_a: GO:0006572 ! tyrosine catabolic process
is_a: GO:0043650 ! dicarboxylic acid biosynthetic process

[Term]
id: GO:0019446
name: tyrosine catabolic process to phosphoenolpyruvate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tyrosine into other compounds, including phosphoenolpyruvate." [GOC:go_curators]
subset: gosubset_prok
synonym: "tyrosine breakdown to phosphoenolpyruvate" EXACT []
synonym: "tyrosine degradation to phosphoenolpyruvate" EXACT []
is_a: GO:0006572 ! tyrosine catabolic process
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0019447
name: D-cysteine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-cysteine, (S)-2-amino-3-mercaptopropanoic acid, which occurs naturally in firefly luciferin." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "D-cysteine breakdown" EXACT []
synonym: "D-cysteine catabolism" EXACT []
synonym: "D-cysteine degradation" EXACT []
is_a: GO:0009093 ! cysteine catabolic process
is_a: GO:0019478 ! D-amino acid catabolic process
is_a: GO:0046438 ! D-cysteine metabolic process

[Term]
id: GO:0019448
name: L-cysteine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-cysteine, the L-enantiomer of 2-amino-3-mercaptopropanoic acid, i.e. (2R)-2-amino-3-mercaptopropanoic acid." [CHEBI:17561, GOC:go_curators, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "L-cysteine breakdown" EXACT []
synonym: "L-cysteine catabolism" EXACT []
synonym: "L-cysteine degradation" EXACT []
xref: Reactome:REACT_115785 "Cysteine is oxidized, Homo sapiens"
is_a: GO:0009093 ! cysteine catabolic process
is_a: GO:0046439 ! L-cysteine metabolic process

[Term]
id: GO:0019449
name: L-cysteine catabolic process to hypotaurine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-cysteine into other compounds, including hypotaurine." [GOC:go_curators]
subset: gosubset_prok
synonym: "L-cysteine breakdown to hypotaurine" EXACT []
synonym: "L-cysteine degradation to hypotaurine" EXACT []
is_a: GO:0019448 ! L-cysteine catabolic process

[Term]
id: GO:0019450
name: L-cysteine catabolic process to pyruvate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-cysteine into other compounds, including pyruvate." [GOC:go_curators]
subset: gosubset_prok
synonym: "L-cysteine breakdown to pyruvate" EXACT []
synonym: "L-cysteine degradation to pyruvate" EXACT []
xref: MetaCyc:LCYSDEG-PWY
is_a: GO:0006090 ! pyruvate metabolic process
is_a: GO:0019448 ! L-cysteine catabolic process

[Term]
id: GO:0019451
name: L-cysteine catabolic process to pyruvate, using cysteine dioxygenase
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown into pyruvate of L-cystine, catalyzed by the enzyme cysteine dioxygenase (EC:1.13.11.20)." [GOC:jl]
subset: gosubset_prok
synonym: "L-cysteine breakdown to pyruvate, using cysteine dioxygenase" EXACT []
synonym: "L-cysteine degradation to pyruvate, using cysteine dioxygenase" EXACT []
xref: MetaCyc:CYSTEINE-DEG-PWY
is_a: GO:0019450 ! L-cysteine catabolic process to pyruvate

[Term]
id: GO:0019452
name: L-cysteine catabolic process to taurine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-cysteine into other compounds, including taurine." [GOC:go_curators]
subset: gosubset_prok
synonym: "L-cysteine breakdown to taurine" EXACT []
synonym: "L-cysteine degradation to taurine" EXACT []
is_a: GO:0019448 ! L-cysteine catabolic process
is_a: GO:0019530 ! taurine metabolic process

[Term]
id: GO:0019453
name: L-cysteine catabolic process via cystine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-cysteine, via the intermediate cystine." [GOC:go_curators]
subset: gosubset_prok
synonym: "L-cysteine breakdown via cystine" EXACT []
synonym: "L-cysteine degradation via cystine" EXACT []
is_a: GO:0019448 ! L-cysteine catabolic process

[Term]
id: GO:0019454
name: L-cysteine catabolic process via cystine, using glutathione-cystine transhydrogenase
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown, via the compound cystine, of L-cysteine, catalyzed by the enzyme glutathione-cystine transhydrogenase (EC:1.8.4.4)." [GOC:jl]
subset: gosubset_prok
synonym: "L-cysteine breakdown via cystine, using glutathione-cystine transhydrogenase" EXACT []
synonym: "L-cysteine degradation via cystine, using glutathione-cystine transhydrogenase" EXACT []
is_a: GO:0019453 ! L-cysteine catabolic process via cystine

[Term]
id: GO:0019455
name: L-cysteine catabolic process via cystine, using cystine reductase
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown, via the compound cystine, of L-cysteine, catalyzed by the enzyme cystine reductase (EC:1.8.1.6)." [GOC:jl]
subset: gosubset_prok
synonym: "L-cysteine breakdown via cystine, using cystine reductase" EXACT []
synonym: "L-cysteine degradation via cystine, using cystine reductase" EXACT []
is_a: GO:0019453 ! L-cysteine catabolic process via cystine

[Term]
id: GO:0019456
name: L-cysteine catabolic process via cystine, using cysteine transaminase
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown, via the compound cystine, of L-cysteine, catalyzed by the enzyme cysteine transaminase (EC:2.6.1.3)." [GOC:jl]
subset: gosubset_prok
synonym: "L-cysteine breakdown via cystine, using cysteine transaminase" EXACT []
synonym: "L-cysteine degradation via cystine, using cysteine transaminase" EXACT []
is_a: GO:0019453 ! L-cysteine catabolic process via cystine

[Term]
id: GO:0019457
name: methionine catabolic process to succinyl-CoA
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of methionine into other compounds, including succinyl-CoA." [GOC:go_curators]
subset: gosubset_prok
synonym: "methionine breakdown to succinyl-CoA" EXACT []
synonym: "methionine degradation to succinyl-CoA" EXACT []
xref: MetaCyc:METHIONINE-DEG1-PWY
is_a: GO:0006104 ! succinyl-CoA metabolic process
is_a: GO:0009087 ! methionine catabolic process

[Term]
id: GO:0019458
name: methionine catabolic process via 2-oxobutanoate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of methionine, via the intermediate 2-oxobutanoate." [GOC:go_curators]
subset: gosubset_prok
synonym: "methionine breakdown via 2-oxobutanoate" EXACT []
synonym: "methionine degradation via 2-oxobutanoate" EXACT []
xref: MetaCyc:PWY-701
is_a: GO:0009087 ! methionine catabolic process

[Term]
id: GO:0019460
name: glutamine catabolic process to fumarate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glutamine into other compounds, including fumarate." [GOC:go_curators]
subset: gosubset_prok
synonym: "glutamate catabolic process to fumarate" NARROW [GOC:bf, GOC:jl]
synonym: "glutamine breakdown to fumarate" EXACT []
synonym: "glutamine degradation to fumarate" EXACT []
is_a: GO:0006106 ! fumarate metabolic process
is_a: GO:0006531 ! aspartate metabolic process
is_a: GO:0006538 ! glutamate catabolic process
is_a: GO:0006543 ! glutamine catabolic process
relationship: has_part GO:0019550 ! glutamate catabolic process to aspartate

[Term]
id: GO:0019461
name: glutamine catabolic process to fumarate, using glutamate synthase (NADPH)
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glutamine into fumarate, beginning with the conversion of glutamine to glutamate catalyzed by the enzyme glutamate synthase (NADPH) (EC:1.4.1.13)." [GOC:bf, GOC:jl]
subset: gosubset_prok
synonym: "glutamate catabolic process to fumarate, using glutamate synthase (NADPH)" RELATED [GOC:bf, GOC:jl]
synonym: "glutamine breakdown to fumarate, using glutamate synthase (NADPH)" EXACT []
synonym: "glutamine degradation to fumarate, using glutamate synthase (NADPH)" EXACT []
xref: MetaCyc:GLUTAMINEFUM-PWY
is_a: GO:0019460 ! glutamine catabolic process to fumarate
relationship: has_part GO:0004355 ! glutamate synthase (NADPH) activity

[Term]
id: GO:0019462
name: glutamine catabolic process to fumarate, using glutaminase
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glutamine into fumarate, beginning with conversion of glutamine into glutamate catalyzed by the enzyme glutaminase (EC:3.5.1.2)." [GOC:bf, GOC:jl]
subset: gosubset_prok
synonym: "glutamate catabolic process to fumarate, using glutaminase" RELATED [GOC:bf, GOC:jl]
synonym: "glutamine breakdown to fumarate, using glutaminase" EXACT []
synonym: "glutamine degradation to fumarate, using glutaminase" NARROW []
xref: MetaCyc:GLUTAMINDEG-PWY
is_a: GO:0019460 ! glutamine catabolic process to fumarate
relationship: has_part GO:0004359 ! glutaminase activity

[Term]
id: GO:0019463
name: glycine catabolic process to creatine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycine into other compounds, including creatine." [GOC:go_curators]
subset: gosubset_prok
synonym: "glycine breakdown to creatine" EXACT []
synonym: "glycine degradation to creatine" EXACT []
xref: MetaCyc:GLYCGREAT-PWY
is_a: GO:0006546 ! glycine catabolic process
is_a: GO:0006600 ! creatine metabolic process

[Term]
id: GO:0019464
name: glycine decarboxylation via glycine cleavage system
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycine by oxidative cleavage to carbon dioxide, ammonia, and a methylene group, mediated by enzymes of the glycine cleavage complex." [MetaCyc:GLYCLEAV-PWY]
subset: gosubset_prok
synonym: "glycine cleavage system" BROAD []
xref: MetaCyc:GLYCLEAV-PWY
is_a: GO:0006546 ! glycine catabolic process

[Term]
id: GO:0019465
name: aspartate transamidation
namespace: biological_process
def: "The exchange of the amino group of aspartate, the anion derived from aspartic acid, for another amino group." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
xref: MetaCyc:ASPARTATE-DEG1-PWY
xref: MetaCyc:ASPARTATESYN-PWY
is_a: GO:0006533 ! aspartate catabolic process

[Term]
id: GO:0019466
name: ornithine catabolic process via proline
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ornithine, via the intermediate proline." [GOC:go_curators]
subset: gosubset_prok
synonym: "ornithine breakdown via proline" EXACT []
synonym: "ornithine degradation via proline" EXACT []
xref: MetaCyc:ORN-AMINOPENTANOATE-CAT-PWY
is_a: GO:0006560 ! proline metabolic process
is_a: GO:0006593 ! ornithine catabolic process

[Term]
id: GO:0019467
name: ornithine catabolic process, by decarboxylation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ornithine by decarboxylation." [GOC:go_curators]
subset: gosubset_prok
synonym: "ornithine breakdown, by decarboxylation" EXACT []
synonym: "ornithine degradation, by decarboxylation" EXACT []
xref: MetaCyc:ORNDEG-PWY
is_a: GO:0006593 ! ornithine catabolic process

[Term]
id: GO:0019468
name: nopaline catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of nopaline (N-(I-carboxy-4-guanidinobutyl)glutamic acid), a rare amino-acid derivative." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "nopaline breakdown" EXACT []
synonym: "nopaline catabolism" EXACT []
synonym: "nopaline degradation" EXACT []
xref: MetaCyc:NOPALINEDEG-PWY
is_a: GO:0042219 ! cellular modified amino acid catabolic process
is_a: GO:0046418 ! nopaline metabolic process
is_a: GO:0072352 ! tricarboxylic acid catabolic process
is_a: GO:1901606 ! alpha-amino acid catabolic process

[Term]
id: GO:0019469
name: octopine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of octopine (N-(1-carboxy-4-guanidinobutyl)-L-alanine), an amino acid derived opine." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "octopine breakdown" EXACT []
synonym: "octopine catabolism" EXACT []
synonym: "octopine degradation" EXACT []
xref: MetaCyc:OCTOPINEDEG-PWY
is_a: GO:0019478 ! D-amino acid catabolic process
is_a: GO:0042219 ! cellular modified amino acid catabolic process
is_a: GO:0043649 ! dicarboxylic acid catabolic process
is_a: GO:0046419 ! octopine metabolic process

[Term]
id: GO:0019470
name: 4-hydroxyproline catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline." [GOC:ai]
subset: gosubset_prok
synonym: "4-hydroxyproline breakdown" EXACT []
synonym: "4-hydroxyproline catabolism" EXACT []
synonym: "4-hydroxyproline degradation" EXACT []
xref: MetaCyc:HYDROXYPRODEG-PWY
is_a: GO:0019471 ! 4-hydroxyproline metabolic process
is_a: GO:0042219 ! cellular modified amino acid catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901606 ! alpha-amino acid catabolic process

[Term]
id: GO:0019471
name: 4-hydroxyproline metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline. The presence of hydroxyproline is essential to produce stable triple helical tropocollagen, hence the problems caused by ascorbate deficiency in scurvy. This unusual amino acid is also present in considerable amounts in the major glycoprotein of primary plant cell walls." [CHEBI:20392, GOC:ai]
subset: gosubset_prok
synonym: "4-hydroxyproline metabolism" EXACT []
is_a: GO:0006575 ! cellular modified amino acid metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901605 ! alpha-amino acid metabolic process

[Term]
id: GO:0019472
name: 4-hydroxyproline biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline." [GOC:ai]
subset: gosubset_prok
synonym: "4-hydroxyproline anabolism" EXACT []
synonym: "4-hydroxyproline biosynthesis" EXACT []
synonym: "4-hydroxyproline formation" EXACT []
synonym: "4-hydroxyproline synthesis" EXACT []
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0019471 ! 4-hydroxyproline metabolic process
is_a: GO:0042398 ! cellular modified amino acid biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901607 ! alpha-amino acid biosynthetic process

[Term]
id: GO:0019473
name: L-lysine catabolic process to glutarate, by acetylation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including glutarate, by acetylation." [GOC:go_curators]
subset: gosubset_prok
synonym: "L-lysine breakdown to glutarate, by acetylation" EXACT []
synonym: "L-lysine degradation to glutarate, by acetylation" EXACT []
xref: MetaCyc:LYSDEGII-PWY
is_a: GO:0019477 ! L-lysine catabolic process

[Term]
id: GO:0019474
name: L-lysine catabolic process to acetyl-CoA
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA." [GOC:go_curators]
subset: gosubset_prok
synonym: "L-lysine breakdown to acetyl-CoA" EXACT []
synonym: "L-lysine degradation to acetyl-CoA" EXACT []
is_a: GO:0006084 ! acetyl-CoA metabolic process
is_a: GO:0019477 ! L-lysine catabolic process

[Term]
id: GO:0019475
name: L-lysine catabolic process to acetate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetate." [GOC:go_curators]
subset: gosubset_prok
synonym: "L-lysine breakdown to acetate" EXACT []
synonym: "L-lysine degradation to acetate" EXACT []
synonym: "lysine fermentation" EXACT []
xref: MetaCyc:P163-PWY
is_a: GO:0006083 ! acetate metabolic process
is_a: GO:0019477 ! L-lysine catabolic process
is_a: GO:0019665 ! anaerobic amino acid catabolic process

[Term]
id: GO:0019476
name: D-lysine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-lysine, the D-enantiomer of lysine; i.e. (2R)-2,6-diaminohexanoic acid." [CHEBI:16855, GOC:ai, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "D-lysine breakdown" EXACT []
synonym: "D-lysine catabolism" EXACT []
synonym: "D-lysine degradation" EXACT []
is_a: GO:0006554 ! lysine catabolic process
is_a: GO:0019478 ! D-amino acid catabolic process
is_a: GO:0046441 ! D-lysine metabolic process

[Term]
id: GO:0019477
name: L-lysine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-lysine, the L-enantiomer of (S)-2,6-diaminohexanoic acid." [GOC:go_curators, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "L-lysine breakdown" EXACT []
synonym: "L-lysine catabolism" EXACT []
synonym: "L-lysine degradation" EXACT []
is_a: GO:0006554 ! lysine catabolic process
is_a: GO:0046440 ! L-lysine metabolic process

[Term]
id: GO:0019478
name: D-amino acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-amino acids, the D-enantiomers of amino acids." [GOC:ai, GOC:jsg]
subset: gosubset_prok
synonym: "D-amino acid breakdown" EXACT []
synonym: "D-amino acid catabolism" EXACT []
synonym: "D-amino acid degradation" EXACT []
is_a: GO:0046416 ! D-amino acid metabolic process
is_a: GO:1901606 ! alpha-amino acid catabolic process

[Term]
id: GO:0019479
name: L-alanine oxidation to D-lactate and ammonia
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-alanine to D-lactate and ammonia." [MetaCyc:ALACAT2-PWY]
subset: gosubset_prok
xref: MetaCyc:ALACAT2-PWY
is_a: GO:0042853 ! L-alanine catabolic process
is_a: GO:0055114 ! oxidation-reduction process

[Term]
id: GO:0019480
name: L-alanine oxidation to pyruvate via D-alanine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-alanine to pyruvate, with D-alanine as an intermediate." [MetaCyc:ALADEG-PWY]
subset: gosubset_prok
xref: MetaCyc:ALADEG-PWY
is_a: GO:0042853 ! L-alanine catabolic process
is_a: GO:0055114 ! oxidation-reduction process

[Term]
id: GO:0019481
name: L-alanine catabolic process, by transamination
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-alanine by transamination." [GOC:go_curators]
subset: gosubset_prok
synonym: "L-alanine breakdown, by transamination" EXACT []
synonym: "L-alanine degradation, by transamination" EXACT []
xref: MetaCyc:ALANINE-DEG3-PWY
is_a: GO:0042853 ! L-alanine catabolic process

[Term]
id: GO:0019482
name: beta-alanine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "beta-alanine metabolism" EXACT []
xref: Wikipedia:Beta-alanine
is_a: GO:0006520 ! cellular amino acid metabolic process

[Term]
id: GO:0019483
name: beta-alanine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "beta-alanine anabolism" EXACT []
synonym: "beta-alanine biosynthesis" EXACT []
synonym: "beta-alanine formation" EXACT []
synonym: "beta-alanine synthesis" EXACT []
is_a: GO:0008652 ! cellular amino acid biosynthetic process
is_a: GO:0019482 ! beta-alanine metabolic process

[Term]
id: GO:0019484
name: beta-alanine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "beta-alanine breakdown" EXACT []
synonym: "beta-alanine catabolism" EXACT []
synonym: "beta-alanine degradation" EXACT []
is_a: GO:0009063 ! cellular amino acid catabolic process
is_a: GO:0019482 ! beta-alanine metabolic process

[Term]
id: GO:0019485
name: beta-alanine catabolic process to L-alanine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of beta-alanine into other compounds, including L-alanine." [GOC:go_curators]
subset: gosubset_prok
synonym: "beta-alanine breakdown to L-alanine" EXACT []
synonym: "beta-alanine degradation to L-alanine" EXACT []
is_a: GO:0019484 ! beta-alanine catabolic process
is_a: GO:0042851 ! L-alanine metabolic process

[Term]
id: GO:0019486
name: beta-alanine catabolic process to mevalonate semialdehyde, by transamination
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of beta-alanine into other compounds, including mevalonate semialdehyde, by transamination." [GOC:go_curators]
subset: gosubset_prok
synonym: "beta-alanine breakdown to mevalonate semialdehyde, by transamination" EXACT []
synonym: "beta-alanine degradation to mevalonate semialdehyde, by transamination" EXACT []
xref: MetaCyc:BETA-ALA-DEGRADATION-I-PWY
is_a: GO:0019484 ! beta-alanine catabolic process

[Term]
id: GO:0019487
name: anaerobic acetylene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving acetylene, a colorless, volatile, explosive gas, that occur in the absence of oxygen." [ISBN:0721662544]
subset: gosubset_prok
synonym: "anaerobic acetylene breakdown" EXACT []
synonym: "anaerobic acetylene catabolism" EXACT []
synonym: "anaerobic acetylene degradation" EXACT []
synonym: "anaerobic ethyne catabolic process" EXACT []
synonym: "anaerobic ethyne catabolism" EXACT []
xref: MetaCyc:P161-PWY
is_a: GO:0018864 ! acetylene metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0043454 ! alkyne catabolic process

[Term]
id: GO:0019488
name: ribitol catabolic process to xylulose 5-phosphate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ribitol to form xylulose 5-phosphate. Ribitol is initially converted to D-ribulose, which is phosphorylated to form ribulose 5-phosphate, which is then converted into xylulose 5-phosphate." [MetaCyc:RIBITOLUTIL-PWY]
subset: gosubset_prok
synonym: "ribitol breakdown to xylulose 5-phosphate" EXACT []
synonym: "ribitol degradation to xylulose 5-phosphate" EXACT []
synonym: "ribitol utilization" RELATED []
xref: MetaCyc:RIBITOLUTIL-PWY
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:0046363 ! ribitol catabolic process
is_a: GO:1901159 ! xylulose 5-phosphate biosynthetic process

[Term]
id: GO:0019489
name: methylgallate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving methylgallate, trihydroxymethylbenzoate, the anion of methylgallic acid." [GOC:ai]
subset: gosubset_prok
synonym: "methylgallate metabolism" EXACT []
is_a: GO:0009712 ! catechol-containing compound metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:0019490
name: 2-aminobenzenesulfonate desulfonation
namespace: biological_process
def: "The removal of the sulfonate group from 2-aminobenzenesulfonate, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines." [UM-BBD_pathwayID:abs]
subset: gosubset_prok
synonym: "2-aminobenzenesulphonate desulphonation" EXACT []
xref: MetaCyc:2ASDEG-PWY
is_a: GO:0018868 ! 2-aminobenzenesulfonate metabolic process

[Term]
id: GO:0019491
name: ectoine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid), a tetrahydropyrimidine commonly synthesized by halophilic bacteria." [GOC:jl, PMID:11823218]
subset: gosubset_prok
synonym: "ectoine anabolism" EXACT []
synonym: "ectoine biosynthesis" EXACT []
synonym: "ectoine formation" EXACT []
synonym: "ectoine synthesis" EXACT []
xref: MetaCyc:P101-PWY
is_a: GO:0042399 ! ectoine metabolic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:0072528 ! pyrimidine-containing compound biosynthetic process

[Term]
id: GO:0019492
name: proline salvage
namespace: biological_process
def: "Any process which produces the amino acid proline from derivatives of it, without de novo synthesis." [GOC:jl]
subset: gosubset_prok
synonym: "proline cycling" EXACT []
is_a: GO:0006561 ! proline biosynthetic process
is_a: GO:0043102 ! amino acid salvage

[Term]
id: GO:0019493
name: arginine catabolic process to proline
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including proline." [GOC:go_curators]
subset: gosubset_prok
synonym: "arginine breakdown to proline" EXACT []
synonym: "arginine degradation to proline" EXACT []
xref: MetaCyc:ARG-PRO-PWY
is_a: GO:0006527 ! arginine catabolic process
is_a: GO:0006560 ! proline metabolic process

[Term]
id: GO:0019495
name: proline catabolic process to 2-oxoglutarate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of proline into other compounds, including 2-oxoglutarate." [GOC:go_curators]
subset: gosubset_prok
synonym: "proline breakdown to 2-oxoglutarate" EXACT []
synonym: "proline catabolic process to 2-ketoglutarate" EXACT []
synonym: "proline catabolic process to alpha-ketoglutarate" EXACT []
synonym: "proline catabolic process to alpha-oxoglutarate" EXACT []
synonym: "proline catabolism to 2-ketoglutarate" EXACT []
synonym: "proline catabolism to alpha-ketoglutarate" EXACT []
synonym: "proline catabolism to alpha-oxoglutarate" EXACT []
synonym: "proline degradation to 2-oxoglutarate" EXACT []
is_a: GO:0006103 ! 2-oxoglutarate metabolic process
is_a: GO:0006562 ! proline catabolic process

[Term]
id: GO:0019496
name: serine-isocitrate lyase pathway
namespace: biological_process
def: "A one-carbon metabolic process in which acetyl-CoA is produced from formaldehyde and carbon dioxide." [ISBN:0387961534]
subset: gosubset_prok
is_a: GO:0006730 ! one-carbon metabolic process

[Term]
id: GO:0019497
name: hexachlorocyclohexane metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving hexachlorocyclohexane, a cyclohexane derivative with 6 chlorine atoms attached to the hexane ring. Hexachlorocyclohexane consists of a mixture of 8 different isomers and was used a commercial insecticide. It is persistent in the environment, causing serious soil pollution." [UM-BBD_pathwayID:ghch, UM-BBD_pathwayID:hch]
subset: gosubset_prok
synonym: "hexachlorocyclohexane metabolism" EXACT []
is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process

[Term]
id: GO:0019498
name: n-octane oxidation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the conversion of n-octane to octanoyl-CoA." [MetaCyc:P221-PWY]
subset: gosubset_prok
xref: MetaCyc:P221-PWY
is_a: GO:0018939 ! n-octane metabolic process
is_a: GO:0055114 ! oxidation-reduction process

[Term]
id: GO:0019499
name: cyanide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cyanide, NC-, the anion of hydrocyanic acid. Cyanide is a potent inhibitor of respiration, reacting with the ferric form of cytochrome aa3 and thus blocking the electron transport chain." [ISBN:0198506732]
subset: gosubset_prok
synonym: "cyanide metabolism" EXACT []
is_a: GO:0034641 ! cellular nitrogen compound metabolic process
is_a: GO:0044710 ! single-organism metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0071704 ! organic substance metabolic process

[Term]
id: GO:0019500
name: cyanide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cyanide, NC-, the anion of hydrocyanic acid. Cyanide is a potent inhibitor of respiration." [ISBN:0198506732]
subset: gosubset_prok
synonym: "cyanide breakdown" EXACT []
synonym: "cyanide catabolism" EXACT []
synonym: "cyanide degradation" EXACT []
xref: MetaCyc:P401-PWY
is_a: GO:0019499 ! cyanide metabolic process
is_a: GO:0044270 ! cellular nitrogen compound catabolic process
is_a: GO:0044712 ! single-organism catabolic process
is_a: GO:1901575 ! organic substance catabolic process

[Term]
id: GO:0019501
name: arsonoacetate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of arsonoacetate, a synthetic, organic compound containing a single arsenic atom." [GOC:jl]
subset: gosubset_prok
synonym: "arsonoacetate breakdown" EXACT []
synonym: "arsonoacetate catabolism" EXACT []
synonym: "arsonoacetate degradation" EXACT []
xref: MetaCyc:P482-PWY
is_a: GO:0018872 ! arsonoacetate metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0019502
name: stachydrine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving stachydrine, N-methylproline methylbetaine, the betaine derivative of L-proline found in alfalfa, chrysanthemum, and citrus plants." [GOC:curators, MetaCyc:CPD-821]
subset: gosubset_prok
synonym: "stachydrine metabolism" EXACT []
is_a: GO:0006575 ! cellular modified amino acid metabolic process
is_a: GO:0006577 ! amino-acid betaine metabolic process
is_a: GO:0009820 ! alkaloid metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:0097164 ! ammonium ion metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901605 ! alpha-amino acid metabolic process

[Term]
id: GO:0019503
name: stachydrine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of stachydrine, N-methylproline methylbetaine, the betaine derivative of L-proline." [GOC:ai]
subset: gosubset_prok
synonym: "stachydrine anabolism" EXACT []
synonym: "stachydrine biosynthesis" EXACT []
synonym: "stachydrine formation" EXACT []
synonym: "stachydrine synthesis" EXACT []
is_a: GO:0006578 ! amino-acid betaine biosynthetic process
is_a: GO:0009821 ! alkaloid biosynthetic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0019502 ! stachydrine metabolic process
is_a: GO:0042398 ! cellular modified amino acid biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901607 ! alpha-amino acid biosynthetic process

[Term]
id: GO:0019504
name: stachydrine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of stachydrine, N-methylproline methylbetaine, the betaine derivative of L-proline." [GOC:ai]
subset: gosubset_prok
synonym: "stachydrine breakdown" EXACT []
synonym: "stachydrine catabolism" EXACT []
synonym: "stachydrine degradation" EXACT []
xref: MetaCyc:P561-PWY
is_a: GO:0006579 ! amino-acid betaine catabolic process
is_a: GO:0009822 ! alkaloid catabolic process
is_a: GO:0019502 ! stachydrine metabolic process
is_a: GO:0042219 ! cellular modified amino acid catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901606 ! alpha-amino acid catabolic process

[Term]
id: GO:0019505
name: resorcinol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving resorcinol (C6H4(OH)2), a benzene derivative with many applications, including dyes, explosives, resins and as an antiseptic." [GOC:jl, http://www.speclab.com/compound/c108463.htm]
subset: gosubset_prok
synonym: "1,3-benzenediol metabolic process" EXACT []
synonym: "1,3-benzenediol metabolism" EXACT []
synonym: "1,3-dihydroxybenzene metabolic process" EXACT []
synonym: "1,3-dihydroxybenzene metabolism" EXACT []
synonym: "resorcinol metabolism" EXACT []
xref: MetaCyc:P343-PWY
is_a: GO:0018958 ! phenol-containing compound metabolic process

[Term]
id: GO:0019506
name: phenylmercury acetate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phenylmercury acetate, an organomercurial compound composed of a mercury atom attached to a benzene ring and an acetate group." [GOC:ai]
subset: gosubset_prok
synonym: "phenylmercury acetate breakdown" EXACT []
synonym: "phenylmercury acetate catabolism" EXACT []
synonym: "phenylmercury acetate degradation" EXACT []
xref: MetaCyc:P641-PWY
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0046412 ! phenylmercury acetate metabolic process
is_a: GO:0046413 ! organomercury catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process

[Term]
id: GO:0019507
name: pyridine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pyridine, a nitrogenous base (C5H5N) obtained from the distillation of bone oil or coal tar, and by the decomposition of certain alkaloids, as a colorless liquid with a peculiar pungent odor." [CHEBI:16227, GOC:curators]
subset: gosubset_prok
synonym: "pyridine metabolism" EXACT []
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0072524 ! pyridine-containing compound metabolic process

[Term]
id: GO:0019508
name: 2,5-dihydroxypyridine catabolic process to fumarate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 2,5-dihydroxypyridine to form fumarate. 2,5-dihydroxypyridine is dioxygenated to give maleamate and formate; the maleamate from this reaction is then converted to maleate, which is then isomerized to fumurate." [MetaCyc:PWY-722]
subset: gosubset_prok
synonym: "2,5-dihydroxypyridine breakdown to fumarate" EXACT []
synonym: "2,5-dihydroxypyridine degradation to fumarate" EXACT []
synonym: "2,5-dihydroxypyridine utilization" RELATED []
synonym: "maleamate pathway" EXACT []
synonym: "pyridine-2,5-diol catabolic process to fumarate" EXACT [CHEBI:16364]
xref: MetaCyc:PWY-722
is_a: GO:0006106 ! fumarate metabolic process
is_a: GO:0044712 ! single-organism catabolic process
is_a: GO:0051166 ! 2,5-dihydroxypyridine catabolic process

[Term]
id: GO:0019509
name: L-methionine biosynthetic process from methylthioadenosine
namespace: biological_process
def: "The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine." [GOC:jl, MetaCyc:PWY-4361]
subset: gosubset_prok
synonym: "L-methionine salvage from methylthioadenosine" EXACT []
synonym: "methionine recycling" NARROW []
synonym: "methionine regeneration" NARROW []
synonym: "methionine salvage from methylthioadenosine" EXACT [GOC:mah]
synonym: "methionine salvage pathway" EXACT []
xref: MetaCyc:PWY-4361
xref: Reactome:REACT_75811 "Transamination of MOB to methionine, Homo sapiens"
xref: Reactome:REACT_75828 "Dehydration of methylthio-ribulose-P, Homo sapiens"
xref: Reactome:REACT_75881 "Methionine salvage pathway, Homo sapiens"
is_a: GO:0071267 ! L-methionine salvage

[Term]
id: GO:0019510
name: S-adenosylhomocysteine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of S-adenosylhomocysteine, forming homocysteine and then methionine." [ISBN:0198506732]
subset: gosubset_prok
synonym: "S-adenosylhomocysteine breakdown" EXACT []
synonym: "S-adenosylhomocysteine catabolism" EXACT []
synonym: "S-adenosylhomocysteine degradation" EXACT []
xref: MetaCyc:ADENOSYLHOMOCYSCAT-PWY
is_a: GO:0042219 ! cellular modified amino acid catabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0046130 ! purine ribonucleoside catabolic process
is_a: GO:0046498 ! S-adenosylhomocysteine metabolic process
is_a: GO:1901606 ! alpha-amino acid catabolic process

[Term]
id: GO:0019511
name: peptidyl-proline hydroxylation
namespace: biological_process
alt_id: GO:0006472
def: "The hydroxylation of peptidyl-proline to form peptidyl-hydroxyproline." [GOC:mah]
subset: gosubset_prok
is_a: GO:0018126 ! protein hydroxylation
is_a: GO:0018208 ! peptidyl-proline modification

[Term]
id: GO:0019512
name: lactose catabolic process via tagatose-6-phosphate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lactose, via the intermediate tagatose-6-phosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "lactose breakdown via tagatose-6-phosphate" EXACT []
synonym: "lactose degradation via tagatose-6-phosphate" EXACT []
xref: MetaCyc:LACTOSECAT-PWY
is_a: GO:0005990 ! lactose catabolic process

[Term]
id: GO:0019513
name: lactose catabolic process, using glucoside 3-dehydrogenase
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lactose, catalyzed by the enzyme glucoside 3-dehydrogenase (EC:1.1.99.13)." [GOC:jl]
subset: gosubset_prok
synonym: "lactose breakdown, using glucoside 3-dehydrogenase" EXACT []
synonym: "lactose degradation, using glucoside 3-dehydrogenase" EXACT []
xref: MetaCyc:LACTOSEUTIL-PWY
is_a: GO:0005990 ! lactose catabolic process

[Term]
id: GO:0019514
name: obsolete lactose hydrolysis
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because hydrolysis is a reaction.
synonym: "lactose hydrolysis" EXACT []
is_obsolete: true
consider: GO:0004565

[Term]
id: GO:0019515
name: lactose catabolic process via UDP-galactose
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lactose, via the intermediate UDP-galactose." [GOC:go_curators]
subset: gosubset_prok
synonym: "lactose breakdown via UDP-galactose" EXACT []
synonym: "lactose degradation via UDP-galactose" EXACT []
is_a: GO:0005990 ! lactose catabolic process

[Term]
id: GO:0019516
name: lactate oxidation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the conversion of lactate to other compounds, such as pyruvate, with concomitant loss of electrons." [GOC:mah]
subset: gosubset_prok
is_a: GO:0006089 ! lactate metabolic process
is_a: GO:0055114 ! oxidation-reduction process

[Term]
id: GO:0019517
name: L-threonine catabolic process to D-lactate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L- threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) to form the compound methylglyoxal, which is subsequently converted to D-lactate." [GOC:bf, GOC:jl, MetaCyc:PWY-901, MetaCyc:THRDLCTCAT-PWY]
subset: gosubset_prok
synonym: "L-threonine breakdown to D-lactate" EXACT [GOC:bf]
synonym: "L-threonine catabolic process to (R)-lactate" BROAD [CHEBI:16004, GOC:bf]
synonym: "L-threonine catabolic process to methylglyoxal" EXACT [MetaCyc:THRDLCTCAT-PWY]
synonym: "L-threonine catabolic process to pyruvate" RELATED [GOC:bf, GOC:mah]
synonym: "L-threonine catabolism to D-lactate" EXACT [GOC:bf, GOC:mah]
synonym: "L-threonine degradation to D-lactate" EXACT [GOC:bf]
synonym: "threonine catabolic process to D-lactate" BROAD [GOC:bf]
xref: MetaCyc:THRDLCTCAT-PWY
is_a: GO:0006089 ! lactate metabolic process
is_a: GO:0006567 ! threonine catabolic process

[Term]
id: GO:0019518
name: L-threonine catabolic process to glycine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) to form to form 2-amino-3-oxobutanoate, which is subsequently converted to glycine." [GOC:bf, GOC:mah, MetaCyc:THREONINE-DEG2-PWY]
subset: gosubset_prok
synonym: "L-threonine breakdown to glycine" EXACT [GOC:bf, GOC:mah]
synonym: "L-threonine catabolic process to pyruvate" RELATED [GOC:bf, GOC:mah]
synonym: "L-threonine catabolism to glycine" EXACT [GOC:bf, GOC:mah]
synonym: "L-threonine degradation to glycine" EXACT [GOC:bf, GOC:mah]
synonym: "threonine catabolic process to glycine" BROAD [GOC:bf]
xref: MetaCyc:THREONINE-DEG2-PWY
is_a: GO:0006544 ! glycine metabolic process
is_a: GO:0006567 ! threonine catabolic process

[Term]
id: GO:0019519
name: pentitol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pentitols, any alditol with a chain of five carbon atoms in the molecule." [ISBN:0198506732]
subset: gosubset_prok
synonym: "pentitol metabolism" EXACT []
is_a: GO:0019400 ! alditol metabolic process

[Term]
id: GO:0019520
name: aldonic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aldonic acid, a monocarboxylic acid with a chain of three or more carbon atoms, derived from an aldose by oxidation of the aldehydic group." [ISBN:0198506732]
subset: gosubset_prok
synonym: "aldonic acid metabolism" EXACT []
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0044262 ! cellular carbohydrate metabolic process
is_a: GO:0044723 ! single-organism carbohydrate metabolic process

[Term]
id: GO:0019521
name: D-gluconate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-gluconate, the anion of D-gluconic acid, the aldonic acid derived from glucose." [ISBN:0198506732]
subset: gosubset_prok
synonym: "D-gluconate metabolism" EXACT []
is_a: GO:0019520 ! aldonic acid metabolic process

[Term]
id: GO:0019522
name: ketogluconate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ketogluconate, the anion of ketogluconic acid, an aldonic acid derived from glucose containing a ketonic carbonyl group." [ISBN:0198506732]
subset: gosubset_prok
synonym: "ketogluconate metabolism" EXACT []
xref: MetaCyc:KETOGLUCONMET-PWY
is_a: GO:0019520 ! aldonic acid metabolic process

[Term]
id: GO:0019523
name: L-idonate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving L-idonate, the anion of idonic acid, an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose." [CHEBI:17796, GOC:ai]
subset: gosubset_prok
synonym: "L-idonate metabolism" EXACT []
xref: MetaCyc:IDNCAT-PWY
is_a: GO:0019520 ! aldonic acid metabolic process

[Term]
id: GO:0019524
name: keto-D-gluconate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of keto-D-gluconate, the anion of keto-D-gluconic acid, an aldonic acid derived from glucose." [ISBN:0198506732]
subset: gosubset_prok
synonym: "keto-D-gluconate breakdown" EXACT []
synonym: "keto-D-gluconate catabolism" EXACT []
synonym: "keto-D-gluconate degradation" EXACT []
xref: MetaCyc:DHGLUCONATE-PYR-CAT-PWY
is_a: GO:0019525 ! keto-D-gluconate metabolic process
is_a: GO:0046181 ! ketogluconate catabolic process

[Term]
id: GO:0019525
name: keto-D-gluconate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving keto-D-gluconate, the anion of keto-D-gluconic acid, an aldonic acid derived from glucose." [ISBN:0198506732]
subset: gosubset_prok
synonym: "keto-D-gluconate metabolism" EXACT []
is_a: GO:0019522 ! ketogluconate metabolic process

[Term]
id: GO:0019526
name: pentitol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pentitols, any alditol with a chain of five carbon atoms in the molecule." [ISBN:0198506732]
subset: gosubset_prok
synonym: "pentitol anabolism" EXACT []
synonym: "pentitol biosynthesis" EXACT []
synonym: "pentitol formation" EXACT []
synonym: "pentitol synthesis" EXACT []
is_a: GO:0019401 ! alditol biosynthetic process
is_a: GO:0019519 ! pentitol metabolic process

[Term]
id: GO:0019527
name: pentitol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pentitols, any alditol with a chain of five carbon atoms in the molecule." [ISBN:0198506732]
subset: gosubset_prok
synonym: "pentitol breakdown" EXACT []
synonym: "pentitol catabolism" EXACT []
synonym: "pentitol degradation" EXACT []
is_a: GO:0019405 ! alditol catabolic process
is_a: GO:0019519 ! pentitol metabolic process

[Term]
id: GO:0019528
name: D-arabitol catabolic process to xylulose 5-phosphate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-arabitol to form xylulose 5-phosphate. D-arabitol is converted into D-xylulose, which is then phosphorylated to form D-xylulose-5-phosphate." [MetaCyc:DARABITOLUTIL-PWY]
subset: gosubset_prok
synonym: "D-arabitol breakdown to xylulose 5-phosphate" EXACT []
synonym: "D-arabitol degradation" RELATED []
synonym: "D-arabitol degradation to xylulose 5-phosphate" EXACT []
synonym: "D-arabitol utilization" RELATED []
xref: MetaCyc:DARABITOLUTIL-PWY
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:0051159 ! D-arabitol catabolic process
is_a: GO:1901159 ! xylulose 5-phosphate biosynthetic process

[Term]
id: GO:0019529
name: taurine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of taurine (2-aminoethanesulfonic acid), a sulphur-containing amino acid derivative important in the metabolism of fats." [GOC:jl, ISBN:0198600461]
subset: gosubset_prok
synonym: "taurine breakdown" EXACT []
synonym: "taurine catabolism" EXACT []
synonym: "taurine degradation" EXACT []
xref: MetaCyc:TAURINEDEG-PWY
is_a: GO:0019530 ! taurine metabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process

[Term]
id: GO:0019530
name: taurine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving taurine (2-aminoethanesulfonic acid), a sulphur-containing amino acid derivative important in the metabolism of fats." [GOC:jl, ISBN:0198600461]
subset: gosubset_prok
synonym: "taurine metabolism" EXACT []
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process

[Term]
id: GO:0019531
name: oxalate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of oxalate from one side of the membrane to the other. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals." [ISBN:0198506732]
subset: gosubset_prok
synonym: "oxalic acid transporter activity" EXACT []
is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity
relationship: part_of GO:0019532 ! oxalate transport

[Term]
id: GO:0019532
name: oxalate transport
namespace: biological_process
def: "The directed movement of oxalate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals." [ISBN:0198506732]
subset: gosubset_prok
synonym: "ethanedioate transport" EXACT []
synonym: "ethanedioic acid transport" EXACT []
synonym: "oxalic acid transport" EXACT []
is_a: GO:0006835 ! dicarboxylic acid transport

[Term]
id: GO:0019533
name: cellobiose transport
namespace: biological_process
def: "The directed movement of cellobiose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Cellobiose, or 4-O-beta-D-glucopyranosyl-D-glucose, is a disaccharide that represents the basic repeating unit of cellulose." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015766 ! disaccharide transport

[Term]
id: GO:0019534
name: toxin transporter activity
namespace: molecular_function
def: "Enables the directed movement of a toxin into, out of or within a cell, or between cells. A toxin is a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism." [ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0005215 ! transporter activity
relationship: part_of GO:1901998 ! toxin transport

[Term]
id: GO:0019535
name: ferric-vibriobactin transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of ferric-vibriobactin ions from one side of a membrane to the other." [GOC:ai]
is_a: GO:0015343 ! siderophore transmembrane transporter activity

[Term]
id: GO:0019536
name: vibriobactin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving vibriobactin, the major siderophore produced by Vibrio cholerae." [GOC:jl, PMID:11112537]
subset: gosubset_prok
synonym: "vibriobactin metabolism" EXACT []
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0009237 ! siderophore metabolic process
is_a: GO:0043603 ! cellular amide metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process

[Term]
id: GO:0019537
name: vibriobactin biosynthetic process
namespace: biological_process
alt_id: GO:0031195
alt_id: GO:0031196
def: "The chemical reactions and pathways resulting in the formation of vibriobactin, the major siderophore produced by Vibrio cholerae." [GOC:jl, PMID:11112537]
subset: gosubset_prok
synonym: "vibriobactin anabolism" EXACT []
synonym: "vibriobactin biosynthesis" EXACT []
synonym: "vibriobactin biosynthetic process, peptide formation" NARROW []
synonym: "vibriobactin biosynthetic process, peptide modification" NARROW []
synonym: "vibriobactin formation" EXACT []
synonym: "vibriobactin synthesis" EXACT []
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0019536 ! vibriobactin metabolic process
is_a: GO:0043604 ! amide biosynthetic process
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process

[Term]
id: GO:0019538
name: protein metabolic process
namespace: biological_process
alt_id: GO:0006411
def: "The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification." [GOC:ma]
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "protein metabolic process and modification" EXACT []
synonym: "protein metabolism" EXACT []
synonym: "protein metabolism and modification" EXACT []
xref: Wikipedia:Protein_metabolism
is_a: GO:0043170 ! macromolecule metabolic process
is_a: GO:0044238 ! primary metabolic process

[Term]
id: GO:0019539
name: siderophore biosynthetic process from hydroxamic acid
namespace: biological_process
alt_id: GO:0031197
alt_id: GO:0031198
def: "The chemical reactions and pathways resulting in the formation of a siderophore from other compounds, including hydroxamic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "siderochrome biosynthesis from hydroxamic acid" NARROW []
synonym: "siderochrome biosynthetic process from hydroxamic acid" NARROW []
synonym: "siderophore anabolism from hydroxamic acid" EXACT []
synonym: "siderophore biosynthetic process from hydroxamic acid, peptide formation" NARROW []
synonym: "siderophore biosynthetic process from hydroxamic acid, peptide modification" NARROW []
synonym: "siderophore formation from hydroxamic acid" EXACT []
synonym: "siderophore synthesis from hydroxamic acid" EXACT []
is_a: GO:0019290 ! siderophore biosynthetic process

[Term]
id: GO:0019540
name: siderophore biosynthetic process from catechol
namespace: biological_process
alt_id: GO:0031189
alt_id: GO:0031190
def: "The chemical reactions and pathways resulting in the formation of a siderophore from other compounds, including catechol." [GOC:go_curators]
subset: gosubset_prok
synonym: "siderochrome biosynthesis from catechol" NARROW []
synonym: "siderochrome biosynthetic process from catechol" NARROW []
synonym: "siderophore anabolism from catechol" EXACT []
synonym: "siderophore biosynthetic process from catechol, peptide formation" NARROW []
synonym: "siderophore biosynthetic process from catechol, peptide modification" NARROW []
synonym: "siderophore formation from catechol" EXACT []
synonym: "siderophore synthesis from catechol" EXACT []
is_a: GO:0009712 ! catechol-containing compound metabolic process
is_a: GO:0019290 ! siderophore biosynthetic process

[Term]
id: GO:0019541
name: propionate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving propionate, the anion derived from propionic (propanoic) acid, a carboxylic acid important in the energy metabolism of ruminants." [GOC:go_curators, ISBN:0198506732, KEGG:C00163, MetaCyc:PROPIONATE]
subset: gosubset_prok
synonym: "propanoate metabolic process" EXACT []
synonym: "propanoate metabolism" EXACT []
synonym: "propionate metabolism" EXACT []
is_a: GO:0046459 ! short-chain fatty acid metabolic process

[Term]
id: GO:0019542
name: propionate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of propionate, the anion derived from propionic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "propionate anabolism" EXACT []
synonym: "propionate biosynthesis" EXACT []
synonym: "propionate formation" EXACT []
synonym: "propionate synthesis" EXACT []
is_a: GO:0019541 ! propionate metabolic process
is_a: GO:0051790 ! short-chain fatty acid biosynthetic process

[Term]
id: GO:0019543
name: propionate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of propionate, the anion derived from propionic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "propionate breakdown" EXACT []
synonym: "propionate catabolism" EXACT []
synonym: "propionate degradation" EXACT []
is_a: GO:0019541 ! propionate metabolic process
is_a: GO:0019626 ! short-chain fatty acid catabolic process

[Term]
id: GO:0019544
name: arginine catabolic process to glutamate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including glutamate." [GOC:go_curators]
subset: gosubset_prok
synonym: "arginine breakdown to glutamate" EXACT []
synonym: "arginine degradation to glutamate" EXACT []
xref: MetaCyc:ARG-GLU-PWY
xref: MetaCyc:ARGASEDEG-PWY
is_a: GO:0006527 ! arginine catabolic process
is_a: GO:0006536 ! glutamate metabolic process

[Term]
id: GO:0019545
name: arginine catabolic process to succinate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including succinate." [GOC:go_curators]
subset: gosubset_prok
synonym: "arginine breakdown to succinate" EXACT []
synonym: "arginine degradation to succinate" EXACT []
xref: MetaCyc:ARGDEG-III-PWY
xref: MetaCyc:ARGDEG-IV-PWY
xref: MetaCyc:ARGDEG-V-PWY
xref: MetaCyc:AST-PWY
is_a: GO:0006105 ! succinate metabolic process
is_a: GO:0006527 ! arginine catabolic process

[Term]
id: GO:0019546
name: arginine deiminase pathway
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including ornithine and CO2, using the enzyme arginine deiminase." [GOC:mah, MetaCyc:ARGDEGRAD-PWY]
subset: gosubset_prok
xref: MetaCyc:ARGDEGRAD-PWY
is_a: GO:0006527 ! arginine catabolic process

[Term]
id: GO:0019547
name: arginine catabolic process to ornithine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including ornithine." [GOC:go_curators]
subset: gosubset_prok
synonym: "arginine breakdown to ornithine" EXACT []
synonym: "arginine degradation to ornithine" EXACT []
is_a: GO:0006527 ! arginine catabolic process
is_a: GO:0006591 ! ornithine metabolic process

[Term]
id: GO:0019548
name: arginine catabolic process to spermine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including spermine." [GOC:go_curators]
subset: gosubset_prok
synonym: "arginine breakdown to spermine" EXACT []
synonym: "arginine degradation to spermine" EXACT []
xref: MetaCyc:ARGSPECAT-PWY
is_a: GO:0006527 ! arginine catabolic process
is_a: GO:0008215 ! spermine metabolic process

[Term]
id: GO:0019549
name: glutamate catabolic process to succinate via succinate semialdehyde
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glutamate into succinate, that includes the conversion of 4-aminobutyrate to succinate semialdehyde by the pyruvate-dependent gamma aminobutyrate (GABA) transaminase." [GOC:bf, GOC:go_curators, MetaCyc:PWY-4321]
comment: While mammals only have 2-oxoglutarate-dependent GABA-transaminase, both 2-oxoglutarate-dependent and pyruvate-dependent GABA-transaminase activities have been detected in plants.
subset: gosubset_prok
synonym: "glutamate breakdown to succinate" BROAD []
synonym: "glutamate catabolic process to succinate via pyruvate-dependent GABA-transaminase activity" EXACT []
synonym: "glutamate degradation to succinate" BROAD []
xref: MetaCyc:PWY-4321
is_a: GO:0006540 ! glutamate decarboxylation to succinate
relationship: has_part GO:0034387 ! 4-aminobutyrate:pyruvate transaminase activity

[Term]
id: GO:0019550
name: glutamate catabolic process to aspartate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including aspartate." [GOC:go_curators]
subset: gosubset_prok
synonym: "glutamate breakdown to aspartate" EXACT []
synonym: "glutamate degradation to aspartate" EXACT []
xref: MetaCyc:GLUTDEG-PWY
is_a: GO:0006531 ! aspartate metabolic process
is_a: GO:0006538 ! glutamate catabolic process

[Term]
id: GO:0019551
name: glutamate catabolic process to 2-oxoglutarate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including 2-oxoglutarate." [GOC:go_curators]
subset: gosubset_prok
synonym: "glutamate breakdown to 2-oxoglutarate" EXACT []
synonym: "glutamate catabolic process to 2-ketoglutarate" EXACT []
synonym: "glutamate catabolic process to alpha-ketoglutarate" EXACT []
synonym: "glutamate catabolic process to alpha-oxoglutarate" EXACT []
synonym: "glutamate catabolism to 2-ketoglutarate" EXACT []
synonym: "glutamate catabolism to alpha-ketoglutarate" EXACT []
synonym: "glutamate catabolism to alpha-oxoglutarate" EXACT []
synonym: "glutamate degradation to 2-oxoglutarate" EXACT []
xref: MetaCyc:GLUTAMATE-DEG1-PWY
xref: MetaCyc:PWY-5766
is_a: GO:0006103 ! 2-oxoglutarate metabolic process
is_a: GO:0006106 ! fumarate metabolic process
is_a: GO:0006538 ! glutamate catabolic process

[Term]
id: GO:0019552
name: glutamate catabolic process via 2-hydroxyglutarate
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate 2-hydroxyglutarate, yielding energy in the form of ATP." [MetaCyc:P162-PWY]
subset: gosubset_prok
synonym: "glutamate fermentation via 2-hydroxyglutarate" EXACT []
xref: MetaCyc:P162-PWY
is_a: GO:0019670 ! anaerobic glutamate catabolic process

[Term]
id: GO:0019553
name: glutamate catabolic process via L-citramalate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate L-citramalate." [GOC:go_curators]
subset: gosubset_prok
synonym: "glutamate breakdown via L-citramalate" EXACT []
synonym: "glutamate degradation via L-citramalate" EXACT []
xref: MetaCyc:GLUDEG-II-PWY
is_a: GO:0006538 ! glutamate catabolic process

[Term]
id: GO:0019554
name: glutamate catabolic process to oxaloacetate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including oxaloacetate." [GOC:go_curators]
subset: gosubset_prok
synonym: "glutamate breakdown to oxaloacetate" EXACT []
synonym: "glutamate degradation to oxaloacetate" EXACT []
is_a: GO:0006107 ! oxaloacetate metabolic process
is_a: GO:0006538 ! glutamate catabolic process
is_a: GO:0043650 ! dicarboxylic acid biosynthetic process

[Term]
id: GO:0019555
name: glutamate catabolic process to ornithine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including ornithine." [GOC:go_curators]
subset: gosubset_prok
synonym: "glutamate breakdown to ornithine" EXACT []
synonym: "glutamate degradation to ornithine" EXACT []
xref: MetaCyc:GLUTORN-PWY
is_a: GO:0006538 ! glutamate catabolic process
is_a: GO:0006591 ! ornithine metabolic process

[Term]
id: GO:0019556
name: histidine catabolic process to glutamate and formamide
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including glutamate and formamide." [GOC:go_curators]
subset: gosubset_prok
synonym: "histidine breakdown to glutamate and formamide" EXACT []
synonym: "histidine degradation to glutamate and formamide" EXACT []
xref: MetaCyc:HISDEG-PWY
is_a: GO:0006536 ! glutamate metabolic process
is_a: GO:0006548 ! histidine catabolic process
is_a: GO:0043606 ! formamide metabolic process

[Term]
id: GO:0019557
name: histidine catabolic process to glutamate and formate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including glutamate and formate." [GOC:go_curators]
subset: gosubset_prok
synonym: "histidine breakdown to glutamate and formate" EXACT []
synonym: "histidine degradation to glutamate and formate" EXACT []
is_a: GO:0006536 ! glutamate metabolic process
is_a: GO:0006548 ! histidine catabolic process
is_a: GO:0015942 ! formate metabolic process

[Term]
id: GO:0019558
name: histidine catabolic process to 2-oxoglutarate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including 2-oxoglutarate." [GOC:go_curators]
subset: gosubset_prok
synonym: "histidine breakdown to 2-oxoglutarate" EXACT []
synonym: "histidine catabolic process to 2-ketoglutarate" EXACT []
synonym: "histidine catabolic process to alpha-ketoglutarate" EXACT []
synonym: "histidine catabolic process to alpha-oxoglutarate" EXACT []
synonym: "histidine catabolism to 2-ketoglutarate" EXACT []
synonym: "histidine catabolism to alpha-ketoglutarate" EXACT []
synonym: "histidine catabolism to alpha-oxoglutarate" EXACT []
synonym: "histidine degradation to 2-oxoglutarate" EXACT []
is_a: GO:0006103 ! 2-oxoglutarate metabolic process
is_a: GO:0006548 ! histidine catabolic process

[Term]
id: GO:0019559
name: histidine catabolic process to imidazol-5-yl-lactate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including imidazol-5-yl-lactate." [GOC:go_curators]
subset: gosubset_prok
synonym: "histidine breakdown to imidazol-5-yl-lactate" EXACT []
synonym: "histidine degradation to imidazol-5-yl-lactate" EXACT []
xref: MetaCyc:HISTDEG-PWY
is_a: GO:0006548 ! histidine catabolic process

[Term]
id: GO:0019560
name: histidine catabolic process to hydantoin-5-propionate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including hydantoin-5-propionate." [GOC:go_curators]
subset: gosubset_prok
synonym: "histidine breakdown to hydantoin-5-propionate" EXACT []
synonym: "histidine degradation to hydantoin-5-propionate" EXACT []
xref: MetaCyc:HISHP-PWY
is_a: GO:0006548 ! histidine catabolic process

[Term]
id: GO:0019561
name: anaerobic phenylalanine oxidation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phenylalanine under anaerobic conditions; occurs via the intermediates phenylpyruvate and phenylacetaldehyde." [GOC:mah, MetaCyc:ANAPHENOXI-PWY]
subset: gosubset_prok
xref: MetaCyc:ANAPHENOXI-PWY
is_a: GO:0006559 ! L-phenylalanine catabolic process
is_a: GO:0055114 ! oxidation-reduction process

[Term]
id: GO:0019562
name: phenylalanine catabolic process to phosphoenolpyruvate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phenylalanine into other compounds, including phosphoenolpyruvate." [GOC:go_curators]
subset: gosubset_prok
synonym: "phenylalanine breakdown to phosphoenolpyruvate" EXACT []
synonym: "phenylalanine degradation to phosphoenolpyruvate" EXACT []
xref: MetaCyc:PHENYLALANINE-DEG1-PWY
is_a: GO:0006559 ! L-phenylalanine catabolic process
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0019563
name: glycerol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "glycerol breakdown" EXACT []
synonym: "glycerol catabolism" EXACT []
synonym: "glycerol degradation" EXACT []
xref: MetaCyc:PWY-4261
xref: MetaCyc:PWY0-381
is_a: GO:0006071 ! glycerol metabolic process
is_a: GO:0019405 ! alditol catabolic process

[Term]
id: GO:0019564
name: aerobic glycerol catabolic process
namespace: biological_process
alt_id: GO:0019565
def: "The chemical reactions and pathways resulting in the breakdown of glycerol, 1,2,3-propanetriol, in the presence of oxygen." [GOC:ai, ISBN:0198506732]
subset: gosubset_prok
synonym: "aerobic glycerol breakdown" EXACT []
synonym: "aerobic glycerol catabolism" EXACT []
synonym: "aerobic glycerol degradation" EXACT []
synonym: "aerobic glycerol fermentation" RELATED []
xref: MetaCyc:PWY0-381
is_a: GO:0019563 ! glycerol catabolic process

[Term]
id: GO:0019566
name: arabinose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving arabinose, arabino-pentose. L-Arabinose occurs both free, for example in the heartwood of many conifers, and in the combined state, as a constituent of plant hemicelluloses, bacterial polysaccharides etc. D-arabinose is a constituent of arabinonucleosides." [ISBN:0198506732]
subset: gosubset_prok
synonym: "arabinose metabolism" EXACT []
is_a: GO:0019321 ! pentose metabolic process

[Term]
id: GO:0019567
name: arabinose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of arabinose, arabino-pentose." [GOC:ai]
subset: gosubset_prok
synonym: "arabinose anabolism" EXACT []
synonym: "arabinose biosynthesis" EXACT []
synonym: "arabinose formation" EXACT []
synonym: "arabinose synthesis" EXACT []
is_a: GO:0019322 ! pentose biosynthetic process
is_a: GO:0019566 ! arabinose metabolic process

[Term]
id: GO:0019568
name: arabinose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of arabinose, arabino-pentose." [GOC:ai]
subset: gosubset_prok
synonym: "arabinose breakdown" EXACT []
synonym: "arabinose catabolism" EXACT []
synonym: "arabinose degradation" EXACT []
is_a: GO:0019323 ! pentose catabolic process
is_a: GO:0019566 ! arabinose metabolic process

[Term]
id: GO:0019569
name: L-arabinose catabolic process to xylulose 5-phosphate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-arabinose into other compounds, including xylulose 5-phosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "L-arabinose breakdown to xylulose 5-phosphate" EXACT []
synonym: "L-arabinose degradation to xylulose 5-phosphate" EXACT []
xref: MetaCyc:ARABCAT-PWY
is_a: GO:0019572 ! L-arabinose catabolic process
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:1901159 ! xylulose 5-phosphate biosynthetic process

[Term]
id: GO:0019570
name: L-arabinose catabolic process to 2-oxoglutarate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-arabinose into other compounds, including 2-oxoglutarate." [GOC:go_curators]
subset: gosubset_prok
synonym: "L-arabinose breakdown to 2-oxoglutarate" EXACT []
synonym: "L-arabinose catabolic process to 2-ketoglutarate" EXACT []
synonym: "L-arabinose catabolic process to alpha-ketoglutarate" EXACT []
synonym: "L-arabinose catabolic process to alpha-oxoglutarate" EXACT []
synonym: "L-arabinose catabolism to 2-ketoglutarate" EXACT []
synonym: "L-arabinose catabolism to alpha-ketoglutarate" EXACT []
synonym: "L-arabinose catabolism to alpha-oxoglutarate" EXACT []
synonym: "L-arabinose degradation to 2-oxoglutarate" EXACT []
is_a: GO:0006103 ! 2-oxoglutarate metabolic process
is_a: GO:0019572 ! L-arabinose catabolic process

[Term]
id: GO:0019571
name: D-arabinose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-arabinose, the D-enantiomer of arabino-pentose." [CHEBI:17108, GOC:go_curators, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "D-arabinose breakdown" EXACT []
synonym: "D-arabinose catabolism" EXACT []
synonym: "D-arabinose degradation" EXACT []
is_a: GO:0019568 ! arabinose catabolic process
is_a: GO:0046372 ! D-arabinose metabolic process

[Term]
id: GO:0019572
name: L-arabinose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-arabinose, the L-enantiomer of arabino-pentose." [CHEBI:30849, GOC:go_curators, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "L-arabinose breakdown" EXACT []
synonym: "L-arabinose catabolism" EXACT []
synonym: "L-arabinose degradation" EXACT []
is_a: GO:0019568 ! arabinose catabolic process
is_a: GO:0046373 ! L-arabinose metabolic process

[Term]
id: GO:0019573
name: D-arabinose catabolic process to xylulose 5-phosphate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-arabinose to form xylulose 5-phosphate. D-arabinose is converted into D-ribulose, which is phosphorylated to ribulose-5-phosphate, which is isomerized to give D-xylulose-5-phosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "D-arabinose breakdown to xylulose 5-phosphate" EXACT []
synonym: "D-arabinose degradation to xylulose 5-phosphate" EXACT []
xref: MetaCyc:DARABCAT-PWY
is_a: GO:0019571 ! D-arabinose catabolic process
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:1901159 ! xylulose 5-phosphate biosynthetic process

[Term]
id: GO:0019574
name: sucrose catabolic process via 3'-ketosucrose
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of sucrose, which proceeds via the conversion of sucrose to 3'-ketosucrose. 3'-ketosucrose is hydrolyzed to 3-ketoglucose and fructose, and the 3-ketoglucose is then be converted to glucose." [GOC:bf, GOC:dgf, MetaCyc:SUCROSEUTIL2-PWY]
subset: gosubset_prok
synonym: "sucrose breakdown, using glucoside 3-dehydrogenase" EXACT []
synonym: "sucrose catabolic process to D-glucose" EXACT [GOC:bf, MetaCyc:SUCROSEUTIL2-PWY]
synonym: "sucrose catabolic process, using glucoside 3-dehydrogenase" EXACT [GOC:bf, MetaCyc:SUCROSEUTIL2-PWY]
synonym: "sucrose catabolism, using glucoside 3-dehydrogenase" EXACT []
synonym: "sucrose degradation, using glucoside 3-dehydrogenase" EXACT []
xref: MetaCyc:SUCROSEUTIL2-PWY
is_a: GO:0005987 ! sucrose catabolic process
is_a: GO:0006006 ! glucose metabolic process
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process
relationship: has_part GO:0008865 ! fructokinase activity
relationship: has_part GO:0048258 ! 3-ketoglucose-reductase activity

[Term]
id: GO:0019575
name: obsolete sucrose catabolic process, using beta-fructofuranosidase
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of sucrose, catalyzed by the enzyme beta-fructofuranosidase (EC:3.2.1.26)." [GOC:jl]
comment: This term was made obsolete because beta-fructofuranosidase (also known as invertase) catalyzes the first step in multiple routes of sucrose catabolism.
subset: gosubset_prok
synonym: "sucrose breakdown, using beta-fructofuranosidase" EXACT []
synonym: "sucrose catabolic process, using beta-fructofuranosidase" EXACT []
synonym: "sucrose catabolism, using beta-fructofuranosidase" EXACT []
synonym: "sucrose degradation, using beta-fructofuranosidase" EXACT []
xref: MetaCyc:SUCUTIL-PWY
is_obsolete: true
consider: GO:0004564
consider: GO:0036008

[Term]
id: GO:0019576
name: aerobic fructose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of fructose that occurs in the presence of oxygen." [GOC:ai]
subset: gosubset_prok
synonym: "aerobic fructose breakdown" EXACT []
synonym: "aerobic fructose catabolism" EXACT []
synonym: "aerobic fructose degradation" EXACT []
is_a: GO:0006001 ! fructose catabolic process

[Term]
id: GO:0019577
name: aldaric acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aldaric acid, any dicarboxylic acid formed by oxidation of by the terminal groups of an aldose to carboxyl group." [ISBN:0198506732]
subset: gosubset_prok
synonym: "aldaric acid metabolism" EXACT []
is_a: GO:0043648 ! dicarboxylic acid metabolic process
is_a: GO:0044723 ! single-organism carbohydrate metabolic process

[Term]
id: GO:0019578
name: aldaric acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of aldaric acid, any dicarboxylic acid formed by oxidation of by the terminal groups of an aldose to carboxyl group." [ISBN:0198506732]
subset: gosubset_prok
synonym: "aldaric acid anabolism" EXACT []
synonym: "aldaric acid biosynthesis" EXACT []
synonym: "aldaric acid formation" EXACT []
synonym: "aldaric acid synthesis" EXACT []
is_a: GO:0016051 ! carbohydrate biosynthetic process
is_a: GO:0019577 ! aldaric acid metabolic process
is_a: GO:0043650 ! dicarboxylic acid biosynthetic process

[Term]
id: GO:0019579
name: aldaric acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of aldaric acid, any dicarboxylic acid formed by oxidation of by the terminal groups of an aldose to carboxyl group." [ISBN:0198506732]
subset: gosubset_prok
synonym: "aldaric acid breakdown" EXACT []
synonym: "aldaric acid catabolism" EXACT []
synonym: "aldaric acid degradation" EXACT []
is_a: GO:0019577 ! aldaric acid metabolic process
is_a: GO:0043649 ! dicarboxylic acid catabolic process
is_a: GO:0044724 ! single-organism carbohydrate catabolic process

[Term]
id: GO:0019580
name: galactarate metabolic process
namespace: biological_process
alt_id: GO:0046393
def: "The chemical reactions and pathways involving galactarate, an anion of galactaric acid, the meso-aldaric acid derived from both D- and L-galactose." [GOC:pr, ISBN:0198506732]
subset: gosubset_prok
synonym: "D-galactarate metabolic process" RELATED []
synonym: "D-galactarate metabolism" RELATED []
synonym: "galactarate metabolism" EXACT []
synonym: "mucic acid metabolic process" EXACT []
synonym: "mucic acid metabolism" EXACT []
is_a: GO:0019577 ! aldaric acid metabolic process

[Term]
id: GO:0019583
name: galactonate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving galactonate, the anion of galactonic acid, an organic acid derived from the sugar galactose." [GOC:ai]
subset: gosubset_prok
synonym: "galactonate metabolism" EXACT []
is_a: GO:0019520 ! aldonic acid metabolic process

[Term]
id: GO:0019584
name: galactonate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of galactonate, the anion of galactonic acid." [GOC:ai]
subset: gosubset_prok
synonym: "galactonate breakdown" EXACT []
synonym: "galactonate catabolism" EXACT []
synonym: "galactonate degradation" EXACT []
xref: MetaCyc:GALACTCAT-PWY
is_a: GO:0019583 ! galactonate metabolic process
is_a: GO:0046176 ! aldonic acid catabolic process

[Term]
id: GO:0019585
name: glucuronate metabolic process
namespace: biological_process
alt_id: GO:0019699
def: "The chemical reactions and pathways involving glucuronate, any salt or ester of glucuronic acid, the uronic acid formally derived from glucose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "glucuronate metabolism" EXACT []
xref: Wikipedia:Glucuronic_acid
is_a: GO:0006063 ! uronic acid metabolic process

[Term]
id: GO:0019586
name: galacturonate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving galacturonate, the anion of galacturonic acid, the uronic acid formally derived from galactose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group." [ISBN:0198506732]
subset: gosubset_prok
synonym: "galacturonate metabolism" EXACT []
is_a: GO:0006063 ! uronic acid metabolic process

[Term]
id: GO:0019588
name: anaerobic glycerol catabolic process
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glycerol, yielding energy in the form of ATP." [GOC:mah]
subset: gosubset_prok
synonym: "glycerol fermentation" EXACT []
is_a: GO:0019563 ! glycerol catabolic process
is_a: GO:0019662 ! non-glycolytic fermentation

[Term]
id: GO:0019589
name: anaerobic glycerol catabolic process to propane-1,3-diol
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glycerol into propane-1,3-diol and water." [GOC:jl, MetaCyc:GOLPDLCAT-PWY]
subset: gosubset_prok
synonym: "glycerol fermentation to 1,3-propanediol" EXACT []
synonym: "glycerol fermentation to propane-1,3-diol" EXACT []
xref: MetaCyc:GOLPDLCAT-PWY
is_a: GO:0019588 ! anaerobic glycerol catabolic process
is_a: GO:0051143 ! propanediol metabolic process

[Term]
id: GO:0019590
name: L-arabitol catabolic process to xylulose 5-phosphate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-arabitol to form xylulose 5-phosphate. L-arabitol is converted into L-xylulose, which is then phosphorylated to L-xylulose-5-phosphate. This is converted to D-xylulose-5-phosphate via the intermediate L-ribulose-5-phosphate." [MetaCyc:LARABITOLUTIL-PWY]
subset: gosubset_prok
synonym: "L-arabitol and xylitol degradation" BROAD []
synonym: "L-arabitol breakdown to xylulose 5-phosphate" EXACT []
synonym: "L-arabitol degradation to xylulose 5-phosphate" EXACT []
synonym: "L-arabitol utilization" RELATED []
xref: MetaCyc:LARABITOLUTIL-PWY
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:0051158 ! L-arabitol catabolic process
is_a: GO:1901159 ! xylulose 5-phosphate biosynthetic process

[Term]
id: GO:0019592
name: mannitol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of mannitol, the alditol derived from D-mannose by reduction of the aldehyde group." [ISBN:0198506732]
subset: gosubset_prok
synonym: "mannitol breakdown" EXACT []
synonym: "mannitol catabolism" EXACT []
synonym: "mannitol degradation" EXACT []
xref: MetaCyc:MANNIDEG-PWY
xref: MetaCyc:PWY-3861
is_a: GO:0019407 ! hexitol catabolic process
is_a: GO:0019594 ! mannitol metabolic process

[Term]
id: GO:0019593
name: mannitol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of mannitol, the alditol derived from D-mannose by reduction of the aldehyde group." [ISBN:0198506732]
subset: gosubset_prok
synonym: "mannitol anabolism" EXACT []
synonym: "mannitol biosynthesis" EXACT []
synonym: "mannitol formation" EXACT []
synonym: "mannitol synthesis" EXACT []
xref: MetaCyc:PWY-3881
is_a: GO:0019406 ! hexitol biosynthetic process
is_a: GO:0019594 ! mannitol metabolic process

[Term]
id: GO:0019594
name: mannitol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mannitol, the alditol derived from D-mannose by reduction of the aldehyde group." [ISBN:0198506732]
subset: gosubset_prok
synonym: "mannitol metabolism" EXACT []
is_a: GO:0006059 ! hexitol metabolic process

[Term]
id: GO:0019595
name: non-phosphorylated glucose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of non-phosphorylated forms of glucose." [GOC:ai]
subset: gosubset_prok
synonym: "non-phosphorylated glucose breakdown" EXACT []
synonym: "non-phosphorylated glucose catabolism" EXACT []
synonym: "non-phosphorylated glucose degradation" EXACT []
xref: MetaCyc:NPGLUCAT-PWY
is_a: GO:0006007 ! glucose catabolic process
is_a: GO:0046430 ! non-phosphorylated glucose metabolic process

[Term]
id: GO:0019596
name: mandelate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of mandelate, the anion of mandelic acid. Mandelic acid (alpha-hydroxybenzeneacetic acid) is an 8-carbon alpha-hydroxy acid (AHA) that is used in organic chemistry and as a urinary antiseptic." [GOC:go_curators]
subset: gosubset_prok
synonym: "mandelate breakdown" EXACT []
synonym: "mandelate catabolism" EXACT []
synonym: "mandelate degradation" EXACT []
is_a: GO:0018924 ! mandelate metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901616 ! organic hydroxy compound catabolic process

[Term]
id: GO:0019597
name: (R)-mandelate catabolic process to benzoate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of (R)-mandelate into other compounds, including benzoate." [GOC:go_curators]
subset: gosubset_prok
synonym: "(R)-mandelate breakdown to benzoate" EXACT []
synonym: "(R)-mandelate degradation to benzoate" EXACT []
is_a: GO:0018874 ! benzoate metabolic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0019596 ! mandelate catabolic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process

[Term]
id: GO:0019598
name: (R)-mandelate catabolic process to catechol
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of (R)-mandelate into other compounds, including catechol." [GOC:go_curators]
subset: gosubset_prok
synonym: "(R)-mandelate breakdown to catechol" EXACT []
synonym: "(R)-mandelate degradation to catechol" EXACT []
is_a: GO:0009713 ! catechol-containing compound biosynthetic process
is_a: GO:0019596 ! mandelate catabolic process
is_a: GO:0044711 ! single-organism biosynthetic process

[Term]
id: GO:0019599
name: (R)-4-hydroxymandelate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of (R)-4-hydroxymandelate, the anion of (R)-4-hydroxymandelic acid." [GOC:ai]
subset: gosubset_prok
synonym: "(R)-4-hydroxymandelate breakdown" EXACT []
synonym: "(R)-4-hydroxymandelate catabolism" EXACT []
synonym: "(R)-4-hydroxymandelate degradation" EXACT []
xref: MetaCyc:4-HYDROXYMANDELATE-DEGRADATION-PWY
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0046431 ! (R)-4-hydroxymandelate metabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0019600
name: toluene oxidation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the loss of electrons from one or more atoms in toluene." [GOC:mah]
subset: gosubset_prok
is_a: GO:0018970 ! toluene metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0055114 ! oxidation-reduction process

[Term]
id: GO:0019601
name: toluene oxidation via 2-hydroxytoluene
namespace: biological_process
def: "The degradation of toluene to form pyruvate and acetaldehyde; the first step in the pathway is the oxidation of toluene to form 2-hydroxytoluene (o-cresol)." [MetaCyc:TOLUENE-DEG-2-OH-PWY]
subset: gosubset_prok
xref: MetaCyc:TOLUENE-DEG-2-OH-PWY
is_a: GO:0019600 ! toluene oxidation

[Term]
id: GO:0019602
name: toluene oxidation via 3-hydroxytoluene
namespace: biological_process
def: "The degradation of toluene to form pyruvate and acetaldehyde; the first step in the pathway is the oxidation of toluene to form 3-hydroxytoluene (m-cresol)." [MetaCyc:TOLUENE-DEG-3-OH-PWY]
subset: gosubset_prok
xref: MetaCyc:TOLUENE-DEG-3-OH-PWY
is_a: GO:0019600 ! toluene oxidation

[Term]
id: GO:0019603
name: toluene oxidation via 4-hydroxytoluene
namespace: biological_process
def: "The degradation of toluene to form p-hydroxybenzoate; the first step in the pathway is the oxidation of toluene to form 4-hydroxytoluene (4-cresol)." [MetaCyc:TOLUENE-DEG-4-OH-PWY]
subset: gosubset_prok
xref: MetaCyc:TOLUENE-DEG-4-OH-PWY
is_a: GO:0019600 ! toluene oxidation

[Term]
id: GO:0019604
name: toluene oxidation to catechol
namespace: biological_process
def: "The formation from toluene of catechol, dihydroxybenzene, by successive oxidations followed by loss of carbon dioxide (CO2)." [MetaCyc:TOLUENE-DEG-CATECHOL-PWY]
subset: gosubset_prok
xref: MetaCyc:TOLUENE-DEG-CATECHOL-PWY
xref: UM-BBD_pathwayID:tol
is_a: GO:0009712 ! catechol-containing compound metabolic process
is_a: GO:0019600 ! toluene oxidation

[Term]
id: GO:0019605
name: butyrate metabolic process
namespace: biological_process
alt_id: GO:0043437
def: "The chemical reactions and pathways involving any butyrate, the anions of butyric acid (butanoic acid), a saturated, unbranched aliphatic acid." [ISBN:0198506732]
subset: gosubset_prok
synonym: "butanoic acid metabolic process" EXACT []
synonym: "butanoic acid metabolism" EXACT []
synonym: "butyrate metabolism" EXACT []
synonym: "butyric acid metabolic process" EXACT []
synonym: "butyric acid metabolism" EXACT []
is_a: GO:0046459 ! short-chain fatty acid metabolic process

[Term]
id: GO:0019606
name: 2-oxobutyrate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 2-oxobutyrate, the anion of the organic acid 2-oxobutyric acid, which contains a ketone group on carbon 2." [ISBN:0198506732]
subset: gosubset_prok
synonym: "2-oxobutyrate breakdown" EXACT []
synonym: "2-oxobutyrate catabolism" EXACT []
synonym: "2-oxobutyrate degradation" EXACT []
synonym: "alpha-ketobutyrate catabolic process" EXACT []
synonym: "alpha-ketobutyrate catabolism" EXACT []
xref: MetaCyc:2OXOBUTYRATECAT-PWY
is_a: GO:0019626 ! short-chain fatty acid catabolic process
is_a: GO:0046361 ! 2-oxobutyrate metabolic process

[Term]
id: GO:0019607
name: phenylethylamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phenylethylamine, an amine with pharmacological properties similar to those of amphetamine, occurs naturally as a neurotransmitter in the brain, and is present in chocolate and oil of bitter almonds." [GOC:jl, ISBN:0395825172]
synonym: "phenylethylamine breakdown" EXACT []
synonym: "phenylethylamine catabolism" EXACT []
synonym: "phenylethylamine degradation" EXACT []
xref: MetaCyc:2PHENDEG-PWY
is_a: GO:0042402 ! cellular biogenic amine catabolic process
is_a: GO:0042443 ! phenylethylamine metabolic process
is_a: GO:1901161 ! primary amino compound catabolic process

[Term]
id: GO:0019608
name: nicotine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of nicotine, (S)(-)-3-(1-methyl-2-pyrrolidinyl)pyridine." [GOC:sm, ISBN:0198547684]
subset: gosubset_prok
synonym: "nicotine breakdown" EXACT []
synonym: "nicotine catabolism" EXACT []
synonym: "nicotine degradation" EXACT []
xref: MetaCyc:P181-PWY
xref: UM-BBD_pathwayID:nic
is_a: GO:0009822 ! alkaloid catabolic process
is_a: GO:0018933 ! nicotine metabolic process
is_a: GO:0072526 ! pyridine-containing compound catabolic process

[Term]
id: GO:0019609
name: 3-hydroxyphenylacetate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 3-hydroxyphenylacetate, 1,3-benzenediol monoacetate, also known as resorcinol monoacetate." [http://chemfinder.cambridgesoft.com/]
subset: gosubset_prok
synonym: "3-hydroxyphenylacetate metabolism" EXACT []
synonym: "3HPA metabolic process" EXACT []
synonym: "3HPA metabolism" EXACT []
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0019610
name: 3-hydroxyphenylacetate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 3-hydroxyphenylacetate, 1,3-benzenediol monoacetate, also known as resorcinol monoacetate." [http://chemfinder.cambridgesoft.com/]
subset: gosubset_prok
synonym: "3-hydroxyphenylacetate breakdown" EXACT []
synonym: "3-hydroxyphenylacetate catabolism" EXACT []
synonym: "3-hydroxyphenylacetate degradation" EXACT []
xref: MetaCyc:3-HYDROXYPHENYLACETATE-DEGRADATION-PWY
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0019609 ! 3-hydroxyphenylacetate metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0019611
name: 4-toluenecarboxylate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 4-toluenecarboxylate, 4-methylbenzenecarboxylate, the anion of carboxylic acid attached to a methylbenzene molecule." [GOC:ai]
subset: gosubset_prok
synonym: "4-toluenecarboxylate metabolism" EXACT []
synonym: "p-toluate metabolic process" EXACT []
synonym: "p-toluate metabolism" EXACT []
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0072490 ! toluene-containing compound metabolic process

[Term]
id: GO:0019612
name: 4-toluenecarboxylate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 4-toluenecarboxylate, 4-methylbenzenecarboxylate, the anion of carboxylic acid attached to a methylbenzene molecule." [GOC:ai]
subset: gosubset_prok
synonym: "4-toluenecarboxylate breakdown" EXACT []
synonym: "4-toluenecarboxylate catabolism" EXACT []
synonym: "4-toluenecarboxylate degradation" EXACT []
synonym: "p-toluate catabolic process" EXACT []
synonym: "p-toluate catabolism" EXACT []
xref: MetaCyc:4TOLCARBDEG-PWY
is_a: GO:0019611 ! 4-toluenecarboxylate metabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:0072491 ! toluene-containing compound catabolic process

[Term]
id: GO:0019614
name: catechol-containing compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent." [GOC:go_curators]
subset: gosubset_prok
synonym: "catechol breakdown" RELATED []
synonym: "catechol catabolic process" RELATED []
synonym: "catechol catabolism" RELATED []
synonym: "catechol degradation" RELATED []
is_a: GO:0009712 ! catechol-containing compound metabolic process
is_a: GO:0019336 ! phenol-containing compound catabolic process

[Term]
id: GO:0019615
name: catechol catabolic process, ortho-cleavage
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of catechol via the ortho-cleavage pathway, in which the catechol aromatic ring is broken between the two carbon atoms bearing hydroxyl groups." [GOC:jl, http://www.ence.umd.edu/]
subset: gosubset_prok
synonym: "catechol breakdown, ortho-cleavage" EXACT []
synonym: "catechol degradation, ortho-cleavage" EXACT []
xref: MetaCyc:CATECHOL-ORTHO-CLEAVAGE-PWY
is_a: GO:0019614 ! catechol-containing compound catabolic process
is_a: GO:0042952 ! beta-ketoadipate pathway

[Term]
id: GO:0019616
name: catechol catabolic process, meta-cleavage
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of catechol via the meta-cleavage pathway, in which the catechol aromatic ring is broken between a hydroxylated carbon atom and an adjacent unsubstituted carbon atom." [GOC:jl, http://www.ence.umd.edu/]
subset: gosubset_prok
synonym: "catechol breakdown, meta-cleavage" EXACT []
synonym: "catechol degradation, meta-cleavage" EXACT []
xref: MetaCyc:P183-PWY
is_a: GO:0019614 ! catechol-containing compound catabolic process

[Term]
id: GO:0019617
name: protocatechuate catabolic process, meta-cleavage
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of protocatechuate, the anion of 3,4-dihydroxybenzoic acid, to yield oxaloacetate and pyruvate." [MetaCyc:P184-PWY]
subset: gosubset_prok
synonym: "3,4-dihydroxybenzoate catabolic process, meta-cleavage" RELATED [CHEBI:36241]
synonym: "protocatechuate breakdown, meta-cleavage" EXACT []
synonym: "protocatechuate catabolic process to oxaloacetate and pyruvate" EXACT []
synonym: "protocatechuate degradation, meta-cleavage" EXACT []
xref: MetaCyc:P184-PWY
is_a: GO:0006090 ! pyruvate metabolic process
is_a: GO:0006107 ! oxaloacetate metabolic process
is_a: GO:0019619 ! 3,4-dihydroxybenzoate catabolic process

[Term]
id: GO:0019618
name: protocatechuate catabolic process, ortho-cleavage
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of protocatechuate, the anion of 3,4-dihydroxybenzoic acid, to yield beta-ketoadipate." [MetaCyc:PROTOCATECHUATE-ORTHO-CLEAVAGE-PWY]
subset: gosubset_prok
synonym: "3,4-dihydroxybenzoate catabolic process, ortho-cleavage" EXACT [CHEBI:36241]
synonym: "protocatechuate breakdown, ortho-cleavage" EXACT []
synonym: "protocatechuate catabolic process to beta-ketoadipate" EXACT []
synonym: "protocatechuate degradation, ortho-cleavage" EXACT []
xref: MetaCyc:PROTOCATECHUATE-ORTHO-CLEAVAGE-PWY
is_a: GO:0019619 ! 3,4-dihydroxybenzoate catabolic process
is_a: GO:0043648 ! dicarboxylic acid metabolic process

[Term]
id: GO:0019619
name: 3,4-dihydroxybenzoate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of  3,4-dihydroxybenzoate." [GOC:ai]
subset: gosubset_prok
synonym: "protocatechuate breakdown" EXACT []
synonym: "protocatechuate catabolic process" EXACT [CHEBI:36241]
synonym: "protocatechuate catabolism" EXACT []
synonym: "protocatechuate degradation" EXACT []
is_a: GO:0019614 ! catechol-containing compound catabolic process
is_a: GO:0046278 ! 3,4-dihydroxybenzoate metabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0019620
name: aerobic benzoate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving benzoate, the anion of benzoic acid (benzenecarboxylic acid) that occur in the presence of oxygen." [GOC:ai]
subset: gosubset_prok
synonym: "aerobic benzoate metabolism" EXACT []
is_a: GO:0018874 ! benzoate metabolic process

[Term]
id: GO:0019621
name: creatinine catabolic process to formate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of creatinine into other compounds, including formate." [GOC:go_curators]
subset: gosubset_prok
synonym: "creatinine breakdown to formate" EXACT []
synonym: "creatinine degradation to formate" EXACT []
xref: MetaCyc:CRNFORCAT-PWY
is_a: GO:0006602 ! creatinine catabolic process
is_a: GO:0015942 ! formate metabolic process

[Term]
id: GO:0019622
name: 3-(3-hydroxy)phenylpropionate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 3-(3-hydroxy)phenylpropionate, a hydroxylated derivative of phenylpropionate." [GOC:ai]
subset: gosubset_prok
synonym: "3-(3-hydroxy)phenylpropionate breakdown" EXACT []
synonym: "3-(3-hydroxy)phenylpropionate catabolism" EXACT []
synonym: "3-(3-hydroxy)phenylpropionate degradation" EXACT []
xref: MetaCyc:HCAMHPDEG-PWY
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0046164 ! alcohol catabolic process
is_a: GO:0046435 ! 3-(3-hydroxy)phenylpropionate metabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process

[Term]
id: GO:0019623
name: atrazine catabolic process to urea
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide, into urea." [GOC:jl]
subset: gosubset_prok
synonym: "atrazine breakdown to urea" EXACT []
synonym: "atrazine degradation to urea" EXACT []
is_a: GO:0019381 ! atrazine catabolic process
is_a: GO:0019627 ! urea metabolic process
is_a: GO:0044712 ! single-organism catabolic process

[Term]
id: GO:0019624
name: atrazine catabolic process to isopropylamine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide, into isopropylamine." [GOC:jl]
subset: gosubset_prok
synonym: "atrazine breakdown to isopropylamine" EXACT []
synonym: "atrazine degradation to isopropylamine" EXACT []
is_a: GO:0009308 ! amine metabolic process
is_a: GO:0019381 ! atrazine catabolic process
is_a: GO:0097164 ! ammonium ion metabolic process
is_a: GO:1901160 ! primary amino compound metabolic process

[Term]
id: GO:0019625
name: atrazine catabolic process to cyanuric acid
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide, into cyanuric acid." [GOC:jl]
subset: gosubset_prok
synonym: "atrazine breakdown to cyanuric acid" EXACT []
synonym: "atrazine degradation to cyanuric acid" EXACT []
xref: MetaCyc:P141-PWY
is_a: GO:0019381 ! atrazine catabolic process
is_a: GO:0042199 ! cyanuric acid metabolic process

[Term]
id: GO:0019626
name: short-chain fatty acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of fatty acids with a chain length of less than C6." [CHEBI:26666, ISBN:0198506732]
subset: gosubset_prok
synonym: "short-chain fatty acid breakdown" EXACT []
synonym: "short-chain fatty acid catabolism" EXACT []
synonym: "short-chain fatty acid degradation" EXACT []
xref: MetaCyc:ACETOACETATE-DEG-PWY
xref: Reactome:REACT_103450 "Propionyl-CoA catabolism, Taeniopygia guttata"
xref: Reactome:REACT_103545 "Propionyl-CoA catabolism, Canis familiaris"
xref: Reactome:REACT_104178 "Propionyl-CoA catabolism, Gallus gallus"
xref: Reactome:REACT_104697 "Propionyl-CoA catabolism, Bos taurus"
xref: Reactome:REACT_105518 "Propionyl-CoA catabolism, Caenorhabditis elegans"
xref: Reactome:REACT_105872 "Propionyl-CoA catabolism, Sus scrofa"
xref: Reactome:REACT_79110 "Propionyl-CoA catabolism, Escherichia coli"
xref: Reactome:REACT_81066 "Propionyl-CoA catabolism, Danio rerio"
xref: Reactome:REACT_82962 "Propionyl-CoA catabolism, Dictyostelium discoideum"
xref: Reactome:REACT_84214 "Propionyl-CoA catabolism, Mycobacterium tuberculosis"
xref: Reactome:REACT_87902 "Propionyl-CoA catabolism, Rattus norvegicus"
xref: Reactome:REACT_90789 "Propionyl-CoA catabolism, Xenopus tropicalis"
xref: Reactome:REACT_91227 "Propionyl-CoA catabolism, Mus musculus"
xref: Reactome:REACT_993 "Propionyl-CoA catabolism, Homo sapiens"
is_a: GO:0009062 ! fatty acid catabolic process
is_a: GO:0046459 ! short-chain fatty acid metabolic process

[Term]
id: GO:0019627
name: urea metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving urea, the water soluble compound O=C-(NH2)2." [ISBN:0198506732]
subset: gosubset_prok
synonym: "urea metabolism" EXACT []
is_a: GO:0043603 ! cellular amide metabolic process
is_a: GO:0044281 ! small molecule metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0071941 ! nitrogen cycle metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process

[Term]
id: GO:0019628
name: urate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of urate, the anion of uric acid, 2,6,8-trioxypurine." [ISBN:0198506732]
subset: gosubset_prok
synonym: "urate breakdown" EXACT []
synonym: "urate catabolism" EXACT []
synonym: "urate degradation" EXACT []
synonym: "uric acid catabolic process" EXACT []
xref: MetaCyc:P165-PWY
is_a: GO:0044282 ! small molecule catabolic process
is_a: GO:0046415 ! urate metabolic process
is_a: GO:0072523 ! purine-containing compound catabolic process

[Term]
id: GO:0019629
name: propionate catabolic process, 2-methylcitrate cycle
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of propionate that occurs in the 2-methylcitrate cycle." [GOC:go_curators]
subset: gosubset_prok
synonym: "propionate breakdown, 2-methylcitrate cycle" EXACT []
synonym: "propionate degradation, 2-methylcitrate cycle" EXACT []
is_a: GO:0019543 ! propionate catabolic process

[Term]
id: GO:0019630
name: quinate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving quinate, the anion of quinic acid. The acid occurs commonly in plants, either free or as esters, and is used as a medicine." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "quinate metabolism" EXACT []
synonym: "quinic acid metabolic process" EXACT []
synonym: "quinic acid metabolism" EXACT []
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process

[Term]
id: GO:0019631
name: quinate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of quinate, the anion of quinic acid." [GOC:jl]
subset: gosubset_prok
synonym: "quinate breakdown" EXACT []
synonym: "quinate catabolism" EXACT []
synonym: "quinate degradation" EXACT []
synonym: "quinic acid catabolic process" EXACT []
synonym: "quinic acid catabolism" EXACT []
xref: MetaCyc:QUINATEDEG-PWY
is_a: GO:0019630 ! quinate metabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901616 ! organic hydroxy compound catabolic process

[Term]
id: GO:0019632
name: shikimate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving shikimate, (3R,4S,5R)--3,4,5-trihydroxycyclohex-1-ene-1-carboxylate, the anion of shikimic acid. It is an important intermediate in the biosynthesis of aromatic amino acids." [CHEBI:36208, GOC:sm, ISBN:0198547684]
subset: gosubset_prok
synonym: "shikimate metabolism" EXACT []
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process

[Term]
id: GO:0019633
name: shikimate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of shikimate, (3R,4S,5R)--3,4,5-trihydroxycyclohex-1-ene-1-carboxylate, the anion of shikimic acid." [CHEBI:36208, GOC:go_curators]
subset: gosubset_prok
synonym: "shikimate breakdown" EXACT []
synonym: "shikimate catabolism" EXACT []
synonym: "shikimate degradation" EXACT []
xref: MetaCyc:SHIKIMATEDEG-PWY
is_a: GO:0019632 ! shikimate metabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:1901616 ! organic hydroxy compound catabolic process

[Term]
id: GO:0019634
name: organic phosphonate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phosphonates, any organic compounds containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Metabolism of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included." [GOC:js, ISBN:0721662544]
subset: gosubset_prok
synonym: "organophosphonate metabolic process" RELATED []
synonym: "phosphonate metabolism" EXACT []
is_a: GO:0019637 ! organophosphate metabolic process

[Term]
id: GO:0019635
name: 2-aminoethylphosphonate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 2-aminoethylphosphonate, also known as ciliatine." [GOC:ai]
subset: gosubset_prok
synonym: "2-aminoethylphosphonate breakdown" EXACT []
synonym: "2-aminoethylphosphonate catabolism" EXACT []
synonym: "2-aminoethylphosphonate degradation" EXACT []
synonym: "2-phosphonoethylamine catabolic process" EXACT []
synonym: "2-phosphonoethylamine catabolism" EXACT []
synonym: "ciliatine catabolic process" EXACT []
synonym: "ciliatine catabolism" EXACT []
xref: MetaCyc:PHOSPHONOTASE-PWY
is_a: GO:0046433 ! 2-aminoethylphosphonate metabolic process
is_a: GO:1901161 ! primary amino compound catabolic process

[Term]
id: GO:0019636
name: phosphonoacetate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phosphonoacetate, C2H4PO5, a substance composed of an acetate and a phosphonic acid residue." [MetaCyc:P483-PWY]
subset: gosubset_prok
synonym: "phosphonoacetate metabolism" EXACT []
xref: MetaCyc:P483-PWY
is_a: GO:0006793 ! phosphorus metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0019637
name: organophosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving organophosphates, any phosphate-containing organic compound." [ISBN:0198506732]
subset: gosubset_prok
synonym: "organophosphate metabolism" EXACT []
is_a: GO:0006793 ! phosphorus metabolic process
is_a: GO:0071704 ! organic substance metabolic process

[Term]
id: GO:0019638
name: 6-hydroxycineole metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 6-hydroxycineole (6-hydroxy-1,8-epoxy-p-menthane), a hydrocarbon with the formula C10H18O2." [GOC:ai]
subset: gosubset_prok
synonym: "6-endo-hydroxycineole metabolic process" EXACT []
synonym: "6-endo-hydroxycineole metabolism" EXACT []
synonym: "6-hydroxycineole metabolism" EXACT []
synonym: "hydroxycineol metabolic process" EXACT []
synonym: "hydroxycineol metabolism" EXACT []
is_a: GO:0016098 ! monoterpenoid metabolic process
is_a: GO:0097176 ! epoxide metabolic process

[Term]
id: GO:0019639
name: 6-hydroxycineole catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 6-hydroxycineole (6-hydroxy-1,8-epoxy-p-menthane), a hydrocarbon with the formula C10H18O2." [GOC:ai]
subset: gosubset_prok
synonym: "6-endo-hydroxycineole catabolic process" EXACT []
synonym: "6-endo-hydroxycineole catabolism" EXACT []
synonym: "6-hydroxycineole breakdown" EXACT []
synonym: "6-hydroxycineole catabolism" EXACT []
synonym: "6-hydroxycineole degradation" EXACT []
synonym: "hydroxycineol catabolic process" EXACT []
synonym: "hydroxycineol catabolism" EXACT []
xref: MetaCyc:6-HYDROXYCINEOLE-DEGRADATION-PWY
is_a: GO:0016100 ! monoterpenoid catabolic process
is_a: GO:0019638 ! 6-hydroxycineole metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901502 ! ether catabolic process

[Term]
id: GO:0019640
name: glucuronate catabolic process to xylulose 5-phosphate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glucuronate into other compounds, including xylulose 5-phosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "glucuronate breakdown to xylulose 5-phosphate" EXACT []
synonym: "glucuronate degradation to xylulose 5-phosphate" EXACT []
is_a: GO:0006064 ! glucuronate catabolic process
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:1901159 ! xylulose 5-phosphate biosynthetic process

[Term]
id: GO:0019643
name: reductive tricarboxylic acid cycle
namespace: biological_process
alt_id: GO:0019644
def: "A pathway leading to the fixation of two molecules of CO2 and the production of one molecule of acetyl-CoA; essentially the oxidative TCA cycle running in reverse. Acetyl-CoA is reductively carboxylated to pyruvate, from which all other central metabolites can be formed. Most of the enzymes of reductive and oxidative TCA cycle are shared, with the exception of three key enzymes that allow the cycle to run in reverse: ATP citrate lyase, 2-oxoglutarate:ferredoxin oxidoreductase, and fumarate reductase. 2-oxoglutarate:ferredoxin oxidoreductase catalyzes the carboxylation of succinyl-CoA to 2-oxoglutarate, ATP citrate lyase the ATP-dependent cleavage of citrate to acetyl-CoA and oxaloacetate, and fumarate reductase the reduction of fumarate forming succinate." [GOC:jl, PMID:15838028]
subset: gosubset_prok
synonym: "reductive carboxylate cycle" EXACT []
synonym: "reductive carboxylic acid cycle" EXACT []
synonym: "reductive citric acid pathway" EXACT []
synonym: "reductive Kreb's cycle" EXACT []
synonym: "reductive TCA cycle" EXACT []
xref: MetaCyc:P23-PWY
xref: MetaCyc:REDCITCYC
is_a: GO:0006099 ! tricarboxylic acid cycle
is_a: GO:0015977 ! carbon fixation

[Term]
id: GO:0019645
name: anaerobic electron transport chain
namespace: biological_process
def: "A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors other than oxygen to generate a transmembrane electrochemical gradient." [GOC:ai, GOC:mtg_electron_transport]
subset: gosubset_prok
is_a: GO:0022904 ! respiratory electron transport chain
relationship: part_of GO:0009061 ! anaerobic respiration

[Term]
id: GO:0019646
name: aerobic electron transport chain
namespace: biological_process
alt_id: GO:0006136
alt_id: GO:0006137
alt_id: GO:0006138
def: "A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to oxygen to generate a transmembrane electrochemical gradient." [GOC:ai, GOC:mtg_electron_transport]
subset: gosubset_prok
synonym: "NADH-O2 electron transport" NARROW []
synonym: "succinate-O2 electron transport" NARROW []
synonym: "ubiquinone-8-O2 electron transport" NARROW []
is_a: GO:0009060 ! aerobic respiration
is_a: GO:0022904 ! respiratory electron transport chain

[Term]
id: GO:0019647
name: formaldehyde assimilation via ribulose monophosphate cycle
namespace: biological_process
def: "The pathway in which formaldehyde is used as a carbon source in the ribulose monophosphate cycle. Methanotrophic bacteria produce formaldehyde from the oxidation of methane and methanol, and then assimilate it via the ribulose monophosphate cycle to form intermediates of the central metabolic routes that are subsequently used for biosynthesis of cell material. Three molecules of formaldehyde are assimilated, forming a three-carbon intermediate of central metabolism; in this pathway, all cellular carbon is assimilated at the oxidation level of formaldehyde." [MetaCyc:PWY-1861]
subset: gosubset_prok
synonym: "formaldehyde assimilation via RuMP cycle" EXACT []
synonym: "ribulose monophosphate cycle" BROAD []
xref: MetaCyc:PWY-1861
is_a: GO:0019649 ! formaldehyde assimilation

[Term]
id: GO:0019648
name: formaldehyde assimilation via xylulose monophosphate cycle
namespace: biological_process
def: "The pathway in which formaldehyde is used as a carbon source in the xylulose monophosphate cycle. Methylotrophic yeasts, but not bacteria, utilize the xylulose monophosphate cycle to fix formaldehyde and convert it into metabolically useful organic compounds." [MetaCyc:P185-PWY]
subset: gosubset_prok
synonym: "formaldehyde assimilation via xylulose-5-phosphate cycle" EXACT []
synonym: "formaldehyde fixation cycle" EXACT []
xref: MetaCyc:P185-PWY
is_a: GO:0019649 ! formaldehyde assimilation
is_a: GO:0051167 ! xylulose 5-phosphate metabolic process

[Term]
id: GO:0019649
name: formaldehyde assimilation
namespace: biological_process
def: "The pathways in which formaldehyde is processed and used as a carbon source for the cell." [GOC:ai]
subset: gosubset_prok
is_a: GO:0046292 ! formaldehyde metabolic process

[Term]
id: GO:0019650
name: glycolytic fermentation to butanediol
namespace: biological_process
alt_id: GO:0030646
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glucose into butanediol; effected by some members of the Enterobacteriaceae, e.g. Enterobacter, Erwinia, Klebsiella, and Serratia." [GOC:dph, GOC:nr, ISBN:0198506732]
subset: gosubset_prok
synonym: "butanediol fermentation" EXACT []
synonym: "glucose catabolic process to butanediol" EXACT [GOC:dph]
synonym: "glucose fermentation to butanediol" EXACT []
xref: MetaCyc:P125-PWY
xref: Wikipedia:Butanediol_fermentation
is_a: GO:0006007 ! glucose catabolic process
is_a: GO:0019364 ! pyridine nucleotide catabolic process
is_a: GO:0019660 ! glycolytic fermentation
is_a: GO:0034077 ! butanediol metabolic process
relationship: has_part GO:0003984 ! acetolactate synthase activity
relationship: has_part GO:0047605 ! acetolactate decarboxylase activity
relationship: has_part GO:0052587 ! diacetyl reductase ((R)-acetoin forming) activity

[Term]
id: GO:0019651
name: citrate catabolic process to diacetyl
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of citrate to diacetyl, yielding energy in the form of ATP." [MetaCyc:P126-PWY]
subset: gosubset_prok
synonym: "citrate fermentation to diacetyl" EXACT []
synonym: "diacetyl fermentation" EXACT []
is_a: GO:0006101 ! citrate metabolic process
is_a: GO:0019662 ! non-glycolytic fermentation
is_a: GO:0042180 ! cellular ketone metabolic process
is_a: GO:0072352 ! tricarboxylic acid catabolic process

[Term]
id: GO:0019652
name: lactate fermentation to propionate and acetate
namespace: biological_process
def: "The anaerobic enzymatic conversion of lactate to propionate, concomitant with the oxidation of lactate to acetate and CO2 and yielding energy in the form of adenosine triphosphate (ATP)." [GOC:jl, MetaCyc:PROPFERM-PWY]
subset: gosubset_prok
synonym: "acrylate pathway" EXACT []
synonym: "nonrandomizing pathway" EXACT []
synonym: "propionate fermentation" EXACT []
xref: MetaCyc:PROPFERM-PWY
is_a: GO:0019541 ! propionate metabolic process
is_a: GO:0019662 ! non-glycolytic fermentation

[Term]
id: GO:0019653
name: anaerobic purine nucleobase catabolic process
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of purine nucleobases, yielding energy in the form of ATP." [CHEBI:26386, GOC:mah]
subset: gosubset_prok
synonym: "anaerobic purine base catabolic process" EXACT [GOC:go_curators]
synonym: "anaerobic purine base catabolism" EXACT [GOC:curators]
synonym: "anaerobic purine catabolic process" RELATED [GOC:curators]
synonym: "purine base fermentation" EXACT [GOC:curators]
synonym: "purine fermentation" RELATED [GOC:curators]
xref: MetaCyc:P164-PWY
xref: MetaCyc:PWY-5044
xref: MetaCyc:PWY-5497
is_a: GO:0006145 ! purine nucleobase catabolic process
is_a: GO:0019666 ! nitrogenous compound fermentation

[Term]
id: GO:0019654
name: acetate fermentation
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of acetate, yielding energy in the form of ATP." [CHEBI:30089, GOC:jl, MetaCyc:P142-PWY]
subset: gosubset_prok
xref: MetaCyc:P142-PWY
is_a: GO:0006083 ! acetate metabolic process
is_a: GO:0006113 ! fermentation

[Term]
id: GO:0019655
name: glycolytic fermentation to ethanol
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glucose; it is converted into ethanol and carbon dioxide (CO2), producing two molecules of ATP for each molecule of glucose." [GOC:dph, GOC:nr, ISBN:0716720094]
subset: gosubset_prok
synonym: "alcoholic fermentation" RELATED [ISBN:124925502]
synonym: "ethanol fermentation" EXACT []
synonym: "glucose catabolic process to ethanol" EXACT [GOC:dph]
synonym: "glucose fermentation to ethanol" EXACT []
xref: Wikipedia:Ethanol_fermentation
is_a: GO:0006007 ! glucose catabolic process
is_a: GO:0006734 ! NADH metabolic process
is_a: GO:0019660 ! glycolytic fermentation
is_a: GO:1902707 ! hexose catabolic process to ethanol

[Term]
id: GO:0019656
name: glucose catabolic process to D-lactate and ethanol
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the enzymatic breakdown of D-glucose to D-lactate and ethanol, yielding energy in the form of adenosine triphosphate (ATP) at the rate of one ATP per glucose molecule." [GOC:jl, MetaCyc:P122-PWY]
subset: gosubset_prok
synonym: "glucose fermentation to D-lactate and ethanol" EXACT []
synonym: "heterofermentation" EXACT []
synonym: "heterofermentative lactate fermentation" EXACT []
synonym: "heterofermentative pathway" EXACT []
synonym: "heterolactate fermentation" EXACT []
synonym: "heterolactic fermentation" EXACT []
xref: MetaCyc:P122-PWY
is_a: GO:0019659 ! glucose catabolic process to lactate
is_a: GO:0019662 ! non-glycolytic fermentation
is_a: GO:1902707 ! hexose catabolic process to ethanol

[Term]
id: GO:0019657
name: glycolytic fermentation to propionate
namespace: biological_process
def: "Glycolytic fermentation resulting in the catabolism of glucose to propionate, yielding energy in the form of ATP; an alternative to the acrylate pathway to produce propionate." [GOC:dph, GOC:nr, MetaCyc:P108-PWY]
subset: gosubset_prok
synonym: "succinate-propionate fermentation" EXACT []
xref: MetaCyc:P108-PWY
is_a: GO:0006007 ! glucose catabolic process
is_a: GO:0006105 ! succinate metabolic process
is_a: GO:0006734 ! NADH metabolic process
is_a: GO:0019541 ! propionate metabolic process
is_a: GO:0019660 ! glycolytic fermentation
is_a: GO:0042867 ! pyruvate catabolic process
relationship: has_part GO:0043821 ! propionyl-CoA:succinate CoA-transferase activity
relationship: has_part GO:0047154 ! methylmalonyl-CoA carboxytransferase activity

[Term]
id: GO:0019658
name: glucose fermentation to lactate and acetate
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glucose to lactate and acetate, yielding energy in the form of ATP." [MetaCyc:P124-PWY]
subset: gosubset_prok
synonym: "bifidum pathway" EXACT []
synonym: "glucose catabolic process to lactate and acetate" BROAD []
xref: MetaCyc:P124-PWY
is_a: GO:0019659 ! glucose catabolic process to lactate
is_a: GO:0019662 ! non-glycolytic fermentation
is_a: GO:1902706 ! hexose catabolic process to acetate

[Term]
id: GO:0019659
name: glucose catabolic process to lactate
namespace: biological_process
def: "The anaerobic enzymatic chemical reactions and pathways resulting in the breakdown of glucose to lactate, and possibly ethanol, yielding energy in the form of adenosine triphosphate (ATP)." [GOC:jl]
subset: gosubset_prok
synonym: "glucose fermentation to lactate" EXACT []
synonym: "lactate fermentation" EXACT []
xref: Wikipedia:Lactic_acid_fermentation
is_a: GO:0006007 ! glucose catabolic process
is_a: GO:0006089 ! lactate metabolic process
is_a: GO:0006113 ! fermentation

[Term]
id: GO:0019660
name: glycolytic fermentation
namespace: biological_process
def: "Fermentation that includes the anaerobic conversion of glucose to pyruvate via the glycolytic pathway." [GOC:curators]
subset: gosubset_prok
xref: MetaCyc:Pyruvate-Degredation
is_a: GO:0006090 ! pyruvate metabolic process
is_a: GO:0006113 ! fermentation
is_a: GO:0044723 ! single-organism carbohydrate metabolic process
is_a: GO:0046031 ! ADP metabolic process
is_a: GO:0046034 ! ATP metabolic process
is_a: GO:0046496 ! nicotinamide nucleotide metabolic process

[Term]
id: GO:0019661
name: glucose catabolic process to lactate via pyruvate
namespace: biological_process
def: "The anaerobic enzymatic chemical reactions and pathways resulting in the breakdown of glucose to lactate, via canonical glycolysis, yielding energy in the form of adenosine triphosphate (ATP)." [GOC:jl]
subset: gosubset_prok
synonym: "glucose fermentation to lactate via pyruvate" EXACT []
synonym: "homofermentation" EXACT []
synonym: "homofermentative lactate fermentation" EXACT []
synonym: "homofermentative pathway" EXACT []
synonym: "homolactate fermentation" EXACT []
synonym: "homolactic fermentation" EXACT [ISBN:124925502]
xref: MetaCyc:ANAEROFRUCAT-PWY
is_a: GO:0006734 ! NADH metabolic process
is_a: GO:0019659 ! glucose catabolic process to lactate
is_a: GO:0019660 ! glycolytic fermentation

[Term]
id: GO:0019662
name: non-glycolytic fermentation
namespace: biological_process
def: "Fermentation that does not include the anaerobic conversion of glucose to pyruvate via the glycolytic pathway." [GOC:jl, MetaCyc:Fermentation]
subset: gosubset_prok
is_a: GO:0006113 ! fermentation

[Term]
id: GO:0019664
name: mixed acid fermentation
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glucose into ethanol, lactate, formate, succinate, and acetate, yielding energy in the form of ATP." [MetaCyc:FERMENTATION-PWY, PMID:124925502]
subset: gosubset_prok
synonym: "glucose catabolic process to mixed acids" BROAD []
synonym: "glucose fermentation to mixed acids" EXACT []
xref: Wikipedia:Mixed_acid_fermentation
is_a: GO:0006006 ! glucose metabolic process
is_a: GO:0006067 ! ethanol metabolic process
is_a: GO:0006083 ! acetate metabolic process
is_a: GO:0006089 ! lactate metabolic process
is_a: GO:0006103 ! 2-oxoglutarate metabolic process
is_a: GO:0006105 ! succinate metabolic process
is_a: GO:0015942 ! formate metabolic process
is_a: GO:0019660 ! glycolytic fermentation

[Term]
id: GO:0019665
name: anaerobic amino acid catabolic process
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of amino acids, yielding energy in the form of ATP." [GOC:curators, GOC:jl, MetaCyc:Fermentation]
subset: gosubset_prok
synonym: "amino acid fermentation" EXACT []
is_a: GO:0006113 ! fermentation
is_a: GO:0009063 ! cellular amino acid catabolic process

[Term]
id: GO:0019666
name: nitrogenous compound fermentation
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of a nitrogen-containing compound, yielding energy in the form of ATP." [GOC:mah]
subset: gosubset_prok
synonym: "nitrogenous compound catabolic process" BROAD []
is_a: GO:0006113 ! fermentation

[Term]
id: GO:0019667
name: anaerobic L-alanine catabolic process
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of L-alanine, yielding energy in the form of ATP." [GOC:jl]
subset: gosubset_prok
synonym: "L-alanine fermentation" EXACT []
is_a: GO:0019665 ! anaerobic amino acid catabolic process
is_a: GO:0042853 ! L-alanine catabolic process

[Term]
id: GO:0019668
name: anaerobic catabolism of pairs of amino acids
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of amino acids; in these reactions, one amino acid is oxidised (acts as an electron donor) and a different amino acid is reduced (acts as an electron acceptor); oxidation of the electron-donating amino acid yields energy in the form of ATP." [GOC:mah, PMID:13140081]
subset: gosubset_prok
synonym: "cofermentation of pairs of amino acids" EXACT []
synonym: "Stickland reaction" NARROW []
is_a: GO:0019665 ! anaerobic amino acid catabolic process

[Term]
id: GO:0019669
name: anaerobic glycine catabolic process
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glycine, yielding energy in the form of ATP." [GOC:jl]
subset: gosubset_prok
synonym: "glycine fermentation" EXACT []
is_a: GO:0006546 ! glycine catabolic process
is_a: GO:0019665 ! anaerobic amino acid catabolic process

[Term]
id: GO:0019670
name: anaerobic glutamate catabolic process
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glutamate, yielding energy in the form of ATP." [GOC:jl]
subset: gosubset_prok
synonym: "glutamate fermentation" EXACT []
is_a: GO:0006538 ! glutamate catabolic process
is_a: GO:0019665 ! anaerobic amino acid catabolic process

[Term]
id: GO:0019671
name: glutamate catabolic process via mesaconate and citramalate
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glutamate via the intermediates mesaconate and S-citramalate, yielding energy in the form of ATP." [MetaCyc:GLUDEG-II-PWY]
subset: gosubset_prok
synonym: "glutamate fermentation via mesaconate and citramalate" EXACT []
xref: MetaCyc:GLUDEG-II-PWY
xref: MetaCyc:PWY-5087
xref: MetaCyc:PWY-5088
is_a: GO:0019670 ! anaerobic glutamate catabolic process

[Term]
id: GO:0019672
name: ethanol-acetate fermentation to butyrate and caproate
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of ethanol and acetate to butyrate and caproate, yielding energy in the form of ATP." [MetaCyc:P127-PWY]
subset: gosubset_prok
is_a: GO:0019662 ! non-glycolytic fermentation

[Term]
id: GO:0019673
name: GDP-mannose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "GDP-mannose metabolism" EXACT []
is_a: GO:0009225 ! nucleotide-sugar metabolic process

[Term]
id: GO:0019674
name: NAD metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid." [GOC:jl, ISBN:0618254153]
subset: gosubset_prok
synonym: "NAD (oxidized) metabolic process" EXACT []
synonym: "NAD (oxidized) metabolism" EXACT []
synonym: "NAD metabolism" EXACT []
synonym: "NAD phosphorylation and dephosphorylation" NARROW []
synonym: "nicotinamide adenine dinucleotide metabolic process" EXACT []
synonym: "nicotinamide adenine dinucleotide metabolism" EXACT []
synonym: "oxidized NAD metabolic process" EXACT []
synonym: "oxidized NAD metabolism" EXACT []
synonym: "oxidized nicotinamide adenine dinucleotide metabolic process" EXACT []
synonym: "oxidized nicotinamide adenine dinucleotide metabolism" EXACT []
xref: Reactome:REACT_102478 "Nicotinate metabolism, Saccharomyces cerevisiae"
xref: Reactome:REACT_104567 "Nicotinate metabolism, Xenopus tropicalis"
xref: Reactome:REACT_105395 "Nicotinate metabolism, Dictyostelium discoideum"
xref: Reactome:REACT_110196 "Nicotinate metabolism, Gallus gallus"
xref: Reactome:REACT_11088 "Nicotinate metabolism, Homo sapiens"
xref: Reactome:REACT_28199 "Nicotinate metabolism, Drosophila melanogaster"
xref: Reactome:REACT_29368 "Nicotinate metabolism, Schizosaccharomyces pombe"
xref: Reactome:REACT_30661 "Nicotinate metabolism, Rattus norvegicus"
xref: Reactome:REACT_31735 "Nicotinate metabolism, Canis familiaris"
xref: Reactome:REACT_32189 "Nicotinate metabolism, Staphylococcus aureus N315"
xref: Reactome:REACT_32534 "Nicotinate metabolism, Caenorhabditis elegans"
xref: Reactome:REACT_78879 "Nicotinate metabolism, Plasmodium falciparum"
xref: Reactome:REACT_79139 "Nicotinate metabolism, Bos taurus"
xref: Reactome:REACT_82947 "Nicotinate metabolism, Danio rerio"
xref: Reactome:REACT_84027 "Nicotinate metabolism, Mycobacterium tuberculosis"
xref: Reactome:REACT_87078 "Nicotinate metabolism, Oryza sativa"
xref: Reactome:REACT_89072 "Nicotinate metabolism, Sus scrofa"
xref: Reactome:REACT_90573 "Nicotinate metabolism, Mus musculus"
xref: Reactome:REACT_94163 "Nicotinate metabolism, Arabidopsis thaliana"
xref: Reactome:REACT_96354 "Nicotinate metabolism, Taeniopygia guttata"
xref: Reactome:REACT_96854 "Nicotinate metabolism, Escherichia coli"
is_a: GO:0046496 ! nicotinamide nucleotide metabolic process

[Term]
id: GO:0019675
name: obsolete NAD phosphorylation and dephosphorylation
namespace: biological_process
def: "OBSOLETE. The addition or removal of a phosphate group from nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid." [GOC:jl, ISBN:0618254153]
comment: This term was made obsolete because it represents a process, NAD dephosphorylation, that does not exist.
synonym: "NAD phosphorylation and dephosphorylation" EXACT []
synonym: "nicotinamide adenine dinucleotide phosphorylation and dephosphorylation" EXACT []
is_obsolete: true
consider: GO:0006739
consider: GO:0019674

[Term]
id: GO:0019676
name: ammonia assimilation cycle
namespace: biological_process
def: "The pathway by which ammonia is processed and incorporated into a cell. In an energy-rich (glucose-containing), nitrogen-poor environment, glutamine synthetase and glutamate synthase form an ammonia assimilatory cycle, in which ammonia is incorporated into L-glutamate to form L-glutamine, which then combines with alpha-ketoglutarate to regenerate L-glutamate. This ATP-dependent cycle is essential for nitrogen-limited growth and for steady-state growth with some sources of nitrogen." [MetaCyc:AMMASSIM-PWY]
subset: gosubset_prok
synonym: "glutamate metabolic process via glutamine and ammonia" EXACT []
synonym: "glutamate metabolism via glutamine and ammonia" EXACT []
xref: MetaCyc:AMMASSIM-PWY
xref: MetaCyc:PWY-3282
is_a: GO:0006536 ! glutamate metabolic process
is_a: GO:0006541 ! glutamine metabolic process

[Term]
id: GO:0019677
name: NAD catabolic process
namespace: biological_process
alt_id: GO:0006737
def: "The chemical reactions and pathways resulting in the breakdown of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; catabolism may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:jl, ISBN:0618254153]
subset: gosubset_prok
synonym: "NAD (oxidized) catabolic process" EXACT []
synonym: "NAD (oxidized) catabolism" EXACT []
synonym: "NAD (reduced) catabolic process" EXACT []
synonym: "NAD (reduced) catabolism" EXACT []
synonym: "NAD breakdown" EXACT []
synonym: "NAD catabolism" EXACT []
synonym: "NAD degradation" EXACT []
synonym: "NADH catabolic process" EXACT []
synonym: "NADH catabolism" EXACT []
synonym: "nicotinamide adenine dinucleotide catabolic process" EXACT []
synonym: "nicotinamide adenine dinucleotide catabolism" EXACT []
synonym: "oxidized NAD catabolic process" EXACT []
synonym: "oxidized NAD catabolism" EXACT []
synonym: "oxidized nicotinamide adenine dinucleotide catabolic process" EXACT []
synonym: "oxidized nicotinamide adenine dinucleotide catabolism" EXACT []
synonym: "reduced NAD catabolic process" EXACT []
synonym: "reduced NAD catabolism" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide catabolic process" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide catabolism" EXACT []
is_a: GO:0019364 ! pyridine nucleotide catabolic process
is_a: GO:0019674 ! NAD metabolic process

[Term]
id: GO:0019678
name: propionate metabolic process, methylmalonyl pathway
namespace: biological_process
def: "The chemical reactions and pathways involving propionate that occur in the methylmalonyl pathway." [GOC:go_curators]
subset: gosubset_prok
synonym: "propionate metabolism, methylmalonyl pathway" EXACT []
xref: MetaCyc:PROPIONMET-PWY
is_a: GO:0019541 ! propionate metabolic process

[Term]
id: GO:0019679
name: propionate metabolic process, methylcitrate cycle
namespace: biological_process
def: "The chemical reactions and pathways involving propionate that occur in the methylcitrate cycle." [GOC:go_curators]
subset: gosubset_prok
synonym: "propionate metabolism, methylcitrate cycle" EXACT []
xref: MetaCyc:PWY0-42
is_a: GO:0019541 ! propionate metabolic process

[Term]
id: GO:0019680
name: L-methylmalonyl-CoA biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-methylmalonyl-CoA, the L-enantiomer of 2-carboxypropanoyl-CoA." [GOC:ai, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "L-methylmalonyl-CoA anabolism" EXACT []
synonym: "L-methylmalonyl-CoA biosynthesis" EXACT []
synonym: "L-methylmalonyl-CoA formation" EXACT []
synonym: "L-methylmalonyl-CoA synthesis" EXACT []
xref: MetaCyc:PWY0-43
is_a: GO:0015937 ! coenzyme A biosynthetic process
is_a: GO:0046491 ! L-methylmalonyl-CoA metabolic process
is_a: GO:0046949 ! fatty-acyl-CoA biosynthetic process

[Term]
id: GO:0019681
name: acetyl-CoA assimilation pathway
namespace: biological_process
def: "The pathways by which acetyl-CoA is processed and converted into alpha-ketoglutarate (2-oxoglutarate); methanogenic archaea use these pathways to assimilate acetyl-CoA into the cell." [MetaCyc:P22-PWY]
subset: gosubset_prok
synonym: "acetyl-CoA catabolic process to 2-ketoglutarate" EXACT []
synonym: "acetyl-CoA catabolic process to 2-oxoglutarate" EXACT []
synonym: "acetyl-CoA catabolic process to alpha-ketoglutarate" EXACT []
synonym: "acetyl-CoA catabolic process to alpha-oxoglutarate" EXACT []
synonym: "acetyl-CoA catabolism to 2-ketoglutarate" EXACT []
synonym: "acetyl-CoA catabolism to 2-oxoglutarate" EXACT []
synonym: "acetyl-CoA catabolism to alpha-ketoglutarate" EXACT []
synonym: "acetyl-CoA catabolism to alpha-oxoglutarate" EXACT []
is_a: GO:0006103 ! 2-oxoglutarate metabolic process
is_a: GO:0044712 ! single-organism catabolic process
is_a: GO:0046356 ! acetyl-CoA catabolic process

[Term]
id: GO:0019682
name: glyceraldehyde-3-phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glyceraldehyde-3-phosphate, an important intermediate in glycolysis." [GOC:ai, ISBN:0198506732]
subset: gosubset_prok
synonym: "glyceraldehyde 3-phosphate metabolic process" EXACT []
synonym: "glyceraldehyde 3-phosphate metabolism" EXACT []
synonym: "glyceraldehyde-3-phosphate metabolism" EXACT []
is_a: GO:0006081 ! cellular aldehyde metabolic process
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:0019683
name: glyceraldehyde-3-phosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glyceraldehyde-3-phosphate, an important intermediate in glycolysis." [ISBN:0198506732]
subset: gosubset_prok
synonym: "glyceraldehyde 3-phosphate catabolic process" EXACT []
synonym: "glyceraldehyde 3-phosphate catabolism" EXACT []
synonym: "glyceraldehyde-3-phosphate breakdown" EXACT []
synonym: "glyceraldehyde-3-phosphate catabolism" EXACT []
synonym: "glyceraldehyde-3-phosphate degradation" EXACT []
is_a: GO:0019682 ! glyceraldehyde-3-phosphate metabolic process
is_a: GO:0046185 ! aldehyde catabolic process
is_a: GO:0046434 ! organophosphate catabolic process
is_a: GO:1901136 ! carbohydrate derivative catabolic process

[Term]
id: GO:0019684
name: photosynthesis, light reaction
namespace: biological_process
def: "The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I." [http://www.arabidopsis.org]
synonym: "photolysis" RELATED []
xref: MetaCyc:PWY-101
xref: Wikipedia:Photolysis#Photolysis_in_photosynthesis
is_a: GO:0006091 ! generation of precursor metabolites and energy
relationship: part_of GO:0015979 ! photosynthesis

[Term]
id: GO:0019685
name: photosynthesis, dark reaction
namespace: biological_process
def: "A complex cycle of enzyme-mediated reactions which catalyzes the reduction of carbon dioxide to sugar. As well as carbon dioxide the cycle requires reducing power in the form of reduced nicotinamide adenine dinucleotide phosphate (NADP) and chemical energy in the form of adenosine triphosphate (ATP). The reduced NADP (NADPH) and ATP are produced by the 'light' reactions." [ISBN:0582015952]
is_a: GO:0016051 ! carbohydrate biosynthetic process
relationship: part_of GO:0015979 ! photosynthesis

[Term]
id: GO:0019686
name: purine nucleoside interconversion
namespace: biological_process
def: "The chemical reactions and pathways by which a purine nucleoside is synthesized from another purine nucleoside." [GOC:mah, ISBN:0306444747, ISBN:0471394831]
subset: gosubset_prok
is_a: GO:0015949 ! nucleobase-containing small molecule interconversion
is_a: GO:0042278 ! purine nucleoside metabolic process

[Term]
id: GO:0019687
name: pyruvate biosynthetic process from acetate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyruvate from other compounds, including acetate." [GOC:go_curators]
subset: gosubset_prok
synonym: "pyruvate anabolism from acetate" EXACT []
synonym: "pyruvate formation from acetate" EXACT []
synonym: "pyruvate synthesis from acetate" EXACT []
is_a: GO:0006083 ! acetate metabolic process
is_a: GO:0042866 ! pyruvate biosynthetic process

[Term]
id: GO:0019688
name: purine deoxyribonucleoside interconversion
namespace: biological_process
def: "The chemical reactions and pathways by which a purine deoxyribonucleoside is synthesized from another purine deoxyribonucleoside." [GOC:mah, ISBN:0306444747, ISBN:0471394831]
subset: gosubset_prok
is_a: GO:0019686 ! purine nucleoside interconversion
is_a: GO:0046122 ! purine deoxyribonucleoside metabolic process

[Term]
id: GO:0019689
name: pyrimidine nucleoside interconversion
namespace: biological_process
def: "The chemical reactions and pathways by which a pyrimidine nucleoside is synthesized from another pyrimidine nucleoside." [GOC:mah, ISBN:0306444747, ISBN:0471394831]
subset: gosubset_prok
is_a: GO:0006213 ! pyrimidine nucleoside metabolic process
is_a: GO:0015949 ! nucleobase-containing small molecule interconversion

[Term]
id: GO:0019690
name: pyrimidine deoxyribonucleoside interconversion
namespace: biological_process
def: "The chemical reactions and pathways by which a pyrimidine deoxyribonucleoside is synthesized from another deoxyribopyrimidine nucleoside." [GOC:mah, ISBN:0306444747, ISBN:0471394831]
subset: gosubset_prok
is_a: GO:0019689 ! pyrimidine nucleoside interconversion
is_a: GO:0046125 ! pyrimidine deoxyribonucleoside metabolic process

[Term]
id: GO:0019692
name: deoxyribose phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose." [ISBN:0198506732]
subset: gosubset_prok
synonym: "deoxyribose phosphate metabolism" EXACT []
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:0019693
name: ribose phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ribose phosphate, any phosphorylated ribose sugar." [GOC:ai]
subset: gosubset_prok
synonym: "ribose phosphate metabolism" EXACT []
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:0019694
name: alkanesulfonate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon group." [GOC:ai]
subset: gosubset_prok
synonym: "alkanesulfonate metabolism" EXACT []
synonym: "alkanesulphonate metabolic process" EXACT []
synonym: "alkanesulphonate metabolism" EXACT []
xref: MetaCyc:ALKANEMONOX-PWY
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0044710 ! single-organism metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0071704 ! organic substance metabolic process

[Term]
id: GO:0019695
name: choline metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine." [GOC:jl, ISBN:0192801023]
subset: gosubset_prok
synonym: "choline metabolism" EXACT []
is_a: GO:0042439 ! ethanolamine-containing compound metabolic process
is_a: GO:0097164 ! ammonium ion metabolic process

[Term]
id: GO:0019696
name: toluene oxidation via toluene-cis-1,2-dihydrodiol
namespace: biological_process
def: "The degradation of toluene to form pyruvate and acetaldehyde; the first step in the pathway is the oxidation of toluene to form toluene-cis-1,2-dihydrodiol." [MetaCyc:TOLUENE-DEG-DIOL-PWY]
subset: gosubset_prok
xref: MetaCyc:TOLUENE-DEG-DIOL-PWY
is_a: GO:0019600 ! toluene oxidation

[Term]
id: GO:0019697
name: L-xylitol catabolic process to xylulose 5-phosphate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-xylitol to form xylulose 5-phosphate. L-xylitol is converted into L-xylulose, which is then phosphorylated to L-xylulose-5-phosphate. This is converted to D-xylulose-5-phosphate via the intermediate L-ribulose-5-phosphate." [MetaCyc:LARABITOLUTIL-PWY]
subset: gosubset_prok
synonym: "L-arabitol and xylitol degradation" BROAD []
synonym: "L-xylitol breakdown to xylulose 5-phosphate" EXACT []
synonym: "L-xylitol degradation to xylulose 5-phosphate" EXACT []
synonym: "L-xylitol utilization" RELATED []
xref: MetaCyc:LARABITOLUTIL-PWY
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:0051160 ! L-xylitol catabolic process
is_a: GO:1901159 ! xylulose 5-phosphate biosynthetic process

[Term]
id: GO:0019698
name: D-galacturonate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-galacturonate, the D-enantiomer of galacturonate, the anion of galacturonic acid." [GOC:ai, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "D-galacturonate breakdown" EXACT []
synonym: "D-galacturonate catabolism" EXACT []
synonym: "D-galacturonate degradation" EXACT []
xref: MetaCyc:GALACTUROCAT-PWY
is_a: GO:0046396 ! D-galacturonate metabolic process
is_a: GO:0046397 ! galacturonate catabolic process

[Term]
id: GO:0019700
name: organic phosphonate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phosphonates, any organic compound containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Catabolism of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included." [GOC:js]
subset: gosubset_prok
synonym: "organophosphonate catabolic process" RELATED []
synonym: "phosphonate breakdown" EXACT []
synonym: "phosphonate catabolism" EXACT []
synonym: "phosphonate degradation" EXACT []
is_a: GO:0019634 ! organic phosphonate metabolic process
is_a: GO:0046434 ! organophosphate catabolic process

[Term]
id: GO:0019701
name: peptidyl-arginine N5-methylation
namespace: biological_process
def: "The methylation of peptidyl-arginine on the internal nitrogen-5 (N5) atom (also called delta-nitrogen) to form peptidyl-N5-methyl-L-arginine." [GOC:bf, PMID:9792625, RESID:AA0305]
subset: gosubset_prok
synonym: "peptidyl-arginine delta-N-methylation" EXACT []
xref: RESID:AA0305
is_a: GO:0035246 ! peptidyl-arginine N-methylation

[Term]
id: GO:0019702
name: protein-arginine N5-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the delta-nitrogen atom of peptidyl-arginine residues." [PMID:9873020]
synonym: "protein-arginine delta-N-methyltransferase activity" EXACT []
synonym: "type IV PRMT activity" EXACT []
synonym: "type IV protein arginine methyltransferase activity" EXACT []
xref: EC:2.1.1.-
is_a: GO:0016274 ! protein-arginine N-methyltransferase activity

[Term]
id: GO:0019703
name: coenzyme A-peptidyl-cysteine covalent linking
namespace: biological_process
def: "The covalent linkage of coenzyme A and peptidyl-cysteine to form L-cysteine coenzyme A disulfide." [RESID:AA0306]
subset: gosubset_prok
xref: RESID:AA0306
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0019704
name: peptidyl-S-myristoyl-L-cysteine biosynthetic process from peptidyl-cysteine
namespace: biological_process
def: "The modification of peptidyl-cysteine to form peptidyl-S-myristoyl-L-cysteine." [RESID:AA0307]
subset: gosubset_prok
synonym: "peptidyl-S-myristoyl-L-cysteine anabolism from peptidyl-cysteine" EXACT []
synonym: "peptidyl-S-myristoyl-L-cysteine formation from peptidyl-cysteine" EXACT []
synonym: "peptidyl-S-myristoyl-L-cysteine synthesis from peptidyl-cysteine" EXACT []
xref: RESID:AA0307
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018377 ! protein myristoylation

[Term]
id: GO:0019705
name: protein-cysteine S-myristoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a myristoyl group to a sulfur atom on a cysteine residue of a protein molecule." [GOC:ai]
xref: EC:2.3.1.-
is_a: GO:0019107 ! myristoyltransferase activity
is_a: GO:0019707 ! protein-cysteine S-acyltransferase activity

[Term]
id: GO:0019706
name: protein-cysteine S-palmitoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a palmitoyl group to a sulfur atom on the cysteine of a protein molecule." [EC:2.3.1.225, GOC:ai, GOC:pr]
synonym: "protein-cysteine S-palmitoleyltransferase activity" RELATED []
xref: EC:2.3.1.225
is_a: GO:0016409 ! palmitoyltransferase activity
is_a: GO:0019707 ! protein-cysteine S-acyltransferase activity

[Term]
id: GO:0019707
name: protein-cysteine S-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an acyl group to a sulfur atom on the cysteine of a protein molecule." [GOC:ai]
xref: EC:2.3.1.-
is_a: GO:0016417 ! S-acyltransferase activity

[Term]
id: GO:0019708
name: peptidyl-glycine cholesteryl ester biosynthesis from peptidyl-glycine
namespace: biological_process
def: "The synthesis of peptidyl-glycine cholest-5-en-3-beta-ol ester at the carboxy-terminus of autolytically cleaved proteins." [RESID:AA0309]
subset: gosubset_prok
synonym: "peptidyl-glycine cholesteryl ester anabolism from peptidyl-glycine" EXACT []
synonym: "peptidyl-glycine cholesteryl ester formation from peptidyl-glycine" EXACT []
synonym: "peptidyl-glycine cholesteryl ester synthesis from peptidyl-glycine" EXACT []
xref: RESID:AA0309
is_a: GO:0006501 ! C-terminal protein lipidation
is_a: GO:0008203 ! cholesterol metabolic process
is_a: GO:0018201 ! peptidyl-glycine modification
is_a: GO:0042398 ! cellular modified amino acid biosynthetic process
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0019709
name: iron incorporation into iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide
namespace: biological_process
def: "The incorporation of iron into a nickel-iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide, found in carbon monoxide dehydrogenase." [RESID:AA0310]
subset: gosubset_prok
synonym: "iron incorporation into iron-sulphur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulphide" EXACT []
xref: RESID:AA0310
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018202 ! peptidyl-histidine modification
is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0019710
name: peptidyl-asparagine methylation
namespace: biological_process
alt_id: GO:0018018
def: "The methylation of peptidyl-asparagine to form peptidyl-N4-methyl-L-asparagine or peptidyl-N4,N4-dimethyl-L-asparagine." [RESID:AA0070, RESID:AA0311]
subset: gosubset_prok
xref: RESID:AA0070
xref: RESID:AA0311
is_a: GO:0018196 ! peptidyl-asparagine modification

[Term]
id: GO:0019711
name: peptidyl-beta-carboxyaspartic acid biosynthetic process from peptidyl-aspartic acid
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of peptidyl-beta-carboxyaspartic acid from other compounds, including peptidyl-aspartic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "peptidyl-beta-carboxyaspartic acid anabolism from peptidyl-aspartic acid" EXACT []
synonym: "peptidyl-beta-carboxyaspartic acid formation from peptidyl-aspartic acid" EXACT []
synonym: "peptidyl-beta-carboxyaspartic acid synthesis from peptidyl-aspartic acid" EXACT []
is_a: GO:0018197 ! peptidyl-aspartic acid modification

[Term]
id: GO:0019712
name: peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from glutamic acid
namespace: biological_process
def: "The methyl esterification of peptidyl-glutamic acid." [RESID:AA0072]
subset: gosubset_prok
synonym: "peptidyl-L-glutamic acid 5-methyl ester anabolism from glutamic acid" EXACT []
synonym: "peptidyl-L-glutamic acid 5-methyl ester formation from glutamic acid" EXACT []
synonym: "peptidyl-L-glutamic acid 5-methyl ester synthesis from glutamic acid" EXACT []
xref: RESID:AA0072
is_a: GO:0018390 ! peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from peptidyl-glutamic acid or peptidyl-glutamine

[Term]
id: GO:0019713
name: peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from glutamine
namespace: biological_process
def: "The coupled methyl esterification and deamidation of peptidyl-glutamine." [RESID:AA0072]
subset: gosubset_prok
synonym: "peptidyl-L-glutamic acid 5-methyl ester anabolism from glutamine" EXACT []
synonym: "peptidyl-L-glutamic acid 5-methyl ester formation from glutamine" EXACT []
synonym: "peptidyl-L-glutamic acid 5-methyl ester synthesis from glutamine" EXACT []
xref: RESID:AA0072
is_a: GO:0006541 ! glutamine metabolic process
is_a: GO:0018390 ! peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from peptidyl-glutamic acid or peptidyl-glutamine
is_a: GO:0019714 ! peptidyl-glutamine esterification

[Term]
id: GO:0019714
name: peptidyl-glutamine esterification
namespace: biological_process
def: "The addition of an ester group to a glutamine residue in a protein." [GOC:mah]
subset: gosubset_prok
is_a: GO:0018199 ! peptidyl-glutamine modification
is_a: GO:0018350 ! protein esterification

[Term]
id: GO:0019715
name: peptidyl-aspartic acid hydroxylation to form L-erythro-beta-hydroxyaspartic acid
namespace: biological_process
def: "The hydroxylation of peptidyl-aspartic acid to form peptidyl-L-erythro-beta-hydroxyaspartic acid; catalyzed by peptide-aspartate beta-dioxygenase (EC:1.14.11.16)." [RESID:AA0027]
comment: See also the molecular function term 'peptide-aspartate beta-dioxygenase activity ; GO:0004597'.
subset: gosubset_prok
xref: RESID:AA0027
is_a: GO:0042264 ! peptidyl-aspartic acid hydroxylation

[Term]
id: GO:0019716
name: N-terminal peptidyl-alanine monomethylation
namespace: biological_process
def: "The monomethylation of the N-terminal alanine of proteins to form the derivative peptidyl-N-methyl-L-alanine." [RESID:AA0061]
subset: gosubset_prok
xref: RESID:AA0061
is_a: GO:0018011 ! N-terminal peptidyl-alanine methylation

[Term]
id: GO:0019717
name: obsolete synaptosome
namespace: cellular_component
def: "OBSOLETE: Any of the discrete particles (nerve-ending particles) formed from the clublike presynaptic nerve endings that resist disruption and are snapped or torn off their attachments when brain tissue is homogenized in media isosmotic to plasma." [ISBN:0198506732]
comment: This term was made obsolete because it refers to a result of cell homogenization and not a bona fide cellular component.
synonym: "synaptosome" EXACT []
xref: Wikipedia:Synaptosome
is_obsolete: true
consider: GO:0043005

[Term]
id: GO:0019718
name: obsolete rough microsome
namespace: cellular_component
def: "OBSOLETE: Vesicular particles formed from disrupted endoplasmic reticulum membranes and studded with ribosomes on the outside." [ISBN:0198506732]
comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component.
synonym: "rough microsome" EXACT []
is_obsolete: true
consider: GO:0005791

[Term]
id: GO:0019719
name: obsolete smooth microsome
namespace: cellular_component
def: "OBSOLETE: Vesicular particles formed from disrupted endoplasmic reticulum and plasma membranes without any adhering ribosomes." [ISBN:0198506732]
comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component.
synonym: "smooth microsome" EXACT []
is_obsolete: true
consider: GO:0005790

[Term]
id: GO:0019720
name: Mo-molybdopterin cofactor metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands." [http://www.sunysb.edu/biochem/BIOCHEM/facultypages/schindelin/, ISSN:09498257]
subset: gosubset_prok
synonym: "Mo-molybdopterin cofactor metabolism" EXACT []
synonym: "Moco metabolic process" BROAD []
synonym: "Moco metabolism" BROAD []
is_a: GO:0043545 ! molybdopterin cofactor metabolic process

[Term]
id: GO:0019722
name: calcium-mediated signaling
namespace: biological_process
def: "Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions." [GOC:signaling]
synonym: "calcium ion signaling" EXACT []
synonym: "calcium signaling" EXACT []
synonym: "calcium signalling" EXACT []
synonym: "calcium-mediated signalling" EXACT []
xref: Wikipedia:Calcium_signaling
is_a: GO:0019932 ! second-messenger-mediated signaling

[Term]
id: GO:0019724
name: B cell mediated immunity
namespace: biological_process
def: "Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was improved by GO_REF:0000022. It was moved.
synonym: "B lymphocyte mediated immune effector process" EXACT []
synonym: "B lymphocyte mediated immunity" EXACT []
synonym: "B-cell mediated immune effector process" EXACT []
synonym: "B-cell mediated immunity" EXACT []
synonym: "B-lymphocyte mediated immune effector process" EXACT []
synonym: "B-lymphocyte mediated immunity" EXACT []
is_a: GO:0002449 ! lymphocyte mediated immunity
is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

[Term]
id: GO:0019725
name: cellular homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state at the level of the cell." [GOC:isa_complete, GOC:jl, ISBN:0395825172]
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_plant
subset: gosubset_prok
is_a: GO:0042592 ! homeostatic process
is_a: GO:0044763 ! single-organism cellular process
intersection_of: GO:0042592 ! homeostatic process
intersection_of: occurs_in GO:0005623 ! cell
relationship: occurs_in GO:0005623 ! cell

[Term]
id: GO:0019726
name: mevaldate reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-mevalonate + NADP(+) = H(+) + mevaldate + NADPH." [EC:1.1.1.33, RHEA:20196]
synonym: "(R)-mevalonate:NADP+ oxidoreductase" EXACT [EC:1.1.1.33]
synonym: "mevaldate (reduced nicotinamide adenine dinucleotide phosphate) reductase" EXACT [EC:1.1.1.33]
xref: EC:1.1.1.33
xref: KEGG:R02247
xref: MetaCyc:MEVALDATE-REDUCTASE-NADPH-RXN
xref: RHEA:20196
is_a: GO:0004495 ! mevaldate reductase activity

[Term]
id: GO:0019727
name: mevaldate reductase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-mevalonate + NAD(+) = H(+) + mevaldate + NADH." [EC:1.1.1.32, RHEA:13224]
xref: EC:1.1.1.32
xref: KEGG:R02246
xref: MetaCyc:MEVALDATE-REDUCTASE-RXN
xref: RHEA:13224
is_a: GO:0004495 ! mevaldate reductase activity

[Term]
id: GO:0019728
name: peptidyl-allysine oxidation to 2-aminoadipic acid
namespace: biological_process
def: "The oxidation of allysine to 2-aminoadipic acid." [RESID:AA0122]
subset: gosubset_prok
xref: RESID:AA0370
is_a: GO:0018158 ! protein oxidation
is_a: GO:0018205 ! peptidyl-lysine modification

[Term]
id: GO:0019729
name: peptide cross-linking via 2-imino-glutaminyl-5-imidazolinone glycine
namespace: biological_process
def: "The formation of the fluorescent protein FP583 chromophore cross-link from the alpha-carboxyl carbon of residue n, a glutamine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons." [RESID:AA0189]
comment: See also the biological process term 'peptidyl-tyrosine dehydrogenation ; GO:0018251'.
subset: gosubset_prok
synonym: "biosynthesis of protein-protein cross-link via 2-imino-glutaminyl-5-imidazolinone glycine" EXACT []
synonym: "biosynthetic process of protein-protein cross-link via 2-imino-glutaminyl-5-imidazolinone glycine" EXACT []
xref: RESID:AA0189
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018199 ! peptidyl-glutamine modification
is_a: GO:0018201 ! peptidyl-glycine modification
is_a: GO:0018298 ! protein-chromophore linkage

[Term]
id: GO:0019730
name: antimicrobial humoral response
namespace: biological_process
alt_id: GO:0006960
alt_id: GO:0019735
def: "An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus." [GOC:go_curators, GOC:mtg_sensu]
is_a: GO:0006959 ! humoral immune response
is_a: GO:0051707 ! response to other organism

[Term]
id: GO:0019731
name: antibacterial humoral response
namespace: biological_process
alt_id: GO:0006961
alt_id: GO:0019733
def: "An immune response against bacteria mediated through a body fluid. Examples of this process are the antibacterial humoral responses in Mus musculus and Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
is_a: GO:0019730 ! antimicrobial humoral response
is_a: GO:0042742 ! defense response to bacterium

[Term]
id: GO:0019732
name: antifungal humoral response
namespace: biological_process
alt_id: GO:0006966
alt_id: GO:0019734
def: "An immune response against a fungus mediated through a body fluid. An example of this process is the antifungal humoral response in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
is_a: GO:0019730 ! antimicrobial humoral response
is_a: GO:0050832 ! defense response to fungus

[Term]
id: GO:0019736
name: peptidyl-sarcosine incorporation
namespace: biological_process
def: "The incorporation of sarcosine (N-methylglycine) into non-coded peptides." [RESID:AA0063]
subset: gosubset_prok
xref: RESID:AA0063
is_a: GO:0018201 ! peptidyl-glycine modification

[Term]
id: GO:0019740
name: nitrogen utilization
namespace: biological_process
def: "A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary nitrogen source, usually ammonia, and then activates genes to scavenge the last traces of the primary nitrogen source and to transport and metabolize alternative nitrogen sources. The utilization process begins when the cell or organism detects nitrogen levels, includes the activation of genes whose products detect, transport or metabolize nitrogen-containing substances, and ends when nitrogen is incorporated into the cell or organism's metabolism." [GOC:mah, GOC:mlg]
subset: gosubset_prok
is_a: GO:0044699 ! single-organism process
relationship: has_part GO:0006807 ! nitrogen compound metabolic process
relationship: has_part GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0019741
name: pentacyclic triterpenoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pentacyclic triterpenoid compounds, terpenoids with six isoprene units and 5 carbon rings." [ISBN:0198506732]
subset: gosubset_prok
synonym: "pentacyclic triterpenoid breakdown" EXACT []
synonym: "pentacyclic triterpenoid catabolism" EXACT []
synonym: "pentacyclic triterpenoid degradation" EXACT []
is_a: GO:0016105 ! triterpenoid catabolic process
is_a: GO:0019742 ! pentacyclic triterpenoid metabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process

[Term]
id: GO:0019742
name: pentacyclic triterpenoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pentacyclic triterpenoid compounds, terpenoids with six isoprene units and 5 carbon rings." [ISBN:0198506732]
subset: gosubset_prok
synonym: "pentacyclic triterpenoid metabolism" EXACT []
is_a: GO:0006722 ! triterpenoid metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process

[Term]
id: GO:0019743
name: hopanoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of hopanoids, pentacyclic sterol-like compounds based on the hopane nucleus." [ISBN:0198547684]
subset: gosubset_prok
synonym: "hopanoid breakdown" EXACT []
synonym: "hopanoid catabolism" EXACT []
synonym: "hopanoid degradation" EXACT []
is_a: GO:0019741 ! pentacyclic triterpenoid catabolic process
is_a: GO:0019744 ! hopanoid metabolic process

[Term]
id: GO:0019744
name: hopanoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving hopanoids, pentacyclic sterol-like compounds based on the hopane nucleus." [ISBN:0198547684]
subset: gosubset_prok
synonym: "hopanoid metabolism" EXACT []
is_a: GO:0019742 ! pentacyclic triterpenoid metabolic process

[Term]
id: GO:0019745
name: pentacyclic triterpenoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pentacyclic triterpenoid compounds, terpenoids with six isoprene units and 5 carbon rings." [ISBN:0198506732]
subset: gosubset_prok
synonym: "pentacyclic triterpenoid anabolism" EXACT []
synonym: "pentacyclic triterpenoid biosynthesis" EXACT []
synonym: "pentacyclic triterpenoid formation" EXACT []
synonym: "pentacyclic triterpenoid synthesis" EXACT []
is_a: GO:0016104 ! triterpenoid biosynthetic process
is_a: GO:0019742 ! pentacyclic triterpenoid metabolic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process

[Term]
id: GO:0019746
name: hopanoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of hopanoids, pentacyclic sterol-like compounds based on the hopane nucleus." [ISBN:0198547684]
subset: gosubset_prok
synonym: "hopanoid anabolism" EXACT []
synonym: "hopanoid biosynthesis" EXACT []
synonym: "hopanoid formation" EXACT []
synonym: "hopanoid synthesis" EXACT []
is_a: GO:0019744 ! hopanoid metabolic process
is_a: GO:0019745 ! pentacyclic triterpenoid biosynthetic process

[Term]
id: GO:0019747
name: regulation of isoprenoid metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving isoprenoids." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of isoprenoid metabolism" EXACT []
is_a: GO:0019216 ! regulation of lipid metabolic process
is_a: GO:0031323 ! regulation of cellular metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006720 ! isoprenoid metabolic process
relationship: regulates GO:0006720 ! isoprenoid metabolic process

[Term]
id: GO:0019748
name: secondary metabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients." [GOC:go_curators]
subset: goslim_aspergillus
subset: goslim_chembl
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "secondary metabolism" EXACT []
synonym: "secondary metabolite metabolic process" EXACT []
synonym: "secondary metabolite metabolism" EXACT []
xref: Wikipedia:Secondary_metabolism
is_a: GO:0044710 ! single-organism metabolic process

[Term]
id: GO:0019749
name: cytoskeleton-dependent cytoplasmic transport, nurse cell to oocyte
namespace: biological_process
def: "The directed movement of substances along cytoskeletal elements, such as microfilaments or microtubules, from a nurse cell to an oocyte." [GOC:ai]
is_a: GO:0007303 ! cytoplasmic transport, nurse cell to oocyte
is_a: GO:0030705 ! cytoskeleton-dependent intracellular transport
intersection_of: GO:0007303 ! cytoplasmic transport, nurse cell to oocyte
intersection_of: GO:0030705 ! cytoskeleton-dependent intracellular transport

[Term]
id: GO:0019750
name: chloroplast localization
namespace: biological_process
def: "Any process in which a chloroplast is transported to, and/or maintained in, a specific location within the cell. A chloroplast is a chlorophyll-containing plastid found in cells of algae and higher plants." [GOC:bf, GOC:jl, ISBN:0198506732]
synonym: "chloroplast localisation" EXACT [GOC:mah]
is_a: GO:0051644 ! plastid localization

[Term]
id: GO:0019751
name: polyol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms." [CHEBI:26191, GOC:go_curators]
subset: gosubset_prok
synonym: "polyhydric alcohol metabolic process" EXACT []
synonym: "polyol metabolism" EXACT []
is_a: GO:0006066 ! alcohol metabolic process

[Term]
id: GO:0019752
name: carboxylic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732]
subset: gosubset_prok
synonym: "carboxylic acid metabolism" EXACT []
is_a: GO:0043436 ! oxoacid metabolic process

[Term]
id: GO:0019755
name: one-carbon compound transport
namespace: biological_process
def: "The directed movement of one-carbon compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "one carbon compound transport" EXACT []
is_a: GO:0044765 ! single-organism transport
is_a: GO:0071702 ! organic substance transport

[Term]
id: GO:0019756
name: cyanogenic glycoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cyanogenic glycosides, any glycoside containing a cyano group that is released as hydrocyanic acid on acid hydrolysis; such compounds occur in the kernels of various fruits." [ISBN:0198506732]
subset: gosubset_prok
synonym: "cyanogenic glycoside anabolism" EXACT []
synonym: "cyanogenic glycoside biosynthesis" EXACT []
synonym: "cyanogenic glycoside formation" EXACT []
synonym: "cyanogenic glycoside synthesis" EXACT []
is_a: GO:0016138 ! glycoside biosynthetic process
is_a: GO:0042341 ! cyanogenic glycoside metabolic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0080028 ! nitrile biosynthetic process

[Term]
id: GO:0019757
name: glycosinolate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycosinolates, substituted thioglycosides found in rapeseed products and related cruciferae." [GOC:mah, http://www.gardeneaters.net/family_characteristics.html]
subset: gosubset_prok
synonym: "glycosinolate metabolism" EXACT []
is_a: GO:0016143 ! S-glycoside metabolic process
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0043436 ! oxoacid metabolic process

[Term]
id: GO:0019758
name: glycosinolate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycosinolates, substituted thioglycosides found in rapeseed products and related cruciferae." [GOC:mah, http://www.gardeneaters.net/family_characteristics.html]
subset: gosubset_prok
synonym: "glycosinolate anabolism" EXACT []
synonym: "glycosinolate biosynthesis" EXACT []
synonym: "glycosinolate formation" EXACT []
synonym: "glycosinolate synthesis" EXACT []
is_a: GO:0016144 ! S-glycoside biosynthetic process
is_a: GO:0019757 ! glycosinolate metabolic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process

[Term]
id: GO:0019759
name: glycosinolate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycosinolates, substituted thioglycosides found in rapeseed products and related cruciferae." [GOC:mah, http://www.gardeneaters.net/family_characteristics.html]
subset: gosubset_prok
synonym: "glycosinolate breakdown" EXACT []
synonym: "glycosinolate catabolism" EXACT []
synonym: "glycosinolate degradation" EXACT []
is_a: GO:0016145 ! S-glycoside catabolic process
is_a: GO:0019757 ! glycosinolate metabolic process

[Term]
id: GO:0019760
name: glucosinolate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae. They are metabolized to a variety of toxic products which are most likely the cause of hepatocytic necrosis in animals and humans." [CHEBI:24279, GOC:curators]
subset: gosubset_prok
synonym: "glucosinolate metabolism" EXACT []
is_a: GO:0019757 ! glycosinolate metabolic process

[Term]
id: GO:0019761
name: glucosinolate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae." [GOC:ai]
subset: gosubset_prok
synonym: "glucosinolate anabolism" EXACT []
synonym: "glucosinolate biosynthesis" EXACT []
synonym: "glucosinolate formation" EXACT []
synonym: "glucosinolate synthesis" EXACT []
is_a: GO:0019758 ! glycosinolate biosynthetic process
is_a: GO:0019760 ! glucosinolate metabolic process

[Term]
id: GO:0019762
name: glucosinolate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae." [GOC:ai]
subset: gosubset_prok
synonym: "glucosinolate breakdown" EXACT []
synonym: "glucosinolate catabolism" EXACT []
synonym: "glucosinolate degradation" EXACT []
xref: MetaCyc:PWY-5267
is_a: GO:0019759 ! glycosinolate catabolic process
is_a: GO:0019760 ! glucosinolate metabolic process

[Term]
id: GO:0019763
name: immunoglobulin receptor activity
namespace: molecular_function
alt_id: GO:0016489
def: "Combining with the Fc region of an immunoglobulin protein and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:signaling, ISBN:0198547684]
synonym: "FC receptor activity" EXACT []
is_a: GO:0004888 ! transmembrane signaling receptor activity
relationship: has_part GO:0019865 ! immunoglobulin binding
relationship: part_of GO:0038093 ! Fc receptor signaling pathway

[Term]
id: GO:0019764
name: obsolete high affinity Fc receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:add]
comment: This term was made obsolete because it is an unnecessary grouping term.
synonym: "high affinity Fc receptor activity" EXACT []
is_obsolete: true
consider: GO:0019768
consider: GO:0019771

[Term]
id: GO:0019765
name: obsolete low affinity Fc receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:add]
comment: This term was made obsolete because it is undefined and is an unnecessary grouping term.
synonym: "low affinity Fc receptor activity" EXACT []
is_obsolete: true
consider: GO:0019769
consider: GO:0019772

[Term]
id: GO:0019766
name: IgA receptor activity
namespace: molecular_function
def: "Combining with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]
is_a: GO:0019763 ! immunoglobulin receptor activity
relationship: has_part GO:0019862 ! IgA binding

[Term]
id: GO:0019767
name: IgE receptor activity
namespace: molecular_function
def: "Combining with an immunoglobulin of the IgE isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]
is_a: GO:0019763 ! immunoglobulin receptor activity
relationship: has_part GO:0019863 ! IgE binding
relationship: part_of GO:0038095 ! Fc-epsilon receptor signaling pathway

[Term]
id: GO:0019768
name: high-affinity IgE receptor activity
namespace: molecular_function
def: "Combining with high affinity with an immunoglobulin of the IgE isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]
synonym: "high affinity Fc receptor activity" RELATED []
synonym: "high affinity IgE receptor activity" EXACT []
is_a: GO:0019767 ! IgE receptor activity

[Term]
id: GO:0019769
name: low-affinity IgE receptor activity
namespace: molecular_function
def: "Combining with low affinity with an immunoglobulin of the IgE isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]
synonym: "low affinity Fc receptor activity" RELATED []
synonym: "low affinity IgE receptor activity" EXACT []
is_a: GO:0019767 ! IgE receptor activity

[Term]
id: GO:0019770
name: IgG receptor activity
namespace: molecular_function
def: "Combining with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]
is_a: GO:0019763 ! immunoglobulin receptor activity
relationship: has_part GO:0019864 ! IgG binding
relationship: part_of GO:0038094 ! Fc-gamma receptor signaling pathway

[Term]
id: GO:0019771
name: high-affinity IgG receptor activity
namespace: molecular_function
def: "Combining with high affinity with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]
synonym: "high affinity Fc receptor activity" RELATED []
synonym: "high affinity IgG receptor activity" EXACT []
is_a: GO:0019770 ! IgG receptor activity

[Term]
id: GO:0019772
name: low-affinity IgG receptor activity
namespace: molecular_function
def: "Combining with low affinity with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]
synonym: "low affinity Fc receptor activity" RELATED []
synonym: "low affinity IgG receptor activity" EXACT []
is_a: GO:0019770 ! IgG receptor activity

[Term]
id: GO:0019773
name: proteasome core complex, alpha-subunit complex
namespace: cellular_component
def: "The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus." [GOC:jl, GOC:mtg_sensu, GOC:rb, PMID:10854779]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0005839 ! proteasome core complex

[Term]
id: GO:0019774
name: proteasome core complex, beta-subunit complex
namespace: cellular_component
def: "The proteasome core subcomplex that constitutes the two inner rings of the proteasome core complex. An example of this component is found in Mus musculus." [GOC:jl, GOC:mtg_sensu, GOC:rb, PMID:10854779]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0005839 ! proteasome core complex

[Term]
id: GO:0019775
name: FAT10 transferase activity
namespace: molecular_function
def: "Catalysis of the transfer of FAT10 from one protein to another via the reaction X-FAT10 + Y --> Y-FAT10 + X, where both X-FAT10 and Y-FAT10 are covalent linkages." [GOC:dph, GOC:mah, PMID:12826404]
synonym: "FAT10 conjugating enzyme activity" NARROW []
is_a: GO:0019787 ! ubiquitin-like protein transferase activity

[Term]
id: GO:0019776
name: Atg8 ligase activity
namespace: molecular_function
def: "Catalysis of the covalent attachment of the ubiquitin-like protein Atg8 to substrate molecules; phosphatidylethanolamine is a known substrate." [GOC:mah, PMID:12826404]
synonym: "APG8 conjugating enzyme activity" EXACT []
synonym: "APG8 ligase activity" EXACT []
synonym: "Atg8 conjugating enzyme activity" EXACT []
is_a: GO:0016740 ! transferase activity

[Term]
id: GO:0019777
name: Atg12 transferase activity
namespace: molecular_function
def: "Catalysis of the transfer of ATG12 from one protein to another via the reaction X-ATG12 + Y --> Y-ATG12 + X, where both X-ATG12 and Y-ATG12 are covalent linkages." [GOC:mah, PMID:12826404]
synonym: "APG12 conjugating enzyme activity" NARROW []
synonym: "APG12 ligase activity" NARROW []
synonym: "Atg12 conjugating enzyme activity" NARROW []
synonym: "Atg12 ligase activity" NARROW []
is_a: GO:0019787 ! ubiquitin-like protein transferase activity

[Term]
id: GO:0019778
name: Atg12 activating enzyme activity
namespace: molecular_function
def: "Catalysis of the activation of the small ubiquitin-related modifier APG12, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah]
synonym: "APG12 activating enzyme activity" RELATED [GOC:vw]
is_a: GO:0008641 ! small protein activating enzyme activity

[Term]
id: GO:0019779
name: Atg8 activating enzyme activity
namespace: molecular_function
def: "Catalysis of the activation of the small ubiquitin-related modifier APG8, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah]
synonym: "APG7" EXACT []
synonym: "APG8 activating enzyme activity" RELATED [GOC:vw]
is_a: GO:0008641 ! small protein activating enzyme activity

[Term]
id: GO:0019780
name: FAT10 activating enzyme activity
namespace: molecular_function
def: "Catalysis of the activation of the small ubiquitin-related modifier FAT10, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah]
is_a: GO:0008641 ! small protein activating enzyme activity

[Term]
id: GO:0019781
name: NEDD8 activating enzyme activity
namespace: molecular_function
alt_id: GO:0019944
def: "Catalysis of the initiation of the NEDD8 (RUB1) conjugation cascade." [PMID:12646924]
synonym: "RUB1 activating enzyme activity" EXACT []
is_a: GO:0008641 ! small protein activating enzyme activity

[Term]
id: GO:0019782
name: ISG15 activating enzyme activity
namespace: molecular_function
def: "Catalysis of the activation of the small ubiquitin-related modifier ISG15, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah]
synonym: "UBE1L" NARROW []
is_a: GO:0008641 ! small protein activating enzyme activity

[Term]
id: GO:0019783
name: ubiquitin-like protein-specific protease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of peptide or isopeptide bonds within small proteins such as ubiquitin or ubiquitin-like proteins (e.g. APG8, ISG15, NEDD8, SUMO), or between the small protein and a larger protein to which it has been conjugated." [GOC:ma, GOC:mah]
subset: gosubset_prok
synonym: "small conjugating protein-specific protease activity" EXACT [GOC:dph]
synonym: "ubiquitin-like specific protease activity" NARROW []
synonym: "ubiquitin-like-protein-specific protease activity" NARROW []
is_a: GO:0008234 ! cysteine-type peptidase activity

[Term]
id: GO:0019784
name: NEDD8-specific protease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of NEDD8, a small ubiquitin-related modifier, from previously neddylated substrates." [GOC:mah]
synonym: "deneddylase activity" EXACT [GOC:dph]
is_a: GO:0019783 ! ubiquitin-like protein-specific protease activity

[Term]
id: GO:0019785
name: ISG15-specific protease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of ISG15, a small ubiquitin-related modifier, from previously modified substrates." [GOC:mah]
xref: Reactome:REACT_115684 "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18, Homo sapiens"
is_a: GO:0019783 ! ubiquitin-like protein-specific protease activity

[Term]
id: GO:0019786
name: Atg8-specific protease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of APG8, a small ubiquitin-related modifier." [GOC:mah]
synonym: "APG8-PE hydrolase" RELATED []
synonym: "APG8-specific protease activity" RELATED [GOC:vw]
is_a: GO:0019783 ! ubiquitin-like protein-specific protease activity

[Term]
id: GO:0019787
name: ubiquitin-like protein transferase activity
namespace: molecular_function
alt_id: GO:0008639
alt_id: GO:0008640
def: "Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y --> Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein." [GOC:mah, GOC:rn, PMID:10806345, PMID:10884686]
subset: gosubset_prok
synonym: "E2" RELATED []
synonym: "E3" RELATED [dph:GOC]
synonym: "small conjugating protein ligase activity" NARROW [GOC:dph]
synonym: "small conjugating protein transferase activity" EXACT [GOC:dph]
synonym: "small protein conjugating enzyme activity" NARROW []
synonym: "ubiquitin-like conjugating enzyme activity" NARROW []
synonym: "ubiquitin-like-protein ligase activity" NARROW []
xref: Reactome:REACT_75843 "RIP2 is K63 polyubiquitinated, Homo sapiens"
is_a: GO:0016740 ! transferase activity

[Term]
id: GO:0019788
name: NEDD8 transferase activity
namespace: molecular_function
alt_id: GO:0016976
alt_id: GO:0019945
alt_id: GO:0042295
def: "Catalysis of the transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y --> Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages." [GOC:mah]
synonym: "Hub1 conjugating enzyme activity" RELATED []
synonym: "NEDD8 conjugating enzyme activity" RELATED []
synonym: "RUB1 conjugating enzyme activity" RELATED []
is_a: GO:0019787 ! ubiquitin-like protein transferase activity

[Term]
id: GO:0019789
name: SUMO transferase activity
namespace: molecular_function
alt_id: GO:0016930
alt_id: GO:0019949
def: "Catalysis of the transfer of SUMO from one protein to another via the reaction X-SUMO + Y --> Y-SUMO + X, where both X-SUMO and Y-SUMO are covalent linkages." [GOC:rn, PMID:11031248, PMID:11265250]
synonym: "SMT3 conjugating enzyme" RELATED []
synonym: "SUMO conjugating enzyme activity" RELATED []
is_a: GO:0019787 ! ubiquitin-like protein transferase activity

[Term]
id: GO:0019790
name: obsolete ubiquitin-like hydrolase activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it cannot be determined what its intended meaning was, because the term name is not found in the literature.
synonym: "ubiquitin-like hydrolase activity" EXACT []
is_obsolete: true
consider: GO:0019783

[Term]
id: GO:0019791
name: obsolete FAT10 hydrolase activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it cannot be determined what its intended meaning was, because the term name is not found in the literature.
synonym: "FAT10 hydrolase activity" EXACT []
is_obsolete: true
consider: GO:0019783

[Term]
id: GO:0019792
name: obsolete APG12 hydrolase activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it cannot be determined what its intended meaning was, because the term name is not found in the literature.
synonym: "APG12 hydrolase activity" EXACT []
is_obsolete: true
consider: GO:0019783

[Term]
id: GO:0019793
name: obsolete ISG15 carrier activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the transfer of ISG15 (interferon-stimulated gene-15) from one side of the membrane to the other." [GOC:jl, http://www.copewithcytokines.de/]
comment: This term was made obsolete because it is gene product-specific and has no annotations.
synonym: "interferon-stimulated gene-15 carrier activity" NARROW []
synonym: "ISG15 carrier activity" EXACT []
is_obsolete: true

[Term]
id: GO:0019794
name: obsolete nonprotein amino acid metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving any amino acid not found, or rarely found, in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]
comment: This term was made obsolete because it was a grouping term that was poorly defined and did not provide a particularly meaningful grouping, since even for those amino acids commonly found in proteins, not all molecules necessarily end up incorporated into proteins. The term also violated the principle of positivity.
subset: gosubset_prok
synonym: "nonprotein amino acid metabolic process" EXACT []
synonym: "nonprotein amino acid metabolism" EXACT []
is_obsolete: true
replaced_by: GO:0006520

[Term]
id: GO:0019795
name: obsolete nonprotein amino acid biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of any amino acid that does not normally occur as a constituent residue of proteins." [GOC:ma]
comment: This term was made obsolete because it was a grouping term that was poorly defined and did not provide a particularly meaningful grouping, since even for those amino acids commonly found in proteins, not all molecules necessarily end up incorporated into proteins. The term also violated the principle of positivity.
subset: gosubset_prok
synonym: "nonprotein amino acid anabolism" EXACT []
synonym: "nonprotein amino acid biosynthesis" EXACT []
synonym: "nonprotein amino acid biosynthetic process" EXACT []
synonym: "nonprotein amino acid formation" EXACT []
synonym: "nonprotein amino acid synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0008652

[Term]
id: GO:0019796
name: obsolete nonprotein amino acid catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of any amino acid not found, or rarely found, in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]
comment: This term was made obsolete because it was a grouping term that was poorly defined and did not provide a particularly meaningful grouping, since even for those amino acids commonly found in proteins, not all molecules necessarily end up incorporated into proteins. The term also violated the principle of positivity.
subset: gosubset_prok
synonym: "nonprotein amino acid breakdown" EXACT []
synonym: "nonprotein amino acid catabolic process" EXACT []
synonym: "nonprotein amino acid catabolism" EXACT []
synonym: "nonprotein amino acid degradation" EXACT []
is_obsolete: true
replaced_by: GO:0009063

[Term]
id: GO:0019797
name: procollagen-proline 3-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-3-hydroxy-L-proline + succinate + CO2." [EC:1.14.11.7]
synonym: "procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.11.7]
synonym: "procollagen-proline,2-oxoglutarate 3-dioxygenase activity" EXACT [EC:1.14.11.7]
synonym: "proline,2-oxoglutarate 3-dioxygenase activity" EXACT [EC:1.14.11.7]
synonym: "prolyl 3-hydroxylase activity" BROAD [EC:1.14.11.7]
synonym: "prolyl-4-hydroxyprolyl-glycyl-peptide, 2-oxoglutarate: oxygen oxidoreductase, 3-hydroxylating activity" EXACT [EC:1.14.11.7]
synonym: "protocollagen proline 3-hydroxylase activity" EXACT [EC:1.14.11.7]
xref: EC:1.14.11.7
xref: KEGG:R03218
xref: MetaCyc:PROCOLLAGEN-PROLINE-3-DIOXYGENASE-RXN
is_a: GO:0019798 ! procollagen-proline dioxygenase activity
is_a: GO:0031544 ! peptidyl-proline 3-dioxygenase activity

[Term]
id: GO:0019798
name: procollagen-proline dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-hydroxy-L-proline + succinate + CO2." [EC:1.14.11.2, EC:1.14.11.7, GOC:mah]
xref: EC:1.14.11.-
is_a: GO:0031543 ! peptidyl-proline dioxygenase activity

[Term]
id: GO:0019799
name: tubulin N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + (alpha-tubulin) L-lysine = CoA + (alpha-tubulin) N6-acetyl-L-lysine." [EC:2.3.1.108]
synonym: "acetyl-CoA:alpha-tubulin-L-lysine 6-N-acetyltransferase activity" EXACT [EC:2.3.1.108]
synonym: "acetyl-CoA:alpha-tubulin-L-lysine N6-acetyltransferase activity" EXACT [EC:2.3.1.108]
synonym: "acetyl-CoA:alpha-tubulin-lysine N-acetyltransferase activity" EXACT [EC:2.3.1.108]
synonym: "alpha-tubulin acetylase activity" EXACT [EC:2.3.1.108]
synonym: "alpha-tubulin acetyltransferase activity" EXACT [EC:2.3.1.108]
synonym: "alpha-tubulin N-acetyltransferase activity" EXACT [EC:2.3.1.108]
synonym: "TAT activity" EXACT [EC:2.3.1.108]
synonym: "tubulin acetyltransferase activity" EXACT [EC:2.3.1.108]
xref: EC:2.3.1.108
xref: MetaCyc:TUBULIN-N-ACETYLTRANSFERASE-RXN
is_a: GO:0061733 ! peptide-lysine-N-acetyltransferase activity

[Term]
id: GO:0019800
name: peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan
namespace: biological_process
def: "The formation of a cross-link between peptide chains mediated by a chondroitin 4-sulfate glycosaminoglycan that originates from a typical O-glycosidic link to serine of one chain; the other chain is esterified, via the alpha-carbon of its C-terminal Asp, to C-6 of an internal N-acetylgalactosamine of the glycosaminoglycan chain." [PMID:1898736, RESID:AA0219]
subset: gosubset_prok
synonym: "peptide cross-linking via chondroitin 4-sulphate glycosaminoglycan" EXACT []
xref: RESID:AA0219
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018209 ! peptidyl-serine modification
is_a: GO:0030204 ! chondroitin sulfate metabolic process

[Term]
id: GO:0019801
name: cyclization of asparagine involved in intein-mediated protein splicing
namespace: biological_process
def: "The cyclization of asparagine to yield an L-aspartimide (otherwise known as alpha-aminosuccinimide) residue at the C-terminus of an excised intein during protein splicing." [RESID:AA0302]
comment: See also the biological process term 'intein-mediated protein splicing ; GO:0016539'.
subset: gosubset_prok
synonym: "cyclization of asparagine, during protein splicing" RELATED [GOC:dph, GOC:tb]
xref: RESID:AA0302
is_a: GO:0006528 ! asparagine metabolic process
relationship: part_of GO:0016539 ! intein-mediated protein splicing

[Term]
id: GO:0019802
name: cyclization of glutamine involved in intein-mediated protein splicing
namespace: biological_process
def: "The cyclization of glutamine to yield an L-glutamimide residue at the C-terminus of an excised intein during protein splicing." [GOC:dph, GOC:tb, RESID:AA0303]
comment: Note that this term should not be confused with 'peptidyl-pyroglutamic acid biosynthesis, using glutaminyl-peptide cyclotransferase ; GO:0017186'. See also the biological process term 'intein-mediated protein splicing ; GO:0016539'.
subset: gosubset_prok
synonym: "cyclization of glutamine, during protein splicing" RELATED [GOC:dph, GOC:tb]
xref: RESID:AA0303
is_a: GO:0006541 ! glutamine metabolic process
relationship: part_of GO:0016539 ! intein-mediated protein splicing

[Term]
id: GO:0019803
name: peptidyl-aspartic acid carboxylation
namespace: biological_process
def: "The carboxylation of peptidyl-aspartic acid to form peptidyl-L-beta-carboxyaspartic acid." [RESID:AA0304]
subset: gosubset_prok
xref: RESID:AA0304
is_a: GO:0018197 ! peptidyl-aspartic acid modification
is_a: GO:0018214 ! protein carboxylation

[Term]
id: GO:0019804
name: obsolete quinolinate synthetase complex
namespace: cellular_component
def: "OBSOLETE. A heterodimer which acts as a quinolinate synthetase; quinolinate synthetase B (L-aspartate oxidase) catalyzes the oxidation of L-aspartate to L-iminoaspartate; quinolinate synthetase A condenses L-imidoaspartate and dihydroxyacetone to quinolinate." [UniProtKB:P10902]
comment: This term was made obsolete because there is no evidence that a physical complex forms; although the phrase "quinolinate synthetase complex" is occasionally used in the literature, it refers to two enzymes that act as monomers.
synonym: "quinolinate synthetase complex" EXACT []
is_obsolete: true
consider: GO:0008743
consider: GO:0008987

[Term]
id: GO:0019805
name: quinolinate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid." [GOC:ai]
subset: gosubset_prok
synonym: "quinolinate anabolism" EXACT []
synonym: "quinolinate biosynthesis" EXACT []
synonym: "quinolinate formation" EXACT []
synonym: "quinolinate synthesis" EXACT []
is_a: GO:0043650 ! dicarboxylic acid biosynthetic process
is_a: GO:0046874 ! quinolinate metabolic process
is_a: GO:0072525 ! pyridine-containing compound biosynthetic process

[Term]
id: GO:0019806
name: bromide peroxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 R-H + 2 bromide + hydrogen peroxide = 2 R-Br + 2 H2O. Enzymes with this activity often accept other halide ions as substrates, including chloride and iodide." [EC:1.11.1.10]
subset: gosubset_prok
synonym: "bromoperoxidase activity" EXACT []
xref: EC:1.11.1.-
is_a: GO:0004601 ! peroxidase activity

[Term]
id: GO:0019807
name: aspartoacylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acyl-L-aspartate + H2O = a fatty acid anion + L-aspartate." [EC:3.5.1.15]
subset: gosubset_prok
synonym: "acetyl-aspartic deaminase activity" EXACT [EC:3.5.1.15]
synonym: "acylase II" RELATED [EC:3.5.1.15]
synonym: "aminoacylase II activity" RELATED [EC:3.5.1.15]
synonym: "N-acetylaspartate amidohydrolase activity" EXACT [EC:3.5.1.15]
synonym: "N-acyl-L-aspartate amidohydrolase activity" EXACT [EC:3.5.1.15]
xref: EC:3.5.1.15
xref: MetaCyc:ASPARTOACYLASE-RXN
xref: RHEA:10875
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0019808
name: polyamine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with polyamines, organic compounds containing two or more amino groups." [GOC:ai]
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0019809
name: spermidine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:ai]
is_a: GO:0019808 ! polyamine binding
is_a: GO:0070405 ! ammonium ion binding

[Term]
id: GO:0019810
name: putrescine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with putrescine, 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine." [GOC:ai]
is_a: GO:0019808 ! polyamine binding
is_a: GO:0070405 ! ammonium ion binding

[Term]
id: GO:0019811
name: cocaine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with cocaine (2-beta-carbomethoxy-3-beta-benzoxytropane), an alkaloid obtained from dried leaves of the South American shrub Erythroxylon coca or by chemical synthesis." [GOC:jl, ISBN:0198506732]
is_a: GO:0008144 ! drug binding
is_a: GO:0070405 ! ammonium ion binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding

[Term]
id: GO:0019812
name: Type I site-specific deoxyribonuclease complex
namespace: cellular_component
def: "A multisubunit complex composed of two copies of a restriction (R) subunit, two copies of a methylation (M) subunit, and one copy of a specificity (S) subunit. This complex recognizes specific short DNA sequences (through the S subunit), and binds to them. If the recognition site is hemimethylated, the complex acts as a methyltransferase which modifies the recognition site, using S-adenosylmethionine as the methyl donor. Only the M and S subunits are required for this reaction. If the complex binds to an unmethylated recognition site, then the complex translocates the DNA bidirectionally in an ATP-dependent manner. When the translocation is stalled by impact with another complex or unusual DNA structure, the enzyme functions as an endonuclease and cleavage of the DNA will occur, hundreds or thousands of base pairs away from the recognition site. These DNA restriction systems are used by bacteria to defend against phage and other foreign DNA that may enter a cell." [PMID:12654995, PMID:15788748]
subset: gosubset_prok
synonym: "Type I restriction enzyme complex" EXACT []
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0019813
name: Type III site-specific deoxyribonuclease complex
namespace: cellular_component
def: "A heterodimeric enzyme complex composed of two subunits, Res and Mod, that functions as an endonuclease and cleaves DNA. Cleavage will only occur when there are two un-methylated copies of a specific recognition site in an inverse orientation on the DNA. Cleavage occurs at a specific distance away from one of the recognition sites. The Mod subunit can act alone as a methyltansferase. DNA restriction systems such as this are used by bacteria to defend against phage and other foreign DNA that may enter a cell." [PMID:12654995]
subset: gosubset_prok
synonym: "Type III restriction enzyme complex" EXACT []
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0019814
name: immunoglobulin complex
namespace: cellular_component
def: "A protein complex that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains, held together by disulfide bonds and sometimes complexed with additional proteins. An immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, GOC:jl, ISBN:0781765196]
comment: Note that an immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
subset: goslim_pir
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0019815
name: B cell receptor complex
namespace: cellular_component
alt_id: GO:0042570
def: "An immunoglobulin complex that is present in the plasma membrane of B cells and that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [GOC:add, ISBN:0781735149]
comment: Note that an immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
synonym: "antibody" RELATED [GOC:mah]
synonym: "B cell receptor accessory molecule complex" RELATED []
synonym: "B lymphocyte receptor complex" EXACT []
synonym: "B-cell receptor complex" EXACT []
synonym: "B-lymphocyte receptor complex" EXACT []
synonym: "BCR complex" EXACT []
synonym: "immunoglobulin complex, membrane bound" EXACT []
is_a: GO:0019814 ! immunoglobulin complex
is_a: GO:0098802 ! plasma membrane receptor complex

[Term]
id: GO:0019816
name: obsolete B cell receptor accessory molecule complex
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a molecule and not a location or complex.
synonym: "B cell receptor accessory molecule complex" EXACT []
is_obsolete: true
consider: GO:0019815

[Term]
id: GO:0019817
name: vesicle fusion with peroxisome
namespace: biological_process
def: "The joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the peroxisome." [GOC:jid]
is_a: GO:0006906 ! vesicle fusion
relationship: part_of GO:0007031 ! peroxisome organization

[Term]
id: GO:0019819
name: P1 peroxisome
namespace: cellular_component
def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P1 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content; they contain fewer peroxisomal proteins than the other subforms." [PMID:10629216]
comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P2 peroxisome ; GO:0019820', 'P3 peroxisome ; GO:0019821', 'P4 peroxisome ; GO:0019822', 'P5 peroxisome ; GO:0019823', and 'P6 peroxisome ; GO:0019824'.
synonym: "peroxisome vesicle" BROAD []
is_a: GO:0005777 ! peroxisome

[Term]
id: GO:0019820
name: P2 peroxisome
namespace: cellular_component
def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P2 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content; they are the least dense of the subforms observed." [PMID:10629216]
comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P3 peroxisome ; GO:0019821', 'P4 peroxisome ; GO:0019822', 'P5 peroxisome ; GO:0019823', and 'P6 peroxisome ; GO:0019824'.
synonym: "peroxisome vesicle" BROAD []
is_a: GO:0005777 ! peroxisome

[Term]
id: GO:0019821
name: P3 peroxisome
namespace: cellular_component
def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P3 peroxisomes are formed by fusion of P1 and P2 peroxisomes, and are distinguished from the other subforms on the bases of buoyant density and protein content." [PMID:10629216]
comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P2 peroxisome ; GO:0019820', 'P4 peroxisome ; GO:0019822', 'P5 peroxisome ; GO:0019823', and 'P6 peroxisome ; GO:0019824'.
synonym: "peroxisome vesicle" BROAD []
is_a: GO:0005777 ! peroxisome

[Term]
id: GO:0019822
name: P4 peroxisome
namespace: cellular_component
def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P4 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content." [PMID:10629216]
comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P2 peroxisome ; GO:0019820', 'P3 peroxisome ; GO:0019821', 'P5 peroxisome ; GO:0019823', and 'P6 peroxisome ; GO:0019824'.
synonym: "peroxisome vesicle" BROAD []
is_a: GO:0005777 ! peroxisome

[Term]
id: GO:0019823
name: P5 peroxisome
namespace: cellular_component
def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P5 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content." [PMID:10629216]
comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P2 peroxisome ; GO:0019820', 'P3 peroxisome ; GO:0019821', 'P4 peroxisome ; GO:0019822', and 'P6 peroxisome ; GO:0019824'.
synonym: "peroxisome vesicle" BROAD []
is_a: GO:0005777 ! peroxisome

[Term]
id: GO:0019824
name: P6 peroxisome
namespace: cellular_component
def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P6 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content, and are equivalent to mature peroxisomes." [PMID:10629216]
comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P2 peroxisome ; GO:0019820', 'P3 peroxisome ; GO:0019821', 'P4 peroxisome ; GO:0019822', and 'P5 peroxisome ; GO:0019823'.
synonym: "peroxisome vesicle" BROAD []
is_a: GO:0005777 ! peroxisome

[Term]
id: GO:0019825
name: oxygen binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with oxygen (O2)." [GOC:jl]
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "cytochrome P450" NARROW []
synonym: "cytochrome P450 activity" RELATED []
xref: Reactome:REACT_100179 "Cyclophosphamide is 4-hydroxylated by CYP2B6, Mus musculus"
xref: Reactome:REACT_100188 "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI), Danio rerio"
xref: Reactome:REACT_100232 "CYP4B1 can 12-hydroxylate arachidonic acid, Xenopus tropicalis"
xref: Reactome:REACT_100276 "Dehalogenation of carbon tetrachloride to form a free radical, Mus musculus"
xref: Reactome:REACT_100352 "CYP2F1 dehydrogenates 3-methylindole, Sus scrofa"
xref: Reactome:REACT_100647 "N-atom dealkylation of caffeine, Bos taurus"
xref: Reactome:REACT_100686 "CYP4B1 can 12-hydroxylate arachidonic acid, Gallus gallus"
xref: Reactome:REACT_100861 "CYP4B1 can 12-hydroxylate arachidonic acid, Sus scrofa"
xref: Reactome:REACT_100981 "N-hydroxylation of 4-aminobiphenyl, Taeniopygia guttata"
xref: Reactome:REACT_101073 "N-atom dealkylation of caffeine, Taeniopygia guttata"
xref: Reactome:REACT_101109 "CYP1B1 4-hydroxylates estradiol-17beta, Canis familiaris"
xref: Reactome:REACT_101424 "MEOS oxidizes ethanol to acetaldehyde, Bos taurus"
xref: Reactome:REACT_101610 "CYP2C19 5-hydroxylates omeprazole, Rattus norvegicus"
xref: Reactome:REACT_101735 "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation, Taeniopygia guttata"
xref: Reactome:REACT_102272 "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation, Bos taurus"
xref: Reactome:REACT_102377 "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide, Sus scrofa"
xref: Reactome:REACT_102634 "Cyclophosphamide is 4-hydroxylated by CYP2B6, Sus scrofa"
xref: Reactome:REACT_102704 "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation, Mus musculus"
xref: Reactome:REACT_102736 "S-atom dealkylation of 6-methylmercaptopurine, Sus scrofa"
xref: Reactome:REACT_103035 "Ethylene is oxidized to Ethylene oxide by CYP1A1, Canis familiaris"
xref: Reactome:REACT_103579 "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide, Rattus norvegicus"
xref: Reactome:REACT_103850 "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation, Sus scrofa"
xref: Reactome:REACT_103936 "CYP4F12 hydroxylates arachidonic acid, Taeniopygia guttata"
xref: Reactome:REACT_104062 "Vinyl chloride is oxidized to 2-Chloroethylene oxide, Rattus norvegicus"
xref: Reactome:REACT_104186 "Cyclophosphamide is 4-hydroxylated by CYP2B6, Xenopus tropicalis"
xref: Reactome:REACT_104401 "CYP4B1 can 12-hydroxylate arachidonic acid, Danio rerio"
xref: Reactome:REACT_104682 "CYP4F12 hydroxylates arachidonic acid, Mus musculus"
xref: Reactome:REACT_104739 "Cyclophosphamide is 4-hydroxylated by CYP2B6, Danio rerio"
xref: Reactome:REACT_105445 "CYP3A4 can N-demethylate loperaminde, Drosophila melanogaster"
xref: Reactome:REACT_105726 "Benzene is hydroxylated to phenol, Taeniopygia guttata"
xref: Reactome:REACT_106173 "N-atom dealkylation of caffeine, Sus scrofa"
xref: Reactome:REACT_106332 "CYP2U1 can omega-hydroxylate arachidonate, Rattus norvegicus"
xref: Reactome:REACT_106588 "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI), Canis familiaris"
xref: Reactome:REACT_106593 "CYP4F8 hydroxylates prostaglandin H2, Danio rerio"
xref: Reactome:REACT_106741 "CYP2C19 5-hydroxylates omeprazole, Mus musculus"
xref: Reactome:REACT_106777 "Cyclophosphamide is 4-hydroxylated by CYP2B6, Canis familiaris"
xref: Reactome:REACT_106979 "Ethylene is oxidized to Ethylene oxide by CYP1A1, Taeniopygia guttata"
xref: Reactome:REACT_107183 "CYP2U1 can omega-hydroxylate arachidonate, Canis familiaris"
xref: Reactome:REACT_107350 "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation, Taeniopygia guttata"
xref: Reactome:REACT_107408 "CYP2C19 5-hydroxylates omeprazole, Sus scrofa"
xref: Reactome:REACT_107478 "MEOS oxidizes ethanol to acetaldehyde, Danio rerio"
xref: Reactome:REACT_107548 "N-hydroxylation of 4-aminobiphenyl, Rattus norvegicus"
xref: Reactome:REACT_107861 "CYP2U1 can omega-hydroxylate arachidonate, Taeniopygia guttata"
xref: Reactome:REACT_107973 "CYP2C19 5-hydroxylates omeprazole, Gallus gallus"
xref: Reactome:REACT_108050 "Benzene is hydroxylated to phenol, Gallus gallus"
xref: Reactome:REACT_108219 "N-hydroxylation of 4-aminobiphenyl, Mus musculus"
xref: Reactome:REACT_108341 "N-atom dealkylation of caffeine, Mus musculus"
xref: Reactome:REACT_108385 "Dehalogenation of carbon tetrachloride to form a free radical, Danio rerio"
xref: Reactome:REACT_108547 "Vinyl chloride is oxidized to 2-Chloroethylene oxide, Danio rerio"
xref: Reactome:REACT_108912 "Benzene is hydroxylated to phenol, Canis familiaris"
xref: Reactome:REACT_108924 "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide, Gallus gallus"
xref: Reactome:REACT_109005 "CYP2F1 dehydrogenates 3-methylindole, Danio rerio"
xref: Reactome:REACT_109209 "MEOS oxidizes ethanol to acetaldehyde, Gallus gallus"
xref: Reactome:REACT_109592 "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI), Taeniopygia guttata"
xref: Reactome:REACT_109788 "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation, Rattus norvegicus"
xref: Reactome:REACT_110347 "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI), Gallus gallus"
xref: Reactome:REACT_110759 "CYP3A5 oxidises aflatoxin B1 to aflatoxin-8,9-oxide, Mus musculus"
xref: Reactome:REACT_112032 "CYP3A4 can N-demethylate loperaminde, Taeniopygia guttata"
xref: Reactome:REACT_112331 "S-atom dealkylation of 6-methylmercaptopurine, Danio rerio"
xref: Reactome:REACT_112347 "N-atom dealkylation of caffeine, Danio rerio"
xref: Reactome:REACT_112584 "S-atom dealkylation of 6-methylmercaptopurine, Gallus gallus"
xref: Reactome:REACT_112653 "Ethylene is oxidized to Ethylene oxide by CYP1A1, Gallus gallus"
xref: Reactome:REACT_112751 "CYP1B1 4-hydroxylates estradiol-17beta, Danio rerio"
xref: Reactome:REACT_112900 "N-atom dealkylation of caffeine, Gallus gallus"
xref: Reactome:REACT_113220 "CYP3A5 oxidises aflatoxin B1 to aflatoxin-8,9-oxide, Taeniopygia guttata"
xref: Reactome:REACT_113292 "N-hydroxylation of 4-aminobiphenyl, Danio rerio"
xref: Reactome:REACT_113841 "Ethylene is oxidized to Ethylene oxide by CYP1A1, Danio rerio"
xref: Reactome:REACT_114039 "N-hydroxylation of 4-aminobiphenyl, Gallus gallus"
xref: Reactome:REACT_114317 "CYP3A7 can 6beta-hydroxylate testosterone, Taeniopygia guttata"
xref: Reactome:REACT_1165 "N-atom dealkylation of caffeine, Homo sapiens"
xref: Reactome:REACT_122 "Dehalogenation of carbon tetrachloride to form a free radical, Homo sapiens"
xref: Reactome:REACT_13412 "CYP2U1 can omega-hydroxylate arachidonate, Homo sapiens"
xref: Reactome:REACT_13485 "CYP4F12 hydroxylates arachidonic acid, Homo sapiens"
xref: Reactome:REACT_13515 "Cyclophosphamide is 4-hydroxylated by CYP2B6, Homo sapiens"
xref: Reactome:REACT_13607 "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation, Homo sapiens"
xref: Reactome:REACT_13614 "CYP4F3 omega-hydroxylates leukotriene B4, thus inactivating it, Homo sapiens"
xref: Reactome:REACT_13615 "CYP4B1 can 12-hydroxylate arachidonic acid, Homo sapiens"
xref: Reactome:REACT_13624 "CYP4F8 hydroxylates prostaglandin H2, Homo sapiens"
xref: Reactome:REACT_13651 "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation, Homo sapiens"
xref: Reactome:REACT_13668 "CYP1B1 4-hydroxylates estradiol-17beta, Homo sapiens"
xref: Reactome:REACT_13670 "CYP3A7 can 6beta-hydroxylate testosterone, Homo sapiens"
xref: Reactome:REACT_13671 "CYP2F1 dehydrogenates 3-methylindole, Homo sapiens"
xref: Reactome:REACT_13729 "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation, Homo sapiens"
xref: Reactome:REACT_13734 "CYP3A5 oxidises aflatoxin B1 to aflatoxin-8,9-oxide, Homo sapiens"
xref: Reactome:REACT_13738 "CYP4F2 omega-hydroxylates leukotriene B4, thus inactivating it, Homo sapiens"
xref: Reactome:REACT_13761 "CYP2C19 5-hydroxylates omeprazole, Homo sapiens"
xref: Reactome:REACT_13765 "CYP3A4 can N-demethylate loperaminde, Homo sapiens"
xref: Reactome:REACT_1437 "N-hydroxylation of 4-aminobiphenyl, Homo sapiens"
xref: Reactome:REACT_1447 "Ethylene is oxidized to Ethylene oxide by CYP1A1, Homo sapiens"
xref: Reactome:REACT_163 "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI), Homo sapiens"
xref: Reactome:REACT_1750 "Vinyl chloride is oxidized to 2-Chloroethylene oxide, Homo sapiens"
xref: Reactome:REACT_1995 "S-atom dealkylation of 6-methylmercaptopurine, Homo sapiens"
xref: Reactome:REACT_228 "Benzene is hydroxylated to phenol, Homo sapiens"
xref: Reactome:REACT_28287 "CYP4B1 can 12-hydroxylate arachidonic acid, Rattus norvegicus"
xref: Reactome:REACT_28569 "Cyclophosphamide is 4-hydroxylated by CYP2B6, Rattus norvegicus"
xref: Reactome:REACT_29648 "CYP4F2 omega-hydroxylates leukotriene B4, thus inactivating it, Danio rerio"
xref: Reactome:REACT_30083 "O-atom dealkylation of dextromethorphan, Taeniopygia guttata"
xref: Reactome:REACT_30413 "S-atom dealkylation of 6-methylmercaptopurine, Taeniopygia guttata"
xref: Reactome:REACT_305 "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide, Homo sapiens"
xref: Reactome:REACT_30596 "N-atom dealkylation of caffeine, Xenopus tropicalis"
xref: Reactome:REACT_30757 "CYP3A5 oxidises aflatoxin B1 to aflatoxin-8,9-oxide, Danio rerio"
xref: Reactome:REACT_31096 "CYP3A7 can 6beta-hydroxylate testosterone, Drosophila melanogaster"
xref: Reactome:REACT_31117 "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation, Sus scrofa"
xref: Reactome:REACT_31871 "Benzene is hydroxylated to phenol, Sus scrofa"
xref: Reactome:REACT_323 "O-atom dealkylation of dextromethorphan, Homo sapiens"
xref: Reactome:REACT_32309 "CYP4A11 omega-hydroxylates laurate, Danio rerio"
xref: Reactome:REACT_32769 "Dehalogenation of carbon tetrachloride to form a free radical, Sus scrofa"
xref: Reactome:REACT_32803 "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide, Mus musculus"
xref: Reactome:REACT_33304 "CYP4F3 omega-hydroxylates leukotriene B4, thus inactivating it, Bos taurus"
xref: Reactome:REACT_33556 "CYP2U1 can omega-hydroxylate arachidonate, Bos taurus"
xref: Reactome:REACT_33790 "Ethylene is oxidized to Ethylene oxide by CYP1A1, Rattus norvegicus"
xref: Reactome:REACT_33813 "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation, Rattus norvegicus"
xref: Reactome:REACT_33859 "Ethylene is oxidized to Ethylene oxide by CYP1A1, Sus scrofa"
xref: Reactome:REACT_33898 "Vinyl chloride is oxidized to 2-Chloroethylene oxide, Mus musculus"
xref: Reactome:REACT_33922 "CYP1B1 4-hydroxylates estradiol-17beta, Xenopus tropicalis"
xref: Reactome:REACT_34265 "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation, Danio rerio"
xref: Reactome:REACT_34271 "Benzene is hydroxylated to phenol, Mus musculus"
xref: Reactome:REACT_34597 "Dehalogenation of carbon tetrachloride to form a free radical, Canis familiaris"
xref: Reactome:REACT_44575 "O-atom dealkylation of dextromethorphan, Rattus norvegicus"
xref: Reactome:REACT_49029 "Ethylene is oxidized to Ethylene oxide by CYP1A1, Bos taurus"
xref: Reactome:REACT_499 "MEOS oxidizes ethanol to acetaldehyde, Homo sapiens"
xref: Reactome:REACT_54870 "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI), Bos taurus"
xref: Reactome:REACT_58290 "CYP1B1 4-hydroxylates estradiol-17beta, Mus musculus"
xref: Reactome:REACT_58734 "CYP4A11 omega-hydroxylates laurate, Bos taurus"
xref: Reactome:REACT_75504 "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide, Bos taurus"
xref: Reactome:REACT_77501 "CYP4F2 omega-hydroxylates leukotriene B4, thus inactivating it, Mus musculus"
xref: Reactome:REACT_77895 "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide, Taeniopygia guttata"
xref: Reactome:REACT_77958 "O-atom dealkylation of dextromethorphan, Sus scrofa"
xref: Reactome:REACT_78242 "Dehalogenation of carbon tetrachloride to form a free radical, Bos taurus"
xref: Reactome:REACT_78392 "N-hydroxylation of 4-aminobiphenyl, Canis familiaris"
xref: Reactome:REACT_78439 "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation, Mus musculus"
xref: Reactome:REACT_79087 "N-hydroxylation of 4-aminobiphenyl, Bos taurus"
xref: Reactome:REACT_79814 "Benzene is hydroxylated to phenol, Rattus norvegicus"
xref: Reactome:REACT_80448 "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation, Taeniopygia guttata"
xref: Reactome:REACT_80600 "Vinyl chloride is oxidized to 2-Chloroethylene oxide, Gallus gallus"
xref: Reactome:REACT_80785 "MEOS oxidizes ethanol to acetaldehyde, Canis familiaris"
xref: Reactome:REACT_81228 "CYP2U1 can omega-hydroxylate arachidonate, Mus musculus"
xref: Reactome:REACT_81599 "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide, Canis familiaris"
xref: Reactome:REACT_81769 "S-atom dealkylation of 6-methylmercaptopurine, Canis familiaris"
xref: Reactome:REACT_82090 "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation, Gallus gallus"
xref: Reactome:REACT_82546 "CYP4F8 hydroxylates prostaglandin H2, Xenopus tropicalis"
xref: Reactome:REACT_82713 "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation, Gallus gallus"
xref: Reactome:REACT_82917 "CYP4A11 omega-hydroxylates laurate, Sus scrofa"
xref: Reactome:REACT_83225 "CYP1B1 4-hydroxylates estradiol-17beta, Rattus norvegicus"
xref: Reactome:REACT_83236 "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation, Danio rerio"
xref: Reactome:REACT_83558 "N-atom dealkylation of caffeine, Canis familiaris"
xref: Reactome:REACT_83900 "Dehalogenation of carbon tetrachloride to form a free radical, Rattus norvegicus"
xref: Reactome:REACT_83932 "O-atom dealkylation of dextromethorphan, Xenopus tropicalis"
xref: Reactome:REACT_83946 "Vinyl chloride is oxidized to 2-Chloroethylene oxide, Bos taurus"
xref: Reactome:REACT_83985 "MEOS oxidizes ethanol to acetaldehyde, Rattus norvegicus"
xref: Reactome:REACT_84011 "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation, Bos taurus"
xref: Reactome:REACT_84240 "CYP4A11 omega-hydroxylates laurate, Mus musculus"
xref: Reactome:REACT_84540 "CYP3A5 oxidises aflatoxin B1 to aflatoxin-8,9-oxide, Gallus gallus"
xref: Reactome:REACT_84651 "Ethylene is oxidized to Ethylene oxide by CYP1A1, Mus musculus"
xref: Reactome:REACT_84804 "CYP4B1 can 12-hydroxylate arachidonic acid, Mus musculus"
xref: Reactome:REACT_85142 "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI), Mus musculus"
xref: Reactome:REACT_85617 "CYP2C19 5-hydroxylates omeprazole, Danio rerio"
xref: Reactome:REACT_85789 "CYP3A7 can 6beta-hydroxylate testosterone, Danio rerio"
xref: Reactome:REACT_86584 "CYP2F1 dehydrogenates 3-methylindole, Canis familiaris"
xref: Reactome:REACT_86609 "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide, Danio rerio"
xref: Reactome:REACT_87066 "CYP2U1 can omega-hydroxylate arachidonate, Xenopus tropicalis"
xref: Reactome:REACT_87553 "CYP1B1 4-hydroxylates estradiol-17beta, Taeniopygia guttata"
xref: Reactome:REACT_87557 "MEOS oxidizes ethanol to acetaldehyde, Taeniopygia guttata"
xref: Reactome:REACT_87585 "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation, Mus musculus"
xref: Reactome:REACT_88131 "CYP4B1 can 12-hydroxylate arachidonic acid, Bos taurus"
xref: Reactome:REACT_88365 "S-atom dealkylation of 6-methylmercaptopurine, Xenopus tropicalis"
xref: Reactome:REACT_88376 "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI), Rattus norvegicus"
xref: Reactome:REACT_88388 "CYP1B1 4-hydroxylates estradiol-17beta, Sus scrofa"
xref: Reactome:REACT_88780 "N-hydroxylation of 4-aminobiphenyl, Xenopus tropicalis"
xref: Reactome:REACT_89077 "Benzene is hydroxylated to phenol, Bos taurus"
xref: Reactome:REACT_89132 "Ethylene is oxidized to Ethylene oxide by CYP1A1, Xenopus tropicalis"
xref: Reactome:REACT_89288 "MEOS oxidizes ethanol to acetaldehyde, Sus scrofa"
xref: Reactome:REACT_89918 "CYP4A11 omega-hydroxylates laurate, Xenopus tropicalis"
xref: Reactome:REACT_90187 "Cyclophosphamide is 4-hydroxylated by CYP2B6, Bos taurus"
xref: Reactome:REACT_90287 "CYP4F2 omega-hydroxylates leukotriene B4, thus inactivating it, Xenopus tropicalis"
xref: Reactome:REACT_90452 "CYP2C19 5-hydroxylates omeprazole, Taeniopygia guttata"
xref: Reactome:REACT_90650 "N-atom dealkylation of caffeine, Rattus norvegicus"
xref: Reactome:REACT_90911 "CYP4F8 hydroxylates prostaglandin H2, Mus musculus"
xref: Reactome:REACT_91080 "CYP3A4 can N-demethylate loperaminde, Danio rerio"
xref: Reactome:REACT_91491 "CYP3A4 can N-demethylate loperaminde, Gallus gallus"
xref: Reactome:REACT_91742 "CYP4F3 omega-hydroxylates leukotriene B4, thus inactivating it, Rattus norvegicus"
xref: Reactome:REACT_91815 "O-atom dealkylation of dextromethorphan, Gallus gallus"
xref: Reactome:REACT_92052 "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI), Sus scrofa"
xref: Reactome:REACT_92115 "N-hydroxylation of 4-aminobiphenyl, Sus scrofa"
xref: Reactome:REACT_92163 "CYP4A11 omega-hydroxylates laurate, Gallus gallus"
xref: Reactome:REACT_92564 "O-atom dealkylation of dextromethorphan, Mus musculus"
xref: Reactome:REACT_92660 "CYP3A7 can 6beta-hydroxylate testosterone, Mus musculus"
xref: Reactome:REACT_92678 "CYP4F2 omega-hydroxylates leukotriene B4, thus inactivating it, Taeniopygia guttata"
xref: Reactome:REACT_92793 "CYP2U1 can omega-hydroxylate arachidonate, Sus scrofa"
xref: Reactome:REACT_92798 "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation, Bos taurus"
xref: Reactome:REACT_93025 "CYP3A5 oxidises aflatoxin B1 to aflatoxin-8,9-oxide, Drosophila melanogaster"
xref: Reactome:REACT_93071 "CYP2F1 dehydrogenates 3-methylindole, Rattus norvegicus"
xref: Reactome:REACT_93076 "Vinyl chloride is oxidized to 2-Chloroethylene oxide, Sus scrofa"
xref: Reactome:REACT_93786 "CYP3A4 can N-demethylate loperaminde, Mus musculus"
xref: Reactome:REACT_94252 "CYP2F1 dehydrogenates 3-methylindole, Mus musculus"
xref: Reactome:REACT_94389 "CYP1B1 4-hydroxylates estradiol-17beta, Gallus gallus"
xref: Reactome:REACT_95074 "CYP2U1 can omega-hydroxylate arachidonate, Danio rerio"
xref: Reactome:REACT_95175 "CYP4B1 can 12-hydroxylate arachidonic acid, Canis familiaris"
xref: Reactome:REACT_95629 "CYP2F1 dehydrogenates 3-methylindole, Xenopus tropicalis"
xref: Reactome:REACT_95768 "CYP4F8 hydroxylates prostaglandin H2, Taeniopygia guttata"
xref: Reactome:REACT_95891 "O-atom dealkylation of dextromethorphan, Canis familiaris"
xref: Reactome:REACT_96007 "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation, Danio rerio"
xref: Reactome:REACT_96630 "O-atom dealkylation of dextromethorphan, Bos taurus"
xref: Reactome:REACT_97001 "Vinyl chloride is oxidized to 2-Chloroethylene oxide, Canis familiaris"
xref: Reactome:REACT_97031 "S-atom dealkylation of 6-methylmercaptopurine, Mus musculus"
xref: Reactome:REACT_97724 "S-atom dealkylation of 6-methylmercaptopurine, Bos taurus"
xref: Reactome:REACT_97732 "Benzene is hydroxylated to phenol, Danio rerio"
xref: Reactome:REACT_97964 "CYP4F12 hydroxylates arachidonic acid, Xenopus tropicalis"
xref: Reactome:REACT_97980 "CYP4F12 hydroxylates arachidonic acid, Danio rerio"
xref: Reactome:REACT_98 "CYP4A11 omega-hydroxylates laurate, Homo sapiens"
xref: Reactome:REACT_98236 "CYP1B1 4-hydroxylates estradiol-17beta, Bos taurus"
xref: Reactome:REACT_98427 "CYP2C19 5-hydroxylates omeprazole, Bos taurus"
xref: Reactome:REACT_98774 "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation, Sus scrofa"
xref: Reactome:REACT_98874 "MEOS oxidizes ethanol to acetaldehyde, Mus musculus"
xref: Reactome:REACT_98906 "S-atom dealkylation of 6-methylmercaptopurine, Rattus norvegicus"
xref: Reactome:REACT_98989 "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation, Gallus gallus"
xref: Reactome:REACT_99056 "CYP3A7 can 6beta-hydroxylate testosterone, Gallus gallus"
xref: Reactome:REACT_99083 "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation, Rattus norvegicus"
xref: Reactome:REACT_99093 "Dehalogenation of carbon tetrachloride to form a free radical, Gallus gallus"
xref: Reactome:REACT_99244 "Vinyl chloride is oxidized to 2-Chloroethylene oxide, Taeniopygia guttata"
xref: Reactome:REACT_99362 "Dehalogenation of carbon tetrachloride to form a free radical, Taeniopygia guttata"
xref: Reactome:REACT_99726 "CYP4A11 omega-hydroxylates laurate, Canis familiaris"
is_a: GO:0005488 ! binding

[Term]
id: GO:0019826
name: oxygen sensor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with and responding, e.g. by conformational change, to changes in the cellular level of oxygen (O2)." [GOC:mah]
is_a: GO:0019825 ! oxygen binding

[Term]
id: GO:0019827
name: stem cell population maintenance
namespace: biological_process
def: "The process by which an organism or tissue maintains a population of stem cells of a single type.  This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types." [GOC:mah, ISBN:0878932437]
synonym: "maintenance of pluripotency" RELATED [GOC:vk]
is_a: GO:0044707 ! single-multicellular organism process
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0098727 ! maintenance of cell number

[Term]
id: GO:0019828
name: aspartic-type endopeptidase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of aspartic-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; the optimum reaction pH is below 5 due to an aspartic residue involved in the catalytic process." [GOC:ai]
synonym: "aspartic protease inhibitor activity" NARROW []
is_a: GO:0004866 ! endopeptidase inhibitor activity
relationship: negatively_regulates GO:0004190 ! aspartic-type endopeptidase activity

[Term]
id: GO:0019829
name: cation-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in)." [GOC:ai]
subset: gosubset_prok
synonym: "cation ABC transporter" NARROW []
synonym: "plasma membrane cation-transporting ATPase" NARROW []
is_a: GO:0008324 ! cation transmembrane transporter activity
is_a: GO:0042625 ! ATPase coupled ion transmembrane transporter activity

[Term]
id: GO:0019830
name: obsolete cadmium sensitivity/resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process.
synonym: "cadmium sensitivity/resistance" EXACT []
is_obsolete: true
replaced_by: GO:0046686

[Term]
id: GO:0019831
name: obsolete chromate sensitivity/resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process.
synonym: "chromate sensitivity/resistance" EXACT []
is_obsolete: true
replaced_by: GO:0046687

[Term]
id: GO:0019832
name: obsolete mercuric sensitivity/resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process.
synonym: "mercuric sensitivity/resistance" EXACT []
is_obsolete: true
replaced_by: GO:0046689

[Term]
id: GO:0019833
name: obsolete ice nucleation activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the formation of ice crystals in extracellular fluid at relatively high temperatures (up to -2 degrees C) to protect the organism from damage by intracellular ice formation. Ice nucleation proteins function by binding an ice crystal and then encouraging it to form larger crystals. Ice nucleation is a chemical process but these proteins can positively regulate it. There are two different uses of ice nucleation proteins: bacteria secrete them extracellularly to cause a host organism's cells to freeze and die, and fish use them to protect themselves from intracellular ice formation." [GOC:ai, GOC:jl]
comment: This term was made obsolete because it represents a biological process.
synonym: "ice nucleation activity" EXACT []
is_obsolete: true
consider: GO:0009405
consider: GO:0042309
consider: GO:0050825

[Term]
id: GO:0019834
name: phospholipase A2 inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of the enzyme phospholipase A2." [GOC:ai]
is_a: GO:0004859 ! phospholipase inhibitor activity
relationship: negatively_regulates GO:0004623 ! phospholipase A2 activity

[Term]
id: GO:0019835
name: cytolysis
namespace: biological_process
def: "The rupture of cell membranes and the loss of cytoplasm." [UniProtKB-KW:KW-0204]
subset: goslim_chembl
subset: gosubset_prok
synonym: "autolysin activity" RELATED []
synonym: "bacteriocin activity" RELATED []
synonym: "bacteriolytic toxin activity" RELATED []
synonym: "holin" RELATED []
synonym: "lysin activity" RELATED []
synonym: "lysis" BROAD []
synonym: "necrosis" RELATED []
xref: Wikipedia:Cytolysis
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0019836
name: hemolysis by symbiont of host erythrocytes
namespace: biological_process
def: "The cytolytic destruction of red blood cells, with the release of intracellular hemoglobin, in the host organism by a symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add, UniProtKB-KW:KW-0354]
subset: gosubset_prok
synonym: "haemolysis in host" EXACT []
synonym: "hemolysin activity" RELATED []
synonym: "hemolysis by symbiont of host RBCs" EXACT [CL:0000232]
synonym: "hemolysis by symbiont of host red blood cells" EXACT [CL:0000232]
synonym: "regulation of cytolysis of host cells by symbiont" EXACT [GOC:dph, GOC:tb]
is_a: GO:0001897 ! cytolysis by symbiont of host cells
is_a: GO:0052331 ! hemolysis in other organism involved in symbiotic interaction

[Term]
id: GO:0019837
name: obsolete herbicide susceptibility/resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process.
synonym: "herbicide susceptibility/resistance" EXACT []
is_obsolete: true
replaced_by: GO:0009635

[Term]
id: GO:0019838
name: growth factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate." [GOC:curators]
subset: goslim_chembl
synonym: "neurotrophin TRK receptor activity" RELATED []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0019840
name: isoprenoid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [GOC:jl]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0008289 ! lipid binding

[Term]
id: GO:0019841
name: retinol binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with retinol, vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A. Retinol is an intermediate in the vision cycle and it also plays a role in growth and differentiation." [CHEBI:50211, GOC:curators]
synonym: "vitamin A1 alcohol binding" EXACT []
synonym: "vitamin A1 binding" EXACT []
is_a: GO:0005501 ! retinoid binding
is_a: GO:0019842 ! vitamin binding
is_a: GO:0043178 ! alcohol binding

[Term]
id: GO:0019842
name: vitamin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0036094 ! small molecule binding

[Term]
id: GO:0019843
name: rRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with ribosomal RNA." [GOC:jl]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_yeast
subset: gosubset_prok
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0019844
name: obsolete endotoxin activity
namespace: molecular_function
def: "OBSOLETE. The function of any microbial toxin that cannot be easily separated from the structure of the cell." [ISBN:0198506732]
comment: This term was made obsolete because it represents a class of gene products.
synonym: "endotoxin activity" EXACT []
is_obsolete: true
consider: GO:0005622
consider: GO:0009405
consider: GO:0050827

[Term]
id: GO:0019845
name: obsolete exotoxin activity
namespace: molecular_function
def: "OBSOLETE. The function of a toxin formed by a microorganism and secreted into the surrounding medium." [ISBN:0198506732]
comment: This term was made obsolete because it represents a class of gene products.
synonym: "exotoxin activity" EXACT []
is_obsolete: true
consider: GO:0005576
consider: GO:0009405
consider: GO:0050827

[Term]
id: GO:0019846
name: obsolete enterotoxin activity
namespace: molecular_function
def: "OBSOLETE. Acts as to cause injury to the intestinal mucosa of other living organisms." [ISBN:0198506732]
comment: This term was made obsolete because it represents a class of gene products.
synonym: "enterotoxin activity" EXACT []
is_obsolete: true
consider: GO:0009405
consider: GO:0050827

[Term]
id: GO:0019847
name: obsolete neurotoxin activity
namespace: molecular_function
def: "OBSOLETE. Acts to inhibit neural function in another living organism." [GOC:jl]
comment: This term was made obsolete because it represents a class of gene products.
synonym: "neurotoxin activity" EXACT []
is_obsolete: true
consider: GO:0009405
consider: GO:0050827

[Term]
id: GO:0019848
name: obsolete conotoxin activity
namespace: molecular_function
def: "OBSOLETE. Acts to inhibit neural function in another organism by inhibiting voltage-gated calcium ion channels and neurotransmitter release. This function is thought to be specific to the venom of two marine snail species." [GOC:jl, ISBN:0198506732]
comment: This term was made obsolete because it represents a gene product.
synonym: "conotoxin activity" EXACT []
is_obsolete: true
consider: GO:0019855
consider: GO:0046929

[Term]
id: GO:0019849
name: obsolete cytotoxin activity
namespace: molecular_function
def: "OBSOLETE. Acts as to cause injury to other living cells." [GOC:jl]
comment: This term was made obsolete because it represents a class of gene products.
synonym: "cytotoxin activity" EXACT []
is_obsolete: true
consider: GO:0009405
consider: GO:0050827

[Term]
id: GO:0019852
name: L-ascorbic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [CHEBI:38290, GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "ascorbate metabolic process" EXACT []
synonym: "ascorbate metabolism" EXACT []
synonym: "L-ascorbic acid metabolism" EXACT []
synonym: "vitamin C metabolic process" EXACT []
synonym: "vitamin C metabolism" EXACT []
xref: Reactome:REACT_104538 "Vitamin C (ascorbate) metabolism, Taeniopygia guttata"
xref: Reactome:REACT_105324 "Vitamin C (ascorbate) metabolism, Gallus gallus"
xref: Reactome:REACT_107753 "Vitamin C (ascorbate) metabolism, Rattus norvegicus"
xref: Reactome:REACT_107989 "Vitamin C (ascorbate) metabolism, Danio rerio"
xref: Reactome:REACT_108418 "Vitamin C (ascorbate) metabolism, Drosophila melanogaster"
xref: Reactome:REACT_108458 "Vitamin C (ascorbate) metabolism, Oryza sativa"
xref: Reactome:REACT_11202 "Vitamin C (ascorbate) metabolism, Homo sapiens"
xref: Reactome:REACT_112496 "Vitamin C (ascorbate) metabolism, Plasmodium falciparum"
xref: Reactome:REACT_113522 "Vitamin C (ascorbate) metabolism, Mycobacterium tuberculosis"
xref: Reactome:REACT_115090 "Vitamin C (ascorbate) metabolism, Dictyostelium discoideum"
xref: Reactome:REACT_34747 "Vitamin C (ascorbate) metabolism, Bos taurus"
xref: Reactome:REACT_79643 "Vitamin C (ascorbate) metabolism, Sus scrofa"
xref: Reactome:REACT_81219 "Vitamin C (ascorbate) metabolism, Caenorhabditis elegans"
xref: Reactome:REACT_81365 "Vitamin C (ascorbate) metabolism, Arabidopsis thaliana"
xref: Reactome:REACT_81649 "Vitamin C (ascorbate) metabolism, Mus musculus"
xref: Reactome:REACT_97289 "Vitamin C (ascorbate) metabolism, Canis familiaris"
xref: Reactome:REACT_99550 "Vitamin C (ascorbate) metabolism, Xenopus tropicalis"
is_a: GO:0005996 ! monosaccharide metabolic process
is_a: GO:0006767 ! water-soluble vitamin metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0019853
name: L-ascorbic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions." [CHEBI:38290, GOC:ma, ISBN:0198547684]
subset: gosubset_prok
synonym: "ascorbate biosynthesis" EXACT []
synonym: "ascorbate biosynthetic process" EXACT []
synonym: "L-ascorbic acid anabolism" EXACT []
synonym: "L-ascorbic acid biosynthesis" EXACT []
synonym: "L-ascorbic acid formation" EXACT []
synonym: "L-ascorbic acid synthesis" EXACT []
synonym: "vitamin C biosynthesis" EXACT []
synonym: "vitamin C biosynthetic process" EXACT []
xref: MetaCyc:PWY-882
is_a: GO:0019852 ! L-ascorbic acid metabolic process
is_a: GO:0042364 ! water-soluble vitamin biosynthetic process
is_a: GO:0046364 ! monosaccharide biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process

[Term]
id: GO:0019854
name: L-ascorbic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions." [CHEBI:38290, GOC:go_curators]
subset: gosubset_prok
synonym: "ascorbate catabolic process" EXACT []
synonym: "ascorbate catabolism" EXACT []
synonym: "L-ascorbic acid breakdown" EXACT []
synonym: "L-ascorbic acid catabolism" EXACT []
synonym: "L-ascorbic acid degradation" EXACT []
synonym: "vitamin C catabolic process" EXACT []
synonym: "vitamin C catabolism" EXACT []
xref: MetaCyc:PWY0-301
is_a: GO:0019852 ! L-ascorbic acid metabolic process
is_a: GO:0042365 ! water-soluble vitamin catabolic process
is_a: GO:0046365 ! monosaccharide catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process

[Term]
id: GO:0019855
name: calcium channel inhibitor activity
namespace: molecular_function
def: "Stops, prevents, or reduces the activity of a calcium channel." [GOC:mah]
is_a: GO:0005246 ! calcium channel regulator activity
is_a: GO:0008200 ! ion channel inhibitor activity
relationship: negatively_regulates GO:0005262 ! calcium channel activity

[Term]
id: GO:0019856
name: pyrimidine nucleobase biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases." [CHEBI:26432, GOC:go_curators]
subset: gosubset_prok
synonym: "pyrimidine base anabolism" EXACT []
synonym: "pyrimidine base biosynthesis" EXACT []
synonym: "pyrimidine base biosynthetic process" EXACT [GOC:go_curators]
synonym: "pyrimidine base formation" EXACT []
synonym: "pyrimidine base synthesis" EXACT []
is_a: GO:0006206 ! pyrimidine nucleobase metabolic process
is_a: GO:0046112 ! nucleobase biosynthetic process
is_a: GO:0072528 ! pyrimidine-containing compound biosynthetic process

[Term]
id: GO:0019857
name: 5-methylcytosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 5-methylcytosine, a methylated base of DNA." [GOC:ai]
subset: gosubset_prok
synonym: "5-methylcytosine metabolism" EXACT []
is_a: GO:0072527 ! pyrimidine-containing compound metabolic process

[Term]
id: GO:0019858
name: cytosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cytosine, 4-amino-2-hydroxypyrimidine, a pyrimidine derivative that is one of the five main bases found in nucleic acids; it occurs widely in cytidine derivatives." [GOC:ai]
subset: gosubset_prok
synonym: "cytosine metabolism" EXACT []
is_a: GO:0006206 ! pyrimidine nucleobase metabolic process

[Term]
id: GO:0019859
name: thymine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base." [GOC:go_curators]
subset: gosubset_prok
synonym: "thymine metabolism" EXACT []
is_a: GO:0006206 ! pyrimidine nucleobase metabolic process

[Term]
id: GO:0019860
name: uracil metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA." [GOC:go_curators]
subset: gosubset_prok
synonym: "uracil metabolism" EXACT []
is_a: GO:0006206 ! pyrimidine nucleobase metabolic process

[Term]
id: GO:0019861
name: obsolete flagellum
namespace: cellular_component
alt_id: GO:0008223
def: "OBSOLETE. Long whiplike or feathery structures borne either singly or in groups by the motile cells of many bacteria and unicellular eukaryotes and by the motile male gametes of many eukaryotic organisms, which propel the cell through a liquid medium." [UniProtKB-KW:KW-0282]
comment: This term was made obsolete because it was an unnecessary grouping term. Eukaryotic flagella were deemed to be equivalent to cilia and merged, so the only remaining child to this term was 'bacterial-type flagellum ; GO:0009288'.
subset: goslim_metagenomics
subset: goslim_pir
subset: gosubset_prok
synonym: "flagellum" EXACT []
xref: Wikipedia:Flagellum
is_obsolete: true
consider: GO:0005929
consider: GO:0009288

[Term]
id: GO:0019862
name: IgA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an immunoglobulin of an IgA isotype." [GOC:add, ISBN:0781735149]
is_a: GO:0019865 ! immunoglobulin binding

[Term]
id: GO:0019863
name: IgE binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an immunoglobulin of the IgE isotype." [GOC:add, ISBN:0781735149]
is_a: GO:0019865 ! immunoglobulin binding

[Term]
id: GO:0019864
name: IgG binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an immunoglobulin of an IgG isotype." [GOC:add, ISBN:0781735149]
subset: goslim_chembl
is_a: GO:0019865 ! immunoglobulin binding

[Term]
id: GO:0019865
name: immunoglobulin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an immunoglobulin." [GOC:ma]
is_a: GO:0032403 ! protein complex binding

[Term]
id: GO:0019866
name: organelle inner membrane
namespace: cellular_component
def: "The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites." [GOC:mah]
comment: See also the cellular component term 'outer membrane ; GO:0019867'.
subset: gosubset_prok
is_a: GO:0031090 ! organelle membrane
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0031967 ! organelle envelope

[Term]
id: GO:0019867
name: outer membrane
namespace: cellular_component
def: "The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites." [GOC:go_curators]
subset: goslim_metagenomics
subset: gosubset_prok
is_a: GO:0016020 ! membrane

[Term]
id: GO:0019869
name: chloride channel inhibitor activity
namespace: molecular_function
def: "Stops, prevents, or reduces the activity of a chloride channel." [GOC:mah]
is_a: GO:0008200 ! ion channel inhibitor activity
is_a: GO:0017081 ! chloride channel regulator activity
relationship: negatively_regulates GO:0005254 ! chloride channel activity

[Term]
id: GO:0019870
name: potassium channel inhibitor activity
namespace: molecular_function
def: "Stops, prevents, or reduces the activity of a potassium channel." [GOC:mah]
is_a: GO:0008200 ! ion channel inhibitor activity
is_a: GO:0015459 ! potassium channel regulator activity
relationship: negatively_regulates GO:0005267 ! potassium channel activity

[Term]
id: GO:0019871
name: sodium channel inhibitor activity
namespace: molecular_function
alt_id: GO:0019868
def: "Stops, prevents, or reduces the activity of a sodium channel." [GOC:mah]
is_a: GO:0008200 ! ion channel inhibitor activity
is_a: GO:0017080 ! sodium channel regulator activity
relationship: negatively_regulates GO:0005272 ! sodium channel activity

[Term]
id: GO:0019872
name: streptomycin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of streptomycin, a commonly used antibiotic in cell culture media; it acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome." [CHEBI:17076, GOC:curators]
subset: gosubset_prok
synonym: "streptomycin anabolism" EXACT []
synonym: "streptomycin biosynthesis" EXACT []
synonym: "streptomycin formation" EXACT []
synonym: "streptomycin synthesis" EXACT []
is_a: GO:0030648 ! aminoglycoside antibiotic biosynthetic process
is_a: GO:0046173 ! polyol biosynthetic process
is_a: GO:0046343 ! streptomycin metabolic process

[Term]
id: GO:0019873
name: obsolete tellurium sensitivity/resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process.
synonym: "tellurium sensitivity/resistance" EXACT []
is_obsolete: true
replaced_by: GO:0046690

[Term]
id: GO:0019874
name: 6-aminohexanoate-cyclic-dimer hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,8-diazacyclotetradecane-2,9-dione + H(2)O = N-(6-aminohexanoyl)-6-aminohexanoate." [EC:3.5.2.12, RHEA:16228]
subset: gosubset_prok
synonym: "1,8-diazacyclotetradecane-2,9-dione lactamhydrolase activity" EXACT [EC:3.5.2.12]
xref: EC:3.5.2.12
xref: KEGG:R03448
xref: MetaCyc:3.5.2.12-RXN
xref: RHEA:16228
xref: UM-BBD_reactionID:r1097
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0019875
name: 6-aminohexanoate-dimer hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-(6-aminohexanoyl)-6-aminohexanoate + H2O = 2 6-aminohexanoate." [EC:3.5.1.46]
subset: gosubset_prok
synonym: "6-aminohexanoic acid oligomer hydrolase activity" EXACT [EC:3.5.1.46]
synonym: "N-(6-aminohexanoyl)-6-aminohexanoate amidohydrolase activity" EXACT [EC:3.5.1.46]
xref: EC:3.5.1.46
xref: MetaCyc:RXN-3962
xref: RHEA:21367
xref: UM-BBD_enzymeID:e0673
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0019876
name: nylon catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of nylon, a polymer where the main polymer chain comprises recurring amide groups; these compounds are generally formed from combinations of diamines, diacids and amino acids." [UniProtKB-KW:KW-0549]
subset: gosubset_prok
synonym: "nylon breakdown" EXACT []
synonym: "nylon catabolism" EXACT []
synonym: "nylon degradation" EXACT []
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0042198 ! nylon metabolic process

[Term]
id: GO:0019877
name: diaminopimelate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of diaminopimelate, both as an intermediate in lysine biosynthesis and as a component (as meso-diaminopimelate) of the peptidoglycan of Gram-negative bacterial cell walls." [GOC:ma, ISBN:0198547684]
subset: gosubset_prok
synonym: "diaminopimelate anabolism" EXACT []
synonym: "diaminopimelate biosynthesis" EXACT []
synonym: "diaminopimelate formation" EXACT []
synonym: "diaminopimelate synthesis" EXACT []
is_a: GO:0008652 ! cellular amino acid biosynthetic process
is_a: GO:0043650 ! dicarboxylic acid biosynthetic process
is_a: GO:0046451 ! diaminopimelate metabolic process

[Term]
id: GO:0019878
name: lysine biosynthetic process via aminoadipic acid
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lysine by the aminoadipic pathway." [GOC:go_curators]
subset: gosubset_prok
synonym: "lysine anabolism via aminoadipic acid" EXACT []
synonym: "lysine biosynthesis, aminoadipic acid pathway" EXACT []
synonym: "lysine biosynthesis, aminoadipic pathway" EXACT []
synonym: "lysine biosynthetic process, aminoadipic acid pathway" EXACT []
synonym: "lysine biosynthetic process, aminoadipic pathway" EXACT []
synonym: "lysine formation via aminoadipic acid" EXACT []
synonym: "lysine synthesis via aminoadipic acid" EXACT []
is_a: GO:0009085 ! lysine biosynthetic process

[Term]
id: GO:0019879
name: peptidyl-thyronine biosynthetic process from peptidyl-tyrosine
namespace: biological_process
def: "The formation of peptidyl-thyronine from peptidyl-tyrosine in thyroglobulin by phenyl transfer coupled with the formation of peptidyl-dehydroalanine." [GOC:jsg]
comment: See also the biological process term 'peptidyl-dehydroalanine biosynthetic process from peptidyl-tyrosine or peptidyl-serine ; GO:0018250'.
subset: gosubset_prok
synonym: "peptidyl-thyronine anabolism from peptidyl-tyrosine" EXACT []
synonym: "peptidyl-thyronine formation from peptidyl-tyrosine" EXACT []
synonym: "peptidyl-thyronine synthesis from peptidyl-tyrosine" EXACT []
is_a: GO:0018212 ! peptidyl-tyrosine modification
is_a: GO:0044249 ! cellular biosynthetic process
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0019880
name: obsolete bacteriocin susceptibility/resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process.
synonym: "bacteriocin susceptibility/resistance" EXACT []
is_obsolete: true
replaced_by: GO:0046678

[Term]
id: GO:0019881
name: obsolete streptomycin susceptibility/resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process.
synonym: "streptomycin susceptibility/resistance" EXACT []
is_obsolete: true
replaced_by: GO:0046679

[Term]
id: GO:0019882
name: antigen processing and presentation
namespace: biological_process
alt_id: GO:0030333
def: "The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149, PMID:15771591, PMID:15928678]
comment: This term was improved by GO_REF:0000022. It was renamed and redefined.
synonym: "antigen presentation" EXACT []
synonym: "antigen processing" EXACT []
xref: Wikipedia:Antigen_presentation
is_a: GO:0002376 ! immune system process

[Term]
id: GO:0019883
name: antigen processing and presentation of endogenous antigen
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses antigen (peptide or lipid) of endogenous origin on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591, PMID:15928678]
synonym: "antigen presentation, endogenous antigen" EXACT []
is_a: GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0019884
name: antigen processing and presentation of exogenous antigen
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses antigen (peptide or lipid) of exogenous origin on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591, PMID:15928678]
synonym: "antigen presentation, exogenous antigen" EXACT []
is_a: GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0019885
name: antigen processing and presentation of endogenous peptide antigen via MHC class I
namespace: biological_process
alt_id: GO:0048004
def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:15771591]
synonym: "antigen presentation, endogenous peptide antigen" BROAD []
synonym: "antigen processing, endogenous antigen via major histocompatibility complex class I" BROAD []
synonym: "antigen processing, endogenous antigen via MHC class I" BROAD []
synonym: "endogenous peptide antigen processing and presentation via MHC class I" EXACT []
is_a: GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I
is_a: GO:0002483 ! antigen processing and presentation of endogenous peptide antigen

[Term]
id: GO:0019886
name: antigen processing and presentation of exogenous peptide antigen via MHC class II
namespace: biological_process
alt_id: GO:0042591
alt_id: GO:0048005
def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein." [GOC:add, ISBN:0781735149, PMID:15771591]
synonym: "antigen presentation, exogenous antigen via MHC class II" BROAD []
synonym: "antigen presentation, exogenous peptide antigen" BROAD []
synonym: "antigen processing, exogenous antigen via major histocompatibility complex class II" BROAD []
synonym: "exogenous peptide antigen processing and presentation via MHC class II" EXACT []
is_a: GO:0002478 ! antigen processing and presentation of exogenous peptide antigen
is_a: GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II

[Term]
id: GO:0019887
name: protein kinase regulator activity
namespace: molecular_function
def: "Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai]
subset: gosubset_prok
is_a: GO:0019207 ! kinase regulator activity
relationship: has_part GO:0019901 ! protein kinase binding
relationship: part_of GO:0045859 ! regulation of protein kinase activity
relationship: regulates GO:0004672 ! protein kinase activity

[Term]
id: GO:0019888
name: protein phosphatase regulator activity
namespace: molecular_function
def: "Modulates the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule." [GOC:ai]
is_a: GO:0019208 ! phosphatase regulator activity
relationship: has_part GO:0019903 ! protein phosphatase binding
relationship: regulates GO:0004721 ! phosphoprotein phosphatase activity

[Term]
id: GO:0019889
name: pteridine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "pteridine metabolism" EXACT []
is_a: GO:0042558 ! pteridine-containing compound metabolic process

[Term]
id: GO:0019893
name: obsolete DNA replication inhibitor
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it does not represent a true molecular function.
synonym: "DNA replication inhibitor" EXACT []
is_obsolete: true
replaced_by: GO:0008156

[Term]
id: GO:0019894
name: kinesin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation." [GOC:curators, PMID:8606779]
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0019895
name: kinesin-associated mitochondrial adaptor activity
namespace: molecular_function
def: "The activity of linking kinesins, cytoplasmic proteins responsible for moving vesicles and organelles towards the distal end of microtubules, to mitochondria." [PMID:12495622]
is_a: GO:0019894 ! kinesin binding
is_a: GO:0030674 ! protein binding, bridging

[Term]
id: GO:0019896
name: axon transport of mitochondrion
namespace: biological_process
def: "The directed movement of mitochondria along microtubules in nerve cell axons." [GOC:ai]
synonym: "axon transport of mitochondria" EXACT []
is_a: GO:0008088 ! axo-dendritic transport
is_a: GO:0047497 ! mitochondrion transport along microtubule
relationship: occurs_in GO:1904115 ! axon cytoplasm

[Term]
id: GO:0019897
name: extrinsic component of plasma membrane
namespace: cellular_component
alt_id: GO:0000157
def: "The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:curators, GOC:dos]
subset: gosubset_prok
synonym: "extrinsic to plasma membrane" EXACT []
synonym: "juxtamembrane" BROAD []
synonym: "peripheral plasma membrane protein" EXACT []
is_a: GO:0019898 ! extrinsic component of membrane
is_a: GO:0044459 ! plasma membrane part
intersection_of: GO:0019898 ! extrinsic component of membrane
intersection_of: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0005886 ! plasma membrane

[Term]
id: GO:0019898
name: extrinsic component of membrane
namespace: cellular_component
alt_id: GO:0030396
def: "The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah]
comment: Note that proteins extrinsic to membranes can be removed by treatments that do not disrupt the membrane, such as salt solutions.
subset: gosubset_prok
synonym: "extrinsic to membrane" EXACT []
synonym: "peripheral membrane protein" EXACT []
xref: Wikipedia:Peripheral_membrane_protein
is_a: GO:0044425 ! membrane part

[Term]
id: GO:0019899
name: enzyme binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any enzyme." [GOC:jl]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_yeast
subset: gosubset_prok
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0019900
name: kinase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl]
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0019901
name: protein kinase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]
is_a: GO:0019900 ! kinase binding

[Term]
id: GO:0019902
name: phosphatase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any phosphatase." [GOC:jl]
subset: gosubset_prok
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0019903
name: protein phosphatase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any protein phosphatase." [GOC:jl]
subset: gosubset_prok
is_a: GO:0019902 ! phosphatase binding

[Term]
id: GO:0019904
name: protein domain specific binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific domain of a protein." [GOC:go_curators]
subset: goslim_chembl
subset: gosubset_prok
synonym: "protein domain-specific binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0019905
name: syntaxin binding
namespace: molecular_function
alt_id: GO:0030347
alt_id: GO:0030349
alt_id: GO:0050430
alt_id: GO:0051535
def: "Interacting selectively and non-covalently with a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse." [ISBN:0198506732]
synonym: "syntaxin-13 binding" NARROW []
synonym: "syntaxin-2 binding" NARROW []
synonym: "syntaxin-5 binding" NARROW []
synonym: "syntaxin-6 binding" NARROW []
is_a: GO:0000149 ! SNARE binding

[Term]
id: GO:0019907
name: cyclin-dependent protein kinase activating kinase holoenzyme complex
namespace: cellular_component
def: "A cyclin-dependent kinase activating kinase complex capable of activating cyclin-dependent kinases by threonine phosphorylation, thus regulating cell cycle progression. consists of a kinase, cyclin and optional assembly factors, in human CDK7, CCNH and MNAT1. CAK activity is itself regulated throughout the cell cycle by T-loop phosphorylation of its kinase component (CDK7 in human). Phosphorylation of serine residues during mitosis inactivates the enzyme. Also capable of CAK phosphorylating the carboxyl-terminal domain (CTD) of RNA polymerase II and other transcription activating proteins, as part of the general transcription factor TFIIH." [GOC:bhm, PMID:8752210]
synonym: "CAK complex" EXACT []
synonym: "CDK-activating kinase complex" EXACT []
xref: IntAct:EBI-1246076
xref: IntAct:EBI-9868598
is_a: GO:0019908 ! nuclear cyclin-dependent protein kinase holoenzyme complex
is_a: GO:0032806 ! carboxy-terminal domain protein kinase complex

[Term]
id: GO:0019908
name: nuclear cyclin-dependent protein kinase holoenzyme complex
namespace: cellular_component
def: "Cyclin-dependent protein kinase (CDK) complex found in the nucleus." [GOC:krc]
synonym: "CDK holoenzyme" BROAD []
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex
is_a: GO:0044428 ! nuclear part
intersection_of: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex
intersection_of: part_of GO:0005634 ! nucleus
relationship: part_of GO:0005634 ! nucleus

[Term]
id: GO:0019909
name: [pyruvate dehydrogenase (lipoamide)] phosphatase regulator activity
namespace: molecular_function
def: "Modification of the activity of the enzyme [pyruvate dehydrogenase (lipoamide)] phosphatase." [EC:3.1.3.43, GOC:ai]
synonym: "[pyruvate dehydrogenase (lipoamide)] phosphatase, intrinsic regulator activity" NARROW []
is_a: GO:0019888 ! protein phosphatase regulator activity
relationship: regulates GO:0004741 ! [pyruvate dehydrogenase (lipoamide)] phosphatase activity

[Term]
id: GO:0019910
name: mitochondrial pyruvate dehydrogenase (lipoamide) phosphatase complex
namespace: cellular_component
def: "A mitochondrial complex of a regulatory and catalytic subunit that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex. An example of this component is found in Mus musculus." [GOC:mtg_sensu, PMID:9395502]
comment: See also the cellular component term 'mitochondrial pyruvate dehydrogenase complex ; GO:0005967'.
is_a: GO:0045253 ! pyruvate dehydrogenase (lipoamide) phosphatase complex
is_a: GO:0098798 ! mitochondrial protein complex
intersection_of: GO:0045253 ! pyruvate dehydrogenase (lipoamide) phosphatase complex
intersection_of: part_of GO:0005739 ! mitochondrion
relationship: part_of GO:0005739 ! mitochondrion
relationship: part_of GO:0005759 ! mitochondrial matrix

[Term]
id: GO:0019911
name: structural constituent of myelin sheath
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of the myelin sheath of a nerve." [GOC:mah]
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0019912
name: cyclin-dependent protein kinase activating kinase activity
namespace: molecular_function
alt_id: GO:0019913
def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; increases the activity of a cyclin-dependent protein kinase (CDK)." [GOC:go_curators]
synonym: "CAK" EXACT []
synonym: "cdk-activating kinase activity" EXACT []
synonym: "cyclin-dependent protein kinase activating kinase, intrinsic catalyst activity" EXACT []
xref: EC:2.7.11.-
is_a: GO:0004672 ! protein kinase activity
is_a: GO:0030295 ! protein kinase activator activity
relationship: part_of GO:1904031 ! positive regulation of cyclin-dependent protein kinase activity

[Term]
id: GO:0019914
name: cyclin-dependent protein kinase activating kinase regulator activity
namespace: molecular_function
def: "Modulation of the activity of the enzyme cyclin-dependent protein kinase activating kinase." [GOC:ai]
synonym: "cyclin-dependent protein kinase activating kinase, intrinsic regulator activity" NARROW []
xref: EC:2.7.1.-
is_a: GO:0019887 ! protein kinase regulator activity
relationship: regulates GO:0019912 ! cyclin-dependent protein kinase activating kinase activity

[Term]
id: GO:0019915
name: lipid storage
namespace: biological_process
def: "The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:dph, GOC:mah, GOC:tb, PMID:11102830]
synonym: "lipid retention" EXACT [GOC:dph, GOC:tb]
synonym: "lipid sequestering" NARROW [GOC:dph, GOC:tb]
synonym: "lipid sequestration" NARROW [GOC:dph, GOC:tb]
synonym: "retention of lipids" EXACT [GOC:dph, GOC:tb]
synonym: "sequestering of lipids" NARROW [GOC:dph, GOC:tb]
synonym: "sequestration of lipid" NARROW [GOC:dph, GOC:tb]
synonym: "sequestration of lipids" EXACT [GOC:dph, GOC:tb]
synonym: "storage of lipids" EXACT []
is_a: GO:0051235 ! maintenance of location
relationship: part_of GO:0010876 ! lipid localization

[Term]
id: GO:0019916
name: peptidyl-D-alanine racemization, direct
namespace: biological_process
def: "The racemization of peptidyl-alanine." [RESID:AA0191]
subset: gosubset_prok
xref: RESID:AA0191
is_a: GO:0019122 ! peptidyl-D-alanine racemization

[Term]
id: GO:0019917
name: peptidyl-D-alanine racemization via peptidyl-L-serine
namespace: biological_process
def: "The dehydration of peptidyl-serine, followed by hydrogenation to produce peptidyl-D-alanine." [RESID:AA0191]
subset: gosubset_prok
xref: RESID:AA0191
is_a: GO:0019122 ! peptidyl-D-alanine racemization

[Term]
id: GO:0019918
name: peptidyl-arginine methylation, to symmetrical-dimethyl arginine
namespace: biological_process
def: "The process of methylation of peptidyl-arginine to form peptidyl-N(omega),N'(omega)-dimethyl-L-arginine." [RESID:AA0067, RESID:AA0069]
subset: gosubset_prok
xref: RESID:AA0067
xref: RESID:AA0069
is_a: GO:0035247 ! peptidyl-arginine omega-N-methylation

[Term]
id: GO:0019919
name: peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
namespace: biological_process
def: "The process of methylation of peptidyl-arginine to form peptidyl-N(omega),N(omega)-dimethyl-L-arginine." [RESID:AA0068, RESID:AA0069]
subset: gosubset_prok
synonym: "peptidyl-arginine methylation, to unsymmetrical-dimethyl arginine" EXACT []
xref: RESID:AA0068
xref: RESID:AA0069
is_a: GO:0035247 ! peptidyl-arginine omega-N-methylation

[Term]
id: GO:0019920
name: peptidyl-1-thioglycine biosynthetic process, internal
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of internal peptidyl-1-thioglycine, which has an internal C=S bond, instead of an internal C=O bond, in the peptide." [GOC:go_curators, http://www.uni-marburg.de/mpi/thauer/thauer_res.html, RESID:AA0265]
subset: gosubset_prok
synonym: "peptidyl-1-thioglycine anabolism, internal" EXACT []
synonym: "peptidyl-1-thioglycine formation, internal" EXACT []
synonym: "peptidyl-1-thioglycine synthesis, internal" EXACT []
xref: RESID:AA0265
is_a: GO:0018173 ! peptidyl-1-thioglycine biosynthetic process from peptidyl-glycine

[Term]
id: GO:0019921
name: peptidyl-1-thioglycine biosynthetic process, carboxy-terminal
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of carboxy-terminal peptidyl-1-thioglycine, which has a carboxy-terminal thiocarboxy-C(=O)-SH bond." [GOC:go_curators, http://www.uni-marburg.de/mpi/thauer/thauer_res.html, RESID:AA0265]
subset: gosubset_prok
synonym: "peptidyl-1-thioglycine anabolism, carboxy-terminal" EXACT []
synonym: "peptidyl-1-thioglycine formation, carboxy-terminal" EXACT []
synonym: "peptidyl-1-thioglycine synthesis, carboxy-terminal" EXACT []
xref: RESID:AA0265
is_a: GO:0018173 ! peptidyl-1-thioglycine biosynthetic process from peptidyl-glycine

[Term]
id: GO:0019922
name: protein-chromophore linkage via peptidyl-cysteine
namespace: biological_process
def: "The covalent linking of a chromophore to a protein via peptidyl-cysteines." [GOC:ma]
subset: gosubset_prok
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018298 ! protein-chromophore linkage

[Term]
id: GO:0019923
name: alpha-1-microglobulin-chromophore linkage
namespace: biological_process
def: "The covalent linking of the alpha-1-microglobulin chromophore to the protein; the structure of the chromophore is not known. It is probably heterogeneous and involving two cysteines in thioether bonds." [RESID:AA0224]
subset: gosubset_prok
xref: RESID:AA0224
is_a: GO:0019922 ! protein-chromophore linkage via peptidyl-cysteine

[Term]
id: GO:0019926
name: peptidyl-tryptophan oxidation to tryptophyl quinone
namespace: biological_process
def: "The oxidation of peptidyl-tryptophan to form tryptophan-6,7-dione, otherwise known as tryptophyl quinone, which is further modified by cross-linking to either tryptophan or cysteine." [PMID:2028257, RESID:AA0148]
comment: See also the biological process term 'peptide cross-linking via 4'-(L-tryptophan)-L-tryptophyl quinone ; GO:0018069'.
subset: gosubset_prok
is_a: GO:0018158 ! protein oxidation
is_a: GO:0018211 ! peptidyl-tryptophan modification
relationship: part_of GO:0018069 ! peptide cross-linking via 4'-(L-tryptophan)-L-tryptophyl quinone

[Term]
id: GO:0019927
name: peptide cross-linking via 4'-(S-L-cysteinyl)-L-tryptophyl quinone
namespace: biological_process
def: "The cross-linking of a cysteine residue to tryptophyl quinone to form 4'-(S-L-cysteinyl)-L-tryptophyl quinone, a cofactor found at the active site of amine dehydrogenase." [PDB:1JJU, PMID:11555656, PMID:11717396, RESID:AA0313]
subset: gosubset_prok
xref: RESID:AA0313
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0019928
name: peptide cross-linking via 3-(S-L-cysteinyl)-L-aspartic acid
namespace: biological_process
def: "The cross-linking of a cysteine residue to an aspartic acid residue to form 3-(S-L-cysteinyl)-L-aspartic acid." [PDB:1JJU, PMID:11555656, PMID:11717396, RESID:AA0314]
subset: gosubset_prok
xref: RESID:AA0314
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018197 ! peptidyl-aspartic acid modification
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0019929
name: peptide cross-linking via 4-(S-L-cysteinyl)-L-glutamic acid
namespace: biological_process
def: "The cross-linking of a cysteine residue to a glutamic acid residue to form 4-(S-L-cysteinyl)-L-glutamic acid." [RESID:AA0315]
subset: gosubset_prok
xref: RESID:AA0315
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018200 ! peptidyl-glutamic acid modification

[Term]
id: GO:0019930
name: cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid peptidyl-aspartate ester biosynthetic process from peptidyl-aspartic acid
namespace: biological_process
def: "The modification of peptidyl-aspartic acid to form peptidyl-cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester, typical of the barley lipid transfer protein 1." [RESID:AA0316]
subset: gosubset_prok
synonym: "cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid peptidyl-aspartate ester anabolism from peptidyl-aspartic acid" EXACT []
synonym: "cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid peptidyl-aspartate ester formation from peptidyl-aspartic acid" EXACT []
synonym: "cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid peptidyl-aspartate ester synthesis from peptidyl-aspartic acid" EXACT []
xref: RESID:AA0316
is_a: GO:0018197 ! peptidyl-aspartic acid modification

[Term]
id: GO:0019931
name: protein-chromophore linkage via peptidyl-N6-3-dehydroretinal-L-lysine
namespace: biological_process
def: "The modification of peptidyl-lysine to form N6-3,4-didehydroretinylidene-L-lysine." [RESID:AA0312]
subset: gosubset_prok
xref: RESID:AA0312
is_a: GO:0018205 ! peptidyl-lysine modification
is_a: GO:0018298 ! protein-chromophore linkage

[Term]
id: GO:0019932
name: second-messenger-mediated signaling
namespace: biological_process
def: "Any intracellular signal transduction in which the signal is passed on within the cell via a second messenger; a small molecule or ion that can be quickly generated or released from intracellular stores, and can diffuse within the cell. Second-messenger signaling includes production or release of the second messenger, and effectors downstream of the second messenger that further transmit the signal within the cell." [GOC:signaling, ISBN:0815316194, PMID:15221855, Wikipedia:Second_messenger_system]
subset: gosubset_prok
synonym: "second messenger mediated signaling" EXACT []
synonym: "second messenger mediated signalling" EXACT []
synonym: "second messenger-mediated signaling" EXACT []
synonym: "second messenger-mediated signalling" EXACT []
synonym: "second-messenger-mediated signal transduction" EXACT [GOC:signaling]
synonym: "second-messenger-mediated signalling" EXACT []
is_a: GO:0035556 ! intracellular signal transduction
relationship: occurs_in GO:0005622 ! intracellular

[Term]
id: GO:0019933
name: cAMP-mediated signaling
namespace: biological_process
def: "Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell." [GOC:signaling]
synonym: "3',5' cAMP-mediated signaling" EXACT []
synonym: "3',5' cAMP-mediated signalling" EXACT []
synonym: "3',5'-cAMP-mediated signaling" EXACT []
synonym: "3',5'-cAMP-mediated signalling" EXACT []
synonym: "adenosine 3',5'-cyclophosphate-mediated signaling" EXACT []
synonym: "adenosine 3',5'-cyclophosphate-mediated signalling" EXACT []
synonym: "cAMP signaling" EXACT []
synonym: "cAMP signalling" EXACT []
synonym: "cAMP-mediated signal transduction" EXACT []
synonym: "cAMP-mediated signalling" EXACT []
synonym: "cyclic AMP-mediated signaling" EXACT []
synonym: "cyclic AMP-mediated signalling" EXACT []
is_a: GO:0019935 ! cyclic-nucleotide-mediated signaling

[Term]
id: GO:0019934
name: cGMP-mediated signaling
namespace: biological_process
def: "Any intracellular signal transduction in which the signal is passed on within the cell via cyclic GMP (cGMP). Includes production of cGMP, and downstream effectors that further transmit the signal within the cell." [GOC:signaling]
synonym: "cGMP-mediated signalling" EXACT []
is_a: GO:0019935 ! cyclic-nucleotide-mediated signaling

[Term]
id: GO:0019935
name: cyclic-nucleotide-mediated signaling
namespace: biological_process
def: "Any intracellular signal transduction in which the signal is passed on within the cell via a cyclic nucleotide. Includes production or release of the cyclic nucleotide, and downstream effectors that further transmit the signal within the cell." [GOC:signaling]
subset: gosubset_prok
synonym: "cyclic-nucleotide-mediated signalling" EXACT []
is_a: GO:0019932 ! second-messenger-mediated signaling

[Term]
id: GO:0019936
name: obsolete inositol phospholipid-mediated signaling
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ceb]
comment: This term was made obsolete because it did not adequately describe phosphoinositide-mediated signaling.
synonym: "inositol phospholipid-mediated signaling" EXACT []
synonym: "inositol phospholipid-mediated signalling" EXACT []
is_obsolete: true
consider: GO:0048016
consider: GO:0048017

[Term]
id: GO:0019937
name: protein catenane formation via N6-(L-isoaspartyl)-L-lysine, autocatalytic
namespace: biological_process
def: "The autocatalytic formation of isopeptide bonds by ligation of peptidyl-lysine and peptidyl-asparagine residues; known to occur in the capsid of some bacteriophage, such as HK97, where it is thought to provide a mechanism for stabilizing the capsid." [RESID:AA0294]
subset: gosubset_prok
xref: RESID:AA0294
is_a: GO:0018419 ! protein catenane formation
is_a: GO:0018420 ! peptide cross-linking via N6-(L-isoaspartyl)-L-lysine

[Term]
id: GO:0019938
name: peptide cross-linking via N6-(L-isoaspartyl)-L-lysine, presumed catalytic
namespace: biological_process
alt_id: GO:0042266
def: "The formation of isopeptide bonds by ligation of peptidyl-lysine and peptidyl-asparagine residues; occurs in mammals in proteins as yet unidentified by a mechanism probably analogous to that of transglutaminase reactions." [RESID:AA0294]
subset: gosubset_prok
xref: RESID:AA0294
is_a: GO:0018420 ! peptide cross-linking via N6-(L-isoaspartyl)-L-lysine

[Term]
id: GO:0019939
name: peptidyl-S-palmitoleyl-L-cysteine biosynthetic process from peptidyl-cysteine
namespace: biological_process
def: "The modification of peptidyl-cysteine to form peptidyl-S-palmitoleyl-L-cysteine specifically." [RESID:AA0308]
subset: gosubset_prok
synonym: "peptidyl-S-palmitoleyl-L-cysteine anabolism from peptidyl-cysteine" EXACT []
synonym: "peptidyl-S-palmitoleyl-L-cysteine formation from peptidyl-cysteine" EXACT []
synonym: "peptidyl-S-palmitoleyl-L-cysteine synthesis from peptidyl-cysteine" EXACT []
xref: RESID:AA0308
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0045234 ! protein palmitoleylation

[Term]
id: GO:0019940
name: obsolete SUMO-dependent protein catabolic process
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it does not reflect an accurate biological process, as sumoylation of a protein does not lead to catabolism of that protein.
synonym: "SUMO-dependent protein breakdown" EXACT []
synonym: "SUMO-dependent protein catabolic process" EXACT []
synonym: "SUMO-dependent protein catabolism" EXACT []
synonym: "SUMO-dependent protein degradation" EXACT []
is_obsolete: true
consider: GO:0016925
consider: GO:0016926

[Term]
id: GO:0019941
name: modification-dependent protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein." [GOC:go_curators]
subset: gosubset_prok
synonym: "modification-dependent protein breakdown" EXACT []
synonym: "modification-dependent protein catabolism" EXACT []
synonym: "modification-dependent protein degradation" EXACT []
synonym: "modification-dependent proteolysis" EXACT [GOC:rl]
synonym: "modification-initiated protein catabolic process" EXACT [GOC:rl]
synonym: "modification-initiated protein catabolism" EXACT [GOC:rl]
synonym: "modification-initiated proteolysis" EXACT [GOC:rl]
synonym: "protein degradation tagging activity" RELATED []
synonym: "protein-ligand-dependent protein catabolic process" NARROW []
synonym: "protein-ligand-dependent protein catabolism" NARROW []
is_a: GO:0043632 ! modification-dependent macromolecule catabolic process
is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process

[Term]
id: GO:0019942
name: obsolete NEDD8 class-dependent protein catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to the target protein." [GOC:jl]
comment: This term was made obsolete because NEDD8-class tags do not target proteins for proteolytic destruction.
synonym: "NEDD8 class-dependent protein breakdown" EXACT []
synonym: "NEDD8 class-dependent protein catabolic process" EXACT []
synonym: "NEDD8 class-dependent protein catabolism" EXACT []
synonym: "NEDD8 class-dependent protein degradation" EXACT []
synonym: "RUB1-dependent protein catabolic process" EXACT []
synonym: "RUB1-dependent protein catabolism" EXACT []
synonym: "RUB1-dependent protein degradation" EXACT []
is_obsolete: true
consider: GO:0045116

[Term]
id: GO:0019948
name: SUMO activating enzyme activity
namespace: molecular_function
alt_id: GO:0017115
def: "Catalysis of the activation of the proteolytically processed small ubiquitin-related modifier SUMO, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:rn, PMID:10187858, PMID:11265250]
synonym: "SMT3 activating enzyme" EXACT []
synonym: "SUMO E1 activator enzyme" EXACT []
is_a: GO:0008641 ! small protein activating enzyme activity

[Term]
id: GO:0019950
name: SMT3-dependent protein catabolic process
namespace: biological_process
alt_id: GO:0019946
def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by covalent attachment of the ubiquitin-like protein SMT3 to the target protein." [GOC:jl, PMID:9435231]
synonym: "SMT3-dependent protein breakdown" EXACT []
synonym: "SMT3-dependent protein catabolism" EXACT []
synonym: "SMT3-dependent protein degradation" EXACT []
is_a: GO:0019941 ! modification-dependent protein catabolic process

[Term]
id: GO:0019951
name: Smt3-protein conjugation
namespace: biological_process
alt_id: GO:0019947
def: "The covalent addition to a protein of Smt3, a ubiquitin-like protein." [GOC:jl]
synonym: "Smt3p-protein conjugation" EXACT []
is_a: GO:0032446 ! protein modification by small protein conjugation
relationship: part_of GO:0019950 ! SMT3-dependent protein catabolic process

[Term]
id: GO:0019953
name: sexual reproduction
namespace: biological_process
def: "A reproduction process that creates a new organism by combining the genetic material of two organisms. It occurs both in eukaryotes and prokaryotes: in multicellular eukaryotic organisms, an individual is created anew; in prokaryotes, the initial cell has additional or transformed genetic material. In a process called genetic recombination, genetic material (DNA) originating from two different individuals (parents) join up so that homologous sequences are aligned with each other, and this is followed by exchange of genetic information. After the new recombinant chromosome is formed, it is passed on to progeny." [GOC:jl, http://en.wikipedia.org/wiki/Sexual_reproduction, ISBN:0387520546]
comment: Sexual reproduction may be seen as the regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times.
xref: Wikipedia:Sexual_reproduction
is_a: GO:0000003 ! reproduction
is_a: GO:0044703 ! multi-organism reproductive process

[Term]
id: GO:0019954
name: asexual reproduction
namespace: biological_process
def: "The biological process in which new individuals are produced by either a single cell or a group of cells, in the absence of any sexual process." [ISBN:0387520546]
subset: gosubset_prok
xref: Wikipedia:Asexual_reproduction
is_a: GO:0000003 ! reproduction

[Term]
id: GO:0019955
name: cytokine binding
namespace: molecular_function
alt_id: GO:0019965
def: "Interacting selectively and non-covalently with a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity." [GOC:ai, GOC:bf, ISBN:0198599471]
synonym: "IL binding" NARROW []
synonym: "interleukin binding" NARROW []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0019956
name: chemokine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a chemokine. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria." [GOC:ai, GOC:BHF, GOC:rl, http://en.wikipedia.org/wiki/Chemokine, PMID:12183377]
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0019957
name: C-C chemokine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a C-C chemokine; C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif." [GOC:ai]
is_a: GO:0019956 ! chemokine binding

[Term]
id: GO:0019958
name: C-X-C chemokine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a C-X-C chemokine; C-X-C chemokines have a single amino acid between the first two cysteines of the characteristic four cysteine motif." [GOC:ai]
is_a: GO:0019956 ! chemokine binding

[Term]
id: GO:0019959
name: interleukin-8 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-8." [GOC:jl]
synonym: "IL-8 binding" EXACT []
is_a: GO:0019958 ! C-X-C chemokine binding

[Term]
id: GO:0019960
name: C-X3-C chemokine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a C-X3-C chemokine; C-X3-C chemokines have three amino acids between the first two cysteines of the characteristic four-cysteine motif." [GOC:ai]
is_a: GO:0019956 ! chemokine binding

[Term]
id: GO:0019961
name: interferon binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an interferon, a protein produced by the immune systems of many animals in response to a challenge by a foreign agent." [PMID:9607096, Wikipedia:Interferon]
synonym: "IFN binding" EXACT [GOC:mah]
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0019962
name: type I interferon binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type I interferon. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16681834]
synonym: "interferon-alpha binding" NARROW []
synonym: "interferon-alpha/beta binding" NARROW []
synonym: "interferon-beta binding" NARROW []
synonym: "interferon-delta binding" NARROW []
synonym: "interferon-epsilon binding" NARROW []
synonym: "interferon-kappa binding" NARROW []
synonym: "interferon-omega binding" NARROW []
synonym: "interferon-tau binding" NARROW []
synonym: "interferon-zeta binding" NARROW []
synonym: "type I IFN binding" EXACT [GOC:mah]
is_a: GO:0019961 ! interferon binding

[Term]
id: GO:0019964
name: interferon-gamma binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interferon-gamma. Interferon gamma is the only member of the type II interferon found so far." [GOC:add, GOC:ai, ISBN:0126896631, PMID:15546383, PR:000000017]
synonym: "IFN-gamma binding" EXACT [GOC:mah, PR:000000017]
synonym: "IFNG binding" EXACT [GOC:mah]
synonym: "type II interferon binding" BROAD [PMID:15546383, PR:000024990]
is_a: GO:0019961 ! interferon binding

[Term]
id: GO:0019966
name: interleukin-1 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-1." [GOC:jl, ISBN:0198506732]
synonym: "IL-1 binding" EXACT []
is_a: GO:0019838 ! growth factor binding
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0019969
name: interleukin-10 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-10." [GOC:jl]
synonym: "IL-10 binding" EXACT []
is_a: GO:0019838 ! growth factor binding
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0019970
name: interleukin-11 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-11." [GOC:jl]
synonym: "IL-11 binding" EXACT []
is_a: GO:0019838 ! growth factor binding
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0019972
name: interleukin-12 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-12." [GOC:jl]
synonym: "IL-12 binding" EXACT []
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0019973
name: interleukin-13 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-13." [GOC:jl]
synonym: "IL-13 binding" EXACT []
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0019974
name: interleukin-14 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-14." [GOC:jl]
synonym: "IL-14 binding" EXACT []
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0019975
name: interleukin-17 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any member of the interleukin-17 family of cytokines." [GOC:add, GOC:jl]
synonym: "IL-17 binding" EXACT []
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0019976
name: interleukin-2 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-2." [GOC:jl]
synonym: "IL-2 binding" EXACT []
is_a: GO:0019838 ! growth factor binding
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0019977
name: interleukin-21 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-21." [GOC:jl]
synonym: "IL-21 binding" EXACT []
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0019978
name: interleukin-3 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-3." [GOC:jl]
synonym: "IL-3 binding" EXACT []
is_a: GO:0019838 ! growth factor binding
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0019979
name: interleukin-4 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-4." [GOC:jl]
synonym: "IL-4 binding" EXACT []
is_a: GO:0019838 ! growth factor binding
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0019980
name: interleukin-5 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-5." [GOC:jl]
synonym: "IL-5 binding" EXACT []
is_a: GO:0019838 ! growth factor binding
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0019981
name: interleukin-6 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-6." [GOC:jl]
synonym: "IL-6 binding" EXACT []
is_a: GO:0019838 ! growth factor binding
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0019982
name: interleukin-7 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-7." [GOC:jl]
synonym: "IL-7 binding" EXACT []
is_a: GO:0019838 ! growth factor binding
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0019983
name: interleukin-9 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-9." [GOC:jl]
synonym: "IL-9 binding" EXACT []
is_a: GO:0019838 ! growth factor binding
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0019985
name: translesion synthesis
namespace: biological_process
def: "The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide." [GOC:elh, GOC:vw, PMID:10535901]
subset: gosubset_prok
synonym: "bypass DNA synthesis" EXACT [GOC:elh]
xref: Reactome:REACT_115598 "DNA damage bypass, Gallus gallus"
xref: Reactome:REACT_115640 "Translesion synthesis by Pol kappa, Gallus gallus"
xref: Reactome:REACT_115864 "Translesion synthesis by Pol eta, Gallus gallus"
xref: Reactome:REACT_115941 "Translesion synthesis by DNA polymerases bypassing lesion on DNA template, Gallus gallus"
xref: Reactome:REACT_116049 "RAD18 and ubiquitinated PCNA-mediated recruitment of translesion polymerases, Gallus gallus"
xref: Reactome:REACT_116052 "Translesion synthesis by Pol zeta, Gallus gallus"
is_a: GO:0000731 ! DNA synthesis involved in DNA repair
is_a: GO:0006301 ! postreplication repair
is_a: GO:0044711 ! single-organism biosynthetic process

[Term]
id: GO:0019987
name: obsolete negative regulation of anti-apoptosis
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of anti-apoptosis." [GOC:go_curators, GOC:mtg_apoptosis]
comment: This term was made obsolete because it was ill-defined.
synonym: "down regulation of anti-apoptosis" EXACT []
synonym: "down-regulation of anti-apoptosis" EXACT []
synonym: "downregulation of anti-apoptosis" EXACT []
synonym: "inhibition of anti-apoptosis" NARROW []
synonym: "negative regulation of anti-apoptosis" EXACT []
is_obsolete: true

[Term]
id: GO:0019988
name: charged-tRNA amino acid modification
namespace: biological_process
alt_id: GO:0030630
def: "The covalent alteration of an amino acid charged on a tRNA before it is incorporated into a protein, as in N-formylmethionine, selenocysteine or pyrrolysine." [GOC:jsg]
subset: gosubset_prok
synonym: "charged tRNA amino acid modification" EXACT []
synonym: "charged tRNA modification" EXACT []
synonym: "charged-tRNA modification" RELATED []
synonym: "pre-translational amino acid modification" EXACT []
synonym: "pre-translational protein modification" EXACT []
synonym: "pretranslation protein modification" EXACT []
synonym: "pretranslational amino acid modification" EXACT []
is_a: GO:0006400 ! tRNA modification
is_a: GO:0006464 ! cellular protein modification process

[Term]
id: GO:0019990
name: pteridine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group." [ISBN:0198506732]
subset: gosubset_prok
synonym: "pteridine breakdown" EXACT []
synonym: "pteridine catabolism" EXACT []
synonym: "pteridine degradation" EXACT []
is_a: GO:0019889 ! pteridine metabolic process
is_a: GO:0042560 ! pteridine-containing compound catabolic process

[Term]
id: GO:0019991
name: septate junction assembly
namespace: biological_process
def: "The assembly of a septate junction, an intercellular junction found in invertebrate epithelia that is characterized by a ladder like appearance in electron micrographs and thought to provide structural strength and to provide a barrier to diffusion of solutes through the intercellular space." [GOC:ai, PMID:5272312]
is_a: GO:0007043 ! cell-cell junction assembly
relationship: part_of GO:0043297 ! apical junction assembly

[Term]
id: GO:0019992
name: diacylglycerol binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with diacylglycerol, a diester of glycerol and two fatty acids." [GOC:ma]
is_a: GO:0008289 ! lipid binding

[Term]
id: GO:0020002
name: host cell plasma membrane
namespace: cellular_component
def: "The plasma membrane surrounding a host cell." [GOC:mb]
subset: gosubset_prok
is_a: GO:0033644 ! host cell membrane

[Term]
id: GO:0020003
name: symbiont-containing vacuole
namespace: cellular_component
def: "Membrane-bounded vacuole within a host cell in which a symbiont organism resides. The vacuole membrane is derived from both the host and symbiont." [GOC:jl, GOC:mb]
comment: Note that this term does not have a relationship to 'vacuole ; GO:0005773' because it does not fit the definition of a vacuole; the parasitophorous vacuole was so named because it resembles a vacuole in the microscope.
synonym: "parasitophorous vacuole" EXACT []
is_a: GO:0033655 ! host cell cytoplasm part
is_a: GO:0065010 ! extracellular membrane-bounded organelle

[Term]
id: GO:0020004
name: symbiont-containing vacuolar space
namespace: cellular_component
def: "The space between a symbiont plasma membrane and the symbiont-containing vacuole membrane." [GOC:jl, GOC:mb]
synonym: "parasitophorous vacuolar space" EXACT []
synonym: "symbiont-containing vacuole space" RELATED []
is_a: GO:0033643 ! host cell part
is_a: GO:0044421 ! extracellular region part
is_a: GO:0044422 ! organelle part
relationship: part_of GO:0020003 ! symbiont-containing vacuole

[Term]
id: GO:0020005
name: symbiont-containing vacuole membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a symbiont-containing vacuole, derived from both the host and symbiont." [GOC:jl, GOC:mb]
synonym: "parasitophorous vacuolar membrane" EXACT []
is_a: GO:0033643 ! host cell part
is_a: GO:0044421 ! extracellular region part
is_a: GO:0044422 ! organelle part
relationship: part_of GO:0020003 ! symbiont-containing vacuole

[Term]
id: GO:0020006
name: symbiont-containing vacuolar membrane network
namespace: cellular_component
def: "Tubular network of extensions from the symbiont-containing vacuole membrane that protrude into the host cytoplasm." [GOC:jl, PMID:3528173]
synonym: "parasitophorous vacuolar membrane network" EXACT []
synonym: "symbiont-containing vacuole membrane network" EXACT []
synonym: "tubulovesicular network" NARROW []
is_a: GO:0033643 ! host cell part
is_a: GO:0044421 ! extracellular region part
is_a: GO:0044422 ! organelle part
relationship: part_of GO:0020005 ! symbiont-containing vacuole membrane

[Term]
id: GO:0020007
name: apical complex
namespace: cellular_component
def: "A group of cytoskeletal structures and associated membrane-bounded organelles found at the anterior end of adult obligate intracellular protozoan parasites in the phylum Apicomplexa. The apical complex is involved in attachment to and penetration of the host cell, and in parasite proliferation." [GOC:giardia, GOC:mb, PMID:16518471]
is_a: GO:0044464 ! cell part
relationship: part_of GO:0045177 ! apical part of cell

[Term]
id: GO:0020008
name: rhoptry
namespace: cellular_component
def: "A large, club-shaped secretory organelle that forms part of the apical complex of an apicomplexan parasite, and consists of a bulbous body and a narrow electron-dense neck that extends through the conoid at the apical tip of the parasite. The rhoptry necks serve as ducts through which the contents of the rhoptries are secreted after attachment to the host has been completed and at the commencement of invasion. Rhoptry proteins function in the biogenesis and host organellar association of the parasitophorous vacuole." [ISBN:0521664470, PMID:11801218, PMID:16002398]
synonym: "paired organelles" RELATED []
synonym: "toxoneme" RELATED []
xref: Wikipedia:Rhoptry
is_a: GO:0044464 ! cell part
relationship: part_of GO:0020007 ! apical complex

[Term]
id: GO:0020009
name: microneme
namespace: cellular_component
def: "A small, elongated secretory organelle that forms part of the apical complex, located along the main axis of an apicomplexan parasite cell within the extreme apical region and at the periphery under the inner membrane complex. Of the specialized secretory compartments identified in apicomplexans, micronemes discharge their contents first, during initial contact of the parasite's apical pole with the host cell surface. Micronemal proteins function during parasite attachment and penetration into the target cell." [ISBN:0521664470, PMID:11801218]
synonym: "sarconeme" RELATED []
xref: Wikipedia:Microneme
is_a: GO:0043231 ! intracellular membrane-bounded organelle
relationship: part_of GO:0020007 ! apical complex

[Term]
id: GO:0020010
name: conoid
namespace: cellular_component
def: "A spiral cytoskeletal structure located at the apical end of the apical complex in some apicomplexan parasites. Fibers form a left-handed spiral, and are comprised of tubulin protofilaments organized in a ribbon-like structure that differs from the conventional tubular structure characteristic of microtubules." [GOC:expert_dr, PMID:11901169, PMID:16518471]
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0020007 ! apical complex

[Term]
id: GO:0020011
name: apicoplast
namespace: cellular_component
def: "The plastid organelle found in apicomplexans." [ISBN:0521664470]
xref: Wikipedia:Apicoplast
is_a: GO:0009536 ! plastid

[Term]
id: GO:0020012
name: evasion or tolerance of host immune response
namespace: biological_process
def: "Any process, either active or passive, by which an organism avoids the effects of the host organism's immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mb]
subset: gosubset_prok
synonym: "immune evasion" BROAD []
is_a: GO:0030682 ! evasion or tolerance of host defense response
is_a: GO:0051805 ! evasion or tolerance of immune response of other organism involved in symbiotic interaction
is_a: GO:0052572 ! response to host immune response

[Term]
id: GO:0020013
name: modulation by symbiont of host erythrocyte aggregation
namespace: biological_process
def: "Any process in which a symbiont organism modulates the frequency, rate or extent of erythrocyte aggregation in its host organism, e.g. the binding of parasite-infected erythrocytes to uninfected erythrocytes." [GOC:add, GOC:dgh, GOC:mb, GOC:pr, PMID:19467172, PMID:21305024]
comment: Please note that this term does not refer to the in vitro assay called erythrocyte rosetting.
synonym: "rosetting" EXACT []
xref: Wikipedia:Rosetting
is_a: GO:0034118 ! regulation of erythrocyte aggregation
is_a: GO:0044068 ! modulation by symbiont of host cellular process

[Term]
id: GO:0020014
name: schizogony
namespace: biological_process
def: "Cell division by multiple fission in which nuclei and other organelles in the parent cell divide repeatedly and move to the cell periphery before internal membranes develop around them, producing a large number of daughter cells simultaneously." [GOC:mb]
xref: Wikipedia:Protozoal_merogony
is_a: GO:0051301 ! cell division

[Term]
id: GO:0020015
name: glycosome
namespace: cellular_component
def: "A membrane-bounded organelle found in organisms from the order Kinetoplastida that houses the enzymes of glycolysis." [GOC:mb]
subset: goslim_pir
xref: Wikipedia:Glycosome
is_a: GO:0005777 ! peroxisome

[Term]
id: GO:0020016
name: ciliary pocket
namespace: cellular_component
def: "Invagination of the plasma membrane from which a cilium (also called flagellum) protrudes." [GOC:cilia, GOC:mb]
comment: Note that cilia and eukaryotic flagella are deemed to be equivalent. In this case community usage is mostly 'flagellar', but the primary term name reflects the cilium parentage.
synonym: "cilial pocket" EXACT []
synonym: "cilium pocket" EXACT []
synonym: "flagellar pocket" EXACT []
is_a: GO:0044441 ! ciliary part

[Term]
id: GO:0020018
name: ciliary pocket membrane
namespace: cellular_component
def: "That part of the plasma membrane found in the ciliary pocket (also called flagellar pocket)." [GOC:cilia, GOC:mb]
comment: Note that cilia and eukaryotic flagella are deemed to be equivalent. In this case community usage is mostly 'flagellar', but the primary term name reflects the cilium parentage.
synonym: "cilial pocket membrane" EXACT []
synonym: "cilium pocket membrane" EXACT []
synonym: "flagellar pocket membrane" EXACT []
is_a: GO:0060170 ! ciliary membrane
relationship: part_of GO:0020016 ! ciliary pocket

[Term]
id: GO:0020020
name: food vacuole
namespace: cellular_component
alt_id: GO:0005772
def: "Vacuole within a parasite used for digestion of the host cell cytoplasm. An example of this component is found in the Apicomplexa." [GOC:mb]
synonym: "digestive vacuole" EXACT []
is_a: GO:0032010 ! phagolysosome

[Term]
id: GO:0020021
name: immortalization of host cell
namespace: biological_process
def: "The modification of a host cell into an immortal cell line as a consequence of infection. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mb]
synonym: "host cell immortalization" EXACT []
synonym: "host cell transformation" EXACT []
synonym: "transformation of host cell" EXACT []
is_a: GO:0051701 ! interaction with host

[Term]
id: GO:0020022
name: acidocalcisome
namespace: cellular_component
def: "An electron-dense acidic membrane-bounded organelle which contains a matrix of pyrophosphate and polyphosphates with bound calcium and other cations." [GOC:mb]
subset: goslim_pir
synonym: "metachromatic granule" EXACT [PMID:15738951]
synonym: "polyphosphate vacuole" RELATED [PMID:15738951]
synonym: "volutin granule" EXACT [PMID:15738951]
is_a: GO:0043231 ! intracellular membrane-bounded organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0020023
name: kinetoplast
namespace: cellular_component
def: "A sub-structure within the large single mitochondrion of kinetoplastid parasites and which is closely associated with the flagellar pocket and basal body of the flagellum." [GOC:mb]
xref: Wikipedia:Kinetoplast
is_a: GO:0044429 ! mitochondrial part

[Term]
id: GO:0020025
name: subpellicular microtubule
namespace: cellular_component
def: "Singlet microtubules that lie underneath the inner membrane complex and emanate from the basal ring of the conoid." [GOC:mb]
is_a: GO:0005874 ! microtubule
relationship: part_of GO:0020007 ! apical complex

[Term]
id: GO:0020026
name: merozoite dense granule
namespace: cellular_component
def: "Electron-dense organelle with a granular internal matrix found throughout the merozoite life cycle stage of apicomplexan parasites; contains proteins destined to be secreted into the parasitophorous vacuole following parasite invasion of a host cell." [GOC:mb, GOC:mtg_sensu]
synonym: "dense body" RELATED []
is_a: GO:0016023 ! cytoplasmic, membrane-bounded vesicle

[Term]
id: GO:0020027
name: hemoglobin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving hemoglobin, including its uptake and utilization." [GOC:go_curators, GOC:jl]
synonym: "haemoglobin metabolic process" EXACT []
synonym: "haemoglobin metabolism" EXACT []
synonym: "hemoglobin metabolism" EXACT []
is_a: GO:0019538 ! protein metabolic process
is_a: GO:0044260 ! cellular macromolecule metabolic process

[Term]
id: GO:0020028
name: hemoglobin import
namespace: biological_process
def: "The directed movement into a tissue, cell or organelle of externally available hemoglobin." [GOC:mb]
synonym: "haemoglobin uptake" EXACT []
synonym: "hemoglobin uptake" EXACT []
is_a: GO:0017038 ! protein import

[Term]
id: GO:0020030
name: infected host cell surface knob
namespace: cellular_component
def: "Protrusion that develops in the plasma membrane of a parasitized erythrocyte. An example of this component is found in Plasmodium species." [GOC:mb]
is_a: GO:0033655 ! host cell cytoplasm part

[Term]
id: GO:0020031
name: polar ring of apical complex
namespace: cellular_component
def: "An electron dense ring at the most anterior position of the apical complex, from which the conoid fibers originate; formed during an invasive life cycle stage of an apicomplexan parasite." [GOC:mb, PMID:16518471]
synonym: "anterior polar ring of apical complex" EXACT []
synonym: "upper polar ring of apical complex" EXACT []
is_a: GO:0044464 ! cell part
relationship: part_of GO:0020007 ! apical complex

[Term]
id: GO:0020032
name: basal ring of apical complex
namespace: cellular_component
def: "An electron dense ring at the most posterior position of the apical complex, from which the subpellicular microtubules originate; formed during an invasive life cycle stage of an apicomplexan parasite." [GOC:mah, PMID:16518471]
synonym: "lower polar ring of apical complex" EXACT []
synonym: "posterior polar ring of apical complex" EXACT []
synonym: "preconoidal ring of apical complex" EXACT []
is_a: GO:0044464 ! cell part
relationship: part_of GO:0020007 ! apical complex

[Term]
id: GO:0020033
name: antigenic variation
namespace: biological_process
alt_id: GO:0020034
def: "Any process involved in the biological strategy of changing antigenic determinants on the surface that are exposed to another organism's immune system." [GOC:mb]
subset: gosubset_prok
synonym: "surface antigen variation" NARROW []
xref: Wikipedia:Antigenic_variation
is_a: GO:0051809 ! passive evasion of immune response of other organism involved in symbiotic interaction

[Term]
id: GO:0020035
name: cytoadherence to microvasculature, mediated by symbiont protein
namespace: biological_process
def: "The adherence of symbiont-infected erythrocytes to microvascular endothelium via symbiont proteins embedded in the membrane of the erythrocyte." [GOC:mb]
synonym: "cytoadherence to microvasculature, mediated by parasite protein" NARROW []
synonym: "cytoadherence to microvasculature, mediated by symbiont protein" BROAD []
synonym: "parasite-protein-mediated cytoadherence to microvasculature" EXACT []
synonym: "symbiont-protein-mediated cytoadherence to microvasculature" BROAD []
is_a: GO:0044406 ! adhesion of symbiont to host

[Term]
id: GO:0020036
name: Maurer's cleft
namespace: cellular_component
def: "A disk-like structure that appears at the periphery of a red blood cell infected by an apicomplexan parasite, characterized by a translucent lumen and an electron-dense coat of variable thickness; often appears to be tethered to the host cell membrane by fibrous connections with the erythrocyte cytoskeleton." [PMID:16705161]
synonym: "Maurers cleft" EXACT []
is_a: GO:0033655 ! host cell cytoplasm part

[Term]
id: GO:0020037
name: heme binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
subset: gosubset_prok
synonym: "haem binding" EXACT []
is_a: GO:0046906 ! tetrapyrrole binding

[Term]
id: GO:0020038
name: subpellicular network
namespace: cellular_component
def: "A mechanically stable cytoskeletal structure associated with the cytoplasmic face of the pellicle and surrounding the microtubule-based cytoskeleton." [PMID:11420112]
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0020039 ! pellicle

[Term]
id: GO:0020039
name: pellicle
namespace: cellular_component
def: "The structure enclosing an apicomplexan parasite cell; consists of the cell membrane with its associated infrastructure of microtubules, microfilaments and other organelles." [GOC:mah, GOC:mb]
is_a: GO:0044464 ! cell part

[Term]
id: GO:0021501
name: prechordal plate formation
namespace: biological_process
def: "The formation of the prechordal plate. The prechordal plate is a thickening of the endoderm at the cranial end of the primitive streak formed by the involution of Spemann's organizer cells. The prechordal plate and the notochord induce the formation of the neural plate from the overlying ectodermal cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0007399 ! nervous system development

[Term]
id: GO:0021502
name: neural fold elevation formation
namespace: biological_process
def: "The process in which the lateral borders of the neural plate begin to migrate upwards to form the neural folds, caused by the proliferation of the underlying mesoderm." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15806586]
comment: This term was added by GO_REF:0000021.
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0001842 ! neural fold formation

[Term]
id: GO:0021503
name: neural fold bending
namespace: biological_process
def: "The morphogenesis of the neural fold elevations that results in the movement of the tips of the elevations towards each other in order to fuse." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15806586]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0060571 ! morphogenesis of an epithelial fold
relationship: part_of GO:0001842 ! neural fold formation

[Term]
id: GO:0021504
name: neural fold hinge point formation
namespace: biological_process
def: "The formation of the median and lateral hinge points in the neural folds. These are created by apical constriction and basal expansion of the underlying neural cells. The median hinge point extends for the entire length of the neural tube, and the lateral hinge points do not form in the spinal cord region of the neural tube." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:13679871, PMID:15806586]
comment: This term was added by GO_REF:0000021.
synonym: "neural fold furrowing" NARROW [GOC:cls]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021503 ! neural fold bending

[Term]
id: GO:0021505
name: neural fold folding
namespace: biological_process
def: "The process of folding the neuroepithelium around the medial hinge point to create the neural elevations, and around the lateral hinge points to produce convergence of the folds." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:13679871, PMID:15806586]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0060571 ! morphogenesis of an epithelial fold
relationship: part_of GO:0021503 ! neural fold bending

[Term]
id: GO:0021506
name: anterior neuropore closure
namespace: biological_process
def: "The joining together of the neural folds of the rostral opening of the neural tube. The anterior neuropore appears before the process of neural tube closure is complete." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
relationship: part_of GO:0021995 ! neuropore closure

[Term]
id: GO:0021507
name: posterior neuropore closure
namespace: biological_process
def: "The joining together of the neural folds of the caudal opening of the neural tube. The posterior neuropore appears before the process of neural tube closure is complete." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
is_a: GO:0060608 ! cell-cell adhesion involved in neural tube closure
relationship: part_of GO:0021995 ! neuropore closure

[Term]
id: GO:0021508
name: floor plate formation
namespace: biological_process
def: "The formation of a ventral region of glial cells in the neural tube that provides inductive signals for the specification of neuronal cell types. The floor plate is evident at the ventral midline by the neural fold stage." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869]
comment: This term was added by GO_REF:0000021.
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0007418 ! ventral midline development
relationship: part_of GO:0033505 ! floor plate morphogenesis

[Term]
id: GO:0021509
name: roof plate formation
namespace: biological_process
def: "The formation of a single row of glia at the dorsal midline of the developing neural tube. This region provides inductive signals for the specification of neuronal cell types and of the specification of neural crest cells. The cells comprising the roof plate are the precursors to radial glial cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15936325]
comment: This term was added by GO_REF:0000021.
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0001841 ! neural tube formation

[Term]
id: GO:0021510
name: spinal cord development
namespace: biological_process
def: "The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048513 ! animal organ development
relationship: part_of GO:0007417 ! central nervous system development

[Term]
id: GO:0021511
name: spinal cord patterning
namespace: biological_process
def: "The regionalization process that regulates the coordinated growth and establishes the non-random spatial arrangement of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0021510 ! spinal cord development

[Term]
id: GO:0021512
name: spinal cord anterior/posterior patterning
namespace: biological_process
def: "The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "spinal cord anterior-posterior patterning" EXACT []
synonym: "spinal cord rostrocaudal patterning" RELATED [GOC:dph]
is_a: GO:0009952 ! anterior/posterior pattern specification
relationship: part_of GO:0021511 ! spinal cord patterning

[Term]
id: GO:0021513
name: spinal cord dorsal/ventral patterning
namespace: biological_process
def: "The process that regulates the coordinated growth and differentiation that establishes the non-random dorsal-ventral spatial arrangement of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "spinal cord dorsal-ventral patterning" EXACT []
synonym: "spinal cord dorsoventral patterning" EXACT [GOC:mah]
is_a: GO:0009953 ! dorsal/ventral pattern formation
relationship: part_of GO:0021511 ! spinal cord patterning

[Term]
id: GO:0021514
name: ventral spinal cord interneuron differentiation
namespace: biological_process
def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of ventral spinal cord interneurons. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021515 ! cell differentiation in spinal cord
is_a: GO:0021953 ! central nervous system neuron differentiation
relationship: part_of GO:0021517 ! ventral spinal cord development

[Term]
id: GO:0021515
name: cell differentiation in spinal cord
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869]
comment: This term was added by GO_REF:0000021.
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0021510 ! spinal cord development

[Term]
id: GO:0021516
name: dorsal spinal cord development
namespace: biological_process
def: "The process whose specific outcome is the progression of the dorsal region of the spinal cord over time, from its formation to the mature structure. The dorsal region of the mature spinal cord contains neurons that process and relay sensory input." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11179871]
comment: This term was added by GO_REF:0000021.
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021510 ! spinal cord development

[Term]
id: GO:0021517
name: ventral spinal cord development
namespace: biological_process
def: "The process whose specific outcome is the progression of the ventral region of the spinal cord over time, from its formation to the mature structure. The neurons of the ventral region of the mature spinal cord participate in motor output." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021510 ! spinal cord development

[Term]
id: GO:0021518
name: spinal cord commissural neuron specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a commissural neuron in an environment that is neutral with respect to the developmental pathway." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048665 ! neuron fate specification
relationship: part_of GO:0021528 ! commissural neuron differentiation in spinal cord

[Term]
id: GO:0021519
name: spinal cord association neuron specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into an association neuron in an environment that is neutral with respect to the developmental pathway." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048665 ! neuron fate specification
relationship: part_of GO:0021527 ! spinal cord association neuron differentiation

[Term]
id: GO:0021520
name: spinal cord motor neuron cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a motor neuron in an environment that is neutral with respect to the developmental pathway." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048665 ! neuron fate specification
relationship: part_of GO:0021522 ! spinal cord motor neuron differentiation

[Term]
id: GO:0021521
name: ventral spinal cord interneuron specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a ventral spinal cord interneuron in an environment that is neutral with respect to the developmental pathway." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048665 ! neuron fate specification
is_a: GO:0060573 ! cell fate specification involved in pattern specification
relationship: part_of GO:0060579 ! ventral spinal cord interneuron fate commitment

[Term]
id: GO:0021522
name: spinal cord motor neuron differentiation
namespace: biological_process
def: "The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021515 ! cell differentiation in spinal cord
is_a: GO:0021953 ! central nervous system neuron differentiation
relationship: part_of GO:0021517 ! ventral spinal cord development

[Term]
id: GO:0021523
name: somatic motor neuron differentiation
namespace: biological_process
def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of somatic motor neurons. Somatic motor neurons innervate skeletal muscle targets and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021522 ! spinal cord motor neuron differentiation

[Term]
id: GO:0021524
name: visceral motor neuron differentiation
namespace: biological_process
def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of visceral motor neurons. Visceral motor neurons innervate glandular targets and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021522 ! spinal cord motor neuron differentiation

[Term]
id: GO:0021525
name: lateral motor column neuron differentiation
namespace: biological_process
def: "The process in which differentiating motor neurons in the neural tube acquire the specialized structural and/or functional features of lateral motor column neurons. Lateral motor column neurons are generated only on limb levels and send axons into the limb mesenchyme. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021522 ! spinal cord motor neuron differentiation
relationship: part_of GO:0021523 ! somatic motor neuron differentiation

[Term]
id: GO:0021526
name: medial motor column neuron differentiation
namespace: biological_process
def: "The process in which differentiating motor neurons in the neural tube acquire the specialized structural and/or functional features of medial motor column neurons. Medial motor column neurons are generated at all rostrocaudal levels and send axons to the axial muscles (medial group) and to the body wall muscles (lateral group). Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021515 ! cell differentiation in spinal cord
is_a: GO:0030182 ! neuron differentiation
relationship: part_of GO:0021523 ! somatic motor neuron differentiation

[Term]
id: GO:0021527
name: spinal cord association neuron differentiation
namespace: biological_process
def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of association neurons. Association neurons are cells located in the dorsal portion of the spinal cord that integrate sensory input. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869]
comment: This term was added by GO_REF:0000021.
synonym: "spinal cord dorsal interneuron differentiation" EXACT [GOC:dph]
is_a: GO:0021515 ! cell differentiation in spinal cord
is_a: GO:0021953 ! central nervous system neuron differentiation
relationship: part_of GO:0021516 ! dorsal spinal cord development

[Term]
id: GO:0021528
name: commissural neuron differentiation in spinal cord
namespace: biological_process
def: "The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of commissural neurons. Commissural neurons in both vertebrates and invertebrates transfer information from one side of their bodies to the other through the midline. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021515 ! cell differentiation in spinal cord
is_a: GO:0021953 ! central nervous system neuron differentiation

[Term]
id: GO:0021529
name: spinal cord oligodendrocyte cell differentiation
namespace: biological_process
def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of oligodendrocytes. Oligodendrocytes are non-neuronal cells. The primary function of oligodendrocytes is the myelination of nerve axons in the central nervous system. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021515 ! cell differentiation in spinal cord
is_a: GO:0048709 ! oligodendrocyte differentiation

[Term]
id: GO:0021530
name: spinal cord oligodendrocyte cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into an oligodendrocyte in an environment that is neutral with respect to the developmental pathway." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021778 ! oligodendrocyte cell fate specification
relationship: part_of GO:0021529 ! spinal cord oligodendrocyte cell differentiation

[Term]
id: GO:0021531
name: spinal cord radial glial cell differentiation
namespace: biological_process
def: "The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of radial glial cells. Radial cell precursors differentiate into both neuronal cell types and mature radial glial cells. Mature radial glial cells regulate the axon growth and pathfinding processes that occur during white matter patterning of the developing spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16185248]
comment: This term was added by GO_REF:0000021.
synonym: "radial glial cell differentiation in spinal cord" EXACT [GOC:curators]
is_a: GO:0021515 ! cell differentiation in spinal cord
is_a: GO:0060019 ! radial glial cell differentiation

[Term]
id: GO:0021532
name: neural tube patterning
namespace: biological_process
def: "The regionalization process that regulates the coordinated growth that establishes the non-random spatial arrangement of the neural tube." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0021915 ! neural tube development

[Term]
id: GO:0021533
name: cell differentiation in hindbrain
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mature cells of the hindbrain. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0030902 ! hindbrain development

[Term]
id: GO:0021534
name: cell proliferation in hindbrain
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population in the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0061351 ! neural precursor cell proliferation
relationship: part_of GO:0030902 ! hindbrain development

[Term]
id: GO:0021535
name: cell migration in hindbrain
namespace: biological_process
def: "The orderly movement of a cell that will reside in the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0016477 ! cell migration
relationship: part_of GO:0030902 ! hindbrain development

[Term]
id: GO:0021536
name: diencephalon development
namespace: biological_process
def: "The process whose specific outcome is the progression of the diencephalon over time, from its formation to the mature structure. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0030900 ! forebrain development

[Term]
id: GO:0021537
name: telencephalon development
namespace: biological_process
def: "The process whose specific outcome is the progression of the telencephalon over time, from its formation to the mature structure. The telencephalon is the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "cerebrum development" EXACT [GOC:sl, PMID:22331407]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0030900 ! forebrain development

[Term]
id: GO:0021538
name: epithalamus development
namespace: biological_process
def: "The progression of the epithalamus over time from its initial formation until its mature state. The epithalamus is the small dorsomedial area of the thalamus including the habenular nuclei and associated fiber bundles, the pineal body, and the epithelial roof of the third ventricle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021536 ! diencephalon development

[Term]
id: GO:0021539
name: subthalamus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the subthalamus over time, from its formation to the mature structure. The subthalamus is the anterior part of the diencephalon that lies between the thalamus, hypothalamus, and tegmentum of the mesencephalon, including subthalamic nucleus, zona incerta, the fields of Forel, and the nucleus of ansa lenticularis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "ventral thalamus development" RELATED [GOC:cls]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021536 ! diencephalon development

[Term]
id: GO:0021540
name: corpus callosum morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the corpus callosum are generated and organized. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021952 ! central nervous system projection neuron axonogenesis
relationship: part_of GO:0022038 ! corpus callosum development

[Term]
id: GO:0021541
name: ammon gyrus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the ammon gyrus over time, from its formation to the mature structure. The ammon gyrus, often subdivided into the CA1 and CA3 regions, is one of the two interlocking gyri of the hippocampus that is rich in large pyramidal neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "Ammon's horn development" RELATED [GOC:cls]
synonym: "cornu ammonis development" RELATED [GOC:cls]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021766 ! hippocampus development

[Term]
id: GO:0021542
name: dentate gyrus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the dentate gyrus over time, from its formation to the mature structure. The dentate gyrus is one of two interlocking gyri of the hippocampus. It contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021766 ! hippocampus development

[Term]
id: GO:0021543
name: pallium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pallium over time, from its formation to the mature structure. The pallium is the roof region of the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021537 ! telencephalon development

[Term]
id: GO:0021544
name: subpallium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the subpallium over time, from its formation to the mature structure. The subpallium is the base region of the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021537 ! telencephalon development

[Term]
id: GO:0021545
name: cranial nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cranial nerves over time, from its formation to the mature structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021675 ! nerve development

[Term]
id: GO:0021546
name: rhombomere development
namespace: biological_process
def: "The process whose specific outcome is the progression of the rhombomere over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0030902 ! hindbrain development

[Term]
id: GO:0021547
name: midbrain-hindbrain boundary initiation
namespace: biological_process
def: "The regionalization process that gives rise to the midbrain-hindbrain boundary. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:isa_complete, GOC:jid, GOC:mtg_15jun06, PMID:15541513]
comment: This term was added by GO_REF:0000021.
synonym: "isthmus biosynthesis" RELATED [GOC:cls]
synonym: "isthmus formation" RELATED [GOC:cls]
synonym: "MHB biosynthesis" EXACT [GOC:cls]
synonym: "MHB formation" EXACT [GOC:cls]
synonym: "midbrain-hindbrain boundary biosynthesis" EXACT [GOC:cls]
synonym: "midbrain-hindbrain boundary formation" EXACT [GOC:cls]
is_a: GO:0003002 ! regionalization
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021999 ! neural plate anterior/posterior regionalization
relationship: part_of GO:0030917 ! midbrain-hindbrain boundary development

[Term]
id: GO:0021548
name: pons development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pons over time, from its formation to the mature structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0022037 ! metencephalon development

[Term]
id: GO:0021549
name: cerebellum development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0022037 ! metencephalon development

[Term]
id: GO:0021550
name: medulla oblongata development
namespace: biological_process
def: "The process whose specific outcome is the progression of the medulla oblongata over time, from its formation to the mature structure. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "medulla development" RELATED [GOC:cls]
synonym: "myelencephalon development" RELATED [GOC:cls]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0030902 ! hindbrain development

[Term]
id: GO:0021551
name: central nervous system morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the central nervous system is generated and organized. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0582227089]
comment: This term was added by GO_REF:0000021.
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0007417 ! central nervous system development

[Term]
id: GO:0021552
name: midbrain-hindbrain boundary structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the midbrain-hindbrain boundary structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15541513]
comment: This term was added by GO_REF:0000021.
synonym: "isthmus structural organization" RELATED [GOC:cls]
synonym: "MHB structural organization" EXACT [GOC:cls]
synonym: "midbrain-hindbrain boundary structural organisation" EXACT [GOC:mah]
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0021555 ! midbrain-hindbrain boundary morphogenesis

[Term]
id: GO:0021553
name: olfactory nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of the olfactory nerve over time, from its formation to the mature structure. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN 1 development" RELATED [GOC:cls]
synonym: "cranial nerve 1 development" EXACT [GOC:cls]
synonym: "cranial nerve I development" EXACT [GOC:cls]
is_a: GO:0021545 ! cranial nerve development

[Term]
id: GO:0021554
name: optic nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of the optic nerve over time, from its formation to the mature structure. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN II development" RELATED [GOC:cls]
synonym: "cranial nerve 2 development" EXACT [GOC:cls]
synonym: "cranial nerve II development" EXACT [GOC:cls]
is_a: GO:0021545 ! cranial nerve development

[Term]
id: GO:0021555
name: midbrain-hindbrain boundary morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the midbrain-hindbrain boundary is generated and organized. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15541513]
comment: This term was added by GO_REF:0000021.
synonym: "isthmus morphogenesis" EXACT [GOC:cls]
synonym: "MHB morphogenesis" EXACT [GOC:cls]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0030917 ! midbrain-hindbrain boundary development

[Term]
id: GO:0021556
name: central nervous system formation
namespace: biological_process
def: "The process that gives rise to the central nervous system. This process pertains to the initial formation of a structure from unspecified parts. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0582227089]
comment: This term was added by GO_REF:0000021.
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021551 ! central nervous system morphogenesis

[Term]
id: GO:0021557
name: oculomotor nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of the oculomotor nerve over time, from its formation to the mature structure. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN III development" RELATED [GOC:cls]
synonym: "cranial nerve 3 development" EXACT [GOC:cls]
synonym: "cranial nerve III development" EXACT [GOC:cls]
is_a: GO:0021545 ! cranial nerve development
relationship: part_of GO:0021783 ! preganglionic parasympathetic fiber development

[Term]
id: GO:0021558
name: trochlear nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of the trochlear nerve over time, from its formation to the mature structure. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN IV development" RELATED [GOC:cls]
synonym: "cranial nerve 4 development" EXACT [GOC:cls]
synonym: "cranial nerve IV development" EXACT [GOC:cls]
is_a: GO:0021545 ! cranial nerve development

[Term]
id: GO:0021559
name: trigeminal nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of the trigeminal nerve over time, from its formation to the mature structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN V development" RELATED [GOC:cls]
synonym: "cranial nerve 5 development" EXACT [GOC:cls]
synonym: "cranial nerve V development" EXACT [GOC:cls]
is_a: GO:0021545 ! cranial nerve development

[Term]
id: GO:0021560
name: abducens nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of the abducens nerve over time, from its formation to the mature structure. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN VI development" RELATED [GOC:cls]
synonym: "cranial nerve 6 development" EXACT [GOC:cls]
synonym: "cranial nerve VI development" EXACT [GOC:cls]
is_a: GO:0021545 ! cranial nerve development

[Term]
id: GO:0021561
name: facial nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of the facial nerve over time, from its formation to the mature structure. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives off nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN VII development" RELATED [GOC:cls]
synonym: "cranial nerve 7 development" EXACT [GOC:cls]
synonym: "cranial nerve VII development" EXACT [GOC:cls]
is_a: GO:0021545 ! cranial nerve development
relationship: part_of GO:0021783 ! preganglionic parasympathetic fiber development

[Term]
id: GO:0021562
name: vestibulocochlear nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of the vestibulocochlear nerve over time, from its formation to the mature structure. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "acoustic nerve development" EXACT [PMID:11533729]
synonym: "CN VIII development" EXACT [GOC:cls]
synonym: "cranial nerve 8 development" EXACT [GOC:cls]
synonym: "cranial nerve VIII development" EXACT [GOC:cls]
is_a: GO:0021545 ! cranial nerve development

[Term]
id: GO:0021563
name: glossopharyngeal nerve development
namespace: biological_process
def: "Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN IX development" RELATED [GOC:cls]
synonym: "cranial nerve 9 development" EXACT [GOC:cls]
synonym: "cranial nerve IX development" EXACT [GOC:cls]
is_a: GO:0021545 ! cranial nerve development

[Term]
id: GO:0021564
name: vagus nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of the vagus nerve over time, from its formation to the mature structure. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN X development" RELATED [GOC:cls]
synonym: "cranial nerve 10 development" RELATED [GOC:cls]
synonym: "cranial nerve X development" EXACT [GOC:cls]
is_a: GO:0021545 ! cranial nerve development
relationship: part_of GO:0021783 ! preganglionic parasympathetic fiber development

[Term]
id: GO:0021565
name: accessory nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of the accessory nerve over time, from its formation to the mature structure. In mice, the spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN XI development" RELATED [GOC:cls]
synonym: "cranial nerve 11 development" RELATED [GOC:cls]
synonym: "cranial nerve XI development" EXACT [GOC:cls]
synonym: "spinal accessory nerve development" EXACT [PMID:11533729]
is_a: GO:0021545 ! cranial nerve development

[Term]
id: GO:0021566
name: hypoglossal nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of the hypoglossal nerve over time, from its formation to the mature structure. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN XII development" RELATED [GOC:cls]
synonym: "cranial nerve 12 development" RELATED [GOC:cls]
synonym: "cranial nerve XII development" EXACT [GOC:cls]
is_a: GO:0021545 ! cranial nerve development

[Term]
id: GO:0021567
name: rhombomere 1 development
namespace: biological_process
def: "The process whose specific outcome is the progression of rhombomere 1 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021546 ! rhombomere development

[Term]
id: GO:0021568
name: rhombomere 2 development
namespace: biological_process
def: "The process whose specific outcome is the progression of rhombomere 2 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021546 ! rhombomere development

[Term]
id: GO:0021569
name: rhombomere 3 development
namespace: biological_process
def: "The process whose specific outcome is the progression of rhombomere 3 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021546 ! rhombomere development

[Term]
id: GO:0021570
name: rhombomere 4 development
namespace: biological_process
def: "The process whose specific outcome is the progression of rhombomere 4 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021546 ! rhombomere development

[Term]
id: GO:0021571
name: rhombomere 5 development
namespace: biological_process
def: "The process whose specific outcome is the progression of rhombomere 5 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021546 ! rhombomere development

[Term]
id: GO:0021572
name: rhombomere 6 development
namespace: biological_process
def: "The process whose specific outcome is the progression of rhombomere 6 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021546 ! rhombomere development

[Term]
id: GO:0021573
name: rhombomere 7 development
namespace: biological_process
def: "The process whose specific outcome is the progression of rhombomere 7 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021546 ! rhombomere development

[Term]
id: GO:0021574
name: rhombomere 8 development
namespace: biological_process
def: "The process whose specific outcome is the progression of rhombomere 8 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021546 ! rhombomere development

[Term]
id: GO:0021575
name: hindbrain morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the hindbrain is generated and organized. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "rhombencephalon morphogenesis" RELATED []
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0030902 ! hindbrain development

[Term]
id: GO:0021576
name: hindbrain formation
namespace: biological_process
def: "The process that gives rise to the hindbrain. This process pertains to the initial formation of a structure from unspecified parts. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021575 ! hindbrain morphogenesis

[Term]
id: GO:0021577
name: hindbrain structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the hindbrain. This process pertains to the physical shaping of a rudimentary structure. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "hindbrain structural organisation" EXACT [GOC:mah]
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0021575 ! hindbrain morphogenesis

[Term]
id: GO:0021578
name: hindbrain maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the hindbrain to attain its fully functional state. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0071695 ! anatomical structure maturation
relationship: part_of GO:0021626 ! central nervous system maturation
relationship: part_of GO:0030902 ! hindbrain development

[Term]
id: GO:0021579
name: medulla oblongata morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the medulla oblongata is generated and organized. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "medulla morphogenesis" RELATED []
synonym: "myelencephalon morphogenesis" RELATED []
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0021550 ! medulla oblongata development
relationship: part_of GO:0021575 ! hindbrain morphogenesis

[Term]
id: GO:0021580
name: medulla oblongata formation
namespace: biological_process
def: "The process that gives rise to the medulla oblongata. This process pertains to the initial formation of a structure from unspecified parts. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "medulla biosynthesis" RELATED []
synonym: "medulla formation" RELATED []
synonym: "myelencephalon biosynthesis" RELATED []
synonym: "myelencephalon formation" RELATED []
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021576 ! hindbrain formation
relationship: part_of GO:0021579 ! medulla oblongata morphogenesis

[Term]
id: GO:0021581
name: medulla oblongata structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the medulla oblongata. This process pertains to the physical shaping of a rudimentary structure. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "medulla oblongata structural organisation" EXACT [GOC:mah]
synonym: "medulla structural maturation" RELATED []
synonym: "myelencephalon structural maturation" RELATED []
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0021577 ! hindbrain structural organization
relationship: part_of GO:0021579 ! medulla oblongata morphogenesis

[Term]
id: GO:0021582
name: medulla oblongata maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the medulla oblongata to attain its fully functional state. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "medulla maturation" RELATED []
synonym: "myelencephalon maturation" RELATED []
is_a: GO:0071695 ! anatomical structure maturation
relationship: part_of GO:0021550 ! medulla oblongata development
relationship: part_of GO:0021578 ! hindbrain maturation

[Term]
id: GO:0021583
name: pons morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the pons is generated and organized. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0021548 ! pons development
relationship: part_of GO:0021575 ! hindbrain morphogenesis

[Term]
id: GO:0021584
name: pons formation
namespace: biological_process
def: "The process that gives rise to the pons. This process pertains to the initial formation of a structure from unspecified parts. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021576 ! hindbrain formation
relationship: part_of GO:0021583 ! pons morphogenesis

[Term]
id: GO:0021585
name: pons structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the pons. This process pertains to the physical shaping of a rudimentary structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "pons structural organisation" EXACT [GOC:mah]
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0021577 ! hindbrain structural organization
relationship: part_of GO:0021583 ! pons morphogenesis

[Term]
id: GO:0021586
name: pons maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the pons to attain its fully functional state. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0071695 ! anatomical structure maturation
relationship: part_of GO:0021548 ! pons development
relationship: part_of GO:0021578 ! hindbrain maturation

[Term]
id: GO:0021587
name: cerebellum morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the cerebellum is generated and organized. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0021549 ! cerebellum development
relationship: part_of GO:0021575 ! hindbrain morphogenesis

[Term]
id: GO:0021588
name: cerebellum formation
namespace: biological_process
def: "The process that gives rise to the cerebellum. This process pertains to the initial formation of a structure from unspecified parts. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021576 ! hindbrain formation
relationship: part_of GO:0021587 ! cerebellum morphogenesis

[Term]
id: GO:0021589
name: cerebellum structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the cerebellum. This process pertains to the physical shaping of a rudimentary structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "cerebellum structural organisation" EXACT [GOC:mah]
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0021577 ! hindbrain structural organization
relationship: part_of GO:0021587 ! cerebellum morphogenesis

[Term]
id: GO:0021590
name: cerebellum maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellum to attain its fully functional state. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0071695 ! anatomical structure maturation
relationship: part_of GO:0021549 ! cerebellum development
relationship: part_of GO:0021578 ! hindbrain maturation

[Term]
id: GO:0021591
name: ventricular system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the brain ventricular system over time, from its formation to the mature structure. The brain ventricular system consists of four communicating cavities within the brain that are continuous with the central canal of the spinal cord. These cavities include two lateral ventricles, the third ventricle and the fourth ventricle. Cerebrospinal fluid fills the ventricles and is produced by the choroid plexus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048731 ! system development
relationship: part_of GO:0007420 ! brain development

[Term]
id: GO:0021592
name: fourth ventricle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the fourth ventricle over time, from its formation to the mature structure. The fourth ventricle is an irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind. It is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0683400078]
comment: This term was added by GO_REF:0000021.
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021591 ! ventricular system development
relationship: part_of GO:0030902 ! hindbrain development

[Term]
id: GO:0021593
name: rhombomere morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the rhombomere is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0021546 ! rhombomere development

[Term]
id: GO:0021594
name: rhombomere formation
namespace: biological_process
def: "The process that gives rise to the rhombomere. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021593 ! rhombomere morphogenesis

[Term]
id: GO:0021595
name: rhombomere structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the rhombomere structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "rhombomere structural organisation" EXACT [GOC:mah]
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0021593 ! rhombomere morphogenesis

[Term]
id: GO:0021597
name: central nervous system structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the central nervous system structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0582227089]
comment: This term was added by GO_REF:0000021.
synonym: "central nervous system structural organisation" EXACT [GOC:mah]
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0021551 ! central nervous system morphogenesis

[Term]
id: GO:0021598
name: abducens nerve morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the abducens nerve is generated and organized. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN VI development" RELATED []
is_a: GO:0021602 ! cranial nerve morphogenesis
relationship: part_of GO:0021560 ! abducens nerve development

[Term]
id: GO:0021599
name: abducens nerve formation
namespace: biological_process
def: "The process that gives rise to the abducens nerve. This process pertains to the initial formation of a structure from unspecified parts. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN VI biosynthesis" RELATED []
synonym: "CN VI formation" RELATED []
is_a: GO:0021603 ! cranial nerve formation
relationship: part_of GO:0021598 ! abducens nerve morphogenesis

[Term]
id: GO:0021600
name: abducens nerve structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the abducens nerve. This process pertains to the physical shaping of a rudimentary structure. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "abducens nerve structural organisation" EXACT [GOC:mah]
synonym: "CN VI structural organization" RELATED []
is_a: GO:0021604 ! cranial nerve structural organization
relationship: part_of GO:0021598 ! abducens nerve morphogenesis

[Term]
id: GO:0021601
name: abducens nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the abducens nerve to attain its fully functional state. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN VI maturation" RELATED []
is_a: GO:0021605 ! cranial nerve maturation
relationship: part_of GO:0021560 ! abducens nerve development

[Term]
id: GO:0021602
name: cranial nerve morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the cranial nerves are generated and organized. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0021545 ! cranial nerve development

[Term]
id: GO:0021603
name: cranial nerve formation
namespace: biological_process
def: "The process that gives rise to the cranial nerves. This process pertains to the initial formation of a structure from unspecified parts. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021602 ! cranial nerve morphogenesis

[Term]
id: GO:0021604
name: cranial nerve structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the cranial nerves. This process pertains to the physical shaping of a rudimentary structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "cranial nerve structural organisation" EXACT [GOC:mah]
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0021602 ! cranial nerve morphogenesis

[Term]
id: GO:0021605
name: cranial nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a cranial nerve to attain its fully functional state. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021682 ! nerve maturation
relationship: part_of GO:0021545 ! cranial nerve development

[Term]
id: GO:0021606
name: accessory nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the accessory nerve to attain its fully functional state. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN XI maturation" RELATED []
synonym: "spinal accessory nerve maturation" RELATED []
is_a: GO:0021605 ! cranial nerve maturation
relationship: part_of GO:0021565 ! accessory nerve development

[Term]
id: GO:0021607
name: accessory nerve morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the accessory nerve is generated and organized. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN XI morphogenesis" RELATED []
is_a: GO:0021602 ! cranial nerve morphogenesis
relationship: part_of GO:0021565 ! accessory nerve development

[Term]
id: GO:0021608
name: accessory nerve formation
namespace: biological_process
def: "The process that gives rise to the accessory nerve. This process pertains to the initial formation of a structure from unspecified parts. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN XI biosynthesis" RELATED []
synonym: "CN XI formation" RELATED []
is_a: GO:0021603 ! cranial nerve formation
relationship: part_of GO:0021607 ! accessory nerve morphogenesis

[Term]
id: GO:0021609
name: accessory nerve structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the accessory nerve This process pertains to the physical shaping of a rudimentary structure. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "accessory nerve structural organisation" EXACT [GOC:mah]
synonym: "CN XI structural organization" RELATED []
is_a: GO:0021604 ! cranial nerve structural organization
relationship: part_of GO:0021607 ! accessory nerve morphogenesis

[Term]
id: GO:0021610
name: facial nerve morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the facial nerve is generated and organized. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN VII morphogenesis" RELATED []
is_a: GO:0021602 ! cranial nerve morphogenesis
relationship: part_of GO:0021561 ! facial nerve development

[Term]
id: GO:0021611
name: facial nerve formation
namespace: biological_process
def: "The process that gives rise to the facial nerve. This process pertains to the initial formation of a structure from unspecified parts. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN VII biosynthesis" RELATED []
synonym: "CN VII formation" RELATED []
is_a: GO:0021603 ! cranial nerve formation
relationship: part_of GO:0021610 ! facial nerve morphogenesis

[Term]
id: GO:0021612
name: facial nerve structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the facial nerve. This process pertains to the physical shaping of a rudimentary structure. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN VII structural organization" RELATED []
synonym: "facial nerve structural organisation" EXACT [GOC:mah]
is_a: GO:0021604 ! cranial nerve structural organization
relationship: part_of GO:0021610 ! facial nerve morphogenesis

[Term]
id: GO:0021613
name: facial nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the facial nerve to attain its fully functional state. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN VII maturation" RELATED []
is_a: GO:0021605 ! cranial nerve maturation
relationship: part_of GO:0021561 ! facial nerve development

[Term]
id: GO:0021614
name: glossopharyngeal nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the glossopharyngeal nerve to attain its fully functional state. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN IX maturation" RELATED []
is_a: GO:0021605 ! cranial nerve maturation
relationship: part_of GO:0021563 ! glossopharyngeal nerve development

[Term]
id: GO:0021615
name: glossopharyngeal nerve morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the glossopharyngeal nerve is generated and organized. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN IX morphogenesis" RELATED []
is_a: GO:0021602 ! cranial nerve morphogenesis
relationship: part_of GO:0021563 ! glossopharyngeal nerve development

[Term]
id: GO:0021616
name: glossopharyngeal nerve formation
namespace: biological_process
def: "The process that gives rise to the glossopharyngeal nerve. This process pertains to the initial formation of a structure from unspecified parts. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN IX biosynthesis" RELATED []
synonym: "CN IX formation" RELATED []
is_a: GO:0021603 ! cranial nerve formation
relationship: part_of GO:0021615 ! glossopharyngeal nerve morphogenesis

[Term]
id: GO:0021617
name: glossopharyngeal nerve structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the glossopharyngeal nerve. This process pertains to the physical shaping of a rudimentary structure. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN IX structural organization" RELATED []
synonym: "glossopharyngeal nerve structural organisation" EXACT [GOC:mah]
is_a: GO:0021604 ! cranial nerve structural organization
relationship: part_of GO:0021615 ! glossopharyngeal nerve morphogenesis

[Term]
id: GO:0021618
name: hypoglossal nerve morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the hypoglossal nerve is generated and organized. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN XII morphogenesis" RELATED []
is_a: GO:0021602 ! cranial nerve morphogenesis
relationship: part_of GO:0021566 ! hypoglossal nerve development

[Term]
id: GO:0021619
name: hypoglossal nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the hypoglossal nerve to attain its fully functional state. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN XII maturation" RELATED []
is_a: GO:0021605 ! cranial nerve maturation
relationship: part_of GO:0021566 ! hypoglossal nerve development

[Term]
id: GO:0021620
name: hypoglossal nerve formation
namespace: biological_process
def: "The process that gives rise to the hypoglossal nerve. This process pertains to the initial formation of a structure from unspecified parts. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN XII biosynthesis" RELATED []
synonym: "CN XII formation" RELATED []
is_a: GO:0021603 ! cranial nerve formation
relationship: part_of GO:0021618 ! hypoglossal nerve morphogenesis

[Term]
id: GO:0021621
name: hypoglossal nerve structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the hypoglossal nerve. This process pertains to the physical shaping of a rudimentary structure. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN XII structural organization" RELATED []
synonym: "hypoglossal nerve structural organisation" EXACT [GOC:mah]
is_a: GO:0021604 ! cranial nerve structural organization
relationship: part_of GO:0021618 ! hypoglossal nerve morphogenesis

[Term]
id: GO:0021622
name: oculomotor nerve morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the oculomotor nerve is generated and organized. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN III morphogenesis" RELATED []
is_a: GO:0021602 ! cranial nerve morphogenesis
relationship: part_of GO:0021557 ! oculomotor nerve development

[Term]
id: GO:0021623
name: oculomotor nerve formation
namespace: biological_process
def: "The process that gives rise to the oculomotor nerve. This process pertains to the initial formation of a structure from unspecified parts. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN III biosynthesis" RELATED []
synonym: "CN III formation" RELATED []
is_a: GO:0021603 ! cranial nerve formation
relationship: part_of GO:0021622 ! oculomotor nerve morphogenesis

[Term]
id: GO:0021624
name: oculomotor nerve structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN III structural organization" RELATED []
synonym: "oculomotor nerve structural organisation" EXACT [GOC:mah]
is_a: GO:0021604 ! cranial nerve structural organization
relationship: part_of GO:0021622 ! oculomotor nerve morphogenesis

[Term]
id: GO:0021625
name: oculomotor nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the oculomotor nerve to attain its fully functional state. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN III maturation" RELATED []
is_a: GO:0021605 ! cranial nerve maturation
relationship: part_of GO:0021557 ! oculomotor nerve development

[Term]
id: GO:0021626
name: central nervous system maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the central nervous system to attain its fully functional state. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0582227089]
comment: This term was added by GO_REF:0000021.
is_a: GO:0071695 ! anatomical structure maturation
relationship: part_of GO:0007417 ! central nervous system development

[Term]
id: GO:0021627
name: olfactory nerve morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the olfactory nerve is generated and organized. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN I morphogenesis" RELATED []
is_a: GO:0021602 ! cranial nerve morphogenesis
relationship: part_of GO:0021553 ! olfactory nerve development

[Term]
id: GO:0021628
name: olfactory nerve formation
namespace: biological_process
def: "The process that gives rise to the olfactory nerve. This process pertains to the initial formation of a structure from unspecified parts. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN I biosynthesis" RELATED []
synonym: "CN I formation" RELATED []
is_a: GO:0021603 ! cranial nerve formation
relationship: part_of GO:0021627 ! olfactory nerve morphogenesis

[Term]
id: GO:0021629
name: olfactory nerve structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN I structural organization" RELATED []
synonym: "olfactory nerve structural organisation" EXACT [GOC:mah]
is_a: GO:0021604 ! cranial nerve structural organization
relationship: part_of GO:0021627 ! olfactory nerve morphogenesis

[Term]
id: GO:0021630
name: olfactory nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the olfactory nerve to attain its fully functional state. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "CN I maturation" EXACT []
is_a: GO:0021605 ! cranial nerve maturation
relationship: part_of GO:0021553 ! olfactory nerve development

[Term]
id: GO:0021631
name: optic nerve morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the optic nerve is generated and organized. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN II morphogenesis" RELATED []
is_a: GO:0021602 ! cranial nerve morphogenesis
relationship: part_of GO:0021554 ! optic nerve development

[Term]
id: GO:0021632
name: optic nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the optic nerve to attain its fully functional state. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN II maturation" EXACT []
is_a: GO:0021605 ! cranial nerve maturation
relationship: part_of GO:0021554 ! optic nerve development

[Term]
id: GO:0021633
name: optic nerve structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the optic nerve. This process pertains to the physical shaping of a rudimentary structure. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN II structural organization" RELATED []
synonym: "optic nerve structural organisation" EXACT [GOC:mah]
is_a: GO:0021604 ! cranial nerve structural organization
relationship: part_of GO:0021631 ! optic nerve morphogenesis

[Term]
id: GO:0021634
name: optic nerve formation
namespace: biological_process
def: "The process that gives rise to the optic nerve. This process pertains to the initial formation of a structure from unspecified parts. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN II biosynthesis" RELATED []
synonym: "CN II formation" RELATED []
is_a: GO:0021603 ! cranial nerve formation
relationship: part_of GO:0021631 ! optic nerve morphogenesis

[Term]
id: GO:0021635
name: trigeminal nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the trigeminal nerve to attain its fully functional state. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN V maturation" RELATED []
is_a: GO:0021605 ! cranial nerve maturation
relationship: part_of GO:0021559 ! trigeminal nerve development

[Term]
id: GO:0021636
name: trigeminal nerve morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the trigeminal nerve is generated and organized. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN V morphogenesis" RELATED []
is_a: GO:0021602 ! cranial nerve morphogenesis
relationship: part_of GO:0021559 ! trigeminal nerve development

[Term]
id: GO:0021637
name: trigeminal nerve structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN V structural organization" RELATED []
synonym: "trigeminal nerve structural organisation" EXACT [GOC:mah]
is_a: GO:0021604 ! cranial nerve structural organization
relationship: part_of GO:0021636 ! trigeminal nerve morphogenesis

[Term]
id: GO:0021638
name: trigeminal nerve formation
namespace: biological_process
def: "The process that gives rise to the trigeminal nerve. This process pertains to the initial formation of a structure from unspecified parts. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN V biosynthesis" RELATED []
synonym: "CN V formation" RELATED []
is_a: GO:0021603 ! cranial nerve formation
relationship: part_of GO:0021636 ! trigeminal nerve morphogenesis

[Term]
id: GO:0021639
name: trochlear nerve morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the trochlear nerve is generated and organized. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CH IV morphogenesis" RELATED []
is_a: GO:0021602 ! cranial nerve morphogenesis
relationship: part_of GO:0021558 ! trochlear nerve development

[Term]
id: GO:0021640
name: trochlear nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the trochlear nerve to attain its fully functional state. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN IV maturation" RELATED []
is_a: GO:0021605 ! cranial nerve maturation
relationship: part_of GO:0021558 ! trochlear nerve development

[Term]
id: GO:0021641
name: trochlear nerve structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the trochlear nerve. This process pertains to the physical shaping of a rudimentary structure. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN IV structural organization" RELATED []
synonym: "trochlear nerve structural organisation" EXACT [GOC:mah]
is_a: GO:0021604 ! cranial nerve structural organization
relationship: part_of GO:0021639 ! trochlear nerve morphogenesis

[Term]
id: GO:0021642
name: trochlear nerve formation
namespace: biological_process
def: "The process that gives rise to the trochlear nerve. This process pertains to the initial formation of a structure from unspecified parts. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN IV biosynthesis" RELATED []
synonym: "CN IV formation" RELATED []
is_a: GO:0021603 ! cranial nerve formation
relationship: part_of GO:0021639 ! trochlear nerve morphogenesis

[Term]
id: GO:0021643
name: vagus nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the vagus nerve to attain its fully functional state. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN X maturation" RELATED []
is_a: GO:0021605 ! cranial nerve maturation
relationship: part_of GO:0021564 ! vagus nerve development

[Term]
id: GO:0021644
name: vagus nerve morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the vagus nerve is generated and organized. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN X morphogenesis" RELATED []
is_a: GO:0021602 ! cranial nerve morphogenesis
relationship: part_of GO:0021564 ! vagus nerve development

[Term]
id: GO:0021645
name: vagus nerve structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the vagus nerve. This process pertains to the physical shaping of a rudimentary structure. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN X structural organization" RELATED []
synonym: "vagus nerve structural organisation" EXACT [GOC:mah]
is_a: GO:0021604 ! cranial nerve structural organization
relationship: part_of GO:0021644 ! vagus nerve morphogenesis

[Term]
id: GO:0021646
name: vagus nerve formation
namespace: biological_process
def: "The process that gives rise to the vagus nerve. This process pertains to the initial formation of a structure from unspecified parts. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN X biosynthesis" RELATED []
synonym: "CN X formation" RELATED []
is_a: GO:0021603 ! cranial nerve formation
relationship: part_of GO:0021644 ! vagus nerve morphogenesis

[Term]
id: GO:0021647
name: vestibulocochlear nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the vestibulocochlear nerve to attain its fully functional state. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "auditory nerve maturation" RELATED []
synonym: "CN VIII maturation" RELATED []
is_a: GO:0021605 ! cranial nerve maturation
relationship: part_of GO:0021562 ! vestibulocochlear nerve development

[Term]
id: GO:0021648
name: vestibulocochlear nerve morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the vestibulocochlear nerve is generated and organized. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN VIII morphogenesis" RELATED []
is_a: GO:0021602 ! cranial nerve morphogenesis
relationship: part_of GO:0021562 ! vestibulocochlear nerve development

[Term]
id: GO:0021649
name: vestibulocochlear nerve structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the vestibulocochlear nerve. This process pertains to the physical shaping of a rudimentary structure. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN VII structural organization" RELATED []
synonym: "vestibulocochlear nerve structural organisation" EXACT [GOC:mah]
is_a: GO:0021604 ! cranial nerve structural organization
relationship: part_of GO:0021648 ! vestibulocochlear nerve morphogenesis

[Term]
id: GO:0021650
name: vestibulocochlear nerve formation
namespace: biological_process
def: "The process that gives rise to the vestibulocochlear nerve. This process pertains to the initial formation of a structure from unspecified parts. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN VII formation" RELATED []
is_a: GO:0021603 ! cranial nerve formation
relationship: part_of GO:0021648 ! vestibulocochlear nerve morphogenesis

[Term]
id: GO:0021651
name: rhombomere 1 morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of rhombomere 1 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021593 ! rhombomere morphogenesis
relationship: part_of GO:0021567 ! rhombomere 1 development

[Term]
id: GO:0021652
name: rhombomere 1 formation
namespace: biological_process
def: "The process that gives rise to rhombomere 1. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021594 ! rhombomere formation
relationship: part_of GO:0021651 ! rhombomere 1 morphogenesis

[Term]
id: GO:0021653
name: rhombomere 1 structural organization
namespace: biological_process
def: "The process that contributes to creating the structural organization of rhombomere 1. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "rhombomere 1 structural organisation" EXACT [GOC:mah]
is_a: GO:0021595 ! rhombomere structural organization
relationship: part_of GO:0021651 ! rhombomere 1 morphogenesis

[Term]
id: GO:0021654
name: rhombomere boundary formation
namespace: biological_process
def: "The process that gives rise to a rhombomere boundary. This process pertains to the initial formation of a boundary delimiting a rhombomere. Rhombomeres are transverse segments of the developing rhombencephalon that are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048859 ! formation of anatomical boundary
relationship: part_of GO:0021594 ! rhombomere formation

[Term]
id: GO:0021655
name: rhombomere 2 morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of rhombomere 2 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021593 ! rhombomere morphogenesis
relationship: part_of GO:0021568 ! rhombomere 2 development

[Term]
id: GO:0021656
name: rhombomere 2 structural organization
namespace: biological_process
def: "The process that contributes to creating the structural organization of rhombomere 2. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "rhombomere 2 structural organisation" EXACT [GOC:mah]
is_a: GO:0021595 ! rhombomere structural organization
relationship: part_of GO:0021655 ! rhombomere 2 morphogenesis

[Term]
id: GO:0021657
name: rhombomere 2 formation
namespace: biological_process
def: "The process that gives rise to rhombomere 2. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021594 ! rhombomere formation
relationship: part_of GO:0021655 ! rhombomere 2 morphogenesis

[Term]
id: GO:0021658
name: rhombomere 3 morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of rhombomere 3 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021593 ! rhombomere morphogenesis
relationship: part_of GO:0021569 ! rhombomere 3 development

[Term]
id: GO:0021659
name: rhombomere 3 structural organization
namespace: biological_process
def: "The process that contributes to creating the structural organization of rhombomere 3. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "rhombomere 3 structural organisation" EXACT [GOC:mah]
is_a: GO:0021595 ! rhombomere structural organization
relationship: part_of GO:0021658 ! rhombomere 3 morphogenesis

[Term]
id: GO:0021660
name: rhombomere 3 formation
namespace: biological_process
def: "The process that gives rise to rhombomere 3. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021594 ! rhombomere formation
relationship: part_of GO:0021658 ! rhombomere 3 morphogenesis

[Term]
id: GO:0021661
name: rhombomere 4 morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of rhombomere 4 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021593 ! rhombomere morphogenesis
relationship: part_of GO:0021570 ! rhombomere 4 development

[Term]
id: GO:0021662
name: rhombomere 4 structural organization
namespace: biological_process
def: "The process that contributes to creating the structural organization of rhombomere 4. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "rhombomere 4 structural organisation" EXACT [GOC:mah]
is_a: GO:0021595 ! rhombomere structural organization
relationship: part_of GO:0021661 ! rhombomere 4 morphogenesis

[Term]
id: GO:0021663
name: rhombomere 4 formation
namespace: biological_process
def: "The process that gives rise to rhombomere 4. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021594 ! rhombomere formation
relationship: part_of GO:0021661 ! rhombomere 4 morphogenesis

[Term]
id: GO:0021664
name: rhombomere 5 morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of rhombomere 5 are generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021593 ! rhombomere morphogenesis
relationship: part_of GO:0021571 ! rhombomere 5 development

[Term]
id: GO:0021665
name: rhombomere 5 structural organization
namespace: biological_process
def: "The process that contributes to creating the structural organization of rhombomere 5. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "rhombomere 5 structural organisation" EXACT [GOC:mah]
is_a: GO:0021595 ! rhombomere structural organization
relationship: part_of GO:0021664 ! rhombomere 5 morphogenesis

[Term]
id: GO:0021666
name: rhombomere 5 formation
namespace: biological_process
def: "The process that gives rise to rhombomere 5. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021594 ! rhombomere formation
relationship: part_of GO:0021664 ! rhombomere 5 morphogenesis

[Term]
id: GO:0021667
name: rhombomere 6 morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of rhombomere 6 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021593 ! rhombomere morphogenesis
relationship: part_of GO:0021572 ! rhombomere 6 development

[Term]
id: GO:0021668
name: rhombomere 6 structural organization
namespace: biological_process
def: "The process that contributes to creating the structural organization of rhombomere 6. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "rhombomere 6 structural organisation" EXACT [GOC:mah]
is_a: GO:0021595 ! rhombomere structural organization
relationship: part_of GO:0021667 ! rhombomere 6 morphogenesis

[Term]
id: GO:0021669
name: rhombomere 6 formation
namespace: biological_process
def: "The process that gives rise to rhombomere 6. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021594 ! rhombomere formation
relationship: part_of GO:0021667 ! rhombomere 6 morphogenesis

[Term]
id: GO:0021670
name: lateral ventricle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the lateral ventricles over time, from the formation to the mature structure. The two lateral ventricles are a cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube. They are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0683400078]
comment: This term was added by GO_REF:0000021.
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021537 ! telencephalon development
relationship: part_of GO:0021591 ! ventricular system development

[Term]
id: GO:0021671
name: rhombomere 7 morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of rhombomere 7 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021593 ! rhombomere morphogenesis
relationship: part_of GO:0021573 ! rhombomere 7 development

[Term]
id: GO:0021672
name: rhombomere 7 structural organization
namespace: biological_process
def: "The process that contributes to creating the structural organization of rhombomere 7. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "rhombomere 7 structural organisation" EXACT [GOC:mah]
is_a: GO:0021595 ! rhombomere structural organization
relationship: part_of GO:0021671 ! rhombomere 7 morphogenesis

[Term]
id: GO:0021673
name: rhombomere 7 formation
namespace: biological_process
def: "The process that gives rise to rhombomere 7. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021594 ! rhombomere formation
relationship: part_of GO:0021671 ! rhombomere 7 morphogenesis

[Term]
id: GO:0021674
name: rhombomere 8 morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of rhombomere 8 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021593 ! rhombomere morphogenesis
relationship: part_of GO:0021574 ! rhombomere 8 development

[Term]
id: GO:0021675
name: nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of a nerve over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007399 ! nervous system development

[Term]
id: GO:0021676
name: rhombomere 8 structural organization
namespace: biological_process
def: "The process that contributes to creating the structural organization of rhombomere 8. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "rhombomere 8 structural organisation" EXACT [GOC:mah]
is_a: GO:0021595 ! rhombomere structural organization
relationship: part_of GO:0021674 ! rhombomere 8 morphogenesis

[Term]
id: GO:0021677
name: rhombomere 8 formation
namespace: biological_process
def: "The process that gives rise to rhombomere 8. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021594 ! rhombomere formation
relationship: part_of GO:0021674 ! rhombomere 8 morphogenesis

[Term]
id: GO:0021678
name: third ventricle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the third ventricle over time, from its formation to the mature structure. The third ventricle is the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami. Its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma, and it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0683400078]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021591 ! ventricular system development

[Term]
id: GO:0021679
name: cerebellar molecular layer development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cerebellar molecular layer nerve over time, from its formation to the mature structure. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021695 ! cerebellar cortex development

[Term]
id: GO:0021680
name: cerebellar Purkinje cell layer development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cerebellar Purkinje cell layer over time, from its formation to the mature structure. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021695 ! cerebellar cortex development

[Term]
id: GO:0021681
name: cerebellar granular layer development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cerebellar granule layer over time, from its formation to the mature structure. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021695 ! cerebellar cortex development

[Term]
id: GO:0021682
name: nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a nerve to attain its fully functional state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0071695 ! anatomical structure maturation
relationship: part_of GO:0021675 ! nerve development

[Term]
id: GO:0021683
name: cerebellar granular layer morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the cerebellar granular layer is generated and organized. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0021681 ! cerebellar granular layer development
relationship: part_of GO:0021696 ! cerebellar cortex morphogenesis

[Term]
id: GO:0021684
name: cerebellar granular layer formation
namespace: biological_process
def: "The process that gives rise to the cerebellar granule layer. This process pertains to the initial formation of a structure from unspecified parts. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021683 ! cerebellar granular layer morphogenesis
relationship: part_of GO:0021697 ! cerebellar cortex formation

[Term]
id: GO:0021685
name: cerebellar granular layer structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the cerebellar granule layer. This process pertains to the physical shaping of a rudimentary structure. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "cerebellar granular layer structural organisation" EXACT [GOC:mah]
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0021683 ! cerebellar granular layer morphogenesis
relationship: part_of GO:0021698 ! cerebellar cortex structural organization

[Term]
id: GO:0021686
name: cerebellar granular layer maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar granular layer to attain its fully functional state. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0071695 ! anatomical structure maturation
relationship: part_of GO:0021681 ! cerebellar granular layer development
relationship: part_of GO:0021699 ! cerebellar cortex maturation

[Term]
id: GO:0021687
name: cerebellar molecular layer morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the cerebellar molecular layer is generated and organized. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0021679 ! cerebellar molecular layer development
relationship: part_of GO:0021696 ! cerebellar cortex morphogenesis

[Term]
id: GO:0021688
name: cerebellar molecular layer formation
namespace: biological_process
def: "The process that gives rise to the cerebellar molecular layer. This process pertains to the initial formation of a structure from unspecified parts. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021687 ! cerebellar molecular layer morphogenesis
relationship: part_of GO:0021697 ! cerebellar cortex formation

[Term]
id: GO:0021689
name: cerebellar molecular layer structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the cerebellar molecular layer. This process pertains to the physical shaping of a rudimentary structure. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "cerebellar molecular layer structural organisation" EXACT [GOC:mah]
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0021687 ! cerebellar molecular layer morphogenesis
relationship: part_of GO:0021698 ! cerebellar cortex structural organization

[Term]
id: GO:0021690
name: cerebellar molecular layer maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar molecular layer to attain its fully functional state. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0071695 ! anatomical structure maturation
relationship: part_of GO:0021679 ! cerebellar molecular layer development
relationship: part_of GO:0021699 ! cerebellar cortex maturation

[Term]
id: GO:0021691
name: cerebellar Purkinje cell layer maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar Purkinje cell layer to attain its fully functional state. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0071695 ! anatomical structure maturation
relationship: part_of GO:0021680 ! cerebellar Purkinje cell layer development
relationship: part_of GO:0021699 ! cerebellar cortex maturation

[Term]
id: GO:0021692
name: cerebellar Purkinje cell layer morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the cerebellar Purkinje cell layer is generated and organized. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0021680 ! cerebellar Purkinje cell layer development
relationship: part_of GO:0021696 ! cerebellar cortex morphogenesis

[Term]
id: GO:0021693
name: cerebellar Purkinje cell layer structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the cerebellar Purkinje cell layer. This process pertains to the physical shaping of a rudimentary structure. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "cerebellar Purkinje cell layer structural organisation" EXACT [GOC:mah]
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0021692 ! cerebellar Purkinje cell layer morphogenesis
relationship: part_of GO:0021698 ! cerebellar cortex structural organization

[Term]
id: GO:0021694
name: cerebellar Purkinje cell layer formation
namespace: biological_process
def: "The process that gives rise to the cerebellar Purkinje cell layer. This process pertains to the initial formation of a structure from unspecified parts. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021692 ! cerebellar Purkinje cell layer morphogenesis
relationship: part_of GO:0021697 ! cerebellar cortex formation

[Term]
id: GO:0021695
name: cerebellar cortex development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cerebellar cortex over time, from its formation to the mature structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021549 ! cerebellum development

[Term]
id: GO:0021696
name: cerebellar cortex morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the cranial nerves are generated and organized. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0021587 ! cerebellum morphogenesis
relationship: part_of GO:0021695 ! cerebellar cortex development

[Term]
id: GO:0021697
name: cerebellar cortex formation
namespace: biological_process
def: "The process that gives rise to the cerebellar cortex. This process pertains to the initial formation of a structure from unspecified parts. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021696 ! cerebellar cortex morphogenesis

[Term]
id: GO:0021698
name: cerebellar cortex structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the cerebellar cortex. This process pertains to the physical shaping of a rudimentary structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "cerebellar cortex structural organisation" EXACT [GOC:mah]
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0021696 ! cerebellar cortex morphogenesis

[Term]
id: GO:0021699
name: cerebellar cortex maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar cortex to attain its fully functional state. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0071695 ! anatomical structure maturation
relationship: part_of GO:0021590 ! cerebellum maturation
relationship: part_of GO:0021695 ! cerebellar cortex development

[Term]
id: GO:0021700
name: developmental maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
subset: goslim_chembl
subset: goslim_generic
is_a: GO:0044767 ! single-organism developmental process

[Term]
id: GO:0021701
name: cerebellar Golgi cell differentiation
namespace: biological_process
def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Golgi cell. Differentiation includes the processes involved in commitment of a neuroblast to a Golgi cell fate. A cerebellar Golgi cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021533 ! cell differentiation in hindbrain
is_a: GO:0021953 ! central nervous system neuron differentiation
is_a: GO:0097154 ! GABAergic neuron differentiation
relationship: part_of GO:0021684 ! cerebellar granular layer formation

[Term]
id: GO:0021702
name: cerebellar Purkinje cell differentiation
namespace: biological_process
def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Purkinje cell. Differentiation includes the processes involved in commitment of a neuroblast to a Purkinje cell fate. A Purkinje cell is an inhibitory GABAergic neuron found in the cerebellar cortex that projects to the deep cerebellar nuclei and brain stem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021533 ! cell differentiation in hindbrain
is_a: GO:0021953 ! central nervous system neuron differentiation
relationship: part_of GO:0021694 ! cerebellar Purkinje cell layer formation

[Term]
id: GO:0021703
name: locus ceruleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the locus ceruleus over time, from its formation to the mature structure. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "locus caeruleus development" EXACT []
synonym: "locus coeruleus development" EXACT []
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021548 ! pons development

[Term]
id: GO:0021704
name: locus ceruleus morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the locus ceruleus is generated and organized. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0021583 ! pons morphogenesis
relationship: part_of GO:0021703 ! locus ceruleus development

[Term]
id: GO:0021705
name: locus ceruleus formation
namespace: biological_process
def: "The process that gives rise to the locus ceruleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021584 ! pons formation
relationship: part_of GO:0021704 ! locus ceruleus morphogenesis

[Term]
id: GO:0021706
name: locus ceruleus maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the locus ceruleus to attain its fully functional state. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0071695 ! anatomical structure maturation
relationship: part_of GO:0021586 ! pons maturation
relationship: part_of GO:0021703 ! locus ceruleus development

[Term]
id: GO:0021707
name: cerebellar granule cell differentiation
namespace: biological_process
def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar granule cell. Differentiation includes the processes involved in commitment of a neuroblast to a granule cell fate. A granule cell is a glutamatergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021533 ! cell differentiation in hindbrain
is_a: GO:0021953 ! central nervous system neuron differentiation
relationship: part_of GO:0021684 ! cerebellar granular layer formation

[Term]
id: GO:0021708
name: Lugaro cell differentiation
namespace: biological_process
def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature Lugaro cell. Differentiation includes the processes involved in commitment of a neuroblast to a Lugaro cell fate. A Lugaro cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021533 ! cell differentiation in hindbrain
is_a: GO:0021953 ! central nervous system neuron differentiation
is_a: GO:0097154 ! GABAergic neuron differentiation
relationship: part_of GO:0021697 ! cerebellar cortex formation

[Term]
id: GO:0021709
name: cerebellar basket cell differentiation
namespace: biological_process
def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar basket cell. Differentiation includes the processes involved in commitment of a neuroblast to a cerebellar basket cell fate. A cerebellar basket cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021533 ! cell differentiation in hindbrain
is_a: GO:0021953 ! central nervous system neuron differentiation
relationship: part_of GO:0021688 ! cerebellar molecular layer formation

[Term]
id: GO:0021710
name: cerebellar stellate cell differentiation
namespace: biological_process
def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar stellate cell. Differentiation includes the processes involved in commitment of a neuroblast to a cerebellar stellate cell fate. A cerebellar stellate cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021533 ! cell differentiation in hindbrain
is_a: GO:0021953 ! central nervous system neuron differentiation
relationship: part_of GO:0021688 ! cerebellar molecular layer formation

[Term]
id: GO:0021711
name: cerebellar unipolar brush cell differentiation
namespace: biological_process
def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature unipolar brush cell in the cerebellum. Differentiation includes the processes involved in commitment of a neuroblast to a unipolar brush cell fate. A unipolar brush cell is a glutamatergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021533 ! cell differentiation in hindbrain
is_a: GO:0021953 ! central nervous system neuron differentiation
relationship: part_of GO:0021684 ! cerebellar granular layer formation

[Term]
id: GO:0021712
name: candelabrum cell differentiation
namespace: biological_process
def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature candelabrum cell. Differentiation includes the processes involved in commitment of a neuroblast to a candelabrum cell fate. A candelabrum cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021533 ! cell differentiation in hindbrain
is_a: GO:0021953 ! central nervous system neuron differentiation
relationship: part_of GO:0021694 ! cerebellar Purkinje cell layer formation

[Term]
id: GO:0021713
name: inferior olivary nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the inferior olivary nucleus over time, from its formation to the mature structure. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "inferior olive development" RELATED []
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021550 ! medulla oblongata development

[Term]
id: GO:0021714
name: inferior olivary nucleus morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the inferior olivary nucleus is generated and organized. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "inferior olive morphogenesis" RELATED []
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0021579 ! medulla oblongata morphogenesis
relationship: part_of GO:0021713 ! inferior olivary nucleus development

[Term]
id: GO:0021715
name: inferior olivary nucleus formation
namespace: biological_process
def: "The process that gives rise to the inferior olivary nucleus. This process pertains to the initial formation of a structure from unspecified parts. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "inferior olive biosynthesis" RELATED []
synonym: "inferior olive formation" RELATED []
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021580 ! medulla oblongata formation
relationship: part_of GO:0021714 ! inferior olivary nucleus morphogenesis

[Term]
id: GO:0021716
name: inferior olivary nucleus structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the inferior olivary nucleus structure. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "inferior olivary nucleus structural organisation" EXACT [GOC:mah]
synonym: "inferior olive structural organization" RELATED []
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0021581 ! medulla oblongata structural organization
relationship: part_of GO:0021714 ! inferior olivary nucleus morphogenesis

[Term]
id: GO:0021717
name: inferior olivary nucleus maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the inferior olivary nucleus to attain its fully functional state. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "inferior olive maturation" RELATED []
is_a: GO:0071695 ! anatomical structure maturation
relationship: part_of GO:0021582 ! medulla oblongata maturation
relationship: part_of GO:0021713 ! inferior olivary nucleus development

[Term]
id: GO:0021718
name: superior olivary nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the superior olivary nucleus over time, from its formation to the mature structure. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "superior olive development" RELATED []
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021548 ! pons development

[Term]
id: GO:0021719
name: superior olivary nucleus morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the superior olivary nucleus is generated and organized. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "superior olive morphogenesis" RELATED []
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0021583 ! pons morphogenesis
relationship: part_of GO:0021718 ! superior olivary nucleus development

[Term]
id: GO:0021720
name: superior olivary nucleus formation
namespace: biological_process
def: "The process that gives rise to the superior olivary nucleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021584 ! pons formation
relationship: part_of GO:0021719 ! superior olivary nucleus morphogenesis

[Term]
id: GO:0021721
name: superior olivary nucleus structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the superior olivary nucleus structure. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "superior olivary nucleus structural organisation" EXACT [GOC:mah]
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0021585 ! pons structural organization
relationship: part_of GO:0021719 ! superior olivary nucleus morphogenesis

[Term]
id: GO:0021722
name: superior olivary nucleus maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the superior olivary nucleus to attain its fully functional state. The superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "superior olive maturation" RELATED []
is_a: GO:0071695 ! anatomical structure maturation
relationship: part_of GO:0021586 ! pons maturation
relationship: part_of GO:0021718 ! superior olivary nucleus development

[Term]
id: GO:0021723
name: medullary reticular formation development
namespace: biological_process
def: "The process whose specific outcome is the progression of the medullary reticular formation over time, from its formation to the mature structure. The medullary reticular formation is a series of brain nuclei located in the medulla oblongata." [GO_REF:0000021, GOC:cjm, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, http://en.wikipedia.org/wiki/Rhombencephalon, http://www.brainspan.org]
comment: This term was added by GO_REF:0000021.
synonym: "rhombencephalic reticular formation development" BROAD []
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021550 ! medulla oblongata development

[Term]
id: GO:0021724
name: inferior raphe nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the inferior raphe nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cjm, GOC:cls, GOC:curators, GOC:cvs, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:19003874, ZFA:0000366]
comment: This term was added by GO_REF:0000021.
synonym: "inferior central nucleus development" BROAD []
synonym: "posterior raphe nucleus development" BROAD []
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021723 ! medullary reticular formation development

[Term]
id: GO:0021725
name: superior raphe nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the superior raphe nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cjm, GOC:cls, GOC:curators, GOC:cvs, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:19003874, ZFA:0000440]
comment: This term was added by GO_REF:0000021.
synonym: "anterior raphe nucleus development" BROAD []
synonym: "superior central nucleus development" BROAD []
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021723 ! medullary reticular formation development

[Term]
id: GO:0021726
name: lateral reticular nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the lateral reticular nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021723 ! medullary reticular formation development

[Term]
id: GO:0021727
name: intermediate reticular formation development
namespace: biological_process
def: "The process whose specific outcome is the progression of the intermediate reticular formation over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "intermediate reticular nucleus development" EXACT [http://www.brainspan.org]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021723 ! medullary reticular formation development

[Term]
id: GO:0021728
name: inferior reticular formation development
namespace: biological_process
def: "The process whose specific outcome is the progression of the inferior reticular formation over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021723 ! medullary reticular formation development

[Term]
id: GO:0021729
name: superior reticular formation development
namespace: biological_process
def: "The process whose specific outcome is the progression of the superior reticular formation over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021723 ! medullary reticular formation development

[Term]
id: GO:0021730
name: trigeminal sensory nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the trigeminal sensory nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021. Note that this term was placed as a child of 'brain development' because the nucleus spans multiple brain regions from midbrain to spinal cord.
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0007420 ! brain development

[Term]
id: GO:0021731
name: trigeminal motor nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the trigeminal motor nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021548 ! pons development

[Term]
id: GO:0021732
name: midbrain-hindbrain boundary maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15541513]
comment: This term was added by GO_REF:0000021.
synonym: "isthmus maturation" RELATED []
synonym: "MHB maturation" RELATED []
is_a: GO:0071695 ! anatomical structure maturation
relationship: part_of GO:0030917 ! midbrain-hindbrain boundary development

[Term]
id: GO:0021735
name: dentate nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the dentate nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021549 ! cerebellum development

[Term]
id: GO:0021736
name: globose nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the globose nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021549 ! cerebellum development

[Term]
id: GO:0021737
name: emboliform nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the emboliform nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021549 ! cerebellum development

[Term]
id: GO:0021738
name: fastigial nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the fastigial nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021549 ! cerebellum development

[Term]
id: GO:0021739
name: mesencephalic trigeminal nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the mesencephalic trigeminal nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021730 ! trigeminal sensory nucleus development

[Term]
id: GO:0021740
name: principal sensory nucleus of trigeminal nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pontine nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021. Note that this term was placed as a child of 'brain development' because the nucleus spans multiple brain regions.
synonym: "pontine nucleus development" BROAD [GOC:dph]
is_a: GO:0021730 ! trigeminal sensory nucleus development

[Term]
id: GO:0021741
name: spinal trigeminal nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the spinal trigeminal nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021730 ! trigeminal sensory nucleus development

[Term]
id: GO:0021742
name: abducens nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the abducens nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021548 ! pons development

[Term]
id: GO:0021743
name: hypoglossal nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the hypoglossal nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021550 ! medulla oblongata development

[Term]
id: GO:0021744
name: dorsal motor nucleus of vagus nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of the dorsal motor nucleus of the vagus nerve over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021550 ! medulla oblongata development

[Term]
id: GO:0021745
name: nucleus ambiguus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the nucleus ambiguus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021550 ! medulla oblongata development

[Term]
id: GO:0021746
name: solitary nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the solitary nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021550 ! medulla oblongata development

[Term]
id: GO:0021747
name: cochlear nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cochlear nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021548 ! pons development

[Term]
id: GO:0021748
name: dorsal cochlear nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the dorsal cochlear nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021747 ! cochlear nucleus development

[Term]
id: GO:0021749
name: ventral cochlear nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the ventral cochlear nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021747 ! cochlear nucleus development

[Term]
id: GO:0021750
name: vestibular nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the vestibular nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16221589]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021548 ! pons development
relationship: part_of GO:0021550 ! medulla oblongata development

[Term]
id: GO:0021751
name: salivary nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of a salivary nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021548 ! pons development

[Term]
id: GO:0021752
name: inferior salivary nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the inferior salivary nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021751 ! salivary nucleus development

[Term]
id: GO:0021753
name: superior salivary nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the superior salivary nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021751 ! salivary nucleus development

[Term]
id: GO:0021754
name: facial nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the facial nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021548 ! pons development

[Term]
id: GO:0021755
name: eurydendroid cell differentiation
namespace: biological_process
def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature eurydendroid cell. Differentiation includes the processes involved in commitment of a neuroblast to a eurydendroid cell fate. A eurydendroid cell is an efferent neuron found in the cerebellar cortex of teleosts." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15892096]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021533 ! cell differentiation in hindbrain
is_a: GO:0021953 ! central nervous system neuron differentiation
relationship: part_of GO:0021697 ! cerebellar cortex formation

[Term]
id: GO:0021756
name: striatum development
namespace: biological_process
def: "The progression of the striatum over time from its initial formation until its mature state. The striatum is a region of the forebrain consisting of the caudate nucleus, putamen and fundus striati." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420]
comment: This term was added by GO_REF:0000021.
synonym: "neostriatum development" EXACT []
synonym: "striate nucleus development" EXACT []
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021544 ! subpallium development

[Term]
id: GO:0021757
name: caudate nucleus development
namespace: biological_process
def: "The progression of the caudate nucleus over time from its initial formation until its mature state. The caudate nucleus is the C-shaped structures of the striatum containing input neurons involved with control of voluntary movement in the brain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021756 ! striatum development

[Term]
id: GO:0021758
name: putamen development
namespace: biological_process
def: "The progression of the putamen over time from its initial formation until its mature state. The putamen is the lens-shaped basal ganglion involved with control of voluntary movement in the brain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021756 ! striatum development

[Term]
id: GO:0021759
name: globus pallidus development
namespace: biological_process
def: "The progression of the globus pallidus over time from its initial formation until its mature state. The globus pallidus is one of the basal ganglia involved with control of voluntary movement in the brain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420]
comment: This term was added by GO_REF:0000021.
synonym: "pallidum development" EXACT [PMID:16271465]
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021536 ! diencephalon development

[Term]
id: GO:0021761
name: limbic system development
namespace: biological_process
def: "The progression of the limbic system over time from its initial formation until its mature state. The limbic system is a collection of structures in the brain involved in emotion, motivation and emotional aspects of memory." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048731 ! system development
relationship: part_of GO:0030900 ! forebrain development

[Term]
id: GO:0021762
name: substantia nigra development
namespace: biological_process
def: "The progression of the substantia nigra over time from its initial formation until its mature state. The substantia nigra is the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis)." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343, ISBN:0878937420]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0030901 ! midbrain development

[Term]
id: GO:0021763
name: subthalamic nucleus development
namespace: biological_process
def: "The progression of the subthalamic nucleus over time from its initial formation until its mature state. The subthalamic nucleus is the lens-shaped nucleus located in the ventral part of the subthalamus on the inner aspect of the internal capsule that is concerned with the integration of somatic motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420]
comment: This term was added by GO_REF:0000021.
synonym: "corpus luysi development" RELATED []
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021539 ! subthalamus development

[Term]
id: GO:0021764
name: amygdala development
namespace: biological_process
def: "The progression of the amygdala over time from its initial formation until its mature state. The amygdala is an almond-shaped set of neurons in the medial temporal lobe of the brain that play a key role in processing emotions such as fear and pleasure." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420]
comment: This term was added by GO_REF:0000021.
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021761 ! limbic system development

[Term]
id: GO:0021765
name: cingulate gyrus development
namespace: biological_process
def: "The progression of the cingulate gyrus over time from its initial formation until its mature state. The cingulate gyrus is a ridge in the cerebral cortex located dorsal to the corpus callosum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420]
comment: This term was added by GO_REF:0000021.
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021761 ! limbic system development

[Term]
id: GO:0021766
name: hippocampus development
namespace: biological_process
def: "The progression of the hippocampus over time from its initial formation until its mature state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420, UBERON:0002421]
comment: This term was added by GO_REF:0000021.
synonym: "hippocampal formation development" EXACT [ABA:HPF]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021543 ! pallium development
relationship: part_of GO:0021761 ! limbic system development

[Term]
id: GO:0021767
name: mammillary body development
namespace: biological_process
def: "The progression of the mammillary body over time from its initial formation until its mature state. The mammillary body is a protrusion at the posterior end of the hypothalamus that contains hypothalamic nuclei." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420]
comment: This term was added by GO_REF:0000021.
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021536 ! diencephalon development
relationship: part_of GO:0021761 ! limbic system development

[Term]
id: GO:0021768
name: nucleus accumbens development
namespace: biological_process
def: "The progression of the nucleus accumbens over time from its initial formation until its mature state. The nucleus accumbens is a collection of pleomorphic cells in the caudal part of the anterior horn of the lateral ventricle, in the region of the olfactory tubercle, lying between the head of the caudate nucleus and the anterior perforated substance. It is part of the ventral striatum, a composite structure considered part of the basal ganglia." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420]
comment: This term was added by GO_REF:0000021.
synonym: "accumbens nucleus development" EXACT [GOC:dgh]
synonym: "ventral striatum development" BROAD []
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021756 ! striatum development
relationship: part_of GO:0021761 ! limbic system development

[Term]
id: GO:0021769
name: orbitofrontal cortex development
namespace: biological_process
def: "The progression of the orbitofrontal cortex over time from its initial formation until its mature state. The orbitofrontal cortex is a cerebral cortex region located in the frontal lobe." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420]
comment: This term was added by GO_REF:0000021.
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021761 ! limbic system development

[Term]
id: GO:0021770
name: parahippocampal gyrus development
namespace: biological_process
def: "The progression of the parahippocampal gyrus over time from its initial formation until its mature state. The parahippocampal gyrus is a ridge in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420]
comment: This term was added by GO_REF:0000021.
synonym: "hippocampal gyrus development" EXACT [GOC:dgh]
xref: Wikipedia:parahippocampal_gyrus
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021761 ! limbic system development

[Term]
id: GO:0021771
name: lateral geniculate nucleus development
namespace: biological_process
def: "The progression of the lateral geniculate nucleus over time from its initial formation until its mature state. The lateral geniculate nucleus is the primary processor of visual information received from the retina." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420]
comment: This term was added by GO_REF:0000021.
synonym: "LGN development" EXACT [GOC:dgh]
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021794 ! thalamus development

[Term]
id: GO:0021772
name: olfactory bulb development
namespace: biological_process
def: "The progression of the olfactory bulb over time from its initial formation until its mature state. The olfactory bulb coordinates neuronal signaling involved in the perception of smell. It receives input from the sensory neurons and outputs to the olfactory cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420]
comment: This term was added by GO_REF:0000021.
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021988 ! olfactory lobe development

[Term]
id: GO:0021773
name: striatal medium spiny neuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a medium spiny neuron residing in the striatum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420]
comment: This term was added by GO_REF:0000021.
synonym: "medium-sized spiny neuron differentiation" EXACT [PMID:25804741]
synonym: "striatal MSN differentiation" EXACT [PMID:25804741]
is_a: GO:0021879 ! forebrain neuron differentiation
relationship: part_of GO:0021756 ! striatum development

[Term]
id: GO:0021774
name: retinoic acid receptor signaling pathway involved in ventral spinal cord interneuron specification
namespace: biological_process
def: "The series of molecular signals initiated by binding of a ligand to a retinoic acid receptor in a precursor cell in the ventral spinal cord that contributes to the commitment of the precursor cell to an interneuron fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:sdb_2009, GOC:tb, PMID:11262869]
comment: This term was added by GO_REF:0000021.
synonym: "retinoic acid receptor signalling pathway involved in ventral spinal cord interneuron specification" EXACT []
is_a: GO:0060895 ! retinoic acid receptor signaling pathway involved in spinal cord dorsal/ventral patterning
intersection_of: GO:0048384 ! retinoic acid receptor signaling pathway
intersection_of: part_of GO:0021521 ! ventral spinal cord interneuron specification
relationship: part_of GO:0021521 ! ventral spinal cord interneuron specification

[Term]
id: GO:0021775
name: smoothened signaling pathway involved in ventral spinal cord interneuron specification
namespace: biological_process
def: "The series of molecular signals initiated by binding of a ligand to the transmembrane receptor smoothened in a precursor cell in the ventral spinal cord that contributes to the commitment of the precursor cell to an interneuron fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869]
comment: This term was added by GO_REF:0000021.
synonym: "hedgehog signaling pathway involved in ventral spinal cord interneuron specification" EXACT [GOC:bf, GOC:ecd]
synonym: "hh signaling pathway involved in ventral spinal cord interneuron specification" EXACT [GOC:bf, GOC:ecd]
synonym: "smoothened signalling pathway involved in ventral spinal cord interneuron specification" EXACT []
is_a: GO:0021910 ! smoothened signaling pathway involved in ventral spinal cord patterning
intersection_of: GO:0007224 ! smoothened signaling pathway
intersection_of: part_of GO:0021521 ! ventral spinal cord interneuron specification
relationship: part_of GO:0021521 ! ventral spinal cord interneuron specification

[Term]
id: GO:0021776
name: smoothened signaling pathway involved in spinal cord motor neuron cell fate specification
namespace: biological_process
def: "The series of molecular signals initiated by binding of a ligand to the transmembrane receptor smoothened in a precursor cell in the spinal cord that contributes to the process of a precursor cell becoming capable of differentiating autonomously into a motor neuron in an environment that is neutral with respect to the developmental pathway." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15936325]
comment: This term was added by GO_REF:0000021.
synonym: "hedgehog signaling pathway involved in spinal cord motor neuron cell fate specification" EXACT [GOC:bf, GOC:ecd]
synonym: "hh signaling pathway involved in spinal cord motor neuron cell fate specification" EXACT [GOC:bf, GOC:ecd]
synonym: "smoothened signalling pathway involved in spinal cord motor neuron cell fate specification" EXACT []
is_a: GO:0021910 ! smoothened signaling pathway involved in ventral spinal cord patterning
intersection_of: GO:0007224 ! smoothened signaling pathway
intersection_of: part_of GO:0021520 ! spinal cord motor neuron cell fate specification
relationship: part_of GO:0021520 ! spinal cord motor neuron cell fate specification

[Term]
id: GO:0021777
name: BMP signaling pathway involved in spinal cord association neuron specification
namespace: biological_process
def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to its commitment to an association neuron fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12593981]
comment: This term was added by GO_REF:0000021.
synonym: "BMP signalling pathway involved in spinal cord association neuron specification" EXACT []
synonym: "bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification" EXACT []
synonym: "bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification" EXACT []
is_a: GO:0021919 ! BMP signaling pathway involved in spinal cord dorsal/ventral patterning
is_a: GO:0021920 ! regulation of transcription from RNA polymerase II promoter involved in spinal cord association neuron specification
intersection_of: GO:0030509 ! BMP signaling pathway
intersection_of: part_of GO:0021519 ! spinal cord association neuron specification
relationship: part_of GO:0021519 ! spinal cord association neuron specification

[Term]
id: GO:0021778
name: oligodendrocyte cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into an oligodendrocyte in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021780 ! glial cell fate specification
relationship: part_of GO:0021779 ! oligodendrocyte cell fate commitment

[Term]
id: GO:0021779
name: oligodendrocyte cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into an oligodendrocyte." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021781 ! glial cell fate commitment
is_a: GO:0048709 ! oligodendrocyte differentiation

[Term]
id: GO:0021780
name: glial cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a glial cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0021781 ! glial cell fate commitment

[Term]
id: GO:0021781
name: glial cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a glial cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0010001 ! glial cell differentiation

[Term]
id: GO:0021782
name: glial cell development
namespace: biological_process
def: "The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048468 ! cell development
relationship: part_of GO:0010001 ! glial cell differentiation

[Term]
id: GO:0021783
name: preganglionic parasympathetic fiber development
namespace: biological_process
def: "The process whose specific outcome is the progression of a preganglionic parasympathetic fiber over time, from its formation to the mature structure. A preganglionic parasympathetic fiber is a cholinergic axonal fiber projecting from the CNS to a parasympathetic ganglion." [GO_REF:0000021, GOC:cjm, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048731 ! system development
relationship: part_of GO:0007417 ! central nervous system development
relationship: part_of GO:0048486 ! parasympathetic nervous system development

[Term]
id: GO:0021784
name: postganglionic parasympathetic fiber development
namespace: biological_process
def: "The process whose specific outcome is the progression of the postganglionic portion of the parasympathetic fiber over time, from its formation to the mature structure. The parasympathetic fiber is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048483 ! autonomic nervous system development
relationship: part_of GO:0007422 ! peripheral nervous system development
relationship: part_of GO:0048486 ! parasympathetic nervous system development

[Term]
id: GO:0021785
name: branchiomotor neuron axon guidance
namespace: biological_process
def: "The process in which a branchiomotor neuron growth cone is directed to a specific target site. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:14699587]
comment: This term was added by GO_REF:0000021.
synonym: "BMN axon guidance" EXACT [PMID:14699587]
synonym: "branchial motor axon guidance" EXACT [PMID:14699587]
synonym: "special visceral motor neuron axon guidance" EXACT [PMID:14699587]
is_a: GO:0008045 ! motor neuron axon guidance

[Term]
id: GO:0021786
name: branchiomotor neuron axon guidance in neural tube
namespace: biological_process
def: "The process in which a branchiomotor neuron growth cone in the neural tube is directed to a specific target site in the neural tube. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:14699587]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021785 ! branchiomotor neuron axon guidance

[Term]
id: GO:0021787
name: chemorepulsion of branchiomotor neuron axon in neural tube
namespace: biological_process
def: "The process in which a branchiomotor neuron growth cone in the neural tube is directed to a specific target site in the neural tube in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:14699587]
comment: This term was added by GO_REF:0000021.
synonym: "negative chemotaxis of branchiomotor neuron axon in neural tube" EXACT [GOC:mah]
is_a: GO:0021786 ! branchiomotor neuron axon guidance in neural tube
is_a: GO:0021793 ! chemorepulsion of branchiomotor axon

[Term]
id: GO:0021788
name: chemoattraction of branchiomotor neuron axon in neural tube
namespace: biological_process
def: "The process in which a branchiomotor neuron growth cone in the neural tube is directed to a specific target site in the neural tube in response to an attractive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:14699587]
comment: This term was added by GO_REF:0000021.
synonym: "positive chemotaxis of branchiomotor neuron axon in neural tube" EXACT [GOC:mah]
is_a: GO:0021786 ! branchiomotor neuron axon guidance in neural tube
is_a: GO:0021792 ! chemoattraction of branchiomotor axon

[Term]
id: GO:0021789
name: branchiomotor neuron axon guidance in branchial arch mesenchyme
namespace: biological_process
def: "The process in which a branchiomotor neuron growth cone in the branchial arch mesenchyme is directed to a specific target site in the branchial arch mesenchyme. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:14699587]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021785 ! branchiomotor neuron axon guidance

[Term]
id: GO:0021790
name: chemorepulsion of branchiomotor neuron axon in branchial arch mesenchyme
namespace: biological_process
def: "The process in which a branchiomotor neuron growth cone in the branchial arch mesenchyme is directed to a specific target site in the branchial arch mesenchyme in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:14699587]
comment: This term was added by GO_REF:0000021.
synonym: "negative chemotaxis of branchiomotor neuron axon in branchial arch mesenchyme" EXACT [GOC:mah]
is_a: GO:0021789 ! branchiomotor neuron axon guidance in branchial arch mesenchyme
is_a: GO:0021793 ! chemorepulsion of branchiomotor axon

[Term]
id: GO:0021791
name: chemoattraction of branchiomotor neuron axon in branchial arch mesenchyme
namespace: biological_process
def: "The process in which a branchiomotor neuron growth cone in the branchial arch mesenchyme is directed to a specific target site in the branchial arch mesenchyme in response to an attractive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:14699587]
comment: This term was added by GO_REF:0000021.
synonym: "positive chemotaxis of branchiomotor neuron axon in branchial arch mesenchyme" EXACT [GOC:mah]
is_a: GO:0021789 ! branchiomotor neuron axon guidance in branchial arch mesenchyme
is_a: GO:0021792 ! chemoattraction of branchiomotor axon

[Term]
id: GO:0021792
name: chemoattraction of branchiomotor axon
namespace: biological_process
def: "The process in which a branchiomotor neuron growth cone is directed to a specific target site in response to an attractive chemical signal. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:14699587]
comment: This term was added by GO_REF:0000021.
synonym: "positive chemotaxis of branchiomotor axon" EXACT [GOC:mah]
is_a: GO:0061642 ! chemoattraction of axon
intersection_of: GO:0050918 ! positive chemotaxis
intersection_of: part_of GO:0021785 ! branchiomotor neuron axon guidance
relationship: part_of GO:0021785 ! branchiomotor neuron axon guidance

[Term]
id: GO:0021793
name: chemorepulsion of branchiomotor axon
namespace: biological_process
def: "The process in which a branchiomotor neuron growth cone is directed to a specific target site in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:14699587]
comment: This term was added by GO_REF:0000021.
synonym: "negative chemotaxis of branchiomotor axon" EXACT [GOC:mah]
is_a: GO:0061643 ! chemorepulsion of axon
intersection_of: GO:0050919 ! negative chemotaxis
intersection_of: part_of GO:0021785 ! branchiomotor neuron axon guidance
relationship: part_of GO:0021785 ! branchiomotor neuron axon guidance

[Term]
id: GO:0021794
name: thalamus development
namespace: biological_process
def: "The process in which the thalamus changes over time, from its initial formation to its mature state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021536 ! diencephalon development

[Term]
id: GO:0021795
name: cerebral cortex cell migration
namespace: biological_process
def: "The orderly movement of cells from one site to another in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0022029 ! telencephalon cell migration
relationship: part_of GO:0021987 ! cerebral cortex development

[Term]
id: GO:0021796
name: cerebral cortex regionalization
namespace: biological_process
def: "The regionalization process that results in the creation of areas within the cerebral cortex that will direct the behavior of cell migration and differentiation as the cortex develops." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "cerebral cortex arealization" EXACT []
synonym: "cerebral cortex pattern biosynthesis" EXACT []
synonym: "cerebral cortex pattern formation" EXACT []
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0021978 ! telencephalon regionalization
relationship: part_of GO:0021987 ! cerebral cortex development

[Term]
id: GO:0021797
name: forebrain anterior/posterior pattern specification
namespace: biological_process
def: "The creation of specific areas of progenitor domains along the anterior-posterior axis of the developing forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "forebrain anterior-posterior pattern specification" EXACT []
is_a: GO:0009952 ! anterior/posterior pattern specification
relationship: part_of GO:0021871 ! forebrain regionalization

[Term]
id: GO:0021798
name: forebrain dorsal/ventral pattern formation
namespace: biological_process
def: "The formation of specific regional progenitor domains along the dorsal-ventral axis in the developing forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "forebrain dorsal-ventral pattern formation" EXACT [GOC:mah]
synonym: "forebrain dorsoventral pattern formation" EXACT [GOC:mah]
is_a: GO:0009953 ! dorsal/ventral pattern formation
relationship: part_of GO:0021871 ! forebrain regionalization

[Term]
id: GO:0021799
name: cerebral cortex radially oriented cell migration
namespace: biological_process
def: "The migration of cells in the developing cerebral cortex in which cells move from the ventricular and/or subventricular zone toward the surface of the brain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021795 ! cerebral cortex cell migration

[Term]
id: GO:0021800
name: cerebral cortex tangential migration
namespace: biological_process
def: "The migration of cells in the cerebral cortex in which cells move orthogonally to the direction of radial migration and do not use radial glial cell processes as substrates for migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021795 ! cerebral cortex cell migration

[Term]
id: GO:0021801
name: cerebral cortex radial glia guided migration
namespace: biological_process
def: "The radial migration of neuronal or glial precursor cells along radial glial cells during the development of the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "glial-guided locomotion" RELATED [PMID:12626695]
is_a: GO:0021799 ! cerebral cortex radially oriented cell migration
is_a: GO:0022030 ! telencephalon glial cell migration

[Term]
id: GO:0021802
name: somal translocation
namespace: biological_process
def: "The radial migration of cells from the ventricular zone that is independent of radial glial cells. Cells extend processes that terminate at the pial surface and follow the processes as they migrate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "perikaryal translocation of Morest" EXACT [PMID:12626695]
is_a: GO:0021799 ! cerebral cortex radially oriented cell migration

[Term]
id: GO:0021803
name: pial surface process extension
namespace: biological_process
def: "The extension of a long process to the pial surface as a cell leaves the ventricular zone." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0030031 ! cell projection assembly
relationship: part_of GO:0021802 ! somal translocation

[Term]
id: GO:0021804
name: negative regulation of cell adhesion in ventricular zone
namespace: biological_process
def: "The process that results in the loss of attachments of a cell in the ventricular zone." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "down regulation of cell adhesion in ventricular zone" EXACT []
synonym: "down-regulation of cell adhesion in ventricular zone" EXACT []
synonym: "downregulation of cell adhesion in ventricular zone" EXACT []
synonym: "inhibition of cell adhesion in ventricular zone" NARROW []
is_a: GO:0007162 ! negative regulation of cell adhesion
relationship: part_of GO:0021802 ! somal translocation

[Term]
id: GO:0021805
name: cell movement involved in somal translocation
namespace: biological_process
def: "The movement of a cell body from the ventricular zone to the pial surface with a concomitant shortening of the process that extends to the pial surface." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "cell motility involved in somal translocation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0048870 ! cell motility
intersection_of: GO:0048870 ! cell motility
intersection_of: part_of GO:0021802 ! somal translocation
relationship: part_of GO:0021802 ! somal translocation

[Term]
id: GO:0021806
name: initiation of movement involved in cerebral cortex radial glia guided migration
namespace: biological_process
def: "The initial stages of cell motility involved in the glial-mediated movement of cells in the developing cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "initiation of movement involved in cerebral cortex glial-mediated radial migration" RELATED [GOC:dph]
is_a: GO:0048869 ! cellular developmental process
relationship: part_of GO:0001667 ! ameboidal-type cell migration
relationship: part_of GO:0021814 ! cell motility involved in cerebral cortex radial glia guided migration

[Term]
id: GO:0021807
name: motogenic signaling initiating cell movement in cerebral cortex
namespace: biological_process
def: "The interaction of soluble factors and receptors that result in the movement of cells in the primitive cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "motogenic signalling initiating cell movement in the cerebral cortex" EXACT []
is_a: GO:0007154 ! cell communication
is_a: GO:0044700 ! single organism signaling
relationship: part_of GO:0021806 ! initiation of movement involved in cerebral cortex radial glia guided migration

[Term]
id: GO:0021808
name: cytosolic calcium signaling involved in initiation of cell movement in glial-mediated radial cell migration
namespace: biological_process
def: "The process that results in the fluctuations in intracellular calcium that are responsible for the initiation of movement as a component of the process of cerebral cortex glial-mediated radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "cytosolic calcium signalling involved in the initiation of cell movement in glial-mediated radial cell migration" EXACT []
is_a: GO:0019722 ! calcium-mediated signaling
relationship: part_of GO:0021806 ! initiation of movement involved in cerebral cortex radial glia guided migration

[Term]
id: GO:0021809
name: neurotrophic factor signaling initiating cell movement, involved in cerebral cortex radial glia guided migration
namespace: biological_process
def: "Signaling between members of the neurotrophin family and their receptors that result in the start of cell motility as a component of the process of cerebral cortex glial-mediated radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "neurotrophic factor signalling initiating cell movement, involved in cerebral cortex glial-mediated radial migration" EXACT []
is_a: GO:0021807 ! motogenic signaling initiating cell movement in cerebral cortex

[Term]
id: GO:0021810
name: neurotransmitter signaling initiating cell movement, involved in cerebral cortex radial glia guided migration
namespace: biological_process
def: "Signaling by neurotransmitters and their receptors that results in the initiation of movement of cells as a component of the process of glial-mediated radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "neurotransmitter signalling initiating cell movement, involved in cerebral cortex glial-mediated radial migration" EXACT []
is_a: GO:0021807 ! motogenic signaling initiating cell movement in cerebral cortex

[Term]
id: GO:0021811
name: growth factor signaling initiating cell movement involved in cerebral cortex radial glia guided migration
namespace: biological_process
def: "Signaling between growth factors and their receptors that results in the start of cell movement, where this process is involved in glial-mediated radial migration in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "growth factor signaling initiating cell movement involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:mtg_cardio]
synonym: "growth factor signalling initiating cell movement involved in cerebral cortex glial-mediated radial migration" EXACT []
is_a: GO:0021807 ! motogenic signaling initiating cell movement in cerebral cortex

[Term]
id: GO:0021812
name: neuronal-glial interaction involved in cerebral cortex radial glia guided migration
namespace: biological_process
def: "The changes in adhesion between neuronal cells and glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "neuronal-glial interaction involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph]
is_a: GO:0016337 ! single organismal cell-cell adhesion
relationship: part_of GO:0021801 ! cerebral cortex radial glia guided migration

[Term]
id: GO:0021813
name: cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration
namespace: biological_process
def: "The interaction between two cells that modulates the association of a neuronal cell and a glial cell involved in glial-mediated radial cell migration in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph]
is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules
intersection_of: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules
intersection_of: part_of GO:0021812 ! neuronal-glial interaction involved in cerebral cortex radial glia guided migration
relationship: part_of GO:0021812 ! neuronal-glial interaction involved in cerebral cortex radial glia guided migration

[Term]
id: GO:0021814
name: cell motility involved in cerebral cortex radial glia guided migration
namespace: biological_process
def: "The movement of a cell along the process of a radial glial cell involved in cerebral cortex glial-mediated radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "cell locomotion involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph]
synonym: "cell locomotion involved in cerebral cortex radial glia guided migration" RELATED [GOC:dph]
is_a: GO:0048870 ! cell motility
intersection_of: GO:0048870 ! cell motility
intersection_of: part_of GO:0021801 ! cerebral cortex radial glia guided migration
relationship: part_of GO:0021801 ! cerebral cortex radial glia guided migration

[Term]
id: GO:0021815
name: modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration
namespace: biological_process
def: "Rearrangements of the microtubule cytoskeleton that contribute to the movement of cells along radial glial cells as a component of the process of cerebral cortex glial-mediated radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "modulation of microtubule cytoskeleton involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph]
is_a: GO:0000226 ! microtubule cytoskeleton organization
intersection_of: GO:0000226 ! microtubule cytoskeleton organization
intersection_of: part_of GO:0021801 ! cerebral cortex radial glia guided migration
relationship: part_of GO:0021801 ! cerebral cortex radial glia guided migration
relationship: part_of GO:0021814 ! cell motility involved in cerebral cortex radial glia guided migration

[Term]
id: GO:0021816
name: extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration
namespace: biological_process
def: "The rearrangements of the microtubule cytoskeleton that result in the extension of a leading process, where this process is involved in the movement of cells along radial glial cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021815 ! modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration
is_a: GO:0031269 ! pseudopodium assembly

[Term]
id: GO:0021817
name: nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration
namespace: biological_process
def: "The microtubule-mediated movement of the nucleus that is required for the movement of cells along radial glial fibers as a component of the process of cerebral cortex glial-mediated radial cell migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "nucleokinesis involved in cell locomotion in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph]
synonym: "nucleokinesis involved in cell locomotion in cerebral cortex radial glia guided migration" RELATED [GOC:dph, GOC:tb]
is_a: GO:0030473 ! nuclear migration along microtubule
relationship: part_of GO:0021815 ! modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration

[Term]
id: GO:0021818
name: modulation of the microfilament cytoskeleton involved in cell locomotion in cerebral cortex radial glia guided migration
namespace: biological_process
def: "The changes in the actin cytoskeleton that are necessary for the movement of cells along radial glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "modulation of the microfilament cytoskeleton involved in cell locomotion in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph]
is_a: GO:0030036 ! actin cytoskeleton organization
relationship: part_of GO:0021814 ! cell motility involved in cerebral cortex radial glia guided migration

[Term]
id: GO:0021819
name: layer formation in cerebral cortex
namespace: biological_process
def: "The detachment of cells from radial glial fibers at the appropriate time when they cease to migrate and form distinct layer in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "cerebral cortex lamination" RELATED [PMID:12626695]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021801 ! cerebral cortex radial glia guided migration

[Term]
id: GO:0021820
name: extracellular matrix organization in marginal zone involved in cerebral cortex radial glia guided migration
namespace: biological_process
def: "The process that leads to the deposition of extracellular matrix signals in the marginal zone of the developing cerebral cortex. This extracellular matrix controls the movement of migrating cells. In mammals, the matrix is modified by Cajal-Retzius cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "extracellular matrix organisation in marginal zone involved in cerebral cortex radial glia guided migration" EXACT [GOC:mah]
synonym: "organization of extracellular matrix in the marginal zone involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph]
is_a: GO:0030198 ! extracellular matrix organization
relationship: part_of GO:0021819 ! layer formation in cerebral cortex

[Term]
id: GO:0021821
name: negative regulation of cell-glial cell adhesion involved in cerebral cortex lamination
namespace: biological_process
def: "The process that results in the release of migrating cells from their interaction with radial glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "down regulation of cell-glial cell adhesion involved in cerebral cortex lamination" EXACT []
synonym: "down-regulation of cell-glial cell adhesion involved in cerebral cortex lamination" EXACT []
synonym: "downregulation of cell-glial cell adhesion involved in cerebral cortex lamination" EXACT []
synonym: "inhibition of cell-glial cell adhesion involved in cerebral cortex lamination" NARROW []
is_a: GO:0022408 ! negative regulation of cell-cell adhesion
relationship: part_of GO:0021819 ! layer formation in cerebral cortex

[Term]
id: GO:0021822
name: negative regulation of cell motility involved in cerebral cortex radial glia guided migration
namespace: biological_process
def: "The intracellular signaling pathway that results in the cessation of cell movement involved in lamination of the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "down regulation of cell locomotion involved in cerebral cortex glial-mediated radial cell migration" EXACT []
synonym: "down-regulation of cell locomotion involved in cerebral cortex glial-mediated radial cell migration" EXACT []
synonym: "downregulation of cell locomotion involved in cerebral cortex glial-mediated radial cell migration" EXACT []
synonym: "inhibition of cell locomotion involved in cerebral cortex glial-mediated radial cell migration" NARROW []
synonym: "negative regulation of cell locomotion involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph]
synonym: "negative regulation of cell locomotion involved in cerebral cortex radial glia guided migration" RELATED [GOC:dph, GOC:tb]
is_a: GO:1903976 ! negative regulation of glial cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0021814 ! cell motility involved in cerebral cortex radial glia guided migration
relationship: negatively_regulates GO:0021814 ! cell motility involved in cerebral cortex radial glia guided migration
relationship: part_of GO:0021819 ! layer formation in cerebral cortex

[Term]
id: GO:0021823
name: cerebral cortex tangential migration using cell-cell interactions
namespace: biological_process
def: "The process in which neurons interact with each other to promote migration along a tangential plane." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "chain migration" RELATED [PMID:12626695]
is_a: GO:0021825 ! substrate-dependent cerebral cortex tangential migration

[Term]
id: GO:0021824
name: cerebral cortex tangential migration using cell-axon interactions
namespace: biological_process
def: "The movement of cerebral cortex neuronal precursors tangentially through the cortex using interaction of the migrating cells with axons of other neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021825 ! substrate-dependent cerebral cortex tangential migration

[Term]
id: GO:0021825
name: substrate-dependent cerebral cortex tangential migration
namespace: biological_process
def: "The process where neuronal precursors migrate tangentially in the cerebral cortex, primarily guided through physical cell-cell interactions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0006929 ! substrate-dependent cell migration
is_a: GO:0021800 ! cerebral cortex tangential migration

[Term]
id: GO:0021826
name: substrate-independent telencephalic tangential migration
namespace: biological_process
def: "The process where neuronal precursors migrate tangentially in the telencephalon, primarily guided by interactions that do not require cell-cell contact." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0022029 ! telencephalon cell migration

[Term]
id: GO:0021827
name: postnatal olfactory bulb interneuron migration
namespace: biological_process
def: "The migration of olfactory bulb interneuron precursors in the cerebral cortex that occurs after birth." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021823 ! cerebral cortex tangential migration using cell-cell interactions
is_a: GO:0022028 ! tangential migration from the subventricular zone to the olfactory bulb
relationship: part_of GO:0021891 ! olfactory bulb interneuron development

[Term]
id: GO:0021828
name: gonadotrophin-releasing hormone neuronal migration to the hypothalamus
namespace: biological_process
alt_id: GO:0021857
def: "The directional movement of a gonadotrophin-releasing hormone producing neuron from the nasal placode to the hypothalamus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "gonadotropin-releasing hormone neuronal migration to the hypothalamus" EXACT [GOC:dph]
is_a: GO:0001764 ! neuron migration
is_a: GO:0021824 ! cerebral cortex tangential migration using cell-axon interactions
is_a: GO:0021856 ! hypothalamic tangential migration using cell-axon interactions
relationship: part_of GO:0021888 ! hypothalamus gonadotrophin-releasing hormone neuron development

[Term]
id: GO:0021829
name: oligodendrocyte cell migration from the subpallium to the cortex
namespace: biological_process
def: "The directed movement of oligodendrocytes from the subpallium to the cerebral cortex during forebrain development." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021826 ! substrate-independent telencephalic tangential migration
is_a: GO:0022030 ! telencephalon glial cell migration

[Term]
id: GO:0021830
name: interneuron migration from the subpallium to the cortex
namespace: biological_process
def: "The directed movement of interneurons from the subpallium to the cortex during forebrain development." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021843 ! substrate-independent telencephalic tangential interneuron migration

[Term]
id: GO:0021831
name: embryonic olfactory bulb interneuron precursor migration
namespace: biological_process
def: "The directed movement of individual interneuron precursors during the embryonic development of the olfactory bulb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021843 ! substrate-independent telencephalic tangential interneuron migration
is_a: GO:0022028 ! tangential migration from the subventricular zone to the olfactory bulb
relationship: part_of GO:0021891 ! olfactory bulb interneuron development

[Term]
id: GO:0021832
name: cell-cell adhesion involved in cerebral cortex tangential migration using cell-cell interactions
namespace: biological_process
def: "The attachment of cells to one another to form groups of cells involved in cerebral cortex tangential migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0016337 ! single organismal cell-cell adhesion
is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules
intersection_of: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules
intersection_of: part_of GO:0021823 ! cerebral cortex tangential migration using cell-cell interactions
relationship: part_of GO:0021823 ! cerebral cortex tangential migration using cell-cell interactions

[Term]
id: GO:0021833
name: cell-matrix adhesion involved in tangential migration using cell-cell interactions
namespace: biological_process
def: "The interaction of a cell and the extracellular matrix involved in the directed tangential movement of cells mediated by cell-cell interactions in the developing cerebral cortex." [GO_REF:0000021, GOC:ascb_2009, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0031589 ! cell-substrate adhesion
relationship: part_of GO:0021823 ! cerebral cortex tangential migration using cell-cell interactions

[Term]
id: GO:0021834
name: chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration
namespace: biological_process
def: "The creation and reception of signals that guide olfactory bulb interneuron precursors down concentration gradients towards the olfactory bulb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "negative chemotaxis involved in embryonic olfactory bulb interneuron precursor migration" EXACT [GOC:mah]
is_a: GO:0050919 ! negative chemotaxis
intersection_of: GO:0050919 ! negative chemotaxis
intersection_of: part_of GO:0021831 ! embryonic olfactory bulb interneuron precursor migration
relationship: part_of GO:0021831 ! embryonic olfactory bulb interneuron precursor migration

[Term]
id: GO:0021835
name: chemoattraction involved in embryonic olfactory bulb interneuron precursor migration
namespace: biological_process
def: "The creation and reception of signals that result in the migration of interneuron precursors up a concentration gradient towards the olfactory bulb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "positive chemotaxis involved in embryonic olfactory bulb interneuron precursor migration" EXACT [GOC:mah]
is_a: GO:0050918 ! positive chemotaxis
intersection_of: GO:0050918 ! positive chemotaxis
intersection_of: part_of GO:0021831 ! embryonic olfactory bulb interneuron precursor migration
relationship: part_of GO:0021831 ! embryonic olfactory bulb interneuron precursor migration

[Term]
id: GO:0021836
name: chemorepulsion involved in postnatal olfactory bulb interneuron migration
namespace: biological_process
def: "The creation and reception of signals that repel olfactory bulb interneurons from the subventricular zone as a component process in tangential migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "negative chemotaxis involved in postnatal olfactory bulb interneuron migration" EXACT [GOC:mah]
is_a: GO:0050919 ! negative chemotaxis
intersection_of: GO:0050919 ! negative chemotaxis
intersection_of: part_of GO:0021827 ! postnatal olfactory bulb interneuron migration
relationship: part_of GO:0021827 ! postnatal olfactory bulb interneuron migration

[Term]
id: GO:0021837
name: motogenic signaling involved in postnatal olfactory bulb interneuron migration
namespace: biological_process
def: "The signaling that results in the stimulation of cell movement in the rostral migratory stream." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "motogenic signalling involved in postnatal olfactory bulb interneuron migration" EXACT []
is_a: GO:0007154 ! cell communication
is_a: GO:0044700 ! single organism signaling
relationship: part_of GO:0021827 ! postnatal olfactory bulb interneuron migration

[Term]
id: GO:0021838
name: motogenic signaling involved in interneuron migration from the subpallium to the cortex
namespace: biological_process
def: "The creation and reception of signals that result in the directional movement of interneuron precursors from the subpallium to the cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "motogenic signalling involved in interneuron migration from the subpallium to the cortex" EXACT []
is_a: GO:0007154 ! cell communication
is_a: GO:0044700 ! single organism signaling
relationship: part_of GO:0021830 ! interneuron migration from the subpallium to the cortex

[Term]
id: GO:0021839
name: interneuron-substratum interaction involved in interneuron migration from the subpallium to the cortex
namespace: biological_process
def: "The process in which migrating interneurons interact with an external substratum as a component of migration from the subpallium to the cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0031589 ! cell-substrate adhesion
relationship: part_of GO:0021830 ! interneuron migration from the subpallium to the cortex

[Term]
id: GO:0021840
name: directional guidance of interneurons involved in migration from the subpallium to the cortex
namespace: biological_process
def: "The creation and reception of signals that control the direction of migration of interneurons as a component of the process of migration from the subpallium to the cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0030334 ! regulation of cell migration
relationship: part_of GO:0021830 ! interneuron migration from the subpallium to the cortex

[Term]
id: GO:0021841
name: chemoattraction involved in interneuron migration from the subpallium to the cortex
namespace: biological_process
def: "The creation and reception of signals that result in the movement of interneurons toward the signal, where this process is involved in migration from the subpallium to the cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "positive chemotaxis involved in interneuron migration from the subpallium to the cortex" EXACT [GOC:mah]
is_a: GO:0050918 ! positive chemotaxis
intersection_of: GO:0050918 ! positive chemotaxis
intersection_of: part_of GO:0021830 ! interneuron migration from the subpallium to the cortex
relationship: part_of GO:0021830 ! interneuron migration from the subpallium to the cortex
relationship: part_of GO:0021840 ! directional guidance of interneurons involved in migration from the subpallium to the cortex

[Term]
id: GO:0021842
name: chemorepulsion involved in interneuron migration from the subpallium to the cortex
namespace: biological_process
def: "The creation and reception of signals that result in the movement of interneurons away from the signal during migration from the subpallium to the cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "negative chemotaxis involved in interneuron migration from the subpallium to the cortex" EXACT [GOC:mah]
is_a: GO:0050919 ! negative chemotaxis
intersection_of: GO:0050919 ! negative chemotaxis
intersection_of: part_of GO:0021830 ! interneuron migration from the subpallium to the cortex
relationship: part_of GO:0021830 ! interneuron migration from the subpallium to the cortex
relationship: part_of GO:0021840 ! directional guidance of interneurons involved in migration from the subpallium to the cortex

[Term]
id: GO:0021843
name: substrate-independent telencephalic tangential interneuron migration
namespace: biological_process
def: "The directional movement of tangentially migrating interneurons that are not guided by attaching to extracellular substrates." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021826 ! substrate-independent telencephalic tangential migration

[Term]
id: GO:0021844
name: interneuron sorting involved in substrate-independent cerebral cortex tangential migration
namespace: biological_process
def: "The establishment and response to guidance cues that distribute interneurons to different cerebral cortex structures." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0042330 ! taxis
relationship: part_of GO:0021843 ! substrate-independent telencephalic tangential interneuron migration

[Term]
id: GO:0021845
name: neurotransmitter-mediated guidance of interneurons involved in substrate-independent cerebral cortex tangential migration
namespace: biological_process
def: "The response of migrating interneurons to neurotransmitters that alter electrical activity in cells in calcium dependent manner." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0030334 ! regulation of cell migration
relationship: part_of GO:0021843 ! substrate-independent telencephalic tangential interneuron migration

[Term]
id: GO:0021846
name: cell proliferation in forebrain
namespace: biological_process
def: "The creation of greater cell numbers in the forebrain due to cell division of progenitor cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0061351 ! neural precursor cell proliferation
relationship: part_of GO:0030900 ! forebrain development

[Term]
id: GO:0021847
name: ventricular zone neuroblast division
namespace: biological_process
def: "The proliferation of neuroblasts in the ventricular zone of the cerebral cortex. The neuronal progenitors of these cells will migrate radially." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "neuroblast division in ventricular zone" EXACT [GOC:curators]
is_a: GO:0021869 ! forebrain ventricular zone progenitor cell division
is_a: GO:0021873 ! forebrain neuroblast division

[Term]
id: GO:0021848
name: neuroblast division in subpallium
namespace: biological_process
def: "The division of neuroblasts in the subpallium area of the forebrain. The interneuron precursors that these cells give rise to include GABAergic interneurons and will migrate tangentially." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "neuroblast division in the ventral telencephalon" EXACT [PMID:16226447]
is_a: GO:0021873 ! forebrain neuroblast division
relationship: part_of GO:0022012 ! subpallium cell proliferation in forebrain

[Term]
id: GO:0021849
name: neuroblast division in subventricular zone
namespace: biological_process
def: "The division of neuroblasts in the subventricular zone of the forebrain. The interneuron precursors that these cells give rise to include adult olfactory bulb interneurons and migrate tangentially." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021873 ! forebrain neuroblast division
relationship: part_of GO:0021846 ! cell proliferation in forebrain

[Term]
id: GO:0021850
name: subpallium glioblast cell division
namespace: biological_process
def: "The division of glioblasts in the subpallium. These cells will give rise to oligodendrocytes." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "glioblast cell division in subpallium" EXACT [GOC:curators]
synonym: "glioblast division in ventral telencephalon" EXACT [PMID:16226447]
is_a: GO:0048860 ! glioblast division
relationship: part_of GO:0022012 ! subpallium cell proliferation in forebrain

[Term]
id: GO:0021851
name: neuroblast division in dorsal lateral ganglionic eminence
namespace: biological_process
def: "The division of neuroblasts in the dorsal region of the lateral ganglionic eminence. These cells give rise to embryonic interneuron precursors that will migrate tangentially to the olfactory bulb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021848 ! neuroblast division in subpallium

[Term]
id: GO:0021852
name: pyramidal neuron migration
namespace: biological_process
def: "The migration of pyramidal a neuron precursor from the ventricular zone to the correct layer of the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "projection neuron migration" RELATED [PMID:12626695]
is_a: GO:0001764 ! neuron migration
is_a: GO:0021801 ! cerebral cortex radial glia guided migration
relationship: part_of GO:0021860 ! pyramidal neuron development

[Term]
id: GO:0021853
name: cerebral cortex GABAergic interneuron migration
namespace: biological_process
def: "The migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021830 ! interneuron migration from the subpallium to the cortex
is_a: GO:1904936 ! interneuron migration
relationship: part_of GO:0021894 ! cerebral cortex GABAergic interneuron development

[Term]
id: GO:0021854
name: hypothalamus development
namespace: biological_process
def: "The progression of the hypothalamus region of the forebrain, from its initial formation to its mature state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021536 ! diencephalon development
relationship: part_of GO:0021761 ! limbic system development

[Term]
id: GO:0021855
name: hypothalamus cell migration
namespace: biological_process
def: "The directed movement of a cell into the hypothalamus region of the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0016477 ! cell migration
relationship: part_of GO:0021854 ! hypothalamus development

[Term]
id: GO:0021856
name: hypothalamic tangential migration using cell-axon interactions
namespace: biological_process
def: "The movement of a hypothalamic neuronal precursor tangentially through the forebrain using an interaction of the migrating cells with axons of other neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021855 ! hypothalamus cell migration

[Term]
id: GO:0021858
name: GABAergic neuron differentiation in basal ganglia
namespace: biological_process
def: "The process in which a neuroblast acquires the specialized structural and functional features of a GABAergic inhibitory neuron in the basal ganglia. Differentiation includes the processes involved in commitment of a neuroblast to a GABAergic neuron." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447]
comment: This term was added by GO_REF:0000021.
is_a: GO:0097154 ! GABAergic neuron differentiation

[Term]
id: GO:0021859
name: pyramidal neuron differentiation
namespace: biological_process
def: "The process in which a neuroblast or one of its progeny commits to a pyramidal neuron fate, migrates from the ventricular zone to the appropriate layer in the cortex and develops into a mature neuron." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "projection neuron differentiation" BROAD [PMID:16226447]
is_a: GO:0021953 ! central nervous system neuron differentiation

[Term]
id: GO:0021860
name: pyramidal neuron development
namespace: biological_process
def: "The progression of a pyramidal neuron from its initial formation to its mature state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "projection neuron development" BROAD [PMID:16226447]
is_a: GO:0021884 ! forebrain neuron development
relationship: part_of GO:0021859 ! pyramidal neuron differentiation

[Term]
id: GO:0021861
name: forebrain radial glial cell differentiation
namespace: biological_process
def: "The process in which neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the forebrain. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447]
comment: This term was added by GO_REF:0000021.
synonym: "radial glial cell differentiation in forebrain" EXACT [GOC:curators]
is_a: GO:0060019 ! radial glial cell differentiation
relationship: part_of GO:0021872 ! forebrain generation of neurons

[Term]
id: GO:0021862
name: early neuron differentiation in forebrain
namespace: biological_process
def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of neurons. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021879 ! forebrain neuron differentiation

[Term]
id: GO:0021863
name: forebrain neuroblast differentiation
namespace: biological_process
def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of basal progenitor cells, neuroblasts that lose their contacts with the ventricular surface. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447]
comment: This term was added by GO_REF:0000021.
synonym: "abventricular progenitor cell differentiation" EXACT [PMID:16226447]
synonym: "intermediate progenitor cell differentiation" EXACT [PMID:16226447]
synonym: "non-surface dividing progenitor cell differentiation" EXACT [PMID:16226447]
is_a: GO:0014016 ! neuroblast differentiation
relationship: part_of GO:0021872 ! forebrain generation of neurons

[Term]
id: GO:0021864
name: radial glial cell division in forebrain
namespace: biological_process
def: "The mitotic division of radial glial cells in the developing forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447]
comment: This term was added by GO_REF:0000021.
is_a: GO:0051301 ! cell division
relationship: part_of GO:0021846 ! cell proliferation in forebrain

[Term]
id: GO:0021865
name: symmetric radial glial cell division in forebrain
namespace: biological_process
def: "The mitotic division of a radial glial cell giving rise to two new radial glial cells in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021864 ! radial glial cell division in forebrain

[Term]
id: GO:0021866
name: asymmetric radial glial cell division in forebrain
namespace: biological_process
def: "The mitotic cell division of a radial glial cell giving rise to a radial glial cell and another cell type." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021864 ! radial glial cell division in forebrain

[Term]
id: GO:0021867
name: neuron-producing asymmetric radial glial cell division in forebrain
namespace: biological_process
def: "The unequal mitotic division of a radial glial cell in the forebrain that gives rise to a radial glial cell and a post-mitotic neuronal progenitor." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021866 ! asymmetric radial glial cell division in forebrain

[Term]
id: GO:0021868
name: ventricular zone cell-producing asymmetric radial glial cell division in forebrain
namespace: biological_process
def: "The unequal mitotic division of a forebrain radial glial cell that gives rise to a radial glial cell and a ventricular zone cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021866 ! asymmetric radial glial cell division in forebrain

[Term]
id: GO:0021869
name: forebrain ventricular zone progenitor cell division
namespace: biological_process
def: "The mitotic division of a basal progenitor giving rise to two neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447]
comment: This term was added by GO_REF:0000021.
is_a: GO:0051301 ! cell division
relationship: part_of GO:0021846 ! cell proliferation in forebrain

[Term]
id: GO:0021870
name: Cajal-Retzius cell differentiation
namespace: biological_process
def: "The process in which a neuroblast acquires specialized structural and/or functional features of a Cajal-Retzius cell, one of a transient population of pioneering neurons in the cerebral cortex. These cells are slender bipolar cells of the developing marginal zone. One feature of these cells in mammals is that they express the Reelin gene." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021895 ! cerebral cortex neuron differentiation

[Term]
id: GO:0021871
name: forebrain regionalization
namespace: biological_process
def: "The regionalization process resulting in the creation of areas within the forebrain that will direct the behavior of cell migration in differentiation as the forebrain develops." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:isa_complete, GOC:jid, GOC:mtg_15jun06, PMID:16226447]
comment: This term was added by GO_REF:0000021.
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0030900 ! forebrain development

[Term]
id: GO:0021872
name: forebrain generation of neurons
namespace: biological_process
def: "The process in which nerve cells are generated in the forebrain. This includes the production of neuroblasts from and their differentiation into neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "generation of neurons in forebrain" EXACT [GOC:curators]
is_a: GO:0048699 ! generation of neurons
relationship: part_of GO:0030900 ! forebrain development

[Term]
id: GO:0021873
name: forebrain neuroblast division
namespace: biological_process
def: "The division of a neuroblast located in the forebrain. Neuroblast division gives rise to at least another neuroblast." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0055057 ! neuroblast division
relationship: part_of GO:0021872 ! forebrain generation of neurons

[Term]
id: GO:0021874
name: Wnt signaling pathway involved in forebrain neuroblast division
namespace: biological_process
def: "The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell that contributes to the self renewal of neuroblasts in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447]
comment: This term was added by GO_REF:0000021.
synonym: "Wnt receptor signaling pathway involved in forebrain neuroblast division" EXACT []
synonym: "Wnt receptor signalling pathway in forebrain neuroblast division" EXACT []
synonym: "Wnt-activated signaling pathway involved in forebrain neuroblast division" EXACT [GOC:signaling]
is_a: GO:0016055 ! Wnt signaling pathway
intersection_of: GO:0016055 ! Wnt signaling pathway
intersection_of: part_of GO:0021873 ! forebrain neuroblast division
relationship: part_of GO:0021873 ! forebrain neuroblast division

[Term]
id: GO:0021875
name: fibroblast growth factor receptor signaling pathway involved in forebrain neuroblast division
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to the self renewal of neuroblasts in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447]
comment: This term was added by GO_REF:0000021.
synonym: "fibroblast growth factor receptor signalling pathway in forebrain neuroblast division" EXACT []
is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway
intersection_of: GO:0008543 ! fibroblast growth factor receptor signaling pathway
intersection_of: part_of GO:0021873 ! forebrain neuroblast division
relationship: part_of GO:0021873 ! forebrain neuroblast division

[Term]
id: GO:0021876
name: Notch signaling pathway involved in forebrain neuroblast division
namespace: biological_process
def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to the self renewal of neuroblasts in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447]
comment: This term was added by GO_REF:0000021.
synonym: "Notch signalling pathway in forebrain neuroblast division" EXACT []
is_a: GO:0007219 ! Notch signaling pathway
intersection_of: GO:0007219 ! Notch signaling pathway
intersection_of: part_of GO:0021873 ! forebrain neuroblast division
relationship: part_of GO:0021873 ! forebrain neuroblast division

[Term]
id: GO:0021877
name: forebrain neuron fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron that resides in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048663 ! neuron fate commitment
relationship: part_of GO:0021879 ! forebrain neuron differentiation

[Term]
id: GO:0021878
name: forebrain astrocyte fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into an astrocyte that resides in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447]
comment: This term was added by GO_REF:0000021.
is_a: GO:0060018 ! astrocyte fate commitment
relationship: part_of GO:0021896 ! forebrain astrocyte differentiation

[Term]
id: GO:0021879
name: forebrain neuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron that will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021953 ! central nervous system neuron differentiation
relationship: part_of GO:0021872 ! forebrain generation of neurons

[Term]
id: GO:0021880
name: Notch signaling pathway involved in forebrain neuron fate commitment
namespace: biological_process
def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447]
comment: This term was added by GO_REF:0000021.
synonym: "Notch signalling pathway involved in forebrain neuron fate commitment" EXACT []
is_a: GO:0007219 ! Notch signaling pathway
intersection_of: GO:0007219 ! Notch signaling pathway
intersection_of: part_of GO:0021877 ! forebrain neuron fate commitment
relationship: part_of GO:0021877 ! forebrain neuron fate commitment
relationship: part_of GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain

[Term]
id: GO:0021881
name: Wnt-activated signaling pathway involved in forebrain neuron fate commitment
namespace: biological_process
def: "The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell that contributes to the commitment of a neuroblast to aneuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447]
comment: This term was added by GO_REF:0000021.
synonym: "Wnt receptor signaling pathway involved in forebrain neuron fate commitment" EXACT []
synonym: "Wnt receptor signalling pathway involved in forebrain neuron fate commitment" EXACT []
synonym: "Wnt-activated signaling pathway involved in forebrain neuron fate commitment" RELATED [GOC:signaling]
is_a: GO:0016055 ! Wnt signaling pathway
intersection_of: GO:0016055 ! Wnt signaling pathway
intersection_of: part_of GO:0021877 ! forebrain neuron fate commitment
relationship: part_of GO:0021877 ! forebrain neuron fate commitment
relationship: part_of GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain

[Term]
id: GO:0021882
name: regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447]
comment: This term was added by GO_REF:0000021.
is_a: GO:0060850 ! regulation of transcription involved in cell fate commitment
intersection_of: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
intersection_of: part_of GO:0021877 ! forebrain neuron fate commitment
relationship: part_of GO:0021877 ! forebrain neuron fate commitment
relationship: part_of GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain

[Term]
id: GO:0021883
name: cell cycle arrest of committed forebrain neuronal progenitor cell
namespace: biological_process
def: "The process in which the cell cycle is halted during one of the normal phases (G1, S, G2, M) in a cell that has been committed to become a neuron that will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb, PMID:16226447]
comment: This term was added by GO_REF:0000021.
is_a: GO:0007050 ! cell cycle arrest
relationship: part_of GO:0021879 ! forebrain neuron differentiation

[Term]
id: GO:0021884
name: forebrain neuron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a neuron that resides in the forebrain, from its initial commitment to its fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021954 ! central nervous system neuron development
relationship: part_of GO:0021879 ! forebrain neuron differentiation

[Term]
id: GO:0021885
name: forebrain cell migration
namespace: biological_process
def: "The orderly movement of a cell from one site to another at least one of which is located in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0016477 ! cell migration
relationship: part_of GO:0030900 ! forebrain development

[Term]
id: GO:0021886
name: hypothalamus gonadotrophin-releasing hormone neuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron located in the hypothalamus. These neurons release gonadotrophin-releasing hormone as a neural transmitter." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "hypothalamus gonadotropin-releasing hormone neuron differentiation" EXACT [GOC:dph]
is_a: GO:0021979 ! hypothalamus cell differentiation

[Term]
id: GO:0021887
name: hypothalamus gonadotrophin-releasing hormone neuron fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a hypothalamus neuron that releases gonadotrophin-releasing hormone." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "hypothalamus gonadotropin-releasing hormone neuron fate commitment" RELATED [GOC:dph]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0021886 ! hypothalamus gonadotrophin-releasing hormone neuron differentiation

[Term]
id: GO:0021888
name: hypothalamus gonadotrophin-releasing hormone neuron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a hypothalamus gonadotrophin-releasing hormone neuron over time, from initial commitment of its fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "hypothalamus gonadotropin-releasing hormone neuron development" RELATED [GOC:dph]
is_a: GO:0021884 ! forebrain neuron development
relationship: part_of GO:0021886 ! hypothalamus gonadotrophin-releasing hormone neuron differentiation

[Term]
id: GO:0021889
name: olfactory bulb interneuron differentiation
namespace: biological_process
def: "The process in which a neuroblast acquires specialized features of an interneuron residing in the olfactory bulb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021879 ! forebrain neuron differentiation
relationship: part_of GO:0021772 ! olfactory bulb development

[Term]
id: GO:0021890
name: olfactory bulb interneuron fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a neuroblast becomes restricted such that it will develop into an interneuron residing in the olfactory bulb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048663 ! neuron fate commitment
relationship: part_of GO:0021889 ! olfactory bulb interneuron differentiation

[Term]
id: GO:0021891
name: olfactory bulb interneuron development
namespace: biological_process
def: "The process whose specific outcome is the progression of an interneuron residing in the olfactory bulb, from its initial commitment, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021884 ! forebrain neuron development
relationship: part_of GO:0021889 ! olfactory bulb interneuron differentiation

[Term]
id: GO:0021892
name: cerebral cortex GABAergic interneuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a GABAergic interneuron residing in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021879 ! forebrain neuron differentiation
is_a: GO:0021895 ! cerebral cortex neuron differentiation
is_a: GO:0097154 ! GABAergic neuron differentiation

[Term]
id: GO:0021893
name: cerebral cortex GABAergic interneuron fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a neuroblast becomes restricted such that it will develop into a GABAergic interneuron residing in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048663 ! neuron fate commitment
relationship: part_of GO:0021892 ! cerebral cortex GABAergic interneuron differentiation

[Term]
id: GO:0021894
name: cerebral cortex GABAergic interneuron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cerebral cortex GABAergic interneuron over time, from initial commitment to its fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021884 ! forebrain neuron development
relationship: part_of GO:0021892 ! cerebral cortex GABAergic interneuron differentiation

[Term]
id: GO:0021895
name: cerebral cortex neuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron residing in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021953 ! central nervous system neuron differentiation
relationship: part_of GO:0030900 ! forebrain development

[Term]
id: GO:0021896
name: forebrain astrocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte residing in the forebrain. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048708 ! astrocyte differentiation
relationship: part_of GO:0030900 ! forebrain development

[Term]
id: GO:0021897
name: forebrain astrocyte development
namespace: biological_process
def: "The process aimed at the progression of an astrocyte that resides in the forebrain, from initial commitment of the cell to its fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0014002 ! astrocyte development
relationship: part_of GO:0021896 ! forebrain astrocyte differentiation

[Term]
id: GO:0021898
name: commitment of multipotent stem cells to neuronal lineage in forebrain
namespace: biological_process
def: "The initial commitment of cells whereby the developmental fate of a cell becomes restricted such that it will develop into some type of neuron in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021877 ! forebrain neuron fate commitment

[Term]
id: GO:0021899
name: fibroblast growth factor receptor signaling pathway involved in forebrain neuron fate commitment
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447]
comment: This term was added by GO_REF:0000021.
synonym: "fibroblast growth factor receptor signalling pathway involved in forebrain neuron fate commitment" EXACT []
is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway
intersection_of: GO:0008543 ! fibroblast growth factor receptor signaling pathway
intersection_of: part_of GO:0021877 ! forebrain neuron fate commitment
relationship: part_of GO:0021877 ! forebrain neuron fate commitment
relationship: part_of GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain

[Term]
id: GO:0021900
name: ventricular zone cell fate commitment
namespace: biological_process
def: "The commitment of neuroblast to become a basal progenitor cell. Basal progenitor cells are neuronal precursor cells that are committed to becoming neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain
relationship: part_of GO:0021863 ! forebrain neuroblast differentiation

[Term]
id: GO:0021901
name: early neuron fate commitment in forebrain
namespace: biological_process
def: "The commitment of neuroepithelial cell to become a neuron that will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain
relationship: part_of GO:0021862 ! early neuron differentiation in forebrain

[Term]
id: GO:0021902
name: commitment of neuronal cell to specific neuron type in forebrain
namespace: biological_process
def: "The commitment of neuronal precursor cells to become specialized types of neurons in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021877 ! forebrain neuron fate commitment

[Term]
id: GO:0021903
name: rostrocaudal neural tube patterning
namespace: biological_process
def: "The process in which the neural tube is divided into specific regions along the rostrocaudal axis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869]
comment: This term was added by GO_REF:0000021.
synonym: "anterior-posterior neural tube patterning" RELATED [GOC:dph]
is_a: GO:0009952 ! anterior/posterior pattern specification
relationship: part_of GO:0021532 ! neural tube patterning

[Term]
id: GO:0021904
name: dorsal/ventral neural tube patterning
namespace: biological_process
def: "The process in which the neural tube is regionalized in the dorsoventral axis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869]
comment: This term was added by GO_REF:0000021.
synonym: "dorsal-ventral neural tube patterning" EXACT [GOC:dph]
synonym: "dorsoventral neural tube patterning" EXACT [GOC:mah]
is_a: GO:0009953 ! dorsal/ventral pattern formation
relationship: part_of GO:0021532 ! neural tube patterning

[Term]
id: GO:0021905
name: forebrain-midbrain boundary formation
namespace: biological_process
def: "The process whose specific outcome is the creation of the forebrain-midbrain boundary." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
is_a: GO:0048859 ! formation of anatomical boundary
relationship: part_of GO:0021903 ! rostrocaudal neural tube patterning

[Term]
id: GO:0021906
name: hindbrain-spinal cord boundary formation
namespace: biological_process
def: "The process whose specific outcome is the formation of the hindbrain-spinal cord boundary." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048859 ! formation of anatomical boundary
relationship: part_of GO:0021903 ! rostrocaudal neural tube patterning

[Term]
id: GO:0021907
name: fibroblast growth factor receptor signaling pathway involved in spinal cord anterior/posterior pattern formation
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869]
comment: This term was added by GO_REF:0000021.
synonym: "fibroblast growth factor receptor signalling pathway in spinal cord anterior-posterior patterning" EXACT []
is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway
intersection_of: GO:0008543 ! fibroblast growth factor receptor signaling pathway
intersection_of: part_of GO:0021512 ! spinal cord anterior/posterior patterning
relationship: part_of GO:0021512 ! spinal cord anterior/posterior patterning

[Term]
id: GO:0021908
name: retinoic acid receptor signaling pathway involved in spinal cord anterior/posterior pattern formation
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869]
comment: This term was added by GO_REF:0000021.
synonym: "retinoic acid receptor signalling pathway in spinal cord anterior-posterior patterning" EXACT []
is_a: GO:0048384 ! retinoic acid receptor signaling pathway
intersection_of: GO:0048384 ! retinoic acid receptor signaling pathway
intersection_of: part_of GO:0021512 ! spinal cord anterior/posterior patterning
relationship: part_of GO:0021512 ! spinal cord anterior/posterior patterning

[Term]
id: GO:0021909
name: regulation of transcription from RNA polymerase II promoter involved in spinal cord anterior-posterior patterning
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869]
comment: This term was added by GO_REF:0000021.
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
intersection_of: part_of GO:0021512 ! spinal cord anterior/posterior patterning
relationship: part_of GO:0021512 ! spinal cord anterior/posterior patterning

[Term]
id: GO:0021910
name: smoothened signaling pathway involved in ventral spinal cord patterning
namespace: biological_process
def: "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened that results in the spatial identity of regions along the dorsal-ventral axis of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb, PMID:11262869]
comment: This term was added by GO_REF:0000021.
synonym: "hedgehog signaling pathway involved in ventral spinal cord patterning" EXACT [GOC:bf, GOC:ecd]
synonym: "hh signaling pathway involved in ventral spinal cord patterning" EXACT [GOC:bf, GOC:ecd]
synonym: "smoothened signalling pathway in ventral spinal cord patterning" EXACT []
is_a: GO:0007224 ! smoothened signaling pathway
relationship: part_of GO:0021513 ! spinal cord dorsal/ventral patterning

[Term]
id: GO:0021911
name: retinoic acid metabolic process in spinal cord anterior-posterior patterning
namespace: biological_process
def: "The chemical reactions and pathways involving the synthesis and degradation of retionic acid that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869]
comment: This term was added by GO_REF:0000021.
synonym: "retinoic acid metabolism in spinal cord anterior-posterior patterning" EXACT []
is_a: GO:0042573 ! retinoic acid metabolic process
relationship: part_of GO:0021512 ! spinal cord anterior/posterior patterning

[Term]
id: GO:0021912
name: regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results the commitment of a cell to become a motor neuron in the ventral spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869]
comment: This term was added by GO_REF:0000021.
is_a: GO:0060850 ! regulation of transcription involved in cell fate commitment
relationship: part_of GO:0021520 ! spinal cord motor neuron cell fate specification

[Term]
id: GO:0021913
name: regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results in the commitment of a cell to become an interneuron in the ventral spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869]
comment: This term was added by GO_REF:0000021.
is_a: GO:0060850 ! regulation of transcription involved in cell fate commitment
intersection_of: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
intersection_of: part_of GO:0021521 ! ventral spinal cord interneuron specification
relationship: part_of GO:0021521 ! ventral spinal cord interneuron specification

[Term]
id: GO:0021914
name: negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling that is involved in the patterns of cell differentiation in the ventral spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb, PMID:11262869]
comment: This term was added by GO_REF:0000021.
synonym: "down regulation of smoothened signaling pathway in ventral spinal cord patterning" EXACT []
synonym: "down-regulation of smoothened signaling pathway in ventral spinal cord patterning" EXACT []
synonym: "downregulation of smoothened signaling pathway in ventral spinal cord patterning" EXACT []
synonym: "inhibition of smoothened signaling pathway in ventral spinal cord patterning" NARROW []
synonym: "negative regulation of hedgehog signaling pathway involved in ventral spinal cord patterning" EXACT [GOC:bf, GOC:ecd]
synonym: "negative regulation of hh signaling pathway involved in ventral spinal cord patterning" EXACT [GOC:bf, GOC:ecd]
synonym: "negative regulation of smoothened signalling pathway in ventral spinal cord patterning" EXACT []
is_a: GO:0045879 ! negative regulation of smoothened signaling pathway
is_a: GO:0051961 ! negative regulation of nervous system development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0021910 ! smoothened signaling pathway involved in ventral spinal cord patterning
relationship: negatively_regulates GO:0021910 ! smoothened signaling pathway involved in ventral spinal cord patterning
relationship: part_of GO:0021513 ! spinal cord dorsal/ventral patterning

[Term]
id: GO:0021915
name: neural tube development
namespace: biological_process
def: "The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0035295 ! tube development
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0060429 ! epithelium development
relationship: part_of GO:0007399 ! nervous system development
relationship: part_of GO:0043009 ! chordate embryonic development

[Term]
id: GO:0021916
name: inductive cell-cell signaling between paraxial mesoderm and motor neuron precursors
namespace: biological_process
def: "Short range signaling between cells of the paraxial mesoderm and motor neuron precursors in the spinal cord that specifies the fate of the motor column neuron precursors along the anterior-posterior axis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869]
comment: This term was added by GO_REF:0000021.
synonym: "inductive cell-cell signalling between paraxial mesoderm and motor neuron precursors" EXACT []
is_a: GO:0031129 ! inductive cell-cell signaling
relationship: part_of GO:0021917 ! somatic motor neuron fate commitment

[Term]
id: GO:0021917
name: somatic motor neuron fate commitment
namespace: biological_process
def: "The commitment of unspecified motor neurons to specific motor neuron cell along the anterior-posterior axis of the spinal cord and their capacity to differentiate into specific motor neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048663 ! neuron fate commitment
relationship: part_of GO:0021523 ! somatic motor neuron differentiation

[Term]
id: GO:0021918
name: regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of spinal cord motor neurons to specific motor neuron types along the anterior-posterior axis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869]
comment: This term was added by GO_REF:0000021.
is_a: GO:0060850 ! regulation of transcription involved in cell fate commitment
intersection_of: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
intersection_of: part_of GO:0021917 ! somatic motor neuron fate commitment
relationship: part_of GO:0021917 ! somatic motor neuron fate commitment

[Term]
id: GO:0021919
name: BMP signaling pathway involved in spinal cord dorsal/ventral patterning
namespace: biological_process
def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the spatial identity of regions along the dorsal-ventral axis of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12593981]
comment: This term was added by GO_REF:0000021.
synonym: "BMP signaling pathway in spinal cord dorsoventral patterning" EXACT [GOC:mah]
synonym: "BMP signaling pathway involved in spinal cord dorsal-ventral patterning" EXACT [GOC:mah]
synonym: "BMP signalling pathway involved in spinal cord dorsal-ventral patterning" EXACT []
synonym: "bone morphogenetic protein signaling pathway in spinal cord dorsal-ventral patterning" EXACT []
synonym: "bone morphogenetic protein signalling pathway involved in spinal cord dorsal-ventral patterning" EXACT []
is_a: GO:0030509 ! BMP signaling pathway
intersection_of: GO:0030509 ! BMP signaling pathway
intersection_of: part_of GO:0021513 ! spinal cord dorsal/ventral patterning
relationship: part_of GO:0021513 ! spinal cord dorsal/ventral patterning
relationship: part_of GO:0021914 ! negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning

[Term]
id: GO:0021920
name: regulation of transcription from RNA polymerase II promoter involved in spinal cord association neuron specification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of neuronal precursors to association neurons in the dorsal spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12593981]
comment: This term was added by GO_REF:0000021.
is_a: GO:0060850 ! regulation of transcription involved in cell fate commitment
intersection_of: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
intersection_of: part_of GO:0021519 ! spinal cord association neuron specification
relationship: part_of GO:0021519 ! spinal cord association neuron specification

[Term]
id: GO:0021921
name: regulation of cell proliferation in dorsal spinal cord
namespace: biological_process
def: "The process that modulates the frequency, rate or extent of cell proliferation in the dorsal spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:2000177 ! regulation of neural precursor cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010456 ! cell proliferation in dorsal spinal cord
relationship: part_of GO:0021516 ! dorsal spinal cord development
relationship: regulates GO:0010456 ! cell proliferation in dorsal spinal cord

[Term]
id: GO:0021922
name: Wnt signaling pathway involved in regulation of cell proliferation in dorsal spinal cord
namespace: biological_process
def: "The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of a cell in the dorsal spinal cord that affects the rate of its division." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12593981]
comment: This term was added by GO_REF:0000021.
synonym: "Wnt receptor signaling pathway involved in regulation of cell proliferation in dorsal spinal cord" EXACT []
synonym: "Wnt receptor signalling pathway involved in regulation of cell proliferation in dorsal spinal cord" EXACT []
synonym: "Wnt-activated signaling pathway involved in regulation of cell proliferation in dorsal spinal cord" EXACT [GOC:signaling]
is_a: GO:0016055 ! Wnt signaling pathway
intersection_of: GO:0016055 ! Wnt signaling pathway
intersection_of: part_of GO:0021921 ! regulation of cell proliferation in dorsal spinal cord
relationship: part_of GO:0021921 ! regulation of cell proliferation in dorsal spinal cord

[Term]
id: GO:0021923
name: cell proliferation in hindbrain ventricular zone
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population in the hindbrain region that is adjacent to the ventricular cavity." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12593981, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021534 ! cell proliferation in hindbrain

[Term]
id: GO:0021924
name: cell proliferation in external granule layer
namespace: biological_process
def: "The multiplication or reproduction of neuroblasts resulting in the expansion of a cell population in the external granule layer of the hindbrain. The external granule layer is the layer that originates from the rostral half of the rhombic lip in the first rhombomere." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021534 ! cell proliferation in hindbrain

[Term]
id: GO:0021925
name: cerebellar Purkinje cell precursor proliferation
namespace: biological_process
def: "The multiplication or reproduction of neuroblasts that will give rise to Purkinje cells. A Purkinje cell is an inhibitory GABAergic neuron found in the cerebellar cortex that projects to the deep cerebellar nuclei and brain stem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021923 ! cell proliferation in hindbrain ventricular zone

[Term]
id: GO:0021926
name: Golgi cell precursor proliferation
namespace: biological_process
def: "The multiplication or reproduction of neuroblasts that will give rise to Golgi cells. A Golgi cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021923 ! cell proliferation in hindbrain ventricular zone

[Term]
id: GO:0021927
name: deep nuclear neuron precursor proliferation
namespace: biological_process
def: "The multiplication or reproduction of neuroblasts that will give rise to deep nuclear neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021923 ! cell proliferation in hindbrain ventricular zone

[Term]
id: GO:0021928
name: basket cell precursor proliferation
namespace: biological_process
def: "The multiplication or reproduction of neuroblasts that will give rise to basket cells. A cerebellar basket cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021923 ! cell proliferation in hindbrain ventricular zone

[Term]
id: GO:0021929
name: stellate cell precursor proliferation
namespace: biological_process
def: "The multiplication or reproduction of neuroblasts that will give rise to stellate cells. A cerebellar stellate cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021923 ! cell proliferation in hindbrain ventricular zone

[Term]
id: GO:0021930
name: cerebellar granule cell precursor proliferation
namespace: biological_process
def: "The multiplication or reproduction of neuroblasts that will give rise to granule cells. A granule cell is a glutamatergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021924 ! cell proliferation in external granule layer

[Term]
id: GO:0021931
name: rostral hindbrain neuronal precursor cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of neuroblasts that will give rise to neurons of the lateral pontine nucleus and the locus ceruleus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021924 ! cell proliferation in external granule layer

[Term]
id: GO:0021932
name: hindbrain radial glia guided cell migration
namespace: biological_process
def: "The radially directed movement of a cell along radial glial cells in the hindbrain. Radial migration refers to a directed movement from the internal ventricular area to the outer surface of the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021535 ! cell migration in hindbrain

[Term]
id: GO:0021933
name: radial glia guided migration of cerebellar granule cell
namespace: biological_process
def: "The inward migration of postmitotic granule cells along a radial glial cell from the external granule layer to the internal granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021932 ! hindbrain radial glia guided cell migration

[Term]
id: GO:0021934
name: hindbrain tangential cell migration
namespace: biological_process
def: "The migration of a cell in the hindbrain in which cells move orthogonal to the direction of radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "hindbrain neurophilic migration" RELATED [PMID:15157725]
is_a: GO:0021535 ! cell migration in hindbrain

[Term]
id: GO:0021935
name: cerebellar granule cell precursor tangential migration
namespace: biological_process
def: "The early migration of granule cell precursors in which cells move orthogonal to the direction of radial migration and ultimately cover the superficial zone of the cerebellar primordium." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021934 ! hindbrain tangential cell migration

[Term]
id: GO:0021936
name: regulation of cerebellar granule cell precursor proliferation
namespace: biological_process
def: "The process that modulates the frequency, rate or extent of granule cell precursor proliferation." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0051960 ! regulation of nervous system development
is_a: GO:2000177 ! regulation of neural precursor cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0021930 ! cerebellar granule cell precursor proliferation
relationship: regulates GO:0021930 ! cerebellar granule cell precursor proliferation

[Term]
id: GO:0021937
name: cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation
namespace: biological_process
def: "The process that mediates the transfer of information from Purkinje cells to granule cell precursors resulting in an increase in rate of granule cell precursor cell proliferation." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
synonym: "Purkinje cell-granule cell precursor cell signalling involved in regulation of granule cell precursor cell proliferation" EXACT []
is_a: GO:0007267 ! cell-cell signaling
relationship: part_of GO:0021940 ! positive regulation of cerebellar granule cell precursor proliferation

[Term]
id: GO:0021938
name: smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
namespace: biological_process
def: "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened in cerebellar granule cells that contributes to the regulation of proliferation of the cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb, PMID:15157725]
comment: This term was added by GO_REF:0000021.
synonym: "hedgehog signaling pathway involved in regulation of granule cell precursor cell proliferation" EXACT [GOC:bf, GOC:ecd]
synonym: "hh signaling pathway involved in regulation of granule cell precursor cell proliferation" EXACT [GOC:bf, GOC:ecd]
synonym: "smoothened signalling pathway in regulation of granule cell precursor cell proliferation" EXACT []
is_a: GO:0007224 ! smoothened signaling pathway
is_a: GO:1905114 ! cell surface receptor signaling pathway involved in cell-cell signaling
relationship: part_of GO:0021937 ! cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation

[Term]
id: GO:0021939
name: extracellular matrix-granule cell signaling involved in regulation of granule cell precursor proliferation
namespace: biological_process
def: "The process that mediates the transfer of information from the extracellular matrix to granule cell precursors resulting in a decrease in rate of granule cell precursor cell proliferation." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
synonym: "extracellular matrix-granule cell signalling involved in regulation of granule cell precursor proliferation" EXACT []
is_a: GO:0035426 ! extracellular matrix-cell signaling
relationship: part_of GO:0021941 ! negative regulation of cerebellar granule cell precursor proliferation

[Term]
id: GO:0021940
name: positive regulation of cerebellar granule cell precursor proliferation
namespace: biological_process
def: "The process that activates or increases the rate or extent of granule cell precursor proliferation." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
synonym: "activation of granule cell precursor proliferation" NARROW []
synonym: "stimulation of granule cell precursor proliferation" NARROW []
synonym: "up regulation of granule cell precursor proliferation" EXACT []
synonym: "up-regulation of granule cell precursor proliferation" EXACT []
synonym: "upregulation of granule cell precursor proliferation" EXACT []
is_a: GO:0021936 ! regulation of cerebellar granule cell precursor proliferation
is_a: GO:0051962 ! positive regulation of nervous system development
is_a: GO:2000179 ! positive regulation of neural precursor cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0021930 ! cerebellar granule cell precursor proliferation
relationship: positively_regulates GO:0021930 ! cerebellar granule cell precursor proliferation

[Term]
id: GO:0021941
name: negative regulation of cerebellar granule cell precursor proliferation
namespace: biological_process
def: "The process that stops, prevents or reduces the rate or extent of granule cell precursor proliferation." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
synonym: "down regulation of granule cell precursor proliferation" EXACT []
synonym: "down-regulation of granule cell precursor proliferation" EXACT []
synonym: "downregulation of granule cell precursor proliferation" EXACT []
synonym: "inhibition of granule cell precursor proliferation" NARROW []
is_a: GO:0021936 ! regulation of cerebellar granule cell precursor proliferation
is_a: GO:0051961 ! negative regulation of nervous system development
is_a: GO:2000178 ! negative regulation of neural precursor cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0021930 ! cerebellar granule cell precursor proliferation
relationship: negatively_regulates GO:0021930 ! cerebellar granule cell precursor proliferation

[Term]
id: GO:0021942
name: radial glia guided migration of Purkinje cell
namespace: biological_process
def: "The migration of postmitotic a Purkinje cell along radial glial cells from the ventricular zone to the Purkinje cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021932 ! hindbrain radial glia guided cell migration

[Term]
id: GO:0021943
name: formation of radial glial scaffolds
namespace: biological_process
def: "The formation of scaffolds from a radial glial cell. The scaffolds are used as a substrate for the radial migration of cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
synonym: "Bergmann fiber biosynthesis" RELATED [PMID:15157725]
synonym: "Bergmann fiber formation" RELATED [PMID:15157725]
is_a: GO:0000904 ! cell morphogenesis involved in differentiation
relationship: part_of GO:0021932 ! hindbrain radial glia guided cell migration

[Term]
id: GO:0021944
name: neuronal-glial interaction involved in hindbrain glial-mediated radial cell migration
namespace: biological_process
def: "The changes in adhesion between a neuronal cell and a glial cell as a component of the process of hindbrain glial-mediated radial cell migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0016337 ! single organismal cell-cell adhesion
relationship: part_of GO:0021932 ! hindbrain radial glia guided cell migration

[Term]
id: GO:0021945
name: positive regulation of cerebellar granule cell migration by calcium
namespace: biological_process
def: "The process that increases the extent of granule cell motility using intracellular calcium signaling mechanisms during radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb, PMID:15157725]
comment: This term was added by GO_REF:0000021.
synonym: "calcium-mediated activation of granule cell migration" NARROW []
synonym: "calcium-mediated positive regulation of granule cell migration" EXACT [GOC:dph, GOC:tb]
synonym: "calcium-mediated stimulation of granule cell migration" NARROW []
synonym: "calcium-mediated up regulation of granule cell migration" EXACT []
synonym: "calcium-mediated up-regulation of granule cell migration" EXACT []
synonym: "calcium-mediated upregulation of granule cell migration" EXACT []
is_a: GO:0019722 ! calcium-mediated signaling
is_a: GO:0030335 ! positive regulation of cell migration
relationship: part_of GO:0021933 ! radial glia guided migration of cerebellar granule cell

[Term]
id: GO:0021946
name: deep nuclear neuron cell migration
namespace: biological_process
def: "The directed movement of a deep nuclear neuron from the ventricular zone to the deep hindbrain nuclei." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021535 ! cell migration in hindbrain

[Term]
id: GO:0021947
name: outward migration of deep nuclear neurons
namespace: biological_process
def: "The directed movement of a deep nuclear neuron from their ventrolateral origin to a rostrodorsal region of the cerebellar plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0001764 ! neuron migration
is_a: GO:0021535 ! cell migration in hindbrain
relationship: part_of GO:0021946 ! deep nuclear neuron cell migration

[Term]
id: GO:0021948
name: inward migration of deep nuclear neurons
namespace: biological_process
def: "The directed movement of a deep nuclear neuron from the rostrodorsal region of the cerebellar plate to their final more ventral position." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0001764 ! neuron migration
is_a: GO:0021535 ! cell migration in hindbrain
relationship: part_of GO:0021946 ! deep nuclear neuron cell migration

[Term]
id: GO:0021949
name: brainstem precerebellar neuron precursor migration
namespace: biological_process
def: "The early migration of a precerebellar neuronal precursor in which a cell move from the rhombic lip, orthogonal to the direction of radial migration and ultimately reside in the brainstem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021934 ! hindbrain tangential cell migration

[Term]
id: GO:0021950
name: chemorepulsion involved in precerebellar neuron migration
namespace: biological_process
def: "The creation and reception of signals that repel a precerebellar neuron as a component of the process of tangential migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
synonym: "negative chemotaxis involved in precerebellar neuron migration" EXACT [GOC:mah]
is_a: GO:0050919 ! negative chemotaxis
intersection_of: GO:0050919 ! negative chemotaxis
intersection_of: part_of GO:0021949 ! brainstem precerebellar neuron precursor migration
relationship: part_of GO:0021949 ! brainstem precerebellar neuron precursor migration

[Term]
id: GO:0021951
name: chemoattraction involved in precerebellar neuron migration
namespace: biological_process
def: "The creation and reception of signals that guide a precerebellar neuron towards their signals, where this process is involved in tangential migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
synonym: "positive chemotaxis involved in precerebellar neuron migration" EXACT [GOC:mah]
is_a: GO:0050918 ! positive chemotaxis
intersection_of: GO:0050918 ! positive chemotaxis
intersection_of: part_of GO:0021949 ! brainstem precerebellar neuron precursor migration
relationship: part_of GO:0021949 ! brainstem precerebellar neuron precursor migration

[Term]
id: GO:0021952
name: central nervous system projection neuron axonogenesis
namespace: biological_process
def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "central nervous system axon tract development" NARROW [GOC:dph]
is_a: GO:0021955 ! central nervous system neuron axonogenesis

[Term]
id: GO:0021953
name: central nervous system neuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0030182 ! neuron differentiation
relationship: part_of GO:0007417 ! central nervous system development

[Term]
id: GO:0021954
name: central nervous system neuron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048666 ! neuron development
relationship: part_of GO:0021953 ! central nervous system neuron differentiation

[Term]
id: GO:0021955
name: central nervous system neuron axonogenesis
namespace: biological_process
def: "Generation of a long process from a neuron whose cell body resides in the central nervous system. The process carries efferent (outgoing) action potentials from the cell body towards target cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0007409 ! axonogenesis
relationship: part_of GO:0021954 ! central nervous system neuron development

[Term]
id: GO:0021956
name: central nervous system interneuron axonogenesis
namespace: biological_process
def: "Generation of a long process that carries efferent (outgoing) action potentials from the cell body towards target cells from a neuron located in the central nervous system whose axons remain within a single brain region." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021955 ! central nervous system neuron axonogenesis

[Term]
id: GO:0021957
name: corticospinal tract morphogenesis
namespace: biological_process
def: "Generation of a long process of a pyramidal cell, that carries efferent (outgoing) action potentials from the cell body in cerebral cortex layer V towards target cells in the gray matter of the spinal cord. This axonal process is a member of those that make up the corticospinal tract." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:9878731]
comment: This term was added by GO_REF:0000021.
synonym: "corticospinal tract axonogenesis" EXACT [GOC:dph, PMID:9878731]
synonym: "CST axonogenesis" EXACT [GOC:dph, PMID:9878731]
is_a: GO:0021952 ! central nervous system projection neuron axonogenesis

[Term]
id: GO:0021958
name: gracilis tract morphogenesis
namespace: biological_process
def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the dorsal root ganglion towards target cells in the medulla. This axonal process is a member of those that make up the gracilis tract, a group of axons that are from neurons involved in proprioception from the lower trunk and lower limb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12867698]
comment: This term was added by GO_REF:0000021.
synonym: "tract of Goll morphogenesis" EXACT [PMID:12867698]
is_a: GO:0021952 ! central nervous system projection neuron axonogenesis

[Term]
id: GO:0021959
name: cuneatus tract morphogenesis
namespace: biological_process
def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the dorsal root ganglion towards target cells in the medulla. This axonal process is a member of those that make up the cuneatus tract, a group of axons that are from neurons involved in proprioception from the upper trunk and upper limb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12867698]
comment: This term was added by GO_REF:0000021.
synonym: "tract of Burdach morphogenesis" EXACT [PMID:12867698]
is_a: GO:0021952 ! central nervous system projection neuron axonogenesis

[Term]
id: GO:0021960
name: anterior commissure morphogenesis
namespace: biological_process
def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in one half of the cerebral cortex towards target cells in the contralateral half. This axonal process is a member of those that make up the anterior commissure, a small midline fiber tract that lies at the anterior end of the corpus callosum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021952 ! central nervous system projection neuron axonogenesis
relationship: part_of GO:0021537 ! telencephalon development

[Term]
id: GO:0021961
name: posterior commissure morphogenesis
namespace: biological_process
def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the midbrain towards target cells in the diencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021952 ! central nervous system projection neuron axonogenesis

[Term]
id: GO:0021962
name: vestibulospinal tract morphogenesis
namespace: biological_process
def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the vestibular nucleus of the pons towards target cells in the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021952 ! central nervous system projection neuron axonogenesis

[Term]
id: GO:0021963
name: spinothalamic tract morphogenesis
namespace: biological_process
def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the spinal cord towards target cells in the thalamus. This axonal process is a member of those that make up the spinothalamic tract, one of the major routes of nociceptive signaling." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "dorsolateral tract of Lissauer morphogenesis" EXACT []
is_a: GO:0021952 ! central nervous system projection neuron axonogenesis

[Term]
id: GO:0021964
name: rubrospinal tract morphogenesis
namespace: biological_process
def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the red nucleus of the midbrain towards target cells in the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021952 ! central nervous system projection neuron axonogenesis

[Term]
id: GO:0021965
name: spinal cord ventral commissure morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the spinal cord ventral commissure are generated and organized." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021952 ! central nervous system projection neuron axonogenesis
relationship: part_of GO:0021510 ! spinal cord development

[Term]
id: GO:0021966
name: corticospinal neuron axon guidance
namespace: biological_process
def: "The process in which the migration of an axon growth cone of a neuron that is part of the corticospinal tract is directed from the cerebral cortex layer V to the spinal cord dorsal funiculus in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:9878731]
comment: This term was added by GO_REF:0000021.
synonym: "corticospinal neuron axon pathfinding" EXACT [GOC:mah]
is_a: GO:0007411 ! axon guidance
relationship: part_of GO:0021957 ! corticospinal tract morphogenesis

[Term]
id: GO:0021967
name: corticospinal neuron axon guidance through the cerebral cortex
namespace: biological_process
def: "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed from its cell body in layer V through the cerebral cortex in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:9878731]
comment: This term was added by GO_REF:0000021.
synonym: "corticospinal neuron axon pathfinding through the cerebral cortex" NARROW [GOC:mah]
is_a: GO:0007411 ! axon guidance
relationship: part_of GO:0021966 ! corticospinal neuron axon guidance

[Term]
id: GO:0021968
name: corticospinal neuron axon guidance through the internal capsule
namespace: biological_process
def: "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the cerebral cortex through the internal capsule in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:9878731]
comment: This term was added by GO_REF:0000021.
synonym: "corticospinal neuron axon pathfinding through the internal capsule" EXACT [GOC:mah]
is_a: GO:0007411 ! axon guidance
relationship: part_of GO:0021966 ! corticospinal neuron axon guidance

[Term]
id: GO:0021969
name: corticospinal neuron axon guidance through the cerebral peduncle
namespace: biological_process
def: "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the internal capsule through the cerebral peduncle in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:9878731]
comment: This term was added by GO_REF:0000021.
synonym: "corticospinal neuron axon pathfinding through the cerebral peduncle" EXACT [GOC:mah]
is_a: GO:0007411 ! axon guidance
relationship: part_of GO:0021966 ! corticospinal neuron axon guidance

[Term]
id: GO:0021970
name: corticospinal neuron axon guidance through the basilar pons
namespace: biological_process
def: "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the cerebral peduncle through the basilar pons in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:9878731]
comment: This term was added by GO_REF:0000021.
synonym: "corticospinal neuron axon pathfinding through the basilar pons" EXACT [GOC:mah]
is_a: GO:0007411 ! axon guidance
relationship: part_of GO:0021966 ! corticospinal neuron axon guidance

[Term]
id: GO:0021971
name: corticospinal neuron axon guidance through the medullary pyramid
namespace: biological_process
def: "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the basilar pons through the medullary pyramid in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:9878731]
comment: This term was added by GO_REF:0000021.
synonym: "corticospinal neuron axon pathfinding through the medullary pyramid" EXACT [GOC:mah]
is_a: GO:0007411 ! axon guidance
relationship: part_of GO:0021966 ! corticospinal neuron axon guidance

[Term]
id: GO:0021972
name: corticospinal neuron axon guidance through spinal cord
namespace: biological_process
def: "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after decussation through the spinal cord in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:9878731]
comment: This term was added by GO_REF:0000021.
synonym: "corticospinal neuron axon pathfinding through spinal cord" EXACT [GOC:mah]
is_a: GO:0007411 ! axon guidance
relationship: part_of GO:0021966 ! corticospinal neuron axon guidance

[Term]
id: GO:0021973
name: corticospinal neuron axon decussation
namespace: biological_process
def: "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed to cross the midline to the contralateral side." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:9878731]
comment: This term was added by GO_REF:0000021.
is_a: GO:0016199 ! axon midline choice point recognition
relationship: part_of GO:0021966 ! corticospinal neuron axon guidance

[Term]
id: GO:0021974
name: trigeminothalamic tract morphogenesis
namespace: biological_process
def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in spinal cord towards target cells in the thalamus. This axonal process is a member of those that make up the trigeminothalamic tract, one of the major routes of nociceptive and temperature signaling from the face." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021952 ! central nervous system projection neuron axonogenesis

[Term]
id: GO:0021975
name: pons reticulospinal tract morphogenesis
namespace: biological_process
def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the pons towards target cells in the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021952 ! central nervous system projection neuron axonogenesis

[Term]
id: GO:0021976
name: medulla reticulospinal tract morphogenesis
namespace: biological_process
def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the medulla towards target cells in the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021952 ! central nervous system projection neuron axonogenesis

[Term]
id: GO:0021977
name: tectospinal tract morphogenesis
namespace: biological_process
def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the superior colliculus of the midbrain towards target cells in the ventral spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021952 ! central nervous system projection neuron axonogenesis

[Term]
id: GO:0021978
name: telencephalon regionalization
namespace: biological_process
def: "The regionalization process that creates areas within the forebrain that will direct the behavior of cell migration in differentiation as the telencephalon develops." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mgi_curators, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0021537 ! telencephalon development
relationship: part_of GO:0021871 ! forebrain regionalization

[Term]
id: GO:0021979
name: hypothalamus cell differentiation
namespace: biological_process
def: "The differentiation of cells that will contribute to the structure and function of the hypothalamus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mgi_curators, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0021854 ! hypothalamus development

[Term]
id: GO:0021980
name: subpallium cell migration
namespace: biological_process
def: "The orderly movement of cells from one site to another in the subpallium." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0022029 ! telencephalon cell migration
relationship: part_of GO:0021544 ! subpallium development

[Term]
id: GO:0021981
name: subpallium radially oriented migration
namespace: biological_process
def: "The migration of cells in the developing subpallium in which cells move from the ventricular and/or subventricular zone toward the surface of the brain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021980 ! subpallium cell migration

[Term]
id: GO:0021982
name: pineal gland development
namespace: biological_process
def: "The progression of the pineal gland over time from its initial formation until its mature state. The pineal gland is an endocrine gland that secretes melatonin and is involved in circadian rhythms." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "epiphysis development" EXACT [GOC:dph]
is_a: GO:0048732 ! gland development
relationship: part_of GO:0021536 ! diencephalon development
relationship: part_of GO:0035270 ! endocrine system development

[Term]
id: GO:0021983
name: pituitary gland development
namespace: biological_process
def: "The progression of the pituitary gland over time from its initial formation until its mature state. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "hypophysis development" RELATED [GOC:dph]
is_a: GO:0048732 ! gland development
relationship: part_of GO:0021536 ! diencephalon development
relationship: part_of GO:0035270 ! endocrine system development

[Term]
id: GO:0021984
name: adenohypophysis development
namespace: biological_process
def: "The progression of the adenohypophysis over time from its initial formation until its mature state. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "adenophysis development" EXACT []
synonym: "anterior pituitary development" EXACT []
synonym: "anterior pituitary gland development" EXACT []
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021983 ! pituitary gland development

[Term]
id: GO:0021985
name: neurohypophysis development
namespace: biological_process
def: "The progression of the neurohypophysis over time from its initial formation until its mature state. The neurohypophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "neurophysis development" EXACT []
synonym: "posterior pituitary development" EXACT []
synonym: "posterior pituitary gland development" EXACT []
is_a: GO:0048732 ! gland development
relationship: part_of GO:0021983 ! pituitary gland development

[Term]
id: GO:0021986
name: habenula development
namespace: biological_process
def: "The progression of the habenula over time from its initial formation until its mature state. The habenula is the group of nuclei that makes up the stalk of the pineal gland." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:9780721601465]
comment: This term was added by GO_REF:0000021.
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021538 ! epithalamus development

[Term]
id: GO:0021987
name: cerebral cortex development
namespace: biological_process
def: "The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "corticogenesis" NARROW [GOC:bf, PMID:25904839]
synonym: "neocortex development" RELATED [GOC:dph]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021543 ! pallium development

[Term]
id: GO:0021988
name: olfactory lobe development
namespace: biological_process
def: "The progression of the olfactory lobe over time from its initial formation until its mature state. The olfactory lobe is the area of the brain that process the neural inputs for the sense of smell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021537 ! telencephalon development

[Term]
id: GO:0021989
name: olfactory cortex development
namespace: biological_process
def: "The progression of the olfactory cortex over time from its initial formation until its mature state. The olfactory cortex is involved in the perception of smell. It receives input from the olfactory bulb and is responsible for the identification of odors." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021988 ! olfactory lobe development

[Term]
id: GO:0021990
name: neural plate formation
namespace: biological_process
def: "The formation of the flat, thickened layer of ectodermal cells known as the neural plate. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878932437, ISBN:0878932585, PMID:15806586]
comment: This term was added by GO_REF:0000021.
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0001839 ! neural plate morphogenesis

[Term]
id: GO:0021991
name: neural plate thickening
namespace: biological_process
def: "The process of apical-basal elongation of individual ectodermal cells during the formation of the neural placode." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15806586]
comment: This term was added by GO_REF:0000021.
is_a: GO:0002011 ! morphogenesis of an epithelial sheet
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0001839 ! neural plate morphogenesis

[Term]
id: GO:0021992
name: cell proliferation involved in neural plate elongation
namespace: biological_process
def: "The process of expansion of cell numbers in the neural plate due to cell division of progenitor cells preferentially in the rostrocaudal direction, resulting in the elongation of the tissue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15806586]
comment: This term was added by GO_REF:0000021.
is_a: GO:0061351 ! neural precursor cell proliferation
intersection_of: GO:0008283 ! cell proliferation
intersection_of: part_of GO:0014022 ! neural plate elongation
relationship: part_of GO:0014022 ! neural plate elongation

[Term]
id: GO:0021993
name: initiation of neural tube closure
namespace: biological_process
def: "The process in which closure points are established at multiple points and along the neural rostrocaudal axis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0002009 ! morphogenesis of an epithelium
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0001843 ! neural tube closure

[Term]
id: GO:0021994
name: progression of neural tube closure
namespace: biological_process
def: "The process in which the neural folds are fused extending from the initial closure points." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
relationship: part_of GO:0001843 ! neural tube closure

[Term]
id: GO:0021995
name: neuropore closure
namespace: biological_process
def: "The process of joining together the neural folds at either end of the neural tube." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
relationship: part_of GO:0001843 ! neural tube closure

[Term]
id: GO:0021996
name: lamina terminalis formation
namespace: biological_process
def: "The process in which the anterior-most portion of the neural axis is formed by closure of the anterior neuropore." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021506 ! anterior neuropore closure

[Term]
id: GO:0021997
name: neural plate axis specification
namespace: biological_process
def: "The pattern specification process in which the axes of the nervous system are established." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "neural plate axis determination" RELATED [GOC:dph]
is_a: GO:0000578 ! embryonic axis specification
relationship: part_of GO:0001840 ! neural plate development
relationship: part_of GO:0060896 ! neural plate pattern specification

[Term]
id: GO:0021998
name: neural plate mediolateral regionalization
namespace: biological_process
def: "The process that regulates the coordinated growth and differentiation that establishes the non-random mediolateral spatial arrangement of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "neural plate mediolateral pattern formation" RELATED [GOC:dph]
is_a: GO:0060897 ! neural plate regionalization

[Term]
id: GO:0021999
name: neural plate anterior/posterior regionalization
namespace: biological_process
def: "The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "neural plate anterior/posterior pattern formation" RELATED [GOC:dph]
is_a: GO:0009952 ! anterior/posterior pattern specification
is_a: GO:0060897 ! neural plate regionalization

[Term]
id: GO:0022000
name: forebrain induction by the anterior neural ridge
namespace: biological_process
def: "The close range interaction of the anterior neural ridge to the caudal region of the neural plate that specifies the forebrain fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0031128 ! developmental induction
relationship: part_of GO:0021999 ! neural plate anterior/posterior regionalization

[Term]
id: GO:0022001
name: negative regulation of anterior neural cell fate commitment of the neural plate
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency or rate at which a cell adopts an anterior neural cell fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb]
comment: This term was added by GO_REF:0000021.
synonym: "caudalization of neural plate" EXACT []
synonym: "down regulation of anterior neural cell fate of the neural plate" EXACT []
synonym: "down-regulation of anterior neural cell fate of the neural plate" EXACT []
synonym: "downregulation of anterior neural cell fate of the neural plate" EXACT []
synonym: "inhibition of anterior neural cell fate of the neural plate" NARROW []
synonym: "negative regulation of anterior neural cell fate of the neural plate" EXACT [GOC:dph, GOC:tb]
synonym: "posteriorization" BROAD []
is_a: GO:0010454 ! negative regulation of cell fate commitment
is_a: GO:0051961 ! negative regulation of nervous system development
relationship: part_of GO:0021999 ! neural plate anterior/posterior regionalization

[Term]
id: GO:0022002
name: negative regulation of anterior neural cell fate commitment of the neural plate by Wnt signaling pathway
namespace: biological_process
def: "The series of molecular signals that stops, prevents or reduces the frequency or rate at which a cell adopts an anterior neural cell fate, initiated by binding of Wnt protein to a receptor on the surface of the target cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb]
comment: This term was added by GO_REF:0000021.
synonym: "negative regulation of anterior neural cell fate commitment of the neural plate by Wnt receptor signaling pathway" EXACT []
synonym: "negative regulation of anterior neural cell fate commitment of the neural plate by Wnt-activated signaling pathway" EXACT [GOC:signaling]
synonym: "Wnt receptor signaling involved in down regulation of anterior neural cell fate of the neural plate" EXACT []
synonym: "Wnt receptor signaling involved in down-regulation of anterior neural cell fate of the neural plate" EXACT []
synonym: "Wnt receptor signaling involved in downregulation of anterior neural cell fate of the neural plate" EXACT []
synonym: "Wnt receptor signaling involved in inhibition of anterior neural cell fate of the neural plate" NARROW []
synonym: "Wnt receptor signaling involved in negative regulation of anterior neural cell fate of the neural plate" EXACT [GOC:dph, GOC:tb]
synonym: "Wnt receptor signalling involved in negative regulation of anterior neural cell fate of the neural plate" EXACT []
is_a: GO:0016055 ! Wnt signaling pathway
is_a: GO:0022001 ! negative regulation of anterior neural cell fate commitment of the neural plate

[Term]
id: GO:0022003
name: negative regulation of anterior neural cell fate commitment of the neural plate by fibroblast growth factor receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals that stops, prevents or reduces the frequency or rate at which cell adopts an anterior neural cell fate, generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb]
comment: This term was added by GO_REF:0000021.
synonym: "fgf receptor signaling involved in down regulation of anterior neural cell fate of the neural plate" EXACT []
synonym: "fgf receptor signaling involved in down-regulation of anterior neural cell fate of the neural plate" EXACT []
synonym: "fgf receptor signaling involved in downregulation of anterior neural cell fate of the neural plate" EXACT []
synonym: "fgf receptor signaling involved in inhibition of anterior neural cell fate of the neural plate" NARROW []
synonym: "fgf receptor signaling involved in negative regulation of anterior neural cell fate of the neural plate" EXACT [GOC:dph, GOC:tb]
synonym: "fgf receptor signalling involved in negative regulation of anterior neural cell fate of the neural plate" EXACT []
is_a: GO:0022001 ! negative regulation of anterior neural cell fate commitment of the neural plate
is_a: GO:0060825 ! fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation

[Term]
id: GO:0022004
name: midbrain-hindbrain boundary maturation during brain development
namespace: biological_process
def: "A developmental process occurring after the brain has been specified along the neural axis that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15541513]
comment: This term was added by GO_REF:0000021.
is_a: GO:0044707 ! single-multicellular organism process
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0021732 ! midbrain-hindbrain boundary maturation

[Term]
id: GO:0022005
name: midbrain-hindbrain boundary maturation during neural plate development
namespace: biological_process
def: "A developmental process occurring before the brain has been specified along the neural axis that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15541513]
comment: This term was added by GO_REF:0000021.
synonym: "midbrain-hindbrain boundary maturation involved in neural plate development" RELATED [GOC:dph, GOC:tb]
is_a: GO:0044707 ! single-multicellular organism process
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0021732 ! midbrain-hindbrain boundary maturation

[Term]
id: GO:0022006
name: zona limitans intrathalamica formation
namespace: biological_process
def: "The formation of the narrow stripe of cells that lies between the prospective dorsal and ventral thalami. This boundary contains signals that pattern the prethalamic and thalamic territories of the future mid-diencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11425897, PMID:16452095]
comment: This term was added by GO_REF:0000021.
synonym: "zli biosynthesis" EXACT []
synonym: "zli formation" EXACT []
is_a: GO:0048859 ! formation of anatomical boundary
relationship: part_of GO:0021903 ! rostrocaudal neural tube patterning

[Term]
id: GO:0022007
name: convergent extension involved in neural plate elongation
namespace: biological_process
def: "The process of directed cell movement in the neural plate resulting in tissue elongation via intercalation of adjacent cells in an epithelial sheet at the midline, leading to narrowing and lengthening of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:13679871, PMID:15806586]
comment: This term was added by GO_REF:0000021.
is_a: GO:0060027 ! convergent extension involved in gastrulation
is_a: GO:0060029 ! convergent extension involved in organogenesis
intersection_of: GO:0060026 ! convergent extension
intersection_of: part_of GO:0014022 ! neural plate elongation
relationship: part_of GO:0014022 ! neural plate elongation

[Term]
id: GO:0022008
name: neurogenesis
namespace: biological_process
def: "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "nervous system cell generation" EXACT systematic_synonym []
synonym: "neural cell differentiation" RELATED [GOC:BHF, GOC:dph]
xref: Wikipedia:Neurogenesis
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0007399 ! nervous system development

[Term]
id: GO:0022009
name: central nervous system vasculogenesis
namespace: biological_process
def: "The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes in the central nervous system. The capillary endothelial cells in the brain are specialized to form the blood-brain barrier." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0001570 ! vasculogenesis
relationship: part_of GO:0014045 ! establishment of endothelial blood-brain barrier

[Term]
id: GO:0022010
name: central nervous system myelination
namespace: biological_process
def: "The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of oligodendrocytes in the central nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "myelination in central nervous system" EXACT []
is_a: GO:0032291 ! axon ensheathment in central nervous system
is_a: GO:0042552 ! myelination
relationship: part_of GO:0014003 ! oligodendrocyte development

[Term]
id: GO:0022011
name: myelination in peripheral nervous system
namespace: biological_process
def: "The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of Schwann cells in the peripheral nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "peripheral nervous system myelination" EXACT []
is_a: GO:0032292 ! peripheral nervous system axon ensheathment
is_a: GO:0042552 ! myelination
relationship: part_of GO:0014044 ! Schwann cell development

[Term]
id: GO:0022012
name: subpallium cell proliferation in forebrain
namespace: biological_process
def: "The multiplication or reproduction of subpallium cells in the forebrain, resulting in the expansion of a cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021846 ! cell proliferation in forebrain
relationship: part_of GO:0021544 ! subpallium development

[Term]
id: GO:0022013
name: pallium cell proliferation in forebrain
namespace: biological_process
def: "The multiplication or reproduction of pallium cells in the forebrain, resulting in the expansion of the cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021846 ! cell proliferation in forebrain
relationship: part_of GO:0021543 ! pallium development

[Term]
id: GO:0022014
name: radial glial cell division in subpallium
namespace: biological_process
def: "The division of a radial glial cell in the subpallium. A radial glial cell is a precursor cell that gives rise to neurons and astrocytes." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021864 ! radial glial cell division in forebrain
relationship: part_of GO:0022012 ! subpallium cell proliferation in forebrain

[Term]
id: GO:0022015
name: radial glial cell division in pallium
namespace: biological_process
def: "The division of a radial glial cell in the pallium. A radial glial cell is a precursor cell that gives rise to neurons and astrocytes." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0051301 ! cell division
relationship: part_of GO:0022013 ! pallium cell proliferation in forebrain

[Term]
id: GO:0022016
name: pallium glioblast division
namespace: biological_process
def: "The division of a glioblast in the pallium. A glioblast is a dividing precursor cell that gives rise to glial cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "glioblast cell division in pallium" EXACT [GOC:curators]
is_a: GO:0048860 ! glioblast division
relationship: part_of GO:0022013 ! pallium cell proliferation in forebrain

[Term]
id: GO:0022017
name: neuroblast division in pallium
namespace: biological_process
def: "The division of neuroblasts in the pallium. Neuroblasts are precursor cells that give rise to neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021873 ! forebrain neuroblast division
relationship: part_of GO:0022013 ! pallium cell proliferation in forebrain

[Term]
id: GO:0022018
name: lateral ganglionic eminence cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of lateral ganglionic eminence cells, resulting in the expansion of the cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0022012 ! subpallium cell proliferation in forebrain

[Term]
id: GO:0022019
name: dorsal lateral ganglionic eminence cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of dorsal lateral ganglionic eminence cells, resulting in the expansion of the cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0022012 ! subpallium cell proliferation in forebrain
relationship: part_of GO:0022018 ! lateral ganglionic eminence cell proliferation

[Term]
id: GO:0022020
name: medial ganglionic eminence cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of medial ganglionic eminence cells, resulting in the expansion of a cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0022012 ! subpallium cell proliferation in forebrain

[Term]
id: GO:0022021
name: caudal ganglionic eminence cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of caudal ganglionic eminence cells, resulting in the expansion of a cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0022012 ! subpallium cell proliferation in forebrain

[Term]
id: GO:0022022
name: septal cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of septal cells, resulting in the expansion of a cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "septum cell proliferation" EXACT []
is_a: GO:0022012 ! subpallium cell proliferation in forebrain

[Term]
id: GO:0022023
name: radial glial cell fate commitment in forebrain
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a radial glial cell in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021781 ! glial cell fate commitment
is_a: GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain
relationship: part_of GO:0021861 ! forebrain radial glial cell differentiation

[Term]
id: GO:0022024
name: BMP signaling pathway involved in forebrain neuron fate commitment
namespace: biological_process
def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "BMP signalling pathway involved in forebrain neuron fate commitment" EXACT []
synonym: "bone morphogenetic protein signaling pathway involved in forebrain neuron fate commitment" EXACT []
synonym: "bone morphogenetic protein signalling pathway involved in forebrain neuron fate commitment" EXACT []
is_a: GO:0021882 ! regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment
is_a: GO:0030509 ! BMP signaling pathway
intersection_of: GO:0030509 ! BMP signaling pathway
intersection_of: part_of GO:0021877 ! forebrain neuron fate commitment
relationship: part_of GO:0021877 ! forebrain neuron fate commitment
relationship: part_of GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain

[Term]
id: GO:0022025
name: leukemia inhibitory factor signaling pathway involved in forebrain neuron fate commitment
namespace: biological_process
def: "Any series of molecular signals initiated by the binding of leukemia inhibitory factor to a receptor on the surface of the target cell, that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:signaling]
comment: This term was added by GO_REF:0000021.
synonym: "leukemia inhibitory factor signalling pathway involved in forebrain neuron fate commitment" EXACT []
is_a: GO:0048861 ! leukemia inhibitory factor signaling pathway
intersection_of: GO:0048861 ! leukemia inhibitory factor signaling pathway
intersection_of: part_of GO:0021877 ! forebrain neuron fate commitment
relationship: part_of GO:0021877 ! forebrain neuron fate commitment
relationship: part_of GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain

[Term]
id: GO:0022026
name: epidermal growth factor signaling pathway involved in forebrain neuron fate commitment
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a epidermal growth factor receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "epidermal growth factor signalling pathway involved in forebrain neuron fate commitment" EXACT []
is_a: GO:0007173 ! epidermal growth factor receptor signaling pathway
intersection_of: GO:0007173 ! epidermal growth factor receptor signaling pathway
intersection_of: part_of GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain
relationship: part_of GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain

[Term]
id: GO:0022027
name: interkinetic nuclear migration
namespace: biological_process
def: "The movement of the nucleus of the ventricular zone cell between the apical and the basal zone surfaces. Mitosis occurs when the nucleus is near the apical surface, that is, the lumen of the ventricle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0051647 ! nucleus localization
relationship: part_of GO:0021846 ! cell proliferation in forebrain

[Term]
id: GO:0022028
name: tangential migration from the subventricular zone to the olfactory bulb
namespace: biological_process
def: "The migration of cells in the telencephalon from the subventricular zone to the olfactory bulb in which cells move orthogonally to the direction of radial migration and do not use radial glial cell processes as substrates for migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "rostral migratory stream migration" EXACT []
is_a: GO:0022029 ! telencephalon cell migration
relationship: part_of GO:0021772 ! olfactory bulb development

[Term]
id: GO:0022029
name: telencephalon cell migration
namespace: biological_process
def: "The orderly movement of a cell from one site to another at least one of which is located in the telencephalon." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021885 ! forebrain cell migration
relationship: part_of GO:0021537 ! telencephalon development

[Term]
id: GO:0022030
name: telencephalon glial cell migration
namespace: biological_process
def: "The orderly movement of glial cells through the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0008347 ! glial cell migration
is_a: GO:0022029 ! telencephalon cell migration

[Term]
id: GO:0022031
name: telencephalon astrocyte cell migration
namespace: biological_process
def: "The orderly movement of an astrocyte cell through the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0022030 ! telencephalon glial cell migration
is_a: GO:0043615 ! astrocyte cell migration

[Term]
id: GO:0022032
name: telencephalon oligodendrocyte cell migration
namespace: biological_process
def: "The multiplication or reproduction of telencephalon oligodendrocyte cells, resulting in the expansion of a cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0022030 ! telencephalon glial cell migration

[Term]
id: GO:0022033
name: telencephalon microglial cell migration
namespace: biological_process
def: "The orderly movement of microglial cells through the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0022030 ! telencephalon glial cell migration

[Term]
id: GO:0022034
name: rhombomere cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of rhombomere cells, resulting in the expansion of the cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0061351 ! neural precursor cell proliferation
relationship: part_of GO:0021546 ! rhombomere development

[Term]
id: GO:0022035
name: rhombomere cell migration
namespace: biological_process
def: "The movement of a cell within a rhombomere. This process is known to occur as an early step in the generation of anatomical structure from a rhombomere." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15629700]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021535 ! cell migration in hindbrain
relationship: part_of GO:0021546 ! rhombomere development

[Term]
id: GO:0022036
name: rhombomere cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a rhombomere cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0021546 ! rhombomere development

[Term]
id: GO:0022037
name: metencephalon development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metencephalon over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0030902 ! hindbrain development

[Term]
id: GO:0022038
name: corpus callosum development
namespace: biological_process
def: "The process whose specific outcome is the progression of the corpus callosum over time, from its formation to the mature structure. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provide communication between the right and left cerebral hemispheres." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021537 ! telencephalon development

[Term]
id: GO:0022400
name: regulation of rhodopsin mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of rhodopsin-mediated signaling." [GOC:mah]
synonym: "regulation of rhodopsin mediated signalling" EXACT []
is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:0032101 ! regulation of response to external stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016056 ! rhodopsin mediated signaling pathway
relationship: regulates GO:0016056 ! rhodopsin mediated signaling pathway

[Term]
id: GO:0022401
name: negative adaptation of signaling pathway
namespace: biological_process
def: "The negative regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus." [GOC:isa_complete]
synonym: "negative adaptation of signal transduction pathway" EXACT []
synonym: "negative adaptation of signalling pathway" EXACT [GOC:mah]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0023058 ! adaptation of signaling pathway

[Term]
id: GO:0022402
name: cell cycle process
namespace: biological_process
def: "The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle]
subset: gocheck_do_not_manually_annotate
subset: gosubset_prok
is_a: GO:0044763 ! single-organism cellular process
intersection_of: GO:0009987 ! cellular process
intersection_of: part_of GO:0007049 ! cell cycle
relationship: part_of GO:0007049 ! cell cycle

[Term]
id: GO:0022403
name: cell cycle phase
namespace: biological_process
def: "One of the distinct periods or stages into which the cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events." [GOC:mtg_cell_cycle]
subset: gocheck_do_not_annotate
is_a: GO:0044848 ! biological phase

[Term]
id: GO:0022404
name: molting cycle process
namespace: biological_process
def: "A multicellular organismal process involved in the periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin." [GOC:isa_complete]
is_a: GO:0044707 ! single-multicellular organism process
relationship: part_of GO:0042303 ! molting cycle

[Term]
id: GO:0022405
name: hair cycle process
namespace: biological_process
def: "A multicellular organismal process involved in the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body." [GOC:isa_complete]
is_a: GO:0022404 ! molting cycle process
relationship: part_of GO:0042633 ! hair cycle

[Term]
id: GO:0022406
name: membrane docking
namespace: biological_process
def: "The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere." [GOC:isa_complete]
subset: goslim_pir
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0022407
name: regulation of cell-cell adhesion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell." [GOC:isa_complete]
is_a: GO:0030155 ! regulation of cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016337 ! single organismal cell-cell adhesion
relationship: regulates GO:0016337 ! single organismal cell-cell adhesion

[Term]
id: GO:0022408
name: negative regulation of cell-cell adhesion
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell." [GOC:isa_complete]
synonym: "down regulation of cell-cell adhesion" EXACT []
synonym: "down-regulation of cell-cell adhesion" EXACT []
synonym: "downregulation of cell-cell adhesion" EXACT []
synonym: "inhibition of cell-cell adhesion" NARROW []
is_a: GO:0007162 ! negative regulation of cell adhesion
is_a: GO:0022407 ! regulation of cell-cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016337 ! single organismal cell-cell adhesion
relationship: negatively_regulates GO:0016337 ! single organismal cell-cell adhesion

[Term]
id: GO:0022409
name: positive regulation of cell-cell adhesion
namespace: biological_process
def: "Any process that activates or increases the rate or extent of cell adhesion to another cell." [GOC:isa_complete]
synonym: "activation of cell-cell adhesion" NARROW []
synonym: "stimulation of cell-cell adhesion" NARROW []
synonym: "up regulation of cell-cell adhesion" EXACT []
synonym: "up-regulation of cell-cell adhesion" EXACT []
synonym: "upregulation of cell-cell adhesion" EXACT []
is_a: GO:0022407 ! regulation of cell-cell adhesion
is_a: GO:0045785 ! positive regulation of cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016337 ! single organismal cell-cell adhesion
relationship: positively_regulates GO:0016337 ! single organismal cell-cell adhesion

[Term]
id: GO:0022410
name: circadian sleep/wake cycle process
namespace: biological_process
def: "A behavioral process involved in the cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm." [GOC:isa_complete]
is_a: GO:0048512 ! circadian behavior
relationship: part_of GO:0042745 ! circadian sleep/wake cycle

[Term]
id: GO:0022411
name: cellular component disassembly
namespace: biological_process
alt_id: GO:0071845
def: "A cellular process that results in the breakdown of a cellular component." [GOC:isa_complete]
subset: goslim_pir
subset: gosubset_prok
synonym: "cell structure disassembly" EXACT []
synonym: "cellular component disassembly at cellular level" EXACT []
is_a: GO:0016043 ! cellular component organization
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0022412
name: cellular process involved in reproduction in multicellular organism
namespace: biological_process
def: "A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism." [GOC:isa_complete]
synonym: "reproductive cellular process in multicellular organism" EXACT [GOC:curators]
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0044763 ! single-organism cellular process
intersection_of: GO:0044763 ! single-organism cellular process
intersection_of: part_of GO:0032504 ! multicellular organism reproduction
relationship: part_of GO:0032504 ! multicellular organism reproduction

[Term]
id: GO:0022413
name: reproductive process in single-celled organism
namespace: biological_process
def: "A process, occurring at the cellular level, that is involved in the reproductive function of a single-celled organism." [GOC:isa_complete]
subset: gosubset_prok
is_a: GO:0022414 ! reproductive process
relationship: part_of GO:0032505 ! reproduction of a single-celled organism

[Term]
id: GO:0022414
name: reproductive process
namespace: biological_process
def: "A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:dph, GOC:isa_complete]
subset: gosubset_prok
is_a: GO:0008150 ! biological_process
intersection_of: GO:0008150 ! biological_process
intersection_of: part_of GO:0000003 ! reproduction
disjoint_from: GO:0044848 ! biological phase
relationship: part_of GO:0000003 ! reproduction

[Term]
id: GO:0022416
name: chaeta development
namespace: biological_process
def: "The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete]
synonym: "bristle development" NARROW [GOC:bf, GOC:dos]
is_a: GO:0007423 ! sensory organ development

[Term]
id: GO:0022417
name: protein maturation by protein folding
namespace: biological_process
def: "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that results in the attainment of the full functional capacity of a protein." [GOC:isa_complete]
is_a: GO:0006457 ! protein folding
is_a: GO:0051604 ! protein maturation

[Term]
id: GO:0022600
name: digestive system process
namespace: biological_process
def: "A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, GOC:jid, GOC:mtg_cardio]
is_a: GO:0003008 ! system process
intersection_of: GO:0003008 ! system process
intersection_of: part_of GO:0007586 ! digestion
relationship: part_of GO:0007586 ! digestion

[Term]
id: GO:0022601
name: menstrual cycle phase
namespace: biological_process
def: "The progression of physiological phases, occurring in the endometrium during the menstrual cycle that recur at regular intervals during the reproductive years. The menstrual cycle is an ovulation cycle where the endometrium is shed if pregnancy does not occur." [GOC:dph, GOC:isa_complete, GOC:jid]
subset: gocheck_do_not_annotate
is_a: GO:0044848 ! biological phase

[Term]
id: GO:0022602
name: ovulation cycle process
namespace: biological_process
def: "A process involved in the sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years." [GOC:isa_complete]
synonym: "estrous cycle process" RELATED []
synonym: "menstrual cycle process" RELATED []
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0048511 ! rhythmic process
intersection_of: GO:0044699 ! single-organism process
intersection_of: part_of GO:0042698 ! ovulation cycle
relationship: part_of GO:0042698 ! ovulation cycle

[Term]
id: GO:0022603
name: regulation of anatomical structure morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of morphogenesis" EXACT []
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009653 ! anatomical structure morphogenesis
relationship: regulates GO:0009653 ! anatomical structure morphogenesis

[Term]
id: GO:0022604
name: regulation of cell morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized." [GOC:isa_complete]
subset: gosubset_prok
synonym: "negative regulation of cell shape and cell size" RELATED [GOC:dph, GOC:tb]
synonym: "positive regulation of cell shape and cell size" RELATED [GOC:dph, GOC:tb]
synonym: "regulation of cell shape and cell size" RELATED [GOC:dph, GOC:tb]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000902 ! cell morphogenesis
relationship: regulates GO:0000902 ! cell morphogenesis

[Term]
id: GO:0022605
name: oogenesis stage
namespace: biological_process
def: "A reproductive process that is a step in the formation and maturation of an ovum or female gamete from a primordial female germ cell." [GOC:isa_complete, GOC:mtg_sensu]
synonym: "oogenesis process" EXACT []
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0048609 ! multicellular organismal reproductive process
relationship: part_of GO:0048477 ! oogenesis

[Term]
id: GO:0022606
name: establishment of proximal/distal cell polarity
namespace: biological_process
def: "The specification and formation of the polarity of a cell along its proximal/distal axis." [GOC:isa_complete]
is_a: GO:0061162 ! establishment of monopolar cell polarity

[Term]
id: GO:0022607
name: cellular component assembly
namespace: biological_process
alt_id: GO:0071844
def: "The aggregation, arrangement and bonding together of a cellular component." [GOC:isa_complete]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_pir
subset: gosubset_prok
synonym: "cell structure assembly" EXACT []
synonym: "cellular component assembly at cellular level" EXACT []
is_a: GO:0016043 ! cellular component organization
relationship: part_of GO:0044085 ! cellular component biogenesis

[Term]
id: GO:0022608
name: multicellular organism adhesion
namespace: biological_process
def: "The attachment of a multicellular organism to a substrate or other organism." [GOC:isa_complete]
is_a: GO:0022610 ! biological adhesion
is_a: GO:0044707 ! single-multicellular organism process

[Term]
id: GO:0022609
name: multicellular organism adhesion to substrate
namespace: biological_process
def: "The attachment of a multicellular organism to a surface or material." [GOC:isa_complete]
is_a: GO:0022608 ! multicellular organism adhesion

[Term]
id: GO:0022610
name: biological adhesion
namespace: biological_process
def: "The attachment of a cell or organism to a substrate, another cell, or other organism. Biological adhesion includes intracellular attachment between membrane regions." [GOC:isa_complete]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0008150 ! biological_process
disjoint_from: GO:0044848 ! biological phase

[Term]
id: GO:0022611
name: dormancy process
namespace: biological_process
def: "A developmental process in which dormancy (sometimes called a dormant state) is induced, maintained or broken. Dormancy is a suspension of most physiological activity and growth that can be reactivated." [GOC:isa_complete, GOC:PO_curators, PO_REF:00009]
comment: In plants and animals, dormancy may be a response to environmental conditions such as seasonality or extreme heat, drought, or cold. In plants, dormancy may involve the formation of dormant buds, and may be preceded by the senescence of plant parts such as leaves in woody plants or most of the shoot system in herbaceous perennials. The exit from dormancy in vascular plants is marked by resumed growth of buds and/or growth of vascular cambium.
synonym: "multicellular organism dormancy process" NARROW []
synonym: "spore dormancy process" NARROW [GOC:PO_curators]
is_a: GO:0032502 ! developmental process

[Term]
id: GO:0022612
name: gland morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a gland are generated and organized." [GOC:isa_complete]
is_a: GO:0009887 ! organ morphogenesis
relationship: part_of GO:0048732 ! gland development

[Term]
id: GO:0022613
name: ribonucleoprotein complex biogenesis
namespace: biological_process
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex." [GOC:isa_complete, GOC:mah]
subset: gosubset_prok
synonym: "ribonucleoprotein complex biogenesis and assembly" EXACT [GOC:mah]
synonym: "RNA-protein complex biogenesis" EXACT [GOC:mah]
is_a: GO:0044085 ! cellular component biogenesis

[Term]
id: GO:0022614
name: membrane to membrane docking
namespace: biological_process
def: "The initial attachment of a membrane to a target membrane, mediated by proteins protruding from the two membranes. Docking requires only that the membranes come close enough for the proteins to interact and adhere." [GOC:isa_complete]
synonym: "membrane-membrane docking" EXACT []
is_a: GO:0022406 ! membrane docking

[Term]
id: GO:0022615
name: protein to membrane docking
namespace: biological_process
def: "The initial attachment of a protein to a target membrane, mediated by a proteins protruding from the target membrane. Docking requires only that the proteins come close enough to interact and adhere." [GOC:isa_complete]
synonym: "protein-membrane docking" EXACT []
is_a: GO:0022406 ! membrane docking

[Term]
id: GO:0022616
name: DNA strand elongation
namespace: biological_process
def: "The DNA metabolic process in which a DNA strand is synthesized by adding nucleotides to the 3' end of an existing DNA stand." [GOC:isa_complete]
is_a: GO:0006259 ! DNA metabolic process

[Term]
id: GO:0022617
name: extracellular matrix disassembly
namespace: biological_process
def: "A process that results in the breakdown of the extracellular matrix." [GOC:jid]
is_a: GO:0022411 ! cellular component disassembly
is_a: GO:0030198 ! extracellular matrix organization

[Term]
id: GO:0022618
name: ribonucleoprotein complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex." [GOC:jl]
subset: goslim_chembl
subset: goslim_generic
subset: gosubset_prok
synonym: "protein-RNA complex assembly" EXACT []
synonym: "RNA-protein complex assembly" EXACT []
synonym: "RNP complex assembly" EXACT []
is_a: GO:0034622 ! cellular macromolecular complex assembly
is_a: GO:0071826 ! ribonucleoprotein complex subunit organization
relationship: part_of GO:0022613 ! ribonucleoprotein complex biogenesis

[Term]
id: GO:0022619
name: generative cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a generative cell. The generative cell gives rise to the sperm cells in the male gametophyte." [GOC:isa_complete]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0055046 ! microgametogenesis

[Term]
id: GO:0022620
name: vegetative cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a vegetative cell. The vegetative cell is gives rise to the pollen tube." [GOC:isa_complete]
synonym: "tube cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0055046 ! microgametogenesis

[Term]
id: GO:0022622
name: root system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the root system over time, from its formation to the mature structure." [GOC:isa_complete]
is_a: GO:0048731 ! system development

[Term]
id: GO:0022623
name: proteasome-activating nucleotidase complex
namespace: cellular_component
def: "A homohexameric complex that recognizes and unfolds core proteasome substrate proteins, and translocates them to the core complex in an ATP dependent manner." [GOC:bf, GOC:mtg_sensu, PMID:19363223, PMID:19481528]
synonym: "PAN" EXACT [PMID:19363223, PMID:19481528]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0022624 ! proteasome accessory complex

[Term]
id: GO:0022624
name: proteasome accessory complex
namespace: cellular_component
def: "A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex." [GOC:mtg_sensu]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0000502 ! proteasome complex

[Term]
id: GO:0022625
name: cytosolic large ribosomal subunit
namespace: cellular_component
alt_id: GO:0005842
alt_id: GO:0009282
alt_id: GO:0030498
alt_id: GO:0030872
def: "The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]
synonym: "50S ribosomal subunit" NARROW []
synonym: "60S ribosomal subunit" NARROW []
synonym: "eukaryotic ribosomal LSU" NARROW []
synonym: "prokaryotic large ribosomal subunit" NARROW []
is_a: GO:0015934 ! large ribosomal subunit
is_a: GO:0044445 ! cytosolic part
intersection_of: GO:0015934 ! large ribosomal subunit
intersection_of: part_of GO:0022626 ! cytosolic ribosome
relationship: part_of GO:0022626 ! cytosolic ribosome

[Term]
id: GO:0022626
name: cytosolic ribosome
namespace: cellular_component
alt_id: GO:0005830
alt_id: GO:0009281
alt_id: GO:0030871
def: "A ribosome located in the cytosol." [GOC:mtg_sensu]
synonym: "70S ribosome" NARROW []
synonym: "80S ribosome" NARROW []
is_a: GO:0005840 ! ribosome
is_a: GO:0044445 ! cytosolic part
intersection_of: GO:0005840 ! ribosome
intersection_of: part_of GO:0005829 ! cytosol
relationship: part_of GO:0005829 ! cytosol

[Term]
id: GO:0022627
name: cytosolic small ribosomal subunit
namespace: cellular_component
alt_id: GO:0005843
alt_id: GO:0009283
alt_id: GO:0030499
alt_id: GO:0030873
def: "The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]
synonym: "30S ribosomal subunit" NARROW []
synonym: "40S ribosomal subunit" NARROW []
synonym: "eukaryotic ribosomal SSU" NARROW []
synonym: "prokaryotic small ribosomal subunit" NARROW []
is_a: GO:0015935 ! small ribosomal subunit
is_a: GO:0044445 ! cytosolic part
intersection_of: GO:0015935 ! small ribosomal subunit
intersection_of: part_of GO:0022626 ! cytosolic ribosome
relationship: part_of GO:0022626 ! cytosolic ribosome

[Term]
id: GO:0022628
name: chloroplast large ribosomal subunit
namespace: cellular_component
def: "The large subunit of a ribosome contained within a chloroplast." [GOC:mtg_sensu]
synonym: "chloroplast ribosomal large subunit complex" EXACT []
synonym: "chloroplast ribosomal LSU complex" EXACT []
is_a: GO:0000311 ! plastid large ribosomal subunit
is_a: GO:0044434 ! chloroplast part
intersection_of: GO:0015934 ! large ribosomal subunit
intersection_of: part_of GO:0043253 ! chloroplast ribosome
relationship: part_of GO:0043253 ! chloroplast ribosome

[Term]
id: GO:0022629
name: chloroplast small ribosomal subunit
namespace: cellular_component
def: "The small subunit of a ribosome contained within a chloroplast." [GOC:mtg_sensu]
synonym: "chloroplast ribosomal small subunit complex" EXACT []
synonym: "chloroplast ribosomal SSU complex" EXACT []
is_a: GO:0000312 ! plastid small ribosomal subunit
is_a: GO:0044434 ! chloroplast part
intersection_of: GO:0015935 ! small ribosomal subunit
intersection_of: part_of GO:0043253 ! chloroplast ribosome
relationship: part_of GO:0043253 ! chloroplast ribosome

[Term]
id: GO:0022803
name: passive transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute from one side of the membrane to the other, down the solute's concentration gradient." [GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
xref: Reactome:REACT_118066 "Passive I- efflux mediated by SMCT1, Staphylococcus aureus N315"
xref: Reactome:REACT_118091 "Passive I- efflux mediated by SMCT1, Xenopus tropicalis"
xref: Reactome:REACT_118204 "Passive I- efflux mediated by SMCT1, Mus musculus"
xref: Reactome:REACT_118231 "Passive I- efflux mediated by SMCT1, Bos taurus"
xref: Reactome:REACT_118327 "Passive I- efflux mediated by SMCT1, Taeniopygia guttata"
xref: Reactome:REACT_118347 "Passive I- efflux mediated by SMCT1, Rattus norvegicus"
xref: Reactome:REACT_118350 "Passive I- efflux mediated by SMCT1, Canis familiaris"
xref: Reactome:REACT_118478 "Passive I- efflux mediated by SMCT1, Sus scrofa"
xref: Reactome:REACT_118490 "Passive I- efflux mediated by SMCT1, Gallus gallus"
xref: Reactome:REACT_118544 "Passive I- efflux mediated by SMCT1, Danio rerio"
xref: Reactome:REACT_19251 "Passive I- efflux mediated by SMCT1, Homo sapiens"
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0022804
name: active transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "active carrier activity" EXACT []
synonym: "carrier activity" EXACT []
synonym: "permease activity" EXACT []
synonym: "pump activity" EXACT []
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0022809
name: mobile ion carrier activity
namespace: molecular_function
def: "This is a type of carrier produced by bacteria. It enables passive transport by shielding the ion that is being transported from the lipid membrane. It carries an ion across the membrane by enclosing the ion and travelling across the membrane. It does not form a fully open pore across the membrane." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]
synonym: "ionophore" BROAD []
is_a: GO:0022803 ! passive transmembrane transporter activity
relationship: part_of GO:0006811 ! ion transport

[Term]
id: GO:0022810
name: membrane potential driven uniporter activity
namespace: molecular_function
def: "Enables the active transport of a solute across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged." [GOC:mtg_transport, ISBN:0815340729]
synonym: "porter" BROAD []
is_a: GO:0022814 ! facilitated diffusion

[Term]
id: GO:0022814
name: facilitated diffusion
namespace: molecular_function
def: "Catalysis of the transfer of a single solute from one side of the membrane to the other by a mechanism involving conformational change, either by facilitated diffusion or in a membrane potential dependent process if the solute is charged." [GOC:mtg_transport, ISBN:0815340729]
synonym: "porters" BROAD []
synonym: "uniporter activity z" EXACT []
xref: Wikipedia:Facilitated_diffusion
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0022815
name: obsolete large uncharged polar molecule transmembrane transporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the transfer of a large uncharged polar molecule from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
comment: This term was made obsolete because 'large uncharged polar molecule' is not a useful chemical grouping term.
synonym: "large uncharged polar molecule transmembrane transporter activity" EXACT []
is_obsolete: true
replaced_by: GO:0022891

[Term]
id: GO:0022818
name: sodium ion uniporter activity
namespace: molecular_function
def: "Catalysis of the active transport of a sodium ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015081 ! sodium ion transmembrane transporter activity
is_a: GO:0022810 ! membrane potential driven uniporter activity

[Term]
id: GO:0022819
name: potassium ion uniporter activity
namespace: molecular_function
def: "Catalysis of the active transport of a potassium ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015079 ! potassium ion transmembrane transporter activity
is_a: GO:0022810 ! membrane potential driven uniporter activity

[Term]
id: GO:0022820
name: potassium ion symporter activity
namespace: molecular_function
def: "Catalysis of the active transport of a potassium ion across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015079 ! potassium ion transmembrane transporter activity
is_a: GO:0015293 ! symporter activity

[Term]
id: GO:0022821
name: potassium ion antiporter activity
namespace: molecular_function
def: "Catalysis of the active transport of a potassium ion across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015079 ! potassium ion transmembrane transporter activity
is_a: GO:0015297 ! antiporter activity

[Term]
id: GO:0022824
name: transmitter-gated ion channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of an ion by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
synonym: "ionotropic neurotransmitter receptor activity" NARROW [GOC:bf, GOC:sart]
is_a: GO:0005230 ! extracellular ligand-gated ion channel activity
is_a: GO:0022835 ! transmitter-gated channel activity

[Term]
id: GO:0022825
name: obsolete copper-exporting ATPase activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it was a placeholder during work on transporter terms, and was not defined.
synonym: "copper-exporting ATPase activity" EXACT []
is_obsolete: true
replaced_by: GO:0043682

[Term]
id: GO:0022828
name: phosphorylation-gated channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a solute by a channel that opens in response to phosphorylation of one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0022836 ! gated channel activity

[Term]
id: GO:0022829
name: wide pore channel activity
namespace: molecular_function
def: "Enables the transport of a solute across a membrane via a large pore, un-gated channel. Examples include gap junctions, which transport substances from one cell to another; and porins which transport substances in and out of bacteria, mitochondria and chloroplasts." [GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "gap junction activity" NARROW []
synonym: "non-gated, wide pore channel activity" EXACT []
is_a: GO:0015267 ! channel activity

[Term]
id: GO:0022831
name: narrow pore, gated channel activity
namespace: molecular_function
def: "Enables the transport of a solute across a membrane via a narrow pore channel that opens in response to a particular stimulus." [GOC:mtg_transport, ISBN:0815340729]
synonym: "ion channels" RELATED []
xref: Wikipedia:Ion_channels
is_a: GO:0022842 ! narrow pore channel activity

[Term]
id: GO:0022832
name: voltage-gated channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a solute by a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0022836 ! gated channel activity
relationship: part_of GO:0051049 ! regulation of transport

[Term]
id: GO:0022833
name: mechanically gated channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a solute by a channel that opens in response to a mechanical stress." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0022836 ! gated channel activity

[Term]
id: GO:0022834
name: ligand-gated channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0022836 ! gated channel activity
is_a: GO:0099600 ! transmembrane receptor activity

[Term]
id: GO:0022835
name: transmitter-gated channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a solute by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
synonym: "extracellular substance gated channel activity" EXACT []
synonym: "neurotransmitter-gated channel activity" EXACT []
is_a: GO:0004888 ! transmembrane signaling receptor activity
is_a: GO:0022834 ! ligand-gated channel activity
is_a: GO:0030594 ! neurotransmitter receptor activity

[Term]
id: GO:0022836
name: gated channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a solute by a channel that opens in response to a specific stimulus." [GOC:mtg_transport]
is_a: GO:0015267 ! channel activity

[Term]
id: GO:0022838
name: substrate-specific channel activity
namespace: molecular_function
def: "Enables the energy-independent facilitated diffusion, mediated by passage of a specific solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules." [GOC:mtg_transport]
is_a: GO:0015267 ! channel activity
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity

[Term]
id: GO:0022839
name: ion gated channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a solute by a channel that opens in response to a specific ion stimulus." [GOC:mtg_transport]
is_a: GO:0022836 ! gated channel activity

[Term]
id: GO:0022840
name: leak channel activity
namespace: molecular_function
def: "Enables the transport of a solute across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0022842 ! narrow pore channel activity

[Term]
id: GO:0022841
name: potassium ion leak channel activity
namespace: molecular_function
def: "Enables the transport of a potassium ion across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0005267 ! potassium channel activity
is_a: GO:0022840 ! leak channel activity

[Term]
id: GO:0022842
name: narrow pore channel activity
namespace: molecular_function
def: "Enables the transport of a solute across a membrane via a narrow pore channel that may be gated or ungated." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015267 ! channel activity

[Term]
id: GO:0022843
name: voltage-gated cation channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0005244 ! voltage-gated ion channel activity
is_a: GO:0005261 ! cation channel activity

[Term]
id: GO:0022848
name: acetylcholine-gated cation channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a cation by a channel that opens when acetylcholine has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015464 ! acetylcholine receptor activity
is_a: GO:0022824 ! transmitter-gated ion channel activity

[Term]
id: GO:0022849
name: glutamate-gated calcium ion channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a calcium ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0004970 ! ionotropic glutamate receptor activity
is_a: GO:0099604 ! ligand-gated calcium channel activity

[Term]
id: GO:0022850
name: serotonin-gated cation channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a cation by a channel that opens when serotonin has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0022824 ! transmitter-gated ion channel activity
is_a: GO:0099589 ! serotonin receptor activity

[Term]
id: GO:0022851
name: GABA-gated chloride ion channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a chloride ion by a channel that opens when GABA has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0005254 ! chloride channel activity
is_a: GO:0016917 ! GABA receptor activity
is_a: GO:0022824 ! transmitter-gated ion channel activity

[Term]
id: GO:0022852
name: glycine-gated chloride ion channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a chloride ion by a channel that opens when glycine has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0005254 ! chloride channel activity
is_a: GO:0022824 ! transmitter-gated ion channel activity

[Term]
id: GO:0022853
name: active ion transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of an ion from one side of a membrane to the other up the solute's concentration gradient. This is carried out by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015075 ! ion transmembrane transporter activity
is_a: GO:0022804 ! active transmembrane transporter activity

[Term]
id: GO:0022854
name: obsolete active large uncharged polar molecule transmembrane transporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the transfer of a large uncharged polar molecule from one side of the membrane to the other, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport, ISBN:0815340729]
comment: This term was made obsolete because 'large uncharged polar molecule' is not a useful chemical grouping term.
synonym: "active large uncharged polar molecule transmembrane transporter activity" EXACT []
is_obsolete: true
replaced_by: GO:0022804

[Term]
id: GO:0022855
name: protein-N(PI)-phosphohistidine-glucose phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + glucose(out) = protein histidine + glucose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]
synonym: "glucose PTS transporter activity" EXACT []
is_a: GO:0005355 ! glucose transmembrane transporter activity
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity

[Term]
id: GO:0022856
name: protein-N(PI)-phosphohistidine-sorbitol phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sorbitol(out) = protein histidine + sorbitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]
synonym: "sorbitol PTS transporter activity" EXACT []
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
is_a: GO:0015576 ! sorbitol transmembrane transporter activity

[Term]
id: GO:0022857
name: transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0005386
alt_id: GO:0015646
def: "Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_yeast
subset: gosubset_prok
xref: Reactome:REACT_100033 "GLUT9 transports glucose, fructose and urate, Gallus gallus"
xref: Reactome:REACT_106735 "GLUT9 transports glucose, fructose and urate, Xenopus tropicalis"
xref: Reactome:REACT_111088 "Egress of internalized antigen to the cytosol via sec61, Homo sapiens"
xref: Reactome:REACT_111933 "GLUT9 transports glucose, fructose and urate, Plasmodium falciparum"
xref: Reactome:REACT_113047 "GLUT9 transports glucose, fructose and urate, Dictyostelium discoideum"
xref: Reactome:REACT_113116 "GLUT9 transports glucose, fructose and urate, Mycobacterium tuberculosis"
xref: Reactome:REACT_113829 "GLUT9 transports glucose, fructose and urate, Arabidopsis thaliana"
xref: Reactome:REACT_114161 "GLUT9 transports glucose, fructose and urate, Oryza sativa"
xref: Reactome:REACT_19288 "GLUT9 transports glucose, fructose and urate, Homo sapiens"
xref: Reactome:REACT_77235 "GLUT9 transports glucose, fructose and urate, Canis familiaris"
xref: Reactome:REACT_81225 "GLUT9 transports glucose, fructose and urate, Bos taurus"
xref: Reactome:REACT_88503 "GLUT9 transports glucose, fructose and urate, Taeniopygia guttata"
xref: Reactome:REACT_91849 "GLUT9 transports glucose, fructose and urate, Mus musculus"
xref: Reactome:REACT_94185 "GLUT9 transports glucose, fructose and urate, Rattus norvegicus"
is_a: GO:0005215 ! transporter activity
relationship: part_of GO:0055085 ! transmembrane transport

[Term]
id: GO:0022858
name: alanine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of alanine from one side of a membrane to the other. Alanine is 2-aminopropanoic acid." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0008324 ! cation transmembrane transporter activity
is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity
relationship: part_of GO:0032328 ! alanine transport

[Term]
id: GO:0022859
name: dephosphorylation-gated channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a solute by a channel that opens in response to dephosphorylation of one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0022836 ! gated channel activity

[Term]
id: GO:0022865
name: transmembrane electron transfer carrier
namespace: molecular_function
def: "Enables electron flow across a biological membrane, from donors localized on one side of the membrane to acceptors localized on the other side. These systems contribute to or subtract from the membrane potential, depending on the direction of electron flow. They are therefore important to cellular energetics." [GOC:mtg_transport, ISBN:0815340729, TC:5]
xref: TC:5
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0022866
name: transmembrane 1-electron transfer carrier
namespace: molecular_function
def: "Enables transfer of one electron across a membrane." [GOC:mtg_transport, ISBN:0815340729, TC:5.B]
synonym: "transmembrane one-electron transfer carrier" EXACT [GOC:mah]
is_a: GO:0022865 ! transmembrane electron transfer carrier

[Term]
id: GO:0022867
name: transmembrane 2-electron transfer carrier
namespace: molecular_function
def: "Enables transfer of two electrons across a membrane." [GOC:mtg_transport, ISBN:0815340729, TC:5.A]
synonym: "transmembrane two-electron transfer carrier" EXACT [GOC:mah]
is_a: GO:0022865 ! transmembrane electron transfer carrier

[Term]
id: GO:0022869
name: protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + lactose(out) = protein histidine + lactose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]
synonym: "lactose PTS transporter activity" EXACT []
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
is_a: GO:0015155 ! lactose transmembrane transporter activity

[Term]
id: GO:0022870
name: protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + mannose(out) = protein histidine + mannose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]
synonym: "mannose PTS transporter activity" EXACT []
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
is_a: GO:0015578 ! mannose transmembrane transporter activity

[Term]
id: GO:0022871
name: protein-N(PI)-phosphohistidine-sorbose phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sorbose(out) = protein histidine + sorbose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]
synonym: "sorbose PTS transporter activity" EXACT []
is_a: GO:0005355 ! glucose transmembrane transporter activity
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
is_a: GO:0019194 ! sorbose transmembrane transporter activity

[Term]
id: GO:0022872
name: protein-N(PI)-phosphohistidine-mannitol phosphotransferase system transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + mannitol(out) = protein histidine + mannitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]
synonym: "mannitol PTS transporter activity" EXACT []
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
is_a: GO:0015575 ! mannitol transmembrane transporter activity

[Term]
id: GO:0022873
name: protein-N(PI)-phosphohistidine-maltose phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + maltose(out) = protein histidine + maltose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]
synonym: "maltose PTS transporter activity" EXACT []
is_a: GO:0005363 ! maltose transmembrane transporter activity
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity

[Term]
id: GO:0022874
name: protein-N(PI)-phosphohistidine-cellobiose phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + cellobiose(out) = protein histidine + cellobiose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]
synonym: "cellobiose PTS transporter activity" EXACT []
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
is_a: GO:0019191 ! cellobiose transmembrane transporter activity

[Term]
id: GO:0022875
name: protein-N(PI)-phosphohistidine-galactitol phosphotransferase system transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + galactitol(out) = protein histidine + galactitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]
synonym: "galactitol PTS transporter activity" EXACT []
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
is_a: GO:0015577 ! galactitol transmembrane transporter activity

[Term]
id: GO:0022876
name: protein-N(PI)-phosphohistidine-galactosamine phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + galactosamine(out) = protein histidine + galactosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]
synonym: "galactosamine PTS transporter activity" EXACT []
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
is_a: GO:0019196 ! galactosamine transmembrane transporter activity

[Term]
id: GO:0022877
name: protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + fructose(out) = protein histidine + fructose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]
synonym: "fructose PTS transporter activity" EXACT []
is_a: GO:0005353 ! fructose transmembrane transporter activity
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity

[Term]
id: GO:0022878
name: protein-N(PI)-phosphohistidine-sucrose phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sucrose(out) = protein histidine + sucrose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]
synonym: "sucrose PTS transporter activity" EXACT []
xref: MetaCyc:SUCROSEPHOSPHO-RXN
is_a: GO:0008515 ! sucrose transmembrane transporter activity
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity

[Term]
id: GO:0022879
name: protein-N(PI)-phosphohistidine-trehalose phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + trehalose(out) = protein histidine + trehalose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]
synonym: "trehalose PTS transporter activity" EXACT []
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
is_a: GO:0015574 ! trehalose transmembrane transporter activity

[Term]
id: GO:0022880
name: protein-N(PI)-phosphohistidine-N-acetylglucosamine phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetylglucosamine(out) = protein histidine + N-acetylglucosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]
synonym: "N-acetylglucosamine PTS transporter activity" EXACT []
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
is_a: GO:0015572 ! N-acetylglucosamine transmembrane transporter activity
is_a: GO:0015574 ! trehalose transmembrane transporter activity

[Term]
id: GO:0022881
name: protein-N(PI)-phosphohistidine-N-acetylgalactosamine phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetylgalactosamine(out) = protein histidine + N-acetylgalactosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]
synonym: "N-acetylgalactosamine PTS transporter activity" EXACT []
is_a: GO:0005355 ! glucose transmembrane transporter activity
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
is_a: GO:0015571 ! N-acetylgalactosamine transmembrane transporter activity

[Term]
id: GO:0022882
name: protein-N(PI)-phosphohistidine-beta-glucoside phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + beta-glucoside(out) = protein histidine + beta-glucoside phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]
synonym: "beta-glucoside PTS transporter activity" EXACT []
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
is_a: GO:0015573 ! beta-glucoside transmembrane transporter activity

[Term]
id: GO:0022883
name: zinc efflux transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a zinc ion or zinc ions from the inside of the cell to the outside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729]
synonym: "zinc efflux permease activity" EXACT []
is_a: GO:0005385 ! zinc ion transmembrane transporter activity
is_a: GO:0046583 ! cation efflux transmembrane transporter activity

[Term]
id: GO:0022884
name: macromolecule transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a macromolecule from one side of the membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity

[Term]
id: GO:0022885
name: bacteriocin transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a bacteriocin from one side of the membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0015450 ! P-P-bond-hydrolysis-driven protein transmembrane transporter activity
is_a: GO:1904680 ! peptide transmembrane transporter activity
relationship: part_of GO:0043213 ! bacteriocin transport

[Term]
id: GO:0022886
name: channel-forming ionophore activity
namespace: molecular_function
def: "Enables transport of a solute across a membrane. This kind of transporter interacts much more weakly with the solute than the carrier does. It is an aqueous pore that extends across the membrane. It may change from closed to open and back. It transports faster than a carrier. It is always passive." [GOC:mtg_transport, ISBN:0815340729]
synonym: "ionophore activity" BROAD []
is_a: GO:0015267 ! channel activity

[Term]
id: GO:0022889
name: serine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of serine from one side of a membrane to the other. Serine is 2-amino-3-hydroxypropanoic acid." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0008324 ! cation transmembrane transporter activity
is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity
relationship: part_of GO:0032329 ! serine transport

[Term]
id: GO:0022890
name: inorganic cation transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015082
def: "Enables the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "di-, tri-valent inorganic cation transmembrane transporter activity" NARROW [GOC:mah]
is_a: GO:0008324 ! cation transmembrane transporter activity

[Term]
id: GO:0022891
name: substrate-specific transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0022857 ! transmembrane transporter activity
is_a: GO:0022892 ! substrate-specific transporter activity

[Term]
id: GO:0022892
name: substrate-specific transporter activity
namespace: molecular_function
def: "Enables the directed movement of a specific substance or group of related substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:mtg_transport]
subset: gosubset_prok
is_a: GO:0005215 ! transporter activity

[Term]
id: GO:0022893
name: low-affinity tryptophan transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015510
def: "Catalysis of the low-affinity transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [GOC:mtg_transport, ISBN:0815340729]
synonym: "low-affinity tryptophan permease activity" RELATED []
is_a: GO:0015196 ! L-tryptophan transmembrane transporter activity

[Term]
id: GO:0022894
name: Intermediate conductance calcium-activated potassium channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of potassium by a channel with a unit conductance of 20 to 85 picoSiemens that opens in response to stimulus by internal calcium ions. Intermediate conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, OMIM:602754]
synonym: "IK calcium-activated potassium channel activity" EXACT []
synonym: "IK KCa channels" EXACT []
synonym: "intermdiate conductance KCa channels" EXACT []
is_a: GO:0015269 ! calcium-activated potassium channel activity

[Term]
id: GO:0022897
name: proton-dependent peptide secondary active transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a peptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by proton movement." [GOC:mtg_transport]
subset: gosubset_prok
synonym: "hydrogen/oligopeptide symporter" RELATED []
is_a: GO:0015291 ! secondary active transmembrane transporter activity
is_a: GO:1904680 ! peptide transmembrane transporter activity
relationship: part_of GO:0015992 ! proton transport

[Term]
id: GO:0022898
name: regulation of transmembrane transporter activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transmembrane transporter activity." [GOC:dph, GOC:mtg_cardio, GOC:mtg_transport]
subset: gosubset_prok
is_a: GO:0032409 ! regulation of transporter activity
is_a: GO:0034762 ! regulation of transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0022857 ! transmembrane transporter activity
relationship: regulates GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0022900
name: electron transport chain
namespace: biological_process
def: "A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport]
subset: goslim_metagenomics
subset: gosubset_prok
xref: Wikipedia:Electron_transport_chain
is_a: GO:0006091 ! generation of precursor metabolites and energy
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0055114 ! oxidation-reduction process

[Term]
id: GO:0022904
name: respiratory electron transport chain
namespace: biological_process
def: "A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport, ISBN:0716720094]
subset: gosubset_prok
synonym: "6-phosphofructokinase reduction" RELATED []
synonym: "dihydrobiopterin reduction" RELATED []
synonym: "dihydrolipoamide reduction" RELATED []
synonym: "dihydrolipoylprotein reduction" RELATED []
synonym: "dihydropteridine reduction" RELATED []
synonym: "electron transfer" EXACT []
synonym: "other pathways of electron transport" RELATED []
synonym: "oxidized glutathione reduction" RELATED []
synonym: "protein-disulfide reduction" RELATED []
xref: Reactome:REACT_100934 "Respiratory electron transport, Rattus norvegicus"
xref: Reactome:REACT_101166 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., Drosophila melanogaster"
xref: Reactome:REACT_103686 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., Xenopus tropicalis"
xref: Reactome:REACT_104669 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., Sus scrofa"
xref: Reactome:REACT_105063 "Respiratory electron transport, Danio rerio"
xref: Reactome:REACT_107634 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., Caenorhabditis elegans"
xref: Reactome:REACT_108981 "Respiratory electron transport, Caenorhabditis elegans"
xref: Reactome:REACT_109327 "Respiratory electron transport, Arabidopsis thaliana"
xref: Reactome:REACT_110006 "Respiratory electron transport, Oryza sativa"
xref: Reactome:REACT_110577 "Respiratory electron transport, Canis familiaris"
xref: Reactome:REACT_22393 "Respiratory electron transport, Homo sapiens"
xref: Reactome:REACT_28852 "Respiratory electron transport, Bos taurus"
xref: Reactome:REACT_30009 "Respiratory electron transport, Sus scrofa"
xref: Reactome:REACT_30834 "Respiratory electron transport, Drosophila melanogaster"
xref: Reactome:REACT_31609 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., Saccharomyces cerevisiae"
xref: Reactome:REACT_33328 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., Taeniopygia guttata"
xref: Reactome:REACT_33999 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., Bos taurus"
xref: Reactome:REACT_38628 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., Schizosaccharomyces pombe"
xref: Reactome:REACT_6305 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., Homo sapiens"
xref: Reactome:REACT_78440 "Respiratory electron transport, Dictyostelium discoideum"
xref: Reactome:REACT_79453 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., Escherichia coli"
xref: Reactome:REACT_81477 "Respiratory electron transport, Mus musculus"
xref: Reactome:REACT_82198 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., Gallus gallus"
xref: Reactome:REACT_82340 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., Oryza sativa"
xref: Reactome:REACT_84453 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., Arabidopsis thaliana"
xref: Reactome:REACT_84989 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., Rattus norvegicus"
xref: Reactome:REACT_85095 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., Mus musculus"
xref: Reactome:REACT_86505 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., Canis familiaris"
xref: Reactome:REACT_86624 "Respiratory electron transport, Saccharomyces cerevisiae"
xref: Reactome:REACT_87707 "Respiratory electron transport, Schizosaccharomyces pombe"
xref: Reactome:REACT_88908 "Respiratory electron transport, Taeniopygia guttata"
xref: Reactome:REACT_89723 "Respiratory electron transport, Xenopus tropicalis"
xref: Reactome:REACT_89835 "Respiratory electron transport, Escherichia coli"
xref: Reactome:REACT_92603 "Respiratory electron transport, Gallus gallus"
xref: Reactome:REACT_93495 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., Mycobacterium tuberculosis"
xref: Reactome:REACT_93647 "Respiratory electron transport, Mycobacterium tuberculosis"
xref: Reactome:REACT_96847 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., Dictyostelium discoideum"
xref: Reactome:REACT_99140 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., Danio rerio"
xref: Wikipedia:Electron_transfer
is_a: GO:0022900 ! electron transport chain
relationship: part_of GO:0045333 ! cellular respiration

[Term]
id: GO:0023002
name: nuclear migration to embryo sac poles
namespace: biological_process
def: "Migration of the nuclei of the two-nucleate embryo sac to opposite poles of the cell." [GOC:jid, GOC:mtg_plant, ISBN:047186840X]
synonym: "nuclear migration to female gametophyte poles" EXACT []
synonym: "nuclear migration to megagametophyte poles" EXACT []
synonym: "nucleus migration to embryo sac poles" EXACT []
synonym: "nucleus migration to female gametophyte poles" EXACT []
synonym: "nucleus migration to megagametophyte poles" EXACT []
is_a: GO:0009562 ! embryo sac nuclear migration

[Term]
id: GO:0023003
name: nuclear migration to the embryo sac center
namespace: biological_process
def: "Migration of one of the four nuclei at each pole of the eight-nucleate embryo sac, to the center of the cell." [GOC:jid, GOC:mtg_plant, ISBN:047186840X]
synonym: "nuclear migration to the embryo sac centre" EXACT []
synonym: "nuclear migration to the female gametophyte center" EXACT []
synonym: "nuclear migration to the female gametophyte centre" EXACT []
synonym: "nuclear migration to the megagametophyte center" EXACT []
synonym: "nuclear migration to the megagametophyte centre" EXACT []
synonym: "nucleus migration to the female gametophyte center" EXACT []
synonym: "nucleus migration to the female gametophyte centre" EXACT []
is_a: GO:0009562 ! embryo sac nuclear migration

[Term]
id: GO:0023004
name: obsolete activation of dopamine receptor signaling pathway
namespace: biological_process
def: "OBSOLETE. Any process that initiates the dopamine receptor protein signaling pathway through stimulation of the dopamine receptor." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "activation of dopamine receptor signaling pathway" EXACT []
synonym: "activation of dopamine receptor signalling pathway" EXACT [GOC:mah]
synonym: "initiation of dopamine receptor signaling pathway" RELATED []
synonym: "stimulation of dopamine receptor signaling pathway" EXACT []
is_obsolete: true
consider: GO:0060161
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023005
name: obsolete signal initiation by neurotransmitter
namespace: biological_process
def: "OBSOLETE. The process in which a neurotransmitter signal causes activation of a receptor." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "signal initiation by neurotransmitter" EXACT []
is_obsolete: true
consider: GO:0007165
consider: GO:0030594
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023006
name: obsolete signal initiation by amino acid
namespace: biological_process
def: "OBSOLETE. The process in which an amino acid signal causes activation of a receptor." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "signal initiation by amino acid" EXACT []
is_obsolete: true
consider: GO:0007215
consider: GO:0008066
consider: GO:0071230
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023007
name: obsolete ligand binding to T cell receptor
namespace: biological_process
def: "OBSOLETE. Binding of a diffusible ligand to a T cell receptor as part of a signaling process." [GOC:jid, GOC:mtg_signal]
comment: This term was made obsolete because it is describing a binding molecular function.
synonym: "ligand binding to T cell receptor" EXACT []
is_obsolete: true
consider: GO:0042101
consider: GO:0042608
consider: GO:0050852
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023009
name: obsolete initiation of T cell receptor signaling
namespace: biological_process
def: "OBSOLETE. The process in which a signal causes activation of T cell receptor signaling." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "initiation of T cell receptor signaling" EXACT []
synonym: "initiation of T cell receptor signalling" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0004872
consider: GO:0042101
consider: GO:0048018
consider: GO:0050852
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023010
name: obsolete regulation of initiation of T cell receptor signaling
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the initiation of T cell receptor signaling." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "regulation of initiation of T cell receptor signaling" EXACT []
synonym: "regulation of initiation of T cell receptor signalling" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0050856
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023011
name: obsolete positive regulation of initiation of T cell receptor signaling
namespace: biological_process
def: "OBSOLETE. Any process that activates, maintains or increases the frequency, rate or extent of the initiation of T cell receptor signaling." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "positive regulation of initiation of T cell receptor signaling" EXACT []
synonym: "positive regulation of initiation of T cell receptor signalling" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0050862
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023012
name: obsolete initiation of T cell receptor signaling by binding of a MHC complex to T cell receptor
namespace: biological_process
def: "OBSOLETE. The process in which binding of an MHC complex to T cell receptor causes activation of T cell receptor signaling." [GOC:mtg_signal]
comment: This term was made obsolete because it is describing a binding molecular function.
synonym: "initiation of T cell receptor signaling by binding of a MHC complex to T cell receptor" EXACT []
synonym: "initiation of T cell receptor signalling by binding of a MHC complex to T cell receptor" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0042101
consider: GO:0050852
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023014
name: signal transduction by protein phosphorylation
namespace: biological_process
def: "A process in which the transfer of one or more phosphate groups to a substrate transmits a signal to the phosphorylated substrate." [GOC:mtg_signal, GOC:signaling]
synonym: "signal transduction via phosphorylation event" RELATED [GOC:bf]
synonym: "signal transmission via phosphorylation event" RELATED [GOC:bf]
is_a: GO:0006468 ! protein phosphorylation
is_a: GO:0007165 ! signal transduction
is_a: GO:0044710 ! single-organism metabolic process
is_a: GO:0044763 ! single-organism cellular process
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023015
name: signal transduction by cis-phosphorylation
namespace: biological_process
def: "A process in which the transfer of one or more phosphate groups by a kinase to a residue in the same kinase molecule transmits a signal. For example, ligand-binding can induce autophosphorylation of the activated receptor, creating binding sites for intracellular signaling molecules." [GOC:bf, GOC:mtg_signal, GOC:signaling]
synonym: "signal transduction via a cis-phosphorylation event" RELATED [GOC:bf]
synonym: "signal transmission via a cis-phosphorylation event" RELATED [GOC:bf]
synonym: "signal transmission via auto-phosphorylation" RELATED []
is_a: GO:0023014 ! signal transduction by protein phosphorylation
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023016
name: signal transduction by trans-phosphorylation
namespace: biological_process
def: "A process in which the transfer of one or more phosphate groups by a kinase to a residue in a different protein molecule transmits a signal." [GOC:bf, GOC:mtg_signal]
synonym: "signal transduction via a trans-phosphorylation event" RELATED [GOC:bf]
synonym: "signal transmission via a trans-phosphorylation event" RELATED [GOC:bf]
is_a: GO:0023014 ! signal transduction by protein phosphorylation
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023017
name: obsolete signal transmission via diffusible molecule
namespace: biological_process
def: "OBSOLETE. The process in which a signal is conveyed via a diffusible molecule." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "signal transmission via diffusible molecule" EXACT []
synonym: "signaling via diffusible mediator" EXACT []
is_obsolete: true
consider: GO:0007267
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023018
name: obsolete T cell activation of signal transmission via diffusible molecule
namespace: biological_process
def: "OBSOLETE. The process in which signal transmission via a diffusible molecule is initiated by a T cell." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "T cell activation of signal transmission via diffusible molecule" EXACT []
is_obsolete: true
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023019
name: signal transduction involved in regulation of gene expression
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another." [GOC:mtg_signal]
synonym: "regulation of gene expression as a consequence of signal transmission" RELATED [GOC:bf]
is_a: GO:0007165 ! signal transduction
intersection_of: GO:0007165 ! signal transduction
intersection_of: part_of GO:0010468 ! regulation of gene expression
relationship: part_of GO:0010468 ! regulation of gene expression
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023020
name: obsolete regulation of gene expression as a consequence of T cell signal transmission
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a T cell signal is released and/or conveyed from one location to another." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "regulation of gene expression as a consequence of T cell signal transmission" EXACT []
is_obsolete: true
consider: GO:0023019
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023021
name: termination of signal transduction
namespace: biological_process
def: "The signaling process in which signal transduction is brought to an end rather than being reversibly modulated." [GOC:mtg_signal]
comment: Note that this term encompasses both the control point when the instruction is given for the process to cease and the actual cessation of the process. A process can persist for some time after that signal that induced the process is withdrawn.
is_a: GO:0009968 ! negative regulation of signal transduction
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023022
name: termination of T cell signal transduction
namespace: biological_process
def: "The signaling process in which T cell signal transduction is brought to an end rather than being reversibly modulated." [GOC:mtg_signal]
is_a: GO:0023021 ! termination of signal transduction
is_a: GO:0050860 ! negative regulation of T cell receptor signaling pathway
relationship: part_of GO:0050852 ! T cell receptor signaling pathway
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023023
name: MHC protein complex binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the major histocompatibility complex." [GOC:mtg_signal, GOC:vw]
is_a: GO:0003823 ! antigen binding
is_a: GO:0032403 ! protein complex binding
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023024
name: MHC class I protein complex binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the class I major histocompatibility complex." [GOC:mtg_signal, GOC:vw]
is_a: GO:0023023 ! MHC protein complex binding
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023025
name: MHC class Ib protein complex binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the class Ib major histocompatibility complex." [GOC:mtg_signal, GOC:vw]
is_a: GO:0023023 ! MHC protein complex binding
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023026
name: MHC class II protein complex binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the class II major histocompatibility complex." [GOC:mtg_signal, GOC:vw]
is_a: GO:0023023 ! MHC protein complex binding
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023027
name: MHC class I protein binding, via antigen binding groove
namespace: molecular_function
def: "Interacting selectively and non-covalently with major histocompatibility complex class I molecules via the antigen binding groove." [GOC:mtg_signal, GOC:vw]
is_a: GO:0042288 ! MHC class I protein binding
relationship: part_of GO:0023024 ! MHC class I protein complex binding
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023028
name: MHC class I protein binding, via lateral surface
namespace: molecular_function
def: "Interacting selectively and non-covalently with major histocompatibility complex class I molecules via the lateral surface." [GOC:mtg_signal, GOC:vw]
is_a: GO:0042288 ! MHC class I protein binding
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023029
name: MHC class Ib protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with major histocompatibility complex class Ib molecules." [GOC:mtg_signal, GOC:vw]
is_a: GO:0042287 ! MHC protein binding
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023030
name: MHC class Ib protein binding, via antigen binding groove
namespace: molecular_function
def: "Interacting selectively and non-covalently with major histocompatibility complex class Ib molecules via the antigen binding groove." [GOC:mtg_signal, GOC:vw]
is_a: GO:0023029 ! MHC class Ib protein binding
relationship: part_of GO:0023025 ! MHC class Ib protein complex binding
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023031
name: MHC class Ib protein binding, via lateral surface
namespace: molecular_function
def: "Interacting selectively and non-covalently with major histocompatibility complex class Ib molecules via the lateral surface." [GOC:mtg_signal, GOC:vw]
is_a: GO:0023029 ! MHC class Ib protein binding
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023035
name: CD40 signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of the cell surface receptor CD40 to one of its physiological ligands, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mtg_signal, GOC:signaling, PMID:11348017]
synonym: "CD40 signalling pathway" EXACT [GOC:mah]
is_a: GO:0007166 ! cell surface receptor signaling pathway
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023036
name: obsolete initiation of signal transduction
namespace: biological_process
def: "OBSOLETE. The process in which a signal causes activation of a receptor, for example, via a conformation change." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous. Note that this term was intended for the annotation of both ligands and receptors.
synonym: "initiation of signal transduction" EXACT []
synonym: "signal reception" RELATED []
is_obsolete: true
consider: GO:0004872
consider: GO:0007165
consider: GO:0048018
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023037
name: obsolete signal initiation by light
namespace: biological_process
def: "OBSOLETE. The process in which a light signal causes activation of a receptor." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "signal initiation by light" EXACT []
is_obsolete: true
consider: GO:0009785
consider: GO:0009881
consider: GO:0010017
consider: GO:0010018
consider: GO:0010161
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023038
name: obsolete signal initiation by diffusible mediator
namespace: biological_process
def: "OBSOLETE. The process in which a diffusible signal causes activation of a receptor." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "signal initiation by diffusible mediator" EXACT []
is_obsolete: true
consider: GO:0004872
consider: GO:0007165
consider: GO:0038001
consider: GO:0048018
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023039
name: obsolete signal initiation by physical damage
namespace: biological_process
def: "OBSOLETE. The process in which a physical damage signal causes activation of a receptor." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "signal initiation by physical damage" EXACT []
is_obsolete: true
consider: GO:0004872
consider: GO:0033554
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023040
name: obsolete signaling via ionic flux
namespace: biological_process
def: "OBSOLETE. The process in which information is sent from one location to another, within a living organism or between living organisms, via ionic flux." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "signaling via ionic flux" EXACT []
synonym: "signalling via ionic flux" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0023052
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023041
name: neuronal signal transduction
namespace: biological_process
def: "The process in which an activated neuronal cell receptor conveys information down a signaling pathway, resulting in a change in the function or state of a cell. This process may be intracellular or intercellular." [GOC:mtg_signal]
is_a: GO:0007165 ! signal transduction
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023042
name: obsolete signaling via protein/peptide mediator
namespace: biological_process
def: "OBSOLETE. The process in which information is sent from one location to another, within a living organism or between living organisms, via a protein/peptide mediator." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "signaling via protein/peptide mediator" EXACT []
synonym: "signalling via protein/peptide mediator" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0023052
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023043
name: obsolete signaling via lipid mediator
namespace: biological_process
def: "OBSOLETE. The process in which information is sent from one location to another, within a living organism or between living organisms, via a lipid mediator." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "signaling via lipid mediator" EXACT []
synonym: "signalling via lipid mediator" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0014065
consider: GO:0023052
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023044
name: obsolete signaling via chemical mediator
namespace: biological_process
def: "OBSOLETE. The process in which information is sent from one location to another, within a living organism or between living organisms, via a chemical mediator." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "signaling via chemical mediator" EXACT []
synonym: "signalling via chemical mediator" EXACT [GOC:mah]
is_obsolete: true
consider: GO:0023052
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023045
name: signal transduction by conformational transition
namespace: biological_process
def: "A process where induction of a conformational change in a molecule transmits a signal to that molecule." [GOC:bf, GOC:mtg_signal]
synonym: "signal transduction via conformational transition" RELATED [GOC:bf]
synonym: "signal transmission via conformational transition" RELATED [GOC:bf]
is_a: GO:0007165 ! signal transduction
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023047
name: obsolete signal initiation by chemical mediator
namespace: biological_process
def: "OBSOLETE. The process in which a chemical signal causes activation of a receptor." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "signal initiation by chemical mediator" EXACT []
is_obsolete: true
consider: GO:0004872
consider: GO:0007165
consider: GO:0070887
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023048
name: obsolete signal initiation by lipid mediator
namespace: biological_process
def: "OBSOLETE. The process in which a lipid signal causes activation of a receptor." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "signal initiation by lipid mediator" EXACT []
is_obsolete: true
consider: GO:0007165
consider: GO:0045125
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023049
name: obsolete signal initiation by protein/peptide mediator
namespace: biological_process
def: "OBSOLETE. The process in which a protein/peptide signal causes activation of a receptor." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "signal initiation by protein/peptide mediator" EXACT []
is_obsolete: true
consider: GO:0004872
consider: GO:0007165
consider: GO:0048018
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023050
name: obsolete consequence of signal transmission
namespace: biological_process
def: "OBSOLETE. The steps whereby the downstream processes started by a signal are brought to a conclusion. Examples include destruction of cAMP by PDE, or endocytosis resulting from receptor phosphorylation. The termination process ends when the receptor has returned to its inactive state." [GOC:mtg_signal]
comment: This term was made obsolete because the term is no longer needed.
synonym: "consequence of signal transmission" EXACT []
synonym: "signal termination" EXACT []
is_obsolete: true
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023051
name: regulation of signaling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal]
synonym: "regulation of signaling process" RELATED [GOC:bf]
synonym: "regulation of signalling process" RELATED [GOC:mah]
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0023052 ! signaling
relationship: regulates GO:0023052 ! signaling
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023052
name: signaling
namespace: biological_process
alt_id: GO:0023046
def: "The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered." [GOC:mtg_signal, GOC:mtg_signaling_feb11, GOC:signaling]
comment: Note that a signal is any variable property or parameter that serves to convey information, and may be a physical entity such as a gene product or small molecule, a photon, or a change in state such as movement or voltage change.
subset: goslim_pombe
subset: goslim_yeast
synonym: "biological signaling" EXACT []
synonym: "signaling process" EXACT []
synonym: "signalling" EXACT []
synonym: "signalling process" RELATED [GOC:mah]
is_a: GO:0008150 ! biological_process
disjoint_from: GO:0044848 ! biological phase
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023053
name: obsolete signal initiation by mechanical effect
namespace: biological_process
def: "OBSOLETE. The process in which a mechanical signal causes activation of a receptor." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "signal initiation by mechanical effect" EXACT []
is_obsolete: true
consider: GO:0004872
consider: GO:0007165
consider: GO:0071260
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023054
name: obsolete signal initiation by stretch effect
namespace: biological_process
def: "OBSOLETE. The process in which a stretch signal causes activation of a receptor." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "signal initiation by stretch effect" EXACT []
is_obsolete: true
consider: GO:0004872
consider: GO:0007165
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023055
name: obsolete signal initiation by peptide hormone
namespace: biological_process
def: "OBSOLETE. The process in which a signal is initiated by a peptide hormone." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "signal initiation by peptide hormone" EXACT []
is_obsolete: true
consider: GO:0004879
consider: GO:0005179
consider: GO:0009755
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023056
name: positive regulation of signaling
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of a signaling process." [GOC:mtg_signal]
synonym: "positive regulation of signaling process" RELATED [GOC:bf]
synonym: "positive regulation of signalling process" EXACT [GOC:mah]
is_a: GO:0023051 ! regulation of signaling
is_a: GO:0048518 ! positive regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0023052 ! signaling
relationship: positively_regulates GO:0023052 ! signaling
relationship: positively_regulates GO:0044700 ! single organism signaling
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023057
name: negative regulation of signaling
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process." [GOC:mtg_signal]
synonym: "negative regulation of signaling process" RELATED [GOC:bf]
synonym: "negative regulation of signalling process" RELATED [GOC:mah]
is_a: GO:0023051 ! regulation of signaling
is_a: GO:0048519 ! negative regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0023052 ! signaling
relationship: negatively_regulates GO:0023052 ! signaling
relationship: negatively_regulates GO:0044700 ! single organism signaling
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023058
name: adaptation of signaling pathway
namespace: biological_process
def: "The regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus." [GOC:mtg_signal]
synonym: "adaptation of signalling pathway" EXACT [GOC:mah]
is_a: GO:0009966 ! regulation of signal transduction
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023059
name: positive adaptation of signaling pathway
namespace: biological_process
def: "The positive regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus." [GOC:mtg_signal]
synonym: "positive adaptation of signalling pathway" EXACT [GOC:mah]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0023058 ! adaptation of signaling pathway
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023060
name: obsolete signal transmission
namespace: biological_process
def: "OBSOLETE. The process in which a signal is released and/or conveyed from one location to another." [GOC:mtg_signal]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "signal transmission" EXACT []
is_obsolete: true
consider: GO:0023052
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023061
name: signal release
namespace: biological_process
def: "The process in which a signal is secreted or discharged into the extracellular medium from a cellular source." [GOC:mtg_signal]
synonym: "signal secretion" EXACT [GOC:bf]
is_a: GO:0032940 ! secretion by cell
intersection_of: GO:0032940 ! secretion by cell
intersection_of: part_of GO:0007267 ! cell-cell signaling
relationship: part_of GO:0007267 ! cell-cell signaling
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023062
name: obsolete signal transmission via transcytosis
namespace: biological_process
def: "OBSOLETE. The process in which a signal is conveyed via transcytosis. Transcytosis is the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side." [GOC:mtg_signal, ISBN:0716731363]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "signal transmission via transcytosis" EXACT []
is_obsolete: true
consider: GO:0023052
consider: GO:0045056
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023065
name: obsolete signal transmission via blood
namespace: biological_process
def: "OBSOLETE. The process in which a signal is conveyed via blood." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "signal transmission via blood" EXACT []
is_obsolete: true
consider: GO:0010232
consider: GO:0023052
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023066
name: obsolete signal transmission via vascular system
namespace: biological_process
def: "OBSOLETE. The process in which a signal is conveyed via the vascular system." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "signal transmission via vascular system" EXACT []
is_obsolete: true
consider: GO:0010232
consider: GO:0023052
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023067
name: obsolete signal transmission via lymphatic system
namespace: biological_process
def: "OBSOLETE. The process in which a signal is conveyed via the lymphatic system." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "signal transmission via lymphatic system" EXACT []
is_obsolete: true
consider: GO:0023052
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023068
name: obsolete signal transmission via phloem
namespace: biological_process
def: "OBSOLETE. The process in which a signal is conveyed via the phloem." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "signal transmission via phloem" EXACT []
is_obsolete: true
consider: GO:0010233
consider: GO:0023052
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023069
name: obsolete signal transmission via xylem
namespace: biological_process
def: "OBSOLETE. The process in which a signal is conveyed via the xylem." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "signal transmission via xylem" EXACT []
is_obsolete: true
consider: GO:0010232
consider: GO:0023052
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023070
name: obsolete signal transmission via air
namespace: biological_process
def: "OBSOLETE. The process in which a signal is conveyed via the air." [GOC:mtg_signal]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "signal transmission via air" EXACT []
is_obsolete: true
consider: GO:0035636
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0030001
name: metal ion transport
namespace: biological_process
def: "The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "heavy metal ion transport" NARROW []
is_a: GO:0006812 ! cation transport

[Term]
id: GO:0030002
name: cellular anion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of anions at the level of a cell." [GOC:ceb, GOC:mah]
is_a: GO:0006873 ! cellular ion homeostasis
is_a: GO:0055081 ! anion homeostasis

[Term]
id: GO:0030003
name: cellular cation homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of cations at the level of a cell." [GOC:ceb, GOC:mah]
subset: gosubset_prok
is_a: GO:0006873 ! cellular ion homeostasis
is_a: GO:0055080 ! cation homeostasis

[Term]
id: GO:0030004
name: cellular monovalent inorganic cation homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of monovalent inorganic cations at the level of a cell." [GOC:ai, GOC:mah]
subset: gosubset_prok
is_a: GO:0030003 ! cellular cation homeostasis
is_a: GO:0055067 ! monovalent inorganic cation homeostasis

[Term]
id: GO:0030005
name: obsolete cellular di-, tri-valent inorganic cation homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of divalent or trivalent cations at the level of a cell." [GOC:ceb, GOC:mah]
subset: gosubset_prok
synonym: "cellular di-, tri-valent inorganic cation homeostasis" EXACT []
is_obsolete: true
consider: GO:0072503
consider: GO:0072504

[Term]
id: GO:0030006
name: obsolete heavy cellular metal ion homeostasis
namespace: biological_process
def: "OBSOLETE. Regulation of the levels, transport, and metabolism of ions of a heavy metal, a metal that can form a coordination bond with a protein, as opposed to an alkali or alkaline-earth metal that can only form an ionic bond; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn." [GOC:kd, GOC:mah]
comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information).
synonym: "heavy cellular metal ion homeostasis" EXACT []
is_obsolete: true
consider: GO:0006875

[Term]
id: GO:0030007
name: cellular potassium ion homeostasis
namespace: biological_process
alt_id: GO:0017079
def: "Any process involved in the maintenance of an internal steady state of potassium ions at the level of a cell." [GOC:mah]
is_a: GO:0006875 ! cellular metal ion homeostasis
is_a: GO:0030004 ! cellular monovalent inorganic cation homeostasis
is_a: GO:0055075 ! potassium ion homeostasis

[Term]
id: GO:0030008
name: TRAPP complex
namespace: cellular_component
def: "A large complex that acts as a tethering factor involved in transporting vesicles from the ER through the Golgi to the plasma membrane. A TRAPP (transport protein particle) complex has a core set of proteins which are joined by specific subunits depending on the cellular component where a given TRAPP complex is active." [GOC:bhm, GOC:vw, PMID:22669257]
synonym: "transport protein particle" EXACT []
synonym: "transport protein particle complex" EXACT [GOC:bhm]
synonym: "TRAPP1" NARROW [GOC:vw]
synonym: "TRAPP2" NARROW [GOC:vw]
xref: Wikipedia:TRAPP_complex
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0030009
name: obsolete complement factor H activity
namespace: molecular_function
def: "OBSOLETE. A cofactor for the serine protease complement factor I." [ISBN:0198547684]
comment: This term was made obsolete because it represents a gene product.
synonym: "complement factor H activity" EXACT []
is_obsolete: true
consider: GO:0006956

[Term]
id: GO:0030010
name: establishment of cell polarity
namespace: biological_process
alt_id: GO:0000283
alt_id: GO:0030468
def: "The specification and formation of anisotropic intracellular organization or cell growth patterns." [GOC:mah]
synonym: "bud site selection/establishment of cell polarity" NARROW []
synonym: "cell polarization" EXACT []
is_a: GO:0007163 ! establishment or maintenance of cell polarity

[Term]
id: GO:0030011
name: maintenance of cell polarity
namespace: biological_process
alt_id: GO:0030013
alt_id: GO:0030469
def: "The maintenance of established anisotropic intracellular organization or cell growth patterns." [GOC:mah]
is_a: GO:0007163 ! establishment or maintenance of cell polarity

[Term]
id: GO:0030014
name: CCR4-NOT complex
namespace: cellular_component
def: "The evolutionarily conserved CCR4-NOT complex is involved in several aspects of mRNA metabolism, including repression and activation of mRNA initiation, control of mRNA elongation, and the deadenylation and subsequent degradation of mRNA. In Saccharomyces the CCR4-NOT complex comprises a core complex of 9 proteins (Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p), Caf4p, Caf16p, and several less well characterized proteins." [GOC:sart, PMID:11113136]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0030015
name: CCR4-NOT core complex
namespace: cellular_component
def: "The core of the CCR4-NOT complex. In Saccharomyces the CCR4-NOT core complex comprises Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p." [GOC:sart, PMID:11113136]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0030014 ! CCR4-NOT complex

[Term]
id: GO:0030016
name: myofibril
namespace: cellular_component
def: "The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism." [ISBN:0815316194]
synonym: "striated muscle fiber" RELATED []
synonym: "striated muscle fibre" RELATED []
xref: Wikipedia:Myofibril
is_a: GO:0043292 ! contractile fiber

[Term]
id: GO:0030017
name: sarcomere
namespace: cellular_component
def: "The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [ISBN:0815316194]
xref: Wikipedia:Sarcomere
is_a: GO:0044449 ! contractile fiber part
relationship: part_of GO:0030016 ! myofibril

[Term]
id: GO:0030018
name: Z disc
namespace: cellular_component
def: "Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194]
synonym: "Z band" EXACT []
synonym: "Z disk" EXACT []
synonym: "Z line" EXACT []
is_a: GO:0044449 ! contractile fiber part
relationship: part_of GO:0031674 ! I band

[Term]
id: GO:0030019
name: obsolete tryptase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa, Lys-Xaa, but with more restricted specificity than trypsin." [EC:3.4.21.59]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "lung tryptase activity" NARROW [EC:3.4.21.59]
synonym: "mast cell neutral proteinase activity" EXACT [EC:3.4.21.59]
synonym: "mast cell protease II activity" NARROW [EC:3.4.21.59]
synonym: "mast cell proteinase II" RELATED [EC:3.4.21.59]
synonym: "mast cell serine proteinase II" RELATED [EC:3.4.21.59]
synonym: "mast cell serine proteinase tryptase activity" EXACT [EC:3.4.21.59]
synonym: "mast cell tryptase activity" NARROW [EC:3.4.21.59]
synonym: "pituitary tryptase activity" NARROW [EC:3.4.21.59]
synonym: "rat mast cell protease II" RELATED [EC:3.4.21.59]
synonym: "skin tryptase activity" NARROW [EC:3.4.21.59]
synonym: "tryptase activity" EXACT []
synonym: "tryptase M" RELATED [EC:3.4.21.59]
xref: EC:3.4.21.59
xref: MetaCyc:3.4.21.59-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0030020
name: extracellular matrix structural constituent conferring tensile strength
namespace: molecular_function
def: "A constituent of the extracellular matrix that enables the matrix to resist longitudinal stress." [GOC:mah, ISBN:0815316194]
is_a: GO:0005201 ! extracellular matrix structural constituent

[Term]
id: GO:0030021
name: extracellular matrix structural constituent conferring compression resistance
namespace: molecular_function
def: "A constituent of the extracellular matrix that enables the matrix to resist compressive forces; often a proteoglycan." [GOC:mah, ISBN:0815316194]
is_a: GO:0005201 ! extracellular matrix structural constituent

[Term]
id: GO:0030022
name: obsolete adhesive extracellular matrix constituent
namespace: molecular_function
def: "OBSOLETE. A constituent of the extracellular matrix that facilitates attachment of cells to the matrix." [GOC:mah, ISBN:0815316194]
comment: This term was made obsolete because it does not represent a molecular function.
synonym: "adhesive extracellular matrix constituent" EXACT []
is_obsolete: true
consider: GO:0005578
consider: GO:0030674
consider: GO:0050839
consider: GO:0050840

[Term]
id: GO:0030023
name: extracellular matrix constituent conferring elasticity
namespace: molecular_function
def: "A component of the extracellular matrix that enables the matrix to recoil after transient stretching." [GOC:mah, ISBN:0815316194]
synonym: "elastin" RELATED []
is_a: GO:0005201 ! extracellular matrix structural constituent
is_a: GO:0097493 ! structural molecule activity conferring elasticity

[Term]
id: GO:0030026
name: cellular manganese ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of manganese ions at the level of a cell." [GOC:mah]
subset: gosubset_prok
synonym: "manganese homeostasis" BROAD []
is_a: GO:0046916 ! cellular transition metal ion homeostasis
is_a: GO:0055071 ! manganese ion homeostasis

[Term]
id: GO:0030027
name: lamellipodium
namespace: cellular_component
def: "A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments." [ISBN:0815316194]
xref: Wikipedia:Lamellipodia
is_a: GO:0042995 ! cell projection
relationship: part_of GO:0031252 ! cell leading edge

[Term]
id: GO:0030029
name: actin filament-based process
namespace: biological_process
def: "Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins." [GOC:mah]
synonym: "microfilament-based process" RELATED []
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0030030
name: cell projection organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/]
subset: gosubset_prok
synonym: "cell projection organisation" EXACT [GOC:curators]
synonym: "cell projection organization and biogenesis" RELATED [GOC:mah]
synonym: "cell surface structure organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0016043 ! cellular component organization
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0030031
name: cell projection assembly
namespace: biological_process
def: "Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/]
subset: goslim_metagenomics
subset: gosubset_prok
synonym: "cell projection biogenesis" RELATED [GOC:mah]
synonym: "formation of a cell surface projection" EXACT []
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0030030 ! cell projection organization

[Term]
id: GO:0030032
name: lamellipodium assembly
namespace: biological_process
def: "Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:mah, ISBN:0815316194]
synonym: "lamellipodium biogenesis" RELATED [GOC:mah]
synonym: "lamellipodium biosynthesis" EXACT []
synonym: "lamellipodium formation" EXACT []
is_a: GO:0030031 ! cell projection assembly
is_a: GO:0097581 ! lamellipodium organization

[Term]
id: GO:0030033
name: microvillus assembly
namespace: biological_process
def: "Formation of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell." [GOC:mah, ISBN:0815316194]
synonym: "microvillus biogenesis" RELATED [GOC:mah]
is_a: GO:0030031 ! cell projection assembly
is_a: GO:0032528 ! microvillus organization

[Term]
id: GO:0030034
name: microvillar actin bundle assembly
namespace: biological_process
def: "Assembly of the parallel bundle of actin filaments at the core of a microvillus." [GOC:mah]
is_a: GO:0030046 ! parallel actin filament bundle assembly
relationship: part_of GO:0030033 ! microvillus assembly

[Term]
id: GO:0030035
name: microspike assembly
namespace: biological_process
def: "Formation of a microspike, a dynamic, actin-rich projection extending from the surface of a migrating animal cell." [ISBN:0815316194, PMID:11429692, PMID:12153987, PMID:19095735]
comment: Although in some literature 'microspike' and 'filopodium' are used synonymously, in GO microspike refers to a cell projection that is distinct from a filopodium. For the assembly of filopodia, use 'filopodium assembly ; GO:0046847'.
synonym: "microspike biogenesis" RELATED [GOC:mah]
synonym: "microspike biosynthesis" EXACT []
synonym: "microspike formation" EXACT []
is_a: GO:0030031 ! cell projection assembly

[Term]
id: GO:0030036
name: actin cytoskeleton organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]
synonym: "actin cytoskeleton organisation" EXACT [GOC:curators]
synonym: "actin cytoskeleton organization and biogenesis" RELATED [GOC:mah]
synonym: "actin modulating activity" RELATED []
is_a: GO:0007010 ! cytoskeleton organization
is_a: GO:0030029 ! actin filament-based process
is_a: GO:1902589 ! single-organism organelle organization

[Term]
id: GO:0030037
name: actin filament reorganization involved in cell cycle
namespace: biological_process
def: "The cell cycle process in which rearrangement of the spatial distribution of actin filaments and associated proteins occurs." [GOC:mah]
synonym: "actin filament reorganisation involved in cell cycle" EXACT [GOC:mah]
synonym: "actin filament reorganization during cell cycle" RELATED [GOC:dph, GOC:tb]
is_a: GO:0022402 ! cell cycle process
is_a: GO:0090527 ! actin filament reorganization
intersection_of: GO:0090527 ! actin filament reorganization
intersection_of: part_of GO:0007049 ! cell cycle
relationship: part_of GO:0007049 ! cell cycle

[Term]
id: GO:0030038
name: contractile actin filament bundle assembly
namespace: biological_process
def: "Assembly of actin filament bundles in which the filaments are loosely packed (approximately 30-60 nm apart) and arranged with opposing polarities; the loose packing allows myosin (usually myosin-II) to enter the bundle." [GOC:mah, ISBN:0815316194]
is_a: GO:0051017 ! actin filament bundle assembly

[Term]
id: GO:0030039
name: obsolete DNA unwinding factor
namespace: molecular_function
alt_id: GO:0017152
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it does not represent a true molecular function.
synonym: "DNA unwinding factor" EXACT []
is_obsolete: true
replaced_by: GO:0006268

[Term]
id: GO:0030041
name: actin filament polymerization
namespace: biological_process
def: "Assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]
synonym: "actin polymerization" EXACT []
synonym: "actin polymerizing activity" RELATED []
is_a: GO:0008154 ! actin polymerization or depolymerization
is_a: GO:0051258 ! protein polymerization

[Term]
id: GO:0030042
name: actin filament depolymerization
namespace: biological_process
def: "Disassembly of actin filaments by the removal of actin monomers from a filament." [GOC:mah]
synonym: "actin depolymerization" EXACT []
synonym: "actin depolymerizing activity" RELATED []
is_a: GO:0008154 ! actin polymerization or depolymerization
is_a: GO:0051261 ! protein depolymerization

[Term]
id: GO:0030043
name: actin filament fragmentation
namespace: biological_process
def: "The severing of actin filaments into numerous short fragments, usually mediated by actin severing proteins." [GOC:mah, ISBN:0815316194]
is_a: GO:0030042 ! actin filament depolymerization

[Term]
id: GO:0030046
name: parallel actin filament bundle assembly
namespace: biological_process
def: "Assembly of actin filament bundles in which the filaments are tightly packed (approximately 10-20 nm apart) and oriented with the same polarity." [GOC:mah, ISBN:0815316194]
is_a: GO:0051017 ! actin filament bundle assembly

[Term]
id: GO:0030047
name: actin modification
namespace: biological_process
alt_id: GO:0007013
def: "Covalent modification of an actin molecule." [GOC:mah]
is_a: GO:0006464 ! cellular protein modification process
is_a: GO:0030036 ! actin cytoskeleton organization
is_a: GO:0044710 ! single-organism metabolic process

[Term]
id: GO:0030048
name: actin filament-based movement
namespace: biological_process
def: "Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins." [GOC:BHF, GOC:mah]
is_a: GO:0006928 ! movement of cell or subcellular component
is_a: GO:0030029 ! actin filament-based process

[Term]
id: GO:0030049
name: muscle filament sliding
namespace: biological_process
def: "The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated." [GOC:mah, GOC:mtg_muscle, ISBN:0815316194]
xref: Reactome:REACT_109611 "Striated Muscle Contraction, Gallus gallus"
xref: Reactome:REACT_16969 "Striated Muscle Contraction, Homo sapiens"
xref: Reactome:REACT_29469 "Striated Muscle Contraction, Rattus norvegicus"
xref: Reactome:REACT_31659 "Striated Muscle Contraction, Xenopus tropicalis"
xref: Reactome:REACT_77483 "Striated Muscle Contraction, Taeniopygia guttata"
xref: Reactome:REACT_80658 "Striated Muscle Contraction, Bos taurus"
xref: Reactome:REACT_88644 "Striated Muscle Contraction, Mus musculus"
xref: Reactome:REACT_90913 "Striated Muscle Contraction, Canis familiaris"
xref: Reactome:REACT_97024 "Striated Muscle Contraction, Danio rerio"
xref: Reactome:REACT_97868 "Striated Muscle Contraction, Sus scrofa"
is_a: GO:0033275 ! actin-myosin filament sliding
relationship: part_of GO:0006936 ! muscle contraction

[Term]
id: GO:0030050
name: vesicle transport along actin filament
namespace: biological_process
def: "Movement of a vesicle along an actin filament, mediated by motor proteins." [GOC:mah]
is_a: GO:0030048 ! actin filament-based movement
is_a: GO:0099515 ! actin filament-based transport
is_a: GO:0099518 ! vesicle cytoskeletal trafficking

[Term]
id: GO:0030051
name: obsolete FK506-sensitive peptidyl-prolyl cis-trans isomerase
namespace: molecular_function
def: "OBSOLETE. Interacts selectively with the immunosuppressant FK506, and possesses peptidyl-prolyl isomerase activity (catalysis of the reaction: peptidoproline (omega=180) = peptidylproline (omega=0))." [EC:5.2.1.8, ISBN:0198596732]
comment: This term was made obsolete because it represents a gene product and not a function.
synonym: "FK506 binding protein" RELATED []
synonym: "FK506-sensitive peptidyl-prolyl cis-trans isomerase" EXACT []
synonym: "FKBP" RELATED []
is_obsolete: true
consider: GO:0003755
consider: GO:0005528

[Term]
id: GO:0030052
name: obsolete parvulin
namespace: molecular_function
def: "OBSOLETE. A peptidyl-prolyl isomerase isolated from Escherichia coli. It does not have any function as an immunophilin." [ISBN:0198506732]
comment: This term was made obsolete because it describes a gene product.
synonym: "parvulin" EXACT []
is_obsolete: true
replaced_by: GO:0003755

[Term]
id: GO:0030053
name: obsolete immunophilin
namespace: molecular_function
def: "OBSOLETE. Any member of a family of receptors that includes the major FK506 binding protein FKBP and cyclophilin. These two proteins are unrelated in amino-acid sequence, but both possess peptidyl-prolyl isomerase activity which is blocked by immunosuppressants that block signal-transduction pathways leading to T cell activation such as FK506 and rapamycin, which block FKBP, or cyclosporin A, which blocks cyclophilin." [ISBN:0198506732]
comment: This term was made obsolete because it does not represent a molecular function.
synonym: "immunophilin" EXACT []
is_obsolete: true
consider: GO:0003755
consider: GO:0004872

[Term]
id: GO:0030054
name: cell junction
namespace: cellular_component
def: "A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
xref: Wikipedia:Cell_junction
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0030055
name: cell-substrate junction
namespace: cellular_component
def: "A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:hb, GOC:mah]
synonym: "cell-matrix junction" EXACT []
is_a: GO:0030054 ! cell junction

[Term]
id: GO:0030056
name: hemidesmosome
namespace: cellular_component
def: "A cell-substrate junction (attachment structure) found in epithelial cells that links intermediate filaments to extracellular matrices via transmembrane complexes. In vertebrates, hemidesmosomes mediate contact between the basal side of epithelial cells and the basal lamina. In C. elegans, hemidesmosomes connect epithelial cells to distinct extracellular matrices on both the apical and basal cell surfaces." [GOC:kmv, ISBN:0815316208, PMID:20205195]
synonym: "epidermal attachment structure" NARROW [GOC:kmv]
synonym: "fibrous organelle" NARROW [GOC:kmv, PMID:20205195]
synonym: "hemi-adherens junction" RELATED [http://www.wormatlas.org/glossaries/hglossary.htm#hemiadherensjunction]
synonym: "trans-epithelial attachment" NARROW [GOC:kmv, PMID:20205195]
xref: Wikipedia:Hemidesmosome
is_a: GO:0030055 ! cell-substrate junction

[Term]
id: GO:0030057
name: desmosome
namespace: cellular_component
def: "A cell-cell junction in which: on the cytoplasmic surface of each interacting plasma membrane is a dense plaque composed of a mixture of intracellular anchor proteins; a bundle of keratin intermediate filaments is attached to the surface of each plaque; transmembrane adhesion proteins of the cadherin family bind to the plaques and interact through their extracellular domains to hold the adjacent membranes together by a Ca2+-dependent mechanism." [GOC:mah, GOC:mtg_muscle, ISBN:0815332181]
synonym: "macula adherens" EXACT []
synonym: "spot desmosome" EXACT []
xref: Wikipedia:Desmosome
is_a: GO:0005911 ! cell-cell junction
is_a: GO:0070161 ! anchoring junction

[Term]
id: GO:0030058
name: amine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: R-CH2-NH2 + H2O + acceptor = R-CHO + NH3 + reduced acceptor." [EC:1.4.99.3]
comment: This term represents a transferred EC activity and is scheduled for obsoletion.
subset: mf_needs_review
synonym: "amine: (acceptor) oxidoreductase (deaminating)" EXACT [EC:1.4.99.3]
synonym: "MADH activity" EXACT [EC:1.4.99.3]
synonym: "methylamine dehydrogenase activity" RELATED [EC:1.4.99.3]
synonym: "primary-amine dehydrogenase activity" BROAD [EC:1.4.99.3]
synonym: "primary-amine:(acceptor) oxidoreductase (deaminating)" EXACT [EC:1.4.99.3]
synonym: "primary-amine:acceptor oxidoreductase (deaminating)" EXACT [EC:1.4.99.3]
xref: EC:1.4.99.3
xref: MetaCyc:AMINE-DEHYDROGENASE-RXN
xref: UM-BBD_enzymeID:e0058
is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors

[Term]
id: GO:0030059
name: aralkylamine dehydrogenase (azurin) activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + arCH(2)NH(2) + 2 azurin = 2 reduced azurin + ArCHO + NH(3). The symbol arCH(2)NH(2) represents an aralkylamine and ArCHO is an aryl aldehyde." [EC:1.4.9.2]
synonym: "aralkylamine:(azurin) oxidoreductase (deaminating) activity" EXACT [EC:1.4.9.2]
synonym: "aromatic amine dehydrogenase (azurin) activity" EXACT [EC:1.4.9.2]
synonym: "arylamine dehydrogenase activity" BROAD [EC:1.4.9.2]
synonym: "dehydrogenase, arylamine (azurin) activity" EXACT [EC:1.4.9.2]
synonym: "tyramine dehydrogenase (azurin) activity" NARROW [EC:1.4.9.2]
xref: EC:1.4.9.2
xref: MetaCyc:ARALKYLAMINE-DEHYDROGENASE-RXN
is_a: GO:0052877 ! oxidoreductase activity, acting on the CH-NH2 group of donors, with a copper protein as acceptor

[Term]
id: GO:0030060
name: L-malate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+." [EC:1.1.1.37]
subset: gosubset_prok
synonym: "(S)-malate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.37]
synonym: "L-malate-NAD+ oxidoreductase activity" EXACT [EC:1.1.1.37]
synonym: "malate (NAD) dehydrogenase activity" EXACT [EC:1.1.1.37]
synonym: "malic acid dehydrogenase activity" EXACT [EC:1.1.1.37]
synonym: "malic dehydrogenase activity" EXACT [EC:1.1.1.37]
synonym: "MDH" RELATED [EC:1.1.1.37]
synonym: "NAD-dependent malate dehydrogenase activity" EXACT [EC:1.1.1.37]
synonym: "NAD-dependent malic dehydrogenase activity" EXACT [EC:1.1.1.37]
synonym: "NAD-L-malate dehydrogenase activity" EXACT []
synonym: "NAD-linked malate dehydrogenase activity" EXACT [EC:1.1.1.37]
synonym: "NAD-malate dehydrogenase activity" EXACT [EC:1.1.1.37]
synonym: "NAD-malic dehydrogenase activity" EXACT [EC:1.1.1.37]
synonym: "NAD-specific malate dehydrogenase activity" EXACT [EC:1.1.1.37]
xref: EC:1.1.1.37
xref: MetaCyc:MALATE-DEH-RXN
xref: Reactome:REACT_102397 "malate + NAD+ <=> oxaloacetate + NADH + H+, Gallus gallus"
xref: Reactome:REACT_104572 "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+, Taeniopygia guttata"
xref: Reactome:REACT_105207 "malate + NAD+ <=> oxaloacetate + NADH + H+, Dictyostelium discoideum"
xref: Reactome:REACT_106078 "malate + NAD+ <=> oxaloacetate + NADH + H+, Mycobacterium tuberculosis"
xref: Reactome:REACT_106462 "malate + NAD+ <=> oxaloacetate + NADH + H+, Rattus norvegicus"
xref: Reactome:REACT_106744 "Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+, Canis familiaris"
xref: Reactome:REACT_109070 "malate + NAD+ <=> oxaloacetate + NADH + H+, Sus scrofa"
xref: Reactome:REACT_11169 "Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+, Homo sapiens"
xref: Reactome:REACT_11216 "malate + NAD+ <=> oxaloacetate + NADH + H+, Homo sapiens"
xref: Reactome:REACT_115649 "malate + NAD+ <=> oxaloacetate + NADH + H+, Gallus gallus"
xref: Reactome:REACT_115954 "malate + NAD+ <=> oxaloacetate + NADH + H+, Gallus gallus"
xref: Reactome:REACT_116085 "oxaloacetate + NADH + H+ <=> malate + NAD+, Gallus gallus"
xref: Reactome:REACT_2172 "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+, Homo sapiens"
xref: Reactome:REACT_29462 "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+, Escherichia coli"
xref: Reactome:REACT_31106 "malate + NAD+ <=> oxaloacetate + NADH + H+, Mus musculus"
xref: Reactome:REACT_31242 "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+, Danio rerio"
xref: Reactome:REACT_31405 "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+, Mus musculus"
xref: Reactome:REACT_31952 "malate + NAD+ <=> oxaloacetate + NADH + H+, Xenopus tropicalis"
xref: Reactome:REACT_33338 "Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+, Taeniopygia guttata"
xref: Reactome:REACT_34002 "malate + NAD+ <=> oxaloacetate + NADH + H+, Arabidopsis thaliana"
xref: Reactome:REACT_53903 "Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+, Bos taurus"
xref: Reactome:REACT_77697 "malate + NAD+ <=> oxaloacetate + NADH + H+, Danio rerio"
xref: Reactome:REACT_79868 "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+, Schizosaccharomyces pombe"
xref: Reactome:REACT_80013 "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+, Gallus gallus"
xref: Reactome:REACT_80217 "malate + NAD+ <=> oxaloacetate + NADH + H+, Canis familiaris"
xref: Reactome:REACT_80842 "Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+, Escherichia coli"
xref: Reactome:REACT_80996 "malate + NAD+ <=> oxaloacetate + NADH + H+, Caenorhabditis elegans"
xref: Reactome:REACT_81948 "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+, Rattus norvegicus"
xref: Reactome:REACT_84788 "Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+, Gallus gallus"
xref: Reactome:REACT_86359 "malate + NAD+ <=> oxaloacetate + NADH + H+, Drosophila melanogaster"
xref: Reactome:REACT_87130 "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+, Canis familiaris"
xref: Reactome:REACT_89843 "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+, Bos taurus"
xref: Reactome:REACT_91106 "malate + NAD+ <=> oxaloacetate + NADH + H+, Taeniopygia guttata"
xref: Reactome:REACT_91301 "Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+, Rattus norvegicus"
xref: Reactome:REACT_92377 "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+, Xenopus tropicalis"
xref: Reactome:REACT_94018 "Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+, Danio rerio"
xref: Reactome:REACT_94356 "Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+, Xenopus tropicalis"
xref: Reactome:REACT_95217 "Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+, Drosophila melanogaster"
xref: Reactome:REACT_95270 "malate + NAD+ <=> oxaloacetate + NADH + H+, Oryza sativa"
xref: Reactome:REACT_96050 "malate + NAD+ <=> oxaloacetate + NADH + H+, Bos taurus"
xref: Reactome:REACT_97987 "Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+, Caenorhabditis elegans"
xref: Reactome:REACT_98367 "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+, Caenorhabditis elegans"
xref: Reactome:REACT_98640 "Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+, Mus musculus"
xref: Reactome:REACT_98721 "Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+, Schizosaccharomyces pombe"
xref: Reactome:REACT_99734 "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+, Drosophila melanogaster"
xref: RHEA:21435
is_a: GO:0016615 ! malate dehydrogenase activity
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0030061
name: mitochondrial crista
namespace: cellular_component
def: "Any of the inward folds of the mitochondrial inner membrane. Their number, extent, and shape differ in mitochondria from different tissues and organisms. They appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found. Their shape can vary with the respiratory state of the mitochondria." [ISBN:0198506732]
comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'.
synonym: "cristae" BROAD [NIF_Subcellular:sao333328131]
synonym: "mitochondrial cristae" EXACT []
xref: NIF_Subcellular:sao333328131
is_a: GO:0044455 ! mitochondrial membrane part
relationship: part_of GO:0005743 ! mitochondrial inner membrane

[Term]
id: GO:0030062
name: mitochondrial tricarboxylic acid cycle enzyme complex
namespace: cellular_component
def: "Any of the heteromeric enzymes, located in the mitochondrion, that act in the tricarboxylic acid (TCA) cycle." [GOC:mah, GOC:mtg_sensu]
synonym: "TCA cycle enzyme complex" BROAD []
is_a: GO:0045239 ! tricarboxylic acid cycle enzyme complex
is_a: GO:0098798 ! mitochondrial protein complex
intersection_of: GO:0045239 ! tricarboxylic acid cycle enzyme complex
intersection_of: part_of GO:0005739 ! mitochondrion
relationship: part_of GO:0005739 ! mitochondrion
relationship: part_of GO:0005759 ! mitochondrial matrix

[Term]
id: GO:0030063
name: obsolete murein sacculus
namespace: cellular_component
def: "OBSOLETE. A structure formed of the cross-linked polymer peptidoglycan (also called murein) that forms a covalently closed net around a bacterial cell, and imparts structural stability to the bacterial cell wall." [GOC:mah, PMID:9529891]
comment: This term was made obsolete because it was defined inaccurately.
synonym: "murein sacculus" EXACT []
synonym: "peptidoglycan layer" EXACT []
is_obsolete: true
consider: GO:0009276

[Term]
id: GO:0030064
name: obsolete cell wall inner membrane
namespace: cellular_component
def: "OBSOLETE. The peptidoglycan layer of the cell wall of Gram-negative bacteria." [ISBN:0135712254]
comment: This term was made obsolete because it was defined inaccurately.
synonym: "cell wall inner membrane" EXACT []
is_obsolete: true
consider: GO:0009276

[Term]
id: GO:0030066
name: obsolete cytochrome b6
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "cytochrome b-563" RELATED []
synonym: "cytochrome b6" EXACT []
is_obsolete: true
replaced_by: GO:0045158

[Term]
id: GO:0030067
name: obsolete respiratory chain cytochrome b6
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "respiratory chain cytochrome b6" EXACT []
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0030068
name: obsolete lytic viral life cycle
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because more specific terms were created.
synonym: "lytic viral life cycle" EXACT []
is_obsolete: true
consider: GO:0019058
consider: GO:0044659

[Term]
id: GO:0030070
name: insulin processing
namespace: biological_process
def: "The formation of mature insulin by proteolysis of the precursor preproinsulin. The signal sequence is first cleaved from preproinsulin to form proinsulin; proinsulin is then cleaved to release the C peptide, leaving the A and B chains of mature insulin linked by disulfide bridges." [ISBN:0198506732]
is_a: GO:0016486 ! peptide hormone processing
is_a: GO:1901142 ! insulin metabolic process

[Term]
id: GO:0030071
name: regulation of mitotic metaphase/anaphase transition
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the onset of anaphase (chromosome movement) in the mitotic cell cycle." [GOC:mah]
is_a: GO:0010965 ! regulation of mitotic sister chromatid separation
is_a: GO:1901990 ! regulation of mitotic cell cycle phase transition
is_a: GO:1902099 ! regulation of metaphase/anaphase transition of cell cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007091 ! metaphase/anaphase transition of mitotic cell cycle
relationship: regulates GO:0007091 ! metaphase/anaphase transition of mitotic cell cycle

[Term]
id: GO:0030072
name: peptide hormone secretion
namespace: biological_process
def: "The regulated release of a peptide hormone from a cell." [GOC:mah]
is_a: GO:0002790 ! peptide secretion
is_a: GO:0046879 ! hormone secretion

[Term]
id: GO:0030073
name: insulin secretion
namespace: biological_process
def: "The regulated release of proinsulin from secretory granules (B granules) in the B cells of the pancreas; accompanied by cleavage of proinsulin to form mature insulin." [GOC:mah, ISBN:0198506732]
is_a: GO:0009306 ! protein secretion
is_a: GO:0030072 ! peptide hormone secretion

[Term]
id: GO:0030074
name: obsolete thylakoid (sensu Proteobacteria)
namespace: cellular_component
def: "OBSOLETE. A thylakoid; as in, but not restricted to, the purple bacteria and relatives (Proteobacteria, ncbi_taxonomy_id:1224)." [GOC:mah]
comment: This term was made obsolete because thylakoids are not found in organisms of the Phylum Proteobacteria.
synonym: "thylakoid (sensu Proteobacteria)" EXACT []
is_obsolete: true
consider: GO:0042716

[Term]
id: GO:0030075
name: bacterial thylakoid
namespace: cellular_component
def: "A thylakoid that is derived from and attached to, but not necessarily continuous with, the plasma membrane, and is not enclosed in a plastid. It bears the photosynthetic pigments in photosynthetic cyanobacteria." [GOC:mah, GOC:mtg_sensu]
subset: gosubset_prok
synonym: "plasma membrane-derived thylakoid" EXACT []
is_a: GO:0009579 ! thylakoid
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle

[Term]
id: GO:0030076
name: light-harvesting complex
namespace: cellular_component
def: "A protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center." [GOC:lr]
subset: goslim_pir
subset: gosubset_prok
synonym: "antenna complex" RELATED []
xref: Wikipedia:Light-harvesting_complex
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0030077
name: plasma membrane light-harvesting complex
namespace: cellular_component
def: "A plasma membrane protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. Examples of this complex are found in bacterial species." [GOC:mah, GOC:mtg_sensu]
subset: gosubset_prok
is_a: GO:0030076 ! light-harvesting complex
is_a: GO:0044433 ! cytoplasmic vesicle part
relationship: part_of GO:0042716 ! plasma membrane-derived chromatophore

[Term]
id: GO:0030078
name: light-harvesting complex, core complex
namespace: cellular_component
def: "Light harvesting complex associated with the reaction complex of photosynthetic purple bacteria." [GOC:lr]
subset: gosubset_prok
is_a: GO:0030077 ! plasma membrane light-harvesting complex

[Term]
id: GO:0030079
name: light-harvesting complex, peripheral complex
namespace: cellular_component
def: "Bacteriochlorophyll a binding complex that is peripherally associated to the bacterial reaction center." [GOC:lr]
subset: gosubset_prok
is_a: GO:0030077 ! plasma membrane light-harvesting complex

[Term]
id: GO:0030080
name: B875 antenna complex
namespace: cellular_component
def: "Protein complex that surrounds and transfers excitation energy directly to the bacterial reaction center; binds bacteriochlorophyll a and has a single absorption band between 870 and 890 nm." [GOC:kd]
subset: gosubset_prok
synonym: "LH1 complex" EXACT []
synonym: "light harvesting complex I" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044433 ! cytoplasmic vesicle part
relationship: part_of GO:0030078 ! light-harvesting complex, core complex

[Term]
id: GO:0030081
name: B800-820 antenna complex
namespace: cellular_component
def: "Protein-pigment complex that absorbs light at 800 and 820 nm; is peripherally associated to the bacterial reaction center; transfers excitation energy to the B875 antenna complex." [GOC:kd, GOC:lr]
subset: gosubset_prok
synonym: "LH3 complex" EXACT []
synonym: "light harvesting complex III" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044433 ! cytoplasmic vesicle part
relationship: part_of GO:0030079 ! light-harvesting complex, peripheral complex

[Term]
id: GO:0030082
name: B800-850 antenna complex
namespace: cellular_component
def: "Protein-pigment complex that absorbs light at 800 and 850 nm; is peripherally associated to the bacterial reaction center; transfers excitation energy to the B875 antenna complex." [GOC:kd, GOC:lr]
subset: gosubset_prok
synonym: "LH2 complex" EXACT []
synonym: "light harvesting complex II" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044433 ! cytoplasmic vesicle part
relationship: part_of GO:0030079 ! light-harvesting complex, peripheral complex

[Term]
id: GO:0030083
name: PSI associated light-harvesting complex I, LHCIa subcomplex
namespace: cellular_component
def: "A pigment protein complex that forms part of the photosystem I associated light-harvesting complex I; contains two proteins (usually about 24 and 21.5 kDa); has a fluorescence maximum between 680 and 690 nm." [PMID:8825475]
is_a: GO:0009518 ! PSI associated light-harvesting complex I

[Term]
id: GO:0030084
name: PSI associated light-harvesting complex I, LHCIb subcomplex
namespace: cellular_component
def: "A pigment protein complex that forms part of the photosystem I associated light-harvesting complex I; contains two proteins (usually about 20 kDa); has a fluorescence maximum of 730 nm." [PMID:8825475]
is_a: GO:0009518 ! PSI associated light-harvesting complex I

[Term]
id: GO:0030085
name: PSII associated light-harvesting complex II, peripheral complex, LHCIIb subcomplex
namespace: cellular_component
def: "A pigment protein complex that forms part of the photosystem II associated light-harvesting complex II; contains two proteins (usually about 28 and 27 kDa), and may contain a third; peripherally located relative to other LHC polypeptides." [PMID:8825475]
is_a: GO:0098807 ! chloroplast thylakoid membrane protein complex
relationship: part_of GO:0009656 ! PSII associated light-harvesting complex II, peripheral complex

[Term]
id: GO:0030086
name: obsolete PSII associated light-harvesting complex II, core complex, LHCIIa subcomplex
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because the 'complex' it refers to contains only one gene product.
synonym: "PSII associated light-harvesting complex II, core complex, LHCIIa subcomplex" EXACT []
is_obsolete: true
replaced_by: GO:0009655

[Term]
id: GO:0030087
name: obsolete PSII associated light-harvesting complex II, core complex, LHCIIc subcomplex
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because the 'complex' it refers to contains only one gene product.
synonym: "PSII associated light-harvesting complex II, core complex, LHCIIc subcomplex" EXACT []
is_obsolete: true
replaced_by: GO:0009655

[Term]
id: GO:0030088
name: obsolete PSII associated light-harvesting complex II, core complex, LHCIId subcomplex
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because the 'complex' it refers to contains only one gene product.
synonym: "PSII associated light-harvesting complex II, core complex, LHCIId subcomplex" EXACT []
is_obsolete: true
replaced_by: GO:0009655

[Term]
id: GO:0030089
name: phycobilisome
namespace: cellular_component
def: "Any of the granules, approximately 32 nm x 48 nm and consisting of highly aggregated phycobiliproteins, that are attached in arrays to the external face of a thylakoid membrane in algae of the phyla Cyanophyta and Rhodophyta, where they function as light-harvesting devices in photosynthesis. Excitation energy in the phycobilisome flows in the sequence: phycoerythrin, phycocyanin, allophycocyanin before passing to the antenna chlorophyll of photosystem II." [GOC:jl, PMID:11734882, Wikipedia:Phycobilisome]
subset: gosubset_prok
xref: Wikipedia:Phycobilisome
is_a: GO:0030076 ! light-harvesting complex
is_a: GO:0044436 ! thylakoid part
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0042651 ! thylakoid membrane

[Term]
id: GO:0030091
name: protein repair
namespace: biological_process
def: "The process of restoring a protein to its original state after damage by such things as oxidation or spontaneous decomposition of residues." [GOC:mlg]
subset: gosubset_prok
is_a: GO:0044267 ! cellular protein metabolic process

[Term]
id: GO:0030092
name: obsolete regulation of flagellum assembly
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the formation of a flagellum." [GOC:go_curators]
comment: This term was made obsolete because microtubule-based flagellum (GO:0009434) and motile cilium (GO:0031514), as referenced by this term, were determined to be equivalent and merged. When a merge for this term was considered, it was noticed that both eukaryotic and prokaryotic proteins are annotated to it because its meaning had been ambiguous so obsoletion was considered safest.
synonym: "regulation of flagella assembly" RELATED [GOC:mah]
synonym: "regulation of flagella biogenesis" RELATED []
synonym: "regulation of flagellum assembly" EXACT []
synonym: "regulation of flagellum biogenesis" RELATED [GOC:mah]
is_obsolete: true
consider: GO:1902017
consider: GO:1902208

[Term]
id: GO:0030093
name: chloroplast photosystem I
namespace: cellular_component
def: "Photosystem located in the chloroplast that functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin. An example of this is found in Arabidopsis thaliana." [GOC:jid, GOC:mtg_sensu]
is_a: GO:0009522 ! photosystem I
is_a: GO:0098807 ! chloroplast thylakoid membrane protein complex
intersection_of: GO:0009522 ! photosystem I
intersection_of: part_of GO:0009507 ! chloroplast
relationship: part_of GO:0009507 ! chloroplast
relationship: part_of GO:0009535 ! chloroplast thylakoid membrane

[Term]
id: GO:0030094
name: plasma membrane-derived photosystem I
namespace: cellular_component
def: "A protein complex located in the plasma membrane-derived thylakoid. The photosystem functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin. Examples of this complex are found in bacterial species." [GOC:jid, GOC:mtg_sensu]
subset: gosubset_prok
synonym: "plasma membrane photosystem I" EXACT []
is_a: GO:0009522 ! photosystem I
is_a: GO:0044422 ! organelle part
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0098797 ! plasma membrane protein complex
intersection_of: GO:0009522 ! photosystem I
intersection_of: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0030075 ! bacterial thylakoid

[Term]
id: GO:0030095
name: chloroplast photosystem II
namespace: cellular_component
def: "An integral chloroplast membrane complex containing the P680 reaction center. In the light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone." [GOC:jid, GOC:mtg_sensu]
is_a: GO:0009523 ! photosystem II
is_a: GO:0098807 ! chloroplast thylakoid membrane protein complex
intersection_of: GO:0009523 ! photosystem II
intersection_of: part_of GO:0009507 ! chloroplast
relationship: part_of GO:0009507 ! chloroplast
relationship: part_of GO:0009535 ! chloroplast thylakoid membrane

[Term]
id: GO:0030096
name: plasma membrane-derived thylakoid photosystem II
namespace: cellular_component
def: "A protein complex, located in the membrane-derived thylakoid, containing the P680 reaction center. In the light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone." [GOC:jid, GOC:mtg_sensu]
subset: gosubset_prok
synonym: "plasma membrane photosystem II" EXACT []
is_a: GO:0009523 ! photosystem II
is_a: GO:0044422 ! organelle part
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0098797 ! plasma membrane protein complex
intersection_of: GO:0009523 ! photosystem II
intersection_of: part_of GO:0030075 ! bacterial thylakoid
relationship: part_of GO:0030075 ! bacterial thylakoid

[Term]
id: GO:0030097
name: hemopoiesis
namespace: biological_process
def: "The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732]
synonym: "blood cell biosynthesis" EXACT []
synonym: "blood cell formation" EXACT []
synonym: "haemopoiesis" EXACT []
synonym: "hematopoiesis" EXACT []
xref: Wikipedia:Haematopoiesis
is_a: GO:0048534 ! hematopoietic or lymphoid organ development

[Term]
id: GO:0030098
name: lymphocyte differentiation
namespace: biological_process
alt_id: GO:0046650
def: "The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin." [CL:0000542, GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "lymphocyte cell differentiation" EXACT []
synonym: "lymphocyte development" RELATED [GOC:add]
synonym: "lymphocytic blood cell differentiation" EXACT []
is_a: GO:0002521 ! leukocyte differentiation
is_a: GO:0046649 ! lymphocyte activation

[Term]
id: GO:0030099
name: myeloid cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages." [GOC:add, ISBN:0781735149]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0030097 ! hemopoiesis

[Term]
id: GO:0030100
name: regulation of endocytosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endocytosis." [GOC:go_curators]
is_a: GO:0051128 ! regulation of cellular component organization
is_a: GO:0060627 ! regulation of vesicle-mediated transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006897 ! endocytosis
relationship: regulates GO:0006897 ! endocytosis

[Term]
id: GO:0030101
name: natural killer cell activation
namespace: biological_process
def: "The change in morphology and behavior of a natural killer cell in response to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735140]
synonym: "NK cell activation" EXACT []
is_a: GO:0046649 ! lymphocyte activation

[Term]
id: GO:0030103
name: vasopressin secretion
namespace: biological_process
def: "The regulated release of vasopressin from secretory granules into the blood." [GOC:mah]
is_a: GO:0030072 ! peptide hormone secretion

[Term]
id: GO:0030104
name: water homeostasis
namespace: biological_process
alt_id: GO:0018987
def: "Any process involved in the maintenance of an internal steady state of water within an organism or cell." [GOC:dph, GOC:mah, GOC:tb]
synonym: "osmoregulation" RELATED []
synonym: "regulation of osmotic pressure" EXACT []
xref: Wikipedia:Osmoregulation
is_a: GO:0048878 ! chemical homeostasis

[Term]
id: GO:0030105
name: obsolete anaphylaxis
namespace: biological_process
def: "OBSOLETE. Extreme immunological sensitivity of the body or tissues to the reintroduction of an antigen. It is a form of anamnestic reaction and is accompanied by pathological changes in tissues or organs due to the release of pharmacologically active substances." [ISBN:0198506732]
comment: This term was made obsolete because it represents a an abnormal process that is harmful to the organism.
synonym: "anaphylaxis" EXACT []
is_obsolete: true
consider: GO:0006955

[Term]
id: GO:0030106
name: obsolete MHC class I receptor activity
namespace: molecular_function
def: "OBSOLETE. A major histocompatibility complex class I receptor. These display processed antigens from the endocytosed bacteria. MHC class I proteins can form complexes with processed antigen peptides only if the antigen is synthesized in the same cell. As a consequence, T lymphocytes can only bind to class-I-positive cells that are synthesizing the antigen (e.g. virus-infected cells)." [ISBN:081533642X, ISBN:0879694971]
comment: This term was made obsolete because the definition is ambiguous and contains incorrect information. To update annotations of gene products that act as receptors for MHC class I protein complexes, use the molecular function term 'MHC class I receptor activity ; GO:0032393'; to update annotations of gene products which are components of MHC class I protein complexes, use the cellular component term 'MHC class I protein complex ; GO:0042612'.
synonym: "class I major histocompatibility complex antigen" RELATED []
synonym: "major histocompatibility complex class I receptor" EXACT []
synonym: "MHC class I receptor activity" EXACT []
is_obsolete: true
consider: GO:0032393
consider: GO:0042612

[Term]
id: GO:0030107
name: HLA-A specific inhibitory MHC class I receptor activity
namespace: molecular_function
def: "Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that inhibits activation of a lymphocyte." [GOC:add, GOC:mah, PMID:11929129, PMID:9368779]
is_a: GO:0032396 ! inhibitory MHC class I receptor activity

[Term]
id: GO:0030108
name: HLA-A specific activating MHC class I receptor activity
namespace: molecular_function
def: "Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that activates a lymphocyte." [GOC:add, GOC:mah, PMID:11929129, PMID:9368779]
is_a: GO:0032397 ! activating MHC class I receptor activity

[Term]
id: GO:0030109
name: HLA-B specific inhibitory MHC class I receptor activity
namespace: molecular_function
def: "Combining with a MHC class I molecule of the HLA-B subclass to mediate signaling that inhibits activation of a lymphocyte." [GOC:add, GOC:mah, PMID:11929129, PMID:9368779]
is_a: GO:0032396 ! inhibitory MHC class I receptor activity

[Term]
id: GO:0030110
name: HLA-C specific inhibitory MHC class I receptor activity
namespace: molecular_function
def: "Combining with a MHC class I molecule of the HLA-C subclass to mediate signaling that inhibits activation of a lymphocyte." [GOC:add, GOC:mah, PMID:11929129, PMID:9368779]
is_a: GO:0032396 ! inhibitory MHC class I receptor activity

[Term]
id: GO:0030111
name: regulation of Wnt signaling pathway
namespace: biological_process
alt_id: GO:0008590
def: "Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway." [GOC:dph, GOC:mah, GOC:tb]
synonym: "regulation of frizzled signaling pathway" EXACT []
synonym: "regulation of frizzled signalling pathway" EXACT []
synonym: "regulation of Wnt receptor signaling pathway" EXACT []
synonym: "regulation of Wnt receptor signalling pathway" EXACT []
synonym: "regulation of Wnt-activated signaling pathway" EXACT [GOC:signaling]
is_a: GO:0009966 ! regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016055 ! Wnt signaling pathway
relationship: regulates GO:0016055 ! Wnt signaling pathway

[Term]
id: GO:0030112
name: glycocalyx
namespace: cellular_component
def: "A viscous, carbohydrate rich layer at the outermost periphery of a cell." [GOC:mlg, ISBN:0815316208]
subset: goslim_pir
subset: gosubset_prok
xref: Wikipedia:Glycocalyx
is_a: GO:0030312 ! external encapsulating structure

[Term]
id: GO:0030114
name: slime layer
namespace: cellular_component
def: "A slime layer is an easily removed, diffuse, unorganized layer of extracellular material that surrounds a cell. Specifically this consists mostly of exopolysaccharides, glycoproteins, and glycolipids." [GOC:mlg, Wikipedia:Slime_layer]
xref: Wikipedia:Slime_layer
is_a: GO:0030112 ! glycocalyx

[Term]
id: GO:0030115
name: S-layer
namespace: cellular_component
def: "A crystalline protein layer surrounding some bacteria." [GOC:mlg, ISBN:0815108893]
subset: goslim_pir
subset: gosubset_prok
xref: Wikipedia:S-layer
is_a: GO:0030312 ! external encapsulating structure

[Term]
id: GO:0030116
name: glial cell-derived neurotrophic factor receptor binding
namespace: molecular_function
def: "A growth factor that binds selectively and non-covalently to glial cell-derived neurotrophic factor receptors." [GOC:vw, PMID:11476867]
synonym: "glial cell line-derived neurotrophic factor receptor binding" RELATED []
synonym: "glial cell line-derived neurotrophic factor receptor ligand" NARROW []
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0030117
name: membrane coat
namespace: cellular_component
def: "Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah]
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0048475 ! coated membrane

[Term]
id: GO:0030118
name: clathrin coat
namespace: cellular_component
alt_id: GO:0016190
def: "A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes." [GOC:mah, PMID:11252894, PMID:9531549]
synonym: "clathrin cage" EXACT []
xref: NIF_Subcellular:sao879919129
xref: Wikipedia:Clathrin
is_a: GO:0030117 ! membrane coat

[Term]
id: GO:0030119
name: AP-type membrane coat adaptor complex
namespace: cellular_component
def: "Any of several heterotetrameric complexes that link clathrin (or another coat-forming molecule, as hypothesized for AP-3 and AP-4) to a membrane surface; they are found on coated pits and coated vesicles, and mediate sorting of cargo proteins into vesicles. Each AP complex contains two large (a beta and one of either an alpha, gamma, delta, or epsilon) subunits (110-130 kDa), a medium (mu) subunit (approximately 50 kDa), and a small (sigma) subunit (15-20 kDa)." [GOC:mah, PMID:10611976, PMID:15473838]
subset: goslim_pir
synonym: "clathrin adaptor" RELATED []
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0030117 ! membrane coat

[Term]
id: GO:0030120
name: vesicle coat
namespace: cellular_component
def: "A membrane coat found on a coated vesicle." [GOC:mah]
xref: NIF_Subcellular:sao1177708494
is_a: GO:0030117 ! membrane coat
is_a: GO:0044433 ! cytoplasmic vesicle part
relationship: part_of GO:0030662 ! coated vesicle membrane

[Term]
id: GO:0030121
name: AP-1 adaptor complex
namespace: cellular_component
def: "A heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-1-containing coats are normally found primarily in the trans-Golgi network. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C)." [GOC:mah, PMID:10611976, PMID:21097499]
synonym: "HA1" EXACT []
synonym: "HA1 clathrin adaptor" EXACT []
is_a: GO:0030131 ! clathrin adaptor complex
is_a: GO:0044431 ! Golgi apparatus part
is_a: GO:0044433 ! cytoplasmic vesicle part
relationship: part_of GO:0030130 ! clathrin coat of trans-Golgi network vesicle

[Term]
id: GO:0030122
name: AP-2 adaptor complex
namespace: cellular_component
def: "A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC)." [GOC:mah, PMID:10611976, PMID:21097499]
synonym: "HA2" EXACT []
synonym: "HA2 clathrin adaptor" EXACT []
is_a: GO:0030131 ! clathrin adaptor complex
is_a: GO:0044433 ! cytoplasmic vesicle part
is_a: GO:0098797 ! plasma membrane protein complex
relationship: part_of GO:0030128 ! clathrin coat of endocytic vesicle
relationship: part_of GO:0030132 ! clathrin coat of coated pit

[Term]
id: GO:0030123
name: AP-3 adaptor complex
namespace: cellular_component
def: "A heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. AP-3 does not appear to associate with clathrin in all organisms. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B)." [GOC:mah, PMID:10611976, PMID:21097499]
is_a: GO:0030119 ! AP-type membrane coat adaptor complex

[Term]
id: GO:0030124
name: AP-4 adaptor complex
namespace: cellular_component
def: "An AP-type membrane coat adaptor complex that consists of beta4, epsilon, mu4 and sigma4 subunits and is found associated with membranes in the trans-Golgi network; it is not clear whether AP-4 forms clathrin coats in vivo." [GOC:mah, PMID:10611976]
is_a: GO:0030119 ! AP-type membrane coat adaptor complex

[Term]
id: GO:0030125
name: clathrin vesicle coat
namespace: cellular_component
def: "A clathrin coat found on a vesicle." [GOC:mah]
is_a: GO:0030118 ! clathrin coat
is_a: GO:0030120 ! vesicle coat
relationship: part_of GO:0030665 ! clathrin-coated vesicle membrane

[Term]
id: GO:0030126
name: COPI vesicle coat
namespace: cellular_component
alt_id: GO:0017167
def: "One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state." [GOC:mah, PMID:11252894]
synonym: "coatomer" EXACT []
is_a: GO:0030120 ! vesicle coat
is_a: GO:0044431 ! Golgi apparatus part
relationship: part_of GO:0030663 ! COPI-coated vesicle membrane

[Term]
id: GO:0030127
name: COPII vesicle coat
namespace: cellular_component
def: "One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state." [GOC:ascb_2009, GOC:dph, GOC:mah, GOC:tb, PMID:11252894]
is_a: GO:0030120 ! vesicle coat
relationship: part_of GO:0012507 ! ER to Golgi transport vesicle membrane

[Term]
id: GO:0030128
name: clathrin coat of endocytic vesicle
namespace: cellular_component
def: "A clathrin coat found on an endocytic vesicle." [GOC:mah]
synonym: "clathrin coat of endocytotic vesicle" EXACT []
is_a: GO:0030125 ! clathrin vesicle coat
intersection_of: GO:0030118 ! clathrin coat
intersection_of: part_of GO:0030139 ! endocytic vesicle
relationship: part_of GO:0030139 ! endocytic vesicle
relationship: part_of GO:0030669 ! clathrin-coated endocytic vesicle membrane

[Term]
id: GO:0030129
name: clathrin coat of synaptic vesicle
namespace: cellular_component
def: "A clathrin coat found on a synaptic vesicle." [GOC:mah]
subset: goslim_synapse
is_a: GO:0030125 ! clathrin vesicle coat
is_a: GO:0044456 ! synapse part
is_a: GO:0097458 ! neuron part
intersection_of: GO:0030118 ! clathrin coat
intersection_of: part_of GO:0008021 ! synaptic vesicle
relationship: part_of GO:0008021 ! synaptic vesicle
relationship: part_of GO:0030672 ! synaptic vesicle membrane

[Term]
id: GO:0030130
name: clathrin coat of trans-Golgi network vesicle
namespace: cellular_component
def: "A clathrin coat found on a vesicle of the trans-Golgi network." [GOC:mah]
synonym: "clathrin coat of TGN vesicle" EXACT []
is_a: GO:0030125 ! clathrin vesicle coat
is_a: GO:0044431 ! Golgi apparatus part
relationship: part_of GO:0012510 ! trans-Golgi network transport vesicle membrane

[Term]
id: GO:0030131
name: clathrin adaptor complex
namespace: cellular_component
def: "A membrane coat adaptor complex that links clathrin to a membrane." [GOC:mah]
is_a: GO:0030119 ! AP-type membrane coat adaptor complex
relationship: part_of GO:0030118 ! clathrin coat

[Term]
id: GO:0030132
name: clathrin coat of coated pit
namespace: cellular_component
def: "The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex." [GOC:mah]
is_a: GO:0030118 ! clathrin coat
is_a: GO:0098797 ! plasma membrane protein complex
intersection_of: GO:0030118 ! clathrin coat
intersection_of: part_of GO:0005905 ! coated pit
relationship: part_of GO:0005905 ! coated pit

[Term]
id: GO:0030133
name: transport vesicle
namespace: cellular_component
def: "Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell." [GOC:mah, PMID:22160157]
comment: Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'secretory granule ; GO:0030141'.
synonym: "constitutive secretory pathway transport vesicle" EXACT []
synonym: "Golgi to vacuole transport vesicle" NARROW []
synonym: "Golgi-vacuole transport vesicle" NARROW []
synonym: "secretory vesicle" RELATED []
xref: NIF_Subcellular:sao885490876
is_a: GO:0016023 ! cytoplasmic, membrane-bounded vesicle
relationship: part_of GO:0012505 ! endomembrane system

[Term]
id: GO:0030134
name: ER to Golgi transport vesicle
namespace: cellular_component
alt_id: GO:0030138
def: "A vesicle that mediates transport from the endoplasmic reticulum to the Golgi complex; bears a coat formed of the COPII coat complex proteins; such vesicles found associated with endoplasmic reticulum (ER) membranes at steady state, and are involved in ER to Golgi (anterograde) vesicle transport." [GOC:ascb_2009, GOC:dph, GOC:mah, GOC:tb, PMID:11252894]
synonym: "COPII vesicle" RELATED []
synonym: "COPII-coated vesicle" EXACT []
synonym: "endoplasmic reticulum to Golgi transport vesicle" EXACT []
synonym: "endoplasmic reticulum-Golgi transport vesicle" EXACT []
synonym: "ER to Golgi constitutive secretory pathway transport vesicle" EXACT []
synonym: "ER-Golgi transport vesicle" EXACT []
is_a: GO:0030133 ! transport vesicle
is_a: GO:0030135 ! coated vesicle

[Term]
id: GO:0030135
name: coated vesicle
namespace: cellular_component
alt_id: GO:0005909
def: "Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins." [ISBN:0815316194]
xref: NIF_Subcellular:sao1985096626
is_a: GO:0016023 ! cytoplasmic, membrane-bounded vesicle

[Term]
id: GO:0030136
name: clathrin-coated vesicle
namespace: cellular_component
def: "A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes." [GOC:mah, PMID:11252894]
xref: NIF_Subcellular:sao148845161
is_a: GO:0030135 ! coated vesicle

[Term]
id: GO:0030137
name: COPI-coated vesicle
namespace: cellular_component
def: "A vesicle with a coat formed of the COPI coat complex proteins. COPI-coated vesicles are found associated with Golgi membranes at steady state, are involved in Golgi to endoplasmic reticulum (retrograde) vesicle transport, and possibly also in intra-Golgi transport." [GOC:mah, PMID:11252894]
synonym: "coatomer" RELATED []
is_a: GO:0005798 ! Golgi-associated vesicle
is_a: GO:0030135 ! coated vesicle

[Term]
id: GO:0030139
name: endocytic vesicle
namespace: cellular_component
def: "A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting." [GOC:go_curators, PMID:19696797]
subset: gosubset_prok
synonym: "endocytotic transport vesicle" EXACT []
synonym: "endocytotic vesicle" EXACT []
xref: NIF_Subcellular:sao1362520468
is_a: GO:0016023 ! cytoplasmic, membrane-bounded vesicle

[Term]
id: GO:0030140
name: trans-Golgi network transport vesicle
namespace: cellular_component
def: "A vesicle that mediates transport between the trans-Golgi network and other parts of the cell." [GOC:mah]
synonym: "TGN transport vesicle" EXACT []
synonym: "trans-Golgi network constitutive secretory pathway transport vesicle" EXACT []
is_a: GO:0005798 ! Golgi-associated vesicle
is_a: GO:0030133 ! transport vesicle
is_a: GO:0030136 ! clathrin-coated vesicle

[Term]
id: GO:0030141
name: secretory granule
namespace: cellular_component
def: "A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198596732]
comment: Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'transport vesicle ; GO:0030133'.
synonym: "secretory vesicle" BROAD []
is_a: GO:0099503 ! secretory vesicle
relationship: part_of GO:0012505 ! endomembrane system

[Term]
id: GO:0030142
name: Golgi to ER transport vesicle
namespace: cellular_component
def: "A vesicle that mediates transport from the Golgi to the endoplasmic reticulum." [GOC:mah, PMID:22160157]
synonym: "Golgi to endoplasmic reticulum transport vesicle" EXACT []
synonym: "Golgi to ER constitutive secretory pathway transport vesicle" EXACT []
synonym: "Golgi-endoplasmic reticulum transport vesicle" EXACT []
synonym: "Golgi-ER transport vesicle" EXACT []
synonym: "retrograde transport vesicle" EXACT [PMID:22160157]
is_a: GO:0030133 ! transport vesicle
is_a: GO:0030137 ! COPI-coated vesicle

[Term]
id: GO:0030143
name: inter-Golgi transport vesicle
namespace: cellular_component
alt_id: GO:0005807
def: "A vesicle that mediates transport of cargo within the Golgi complex (for example, between cisternae of the Golgi stack)." [GOC:mah]
synonym: "inter-Golgi transport constitutive secretory pathway transport vesicle" EXACT []
xref: NIF_Subcellular:sao1382918459
is_a: GO:0030133 ! transport vesicle
is_a: GO:0030137 ! COPI-coated vesicle

[Term]
id: GO:0030144
name: alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl,1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-(N-acetyl-beta-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R. Only branched mannose glycopeptides with non-reducing N-acetylglucosamine terminal residues act as acceptors." [EC:2.4.1.155]
synonym: "alpha-1,3(6)-mannosylglycoprotein beta-1,6-N-acetylglucosaminyltransferase activity" EXACT []
synonym: "alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity" EXACT []
synonym: "alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.155]
synonym: "GnTV activity" EXACT [EC:2.4.1.155]
synonym: "N-acetylglucosaminyltransferase V activity" RELATED [EC:2.4.1.155]
synonym: "UDP-N-acetyl-D-glucosamine:6-[2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl]-glycoprotein 6-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.155]
synonym: "UDP-N-acetylglucosamine:alpha-mannoside-beta-1,6 N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.155]
synonym: "UDP-N-acetylglucosamine:alpha-mannoside-beta1,6 N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.155]
synonym: "uridine diphosphoacetylglucosamine-alpha-mannoside beta-1->6-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.155]
synonym: "uridine diphosphoacetylglucosamine-alpha-mannoside beta1->6-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.155]
xref: EC:2.4.1.155
xref: MetaCyc:2.4.1.155-RXN
xref: Reactome:REACT_25314 "Addition of GlcNAc to position 5 by MGAT5, Homo sapiens"
xref: RHEA:16924
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0030145
name: manganese ion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with manganese (Mn) ions." [GOC:ai]
subset: gosubset_prok
synonym: "manganese binding" EXACT []
is_a: GO:0046914 ! transition metal ion binding

[Term]
id: GO:0030146
name: obsolete diuresis
namespace: biological_process
alt_id: GO:0003076
def: "OBSOLETE. The process of renal water excretion." [GOC:mah, GOC:mtg_cardio, ISBN:0198506732]
comment: This term was made obsolete because its definition was inaccurate.
synonym: "diuresis" EXACT []
synonym: "positive regulation of renal water excretion" EXACT []
synonym: "renal water excretion" BROAD []
xref: Wikipedia:Diuresis
is_obsolete: true
consider: GO:0035810

[Term]
id: GO:0030147
name: obsolete natriuresis
namespace: biological_process
def: "OBSOLETE. The process of renal sodium excretion." [GOC:mtg_cardio, ISBN:0198506732]
comment: This term was made obsolete because its definition was inaccurate.
synonym: "natriuresis" EXACT []
xref: Wikipedia:Natriuresis
is_obsolete: true
consider: GO:0035815

[Term]
id: GO:0030148
name: sphingolipid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732]
subset: gosubset_prok
synonym: "sphingolipid anabolism" EXACT []
synonym: "sphingolipid biosynthesis" EXACT []
synonym: "sphingolipid formation" EXACT []
synonym: "sphingolipid synthesis" EXACT []
xref: MetaCyc:PWY-5129
xref: Reactome:REACT_115810 "Sphingolipid de novo biosynthesis, Homo sapiens"
xref: Reactome:REACT_118067 "Sphingolipid de novo biosynthesis, Saccharomyces cerevisiae"
xref: Reactome:REACT_118077 "Sphingolipid de novo biosynthesis, Caenorhabditis elegans"
xref: Reactome:REACT_118168 "Sphingolipid de novo biosynthesis, Escherichia coli"
xref: Reactome:REACT_118187 "Sphingolipid de novo biosynthesis, Mus musculus"
xref: Reactome:REACT_118195 "Sphingolipid de novo biosynthesis, Oryza sativa"
xref: Reactome:REACT_118212 "Sphingolipid de novo biosynthesis, Drosophila melanogaster"
xref: Reactome:REACT_118230 "Sphingolipid de novo biosynthesis, Xenopus tropicalis"
xref: Reactome:REACT_118262 "Sphingolipid de novo biosynthesis, Rattus norvegicus"
xref: Reactome:REACT_118308 "Sphingolipid de novo biosynthesis, Bos taurus"
xref: Reactome:REACT_118369 "Sphingolipid de novo biosynthesis, Sus scrofa"
xref: Reactome:REACT_118378 "Sphingolipid de novo biosynthesis, Taeniopygia guttata"
xref: Reactome:REACT_118382 "Sphingolipid de novo biosynthesis, Schizosaccharomyces pombe"
xref: Reactome:REACT_118387 "Sphingolipid de novo biosynthesis, Canis familiaris"
xref: Reactome:REACT_118398 "Sphingolipid de novo biosynthesis, Danio rerio"
xref: Reactome:REACT_118447 "Sphingolipid de novo biosynthesis, Plasmodium falciparum"
xref: Reactome:REACT_118477 "Sphingolipid de novo biosynthesis, Gallus gallus"
xref: Reactome:REACT_118493 "Sphingolipid de novo biosynthesis, Dictyostelium discoideum"
xref: Reactome:REACT_118525 "Sphingolipid de novo biosynthesis, Mycobacterium tuberculosis"
xref: Reactome:REACT_118535 "Sphingolipid de novo biosynthesis, Arabidopsis thaliana"
is_a: GO:0006665 ! sphingolipid metabolic process
is_a: GO:0046467 ! membrane lipid biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process

[Term]
id: GO:0030149
name: sphingolipid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732]
subset: gosubset_prok
synonym: "sphingolipid breakdown" EXACT []
synonym: "sphingolipid catabolism" EXACT []
synonym: "sphingolipid degradation" EXACT []
is_a: GO:0006665 ! sphingolipid metabolic process
is_a: GO:0046466 ! membrane lipid catabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process

[Term]
id: GO:0030150
name: protein import into mitochondrial matrix
namespace: biological_process
def: "The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together." [ISBN:0716731363]
synonym: "mitochondrial matrix protein import" EXACT []
synonym: "mitochondrial translocation" BROAD []
synonym: "protein transport into mitochondrial matrix" EXACT []
is_a: GO:0044743 ! intracellular protein transmembrane import
is_a: GO:0070585 ! protein localization to mitochondrion
is_a: GO:0072655 ! establishment of protein localization to mitochondrion
is_a: GO:1902580 ! single-organism cellular localization
is_a: GO:1990542 ! mitochondrial transmembrane transport
relationship: occurs_in GO:0005737 ! cytoplasm
relationship: part_of GO:0006626 ! protein targeting to mitochondrion

[Term]
id: GO:0030151
name: molybdenum ion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with molybdenum (Mo) ions." [GOC:ai]
subset: gosubset_prok
synonym: "molybdenum binding" EXACT []
is_a: GO:0046914 ! transition metal ion binding

[Term]
id: GO:0030152
name: bacteriocin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a bacteriocin, any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary." [GOC:mah, ISBN:0198506732]
subset: gosubset_prok
synonym: "bacteriocin anabolism" EXACT []
synonym: "bacteriocin biosynthesis" EXACT []
synonym: "bacteriocin formation" EXACT []
synonym: "bacteriocin synthesis" EXACT []
is_a: GO:0009403 ! toxin biosynthetic process
is_a: GO:0030651 ! peptide antibiotic biosynthetic process
is_a: GO:0046224 ! bacteriocin metabolic process

[Term]
id: GO:0030153
name: bacteriocin immunity
namespace: biological_process
def: "A process that mediates resistance to a bacteriocin: any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary." [GOC:mah, ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0009404 ! toxin metabolic process

[Term]
id: GO:0030154
name: cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_plant
subset: gosubset_prok
xref: Wikipedia:Cellular_differentiation
is_a: GO:0048869 ! cellular developmental process

[Term]
id: GO:0030155
name: regulation of cell adhesion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix." [GOC:mah]
subset: gosubset_prok
synonym: "cell adhesion receptor regulator activity" RELATED []
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007155 ! cell adhesion
relationship: regulates GO:0007155 ! cell adhesion

[Term]
id: GO:0030156
name: benzodiazepine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the peripheral benzodiazepine receptor (PBR)." [GOC:ceb, GOC:mah, PMID:9915832]
synonym: "benzodiazepine receptor ligand" NARROW []
synonym: "diazepam binding inhibitor activity" RELATED []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0030157
name: pancreatic juice secretion
namespace: biological_process
def: "The regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine. Pancreatic juice is slightly alkaline and contains numerous enzymes and inactive enzyme precursors including alpha-amylase, chymotrypsinogen, lipase, procarboxypeptidase, proelastase, prophospholipase A2, ribonuclease, and trypsinogen. Its high concentration of bicarbonate ions helps to neutralize the acid from the stomach." [GOC:mah, ISBN:0198506732]
is_a: GO:0007589 ! body fluid secretion
is_a: GO:0022600 ! digestive system process
is_a: GO:0032941 ! secretion by tissue

[Term]
id: GO:0030158
name: protein xylosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a beta-D-xylosyl residue from UDP-D-xylose to the serine hydroxyl group of an acceptor protein substrate." [EC:2.4.2.26]
synonym: "peptide O-xylosyltransferase activity" EXACT []
synonym: "UDP-D-xylose:core protein beta-D-xylosyltransferase activity" EXACT [EC:2.4.2.26]
synonym: "UDP-D-xylose:core protein xylosyltransferase activity" EXACT [EC:2.4.2.26]
synonym: "UDP-D-xylose:protein beta-D-xylosyltransferase activity" EXACT [EC:2.4.2.26]
synonym: "UDP-D-xylose:proteoglycan core protein beta-D-xylosyltransferase activity" EXACT [EC:2.4.2.26]
synonym: "UDP-xylose-core protein beta-D-xylosyltransferase activity" EXACT [EC:2.4.2.26]
synonym: "uridine diphosphoxylose-core protein beta-xylosyltransferase activity" EXACT [EC:2.4.2.26]
synonym: "uridine diphosphoxylose-protein xylosyltransferase activity" EXACT [EC:2.4.2.26]
xref: EC:2.4.2.26
xref: MetaCyc:2.4.2.26-RXN
is_a: GO:0035252 ! UDP-xylosyltransferase activity

[Term]
id: GO:0030159
name: receptor signaling complex scaffold activity
namespace: molecular_function
def: "Functions to provide a physical support for the assembly of a multiprotein receptor signaling complex." [GOC:mah]
synonym: "receptor signaling complex scaffold protein activity" EXACT []
synonym: "receptor signalling complex scaffold activity" EXACT []
is_a: GO:0032947 ! protein complex scaffold

[Term]
id: GO:0030160
name: GKAP/Homer scaffold activity
namespace: molecular_function
def: "Functions as a physical support bridging the N-methyl-D-aspartate receptor-PSD-95-GKAP complex and the mGluR-Homer complex, which are involved in receptor signaling in synapses." [PMID:10506216]
synonym: "GKAP/Homer scaffold protein" NARROW []
synonym: "postsynaptic density scaffold protein" NARROW []
is_a: GO:0030159 ! receptor signaling complex scaffold activity

[Term]
id: GO:0030161
name: obsolete calpain inhibitor activity
namespace: molecular_function
def: "OBSOLETE. Stops, prevents or reduces the activity of the enzyme calpain, which catalyzes of the preferential cleavage of Tyr-Xaa, Met-Xaa or Arg-Xaa with Leu or Val as the P2 residue." [GOC:ai]
comment: This term was made obsolete because it represents a regulator of a non-existent molecular function.
synonym: "calpain inhibitor activity" EXACT []
is_obsolete: true
replaced_by: GO:0010859

[Term]
id: GO:0030162
name: regulation of proteolysis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of peptidolysis" EXACT []
is_a: GO:0051246 ! regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006508 ! proteolysis
relationship: regulates GO:0006508 ! proteolysis

[Term]
id: GO:0030163
name: protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah]
comment: This term refers to the breakdown of mature proteins. For cleavage events involved in generating a mature protein from a precursor, consider instead the term 'protein maturation ; GO:0051604' and its children.
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_pombe
subset: gosubset_prok
synonym: "pheromone catabolic process" RELATED []
synonym: "pheromone catabolism" RELATED []
synonym: "protein breakdown" EXACT []
synonym: "protein catabolism" EXACT []
synonym: "protein degradation" EXACT []
xref: Wikipedia:Protein_catabolism
is_a: GO:0009057 ! macromolecule catabolic process
is_a: GO:0019538 ! protein metabolic process

[Term]
id: GO:0030164
name: protein denaturation
namespace: biological_process
def: "Structural change in proteins which destroys the native, active configuration without rupture of peptide bonds." [GOC:kd, ISBN:3110145359]
subset: gosubset_prok
xref: Wikipedia:Denaturation#Protein_denaturation
is_a: GO:0044257 ! cellular protein catabolic process

[Term]
id: GO:0030165
name: PDZ domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins." [GOC:go_curators, Pfam:PF00595]
synonym: "DHR-domain binding" EXACT []
synonym: "GLGF-domain binding" EXACT []
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0030166
name: proteoglycan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [GOC:mah, ISBN:0198506732]
subset: gosubset_prok
synonym: "proteoglycan anabolism" EXACT []
synonym: "proteoglycan biosynthesis" EXACT []
synonym: "proteoglycan formation" EXACT []
synonym: "proteoglycan synthesis" EXACT []
is_a: GO:0006029 ! proteoglycan metabolic process
is_a: GO:0009101 ! glycoprotein biosynthetic process

[Term]
id: GO:0030167
name: proteoglycan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [GOC:mah, ISBN:0198506732]
subset: gosubset_prok
synonym: "proteoglycan breakdown" EXACT []
synonym: "proteoglycan catabolism" EXACT []
synonym: "proteoglycan degradation" EXACT []
is_a: GO:0006029 ! proteoglycan metabolic process
is_a: GO:0006516 ! glycoprotein catabolic process

[Term]
id: GO:0030168
name: platelet activation
namespace: biological_process
def: "A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug." [http://www.graylab.ac.uk/omd/]
synonym: "blood coagulation, platelet activation" EXACT [GOC:add, GOC:pde]
xref: Reactome:REACT_103583 "Platelet activation, signaling and aggregation, Mus musculus"
xref: Reactome:REACT_105599 "Platelet activation, signaling and aggregation, Danio rerio"
xref: Reactome:REACT_108920 "Platelet activation, signaling and aggregation, Saccharomyces cerevisiae"
xref: Reactome:REACT_109042 "Platelet activation, signaling and aggregation, Arabidopsis thaliana"
xref: Reactome:REACT_118465 "Platelet activation, signaling and aggregation, Escherichia coli"
xref: Reactome:REACT_28166 "Platelet activation, signaling and aggregation, Rattus norvegicus"
xref: Reactome:REACT_29092 "Platelet activation, signaling and aggregation, Caenorhabditis elegans"
xref: Reactome:REACT_29357 "Platelet activation, signaling and aggregation, Staphylococcus aureus N315"
xref: Reactome:REACT_32211 "Platelet activation, signaling and aggregation, Bos taurus"
xref: Reactome:REACT_798 "Platelet activation, signaling and aggregation, Homo sapiens"
xref: Reactome:REACT_82375 "Platelet activation, signaling and aggregation, Sus scrofa"
xref: Reactome:REACT_82964 "Platelet activation, signaling and aggregation, Mycobacterium tuberculosis"
xref: Reactome:REACT_83720 "Platelet activation, signaling and aggregation, Dictyostelium discoideum"
xref: Reactome:REACT_85922 "Platelet activation, signaling and aggregation, Canis familiaris"
xref: Reactome:REACT_86767 "Platelet activation, signaling and aggregation, Taeniopygia guttata"
xref: Reactome:REACT_86968 "Platelet activation, signaling and aggregation, Xenopus tropicalis"
xref: Reactome:REACT_88667 "Platelet activation, signaling and aggregation, Drosophila melanogaster"
xref: Reactome:REACT_88938 "Platelet activation, signaling and aggregation, Gallus gallus"
xref: Reactome:REACT_92635 "Platelet activation, signaling and aggregation, Oryza sativa"
xref: Reactome:REACT_96250 "Platelet activation, signaling and aggregation, Schizosaccharomyces pombe"
xref: Reactome:REACT_97013 "Platelet activation, signaling and aggregation, Plasmodium falciparum"
is_a: GO:0001775 ! cell activation
relationship: part_of GO:0007596 ! blood coagulation

[Term]
id: GO:0030169
name: low-density lipoprotein particle binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a low-density lipoprotein particle, a lipoprotein particle that is rich in cholesterol esters and low in triglycerides, is typically composed of APOB100 and APOE, and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm." [GOC:mah]
subset: goslim_chembl
synonym: "LDL binding" EXACT []
is_a: GO:0071813 ! lipoprotein particle binding

[Term]
id: GO:0030170
name: pyridoxal phosphate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0043168 ! anion binding
is_a: GO:0048037 ! cofactor binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding

[Term]
id: GO:0030171
name: voltage-gated proton channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a proton by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [ISBN:10615049]
synonym: "voltage gated proton channel activity" EXACT []
synonym: "voltage-dependent proton channel activity" EXACT []
is_a: GO:0015252 ! hydrogen ion channel activity
is_a: GO:0022843 ! voltage-gated cation channel activity

[Term]
id: GO:0030172
name: troponin C binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with troponin C, the calcium-binding subunit of the troponin complex." [GOC:mah, ISBN:0815316194]
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0030173
name: integral component of Golgi membrane
namespace: cellular_component
def: "The component of the Golgi membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:go_curators]
synonym: "Golgi integral membrane protein" RELATED []
synonym: "integral to Golgi membrane" NARROW []
is_a: GO:0031228 ! intrinsic component of Golgi membrane
is_a: GO:0031301 ! integral component of organelle membrane
intersection_of: GO:0016021 ! integral component of membrane
intersection_of: part_of GO:0000139 ! Golgi membrane
relationship: part_of GO:0000139 ! Golgi membrane

[Term]
id: GO:0030174
name: regulation of DNA-dependent DNA replication initiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of initiation of DNA-dependent DNA replication; the process in which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase." [GOC:mah]
subset: gosubset_prok
synonym: "DNA replication licencing" EXACT []
synonym: "DNA replication licensing" EXACT []
synonym: "regulation of DNA replication initiation" BROAD [GOC:vw]
is_a: GO:0090329 ! regulation of DNA-dependent DNA replication
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006270 ! DNA replication initiation
relationship: regulates GO:0006270 ! DNA replication initiation

[Term]
id: GO:0030175
name: filopodium
namespace: cellular_component
alt_id: GO:0030028
def: "Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft." [GOC:mah, GOC:pr, ISBN:0815316194]
comment: A filopodium may be approximately 0.1 um wide, 5-10 um long, and up to 50 um long in axon growth cones; contain a loose bundle of about 20 actin filaments oriented with their plus ends pointing outward. Note that filopodia on dendritic shafts are distinct from other types of filopodia (even those found in dendritic growth cones) and may react differently to stimuli, as shown in PMID:12904473.
subset: goslim_pir
xref: NIF_Subcellular:sao-1046371754
xref: Wikipedia:Filopodia
is_a: GO:0098858 ! actin-based cell projection

[Term]
id: GO:0030176
name: integral component of endoplasmic reticulum membrane
namespace: cellular_component
def: "The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]
synonym: "ER integral membrane protein" EXACT []
synonym: "integral to endoplasmic reticulum membrane" NARROW []
synonym: "integral to ER membrane" EXACT []
is_a: GO:0031227 ! intrinsic component of endoplasmic reticulum membrane
is_a: GO:0031301 ! integral component of organelle membrane
intersection_of: GO:0016021 ! integral component of membrane
intersection_of: part_of GO:0005789 ! endoplasmic reticulum membrane
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane

[Term]
id: GO:0030177
name: positive regulation of Wnt signaling pathway
namespace: biological_process
alt_id: GO:0045811
def: "Any process that activates or increases the frequency, rate or extent of Wnt signal transduction." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "activation of frizzled signaling pathway" NARROW []
synonym: "activation of Wnt receptor signaling pathway" NARROW []
synonym: "positive regulation of frizzled signaling pathway" EXACT []
synonym: "positive regulation of frizzled signalling pathway" EXACT []
synonym: "positive regulation of Wnt receptor signaling pathway" EXACT []
synonym: "positive regulation of Wnt receptor signalling pathway" EXACT []
synonym: "positive regulation of Wnt-activated signaling pathway" EXACT [GOC:signaling]
synonym: "stimulation of frizzled signaling pathway" NARROW []
synonym: "stimulation of Wnt receptor signaling pathway" NARROW []
synonym: "up regulation of frizzled signaling pathway" EXACT []
synonym: "up regulation of Wnt receptor signaling pathway" EXACT []
synonym: "up-regulation of frizzled signaling pathway" EXACT []
synonym: "up-regulation of Wnt receptor signaling pathway" EXACT []
synonym: "upregulation of frizzled signaling pathway" EXACT []
synonym: "upregulation of Wnt receptor signaling pathway" EXACT []
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0030111 ! regulation of Wnt signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016055 ! Wnt signaling pathway
relationship: positively_regulates GO:0016055 ! Wnt signaling pathway

[Term]
id: GO:0030178
name: negative regulation of Wnt signaling pathway
namespace: biological_process
alt_id: GO:0045810
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "down regulation of frizzled signaling pathway" EXACT []
synonym: "down regulation of Wnt receptor signaling pathway" EXACT []
synonym: "down-regulation of frizzled signaling pathway" EXACT []
synonym: "down-regulation of Wnt receptor signaling pathway" EXACT []
synonym: "downregulation of frizzled signaling pathway" EXACT []
synonym: "downregulation of Wnt receptor signaling pathway" EXACT []
synonym: "inhibition of frizzled signaling pathway" NARROW []
synonym: "inhibition of Wnt receptor signaling pathway" NARROW []
synonym: "negative regulation of frizzled signaling pathway" EXACT []
synonym: "negative regulation of frizzled signalling pathway" EXACT []
synonym: "negative regulation of Wnt receptor signaling pathway" EXACT []
synonym: "negative regulation of Wnt receptor signalling pathway" EXACT []
synonym: "negative regulation of Wnt-activated signaling pathway" EXACT [GOC:signaling]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0030111 ! regulation of Wnt signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016055 ! Wnt signaling pathway
relationship: negatively_regulates GO:0016055 ! Wnt signaling pathway

[Term]
id: GO:0030180
name: obsolete solute:solute exchange
namespace: biological_process
def: "OBSOLETE. Exchange diffusion of two solutes between the inside and outside of a cell or subcellular compartment, in which movement of one solute down a concentration gradient drives movement of the other solute in the opposite direction." [GOC:mah]
comment: This term was made obsolete because it represents a molecular function.
synonym: "solute:solute exchange" EXACT []
is_obsolete: true
consider: GO:0006810
consider: GO:0015297

[Term]
id: GO:0030181
name: obsolete sodium:calcium exchange
namespace: biological_process
def: "OBSOLETE. Exchange diffusion sodium and calcium ions in which influx of sodium ions to the cytosol drives the efflux of calcium ions from the cell." [GOC:mah, ISBN:0198506732]
comment: This term was made obsolete because it represents a function rather than a process.
synonym: "sodium:calcium exchange" EXACT []
is_obsolete: true
consider: GO:0005432
consider: GO:0006814
consider: GO:0006816

[Term]
id: GO:0030182
name: neuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0048699 ! generation of neurons

[Term]
id: GO:0030183
name: B cell differentiation
namespace: biological_process
alt_id: GO:0042115
def: "The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity." [GO_REF:0000022, GOC:mah, GOC:mtg_15nov05]
comment: This term was improved by GO_REF:0000022. It was moved. Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "B cell development" RELATED [GOC:add]
synonym: "B lymphocyte differentiation" EXACT []
synonym: "B-cell differentiation" EXACT []
synonym: "B-lymphocyte differentiation" EXACT []
is_a: GO:0030098 ! lymphocyte differentiation
is_a: GO:0042113 ! B cell activation

[Term]
id: GO:0030184
name: nitric oxide transmembrane transporter activity
namespace: molecular_function
def: "Enables the directed movement of nitric oxide, nitrogen monoxide, from one side of a membrane to the other." [GOC:mah]
subset: gosubset_prok
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity
relationship: part_of GO:0030185 ! nitric oxide transport

[Term]
id: GO:0030185
name: nitric oxide transport
namespace: biological_process
def: "The directed movement of nitric oxide, nitrogen monoxide, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
is_a: GO:0044765 ! single-organism transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0030186
name: melatonin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving melatonin (N-acetyl-5-methoxytryptamine)." [GOC:mah, ISBN:0198506732]
subset: gosubset_prok
synonym: "melatonin metabolism" EXACT []
is_a: GO:0034754 ! cellular hormone metabolic process
is_a: GO:0042430 ! indole-containing compound metabolic process
is_a: GO:0043603 ! cellular amide metabolic process

[Term]
id: GO:0030187
name: melatonin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of melatonin (N-acetyl-5-methoxytryptamine)." [GOC:mah, ISBN:0198506732]
subset: gosubset_prok
synonym: "melatonin anabolism" EXACT []
synonym: "melatonin biosynthesis" EXACT []
synonym: "melatonin formation" EXACT []
synonym: "melatonin synthesis" EXACT []
is_a: GO:0030186 ! melatonin metabolic process
is_a: GO:0042435 ! indole-containing compound biosynthetic process
is_a: GO:0042446 ! hormone biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process

[Term]
id: GO:0030188
name: obsolete chaperone regulator activity
namespace: molecular_function
def: "OBSOLETE. Modulates the activity of a molecular chaperone." [GOC:mah]
comment: This term was made obsolete because it refers to a obsolete molecular function term, 'chaperone activity'.
synonym: "chaperone regulator activity" EXACT []
is_obsolete: true
consider: GO:0006457
consider: GO:0051082
consider: GO:0051787

[Term]
id: GO:0030189
name: obsolete chaperone activator activity
namespace: molecular_function
def: "OBSOLETE. Increases the activity of a molecular chaperone." [GOC:mah]
comment: This term was made obsolete because it refers to a obsolete molecular function term, 'chaperone activity'.
subset: gosubset_prok
synonym: "chaperone activator activity" EXACT []
is_obsolete: true
consider: GO:0006457
consider: GO:0051082
consider: GO:0051787

[Term]
id: GO:0030190
name: obsolete chaperone inhibitor activity
namespace: molecular_function
def: "OBSOLETE. Stops, prevents or reduces the activity of a molecular chaperone." [GOC:mah]
comment: This term was made obsolete because it refers to a obsolete molecular function term, 'chaperone activity'.
synonym: "chaperone inhibitor activity" EXACT []
is_obsolete: true
consider: GO:0006457
consider: GO:0051082
consider: GO:0051787

[Term]
id: GO:0030191
name: obsolete Hsp70/Hsc70 protein inhibitor activity
namespace: molecular_function
def: "OBSOLETE. Stops, prevents or reduces the activity of chaperones of the Hsp70/Hsc70 class." [GOC:mah]
comment: This term was made obsolete because it refers to a non-existent molecular function term, 'Hsp70/Hsc70 protein activity'.
synonym: "Hsp70/Hsc70 protein inhibitor activity" EXACT []
is_obsolete: true
consider: GO:0006457
consider: GO:0051082
consider: GO:0051787

[Term]
id: GO:0030192
name: obsolete Hsp70/Hsc70 protein regulator activity
namespace: molecular_function
def: "OBSOLETE. Modulates the activity of chaperones of the Hsp70/Hsc70 class." [GOC:mah]
comment: This term was made obsolete because it refers to a non-existent molecular function term, 'Hsp70/Hsc70 protein activity'.
subset: gosubset_prok
synonym: "Hsp70/Hsc70 protein regulator activity" EXACT []
is_obsolete: true
consider: GO:0006457
consider: GO:0051082
consider: GO:0051787

[Term]
id: GO:0030193
name: regulation of blood coagulation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of blood coagulation." [GOC:mah]
is_a: GO:0032101 ! regulation of response to external stimulus
is_a: GO:0050818 ! regulation of coagulation
is_a: GO:0061041 ! regulation of wound healing
is_a: GO:1900046 ! regulation of hemostasis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007596 ! blood coagulation
relationship: regulates GO:0007596 ! blood coagulation

[Term]
id: GO:0030194
name: positive regulation of blood coagulation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of blood coagulation." [GOC:mah]
synonym: "activation of blood coagulation" NARROW []
synonym: "stimulation of blood coagulation" NARROW []
synonym: "up regulation of blood coagulation" EXACT []
synonym: "up-regulation of blood coagulation" EXACT []
synonym: "upregulation of blood coagulation" EXACT []
is_a: GO:0030193 ! regulation of blood coagulation
is_a: GO:0050820 ! positive regulation of coagulation
is_a: GO:0090303 ! positive regulation of wound healing
is_a: GO:1900048 ! positive regulation of hemostasis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007596 ! blood coagulation
relationship: positively_regulates GO:0007596 ! blood coagulation

[Term]
id: GO:0030195
name: negative regulation of blood coagulation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of blood coagulation." [GOC:mah]
synonym: "down regulation of blood coagulation" EXACT []
synonym: "down-regulation of blood coagulation" EXACT []
synonym: "downregulation of blood coagulation" EXACT []
synonym: "inhibition of blood coagulation" NARROW []
is_a: GO:0030193 ! regulation of blood coagulation
is_a: GO:0050819 ! negative regulation of coagulation
is_a: GO:0061045 ! negative regulation of wound healing
is_a: GO:1900047 ! negative regulation of hemostasis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007596 ! blood coagulation
relationship: negatively_regulates GO:0007596 ! blood coagulation

[Term]
id: GO:0030196
name: cyanide hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: formamide = H(2)O + hydrogen cyanide." [EC:4.2.1.66, RHEA:21723]
synonym: "formamide dehydratase activity" EXACT [EC:4.2.1.66]
synonym: "formamide hydro-lyase (cyanide-forming)" EXACT [EC:4.2.1.66]
synonym: "formamide hydro-lyase activity" EXACT [EC:4.2.1.66]
xref: EC:4.2.1.66
xref: KEGG:R01408
xref: MetaCyc:CYANIDE-HYDRATASE-RXN
xref: RHEA:21723
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0030197
name: extracellular matrix constituent, lubricant activity
namespace: molecular_function
def: "Functions as a lubricant for an extracellular matrix, such as a mucous membrane." [GOC:mah]
is_a: GO:0005201 ! extracellular matrix structural constituent

[Term]
id: GO:0030198
name: extracellular matrix organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]
subset: goslim_chembl
subset: goslim_generic
subset: gosubset_prok
synonym: "extracellular matrix organisation" EXACT [GOC:curators]
synonym: "extracellular matrix organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0043062 ! extracellular structure organization

[Term]
id: GO:0030199
name: collagen fibril organization
namespace: biological_process
def: "Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix." [GOC:mah, ISBN:0815316194]
synonym: "collagen fibril organisation" EXACT [GOC:curators]
synonym: "fibrillar collagen organization" EXACT [GOC:mah]
is_a: GO:0030198 ! extracellular matrix organization
is_a: GO:0071822 ! protein complex subunit organization

[Term]
id: GO:0030200
name: heparan sulfate proteoglycan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of proteoglycan containing heparan sulfate, any member of a group of glycosaminoglycans that have repeat units consisting of alternating alpha-(1->4) linked hexuronic acid and glucosamine residues, the former being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter being either sulfated or acetylated on its amino group as well as sulfated on one of its hydroxyl groups." [GOC:mah, ISBN:0198506732]
subset: gosubset_prok
synonym: "heparan sulfate proteoglycan breakdown" EXACT []
synonym: "heparan sulfate proteoglycan catabolism" EXACT []
synonym: "heparan sulfate proteoglycan degradation" EXACT []
synonym: "heparan sulphate proteoglycan catabolic process" EXACT []
synonym: "heparan sulphate proteoglycan catabolism" EXACT []
synonym: "heparin proteoglycan catabolic process" RELATED []
is_a: GO:0030167 ! proteoglycan catabolic process
is_a: GO:0030201 ! heparan sulfate proteoglycan metabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0044712 ! single-organism catabolic process

[Term]
id: GO:0030201
name: heparan sulfate proteoglycan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any proteoglycan containing heparan sulfate, any member of a group of glycosaminoglycans that have repeat units consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues, the former being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter being either sulfated or acetylated on its amino group as well as sulfated on one of its hydroxyl groups." [GOC:mah, ISBN:0198506732]
subset: gosubset_prok
synonym: "heparan sulfate proteoglycan metabolism" EXACT []
synonym: "heparan sulphate proteoglycan metabolic process" EXACT []
synonym: "heparan sulphate proteoglycan metabolism" EXACT []
synonym: "heparin proteoglycan metabolic process" RELATED []
is_a: GO:0006029 ! proteoglycan metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0043436 ! oxoacid metabolic process

[Term]
id: GO:0030202
name: heparin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells. They are similar to heparan sulfates but are of somewhat higher average Mr (6000-20000) and contain fewer N-acetyl groups and more N-sulfate and O-sulfate groups; they may be attached in the same manner to protein, forming proteoglycans. They consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:mah, ISBN:0198506732]
subset: gosubset_prok
synonym: "heparan sulfate metabolic process" RELATED []
synonym: "heparin metabolism" EXACT []
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0043436 ! oxoacid metabolic process
is_a: GO:1903510 ! mucopolysaccharide metabolic process

[Term]
id: GO:0030203
name: glycosaminoglycan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars. Formerly known as mucopolysaccharides, they include hyaluronic acid and chondroitin, which provide lubrication in joints and form part of the matrix of cartilage. The three-dimensional structure of these molecules enables them to trap water, which forms a gel and gives glycosaminoglycans their elastic properties." [ISBN:0192800981]
subset: gosubset_prok
synonym: "glycosaminoglycan metabolism" EXACT []
is_a: GO:0006022 ! aminoglycan metabolic process

[Term]
id: GO:0030204
name: chondroitin sulfate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. They usually occur linked to a protein to form proteoglycans. Two subgroups exist, one in which the sulfate is on the 4-position (chondroitin sulfate A) and the second in which it is in the 6-position (chondroitin sulfate C). They often are polydisperse and often differ in the degree of sulfation from tissue to tissue. The chains of repeating disaccharide are covalently linked to the side chains of serine residues in the polypeptide backbone of a protein by a glycosidic attachment through the trisaccharide unit galactosyl-galactosyl-xylosyl. Chondroitin sulfate B is more usually known as dermatan sulfate." [GOC:mah, ISBN:0198506732]
subset: gosubset_prok
synonym: "chondroitin sulfate metabolism" EXACT []
synonym: "chondroitin sulphate metabolic process" EXACT []
synonym: "chondroitin sulphate metabolism" EXACT []
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0043436 ! oxoacid metabolic process
is_a: GO:1903510 ! mucopolysaccharide metabolic process
relationship: part_of GO:0050654 ! chondroitin sulfate proteoglycan metabolic process

[Term]
id: GO:0030205
name: dermatan sulfate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dermatan sulfate, any of a group of glycosaminoglycans with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units. They are important components of ground substance or intercellular cement of skin and some connective tissues." [GOC:mah, ISBN:0198506732]
subset: gosubset_prok
synonym: "chondroitin sulfate B metabolic process" EXACT []
synonym: "chondroitin sulfate B metabolism" EXACT []
synonym: "dermatan sulfate metabolism" EXACT []
synonym: "dermatan sulphate metabolic process" EXACT []
synonym: "dermatan sulphate metabolism" EXACT []
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:1903510 ! mucopolysaccharide metabolic process
relationship: part_of GO:0050655 ! dermatan sulfate proteoglycan metabolic process

[Term]
id: GO:0030206
name: chondroitin sulfate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:mah, ISBN:0198506732]
subset: gosubset_prok
synonym: "chondroitin sulfate anabolism" EXACT []
synonym: "chondroitin sulfate biosynthesis" EXACT []
synonym: "chondroitin sulfate formation" EXACT []
synonym: "chondroitin sulfate synthesis" EXACT []
synonym: "chondroitin sulphate biosynthesis" EXACT []
synonym: "chondroitin sulphate biosynthetic process" EXACT []
is_a: GO:0006024 ! glycosaminoglycan biosynthetic process
is_a: GO:0030204 ! chondroitin sulfate metabolic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
relationship: part_of GO:0050650 ! chondroitin sulfate proteoglycan biosynthetic process

[Term]
id: GO:0030207
name: chondroitin sulfate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:mah, ISBN:0198506732]
subset: gosubset_prok
synonym: "chondroitin sulfate breakdown" EXACT []
synonym: "chondroitin sulfate catabolism" EXACT []
synonym: "chondroitin sulfate degradation" EXACT []
synonym: "chondroitin sulphate catabolic process" EXACT []
synonym: "chondroitin sulphate catabolism" EXACT []
is_a: GO:0006027 ! glycosaminoglycan catabolic process
is_a: GO:0030204 ! chondroitin sulfate metabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0044712 ! single-organism catabolic process

[Term]
id: GO:0030208
name: dermatan sulfate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dermatan sulfate, any glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units." [GOC:mah, ISBN:0198506732]
subset: gosubset_prok
synonym: "chondroitin sulfate B biosynthesis" EXACT []
synonym: "chondroitin sulfate B biosynthetic process" EXACT []
synonym: "dermatan sulfate anabolism" EXACT []
synonym: "dermatan sulfate biosynthesis" EXACT []
synonym: "dermatan sulfate formation" EXACT []
synonym: "dermatan sulfate synthesis" EXACT []
synonym: "dermatan sulphate biosynthesis" EXACT []
synonym: "dermatan sulphate biosynthetic process" EXACT []
is_a: GO:0006024 ! glycosaminoglycan biosynthetic process
is_a: GO:0030205 ! dermatan sulfate metabolic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
relationship: part_of GO:0050651 ! dermatan sulfate proteoglycan biosynthetic process

[Term]
id: GO:0030209
name: dermatan sulfate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dermatan sulfate, any of a group of glycosaminoglycans with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units." [GOC:mah, ISBN:0198506732]
subset: gosubset_prok
synonym: "chondroitin sulfate B catabolic process" EXACT []
synonym: "chondroitin sulfate B catabolism" EXACT []
synonym: "dermatan sulfate breakdown" EXACT []
synonym: "dermatan sulfate catabolism" EXACT []
synonym: "dermatan sulfate degradation" EXACT []
synonym: "dermatan sulphate catabolic process" EXACT []
synonym: "dermatan sulphate catabolism" EXACT []
is_a: GO:0006027 ! glycosaminoglycan catabolic process
is_a: GO:0030205 ! dermatan sulfate metabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0030210
name: heparin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:mah, ISBN:0198506732]
subset: gosubset_prok
synonym: "heparan sulfate biosynthetic process" RELATED []
synonym: "heparin anabolism" EXACT []
synonym: "heparin biosynthesis" EXACT []
synonym: "heparin formation" EXACT []
synonym: "heparin synthesis" EXACT []
is_a: GO:0006024 ! glycosaminoglycan biosynthetic process
is_a: GO:0030202 ! heparin metabolic process
is_a: GO:0044272 ! sulfur compound biosynthetic process

[Term]
id: GO:0030211
name: heparin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:mah, ISBN:0198506732]
subset: gosubset_prok
synonym: "heparan sulfate catabolic process" RELATED []
synonym: "heparin breakdown" EXACT []
synonym: "heparin catabolism" EXACT []
synonym: "heparin degradation" EXACT []
is_a: GO:0006027 ! glycosaminoglycan catabolic process
is_a: GO:0030202 ! heparin metabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0044712 ! single-organism catabolic process

[Term]
id: GO:0030212
name: hyaluronan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine." [GOC:mah, ISBN:0198506732]
subset: gosubset_prok
synonym: "hyaluronan metabolism" EXACT []
is_a: GO:1903510 ! mucopolysaccharide metabolic process

[Term]
id: GO:0030213
name: hyaluronan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine." [GOC:mah, ISBN:0198506732]
subset: gosubset_prok
synonym: "hyaluronan anabolism" EXACT []
synonym: "hyaluronan biosynthesis" EXACT []
synonym: "hyaluronan formation" EXACT []
synonym: "hyaluronan synthesis" EXACT []
is_a: GO:0006024 ! glycosaminoglycan biosynthetic process
is_a: GO:0030212 ! hyaluronan metabolic process

[Term]
id: GO:0030214
name: hyaluronan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine." [GOC:mah, ISBN:0198506732]
subset: gosubset_prok
synonym: "hyaluronan breakdown" EXACT []
synonym: "hyaluronan catabolism" EXACT []
synonym: "hyaluronan degradation" EXACT []
is_a: GO:0006027 ! glycosaminoglycan catabolic process
is_a: GO:0030212 ! hyaluronan metabolic process
is_a: GO:0044712 ! single-organism catabolic process

[Term]
id: GO:0030215
name: semaphorin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with semaphorin receptors." [GOC:ceb, PMID:12001990]
synonym: "plexin binding" NARROW []
synonym: "plexin ligand" NARROW []
synonym: "semaphorin receptor ligand" NARROW []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0030216
name: keratinocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte." [GOC:dph, GOC:mah, GOC:sdb_2009, GOC:tb]
synonym: "keratinocyte cell differentiation" EXACT []
is_a: GO:0009913 ! epidermal cell differentiation
relationship: part_of GO:0043588 ! skin development

[Term]
id: GO:0030217
name: T cell differentiation
namespace: biological_process
alt_id: GO:0042112
alt_id: GO:0046652
def: "The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex." [GO_REF:0000022, GOC:jid, GOC:mah, GOC:mtg_15nov05]
comment: This term was improved by GO_REF:0000022. It was moved. Note that the term 'thymocyte differentiation' was merged into this term because thymocytes are T cells, and thus the term was essentially redundant. Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "T cell development" RELATED [GOC:add]
synonym: "T lymphocyte differentiation" EXACT []
synonym: "T-cell differentiation" EXACT []
synonym: "T-lymphocyte differentiation" EXACT []
is_a: GO:0030098 ! lymphocyte differentiation
is_a: GO:0042110 ! T cell activation

[Term]
id: GO:0030218
name: erythrocyte differentiation
namespace: biological_process
def: "The process in which a myeloid precursor cell acquires specializes features of an erythrocyte." [GOC:mah]
synonym: "erythrocyte cell differentiation" EXACT []
synonym: "erythropoiesis" EXACT [GOC:add, GOC:dph]
synonym: "RBC differentiation" EXACT [CL:0000232]
synonym: "red blood cell differentiation" EXACT [CL:0000232]
xref: Wikipedia:Erythropoiesis
is_a: GO:0030099 ! myeloid cell differentiation
relationship: part_of GO:0034101 ! erythrocyte homeostasis

[Term]
id: GO:0030219
name: megakaryocyte differentiation
namespace: biological_process
def: "The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte." [GOC:mah]
synonym: "megakaryocyte cell differentiation" EXACT []
is_a: GO:0002244 ! hematopoietic progenitor cell differentiation
is_a: GO:0030099 ! myeloid cell differentiation

[Term]
id: GO:0030220
name: platelet formation
namespace: biological_process
def: "The process in which platelets bud from long processes extended by megakaryocytes." [GOC:mah, ISBN:0815316194]
synonym: "platelet extrusion" EXACT systematic_synonym [GOC:curators]
is_a: GO:0030099 ! myeloid cell differentiation
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0036344 ! platelet morphogenesis

[Term]
id: GO:0030221
name: basophil differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized myeloid precursor cell acquires specialized features of a basophil cell." [GOC:jid, GOC:mah]
synonym: "basophil cell differentiation" EXACT []
is_a: GO:0030851 ! granulocyte differentiation

[Term]
id: GO:0030222
name: eosinophil differentiation
namespace: biological_process
alt_id: GO:0035856
def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specializes features of an eosinophil." [GOC:add, GOC:mah]
synonym: "eosinophil cell development" RELATED [GOC:bf]
synonym: "eosinophil cell differentiation" EXACT []
synonym: "eosinophil development" RELATED []
is_a: GO:0030851 ! granulocyte differentiation
is_a: GO:0048468 ! cell development

[Term]
id: GO:0030223
name: neutrophil differentiation
namespace: biological_process
def: "The process in which a myeloid precursor cell acquires the specialized features of a neutrophil." [GOC:mah]
synonym: "neutrophil cell differentiation" EXACT []
synonym: "neutrophil granulocyte differentiation" EXACT [GOC:yaf]
synonym: "neutrophil granulocytopoiesis" EXACT [GOC:yaf]
is_a: GO:0030851 ! granulocyte differentiation

[Term]
id: GO:0030224
name: monocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte." [GOC:mah]
synonym: "monocyte cell differentiation" EXACT []
is_a: GO:0002573 ! myeloid leukocyte differentiation

[Term]
id: GO:0030225
name: macrophage differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage." [GOC:add, ISBN:0781735149]
synonym: "macrophage cell differentiation" EXACT []
is_a: GO:0002573 ! myeloid leukocyte differentiation

[Term]
id: GO:0030226
name: apolipoprotein receptor activity
namespace: molecular_function
def: "Combining with an apolipoprotein to initiate a change in cell activity." [GOC:mah, ISBN:0198506732]
is_a: GO:0004872 ! receptor activity
relationship: has_part GO:0034185 ! apolipoprotein binding

[Term]
id: GO:0030227
name: obsolete apolipoprotein E receptor activity
namespace: molecular_function
def: "OBSOLETE. Combining with apolipoprotein E to initiate a change in cell activity." [GOC:mah]
comment: This term was made obsolete because no known receptor binds apolipoprotein E; instead, receptors bind holo-lipoprotein E (apolipoprotein E + bound lipid).
synonym: "ApoE receptor" EXACT []
synonym: "apolipoprotein E receptor activity" EXACT []
is_obsolete: true
replaced_by: GO:0030229

[Term]
id: GO:0030228
name: lipoprotein particle receptor activity
namespace: molecular_function
def: "Combining with a lipoprotein particle and delivering the lipoprotein particle into the cell via endocytosis. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids." [CHEBI:6495, GOC:bf, GOC:mah, PMID:12827279]
comment: This term is intended for cell surface receptors that bind and internalize a lipoprotein particle. For members of the lipoprotein receptor family that transduce a signal rather than endocytose their ligand, consider instead the terms 'signaling receptor activity ; GO:0038023' and its children, or 'reelin receptor activity ; GO:0038025'.
subset: gosubset_prok
synonym: "lipoprotein receptor activity" EXACT [GOC:dph]
synonym: "plasma lipoprotein particle receptor activity" EXACT [GOC:BHF]
is_a: GO:0038024 ! cargo receptor activity
relationship: has_part GO:0071813 ! lipoprotein particle binding

[Term]
id: GO:0030229
name: very-low-density lipoprotein particle receptor activity
namespace: molecular_function
def: "Combining with a very-low-density lipoprotein particle and delivering the very-low-density lipoprotein into the cell via endocytosis." [GOC:bf, ISBN:0198506732]
synonym: "apolipoprotein E receptor activity" RELATED [GOC:rl]
synonym: "very-low-density lipoprotein receptor activity" EXACT [GOC:dph]
synonym: "VLDL receptor" EXACT []
xref: Wikipedia:VLDL_receptor
is_a: GO:0030228 ! lipoprotein particle receptor activity
relationship: has_part GO:0034189 ! very-low-density lipoprotein particle binding

[Term]
id: GO:0030232
name: insulin control element activator complex
namespace: cellular_component
def: "Transcription factor complex that binds to the insulin control element (ICE), a DNA sequence element found within the 5'-flanking region of the insulin gene, and activates ICE-mediated transcription." [PMID:7935390]
synonym: "ICE activator complex" EXACT []
is_a: GO:0090575 ! RNA polymerase II transcription factor complex

[Term]
id: GO:0030233
name: deoxynucleotide transmembrane transporter activity
namespace: molecular_function
def: "Catalyzes transport of all four deoxy (d) NDPs, and, less efficiently, the corresponding dNTPs, in exchange for dNDPs, ADP, or ATP." [PMID:11226231]
is_a: GO:0015215 ! nucleotide transmembrane transporter activity
relationship: part_of GO:0030302 ! deoxynucleotide transport

[Term]
id: GO:0030234
name: enzyme regulator activity
namespace: molecular_function
alt_id: GO:0010576
def: "Binds to and modulates the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]
comment: GO:0030234 is reserved for cases when the regulator directly interacts with the enzyme. When regulation of enzyme activity is achieved without enzyme binding, or when the mechanism of regulation is unknown, instead annotate to 'regulation of catalytic activity ; GO:0050790'.
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "catalytic regulator activity" EXACT [GOC:dph]
synonym: "enzyme modulator" EXACT []
synonym: "metalloenzyme regulator activity" NARROW []
is_a: GO:0098772 ! molecular function regulator
relationship: has_part GO:0019899 ! enzyme binding
relationship: part_of GO:0050790 ! regulation of catalytic activity
relationship: regulates GO:0003824 ! catalytic activity

[Term]
id: GO:0030235
name: nitric-oxide synthase regulator activity
namespace: molecular_function
def: "Modulates the activity of nitric oxide synthase." [GOC:mah]
comment: See also 'regulation of nitric-oxide synthase activity ; GO:0050999'.
synonym: "nitric oxide synthase regulator activity" EXACT []
is_a: GO:0030234 ! enzyme regulator activity
relationship: has_part GO:0050998 ! nitric-oxide synthase binding
relationship: regulates GO:0004517 ! nitric-oxide synthase activity

[Term]
id: GO:0030237
name: female sex determination
namespace: biological_process
def: "The specification of female sex of an individual organism." [GOC:mah, ISBN:0198506732]
is_a: GO:0007530 ! sex determination
relationship: part_of GO:0007275 ! multicellular organism development

[Term]
id: GO:0030238
name: male sex determination
namespace: biological_process
def: "The specification of male sex of an individual organism." [GOC:mah]
is_a: GO:0007530 ! sex determination
relationship: part_of GO:0007275 ! multicellular organism development

[Term]
id: GO:0030239
name: myofibril assembly
namespace: biological_process
def: "Formation of myofibrils, the repeating units of striated muscle." [GOC:mah]
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
is_a: GO:0031032 ! actomyosin structure organization
is_a: GO:0070925 ! organelle assembly
relationship: part_of GO:0055002 ! striated muscle cell development

[Term]
id: GO:0030240
name: skeletal muscle thin filament assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins to form the actin-based thin filaments of myofibrils in skeletal muscle." [GOC:ef, GOC:mah, GOC:mtg_muscle]
is_a: GO:0007015 ! actin filament organization
relationship: part_of GO:0014866 ! skeletal myofibril assembly

[Term]
id: GO:0030241
name: skeletal muscle myosin thick filament assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins to form the myosin-based thick filaments of myofibrils in skeletal muscle." [GOC:ef, GOC:mah, GOC:mtg_muscle]
is_a: GO:0071688 ! striated muscle myosin thick filament assembly
relationship: part_of GO:0014866 ! skeletal myofibril assembly

[Term]
id: GO:0030242
name: pexophagy
namespace: biological_process
def: "The process in which peroxisomes are delivered to the vacuole and degraded in response to changing nutrient conditions." [GOC:autophagy, PMID:10547367, PMID:20083110]
synonym: "peroxisome degradation" BROAD []
is_a: GO:0006914 ! autophagy
is_a: GO:0007031 ! peroxisome organization
is_a: GO:0044712 ! single-organism catabolic process
is_a: GO:1902589 ! single-organism organelle organization

[Term]
id: GO:0030243
name: cellulose metabolic process
namespace: biological_process
alt_id: GO:0016177
def: "The chemical reactions and pathways involving cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation." [GOC:mah, ISBN:0198506732]
subset: gosubset_prok
synonym: "cellulose metabolism" EXACT []
is_a: GO:0051273 ! beta-glucan metabolic process

[Term]
id: GO:0030244
name: cellulose biosynthetic process
namespace: biological_process
alt_id: GO:0016178
def: "The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation." [GOC:mah, ISBN:0198506732]
subset: gosubset_prok
synonym: "cellulose anabolism" EXACT []
synonym: "cellulose biosynthesis" EXACT []
synonym: "cellulose formation" EXACT []
synonym: "cellulose synthesis" EXACT []
xref: MetaCyc:PWY-1001
is_a: GO:0030243 ! cellulose metabolic process
is_a: GO:0051274 ! beta-glucan biosynthetic process

[Term]
id: GO:0030245
name: cellulose catabolic process
namespace: biological_process
alt_id: GO:0016179
def: "The chemical reactions and pathways resulting in the breakdown of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation." [GOC:mah, ISBN:0198506732]
subset: gosubset_prok
synonym: "cellulose breakdown" EXACT []
synonym: "cellulose catabolism" EXACT []
synonym: "cellulose degradation" EXACT []
is_a: GO:0030243 ! cellulose metabolic process
is_a: GO:0051275 ! beta-glucan catabolic process

[Term]
id: GO:0030246
name: carbohydrate binding
namespace: molecular_function
alt_id: GO:0005529
def: "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
subset: goslim_chembl
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "selectin" RELATED []
synonym: "sugar binding" EXACT []
is_a: GO:0005488 ! binding

[Term]
id: GO:0030247
name: polysaccharide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [CHEBI:18154, GOC:mah]
subset: gosubset_prok
is_a: GO:0001871 ! pattern binding
is_a: GO:0030246 ! carbohydrate binding

[Term]
id: GO:0030248
name: cellulose binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with cellulose." [GOC:mah]
subset: gosubset_prok
is_a: GO:0030247 ! polysaccharide binding

[Term]
id: GO:0030249
name: guanylate cyclase regulator activity
namespace: molecular_function
def: "Modulates the activity of guanylate cyclase." [GOC:mah]
is_a: GO:0010851 ! cyclase regulator activity
relationship: part_of GO:0031282 ! regulation of guanylate cyclase activity
relationship: regulates GO:0004383 ! guanylate cyclase activity

[Term]
id: GO:0030250
name: guanylate cyclase activator activity
namespace: molecular_function
def: "Binds to and increases the activity of guanylate cyclase." [GOC:mah]
synonym: "guanylin" NARROW []
is_a: GO:0008047 ! enzyme activator activity
is_a: GO:0010853 ! cyclase activator activity
is_a: GO:0030249 ! guanylate cyclase regulator activity
relationship: part_of GO:0031284 ! positive regulation of guanylate cyclase activity
relationship: positively_regulates GO:0004383 ! guanylate cyclase activity

[Term]
id: GO:0030251
name: guanylate cyclase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of guanylate cyclase." [GOC:mah]
is_a: GO:0004857 ! enzyme inhibitor activity
is_a: GO:0010852 ! cyclase inhibitor activity
is_a: GO:0030249 ! guanylate cyclase regulator activity
relationship: negatively_regulates GO:0004383 ! guanylate cyclase activity
relationship: part_of GO:0031283 ! negative regulation of guanylate cyclase activity

[Term]
id: GO:0030252
name: growth hormone secretion
namespace: biological_process
def: "The regulated release of growth hormone from secretory granules into the blood." [GOC:mah]
synonym: "somatotropin secretion" EXACT [GOC:mah]
is_a: GO:0030072 ! peptide hormone secretion

[Term]
id: GO:0030253
name: protein secretion by the type I secretion system
namespace: biological_process
def: "The process in which proteins are secreted into the extracellular milieu via the type I secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins." [GOC:pamgo_curators]
comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular component term 'type I protein secretion system complex ; GO:0030256'.
synonym: "protein secretion by the TOSS" EXACT []
synonym: "protein secretion by the type I protein secretion system" EXACT []
synonym: "type I protein secretion system" EXACT []
is_a: GO:0009306 ! protein secretion
is_a: GO:0071806 ! protein transmembrane transport

[Term]
id: GO:0030254
name: protein secretion by the type III secretion system
namespace: biological_process
def: "The process in which proteins are transferred into the extracellular milieu or directly into host cells by the bacterial type III secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins." [GOC:pamgo_curators]
comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular component term 'type III protein secretion system complex ; GO:0030257'. Note that this term is used for annotation of proteins that compose the secretion complex but not the proteins being secreted.
subset: gosubset_prok
synonym: "protein secretion by the T3S" EXACT []
synonym: "protein secretion by the T3SS" EXACT []
synonym: "protein secretion by the TTSS" EXACT []
synonym: "protein secretion by the type III protein secretion system" EXACT []
synonym: "type III protein secretion system" EXACT []
is_a: GO:0009306 ! protein secretion
is_a: GO:0071806 ! protein transmembrane transport

[Term]
id: GO:0030255
name: protein secretion by the type IV secretion system
namespace: biological_process
def: "The process in which proteins are transferred into the extracellular milieu or directly into host cells, via the type IV protein secretion system." [GOC:pamgo_curators]
comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular component term 'type IV protein secretion system complex ; GO:0043684'.
subset: gosubset_prok
synonym: "protein secretion by the T4SS" EXACT []
synonym: "protein secretion by the type IV protein secretion system" EXACT []
synonym: "type IV protein secretion system" NARROW []
is_a: GO:0009306 ! protein secretion
is_a: GO:0044097 ! secretion by the type IV secretion system
is_a: GO:0071806 ! protein transmembrane transport

[Term]
id: GO:0030256
name: type I protein secretion system complex
namespace: cellular_component
def: "A complex of three secretory proteins that carry out secretion in the type I secretion system: an inner membrane transport ATPase (termed ABC protein for ATP-binding cassette), which provides the energy for protein secretion; an outer membrane protein, which is exported via the sec pathway; and a membrane fusion protein, which is anchored in the inner membrane and spans the periplasmic space." [PMID:9618447]
subset: gosubset_prok
synonym: "ABC translocator complex" BROAD []
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0030257
name: type III protein secretion system complex
namespace: cellular_component
def: "A complex of approximately 20 proteins, most of which are located in the cytoplasmic membrane that carries out protein secretion in the bacterial type III secretion system; type III secretion also requires a cytoplasmic, probably membrane-associated ATPase." [PMID:9618447]
subset: gosubset_prok
synonym: "T3SS complex" EXACT []
synonym: "TTSS complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0030258
name: lipid modification
namespace: biological_process
def: "The covalent alteration of one or more fatty acids in a lipid, resulting in a change in the properties of the lipid." [GOC:mah]
subset: gosubset_prok
is_a: GO:0044255 ! cellular lipid metabolic process

[Term]
id: GO:0030259
name: lipid glycosylation
namespace: biological_process
def: "Covalent attachment of a glycosyl residue to a lipid molecule." [GOC:mah]
subset: gosubset_prok
is_a: GO:0030258 ! lipid modification
is_a: GO:0070085 ! glycosylation

[Term]
id: GO:0030260
name: entry into host cell
namespace: biological_process
def: "The invasion by an organism of a cell of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:njm]
subset: gosubset_prok
synonym: "host cell invasion" EXACT []
xref: Reactome:REACT_6903 "Binding and entry of HIV virion, Homo sapiens"
is_a: GO:0044409 ! entry into host
is_a: GO:0051806 ! entry into cell of other organism involved in symbiotic interaction

[Term]
id: GO:0030261
name: chromosome condensation
namespace: biological_process
alt_id: GO:0000068
def: "The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." [GOC:mah, ISBN:0815316194]
synonym: "DNA condensation" BROAD [Wikipedia:DNA_condensation]
synonym: "eukaryotic chromosome condensation" EXACT [GOC:bf]
synonym: "nuclear chromosome condensation" EXACT [GOC:bf]
is_a: GO:0006323 ! DNA packaging
is_a: GO:1902589 ! single-organism organelle organization

[Term]
id: GO:0030262
name: apoptotic nuclear changes
namespace: biological_process
def: "Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis." [GOC:mah, GOC:mtg_apoptosis]
synonym: "apoptotic nuclear change" NARROW []
is_a: GO:0006921 ! cellular component disassembly involved in execution phase of apoptosis

[Term]
id: GO:0030263
name: apoptotic chromosome condensation
namespace: biological_process
def: "The compaction of chromatin during apoptosis." [GOC:mah]
synonym: "pyknosis" EXACT []
xref: Wikipedia:Pyknosis
is_a: GO:0030261 ! chromosome condensation
relationship: part_of GO:0030262 ! apoptotic nuclear changes

[Term]
id: GO:0030264
name: nuclear fragmentation involved in apoptotic nuclear change
namespace: biological_process
def: "The breakdown of the nucleus into small membrane-bounded compartments, or blebs, each of which contain compacted DNA." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, ISBN:0721639976]
synonym: "apoptotic nuclear fragmentation" EXACT []
synonym: "nuclear fragmentation during apoptosis" RELATED [GOC:dph, GOC:tb]
synonym: "nucleus fragmentation" EXACT []
is_a: GO:0071763 ! nuclear membrane organization
intersection_of: GO:0071763 ! nuclear membrane organization
intersection_of: part_of GO:0030262 ! apoptotic nuclear changes
relationship: part_of GO:0030262 ! apoptotic nuclear changes

[Term]
id: GO:0030265
name: phospholipase C-activating rhodopsin mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a rhodopsin molecule being activated by a photon, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:mah, GOC:signaling, PMID:22498302, PMID:8823931]
synonym: "phospholipase C-activating rhodopsin mediated G-protein coupled receptor signaling pathway" EXACT [GOC:bf]
synonym: "PLC-activating rhodopsin mediated signaling pathway" EXACT [GOC:bf]
synonym: "rhodopsin mediated G protein signaling, coupled to IP3 second messenger" EXACT []
synonym: "rhodopsin mediated G protein signalling, coupled to IP3 second messenger" EXACT []
synonym: "rhodopsin mediated G-protein signaling, coupled to IP3 second messenger" EXACT [GOC:signaling]
synonym: "rhodopsin mediated G-protein signalling, coupled to IP3 second messenger" EXACT []
is_a: GO:0007200 ! phospholipase C-activating G-protein coupled receptor signaling pathway
is_a: GO:0016056 ! rhodopsin mediated signaling pathway

[Term]
id: GO:0030266
name: quinate 3-dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: (-)-quinate + NAD+ = (-)-3-dehydroquinate + NADH + H+." [EC:1.1.1.24]
synonym: "quinate:NAD 3-oxidoreductase activity" EXACT []
synonym: "quinate:NAD 5-oxidoreductase activity" EXACT [EC:1.1.1.24]
synonym: "quinate:NAD(+) 3-oxidoreductase activity" EXACT []
synonym: "quinate:NAD(+) 5-oxidoreductase activity" EXACT [EC:1.1.1.24]
synonym: "quinic dehydrogenase activity" BROAD [EC:1.1.1.24]
xref: EC:1.1.1.24
xref: EC:1.1.1.282
xref: KEGG:R01872
xref: MetaCyc:QUINATE-5-DEHYDROGENASE-RXN
xref: RHEA:22367
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0030267
name: glyoxylate reductase (NADP) activity
namespace: molecular_function
def: "Catalysis of the reaction: glycolate + NADP+ = glyoxylate + NADPH + H+." [EC:1.1.1.79]
subset: gosubset_prok
synonym: "glycolate:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.79]
synonym: "glyoxylate reductase (NADP+)" EXACT [EC:1.1.1.79]
synonym: "NADPH-glyoxylate reductase activity" EXACT [EC:1.1.1.79]
xref: EC:1.1.1.79
xref: MetaCyc:GLYOXYLATE-REDUCTASE-NADP+-RXN
xref: Reactome:REACT_101458 "glyoxylate + NADPH + H+ => glycolate + NADP+, Gallus gallus"
xref: Reactome:REACT_104969 "glyoxylate + NADPH + H+ => glycolate + NADP+, Escherichia coli"
xref: Reactome:REACT_105527 "glyoxylate + NADPH + H+ => glycolate + NADP+, Dictyostelium discoideum"
xref: Reactome:REACT_16910 "glyoxylate + NADPH + H+ => glycolate + NADP+, Homo sapiens"
xref: Reactome:REACT_29565 "glyoxylate + NADPH + H+ => glycolate + NADP+, Sus scrofa"
xref: Reactome:REACT_78509 "glyoxylate + NADPH + H+ => glycolate + NADP+, Mus musculus"
xref: Reactome:REACT_79757 "glyoxylate + NADPH + H+ => glycolate + NADP+, Danio rerio"
xref: Reactome:REACT_87538 "glyoxylate + NADPH + H+ => glycolate + NADP+, Bos taurus"
xref: Reactome:REACT_89652 "glyoxylate + NADPH + H+ => glycolate + NADP+, Drosophila melanogaster"
xref: Reactome:REACT_91319 "glyoxylate + NADPH + H+ => glycolate + NADP+, Canis familiaris"
xref: Reactome:REACT_93956 "glyoxylate + NADPH + H+ => glycolate + NADP+, Staphylococcus aureus N315"
xref: Reactome:REACT_95180 "glyoxylate + NADPH + H+ => glycolate + NADP+, Taeniopygia guttata"
xref: Reactome:REACT_97039 "glyoxylate + NADPH + H+ => glycolate + NADP+, Xenopus tropicalis"
xref: Reactome:REACT_99709 "glyoxylate + NADPH + H+ => glycolate + NADP+, Rattus norvegicus"
xref: RHEA:10995
xref: Wikipedia:Glyoxylate_reductase_(NADP+)
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0030268
name: methylenetetrahydromethanopterin dehydrogenase activity
namespace: molecular_function
alt_id: GO:0018536
def: "Catalysis of the reaction: 5,10-methylenetetrahydromethanopterin + coenzyme F420 + 2 H(+) = 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + reduced coenzyme F420." [EC:1.5.99.9, RHEA:16724]
subset: gosubset_prok
synonym: "5,10-methylenetetrahydromethanopterin dehydrogenase activity" EXACT [EC:1.5.99.9]
synonym: "5,10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase activity" EXACT [EC:1.5.99.9]
synonym: "N(5),N(10)-methylenetetrahydromethanopterin dehydrogenase activity" EXACT [EC:1.5.99.9]
xref: EC:1.5.99.9
xref: KEGG:R04456
xref: MetaCyc:1.5.99.9-RXN
xref: RHEA:16724
xref: UM-BBD_reactionID:r0348
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0030269
name: tetrahydromethanopterin S-methyltransferase activity
namespace: molecular_function
alt_id: GO:0018709
def: "Catalysis of the reaction: 5-methyltetrahydromethanopterin + coenzyme M = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M. 2-(methylthio)ethanesulfonate is also known as methyl-CoM." [EC:2.1.1.86, RHEA:17588]
subset: gosubset_prok
synonym: "5-methyl-5,6,7,8-tetrahydromethanopterin:2-mercaptoethanesulfonate 2-methyltransferase activity" EXACT [EC:2.1.1.86]
synonym: "N(5)-methyltetrahydromethanopterin--coenzyme M methyltransferase activity" EXACT [EC:2.1.1.86]
synonym: "N5-methyltetrahydromethanopterin--coenzyme M methyltransferase activity" EXACT [EC:2.1.1.86]
synonym: "tetrahydromethanopterin methyltransferase activity" EXACT [EC:2.1.1.86]
xref: EC:2.1.1.86
xref: KEGG:R04347
xref: MetaCyc:2.1.1.86-RXN
xref: RHEA:17588
xref: UM-BBD_reactionID:r0355
is_a: GO:0008172 ! S-methyltransferase activity
is_a: GO:0042086 ! 5-methyl-5,6,7,8-tetrahydromethanopterin-dependent methyltransferase activity

[Term]
id: GO:0030270
name: formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity
namespace: molecular_function
alt_id: GO:0018714
def: "Catalysis of the reaction: 5,6,7,8-tetrahydromethanopterin + N-formylmethanofuran + H(+) = N(5)-formyl-5,6,7,8-tetrahydromethanopterin + methanofuran." [EC:2.3.1.101, RHEA:18064]
subset: gosubset_prok
synonym: "formylmethanofuran-tetrahydromethanopterin formyltransferase activity" EXACT [EC:2.3.1.101]
synonym: "formylmethanofuran:5,6,7,8-tetrahydromethanopterin 5-formyltransferase activity" EXACT [EC:2.3.1.101]
synonym: "formylmethanofuran:5,6,7,8-tetrahydromethanopterin N5-formyltransferase activity" EXACT [EC:2.3.1.101]
synonym: "formylmethanofuran:tetrahydromethanopterin formyltransferase activity" EXACT [EC:2.3.1.101]
synonym: "FTR" RELATED [EC:2.3.1.101]
synonym: "N-formylmethanofuran(CHO-MFR):tetrahydromethanopterin(H4MPT) formyltransferase activity" EXACT [EC:2.3.1.101]
xref: EC:2.3.1.101
xref: KEGG:R03390
xref: MetaCyc:2.3.1.101-RXN
xref: RHEA:18064
xref: UM-BBD_reactionID:r0346
is_a: GO:0016410 ! N-acyltransferase activity

[Term]
id: GO:0030271
name: obsolete chymase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the preferential cleavage: Phe-Xaa > Tyr-Xaa > Trp-Xaa > Leu-Xaa." [EC:3.4.21.39]
comment: This term was made obsolete because it represents a gene product.
synonym: "chymase activity" EXACT []
synonym: "mast cell protease I activity" NARROW [EC:3.4.21.39]
synonym: "mast cell serine proteinase" NARROW [EC:3.4.21.39]
synonym: "SK protease activity" EXACT [EC:3.4.21.39]
synonym: "skeletal muscle (SK) protease activity" NARROW [EC:3.4.21.39]
synonym: "skeletal muscle protease" NARROW [EC:3.4.21.39]
synonym: "skin chymotryptic proteinase" NARROW [EC:3.4.21.39]
xref: EC:3.4.21.39
xref: MetaCyc:3.4.21.39-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0030272
name: 5-formyltetrahydrofolate cyclo-ligase activity
namespace: molecular_function
alt_id: GO:0019006
def: "Catalysis of the reaction: 5-formyltetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + H(+) + phosphate." [EC:6.3.3.2, RHEA:10491]
subset: gosubset_prok
synonym: "5,10-methenyltetrahydrofolate synthetase activity" EXACT [EC:6.3.3.2]
synonym: "5-formyltetrahydrofolate cyclo-ligase (ADP-forming)" EXACT [EC:6.3.3.2]
synonym: "5-formyltetrahydrofolate cyclodehydrase" BROAD [EC:6.3.3.2]
synonym: "5-Formyltetrahydrofolate cyclodehydrase activity" EXACT [EC:6.3.3.2]
synonym: "formyltetrahydrofolic cyclodehydrase activity" EXACT [EC:6.3.3.2]
synonym: "methenyl-THF synthetase activity" EXACT [EC:6.3.3.2]
xref: EC:6.3.3.2
xref: KEGG:R02301
xref: MetaCyc:5-FORMYL-THF-CYCLO-LIGASE-RXN
xref: RHEA:10491
is_a: GO:0016882 ! cyclo-ligase activity

[Term]
id: GO:0030273
name: melanin-concentrating hormone receptor activity
namespace: molecular_function
def: "Combining with the cyclic peptide hormone melanin-concentrating hormone to initiate a change in cell activity." [GOC:mah]
synonym: "MCH receptor" EXACT []
is_a: GO:0016500 ! protein-hormone receptor activity

[Term]
id: GO:0030274
name: LIM domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a LIM domain (for Lin-11 Isl-1 Mec-3) of a protein, a domain with seven conserved cysteine residues and a histidine, that binds two zinc ions and acts as an interface for protein-protein interactions." [GOC:go_curators, Pfam:PF00412]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0030275
name: LRR domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a LRR domain (leucine rich repeats) of a protein." [GOC:go_curators, Pfam:PF00560]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0030276
name: clathrin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles." [GOC:jl, GOC:mah, ISBN:0198506732]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0030277
name: maintenance of gastrointestinal epithelium
namespace: biological_process
def: "Protection of epithelial surfaces of the gastrointestinal tract from proteolytic and caustic digestive agents." [GOC:mah]
is_a: GO:0010669 ! epithelial structure maintenance
is_a: GO:0022600 ! digestive system process

[Term]
id: GO:0030278
name: regulation of ossification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of bone formation." [GOC:go_curators]
synonym: "regulation of bone biosynthesis" EXACT []
synonym: "regulation of bone formation" EXACT []
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001503 ! ossification
relationship: regulates GO:0001503 ! ossification

[Term]
id: GO:0030279
name: negative regulation of ossification
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of bone formation." [GOC:go_curators]
synonym: "down regulation of ossification" EXACT []
synonym: "down-regulation of ossification" EXACT []
synonym: "downregulation of ossification" EXACT []
synonym: "inhibition of ossification" NARROW []
synonym: "negative regulation of bone biosynthesis" EXACT []
synonym: "negative regulation of bone formation" EXACT []
is_a: GO:0030278 ! regulation of ossification
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001503 ! ossification
relationship: negatively_regulates GO:0001503 ! ossification

[Term]
id: GO:0030280
name: structural constituent of epidermis
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of an epidermal cutaneous structure." [GOC:mah]
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0030281
name: structural constituent of cutaneous appendage
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of cutaneous epidermal structures such as hairs, scales, or feathers." [GOC:mah, ISBN:0878932437]
is_a: GO:0030280 ! structural constituent of epidermis

[Term]
id: GO:0030282
name: bone mineralization
namespace: biological_process
def: "The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue." [GOC:mah, PMID:22936354]
synonym: "bone calcification" NARROW []
is_a: GO:0031214 ! biomineral tissue development
relationship: part_of GO:0001503 ! ossification

[Term]
id: GO:0030283
name: testosterone dehydrogenase [NAD(P)] activity
namespace: molecular_function
def: "Catalysis of the reaction: testosterone + NAD(P)+ = androst-4-ene-3,17-dione + NAD(P)H + H+." [EC:1.1.1.51]
subset: gosubset_prok
synonym: "17beta-hydroxy steroid dehydrogenase" BROAD [EC:1.1.1.51]
synonym: "3(or 17)beta-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.51]
synonym: "3(or 17)beta-hydroxysteroid:NAD(P)+ oxidoreductase" BROAD [EC:1.1.1.51]
synonym: "3beta-hydroxy steroid dehydrogenase" BROAD [EC:1.1.1.51]
synonym: "3beta-hydroxysteroid dehydrogenase" BROAD [EC:1.1.1.51]
synonym: "beta-hydroxy steroid dehydrogenase" BROAD [EC:1.1.1.51]
xref: EC:1.1.1.51
xref: MetaCyc:1.1.1.51-RXN
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0030284
name: estrogen receptor activity
namespace: molecular_function
def: "Combining with estrogen and transmitting the signal within the cell to trigger a change in cell activity or function." [GOC:signaling, PMID:17615392]
comment: For estrogen receptors that function within the nucleus to modulate transcription, consider instead annotating to the child terms 'estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity ; GO:0038052' or 'estrogen-activated RNA polymerase II transcription factor binding transcription factor activity ; GO:0038053'.
is_a: GO:0003707 ! steroid hormone receptor activity

[Term]
id: GO:0030285
name: integral component of synaptic vesicle membrane
namespace: cellular_component
def: "The component of the synaptic vesicle membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
subset: goslim_synapse
synonym: "integral to synaptic vesicle membrane" NARROW []
is_a: GO:0031301 ! integral component of organelle membrane
is_a: GO:0044433 ! cytoplasmic vesicle part
is_a: GO:0044456 ! synapse part
is_a: GO:0097458 ! neuron part
intersection_of: GO:0016021 ! integral component of membrane
intersection_of: part_of GO:0008021 ! synaptic vesicle
relationship: part_of GO:0008021 ! synaptic vesicle

[Term]
id: GO:0030286
name: dynein complex
namespace: cellular_component
def: "Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]
is_a: GO:0005875 ! microtubule associated complex
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0030287
name: cell wall-bounded periplasmic space
namespace: cellular_component
def: "The region between the plasma membrane and the cell wall in organisms lacking an outer cell membrane such as yeast and Gram positive bacteria. The region is thinner than the equivalent in Gram negative bacteria." [GOC:mlg, GOC:mtg_sensu]
subset: gosubset_prok
synonym: "cell wall bounded periplasmic space" EXACT []
synonym: "cell wall-enclosed periplasmic space" EXACT []
synonym: "inner wall zone" NARROW [GOC:bf, GOC:md, Wikipedia:Periplasmic_space]
synonym: "IWZ" NARROW [GOC:bf, GOC:md, Wikipedia:Periplasmic_space]
is_a: GO:0042597 ! periplasmic space

[Term]
id: GO:0030288
name: outer membrane-bounded periplasmic space
namespace: cellular_component
def: "The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall." [GOC:mlg, GOC:mtg_sensu]
subset: gosubset_prok
synonym: "outer membrane bounded periplasmic space" EXACT []
synonym: "outer membrane-enclosed periplasmic space" EXACT []
xref: Wikipedia:Periplasmic_space
is_a: GO:0042597 ! periplasmic space
relationship: part_of GO:0030313 ! cell envelope

[Term]
id: GO:0030289
name: protein phosphatase 4 complex
namespace: cellular_component
def: "A protein serine/threonine phosphatase complex formed by the catalytic subunit of protein phosphatase 4 plus one or more regulatory subunits." [GOC:bm, PMID:10026142]
is_a: GO:0008287 ! protein serine/threonine phosphatase complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0030290
name: sphingolipid activator protein activity
namespace: molecular_function
def: "Any of a group of peptide cofactors of enzymes for the lysosomal degradation of sphingolipids. They stimulate various enzymes, including glucosylceramidase, galactosylceramidase, cerebroside-sulfatase, alpha-galactosidase, beta-galactosidase, and sphingomyelin phosphodiesterase." [ISBN:0198506732]
synonym: "saposin" NARROW []
xref: Reactome:REACT_115670 "Ganglioside GM2 activator presents GM2 to hexosaminidase for cleavage, Homo sapiens"
is_a: GO:0008047 ! enzyme activator activity

[Term]
id: GO:0030291
name: protein serine/threonine kinase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a protein serine/threonine kinase." [GOC:mah]
is_a: GO:0004860 ! protein kinase inhibitor activity
relationship: negatively_regulates GO:0004674 ! protein serine/threonine kinase activity
relationship: part_of GO:0071901 ! negative regulation of protein serine/threonine kinase activity

[Term]
id: GO:0030292
name: protein tyrosine kinase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a protein tyrosine kinase." [GOC:mah]
is_a: GO:0004860 ! protein kinase inhibitor activity
relationship: part_of GO:0061099 ! negative regulation of protein tyrosine kinase activity

[Term]
id: GO:0030293
name: transmembrane receptor protein tyrosine kinase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a transmembrane receptor protein tyrosine kinase." [GOC:mah]
is_a: GO:0030292 ! protein tyrosine kinase inhibitor activity
is_a: GO:0030547 ! receptor inhibitor activity
relationship: negatively_regulates GO:0004714 ! transmembrane receptor protein tyrosine kinase activity

[Term]
id: GO:0030294
name: receptor signaling protein tyrosine kinase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a receptor signaling protein tyrosine kinase." [GOC:mah]
synonym: "receptor signalling protein tyrosine kinase inhibitor activity" EXACT []
is_a: GO:0030292 ! protein tyrosine kinase inhibitor activity
relationship: negatively_regulates GO:0004716 ! receptor signaling protein tyrosine kinase activity

[Term]
id: GO:0030295
name: protein kinase activator activity
namespace: molecular_function
def: "Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai]
subset: gosubset_prok
is_a: GO:0019209 ! kinase activator activity
is_a: GO:0019887 ! protein kinase regulator activity
relationship: part_of GO:0032147 ! activation of protein kinase activity
relationship: positively_regulates GO:0004672 ! protein kinase activity

[Term]
id: GO:0030296
name: protein tyrosine kinase activator activity
namespace: molecular_function
def: "Increases the activity of a protein tyrosine kinase, an enzyme which phosphorylates a tyrosyl phenolic group on a protein." [GOC:ai, ISBN:0198506732]
is_a: GO:0030295 ! protein kinase activator activity
relationship: part_of GO:0061098 ! positive regulation of protein tyrosine kinase activity

[Term]
id: GO:0030297
name: transmembrane receptor protein tyrosine kinase activator activity
namespace: molecular_function
def: "Binds to and increases the activity of a transmembrane receptor protein tyrosine kinase." [GOC:mah]
is_a: GO:0004871 ! signal transducer activity
is_a: GO:0030296 ! protein tyrosine kinase activator activity
is_a: GO:0030546 ! receptor activator activity
relationship: part_of GO:0007171 ! activation of transmembrane receptor protein tyrosine kinase activity
relationship: positively_regulates GO:0004714 ! transmembrane receptor protein tyrosine kinase activity

[Term]
id: GO:0030298
name: receptor signaling protein tyrosine kinase activator activity
namespace: molecular_function
def: "Binds to and increases the activity of a receptor signaling protein tyrosine kinase." [GOC:mah]
synonym: "receptor signalling protein tyrosine kinase activator activity" EXACT []
is_a: GO:0030296 ! protein tyrosine kinase activator activity
relationship: positively_regulates GO:0004716 ! receptor signaling protein tyrosine kinase activity

[Term]
id: GO:0030299
name: intestinal cholesterol absorption
namespace: biological_process
def: "Uptake of cholesterol into the blood by absorption from the small intestine." [GOC:mah]
is_a: GO:0030301 ! cholesterol transport
is_a: GO:0098856 ! intestinal lipid absorption
relationship: part_of GO:0044241 ! lipid digestion

[Term]
id: GO:0030300
name: regulation of intestinal cholesterol absorption
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of absorption of cholesterol into the blood, and the exclusion of other sterols from absorption." [GOC:mah, PMID:11099417]
is_a: GO:0032374 ! regulation of cholesterol transport
is_a: GO:1904729 ! regulation of intestinal lipid absorption
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030299 ! intestinal cholesterol absorption
relationship: regulates GO:0030299 ! intestinal cholesterol absorption

[Term]
id: GO:0030301
name: cholesterol transport
namespace: biological_process
def: "The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah, ISBN:0198506732]
is_a: GO:0015918 ! sterol transport

[Term]
id: GO:0030302
name: deoxynucleotide transport
namespace: biological_process
def: "The directed movement of a deoxynucleotide, a deoxyribonucleoside in ester linkage to phosphate, commonly at the 5' position of deoxyribose, into, out of or within a cell." [GOC:mah, ISBN:0198506732]
is_a: GO:0006862 ! nucleotide transport
is_a: GO:1901264 ! carbohydrate derivative transport

[Term]
id: GO:0030303
name: obsolete stromelysin 2 activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of peptide bonds in collagen with preferential cleavage where P1', P2' and P3' are hydrophobic residues; action on collagen types III, IV and V is weak." [EC:3.4.24.17, EC:3.4.24.22]
comment: This term was made obsolete because it represents a gene product.
synonym: "matrix metalloproteinase 10 activity" EXACT [EC:3.4.24.22]
synonym: "MMP-10" EXACT []
synonym: "proteoglycanase 2" RELATED [EC:3.4.24.22]
synonym: "stromelysin 2 activity" EXACT []
synonym: "transin 2 activity" EXACT [EC:3.4.24.22]
xref: EC:3.4.24.22
xref: MetaCyc:3.4.24.22-RXN
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0030304
name: obsolete trypsin inhibitor activity
namespace: molecular_function
def: "OBSOLETE. Stops, prevents or reduces the activity of the serine endopeptidase trypsin." [GOC:ai]
comment: This term was made obsolete because it represents a regulator of an obsolete molecular function.
subset: gosubset_prok
synonym: "trypsin inhibitor activity" EXACT []
is_obsolete: true
replaced_by: GO:0004867

[Term]
id: GO:0030305
name: heparanase activity
namespace: molecular_function
def: "Catalysis of the cleavage of heparan sulfate; can degrade both heparan sulfate and heparin glycosaminoglycan chains." [PMID:10916150]
synonym: "heparinase activity" RELATED []
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0030306
name: ADP-ribosylation factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with ARF, ADP-ribosylation factor, a small monomeric cytosolic GTPase that, when bound to GTP, binds to the membranes of cells." [ISBN:0198506732]
synonym: "ARF binding" EXACT []
is_a: GO:0031267 ! small GTPase binding

[Term]
id: GO:0030307
name: positive regulation of cell growth
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, extent or direction of cell growth." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of cell growth" NARROW []
synonym: "stimulation of cell growth" NARROW []
synonym: "up regulation of cell growth" EXACT []
synonym: "up-regulation of cell growth" EXACT []
synonym: "upregulation of cell growth" EXACT []
is_a: GO:0001558 ! regulation of cell growth
is_a: GO:0045927 ! positive regulation of growth
is_a: GO:0048522 ! positive regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016049 ! cell growth
relationship: positively_regulates GO:0016049 ! cell growth

[Term]
id: GO:0030308
name: negative regulation of cell growth
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of cell growth" EXACT []
synonym: "down-regulation of cell growth" EXACT []
synonym: "downregulation of cell growth" EXACT []
synonym: "inhibition of cell growth" NARROW []
xref: Reactome:REACT_6328 "DRheb is inhibited by the TSC1/2 complex, Drosophila melanogaster"
is_a: GO:0001558 ! regulation of cell growth
is_a: GO:0045926 ! negative regulation of growth
is_a: GO:0048523 ! negative regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016049 ! cell growth
relationship: negatively_regulates GO:0016049 ! cell growth

[Term]
id: GO:0030309
name: poly-N-acetyllactosamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n." [GOC:mah, PMID:9405606]
subset: gosubset_prok
synonym: "poly-N-acetyllactosamine metabolism" EXACT []
is_a: GO:0006022 ! aminoglycan metabolic process
is_a: GO:0044264 ! cellular polysaccharide metabolic process

[Term]
id: GO:0030310
name: poly-N-acetyllactosamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n." [GOC:mah, PMID:9405606]
subset: gosubset_prok
synonym: "poly-N-acetyllactosamine breakdown" EXACT []
synonym: "poly-N-acetyllactosamine catabolism" EXACT []
synonym: "poly-N-acetyllactosamine degradation" EXACT []
is_a: GO:0006026 ! aminoglycan catabolic process
is_a: GO:0030309 ! poly-N-acetyllactosamine metabolic process
is_a: GO:0044247 ! cellular polysaccharide catabolic process

[Term]
id: GO:0030311
name: poly-N-acetyllactosamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n." [GOC:mah, PMID:9405606]
subset: gosubset_prok
synonym: "poly-N-acetyllactosamine anabolism" EXACT []
synonym: "poly-N-acetyllactosamine biosynthesis" EXACT []
synonym: "poly-N-acetyllactosamine formation" EXACT []
synonym: "poly-N-acetyllactosamine synthesis" EXACT []
is_a: GO:0006023 ! aminoglycan biosynthetic process
is_a: GO:0030309 ! poly-N-acetyllactosamine metabolic process
is_a: GO:0033692 ! cellular polysaccharide biosynthetic process

[Term]
id: GO:0030312
name: external encapsulating structure
namespace: cellular_component
def: "A structure that lies outside the plasma membrane and surrounds the entire cell. This does not include the periplasmic space." [GOC:go_curators]
comment: The outer membrane (of gram negative bacteria) or cell wall (of yeast or Gram positive bacteria) are defined as parts of this structure, see 'external encapsulating structure part'.
subset: goslim_chembl
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
is_a: GO:0044464 ! cell part
relationship: part_of GO:0071944 ! cell periphery

[Term]
id: GO:0030313
name: cell envelope
namespace: cellular_component
def: "An envelope that surrounds a bacterial cell and includes the cytoplasmic membrane and everything external, encompassing the periplasmic space, cell wall, and outer membrane if present." [GOC:ds, GOC:mlg, http://pathmicro.med.sc.edu/fox/cell_envelope.htm]
subset: goslim_pir
subset: gosubset_prok
xref: Wikipedia:Cell_envelope
is_a: GO:0031975 ! envelope
relationship: has_part GO:0005886 ! plasma membrane

[Term]
id: GO:0030314
name: junctional membrane complex
namespace: cellular_component
def: "Complex formed in muscle cells between the membrane of the sarcoplasmic reticulum and invaginations of the plasma membrane (T-tubules)." [PMID:11535622]
synonym: "triad junction" BROAD []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0016528 ! sarcoplasm

[Term]
id: GO:0030315
name: T-tubule
namespace: cellular_component
def: "Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane." [GOC:mtg_muscle, ISBN:0815316194]
synonym: "transverse tubule" EXACT []
synonym: "triad" RELATED []
xref: Wikipedia:T-tubule
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0042383 ! sarcolemma

[Term]
id: GO:0030316
name: osteoclast differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue." [CL:0000092, GOC:add, ISBN:0781735149, PMID:12161749]
synonym: "osteoclast cell differentiation" EXACT []
is_a: GO:0002573 ! myeloid leukocyte differentiation

[Term]
id: GO:0030317
name: sperm motility
namespace: biological_process
def: "Any process involved in the controlled movement of a sperm cell." [GOC:jl]
synonym: "sperm movement" EXACT []
xref: Wikipedia:Sperm_motility
is_a: GO:0048870 ! cell motility

[Term]
id: GO:0030318
name: melanocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a melanocyte." [GOC:mah]
synonym: "melanocyte cell differentiation" EXACT []
synonym: "melanophore differentiation" EXACT []
is_a: GO:0050931 ! pigment cell differentiation
is_a: GO:0060563 ! neuroepithelial cell differentiation

[Term]
id: GO:0030319
name: obsolete cellular di-, tri-valent inorganic anion homeostasis
namespace: biological_process
def: "OBSOLETE. Any process involved in the maintenance of an internal steady state of divalent or trivalent inorganic anions at the level of a cell." [GOC:ai, GOC:mah]
comment: This term was made obsolete because it has been split.
synonym: "cellular di-, tri-valent inorganic anion homeostasis" EXACT []
is_obsolete: true
consider: GO:0072501
consider: GO:0072502

[Term]
id: GO:0030320
name: cellular monovalent inorganic anion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of monovalent inorganic anions at the level of a cell." [GOC:ai, GOC:mah]
is_a: GO:0030002 ! cellular anion homeostasis
is_a: GO:0055083 ! monovalent inorganic anion homeostasis

[Term]
id: GO:0030321
name: transepithelial chloride transport
namespace: biological_process
def: "The directed movement of chloride ions from one side of an epithelium to the other." [GOC:mah]
is_a: GO:0006821 ! chloride transport
is_a: GO:0070633 ! transepithelial transport

[Term]
id: GO:0030322
name: stabilization of membrane potential
namespace: biological_process
def: "The accomplishment of a non-fluctuating membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, ISBN:0198506732]
is_a: GO:0042391 ! regulation of membrane potential

[Term]
id: GO:0030323
name: respiratory tube development
namespace: biological_process
def: "The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract." [GOC:jid]
is_a: GO:0035295 ! tube development
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048513 ! animal organ development

[Term]
id: GO:0030324
name: lung development
namespace: biological_process
def: "The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax." [GOC:jid, UBERON:0002048]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048513 ! animal organ development
relationship: part_of GO:0030323 ! respiratory tube development
relationship: part_of GO:0060541 ! respiratory system development

[Term]
id: GO:0030325
name: adrenal gland development
namespace: biological_process
def: "The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells." [GOC:dgh]
synonym: "interrenal gland" RELATED []
is_a: GO:0048732 ! gland development
relationship: part_of GO:0035270 ! endocrine system development

[Term]
id: GO:0030326
name: embryonic limb morphogenesis
namespace: biological_process
def: "The process, occurring in the embryo, by which the anatomical structures of the limb are generated and organized. A limb is an appendage of an animal used for locomotion or grasping." [GOC:bf, GOC:jl, ISBN:0395825172]
is_a: GO:0035108 ! limb morphogenesis
is_a: GO:0035113 ! embryonic appendage morphogenesis

[Term]
id: GO:0030327
name: prenylated protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of prenylated proteins." [GOC:mah]
subset: gosubset_prok
synonym: "prenylated protein breakdown" EXACT []
synonym: "prenylated protein catabolism" EXACT []
synonym: "prenylated protein degradation" EXACT []
is_a: GO:0019941 ! modification-dependent protein catabolic process

[Term]
id: GO:0030328
name: prenylcysteine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue." [GOC:ai]
subset: gosubset_prok
synonym: "prenylcysteine breakdown" EXACT []
synonym: "prenylcysteine catabolism" EXACT []
synonym: "prenylcysteine degradation" EXACT []
is_a: GO:0000098 ! sulfur amino acid catabolic process
is_a: GO:0030329 ! prenylcysteine metabolic process
is_a: GO:0042219 ! cellular modified amino acid catabolic process

[Term]
id: GO:0030329
name: prenylcysteine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue." [GOC:ai, PMID:16627894]
subset: gosubset_prok
synonym: "prenylcysteine metabolism" EXACT []
is_a: GO:0000096 ! sulfur amino acid metabolic process
is_a: GO:0006575 ! cellular modified amino acid metabolic process

[Term]
id: GO:0030330
name: DNA damage response, signal transduction by p53 class mediator
namespace: biological_process
alt_id: GO:0006976
def: "A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage." [GOC:go_curators]
synonym: "DNA damage response, activation of p53" RELATED []
synonym: "p53 signaling pathway" RELATED [GOC:mah, GOC:vk]
synonym: "p53-mediated DNA damage response" BROAD []
synonym: "TP53 signaling pathway" RELATED [GOC:mah, GOC:vk]
is_a: GO:0042770 ! signal transduction in response to DNA damage
is_a: GO:0072331 ! signal transduction by p53 class mediator

[Term]
id: GO:0030331
name: estrogen receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an estrogen receptor." [GOC:ai]
is_a: GO:0035258 ! steroid hormone receptor binding

[Term]
id: GO:0030332
name: cyclin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis." [GOC:ai]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0030334
name: regulation of cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell migration." [GOC:go_curators]
is_a: GO:2000145 ! regulation of cell motility
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016477 ! cell migration
relationship: regulates GO:0016477 ! cell migration

[Term]
id: GO:0030335
name: positive regulation of cell migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell migration." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of cell migration" NARROW []
synonym: "stimulation of cell migration" NARROW []
synonym: "up regulation of cell migration" EXACT []
synonym: "up-regulation of cell migration" EXACT []
synonym: "upregulation of cell migration" EXACT []
is_a: GO:0030334 ! regulation of cell migration
is_a: GO:2000147 ! positive regulation of cell motility
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016477 ! cell migration
relationship: positively_regulates GO:0016477 ! cell migration

[Term]
id: GO:0030336
name: negative regulation of cell migration
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration." [GOC:go_curators]
synonym: "down regulation of cell migration" EXACT []
synonym: "down-regulation of cell migration" EXACT []
synonym: "downregulation of cell migration" EXACT []
synonym: "inhibition of cell migration" NARROW []
is_a: GO:0030334 ! regulation of cell migration
is_a: GO:2000146 ! negative regulation of cell motility
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016477 ! cell migration
relationship: negatively_regulates GO:0016477 ! cell migration

[Term]
id: GO:0030337
name: DNA polymerase processivity factor activity
namespace: molecular_function
def: "An enzyme regulator activity that increases the processivity of polymerization by DNA polymerase, by allowing the polymerase to move rapidly along DNA while remaining topologically bound to it." [GOC:mah, PMID:7903401, PMID:8087839]
subset: gosubset_prok
synonym: "processivity clamp" EXACT []
synonym: "sliding clamp" NARROW [GOC:jh2, PMID:23012374]
is_a: GO:0030234 ! enzyme regulator activity
relationship: part_of GO:0006259 ! DNA metabolic process

[Term]
id: GO:0030338
name: CMP-N-acetylneuraminate monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: CMP-N-acetylneuraminate + NADPH + H+ + O2 = CMP-N-glycoloylneuraminate + NADP+ + H2O." [EC:1.14.18.2]
comment: Note that this was EC:1.14.13.45.
synonym: "CMP-N-acetylneuraminate hydroxylase activity" EXACT [EC:1.14.18.2]
synonym: "CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating)" EXACT [EC:1.14.18.2]
synonym: "CMP-N-acetylneuraminic acid hydroxylase activity" EXACT []
synonym: "CMP-Neu5Ac hydroxylase activity" EXACT [EC:1.14.18.2]
synonym: "cytidine monophosphoacetylneuraminate monooxygenase activity" EXACT [EC:1.14.18.2]
synonym: "cytidine-5'-monophosphate-N-acetylneuraminic acid hydroxylase activity" EXACT [EC:1.14.18.2]
synonym: "N-acetylneuraminic monooxygenase activity" EXACT [EC:1.14.18.2]
xref: EC:1.14.18.2
xref: MetaCyc:1.14.13.45-RXN
is_a: GO:0016716 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0030339
name: fatty-acyl-ethyl-ester synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: a long-chain-acyl ethyl ester + H2O = a long-chain carboxylic acid + ethanol." [EC:3.1.1.67]
synonym: "FAEE synthase activity" EXACT [EC:3.1.1.67]
synonym: "FAEES activity" EXACT [EC:3.1.1.67]
synonym: "fatty-acyl ethyl ester synthase" EXACT [GOC:mah]
synonym: "long-chain-fatty-acyl-ethyl-ester acylhydrolase activity" EXACT [EC:3.1.1.67]
xref: EC:3.1.1.67
xref: MetaCyc:FATTY-ACYL-ETHYL-ESTER-SYNTHASE-RXN
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0030340
name: hyaluronate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: hyaluronate = n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine." [EC:4.2.2.1]
subset: gosubset_prok
synonym: "glucuronoglycosaminoglycan lyase activity" EXACT [EC:4.2.2.1]
synonym: "hyaluronidase [but cf. EC 3.2.1.35 (hyalurononglucosaminidase) and EC 3.2.1.36 (hyaluronoglucuronidase)]" RELATED [EC:4.2.2.1]
synonym: "hyaluronidase activity" BROAD [EC:4.2.2.1]
synonym: "mucinase activity" EXACT [EC:4.2.2.1]
synonym: "spreading factor activity" RELATED [EC:4.2.2.1]
xref: EC:4.2.2.1
xref: MetaCyc:HYALURONATE-LYASE-RXN
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0030341
name: chondroitin AC lyase activity
namespace: molecular_function
def: "Catalysis of the eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups." [EC:4.2.2.5]
subset: gosubset_prok
synonym: "ChnAC" RELATED []
synonym: "chondroitin AC eliminase activity" EXACT [EC:4.2.2.5]
synonym: "chondroitin lyase activity" EXACT []
synonym: "chondroitin sulfate lyase activity" EXACT [EC:4.2.2.5]
synonym: "chondroitinase AC" RELATED []
synonym: "chondroitinase activity" BROAD []
xref: EC:4.2.2.5
xref: MetaCyc:4.2.2.5-RXN
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0030342
name: 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the hydroxylation of C-24 of 1-alpha,25-hydroxycholecalciferol (25-hydroxyvitamin D3; calcitriol)." [PMID:8506296]
synonym: "1,25-(OH)2D3 24-hydroxylase activity" EXACT [PMID:8506296]
synonym: "calcitriol 24-hydroxylase activity" EXACT [CHEBI:17823, GOC:mah]
xref: Reactome:REACT_101028 "CYP24A1 catalyzes the initial step in the deactivation of the hormonally active form of vitamin D3, Taeniopygia guttata"
xref: Reactome:REACT_101320 "CYP24A1 catalyzes the initial step in the deactivation of the hormonally active form of vitamin D3, Xenopus tropicalis"
xref: Reactome:REACT_101976 "1,25-dihydroxyvitamin D3 is deactivated, Rattus norvegicus"
xref: Reactome:REACT_102167 "CYP24A1 catalyzes the initial step in the deactivation of the hormonally active form of vitamin D3, Bos taurus"
xref: Reactome:REACT_104054 "1,25-dihydroxyvitamin D3 is deactivated, Bos taurus"
xref: Reactome:REACT_109386 "1,25-dihydroxyvitamin D3 is deactivated, Xenopus tropicalis"
xref: Reactome:REACT_109452 "1,25-dihydroxyvitamin D3 is deactivated, Canis familiaris"
xref: Reactome:REACT_13667 "1,25-dihydroxyvitamin D3 is deactivated, Homo sapiens"
xref: Reactome:REACT_13822 "CYP24A1 catalyzes the initial step in the deactivation of the hormonally active form of vitamin D3, Homo sapiens"
xref: Reactome:REACT_32640 "1,25-dihydroxyvitamin D3 is deactivated, Gallus gallus"
xref: Reactome:REACT_34208 "1,25-dihydroxyvitamin D3 is deactivated, Taeniopygia guttata"
xref: Reactome:REACT_34353 "CYP24A1 catalyzes the initial step in the deactivation of the hormonally active form of vitamin D3, Drosophila melanogaster"
xref: Reactome:REACT_78936 "CYP24A1 catalyzes the initial step in the deactivation of the hormonally active form of vitamin D3, Rattus norvegicus"
xref: Reactome:REACT_79326 "1,25-dihydroxyvitamin D3 is deactivated, Danio rerio"
xref: Reactome:REACT_80980 "CYP24A1 catalyzes the initial step in the deactivation of the hormonally active form of vitamin D3, Canis familiaris"
xref: Reactome:REACT_85182 "1,25-dihydroxyvitamin D3 is deactivated, Sus scrofa"
xref: Reactome:REACT_88377 "1,25-dihydroxyvitamin D3 is deactivated, Mus musculus"
xref: Reactome:REACT_88922 "CYP24A1 catalyzes the initial step in the deactivation of the hormonally active form of vitamin D3, Mus musculus"
xref: Reactome:REACT_94179 "1,25-dihydroxyvitamin D3 is deactivated, Drosophila melanogaster"
xref: Reactome:REACT_98433 "CYP24A1 catalyzes the initial step in the deactivation of the hormonally active form of vitamin D3, Gallus gallus"
xref: Reactome:REACT_98444 "CYP24A1 catalyzes the initial step in the deactivation of the hormonally active form of vitamin D3, Danio rerio"
xref: Reactome:REACT_99877 "CYP24A1 catalyzes the initial step in the deactivation of the hormonally active form of vitamin D3, Sus scrofa"
is_a: GO:0070576 ! vitamin D 24-hydroxylase activity

[Term]
id: GO:0030343
name: vitamin D3 25-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: vitamin D3 + NADPH + H+ + O2 = calcidiol + NADP+ + H2O." [ISBN:0471331309, MetaCyc:RXN-9829]
synonym: "cholecalciferol 25-hydroxylase activity" EXACT []
xref: MetaCyc:RXN-9829
xref: Reactome:REACT_102234 "25-Hydroxylation of vitamin D3 in liver, Danio rerio"
xref: Reactome:REACT_13458 "25-Hydroxylation of vitamin D3 in liver, Homo sapiens"
xref: Reactome:REACT_28168 "25-Hydroxylation of vitamin D3 in liver, Xenopus tropicalis"
xref: Reactome:REACT_32506 "25-Hydroxylation of vitamin D3 in liver, Mus musculus"
xref: Reactome:REACT_79485 "25-Hydroxylation of vitamin D3 in liver, Sus scrofa"
xref: Reactome:REACT_87444 "25-Hydroxylation of vitamin D3 in liver, Rattus norvegicus"
xref: Reactome:REACT_88533 "25-Hydroxylation of vitamin D3 in liver, Bos taurus"
xref: Reactome:REACT_89571 "25-Hydroxylation of vitamin D3 in liver, Taeniopygia guttata"
xref: Reactome:REACT_90307 "25-Hydroxylation of vitamin D3 in liver, Canis familiaris"
xref: Reactome:REACT_95290 "25-Hydroxylation of vitamin D3 in liver, Gallus gallus"
is_a: GO:0070643 ! vitamin D 25-hydroxylase activity
relationship: part_of GO:0036378 ! calcitriol biosynthetic process from calciol

[Term]
id: GO:0030345
name: structural constituent of tooth enamel
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of tooth enamel." [GOC:mah]
is_a: GO:0030021 ! extracellular matrix structural constituent conferring compression resistance

[Term]
id: GO:0030346
name: protein phosphatase 2B binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the enzyme protein phosphatase 2B." [GOC:jl]
synonym: "calcineurin binding" EXACT []
synonym: "protein phosphatase 3 binding" RELATED [GOC:dph, GOC:rl]
is_a: GO:0019903 ! protein phosphatase binding

[Term]
id: GO:0030348
name: syntaxin-3 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the SNAP receptor syntaxin-3." [GOC:ai]
is_a: GO:0019905 ! syntaxin binding

[Term]
id: GO:0030350
name: iron-responsive element binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the iron-responsive element, a regulatory sequence found in the 5'- and 3'-untranslated regions of mRNAs encoding many iron-binding proteins." [PMID:3198610, PMID:8710843]
synonym: "IRE binding" EXACT []
is_a: GO:0003729 ! mRNA binding

[Term]
id: GO:0030351
name: inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: inositol-1,3,4,5,6-pentakisphosphate + H2O = inositol-1,4,5,6-tetrakisphosphate + phosphate." [GOC:ai]
xref: EC:3.1.3.-
is_a: GO:0052827 ! inositol pentakisphosphate phosphatase activity

[Term]
id: GO:0030352
name: inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: inositol-1,4,5,6-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate." [GOC:ai]
xref: EC:3.1.3.-
is_a: GO:0052743 ! inositol tetrakisphosphate phosphatase activity

[Term]
id: GO:0030353
name: fibroblast growth factor receptor antagonist activity
namespace: molecular_function
def: "Interacts with the fibroblast growth factor receptor to reduce the action of another ligand, the agonist." [GOC:mah]
synonym: "FGF receptor antagonist activity" EXACT []
synonym: "FGFR antagonist activity" EXACT []
is_a: GO:0005104 ! fibroblast growth factor receptor binding
is_a: GO:0048019 ! receptor antagonist activity
relationship: part_of GO:0040037 ! negative regulation of fibroblast growth factor receptor signaling pathway

[Term]
id: GO:0030354
name: melanin-concentrating hormone activity
namespace: molecular_function
def: "The action characteristic of melanin-concentrating hormone, a cyclic peptide hormone that, upon receptor binding, induces melanin aggregation in melanocytes, and is also involved in regulating food intake and energy balance in mammals." [GOC:mah, PMID:11416225, PMID:9792536]
is_a: GO:0005179 ! hormone activity

[Term]
id: GO:0030355
name: obsolete small nucleolar ribonucleoprotein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it describes a cellular component rather than a molecular function.
synonym: "small nucleolar ribonucleoprotein" EXACT []
synonym: "snoRNP" EXACT []
is_obsolete: true
replaced_by: GO:0005732

[Term]
id: GO:0030356
name: obsolete small cytoplasmic ribonucleoprotein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it describes a cellular component rather than a molecular function.
synonym: "scRNP" EXACT []
synonym: "small cytoplasmic ribonucleoprotein" EXACT []
is_obsolete: true
replaced_by: GO:0030531

[Term]
id: GO:0030359
name: protein phosphatase type 2B regulator activity
namespace: molecular_function
def: "Modulation of the activity of the enzyme protein phosphatase type 2B." [GOC:ai]
synonym: "calcineurin regulator activity" EXACT [GOC:dph, GOC:rl]
synonym: "calcineurin, intrinsic regulator activity" NARROW [GOC:dph, GOC:rl]
synonym: "protein phosphatase 3 regulator activity" RELATED [GOC:dph, GOC:rl]
synonym: "protein phosphatase 3, intrinsic regulator activity" RELATED [GOC:dph, GOC:rl]
synonym: "protein phosphatase type 2B, intrinsic regulator activity" NARROW []
is_a: GO:0019888 ! protein phosphatase regulator activity
relationship: has_part GO:0030346 ! protein phosphatase 2B binding

[Term]
id: GO:0030362
name: protein phosphatase type 4 regulator activity
namespace: molecular_function
def: "Modulation of the activity of the enzyme protein phosphatase type 4." [GOC:ai]
synonym: "protein phosphatase type 4, intrinsic regulator activity" NARROW []
is_a: GO:0019888 ! protein phosphatase regulator activity

[Term]
id: GO:0030363
name: obsolete pre-mRNA cleavage factor activity
namespace: molecular_function
def: "OBSOLETE. Any activity required for the process of mRNA cleavage." [GOC:mah, PMID:10357856]
comment: This term was made obsolete because it describes a biological process.
synonym: "pre-mRNA cleavage factor activity" EXACT []
is_obsolete: true
consider: GO:0006379

[Term]
id: GO:0030364
name: obsolete cleavage and polyadenylylation specificity factor activity
namespace: molecular_function
def: "OBSOLETE. A factor required in mRNA 3' end processing for both the cleavage and poly(A) addition reactions and, consistent with this function, recognizes AAUAAA, a signal also essential for both reactions." [PMID:10357856]
comment: This term was made obsolete because it describes a cellular component.
synonym: "cleavage and polyadenylation specificity factor activity" EXACT []
synonym: "cleavage and polyadenylylation specificity factor activity" EXACT []
synonym: "cleavage/polyadenylation specificity factor activity" EXACT []
synonym: "CPSF" EXACT []
is_obsolete: true
replaced_by: GO:0005847
consider: GO:0006378
consider: GO:0006379

[Term]
id: GO:0030365
name: obsolete cleavage stimulation factor activity
namespace: molecular_function
def: "OBSOLETE. A factor is necessary for cleavage but not for poly(A) addition in mRNA 3' end processing; can stimulate poly(A) addition on substrates with a CstF binding site upstream of the AAUAAA hexanucleotide." [PMID:10357856]
comment: This term was made obsolete because it describes a cellular component.
synonym: "cleavage stimulation factor activity" EXACT []
synonym: "CstF" EXACT []
is_obsolete: true
replaced_by: GO:0005848
consider: GO:0006379

[Term]
id: GO:0030366
name: molybdopterin synthase activity
namespace: molecular_function
def: "Catalysis of the conversion of precursor Z to molybdopterin, the final step in molybdopterin biosynthesis." [PMID:18154309, PMID:8514783]
xref: EC:2.8.1.12
xref: Reactome:REACT_25353 "Sulfhydrylation and ring cleavage of precursor Z, Homo sapiens"
is_a: GO:0016783 ! sulfurtransferase activity

[Term]
id: GO:0030367
name: interleukin-17 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-17 receptor." [GOC:ai]
synonym: "IL-17" NARROW []
synonym: "interleukin-17 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0030368
name: interleukin-17 receptor activity
namespace: molecular_function
def: "Combining with any member of the interleukin-17 family of cytokines and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:jl, GOC:signaling]
synonym: "IL-17 receptor activity" EXACT [GOC:mah]
synonym: "IL-17R" EXACT []
xref: Wikipedia:Interleukin-17_receptor
is_a: GO:0004896 ! cytokine receptor activity
relationship: has_part GO:0019975 ! interleukin-17 binding

[Term]
id: GO:0030369
name: ICAM-3 receptor activity
namespace: molecular_function
def: "Combining with ICAM-3, intercellular adhesion molecule 3, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. ICAM-3, or CD50, are constitutively expressed on monocytes, granulocytes and lymphocytes; on physiological stimulation, they become transiently phosphorylated on serine residues." [GOC:ai, GOC:signaling, ISBN:0198506732, PMID:7515813]
comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'cell adhesion molecule binding ; GO:0050839' and 'receptor binding ; GO:0005102' and the biological process term 'cell adhesion ; GO:0007155'.
is_a: GO:0004888 ! transmembrane signaling receptor activity

[Term]
id: GO:0030370
name: intercellular adhesion molecule-3 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with receptors for intercellular adhesion molecule-3 (ICAM-3), such as DC-SIGN and LFA-1." [GOC:ceb, PMID:11473836]
synonym: "ICAM-3 receptor binding" EXACT []
synonym: "ICAM-3 receptor ligand" NARROW []
synonym: "intercellular adhesion molecule-3 receptor ligand" NARROW []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0030371
name: translation repressor activity
namespace: molecular_function
def: "Antagonizes ribosome-mediated translation of mRNA into a polypeptide." [GOC:ai, GOC:clt]
is_a: GO:0045182 ! translation regulator activity
relationship: part_of GO:0017148 ! negative regulation of translation

[Term]
id: GO:0030372
name: high molecular weight B cell growth factor receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the high molecular weight B cell growth factor receptor." [GOC:ai]
synonym: "high molecular weight B cell growth factor receptor ligand" NARROW []
synonym: "high molecular weight B lymphocyte growth factor receptor binding" EXACT []
synonym: "high molecular weight B-cell growth factor receptor binding" EXACT []
synonym: "high molecular weight B-lymphocyte growth factor receptor binding" EXACT []
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0030373
name: high molecular weight B cell growth factor receptor activity
namespace: molecular_function
def: "Combining with a high molecular weight B cell growth factor and transmitting the signal to initiate a change in cell activity." [GOC:ai, GOC:signaling, PMID:2681271]
synonym: "high molecular weight B lymphocyte growth factor receptor activity" EXACT []
synonym: "high molecular weight B-cell growth factor receptor activity" EXACT []
synonym: "high molecular weight B-lymphocyte growth factor receptor activity" EXACT []
synonym: "HMW-BCGF receptor" EXACT [PMID:2681271]
is_a: GO:0038023 ! signaling receptor activity

[Term]
id: GO:0030374
name: ligand-dependent nuclear receptor transcription coactivator activity
namespace: molecular_function
def: "The function of a transcription cofactor that activates transcription in conjuction with a ligand-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself." [GOC:dph, GOC:tb]
synonym: "ligand-dependent nuclear receptor transcription co-activator activity" EXACT []
synonym: "ligand-dependent nuclear receptor transcription coactivator activity" EXACT []
is_a: GO:0003713 ! transcription coactivator activity

[Term]
id: GO:0030375
name: thyroid hormone receptor coactivator activity
namespace: molecular_function
def: "The function of a transcription cofactor that activates transcription in conjunction with a thyroid hormone-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself." [GOC:dph, GOC:tb]
synonym: "thyroid hormone receptor co-activator activity" EXACT []
is_a: GO:0010861 ! thyroid hormone receptor activator activity
is_a: GO:0030374 ! ligand-dependent nuclear receptor transcription coactivator activity

[Term]
id: GO:0030377
name: urokinase plasminogen activator receptor activity
namespace: molecular_function
def: "Combining with the urokinase plasminogen activator to initiate a change in cell activity." [GOC:mah, PMID:16456079]
synonym: "U-plasminogen activator receptor activity" EXACT [GOC:bf]
synonym: "uPAR" EXACT []
synonym: "urokinase plasminogen activator receptor" EXACT []
xref: Wikipedia:Urokinase_receptor
is_a: GO:0038023 ! signaling receptor activity
relationship: part_of GO:0038195 ! urokinase plasminogen activator signaling pathway

[Term]
id: GO:0030378
name: serine racemase activity
namespace: molecular_function
def: "Catalysis of the synthesis of free D-serine from L-serine." [GOC:kd]
xref: MetaCyc:5.1.1.18-RXN
is_a: GO:0047661 ! amino-acid racemase activity

[Term]
id: GO:0030379
name: neurotensin receptor activity, non-G-protein coupled
namespace: molecular_function
def: "Combining with neurotensin, a neuropeptide active in the central and peripheral nervous system in mammals, and transmitting the signal from one side of the membrane to the other by a mechanism independent of coupling to G proteins." [GOC:mah, GOC:signaling, PMID:9756851]
synonym: "neurotensin receptor activity, non G protein coupled" EXACT []
synonym: "non G protein coupled neurotensin receptor activity" EXACT []
synonym: "non-G-protein coupled neurotensin receptor activity" EXACT []
synonym: "non-G-protein-coupled neurotensin receptor activity" EXACT []
is_a: GO:0004888 ! transmembrane signaling receptor activity

[Term]
id: GO:0030380
name: interleukin-17E receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-17E receptor." [GOC:ai]
synonym: "IL-17E" NARROW []
synonym: "interleukin-17E receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0030381
name: chorion-containing eggshell pattern formation
namespace: biological_process
def: "The regionalization process that gives rise to the structural pattern of a chorion-containing eggshell such as those found in insects." [GOC:bf, GOC:mtg_sensu]
is_a: GO:0003002 ! regionalization
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
relationship: part_of GO:0007304 ! chorion-containing eggshell formation

[Term]
id: GO:0030382
name: sperm mitochondrion organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of sperm mitochondria; the process in which they take on their characteristic morphology; they are flattened, elongated, and arranged circumferentially into a tight helical coil around the tail-dense fibers of the mature sperm." [GOC:dph, GOC:jl, GOC:mah, PMID:8833144]
synonym: "sperm mitochondria organisation" EXACT [GOC:curators]
synonym: "sperm mitochondria organization and biogenesis" RELATED [GOC:mah]
synonym: "sperm mitochondrion organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0007005 ! mitochondrion organization

[Term]
id: GO:0030383
name: obsolete host-pathogen interaction
namespace: biological_process
def: "OBSOLETE. Any interaction between a pathogen and its host organism." [GOC:jl]
comment: This term was made obsolete because more appropriate terms were created.
synonym: "host-pathogen interaction" EXACT []
is_obsolete: true
consider: GO:0044403

[Term]
id: GO:0030385
name: ferredoxin:thioredoxin reductase activity
namespace: molecular_function
def: "Catalysis of the two-electron reduction of the disulfide of thioredoxins with electrons from ferredoxin involving a 4Fe-4S cluster and an adjacent active-site disulfide." [PMID:14769790]
is_a: GO:0016730 ! oxidoreductase activity, acting on iron-sulfur proteins as donors

[Term]
id: GO:0030386
name: ferredoxin:thioredoxin reductase complex
namespace: cellular_component
def: "A protein complex that possesses ferredoxin:thioredoxin reductase activity." [GOC:mah]
comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'ferredoxin:thioredoxin reductase activity ; GO:0030385'.
is_a: GO:0044434 ! chloroplast part
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:0030387
name: fructosamine-3-kinase activity
namespace: molecular_function
def: "Catalysis of the phosphorylation of fructosamine to form fructosamine-3-kinase." [PMID:11016445]
is_a: GO:0016301 ! kinase activity

[Term]
id: GO:0030388
name: fructose 1,6-bisphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fructose 1,6-bisphosphate, also known as FBP. The D enantiomer is a metabolic intermediate in glycolysis and gluconeogenesis." [ISBN:0198506732]
subset: gosubset_prok
synonym: "fructose 1,6-bisphosphate metabolism" EXACT []
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:0030389
name: fructosamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group." [GOC:jl, ISBN:0192801023]
subset: gosubset_prok
synonym: "fructosamine metabolism" EXACT []
is_a: GO:0006040 ! amino sugar metabolic process

[Term]
id: GO:0030391
name: fructosamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group." [GOC:jl, ISBN:0192801023]
subset: gosubset_prok
synonym: "fructosamine anabolism" EXACT []
synonym: "fructosamine biosynthesis" EXACT []
synonym: "fructosamine formation" EXACT []
synonym: "fructosamine synthesis" EXACT []
is_a: GO:0030389 ! fructosamine metabolic process
is_a: GO:0046349 ! amino sugar biosynthetic process

[Term]
id: GO:0030392
name: fructosamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group." [GOC:jl, ISBN:0192801023]
subset: gosubset_prok
synonym: "fructosamine breakdown" EXACT []
synonym: "fructosamine catabolism" EXACT []
synonym: "fructosamine degradation" EXACT []
is_a: GO:0030389 ! fructosamine metabolic process
is_a: GO:0046348 ! amino sugar catabolic process

[Term]
id: GO:0030393
name: fructoselysine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fructoselysine, a fructose molecule containing a lysine group in place of a hydroxyl group." [GOC:ai]
subset: gosubset_prok
synonym: "fructoselysine metabolism" EXACT []
is_a: GO:0006520 ! cellular amino acid metabolic process
is_a: GO:0030389 ! fructosamine metabolic process

[Term]
id: GO:0030394
name: fructoseglycine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fructoseglycine, a fructose molecule containing a glycine group in place of a hydroxyl group." [GOC:ai]
subset: gosubset_prok
synonym: "fructoseglycine metabolism" EXACT []
is_a: GO:0006520 ! cellular amino acid metabolic process
is_a: GO:0006575 ! cellular modified amino acid metabolic process
is_a: GO:0030389 ! fructosamine metabolic process

[Term]
id: GO:0030395
name: lactose binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with lactose, a disaccharide of glucose and galactose, the carbohydrate of milk." [GOC:jl, ISBN:01928006X]
is_a: GO:0048030 ! disaccharide binding

[Term]
id: GO:0030397
name: membrane disassembly
namespace: biological_process
def: "The controlled breakdown of any cell membrane in the context of a normal process such as autophagy." [GOC:mah]
synonym: "membrane breakdown" EXACT []
synonym: "membrane catabolism" EXACT []
synonym: "membrane degradation" EXACT []
is_a: GO:0022411 ! cellular component disassembly
is_a: GO:0044802 ! single-organism membrane organization

[Term]
id: GO:0030398
name: peroxisomal membrane disassembly
namespace: biological_process
def: "The controlled breakdown of the membranes of cargo-carrying vesicles formed during peroxisome degradation." [GOC:mah, PMID:11382760]
synonym: "peroxisomal membrane breakdown" EXACT []
synonym: "peroxisomal membrane catabolism" EXACT []
synonym: "peroxisomal membrane degradation" EXACT []
is_a: GO:0030397 ! membrane disassembly
is_a: GO:1903008 ! organelle disassembly
relationship: part_of GO:0030242 ! pexophagy

[Term]
id: GO:0030399
name: autophagosome membrane disassembly
namespace: biological_process
def: "The controlled breakdown of the membranes of autophagosomes." [GOC:autophagy, GOC:mah]
synonym: "autophagic membrane breakdown" EXACT []
synonym: "autophagic membrane catabolism" EXACT []
synonym: "autophagic membrane degradation" EXACT []
synonym: "autophagic vacuole membrane disassembly" EXACT [GOC:autophagy]
is_a: GO:0030397 ! membrane disassembly
is_a: GO:1902589 ! single-organism organelle organization
is_a: GO:1905037 ! autophagosome organization

[Term]
id: GO:0030400
name: obsolete protease substrate recruitment factor activity
namespace: molecular_function
def: "OBSOLETE. A recruiting factor or adaptor molecule associated with the proteasome that activates degradation of specific proteasomal substrates and links them to the degradation machinery; it is not involved in ubiquitination; does not possess proteolytic activity." [PMID:11500370]
comment: This term was made obsolete because it represents a gene product.
synonym: "protease substrate recruitment factor activity" EXACT []
is_obsolete: true
consider: GO:0030674

[Term]
id: GO:0030401
name: obsolete transcription antiterminator activity
namespace: molecular_function
def: "OBSOLETE. Functions to prevent the termination of RNA synthesis. Acts as a regulatory device, e.g. in phage lambda, enabling a terminator to be masked from RNA polymerase so that distal genes can be expressed." [ISBN:0198506732]
comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
subset: gosubset_prok
synonym: "transcription antiterminator activity" EXACT []
synonym: "transcriptional antiterminator activity" EXACT []
is_obsolete: true
consider: GO:0001072
consider: GO:0001073
consider: GO:0006353

[Term]
id: GO:0030402
name: obsolete matrilysin-2 activity
namespace: molecular_function
def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "matrilysin-2 activity" EXACT []
synonym: "matrix metalloproteinase 26" EXACT []
synonym: "MMP-26" EXACT []
xref: EC:3.4.24.-
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0030403
name: obsolete collagenase 4 activity
namespace: molecular_function
def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "collagenase 4 activity" EXACT []
synonym: "matrix metalloproteinase 18" EXACT []
synonym: "MMP-18" NARROW []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0030404
name: obsolete collagenase 3 activity
namespace: molecular_function
def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "collagenase 3 activity" EXACT []
synonym: "matrix metalloproteinase 13" EXACT []
synonym: "MMP-13" EXACT []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0030405
name: obsolete matrix metalloproteinase 19 activity
namespace: molecular_function
def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "matrix metalloproteinase 19 activity" EXACT []
synonym: "MMP-19" EXACT []
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0030406
name: obsolete matrix metalloproteinase 25 activity
namespace: molecular_function
def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "matrix metalloproteinase 25 activity" EXACT []
synonym: "MMP-25" EXACT []
synonym: "MT6-MMP" EXACT []
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0030407
name: formimidoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a formimino group from 5-formimidoyltetrahydrofolate to an acceptor molecule such as an amino acid." [EC:2.1.2.4, EC:2.1.2.5, GOC:mah]
subset: gosubset_prok
synonym: "formiminotransferase activity" EXACT []
xref: EC:2.1.2.-
is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity

[Term]
id: GO:0030408
name: glycine formimidoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-formimidoyltetrahydrofolate + glycine = (6S)-5,6,7,8-tetrahydrofolate + N-formimidoylglycine." [EC:2.1.2.4, RHEA:24291]
synonym: "5-formimidoyltetrahydrofolate:glycine N-formimidoyltransferase activity" EXACT [EC:2.1.2.4]
synonym: "FIG formiminotransferase activity" EXACT [EC:2.1.2.4]
synonym: "formiminoglycine formiminotransferase activity" EXACT [EC:2.1.2.4]
synonym: "glycine formiminotransferase activity" EXACT []
xref: EC:2.1.2.4
xref: KEGG:R02729
xref: MetaCyc:GLYCINE-FORMIMINOTRANSFERASE-RXN
xref: RHEA:24291
is_a: GO:0030407 ! formimidoyltransferase activity

[Term]
id: GO:0030409
name: glutamate formimidoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate." [EC:2.1.2.5]
subset: gosubset_prok
synonym: "5-formimidoyltetrahydrofolate:L-glutamate N-formimidoyltransferase activity" EXACT [EC:2.1.2.5]
synonym: "formiminoglutamic acid transferase activity" EXACT [EC:2.1.2.5]
synonym: "formiminoglutamic formiminotransferase activity" EXACT [EC:2.1.2.5]
synonym: "glutamate formiminotransferase activity" EXACT []
synonym: "glutamate formyltransferase activity" EXACT [EC:2.1.2.5]
xref: EC:2.1.2.5
xref: MetaCyc:GLUTAMATE-FORMIMINOTRANSFERASE-RXN
is_a: GO:0030407 ! formimidoyltransferase activity

[Term]
id: GO:0030410
name: nicotianamine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3 S-adenosyl-L-methionine(1+) = 3 S-methyl-5'-thioadenosine + 3 H(+) + nicotianamine." [EC:2.5.1.43, RHEA:16484]
subset: gosubset_prok
synonym: "S-adenosyl-L-methionine:S-adenosyl-L-methionine:S-adenosyl-L-methionine 3-amino-3-carboxypropyltransferase activity" EXACT [EC:2.5.1.43]
xref: EC:2.5.1.43
xref: KEGG:R00075
xref: MetaCyc:2.5.1.43-RXN
xref: RHEA:16484
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0030411
name: scytalone dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: scytalone = 1,3,8-trihydroxynaphthalene + H(2)O." [EC:4.2.1.94, RHEA:24399]
synonym: "scytalone 7,8-hydro-lyase (1,3,8-trihydroxynaphthalene-forming)" EXACT [EC:4.2.1.94]
synonym: "scytalone 7,8-hydro-lyase activity" EXACT [EC:4.2.1.94]
xref: EC:4.2.1.94
xref: KEGG:R02907
xref: MetaCyc:SCYTALONE-DEHYDRATASE-RXN
xref: RHEA:24399
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0030412
name: formimidoyltetrahydrofolate cyclodeaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-formimidoyltetrahydrofolate + 2 H(+) = 5,10-methenyltetrahydrofolate + NH(4)(+)." [EC:4.3.1.4, RHEA:22739]
subset: gosubset_prok
synonym: "5-formimidoyltetrahydrofolate ammonia-lyase (cyclizing)" EXACT [EC:4.3.1.4]
synonym: "5-formimidoyltetrahydrofolate ammonia-lyase (cyclizing; 5,10-methenyltetrahydrofolate-forming)" EXACT [EC:4.3.1.4]
synonym: "formiminotetrahydrofolate cyclodeaminase activity" EXACT [EC:4.3.1.4]
xref: EC:4.3.1.4
xref: KEGG:R02302
xref: MetaCyc:4.3.1.4-RXN
xref: Reactome:REACT_103744 "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate, Bos taurus"
xref: Reactome:REACT_105361 "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate, Danio rerio"
xref: Reactome:REACT_110330 "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate, Canis familiaris"
xref: Reactome:REACT_28157 "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate, Xenopus tropicalis"
xref: Reactome:REACT_31553 "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate, Sus scrofa"
xref: Reactome:REACT_485 "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate, Homo sapiens"
xref: Reactome:REACT_78662 "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate, Dictyostelium discoideum"
xref: Reactome:REACT_79630 "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate, Mus musculus"
xref: Reactome:REACT_80939 "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate, Gallus gallus"
xref: Reactome:REACT_94665 "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate, Arabidopsis thaliana"
xref: Reactome:REACT_95008 "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate, Taeniopygia guttata"
xref: Reactome:REACT_99986 "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate, Rattus norvegicus"
xref: RHEA:22739
is_a: GO:0016841 ! ammonia-lyase activity
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0030413
name: competence pheromone activity
namespace: molecular_function
def: "A small peptide excreted by a naturally transformable bacterium (e.g. Bacillus subtilis) that transmits a signal required for the establishment of competence." [GOC:mah, PMID:7698645]
subset: gosubset_prok
is_a: GO:0005186 ! pheromone activity

[Term]
id: GO:0030414
name: peptidase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]
subset: gosubset_prok
synonym: "protease inhibitor activity" NARROW [GOC:mah]
is_a: GO:0004857 ! enzyme inhibitor activity
is_a: GO:0061134 ! peptidase regulator activity
relationship: negatively_regulates GO:0008233 ! peptidase activity
relationship: part_of GO:0010466 ! negative regulation of peptidase activity

[Term]
id: GO:0030415
name: obsolete carboxypeptidase A inhibitor activity
namespace: molecular_function
def: "OBSOLETE. Stops, prevents or reduces the activity of the enzyme carboxypeptidase A." [GOC:ai]
comment: This term was made obsolete because it represents a regulator of an obsolete molecular function.
synonym: "carboxypeptidase A inhibitor activity" EXACT []
is_obsolete: true
replaced_by: GO:0030414

[Term]
id: GO:0030416
name: methylamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving methylamine (CH3NH2)." [ISBN:0721662544]
subset: gosubset_prok
synonym: "methylamine metabolism" EXACT []
synonym: "methylammonium metabolic process" EXACT []
synonym: "methylammonium metabolism" EXACT []
is_a: GO:0009308 ! amine metabolic process
is_a: GO:0097164 ! ammonium ion metabolic process
is_a: GO:1901160 ! primary amino compound metabolic process

[Term]
id: GO:0030417
name: nicotianamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nicotianamine, 2(S),3'2(S),3''(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid." [GOC:mah, PMID:10069850]
subset: gosubset_prok
synonym: "nicotianamine metabolism" EXACT []
is_a: GO:0006576 ! cellular biogenic amine metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:0072350 ! tricarboxylic acid metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process

[Term]
id: GO:0030418
name: nicotianamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nicotianamine, 2(S),3'2(S),3''(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid." [GOC:mah, PMID:10069850]
subset: gosubset_prok
synonym: "nicotianamine anabolism" EXACT []
synonym: "nicotianamine biosynthesis" EXACT []
synonym: "nicotianamine formation" EXACT []
synonym: "nicotianamine synthesis" EXACT []
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0030417 ! nicotianamine metabolic process
is_a: GO:0042401 ! cellular biogenic amine biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:0072351 ! tricarboxylic acid biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process

[Term]
id: GO:0030419
name: nicotianamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of nicotianamine, 2(S),3'2(S),3''(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid." [GOC:mah, PMID:10069850]
subset: gosubset_prok
synonym: "nicotianamine breakdown" EXACT []
synonym: "nicotianamine catabolism" EXACT []
synonym: "nicotianamine degradation" EXACT []
is_a: GO:0030417 ! nicotianamine metabolic process
is_a: GO:0042402 ! cellular biogenic amine catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:0072352 ! tricarboxylic acid catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process

[Term]
id: GO:0030420
name: establishment of competence for transformation
namespace: biological_process
def: "The process in which a naturally transformable bacterium acquires the ability to take up exogenous DNA. This term should be applied only to naturally transformable bacteria, and should not be used in the context of artificially induced bacterial transformation." [GOC:mah, ISBN:1555811027]
subset: gosubset_prok
is_a: GO:0031668 ! cellular response to extracellular stimulus
relationship: part_of GO:0009294 ! DNA mediated transformation

[Term]
id: GO:0030421
name: defecation
namespace: biological_process
def: "The expulsion of feces from the rectum." [GOC:mah]
xref: Wikipedia:Defecation
is_a: GO:0007588 ! excretion

[Term]
id: GO:0030422
name: production of siRNA involved in RNA interference
namespace: biological_process
def: "Cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of RNA interference." [GOC:mah, PMID:11524674]
synonym: "production of guide RNAs involved in RNA interference" EXACT [GOC:mah]
synonym: "RNA interference, production of guide RNAs" EXACT []
synonym: "RNA interference, production of siRNA" EXACT [GOC:mah]
is_a: GO:0070918 ! production of small RNA involved in gene silencing by RNA
relationship: part_of GO:0016246 ! RNA interference

[Term]
id: GO:0030423
name: targeting of mRNA for destruction involved in RNA interference
namespace: biological_process
def: "The process in which small interfering RNAs target cognate mRNA molecules for degradation." [PMID:11524674]
synonym: "RNA interference, targeting of mRNA for destruction" EXACT [GOC:mah]
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0016246 ! RNA interference

[Term]
id: GO:0030424
name: axon
namespace: cellular_component
def: "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]
xref: NIF_Subcellular:sao1770195789
xref: Wikipedia:Axon
is_a: GO:0043005 ! neuron projection

[Term]
id: GO:0030425
name: dendrite
namespace: cellular_component
def: "A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
xref: NIF_Subcellular:sao1211023249
xref: Wikipedia:Dendrite
is_a: GO:0043005 ! neuron projection
relationship: part_of GO:0036477 ! somatodendritic compartment

[Term]
id: GO:0030426
name: growth cone
namespace: cellular_component
def: "The migrating motile tip of a growing nerve cell axon or dendrite." [ISBN:0815316194]
xref: Wikipedia:Growth_cone
is_a: GO:0030427 ! site of polarized growth
is_a: GO:0044463 ! cell projection part
is_a: GO:0097458 ! neuron part
relationship: part_of GO:0043005 ! neuron projection

[Term]
id: GO:0030427
name: site of polarized growth
namespace: cellular_component
alt_id: GO:0000134
alt_id: GO:0030483
def: "Any part of a cell where non-isotropic growth takes place." [GOC:mah]
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_pir
subset: goslim_yeast
is_a: GO:0044464 ! cell part

[Term]
id: GO:0030428
name: cell septum
namespace: cellular_component
def: "A structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells." [GOC:clt, ISBN:0471940526]
subset: goslim_pir
subset: gosubset_prok
synonym: "cross wall" EXACT []
synonym: "septum" BROAD []
is_a: GO:0044464 ! cell part

[Term]
id: GO:0030429
name: kynureninase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-kynurenine + H2O = anthranilate + L-alanine." [EC:3.7.1.3]
subset: gosubset_prok
synonym: "kynurenine hydrolase activity" EXACT [EC:3.7.1.3]
synonym: "L-kynurenine hydrolase activity" EXACT [EC:3.7.1.3]
xref: EC:3.7.1.3
xref: MetaCyc:KYNURENINASE-RXN
xref: Reactome:REACT_101846 "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine, Taeniopygia guttata"
xref: Reactome:REACT_102197 "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine, Bos taurus"
xref: Reactome:REACT_104686 "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine, Dictyostelium discoideum"
xref: Reactome:REACT_109813 "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine, Caenorhabditis elegans"
xref: Reactome:REACT_114922 "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine, Xenopus tropicalis"
xref: Reactome:REACT_2234 "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine, Homo sapiens"
xref: Reactome:REACT_30212 "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine, Sus scrofa"
xref: Reactome:REACT_31685 "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine, Saccharomyces cerevisiae"
xref: Reactome:REACT_33339 "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine, Canis familiaris"
xref: Reactome:REACT_76974 "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine, Mus musculus"
xref: Reactome:REACT_77082 "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine, Danio rerio"
xref: Reactome:REACT_98796 "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine, Gallus gallus"
xref: Reactome:REACT_99752 "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine, Rattus norvegicus"
xref: RHEA:16816
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0030430
name: host cell cytoplasm
namespace: cellular_component
def: "The cytoplasm of a host cell." [GOC:mah]
subset: gosubset_prok
is_a: GO:0033646 ! host intracellular part

[Term]
id: GO:0030431
name: sleep
namespace: biological_process
def: "Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981]
subset: goslim_pir
synonym: "diapause" RELATED []
synonym: "dormancy" RELATED []
synonym: "lethargus" RELATED []
xref: Wikipedia:Sleep
is_a: GO:0044707 ! single-multicellular organism process

[Term]
id: GO:0030432
name: peristalsis
namespace: biological_process
def: "A wavelike sequence of involuntary muscular contraction and relaxation that passes along a tubelike structure, such as the intestine, impelling the contents onwards." [ISBN:0198506732]
xref: Wikipedia:Peristalsis
is_a: GO:0014821 ! phasic smooth muscle contraction

[Term]
id: GO:0030433
name: ER-associated ubiquitin-dependent protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation. This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858]
comment: See also the biological process terms 'ERAD pathway ; GO:0036503', 'unfolded protein response ; GO:0030968' and 'retrograde protein transport, ER to cytosol ; GO:0030970'.
synonym: "endoplasmic reticulum-associated protein catabolic process" EXACT []
synonym: "endoplasmic reticulum-associated protein catabolism" EXACT []
synonym: "ER-associated protein breakdown" EXACT []
synonym: "ER-associated protein catabolic process" EXACT [GOC:vw]
synonym: "ER-associated protein catabolism" EXACT []
synonym: "ER-associated protein degradation" EXACT []
synonym: "ERAD" BROAD []
synonym: "proteasomal protein catabolism of ER proteins" EXACT [GOC:bf]
is_a: GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process
relationship: part_of GO:0036503 ! ERAD pathway

[Term]
id: GO:0030435
name: sporulation resulting in formation of a cellular spore
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a cellular spore, a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction." [GOC:mah, GOC:pamgo_curators, ISBN:0072992913]
comment: Note that the synonym 'spore differentiation', like the term name and definition, refers to differentiation into a spore rather than any subsequent developmental changes that a spore may undergo.
subset: gosubset_prok
synonym: "cellular spore formation by sporulation" EXACT [GOC:dph, GOC:tb]
synonym: "spore biosynthesis" EXACT []
synonym: "spore differentiation" EXACT []
synonym: "spore formation" EXACT []
xref: Wikipedia:Sporogenesis
is_a: GO:0030154 ! cell differentiation
is_a: GO:0043934 ! sporulation
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis

[Term]
id: GO:0030436
name: asexual sporulation
namespace: biological_process
def: "The formation of spores derived from the products of mitosis. Examples of this process are found in Bacterial species." [GOC:mah, PMID:9529886]
subset: goslim_aspergillus
subset: gosubset_prok
synonym: "asexual spore formation" EXACT []
synonym: "mitotic spore formation" EXACT []
synonym: "mitotic sporulation" EXACT []
is_a: GO:0019954 ! asexual reproduction
is_a: GO:0043934 ! sporulation

[Term]
id: GO:0030437
name: ascospore formation
namespace: biological_process
alt_id: GO:0007151
def: "The process in which cells that are products of meiosis acquire the specialized features of ascospores. Ascospores are generally found in clusters of four or eight spores within a single mother cell, the ascus, and are characteristic of the ascomycete fungi (phylum Ascomycota)." [GOC:di, GOC:mah, GOC:mcc, PMID:16339736]
comment: Note that ascospores and asci are separate biological structures. The ascus is the structure that contain the ascospores, but the development of the ascus is a different process than the formation of the ascospores themselves; for instance, some mutations affect sporulation without affecting ascus development. For this reason, GO:0030437 ascospore formation and GO:0075317 ascus development are different terms and are not linked.
subset: goslim_pombe
synonym: "ascospore biosynthesis" EXACT []
synonym: "spore formation" BROAD []
synonym: "sporulation" BROAD []
is_a: GO:0022413 ! reproductive process in single-celled organism
is_a: GO:0043935 ! sexual sporulation resulting in formation of a cellular spore
is_a: GO:0048468 ! cell development

[Term]
id: GO:0030438
name: obsolete MAPKKK cascade during sporulation (sensu Fungi)
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mcc]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "MAPKKK cascade during sporulation (sensu Fungi)" EXACT []
is_obsolete: true

[Term]
id: GO:0030439
name: obsolete activation of MAPK during sporulation (sensu Fungi)
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mcc]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "activation of MAPK during sporulation (sensu Fungi)" EXACT []
is_obsolete: true

[Term]
id: GO:0030440
name: obsolete activation of MAPKK during sporulation (sensu Fungi)
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mcc]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "activation of MAPKK during sporulation (sensu Fungi)" EXACT []
is_obsolete: true

[Term]
id: GO:0030441
name: obsolete activation of MAPKKK during sporulation (sensu Fungi)
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mcc]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "activation of MAPKKK during sporulation (sensu Fungi)" EXACT []
is_obsolete: true

[Term]
id: GO:0030442
name: obsolete inactivation of MAPK during sporulation (sensu Fungi)
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mcc]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "inactivation of MAPK during sporulation (sensu Fungi)" EXACT []
is_obsolete: true

[Term]
id: GO:0030443
name: obsolete nuclear translocation of MAPK during sporulation (sensu Fungi)
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mcc]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "nuclear translocation of MAPK during sporulation (sensu Fungi)" EXACT []
is_obsolete: true

[Term]
id: GO:0030444
name: obsolete microtubule depolymerization during nuclear congression
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh]
comment: This term was made obsolete because the entire branch of the ontology was changed.
synonym: "microtubule depolymerization during nuclear congression" EXACT []
is_obsolete: true
replaced_by: GO:0007019

[Term]
id: GO:0030445
name: yeast-form cell wall
namespace: cellular_component
def: "The wall surrounding a cell of a dimorphic fungus growing in the single-cell budding yeast form, in contrast to the filamentous or hyphal form." [GOC:mah, GOC:mcc]
comment: See also the Fungal Anatomy Ontology term 'vegetative cell ; FAO:0000032'.
is_a: GO:0009277 ! fungal-type cell wall

[Term]
id: GO:0030446
name: hyphal cell wall
namespace: cellular_component
def: "The cell wall surrounding a fungal hypha." [GOC:mah]
comment: See also the Fungal Anatomy Ontology term 'hypha ; FAO:0001001'.
is_a: GO:0009277 ! fungal-type cell wall

[Term]
id: GO:0030447
name: filamentous growth
namespace: biological_process
def: "The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape." [GOC:mcc, PMID:11729141]
subset: goslim_aspergillus
subset: goslim_candida
is_a: GO:0040007 ! growth
is_a: GO:0044699 ! single-organism process

[Term]
id: GO:0030448
name: hyphal growth
namespace: biological_process
def: "Growth of fungi as threadlike, tubular structures that may contain multiple nuclei and may or may not be divided internally by septa, or cross-walls." [GOC:mcc, ISBN:0471522295]
subset: goslim_candida
is_a: GO:0030447 ! filamentous growth

[Term]
id: GO:0030449
name: regulation of complement activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of complement activation." [GOC:go_curators]
synonym: "regulation of complement cascade" EXACT [GOC:add]
is_a: GO:0002673 ! regulation of acute inflammatory response
is_a: GO:0002697 ! regulation of immune effector process
is_a: GO:0002920 ! regulation of humoral immune response
is_a: GO:0070613 ! regulation of protein processing
is_a: GO:2000257 ! regulation of protein activation cascade
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006956 ! complement activation
relationship: regulates GO:0006956 ! complement activation

[Term]
id: GO:0030450
name: regulation of complement activation, classical pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the classical pathway of complement activation." [GOC:go_curators]
synonym: "regulation of complement cascade, classical pathway" EXACT [GOC:add]
is_a: GO:0002923 ! regulation of humoral immune response mediated by circulating immunoglobulin
is_a: GO:0030449 ! regulation of complement activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006958 ! complement activation, classical pathway
relationship: regulates GO:0006958 ! complement activation, classical pathway

[Term]
id: GO:0030451
name: regulation of complement activation, alternative pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the alternative pathway of complement activation." [GOC:go_curators]
synonym: "regulation of complement cascade, alternative pathway" EXACT [GOC:add]
is_a: GO:0030449 ! regulation of complement activation
is_a: GO:0045088 ! regulation of innate immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006957 ! complement activation, alternative pathway
relationship: regulates GO:0006957 ! complement activation, alternative pathway

[Term]
id: GO:0030455
name: obsolete MAPKKK cascade (mating sensu Fungi)
namespace: biological_process
def: "OBSOLETE. MAPKKK cascade involved in transducing mating pheromone signal in a fungus." [GOC:mah]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "MAPKKK cascade (mating sensu Fungi)" EXACT []
is_obsolete: true
replaced_by: GO:0000750

[Term]
id: GO:0030456
name: obsolete activation of MAPK (mating sensu Fungi)
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "activation of MAPK (mating sensu Fungi)" EXACT []
is_obsolete: true
replaced_by: GO:0000750

[Term]
id: GO:0030457
name: obsolete activation of MAPKK (mating sensu Fungi)
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "activation of MAPKK (mating sensu Fungi)" EXACT []
is_obsolete: true
replaced_by: GO:0000750

[Term]
id: GO:0030458
name: obsolete activation of MAPKKK (mating sensu Fungi)
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "activation of MAPKKK (mating sensu Fungi)" EXACT []
is_obsolete: true
replaced_by: GO:0000750

[Term]
id: GO:0030459
name: obsolete inactivation of MAPK (mating sensu Fungi)
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "inactivation of MAPK (mating sensu Fungi)" EXACT []
is_obsolete: true
replaced_by: GO:0000750

[Term]
id: GO:0030460
name: obsolete nuclear translocation of MAPK (mating sensu Fungi)
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh]
comment: This term was made obsolete because it is a gene product specific term.
synonym: "nuclear translocation of MAPK (mating sensu Fungi)" EXACT []
is_obsolete: true
replaced_by: GO:0000750

[Term]
id: GO:0030463
name: obsolete cell aging (sensu Fungi)
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it does not describe a biological process that is distinct from 'cell aging'.
synonym: "cell aging (sensu Fungi)" EXACT []
is_obsolete: true
replaced_by: GO:0007569

[Term]
id: GO:0030464
name: obsolete aging dependent sterility (sensu Fungi)
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:sgd_curators]
comment: This term was made obsolete because it reflected a trait or phenotype.
synonym: "aging dependent sterility (sensu Fungi)" EXACT []
is_obsolete: true
consider: GO:0030466

[Term]
id: GO:0030465
name: obsolete autophagic death (sensu Fungi)
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because a more correct term has been created.
synonym: "autophagic death (sensu Fungi)" EXACT []
is_obsolete: true
consider: GO:0048102

[Term]
id: GO:0030466
name: chromatin silencing at silent mating-type cassette
namespace: biological_process
alt_id: GO:0006347
def: "Repression of transcription at silent mating-type loci by alteration of the structure of chromatin." [GOC:mcc]
synonym: "aging-dependent sterility" NARROW []
synonym: "chromatin silencing at HML and HMR" NARROW []
synonym: "heterochromatic silencing at silent mating-type cassette" EXACT []
synonym: "silent mating-type cassette chromatin silencing" EXACT [GOC:mah]
is_a: GO:0006342 ! chromatin silencing

[Term]
id: GO:0030470
name: obsolete spore germination (sensu Fungi)
namespace: biological_process
alt_id: GO:0007153
def: "OBSOLETE. Process of breakdown or opening of the spore-containing structure, modification of the spore wall, and resumption of growth of the spore. As in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751)." [GOC:mcc]
comment: This term was made obsolete because a sensu term was not needed.
synonym: "germination (sensu Saccharomyces)" NARROW []
synonym: "spore germination (sensu Fungi)" EXACT []
is_obsolete: true
replaced_by: GO:0009847

[Term]
id: GO:0030471
name: obsolete spindle pole body and microtubule cycle (sensu Fungi)
namespace: biological_process
alt_id: GO:0007102
def: "OBSOLETE. The dynamics of the spindle pole body and microtubule cytoskeleton during the cell cycle. Includes spindle pole body duplication and separation and formation and elongation of the mitotic spindle. As in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751)." [ISBN:0879693649]
comment: This term was made obsolete because it has been superseded by more accurate terms to represent the biological processes occurring, and it is not clear that this term represents a useful entity.
synonym: "spindle pole body and microtubule cycle (sensu Fungi)" EXACT []
synonym: "spindle pole body and microtubule cycle (sensu Saccharomyces)" NARROW []
is_obsolete: true
consider: GO:0007051
consider: GO:0051300

[Term]
id: GO:0030472
name: mitotic spindle organization in nucleus
namespace: biological_process
alt_id: GO:0000071
def: "A process resulting in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle in the nucleus. The process occurs during a mitotic cell cycle and takes place at the cellular level." [GOC:mah]
synonym: "mitotic spindle assembly" BROAD []
synonym: "mitotic spindle organisation in nucleus" EXACT []
synonym: "mitotic spindle organization and biogenesis in cell nucleus" EXACT []
synonym: "mitotic spindle organization and biogenesis in nucleus" EXACT []
synonym: "spindle organization and biogenesis in nucleus during mitosis" EXACT []
is_a: GO:0007052 ! mitotic spindle organization
intersection_of: GO:0007052 ! mitotic spindle organization
intersection_of: occurs_in GO:0005634 ! nucleus
relationship: occurs_in GO:0005634 ! nucleus

[Term]
id: GO:0030473
name: nuclear migration along microtubule
namespace: biological_process
alt_id: GO:0000065
def: "The directed movement of the nucleus along microtubules within the cell, mediated by motor proteins." [GOC:mah, GOC:sgd_curators]
synonym: "microtubule cytoskeleton-dependent nuclear positioning" EXACT []
synonym: "microtubule cytoskeleton-dependent nucleus positioning" EXACT []
synonym: "microtubule-dependent nuclear positioning" EXACT []
synonym: "microtubule-dependent nucleus positioning" EXACT []
synonym: "microtubule-mediated nuclear migration" EXACT []
synonym: "nuclear migration, microtubule-mediated" EXACT []
synonym: "nuclear movement, microtubule-mediated" BROAD []
synonym: "nucleus migration" BROAD []
synonym: "transport of nucleus by microtubules" EXACT []
synonym: "transport of nucleus, microtubule-mediated" EXACT []
is_a: GO:0007097 ! nuclear migration
is_a: GO:0072384 ! organelle transport along microtubule

[Term]
id: GO:0030474
name: spindle pole body duplication
namespace: biological_process
alt_id: GO:0007103
alt_id: GO:0031046
def: "Construction of a new spindle pole body." [GOC:clt]
synonym: "spindle pole body assembly" EXACT []
synonym: "spindle pole body biogenesis" EXACT []
synonym: "spindle pole body biosynthesis" EXACT []
synonym: "spindle pole body duplication associated with nuclear envelope" EXACT []
synonym: "spindle pole body duplication in cytoplasm" EXACT []
synonym: "spindle pole body formation" EXACT []
synonym: "spindle pole body replication" EXACT []
is_a: GO:0006461 ! protein complex assembly
is_a: GO:0051300 ! spindle pole body organization

[Term]
id: GO:0030476
name: ascospore wall assembly
namespace: biological_process
alt_id: GO:0007152
def: "The aggregation, arrangement and bonding together of a set of components to form an ascospore wall. During sporulation in Ascomycota, each ascospore nucleus becomes surrounded by a specialized spore wall, formed by deposition of spore wall components in the lumenal space between the outer and inner leaflets of the prospore membrane. An example of this process is found in Saccharomyces cerevisiae." [GOC:mcc, PMID:14702385]
synonym: "spore wall assembly" BROAD []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0042244 ! spore wall assembly
is_a: GO:0071940 ! fungal-type cell wall assembly
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0070591 ! ascospore wall biogenesis

[Term]
id: GO:0030478
name: actin cap
namespace: cellular_component
alt_id: GO:0000143
def: "Polarized accumulation of cytoskeletal proteins (including F-actin) and regulatory proteins in a cell. An example of this is the actin cap found in Saccharomyces cerevisiae." [GOC:mah, ISBN:10652251]
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044448 ! cell cortex part
relationship: part_of GO:0030864 ! cortical actin cytoskeleton

[Term]
id: GO:0030479
name: actin cortical patch
namespace: cellular_component
alt_id: GO:0005857
def: "An endocytic patch  that consists of an actin-containing structure found at the plasma membrane in cells; formed of networks of branched actin filaments that lie just beneath the plasma membrane and assemble, move, and disassemble rapidly. An example of this is the actin cortical patch found in Saccharomyces cerevisiae." [GOC:mah, GOC:vw, ISBN:0879693568, ISBN:0879693649, PMID:16959963]
synonym: "actin patch" EXACT []
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0061645 ! endocytic patch
relationship: part_of GO:0030864 ! cortical actin cytoskeleton

[Term]
id: GO:0030484
name: obsolete muscle fiber
namespace: cellular_component
def: "OBSOLETE. The contractile fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle." [GOC:mah, ISBN:0815316194]
comment: This term was made obsolete because a muscle fiber is a cell type rather than a cell component. To update annotations, consider the external ontology term 'muscle cell ; CL:0000187'.
synonym: "muscle fiber" EXACT []
synonym: "muscle fibre" EXACT []
is_obsolete: true
consider: GO:0043292

[Term]
id: GO:0030485
name: smooth muscle contractile fiber
namespace: cellular_component
def: "The contractile fiber of smooth muscle cells." [GOC:mah]
synonym: "smooth muscle fiber" BROAD []
synonym: "smooth muscle fibre" EXACT []
is_a: GO:0043292 ! contractile fiber
is_a: GO:0044449 ! contractile fiber part

[Term]
id: GO:0030486
name: smooth muscle dense body
namespace: cellular_component
def: "Electron-dense region associated with a smooth muscle contractile fiber." [GOC:mah, ISBN:0815316194]
is_a: GO:0044449 ! contractile fiber part
relationship: part_of GO:0030485 ! smooth muscle contractile fiber

[Term]
id: GO:0030487
name: inositol-4,5-bisphosphate 5-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate." [GOC:mah]
xref: EC:3.1.3.-
is_a: GO:0016312 ! inositol bisphosphate phosphatase activity

[Term]
id: GO:0030488
name: tRNA methylation
namespace: biological_process
def: "The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule." [GOC:mah]
subset: gosubset_prok
is_a: GO:0001510 ! RNA methylation
is_a: GO:0006400 ! tRNA modification

[Term]
id: GO:0030489
name: obsolete processing of 27S pre-rRNA
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:curators]
comment: This term was made obsolete because it was not defined and did not correspond to the production of a single specific mature rRNA product.
synonym: "processing of 27S pre-rRNA" EXACT []
is_obsolete: true

[Term]
id: GO:0030490
name: maturation of SSU-rRNA
namespace: biological_process
def: "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule." [GOC:curators]
synonym: "processing of 20S pre-rRNA" NARROW []
synonym: "SSU-rRNA maturation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0006364 ! rRNA processing
relationship: part_of GO:0042274 ! ribosomal small subunit biogenesis

[Term]
id: GO:0030491
name: heteroduplex formation
namespace: biological_process
def: "The formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules." [GOC:elh, PMID:10357855]
is_a: GO:0006259 ! DNA metabolic process

[Term]
id: GO:0030492
name: hemoglobin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin." [CHEBI:35143, GOC:jl]
synonym: "globin binding" BROAD []
synonym: "haemoglobin binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0030493
name: bacteriochlorophyll metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a bacteriochlorophyll, any of the chlorophylls of photosynthetic bacteria. They differ structurally from the chlorophylls of higher plants." [GOC:mah, ISBN:0198506732]
subset: gosubset_prok
synonym: "bacteriochlorophyll metabolism" EXACT []
is_a: GO:0015994 ! chlorophyll metabolic process

[Term]
id: GO:0030494
name: bacteriochlorophyll biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a bacteriochlorophyll, any of the chlorophylls of photosynthetic bacteria. They differ structurally from the chlorophylls of higher plants." [GOC:mah, ISBN:0198506732]
subset: gosubset_prok
synonym: "bacteriochlorophyll anabolism" EXACT []
synonym: "bacteriochlorophyll biosynthesis" EXACT []
synonym: "bacteriochlorophyll formation" EXACT []
synonym: "bacteriochlorophyll synthesis" EXACT []
is_a: GO:0015995 ! chlorophyll biosynthetic process
is_a: GO:0030493 ! bacteriochlorophyll metabolic process

[Term]
id: GO:0030495
name: bacteriochlorophyll catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of bacteriochlorophyll, any of the chlorophylls of photosynthetic bacteria. They differ structurally from the chlorophylls of higher plants." [GOC:go_curators]
subset: gosubset_prok
synonym: "bacteriochlorophyll breakdown" EXACT []
synonym: "bacteriochlorophyll catabolism" EXACT []
synonym: "bacteriochlorophyll degradation" EXACT []
is_a: GO:0015996 ! chlorophyll catabolic process
is_a: GO:0030493 ! bacteriochlorophyll metabolic process

[Term]
id: GO:0030496
name: midbody
namespace: cellular_component
def: "A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194]
subset: goslim_pir
xref: Wikipedia:Midbody_(cell_biology)
is_a: GO:0044464 ! cell part

[Term]
id: GO:0030497
name: fatty acid elongation
namespace: biological_process
def: "The elongation of a fatty acid chain by the sequential addition of two-carbon units." [ISBN:0716720094]
subset: gosubset_prok
is_a: GO:0006633 ! fatty acid biosynthetic process

[Term]
id: GO:0030500
name: regulation of bone mineralization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of bone mineralization." [GOC:go_curators]
is_a: GO:0030278 ! regulation of ossification
is_a: GO:0070167 ! regulation of biomineral tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030282 ! bone mineralization
relationship: regulates GO:0030282 ! bone mineralization

[Term]
id: GO:0030501
name: positive regulation of bone mineralization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of bone mineralization." [GOC:go_curators]
synonym: "activation of bone mineralization" NARROW []
synonym: "stimulation of bone mineralization" NARROW []
synonym: "up regulation of bone mineralization" EXACT []
synonym: "up-regulation of bone mineralization" EXACT []
synonym: "upregulation of bone mineralization" EXACT []
is_a: GO:0030500 ! regulation of bone mineralization
is_a: GO:0045778 ! positive regulation of ossification
is_a: GO:0070169 ! positive regulation of biomineral tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030282 ! bone mineralization
relationship: positively_regulates GO:0030282 ! bone mineralization

[Term]
id: GO:0030502
name: negative regulation of bone mineralization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of bone mineralization." [GOC:go_curators]
synonym: "down regulation of bone mineralization" EXACT []
synonym: "down-regulation of bone mineralization" EXACT []
synonym: "downregulation of bone mineralization" EXACT []
synonym: "inhibition of bone mineralization" NARROW []
is_a: GO:0030279 ! negative regulation of ossification
is_a: GO:0030500 ! regulation of bone mineralization
is_a: GO:0070168 ! negative regulation of biomineral tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030282 ! bone mineralization
relationship: negatively_regulates GO:0030282 ! bone mineralization

[Term]
id: GO:0030504
name: inorganic diphosphate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of inorganic diphosphate across a membrane." [PMID:11326272]
synonym: "inorganic pyrophosphate transporter activity" EXACT []
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity
relationship: part_of GO:0030505 ! inorganic diphosphate transport

[Term]
id: GO:0030505
name: inorganic diphosphate transport
namespace: biological_process
def: "The directed movement of inorganic diphosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "inorganic pyrophosphate transport" EXACT []
is_a: GO:0015698 ! inorganic anion transport

[Term]
id: GO:0030506
name: ankyrin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins." [GOC:mah, ISBN:0198506732]
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0030507
name: spectrin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers." [GOC:mah, ISBN:0198506732]
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0030508
name: obsolete thiol-disulfide exchange intermediate activity
namespace: molecular_function
def: "OBSOLETE. Functions as an exchange intermediate in thiol-disulfide exchange reactions." [GOC:kd, GOC:mah]
comment: This term was made obsolete because it represents a combination of gene product features and involvement in a biological process.
subset: gosubset_prok
synonym: "glutaredoxin" NARROW []
synonym: "thiol-disulfide exchange intermediate activity" EXACT []
synonym: "thiol-disulphide exchange intermediate activity" EXACT []
synonym: "thioredoxin" NARROW []
is_obsolete: true
consider: GO:0003756
consider: GO:0015036

[Term]
id: GO:0030509
name: BMP signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:0878932437, PR:000000034]
synonym: "BMP receptor signaling pathway" RELATED []
synonym: "BMP signalling pathway" EXACT []
synonym: "bone morphogenetic protein signaling pathway" EXACT []
synonym: "bone morphogenetic protein signalling pathway" EXACT []
xref: Reactome:REACT_105000 "Signaling by BMP, Mus musculus"
xref: Reactome:REACT_107332 "Signaling by BMP, Bos taurus"
xref: Reactome:REACT_12034 "Signaling by BMP, Homo sapiens"
xref: Reactome:REACT_28579 "Signaling by BMP, Sus scrofa"
xref: Reactome:REACT_31763 "Signaling by BMP, Taeniopygia guttata"
xref: Reactome:REACT_77157 "Signaling by BMP, Gallus gallus"
xref: Reactome:REACT_79322 "Signaling by BMP, Drosophila melanogaster"
xref: Reactome:REACT_80158 "Signaling by BMP, Rattus norvegicus"
xref: Reactome:REACT_81213 "Signaling by BMP, Xenopus tropicalis"
xref: Reactome:REACT_86022 "Signaling by BMP, Canis familiaris"
xref: Reactome:REACT_96139 "Signaling by BMP, Danio rerio"
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway
relationship: part_of GO:0071773 ! cellular response to BMP stimulus

[Term]
id: GO:0030510
name: regulation of BMP signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway." [GOC:mah]
synonym: "regulation of BMP receptor signaling pathway" RELATED []
synonym: "regulation of BMP signalling pathway" EXACT []
synonym: "regulation of bone morphogenetic protein signaling pathway" EXACT []
synonym: "regulation of bone morphogenetic protein signalling pathway" EXACT []
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
is_a: GO:0090287 ! regulation of cellular response to growth factor stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030509 ! BMP signaling pathway
relationship: regulates GO:0030509 ! BMP signaling pathway

[Term]
id: GO:0030511
name: positive regulation of transforming growth factor beta receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of TGF-beta receptor signaling pathway activity." [GOC:go_curators]
synonym: "activation of transforming growth factor beta receptor signaling pathway" NARROW []
synonym: "positive regulation of TGF-beta receptor signaling pathway" EXACT []
synonym: "positive regulation of TGFbeta receptor signaling pathway" EXACT []
synonym: "positive regulation of transforming growth factor beta receptor signalling pathway" EXACT []
synonym: "stimulation of transforming growth factor beta receptor signaling pathway" NARROW []
synonym: "up regulation of transforming growth factor beta receptor signaling pathway" EXACT []
synonym: "up-regulation of transforming growth factor beta receptor signaling pathway" EXACT []
synonym: "upregulation of transforming growth factor beta receptor signaling pathway" EXACT []
is_a: GO:0017015 ! regulation of transforming growth factor beta receptor signaling pathway
is_a: GO:0090100 ! positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
is_a: GO:1903846 ! positive regulation of cellular response to transforming growth factor beta stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007179 ! transforming growth factor beta receptor signaling pathway
relationship: positively_regulates GO:0007179 ! transforming growth factor beta receptor signaling pathway

[Term]
id: GO:0030512
name: negative regulation of transforming growth factor beta receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway." [GOC:mah]
synonym: "down regulation of transforming growth factor beta receptor signaling pathway" EXACT []
synonym: "down-regulation of transforming growth factor beta receptor signaling pathway" EXACT []
synonym: "downregulation of transforming growth factor beta receptor signaling pathway" EXACT []
synonym: "inhibition of transforming growth factor beta receptor signaling pathway" NARROW []
synonym: "negative regulation of TGF-beta receptor signaling pathway" EXACT []
synonym: "negative regulation of TGFbeta receptor signaling pathway" EXACT []
synonym: "negative regulation of transforming growth factor beta receptor signalling pathway" EXACT []
xref: Reactome:REACT_105250 "I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1), Danio rerio"
xref: Reactome:REACT_113798 "SKI complexes with the SMAD complex, suppressing TGF-beta signaling, Danio rerio"
xref: Reactome:REACT_6887 "SKI complexes with the SMAD complex, suppressing TGF-beta signaling, Homo sapiens"
xref: Reactome:REACT_6909 "I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1), Homo sapiens"
xref: Reactome:REACT_78193 "SKI complexes with the SMAD complex, suppressing TGF-beta signaling, Xenopus tropicalis"
xref: Reactome:REACT_79577 "SKI complexes with the SMAD complex, suppressing TGF-beta signaling, Bos taurus"
xref: Reactome:REACT_81179 "I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1), Mus musculus"
xref: Reactome:REACT_82804 "I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1), Canis familiaris"
xref: Reactome:REACT_86702 "SKI complexes with the SMAD complex, suppressing TGF-beta signaling, Rattus norvegicus"
xref: Reactome:REACT_87642 "SKI complexes with the SMAD complex, suppressing TGF-beta signaling, Drosophila melanogaster"
xref: Reactome:REACT_88145 "SKI complexes with the SMAD complex, suppressing TGF-beta signaling, Mus musculus"
xref: Reactome:REACT_90968 "I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1), Rattus norvegicus"
xref: Reactome:REACT_91943 "SKI complexes with the SMAD complex, suppressing TGF-beta signaling, Canis familiaris"
xref: Reactome:REACT_93061 "I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1), Xenopus tropicalis"
xref: Reactome:REACT_93800 "I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1), Bos taurus"
xref: Reactome:REACT_95269 "I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1), Sus scrofa"
is_a: GO:0017015 ! regulation of transforming growth factor beta receptor signaling pathway
is_a: GO:0090101 ! negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
is_a: GO:1903845 ! negative regulation of cellular response to transforming growth factor beta stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007179 ! transforming growth factor beta receptor signaling pathway
relationship: negatively_regulates GO:0007179 ! transforming growth factor beta receptor signaling pathway

[Term]
id: GO:0030513
name: positive regulation of BMP signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity." [GOC:go_curators]
synonym: "activation of BMP signaling pathway" NARROW []
synonym: "positive regulation of BMP receptor signaling pathway" RELATED []
synonym: "positive regulation of BMP signalling pathway" EXACT []
synonym: "positive regulation of bone morphogenetic protein signaling pathway" EXACT []
synonym: "positive regulation of bone morphogenetic protein signalling pathway" EXACT []
synonym: "stimulation of BMP signaling pathway" NARROW []
synonym: "up regulation of BMP signaling pathway" EXACT []
synonym: "up-regulation of BMP signaling pathway" EXACT []
synonym: "upregulation of BMP signaling pathway" EXACT []
is_a: GO:0030510 ! regulation of BMP signaling pathway
is_a: GO:0090100 ! positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030509 ! BMP signaling pathway
relationship: positively_regulates GO:0030509 ! BMP signaling pathway

[Term]
id: GO:0030514
name: negative regulation of BMP signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway." [GOC:go_curators]
synonym: "down regulation of BMP signaling pathway" EXACT []
synonym: "down-regulation of BMP signaling pathway" EXACT []
synonym: "downregulation of BMP signaling pathway" EXACT []
synonym: "inhibition of BMP signaling pathway" NARROW []
synonym: "negative regulation of BMP receptor signaling pathway" RELATED []
synonym: "negative regulation of BMP signalling pathway" EXACT []
synonym: "negative regulation of bone morphogenetic protein signaling pathway" EXACT []
synonym: "negative regulation of bone morphogenetic protein signalling pathway" EXACT []
is_a: GO:0030510 ! regulation of BMP signaling pathway
is_a: GO:0090101 ! negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
is_a: GO:0090288 ! negative regulation of cellular response to growth factor stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030509 ! BMP signaling pathway
relationship: negatively_regulates GO:0030509 ! BMP signaling pathway

[Term]
id: GO:0030515
name: snoRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with small nucleolar RNA." [GOC:mah]
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0030516
name: regulation of axon extension
namespace: biological_process
def: "Any process that modulates the rate, direction or extent of axon extension." [GOC:go_curators]
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:0050770 ! regulation of axonogenesis
is_a: GO:0061387 ! regulation of extent of cell growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048675 ! axon extension
relationship: regulates GO:0048675 ! axon extension

[Term]
id: GO:0030517
name: negative regulation of axon extension
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of axon outgrowth." [GOC:mah]
synonym: "down regulation of axon extension" EXACT []
synonym: "down-regulation of axon extension" EXACT []
synonym: "downregulation of axon extension" EXACT []
synonym: "inhibition of axon extension" NARROW []
is_a: GO:0030308 ! negative regulation of cell growth
is_a: GO:0030516 ! regulation of axon extension
is_a: GO:0048640 ! negative regulation of developmental growth
is_a: GO:0050771 ! negative regulation of axonogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048675 ! axon extension
relationship: negatively_regulates GO:0048675 ! axon extension

[Term]
id: GO:0030518
name: intracellular steroid hormone receptor signaling pathway
namespace: biological_process
def: "A series of molecular signals generated as a consequence of a intracellular steroid hormone receptor binding to one of its physiological ligands." [GOC:mah, GOC:signaling]
synonym: "steroid hormone receptor signaling pathway" BROAD [GOC:bf]
synonym: "steroid hormone receptor signalling pathway" BROAD [GOC:bf]
is_a: GO:0030522 ! intracellular receptor signaling pathway
is_a: GO:0043401 ! steroid hormone mediated signaling pathway

[Term]
id: GO:0030519
name: snoRNP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any part of a small nucleolar ribonucleoprotein particle." [GOC:mah]
is_a: GO:0043021 ! ribonucleoprotein complex binding

[Term]
id: GO:0030520
name: intracellular estrogen receptor signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of an intracellular estrogen receptor binding to one of its physiological ligands. The pathway begins with receptor-ligand binding, and ends with regulation of a downstream cellular process (e.g. transcription)." [GOC:mah, GOC:signaling]
synonym: "estrogen receptor signaling pathway" BROAD [GOC:bf]
synonym: "estrogen receptor signalling pathway" BROAD [GOC:bf]
is_a: GO:0030518 ! intracellular steroid hormone receptor signaling pathway

[Term]
id: GO:0030521
name: androgen receptor signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of an androgen binding to its receptor." [GOC:mah]
synonym: "androgen receptor signalling pathway" EXACT []
is_a: GO:0030518 ! intracellular steroid hormone receptor signaling pathway

[Term]
id: GO:0030522
name: intracellular receptor signaling pathway
namespace: biological_process
def: "Any series of molecular signals initiated by a ligand binding to an receptor located within a cell." [GOC:bf, GOC:mah]
synonym: "intracellular receptor mediated signaling pathway" EXACT []
synonym: "intracellular receptor-mediated signaling pathway" EXACT []
synonym: "intracellular receptor-mediated signalling pathway" EXACT []
is_a: GO:0007165 ! signal transduction

[Term]
id: GO:0030523
name: dihydrolipoamide S-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + dihydrolipoamide = CoA + S-acyldihydrolipoamide." [EC:2.3.1.12, GOC:mah]
subset: gosubset_prok
xref: EC:2.3.1.-
is_a: GO:0016417 ! S-acyltransferase activity

[Term]
id: GO:0030526
name: granulocyte macrophage colony-stimulating factor receptor complex
namespace: cellular_component
def: "The heterodimeric receptor for granulocyte macrophage colony-stimulating factor." [GOC:mah]
synonym: "GM-CSF receptor complex" EXACT [GOC:vk]
synonym: "granulocyte macrophage colony stimulating factor receptor complex" EXACT []
is_a: GO:0098802 ! plasma membrane receptor complex
relationship: part_of GO:0005887 ! integral component of plasma membrane

[Term]
id: GO:0030527
name: structural constituent of chromatin
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0030528
name: obsolete transcription regulator activity
namespace: molecular_function
def: "OBSOLETE. Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor." [GOC:mah]
comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "transcription regulator activity" EXACT []
synonym: "transcriptional regulator activity" EXACT []
is_obsolete: true
consider: GO:0000988
consider: GO:0001071
consider: GO:0006351

[Term]
id: GO:0030529
name: intracellular ribonucleoprotein complex
namespace: cellular_component
def: "An intracellular macromolecular complex containing both protein and RNA molecules." [GOC:krc, GOC:vesicles]
subset: goslim_pir
subset: gosubset_prok
synonym: "protein-RNA complex" BROAD []
synonym: "ribonucleoprotein" BROAD []
synonym: "ribonucleoprotein complex" BROAD []
synonym: "RNA-protein complex" BROAD []
synonym: "RNP" BROAD []
xref: Wikipedia:Ribonucleoprotein
is_a: GO:0044424 ! intracellular part
is_a: GO:1990904 ! ribonucleoprotein complex

[Term]
id: GO:0030530
name: obsolete heterogeneous nuclear ribonucleoprotein complex
namespace: cellular_component
def: "OBSOLETE. Particulate complex of heterogeneous nuclear RNA (hnRNA; a heterogeneous mixture of RNA molecules of high Mr with a rapid turnover rate that occurs in cell nuclei during protein synthesis; it is the form of RNA synthesized in eukaryotes by RNA polymerase II, that which is translated into protein) with protein, which is cell-specific and heterogeneous. The protein component may play a role in the processing of the hnRNA to mRNA." [ISBN:0198506732]
comment: This term was made because heterogeneous nuclear ribonucleoprotein is an experimental construct and does not correspond cleanly to a functional cellular entity.
synonym: "heterogeneous nuclear ribonucleoprotein" EXACT []
synonym: "heterogeneous nuclear ribonucleoprotein complex" EXACT []
synonym: "hnRNP" EXACT []
xref: Wikipedia:Heterogeneous_ribonucleoprotein_particle
is_obsolete: true
consider: GO:0005681
consider: GO:0030529

[Term]
id: GO:0030531
name: obsolete small cytoplasmic ribonucleoprotein complex
namespace: cellular_component
def: "OBSOLETE. A complex composed of RNA of the small cytoplasmic RNA (scRNA) class and protein, found in the cytoplasm." [GOC:krc, GOC:mah]
comment: This term was made obsolete because we are unsure what it is supposed to represent, it has no annotations and the only references to the phrase in the literature are old.
synonym: "scRNP" EXACT []
synonym: "small cytoplasmic ribonucleoprotein" EXACT []
synonym: "small cytoplasmic ribonucleoprotein complex" EXACT []
is_obsolete: true
replaced_by: GO:0030529

[Term]
id: GO:0030532
name: small nuclear ribonucleoprotein complex
namespace: cellular_component
def: "A complex composed of RNA of the small nuclear RNA (snRNA) class and protein, found in the nucleus of a eukaryotic cell. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP or U4/U6 snRNP. Many, but not all, of these complexes are involved in splicing of nuclear mRNAs." [GOC:krc, GOC:mah, ISBN:0879695897]
subset: goslim_pir
synonym: "small nuclear ribonucleoprotein" EXACT []
synonym: "snRNP" EXACT []
xref: Wikipedia:SnRNP
is_a: GO:0030529 ! intracellular ribonucleoprotein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0030533
name: triplet codon-amino acid adaptor activity
namespace: molecular_function
def: "The codon binding activity of a tRNA that positions an activated amino acid, mediating its insertion at the correct point in the sequence of a nascent polypeptide chain during protein synthesis." [GOC:hjd, GOC:mtg_MIT_16mar07, ISBN:0198506732]
comment: Note that this term can be used in place of the obsolete term 'transfer RNA ; GO:0005563'.
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_yeast
synonym: "transfer RNA" RELATED []
synonym: "tRNA" RELATED []
is_a: GO:0000499 ! base pairing with mRNA
is_a: GO:0060090 ! binding, bridging
relationship: part_of GO:0006412 ! translation

[Term]
id: GO:0030534
name: adult behavior
namespace: biological_process
def: "Behavior in a fully developed and mature organism." [GOC:mah, ISBN:0877797099]
comment: See also the biological process term 'behavior ; GO:0007610'.
synonym: "adult behavioral response to stimulus" EXACT []
synonym: "adult behaviour" EXACT []
synonym: "adult behavioural response to stimulus" EXACT []
is_a: GO:0044707 ! single-multicellular organism process
is_a: GO:0044708 ! single-organism behavior

[Term]
id: GO:0030535
name: obsolete adult feeding behavior (sensu Insecta)
namespace: biological_process
def: "OBSOLETE. Feeding behavior in a fully developed and mature organism, as described in insects." [GOC:go_curators, GOC:jid]
comment: This term was made obsolete because there is no clear difference between the sensu Insecta term and the generic term.
synonym: "adult feeding behavior (sensu Insecta)" EXACT []
is_obsolete: true
replaced_by: GO:0008343

[Term]
id: GO:0030536
name: larval feeding behavior
namespace: biological_process
def: "Feeding behavior in a larval (immature) organism." [GOC:mah]
comment: See also the biological process term 'feeding behavior ; GO:0007631'.
synonym: "larval feeding behaviour" EXACT []
is_a: GO:0007631 ! feeding behavior
is_a: GO:0030537 ! larval behavior

[Term]
id: GO:0030537
name: larval behavior
namespace: biological_process
alt_id: GO:0017037
def: "Behavior in a larval form of an organism, an immature organism that must undergo metamorphosis to assume adult characteristics." [GOC:mah, ISBN:0877797099]
comment: See also the biological process term 'behavior ; GO:0007610'.
synonym: "larval behaviour" EXACT []
is_a: GO:0044707 ! single-multicellular organism process
is_a: GO:0044708 ! single-organism behavior

[Term]
id: GO:0030538
name: embryonic genitalia morphogenesis
namespace: biological_process
def: "The process, occurring in the embryo, by which the anatomical structures of the genitalia are generated and organized." [GOC:bf]
synonym: "embryonic genital morphogenesis" RELATED []
is_a: GO:0035112 ! genitalia morphogenesis
is_a: GO:0048562 ! embryonic organ morphogenesis

[Term]
id: GO:0030539
name: male genitalia development
namespace: biological_process
def: "The process whose specific outcome is the progression of the male genitalia over time, from its formation to the mature structure." [GOC:ems, ISBN:0140512888]
synonym: "male genital development" EXACT []
is_a: GO:0048806 ! genitalia development
is_a: GO:0061458 ! reproductive system development
relationship: part_of GO:0046661 ! male sex differentiation

[Term]
id: GO:0030540
name: female genitalia development
namespace: biological_process
def: "The process whose specific outcome is the progression of the female genitalia over time, from formation to the mature structure." [GOC:mah]
synonym: "female genital development" EXACT []
is_a: GO:0048806 ! genitalia development
relationship: part_of GO:0046660 ! female sex differentiation

[Term]
id: GO:0030541
name: plasmid partitioning
namespace: biological_process
alt_id: GO:0030542
def: "Any process in which plasmids are segregated or distributed into daughter cells upon cell division." [GOC:mah]
subset: gosubset_prok
is_a: GO:0006276 ! plasmid maintenance

[Term]
id: GO:0030543
name: 2-micrometer plasmid partitioning
namespace: biological_process
def: "The process in which copies of the 2-micrometer plasmid, found in fungi such as Saccharomyces, are distributed to daughter cells upon cell division." [GOC:mah]
is_a: GO:0030541 ! plasmid partitioning

[Term]
id: GO:0030544
name: Hsp70 protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with Hsp70 proteins, any of a group of heat shock proteins around 70kDa in size." [ISBN:0198506732]
is_a: GO:0031072 ! heat shock protein binding

[Term]
id: GO:0030545
name: receptor regulator activity
namespace: molecular_function
def: "The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is changed." [GOC:ceb]
is_a: GO:0098772 ! molecular function regulator
intersection_of: GO:0003674 ! molecular_function
intersection_of: regulates GO:0004872 ! receptor activity
relationship: part_of GO:0010469 ! regulation of receptor activity
relationship: regulates GO:0004872 ! receptor activity

[Term]
id: GO:0030546
name: receptor activator activity
namespace: molecular_function
def: "The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is increased." [GOC:ceb]
is_a: GO:0030545 ! receptor regulator activity
relationship: part_of GO:2000273 ! positive regulation of receptor activity
relationship: positively_regulates GO:0004872 ! receptor activity

[Term]
id: GO:0030547
name: receptor inhibitor activity
namespace: molecular_function
def: "The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is decreased." [GOC:ceb]
is_a: GO:0030545 ! receptor regulator activity
relationship: negatively_regulates GO:0004872 ! receptor activity
relationship: part_of GO:2000272 ! negative regulation of receptor activity

[Term]
id: GO:0030548
name: acetylcholine receptor regulator activity
namespace: molecular_function
def: "Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is changed." [GOC:mah]
is_a: GO:0099602 ! neurotransmitter receptor regulator activity
relationship: regulates GO:0015464 ! acetylcholine receptor activity

[Term]
id: GO:0030549
name: acetylcholine receptor activator activity
namespace: molecular_function
def: "Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is increased." [GOC:mah]
is_a: GO:0030546 ! receptor activator activity
is_a: GO:0030548 ! acetylcholine receptor regulator activity
relationship: positively_regulates GO:0015464 ! acetylcholine receptor activity

[Term]
id: GO:0030550
name: acetylcholine receptor inhibitor activity
namespace: molecular_function
def: "Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is decreased." [GOC:mah]
is_a: GO:0030547 ! receptor inhibitor activity
is_a: GO:0030548 ! acetylcholine receptor regulator activity
relationship: negatively_regulates GO:0015464 ! acetylcholine receptor activity

[Term]
id: GO:0030551
name: cyclic nucleotide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:ai]
subset: gosubset_prok
is_a: GO:0000166 ! nucleotide binding

[Term]
id: GO:0030552
name: cAMP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate)." [GOC:ai]
subset: gosubset_prok
synonym: "3',5' cAMP binding" EXACT []
synonym: "3',5'-cAMP binding" EXACT []
synonym: "adenosine 3',5'-cyclophosphate binding" EXACT []
synonym: "cyclic AMP binding" EXACT []
is_a: GO:0030551 ! cyclic nucleotide binding
is_a: GO:0032559 ! adenyl ribonucleotide binding
is_a: GO:0043168 ! anion binding

[Term]
id: GO:0030553
name: cGMP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate)." [GOC:ai]
synonym: "3',5' cGMP binding" EXACT []
synonym: "3',5'-cGMP binding" EXACT []
synonym: "cyclic GMP binding" EXACT []
is_a: GO:0030551 ! cyclic nucleotide binding
is_a: GO:0032561 ! guanyl ribonucleotide binding
is_a: GO:0043168 ! anion binding

[Term]
id: GO:0030554
name: adenyl nucleotide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with adenyl nucleotides, any compound consisting of adenosine esterified with (ortho)phosphate." [ISBN:0198506732]
subset: goslim_chembl
subset: gosubset_prok
is_a: GO:0017076 ! purine nucleotide binding

[Term]
id: GO:0030555
name: RNA modification guide activity
namespace: molecular_function
def: "Specifies the site of a posttranscriptional modification in an RNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565]
comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins.
subset: goslim_generic
subset: goslim_yeast
is_a: GO:0000498 ! base pairing with RNA

[Term]
id: GO:0030556
name: rRNA modification guide activity
namespace: molecular_function
def: "Specifies the site of a posttranscriptional modification in an rRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565]
comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins.
is_a: GO:0000944 ! base pairing with rRNA
is_a: GO:0030555 ! RNA modification guide activity

[Term]
id: GO:0030557
name: tRNA modification guide activity
namespace: molecular_function
def: "Specifies the site of a posttranscriptional modification in a tRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565]
comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins.
is_a: GO:0000946 ! base pairing with tRNA
is_a: GO:0030555 ! RNA modification guide activity

[Term]
id: GO:0030558
name: RNA pseudouridylation guide activity
namespace: molecular_function
def: "Specifies the site of pseudouridylation in an RNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565]
comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins.
is_a: GO:0030555 ! RNA modification guide activity

[Term]
id: GO:0030559
name: rRNA pseudouridylation guide activity
namespace: molecular_function
def: "Specifies the site of pseudouridylation in an rRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565]
comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins.
is_a: GO:0030556 ! rRNA modification guide activity
is_a: GO:0030558 ! RNA pseudouridylation guide activity

[Term]
id: GO:0030560
name: tRNA pseudouridylation guide activity
namespace: molecular_function
def: "Specifies the site of pseudouridylation in a tRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565]
comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins.
is_a: GO:0030557 ! tRNA modification guide activity
is_a: GO:0030558 ! RNA pseudouridylation guide activity

[Term]
id: GO:0030561
name: RNA 2'-O-ribose methylation guide activity
namespace: molecular_function
def: "Specifies the site of 2'-O-ribose methylation in an RNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565]
comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins.
is_a: GO:0030555 ! RNA modification guide activity

[Term]
id: GO:0030562
name: rRNA 2'-O-ribose methylation guide activity
namespace: molecular_function
def: "Specifies the site of 2'-O-ribose methylation in an rRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565]
comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins.
is_a: GO:0030556 ! rRNA modification guide activity
is_a: GO:0030561 ! RNA 2'-O-ribose methylation guide activity

[Term]
id: GO:0030563
name: snRNA 2'-O-ribose methylation guide activity
namespace: molecular_function
def: "Activity that provides specificity to a methylase by using base complementarity to guide site-specific 2'-O-ribose methylations to a small nuclear RNA molecule." [PMID:11733745]
comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. Note that this term may be useful for annotating snoRNAs.
is_a: GO:0030561 ! RNA 2'-O-ribose methylation guide activity
is_a: GO:0030566 ! snRNA modification guide activity

[Term]
id: GO:0030564
name: tRNA 2'-O-ribose methylation guide activity
namespace: molecular_function
def: "Specifies the site of 2'-O-ribose methylation in a tRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565]
comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins.
is_a: GO:0030557 ! tRNA modification guide activity
is_a: GO:0030561 ! RNA 2'-O-ribose methylation guide activity

[Term]
id: GO:0030565
name: snRNA pseudouridylation guide activity
namespace: molecular_function
def: "Activity that provides specificity to a pseudouridine synthetase by using base complementarity to guide site-specific pseudouridylations to a small nuclear RNA molecule." [PMID:11733745]
comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. Note that this term may be useful for annotating snoRNAs.
is_a: GO:0030558 ! RNA pseudouridylation guide activity
is_a: GO:0030566 ! snRNA modification guide activity

[Term]
id: GO:0030566
name: snRNA modification guide activity
namespace: molecular_function
def: "Specifies the site of a posttranscriptional modification in an snRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565]
comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins.
is_a: GO:0000945 ! base pairing with snRNA
is_a: GO:0030555 ! RNA modification guide activity

[Term]
id: GO:0030567
name: obsolete thrombin activator activity
namespace: molecular_function
def: "OBSOLETE. Increases the rate of proteolysis catalyzed by thrombin." [GOC:mah]
comment: This term was made obsolete because it represents a regulator of an obsolete molecular function.
subset: gosubset_prok
synonym: "prothrombin activator activity" RELATED [GOC:dph, GOC:tb]
synonym: "thrombin activator activity" EXACT []
is_obsolete: true
replaced_by: GO:0016504

[Term]
id: GO:0030568
name: obsolete plasmin inhibitor activity
namespace: molecular_function
def: "OBSOLETE. Stops, prevents or reduces the activity of the serine endopeptidase plasmin." [GOC:mah]
comment: This term was made obsolete because it represents a regulator of an obsolete molecular function.
synonym: "plasmin inhibitor activity" EXACT []
is_obsolete: true
replaced_by: GO:0004867

[Term]
id: GO:0030569
name: obsolete chymotrypsin inhibitor activity
namespace: molecular_function
def: "OBSOLETE. Stops, prevents or reduces the activity of the serine endopeptidase chymotrypsin." [GOC:mah]
comment: This term was made obsolete because it represents a regulator of an obsolete molecular function term.
synonym: "chymotrypsin inhibitor activity" EXACT []
is_obsolete: true
replaced_by: GO:0004867

[Term]
id: GO:0030570
name: pectate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: a pectate = a pectate + a pectate oligosaccharide with 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate end. This reaction is the eliminative cleavage of pectate to give oligosaccharides with 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non-reducing ends." [EC:4.2.2.2]
subset: gosubset_prok
synonym: "(1->4)-alpha-D-galacturonan lyase activity" EXACT [EC:4.2.2.2]
synonym: "alpha-1,4-D-endopolygalacturonic acid lyase activity" EXACT [EC:4.2.2.2]
synonym: "endo-alpha-1,4-polygalacturonic acid lyase activity" EXACT [EC:4.2.2.2]
synonym: "endogalacturonate transeliminase activity" EXACT [EC:4.2.2.2]
synonym: "endopectin methyltranseliminase activity" EXACT [EC:4.2.2.2]
synonym: "pectate transeliminase activity" EXACT [EC:4.2.2.2]
synonym: "pectic acid lyase activity" EXACT [EC:4.2.2.2]
synonym: "pectic acid transeliminase activity" EXACT [EC:4.2.2.2]
synonym: "pectic lyase activity" BROAD [EC:4.2.2.2]
synonym: "pectin trans-eliminase activity" BROAD [EC:4.2.2.2]
synonym: "PGA lyase activity" EXACT [EC:4.2.2.2]
synonym: "polygalacturonate lyase activity" EXACT [EC:4.2.2.2]
synonym: "polygalacturonic acid lyase activity" EXACT [EC:4.2.2.2]
synonym: "polygalacturonic acid trans-eliminase activity" EXACT [EC:4.2.2.2]
synonym: "polygalacturonic transeliminase activity" EXACT [EC:4.2.2.2]
synonym: "PPase-N activity" EXACT [EC:4.2.2.2]
xref: EC:4.2.2.2
xref: MetaCyc:4.2.2.2-RXN
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0030572
name: phosphatidyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction involving the transfer of a phosphatidate (otherwise known as diacylglycerol 3-phosphosphate) group." [GOC:mb]
subset: gosubset_prok
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0030573
name: bile acid catabolic process
namespace: biological_process
alt_id: GO:0019613
def: "The chemical reactions and pathways resulting in the breakdown of bile acids, any of a group of steroid carboxylic acids occurring in bile." [GOC:go_curators]
synonym: "bile acid 7alpha-dehydroxylation pathway" NARROW []
synonym: "bile acid breakdown" EXACT []
synonym: "bile acid catabolism" EXACT []
synonym: "bile acid degradation" EXACT []
synonym: "cholate catabolic process" NARROW []
xref: MetaCyc:7ALPHADEHYDROX-PWY
is_a: GO:0006706 ! steroid catabolic process
is_a: GO:0008206 ! bile acid metabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:1901616 ! organic hydroxy compound catabolic process

[Term]
id: GO:0030574
name: collagen catabolic process
namespace: biological_process
def: "The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells." [GOC:mah, ISBN:0815316194]
synonym: "collagen breakdown" EXACT []
synonym: "collagen catabolism" EXACT []
synonym: "collagen degradation" EXACT []
is_a: GO:0032963 ! collagen metabolic process
is_a: GO:0044243 ! multicellular organism catabolic process
is_a: GO:0044712 ! single-organism catabolic process

[Term]
id: GO:0030575
name: nuclear body organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of any of the extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:dph, GOC:jl, GOC:mah]
synonym: "nuclear body organisation" EXACT [GOC:curators]
synonym: "nuclear body organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006997 ! nucleus organization

[Term]
id: GO:0030576
name: Cajal body organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of Cajal bodies, nuclear bodies that appear ultrastructurally as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter and are enriched in ribonucleoproteins, and certain general RNA polymerase II transcription factors." [GOC:mah, PMID:11031238]
comment: See also the cellular component term 'Cajal body ; GO:0015030'.
synonym: "Cajal body organisation" EXACT [GOC:curators]
synonym: "Cajal body organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0030575 ! nuclear body organization

[Term]
id: GO:0030577
name: Lands organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of Lands, a class of nuclear body that react against SP140 auto-antibodies." [GOC:mah, PMID:10921892, PMID:8695863]
comment: See also the cellular component term 'Lands ; GO:0016606'.
synonym: "Lands organisation" EXACT [GOC:curators]
synonym: "Lands organization and biogenesis" RELATED [GOC:mah]
synonym: "LYSP100-associated nuclear domain organization" EXACT [GOC:mah]
is_a: GO:0030575 ! nuclear body organization

[Term]
id: GO:0030578
name: PML body organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of PML bodies, a class of nuclear body; they react against SP100 auto-antibodies (PML = promyelocytic leukemia)." [GOC:mah, PMID:10806078]
comment: See also the cellular component term 'PML body ; GO:0016605'.
synonym: "PML body organisation" EXACT [GOC:curators]
synonym: "PML body organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0030575 ! nuclear body organization

[Term]
id: GO:0030579
name: ubiquitin-dependent SMAD protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of SMAD signaling proteins by ubiquitination and targeting to the proteasome." [GOC:go_curators]
synonym: "ubiquitin-dependent SMAD protein breakdown" EXACT []
synonym: "ubiquitin-dependent SMAD protein catabolism" EXACT []
synonym: "ubiquitin-dependent SMAD protein degradation" EXACT []
is_a: GO:0006511 ! ubiquitin-dependent protein catabolic process
relationship: part_of GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway

[Term]
id: GO:0030580
name: quinone cofactor methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosylmethionine during the synthesis of quinone cofactors such as ubiquinone (coenzyme Q), menaquinone (vitamin K2), plastoquinone and phylloquinone (vitamin K1)." [GOC:mb]
subset: gosubset_prok
is_a: GO:0008169 ! C-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030581
name: symbiont intracellular protein transport in host
namespace: biological_process
def: "The directed movement of a symbiont's proteins within a cell of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mb]
synonym: "host cell protein transport" EXACT []
synonym: "intracellular protein transport in host" EXACT []
is_a: GO:0051701 ! interaction with host
is_a: GO:0051708 ! intracellular protein transport in other organism involved in symbiotic interaction
intersection_of: GO:0015031 ! protein transport
intersection_of: occurs_in GO:0043657 ! host cell
relationship: occurs_in GO:0043657 ! host cell

[Term]
id: GO:0030582
name: fruiting body development
namespace: biological_process
def: "The process whose specific outcome is the progression of the fruiting body over time, from its formation to the mature structure. A fruiting body is a multicellular structure that contains spores." [GOC:mah, GOC:mtg_sensu]
comment: This term describes the development of a fruiting body that is a spore-bearing organ.  It is not intended to describe the development of myxococcal fruiting bodies.
synonym: "fruiting body formation" EXACT []
is_a: GO:0075259 ! spore-bearing organ development

[Term]
id: GO:0030583
name: myxococcal fruiting body development
namespace: biological_process
alt_id: GO:0055084
def: "The process whose specific outcome is the progression of the myxococcal fruiting body over time, from its formation to the mature structure. The process begins when myxococci respond to a lack of nutrients in the environment and ends when the myxococcal fruiting body is a mature structure." [GOC:mtg_sensu, ISBN:0815316194, PMID:11121786]
comment: For example, as seen in myxobacterium.  It is not intended to describe fruiting body development as is Dictyostelium.
subset: gosubset_prok
synonym: "fruiting body development in cellular response to starvation" BROAD []
synonym: "fruiting body development in response to starvation" BROAD []
is_a: GO:0042594 ! response to starvation
is_a: GO:0044764 ! multi-organism cellular process

[Term]
id: GO:0030584
name: sporocarp development
namespace: biological_process
def: "The process whose specific outcome is the progression of a sporocarp over time, from its formation to the mature structure. The sporocarp is a spore bearing fruiting body organ. An example of this process is found in the Fungal species Coprinopsis cinerea." [GOC:mah, GOC:mtg_sensu]
synonym: "fruiting body development" BROAD []
is_a: GO:0030582 ! fruiting body development

[Term]
id: GO:0030585
name: phosphoenolpyruvate carboxykinase (diphosphate) activity
namespace: molecular_function
def: "Catalysis of the reaction: diphosphate + oxaloacetate = CO(2) + phosphate + phosphoenolpyruvate." [EC:4.1.1.38, RHEA:22359]
synonym: "diphosphate:oxaloacetate carboxy-lyase (transphosphorylating)" EXACT [EC:4.1.1.38]
synonym: "diphosphate:oxaloacetate carboxy-lyase (transphosphorylating; phosphoenolpyruvate-forming)" EXACT [EC:4.1.1.38]
synonym: "PEP carboxyphosphotransferase activity" EXACT [EC:4.1.1.38]
synonym: "PEPCTrP" RELATED [EC:4.1.1.38]
synonym: "phosphoenolpyruvate carboxykinase (pyrophosphate) activity" EXACT [EC:4.1.1.38]
synonym: "phosphoenolpyruvate carboxylase (pyrophosphate)" EXACT [EC:4.1.1.38]
synonym: "phosphoenolpyruvate carboxyphosphotransferase activity" EXACT [EC:4.1.1.38]
synonym: "phosphoenolpyruvate carboxytransphosphorylase activity" EXACT [EC:4.1.1.38]
synonym: "phosphoenolpyruvic carboxykinase" BROAD [EC:4.1.1.38]
synonym: "phosphoenolpyruvic carboxykinase (pyrophosphate)" EXACT [EC:4.1.1.38]
synonym: "phosphoenolpyruvic carboxylase (pyrophosphate)" EXACT [EC:4.1.1.38]
synonym: "phosphoenolpyruvic carboxytransphosphorylase activity" EXACT [EC:4.1.1.38]
synonym: "phosphopyruvate carboxykinase" BROAD [EC:4.1.1.38]
synonym: "phosphopyruvate carboxykinase (pyrophosphate)" EXACT [EC:4.1.1.38]
synonym: "phosphopyruvate carboxylase (pyrophosphate)" EXACT [EC:4.1.1.38]
xref: EC:4.1.1.38
xref: KEGG:R00346
xref: MetaCyc:4.1.1.38-RXN
xref: RHEA:22359
is_a: GO:0004611 ! phosphoenolpyruvate carboxykinase activity

[Term]
id: GO:0030586
name: [methionine synthase] reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: [methionine synthase]-cob(II)alamin + NADPH + H+ + S-adenosyl methionine = [methionine synthase]-methylcob(I)alamin + S-adenosylhomocysteine + NADP+." [EC:1.16.1.8]
comment: Note that this was EC:2.1.1.135.
synonym: "5-methyltetrahydrofolate-homocysteine methyltransferase reductase" RELATED []
synonym: "[methionine synthase]-cobalamin methyltransferase (cob(II)alamin reducing) activity" EXACT []
synonym: "methionine synthase cob(II)alamin reductase (methylating) activity" EXACT [EC:1.16.1.8]
synonym: "methionine synthase reductase activity" EXACT [EC:1.16.1.8]
synonym: "methionine synthase-cobalamin methyltransferase (cob(II)alamin reducing)" EXACT [EC:1.16.1.8]
synonym: "methionine synthase-methylcob(I)alamin,S-adenosylhomocysteine:NADP+ oxidoreductase activity" EXACT [EC:1.16.1.8]
xref: EC:1.16.1.8
xref: MetaCyc:2.1.1.135-RXN
is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor

[Term]
id: GO:0030587
name: sorocarp development
namespace: biological_process
def: "The process whose specific outcome is the progression of the sorocarp over time, from its formation to the mature structure. The process begins with the aggregation of individual cells and ends with the mature sorocarp. The sorocarp is a structure containing a spore-bearing sorus that sits on top of a stalk. An example of this process is found in Dictyostelium discoideum." [dictyBase_REF:2530, GOC:mah, GOC:mtg_sensu, ISBN:0521583640]
synonym: "fruiting body development" BROAD []
synonym: "fruiting body formation" BROAD []
synonym: "sorocarp biosynthesis" EXACT []
synonym: "sorocarp formation" EXACT []
is_a: GO:0009267 ! cellular response to starvation
is_a: GO:0030582 ! fruiting body development
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0019954 ! asexual reproduction

[Term]
id: GO:0030588
name: pseudocleavage
namespace: biological_process
def: "Partial constriction of the cytoplasm of an embryo to form a furrow that resembles a cleavage furrow but does not complete cytokinesis." [GOC:mah, PMID:10751167, PMID:7729583]
is_a: GO:0044707 ! single-multicellular organism process
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0009790 ! embryo development

[Term]
id: GO:0030589
name: pseudocleavage involved in syncytial blastoderm formation
namespace: biological_process
def: "Formation of furrows in the cytoplasm between nuclei during cell cycles in embryos that contribute to the formation of the syncytial blastoderm. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu]
synonym: "pseudocleavage during syncytial blastoderm formation" RELATED [GOC:dph]
is_a: GO:0030588 ! pseudocleavage
relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm

[Term]
id: GO:0030590
name: first cell cycle pseudocleavage
namespace: biological_process
def: "A process that occurs during the first cell cycle in an embryo, in which anterior cortical contractions culminate in a single partial constriction of the embryo called the pseudocleavage furrow. An example of this process is found in nematode worms." [GOC:mtg_sensu, PMID:7729583]
is_a: GO:0030588 ! pseudocleavage

[Term]
id: GO:0030591
name: NAD DNA ADP-ribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of the ADP-ribose group of NAD+ to the amino group at N2 of 2'-deoxyguanosine to yield N2-(alpha-ADP-ribos-1-yl)-2'-deoxyguanosine and its beta form." [PMID:11592983]
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0030592
name: DNA ADP-ribosylation
namespace: biological_process
def: "The covalent attachment of an ADP-ribosyl group to the amino group at N2 of a 2'-deoxyguanosine residue in double-stranded DNA." [PMID:11592983]
subset: gosubset_prok
is_a: GO:0006304 ! DNA modification

[Term]
id: GO:0030593
name: neutrophil chemotaxis
namespace: biological_process
def: "The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding." [GOC:jl, ISBN:0198506732]
is_a: GO:0071621 ! granulocyte chemotaxis
is_a: GO:1990266 ! neutrophil migration

[Term]
id: GO:0030594
name: neurotransmitter receptor activity
namespace: molecular_function
def: "Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]
subset: goslim_synapse
is_a: GO:0038023 ! signaling receptor activity
intersection_of: GO:0004872 ! receptor activity
intersection_of: part_of GO:0007268 ! synaptic transmission
relationship: has_part GO:0042165 ! neurotransmitter binding
relationship: occurs_in GO:0045211 ! postsynaptic membrane
relationship: part_of GO:0007268 ! synaptic transmission
relationship: part_of GO:0099565 ! chemical synaptic transmission, postsynaptic

[Term]
id: GO:0030595
name: leukocyte chemotaxis
namespace: biological_process
def: "The movement of a leukocyte in response to an external stimulus." [GOC:add, GOC:jl]
synonym: "immune cell chemotaxis" EXACT []
synonym: "leucocyte chemotaxis" EXACT []
is_a: GO:0050900 ! leukocyte migration
is_a: GO:0060326 ! cell chemotaxis

[Term]
id: GO:0030596
name: alpha-L-rhamnosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides." [EC:3.2.1.40]
subset: gosubset_prok
synonym: "alpha-L-rhamnosidase N" RELATED [EC:3.2.1.40]
synonym: "alpha-L-rhamnosidase T" RELATED [EC:3.2.1.40]
synonym: "alpha-L-rhamnoside rhamnohydrolase activity" EXACT [EC:3.2.1.40]
xref: EC:3.2.1.40
xref: MetaCyc:3.2.1.40-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0030597
name: RNA glycosylase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of N-glycosidic bonds in an RNA molecule." [GOC:mah]
subset: gosubset_prok
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0030598
name: rRNA N-glycosylase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the N-glycosylic bond at A-4324 in 28S rRNA from rat ribosomes or corresponding sites in 28S RNA from other species." [EC:3.2.2.22, GOC:mah]
subset: gosubset_prok
synonym: "gelonin" RELATED [EC:3.2.2.22]
synonym: "mirabilis antiviral protein" RELATED [EC:3.2.2.22]
synonym: "momorcochin-S" RELATED [EC:3.2.2.22]
synonym: "nigrin b" RELATED [EC:3.2.2.22]
synonym: "ribosomal ribonucleate N-glycosidase activity" EXACT [EC:3.2.2.22]
synonym: "ricin" RELATED [EC:3.2.2.22]
synonym: "RNA N-glycosidase activity" EXACT [EC:3.2.2.22]
synonym: "rRNA N-glycohydrolase activity" EXACT [EC:3.2.2.22]
synonym: "rRNA N-glycosidase activity" EXACT []
synonym: "saporins" RELATED [EC:3.2.2.22]
xref: EC:3.2.2.22
xref: MetaCyc:3.2.2.22-RXN
is_a: GO:0030597 ! RNA glycosylase activity

[Term]
id: GO:0030599
name: pectinesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: pectin + n H2O = n methanol + pectate." [EC:3.1.1.11]
subset: gosubset_prok
synonym: "pectase activity" EXACT [EC:3.1.1.11]
synonym: "pectin demethoxylase activity" EXACT [EC:3.1.1.11]
synonym: "pectin methoxylase activity" EXACT [EC:3.1.1.11]
synonym: "pectin methyl esterase activity" EXACT [EC:3.1.1.11]
synonym: "pectin methylesterase activity" EXACT []
synonym: "pectin pectylhydrolase activity" EXACT [EC:3.1.1.11]
synonym: "pectinoesterase activity" EXACT [EC:3.1.1.11]
xref: EC:3.1.1.11
xref: MetaCyc:PECTINESTERASE-RXN
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0030600
name: feruloyl esterase activity
namespace: molecular_function
def: "Catalysis of the reaction: feruloyl-polysaccharide + H2O = ferulate + polysaccharide." [EC:3.1.1.73]
synonym: "4-hydroxy-3-methoxycinnamoyl-sugar hydrolase activity" EXACT [EC:3.1.1.73]
synonym: "cinnAE" RELATED [EC:3.1.1.73]
synonym: "cinnamoyl ester hydrolase activity" EXACT []
synonym: "FAE-I" RELATED [EC:3.1.1.73]
synonym: "FAE-II" RELATED [EC:3.1.1.73]
synonym: "FAE-III" RELATED [EC:3.1.1.73]
synonym: "FAEA" RELATED [EC:3.1.1.73]
synonym: "ferulic acid esterase activity" EXACT [EC:3.1.1.73]
synonym: "hemicellulase accessory" RELATED [EC:3.1.1.73]
synonym: "hydroxycinnamoyl esterase activity" EXACT [EC:3.1.1.73]
xref: EC:3.1.1.73
xref: MetaCyc:3.1.1.73-RXN
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0030601
name: obsolete aminopeptidase B activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of N-terminal Arg and Lys from oligopeptides when P1' is not Pro. Also acts on arylamides of Arg and Lys." [EC:3.4.11.6]
comment: This term was made obsolete because it represents a gene product.
synonym: "aminopeptidase B activity" EXACT []
synonym: "arginyl aminopeptidase activity" EXACT []
synonym: "arylamidase II" RELATED [EC:3.4.11.6]
synonym: "Cl--activated arginine aminopeptidase activity" EXACT [EC:3.4.11.6]
synonym: "cytosol aminopeptidase IV" RELATED [EC:3.4.11.6]
synonym: "L-arginine aminopeptidase activity" EXACT [EC:3.4.11.6]
xref: EC:3.4.11.6
xref: MetaCyc:3.4.11.6-RXN
is_obsolete: true
replaced_by: GO:0004177

[Term]
id: GO:0030602
name: obsolete chymosin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the lysis of peptide bonds with broad specificity similar to that of pepsin A. Clots milk by cleavage of a single Ser-Phe-l-Met-Ala bond in kappa-casein." [EC:3.4.23.4]
comment: This term was made obsolete because it represents a gene product.
synonym: "chymosin activity" EXACT []
synonym: "rennin" RELATED [EC:3.4.23.4]
synonym: "rennin (but this should be avoided since it leads to confusion with renin)" RELATED [EC:3.4.23.4]
xref: EC:3.4.23.4
xref: MetaCyc:3.4.23.4-RXN
is_obsolete: true
replaced_by: GO:0004190

[Term]
id: GO:0030603
name: oxaloacetase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + oxaloacetate = acetate + H(+) + oxalate." [EC:3.7.1.1, RHEA:24435]
synonym: "oxalacetic hydrolase activity" EXACT [EC:3.7.1.1]
synonym: "oxaloacetate acetylhydrolase activity" EXACT [EC:3.7.1.1]
xref: EC:3.7.1.1
xref: KEGG:R00338
xref: MetaCyc:OXALOACETASE-RXN
xref: RHEA:24435
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0030604
name: 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH." [EC:1.1.1.267, RHEA:13720]
subset: gosubset_prok
synonym: "1-deoxy-D-xylulose-5-phosphate isomeroreductase activity" EXACT [EC:1.1.1.267]
synonym: "1-deoxyxylulose-5-phosphate reductoisomerase activity" EXACT [EC:1.1.1.267]
synonym: "2-C-methyl-D-erythritol-4-phosphate:NADP+ oxidoreductase (isomerizing)" EXACT [EC:1.1.1.267]
synonym: "2C-methyl-D-erythritol-4-phosphate (MEP) synthase activity" EXACT [EC:1.1.1.267]
synonym: "DOXP reductoisomerase activity" EXACT []
synonym: "DXP-reductoisomerase activity" EXACT [EC:1.1.1.267]
xref: EC:1.1.1.267
xref: KEGG:R05688
xref: MetaCyc:DXPREDISOM-RXN
xref: RHEA:13720
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0030611
name: arsenate reductase activity
namespace: molecular_function
def: "Catalysis of the interconversion of arsenate and arsenite." [GOC:mah]
subset: gosubset_prok
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0030612
name: arsenate reductase (thioredoxin) activity
namespace: molecular_function
def: "Catalysis of the reaction: arsenate + thioredoxin = arsenite + thioredoxin disulfide. Thioredoxin disulfide is also known as oxidized thioredoxin." [MetaCyc:RXN-10737]
xref: MetaCyc:RXN-10737
is_a: GO:0030611 ! arsenate reductase activity

[Term]
id: GO:0030613
name: oxidoreductase activity, acting on phosphorus or arsenic in donors
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:mah]
comment: Note that enzymes of class EC:1.20.99.- should also be annotated to this term.
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on phosphorus or arsenic in donors, with other acceptors" NARROW []
xref: EC:1.20
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0030614
name: oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a disulfide." [GOC:mah]
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on phosphorus or arsenic in donors, with disulphide as acceptor" EXACT []
xref: EC:1.20.4
is_a: GO:0030613 ! oxidoreductase activity, acting on phosphorus or arsenic in donors

[Term]
id: GO:0030616
name: transforming growth factor beta receptor, common-partner cytoplasmic mediator activity
namespace: molecular_function
def: "A TGF-beta cytoplasmic mediator that forms a complex with a phosphorylated pathway-specific mediator. The heterocomplex translocates to the nucleus to regulate transcription." [GOC:hjd]
comment: Note that this term can be used in place of the obsolete molecular function term 'common-partner SMAD protein ; GO:0005073' and is useful for annotating proteins of the SMAD family.
synonym: "common-partner SMAD protein" RELATED []
synonym: "TGF-beta receptor, common-partner cytoplasmic mediator activity" EXACT []
synonym: "TGFbeta receptor, common-partner cytoplasmic mediator activity" EXACT []
is_a: GO:0005072 ! transforming growth factor beta receptor, cytoplasmic mediator activity

[Term]
id: GO:0030617
name: transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity
namespace: molecular_function
def: "A TGF-beta cytoplasmic mediator that inhibits the signaling function of common-partner and pathway-specific mediators." [PMID:9759503]
comment: Note that this term can be used in place of the obsolete molecular function term 'inhibitory SMAD protein ; GO:0005074' and is useful for annotating proteins of the SMAD family.
synonym: "inhibitory SMAD protein" RELATED []
synonym: "TGF-beta receptor, inhibitory cytoplasmic mediator activity" EXACT []
synonym: "TGFbeta receptor, inhibitory cytoplasmic mediator activity" EXACT []
is_a: GO:0005072 ! transforming growth factor beta receptor, cytoplasmic mediator activity

[Term]
id: GO:0030618
name: transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
namespace: molecular_function
def: "A TGF-beta cytoplasmic mediator that is phosphorylated by a TGFbeta receptor and complexes with a common-partner mediator. The- heterocomplex translocates to the nucleus to regulate transcription." [GOC:hjd]
comment: Note that this term can be used in place of the obsolete molecular function term 'pathway-specific SMAD protein ; GO:0005075' and is useful for annotating proteins of the SMAD family.
synonym: "pathway-specific SMAD protein" NARROW []
synonym: "TGF-beta receptor, pathway-specific cytoplasmic mediator activity" EXACT []
synonym: "TGFbeta receptor, pathway-specific cytoplasmic mediator activity" EXACT []
is_a: GO:0005072 ! transforming growth factor beta receptor, cytoplasmic mediator activity

[Term]
id: GO:0030619
name: U1 snRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the U1 small nuclear RNA (U1 snRNA)." [GOC:mah]
comment: Note that this term may be useful for annotating other small nuclear RNAs (snRNAs).
is_a: GO:0017069 ! snRNA binding

[Term]
id: GO:0030620
name: U2 snRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the U2 small nuclear RNA (U2 snRNA)." [GOC:jl]
is_a: GO:0017069 ! snRNA binding

[Term]
id: GO:0030621
name: U4 snRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the U4 small nuclear RNA (U4 snRNA)." [GOC:jl]
is_a: GO:0017069 ! snRNA binding

[Term]
id: GO:0030622
name: U4atac snRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the U4atac small nuclear RNA (U4atac snRNA)." [GOC:jl]
is_a: GO:0017069 ! snRNA binding

[Term]
id: GO:0030623
name: U5 snRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the U5 small nuclear RNA (U5 snRNA)." [GOC:jl]
is_a: GO:0017069 ! snRNA binding

[Term]
id: GO:0030624
name: U6atac snRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the U6atac small nuclear RNA (U6atac snRNA)." [GOC:jl]
is_a: GO:0017069 ! snRNA binding

[Term]
id: GO:0030625
name: U11 snRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the U11 small nuclear RNA (U11 snRNA)." [GOC:jl]
is_a: GO:0017069 ! snRNA binding

[Term]
id: GO:0030626
name: U12 snRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the U12 small nuclear RNA (U12 snRNA)." [GOC:jl]
is_a: GO:0017069 ! snRNA binding

[Term]
id: GO:0030627
name: pre-mRNA 5'-splice site binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the pre-mRNA 5' splice site sequence." [GOC:jl]
synonym: "pre-mRNA 5' splice site binding" EXACT []
is_a: GO:0036002 ! pre-mRNA binding

[Term]
id: GO:0030628
name: pre-mRNA 3'-splice site binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the pre-mRNA 3' splice site sequence." [GOC:jl]
synonym: "pre-mRNA 3' splice site binding" EXACT []
is_a: GO:0036002 ! pre-mRNA binding

[Term]
id: GO:0030629
name: U6 snRNA 3'-end binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the 3' end of the U6 small nuclear RNA (U6 snRNA)." [GOC:mah]
comment: Note that this term may be useful for annotating small nuclear RNAs (snRNAs).
synonym: "U6 snRNA 3' end binding" EXACT []
is_a: GO:0017070 ! U6 snRNA binding

[Term]
id: GO:0030631
name: pyrrolysine incorporation
namespace: biological_process
def: "The incorporation of pyrrolysine, also known as lysine methylamine methyltransferase cofactor adduct, into a peptide; uses a special tRNA that recognizes the UAG codon as a modified lysine, rather than as a termination codon. Pyrrolysine may be synthesized as a free amino acid or synthesized from a lysine charged tRNA before its incorporation; it is not a posttranslational modification of peptidyl-lysine; this modification is found in several Methanosarcina methylamine methyltransferases." [PMID:11435424, PMID:17204561, RESID:AA0321]
subset: gosubset_prok
synonym: "lysine methylamine methyltransferase cofactor adduct incorporation" EXACT [RESID:AA0321]
synonym: "monomethylamine methyltransferase cofactor lysine adduct incorporation" EXACT [CHEBI:21860]
xref: RESID:AA0321
is_a: GO:0006451 ! translational readthrough

[Term]
id: GO:0030632
name: D-alanine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of D-alanine, the D-enantiomer of the amino acid alanine, i.e (2R)-2-aminopropanoic acid." [CHEBI:15570, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "D-alanine anabolism" EXACT []
synonym: "D-alanine biosynthesis" EXACT []
synonym: "D-alanine formation" EXACT []
synonym: "D-alanine synthesis" EXACT []
is_a: GO:0046145 ! D-alanine family amino acid biosynthetic process
is_a: GO:0046436 ! D-alanine metabolic process
is_a: GO:0046437 ! D-amino acid biosynthetic process

[Term]
id: GO:0030633
name: D-alanine family amino acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-alanine and related amino acids." [GOC:mah]
subset: gosubset_prok
synonym: "D-alanine family amino acid breakdown" EXACT []
synonym: "D-alanine family amino acid catabolism" EXACT []
synonym: "D-alanine family amino acid degradation" EXACT []
is_a: GO:0006524 ! alanine catabolic process
is_a: GO:0046144 ! D-alanine family amino acid metabolic process

[Term]
id: GO:0030634
name: carbon fixation by acetyl-CoA pathway
namespace: biological_process
def: "A pathway of carbon dioxide fixation in which one molecule of acetyl-CoA is completely synthesized from two molecules of carbon dioxide (CO2)." [PMID:11607093]
subset: gosubset_prok
synonym: "Ljungdahl-Wood pathway" EXACT []
is_a: GO:0006085 ! acetyl-CoA biosynthetic process
is_a: GO:0015977 ! carbon fixation
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0030635
name: obsolete acetate derivative metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving derivatives of acetic acid." [GOC:mah]
comment: This term was made obsolete because it is an unnecessary grouping term, and has been replaced by terms to describe metabolism of specific compounds.
subset: gosubset_prok
synonym: "acetate derivative metabolic process" EXACT []
synonym: "acetate derivative metabolism" EXACT []
is_obsolete: true
consider: GO:1900619

[Term]
id: GO:0030636
name: obsolete acetate derivative biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of derivatives of acetic acid." [GOC:mah]
comment: This term was made obsolete because it is an unnecessary grouping term and has been replaced by terms to describe metabolism of specific compounds.
subset: gosubset_prok
synonym: "acetate derivative anabolism" EXACT []
synonym: "acetate derivative biosynthesis" EXACT []
synonym: "acetate derivative biosynthetic process" EXACT []
synonym: "acetate derivative formation" EXACT []
synonym: "acetate derivative synthesis" EXACT []
is_obsolete: true
consider: GO:1900620

[Term]
id: GO:0030637
name: obsolete acetate derivative catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of derivatives of acetic acid." [GOC:ai]
comment: This term was made obsolete because it is an unnecessary grouping term and has been replaced by terms to describe metabolism of specific compounds.
subset: gosubset_prok
synonym: "acetate derivative breakdown" EXACT []
synonym: "acetate derivative catabolic process" EXACT []
synonym: "acetate derivative catabolism" EXACT []
synonym: "acetate derivative degradation" EXACT []
is_obsolete: true

[Term]
id: GO:0030638
name: polyketide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty acid biosynthesis but without the intermediate reductive steps." [GOC:mah, ISBN:0198506732]
subset: gosubset_prok
synonym: "polyketide metabolism" EXACT []
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0071704 ! organic substance metabolic process

[Term]
id: GO:0030639
name: polyketide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty acid biosynthesis but without the intermediate reductive steps." [GOC:mah, ISBN:0198506732]
subset: gosubset_prok
synonym: "polyketide anabolism" EXACT []
synonym: "polyketide biosynthesis" EXACT []
synonym: "polyketide formation" EXACT []
synonym: "polyketide synthesis" EXACT []
is_a: GO:0030638 ! polyketide metabolic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:1901576 ! organic substance biosynthetic process

[Term]
id: GO:0030640
name: polyketide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty acid biosynthesis but without the intermediate reductive steps." [GOC:mah, ISBN:0198506732]
subset: gosubset_prok
synonym: "polyketide breakdown" EXACT []
synonym: "polyketide catabolism" EXACT []
synonym: "polyketide degradation" EXACT []
is_a: GO:0030638 ! polyketide metabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1901575 ! organic substance catabolic process

[Term]
id: GO:0030641
name: regulation of cellular pH
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of hydrogen ions (protons) within a cell or between a cell and its external environment." [GOC:dph, GOC:mah, GOC:tb]
subset: gosubset_prok
synonym: "cellular hydrogen ion homeostasis" EXACT [GOC:dph, GOC:tb]
synonym: "proton homeostasis" EXACT []
is_a: GO:0006885 ! regulation of pH
is_a: GO:0030004 ! cellular monovalent inorganic cation homeostasis

[Term]
id: GO:0030642
name: cellular sulfate ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of sulfate ions at the level of a cell." [GOC:mah]
synonym: "sulphate ion homeostasis" BROAD []
is_a: GO:0055063 ! sulfate ion homeostasis
is_a: GO:0072501 ! cellular divalent inorganic anion homeostasis

[Term]
id: GO:0030643
name: cellular phosphate ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of phosphate ions at the level of a cell." [GOC:mah]
is_a: GO:0030320 ! cellular monovalent inorganic anion homeostasis
is_a: GO:0055062 ! phosphate ion homeostasis
is_a: GO:0072501 ! cellular divalent inorganic anion homeostasis
is_a: GO:0072502 ! cellular trivalent inorganic anion homeostasis

[Term]
id: GO:0030644
name: cellular chloride ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of chloride ions at the level of a cell." [GOC:mah]
is_a: GO:0030320 ! cellular monovalent inorganic anion homeostasis
is_a: GO:0055064 ! chloride ion homeostasis

[Term]
id: GO:0030645
name: glucose catabolic process to butyrate
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glucose, with the production of acetic acid, butyric acid, carbon dioxide (CO2), and dihydrogen; effected by some saccharolytic species of Clostridium, e.g. C. butyricum." [ISBN:0198506732]
subset: gosubset_prok
synonym: "butyrate fermentation" EXACT []
synonym: "glucose fermentation to butyrate" EXACT []
is_a: GO:0006007 ! glucose catabolic process
is_a: GO:0006113 ! fermentation
is_a: GO:1902705 ! hexose catabolic process to butyrate

[Term]
id: GO:0030647
name: aminoglycoside antibiotic metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin." [GOC:mah, ISBN:0198506732]
subset: gosubset_prok
synonym: "aminoglycoside antibiotic metabolism" EXACT []
is_a: GO:0016137 ! glycoside metabolic process

[Term]
id: GO:0030648
name: aminoglycoside antibiotic biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin." [GOC:mah, ISBN:0198506732]
subset: gosubset_prok
synonym: "aminoglycoside antibiotic anabolism" EXACT []
synonym: "aminoglycoside antibiotic biosynthesis" EXACT []
synonym: "aminoglycoside antibiotic formation" EXACT []
synonym: "aminoglycoside antibiotic synthesis" EXACT []
is_a: GO:0016138 ! glycoside biosynthetic process
is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0030647 ! aminoglycoside antibiotic metabolic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0030649
name: aminoglycoside antibiotic catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin." [GOC:mah, ISBN:0198506732]
subset: gosubset_prok
synonym: "aminoglycoside antibiotic breakdown" EXACT []
synonym: "aminoglycoside antibiotic catabolism" EXACT []
synonym: "aminoglycoside antibiotic degradation" EXACT []
is_a: GO:0016139 ! glycoside catabolic process
is_a: GO:0017001 ! antibiotic catabolic process
is_a: GO:0030647 ! aminoglycoside antibiotic metabolic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0030650
name: peptide antibiotic metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving peptides with antibiotic activity." [GOC:mah]
subset: gosubset_prok
synonym: "peptide antibiotic metabolism" EXACT []
is_a: GO:0006518 ! peptide metabolic process
is_a: GO:0016999 ! antibiotic metabolic process

[Term]
id: GO:0030651
name: peptide antibiotic biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of peptides with antibiotic activity." [GOC:mah]
subset: gosubset_prok
synonym: "peptide antibiotic anabolism" EXACT []
synonym: "peptide antibiotic biosynthesis" EXACT []
synonym: "peptide antibiotic formation" EXACT []
synonym: "peptide antibiotic synthesis" EXACT []
is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0030650 ! peptide antibiotic metabolic process
is_a: GO:0043043 ! peptide biosynthetic process

[Term]
id: GO:0030652
name: peptide antibiotic catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of peptides with antibiotic activity." [GOC:mah]
subset: gosubset_prok
synonym: "peptide antibiotic breakdown" EXACT []
synonym: "peptide antibiotic catabolism" EXACT []
synonym: "peptide antibiotic degradation" EXACT []
is_a: GO:0017001 ! antibiotic catabolic process
is_a: GO:0030650 ! peptide antibiotic metabolic process
is_a: GO:0043171 ! peptide catabolic process

[Term]
id: GO:0030653
name: beta-lactam antibiotic metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a beta-lactam antibiotic, any member of a class of natural or semisynthetic antibiotics whose characteristic feature is a strained, four-membered beta-lactam ring. They include the penicillins and many of the cephalosporins." [GOC:mah, ISBN:0198506732]
subset: gosubset_prok
synonym: "beta-lactam antibiotic metabolism" EXACT []
is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0044106 ! cellular amine metabolic process
is_a: GO:0072338 ! cellular lactam metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process

[Term]
id: GO:0030654
name: beta-lactam antibiotic biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a beta-lactam antibiotic, any member of a class of natural or semisynthetic antibiotics whose characteristic feature is a strained, four-membered beta-lactam ring. They include the penicillins and many of the cephalosporins." [GOC:mah, ISBN:0198506732]
subset: gosubset_prok
synonym: "beta-lactam antibiotic anabolism" EXACT []
synonym: "beta-lactam antibiotic biosynthesis" EXACT []
synonym: "beta-lactam antibiotic formation" EXACT []
synonym: "beta-lactam antibiotic synthesis" EXACT []
is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0030653 ! beta-lactam antibiotic metabolic process
is_a: GO:0072339 ! cellular lactam biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process

[Term]
id: GO:0030655
name: beta-lactam antibiotic catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a beta-lactam antibiotic, any member of a class of natural or semisynthetic antibiotics whose characteristic feature is a strained, four-membered beta-lactam ring. They include the penicillins and many of the cephalosporins." [GOC:mah, ISBN:0198506732]
subset: gosubset_prok
synonym: "beta-lactam antibiotic breakdown" EXACT []
synonym: "beta-lactam antibiotic catabolism" EXACT []
synonym: "beta-lactam antibiotic degradation" EXACT []
is_a: GO:0017001 ! antibiotic catabolic process
is_a: GO:0030653 ! beta-lactam antibiotic metabolic process
is_a: GO:0072340 ! cellular lactam catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process

[Term]
id: GO:0030656
name: regulation of vitamin metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of vitamin metabolism" EXACT []
is_a: GO:0019222 ! regulation of metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006766 ! vitamin metabolic process
relationship: regulates GO:0006766 ! vitamin metabolic process

[Term]
id: GO:0030657
name: obsolete regulation of coenzyme and prosthetic group metabolic process
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving coenzymes and prosthetic groups." [GOC:ai]
comment: This term was made obsolete because it was replaced by more specific terms.
synonym: "regulation of coenzyme and prosthetic group metabolic process" EXACT []
is_obsolete: true
consider: GO:0051196
consider: GO:0051199

[Term]
id: GO:0030658
name: transport vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a transport vesicle." [GOC:mah]
synonym: "constitutive secretory pathway transport vesicle membrane" EXACT []
synonym: "secretory vesicle membrane" BROAD []
is_a: GO:0030659 ! cytoplasmic vesicle membrane
is_a: GO:0098588 ! bounding membrane of organelle
is_a: GO:0098805 ! whole membrane
relationship: part_of GO:0030133 ! transport vesicle

[Term]
id: GO:0030659
name: cytoplasmic vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a cytoplasmic vesicle." [GOC:mah]
subset: gosubset_prok
is_a: GO:0012506 ! vesicle membrane
is_a: GO:0044433 ! cytoplasmic vesicle part
relationship: part_of GO:0016023 ! cytoplasmic, membrane-bounded vesicle

[Term]
id: GO:0030660
name: Golgi-associated vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a vesicle associated with the Golgi apparatus." [GOC:mah]
synonym: "Golgi vesicle membrane" RELATED []
is_a: GO:0000139 ! Golgi membrane
is_a: GO:0030659 ! cytoplasmic vesicle membrane
is_a: GO:0098805 ! whole membrane
relationship: part_of GO:0005798 ! Golgi-associated vesicle

[Term]
id: GO:0030661
name: chitosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a chitosome." [GOC:mah]
is_a: GO:0030659 ! cytoplasmic vesicle membrane
is_a: GO:0098588 ! bounding membrane of organelle
is_a: GO:0098805 ! whole membrane
relationship: part_of GO:0045009 ! chitosome

[Term]
id: GO:0030662
name: coated vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a coated vesicle." [GOC:mah]
is_a: GO:0030659 ! cytoplasmic vesicle membrane
is_a: GO:0098588 ! bounding membrane of organelle
is_a: GO:0098805 ! whole membrane
relationship: part_of GO:0030135 ! coated vesicle

[Term]
id: GO:0030663
name: COPI-coated vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a COPI-coated vesicle." [GOC:mah]
synonym: "COPI coated vesicle membrane" EXACT [GOC:sl]
is_a: GO:0030660 ! Golgi-associated vesicle membrane
is_a: GO:0030662 ! coated vesicle membrane
relationship: part_of GO:0030137 ! COPI-coated vesicle

[Term]
id: GO:0030665
name: clathrin-coated vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a clathrin-coated vesicle." [GOC:mah]
synonym: "clathrin coated vesicle membrane" NARROW [GOC:sl]
is_a: GO:0030662 ! coated vesicle membrane
relationship: part_of GO:0030136 ! clathrin-coated vesicle

[Term]
id: GO:0030666
name: endocytic vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding an endocytic vesicle." [GOC:mah]
is_a: GO:0030659 ! cytoplasmic vesicle membrane
is_a: GO:0098588 ! bounding membrane of organelle
is_a: GO:0098805 ! whole membrane
relationship: part_of GO:0030139 ! endocytic vesicle

[Term]
id: GO:0030667
name: secretory granule membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a secretory granule." [GOC:mah]
synonym: "secretory vesicle membrane" BROAD []
is_a: GO:0030659 ! cytoplasmic vesicle membrane
is_a: GO:0098588 ! bounding membrane of organelle
is_a: GO:0098805 ! whole membrane
relationship: part_of GO:0030141 ! secretory granule

[Term]
id: GO:0030668
name: merozoite dense granule membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a dense granule of the type found in apicomplexan parasites." [GOC:mah, GOC:mtg_sensu]
is_a: GO:0030659 ! cytoplasmic vesicle membrane
is_a: GO:0098588 ! bounding membrane of organelle
is_a: GO:0098805 ! whole membrane
relationship: part_of GO:0020026 ! merozoite dense granule

[Term]
id: GO:0030669
name: clathrin-coated endocytic vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a clathrin-coated endocytic vesicle." [GOC:mah]
is_a: GO:0030665 ! clathrin-coated vesicle membrane
is_a: GO:0030666 ! endocytic vesicle membrane
relationship: part_of GO:0045334 ! clathrin-coated endocytic vesicle

[Term]
id: GO:0030670
name: phagocytic vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a phagocytic vesicle." [GOC:mah]
synonym: "phagosome membrane" EXACT [GOC:mah]
is_a: GO:0030666 ! endocytic vesicle membrane
relationship: part_of GO:0045335 ! phagocytic vesicle

[Term]
id: GO:0030671
name: clathrin-coated phagocytic vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a clathrin-coated phagocytic vesicle." [GOC:mah]
is_a: GO:0030669 ! clathrin-coated endocytic vesicle membrane
is_a: GO:0030670 ! phagocytic vesicle membrane
relationship: part_of GO:0045336 ! clathrin-coated phagocytic vesicle

[Term]
id: GO:0030672
name: synaptic vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a synaptic vesicle." [GOC:mah]
subset: goslim_synapse
is_a: GO:0044456 ! synapse part
is_a: GO:0097458 ! neuron part
is_a: GO:0099501 ! exocytic vesicle membrane
relationship: part_of GO:0008021 ! synaptic vesicle

[Term]
id: GO:0030673
name: axolemma
namespace: cellular_component
def: "The portion of the plasma membrane surrounding an axon; it is a specialized trilaminar random mosaic of protein molecules floating within a fluid matrix of highly mobile phospholipid molecules, 7-8 nm in thickness." [http://www.medik.sk/clanky/bio_jun.htm, ISBN:0124325653]
synonym: "axonal membrane" EXACT [GOC:vk]
xref: NIF_Subcellular:sao250772229
xref: Wikipedia:Axolemma
is_a: GO:0032589 ! neuron projection membrane
is_a: GO:0033267 ! axon part
relationship: part_of GO:0044304 ! main axon

[Term]
id: GO:0030674
name: protein binding, bridging
namespace: molecular_function
def: "The binding activity of a molecule that brings together two or more protein molecules, or a protein and another macromolecule or complex, through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:bf, GOC:mah, GOC:vw]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_yeast
subset: gosubset_prok
synonym: "protein-protein adaptor" NARROW []
is_a: GO:0005515 ! protein binding
is_a: GO:0060090 ! binding, bridging

[Term]
id: GO:0030676
name: Rac guanyl-nucleotide exchange factor activity
namespace: molecular_function
def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rac family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
xref: Reactome:REACT_101876 "Activation of Rac1 by FARP2, Canis familiaris"
xref: Reactome:REACT_108612 "Activation of Rac1 by FARP2, Gallus gallus"
xref: Reactome:REACT_112997 "Activation of Rac1 by FARP2, Xenopus tropicalis"
xref: Reactome:REACT_19363 "Activation of Rac1 by FARP2, Homo sapiens"
xref: Reactome:REACT_30551 "Activation of Rac1 by FARP2, Rattus norvegicus"
xref: Reactome:REACT_82732 "Activation of Rac1 by FARP2, Bos taurus"
xref: Reactome:REACT_90439 "Activation of Rac1 by FARP2, Danio rerio"
xref: Reactome:REACT_98250 "Activation of Rac1 by FARP2, Drosophila melanogaster"
xref: Reactome:REACT_98803 "Activation of Rac1 by FARP2, Taeniopygia guttata"
is_a: GO:0005089 ! Rho guanyl-nucleotide exchange factor activity

[Term]
id: GO:0030677
name: ribonuclease P complex
namespace: cellular_component
def: "A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5' end of tRNAs." [GOC:mah, PMID:12045094]
comment: Note that chloroplasts possess a complex that is called 'RNase P' because it catalyzes pre-tRNA cleavage, but the chloroplast complex appears not to contain RNA.
subset: goslim_pir
subset: gosubset_prok
synonym: "RNase P complex" EXACT []
is_a: GO:0030529 ! intracellular ribonucleoprotein complex
is_a: GO:1902555 ! endoribonuclease complex

[Term]
id: GO:0030678
name: mitochondrial ribonuclease P complex
namespace: cellular_component
def: "A ribonuclease P complex located in the mitochondrion of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. The subunit composition of mitochondrial ribonuclease P complexes varies between species, but the complex often contains a single RNA molecule and a single protein molecule." [GOC:mah, PMID:12045094]
synonym: "mitochondrial RNase P complex" EXACT []
is_a: GO:0030677 ! ribonuclease P complex
is_a: GO:0098798 ! mitochondrial protein complex
intersection_of: GO:0030677 ! ribonuclease P complex
intersection_of: part_of GO:0005739 ! mitochondrion
relationship: part_of GO:0005739 ! mitochondrion

[Term]
id: GO:0030679
name: cyanelle ribonuclease P complex
namespace: cellular_component
def: "A ribonuclease P complex located in the cyanelle, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. The best characterized cyanelle ribonuclease P complex, from the alga Cyanophora paradoxa, contains a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules." [GOC:mah, PMID:12045094]
synonym: "cyanelle RNase P complex" EXACT []
is_a: GO:0030681 ! multimeric ribonuclease P complex
is_a: GO:0044435 ! plastid part
intersection_of: GO:0030677 ! ribonuclease P complex
intersection_of: part_of GO:0009842 ! cyanelle
relationship: part_of GO:0009842 ! cyanelle

[Term]
id: GO:0030680
name: dimeric ribonuclease P complex
namespace: cellular_component
def: "A ribonuclease P complex that contains a single RNA molecule that is necessary and usually sufficient for catalysis, and a single protein molecule. Examples of this complex are found in Bacterial species." [GOC:mah, PMID:12045094]
subset: gosubset_prok
synonym: "dimeric RNase P complex" EXACT []
is_a: GO:0030677 ! ribonuclease P complex

[Term]
id: GO:0030681
name: multimeric ribonuclease P complex
namespace: cellular_component
def: "A ribonuclease P complex that generally contains a single RNA molecule and several protein molecules. Examples of this complex are found in Archaeal species." [GOC:mah, PMID:11142368, PMID:12045094]
synonym: "multimeric RNase P complex" EXACT []
is_a: GO:0030677 ! ribonuclease P complex

[Term]
id: GO:0030682
name: evasion or tolerance of host defense response
namespace: biological_process
def: "Any process, either active or passive, by which an organism avoids or tolerates the effects of its host organism's defense response. The host defense response is mounted by the host in response to the presence of the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "evasion of host defence response" EXACT []
is_a: GO:0044415 ! evasion or tolerance of host defenses
is_a: GO:0051807 ! evasion or tolerance of defense response of other organism involved in symbiotic interaction

[Term]
id: GO:0030683
name: evasion or tolerance by virus of host immune response
namespace: biological_process
alt_id: GO:0019052
alt_id: GO:0019053
def: "Any process, either active or passive, by which a virus avoids the effects of the host organism's immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mah, GOC:pk]
subset: goslim_virus
synonym: "evasion by virus of host immune response" NARROW [GOC:bf, GOC:bm, GOC:jl]
synonym: "inhibition of extracellular antiviral response" EXACT []
synonym: "negative regulation by virus of extracellular antiviral response" EXACT []
synonym: "negative regulation by virus of intracellular antiviral response" EXACT []
synonym: "negative regulation of host extracellular antiviral response by virus" EXACT []
synonym: "negative regulation of host intracellular antiviral response by virus" EXACT []
synonym: "suppression by virus of host extracellular antiviral response" EXACT []
synonym: "suppression by virus of host immune response" NARROW [GOC:bf]
synonym: "suppression by virus of host intracellular antiviral response" EXACT []
synonym: "suppression of host extracellular antiviral response by virus" EXACT []
synonym: "suppression of host intracellular antiviral response by virus" EXACT []
synonym: "viral inhibition of intracellular antiviral response" EXACT []
xref: Reactome:REACT_6186 "Binding of NS1 to PKR, Homo sapiens"
xref: Reactome:REACT_6301 "Inhibition of Interferon Synthesis, Homo sapiens"
xref: Reactome:REACT_6320 "Inhibition of IFN-beta, Homo sapiens"
xref: Reactome:REACT_6339 "Binding of NS1 to dsRNA, Homo sapiens"
xref: Reactome:REACT_6350 "Inhibition of PKR, Homo sapiens"
is_a: GO:0019049 ! evasion or tolerance of host defenses by virus
is_a: GO:0020012 ! evasion or tolerance of host immune response
is_a: GO:0050687 ! negative regulation of defense response to virus
is_a: GO:0050690 ! regulation of defense response to virus by virus

[Term]
id: GO:0030684
name: preribosome
namespace: cellular_component
def: "Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed during ribosome biogenesis." [PMID:10567516]
subset: goslim_pir
is_a: GO:0030529 ! intracellular ribonucleoprotein complex

[Term]
id: GO:0030685
name: nucleolar preribosome
namespace: cellular_component
def: "Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed in the nucleolus during ribosome biogenesis." [PMID:10567516]
is_a: GO:0030684 ! preribosome
is_a: GO:0044452 ! nucleolar part
intersection_of: GO:0030684 ! preribosome
intersection_of: part_of GO:0005730 ! nucleolus
relationship: part_of GO:0005730 ! nucleolus

[Term]
id: GO:0030686
name: 90S preribosome
namespace: cellular_component
def: "A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [GOC:krc, GOC:vw, PMID:12150911, PMID:12957375, PMID:15120992]
is_a: GO:0030684 ! preribosome
relationship: has_part GO:0034455 ! t-UTP complex

[Term]
id: GO:0030687
name: preribosome, large subunit precursor
namespace: cellular_component
def: "A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit." [PMID:10567516]
comment: Note that this complex is 66S in Saccharomyces.
synonym: "66S preribosome" NARROW []
is_a: GO:0030684 ! preribosome

[Term]
id: GO:0030688
name: preribosome, small subunit precursor
namespace: cellular_component
def: "A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit." [PMID:10567516]
comment: Note that this complex is 43S in Saccharomyces.
synonym: "43S preribosome" NARROW []
is_a: GO:0030684 ! preribosome

[Term]
id: GO:0030689
name: Noc complex
namespace: cellular_component
def: "Any of several heterodimers containing one or two Noc proteins, associated with preribosomal complexes; involved in ribosome biogenesis." [PMID:12446671]
comment: Noc complexes exhibit a dynamic intranuclear location; consider also annotating to 'nucleolus ; GO:0005730' and/or 'nucleoplasm ; GO:0005654'. Note that the definition uses Saccharomyces gene product names because this complex has only been described in Saccharomyces cerevisiae and no other names have yet arisen; the term nevertheless can be used for analogous complexes in other eukaryotes, and the definition can be changed if better wording is found.
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0030690
name: Noc1p-Noc2p complex
namespace: cellular_component
def: "A heterodimer associated with 90S and 66S preribosomes. Predominantly, but not exclusively, nucleolar; involved in ribosomal large subunit biogenesis." [PMID:12446671]
comment: Noc complexes exhibit a dynamic intranuclear location; consider also annotating to 'nucleolus ; GO:0005730' and/or 'nucleoplasm ; GO:0005654'. Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found.
is_a: GO:0030689 ! Noc complex
relationship: part_of GO:0030686 ! 90S preribosome
relationship: part_of GO:0030687 ! preribosome, large subunit precursor

[Term]
id: GO:0030691
name: Noc2p-Noc3p complex
namespace: cellular_component
def: "A heterodimer associated with 66S preribosomes; predominantly nucleoplasmic, but also locates to the nucleolus; involved in ribosomal large subunit biogenesis." [PMID:12446671]
comment: Noc complexes exhibit a dynamic intranuclear location; consider also annotating to 'nucleolus ; GO:0005730' and/or 'nucleoplasm ; GO:0005654'. Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found.
is_a: GO:0030689 ! Noc complex
relationship: part_of GO:0030687 ! preribosome, large subunit precursor

[Term]
id: GO:0030692
name: Noc4p-Nop14p complex
namespace: cellular_component
def: "A heterodimer associated with precursors of the eukaryotic small ribosomal subunit, including the 90S preribosome; involved in small subunit biogenesis." [PMID:12446671]
comment: Noc complexes exhibit a dynamic intranuclear location; consider also annotating to 'nucleolus ; GO:0005730' and/or 'nucleoplasm ; GO:0005654' and/or 'nuclear pore ; GO:0005643'. Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found.
synonym: "Nop7 complex" EXACT [GOC:jh, GOC:mah]
synonym: "Nop7 subcomplex" EXACT [GOC:jh, GOC:mah, PMID:18448671]
is_a: GO:0030689 ! Noc complex
relationship: part_of GO:0030686 ! 90S preribosome
relationship: part_of GO:0030688 ! preribosome, small subunit precursor

[Term]
id: GO:0030693
name: obsolete caspase activity
namespace: molecular_function
alt_id: GO:0004199
def: "OBSOLETE. Catalysis of the hydrolysis of a peptide bond on the carboxyl side of an aspartate residue." [PMID:10872455]
comment: This term was made obsolete because it represents a gene product.
synonym: "caspase activity" EXACT []
synonym: "caspase-1 activity" NARROW []
synonym: "caspase-10 activity" NARROW []
synonym: "caspase-2 activity" NARROW []
synonym: "caspase-3 activity" NARROW []
synonym: "caspase-4 activity" NARROW []
synonym: "caspase-5 activity" NARROW []
synonym: "caspase-6 activity" NARROW []
synonym: "caspase-7 activity" NARROW []
synonym: "caspase-8 activity" NARROW []
synonym: "caspase-9 activity" NARROW []
synonym: "effector caspase activity" NARROW []
synonym: "signaling (initiator) caspase activity" NARROW []
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0030694
name: bacterial-type flagellum basal body, rod
namespace: cellular_component
def: "The central portion of the flagellar basal body, which spans the periplasm and threads through the rings. Examples of this component are found in Bacterial species." [GOC:mtg_sensu, PMID:10572114, PMID:11133968, PMID:12624192]
subset: gosubset_prok
synonym: "flagellar basal body, rod" EXACT []
synonym: "flagellin-based flagellum basal body, rod" EXACT []
is_a: GO:0044461 ! bacterial-type flagellum part
relationship: part_of GO:0009425 ! bacterial-type flagellum basal body

[Term]
id: GO:0030695
name: GTPase regulator activity
namespace: molecular_function
alt_id: GO:0005083
def: "Modulates the rate of GTP hydrolysis by a GTPase." [GOC:mah]
subset: gosubset_prok
synonym: "small GTPase regulator activity" RELATED []
synonym: "small GTPase regulatory/interacting protein activity" RELATED []
is_a: GO:0060589 ! nucleoside-triphosphatase regulator activity
relationship: regulates GO:0003924 ! GTPase activity

[Term]
id: GO:0030696
name: tRNA (m5U54) methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from a donor to the C5 atom of the uridine residue at position 54 in a tRNA molecule." [ISBN:1555811337]
comment: Note that the term name mentions a specific position within a tRNA because no other names have yet arisen for this activity, and because the position is conserved in nearly all tRNAs. The term nevertheless can be used for activities that methylase an analogous residue at a position other than 54, if such is found, and synonyms that mention positions applicable to other tRNAs or species may also be added.
synonym: "RUMT" EXACT []
is_a: GO:0016300 ! tRNA (uracil) methyltransferase activity

[Term]
id: GO:0030697
name: S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity
namespace: molecular_function
alt_id: GO:0009021
def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing thymine at position U54 of a transfer RNA. This occurs in most Gram-negative bacteria, some archae, and eukaryotes." [GOC:hjd, ISBN:1555811337]
synonym: "M5U-methyltransferase activity" EXACT [EC:2.1.1.35]
synonym: "ribothymidyl synthase activity" BROAD [EC:2.1.1.35]
synonym: "RUMT" BROAD []
synonym: "RUMT activity" EXACT [EC:2.1.1.35]
synonym: "S-adenosyl methionine-dependent tRNA (m5U54) methyltransferase activity" EXACT []
synonym: "S-adenosyl-L-methionine:tRNA (uracil-5-)-methyltransferase activity" EXACT [EC:2.1.1.35]
synonym: "transfer RNA uracil 5-methyltransferase activity" EXACT [EC:2.1.1.35]
synonym: "transfer RNA uracil methylase activity" EXACT [EC:2.1.1.35]
synonym: "tRNA (uracil-5-)-methyltransferase activity" EXACT []
synonym: "tRNA uracil 5-methyltransferase activity" EXACT [EC:2.1.1.35]
synonym: "tRNA:m(5)U54-methyltransferase activity" EXACT [EC:2.1.1.35]
synonym: "tRNA:m5U54-methyltransferase activity" EXACT [EC:2.1.1.35]
xref: EC:2.1.1.35
xref: MetaCyc:TRNA-URACIL-5--METHYLTRANSFERASE-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
is_a: GO:0030696 ! tRNA (m5U54) methyltransferase activity

[Term]
id: GO:0030698
name: 5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from 5,10-methylenetetrahydrofolate to the C5 atom of the uridine residue at position 54 in a tRNA molecule. This occurs in most Gram-positive bacteria and some Gram-negative bacteria." [GOC:hjd, ISBN:1555811337]
synonym: "RUMT" BROAD []
is_a: GO:0030696 ! tRNA (m5U54) methyltransferase activity
is_a: GO:0042083 ! 5,10-methylenetetrahydrofolate-dependent methyltransferase activity

[Term]
id: GO:0030699
name: glycine reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl phosphate + H(2)O + NH(4)(+) + thioredoxin disulfide = glycine + H(+) + phosphate + thioredoxin." [EC:1.21.4.2, RHEA:12235]
subset: gosubset_prok
synonym: "acetyl-phosphate ammonia:thioredoxin disulfide oxidoreductase (glycine-forming)" EXACT [EC:1.21.4.2]
xref: EC:1.21.4.2
xref: KEGG:R07226
xref: MetaCyc:RXN-7566
xref: RHEA:12235
is_a: GO:0050485 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor

[Term]
id: GO:0030700
name: glycine reductase complex
namespace: cellular_component
def: "Complex that possesses glycine reductase activity; usually comprises three subunits, of which two are selenoproteins; the subunits are typically designated selenoprotein A, selenoprotein B and protein C." [GOC:mah, PMID:2018775]
comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'glycine reductase activity ; GO:0030699'.
subset: gosubset_prok
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:0030701
name: NAD+-dinitrogen-reductase ADP-D-ribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + [dinitrogen reductase] = nicotinamide + ADP-D-ribosyl-[dinitrogen reductase]." [EC:2.4.2.37]
subset: gosubset_prok
synonym: "ADP-ribosyltransferase activity" BROAD [EC:2.4.2.37]
synonym: "NAD+:[dinitrogen reductase] (ADP-D-ribosyl)transferase activity" EXACT [EC:2.4.2.37]
synonym: "NAD--azoferredoxin (ADP-ribose)transferase activity" EXACT [EC:2.4.2.37]
synonym: "NAD-azoferredoxin (ADPribose)transferase activity" EXACT [EC:2.4.2.37]
synonym: "NAD-dinitrogen-reductase ADP-D-ribosyltransferase activity" EXACT []
xref: EC:2.4.2.37
xref: MetaCyc:2.4.2.37-RXN
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0030702
name: chromatin silencing at centromere
namespace: biological_process
def: "Repression of transcription of centromeric DNA by altering the structure of chromatin." [GOC:mah]
synonym: "centromere chromatin silencing" EXACT [GOC:mah]
synonym: "centromeric silencing" EXACT [GOC:vw]
synonym: "heterochromatic silencing at centromere" EXACT []
is_a: GO:0006342 ! chromatin silencing
intersection_of: GO:0006342 ! chromatin silencing
intersection_of: occurs_in GO:0000775 ! chromosome, centromeric region
relationship: occurs_in GO:0000775 ! chromosome, centromeric region

[Term]
id: GO:0030703
name: eggshell formation
namespace: biological_process
def: "Construction of the eggshell, a product of the somatic follicle cell epithelium and a structure that supports the egg in a hostile environment, minimizing water loss whilst allowing gas exchanges essential for embryonic respiration." [GOC:mtg_sensu, ISBN:0879694238, PMID:10822261]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0048477 ! oogenesis

[Term]
id: GO:0030704
name: vitelline membrane formation
namespace: biological_process
def: "Construction of the vitelline membrane portion of the egg shell, a rigid structure required to maintain the shape of the egg." [ISBN:0879694238]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
is_a: GO:0035803 ! egg coat formation
is_a: GO:0085029 ! extracellular matrix assembly

[Term]
id: GO:0030705
name: cytoskeleton-dependent intracellular transport
namespace: biological_process
def: "The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell." [GOC:mah]
subset: goslim_chembl
subset: goslim_generic
subset: gosubset_prok
is_a: GO:1902582 ! single-organism intracellular transport

[Term]
id: GO:0030706
name: germarium-derived oocyte differentiation
namespace: biological_process
def: "The process in which one relatively unspecialized immature cystocyte of the germ-line cyst in the germarium acquires the specialized features of an oocyte. An example of this process can be found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
synonym: "oocyte cell differentiation" RELATED []
is_a: GO:0009994 ! oocyte differentiation
relationship: part_of GO:0007293 ! germarium-derived egg chamber formation

[Term]
id: GO:0030707
name: ovarian follicle cell development
namespace: biological_process
def: "The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
is_a: GO:0002066 ! columnar/cuboidal epithelial cell development
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
relationship: part_of GO:0048477 ! oogenesis

[Term]
id: GO:0030708
name: germarium-derived female germ-line cyst encapsulation
namespace: biological_process
def: "Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the germarium. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11591336]
is_a: GO:0048139 ! female germ-line cyst encapsulation
relationship: part_of GO:0007293 ! germarium-derived egg chamber formation
relationship: part_of GO:0030707 ! ovarian follicle cell development

[Term]
id: GO:0030709
name: border follicle cell delamination
namespace: biological_process
def: "The delamination process that results in the splitting off of border cells from the anterior epithelium, prior to border cell migration." [PMID:10822261]
synonym: "border cell delamination" BROAD []
is_a: GO:0022414 ! reproductive process
is_a: GO:0060232 ! delamination
relationship: part_of GO:0030707 ! ovarian follicle cell development

[Term]
id: GO:0030710
name: regulation of border follicle cell delamination
namespace: biological_process
def: "Any process that regulates the frequency, rate or extent of border cell delamination." [PMID:10822261]
synonym: "regulation of border cell delamination" BROAD []
is_a: GO:0022407 ! regulation of cell-cell adhesion
is_a: GO:0030856 ! regulation of epithelial cell differentiation
is_a: GO:0043900 ! regulation of multi-organism process
is_a: GO:0060284 ! regulation of cell development
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030709 ! border follicle cell delamination
relationship: regulates GO:0030709 ! border follicle cell delamination

[Term]
id: GO:0030711
name: positive regulation of border follicle cell delamination
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of border cell delamination." [PMID:10822261]
synonym: "activation of border follicle cell delamination" NARROW []
synonym: "positive regulation of border cell delamination" BROAD []
synonym: "stimulation of border follicle cell delamination" NARROW []
synonym: "up regulation of border follicle cell delamination" EXACT []
synonym: "up-regulation of border follicle cell delamination" EXACT []
synonym: "upregulation of border follicle cell delamination" EXACT []
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0030710 ! regulation of border follicle cell delamination
is_a: GO:0030858 ! positive regulation of epithelial cell differentiation
is_a: GO:0043902 ! positive regulation of multi-organism process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000243 ! positive regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030709 ! border follicle cell delamination
relationship: positively_regulates GO:0030709 ! border follicle cell delamination

[Term]
id: GO:0030712
name: negative regulation of border follicle cell delamination
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of border cell delamination." [PMID:10822261]
synonym: "down regulation of border follicle cell delamination" EXACT []
synonym: "down-regulation of border follicle cell delamination" EXACT []
synonym: "downregulation of border follicle cell delamination" EXACT []
synonym: "inhibition of border follicle cell delamination" NARROW []
synonym: "negative regulation of border cell delamination" BROAD []
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0022409 ! positive regulation of cell-cell adhesion
is_a: GO:0030710 ! regulation of border follicle cell delamination
is_a: GO:0030857 ! negative regulation of epithelial cell differentiation
is_a: GO:0043901 ! negative regulation of multi-organism process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000242 ! negative regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030709 ! border follicle cell delamination
relationship: negatively_regulates GO:0030709 ! border follicle cell delamination

[Term]
id: GO:0030713
name: ovarian follicle cell stalk formation
namespace: biological_process
def: "Development of ovarian follicle cells to create the interfollicular stalks that connect the egg chambers of progressive developmental stages. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
is_a: GO:0000904 ! cell morphogenesis involved in differentiation
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
relationship: part_of GO:0030707 ! ovarian follicle cell development

[Term]
id: GO:0030714
name: anterior/posterior axis specification, follicular epithelium
namespace: biological_process
def: "Polarization of the follicle cells of an insect ovary along the anterior/posterior axis." [GOC:bf]
synonym: "anterior/posterior axis determination, follicular epithelium" EXACT [GOC:dph, GOC:tb]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0009798 ! axis specification
is_a: GO:0016334 ! establishment or maintenance of polarity of follicular epithelium
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
relationship: part_of GO:0030707 ! ovarian follicle cell development

[Term]
id: GO:0030715
name: oocyte growth in germarium-derived egg chamber
namespace: biological_process
def: "The increase in volume of an oocyte during the growth phase of the egg chamber, once the egg chamber has left the germarium. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
is_a: GO:0001555 ! oocyte growth
relationship: part_of GO:0007295 ! growth of a germarium-derived egg chamber

[Term]
id: GO:0030716
name: oocyte fate determination
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators]
synonym: "oocyte cell fate determination" EXACT []
is_a: GO:0001709 ! cell fate determination

[Term]
id: GO:0030717
name: karyosome formation
namespace: biological_process
def: "The chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome." [PMID:11700288, PMID:18039935]
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0051276 ! chromosome organization
is_a: GO:1902589 ! single-organism organelle organization
relationship: part_of GO:0048477 ! oogenesis

[Term]
id: GO:0030718
name: germ-line stem cell population maintenance
namespace: biological_process
def: "Any process by which an organism or tissue maintains a population of germ-line stem cells." [ISBN:0879694238]
is_a: GO:0019827 ! stem cell population maintenance

[Term]
id: GO:0030719
name: P granule organization
namespace: biological_process
alt_id: GO:0048114
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of polar granules, cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes." [PMID:10851135, PMID:770367]
synonym: "P granule organization and biogenesis" RELATED []
synonym: "polar granule organisation" EXACT [GOC:curators]
synonym: "polar granule organization and biogenesis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0071826 ! ribonucleoprotein complex subunit organization
is_a: GO:1902589 ! single-organism organelle organization
relationship: part_of GO:0007315 ! pole plasm assembly

[Term]
id: GO:0030720
name: oocyte localization involved in germarium-derived egg chamber formation
namespace: biological_process
def: "Directed movement of the oocyte, following its specification, from its original central position in the cyst to a posterior position relative to the nurse cells of the egg chamber, and its maintenance in this posterior location. This is the first sign of anterior-posterior asymmetry in the developing egg chamber." [GOC:mtg_sensu, PMID:10449356]
synonym: "establishment and maintenance of oocyte localization in egg chamber" EXACT []
synonym: "establishment and maintenance of oocyte position during oogenesis" EXACT []
synonym: "oocyte localisation involved in germarium-derived egg chamber formation" EXACT [GOC:mah]
synonym: "oocyte localization during germarium-derived egg chamber formation" RELATED [GOC:dph, GOC:tb]
synonym: "oocyte localization during oogenesis" RELATED []
synonym: "oocyte positioning during oogenesis" NARROW []
synonym: "oogenesis, establishment and maintenance of oocyte localization" EXACT []
synonym: "oogenesis, oocyte localization" EXACT []
is_a: GO:0022414 ! reproductive process
is_a: GO:0051674 ! localization of cell
relationship: part_of GO:0007293 ! germarium-derived egg chamber formation

[Term]
id: GO:0030721
name: spectrosome organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spectrosome, a germline specific spherical organelle that is the precursor to the fusome." [PMID:11131529]
synonym: "spectrosome organisation" EXACT [GOC:curators]
synonym: "spectrosome organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0030722
name: establishment of oocyte nucleus localization involved in oocyte dorsal/ventral axis specification
namespace: biological_process
alt_id: GO:0048126
def: "The directed movement of the nucleus to a specific location within the cell during the establishment and maintenance of the dorsal/ventral axis of the oocyte. In the insect oocyte, for example, the nucleus is repositioned to a dorso-anterior position." [GOC:dph, GOC:mah, GOC:mtg_sensu, GOC:tb]
synonym: "establishment of localization of oocyte nucleus during oocyte axis determination" BROAD []
synonym: "establishment of oocyte nucleus localisation involved in oocyte dorsal/ventral axis specification" EXACT [GOC:mah]
synonym: "establishment of oocyte nucleus localization during oocyte axis determination" BROAD [GOC:dph, GOC:tb]
synonym: "establishment of oocyte nucleus localization involved in oocyte dorsal-ventral axis specification" EXACT [GOC:mah]
synonym: "establishment of oocyte nucleus localization involved in oocyte dorsal/ventral axis determination" EXACT [GOC:dph, GOC:tb]
synonym: "establishment of oocyte nucleus localization involved in oocyte dorsoventral axis specification" EXACT [GOC:mah]
synonym: "nucleus positioning in oocyte during oocyte axis determination" BROAD []
synonym: "oocyte axis determination, establishment of localization of nucleus" BROAD []
synonym: "oocyte axis determination, establishment of oocyte nucleus localization" BROAD []
synonym: "oocyte axis determination, establishment of position of nucleus" BROAD []
synonym: "oocyte axis determination, positioning of nucleus" BROAD []
synonym: "oocyte nucleus positioning during oocyte axis determination" BROAD []
is_a: GO:0022414 ! reproductive process
is_a: GO:0040023 ! establishment of nucleus localization
intersection_of: GO:0040023 ! establishment of nucleus localization
intersection_of: part_of GO:0007309 ! oocyte axis specification
relationship: part_of GO:0007309 ! oocyte axis specification
relationship: part_of GO:0051663 ! oocyte nucleus localization involved in oocyte dorsal/ventral axis specification

[Term]
id: GO:0030723
name: ovarian fusome organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome of ovarian cells, an organelle derived from the spectrosome. It anchors the mitotic spindle pole to provide orientation during cystoblast cell divisions." [GOC:dph, GOC:jl, GOC:mah, ISBN:0879694238]
synonym: "ovarian fusome organisation" EXACT [GOC:curators]
synonym: "ovarian fusome organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0045478 ! fusome organization
is_a: GO:1902589 ! single-organism organelle organization
relationship: part_of GO:0007293 ! germarium-derived egg chamber formation

[Term]
id: GO:0030724
name: testicular fusome organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome of testicular cells, an organelle derived from the spectrosome." [GOC:dph, GOC:jl, GOC:mah, ISBN:0879694238]
synonym: "testicular fusome organisation" EXACT [GOC:curators]
synonym: "testicular fusome organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0045478 ! fusome organization
is_a: GO:1902589 ! single-organism organelle organization
relationship: part_of GO:0007283 ! spermatogenesis

[Term]
id: GO:0030725
name: germline ring canal formation
namespace: biological_process
def: "Assembly of the cytoplasmic bridges between developing spermatogonial or oogonial cysts." [ISBN:0879694238]
synonym: "ring canal formation" BROAD []
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0043063 ! intercellular bridge organization
relationship: part_of GO:0032504 ! multicellular organism reproduction

[Term]
id: GO:0030726
name: male germline ring canal formation
namespace: biological_process
def: "Formation of the intercellular bridges that connect the germ-line cells of a male cyst." [ISBN:0879694238]
synonym: "spermatocyte ring canal formation" NARROW []
synonym: "testicular ring canal formation" NARROW []
is_a: GO:0030725 ! germline ring canal formation
relationship: part_of GO:0007283 ! spermatogenesis

[Term]
id: GO:0030727
name: germarium-derived female germ-line cyst formation
namespace: biological_process
def: "Formation, in a germarium, of a group of interconnected cells derived from a single female gonial founder cell (a cystoblast). The germarium is the most anterior portion of an insect ovariole. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10370240, PMID:9442902]
synonym: "germarium-derived female germline cyst formation" EXACT []
is_a: GO:0048135 ! female germ-line cyst formation
relationship: part_of GO:0007293 ! germarium-derived egg chamber formation

[Term]
id: GO:0030728
name: ovulation
namespace: biological_process
def: "The release of a mature ovum/oocyte from an ovary." [GOC:bf, ISBN:0878932437]
xref: Wikipedia:Ovulation
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0048609 ! multicellular organismal reproductive process
relationship: part_of GO:0007292 ! female gamete generation

[Term]
id: GO:0030729
name: acetoacetate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate + H(+)." [EC:6.2.1.16, RHEA:16120]
subset: gosubset_prok
synonym: "acetoacetate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.16]
synonym: "acetoacetyl-CoA synthetase activity" EXACT []
xref: EC:6.2.1.16
xref: KEGG:R01357
xref: MetaCyc:ACETOACETATE--COA-LIGASE-RXN
xref: RHEA:16120
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0030730
name: sequestering of triglyceride
namespace: biological_process
def: "The process of binding or confining any triester of glycerol such that it is separated from other components of a biological system." [GOC:mah, ISBN:0198506732]
synonym: "retention of triacylglycerol" EXACT []
synonym: "retention of triglyceride" EXACT []
synonym: "sequestering of triacylglycerol" EXACT []
synonym: "sequestration of triacylglycerol" EXACT []
synonym: "sequestration of triglyceride" EXACT []
synonym: "storage of triacylglycerol" EXACT []
synonym: "storage of triglyceride" EXACT []
synonym: "triacylglycerol retention" EXACT []
synonym: "triacylglycerol sequestering" EXACT []
synonym: "triacylglycerol sequestration" EXACT []
synonym: "triacylglycerol storage" EXACT []
synonym: "triglyceride retention" EXACT []
synonym: "triglyceride sequestering" EXACT []
synonym: "triglyceride sequestration" EXACT []
synonym: "triglyceride storage" EXACT []
is_a: GO:0019915 ! lipid storage

[Term]
id: GO:0030731
name: guanidinoacetate N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanidinoacetate = S-adenosyl-L-homocysteine + creatine + H(+)." [EC:2.1.1.2, RHEA:10659]
synonym: "GA methylpherase activity" EXACT [EC:2.1.1.2]
synonym: "guanidinoacetate methyltransferase activity" EXACT [EC:2.1.1.2]
synonym: "guanidinoacetate transmethylase activity" EXACT [EC:2.1.1.2]
synonym: "guanidoacetate methyltransferase activity" EXACT [EC:2.1.1.2]
synonym: "methionine-guanidinoacetic transmethylase activity" EXACT [EC:2.1.1.2]
synonym: "S-adenosyl-L-methionine:N-guanidinoacetate methyltransferase activity" EXACT [EC:2.1.1.2]
xref: EC:2.1.1.2
xref: KEGG:R01883
xref: MetaCyc:GUANIDINOACETATE-N-METHYLTRANSFERASE-RXN
xref: RHEA:10659
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030732
name: methionine S-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + L-methionine = S-adenosyl-L-homocysteine + S-methyl-L-methionine." [EC:2.1.1.12]
synonym: "methionine methyltransferase activity" EXACT [EC:2.1.1.12]
synonym: "S-adenosyl methionine:methionine methyl transferase activity" EXACT [EC:2.1.1.12]
synonym: "S-adenosyl-L-methionine:L-methionine S-methyltransferase activity" EXACT [EC:2.1.1.12]
synonym: "S-adenosylmethionine transmethylase activity" EXACT [EC:2.1.1.12]
synonym: "S-adenosylmethionine-methionine methyltransferase activity" EXACT [EC:2.1.1.12]
xref: EC:2.1.1.12
xref: MetaCyc:METHIONINE-S-METHYLTRANSFERASE-RXN
xref: RHEA:13764
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030733
name: fatty acid O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + a fatty acid = S-adenosyl-L-homocysteine + a fatty acid methyl ester." [EC:2.1.1.15]
synonym: "fatty acid methyltransferase activity" EXACT [EC:2.1.1.15]
synonym: "fatty-acid O-methyltransferase activity" EXACT []
synonym: "S-adenosyl-L-methionine:fatty-acid O-methyltransferase activity" EXACT [EC:2.1.1.15]
xref: EC:2.1.1.15
xref: MetaCyc:FATTY-ACID-O-METHYLTRANSFERASE-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030734
name: polysaccharide O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 1,4-N1-D-glucooligosaccharide = S-adenosyl-L-homocysteine + oligosaccharide containing 6-methyl-D-glucose units." [EC:2.1.1.18]
synonym: "acylpolysacharide 6-methyltransferase activity" EXACT [EC:2.1.1.18]
synonym: "polysaccharide methyltransferase activity" EXACT [EC:2.1.1.18]
synonym: "S-adenosyl-L-methionine:1,4-alpha-D-glucan 6-O-methyltransferase activity" EXACT [EC:2.1.1.18]
xref: EC:2.1.1.18
xref: MetaCyc:POLYSACCHARIDE-O-METHYLTRANSFERASE-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030735
name: carnosine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + carnosine = S-adenosyl-L-homocysteine + anserine + H(+)." [EC:2.1.1.22, RHEA:14208]
synonym: "S-adenosyl-L-methionine:carnosine N-methyltransferase activity" EXACT [EC:2.1.1.22]
xref: EC:2.1.1.22
xref: KEGG:R02144
xref: MetaCyc:CARNOSINE-N-METHYLTRANSFERASE-RXN
xref: RHEA:14208
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030736
name: phenol O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + phenol = S-adenosyl-L-homocysteine + anisole + H(+)." [EC:2.1.1.25, RHEA:14812]
synonym: "PMT" RELATED [EC:2.1.1.25]
synonym: "S-adenosyl-L-methionine:phenol O-methyltransferase activity" EXACT [EC:2.1.1.25]
xref: EC:2.1.1.25
xref: KEGG:R01239
xref: MetaCyc:PHENOL-O-METHYLTRANSFERASE-RXN
xref: RHEA:14812
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030737
name: iodophenol O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-iodophenol + S-adenosyl-L-methionine = 1-iodo-2-methoxybenzene + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.26, RHEA:14316]
synonym: "S-adenosyl-L-methionine:2-iodophenol O-methyltransferase activity" EXACT [EC:2.1.1.26]
xref: EC:2.1.1.26
xref: KEGG:R03746
xref: MetaCyc:IODOPHENOL-O-METHYLTRANSFERASE-RXN
xref: RHEA:14316
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030738
name: tyramine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + tyramine = N-methyltyramine + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.27, RHEA:14868]
synonym: "DIB O-methyltransferase (3,5-diiodo-4-hydroxy-benzoic acid)" EXACT [EC:2.1.1.27]
synonym: "S-adenosyl-L-methionine:tyramine N-methyltransferase activity" EXACT [EC:2.1.1.27]
synonym: "S-adenosyl-methionine:tyramine N-methyltransferase activity" EXACT [EC:2.1.1.27]
synonym: "tyramine methylpherase activity" EXACT [EC:2.1.1.27]
xref: EC:2.1.1.27
xref: KEGG:R02384
xref: MetaCyc:TYRAMINE-N-METHYLTRANSFERASE-RXN
xref: RHEA:14868
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030739
name: O-demethylpuromycin O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + O-demethylpuromycin = S-adenosyl-L-homocysteine + puromycin." [EC:2.1.1.38]
subset: gosubset_prok
synonym: "O-demethylpuromycin methyltransferase activity" EXACT [EC:2.1.1.38]
synonym: "S-adenosyl-L-methionine:O-demethylpuromycin O-methyltransferase activity" EXACT [EC:2.1.1.38]
xref: EC:2.1.1.38
xref: MetaCyc:2.1.1.38-RXN
xref: RHEA:22283
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030740
name: inositol 3-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + myo-inositol = 1D-3-O-methyl-myo-inositol + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.39, RHEA:18880]
synonym: "inositol L-1-methyltransferase activity" EXACT [EC:2.1.1.39]
synonym: "myo-inositol 1-methyltransferase activity" RELATED [EC:2.1.1.39]
synonym: "myo-inositol 1-O-methyltransferase (name based on 1L-numbering system and not 1D-numbering)" EXACT [EC:2.1.1.39]
synonym: "myo-inositol 1-O-methyltransferase activity" RELATED [EC:2.1.1.39]
synonym: "S-adenosyl-L-methionine:1D-myo-inositol 3-O-methyltransferase activity" EXACT [EC:2.1.1.39]
synonym: "S-adenosyl-L-methionine:myo-inositol 1-O-methyltransferase activity" EXACT [EC:2.1.1.39]
synonym: "S-adenosylmethionine:myo-inositol 1-methyltransferase activity" EXACT [EC:2.1.1.39]
xref: EC:2.1.1.39
xref: KEGG:R01189
xref: MetaCyc:MYO-INOSITOL-1-O-METHYLTRANSFERASE-RXN
xref: RHEA:18880
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030741
name: inositol 1-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + myo-inositol = 1D-1-O-methyl-myo-inositol + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.40, RHEA:17568]
synonym: "inositol 3-O-methyltransferase (name based on 1L-numbering system and not 1D-numbering)" EXACT [EC:2.1.1.40]
synonym: "inositol 3-O-methyltransferase activity" RELATED [EC:2.1.1.40]
synonym: "inositol D-1-methyltransferase activity" EXACT [EC:2.1.1.40]
synonym: "myo-inositol 3-O-methyltransferase activity" RELATED [EC:2.1.1.40]
synonym: "S-adenosyl-L-methionine:1D-myo-inositol 1-O-methyltransferase activity" EXACT [EC:2.1.1.40]
synonym: "S-adenosyl-L-methionine:myo-inositol 3-O-methyltransferase activity" EXACT [EC:2.1.1.40]
synonym: "S-adenosylmethionine:myo-inositol 3-methyltransferase activity" RELATED [EC:2.1.1.40]
xref: EC:2.1.1.40
xref: KEGG:R01188
xref: MetaCyc:MYO-INOSITOL-3-O-METHYLTRANSFERASE-RXN
xref: RHEA:17568
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030742
name: GTP-dependent protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) using energy from the hydrolysis of GTP." [GOC:go_curators]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0030743
name: rRNA (adenosine-2'-O-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing a single residue of 2'-O-methyladenosine." [EC:2.1.1.66]
subset: gosubset_prok
synonym: "ribosomal ribonucleate adenosine 2'-methyltransferase activity" EXACT [EC:2.1.1.66]
synonym: "RNA-pentose methylase activity" RELATED [EC:2.1.1.66]
synonym: "rRNA adenosine 2'-methylase activity" EXACT [EC:2.1.1.66]
synonym: "S-adenosyl-L-methionine:rRNA (adenosine-2'-O)-methyltransferase activity" EXACT [EC:2.1.1.66]
synonym: "thiostrepton-resistance methylase activity" NARROW [EC:2.1.1.66]
xref: EC:2.1.1.66
xref: MetaCyc:2.1.1.66-RXN
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0016433 ! rRNA (adenine) methyltransferase activity

[Term]
id: GO:0030744
name: luteolin O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + luteolin = 4',5,7-trihydroxy-3'-methoxyflavone + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.42, RHEA:14592]
synonym: "luteolin 3'-O-methyltransferase activity" EXACT [EC:2.1.1.42]
synonym: "luteolin methyltransferase activity" EXACT [EC:2.1.1.42]
synonym: "o-dihydric phenol meta-O-methyltransferase activity" EXACT [EC:2.1.1.42]
synonym: "o-dihydric phenol methyltransferase activity" EXACT [EC:2.1.1.42]
synonym: "o-diphenol m-O-methyltransferase activity" EXACT [EC:2.1.1.42]
synonym: "S-adenosyl-L-methionine:5,7,3',4'-tetrahydroxyflavone 3'-O-methyltransferase activity" EXACT [EC:2.1.1.42]
synonym: "S-adenosylmethionine:flavone/flavonol 3'-O-methyltransferase activity" EXACT [EC:2.1.1.42]
xref: EC:2.1.1.42
xref: KEGG:R03587
xref: MetaCyc:LUTEOLIN-O-METHYLTRANSFERASE-RXN
xref: RHEA:14592
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030745
name: dimethylhistidine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + N-alpha,N-alpha-dimethyl-L-histidine = S-adenosyl-L-homocysteine + N-alpha,N-alpha,N-alpha-trimethyl-L-histidine." [EC:2.1.1.44]
synonym: "dimethylhistidine methyltransferase activity" EXACT [EC:2.1.1.44]
synonym: "histidine-alpha-N-methyltransferase activity" BROAD [EC:2.1.1.44]
synonym: "S-adenosyl-L-methionine:alpha-N,alpha-N-dimethyl-L-histidine alpha-N-methyltransferase activity" EXACT [EC:2.1.1.44]
synonym: "S-adenosyl-L-methionine:Nalpha,Nalpha-dimethyl-L-histidine nalpha-methyltransferase activity" EXACT [EC:2.1.1.44]
xref: EC:2.1.1.44
xref: KEGG:R04436
xref: MetaCyc:2.1.1.44-RXN
xref: RHEA:11107
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030746
name: isoflavone 4'-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + isoflavone = S-adenosyl-L-homocysteine + 4'-O-methylisoflavone." [EC:2.1.1.46]
synonym: "4'-hydroxyisoflavone methyltransferase activity" EXACT [EC:2.1.1.46]
synonym: "isoflavone methyltransferase activity" EXACT [EC:2.1.1.46]
synonym: "isoflavone O-methyltransferase activity" EXACT [EC:2.1.1.46]
synonym: "S-adenosyl-L-methionine:isoflavone 4'-O-methyltransferase activity" EXACT [EC:2.1.1.46]
xref: EC:2.1.1.46
xref: MetaCyc:ISOFLAVONE-4-O-METHYLTRANSFERASE-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030747
name: indolepyruvate C-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + (indol-3-yl)pyruvate = S-adenosyl-L-homocysteine + (S)-3-(indol-3-yl)-2-oxobutanoate." [EC:2.1.1.47]
synonym: "indolepyruvate 3-methyltransferase activity" EXACT [EC:2.1.1.47]
synonym: "indolepyruvate methyltransferase activity" EXACT [EC:2.1.1.47]
synonym: "indolepyruvic acid methyltransferase activity" EXACT [EC:2.1.1.47]
synonym: "S-adenosyl-L-methionine:(indol-3-yl)pyruvate C-methyltransferase activity" EXACT [EC:2.1.1.47]
synonym: "S-adenosyl-L-methionine:indolepyruvate C-methyltransferase activity" EXACT [EC:2.1.1.47]
xref: EC:2.1.1.47
xref: MetaCyc:INDOLEPYRUVATE-C-METHYLTRANSFERASE-RXN
xref: RHEA:12115
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030748
name: amine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine." [EC:2.1.1.49]
synonym: "arylamine N-methyltransferase activity" NARROW [EC:2.1.1.49]
synonym: "nicotine N-methyltransferase activity" NARROW [EC:2.1.1.49]
synonym: "S-adenosyl-L-methionine:amine N-methyltransferase activity" EXACT [EC:2.1.1.49]
synonym: "tryptamine methyltransferase" NARROW [EC:2.1.1.49]
synonym: "tryptamine N-methyltransferase activity" NARROW [EC:2.1.1.49]
xref: EC:2.1.1.49
xref: MetaCyc:AMINE-N-METHYLTRANSFERASE-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030749
name: loganate O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + loganate = S-adenosyl-L-homocysteine + loganin." [EC:2.1.1.50]
synonym: "loganate methyltransferase activity" EXACT [EC:2.1.1.50]
synonym: "S-adenosyl-L-methionine:loganate 11-O-methyltransferase activity" EXACT [EC:2.1.1.50]
synonym: "S-adenosyl-L-methionine:loganic acid methyltransferase activity" EXACT [EC:2.1.1.50]
xref: EC:2.1.1.50
xref: MetaCyc:LOGANATE-O-METHYLTRANSFERASE-RXN
xref: RHEA:12511
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030750
name: putrescine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + putrescine = N-methylputrescine + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.53, RHEA:15040]
synonym: "putrescine methyltransferase activity" EXACT [EC:2.1.1.53]
synonym: "S-adenosyl-L-methionine:putrescine N-methyltransferase activity" EXACT [EC:2.1.1.53]
xref: EC:2.1.1.53
xref: KEGG:R01153
xref: MetaCyc:PUTRESCINE-N-METHYLTRANSFERASE-RXN
xref: RHEA:15040
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030751
name: licodione 2'-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + licodione = 2'-O-methyllicodione + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.65, RHEA:18524]
synonym: "S-adenosyl-L-methionine:licodione 2'-O-methyltransferase activity" EXACT [EC:2.1.1.65]
xref: EC:2.1.1.65
xref: KEGG:R03623
xref: MetaCyc:LICODIONE-2-O-METHYLTRANSFERASE-RXN
xref: RHEA:18524
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030752
name: 5-hydroxyfuranocoumarin 5-O-methyltransferase activity
namespace: molecular_function
alt_id: GO:0030764
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 5-hydroxyfuranocoumarin = S-adenosyl-L-homocysteine + 5-methoxyfuranocoumarin." [EC:2.1.1.69]
synonym: "bergaptol 5-O-methyltransferase activity" EXACT [EC:2.1.1.69]
synonym: "bergaptol methyltransferase activity" EXACT [EC:2.1.1.69]
synonym: "bergaptol O-methyltransferase activity" EXACT [EC:2.1.1.69]
synonym: "BMT activity" EXACT [EC:2.1.1.69]
synonym: "furanocoumarin 5-methyltransferase activity" EXACT [EC:2.1.1.69]
synonym: "furanocoumarin 5-O-methyltransferase activity" EXACT [EC:2.1.1.69]
synonym: "S-adenosyl-L-methionine:5-hydroxyfuranocoumarin 5-O-methyltransferase activity" EXACT [EC:2.1.1.69]
synonym: "S-adenosyl-L-methionine:5-hydroxyfurocoumarin 5-O-methyltransferase activity" EXACT [EC:2.1.1.69]
synonym: "S-adenosyl-L-methionine:bergaptol O-methyltransferase activity" EXACT [EC:2.1.1.69]
synonym: "S-adenosyl-L-methionine:bergaptolO-methyltransferase activity" EXACT [EC:2.1.1.69]
xref: EC:2.1.1.69
xref: MetaCyc:2.1.1.69-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030753
name: 8-hydroxyfuranocoumarin 8-O-methyltransferase activity
namespace: molecular_function
alt_id: GO:0030765
def: "Catalysis of the reaction: S-adenosyl-L-methionine + xanthotoxol = S-adenosyl-L-homocysteine + xanthotoxin. Xanthotoxol is also known as 8-hydroxyfuranocoumarin and xanthotoxin as 8-methoxyfuranocoumarin." [EC:2.1.1.70]
synonym: "furanocoumarin 8-methyltransferase activity" EXACT [EC:2.1.1.70]
synonym: "furanocoumarin 8-O-methyl-transferase activity" EXACT [EC:2.1.1.70]
synonym: "S-adenosyl-L-methionine:8-hydroxyfuranocoumarin 8-O-methyltransferase activity" EXACT [EC:2.1.1.70]
synonym: "S-adenosyl-L-methionine:8-hydroxyfurocoumarin 8-O-methyltransferase activity" EXACT [EC:2.1.1.70]
synonym: "S-adenosyl-L-methionine:xanthotoxol O-methyltransferase activity" EXACT [EC:2.1.1.70]
synonym: "xanthotoxol 8-O-methyltransferase activity" EXACT [EC:2.1.1.70]
synonym: "xanthotoxol methyltransferase activity" EXACT [EC:2.1.1.70]
synonym: "xanthotoxol O-methyltransferase activity" EXACT []
synonym: "XMT activity" RELATED [EC:2.1.1.70]
xref: EC:2.1.1.70
xref: KEGG:R02982
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030754
name: apigenin 4'-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 5,7,4'-trihydroxyflavone = S-adenosyl-L-homocysteine + 4'-methoxy-5,7-dihydroxyflavone." [EC:2.1.1.75]
synonym: "flavonoid methyltransferase activity" EXACT [EC:2.1.1.75]
synonym: "flavonoid O-methyltransferase activity" BROAD [EC:2.1.1.75]
synonym: "S-adenosyl-L-methionine:5,7,4'-trihydroxyflavone 4'-O-methyltransferase activity" EXACT [EC:2.1.1.75]
xref: EC:2.1.1.75
xref: MetaCyc:APIGENIN-4-O-METHYLTRANSFERASE-RXN
xref: RHEA:20432
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030755
name: quercetin 3-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxy-flavone." [EC:2.1.1.76]
synonym: "flavonoid 3-methyltransferase activity" EXACT [EC:2.1.1.76]
synonym: "flavonol 3-O-methyltransferase activity" RELATED [EC:2.1.1.76]
synonym: "S-adenosyl-L-methionine:3,5,7,3',4'-pentahydroxyflavone 3-O-methyltransferase activity" EXACT [EC:2.1.1.76]
xref: EC:2.1.1.76
xref: MetaCyc:QUERCETIN-3-O-METHYLTRANSFERASE-RXN
xref: RHEA:17676
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030756
name: isoorientin 3'-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + isoorientin = S-adenosyl-L-homocysteine + H(+) + isoscoparin." [EC:2.1.1.78, RHEA:24099]
synonym: "isoorientin 3'-methyltransferase activity" EXACT [EC:2.1.1.78]
synonym: "S-adenosyl-L-methionine:isoorientin 3'-O-methyltransferase activity" EXACT [EC:2.1.1.78]
xref: EC:2.1.1.78
xref: KEGG:R03731
xref: MetaCyc:ISOORIENTIN-3-O-METHYLTRANSFERASE-RXN
xref: RHEA:24099
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030757
name: 3-methylquercitin 7-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine(1+) = 3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-homocysteine." [EC:2.1.1.82, RHEA:16184]
synonym: "3-methylquercetin 7-O-methyltransferase activity" EXACT [EC:2.1.1.82]
synonym: "7-OMT activity" RELATED [EC:2.1.1.82]
synonym: "flavonol 7-methyltransferase activity" RELATED [EC:2.1.1.82]
synonym: "flavonol 7-O-methyltransferase activity" RELATED [EC:2.1.1.82]
synonym: "S-adenosyl-L-methionine:3',4',5,7-tetrahydroxy-3-methoxyflavone 7-O-methyltransferase activity" EXACT [EC:2.1.1.82]
synonym: "S-adenosyl-L-methionine:5,7,3',4'-tetrahydroxy-3-methoxyflavone 7-O-methyltransferase activity" EXACT [EC:2.1.1.82]
xref: EC:2.1.1.82
xref: KEGG:R05323
xref: MetaCyc:2.1.1.82-RXN
xref: RHEA:16184
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030758
name: 3,7-dimethylquercitin 4'-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine(1+) = 3',5-dihydroxy-3,4',7-trimethoxyflavone + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.83, RHEA:21835]
synonym: "3,7-dimethylquercetin 4'-O-methyltransferase activity" EXACT [EC:2.1.1.83]
synonym: "4'-OMT activity" RELATED [EC:2.1.1.83]
synonym: "flavonol 4'-methyltransferase activity" RELATED [EC:2.1.1.83]
synonym: "flavonol 4'-O-methyltransferase activity" RELATED [EC:2.1.1.83]
synonym: "S-adenosyl-L-methionine:3',4',5-trihydroxy-3,7-dimethoxyflavone 4'-O-methyltransferase activity" EXACT [EC:2.1.1.83]
synonym: "S-adenosyl-L-methionine:5,3',4'-trihydroxy-3,7-dimethoxyflavone 4'-O-methyltransferase activity" EXACT [EC:2.1.1.83]
xref: EC:2.1.1.83
xref: KEGG:R03456
xref: MetaCyc:2.1.1.83-RXN
xref: RHEA:21835
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030759
name: methylquercetagetin 6-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine(1+) = 3',4',5-trihydroxy-3,6,7-trimethoxyflavone + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.84, RHEA:18720]
synonym: "6-OMT" RELATED [EC:2.1.1.84]
synonym: "flavonol 6-methyltransferase activity" EXACT [EC:2.1.1.84]
synonym: "flavonol 6-O-methyltransferase activity" RELATED [EC:2.1.1.84]
synonym: "S-adenosyl-L-methionine:3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone 6-O-methyltransferase activity" EXACT [EC:2.1.1.84]
xref: EC:2.1.1.84
xref: KEGG:R04505
xref: MetaCyc:2.1.1.84-RXN
xref: RHEA:18720
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030760
name: pyridine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + pyridine = N-methylpyridinium + S-adenosyl-L-homocysteine." [EC:2.1.1.87, RHEA:16896]
synonym: "pyridine methyltransferase activity" EXACT [EC:2.1.1.87]
synonym: "S-adenosyl-L-methionine:pyridine N-methyltransferase activity" EXACT [EC:2.1.1.87]
xref: EC:2.1.1.87
xref: KEGG:R02862
xref: MetaCyc:PYRIDINE-N-METHYLTRANSFERASE-RXN
xref: Reactome:REACT_104027 "Pyridine can be N-methylated, Danio rerio"
xref: Reactome:REACT_104283 "Pyridine can be N-methylated, Sus scrofa"
xref: Reactome:REACT_31394 "Pyridine can be N-methylated, Caenorhabditis elegans"
xref: Reactome:REACT_6930 "Pyridine can be N-methylated, Homo sapiens"
xref: Reactome:REACT_77666 "Pyridine can be N-methylated, Xenopus tropicalis"
xref: Reactome:REACT_87847 "Pyridine can be N-methylated, Mus musculus"
xref: Reactome:REACT_96312 "Pyridine can be N-methylated, Rattus norvegicus"
xref: Reactome:REACT_96778 "Pyridine can be N-methylated, Canis familiaris"
xref: RHEA:16896
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030761
name: 8-hydroxyquercitin 8-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,3',4',5,7,8-hexahydroxyflavone + S-adenosyl-L-methionine(1+) = 3,3',4',5,7-pentahydroxy-8-methoxyflavone + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.88, RHEA:16596]
synonym: "8-hydroxyquercetin 8-O-methyltransferase activity" EXACT [EC:2.1.1.88]
synonym: "flavonol 8-methyltransferase activity" EXACT [EC:2.1.1.88]
synonym: "flavonol 8-O-methyltransferase activity" RELATED [EC:2.1.1.88]
synonym: "S-adenosyl-L-methionine:3,3',4',5,7,8-hexahydroxyflavone 8-O-methyltransferase activity" EXACT [EC:2.1.1.88]
xref: EC:2.1.1.88
xref: KEGG:R04398
xref: MetaCyc:2.1.1.88-RXN
xref: RHEA:16596
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030762
name: tetrahydrocolumbamine 2-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-tetrahydrocolumbamine + S-adenosyl-L-methionine(1+) = S-adenosyl-L-homocysteine + H(+) + tetrahydropalmatine." [EC:2.1.1.89, RHEA:22539]
synonym: "S-adenosyl-L-methionine:5,8,13,13a-tetrahydrocolumbamine 2-O-methyltransferase activity" EXACT [EC:2.1.1.89]
synonym: "tetrahydrocolumbamine methyltransferase activity" EXACT [EC:2.1.1.89]
xref: EC:2.1.1.89
xref: KEGG:R04077
xref: MetaCyc:2.1.1.89-RXN
xref: RHEA:22539
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030763
name: isobutyraldoxime O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-methylpropanal oxime + S-adenosyl-L-methionine = 2-methylpropanal O-methyloxime + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.91, RHEA:10999]
synonym: "aldoxime methyltransferase activity" EXACT [EC:2.1.1.91]
synonym: "aldoxime O-methyltransferase activity" EXACT [EC:2.1.1.91]
synonym: "S-adenosyl-L-methionine:2-methylpropanal-oxime O-methyltransferase activity" EXACT [EC:2.1.1.91]
synonym: "S-adenosylmethionine:aldoxime O-methyltransferase activity" EXACT [EC:2.1.1.91]
xref: EC:2.1.1.91
xref: KEGG:R04169
xref: MetaCyc:ISOBUTYRALDOXIME-O-METHYLTRANSFERASE-RXN
xref: RHEA:10999
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030766
name: 11-O-demethyl-17-O-deacetylvindoline O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 11-O-demethyl-17-O-deacetylvindoline = S-adenosyl-L-homocysteine + 17-O-deacetylvindoline." [EC:2.1.1.94]
synonym: "11-demethyl-17-deacetylvindoline 11-methyltransferase activity" EXACT [EC:2.1.1.94]
synonym: "S-adenosyl-L-methionine:11-O-demethyl-17-O-deacetylvindoline 11-O-methyltransferase activity" EXACT [EC:2.1.1.94]
synonym: "S-adenosyl-L-methionine:16-hydroxytabersonine 16-O-methyltransferase activity" EXACT [EC:2.1.1.94]
synonym: "tabersonine 16-O-methyltransferase activity" EXACT [EC:2.1.1.94]
xref: EC:2.1.1.94
xref: MetaCyc:2.1.1.94-RXN
xref: RHEA:20995
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030767
name: 3-hydroxyanthranilate 4-C-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxyanthranilate + S-adenosyl-L-methionine = 3-hydroxy-4-methylanthranilate + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.97, RHEA:17836]
synonym: "3-hydroxyanthranilate 4-methyltransferase activity" EXACT [EC:2.1.1.97]
synonym: "S-adenosyl-L-methionine:3-hydroxyanthranilate 4-C-methyltransferase activity" EXACT [EC:2.1.1.97]
xref: EC:2.1.1.97
xref: KEGG:R02667
xref: MetaCyc:2.1.1.97-RXN
xref: RHEA:17836
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030768
name: 16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + deacetoxyvindoline + H(+)." [EC:2.1.1.99, RHEA:11339]
synonym: "16-methoxy-2,3-dihydro-3-hydroxytabersonine methyltransferase activity" EXACT [EC:2.1.1.99]
synonym: "3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase activity" EXACT [EC:2.1.1.99]
synonym: "NMT activity" EXACT [EC:2.1.1.99]
synonym: "S-adenosyl-L-methionine:16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase activity" EXACT [EC:2.1.1.99]
synonym: "S-adenosyl-L-methionine:3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase activity" EXACT [EC:2.1.1.99]
xref: EC:2.1.1.99
xref: KEGG:R04013
xref: MetaCyc:2.1.1.99-RXN
xref: RHEA:11339
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030769
name: macrocin O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + macrocin = S-adenosyl-L-homocysteine + H(+) + tylosin." [EC:2.1.1.101, RHEA:17272]
subset: gosubset_prok
synonym: "macrocin methyltransferase activity" EXACT [EC:2.1.1.101]
synonym: "S-adenosyl-L-methionine-macrocin O-methyltransferase activity" EXACT [EC:2.1.1.101]
synonym: "S-adenosyl-L-methionine:macrocin 3'''-O-methyltransferase activity" EXACT [EC:2.1.1.101]
xref: EC:2.1.1.101
xref: KEGG:R02858
xref: MetaCyc:MACROCIN-O-METHYLTRANSFERASE-RXN
xref: RHEA:17272
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030770
name: demethylmacrocin O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + demethylmacrocin = S-adenosyl-L-homocysteine + H(+) + macrocin." [EC:2.1.1.102, RHEA:17576]
synonym: "demethylmacrocin methyltransferase activity" EXACT [EC:2.1.1.102]
synonym: "S-adenosyl-L-methionine:demethylmacrocin 2'''-O-methyltransferase activity" EXACT [EC:2.1.1.102]
xref: EC:2.1.1.102
xref: KEGG:R02859
xref: MetaCyc:DEMETHYLMACROCIN-O-METHYLTRANSFERASE-RXN
xref: RHEA:17576
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030771
name: N-benzoyl-4-hydroxyanthranilate 4-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-benzoyl-4-hydroxyanthranilate + S-adenosyl-L-methionine(1+) = N-benzoyl-4-methoxyanthranilate + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.105, RHEA:17408]
synonym: "benzoyl-CoA:anthranilate N-benzoyltransferase" BROAD [EC:2.1.1.105]
synonym: "N-benzoyl-4-hydroxyanthranilate 4-methyltransferase activity" EXACT [EC:2.1.1.105]
synonym: "S-adenosyl-L-methionine:N-benzoyl-4-O-hydroxyanthranilate 4-O-methyltransferase activity" EXACT [EC:2.1.1.105]
xref: EC:2.1.1.105
xref: KEGG:R04421
xref: MetaCyc:2.1.1.105-RXN
xref: RHEA:17408
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030772
name: tryptophan 2-C-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + L-tryptophan = S-adenosyl-L-homocysteine + L-2-methyltryptophan + H(+)." [EC:2.1.1.106, RHEA:17324]
synonym: "S-adenosyl-L-methionine:L-tryptophan 2-C-methyltransferase activity" EXACT [EC:2.1.1.106]
synonym: "S-adenosylmethionine:tryptophan 2-methyltransferase activity" EXACT [EC:2.1.1.106]
synonym: "tryptophan 2-methyltransferase activity" EXACT [EC:2.1.1.106]
xref: EC:2.1.1.106
xref: KEGG:R08547
xref: MetaCyc:TRYPTOPHAN-2-C-METHYLTRANSFERASE-RXN
xref: RHEA:17324
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030773
name: 6-hydroxymellein O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-hydroxymellein + S-adenosyl-L-methionine = 6-methoxymellein + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.108, RHEA:15204]
synonym: "6-hydroxymellein methyltransferase activity" EXACT [EC:2.1.1.108]
synonym: "S-adenosyl-L-methionine:6-hydroxymellein 6-O-methyltransferase activity" EXACT [EC:2.1.1.108]
xref: EC:2.1.1.108
xref: KEGG:R03934
xref: MetaCyc:6-HYDROXYMELLEIN-O-METHYLTRANSFERASE-RXN
xref: RHEA:15204
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030774
name: anthranilate N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + anthranilate = N-methylanthranilate + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.111, RHEA:12183]
synonym: "anthranilic acid N-methyltransferase activity" EXACT [EC:2.1.1.111]
synonym: "S-adenosyl-L-methionine:anthranilate N-methyltransferase activity" EXACT [EC:2.1.1.111]
xref: EC:2.1.1.111
xref: KEGG:R00984
xref: MetaCyc:ANTHRANILATE-N-METHYLTRANSFERASE-RXN
xref: RHEA:12183
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030775
name: glucuronoxylan 4-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + glucuronoxylan D-glucuronate = S-adenosyl-L-homocysteine + glucuronoxylan 4-O-methyl-D-glucuronate." [EC:2.1.1.112]
synonym: "S-adenosyl-L-methionine:glucuronoxylan-D-glucuronate 4-O-methyltransferase activity" EXACT [EC:2.1.1.112]
xref: EC:2.1.1.112
xref: MetaCyc:GLUCURONOXYLAN-4-O-METHYLTRANSFERASE-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030776
name: (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline = S-adenosyl-L-homocysteine + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline." [EC:2.1.1.115]
synonym: "(RS)-tetrahydrobenzylisoquinoline N-methyltransferase activity" EXACT [EC:2.1.1.115]
synonym: "norreticuline N-methyltransferase activity" EXACT [EC:2.1.1.115]
synonym: "S-adenosyl-L-methionine:(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity" EXACT [EC:2.1.1.115]
xref: EC:2.1.1.115
xref: MetaCyc:2.1.1.115-RXN
xref: RHEA:13008
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030777
name: (S)-scoulerine 9-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-scoulerine + S-adenosyl-L-methionine(1+) = (S)-tetrahydrocolumbamine + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.117, RHEA:23811]
synonym: "S-adenosyl-L-methionine:(S)-scoclaurine 9-O-methyltransferase activity" EXACT [EC:2.1.1.117]
synonym: "S-adenosyl-L-methionine:(S)-scoulerine 9-O-methyltransferase activity" EXACT [EC:2.1.1.117]
xref: EC:2.1.1.117
xref: KEGG:R03835
xref: MetaCyc:2.1.1.117-RXN
xref: RHEA:23811
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030778
name: columbamine O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + columbamine = S-adenosyl-L-homocysteine + H(+) + palmatine." [EC:2.1.1.118, RHEA:15376]
synonym: "S-adenosyl-L-methionine:columbamine O-methyltransferase activity" EXACT [EC:2.1.1.118]
xref: EC:2.1.1.118
xref: KEGG:R03721
xref: MetaCyc:2.1.1.118-RXN
xref: RHEA:15376
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030779
name: 10-hydroxydihydrosanguinarine 10-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 10-hydroxydihydrosanguinarine + S-adenosyl-L-methionine(1+) = S-adenosyl-L-homocysteine + dihydrochelirubine + H(+)." [EC:2.1.1.119, RHEA:18544]
synonym: "S-adenosyl-L-methionine:10-hydroxydihydrosanguinarine 10-O-methyltransferase activity" EXACT [EC:2.1.1.119]
xref: EC:2.1.1.119
xref: KEGG:R04707
xref: MetaCyc:2.1.1.119-RXN
xref: RHEA:18544
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030780
name: 12-hydroxydihydrochelirubine 12-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 12-hydroxydihydrochelirubine + S-adenosyl-L-methionine(1+) = S-adenosyl-L-homocysteine + dihydromacarpine + H(+)." [EC:2.1.1.120, RHEA:21095]
synonym: "S-adenosyl-L-methionine:12-hydroxydihydrochelirubine 12-O-methyltransferase activity" EXACT [EC:2.1.1.120]
xref: EC:2.1.1.120
xref: KEGG:R04705
xref: MetaCyc:2.1.1.120-RXN
xref: RHEA:21095
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030781
name: 6-O-methylnorlaudanosoline 5'-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 6-O-methylnorlaudanosoline = S-adenosyl-L-homocysteine + nororientaline." [EC:2.1.1.121]
synonym: "S-adenosyl-L-methionine:6-O-methylnorlaudanosoline 5'-O-methyltransferase activity" EXACT [EC:2.1.1.121]
xref: EC:2.1.1.121
xref: MetaCyc:2.1.1.121-RXN
xref: RHEA:11895
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030782
name: (S)-tetrahydroprotoberberine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + (S)-7,8,13,14-tetrahydroprotoberberine = S-adenosyl-L-homocysteine + cis-N-methyl-(S)-7,8,13,14-tetrahydroprotoberberine." [EC:2.1.1.122]
synonym: "S-adenosyl-L-methionine:(S)-7,8,13,14-tetrahydroprotoberberine cis-N-methyltransferase activity" EXACT [EC:2.1.1.122]
synonym: "tetrahydroprotoberberine cis-N-methyltransferase activity" EXACT [EC:2.1.1.122]
xref: EC:2.1.1.122
xref: MetaCyc:2.1.1.122-RXN
xref: RHEA:12808
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030783
name: [cytochrome c]-methionine S-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + [cytochrome c]-methionine = S-adenosyl-L-homocysteine + [cytochrome c]-S-methyl-methionine." [EC:2.1.1.123]
synonym: "cytochrome c-methionine S-methyltransferase activity" EXACT [EC:2.1.1.123]
synonym: "S-adenosyl-L-methionine:cytochrome c-methionine S-methyltransferase activity" EXACT [EC:2.1.1.123]
xref: EC:2.1.1.123
xref: MetaCyc:2.1.1.123-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030784
name: 3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine = S-adenosyl-L-homocysteine + (S)-reticuline." [EC:2.1.1.116]
synonym: "S-adenosyl-L-methionine:3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase activity" EXACT [EC:2.1.1.116]
xref: EC:2.1.1.116
xref: MetaCyc:2.1.1.116-RXN
xref: RHEA:17792
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030785
name: [ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + [ribulose-1,5-bisphosphate carboxylase]-lysine = S-adenosyl-L-homocysteine + [ribulose-1,5-bisphosphate carboxylase]-N6-methyl-L-lysine." [EC:2.1.1.127]
synonym: "ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit epsilonN-methyltransferase activity" EXACT [EC:2.1.1.127]
synonym: "ribulose-bisphosphate carboxylase-lysine N-methyltransferase activity" EXACT [EC:2.1.1.127]
synonym: "ribulose-bisphosphate-carboxylase/oxygenase N-methyltransferase activity" EXACT [EC:2.1.1.127]
synonym: "RuBisCO LSMT activity" EXACT [EC:2.1.1.127]
synonym: "RuBisCO methyltransferase activity" EXACT [EC:2.1.1.127]
synonym: "S-adenosyl-L-methionine:3-phospho-D-glycerate-carboxy-lyase (dimerizing)-lysine 6-N-methyltransferase activity" EXACT [EC:2.1.1.127]
synonym: "S-adenosyl-L-methionine:3-phospho-D-glycerate-carboxy-lyase (dimerizing)-lysine N6-methyltransferase activity" EXACT [EC:2.1.1.127]
xref: EC:2.1.1.127
xref: MetaCyc:2.1.1.127-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030786
name: (RS)-norcoclaurine 6-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + (RS)-norcoclaurine = S-adenosyl-L-homocysteine + (RS)-coclaurine." [EC:2.1.1.128]
synonym: "S-adenosyl-L-methionine:(RS)-norcoclaurine 6-O-methyltransferase activity" EXACT [EC:2.1.1.128]
xref: EC:2.1.1.128
xref: MetaCyc:2.1.1.128-RXN
xref: RHEA:19944
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030787
name: inositol 4-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + myo-inositol = 1D-4-O-methyl-myo-inositol + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.129, RHEA:23251]
synonym: "myo-inositol 4-O-methyltransferase activity" EXACT [EC:2.1.1.129]
synonym: "myo-inositol 6-O-methyltransferase activity" RELATED [EC:2.1.1.129]
synonym: "S-adenosyl-L-methionine:1D-myo-inositol 4-methyltransferase activity" EXACT [EC:2.1.1.129]
synonym: "S-adenosyl-L-methionine:myo-inositol 4-O-methyltransferase activity" EXACT [EC:2.1.1.129]
xref: EC:2.1.1.129
xref: KEGG:R01190
xref: MetaCyc:2.1.1.129-RXN
xref: RHEA:23251
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030788
name: precorrin-2 C20-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-2 = S-adenosyl-L-homocysteine + H(+) + precorrin-3A." [EC:2.1.1.130, RHEA:16844]
subset: gosubset_prok
synonym: "S-adenosyl-L-methionine--precorrin-2 methyltransferase activity" EXACT [EC:2.1.1.130]
synonym: "S-adenosyl-L-methionine:precorrin-4 C20-methyltransferase activity" EXACT [EC:2.1.1.130]
xref: EC:2.1.1.130
xref: KEGG:R03948
xref: MetaCyc:2.1.1.130-RXN
xref: RHEA:16844
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030789
name: precorrin-3B C17-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-3B = S-adenosyl-L-homocysteine + precorrin 4." [EC:2.1.1.131]
subset: gosubset_prok
synonym: "CobJ" RELATED [EC:2.1.1.131]
synonym: "precorrin-3 methylase activity" EXACT [EC:2.1.1.131]
synonym: "precorrin-3 methyltransferase activity" EXACT [EC:2.1.1.131]
synonym: "S-adenosyl-L-methionine:precorrin-3B C17-methyltransferase activity" EXACT [EC:2.1.1.131]
xref: EC:2.1.1.131
xref: MetaCyc:2.1.1.131-RXN
xref: RHEA:12764
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030790
name: chlorophenol O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + trichlorophenol = S-adenosyl-L-homocysteine + trichloroanisole." [EC:2.1.1.136]
synonym: "halogenated phenol O-methyltransferase activity" BROAD [EC:2.1.1.136]
synonym: "S-adenosyl-L-methionine:trichlorophenol O-methyltransferase activity" EXACT [EC:2.1.1.136]
synonym: "trichlorophenol O-methyltransferase activity" EXACT [EC:2.1.1.136]
xref: EC:2.1.1.136
xref: MetaCyc:2.1.1.136-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030791
name: arsenite methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate." [EC:2.1.1.137]
comment: Note that the enzyme arsenite methyltransferase also has methylarsonite methyltransferase activity (GO:0030792).
synonym: "S-adenosyl-L-methionine:arsenic(III) methyltransferase activity" EXACT [EC:2.1.1.137]
synonym: "S-adenosyl-L-methionine:arsenite As-methyltransferase activity" EXACT [EC:2.1.1.137]
synonym: "S-adenosyl-L-methionine:methylarsonite As-methyltransferase activity" EXACT [EC:2.1.1.137]
xref: EC:2.1.1.137
xref: MetaCyc:2.1.1.137-RXN
xref: UM-BBD_reactionID:r0805
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030792
name: methylarsonite methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + methylarsonite = S-adenosyl-L-homocysteine + dimethylarsinate." [EC:2.1.1.138]
comment: Note that EC:2.1.1.138 was deleted from EC as the reaction is performed by arsenite methyltransferase (EC:2.1.1.137).
xref: EC:2.1.1.-
xref: MetaCyc:2.1.1.138-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030793
name: 3'-demethylstaurosporine O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-demethylstaurosporine + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + H(+) + staurosporine." [EC:2.1.1.139, RHEA:11699]
synonym: "3'-demethoxy-3'-hydroxystaurosporine O-methyltransferase activity" EXACT [EC:2.1.1.139]
synonym: "S-adenosyl-L-methionine:3'-demethylstaurosporine O-methyltransferase activity" EXACT [EC:2.1.1.139]
synonym: "staurosporine synthase activity" EXACT [EC:2.1.1.139]
xref: EC:2.1.1.139
xref: KEGG:R05757
xref: MetaCyc:2.1.1.139-RXN
xref: RHEA:11699
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030794
name: (S)-coclaurine-N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + (S)-coclaurine = S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine." [EC:2.1.1.140]
synonym: "S-adenosyl-L-methionine:(S)-coclaurine-N-methyltransferase activity" EXACT [EC:2.1.1.140]
xref: EC:2.1.1.140
xref: MetaCyc:2.1.1.140-RXN
xref: RHEA:17412
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030795
name: jasmonate O-methyltransferase activity
namespace: molecular_function
alt_id: GO:0045546
def: "Catalysis of the reaction: S-adenosyl-L-methionine + jasmonate = S-adenosyl-L-homocysteine + methyljasmonate." [EC:2.1.1.141]
synonym: "jasmonic acid carboxyl methyltransferase activity" EXACT [EC:2.1.1.141]
synonym: "S-adenosyl-L-methionine:jasmonate O-methyltransferase activity" EXACT [EC:2.1.1.141]
synonym: "S-adenosyl-L-methionine:jasmonic acid carboxyl methyltransferase activity" EXACT []
xref: EC:2.1.1.141
xref: MetaCyc:RXN1F-28
xref: RHEA:13352
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030796
name: cycloartenol 24-C-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + cycloartenol = (24R)-24-methylcycloart-25-en-3beta-ol + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.142, RHEA:13140]
synonym: "S-adenosyl-L-methionine:cycloartenol 24-C-methyltransferase activity" EXACT [EC:2.1.1.142]
synonym: "sterol C-methyltransferase activity" BROAD [EC:2.1.1.142]
xref: EC:2.1.1.142
xref: KEGG:R05760
xref: MetaCyc:2.1.1.142-RXN
xref: RHEA:13140
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030797
name: 24-methylenesterol C-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 24-methylidenelophenol + S-adenosyl-L-methionine(1+) = (Z)-24-ethylidenelophenol + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.143, RHEA:21047]
synonym: "24-methylenelophenol C-24(1)-methyltransferase activity" EXACT [EC:2.1.1.143]
synonym: "24-methylenelophenol C-241-methyltransferase activity" EXACT [EC:2.1.1.143]
synonym: "S-adenosyl-L-methionine:24-methylenelophenol C-methyltransferase activity" EXACT [EC:2.1.1.143]
synonym: "SMT(2) activity" NARROW [EC:2.1.1.143]
synonym: "SMT2" RELATED [EC:2.1.1.143]
xref: EC:2.1.1.143
xref: KEGG:R05776
xref: MetaCyc:2.1.1.143-RXN
xref: RHEA:21047
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030798
name: trans-aconitate 2-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + trans-aconitate = (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine." [EC:2.1.1.144, RHEA:14972]
subset: gosubset_prok
synonym: "S-adenosyl-L-methionine:(E)-prop-1-ene-1,2,3-tricarboxylate 2'-O-methyltransferase activity" EXACT [EC:2.1.1.144]
xref: EC:2.1.1.144
xref: KEGG:R05763
xref: MetaCyc:RXN0-2441
xref: RHEA:14972
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030799
name: regulation of cyclic nucleotide metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of cyclic nucleotide metabolism" EXACT []
is_a: GO:0006140 ! regulation of nucleotide metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009187 ! cyclic nucleotide metabolic process
relationship: regulates GO:0009187 ! cyclic nucleotide metabolic process

[Term]
id: GO:0030800
name: negative regulation of cyclic nucleotide metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation of cyclic nucleotide metabolic process" EXACT []
synonym: "down-regulation of cyclic nucleotide metabolic process" EXACT []
synonym: "downregulation of cyclic nucleotide metabolic process" EXACT []
synonym: "inhibition of cyclic nucleotide metabolic process" NARROW []
synonym: "negative regulation of cyclic nucleotide metabolism" EXACT []
is_a: GO:0030799 ! regulation of cyclic nucleotide metabolic process
is_a: GO:0045980 ! negative regulation of nucleotide metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009187 ! cyclic nucleotide metabolic process
relationship: negatively_regulates GO:0009187 ! cyclic nucleotide metabolic process

[Term]
id: GO:0030801
name: positive regulation of cyclic nucleotide metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides." [GOC:mah]
subset: gosubset_prok
synonym: "activation of cyclic nucleotide metabolic process" NARROW []
synonym: "positive regulation of cyclic nucleotide metabolism" EXACT []
synonym: "stimulation of cyclic nucleotide metabolic process" NARROW []
synonym: "up regulation of cyclic nucleotide metabolic process" EXACT []
synonym: "up-regulation of cyclic nucleotide metabolic process" EXACT []
synonym: "upregulation of cyclic nucleotide metabolic process" EXACT []
is_a: GO:0030799 ! regulation of cyclic nucleotide metabolic process
is_a: GO:0045981 ! positive regulation of nucleotide metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009187 ! cyclic nucleotide metabolic process
relationship: positively_regulates GO:0009187 ! cyclic nucleotide metabolic process

[Term]
id: GO:0030802
name: regulation of cyclic nucleotide biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cyclic nucleotides." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of cyclic nucleotide anabolism" EXACT []
synonym: "regulation of cyclic nucleotide biosynthesis" EXACT []
synonym: "regulation of cyclic nucleotide formation" EXACT []
synonym: "regulation of cyclic nucleotide synthesis" EXACT []
is_a: GO:0030799 ! regulation of cyclic nucleotide metabolic process
is_a: GO:0030808 ! regulation of nucleotide biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009190 ! cyclic nucleotide biosynthetic process
relationship: regulates GO:0009190 ! cyclic nucleotide biosynthetic process

[Term]
id: GO:0030803
name: negative regulation of cyclic nucleotide biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cyclic nucleotides." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation of cyclic nucleotide biosynthetic process" EXACT []
synonym: "down-regulation of cyclic nucleotide biosynthetic process" EXACT []
synonym: "downregulation of cyclic nucleotide biosynthetic process" EXACT []
synonym: "inhibition of cyclic nucleotide biosynthetic process" NARROW []
synonym: "negative regulation of cyclic nucleotide anabolism" EXACT []
synonym: "negative regulation of cyclic nucleotide biosynthesis" EXACT []
synonym: "negative regulation of cyclic nucleotide formation" EXACT []
synonym: "negative regulation of cyclic nucleotide synthesis" EXACT []
is_a: GO:0030800 ! negative regulation of cyclic nucleotide metabolic process
is_a: GO:0030802 ! regulation of cyclic nucleotide biosynthetic process
is_a: GO:0030809 ! negative regulation of nucleotide biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009190 ! cyclic nucleotide biosynthetic process
relationship: negatively_regulates GO:0009190 ! cyclic nucleotide biosynthetic process

[Term]
id: GO:0030804
name: positive regulation of cyclic nucleotide biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cyclic nucleotides." [GOC:mah]
subset: gosubset_prok
synonym: "activation of cyclic nucleotide biosynthetic process" NARROW []
synonym: "positive regulation of cyclic nucleotide anabolism" EXACT []
synonym: "positive regulation of cyclic nucleotide biosynthesis" EXACT []
synonym: "positive regulation of cyclic nucleotide formation" EXACT []
synonym: "positive regulation of cyclic nucleotide synthesis" EXACT []
synonym: "stimulation of cyclic nucleotide biosynthetic process" NARROW []
synonym: "up regulation of cyclic nucleotide biosynthetic process" EXACT []
synonym: "up-regulation of cyclic nucleotide biosynthetic process" EXACT []
synonym: "upregulation of cyclic nucleotide biosynthetic process" EXACT []
is_a: GO:0030801 ! positive regulation of cyclic nucleotide metabolic process
is_a: GO:0030802 ! regulation of cyclic nucleotide biosynthetic process
is_a: GO:0030810 ! positive regulation of nucleotide biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009190 ! cyclic nucleotide biosynthetic process
relationship: positively_regulates GO:0009190 ! cyclic nucleotide biosynthetic process

[Term]
id: GO:0030805
name: regulation of cyclic nucleotide catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cyclic nucleotides." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of cyclic nucleotide breakdown" EXACT []
synonym: "regulation of cyclic nucleotide catabolism" EXACT []
synonym: "regulation of cyclic nucleotide degradation" EXACT []
is_a: GO:0030799 ! regulation of cyclic nucleotide metabolic process
is_a: GO:0030811 ! regulation of nucleotide catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009214 ! cyclic nucleotide catabolic process
relationship: regulates GO:0009214 ! cyclic nucleotide catabolic process

[Term]
id: GO:0030806
name: negative regulation of cyclic nucleotide catabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways resulting in the breakdown of cyclic nucleotides." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation of cyclic nucleotide catabolic process" EXACT []
synonym: "down-regulation of cyclic nucleotide catabolic process" EXACT []
synonym: "downregulation of cyclic nucleotide catabolic process" EXACT []
synonym: "inhibition of cyclic nucleotide catabolic process" NARROW []
synonym: "negative regulation of cyclic nucleotide breakdown" EXACT []
synonym: "negative regulation of cyclic nucleotide catabolism" EXACT []
synonym: "negative regulation of cyclic nucleotide degradation" EXACT []
is_a: GO:0030800 ! negative regulation of cyclic nucleotide metabolic process
is_a: GO:0030805 ! regulation of cyclic nucleotide catabolic process
is_a: GO:0030812 ! negative regulation of nucleotide catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009214 ! cyclic nucleotide catabolic process
relationship: negatively_regulates GO:0009214 ! cyclic nucleotide catabolic process

[Term]
id: GO:0030807
name: positive regulation of cyclic nucleotide catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chemical reactions and pathways resulting in the breakdown of cyclic nucleotides." [GOC:mah]
subset: gosubset_prok
synonym: "activation of cyclic nucleotide catabolic process" NARROW []
synonym: "positive regulation of cyclic nucleotide breakdown" EXACT []
synonym: "positive regulation of cyclic nucleotide catabolism" EXACT []
synonym: "positive regulation of cyclic nucleotide degradation" EXACT []
synonym: "stimulation of cyclic nucleotide catabolic process" NARROW []
synonym: "up regulation of cyclic nucleotide catabolic process" EXACT []
synonym: "up-regulation of cyclic nucleotide catabolic process" EXACT []
synonym: "upregulation of cyclic nucleotide catabolic process" EXACT []
is_a: GO:0030801 ! positive regulation of cyclic nucleotide metabolic process
is_a: GO:0030805 ! regulation of cyclic nucleotide catabolic process
is_a: GO:0030813 ! positive regulation of nucleotide catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009214 ! cyclic nucleotide catabolic process
relationship: positively_regulates GO:0009214 ! cyclic nucleotide catabolic process

[Term]
id: GO:0030808
name: regulation of nucleotide biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of nucleotide anabolism" EXACT []
synonym: "regulation of nucleotide biosynthesis" EXACT []
synonym: "regulation of nucleotide formation" EXACT []
synonym: "regulation of nucleotide synthesis" EXACT []
is_a: GO:0006140 ! regulation of nucleotide metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009165 ! nucleotide biosynthetic process
relationship: regulates GO:0009165 ! nucleotide biosynthetic process

[Term]
id: GO:0030809
name: negative regulation of nucleotide biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation of nucleotide biosynthetic process" EXACT []
synonym: "down-regulation of nucleotide biosynthetic process" EXACT []
synonym: "downregulation of nucleotide biosynthetic process" EXACT []
synonym: "inhibition of nucleotide biosynthetic process" NARROW []
synonym: "negative regulation of nucleotide anabolism" EXACT []
synonym: "negative regulation of nucleotide biosynthesis" EXACT []
synonym: "negative regulation of nucleotide formation" EXACT []
synonym: "negative regulation of nucleotide synthesis" EXACT []
is_a: GO:0030808 ! regulation of nucleotide biosynthetic process
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0045980 ! negative regulation of nucleotide metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009165 ! nucleotide biosynthetic process
relationship: negatively_regulates GO:0009165 ! nucleotide biosynthetic process

[Term]
id: GO:0030810
name: positive regulation of nucleotide biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides." [GOC:mah]
subset: gosubset_prok
synonym: "activation of nucleotide biosynthetic process" NARROW []
synonym: "positive regulation of nucleotide anabolism" EXACT []
synonym: "positive regulation of nucleotide biosynthesis" EXACT []
synonym: "positive regulation of nucleotide formation" EXACT []
synonym: "positive regulation of nucleotide synthesis" EXACT []
synonym: "stimulation of nucleotide biosynthetic process" NARROW []
synonym: "up regulation of nucleotide biosynthetic process" EXACT []
synonym: "up-regulation of nucleotide biosynthetic process" EXACT []
synonym: "upregulation of nucleotide biosynthetic process" EXACT []
is_a: GO:0030808 ! regulation of nucleotide biosynthetic process
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0045981 ! positive regulation of nucleotide metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009165 ! nucleotide biosynthetic process
relationship: positively_regulates GO:0009165 ! nucleotide biosynthetic process

[Term]
id: GO:0030811
name: regulation of nucleotide catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of nucleotide breakdown" EXACT []
synonym: "regulation of nucleotide catabolism" EXACT []
synonym: "regulation of nucleotide degradation" EXACT []
is_a: GO:0006140 ! regulation of nucleotide metabolic process
is_a: GO:0031329 ! regulation of cellular catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009166 ! nucleotide catabolic process
relationship: regulates GO:0009166 ! nucleotide catabolic process

[Term]
id: GO:0030812
name: negative regulation of nucleotide catabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation of nucleotide catabolic process" EXACT []
synonym: "down-regulation of nucleotide catabolic process" EXACT []
synonym: "downregulation of nucleotide catabolic process" EXACT []
synonym: "inhibition of nucleotide catabolic process" NARROW []
synonym: "negative regulation of nucleotide breakdown" EXACT []
synonym: "negative regulation of nucleotide catabolism" EXACT []
synonym: "negative regulation of nucleotide degradation" EXACT []
is_a: GO:0030811 ! regulation of nucleotide catabolic process
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:0045980 ! negative regulation of nucleotide metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009166 ! nucleotide catabolic process
relationship: negatively_regulates GO:0009166 ! nucleotide catabolic process

[Term]
id: GO:0030813
name: positive regulation of nucleotide catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides." [GOC:mah]
subset: gosubset_prok
synonym: "activation of nucleotide catabolic process" NARROW []
synonym: "positive regulation of nucleotide breakdown" EXACT []
synonym: "positive regulation of nucleotide catabolism" EXACT []
synonym: "positive regulation of nucleotide degradation" EXACT []
synonym: "stimulation of nucleotide catabolic process" NARROW []
synonym: "up regulation of nucleotide catabolic process" EXACT []
synonym: "up-regulation of nucleotide catabolic process" EXACT []
synonym: "upregulation of nucleotide catabolic process" EXACT []
is_a: GO:0030811 ! regulation of nucleotide catabolic process
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:0045981 ! positive regulation of nucleotide metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009166 ! nucleotide catabolic process
relationship: positively_regulates GO:0009166 ! nucleotide catabolic process

[Term]
id: GO:0030814
name: regulation of cAMP metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of 3',5' cAMP metabolic process" EXACT []
synonym: "regulation of 3',5' cAMP metabolism" EXACT []
synonym: "regulation of 3',5'-cAMP metabolic process" EXACT []
synonym: "regulation of 3',5'-cAMP metabolism" EXACT []
synonym: "regulation of adenosine 3',5'-cyclophosphate metabolic process" EXACT []
synonym: "regulation of adenosine 3',5'-cyclophosphate metabolism" EXACT []
synonym: "regulation of cAMP metabolism" EXACT []
synonym: "regulation of cyclic AMP metabolic process" EXACT []
synonym: "regulation of cyclic AMP metabolism" EXACT []
is_a: GO:0030799 ! regulation of cyclic nucleotide metabolic process
is_a: GO:1900542 ! regulation of purine nucleotide metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0046058 ! cAMP metabolic process
relationship: regulates GO:0046058 ! cAMP metabolic process

[Term]
id: GO:0030815
name: negative regulation of cAMP metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation of cAMP metabolic process" EXACT []
synonym: "down-regulation of cAMP metabolic process" EXACT []
synonym: "downregulation of cAMP metabolic process" EXACT []
synonym: "inhibition of cAMP metabolic process" NARROW []
synonym: "negative regulation of 3',5' cAMP metabolic process" EXACT []
synonym: "negative regulation of 3',5' cAMP metabolism" EXACT []
synonym: "negative regulation of 3',5'-cAMP metabolic process" EXACT []
synonym: "negative regulation of 3',5'-cAMP metabolism" EXACT []
synonym: "negative regulation of adenosine 3',5'-cyclophosphate metabolic process" EXACT []
synonym: "negative regulation of adenosine 3',5'-cyclophosphate metabolism" EXACT []
synonym: "negative regulation of cAMP metabolism" EXACT []
synonym: "negative regulation of cyclic AMP metabolic process" EXACT []
synonym: "negative regulation of cyclic AMP metabolism" EXACT []
is_a: GO:0030800 ! negative regulation of cyclic nucleotide metabolic process
is_a: GO:0030814 ! regulation of cAMP metabolic process
is_a: GO:1900543 ! negative regulation of purine nucleotide metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0046058 ! cAMP metabolic process
relationship: negatively_regulates GO:0046058 ! cAMP metabolic process

[Term]
id: GO:0030816
name: positive regulation of cAMP metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah]
subset: gosubset_prok
synonym: "activation of cAMP metabolic process" NARROW []
synonym: "positive regulation of 3',5' cAMP metabolic process" EXACT []
synonym: "positive regulation of 3',5' cAMP metabolism" EXACT []
synonym: "positive regulation of 3',5'-cAMP metabolic process" EXACT []
synonym: "positive regulation of 3',5'-cAMP metabolism" EXACT []
synonym: "positive regulation of adenosine 3',5'-cyclophosphate metabolic process" EXACT []
synonym: "positive regulation of adenosine 3',5'-cyclophosphate metabolism" EXACT []
synonym: "positive regulation of cAMP metabolism" EXACT []
synonym: "positive regulation of cyclic AMP metabolic process" EXACT []
synonym: "positive regulation of cyclic AMP metabolism" EXACT []
synonym: "stimulation of cAMP metabolic process" NARROW []
synonym: "up regulation of cAMP metabolic process" EXACT []
synonym: "up-regulation of cAMP metabolic process" EXACT []
synonym: "upregulation of cAMP metabolic process" EXACT []
is_a: GO:0030801 ! positive regulation of cyclic nucleotide metabolic process
is_a: GO:0030814 ! regulation of cAMP metabolic process
is_a: GO:1900544 ! positive regulation of purine nucleotide metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0046058 ! cAMP metabolic process
relationship: positively_regulates GO:0046058 ! cAMP metabolic process

[Term]
id: GO:0030817
name: regulation of cAMP biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of 3',5' cAMP biosynthesis" EXACT []
synonym: "regulation of 3',5' cAMP biosynthetic process" EXACT []
synonym: "regulation of 3',5'-cAMP biosynthesis" EXACT []
synonym: "regulation of 3',5'-cAMP biosynthetic process" EXACT []
synonym: "regulation of adenosine 3',5'-cyclophosphate biosynthesis" EXACT []
synonym: "regulation of adenosine 3',5'-cyclophosphate biosynthetic process" EXACT []
synonym: "regulation of cAMP anabolism" EXACT []
synonym: "regulation of cAMP biosynthesis" EXACT []
synonym: "regulation of cAMP formation" EXACT []
synonym: "regulation of cAMP synthesis" EXACT []
synonym: "regulation of cyclic AMP biosynthesis" EXACT []
synonym: "regulation of cyclic AMP biosynthetic process" EXACT []
is_a: GO:0030802 ! regulation of cyclic nucleotide biosynthetic process
is_a: GO:0030814 ! regulation of cAMP metabolic process
is_a: GO:1900371 ! regulation of purine nucleotide biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006171 ! cAMP biosynthetic process
relationship: regulates GO:0006171 ! cAMP biosynthetic process

[Term]
id: GO:0030818
name: negative regulation of cAMP biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation of cAMP biosynthetic process" EXACT []
synonym: "down-regulation of cAMP biosynthetic process" EXACT []
synonym: "downregulation of cAMP biosynthetic process" EXACT []
synonym: "inhibition of cAMP biosynthetic process" NARROW []
synonym: "negative regulation of 3',5' cAMP biosynthesis" EXACT []
synonym: "negative regulation of 3',5' cAMP biosynthetic process" EXACT []
synonym: "negative regulation of 3',5'-cAMP biosynthesis" EXACT []
synonym: "negative regulation of 3',5'-cAMP biosynthetic process" EXACT []
synonym: "negative regulation of adenosine 3',5'-cyclophosphate biosynthesis" EXACT []
synonym: "negative regulation of adenosine 3',5'-cyclophosphate biosynthetic process" EXACT []
synonym: "negative regulation of cAMP anabolism" EXACT []
synonym: "negative regulation of cAMP biosynthesis" EXACT []
synonym: "negative regulation of cAMP formation" EXACT []
synonym: "negative regulation of cAMP synthesis" EXACT []
synonym: "negative regulation of cyclic AMP biosynthesis" EXACT []
synonym: "negative regulation of cyclic AMP biosynthetic process" EXACT []
is_a: GO:0030803 ! negative regulation of cyclic nucleotide biosynthetic process
is_a: GO:0030815 ! negative regulation of cAMP metabolic process
is_a: GO:0030817 ! regulation of cAMP biosynthetic process
is_a: GO:1900372 ! negative regulation of purine nucleotide biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006171 ! cAMP biosynthetic process
relationship: negatively_regulates GO:0006171 ! cAMP biosynthetic process

[Term]
id: GO:0030819
name: positive regulation of cAMP biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah]
subset: gosubset_prok
synonym: "activation of cAMP biosynthetic process" NARROW []
synonym: "positive regulation of 3',5' cAMP biosynthesis" EXACT []
synonym: "positive regulation of 3',5' cAMP biosynthetic process" EXACT []
synonym: "positive regulation of 3',5'-cAMP biosynthesis" EXACT []
synonym: "positive regulation of 3',5'-cAMP biosynthetic process" EXACT []
synonym: "positive regulation of adenosine 3',5'-cyclophosphate biosynthesis" EXACT []
synonym: "positive regulation of adenosine 3',5'-cyclophosphate biosynthetic process" EXACT []
synonym: "positive regulation of cAMP anabolism" EXACT []
synonym: "positive regulation of cAMP biosynthesis" EXACT []
synonym: "positive regulation of cAMP formation" EXACT []
synonym: "positive regulation of cAMP synthesis" EXACT []
synonym: "positive regulation of cyclic AMP biosynthesis" EXACT []
synonym: "positive regulation of cyclic AMP biosynthetic process" EXACT []
synonym: "stimulation of cAMP biosynthetic process" NARROW []
synonym: "up regulation of cAMP biosynthetic process" EXACT []
synonym: "up-regulation of cAMP biosynthetic process" EXACT []
synonym: "upregulation of cAMP biosynthetic process" EXACT []
is_a: GO:0030804 ! positive regulation of cyclic nucleotide biosynthetic process
is_a: GO:0030816 ! positive regulation of cAMP metabolic process
is_a: GO:0030817 ! regulation of cAMP biosynthetic process
is_a: GO:1900373 ! positive regulation of purine nucleotide biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006171 ! cAMP biosynthetic process
relationship: positively_regulates GO:0006171 ! cAMP biosynthetic process

[Term]
id: GO:0030820
name: regulation of cAMP catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of 3',5' cAMP catabolic process" EXACT []
synonym: "regulation of 3',5' cAMP catabolism" EXACT []
synonym: "regulation of 3',5'-cAMP catabolic process" EXACT []
synonym: "regulation of 3',5'-cAMP catabolism" EXACT []
synonym: "regulation of adenosine 3',5'-cyclophosphate catabolic process" EXACT []
synonym: "regulation of adenosine 3',5'-cyclophosphate catabolism" EXACT []
synonym: "regulation of cAMP breakdown" EXACT []
synonym: "regulation of cAMP catabolism" EXACT []
synonym: "regulation of cAMP degradation" EXACT []
synonym: "regulation of cyclic AMP catabolic process" EXACT []
synonym: "regulation of cyclic AMP catabolism" EXACT []
is_a: GO:0030805 ! regulation of cyclic nucleotide catabolic process
is_a: GO:0030814 ! regulation of cAMP metabolic process
is_a: GO:0033121 ! regulation of purine nucleotide catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006198 ! cAMP catabolic process
relationship: regulates GO:0006198 ! cAMP catabolic process

[Term]
id: GO:0030821
name: negative regulation of cAMP catabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation of cAMP catabolic process" EXACT []
synonym: "down-regulation of cAMP catabolic process" EXACT []
synonym: "downregulation of cAMP catabolic process" EXACT []
synonym: "inhibition of cAMP catabolic process" NARROW []
synonym: "negative regulation of 3',5' cAMP catabolic process" EXACT []
synonym: "negative regulation of 3',5' cAMP catabolism" EXACT []
synonym: "negative regulation of 3',5'-cAMP catabolic process" EXACT []
synonym: "negative regulation of 3',5'-cAMP catabolism" EXACT []
synonym: "negative regulation of adenosine 3',5'-cyclophosphate catabolic process" EXACT []
synonym: "negative regulation of adenosine 3',5'-cyclophosphate catabolism" EXACT []
synonym: "negative regulation of cAMP breakdown" EXACT []
synonym: "negative regulation of cAMP catabolism" EXACT []
synonym: "negative regulation of cAMP degradation" EXACT []
synonym: "negative regulation of cyclic AMP catabolic process" EXACT []
synonym: "negative regulation of cyclic AMP catabolism" EXACT []
is_a: GO:0030806 ! negative regulation of cyclic nucleotide catabolic process
is_a: GO:0030815 ! negative regulation of cAMP metabolic process
is_a: GO:0030820 ! regulation of cAMP catabolic process
is_a: GO:0033122 ! negative regulation of purine nucleotide catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006198 ! cAMP catabolic process
relationship: negatively_regulates GO:0006198 ! cAMP catabolic process

[Term]
id: GO:0030822
name: positive regulation of cAMP catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah]
subset: gosubset_prok
synonym: "activation of cAMP catabolic process" NARROW []
synonym: "positive regulation of 3',5' cAMP catabolic process" EXACT []
synonym: "positive regulation of 3',5' cAMP catabolism" EXACT []
synonym: "positive regulation of 3',5'-cAMP catabolic process" EXACT []
synonym: "positive regulation of 3',5'-cAMP catabolism" EXACT []
synonym: "positive regulation of adenosine 3',5'-cyclophosphate catabolic process" EXACT []
synonym: "positive regulation of adenosine 3',5'-cyclophosphate catabolism" EXACT []
synonym: "positive regulation of cAMP breakdown" EXACT []
synonym: "positive regulation of cAMP catabolism" EXACT []
synonym: "positive regulation of cAMP degradation" EXACT []
synonym: "positive regulation of cyclic AMP catabolic process" EXACT []
synonym: "positive regulation of cyclic AMP catabolism" EXACT []
synonym: "stimulation of cAMP catabolic process" NARROW []
synonym: "up regulation of cAMP catabolic process" EXACT []
synonym: "up-regulation of cAMP catabolic process" EXACT []
synonym: "upregulation of cAMP catabolic process" EXACT []
is_a: GO:0030807 ! positive regulation of cyclic nucleotide catabolic process
is_a: GO:0030816 ! positive regulation of cAMP metabolic process
is_a: GO:0030820 ! regulation of cAMP catabolic process
is_a: GO:0033123 ! positive regulation of purine nucleotide catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006198 ! cAMP catabolic process
relationship: positively_regulates GO:0006198 ! cAMP catabolic process

[Term]
id: GO:0030823
name: regulation of cGMP metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cGMP." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of cGMP metabolism" EXACT []
is_a: GO:0030799 ! regulation of cyclic nucleotide metabolic process
is_a: GO:1900542 ! regulation of purine nucleotide metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0046068 ! cGMP metabolic process
relationship: regulates GO:0046068 ! cGMP metabolic process

[Term]
id: GO:0030824
name: negative regulation of cGMP metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving cGMP." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation of cGMP metabolic process" EXACT []
synonym: "down-regulation of cGMP metabolic process" EXACT []
synonym: "downregulation of cGMP metabolic process" EXACT []
synonym: "inhibition of cGMP metabolic process" NARROW []
synonym: "negative regulation of cGMP metabolism" EXACT []
is_a: GO:0030800 ! negative regulation of cyclic nucleotide metabolic process
is_a: GO:0030823 ! regulation of cGMP metabolic process
is_a: GO:1900543 ! negative regulation of purine nucleotide metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0046068 ! cGMP metabolic process
relationship: negatively_regulates GO:0046068 ! cGMP metabolic process

[Term]
id: GO:0030825
name: positive regulation of cGMP metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving cGMP." [GOC:mah]
subset: gosubset_prok
synonym: "activation of cGMP metabolic process" NARROW []
synonym: "positive regulation of cGMP metabolism" EXACT []
synonym: "stimulation of cGMP metabolic process" NARROW []
synonym: "up regulation of cGMP metabolic process" EXACT []
synonym: "up-regulation of cGMP metabolic process" EXACT []
synonym: "upregulation of cGMP metabolic process" EXACT []
is_a: GO:0030801 ! positive regulation of cyclic nucleotide metabolic process
is_a: GO:0030823 ! regulation of cGMP metabolic process
is_a: GO:1900544 ! positive regulation of purine nucleotide metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0046068 ! cGMP metabolic process
relationship: positively_regulates GO:0046068 ! cGMP metabolic process

[Term]
id: GO:0030826
name: regulation of cGMP biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cGMP." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of cGMP anabolism" EXACT []
synonym: "regulation of cGMP biosynthesis" EXACT []
synonym: "regulation of cGMP formation" EXACT []
synonym: "regulation of cGMP synthesis" EXACT []
is_a: GO:0030802 ! regulation of cyclic nucleotide biosynthetic process
is_a: GO:0030823 ! regulation of cGMP metabolic process
is_a: GO:1900371 ! regulation of purine nucleotide biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006182 ! cGMP biosynthetic process
relationship: regulates GO:0006182 ! cGMP biosynthetic process

[Term]
id: GO:0030827
name: negative regulation of cGMP biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cGMP." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation of cGMP biosynthetic process" EXACT []
synonym: "down-regulation of cGMP biosynthetic process" EXACT []
synonym: "downregulation of cGMP biosynthetic process" EXACT []
synonym: "inhibition of cGMP biosynthetic process" NARROW []
synonym: "negative regulation of cGMP anabolism" EXACT []
synonym: "negative regulation of cGMP biosynthesis" EXACT []
synonym: "negative regulation of cGMP formation" EXACT []
synonym: "negative regulation of cGMP synthesis" EXACT []
is_a: GO:0030803 ! negative regulation of cyclic nucleotide biosynthetic process
is_a: GO:0030824 ! negative regulation of cGMP metabolic process
is_a: GO:0030826 ! regulation of cGMP biosynthetic process
is_a: GO:1900372 ! negative regulation of purine nucleotide biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006182 ! cGMP biosynthetic process
relationship: negatively_regulates GO:0006182 ! cGMP biosynthetic process

[Term]
id: GO:0030828
name: positive regulation of cGMP biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cGMP." [GOC:mah]
subset: gosubset_prok
synonym: "activation of cGMP biosynthetic process" NARROW []
synonym: "positive regulation of cGMP anabolism" EXACT []
synonym: "positive regulation of cGMP biosynthesis" EXACT []
synonym: "positive regulation of cGMP formation" EXACT []
synonym: "positive regulation of cGMP synthesis" EXACT []
synonym: "stimulation of cGMP biosynthetic process" NARROW []
synonym: "up regulation of cGMP biosynthetic process" EXACT []
synonym: "up-regulation of cGMP biosynthetic process" EXACT []
synonym: "upregulation of cGMP biosynthetic process" EXACT []
is_a: GO:0030804 ! positive regulation of cyclic nucleotide biosynthetic process
is_a: GO:0030825 ! positive regulation of cGMP metabolic process
is_a: GO:0030826 ! regulation of cGMP biosynthetic process
is_a: GO:1900373 ! positive regulation of purine nucleotide biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006182 ! cGMP biosynthetic process
relationship: positively_regulates GO:0006182 ! cGMP biosynthetic process

[Term]
id: GO:0030829
name: regulation of cGMP catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cGMP." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of cGMP breakdown" EXACT []
synonym: "regulation of cGMP catabolism" EXACT []
synonym: "regulation of cGMP degradation" EXACT []
is_a: GO:0030805 ! regulation of cyclic nucleotide catabolic process
is_a: GO:0030823 ! regulation of cGMP metabolic process
is_a: GO:0033121 ! regulation of purine nucleotide catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0046069 ! cGMP catabolic process
relationship: regulates GO:0046069 ! cGMP catabolic process

[Term]
id: GO:0030830
name: negative regulation of cGMP catabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cGMP." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation of cGMP catabolic process" EXACT []
synonym: "down-regulation of cGMP catabolic process" EXACT []
synonym: "downregulation of cGMP catabolic process" EXACT []
synonym: "inhibition of cGMP catabolic process" NARROW []
synonym: "negative regulation of cGMP breakdown" EXACT []
synonym: "negative regulation of cGMP catabolism" EXACT []
synonym: "negative regulation of cGMP degradation" EXACT []
is_a: GO:0030806 ! negative regulation of cyclic nucleotide catabolic process
is_a: GO:0030824 ! negative regulation of cGMP metabolic process
is_a: GO:0030829 ! regulation of cGMP catabolic process
is_a: GO:0033122 ! negative regulation of purine nucleotide catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0046069 ! cGMP catabolic process
relationship: negatively_regulates GO:0046069 ! cGMP catabolic process

[Term]
id: GO:0030831
name: positive regulation of cGMP catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cGMP." [GOC:mah]
subset: gosubset_prok
synonym: "activation of cGMP catabolic process" NARROW []
synonym: "positive regulation of cGMP breakdown" EXACT []
synonym: "positive regulation of cGMP catabolism" EXACT []
synonym: "positive regulation of cGMP degradation" EXACT []
synonym: "stimulation of cGMP catabolic process" NARROW []
synonym: "up regulation of cGMP catabolic process" EXACT []
synonym: "up-regulation of cGMP catabolic process" EXACT []
synonym: "upregulation of cGMP catabolic process" EXACT []
is_a: GO:0030807 ! positive regulation of cyclic nucleotide catabolic process
is_a: GO:0030825 ! positive regulation of cGMP metabolic process
is_a: GO:0030829 ! regulation of cGMP catabolic process
is_a: GO:0033123 ! positive regulation of purine nucleotide catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0046069 ! cGMP catabolic process
relationship: positively_regulates GO:0046069 ! cGMP catabolic process

[Term]
id: GO:0030832
name: regulation of actin filament length
namespace: biological_process
def: "Any process that controls the length of actin filaments in a cell." [GOC:dph, GOC:mah]
comment: Note that the syntax of the definition of the this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process.
is_a: GO:0032535 ! regulation of cellular component size
is_a: GO:0032956 ! regulation of actin cytoskeleton organization

[Term]
id: GO:0030833
name: regulation of actin filament polymerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]
synonym: "regulation of actin polymerization" EXACT []
is_a: GO:0008064 ! regulation of actin polymerization or depolymerization
is_a: GO:0032271 ! regulation of protein polymerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030041 ! actin filament polymerization
relationship: regulates GO:0030041 ! actin filament polymerization

[Term]
id: GO:0030834
name: regulation of actin filament depolymerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the disassembly of actin filaments by the removal of actin monomers from a filament." [GOC:mah]
synonym: "regulation of actin depolymerization" EXACT []
is_a: GO:0008064 ! regulation of actin polymerization or depolymerization
is_a: GO:1901879 ! regulation of protein depolymerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030042 ! actin filament depolymerization
relationship: regulates GO:0030042 ! actin filament depolymerization

[Term]
id: GO:0030835
name: negative regulation of actin filament depolymerization
namespace: biological_process
alt_id: GO:0030044
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of actin depolymerization." [GOC:mah]
comment: Note that this term was split from 'negative regulation of actin polymerization and/or depolymerization ; GO:0045757' (sibling term 'negative regulation of actin polymerization ; GO:0030837').
synonym: "actin filament stabilization" EXACT []
synonym: "down regulation of actin filament depolymerization" EXACT []
synonym: "down-regulation of actin filament depolymerization" EXACT []
synonym: "downregulation of actin filament depolymerization" EXACT []
synonym: "inhibition of actin filament depolymerization" NARROW []
synonym: "negative regulation of actin depolymerization" EXACT []
synonym: "negative regulation of actin polymerization and/or depolymerization" BROAD []
is_a: GO:0030834 ! regulation of actin filament depolymerization
is_a: GO:0051494 ! negative regulation of cytoskeleton organization
is_a: GO:1901880 ! negative regulation of protein depolymerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030042 ! actin filament depolymerization
relationship: negatively_regulates GO:0030042 ! actin filament depolymerization

[Term]
id: GO:0030836
name: positive regulation of actin filament depolymerization
namespace: biological_process
alt_id: GO:0030045
def: "Any process that activates or increases the frequency, rate or extent of actin depolymerization." [GOC:mah]
comment: Note that this term was split from 'positive regulation of actin polymerization and/or depolymerization ; GO:0045758' (sibling term 'positive regulation of actin polymerization ; GO:0030838').
synonym: "actin filament destabilization" EXACT []
synonym: "activation of actin filament depolymerization" NARROW []
synonym: "positive regulation of actin depolymerization" EXACT []
synonym: "positive regulation of actin polymerization and/or depolymerization" BROAD []
synonym: "stimulation of actin filament depolymerization" NARROW []
synonym: "up regulation of actin filament depolymerization" EXACT []
synonym: "up-regulation of actin filament depolymerization" EXACT []
synonym: "upregulation of actin filament depolymerization" EXACT []
is_a: GO:0030834 ! regulation of actin filament depolymerization
is_a: GO:0051495 ! positive regulation of cytoskeleton organization
is_a: GO:1901881 ! positive regulation of protein depolymerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030042 ! actin filament depolymerization
relationship: positively_regulates GO:0030042 ! actin filament depolymerization

[Term]
id: GO:0030837
name: negative regulation of actin filament polymerization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization." [GOC:mah]
comment: Note that this term was split from 'negative regulation of actin polymerization and/or depolymerization ; GO:0045757' (sibling term 'negative regulation of actin depolymerization ; GO:0030835').
synonym: "down regulation of actin filament polymerization" EXACT []
synonym: "down-regulation of actin filament polymerization" EXACT []
synonym: "downregulation of actin filament polymerization" EXACT []
synonym: "inhibition of actin filament polymerization" NARROW []
synonym: "negative regulation of actin polymerization" EXACT []
synonym: "negative regulation of actin polymerization and/or depolymerization" BROAD []
is_a: GO:0030833 ! regulation of actin filament polymerization
is_a: GO:0032272 ! negative regulation of protein polymerization
is_a: GO:0051494 ! negative regulation of cytoskeleton organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030041 ! actin filament polymerization
relationship: negatively_regulates GO:0030041 ! actin filament polymerization

[Term]
id: GO:0030838
name: positive regulation of actin filament polymerization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of actin polymerization." [GOC:mah]
comment: Note that this term was split from 'positive regulation of actin polymerization and/or depolymerization ; GO:0045758' (sibling term 'positive regulation of actin depolymerization ; GO:0030836').
synonym: "activation of actin filament polymerization" NARROW []
synonym: "positive regulation of actin polymerization" EXACT []
synonym: "positive regulation of actin polymerization and/or depolymerization" BROAD []
synonym: "stimulation of actin filament polymerization" NARROW []
synonym: "up regulation of actin filament polymerization" EXACT []
synonym: "up-regulation of actin filament polymerization" EXACT []
synonym: "upregulation of actin filament polymerization" EXACT []
is_a: GO:0030833 ! regulation of actin filament polymerization
is_a: GO:0032273 ! positive regulation of protein polymerization
is_a: GO:0051495 ! positive regulation of cytoskeleton organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030041 ! actin filament polymerization
relationship: positively_regulates GO:0030041 ! actin filament polymerization

[Term]
id: GO:0030839
name: regulation of intermediate filament polymerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the assembly of intermediate filaments by the addition of monomers to a filament." [GOC:mah]
is_a: GO:0032271 ! regulation of protein polymerization
is_a: GO:0045108 ! regulation of intermediate filament polymerization or depolymerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045107 ! intermediate filament polymerization
relationship: regulates GO:0045107 ! intermediate filament polymerization

[Term]
id: GO:0030840
name: negative regulation of intermediate filament polymerization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of intermediate filament polymerization." [GOC:mah]
comment: Note that this term was split from 'negative regulation of intermediate filament polymerization and/or depolymerization ; GO:0045825' (sibling term 'negative regulation of intermediate filament depolymerization ; GO:0030843').
synonym: "down regulation of intermediate filament polymerization" EXACT []
synonym: "down-regulation of intermediate filament polymerization" EXACT []
synonym: "downregulation of intermediate filament polymerization" EXACT []
synonym: "inhibition of intermediate filament polymerization" NARROW []
synonym: "negative regulation of intermediate filament polymerization and/or depolymerization" BROAD []
is_a: GO:0030839 ! regulation of intermediate filament polymerization
is_a: GO:0032272 ! negative regulation of protein polymerization
is_a: GO:0051494 ! negative regulation of cytoskeleton organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045107 ! intermediate filament polymerization
relationship: negatively_regulates GO:0045107 ! intermediate filament polymerization

[Term]
id: GO:0030841
name: positive regulation of intermediate filament polymerization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of intermediate filament polymerization." [GOC:mah]
comment: Note that this term was split from 'positive regulation of intermediate filament polymerization and/or depolymerization ; GO:0045826' (sibling term 'positive regulation of intermediate filament depolymerization ; GO:0030844').
synonym: "activation of intermediate filament polymerization" NARROW []
synonym: "positive regulation of intermediate filament polymerization and/or depolymerization" BROAD []
synonym: "stimulation of intermediate filament polymerization" NARROW []
synonym: "up regulation of intermediate filament polymerization" EXACT []
synonym: "up-regulation of intermediate filament polymerization" EXACT []
synonym: "upregulation of intermediate filament polymerization" EXACT []
is_a: GO:0030839 ! regulation of intermediate filament polymerization
is_a: GO:0032273 ! positive regulation of protein polymerization
is_a: GO:0051495 ! positive regulation of cytoskeleton organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045107 ! intermediate filament polymerization
relationship: positively_regulates GO:0045107 ! intermediate filament polymerization

[Term]
id: GO:0030842
name: regulation of intermediate filament depolymerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the disassembly of intermediate filaments by the removal of monomers from a filament." [GOC:mah]
is_a: GO:0045108 ! regulation of intermediate filament polymerization or depolymerization
is_a: GO:1901879 ! regulation of protein depolymerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045106 ! intermediate filament depolymerization
relationship: regulates GO:0045106 ! intermediate filament depolymerization

[Term]
id: GO:0030843
name: negative regulation of intermediate filament depolymerization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of intermediate filament depolymerization." [GOC:mah]
comment: Note that this term was split from 'negative regulation of intermediate filament polymerization and/or depolymerization ; GO:0045825' (sibling term 'negative regulation of intermediate filament polymerization ; GO:0030840').
synonym: "down regulation of intermediate filament depolymerization" EXACT []
synonym: "down-regulation of intermediate filament depolymerization" EXACT []
synonym: "downregulation of intermediate filament depolymerization" EXACT []
synonym: "inhibition of intermediate filament depolymerization" NARROW []
synonym: "negative regulation of intermediate filament polymerization and/or depolymerization" BROAD []
is_a: GO:0030842 ! regulation of intermediate filament depolymerization
is_a: GO:0051494 ! negative regulation of cytoskeleton organization
is_a: GO:1901880 ! negative regulation of protein depolymerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045106 ! intermediate filament depolymerization
relationship: negatively_regulates GO:0045106 ! intermediate filament depolymerization

[Term]
id: GO:0030844
name: positive regulation of intermediate filament depolymerization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of intermediate filament depolymerization." [GOC:mah]
comment: Note that this term was split from 'positive regulation of intermediate filament polymerization and/or depolymerization ; GO:0045826' (sibling term 'positive regulation of intermediate filament polymerization ; GO:0030841').
synonym: "activation of intermediate filament depolymerization" NARROW []
synonym: "positive regulation of intermediate filament polymerization and/or depolymerization" BROAD []
synonym: "stimulation of intermediate filament depolymerization" NARROW []
synonym: "up regulation of intermediate filament depolymerization" EXACT []
synonym: "up-regulation of intermediate filament depolymerization" EXACT []
synonym: "upregulation of intermediate filament depolymerization" EXACT []
is_a: GO:0030842 ! regulation of intermediate filament depolymerization
is_a: GO:0051495 ! positive regulation of cytoskeleton organization
is_a: GO:1901881 ! positive regulation of protein depolymerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045106 ! intermediate filament depolymerization
relationship: positively_regulates GO:0045106 ! intermediate filament depolymerization

[Term]
id: GO:0030845
name: phospholipase C-inhibiting G-protein coupled receptor signaling pathway
namespace: biological_process
def: "A G-protein coupled receptor signaling pathway which proceeds with inhibition of phospholipase C (PLC) activity and a subsequent decrease in the levels of cellular inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, PMID:8280098]
comment: This term is intended to cover steps in a GPCR signaling pathway both upstream and downstream of phospholipase C (PLC) inhibition.
synonym: "G-protein-coupled inhibitory pathway of phospholipase C" EXACT [PMID:8280098]
synonym: "GPCR signaling pathway coupled to inhibition of phospholipase C activity" EXACT [GOC:signaling]
synonym: "GPCR signaling pathway via inhibition of PLC" EXACT [GOC:signaling]
synonym: "inhibition of phospholipase C activity involved in G-protein coupled receptor signalling pathway" NARROW [GOC:mah]
synonym: "phospholipase C inhibition" RELATED [GOC:dph, GOC:tb]
synonym: "PLC-inhibiting GPCR signaling pathway" EXACT [GOC:signaling]
is_a: GO:0007186 ! G-protein coupled receptor signaling pathway
relationship: has_part GO:1900275 ! negative regulation of phospholipase C activity

[Term]
id: GO:0030846
name: termination of RNA polymerase II transcription, poly(A)-coupled
namespace: biological_process
def: "The process in which transcription of polyadenylated RNA polymerase II transcripts is terminated; cleavage and polyadenylylation of the mRNA 3' end is coupled to transcription termination." [GOC:txnOH, PMID:12944462, PMID:18679429]
synonym: "termination of RNA polymerase II transcription, polyadenylation-coupled" RELATED []
synonym: "transcription termination from Pol II promoter, poly(A) coupled" RELATED []
synonym: "transcription termination from Pol II promoter, RNA polymerase(A) coupled" RELATED []
is_a: GO:0006369 ! termination of RNA polymerase II transcription

[Term]
id: GO:0030847
name: termination of RNA polymerase II transcription, exosome-dependent
namespace: biological_process
def: "The process in which transcription of nonpolyadenylated RNA polymerase II transcripts is terminated; coupled to the maturation of the RNA 3'-end." [GOC:txnOH, PMID:12944462, PMID:18679429]
synonym: "termination of RNA polymerase II transcription, poly(A)-independent" EXACT []
synonym: "transcription termination from Pol II promoter, poly(A)-independent" EXACT []
synonym: "transcription termination from Pol II promoter, RNA polymerase(A)-independent" EXACT []
is_a: GO:0006369 ! termination of RNA polymerase II transcription

[Term]
id: GO:0030848
name: threo-3-hydroxyaspartate ammonia-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3S)-3-hydroxy-L-aspartate = NH(4)(+) + oxaloacetate." [EC:4.3.1.16, RHEA:12427]
synonym: "3-hydroxyaspartate dehydratase activity" BROAD [GOC:mcc, PMID:10481099]
synonym: "L-threo-3-hydroxyaspartate dehydratase activity" EXACT [EC:4.3.1.16]
synonym: "threo-3-hydroxy-L-aspartate ammonia-lyase (oxaloacetate-forming)" EXACT [EC:4.3.1.16]
synonym: "threo-3-hydroxy-L-aspartate ammonia-lyase activity" EXACT [EC:4.3.1.16]
synonym: "threo-3-hydroxyaspartate dehydratase activity" EXACT [EC:4.3.1.16]
xref: EC:4.3.1.16
xref: KEGG:R05758
xref: MetaCyc:4.3.1.16-RXN
xref: RHEA:12427
is_a: GO:0016841 ! ammonia-lyase activity

[Term]
id: GO:0030849
name: autosome
namespace: cellular_component
def: "Any chromosome other than a sex chromosome." [GOC:mah]
comment: Note that this term is mainly relevant in organisms that have both sex chromosomes and non-sex-determining chromosomes in an individual organism.
xref: Wikipedia:Autosome
is_a: GO:0005694 ! chromosome

[Term]
id: GO:0030850
name: prostate gland development
namespace: biological_process
def: "The process whose specific outcome is the progression of the prostate gland over time, from its formation to the mature structure. The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid." [PMID:11839751]
synonym: "prostate development" EXACT []
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0048608 ! reproductive structure development
is_a: GO:0048732 ! gland development
relationship: part_of GO:0001655 ! urogenital system development

[Term]
id: GO:0030851
name: granulocyte differentiation
namespace: biological_process
def: "The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils." [GOC:ecd, http://life.nthu.edu.tw/~g864204/dict-search1.htm]
synonym: "granulocyte cell differentiation" EXACT []
is_a: GO:0002573 ! myeloid leukocyte differentiation

[Term]
id: GO:0030852
name: regulation of granulocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of granulocyte differentiation." [GOC:mah]
is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030851 ! granulocyte differentiation
relationship: regulates GO:0030851 ! granulocyte differentiation

[Term]
id: GO:0030853
name: negative regulation of granulocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of granulocyte differentiation." [GOC:mah]
synonym: "down regulation of granulocyte differentiation" EXACT []
synonym: "down-regulation of granulocyte differentiation" EXACT []
synonym: "downregulation of granulocyte differentiation" EXACT []
synonym: "inhibition of granulocyte differentiation" NARROW []
is_a: GO:0002762 ! negative regulation of myeloid leukocyte differentiation
is_a: GO:0030852 ! regulation of granulocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030851 ! granulocyte differentiation
relationship: negatively_regulates GO:0030851 ! granulocyte differentiation

[Term]
id: GO:0030854
name: positive regulation of granulocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of granulocyte differentiation." [GOC:mah]
synonym: "activation of granulocyte differentiation" NARROW []
synonym: "stimulation of granulocyte differentiation" NARROW []
synonym: "up regulation of granulocyte differentiation" EXACT []
synonym: "up-regulation of granulocyte differentiation" EXACT []
synonym: "upregulation of granulocyte differentiation" EXACT []
is_a: GO:0002763 ! positive regulation of myeloid leukocyte differentiation
is_a: GO:0030852 ! regulation of granulocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030851 ! granulocyte differentiation
relationship: positively_regulates GO:0030851 ! granulocyte differentiation

[Term]
id: GO:0030855
name: epithelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium." [GOC:ecd, PMID:11839751]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0060429 ! epithelium development

[Term]
id: GO:0030856
name: regulation of epithelial cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of epithelial cell differentiation." [GOC:mah]
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030855 ! epithelial cell differentiation
relationship: regulates GO:0030855 ! epithelial cell differentiation

[Term]
id: GO:0030857
name: negative regulation of epithelial cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation." [GOC:mah]
synonym: "down regulation of epithelial cell differentiation" EXACT []
synonym: "down-regulation of epithelial cell differentiation" EXACT []
synonym: "downregulation of epithelial cell differentiation" EXACT []
synonym: "inhibition of epithelial cell differentiation" NARROW []
is_a: GO:0030856 ! regulation of epithelial cell differentiation
is_a: GO:0045596 ! negative regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030855 ! epithelial cell differentiation
relationship: negatively_regulates GO:0030855 ! epithelial cell differentiation

[Term]
id: GO:0030858
name: positive regulation of epithelial cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation." [GOC:mah]
synonym: "activation of epithelial cell differentiation" NARROW []
synonym: "stimulation of epithelial cell differentiation" NARROW []
synonym: "up regulation of epithelial cell differentiation" EXACT []
synonym: "up-regulation of epithelial cell differentiation" EXACT []
synonym: "upregulation of epithelial cell differentiation" EXACT []
is_a: GO:0030856 ! regulation of epithelial cell differentiation
is_a: GO:0045597 ! positive regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030855 ! epithelial cell differentiation
relationship: positively_regulates GO:0030855 ! epithelial cell differentiation

[Term]
id: GO:0030859
name: polarized epithelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a polarized epithelial cell. The polarized epithelial cell can be any of the cells within an epithelium where the epithelial sheet is oriented with respect to the planar axis." [GOC:mah]
is_a: GO:0030855 ! epithelial cell differentiation
relationship: part_of GO:0001738 ! morphogenesis of a polarized epithelium

[Term]
id: GO:0030860
name: regulation of polarized epithelial cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of polarized epithelial cell differentiation." [GOC:mah]
is_a: GO:0030856 ! regulation of epithelial cell differentiation
is_a: GO:2000027 ! regulation of organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030859 ! polarized epithelial cell differentiation
relationship: regulates GO:0030859 ! polarized epithelial cell differentiation

[Term]
id: GO:0030861
name: negative regulation of polarized epithelial cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of polarized epithelial cell differentiation." [GOC:mah]
synonym: "down regulation of polarized epithelial cell differentiation" EXACT []
synonym: "down-regulation of polarized epithelial cell differentiation" EXACT []
synonym: "downregulation of polarized epithelial cell differentiation" EXACT []
synonym: "inhibition of polarized epithelial cell differentiation" NARROW []
is_a: GO:0030857 ! negative regulation of epithelial cell differentiation
is_a: GO:0030860 ! regulation of polarized epithelial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030859 ! polarized epithelial cell differentiation
relationship: negatively_regulates GO:0030859 ! polarized epithelial cell differentiation

[Term]
id: GO:0030862
name: positive regulation of polarized epithelial cell differentiation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of polarized epithelial cell differentiation." [GOC:mah]
synonym: "activation of polarized epithelial cell differentiation" NARROW []
synonym: "stimulation of polarized epithelial cell differentiation" NARROW []
synonym: "up regulation of polarized epithelial cell differentiation" EXACT []
synonym: "up-regulation of polarized epithelial cell differentiation" EXACT []
synonym: "upregulation of polarized epithelial cell differentiation" EXACT []
is_a: GO:0030858 ! positive regulation of epithelial cell differentiation
is_a: GO:0030860 ! regulation of polarized epithelial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030859 ! polarized epithelial cell differentiation
relationship: positively_regulates GO:0030859 ! polarized epithelial cell differentiation

[Term]
id: GO:0030863
name: cortical cytoskeleton
namespace: cellular_component
def: "The portion of the cytoskeleton that lies just beneath the plasma membrane." [GOC:mah]
is_a: GO:0005856 ! cytoskeleton
is_a: GO:0044448 ! cell cortex part

[Term]
id: GO:0030864
name: cortical actin cytoskeleton
namespace: cellular_component
def: "The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane." [GOC:mah]
is_a: GO:0030863 ! cortical cytoskeleton
is_a: GO:0044430 ! cytoskeletal part
intersection_of: GO:0030863 ! cortical cytoskeleton
intersection_of: part_of GO:0015629 ! actin cytoskeleton
relationship: part_of GO:0015629 ! actin cytoskeleton

[Term]
id: GO:0030865
name: cortical cytoskeleton organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]
synonym: "cortical cytoskeleton organisation" EXACT [GOC:curators]
synonym: "cortical cytoskeleton organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0007010 ! cytoskeleton organization

[Term]
id: GO:0030866
name: cortical actin cytoskeleton organization
namespace: biological_process
alt_id: GO:0033109
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah, GOC:pf]
synonym: "actin cortex stabilization" EXACT []
synonym: "cortical actin cytoskeleton organisation" EXACT [GOC:curators]
synonym: "cortical actin cytoskeleton organization and biogenesis" RELATED [GOC:mah]
synonym: "cortical actin cytoskeleton stabilization" EXACT []
synonym: "cortical resistance" RELATED []
is_a: GO:0030036 ! actin cytoskeleton organization
is_a: GO:0030865 ! cortical cytoskeleton organization

[Term]
id: GO:0030867
name: rough endoplasmic reticulum membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the rough endoplasmic reticulum." [GOC:mah]
synonym: "RER membrane" EXACT [NIF_Subcellular:sao3089754107]
synonym: "rough ER membrane" EXACT []
xref: NIF_Subcellular:sao3089754107
is_a: GO:0005789 ! endoplasmic reticulum membrane
relationship: part_of GO:0005791 ! rough endoplasmic reticulum

[Term]
id: GO:0030868
name: smooth endoplasmic reticulum membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the smooth endoplasmic reticulum." [GOC:mah]
synonym: "SER membrane" EXACT []
synonym: "smooth ER membrane" EXACT []
xref: NIF_Subcellular:sao1596955044
is_a: GO:0005789 ! endoplasmic reticulum membrane
is_a: GO:0097425 ! smooth endoplasmic reticulum part
relationship: part_of GO:0005790 ! smooth endoplasmic reticulum

[Term]
id: GO:0030869
name: RENT complex
namespace: cellular_component
def: "A protein complex that mediates transcriptional silencing at the rDNA locus (the name derives from regulator of nucleolar silencing and telophase). In Saccharomyces the complex contains Net1p, Sir2p, Cdc14p, and at least one more subunit." [PMID:12196389]
is_a: GO:0005677 ! chromatin silencing complex
is_a: GO:0044452 ! nucleolar part

[Term]
id: GO:0030870
name: Mre11 complex
namespace: cellular_component
def: "Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins." [GOC:mah, GOC:vw, PMID:11988766, PMID:17674145]
synonym: "MRN complex" EXACT []
synonym: "MRX complex" EXACT []
synonym: "Rad50 complex" EXACT []
synonym: "RAD50-MRE11-NBN complex" EXACT [CORUM:2767]
synonym: "Rad50-Rad32-Nbs1 complex" EXACT []
synonym: "RMX complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0030874
name: nucleolar chromatin
namespace: cellular_component
def: "The portion of nuclear chromatin associated with the nucleolus; includes the DNA encoding the ribosomal RNA." [GOC:mah]
is_a: GO:0044452 ! nucleolar part
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000790 ! nuclear chromatin

[Term]
id: GO:0030875
name: rDNA protrusion
namespace: cellular_component
def: "Any of the tandem arrays of rDNA localized at the periphery of the nucleus and protruding into the nucleolus, and associated proteins. May be visible as a single or double spot by DAPI staining." [PMID:1629244]
comment: Note that this component is characterized in Schizosaccharomyces, particularly with respect to the DAPI staining pattern.
synonym: "ribosomal DNA protrusion" EXACT []
is_a: GO:0044452 ! nucleolar part
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0030874 ! nucleolar chromatin

[Term]
id: GO:0030876
name: interleukin-20 receptor complex
namespace: cellular_component
def: "A protein complex that binds interleukin-20; comprises an alpha and a beta subunit." [GOC:mah]
synonym: "IL-20 receptor complex" EXACT [GOC:add]
is_a: GO:0098802 ! plasma membrane receptor complex
relationship: part_of GO:0005887 ! integral component of plasma membrane

[Term]
id: GO:0030877
name: beta-catenin destruction complex
namespace: cellular_component
alt_id: GO:0034742
alt_id: GO:0034747
def: "A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome." [PMID:14600025]
comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
synonym: "23S APC complex" NARROW []
synonym: "APC-Axin-1-beta-catenin complex" EXACT []
synonym: "Axin-APC-beta-catenin-GSK3B complex" EXACT []
synonym: "BDC" EXACT [GOC:bf, GOC:PARL, PMID:22899650]
synonym: "beta-catenin degradation complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0030878
name: thyroid gland development
namespace: biological_process
def: "The process whose specific outcome is the progression of the thyroid gland over time, from its formation to the mature structure. The thyroid gland is an endoderm-derived gland that produces thyroid hormone." [GOC:dgh]
is_a: GO:0048732 ! gland development
relationship: part_of GO:0035270 ! endocrine system development

[Term]
id: GO:0030879
name: mammary gland development
namespace: biological_process
def: "The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages." [PMID:9576833]
synonym: "mammogenesis" NARROW [GOC:dph]
is_a: GO:0048732 ! gland development

[Term]
id: GO:0030880
name: RNA polymerase complex
namespace: cellular_component
def: "Any complex that possesses RNA polymerase activity; generally comprises a catalytic subunit and one or more additional subunits." [GOC:mah]
subset: goslim_pir
subset: gosubset_prok
synonym: "multisubunit RNA polymerase" EXACT []
is_a: GO:0044424 ! intracellular part
is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups

[Term]
id: GO:0030881
name: beta-2-microglobulin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with beta-2-microglobulin." [GOC:mah]
subset: goslim_chembl
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0030882
name: lipid antigen binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a lipid antigen." [PMID:14500461]
is_a: GO:0003823 ! antigen binding
is_a: GO:0008289 ! lipid binding

[Term]
id: GO:0030883
name: endogenous lipid antigen binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an endogenous cellular lipid antigen." [PMID:14500461]
is_a: GO:0030882 ! lipid antigen binding

[Term]
id: GO:0030884
name: exogenous lipid antigen binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an exogenous lipid antigen (examples include microbial lipids and glycolipids)." [PMID:14500461]
is_a: GO:0030882 ! lipid antigen binding

[Term]
id: GO:0030885
name: regulation of myeloid dendritic cell activation
namespace: biological_process
def: "Any process that modulates the frequency or rate of myeloid dendritic cell activation." [GOC:mah]
is_a: GO:0002694 ! regulation of leukocyte activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001773 ! myeloid dendritic cell activation
relationship: regulates GO:0001773 ! myeloid dendritic cell activation

[Term]
id: GO:0030886
name: negative regulation of myeloid dendritic cell activation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid dendritic cell activation." [GOC:mah]
synonym: "down regulation of myeloid dendritic cell activation" EXACT []
synonym: "down-regulation of myeloid dendritic cell activation" EXACT []
synonym: "downregulation of myeloid dendritic cell activation" EXACT []
synonym: "inhibition of myeloid dendritic cell activation" NARROW []
is_a: GO:0002695 ! negative regulation of leukocyte activation
is_a: GO:0030885 ! regulation of myeloid dendritic cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001773 ! myeloid dendritic cell activation
relationship: negatively_regulates GO:0001773 ! myeloid dendritic cell activation

[Term]
id: GO:0030887
name: positive regulation of myeloid dendritic cell activation
namespace: biological_process
def: "Any process that stimulates, induces or increases the rate of myeloid dendritic cell activation." [GOC:mah]
synonym: "activation of myeloid dendritic cell activation" NARROW []
synonym: "stimulation of myeloid dendritic cell activation" NARROW []
synonym: "up regulation of myeloid dendritic cell activation" EXACT []
synonym: "up-regulation of myeloid dendritic cell activation" EXACT []
synonym: "upregulation of myeloid dendritic cell activation" EXACT []
is_a: GO:0002696 ! positive regulation of leukocyte activation
is_a: GO:0030885 ! regulation of myeloid dendritic cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001773 ! myeloid dendritic cell activation
relationship: positively_regulates GO:0001773 ! myeloid dendritic cell activation

[Term]
id: GO:0030888
name: regulation of B cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of B cell proliferation." [GOC:mah]
synonym: "regulation of B lymphocyte proliferation" EXACT []
synonym: "regulation of B-cell proliferation" EXACT []
synonym: "regulation of B-lymphocyte proliferation" EXACT []
is_a: GO:0050670 ! regulation of lymphocyte proliferation
is_a: GO:0050864 ! regulation of B cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042100 ! B cell proliferation
relationship: regulates GO:0042100 ! B cell proliferation

[Term]
id: GO:0030889
name: negative regulation of B cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of B cell proliferation." [GOC:mah]
synonym: "down regulation of B cell proliferation" EXACT []
synonym: "down-regulation of B cell proliferation" EXACT []
synonym: "downregulation of B cell proliferation" EXACT []
synonym: "inhibition of B cell proliferation" NARROW []
synonym: "negative regulation of B lymphocyte proliferation" EXACT []
synonym: "negative regulation of B-cell proliferation" EXACT []
synonym: "negative regulation of B-lymphocyte proliferation" EXACT []
is_a: GO:0030888 ! regulation of B cell proliferation
is_a: GO:0050672 ! negative regulation of lymphocyte proliferation
is_a: GO:0050869 ! negative regulation of B cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042100 ! B cell proliferation
relationship: negatively_regulates GO:0042100 ! B cell proliferation

[Term]
id: GO:0030890
name: positive regulation of B cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of B cell proliferation." [GOC:mah]
synonym: "activation of B cell proliferation" NARROW []
synonym: "positive regulation of B lymphocyte proliferation" EXACT []
synonym: "positive regulation of B-cell proliferation" EXACT []
synonym: "positive regulation of B-lymphocyte proliferation" EXACT []
synonym: "stimulation of B cell proliferation" NARROW []
synonym: "up regulation of B cell proliferation" EXACT []
synonym: "up-regulation of B cell proliferation" EXACT []
synonym: "upregulation of B cell proliferation" EXACT []
is_a: GO:0030888 ! regulation of B cell proliferation
is_a: GO:0050671 ! positive regulation of lymphocyte proliferation
is_a: GO:0050871 ! positive regulation of B cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042100 ! B cell proliferation
relationship: positively_regulates GO:0042100 ! B cell proliferation

[Term]
id: GO:0030891
name: VCB complex
namespace: cellular_component
def: "A protein complex that possesses ubiquitin ligase activity; the complex is usually pentameric; for example, in mammals the subunits are pVHL, elongin B, elongin C, cullin-2 (Cul2), and Rbx1." [GOC:mah, PMID:11865071]
synonym: "pVHL-elongin C-elongin B complex" EXACT []
synonym: "VHL complex" EXACT []
synonym: "von Hippel-Lindau tumor suppressor complex" EXACT []
is_a: GO:0000153 ! cytoplasmic ubiquitin ligase complex

[Term]
id: GO:0030892
name: mitotic cohesin complex
namespace: cellular_component
def: "A cohesin complex that mediates sister chromatid cohesion during mitosis; has a subunit composition distinct from that of the meiotic cohesin complex." [GOC:mah, PMID:12750522]
is_a: GO:0008278 ! cohesin complex

[Term]
id: GO:0030893
name: meiotic cohesin complex
namespace: cellular_component
def: "A cohesin complex that mediates sister chromatid cohesion during meiosis; has a subunit composition distinct from that of the mitotic cohesin complex." [GOC:mah, PMID:12750522]
is_a: GO:0008278 ! cohesin complex

[Term]
id: GO:0030894
name: replisome
namespace: cellular_component
def: "A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins." [GOC:mah, GOC:vw]
subset: goslim_pir
subset: gosubset_prok
synonym: "DNA synthesome complex" RELATED [CORUM:1001]
synonym: "RC complex" RELATED [CORUM:309, PMID:12006500]
synonym: "replication-competent complex" RELATED [CORUM:309, PMID:12006500]
xref: Wikipedia:Replisome
is_a: GO:0032993 ! protein-DNA complex
is_a: GO:0044427 ! chromosomal part
relationship: has_part GO:0033202 ! DNA helicase complex
relationship: has_part GO:0042575 ! DNA polymerase complex
relationship: part_of GO:0005657 ! replication fork

[Term]
id: GO:0030895
name: apolipoprotein B mRNA editing enzyme complex
namespace: cellular_component
def: "Protein complex that mediates editing of the mRNA encoding apolipoprotein B; catalyzes the deamination of C to U (residue 6666 in the human mRNA). Contains a catalytic subunit, APOBEC-1, and other proteins (e.g. human ASP; rat ASP and KSRP)." [PMID:10781591]
synonym: "apoB mRNA editing enzyme complex" EXACT []
synonym: "APOBEC" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0030896
name: checkpoint clamp complex
namespace: cellular_component
def: "Conserved heterotrimeric complex of PCNA-like proteins that is loaded onto DNA at sites of DNA damage." [PMID:12531008]
comment: Note that the following subunit names have been used: human RAD9/RAD1/HUS1; S. pombe Rad9/Rad1/Hus1; S. cerevisiae Ddc1p/Rad17p/Mec3p.
synonym: "CCC" EXACT []
synonym: "Rad9-Hus1-Rad1 (9-1-1) clamp complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000794 ! condensed nuclear chromosome

[Term]
id: GO:0030897
name: HOPS complex
namespace: cellular_component
def: "A multimeric protein complex that associates with the vacuolar membrane, late endosomal (multivesicular body) and lysosomal membranes. HOPS is a tethering complex involved in vesicle fusion." [PMID:10944212, PMID:23645161]
is_a: GO:0098796 ! membrane protein complex

[Term]
id: GO:0030898
name: actin-dependent ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of an actin filament to accelerate release of ADP and phosphate." [GOC:mah]
synonym: "actin-activated ATPase activity" EXACT []
is_a: GO:0042623 ! ATPase activity, coupled

[Term]
id: GO:0030899
name: calcium-dependent ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of calcium ion (Ca2+)." [GOC:mah]
is_a: GO:0042623 ! ATPase activity, coupled

[Term]
id: GO:0030900
name: forebrain development
namespace: biological_process
def: "The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)." [http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=forebrain]
synonym: "prosencephalon development" EXACT []
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007420 ! brain development

[Term]
id: GO:0030901
name: midbrain development
namespace: biological_process
def: "The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles)." [http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=midbrain]
synonym: "mesencephalon development" EXACT []
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007420 ! brain development

[Term]
id: GO:0030902
name: hindbrain development
namespace: biological_process
def: "The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium)." [http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=hindbrain]
synonym: "rhombencephalon development" EXACT []
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007420 ! brain development

[Term]
id: GO:0030903
name: notochord development
namespace: biological_process
def: "The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column." [GOC:dgh]
is_a: GO:0048568 ! embryonic organ development

[Term]
id: GO:0030904
name: retromer complex
namespace: cellular_component
def: "A conserved hetero-pentameric membrane-associated complex involved in retrograde transport from endosomes to the Golgi apparatus. The budding yeast retromer comprises Vps35p, Vps29p, Vps26p, Vps5p, and Vps17p. The mammalian complex shows slight variation in composition compared to yeast, and comprises SNX1 or SNX2, SNX5 or SNX6, VPS26A or VPS26B, VPS29, and VPS35." [GOC:bf, PMID:26220253, PMID:9700157]
subset: goslim_pir
is_a: GO:0044464 ! cell part
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0012505 ! endomembrane system

[Term]
id: GO:0030905
name: retromer, tubulation complex
namespace: cellular_component
def: "The dimeric subcomplex of the retromer, believed to be peripherally associated with the membrane. This dimeric complex is responsible for remodelling endosomal membranes to form a tube-structure to which cargo molecules are selected for recycling. The budding yeast complex comprises Vps5p and Vps17p, and may contain multiple copies of a Vps5p/Vps17p dimer. The mammalian complex contains SNX1 or SNX2 dimerized with SNX5 or SNX6." [GOC:bf, PMID:26220253, PMID:9700157]
synonym: "heterodimeric membrane-deforming retromer subcomplex" EXACT [GOC:bf, GOC:PARL, PMID:22193161]
synonym: "retromer complex, outer shell" EXACT []
synonym: "SNX-BAR dimer" EXACT [PMID:26220253]
is_a: GO:0044464 ! cell part
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0030904 ! retromer complex

[Term]
id: GO:0030906
name: retromer, cargo-selective complex
namespace: cellular_component
def: "The trimeric subcomplex of the retromer, believed to be closely associated with the membrane. This trimeric complex is responsible for recognizing and binding to cargo molecules. The complex comprises three Vps proteins in both yeast and mammalian cells: Vps35p, Vps29p, and Vps26p in yeast, and VPS35, VPS29 and VPS26A or VPS26B in mammals." [GOC:bf, PMID:11102511, PMID:26220253, PMID:9700157]
synonym: "cargo-selective retromer subcomplex" EXACT [PMID:19531583, PMID:20923837]
synonym: "retromer complex, inner shell" EXACT []
synonym: "retromer CSC" EXACT [GOC:bf, GOC:PARL]
synonym: "retromer, cargo recognition complex" EXACT [PMID:26220253]
synonym: "retromer, CRC" EXACT [GOC:bf, GOC:PARL, PMID:26220253]
is_a: GO:0044464 ! cell part
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0030904 ! retromer complex

[Term]
id: GO:0030907
name: MBF transcription complex
namespace: cellular_component
def: "A protein complex that binds to the Mlu1 cell cycle box (MCB) promoter element, consensus sequence ACGCGN, and is involved in regulation of transcription during the G1/S transition of the cell cycle. In Saccharomyces, the complex contains a heterodimer of the DNA binding protein Mbp1p and the activator Swi4p, and is associated with additional proteins known as Nrm1p, Msa1p, and Msa2p; in Schizosaccharomyces the complex contains Res1p, Res2p, and Cdc10p." [GOC:mah, PMID:11206552, PMID:15838511, PMID:18160399, PMID:9343385]
synonym: "DSC1 transcription factor complex" EXACT []
synonym: "MBF" EXACT []
synonym: "Mlu1-box binding factor" EXACT []
is_a: GO:0090575 ! RNA polymerase II transcription factor complex

[Term]
id: GO:0030908
name: protein splicing
namespace: biological_process
def: "The post-translational removal of peptide sequences from within a protein sequence." [GOC:mah]
subset: gosubset_prok
xref: Wikipedia:Protein_splicing
is_a: GO:0016485 ! protein processing

[Term]
id: GO:0030909
name: non-intein-mediated protein splicing
namespace: biological_process
def: "The post-translational removal of peptide sequences from within a protein sequence, by a process not involving inteins." [GOC:mah]
subset: gosubset_prok
is_a: GO:0030908 ! protein splicing

[Term]
id: GO:0030910
name: olfactory placode formation
namespace: biological_process
def: "The formation of a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity." [GOC:dgh]
is_a: GO:0060788 ! ectodermal placode formation
relationship: part_of GO:0043584 ! nose development
relationship: part_of GO:0071699 ! olfactory placode morphogenesis

[Term]
id: GO:0030911
name: TPR domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a tetratricopeptide repeat (TPR) domain of a protein, the consensus sequence of which is defined by a pattern of small and large hydrophobic amino acids and a structure composed of helices." [GOC:mah]
synonym: "tetratricopeptide repeat domain binding" EXACT [GOC:sl]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0030912
name: response to deep water
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a deep water stimulus, being immersed in standing deep water throughout the life cycle." [GOC:mah]
comment: Note that this term should not be confused with 'response to flooding ; GO:0009413'; which refers to immersion in water on a shorter time scale.
is_a: GO:0009415 ! response to water

[Term]
id: GO:0030913
name: paranodal junction assembly
namespace: biological_process
def: "Formation of the junction between an axon and the glial cell that forms the myelin sheath. Paranodal junctions form at each paranode, i.e. at the ends of the unmyelinated nodes of Ranvier." [PMID:14715942]
synonym: "paranodal axoglial junction formation" EXACT [PMID:18803321]
synonym: "paranodal junction biosynthesis" EXACT []
synonym: "paranodal junction formation" EXACT []
is_a: GO:0007043 ! cell-cell junction assembly
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
relationship: part_of GO:0032288 ! myelin assembly

[Term]
id: GO:0030914
name: STAGA complex
namespace: cellular_component
def: "A large multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. The composition is similar to that of the SAGA complex; for example, the human complex contains the transcription-transformation cofactor TRRAP, hGCN5L acetylase, novel human ADA-like and SPT-like cofactors, and a subset of TAFs." [PMID:11564863]
comment: See also the cellular component term 'SAGA complex ; GO:0000124'.
synonym: "SPT3-TAF9-GCN5 acetylase complex" EXACT [GOC:rl, PMID:18838386]
synonym: "STAGA coactivator complex" EXACT []
is_a: GO:0070461 ! SAGA-type complex

[Term]
id: GO:0030915
name: Smc5-Smc6 complex
namespace: cellular_component
def: "A conserved complex that contains a heterodimer of SMC proteins (Smc5p and Smc6p, or homologs thereof) and several other proteins, and is involved in DNA repair and maintaining cell cycle arrest following DNA damage. In S. cerevisiae, this is an octameric complex called Mms21-Smc5-Smc6 complex, with at least five of its subunits conserved in fission yeast and humans." [GOC:rb, PMID:14701739]
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000793 ! condensed chromosome

[Term]
id: GO:0030916
name: otic vesicle formation
namespace: biological_process
def: "The process resulting in the transition of the otic placode into the otic vesicle, a transient embryonic structure formed during development of the vertebrate inner ear." [GOC:dgh]
synonym: "otocyst biosynthesis" EXACT []
synonym: "otocyst formation" EXACT []
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0071600 ! otic vesicle morphogenesis

[Term]
id: GO:0030917
name: midbrain-hindbrain boundary development
namespace: biological_process
def: "The process whose specific outcome is the progression of the midbrain-hindbrain boundary over time, from its formation to the mature structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages." [GOC:dgh]
synonym: "isthmic organizer development" EXACT []
synonym: "isthmomesencephalic boundary development" EXACT []
synonym: "isthmus development" EXACT []
synonym: "MHB development" EXACT []
synonym: "midbrain-hindbrain orgainizer development" EXACT []
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007420 ! brain development
relationship: part_of GO:0021903 ! rostrocaudal neural tube patterning

[Term]
id: GO:0030919
name: peptidyl-serine O-acetylation
namespace: biological_process
def: "The acetylation of peptidyl-serine to form peptidyl-O-acetyl-L-serine." [PMID:489587, PMID:7309355, RESID:AA0364]
subset: gosubset_prok
xref: RESID:AA0364
is_a: GO:0018209 ! peptidyl-serine modification
is_a: GO:0030920 ! peptidyl-serine acetylation

[Term]
id: GO:0030920
name: peptidyl-serine acetylation
namespace: biological_process
def: "The acetylation of peptidyl-serine." [GOC:mah]
subset: gosubset_prok
is_a: GO:0006473 ! protein acetylation

[Term]
id: GO:0030921
name: peptidyl-tyrosine dehydrogenation to form (Z)-2,3-didehydrotyrosine
namespace: biological_process
def: "The oxidation of the C alpha-C beta bond of peptidyl-tyrosine to form peptidyl-(Z)-2,3-didehydrotyrosine coupled with cyclization of neighboring residues." [PMID:9631087, RESID:AA0183]
subset: gosubset_prok
xref: RESID:AA0183
is_a: GO:0018251 ! peptidyl-tyrosine dehydrogenation

[Term]
id: GO:0030922
name: peptidyl-tyrosine dehydrogenation to form (E)-2,3-didehydrotyrosine
namespace: biological_process
def: "The oxidation of the C alpha-C beta bond of peptidyl-tyrosine to form peptidyl-(E)-2,3-didehydrotyrosine coupled with cyclization of neighboring residues." [PMID:12623015, RESID:AA0365]
subset: gosubset_prok
xref: RESID:AA0365
is_a: GO:0018251 ! peptidyl-tyrosine dehydrogenation

[Term]
id: GO:0030923
name: metal incorporation into metallo-oxygen cluster
namespace: biological_process
def: "The formation of a cluster of several metal atoms, including manganese or calcium, with one or more bridging (mu-bond) oxygen atoms; amino acids residues in proteins that may ligate the metal oxygen cluster are histidine, aspartate, and glutamate." [GOC:jsg]
subset: gosubset_prok
is_a: GO:0006464 ! cellular protein modification process

[Term]
id: GO:0030924
name: manganese incorporation into metallo-oxygen cluster
namespace: biological_process
def: "The incorporation of manganese into a metallo-oxygen cluster." [GOC:jsg]
subset: gosubset_prok
is_a: GO:0030923 ! metal incorporation into metallo-oxygen cluster

[Term]
id: GO:0030925
name: calcium incorporation into metallo-oxygen cluster
namespace: biological_process
def: "The incorporation of calcium into a metallo-oxygen cluster." [GOC:jsg]
subset: gosubset_prok
is_a: GO:0030923 ! metal incorporation into metallo-oxygen cluster

[Term]
id: GO:0030926
name: calcium incorporation into metallo-oxygen cluster via bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide
namespace: biological_process
def: "The incorporation of calcium into a 4Mn-Ca-4O complex by bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide as in the photosystem II catalytic site." [PMID:14764885, RESID:AA0366]
subset: gosubset_prok
xref: RESID:AA0366
is_a: GO:0030925 ! calcium incorporation into metallo-oxygen cluster

[Term]
id: GO:0030927
name: manganese incorporation into metallo-oxygen cluster via bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide
namespace: biological_process
def: "The incorporation of manganese into a 4Mn-Ca-4O complex by bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide as in the photosystem II catalytic site." [PMID:14764885, RESID:AA0366]
subset: gosubset_prok
xref: RESID:AA0366
is_a: GO:0030924 ! manganese incorporation into metallo-oxygen cluster

[Term]
id: GO:0030929
name: ADPG pyrophosphorylase complex
namespace: cellular_component
def: "Complex that possesses ADPG pyrophosphorylase activity. In all organisms where it has been found, the complex is a tetramer. In bacteria, it is a homotetramer. In plants, the complex is a heterotetramer composed small and large subunits." [GOC:tb, PMID:9680965]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0030930
name: homotetrameric ADPG pyrophosphorylase complex
namespace: cellular_component
def: "A protein complex composed of four identical subunits that possesses ADPG pyrophosphorylase activity. Examples of this component are found in Bacterial species." [GOC:mah, GOC:mtg_sensu]
subset: gosubset_prok
is_a: GO:0030929 ! ADPG pyrophosphorylase complex

[Term]
id: GO:0030931
name: heterotetrameric ADPG pyrophosphorylase complex
namespace: cellular_component
def: "A protein complex composed of four different subunits that possesses ADPG pyrophosphorylase activity. An example of this process is found in Mus musculus." [GOC:mah, GOC:mtg_sensu]
is_a: GO:0030929 ! ADPG pyrophosphorylase complex

[Term]
id: GO:0030932
name: amyloplast ADPG pyrophosphorylase complex
namespace: cellular_component
def: "An ADPG pyrophosphorylase complex found in the amyloplast." [GOC:mah]
is_a: GO:0031009 ! plastid ADPG pyrophosphorylase complex
intersection_of: GO:0030929 ! ADPG pyrophosphorylase complex
intersection_of: part_of GO:0009501 ! amyloplast
relationship: part_of GO:0009501 ! amyloplast

[Term]
id: GO:0030933
name: chloroplast ADPG pyrophosphorylase complex
namespace: cellular_component
def: "An ADPG pyrophosphorylase complex found in the chloroplast." [GOC:mah]
is_a: GO:0031009 ! plastid ADPG pyrophosphorylase complex
is_a: GO:0044434 ! chloroplast part
intersection_of: GO:0030929 ! ADPG pyrophosphorylase complex
intersection_of: part_of GO:0009507 ! chloroplast
relationship: part_of GO:0009507 ! chloroplast

[Term]
id: GO:0030934
name: anchoring collagen complex
namespace: cellular_component
def: "Any collagen complex which links one collagen assembly, such as a collagen fibril or sheet, to other structures." [ISBN:0721639976]
synonym: "connecting collagen" EXACT [ISBN:0721639976]
synonym: "linking collagen" EXACT [ISBN:0721639976]
is_a: GO:0005581 ! collagen trimer
is_a: GO:0044420 ! extracellular matrix component
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005578 ! proteinaceous extracellular matrix

[Term]
id: GO:0030935
name: sheet-forming collagen trimer
namespace: cellular_component
def: "sheet-forming collagen trimer" [ISBN:0721639976]
synonym: "hexagonal network-forming collagen" EXACT [ISBN:0815316194]
is_a: GO:0098642 ! network-forming collagen trimer
intersection_of: GO:0005581 ! collagen trimer
intersection_of: part_of GO:0098646 ! collagen sheet
relationship: part_of GO:0005578 ! proteinaceous extracellular matrix
relationship: part_of GO:0098646 ! collagen sheet

[Term]
id: GO:0030936
name: transmembrane collagen trimer
namespace: cellular_component
def: "Any collagen trimer that passes through a lipid bilayer membrane." [ISBN:0721639976]
synonym: "MACIT" EXACT [ISBN:0198599587]
is_a: GO:0005581 ! collagen trimer
is_a: GO:0098797 ! plasma membrane protein complex
intersection_of: GO:0005581 ! collagen trimer
intersection_of: part_of GO:0005887 ! integral component of plasma membrane
relationship: part_of GO:0005887 ! integral component of plasma membrane

[Term]
id: GO:0030937
name: collagen type XVII trimer
namespace: cellular_component
def: "A collagen homotrimer of alpha1(XVII) chains; type XVII collagen triple helices span the plasma membrane and associate with hemidesmosomes and the basal lamina where they bind laminin." [ISBN:0721639976, PMID:19693541, PMID:21421911]
is_a: GO:0030936 ! transmembrane collagen trimer
is_a: GO:0098637 ! protein complex involved in cell-matrix adhesion
is_a: GO:0098733 ! hemidesmosome associated protein complex
relationship: part_of GO:0005887 ! integral component of plasma membrane

[Term]
id: GO:0030938
name: collagen type XVIII trimer
namespace: cellular_component
def: "A collagen homotrimer of alpha1(XVIII) chains." [ISBN:0721639976, PMID:21421911]
is_a: GO:0098651 ! basement membrane collagen trimer
relationship: part_of GO:0005604 ! basement membrane

[Term]
id: GO:0030939
name: obsolete response to long-day photoperiod
namespace: biological_process
def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a photoperiod, an intermittent cycle of light (day) and dark (night) photoperiod regimes, with the light phase being longer than the dark." [GOC:pj]
comment: This term was made obsolete because it was wrongly defined.
synonym: "response to long-day photoperiod" EXACT []
is_obsolete: true
consider: GO:0048571

[Term]
id: GO:0030940
name: obsolete response to short-day photoperiod
namespace: biological_process
def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a photoperiod, an intermittent cycle of light (day) and dark (night) photoperiod regimes, with the dark phase being longer than the light." [GOC:pj]
comment: This term was made obsolete because it was wrongly defined.
synonym: "response to short-day photoperiod" EXACT []
is_obsolete: true
consider: GO:0048572

[Term]
id: GO:0030941
name: chloroplast targeting sequence binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a chloroplast targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the chloroplast." [GOC:mah]
is_a: GO:0005048 ! signal sequence binding

[Term]
id: GO:0030942
name: endoplasmic reticulum signal peptide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an endoplasmic reticulum signal peptide, a specific peptide sequence that acts as a signal to localize the protein within the endoplasmic reticulum." [GOC:mah]
synonym: "ER signal peptide binding" EXACT []
is_a: GO:0005048 ! signal sequence binding

[Term]
id: GO:0030943
name: mitochondrion targeting sequence binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a mitochondrion targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the mitochondrion." [GOC:mah]
synonym: "mitochondrial targeting sequence binding" EXACT []
is_a: GO:0005048 ! signal sequence binding

[Term]
id: GO:0030944
name: DDEL sequence binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a KDEL sequence, the C terminus tetrapeptide sequence Asp-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum." [GOC:mah]
is_a: GO:0046923 ! ER retention sequence binding

[Term]
id: GO:0030945
name: protein tyrosine phosphatase activity, via thiol-phosphate intermediate
namespace: molecular_function
def: "The catalysis of phosphate removal from a phosphotyrosine using cysteine as a nucleophile and proceed by means of a thiol-phosphate intermediate." [GOC:hjd]
is_a: GO:0004725 ! protein tyrosine phosphatase activity

[Term]
id: GO:0030946
name: protein tyrosine phosphatase activity, metal-dependent
namespace: molecular_function
def: "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. This reaction requires metal ions." [GOC:mah]
is_a: GO:0004725 ! protein tyrosine phosphatase activity

[Term]
id: GO:0030947
name: regulation of vascular endothelial growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity." [GOC:dgh]
synonym: "regulation of vascular endothelial growth factor receptor signalling pathway" EXACT []
synonym: "regulation of VEGF receptor signaling pathway" EXACT []
synonym: "regulation of VEGF receptor signalling pathway" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0090287 ! regulation of cellular response to growth factor stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048010 ! vascular endothelial growth factor receptor signaling pathway
relationship: regulates GO:0048010 ! vascular endothelial growth factor receptor signaling pathway

[Term]
id: GO:0030948
name: negative regulation of vascular endothelial growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity." [GOC:dgh]
synonym: "down regulation of vascular endothelial growth factor receptor signaling pathway" EXACT []
synonym: "down-regulation of vascular endothelial growth factor receptor signaling pathway" EXACT []
synonym: "downregulation of vascular endothelial growth factor receptor signaling pathway" EXACT []
synonym: "inhibition of vascular endothelial growth factor receptor signaling pathway" NARROW []
synonym: "negative regulation of vascular endothelial growth factor receptor signalling pathway" EXACT []
synonym: "negative regulation of VEGF receptor signaling pathway" EXACT []
synonym: "negative regulation of VEGF receptor signalling pathway" EXACT []
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0030947 ! regulation of vascular endothelial growth factor receptor signaling pathway
is_a: GO:0090288 ! negative regulation of cellular response to growth factor stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048010 ! vascular endothelial growth factor receptor signaling pathway
relationship: negatively_regulates GO:0048010 ! vascular endothelial growth factor receptor signaling pathway

[Term]
id: GO:0030949
name: positive regulation of vascular endothelial growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity." [GOC:dgh]
synonym: "activation of vascular endothelial growth factor receptor signaling pathway" NARROW []
synonym: "positive regulation of vascular endothelial growth factor receptor signalling pathway" EXACT []
synonym: "positive regulation of VEGF receptor signaling pathway" EXACT []
synonym: "positive regulation of VEGF receptor signalling pathway" EXACT []
synonym: "stimulation of vascular endothelial growth factor receptor signaling pathway" NARROW []
synonym: "up regulation of vascular endothelial growth factor receptor signaling pathway" EXACT []
synonym: "up-regulation of vascular endothelial growth factor receptor signaling pathway" EXACT []
synonym: "upregulation of vascular endothelial growth factor receptor signaling pathway" EXACT []
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0030947 ! regulation of vascular endothelial growth factor receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048010 ! vascular endothelial growth factor receptor signaling pathway
relationship: positively_regulates GO:0048010 ! vascular endothelial growth factor receptor signaling pathway

[Term]
id: GO:0030950
name: establishment or maintenance of actin cytoskeleton polarity
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of polarized actin-based cytoskeletal structures." [GOC:mah]
is_a: GO:0030036 ! actin cytoskeleton organization
is_a: GO:0030952 ! establishment or maintenance of cytoskeleton polarity

[Term]
id: GO:0030951
name: establishment or maintenance of microtubule cytoskeleton polarity
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of polarized microtubule-based cytoskeletal structures." [GOC:mah]
is_a: GO:0000226 ! microtubule cytoskeleton organization
is_a: GO:0030952 ! establishment or maintenance of cytoskeleton polarity

[Term]
id: GO:0030952
name: establishment or maintenance of cytoskeleton polarity
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures." [GOC:mah]
synonym: "cytoskeleton polarization" RELATED []
is_a: GO:0007010 ! cytoskeleton organization
is_a: GO:0007163 ! establishment or maintenance of cell polarity
is_a: GO:1902589 ! single-organism organelle organization

[Term]
id: GO:0030953
name: astral microtubule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of astral microtubules, any of the spindle microtubules that radiate in all directions from the spindle poles." [GOC:mah]
synonym: "astral microtubule organisation" EXACT [GOC:curators]
synonym: "astral microtubule organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0007051 ! spindle organization
is_a: GO:0031122 ! cytoplasmic microtubule organization

[Term]
id: GO:0030954
name: astral microtubule nucleation
namespace: biological_process
def: "The 'de novo' formation of an astral microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule." [GOC:mah]
is_a: GO:0007020 ! microtubule nucleation
is_a: GO:0030953 ! astral microtubule organization

[Term]
id: GO:0030955
name: potassium ion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with potassium (K+) ions." [GOC:mah]
subset: gosubset_prok
is_a: GO:0031420 ! alkali metal ion binding

[Term]
id: GO:0030956
name: glutamyl-tRNA(Gln) amidotransferase complex
namespace: cellular_component
def: "A protein complex that possesses glutamyl-tRNA(Gln) amidotransferase activity, and therefore creates Gln-tRNA by amidating Glu-tRNA; usually composed of 3 subunits: A, B, and C. Note that the C subunit may not be required in all organisms." [GOC:mlg]
comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity ; GO:0050567'.
synonym: "AdT" RELATED [GOC:rb]
synonym: "GatCAB" NARROW [GOC:rb]
synonym: "GatFAB" NARROW [GOC:rb]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0030957
name: Tat protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with Tat, a viral transactivating regulatory protein from the human immunodeficiency virus, or the equivalent protein from another virus." [GOC:mah, PMID:9094689]
is_a: GO:0008134 ! transcription factor binding

[Term]
id: GO:0030958
name: RITS complex
namespace: cellular_component
def: "A protein complex required for heterochromatin assembly; contains an Argonaute homolog, a chromodomain protein, and at least one additional protein; named for RNA-induced initiation of transcriptional gene silencing." [PMID:14704433]
is_a: GO:0031332 ! RNAi effector complex
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0005720 ! nuclear heterochromatin

[Term]
id: GO:0030959
name: peptide cross-linking via 3'-(3'-L-tyrosinyl)-L-tyrosine
namespace: biological_process
def: "The modification of two peptidyl-tyrosines to form a 3'-(3'-L-tyrosinyl)-L-tyrosine protein cross-link." [RESID:AA0367]
subset: gosubset_prok
xref: RESID:AA0367
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018212 ! peptidyl-tyrosine modification

[Term]
id: GO:0030960
name: peptide cross-linking via 3'-(O4'-L-tyrosinyl)-L-tyrosine
namespace: biological_process
def: "The modification of two peptidyl-tyrosines to form a 3'-(O4'-L-tyrosinyl)-L-tyrosine protein cross-link." [PDB:1NGK, PMID:12719529, RESID:AA0368]
subset: gosubset_prok
xref: RESID:AA0368
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018212 ! peptidyl-tyrosine modification

[Term]
id: GO:0030961
name: peptidyl-arginine hydroxylation
namespace: biological_process
def: "The hydroxylation of peptidyl-arginine to form peptidyl-hydroxyarginine." [GOC:mah]
subset: gosubset_prok
is_a: GO:0018195 ! peptidyl-arginine modification

[Term]
id: GO:0030962
name: peptidyl-arginine dihydroxylation to peptidyl-3,4-dihydroxy-L-arginine
namespace: biological_process
def: "The dihydroxylation of peptidyl-arginine to form peptidyl-3,4-dihydroxy-L-arginine." [PMID:10978343, RESID:AA0369]
subset: gosubset_prok
xref: RESID:AA0369
is_a: GO:0030961 ! peptidyl-arginine hydroxylation

[Term]
id: GO:0030963
name: peptidyl-lysine dihydroxylation to 4,5-dihydroxy-L-lysine
namespace: biological_process
def: "The dihydroxylation of peptidyl-lysine to peptidyl-4,5-dihydroxy-L-lysine." [PMID:10978343, RESID:AA0370]
subset: gosubset_prok
xref: RESID:AA0370
is_a: GO:0017185 ! peptidyl-lysine hydroxylation

[Term]
id: GO:0030964
name: NADH dehydrogenase complex
namespace: cellular_component
alt_id: GO:0030025
alt_id: GO:0030966
alt_id: GO:0031675
alt_id: GO:0031677
alt_id: GO:0031678
alt_id: GO:0045280
def: "An integral membrane complex that possesses NADH oxidoreductase activity. The complex is one of the components of the electron transport chain. It catalyzes the transfer of a pair of electrons from NADH to a quinone." [GOC:mah]
comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'NADH dehydrogenase (quinone) activity ; GO:0050136'.
subset: goslim_pir
subset: gosubset_prok
synonym: "Complex I" EXACT []
synonym: "NADH dehydrogenase complex (plastoquinone)" NARROW []
synonym: "NADH dehydrogenase complex (quinone)" NARROW []
synonym: "NADH dehydrogenase complex (ubiquinone)" NARROW []
synonym: "NADH:plastoquinone reductase complex" NARROW []
synonym: "plastid NADH dehydrogenase complex (plastoquinone)" NARROW []
xref: Wikipedia:NADH_dehydrogenase
is_a: GO:0098796 ! membrane protein complex
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:0030965
name: plasma membrane electron transport, NADH to quinone
namespace: biological_process
def: "The transfer of electrons from NADH to the quinone pool that occurs during oxidative phosphorylation and results in the generation of a proton gradient, mediated by the enzyme known as NADH-quinone oxidoreductase." [GOC:mah, GOC:sd]
subset: gosubset_prok
is_a: GO:0022904 ! respiratory electron transport chain
relationship: part_of GO:0042774 ! plasma membrane ATP synthesis coupled electron transport

[Term]
id: GO:0030968
name: endoplasmic reticulum unfolded protein response
namespace: biological_process
def: "The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation." [GOC:mah, PMID:12042763]
comment: Note that this term should not be confused with 'response to unfolded protein ; GO:0006986', which refers to any response to the presence of unfolded proteins anywhere in the cell or in multicellular organism. Also see 'ER-associated protein catabolic process ; GO:0030433'.
synonym: "ER unfolded protein response" EXACT []
synonym: "erUPR" EXACT []
synonym: "SREBP-mediated signalling pathway" RELATED []
xref: Reactome:REACT_102268 "Unfolded Protein Response, Saccharomyces cerevisiae"
xref: Reactome:REACT_104319 "Unfolded Protein Response, Dictyostelium discoideum"
xref: Reactome:REACT_18356 "Unfolded Protein Response, Homo sapiens"
xref: Reactome:REACT_29195 "Unfolded Protein Response, Danio rerio"
xref: Reactome:REACT_32369 "Unfolded Protein Response, Rattus norvegicus"
xref: Reactome:REACT_33997 "Unfolded Protein Response, Mus musculus"
xref: Reactome:REACT_34742 "Unfolded Protein Response, Bos taurus"
xref: Reactome:REACT_76959 "Unfolded Protein Response, Arabidopsis thaliana"
xref: Reactome:REACT_79574 "Unfolded Protein Response, Oryza sativa"
xref: Reactome:REACT_84351 "Unfolded Protein Response, Gallus gallus"
xref: Reactome:REACT_84686 "Unfolded Protein Response, Canis familiaris"
xref: Reactome:REACT_86876 "Unfolded Protein Response, Schizosaccharomyces pombe"
xref: Reactome:REACT_88034 "Unfolded Protein Response, Sus scrofa"
xref: Reactome:REACT_89826 "Unfolded Protein Response, Drosophila melanogaster"
xref: Reactome:REACT_92132 "Unfolded Protein Response, Caenorhabditis elegans"
xref: Reactome:REACT_93381 "Unfolded Protein Response, Xenopus tropicalis"
xref: Reactome:REACT_94656 "Unfolded Protein Response, Taeniopygia guttata"
is_a: GO:0007165 ! signal transduction
is_a: GO:0034976 ! response to endoplasmic reticulum stress
relationship: part_of GO:0034620 ! cellular response to unfolded protein

[Term]
id: GO:0030969
name: mRNA splicing via endonucleolytic cleavage and ligation involved in unfolded protein response
namespace: biological_process
def: "The spliceosome-independent cleavage and ligation of the mRNA encoding a UFP-specific transcription factor to remove a single intron, thereby increasing both the translational efficiency of the processed mRNA and the activity of the protein it encodes." [GOC:mah, PMID:12042763, PMID:21924241]
comment: This term includes the recognition, cleavage and ligation steps in unconventional mRNA splicing. When annotating the endoribonuclease, consider instead the more specific term 'mRNA endonucleolytic cleavage involved in unfolded protein response ; GO:0070055'.
synonym: "HAC1 mRNA splicing" NARROW [PMID:21924241]
synonym: "IRE1-mediated XBP-1 mRNA splicing" NARROW [GOC:bf]
synonym: "Ire1p-mediated HAC-1 mRNA splicing" NARROW [GOC:bf]
synonym: "non-spliceosomal mRNA splicing in the unfolded protein response pathway" EXACT [PMID:10357823]
synonym: "spliceosome-independent UFP-specific transcription factor mRNA processing" EXACT [GOC:dph]
synonym: "UFP-specific transcription factor mRNA processing during unfolded protein response" RELATED [GOC:dph, GOC:tb]
synonym: "UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response" EXACT [GOC:bf]
synonym: "UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum UPR" EXACT [GOC:bf]
synonym: "UFP-specific transcription factor mRNA processing involved in ER unfolded protein response" EXACT [GOC:bf]
synonym: "UFP-specific transcription factor mRNA processing involved in ER UPR" EXACT [GOC:bf]
synonym: "unconventional mRNA splicing involved in UPR" EXACT [GOC:bf]
synonym: "unconventional splicing of XBP1 mRNA" EXACT [PMID:11779464, PMID:26068456]
synonym: "unfolded protein response, cleavage of primary transcript encoding UFP-specific transcription factor" RELATED []
synonym: "unfolded protein response, ligation of mRNA encoding UFP-specific transcription factor by RNA ligase" RELATED []
synonym: "XBP1 mRNA splicing" EXACT [PMID:11779464, PMID:25968568]
synonym: "XBP1 mRNA splicing under conditions of endoplasmic reticulum (ER) stress" NARROW [PMID:21924241]
synonym: "XBP1 mRNA splicing, via endonucleolytic cleavage and ligation" EXACT [GOC:bf]
is_a: GO:0070054 ! mRNA splicing, via endonucleolytic cleavage and ligation
relationship: part_of GO:0036498 ! IRE1-mediated unfolded protein response

[Term]
id: GO:0030970
name: retrograde protein transport, ER to cytosol
namespace: biological_process
def: "The directed movement of unfolded or misfolded proteins from the endoplasmic reticulum to the cytosol through the translocon." [PMID:11994744]
synonym: "protein dislocation from ER" EXACT [GOC:dph, GOC:krc]
synonym: "protein retrotranslocation, ER to cytosol" EXACT [GOC:bf]
synonym: "retrograde protein transport, endoplasmic reticulum to cytosol" EXACT []
is_a: GO:0032527 ! protein exit from endoplasmic reticulum
is_a: GO:1903513 ! endoplasmic reticulum to cytosol transport
relationship: part_of GO:0036503 ! ERAD pathway

[Term]
id: GO:0030971
name: receptor tyrosine kinase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a receptor that possesses protein tyrosine kinase activity." [GOC:mah]
synonym: "transmembrane receptor protein tyrosine kinase ligand binding" RELATED []
is_a: GO:0005102 ! receptor binding
is_a: GO:1990782 ! protein tyrosine kinase binding

[Term]
id: GO:0030972
name: obsolete cleavage of cytosolic proteins involved in execution phase of apoptosis
namespace: biological_process
def: "OBSOLETE. The proteolytic degradation of proteins in the cytosol that contributes to apoptosis." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, ISBN:0815332181]
comment: This term was obsoleted because it refers to targets of effector proteins (caspases); the 'cleavage' process referred to in the term name is in fact the same molecular function represented by GO:0097200 'cysteine-type endopeptidase activity involved in execution phase of apoptosis'.
synonym: "apoptotic cleavage of cytosolic proteins" EXACT []
synonym: "cleavage of cytosolic proteins involved in apoptosis" BROAD []
synonym: "cleavage of cytosolic proteins involved in execution phase of apoptosis" EXACT []
is_obsolete: true
consider: GO:0097200

[Term]
id: GO:0030973
name: molybdate ion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with molybdate (MoO4 2-) ions." [GOC:mlg]
subset: gosubset_prok
is_a: GO:0043168 ! anion binding

[Term]
id: GO:0030974
name: thiamine pyrophosphate transport
namespace: biological_process
def: "The directed movement of thiamine pyrophosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mlg]
synonym: "thiamin diphosphate transport" EXACT []
synonym: "thiamin pyrophosphate transport" EXACT [GOC:curators]
synonym: "thiamine diphosphate transport" EXACT []
synonym: "TPP transport" EXACT []
is_a: GO:0015695 ! organic cation transport
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015748 ! organophosphate ester transport
is_a: GO:0045117 ! azole transport
is_a: GO:0051181 ! cofactor transport
is_a: GO:0072348 ! sulfur compound transport

[Term]
id: GO:0030975
name: thiamine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:mlg]
synonym: "thiamin binding" EXACT [GOC:curators]
synonym: "vitamin B1 binding" EXACT []
is_a: GO:0019842 ! vitamin binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding
is_a: GO:1901681 ! sulfur compound binding

[Term]
id: GO:0030976
name: thiamine pyrophosphate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases." [CHEBI:45931, GOC:mlg]
synonym: "aneurine pyrophosphate binding" EXACT []
synonym: "cocarboxylase binding" EXACT []
synonym: "diphosphothiamin binding" EXACT []
synonym: "thiamin pyrophosphate binding" EXACT [GOC:curators]
synonym: "TPP binding" EXACT []
is_a: GO:0019842 ! vitamin binding
is_a: GO:0043168 ! anion binding
is_a: GO:0043169 ! cation binding
is_a: GO:0050662 ! coenzyme binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding
is_a: GO:1901681 ! sulfur compound binding

[Term]
id: GO:0030977
name: taurine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with taurine." [GOC:mlg]
is_a: GO:1901681 ! sulfur compound binding

[Term]
id: GO:0030978
name: alpha-glucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving alpha-glucans, compounds composed of glucose residues linked by alpha-D-glucosidic bonds." [GOC:mah]
subset: gosubset_prok
synonym: "alpha-glucan metabolism" EXACT []
is_a: GO:0006073 ! cellular glucan metabolic process

[Term]
id: GO:0030979
name: alpha-glucan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of alpha-glucans, compounds composed of glucose residues linked by alpha-D-glucosidic bonds." [GOC:mah]
synonym: "alpha-glucan anabolism" EXACT []
synonym: "alpha-glucan biosynthesis" EXACT []
synonym: "alpha-glucan formation" EXACT []
synonym: "alpha-glucan synthesis" EXACT []
is_a: GO:0009250 ! glucan biosynthetic process
is_a: GO:0030978 ! alpha-glucan metabolic process

[Term]
id: GO:0030980
name: alpha-glucan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of alpha-glucans." [GOC:mah]
subset: gosubset_prok
synonym: "alpha-glucan breakdown" EXACT []
synonym: "alpha-glucan catabolism" EXACT []
synonym: "alpha-glucan degradation" EXACT []
is_a: GO:0009251 ! glucan catabolic process
is_a: GO:0030978 ! alpha-glucan metabolic process
is_a: GO:0044247 ! cellular polysaccharide catabolic process

[Term]
id: GO:0030981
name: cortical microtubule cytoskeleton
namespace: cellular_component
def: "The portion of the microtubule cytoskeleton that lies just beneath the plasma membrane." [GOC:mah]
is_a: GO:0030863 ! cortical cytoskeleton
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0015630 ! microtubule cytoskeleton

[Term]
id: GO:0030982
name: adventurous gliding motility
namespace: biological_process
def: "A process involved in the controlled movement of a bacterial cell powered by the rearward secretion of carbohydrate slime." [GOC:mlg, PMID:11967173]
subset: gosubset_prok
synonym: "adventurous gliding movement" EXACT []
is_a: GO:0071976 ! cell gliding

[Term]
id: GO:0030983
name: mismatched DNA binding
namespace: molecular_function
alt_id: GO:0032134
def: "Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches." [GOC:mah]
synonym: "mispair binding" EXACT []
synonym: "mispaired DNA binding" EXACT []
is_a: GO:0003690 ! double-stranded DNA binding

[Term]
id: GO:0030984
name: kininogen binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a kininogen, any of a group of plasma proteins that are kinin precursors." [GOC:mah, PMID:9520414]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0030985
name: high molecular weight kininogen binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a kininogen of high molecular mass." [GOC:mah, PMID:9520414]
synonym: "HK binding" EXACT []
synonym: "HMW kininogen binding" EXACT []
is_a: GO:0030984 ! kininogen binding

[Term]
id: GO:0030986
name: low molecular weight kininogen binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a kininogen of low molecular mass." [GOC:mah, PMID:9520414]
synonym: "LK binding" EXACT []
synonym: "LMW kininogen binding" EXACT []
is_a: GO:0030984 ! kininogen binding

[Term]
id: GO:0030987
name: high molecular weight kininogen receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a high molecular weight kininogen receptor." [GOC:mah]
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0030988
name: high molecular weight kininogen receptor complex
namespace: cellular_component
def: "A protein complex that acts as a receptor for high molecular weight kininogens. In humans, this receptor includes the CK1 and uPAR proteins." [GOC:mah, PMID:11290596]
is_a: GO:0098802 ! plasma membrane receptor complex
relationship: part_of GO:0005887 ! integral component of plasma membrane

[Term]
id: GO:0030989
name: dynein-driven meiotic oscillatory nuclear movement
namespace: biological_process
def: "Oscillatory movement of the nucleus involved in meiosis I. This oscillatory movement is led by an astral microtubule array emanating from the spindle pole body, and driven by the microtubule motor cytoplasmic dynein." [GOC:vw, PMID:16111942, PMID:9572142]
comment: Dynein-driven meiotic oscillatory nuclear movement precedes meiotic recombination.
synonym: "HNM" EXACT []
synonym: "horsetail movement" EXACT []
synonym: "horsetail nuclear movement" EXACT [GOC:vw]
is_a: GO:0030473 ! nuclear migration along microtubule
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0007127 ! meiosis I

[Term]
id: GO:0030990
name: intraciliary transport particle
namespace: cellular_component
def: "A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules." [GOC:cilia, GOC:kmv, PMID:14570576, PMID:22118932, PMID:23945166]
comment: Note that we deem cilia and microtubule-based flagella to be equivalent.
subset: goslim_pir
synonym: "IFT complex" RELATED []
synonym: "intraflagellar transport complex" EXACT []
synonym: "intraflagellar transport particle" EXACT []
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0030991
name: intraciliary transport particle A
namespace: cellular_component
def: "The smaller subcomplex of the intraciliary transport particle; characterized complexes have molecular weights of 710-760 kDa." [GOC:cilia, GOC:kmv, PMID:14570576]
comment: Note that we deem cilia and microtubule-based flagella to be equivalent.
synonym: "IFT A complex" RELATED []
synonym: "intraflagellar transport complex A" EXACT []
synonym: "intraflagellar transport particle A" EXACT []
is_a: GO:0043234 ! protein complex
relationship: part_of GO:0030990 ! intraciliary transport particle

[Term]
id: GO:0030992
name: intraciliary transport particle B
namespace: cellular_component
def: "The larger subcomplex of the intraciliary transport particle; characterized complexes have molecular weights around 550 kDa." [GOC:cilia, GOC:kmv, PMID:14570576, PMID:19253336]
comment: Note that we deem cilia and microtubule-based flagella to be equivalent.
synonym: "IFT B complex" RELATED []
synonym: "IFT complex B" EXACT []
synonym: "intraflagellar transport complex B" EXACT []
synonym: "intraflagellar transport particle B" EXACT []
is_a: GO:0043234 ! protein complex
relationship: part_of GO:0030990 ! intraciliary transport particle

[Term]
id: GO:0030993
name: axonemal heterotrimeric kinesin-II complex
namespace: cellular_component
def: "A kinesin complex found in eukaryotic axonemes that contains two distinct plus end-directed kinesin motor proteins and at least one accessory subunit, and that functions in the anterograde transport of molecules (cargo) from the basal body to the distal tip of the axoneme." [GOC:kmv, PMID:14570576]
is_a: GO:0043234 ! protein complex
is_a: GO:0044447 ! axoneme part

[Term]
id: GO:0030994
name: primary cell septum disassembly
namespace: biological_process
def: "Dissolution of the primary septum during cell separation." [PMID:12665550]
synonym: "hydrolysis of primary cell septum" EXACT []
synonym: "primary cell septum hydrolysis" EXACT []
synonym: "primary septum hydrolysis" BROAD []
is_a: GO:0022411 ! cellular component disassembly
relationship: part_of GO:0000920 ! cell separation after cytokinesis

[Term]
id: GO:0030995
name: cell septum edging catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the dissolution of the septum edging during cell separation." [GOC:mah, PMID:15194814]
synonym: "cell septum edging hydrolysis" EXACT []
synonym: "hydrolysis of cell septum edging" EXACT []
synonym: "hydrolysis of edging of cell septum" EXACT []
synonym: "septum edging hydrolysis" BROAD []
is_a: GO:0044724 ! single-organism carbohydrate catabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0071999 ! extracellular polysaccharide catabolic process
relationship: part_of GO:0000920 ! cell separation after cytokinesis

[Term]
id: GO:0030996
name: obsolete mitotic cell cycle arrest in response to nitrogen starvation
namespace: biological_process
def: "OBSOLETE. The process in which the mitotic cell cycle is halted during one of the normal phases (G1, S, G2, M) as a result of deprivation of nitrogen." [GOC:dph, GOC:mah, GOC:tb, GOC:vw]
comment: This term was made obsolete because it is superfluous, as only the more specific 'mitotic G1 cell cycle arrest in response to nitrogen starvation' has been observed.
synonym: "cell cycle arrest in response to nitrogen starvation" BROAD []
is_obsolete: true

[Term]
id: GO:0030997
name: regulation of centriole-centriole cohesion
namespace: biological_process
def: "Any process that modulates the extent to which the two centrioles within a centrosome remain tightly paired; may be mediated by the assembly and disassembly of a proteinaceous linker." [PMID:11076968]
is_a: GO:0070507 ! regulation of microtubule cytoskeleton organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010457 ! centriole-centriole cohesion
relationship: part_of GO:0007098 ! centrosome cycle
relationship: regulates GO:0010457 ! centriole-centriole cohesion

[Term]
id: GO:0030998
name: linear element
namespace: cellular_component
def: "A proteinaceous scaffold associated with S. pombe chromosomes during meiotic prophase. Linear elements have a structure related to but not equivalent to the synaptonemal complex." [GOC:jb]
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000794 ! condensed nuclear chromosome

[Term]
id: GO:0030999
name: linear element assembly
namespace: biological_process
def: "The cell cycle process in which a proteinaceous scaffold, related to the synaptonemal complex, is assembled in association with S. pombe chromosomes during meiotic prophase." [GOC:jb, GOC:mah]
synonym: "linear element formation" RELATED [GOC:dph]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0007129 ! synapsis

[Term]
id: GO:0031000
name: response to caffeine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them." [CHEBI:27732, GOC:ef, GOC:mah]
is_a: GO:0014074 ! response to purine-containing compound
is_a: GO:0043279 ! response to alkaloid

[Term]
id: GO:0031001
name: response to brefeldin A
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brefeldin A stimulus." [GOC:mah]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0046677 ! response to antibiotic
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0031002
name: actin rod
namespace: cellular_component
def: "A cellular structure consisting of parallel, hexagonally arranged actin tubules, comprising filamentous actin and associated proteins. Found in the germinating spores of Dictyostelium discoideum." [GOC:kp]
is_a: GO:0032432 ! actin filament bundle
relationship: part_of GO:0015629 ! actin cytoskeleton

[Term]
id: GO:0031003
name: actin tubule
namespace: cellular_component
def: "A cellular structure, approximately 13 nm in diameter, consisting of three actin filaments bundled together." [GOC:kp]
is_a: GO:0032432 ! actin filament bundle
relationship: part_of GO:0031002 ! actin rod

[Term]
id: GO:0031004
name: potassium ion-transporting ATPase complex
namespace: cellular_component
def: "Protein complex that carries out the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in). It is a high affinity potassium uptake system. The E. coli complex consists of 4 proteins: KdpA is the potassium ion translocase, KdpB is the ATPase, and KdpC and KdpF seem to be involved in assembly and stabilization of the complex." [PMID:10608856, PMID:9858692, TIGR_TIGRFAMS:TIGR01497]
synonym: "Kdp system complex" EXACT []
is_a: GO:0090533 ! cation-transporting ATPase complex

[Term]
id: GO:0031005
name: filamin binding
namespace: molecular_function
alt_id: GO:0031006
alt_id: GO:0031007
alt_id: GO:0031008
def: "Interacting selectively and non-covalently with a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain." [GOC:mah, PMID:11336782]
synonym: "ABP-278/276 binding" NARROW []
synonym: "ABP-280 binding" NARROW []
synonym: "ABPL binding" NARROW []
synonym: "alpha-filamin binding" NARROW []
synonym: "beta-filamin binding" NARROW []
synonym: "filamin A binding" NARROW []
synonym: "filamin B binding" NARROW []
synonym: "filamin C binding" EXACT []
synonym: "filamin-1 binding" NARROW []
synonym: "filamin-2 binding" NARROW []
synonym: "filamin-3 binding" NARROW []
synonym: "filamin-A binding" NARROW []
synonym: "filamin-B binding" EXACT []
synonym: "filamin-C binding" NARROW []
synonym: "gamma-filamin binding" NARROW []
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0031009
name: plastid ADPG pyrophosphorylase complex
namespace: cellular_component
def: "An ADPG pyrophosphorylase complex found in a plastid." [GOC:mah]
is_a: GO:0030931 ! heterotetrameric ADPG pyrophosphorylase complex
is_a: GO:0044435 ! plastid part
intersection_of: GO:0030929 ! ADPG pyrophosphorylase complex
intersection_of: part_of GO:0009536 ! plastid
relationship: part_of GO:0009536 ! plastid

[Term]
id: GO:0031010
name: ISWI-type complex
namespace: cellular_component
def: "Any nuclear protein complex that contains an ATPase subunit of the imitation switch (ISWI) family. ISWI ATPases are involved in assembling chromatin and in sliding and spacing nucleosomes to regulate transcription of nuclear RNA polymerases I, II, and III and also DNA replication, recombination and repair." [GOC:krc, GOC:mah, PMID:15020051, PMID:15284901, PMID:16568949, PMID:21810179]
is_a: GO:0070603 ! SWI/SNF superfamily-type complex

[Term]
id: GO:0031011
name: Ino80 complex
namespace: cellular_component
def: "A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity and 3' to 5' DNA helicase activity." [GOC:jh, GOC:rb, PMID:19355820]
synonym: "INO80 chromatin remodeling complex" EXACT []
is_a: GO:0033202 ! DNA helicase complex
is_a: GO:0044454 ! nuclear chromosome part
is_a: GO:0097346 ! INO80-type complex
relationship: part_of GO:0000790 ! nuclear chromatin

[Term]
id: GO:0031012
name: extracellular matrix
namespace: cellular_component
def: "A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513]
subset: goslim_metagenomics
subset: goslim_pir
subset: gosubset_prok
xref: NIF_Subcellular:nlx_subcell_20090513
xref: Wikipedia:Extracellular_matrix
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0031013
name: troponin I binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with troponin I, the inhibitory subunit of the troponin complex." [GOC:mah, ISBN:0815316194]
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0031014
name: troponin T binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with troponin T, the tropomyosin-binding subunit of the troponin complex." [GOC:mah, ISBN:0815316194]
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0031015
name: obsolete karyopherin docking complex
namespace: cellular_component
def: "OBSOLETE. A subcomplex of the nuclear pore complex that interacts with karyopherin-cargo complexes; a well-characterized example in Saccharomyces contains Asm4p, Nup53p, and Nup170p." [PMID:11867631, PMID:9864357]
synonym: "Asm4p-containing complex" NARROW []
synonym: "karyopherin docking complex" EXACT []
synonym: "nuclear pore subcomplex" BROAD []
is_obsolete: true
consider: GO:0005487
consider: GO:0044613

[Term]
id: GO:0031016
name: pancreas development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes." [GOC:cvs]
xref: Wikipedia:Pancreas
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048513 ! animal organ development

[Term]
id: GO:0031017
name: exocrine pancreas development
namespace: biological_process
def: "The process whose specific outcome is the progression of the exocrine pancreas over time, from its formation to the mature structure. The exocrine pancreas produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells." [GOC:cvs]
is_a: GO:0048732 ! gland development
relationship: part_of GO:0031016 ! pancreas development
relationship: part_of GO:0035272 ! exocrine system development
relationship: part_of GO:0055123 ! digestive system development

[Term]
id: GO:0031018
name: endocrine pancreas development
namespace: biological_process
def: "The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin." [GOC:cvs]
xref: Reactome:REACT_100172 "Regulation of beta-cell development, Staphylococcus aureus N315"
xref: Reactome:REACT_100239 "Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells, Canis familiaris"
xref: Reactome:REACT_101492 "Regulation of gene expression in beta cells, Canis familiaris"
xref: Reactome:REACT_102188 "Regulation of beta-cell development, Escherichia coli"
xref: Reactome:REACT_102956 "Regulation of beta-cell development, Sus scrofa"
xref: Reactome:REACT_105131 "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells, Sus scrofa"
xref: Reactome:REACT_105242 "Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells, Taeniopygia guttata"
xref: Reactome:REACT_105455 "Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells, Mus musculus"
xref: Reactome:REACT_105798 "Regulation of gene expression in early pancreatic precursor cells, Drosophila melanogaster"
xref: Reactome:REACT_106781 "Regulation of beta-cell development, Gallus gallus"
xref: Reactome:REACT_107233 "Regulation of beta-cell development, Caenorhabditis elegans"
xref: Reactome:REACT_107418 "Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells, Rattus norvegicus"
xref: Reactome:REACT_108013 "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells, Xenopus tropicalis"
xref: Reactome:REACT_108544 "Regulation of gene expression in early pancreatic precursor cells, Xenopus tropicalis"
xref: Reactome:REACT_111030 "Regulation of gene expression in beta cells, Danio rerio"
xref: Reactome:REACT_112937 "Regulation of gene expression in beta cells, Mycobacterium tuberculosis"
xref: Reactome:REACT_114067 "Regulation of beta-cell development, Mycobacterium tuberculosis"
xref: Reactome:REACT_13641 "Regulation of Beta-Cell Development, Mus musculus"
xref: Reactome:REACT_13650 "Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells, Homo sapiens"
xref: Reactome:REACT_13673 "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells, Homo sapiens"
xref: Reactome:REACT_13698 "Regulation of beta-cell development, Homo sapiens"
xref: Reactome:REACT_13778 "Regulation of gene expression in early pancreatic precursor cells, Homo sapiens"
xref: Reactome:REACT_13819 "Regulation of gene expression in beta cells, Homo sapiens"
xref: Reactome:REACT_28720 "Regulation of gene expression in beta cells, Caenorhabditis elegans"
xref: Reactome:REACT_29082 "Regulation of gene expression in beta cells, Gallus gallus"
xref: Reactome:REACT_29825 "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells, Canis familiaris"
xref: Reactome:REACT_30048 "Regulation of gene expression in early pancreatic precursor cells, Canis familiaris"
xref: Reactome:REACT_31811 "Regulation of gene expression in early pancreatic precursor cells, Bos taurus"
xref: Reactome:REACT_33149 "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells, Drosophila melanogaster"
xref: Reactome:REACT_33362 "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells, Caenorhabditis elegans"
xref: Reactome:REACT_33643 "Regulation of beta-cell development, Bos taurus"
xref: Reactome:REACT_33882 "Regulation of gene expression in beta cells, Arabidopsis thaliana"
xref: Reactome:REACT_33965 "Regulation of gene expression in beta cells, Rattus norvegicus"
xref: Reactome:REACT_34484 "Regulation of beta-cell development, Schizosaccharomyces pombe"
xref: Reactome:REACT_77445 "Regulation of beta-cell development, Oryza sativa"
xref: Reactome:REACT_77538 "Regulation of gene expression in beta cells, Bos taurus"
xref: Reactome:REACT_78194 "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells, Rattus norvegicus"
xref: Reactome:REACT_78480 "Regulation of gene expression in beta cells, Saccharomyces cerevisiae"
xref: Reactome:REACT_79238 "Regulation of beta-cell development, Danio rerio"
xref: Reactome:REACT_79240 "Regulation of gene expression in early pancreatic precursor cells, Gallus gallus"
xref: Reactome:REACT_79285 "Regulation of gene expression in beta cells, Dictyostelium discoideum"
xref: Reactome:REACT_80121 "Regulation of beta-cell development, Plasmodium falciparum"
xref: Reactome:REACT_80317 "Regulation of gene expression in early pancreatic precursor cells, Mus musculus"
xref: Reactome:REACT_82017 "Regulation of beta-cell development, Xenopus tropicalis"
xref: Reactome:REACT_82782 "Regulation of gene expression in beta cells, Xenopus tropicalis"
xref: Reactome:REACT_82897 "Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells, Danio rerio"
xref: Reactome:REACT_83026 "Regulation of gene expression in beta cells, Oryza sativa"
xref: Reactome:REACT_83105 "Regulation of gene expression in beta cells, Escherichia coli"
xref: Reactome:REACT_83129 "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells, Bos taurus"
xref: Reactome:REACT_83414 "Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells, Sus scrofa"
xref: Reactome:REACT_85060 "Regulation of gene expression in early pancreatic precursor cells, Taeniopygia guttata"
xref: Reactome:REACT_85721 "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells, Gallus gallus"
xref: Reactome:REACT_86199 "Regulation of gene expression in beta cells, Mus musculus"
xref: Reactome:REACT_86989 "Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells, Xenopus tropicalis"
xref: Reactome:REACT_87974 "Regulation of beta-cell development, Rattus norvegicus"
xref: Reactome:REACT_88048 "Regulation of gene expression in beta cells, Taeniopygia guttata"
xref: Reactome:REACT_89334 "Regulation of gene expression in beta cells, Schizosaccharomyces pombe"
xref: Reactome:REACT_89352 "Regulation of beta-cell development, Arabidopsis thaliana"
xref: Reactome:REACT_89883 "Regulation of beta-cell development, Mus musculus"
xref: Reactome:REACT_89999 "Regulation of beta-cell development, Taeniopygia guttata"
xref: Reactome:REACT_90418 "Regulation of beta-cell development, Saccharomyces cerevisiae"
xref: Reactome:REACT_90603 "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells, Danio rerio"
xref: Reactome:REACT_91799 "Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells, Bos taurus"
xref: Reactome:REACT_92191 "Regulation of gene expression in early pancreatic precursor cells, Caenorhabditis elegans"
xref: Reactome:REACT_92743 "Regulation of gene expression in beta cells, Staphylococcus aureus N315"
xref: Reactome:REACT_93408 "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells, Mus musculus"
xref: Reactome:REACT_93479 "Regulation of beta-cell development, Drosophila melanogaster"
xref: Reactome:REACT_93693 "Regulation of beta-cell development, Dictyostelium discoideum"
xref: Reactome:REACT_94334 "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells, Taeniopygia guttata"
xref: Reactome:REACT_94430 "Regulation of gene expression in early pancreatic precursor cells, Danio rerio"
xref: Reactome:REACT_95482 "Regulation of gene expression in early pancreatic precursor cells, Sus scrofa"
xref: Reactome:REACT_95696 "Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells, Gallus gallus"
xref: Reactome:REACT_97083 "Regulation of gene expression in beta cells, Drosophila melanogaster"
xref: Reactome:REACT_97526 "Regulation of gene expression in early pancreatic precursor cells, Rattus norvegicus"
xref: Reactome:REACT_97545 "Regulation of gene expression in beta cells, Plasmodium falciparum"
xref: Reactome:REACT_98354 "Regulation of beta-cell development, Canis familiaris"
xref: Reactome:REACT_99516 "Regulation of gene expression in beta cells, Sus scrofa"
xref: Reactome:REACT_99600 "Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells, Caenorhabditis elegans"
xref: Reactome:REACT_99890 "Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells, Drosophila melanogaster"
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0031016 ! pancreas development
relationship: part_of GO:0035270 ! endocrine system development

[Term]
id: GO:0031019
name: mitochondrial mRNA editing complex
namespace: cellular_component
def: "An mRNA editing complex found in the mitochondrion. The best characterized example is that of Trypanosoma brucei, which catalyzes the insertion and deletion of uridylates." [GOC:mah, PMID:12139607]
synonym: "mitochondrial editosome" EXACT []
is_a: GO:0045293 ! mRNA editing complex
is_a: GO:0098798 ! mitochondrial protein complex
intersection_of: GO:0045293 ! mRNA editing complex
intersection_of: part_of GO:0005739 ! mitochondrion
relationship: part_of GO:0005739 ! mitochondrion

[Term]
id: GO:0031020
name: plastid mRNA editing complex
namespace: cellular_component
def: "An mRNA editing complex found in a plastid." [GOC:mah]
synonym: "plastid editosome" EXACT []
is_a: GO:0044435 ! plastid part
is_a: GO:0045293 ! mRNA editing complex
intersection_of: GO:0045293 ! mRNA editing complex
intersection_of: part_of GO:0009536 ! plastid
relationship: part_of GO:0009536 ! plastid

[Term]
id: GO:0031021
name: interphase microtubule organizing center
namespace: cellular_component
def: "A microtubule organizing center found in interphase cells, which organize a longitudinal array of three to five MT bundles from the nuclear envelope during interphase. Each MT bundle is composed of two to seven MTs arranged in an antiparallel configuration, with the dynamic MT plus ends extending toward the cell tips and stable minus ends near the nucleus." [PMID:15068790]
synonym: "iMTOC" EXACT []
synonym: "interphase microtubule organising center" EXACT []
synonym: "interphase MTOC" EXACT []
is_a: GO:0005815 ! microtubule organizing center

[Term]
id: GO:0031022
name: nuclear migration along microfilament
namespace: biological_process
def: "The directed movement of the nucleus along microfilaments within the cell, mediated by motor proteins." [GOC:mah]
synonym: "nuclear migration, microfilament-mediated" EXACT []
is_a: GO:0007097 ! nuclear migration
is_a: GO:0030048 ! actin filament-based movement
is_a: GO:0099515 ! actin filament-based transport
is_a: GO:1902580 ! single-organism cellular localization

[Term]
id: GO:0031023
name: microtubule organizing center organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow." [GOC:dph, GOC:jl, GOC:mah]
subset: goslim_pir
synonym: "microtubule organising center organisation" EXACT [GOC:curators]
synonym: "microtubule organizing center organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization
relationship: part_of GO:0000226 ! microtubule cytoskeleton organization

[Term]
id: GO:0031024
name: interphase microtubule organizing center assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components, including gamma-tubulin and other proteins, to form an interphase microtubule organizing center." [GOC:mah, PMID:15068790]
synonym: "interphase microtubule organising center biosynthesis" EXACT []
synonym: "interphase microtubule organising center formation" EXACT []
synonym: "interphase microtubule organizing center biogenesis" RELATED [GOC:mah]
synonym: "interphase microtubule organizing centre assembly" EXACT []
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0031023 ! microtubule organizing center organization

[Term]
id: GO:0031025
name: equatorial microtubule organizing center disassembly
namespace: biological_process
def: "The process in which the equatorial microtubule organizing center is disassembled at the end of mitosis." [GOC:mah, PMID:15068790]
synonym: "equatorial microtubule organising center disassembly" EXACT []
is_a: GO:0022411 ! cellular component disassembly
is_a: GO:0031023 ! microtubule organizing center organization
is_a: GO:0031121 ! equatorial microtubule organization

[Term]
id: GO:0031026
name: glutamate synthase complex
namespace: cellular_component
def: "A complex that possesses glutamate synthase activity." [GOC:mah]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0044424 ! intracellular part
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:0031027
name: glutamate synthase complex (NADH)
namespace: cellular_component
def: "A protein complex that in yeast consists of a large and a small subunit. Possesses glutamate synthase (NADH) activity." [GOC:jl, PMID:7047525]
is_a: GO:0031026 ! glutamate synthase complex

[Term]
id: GO:0031028
name: septation initiation signaling
namespace: biological_process
def: "The series of molecular signals, mediated by the small GTPase Ras, that results in the initiation of contraction of the contractile ring, at the beginning of cytokinesis and cell division by septum formation. The pathway coordinates chromosome segregation with mitotic exit and cytokinesis." [GOC:mah, GOC:vw, PMID:16775007]
synonym: "septation initiation network" EXACT []
synonym: "septation initiation signaling cascade" RELATED [GOC:signaling]
synonym: "septation initiation signalling" EXACT []
synonym: "SIN" EXACT []
is_a: GO:0007096 ! regulation of exit from mitosis
is_a: GO:0007265 ! Ras protein signal transduction
is_a: GO:0031991 ! regulation of actomyosin contractile ring contraction
is_a: GO:1901893 ! positive regulation of cell septum assembly
is_a: GO:1903438 ! positive regulation of mitotic cytokinetic process

[Term]
id: GO:0031029
name: regulation of septation initiation signaling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of septation initiation signaling." [GOC:mah]
synonym: "regulation of septation initiation network" EXACT []
synonym: "regulation of septation initiation signaling cascade" RELATED [GOC:signaling]
synonym: "regulation of septation initiation signalling" EXACT []
is_a: GO:0007096 ! regulation of exit from mitosis
is_a: GO:0031991 ! regulation of actomyosin contractile ring contraction
is_a: GO:0046578 ! regulation of Ras protein signal transduction
is_a: GO:1901891 ! regulation of cell septum assembly
is_a: GO:1903436 ! regulation of mitotic cytokinetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031028 ! septation initiation signaling
relationship: regulates GO:0031028 ! septation initiation signaling

[Term]
id: GO:0031030
name: negative regulation of septation initiation signaling
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of septation initiation signaling." [GOC:mah]
synonym: "down regulation of septation initiation signaling" EXACT []
synonym: "down-regulation of septation initiation signaling" EXACT []
synonym: "downregulation of septation initiation signaling" EXACT []
synonym: "inhibition of septation initiation signaling" NARROW []
synonym: "negative regulation of septation initiation network" EXACT []
synonym: "negative regulation of septation initiation signaling cascade" RELATED [GOC:signaling]
synonym: "negative regulation of septation initiation signalling" EXACT []
is_a: GO:0010974 ! negative regulation of barrier septum assembly
is_a: GO:0031029 ! regulation of septation initiation signaling
is_a: GO:0046580 ! negative regulation of Ras protein signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0031028 ! septation initiation signaling
relationship: negatively_regulates GO:0031028 ! septation initiation signaling

[Term]
id: GO:0031031
name: positive regulation of septation initiation signaling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of septation initiation signaling." [GOC:mah]
synonym: "activation of septation initiation signaling" NARROW []
synonym: "positive regulation of septation initiation network" EXACT []
synonym: "positive regulation of septation initiation signaling cascade" RELATED [GOC:signaling]
synonym: "positive regulation of septation initiation signalling" EXACT []
synonym: "stimulation of septation initiation signaling" NARROW []
synonym: "up regulation of septation initiation signaling" EXACT []
synonym: "up-regulation of septation initiation signaling" EXACT []
synonym: "upregulation of septation initiation signaling" EXACT []
is_a: GO:0010973 ! positive regulation of barrier septum assembly
is_a: GO:0031029 ! regulation of septation initiation signaling
is_a: GO:0046579 ! positive regulation of Ras protein signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0031028 ! septation initiation signaling
relationship: positively_regulates GO:0031028 ! septation initiation signaling

[Term]
id: GO:0031032
name: actomyosin structure organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments." [GOC:dph, GOC:jl, GOC:mah]
comment: Note that this term is a child of 'actin cytoskeleton organization and biogenesis ; GO:0030036' because the actin cytoskeleton is defined as actin filaments and associated proteins.
synonym: "actomyosin organization" EXACT []
synonym: "actomyosin structure organisation" EXACT [GOC:curators]
synonym: "actomyosin structure organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0030036 ! actin cytoskeleton organization

[Term]
id: GO:0031033
name: myosin filament organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a filament composed of myosin molecules." [GOC:mah]
comment: Note that this term is a child of 'actin cytoskeleton organization and biogenesis ; GO:0030036' because the actin cytoskeleton is defined as actin filaments and associated proteins; myosin structures are sufficiently closely associated with actin filaments to be included with the actin cytoskeleton.
synonym: "myosin filament assembly or disassembly" RELATED [GOC:mah]
synonym: "myosin filament organisation" EXACT [GOC:mah]
synonym: "myosin polymerization or depolymerization" RELATED []
is_a: GO:0030036 ! actin cytoskeleton organization
is_a: GO:0071822 ! protein complex subunit organization

[Term]
id: GO:0031034
name: myosin filament assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a filament composed of myosin molecules." [GOC:mah]
synonym: "myosin polymerization" RELATED []
is_a: GO:0031033 ! myosin filament organization
is_a: GO:0043623 ! cellular protein complex assembly

[Term]
id: GO:0031035
name: myosin filament disassembly
namespace: biological_process
def: "The disassembly of a filament composed of myosin molecules." [GOC:mah]
synonym: "myosin depolymerization" RELATED []
is_a: GO:0031033 ! myosin filament organization
is_a: GO:0043624 ! cellular protein complex disassembly

[Term]
id: GO:0031036
name: myosin II filament assembly
namespace: biological_process
def: "The formation of a bipolar filament composed of myosin II molecules." [GOC:mah]
synonym: "myosin II polymerization" RELATED []
is_a: GO:0031034 ! myosin filament assembly
is_a: GO:0031038 ! myosin II filament organization

[Term]
id: GO:0031037
name: myosin II filament disassembly
namespace: biological_process
def: "The disassembly of a bipolar filament composed of myosin II molecules." [GOC:mah]
synonym: "myosin II depolymerization" RELATED []
is_a: GO:0031035 ! myosin filament disassembly
is_a: GO:0031038 ! myosin II filament organization

[Term]
id: GO:0031038
name: myosin II filament organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a bipolar filament composed of myosin II molecules." [GOC:mah]
synonym: "myosin II filament assembly or disassembly" RELATED [GOC:mah]
synonym: "myosin II filament organisation" EXACT [GOC:mah]
synonym: "myosin II polymerization or depolymerization" RELATED []
is_a: GO:0031033 ! myosin filament organization

[Term]
id: GO:0031039
name: macronucleus
namespace: cellular_component
def: "A membrane-bounded organelle of ciliated protozoan cells that contains polyploid copies of a portion of the cell's complete genome. Transcription of genes occurs in macronuclei. Some ciliate species may contain multiple macronuclei per cell." [GOC:ns]
xref: Wikipedia:Macronucleus
is_a: GO:0005634 ! nucleus

[Term]
id: GO:0031040
name: micronucleus
namespace: cellular_component
def: "A membrane-bounded organelle of ciliated protozoan cells that contains a diploid copy of the cell's complete genome. Sections of contiguous sequence in the macronucleus are often interrupted by internal eliminated sequences (IES), and may be permuted, in micronuclei. Genic transcription is not found in micronuclei. Some ciliate species may contain multiple micronuclei per cell." [GOC:ns]
xref: Wikipedia:Micronucleus
is_a: GO:0005634 ! nucleus

[Term]
id: GO:0031041
name: O-glycan processing, core 5
namespace: biological_process
def: "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 5 O-glycan structure, GalNAc-alpha-(1->3)-GalNAc." [GOC:mah, GOC:pr, PMID:10580130]
subset: gosubset_prok
is_a: GO:0016266 ! O-glycan processing

[Term]
id: GO:0031042
name: O-glycan processing, core 6
namespace: biological_process
def: "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 6 O-glycan structure, GlcNAc-beta-(1->6)-GalNAc." [GOC:mah, GOC:pr, PMID:10580130]
subset: gosubset_prok
is_a: GO:0016266 ! O-glycan processing

[Term]
id: GO:0031043
name: O-glycan processing, core 7
namespace: biological_process
def: "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 7 O-glycan structure, GalNAc-alpha-(1->6)-GalNAc." [GOC:mah, GOC:pr, PMID:10580130]
subset: gosubset_prok
is_a: GO:0016266 ! O-glycan processing

[Term]
id: GO:0031044
name: O-glycan processing, core 8
namespace: biological_process
def: "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 8 O-glycan structure, Gal-alpha-(1->3)-GalNAc." [GOC:mah, GOC:pr, PMID:10580130]
subset: gosubset_prok
is_a: GO:0016266 ! O-glycan processing

[Term]
id: GO:0031045
name: dense core granule
namespace: cellular_component
def: "Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted." [NIF_Subcellular:sao772007592, PMID:14690495]
synonym: "dense core vesicle" EXACT [GOC:kmv]
xref: NIF_Subcellular:sao772007592
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0031047
name: gene silencing by RNA
namespace: biological_process
def: "Any process in which RNA molecules inactivate expression of target genes." [GOC:dph, GOC:mah, GOC:tb, PMID:15020054]
synonym: "RNA-mediated gene silencing" EXACT [GOC:dph, GOC:tb]
is_a: GO:0016458 ! gene silencing

[Term]
id: GO:0031048
name: chromatin silencing by small RNA
namespace: biological_process
def: "Repression of transcription by conversion of large regions of DNA into heterochromatin, directed by small RNAs sharing sequence identity to the repressed region." [GOC:dph, GOC:mtg_lung, GOC:ns]
synonym: "RNA interference-like chromatin silencing" EXACT []
synonym: "RNA-mediated chromatin silencing" EXACT [GOC:dph, GOC:tb]
synonym: "RNA-mediated TGS" BROAD []
synonym: "RNA-mediated transcriptional silencing" EXACT []
synonym: "RNAi-directed chromatin silencing" EXACT [GOC:vw]
synonym: "RNAi-like chromatin silencing" EXACT []
synonym: "small RNA-mediated heterochromatic silencing" EXACT []
is_a: GO:0006342 ! chromatin silencing
is_a: GO:0031047 ! gene silencing by RNA

[Term]
id: GO:0031049
name: programmed DNA elimination
namespace: biological_process
def: "The DNA metabolic process in which micronuclear-limited sequences, internal eliminated sequences (IES) and breakage eliminated sequences (BES) are removed from the developing macronucleus (anlage) of a ciliate." [GOC:mah, GOC:ns]
subset: goslim_pir
is_a: GO:0006259 ! DNA metabolic process

[Term]
id: GO:0031050
name: dsRNA fragmentation
namespace: biological_process
def: "Cleavage of double-stranded RNA molecules by an RNaseIII-family enzyme to produce small RNAs (generally 20-30 nucleotides, depending on species) with biological function." [GOC:ns]
synonym: "double-stranded RNA fragmentation" EXACT []
is_a: GO:0006396 ! RNA processing
is_a: GO:0044710 ! single-organism metabolic process
is_a: GO:0044763 ! single-organism cellular process
relationship: part_of GO:0071359 ! cellular response to dsRNA

[Term]
id: GO:0031051
name: scnRNA production
namespace: biological_process
def: "Cleavage of noncoding, double-stranded RNAs transcribed from the micronuclear genome to produce scnRNAs, small RNAs (~28 nucleotides) that direct the deletion of micronuclear-limited sequences from the developing macronuclear genome." [PMID:15196465]
is_a: GO:0031050 ! dsRNA fragmentation
relationship: part_of GO:0031049 ! programmed DNA elimination

[Term]
id: GO:0031052
name: chromosome breakage
namespace: biological_process
def: "Regulated cleavage of the developing macronuclear genome at a limited number of chromosome breakage sites (CBS). The macronuclear destined segment (MDS) sequence adjacent to the CBS (or separated from it by a BES) receives a macronuclear telomere following chromosome breakage." [GOC:ns]
comment: Note that this term refers to breakage of chromosomes during normal DNA rearrangements characteristic of ciliates; it is not to be used for DNA damage or other abnormal occurrences.
synonym: "establishment or maintenance of heterochromatin architecture" EXACT [GOC:mah]
is_a: GO:0051276 ! chromosome organization
relationship: part_of GO:0031049 ! programmed DNA elimination

[Term]
id: GO:0031053
name: primary miRNA processing
namespace: biological_process
def: "Any process involved in the conversion of a primary microRNA transcript into a pre-microRNA molecule." [GOC:sl, PMID:15211354]
synonym: "pri-miRNA processing" EXACT []
synonym: "primary microRNA processing" EXACT []
is_a: GO:0034470 ! ncRNA processing
relationship: part_of GO:0035196 ! production of miRNAs involved in gene silencing by miRNA

[Term]
id: GO:0031054
name: pre-miRNA processing
namespace: biological_process
def: "Any process involved in the conversion of a pre-microRNA transcript into a mature microRNA molecule." [GOC:sl, PMID:15211354]
synonym: "pre-microRNA processing" EXACT []
is_a: GO:0034470 ! ncRNA processing
relationship: part_of GO:0035196 ! production of miRNAs involved in gene silencing by miRNA

[Term]
id: GO:0031055
name: chromatin remodeling at centromere
namespace: biological_process
def: "Dynamic structural changes in centromeric DNA." [GOC:mah]
is_a: GO:0006338 ! chromatin remodeling

[Term]
id: GO:0031056
name: regulation of histone modification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the covalent alteration of a histone." [GOC:mah]
is_a: GO:0031399 ! regulation of protein modification process
is_a: GO:1903308 ! regulation of chromatin modification
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016570 ! histone modification
relationship: regulates GO:0016570 ! histone modification

[Term]
id: GO:0031057
name: negative regulation of histone modification
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of a histone." [GOC:mah]
synonym: "down regulation of histone modification" EXACT []
synonym: "down-regulation of histone modification" EXACT []
synonym: "downregulation of histone modification" EXACT []
synonym: "inhibition of histone modification" NARROW []
is_a: GO:0031056 ! regulation of histone modification
is_a: GO:0031400 ! negative regulation of protein modification process
is_a: GO:1903309 ! negative regulation of chromatin modification
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016570 ! histone modification
relationship: negatively_regulates GO:0016570 ! histone modification

[Term]
id: GO:0031058
name: positive regulation of histone modification
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the covalent alteration of a histone." [GOC:mah]
synonym: "activation of histone modification" NARROW []
synonym: "stimulation of histone modification" NARROW []
synonym: "up regulation of histone modification" EXACT []
synonym: "up-regulation of histone modification" EXACT []
synonym: "upregulation of histone modification" EXACT []
is_a: GO:0031056 ! regulation of histone modification
is_a: GO:0031401 ! positive regulation of protein modification process
is_a: GO:1903310 ! positive regulation of chromatin modification
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016570 ! histone modification
relationship: positively_regulates GO:0016570 ! histone modification

[Term]
id: GO:0031059
name: histone deacetylation at centromere
namespace: biological_process
def: "The removal of acetyl groups from histones in centromeric DNA." [GOC:mah]
is_a: GO:0016575 ! histone deacetylation

[Term]
id: GO:0031060
name: regulation of histone methylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the covalent addition of methyl groups to histones." [GOC:mah]
is_a: GO:0031056 ! regulation of histone modification
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016571 ! histone methylation
relationship: regulates GO:0016571 ! histone methylation

[Term]
id: GO:0031061
name: negative regulation of histone methylation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of methyl groups to histones." [GOC:mah]
synonym: "down regulation of histone methylation" EXACT []
synonym: "down-regulation of histone methylation" EXACT []
synonym: "downregulation of histone methylation" EXACT []
synonym: "inhibition of histone methylation" NARROW []
is_a: GO:0031057 ! negative regulation of histone modification
is_a: GO:0031060 ! regulation of histone methylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016571 ! histone methylation
relationship: negatively_regulates GO:0016571 ! histone methylation

[Term]
id: GO:0031062
name: positive regulation of histone methylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the covalent addition of methyl groups to histones." [GOC:mah]
synonym: "activation of histone methylation" NARROW []
synonym: "stimulation of histone methylation" NARROW []
synonym: "up regulation of histone methylation" EXACT []
synonym: "up-regulation of histone methylation" EXACT []
synonym: "upregulation of histone methylation" EXACT []
is_a: GO:0031058 ! positive regulation of histone modification
is_a: GO:0031060 ! regulation of histone methylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016571 ! histone methylation
relationship: positively_regulates GO:0016571 ! histone methylation

[Term]
id: GO:0031063
name: regulation of histone deacetylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the removal of acetyl groups from histones." [GOC:mah]
is_a: GO:0031056 ! regulation of histone modification
is_a: GO:0090311 ! regulation of protein deacetylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016575 ! histone deacetylation
relationship: regulates GO:0016575 ! histone deacetylation

[Term]
id: GO:0031064
name: negative regulation of histone deacetylation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the removal of acetyl groups from histones." [GOC:mah]
synonym: "down regulation of histone deacetylation" EXACT []
synonym: "down-regulation of histone deacetylation" EXACT []
synonym: "downregulation of histone deacetylation" EXACT []
synonym: "inhibition of histone deacetylation" NARROW []
is_a: GO:0031057 ! negative regulation of histone modification
is_a: GO:0031063 ! regulation of histone deacetylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016575 ! histone deacetylation
relationship: negatively_regulates GO:0016575 ! histone deacetylation

[Term]
id: GO:0031065
name: positive regulation of histone deacetylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones." [GOC:mah]
synonym: "activation of histone deacetylation" NARROW []
synonym: "stimulation of histone deacetylation" NARROW []
synonym: "up regulation of histone deacetylation" EXACT []
synonym: "up-regulation of histone deacetylation" EXACT []
synonym: "upregulation of histone deacetylation" EXACT []
is_a: GO:0031058 ! positive regulation of histone modification
is_a: GO:0031063 ! regulation of histone deacetylation
is_a: GO:0090312 ! positive regulation of protein deacetylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016575 ! histone deacetylation
relationship: positively_regulates GO:0016575 ! histone deacetylation

[Term]
id: GO:0031066
name: regulation of histone deacetylation at centromere
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the removal of acetyl groups from histones in centromeric DNA." [GOC:mah]
is_a: GO:0031063 ! regulation of histone deacetylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031059 ! histone deacetylation at centromere
relationship: regulates GO:0031059 ! histone deacetylation at centromere

[Term]
id: GO:0031067
name: negative regulation of histone deacetylation at centromere
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the removal of acetyl groups to histones in centromeric DNA." [GOC:mah]
synonym: "down regulation of histone deacetylation at centromere" EXACT []
synonym: "down-regulation of histone deacetylation at centromere" EXACT []
synonym: "downregulation of histone deacetylation at centromere" EXACT []
synonym: "inhibition of histone deacetylation at centromere" NARROW []
is_a: GO:0031064 ! negative regulation of histone deacetylation
is_a: GO:0031066 ! regulation of histone deacetylation at centromere
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0031059 ! histone deacetylation at centromere
relationship: negatively_regulates GO:0031059 ! histone deacetylation at centromere

[Term]
id: GO:0031068
name: positive regulation of histone deacetylation at centromere
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones in centromeric DNA." [GOC:mah]
synonym: "activation of histone deacetylation at centromere" NARROW []
synonym: "stimulation of histone deacetylation at centromere" NARROW []
synonym: "up regulation of histone deacetylation at centromere" EXACT []
synonym: "up-regulation of histone deacetylation at centromere" EXACT []
synonym: "upregulation of histone deacetylation at centromere" EXACT []
is_a: GO:0031065 ! positive regulation of histone deacetylation
is_a: GO:0031066 ! regulation of histone deacetylation at centromere
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0031059 ! histone deacetylation at centromere
relationship: positively_regulates GO:0031059 ! histone deacetylation at centromere

[Term]
id: GO:0031069
name: hair follicle morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the hair follicle are generated and organized." [GOC:ln]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0022405 ! hair cycle process
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0001942 ! hair follicle development
relationship: part_of GO:0048730 ! epidermis morphogenesis

[Term]
id: GO:0031070
name: intronic snoRNA processing
namespace: biological_process
def: "The biogenesis of a snoRNA molecule which resides within, and is processed from, the intron of a pre-mRNA." [GOC:vw]
is_a: GO:0043144 ! snoRNA processing

[Term]
id: GO:0031071
name: cysteine desulfurase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine." [EC:2.8.1.7]
subset: gosubset_prok
synonym: "cysteine desulfurylase activity" EXACT [EC:2.8.1.7]
synonym: "IscS" RELATED [EC:2.8.1.7]
synonym: "L-cysteine:enzyme cysteine sulfurtransferase activity" EXACT [EC:2.8.1.7]
synonym: "NIFS" RELATED [EC:2.8.1.7]
synonym: "SufS" RELATED [EC:2.8.1.7]
xref: EC:2.8.1.7
xref: Reactome:REACT_24937 "NFS1 transfers sulfur from cysteine onto MOCS3, Homo sapiens"
is_a: GO:0016783 ! sulfurtransferase activity

[Term]
id: GO:0031072
name: heat shock protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a heat shock protein, any protein synthesized or activated in response to heat shock." [GOC:mah, GOC:vw]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0031073
name: cholesterol 26-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the hydroxylation of cholesterol at position 26 of the side chain, to produce 26-hydroxycholesterol." [GOC:mah, PMID:950499]
is_a: GO:0008395 ! steroid hydroxylase activity

[Term]
id: GO:0031074
name: nucleocytoplasmic shuttling complex
namespace: cellular_component
def: "Any complex that acts to move proteins or RNAs into or out of the nucleus through nuclear pores." [GOC:mah]
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0031076
name: embryonic camera-type eye development
namespace: biological_process
def: "The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure." [GOC:mah, GOC:mtg_sensu]
synonym: "embryonic eye development" EXACT []
is_a: GO:0043010 ! camera-type eye development
is_a: GO:0048568 ! embryonic organ development

[Term]
id: GO:0031077
name: post-embryonic camera-type eye development
namespace: biological_process
def: "The process occurring during the post-embryonic phase whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure." [GOC:mah, GOC:mtg_sensu]
synonym: "post-embryonic camera-style eye development" EXACT []
is_a: GO:0043010 ! camera-type eye development
is_a: GO:0048569 ! post-embryonic organ development
relationship: part_of GO:0009791 ! post-embryonic development

[Term]
id: GO:0031078
name: histone deacetylase activity (H3-K14 specific)
namespace: molecular_function
def: "Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein." [EC:3.5.1.17, RHEA:24551]
is_a: GO:0004407 ! histone deacetylase activity
relationship: part_of GO:0070932 ! histone H3 deacetylation

[Term]
id: GO:0031079
name: obsolete picornain 3C activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the selective cleavage of GlnGly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly." [EC:3.4.22.28]
comment: This term was made obsolete because it represents a gene product.
synonym: "3C protease activity" EXACT [EC:3.4.22.28]
synonym: "3C proteinase activity" EXACT [EC:3.4.22.28]
synonym: "coxsackievirus 3C proteinase activity" EXACT [EC:3.4.22.28]
synonym: "cysteine proteinase 3C" RELATED [EC:3.4.22.28]
synonym: "foot-and-mouth protease 3C activity" NARROW [EC:3.4.22.28]
synonym: "foot-and-mouth-disease virus proteinase 3C" RELATED [EC:3.4.22.28]
synonym: "hepatitis A virus 3C proteinase activity" EXACT [EC:3.4.22.28]
synonym: "picornain 3C activity" EXACT []
synonym: "picornavirus endopeptidase 3C activity" NARROW [EC:3.4.22.28]
synonym: "poliovirus protease 3C activity" NARROW [EC:3.4.22.28]
synonym: "poliovirus proteinase 3C" RELATED [EC:3.4.22.28]
synonym: "protease 3C" RELATED [EC:3.4.22.28]
synonym: "rhinovirus protease 3C activity" NARROW [EC:3.4.22.28]
synonym: "rhinovirus proteinase 3C" RELATED [EC:3.4.22.28]
synonym: "tomato ringspot nepovirus 3C-related protease" RELATED [EC:3.4.22.28]
xref: EC:3.4.22.28
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0031080
name: nuclear pore outer ring
namespace: cellular_component
def: "A subcomplex of the nuclear pore complex (NPC) that forms the outer rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two outer rings each contain multiple copies of the following proteins: Nup133p, Nup120p, Nup145Cp, Nup85p, Nup84p, Seh1p, and Sec13p. In vertebrates, the two outer rings each contain multiple copies of the following proteins: Nup133, Nup160, Nup96, Nup75, Nup107, Seh1, Sec13, Nup43, Nup37, and ALADIN. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup84 complex (S. cerevisiae) or the Nup107-160 complex (vertebrates)." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]
synonym: "Nup107-120 complex" EXACT []
synonym: "Nup107-160 complex" EXACT []
synonym: "Nup84 complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0005643 ! nuclear pore

[Term]
id: GO:0031081
name: nuclear pore distribution
namespace: biological_process
def: "Any process that establishes the spatial arrangement of nuclear pores within the nuclear envelope." [GOC:mah]
synonym: "positioning of nuclear pores" RELATED []
is_a: GO:0006997 ! nucleus organization
is_a: GO:0051664 ! nuclear pore localization
is_a: GO:1902580 ! single-organism cellular localization
is_a: GO:1902589 ! single-organism organelle organization

[Term]
id: GO:0031082
name: BLOC complex
namespace: cellular_component
def: "Any of several protein complexes required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes, platelet dense granules, and other related organelles; acronym for biogenesis of lysosomal-related organelles complex." [PMID:15102850, PMID:15261680]
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0031083
name: BLOC-1 complex
namespace: cellular_component
def: "A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins." [PMID:15102850]
is_a: GO:0031082 ! BLOC complex

[Term]
id: GO:0031084
name: BLOC-2 complex
namespace: cellular_component
def: "A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. The human complex contains the Hps3, Hps5, and Hps6 proteins; the mouse complex contains ru2 and ru." [PMID:12548288, PMID:14718540, PMID:15031569]
is_a: GO:0031082 ! BLOC complex

[Term]
id: GO:0031085
name: BLOC-3 complex
namespace: cellular_component
def: "A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. The human complex contains the Hps1 and Hps4 proteins." [PMID:12756248]
is_a: GO:0031082 ! BLOC complex

[Term]
id: GO:0031086
name: nuclear-transcribed mRNA catabolic process, deadenylation-independent decay
namespace: biological_process
def: "A pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of steps that is independent of deadenylation, but requires decapping followed by transcript decay, and that can regulate mRNA stability." [GOC:krc, PMID:15225542, PMID:15225544]
synonym: "deadenylation-independent mRNA decay" EXACT []
synonym: "deadenylylation-independent mRNA decay" EXACT []
synonym: "mRNA breakdown, deadenylation-independent decay" EXACT []
synonym: "mRNA catabolic process, deadenylation-independent" EXACT []
synonym: "mRNA catabolic process, deadenylylation-independent" EXACT []
synonym: "mRNA catabolism, deadenylation-independent" EXACT []
synonym: "mRNA catabolism, deadenylation-independent decay" EXACT []
synonym: "mRNA catabolism, deadenylylation-independent" EXACT []
synonym: "mRNA degradation, deadenylation-independent decay" EXACT []
synonym: "nuclear mRNA catabolic process, deadenylation-independent decay" EXACT []
is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process

[Term]
id: GO:0031087
name: deadenylation-independent decapping of nuclear-transcribed mRNA
namespace: biological_process
def: "Cleavage of the 5'-cap of a nuclear-transcribed mRNA that is independent of poly(A) tail shortening." [GOC:krc, PMID:15225542, PMID:15225544]
synonym: "deadenylation-independent decapping of nuclear mRNA" RELATED []
synonym: "deadenylylation-independent decapping" EXACT []
is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis
relationship: part_of GO:0031086 ! nuclear-transcribed mRNA catabolic process, deadenylation-independent decay

[Term]
id: GO:0031088
name: platelet dense granule membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the platelet dense granule." [GOC:mah]
is_a: GO:0030667 ! secretory granule membrane
relationship: part_of GO:0042827 ! platelet dense granule

[Term]
id: GO:0031089
name: platelet dense granule lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of the platelet dense granule." [GOC:mah]
is_a: GO:0034774 ! secretory granule lumen
relationship: part_of GO:0042827 ! platelet dense granule

[Term]
id: GO:0031090
name: organelle membrane
namespace: cellular_component
def: "A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle." [GOC:dos, GOC:mah]
subset: gosubset_prok
synonym: "intracellular membrane" RELATED [NIF_Subcellular:sao830981606]
xref: NIF_Subcellular:sao830981606
is_a: GO:0016020 ! membrane
is_a: GO:0044422 ! organelle part
relationship: part_of GO:0043227 ! membrane-bounded organelle

[Term]
id: GO:0031091
name: platelet alpha granule
namespace: cellular_component
def: "A secretory organelle found in blood platelets, which is unique in that it exhibits further compartmentalization and acquires its protein content via two distinct mechanisms: (1) biosynthesis predominantly at the megakaryocyte (MK) level (with some vestigial platelet synthesis) (e.g. platelet factor 4) and (2) endocytosis and pinocytosis at both the MK and circulating platelet levels (e.g. fibrinogen (Fg) and IgG)." [PMID:8467233]
synonym: "platelet alpha-granule" EXACT []
xref: Wikipedia:Platelet_alpha-granule
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0031092
name: platelet alpha granule membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the platelet alpha granule." [GOC:mah, PMID:8467233]
synonym: "platelet alpha-granule membrane" EXACT []
is_a: GO:0030667 ! secretory granule membrane
relationship: part_of GO:0031091 ! platelet alpha granule

[Term]
id: GO:0031093
name: platelet alpha granule lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of the platelet alpha granule." [GOC:mah, PMID:8467233]
synonym: "platelet alpha-granule lumen" EXACT []
is_a: GO:0034774 ! secretory granule lumen
relationship: part_of GO:0031091 ! platelet alpha granule

[Term]
id: GO:0031094
name: platelet dense tubular network
namespace: cellular_component
def: "A network of membrane-bounded compartments found in blood platelets, where they regulate platelet activation by sequestering or releasing calcium. The dense tubular network exists as thin elongated membranes in resting platelets, and undergoes a major ultrastructural change, to a rounded vesicular form, upon addition of thrombin." [PMID:1322202]
subset: goslim_pir
is_a: GO:0043231 ! intracellular membrane-bounded organelle

[Term]
id: GO:0031095
name: platelet dense tubular network membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the platelet dense tubular network." [GOC:mah, PMID:1322202]
is_a: GO:0044424 ! intracellular part
is_a: GO:0098588 ! bounding membrane of organelle
relationship: part_of GO:0031094 ! platelet dense tubular network

[Term]
id: GO:0031096
name: platelet dense tubular network lumen
namespace: cellular_component
def: "The volume enclosed by the membranes of the platelet dense tubular network." [GOC:mah, PMID:1322202]
is_a: GO:0070013 ! intracellular organelle lumen
relationship: part_of GO:0031094 ! platelet dense tubular network

[Term]
id: GO:0031097
name: medial cortex
namespace: cellular_component
def: "A medial cortical band overlaying the nucleus which acts as a landmark for contractile ring positioning and plays a role in cell cycle regulation." [GOC:vw, PMID:15572668, PMID:19474789]
synonym: "medial ring" EXACT [GOC:vw]
is_a: GO:0032155 ! cell division site part
is_a: GO:0099738 ! cell cortex region

[Term]
id: GO:0031098
name: stress-activated protein kinase signaling cascade
namespace: biological_process
def: "A series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays one or more of the signals." [GOC:mah]
synonym: "JNK signaling pathway" NARROW []
synonym: "JNK signalling pathway" NARROW []
synonym: "SAPK signaling pathway" EXACT []
synonym: "SAPK signalling pathway" EXACT []
synonym: "stress-activated protein kinase signaling pathway" EXACT []
synonym: "stress-activated protein kinase signalling pathway" EXACT []
is_a: GO:0033554 ! cellular response to stress
is_a: GO:0035556 ! intracellular signal transduction

[Term]
id: GO:0031099
name: regeneration
namespace: biological_process
def: "The regrowth of a lost or destroyed body part, such as an organ or tissue." [GOC:mah]
xref: Wikipedia:Regeneration_(biology)
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development

[Term]
id: GO:0031100
name: organ regeneration
namespace: biological_process
def: "The regrowth of a lost or destroyed organ." [GOC:mah]
is_a: GO:0031099 ! regeneration
is_a: GO:0048513 ! animal organ development

[Term]
id: GO:0031101
name: fin regeneration
namespace: biological_process
def: "The regrowth of fin tissue following its loss or destruction." [GOC:dgh]
is_a: GO:0042246 ! tissue regeneration

[Term]
id: GO:0031102
name: neuron projection regeneration
namespace: biological_process
def: "The regrowth of neuronal processes such as axons or dendrites in response to their loss or damage." [GOC:dgh, GOC:dph, GOC:tb]
synonym: "neurite regeneration" NARROW [GOC:mah]
is_a: GO:0031099 ! regeneration
is_a: GO:0031175 ! neuron projection development
is_a: GO:0033554 ! cellular response to stress

[Term]
id: GO:0031103
name: axon regeneration
namespace: biological_process
def: "The regrowth of axons following their loss or damage." [GOC:dgh, GOC:dph, GOC:tb]
is_a: GO:0031102 ! neuron projection regeneration
is_a: GO:0048678 ! response to axon injury
is_a: GO:0061564 ! axon development

[Term]
id: GO:0031104
name: dendrite regeneration
namespace: biological_process
def: "The regrowth of dendrites in response to their loss or damage." [GOC:dgh, GOC:dph, GOC:tb]
is_a: GO:0016358 ! dendrite development
is_a: GO:0031102 ! neuron projection regeneration

[Term]
id: GO:0031105
name: septin complex
namespace: cellular_component
def: "A protein complex containing septins.  Typically, these complexes contain multiple septins and are oligomeric." [GOC:mah, PMID:15385632]
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044448 ! cell cortex part
relationship: part_of GO:0032156 ! septin cytoskeleton

[Term]
id: GO:0031106
name: septin ring organization
namespace: biological_process
def: "Control of the formation, spatial distribution, and breakdown of the septin ring." [GOC:mah]
subset: gosubset_prok
synonym: "septin ring organisation" EXACT [GOC:curators]
is_a: GO:0032185 ! septin cytoskeleton organization

[Term]
id: GO:0031107
name: septin ring disassembly
namespace: biological_process
def: "The controlled breakdown of a septin ring." [GOC:mah]
is_a: GO:0031106 ! septin ring organization
is_a: GO:1903008 ! organelle disassembly

[Term]
id: GO:0031108
name: holo-[acyl-carrier-protein] biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of holo-[acyl-carrier protein]." [GOC:mlg]
synonym: "holo-[acyl-carrier protein] biosynthesis" EXACT []
synonym: "holo-[acyl-carrier-protein] anabolism" EXACT []
synonym: "holo-[acyl-carrier-protein] biosynthesis" EXACT []
synonym: "holo-[acyl-carrier-protein] formation" EXACT []
synonym: "holo-[acyl-carrier-protein] synthesis" EXACT []
is_a: GO:0042967 ! acyl-carrier-protein biosynthetic process

[Term]
id: GO:0031109
name: microtubule polymerization or depolymerization
namespace: biological_process
def: "Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule." [GOC:mah]
is_a: GO:0000226 ! microtubule cytoskeleton organization

[Term]
id: GO:0031110
name: regulation of microtubule polymerization or depolymerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule." [GOC:mah]
is_a: GO:0070507 ! regulation of microtubule cytoskeleton organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031109 ! microtubule polymerization or depolymerization
relationship: regulates GO:0031109 ! microtubule polymerization or depolymerization

[Term]
id: GO:0031111
name: negative regulation of microtubule polymerization or depolymerization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization or depolymerization." [GOC:mah]
synonym: "down regulation of microtubule polymerization or depolymerization" EXACT []
synonym: "down-regulation of microtubule polymerization or depolymerization" EXACT []
synonym: "downregulation of microtubule polymerization or depolymerization" EXACT []
synonym: "inhibition of microtubule polymerization or depolymerization" NARROW []
is_a: GO:0031110 ! regulation of microtubule polymerization or depolymerization
is_a: GO:0051494 ! negative regulation of cytoskeleton organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0031109 ! microtubule polymerization or depolymerization
relationship: negatively_regulates GO:0031109 ! microtubule polymerization or depolymerization

[Term]
id: GO:0031112
name: positive regulation of microtubule polymerization or depolymerization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of microtubule polymerization or depolymerization." [GOC:mah]
synonym: "activation of microtubule polymerization or depolymerization" NARROW []
synonym: "stimulation of microtubule polymerization or depolymerization" NARROW []
synonym: "up regulation of microtubule polymerization or depolymerization" EXACT []
synonym: "up-regulation of microtubule polymerization or depolymerization" EXACT []
synonym: "upregulation of microtubule polymerization or depolymerization" EXACT []
is_a: GO:0031110 ! regulation of microtubule polymerization or depolymerization
is_a: GO:0051495 ! positive regulation of cytoskeleton organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0031109 ! microtubule polymerization or depolymerization
relationship: positively_regulates GO:0031109 ! microtubule polymerization or depolymerization

[Term]
id: GO:0031113
name: regulation of microtubule polymerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of microtubule polymerization." [GOC:mah]
is_a: GO:0031110 ! regulation of microtubule polymerization or depolymerization
is_a: GO:0032271 ! regulation of protein polymerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0046785 ! microtubule polymerization
relationship: regulates GO:0046785 ! microtubule polymerization

[Term]
id: GO:0031114
name: regulation of microtubule depolymerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of microtubule depolymerization." [GOC:mah]
synonym: "regulation of microtubule disassembly" EXACT []
is_a: GO:0031110 ! regulation of microtubule polymerization or depolymerization
is_a: GO:1901879 ! regulation of protein depolymerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007019 ! microtubule depolymerization
relationship: regulates GO:0007019 ! microtubule depolymerization

[Term]
id: GO:0031115
name: negative regulation of microtubule polymerization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization." [GOC:mah]
synonym: "down regulation of microtubule polymerization" EXACT []
synonym: "down-regulation of microtubule polymerization" EXACT []
synonym: "downregulation of microtubule polymerization" EXACT []
synonym: "inhibition of microtubule polymerization" NARROW []
is_a: GO:0031111 ! negative regulation of microtubule polymerization or depolymerization
is_a: GO:0031113 ! regulation of microtubule polymerization
is_a: GO:0032272 ! negative regulation of protein polymerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0046785 ! microtubule polymerization
relationship: negatively_regulates GO:0046785 ! microtubule polymerization

[Term]
id: GO:0031116
name: positive regulation of microtubule polymerization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of microtubule polymerization." [GOC:mah]
synonym: "activation of microtubule polymerization" NARROW []
synonym: "stimulation of microtubule polymerization" NARROW []
synonym: "up regulation of microtubule polymerization" EXACT []
synonym: "up-regulation of microtubule polymerization" EXACT []
synonym: "upregulation of microtubule polymerization" EXACT []
is_a: GO:0031112 ! positive regulation of microtubule polymerization or depolymerization
is_a: GO:0031113 ! regulation of microtubule polymerization
is_a: GO:0032273 ! positive regulation of protein polymerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0046785 ! microtubule polymerization
relationship: positively_regulates GO:0046785 ! microtubule polymerization

[Term]
id: GO:0031117
name: positive regulation of microtubule depolymerization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of microtubule depolymerization." [GOC:mah]
synonym: "activation of microtubule depolymerization" NARROW []
synonym: "microtubule destabilization" EXACT []
synonym: "positive regulation of microtubule catastrophe" NARROW [GOC:dph, GOC:tb]
synonym: "positive regulation of microtubule disassembly" EXACT []
synonym: "stimulation of microtubule depolymerization" NARROW []
synonym: "up regulation of microtubule depolymerization" EXACT []
synonym: "up-regulation of microtubule depolymerization" EXACT []
synonym: "upregulation of microtubule depolymerization" EXACT []
is_a: GO:0031112 ! positive regulation of microtubule polymerization or depolymerization
is_a: GO:0031114 ! regulation of microtubule depolymerization
is_a: GO:1901881 ! positive regulation of protein depolymerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007019 ! microtubule depolymerization
relationship: positively_regulates GO:0007019 ! microtubule depolymerization

[Term]
id: GO:0031118
name: rRNA pseudouridine synthesis
namespace: biological_process
def: "The intramolecular conversion of uridine to pseudouridine in an rRNA molecule." [GOC:mah]
is_a: GO:0000154 ! rRNA modification
is_a: GO:0001522 ! pseudouridine synthesis

[Term]
id: GO:0031119
name: tRNA pseudouridine synthesis
namespace: biological_process
def: "The intramolecular conversion of uridine to pseudouridine in a tRNA molecule." [GOC:mah]
is_a: GO:0001522 ! pseudouridine synthesis
is_a: GO:0006400 ! tRNA modification

[Term]
id: GO:0031120
name: snRNA pseudouridine synthesis
namespace: biological_process
def: "The intramolecular conversion of uridine to pseudouridine in an snRNA molecule." [GOC:mah]
is_a: GO:0001522 ! pseudouridine synthesis
is_a: GO:0040031 ! snRNA modification

[Term]
id: GO:0031121
name: equatorial microtubule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins at the midpoint of a cell." [GOC:mah, GOC:vw]
synonym: "equatorial microtubule organisation" EXACT [GOC:curators]
synonym: "equatorial microtubule organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0000226 ! microtubule cytoskeleton organization

[Term]
id: GO:0031122
name: cytoplasmic microtubule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell." [GOC:mah]
synonym: "cytoplasmic microtubule organisation" EXACT [GOC:curators]
synonym: "cytoplasmic microtubule organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0000226 ! microtubule cytoskeleton organization
is_a: GO:0071822 ! protein complex subunit organization

[Term]
id: GO:0031123
name: RNA 3'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 3' end of an RNA molecule." [GOC:mah]
subset: gosubset_prok
synonym: "RNA 3' end processing" EXACT []
is_a: GO:0006396 ! RNA processing

[Term]
id: GO:0031124
name: mRNA 3'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 3' end of an mRNA molecule." [GOC:mah]
subset: gosubset_prok
synonym: "mRNA 3' end processing" EXACT []
xref: Reactome:REACT_102358 "mRNA 3'-end processing, Bos taurus"
xref: Reactome:REACT_105982 "mRNA 3'-end processing, Xenopus tropicalis"
xref: Reactome:REACT_112683 "mRNA 3'-end processing, Drosophila melanogaster"
xref: Reactome:REACT_113053 "mRNA 3'-end processing, Caenorhabditis elegans"
xref: Reactome:REACT_114937 "mRNA 3'-end processing, Arabidopsis thaliana"
xref: Reactome:REACT_115007 "mRNA 3'-end processing, Oryza sativa"
xref: Reactome:REACT_1849 "mRNA 3'-end processing, Homo sapiens"
xref: Reactome:REACT_29064 "mRNA 3'-end processing, Danio rerio"
xref: Reactome:REACT_76994 "mRNA 3'-end processing, Taeniopygia guttata"
xref: Reactome:REACT_85883 "mRNA 3'-end processing, Mus musculus"
xref: Reactome:REACT_99251 "mRNA 3'-end processing, Canis familiaris"
is_a: GO:0006397 ! mRNA processing
is_a: GO:0031123 ! RNA 3'-end processing

[Term]
id: GO:0031125
name: rRNA 3'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 3' end of an rRNA molecule." [GOC:mah]
synonym: "rRNA 3' end processing" EXACT []
is_a: GO:0006364 ! rRNA processing
is_a: GO:0043628 ! ncRNA 3'-end processing

[Term]
id: GO:0031126
name: snoRNA 3'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 3' end of a snoRNA molecule." [GOC:mah]
synonym: "snoRNA 3' end processing" EXACT []
is_a: GO:0043144 ! snoRNA processing
is_a: GO:0043628 ! ncRNA 3'-end processing

[Term]
id: GO:0031127
name: alpha-(1,2)-fucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->2) linkage." [GOC:mah]
subset: gosubset_prok
synonym: "alpha-(1->2)-fucosyltransferase activity" EXACT []
synonym: "alpha-1,2-fucosyltransferase activity" EXACT []
is_a: GO:0008417 ! fucosyltransferase activity

[Term]
id: GO:0031128
name: developmental induction
namespace: biological_process
def: "A developmental process involving two tissues in which one tissue (the inducer) produces a signal that directs cell fate commitment of cells in the second tissue (the responder)." [GOC:cjm, GOC:dph, GOC:mah, PMID:24503535]
is_a: GO:0032502 ! developmental process
intersection_of: GO:0032502 ! developmental process
intersection_of: has_part GO:0045168 ! cell-cell signaling involved in cell fate commitment
relationship: has_part GO:0045168 ! cell-cell signaling involved in cell fate commitment

[Term]
id: GO:0031129
name: inductive cell-cell signaling
namespace: biological_process
def: "Signaling at short range between cells of different ancestry and developmental potential that results in one cell or group of cells effecting a developmental change in the other. This is often done by secretion of proteins by one cell which affects the neighboring cells and causes them to adopt a certain fate." [GOC:mah]
synonym: "inductive cell-cell signalling" EXACT []
is_a: GO:0031128 ! developmental induction

[Term]
id: GO:0031130
name: creation of an inductive signal
namespace: biological_process
def: "The process in which one cell or group of cells sends a signal over a short range to another cell or group of cells of different ancestry and developmental potential, thereby effecting a developmental change in the latter." [GOC:mah]
is_a: GO:0048869 ! cellular developmental process
relationship: part_of GO:0031129 ! inductive cell-cell signaling

[Term]
id: GO:0031131
name: reception of an inductive signal
namespace: biological_process
def: "The process in which one cell or group of cells receives, transduces, and responds to a signal generated by another cell or group of cells of different ancestry and developmental potential, such that the recipient cell(s) undergo a developmental change." [GOC:mah]
is_a: GO:0031668 ! cellular response to extracellular stimulus
relationship: part_of GO:0031129 ! inductive cell-cell signaling

[Term]
id: GO:0031132
name: serine 3-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-serine + NADP(+) = L-alpha-formylglycine + 2 H(+) + NADPH." [EC:1.1.1.276, RHEA:21599]
synonym: "L-serine:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.276]
xref: EC:1.1.1.276
xref: KEGG:R06126
xref: MetaCyc:RXN0-2201
xref: RHEA:21599
xref: Wikipedia:Serine_3-dehydrogenase
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0031133
name: regulation of axon diameter
namespace: biological_process
def: "Any process that modulates the rate, direction or extent of axon growth such that the correct diameter is attained and maintained." [GOC:dph, GOC:mah, GOC:tb]
is_a: GO:0032536 ! regulation of cell projection size
is_a: GO:0050770 ! regulation of axonogenesis

[Term]
id: GO:0031134
name: sister chromatid biorientation
namespace: biological_process
def: "The cell cycle process in which sister chromatids establish stable attachments to microtubules emanating from opposite spindle poles." [PMID:15309047]
synonym: "chromosome biorientation" EXACT []
synonym: "sister kinetochore biorientation" EXACT []
is_a: GO:0008608 ! attachment of spindle microtubules to kinetochore
relationship: part_of GO:0000819 ! sister chromatid segregation

[Term]
id: GO:0031135
name: negative regulation of conjugation
namespace: biological_process
def: "Any process that decreases the rate of conjugation." [GOC:mah]
synonym: "down regulation of conjugation" EXACT []
synonym: "down-regulation of conjugation" EXACT []
synonym: "downregulation of conjugation" EXACT []
synonym: "inhibition of conjugation" NARROW []
is_a: GO:0043901 ! negative regulation of multi-organism process
is_a: GO:0046999 ! regulation of conjugation
is_a: GO:0048523 ! negative regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000746 ! conjugation
relationship: negatively_regulates GO:0000746 ! conjugation

[Term]
id: GO:0031136
name: positive regulation of conjugation
namespace: biological_process
def: "Any process that increases the rate or frequency of conjugation." [GOC:mah]
synonym: "activation of conjugation" NARROW []
synonym: "stimulation of conjugation" NARROW []
synonym: "up regulation of conjugation" EXACT []
synonym: "up-regulation of conjugation" EXACT []
synonym: "upregulation of conjugation" EXACT []
is_a: GO:0043902 ! positive regulation of multi-organism process
is_a: GO:0046999 ! regulation of conjugation
is_a: GO:0048522 ! positive regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000746 ! conjugation
relationship: positively_regulates GO:0000746 ! conjugation

[Term]
id: GO:0031137
name: regulation of conjugation with cellular fusion
namespace: biological_process
def: "Any process that modulates the rate or frequency of conjugation with cellular fusion." [GOC:mah]
is_a: GO:0046999 ! regulation of conjugation
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000747 ! conjugation with cellular fusion
relationship: regulates GO:0000747 ! conjugation with cellular fusion

[Term]
id: GO:0031138
name: negative regulation of conjugation with cellular fusion
namespace: biological_process
def: "Any process that decreases the rate or frequency of conjugation with cellular fusion." [GOC:mah]
synonym: "down regulation of conjugation with cellular fusion" EXACT []
synonym: "down-regulation of conjugation with cellular fusion" EXACT []
synonym: "downregulation of conjugation with cellular fusion" EXACT []
synonym: "inhibition of conjugation with cellular fusion" NARROW []
is_a: GO:0031135 ! negative regulation of conjugation
is_a: GO:0031137 ! regulation of conjugation with cellular fusion
is_a: GO:2000242 ! negative regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000747 ! conjugation with cellular fusion
relationship: negatively_regulates GO:0000747 ! conjugation with cellular fusion

[Term]
id: GO:0031139
name: positive regulation of conjugation with cellular fusion
namespace: biological_process
def: "Any process that increases the rate or frequency of conjugation with cellular fusion." [GOC:mah]
synonym: "activation of conjugation with cellular fusion" NARROW []
synonym: "stimulation of conjugation with cellular fusion" NARROW []
synonym: "up regulation of conjugation with cellular fusion" EXACT []
synonym: "up-regulation of conjugation with cellular fusion" EXACT []
synonym: "upregulation of conjugation with cellular fusion" EXACT []
is_a: GO:0031136 ! positive regulation of conjugation
is_a: GO:0031137 ! regulation of conjugation with cellular fusion
is_a: GO:2000243 ! positive regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000747 ! conjugation with cellular fusion
relationship: positively_regulates GO:0000747 ! conjugation with cellular fusion

[Term]
id: GO:0031140
name: induction of conjugation upon nutrient starvation
namespace: biological_process
def: "The process in which a cell initiates conjugation with cellular fusion upon starvation for one or more nutrients." [GOC:mah]
is_a: GO:0010514 ! induction of conjugation with cellular fusion

[Term]
id: GO:0031141
name: induction of conjugation upon carbon starvation
namespace: biological_process
def: "The process in which a cell initiates conjugation with cellular fusion upon carbon starvation." [GOC:mah]
is_a: GO:0031140 ! induction of conjugation upon nutrient starvation

[Term]
id: GO:0031142
name: induction of conjugation upon nitrogen starvation
namespace: biological_process
def: "The process in which a cell initiates conjugation with cellular fusion upon nitrogen starvation." [GOC:mah]
is_a: GO:0006995 ! cellular response to nitrogen starvation
is_a: GO:0031140 ! induction of conjugation upon nutrient starvation

[Term]
id: GO:0031143
name: pseudopodium
namespace: cellular_component
def: "A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding." [ISBN:0198506732]
subset: goslim_pir
synonym: "pseudopod" EXACT []
xref: Wikipedia:Pseudopod
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0031144
name: proteasome localization
namespace: biological_process
def: "Any process in which the proteasome is transported to, or maintained in, a specific location." [GOC:mah]
synonym: "establishment and maintenance of proteasome localization" EXACT []
synonym: "proteasome localisation" EXACT [GOC:mah]
is_a: GO:0034629 ! cellular protein complex localization

[Term]
id: GO:0031145
name: anaphase-promoting complex-dependent catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome." [PMID:15380083]
synonym: "anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein breakdown" EXACT []
synonym: "anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process" EXACT []
synonym: "anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolism" EXACT []
synonym: "anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein degradation" EXACT []
synonym: "APC-dependent proteasomal ubiquitin-dependent protein catabolic process" EXACT []
synonym: "APC-dependent proteasomal ubiquitin-dependent protein catabolism" EXACT []
xref: Reactome:REACT_100663 "Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Bos taurus"
xref: Reactome:REACT_101977 "APC/C:Cdc20 mediated degradation of Securin, Gallus gallus"
xref: Reactome:REACT_102545 "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, Danio rerio"
xref: Reactome:REACT_103142 "APC/C:Cdc20 mediated degradation of Securin, Danio rerio"
xref: Reactome:REACT_105318 "APC/C-mediated degradation of cell cycle proteins, Danio rerio"
xref: Reactome:REACT_105606 "APC/C:Cdc20 mediated degradation of Securin, Bos taurus"
xref: Reactome:REACT_106319 "APC/C-mediated degradation of cell cycle proteins, Bos taurus"
xref: Reactome:REACT_107060 "Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Mus musculus"
xref: Reactome:REACT_107295 "APC/C-mediated degradation of cell cycle proteins, Dictyostelium discoideum"
xref: Reactome:REACT_107739 "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, Rattus norvegicus"
xref: Reactome:REACT_108841 "APC/C:Cdc20 mediated degradation of Securin, Canis familiaris"
xref: Reactome:REACT_109136 "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, Gallus gallus"
xref: Reactome:REACT_109907 "APC/C:Cdc20 mediated degradation of Securin, Mus musculus"
xref: Reactome:REACT_114974 "Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Oryza sativa"
xref: Reactome:REACT_28946 "Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Rattus norvegicus"
xref: Reactome:REACT_29102 "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, Arabidopsis thaliana"
xref: Reactome:REACT_29126 "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, Xenopus tropicalis"
xref: Reactome:REACT_30638 "APC/C:Cdc20 mediated degradation of Cyclin B, Mus musculus"
xref: Reactome:REACT_30862 "Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Taeniopygia guttata"
xref: Reactome:REACT_31169 "APC/C-mediated degradation of cell cycle proteins, Canis familiaris"
xref: Reactome:REACT_31635 "APC/C-mediated degradation of cell cycle proteins, Mus musculus"
xref: Reactome:REACT_33104 "APC/C:Cdc20 mediated degradation of Cyclin B, Drosophila melanogaster"
xref: Reactome:REACT_33354 "APC/C:Cdc20 mediated degradation of Cyclin B, Rattus norvegicus"
xref: Reactome:REACT_33804 "APC/C:Cdc20 mediated degradation of Cyclin B, Canis familiaris"
xref: Reactome:REACT_34466 "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, Oryza sativa"
xref: Reactome:REACT_6761 "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, Homo sapiens"
xref: Reactome:REACT_6820 "APC/C:Cdc20 mediated degradation of Cyclin B, Homo sapiens"
xref: Reactome:REACT_6828 "APC/C-mediated degradation of cell cycle proteins, Homo sapiens"
xref: Reactome:REACT_6850 "Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Homo sapiens"
xref: Reactome:REACT_6871 "APC/C:Cdc20 mediated degradation of Securin, Homo sapiens"
xref: Reactome:REACT_77053 "APC/C-mediated degradation of cell cycle proteins, Drosophila melanogaster"
xref: Reactome:REACT_77598 "Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Gallus gallus"
xref: Reactome:REACT_78404 "APC/C-mediated degradation of cell cycle proteins, Rattus norvegicus"
xref: Reactome:REACT_79226 "Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Xenopus tropicalis"
xref: Reactome:REACT_80456 "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, Taeniopygia guttata"
xref: Reactome:REACT_82008 "Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Drosophila melanogaster"
xref: Reactome:REACT_82654 "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, Bos taurus"
xref: Reactome:REACT_82931 "APC/C-mediated degradation of cell cycle proteins, Gallus gallus"
xref: Reactome:REACT_82967 "APC/C-mediated degradation of cell cycle proteins, Saccharomyces cerevisiae"
xref: Reactome:REACT_83315 "Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Canis familiaris"
xref: Reactome:REACT_83601 "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, Dictyostelium discoideum"
xref: Reactome:REACT_83629 "APC/C-mediated degradation of cell cycle proteins, Sus scrofa"
xref: Reactome:REACT_84389 "APC/C:Cdc20 mediated degradation of Cyclin B, Xenopus tropicalis"
xref: Reactome:REACT_85764 "APC/C-mediated degradation of cell cycle proteins, Schizosaccharomyces pombe"
xref: Reactome:REACT_85884 "APC/C:Cdc20 mediated degradation of Securin, Rattus norvegicus"
xref: Reactome:REACT_87631 "APC/C:Cdc20 mediated degradation of Cyclin B, Bos taurus"
xref: Reactome:REACT_88649 "APC/C-mediated degradation of cell cycle proteins, Xenopus tropicalis"
xref: Reactome:REACT_88839 "APC/C:Cdc20 mediated degradation of Cyclin B, Danio rerio"
xref: Reactome:REACT_89282 "APC/C:Cdc20 mediated degradation of Cyclin B, Taeniopygia guttata"
xref: Reactome:REACT_89743 "Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Danio rerio"
xref: Reactome:REACT_89823 "APC/C-mediated degradation of cell cycle proteins, Oryza sativa"
xref: Reactome:REACT_91593 "APC/C:Cdc20 mediated degradation of Securin, Xenopus tropicalis"
xref: Reactome:REACT_91603 "APC/C:Cdc20 mediated degradation of Cyclin B, Gallus gallus"
xref: Reactome:REACT_91805 "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, Canis familiaris"
xref: Reactome:REACT_92044 "APC/C:Cdc20 mediated degradation of Securin, Drosophila melanogaster"
xref: Reactome:REACT_92767 "APC/C-mediated degradation of cell cycle proteins, Taeniopygia guttata"
xref: Reactome:REACT_94396 "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, Drosophila melanogaster"
xref: Reactome:REACT_95731 "APC/C-mediated degradation of cell cycle proteins, Arabidopsis thaliana"
xref: Reactome:REACT_97054 "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, Mus musculus"
xref: Reactome:REACT_97523 "APC/C:Cdc20 mediated degradation of Securin, Taeniopygia guttata"
is_a: GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process

[Term]
id: GO:0031146
name: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083]
synonym: "SCF-dependent proteasomal ubiquitin-dependent protein breakdown" EXACT []
synonym: "SCF-dependent proteasomal ubiquitin-dependent protein catabolism" EXACT []
synonym: "SCF-dependent proteasomal ubiquitin-dependent protein degradation" EXACT []
is_a: GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process

[Term]
id: GO:0031147
name: 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one, also known as DIF-1, differentiation-inducing factor-1. DIF-1 is a secreted chlorinated molecule that controls cell fate during development of Dictyostelium cells." [GOC:mah, PMID:10706822]
synonym: "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one metabolism" EXACT []
synonym: "DIF-1 metabolic process" EXACT []
synonym: "DIF-1 metabolism" EXACT []
is_a: GO:0018904 ! ether metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0042180 ! cellular ketone metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:0031148
name: DIF-1 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one, also known as DIF-1, differentiation-inducing factor-1. DIF-1 is a secreted chlorinated molecule that controls cell fate during development of Dictyostelium cells." [GOC:mah, PMID:10706822]
synonym: "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one anabolism" EXACT []
synonym: "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one biosynthesis" EXACT []
synonym: "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one biosynthetic process" EXACT []
synonym: "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one formation" EXACT []
synonym: "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one synthesis" EXACT []
synonym: "DIF-1 biosynthesis" EXACT []
is_a: GO:0031147 ! 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one metabolic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:1901503 ! ether biosynthetic process

[Term]
id: GO:0031149
name: sorocarp stalk cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a sorocarp stalk cell, any of the cellulose-covered cells that form the stalk of a sorocarp. An example of this process is found in Dictyostelium discoideum." [dictyBase_REF:5048, GOC:mah, GOC:mtg_sensu, ISBN:0521583640]
synonym: "stalk cell differentiation" EXACT []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0030154 ! cell differentiation
is_a: GO:0044702 ! single organism reproductive process
relationship: part_of GO:0031150 ! sorocarp stalk development

[Term]
id: GO:0031150
name: sorocarp stalk development
namespace: biological_process
def: "The process whose specific outcome is the progression of the sorocarp stalk over time, from its formation to the mature structure. The sorocarp stalk is a tubular structure that consists of cellulose-covered cells stacked on top of each other and surrounded by an acellular stalk tube composed of cellulose and glycoprotein. An example of this process is found in Dictyostelium discoideum." [dictyBase_REF:5048, GOC:mtg_sensu, ISBN:0521583640]
synonym: "sorophore development" EXACT []
synonym: "stalk development" BROAD []
synonym: "stalk formation" BROAD []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0031154 ! culmination involved in sorocarp development

[Term]
id: GO:0031151
name: histone methyltransferase activity (H3-K79 specific)
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 79) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 79). This reaction is the addition of a methyl group onto lysine at position 79 of the histone H3 protein." [GOC:mah, PMID:15371351]
synonym: "histone lysine N-methyltransferase activity (H3-K79 specific)" EXACT []
synonym: "histone methylase activity (H3-K79 specific)" EXACT [GOC:mah]
is_a: GO:0018024 ! histone-lysine N-methyltransferase activity
relationship: part_of GO:0034729 ! histone H3-K79 methylation

[Term]
id: GO:0031152
name: aggregation involved in sorocarp development
namespace: biological_process
def: "The process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug." [GOC:mah, GOC:mtg_sensu, ISBN:0521583640]
synonym: "aggregate development involved in sorocarp development" EXACT []
synonym: "aggregation during fruiting body development" EXACT []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0030587 ! sorocarp development

[Term]
id: GO:0031153
name: slug development involved in sorocarp development
namespace: biological_process
def: "The process whose specific outcome is the progression of the slug over time, from its formation to the mature structure. Slug development begins when the aggregate rises upwards to form a finger-shaped structure and ends when culmination begins. Slug development begins after aggregation and ends before culmination in sorocarp development." [GOC:mah, GOC:mtg_sensu, ISBN:0521583640]
synonym: "migratory slug development during sorocarp development" NARROW []
synonym: "pseudoplasmodium biosynthesis" EXACT []
synonym: "pseudoplasmodium formation" EXACT []
synonym: "slug development during fruiting body development" EXACT []
synonym: "slug development during sorocarp development" RELATED [GOC:dph, GOC:tb]
synonym: "standing slug development during sorocarp development" NARROW []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0030587 ! sorocarp development

[Term]
id: GO:0031154
name: culmination involved in sorocarp development
namespace: biological_process
def: "The process whose specific outcome is the progression of the culminant over time, from its formation to the mature structure. Culmination begins with a morphogenetic change of the finger-like or migratory slug giving rise to an organized structure containing a stalk and a sorus. This process is the final stage of sorocarp development." [GOC:mah, GOC:mtg_sensu, ISBN:0521583640]
synonym: "culminant development" EXACT []
synonym: "culmination during fruiting body development" EXACT []
synonym: "culmination during sorocarp development" RELATED []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0030587 ! sorocarp development

[Term]
id: GO:0031155
name: regulation of fruiting body development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fruiting body development." [GOC:mah]
synonym: "regulation of fruiting body formation" EXACT []
is_a: GO:0075260 ! regulation of spore-bearing organ development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030582 ! fruiting body development
relationship: regulates GO:0030582 ! fruiting body development

[Term]
id: GO:0031156
name: regulation of sorocarp development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sorocarp development. An example of this process is found in Dictyostelium discoideum." [dictyBase_REF:2530, GOC:mah, GOC:mtg_sensu]
synonym: "regulation of fruiting body development" BROAD []
synonym: "regulation of fruiting body formation" BROAD []
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0031155 ! regulation of fruiting body development
is_a: GO:0032107 ! regulation of response to nutrient levels
is_a: GO:0080135 ! regulation of cellular response to stress
is_a: GO:1903664 ! regulation of asexual reproduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030587 ! sorocarp development
relationship: regulates GO:0030587 ! sorocarp development

[Term]
id: GO:0031157
name: regulation of aggregate size involved in sorocarp development
namespace: biological_process
def: "Any process that modulates the size of the aggregate formed during sorocarp formation." [dictyBase_REF:5048, GOC:mah, GOC:mtg_sensu, GOC:pg]
synonym: "regulation of aggregation during fruiting body biosynthesis" RELATED []
synonym: "regulation of aggregation during fruiting body formation" RELATED []
is_a: GO:0060176 ! regulation of aggregation involved in sorocarp development
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0031158
name: negative regulation of aggregate size involved in sorocarp development
namespace: biological_process
def: "Any process that decreases the size of the aggregate formed during sorocarp formation." [dictyBase_REF:5048, GOC:mah, GOC:mtg_sensu, GOC:pg]
synonym: "down regulation of aggregate size" EXACT []
synonym: "down-regulation of aggregate size" EXACT []
synonym: "downregulation of aggregate size" EXACT []
synonym: "inhibition of aggregate size" NARROW []
is_a: GO:0031157 ! regulation of aggregate size involved in sorocarp development

[Term]
id: GO:0031159
name: positive regulation of aggregate size involved in sorocarp development
namespace: biological_process
def: "Any process that increases the size of the aggregate formed during sorocarp formation." [dictyBase_REF:5048, GOC:mah, GOC:pg]
synonym: "activation of aggregate size" NARROW []
synonym: "stimulation of aggregate size" NARROW []
synonym: "up regulation of aggregate size" EXACT []
synonym: "up-regulation of aggregate size" EXACT []
synonym: "upregulation of aggregate size" EXACT []
is_a: GO:0031157 ! regulation of aggregate size involved in sorocarp development

[Term]
id: GO:0031160
name: spore wall
namespace: cellular_component
def: "The specialized envelope lying outside the cell membrane of a spore." [GOC:mah, GOC:pg]
synonym: "spore coat" EXACT []
is_a: GO:0005618 ! cell wall

[Term]
id: GO:0031161
name: phosphatidylinositol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [GOC:mah]
synonym: "phosphatidylinositol breakdown" EXACT []
synonym: "phosphatidylinositol catabolism" EXACT []
synonym: "phosphatidylinositol degradation" EXACT []
synonym: "PtdIns catabolic process" EXACT []
synonym: "PtdIns catabolism" EXACT []
is_a: GO:0046475 ! glycerophospholipid catabolic process
is_a: GO:0046488 ! phosphatidylinositol metabolic process

[Term]
id: GO:0031162
name: sulfur incorporation into metallo-sulfur cluster
namespace: biological_process
def: "The incorporation of exogenous sulfur into a metallo-sulfur cluster." [GOC:mah]
synonym: "sulphur incorporation into metallo-sulphur cluster" EXACT []
is_a: GO:0006464 ! cellular protein modification process
is_a: GO:0006790 ! sulfur compound metabolic process
relationship: part_of GO:0031163 ! metallo-sulfur cluster assembly

[Term]
id: GO:0031163
name: metallo-sulfur cluster assembly
namespace: biological_process
def: "The incorporation of a metal and exogenous sulfur into a metallo-sulfur cluster." [GOC:jl, GOC:mah, GOC:pde, GOC:vw]
subset: gosubset_prok
synonym: "metal-sulfur cluster assembly" EXACT [GOC:pr]
synonym: "metallo-sulfur cluster biosynthesis" RELATED []
synonym: "metallo-sulphur cluster assembly" EXACT []
is_a: GO:0022607 ! cellular component assembly

[Term]
id: GO:0031164
name: contractile vacuolar membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the contractile vacuole." [GOC:pg]
synonym: "contractile vacuole membrane" EXACT [GOC:mah, GOC:pf]
is_a: GO:0005774 ! vacuolar membrane
is_a: GO:0044433 ! cytoplasmic vesicle part
relationship: part_of GO:0000331 ! contractile vacuole

[Term]
id: GO:0031165
name: integral component of contractile vacuolar membrane
namespace: cellular_component
def: "The component of the contractile vacuolar membrane consisting of gene products that have some part that penetrates at least one leaflet of the membrane bilayer. This component includes gene products that are buried in the bilayer with no exposure outside the bilayer." [GOC:dos, GOC:pg]
synonym: "integral to contractile vacuolar membrane" EXACT []
is_a: GO:0031166 ! integral component of vacuolar membrane
is_a: GO:0031311 ! intrinsic component of contractile vacuolar membrane
intersection_of: GO:0016021 ! integral component of membrane
intersection_of: part_of GO:0031164 ! contractile vacuolar membrane
relationship: part_of GO:0031164 ! contractile vacuolar membrane

[Term]
id: GO:0031166
name: integral component of vacuolar membrane
namespace: cellular_component
def: "The component of the vacuolar membrane consisting of gene products and protein complexes that have some part that penetrates at least one leaflet of the membrane bilayer. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:dos, GOC:mah]
synonym: "integral to vacuolar membrane" NARROW []
is_a: GO:0031301 ! integral component of organelle membrane
is_a: GO:0031310 ! intrinsic component of vacuolar membrane
intersection_of: GO:0016021 ! integral component of membrane
intersection_of: part_of GO:0005774 ! vacuolar membrane
relationship: part_of GO:0005774 ! vacuolar membrane

[Term]
id: GO:0031167
name: rRNA methylation
namespace: biological_process
def: "The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule." [GOC:mah]
is_a: GO:0000154 ! rRNA modification
is_a: GO:0001510 ! RNA methylation

[Term]
id: GO:0031168
name: ferrichrome metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a ferrichrome. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine." [GOC:mah, ISBN:0198506732]
synonym: "ferrichrome metabolism" EXACT []
is_a: GO:0006518 ! peptide metabolic process
is_a: GO:0009237 ! siderophore metabolic process

[Term]
id: GO:0031169
name: ferrichrome biosynthetic process
namespace: biological_process
alt_id: GO:0031199
alt_id: GO:0031200
def: "The chemical reactions and pathways resulting in the formation of a ferrichrome. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine." [GOC:mah, ISBN:0198506732]
synonym: "ferrichrome anabolism" EXACT []
synonym: "ferrichrome biosynthesis" EXACT []
synonym: "ferrichrome biosynthetic process, peptide formation" NARROW []
synonym: "ferrichrome biosynthetic process, peptide modification" NARROW []
synonym: "ferrichrome formation" EXACT []
synonym: "ferrichrome synthesis" EXACT []
is_a: GO:0019539 ! siderophore biosynthetic process from hydroxamic acid
is_a: GO:0031168 ! ferrichrome metabolic process

[Term]
id: GO:0031170
name: ferricrocin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ferricrocin, a cyclic hexapeptide siderophore with the structure Gly-Ser-Gly-(N5-acetyl-N5-hydroxyornithine)3." [GOC:mah, PMID:12828635]
synonym: "ferricrocin metabolism" EXACT []
is_a: GO:0031168 ! ferrichrome metabolic process

[Term]
id: GO:0031171
name: ferricrocin biosynthetic process
namespace: biological_process
alt_id: GO:0031185
alt_id: GO:0031186
def: "The chemical reactions and pathways resulting in the formation of ferricrocin, a cyclic hexapeptide siderophore with the structure Gly-Ser-Gly-(N5-acetyl-N5-hydroxyornithine)3." [GOC:mah, PMID:12828635]
synonym: "ferricrocin anabolism" EXACT []
synonym: "ferricrocin biosynthesis" EXACT []
synonym: "ferricrocin biosynthetic process, peptide formation" NARROW []
synonym: "ferricrocin biosynthetic process, peptide modification" NARROW []
synonym: "ferricrocin formation" EXACT []
synonym: "ferricrocin synthesis" EXACT []
is_a: GO:0031169 ! ferrichrome biosynthetic process
is_a: GO:0031170 ! ferricrocin metabolic process

[Term]
id: GO:0031172
name: ornithine N5-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-ornithine + O2 + H+ = N5-hydroxy-L-ornithine + H2O." [MetaCyc:RXN-11128, PMID:12828635]
synonym: "L-ornithine 5-monooxygenase activity" EXACT [MetaCyc:RXN-11128]
xref: MetaCyc:RXN-11128
is_a: GO:0004497 ! monooxygenase activity

[Term]
id: GO:0031173
name: otolith mineralization completed early in development
namespace: biological_process
def: "The formation of otoliths during embryogenesis with completion in early postembryonic development. Formation occurs by precipitation of specific crystal forms of calcium carbonate around an organic core of extracellular matrix proteins. Otoconia (otoliths) are small (~10 micron) dense extracellular particles present in the otolith end organs of the vertebrate inner ear." [GOC:dsf, PMID:15581873]
synonym: "otoconia mineralization" EXACT []
synonym: "otoconium mineralization" EXACT []
is_a: GO:0045299 ! otolith mineralization

[Term]
id: GO:0031174
name: lifelong otolith mineralization
namespace: biological_process
def: "The formation and growth of otoliths throughout the life of the organism. Otoliths are the large extracellular ear-stones of the fish inner ear, produced by precipitation of specific crystal forms of calcium carbonate on organic matrices. The otolith enlarges throughout the life of the fish, as layers of calcium carbonate are added." [GOC:dsf, PMID:15581873]
is_a: GO:0045299 ! otolith mineralization

[Term]
id: GO:0031175
name: neuron projection development
namespace: biological_process
def: "The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:mah]
synonym: "neurite biosynthesis" NARROW []
synonym: "neurite development" NARROW [GOC:dph]
synonym: "neurite formation" NARROW []
synonym: "neurite growth" NARROW []
synonym: "neurite outgrowth" NARROW []
is_a: GO:0030030 ! cell projection organization
relationship: part_of GO:0048666 ! neuron development

[Term]
id: GO:0031176
name: endo-1,4-beta-xylanase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans." [EC:3.2.1.8]
synonym: "1,4-beta-D-xylan xylanohydrolase activity" EXACT [EC:3.2.1.8]
synonym: "1,4-beta-xylan xylanohydrolase activity" EXACT [EC:3.2.1.8]
synonym: "beta-1,4-xylan xylanohydrolase activity" EXACT [EC:3.2.1.8]
synonym: "beta-1,4-xylanase activity" EXACT [EC:3.2.1.8]
synonym: "beta-D-xylanase activity" EXACT [EC:3.2.1.8]
synonym: "beta-xylanase activity" EXACT [EC:3.2.1.8]
synonym: "endo-(1,4)-beta-xylanase(1,4)-beta-xylan 4-xylanohydrolase activity" EXACT [EC:3.2.1.8]
synonym: "endo-(1->4)-beta-xylanase(1->4)-beta-xylan 4-xylanohydrolase activity" EXACT [EC:3.2.1.8]
synonym: "endo-1,4-beta-D-xylanase activity" EXACT [EC:3.2.1.8]
synonym: "endo-1,4-xylanase activity" EXACT [EC:3.2.1.8]
synonym: "endo-beta-1,4-xylanase activity" EXACT [EC:3.2.1.8]
synonym: "xylanase" BROAD [EC:3.2.1.8]
xref: EC:3.2.1.8
xref: MetaCyc:3.2.1.8-RXN
is_a: GO:0097599 ! xylanase activity

[Term]
id: GO:0031177
name: phosphopantetheine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate)." [CHEBI:16858, GOC:mah, GOC:vw]
is_a: GO:0019842 ! vitamin binding
is_a: GO:0033218 ! amide binding
is_a: GO:0043168 ! anion binding
is_a: GO:0072341 ! modified amino acid binding

[Term]
id: GO:0031179
name: peptide modification
namespace: biological_process
def: "The covalent alteration of one or more amino acid residues within a peptide, resulting in a change in the properties of that peptide." [GOC:mah]
subset: gosubset_prok
is_a: GO:0006518 ! peptide metabolic process

[Term]
id: GO:0031201
name: SNARE complex
namespace: cellular_component
def: "A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25." [GOC:bhm, GOC:pr, PMID:10872468, PMID:19450911]
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0098796 ! membrane protein complex

[Term]
id: GO:0031203
name: posttranslational protein targeting to membrane, docking
namespace: biological_process
def: "The process in which the signal sequence of a translated protein binds to and forms a complex with the Sec complex." [PMID:12518217, PMID:8707814]
synonym: "posttranslational protein membrane targeting, docking" EXACT []
synonym: "protein docking during posttranslational protein targeting to membrane" EXACT []
synonym: "Sec-translated protein complex assembly" EXACT []
is_a: GO:0043623 ! cellular protein complex assembly
relationship: part_of GO:0006620 ! posttranslational protein targeting to membrane

[Term]
id: GO:0031204
name: posttranslational protein targeting to membrane, translocation
namespace: biological_process
def: "The process in which a protein translocates through the ER membrane posttranslationally." [PMID:12518317, PMID:8707814]
synonym: "posttranslational protein membrane targeting, translocation" EXACT []
synonym: "protein translocation during posttranslational protein targeting to membrane" EXACT []
is_a: GO:0065002 ! intracellular protein transmembrane transport
relationship: part_of GO:0006620 ! posttranslational protein targeting to membrane

[Term]
id: GO:0031205
name: endoplasmic reticulum Sec complex
namespace: cellular_component
def: "An endoplasmic reticulum membrane-associated complex involved in the translocation of proteins that are targeted to the ER. In yeast, this complex consists of two subcomplexes, namely, the Sec61 complex and the Sec62/Sec63 complex." [GOC:mtg_sensu, PMID:12158317, PMID:14617809]
subset: goslim_pir
is_a: GO:0044432 ! endoplasmic reticulum part
is_a: GO:0098796 ! membrane protein complex
relationship: has_part GO:0005784 ! Sec61 translocon complex
relationship: part_of GO:0030867 ! rough endoplasmic reticulum membrane

[Term]
id: GO:0031207
name: Sec62/Sec63 complex
namespace: cellular_component
def: "A protein complex involved in the posttranslational targeting of proteins to the ER. In yeast, it is a tetrameric complex consisting of Sec62p, Sec63p, Sec71p and Sec72p." [PMID:12518317, PMID:14617809]
synonym: "ER protein translocation subcomplex" EXACT []
synonym: "Sec62/63 complex" EXACT []
is_a: GO:0044432 ! endoplasmic reticulum part
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0031205 ! endoplasmic reticulum Sec complex

[Term]
id: GO:0031208
name: POZ domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a POZ (poxvirus and zinc finger) domain of a protein, a protein-protein interaction domain found in many transcription factors." [PMID:7958847]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0031209
name: SCAR complex
namespace: cellular_component
def: "A heterotetrameric complex that includes orthologues of human PIR121, Nap125 and HSPC300 and regulates actin polymerization and/or depolymerization through small GTPase mediated signal transduction." [GOC:pg, PMID:12181570]
synonym: "WAVE complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0031210
name: phosphatidylcholine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with phosphatidylcholine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:mah, ISBN:0198506732]
is_a: GO:0005543 ! phospholipid binding
is_a: GO:0043178 ! alcohol binding
is_a: GO:0050997 ! quaternary ammonium group binding
is_a: GO:0070405 ! ammonium ion binding

[Term]
id: GO:0031211
name: endoplasmic reticulum palmitoyltransferase complex
namespace: cellular_component
def: "A complex of the endoplasmic reticulum that catalyzes S-palmitoylation, the addition of palmitate (C16:0) or other long-chain fatty acids to proteins at a cysteine residue." [GOC:jh]
is_a: GO:0002178 ! palmitoyltransferase complex
is_a: GO:0044432 ! endoplasmic reticulum part
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane

[Term]
id: GO:0031213
name: RSF complex
namespace: cellular_component
def: "An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals) and an RSF1 homolog. It mediates nucleosome deposition and generates regularly spaced nucleosome arrays. In mammals, RSF is involved in regulation of transcription from RNA polymerase II promoters)." [GOC:krc, PMID:12972596, PMID:15284901, PMID:16568949, PMID:21810179]
synonym: "remodeling and spacing factor complex" EXACT []
is_a: GO:0031010 ! ISWI-type complex

[Term]
id: GO:0031214
name: biomineral tissue development
namespace: biological_process
def: "Formation of hard tissues that consist mainly of inorganic compounds, and also contain a small amounts of organic matrices that are believed to play important roles in their formation." [PMID:15132736]
synonym: "biomineral formation" RELATED [GOC:dph, GOC:tb]
synonym: "biomineralization" EXACT []
synonym: "mineralization" EXACT []
xref: Wikipedia:Biomineralisation
is_a: GO:0009888 ! tissue development
relationship: part_of GO:0048513 ! animal organ development

[Term]
id: GO:0031215
name: shell calcification
namespace: biological_process
def: "The precipitation of calcium carbonate onto the organic matrix of a shell, such as a mollusc shell." [GOC:mah, PMID:15132736]
is_a: GO:0031214 ! biomineral tissue development

[Term]
id: GO:0031216
name: neopullulanase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of pullulan to panose (6-alpha-D-glucosylmaltose)." [EC:3.2.1.135, GOC:mlg]
synonym: "pullulan 4-D-glucanohydrolase (panose-forming)" EXACT [EC:3.2.1.135]
synonym: "pullulanase II activity" EXACT []
xref: EC:3.2.1.135
xref: MetaCyc:3.2.1.135-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0031217
name: glucan 1,4-beta-glucosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1->4) linkages in (1->4)-beta-D-glucans, to remove successive glucose units." [EC:3.2.1.74, GOC:mlg]
synonym: "1,4-beta-D-glucan glucohydrolase activity" BROAD [EC:3.2.1.74]
synonym: "beta-1,4-beta-glucanase activity" BROAD [EC:3.2.1.74]
synonym: "beta-1,4-glucanase activity" BROAD []
synonym: "exo-1,4-beta-D-glucosidase activity" EXACT [EC:3.2.1.74]
synonym: "exo-1,4-beta-glucanase activity" EXACT []
synonym: "exo-1,4-beta-glucosidase activity" EXACT []
synonym: "exo-beta-1,4-glucanase activity" EXACT []
synonym: "exo-beta-1,4-glucosidase activity" EXACT []
synonym: "exocellulase activity" EXACT []
xref: EC:3.2.1.74
xref: MetaCyc:3.2.1.74-RXN
is_a: GO:0008422 ! beta-glucosidase activity

[Term]
id: GO:0031218
name: arabinogalactan endo-1,4-beta-galactosidase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of (1->4)-beta-D-galactosidic linkages in arabinogalactans." [EC:3.2.1.89, GOC:mlg]
synonym: "arabinogalactan 4-beta-D-galactanohydrolase activity" EXACT [EC:3.2.1.89]
synonym: "arabinogalactanase activity" EXACT []
synonym: "endo-1,4-beta-galactanase activity" EXACT []
synonym: "galactanase activity" EXACT []
xref: EC:3.2.1.89
xref: MetaCyc:3.2.1.89-RXN
is_a: GO:0015925 ! galactosidase activity

[Term]
id: GO:0031219
name: levanase activity
namespace: molecular_function
def: "Catalysis of the random hydrolysis of 2,6-beta-D-fructofuranosidic linkages in 2,6-beta-D-fructans (levans) containing more than 3 fructose units." [EC:3.2.1.65, GOC:mlg]
synonym: "2,6-beta-D-fructan fructanohydrolase activity" EXACT [EC:3.2.1.65]
synonym: "levan hydrolase activity" EXACT []
xref: EC:3.2.1.65
xref: MetaCyc:3.2.1.65-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0031220
name: maltodextrin phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: maltodextrin = glucose-1-phosphate." [GOC:mlg, PMID:10348846]
xref: MetaCyc:RXN-9025
xref: MetaCyc:RXN0-5182
is_a: GO:0004645 ! phosphorylase activity

[Term]
id: GO:0031221
name: arabinan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving arabinan, a polysaccharide composed of arabinose residues." [GOC:mlg, ISBN:0198506732]
synonym: "arabinan metabolism" EXACT []
is_a: GO:0005976 ! polysaccharide metabolic process
is_a: GO:0044723 ! single-organism carbohydrate metabolic process

[Term]
id: GO:0031222
name: arabinan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of arabinan, a polysaccharide composed of arabinose residues." [GOC:mlg, ISBN:0198506732]
synonym: "arabinan breakdown" EXACT []
synonym: "arabinan catabolism" EXACT []
synonym: "arabinan degradation" EXACT []
is_a: GO:0000272 ! polysaccharide catabolic process
is_a: GO:0031221 ! arabinan metabolic process
is_a: GO:0044724 ! single-organism carbohydrate catabolic process

[Term]
id: GO:0031223
name: auditory behavior
namespace: biological_process
def: "The behavior of an organism in response to a sound." [GOC:pr, GOC:rc]
synonym: "auditory behaviour" EXACT []
synonym: "behavioral response to sound" EXACT []
synonym: "behavioural response to sound" EXACT []
is_a: GO:0007638 ! mechanosensory behavior
relationship: part_of GO:0010996 ! response to auditory stimulus

[Term]
id: GO:0031224
name: intrinsic component of membrane
namespace: cellular_component
def: "The component of a membrane consisting of the gene products having some covalently attached portion, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, which spans or is embedded in one or both leaflets of the membrane." [GOC:mah]
comment: Note that proteins intrinsic to membranes cannot be removed without disrupting the membrane, e.g. by detergent.
subset: gosubset_prok
synonym: "intrinsic to membrane" NARROW []
is_a: GO:0044425 ! membrane part

[Term]
id: GO:0031225
name: anchored component of membrane
namespace: cellular_component
def: "The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:mah]
synonym: "anchored to membrane" EXACT []
is_a: GO:0031224 ! intrinsic component of membrane

[Term]
id: GO:0031226
name: intrinsic component of plasma membrane
namespace: cellular_component
def: "The component of the plasma membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
subset: gosubset_prok
synonym: "intrinsic to plasma membrane" NARROW []
is_a: GO:0031224 ! intrinsic component of membrane
is_a: GO:0044459 ! plasma membrane part
intersection_of: GO:0031224 ! intrinsic component of membrane
intersection_of: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0005886 ! plasma membrane

[Term]
id: GO:0031227
name: intrinsic component of endoplasmic reticulum membrane
namespace: cellular_component
def: "The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
synonym: "intrinsic to endoplasmic reticulum membrane" NARROW []
is_a: GO:0031300 ! intrinsic component of organelle membrane
is_a: GO:0044432 ! endoplasmic reticulum part
intersection_of: GO:0031224 ! intrinsic component of membrane
intersection_of: part_of GO:0005789 ! endoplasmic reticulum membrane
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane

[Term]
id: GO:0031228
name: intrinsic component of Golgi membrane
namespace: cellular_component
def: "The component of the Golgi membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
synonym: "intrinsic to Golgi membrane" NARROW []
is_a: GO:0031300 ! intrinsic component of organelle membrane
is_a: GO:0044431 ! Golgi apparatus part
intersection_of: GO:0031224 ! intrinsic component of membrane
intersection_of: part_of GO:0000139 ! Golgi membrane
relationship: part_of GO:0000139 ! Golgi membrane

[Term]
id: GO:0031229
name: intrinsic component of nuclear inner membrane
namespace: cellular_component
def: "The component of the nuclear inner membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
synonym: "intrinsic to nuclear inner membrane" NARROW []
is_a: GO:0031300 ! intrinsic component of organelle membrane
is_a: GO:0044453 ! nuclear membrane part
intersection_of: GO:0031224 ! intrinsic component of membrane
intersection_of: part_of GO:0005637 ! nuclear inner membrane
relationship: part_of GO:0005637 ! nuclear inner membrane

[Term]
id: GO:0031230
name: intrinsic component of cell outer membrane
namespace: cellular_component
def: "The component of the cell outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah, GOC:mtg_sensu]
subset: gosubset_prok
synonym: "intrinsic to cell outer membrane" NARROW []
is_a: GO:0031224 ! intrinsic component of membrane
is_a: GO:0044462 ! external encapsulating structure part
intersection_of: GO:0031224 ! intrinsic component of membrane
intersection_of: part_of GO:0009279 ! cell outer membrane
relationship: part_of GO:0009279 ! cell outer membrane

[Term]
id: GO:0031231
name: intrinsic component of peroxisomal membrane
namespace: cellular_component
def: "The component of the peroxisomal membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
synonym: "intrinsic to peroxisomal membrane" NARROW []
is_a: GO:0031300 ! intrinsic component of organelle membrane
is_a: GO:0044439 ! peroxisomal part
intersection_of: GO:0031224 ! intrinsic component of membrane
intersection_of: part_of GO:0005778 ! peroxisomal membrane
relationship: part_of GO:0005778 ! peroxisomal membrane

[Term]
id: GO:0031232
name: extrinsic component of external side of plasma membrane
namespace: cellular_component
def: "The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its external surface, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah]
synonym: "extrinsic to external leaflet of plasma membrane" EXACT [GOC:ab]
synonym: "extrinsic to external side of plasma membrane" NARROW []
is_a: GO:0019897 ! extrinsic component of plasma membrane
intersection_of: GO:0019898 ! extrinsic component of membrane
intersection_of: part_of GO:0009897 ! external side of plasma membrane
relationship: part_of GO:0009897 ! external side of plasma membrane

[Term]
id: GO:0031233
name: intrinsic component of external side of plasma membrane
namespace: cellular_component
def: "The component of a plasma membrane consisting of gene products and protein complexes that penetrate the external side of the plasma membrane only, either directly or via some covalently attached hydrophobic anchor." [GOC:dos, GOC:mah]
synonym: "intrinsic to external leaflet of plasma membrane" EXACT [GOC:ab]
synonym: "intrinsic to external side of plasma membrane" NARROW []
is_a: GO:0031226 ! intrinsic component of plasma membrane
intersection_of: GO:0031226 ! intrinsic component of plasma membrane
intersection_of: part_of GO:0009897 ! external side of plasma membrane
relationship: part_of GO:0009897 ! external side of plasma membrane

[Term]
id: GO:0031234
name: extrinsic component of cytoplasmic side of plasma membrane
namespace: cellular_component
def: "The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region." [GOC:mah]
comment: Consider also annotating to 'cell cortex ; GO:0005938'.
synonym: "extrinsic to cytoplasmic side of plasma membrane" NARROW []
synonym: "extrinsic to internal leaflet of plasma membrane" EXACT [GOC:ab]
synonym: "extrinsic to internal side of plasma membrane" EXACT []
is_a: GO:0019897 ! extrinsic component of plasma membrane
is_a: GO:0044424 ! intracellular part
intersection_of: GO:0019898 ! extrinsic component of membrane
intersection_of: part_of GO:0009898 ! cytoplasmic side of plasma membrane
relationship: part_of GO:0009898 ! cytoplasmic side of plasma membrane

[Term]
id: GO:0031235
name: intrinsic component of the cytoplasmic side of the plasma membrane
namespace: cellular_component
def: "The component of a plasma membrane consisting of gene products and protein complexes that have some covalently attached part (e.g. peptide sequence or GPI anchor) which is embedded in the cytoplasmic side of the plasma membrane only." [GOC:dos, GOC:mah]
synonym: "intrinsic to cytoplasmic side of plasma membrane" NARROW []
synonym: "intrinsic to internal leaflet of plasma membrane" EXACT [GOC:ab]
synonym: "intrinsic to internal side of plasma membrane" EXACT []
is_a: GO:0031226 ! intrinsic component of plasma membrane
intersection_of: GO:0031224 ! intrinsic component of membrane
intersection_of: part_of GO:0009898 ! cytoplasmic side of plasma membrane
relationship: part_of GO:0009898 ! cytoplasmic side of plasma membrane

[Term]
id: GO:0031236
name: extrinsic component of periplasmic side of plasma membrane
namespace: cellular_component
alt_id: GO:0031238
def: "The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its periplasmic surface, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah, GOC:mtg_sensu]
subset: gosubset_prok
synonym: "extrinsic to external leaflet of plasma membrane, in periplasmic space" NARROW [GOC:ab]
synonym: "extrinsic to external side of plasma membrane, in periplasmic space" NARROW []
is_a: GO:0031232 ! extrinsic component of external side of plasma membrane
is_a: GO:0044462 ! external encapsulating structure part
intersection_of: GO:0019898 ! extrinsic component of membrane
intersection_of: part_of GO:0098567 ! periplasmic side of plasma membrane
relationship: part_of GO:0098567 ! periplasmic side of plasma membrane

[Term]
id: GO:0031237
name: intrinsic component of periplasmic side of plasma membrane
namespace: cellular_component
alt_id: GO:0031239
def: "The component of a plasma membrane consisting of gene products and protein complexes that penetrate the periplasmic side of the plasma membrane only, either directly or via some covalently attached hydrophobic anchor." [GOC:mah, GOC:mtg_sensu]
subset: gosubset_prok
synonym: "intrinsic to external leaflet of plasma membrane, in periplasmic space" EXACT [GOC:ab]
synonym: "intrinsic to periplasmic side of plasma membrane" EXACT []
is_a: GO:0031233 ! intrinsic component of external side of plasma membrane
is_a: GO:0044462 ! external encapsulating structure part
intersection_of: GO:0031224 ! intrinsic component of membrane
intersection_of: part_of GO:0098567 ! periplasmic side of plasma membrane
relationship: part_of GO:0098567 ! periplasmic side of plasma membrane

[Term]
id: GO:0031240
name: external side of cell outer membrane
namespace: cellular_component
def: "The side of the outer membrane that is opposite to the side that faces the periplasm of the cell." [GOC:mlg, GOC:mtg_sensu]
comment: In GO, 'external side' still refers to part of the membrane and does not refer to components beyond (outside of) the membrane.
subset: gosubset_prok
synonym: "external leaflet of cell outer membrane" EXACT [GOC:ab]
synonym: "external side of outer membrane" RELATED []
is_a: GO:0044462 ! external encapsulating structure part
is_a: GO:0098552 ! side of membrane
relationship: part_of GO:0009279 ! cell outer membrane

[Term]
id: GO:0031241
name: periplasmic side of cell outer membrane
namespace: cellular_component
def: "The side (leaflet) of the outer membrane that faces the periplasm of the cell." [GOC:mlg, GOC:mtg_sensu]
comment: In GO, 'internal side' still refers to part of the membrane and does not refer to components beyond (inside of) the membrane.
subset: gosubset_prok
synonym: "internal leaflet of cell outer membrane" EXACT [GOC:ab]
synonym: "internal side of cell outer membrane" EXACT []
synonym: "internal side of outer membrane" EXACT []
is_a: GO:0044462 ! external encapsulating structure part
is_a: GO:0098552 ! side of membrane
relationship: part_of GO:0009279 ! cell outer membrane

[Term]
id: GO:0031242
name: extrinsic component of external side of cell outer membrane
namespace: cellular_component
def: "The component of a cell outer membrane consisting of gene products and protein complexes that are loosely bound to its external surface, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah, GOC:mtg_sensu]
subset: gosubset_prok
synonym: "extrinsic to external leaflet of cell outer membrane" EXACT [GOC:ab]
synonym: "extrinsic to external side of cell outer membrane" NARROW []
synonym: "extrinsic to external side of outer membrane" EXACT []
is_a: GO:0031244 ! extrinsic component of cell outer membrane
intersection_of: GO:0019898 ! extrinsic component of membrane
intersection_of: part_of GO:0031240 ! external side of cell outer membrane
relationship: part_of GO:0031240 ! external side of cell outer membrane

[Term]
id: GO:0031243
name: intrinsic component of external side of cell outer membrane
namespace: cellular_component
def: "The component of the cell outer membrane consisting of the gene products and protein complexes that penetrate the external side of the cell outer membrane only, either directly or via some covalently attached hydrophobic anchor." [GOC:dos, GOC:mah, GOC:mtg_sensu]
subset: gosubset_prok
synonym: "intrinsic to external leaflet of cell outer membrane" EXACT [GOC:ab]
synonym: "intrinsic to external side of cell outer membrane" NARROW []
synonym: "intrinsic to external side of outer membrane" EXACT []
is_a: GO:0031230 ! intrinsic component of cell outer membrane
intersection_of: GO:0031224 ! intrinsic component of membrane
intersection_of: part_of GO:0031240 ! external side of cell outer membrane
relationship: part_of GO:0031240 ! external side of cell outer membrane

[Term]
id: GO:0031244
name: extrinsic component of cell outer membrane
namespace: cellular_component
def: "The component of the cell outer membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah, GOC:mtg_sensu]
subset: gosubset_prok
synonym: "extrinsic to cell outer membrane" NARROW []
is_a: GO:0019898 ! extrinsic component of membrane
is_a: GO:0044462 ! external encapsulating structure part
intersection_of: GO:0019898 ! extrinsic component of membrane
intersection_of: part_of GO:0009279 ! cell outer membrane
relationship: part_of GO:0009279 ! cell outer membrane

[Term]
id: GO:0031245
name: extrinsic component of periplasmic side of cell outer membrane
namespace: cellular_component
def: "The component of the cell outer membrane consisting of gene products and protein complexes that are loosely bound to periplasmic surface, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah, GOC:mtg_sensu]
subset: gosubset_prok
synonym: "extrinsic to internal leaflet of cell outer membrane" NARROW [GOC:ab]
synonym: "extrinsic to internal side of cell outer membrane" EXACT []
synonym: "extrinsic to internal side of outer membrane" EXACT []
synonym: "extrinsic to periplasmic side of cell outer membrane" EXACT []
is_a: GO:0031244 ! extrinsic component of cell outer membrane
intersection_of: GO:0031244 ! extrinsic component of cell outer membrane
intersection_of: part_of GO:0031241 ! periplasmic side of cell outer membrane
relationship: part_of GO:0031241 ! periplasmic side of cell outer membrane

[Term]
id: GO:0031246
name: intrinsic component of periplasmic side of cell outer membrane
namespace: cellular_component
def: "The component of the cell outer membrane consisting of the gene products that that penetrate the periplasmic side of the cell outer membrane only, either directly or via some covalently attached hydrophobic anchor." [GOC:dos, GOC:mah, GOC:mtg_sensu]
subset: gosubset_prok
synonym: "intrinsic to external side of cell outer membrane" NARROW []
synonym: "intrinsic to internal leaflet of cell outer membrane" EXACT [GOC:ab]
synonym: "intrinsic to internal side of cell outer membrane" EXACT []
synonym: "intrinsic to internal side of outer membrane" EXACT []
is_a: GO:0031230 ! intrinsic component of cell outer membrane
intersection_of: GO:0031224 ! intrinsic component of membrane
intersection_of: part_of GO:0031241 ! periplasmic side of cell outer membrane
relationship: part_of GO:0031241 ! periplasmic side of cell outer membrane

[Term]
id: GO:0031247
name: actin rod assembly
namespace: biological_process
def: "The assembly of actin rods, a cellular structure consisting of parallel, hexagonally arranged actin tubules." [GOC:pg, PMID:14706699]
synonym: "actin rod formation" RELATED [GOC:mah]
is_a: GO:0051017 ! actin filament bundle assembly

[Term]
id: GO:0031248
name: protein acetyltransferase complex
namespace: cellular_component
def: "A complex that catalyzes the transfer of an acetyl group to a protein acceptor molecule." [GOC:bf]
subset: goslim_pir
is_a: GO:0044424 ! intracellular part
is_a: GO:1902493 ! acetyltransferase complex

[Term]
id: GO:0031249
name: denatured protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with denatured proteins." [GOC:mlg]
comment: Note that this term should not be confused with 'unfolded protein binding ; GO:0051082', which usually refers to proteins that have not yet folded into their active states. Denatured proteins once were in their correct functional conformations, but have become incorrectly folded, and often form aggregates.
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0031250
name: anaerobic ribonucleoside-triphosphate reductase complex
namespace: cellular_component
def: "An enzyme complex composed of 4 subunits, 2 copies of the large protein (nrdD in E. coli) and 2 copies of the small protein (nrdG in E. coli). It catalyzes the generation of 2'deoxyribonucleotides under anaerobic growth conditions. The larger subunit is the catalytic unit that is activated by the smaller iron-binding subunit." [GOC:mlg]
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0031251
name: PAN complex
namespace: cellular_component
def: "A complex that possesses poly(A)-specific ribonuclease activity; catalyzes the message-specific shortening of mRNA poly(A) tails. Contains at least two subunits, known as Pan2p and Pan3p in Saccharomyces." [PMID:9774670]
synonym: "poly(A) nuclease complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0031252
name: cell leading edge
namespace: cellular_component
def: "The area of a motile cell closest to the direction of movement." [GOC:pg]
subset: goslim_pir
synonym: "front of cell" EXACT []
synonym: "leading edge of cell" EXACT []
is_a: GO:0044464 ! cell part

[Term]
id: GO:0031253
name: cell projection membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a cell surface projection." [GOC:mah]
synonym: "membrane extension" RELATED []
synonym: "membrane projection" RELATED []
is_a: GO:0044463 ! cell projection part
is_a: GO:0098590 ! plasma membrane region
relationship: part_of GO:0005886 ! plasma membrane

[Term]
id: GO:0031254
name: cell trailing edge
namespace: cellular_component
def: "The area of a motile cell opposite to the direction of movement." [GOC:pg]
subset: goslim_pir
synonym: "back of cell" EXACT []
synonym: "trailing edge" EXACT []
is_a: GO:0044464 ! cell part

[Term]
id: GO:0031255
name: lateral part of motile cell
namespace: cellular_component
def: "The area of a motile cell perpendicular to the direction of movement." [GOC:pg, GOC:pr]
is_a: GO:0097574 ! lateral part of cell

[Term]
id: GO:0031256
name: leading edge membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding the leading edge of a motile cell." [GOC:mah]
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0031252 ! cell leading edge

[Term]
id: GO:0031257
name: cell trailing edge membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding the trailing edge of a motile cell." [GOC:mah]
synonym: "trailing edge membrane" EXACT []
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0031254 ! cell trailing edge

[Term]
id: GO:0031258
name: lamellipodium membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a lamellipodium." [GOC:mah]
is_a: GO:0031253 ! cell projection membrane
is_a: GO:0031256 ! leading edge membrane
relationship: part_of GO:0030027 ! lamellipodium

[Term]
id: GO:0031259
name: uropod membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a uropod." [GOC:mah]
synonym: "uropodium membrane" EXACT []
is_a: GO:0031253 ! cell projection membrane
is_a: GO:0031257 ! cell trailing edge membrane
relationship: part_of GO:0001931 ! uropod

[Term]
id: GO:0031260
name: pseudopodium membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a pseudopodium." [GOC:mah]
is_a: GO:0031253 ! cell projection membrane
relationship: part_of GO:0031143 ! pseudopodium

[Term]
id: GO:0031261
name: DNA replication preinitiation complex
namespace: cellular_component
def: "A protein-DNA complex assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication. The preinitiation complex is formed by the assembly of additional proteins onto an existing prereplicative complex. In budding yeast, the additional proteins include Cdc45p, Sld2p, Sld3p, Dpb11p, DNA polymerases, and others; in fission yeast the GINS complex is present." [GOC:bf, GOC:hjd, GOC:jl, GOC:pr, GOC:rb, GOC:vw, PMID:12694535, PMID:15194812]
synonym: "pre-IC" EXACT []
is_a: GO:0032993 ! protein-DNA complex
is_a: GO:0044451 ! nucleoplasm part
relationship: has_part GO:0005656 ! nuclear pre-replicative complex

[Term]
id: GO:0031262
name: Ndc80 complex
namespace: cellular_component
def: "A protein complex conserved among eukaryotes that forms part of the kinetochore and plays an essential role in forming stable kinetochore-microtubule attachments. The complex contains proteins known in several species, including budding and fission yeasts, as Ndc80p, Nuf2p, Spc24p, and Spc25p. In vertebrates it is part of the outer plate of the kinetochore." [PMID:15509863, PMID:15661517]
synonym: "Nuf2-Ndc80 complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000776 ! kinetochore

[Term]
id: GO:0031263
name: amine-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O + amine(out) = ADP + phosphate + amine(in)." [GOC:mlg]
subset: gosubset_prok
synonym: "amine ABC transporter" NARROW []
is_a: GO:0005275 ! amine transmembrane transporter activity
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances

[Term]
id: GO:0031264
name: death-inducing signaling complex
namespace: cellular_component
def: "A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor, and may control the activation of caspases 8 and 10." [GOC:mtg_apoptosis, PMID:12628743, PMID:12655293, PMID:8521815]
comment: Gene products that may be annotated to this term include: 1) ligand-bound receptors such as FAS/CD95 (though care should be taken because FAS can also act as a non-apoptotic signal transducer); 2) signaling molecules such as FADD (FAS-associated protein with a death domain), cIAPs (cellular inhibitor of apoptosis proteins), c-FLIPs and caspases 8 and 10.
subset: goslim_pir
synonym: "death receptor-induced signaling complex" EXACT []
synonym: "death receptor-induced signalling complex" EXACT []
synonym: "death-inducing signalling complex" EXACT []
synonym: "DISC" EXACT []
synonym: "DISC protein complex" EXACT []
xref: Wikipedia:Death-inducing_signaling_complex
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0031265
name: CD95 death-inducing signaling complex
namespace: cellular_component
def: "A protein complex formed upon binding of Fas/CD95/APO-1 to its ligand. The complex includes FADD/Mort1, procaspase-8/10 and c-FLIP in addition to the ligand-bound receptor." [PMID:12628743, PMID:12655293]
synonym: "CD95 death-inducing signalling complex" EXACT []
synonym: "CD95 DISC" EXACT []
synonym: "Fas death-inducing signaling complex" EXACT []
is_a: GO:0031264 ! death-inducing signaling complex

[Term]
id: GO:0031266
name: TRAIL death-inducing signaling complex
namespace: cellular_component
def: "A protein complex formed upon binding of TRAIL to its ligand. The complex includes FADD/Mort1 and procaspase-8 addition to the ligand-bound receptor." [PMID:12628743, PMID:12655293]
synonym: "TRAIL death-inducing signalling complex" EXACT []
synonym: "TRAIL DISC" EXACT []
is_a: GO:0031264 ! death-inducing signaling complex

[Term]
id: GO:0031267
name: small GTPase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a small monomeric GTPase." [GOC:mah]
is_a: GO:0051020 ! GTPase binding

[Term]
id: GO:0031268
name: pseudopodium organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pseudopodium, a temporary protrusion or retractile process of a cell, associated with cellular movement." [GOC:pg]
synonym: "pseudopodium organisation" EXACT [GOC:curators]
synonym: "pseudopodium organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0030030 ! cell projection organization

[Term]
id: GO:0031269
name: pseudopodium assembly
namespace: biological_process
def: "The assembly of a pseudopodium by rearrangement of the actin cytoskeleton and overlying membrane." [GOC:dph, GOC:mah, GOC:pg, GOC:tb]
synonym: "pseudopodium extension" EXACT []
synonym: "pseudopodium formation" RELATED [GOC:dph, GOC:tb]
is_a: GO:0030031 ! cell projection assembly
is_a: GO:0031268 ! pseudopodium organization

[Term]
id: GO:0031270
name: pseudopodium retraction
namespace: biological_process
def: "The myosin-based contraction and retraction of the pseudopodium." [GOC:pg]
is_a: GO:0031268 ! pseudopodium organization

[Term]
id: GO:0031271
name: lateral pseudopodium assembly
namespace: biological_process
def: "The extension of a pseudopodium from the lateral area of a cell." [GOC:dph, GOC:mah, GOC:pg, GOC:tb]
synonym: "lateral pseudopodium formation" RELATED [GOC:dph, GOC:tb]
is_a: GO:0031269 ! pseudopodium assembly

[Term]
id: GO:0031272
name: regulation of pseudopodium assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the assembly of pseudopodia." [GOC:pg]
synonym: "regulation of pseudopodium formation" RELATED []
is_a: GO:0060491 ! regulation of cell projection assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031269 ! pseudopodium assembly
relationship: regulates GO:0031269 ! pseudopodium assembly

[Term]
id: GO:0031273
name: negative regulation of pseudopodium assembly
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of pseudopodia." [GOC:pg]
synonym: "down regulation of pseudopodium formation" RELATED []
synonym: "down-regulation of pseudopodium formation" RELATED []
synonym: "downregulation of pseudopodium formation" RELATED []
synonym: "inhibition of pseudopodium formation" NARROW []
synonym: "negative regulation of pseudopodium formation" RELATED []
is_a: GO:0031272 ! regulation of pseudopodium assembly
is_a: GO:0031345 ! negative regulation of cell projection organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0031269 ! pseudopodium assembly
relationship: negatively_regulates GO:0031269 ! pseudopodium assembly

[Term]
id: GO:0031274
name: positive regulation of pseudopodium assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the assembly of pseudopodia." [GOC:pg]
synonym: "activation of pseudopodium formation" NARROW []
synonym: "positive regulation of pseudopodium formation" RELATED [GOC:dph]
synonym: "stimulation of pseudopodium formation" NARROW []
synonym: "up regulation of pseudopodium formation" RELATED []
synonym: "up-regulation of pseudopodium formation" RELATED []
synonym: "upregulation of pseudopodium formation" RELATED []
is_a: GO:0031272 ! regulation of pseudopodium assembly
is_a: GO:0031346 ! positive regulation of cell projection organization
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0031269 ! pseudopodium assembly
relationship: positively_regulates GO:0031269 ! pseudopodium assembly

[Term]
id: GO:0031275
name: regulation of lateral pseudopodium assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the assembly of pseudopodia from the lateral side of the cell." [GOC:dph, GOC:pg, GOC:tb]
synonym: "regulation of lateral pseudopodium formation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0031272 ! regulation of pseudopodium assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031271 ! lateral pseudopodium assembly
relationship: regulates GO:0031271 ! lateral pseudopodium assembly

[Term]
id: GO:0031276
name: negative regulation of lateral pseudopodium assembly
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of pseudopodia from the lateral side of the cell." [GOC:dph, GOC:pg, GOC:tb]
synonym: "down regulation of lateral pseudopodium formation" RELATED []
synonym: "down-regulation of lateral pseudopodium formation" RELATED []
synonym: "downregulation of lateral pseudopodium formation" RELATED []
synonym: "inhibition of lateral pseudopodium formation" NARROW []
synonym: "negative regulation of lateral pseudopodium formation" RELATED [GOC:dph]
is_a: GO:0031273 ! negative regulation of pseudopodium assembly
is_a: GO:0031275 ! regulation of lateral pseudopodium assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0031271 ! lateral pseudopodium assembly
relationship: negatively_regulates GO:0031271 ! lateral pseudopodium assembly

[Term]
id: GO:0031277
name: positive regulation of lateral pseudopodium assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the assembly of pseudopodia from the lateral side of the cell." [GOC:dph, GOC:pg, GOC:tb]
synonym: "activation of lateral pseudopodium formation" NARROW []
synonym: "positive regulation of lateral pseudopodium formation" RELATED []
synonym: "stimulation of lateral pseudopodium formation" NARROW []
synonym: "up regulation of lateral pseudopodium formation" RELATED []
synonym: "up-regulation of lateral pseudopodium formation" RELATED []
synonym: "upregulation of lateral pseudopodium formation" RELATED []
is_a: GO:0031274 ! positive regulation of pseudopodium assembly
is_a: GO:0031275 ! regulation of lateral pseudopodium assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0031271 ! lateral pseudopodium assembly
relationship: positively_regulates GO:0031271 ! lateral pseudopodium assembly

[Term]
id: GO:0031278
name: alpha-1,2-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a galactose residue from a donor molecule, such as GDP-galactose or UDP-galactose, to an oligosaccharide, forming an alpha-1,2-linkage." [PMID:7522655]
xref: EC:2.4.1.-
is_a: GO:0008378 ! galactosyltransferase activity

[Term]
id: GO:0031279
name: regulation of cyclase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cyclase activity." [GOC:mah]
subset: gosubset_prok
is_a: GO:0050790 ! regulation of catalytic activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009975 ! cyclase activity
relationship: regulates GO:0009975 ! cyclase activity

[Term]
id: GO:0031280
name: negative regulation of cyclase activity
namespace: biological_process
def: "Any process that stops or reduces the activity of a cyclase." [GOC:mah]
synonym: "down regulation of cyclase activity" EXACT []
synonym: "down-regulation of cyclase activity" EXACT []
synonym: "downregulation of cyclase activity" EXACT []
synonym: "inhibition of cyclase activity" NARROW []
is_a: GO:0031279 ! regulation of cyclase activity
is_a: GO:0043086 ! negative regulation of catalytic activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009975 ! cyclase activity
relationship: negatively_regulates GO:0009975 ! cyclase activity

[Term]
id: GO:0031281
name: positive regulation of cyclase activity
namespace: biological_process
def: "Any process that activates or increases the activity of a cyclase." [GOC:mah]
synonym: "activation of cyclase activity" NARROW []
synonym: "stimulation of cyclase activity" NARROW []
synonym: "up regulation of cyclase activity" EXACT []
synonym: "up-regulation of cyclase activity" EXACT []
synonym: "upregulation of cyclase activity" EXACT []
is_a: GO:0031279 ! regulation of cyclase activity
is_a: GO:0043085 ! positive regulation of catalytic activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009975 ! cyclase activity
relationship: positively_regulates GO:0009975 ! cyclase activity

[Term]
id: GO:0031282
name: regulation of guanylate cyclase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of guanylate cyclase activity." [GOC:mah]
is_a: GO:0030826 ! regulation of cGMP biosynthetic process
is_a: GO:0031279 ! regulation of cyclase activity
is_a: GO:0051339 ! regulation of lyase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004383 ! guanylate cyclase activity
relationship: regulates GO:0004383 ! guanylate cyclase activity

[Term]
id: GO:0031283
name: negative regulation of guanylate cyclase activity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of guanylate cyclase activity." [GOC:mah]
synonym: "down regulation of guanylate cyclase activity" EXACT []
synonym: "down-regulation of guanylate cyclase activity" EXACT []
synonym: "downregulation of guanylate cyclase activity" EXACT []
synonym: "inhibition of guanylate cyclase activity" NARROW []
is_a: GO:0030827 ! negative regulation of cGMP biosynthetic process
is_a: GO:0031280 ! negative regulation of cyclase activity
is_a: GO:0031282 ! regulation of guanylate cyclase activity
is_a: GO:0051350 ! negative regulation of lyase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004383 ! guanylate cyclase activity
relationship: negatively_regulates GO:0004383 ! guanylate cyclase activity

[Term]
id: GO:0031284
name: positive regulation of guanylate cyclase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of guanylate cyclase activity." [GOC:mah]
synonym: "activation of guanylate cyclase activity" NARROW []
synonym: "stimulation of guanylate cyclase activity" NARROW []
synonym: "up regulation of guanylate cyclase activity" EXACT []
synonym: "up-regulation of guanylate cyclase activity" EXACT []
synonym: "upregulation of guanylate cyclase activity" EXACT []
is_a: GO:0030828 ! positive regulation of cGMP biosynthetic process
is_a: GO:0031281 ! positive regulation of cyclase activity
is_a: GO:0031282 ! regulation of guanylate cyclase activity
is_a: GO:0051349 ! positive regulation of lyase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004383 ! guanylate cyclase activity
relationship: positively_regulates GO:0004383 ! guanylate cyclase activity

[Term]
id: GO:0031285
name: regulation of sorocarp stalk cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sorocarp stalk cell differentiation. An example of this process is found in Dictyostelium discoideum." [dictyBase_REF:5048, GOC:kp, GOC:mtg_sensu]
synonym: "regulation of stalk cell differentiation" EXACT []
is_a: GO:0030856 ! regulation of epithelial cell differentiation
is_a: GO:0031156 ! regulation of sorocarp development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031149 ! sorocarp stalk cell differentiation
relationship: regulates GO:0031149 ! sorocarp stalk cell differentiation

[Term]
id: GO:0031286
name: negative regulation of sorocarp stalk cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sorocarp stalk cell differentiation. An example of this process is found in Dictyostelium discoideum." [dictyBase_REF:5048, GOC:kp, GOC:mtg_sensu]
synonym: "down regulation of stalk cell differentiation" EXACT []
synonym: "down-regulation of stalk cell differentiation" EXACT []
synonym: "downregulation of stalk cell differentiation" EXACT []
synonym: "inhibition of stalk cell differentiation" NARROW []
synonym: "negative regulation of stalk cell differentiation" EXACT []
is_a: GO:0010648 ! negative regulation of cell communication
is_a: GO:0030857 ! negative regulation of epithelial cell differentiation
is_a: GO:0031285 ! regulation of sorocarp stalk cell differentiation
is_a: GO:0032108 ! negative regulation of response to nutrient levels
is_a: GO:0075262 ! negative regulation of spore-bearing organ development
is_a: GO:1903665 ! negative regulation of asexual reproduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0031149 ! sorocarp stalk cell differentiation
relationship: negatively_regulates GO:0031149 ! sorocarp stalk cell differentiation

[Term]
id: GO:0031287
name: positive regulation of sorocarp stalk cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sorocarp stalk cell differentiation. An example of this process is found in Dictyostelium discoideum." [dictyBase_REF:5048, GOC:kp, GOC:mtg_sensu]
synonym: "activation of stalk cell differentiation" NARROW []
synonym: "positive regulation of stalk cell differentiation" EXACT []
synonym: "stimulation of stalk cell differentiation" NARROW []
synonym: "up regulation of stalk cell differentiation" EXACT []
synonym: "up-regulation of stalk cell differentiation" EXACT []
synonym: "upregulation of stalk cell differentiation" EXACT []
is_a: GO:0010647 ! positive regulation of cell communication
is_a: GO:0030858 ! positive regulation of epithelial cell differentiation
is_a: GO:0031285 ! regulation of sorocarp stalk cell differentiation
is_a: GO:0032109 ! positive regulation of response to nutrient levels
is_a: GO:0075261 ! positive regulation of spore-bearing organ development
is_a: GO:1903666 ! positive regulation of asexual reproduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0031149 ! sorocarp stalk cell differentiation
relationship: positively_regulates GO:0031149 ! sorocarp stalk cell differentiation

[Term]
id: GO:0031288
name: sorocarp morphogenesis
namespace: biological_process
def: "The process in which the sorocarp is generated and organized. An example of this process is found in Dictyostelium discoideum." [dictyBase_REF:5048, GOC:kp, GOC:mtg_sensu]
synonym: "fruiting body morphogenesis" BROAD [DDANAT:0000012]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0030587 ! sorocarp development

[Term]
id: GO:0031289
name: actin phosphorylation
namespace: biological_process
def: "The transfer of one or more phosphate groups to an actin molecule." [GOC:mah]
is_a: GO:0006468 ! protein phosphorylation
is_a: GO:0030047 ! actin modification

[Term]
id: GO:0031290
name: retinal ganglion cell axon guidance
namespace: biological_process
def: "The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:ejs]
synonym: "retinal ganglion cell axon pathfinding" EXACT []
is_a: GO:0007411 ! axon guidance

[Term]
id: GO:0031291
name: Ran protein signal transduction
namespace: biological_process
def: "A series of molecular signals within the cell that are mediated by a member of the Ran family of proteins switching to a GTP-bound active state." [GOC:mah]
is_a: GO:0007265 ! Ras protein signal transduction

[Term]
id: GO:0031292
name: gene conversion at mating-type locus, DNA double-strand break processing
namespace: biological_process
def: "The 5' to 3' exonucleolytic resection of the DNA at the site of the break at the mating-type locus to form a 3' single-strand DNA overhang." [GOC:mah]
is_a: GO:0000729 ! DNA double-strand break processing
is_a: GO:0022414 ! reproductive process
intersection_of: GO:0000729 ! DNA double-strand break processing
intersection_of: part_of GO:0007534 ! gene conversion at mating-type locus
relationship: part_of GO:0007534 ! gene conversion at mating-type locus

[Term]
id: GO:0031293
name: membrane protein intracellular domain proteolysis
namespace: biological_process
def: "The proteolytic cleavage of a transmembrane protein leading to the release of an intracellular domain." [PMID:12808018]
synonym: "membrane protein solubilization" RELATED []
xref: Reactome:REACT_107905 "Regulated proteolysis of p75NTR, Sus scrofa"
xref: Reactome:REACT_13443 "Regulated proteolysis of p75NTR, Homo sapiens"
xref: Reactome:REACT_77915 "Regulated proteolysis of p75NTR, Gallus gallus"
xref: Reactome:REACT_79297 "Regulated proteolysis of p75NTR, Bos taurus"
xref: Reactome:REACT_79586 "Regulated proteolysis of p75NTR, Canis familiaris"
xref: Reactome:REACT_85437 "Regulated proteolysis of p75NTR, Mus musculus"
xref: Reactome:REACT_90773 "Regulated proteolysis of p75NTR, Xenopus tropicalis"
xref: Reactome:REACT_91039 "Regulated proteolysis of p75NTR, Danio rerio"
xref: Reactome:REACT_94866 "Regulated proteolysis of p75NTR, Rattus norvegicus"
is_a: GO:0033619 ! membrane protein proteolysis

[Term]
id: GO:0031294
name: lymphocyte costimulation
namespace: biological_process
def: "The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B- or T cell receptor to augment B- or T cell activation." [ISBN:0781735149]
synonym: "lymphocyte co-stimulation" EXACT []
is_a: GO:0002376 ! immune system process
is_a: GO:0051251 ! positive regulation of lymphocyte activation

[Term]
id: GO:0031295
name: T cell costimulation
namespace: biological_process
def: "The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation." [ISBN:0781735149]
synonym: "T cell co-stimulation" EXACT []
synonym: "T lymphocyte costimulation" EXACT []
synonym: "T-cell co-stimulation" EXACT []
synonym: "T-cell costimulation" EXACT []
synonym: "T-lymphocyte costimulation" EXACT []
xref: Reactome:REACT_100170 "Costimulation by the CD28 family, Schizosaccharomyces pombe"
xref: Reactome:REACT_101463 "CD28 co-stimulation, Canis familiaris"
xref: Reactome:REACT_102117 "CD28 co-stimulation, Mus musculus"
xref: Reactome:REACT_103961 "CD28 co-stimulation, Taeniopygia guttata"
xref: Reactome:REACT_106623 "Costimulation by the CD28 family, Taeniopygia guttata"
xref: Reactome:REACT_19183 "CD28 co-stimulation, Homo sapiens"
xref: Reactome:REACT_19344 "Costimulation by the CD28 family, Homo sapiens"
xref: Reactome:REACT_29252 "Costimulation by the CD28 family, Sus scrofa"
xref: Reactome:REACT_30546 "CD28 co-stimulation, Drosophila melanogaster"
xref: Reactome:REACT_31384 "CD28 co-stimulation, Rattus norvegicus"
xref: Reactome:REACT_32726 "CD28 co-stimulation, Xenopus tropicalis"
xref: Reactome:REACT_34507 "CD28 co-stimulation, Schizosaccharomyces pombe"
xref: Reactome:REACT_34799 "Costimulation by the CD28 family, Drosophila melanogaster"
xref: Reactome:REACT_80100 "Costimulation by the CD28 family, Xenopus tropicalis"
xref: Reactome:REACT_80962 "CD28 co-stimulation, Gallus gallus"
xref: Reactome:REACT_82219 "Costimulation by the CD28 family, Saccharomyces cerevisiae"
xref: Reactome:REACT_83737 "Costimulation by the CD28 family, Danio rerio"
xref: Reactome:REACT_85960 "CD28 co-stimulation, Sus scrofa"
xref: Reactome:REACT_87011 "Costimulation by the CD28 family, Rattus norvegicus"
xref: Reactome:REACT_88230 "CD28 co-stimulation, Saccharomyces cerevisiae"
xref: Reactome:REACT_90053 "Costimulation by the CD28 family, Caenorhabditis elegans"
xref: Reactome:REACT_92260 "Costimulation by the CD28 family, Mus musculus"
xref: Reactome:REACT_92657 "Costimulation by the CD28 family, Bos taurus"
xref: Reactome:REACT_93210 "CD28 co-stimulation, Danio rerio"
xref: Reactome:REACT_93829 "Costimulation by the CD28 family, Gallus gallus"
xref: Reactome:REACT_96706 "CD28 co-stimulation, Caenorhabditis elegans"
xref: Reactome:REACT_97654 "Costimulation by the CD28 family, Canis familiaris"
xref: Reactome:REACT_98418 "CD28 co-stimulation, Bos taurus"
is_a: GO:0031294 ! lymphocyte costimulation
is_a: GO:0050870 ! positive regulation of T cell activation

[Term]
id: GO:0031296
name: B cell costimulation
namespace: biological_process
def: "The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B cell receptor to augment B cell activation." [ISBN:0781735149]
synonym: "B cell co-stimulation" EXACT []
synonym: "B lymphocyte co-stimulation" EXACT []
synonym: "B lymphocyte costimulation" EXACT []
synonym: "B-cell co-stimulation" EXACT []
synonym: "B-cell costimulation" EXACT []
synonym: "B-lymphocyte co-stimulation" EXACT []
synonym: "B-lymphocyte costimulation" EXACT []
is_a: GO:0031294 ! lymphocyte costimulation
is_a: GO:0050871 ! positive regulation of B cell activation

[Term]
id: GO:0031297
name: replication fork processing
namespace: biological_process
def: "The process in which a DNA replication fork that has stalled (due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes) is repaired and replication is restarted." [PMID:11459955, PMID:15367656, PMID:17660542]
synonym: "collapsed replication fork processing" EXACT []
synonym: "recovery from replication fork arrest" EXACT []
synonym: "recovery from replication fork stalling" EXACT []
synonym: "replication fork restart" RELATED [PMID:20842177]
synonym: "replication restart" RELATED [GOC:bhm, PMID:15780929]
is_a: GO:0006974 ! cellular response to DNA damage stimulus
is_a: GO:0044710 ! single-organism metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0045005 ! DNA-dependent DNA replication maintenance of fidelity

[Term]
id: GO:0031298
name: replication fork protection complex
namespace: cellular_component
def: "A protein complex conserved in eukaryotes and associated with the replication fork; the complex stabilizes stalled replication forks and is thought to be involved in coordinating leading- and lagging-strand synthesis and in replication checkpoint signaling." [PMID:15367656]
synonym: "replisome progression complex" EXACT [GOC:vw]
synonym: "Swi1-Swi3 complex" NARROW []
synonym: "TIMELESS-TIPIN complex" NARROW [GOC:mah, GOC:vw]
is_a: GO:0043234 ! protein complex
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0043596 ! nuclear replication fork

[Term]
id: GO:0031299
name: taurine-pyruvate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyruvate + taurine = L-alanine + sulfoacetaldehyde." [EC:2.6.1.77, RHEA:10423]
synonym: "taurine:pyruvate aminotransferase activity" EXACT [EC:2.6.1.77]
synonym: "Tpa" RELATED [EC:2.6.1.77]
xref: EC:2.6.1.77
xref: KEGG:R05652
xref: MetaCyc:TAURINE-AMINOTRANSFERASE-RXN
xref: RHEA:10423
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0031300
name: intrinsic component of organelle membrane
namespace: cellular_component
def: "The component of the organelle membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
synonym: "intrinsic to organelle membrane" NARROW []
is_a: GO:0031224 ! intrinsic component of membrane
is_a: GO:0044422 ! organelle part
intersection_of: GO:0031224 ! intrinsic component of membrane
intersection_of: part_of GO:0031090 ! organelle membrane
relationship: part_of GO:0031090 ! organelle membrane

[Term]
id: GO:0031301
name: integral component of organelle membrane
namespace: cellular_component
def: "The component of the organelle membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]
synonym: "integral to organelle membrane" EXACT []
is_a: GO:0016021 ! integral component of membrane
is_a: GO:0031300 ! intrinsic component of organelle membrane
intersection_of: GO:0016021 ! integral component of membrane
intersection_of: part_of GO:0031090 ! organelle membrane
relationship: part_of GO:0031090 ! organelle membrane

[Term]
id: GO:0031302
name: intrinsic component of endosome membrane
namespace: cellular_component
def: "The component of the endosome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
synonym: "intrinsic to endosome membrane" NARROW []
is_a: GO:0031310 ! intrinsic component of vacuolar membrane
is_a: GO:0044440 ! endosomal part
intersection_of: GO:0031224 ! intrinsic component of membrane
intersection_of: part_of GO:0010008 ! endosome membrane
relationship: part_of GO:0010008 ! endosome membrane

[Term]
id: GO:0031303
name: integral component of endosome membrane
namespace: cellular_component
def: "The component of the endosome membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]
synonym: "integral to endosome membrane" NARROW []
is_a: GO:0031166 ! integral component of vacuolar membrane
is_a: GO:0031302 ! intrinsic component of endosome membrane
intersection_of: GO:0016021 ! integral component of membrane
intersection_of: part_of GO:0010008 ! endosome membrane
relationship: part_of GO:0010008 ! endosome membrane

[Term]
id: GO:0031304
name: intrinsic component of mitochondrial inner membrane
namespace: cellular_component
def: "The component of the mitochondrial inner membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
synonym: "intrinsic to mitochondrial inner membrane" NARROW []
is_a: GO:0098573 ! intrinsic component of mitochondrial membrane
intersection_of: GO:0031224 ! intrinsic component of membrane
intersection_of: part_of GO:0005743 ! mitochondrial inner membrane
relationship: part_of GO:0005743 ! mitochondrial inner membrane

[Term]
id: GO:0031305
name: integral component of mitochondrial inner membrane
namespace: cellular_component
def: "The component of the mitochondrial inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]
synonym: "integral to mitochondrial inner membrane" EXACT []
is_a: GO:0031304 ! intrinsic component of mitochondrial inner membrane
is_a: GO:0032592 ! integral component of mitochondrial membrane
intersection_of: GO:0016021 ! integral component of membrane
intersection_of: part_of GO:0005743 ! mitochondrial inner membrane
relationship: part_of GO:0005743 ! mitochondrial inner membrane

[Term]
id: GO:0031306
name: intrinsic component of mitochondrial outer membrane
namespace: cellular_component
def: "The component of the mitochondrial outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
synonym: "intrinsic to mitochondrial outer membrane" NARROW []
is_a: GO:0098573 ! intrinsic component of mitochondrial membrane
intersection_of: GO:0031224 ! intrinsic component of membrane
intersection_of: part_of GO:0005741 ! mitochondrial outer membrane
relationship: part_of GO:0005741 ! mitochondrial outer membrane

[Term]
id: GO:0031307
name: integral component of mitochondrial outer membrane
namespace: cellular_component
def: "The component of the mitochondrial outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]
synonym: "integral to mitochondrial outer membrane" NARROW []
is_a: GO:0031306 ! intrinsic component of mitochondrial outer membrane
is_a: GO:0032592 ! integral component of mitochondrial membrane
intersection_of: GO:0032592 ! integral component of mitochondrial membrane
intersection_of: part_of GO:0005741 ! mitochondrial outer membrane
relationship: part_of GO:0005741 ! mitochondrial outer membrane

[Term]
id: GO:0031308
name: intrinsic component of nuclear outer membrane
namespace: cellular_component
def: "The component of the nuclear outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
synonym: "intrinsic to nuclear outer membrane" NARROW []
is_a: GO:0031300 ! intrinsic component of organelle membrane
is_a: GO:0044453 ! nuclear membrane part
intersection_of: GO:0031224 ! intrinsic component of membrane
intersection_of: part_of GO:0005640 ! nuclear outer membrane
relationship: part_of GO:0005640 ! nuclear outer membrane

[Term]
id: GO:0031309
name: integral component of nuclear outer membrane
namespace: cellular_component
def: "The component of the nuclear outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]
synonym: "integral to nuclear outer membrane" NARROW []
is_a: GO:0031301 ! integral component of organelle membrane
is_a: GO:0031308 ! intrinsic component of nuclear outer membrane
intersection_of: GO:0016021 ! integral component of membrane
intersection_of: part_of GO:0005640 ! nuclear outer membrane
relationship: part_of GO:0005640 ! nuclear outer membrane

[Term]
id: GO:0031310
name: intrinsic component of vacuolar membrane
namespace: cellular_component
def: "The component of the vacuolar membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
synonym: "intrinsic to vacuolar membrane" NARROW []
is_a: GO:0031300 ! intrinsic component of organelle membrane
is_a: GO:0044437 ! vacuolar part
intersection_of: GO:0031224 ! intrinsic component of membrane
intersection_of: part_of GO:0005774 ! vacuolar membrane
relationship: part_of GO:0005774 ! vacuolar membrane

[Term]
id: GO:0031311
name: intrinsic component of contractile vacuolar membrane
namespace: cellular_component
def: "The component of the contractile vacuolar membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
synonym: "intrinsic to contractile vacuolar membrane" NARROW []
is_a: GO:0031310 ! intrinsic component of vacuolar membrane
is_a: GO:0044433 ! cytoplasmic vesicle part
intersection_of: GO:0031224 ! intrinsic component of membrane
intersection_of: part_of GO:0031164 ! contractile vacuolar membrane
relationship: part_of GO:0031164 ! contractile vacuolar membrane

[Term]
id: GO:0031312
name: extrinsic component of organelle membrane
namespace: cellular_component
def: "The component of an organelle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah]
synonym: "extrinsic to organelle membrane" NARROW []
is_a: GO:0019898 ! extrinsic component of membrane
is_a: GO:0044446 ! intracellular organelle part
intersection_of: GO:0019898 ! extrinsic component of membrane
intersection_of: part_of GO:0031090 ! organelle membrane
relationship: part_of GO:0031090 ! organelle membrane

[Term]
id: GO:0031313
name: extrinsic component of endosome membrane
namespace: cellular_component
def: "The component of an endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah]
synonym: "extrinsic to endosome membrane" NARROW []
is_a: GO:0000306 ! extrinsic component of vacuolar membrane
is_a: GO:0044440 ! endosomal part
intersection_of: GO:0019898 ! extrinsic component of membrane
intersection_of: part_of GO:0010008 ! endosome membrane
relationship: part_of GO:0010008 ! endosome membrane

[Term]
id: GO:0031314
name: extrinsic component of mitochondrial inner membrane
namespace: cellular_component
def: "The component of mitochondrial inner membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah]
synonym: "extrinsic to mitochondrial inner membrane" NARROW []
is_a: GO:0031312 ! extrinsic component of organelle membrane
is_a: GO:0044455 ! mitochondrial membrane part
intersection_of: GO:0019898 ! extrinsic component of membrane
intersection_of: part_of GO:0005743 ! mitochondrial inner membrane
relationship: part_of GO:0005743 ! mitochondrial inner membrane

[Term]
id: GO:0031315
name: extrinsic component of mitochondrial outer membrane
namespace: cellular_component
def: "The component of a mitochondrial outer membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah]
synonym: "extrinsic to mitochondrial outer membrane" NARROW []
is_a: GO:0031312 ! extrinsic component of organelle membrane
is_a: GO:0044455 ! mitochondrial membrane part
intersection_of: GO:0019898 ! extrinsic component of membrane
intersection_of: part_of GO:0005741 ! mitochondrial outer membrane
relationship: part_of GO:0005741 ! mitochondrial outer membrane

[Term]
id: GO:0031316
name: extrinsic component of nuclear outer membrane
namespace: cellular_component
def: "The component of a nuclear outer membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah]
synonym: "extrinsic to nuclear outer membrane" NARROW []
is_a: GO:0031312 ! extrinsic component of organelle membrane
is_a: GO:0044453 ! nuclear membrane part
intersection_of: GO:0019898 ! extrinsic component of membrane
intersection_of: part_of GO:0005640 ! nuclear outer membrane
relationship: part_of GO:0005640 ! nuclear outer membrane

[Term]
id: GO:0031317
name: tripartite ATP-independent periplasmic transporter complex
namespace: cellular_component
def: "A complex consisting of two membrane proteins and one extracytoplasmic solute receptor. Such transporters transport a variety of substrates without direct ATP power, instead using energy from ion gradients." [GOC:mlg]
subset: gosubset_prok
synonym: "TRAP transporter complex" EXACT []
synonym: "TRAP-T transporter complex" EXACT []
is_a: GO:0044464 ! cell part
is_a: GO:1990351 ! transporter complex

[Term]
id: GO:0031318
name: detection of folic acid
namespace: biological_process
def: "The series of events in which a folic acid stimulus is received by a cell and converted into a molecular signal." [GOC:pg]
synonym: "detection of folate" EXACT []
synonym: "folate detection" EXACT []
synonym: "folate sensing" EXACT []
synonym: "folic acid detection" EXACT []
synonym: "folic acid sensing" EXACT []
is_a: GO:0009594 ! detection of nutrient
is_a: GO:0051593 ! response to folic acid

[Term]
id: GO:0031319
name: detection of cAMP
namespace: biological_process
def: "The series of events in which a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus is received by a cell and converted into a molecular signal; cAMP is the nucleotide cyclic AMP." [GOC:pg]
synonym: "3',5'-cAMP detection" EXACT []
synonym: "3',5'-cAMP sensing" EXACT []
synonym: "cAMP detection" EXACT []
synonym: "cAMP sensing" EXACT []
synonym: "cyclic AMP detection" EXACT []
synonym: "detection of 3',5' cAMP" EXACT []
synonym: "detection of 3',5'-cAMP" EXACT []
synonym: "detection of adenosine 3',5'-cyclophosphate" EXACT []
synonym: "detection of cyclic AMP" EXACT []
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0051591 ! response to cAMP

[Term]
id: GO:0031320
name: hexitol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: hexitol + acceptor = hexose + reduced acceptor." [GOC:mah]
subset: gosubset_prok
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0031321
name: ascospore-type prospore assembly
namespace: biological_process
def: "During ascospore formation, the process in which each haploid nucleus becomes encapsulated by a double membrane." [GOC:mah, PMID:14702385]
synonym: "ascospore-type prospore formation" EXACT []
synonym: "forespore formation" RELATED []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0030437 ! ascospore formation

[Term]
id: GO:0031322
name: ascospore-type prospore-specific spindle pole body remodeling
namespace: biological_process
def: "A spindle pole body (SPB) organization process that takes place during the second meiotic division during ascospore formation and results in the structural reorganization of the SPB; includes the recruitment of sporulation-specific proteins to the outer plaque to form the meiotic outer plaque (MOP)." [GOC:mah, PMID:14702385]
synonym: "ascospore-type prospore-specific spindle pole body modification" RELATED [GOC:vw]
synonym: "ascospore-type prospore-specific spindle pole body remodelling" EXACT [GOC:mah]
synonym: "forespore specific spindle pole body remodeling" EXACT []
synonym: "forespore-specific spindle pole body remodeling" EXACT []
synonym: "prospore-specific spindle pole body remodeling" EXACT []
synonym: "sporulation-specific spindle pole body remodeling" EXACT []
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0031321 ! ascospore-type prospore assembly
relationship: part_of GO:1990395 ! meiotic spindle pole body organization

[Term]
id: GO:0031323
name: regulation of cellular metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of cellular metabolism" EXACT []
is_a: GO:0019222 ! regulation of metabolic process
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044237 ! cellular metabolic process
relationship: regulates GO:0044237 ! cellular metabolic process

[Term]
id: GO:0031324
name: negative regulation of cellular metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation of cellular metabolic process" EXACT []
synonym: "down-regulation of cellular metabolic process" EXACT []
synonym: "downregulation of cellular metabolic process" EXACT []
synonym: "inhibition of cellular metabolic process" NARROW []
synonym: "negative regulation of cellular metabolism" EXACT []
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:0048523 ! negative regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044237 ! cellular metabolic process
relationship: negatively_regulates GO:0044237 ! cellular metabolic process

[Term]
id: GO:0031325
name: positive regulation of cellular metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah]
subset: gosubset_prok
synonym: "activation of cellular metabolic process" NARROW []
synonym: "positive regulation of cellular metabolism" EXACT []
synonym: "stimulation of cellular metabolic process" NARROW []
synonym: "up regulation of cellular metabolic process" EXACT []
synonym: "up-regulation of cellular metabolic process" EXACT []
synonym: "upregulation of cellular metabolic process" EXACT []
xref: Reactome:REACT_101225 "ChREBP activates metabolic gene expression, Mus musculus"
xref: Reactome:REACT_102187 "ChREBP activates metabolic gene expression, Escherichia coli"
xref: Reactome:REACT_102331 "ChREBP activates metabolic gene expression, Caenorhabditis elegans"
xref: Reactome:REACT_105293 "ChREBP activates metabolic gene expression, Plasmodium falciparum"
xref: Reactome:REACT_108571 "ChREBP activates metabolic gene expression, Drosophila melanogaster"
xref: Reactome:REACT_109170 "ChREBP activates metabolic gene expression, Xenopus tropicalis"
xref: Reactome:REACT_2122 "ChREBP activates metabolic gene expression, Homo sapiens"
xref: Reactome:REACT_28360 "ChREBP activates metabolic gene expression, Arabidopsis thaliana"
xref: Reactome:REACT_31270 "ChREBP activates metabolic gene expression, Mycobacterium tuberculosis"
xref: Reactome:REACT_79603 "ChREBP activates metabolic gene expression, Canis familiaris"
xref: Reactome:REACT_80902 "ChREBP activates metabolic gene expression, Saccharomyces cerevisiae"
xref: Reactome:REACT_83058 "ChREBP activates metabolic gene expression, Taeniopygia guttata"
xref: Reactome:REACT_84314 "ChREBP activates metabolic gene expression, Oryza sativa"
xref: Reactome:REACT_86633 "ChREBP activates metabolic gene expression, Dictyostelium discoideum"
xref: Reactome:REACT_87840 "ChREBP activates metabolic gene expression, Danio rerio"
xref: Reactome:REACT_88060 "ChREBP activates metabolic gene expression, Rattus norvegicus"
xref: Reactome:REACT_91293 "ChREBP activates metabolic gene expression, Staphylococcus aureus N315"
xref: Reactome:REACT_91429 "ChREBP activates metabolic gene expression, Gallus gallus"
xref: Reactome:REACT_91906 "ChREBP activates metabolic gene expression, Schizosaccharomyces pombe"
xref: Reactome:REACT_92487 "ChREBP activates metabolic gene expression, Bos taurus"
xref: Reactome:REACT_99393 "ChREBP activates metabolic gene expression, Sus scrofa"
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:0048522 ! positive regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044237 ! cellular metabolic process
relationship: positively_regulates GO:0044237 ! cellular metabolic process

[Term]
id: GO:0031326
name: regulation of cellular biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of cellular anabolism" EXACT []
synonym: "regulation of cellular biosynthesis" EXACT []
synonym: "regulation of cellular formation" EXACT []
synonym: "regulation of cellular synthesis" EXACT []
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0031323 ! regulation of cellular metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044249 ! cellular biosynthetic process
relationship: regulates GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0031327
name: negative regulation of cellular biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation of cellular biosynthetic process" EXACT []
synonym: "down-regulation of cellular biosynthetic process" EXACT []
synonym: "downregulation of cellular biosynthetic process" EXACT []
synonym: "inhibition of cellular biosynthetic process" NARROW []
synonym: "negative regulation of cellular anabolism" EXACT []
synonym: "negative regulation of cellular biosynthesis" EXACT []
synonym: "negative regulation of cellular formation" EXACT []
synonym: "negative regulation of cellular synthesis" EXACT []
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044249 ! cellular biosynthetic process
relationship: negatively_regulates GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0031328
name: positive regulation of cellular biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:mah]
subset: gosubset_prok
synonym: "activation of cellular biosynthetic process" NARROW []
synonym: "positive regulation of cellular anabolism" EXACT []
synonym: "positive regulation of cellular biosynthesis" EXACT []
synonym: "positive regulation of cellular formation" EXACT []
synonym: "positive regulation of cellular synthesis" EXACT []
synonym: "stimulation of cellular biosynthetic process" NARROW []
synonym: "up regulation of cellular biosynthetic process" EXACT []
synonym: "up-regulation of cellular biosynthetic process" EXACT []
synonym: "upregulation of cellular biosynthetic process" EXACT []
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044249 ! cellular biosynthetic process
relationship: positively_regulates GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0031329
name: regulation of cellular catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of cellular breakdown" EXACT []
synonym: "regulation of cellular catabolism" EXACT []
synonym: "regulation of cellular degradation" EXACT []
is_a: GO:0009894 ! regulation of catabolic process
is_a: GO:0031323 ! regulation of cellular metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044248 ! cellular catabolic process
relationship: regulates GO:0044248 ! cellular catabolic process

[Term]
id: GO:0031330
name: negative regulation of cellular catabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation of cellular catabolic process" EXACT []
synonym: "down-regulation of cellular catabolic process" EXACT []
synonym: "downregulation of cellular catabolic process" EXACT []
synonym: "inhibition of cellular catabolic process" NARROW []
synonym: "negative regulation of cellular breakdown" EXACT []
synonym: "negative regulation of cellular catabolism" EXACT []
synonym: "negative regulation of cellular degradation" EXACT []
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0031329 ! regulation of cellular catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044248 ! cellular catabolic process
relationship: negatively_regulates GO:0044248 ! cellular catabolic process

[Term]
id: GO:0031331
name: positive regulation of cellular catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:mah]
subset: gosubset_prok
synonym: "activation of cellular catabolic process" NARROW []
synonym: "positive regulation of cellular breakdown" EXACT []
synonym: "positive regulation of cellular catabolism" EXACT []
synonym: "positive regulation of cellular degradation" EXACT []
synonym: "stimulation of cellular catabolic process" NARROW []
synonym: "up regulation of cellular catabolic process" EXACT []
synonym: "up-regulation of cellular catabolic process" EXACT []
synonym: "upregulation of cellular catabolic process" EXACT []
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0031329 ! regulation of cellular catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044248 ! cellular catabolic process
relationship: positively_regulates GO:0044248 ! cellular catabolic process

[Term]
id: GO:0031332
name: RNAi effector complex
namespace: cellular_component
def: "Any protein complex that mediates the effects of small interfering RNAs on gene expression. Most known examples contain one or more members of the Argonaute family of proteins." [GOC:mah, PMID:14704433]
subset: goslim_pir
is_a: GO:0030529 ! intracellular ribonucleoprotein complex

[Term]
id: GO:0031333
name: negative regulation of protein complex assembly
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation of protein complex assembly" EXACT []
synonym: "down-regulation of protein complex assembly" EXACT []
synonym: "downregulation of protein complex assembly" EXACT []
synonym: "inhibition of protein complex assembly" NARROW []
is_a: GO:0043254 ! regulation of protein complex assembly
is_a: GO:0051129 ! negative regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006461 ! protein complex assembly
relationship: negatively_regulates GO:0006461 ! protein complex assembly

[Term]
id: GO:0031334
name: positive regulation of protein complex assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein complex assembly." [GOC:mah]
subset: gosubset_prok
synonym: "activation of protein complex assembly" NARROW []
synonym: "stimulation of protein complex assembly" NARROW []
synonym: "up regulation of protein complex assembly" EXACT []
synonym: "up-regulation of protein complex assembly" EXACT []
synonym: "upregulation of protein complex assembly" EXACT []
is_a: GO:0043254 ! regulation of protein complex assembly
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:0051130 ! positive regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006461 ! protein complex assembly
relationship: positively_regulates GO:0006461 ! protein complex assembly

[Term]
id: GO:0031335
name: regulation of sulfur amino acid metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of sulfur amino acid metabolism" EXACT []
is_a: GO:0006521 ! regulation of cellular amino acid metabolic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000096 ! sulfur amino acid metabolic process
relationship: regulates GO:0000096 ! sulfur amino acid metabolic process

[Term]
id: GO:0031336
name: negative regulation of sulfur amino acid metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation of sulfur amino acid metabolic process" EXACT []
synonym: "down-regulation of sulfur amino acid metabolic process" EXACT []
synonym: "downregulation of sulfur amino acid metabolic process" EXACT []
synonym: "inhibition of sulfur amino acid metabolic process" NARROW []
synonym: "negative regulation of sulfur amino acid metabolism" EXACT []
is_a: GO:0031335 ! regulation of sulfur amino acid metabolic process
is_a: GO:0045763 ! negative regulation of cellular amino acid metabolic process
is_a: GO:0051175 ! negative regulation of sulfur metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000096 ! sulfur amino acid metabolic process
relationship: negatively_regulates GO:0000096 ! sulfur amino acid metabolic process

[Term]
id: GO:0031337
name: positive regulation of sulfur amino acid metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids." [GOC:mah]
subset: gosubset_prok
synonym: "activation of sulfur amino acid metabolic process" NARROW []
synonym: "positive regulation of sulfur amino acid metabolism" EXACT []
synonym: "stimulation of sulfur amino acid metabolic process" NARROW []
synonym: "up regulation of sulfur amino acid metabolic process" EXACT []
synonym: "up-regulation of sulfur amino acid metabolic process" EXACT []
synonym: "upregulation of sulfur amino acid metabolic process" EXACT []
is_a: GO:0031335 ! regulation of sulfur amino acid metabolic process
is_a: GO:0045764 ! positive regulation of cellular amino acid metabolic process
is_a: GO:0051176 ! positive regulation of sulfur metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000096 ! sulfur amino acid metabolic process
relationship: positively_regulates GO:0000096 ! sulfur amino acid metabolic process

[Term]
id: GO:0031338
name: regulation of vesicle fusion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vesicle fusion." [GOC:mah]
is_a: GO:0033043 ! regulation of organelle organization
is_a: GO:0060627 ! regulation of vesicle-mediated transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006906 ! vesicle fusion
relationship: regulates GO:0006906 ! vesicle fusion

[Term]
id: GO:0031339
name: negative regulation of vesicle fusion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of vesicle fusion." [GOC:mah]
synonym: "down regulation of vesicle fusion" EXACT []
synonym: "down-regulation of vesicle fusion" EXACT []
synonym: "downregulation of vesicle fusion" EXACT []
synonym: "inhibition of vesicle fusion" NARROW []
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:0031338 ! regulation of vesicle fusion
is_a: GO:0051051 ! negative regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006906 ! vesicle fusion
relationship: negatively_regulates GO:0006906 ! vesicle fusion

[Term]
id: GO:0031340
name: positive regulation of vesicle fusion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vesicle fusion." [GOC:mah]
synonym: "activation of vesicle fusion" NARROW []
synonym: "stimulation of vesicle fusion" NARROW []
synonym: "up regulation of vesicle fusion" EXACT []
synonym: "up-regulation of vesicle fusion" EXACT []
synonym: "upregulation of vesicle fusion" EXACT []
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:0031338 ! regulation of vesicle fusion
is_a: GO:0051050 ! positive regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006906 ! vesicle fusion
relationship: positively_regulates GO:0006906 ! vesicle fusion

[Term]
id: GO:0031341
name: regulation of cell killing
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell killing, the process in which a cell brings about the death of another cell, either in the same or a different organism." [GOC:mah]
subset: gosubset_prok
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001906 ! cell killing
relationship: regulates GO:0001906 ! cell killing

[Term]
id: GO:0031342
name: negative regulation of cell killing
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell killing." [GOC:mah]
synonym: "down regulation of cell killing" EXACT []
synonym: "down-regulation of cell killing" EXACT []
synonym: "downregulation of cell killing" EXACT []
synonym: "inhibition of cell killing" NARROW []
is_a: GO:0031341 ! regulation of cell killing
is_a: GO:0048519 ! negative regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001906 ! cell killing
relationship: negatively_regulates GO:0001906 ! cell killing

[Term]
id: GO:0031343
name: positive regulation of cell killing
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell killing." [GOC:mah]
synonym: "activation of cell killing" NARROW []
synonym: "stimulation of cell killing" NARROW []
synonym: "up regulation of cell killing" EXACT []
synonym: "up-regulation of cell killing" EXACT []
synonym: "upregulation of cell killing" EXACT []
is_a: GO:0031341 ! regulation of cell killing
is_a: GO:0048518 ! positive regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001906 ! cell killing
relationship: positively_regulates GO:0001906 ! cell killing

[Term]
id: GO:0031344
name: regulation of cell projection organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of cell projection organisation" EXACT [GOC:curators]
synonym: "regulation of cell projection organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030030 ! cell projection organization
relationship: regulates GO:0030030 ! cell projection organization

[Term]
id: GO:0031345
name: negative regulation of cell projection organization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah]
synonym: "down regulation of cell projection organization" EXACT [GOC:mah]
synonym: "down-regulation of cell projection organization" EXACT []
synonym: "downregulation of cell projection organization" EXACT []
synonym: "inhibition of cell projection organization" NARROW []
synonym: "negative regulation of cell projection organisation" EXACT [GOC:curators]
synonym: "negative regulation of cell projection organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0031344 ! regulation of cell projection organization
is_a: GO:0051129 ! negative regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030030 ! cell projection organization
relationship: negatively_regulates GO:0030030 ! cell projection organization

[Term]
id: GO:0031346
name: positive regulation of cell projection organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah]
synonym: "activation of cell projection organization" NARROW []
synonym: "positive regulation of cell projection organisation" EXACT [GOC:curators]
synonym: "positive regulation of cell projection organization and biogenesis" RELATED [GOC:mah]
synonym: "stimulation of cell projection organization" NARROW []
synonym: "up regulation of cell projection organization" EXACT []
synonym: "up-regulation of cell projection organization" EXACT []
synonym: "upregulation of cell projection organization" EXACT []
is_a: GO:0031344 ! regulation of cell projection organization
is_a: GO:0051130 ! positive regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030030 ! cell projection organization
relationship: positively_regulates GO:0030030 ! cell projection organization

[Term]
id: GO:0031347
name: regulation of defense response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a defense response." [GOC:mah]
is_a: GO:0080134 ! regulation of response to stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006952 ! defense response
relationship: regulates GO:0006952 ! defense response

[Term]
id: GO:0031348
name: negative regulation of defense response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a defense response." [GOC:mah]
synonym: "down regulation of defense response" EXACT []
synonym: "down-regulation of defense response" EXACT []
synonym: "downregulation of defense response" EXACT []
synonym: "inhibition of defense response" NARROW []
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0048585 ! negative regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006952 ! defense response
relationship: negatively_regulates GO:0006952 ! defense response

[Term]
id: GO:0031349
name: positive regulation of defense response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a defense response." [GOC:mah]
synonym: "activation of defense response" NARROW []
synonym: "stimulation of defense response" NARROW []
synonym: "up regulation of defense response" EXACT []
synonym: "up-regulation of defense response" EXACT []
synonym: "upregulation of defense response" EXACT []
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0048584 ! positive regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006952 ! defense response
relationship: positively_regulates GO:0006952 ! defense response

[Term]
id: GO:0031350
name: intrinsic component of plastid membrane
namespace: cellular_component
def: "The component of the plastid membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
synonym: "intrinsic to plastid membrane" NARROW []
is_a: GO:0031300 ! intrinsic component of organelle membrane
is_a: GO:0044435 ! plastid part
intersection_of: GO:0031224 ! intrinsic component of membrane
intersection_of: part_of GO:0042170 ! plastid membrane
relationship: part_of GO:0042170 ! plastid membrane

[Term]
id: GO:0031351
name: integral component of plastid membrane
namespace: cellular_component
def: "The component of the plastid membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]
synonym: "integral to plastid membrane" NARROW []
is_a: GO:0031301 ! integral component of organelle membrane
is_a: GO:0031350 ! intrinsic component of plastid membrane
intersection_of: GO:0016021 ! integral component of membrane
intersection_of: part_of GO:0042170 ! plastid membrane
relationship: part_of GO:0042170 ! plastid membrane

[Term]
id: GO:0031352
name: intrinsic component of plastid inner membrane
namespace: cellular_component
def: "The component of the plastid inner membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
synonym: "intrinsic to plastid inner membrane" NARROW []
is_a: GO:0031350 ! intrinsic component of plastid membrane
intersection_of: GO:0031350 ! intrinsic component of plastid membrane
intersection_of: part_of GO:0009528 ! plastid inner membrane
relationship: part_of GO:0009528 ! plastid inner membrane

[Term]
id: GO:0031353
name: integral component of plastid inner membrane
namespace: cellular_component
def: "The component of the plastid inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]
synonym: "integral to plastid inner membrane" NARROW []
is_a: GO:0031351 ! integral component of plastid membrane
is_a: GO:0031352 ! intrinsic component of plastid inner membrane
intersection_of: GO:0016021 ! integral component of membrane
intersection_of: part_of GO:0009528 ! plastid inner membrane
relationship: part_of GO:0009528 ! plastid inner membrane

[Term]
id: GO:0031354
name: intrinsic component of plastid outer membrane
namespace: cellular_component
def: "The component of the plastid outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
synonym: "intrinsic to plastid outer membrane" NARROW []
is_a: GO:0031350 ! intrinsic component of plastid membrane
intersection_of: GO:0031224 ! intrinsic component of membrane
intersection_of: part_of GO:0009527 ! plastid outer membrane
relationship: part_of GO:0009527 ! plastid outer membrane

[Term]
id: GO:0031355
name: integral component of plastid outer membrane
namespace: cellular_component
def: "The component of the plastid outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]
synonym: "integral to plastid outer membrane" NARROW []
is_a: GO:0031351 ! integral component of plastid membrane
is_a: GO:0031354 ! intrinsic component of plastid outer membrane
intersection_of: GO:0016021 ! integral component of membrane
intersection_of: part_of GO:0009527 ! plastid outer membrane
relationship: part_of GO:0009527 ! plastid outer membrane

[Term]
id: GO:0031356
name: intrinsic component of chloroplast inner membrane
namespace: cellular_component
def: "The component of the chloroplast inner membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
synonym: "intrinsic to chloroplast inner membrane" NARROW []
is_a: GO:0031352 ! intrinsic component of plastid inner membrane
is_a: GO:0044434 ! chloroplast part
intersection_of: GO:0031224 ! intrinsic component of membrane
intersection_of: part_of GO:0009706 ! chloroplast inner membrane
relationship: part_of GO:0009706 ! chloroplast inner membrane

[Term]
id: GO:0031357
name: integral component of chloroplast inner membrane
namespace: cellular_component
def: "The component of the chloroplast inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]
synonym: "integral to chloroplast inner membrane" NARROW []
is_a: GO:0031353 ! integral component of plastid inner membrane
is_a: GO:0031356 ! intrinsic component of chloroplast inner membrane
intersection_of: GO:0016021 ! integral component of membrane
intersection_of: part_of GO:0009706 ! chloroplast inner membrane
relationship: part_of GO:0009706 ! chloroplast inner membrane

[Term]
id: GO:0031358
name: intrinsic component of chloroplast outer membrane
namespace: cellular_component
def: "The component of the chloroplast outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
synonym: "intrinsic to chloroplast outer membrane" NARROW []
is_a: GO:0031354 ! intrinsic component of plastid outer membrane
is_a: GO:0044434 ! chloroplast part
intersection_of: GO:0031224 ! intrinsic component of membrane
intersection_of: part_of GO:0009707 ! chloroplast outer membrane
relationship: part_of GO:0009707 ! chloroplast outer membrane

[Term]
id: GO:0031359
name: integral component of chloroplast outer membrane
namespace: cellular_component
def: "The component of the chloroplast outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]
synonym: "integral to chloroplast outer membrane" NARROW []
is_a: GO:0031355 ! integral component of plastid outer membrane
is_a: GO:0031358 ! intrinsic component of chloroplast outer membrane
intersection_of: GO:0016021 ! integral component of membrane
intersection_of: part_of GO:0009707 ! chloroplast outer membrane
relationship: part_of GO:0009707 ! chloroplast outer membrane

[Term]
id: GO:0031360
name: intrinsic component of thylakoid membrane
namespace: cellular_component
def: "The component of the thylakoid membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
synonym: "intrinsic to thylakoid membrane" NARROW []
is_a: GO:0031224 ! intrinsic component of membrane
is_a: GO:0044436 ! thylakoid part
intersection_of: GO:0031224 ! intrinsic component of membrane
intersection_of: part_of GO:0042651 ! thylakoid membrane
relationship: part_of GO:0042651 ! thylakoid membrane

[Term]
id: GO:0031361
name: integral component of thylakoid membrane
namespace: cellular_component
def: "The component of the thylakoid membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]
synonym: "integral to thylakoid membrane" NARROW []
is_a: GO:0016021 ! integral component of membrane
is_a: GO:0031360 ! intrinsic component of thylakoid membrane
intersection_of: GO:0016021 ! integral component of membrane
intersection_of: part_of GO:0042651 ! thylakoid membrane
relationship: part_of GO:0042651 ! thylakoid membrane

[Term]
id: GO:0031362
name: anchored component of external side of plasma membrane
namespace: cellular_component
def: "The component of the plasma membrane consisting of the gene products that are tethered to the external side of the membrane only by a covalently attached anchor, such as a lipid group embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:mah]
synonym: "anchored to external leaflet of plasma membrane" EXACT [GOC:ab]
synonym: "anchored to external side of plasma membrane" EXACT []
is_a: GO:0031233 ! intrinsic component of external side of plasma membrane
is_a: GO:0046658 ! anchored component of plasma membrane
intersection_of: GO:0046658 ! anchored component of plasma membrane
intersection_of: part_of GO:0009897 ! external side of plasma membrane
relationship: part_of GO:0009897 ! external side of plasma membrane

[Term]
id: GO:0031363
name: N-terminal protein amino acid deamination
namespace: biological_process
def: "The removal of an amino group from the N-terminal amino acid residue of a protein." [GOC:mah]
subset: gosubset_prok
is_a: GO:0031365 ! N-terminal protein amino acid modification

[Term]
id: GO:0031364
name: N-terminal protein amino acid deamination, from side chain
namespace: biological_process
def: "The removal of an amino group from the side chain of an N-terminal asparagine or glutamine residue of a protein." [GOC:mah]
is_a: GO:0031363 ! N-terminal protein amino acid deamination

[Term]
id: GO:0031365
name: N-terminal protein amino acid modification
namespace: biological_process
alt_id: GO:0018409
def: "The alteration of the N-terminal amino acid residue in a protein." [GOC:mah]
subset: gosubset_prok
synonym: "peptide or protein amino-terminal blocking" RELATED []
synonym: "peptide/protein amino-terminal blocking" RELATED []
is_a: GO:0006464 ! cellular protein modification process

[Term]
id: GO:0031366
name: N-terminal peptidyl-asparagine deamination
namespace: biological_process
def: "The removal of an amino group from the side chain of an N-terminal asparagine residue of a protein." [GOC:bf, GOC:mah]
is_a: GO:0031364 ! N-terminal protein amino acid deamination, from side chain

[Term]
id: GO:0031367
name: N-terminal peptidyl-glutamine deamination
namespace: biological_process
def: "The removal of an amino group from the side chain of an N-terminal glutamine residue of a protein." [GOC:mah]
is_a: GO:0031364 ! N-terminal protein amino acid deamination, from side chain

[Term]
id: GO:0031368
name: obsolete Pro-X metallocarboxypeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of a Pro-Xaa bond by a metallopeptidase mechanism to release a C-terminal amino acid." [EC:3.4.17.16, GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "carboxypeptidase P activity" NARROW [EC:3.4.17.16]
synonym: "membrane Pro-X carboxypeptidase activity" NARROW [EC:3.4.17.16]
synonym: "membrane Pro-Xaa carboxypeptidase" NARROW []
synonym: "microsomal carboxypeptidase activity" NARROW [EC:3.4.17.16]
synonym: "Pro-X metallocarboxypeptidase activity" EXACT []
xref: EC:3.4.17.16
is_obsolete: true
consider: GO:0004181
consider: GO:0008233

[Term]
id: GO:0031369
name: translation initiation factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation." [GOC:mah]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0031370
name: eukaryotic initiation factor 4G binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with eukaryotic initiation factor 4G, a polypeptide factor involved in the initiation of ribosome-mediated translation." [GOC:mah]
synonym: "eIF4G binding" EXACT []
is_a: GO:0031369 ! translation initiation factor binding

[Term]
id: GO:0031371
name: ubiquitin conjugating enzyme complex
namespace: cellular_component
def: "Any complex that possesses ubiquitin conjugating enzyme activity." [GOC:mah]
subset: goslim_pir
synonym: "E2 complex" RELATED []
is_a: GO:0044424 ! intracellular part
is_a: GO:1990234 ! transferase complex

[Term]
id: GO:0031372
name: UBC13-MMS2 complex
namespace: cellular_component
def: "A heterodimeric ubiquitin conjugating enzyme complex that catalyzes assembly of K63-linked polyubiquitin chains, which act as a signal to promote error-free DNA postreplication repair; in Saccharomyces the complex comprises Ubc13p and Mms2p." [GOC:mah, PMID:15772086]
is_a: GO:0031371 ! ubiquitin conjugating enzyme complex

[Term]
id: GO:0031375
name: obsolete type II fatty acid synthase complex
namespace: cellular_component
def: "OBSOLETE A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity." [GOC:mah, ISBN:0471331309, ISBN:0716720094, PMID:12957385]
comment: Type II refers to the type of fatty acid synthase. Type I is in a complex, type II is not.
synonym: "type II FAS" EXACT []
synonym: "type II FAS complex" EXACT []
synonym: "type II fatty acid synthase" EXACT []
synonym: "type II fatty acid synthase complex" EXACT []
is_obsolete: true

[Term]
id: GO:0031376
name: obsolete cytosolic type II fatty acid synthase complex
namespace: cellular_component
def: "OBSOLETE A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity, located in the cytosol." [GOC:mah, ISBN:0471331309, ISBN:0716720094, PMID:12957385]
synonym: "cytosolic type II FAS complex" EXACT []
synonym: "cytosolic type II fatty acid synthase complex" EXACT []
is_obsolete: true

[Term]
id: GO:0031377
name: obsolete mitochondrial type II fatty acid synthase complex
namespace: cellular_component
def: "OBSOLETE A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity, located in the mitochondrion." [GOC:mah, ISBN:0471331309, ISBN:0716720094, PMID:12957385]
comment: Obsoleted because type II fatty acid synthases are not complexes
synonym: "mitochondrial type II FAS complex" EXACT []
synonym: "mitochondrial type II fatty acid synthase complex" EXACT []
is_obsolete: true

[Term]
id: GO:0031378
name: obsolete plastid type II fatty acid synthase complex
namespace: cellular_component
def: "OBSOLETE A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity, located in a plastid." [GOC:mah, ISBN:0471331309, ISBN:0716720094, PMID:12957385]
comment: Obsoleted because type II fatty acid synthase is not a complex.
synonym: "plastid type II FAS complex" EXACT []
synonym: "plastid type II fatty acid synthase complex" EXACT []
is_obsolete: true

[Term]
id: GO:0031379
name: RNA-directed RNA polymerase complex
namespace: cellular_component
def: "A protein complex that possesses RNA-directed RNA polymerase activity." [GOC:mah]
is_a: GO:0030880 ! RNA polymerase complex

[Term]
id: GO:0031380
name: nuclear RNA-directed RNA polymerase complex
namespace: cellular_component
def: "A complex required for RNAi mediated heterochromatin assembly. In S. pombe this contains RNA-directed RNA polymerase, a putative helicase and a protein containing a pap25 associated domain." [GOC:vw, PMID:15607976]
synonym: "Rdr1 complex" NARROW []
synonym: "RDRC" EXACT []
is_a: GO:0031379 ! RNA-directed RNA polymerase complex
is_a: GO:0044428 ! nuclear part
intersection_of: GO:0031379 ! RNA-directed RNA polymerase complex
intersection_of: part_of GO:0005634 ! nucleus
relationship: part_of GO:0005634 ! nucleus

[Term]
id: GO:0031381
name: viral RNA-directed RNA polymerase complex
namespace: cellular_component
def: "A virus-specific protein complex that possesses RNA-dependent RNA polymerase activity and replicates the genome of an RNA virus." [GOC:mah, PMID:15574411, PMID:15613301]
is_a: GO:0031379 ! RNA-directed RNA polymerase complex

[Term]
id: GO:0031382
name: mating projection assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a cell projection in response to mating pheromone. This process is observed in unicellular fungi." [GOC:mah, PMID:14734532]
synonym: "mating projection biogenesis" RELATED [GOC:mah]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
is_a: GO:0030031 ! cell projection assembly
is_a: GO:0044702 ! single organism reproductive process
relationship: part_of GO:0000753 ! cell morphogenesis involved in conjugation with cellular fusion

[Term]
id: GO:0031383
name: regulation of mating projection assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of mating projection formation by unicellular fungi." [PMID:14734532]
synonym: "regulation of mating projection biogenesis" RELATED [GOC:mah]
is_a: GO:0022604 ! regulation of cell morphogenesis
is_a: GO:0031137 ! regulation of conjugation with cellular fusion
is_a: GO:0048583 ! regulation of response to stimulus
is_a: GO:0060491 ! regulation of cell projection assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031382 ! mating projection assembly
relationship: regulates GO:0031382 ! mating projection assembly

[Term]
id: GO:0031384
name: regulation of initiation of mating projection growth
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the start of mating projection formation by unicellular fungi." [PMID:14734532]
is_a: GO:0031383 ! regulation of mating projection assembly

[Term]
id: GO:0031385
name: regulation of termination of mating projection growth
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the end of mating projection formation by unicellular fungi." [PMID:14734532]
is_a: GO:0031383 ! regulation of mating projection assembly

[Term]
id: GO:0031386
name: protein tag
namespace: molecular_function
def: "Acting as an indicator or marker to facilitate recognition by other molecules in the cell. Recognition of the tag, which can be covalently attached to the target molecule, may result in modification, sequestration, transport or degradation of the molecule in question." [GOC:go_curators]
subset: goslim_pir
synonym: "covalent modifier" RELATED [GOC:vw]
synonym: "protein tagging activity" RELATED []
synonym: "ubiquitin" RELATED []
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0031387
name: MPF complex
namespace: cellular_component
def: "A complex consisting of a Cdc2-class (also known as Cdc28) cyclin-dependent kinase and an M-phase cyclin such as S. pombe Cdc13. The MPF complex phosphorylates and activates the anaphase promoting complex (APC)." [PMID:12045216]
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex

[Term]
id: GO:0031388
name: organic acid phosphorylation
namespace: biological_process
def: "The process of introducing one or more phosphate groups into an organic acid." [GOC:mah]
is_a: GO:0006082 ! organic acid metabolic process
is_a: GO:0016310 ! phosphorylation

[Term]
id: GO:0031389
name: Rad17 RFC-like complex
namespace: cellular_component
def: "A pentameric protein complex related to replication factor C, which loads a trimeric complex of checkpoint proteins (known as the checkpoint clamp or 9-1-1 complex) onto DNA at damage sites; functions in DNA damage cell cycle checkpoints. In Schizosaccharomyces pombe the subunits are known as Rad17, Rfc2, Rfc3, Rfc4, and Rfc5, while in Saccharomyces cerevisiae the subunits are known as Rad24p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p." [PMID:14614842]
synonym: "Rad17-RFC" EXACT []
synonym: "Rad17-RLC" EXACT []
synonym: "Rad24p RFC-like complex" EXACT []
synonym: "RFC (Rad17)" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part

[Term]
id: GO:0031390
name: Ctf18 RFC-like complex
namespace: cellular_component
def: "A heptameric complex related to replication factor C, which loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA and plays a vital role in chromosome cohesion. In Saccharomyces the subunits are known as Ctf18p, Rfc2p, Rfc3p, Rfc4p, Rfc5p, Dcc1p, and Ctf8p." [PMID:14614842]
synonym: "Ctf18-RFC" EXACT []
synonym: "Ctf18-RLC" EXACT []
synonym: "RFC (Ctf18)" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part

[Term]
id: GO:0031391
name: Elg1 RFC-like complex
namespace: cellular_component
def: "A pentameric complex related to replication factor C, which loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA and has roles in telomere length regulation and other aspects of genome stability. In Saccharomyces the subunits are known as Elg1p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p." [PMID:14614842]
synonym: "Elg1-RFC" EXACT []
synonym: "Elg1-RLC" EXACT []
synonym: "RFC (Elg1)" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part

[Term]
id: GO:0031392
name: regulation of prostaglandin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin." [GOC:mah]
synonym: "regulation of prostaglandin anabolism" EXACT []
synonym: "regulation of prostaglandin biosynthesis" EXACT []
synonym: "regulation of prostaglandin formation" EXACT []
synonym: "regulation of prostaglandin synthesis" EXACT []
is_a: GO:2001279 ! regulation of unsaturated fatty acid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001516 ! prostaglandin biosynthetic process
relationship: regulates GO:0001516 ! prostaglandin biosynthetic process

[Term]
id: GO:0031393
name: negative regulation of prostaglandin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin." [GOC:mah]
synonym: "down regulation of prostaglandin biosynthetic process" EXACT []
synonym: "down-regulation of prostaglandin biosynthetic process" EXACT []
synonym: "downregulation of prostaglandin biosynthetic process" EXACT []
synonym: "inhibition of prostaglandin biosynthetic process" NARROW []
synonym: "negative regulation of prostaglandin anabolism" EXACT []
synonym: "negative regulation of prostaglandin biosynthesis" EXACT []
synonym: "negative regulation of prostaglandin formation" EXACT []
synonym: "negative regulation of prostaglandin synthesis" EXACT []
is_a: GO:0031392 ! regulation of prostaglandin biosynthetic process
is_a: GO:0045717 ! negative regulation of fatty acid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001516 ! prostaglandin biosynthetic process
relationship: negatively_regulates GO:0001516 ! prostaglandin biosynthetic process

[Term]
id: GO:0031394
name: positive regulation of prostaglandin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin." [GOC:mah]
synonym: "activation of prostaglandin biosynthetic process" NARROW []
synonym: "positive regulation of prostaglandin anabolism" EXACT []
synonym: "positive regulation of prostaglandin biosynthesis" EXACT []
synonym: "positive regulation of prostaglandin formation" EXACT []
synonym: "positive regulation of prostaglandin synthesis" EXACT []
synonym: "stimulation of prostaglandin biosynthetic process" NARROW []
synonym: "up regulation of prostaglandin biosynthetic process" EXACT []
synonym: "up-regulation of prostaglandin biosynthetic process" EXACT []
synonym: "upregulation of prostaglandin biosynthetic process" EXACT []
is_a: GO:0031392 ! regulation of prostaglandin biosynthetic process
is_a: GO:2001280 ! positive regulation of unsaturated fatty acid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001516 ! prostaglandin biosynthetic process
relationship: positively_regulates GO:0001516 ! prostaglandin biosynthetic process

[Term]
id: GO:0031395
name: bursicon neuropeptide hormone complex
namespace: cellular_component
def: "A neuropeptide hormone secreted by the central nervous system of insects that stimulates the tanning and sclerotization of the adult cuticle following eclosion. The active hormone consists of an obligate heterodimer of the alpha and beta subunits." [GOC:rc]
is_a: GO:0043234 ! protein complex
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0031396
name: regulation of protein ubiquitination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah]
is_a: GO:1903320 ! regulation of protein modification by small protein conjugation or removal
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016567 ! protein ubiquitination
relationship: regulates GO:0016567 ! protein ubiquitination

[Term]
id: GO:0031397
name: negative regulation of protein ubiquitination
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah]
synonym: "down regulation of protein ubiquitination" EXACT []
synonym: "down-regulation of protein ubiquitination" EXACT []
synonym: "downregulation of protein ubiquitination" EXACT []
synonym: "inhibition of protein ubiquitination" NARROW []
is_a: GO:0031396 ! regulation of protein ubiquitination
is_a: GO:1903321 ! negative regulation of protein modification by small protein conjugation or removal
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016567 ! protein ubiquitination
relationship: negatively_regulates GO:0016567 ! protein ubiquitination

[Term]
id: GO:0031398
name: positive regulation of protein ubiquitination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah]
synonym: "activation of protein ubiquitination" NARROW []
synonym: "stimulation of protein ubiquitination" NARROW []
synonym: "up regulation of protein ubiquitination" EXACT []
synonym: "up-regulation of protein ubiquitination" EXACT []
synonym: "upregulation of protein ubiquitination" EXACT []
is_a: GO:0031396 ! regulation of protein ubiquitination
is_a: GO:1903322 ! positive regulation of protein modification by small protein conjugation or removal
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016567 ! protein ubiquitination
relationship: positively_regulates GO:0016567 ! protein ubiquitination

[Term]
id: GO:0031399
name: regulation of protein modification process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb]
subset: goslim_yeast
subset: gosubset_prok
is_a: GO:0032268 ! regulation of cellular protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006464 ! cellular protein modification process
relationship: regulates GO:0006464 ! cellular protein modification process

[Term]
id: GO:0031400
name: negative regulation of protein modification process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb]
synonym: "down regulation of protein modification" EXACT []
synonym: "down-regulation of protein modification" EXACT []
synonym: "downregulation of protein modification" EXACT []
synonym: "inhibition of protein modification" NARROW []
is_a: GO:0031399 ! regulation of protein modification process
is_a: GO:0032269 ! negative regulation of cellular protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006464 ! cellular protein modification process
relationship: negatively_regulates GO:0006464 ! cellular protein modification process

[Term]
id: GO:0031401
name: positive regulation of protein modification process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb]
synonym: "activation of protein modification" NARROW []
synonym: "stimulation of protein modification" NARROW []
synonym: "up regulation of protein modification" EXACT []
synonym: "up-regulation of protein modification" EXACT []
synonym: "upregulation of protein modification" EXACT []
is_a: GO:0031399 ! regulation of protein modification process
is_a: GO:0032270 ! positive regulation of cellular protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006464 ! cellular protein modification process
relationship: positively_regulates GO:0006464 ! cellular protein modification process

[Term]
id: GO:0031402
name: sodium ion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with sodium ions (Na+)." [GOC:mah]
subset: gosubset_prok
is_a: GO:0031420 ! alkali metal ion binding

[Term]
id: GO:0031403
name: lithium ion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with lithium ions (Li+)." [GOC:mah]
subset: gosubset_prok
is_a: GO:0031420 ! alkali metal ion binding

[Term]
id: GO:0031404
name: chloride ion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with chloride ions (Cl-)." [GOC:mah]
subset: gosubset_prok
synonym: "chloride binding" EXACT []
is_a: GO:0043168 ! anion binding

[Term]
id: GO:0031405
name: lipoic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with lipoic acid, 1,2-dithiolane-3-pentanoic acid." [GOC:mah, ISBN:0198506732]
is_a: GO:0005504 ! fatty acid binding
is_a: GO:0050662 ! coenzyme binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding
is_a: GO:1901681 ! sulfur compound binding

[Term]
id: GO:0031406
name: carboxylic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a carboxylic acid, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:mah, ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0043168 ! anion binding
is_a: GO:0043177 ! organic acid binding

[Term]
id: GO:0031407
name: oxylipin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any oxylipin, any of a group of biologically active compounds formed by oxidative metabolism of polyunsaturated fatty acids." [GOC:mah, PMID:11960741]
subset: gosubset_prok
synonym: "oxylipin metabolism" EXACT []
is_a: GO:0006631 ! fatty acid metabolic process

[Term]
id: GO:0031408
name: oxylipin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any oxylipin, any of a group of biologically active compounds formed by oxidative metabolism of polyunsaturated fatty acids." [GOC:mah, PMID:11960741]
synonym: "oxylipin anabolism" EXACT []
synonym: "oxylipin biosynthesis" EXACT []
synonym: "oxylipin formation" EXACT []
synonym: "oxylipin synthesis" EXACT []
is_a: GO:0006633 ! fatty acid biosynthetic process
is_a: GO:0031407 ! oxylipin metabolic process

[Term]
id: GO:0031409
name: pigment binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [GOC:mah]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0031410
name: cytoplasmic vesicle
namespace: cellular_component
def: "A vesicle found in the cytoplasm of a cell." [GOC:mah, GOC:vesicles]
subset: gosubset_prok
xref: NIF_Subcellular:sao180601769
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0097708 ! intracellular vesicle
intersection_of: GO:0031982 ! vesicle
intersection_of: part_of GO:0005737 ! cytoplasm
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0031411
name: gas vesicle
namespace: cellular_component
def: "An intracellular non-membrane-bounded organelle; a hollow structure made of protein, which usually has the form of a cylindrical tube closed by conical end caps. By regulating their relative gas vesicle content, aquatic microbes are able to perform vertical migrations." [PMID:22147705, PMID:8177173]
comment: Note that although this organelle is commonly referred to as a 'vesicle' or 'vacuole' in the literature, it is not surrounded by a membrane.
subset: gosubset_prok
synonym: "gas vacuole" RELATED [GOC:pr]
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle

[Term]
id: GO:0031412
name: gas vesicle organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a gas vesicle. A gas vesicle is a hollow structure made of protein, which usually has the form of a cylindrical tube closed by conical end caps." [GOC:mah]
comment: Note that although gas vesicles are commonly referred to as 'vesicles' or 'vacuoles' in the literature, they are not surrounded by a membrane.
synonym: "gas vesicle biosynthesis" NARROW [GOC:mah]
synonym: "gas vesicle formation" NARROW [GOC:mah]
synonym: "gas vesicle organisation" EXACT [GOC:curators]
synonym: "gas vesicle organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0031413
name: regulation of buoyancy
namespace: biological_process
def: "Any process that modulates an organism's tendency or ability to rise or float in a fluid medium such as water or air, often through the use of stored gases." [GOC:mah, PATO:0001420]
synonym: "buoyancy regulation" EXACT []
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0031414
name: N-terminal protein acetyltransferase complex
namespace: cellular_component
def: "A complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule." [GOC:mah]
synonym: "NAT complex" EXACT []
is_a: GO:0031248 ! protein acetyltransferase complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0031415
name: NatA complex
namespace: cellular_component
def: "A conserved complex that catalyzes the transfer of an acetyl group to an N-terminal Ser, Ala, Gly, or Thr residue of a protein acceptor molecule. In Saccharomyces the complex includes Nat1p and Ard1p, and may contain additional proteins." [PMID:12890471]
synonym: "N-terminal acetyltransferase A complex" EXACT []
is_a: GO:0031414 ! N-terminal protein acetyltransferase complex

[Term]
id: GO:0031416
name: NatB complex
namespace: cellular_component
def: "A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Glu, Met-Asp, Met-Asn, or Met-Met N-terminus. In Saccharomyces the complex includes Nat3p and Mdm20p." [PMID:12890471]
synonym: "N-terminal acetyltransferase B complex" EXACT []
is_a: GO:0031414 ! N-terminal protein acetyltransferase complex

[Term]
id: GO:0031417
name: NatC complex
namespace: cellular_component
def: "A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Ile, Met-Leu, Met-Trp, or Met-Phe N-terminus. In Saccharomyces the complex includes Mak3p, Mak10p, and Mak31p." [PMID:12890471]
synonym: "N-terminal acetyltransferase C complex" EXACT []
is_a: GO:0031414 ! N-terminal protein acetyltransferase complex

[Term]
id: GO:0031418
name: L-ascorbic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [CHEBI:38290, GOC:mah]
synonym: "L-ascorbate binding" EXACT []
synonym: "vitamin C binding" EXACT []
is_a: GO:0019842 ! vitamin binding
is_a: GO:0031406 ! carboxylic acid binding
is_a: GO:0048029 ! monosaccharide binding

[Term]
id: GO:0031419
name: cobalamin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:mah]
synonym: "vitamin B12 binding" EXACT []
is_a: GO:0019842 ! vitamin binding
is_a: GO:0046906 ! tetrapyrrole binding

[Term]
id: GO:0031420
name: alkali metal ion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any alkali metal ion; alkali metals are those elements in group Ia of the periodic table, with the exception of hydrogen." [GOC:mah]
subset: gosubset_prok
is_a: GO:0046872 ! metal ion binding

[Term]
id: GO:0031421
name: invertasome
namespace: cellular_component
def: "A complex formed by a recombinase, a regulatory protein, and the DNA sequences bound by each protein; catalyzes a reversible site-specific recombination reaction that results in the alternate expression of one or more genes in various contexts." [PMID:11114897, PMID:9732277]
is_a: GO:0032993 ! protein-DNA complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0031422
name: RecQ helicase-Topo III complex
namespace: cellular_component
def: "A complex containing a RecQ family helicase and a topoisomerase III homologue; may also include one or more additional proteins; conserved from E. coli to human." [PMID:15889139]
synonym: "Sgs1-Top3 complex" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part

[Term]
id: GO:0031423
name: hexon binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a hexon, the major protein component of the icosahedral capsid of an adenovirus." [GOC:mah, PMID:12915569]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0031424
name: keratinization
namespace: biological_process
def: "The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns." [GOC:dph, GOC:ebc, GOC:sdb_2009, GOC:tb]
is_a: GO:0044707 ! single-multicellular organism process
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0030216 ! keratinocyte differentiation

[Term]
id: GO:0031425
name: chloroplast RNA processing
namespace: biological_process
def: "The conversion of a primary RNA molecule transcribed from a chloroplast genome into one or more mature RNA molecules." [GOC:mah]
is_a: GO:0006396 ! RNA processing

[Term]
id: GO:0031426
name: polycistronic mRNA processing
namespace: biological_process
def: "The conversion of a primary mRNA transcript containing more than one complete protein-coding region into individual mature mRNA molecules." [GOC:mah]
is_a: GO:0006397 ! mRNA processing

[Term]
id: GO:0031427
name: response to methotrexate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase." [CHEBI:44185, GOC:ef, GOC:mah, ISBN:0198506732]
is_a: GO:0001101 ! response to acid chemical
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0031428
name: box C/D snoRNP complex
namespace: cellular_component
def: "A ribonucleoprotein complex containing small nucleolar RNA of the box C/D type that can carry out ribose-2'-O-methylation of target RNAs." [ISBN:0879695897, PMID:17284456]
synonym: "box C/D small nucleolar ribonucleoprotein complex" EXACT [GOC:cjm]
synonym: "box C/D snoRNP ribose 2'-O methylase complex" EXACT [PMID:17284456]
synonym: "box C/D snoRNP ribose-2'-O-methyltransferase complex" EXACT [PMID:17284456]
is_a: GO:0005732 ! small nucleolar ribonucleoprotein complex
is_a: GO:0044452 ! nucleolar part

[Term]
id: GO:0031429
name: box H/ACA snoRNP complex
namespace: cellular_component
def: "A box H/ACA RNP complex that is located in the nucleolus." [GOC:vw, ISBN:0879695897, PMID:17284456, PMID:20227365]
synonym: "box H/ACA small nucleolar ribonucleoprotein complex" EXACT [GOC:cjm]
synonym: "box H/ACA snoRNP pseudouridylase complex" EXACT [GOC:mah, GOC:vw, PMID:17284456]
is_a: GO:0044452 ! nucleolar part
is_a: GO:0072588 ! box H/ACA RNP complex

[Term]
id: GO:0031430
name: M band
namespace: cellular_component
def: "The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines." [GOC:mtg_muscle, ISBN:0198506732, ISBN:0815316194]
synonym: "M disc" EXACT []
synonym: "M line" NARROW []
synonym: "mesophragma" EXACT []
synonym: "midline" BROAD []
xref: Wikipedia:Sarcomere#bands
is_a: GO:0044449 ! contractile fiber part
relationship: part_of GO:0031672 ! A band

[Term]
id: GO:0031431
name: Dbf4-dependent protein kinase complex
namespace: cellular_component
def: "A heterodimeric protein complex required for the activation of DNA replication origins; comprises a catalytic subunit and a regulatory subunit (in Saccharomyces, Cdc7p and Dbf4p, respectively); complexes identified in other species generally contain proteins related to the Saccharomyces proteins." [PMID:12045100]
synonym: "Cdc7-Dbf4 complex" NARROW []
synonym: "DDK" EXACT []
synonym: "Hsk1-Dfp1 kinase complex" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0031432
name: titin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with titin, any of a family of giant proteins found in striated and smooth muscle. In striated muscle, single titin molecules span half the sarcomere, with their N- and C-termini in the Z-disc and M-line, respectively." [GOC:mah, PMID:10481174]
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0031433
name: telethonin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with telethonin, a protein found in the Z disc of striated muscle and which is a substrate of the titin kinase." [GOC:mah, PMID:10481174]
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0031434
name: mitogen-activated protein kinase kinase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase, any protein that can phosphorylate a MAP kinase." [GOC:mah]
synonym: "MAPKK binding" EXACT []
is_a: GO:0019901 ! protein kinase binding

[Term]
id: GO:0031435
name: mitogen-activated protein kinase kinase kinase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase kinase, any protein that can phosphorylate a MAP kinase kinase." [GOC:bf]
synonym: "MAPKKK binding" EXACT []
is_a: GO:0019901 ! protein kinase binding

[Term]
id: GO:0031436
name: BRCA1-BARD1 complex
namespace: cellular_component
def: "A heterodimeric complex comprising BRCA1 and BARD1, which possesses ubiquitin ligase activity and is involved in genome maintenance, possibly by functioning in surveillance for DNA damage." [PMID:12787778]
is_a: GO:0000152 ! nuclear ubiquitin ligase complex

[Term]
id: GO:0031437
name: regulation of mRNA cleavage
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mRNA cleavage, any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner." [GOC:mah]
is_a: GO:0050684 ! regulation of mRNA processing
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006379 ! mRNA cleavage
relationship: regulates GO:0006379 ! mRNA cleavage

[Term]
id: GO:0031438
name: negative regulation of mRNA cleavage
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mRNA cleavage." [GOC:mah]
synonym: "down regulation of mRNA cleavage" EXACT []
synonym: "down-regulation of mRNA cleavage" EXACT []
synonym: "downregulation of mRNA cleavage" EXACT []
synonym: "inhibition of mRNA cleavage" NARROW []
is_a: GO:0031437 ! regulation of mRNA cleavage
is_a: GO:0050686 ! negative regulation of mRNA processing
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006379 ! mRNA cleavage
relationship: negatively_regulates GO:0006379 ! mRNA cleavage

[Term]
id: GO:0031439
name: positive regulation of mRNA cleavage
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mRNA cleavage." [GOC:mah]
synonym: "activation of mRNA cleavage" NARROW []
synonym: "stimulation of mRNA cleavage" NARROW []
synonym: "up regulation of mRNA cleavage" EXACT []
synonym: "up-regulation of mRNA cleavage" EXACT []
synonym: "upregulation of mRNA cleavage" EXACT []
is_a: GO:0031437 ! regulation of mRNA cleavage
is_a: GO:0050685 ! positive regulation of mRNA processing
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006379 ! mRNA cleavage
relationship: positively_regulates GO:0006379 ! mRNA cleavage

[Term]
id: GO:0031440
name: regulation of mRNA 3'-end processing
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mRNA 3'-end processing, any process involved in forming the mature 3' end of an mRNA molecule." [GOC:mah]
is_a: GO:0050684 ! regulation of mRNA processing
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031124 ! mRNA 3'-end processing
relationship: regulates GO:0031124 ! mRNA 3'-end processing

[Term]
id: GO:0031441
name: negative regulation of mRNA 3'-end processing
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mRNA 3'-end processing." [GOC:mah]
synonym: "down regulation of mRNA 3'-end processing" EXACT []
synonym: "down-regulation of mRNA 3'-end processing" EXACT []
synonym: "downregulation of mRNA 3'-end processing" EXACT []
synonym: "inhibition of mRNA 3'-end processing" NARROW []
is_a: GO:0031440 ! regulation of mRNA 3'-end processing
is_a: GO:0050686 ! negative regulation of mRNA processing
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0031124 ! mRNA 3'-end processing
relationship: negatively_regulates GO:0031124 ! mRNA 3'-end processing

[Term]
id: GO:0031442
name: positive regulation of mRNA 3'-end processing
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mRNA 3'-end processing." [GOC:mah]
synonym: "activation of mRNA 3'-end processing" NARROW []
synonym: "stimulation of mRNA 3'-end processing" NARROW []
synonym: "up regulation of mRNA 3'-end processing" EXACT []
synonym: "up-regulation of mRNA 3'-end processing" EXACT []
synonym: "upregulation of mRNA 3'-end processing" EXACT []
is_a: GO:0031440 ! regulation of mRNA 3'-end processing
is_a: GO:0050685 ! positive regulation of mRNA processing
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0031124 ! mRNA 3'-end processing
relationship: positively_regulates GO:0031124 ! mRNA 3'-end processing

[Term]
id: GO:0031443
name: fast-twitch skeletal muscle fiber contraction
namespace: biological_process
def: "A process in which force is generated within fast-twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The fast-twitch skeletal muscle is characterized by fast time parameters, high force development and fatiguability." [GOC:ef, GOC:mah, GOC:mtg_muscle]
synonym: "fast-twitch skeletal fiber contraction" EXACT []
synonym: "fast-twitch skeletal fibre contraction" EXACT []
synonym: "fast-twitch skeletal muscle fibre contraction" EXACT []
synonym: "fast-twitch skeletal myofiber contraction" EXACT []
synonym: "fast-twitch skeletal myofibre contraction" EXACT []
is_a: GO:0014721 ! twitch skeletal muscle contraction

[Term]
id: GO:0031444
name: slow-twitch skeletal muscle fiber contraction
namespace: biological_process
def: "A process in which force is generated within slow-twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The slow-twitch skeletal muscle is characterized by slow time parameters, low force development and resistance to fatigue." [GOC:ef, GOC:mah, GOC:mtg_muscle]
synonym: "slow-twitch skeletal muscle fibre contraction" EXACT []
is_a: GO:0014721 ! twitch skeletal muscle contraction

[Term]
id: GO:0031445
name: regulation of heterochromatin assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate, extent or location of heterochromatin formation." [GOC:mah]
synonym: "regulation of heterochromatin formation" EXACT []
is_a: GO:0010847 ! regulation of chromatin assembly
is_a: GO:1903308 ! regulation of chromatin modification
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031507 ! heterochromatin assembly
relationship: regulates GO:0031507 ! heterochromatin assembly

[Term]
id: GO:0031446
name: regulation of fast-twitch skeletal muscle fiber contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fast-twitch skeletal muscle contraction." [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb]
synonym: "regulation of fast-twitch skeletal muscle contraction" EXACT [GOC:dph, GOC:tb]
is_a: GO:0014724 ! regulation of twitch skeletal muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031443 ! fast-twitch skeletal muscle fiber contraction
relationship: regulates GO:0031443 ! fast-twitch skeletal muscle fiber contraction

[Term]
id: GO:0031447
name: negative regulation of fast-twitch skeletal muscle fiber contraction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of fast-twitch skeletal muscle contraction." [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb]
synonym: "down regulation of fast-twitch skeletal muscle contraction" EXACT []
synonym: "down-regulation of fast-twitch skeletal muscle contraction" EXACT []
synonym: "downregulation of fast-twitch skeletal muscle contraction" EXACT []
synonym: "inhibition of fast-twitch skeletal muscle contraction" NARROW []
synonym: "negative regulation of fast-twitch skeletal muscle contraction" EXACT [GOC:dph, GOC:tb]
is_a: GO:0031446 ! regulation of fast-twitch skeletal muscle fiber contraction
is_a: GO:0045988 ! negative regulation of striated muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0031443 ! fast-twitch skeletal muscle fiber contraction
relationship: negatively_regulates GO:0031443 ! fast-twitch skeletal muscle fiber contraction

[Term]
id: GO:0031448
name: positive regulation of fast-twitch skeletal muscle fiber contraction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of fast-twitch skeletal muscle contraction." [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb]
synonym: "activation of fast-twitch skeletal muscle contraction" NARROW []
synonym: "positive regulation of fast-twitch skeletal muscle contraction" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of fast-twitch skeletal muscle contraction" NARROW []
synonym: "up regulation of fast-twitch skeletal muscle contraction" EXACT []
synonym: "up-regulation of fast-twitch skeletal muscle contraction" EXACT []
synonym: "upregulation of fast-twitch skeletal muscle contraction" EXACT []
is_a: GO:0031446 ! regulation of fast-twitch skeletal muscle fiber contraction
is_a: GO:0045989 ! positive regulation of striated muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0031443 ! fast-twitch skeletal muscle fiber contraction
relationship: positively_regulates GO:0031443 ! fast-twitch skeletal muscle fiber contraction

[Term]
id: GO:0031449
name: regulation of slow-twitch skeletal muscle fiber contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of slow-twitch skeletal muscle contraction." [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb]
synonym: "regulation of slow-twitch skeletal muscle contraction" EXACT [GOC:dph, GOC:tb]
is_a: GO:0014724 ! regulation of twitch skeletal muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031444 ! slow-twitch skeletal muscle fiber contraction
relationship: regulates GO:0031444 ! slow-twitch skeletal muscle fiber contraction

[Term]
id: GO:0031450
name: negative regulation of slow-twitch skeletal muscle fiber contraction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of slow-twitch skeletal muscle contraction." [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb]
synonym: "down regulation of slow-twitch skeletal muscle contraction" EXACT []
synonym: "down-regulation of slow-twitch skeletal muscle contraction" EXACT []
synonym: "downregulation of slow-twitch skeletal muscle contraction" EXACT []
synonym: "inhibition of slow-twitch skeletal muscle contraction" NARROW []
synonym: "negative regulation of slow-twitch skeletal muscle contraction" EXACT [GOC:dph, GOC:tb]
is_a: GO:0031449 ! regulation of slow-twitch skeletal muscle fiber contraction
is_a: GO:0045988 ! negative regulation of striated muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0031444 ! slow-twitch skeletal muscle fiber contraction
relationship: negatively_regulates GO:0031444 ! slow-twitch skeletal muscle fiber contraction

[Term]
id: GO:0031451
name: positive regulation of slow-twitch skeletal muscle fiber contraction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of slow-twitch skeletal muscle contraction." [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb]
synonym: "activation of slow-twitch skeletal muscle contraction" NARROW []
synonym: "positive regulation of slow-twitch skeletal muscle contraction" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of slow-twitch skeletal muscle contraction" NARROW []
synonym: "up regulation of slow-twitch skeletal muscle contraction" EXACT []
synonym: "up-regulation of slow-twitch skeletal muscle contraction" EXACT []
synonym: "upregulation of slow-twitch skeletal muscle contraction" EXACT []
is_a: GO:0031449 ! regulation of slow-twitch skeletal muscle fiber contraction
is_a: GO:0045989 ! positive regulation of striated muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0031444 ! slow-twitch skeletal muscle fiber contraction
relationship: positively_regulates GO:0031444 ! slow-twitch skeletal muscle fiber contraction

[Term]
id: GO:0031452
name: negative regulation of heterochromatin assembly
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of heterochromatin formation." [GOC:mah]
synonym: "down regulation of heterochromatin formation" EXACT []
synonym: "down-regulation of heterochromatin formation" EXACT []
synonym: "downregulation of heterochromatin formation" EXACT []
synonym: "inhibition of heterochromatin formation" NARROW []
synonym: "negative regulation of heterochromatin formation" EXACT []
is_a: GO:0031445 ! regulation of heterochromatin assembly
is_a: GO:0045798 ! negative regulation of chromatin assembly or disassembly
is_a: GO:1903309 ! negative regulation of chromatin modification
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0031507 ! heterochromatin assembly
relationship: negatively_regulates GO:0031507 ! heterochromatin assembly

[Term]
id: GO:0031453
name: positive regulation of heterochromatin assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of heterochromatin formation." [GOC:mah]
synonym: "activation of heterochromatin formation" NARROW []
synonym: "positive regulation of heterochromatin formation" EXACT []
synonym: "stimulation of heterochromatin formation" NARROW []
synonym: "up regulation of heterochromatin formation" EXACT []
synonym: "up-regulation of heterochromatin formation" EXACT []
synonym: "upregulation of heterochromatin formation" EXACT []
is_a: GO:0031445 ! regulation of heterochromatin assembly
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:0045799 ! positive regulation of chromatin assembly or disassembly
is_a: GO:1903310 ! positive regulation of chromatin modification
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0031507 ! heterochromatin assembly
relationship: positively_regulates GO:0031507 ! heterochromatin assembly

[Term]
id: GO:0031454
name: regulation of extent of heterochromatin assembly
namespace: biological_process
def: "Any process that modulates the extent or location of heterochromatin formation." [GOC:mah]
synonym: "regulation of extent of heterochromatin formation" EXACT []
synonym: "regulation of heterochromatin spreading" RELATED []
is_a: GO:0031445 ! regulation of heterochromatin assembly

[Term]
id: GO:0031455
name: glycine betaine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycine betaine, N-trimethylglycine." [GOC:mah]
subset: gosubset_prok
synonym: "glycine betaine metabolism" EXACT []
synonym: "N-trimethylglycine metabolic process" EXACT []
synonym: "N-trimethylglycine metabolism" EXACT []
is_a: GO:0006575 ! cellular modified amino acid metabolic process
is_a: GO:0006577 ! amino-acid betaine metabolic process
is_a: GO:0097164 ! ammonium ion metabolic process

[Term]
id: GO:0031456
name: glycine betaine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycine betaine, N-trimethylglycine." [GOC:mah]
subset: gosubset_prok
synonym: "glycine betaine anabolism" EXACT []
synonym: "glycine betaine biosynthesis" EXACT []
synonym: "glycine betaine formation" EXACT []
synonym: "glycine betaine synthesis" EXACT []
synonym: "N-trimethylglycine biosynthesis" EXACT []
synonym: "N-trimethylglycine biosynthetic process" EXACT []
is_a: GO:0006578 ! amino-acid betaine biosynthetic process
is_a: GO:0031455 ! glycine betaine metabolic process
is_a: GO:0042398 ! cellular modified amino acid biosynthetic process

[Term]
id: GO:0031457
name: glycine betaine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycine betaine, N-trimethylglycine." [GOC:mah]
synonym: "glycine betaine breakdown" EXACT []
synonym: "glycine betaine catabolism" EXACT []
synonym: "glycine betaine degradation" EXACT []
synonym: "N-trimethylglycine catabolic process" EXACT []
synonym: "N-trimethylglycine catabolism" EXACT []
is_a: GO:0006579 ! amino-acid betaine catabolic process
is_a: GO:0031455 ! glycine betaine metabolic process
is_a: GO:0042219 ! cellular modified amino acid catabolic process

[Term]
id: GO:0031458
name: betaine-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O + a betaine(out) = ADP + phosphate + a betaine(in)." [GOC:mlg]
synonym: "betaine ABC transporter" NARROW []
is_a: GO:0015199 ! amino-acid betaine transmembrane transporter activity
is_a: GO:0019829 ! cation-transporting ATPase activity
is_a: GO:0031263 ! amine-transporting ATPase activity

[Term]
id: GO:0031459
name: glycine betaine-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O + glycine betaine(out) = ADP + phosphate + glycine betaine(in)." [GOC:mlg]
synonym: "glycine betaine ABC transporter" NARROW []
synonym: "N-trimethylglycine-transporting ATPase activity" EXACT []
xref: RHEA:32786
is_a: GO:0031458 ! betaine-transporting ATPase activity
relationship: part_of GO:0031460 ! glycine betaine transport

[Term]
id: GO:0031460
name: glycine betaine transport
namespace: biological_process
def: "The directed movement of glycine betaine, N-trimethylglycine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "N-trimethylglycine transport" EXACT []
is_a: GO:0015696 ! ammonium transport
is_a: GO:0015838 ! amino-acid betaine transport
is_a: GO:0072337 ! modified amino acid transport

[Term]
id: GO:0031461
name: cullin-RING ubiquitin ligase complex
namespace: cellular_component
def: "Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity." [PMID:15571813, PMID:15688063]
synonym: "CRL complex" EXACT []
synonym: "cullin complex" EXACT []
synonym: "cullin-RING ligase" RELATED []
is_a: GO:0000151 ! ubiquitin ligase complex

[Term]
id: GO:0031462
name: Cul2-RING ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein." [PMID:15571813, PMID:15688063]
synonym: "CBC complex" BROAD []
synonym: "CDL2 complex" EXACT []
synonym: "CRL2 complex" EXACT []
synonym: "cullin-RING ligase 2" EXACT []
synonym: "EC2S complex" BROAD []
synonym: "ECS complex" BROAD []
synonym: "SCF2 complex" RELATED []
synonym: "VBC complex" NARROW []
is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex

[Term]
id: GO:0031463
name: Cul3-RING ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein." [PMID:15571813, PMID:15688063]
synonym: "BC3B complex" EXACT []
synonym: "BCR3 complex" EXACT []
synonym: "CDL3 complex" EXACT []
synonym: "CRL3 complex" EXACT []
synonym: "cullin-RING ligase 3" EXACT []
synonym: "SCF3 complex" RELATED []
is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex

[Term]
id: GO:0031464
name: Cul4A-RING E3 ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex in which a cullin from the Cul4A subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:15571813, PMID:15688063]
synonym: "CDL4 complex" EXACT []
synonym: "CRL4 complex" EXACT []
synonym: "cullin-RING ligase 4A" EXACT []
synonym: "DCX complex" EXACT []
synonym: "SCF4 complex" RELATED []
synonym: "VDC complex" NARROW []
is_a: GO:0080008 ! Cul4-RING E3 ubiquitin ligase complex

[Term]
id: GO:0031465
name: Cul4B-RING E3 ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex in which a cullin from the Cul4B subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by unknown subunits." [PMID:15571813, PMID:15688063]
synonym: "cullin-RING ligase 4B" EXACT []
is_a: GO:0080008 ! Cul4-RING E3 ubiquitin ligase complex

[Term]
id: GO:0031466
name: Cul5-RING ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex in which a cullin from the Cul5 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein." [PMID:15571813, PMID:15688063]
synonym: "CDL5 complex" EXACT []
synonym: "CRL5 complex" EXACT []
synonym: "cullin-RING ligase 5" EXACT []
synonym: "EC2S complex" BROAD []
synonym: "SCF5 complex" RELATED []
is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex

[Term]
id: GO:0031467
name: Cul7-RING ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex in which a cullin from the Cul7 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 linker and an F-box protein." [PMID:15571813, PMID:15688063]
synonym: "CDL7 complex" EXACT []
synonym: "CRL7 complex" EXACT []
synonym: "cullin-RING ligase 7" EXACT []
synonym: "SCF7 complex" EXACT []
is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex

[Term]
id: GO:0031468
name: nuclear envelope reassembly
namespace: biological_process
def: "The reformation of the nuclear envelope following its breakdown in the context of a normal process." [GOC:mah]
is_a: GO:0006998 ! nuclear envelope organization

[Term]
id: GO:0031469
name: polyhedral organelle
namespace: cellular_component
def: "An organelle found in bacteria consisting of a proteinaceous coat containing metabolic enzymes whose purpose is the sequestration or concentration of metabolites and which has the appearance of a polygonal granule by electron microscopy." [GOC:js, PMID:10498708, PMID:11844753, PMID:12923081]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle

[Term]
id: GO:0031470
name: carboxysome
namespace: cellular_component
def: "An organelle consisting of a proteinaceous coat and enzymes for the fixation of carbon dioxide including mechanisms for the concentration of carbonate to increase the efficiency of fixation under low-carbon dioxide conditions." [GOC:js, PMID:8157606, PMID:8491708]
subset: gosubset_prok
xref: Wikipedia:Carboxysome
is_a: GO:0031469 ! polyhedral organelle

[Term]
id: GO:0031471
name: ethanolamine degradation polyhedral organelle
namespace: cellular_component
def: "An organelle found in bacteria consisting of a proteinaceous coat containing enzymes for the degradation of ethanolamine whose purpose is the protection of the rest of the cell from the toxic acetaldehyde product of the enzyme ethanolamine ammonia lyase." [GOC:js, PMID:11844753]
subset: gosubset_prok
synonym: "ethanolamine metabolosome" RELATED []
is_a: GO:0031469 ! polyhedral organelle

[Term]
id: GO:0031472
name: propanediol degradation polyhedral organelle
namespace: cellular_component
def: "An organelle found in bacteria consisting of a proteinaceous coat containing enzymes for the degradation of 1,2-propanediol whose purpose is the protection of the rest of the cell from the toxic propionaldehyde product of the enzyme diol dehydratase." [GOC:js, PMID:10498708, PMID:11844753, PMID:12923081]
subset: gosubset_prok
is_a: GO:0031469 ! polyhedral organelle

[Term]
id: GO:0031473
name: myosin III binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a class III myosin; myosin III is monomeric and has an N terminal kinase domain." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
is_a: GO:0017022 ! myosin binding

[Term]
id: GO:0031474
name: myosin IV complex
namespace: cellular_component
def: "A myosin complex containing one or more class IV myosin heavy chains and associated light chains; myosin IV is relatively uncharacterized, but is predicted to have a single motor domain, one IQ motif and a tail with a Myosin Tail Homology (myTH4) domain homologous to that in the tails of myosins VII and XV." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031475
name: myosin V complex
namespace: cellular_component
def: "A myosin complex containing a dimer of class V myosin heavy chains and associated light chains; involved in intracellular transport. Myosin V is a dimeric molecule consisting of conserved motor domains followed by 6 IQ motifs which bind specific light chains and calmodulin. The tail domain is important for cellular localization and cargo binding and can be divided into an alpha-helical coiled coil region and a C-terminal globular region." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031476
name: myosin VI complex
namespace: cellular_component
def: "A myosin complex containing one or more class VI myosin heavy chains and associated light chains. Myosin VI has a single IQ motif in the neck and a tail region with a coiled coil domain followed by a unique globular domain; a unique insertion that enables myosin VI to move towards the pointed or minus end of actin filaments." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031477
name: myosin VII complex
namespace: cellular_component
def: "A myosin complex containing a dimer of class VII myosin heavy chains and associated light chains. Myosin VII (240 kDa) is predicted to be a dimeric molecule with 5 IQ motifs and a tail region with a short stretch of coiled coil followed by two myosin-tail homology (MyTH4) domains, two talin-binding (FERM) domains and an SH3-domain." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031478
name: myosin VIII complex
namespace: cellular_component
def: "A myosin complex containing a dimer of class VIII myosin heavy chains and associated light chains. Myosin VIII is predicted to be dimeric, and contain an unusual 100-190 residue N-terminal extension prior to their motor domains, 3-4 IQ motifs, a short region (~70 residues) of predicted alpha-helical coiled coil and a C-terminal domain." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031479
name: myosin IX complex
namespace: cellular_component
def: "A myosin complex containing a class IX myosin heavy chain and associated light chains. Myosin IX is monomeric with a motor domain containing an N-terminal extension and an insert in the actin binding interface, followed by four to six IQ motifs and a tail region that contains a zinc binding motif and a domain with homology to GTPase activating proteins (GAPs) of the Rho family of G-proteins." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031480
name: myosin X complex
namespace: cellular_component
def: "A myosin complex containing one or more class X myosin heavy chains and associated light chains." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031481
name: myosin XI complex
namespace: cellular_component
def: "A myosin complex containing a dimer of class XI myosin heavy chains and associated light chains. Myosin XI heavy chain sizes are similar in molecular structure to the class V myosins with 5 to 6 IQ motifs and tail regions with predicted coiled coil domains (forming dimeric molecules) and large C-terminal regions." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031482
name: myosin XII complex
namespace: cellular_component
def: "A myosin complex containing one or more class XII myosin heavy chains and associated light chains; myosin XII contains a large tail region with two MyTH4 domains and a short region of coiled coil." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031483
name: myosin XIII complex
namespace: cellular_component
def: "A myosin complex containing one or more class XIII myosin heavy chains and associated light chains." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031484
name: myosin XIV complex
namespace: cellular_component
def: "A myosin complex containing a class XIV myosin heavy chain and associated light chains; myosin XIV heavy chains are the simplest known, containing a motor domain, no classic IQ motif and variable length tails." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031485
name: myosin XV complex
namespace: cellular_component
def: "A myosin complex containing a class XV myosin heavy chain and associated light chains. Myosin XV is single headed, and has a large extension (1200aa) at the N-terminus of the motor domain, two IQ motifs and a tail with a similar domain structure to that of the tail of myosin VII." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031486
name: myosin XVI complex
namespace: cellular_component
def: "A myosin complex containing a class XVI myosin heavy chains and associated light chains; myosin XVI heavy chains contain ankyrin repeat." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, PMID:11294886]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031487
name: myosin XVII complex
namespace: cellular_component
def: "A myosin complex containing one or more class XVII myosin heavy chains and associated light chains." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031488
name: myosin XVIII complex
namespace: cellular_component
def: "A myosin complex containing a class XVIII myosin heavy chain and associated light chains; myosin XVIII heavy chains contain an N-terminal PDZ domain." [PMID:11294886]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031489
name: myosin V binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a class V myosin; myosin V is a dimeric molecule involved in intracellular transport." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
is_a: GO:0017022 ! myosin binding

[Term]
id: GO:0031490
name: chromatin DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with DNA that is assembled into chromatin." [GOC:mah]
is_a: GO:0003682 ! chromatin binding
is_a: GO:0043566 ! structure-specific DNA binding

[Term]
id: GO:0031491
name: nucleosome binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:mah]
is_a: GO:0003682 ! chromatin binding
is_a: GO:0032403 ! protein complex binding

[Term]
id: GO:0031492
name: nucleosomal DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the DNA portion of a nucleosome." [GOC:mah]
is_a: GO:0031490 ! chromatin DNA binding
is_a: GO:0031491 ! nucleosome binding

[Term]
id: GO:0031493
name: nucleosomal histone binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a histone that is assembled into a nucleosome." [GOC:mah]
is_a: GO:0031491 ! nucleosome binding
is_a: GO:0042393 ! histone binding

[Term]
id: GO:0031494
name: regulation of mating type switching
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mating type switching, the conversion of a single-cell organism from one mating type to another by the precise replacement of a DNA sequence at the expressed mating type locus with a copy of a sequence from a donor locus." [GOC:mah]
is_a: GO:0010453 ! regulation of cell fate commitment
is_a: GO:0051052 ! regulation of DNA metabolic process
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007533 ! mating type switching
relationship: regulates GO:0007533 ! mating type switching

[Term]
id: GO:0031495
name: negative regulation of mating type switching
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mating type switching." [GOC:mah]
synonym: "down regulation of mating type switching" EXACT []
synonym: "down-regulation of mating type switching" EXACT []
synonym: "downregulation of mating type switching" EXACT []
synonym: "inhibition of mating type switching" NARROW []
is_a: GO:0010454 ! negative regulation of cell fate commitment
is_a: GO:0031494 ! regulation of mating type switching
is_a: GO:0051053 ! negative regulation of DNA metabolic process
is_a: GO:2000242 ! negative regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007533 ! mating type switching
relationship: negatively_regulates GO:0007533 ! mating type switching

[Term]
id: GO:0031496
name: positive regulation of mating type switching
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mating type switching." [GOC:mah]
synonym: "activation of mating type switching" NARROW []
synonym: "stimulation of mating type switching" NARROW []
synonym: "up regulation of mating type switching" EXACT []
synonym: "up-regulation of mating type switching" EXACT []
synonym: "upregulation of mating type switching" EXACT []
is_a: GO:0010455 ! positive regulation of cell fate commitment
is_a: GO:0031494 ! regulation of mating type switching
is_a: GO:0051054 ! positive regulation of DNA metabolic process
is_a: GO:2000243 ! positive regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007533 ! mating type switching
relationship: positively_regulates GO:0007533 ! mating type switching

[Term]
id: GO:0031497
name: chromatin assembly
namespace: biological_process
def: "The assembly of DNA, histone proteins, other associated proteins, and sometimes RNA, into chromatin structure, beginning with the formation of the basic unit, the nucleosome, followed by organization of the nucleosomes into higher order structures, ultimately giving rise to a complex organization of specific domains within the nucleus." [http://www.infobiogen.fr/services/chromcancer/IntroItems/ChromatinEducEng.html, PMID:20404130]
synonym: "establishment of chromatin architecture" EXACT [GOC:mah]
is_a: GO:0006333 ! chromatin assembly or disassembly
is_a: GO:0065003 ! macromolecular complex assembly
relationship: part_of GO:0006323 ! DNA packaging

[Term]
id: GO:0031498
name: chromatin disassembly
namespace: biological_process
def: "The controlled breakdown of chromatin from a higher order structure into its simpler subcomponents, DNA, histones, other proteins, and sometimes RNA." [http://www.infobiogen.fr/services/chromcancer/IntroItems/ChromatinEducEng.html, PMID:20404130]
is_a: GO:0006333 ! chromatin assembly or disassembly
is_a: GO:0032984 ! macromolecular complex disassembly
is_a: GO:1902589 ! single-organism organelle organization

[Term]
id: GO:0031499
name: TRAMP complex
namespace: cellular_component
def: "A multiprotein complex having distributive polyadenylation activity of a variety of RNA substrates including hypomodified and incorrectly folded tRNAs, pre-snRNAs, pre-snoRNAs, incorrectly spliced or processed pre-mRNAs, cryptic unstable transcripts (CUTs), pre-rRNAs and rRNA fragments released as part of rRNA processing. In S. cerevisiae, the complex consists of either Pap2 (also known as Trf4) or Trf5, Air1 or Air2, and Mtr4, and is involved in RNA 3'-end processing and in RNA surveillance and quality control." [PMID:15173578, PMID:15828860, PMID:15935758, PMID:15935759, PMID:16373491, PMID:16374505, PMID:16431988, PMID:16973437, PMID:17410208, PMID:17652137]
synonym: "TRAMP4 complex" NARROW []
synonym: "TRAMP5 complex" NARROW []
synonym: "Trf4 complex" NARROW []
synonym: "Trf4 poly(A) polymerase complex" NARROW []
synonym: "Trf4p-Air2p-Mtr4p polyadenylation complex" NARROW []
xref: Wikipedia:TRAMP_complex
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0031500
name: Tea1 cell-end complex
namespace: cellular_component
def: "A high molecular weight complex characterized in S. pombe containing the cell-end anchoring protein Tea1. This complex is transported to the cell ends by microtubules and is involved in bipolar growth and the maintennce of normal cell polarity." [PMID:15936270]
is_a: GO:0005875 ! microtubule associated complex
is_a: GO:0044448 ! cell cortex part
relationship: part_of GO:0000133 ! polarisome

[Term]
id: GO:0031501
name: mannosyltransferase complex
namespace: cellular_component
def: "A complex that posseses mannosyltransferase activity." [GOC:mah]
subset: goslim_pir
is_a: GO:0044424 ! intracellular part
is_a: GO:1990234 ! transferase complex

[Term]
id: GO:0031502
name: dolichyl-phosphate-mannose-protein mannosyltransferase complex
namespace: cellular_component
def: "A complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity; usually includes members of the PMT1 and PMT2 protein subfamilies." [GOC:mah, GOC:pr, PMID:15948957]
comment: Note that GO:0004169 'dolichyl-phosphate-mannose-protein mannosyltransferase activity' (part of protein O-linked mannosylation) has never been observed in green plants. However, N- and C-mannosylation may occur in these species; see figure 1 in PMID:21558543.
synonym: "PMT family mannosyltransferase complex" RELATED []
synonym: "protein O-mannosyltransferase complex" EXACT []
is_a: GO:0031501 ! mannosyltransferase complex
is_a: GO:0044432 ! endoplasmic reticulum part
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane

[Term]
id: GO:0031503
name: protein complex localization
namespace: biological_process
def: "A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location." [GOC:mah]
subset: gosubset_prok
synonym: "establishment and maintenance of protein complex localization" EXACT []
synonym: "protein complex localisation" EXACT [GOC:mah]
is_a: GO:0008104 ! protein localization

[Term]
id: GO:0031504
name: peptidoglycan-based cell wall organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the peptidoglycan-based cell wall." [GOC:dph, GOC:jl, GOC:mah, GOC:mtg_sensu]
subset: gosubset_prok
synonym: "peptidoglycan-based cell wall organisation" EXACT [GOC:mah]
synonym: "peptidoglycan-based cell wall organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0071555 ! cell wall organization

[Term]
id: GO:0031505
name: fungal-type cell wall organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fungal-type cell wall." [GOC:dph, GOC:jl, GOC:mah, GOC:mtg_sensu]
synonym: "beta-glucan-containing cell wall organization and biogenesis" RELATED []
synonym: "chitin- and beta-glucan-containing cell wall organisation" NARROW []
synonym: "chitin- and beta-glucan-containing cell wall organization and biogenesis" NARROW []
synonym: "chitin-containing cell wall organization and biogenesis" RELATED []
synonym: "fungal-type cell wall organization and biogenesis" RELATED []
is_a: GO:0071555 ! cell wall organization
is_a: GO:0071852 ! fungal-type cell wall organization or biogenesis

[Term]
id: GO:0031506
name: cell wall glycoprotein biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cell wall glycoproteins, any cell wall protein that contains covalently bound sugar residues." [GOC:mah]
subset: gosubset_prok
synonym: "cell wall glycoprotein anabolism" EXACT []
synonym: "cell wall glycoprotein biosynthesis" EXACT []
synonym: "cell wall glycoprotein formation" EXACT []
synonym: "cell wall glycoprotein synthesis" EXACT []
is_a: GO:0009101 ! glycoprotein biosynthetic process
is_a: GO:0044038 ! cell wall macromolecule biosynthetic process

[Term]
id: GO:0031507
name: heterochromatin assembly
namespace: biological_process
def: "The assembly of chromatin into heterochromatin, a compact and highly condensed form that is often, but not always, transcriptionally silent." [GOC:mah]
synonym: "establishment of heterochromatin architecture" EXACT [GOC:mah]
synonym: "heterochromatin formation" EXACT []
is_a: GO:0006338 ! chromatin remodeling
is_a: GO:0031497 ! chromatin assembly
is_a: GO:0070828 ! heterochromatin organization

[Term]
id: GO:0031508
name: pericentric heterochromatin assembly
namespace: biological_process
def: "The assembly of chromatin into heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3." [GOC:mah, PMID:20206496, PMID:22729156]
synonym: "centric heterochromatin formation" RELATED []
synonym: "centromeric heterochromatin biosynthesis" EXACT []
synonym: "centromeric heterochromatin formation" EXACT []
is_a: GO:0031055 ! chromatin remodeling at centromere
is_a: GO:0031507 ! heterochromatin assembly
relationship: part_of GO:0034508 ! centromere complex assembly

[Term]
id: GO:0031509
name: telomeric heterochromatin assembly
namespace: biological_process
def: "The assembly of chromatin into heterochromatin at the telomere." [GOC:mah]
synonym: "telomeric heterochromatin formation" EXACT []
is_a: GO:0031507 ! heterochromatin assembly

[Term]
id: GO:0031510
name: SUMO activating enzyme complex
namespace: cellular_component
def: "A conserved heterodimeric complex with SUMO activating enzyme activity." [PMID:15601841]
synonym: "SAE" EXACT []
synonym: "SUMO E1 activator enzyme complex" EXACT []
is_a: GO:0044428 ! nuclear part
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0031511
name: Mis6-Sim4 complex
namespace: cellular_component
def: "A protein complex that forms part of the inner centromere, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. The complex contains about 12 proteins, of which two are known as Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human." [GOC:vw, PMID:12719471, PMID:15897182]
synonym: "Mis6 centromere subcomplex" NARROW []
synonym: "Mis6-Mal2-Sim4 centromere complex" EXACT [GOC:vw, PMID:21445296]
synonym: "Sim4 complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000939 ! condensed chromosome inner kinetochore

[Term]
id: GO:0031512
name: motile primary cilium
namespace: cellular_component
def: "A primary cilium which may contain a variable array of axonemal microtubules and also contains molecular motors. Motile primary cilia display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization." [GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998]
comment: Note that this term should not be confused with 'motile cilium ; GO:0031514': Motile primary cilia are distinct from motile cilia (GO:0031514) that are typically present on epithelial cells in multiple copies and move in a whip-like, as opposed to rotational, manner.
synonym: "motile primary cilia" EXACT [GOC:curators]
synonym: "nodal cilium" RELATED [GOC:curators]
is_a: GO:0072372 ! primary cilium

[Term]
id: GO:0031513
name: nonmotile primary cilium
namespace: cellular_component
def: "A primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules." [GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998]
synonym: "immotile primary cilium" EXACT [GOC:curators]
synonym: "nonmotile primary cilia" EXACT [GOC:curators]
synonym: "sensory cilium" EXACT [GOC:curators]
is_a: GO:0072372 ! primary cilium

[Term]
id: GO:0031514
name: motile cilium
namespace: cellular_component
alt_id: GO:0009434
def: "A cilium which has a variable arrangement of axonemal microtubules, contains molecular motors, and beats with a characteristic whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface. Motile cilia are typically found in multiple copies on epithelial cells that line the lumenal ducts of various tissues. Motile cilia may also function as sensory organelles." [GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998]
comment: Note that this term should not be confused with 'motile primary cilium ; GO:0031512'. Motile cilia are distinct from motile primary cilia (GO:0031512) that are typically present during embryogenesis in a single copy per cell, affect asymmetric body plan organization, and move in a rotational manner, as opposed to a whip-like, manner.
synonym: "microtubule-based flagellum" RELATED []
synonym: "motile cilia" EXACT [GOC:curators]
synonym: "motile secondary cilium" RELATED [GOC:curators]
is_a: GO:0005929 ! cilium

[Term]
id: GO:0031515
name: tRNA (m1A) methyltransferase complex
namespace: cellular_component
def: "A protein complex involved in the catalysis of the formation of the modified nucleotide 1-methyladenosine (m1A) in tRNA. In yeast, it is a heterotetramer of two subunits, Gcd10p and Gcd14p, while in bacteria and archaea it is a homotetramer." [PMID:10779558, PMID:14739239]
subset: gosubset_prok
is_a: GO:0043527 ! tRNA methyltransferase complex

[Term]
id: GO:0031516
name: far-red light photoreceptor activity
namespace: molecular_function
def: "The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 730nm. The response may involve a change in conformation." [GOC:nln]
is_a: GO:0009883 ! red or far-red light photoreceptor activity
relationship: part_of GO:0010018 ! far-red light signaling pathway

[Term]
id: GO:0031517
name: red light photoreceptor activity
namespace: molecular_function
def: "The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 660nm. The response may involve a change in conformation." [GOC:nln]
is_a: GO:0009883 ! red or far-red light photoreceptor activity
relationship: part_of GO:0010161 ! red light signaling pathway

[Term]
id: GO:0031518
name: CBF3 complex
namespace: cellular_component
def: "A multisubunit protein complex that binds to centromeric DNA and initiates kinetochore assembly. In yeast, this complex consists of four subunits, namely Ctf13p, Skp1p, Cep3p and Cbf2p." [PMID:13679521, PMID:9407032]
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000775 ! chromosome, centromeric region

[Term]
id: GO:0031519
name: PcG protein complex
namespace: cellular_component
def: "A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure." [PMID:9372908]
subset: goslim_pir
synonym: "Polycomb Group protein complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0031520
name: plasma membrane of cell tip
namespace: cellular_component
def: "The portion of the plasma membrane surrounding the cell tip." [GOC:mah]
is_a: GO:0098590 ! plasma membrane region
relationship: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0051286 ! cell tip

[Term]
id: GO:0031521
name: spitzenkorper
namespace: cellular_component
def: "Structure within the hyphal tip of filamentous fungi that acts as an organizing center for hyphal tip growth; may function to supply vesicles to the elongating tip and/or to organize cytoskeletal microfilaments." [PMID:15701784, PMID:15976451]
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0001411 ! hyphal tip
relationship: part_of GO:0012505 ! endomembrane system

[Term]
id: GO:0031522
name: cell envelope Sec protein transport complex
namespace: cellular_component
def: "A transmembrane protein complex involved in the translocation of proteins across the cytoplasmic membrane. In Gram-negative bacteria, Sec-translocated proteins are subsequently secreted via the type II, IV, or V secretion systems. Sec complex components include SecA, D, E, F, G, Y and YajC." [GOC:mtg_sensu, PMID:15223057]
comment: Note that this term represents the protein complex involved in transport of proteins across the cytoplasmic membrane. For proteins involved in bacterial Type II secretion across the outer membrane, consider annotating to 'type II protein secretion complex ; GO:0015628'. For proteins involved in Sec-complex dependent translocation into the eukaryotic endoplasmic reticulum, consider annotating to 'endoplasmic reticulum Sec complex ; GO:0031205'.
subset: gosubset_prok
synonym: "plasma membrane Sec complex" RELATED []
synonym: "Sec complex" BROAD []
synonym: "Sec secretion complex" NARROW []
synonym: "Sec translocation complex" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0031523
name: Myb complex
namespace: cellular_component
def: "A multisubunit complex consisting of Myb and other proteins that regulates site specific DNA replication, gene amplification and transcriptional repression." [PMID:12490953, PMID:15545624]
synonym: "Myeloblastosis proto-oncogene protein complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part

[Term]
id: GO:0031524
name: menthol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving menthol, the monoterpene 2-isopropyl-5-methylcyclohexanol." [GOC:mah]
subset: gosubset_prok
synonym: "menthol metabolism" EXACT []
is_a: GO:0016098 ! monoterpenoid metabolic process
is_a: GO:1902652 ! secondary alcohol metabolic process

[Term]
id: GO:0031525
name: menthol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of menthol, the monoterpene 2-isopropyl-5-methylcyclohexanol." [GOC:mah]
subset: gosubset_prok
synonym: "menthol anabolism" EXACT []
synonym: "menthol biosynthesis" EXACT []
synonym: "menthol formation" EXACT []
synonym: "menthol synthesis" EXACT []
is_a: GO:0016099 ! monoterpenoid biosynthetic process
is_a: GO:0031524 ! menthol metabolic process
is_a: GO:1902653 ! secondary alcohol biosynthetic process

[Term]
id: GO:0031526
name: brush border membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding the brush border." [GOC:mah]
is_a: GO:0031253 ! cell projection membrane
relationship: part_of GO:0005903 ! brush border

[Term]
id: GO:0031527
name: filopodium membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a filopodium." [GOC:mah]
is_a: GO:0031253 ! cell projection membrane
relationship: part_of GO:0030175 ! filopodium

[Term]
id: GO:0031528
name: microvillus membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a microvillus." [GOC:mah]
is_a: GO:0031253 ! cell projection membrane
relationship: part_of GO:0005902 ! microvillus

[Term]
id: GO:0031529
name: ruffle organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ruffle, a projection at the leading edge of a crawling cell." [GOC:mah, PMID:10036235]
synonym: "ruffle organisation" EXACT [GOC:mah]
synonym: "ruffle organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0030030 ! cell projection organization

[Term]
id: GO:0031530
name: gonadotropin-releasing hormone receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a receptor for gonadotropin-releasing hormone (GnRH), a peptide hormone that is synthesized and released by the hypothalamus and is responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary." [GOC:pr, PMID:15196882]
synonym: "GnRH receptor binding" EXACT []
synonym: "gonadotrophin-releasing hormone receptor binding" EXACT [GOC:dph]
is_a: GO:0051428 ! peptide hormone receptor binding

[Term]
id: GO:0031531
name: thyrotropin-releasing hormone receptor binding
namespace: molecular_function
alt_id: GO:0031888
def: "Interacting selectively and non-covalently with a receptor for thyrotropin-releasing hormone, a tripeptide hormone that is produced by the hypothalamus and stimulates the release of thyroid-stimulating hormone (TSH) and prolactin by the anterior pituitary." [PMID:8592728]
synonym: "thyrotropin releasing hormone receptor binding" EXACT []
synonym: "thyrotropin-releasing hormone receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein coupled receptor binding
is_a: GO:0051428 ! peptide hormone receptor binding

[Term]
id: GO:0031532
name: actin cytoskeleton reorganization
namespace: biological_process
alt_id: GO:0007012
def: "A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:ecd, GOC:mah]
synonym: "actin cytoskeleton remodeling" EXACT []
synonym: "actin cytoskeleton reorganisation" EXACT [GOC:curators]
is_a: GO:0030036 ! actin cytoskeleton organization

[Term]
id: GO:0031533
name: mRNA cap methyltransferase complex
namespace: cellular_component
def: "A protein complex that consists of an RNA 5' triphosphatase and a guanyl transferase (Cet1p and Ceg1p in S. cerevisiae; Pct1 and Ceg1 in S. pombe) and is involved in mRNA capping." [GOC:vw, PMID:10347220]
synonym: "mRNA (guanine-N7) methyltransferase complex" EXACT []
synonym: "mRNA capping enzyme complex" EXACT [GOC:vw]
is_a: GO:0034708 ! methyltransferase complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0031534
name: minus-end directed microtubule sliding
namespace: biological_process
def: "The movement of one microtubule along another microtubule, where the motion is directed towards the minus ends of the microtubules." [GOC:mah, GOC:vw]
is_a: GO:0051012 ! microtubule sliding

[Term]
id: GO:0031535
name: plus-end directed microtubule sliding
namespace: biological_process
def: "The movement of one microtubule along another microtubule, where the motion is directed towards the plus ends of the microtubules." [GOC:mah, GOC:vw]
is_a: GO:0051012 ! microtubule sliding

[Term]
id: GO:0031536
name: positive regulation of exit from mitosis
namespace: biological_process
def: "Any process that activates or increases the rate of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity)." [GOC:mah]
synonym: "activation of exit from mitosis" NARROW []
synonym: "stimulation of exit from mitosis" NARROW []
synonym: "up regulation of exit from mitosis" EXACT []
synonym: "up-regulation of exit from mitosis" EXACT []
synonym: "upregulation of exit from mitosis" EXACT []
is_a: GO:0007096 ! regulation of exit from mitosis
is_a: GO:0045840 ! positive regulation of mitotic nuclear division
is_a: GO:1901992 ! positive regulation of mitotic cell cycle phase transition
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010458 ! exit from mitosis
relationship: positively_regulates GO:0010458 ! exit from mitosis

[Term]
id: GO:0031537
name: regulation of anthocyanin metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chemical reactions and pathways involving anthocyanins." [GOC:mah]
synonym: "regulation of anthocyanin metabolism" EXACT []
is_a: GO:0080090 ! regulation of primary metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0046283 ! anthocyanin-containing compound metabolic process
relationship: regulates GO:0046283 ! anthocyanin-containing compound metabolic process

[Term]
id: GO:0031538
name: negative regulation of anthocyanin metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving anthocyanins." [GOC:mah]
synonym: "down regulation of anthocyanin metabolic process" EXACT []
synonym: "down-regulation of anthocyanin metabolic process" EXACT []
synonym: "downregulation of anthocyanin metabolic process" EXACT []
synonym: "inhibition of anthocyanin metabolic process" NARROW []
synonym: "negative regulation of anthocyanin metabolism" EXACT []
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0031537 ! regulation of anthocyanin metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0046283 ! anthocyanin-containing compound metabolic process
relationship: negatively_regulates GO:0046283 ! anthocyanin-containing compound metabolic process

[Term]
id: GO:0031539
name: positive regulation of anthocyanin metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chemical reactions and pathways involving anthocyanins." [GOC:mah]
synonym: "activation of anthocyanin metabolic process" NARROW []
synonym: "positive regulation of anthocyanin metabolism" EXACT []
synonym: "stimulation of anthocyanin metabolic process" NARROW []
synonym: "up regulation of anthocyanin metabolic process" EXACT []
synonym: "up-regulation of anthocyanin metabolic process" EXACT []
synonym: "upregulation of anthocyanin metabolic process" EXACT []
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0031537 ! regulation of anthocyanin metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0046283 ! anthocyanin-containing compound metabolic process
relationship: positively_regulates GO:0046283 ! anthocyanin-containing compound metabolic process

[Term]
id: GO:0031540
name: regulation of anthocyanin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of anthocyanins." [GOC:mah]
synonym: "regulation of anthocyanin anabolism" EXACT []
synonym: "regulation of anthocyanin biosynthesis" EXACT []
synonym: "regulation of anthocyanin formation" EXACT []
synonym: "regulation of anthocyanin synthesis" EXACT []
is_a: GO:0009962 ! regulation of flavonoid biosynthetic process
is_a: GO:0031537 ! regulation of anthocyanin metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009718 ! anthocyanin-containing compound biosynthetic process
relationship: regulates GO:0009718 ! anthocyanin-containing compound biosynthetic process

[Term]
id: GO:0031541
name: negative regulation of anthocyanin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of anthocyanins." [GOC:mah]
synonym: "down regulation of anthocyanin biosynthetic process" EXACT []
synonym: "down-regulation of anthocyanin biosynthetic process" EXACT []
synonym: "downregulation of anthocyanin biosynthetic process" EXACT []
synonym: "inhibition of anthocyanin biosynthetic process" NARROW []
synonym: "negative regulation of anthocyanin anabolism" EXACT []
synonym: "negative regulation of anthocyanin biosynthesis" EXACT []
synonym: "negative regulation of anthocyanin formation" EXACT []
synonym: "negative regulation of anthocyanin synthesis" EXACT []
is_a: GO:0009964 ! negative regulation of flavonoid biosynthetic process
is_a: GO:0031538 ! negative regulation of anthocyanin metabolic process
is_a: GO:0031540 ! regulation of anthocyanin biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009718 ! anthocyanin-containing compound biosynthetic process
relationship: negatively_regulates GO:0009718 ! anthocyanin-containing compound biosynthetic process

[Term]
id: GO:0031542
name: positive regulation of anthocyanin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of anthocyanins." [GOC:mah]
synonym: "activation of anthocyanin biosynthetic process" NARROW []
synonym: "positive regulation of anthocyanin anabolism" EXACT []
synonym: "positive regulation of anthocyanin biosynthesis" EXACT []
synonym: "positive regulation of anthocyanin formation" EXACT []
synonym: "positive regulation of anthocyanin synthesis" EXACT []
synonym: "stimulation of anthocyanin biosynthetic process" NARROW []
synonym: "up regulation of anthocyanin biosynthetic process" EXACT []
synonym: "up-regulation of anthocyanin biosynthetic process" EXACT []
synonym: "upregulation of anthocyanin biosynthetic process" EXACT []
is_a: GO:0009963 ! positive regulation of flavonoid biosynthetic process
is_a: GO:0031539 ! positive regulation of anthocyanin metabolic process
is_a: GO:0031540 ! regulation of anthocyanin biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009718 ! anthocyanin-containing compound biosynthetic process
relationship: positively_regulates GO:0009718 ! anthocyanin-containing compound biosynthetic process

[Term]
id: GO:0031543
name: peptidyl-proline dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl hydroxy-L-proline + succinate + CO2." [GOC:mah, GOC:vw, PMID:24550447, PMID:24550462]
synonym: "proline hydroxylase activity" BROAD [GOC:krc, GOC:pr]
synonym: "proline,2-oxoglutarate 4-dioxygenase activity" BROAD [GOC:krc, GOC:pr]
synonym: "prolyl 4-hydroxylase activity" BROAD [GOC:krc, GOC:pr]
synonym: "prolyl hydroxylase activity" BROAD [GOC:krc, GOC:pr]
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
relationship: part_of GO:0019511 ! peptidyl-proline hydroxylation

[Term]
id: GO:0031544
name: peptidyl-proline 3-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl trans-3-hydroxy-L-proline + succinate + CO2." [GOC:mah]
is_a: GO:0031543 ! peptidyl-proline dioxygenase activity

[Term]
id: GO:0031545
name: peptidyl-proline 4-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl trans-4-hydroxy-L-proline + succinate + CO2." [GOC:mah]
synonym: "HIF-type prolyl 4-hydroxylase" NARROW []
synonym: "prolyl 4-hydroxylase" BROAD []
is_a: GO:0031543 ! peptidyl-proline dioxygenase activity

[Term]
id: GO:0031546
name: brain-derived neurotrophic factor receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the brain-derived neurotrophic factor receptor." [GOC:mah]
synonym: "BDNF receptor binding" EXACT []
synonym: "brain-derived neurotrophic factor ligand" NARROW []
is_a: GO:0005165 ! neurotrophin receptor binding

[Term]
id: GO:0031547
name: brain-derived neurotrophic factor receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a brain-derived neurotrophic factor receptor binding to one of its physiological ligands." [GOC:mah]
synonym: "BDNF receptor signaling pathway" EXACT []
synonym: "BDNF signalling pathway" EXACT []
synonym: "brain-derived neurotrophic factor receptor signalling pathway" EXACT []
is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway

[Term]
id: GO:0031548
name: regulation of brain-derived neurotrophic factor receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of signaling via the brain-derived neurotrophic factor receptor signaling pathway." [GOC:mah]
synonym: "regulation of BDNF receptor signaling pathway" EXACT []
synonym: "regulation of BDNF receptor signalling pathway" EXACT []
synonym: "regulation of brain-derived neurotrophic factor receptor signalling pathway" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031547 ! brain-derived neurotrophic factor receptor signaling pathway
relationship: regulates GO:0031547 ! brain-derived neurotrophic factor receptor signaling pathway

[Term]
id: GO:0031549
name: negative regulation of brain-derived neurotrophic factor receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signaling via the brain-derived neurotrophic factor receptor signaling pathway." [GOC:mah]
synonym: "down regulation of brain-derived neurotrophic factor receptor signaling pathway" EXACT []
synonym: "down-regulation of brain-derived neurotrophic factor receptor signaling pathway" EXACT []
synonym: "downregulation of brain-derived neurotrophic factor receptor signaling pathway" EXACT []
synonym: "inhibition of brain-derived neurotrophic factor receptor signaling pathway" NARROW []
synonym: "negative regulation of BDNF receptor signaling pathway" EXACT []
synonym: "negative regulation of BDNF receptor signalling pathway" EXACT []
synonym: "negative regulation of brain-derived neurotrophic factor receptor signalling pathway" EXACT []
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0031548 ! regulation of brain-derived neurotrophic factor receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0031547 ! brain-derived neurotrophic factor receptor signaling pathway
relationship: negatively_regulates GO:0031547 ! brain-derived neurotrophic factor receptor signaling pathway

[Term]
id: GO:0031550
name: positive regulation of brain-derived neurotrophic factor receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of signaling via the brain-derived neurotrophic factor receptor signaling pathway." [GOC:mah]
synonym: "activation of brain-derived neurotrophic factor receptor signaling pathway" NARROW []
synonym: "positive regulation of BDNF receptor signaling pathway" EXACT []
synonym: "positive regulation of BDNF receptor signalling pathway" EXACT []
synonym: "positive regulation of brain-derived neurotrophic factor receptor signalling pathway" EXACT []
synonym: "stimulation of brain-derived neurotrophic factor receptor signaling pathway" NARROW []
synonym: "up regulation of brain-derived neurotrophic factor receptor signaling pathway" EXACT []
synonym: "up-regulation of brain-derived neurotrophic factor receptor signaling pathway" EXACT []
synonym: "upregulation of brain-derived neurotrophic factor receptor signaling pathway" EXACT []
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0031548 ! regulation of brain-derived neurotrophic factor receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0031547 ! brain-derived neurotrophic factor receptor signaling pathway
relationship: positively_regulates GO:0031547 ! brain-derived neurotrophic factor receptor signaling pathway

[Term]
id: GO:0031551
name: regulation of brain-derived neurotrophic factor-activated receptor activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of brain-derived neurotrophic factor-activated receptor activity." [GOC:mah]
synonym: "regulation of BDNF receptor activity" EXACT []
synonym: "regulation of brain-derived neurotrophic factor receptor activity" EXACT [GOC:bf, GOC:signaling]
is_a: GO:0010469 ! regulation of receptor activity
is_a: GO:0031548 ! regulation of brain-derived neurotrophic factor receptor signaling pathway
is_a: GO:0061097 ! regulation of protein tyrosine kinase activity
is_a: GO:0090287 ! regulation of cellular response to growth factor stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060175 ! brain-derived neurotrophic factor-activated receptor activity
relationship: regulates GO:0060175 ! brain-derived neurotrophic factor-activated receptor activity

[Term]
id: GO:0031552
name: negative regulation of brain-derived neurotrophic factor-activated receptor activity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of brain-derived neurotrophic factor-activated receptor activity." [GOC:mah]
synonym: "down regulation of brain-derived neurotrophic factor receptor activity" EXACT []
synonym: "down-regulation of brain-derived neurotrophic factor receptor activity" EXACT []
synonym: "downregulation of brain-derived neurotrophic factor receptor activity" EXACT []
synonym: "inhibition of brain-derived neurotrophic factor receptor activity" NARROW []
synonym: "negative regulation of BDNF receptor activity" EXACT []
synonym: "negative regulation of brain-derived neurotrophic factor receptor activity" EXACT [GOC:bf, GOC:signaling]
is_a: GO:0031549 ! negative regulation of brain-derived neurotrophic factor receptor signaling pathway
is_a: GO:0031551 ! regulation of brain-derived neurotrophic factor-activated receptor activity
is_a: GO:0061099 ! negative regulation of protein tyrosine kinase activity
is_a: GO:0090288 ! negative regulation of cellular response to growth factor stimulus
is_a: GO:2000272 ! negative regulation of receptor activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060175 ! brain-derived neurotrophic factor-activated receptor activity
relationship: negatively_regulates GO:0060175 ! brain-derived neurotrophic factor-activated receptor activity

[Term]
id: GO:0031553
name: positive regulation of brain-derived neurotrophic factor-activated receptor activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of brain-derived neurotrophic factor-activated receptor activity." [GOC:mah]
synonym: "activation of brain-derived neurotrophic factor receptor activity" NARROW []
synonym: "positive regulation of BDNF receptor activity" EXACT []
synonym: "positive regulation of brain-derived neurotrophic factor receptor activity" EXACT [GOC:bf, GOC:signaling]
synonym: "stimulation of brain-derived neurotrophic factor receptor activity" NARROW []
synonym: "up regulation of brain-derived neurotrophic factor receptor activity" EXACT []
synonym: "up-regulation of brain-derived neurotrophic factor receptor activity" EXACT []
synonym: "upregulation of brain-derived neurotrophic factor receptor activity" EXACT []
is_a: GO:0031550 ! positive regulation of brain-derived neurotrophic factor receptor signaling pathway
is_a: GO:0031551 ! regulation of brain-derived neurotrophic factor-activated receptor activity
is_a: GO:0061098 ! positive regulation of protein tyrosine kinase activity
is_a: GO:2000273 ! positive regulation of receptor activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060175 ! brain-derived neurotrophic factor-activated receptor activity
relationship: positively_regulates GO:0060175 ! brain-derived neurotrophic factor-activated receptor activity

[Term]
id: GO:0031554
name: regulation of DNA-templated transcription, termination
namespace: biological_process
def: "Any process that modulates the frequency, rate, extent, or location of DNA-templated transcription termination, the process in which transcription is completed; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA." [GOC:mlg, GOC:txnOH]
synonym: "regulation of DNA-dependent transcription, termination" EXACT [GOC:txnOH]
synonym: "regulation of termination of DNA-dependent transcription" EXACT [GOC:jh2]
synonym: "regulation of transcription termination, DNA-dependent" EXACT [GOC:jh2]
synonym: "transcription antiterminator activity" RELATED []
is_a: GO:0006355 ! regulation of transcription, DNA-templated
is_a: GO:0043244 ! regulation of protein complex disassembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006353 ! DNA-templated transcription, termination
relationship: regulates GO:0006353 ! DNA-templated transcription, termination

[Term]
id: GO:0031555
name: transcriptional attenuation
namespace: biological_process
def: "Regulation of transcription through variation in where transcription termination occurs." [GOC:dh, GOC:mlg, ISBN:0198542682]
xref: Wikipedia:Attenuator_(genetics)
is_a: GO:0031554 ! regulation of DNA-templated transcription, termination

[Term]
id: GO:0031556
name: transcriptional attenuation by ribosome
namespace: biological_process
def: "A type of transcriptional regulation at the level of early termination. This process can occur only in prokaryotes, where transcription of an operon into messenger RNA and translation of that mRNA into polypeptides occur simultaneously. The general principle is that alternative mRNA secondary structures occur under different physiological conditions such as available amount of a particular amino acid. One set of conditions favors early termination of transcription. In the classic example of the trp biosynthesis operon, translation of the gene for a short, trp-containing polypeptide called the trp operon leader peptide pauses either at a trp codon (if tryptophan is scarce) or the stop codon (if trp is readily available). In the former situation transcription continues, but in the latter a Rho-independent terminator forms and reduces, or attenuates, expression of the tryptophan biosynthesis genes. Although the polypeptides encoded by leader peptide genes appear not to be stable once their translation is complete, it is suggested by recent studies that their nascent polypeptide chains interact specifically with ribosomes, specific uncharged tRNAs, or other cellular components to inhibit release at the stop codon and improve the function of transcriptional attenuation as a regulatory switch." [GOC:dh, GOC:mlg, ISBN:0198542682]
synonym: "ribosome-mediated transcriptional attenuation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0031555 ! transcriptional attenuation

[Term]
id: GO:0031557
name: obsolete induction of programmed cell death in response to chemical stimulus
namespace: biological_process
def: "OBSOLETE. A process which directly activates any of the steps required for programmed cell death as a result of a chemical stimulus." [GOC:mah, GOC:mtg_apoptosis]
comment: This term was made obsolete because it is now superseded by better defined and more specific terms under the node of GO:0012501 programmed cell death.
synonym: "induction of programmed cell death in response to chemical stimulus" EXACT []
synonym: "induction of programmed cell death in response to chemical substance" EXACT []
is_obsolete: true

[Term]
id: GO:0031558
name: obsolete induction of apoptosis in response to chemical stimulus
namespace: biological_process
def: "OBSOLETE. Any process that directly activates any of the steps required for cell death by apoptosis as a result of a chemical stimulus." [GOC:mah, GOC:mtg_apoptosis]
comment: This term was made obsolete because it is now superseded by better defined and more specific terms under the node of GO:0006915 apoptotic process.
synonym: "induction of apoptosis in response to chemical stimulus" EXACT []
synonym: "induction of apoptosis in response to chemical substance" EXACT []
is_obsolete: true

[Term]
id: GO:0031559
name: oxidosqualene cyclase activity
namespace: molecular_function
def: "Catalysis of the cyclization of (S)-2,3-epoxysqualene to form a triterpene." [GOC:ct]
comment: Note that the phrase 'oxidosqualene cyclase' has been used to refer to enzymes that catalyze the reaction represented by 'lanosterol synthase activity ; GO:0000250'.
subset: gosubset_prok
subset: mf_needs_review
synonym: "2,3-oxidosqualene cyclase activity" EXACT [GOC:mah]
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0031560
name: cellular bud neck polarisome
namespace: cellular_component
def: "Protein complex that has a role in determining cell polarity, found at the neck of a fungal bud before and during cytokinesis." [PMID:9632790]
is_a: GO:0000133 ! polarisome
intersection_of: GO:0000133 ! polarisome
intersection_of: part_of GO:0005935 ! cellular bud neck
relationship: part_of GO:0005935 ! cellular bud neck

[Term]
id: GO:0031561
name: cellular bud tip polarisome
namespace: cellular_component
def: "Protein complex that has a role in determining cell polarity, found at the tip of a growing fungal bud." [PMID:9632790]
is_a: GO:0000133 ! polarisome
intersection_of: GO:0000133 ! polarisome
intersection_of: part_of GO:0005934 ! cellular bud tip
relationship: part_of GO:0005934 ! cellular bud tip

[Term]
id: GO:0031562
name: hyphal tip polarisome
namespace: cellular_component
def: "Protein complex that has a role in determining cell polarity, found at the tip of a growing fungal hypha." [PMID:15976451]
is_a: GO:0000133 ! polarisome
intersection_of: GO:0000133 ! polarisome
intersection_of: part_of GO:0001411 ! hyphal tip
relationship: part_of GO:0001411 ! hyphal tip

[Term]
id: GO:0031563
name: mating projection tip polarisome
namespace: cellular_component
def: "Protein complex that has a role in determining cell polarity, found at the tip of the mating projection in unicellular fungi exposed to mating pheromone." [PMID:14734532]
is_a: GO:0000133 ! polarisome
is_a: GO:0044463 ! cell projection part
intersection_of: GO:0000133 ! polarisome
intersection_of: part_of GO:0043332 ! mating projection tip
relationship: part_of GO:0043332 ! mating projection tip

[Term]
id: GO:0031564
name: transcription antitermination
namespace: biological_process
def: "Regulation of transcription by a mechanism that allows RNA polymerase to continue transcription beyond a termination site." [ISBN:0198577788, PMID:12456320]
synonym: "transcriptional readthrough" EXACT []
is_a: GO:0031555 ! transcriptional attenuation

[Term]
id: GO:0031565
name: obsolete cytokinesis checkpoint
namespace: biological_process
alt_id: GO:0000135
def: "OBSOLETE. A mitotic cell cycle checkpoint that detects a defect in cytokinesis and negatively regulates G2/M transition." [GOC:mtg_cell_cycle]
comment: The reason this term was made obsolete is that the two terms cytokinesis checkpoint (GO:0031565) and cytokinesis after mitosis (GO:0000078) were conflated in meaning.
synonym: "contractile ring checkpoint" EXACT []
synonym: "septin checkpoint" EXACT []
is_obsolete: true
consider: GO:0044878
consider: GO:0044879

[Term]
id: GO:0031566
name: actomyosin contractile ring maintenance
namespace: biological_process
def: "The cell cycle process in which the contractile ring is maintained in response to the cytokinesis checkpoint; that is when cytokinesis is delayed awaiting completion of nuclear division or the correct formation of cytokinetic structures. This process occurs in the context of cytokinesis that takes place as part of a cell cycle." [GOC:dph, GOC:mah, GOC:tb, GOC:vw]
synonym: "contractile ring maintenance involved in cell cycle cytokinesis" EXACT [GOC:mah, GOC:vw]
synonym: "cytokinesis, contractile ring maintenance, involved in cytokinesis during cell cycle" EXACT [GOC:dph, GOC:tb]
is_a: GO:0036212 ! contractile ring maintenance
is_a: GO:0043954 ! cellular component maintenance
relationship: part_of GO:0061640 ! cytoskeleton-dependent cytokinesis

[Term]
id: GO:0031567
name: mitotic cell size control checkpoint
namespace: biological_process
def: "The mitotic cell cycle checkpoint that delays or arrests cell cycle progression until cells have reached a critical size." [GOC:mtg_cell_cycle]
synonym: "mitotic cell cycle cell size control checkpoint" EXACT [GOC:mah]
is_a: GO:0007093 ! mitotic cell cycle checkpoint

[Term]
id: GO:0031568
name: G1 cell size control checkpoint
namespace: biological_process
def: "A mitotic cell cycle checkpoint that monitors cell size, and negatively regulates cell cycle progression between G1 and S phase until a critical size is reached." [GOC:mtg_cell_cycle]
synonym: "mitotic cell cycle G1/S transition size control checkpoint" EXACT []
synonym: "mitotic G1 cell size control checkpoint" EXACT []
is_a: GO:0031567 ! mitotic cell size control checkpoint
is_a: GO:0044819 ! mitotic G1/S transition checkpoint
intersection_of: GO:0031567 ! mitotic cell size control checkpoint
intersection_of: negatively_regulates GO:0000082 ! G1/S transition of mitotic cell cycle
relationship: negatively_regulates GO:0000082 ! G1/S transition of mitotic cell cycle

[Term]
id: GO:0031569
name: G2 cell size control checkpoint
namespace: biological_process
def: "A cell cycle checkpoint that monitors cell size, and negatively regulates cell cycle progression between G2 and M phase until a critical size is reached." [GOC:mtg_cell_cycle]
synonym: "G2/M transition size control checkpoint" EXACT []
synonym: "mitotic cell cycle G2/M transition size control checkpoint" EXACT [GOC:mah]
synonym: "mitotic G2 cell size control checkpoint" EXACT []
is_a: GO:0010972 ! negative regulation of G2/M transition of mitotic cell cycle
is_a: GO:0031567 ! mitotic cell size control checkpoint
intersection_of: GO:0031567 ! mitotic cell size control checkpoint
intersection_of: happens_during GO:0051319 ! G2 phase
relationship: happens_during GO:0051319 ! G2 phase

[Term]
id: GO:0031570
name: DNA integrity checkpoint
namespace: biological_process
def: "A cell cycle process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and progresses through signal transduction and ends with cell cycle effector processes." [GOC:mtg_cell_cycle]
is_a: GO:0000075 ! cell cycle checkpoint

[Term]
id: GO:0031571
name: mitotic G1 DNA damage checkpoint
namespace: biological_process
def: "A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G1/S transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle]
synonym: "mitotic cell cycle G1/S transition DNA damage checkpoint" EXACT []
is_a: GO:0044773 ! mitotic DNA damage checkpoint
is_a: GO:0044783 ! G1 DNA damage checkpoint
is_a: GO:0044819 ! mitotic G1/S transition checkpoint
intersection_of: GO:0044783 ! G1 DNA damage checkpoint
intersection_of: negatively_regulates GO:0000082 ! G1/S transition of mitotic cell cycle
relationship: negatively_regulates GO:0000082 ! G1/S transition of mitotic cell cycle

[Term]
id: GO:0031572
name: G2 DNA damage checkpoint
namespace: biological_process
def: "A cell cycle checkpoint that detects and negatively regulates progression from G2 to M phase in the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle]
comment: Note that this term should only be used as a grouping term for the mitotic and meiotic G2 DNA damage checkpoints, and should not be used for direct manual annotation. You should always be able to choose one of its child terms instead.
subset: gocheck_do_not_manually_annotate
synonym: "G2/M transition DNA damage checkpoint" EXACT []
is_a: GO:0000077 ! DNA damage checkpoint

[Term]
id: GO:0031573
name: intra-S DNA damage checkpoint
namespace: biological_process
def: "A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression." [GOC:vw]
synonym: "mitotic intra-S DNA damage checkpoint" EXACT []
synonym: "S-phase checkpoint" BROAD []
is_a: GO:0044773 ! mitotic DNA damage checkpoint

[Term]
id: GO:0031577
name: spindle checkpoint
namespace: biological_process
def: "A cell cycle checkpoint that originates from the mitotic or meiotic spindle." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct manual annotation as it should always be possible to choose either a mitotic or meiotic child term.
subset: gocheck_do_not_manually_annotate
xref: Wikipedia:Spindle_checkpoint
is_a: GO:0000075 ! cell cycle checkpoint

[Term]
id: GO:0031578
name: mitotic spindle orientation checkpoint
namespace: biological_process
def: "A cell cycle checkpoint that monitors and signals errors in the placement or orientation of the spindle in the cell. This delays the completion of anaphase until errors are corrected." [GOC:mtg_cell_cycle, PMID:14616062]
synonym: "mitotic cell cycle spindle orientation checkpoint" EXACT []
synonym: "SOC" EXACT []
synonym: "spindle position checkpoint" EXACT []
synonym: "SPOC" EXACT []
is_a: GO:0001100 ! negative regulation of exit from mitosis
is_a: GO:0071174 ! mitotic spindle checkpoint

[Term]
id: GO:0031579
name: membrane raft organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of membrane rafts, small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes." [GOC:dph, GOC:jl, GOC:mah]
synonym: "lipid raft organization" EXACT [GOC:mah]
synonym: "membrane raft organisation" EXACT [GOC:mah]
synonym: "membrane raft organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0044802 ! single-organism membrane organization

[Term]
id: GO:0031580
name: membrane raft distribution
namespace: biological_process
def: "The process that establishes the spatial arrangement of membrane rafts within a cellular membrane." [GOC:mah]
synonym: "lipid raft distribution" EXACT []
is_a: GO:0031579 ! membrane raft organization
is_a: GO:0051665 ! membrane raft localization
is_a: GO:1902580 ! single-organism cellular localization

[Term]
id: GO:0031581
name: hemidesmosome assembly
namespace: biological_process
def: "Assembly of hemidesmosomes, integrin-containing protein complexes that bind to laminin in the basal lamina. Hemidesmosomes form the contact between the basal surface of epithelial cells and the underlying basal lamina." [GOC:dgh, PMID:15983403]
xref: Reactome:REACT_102612 "Type I hemidesmosome assembly, Canis familiaris"
xref: Reactome:REACT_109746 "Type I hemidesmosome assembly, Rattus norvegicus"
xref: Reactome:REACT_112964 "Type I hemidesmosome assembly, Taeniopygia guttata"
xref: Reactome:REACT_113284 "Type I hemidesmosome assembly, Xenopus tropicalis"
xref: Reactome:REACT_20537 "Type I hemidesmosome assembly, Homo sapiens"
xref: Reactome:REACT_29687 "Type I hemidesmosome assembly, Sus scrofa"
xref: Reactome:REACT_30472 "Type I hemidesmosome assembly, Bos taurus"
xref: Reactome:REACT_78954 "Type I hemidesmosome assembly, Mus musculus"
xref: Reactome:REACT_81231 "Type I hemidesmosome assembly, Gallus gallus"
xref: Reactome:REACT_84486 "Type I hemidesmosome assembly, Danio rerio"
is_a: GO:0007044 ! cell-substrate junction assembly

[Term]
id: GO:0031582
name: replication fork arrest at rDNA repeats
namespace: biological_process
def: "A process that impedes the progress of the DNA replication fork at natural replication fork pausing sites within the eukaryotic rDNA repeat spacer." [GOC:mah, GOC:vw]
synonym: "replication fork arrest at ribosomal DNA repeats" EXACT []
synonym: "replication fork blocking at rDNA repeats" EXACT []
is_a: GO:0043007 ! maintenance of rDNA
is_a: GO:0043111 ! replication fork arrest

[Term]
id: GO:0031583
name: phospholipase D-activating G-protein coupled receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase D (PLD) and a subsequent increase in cellular levels of phosphatidic acid (PA)." [GOC:mah, GOC:signaling, PMID:11812783, PMID:15924269]
comment: This term is intended to cover steps in a GPCR signaling pathway both upstream and downstream of phospholipase C (PLC) activation.
synonym: "activation of phospholipase D activity by G-protein coupled receptor protein signaling pathway" RELATED [GOC:signaling]
synonym: "G-protein signalling, phospholipase D activating pathway" EXACT []
is_a: GO:0007186 ! G-protein coupled receptor signaling pathway
relationship: has_part GO:0031584 ! activation of phospholipase D activity

[Term]
id: GO:0031584
name: activation of phospholipase D activity
namespace: biological_process
def: "Any process that initiates the activity of inactive phospholipase D." [GOC:dph, GOC:mah, GOC:tb]
is_a: GO:0010518 ! positive regulation of phospholipase activity

[Term]
id: GO:0031585
name: regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel." [GOC:dph, GOC:mah, GOC:signaling]
synonym: "regulation of inositol-1,4,5-triphosphate receptor activity" EXACT [GOC:signaling]
synonym: "regulation of IP3 receptor activity" EXACT [GOC:dph]
is_a: GO:0010469 ! regulation of receptor activity
is_a: GO:0050848 ! regulation of calcium-mediated signaling
is_a: GO:0051279 ! regulation of release of sequestered calcium ion into cytosol
is_a: GO:1901019 ! regulation of calcium ion transmembrane transporter activity
is_a: GO:2001257 ! regulation of cation channel activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0005220 ! inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
relationship: regulates GO:0005220 ! inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

[Term]
id: GO:0031586
name: negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel." [GOC:dph, GOC:mah, GOC:signaling]
synonym: "down regulation of IP3 receptor activity" EXACT []
synonym: "down-regulation of IP3 receptor activity" EXACT []
synonym: "downregulation of IP3 receptor activity" EXACT []
synonym: "inhibition of IP3 receptor activity" NARROW []
synonym: "negative regulation of inositol 1,4,5-trisphosphate receptor activity" EXACT [GOC:signaling]
synonym: "negative regulation of IP3 receptor activity" RELATED [GOC:dph]
is_a: GO:0031585 ! regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
is_a: GO:0050849 ! negative regulation of calcium-mediated signaling
is_a: GO:0051280 ! negative regulation of release of sequestered calcium ion into cytosol
is_a: GO:1901020 ! negative regulation of calcium ion transmembrane transporter activity
is_a: GO:2000272 ! negative regulation of receptor activity
is_a: GO:2001258 ! negative regulation of cation channel activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0005220 ! inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
relationship: negatively_regulates GO:0005220 ! inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

[Term]
id: GO:0031587
name: positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel." [GOC:dph, GOC:mah, GOC:signaling]
synonym: "activation of IP3 receptor activity" NARROW []
synonym: "positive regulation of inositol-1,4,5-trisphosphate receptor activity" EXACT [GOC:bf]
synonym: "positive regulation of IP3 receptor activity" EXACT [GOC:dph]
synonym: "stimulation of IP3 receptor activity" NARROW []
synonym: "up regulation of IP3 receptor activity" EXACT []
synonym: "up-regulation of IP3 receptor activity" EXACT []
synonym: "upregulation of IP3 receptor activity" EXACT []
is_a: GO:0031585 ! regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
is_a: GO:0050850 ! positive regulation of calcium-mediated signaling
is_a: GO:0051281 ! positive regulation of release of sequestered calcium ion into cytosol
is_a: GO:1901021 ! positive regulation of calcium ion transmembrane transporter activity
is_a: GO:2000273 ! positive regulation of receptor activity
is_a: GO:2001259 ! positive regulation of cation channel activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0005220 ! inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
relationship: positively_regulates GO:0005220 ! inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

[Term]
id: GO:0031588
name: nucleotide-activated protein kinase complex
namespace: cellular_component
def: "A protein complex that possesses nucleotide-dependent protein kinase activity. The nucleotide can be AMP (in S. pombe and human) or ADP (in S. cerevisiae)." [GOC:bhm, GOC:mah, GOC:vw]
synonym: "5'-AMP-activated protein kinase complex" NARROW []
synonym: "ADP-activated protein kinase complex" NARROW []
synonym: "AMP-activated protein kinase complex" NARROW []
synonym: "AMPK complex" RELATED []
synonym: "Snf1 kinase complex" NARROW []
synonym: "Snf1 serine/threonine protein kinase complex" NARROW []
synonym: "SNF1/AMPK protein kinase complex" NARROW []
is_a: GO:0044424 ! intracellular part
is_a: GO:1902911 ! protein kinase complex

[Term]
id: GO:0031589
name: cell-substrate adhesion
namespace: biological_process
def: "The attachment of a cell to the underlying substrate via adhesion molecules." [GOC:mah, GOC:pf]
subset: gosubset_prok
is_a: GO:0007155 ! cell adhesion

[Term]
id: GO:0031590
name: wybutosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving wybutosine, 3H-imidazo[1,2-alpha]purine-7-butanoic acid, 4,9-dihydro- alpha-[(methoxycarbonyl)amino]- 4,6-dimethyl-9-oxo- 3-beta-D-ribofuranosyl methyl ester, a modified nucleoside found in some tRNA molecules." [GOC:mah, RNAmods:037]
synonym: "wybutosine metabolism" EXACT []
synonym: "yW metabolic process" EXACT []
synonym: "yW metabolism" EXACT []
is_a: GO:1901564 ! organonitrogen compound metabolic process
is_a: GO:1901657 ! glycosyl compound metabolic process

[Term]
id: GO:0031591
name: wybutosine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of wybutosine, 3H-imidazo[1,2-alpha]purine-7-butanoic acid, 4,9-dihydro- alpha-[(methoxycarbonyl)amino]- 4,6-dimethyl-9-oxo- 3-beta-D-ribofuranosyl methyl ester, a modified nucleoside found in some tRNA molecules." [GOC:hjd, GOC:mah, RNAmods:037]
comment: Note that wybutosine is a hypermodified G-residue, formerly called the Y-base, and its derivatives are exclusively found at position 37 (anticodon loop) of tRNAPhe.
synonym: "yW biosynthesis" EXACT []
synonym: "yW biosynthetic process" EXACT []
is_a: GO:0006400 ! tRNA modification
is_a: GO:0031590 ! wybutosine metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process
is_a: GO:1901659 ! glycosyl compound biosynthetic process

[Term]
id: GO:0031592
name: centrosomal corona
namespace: cellular_component
def: "An amorphous structure surrounding the core of the centrosome, from which microtubules are nucleated; contains gamma-tubulin." [GOC:kp, GOC:mah]
comment: Note that the centrosomal corona has been observed in Dictyostelium, and is the functional equivalent of pericentriolar material.
is_a: GO:0044450 ! microtubule organizing center part
relationship: part_of GO:0005813 ! centrosome

[Term]
id: GO:0031593
name: polyubiquitin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a polymer of ubiqutin." [GOC:mah]
synonym: "multiubiquitin binding" RELATED []
is_a: GO:0043130 ! ubiquitin binding

[Term]
id: GO:0031594
name: neuromuscular junction
namespace: cellular_component
def: "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln]
comment: In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting skeletal muscle fibers - all of which are  cholinergic and excitatory.  Both inhibitory and excitatory neuromuscular junctions exist in invertebrates, utilizing a range of neurotransmitters including glutamate, GABA and 5-HT.
synonym: "motor endplate" RELATED [NIF_Subcellular:nlx_subcell_20090512]
synonym: "NMJ" RELATED [GOC:ha]
xref: NIF_Subcellular:sao1124888485
xref: Wikipedia:Neuromuscular_junction
is_a: GO:0045202 ! synapse

[Term]
id: GO:0031595
name: nuclear proteasome complex
namespace: cellular_component
def: "A proteasome found in the nucleus of a cell." [GOC:mah]
is_a: GO:0000502 ! proteasome complex
is_a: GO:0044428 ! nuclear part
intersection_of: GO:0000502 ! proteasome complex
intersection_of: part_of GO:0005634 ! nucleus
relationship: part_of GO:0005634 ! nucleus
relationship: part_of GO:0031981 ! nuclear lumen

[Term]
id: GO:0031596
name: obsolete ER proteasome complex
namespace: cellular_component
def: "OBSOLETE. A proteasome found in the endoplasmic reticulum of a cell." [GOC:mah]
comment: This term was made obsolete because there is no evidence in the literature of its existence.
is_obsolete: true

[Term]
id: GO:0031597
name: cytosolic proteasome complex
namespace: cellular_component
def: "A proteasome complex found in the cytosol of a cell." [GOC:mah, GOC:mtg_sensu]
is_a: GO:0000502 ! proteasome complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0031598
name: nuclear proteasome regulatory particle
namespace: cellular_component
def: "The regulatory subcomplex of a proteasome located in the nucleus of a cell." [GOC:mah]
is_a: GO:0005838 ! proteasome regulatory particle
is_a: GO:0044428 ! nuclear part
intersection_of: GO:0005838 ! proteasome regulatory particle
intersection_of: part_of GO:0005634 ! nucleus
relationship: part_of GO:0005634 ! nucleus
relationship: part_of GO:0031595 ! nuclear proteasome complex

[Term]
id: GO:0031599
name: obsolete ER proteasome regulatory particle
namespace: cellular_component
def: "OBSOLETE. The regulatory subcomplex of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah]
comment: This term was made obsolete because there is no evidence in the literature of its existence.
is_obsolete: true

[Term]
id: GO:0031600
name: cytosolic proteasome regulatory particle
namespace: cellular_component
def: "A multisubunit complex located in the cytosol of a cell, which caps one or both ends of the proteasome core complex. This complex recognizes, unfolds ubiquitinated proteins and translocates them to the proteasome core complex." [GOC:mah, GOC:mtg_sensu]
is_a: GO:0005838 ! proteasome regulatory particle
is_a: GO:0044445 ! cytosolic part
relationship: part_of GO:0031597 ! cytosolic proteasome complex

[Term]
id: GO:0031601
name: nuclear proteasome core complex
namespace: cellular_component
def: "The core complex of a proteasome located in the nucleus of a cell." [GOC:mah]
is_a: GO:0005839 ! proteasome core complex
is_a: GO:0044428 ! nuclear part
intersection_of: GO:0005839 ! proteasome core complex
intersection_of: part_of GO:0005634 ! nucleus
relationship: part_of GO:0005634 ! nucleus
relationship: part_of GO:0031595 ! nuclear proteasome complex

[Term]
id: GO:0031602
name: obsolete ER proteasome core complex
namespace: cellular_component
def: "OBSOLETE. The core complex of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah]
comment: This term was made obsolete because there is no evidence in the literature of its existence.
is_obsolete: true

[Term]
id: GO:0031603
name: cytosolic proteasome core complex
namespace: cellular_component
def: "The core complex of a proteasome located in the cytosol of a cell." [GOC:mah, GOC:mtg_sensu]
is_a: GO:0005839 ! proteasome core complex
is_a: GO:0044445 ! cytosolic part
relationship: part_of GO:0031597 ! cytosolic proteasome complex

[Term]
id: GO:0031604
name: nuclear proteasome core complex, alpha-subunit complex
namespace: cellular_component
def: "The subunits forming the outer ring of the core complex of a proteasome located in the nucleus of a cell." [GOC:mah]
is_a: GO:0019773 ! proteasome core complex, alpha-subunit complex
is_a: GO:0044428 ! nuclear part
intersection_of: GO:0019773 ! proteasome core complex, alpha-subunit complex
intersection_of: part_of GO:0005634 ! nucleus
relationship: part_of GO:0005634 ! nucleus
relationship: part_of GO:0031601 ! nuclear proteasome core complex

[Term]
id: GO:0031605
name: obsolete ER proteasome core complex, alpha-subunit complex
namespace: cellular_component
def: "OBSOLETE. The subunits forming the outer ring of the core complex of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah]
comment: This term was made obsolete because there is no evidence in the literature of its existence.
is_obsolete: true

[Term]
id: GO:0031606
name: cytosolic proteasome core complex, alpha-subunit complex
namespace: cellular_component
def: "The proteasome core subcomplex that constitutes the two outer rings of the cytosolic proteasome core complex." [GOC:mah, GOC:mtg_sensu]
is_a: GO:0019773 ! proteasome core complex, alpha-subunit complex
is_a: GO:0044445 ! cytosolic part
relationship: part_of GO:0031603 ! cytosolic proteasome core complex

[Term]
id: GO:0031607
name: nuclear proteasome core complex, beta-subunit complex
namespace: cellular_component
def: "The subunits forming the inner ring of the core complex of a proteasome located in the nucleus of a cell." [GOC:mah]
is_a: GO:0019774 ! proteasome core complex, beta-subunit complex
is_a: GO:0044428 ! nuclear part
intersection_of: GO:0019774 ! proteasome core complex, beta-subunit complex
intersection_of: part_of GO:0005634 ! nucleus
relationship: part_of GO:0005634 ! nucleus
relationship: part_of GO:0031601 ! nuclear proteasome core complex

[Term]
id: GO:0031608
name: obsolete ER proteasome core complex, beta-subunit complex
namespace: cellular_component
def: "OBSOLETE. The subunits forming the inner ring of the core complex of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah]
comment: This term was made obsolete because there is no evidence in the literature of its existence.
is_obsolete: true

[Term]
id: GO:0031609
name: cytosolic proteasome core complex, beta-subunit complex
namespace: cellular_component
def: "The proteasome core subcomplex that constitutes the two inner rings of the cytosolic proteasome core complex." [GOC:mah, GOC:mtg_sensu]
is_a: GO:0019774 ! proteasome core complex, beta-subunit complex
is_a: GO:0044445 ! cytosolic part
relationship: part_of GO:0031603 ! cytosolic proteasome core complex

[Term]
id: GO:0031610
name: nuclear proteasome regulatory particle, base subcomplex
namespace: cellular_component
def: "The subunits of the regulatory particle that directly associate with the core complex of a proteasome located in the nucleus of a cell." [GOC:mah]
is_a: GO:0008540 ! proteasome regulatory particle, base subcomplex
is_a: GO:0044428 ! nuclear part
intersection_of: GO:0008540 ! proteasome regulatory particle, base subcomplex
intersection_of: part_of GO:0005634 ! nucleus
relationship: part_of GO:0005634 ! nucleus
relationship: part_of GO:0031598 ! nuclear proteasome regulatory particle

[Term]
id: GO:0031611
name: obsolete ER proteasome regulatory particle, base subcomplex
namespace: cellular_component
def: "OBSOLETE. The subunits of the regulatory particle that directly associate with the core complex of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah]
comment: This term was made obsolete because there is no evidence in the literature of its existence.
is_obsolete: true

[Term]
id: GO:0031612
name: cytosolic proteasome regulatory particle, base subcomplex
namespace: cellular_component
def: "The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex located in the cytosol of the cell." [GOC:mah, GOC:mtg_sensu]
is_a: GO:0008540 ! proteasome regulatory particle, base subcomplex
is_a: GO:0044445 ! cytosolic part
relationship: part_of GO:0031600 ! cytosolic proteasome regulatory particle

[Term]
id: GO:0031613
name: nuclear proteasome regulatory particle, lid subcomplex
namespace: cellular_component
def: "The subunits that form the peripheral lid of the regulatory particle of a proteasome located in the nucleus of a cell." [GOC:mah]
is_a: GO:0008541 ! proteasome regulatory particle, lid subcomplex
is_a: GO:0044428 ! nuclear part
intersection_of: GO:0008541 ! proteasome regulatory particle, lid subcomplex
intersection_of: part_of GO:0005634 ! nucleus
relationship: part_of GO:0005634 ! nucleus
relationship: part_of GO:0031598 ! nuclear proteasome regulatory particle

[Term]
id: GO:0031614
name: obsolete ER proteasome regulatory particle, lid subcomplex
namespace: cellular_component
def: "OBSOLETE. The subunits that form the peripheral lid of the regulatory particle of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah]
comment: This term was made obsolete because there is no evidence in the literature of its existence.
is_obsolete: true

[Term]
id: GO:0031615
name: cytosolic proteasome regulatory particle, lid subcomplex
namespace: cellular_component
def: "The subcomplex of the cytosolic proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex." [GOC:mah, GOC:mtg_sensu]
is_a: GO:0008541 ! proteasome regulatory particle, lid subcomplex
is_a: GO:0044445 ! cytosolic part
relationship: part_of GO:0031600 ! cytosolic proteasome regulatory particle

[Term]
id: GO:0031616
name: spindle pole centrosome
namespace: cellular_component
def: "A centrosome from which one pole of a mitotic or meiotic spindle is organized." [GOC:mah]
is_a: GO:0005813 ! centrosome
intersection_of: GO:0005813 ! centrosome
intersection_of: part_of GO:0000922 ! spindle pole
relationship: part_of GO:0000922 ! spindle pole

[Term]
id: GO:0031617
name: NMS complex
namespace: cellular_component
def: "A supercomplex formed by the association of two subcomplexes (known as MIND and Ndc80 in Schizosaccharomyces) with additional proteins at the kinetochores of condensed nuclear chromosomes." [PMID:16079914]
synonym: "KMN kinetochore network" EXACT []
synonym: "KNL-1-Mis12-Ndc80" EXACT []
synonym: "Ndc80-MIND-Spc7 complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000776 ! kinetochore

[Term]
id: GO:0031618
name: nuclear pericentric heterochromatin
namespace: cellular_component
alt_id: GO:0002137
def: "Nuclear heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3." [GOC:mah, PMID:20206496, PMID:22729156, PMID:9413993]
synonym: "nuclear centric heterochromatin" EXACT []
synonym: "nuclear cluster" NARROW []
is_a: GO:0005720 ! nuclear heterochromatin
is_a: GO:0005721 ! pericentric heterochromatin
intersection_of: GO:0005721 ! pericentric heterochromatin
intersection_of: part_of GO:0005634 ! nucleus
relationship: part_of GO:0005634 ! nucleus

[Term]
id: GO:0031619
name: homologous chromosome orientation involved in meiotic metaphase I plate congression
namespace: biological_process
def: "The cell cycle process in which the sister centromeres of one chromosome attach to microtubules that emanate from the same spindle pole, which ensures that homologous maternal and paternal chromosomes are pulled in opposite directions at anaphase of meiosis I." [PMID:15062096]
synonym: "homologous chromosome orientation during meiosis" RELATED [GOC:dph, GOC:tb]
synonym: "homologous chromosome orientation during meiosis I" RELATED []
is_a: GO:0051455 ! attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation
relationship: part_of GO:0043060 ! meiotic metaphase I plate congression

[Term]
id: GO:0031620
name: regulation of fever generation
namespace: biological_process
def: "Any process that modulates the rate or extent of fever generation." [GOC:add, GOC:dph, GOC:tb]
synonym: "regulation of pyrexia" EXACT []
is_a: GO:0002673 ! regulation of acute inflammatory response
is_a: GO:0031650 ! regulation of heat generation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001660 ! fever generation
relationship: regulates GO:0001660 ! fever generation

[Term]
id: GO:0031621
name: negative regulation of fever generation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate or extent of fever generation." [GOC:add, GOC:dph, GOC:tb]
synonym: "down regulation of fever" EXACT []
synonym: "down-regulation of fever" EXACT []
synonym: "downregulation of fever" EXACT []
synonym: "inhibition of fever" NARROW []
synonym: "negative regulation of pyrexia" EXACT []
is_a: GO:0002674 ! negative regulation of acute inflammatory response
is_a: GO:0031620 ! regulation of fever generation
is_a: GO:0031651 ! negative regulation of heat generation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001660 ! fever generation
relationship: negatively_regulates GO:0001660 ! fever generation

[Term]
id: GO:0031622
name: positive regulation of fever generation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of fever generation." [GOC:add]
synonym: "activation of fever" NARROW []
synonym: "positive regulation of pyrexia" EXACT []
synonym: "stimulation of fever" NARROW []
synonym: "up regulation of fever" EXACT []
synonym: "up-regulation of fever" EXACT []
synonym: "upregulation of fever" EXACT []
is_a: GO:0002675 ! positive regulation of acute inflammatory response
is_a: GO:0031620 ! regulation of fever generation
is_a: GO:0031652 ! positive regulation of heat generation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001660 ! fever generation
relationship: positively_regulates GO:0001660 ! fever generation

[Term]
id: GO:0031623
name: receptor internalization
namespace: biological_process
def: "A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane." [GOC:bf, GOC:mah, GOC:signaling, PMID:15006537, PMID:19643732]
is_a: GO:0006898 ! receptor-mediated endocytosis
is_a: GO:0043112 ! receptor metabolic process
is_a: GO:0044710 ! single-organism metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0044765 ! single-organism transport

[Term]
id: GO:0031624
name: ubiquitin conjugating enzyme binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a ubiquitin conjugating enzyme, any of the E2 proteins." [GOC:vp]
is_a: GO:0044390 ! ubiquitin-like protein conjugating enzyme binding

[Term]
id: GO:0031625
name: ubiquitin protein ligase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]
synonym: "ubiquitin ligase binding" EXACT []
is_a: GO:0044389 ! ubiquitin-like protein ligase binding

[Term]
id: GO:0031626
name: beta-endorphin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with beta-endorphin, a peptide generated by the cleavage of pro-opiomelanocortin." [GOC:nln, PMID:6267560]
is_a: GO:0042165 ! neurotransmitter binding
is_a: GO:0042277 ! peptide binding

[Term]
id: GO:0031627
name: telomeric loop formation
namespace: biological_process
def: "The process in which linear telomeric DNA is remodeled into duplex loops, by the invasion of a 3' single-stranded overhang into the duplex region." [GOC:vw, PMID:10338214]
synonym: "T loop biosynthesis" EXACT []
synonym: "T loop formation" EXACT []
synonym: "t-loop biosynthesis" EXACT []
synonym: "t-loop formation" EXACT []
is_a: GO:0000723 ! telomere maintenance

[Term]
id: GO:0031628
name: opioid receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an opioid receptor." [GOC:nln]
is_a: GO:0001664 ! G-protein coupled receptor binding

[Term]
id: GO:0031629
name: synaptic vesicle fusion to presynaptic active zone membrane
namespace: biological_process
def: "Fusion of the membrane of a synaptic vesicle with the presynaptic active zone membrane, thereby releasing its cargo neurotransmitters into the synaptic cleft." [ISBN:0071120009]
subset: goslim_synapse
synonym: "synaptic vesicle fusion" BROAD []
synonym: "synaptic vesicle fusion to pre-synaptic membrane" EXACT []
synonym: "synaptic vesicle fusion to presynaptic membrane" EXACT []
is_a: GO:0099500 ! vesicle fusion to plasma membrane
is_a: GO:0099531 ! presynaptic process involved in synaptic transmission
relationship: part_of GO:0016079 ! synaptic vesicle exocytosis

[Term]
id: GO:0031630
name: regulation of synaptic vesicle fusion to presynaptic membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane." [GOC:mah]
synonym: "regulation of synaptic vesicle fusion to pre-synaptic membrane" EXACT []
is_a: GO:0031338 ! regulation of vesicle fusion
is_a: GO:2000300 ! regulation of synaptic vesicle exocytosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031629 ! synaptic vesicle fusion to presynaptic active zone membrane
relationship: regulates GO:0031629 ! synaptic vesicle fusion to presynaptic active zone membrane

[Term]
id: GO:0031631
name: negative regulation of synaptic vesicle fusion to presynaptic membrane
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane." [GOC:mah]
synonym: "down regulation of synaptic vesicle fusion to presynaptic membrane" EXACT []
synonym: "down-regulation of synaptic vesicle fusion to presynaptic membrane" EXACT []
synonym: "downregulation of synaptic vesicle fusion to presynaptic membrane" EXACT []
synonym: "inhibition of synaptic vesicle fusion to presynaptic membrane" NARROW []
synonym: "negative regulation of synaptic vesicle fusion to pre-synaptic membrane" EXACT []
is_a: GO:0031339 ! negative regulation of vesicle fusion
is_a: GO:0031630 ! regulation of synaptic vesicle fusion to presynaptic membrane
is_a: GO:2000301 ! negative regulation of synaptic vesicle exocytosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0031629 ! synaptic vesicle fusion to presynaptic active zone membrane
relationship: negatively_regulates GO:0031629 ! synaptic vesicle fusion to presynaptic active zone membrane

[Term]
id: GO:0031632
name: positive regulation of synaptic vesicle fusion to presynaptic membrane
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane." [GOC:mah]
synonym: "activation of synaptic vesicle fusion to presynaptic membrane" NARROW []
synonym: "positive regulation of synaptic vesicle fusion to pre-synaptic membrane" EXACT []
synonym: "stimulation of synaptic vesicle fusion to presynaptic membrane" NARROW []
synonym: "up regulation of synaptic vesicle fusion to presynaptic membrane" EXACT []
synonym: "up-regulation of synaptic vesicle fusion to presynaptic membrane" EXACT []
synonym: "upregulation of synaptic vesicle fusion to presynaptic membrane" EXACT []
is_a: GO:0031340 ! positive regulation of vesicle fusion
is_a: GO:0031630 ! regulation of synaptic vesicle fusion to presynaptic membrane
is_a: GO:2000302 ! positive regulation of synaptic vesicle exocytosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0031629 ! synaptic vesicle fusion to presynaptic active zone membrane
relationship: positively_regulates GO:0031629 ! synaptic vesicle fusion to presynaptic active zone membrane

[Term]
id: GO:0031633
name: xanthophore
namespace: cellular_component
def: "A chromatophore containing yellow pigment." [ISBN:0395825172]
comment: Note that this term refers to a subcellular structure, and should not be confused with the specialized cells known as xanthophores, which produce yellow pigment and are found in fish and amphibian skin. Note that several terms in the biological process ontology ('xanthophore differentiation ; GO:0050936' and its children) refer to xanthophores in the sense of pigment-producing cells.
is_a: GO:0042716 ! plasma membrane-derived chromatophore

[Term]
id: GO:0031634
name: replication fork barrier binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with replication fork barriers, sites that inhibit the progress of replication forks." [GOC:mah]
is_a: GO:1990837 ! sequence-specific double-stranded DNA binding

[Term]
id: GO:0031635
name: adenylate cyclase-inhibiting opioid receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of an opioid receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb]
synonym: "inhibition of adenylate cyclase activity by opioid receptor signaling pathway" RELATED [GOC:signaling]
synonym: "inhibition of adenylate cyclase activity by opioid receptor signalling pathway" RELATED [GOC:mah]
synonym: "opioid receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:dph, GOC:tb]
is_a: GO:0007193 ! adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
is_a: GO:0038003 ! opioid receptor signaling pathway

[Term]
id: GO:0031637
name: regulation of neuronal synaptic plasticity in response to neurotrophin
namespace: biological_process
def: "The process in which a neurotrophic factor induces neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:mah, PMID:8703078]
synonym: "neurotrophin-induced neuronal synaptic plasticity" EXACT []
is_a: GO:0048168 ! regulation of neuronal synaptic plasticity

[Term]
id: GO:0031638
name: zymogen activation
namespace: biological_process
def: "The proteolytic processing of an inactive enzyme to an active form." [GOC:hjd]
subset: goslim_chembl
synonym: "zymogen activation by proteolytic cleavage" EXACT []
is_a: GO:0016485 ! protein processing

[Term]
id: GO:0031639
name: plasminogen activation
namespace: biological_process
def: "The process in which inactive plasminogen is processed to active plasmin. This process includes cleavage at an internal Arg-Val site to form an N-terminal A-chain and C-terminal B-chain held together by a disulfide bond, and can include further proteolytic cleavage events to remove the preactivation peptide." [PMID:9548733]
subset: goslim_chembl
synonym: "cleavage of plasminogen to plasmin" EXACT []
is_a: GO:0031638 ! zymogen activation

[Term]
id: GO:0031640
name: killing of cells of other organism
namespace: biological_process
alt_id: GO:0001908
def: "Any process in an organism that results in the killing of cells of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions." [GOC:add]
subset: goslim_pir
subset: gosubset_prok
synonym: "killing of cells of another organism" EXACT [GOC:bf]
synonym: "killing of cells of another, non-host, organism" NARROW []
is_a: GO:0001906 ! cell killing
is_a: GO:0044364 ! disruption of cells of other organism

[Term]
id: GO:0031641
name: regulation of myelination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons." [GOC:mah]
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:0051960 ! regulation of nervous system development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042552 ! myelination
relationship: regulates GO:0042552 ! myelination

[Term]
id: GO:0031642
name: negative regulation of myelination
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of a myelin sheath around nerve axons." [GOC:mah]
synonym: "down regulation of myelination" EXACT []
synonym: "down-regulation of myelination" EXACT []
synonym: "downregulation of myelination" EXACT []
synonym: "inhibition of myelination" NARROW []
is_a: GO:0031641 ! regulation of myelination
is_a: GO:0031645 ! negative regulation of neurological system process
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051961 ! negative regulation of nervous system development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042552 ! myelination
relationship: negatively_regulates GO:0042552 ! myelination

[Term]
id: GO:0031643
name: positive regulation of myelination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the formation of a myelin sheath around nerve axons." [GOC:mah]
synonym: "activation of myelination" NARROW []
synonym: "stimulation of myelination" NARROW []
synonym: "up regulation of myelination" EXACT []
synonym: "up-regulation of myelination" EXACT []
synonym: "upregulation of myelination" EXACT []
is_a: GO:0031641 ! regulation of myelination
is_a: GO:0031646 ! positive regulation of neurological system process
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051962 ! positive regulation of nervous system development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042552 ! myelination
relationship: positively_regulates GO:0042552 ! myelination

[Term]
id: GO:0031644
name: regulation of neurological system process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of neurological system." [GOC:dph, GOC:mah, GOC:tb]
synonym: "regulation of neurological process" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of neurophysiological process" EXACT []
is_a: GO:0044057 ! regulation of system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050877 ! neurological system process
relationship: regulates GO:0050877 ! neurological system process

[Term]
id: GO:0031645
name: negative regulation of neurological system process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a neurophysiological process." [GOC:dph, GOC:mah, GOC:tb]
synonym: "down regulation of neurological process" EXACT []
synonym: "down-regulation of neurological process" EXACT []
synonym: "downregulation of neurological process" EXACT []
synonym: "inhibition of neurological process" NARROW []
synonym: "negative regulation of neurological process" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of neurophysiological process" EXACT []
is_a: GO:0031644 ! regulation of neurological system process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0050877 ! neurological system process
relationship: negatively_regulates GO:0050877 ! neurological system process

[Term]
id: GO:0031646
name: positive regulation of neurological system process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a neurophysiological process." [GOC:dph, GOC:mah, GOC:tb]
synonym: "activation of neurological process" NARROW []
synonym: "positive regulation of neurological process" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of neurophysiological process" EXACT []
synonym: "stimulation of neurological process" NARROW []
synonym: "up regulation of neurological process" EXACT []
synonym: "up-regulation of neurological process" EXACT []
synonym: "upregulation of neurological process" EXACT []
is_a: GO:0031644 ! regulation of neurological system process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0050877 ! neurological system process
relationship: positively_regulates GO:0050877 ! neurological system process

[Term]
id: GO:0031647
name: regulation of protein stability
namespace: biological_process
def: "Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0031648
name: protein destabilization
namespace: biological_process
def: "Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation." [GOC:mah]
synonym: "negative regulation of protein stability" EXACT []
synonym: "protein destabilisation" EXACT [GOC:ah]
is_a: GO:0031647 ! regulation of protein stability

[Term]
id: GO:0031649
name: heat generation
namespace: biological_process
def: "Any homeostatic process in which an organism produces heat, thereby raising its internal temperature." [GOC:mah]
is_a: GO:0001659 ! temperature homeostasis

[Term]
id: GO:0031650
name: regulation of heat generation
namespace: biological_process
def: "Any process that modulates the rate or extent of heat generation." [GOC:dph, GOC:mah, GOC:tb]
is_a: GO:0032844 ! regulation of homeostatic process
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031649 ! heat generation
relationship: regulates GO:0031649 ! heat generation

[Term]
id: GO:0031651
name: negative regulation of heat generation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate or extent of heat generation." [GOC:dph, GOC:mah, GOC:tb]
synonym: "down regulation of heat generation" EXACT []
synonym: "down-regulation of heat generation" EXACT []
synonym: "downregulation of heat generation" EXACT []
synonym: "inhibition of heat generation" NARROW []
is_a: GO:0031650 ! regulation of heat generation
is_a: GO:0032845 ! negative regulation of homeostatic process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0031649 ! heat generation
relationship: negatively_regulates GO:0031649 ! heat generation

[Term]
id: GO:0031652
name: positive regulation of heat generation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of heat generation." [GOC:dph, GOC:mah, GOC:tb]
synonym: "activation of heat generation" NARROW []
synonym: "stimulation of heat generation" NARROW []
synonym: "up regulation of heat generation" EXACT []
synonym: "up-regulation of heat generation" EXACT []
synonym: "upregulation of heat generation" EXACT []
is_a: GO:0031650 ! regulation of heat generation
is_a: GO:0032846 ! positive regulation of homeostatic process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0031649 ! heat generation
relationship: positively_regulates GO:0031649 ! heat generation

[Term]
id: GO:0031653
name: heat dissipation
namespace: biological_process
def: "Any homeostatic process in which an organism releases excess heat to the environment, thereby lowering its internal temperature." [GOC:mah]
is_a: GO:0001659 ! temperature homeostasis

[Term]
id: GO:0031654
name: regulation of heat dissipation
namespace: biological_process
def: "Any process that modulates the rate or extent of heat dissipation." [GOC:dph, GOC:mah, GOC:tb]
is_a: GO:0032844 ! regulation of homeostatic process
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031653 ! heat dissipation
relationship: regulates GO:0031653 ! heat dissipation

[Term]
id: GO:0031655
name: negative regulation of heat dissipation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate or extent of heat dissipation." [GOC:dph, GOC:mah, GOC:tb]
synonym: "down regulation of heat dissipation" EXACT []
synonym: "down-regulation of heat dissipation" EXACT []
synonym: "downregulation of heat dissipation" EXACT []
synonym: "inhibition of heat dissipation" NARROW []
is_a: GO:0031654 ! regulation of heat dissipation
is_a: GO:0032845 ! negative regulation of homeostatic process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0031653 ! heat dissipation
relationship: negatively_regulates GO:0031653 ! heat dissipation

[Term]
id: GO:0031656
name: positive regulation of heat dissipation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of heat dissipation." [GOC:dph, GOC:mah, GOC:tb]
synonym: "activation of heat dissipation" NARROW []
synonym: "stimulation of heat dissipation" NARROW []
synonym: "up regulation of heat dissipation" EXACT []
synonym: "up-regulation of heat dissipation" EXACT []
synonym: "upregulation of heat dissipation" EXACT []
is_a: GO:0031654 ! regulation of heat dissipation
is_a: GO:0032846 ! positive regulation of homeostatic process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0031653 ! heat dissipation
relationship: positively_regulates GO:0031653 ! heat dissipation

[Term]
id: GO:0031657
name: regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
namespace: biological_process
def: "Any process that controls the frequency, rate or extent of G1 cyclin-dependent protein serine/threonine kinase activity contributing to the G1/S transition of the cell cycle." [GOC:mtg_cell_cycle, GOC:pr]
synonym: "G1/S-specific regulation of cyclin-dependent protein kinase activity" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of cyclin-dependent protein kinase activity during G1/S" RELATED [GOC:dph, GOC:tb]
synonym: "regulation of cyclin-dependent protein kinase activity involved in G1/S" BROAD []
is_a: GO:0000079 ! regulation of cyclin-dependent protein serine/threonine kinase activity
is_a: GO:2000045 ! regulation of G1/S transition of mitotic cell cycle
intersection_of: GO:0000079 ! regulation of cyclin-dependent protein serine/threonine kinase activity
intersection_of: regulates GO:0000082 ! G1/S transition of mitotic cell cycle
relationship: regulates GO:0000082 ! G1/S transition of mitotic cell cycle

[Term]
id: GO:0031658
name: negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity contributing to the G1/S transition of the cell cycle." [GOC:dph, GOC:mah, GOC:pr, GOC:tb]
synonym: "G1/S-specific down regulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "G1/S-specific down-regulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "G1/S-specific downregulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "G1/S-specific inhibition of cyclin-dependent protein kinase activity" NARROW []
synonym: "G1/S-specific negative regulation of cyclin-dependent protein kinase activity" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of cyclin-dependent protein kinase activity during G1/S" RELATED [GOC:dph, GOC:tb]
synonym: "negative regulation of cyclin-dependent protein kinase activity involved in G1/S" BROAD []
is_a: GO:0031657 ! regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
is_a: GO:0045736 ! negative regulation of cyclin-dependent protein serine/threonine kinase activity
intersection_of: GO:0045736 ! negative regulation of cyclin-dependent protein serine/threonine kinase activity
intersection_of: regulates GO:0000082 ! G1/S transition of mitotic cell cycle
relationship: regulates GO:0000082 ! G1/S transition of mitotic cell cycle

[Term]
id: GO:0031659
name: positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity contributing to the G1/S transition of the cell cycle." [GOC:dph, GOC:mah, GOC:pr, GOC:tb]
synonym: "G1/S-specific activation of cyclin-dependent protein kinase activity" NARROW []
synonym: "G1/S-specific positive regulation of cyclin-dependent protein kinase activity" EXACT [GOC:dph, GOC:tb]
synonym: "G1/S-specific stimulation of cyclin-dependent protein kinase activity" NARROW []
synonym: "G1/S-specific up regulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "G1/S-specific up-regulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "G1/S-specific upregulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "positive regulation of cyclin-dependent protein kinase activity during G1/S" RELATED [GOC:dph, GOC:tb]
synonym: "positive regulation of cyclin-dependent protein kinase activity involved in G1/S" BROAD []
is_a: GO:0031657 ! regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
is_a: GO:0045737 ! positive regulation of cyclin-dependent protein serine/threonine kinase activity
intersection_of: GO:0045737 ! positive regulation of cyclin-dependent protein serine/threonine kinase activity
intersection_of: regulates GO:0000082 ! G1/S transition of mitotic cell cycle
relationship: regulates GO:0000082 ! G1/S transition of mitotic cell cycle

[Term]
id: GO:0031660
name: regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity contributing to the G2/M transition of the cell cycle." [GOC:dph, GOC:mah, GOC:pr, GOC:tb]
synonym: "G2/M-specific regulation of cyclin-dependent protein kinase activity" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of cyclin-dependent protein kinase activity during G2/M" RELATED [GOC:dph, GOC:tb]
synonym: "regulation of cyclin-dependent protein kinase activity involved in G2/M" BROAD []
is_a: GO:0000079 ! regulation of cyclin-dependent protein serine/threonine kinase activity
is_a: GO:0010389 ! regulation of G2/M transition of mitotic cell cycle
intersection_of: GO:0000079 ! regulation of cyclin-dependent protein serine/threonine kinase activity
intersection_of: regulates GO:0000086 ! G2/M transition of mitotic cell cycle
relationship: regulates GO:0000086 ! G2/M transition of mitotic cell cycle

[Term]
id: GO:0031661
name: negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity contributing to the G2/M transition of the cell cycle." [GOC:dph, GOC:mah, GOC:pr, GOC:tb]
synonym: "G2/M-specific down regulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "G2/M-specific down-regulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "G2/M-specific downregulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "G2/M-specific inhibition of cyclin-dependent protein kinase activity" NARROW []
synonym: "G2/M-specific negative regulation of cyclin-dependent protein kinase activity" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of cyclin-dependent protein kinase activity during G2/M" RELATED [GOC:dph, GOC:tb]
synonym: "negative regulation of cyclin-dependent protein kinase activity involved in G2/M" BROAD []
is_a: GO:0031660 ! regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle
is_a: GO:0045736 ! negative regulation of cyclin-dependent protein serine/threonine kinase activity
intersection_of: GO:0045736 ! negative regulation of cyclin-dependent protein serine/threonine kinase activity
intersection_of: regulates GO:0000086 ! G2/M transition of mitotic cell cycle
relationship: regulates GO:0000086 ! G2/M transition of mitotic cell cycle

[Term]
id: GO:0031662
name: positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity involved in the G2/M transition of the cell cycle." [GOC:dph, GOC:mah, GOC:pr, GOC:tb]
synonym: "G2/M-specific activation of cyclin-dependent protein kinase activity" NARROW []
synonym: "G2/M-specific positive regulation of cyclin-dependent protein kinase activity" EXACT [GOC:dph, GOC:tb]
synonym: "G2/M-specific stimulation of cyclin-dependent protein kinase activity" NARROW []
synonym: "G2/M-specific up regulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "G2/M-specific up-regulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "G2/M-specific upregulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "positive regulation of cyclin-dependent protein kinase activity during G2/M" RELATED [GOC:dph, GOC:tb]
synonym: "positive regulation of cyclin-dependent protein kinase activity involved in G2/M" BROAD []
is_a: GO:0031660 ! regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle
is_a: GO:0045737 ! positive regulation of cyclin-dependent protein serine/threonine kinase activity
intersection_of: GO:0045737 ! positive regulation of cyclin-dependent protein serine/threonine kinase activity
intersection_of: regulates GO:0000086 ! G2/M transition of mitotic cell cycle
relationship: regulates GO:0000086 ! G2/M transition of mitotic cell cycle

[Term]
id: GO:0031663
name: lipopolysaccharide-mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of a lipopolysaccharide (LPS) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Lipopolysaccharides are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system." [GOC:mah, GOC:signaling, PMID:15379975]
synonym: "lipopolysaccharide-mediated signalling pathway" EXACT []
synonym: "LPS-mediated signaling pathway" EXACT []
is_a: GO:0007166 ! cell surface receptor signaling pathway
relationship: part_of GO:0071222 ! cellular response to lipopolysaccharide

[Term]
id: GO:0031664
name: regulation of lipopolysaccharide-mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of signaling in response to detection of lipopolysaccharide." [GOC:mah]
synonym: "regulation of lipopolysaccharide-mediated signalling pathway" EXACT []
synonym: "regulation of LPS-mediated signaling pathway" EXACT []
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0032101 ! regulation of response to external stimulus
is_a: GO:0043900 ! regulation of multi-organism process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031663 ! lipopolysaccharide-mediated signaling pathway
relationship: regulates GO:0031663 ! lipopolysaccharide-mediated signaling pathway

[Term]
id: GO:0031665
name: negative regulation of lipopolysaccharide-mediated signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signaling in response to detection of lipopolysaccharide." [GOC:mah]
synonym: "down regulation of lipopolysaccharide-mediated signaling pathway" EXACT []
synonym: "down-regulation of lipopolysaccharide-mediated signaling pathway" EXACT []
synonym: "downregulation of lipopolysaccharide-mediated signaling pathway" EXACT []
synonym: "inhibition of lipopolysaccharide-mediated signaling pathway" NARROW []
synonym: "negative regulation of lipopolysaccharide-mediated signalling pathway" EXACT []
synonym: "negative regulation of LPS-mediated signaling pathway" EXACT []
is_a: GO:0002832 ! negative regulation of response to biotic stimulus
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0031664 ! regulation of lipopolysaccharide-mediated signaling pathway
is_a: GO:0032102 ! negative regulation of response to external stimulus
is_a: GO:0043901 ! negative regulation of multi-organism process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0031663 ! lipopolysaccharide-mediated signaling pathway
relationship: negatively_regulates GO:0031663 ! lipopolysaccharide-mediated signaling pathway

[Term]
id: GO:0031666
name: positive regulation of lipopolysaccharide-mediated signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of signaling in response to detection of lipopolysaccharide." [GOC:mah]
synonym: "activation of lipopolysaccharide-mediated signaling pathway" NARROW []
synonym: "positive regulation of lipopolysaccharide-mediated signalling pathway" EXACT []
synonym: "positive regulation of LPS-mediated signaling pathway" EXACT []
synonym: "stimulation of lipopolysaccharide-mediated signaling pathway" NARROW []
synonym: "up regulation of lipopolysaccharide-mediated signaling pathway" EXACT []
synonym: "up-regulation of lipopolysaccharide-mediated signaling pathway" EXACT []
synonym: "upregulation of lipopolysaccharide-mediated signaling pathway" EXACT []
is_a: GO:0002833 ! positive regulation of response to biotic stimulus
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0031664 ! regulation of lipopolysaccharide-mediated signaling pathway
is_a: GO:0032103 ! positive regulation of response to external stimulus
is_a: GO:0043902 ! positive regulation of multi-organism process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0031663 ! lipopolysaccharide-mediated signaling pathway
relationship: positively_regulates GO:0031663 ! lipopolysaccharide-mediated signaling pathway

[Term]
id: GO:0031667
name: response to nutrient levels
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients." [GOC:mah]
subset: gosubset_prok
is_a: GO:0009991 ! response to extracellular stimulus

[Term]
id: GO:0031668
name: cellular response to extracellular stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus." [GOC:mah]
subset: gosubset_prok
is_a: GO:0007154 ! cell communication
is_a: GO:0009991 ! response to extracellular stimulus
is_a: GO:0051716 ! cellular response to stimulus
is_a: GO:0071496 ! cellular response to external stimulus

[Term]
id: GO:0031669
name: cellular response to nutrient levels
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients." [GOC:mah]
subset: gosubset_prok
is_a: GO:0031667 ! response to nutrient levels
is_a: GO:0031668 ! cellular response to extracellular stimulus

[Term]
id: GO:0031670
name: cellular response to nutrient
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus." [GOC:mah]
is_a: GO:0007584 ! response to nutrient
is_a: GO:0031669 ! cellular response to nutrient levels
is_a: GO:0070887 ! cellular response to chemical stimulus

[Term]
id: GO:0031671
name: primary cell septum biogenesis
namespace: biological_process
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a primary cell septum following nuclear division." [GOC:jl]
is_a: GO:0044085 ! cellular component biogenesis
is_a: GO:1902410 ! mitotic cytokinetic process
relationship: part_of GO:0000917 ! barrier septum assembly
relationship: part_of GO:0061640 ! cytoskeleton-dependent cytokinesis

[Term]
id: GO:0031672
name: A band
namespace: cellular_component
def: "The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line." [ISBN:0321204131]
synonym: "A disc" EXACT []
synonym: "anisotropic disc" EXACT []
synonym: "Q disc" EXACT []
synonym: "transverse disc" EXACT []
xref: Wikipedia:Sarcomere#bands
is_a: GO:0044449 ! contractile fiber part
relationship: part_of GO:0030017 ! sarcomere

[Term]
id: GO:0031673
name: H zone
namespace: cellular_component
def: "A relatively pale zone traversing the center of the A band of a sarcomere, visible in relaxed muscle fibers; consists of the central portion of thick (myosin) filaments that are not overlapped by thin (actin) filaments." [GOC:mtg_muscle, ISBN:0321204131]
synonym: "H band" EXACT []
synonym: "H disc" EXACT []
xref: Wikipedia:Sarcomere#bands
is_a: GO:0044449 ! contractile fiber part
relationship: part_of GO:0031672 ! A band

[Term]
id: GO:0031674
name: I band
namespace: cellular_component
def: "A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end." [ISBN:0321204131]
synonym: "I disc" EXACT []
synonym: "isotropic disc" EXACT []
synonym: "J disc" EXACT []
xref: Wikipedia:Sarcomere#bands
is_a: GO:0044449 ! contractile fiber part
relationship: part_of GO:0030017 ! sarcomere

[Term]
id: GO:0031676
name: plasma membrane-derived thylakoid membrane
namespace: cellular_component
def: "The pigmented membrane of a plasma membrane-derived thylakoid." [GOC:mah, GOC:mtg_sensu]
synonym: "plasma membrane thylakoid membrane" EXACT []
is_a: GO:0042651 ! thylakoid membrane
is_a: GO:0042717 ! plasma membrane-derived chromatophore membrane
is_a: GO:0044422 ! organelle part
is_a: GO:0098590 ! plasma membrane region
relationship: part_of GO:0030075 ! bacterial thylakoid

[Term]
id: GO:0031679
name: NADH dehydrogenase (plastoquinone) activity
namespace: molecular_function
alt_id: GO:0030024
def: "Catalysis of the reaction: NADH + H+ + plastoquinone = NAD+ + plastoquinol." [EC:1.6.99.6, GOC:mah]
synonym: "NADH:plastoquinone reductase activity" EXACT []
is_a: GO:0050136 ! NADH dehydrogenase (quinone) activity

[Term]
id: GO:0031680
name: G-protein beta/gamma-subunit complex
namespace: cellular_component
def: "The heterodimer formed by the beta and gamma subunits of a heterotrimeric G protein, which dissociates from the alpha subunit upon guanine nuclotide exchange." [GOC:mah]
comment: See also the cellular component term 'heterotrimeric G-protein complex ; GO:0005834'.
synonym: "G-beta/G-gamma complex" EXACT []
synonym: "heterotrimeric G-protein GTPase, beta-subunit" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0031681
name: G-protein beta-subunit binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a G-protein beta subunit." [GOC:mah]
synonym: "G-beta protein subunit binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0031682
name: G-protein gamma-subunit binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a G-protein gamma subunit." [GOC:mah]
synonym: "G-gamma protein subunit binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0031683
name: G-protein beta/gamma-subunit complex binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a complex of G-protein beta/gamma subunits." [GOC:nln, GOC:vw]
is_a: GO:0032403 ! protein complex binding

[Term]
id: GO:0031684
name: heterotrimeric G-protein complex cycle
namespace: biological_process
def: "The series of molecular events that generate a signal through the activation of G-protein subunits and recycling of these subunits." [GOC:nln]
is_a: GO:0043087 ! regulation of GTPase activity
relationship: part_of GO:0007186 ! G-protein coupled receptor signaling pathway

[Term]
id: GO:0031685
name: adenosine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an adenosine receptor." [GOC:mah, GOC:nln]
synonym: "adenosine receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein coupled receptor binding

[Term]
id: GO:0031686
name: A1 adenosine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an A1 adenosine receptor." [GOC:mah, GOC:nln]
synonym: "A1 adenosine receptor ligand" NARROW []
is_a: GO:0031685 ! adenosine receptor binding

[Term]
id: GO:0031687
name: A2A adenosine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an A2A adenosine receptor." [GOC:mah, GOC:nln]
synonym: "A2A adenosine receptor ligand" NARROW []
is_a: GO:0031685 ! adenosine receptor binding

[Term]
id: GO:0031688
name: A2B adenosine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an A2B adenosine receptor." [GOC:mah, GOC:nln]
synonym: "A2B adenosine receptor ligand" NARROW []
is_a: GO:0031685 ! adenosine receptor binding

[Term]
id: GO:0031689
name: A3 adenosine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an A3 adenosine receptor." [GOC:mah, GOC:nln]
synonym: "A3 adenosine receptor ligand" NARROW []
is_a: GO:0031685 ! adenosine receptor binding

[Term]
id: GO:0031690
name: adrenergic receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an adrenergic receptor." [GOC:mah, GOC:nln]
synonym: "adrenergic receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein coupled receptor binding

[Term]
id: GO:0031691
name: alpha-1A adrenergic receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an alpha-1A adrenergic receptor." [GOC:mah, GOC:nln]
synonym: "alpha-1A adrenergic receptor ligand" NARROW []
is_a: GO:0031690 ! adrenergic receptor binding

[Term]
id: GO:0031692
name: alpha-1B adrenergic receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an alpha-1B adrenergic receptor." [GOC:mah, GOC:nln]
synonym: "alpha-1B adrenergic receptor ligand" NARROW []
is_a: GO:0031690 ! adrenergic receptor binding

[Term]
id: GO:0031693
name: alpha-1D adrenergic receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an alpha-1D adrenergic receptor." [GOC:mah, GOC:nln]
synonym: "alpha-1D adrenergic receptor ligand" NARROW []
is_a: GO:0031690 ! adrenergic receptor binding

[Term]
id: GO:0031694
name: alpha-2A adrenergic receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an alpha-2A adrenergic receptor." [GOC:mah, GOC:nln]
synonym: "alpha-2A adrenergic receptor ligand" NARROW []
is_a: GO:0031690 ! adrenergic receptor binding

[Term]
id: GO:0031695
name: alpha-2B adrenergic receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an alpha-2B adrenergic receptor." [GOC:mah, GOC:nln]
synonym: "alpha-2B adrenergic receptor ligand" NARROW []
is_a: GO:0031690 ! adrenergic receptor binding

[Term]
id: GO:0031696
name: alpha-2C adrenergic receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an alpha-2C adrenergic receptor." [GOC:mah, GOC:nln]
synonym: "alpha-2C adrenergic receptor ligand" NARROW []
is_a: GO:0031690 ! adrenergic receptor binding

[Term]
id: GO:0031697
name: beta-1 adrenergic receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a beta-1 adrenergic receptor." [GOC:mah, GOC:nln]
synonym: "beta-1 adrenergic receptor ligand" NARROW []
is_a: GO:0031690 ! adrenergic receptor binding

[Term]
id: GO:0031698
name: beta-2 adrenergic receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a beta-2 adrenergic receptor." [GOC:mah, GOC:nln]
synonym: "beta-2 adrenergic receptor ligand" NARROW []
is_a: GO:0031690 ! adrenergic receptor binding

[Term]
id: GO:0031699
name: beta-3 adrenergic receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a beta-3 adrenergic receptor." [GOC:mah, GOC:nln]
synonym: "beta-3 adrenergic receptor ligand" NARROW []
is_a: GO:0031690 ! adrenergic receptor binding

[Term]
id: GO:0031700
name: adrenomedullin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an adrenomedullin receptor." [GOC:mah, GOC:nln]
synonym: "adrenomedullin receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein coupled receptor binding

[Term]
id: GO:0031701
name: angiotensin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an angiotensin receptor." [GOC:mah, GOC:nln]
synonym: "angiotensin receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein coupled receptor binding

[Term]
id: GO:0031702
name: type 1 angiotensin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 1 angiotensin receptor." [GOC:mah, GOC:nln]
synonym: "AT1 receptor binding" EXACT []
synonym: "type 1 angiotensin receptor ligand" NARROW []
is_a: GO:0031701 ! angiotensin receptor binding

[Term]
id: GO:0031703
name: type 2 angiotensin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 2 angiotensin receptor." [GOC:mah, GOC:nln]
synonym: "AT2 receptor binding" EXACT []
synonym: "type 2 angiotensin receptor ligand" NARROW []
is_a: GO:0031701 ! angiotensin receptor binding

[Term]
id: GO:0031704
name: apelin receptor binding
namespace: molecular_function
alt_id: GO:0042569
def: "Interacting selectively and non-covalently with an apelin receptor." [GOC:mah, GOC:nln, GOC:vp, PMID:12787050]
synonym: "apelin receptor ligand" NARROW []
synonym: "APJ receptor binding" EXACT []
is_a: GO:0071855 ! neuropeptide receptor binding

[Term]
id: GO:0031705
name: bombesin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a bombesin receptor." [GOC:mah, GOC:nln]
synonym: "bombesin receptor ligand" NARROW []
is_a: GO:0071855 ! neuropeptide receptor binding

[Term]
id: GO:0031706
name: subtype 3 bombesin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a subtype 3 bombesin receptor." [GOC:mah, GOC:nln]
synonym: "subtype 3 bombesin receptor ligand" NARROW []
is_a: GO:0031705 ! bombesin receptor binding

[Term]
id: GO:0031707
name: endothelin A receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an endothelin A receptor." [GOC:mah, GOC:nln]
synonym: "endothelin A receptor ligand" NARROW []
synonym: "endothelin-1 receptor binding" EXACT []
is_a: GO:0031705 ! bombesin receptor binding

[Term]
id: GO:0031708
name: endothelin B receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an endothelin B receptor." [GOC:mah, GOC:nln]
synonym: "endothelin B receptor ligand" NARROW []
is_a: GO:0031705 ! bombesin receptor binding

[Term]
id: GO:0031709
name: gastrin-releasing peptide receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a gastrin-releasing peptide receptor." [GOC:mah, GOC:nln]
synonym: "gastrin-releasing peptide receptor ligand" NARROW []
synonym: "GRP receptor binding" EXACT []
is_a: GO:0031705 ! bombesin receptor binding

[Term]
id: GO:0031710
name: neuromedin B receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a neuromedin B receptor." [GOC:mah, GOC:nln]
synonym: "neuromedin B receptor ligand" NARROW []
is_a: GO:0031705 ! bombesin receptor binding

[Term]
id: GO:0031711
name: bradykinin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a bradykinin receptor." [GOC:mah, GOC:nln]
synonym: "bradykinin receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein coupled receptor binding

[Term]
id: GO:0031712
name: B1 bradykinin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a B1 bradykinin receptor." [GOC:mah, GOC:nln]
synonym: "B1 bradykinin receptor ligand" NARROW []
is_a: GO:0031711 ! bradykinin receptor binding

[Term]
id: GO:0031713
name: B2 bradykinin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a B2 bradykinin receptor." [GOC:mah, GOC:nln]
synonym: "B2 bradykinin receptor ligand" NARROW []
is_a: GO:0031711 ! bradykinin receptor binding

[Term]
id: GO:0031714
name: C5a anaphylatoxin chemotactic receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a C5a anaphylatoxin chemotactic receptor." [GOC:mah, GOC:nln]
synonym: "C5a anaphylatoxin chemotactic receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein coupled receptor binding

[Term]
id: GO:0031715
name: C5L2 anaphylatoxin chemotactic receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a C5L2 anaphylatoxin chemotactic receptor." [GOC:mah, GOC:nln]
synonym: "C5L2 anaphylatoxin chemotactic receptor ligand" NARROW []
is_a: GO:0031714 ! C5a anaphylatoxin chemotactic receptor binding

[Term]
id: GO:0031716
name: calcitonin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a calcitonin receptor." [GOC:mah, GOC:nln]
synonym: "calcitonin receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein coupled receptor binding

[Term]
id: GO:0031717
name: cannabinoid receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a cannabinoid receptor." [GOC:mah, GOC:nln]
synonym: "cannabinoid receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein coupled receptor binding

[Term]
id: GO:0031718
name: type 1 cannabinoid receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 1 cannabinoid receptor." [GOC:mah, GOC:nln]
synonym: "type 1 cannabinoid receptor ligand" NARROW []
is_a: GO:0031717 ! cannabinoid receptor binding

[Term]
id: GO:0031719
name: type 2 cannabinoid receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 2 cannabinoid receptor." [GOC:mah, GOC:nln]
synonym: "type 2 cannabinoid receptor ligand" NARROW []
is_a: GO:0031717 ! cannabinoid receptor binding

[Term]
id: GO:0031720
name: haptoglobin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a haptoglobin, any alpha2 globulin of blood plasma that can combine with free oxyhemoglobin to form a stable complex." [GOC:mah, ISBN:0198506732]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0031721
name: hemoglobin alpha binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a hemoglobin alpha chain." [GOC:mah]
is_a: GO:0030492 ! hemoglobin binding

[Term]
id: GO:0031722
name: hemoglobin beta binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a hemoglobin beta chain." [GOC:mah]
is_a: GO:0030492 ! hemoglobin binding

[Term]
id: GO:0031723
name: CXCR4 chemokine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a CXCR4 chemokine receptor." [GOC:mah, GOC:nln]
synonym: "CXCR4 chemokine receptor ligand" NARROW []
synonym: "stromal cell-derived factor 1 receptor binding" EXACT []
is_a: GO:0045236 ! CXCR chemokine receptor binding

[Term]
id: GO:0031724
name: CXCR5 chemokine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a CXCR5 chemokine receptor." [GOC:mah, GOC:nln]
synonym: "CXCR5 chemokine receptor ligand" NARROW []
synonym: "type 1 Burkitt's lymphoma receptor binding" EXACT []
is_a: GO:0045236 ! CXCR chemokine receptor binding

[Term]
id: GO:0031725
name: CXCR6 chemokine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a CXCR6 chemokine receptor." [GOC:mah, GOC:nln]
synonym: "bonzo receptor binding" EXACT []
synonym: "CXCR6 chemokine receptor ligand" NARROW []
synonym: "STRL33 receptor binding" EXACT []
is_a: GO:0045236 ! CXCR chemokine receptor binding

[Term]
id: GO:0031726
name: CCR1 chemokine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a CCR1 chemokine receptor." [GOC:mah, GOC:nln]
synonym: "CCR1 chemokine receptor ligand" NARROW []
synonym: "macrophage inflammatory protein-1 alpha receptor binding" EXACT []
is_a: GO:0048020 ! CCR chemokine receptor binding

[Term]
id: GO:0031727
name: CCR2 chemokine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a CCR2 chemokine receptor." [GOC:mah, GOC:nln]
synonym: "CCR2 chemokine receptor ligand" NARROW []
synonym: "monocyte chemoattractant protein 1 receptor binding" EXACT []
is_a: GO:0048020 ! CCR chemokine receptor binding

[Term]
id: GO:0031728
name: CCR3 chemokine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a CCR3 chemokine receptor." [GOC:mah, GOC:nln]
synonym: "CCR3 chemokine receptor ligand" NARROW []
synonym: "eosinophil eotaxin receptor binding" EXACT []
is_a: GO:0048020 ! CCR chemokine receptor binding

[Term]
id: GO:0031729
name: CCR4 chemokine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a CCR4 chemokine receptor." [GOC:mah, GOC:nln]
synonym: "CCR4 chemokine receptor ligand" NARROW []
is_a: GO:0048020 ! CCR chemokine receptor binding

[Term]
id: GO:0031730
name: CCR5 chemokine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a CCR5 chemokine receptor." [GOC:mah, GOC:nln]
synonym: "CCR5 chemokine receptor ligand" NARROW []
is_a: GO:0048020 ! CCR chemokine receptor binding

[Term]
id: GO:0031731
name: CCR6 chemokine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a CCR6 chemokine receptor." [GOC:mah, GOC:nln]
synonym: "CCR6 chemokine receptor ligand" NARROW []
synonym: "LARC receptor binding" EXACT []
is_a: GO:0048020 ! CCR chemokine receptor binding

[Term]
id: GO:0031732
name: CCR7 chemokine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a CCR7 chemokine receptor." [GOC:mah, GOC:nln]
synonym: "CCR7 chemokine receptor ligand" NARROW []
synonym: "MIP-3 beta receptor binding" EXACT []
synonym: "type 1 EBV-induced G-protein coupled receptor binding" EXACT []
is_a: GO:0048020 ! CCR chemokine receptor binding

[Term]
id: GO:0031733
name: CCR8 chemokine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a CCR8 chemokine receptor." [GOC:mah, GOC:nln]
synonym: "CCR8 chemokine receptor ligand" NARROW []
is_a: GO:0048020 ! CCR chemokine receptor binding

[Term]
id: GO:0031734
name: CCR9 chemokine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a CCR9 chemokine receptor." [GOC:mah, GOC:nln]
synonym: "CCR9 chemokine receptor ligand" NARROW []
is_a: GO:0048020 ! CCR chemokine receptor binding

[Term]
id: GO:0031735
name: CCR10 chemokine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a CCR10 chemokine receptor." [GOC:mah, GOC:nln]
synonym: "CCR10 chemokine receptor ligand" NARROW []
is_a: GO:0048020 ! CCR chemokine receptor binding

[Term]
id: GO:0031736
name: CCR11 chemokine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a CCR11 chemokine receptor." [GOC:mah, GOC:nln]
synonym: "CCR11 chemokine receptor ligand" NARROW []
is_a: GO:0048020 ! CCR chemokine receptor binding

[Term]
id: GO:0031737
name: CX3C chemokine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a CX3C chemokine receptor." [GOC:mah, GOC:nln]
synonym: "CX3C chemokine receptor ligand" NARROW []
synonym: "fractalkine receptor binding" EXACT []
is_a: GO:0042379 ! chemokine receptor binding

[Term]
id: GO:0031738
name: XCR1 chemokine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a XCR1 chemokine receptor." [GOC:mah, GOC:nln]
synonym: "lymphotactin receptor binding" EXACT []
synonym: "XCR1 chemokine receptor ligand" NARROW []
is_a: GO:0042379 ! chemokine receptor binding

[Term]
id: GO:0031739
name: cholecystokinin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a cholecystokinin receptor." [GOC:mah, GOC:nln]
synonym: "cholecystokinin receptor ligand" NARROW []
is_a: GO:0071855 ! neuropeptide receptor binding

[Term]
id: GO:0031740
name: type A cholecystokinin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type A cholecystokinin receptor." [GOC:mah, GOC:nln]
synonym: "type A cholecystokinin receptor ligand" NARROW []
is_a: GO:0031739 ! cholecystokinin receptor binding

[Term]
id: GO:0031741
name: type B gastrin/cholecystokinin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type B gastrin/cholecystokinin receptor." [GOC:mah, GOC:nln]
synonym: "type B gastrin/cholecystokinin receptor ligand" NARROW []
is_a: GO:0031739 ! cholecystokinin receptor binding

[Term]
id: GO:0031745
name: cysteinyl leukotriene receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a cysteinyl leukotriene receptor." [GOC:mah, GOC:nln]
synonym: "cysteinyl leukotriene receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein coupled receptor binding

[Term]
id: GO:0031746
name: type 1 cysteinyl leukotriene receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 1 cysteinyl leukotriene receptor." [GOC:mah, GOC:nln]
synonym: "type 1 cysteinyl leukotriene receptor ligand" NARROW []
is_a: GO:0031745 ! cysteinyl leukotriene receptor binding

[Term]
id: GO:0031747
name: type 2 cysteinyl leukotriene receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 2 cysteinyl leukotriene receptor." [GOC:mah, GOC:nln]
synonym: "type 2 cysteinyl leukotriene receptor ligand" NARROW []
is_a: GO:0031745 ! cysteinyl leukotriene receptor binding

[Term]
id: GO:0031748
name: D1 dopamine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a D1 dopamine receptor." [GOC:mah, GOC:nln]
synonym: "D1 dopamine receptor ligand" NARROW []
synonym: "D1A dopamine receptor binding" EXACT []
is_a: GO:0050780 ! dopamine receptor binding

[Term]
id: GO:0031749
name: D2 dopamine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a D2 dopamine receptor." [GOC:mah, GOC:nln]
synonym: "D2 dopamine receptor ligand" NARROW []
is_a: GO:0050780 ! dopamine receptor binding

[Term]
id: GO:0031750
name: D3 dopamine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a D3 dopamine receptor." [GOC:mah, GOC:nln]
synonym: "D3 dopamine receptor ligand" NARROW []
is_a: GO:0050780 ! dopamine receptor binding

[Term]
id: GO:0031751
name: D4 dopamine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a D4 dopamine receptor." [GOC:mah, GOC:nln]
synonym: "D4 dopamine receptor ligand" NARROW []
is_a: GO:0050780 ! dopamine receptor binding

[Term]
id: GO:0031752
name: D5 dopamine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a D5 dopamine receptor." [GOC:mah, GOC:nln]
synonym: "D1B dopamine receptor binding" EXACT []
synonym: "D5 dopamine receptor ligand" NARROW []
is_a: GO:0050780 ! dopamine receptor binding

[Term]
id: GO:0031753
name: endothelial differentiation G-protein coupled receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an endothelial differentiation G-protein coupled receptor." [GOC:mah, GOC:nln]
synonym: "endothelial differentiation G-protein coupled receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein coupled receptor binding

[Term]
id: GO:0031754
name: Edg-1 sphingosine 1-phosphate receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an Edg-1 sphingosine 1-phosphate receptor." [GOC:mah, GOC:nln]
synonym: "Edg-1 sphingosine 1-phosphate receptor ligand" NARROW []
is_a: GO:0031753 ! endothelial differentiation G-protein coupled receptor binding

[Term]
id: GO:0031755
name: Edg-2 lysophosphatidic acid receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an Edg-2 lysophosphatidic acid receptor." [GOC:mah, GOC:nln]
synonym: "Edg-2 lysophosphatidic acid receptor ligand" NARROW []
synonym: "LPA1 receptor binding" EXACT []
is_a: GO:0031753 ! endothelial differentiation G-protein coupled receptor binding

[Term]
id: GO:0031756
name: Edg-3 sphingosine 1-phosphate receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an Edg-3 sphingosine 1-phosphate receptor." [GOC:mah, GOC:nln]
synonym: "Edg-3 sphingosine 1-phosphate receptor ligand" NARROW []
is_a: GO:0031753 ! endothelial differentiation G-protein coupled receptor binding

[Term]
id: GO:0031757
name: Edg-4 lysophosphatidic acid receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an Edg-4 lysophosphatidic acid receptor." [GOC:mah, GOC:nln]
synonym: "Edg-4 lysophosphatidic acid receptor ligand" NARROW []
synonym: "LPA2 receptor binding" EXACT []
is_a: GO:0031753 ! endothelial differentiation G-protein coupled receptor binding

[Term]
id: GO:0031758
name: Edg-5 sphingosine 1-phosphate receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an Edg-5 sphingosine 1-phosphate receptor." [GOC:mah, GOC:nln]
synonym: "Edg-5 sphingosine 1-phosphate receptor ligand" NARROW []
is_a: GO:0031753 ! endothelial differentiation G-protein coupled receptor binding

[Term]
id: GO:0031759
name: Edg-6 sphingosine 1-phosphate receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an Edg-6 sphingosine 1-phosphate receptor." [GOC:mah, GOC:nln]
synonym: "Edg-6 sphingosine 1-phosphate receptor ligand" NARROW []
is_a: GO:0031753 ! endothelial differentiation G-protein coupled receptor binding

[Term]
id: GO:0031760
name: Edg-7 lysophosphatidic acid receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an Edg-7 lysophosphatidic acid receptor." [GOC:mah, GOC:nln]
synonym: "Edg-7 lysophosphatidic acid receptor ligand" NARROW []
synonym: "LPA3 receptor binding" EXACT []
is_a: GO:0031753 ! endothelial differentiation G-protein coupled receptor binding

[Term]
id: GO:0031761
name: fMet-Leu-Phe receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a fMet-Leu-Phe receptor." [GOC:mah, GOC:nln]
synonym: "fMet-Leu-Phe receptor ligand" NARROW []
synonym: "N-formyl peptide receptor binding" EXACT []
is_a: GO:0001664 ! G-protein coupled receptor binding

[Term]
id: GO:0031762
name: follicle-stimulating hormone receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a follicle-stimulating hormone receptor." [GOC:mah, GOC:nln]
synonym: "follicle stimulating hormone receptor binding" EXACT []
synonym: "follicle stimulating hormone receptor ligand" NARROW []
synonym: "FSH receptor binding" EXACT []
is_a: GO:0001664 ! G-protein coupled receptor binding

[Term]
id: GO:0031763
name: galanin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a galanin receptor." [GOC:mah, GOC:nln]
synonym: "galanin receptor ligand" NARROW []
is_a: GO:0071855 ! neuropeptide receptor binding

[Term]
id: GO:0031764
name: type 1 galanin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 1 galanin receptor." [GOC:mah, GOC:nln]
synonym: "type 1 galanin receptor ligand" NARROW []
is_a: GO:0031763 ! galanin receptor binding

[Term]
id: GO:0031765
name: type 2 galanin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 2 galanin receptor." [GOC:mah, GOC:nln]
synonym: "type 2 galanin receptor ligand" NARROW []
is_a: GO:0031763 ! galanin receptor binding

[Term]
id: GO:0031766
name: type 3 galanin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 3 galanin receptor." [GOC:mah, GOC:nln]
synonym: "type 3 galanin receptor ligand" NARROW []
is_a: GO:0031763 ! galanin receptor binding

[Term]
id: GO:0031767
name: gastric inhibitory polypeptide receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a gastric inhibitory polypeptide receptor." [GOC:mah, GOC:nln]
synonym: "gastric inhibitory polypeptide receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein coupled receptor binding

[Term]
id: GO:0031768
name: ghrelin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a ghrelin receptor." [GOC:mah, GOC:nln]
synonym: "ghrelin receptor ligand" NARROW []
synonym: "type 1 growth hormone secretagogue GH-releasing peptide receptor binding" EXACT []
is_a: GO:0001664 ! G-protein coupled receptor binding

[Term]
id: GO:0031769
name: glucagon receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a glucagon receptor." [GOC:mah, GOC:nln]
synonym: "glucagon receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein coupled receptor binding

[Term]
id: GO:0031770
name: growth hormone-releasing hormone receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a growth hormone-releasing hormone receptor." [GOC:mah, GOC:nln]
synonym: "growth hormone-releasing hormone receptor ligand" NARROW []
is_a: GO:0071855 ! neuropeptide receptor binding

[Term]
id: GO:0031771
name: type 1 hypocretin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 1 hypocretin receptor." [GOC:mah, GOC:nln]
synonym: "type 1 hypocretin receptor ligand" NARROW []
synonym: "type 1 orexin receptor binding" EXACT []
is_a: GO:0042324 ! hypocretin receptor binding

[Term]
id: GO:0031772
name: type 2 hypocretin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 2 hypocretin receptor." [GOC:mah, GOC:nln]
synonym: "type 2 hypocretin receptor ligand" NARROW []
synonym: "type 2 orexin receptor binding" EXACT []
is_a: GO:0042324 ! hypocretin receptor binding

[Term]
id: GO:0031773
name: kisspeptin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a kisspeptin receptor." [GOC:mah, GOC:nln]
synonym: "G-protein coupled receptor 54 binding" EXACT []
synonym: "hOT7T175 receptor binding" EXACT []
synonym: "hypogonadotropin-1 receptor binding" EXACT []
synonym: "KiSS-1 receptor binding" EXACT []
synonym: "kisspeptin receptor ligand" NARROW []
synonym: "metastin receptor binding" EXACT []
is_a: GO:0071855 ! neuropeptide receptor binding

[Term]
id: GO:0031774
name: leukotriene receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a leukotriene receptor." [GOC:mah, GOC:nln]
synonym: "leukotriene receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein coupled receptor binding

[Term]
id: GO:0031775
name: lutropin-choriogonadotropic hormone receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a lutropin-choriogonadotropic hormone receptor." [GOC:mah, GOC:nln]
synonym: "lutropin-choriogonadotropic hormone receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein coupled receptor binding

[Term]
id: GO:0031776
name: melanin-concentrating hormone receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a melanin-concentrating hormone receptor." [GOC:mah, GOC:nln]
synonym: "melanin-concentrating hormone receptor ligand" NARROW []
is_a: GO:0071855 ! neuropeptide receptor binding

[Term]
id: GO:0031777
name: type 1 melanin-concentrating hormone receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 1 melanin-concentrating hormone receptor." [GOC:mah, GOC:nln]
synonym: "type 1 melanin-concentrating hormone receptor ligand" NARROW []
is_a: GO:0031776 ! melanin-concentrating hormone receptor binding

[Term]
id: GO:0031778
name: type 2 melanin-concentrating hormone receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 2 melanin-concentrating hormone receptor." [GOC:mah, GOC:nln]
synonym: "type 2 melanin-concentrating hormone receptor ligand" NARROW []
is_a: GO:0031776 ! melanin-concentrating hormone receptor binding

[Term]
id: GO:0031779
name: melanocortin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a melanocortin receptor." [GOC:mah, GOC:nln]
synonym: "melanocortin receptor ligand" NARROW []
is_a: GO:0071855 ! neuropeptide receptor binding

[Term]
id: GO:0031780
name: corticotropin hormone receptor binding
namespace: molecular_function
alt_id: GO:0071856
def: "Interacting selectively and non-covalently with a corticotropin hormone receptor." [GOC:dph, GOC:mah, GOC:nln]
synonym: "ACTH receptor binding" EXACT []
synonym: "adrenocorticotropic hormone receptor ligand" NARROW []
synonym: "adrenocorticotropin hormone receptor binding" EXACT [GOC:dph, GOC:tb]
synonym: "adrenocorticotropin receptor binding" EXACT [GOC:dph]
synonym: "corticotropin receptor binding" EXACT [GOC:bf]
is_a: GO:0031779 ! melanocortin receptor binding

[Term]
id: GO:0031781
name: type 3 melanocortin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 3 melanocortin receptor." [GOC:mah, GOC:nln]
synonym: "type 3 melanocortin receptor ligand" NARROW []
is_a: GO:0031779 ! melanocortin receptor binding

[Term]
id: GO:0031782
name: type 4 melanocortin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 4 melanocortin receptor." [GOC:mah, GOC:nln]
synonym: "type 4 melanocortin receptor ligand" NARROW []
is_a: GO:0031779 ! melanocortin receptor binding

[Term]
id: GO:0031783
name: type 5 melanocortin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 5 melanocortin receptor." [GOC:mah, GOC:nln]
synonym: "type 5 melanocortin receptor ligand" NARROW []
is_a: GO:0031779 ! melanocortin receptor binding

[Term]
id: GO:0031784
name: melatonin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a melatonin receptor." [GOC:mah, GOC:nln]
synonym: "melatonin receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein coupled receptor binding

[Term]
id: GO:0031785
name: type 1A melatonin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 1A melatonin receptor." [GOC:mah, GOC:nln]
synonym: "type 1A melatonin receptor ligand" NARROW []
is_a: GO:0031784 ! melatonin receptor binding

[Term]
id: GO:0031786
name: type 1B melatonin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 1B melatonin receptor." [GOC:mah, GOC:nln]
synonym: "type 1B melatonin receptor ligand" NARROW []
is_a: GO:0031784 ! melatonin receptor binding

[Term]
id: GO:0031787
name: H9 melatonin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a H9 melatonin receptor." [GOC:mah, GOC:nln]
synonym: "H9 melatonin receptor ligand" NARROW []
is_a: GO:0031784 ! melatonin receptor binding

[Term]
id: GO:0031788
name: motilin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a motilin receptor." [GOC:mah, GOC:nln]
synonym: "motilin receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein coupled receptor binding

[Term]
id: GO:0031789
name: G-protein coupled acetylcholine receptor binding
namespace: molecular_function
alt_id: GO:0031790
alt_id: GO:0031791
alt_id: GO:0031792
alt_id: GO:0031793
alt_id: GO:0031794
def: "Interacting selectively and non-covalently with a G-protein coupled acetylcholine receptor." [GOC:bf, GOC:mah, GOC:nln]
synonym: "M1 muscarinic acetylcholine receptor binding" NARROW []
synonym: "M1 muscarinic acetylcholine receptor ligand" NARROW []
synonym: "M2 muscarinic acetylcholine receptor binding" NARROW []
synonym: "M2 muscarinic acetylcholine receptor ligand" NARROW []
synonym: "M3 muscarinic acetylcholine receptor binding" NARROW []
synonym: "M3 muscarinic acetylcholine receptor ligand" NARROW []
synonym: "M4 muscarinic acetylcholine receptor binding" NARROW []
synonym: "M4 muscarinic acetylcholine receptor ligand" NARROW []
synonym: "M5 muscarinic acetylcholine receptor binding" NARROW []
synonym: "M5 muscarinic acetylcholine receptor ligand" NARROW []
synonym: "muscarinic acetylcholine receptor binding" EXACT [GOC:bf]
synonym: "muscarinic acetylcholine receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein coupled receptor binding

[Term]
id: GO:0031795
name: G-protein coupled GABA receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a G-protein coupled (metabotropic) GABA receptor." [GOC:mah, GOC:nln]
synonym: "GABAB receptor binding" EXACT []
synonym: "metabotropic GABA receptor binding" EXACT [GOC:bf]
synonym: "metabotropic GABA receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein coupled receptor binding
is_a: GO:0050811 ! GABA receptor binding

[Term]
id: GO:0031796
name: type 1 metabotropic GABA receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 1 metabotropic GABA receptor." [GOC:mah, GOC:nln]
synonym: "type 1 metabotropic GABA receptor ligand" NARROW []
is_a: GO:0031795 ! G-protein coupled GABA receptor binding

[Term]
id: GO:0031797
name: type 2 metabotropic GABA receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 2 metabotropic GABA receptor." [GOC:mah, GOC:nln]
synonym: "type 2 metabotropic GABA receptor ligand" NARROW []
is_a: GO:0031795 ! G-protein coupled GABA receptor binding

[Term]
id: GO:0031798
name: type 1 metabotropic glutamate receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 1 metabotropic glutamate receptor." [GOC:mah, GOC:nln]
synonym: "type 1 metabotropic glutamate receptor ligand" NARROW []
is_a: GO:0035256 ! G-protein coupled glutamate receptor binding

[Term]
id: GO:0031799
name: type 2 metabotropic glutamate receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 2 metabotropic glutamate receptor." [GOC:mah, GOC:nln]
synonym: "type 2 metabotropic glutamate receptor ligand" NARROW []
is_a: GO:0035256 ! G-protein coupled glutamate receptor binding

[Term]
id: GO:0031800
name: type 3 metabotropic glutamate receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 3 metabotropic glutamate receptor." [GOC:mah, GOC:nln]
synonym: "type 3 metabotropic glutamate receptor ligand" NARROW []
is_a: GO:0035256 ! G-protein coupled glutamate receptor binding

[Term]
id: GO:0031801
name: type 4 metabotropic glutamate receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 4 metabotropic glutamate receptor." [GOC:mah, GOC:nln]
synonym: "type 4 metabotropic glutamate receptor ligand" NARROW []
is_a: GO:0035256 ! G-protein coupled glutamate receptor binding

[Term]
id: GO:0031802
name: type 5 metabotropic glutamate receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 5 metabotropic glutamate receptor." [GOC:mah, GOC:nln]
synonym: "type 5 metabotropic glutamate receptor ligand" NARROW []
is_a: GO:0035256 ! G-protein coupled glutamate receptor binding

[Term]
id: GO:0031803
name: type 6 metabotropic glutamate receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 6 metabotropic glutamate receptor." [GOC:mah, GOC:nln]
synonym: "type 6 metabotropic glutamate receptor ligand" NARROW []
is_a: GO:0035256 ! G-protein coupled glutamate receptor binding

[Term]
id: GO:0031804
name: type 7 metabotropic glutamate receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 7 metabotropic glutamate receptor." [GOC:mah, GOC:nln]
synonym: "type 7 metabotropic glutamate receptor ligand" NARROW []
is_a: GO:0035256 ! G-protein coupled glutamate receptor binding

[Term]
id: GO:0031805
name: type 8 metabotropic glutamate receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 8 metabotropic glutamate receptor." [GOC:mah, GOC:nln]
synonym: "type 8 metabotropic glutamate receptor ligand" NARROW []
is_a: GO:0035256 ! G-protein coupled glutamate receptor binding

[Term]
id: GO:0031806
name: G-protein coupled histamine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a G-protein coupled (metabotropic) histamine receptor." [GOC:mah, GOC:nln, PMID:12679144]
synonym: "metabotropic histamine receptor binding" EXACT [GOC:bf]
synonym: "metabotropic histamine receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein coupled receptor binding

[Term]
id: GO:0031807
name: H1 histamine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a H1 histamine receptor." [GOC:mah, GOC:nln]
synonym: "H1 histamine receptor ligand" NARROW []
is_a: GO:0031806 ! G-protein coupled histamine receptor binding

[Term]
id: GO:0031808
name: H2 histamine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a H2 histamine receptor." [GOC:mah, GOC:nln]
synonym: "H2 histamine receptor ligand" NARROW []
is_a: GO:0031806 ! G-protein coupled histamine receptor binding

[Term]
id: GO:0031809
name: H3 histamine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a H3 histamine receptor." [GOC:mah, GOC:nln]
synonym: "H3 histamine receptor ligand" NARROW []
is_a: GO:0031806 ! G-protein coupled histamine receptor binding

[Term]
id: GO:0031810
name: H4 histamine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a H4 histamine receptor." [GOC:mah, GOC:nln]
synonym: "H4 histamine receptor ligand" NARROW []
is_a: GO:0031806 ! G-protein coupled histamine receptor binding

[Term]
id: GO:0031811
name: G-protein coupled nucleotide receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a G-protein coupled (metabotropic) nucleotide receptor." [GOC:mah, GOC:nln]
synonym: "metabotropic nucleotide receptor binding" EXACT [GOC:bf]
synonym: "metabotropic nucleotide receptor ligand" NARROW []
synonym: "P2Y receptor binding" EXACT []
is_a: GO:0001664 ! G-protein coupled receptor binding

[Term]
id: GO:0031812
name: P2Y1 nucleotide receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a P2Y1 nucleotide receptor." [GOC:mah, GOC:nln]
synonym: "P2Y1 nucleotide receptor ligand" NARROW []
is_a: GO:0031811 ! G-protein coupled nucleotide receptor binding

[Term]
id: GO:0031813
name: P2Y2 nucleotide receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a P2Y2 nucleotide receptor." [GOC:mah, GOC:nln]
synonym: "P2Y2 nucleotide receptor ligand" NARROW []
is_a: GO:0031811 ! G-protein coupled nucleotide receptor binding

[Term]
id: GO:0031814
name: P2Y4 nucleotide receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a P2Y4 nucleotide receptor." [GOC:mah, GOC:nln]
synonym: "P2Y4 nucleotide receptor ligand" NARROW []
is_a: GO:0031811 ! G-protein coupled nucleotide receptor binding

[Term]
id: GO:0031815
name: P2Y5 nucleotide receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a P2Y5 nucleotide receptor." [GOC:mah, GOC:nln]
synonym: "P2Y5 nucleotide receptor ligand" NARROW []
is_a: GO:0031811 ! G-protein coupled nucleotide receptor binding

[Term]
id: GO:0031816
name: P2Y6 nucleotide receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a P2Y6 nucleotide receptor." [GOC:mah, GOC:nln]
synonym: "P2Y6 nucleotide receptor ligand" NARROW []
is_a: GO:0031811 ! G-protein coupled nucleotide receptor binding

[Term]
id: GO:0031817
name: P2Y8 nucleotide receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a P2Y8 nucleotide receptor." [GOC:mah, GOC:nln]
synonym: "P2Y8 nucleotide receptor ligand" NARROW []
is_a: GO:0031811 ! G-protein coupled nucleotide receptor binding

[Term]
id: GO:0031818
name: P2Y9 nucleotide receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a P2Y9 nucleotide receptor." [GOC:mah, GOC:nln]
synonym: "P2Y9 nucleotide receptor ligand" NARROW []
is_a: GO:0031811 ! G-protein coupled nucleotide receptor binding

[Term]
id: GO:0031819
name: P2Y10 nucleotide receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a P2Y10 nucleotide receptor." [GOC:mah, GOC:nln]
synonym: "P2Y10 nucleotide receptor ligand" NARROW []
is_a: GO:0031811 ! G-protein coupled nucleotide receptor binding

[Term]
id: GO:0031820
name: P2Y11 nucleotide receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a P2Y11 nucleotide receptor." [GOC:mah, GOC:nln]
synonym: "P2Y11 nucleotide receptor ligand" NARROW []
is_a: GO:0031811 ! G-protein coupled nucleotide receptor binding

[Term]
id: GO:0031821
name: G-protein coupled serotonin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a metabotropic serotonin receptor." [GOC:mah, GOC:nln]
synonym: "metabotropic 5-hydroxytryptamine receptor binding" EXACT []
synonym: "metabotropic serotonin receptor binding" EXACT [GOC:bf]
synonym: "metabotropic serotonin receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein coupled receptor binding

[Term]
id: GO:0031822
name: type 1B serotonin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 1B serotonin receptor." [GOC:mah, GOC:nln]
synonym: "5-hydroxytryptamine 1B receptor binding" EXACT []
synonym: "type 1B serotonin receptor ligand" NARROW []
is_a: GO:0031821 ! G-protein coupled serotonin receptor binding

[Term]
id: GO:0031823
name: type 1D serotonin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 1D serotonin receptor." [GOC:mah, GOC:nln]
synonym: "5-hydroxytryptamine 1D receptor binding" EXACT []
synonym: "type 1D serotonin receptor ligand" NARROW []
is_a: GO:0031821 ! G-protein coupled serotonin receptor binding

[Term]
id: GO:0031824
name: type 1E serotonin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 1E serotonin receptor." [GOC:mah, GOC:nln]
synonym: "5-hydroxytryptamine 1E receptor binding" EXACT []
synonym: "type 1E serotonin receptor ligand" NARROW []
is_a: GO:0031821 ! G-protein coupled serotonin receptor binding

[Term]
id: GO:0031825
name: type 1F serotonin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 1F serotonin receptor." [GOC:mah, GOC:nln]
synonym: "5-hydroxytryptamine 1F receptor binding" EXACT []
synonym: "type 1F serotonin receptor ligand" NARROW []
is_a: GO:0031821 ! G-protein coupled serotonin receptor binding

[Term]
id: GO:0031826
name: type 2A serotonin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 2A serotonin receptor." [GOC:mah, GOC:nln]
synonym: "5-hydroxytryptamine 2A receptor binding" EXACT []
synonym: "type 2A serotonin receptor ligand" NARROW []
is_a: GO:0031821 ! G-protein coupled serotonin receptor binding

[Term]
id: GO:0031827
name: type 2B serotonin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 2B serotonin receptor." [GOC:mah, GOC:nln]
synonym: "5-hydroxytryptamine 2B receptor binding" EXACT []
synonym: "type 2B serotonin receptor ligand" NARROW []
is_a: GO:0031821 ! G-protein coupled serotonin receptor binding

[Term]
id: GO:0031828
name: type 2C serotonin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 2C serotonin receptor." [GOC:mah, GOC:nln]
synonym: "5-hydroxytryptamine 2C receptor binding" EXACT []
synonym: "type 2C serotonin receptor ligand" NARROW []
is_a: GO:0031821 ! G-protein coupled serotonin receptor binding

[Term]
id: GO:0031829
name: type 4 serotonin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 4 serotonin receptor." [GOC:mah, GOC:nln]
synonym: "5-hydroxytryptamine 4 receptor binding" EXACT []
synonym: "type 4 serotonin receptor ligand" NARROW []
is_a: GO:0031821 ! G-protein coupled serotonin receptor binding

[Term]
id: GO:0031830
name: type 5A serotonin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 5A serotonin receptor." [GOC:mah, GOC:nln]
synonym: "5-hydroxytryptamine 5A receptor binding" EXACT []
synonym: "type 5A serotonin receptor ligand" NARROW []
is_a: GO:0031821 ! G-protein coupled serotonin receptor binding

[Term]
id: GO:0031831
name: type 5B serotonin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 5B serotonin receptor." [GOC:mah, GOC:nln]
synonym: "5-hydroxytryptamine 5B receptor binding" EXACT []
synonym: "type 5B serotonin receptor ligand" NARROW []
is_a: GO:0031821 ! G-protein coupled serotonin receptor binding

[Term]
id: GO:0031832
name: type 6 serotonin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 6 serotonin receptor." [GOC:mah, GOC:nln]
synonym: "5-hydroxytryptamine 6 receptor binding" EXACT []
synonym: "type 6 serotonin receptor ligand" NARROW []
is_a: GO:0031821 ! G-protein coupled serotonin receptor binding

[Term]
id: GO:0031833
name: type 7 serotonin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 7 serotonin receptor." [GOC:mah, GOC:nln]
synonym: "5-hydroxytryptamine 7 receptor binding" EXACT []
synonym: "type 7 serotonin receptor ligand" NARROW []
is_a: GO:0031821 ! G-protein coupled serotonin receptor binding

[Term]
id: GO:0031834
name: neurokinin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a neurokinin receptor." [GOC:mah, GOC:nln]
synonym: "neurokinin receptor ligand" NARROW []
is_a: GO:0071855 ! neuropeptide receptor binding

[Term]
id: GO:0031835
name: substance P receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a substance P receptor." [GOC:mah, GOC:nln]
synonym: "neurokinin-1 receptor binding" EXACT []
synonym: "substance P receptor ligand" NARROW []
is_a: GO:0031834 ! neurokinin receptor binding

[Term]
id: GO:0031836
name: neuromedin K receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a neuromedin K receptor." [GOC:mah, GOC:nln]
synonym: "neurokinin-B receptor binding" EXACT []
synonym: "neuromedin K receptor ligand" NARROW []
is_a: GO:0031834 ! neurokinin receptor binding

[Term]
id: GO:0031837
name: substance K receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a substance K receptor." [GOC:mah, GOC:nln]
synonym: "neurokinin-A receptor binding" EXACT []
synonym: "substance K receptor ligand" NARROW []
is_a: GO:0031834 ! neurokinin receptor binding

[Term]
id: GO:0031838
name: haptoglobin-hemoglobin complex
namespace: cellular_component
def: "A protein complex formed by the stable binding of a haptoglobin to hemoglobin." [GOC:mah]
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0031839
name: type 1 neuromedin U receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 1 neuromedin U receptor." [GOC:mah, GOC:nln]
synonym: "type 1 neuromedin U receptor ligand" NARROW []
is_a: GO:0042922 ! neuromedin U receptor binding

[Term]
id: GO:0031840
name: type 2 neuromedin U receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 2 neuromedin U receptor." [GOC:mah, GOC:nln]
synonym: "type 2 neuromedin U receptor ligand" NARROW []
is_a: GO:0042922 ! neuromedin U receptor binding

[Term]
id: GO:0031841
name: neuropeptide Y receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a neuropeptide Y receptor." [GOC:mah, GOC:nln]
synonym: "neuropeptide Y receptor ligand" NARROW []
synonym: "NPY receptor binding" EXACT []
is_a: GO:0071855 ! neuropeptide receptor binding

[Term]
id: GO:0031842
name: type 1 neuropeptide Y receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 1 neuropeptide Y receptor." [GOC:mah, GOC:nln]
synonym: "type 1 neuropeptide Y receptor ligand" NARROW []
is_a: GO:0031841 ! neuropeptide Y receptor binding

[Term]
id: GO:0031843
name: type 2 neuropeptide Y receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 2 neuropeptide Y receptor." [GOC:mah, GOC:nln]
synonym: "type 2 neuropeptide Y receptor ligand" NARROW []
is_a: GO:0031841 ! neuropeptide Y receptor binding

[Term]
id: GO:0031844
name: type 4 neuropeptide Y receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 4 neuropeptide Y receptor." [GOC:mah, GOC:nln]
synonym: "pancreatic polypeptide receptor binding" EXACT []
synonym: "type 4 neuropeptide Y receptor ligand" NARROW []
is_a: GO:0031841 ! neuropeptide Y receptor binding

[Term]
id: GO:0031845
name: type 5 neuropeptide Y receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 5 neuropeptide Y receptor." [GOC:mah, GOC:nln]
synonym: "type 5 neuropeptide Y receptor ligand" NARROW []
is_a: GO:0031841 ! neuropeptide Y receptor binding

[Term]
id: GO:0031846
name: neurotensin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a neurotensin receptor." [GOC:mah, GOC:nln]
synonym: "neurotensin receptor ligand" NARROW []
is_a: GO:0071855 ! neuropeptide receptor binding

[Term]
id: GO:0031847
name: type 1 neurotensin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 1 neurotensin receptor." [GOC:mah, GOC:nln]
synonym: "type 1 neurotensin receptor ligand" NARROW []
is_a: GO:0031846 ! neurotensin receptor binding

[Term]
id: GO:0031848
name: protection from non-homologous end joining at telomere
namespace: biological_process
def: "A process that prevents non-homologous end joining at telomere, thereby ensuring that telomeres do not fuse." [GOC:mah]
synonym: "protection from NHEJ-mediated telomere fusion" EXACT []
is_a: GO:0043247 ! telomere maintenance in response to DNA damage
relationship: part_of GO:0016233 ! telomere capping

[Term]
id: GO:0031849
name: olfactory receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an olfactory receptor." [GOC:mah, GOC:nln]
synonym: "olfactory receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein coupled receptor binding

[Term]
id: GO:0031850
name: delta-type opioid receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a delta-type opioid receptor." [GOC:mah, GOC:nln]
synonym: "delta-type opioid receptor ligand" NARROW []
synonym: "enkephalin receptor binding" RELATED [GOC:sl]
is_a: GO:0031628 ! opioid receptor binding

[Term]
id: GO:0031851
name: kappa-type opioid receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a kappa-type opioid receptor." [GOC:mah, GOC:nln]
synonym: "dynorphin receptor binding" RELATED []
synonym: "kappa-type opioid receptor ligand" NARROW [GOC:sl]
is_a: GO:0031628 ! opioid receptor binding

[Term]
id: GO:0031852
name: mu-type opioid receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a mu-type opioid receptor." [GOC:mah, GOC:nln, GOC:sl]
synonym: "morphine receptor binding" RELATED [GOC:sl]
synonym: "mu-type opioid receptor ligand" NARROW []
is_a: GO:0031628 ! opioid receptor binding

[Term]
id: GO:0031853
name: nociceptin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a nociceptin receptor." [GOC:mah, GOC:nln]
synonym: "nociceptin receptor ligand" NARROW []
is_a: GO:0031628 ! opioid receptor binding

[Term]
id: GO:0031854
name: orexigenic neuropeptide QRFP receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an orexigenic neuropeptide QRFP receptor." [GOC:mah, GOC:nln]
synonym: "orexigenic neuropeptide QRFP receptor ligand" NARROW []
is_a: GO:0071855 ! neuropeptide receptor binding

[Term]
id: GO:0031855
name: oxytocin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an oxytocin receptor." [GOC:mah, GOC:nln]
synonym: "oxytocin receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein coupled receptor binding

[Term]
id: GO:0031856
name: parathyroid hormone receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a parathyroid hormone receptor." [GOC:mah, GOC:nln]
synonym: "parathyroid hormone receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein coupled receptor binding

[Term]
id: GO:0031857
name: type 1 parathyroid hormone receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 1 parathyroid hormone receptor." [GOC:mah, GOC:nln]
synonym: "type 1 parathyroid hormone receptor ligand" NARROW []
is_a: GO:0031856 ! parathyroid hormone receptor binding

[Term]
id: GO:0031858
name: pituitary adenylate cyclase-activating polypeptide receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a pituitary adenylate cyclase-activating polypeptide receptor." [GOC:mah, GOC:nln]
synonym: "PACAP receptor binding" EXACT []
synonym: "pituitary adenylate cyclase activating peptide receptor binding" EXACT [GOC:dph, GOC:tb]
synonym: "pituitary adenylate cyclase-activating peptide receptor ligand" NARROW []
is_a: GO:0071855 ! neuropeptide receptor binding

[Term]
id: GO:0031859
name: platelet activating factor receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a platelet activating factor receptor." [GOC:mah, GOC:nln]
synonym: "platelet activating factor receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein coupled receptor binding

[Term]
id: GO:0031860
name: telomeric 3' overhang formation
namespace: biological_process
def: "The formation of the single stranded telomeric 3' overhang, a conserved feature that ranges in length from 12 nt in budding yeast to approximately 500 nt in humans." [PMID:16096639]
synonym: "telomere 3'-end processing" EXACT [GOC:mah, GOC:vw]
synonym: "telomere end processing" RELATED [GOC:mah, GOC:vw]
is_a: GO:0022616 ! DNA strand elongation
relationship: part_of GO:0016233 ! telomere capping

[Term]
id: GO:0031861
name: prolactin-releasing peptide receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a prolactin-releasing peptide receptor." [GOC:mah, GOC:nln]
synonym: "prolactin-releasing peptide receptor ligand" NARROW []
is_a: GO:0071855 ! neuropeptide receptor binding

[Term]
id: GO:0031862
name: prostanoid receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a prostanoid receptor." [GOC:mah, GOC:nln]
synonym: "prostanoid receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein coupled receptor binding

[Term]
id: GO:0031863
name: prostaglandin D2 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a prostaglandin D2 receptor." [GOC:mah, GOC:nln]
synonym: "prostaglandin D2 receptor ligand" NARROW []
synonym: "prostanoid DP receptor binding" EXACT []
is_a: GO:0031862 ! prostanoid receptor binding

[Term]
id: GO:0031864
name: EP1 subtype prostaglandin E2 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an EP1 subtype prostaglandin E2 receptor." [GOC:mah, GOC:nln]
synonym: "EP1 subtype prostaglandin E2 receptor ligand" NARROW []
synonym: "prostanoid EP1 receptor binding" EXACT []
is_a: GO:0031862 ! prostanoid receptor binding

[Term]
id: GO:0031865
name: EP2 subtype prostaglandin E2 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an EP2 subtype prostaglandin E2 receptor." [GOC:mah, GOC:nln]
synonym: "EP2 subtype prostaglandin E2 receptor ligand" NARROW []
synonym: "prostanoid EP2 receptor binding" EXACT []
is_a: GO:0031862 ! prostanoid receptor binding

[Term]
id: GO:0031866
name: EP3 subtype prostaglandin E2 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an EP3 subtype prostaglandin E2 receptor." [GOC:mah, GOC:nln]
synonym: "EP3 subtype prostaglandin E2 receptor ligand" NARROW []
synonym: "prostanoid EP3 receptor binding" EXACT []
is_a: GO:0031862 ! prostanoid receptor binding

[Term]
id: GO:0031867
name: EP4 subtype prostaglandin E2 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an EP4 subtype prostaglandin E2 receptor." [GOC:mah, GOC:nln]
synonym: "EP4 subtype prostaglandin E2 receptor ligand" NARROW []
synonym: "prostanoid EP4 receptor binding" EXACT []
is_a: GO:0031862 ! prostanoid receptor binding

[Term]
id: GO:0031868
name: prostaglandin F2-alpha receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a prostaglandin F2-alpha receptor." [GOC:mah, GOC:nln]
synonym: "prostaglandin F2-alpha receptor ligand" NARROW []
synonym: "prostanoid FP receptor binding" EXACT []
is_a: GO:0031862 ! prostanoid receptor binding

[Term]
id: GO:0031869
name: prostacyclin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a prostacyclin receptor." [GOC:mah, GOC:nln]
synonym: "prostacyclin receptor ligand" NARROW []
synonym: "prostanoid IP receptor binding" EXACT []
is_a: GO:0031862 ! prostanoid receptor binding

[Term]
id: GO:0031870
name: thromboxane A2 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a thromboxane A2 receptor." [GOC:mah, GOC:nln]
synonym: "prostanoid TP receptor binding" EXACT []
synonym: "thromboxane A2 receptor ligand" NARROW []
is_a: GO:0031862 ! prostanoid receptor binding

[Term]
id: GO:0031871
name: proteinase activated receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a proteinase activated receptor." [GOC:mah, GOC:nln]
synonym: "proteinase activated receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein coupled receptor binding

[Term]
id: GO:0031872
name: type 1 proteinase activated receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 1 proteinase activated receptor." [GOC:mah, GOC:nln]
synonym: "thrombin receptor binding" EXACT []
synonym: "type 1 proteinase activated receptor ligand" NARROW []
is_a: GO:0031871 ! proteinase activated receptor binding

[Term]
id: GO:0031873
name: type 2 proteinase activated receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 2 proteinase activated receptor." [GOC:mah, GOC:nln]
synonym: "type 2 proteinase activated receptor ligand" NARROW []
is_a: GO:0031871 ! proteinase activated receptor binding

[Term]
id: GO:0031874
name: type 3 proteinase activated receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 3 proteinase activated receptor." [GOC:mah, GOC:nln]
synonym: "type 3 proteinase activated receptor ligand" NARROW []
is_a: GO:0031871 ! proteinase activated receptor binding

[Term]
id: GO:0031875
name: type 4 proteinase activated receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 4 proteinase activated receptor." [GOC:mah, GOC:nln]
synonym: "type 4 proteinase activated receptor ligand" NARROW []
is_a: GO:0031871 ! proteinase activated receptor binding

[Term]
id: GO:0031876
name: secretin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a secretin receptor." [GOC:mah, GOC:nln]
synonym: "secretin receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein coupled receptor binding

[Term]
id: GO:0031877
name: somatostatin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a somatostatin receptor." [GOC:mah, GOC:nln]
synonym: "somatostatin receptor ligand" NARROW []
is_a: GO:0071855 ! neuropeptide receptor binding

[Term]
id: GO:0031878
name: type 1 somatostatin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 1 somatostatin receptor." [GOC:mah, GOC:nln]
synonym: "type 1 somatostatin receptor ligand" NARROW []
is_a: GO:0031877 ! somatostatin receptor binding

[Term]
id: GO:0031879
name: type 2 somatostatin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 2 somatostatin receptor." [GOC:mah, GOC:nln]
synonym: "type 2 somatostatin receptor ligand" NARROW []
is_a: GO:0031877 ! somatostatin receptor binding

[Term]
id: GO:0031880
name: type 3 somatostatin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 3 somatostatin receptor." [GOC:mah, GOC:nln]
synonym: "type 3 somatostatin receptor ligand" NARROW []
is_a: GO:0031877 ! somatostatin receptor binding

[Term]
id: GO:0031881
name: type 4 somatostatin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 4 somatostatin receptor." [GOC:mah, GOC:nln]
synonym: "type 4 somatostatin receptor ligand" NARROW []
is_a: GO:0031877 ! somatostatin receptor binding

[Term]
id: GO:0031882
name: type 5 somatostatin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 5 somatostatin receptor." [GOC:mah, GOC:nln]
synonym: "type 5 somatostatin receptor ligand" NARROW []
is_a: GO:0031877 ! somatostatin receptor binding

[Term]
id: GO:0031883
name: taste receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a taste receptor." [GOC:mah, GOC:nln]
synonym: "taste receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein coupled receptor binding

[Term]
id: GO:0031884
name: type 1 member 1 taste receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 1 member 1 taste receptor." [GOC:mah, GOC:nln]
synonym: "type 1 member 1 taste receptor ligand" NARROW []
is_a: GO:0031883 ! taste receptor binding

[Term]
id: GO:0031885
name: type 1 member 2 taste receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 1 member 2 taste receptor." [GOC:mah, GOC:nln]
synonym: "type 1 member 2 taste receptor ligand" NARROW []
is_a: GO:0031883 ! taste receptor binding

[Term]
id: GO:0031886
name: type 1 member 3 taste receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 1 member 3 taste receptor." [GOC:mah, GOC:nln]
synonym: "sweet taste receptor binding" EXACT []
synonym: "type 1 member 3 taste receptor ligand" NARROW []
is_a: GO:0031883 ! taste receptor binding

[Term]
id: GO:0031887
name: lipid particle transport along microtubule
namespace: biological_process
def: "The directed movement of a lipid particle along a microtubule, mediated by motor proteins." [PMID:9491895]
is_a: GO:0072384 ! organelle transport along microtubule

[Term]
id: GO:0031889
name: urotensin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a urotensin receptor." [GOC:mah, GOC:nln]
synonym: "urotensin receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein coupled receptor binding

[Term]
id: GO:0031890
name: vasoactive intestinal polypeptide receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a vasoactive intestinal polypeptide receptor." [GOC:mah, GOC:nln]
synonym: "vasoactive intestinal polypeptide receptor ligand" NARROW []
synonym: "VIP receptor binding" EXACT []
is_a: GO:0071855 ! neuropeptide receptor binding

[Term]
id: GO:0031891
name: type 1 vasoactive intestinal polypeptide receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 1 vasoactive intestinal polypeptide receptor." [GOC:mah, GOC:nln]
synonym: "type 1 vasoactive intestinal polypeptide receptor ligand" NARROW []
synonym: "type 2 PACAP receptor binding" EXACT []
is_a: GO:0031890 ! vasoactive intestinal polypeptide receptor binding

[Term]
id: GO:0031892
name: type 2 vasoactive intestinal polypeptide receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 2 vasoactive intestinal polypeptide receptor." [GOC:mah, GOC:nln]
synonym: "type 2 vasoactive intestinal polypeptide receptor ligand" NARROW []
synonym: "type 3 PACAP receptor binding" EXACT []
is_a: GO:0031890 ! vasoactive intestinal polypeptide receptor binding

[Term]
id: GO:0031893
name: vasopressin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a vasopressin receptor." [GOC:mah, GOC:nln]
synonym: "vasopressin receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein coupled receptor binding

[Term]
id: GO:0031894
name: V1A vasopressin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a V1A vasopressin receptor." [GOC:mah, GOC:nln]
synonym: "V1A vasopressin receptor ligand" NARROW []
is_a: GO:0031893 ! vasopressin receptor binding

[Term]
id: GO:0031895
name: V1B vasopressin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a V1B vasopressin receptor." [GOC:mah, GOC:nln]
synonym: "V1B vasopressin receptor ligand" NARROW []
is_a: GO:0031893 ! vasopressin receptor binding

[Term]
id: GO:0031896
name: V2 vasopressin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a V2 vasopressin receptor." [GOC:mah, GOC:nln]
synonym: "V2 vasopressin receptor ligand" NARROW []
is_a: GO:0031893 ! vasopressin receptor binding

[Term]
id: GO:0031897
name: Tic complex
namespace: cellular_component
def: "The translocon of the inner envelope of chloroplasts, which facilitates the import of proteins across the chloroplast inner membrane." [PMID:12180471, PMID:12393016]
synonym: "chloroplast inner membrane translocase complex" EXACT []
is_a: GO:0044434 ! chloroplast part
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0009706 ! chloroplast inner membrane

[Term]
id: GO:0031898
name: chromoplast envelope
namespace: cellular_component
def: "The double lipid bilayer enclosing the chromoplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:pz]
is_a: GO:0009526 ! plastid envelope
relationship: part_of GO:0009509 ! chromoplast

[Term]
id: GO:0031899
name: chromoplast inner membrane
namespace: cellular_component
def: "The inner, i.e. lumen-facing, lipid bilayer of the chromoplast envelope; also faces the chromoplast stroma." [GOC:pz]
is_a: GO:0009528 ! plastid inner membrane
is_a: GO:0046862 ! chromoplast membrane

[Term]
id: GO:0031900
name: chromoplast outer membrane
namespace: cellular_component
def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the chromoplast envelope." [GOC:pz]
is_a: GO:0009527 ! plastid outer membrane
is_a: GO:0046862 ! chromoplast membrane

[Term]
id: GO:0031901
name: early endosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding an early endosome." [GOC:pz]
is_a: GO:0010008 ! endosome membrane
relationship: part_of GO:0005769 ! early endosome

[Term]
id: GO:0031902
name: late endosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a late endosome." [GOC:pz]
is_a: GO:0010008 ! endosome membrane
relationship: part_of GO:0005770 ! late endosome

[Term]
id: GO:0031903
name: microbody membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a microbody." [GOC:mah]
is_a: GO:0042579 ! microbody
is_a: GO:0044438 ! microbody part
is_a: GO:0098588 ! bounding membrane of organelle
is_a: GO:0098805 ! whole membrane

[Term]
id: GO:0031904
name: endosome lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of an endosome." [GOC:mah]
xref: NIF_Subcellular:sao1547508851
is_a: GO:0005775 ! vacuolar lumen
is_a: GO:0044440 ! endosomal part

[Term]
id: GO:0031905
name: early endosome lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of an early endosome." [GOC:mah]
is_a: GO:0031904 ! endosome lumen
relationship: part_of GO:0005769 ! early endosome

[Term]
id: GO:0031906
name: late endosome lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of a late endosome." [GOC:mah]
is_a: GO:0031904 ! endosome lumen
relationship: part_of GO:0005770 ! late endosome

[Term]
id: GO:0031907
name: microbody lumen
namespace: cellular_component
def: "The volume enclosed by the membranes of a microbody." [GOC:mah]
is_a: GO:0044438 ! microbody part
is_a: GO:0070013 ! intracellular organelle lumen

[Term]
id: GO:0031908
name: glyoxysomal lumen
namespace: cellular_component
def: "The volume enclosed by the membranes of a glyoxysome." [GOC:mah]
is_a: GO:0005782 ! peroxisomal matrix

[Term]
id: GO:0031910
name: cytostome
namespace: cellular_component
def: "Stable, specialized structure for the ingestion of food by the cell into phagosomes." [PMID:10503189]
xref: Wikipedia:Cytostome
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0031911
name: cytoproct
namespace: cellular_component
def: "Stable, specialized structure for extrusion of waste by the cell into the surrounding medium." [PMID:10503189]
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0031912
name: oral apparatus
namespace: cellular_component
def: "Complex basket- or funnel-like structure used by the cell to collect food and channel it to the cytostome; includes specialized sub-structures made up of closely-spaced cilia and underlying basal bodies and fibrillar systems." [PMID:10503189]
comment: Note that this term refers to a subcellular structure characteristic of ciliate protozoans, and should not be confused with oral anatomical structures of multicellular animals.
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0031913
name: contractile vacuole pore
namespace: cellular_component
def: "Stable structure that regulates the flow of liquid between the contractile vacuole and the surrounding medium." [PMID:10503189]
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044433 ! cytoplasmic vesicle part
is_a: GO:0044437 ! vacuolar part
is_a: GO:0098797 ! plasma membrane protein complex
relationship: part_of GO:0031164 ! contractile vacuolar membrane

[Term]
id: GO:0031914
name: negative regulation of synaptic plasticity
namespace: biological_process
def: "A process that decreases synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:mah]
synonym: "down regulation of synaptic plasticity" EXACT []
synonym: "down-regulation of synaptic plasticity" EXACT []
synonym: "downregulation of synaptic plasticity" EXACT []
synonym: "inhibition of synaptic plasticity" NARROW []
is_a: GO:0048167 ! regulation of synaptic plasticity

[Term]
id: GO:0031915
name: positive regulation of synaptic plasticity
namespace: biological_process
def: "A process that increases synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:mah]
synonym: "activation of synaptic plasticity" NARROW []
synonym: "stimulation of synaptic plasticity" NARROW []
synonym: "up regulation of synaptic plasticity" EXACT []
synonym: "up-regulation of synaptic plasticity" EXACT []
synonym: "upregulation of synaptic plasticity" EXACT []
is_a: GO:0048167 ! regulation of synaptic plasticity

[Term]
id: GO:0031916
name: regulation of synaptic metaplasticity
namespace: biological_process
def: "A process that modulates synaptic metaplasticity. Metaplasticity is a higher-order form of plasticity and is manifest as a change in the ability to induce subsequent synaptic plasticity that is the ability of synapses to change as circumstances require." [GOC:mah, PMID:8658594]
is_a: GO:0048167 ! regulation of synaptic plasticity

[Term]
id: GO:0031917
name: negative regulation of synaptic metaplasticity
namespace: biological_process
def: "A process that decreases synaptic metaplasticity. Metaplasticity is a higher-order form of plasticity and is manifest as a change in the ability to induce subsequent synaptic plasticity that is the ability of synapses to change as circumstances require." [GOC:mah, PMID:8658594]
synonym: "down regulation of synaptic metaplasticity" EXACT []
synonym: "down-regulation of synaptic metaplasticity" EXACT []
synonym: "downregulation of synaptic metaplasticity" EXACT []
synonym: "inhibition of synaptic metaplasticity" NARROW []
is_a: GO:0031914 ! negative regulation of synaptic plasticity
is_a: GO:0031916 ! regulation of synaptic metaplasticity

[Term]
id: GO:0031918
name: positive regulation of synaptic metaplasticity
namespace: biological_process
def: "A process that increases synaptic metaplasticity. Metaplasticity is a higher-order form of plasticity and is manifest as a change in the ability to induce subsequent synaptic plasticity that is the ability of synapses to change as circumstances require." [GOC:mah, PMID:8658594]
synonym: "activation of synaptic metaplasticity" NARROW []
synonym: "stimulation of synaptic metaplasticity" NARROW []
synonym: "up regulation of synaptic metaplasticity" EXACT []
synonym: "up-regulation of synaptic metaplasticity" EXACT []
synonym: "upregulation of synaptic metaplasticity" EXACT []
is_a: GO:0031915 ! positive regulation of synaptic plasticity
is_a: GO:0031916 ! regulation of synaptic metaplasticity

[Term]
id: GO:0031919
name: vitamin B6 transport
namespace: biological_process
def: "The directed movement of any of the vitamin B6 compounds -- pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate -- into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
is_a: GO:0051180 ! vitamin transport
is_a: GO:0071702 ! organic substance transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0031920
name: pyridoxal transport
namespace: biological_process
def: "The directed movement of pyridoxal into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah]
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0031919 ! vitamin B6 transport

[Term]
id: GO:0031921
name: pyridoxal phosphate transport
namespace: biological_process
def: "The directed movement of pyridoxal phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore; pyridoxal phosphate is pyridoxal phosphorylated at the hydroxymethyl group of C-5, and is the active form of vitamin B6." [GOC:mah]
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015748 ! organophosphate ester transport
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0031922
name: pyridoxamine transport
namespace: biological_process
def: "The directed movement of pyridoxamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Pyridoxamine, 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah]
is_a: GO:0015695 ! organic cation transport
is_a: GO:0015696 ! ammonium transport
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0031919 ! vitamin B6 transport

[Term]
id: GO:0031923
name: pyridoxine transport
namespace: biological_process
def: "The directed movement of pyridoxine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah]
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0031919 ! vitamin B6 transport

[Term]
id: GO:0031924
name: vitamin B6 transporter activity
namespace: molecular_function
def: "Enables the directed movement of any of the vitamin B6 compounds -- pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate -- into, out of or within a cell, or between cells." [GOC:mah]
is_a: GO:0051183 ! vitamin transporter activity
relationship: part_of GO:0031919 ! vitamin B6 transport

[Term]
id: GO:0031925
name: pyridoxal transmembrane transporter activity
namespace: molecular_function
def: "Enables the directed movement of pyridoxal across a membrane into, out of or within a cell, or between cells. Pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah]
synonym: "pyridoxal transporter activity" BROAD []
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity
is_a: GO:0031924 ! vitamin B6 transporter activity
is_a: GO:0090482 ! vitamin transmembrane transporter activity
is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity
relationship: part_of GO:1903090 ! pyridoxal transmembrane transport

[Term]
id: GO:0031926
name: pyridoxal phosphate transmembrane transporter activity
namespace: molecular_function
def: "Enables the directed movement of pyridoxal phosphate into, out of or within a cell, or between cells; pyridoxal phosphate is pyridoxal phosphorylated at the hydroxymethyl group of C-5, and is the active form of vitamin B6." [GOC:mah]
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity
is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity

[Term]
id: GO:0031927
name: pyridoxamine transmembrane transporter activity
namespace: molecular_function
def: "Enables the directed movement of pyridoxamine into, out of or within a cell, or between cells. Pyridoxamine, 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah]
is_a: GO:0008519 ! ammonium transmembrane transporter activity
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:0031924 ! vitamin B6 transporter activity
is_a: GO:0090482 ! vitamin transmembrane transporter activity
is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity
relationship: part_of GO:1903091 ! pyridoxamine transmembrane transport

[Term]
id: GO:0031928
name: pyridoxine transmembrane transporter activity
namespace: molecular_function
def: "Enables the directed movement of pyridoxine across a membrane into, out of or within a cell, or between cells. Pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah]
synonym: "pyridoxine transporter activity" BROAD []
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity
is_a: GO:0031924 ! vitamin B6 transporter activity
is_a: GO:0090482 ! vitamin transmembrane transporter activity
is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity
relationship: part_of GO:1903092 ! pyridoxine transmembrane transport

[Term]
id: GO:0031929
name: TOR signaling
namespace: biological_process
def: "A series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors." [PMID:12372295]
comment: Note that this term should not be confused with 'torso signaling pathway ; GO:0008293', although torso is abbreviated 'tor'.
synonym: "target of rapamycin signaling pathway" EXACT []
synonym: "target of rapamycin signalling pathway" EXACT []
synonym: "TOR signal transduction" EXACT [GOC:signaling]
synonym: "TOR signaling cascade" RELATED [GOC:signaling]
synonym: "TOR signaling pathway" EXACT []
synonym: "TOR signalling pathway" EXACT []
is_a: GO:0035556 ! intracellular signal transduction

[Term]
id: GO:0031930
name: mitochondria-nucleus signaling pathway
namespace: biological_process
def: "A series of molecular signals that forms a pathway of communication from the mitochondria to the nucleus and initiates cellular changes in response to changes in mitochondrial function." [GOC:jh, PMID:15068799]
synonym: "mitochondria-nucleus signal transduction" EXACT [GOC:signaling]
synonym: "mitochondrial signaling pathway" EXACT []
synonym: "mitochondrial signalling pathway" EXACT []
synonym: "retrograde response" EXACT []
is_a: GO:0007165 ! signal transduction

[Term]
id: GO:0031931
name: TORC1 complex
namespace: cellular_component
def: "A protein complex that contains at least TOR (target of rapamycin) and Raptor (regulatory-associated protein of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of S6K. In Saccharomyces, the complex contains Kog1p, Lst8p, Tco89p, and either Tor1p or Tor2p." [GOC:jh, PMID:15780592, PMID:16469695, PMID:21548787]
synonym: "dTOR/dRaptor complex" NARROW [PMID:17183368]
synonym: "dTORC1" NARROW [PMID:17183368]
synonym: "mTORC1" NARROW [PMID:18765678, PMID:21548787]
synonym: "nutrient sensitive complex" EXACT []
synonym: "rapamycin and nutrient-sensitive TOR complex" EXACT [PMID:21548787]
synonym: "TOR complex 1" EXACT []
synonym: "TORC 1 complex" EXACT []
synonym: "TORC1" EXACT [PMID:21548787]
xref: Wikipedia:MTORC1
is_a: GO:0038201 ! TOR complex
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0031932
name: TORC2 complex
namespace: cellular_component
def: "A protein complex that contains at least TOR (target of rapamycin) and Rictor (rapamycin-insensitive companion of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of PKB (also called AKT). In Saccharomyces, the complex contains Avo1p, Avo2p, Tsc11p, Lst8p, Bit61p, Slm1p, Slm2p, and Tor2p." [GOC:bf, GOC:jh, PMID:14736892, PMID:15780592, PMID:16469695, PMID:21548787]
synonym: "mTORC2" NARROW [PMID:20496258, PMID:21548787]
synonym: "rapamycin and nutrient-insensitive TOR complex" EXACT [PMID:21548787]
synonym: "TOR complex 2" EXACT []
synonym: "TORC 2 complex" EXACT []
synonym: "TORC2" EXACT [PMID:21548787]
xref: Wikipedia:MTORC1
is_a: GO:0038201 ! TOR complex
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0031933
name: telomeric heterochromatin
namespace: cellular_component
def: "Heterochromatic regions of the chromosome found at the telomeres." [GOC:mah]
synonym: "telomeric chromatin" BROAD [GOC:pr]
is_a: GO:0000792 ! heterochromatin
intersection_of: GO:0000792 ! heterochromatin
intersection_of: part_of GO:0000781 ! chromosome, telomeric region
relationship: part_of GO:0000781 ! chromosome, telomeric region

[Term]
id: GO:0031934
name: mating-type region heterochromatin
namespace: cellular_component
def: "Heterochromatic regions of the chromosome found at silenced mating-type loci." [GOC:mah]
is_a: GO:0000792 ! heterochromatin

[Term]
id: GO:0031935
name: regulation of chromatin silencing
namespace: biological_process
def: "Any process that affects the rate, extent or location of chromatin silencing." [GOC:mah]
synonym: "regulation of heterochromatic silencing" RELATED []
is_a: GO:0006355 ! regulation of transcription, DNA-templated
is_a: GO:0060968 ! regulation of gene silencing
is_a: GO:1903308 ! regulation of chromatin modification
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006342 ! chromatin silencing
relationship: regulates GO:0006342 ! chromatin silencing

[Term]
id: GO:0031936
name: negative regulation of chromatin silencing
namespace: biological_process
alt_id: GO:0006345
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chromatin silencing." [GOC:mah]
synonym: "down regulation of chromatin silencing" EXACT []
synonym: "down-regulation of chromatin silencing" EXACT []
synonym: "downregulation of chromatin silencing" EXACT []
synonym: "inhibition of chromatin silencing" NARROW []
synonym: "loss of chromatin silencing" EXACT []
synonym: "negative regulation of heterochromatic silencing" EXACT []
is_a: GO:0031935 ! regulation of chromatin silencing
is_a: GO:0045815 ! positive regulation of gene expression, epigenetic
is_a: GO:0045893 ! positive regulation of transcription, DNA-templated
is_a: GO:0060969 ! negative regulation of gene silencing
is_a: GO:1903309 ! negative regulation of chromatin modification
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006342 ! chromatin silencing
relationship: negatively_regulates GO:0006342 ! chromatin silencing

[Term]
id: GO:0031937
name: positive regulation of chromatin silencing
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chromatin silencing." [GOC:mah]
synonym: "activation of chromatin silencing" NARROW []
synonym: "positive regulation of heterochromatic silencing" EXACT []
synonym: "stimulation of chromatin silencing" NARROW []
synonym: "up regulation of chromatin silencing" EXACT []
synonym: "up-regulation of chromatin silencing" EXACT []
synonym: "upregulation of chromatin silencing" EXACT []
is_a: GO:0031935 ! regulation of chromatin silencing
is_a: GO:1903310 ! positive regulation of chromatin modification
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006342 ! chromatin silencing
relationship: positively_regulates GO:0006342 ! chromatin silencing

[Term]
id: GO:0031938
name: regulation of chromatin silencing at telomere
namespace: biological_process
def: "Any process that affects the rate, extent or location of chromatin silencing at telomeres." [GOC:mah]
synonym: "regulation of heterochromatic silencing at telomere" EXACT []
is_a: GO:0031935 ! regulation of chromatin silencing
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006348 ! chromatin silencing at telomere
relationship: regulates GO:0006348 ! chromatin silencing at telomere

[Term]
id: GO:0031939
name: negative regulation of chromatin silencing at telomere
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chromatin silencing at telomeres." [GOC:mah]
synonym: "down regulation of chromatin silencing at telomere" EXACT []
synonym: "down-regulation of chromatin silencing at telomere" EXACT []
synonym: "downregulation of chromatin silencing at telomere" EXACT []
synonym: "inhibition of chromatin silencing at telomere" NARROW []
synonym: "negative regulation of heterochromatic silencing at telomere" EXACT []
is_a: GO:0031936 ! negative regulation of chromatin silencing
is_a: GO:0031938 ! regulation of chromatin silencing at telomere
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006348 ! chromatin silencing at telomere
relationship: negatively_regulates GO:0006348 ! chromatin silencing at telomere

[Term]
id: GO:0031940
name: positive regulation of chromatin silencing at telomere
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chromatin silencing at telomeres." [GOC:mah]
synonym: "activation of chromatin silencing at telomere" NARROW []
synonym: "positive regulation of heterochromatic silencing at telomere" EXACT []
synonym: "stimulation of chromatin silencing at telomere" NARROW []
synonym: "up regulation of chromatin silencing at telomere" EXACT []
synonym: "up-regulation of chromatin silencing at telomere" EXACT []
synonym: "upregulation of chromatin silencing at telomere" EXACT []
is_a: GO:0031937 ! positive regulation of chromatin silencing
is_a: GO:0031938 ! regulation of chromatin silencing at telomere
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006348 ! chromatin silencing at telomere
relationship: positively_regulates GO:0006348 ! chromatin silencing at telomere

[Term]
id: GO:0031941
name: filamentous actin
namespace: cellular_component
def: "A two-stranded helical polymer of the protein actin." [GOC:mah]
comment: Note that this term refers only to the actin portion of a microfilament, and does not encompass associated proteins. See also the cellular component term 'actin filament ; GO:0005884'.
synonym: "F-actin" EXACT []
xref: Wikipedia:Actin
is_a: GO:0043234 ! protein complex
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0005884 ! actin filament

[Term]
id: GO:0031942
name: i-AAA complex
namespace: cellular_component
def: "Protease complex of the mitochondrial inner membrane whose catalytic residues lie on the intermembrane space side of the inner membrane; involved in mitochondrial protein turnover. Contains a subunit belonging to the AAA family of ATP-dependent metalloproteases." [PMID:16247555, PMID:16267274]
is_a: GO:0098800 ! inner mitochondrial membrane protein complex
relationship: part_of GO:0005743 ! mitochondrial inner membrane

[Term]
id: GO:0031943
name: regulation of glucocorticoid metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids." [GOC:mah]
synonym: "regulation of glucocorticoid metabolism" EXACT []
is_a: GO:0019218 ! regulation of steroid metabolic process
is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:0032350 ! regulation of hormone metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008211 ! glucocorticoid metabolic process
relationship: regulates GO:0008211 ! glucocorticoid metabolic process

[Term]
id: GO:0031944
name: negative regulation of glucocorticoid metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids." [GOC:mah]
synonym: "down regulation of glucocorticoid metabolic process" EXACT []
synonym: "down-regulation of glucocorticoid metabolic process" EXACT []
synonym: "downregulation of glucocorticoid metabolic process" EXACT []
synonym: "inhibition of glucocorticoid metabolic process" NARROW []
synonym: "negative regulation of glucocorticoid metabolism" EXACT []
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0031943 ! regulation of glucocorticoid metabolic process
is_a: GO:0032351 ! negative regulation of hormone metabolic process
is_a: GO:0045939 ! negative regulation of steroid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008211 ! glucocorticoid metabolic process
relationship: negatively_regulates GO:0008211 ! glucocorticoid metabolic process

[Term]
id: GO:0031945
name: positive regulation of glucocorticoid metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids." [GOC:mah]
synonym: "activation of glucocorticoid metabolic process" NARROW []
synonym: "positive regulation of glucocorticoid metabolism" EXACT []
synonym: "stimulation of glucocorticoid metabolic process" NARROW []
synonym: "up regulation of glucocorticoid metabolic process" EXACT []
synonym: "up-regulation of glucocorticoid metabolic process" EXACT []
synonym: "upregulation of glucocorticoid metabolic process" EXACT []
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0031943 ! regulation of glucocorticoid metabolic process
is_a: GO:0032352 ! positive regulation of hormone metabolic process
is_a: GO:0045940 ! positive regulation of steroid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008211 ! glucocorticoid metabolic process
relationship: positively_regulates GO:0008211 ! glucocorticoid metabolic process

[Term]
id: GO:0031946
name: regulation of glucocorticoid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids." [GOC:mah]
is_a: GO:0031943 ! regulation of glucocorticoid metabolic process
is_a: GO:0090030 ! regulation of steroid hormone biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006704 ! glucocorticoid biosynthetic process
relationship: regulates GO:0006704 ! glucocorticoid biosynthetic process

[Term]
id: GO:0031947
name: negative regulation of glucocorticoid biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids." [GOC:mah]
synonym: "down regulation of glucocorticoid biosynthetic process" EXACT []
synonym: "down-regulation of glucocorticoid biosynthetic process" EXACT []
synonym: "downregulation of glucocorticoid biosynthetic process" EXACT []
synonym: "inhibition of glucocorticoid biosynthetic process" NARROW []
is_a: GO:0031944 ! negative regulation of glucocorticoid metabolic process
is_a: GO:0031946 ! regulation of glucocorticoid biosynthetic process
is_a: GO:0090032 ! negative regulation of steroid hormone biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006704 ! glucocorticoid biosynthetic process
relationship: negatively_regulates GO:0006704 ! glucocorticoid biosynthetic process

[Term]
id: GO:0031948
name: positive regulation of glucocorticoid biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids." [GOC:mah]
synonym: "activation of glucocorticoid biosynthetic process" NARROW []
synonym: "stimulation of glucocorticoid biosynthetic process" NARROW []
synonym: "up regulation of glucocorticoid biosynthetic process" EXACT []
synonym: "up-regulation of glucocorticoid biosynthetic process" EXACT []
synonym: "upregulation of glucocorticoid biosynthetic process" EXACT []
is_a: GO:0031945 ! positive regulation of glucocorticoid metabolic process
is_a: GO:0031946 ! regulation of glucocorticoid biosynthetic process
is_a: GO:0090031 ! positive regulation of steroid hormone biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006704 ! glucocorticoid biosynthetic process
relationship: positively_regulates GO:0006704 ! glucocorticoid biosynthetic process

[Term]
id: GO:0031949
name: regulation of glucocorticoid catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids." [GOC:mah]
is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:0031943 ! regulation of glucocorticoid metabolic process
is_a: GO:0050994 ! regulation of lipid catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006713 ! glucocorticoid catabolic process
relationship: regulates GO:0006713 ! glucocorticoid catabolic process

[Term]
id: GO:0031950
name: negative regulation of glucocorticoid catabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids." [GOC:mah]
synonym: "down regulation of glucocorticoid catabolic process" EXACT []
synonym: "down-regulation of glucocorticoid catabolic process" EXACT []
synonym: "downregulation of glucocorticoid catabolic process" EXACT []
synonym: "inhibition of glucocorticoid catabolic process" NARROW []
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:0031944 ! negative regulation of glucocorticoid metabolic process
is_a: GO:0031949 ! regulation of glucocorticoid catabolic process
is_a: GO:0050995 ! negative regulation of lipid catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006713 ! glucocorticoid catabolic process
relationship: negatively_regulates GO:0006713 ! glucocorticoid catabolic process

[Term]
id: GO:0031951
name: positive regulation of glucocorticoid catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids." [GOC:mah]
synonym: "activation of glucocorticoid catabolic process" NARROW []
synonym: "stimulation of glucocorticoid catabolic process" NARROW []
synonym: "up regulation of glucocorticoid catabolic process" EXACT []
synonym: "up-regulation of glucocorticoid catabolic process" EXACT []
synonym: "upregulation of glucocorticoid catabolic process" EXACT []
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:0031945 ! positive regulation of glucocorticoid metabolic process
is_a: GO:0031949 ! regulation of glucocorticoid catabolic process
is_a: GO:0050996 ! positive regulation of lipid catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006713 ! glucocorticoid catabolic process
relationship: positively_regulates GO:0006713 ! glucocorticoid catabolic process

[Term]
id: GO:0031952
name: regulation of protein autophosphorylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of addition of the phosphorylation by a protein of one or more of its own residues." [GOC:mah]
synonym: "regulation of protein amino acid autophosphorylation" EXACT [GOC:bf]
is_a: GO:0001932 ! regulation of protein phosphorylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0046777 ! protein autophosphorylation
relationship: has_part GO:0045859 ! regulation of protein kinase activity
relationship: regulates GO:0046777 ! protein autophosphorylation

[Term]
id: GO:0031953
name: negative regulation of protein autophosphorylation
namespace: biological_process
def: "Any process that stops, prevents or decreases the rate of the phosphorylation by a protein of one or more of its own residues." [GOC:mah]
synonym: "down regulation of protein amino acid autophosphorylation" EXACT []
synonym: "down-regulation of protein amino acid autophosphorylation" EXACT []
synonym: "downregulation of protein amino acid autophosphorylation" EXACT []
synonym: "inhibition of protein amino acid autophosphorylation" NARROW []
synonym: "negative regulation of protein amino acid autophosphorylation" EXACT [GOC:bf]
is_a: GO:0001933 ! negative regulation of protein phosphorylation
is_a: GO:0031952 ! regulation of protein autophosphorylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0046777 ! protein autophosphorylation
relationship: has_part GO:0006469 ! negative regulation of protein kinase activity
relationship: negatively_regulates GO:0046777 ! protein autophosphorylation

[Term]
id: GO:0031954
name: positive regulation of protein autophosphorylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the phosphorylation by a protein of one or more of its own residues." [GOC:mah]
synonym: "activation of protein amino acid autophosphorylation" NARROW []
synonym: "positive regulation of protein amino acid autophosphorylation" EXACT [GOC:bf]
synonym: "stimulation of protein amino acid autophosphorylation" NARROW []
synonym: "up regulation of protein amino acid autophosphorylation" EXACT []
synonym: "up-regulation of protein amino acid autophosphorylation" EXACT []
synonym: "upregulation of protein amino acid autophosphorylation" EXACT []
is_a: GO:0001934 ! positive regulation of protein phosphorylation
is_a: GO:0031952 ! regulation of protein autophosphorylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0046777 ! protein autophosphorylation
relationship: has_part GO:0045860 ! positive regulation of protein kinase activity
relationship: positively_regulates GO:0046777 ! protein autophosphorylation

[Term]
id: GO:0031955
name: short-chain fatty acid-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + a short-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; short-chain fatty acids are fatty acids with a chain length of less than C6." [CHEBI:26666, EC:6.2.1.3, GOC:mah]
synonym: "short-chain fatty acid activation" RELATED []
synonym: "short-chain fatty-acid-CoA ligase activity" EXACT [GOC:bf]
synonym: "short-chain-fatty-acid-CoA ligase activity" EXACT []
is_a: GO:0015645 ! fatty acid ligase activity

[Term]
id: GO:0031956
name: medium-chain fatty acid-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + a medium-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; a medium-chain fatty acid is any fatty acid with a chain length of between C6 and C12." [CHEBI:59554, EC:6.2.1.3, GOC:mah]
synonym: "medium-chain fatty acid activation" RELATED []
synonym: "medium-chain fatty-acid-CoA ligase activity" EXACT [GOC:bf]
synonym: "medium-chain-fatty-acid-CoA ligase activity" EXACT []
is_a: GO:0015645 ! fatty acid ligase activity

[Term]
id: GO:0031957
name: very long-chain fatty acid-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + a very-long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; a very long-chain fatty acid is a fatty acid which has a chain length greater than C22." [CHEBI:27283, EC:6.2.1.3, GOC:mah]
synonym: "very-long-chain fatty acid activation" RELATED []
synonym: "very-long-chain fatty acid-CoA ligase activity" EXACT []
synonym: "very-long-chain-fatty-acid-CoA ligase activity" EXACT []
is_a: GO:0015645 ! fatty acid ligase activity

[Term]
id: GO:0031958
name: corticosteroid receptor signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of a corticosteroid binding to its receptor." [GOC:mah, PMID:11027914, PMID:12606724]
synonym: "corticosteroid receptor signalling pathway" EXACT []
is_a: GO:0030518 ! intracellular steroid hormone receptor signaling pathway

[Term]
id: GO:0031959
name: mineralocorticoid receptor signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of a mineralocorticoid binding to its receptor." [GOC:mah, PMID:11027914, PMID:12606724]
synonym: "mineralocorticoid receptor signalling pathway" EXACT []
is_a: GO:0031958 ! corticosteroid receptor signaling pathway

[Term]
id: GO:0031960
name: response to corticosteroid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosteroid hormone stimulus. A corticosteroid is a steroid hormone that is produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. They include glucocorticoids and mineralocorticoids." [GOC:mah, PMID:11027914]
synonym: "response to corticosteroid stimulus" EXACT [GOC:dos]
is_a: GO:0048545 ! response to steroid hormone

[Term]
id: GO:0031961
name: cortisol receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a cortisol receptor." [GOC:mah, PMID:12511169]
is_a: GO:0035259 ! glucocorticoid receptor binding

[Term]
id: GO:0031962
name: mineralocorticoid receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a mineralocorticoid receptor." [GOC:mah, PMID:12511169]
is_a: GO:0035258 ! steroid hormone receptor binding

[Term]
id: GO:0031963
name: cortisol receptor activity
namespace: molecular_function
def: "Combining with cortisol and transmitting the signal within the cell to trigger a change in cell activity or function." [GOC:mah, PMID:12511169]
comment: For cortisol receptors that act in the nucleus to regulate transcription, consider also annotating to the terms: ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity ; GO:0038049' or ligand-activated RNA polymerase II transcription factor binding transcription factor activity ; GO:0038049'.
is_a: GO:0004883 ! glucocorticoid receptor activity

[Term]
id: GO:0031964
name: beta-alanyl-histamine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-beta-alanyl histamine + H2O = histamine + beta-alanine." [GOC:rc, PMID:16299587]
synonym: "carcinine hydrolase activity" EXACT []
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0031965
name: nuclear membrane
namespace: cellular_component
def: "Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:mah, GOC:pz]
xref: NIF_Subcellular:sao1687101204
is_a: GO:0031090 ! organelle membrane
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0005635 ! nuclear envelope

[Term]
id: GO:0031966
name: mitochondrial membrane
namespace: cellular_component
def: "Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829]
xref: NIF_Subcellular:sao1045389829
is_a: GO:0031090 ! organelle membrane
is_a: GO:0044429 ! mitochondrial part
relationship: part_of GO:0005740 ! mitochondrial envelope

[Term]
id: GO:0031967
name: organelle envelope
namespace: cellular_component
def: "A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes." [GOC:mah, GOC:pz]
subset: gosubset_prok
is_a: GO:0031975 ! envelope
is_a: GO:0044446 ! intracellular organelle part
relationship: part_of GO:0043227 ! membrane-bounded organelle

[Term]
id: GO:0031968
name: organelle outer membrane
namespace: cellular_component
def: "The outer, i.e. cytoplasm-facing in a cellular organelle, lipid bilayer of an organelle envelope." [GOC:mah]
is_a: GO:0019867 ! outer membrane
is_a: GO:0044424 ! intracellular part
is_a: GO:0098588 ! bounding membrane of organelle
is_a: GO:0098805 ! whole membrane
relationship: part_of GO:0031967 ! organelle envelope

[Term]
id: GO:0031969
name: chloroplast membrane
namespace: cellular_component
def: "Either of the lipid bilayers that surround a chloroplast and form the chloroplast envelope." [GOC:mah, GOC:pz]
xref: Wikipedia:Chloroplast_membrane
is_a: GO:0042170 ! plastid membrane
is_a: GO:0044434 ! chloroplast part
relationship: part_of GO:0009941 ! chloroplast envelope

[Term]
id: GO:0031970
name: organelle envelope lumen
namespace: cellular_component
def: "The region between the inner and outer lipid bilayers of an organelle envelope." [GOC:mah]
synonym: "organelle intermembrane space" EXACT []
is_a: GO:0031974 ! membrane-enclosed lumen
is_a: GO:0044446 ! intracellular organelle part
relationship: part_of GO:0031967 ! organelle envelope

[Term]
id: GO:0031972
name: chloroplast intermembrane space
namespace: cellular_component
def: "The region between the inner and outer lipid bilayers of a chloroplast envelope." [GOC:mah]
synonym: "chloroplast envelope lumen" EXACT []
is_a: GO:0009529 ! plastid intermembrane space
is_a: GO:0044434 ! chloroplast part
relationship: part_of GO:0009941 ! chloroplast envelope

[Term]
id: GO:0031973
name: chromoplast intermembrane space
namespace: cellular_component
def: "The region between the inner and outer lipid bilayers of a chromoplast envelope." [GOC:mah]
synonym: "chromoplast envelope lumen" EXACT []
is_a: GO:0009529 ! plastid intermembrane space
relationship: part_of GO:0031898 ! chromoplast envelope

[Term]
id: GO:0031974
name: membrane-enclosed lumen
namespace: cellular_component
def: "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah]
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0031975
name: envelope
namespace: cellular_component
def: "A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers, and may include a cell wall layer; also includes the space between layers." [GOC:mah, GOC:pz]
subset: gosubset_prok
is_a: GO:0044464 ! cell part

[Term]
id: GO:0031976
name: plastid thylakoid
namespace: cellular_component
def: "Any thylakoid within a plastid." [GOC:pz]
is_a: GO:0009579 ! thylakoid
is_a: GO:0031984 ! organelle subcompartment
is_a: GO:0044435 ! plastid part
intersection_of: GO:0009579 ! thylakoid
intersection_of: part_of GO:0009536 ! plastid
relationship: part_of GO:0009536 ! plastid

[Term]
id: GO:0031977
name: thylakoid lumen
namespace: cellular_component
def: "The volume enclosed by a thylakoid membrane." [GOC:mah, GOC:pz]
is_a: GO:0044436 ! thylakoid part

[Term]
id: GO:0031978
name: plastid thylakoid lumen
namespace: cellular_component
def: "The volume enclosed by a plastid thylakoid membrane." [GOC:mah]
is_a: GO:0031977 ! thylakoid lumen
is_a: GO:0044435 ! plastid part
relationship: part_of GO:0031976 ! plastid thylakoid

[Term]
id: GO:0031979
name: plasma membrane-derived thylakoid lumen
namespace: cellular_component
def: "The volume enclosed by a plasma membrane-derived thylakoid." [GOC:mah, GOC:mtg_sensu]
synonym: "plasma membrane thylakoid lumen" EXACT []
is_a: GO:0031977 ! thylakoid lumen
is_a: GO:0044459 ! plasma membrane part
is_a: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen
relationship: part_of GO:0030075 ! bacterial thylakoid

[Term]
id: GO:0031981
name: nuclear lumen
namespace: cellular_component
def: "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz]
is_a: GO:0044428 ! nuclear part
is_a: GO:0070013 ! intracellular organelle lumen

[Term]
id: GO:0031982
name: vesicle
namespace: cellular_component
def: "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles]
subset: goslim_metagenomics
subset: goslim_pir
subset: gosubset_prok
xref: NIF_Subcellular:sao221389602
xref: Wikipedia:Vesicle_(biology)
is_a: GO:0043227 ! membrane-bounded organelle

[Term]
id: GO:0031983
name: vesicle lumen
namespace: cellular_component
def: "The volume enclosed by the membrane or protein that forms a vesicle." [GOC:mah, GOC:vesicles]
xref: NIF_Subcellular:sao797538226
is_a: GO:0043233 ! organelle lumen
relationship: part_of GO:0031982 ! vesicle

[Term]
id: GO:0031984
name: organelle subcompartment
namespace: cellular_component
def: "A compartment that consists of a lumen and an enclosing membrane, and is part of an organelle." [GOC:mah, GOC:pz]
comment: Note that this term refers to membrane-bounded compartments that are not considered organelles in their own right, but form parts of larger organelles.
synonym: "suborganelle compartment" EXACT []
is_a: GO:0044446 ! intracellular organelle part
relationship: part_of GO:0043227 ! membrane-bounded organelle

[Term]
id: GO:0031985
name: Golgi cisterna
namespace: cellular_component
def: "Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex." [GOC:mah]
synonym: "Golgi lamellae" RELATED [NIF_Subcellular:sao561419532]
xref: NIF_Subcellular:sao561419532
is_a: GO:0098791 ! Golgi subcompartment
relationship: part_of GO:0005795 ! Golgi stack

[Term]
id: GO:0031986
name: proteinoplast
namespace: cellular_component
def: "A leucoplast in which protein is stored." [GOC:pz]
xref: Wikipedia:Proteinoplast
is_a: GO:0009536 ! plastid

[Term]
id: GO:0031987
name: locomotion involved in locomotory behavior
namespace: biological_process
def: "Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:mah]
synonym: "locomotion during locomotory behaviour" EXACT []
is_a: GO:0040011 ! locomotion
intersection_of: GO:0040011 ! locomotion
intersection_of: part_of GO:0007626 ! locomotory behavior
relationship: part_of GO:0007626 ! locomotory behavior

[Term]
id: GO:0031988
name: membrane-bounded vesicle
namespace: cellular_component
def: "Any small, fluid-filled, spherical organelle enclosed by a lipid bilayer." [GOC:mah]
subset: gosubset_prok
synonym: "membrane-enclosed vesicle" EXACT []
is_a: GO:0031982 ! vesicle

[Term]
id: GO:0031989
name: bombesin receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a bombesin receptor binding to one of its physiological ligands." [GOC:mah]
synonym: "bombesin receptor signalling pathway" EXACT []
is_a: GO:0007186 ! G-protein coupled receptor signaling pathway

[Term]
id: GO:0031990
name: mRNA export from nucleus in response to heat stress
namespace: biological_process
def: "The directed movement of mRNA from the nucleus to the cytoplasm during a heat stimulus, a temperature stimulus above the optimal temperature for the organism; in particular, a process that enables an organism withstand exposure to temperatures that would otherwise lethally impair poly(A)+ mRNA-nucleus export." [GOC:mah, GOC:vw]
synonym: "mRNA export from cell nucleus during heat stress" EXACT []
synonym: "mRNA export from nucleus during heat stress" RELATED [GOC:dph, GOC:tb]
is_a: GO:0006406 ! mRNA export from nucleus
is_a: GO:0034605 ! cellular response to heat
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:1902582 ! single-organism intracellular transport

[Term]
id: GO:0031991
name: regulation of actomyosin contractile ring contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of contraction of the actomyosin ring involved in cytokinesis that takes place as part of a cell cycle." [GOC:dph, GOC:mah, GOC:tb]
synonym: "regulation of contractile ring contraction involved in cell cycle cytokinesis" EXACT [GOC:mah, GOC:vw]
synonym: "regulation of contractile ring contraction involved in cytokinesis during cell cycle" RELATED [GOC:dph, GOC:tb]
is_a: GO:0032506 ! cytokinetic process
is_a: GO:0032954 ! regulation of cytokinetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000916 ! actomyosin contractile ring contraction
relationship: regulates GO:0000916 ! actomyosin contractile ring contraction

[Term]
id: GO:0031992
name: energy transducer activity
namespace: molecular_function
def: "The biological transducer activity that accepts energy and converts it to another form, often by transfer to another molecule within the cell." [GOC:go_curators]
subset: goslim_pir
synonym: "light harvesting activity" RELATED []
synonym: "photon capture" RELATED []
is_a: GO:0060089 ! molecular transducer activity

[Term]
id: GO:0031993
name: light transducer activity
namespace: molecular_function
def: "Absorbing energy from one or more photons and transferring their energy to another molecule, usually a protein, within the cell." [GOC:mah, GOC:mlg]
is_a: GO:0031992 ! energy transducer activity
relationship: part_of GO:0009583 ! detection of light stimulus

[Term]
id: GO:0031994
name: insulin-like growth factor I binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with insulin-like growth factor I." [GOC:mah]
subset: goslim_chembl
synonym: "IGF-I binding" EXACT []
is_a: GO:0005520 ! insulin-like growth factor binding

[Term]
id: GO:0031995
name: insulin-like growth factor II binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with insulin-like growth factor II." [GOC:mah]
subset: goslim_chembl
synonym: "IGF-II binding" EXACT []
is_a: GO:0005520 ! insulin-like growth factor binding

[Term]
id: GO:0031996
name: thioesterase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any thioesterase enzyme." [GOC:dl]
synonym: "thiolesterase binding" EXACT []
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0031997
name: N-terminal myristoylation domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the N-terminus of a protein that has the potential to be, or has been, modified by N-terminal myristoylation. Binding affinity is typically altered by myristoylation; for example, N-terminal myristoylation of HIV Nef increases its affinity for calmodulin." [GOC:dl, GOC:jsg, PMID:15632291]
is_a: GO:0047485 ! protein N-terminus binding

[Term]
id: GO:0031998
name: regulation of fatty acid beta-oxidation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fatty acid bbeta-oxidation." [GOC:mah]
is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:0046320 ! regulation of fatty acid oxidation
is_a: GO:0050994 ! regulation of lipid catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006635 ! fatty acid beta-oxidation
relationship: regulates GO:0006635 ! fatty acid beta-oxidation

[Term]
id: GO:0031999
name: negative regulation of fatty acid beta-oxidation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid beta-oxidation." [GOC:mah]
synonym: "down regulation of fatty acid beta-oxidation" EXACT []
synonym: "down-regulation of fatty acid beta-oxidation" EXACT []
synonym: "downregulation of fatty acid beta-oxidation" EXACT []
synonym: "inhibition of fatty acid beta-oxidation" NARROW []
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:0031998 ! regulation of fatty acid beta-oxidation
is_a: GO:0046322 ! negative regulation of fatty acid oxidation
is_a: GO:0050995 ! negative regulation of lipid catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006635 ! fatty acid beta-oxidation
relationship: negatively_regulates GO:0006635 ! fatty acid beta-oxidation

[Term]
id: GO:0032000
name: positive regulation of fatty acid beta-oxidation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of fatty acid beta-oxidation." [GOC:mah]
synonym: "activation of fatty acid beta-oxidation" NARROW []
synonym: "stimulation of fatty acid beta-oxidation" NARROW []
synonym: "up regulation of fatty acid beta-oxidation" EXACT []
synonym: "up-regulation of fatty acid beta-oxidation" EXACT []
synonym: "upregulation of fatty acid beta-oxidation" EXACT []
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:0031998 ! regulation of fatty acid beta-oxidation
is_a: GO:0046321 ! positive regulation of fatty acid oxidation
is_a: GO:0050996 ! positive regulation of lipid catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006635 ! fatty acid beta-oxidation
relationship: positively_regulates GO:0006635 ! fatty acid beta-oxidation

[Term]
id: GO:0032001
name: 1,4-alpha-glucan 6-alpha-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer an alpha-D-glucosyl residue in a (1->4)-alpha-D-glucan to the primary hydroxy group of glucose, free or combined in a (1->4)-alpha-D-glucan." [EC:2.4.1.24]
synonym: "1,4-alpha-D-glucan 6-alpha-D-glucosyltransferase activity" EXACT []
synonym: "1,4-alpha-D-glucan:1,4-alpha-D-glucan(D-glucose) 6-alpha-D-glucosyltransferase activity" EXACT []
synonym: "D-glucosyltransferase" BROAD []
synonym: "oligoglucan-branching glycosyltransferase activity" RELATED [EC:2.4.1.24]
synonym: "T-enzyme" NARROW []
xref: EC:2.4.1.24
xref: MetaCyc:2.4.1.24-RXN
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0032002
name: interleukin-28 receptor complex
namespace: cellular_component
def: "A protein complex that binds interleukin-28 and interleukin-29. Composed of two subunits, IL-28R alpha and IL-10R beta." [GOC:rph]
synonym: "IL-28 receptor complex" EXACT [GOC:add]
is_a: GO:0098802 ! plasma membrane receptor complex
relationship: part_of GO:0005887 ! integral component of plasma membrane

[Term]
id: GO:0032003
name: interleukin-28 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-28 receptor." [GOC:rph]
synonym: "IL-28" NARROW []
synonym: "interleukin-28 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0032005
name: signal transduction involved in conjugation with cellular fusion
namespace: biological_process
def: "The series of molecular signals that bring about the relay, amplification or dampening of a signal generated in response to a cue, such as starvation or pheromone exposure, in organisms that undergo conjugation with cellular fusion." [GOC:mah]
is_a: GO:0007165 ! signal transduction
is_a: GO:0022414 ! reproductive process
intersection_of: GO:0007165 ! signal transduction
intersection_of: part_of GO:0000747 ! conjugation with cellular fusion
relationship: part_of GO:0000747 ! conjugation with cellular fusion

[Term]
id: GO:0032006
name: regulation of TOR signaling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of TOR signaling." [GOC:mah]
synonym: "regulation of target of rapamycin signaling pathway" EXACT []
synonym: "regulation of target of rapamycin signalling pathway" EXACT []
synonym: "regulation of TOR signaling cascade" RELATED [GOC:signaling]
synonym: "regulation of TOR signaling pathway" EXACT []
synonym: "regulation of TOR signalling pathway" EXACT []
is_a: GO:1902531 ! regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031929 ! TOR signaling
relationship: regulates GO:0031929 ! TOR signaling

[Term]
id: GO:0032007
name: negative regulation of TOR signaling
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling." [GOC:mah]
synonym: "down regulation of TOR signaling pathway" EXACT []
synonym: "down-regulation of TOR signaling pathway" EXACT []
synonym: "downregulation of TOR signaling pathway" EXACT []
synonym: "inhibition of TOR signaling pathway" NARROW []
synonym: "negative regulation of target of rapamycin signaling pathway" EXACT []
synonym: "negative regulation of target of rapamycin signalling pathway" EXACT []
synonym: "negative regulation of TOR signaling cascade" RELATED [GOC:signaling]
synonym: "negative regulation of TOR signaling pathway" EXACT []
synonym: "negative regulation of TOR signalling pathway" EXACT []
is_a: GO:0032006 ! regulation of TOR signaling
is_a: GO:1902532 ! negative regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0031929 ! TOR signaling
relationship: negatively_regulates GO:0031929 ! TOR signaling

[Term]
id: GO:0032008
name: positive regulation of TOR signaling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of TOR signaling." [GOC:mah]
synonym: "activation of TOR signaling pathway" NARROW []
synonym: "positive regulation of target of rapamycin signaling pathway" EXACT []
synonym: "positive regulation of target of rapamycin signalling pathway" EXACT []
synonym: "positive regulation of TOR signaling cascade" RELATED [GOC:signaling]
synonym: "positive regulation of TOR signaling pathway" EXACT []
synonym: "positive regulation of TOR signalling pathway" EXACT []
synonym: "stimulation of TOR signaling pathway" NARROW []
synonym: "up regulation of TOR signaling pathway" EXACT []
synonym: "up-regulation of TOR signaling pathway" EXACT []
synonym: "upregulation of TOR signaling pathway" EXACT []
is_a: GO:0032006 ! regulation of TOR signaling
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0031929 ! TOR signaling
relationship: positively_regulates GO:0031929 ! TOR signaling

[Term]
id: GO:0032009
name: early phagosome
namespace: cellular_component
def: "A membrane-bounded intracellular vesicle as initially formed upon the ingestion of particulate material by phagocytosis." [GOC:mah, PMID:12388753]
synonym: "early phagocytic vesicle" EXACT []
is_a: GO:0045335 ! phagocytic vesicle

[Term]
id: GO:0032010
name: phagolysosome
namespace: cellular_component
def: "A membrane-bounded intracellular vesicle formed by maturation of an early phagosome following the ingestion of particulate material by phagocytosis; during maturation, phagosomes acquire markers of late endosomes and lysosomes." [GOC:mah, PMID:12388753]
synonym: "late phagocytic vesicle" RELATED []
synonym: "late phagosome" RELATED []
xref: Wikipedia:Phagolysosome
is_a: GO:0005767 ! secondary lysosome
is_a: GO:0045335 ! phagocytic vesicle

[Term]
id: GO:0032011
name: ARF protein signal transduction
namespace: biological_process
def: "A series of molecular signals within the cell that are mediated by a member of the ARF family of proteins switching to a GTP-bound active state." [GOC:mah]
is_a: GO:0007265 ! Ras protein signal transduction

[Term]
id: GO:0032012
name: regulation of ARF protein signal transduction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ARF protein signal transduction." [GOC:mah]
is_a: GO:0046578 ! regulation of Ras protein signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032011 ! ARF protein signal transduction
relationship: regulates GO:0032011 ! ARF protein signal transduction

[Term]
id: GO:0032013
name: negative regulation of ARF protein signal transduction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ARF protein signal transduction." [GOC:mah]
synonym: "down regulation of ARF protein signal transduction" EXACT []
synonym: "down-regulation of ARF protein signal transduction" EXACT []
synonym: "downregulation of ARF protein signal transduction" EXACT []
synonym: "inhibition of ARF protein signal transduction" NARROW []
is_a: GO:0032012 ! regulation of ARF protein signal transduction
is_a: GO:0046580 ! negative regulation of Ras protein signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032011 ! ARF protein signal transduction
relationship: negatively_regulates GO:0032011 ! ARF protein signal transduction

[Term]
id: GO:0032014
name: positive regulation of ARF protein signal transduction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ARF protein signal transduction." [GOC:mah]
synonym: "activation of ARF protein signal transduction" NARROW []
synonym: "stimulation of ARF protein signal transduction" NARROW []
synonym: "up regulation of ARF protein signal transduction" EXACT []
synonym: "up-regulation of ARF protein signal transduction" EXACT []
synonym: "upregulation of ARF protein signal transduction" EXACT []
is_a: GO:0032012 ! regulation of ARF protein signal transduction
is_a: GO:0046579 ! positive regulation of Ras protein signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032011 ! ARF protein signal transduction
relationship: positively_regulates GO:0032011 ! ARF protein signal transduction

[Term]
id: GO:0032015
name: regulation of Ran protein signal transduction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Ran protein signal transduction." [GOC:mah]
is_a: GO:0046578 ! regulation of Ras protein signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031291 ! Ran protein signal transduction
relationship: regulates GO:0031291 ! Ran protein signal transduction

[Term]
id: GO:0032016
name: negative regulation of Ran protein signal transduction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Ran protein signal transduction." [GOC:mah]
synonym: "down regulation of Ran protein signal transduction" EXACT []
synonym: "down-regulation of Ran protein signal transduction" EXACT []
synonym: "downregulation of Ran protein signal transduction" EXACT []
synonym: "inhibition of Ran protein signal transduction" NARROW []
is_a: GO:0032015 ! regulation of Ran protein signal transduction
is_a: GO:0046580 ! negative regulation of Ras protein signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0031291 ! Ran protein signal transduction
relationship: negatively_regulates GO:0031291 ! Ran protein signal transduction

[Term]
id: GO:0032017
name: positive regulation of Ran protein signal transduction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of Ran protein signal transduction." [GOC:mah]
synonym: "activation of Ran protein signal transduction" NARROW []
synonym: "stimulation of Ran protein signal transduction" NARROW []
synonym: "up regulation of Ran protein signal transduction" EXACT []
synonym: "up-regulation of Ran protein signal transduction" EXACT []
synonym: "upregulation of Ran protein signal transduction" EXACT []
is_a: GO:0032015 ! regulation of Ran protein signal transduction
is_a: GO:0046579 ! positive regulation of Ras protein signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0031291 ! Ran protein signal transduction
relationship: positively_regulates GO:0031291 ! Ran protein signal transduction

[Term]
id: GO:0032018
name: 2-methylbutanol:NADP oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-methylbutanol + NADP+ = 2-methylbutanal + NADPH + H+." [GOC:mah, PMID:12210903]
synonym: "2-methylbutanal reductase (NADP) activity" EXACT []
synonym: "2-methylbutyraldehyde reductase (NADP) activity" EXACT []
is_a: GO:0008106 ! alcohol dehydrogenase (NADP+) activity

[Term]
id: GO:0032019
name: mitochondrial cloud
namespace: cellular_component
def: "A prominent mass in the cytoplasm of previtellogenic oocytes. The cloud contains both mitochondria and electron-dense granulofibrillar material (GFM) and is the source of germinal granule material." [PMID:6541166]
synonym: "Balbiani body" EXACT []
synonym: "mitochondrial aggregate" RELATED []
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0032020
name: ISG15-protein conjugation
namespace: biological_process
def: "The covalent addition to a protein of ISG15, a ubiquitin-like protein." [GOC:mah]
is_a: GO:0006464 ! cellular protein modification process

[Term]
id: GO:0032021
name: NELF complex
namespace: cellular_component
def: "A complex of five proteins, designated NELF-A, -B, -C, -D, and -E in human, that can physically associate with RNP polymerase II to induce transcriptional pausing." [PMID:12612062]
synonym: "negative elongation factor complex" EXACT []
is_a: GO:0008023 ! transcription elongation factor complex

[Term]
id: GO:0032022
name: multicellular pellicle formation
namespace: biological_process
def: "A process in which microorganisms produce an extracellular matrix and form multicellular aggregates at an air-liquid interface." [GOC:ml]
is_a: GO:0090606 ! single-species surface biofilm formation

[Term]
id: GO:0032023
name: trypsinogen activation
namespace: biological_process
def: "The proteolytic processing of trypsinogen to the active form, trypsin." [GOC:mah]
synonym: "cleavage of trypsinogen to trypsin" EXACT []
is_a: GO:0031638 ! zymogen activation

[Term]
id: GO:0032024
name: positive regulation of insulin secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of insulin." [GOC:mah]
synonym: "activation of insulin secretion" NARROW []
synonym: "stimulation of insulin secretion" NARROW []
synonym: "up regulation of insulin secretion" EXACT []
synonym: "up-regulation of insulin secretion" EXACT []
synonym: "upregulation of insulin secretion" EXACT []
is_a: GO:0050714 ! positive regulation of protein secretion
is_a: GO:0050796 ! regulation of insulin secretion
is_a: GO:0090277 ! positive regulation of peptide hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030073 ! insulin secretion
relationship: positively_regulates GO:0030073 ! insulin secretion

[Term]
id: GO:0032025
name: response to cobalt ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalt ion stimulus." [GOC:mah]
is_a: GO:0010038 ! response to metal ion

[Term]
id: GO:0032026
name: response to magnesium ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus." [GOC:mah]
is_a: GO:0010038 ! response to metal ion

[Term]
id: GO:0032027
name: myosin light chain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a light chain of a myosin complex." [GOC:mah]
is_a: GO:0017022 ! myosin binding

[Term]
id: GO:0032028
name: myosin head/neck binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the head/neck region of a myosin heavy chain." [GOC:mah]
is_a: GO:0032036 ! myosin heavy chain binding

[Term]
id: GO:0032029
name: myosin tail binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the tail region of a myosin heavy chain." [GOC:mah]
is_a: GO:0032036 ! myosin heavy chain binding

[Term]
id: GO:0032030
name: myosin I light chain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a light chain of a myosin I complex." [GOC:mah]
is_a: GO:0017024 ! myosin I binding
is_a: GO:0032027 ! myosin light chain binding

[Term]
id: GO:0032031
name: myosin I head/neck binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the head/neck region of a myosin I heavy chain." [GOC:mah]
is_a: GO:0032028 ! myosin head/neck binding
is_a: GO:0032037 ! myosin I heavy chain binding

[Term]
id: GO:0032032
name: myosin I tail binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the tail region of a myosin I heavy chain." [GOC:mah]
is_a: GO:0032029 ! myosin tail binding
is_a: GO:0032037 ! myosin I heavy chain binding

[Term]
id: GO:0032033
name: myosin II light chain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a light chain of a myosin II complex." [GOC:mah]
is_a: GO:0032027 ! myosin light chain binding
is_a: GO:0045159 ! myosin II binding

[Term]
id: GO:0032034
name: myosin II head/neck binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the head/neck region of a myosin II heavy chain." [GOC:mah]
is_a: GO:0032028 ! myosin head/neck binding
is_a: GO:0032038 ! myosin II heavy chain binding

[Term]
id: GO:0032035
name: myosin II tail binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the tail region of a myosin II heavy chain." [GOC:mah]
is_a: GO:0032029 ! myosin tail binding
is_a: GO:0032038 ! myosin II heavy chain binding

[Term]
id: GO:0032036
name: myosin heavy chain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a heavy chain of a myosin complex." [GOC:mah]
is_a: GO:0017022 ! myosin binding

[Term]
id: GO:0032037
name: myosin I heavy chain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a heavy chain of a myosin I complex." [GOC:mah]
is_a: GO:0017024 ! myosin I binding
is_a: GO:0032036 ! myosin heavy chain binding

[Term]
id: GO:0032038
name: myosin II heavy chain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a heavy chain of a myosin II complex." [GOC:mah]
is_a: GO:0032036 ! myosin heavy chain binding
is_a: GO:0045159 ! myosin II binding

[Term]
id: GO:0032039
name: integrator complex
namespace: cellular_component
def: "A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II." [PMID:16239144]
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part
relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme

[Term]
id: GO:0032040
name: small-subunit processome
namespace: cellular_component
def: "A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [GOC:krc, GOC:vw, PMID:12068309, PMID:12957375, PMID:15120992, PMID:15590835]
synonym: "small subunit processome" EXACT []
synonym: "SSU processome" EXACT []
is_a: GO:0030684 ! preribosome
relationship: has_part GO:0034455 ! t-UTP complex

[Term]
id: GO:0032041
name: NAD-dependent histone deacetylase activity (H3-K14 specific)
namespace: molecular_function
def: "Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein." [EC:3.5.1.17, RHEA:24551]
xref: EC:3.5.1.98
is_a: GO:0017136 ! NAD-dependent histone deacetylase activity
is_a: GO:0031078 ! histone deacetylase activity (H3-K14 specific)

[Term]
id: GO:0032042
name: mitochondrial DNA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mitochondrial DNA." [GOC:mah]
synonym: "mitochondrial DNA metabolism" EXACT []
synonym: "mtDNA metabolic process" EXACT []
synonym: "mtDNA metabolism" EXACT []
is_a: GO:0006259 ! DNA metabolic process
intersection_of: GO:0006259 ! DNA metabolic process
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion
relationship: part_of GO:0000002 ! mitochondrial genome maintenance

[Term]
id: GO:0032043
name: mitochondrial DNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of mitochondrial DNA." [GOC:mah]
synonym: "mitochondrial DNA breakdown" EXACT []
synonym: "mitochondrial DNA catabolism" EXACT []
synonym: "mitochondrial DNA degradation" EXACT []
synonym: "mtDNA breakdown" EXACT []
synonym: "mtDNA catabolic process" EXACT []
synonym: "mtDNA catabolism" EXACT []
synonym: "mtDNA degradation" EXACT []
is_a: GO:0006308 ! DNA catabolic process
is_a: GO:0032042 ! mitochondrial DNA metabolic process
intersection_of: GO:0006308 ! DNA catabolic process
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion

[Term]
id: GO:0032044
name: DSIF complex
namespace: cellular_component
def: "A heterodimeric protein complex formed of Spt4 and Spt5 proteins which is expressed in eukaryotes from yeast to man. DSIF is an inhibitory elongation factor that promotes RNA polymerase II transcriptional pausing, but can also stimulate transcriptional elongation under certain conditions, and may play a role in RNA processing via its physical association with mRNA capping enzymes." [PMID:12242279, PMID:12653964, PMID:12676794, PMID:16581788, PMID:19460865]
synonym: "5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole sensitivity inducing factor complex" EXACT []
synonym: "DRB sensitivity inducing factor complex" EXACT []
synonym: "Spt4-Spt5 complex" EXACT []
synonym: "Spt5-Spt4 complex" EXACT [GOC:vw]
is_a: GO:0008023 ! transcription elongation factor complex

[Term]
id: GO:0032045
name: guanyl-nucleotide exchange factor complex
namespace: cellular_component
def: "A protein complex that stimulates the exchange of guanyl nucleotides associated with a GTPase." [GOC:mah]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0032046
name: micropexophagy-specific membrane apparatus
namespace: cellular_component
def: "A membrane-bounded flattened sac that is formed during micropexophagy between the membrane tips of an engulfing vacuole, completing the engulfment and sequestration of peroxisomes from the cytosol, and forming a micropexophagic body within the lumen of the vacuole." [PMID:15563611]
synonym: "micropexophagic apparatus" EXACT []
synonym: "MIPA" EXACT []
is_a: GO:0031984 ! organelle subcompartment
is_a: GO:0044437 ! vacuolar part

[Term]
id: GO:0032047
name: mitosome
namespace: cellular_component
def: "A double-membrane-bounded organelle that functions in iron-sulfur protein maturation; evolutionarily derived from mitochondria. The mitosome has been detected only in anaerobic or microaerophilic organisms that do not have mitochondria, such as Entamoeba histolytica, Giardia intestinalis and several species of Microsporidia. These organisms are not capable of gaining energy from oxidative phosphorylation, which is normally performed by mitochondria." [GOC:giardia, PMID:10361303, PMID:14614504, PMID:24316280]
comment: In Giardia species, mitosomes are sometimes present between the two nuclei.
synonym: "crypton" EXACT []
xref: Wikipedia:Mitosome
is_a: GO:0043231 ! intracellular membrane-bounded organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0032048
name: cardiolipin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cardiolipin, 1,3-bis(3-phosphatidyl)glycerol." [CHEBI:28494, GOC:mah]
synonym: "cardiolipin metabolism" EXACT []
synonym: "diphosphatidylglycerol metabolic process" RELATED []
synonym: "diphosphatidylglycerol metabolism" RELATED []
is_a: GO:0046471 ! phosphatidylglycerol metabolic process

[Term]
id: GO:0032049
name: cardiolipin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol." [CHEBI:28494, GOC:mah]
synonym: "diphosphatidylglycerol biosynthesis" RELATED []
synonym: "diphosphatidylglycerol biosynthetic process" RELATED []
xref: MetaCyc:PWY-5269
is_a: GO:0006655 ! phosphatidylglycerol biosynthetic process
is_a: GO:0032048 ! cardiolipin metabolic process

[Term]
id: GO:0032050
name: clathrin heavy chain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a clathrin heavy chain." [GOC:mah]
is_a: GO:0030276 ! clathrin binding

[Term]
id: GO:0032051
name: clathrin light chain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a clathrin light chain." [GOC:mah]
is_a: GO:0030276 ! clathrin binding

[Term]
id: GO:0032052
name: bile acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with bile acids, any of a group of steroid carboxylic acids occurring in bile." [GOC:rph]
is_a: GO:0005496 ! steroid binding
is_a: GO:0033293 ! monocarboxylic acid binding

[Term]
id: GO:0032053
name: ciliary basal body organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ciliary basal body, a short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum)." [GOC:cilia, GOC:dph, GOC:jl, GOC:mah, PMID:9889124]
synonym: "microtubule basal body organisation" BROAD [GOC:mah]
synonym: "microtubule basal body organization" BROAD []
synonym: "microtubule basal body organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0031023 ! microtubule organizing center organization

[Term]
id: GO:0032054
name: ciliary basal body duplication
namespace: biological_process
def: "Construction of a new ciliary basal body." [GOC:cilia, PMID:9889124]
synonym: "microtubule basal body duplication" BROAD []
is_a: GO:0032053 ! ciliary basal body organization

[Term]
id: GO:0032055
name: negative regulation of translation in response to stress
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate of translation as a result of a stimulus indicating the organism is under stress." [GOC:mah]
synonym: "down regulation of translation in response to stress" EXACT []
synonym: "down-regulation of translation in response to stress" EXACT []
synonym: "downregulation of translation in response to stress" EXACT []
synonym: "inhibition of translation in response to stress" NARROW []
is_a: GO:0017148 ! negative regulation of translation
is_a: GO:0043555 ! regulation of translation in response to stress

[Term]
id: GO:0032056
name: positive regulation of translation in response to stress
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress." [GOC:mah]
synonym: "activation of translation in response to stress" NARROW []
synonym: "stimulation of translation in response to stress" NARROW []
synonym: "up regulation of translation in response to stress" EXACT []
synonym: "up-regulation of translation in response to stress" EXACT []
synonym: "upregulation of translation in response to stress" EXACT []
is_a: GO:0043555 ! regulation of translation in response to stress
is_a: GO:0045727 ! positive regulation of translation

[Term]
id: GO:0032057
name: negative regulation of translational initiation in response to stress
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate of translation initiation as a result of a stimulus indicating the organism is under stress." [GOC:mah]
synonym: "down regulation of translation initiation in response to stress" EXACT []
synonym: "down-regulation of translation initiation in response to stress" EXACT []
synonym: "downregulation of translation initiation in response to stress" EXACT []
synonym: "inhibition of translation initiation in response to stress" NARROW []
is_a: GO:0032055 ! negative regulation of translation in response to stress
is_a: GO:0043558 ! regulation of translational initiation in response to stress
is_a: GO:0045947 ! negative regulation of translational initiation

[Term]
id: GO:0032058
name: positive regulation of translational initiation in response to stress
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of translation initiation as a result of a stimulus indicating the organism is under stress." [GOC:mah]
synonym: "activation of translation initiation in response to stress" NARROW []
synonym: "stimulation of translation initiation in response to stress" NARROW []
synonym: "up regulation of translation initiation in response to stress" EXACT []
synonym: "up-regulation of translation initiation in response to stress" EXACT []
synonym: "upregulation of translation initiation in response to stress" EXACT []
is_a: GO:0032056 ! positive regulation of translation in response to stress
is_a: GO:0043558 ! regulation of translational initiation in response to stress
is_a: GO:0045948 ! positive regulation of translational initiation

[Term]
id: GO:0032059
name: bleb
namespace: cellular_component
def: "A cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Blebs are formed during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses." [GOC:mtg_apoptosis, http://en.wikipedia.org/wiki/Bleb_(cell_biology), PMID:12083798, PMID:16624291]
subset: goslim_pir
synonym: "plasma membrane bleb" EXACT [GOC:pr]
xref: Wikipedia:Bleb_(cell_biology)
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0032060
name: bleb assembly
namespace: biological_process
def: "The assembly of a bleb, a cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Plasma membrane blebbing occurs during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses." [GOC:mah, GOC:mtg_apoptosis, http://en.wikipedia.org/wiki/Bleb_(cell_biology), PMID:12083798, PMID:16624291]
synonym: "blebbing" BROAD [GOC:pr]
synonym: "cell blebbing" EXACT []
synonym: "membrane blebbing" BROAD [GOC:pr]
synonym: "plasma membrane bleb assembly" EXACT [GOC:pr]
synonym: "plasma membrane blebbing" EXACT [GOC:pr]
is_a: GO:0030031 ! cell projection assembly

[Term]
id: GO:0032061
name: negative regulation of translation in response to osmotic stress
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate of translation as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:mah]
synonym: "down regulation of translation in response to osmotic stress" EXACT []
synonym: "down-regulation of translation in response to osmotic stress" EXACT []
synonym: "downregulation of translation in response to osmotic stress" EXACT []
synonym: "inhibition of translation in response to osmotic stress" NARROW []
is_a: GO:0032055 ! negative regulation of translation in response to stress
is_a: GO:0043557 ! regulation of translation in response to osmotic stress

[Term]
id: GO:0032062
name: positive regulation of translation in response to osmotic stress
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:mah]
synonym: "activation of translation in response to osmotic stress" NARROW []
synonym: "stimulation of translation in response to osmotic stress" NARROW []
synonym: "up regulation of translation in response to osmotic stress" EXACT []
synonym: "up-regulation of translation in response to osmotic stress" EXACT []
synonym: "upregulation of translation in response to osmotic stress" EXACT []
is_a: GO:0032056 ! positive regulation of translation in response to stress
is_a: GO:0043557 ! regulation of translation in response to osmotic stress

[Term]
id: GO:0032063
name: negative regulation of translational initiation in response to osmotic stress
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate of translation initiation, as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:mah]
synonym: "down regulation of translation initiation in response to osmotic stress" EXACT []
synonym: "down-regulation of translation initiation in response to osmotic stress" EXACT []
synonym: "downregulation of translation initiation in response to osmotic stress" EXACT []
synonym: "inhibition of translation initiation in response to osmotic stress" NARROW []
is_a: GO:0032057 ! negative regulation of translational initiation in response to stress
is_a: GO:0032061 ! negative regulation of translation in response to osmotic stress
is_a: GO:0043561 ! regulation of translational initiation in response to osmotic stress

[Term]
id: GO:0032064
name: positive regulation of translational initiation in response to osmotic stress
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of translation initiation, as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:mah]
synonym: "activation of translation initiation in response to osmotic stress" NARROW []
synonym: "stimulation of translation initiation in response to osmotic stress" NARROW []
synonym: "up regulation of translation initiation in response to osmotic stress" EXACT []
synonym: "up-regulation of translation initiation in response to osmotic stress" EXACT []
synonym: "upregulation of translation initiation in response to osmotic stress" EXACT []
is_a: GO:0032058 ! positive regulation of translational initiation in response to stress
is_a: GO:0032062 ! positive regulation of translation in response to osmotic stress
is_a: GO:0043561 ! regulation of translational initiation in response to osmotic stress

[Term]
id: GO:0032065
name: cortical protein anchoring
namespace: biological_process
def: "A process in which a protein or protein complex is maintained in a specific location in the cell cortex." [GOC:vw]
synonym: "maintenance of protein location in cell cortex" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051220 ! cytoplasmic sequestering of protein
intersection_of: GO:0045185 ! maintenance of protein location
intersection_of: occurs_in GO:0005938 ! cell cortex
relationship: occurs_in GO:0005938 ! cell cortex

[Term]
id: GO:0032066
name: nucleolus to nucleoplasm transport
namespace: biological_process
def: "The directed movement of substances from the nucleolus to the nucleoplasm." [GOC:mah]
is_a: GO:0051169 ! nuclear transport
is_a: GO:1902582 ! single-organism intracellular transport

[Term]
id: GO:0032067
name: Type IV site-specific deoxyribonuclease activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of DNA in a site specific manner. Cleavage is dependent on the presence of a specific recognition site in the DNA which must be modified (e.g. methylated, hydroxymethylated, glucosyl-hydroxymethylated)." [PMID:12654995]
synonym: "Type IV restriction enzyme activity" EXACT []
is_a: GO:0015666 ! restriction endodeoxyribonuclease activity

[Term]
id: GO:0032068
name: Type IV site-specific deoxyribonuclease complex
namespace: cellular_component
def: "A complex consisting of two proteins which acts as an endonuclease in DNA sequences containing a specific modified recognition site. Modifications may include methylation, hydroxymethylation, and glucosyl-hydroxymethylation." [PMID:12654995]
synonym: "Type IV restriction enzyme complex" EXACT []
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0032069
name: regulation of nuclease activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids." [GOC:mah]
synonym: "nuclease regulator activity" RELATED []
is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process
is_a: GO:0051336 ! regulation of hydrolase activity
is_a: GO:0060255 ! regulation of macromolecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004518 ! nuclease activity
relationship: regulates GO:0004518 ! nuclease activity

[Term]
id: GO:0032070
name: regulation of deoxyribonuclease activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid." [GOC:mah]
synonym: "deoxyribonuclease regulator" RELATED []
synonym: "DNase regulator" RELATED []
is_a: GO:0032069 ! regulation of nuclease activity
is_a: GO:0051052 ! regulation of DNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004536 ! deoxyribonuclease activity
relationship: regulates GO:0004536 ! deoxyribonuclease activity

[Term]
id: GO:0032071
name: regulation of endodeoxyribonuclease activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks." [GOC:mah]
synonym: "endodeoxyribonuclease regulator" RELATED []
is_a: GO:0032070 ! regulation of deoxyribonuclease activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004520 ! endodeoxyribonuclease activity
relationship: regulates GO:0004520 ! endodeoxyribonuclease activity

[Term]
id: GO:0032072
name: regulation of restriction endodeoxyribonuclease activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a restriction endodeoxyribonuclease activity, the catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks." [GOC:mah]
is_a: GO:0032071 ! regulation of endodeoxyribonuclease activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0015666 ! restriction endodeoxyribonuclease activity
relationship: regulates GO:0015666 ! restriction endodeoxyribonuclease activity

[Term]
id: GO:0032073
name: negative regulation of restriction endodeoxyribonuclease activity
namespace: biological_process
def: "Any process that stops or reduces the rate of a restriction endodeoxyribonuclease activity, the catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks." [GOC:mah]
synonym: "down regulation of restriction endodeoxyribonuclease activity" EXACT []
synonym: "down-regulation of restriction endodeoxyribonuclease activity" EXACT []
synonym: "downregulation of restriction endodeoxyribonuclease activity" EXACT []
synonym: "inhibition of restriction endodeoxyribonuclease activity" NARROW []
synonym: "restriction alleviation" NARROW []
synonym: "restriction endodeoxyribonuclease inhibitor" RELATED []
synonym: "restriction enzyme inhibitor" RELATED []
is_a: GO:0032072 ! regulation of restriction endodeoxyribonuclease activity
is_a: GO:0032078 ! negative regulation of endodeoxyribonuclease activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0015666 ! restriction endodeoxyribonuclease activity
relationship: negatively_regulates GO:0015666 ! restriction endodeoxyribonuclease activity

[Term]
id: GO:0032074
name: negative regulation of nuclease activity
namespace: biological_process
def: "Any process that stops or reduces the rate of nuclease activity, the hydrolysis of ester linkages within nucleic acids." [GOC:mah]
synonym: "down regulation of nuclease activity" EXACT []
synonym: "down-regulation of nuclease activity" EXACT []
synonym: "downregulation of nuclease activity" EXACT []
synonym: "inhibition of nuclease activity" NARROW []
synonym: "nuclease inhibitor" RELATED []
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0032069 ! regulation of nuclease activity
is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process
is_a: GO:0051346 ! negative regulation of hydrolase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004518 ! nuclease activity
relationship: negatively_regulates GO:0004518 ! nuclease activity

[Term]
id: GO:0032075
name: positive regulation of nuclease activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids." [GOC:mah]
synonym: "activation of nuclease activity" NARROW []
synonym: "nuclease activator" RELATED []
synonym: "stimulation of nuclease activity" NARROW []
synonym: "up regulation of nuclease activity" EXACT []
synonym: "up-regulation of nuclease activity" EXACT []
synonym: "upregulation of nuclease activity" EXACT []
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0032069 ! regulation of nuclease activity
is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process
is_a: GO:0051345 ! positive regulation of hydrolase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004518 ! nuclease activity
relationship: positively_regulates GO:0004518 ! nuclease activity

[Term]
id: GO:0032076
name: negative regulation of deoxyribonuclease activity
namespace: biological_process
def: "Any process that stops or reduces the rate of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid." [GOC:mah]
synonym: "deoxyribonuclease inhibitor" RELATED []
synonym: "DNase inhibitor" RELATED []
synonym: "down regulation of deoxyribonuclease activity" EXACT []
synonym: "down-regulation of deoxyribonuclease activity" EXACT []
synonym: "downregulation of deoxyribonuclease activity" EXACT []
synonym: "inhibition of deoxyribonuclease activity" NARROW []
is_a: GO:0032070 ! regulation of deoxyribonuclease activity
is_a: GO:0032074 ! negative regulation of nuclease activity
is_a: GO:0051053 ! negative regulation of DNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004536 ! deoxyribonuclease activity
relationship: negatively_regulates GO:0004536 ! deoxyribonuclease activity

[Term]
id: GO:0032077
name: positive regulation of deoxyribonuclease activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid." [GOC:mah]
synonym: "activation of deoxyribonuclease activity" NARROW []
synonym: "deoxyribonuclease activator" RELATED []
synonym: "DNase activator" RELATED []
synonym: "stimulation of deoxyribonuclease activity" NARROW []
synonym: "up regulation of deoxyribonuclease activity" EXACT []
synonym: "up-regulation of deoxyribonuclease activity" EXACT []
synonym: "upregulation of deoxyribonuclease activity" EXACT []
is_a: GO:0032070 ! regulation of deoxyribonuclease activity
is_a: GO:0032075 ! positive regulation of nuclease activity
is_a: GO:0051054 ! positive regulation of DNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004536 ! deoxyribonuclease activity
relationship: positively_regulates GO:0004536 ! deoxyribonuclease activity

[Term]
id: GO:0032078
name: negative regulation of endodeoxyribonuclease activity
namespace: biological_process
def: "Any process that stops or reduces the rate of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks." [GOC:mah]
synonym: "down regulation of endodeoxyribonuclease activity" EXACT []
synonym: "down-regulation of endodeoxyribonuclease activity" EXACT []
synonym: "downregulation of endodeoxyribonuclease activity" EXACT []
synonym: "endodeoxyribonuclease inhibitor" RELATED []
synonym: "inhibition of endodeoxyribonuclease activity" NARROW []
is_a: GO:0032071 ! regulation of endodeoxyribonuclease activity
is_a: GO:0032076 ! negative regulation of deoxyribonuclease activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004520 ! endodeoxyribonuclease activity
relationship: negatively_regulates GO:0004520 ! endodeoxyribonuclease activity

[Term]
id: GO:0032079
name: positive regulation of endodeoxyribonuclease activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks." [GOC:mah]
synonym: "activation of endodeoxyribonuclease activity" NARROW []
synonym: "endodeoxyribonuclease activator" RELATED []
synonym: "stimulation of endodeoxyribonuclease activity" NARROW []
synonym: "up regulation of endodeoxyribonuclease activity" EXACT []
synonym: "up-regulation of endodeoxyribonuclease activity" EXACT []
synonym: "upregulation of endodeoxyribonuclease activity" EXACT []
is_a: GO:0032071 ! regulation of endodeoxyribonuclease activity
is_a: GO:0032077 ! positive regulation of deoxyribonuclease activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004520 ! endodeoxyribonuclease activity
relationship: positively_regulates GO:0004520 ! endodeoxyribonuclease activity

[Term]
id: GO:0032080
name: negative regulation of Type I site-specific deoxyribonuclease activity
namespace: biological_process
def: "Any process that stops or reduces the rate of Type I restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah, GOC:tb]
synonym: "down regulation of Type I restriction endodeoxyribonuclease activity" EXACT []
synonym: "down-regulation of Type I restriction endodeoxyribonuclease activity" EXACT []
synonym: "downregulation of Type I restriction endodeoxyribonuclease activity" EXACT []
synonym: "inhibition of Type I restriction endodeoxyribonuclease activity" NARROW []
synonym: "negative regulation of Type I restriction endodeoxyribonuclease activity" EXACT [GOC:dph, GOC:tb]
synonym: "Type I restriction endodeoxyribonuclease inhibitor" RELATED []
synonym: "Type I restriction enzyme inhibitor" RELATED []
is_a: GO:0032073 ! negative regulation of restriction endodeoxyribonuclease activity
is_a: GO:0032084 ! regulation of Type I site-specific deoxyribonuclease activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009035 ! Type I site-specific deoxyribonuclease activity
relationship: negatively_regulates GO:0009035 ! Type I site-specific deoxyribonuclease activity

[Term]
id: GO:0032081
name: negative regulation of Type II site-specific deoxyribonuclease activity
namespace: biological_process
def: "Any process that stops or reduces the rate of Type II restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah, GOC:tb]
synonym: "down regulation of Type II restriction endodeoxyribonuclease activity" EXACT []
synonym: "down-regulation of Type II restriction endodeoxyribonuclease activity" EXACT []
synonym: "downregulation of Type II restriction endodeoxyribonuclease activity" EXACT []
synonym: "inhibition of Type II restriction endodeoxyribonuclease activity" NARROW []
synonym: "negative regulation of Type II restriction endodeoxyribonuclease activity" EXACT [GOC:dph, GOC:tb]
synonym: "Type II restriction endodeoxyribonuclease inhibitor" RELATED []
synonym: "Type II restriction enzyme inhibitor" RELATED []
is_a: GO:0032073 ! negative regulation of restriction endodeoxyribonuclease activity
is_a: GO:0032085 ! regulation of Type II site-specific deoxyribonuclease activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009036 ! Type II site-specific deoxyribonuclease activity
relationship: negatively_regulates GO:0009036 ! Type II site-specific deoxyribonuclease activity

[Term]
id: GO:0032082
name: negative regulation of Type III site-specific deoxyribonuclease activity
namespace: biological_process
def: "Any process that stops or reduces the rate of Type III restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah, GOC:tb]
synonym: "down regulation of Type III restriction endodeoxyribonuclease activity" EXACT []
synonym: "down-regulation of Type III restriction endodeoxyribonuclease activity" EXACT []
synonym: "downregulation of Type III restriction endodeoxyribonuclease activity" EXACT []
synonym: "inhibition of Type III restriction endodeoxyribonuclease activity" NARROW []
synonym: "negative regulation of Type III restriction endodeoxyribonuclease activity" EXACT [GOC:dph, GOC:tb]
synonym: "Type III restriction endodeoxyribonuclease inhibitor" RELATED []
synonym: "Type III restriction enzyme inhibitor" RELATED []
is_a: GO:0032073 ! negative regulation of restriction endodeoxyribonuclease activity
is_a: GO:0032086 ! regulation of Type III site-specific deoxyribonuclease activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0015668 ! Type III site-specific deoxyribonuclease activity
relationship: negatively_regulates GO:0015668 ! Type III site-specific deoxyribonuclease activity

[Term]
id: GO:0032083
name: negative regulation of Type IV site-specific deoxyribonuclease activity
namespace: biological_process
def: "Any process that stops or reduces the rate of Type IV restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah, GOC:tb]
synonym: "down regulation of Type IV restriction endodeoxyribonuclease activity" EXACT []
synonym: "down-regulation of Type IV restriction endodeoxyribonuclease activity" EXACT []
synonym: "downregulation of Type IV restriction endodeoxyribonuclease activity" EXACT []
synonym: "inhibition of Type IV restriction endodeoxyribonuclease activity" NARROW []
synonym: "negative regulation of Type IV restriction endodeoxyribonuclease activity" EXACT [GOC:dph, GOC:tb]
synonym: "Type IV restriction endodeoxyribonuclease inhibitor" RELATED []
synonym: "Type IV restriction enzyme inhibitor" RELATED []
is_a: GO:0032073 ! negative regulation of restriction endodeoxyribonuclease activity
is_a: GO:0032087 ! regulation of Type IV site-specific deoxyribonuclease activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032067 ! Type IV site-specific deoxyribonuclease activity
relationship: negatively_regulates GO:0032067 ! Type IV site-specific deoxyribonuclease activity

[Term]
id: GO:0032084
name: regulation of Type I site-specific deoxyribonuclease activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a Type I restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah]
synonym: "regulation of Type I restriction endodeoxyribonuclease activity" EXACT [GOC:dph]
synonym: "Type I restriction endodeoxyribonuclease regulator" RELATED []
synonym: "Type I restriction enzyme regulator" RELATED []
is_a: GO:0032072 ! regulation of restriction endodeoxyribonuclease activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009035 ! Type I site-specific deoxyribonuclease activity
relationship: regulates GO:0009035 ! Type I site-specific deoxyribonuclease activity

[Term]
id: GO:0032085
name: regulation of Type II site-specific deoxyribonuclease activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a Type II restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah]
synonym: "regulation of Type II restriction endodeoxyribonuclease activity" EXACT [GOC:dph]
synonym: "Type II restriction endodeoxyribonuclease regulator" RELATED []
synonym: "Type II restriction enzyme regulator" RELATED []
is_a: GO:0032072 ! regulation of restriction endodeoxyribonuclease activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009036 ! Type II site-specific deoxyribonuclease activity
relationship: regulates GO:0009036 ! Type II site-specific deoxyribonuclease activity

[Term]
id: GO:0032086
name: regulation of Type III site-specific deoxyribonuclease activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a Type III restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah]
synonym: "regulation of Type III restriction endoribonuclease activity" EXACT [GOC:dph]
synonym: "Type III restriction endodeoxyribonuclease regulator" RELATED []
synonym: "Type III restriction enzyme regulator" RELATED []
is_a: GO:0032072 ! regulation of restriction endodeoxyribonuclease activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0015668 ! Type III site-specific deoxyribonuclease activity
relationship: regulates GO:0015668 ! Type III site-specific deoxyribonuclease activity

[Term]
id: GO:0032087
name: regulation of Type IV site-specific deoxyribonuclease activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a Type IV restriction endodeoxyribonuclease activity." [GOC:mah]
synonym: "regulation of Type IV restriction endodeoxyribonuclease activity" EXACT [GOC:dph]
synonym: "Type IV restriction endodeoxyribonuclease regulator" RELATED []
synonym: "Type IV restriction enzyme regulator" RELATED []
is_a: GO:0032072 ! regulation of restriction endodeoxyribonuclease activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032067 ! Type IV site-specific deoxyribonuclease activity
relationship: regulates GO:0032067 ! Type IV site-specific deoxyribonuclease activity

[Term]
id: GO:0032088
name: negative regulation of NF-kappaB transcription factor activity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB." [GOC:dph, GOC:rl, GOC:tb]
synonym: "inhibition of NF-kappaB transcription factor" EXACT [GOC:dph, GOC:tb]
synonym: "NF-kappaB inhibitor" RELATED []
is_a: GO:0043433 ! negative regulation of sequence-specific DNA binding transcription factor activity

[Term]
id: GO:0032089
name: NACHT domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a NACHT (NAIP, CIITA, HET-E and TP1) domain. The NACHT domain consists of seven distinct conserved motifs, including an ATP/GTPase specific P-loop, a Mg(2+)-binding site and five more specific motifs." [GOC:rl]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0032090
name: Pyrin domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a Pyrin (PAAD/DAPIN) domain, a protein-protein interaction domain that has the same fold as the Death domain." [GOC:rl]
synonym: "DAPIN domain binding" EXACT []
synonym: "PAAD domain binding" EXACT []
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0032091
name: negative regulation of protein binding
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation of protein binding" EXACT []
synonym: "down-regulation of protein binding" EXACT []
synonym: "downregulation of protein binding" EXACT []
synonym: "inhibition of protein binding" NARROW []
is_a: GO:0043393 ! regulation of protein binding
is_a: GO:0051100 ! negative regulation of binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0005515 ! protein binding
relationship: negatively_regulates GO:0005515 ! protein binding

[Term]
id: GO:0032092
name: positive regulation of protein binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein binding." [GOC:mah]
subset: gosubset_prok
synonym: "activation of protein binding" NARROW []
synonym: "stimulation of protein binding" NARROW []
synonym: "up regulation of protein binding" EXACT []
synonym: "up-regulation of protein binding" EXACT []
synonym: "upregulation of protein binding" EXACT []
is_a: GO:0043393 ! regulation of protein binding
is_a: GO:0051099 ! positive regulation of binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0005515 ! protein binding
relationship: positively_regulates GO:0005515 ! protein binding

[Term]
id: GO:0032093
name: SAM domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a SAM (Sterile Alpha Motif) domain, which is a 70-amino acid protein sequence that participates in protein-protein, protein-lipid, and protein-RNA interactions and is conserved from lower to higher eukaryotes." [GOC:mcc, PMID:16337230]
synonym: "Sterile Alpha Motif domain binding" EXACT []
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0032094
name: response to food
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a food stimulus; food is anything which, when taken into the body, serves to nourish or build up the tissues or to supply body heat." [GOC:add, ISBN:0721601464]
is_a: GO:0031667 ! response to nutrient levels
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0032095
name: regulation of response to food
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a response to a food stimulus." [GOC:add]
is_a: GO:0032107 ! regulation of response to nutrient levels
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032094 ! response to food
relationship: regulates GO:0032094 ! response to food

[Term]
id: GO:0032096
name: negative regulation of response to food
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a food stimulus." [GOC:add]
synonym: "down regulation of response to food" EXACT []
synonym: "down-regulation of response to food" EXACT []
synonym: "downregulation of response to food" EXACT []
synonym: "inhibition of response to food" NARROW []
is_a: GO:0032095 ! regulation of response to food
is_a: GO:0032108 ! negative regulation of response to nutrient levels
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032094 ! response to food
relationship: negatively_regulates GO:0032094 ! response to food

[Term]
id: GO:0032097
name: positive regulation of response to food
namespace: biological_process
def: "Any process that activates, maintains, or increases the rate of a response to a food stimulus." [GOC:add]
synonym: "activation of response to food" NARROW []
synonym: "stimulation of response to food" NARROW []
synonym: "up regulation of response to food" EXACT []
synonym: "up-regulation of response to food" EXACT []
synonym: "upregulation of response to food" EXACT []
is_a: GO:0032095 ! regulation of response to food
is_a: GO:0032109 ! positive regulation of response to nutrient levels
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032094 ! response to food
relationship: positively_regulates GO:0032094 ! response to food

[Term]
id: GO:0032098
name: regulation of appetite
namespace: biological_process
def: "Any process which modulates appetite, the desire or physical craving for food." [GOC:add]
synonym: "regulation of hunger" RELATED []
is_a: GO:0065008 ! regulation of biological quality
relationship: part_of GO:0031667 ! response to nutrient levels

[Term]
id: GO:0032099
name: negative regulation of appetite
namespace: biological_process
def: "Any process that reduces appetite." [GOC:add]
synonym: "appetite suppression" RELATED []
synonym: "down regulation of appetite" EXACT []
synonym: "down-regulation of appetite" EXACT []
synonym: "downregulation of appetite" EXACT []
synonym: "inhibition of appetite" NARROW []
synonym: "negative regulation of hunger" RELATED []
is_a: GO:0032096 ! negative regulation of response to food
is_a: GO:0032098 ! regulation of appetite

[Term]
id: GO:0032100
name: positive regulation of appetite
namespace: biological_process
def: "Any process that increases appetite." [GOC:add]
synonym: "activation of appetite" NARROW []
synonym: "appetite stimulation" RELATED []
synonym: "positive regulation of hunger" RELATED []
synonym: "stimulation of appetite" NARROW []
synonym: "up regulation of appetite" EXACT []
synonym: "up-regulation of appetite" EXACT []
synonym: "upregulation of appetite" EXACT []
is_a: GO:0032097 ! positive regulation of response to food
is_a: GO:0032098 ! regulation of appetite

[Term]
id: GO:0032101
name: regulation of response to external stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a response to an external stimulus." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
is_a: GO:0048583 ! regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009605 ! response to external stimulus
relationship: regulates GO:0009605 ! response to external stimulus

[Term]
id: GO:0032102
name: negative regulation of response to external stimulus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
synonym: "down regulation of response to external stimulus" EXACT []
synonym: "down-regulation of response to external stimulus" EXACT []
synonym: "downregulation of response to external stimulus" EXACT []
synonym: "inhibition of response to external stimulus" NARROW []
is_a: GO:0032101 ! regulation of response to external stimulus
is_a: GO:0048585 ! negative regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009605 ! response to external stimulus
relationship: negatively_regulates GO:0009605 ! response to external stimulus

[Term]
id: GO:0032103
name: positive regulation of response to external stimulus
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of a response to an external stimulus." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
synonym: "activation of response to external stimulus" NARROW []
synonym: "stimulation of response to external stimulus" NARROW []
synonym: "up regulation of response to external stimulus" EXACT []
synonym: "up-regulation of response to external stimulus" EXACT []
synonym: "upregulation of response to external stimulus" EXACT []
is_a: GO:0032101 ! regulation of response to external stimulus
is_a: GO:0048584 ! positive regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009605 ! response to external stimulus
relationship: positively_regulates GO:0009605 ! response to external stimulus

[Term]
id: GO:0032104
name: regulation of response to extracellular stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a response to an extracellular stimulus." [GOC:mah]
is_a: GO:0032101 ! regulation of response to external stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009991 ! response to extracellular stimulus
relationship: regulates GO:0009991 ! response to extracellular stimulus

[Term]
id: GO:0032105
name: negative regulation of response to extracellular stimulus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an extracellular stimulus." [GOC:mah]
synonym: "down regulation of response to extracellular stimulus" EXACT []
synonym: "down-regulation of response to extracellular stimulus" EXACT []
synonym: "downregulation of response to extracellular stimulus" EXACT []
synonym: "inhibition of response to extracellular stimulus" NARROW []
is_a: GO:0032102 ! negative regulation of response to external stimulus
is_a: GO:0032104 ! regulation of response to extracellular stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009991 ! response to extracellular stimulus
relationship: negatively_regulates GO:0009991 ! response to extracellular stimulus

[Term]
id: GO:0032106
name: positive regulation of response to extracellular stimulus
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of a response to an extracellular stimulus." [GOC:mah]
synonym: "activation of response to extracellular stimulus" NARROW []
synonym: "stimulation of response to extracellular stimulus" NARROW []
synonym: "up regulation of response to extracellular stimulus" EXACT []
synonym: "up-regulation of response to extracellular stimulus" EXACT []
synonym: "upregulation of response to extracellular stimulus" EXACT []
is_a: GO:0032103 ! positive regulation of response to external stimulus
is_a: GO:0032104 ! regulation of response to extracellular stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009991 ! response to extracellular stimulus
relationship: positively_regulates GO:0009991 ! response to extracellular stimulus

[Term]
id: GO:0032107
name: regulation of response to nutrient levels
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a response to nutrient levels." [GOC:mah]
is_a: GO:0032104 ! regulation of response to extracellular stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031667 ! response to nutrient levels
relationship: regulates GO:0031667 ! response to nutrient levels

[Term]
id: GO:0032108
name: negative regulation of response to nutrient levels
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to nutrient levels." [GOC:mah]
synonym: "down regulation of response to nutrient levels" EXACT []
synonym: "down-regulation of response to nutrient levels" EXACT []
synonym: "downregulation of response to nutrient levels" EXACT []
synonym: "inhibition of response to nutrient levels" NARROW []
is_a: GO:0032105 ! negative regulation of response to extracellular stimulus
is_a: GO:0032107 ! regulation of response to nutrient levels
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0031667 ! response to nutrient levels
relationship: negatively_regulates GO:0031667 ! response to nutrient levels

[Term]
id: GO:0032109
name: positive regulation of response to nutrient levels
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a response to nutrient levels." [GOC:mah]
synonym: "activation of response to nutrient levels" NARROW []
synonym: "stimulation of response to nutrient levels" NARROW []
synonym: "up regulation of response to nutrient levels" EXACT []
synonym: "up-regulation of response to nutrient levels" EXACT []
synonym: "upregulation of response to nutrient levels" EXACT []
is_a: GO:0032106 ! positive regulation of response to extracellular stimulus
is_a: GO:0032107 ! regulation of response to nutrient levels
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0031667 ! response to nutrient levels
relationship: positively_regulates GO:0031667 ! response to nutrient levels

[Term]
id: GO:0032110
name: regulation of protein histidine kinase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein histidine kinase activity." [GOC:mah]
is_a: GO:0045859 ! regulation of protein kinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004673 ! protein histidine kinase activity
relationship: regulates GO:0004673 ! protein histidine kinase activity

[Term]
id: GO:0032111
name: activation of protein histidine kinase activity
namespace: biological_process
def: "Any process that initiates the activity of an inactive protein histidine kinase." [GOC:mah]
synonym: "protein histidine kinase activator" RELATED []
is_a: GO:0010864 ! positive regulation of protein histidine kinase activity
is_a: GO:0032147 ! activation of protein kinase activity

[Term]
id: GO:0032112
name: negative regulation of protein histidine kinase activity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein histidine kinase activity." [GOC:mah]
synonym: "down regulation of protein histidine kinase activity" EXACT []
synonym: "down-regulation of protein histidine kinase activity" EXACT []
synonym: "downregulation of protein histidine kinase activity" EXACT []
synonym: "inhibition of protein histidine kinase activity" NARROW []
synonym: "protein histidine kinase inhibitor" RELATED []
is_a: GO:0006469 ! negative regulation of protein kinase activity
is_a: GO:0032110 ! regulation of protein histidine kinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004673 ! protein histidine kinase activity
relationship: negatively_regulates GO:0004673 ! protein histidine kinase activity

[Term]
id: GO:0032113
name: regulation of carbohydrate phosphatase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of carbohydrate phosphatase activity, the catalysis of the hydrolysis of phosphate from a carbohydrate phosphate." [GOC:mah]
is_a: GO:0010921 ! regulation of phosphatase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019203 ! carbohydrate phosphatase activity
relationship: regulates GO:0019203 ! carbohydrate phosphatase activity

[Term]
id: GO:0032114
name: regulation of glucose-6-phosphatase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glucose-6-phosphatase activity, the catalysis of the reaction: D-glucose 6-phosphate + H2O = D-glucose + phosphate." [GOC:kp]
is_a: GO:0032113 ! regulation of carbohydrate phosphatase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004346 ! glucose-6-phosphatase activity
relationship: regulates GO:0004346 ! glucose-6-phosphatase activity

[Term]
id: GO:0032115
name: sorbose reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucitol + NADP(+) = L-sorbose + H(+) + NADPH. The reaction may occur, to a minor extent, in the reverse direction." [EC:1.1.1.289, RHEA:14612]
synonym: "D-glucitol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.289]
synonym: "Sou1p" RELATED [EC:1.1.1.289]
xref: EC:1.1.1.289
xref: KEGG:R07346
xref: MetaCyc:1.1.1.289-RXN
xref: RHEA:14612
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0032116
name: SMC loading complex
namespace: cellular_component
def: "A protein complex required for the loading of a structural maintenance of chromosome (SMC) complex, such as cohesin, condensin or SMC5/SMC6, onto DNA. Appears to be eukaryotically conserved." [GOC:curators, GOC:vw, PMID:10882066]
synonym: "chromatin loading complex" RELATED [GOC:curators]
synonym: "cohesin loading complex" NARROW [GOC:curators]
synonym: "SCC2/SCC4 loading complex" NARROW [GOC:curators]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0032117
name: horsetail-astral microtubule array
namespace: cellular_component
def: "An array of astral microtubules that emanates from the spindle pole body during meiosis and facilitates horsetail nuclear movement." [GOC:mah, PMID:16111942]
synonym: "HAA" EXACT []
is_a: GO:0005818 ! aster
is_a: GO:0044448 ! cell cortex part
relationship: part_of GO:0030981 ! cortical microtubule cytoskeleton

[Term]
id: GO:0032118
name: horsetail-astral microtubule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the horsetail-astral array, a structure of astral microtubules that emanates from the spindle pole body during meiosis." [GOC:mah]
synonym: "horsetail-astral microtubule array organization" EXACT []
synonym: "horsetail-astral microtubule organisation" EXACT [GOC:mah]
synonym: "horsetail-astral microtubule organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0000226 ! microtubule cytoskeleton organization
is_a: GO:0071822 ! protein complex subunit organization
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0030989 ! dynein-driven meiotic oscillatory nuclear movement

[Term]
id: GO:0032119
name: sequestering of zinc ion
namespace: biological_process
def: "The process of binding or confining zinc ions such that they are separated from other components of a biological system." [GOC:mah]
is_a: GO:0051238 ! sequestering of metal ion
relationship: part_of GO:0006882 ! cellular zinc ion homeostasis

[Term]
id: GO:0032120
name: ascospore-type prospore membrane assembly
namespace: biological_process
def: "The process in which the nascent membrane forms at the meiotic outer plaque and grows until closure occurs and forespores, or prospores, are formed." [GOC:clt]
synonym: "forespore membrane biosynthesis" EXACT []
synonym: "forespore membrane formation" EXACT []
synonym: "FSM assembly" EXACT []
synonym: "FSM biosynthesis" EXACT []
synonym: "FSM formation" EXACT []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
is_a: GO:0071709 ! membrane assembly
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0031321 ! ascospore-type prospore assembly

[Term]
id: GO:0032121
name: meiotic attachment of telomeric heterochromatin to spindle pole body
namespace: biological_process
def: "The meiotic cell cycle process in which physical connections are formed between telomeric heterochromatin and the spindle pole body, facilitating bouquet formation." [GOC:pr, PMID:16615890]
synonym: "attachment of telomeres to spindle pole body" BROAD []
synonym: "attachment of telomeric chromatin to spindle pole body" BROAD []
is_a: GO:0007017 ! microtubule-based process
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0045141 ! meiotic telomere clustering

[Term]
id: GO:0032122
name: oral apparatus organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the oral apparatus. The oral apparatus is a funnel-like structure used by the cell to collect food and channel it to the cytostome, characteristic of ciliate protozoans." [PMID:10503189, PMID:6414830]
synonym: "oral apparatus morphogenesis" RELATED []
synonym: "oral apparatus organisation" EXACT [GOC:mah]
synonym: "oral apparatus organization and biogenesis" RELATED [GOC:mah]
synonym: "stomatogenesis" RELATED []
is_a: GO:0030030 ! cell projection organization

[Term]
id: GO:0032123
name: deep fiber
namespace: cellular_component
def: "Inward projections of the cytoskeletal structures of the oral apparatus, which form a fiber that extends past the cytostome into the cytoplasm." [PMID:10503189]
synonym: "deep fibre" EXACT []
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044463 ! cell projection part
relationship: part_of GO:0031912 ! oral apparatus

[Term]
id: GO:0032124
name: macronucleus organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the macronucleus." [GOC:dph, GOC:jl, GOC:mah, PMID:10503190]
synonym: "macronuclear organization" EXACT []
synonym: "macronuclear organization and biogenesis" RELATED [GOC:mah]
synonym: "macronucleus organisation" EXACT [GOC:mah]
is_a: GO:0006997 ! nucleus organization

[Term]
id: GO:0032125
name: micronucleus organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the micronucleus." [GOC:dph, GOC:jl, GOC:mah, PMID:10503190]
synonym: "micronuclear organization" EXACT []
synonym: "micronuclear organization and biogenesis" RELATED [GOC:mah]
synonym: "micronucleus organisation" EXACT [GOC:mah]
is_a: GO:0006997 ! nucleus organization

[Term]
id: GO:0032126
name: eisosome
namespace: cellular_component
def: "A cell part that is composed of the eisosome membrane or MCC domain, a furrow-like plasma membrane sub-domain and associated integral transmembrane proteins, and the proteins (eisosome filaments) that form a scaffolding lattice on the cytoplasmic face. Eisosomes broadly affect overall plasma membrane organization." [GOC:al, GOC:vw, PMID:16496001, PMID:22368779]
xref: Wikipedia:Eisosome
is_a: GO:0044464 ! cell part

[Term]
id: GO:0032127
name: dense core granule membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a dense core granule." [GOC:mah]
synonym: "dense core vesicle membrane" EXACT [GOC:kmv]
is_a: GO:0030667 ! secretory granule membrane
relationship: part_of GO:0031045 ! dense core granule

[Term]
id: GO:0032128
name: flocculation via extracellular polymer
namespace: biological_process
def: "Non-sexual aggregation of single-celled organisms mediated by polymers (polysaccharides, proteins, and/or nucleic acids) secreted into the extracellular environment." [DOI:10.1007/s002530051351, GOC:mah, PMID:14538073]
subset: gosubset_prok
synonym: "flocculation via EBF" EXACT []
synonym: "flocculation via extracellular biopolymeric flocculants" EXACT []
is_a: GO:0000128 ! flocculation

[Term]
id: GO:0032129
name: histone deacetylase activity (H3-K9 specific)
namespace: molecular_function
def: "Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + H2O = histone H3 L-lysine (position 9) + acetate. This reaction represents the removal of an acetyl group from lysine at position 9 of the histone H3 protein." [EC:3.5.1.17, RHEA:24551]
is_a: GO:0004407 ! histone deacetylase activity
relationship: part_of GO:0061647 ! histone H3-K9 modification
relationship: part_of GO:1990619 ! histone H3-K9 deacetylation

[Term]
id: GO:0032130
name: medial membrane band assembly
namespace: biological_process
def: "The assembly of a sterol-rich region of the plasma membrane at the cell surface overlying the contractile ring." [PMID:15517003]
synonym: "medial membrane band formation" RELATED [gOC:dph]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:1902410 ! mitotic cytokinetic process
relationship: part_of GO:0000281 ! mitotic cytokinesis

[Term]
id: GO:0032131
name: alkylated DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with alkylated residues in DNA." [GOC:mah]
is_a: GO:0003684 ! damaged DNA binding

[Term]
id: GO:0032132
name: O6-alkylguanine-DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with O6-alkylguanine adducts in DNA." [GOC:mah, PMID:16679453]
is_a: GO:0032131 ! alkylated DNA binding

[Term]
id: GO:0032133
name: chromosome passenger complex
namespace: cellular_component
def: "A eukaryotically conserved protein complex that localizes to kinetochores in early mitosis, the spindle mid-zone in anaphase B and to the telophase midbody. It has been proposed that the passenger complex coordinates various events based on its location to different structures during the course of mitosis. Complex members include the BIR-domain-containing protein Survivin, Aurora kinase, INCENP and Borealin." [GOC:vw, PMID:16824200, PMID:19570910]
synonym: "chromosomal passenger complex" EXACT [GOC:mcc]
synonym: "CPC" BROAD [GOC:mah]
synonym: "CPC complex" EXACT [GOC:vw]
is_a: GO:0005875 ! microtubule associated complex

[Term]
id: GO:0032135
name: DNA insertion or deletion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with double-stranded DNA containing insertions or deletions." [GOC:vk]
synonym: "DNA insertion binding" NARROW []
synonym: "insertion binding" EXACT []
is_a: GO:0030983 ! mismatched DNA binding

[Term]
id: GO:0032136
name: adenine/cytosine mispair binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with double-stranded DNA containing an A/C mispair." [GOC:vk]
synonym: "A/C mispair binding" EXACT [GOC:bf]
synonym: "C/A mispair binding" EXACT [GOC:bf]
synonym: "cytosine/adenine mispair binding" RELATED [GOC:bf]
is_a: GO:0030983 ! mismatched DNA binding

[Term]
id: GO:0032137
name: guanine/thymine mispair binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with double-stranded DNA containing a G/T mispair." [GOC:vk]
synonym: "G/T mispair binding" EXACT [GOC:bf]
synonym: "T/G mispair binding" EXACT [GOC:bf]
synonym: "thymine/guanine mispair binding" EXACT [GOC:bf]
is_a: GO:0030983 ! mismatched DNA binding

[Term]
id: GO:0032138
name: single base insertion or deletion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with double-stranded DNA containing a single base insertion or deletion." [GOC:vk]
synonym: "single base insertion binding" NARROW []
is_a: GO:0032135 ! DNA insertion or deletion binding

[Term]
id: GO:0032139
name: dinucleotide insertion or deletion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with double-stranded DNA containing a dinucleotide insertion or deletion." [GOC:vk]
synonym: "dinucleotide insertion binding" NARROW []
is_a: GO:0032135 ! DNA insertion or deletion binding

[Term]
id: GO:0032140
name: single adenine insertion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with double-stranded DNA containing a single adenine insertion or a deletion that results in an unpaired adenine." [GOC:mah, GOC:vk]
is_a: GO:0032138 ! single base insertion or deletion binding

[Term]
id: GO:0032141
name: single cytosine insertion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with double-stranded DNA containing a single cytosine insertion or a deletion that results in an unpaired cytosine." [GOC:mah, GOC:vk]
is_a: GO:0032138 ! single base insertion or deletion binding

[Term]
id: GO:0032142
name: single guanine insertion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with double-stranded DNA containing a single guanine insertion or a deletion that results in an unpaired guanine." [GOC:mah, GOC:vk]
is_a: GO:0032138 ! single base insertion or deletion binding

[Term]
id: GO:0032143
name: single thymine insertion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with double-stranded DNA containing a single thymine insertion or a deletion that results in an unpaired thymine." [GOC:mah, GOC:vk]
is_a: GO:0032138 ! single base insertion or deletion binding

[Term]
id: GO:0032144
name: 4-aminobutyrate transaminase complex
namespace: cellular_component
def: "A homodimeric protein complex that possesses 4-aminobutyrate transaminase activity." [GOC:mah, PMID:15528998]
synonym: "ABAT complex" EXACT []
synonym: "GABA transaminase complex" EXACT []
synonym: "GABA-T complex" EXACT []
is_a: GO:0044424 ! intracellular part
is_a: GO:1990234 ! transferase complex

[Term]
id: GO:0032145
name: succinate-semialdehyde dehydrogenase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with succinate-semialdehyde dehydrogenase." [GOC:mah]
synonym: "succinic semialdehyde dehydrogenase binding" EXACT []
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0032146
name: thiosulfate transmembrane-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + thiosulfate(out) = ADP + phosphate + thiosulfate(in)." [GOC:mlg]
is_a: GO:0015117 ! thiosulfate transmembrane transporter activity
is_a: GO:0043225 ! anion transmembrane-transporting ATPase activity

[Term]
id: GO:0032147
name: activation of protein kinase activity
namespace: biological_process
def: "Any process that initiates the activity of an inactive protein kinase." [GOC:mah]
synonym: "protein kinase activation" RELATED []
is_a: GO:0045860 ! positive regulation of protein kinase activity

[Term]
id: GO:0032148
name: activation of protein kinase B activity
namespace: biological_process
def: "Any process that initiates the activity of the inactive enzyme protein kinase B." [GOC:pg]
synonym: "protein kinase B activation" EXACT []
is_a: GO:0032147 ! activation of protein kinase activity

[Term]
id: GO:0032149
name: response to rhamnose
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rhamnose stimulus." [GOC:mlg]
synonym: "response to L-rhamnose stimulus" NARROW []
synonym: "response to rhamnose stimulus" EXACT [GOC:dos]
is_a: GO:0009746 ! response to hexose

[Term]
id: GO:0032150
name: ubiquinone biosynthetic process from chorismate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ubiquinone, beginning with the conversion of chorismate to 4-hydroxybenzoate." [GOC:mah, PMID:11583838]
is_a: GO:0006744 ! ubiquinone biosynthetic process
is_a: GO:0046417 ! chorismate metabolic process

[Term]
id: GO:0032151
name: mitotic septin complex
namespace: cellular_component
def: "A heterooligomeric septin complex that acts during mitotic cell division." [GOC:krc, PMID:16009555]
is_a: GO:0031105 ! septin complex

[Term]
id: GO:0032152
name: meiotic septin complex
namespace: cellular_component
def: "A heterooligomeric septin complex that acts during meiotic cell division." [GOC:krc, PMID:16009555]
is_a: GO:0031105 ! septin complex

[Term]
id: GO:0032153
name: cell division site
namespace: cellular_component
def: "The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles." [GOC:bf, GOC:imk, GOC:krc, GOC:ns, PMID:12101122, PMID:15380095, PMID:16983191, PMID:18165305]
comment: Note that this term refers to the future site of division in a cell that has not yet divided.
subset: goslim_pir
synonym: "cell division plane" EXACT []
is_a: GO:0044464 ! cell part

[Term]
id: GO:0032154
name: cleavage furrow
namespace: cellular_component
def: "In animal cells, the first sign of cleavage, or cytokinesis, is the appearance of a shallow groove in the cell surface near the old metaphase plate. A contractile ring containing actin and myosin is located just inside the plasma membrane at the location of the furrow. Ring contraction is associated with centripetal growth of the membrane that deepens the cleavage furrow and divides the cytoplasm of the two daughter cells. While the term 'cleavage furrow' was initially associated with animal cells, such a structure occurs in many other types of cells, including unicellular protists." [ISBN:0805319409]
xref: Wikipedia:Cleavage_furrow
is_a: GO:0032155 ! cell division site part
is_a: GO:0097610 ! cell surface furrow

[Term]
id: GO:0032155
name: cell division site part
namespace: cellular_component
def: "Any constituent part of the cell division plane, the eventual plane of cell division in a dividing cell." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: goantislim_grouping
subset: gocheck_do_not_annotate
synonym: "cell division plane part" EXACT []
is_a: GO:0044464 ! cell part
intersection_of: GO:0005575 ! cellular_component
intersection_of: part_of GO:0032153 ! cell division site
relationship: part_of GO:0032153 ! cell division site

[Term]
id: GO:0032156
name: septin cytoskeleton
namespace: cellular_component
def: "The part of the cytoskeleton (the internal framework of a cell) composed of septins and associated proteins. Includes septin cytoskeleton-associated complexes." [GOC:mah]
is_a: GO:0005856 ! cytoskeleton

[Term]
id: GO:0032157
name: prospore contractile ring
namespace: cellular_component
def: "A contractile ring, i.e. a cytoskeletal structure composed of actin filaments and myosin, that forms beneath the plasma membrane of the prospore envelope in meiotic cells in preparation for completing cytokinesis." [GOC:krc, PMID:16009555]
synonym: "actomyosin ring" RELATED []
synonym: "cytokinetic ring" RELATED []
synonym: "meiotic contractile ring" RELATED []
is_a: GO:0005826 ! actomyosin contractile ring
intersection_of: GO:0005826 ! actomyosin contractile ring
intersection_of: part_of GO:0042764 ! ascospore-type prospore
relationship: part_of GO:0042764 ! ascospore-type prospore

[Term]
id: GO:0032158
name: septin band
namespace: cellular_component
def: "A diffuse ring composed of a series of septin bars that run parallel to the long axis of the cell. This type of septin structure has been observed in a number of locations associated with polarized grown and/or deposition of new membrane, but not with cytokinesis, such as at the shmoo (mating projection) neck, at the junction between the mother cell and the germ tube (hypha) of a fungal cell growing filamentously." [GOC:krc, PMID:16151244]
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0032156 ! septin cytoskeleton

[Term]
id: GO:0032159
name: septin cap
namespace: cellular_component
def: "A faint structure formed of septins found at the leading edge of growth in germ tubes and hyphae in fungal cells growing filamentously. This cap of septins colocalizes with a region of the plasma membrane that is rich in ergosterol." [GOC:krc, PMID:16151244]
is_a: GO:0032156 ! septin cytoskeleton
is_a: GO:0044430 ! cytoskeletal part

[Term]
id: GO:0032160
name: septin filament array
namespace: cellular_component
def: "Arrays of septin filaments, or bars, found in a series of filamentous structures. Such structures have been observed in the prospore membrane during spore formation in S. cerevisiae and in the chlamydospore membrane during chlamydospore formation in C. albicans." [GOC:krc, PMID:16151244]
synonym: "septin bar" RELATED []
is_a: GO:0032156 ! septin cytoskeleton
is_a: GO:0044430 ! cytoskeletal part

[Term]
id: GO:0032161
name: cleavage apparatus septin structure
namespace: cellular_component
def: "Any of a series of structures composed of septins and septin-associated proteins localized to the cleavage plane which are involved in cytokinesis." [GOC:krc, PMID:12101122, PMID:15774761, PMID:16009555]
is_a: GO:0032155 ! cell division site part
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044448 ! cell cortex part
relationship: part_of GO:0032156 ! septin cytoskeleton

[Term]
id: GO:0032162
name: mating projection septin band
namespace: cellular_component
def: "A septin band, i.e. a diffuse ring composed of a series of septin bars running parallel to the long axis of the cell, located at the neck of a shmoo (mating projection)." [GOC:krc, GOC:mah, PMID:16151244]
is_a: GO:0032158 ! septin band
is_a: GO:0044463 ! cell projection part
intersection_of: GO:0032158 ! septin band
intersection_of: part_of GO:0005937 ! mating projection
relationship: part_of GO:0005937 ! mating projection

[Term]
id: GO:0032163
name: hyphal septin band
namespace: cellular_component
def: "A septin band, i.e. a diffuse ring composed of a series of septin bars running parallel to the long axis of the cell, located at the junction between the mother cell and the germ tube (hypha) of a fungal cell growing filamentously." [GOC:krc, GOC:mah, PMID:16151244]
is_a: GO:0032158 ! septin band

[Term]
id: GO:0032164
name: hyphal septin cap
namespace: cellular_component
def: "A faint structure formed of septins found at the leading edge of growth in hyphae of fungal cells growing filamentously. This cap of septins colocalizes with a region of the plasma membrane that is rich in ergosterol." [GOC:krc, PMID:16151244]
is_a: GO:0032159 ! septin cap

[Term]
id: GO:0032165
name: prospore septin filament array
namespace: cellular_component
def: "Arrays of septin filaments, or bars, found in a series of filamentous structures; observed in the prospore membrane during spore formation." [GOC:krc, PMID:16151244]
is_a: GO:0032160 ! septin filament array

[Term]
id: GO:0032166
name: chlamydospore septin filament array
namespace: cellular_component
def: "Arrays of septin filaments, or bars, found in a series of filamentous structures. Observed in the chlamydospore membrane during chlamydospore formation." [GOC:krc, PMID:16151244]
is_a: GO:0032160 ! septin filament array

[Term]
id: GO:0032167
name: obsolete septin patch
namespace: cellular_component
def: "OBSOLETE. An amorphous-appearing accumulation of septin proteins at the future site of cytokinesis." [PMID:16009555]
comment: This term was made obsolete because it was added in error; it does not refer to a normal subcellular structure.
synonym: "septin patch" EXACT []
is_obsolete: true

[Term]
id: GO:0032168
name: hyphal septin ring
namespace: cellular_component
def: "A tight ring-shaped structure that forms in the division plane within hyphae of filamentous fungi at sites where a septum will form; composed of septins as well as septin-associated proteins." [GOC:krc, GOC:mah, PMID:16151244]
is_a: GO:0005940 ! septin ring

[Term]
id: GO:0032169
name: prospore septin ring
namespace: cellular_component
def: "A tight ring-shaped structure that forms in the division plane at the site of cytokinesis in a prospore; composed of septins as well as septin-associated proteins." [GOC:krc, GOC:mah, PMID:16151244]
is_a: GO:0005940 ! septin ring
is_a: GO:0032161 ! cleavage apparatus septin structure
intersection_of: GO:0005940 ! septin ring
intersection_of: part_of GO:0042764 ! ascospore-type prospore
relationship: part_of GO:0042764 ! ascospore-type prospore

[Term]
id: GO:0032170
name: pseudohyphal septin ring
namespace: cellular_component
def: "A tight ring-shaped structure that forms in the division plane at the junction between the mother cell and a pseudohyphal projection; composed of septins as well as septin-associated proteins." [GOC:krc, GOC:mah, PMID:16151244]
is_a: GO:0005940 ! septin ring

[Term]
id: GO:0032171
name: germ tube septin cap
namespace: cellular_component
def: "A faint structure formed of septins found at the leading edge of growth in germ tubes of fungal cells growing filamentously. This cap of septins colocalizes with a region of the plasma membrane that is rich in ergosterol." [GOC:krc, PMID:16151244]
is_a: GO:0032159 ! septin cap
intersection_of: GO:0032159 ! septin cap
intersection_of: part_of GO:0032179 ! germ tube
relationship: part_of GO:0032179 ! germ tube

[Term]
id: GO:0032172
name: germ tube septin ring
namespace: cellular_component
def: "A tight ring-shaped structure that forms in the division plane within the germ tube of filamentous fungi at sites where a septum will form; composed of septins as well as septin-associated proteins." [GOC:krc, PMID:16151244]
is_a: GO:0005940 ! septin ring
intersection_of: GO:0005940 ! septin ring
intersection_of: part_of GO:0032179 ! germ tube
relationship: part_of GO:0032179 ! germ tube

[Term]
id: GO:0032173
name: septin collar
namespace: cellular_component
def: "A tubular, hourglass-shaped structure composed of highly ordered arrays of septin filaments; in budding yeast cells, the septin collar forms from the initial septin ring by expanding into the daughter cell." [GOC:krc, PMID:16009555, PMID:16151244]
is_a: GO:0032156 ! septin cytoskeleton
is_a: GO:0044430 ! cytoskeletal part

[Term]
id: GO:0032174
name: cellular bud neck septin collar
namespace: cellular_component
def: "A tubular structure with flared ends, shaped like an hourglass and composed of highly ordered arrays of septin filaments, that forms at the bud neck of a dividing cell. In S. cerevisiae, this structure is located at the bud neck throughout most of the cell cycle and the septins are fixed within the structure, not exchanging with soluble septins. This septin structure acts as a scaffold for other proteins that function at the bud neck." [GOC:krc, PMID:16009555]
is_a: GO:0000399 ! cellular bud neck septin structure
is_a: GO:0032161 ! cleavage apparatus septin structure
is_a: GO:0032173 ! septin collar
intersection_of: GO:0032173 ! septin collar
intersection_of: part_of GO:0005935 ! cellular bud neck
relationship: part_of GO:0005935 ! cellular bud neck

[Term]
id: GO:0032175
name: mating projection septin ring
namespace: cellular_component
def: "A septin ring, i.e. a ring-shaped structure composed of septins and septin-associated proteins, located at the neck of a shmoo (mating projection). The septin ring in the neck of a shmoo may act as a barrier to localize mating factors in the shmoo tip." [GOC:krc, GOC:mah, PMID:16151244]
is_a: GO:0005940 ! septin ring
is_a: GO:0044463 ! cell projection part
intersection_of: GO:0005940 ! septin ring
intersection_of: part_of GO:0005937 ! mating projection
relationship: part_of GO:0005937 ! mating projection

[Term]
id: GO:0032176
name: split septin rings
namespace: cellular_component
def: "A pair of rings that flank the site of cell division, formed by splitting of the septin ring (or collar) prior to cytokinesis; this double ring structure is thought to trap proteins needed for cytokinesis or the formation of the new membrane or cell wall between the two septin rings. Split septin rings are known to occur in budding yeast cells and probably occur in other cell types as well." [GOC:krc, PMID:16009555, PMID:16151244]
is_a: GO:0032156 ! septin cytoskeleton
is_a: GO:0044430 ! cytoskeletal part

[Term]
id: GO:0032177
name: cellular bud neck split septin rings
namespace: cellular_component
def: "Two separate septin rings that are formed from the septin collar at the time of cytokinesis in cells that divide by budding. These two rings are thought to delineate a special compartment in which factors involved in cytokinesis are concentrated." [GOC:krc, PMID:16009555]
is_a: GO:0000399 ! cellular bud neck septin structure
is_a: GO:0032161 ! cleavage apparatus septin structure
is_a: GO:0032176 ! split septin rings
intersection_of: GO:0032176 ! split septin rings
intersection_of: part_of GO:0005935 ! cellular bud neck
relationship: part_of GO:0005935 ! cellular bud neck

[Term]
id: GO:0032178
name: medial membrane band
namespace: cellular_component
def: "A sterol-rich region of the plasma membrane which forms at the cell surface overlying the contractile ring and spreads into the invaginating plasma membrane surrounding the septum." [PMID:15517003]
synonym: "sterol-rich membrane band" RELATED []
is_a: GO:0032155 ! cell division site part
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0032179
name: germ tube
namespace: cellular_component
def: "The slender tubular outgrowth first produced by most spores in germination." [ISBN:0877799148]
subset: goslim_pir
xref: Wikipedia:Germ_tube
is_a: GO:0044464 ! cell part

[Term]
id: GO:0032180
name: ubiquinone biosynthetic process from tyrosine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ubiquinone, beginning with the conversion of tyrosine to 4-hydroxybenzoate." [GOC:mah, PMID:11583838]
is_a: GO:0006570 ! tyrosine metabolic process
is_a: GO:0006744 ! ubiquinone biosynthetic process

[Term]
id: GO:0032181
name: dinucleotide repeat insertion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with double-stranded DNA containing a dinucleotide repeat insertion or a deletion resulting in unpaired dinucleotide repeats." [GOC:mah, GOC:vk]
is_a: GO:0032139 ! dinucleotide insertion or deletion binding

[Term]
id: GO:0032182
name: ubiquitin-like protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a small conjugating protein such as ubiquitin or a ubiquitin-like protein." [GOC:mah]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_yeast
synonym: "small conjugating protein binding" EXACT [GOC:dph]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0032183
name: SUMO binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the small ubiquitin-like protein SUMO." [GOC:mah]
synonym: "Smt3 binding" RELATED []
synonym: "Smt3 monomer binding" NARROW []
is_a: GO:0032182 ! ubiquitin-like protein binding

[Term]
id: GO:0032184
name: SUMO polymer binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a polymer of the small ubiquitin-like protein SUMO." [GOC:mah]
synonym: "Smt3 polymer binding" EXACT []
is_a: GO:0032183 ! SUMO binding

[Term]
id: GO:0032185
name: septin cytoskeleton organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising septin complexes and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]
subset: gosubset_prok
synonym: "septin cytoskeleton organisation" EXACT [GOC:mah]
synonym: "septin cytoskeleton organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0007010 ! cytoskeleton organization

[Term]
id: GO:0032186
name: cellular bud neck septin ring organization
namespace: biological_process
def: "Control of the formation, spatial distribution, and breakdown of a septin ring located at the bud neck." [GOC:mah]
synonym: "cellular bud neck septin ring organisation" EXACT [GOC:mah]
is_a: GO:0031106 ! septin ring organization
is_a: GO:1902589 ! single-organism organelle organization
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:0000281 ! mitotic cytokinesis
relationship: part_of GO:0007105 ! cytokinesis, site selection

[Term]
id: GO:0032187
name: actomyosin contractile ring localization
namespace: biological_process
def: "The process in which a contractile ring is assembled and/or maintained in a specific location, in the context of cytokinesis that takes place as part of a cell cycle." [GOC:mah]
synonym: "contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:mah]
synonym: "contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:mah, GOC:vw]
is_a: GO:0036214 ! contractile ring localization
is_a: GO:1902580 ! single-organism cellular localization
relationship: part_of GO:0061640 ! cytoskeleton-dependent cytokinesis

[Term]
id: GO:0032188
name: establishment of actomyosin contractile ring localization
namespace: biological_process
def: "The process in which a contractile ring is assembled in a specific location as part of a process of cell cycle cytokinesis." [GOC:mah]
synonym: "actomyosin ring positioning" RELATED [GOC:mah]
synonym: "contractile ring positioning" BROAD [GOC:mah]
synonym: "cytokinesis site selection by contractile ring positioning" EXACT [GOC:mah, GOC:vw]
synonym: "establishment of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:mah]
synonym: "establishment of contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:mah, GOC:vw]
synonym: "establishment of contractile ring localization involved in cytokinesis during cell cycle" RELATED [GOC:dph, GOC:tb]
is_a: GO:0032187 ! actomyosin contractile ring localization
relationship: part_of GO:0007105 ! cytokinesis, site selection

[Term]
id: GO:0032189
name: maintenance of actomyosin contractile ring localization
namespace: biological_process
def: "Any process in which an actomyosin contractile ring is maintained in a location and prevented from moving elsewhere." [GOC:mah]
synonym: "cytokinetic ring anchoring" RELATED []
synonym: "maintenance of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:mah]
synonym: "maintenance of contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:mah, GOC:vw]
synonym: "maintenance of contractile ring localization involved in cytokinesis during cell cycle" RELATED [GOC:dph, GOC:tb]
is_a: GO:0032187 ! actomyosin contractile ring localization
relationship: part_of GO:0031566 ! actomyosin contractile ring maintenance

[Term]
id: GO:0032190
name: acrosin binding
namespace: molecular_function
alt_id: GO:0032191
alt_id: GO:0032192
def: "Interacting selectively and non-covalently with acrosin, a protein that is found in the acrosomes of sperm and possesses protease and carbohydrate binding activities." [GOC:mah, PMID:12398221]
synonym: "acrosin heavy chain binding" NARROW []
synonym: "acrosin light chain binding" NARROW []
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0032193
name: ubiquinone biosynthetic process via 2-polyprenylphenol
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ubiquinone, via the intermediates 2-polyprenylphenol and 2-polyprenyl-6-hydroxyphenol." [GOC:mah, PMID:11583838]
is_a: GO:0006744 ! ubiquinone biosynthetic process

[Term]
id: GO:0032194
name: ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ubiquinone, via the intermediates 3,4-dihydroxy-5-polyprenylbenzoate and 3-methoxy-4-hydroxy-5-polyprenylbenzoate." [GOC:mah, PMID:11583838]
is_a: GO:0006744 ! ubiquinone biosynthetic process

[Term]
id: GO:0032195
name: post-lysosomal vacuole
namespace: cellular_component
def: "A membrane-bounded intracellular vesicle formed late in the endocytic pathway when the pH in the vacuole becomes neutral prior to exocytosis." [GOC:pf, PMID:9276759, PMID:9394012]
is_a: GO:0005773 ! vacuole
is_a: GO:0030139 ! endocytic vesicle

[Term]
id: GO:0032196
name: transposition
namespace: biological_process
def: "Any process involved in mediating the movement of discrete segments of DNA between nonhomologous sites." [GOC:jp, ISBN:1555812090]
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
xref: Wikipedia:Transposon
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0032197
name: transposition, RNA-mediated
namespace: biological_process
alt_id: GO:0006319
alt_id: GO:0006320
alt_id: GO:0006321
alt_id: GO:0006322
def: "Any process involved in a type of transpositional recombination which occurs via an RNA intermediate." [GOC:jp, ISBN:1555812090]
subset: gosubset_prok
synonym: "Class I transposition" EXACT []
synonym: "retrotransposition" EXACT []
synonym: "retrotransposon transposition" EXACT []
synonym: "RNA-mediated transposition" EXACT [GOC:dph, GOC:tb]
synonym: "Tf transposition" NARROW []
synonym: "Ty element transposition" NARROW []
synonym: "Ty1 element transposition" NARROW []
synonym: "Ty2 element transposition" NARROW []
synonym: "Ty3 element transposition" NARROW []
xref: Wikipedia:Transposon##Class_I\:_Retrotransposons
is_a: GO:0032196 ! transposition

[Term]
id: GO:0032198
name: MITE transposition
namespace: biological_process
def: "Any process involved in the transposition of miniature inverted-repeat transposable elements (MITEs)." [GOC:jp, ISBN:1555812090]
synonym: "Class III transposition" EXACT []
is_a: GO:0032196 ! transposition

[Term]
id: GO:0032199
name: reverse transcription involved in RNA-mediated transposition
namespace: biological_process
def: "The synthesis of DNA from an RNA transposon intermediate." [GOC:jp, GOC:txnOH, ISBN:1555812090]
synonym: "reverse transcription during retrotransposition" EXACT []
is_a: GO:0001171 ! reverse transcription
intersection_of: GO:0001171 ! reverse transcription
intersection_of: part_of GO:0032197 ! transposition, RNA-mediated
relationship: part_of GO:0032197 ! transposition, RNA-mediated

[Term]
id: GO:0032200
name: telomere organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins." [GOC:dph, GOC:jl, GOC:mah]
subset: goslim_pombe
subset: goslim_yeast
synonym: "chromosome organization, telomeric" EXACT []
synonym: "organization of chromosome, telomeric region" EXACT []
synonym: "telomere organisation" EXACT [GOC:mah]
synonym: "telomere organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0051276 ! chromosome organization

[Term]
id: GO:0032201
name: telomere maintenance via semi-conservative replication
namespace: biological_process
def: "The process in which telomeric DNA is synthesized semi-conservatively by the conventional replication machinery and telomeric accessory factors as part of cell cycle DNA replication." [GOC:vw, PMID:16598261]
synonym: "equal telomere replication" RELATED []
synonym: "telomeric fork progression" NARROW []
synonym: "telomeric replication fork progression" NARROW []
xref: Reactome:REACT_103027 "Telomere C-strand (Lagging Strand) Synthesis, Caenorhabditis elegans"
xref: Reactome:REACT_103769 "Telomere C-strand (Lagging Strand) Synthesis, Arabidopsis thaliana"
xref: Reactome:REACT_104087 "Telomere C-strand (Lagging Strand) Synthesis, Schizosaccharomyces pombe"
xref: Reactome:REACT_105111 "Telomere C-strand (Lagging Strand) Synthesis, Bos taurus"
xref: Reactome:REACT_107728 "Telomere C-strand (Lagging Strand) Synthesis, Danio rerio"
xref: Reactome:REACT_28518 "Telomere C-strand (Lagging Strand) Synthesis, Dictyostelium discoideum"
xref: Reactome:REACT_31770 "Telomere C-strand (Lagging Strand) Synthesis, Drosophila melanogaster"
xref: Reactome:REACT_32149 "Telomere C-strand (Lagging Strand) Synthesis, Rattus norvegicus"
xref: Reactome:REACT_32752 "Telomere C-strand (Lagging Strand) Synthesis, Xenopus tropicalis"
xref: Reactome:REACT_77337 "Telomere C-strand (Lagging Strand) Synthesis, Taeniopygia guttata"
xref: Reactome:REACT_77927 "Telomere C-strand (Lagging Strand) Synthesis, Plasmodium falciparum"
xref: Reactome:REACT_7961 "Telomere C-strand (Lagging Strand) Synthesis, Homo sapiens"
xref: Reactome:REACT_85491 "Telomere C-strand (Lagging Strand) Synthesis, Sus scrofa"
xref: Reactome:REACT_85661 "Telomere C-strand (Lagging Strand) Synthesis, Canis familiaris"
xref: Reactome:REACT_85706 "Telomere C-strand (Lagging Strand) Synthesis, Saccharomyces cerevisiae"
xref: Reactome:REACT_89693 "Telomere C-strand (Lagging Strand) Synthesis, Mus musculus"
xref: Reactome:REACT_91367 "Telomere C-strand (Lagging Strand) Synthesis, Oryza sativa"
xref: Reactome:REACT_97228 "Telomere C-strand (Lagging Strand) Synthesis, Gallus gallus"
is_a: GO:0010833 ! telomere maintenance via telomere lengthening
is_a: GO:0019725 ! cellular homeostasis
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0033260 ! nuclear DNA replication

[Term]
id: GO:0032202
name: telomere assembly
namespace: biological_process
def: "A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a telomere at a non-telomeric double-stranded DNA end. A telomere is a terminal region of a linear chromosome that includes telomeric DNA repeats and associated proteins." [GOC:mah, GOC:ns, PMID:11902675, PMID:8622671]
synonym: "telomere formation" EXACT []
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0032200 ! telomere organization

[Term]
id: GO:0032203
name: telomere formation via telomerase
namespace: biological_process
def: "A cellular process that results in the formation of a telomere at a non-telomeric double-stranded DNA end that involves the activity of a telomerase enzyme." [GOC:cjm, GOC:ns, PMID:11902675, PMID:8622671]
is_a: GO:0032202 ! telomere assembly
relationship: has_part GO:0003720 ! telomerase activity

[Term]
id: GO:0032204
name: regulation of telomere maintenance
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah]
is_a: GO:0032844 ! regulation of homeostatic process
is_a: GO:0033044 ! regulation of chromosome organization
is_a: GO:0051052 ! regulation of DNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000723 ! telomere maintenance
relationship: regulates GO:0000723 ! telomere maintenance

[Term]
id: GO:0032205
name: negative regulation of telomere maintenance
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah]
synonym: "down regulation of telomere maintenance" EXACT []
synonym: "down-regulation of telomere maintenance" EXACT []
synonym: "downregulation of telomere maintenance" EXACT []
synonym: "inhibition of telomere maintenance" NARROW []
is_a: GO:0032204 ! regulation of telomere maintenance
is_a: GO:0032845 ! negative regulation of homeostatic process
is_a: GO:0051053 ! negative regulation of DNA metabolic process
is_a: GO:2001251 ! negative regulation of chromosome organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000723 ! telomere maintenance
relationship: negatively_regulates GO:0000723 ! telomere maintenance

[Term]
id: GO:0032206
name: positive regulation of telomere maintenance
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah]
synonym: "activation of telomere maintenance" NARROW []
synonym: "stimulation of telomere maintenance" NARROW []
synonym: "up regulation of telomere maintenance" EXACT []
synonym: "up-regulation of telomere maintenance" EXACT []
synonym: "upregulation of telomere maintenance" EXACT []
is_a: GO:0032204 ! regulation of telomere maintenance
is_a: GO:0032846 ! positive regulation of homeostatic process
is_a: GO:0051054 ! positive regulation of DNA metabolic process
is_a: GO:2001252 ! positive regulation of chromosome organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000723 ! telomere maintenance
relationship: positively_regulates GO:0000723 ! telomere maintenance

[Term]
id: GO:0032207
name: regulation of telomere maintenance via recombination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a recombinational process involved in the maintenance of proper telomeric length." [GOC:mah]
is_a: GO:0000019 ! regulation of mitotic recombination
is_a: GO:0032204 ! regulation of telomere maintenance
is_a: GO:0072695 ! regulation of DNA recombination at telomere
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000722 ! telomere maintenance via recombination
relationship: regulates GO:0000722 ! telomere maintenance via recombination

[Term]
id: GO:0032208
name: negative regulation of telomere maintenance via recombination
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a recombinational process involved in the maintenance of proper telomeric length." [GOC:mah]
synonym: "down regulation of telomere maintenance via recombination" EXACT []
synonym: "down-regulation of telomere maintenance via recombination" EXACT []
synonym: "downregulation of telomere maintenance via recombination" EXACT []
synonym: "inhibition of telomere maintenance via recombination" NARROW []
is_a: GO:0032205 ! negative regulation of telomere maintenance
is_a: GO:0032207 ! regulation of telomere maintenance via recombination
is_a: GO:0045950 ! negative regulation of mitotic recombination
is_a: GO:0048239 ! negative regulation of DNA recombination at telomere
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000722 ! telomere maintenance via recombination
relationship: negatively_regulates GO:0000722 ! telomere maintenance via recombination

[Term]
id: GO:0032209
name: positive regulation of telomere maintenance via recombination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a recombinational process involved in the maintenance of proper telomeric length." [GOC:mah]
synonym: "activation of telomere maintenance via recombination" NARROW []
synonym: "stimulation of telomere maintenance via recombination" NARROW []
synonym: "up regulation of telomere maintenance via recombination" EXACT []
synonym: "up-regulation of telomere maintenance via recombination" EXACT []
synonym: "upregulation of telomere maintenance via recombination" EXACT []
is_a: GO:0032206 ! positive regulation of telomere maintenance
is_a: GO:0032207 ! regulation of telomere maintenance via recombination
is_a: GO:0045951 ! positive regulation of mitotic recombination
is_a: GO:0072696 ! positive regulation of DNA recombination at telomere
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000722 ! telomere maintenance via recombination
relationship: positively_regulates GO:0000722 ! telomere maintenance via recombination

[Term]
id: GO:0032210
name: regulation of telomere maintenance via telomerase
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah]
is_a: GO:0006275 ! regulation of DNA replication
is_a: GO:1904356 ! regulation of telomere maintenance via telomere lengthening
is_a: GO:2000278 ! regulation of DNA biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007004 ! telomere maintenance via telomerase
relationship: regulates GO:0007004 ! telomere maintenance via telomerase

[Term]
id: GO:0032211
name: negative regulation of telomere maintenance via telomerase
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah]
synonym: "down regulation of telomere maintenance via telomerase activity" EXACT []
synonym: "down-regulation of telomere maintenance via telomerase activity" EXACT []
synonym: "downregulation of telomere maintenance via telomerase activity" EXACT []
synonym: "inhibition of telomere maintenance via telomerase" NARROW []
is_a: GO:0008156 ! negative regulation of DNA replication
is_a: GO:0032210 ! regulation of telomere maintenance via telomerase
is_a: GO:1904357 ! negative regulation of telomere maintenance via telomere lengthening
is_a: GO:2000279 ! negative regulation of DNA biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007004 ! telomere maintenance via telomerase
relationship: negatively_regulates GO:0007004 ! telomere maintenance via telomerase

[Term]
id: GO:0032212
name: positive regulation of telomere maintenance via telomerase
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah]
synonym: "activation of telomere maintenance via telomerase" NARROW []
synonym: "stimulation of telomere maintenance via telomerase" NARROW []
synonym: "up regulation of telomere maintenance via telomerase activity" EXACT []
synonym: "up-regulation of telomere maintenance via telomerase activity" EXACT []
synonym: "upregulation of telomere maintenance via telomerase activity" EXACT []
is_a: GO:0032210 ! regulation of telomere maintenance via telomerase
is_a: GO:0045740 ! positive regulation of DNA replication
is_a: GO:1904358 ! positive regulation of telomere maintenance via telomere lengthening
is_a: GO:2000573 ! positive regulation of DNA biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007004 ! telomere maintenance via telomerase
relationship: positively_regulates GO:0007004 ! telomere maintenance via telomerase

[Term]
id: GO:0032213
name: regulation of telomere maintenance via semi-conservative replication
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the semi-conservative replication of telomeric DNA." [GOC:mah]
is_a: GO:0033262 ! regulation of nuclear cell cycle DNA replication
is_a: GO:1904356 ! regulation of telomere maintenance via telomere lengthening
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032201 ! telomere maintenance via semi-conservative replication
relationship: regulates GO:0032201 ! telomere maintenance via semi-conservative replication

[Term]
id: GO:0032214
name: negative regulation of telomere maintenance via semi-conservative replication
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the semi-conservative replication of telomeric DNA." [GOC:mah]
synonym: "down regulation of telomere maintenance via semi-conservative replication" EXACT []
synonym: "down-regulation of telomere maintenance via semi-conservative replication" EXACT []
synonym: "downregulation of telomere maintenance via semi-conservative replication" EXACT []
synonym: "inhibition of telomere maintenance via semi-conservative replication" NARROW []
is_a: GO:0032213 ! regulation of telomere maintenance via semi-conservative replication
is_a: GO:1902576 ! negative regulation of nuclear cell cycle DNA replication
is_a: GO:1904357 ! negative regulation of telomere maintenance via telomere lengthening
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032201 ! telomere maintenance via semi-conservative replication
relationship: negatively_regulates GO:0032201 ! telomere maintenance via semi-conservative replication

[Term]
id: GO:0032215
name: positive regulation of telomere maintenance via semi-conservative replication
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the semi-conservative replication of telomeric DNA." [GOC:mah]
synonym: "activation of telomere maintenance via semi-conservative replication" NARROW []
synonym: "stimulation of telomere maintenance via semi-conservative replication" NARROW []
synonym: "up regulation of telomere maintenance via semi-conservative replication" EXACT []
synonym: "up-regulation of telomere maintenance via semi-conservative replication" EXACT []
synonym: "upregulation of telomere maintenance via semi-conservative replication" EXACT []
is_a: GO:0010571 ! positive regulation of nuclear cell cycle DNA replication
is_a: GO:0032213 ! regulation of telomere maintenance via semi-conservative replication
is_a: GO:1904358 ! positive regulation of telomere maintenance via telomere lengthening
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032201 ! telomere maintenance via semi-conservative replication
relationship: positively_regulates GO:0032201 ! telomere maintenance via semi-conservative replication

[Term]
id: GO:0032216
name: glucosaminyl-phosphotidylinositol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: glucosaminyl-phosphotidylinositol + fatty acyl-CoA = glucosaminyl-acyl-phosphotidylinositol + CoA." [Reactome:REACT_1049.1]
synonym: "GPI-inositol acyltransferase" RELATED []
xref: EC:2.3.1.-
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0032217
name: riboflavin transporter activity
namespace: molecular_function
def: "Enables the directed movement of riboflavin into, out of or within a cell, or between cells. Riboflavin (vitamin B2) is a water-soluble B-complex vitamin, converted in the cell to FMN and FAD, cofactors required for the function of flavoproteins." [GOC:rn, PMID:16204239]
is_a: GO:0051183 ! vitamin transporter activity
relationship: part_of GO:0032218 ! riboflavin transport

[Term]
id: GO:0032218
name: riboflavin transport
namespace: biological_process
def: "The directed movement of riboflavin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Riboflavin (vitamin B2) is a water-soluble B-complex vitamin, converted in the cell to FMN and FAD, cofactors required for the function of flavoproteins." [GOC:rn, PMID:16204239]
is_a: GO:0015711 ! organic anion transport
is_a: GO:0051180 ! vitamin transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0032219
name: cell wall macromolecule catabolic process involved in cytogamy
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of macromolecules forming part of a cell wall that contribute to cytogamy." [GOC:mah]
synonym: "cell wall macromolecule catabolic process during cytogamy" RELATED [GOC:dph, GOC:tb]
is_a: GO:0016998 ! cell wall macromolecule catabolic process
is_a: GO:0022414 ! reproductive process
intersection_of: GO:0016998 ! cell wall macromolecule catabolic process
intersection_of: part_of GO:0000755 ! cytogamy
relationship: part_of GO:0000755 ! cytogamy

[Term]
id: GO:0032220
name: plasma membrane fusion involved in cytogamy
namespace: biological_process
def: "The joining of two or more lipid bilayer membranes that surround cells, that contributes to cytogamy." [GOC:mah]
synonym: "plasma membrane fusion during cytogamy" RELATED [GOC:dph, GOC:tb]
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0045026 ! plasma membrane fusion
intersection_of: GO:0045026 ! plasma membrane fusion
intersection_of: part_of GO:0000755 ! cytogamy
relationship: part_of GO:0000755 ! cytogamy

[Term]
id: GO:0032221
name: Rpd3S complex
namespace: cellular_component
alt_id: GO:0000509
def: "A eukaryotically conserved histone deacetylase complex which deacetylates histones preferentially in promoter regions. Composed of a catalytic histone deacetylase subunit, a chromodomain protein, a SIN3 family co-repressor, and a WD repeat protein (Clr6p, Alp13p, Pst2p, and Prw1p respectively in Schizosaccharomyces; Rpd3p, Sin3p, Ume1p, Rco1p and Eaf3 in Saccharomyces; homologs thereof in other species)." [GOC:vw, PMID:12773392, PMID:17450151]
synonym: "Clr6 histone deacetylase complex II'" EXACT [GOC:vw]
synonym: "Clr6S complex" EXACT [PMID:19040720]
synonym: "Rpd3C(S)" EXACT []
is_a: GO:0070822 ! Sin3-type complex

[Term]
id: GO:0032222
name: regulation of synaptic transmission, cholinergic
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine." [GOC:mah]
is_a: GO:0050804 ! modulation of synaptic transmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007271 ! synaptic transmission, cholinergic
relationship: regulates GO:0007271 ! synaptic transmission, cholinergic

[Term]
id: GO:0032223
name: negative regulation of synaptic transmission, cholinergic
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine." [GOC:mah]
synonym: "down regulation of synaptic transmission, cholinergic" EXACT []
synonym: "down-regulation of synaptic transmission, cholinergic" EXACT []
synonym: "downregulation of synaptic transmission, cholinergic" EXACT []
synonym: "inhibition of synaptic transmission, cholinergic" NARROW []
is_a: GO:0032222 ! regulation of synaptic transmission, cholinergic
is_a: GO:0050805 ! negative regulation of synaptic transmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007271 ! synaptic transmission, cholinergic
relationship: negatively_regulates GO:0007271 ! synaptic transmission, cholinergic

[Term]
id: GO:0032224
name: positive regulation of synaptic transmission, cholinergic
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine." [GOC:mah]
synonym: "activation of synaptic transmission, cholinergic" NARROW []
synonym: "stimulation of synaptic transmission, cholinergic" NARROW []
synonym: "up regulation of synaptic transmission, cholinergic" EXACT []
synonym: "up-regulation of synaptic transmission, cholinergic" EXACT []
synonym: "upregulation of synaptic transmission, cholinergic" EXACT []
is_a: GO:0032222 ! regulation of synaptic transmission, cholinergic
is_a: GO:0050806 ! positive regulation of synaptic transmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007271 ! synaptic transmission, cholinergic
relationship: positively_regulates GO:0007271 ! synaptic transmission, cholinergic

[Term]
id: GO:0032225
name: regulation of synaptic transmission, dopaminergic
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine." [GOC:mah]
is_a: GO:0050804 ! modulation of synaptic transmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001963 ! synaptic transmission, dopaminergic
relationship: regulates GO:0001963 ! synaptic transmission, dopaminergic

[Term]
id: GO:0032226
name: positive regulation of synaptic transmission, dopaminergic
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine." [GOC:mah]
synonym: "activation of synaptic transmission, dopaminergic" NARROW []
synonym: "stimulation of synaptic transmission, dopaminergic" NARROW []
synonym: "up regulation of synaptic transmission, dopaminergic" EXACT []
synonym: "up-regulation of synaptic transmission, dopaminergic" EXACT []
synonym: "upregulation of synaptic transmission, dopaminergic" EXACT []
is_a: GO:0032225 ! regulation of synaptic transmission, dopaminergic
is_a: GO:0050806 ! positive regulation of synaptic transmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001963 ! synaptic transmission, dopaminergic
relationship: positively_regulates GO:0001963 ! synaptic transmission, dopaminergic

[Term]
id: GO:0032227
name: negative regulation of synaptic transmission, dopaminergic
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine." [GOC:mah]
synonym: "down regulation of synaptic transmission, dopaminergic" EXACT []
synonym: "down-regulation of synaptic transmission, dopaminergic" EXACT []
synonym: "downregulation of synaptic transmission, dopaminergic" EXACT []
synonym: "inhibition of synaptic transmission, dopaminergic" NARROW []
is_a: GO:0032225 ! regulation of synaptic transmission, dopaminergic
is_a: GO:0050805 ! negative regulation of synaptic transmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001963 ! synaptic transmission, dopaminergic
relationship: negatively_regulates GO:0001963 ! synaptic transmission, dopaminergic

[Term]
id: GO:0032228
name: regulation of synaptic transmission, GABAergic
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA)." [GOC:mah]
is_a: GO:0050804 ! modulation of synaptic transmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051932 ! synaptic transmission, GABAergic
relationship: regulates GO:0051932 ! synaptic transmission, GABAergic

[Term]
id: GO:0032229
name: negative regulation of synaptic transmission, GABAergic
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA)." [GOC:mah]
synonym: "down regulation of synaptic transmission, GABAergic" EXACT []
synonym: "down-regulation of synaptic transmission, GABAergic" EXACT []
synonym: "downregulation of synaptic transmission, GABAergic" EXACT []
synonym: "inhibition of synaptic transmission, GABAergic" NARROW []
is_a: GO:0032228 ! regulation of synaptic transmission, GABAergic
is_a: GO:0050805 ! negative regulation of synaptic transmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051932 ! synaptic transmission, GABAergic
relationship: negatively_regulates GO:0051932 ! synaptic transmission, GABAergic

[Term]
id: GO:0032230
name: positive regulation of synaptic transmission, GABAergic
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA)." [GOC:mah]
synonym: "activation of synaptic transmission, GABAergic" NARROW []
synonym: "stimulation of synaptic transmission, GABAergic" NARROW []
synonym: "up regulation of synaptic transmission, GABAergic" EXACT []
synonym: "up-regulation of synaptic transmission, GABAergic" EXACT []
synonym: "upregulation of synaptic transmission, GABAergic" EXACT []
is_a: GO:0032228 ! regulation of synaptic transmission, GABAergic
is_a: GO:0050806 ! positive regulation of synaptic transmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051932 ! synaptic transmission, GABAergic
relationship: positively_regulates GO:0051932 ! synaptic transmission, GABAergic

[Term]
id: GO:0032231
name: regulation of actin filament bundle assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the assembly of actin filament bundles." [GOC:mah]
synonym: "regulation of actin cable assembly" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of actin filament bundle formation" RELATED [GOC:dph]
is_a: GO:0032956 ! regulation of actin cytoskeleton organization
is_a: GO:0044087 ! regulation of cellular component biogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051017 ! actin filament bundle assembly
relationship: regulates GO:0051017 ! actin filament bundle assembly

[Term]
id: GO:0032232
name: negative regulation of actin filament bundle assembly
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of actin filament bundles." [GOC:mah]
synonym: "down regulation of actin filament bundle formation" EXACT []
synonym: "down-regulation of actin filament bundle formation" EXACT []
synonym: "downregulation of actin filament bundle formation" EXACT []
synonym: "inhibition of actin filament bundle formation" NARROW []
is_a: GO:0032231 ! regulation of actin filament bundle assembly
is_a: GO:0051494 ! negative regulation of cytoskeleton organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051017 ! actin filament bundle assembly
relationship: negatively_regulates GO:0051017 ! actin filament bundle assembly

[Term]
id: GO:0032233
name: positive regulation of actin filament bundle assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles." [GOC:mah]
synonym: "activation of actin filament bundle formation" NARROW []
synonym: "stimulation of actin filament bundle formation" NARROW []
synonym: "up regulation of actin filament bundle formation" EXACT []
synonym: "up-regulation of actin filament bundle formation" EXACT []
synonym: "upregulation of actin filament bundle formation" EXACT []
is_a: GO:0032231 ! regulation of actin filament bundle assembly
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:0051495 ! positive regulation of cytoskeleton organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051017 ! actin filament bundle assembly
relationship: positively_regulates GO:0051017 ! actin filament bundle assembly

[Term]
id: GO:0032234
name: obsolete regulation of calcium ion transport via store-operated calcium channel activity
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the directed movement of calcium ions via a store-operated calcium channel." [GOC:bf, PMID:16582901]
comment: This term was made obsolete because it is ill-defined: channel activities are part of ion transport processes, and not the other way round.
synonym: "regulation of calcium ion transport via store-operated calcium channel activity" EXACT []
synonym: "regulation of calcium transport via store-operated calcium channel" EXACT []
synonym: "regulation of store-operated calcium channel activity" EXACT []
is_obsolete: true
consider: GO:0015279

[Term]
id: GO:0032235
name: obsolete negative regulation of calcium ion transport via store-operated calcium channel activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of calcium ions via a store-operated calcium channel." [GOC:bf, PMID:16582901]
comment: This term was made obsolete because it is ill-defined: channel activities are part of ion transport processes, and not the other way round.
synonym: "down regulation of calcium ion transport via store-operated calcium channel" EXACT []
synonym: "down-regulation of calcium ion transport via store-operated calcium channel" EXACT []
synonym: "downregulation of calcium ion transport via store-operated calcium channel" EXACT []
synonym: "inhibition of calcium ion transport via store-operated calcium channel" NARROW []
synonym: "negative regulation of calcium ion transport via store-operated calcium channel activity" EXACT []
synonym: "negative regulation of calcium transport via store-operated calcium channel" EXACT []
synonym: "negative regulation of store-operated calcium channel activity" EXACT []
is_obsolete: true
consider: GO:0015279

[Term]
id: GO:0032236
name: obsolete positive regulation of calcium ion transport via store-operated calcium channel activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions via a store-operated calcium channel." [GOC:bf, PMID:16582901]
comment: This term was made obsolete because it is ill-defined: channel activities are part of ion transport processes, and not the other way round.
synonym: "activation of calcium ion transport via store-operated calcium channel" NARROW []
synonym: "positive regulation of calcium ion transport via store-operated calcium channel activity" EXACT []
synonym: "positive regulation of calcium transport via store-operated calcium channel" EXACT []
synonym: "positive regulation of store-operated calcium channel activity" EXACT []
synonym: "stimulation of calcium ion transport via store-operated calcium channel" NARROW []
synonym: "up regulation of calcium ion transport via store-operated calcium channel" EXACT []
synonym: "up-regulation of calcium ion transport via store-operated calcium channel" EXACT []
synonym: "upregulation of calcium ion transport via store-operated calcium channel" EXACT []
is_obsolete: true
consider: GO:0015279

[Term]
id: GO:0032237
name: activation of store-operated calcium channel activity
namespace: biological_process
def: "A process that initiates the activity of an inactive store-operated calcium channel." [GOC:mah]
is_a: GO:1901341 ! positive regulation of store-operated calcium channel activity

[Term]
id: GO:0032238
name: adenosine transport
namespace: biological_process
def: "The directed movement of adenosine, adenine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
subset: gosubset_prok
is_a: GO:0015858 ! nucleoside transport

[Term]
id: GO:0032239
name: regulation of nucleobase-containing compound transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0015931 ! nucleobase-containing compound transport
relationship: regulates GO:0015931 ! nucleobase-containing compound transport

[Term]
id: GO:0032240
name: negative regulation of nucleobase-containing compound transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "down regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT []
synonym: "down-regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT []
synonym: "downregulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT []
synonym: "inhibition of nucleobase, nucleoside, nucleotide and nucleic acid transport" NARROW []
synonym: "negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" RELATED [GOC:dph, GOC:tb]
is_a: GO:0032239 ! regulation of nucleobase-containing compound transport
is_a: GO:0051051 ! negative regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0015931 ! nucleobase-containing compound transport
relationship: negatively_regulates GO:0015931 ! nucleobase-containing compound transport

[Term]
id: GO:0032241
name: positive regulation of nucleobase-containing compound transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "activation of nucleobase, nucleoside, nucleotide and nucleic acid transport" NARROW []
synonym: "positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" RELATED [GOC:dph, GOC:tb]
synonym: "stimulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" NARROW []
synonym: "up regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT []
synonym: "up-regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT []
synonym: "upregulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT []
is_a: GO:0032239 ! regulation of nucleobase-containing compound transport
is_a: GO:0051050 ! positive regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0015931 ! nucleobase-containing compound transport
relationship: positively_regulates GO:0015931 ! nucleobase-containing compound transport

[Term]
id: GO:0032242
name: regulation of nucleoside transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
is_a: GO:0032239 ! regulation of nucleobase-containing compound transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0015858 ! nucleoside transport
relationship: regulates GO:0015858 ! nucleoside transport

[Term]
id: GO:0032243
name: negative regulation of nucleoside transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "down regulation of nucleoside transport" EXACT []
synonym: "down-regulation of nucleoside transport" EXACT []
synonym: "downregulation of nucleoside transport" EXACT []
synonym: "inhibition of nucleoside transport" NARROW []
is_a: GO:0032240 ! negative regulation of nucleobase-containing compound transport
is_a: GO:0032242 ! regulation of nucleoside transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0015858 ! nucleoside transport
relationship: negatively_regulates GO:0015858 ! nucleoside transport

[Term]
id: GO:0032244
name: positive regulation of nucleoside transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "activation of nucleoside transport" NARROW []
synonym: "stimulation of nucleoside transport" NARROW []
synonym: "up regulation of nucleoside transport" EXACT []
synonym: "up-regulation of nucleoside transport" EXACT []
synonym: "upregulation of nucleoside transport" EXACT []
is_a: GO:0032241 ! positive regulation of nucleobase-containing compound transport
is_a: GO:0032242 ! regulation of nucleoside transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0015858 ! nucleoside transport
relationship: positively_regulates GO:0015858 ! nucleoside transport

[Term]
id: GO:0032245
name: regulation of purine nucleoside transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a purine nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
is_a: GO:0032242 ! regulation of nucleoside transport

[Term]
id: GO:0032246
name: regulation of pyrimidine nucleoside transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a pyrimidine nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
is_a: GO:0032242 ! regulation of nucleoside transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0015864 ! pyrimidine nucleoside transport
relationship: regulates GO:0015864 ! pyrimidine nucleoside transport

[Term]
id: GO:0032247
name: negative regulation of purine nucleoside transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a purine nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "down regulation of purine nucleoside transport" EXACT []
synonym: "down-regulation of purine nucleoside transport" EXACT []
synonym: "downregulation of purine nucleoside transport" EXACT []
synonym: "inhibition of purine nucleoside transport" NARROW []
is_a: GO:0032243 ! negative regulation of nucleoside transport
is_a: GO:0032245 ! regulation of purine nucleoside transport

[Term]
id: GO:0032248
name: positive regulation of purine nucleoside transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a purine nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "activation of purine nucleoside transport" NARROW []
synonym: "stimulation of purine nucleoside transport" NARROW []
synonym: "up regulation of purine nucleoside transport" EXACT []
synonym: "up-regulation of purine nucleoside transport" EXACT []
synonym: "upregulation of purine nucleoside transport" EXACT []
is_a: GO:0032244 ! positive regulation of nucleoside transport
is_a: GO:0032245 ! regulation of purine nucleoside transport

[Term]
id: GO:0032249
name: regulation of adenosine transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of adenosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
is_a: GO:0032245 ! regulation of purine nucleoside transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032238 ! adenosine transport
relationship: regulates GO:0032238 ! adenosine transport

[Term]
id: GO:0032250
name: negative regulation of adenosine transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of adenosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "down regulation of adenosine transport" EXACT []
synonym: "down-regulation of adenosine transport" EXACT []
synonym: "downregulation of adenosine transport" EXACT []
synonym: "inhibition of adenosine transport" NARROW []
is_a: GO:0032247 ! negative regulation of purine nucleoside transport
is_a: GO:0032249 ! regulation of adenosine transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032238 ! adenosine transport
relationship: negatively_regulates GO:0032238 ! adenosine transport

[Term]
id: GO:0032251
name: positive regulation of adenosine transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of adenosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "activation of adenosine transport" NARROW []
synonym: "stimulation of adenosine transport" NARROW []
synonym: "up regulation of adenosine transport" EXACT []
synonym: "up-regulation of adenosine transport" EXACT []
synonym: "upregulation of adenosine transport" EXACT []
is_a: GO:0032248 ! positive regulation of purine nucleoside transport
is_a: GO:0032249 ! regulation of adenosine transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032238 ! adenosine transport
relationship: positively_regulates GO:0032238 ! adenosine transport

[Term]
id: GO:0032252
name: secretory granule localization
namespace: biological_process
def: "Any process in which a secretory granule is transported to, and/or maintained in, a specific location within the cell." [GOC:mah]
synonym: "secretory granule clustering" RELATED []
synonym: "secretory granule localisation" EXACT [GOC:mah]
is_a: GO:0051648 ! vesicle localization

[Term]
id: GO:0032253
name: dense core granule localization
namespace: biological_process
def: "Any process in which a dense core granule is transported to, and/or maintained in, a specific location within the cell." [GOC:mah]
synonym: "dense core granule clustering" RELATED []
synonym: "dense core granule localisation" EXACT [GOC:mah]
synonym: "dense core vesicle localization" EXACT [GOC:kmv]
is_a: GO:0032252 ! secretory granule localization

[Term]
id: GO:0032254
name: establishment of secretory granule localization
namespace: biological_process
def: "The directed movement of a secretory granule to a specific location." [GOC:mah]
synonym: "establishment of secretory granule localisation" EXACT [GOC:mah]
is_a: GO:0051650 ! establishment of vesicle localization
relationship: part_of GO:0032252 ! secretory granule localization

[Term]
id: GO:0032255
name: maintenance of secretory granule location
namespace: biological_process
def: "Any process in which a secretory granule is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:dph, GOC:mah, GOC:tb]
synonym: "maintenance of secretory granule localization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051655 ! maintenance of vesicle location
relationship: part_of GO:0032252 ! secretory granule localization

[Term]
id: GO:0032256
name: establishment of dense core granule localization
namespace: biological_process
def: "The directed movement of a dense core granule to a specific location." [GOC:mah]
synonym: "establishment of dense core granule localisation" EXACT [GOC:mah]
synonym: "establishment of dense core vesicle localization" EXACT [GOC:kmv]
is_a: GO:0032254 ! establishment of secretory granule localization
relationship: part_of GO:0032253 ! dense core granule localization

[Term]
id: GO:0032257
name: maintenance of dense core granule location
namespace: biological_process
def: "Any process in which a dense core granule is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:dph, GOC:mah, GOC:tb]
synonym: "maintenance of dense core granule localization" RELATED [GOC:dph, GOC:tb]
synonym: "maintenance of dense core vesicle location" EXACT [GOC:kmv]
is_a: GO:0032255 ! maintenance of secretory granule location
relationship: part_of GO:0032253 ! dense core granule localization

[Term]
id: GO:0032258
name: CVT pathway
namespace: biological_process
def: "A constitutive biosynthetic process that occurs under nutrient-rich conditions, in which two resident vacuolar hydrolases, aminopeptidase I and alpha-mannosidase, are sequestered into vesicles; these vesicles are transported to, and then fuse with, the vacuole. This pathway is mostly observed in yeast." [PMID:12865942, PMID:15659643]
synonym: "cytoplasm to vacuole targeting" EXACT []
synonym: "cytoplasm-to-vacuole targeting" EXACT []
is_a: GO:0006623 ! protein targeting to vacuole
relationship: has_part GO:0006624 ! vacuolar protein processing

[Term]
id: GO:0032259
name: methylation
namespace: biological_process
def: "The process in which a methyl group is covalently attached to a molecule." [GOC:mah]
subset: goslim_chembl
xref: Reactome:REACT_100463 "Methylation, Rattus norvegicus"
xref: Reactome:REACT_104378 "Methylation, Staphylococcus aureus N315"
xref: Reactome:REACT_106986 "Methylation, Schizosaccharomyces pombe"
xref: Reactome:REACT_107353 "Methylation, Taeniopygia guttata"
xref: Reactome:REACT_107808 "Methylation, Caenorhabditis elegans"
xref: Reactome:REACT_110691 "Methylation, Gallus gallus"
xref: Reactome:REACT_34638 "Methylation, Mus musculus"
xref: Reactome:REACT_6946 "Methylation, Homo sapiens"
xref: Reactome:REACT_77304 "Methylation, Oryza sativa"
xref: Reactome:REACT_78116 "Methylation, Xenopus tropicalis"
xref: Reactome:REACT_87183 "Methylation, Drosophila melanogaster"
xref: Reactome:REACT_88148 "Methylation, Canis familiaris"
xref: Reactome:REACT_90436 "Methylation, Danio rerio"
xref: Reactome:REACT_92149 "Methylation, Sus scrofa"
xref: Reactome:REACT_92596 "Methylation, Escherichia coli"
xref: Reactome:REACT_93357 "Methylation, Mycobacterium tuberculosis"
xref: Reactome:REACT_95391 "Methylation, Saccharomyces cerevisiae"
xref: Reactome:REACT_98332 "Methylation, Arabidopsis thaliana"
xref: Reactome:REACT_99471 "Methylation, Bos taurus"
xref: Reactome:REACT_99529 "Methylation, Dictyostelium discoideum"
xref: Wikipedia:Methylation
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0032260
name: response to jasmonic acid stimulus involved in jasmonic acid and ethylene-dependent systemic resistance
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus received in the context of the jasmonic acid- and ethylene (ethene)-dependent process that confers broad spectrum systemic resistance to disease in response to wounding or a pathogen." [GOC:mah]
synonym: "response to jasmonic acid stimulus during jasmonic acid and ethylene-dependent systemic resistance" RELATED [GOC:dph, GOC:tb]
is_a: GO:0009753 ! response to jasmonic acid
intersection_of: GO:0009753 ! response to jasmonic acid
intersection_of: part_of GO:0009861 ! jasmonic acid and ethylene-dependent systemic resistance
relationship: part_of GO:0009861 ! jasmonic acid and ethylene-dependent systemic resistance

[Term]
id: GO:0032261
name: purine nucleotide salvage
namespace: biological_process
def: "Any process which produces a purine nucleotide from derivatives of it, without de novo synthesis." [GOC:jp]
is_a: GO:0006164 ! purine nucleotide biosynthetic process
is_a: GO:0043101 ! purine-containing compound salvage
is_a: GO:0043173 ! nucleotide salvage

[Term]
id: GO:0032262
name: pyrimidine nucleotide salvage
namespace: biological_process
def: "Any process which produces a pyrimidine nucleotide from derivatives of it, without de novo synthesis." [GOC:mah]
is_a: GO:0006221 ! pyrimidine nucleotide biosynthetic process
is_a: GO:0008655 ! pyrimidine-containing compound salvage
is_a: GO:0043173 ! nucleotide salvage

[Term]
id: GO:0032263
name: GMP salvage
namespace: biological_process
def: "Any process which produces guanosine monophosphate from derivatives of it, without de novo synthesis." [GOC:mah]
is_a: GO:0006166 ! purine ribonucleoside salvage
is_a: GO:0006177 ! GMP biosynthetic process
is_a: GO:0032261 ! purine nucleotide salvage

[Term]
id: GO:0032264
name: IMP salvage
namespace: biological_process
def: "Any process which produces inosine monophosphate from derivatives of it, without de novo synthesis." [GOC:mah]
is_a: GO:0006188 ! IMP biosynthetic process
is_a: GO:0032261 ! purine nucleotide salvage

[Term]
id: GO:0032265
name: XMP salvage
namespace: biological_process
def: "Any process which produces xanthosine monophosphate from derivatives of it, without de novo synthesis." [GOC:mah]
is_a: GO:0032261 ! purine nucleotide salvage
is_a: GO:0097293 ! XMP biosynthetic process

[Term]
id: GO:0032266
name: phosphatidylinositol-3-phosphate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position." [GOC:bf, PMID:10209156, PMID:11395417, PMID:11557775]
synonym: "phosphatidylinositol 3-phosphate binding" EXACT []
synonym: "PtdIns-3-P binding" EXACT []
is_a: GO:1901981 ! phosphatidylinositol phosphate binding

[Term]
id: GO:0032267
name: tRNA(Ile)-lysidine synthase activity
namespace: molecular_function
def: "Catalysis of the ligation of lysine onto the cytidine residue present at the wobble position (usually position 34) of an AUA-specific isoleucine tRNA, to form the derivative lysidine. This modification converts both the codon specificity of tRNA(Ile) from AUG to AUA and its amino acid specificity from methionine to isoleucine." [PMID:14527414]
synonym: "tRNA(Ile)-2-lysyl-cytidine synthase activity" EXACT []
synonym: "tRNA(Ile)-lysidine synthetase activity" EXACT []
xref: EC:6.3.4.-
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0032268
name: regulation of cellular protein metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of cellular protein metabolism" EXACT []
is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:0051246 ! regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044267 ! cellular protein metabolic process
relationship: regulates GO:0044267 ! cellular protein metabolic process

[Term]
id: GO:0032269
name: negative regulation of cellular protein metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell." [GOC:mah]
synonym: "down regulation of cellular protein metabolic process" EXACT []
synonym: "down-regulation of cellular protein metabolic process" EXACT []
synonym: "downregulation of cellular protein metabolic process" EXACT []
synonym: "inhibition of cellular protein metabolic process" NARROW []
synonym: "negative regulation of cellular protein metabolism" EXACT []
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0032268 ! regulation of cellular protein metabolic process
is_a: GO:0051248 ! negative regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044267 ! cellular protein metabolic process
relationship: negatively_regulates GO:0044267 ! cellular protein metabolic process

[Term]
id: GO:0032270
name: positive regulation of cellular protein metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell." [GOC:mah]
synonym: "activation of cellular protein metabolic process" NARROW []
synonym: "positive regulation of cellular protein metabolism" EXACT []
synonym: "stimulation of cellular protein metabolic process" NARROW []
synonym: "up regulation of cellular protein metabolic process" EXACT []
synonym: "up-regulation of cellular protein metabolic process" EXACT []
synonym: "upregulation of cellular protein metabolic process" EXACT []
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0032268 ! regulation of cellular protein metabolic process
is_a: GO:0051247 ! positive regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044267 ! cellular protein metabolic process
relationship: positively_regulates GO:0044267 ! cellular protein metabolic process

[Term]
id: GO:0032271
name: regulation of protein polymerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the process of creating protein polymers." [GOC:mah]
synonym: "regulation of protein polymerisation" EXACT []
is_a: GO:0043254 ! regulation of protein complex assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051258 ! protein polymerization
relationship: regulates GO:0051258 ! protein polymerization

[Term]
id: GO:0032272
name: negative regulation of protein polymerization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the process of creating protein polymers." [GOC:mah]
synonym: "down regulation of protein polymerization" EXACT []
synonym: "down-regulation of protein polymerization" EXACT []
synonym: "downregulation of protein polymerization" EXACT []
synonym: "inhibition of protein polymerization" NARROW []
is_a: GO:0031333 ! negative regulation of protein complex assembly
is_a: GO:0032271 ! regulation of protein polymerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051258 ! protein polymerization
relationship: negatively_regulates GO:0051258 ! protein polymerization

[Term]
id: GO:0032273
name: positive regulation of protein polymerization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers." [GOC:mah]
synonym: "activation of protein polymerization" NARROW []
synonym: "stimulation of protein polymerization" NARROW []
synonym: "up regulation of protein polymerization" EXACT []
synonym: "up-regulation of protein polymerization" EXACT []
synonym: "upregulation of protein polymerization" EXACT []
is_a: GO:0031334 ! positive regulation of protein complex assembly
is_a: GO:0032271 ! regulation of protein polymerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051258 ! protein polymerization
relationship: positively_regulates GO:0051258 ! protein polymerization

[Term]
id: GO:0032274
name: gonadotropin secretion
namespace: biological_process
def: "The regulated release of a gonadotropin, any hormone that stimulates the gonads, especially follicle-stimulating hormone and luteinizing hormone." [GOC:mah, ISBN:0721662544]
synonym: "gonadotrophin secretion" EXACT []
is_a: GO:0060986 ! endocrine hormone secretion

[Term]
id: GO:0032275
name: luteinizing hormone secretion
namespace: biological_process
def: "The regulated release of luteinizing hormone, a gonadotropic glycoprotein hormone secreted by the anterior pituitary." [ISBN:0198506732]
is_a: GO:0032274 ! gonadotropin secretion

[Term]
id: GO:0032276
name: regulation of gonadotropin secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of a gonadotropin." [GOC:mah]
synonym: "regulation of gonadotrophin secretion" EXACT []
is_a: GO:0044060 ! regulation of endocrine process
is_a: GO:0046883 ! regulation of hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032274 ! gonadotropin secretion
relationship: regulates GO:0032274 ! gonadotropin secretion

[Term]
id: GO:0032277
name: negative regulation of gonadotropin secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a gonadotropin." [GOC:mah]
synonym: "down regulation of gonadotropin secretion" EXACT []
synonym: "down-regulation of gonadotropin secretion" EXACT []
synonym: "downregulation of gonadotropin secretion" EXACT []
synonym: "inhibition of gonadotropin secretion" NARROW []
synonym: "negative regulation of gonadotrophin secretion" EXACT [GOC:dph]
is_a: GO:0032276 ! regulation of gonadotropin secretion
is_a: GO:0046888 ! negative regulation of hormone secretion
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032274 ! gonadotropin secretion
relationship: negatively_regulates GO:0032274 ! gonadotropin secretion

[Term]
id: GO:0032278
name: positive regulation of gonadotropin secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a gonadotropin." [GOC:mah]
synonym: "activation of gonadotropin secretion" NARROW []
synonym: "positive regulation of gonadotrophin secretion" EXACT [GOC:dph]
synonym: "stimulation of gonadotropin secretion" NARROW []
synonym: "up regulation of gonadotropin secretion" EXACT []
synonym: "up-regulation of gonadotropin secretion" EXACT []
synonym: "upregulation of gonadotropin secretion" EXACT []
is_a: GO:0032276 ! regulation of gonadotropin secretion
is_a: GO:0046887 ! positive regulation of hormone secretion
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032274 ! gonadotropin secretion
relationship: positively_regulates GO:0032274 ! gonadotropin secretion

[Term]
id: GO:0032279
name: asymmetric synapse
namespace: cellular_component
def: "A type of synapse occurring between an axon and a dendritic spine or dendritic shaft. Asymmetric synapses, the most abundant synapse type in the central nervous system, involve axons that contain predominantly spherical vesicles and contain a thickened postsynaptic density." [GOC:dgh, GOC:ef]
is_a: GO:0045202 ! synapse

[Term]
id: GO:0032280
name: symmetric synapse
namespace: cellular_component
def: "A type of synapse occurring primarily on dendrite shafts and neuronal cell bodies. Symmetric synapses involve axons containing clusters of predominantly flattened or elongated vesicles and do not contain a prominent postsynaptic density." [GOC:dgh, GOC:ef]
is_a: GO:0045202 ! synapse

[Term]
id: GO:0032281
name: AMPA glutamate receptor complex
namespace: cellular_component
def: "An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. The AMPA receptors mediate fast synaptic transmission in the CNS and are composed of subunits GluR1-4, products from separate genes. These subunits have an extracellular N-terminus and an intracellular C-terminus." [GOC:ef]
synonym: "alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex" EXACT []
synonym: "AMPA receptor" RELATED []
synonym: "AMPA-selective glutamate receptor complex" EXACT []
is_a: GO:0008328 ! ionotropic glutamate receptor complex

[Term]
id: GO:0032282
name: plastid acetyl-CoA carboxylase complex
namespace: cellular_component
def: "An acetyl-CoA carboxylase complex located in the stroma of a plastid." [GOC:mah]
synonym: "plastid ACCase complex" EXACT []
is_a: GO:0009317 ! acetyl-CoA carboxylase complex
is_a: GO:0044435 ! plastid part
intersection_of: GO:0009317 ! acetyl-CoA carboxylase complex
intersection_of: part_of GO:0009536 ! plastid
relationship: part_of GO:0009532 ! plastid stroma
relationship: part_of GO:0009536 ! plastid

[Term]
id: GO:0032283
name: plastid acetate CoA-transferase complex
namespace: cellular_component
def: "An acetate CoA-transferase complex located in the stroma of a plastid." [GOC:mah]
is_a: GO:0009329 ! acetate CoA-transferase complex
is_a: GO:0044435 ! plastid part
intersection_of: GO:0009329 ! acetate CoA-transferase complex
intersection_of: part_of GO:0009536 ! plastid
relationship: part_of GO:0009536 ! plastid
relationship: part_of GO:0032282 ! plastid acetyl-CoA carboxylase complex

[Term]
id: GO:0032284
name: plastid biotin carboxylase complex
namespace: cellular_component
def: "A biotin carboxylase complex located in the stroma of a plastid." [GOC:mah]
is_a: GO:0009343 ! biotin carboxylase complex
is_a: GO:0044435 ! plastid part
intersection_of: GO:0009343 ! biotin carboxylase complex
intersection_of: part_of GO:0009536 ! plastid
relationship: part_of GO:0009536 ! plastid
relationship: part_of GO:0032282 ! plastid acetyl-CoA carboxylase complex

[Term]
id: GO:0032285
name: non-myelinated axon ensheathment
namespace: biological_process
def: "The process in which a non-myelinating glial cell membrane closes around an axon." [GOC:dgh]
synonym: "ensheathment of non-myelinated axons" EXACT [GOC:curators]
is_a: GO:0008366 ! axon ensheathment

[Term]
id: GO:0032286
name: central nervous system myelin maintenance
namespace: biological_process
def: "The process in which the structure and material content of mature central nervous system myelin is kept in a functional state." [GOC:dgh]
synonym: "myelin maintenance in central nervous system" EXACT [GOC:curators]
is_a: GO:0043217 ! myelin maintenance
relationship: part_of GO:0022010 ! central nervous system myelination

[Term]
id: GO:0032287
name: peripheral nervous system myelin maintenance
namespace: biological_process
def: "The process in which the structure and material content of mature peripheral nervous system myelin is kept in a functional state." [GOC:dgh]
synonym: "myelin maintenance in peripheral nervous system" EXACT [GOC:curators]
is_a: GO:0043217 ! myelin maintenance
relationship: part_of GO:0022011 ! myelination in peripheral nervous system

[Term]
id: GO:0032288
name: myelin assembly
namespace: biological_process
def: "The process in which the wraps of cell membrane that constitute myelin are laid down around an axon in the central or peripheral nervous system." [GOC:dgh, GOC:dph, GOC:tb]
synonym: "myelin formation" RELATED [GOC:dph, GOC:tb]
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
relationship: part_of GO:0042552 ! myelination

[Term]
id: GO:0032289
name: central nervous system myelin formation
namespace: biological_process
def: "The process in which the wraps of cell membrane that constitute myelin are laid down around an axon by an oligodendrocyte in the central nervous system." [GOC:dgh]
synonym: "myelin formation in central nervous system" EXACT [GOC:curators]
is_a: GO:0032288 ! myelin assembly
relationship: part_of GO:0022010 ! central nervous system myelination

[Term]
id: GO:0032290
name: peripheral nervous system myelin formation
namespace: biological_process
def: "The process in which the wraps of cell membrane that constitute myelin are laid down around an axon by an oligodendrocyte in the peripheral nervous system." [GOC:dgh]
synonym: "myelin formation in peripheral nervous system" EXACT [GOC:curators]
is_a: GO:0032288 ! myelin assembly
relationship: part_of GO:0022011 ! myelination in peripheral nervous system

[Term]
id: GO:0032291
name: axon ensheathment in central nervous system
namespace: biological_process
def: "The process in which a glial cell membrane closes around an axon in the central nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction." [GOC:dgh]
synonym: "ensheathment of axons in central nervous system" EXACT [GOC:curators]
is_a: GO:0008366 ! axon ensheathment

[Term]
id: GO:0032292
name: peripheral nervous system axon ensheathment
namespace: biological_process
def: "The process in which a Schwann cell membrane closes around an axon in the peripheral nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction." [GOC:dgh]
synonym: "ensheathment of axons in peripheral nervous system" EXACT [GOC:curators]
is_a: GO:0008366 ! axon ensheathment

[Term]
id: GO:0032293
name: non-myelinated axon ensheathment in central nervous system
namespace: biological_process
def: "The process in which a non-myelinating glial cell membrane encircles an axon in the central nervous system." [GOC:dgh]
synonym: "ensheathment of non-myelinated axons in central nervous system" EXACT [GOC:curators]
is_a: GO:0032285 ! non-myelinated axon ensheathment
is_a: GO:0032291 ! axon ensheathment in central nervous system

[Term]
id: GO:0032294
name: peripheral nervous system non-myelinated axon ensheathment
namespace: biological_process
def: "The process in which a non-myelinating Schwann cell membrane encircles an axon in the peripheral nervous system. A single non-myelinating Schwann cell will typically associate with multiple axons." [GOC:dgh]
synonym: "ensheathment of non-myelinated axons in peripheral nervous system" EXACT [GOC:curators]
is_a: GO:0032285 ! non-myelinated axon ensheathment
is_a: GO:0032292 ! peripheral nervous system axon ensheathment

[Term]
id: GO:0032295
name: ensheathment of neuronal cell bodies
namespace: biological_process
def: "The process in which satellite glial cells isolate neuronal cell bodies." [GOC:dgh]
is_a: GO:0007272 ! ensheathment of neurons

[Term]
id: GO:0032296
name: double-stranded RNA-specific ribonuclease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of phosphodiester bonds in double-stranded RNA molecules." [GOC:mah]
synonym: "double-stranded RNA-specific RNase activity" EXACT []
synonym: "dsRNA-specific ribonuclease activity" EXACT []
synonym: "dsRNA-specific RNase activity" EXACT []
is_a: GO:0004540 ! ribonuclease activity

[Term]
id: GO:0032297
name: negative regulation of DNA-dependent DNA replication initiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of initiation of DNA-dependent DNA replication." [GOC:mah]
synonym: "down regulation of DNA replication initiation" EXACT []
synonym: "down-regulation of DNA replication initiation" EXACT []
synonym: "downregulation of DNA replication initiation" EXACT []
synonym: "inhibition of DNA replication initiation" NARROW []
synonym: "negative regulation of DNA replication initiation" BROAD [GOC:vw]
is_a: GO:0030174 ! regulation of DNA-dependent DNA replication initiation
is_a: GO:2000104 ! negative regulation of DNA-dependent DNA replication
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006270 ! DNA replication initiation
relationship: negatively_regulates GO:0006270 ! DNA replication initiation

[Term]
id: GO:0032298
name: positive regulation of DNA-dependent DNA replication initiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of initiation of DNA-dependent DNA replication." [GOC:mah]
synonym: "activation of DNA replication initiation" NARROW []
synonym: "negative regulation of DNA replication initiation" BROAD [GOC:vw]
synonym: "stimulation of DNA replication initiation" NARROW []
synonym: "up regulation of DNA replication initiation" EXACT []
synonym: "up-regulation of DNA replication initiation" EXACT []
synonym: "upregulation of DNA replication initiation" EXACT []
is_a: GO:0030174 ! regulation of DNA-dependent DNA replication initiation
is_a: GO:2000105 ! positive regulation of DNA-dependent DNA replication
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006270 ! DNA replication initiation
relationship: positively_regulates GO:0006270 ! DNA replication initiation

[Term]
id: GO:0032299
name: ribonuclease H2 complex
namespace: cellular_component
def: "A protein complex that possesses ribonuclease H activity, in which the catalytic subunit is a member of the RNase H2 (or HII) class. For example, in Saccharomyces the complex contains Rnh201p, Rnh202p and Rnh203p." [GOC:mah, PMID:14734815]
synonym: "RNase H2 complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0032300
name: mismatch repair complex
namespace: cellular_component
def: "Any complex formed of proteins that act in mismatch repair." [GOC:mah]
subset: goslim_pir
is_a: GO:0044424 ! intracellular part
is_a: GO:1990391 ! DNA repair complex

[Term]
id: GO:0032301
name: MutSalpha complex
namespace: cellular_component
def: "A heterodimer involved in the recognition and repair of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MSH2 and MSH6." [PMID:11005803]
synonym: "MMR complex" BROAD []
synonym: "MSH2/MSH6 complex" EXACT []
is_a: GO:0032300 ! mismatch repair complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0032302
name: MutSbeta complex
namespace: cellular_component
def: "A heterodimer involved in binding to and correcting insertion/deletion mutations. In human the complex consists of two subunits, MSH2 and MSH3." [PMID:11005803]
synonym: "MMR complex" BROAD []
synonym: "MSH2/MSH3 complex" EXACT []
is_a: GO:0032300 ! mismatch repair complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0032303
name: regulation of icosanoid secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the controlled release of an icosanoid from a cell." [GOC:mah]
synonym: "regulation of eicosanoid secretion" EXACT []
is_a: GO:0051046 ! regulation of secretion
is_a: GO:2000191 ! regulation of fatty acid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032309 ! icosanoid secretion
relationship: regulates GO:0032309 ! icosanoid secretion

[Term]
id: GO:0032304
name: negative regulation of icosanoid secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of an icosanoid from a cell." [GOC:mah]
synonym: "down regulation of icosanoid secretion" EXACT []
synonym: "down-regulation of icosanoid secretion" EXACT []
synonym: "downregulation of icosanoid secretion" EXACT []
synonym: "inhibition of icosanoid secretion" NARROW []
synonym: "negative regulation of eicosanoid secretion" EXACT []
is_a: GO:0032303 ! regulation of icosanoid secretion
is_a: GO:0051048 ! negative regulation of secretion
is_a: GO:2000192 ! negative regulation of fatty acid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032309 ! icosanoid secretion
relationship: negatively_regulates GO:0032309 ! icosanoid secretion

[Term]
id: GO:0032305
name: positive regulation of icosanoid secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the controlled release of an icosanoid from a cell." [GOC:mah]
synonym: "activation of icosanoid secretion" NARROW []
synonym: "positive regulation of eicosanoid secretion" EXACT []
synonym: "stimulation of icosanoid secretion" NARROW []
synonym: "up regulation of icosanoid secretion" EXACT []
synonym: "up-regulation of icosanoid secretion" EXACT []
synonym: "upregulation of icosanoid secretion" EXACT []
is_a: GO:0032303 ! regulation of icosanoid secretion
is_a: GO:0051047 ! positive regulation of secretion
is_a: GO:2000193 ! positive regulation of fatty acid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032309 ! icosanoid secretion
relationship: positively_regulates GO:0032309 ! icosanoid secretion

[Term]
id: GO:0032306
name: regulation of prostaglandin secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of a prostaglandin from a cell." [GOC:mah]
synonym: "regulation of prostacyclin secretion" NARROW []
is_a: GO:0032303 ! regulation of icosanoid secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032310 ! prostaglandin secretion
relationship: regulates GO:0032310 ! prostaglandin secretion

[Term]
id: GO:0032307
name: negative regulation of prostaglandin secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a prostaglandin from a cell." [GOC:mah]
synonym: "down regulation of prostaglandin secretion" EXACT []
synonym: "down-regulation of prostaglandin secretion" EXACT []
synonym: "downregulation of prostaglandin secretion" EXACT []
synonym: "inhibition of prostaglandin secretion" NARROW []
synonym: "negative regulation of prostacyclin secretion" NARROW []
is_a: GO:0032304 ! negative regulation of icosanoid secretion
is_a: GO:0032306 ! regulation of prostaglandin secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032310 ! prostaglandin secretion
relationship: negatively_regulates GO:0032310 ! prostaglandin secretion

[Term]
id: GO:0032308
name: positive regulation of prostaglandin secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a prostaglandin from a cell." [GOC:mah]
synonym: "activation of prostaglandin secretion" NARROW []
synonym: "positive regulation of prostacyclin secretion" NARROW []
synonym: "stimulation of prostaglandin secretion" NARROW []
synonym: "up regulation of prostaglandin secretion" EXACT []
synonym: "up-regulation of prostaglandin secretion" EXACT []
synonym: "upregulation of prostaglandin secretion" EXACT []
is_a: GO:0032305 ! positive regulation of icosanoid secretion
is_a: GO:0032306 ! regulation of prostaglandin secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032310 ! prostaglandin secretion
relationship: positively_regulates GO:0032310 ! prostaglandin secretion

[Term]
id: GO:0032309
name: icosanoid secretion
namespace: biological_process
def: "The controlled release of icosanoids, any of a group of C20 polyunsaturated fatty acids from a cell or a tissue." [GOC:mah]
synonym: "eicosanoid secretion" EXACT []
is_a: GO:0046717 ! acid secretion
is_a: GO:0071715 ! icosanoid transport

[Term]
id: GO:0032310
name: prostaglandin secretion
namespace: biological_process
def: "The regulated release of a prostaglandin, any of a group of biologically active metabolites which contain a cyclopentane ring, from a cell or a tissue." [GOC:mah]
synonym: "prostacyclin secretion" NARROW []
is_a: GO:0015732 ! prostaglandin transport
is_a: GO:0032309 ! icosanoid secretion

[Term]
id: GO:0032311
name: angiogenin-PRI complex
namespace: cellular_component
def: "A stable heterodimer of angiogenin and placental ribonuclease inhibitor; interaction between angiogenin and PRI prevents angiogenin binding to its receptor to stimulate angiogenesis." [PMID:2706246, PMID:3470787]
synonym: "angiogenin-placental ribonuclease inhibitor complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044421 ! extracellular region part

[Term]
id: GO:0032322
name: ubiquinone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah]
synonym: "ubiquinone breakdown" EXACT []
synonym: "ubiquinone catabolism" EXACT []
synonym: "ubiquinone degradation" EXACT []
is_a: GO:0006743 ! ubiquinone metabolic process
is_a: GO:1901662 ! quinone catabolic process

[Term]
id: GO:0032323
name: lipoate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lipoate." [GOC:mah]
synonym: "lipoic acid breakdown" EXACT []
synonym: "lipoic acid catabolism" EXACT []
synonym: "lipoic acid degradation" EXACT []
is_a: GO:0009062 ! fatty acid catabolic process
is_a: GO:0009106 ! lipoate metabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process

[Term]
id: GO:0032324
name: molybdopterin cofactor biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [GOC:mah]
synonym: "molybdopterin cofactor anabolism" EXACT []
synonym: "molybdopterin cofactor biosynthesis" RELATED []
synonym: "molybdopterin cofactor formation" RELATED []
synonym: "molybdopterin cofactor synthesis" EXACT []
xref: MetaCyc:Molybdenum-Cofactor-Biosynthesis
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0043545 ! molybdopterin cofactor metabolic process
is_a: GO:0051188 ! cofactor biosynthetic process
is_a: GO:0090407 ! organophosphate biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process
relationship: has_part GO:0030366 ! molybdopterin synthase activity
relationship: has_part GO:0031071 ! cysteine desulfurase activity
relationship: has_part GO:0061597 ! cyclic pyranopterin monophosphate synthase activity
relationship: has_part GO:0061598 ! molybdopterin adenylyltransferase activity
relationship: has_part GO:0061604 ! molybdopterin-synthase sulfurtransferase activity
relationship: has_part GO:0061605 ! molybdopterin-synthase adenylyltransferase activity

[Term]
id: GO:0032325
name: molybdopterin cofactor catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [GOC:mah]
is_a: GO:0043545 ! molybdopterin cofactor metabolic process
is_a: GO:0046434 ! organophosphate catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:0051187 ! cofactor catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process

[Term]
id: GO:0032326
name: Mo-molybdopterin cofactor catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands." [GOC:mah]
subset: gosubset_prok
synonym: "Mo-molybdopterin cofactor breakdown" EXACT []
synonym: "Mo-molybdopterin cofactor catabolism" EXACT []
synonym: "Mo-molybdopterin cofactor degradation" EXACT []
synonym: "Moco catabolic process" BROAD []
synonym: "Moco catabolism" BROAD []
is_a: GO:0019720 ! Mo-molybdopterin cofactor metabolic process
is_a: GO:0032325 ! molybdopterin cofactor catabolic process

[Term]
id: GO:0032327
name: W-molybdopterin cofactor catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the W-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear tungsten ion (W) coordinated by one or two molybdopterin ligands." [GOC:mah]
subset: gosubset_prok
synonym: "Moco catabolic process" BROAD []
synonym: "Moco catabolism" BROAD []
synonym: "W-molybdopterin cofactor breakdown" EXACT []
synonym: "W-molybdopterin cofactor catabolism" EXACT []
synonym: "W-molybdopterin cofactor degradation" EXACT []
is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0032325 ! molybdopterin cofactor catabolic process
is_a: GO:0042046 ! W-molybdopterin cofactor metabolic process

[Term]
id: GO:0032328
name: alanine transport
namespace: biological_process
def: "The directed movement of alanine, 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
is_a: GO:0006812 ! cation transport
is_a: GO:0015804 ! neutral amino acid transport

[Term]
id: GO:0032329
name: serine transport
namespace: biological_process
def: "The directed movement of L-serine, 2-amino-3-hydroxypropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
is_a: GO:0006812 ! cation transport
is_a: GO:0015804 ! neutral amino acid transport

[Term]
id: GO:0032330
name: regulation of chondrocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chondrocyte differentiation." [GOC:mah]
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:0061035 ! regulation of cartilage development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002062 ! chondrocyte differentiation
relationship: regulates GO:0002062 ! chondrocyte differentiation

[Term]
id: GO:0032331
name: negative regulation of chondrocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chondrocyte differentiation." [GOC:mah]
synonym: "down regulation of chondrocyte differentiation" EXACT []
synonym: "down-regulation of chondrocyte differentiation" EXACT []
synonym: "downregulation of chondrocyte differentiation" EXACT []
synonym: "inhibition of chondrocyte differentiation" NARROW []
is_a: GO:0032330 ! regulation of chondrocyte differentiation
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0061037 ! negative regulation of cartilage development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002062 ! chondrocyte differentiation
relationship: negatively_regulates GO:0002062 ! chondrocyte differentiation

[Term]
id: GO:0032332
name: positive regulation of chondrocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chondrocyte differentiation." [GOC:mah]
synonym: "activation of chondrocyte differentiation" NARROW []
synonym: "stimulation of chondrocyte differentiation" NARROW []
synonym: "up regulation of chondrocyte differentiation" EXACT []
synonym: "up-regulation of chondrocyte differentiation" EXACT []
synonym: "upregulation of chondrocyte differentiation" EXACT []
is_a: GO:0032330 ! regulation of chondrocyte differentiation
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0061036 ! positive regulation of cartilage development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002062 ! chondrocyte differentiation
relationship: positively_regulates GO:0002062 ! chondrocyte differentiation

[Term]
id: GO:0032333
name: activin secretion
namespace: biological_process
def: "The regulated release of activin, a nonsteroidal regulator composed of two covalently linked beta subunits, which is synthesized in the pituitary gland and gonads and stimulates the secretion of follicle-stimulating hormone." [GOC:mah]
is_a: GO:0046879 ! hormone secretion

[Term]
id: GO:0032334
name: inhibin secretion
namespace: biological_process
def: "The regulated release of an inhibin, either of two glycoproteins (designated A and B), secreted by the gonads and present in seminal plasma and follicular fluid, that inhibit pituitary production of follicle-stimulating hormone." [GOC:mah]
is_a: GO:0060986 ! endocrine hormone secretion

[Term]
id: GO:0032335
name: regulation of activin secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of activin from a cell." [GOC:mah]
is_a: GO:0046883 ! regulation of hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032333 ! activin secretion
relationship: regulates GO:0032333 ! activin secretion

[Term]
id: GO:0032336
name: negative regulation of activin secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of activin from a cell." [GOC:mah]
synonym: "down regulation of activin secretion" EXACT []
synonym: "down-regulation of activin secretion" EXACT []
synonym: "downregulation of activin secretion" EXACT []
synonym: "inhibition of activin secretion" NARROW []
is_a: GO:0032335 ! regulation of activin secretion
is_a: GO:0046888 ! negative regulation of hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032333 ! activin secretion
relationship: negatively_regulates GO:0032333 ! activin secretion

[Term]
id: GO:0032337
name: positive regulation of activin secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of activin from a cell." [GOC:mah]
synonym: "activation of activin secretion" NARROW []
synonym: "stimulation of activin secretion" NARROW []
synonym: "up regulation of activin secretion" EXACT []
synonym: "up-regulation of activin secretion" EXACT []
synonym: "upregulation of activin secretion" EXACT []
is_a: GO:0032335 ! regulation of activin secretion
is_a: GO:0046887 ! positive regulation of hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032333 ! activin secretion
relationship: positively_regulates GO:0032333 ! activin secretion

[Term]
id: GO:0032338
name: regulation of inhibin secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of inhibin from a cell." [GOC:mah]
is_a: GO:0044060 ! regulation of endocrine process
is_a: GO:0046883 ! regulation of hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032334 ! inhibin secretion
relationship: regulates GO:0032334 ! inhibin secretion

[Term]
id: GO:0032339
name: negative regulation of inhibin secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of inhibin from a cell." [GOC:mah]
synonym: "down regulation of inhibin secretion" EXACT []
synonym: "down-regulation of inhibin secretion" EXACT []
synonym: "downregulation of inhibin secretion" EXACT []
synonym: "inhibition of inhibin secretion" NARROW []
is_a: GO:0032338 ! regulation of inhibin secretion
is_a: GO:0046888 ! negative regulation of hormone secretion
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032334 ! inhibin secretion
relationship: negatively_regulates GO:0032334 ! inhibin secretion

[Term]
id: GO:0032340
name: positive regulation of inhibin secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of inhibin from a cell." [GOC:mah]
synonym: "activation of inhibin secretion" NARROW []
synonym: "stimulation of inhibin secretion" NARROW []
synonym: "up regulation of inhibin secretion" EXACT []
synonym: "up-regulation of inhibin secretion" EXACT []
synonym: "upregulation of inhibin secretion" EXACT []
is_a: GO:0032338 ! regulation of inhibin secretion
is_a: GO:0046887 ! positive regulation of hormone secretion
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032334 ! inhibin secretion
relationship: positively_regulates GO:0032334 ! inhibin secretion

[Term]
id: GO:0032341
name: aldosterone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance." [PMID:16527843]
synonym: "aldosterone metabolism" EXACT []
is_a: GO:0006066 ! alcohol metabolic process
is_a: GO:0006081 ! cellular aldehyde metabolic process
is_a: GO:0008207 ! C21-steroid hormone metabolic process
is_a: GO:0008212 ! mineralocorticoid metabolic process
is_a: GO:0042180 ! cellular ketone metabolic process

[Term]
id: GO:0032342
name: aldosterone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance." [PMID:16527843]
is_a: GO:0006700 ! C21-steroid hormone biosynthetic process
is_a: GO:0006705 ! mineralocorticoid biosynthetic process
is_a: GO:0032341 ! aldosterone metabolic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0046165 ! alcohol biosynthetic process
is_a: GO:0046184 ! aldehyde biosynthetic process

[Term]
id: GO:0032343
name: aldosterone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance." [PMID:16527843]
is_a: GO:0006712 ! mineralocorticoid catabolic process
is_a: GO:0008208 ! C21-steroid hormone catabolic process
is_a: GO:0032341 ! aldosterone metabolic process
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:0046164 ! alcohol catabolic process
is_a: GO:0046185 ! aldehyde catabolic process

[Term]
id: GO:0032344
name: regulation of aldosterone metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving aldosterone." [GOC:mah]
synonym: "regulation of aldosterone metabolism" EXACT []
is_a: GO:0010565 ! regulation of cellular ketone metabolic process
is_a: GO:0019218 ! regulation of steroid metabolic process
is_a: GO:0032350 ! regulation of hormone metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032341 ! aldosterone metabolic process
relationship: regulates GO:0032341 ! aldosterone metabolic process

[Term]
id: GO:0032345
name: negative regulation of aldosterone metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving aldosterone." [GOC:mah]
synonym: "down regulation of aldosterone metabolic process" EXACT []
synonym: "down-regulation of aldosterone metabolic process" EXACT []
synonym: "downregulation of aldosterone metabolic process" EXACT []
synonym: "inhibition of aldosterone metabolic process" NARROW []
synonym: "negative regulation of aldosterone metabolism" EXACT []
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0032344 ! regulation of aldosterone metabolic process
is_a: GO:0032351 ! negative regulation of hormone metabolic process
is_a: GO:0045939 ! negative regulation of steroid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032341 ! aldosterone metabolic process
relationship: negatively_regulates GO:0032341 ! aldosterone metabolic process

[Term]
id: GO:0032346
name: positive regulation of aldosterone metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving aldosterone." [GOC:mah]
synonym: "activation of aldosterone metabolic process" NARROW []
synonym: "positive regulation of aldosterone metabolism" EXACT []
synonym: "stimulation of aldosterone metabolic process" NARROW []
synonym: "up regulation of aldosterone metabolic process" EXACT []
synonym: "up-regulation of aldosterone metabolic process" EXACT []
synonym: "upregulation of aldosterone metabolic process" EXACT []
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0032344 ! regulation of aldosterone metabolic process
is_a: GO:0032352 ! positive regulation of hormone metabolic process
is_a: GO:0045940 ! positive regulation of steroid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032341 ! aldosterone metabolic process
relationship: positively_regulates GO:0032341 ! aldosterone metabolic process

[Term]
id: GO:0032347
name: regulation of aldosterone biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone." [GOC:mah]
is_a: GO:0010566 ! regulation of ketone biosynthetic process
is_a: GO:0032344 ! regulation of aldosterone metabolic process
is_a: GO:0090030 ! regulation of steroid hormone biosynthetic process
is_a: GO:1902930 ! regulation of alcohol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032342 ! aldosterone biosynthetic process
relationship: regulates GO:0032342 ! aldosterone biosynthetic process

[Term]
id: GO:0032348
name: negative regulation of aldosterone biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone." [GOC:mah]
synonym: "down regulation of aldosterone biosynthetic process" EXACT []
synonym: "down-regulation of aldosterone biosynthetic process" EXACT []
synonym: "downregulation of aldosterone biosynthetic process" EXACT []
synonym: "inhibition of aldosterone biosynthetic process" NARROW []
is_a: GO:0032345 ! negative regulation of aldosterone metabolic process
is_a: GO:0032347 ! regulation of aldosterone biosynthetic process
is_a: GO:0090032 ! negative regulation of steroid hormone biosynthetic process
is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032342 ! aldosterone biosynthetic process
relationship: negatively_regulates GO:0032342 ! aldosterone biosynthetic process

[Term]
id: GO:0032349
name: positive regulation of aldosterone biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone." [GOC:mah]
synonym: "activation of aldosterone biosynthetic process" NARROW []
synonym: "stimulation of aldosterone biosynthetic process" NARROW []
synonym: "up regulation of aldosterone biosynthetic process" EXACT []
synonym: "up-regulation of aldosterone biosynthetic process" EXACT []
synonym: "upregulation of aldosterone biosynthetic process" EXACT []
is_a: GO:0032346 ! positive regulation of aldosterone metabolic process
is_a: GO:0032347 ! regulation of aldosterone biosynthetic process
is_a: GO:0090031 ! positive regulation of steroid hormone biosynthetic process
is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032342 ! aldosterone biosynthetic process
relationship: positively_regulates GO:0032342 ! aldosterone biosynthetic process

[Term]
id: GO:0032350
name: regulation of hormone metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving any hormone." [GOC:mah]
synonym: "regulation of hormone metabolism" EXACT []
is_a: GO:0010817 ! regulation of hormone levels
is_a: GO:0019222 ! regulation of metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042445 ! hormone metabolic process
relationship: regulates GO:0042445 ! hormone metabolic process

[Term]
id: GO:0032351
name: negative regulation of hormone metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving any hormone." [GOC:mah]
synonym: "down regulation of hormone metabolic process" EXACT []
synonym: "down-regulation of hormone metabolic process" EXACT []
synonym: "downregulation of hormone metabolic process" EXACT []
synonym: "inhibition of hormone metabolic process" NARROW []
synonym: "negative regulation of hormone metabolism" EXACT []
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0032350 ! regulation of hormone metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042445 ! hormone metabolic process
relationship: negatively_regulates GO:0042445 ! hormone metabolic process

[Term]
id: GO:0032352
name: positive regulation of hormone metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving any hormone." [GOC:mah]
synonym: "activation of hormone metabolic process" NARROW []
synonym: "positive regulation of hormone metabolism" EXACT []
synonym: "stimulation of hormone metabolic process" NARROW []
synonym: "up regulation of hormone metabolic process" EXACT []
synonym: "up-regulation of hormone metabolic process" EXACT []
synonym: "upregulation of hormone metabolic process" EXACT []
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0032350 ! regulation of hormone metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042445 ! hormone metabolic process
relationship: positively_regulates GO:0042445 ! hormone metabolic process

[Term]
id: GO:0032353
name: negative regulation of hormone biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones." [GOC:ai]
synonym: "down regulation of hormone biosynthetic process" EXACT []
synonym: "down-regulation of hormone biosynthetic process" EXACT []
synonym: "downregulation of hormone biosynthetic process" EXACT []
synonym: "inhibition of hormone biosynthetic process" NARROW []
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0032351 ! negative regulation of hormone metabolic process
is_a: GO:0046885 ! regulation of hormone biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042446 ! hormone biosynthetic process
relationship: negatively_regulates GO:0042446 ! hormone biosynthetic process

[Term]
id: GO:0032354
name: response to follicle-stimulating hormone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a follicle-stimulating hormone stimulus." [GOC:mah]
synonym: "response to follicle stimulating hormone stimulus" EXACT []
synonym: "response to follicle-stimulating hormone stimulus" EXACT [GOC:dos]
synonym: "response to FSH stimulus" EXACT []
is_a: GO:0034698 ! response to gonadotropin

[Term]
id: GO:0032355
name: response to estradiol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen." [GOC:mah, ISBN:0911910123]
synonym: "response to E2 stimulus" EXACT []
synonym: "response to estradiol stimulus" EXACT [GOC:dos]
is_a: GO:0043627 ! response to estrogen
is_a: GO:0097305 ! response to alcohol

[Term]
id: GO:0032356
name: oxidized DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with oxidized residues in DNA." [GOC:vk]
synonym: "oxidised DNA binding" EXACT []
is_a: GO:0003684 ! damaged DNA binding

[Term]
id: GO:0032357
name: oxidized purine DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with oxidized purine residues in DNA." [GOC:vk]
synonym: "oxidised purine DNA binding" EXACT []
synonym: "oxidized purine base DNA binding" EXACT [CHEBI:26386]
synonym: "oxidized purine nucleobase DNA binding" EXACT [CHEBI:26386]
is_a: GO:0032356 ! oxidized DNA binding

[Term]
id: GO:0032358
name: oxidized pyrimidine DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with oxidized pyrimidine residues in DNA." [GOC:vk]
synonym: "oxidised pyrimidine DNA binding" EXACT []
synonym: "oxidized pyrimidine base DNA binding" EXACT [CHEBI:26432]
synonym: "oxidized pyrimidine nucleobase DNA binding" EXACT [CHEBI:26432]
is_a: GO:0032356 ! oxidized DNA binding

[Term]
id: GO:0032359
name: provirus excision
namespace: biological_process
def: "The molecular events that lead to the excision of a viral genome from the host genome." [GOC:mlg]
synonym: "prophage excision" EXACT []
is_a: GO:0019046 ! release from viral latency

[Term]
id: GO:0032361
name: pyridoxal phosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6." [GOC:mah]
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042822 ! pyridoxal phosphate metabolic process
is_a: GO:0046185 ! aldehyde catabolic process
is_a: GO:0046434 ! organophosphate catabolic process
is_a: GO:0051187 ! cofactor catabolic process
is_a: GO:0072526 ! pyridine-containing compound catabolic process
is_a: GO:1901616 ! organic hydroxy compound catabolic process

[Term]
id: GO:0032362
name: obsolete FAD catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of FAD, the oxidized form of flavin-adenine dinucleotide." [CHEBI:16238, GOC:mah]
comment: The reason for making this term obsolete is that it gets misused in cases where phosphates are simply being removed from a small molecule. We found no cases where these molecules genuinely underwent catabolism.
synonym: "FAD breakdown" EXACT [GOC:mah]
synonym: "FAD catabolism" EXACT [GOC:mah]
synonym: "FAD degradation" EXACT [GOC:mah]
synonym: "oxidized flavin adenine dinucleotide catabolic process" EXACT [GOC:mah]
is_obsolete: true

[Term]
id: GO:0032363
name: FMN catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of FMN, riboflavin 5'-(dihydrogen phosphate), a coenzyme for a number of oxidative enzymes including NADH dehydrogenase." [GOC:mah]
is_a: GO:0009109 ! coenzyme catabolic process
is_a: GO:0009158 ! ribonucleoside monophosphate catabolic process
is_a: GO:0009261 ! ribonucleotide catabolic process
is_a: GO:0042728 ! flavin-containing compound catabolic process
is_a: GO:0046444 ! FMN metabolic process

[Term]
id: GO:0032364
name: oxygen homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of an internal steady state of oxygen within an organism or cell." [GOC:rph]
is_a: GO:0033483 ! gas homeostasis

[Term]
id: GO:0032365
name: intracellular lipid transport
namespace: biological_process
def: "The directed movement of lipids within cells." [GOC:mah]
is_a: GO:0006869 ! lipid transport
is_a: GO:1902582 ! single-organism intracellular transport
intersection_of: GO:0006869 ! lipid transport
intersection_of: occurs_in GO:0005622 ! intracellular
relationship: occurs_in GO:0005622 ! intracellular

[Term]
id: GO:0032366
name: intracellular sterol transport
namespace: biological_process
def: "The directed movement of sterols within cells." [GOC:mah]
is_a: GO:0015918 ! sterol transport
is_a: GO:0032365 ! intracellular lipid transport
intersection_of: GO:0015918 ! sterol transport
intersection_of: occurs_in GO:0005622 ! intracellular
relationship: occurs_in GO:0005622 ! intracellular

[Term]
id: GO:0032367
name: intracellular cholesterol transport
namespace: biological_process
def: "The directed movement of cholesterol, cholest-5-en-3-beta-ol, within cells." [GOC:mah]
is_a: GO:0030301 ! cholesterol transport
is_a: GO:0032366 ! intracellular sterol transport
intersection_of: GO:0030301 ! cholesterol transport
intersection_of: occurs_in GO:0005622 ! intracellular
relationship: occurs_in GO:0005622 ! intracellular

[Term]
id: GO:0032368
name: regulation of lipid transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006869 ! lipid transport
relationship: regulates GO:0006869 ! lipid transport

[Term]
id: GO:0032369
name: negative regulation of lipid transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "down regulation of lipid transport" EXACT []
synonym: "down-regulation of lipid transport" EXACT []
synonym: "downregulation of lipid transport" EXACT []
synonym: "inhibition of lipid transport" NARROW []
is_a: GO:0032368 ! regulation of lipid transport
is_a: GO:0051051 ! negative regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006869 ! lipid transport
relationship: negatively_regulates GO:0006869 ! lipid transport

[Term]
id: GO:0032370
name: positive regulation of lipid transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "activation of lipid transport" NARROW []
synonym: "stimulation of lipid transport" NARROW []
synonym: "up regulation of lipid transport" EXACT []
synonym: "up-regulation of lipid transport" EXACT []
synonym: "upregulation of lipid transport" EXACT []
is_a: GO:0032368 ! regulation of lipid transport
is_a: GO:0051050 ! positive regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006869 ! lipid transport
relationship: positively_regulates GO:0006869 ! lipid transport

[Term]
id: GO:0032371
name: regulation of sterol transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
is_a: GO:0032368 ! regulation of lipid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0015918 ! sterol transport
relationship: regulates GO:0015918 ! sterol transport

[Term]
id: GO:0032372
name: negative regulation of sterol transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "down regulation of sterol transport" EXACT []
synonym: "down-regulation of sterol transport" EXACT []
synonym: "downregulation of sterol transport" EXACT []
synonym: "inhibition of sterol transport" NARROW []
is_a: GO:0032369 ! negative regulation of lipid transport
is_a: GO:0032371 ! regulation of sterol transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0015918 ! sterol transport
relationship: negatively_regulates GO:0015918 ! sterol transport

[Term]
id: GO:0032373
name: positive regulation of sterol transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "activation of sterol transport" NARROW []
synonym: "stimulation of sterol transport" NARROW []
synonym: "up regulation of sterol transport" EXACT []
synonym: "up-regulation of sterol transport" EXACT []
synonym: "upregulation of sterol transport" EXACT []
is_a: GO:0032370 ! positive regulation of lipid transport
is_a: GO:0032371 ! regulation of sterol transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0015918 ! sterol transport
relationship: positively_regulates GO:0015918 ! sterol transport

[Term]
id: GO:0032374
name: regulation of cholesterol transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
is_a: GO:0032371 ! regulation of sterol transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030301 ! cholesterol transport
relationship: regulates GO:0030301 ! cholesterol transport

[Term]
id: GO:0032375
name: negative regulation of cholesterol transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "down regulation of cholesterol transport" EXACT []
synonym: "down-regulation of cholesterol transport" EXACT []
synonym: "downregulation of cholesterol transport" EXACT []
synonym: "inhibition of cholesterol transport" NARROW []
is_a: GO:0032372 ! negative regulation of sterol transport
is_a: GO:0032374 ! regulation of cholesterol transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030301 ! cholesterol transport
relationship: negatively_regulates GO:0030301 ! cholesterol transport

[Term]
id: GO:0032376
name: positive regulation of cholesterol transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "activation of cholesterol transport" NARROW []
synonym: "stimulation of cholesterol transport" NARROW []
synonym: "up regulation of cholesterol transport" EXACT []
synonym: "up-regulation of cholesterol transport" EXACT []
synonym: "upregulation of cholesterol transport" EXACT []
is_a: GO:0032373 ! positive regulation of sterol transport
is_a: GO:0032374 ! regulation of cholesterol transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030301 ! cholesterol transport
relationship: positively_regulates GO:0030301 ! cholesterol transport

[Term]
id: GO:0032377
name: regulation of intracellular lipid transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of lipids within cells." [GOC:mah]
is_a: GO:0032368 ! regulation of lipid transport
is_a: GO:0032386 ! regulation of intracellular transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032365 ! intracellular lipid transport
relationship: regulates GO:0032365 ! intracellular lipid transport

[Term]
id: GO:0032378
name: negative regulation of intracellular lipid transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids within cells." [GOC:mah]
synonym: "down regulation of intracellular lipid transport" EXACT []
synonym: "down-regulation of intracellular lipid transport" EXACT []
synonym: "downregulation of intracellular lipid transport" EXACT []
synonym: "inhibition of intracellular lipid transport" NARROW []
is_a: GO:0032369 ! negative regulation of lipid transport
is_a: GO:0032377 ! regulation of intracellular lipid transport
is_a: GO:0032387 ! negative regulation of intracellular transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032365 ! intracellular lipid transport
relationship: negatively_regulates GO:0032365 ! intracellular lipid transport

[Term]
id: GO:0032379
name: positive regulation of intracellular lipid transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of lipids within cells." [GOC:mah]
synonym: "activation of intracellular lipid transport" NARROW []
synonym: "stimulation of intracellular lipid transport" NARROW []
synonym: "up regulation of intracellular lipid transport" EXACT []
synonym: "up-regulation of intracellular lipid transport" EXACT []
synonym: "upregulation of intracellular lipid transport" EXACT []
is_a: GO:0032370 ! positive regulation of lipid transport
is_a: GO:0032377 ! regulation of intracellular lipid transport
is_a: GO:0032388 ! positive regulation of intracellular transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032365 ! intracellular lipid transport
relationship: positively_regulates GO:0032365 ! intracellular lipid transport

[Term]
id: GO:0032380
name: regulation of intracellular sterol transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of sterols within cells." [GOC:mah]
is_a: GO:0032371 ! regulation of sterol transport
is_a: GO:0032377 ! regulation of intracellular lipid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032366 ! intracellular sterol transport
relationship: regulates GO:0032366 ! intracellular sterol transport

[Term]
id: GO:0032381
name: negative regulation of intracellular sterol transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of sterols within cells." [GOC:mah]
synonym: "down regulation of intracellular sterol transport" EXACT []
synonym: "down-regulation of intracellular sterol transport" EXACT []
synonym: "downregulation of intracellular sterol transport" EXACT []
synonym: "inhibition of intracellular sterol transport" NARROW []
is_a: GO:0032372 ! negative regulation of sterol transport
is_a: GO:0032378 ! negative regulation of intracellular lipid transport
is_a: GO:0032380 ! regulation of intracellular sterol transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032366 ! intracellular sterol transport
relationship: negatively_regulates GO:0032366 ! intracellular sterol transport

[Term]
id: GO:0032382
name: positive regulation of intracellular sterol transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of sterols within cells." [GOC:mah]
synonym: "activation of intracellular sterol transport" NARROW []
synonym: "stimulation of intracellular sterol transport" NARROW []
synonym: "up regulation of intracellular sterol transport" EXACT []
synonym: "up-regulation of intracellular sterol transport" EXACT []
synonym: "upregulation of intracellular sterol transport" EXACT []
is_a: GO:0032373 ! positive regulation of sterol transport
is_a: GO:0032379 ! positive regulation of intracellular lipid transport
is_a: GO:0032380 ! regulation of intracellular sterol transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032366 ! intracellular sterol transport
relationship: positively_regulates GO:0032366 ! intracellular sterol transport

[Term]
id: GO:0032383
name: regulation of intracellular cholesterol transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of cholesterol within cells." [GOC:mah]
is_a: GO:0032374 ! regulation of cholesterol transport
is_a: GO:0032380 ! regulation of intracellular sterol transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032367 ! intracellular cholesterol transport
relationship: regulates GO:0032367 ! intracellular cholesterol transport

[Term]
id: GO:0032384
name: negative regulation of intracellular cholesterol transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of cholesterol within cells." [GOC:mah]
synonym: "down regulation of intracellular cholesterol transport" EXACT []
synonym: "down-regulation of intracellular cholesterol transport" EXACT []
synonym: "downregulation of intracellular cholesterol transport" EXACT []
synonym: "inhibition of intracellular cholesterol transport" NARROW []
is_a: GO:0032375 ! negative regulation of cholesterol transport
is_a: GO:0032381 ! negative regulation of intracellular sterol transport
is_a: GO:0032383 ! regulation of intracellular cholesterol transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032367 ! intracellular cholesterol transport
relationship: negatively_regulates GO:0032367 ! intracellular cholesterol transport

[Term]
id: GO:0032385
name: positive regulation of intracellular cholesterol transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of cholesterol within cells." [GOC:mah]
synonym: "activation of intracellular cholesterol transport" NARROW []
synonym: "stimulation of intracellular cholesterol transport" NARROW []
synonym: "up regulation of intracellular cholesterol transport" EXACT []
synonym: "up-regulation of intracellular cholesterol transport" EXACT []
synonym: "upregulation of intracellular cholesterol transport" EXACT []
is_a: GO:0032376 ! positive regulation of cholesterol transport
is_a: GO:0032382 ! positive regulation of intracellular sterol transport
is_a: GO:0032383 ! regulation of intracellular cholesterol transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032367 ! intracellular cholesterol transport
relationship: positively_regulates GO:0032367 ! intracellular cholesterol transport

[Term]
id: GO:0032386
name: regulation of intracellular transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah]
is_a: GO:0051049 ! regulation of transport
is_a: GO:0060341 ! regulation of cellular localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0046907 ! intracellular transport
relationship: regulates GO:0046907 ! intracellular transport

[Term]
id: GO:0032387
name: negative regulation of intracellular transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah]
synonym: "down regulation of intracellular transport" EXACT []
synonym: "down-regulation of intracellular transport" EXACT []
synonym: "downregulation of intracellular transport" EXACT []
synonym: "inhibition of intracellular transport" NARROW []
is_a: GO:0032386 ! regulation of intracellular transport
is_a: GO:0051051 ! negative regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0046907 ! intracellular transport
relationship: negatively_regulates GO:0046907 ! intracellular transport

[Term]
id: GO:0032388
name: positive regulation of intracellular transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah]
synonym: "activation of intracellular transport" NARROW []
synonym: "stimulation of intracellular transport" NARROW []
synonym: "up regulation of intracellular transport" EXACT []
synonym: "up-regulation of intracellular transport" EXACT []
synonym: "upregulation of intracellular transport" EXACT []
is_a: GO:0032386 ! regulation of intracellular transport
is_a: GO:0051050 ! positive regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0046907 ! intracellular transport
relationship: positively_regulates GO:0046907 ! intracellular transport

[Term]
id: GO:0032389
name: MutLalpha complex
namespace: cellular_component
def: "A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS2." [GOC:vk]
synonym: "MLH1/PMS2 complex" EXACT []
synonym: "MMR complex" BROAD []
synonym: "MutL-alpha complex" EXACT [CORUM:292]
is_a: GO:0032300 ! mismatch repair complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0032390
name: MutLbeta complex
namespace: cellular_component
def: "A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS1." [GOC:vk]
synonym: "MLH1/PMS1 complex" EXACT []
synonym: "MMR complex" BROAD []
is_a: GO:0032300 ! mismatch repair complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0032391
name: photoreceptor connecting cilium
namespace: cellular_component
def: "A nonmotile primary cilium that has a 9+0 microtubule array and forms the portion of the axoneme traversing the boundary between the photoreceptor inner and outer segments." [PMID:15917207, PMID:8718680]
synonym: "photoreceptor cilium" RELATED []
is_a: GO:0031513 ! nonmotile primary cilium

[Term]
id: GO:0032392
name: DNA geometric change
namespace: biological_process
def: "The process in which a transformation is induced in the geometry of a DNA double helix, resulting in a change in twist, writhe, or both, but with no change in linking number. Includes the unwinding of double-stranded DNA by helicases." [GOC:mah]
comment: Note that DNA geometric change and DNA topological change (GO:0006265) are distinct, but are usually coupled in vivo.
subset: goslim_pir
is_a: GO:0071103 ! DNA conformation change

[Term]
id: GO:0032393
name: MHC class I receptor activity
namespace: molecular_function
def: "Combining with an MHC class I protein complex to initiate a change in cellular activity. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149]
comment: Note that this term is intended for annotation of gene products that act as receptors for MHC class I protein complexes, not for components of the MHC class I protein complexes themselves.
synonym: "alpha-beta T cell receptor activity" RELATED []
synonym: "gamma-delta T cell receptor activity" RELATED []
synonym: "T cell receptor activity" RELATED []
is_a: GO:0004888 ! transmembrane signaling receptor activity
relationship: has_part GO:0042288 ! MHC class I protein binding

[Term]
id: GO:0032394
name: MHC class Ib receptor activity
namespace: molecular_function
def: "Combining with an MHC class Ib protein complex and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families." [GOC:add, GOC:signaling, ISBN:0781735149]
comment: Note that this term is intended for annotation of gene products that act as receptors for MHC class Ib protein complexes, not for components of the MHC class Ib protein complexes themselves.
synonym: "alpha-beta T cell receptor activity" RELATED []
synonym: "gamma-delta T cell receptor activity" RELATED []
synonym: "T cell receptor activity" RELATED []
is_a: GO:0004888 ! transmembrane signaling receptor activity
relationship: has_part GO:0023029 ! MHC class Ib protein binding

[Term]
id: GO:0032395
name: MHC class II receptor activity
namespace: molecular_function
def: "Combining with an MHC class II protein complex and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]
comment: Note that this term is intended for annotation of gene products that act as receptors for MHC class II protein complexes, not for components of the MHC class II protein complexes themselves.
synonym: "alpha-beta T cell receptor activity" RELATED []
synonym: "gamma-delta T cell receptor activity" RELATED []
synonym: "T cell receptor activity" RELATED []
is_a: GO:0004888 ! transmembrane signaling receptor activity
relationship: has_part GO:0042289 ! MHC class II protein binding

[Term]
id: GO:0032396
name: inhibitory MHC class I receptor activity
namespace: molecular_function
def: "Combining with a MHC class I protein complex to mediate signaling that inhibits activation of a lymphocyte." [GOC:add, PMID:11858820, PMID:9368779, PMID:9597134]
is_a: GO:0032393 ! MHC class I receptor activity

[Term]
id: GO:0032397
name: activating MHC class I receptor activity
namespace: molecular_function
def: "Combining with a MHC class I protein complex to mediate signaling that activates a lymphocyte." [GOC:add, PMID:11858820, PMID:9597134]
is_a: GO:0032393 ! MHC class I receptor activity

[Term]
id: GO:0032398
name: MHC class Ib protein complex
namespace: cellular_component
def: "A transmembrane protein complex composed of a MHC class Ib alpha chain and, in most cases, an invariant beta2-microglobin chain, and with or without a bound peptide or lipid antigen. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families." [GOC:add, ISBN:0781735149, PMID:15928678]
is_a: GO:0042611 ! MHC protein complex

[Term]
id: GO:0032399
name: HECT domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a HECT, 'Homologous to the E6-AP Carboxyl Terminus', domain of a protein." [GOC:mah, Pfam:PF00632]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0032400
name: melanosome localization
namespace: biological_process
def: "Any process in which a melanosome is transported to, and/or maintained in, a specific location within the cell." [GOC:ln]
synonym: "melanosome localisation" EXACT [GOC:mah]
is_a: GO:0051875 ! pigment granule localization

[Term]
id: GO:0032401
name: establishment of melanosome localization
namespace: biological_process
def: "The directed movement of a melanosome to a specific location." [GOC:mah]
synonym: "establishment of melanosome localisation" EXACT [GOC:mah]
is_a: GO:0051905 ! establishment of pigment granule localization
relationship: part_of GO:0032400 ! melanosome localization

[Term]
id: GO:0032402
name: melanosome transport
namespace: biological_process
def: "The directed movement of melanosomes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ln]
is_a: GO:0032400 ! melanosome localization
is_a: GO:0032401 ! establishment of melanosome localization
is_a: GO:0051904 ! pigment granule transport

[Term]
id: GO:0032403
name: protein complex binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:mah]
subset: goslim_chembl
is_a: GO:0005515 ! protein binding
is_a: GO:0044877 ! macromolecular complex binding

[Term]
id: GO:0032404
name: mismatch repair complex binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a mismatch repair complex." [GOC:vk]
is_a: GO:0032403 ! protein complex binding

[Term]
id: GO:0032405
name: MutLalpha complex binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the mismatch repair complex MutLalpha." [GOC:vk]
is_a: GO:0032404 ! mismatch repair complex binding

[Term]
id: GO:0032406
name: MutLbeta complex binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the mismatch repair complex MutLbeta." [GOC:vk]
is_a: GO:0032404 ! mismatch repair complex binding

[Term]
id: GO:0032407
name: MutSalpha complex binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the mismatch repair complex MutSalpha." [GOC:vk]
is_a: GO:0032404 ! mismatch repair complex binding

[Term]
id: GO:0032408
name: MutSbeta complex binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the mismatch repair complex MutSbeta." [GOC:vk]
is_a: GO:0032404 ! mismatch repair complex binding

[Term]
id: GO:0032409
name: regulation of transporter activity
namespace: biological_process
def: "Any process that modulates the activity of a transporter." [GOC:mah]
subset: gosubset_prok
is_a: GO:0051049 ! regulation of transport
is_a: GO:0065009 ! regulation of molecular function
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0005215 ! transporter activity
relationship: regulates GO:0005215 ! transporter activity

[Term]
id: GO:0032410
name: negative regulation of transporter activity
namespace: biological_process
def: "Any process that stops or reduces the activity of a transporter." [GOC:mah]
synonym: "down regulation of transporter activity" EXACT []
synonym: "down-regulation of transporter activity" EXACT []
synonym: "downregulation of transporter activity" EXACT []
synonym: "inhibition of transporter activity" NARROW []
is_a: GO:0032409 ! regulation of transporter activity
is_a: GO:0044092 ! negative regulation of molecular function
is_a: GO:0051051 ! negative regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0005215 ! transporter activity
relationship: negatively_regulates GO:0005215 ! transporter activity

[Term]
id: GO:0032411
name: positive regulation of transporter activity
namespace: biological_process
def: "Any process that activates or increases the activity of a transporter." [GOC:mah]
synonym: "activation of transporter activity" NARROW []
synonym: "stimulation of transporter activity" NARROW []
synonym: "up regulation of transporter activity" EXACT []
synonym: "up-regulation of transporter activity" EXACT []
synonym: "upregulation of transporter activity" EXACT []
is_a: GO:0032409 ! regulation of transporter activity
is_a: GO:0044093 ! positive regulation of molecular function
is_a: GO:0051050 ! positive regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0005215 ! transporter activity
relationship: positively_regulates GO:0005215 ! transporter activity

[Term]
id: GO:0032412
name: regulation of ion transmembrane transporter activity
namespace: biological_process
def: "Any process that modulates the activity of an ion transporter." [GOC:mah, GOC:tb]
subset: gosubset_prok
synonym: "regulation of ion transporter activity" EXACT [GOC:tb]
is_a: GO:0022898 ! regulation of transmembrane transporter activity
is_a: GO:0034765 ! regulation of ion transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0015075 ! ion transmembrane transporter activity
relationship: regulates GO:0015075 ! ion transmembrane transporter activity

[Term]
id: GO:0032413
name: negative regulation of ion transmembrane transporter activity
namespace: biological_process
def: "Any process that stops or reduces the activity of an ion transporter." [GOC:mah, GOC:tb]
synonym: "down regulation of ion transporter activity" EXACT []
synonym: "down-regulation of ion transporter activity" EXACT []
synonym: "downregulation of ion transporter activity" EXACT []
synonym: "inhibition of ion transporter activity" NARROW []
synonym: "negative regulation of ion transporter activity" EXACT [GOC:tb]
is_a: GO:0032410 ! negative regulation of transporter activity
is_a: GO:0032412 ! regulation of ion transmembrane transporter activity
is_a: GO:0034766 ! negative regulation of ion transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0015075 ! ion transmembrane transporter activity
relationship: negatively_regulates GO:0015075 ! ion transmembrane transporter activity

[Term]
id: GO:0032414
name: positive regulation of ion transmembrane transporter activity
namespace: biological_process
def: "Any process that activates or increases the activity of an ion transporter." [GOC:mah, GOC:tb]
synonym: "activation of ion transporter activity" NARROW []
synonym: "positive regulation of ion transporter activity" EXACT [GOC:tb]
synonym: "stimulation of ion transporter activity" NARROW []
synonym: "up regulation of ion transporter activity" EXACT []
synonym: "up-regulation of ion transporter activity" EXACT []
synonym: "upregulation of ion transporter activity" EXACT []
is_a: GO:0032411 ! positive regulation of transporter activity
is_a: GO:0032412 ! regulation of ion transmembrane transporter activity
is_a: GO:0034767 ! positive regulation of ion transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0015075 ! ion transmembrane transporter activity
relationship: positively_regulates GO:0015075 ! ion transmembrane transporter activity

[Term]
id: GO:0032415
name: regulation of sodium:proton antiporter activity
namespace: biological_process
def: "Any process that modulates the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)." [GOC:mah, GOC:mtg_transport]
synonym: "regulation of sodium:hydrogen antiporter activity" EXACT []
is_a: GO:0010155 ! regulation of proton transport
is_a: GO:2000649 ! regulation of sodium ion transmembrane transporter activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0015385 ! sodium:proton antiporter activity
relationship: regulates GO:0015385 ! sodium:proton antiporter activity

[Term]
id: GO:0032416
name: negative regulation of sodium:proton antiporter activity
namespace: biological_process
def: "Any process that stops or reduces the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)." [GOC:mah]
synonym: "down regulation of sodium:hydrogen antiporter activity" EXACT []
synonym: "down-regulation of sodium:hydrogen antiporter activity" EXACT []
synonym: "downregulation of sodium:hydrogen antiporter activity" EXACT []
synonym: "inhibition of sodium:hydrogen antiporter activity" NARROW []
synonym: "negative regulation of sodium:hydrogen antiporter activity" EXACT []
is_a: GO:0032415 ! regulation of sodium:proton antiporter activity
is_a: GO:2000650 ! negative regulation of sodium ion transmembrane transporter activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0015385 ! sodium:proton antiporter activity
relationship: negatively_regulates GO:0015385 ! sodium:proton antiporter activity

[Term]
id: GO:0032417
name: positive regulation of sodium:proton antiporter activity
namespace: biological_process
def: "Any process that activates or increases the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)." [GOC:mah]
synonym: "activation of sodium:hydrogen antiporter activity" NARROW []
synonym: "positive regulation of sodium:hydrogen antiporter activity" EXACT []
synonym: "stimulation of sodium:hydrogen antiporter activity" NARROW []
synonym: "up regulation of sodium:hydrogen antiporter activity" EXACT []
synonym: "up-regulation of sodium:hydrogen antiporter activity" EXACT []
synonym: "upregulation of sodium:hydrogen antiporter activity" EXACT []
is_a: GO:0032415 ! regulation of sodium:proton antiporter activity
is_a: GO:2000651 ! positive regulation of sodium ion transmembrane transporter activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0015385 ! sodium:proton antiporter activity
relationship: positively_regulates GO:0015385 ! sodium:proton antiporter activity

[Term]
id: GO:0032418
name: lysosome localization
namespace: biological_process
def: "Any process in which a lysosome is transported to, and/or maintained in, a specific location." [GOC:mah]
synonym: "lysosome localisation" EXACT [GOC:mah]
is_a: GO:0051640 ! organelle localization

[Term]
id: GO:0032419
name: extrinsic component of lysosome membrane
namespace: cellular_component
def: "The component of an lysosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah]
synonym: "extrinsic to lysosomal membrane" EXACT []
synonym: "extrinsic to lysosome membrane" EXACT []
is_a: GO:0000306 ! extrinsic component of vacuolar membrane
intersection_of: GO:0019898 ! extrinsic component of membrane
intersection_of: part_of GO:0005765 ! lysosomal membrane
relationship: part_of GO:0005765 ! lysosomal membrane

[Term]
id: GO:0032420
name: stereocilium
namespace: cellular_component
def: "An actin-based protrusion from the apical surface of auditory and vestibular hair cells and of neuromast cells. These protrusions are supported by a bundle of cross-linked actin filaments (an actin cable), oriented such that the plus (barbed) ends are at the tip of the protrusion, capped by a tip complex which bridges to the plasma. Bundles of stereocilia act as mechanosensory organelles." [GOC:ecd, PMID:15661519, PMID:7840137]
is_a: GO:0044422 ! organelle part
is_a: GO:0097458 ! neuron part
is_a: GO:0098858 ! actin-based cell projection
relationship: part_of GO:0032421 ! stereocilium bundle

[Term]
id: GO:0032421
name: stereocilium bundle
namespace: cellular_component
def: "A bundle of cross-linked stereocilia, arranged around a kinocilium on the apical surface of a sensory hair cell (e.g. a neuromast, auditory or vestibular hair cell). Stereocilium bundles act as mechanosensory organelles by responding to fluid motion or fluid pressure changes." [GOC:ecd, PMID:15661519, PMID:7840137]
subset: goslim_pir
synonym: "stereocilia bundle" EXACT []
is_a: GO:0097458 ! neuron part
is_a: GO:0098862 ! cluster of actin-based cell projections
relationship: has_part GO:0032420 ! stereocilium

[Term]
id: GO:0032422
name: purine-rich negative regulatory element binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a 30-bp purine-rich negative regulatory element; the best characterized such element is found in the first intronic region of the rat cardiac alpha-myosin heavy chain gene, and contains two palindromic high-affinity Ets-binding sites (CTTCCCTGGAAG). The presence of this element restricts expression of the gene containing it to cardiac myocytes." [GOC:mah, PMID:9819411]
synonym: "PNR element binding" BROAD []
is_a: GO:0044212 ! transcription regulatory region DNA binding
is_a: GO:1990837 ! sequence-specific double-stranded DNA binding

[Term]
id: GO:0032423
name: regulation of mismatch repair
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mismatch repair." [GOC:vk]
is_a: GO:0006282 ! regulation of DNA repair
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006298 ! mismatch repair
relationship: regulates GO:0006298 ! mismatch repair

[Term]
id: GO:0032424
name: negative regulation of mismatch repair
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mismatch repair." [GOC:vk]
synonym: "down regulation of mismatch repair" EXACT []
synonym: "down-regulation of mismatch repair" EXACT []
synonym: "downregulation of mismatch repair" EXACT []
synonym: "inhibition of mismatch repair" NARROW []
is_a: GO:0032423 ! regulation of mismatch repair
is_a: GO:0045738 ! negative regulation of DNA repair
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006298 ! mismatch repair
relationship: negatively_regulates GO:0006298 ! mismatch repair

[Term]
id: GO:0032425
name: positive regulation of mismatch repair
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mismatch repair." [GOC:vk]
synonym: "activation of mismatch repair" NARROW []
synonym: "stimulation of mismatch repair" NARROW []
synonym: "up regulation of mismatch repair" EXACT []
synonym: "up-regulation of mismatch repair" EXACT []
synonym: "upregulation of mismatch repair" EXACT []
is_a: GO:0032423 ! regulation of mismatch repair
is_a: GO:0045739 ! positive regulation of DNA repair
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006298 ! mismatch repair
relationship: positively_regulates GO:0006298 ! mismatch repair

[Term]
id: GO:0032426
name: stereocilium tip
namespace: cellular_component
def: "A distinct compartment at the tip of a stereocilium, distal to the site of attachment to the apical cell surface. It consists of a dense matrix bridging the barbed ends of the stereocilium actin filaments with the overlying plasma membrane." [GOC:ecd, PMID:17021180]
is_a: GO:0044422 ! organelle part
is_a: GO:0044463 ! cell projection part
is_a: GO:0097458 ! neuron part
relationship: part_of GO:0032420 ! stereocilium

[Term]
id: GO:0032427
name: GBD domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the GTPase protein binding domain (GDB) domain of a protein. The GBD is a short motif, including a minimum region of 16 amino acids, identified in proteins that bind to small GTPases such as Cdc42 and Rac." [GOC:mah, GOC:pg, PMID:9119069]
synonym: "Cdc42/Rac interactive binding motif binding" EXACT [PMID:9119069]
synonym: "CRIB motif binding" EXACT [PMID:9119069]
synonym: "P21-Rho-binding domain binding" EXACT [GOC:rl]
synonym: "PMD binding" EXACT [GOC:rl]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0032428
name: beta-N-acetylgalactosaminidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-beta-D-galactosaminides." [EC:3.2.1.53]
synonym: "beta-acetylgalactosaminidase activity" EXACT [EC:3.2.1.53]
synonym: "beta-D-N-acetylgalactosaminidase activity" EXACT [EC:3.2.1.53]
synonym: "beta-N-acetyl-D-galactosaminide N-acetylgalactosaminohydrolase activity" EXACT [EC:3.2.1.53]
synonym: "N-acetyl-beta-D-galactosaminidase activity" EXACT [EC:3.2.1.53]
synonym: "N-acetyl-beta-galactosaminidase activity" EXACT [EC:3.2.1.53]
synonym: "N-acetylgalactosaminidase activity" EXACT [EC:3.2.1.53]
xref: EC:3.2.1.53
xref: MetaCyc:3.2.1.53-RXN
is_a: GO:0004563 ! beta-N-acetylhexosaminidase activity

[Term]
id: GO:0032429
name: regulation of phospholipase A2 activity
namespace: biological_process
def: "Any process that modulates the activity of the enzyme phospholipase A2." [GOC:mah]
is_a: GO:0010517 ! regulation of phospholipase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004623 ! phospholipase A2 activity
relationship: regulates GO:0004623 ! phospholipase A2 activity

[Term]
id: GO:0032430
name: positive regulation of phospholipase A2 activity
namespace: biological_process
def: "Any process that activates or increases the activity of the enzyme phospholipase A2." [GOC:mah]
synonym: "activation of phospholipase A2 activity" NARROW []
synonym: "stimulation of phospholipase A2 activity" NARROW []
synonym: "up regulation of phospholipase A2 activity" EXACT []
synonym: "up-regulation of phospholipase A2 activity" EXACT []
synonym: "upregulation of phospholipase A2 activity" EXACT []
is_a: GO:0010518 ! positive regulation of phospholipase activity
is_a: GO:0032429 ! regulation of phospholipase A2 activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004623 ! phospholipase A2 activity
relationship: positively_regulates GO:0004623 ! phospholipase A2 activity

[Term]
id: GO:0032431
name: activation of phospholipase A2 activity
namespace: biological_process
def: "Any process that initiates the activity of the inactive enzyme phospholipase A2." [GOC:mah]
synonym: "phospholipase A2 activation" EXACT []
is_a: GO:0032430 ! positive regulation of phospholipase A2 activity

[Term]
id: GO:0032432
name: actin filament bundle
namespace: cellular_component
alt_id: GO:0000141
alt_id: GO:0030482
def: "An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:mah]
synonym: "actin cable" RELATED [GOC:mah]
is_a: GO:0044430 ! cytoskeletal part
relationship: has_part GO:0005884 ! actin filament
relationship: part_of GO:0015629 ! actin cytoskeleton

[Term]
id: GO:0032433
name: filopodium tip
namespace: cellular_component
def: "The end of a filopodium distal to the body of the cell." [GOC:mah]
is_a: GO:0044463 ! cell projection part
relationship: part_of GO:0030175 ! filopodium

[Term]
id: GO:0032434
name: regulation of proteasomal ubiquitin-dependent protein catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah]
is_a: GO:0061136 ! regulation of proteasomal protein catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process
relationship: regulates GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process

[Term]
id: GO:0032435
name: negative regulation of proteasomal ubiquitin-dependent protein catabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah]
synonym: "down regulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT []
synonym: "down-regulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT []
synonym: "downregulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT []
synonym: "inhibition of proteasomal ubiquitin-dependent protein catabolic process" NARROW []
is_a: GO:0032434 ! regulation of proteasomal ubiquitin-dependent protein catabolic process
is_a: GO:1901799 ! negative regulation of proteasomal protein catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process
relationship: negatively_regulates GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process

[Term]
id: GO:0032436
name: positive regulation of proteasomal ubiquitin-dependent protein catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah]
synonym: "activation of proteasomal ubiquitin-dependent protein catabolic process" NARROW []
synonym: "stimulation of proteasomal ubiquitin-dependent protein catabolic process" NARROW []
synonym: "up regulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT []
synonym: "up-regulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT []
synonym: "upregulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT []
is_a: GO:0032434 ! regulation of proteasomal ubiquitin-dependent protein catabolic process
is_a: GO:1901800 ! positive regulation of proteasomal protein catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process
relationship: positively_regulates GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process

[Term]
id: GO:0032437
name: cuticular plate
namespace: cellular_component
def: "A dense network of actin filaments found beneath the apical cell surface of hair cells, and into which stereocilia are inserted." [PMID:12485990, PMID:2592408, PMID:8071151]
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044448 ! cell cortex part
is_a: GO:0097458 ! neuron part
relationship: part_of GO:0030864 ! cortical actin cytoskeleton

[Term]
id: GO:0032438
name: melanosome organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a melanosome. A melanosome is a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored." [GOC:vk]
synonym: "melanosome organisation" EXACT [GOC:mah]
synonym: "melanosome organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0048753 ! pigment granule organization

[Term]
id: GO:0032439
name: endosome localization
namespace: biological_process
def: "Any process in which endosomes are transported to, and/or maintained in, a specific location within the cell." [GOC:ecd]
synonym: "endosome localisation" EXACT [GOC:mah]
is_a: GO:0051640 ! organelle localization

[Term]
id: GO:0032440
name: 2-alkenal reductase [NAD(P)] activity
namespace: molecular_function
def: "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
synonym: "n-alkanal:NAD(P)+ 2-oxidoreductase activity" EXACT [EC:1.3.1.74]
synonym: "NAD(P)H-dependent alkenal/one oxidoreductase activity" EXACT [EC:1.3.1.74]
xref: EC:1.3.1.74
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0032441
name: pheophorbide a oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: pheophorbide a + reduced ferredoxin + 2 O2 = red chlorophyll catabolite + oxidized ferredoxin + H2O." [PMID:14657372, PMID:16448336]
xref: EC:1.8.-.-
xref: MetaCyc:RXN-7740
is_a: GO:0016730 ! oxidoreductase activity, acting on iron-sulfur proteins as donors

[Term]
id: GO:0032442
name: phenylcoumaran benzylic ether reductase activity
namespace: molecular_function
def: "Catalysis of the NADPH-dependent 7-O-4' reduction of phenylcoumaran lignans to the corresponding diphenols; for example, catalysis of the reaction: dehydrodiconiferyl alcohol + NADPH + H+ = isodihydrodehydrodiconiferyl alcohol + NADP+." [PMID:11030549, PMID:13129921]
synonym: "PCBER activity" EXACT []
xref: EC:1.1.1.-
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0032443
name: regulation of ergosterol biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ergosterol." [GOC:mah]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0050810 ! regulation of steroid biosynthetic process
is_a: GO:1902930 ! regulation of alcohol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006696 ! ergosterol biosynthetic process
relationship: regulates GO:0006696 ! ergosterol biosynthetic process

[Term]
id: GO:0032444
name: activin responsive factor complex
namespace: cellular_component
def: "A transcriptionally active complex that binds to an activin response element (ARE) in the promoter of target genes, and is composed of two SMAD2 proteins, one SMAD4 protein and a Forkhead activin signal transducer (FAST) transcription factor." [PMID:12374795, PMID:9288972]
comment: Note that this term should not be confused with any of the molecular function and biological process terms that refer to the small GTPase ARF (ADP-ribosylation factor).
synonym: "ARF complex" EXACT []
is_a: GO:0090575 ! RNA polymerase II transcription factor complex

[Term]
id: GO:0032445
name: fructose import
namespace: biological_process
def: "The directed movement of the hexose monosaccharide fructose into a cell or organelle." [GOC:mah]
subset: gosubset_prok
synonym: "fructose uptake" EXACT [GOC:dph, GOC:tb]
is_a: GO:0015755 ! fructose transport

[Term]
id: GO:0032446
name: protein modification by small protein conjugation
namespace: biological_process
def: "A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein." [GOC:mah]
is_a: GO:0070647 ! protein modification by small protein conjugation or removal

[Term]
id: GO:0032447
name: protein urmylation
namespace: biological_process
def: "Covalent attachment of the ubiquitin-like protein URM1 to another protein." [GOC:vw]
is_a: GO:0032446 ! protein modification by small protein conjugation

[Term]
id: GO:0032448
name: DNA hairpin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with DNA containing a hairpin. A hairpin structure forms when a DNA strand folds back on itself and intrachain base pairing occurs between inverted repeat sequences." [GOC:mah, ISBN:0198506732]
is_a: GO:0000217 ! DNA secondary structure binding

[Term]
id: GO:0032449
name: CBM complex
namespace: cellular_component
def: "A protein complex comprising Carma1, Bcl10 and MALT1; plays a role in signal transduction during NF-kappaB activation." [PMID:12909454]
synonym: "CARMA1-BCL10-Malt1 complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0032450
name: maltose alpha-glucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-maltose + H2O = 2 alpha-D-glucose." [MetaCyc:RXN-2141]
synonym: "maltase activity" EXACT []
xref: EC:3.2.1.20
xref: MetaCyc:RXN-2141
is_a: GO:0090599 ! alpha-glucosidase activity
relationship: part_of GO:0000023 ! maltose metabolic process

[Term]
id: GO:0032451
name: demethylase activity
namespace: molecular_function
def: "Catalysis of the removal of a methyl group from a substrate." [GOC:mah]
subset: goslim_pir
is_a: GO:0003824 ! catalytic activity
relationship: part_of GO:0070988 ! demethylation

[Term]
id: GO:0032452
name: histone demethylase activity
namespace: molecular_function
def: "Catalysis of the removal of a methyl group from a histone." [GOC:mah]
is_a: GO:0032451 ! demethylase activity
relationship: part_of GO:0016577 ! histone demethylation

[Term]
id: GO:0032453
name: histone demethylase activity (H3-K4 specific)
namespace: molecular_function
def: "Catalysis of the removal of a methyl group from lysine at position 4 of the histone H3 protein." [GOC:mah]
is_a: GO:0032452 ! histone demethylase activity
relationship: part_of GO:0034720 ! histone H3-K4 demethylation

[Term]
id: GO:0032454
name: histone demethylase activity (H3-K9 specific)
namespace: molecular_function
def: "Catalysis of the reaction: histone H3 N6-methyl-L-lysine (position 9) + alpha-ketoglutarate + O2 = succinate + CO2 + formaldehyde + lysine. This reaction is the removal of a methyl group from lysine at position 9 of the histone H3 protein." [PMID:16362057]
xref: Reactome:REACT_25371 "JMJD1C demethylates H3K9 mono- and di-methylation, Homo sapiens"
is_a: GO:0032452 ! histone demethylase activity
relationship: part_of GO:0033169 ! histone H3-K9 demethylation

[Term]
id: GO:0032455
name: nerve growth factor processing
namespace: biological_process
def: "The generation of a mature nerve growth factor (NGF) by proteolysis of a precursor." [GOC:mah, PMID:8615794]
synonym: "beta-nerve growth factor processing" EXACT [PR:000011194]
synonym: "NGF processing" EXACT [PR:000011194]
xref: Reactome:REACT_105501 "NGF processing, Taeniopygia guttata"
xref: Reactome:REACT_107921 "NGF processing, Gallus gallus"
xref: Reactome:REACT_110528 "NGF processing, Bos taurus"
xref: Reactome:REACT_11062 "NGF processing, Homo sapiens"
xref: Reactome:REACT_34185 "NGF processing, Sus scrofa"
xref: Reactome:REACT_80539 "NGF processing, Canis familiaris"
xref: Reactome:REACT_83522 "NGF processing, Mus musculus"
xref: Reactome:REACT_85976 "NGF processing, Rattus norvegicus"
xref: Reactome:REACT_88690 "NGF processing, Xenopus tropicalis"
xref: Reactome:REACT_96202 "NGF processing, Danio rerio"
is_a: GO:0016486 ! peptide hormone processing

[Term]
id: GO:0032456
name: endocytic recycling
namespace: biological_process
def: "The directed movement of membrane-bounded vesicles from recycling endosomes back to the plasma membrane where they are recycled for further rounds of transport." [GOC:ecd, PMID:16473635]
synonym: "retrograde transport of endocytic vesicles" RELATED []
is_a: GO:0016192 ! vesicle-mediated transport
is_a: GO:0016197 ! endosomal transport

[Term]
id: GO:0032457
name: fast endocytic recycling
namespace: biological_process
def: "The directed movement of membrane-bounded vesicles from peripheral endocytic compartments back to the plasma membrane where they are recycled for further rounds of transport." [GOC:ecd, PMID:16473635]
synonym: "direct endocytic recycling" EXACT []
is_a: GO:0032456 ! endocytic recycling

[Term]
id: GO:0032458
name: slow endocytic recycling
namespace: biological_process
def: "The directed movement of membrane-bounded vesicles from deep (non-peripheral) compartments endocytic compartments back to the plasma membrane where they are recycled for further rounds of transport." [GOC:ecd, PMID:16473635]
is_a: GO:0032456 ! endocytic recycling

[Term]
id: GO:0032459
name: regulation of protein oligomerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein oligomerization." [GOC:mah]
subset: gosubset_prok
is_a: GO:0043254 ! regulation of protein complex assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051259 ! protein oligomerization
relationship: regulates GO:0051259 ! protein oligomerization

[Term]
id: GO:0032460
name: negative regulation of protein oligomerization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein oligomerization." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation of protein oligomerization" EXACT []
synonym: "down-regulation of protein oligomerization" EXACT []
synonym: "downregulation of protein oligomerization" EXACT []
synonym: "inhibition of protein oligomerization" NARROW []
is_a: GO:0031333 ! negative regulation of protein complex assembly
is_a: GO:0032459 ! regulation of protein oligomerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051259 ! protein oligomerization
relationship: negatively_regulates GO:0051259 ! protein oligomerization

[Term]
id: GO:0032461
name: positive regulation of protein oligomerization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein oligomerization." [GOC:mah]
subset: gosubset_prok
synonym: "activation of protein oligomerization" NARROW []
synonym: "induction of protein oligomerization" RELATED []
synonym: "stimulation of protein oligomerization" NARROW []
synonym: "up regulation of protein oligomerization" EXACT []
synonym: "up-regulation of protein oligomerization" EXACT []
synonym: "upregulation of protein oligomerization" EXACT []
is_a: GO:0031334 ! positive regulation of protein complex assembly
is_a: GO:0032459 ! regulation of protein oligomerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051259 ! protein oligomerization
relationship: positively_regulates GO:0051259 ! protein oligomerization

[Term]
id: GO:0032462
name: regulation of protein homooligomerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein homooligomerization." [GOC:mah]
subset: gosubset_prok
is_a: GO:0032459 ! regulation of protein oligomerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051260 ! protein homooligomerization
relationship: regulates GO:0051260 ! protein homooligomerization

[Term]
id: GO:0032463
name: negative regulation of protein homooligomerization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein homooligomerization." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation of protein homooligomerization" EXACT []
synonym: "down-regulation of protein homooligomerization" EXACT []
synonym: "downregulation of protein homooligomerization" EXACT []
synonym: "inhibition of protein homooligomerization" NARROW []
is_a: GO:0032460 ! negative regulation of protein oligomerization
is_a: GO:0032462 ! regulation of protein homooligomerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051260 ! protein homooligomerization
relationship: negatively_regulates GO:0051260 ! protein homooligomerization

[Term]
id: GO:0032464
name: positive regulation of protein homooligomerization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein homooligomerization." [GOC:mah]
subset: gosubset_prok
synonym: "activation of protein homooligomerization" NARROW []
synonym: "induction of protein homooligomerization" RELATED []
synonym: "stimulation of protein homooligomerization" NARROW []
synonym: "up regulation of protein homooligomerization" EXACT []
synonym: "up-regulation of protein homooligomerization" EXACT []
synonym: "upregulation of protein homooligomerization" EXACT []
is_a: GO:0032461 ! positive regulation of protein oligomerization
is_a: GO:0032462 ! regulation of protein homooligomerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051260 ! protein homooligomerization
relationship: positively_regulates GO:0051260 ! protein homooligomerization

[Term]
id: GO:0032465
name: regulation of cytokinesis
namespace: biological_process
alt_id: GO:0071775
def: "Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells." [GOC:mah]
synonym: "regulation of cell cycle cytokinesis" EXACT []
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0051302 ! regulation of cell division
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000910 ! cytokinesis
relationship: regulates GO:0000910 ! cytokinesis

[Term]
id: GO:0032466
name: negative regulation of cytokinesis
namespace: biological_process
alt_id: GO:0071776
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells." [GOC:mah]
synonym: "down regulation of cytokinesis" EXACT []
synonym: "down-regulation of cytokinesis" EXACT []
synonym: "downregulation of cytokinesis" EXACT []
synonym: "inhibition of cytokinesis" NARROW []
synonym: "negative regulation of cell cycle cytokinesis" RELATED []
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0032465 ! regulation of cytokinesis
is_a: GO:0051782 ! negative regulation of cell division
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000910 ! cytokinesis
relationship: negatively_regulates GO:0000910 ! cytokinesis

[Term]
id: GO:0032467
name: positive regulation of cytokinesis
namespace: biological_process
alt_id: GO:0071777
def: "Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells." [GOC:mah]
synonym: "activation of cytokinesis" NARROW []
synonym: "positive regulation of cell cycle cytokinesis" RELATED []
synonym: "stimulation of cytokinesis" NARROW []
synonym: "up regulation of cytokinesis" EXACT []
synonym: "up-regulation of cytokinesis" EXACT []
synonym: "upregulation of cytokinesis" EXACT []
is_a: GO:0032465 ! regulation of cytokinesis
is_a: GO:0051781 ! positive regulation of cell division
is_a: GO:0090068 ! positive regulation of cell cycle process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000910 ! cytokinesis
relationship: positively_regulates GO:0000910 ! cytokinesis

[Term]
id: GO:0032468
name: Golgi calcium ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of calcium ions within the Golgi apparatus of a cell or between the Golgi and its surroundings." [GOC:mah]
synonym: "calcium ion homeostasis in Golgi" EXACT []
synonym: "Golgi calcium ion concentration regulation" EXACT []
synonym: "regulation of calcium ion concentration in Golgi" EXACT []
synonym: "regulation of Golgi calcium ion concentration" EXACT []
is_a: GO:0006874 ! cellular calcium ion homeostasis
intersection_of: GO:0055074 ! calcium ion homeostasis
intersection_of: occurs_in GO:0005794 ! Golgi apparatus
relationship: occurs_in GO:0005794 ! Golgi apparatus

[Term]
id: GO:0032469
name: endoplasmic reticulum calcium ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of calcium ions within the endoplasmic reticulum of a cell or between the endoplasmic reticulum and its surroundings." [GOC:mah]
synonym: "calcium ion homeostasis in endoplasmic reticulum" EXACT []
synonym: "calcium ion homeostasis in ER" EXACT []
synonym: "endoplasmic reticulum calcium ion concentration regulation" EXACT []
synonym: "ER calcium ion concentration regulation" EXACT []
synonym: "ER calcium ion homeostasis" EXACT []
synonym: "regulation of calcium ion concentration in endoplasmic reticulum" EXACT []
synonym: "regulation of calcium ion concentration in ER" EXACT []
synonym: "regulation of endoplasmic reticulum calcium ion concentration" EXACT []
synonym: "regulation of ER calcium ion concentration" EXACT []
is_a: GO:0006874 ! cellular calcium ion homeostasis
intersection_of: GO:0055074 ! calcium ion homeostasis
intersection_of: occurs_in GO:0005783 ! endoplasmic reticulum
relationship: occurs_in GO:0005783 ! endoplasmic reticulum

[Term]
id: GO:0032470
name: positive regulation of endoplasmic reticulum calcium ion concentration
namespace: biological_process
def: "Any process that increases the concentration of calcium ions in the endoplasmic reticulum." [GOC:mah]
synonym: "elevation of calcium ion concentration in endoplasmic reticulum" EXACT []
synonym: "elevation of endoplasmic reticulum calcium ion concentration" EXACT []
synonym: "elevation of ER calcium ion concentration" EXACT []
synonym: "endoplasmic reticulum calcium ion concentration elevation" EXACT []
is_a: GO:0032469 ! endoplasmic reticulum calcium ion homeostasis

[Term]
id: GO:0032471
name: negative regulation of endoplasmic reticulum calcium ion concentration
namespace: biological_process
def: "Any process that decreases the concentration of calcium ions in the endoplasmic reticulum." [GOC:mah]
synonym: "endoplasmic reticulum calcium ion concentration reduction" EXACT []
synonym: "ER calcium ion concentration reduction" EXACT []
synonym: "reduction of calcium ion concentration in endoplasmic reticulum" EXACT []
synonym: "reduction of calcium ion concentration in ER" EXACT []
synonym: "reduction of endoplasmic reticulum calcium ion concentration" EXACT []
synonym: "reduction of ER calcium ion concentration" EXACT []
is_a: GO:0032469 ! endoplasmic reticulum calcium ion homeostasis

[Term]
id: GO:0032472
name: Golgi calcium ion transport
namespace: biological_process
def: "The directed movement of calcium ions (Ca2+) into, out of or within the Golgi apparatus." [GOC:mah]
synonym: "Golgi calcium transport" EXACT []
is_a: GO:0006816 ! calcium ion transport
is_a: GO:1902582 ! single-organism intracellular transport

[Term]
id: GO:0032473
name: cytoplasmic side of mitochondrial outer membrane
namespace: cellular_component
def: "The external (cytoplasmic) face of the mitochondrial outer membrane." [GOC:mah]
comment: In GO, 'external side' still refers to part of the membrane and does not refer to components beyond (outside of) the membrane.
synonym: "cytosolic side of mitochondrial outer membrane" EXACT []
synonym: "external leaflet of mitochondrial outer membrane" EXACT [GOC:ab]
synonym: "external side of mitochondrial envelope" RELATED []
synonym: "external side of mitochondrial outer membrane" EXACT []
is_a: GO:0044455 ! mitochondrial membrane part
is_a: GO:0098562 ! cytoplasmic side of membrane
relationship: part_of GO:0005741 ! mitochondrial outer membrane

[Term]
id: GO:0032474
name: otolith morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of an otolith are generated and organized." [GOC:dgh]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0042472 ! inner ear morphogenesis
relationship: part_of GO:0048840 ! otolith development

[Term]
id: GO:0032475
name: otolith formation
namespace: biological_process
def: "The process that gives rise to an otolith. This process pertains to the initial formation of a structure from unspecified parts." [GOC:dgh]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0032474 ! otolith morphogenesis

[Term]
id: GO:0032476
name: decaprenyl diphosphate synthase complex
namespace: cellular_component
def: "A complex that possesses di-trans,poly-cis-decaprenylcistransferase activity; involved in ubiquinone biosynthesis." [GOC:mah, PMID:14519123]
subset: goslim_pir
is_a: GO:1990234 ! transferase complex

[Term]
id: GO:0032477
name: homodimeric decaprenyl diphosphate synthase complex
namespace: cellular_component
def: "A homodimeric complex that possesses di-trans,poly-cis-decaprenylcistransferase activity; involved in ubiquinone biosynthesis." [PMID:14519123]
is_a: GO:0032476 ! decaprenyl diphosphate synthase complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0032478
name: heterotetrameric decaprenyl diphosphate synthase complex
namespace: cellular_component
def: "A heterotetrameric complex located in the mitochondrial inner membrane that possesses di-trans,poly-cis-decaprenylcistransferase activity; involved in ubiquinone biosynthesis. In S. pombe it is a heterotetramer of Dlp1 and Dps1." [PMID:14519123]
is_a: GO:0032476 ! decaprenyl diphosphate synthase complex
is_a: GO:0098800 ! inner mitochondrial membrane protein complex
relationship: part_of GO:0005743 ! mitochondrial inner membrane

[Term]
id: GO:0032479
name: regulation of type I interferon production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interferon type I production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:mah]
synonym: "regulation of type I IFN production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032606 ! type I interferon production
relationship: regulates GO:0032606 ! type I interferon production

[Term]
id: GO:0032480
name: negative regulation of type I interferon production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:mah]
synonym: "down regulation of type I interferon production" EXACT []
synonym: "down-regulation of type I interferon production" EXACT []
synonym: "downregulation of type I interferon production" EXACT []
synonym: "inhibition of type I interferon production" NARROW []
synonym: "negative regulation of type I IFN production" EXACT []
xref: Reactome:REACT_25271 "Negative regulators of RIG-I/MDA5 signaling, Homo sapiens"
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032479 ! regulation of type I interferon production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032606 ! type I interferon production
relationship: negatively_regulates GO:0032606 ! type I interferon production

[Term]
id: GO:0032481
name: positive regulation of type I interferon production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:mah]
synonym: "activation of type I interferon production" NARROW []
synonym: "positive regulation of type I IFN production" EXACT []
synonym: "stimulation of type I interferon production" NARROW []
synonym: "up regulation of type I interferon production" EXACT []
synonym: "up-regulation of type I interferon production" EXACT []
synonym: "upregulation of type I interferon production" EXACT []
xref: Reactome:REACT_75832 "TRAF mediated activation of IRF, Gallus gallus"
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032479 ! regulation of type I interferon production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032606 ! type I interferon production
relationship: positively_regulates GO:0032606 ! type I interferon production

[Term]
id: GO:0032482
name: Rab protein signal transduction
namespace: biological_process
def: "A series of molecular signals within the cell that are mediated by a member of the Rab family of proteins switching to a GTP-bound active state." [GOC:mah]
is_a: GO:0007265 ! Ras protein signal transduction

[Term]
id: GO:0032483
name: regulation of Rab protein signal transduction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Rab protein signal transduction." [GOC:mah]
is_a: GO:0046578 ! regulation of Ras protein signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032482 ! Rab protein signal transduction
relationship: regulates GO:0032482 ! Rab protein signal transduction

[Term]
id: GO:0032484
name: Ral protein signal transduction
namespace: biological_process
def: "A series of molecular signals within the cell that are mediated by a member of the Ral family of proteins switching to a GTP-bound active state." [GOC:mah]
is_a: GO:0007265 ! Ras protein signal transduction

[Term]
id: GO:0032485
name: regulation of Ral protein signal transduction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Ral protein signal transduction." [GOC:mah]
is_a: GO:0046578 ! regulation of Ras protein signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032484 ! Ral protein signal transduction
relationship: regulates GO:0032484 ! Ral protein signal transduction

[Term]
id: GO:0032486
name: Rap protein signal transduction
namespace: biological_process
def: "A series of molecular signals within the cell that are mediated by a member of the Rap family of proteins switching to a GTP-bound active state." [GOC:mah]
is_a: GO:0007265 ! Ras protein signal transduction

[Term]
id: GO:0032487
name: regulation of Rap protein signal transduction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Rap protein signal transduction." [GOC:mah]
is_a: GO:0046578 ! regulation of Ras protein signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032486 ! Rap protein signal transduction
relationship: regulates GO:0032486 ! Rap protein signal transduction

[Term]
id: GO:0032488
name: Cdc42 protein signal transduction
namespace: biological_process
def: "A series of molecular signals within the cell that are mediated by the Cdc42 protein switching to a GTP-bound active state." [GOC:mah, PMID:18558478]
synonym: "Cdc42 signaling" RELATED [GOC:vw]
synonym: "Cdc42 signaling pathway" RELATED [GOC:vw]
synonym: "cdc42 signalling pathway" RELATED [GOC:vw]
is_a: GO:0007266 ! Rho protein signal transduction

[Term]
id: GO:0032489
name: regulation of Cdc42 protein signal transduction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Cdc42 protein signal transduction." [GOC:mah]
is_a: GO:0035023 ! regulation of Rho protein signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032488 ! Cdc42 protein signal transduction
relationship: regulates GO:0032488 ! Cdc42 protein signal transduction

[Term]
id: GO:0032490
name: detection of molecule of bacterial origin
namespace: biological_process
def: "The series of events in which a stimulus from a molecule of bacterial origin is received and converted into a molecular signal." [GOC:add, GOC:rl]
synonym: "detection of bacteria associated molecule" EXACT []
synonym: "detection of bacterial associated molecule" EXACT []
synonym: "detection of bacterium associated molecule" EXACT []
is_a: GO:0002237 ! response to molecule of bacterial origin
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0098581 ! detection of external biotic stimulus

[Term]
id: GO:0032491
name: detection of molecule of fungal origin
namespace: biological_process
def: "The series of events in which a stimulus from a molecule of fungal origin is received and converted into a molecular signal." [GOC:mah, GOC:rl]
synonym: "detection of fungal associated molecule" EXACT []
synonym: "detection of fungus associated molecule" EXACT []
is_a: GO:0002238 ! response to molecule of fungal origin
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0098581 ! detection of external biotic stimulus

[Term]
id: GO:0032492
name: detection of molecule of oomycetes origin
namespace: biological_process
def: "The series of events in which a stimulus from a molecule of oomycetes origin is received and converted into a molecular signal." [GOC:mah, GOC:rl]
synonym: "detection of oomycetes associated molecule" EXACT []
is_a: GO:0002240 ! response to molecule of oomycetes origin
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0098581 ! detection of external biotic stimulus

[Term]
id: GO:0032493
name: response to bacterial lipoprotein
namespace: biological_process
def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacterial lipoprotein stimulus." [GOC:add, PMID:12077222]
is_a: GO:0002237 ! response to molecule of bacterial origin

[Term]
id: GO:0032494
name: response to peptidoglycan
namespace: biological_process
def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidoglycan stimulus. Peptidoglycan is a bacterial cell wall macromolecule." [GOC:add, ISBN:0721601464]
is_a: GO:0002237 ! response to molecule of bacterial origin
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0032495
name: response to muramyl dipeptide
namespace: biological_process
def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan." [GOC:add]
is_a: GO:1901652 ! response to peptide

[Term]
id: GO:0032496
name: response to lipopolysaccharide
namespace: biological_process
def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria." [GOC:add, ISBN:0721601464]
synonym: "response to endotoxin" BROAD [GOC:sl]
synonym: "response to LPS" EXACT []
is_a: GO:0002237 ! response to molecule of bacterial origin
is_a: GO:0033993 ! response to lipid
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0032497
name: detection of lipopolysaccharide
namespace: biological_process
def: "The series of events in which a lipopolysaccharide stimulus is received by a cell and converted into a molecular signal. Lipopolysaccharide is a major component of the cell wall of gram-negative bacteria." [GOC:add, PMID:15998797]
synonym: "detection of LPS" EXACT []
is_a: GO:0032490 ! detection of molecule of bacterial origin
is_a: GO:0032496 ! response to lipopolysaccharide

[Term]
id: GO:0032498
name: detection of muramyl dipeptide
namespace: biological_process
def: "The series of events in which a muramyl dipeptide stimulus is received by a cell and converted into a molecular signal. Muramyl dipeptide is derived from peptidoglycan." [GOC:rl, PMID:15998797]
is_a: GO:0032495 ! response to muramyl dipeptide
is_a: GO:0032499 ! detection of peptidoglycan

[Term]
id: GO:0032499
name: detection of peptidoglycan
namespace: biological_process
def: "The series of events in which a peptidoglycan stimulus is received by a cell and converted into a molecular signal. Peptidoglycan is a bacterial cell wall macromolecule." [GOC:add, ISBN:0721601464]
is_a: GO:0032490 ! detection of molecule of bacterial origin
is_a: GO:0032494 ! response to peptidoglycan

[Term]
id: GO:0032500
name: muramyl dipeptide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently, in a non-covalent manner, with muramyl dipeptide; muramyl dipeptide is derived from peptidoglycan." [GOC:rl]
is_a: GO:0042277 ! peptide binding
is_a: GO:0097367 ! carbohydrate derivative binding

[Term]
id: GO:0032501
name: multicellular organismal process
namespace: biological_process
alt_id: GO:0050874
def: "Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]
subset: goslim_pir
synonym: "organismal physiological process" EXACT []
is_a: GO:0008150 ! biological_process
disjoint_from: GO:0044848 ! biological phase

[Term]
id: GO:0032502
name: developmental process
namespace: biological_process
def: "A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete]
subset: goslim_aspergillus
subset: goslim_pir
subset: gosubset_prok
synonym: "development" NARROW []
is_a: GO:0008150 ! biological_process
disjoint_from: GO:0044848 ! biological phase

[Term]
id: GO:0032504
name: multicellular organism reproduction
namespace: biological_process
def: "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
is_a: GO:0000003 ! reproduction
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0032505
name: reproduction of a single-celled organism
namespace: biological_process
def: "The biological process in which new individuals are produced by one or two single-celled organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete]
subset: gosubset_prok
is_a: GO:0000003 ! reproduction

[Term]
id: GO:0032506
name: cytokinetic process
namespace: biological_process
def: "A cellular process that is involved in cytokinesis (the division of the cytoplasm of a cell and its separation into two daughter cells)." [GOC:bf, GOC:isa_complete, GOC:mah]
subset: gosubset_prok
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0000910 ! cytokinesis

[Term]
id: GO:0032507
name: maintenance of protein location in cell
namespace: biological_process
def: "Any process in which a protein is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere." [GOC:isa_complete, GOC:mah]
synonym: "maintenance of protein localization in cell" RELATED [GOC:dph, GOC:tb]
is_a: GO:0045185 ! maintenance of protein location
is_a: GO:0051651 ! maintenance of location in cell
intersection_of: GO:0045185 ! maintenance of protein location
intersection_of: occurs_in GO:0005623 ! cell
relationship: occurs_in GO:0005623 ! cell
relationship: part_of GO:0034613 ! cellular protein localization

[Term]
id: GO:0032508
name: DNA duplex unwinding
namespace: biological_process
def: "The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands." [GOC:isa_complete, GOC:mah]
comment: Note that this term refers to a geometric change in DNA conformation, and should not be confused with 'DNA topological change ; GO:0006265'.
synonym: "DNA unwinding" EXACT []
synonym: "duplex DNA melting" EXACT []
is_a: GO:0032392 ! DNA geometric change

[Term]
id: GO:0032509
name: endosome transport via multivesicular body sorting pathway
namespace: biological_process
def: "The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment." [GOC:mah, PMID:12461556, PMID:16689637]
synonym: "endosome transport via MVB sorting pathway" EXACT []
is_a: GO:0016197 ! endosomal transport
relationship: has_part GO:0071985 ! multivesicular body sorting pathway

[Term]
id: GO:0032510
name: endosome to lysosome transport via multivesicular body sorting pathway
namespace: biological_process
def: "The directed movement of substances from endosomes to lysosomes by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the lysosome." [GOC:mah, PMID:12461556, PMID:16689637]
synonym: "endosome to lysosome transport via MVB sorting pathway" EXACT []
is_a: GO:0008333 ! endosome to lysosome transport
is_a: GO:0032509 ! endosome transport via multivesicular body sorting pathway

[Term]
id: GO:0032511
name: late endosome to vacuole transport via multivesicular body sorting pathway
namespace: biological_process
def: "The directed movement of substances from endosomes to vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the vacuole." [GOC:mah, PMID:12461556, PMID:16689637]
synonym: "endosome to vacuole transport via MVB sorting pathway" EXACT []
is_a: GO:0032509 ! endosome transport via multivesicular body sorting pathway
is_a: GO:0045324 ! late endosome to vacuole transport

[Term]
id: GO:0032512
name: regulation of protein phosphatase type 2B activity
namespace: biological_process
def: "Any process that modulates the activity of the enzyme protein phosphatase type 2B." [GOC:mah]
synonym: "regulation of calcineurin activity" EXACT []
synonym: "regulation of protein phosphatase 3 activity" RELATED [GOC:dph, GOC:rl]
is_a: GO:0043666 ! regulation of phosphoprotein phosphatase activity

[Term]
id: GO:0032513
name: negative regulation of protein phosphatase type 2B activity
namespace: biological_process
def: "Any process that stops or reduces the activity of the enzyme protein phosphatase type 2B." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation of calcineurin activity" EXACT [GOC:dph, GOC:rl]
synonym: "down regulation of protein phosphatase 3 activity" RELATED [GOC:dph, GOC:rl]
synonym: "down regulation of protein phosphatase type 2B activity" EXACT []
synonym: "down-regulation of protein phosphatase type 2B activity" EXACT []
synonym: "downregulation of calcineurin activity" EXACT [GOC:dph, GOC:rl]
synonym: "downregulation of protein phosphatase 3 activity" RELATED [GOC:dph, GOC:rl]
synonym: "downregulation of protein phosphatase type 2B activity" EXACT []
synonym: "inhibition of calcineurin activity" NARROW [GOC:dph, GOC:rl]
synonym: "inhibition of protein phosphatase 3 activity" RELATED [GOC:dph, GOC:rl]
synonym: "inhibition of protein phosphatase type 2B activity" NARROW []
synonym: "negative regulation of calcineurin activity" EXACT []
synonym: "regulation of protein phosphatase 3 activity" RELATED [GOC:dph, GOC:rl]
is_a: GO:0032512 ! regulation of protein phosphatase type 2B activity
is_a: GO:0032515 ! negative regulation of phosphoprotein phosphatase activity

[Term]
id: GO:0032514
name: positive regulation of protein phosphatase type 2B activity
namespace: biological_process
def: "Any process that activates or increases the activity of the enzyme protein phosphatase type 2B." [GOC:mah]
subset: gosubset_prok
synonym: "activation of calcineurin activity" NARROW [GOC:dph, GOC:rl]
synonym: "activation of protein phosphatase 3 activity" RELATED [GOC:dph, GOC:rl]
synonym: "activation of protein phosphatase type 2B activity" NARROW []
synonym: "calcineurin activation" EXACT []
synonym: "positive regulation of calcineurin activity" EXACT []
synonym: "positive regulation of protein phosphatase 3 activity" RELATED [GOC:dph, GOC:rl]
synonym: "stimulation of protein phosphatase type 2B activity" NARROW []
synonym: "up regulation of calcineurin activity" EXACT [GOC:dph, GOC:rl]
synonym: "up regulation of protein phosphatase 3 activity" RELATED [GOC:dph, GOC:rl]
synonym: "up regulation of protein phosphatase type 2B activity" EXACT []
synonym: "up-regulation of protein phosphatase type 2B activity" EXACT []
synonym: "upregulation of protein phosphatase type 2B activity" EXACT []
is_a: GO:0032512 ! regulation of protein phosphatase type 2B activity
is_a: GO:0032516 ! positive regulation of phosphoprotein phosphatase activity

[Term]
id: GO:0032515
name: negative regulation of phosphoprotein phosphatase activity
namespace: biological_process
def: "Any process that stops or reduces the activity of a phosphoprotein phosphatase." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation of phosphoprotein phosphatase activity" EXACT []
synonym: "down-regulation of phosphoprotein phosphatase activity" EXACT []
synonym: "downregulation of phosphoprotein phosphatase activity" EXACT []
synonym: "inhibition of phosphoprotein phosphatase activity" NARROW []
is_a: GO:0010923 ! negative regulation of phosphatase activity
is_a: GO:0043666 ! regulation of phosphoprotein phosphatase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004721 ! phosphoprotein phosphatase activity
relationship: negatively_regulates GO:0004721 ! phosphoprotein phosphatase activity

[Term]
id: GO:0032516
name: positive regulation of phosphoprotein phosphatase activity
namespace: biological_process
def: "Any process that activates or increases the activity of a phosphoprotein phosphatase." [GOC:mah]
subset: gosubset_prok
synonym: "activation of phosphoprotein phosphatase activity" NARROW []
synonym: "stimulation of phosphoprotein phosphatase activity" NARROW []
synonym: "up regulation of phosphoprotein phosphatase activity" EXACT []
synonym: "up-regulation of phosphoprotein phosphatase activity" EXACT []
synonym: "upregulation of phosphoprotein phosphatase activity" EXACT []
is_a: GO:0010922 ! positive regulation of phosphatase activity
is_a: GO:0043666 ! regulation of phosphoprotein phosphatase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004721 ! phosphoprotein phosphatase activity
relationship: positively_regulates GO:0004721 ! phosphoprotein phosphatase activity

[Term]
id: GO:0032517
name: SOD1-calcineurin complex
namespace: cellular_component
def: "A protein complex formed by the association of superoxide dismutase 1 (SOD1) with calcineurin; complex formation is implicated in activation of calcineurin by SOD1." [GOC:mah, PMID:17324120]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0032518
name: amino acid-exporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + amino acid(in) -> ADP + phosphate + amino acid(out)." [GOC:mah]
is_a: GO:0015424 ! amino acid-transporting ATPase activity

[Term]
id: GO:0032519
name: cysteine-exporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cysteine(in) -> ADP + phosphate + cysteine(out)." [GOC:mah]
synonym: "cysteine exporter" RELATED []
is_a: GO:0032518 ! amino acid-exporting ATPase activity
is_a: GO:0033230 ! cysteine-transporting ATPase activity
relationship: part_of GO:0033228 ! cysteine export

[Term]
id: GO:0032520
name: amino acid-importing ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + amino acid(out) -> ADP + phosphate + amino acid(in)." [GOC:mah]
is_a: GO:0015424 ! amino acid-transporting ATPase activity

[Term]
id: GO:0032521
name: D-methionine-exporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-methionine(in) -> ADP + phosphate + D-methionine(out)." [GOC:mah]
synonym: "D-methionine exporter" RELATED []
is_a: GO:0032518 ! amino acid-exporting ATPase activity
is_a: GO:0033232 ! D-methionine-transporting ATPase activity

[Term]
id: GO:0032522
name: D-methionine-importing ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-methionine(out) -> ADP + phosphate + D-methionine(in)." [GOC:mah]
synonym: "D-methionine importer" RELATED []
is_a: GO:0032520 ! amino acid-importing ATPase activity
is_a: GO:0033232 ! D-methionine-transporting ATPase activity

[Term]
id: GO:0032523
name: silicon efflux transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of silicon from the inside of the cell to the outside of the cell across a membrane." [GOC:mah, PMID:17625566]
synonym: "silicon efflux transporter activity" EXACT []
is_a: GO:0008324 ! cation transmembrane transporter activity
is_a: GO:0015562 ! efflux transmembrane transporter activity

[Term]
id: GO:0032524
name: obsolete nutrient export
namespace: biological_process
def: "OBSOLETE. The directed movement of nutrients out of a cell or organelle." [GOC:mah]
comment: This term was made obsolete because "nutrient" is not defined, and does not have a consistent meaning.
subset: gosubset_prok
synonym: "nutrient export" EXACT []
is_obsolete: true
consider: GO:0006810

[Term]
id: GO:0032525
name: somite rostral/caudal axis specification
namespace: biological_process
def: "The establishment, maintenance and elaboration of the rostro-caudal axis of a somite, prior to the morphological formation of a somite boundary." [GOC:bf, PMID:16326386, PMID:17360776]
synonym: "somite rostrocaudal axis specification" EXACT []
synonym: "somite rostrocaudal polarity" RELATED []
is_a: GO:0000578 ! embryonic axis specification
is_a: GO:0009948 ! anterior/posterior axis specification
relationship: part_of GO:0001756 ! somitogenesis

[Term]
id: GO:0032526
name: response to retinoic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus." [GOC:sl]
synonym: "response to vitamin A acid" EXACT []
is_a: GO:0001101 ! response to acid chemical
is_a: GO:0033993 ! response to lipid
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0032527
name: protein exit from endoplasmic reticulum
namespace: biological_process
def: "The directed movement of proteins from the endoplasmic reticulum." [GOC:rb]
synonym: "protein exit from ER" EXACT []
synonym: "protein export from endoplasmic reticulum" EXACT [GOC:mah]
synonym: "protein export from ER" EXACT [GOC:mah]
is_a: GO:0006886 ! intracellular protein transport
is_a: GO:1902582 ! single-organism intracellular transport
relationship: occurs_in GO:0005737 ! cytoplasm

[Term]
id: GO:0032528
name: microvillus organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell." [GOC:mah]
synonym: "microvillus organisation" EXACT [GOC:mah]
synonym: "microvillus organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0030030 ! cell projection organization

[Term]
id: GO:0032529
name: follicle cell microvillus organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microvillus on a follicle cell. A microvillus is a thin cylindrical membrane-covered projection on the surface of an animal cell containing a core bundle of actin filaments." [GOC:sart, PMID:16507588]
synonym: "follicle cell microvillus organisation" EXACT [GOC:mah]
synonym: "follicle cell microvillus organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0032528 ! microvillus organization

[Term]
id: GO:0032530
name: regulation of microvillus organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a microvillus." [GOC:mah]
synonym: "regulation of microvillus organisation" EXACT [GOC:mah]
synonym: "regulation of microvillus organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0031344 ! regulation of cell projection organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032528 ! microvillus organization
relationship: regulates GO:0032528 ! microvillus organization

[Term]
id: GO:0032531
name: regulation of follicle cell microvillus organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a microvillus on a follicle cell." [GOC:mah]
synonym: "regulation of follicle cell microvillus organisation" EXACT [GOC:mah]
synonym: "regulation of follicle cell microvillus organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0032530 ! regulation of microvillus organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032529 ! follicle cell microvillus organization
relationship: regulates GO:0032529 ! follicle cell microvillus organization

[Term]
id: GO:0032532
name: regulation of microvillus length
namespace: biological_process
def: "A process that modulates the length of a microvillus." [GOC:mah]
is_a: GO:0032530 ! regulation of microvillus organization
is_a: GO:0032536 ! regulation of cell projection size

[Term]
id: GO:0032533
name: regulation of follicle cell microvillus length
namespace: biological_process
def: "A process that modulates the length of a microvillus on a follicle cell." [GOC:sart, PMID:16260500]
is_a: GO:0032531 ! regulation of follicle cell microvillus organization
is_a: GO:0032532 ! regulation of microvillus length

[Term]
id: GO:0032534
name: regulation of microvillus assembly
namespace: biological_process
def: "A process that modulates the formation of a microvillus." [GOC:mah]
synonym: "regulation of microvillus biogenesis" RELATED [GOC:mah]
is_a: GO:0032530 ! regulation of microvillus organization
is_a: GO:0060491 ! regulation of cell projection assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030033 ! microvillus assembly
relationship: regulates GO:0030033 ! microvillus assembly

[Term]
id: GO:0032535
name: regulation of cellular component size
namespace: biological_process
def: "A process that modulates the size of a cellular component." [GOC:mah]
subset: gosubset_prok
is_a: GO:0016043 ! cellular component organization
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0090066 ! regulation of anatomical structure size

[Term]
id: GO:0032536
name: regulation of cell projection size
namespace: biological_process
def: "A process that modulates the size of a cell projection." [GOC:mah]
is_a: GO:0032535 ! regulation of cellular component size

[Term]
id: GO:0032537
name: host-seeking behavior
namespace: biological_process
def: "The specific behavior of an organism that are associated with finding a host organism; may include behavioral responses to light, temperature, or chemical emanations from the prospective host." [GOC:mah, GOC:pr, PMID:11931033]
synonym: "host-seeking behaviour" EXACT []
is_a: GO:0044708 ! single-organism behavior

[Term]
id: GO:0032538
name: regulation of host-seeking behavior
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of any behavior associated with finding a host organism." [GOC:mah]
synonym: "regulation of host-seeking behaviour" EXACT []
is_a: GO:0050795 ! regulation of behavior
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032537 ! host-seeking behavior
relationship: regulates GO:0032537 ! host-seeking behavior

[Term]
id: GO:0032539
name: negative regulation of host-seeking behavior
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of any behavior associated with finding a host organism." [GOC:mah]
synonym: "down regulation of host-seeking behavior" EXACT []
synonym: "down-regulation of host-seeking behavior" EXACT []
synonym: "downregulation of host-seeking behavior" EXACT []
synonym: "inhibition of host-seeking behavior" NARROW []
synonym: "negative regulation of host-seeking behaviour" EXACT []
is_a: GO:0032538 ! regulation of host-seeking behavior
is_a: GO:0048521 ! negative regulation of behavior
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032537 ! host-seeking behavior
relationship: negatively_regulates GO:0032537 ! host-seeking behavior

[Term]
id: GO:0032540
name: positive regulation of host-seeking behavior
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of any behavior associated with finding a host organism." [GOC:mah]
synonym: "activation of host-seeking behavior" NARROW []
synonym: "positive regulation of host-seeking behaviour" EXACT []
synonym: "stimulation of host-seeking behavior" NARROW []
synonym: "up regulation of host-seeking behavior" EXACT []
synonym: "up-regulation of host-seeking behavior" EXACT []
synonym: "upregulation of host-seeking behavior" EXACT []
is_a: GO:0032538 ! regulation of host-seeking behavior
is_a: GO:0048520 ! positive regulation of behavior
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032537 ! host-seeking behavior
relationship: positively_regulates GO:0032537 ! host-seeking behavior

[Term]
id: GO:0032541
name: cortical endoplasmic reticulum
namespace: cellular_component
def: "A cortical network of highly dynamic tubules that are juxtaposed to the plasma membrane and undergo ring closure and tubule-branching movements." [GOC:se, PMID:10931860, PMID:17686782]
synonym: "cortical ER" EXACT []
synonym: "ER-PM peripheral junction" BROAD [GOC:ans, PMID:21062895]
synonym: "peripheral endoplasmic reticulum" RELATED []
synonym: "peripheral ER" RELATED []
is_a: GO:0044448 ! cell cortex part
is_a: GO:0071782 ! endoplasmic reticulum tubular network
intersection_of: GO:0071782 ! endoplasmic reticulum tubular network
intersection_of: part_of GO:0005938 ! cell cortex
relationship: part_of GO:0005938 ! cell cortex

[Term]
id: GO:0032542
name: sulfiredoxin activity
namespace: molecular_function
def: "Catalysis of the reaction: peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R." [EC:1.8.98.2, PMID:16102934]
synonym: "peroxiredoxin-(S-hydroxy-S-oxocysteine) reductase activity" EXACT []
synonym: "peroxiredoxin-(S-hydroxy-S-oxocysteine):thiol oxidoreductase [ATP-hydrolysing; peroxiredoxin-(S-hydroxycysteine)-forming]" RELATED [EC:1.8.98.2]
synonym: "Srx1" RELATED [EC:1.8.98.2]
synonym: "sulphiredoxin activity" EXACT []
xref: EC:1.8.98.2
xref: MetaCyc:1.8.98.2-RXN
is_a: GO:0016209 ! antioxidant activity
is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors

[Term]
id: GO:0032543
name: mitochondrial translation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators]
subset: goslim_yeast
synonym: "mitochondrial protein anabolism" EXACT []
synonym: "mitochondrial protein biosynthesis" EXACT []
synonym: "mitochondrial protein formation" EXACT []
synonym: "mitochondrial protein synthesis" EXACT []
synonym: "mitochondrial protein translation" EXACT []
is_a: GO:0006412 ! translation
is_a: GO:0007005 ! mitochondrion organization
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:1902589 ! single-organism organelle organization
intersection_of: GO:0006412 ! translation
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion

[Term]
id: GO:0032544
name: plastid translation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a protein in a plastid. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the plastid has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators]
synonym: "plastid protein anabolism" EXACT []
synonym: "plastid protein biosynthesis" EXACT []
synonym: "plastid protein formation" EXACT []
synonym: "plastid protein synthesis" EXACT []
synonym: "plastid protein translation" EXACT []
is_a: GO:0006412 ! translation
is_a: GO:0009657 ! plastid organization
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:1902589 ! single-organism organelle organization
intersection_of: GO:0006412 ! translation
intersection_of: occurs_in GO:0009536 ! plastid
relationship: occurs_in GO:0009536 ! plastid

[Term]
id: GO:0032545
name: CURI complex
namespace: cellular_component
def: "A protein complex that is involved in the transcription of ribosomal genes. In Saccharomyces this complex consists of Ckb2p, Utp22p, Rrp7p and Ifh1p." [PMID:17452446]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0032546
name: deoxyribonucleoside binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a deoxyribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to deoxyribose." [GOC:mah]
subset: gosubset_prok
is_a: GO:0001882 ! nucleoside binding

[Term]
id: GO:0032547
name: purine deoxyribonucleoside binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a purine deoxyribonucleoside, a compound consisting of a purine base linked to deoxyribose." [GOC:mah]
subset: gosubset_prok
is_a: GO:0001883 ! purine nucleoside binding
is_a: GO:0032546 ! deoxyribonucleoside binding

[Term]
id: GO:0032548
name: pyrimidine deoxyribonucleoside binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a pyrimidine deoxyribonucleoside, a compound consisting of a pyrimidine base linked to deoxyribose." [GOC:mah]
subset: gosubset_prok
is_a: GO:0001884 ! pyrimidine nucleoside binding
is_a: GO:0032546 ! deoxyribonucleoside binding

[Term]
id: GO:0032549
name: ribonucleoside binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose." [GOC:mah]
subset: gosubset_prok
is_a: GO:0001882 ! nucleoside binding

[Term]
id: GO:0032550
name: purine ribonucleoside binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a purine ribonucleoside, a compound consisting of a purine base linked to ribose." [GOC:mah]
subset: gosubset_prok
is_a: GO:0001883 ! purine nucleoside binding
is_a: GO:0032549 ! ribonucleoside binding

[Term]
id: GO:0032551
name: pyrimidine ribonucleoside binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a pyrimidine ribonucleoside, a compound consisting of a pyrimidine base linked to ribose." [GOC:mah]
subset: gosubset_prok
is_a: GO:0001884 ! pyrimidine nucleoside binding
is_a: GO:0032549 ! ribonucleoside binding

[Term]
id: GO:0032552
name: deoxyribonucleotide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a deoxyribonucleotide, any compound consisting of a deoxyribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety." [GOC:mah]
subset: gosubset_prok
is_a: GO:0000166 ! nucleotide binding
is_a: GO:0097367 ! carbohydrate derivative binding

[Term]
id: GO:0032553
name: ribonucleotide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah]
subset: gosubset_prok
is_a: GO:0000166 ! nucleotide binding
is_a: GO:0097367 ! carbohydrate derivative binding

[Term]
id: GO:0032554
name: purine deoxyribonucleotide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a purine deoxyribonucleotide, any compound consisting of a purine deoxyribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety." [GOC:mah]
subset: gosubset_prok
is_a: GO:0017076 ! purine nucleotide binding
is_a: GO:0032552 ! deoxyribonucleotide binding

[Term]
id: GO:0032555
name: purine ribonucleotide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah]
subset: gosubset_prok
is_a: GO:0017076 ! purine nucleotide binding
is_a: GO:0032553 ! ribonucleotide binding

[Term]
id: GO:0032556
name: pyrimidine deoxyribonucleotide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a pyrimidine deoxyribonucleotide, any compound consisting of a pyrimidine deoxyribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety." [GOC:mah]
subset: gosubset_prok
is_a: GO:0019103 ! pyrimidine nucleotide binding
is_a: GO:0032552 ! deoxyribonucleotide binding

[Term]
id: GO:0032557
name: pyrimidine ribonucleotide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a pyrimidine ribonucleotide, any compound consisting of a pyrimidine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah]
subset: gosubset_prok
is_a: GO:0019103 ! pyrimidine nucleotide binding
is_a: GO:0032553 ! ribonucleotide binding

[Term]
id: GO:0032558
name: adenyl deoxyribonucleotide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an adenyl deoxyribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety." [GOC:mah]
subset: gosubset_prok
is_a: GO:0030554 ! adenyl nucleotide binding
is_a: GO:0032554 ! purine deoxyribonucleotide binding

[Term]
id: GO:0032559
name: adenyl ribonucleotide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah]
subset: gosubset_prok
is_a: GO:0030554 ! adenyl nucleotide binding
is_a: GO:0032555 ! purine ribonucleotide binding

[Term]
id: GO:0032560
name: guanyl deoxyribonucleotide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a guanyl deoxyribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety." [GOC:mah]
subset: gosubset_prok
is_a: GO:0019001 ! guanyl nucleotide binding
is_a: GO:0032554 ! purine deoxyribonucleotide binding
is_a: GO:0043168 ! anion binding

[Term]
id: GO:0032561
name: guanyl ribonucleotide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a guanyl ribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah]
subset: gosubset_prok
is_a: GO:0019001 ! guanyl nucleotide binding
is_a: GO:0032555 ! purine ribonucleotide binding

[Term]
id: GO:0032562
name: dAMP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with dAMP, deoxyadenosine monophosphate." [GOC:mah]
is_a: GO:0032558 ! adenyl deoxyribonucleotide binding
is_a: GO:0043168 ! anion binding

[Term]
id: GO:0032563
name: dADP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with dADP, deoxyadenosine diphosphate." [GOC:mah]
is_a: GO:0032558 ! adenyl deoxyribonucleotide binding
is_a: GO:0043168 ! anion binding

[Term]
id: GO:0032564
name: dATP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with dATP, deoxyadenosine triphosphate." [GOC:mah]
is_a: GO:0032558 ! adenyl deoxyribonucleotide binding
is_a: GO:0043168 ! anion binding

[Term]
id: GO:0032565
name: dGMP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with dGMP, deoxyguanosine monophosphate." [GOC:mah]
is_a: GO:0032560 ! guanyl deoxyribonucleotide binding

[Term]
id: GO:0032566
name: dGDP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with dGDP, deoxyguanosine diphosphate." [GOC:mah]
is_a: GO:0032560 ! guanyl deoxyribonucleotide binding

[Term]
id: GO:0032567
name: dGTP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with dGTP, deoxyguanosine triphosphate." [GOC:mah]
is_a: GO:0032560 ! guanyl deoxyribonucleotide binding

[Term]
id: GO:0032570
name: response to progesterone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus." [GOC:sl]
synonym: "response to progesterone stimulus" EXACT [GOC:dos]
is_a: GO:0048545 ! response to steroid hormone
is_a: GO:1901654 ! response to ketone

[Term]
id: GO:0032571
name: response to vitamin K
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin K stimulus." [GOC:sl]
is_a: GO:0033273 ! response to vitamin
is_a: GO:1901654 ! response to ketone

[Term]
id: GO:0032572
name: response to menaquinone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a menaquinone (vitamin K2) stimulus." [GOC:sl]
synonym: "response to menatetrenone" EXACT []
synonym: "response to vitamin K2" EXACT []
is_a: GO:1901654 ! response to ketone

[Term]
id: GO:0032573
name: response to phylloquinone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phylloquinone (vitamin K1) stimulus." [GOC:sl]
synonym: "response to vitamin K1" EXACT []
is_a: GO:1901654 ! response to ketone

[Term]
id: GO:0032574
name: 5'-3' RNA helicase activity
namespace: molecular_function
def: "Catalysis of the unwinding of an RNA helix in the direction 5' to 3'." [GOC:jp]
synonym: "5' to 3' RNA helicase activity" EXACT []
is_a: GO:0003724 ! RNA helicase activity

[Term]
id: GO:0032575
name: ATP-dependent 5'-3' RNA helicase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix in the direction 5' to 3'." [GOC:jp]
synonym: "ATP-dependent 5' to 3' RNA helicase activity" EXACT []
is_a: GO:0004004 ! ATP-dependent RNA helicase activity
is_a: GO:0032574 ! 5'-3' RNA helicase activity

[Term]
id: GO:0032576
name: O-linoleoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a linoleoyl ((9Z,12Z)-octadeca-9,12-dienoyl) group to an oxygen atom on the acceptor molecule." [GOC:cb]
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0032577
name: phosphatidylcholine:cardiolipin O-linoleoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a linoleoyl ((9Z,12Z)-octadeca-9,12-dienoyl) group from phosphatidylcholine to an oxygen atom on a cardiolipin molecule." [GOC:cb, GOC:mah]
synonym: "phosphatidylcholine:cardiolipin linoleoyltransferase" EXACT []
is_a: GO:0032576 ! O-linoleoyltransferase activity

[Term]
id: GO:0032578
name: aleurone grain membrane
namespace: cellular_component
def: "The lipid bilayer surrounding an aleurone grain." [GOC:ecd]
is_a: GO:0030659 ! cytoplasmic vesicle membrane
is_a: GO:0098588 ! bounding membrane of organelle
is_a: GO:0098805 ! whole membrane
relationship: part_of GO:0033095 ! aleurone grain

[Term]
id: GO:0032579
name: apical lamina of hyaline layer
namespace: cellular_component
def: "A fibrous network that is part of the hyalin layer extracellular matrix. The apical lamina is thought to be principally composed of the glycoproteins fibropellins. This matrix has been found in echinoderms." [GOC:ecd, PMID:2060714, PMID:7608987, PMID:9638331]
is_a: GO:0044420 ! extracellular matrix component
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0033166 ! hyaline layer

[Term]
id: GO:0032580
name: Golgi cisterna membrane
namespace: cellular_component
def: "The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex." [GOC:ecd, GOC:mah]
synonym: "Golgi stack membrane" EXACT []
is_a: GO:0000139 ! Golgi membrane
relationship: part_of GO:0031985 ! Golgi cisterna

[Term]
id: GO:0032581
name: ER-dependent peroxisome organization
namespace: biological_process
def: "A process of peroxisome organization in which assembly or arrangement of constituent parts takes place in the endoplasmic reticulum." [GOC:mah, PMID:16717127, PMID:17646399]
synonym: "endoplasmic reticulum-dependent peroxisome organization" EXACT [GOC:mah]
synonym: "ER-dependent peroxisome biogenesis" RELATED [GOC:mah]
synonym: "ER-dependent peroxisome organisation" EXACT [GOC:mah]
is_a: GO:0007031 ! peroxisome organization

[Term]
id: GO:0032584
name: growth cone membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a growth cone." [GOC:mah]
is_a: GO:0044459 ! plasma membrane part
is_a: GO:0044463 ! cell projection part
is_a: GO:0097458 ! neuron part
relationship: part_of GO:0030426 ! growth cone

[Term]
id: GO:0032585
name: multivesicular body membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a multivesicular body." [GOC:mah]
synonym: "multivesicular endosome membrane" EXACT []
synonym: "MVB membrane" EXACT []
synonym: "MVE membrane" EXACT []
is_a: GO:0031902 ! late endosome membrane
relationship: part_of GO:0005771 ! multivesicular body

[Term]
id: GO:0032586
name: protein storage vacuole membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a protein storage vacuole." [GOC:mah]
is_a: GO:0009705 ! plant-type vacuole membrane

[Term]
id: GO:0032587
name: ruffle membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a ruffle." [GOC:mah]
synonym: "membrane ruffle" RELATED []
is_a: GO:0031253 ! cell projection membrane
is_a: GO:0031256 ! leading edge membrane
relationship: part_of GO:0001726 ! ruffle

[Term]
id: GO:0032588
name: trans-Golgi network membrane
namespace: cellular_component
def: "The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network." [GOC:mah]
synonym: "Golgi trans face membrane" RELATED []
synonym: "trans Golgi network membrane" EXACT []
is_a: GO:0000139 ! Golgi membrane
relationship: part_of GO:0005802 ! trans-Golgi network

[Term]
id: GO:0032589
name: neuron projection membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a neuron projection." [GOC:mah]
is_a: GO:0031253 ! cell projection membrane
is_a: GO:0031256 ! leading edge membrane
is_a: GO:0097458 ! neuron part
relationship: part_of GO:0043005 ! neuron projection

[Term]
id: GO:0032590
name: dendrite membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a dendrite." [GOC:mah]
is_a: GO:0032589 ! neuron projection membrane

[Term]
id: GO:0032591
name: dendritic spine membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a dendritic spine." [GOC:mah]
is_a: GO:0032589 ! neuron projection membrane
is_a: GO:0097060 ! synaptic membrane
relationship: part_of GO:0032590 ! dendrite membrane

[Term]
id: GO:0032592
name: integral component of mitochondrial membrane
namespace: cellular_component
def: "The component of the mitochondrial membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]
synonym: "integral to mitochondrial membrane" NARROW []
is_a: GO:0031301 ! integral component of organelle membrane
is_a: GO:0098573 ! intrinsic component of mitochondrial membrane
intersection_of: GO:0016021 ! integral component of membrane
intersection_of: part_of GO:0031966 ! mitochondrial membrane
relationship: part_of GO:0031966 ! mitochondrial membrane

[Term]
id: GO:0032593
name: insulin-responsive compartment
namespace: cellular_component
def: "A small membrane-bounded vesicle that releases its contents by exocytosis in response to insulin stimulation; the contents are enriched in GLUT4, IRAP and VAMP2." [PMID:17644329]
synonym: "GLUT4 storage compartment" EXACT []
synonym: "GSC" RELATED []
synonym: "IRC" RELATED []
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0032594
name: protein transport within lipid bilayer
namespace: biological_process
def: "The directed movement of a protein from one location to another within a lipid bilayer." [GOC:mah]
synonym: "protein translocation within membrane" EXACT []
synonym: "receptor translocation within membrane" NARROW []
synonym: "receptor transport within lipid bilayer" NARROW []
is_a: GO:0006886 ! intracellular protein transport
is_a: GO:0044802 ! single-organism membrane organization
is_a: GO:0051668 ! localization within membrane
is_a: GO:1902580 ! single-organism cellular localization
is_a: GO:1902582 ! single-organism intracellular transport
intersection_of: GO:0015031 ! protein transport
intersection_of: occurs_in GO:0016020 ! membrane
relationship: occurs_in GO:0016020 ! membrane

[Term]
id: GO:0032595
name: B cell receptor transport within lipid bilayer
namespace: biological_process
def: "The directed movement of a B cell receptor within a lipid bilayer." [GOC:mah]
synonym: "B cell receptor translocation within membrane" EXACT []
synonym: "BCR translocation within membrane" EXACT []
synonym: "BCR transport within lipid bilayer" EXACT []
is_a: GO:0032594 ! protein transport within lipid bilayer

[Term]
id: GO:0032596
name: protein transport into membrane raft
namespace: biological_process
def: "The directed movement of a protein into a membrane raft. Membrane rafts are small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes." [GOC:mah]
synonym: "protein translocation into membrane raft" EXACT []
synonym: "protein transport into lipid raft" EXACT []
synonym: "receptor translocation into membrane raft" NARROW []
synonym: "receptor transport into membrane raft" NARROW []
is_a: GO:0032594 ! protein transport within lipid bilayer
is_a: GO:0090150 ! establishment of protein localization to membrane
is_a: GO:1903044 ! protein localization to membrane raft

[Term]
id: GO:0032597
name: B cell receptor transport into membrane raft
namespace: biological_process
def: "The directed movement of a B cell receptor into a membrane raft." [GOC:mah]
synonym: "B cell receptor translocation into membrane raft" EXACT []
synonym: "B cell receptor transport into lipid raft" EXACT []
synonym: "BCR translocation into membrane raft" EXACT []
synonym: "BCR transport into membrane raft" EXACT []
is_a: GO:0032595 ! B cell receptor transport within lipid bilayer
is_a: GO:0032596 ! protein transport into membrane raft

[Term]
id: GO:0032598
name: B cell receptor transport into immunological synapse
namespace: biological_process
def: "The directed movement of a B cell receptor into an immunological synapse." [GOC:mah]
synonym: "B cell receptor translocation into immunological synapse" EXACT []
synonym: "BCR translocation into immunological synapse" EXACT []
synonym: "BCR transport into immunological synapse" EXACT []
is_a: GO:0032597 ! B cell receptor transport into membrane raft

[Term]
id: GO:0032599
name: protein transport out of membrane raft
namespace: biological_process
def: "The directed movement of a protein out of a membrane raft. Membrane rafts are small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes." [GOC:mah]
synonym: "protein translocation out of membrane raft" EXACT []
synonym: "protein transport out of lipid raft" EXACT []
synonym: "receptor translocation out of membrane raft" NARROW []
synonym: "receptor transport out of membrane raft" NARROW []
is_a: GO:0032594 ! protein transport within lipid bilayer

[Term]
id: GO:0032600
name: chemokine receptor transport out of membrane raft
namespace: biological_process
def: "The directed movement of a chemokine receptor out of a membrane raft." [GOC:mah]
synonym: "chemokine receptor translocation out of membrane raft" EXACT []
synonym: "chemokine receptor transport out of lipid raft" EXACT []
is_a: GO:0032599 ! protein transport out of membrane raft
is_a: GO:0033606 ! chemokine receptor transport within lipid bilayer

[Term]
id: GO:0032601
name: connective tissue growth factor production
namespace: biological_process
def: "The appearance of connective tissue growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "CCN2 production" EXACT []
synonym: "CTGF production" EXACT []
synonym: "Fisp12 production" EXACT []
synonym: "Hcs24 production" EXACT []
synonym: "hypertrophic chondrocyte-specific gene product 24 production" EXACT []
synonym: "IGFBP8 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032602
name: chemokine production
namespace: biological_process
def: "The appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032603
name: fractalkine production
namespace: biological_process
def: "The appearance of fractalkine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
is_a: GO:0032602 ! chemokine production

[Term]
id: GO:0032604
name: granulocyte macrophage colony-stimulating factor production
namespace: biological_process
def: "The appearance of granulocyte macrophage colony-stimulating factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "GM-CSF production" EXACT [GOC:vk]
synonym: "granulocyte macrophage colony stimulating factor production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032605
name: hepatocyte growth factor production
namespace: biological_process
def: "The appearance of hepatocyte growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032606
name: type I interferon production
namespace: biological_process
def: "The appearance of type I interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16681834]
synonym: "interferon type I production" EXACT []
synonym: "type I IFN production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032607
name: interferon-alpha production
namespace: biological_process
def: "The appearance of interferon-alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IFN-alpha production" EXACT [GOC:mah]
synonym: "IFNA production" EXACT [GOC:mah]
is_a: GO:0032606 ! type I interferon production

[Term]
id: GO:0032608
name: interferon-beta production
namespace: biological_process
def: "The appearance of interferon-beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IFN-beta production" EXACT []
synonym: "IFNB production" EXACT [GOC:mah]
is_a: GO:0032606 ! type I interferon production

[Term]
id: GO:0032609
name: interferon-gamma production
namespace: biological_process
def: "The appearance of interferon-gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:mah]
synonym: "IFNG production" EXACT [GOC:mah]
synonym: "type II IFN production" BROAD [GOC:mah]
synonym: "type II interferon production" BROAD []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032610
name: interleukin-1 alpha production
namespace: biological_process
def: "The appearance of interleukin-1 alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-1 alpha production" EXACT []
is_a: GO:0032612 ! interleukin-1 production

[Term]
id: GO:0032611
name: interleukin-1 beta production
namespace: biological_process
def: "The appearance of interleukin-1 beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-1 beta production" EXACT []
is_a: GO:0032612 ! interleukin-1 production

[Term]
id: GO:0032612
name: interleukin-1 production
namespace: biological_process
def: "The appearance of interleukin-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-1 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032613
name: interleukin-10 production
namespace: biological_process
def: "The appearance of interleukin-10 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-10 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032614
name: interleukin-11 production
namespace: biological_process
def: "The appearance of interleukin-11 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-11 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032615
name: interleukin-12 production
namespace: biological_process
def: "The appearance of interleukin-12 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-12 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032616
name: interleukin-13 production
namespace: biological_process
def: "The appearance of interleukin-13 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-13 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032617
name: interleukin-14 production
namespace: biological_process
def: "The appearance of interleukin-14 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-14 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032618
name: interleukin-15 production
namespace: biological_process
def: "The appearance of interleukin-15 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-15 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032619
name: interleukin-16 production
namespace: biological_process
def: "The appearance of interleukin-16 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-16 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032620
name: interleukin-17 production
namespace: biological_process
def: "The appearance of any member of the interleukin-17 family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah, GOC:rv, PR:000001092, Wikipedia:Interleukin_17]
synonym: "IL-17 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032621
name: interleukin-18 production
namespace: biological_process
def: "The appearance of interleukin-18 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-18 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032622
name: interleukin-19 production
namespace: biological_process
def: "The appearance of interleukin-19 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-19 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032623
name: interleukin-2 production
namespace: biological_process
def: "The appearance of interleukin-2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-2 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032624
name: interleukin-20 production
namespace: biological_process
def: "The appearance of interleukin-20 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-20 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032625
name: interleukin-21 production
namespace: biological_process
def: "The appearance of interleukin-21 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-21 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032626
name: interleukin-22 production
namespace: biological_process
def: "The appearance of interleukin-22 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-22 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032627
name: interleukin-23 production
namespace: biological_process
def: "The appearance of interleukin-23 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-23 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032628
name: interleukin-24 production
namespace: biological_process
def: "The appearance of interleukin-24 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-24 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032629
name: interleukin-25 production
namespace: biological_process
def: "The appearance of interleukin-25 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-25 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032630
name: interleukin-26 production
namespace: biological_process
def: "The appearance of interleukin-26 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-26 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032631
name: interleukin-27 production
namespace: biological_process
def: "The appearance of interleukin-27 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-27 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032632
name: interleukin-3 production
namespace: biological_process
def: "The appearance of interleukin-3 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-3 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032633
name: interleukin-4 production
namespace: biological_process
def: "The appearance of interleukin-4 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-4 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032634
name: interleukin-5 production
namespace: biological_process
def: "The appearance of interleukin-5 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-5 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032635
name: interleukin-6 production
namespace: biological_process
def: "The appearance of interleukin-6 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-6 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032636
name: interleukin-7 production
namespace: biological_process
def: "The appearance of interleukin-7 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-7 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032637
name: interleukin-8 production
namespace: biological_process
def: "The appearance of interleukin-8 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-8 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032638
name: interleukin-9 production
namespace: biological_process
def: "The appearance of interleukin-9 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-9 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032639
name: TRAIL production
namespace: biological_process
def: "The appearance of TRAIL due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
is_a: GO:0071706 ! tumor necrosis factor superfamily cytokine production

[Term]
id: GO:0032640
name: tumor necrosis factor production
namespace: biological_process
def: "The appearance of tumor necrosis factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF').
synonym: "TNF production" EXACT []
synonym: "TNF-alpha production" EXACT []
synonym: "tumor necrosis factor-alpha production" EXACT []
is_a: GO:0071706 ! tumor necrosis factor superfamily cytokine production

[Term]
id: GO:0032641
name: lymphotoxin A production
namespace: biological_process
def: "The appearance of lymphotoxin A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "LTA production" EXACT []
synonym: "lymphotoxin-alpha production" EXACT []
synonym: "TNF-beta production" EXACT []
synonym: "tumor necrosis factor-beta production" EXACT []
is_a: GO:0071706 ! tumor necrosis factor superfamily cytokine production

[Term]
id: GO:0032642
name: regulation of chemokine production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of chemokine production." [GOC:mah]
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032602 ! chemokine production
relationship: regulates GO:0032602 ! chemokine production

[Term]
id: GO:0032643
name: regulation of connective tissue growth factor production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of connective tissue growth factor production." [GOC:mah]
synonym: "regulation of CCN2 production" EXACT []
synonym: "regulation of CTGF production" EXACT []
synonym: "regulation of Fisp12 production" EXACT []
synonym: "regulation of Hcs24 production" EXACT []
synonym: "regulation of hypertrophic chondrocyte-specific gene product 24 production" EXACT []
synonym: "regulation of IGFBP8 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032601 ! connective tissue growth factor production
relationship: regulates GO:0032601 ! connective tissue growth factor production

[Term]
id: GO:0032644
name: regulation of fractalkine production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of fractalkine production." [GOC:mah]
is_a: GO:0032642 ! regulation of chemokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032603 ! fractalkine production
relationship: regulates GO:0032603 ! fractalkine production

[Term]
id: GO:0032645
name: regulation of granulocyte macrophage colony-stimulating factor production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production." [GOC:mah]
synonym: "regulation of GM-CSF production" EXACT [GOC:vk]
synonym: "regulation of granulocyte macrophage colony stimulating factor production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032604 ! granulocyte macrophage colony-stimulating factor production
relationship: regulates GO:0032604 ! granulocyte macrophage colony-stimulating factor production

[Term]
id: GO:0032646
name: regulation of hepatocyte growth factor production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of hepatocyte growth factor production." [GOC:mah]
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032605 ! hepatocyte growth factor production
relationship: regulates GO:0032605 ! hepatocyte growth factor production

[Term]
id: GO:0032647
name: regulation of interferon-alpha production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interferon-alpha production." [GOC:mah]
is_a: GO:0032479 ! regulation of type I interferon production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032607 ! interferon-alpha production
relationship: regulates GO:0032607 ! interferon-alpha production

[Term]
id: GO:0032648
name: regulation of interferon-beta production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interferon-beta production." [GOC:mah]
synonym: "regulation of IFN-beta production" EXACT []
is_a: GO:0032479 ! regulation of type I interferon production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032608 ! interferon-beta production
relationship: regulates GO:0032608 ! interferon-beta production

[Term]
id: GO:0032649
name: regulation of interferon-gamma production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:mah]
synonym: "regulation of type II interferon production" BROAD []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032609 ! interferon-gamma production
relationship: regulates GO:0032609 ! interferon-gamma production

[Term]
id: GO:0032650
name: regulation of interleukin-1 alpha production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-1 alpha production." [GOC:mah]
synonym: "regulation of IL-1 alpha production" EXACT []
is_a: GO:0032652 ! regulation of interleukin-1 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032610 ! interleukin-1 alpha production
relationship: regulates GO:0032610 ! interleukin-1 alpha production

[Term]
id: GO:0032651
name: regulation of interleukin-1 beta production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-1 beta production." [GOC:mah]
synonym: "regulation of IL-1 beta production" EXACT []
is_a: GO:0032652 ! regulation of interleukin-1 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032611 ! interleukin-1 beta production
relationship: regulates GO:0032611 ! interleukin-1 beta production

[Term]
id: GO:0032652
name: regulation of interleukin-1 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-1 production." [GOC:mah]
synonym: "regulation of IL-1 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032612 ! interleukin-1 production
relationship: regulates GO:0032612 ! interleukin-1 production

[Term]
id: GO:0032653
name: regulation of interleukin-10 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-10 production." [GOC:mah]
synonym: "regulation of IL-10 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032613 ! interleukin-10 production
relationship: regulates GO:0032613 ! interleukin-10 production

[Term]
id: GO:0032654
name: regulation of interleukin-11 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-11 production." [GOC:mah]
synonym: "regulation of IL-11 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032614 ! interleukin-11 production
relationship: regulates GO:0032614 ! interleukin-11 production

[Term]
id: GO:0032655
name: regulation of interleukin-12 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-12 production." [GOC:mah]
synonym: "regulation of IL-12 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032615 ! interleukin-12 production
relationship: regulates GO:0032615 ! interleukin-12 production

[Term]
id: GO:0032656
name: regulation of interleukin-13 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-13 production." [GOC:mah]
synonym: "regulation of IL-13 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032616 ! interleukin-13 production
relationship: regulates GO:0032616 ! interleukin-13 production

[Term]
id: GO:0032657
name: regulation of interleukin-14 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-14 production." [GOC:mah]
synonym: "regulation of IL-14 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032617 ! interleukin-14 production
relationship: regulates GO:0032617 ! interleukin-14 production

[Term]
id: GO:0032658
name: regulation of interleukin-15 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-15 production." [GOC:mah]
synonym: "regulation of IL-15 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032618 ! interleukin-15 production
relationship: regulates GO:0032618 ! interleukin-15 production

[Term]
id: GO:0032659
name: regulation of interleukin-16 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-16 production." [GOC:mah]
synonym: "regulation of IL-16 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032619 ! interleukin-16 production
relationship: regulates GO:0032619 ! interleukin-16 production

[Term]
id: GO:0032660
name: regulation of interleukin-17 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines." [GOC:add, GOC:mah]
synonym: "regulation of IL-17 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032620 ! interleukin-17 production
relationship: regulates GO:0032620 ! interleukin-17 production

[Term]
id: GO:0032661
name: regulation of interleukin-18 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-18 production." [GOC:mah]
synonym: "regulation of IL-18 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032621 ! interleukin-18 production
relationship: regulates GO:0032621 ! interleukin-18 production

[Term]
id: GO:0032662
name: regulation of interleukin-19 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-19 production." [GOC:mah]
synonym: "regulation of IL-19 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032622 ! interleukin-19 production
relationship: regulates GO:0032622 ! interleukin-19 production

[Term]
id: GO:0032663
name: regulation of interleukin-2 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-2 production." [GOC:mah]
synonym: "regulation of IL-2 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032623 ! interleukin-2 production
relationship: regulates GO:0032623 ! interleukin-2 production

[Term]
id: GO:0032664
name: regulation of interleukin-20 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-20 production." [GOC:mah]
synonym: "regulation of IL-20 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032624 ! interleukin-20 production
relationship: regulates GO:0032624 ! interleukin-20 production

[Term]
id: GO:0032665
name: regulation of interleukin-21 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-21 production." [GOC:mah]
synonym: "regulation of IL-21 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032625 ! interleukin-21 production
relationship: regulates GO:0032625 ! interleukin-21 production

[Term]
id: GO:0032666
name: regulation of interleukin-22 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-22 production." [GOC:mah]
synonym: "regulation of IL-22 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032626 ! interleukin-22 production
relationship: regulates GO:0032626 ! interleukin-22 production

[Term]
id: GO:0032667
name: regulation of interleukin-23 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-23 production." [GOC:mah]
synonym: "regulation of IL-23 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032627 ! interleukin-23 production
relationship: regulates GO:0032627 ! interleukin-23 production

[Term]
id: GO:0032668
name: regulation of interleukin-24 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-24 production." [GOC:mah]
synonym: "regulation of IL-24 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032628 ! interleukin-24 production
relationship: regulates GO:0032628 ! interleukin-24 production

[Term]
id: GO:0032669
name: regulation of interleukin-25 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-25 production." [GOC:mah]
synonym: "regulation of IL-25 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032629 ! interleukin-25 production
relationship: regulates GO:0032629 ! interleukin-25 production

[Term]
id: GO:0032670
name: regulation of interleukin-26 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-26 production." [GOC:mah]
synonym: "regulation of IL-26 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032630 ! interleukin-26 production
relationship: regulates GO:0032630 ! interleukin-26 production

[Term]
id: GO:0032671
name: regulation of interleukin-27 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-27 production." [GOC:mah]
synonym: "regulation of IL-27 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032631 ! interleukin-27 production
relationship: regulates GO:0032631 ! interleukin-27 production

[Term]
id: GO:0032672
name: regulation of interleukin-3 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-3 production." [GOC:mah]
synonym: "regulation of IL-3 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032632 ! interleukin-3 production
relationship: regulates GO:0032632 ! interleukin-3 production

[Term]
id: GO:0032673
name: regulation of interleukin-4 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-4 production." [GOC:mah]
synonym: "regulation of IL-4 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032633 ! interleukin-4 production
relationship: regulates GO:0032633 ! interleukin-4 production

[Term]
id: GO:0032674
name: regulation of interleukin-5 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-5 production." [GOC:mah]
synonym: "regulation of IL-5 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032634 ! interleukin-5 production
relationship: regulates GO:0032634 ! interleukin-5 production

[Term]
id: GO:0032675
name: regulation of interleukin-6 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-6 production." [GOC:mah]
synonym: "regulation of IL-6 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032635 ! interleukin-6 production
relationship: regulates GO:0032635 ! interleukin-6 production

[Term]
id: GO:0032676
name: regulation of interleukin-7 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-7 production." [GOC:mah]
synonym: "regulation of IL-7 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032636 ! interleukin-7 production
relationship: regulates GO:0032636 ! interleukin-7 production

[Term]
id: GO:0032677
name: regulation of interleukin-8 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-8 production." [GOC:mah]
synonym: "regulation of IL-8 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032637 ! interleukin-8 production
relationship: regulates GO:0032637 ! interleukin-8 production

[Term]
id: GO:0032678
name: regulation of interleukin-9 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-9 production." [GOC:mah]
synonym: "regulation of IL-9 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032638 ! interleukin-9 production
relationship: regulates GO:0032638 ! interleukin-9 production

[Term]
id: GO:0032679
name: regulation of TRAIL production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of TRAIL production." [GOC:mah]
is_a: GO:1903555 ! regulation of tumor necrosis factor superfamily cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032639 ! TRAIL production
relationship: regulates GO:0032639 ! TRAIL production

[Term]
id: GO:0032680
name: regulation of tumor necrosis factor production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of tumor necrosis factor production." [GOC:mah]
comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF').
synonym: "regulation of TNF production" EXACT []
synonym: "regulation of TNF-alpha production" EXACT []
synonym: "regulation of tumor necrosis factor-alpha production" EXACT []
is_a: GO:1903555 ! regulation of tumor necrosis factor superfamily cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032640 ! tumor necrosis factor production
relationship: regulates GO:0032640 ! tumor necrosis factor production

[Term]
id: GO:0032681
name: regulation of lymphotoxin A production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of lymphotoxin A production." [GOC:mah]
synonym: "regulation of LTA production" EXACT []
synonym: "regulation of lymphotoxin-alpha production" EXACT []
synonym: "regulation of TNF-beta production" EXACT []
synonym: "regulation of tumor necrosis factor-beta production" EXACT []
is_a: GO:1903555 ! regulation of tumor necrosis factor superfamily cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032641 ! lymphotoxin A production
relationship: regulates GO:0032641 ! lymphotoxin A production

[Term]
id: GO:0032682
name: negative regulation of chemokine production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of chemokine production." [GOC:mah]
synonym: "down regulation of chemokine production" EXACT []
synonym: "down-regulation of chemokine production" EXACT []
synonym: "downregulation of chemokine production" EXACT []
synonym: "inhibition of chemokine production" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032642 ! regulation of chemokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032602 ! chemokine production
relationship: negatively_regulates GO:0032602 ! chemokine production

[Term]
id: GO:0032683
name: negative regulation of connective tissue growth factor production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of connective tissue growth factor production." [GOC:mah]
synonym: "down regulation of connective tissue growth factor production" EXACT []
synonym: "down-regulation of connective tissue growth factor production" EXACT []
synonym: "downregulation of connective tissue growth factor production" EXACT []
synonym: "inhibition of connective tissue growth factor production" NARROW []
synonym: "negative regulation of CCN2 production" EXACT []
synonym: "negative regulation of CTGF production" EXACT []
synonym: "negative regulation of Fisp12 production" EXACT []
synonym: "negative regulation of Hcs24 production" EXACT []
synonym: "negative regulation of hypertrophic chondrocyte-specific gene product 24 production" EXACT []
synonym: "negative regulation of IGFBP8 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032643 ! regulation of connective tissue growth factor production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032601 ! connective tissue growth factor production
relationship: negatively_regulates GO:0032601 ! connective tissue growth factor production

[Term]
id: GO:0032684
name: negative regulation of fractalkine production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of fractalkine production." [GOC:mah]
synonym: "down regulation of fractalkine production" EXACT []
synonym: "down-regulation of fractalkine production" EXACT []
synonym: "downregulation of fractalkine production" EXACT []
synonym: "inhibition of fractalkine production" NARROW []
is_a: GO:0032644 ! regulation of fractalkine production
is_a: GO:0032682 ! negative regulation of chemokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032603 ! fractalkine production
relationship: negatively_regulates GO:0032603 ! fractalkine production

[Term]
id: GO:0032685
name: negative regulation of granulocyte macrophage colony-stimulating factor production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production." [GOC:mah]
synonym: "down regulation of granulocyte macrophage colony-stimulating factor production" EXACT []
synonym: "down-regulation of granulocyte macrophage colony-stimulating factor production" EXACT []
synonym: "downregulation of granulocyte macrophage colony-stimulating factor production" EXACT []
synonym: "inhibition of granulocyte macrophage colony-stimulating factor production" NARROW []
synonym: "negative regulation of GM-CSF production" EXACT [GOC:vk]
synonym: "negative regulation of granulocyte macrophage colony stimulating factor production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032645 ! regulation of granulocyte macrophage colony-stimulating factor production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032604 ! granulocyte macrophage colony-stimulating factor production
relationship: negatively_regulates GO:0032604 ! granulocyte macrophage colony-stimulating factor production

[Term]
id: GO:0032686
name: negative regulation of hepatocyte growth factor production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of hepatocyte growth factor production." [GOC:mah]
synonym: "down regulation of hepatocyte growth factor production" EXACT []
synonym: "down-regulation of hepatocyte growth factor production" EXACT []
synonym: "downregulation of hepatocyte growth factor production" EXACT []
synonym: "inhibition of hepatocyte growth factor production" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032646 ! regulation of hepatocyte growth factor production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032605 ! hepatocyte growth factor production
relationship: negatively_regulates GO:0032605 ! hepatocyte growth factor production

[Term]
id: GO:0032687
name: negative regulation of interferon-alpha production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-alpha production." [GOC:mah]
synonym: "down regulation of interferon-alpha production" EXACT []
synonym: "down-regulation of interferon-alpha production" EXACT []
synonym: "downregulation of interferon-alpha production" EXACT []
synonym: "inhibition of interferon-alpha production" NARROW []
is_a: GO:0032480 ! negative regulation of type I interferon production
is_a: GO:0032647 ! regulation of interferon-alpha production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032607 ! interferon-alpha production
relationship: negatively_regulates GO:0032607 ! interferon-alpha production

[Term]
id: GO:0032688
name: negative regulation of interferon-beta production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-beta production." [GOC:mah]
synonym: "down regulation of interferon-beta production" EXACT []
synonym: "down-regulation of interferon-beta production" EXACT []
synonym: "downregulation of interferon-beta production" EXACT []
synonym: "inhibition of interferon-beta production" NARROW []
synonym: "negative regulation of IFN-beta production" EXACT []
is_a: GO:0032480 ! negative regulation of type I interferon production
is_a: GO:0032648 ! regulation of interferon-beta production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032608 ! interferon-beta production
relationship: negatively_regulates GO:0032608 ! interferon-beta production

[Term]
id: GO:0032689
name: negative regulation of interferon-gamma production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:mah]
synonym: "down regulation of interferon-gamma production" EXACT []
synonym: "down-regulation of interferon-gamma production" EXACT []
synonym: "downregulation of interferon-gamma production" EXACT []
synonym: "inhibition of interferon-gamma production" NARROW []
synonym: "negative regulation of type II interferon production" BROAD []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032649 ! regulation of interferon-gamma production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032609 ! interferon-gamma production
relationship: negatively_regulates GO:0032609 ! interferon-gamma production

[Term]
id: GO:0032690
name: negative regulation of interleukin-1 alpha production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 alpha production." [GOC:mah]
synonym: "down regulation of interleukin-1 alpha production" EXACT []
synonym: "down-regulation of interleukin-1 alpha production" EXACT []
synonym: "downregulation of interleukin-1 alpha production" EXACT []
synonym: "inhibition of interleukin-1 alpha production" NARROW []
synonym: "negative regulation of IL-1 alpha production" EXACT []
is_a: GO:0032650 ! regulation of interleukin-1 alpha production
is_a: GO:0032692 ! negative regulation of interleukin-1 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032610 ! interleukin-1 alpha production
relationship: negatively_regulates GO:0032610 ! interleukin-1 alpha production

[Term]
id: GO:0032691
name: negative regulation of interleukin-1 beta production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 beta production." [GOC:mah]
synonym: "down regulation of interleukin-1 beta production" EXACT []
synonym: "down-regulation of interleukin-1 beta production" EXACT []
synonym: "downregulation of interleukin-1 beta production" EXACT []
synonym: "inhibition of interleukin-1 beta production" NARROW []
synonym: "negative regulation of IL-1 beta production" EXACT []
is_a: GO:0032651 ! regulation of interleukin-1 beta production
is_a: GO:0032692 ! negative regulation of interleukin-1 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032611 ! interleukin-1 beta production
relationship: negatively_regulates GO:0032611 ! interleukin-1 beta production

[Term]
id: GO:0032692
name: negative regulation of interleukin-1 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 production." [GOC:mah]
synonym: "down regulation of interleukin-1 production" EXACT []
synonym: "down-regulation of interleukin-1 production" EXACT []
synonym: "downregulation of interleukin-1 production" EXACT []
synonym: "inhibition of interleukin-1 production" NARROW []
synonym: "negative regulation of IL-1 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032652 ! regulation of interleukin-1 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032612 ! interleukin-1 production
relationship: negatively_regulates GO:0032612 ! interleukin-1 production

[Term]
id: GO:0032693
name: negative regulation of interleukin-10 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-10 production." [GOC:mah]
synonym: "down regulation of interleukin-10 production" EXACT []
synonym: "down-regulation of interleukin-10 production" EXACT []
synonym: "downregulation of interleukin-10 production" EXACT []
synonym: "inhibition of interleukin-10 production" NARROW []
synonym: "negative regulation of IL-10 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032653 ! regulation of interleukin-10 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032613 ! interleukin-10 production
relationship: negatively_regulates GO:0032613 ! interleukin-10 production

[Term]
id: GO:0032694
name: negative regulation of interleukin-11 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-11 production." [GOC:mah]
synonym: "down regulation of interleukin-11 production" EXACT []
synonym: "down-regulation of interleukin-11 production" EXACT []
synonym: "downregulation of interleukin-11 production" EXACT []
synonym: "inhibition of interleukin-11 production" NARROW []
synonym: "negative regulation of IL-11 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032654 ! regulation of interleukin-11 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032614 ! interleukin-11 production
relationship: negatively_regulates GO:0032614 ! interleukin-11 production

[Term]
id: GO:0032695
name: negative regulation of interleukin-12 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-12 production." [GOC:mah]
synonym: "down regulation of interleukin-12 production" EXACT []
synonym: "down-regulation of interleukin-12 production" EXACT []
synonym: "downregulation of interleukin-12 production" EXACT []
synonym: "inhibition of interleukin-12 production" NARROW []
synonym: "negative regulation of IL-12 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032655 ! regulation of interleukin-12 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032615 ! interleukin-12 production
relationship: negatively_regulates GO:0032615 ! interleukin-12 production

[Term]
id: GO:0032696
name: negative regulation of interleukin-13 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-13 production." [GOC:mah]
synonym: "down regulation of interleukin-13 production" EXACT []
synonym: "down-regulation of interleukin-13 production" EXACT []
synonym: "downregulation of interleukin-13 production" EXACT []
synonym: "inhibition of interleukin-13 production" NARROW []
synonym: "negative regulation of IL-13 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032656 ! regulation of interleukin-13 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032616 ! interleukin-13 production
relationship: negatively_regulates GO:0032616 ! interleukin-13 production

[Term]
id: GO:0032697
name: negative regulation of interleukin-14 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-14 production." [GOC:mah]
synonym: "down regulation of interleukin-14 production" EXACT []
synonym: "down-regulation of interleukin-14 production" EXACT []
synonym: "downregulation of interleukin-14 production" EXACT []
synonym: "inhibition of interleukin-14 production" NARROW []
synonym: "negative regulation of IL-14 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032657 ! regulation of interleukin-14 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032617 ! interleukin-14 production
relationship: negatively_regulates GO:0032617 ! interleukin-14 production

[Term]
id: GO:0032698
name: negative regulation of interleukin-15 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-15 production." [GOC:mah]
synonym: "down regulation of interleukin-15 production" EXACT []
synonym: "down-regulation of interleukin-15 production" EXACT []
synonym: "downregulation of interleukin-15 production" EXACT []
synonym: "inhibition of interleukin-15 production" NARROW []
synonym: "negative regulation of IL-15 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032658 ! regulation of interleukin-15 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032618 ! interleukin-15 production
relationship: negatively_regulates GO:0032618 ! interleukin-15 production

[Term]
id: GO:0032699
name: negative regulation of interleukin-16 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-16 production." [GOC:mah]
synonym: "down regulation of interleukin-16 production" EXACT []
synonym: "down-regulation of interleukin-16 production" EXACT []
synonym: "downregulation of interleukin-16 production" EXACT []
synonym: "inhibition of interleukin-16 production" NARROW []
synonym: "negative regulation of IL-16 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032659 ! regulation of interleukin-16 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032619 ! interleukin-16 production
relationship: negatively_regulates GO:0032619 ! interleukin-16 production

[Term]
id: GO:0032700
name: negative regulation of interleukin-17 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines." [GOC:add, GOC:mah]
synonym: "down regulation of interleukin-17 production" EXACT []
synonym: "down-regulation of interleukin-17 production" EXACT []
synonym: "downregulation of interleukin-17 production" EXACT []
synonym: "inhibition of interleukin-17 production" NARROW []
synonym: "negative regulation of IL-17 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032660 ! regulation of interleukin-17 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032620 ! interleukin-17 production
relationship: negatively_regulates GO:0032620 ! interleukin-17 production

[Term]
id: GO:0032701
name: negative regulation of interleukin-18 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-18 production." [GOC:mah]
synonym: "down regulation of interleukin-18 production" EXACT []
synonym: "down-regulation of interleukin-18 production" EXACT []
synonym: "downregulation of interleukin-18 production" EXACT []
synonym: "inhibition of interleukin-18 production" NARROW []
synonym: "negative regulation of IL-18 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032661 ! regulation of interleukin-18 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032621 ! interleukin-18 production
relationship: negatively_regulates GO:0032621 ! interleukin-18 production

[Term]
id: GO:0032702
name: negative regulation of interleukin-19 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-19 production." [GOC:mah]
synonym: "down regulation of interleukin-19 production" EXACT []
synonym: "down-regulation of interleukin-19 production" EXACT []
synonym: "downregulation of interleukin-19 production" EXACT []
synonym: "inhibition of interleukin-19 production" NARROW []
synonym: "negative regulation of IL-19 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032662 ! regulation of interleukin-19 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032622 ! interleukin-19 production
relationship: negatively_regulates GO:0032622 ! interleukin-19 production

[Term]
id: GO:0032703
name: negative regulation of interleukin-2 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production." [GOC:mah]
synonym: "down regulation of interleukin-2 production" EXACT []
synonym: "down-regulation of interleukin-2 production" EXACT []
synonym: "downregulation of interleukin-2 production" EXACT []
synonym: "inhibition of interleukin-2 production" NARROW []
synonym: "negative regulation of IL-2 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032663 ! regulation of interleukin-2 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032623 ! interleukin-2 production
relationship: negatively_regulates GO:0032623 ! interleukin-2 production

[Term]
id: GO:0032704
name: negative regulation of interleukin-20 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-20 production." [GOC:mah]
synonym: "down regulation of interleukin-20 production" EXACT []
synonym: "down-regulation of interleukin-20 production" EXACT []
synonym: "downregulation of interleukin-20 production" EXACT []
synonym: "inhibition of interleukin-20 production" NARROW []
synonym: "negative regulation of IL-20 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032664 ! regulation of interleukin-20 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032624 ! interleukin-20 production
relationship: negatively_regulates GO:0032624 ! interleukin-20 production

[Term]
id: GO:0032705
name: negative regulation of interleukin-21 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-21 production." [GOC:mah]
synonym: "down regulation of interleukin-21 production" EXACT []
synonym: "down-regulation of interleukin-21 production" EXACT []
synonym: "downregulation of interleukin-21 production" EXACT []
synonym: "inhibition of interleukin-21 production" NARROW []
synonym: "negative regulation of IL-21 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032665 ! regulation of interleukin-21 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032625 ! interleukin-21 production
relationship: negatively_regulates GO:0032625 ! interleukin-21 production

[Term]
id: GO:0032706
name: negative regulation of interleukin-22 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-22 production." [GOC:mah]
synonym: "down regulation of interleukin-22 production" EXACT []
synonym: "down-regulation of interleukin-22 production" EXACT []
synonym: "downregulation of interleukin-22 production" EXACT []
synonym: "inhibition of interleukin-22 production" NARROW []
synonym: "negative regulation of IL-22 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032666 ! regulation of interleukin-22 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032626 ! interleukin-22 production
relationship: negatively_regulates GO:0032626 ! interleukin-22 production

[Term]
id: GO:0032707
name: negative regulation of interleukin-23 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-23 production." [GOC:mah]
synonym: "down regulation of interleukin-23 production" EXACT []
synonym: "down-regulation of interleukin-23 production" EXACT []
synonym: "downregulation of interleukin-23 production" EXACT []
synonym: "inhibition of interleukin-23 production" NARROW []
synonym: "negative regulation of IL-23 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032667 ! regulation of interleukin-23 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032627 ! interleukin-23 production
relationship: negatively_regulates GO:0032627 ! interleukin-23 production

[Term]
id: GO:0032708
name: negative regulation of interleukin-24 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-24 production." [GOC:mah]
synonym: "down regulation of interleukin-24 production" EXACT []
synonym: "down-regulation of interleukin-24 production" EXACT []
synonym: "downregulation of interleukin-24 production" EXACT []
synonym: "inhibition of interleukin-24 production" NARROW []
synonym: "negative regulation of IL-24 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032668 ! regulation of interleukin-24 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032628 ! interleukin-24 production
relationship: negatively_regulates GO:0032628 ! interleukin-24 production

[Term]
id: GO:0032709
name: negative regulation of interleukin-25 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-25 production." [GOC:mah]
synonym: "down regulation of interleukin-25 production" EXACT []
synonym: "down-regulation of interleukin-25 production" EXACT []
synonym: "downregulation of interleukin-25 production" EXACT []
synonym: "inhibition of interleukin-25 production" NARROW []
synonym: "negative regulation of IL-25 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032669 ! regulation of interleukin-25 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032629 ! interleukin-25 production
relationship: negatively_regulates GO:0032629 ! interleukin-25 production

[Term]
id: GO:0032710
name: negative regulation of interleukin-26 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-26 production." [GOC:mah]
synonym: "down regulation of interleukin-26 production" EXACT []
synonym: "down-regulation of interleukin-26 production" EXACT []
synonym: "downregulation of interleukin-26 production" EXACT []
synonym: "inhibition of interleukin-26 production" NARROW []
synonym: "negative regulation of IL-26 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032670 ! regulation of interleukin-26 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032630 ! interleukin-26 production
relationship: negatively_regulates GO:0032630 ! interleukin-26 production

[Term]
id: GO:0032711
name: negative regulation of interleukin-27 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-27 production." [GOC:mah]
synonym: "down regulation of interleukin-27 production" EXACT []
synonym: "down-regulation of interleukin-27 production" EXACT []
synonym: "downregulation of interleukin-27 production" EXACT []
synonym: "inhibition of interleukin-27 production" NARROW []
synonym: "negative regulation of IL-27 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032671 ! regulation of interleukin-27 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032631 ! interleukin-27 production
relationship: negatively_regulates GO:0032631 ! interleukin-27 production

[Term]
id: GO:0032712
name: negative regulation of interleukin-3 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-3 production." [GOC:mah]
synonym: "down regulation of interleukin-3 production" EXACT []
synonym: "down-regulation of interleukin-3 production" EXACT []
synonym: "downregulation of interleukin-3 production" EXACT []
synonym: "inhibition of interleukin-3 production" NARROW []
synonym: "negative regulation of IL-3 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032672 ! regulation of interleukin-3 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032632 ! interleukin-3 production
relationship: negatively_regulates GO:0032632 ! interleukin-3 production

[Term]
id: GO:0032713
name: negative regulation of interleukin-4 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-4 production." [GOC:mah]
synonym: "down regulation of interleukin-4 production" EXACT []
synonym: "down-regulation of interleukin-4 production" EXACT []
synonym: "downregulation of interleukin-4 production" EXACT []
synonym: "inhibition of interleukin-4 production" NARROW []
synonym: "negative regulation of IL-4 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032673 ! regulation of interleukin-4 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032633 ! interleukin-4 production
relationship: negatively_regulates GO:0032633 ! interleukin-4 production

[Term]
id: GO:0032714
name: negative regulation of interleukin-5 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-5 production." [GOC:mah]
synonym: "down regulation of interleukin-5 production" EXACT []
synonym: "down-regulation of interleukin-5 production" EXACT []
synonym: "downregulation of interleukin-5 production" EXACT []
synonym: "inhibition of interleukin-5 production" NARROW []
synonym: "negative regulation of IL-5 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032674 ! regulation of interleukin-5 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032634 ! interleukin-5 production
relationship: negatively_regulates GO:0032634 ! interleukin-5 production

[Term]
id: GO:0032715
name: negative regulation of interleukin-6 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production." [GOC:mah]
synonym: "down regulation of interleukin-6 production" EXACT []
synonym: "down-regulation of interleukin-6 production" EXACT []
synonym: "downregulation of interleukin-6 production" EXACT []
synonym: "inhibition of interleukin-6 production" NARROW []
synonym: "negative regulation of IL-6 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032675 ! regulation of interleukin-6 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032635 ! interleukin-6 production
relationship: negatively_regulates GO:0032635 ! interleukin-6 production

[Term]
id: GO:0032716
name: negative regulation of interleukin-7 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-7 production." [GOC:mah]
synonym: "down regulation of interleukin-7 production" EXACT []
synonym: "down-regulation of interleukin-7 production" EXACT []
synonym: "downregulation of interleukin-7 production" EXACT []
synonym: "inhibition of interleukin-7 production" NARROW []
synonym: "negative regulation of IL-7 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032676 ! regulation of interleukin-7 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032636 ! interleukin-7 production
relationship: negatively_regulates GO:0032636 ! interleukin-7 production

[Term]
id: GO:0032717
name: negative regulation of interleukin-8 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-8 production." [GOC:mah]
synonym: "down regulation of interleukin-8 production" EXACT []
synonym: "down-regulation of interleukin-8 production" EXACT []
synonym: "downregulation of interleukin-8 production" EXACT []
synonym: "inhibition of interleukin-8 production" NARROW []
synonym: "negative regulation of IL-8 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032677 ! regulation of interleukin-8 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032637 ! interleukin-8 production
relationship: negatively_regulates GO:0032637 ! interleukin-8 production

[Term]
id: GO:0032718
name: negative regulation of interleukin-9 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-9 production." [GOC:mah]
synonym: "down regulation of interleukin-9 production" EXACT []
synonym: "down-regulation of interleukin-9 production" EXACT []
synonym: "downregulation of interleukin-9 production" EXACT []
synonym: "inhibition of interleukin-9 production" NARROW []
synonym: "negative regulation of IL-9 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032678 ! regulation of interleukin-9 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032638 ! interleukin-9 production
relationship: negatively_regulates GO:0032638 ! interleukin-9 production

[Term]
id: GO:0032719
name: negative regulation of TRAIL production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of TRAIL production." [GOC:mah]
synonym: "down regulation of TRAIL production" EXACT []
synonym: "down-regulation of TRAIL production" EXACT []
synonym: "downregulation of TRAIL production" EXACT []
synonym: "inhibition of TRAIL production" NARROW []
is_a: GO:0032679 ! regulation of TRAIL production
is_a: GO:1903556 ! negative regulation of tumor necrosis factor superfamily cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032639 ! TRAIL production
relationship: negatively_regulates GO:0032639 ! TRAIL production

[Term]
id: GO:0032720
name: negative regulation of tumor necrosis factor production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production." [GOC:mah]
comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF').
synonym: "down regulation of tumor necrosis factor production" EXACT []
synonym: "down-regulation of tumor necrosis factor production" EXACT []
synonym: "downregulation of tumor necrosis factor production" EXACT []
synonym: "inhibition of tumor necrosis factor production" NARROW []
synonym: "negative regulation TNF production" EXACT []
synonym: "negative regulation TNF-alpha production" EXACT []
synonym: "negative regulation tumor necrosis factor-alpha production" EXACT []
is_a: GO:0032680 ! regulation of tumor necrosis factor production
is_a: GO:1903556 ! negative regulation of tumor necrosis factor superfamily cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032640 ! tumor necrosis factor production
relationship: negatively_regulates GO:0032640 ! tumor necrosis factor production

[Term]
id: GO:0032721
name: negative regulation of lymphotoxin A production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphotoxin A production." [GOC:mah]
synonym: "down regulation of lymphotoxin A production" EXACT []
synonym: "down-regulation of lymphotoxin A production" EXACT []
synonym: "downregulation of lymphotoxin A production" EXACT []
synonym: "inhibition of lymphotoxin A production" NARROW []
synonym: "negative regulation of LTA production" EXACT []
synonym: "negative regulation of lymphotoxin-alpha production" EXACT []
synonym: "negative regulation of TNF-beta production" EXACT []
synonym: "negative regulation of tumor necrosis factor-beta production" EXACT []
is_a: GO:0032681 ! regulation of lymphotoxin A production
is_a: GO:1903556 ! negative regulation of tumor necrosis factor superfamily cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032641 ! lymphotoxin A production
relationship: negatively_regulates GO:0032641 ! lymphotoxin A production

[Term]
id: GO:0032722
name: positive regulation of chemokine production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of chemokine production." [GOC:mah]
synonym: "activation of chemokine production" NARROW []
synonym: "stimulation of chemokine production" NARROW []
synonym: "up regulation of chemokine production" EXACT []
synonym: "up-regulation of chemokine production" EXACT []
synonym: "upregulation of chemokine production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032642 ! regulation of chemokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032602 ! chemokine production
relationship: positively_regulates GO:0032602 ! chemokine production

[Term]
id: GO:0032723
name: positive regulation of connective tissue growth factor production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of connective tissue growth factor production." [GOC:mah]
synonym: "activation of connective tissue growth factor production" NARROW []
synonym: "positive regulation of CCN2 production" EXACT []
synonym: "positive regulation of CTGF production" EXACT []
synonym: "positive regulation of Fisp12 production" EXACT []
synonym: "positive regulation of Hcs24 production" EXACT []
synonym: "positive regulation of hypertrophic chondrocyte-specific gene product 24 production" EXACT []
synonym: "positive regulation of IGFBP8 production" EXACT []
synonym: "stimulation of connective tissue growth factor production" NARROW []
synonym: "up regulation of connective tissue growth factor production" EXACT []
synonym: "up-regulation of connective tissue growth factor production" EXACT []
synonym: "upregulation of connective tissue growth factor production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032643 ! regulation of connective tissue growth factor production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032601 ! connective tissue growth factor production
relationship: positively_regulates GO:0032601 ! connective tissue growth factor production

[Term]
id: GO:0032724
name: positive regulation of fractalkine production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of fractalkine production." [GOC:mah]
synonym: "activation of fractalkine production" NARROW []
synonym: "stimulation of fractalkine production" NARROW []
synonym: "up regulation of fractalkine production" EXACT []
synonym: "up-regulation of fractalkine production" EXACT []
synonym: "upregulation of fractalkine production" EXACT []
is_a: GO:0032644 ! regulation of fractalkine production
is_a: GO:0032722 ! positive regulation of chemokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032603 ! fractalkine production
relationship: positively_regulates GO:0032603 ! fractalkine production

[Term]
id: GO:0032725
name: positive regulation of granulocyte macrophage colony-stimulating factor production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production." [GOC:mah]
synonym: "activation of granulocyte macrophage colony-stimulating factor production" NARROW []
synonym: "positive regulation of GM-CSF production" EXACT [GOC:vk]
synonym: "positive regulation of granulocyte macrophage colony stimulating factor production" EXACT []
synonym: "stimulation of granulocyte macrophage colony-stimulating factor production" NARROW []
synonym: "up regulation of granulocyte macrophage colony-stimulating factor production" EXACT []
synonym: "up-regulation of granulocyte macrophage colony-stimulating factor production" EXACT []
synonym: "upregulation of granulocyte macrophage colony-stimulating factor production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032645 ! regulation of granulocyte macrophage colony-stimulating factor production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032604 ! granulocyte macrophage colony-stimulating factor production
relationship: positively_regulates GO:0032604 ! granulocyte macrophage colony-stimulating factor production

[Term]
id: GO:0032726
name: positive regulation of hepatocyte growth factor production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of hepatocyte growth factor production." [GOC:mah]
synonym: "activation of hepatocyte growth factor production" NARROW []
synonym: "stimulation of hepatocyte growth factor production" NARROW []
synonym: "up regulation of hepatocyte growth factor production" EXACT []
synonym: "up-regulation of hepatocyte growth factor production" EXACT []
synonym: "upregulation of hepatocyte growth factor production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032646 ! regulation of hepatocyte growth factor production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032605 ! hepatocyte growth factor production
relationship: positively_regulates GO:0032605 ! hepatocyte growth factor production

[Term]
id: GO:0032727
name: positive regulation of interferon-alpha production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interferon-alpha production." [GOC:mah]
synonym: "activation of interferon-alpha production" NARROW []
synonym: "stimulation of interferon-alpha production" NARROW []
synonym: "up regulation of interferon-alpha production" EXACT []
synonym: "up-regulation of interferon-alpha production" EXACT []
synonym: "upregulation of interferon-alpha production" EXACT []
is_a: GO:0032481 ! positive regulation of type I interferon production
is_a: GO:0032647 ! regulation of interferon-alpha production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032607 ! interferon-alpha production
relationship: positively_regulates GO:0032607 ! interferon-alpha production

[Term]
id: GO:0032728
name: positive regulation of interferon-beta production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interferon-beta production." [GOC:mah]
synonym: "activation of interferon-beta production" NARROW []
synonym: "positive regulation of IFN-beta production" EXACT []
synonym: "stimulation of interferon-beta production" NARROW []
synonym: "up regulation of interferon-beta production" EXACT []
synonym: "up-regulation of interferon-beta production" EXACT []
synonym: "upregulation of interferon-beta production" EXACT []
is_a: GO:0032481 ! positive regulation of type I interferon production
is_a: GO:0032648 ! regulation of interferon-beta production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032608 ! interferon-beta production
relationship: positively_regulates GO:0032608 ! interferon-beta production

[Term]
id: GO:0032729
name: positive regulation of interferon-gamma production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:mah]
synonym: "activation of interferon-gamma production" NARROW []
synonym: "positive regulation of type II interferon production" BROAD []
synonym: "stimulation of interferon-gamma production" NARROW []
synonym: "up regulation of interferon-gamma production" EXACT []
synonym: "up-regulation of interferon-gamma production" EXACT []
synonym: "upregulation of interferon-gamma production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032649 ! regulation of interferon-gamma production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032609 ! interferon-gamma production
relationship: positively_regulates GO:0032609 ! interferon-gamma production

[Term]
id: GO:0032730
name: positive regulation of interleukin-1 alpha production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-1 alpha production." [GOC:mah]
synonym: "activation of interleukin-1 alpha production" NARROW []
synonym: "positive regulation of IL-1 alpha production" EXACT []
synonym: "stimulation of interleukin-1 alpha production" NARROW []
synonym: "up regulation of interleukin-1 alpha production" EXACT []
synonym: "up-regulation of interleukin-1 alpha production" EXACT []
synonym: "upregulation of interleukin-1 alpha production" EXACT []
is_a: GO:0032650 ! regulation of interleukin-1 alpha production
is_a: GO:0032732 ! positive regulation of interleukin-1 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032610 ! interleukin-1 alpha production
relationship: positively_regulates GO:0032610 ! interleukin-1 alpha production

[Term]
id: GO:0032731
name: positive regulation of interleukin-1 beta production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-1 beta production." [GOC:mah]
synonym: "activation of interleukin-1 beta production" NARROW []
synonym: "positive regulation of IL-1 beta production" EXACT []
synonym: "stimulation of interleukin-1 beta production" NARROW []
synonym: "up regulation of interleukin-1 beta production" EXACT []
synonym: "up-regulation of interleukin-1 beta production" EXACT []
synonym: "upregulation of interleukin-1 beta production" EXACT []
is_a: GO:0032651 ! regulation of interleukin-1 beta production
is_a: GO:0032732 ! positive regulation of interleukin-1 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032611 ! interleukin-1 beta production
relationship: positively_regulates GO:0032611 ! interleukin-1 beta production

[Term]
id: GO:0032732
name: positive regulation of interleukin-1 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-1 production." [GOC:mah]
synonym: "activation of interleukin-1 production" NARROW []
synonym: "positive regulation of IL-1 production" EXACT []
synonym: "stimulation of interleukin-1 production" NARROW []
synonym: "up regulation of interleukin-1 production" EXACT []
synonym: "up-regulation of interleukin-1 production" EXACT []
synonym: "upregulation of interleukin-1 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032652 ! regulation of interleukin-1 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032612 ! interleukin-1 production
relationship: positively_regulates GO:0032612 ! interleukin-1 production

[Term]
id: GO:0032733
name: positive regulation of interleukin-10 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-10 production." [GOC:mah]
synonym: "activation of interleukin-10 production" NARROW []
synonym: "positive regulation of IL-10 production" EXACT []
synonym: "stimulation of interleukin-10 production" NARROW []
synonym: "up regulation of interleukin-10 production" EXACT []
synonym: "up-regulation of interleukin-10 production" EXACT []
synonym: "upregulation of interleukin-10 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032653 ! regulation of interleukin-10 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032613 ! interleukin-10 production
relationship: positively_regulates GO:0032613 ! interleukin-10 production

[Term]
id: GO:0032734
name: positive regulation of interleukin-11 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-11 production." [GOC:mah]
synonym: "activation of interleukin-11 production" NARROW []
synonym: "positive regulation of IL-11 production" EXACT []
synonym: "stimulation of interleukin-11 production" NARROW []
synonym: "up regulation of interleukin-11 production" EXACT []
synonym: "up-regulation of interleukin-11 production" EXACT []
synonym: "upregulation of interleukin-11 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032654 ! regulation of interleukin-11 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032614 ! interleukin-11 production
relationship: positively_regulates GO:0032614 ! interleukin-11 production

[Term]
id: GO:0032735
name: positive regulation of interleukin-12 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-12 production." [GOC:mah]
synonym: "activation of interleukin-12 production" NARROW []
synonym: "positive regulation of IL-12 production" EXACT []
synonym: "stimulation of interleukin-12 production" NARROW []
synonym: "up regulation of interleukin-12 production" EXACT []
synonym: "up-regulation of interleukin-12 production" EXACT []
synonym: "upregulation of interleukin-12 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032655 ! regulation of interleukin-12 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032615 ! interleukin-12 production
relationship: positively_regulates GO:0032615 ! interleukin-12 production

[Term]
id: GO:0032736
name: positive regulation of interleukin-13 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-13 production." [GOC:mah]
synonym: "activation of interleukin-13 production" NARROW []
synonym: "positive regulation of IL-13 production" EXACT []
synonym: "stimulation of interleukin-13 production" NARROW []
synonym: "up regulation of interleukin-13 production" EXACT []
synonym: "up-regulation of interleukin-13 production" EXACT []
synonym: "upregulation of interleukin-13 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032656 ! regulation of interleukin-13 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032616 ! interleukin-13 production
relationship: positively_regulates GO:0032616 ! interleukin-13 production

[Term]
id: GO:0032737
name: positive regulation of interleukin-14 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-14 production." [GOC:mah]
synonym: "activation of interleukin-14 production" NARROW []
synonym: "positive regulation of IL-14 production" EXACT []
synonym: "stimulation of interleukin-14 production" NARROW []
synonym: "up regulation of interleukin-14 production" EXACT []
synonym: "up-regulation of interleukin-14 production" EXACT []
synonym: "upregulation of interleukin-14 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032657 ! regulation of interleukin-14 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032617 ! interleukin-14 production
relationship: positively_regulates GO:0032617 ! interleukin-14 production

[Term]
id: GO:0032738
name: positive regulation of interleukin-15 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-15 production." [GOC:mah]
synonym: "activation of interleukin-15 production" NARROW []
synonym: "positive regulation of IL-15 production" EXACT []
synonym: "stimulation of interleukin-15 production" NARROW []
synonym: "up regulation of interleukin-15 production" EXACT []
synonym: "up-regulation of interleukin-15 production" EXACT []
synonym: "upregulation of interleukin-15 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032658 ! regulation of interleukin-15 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032618 ! interleukin-15 production
relationship: positively_regulates GO:0032618 ! interleukin-15 production

[Term]
id: GO:0032739
name: positive regulation of interleukin-16 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-16 production." [GOC:mah]
synonym: "activation of interleukin-16 production" NARROW []
synonym: "positive regulation of IL-16 production" EXACT []
synonym: "stimulation of interleukin-16 production" NARROW []
synonym: "up regulation of interleukin-16 production" EXACT []
synonym: "up-regulation of interleukin-16 production" EXACT []
synonym: "upregulation of interleukin-16 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032659 ! regulation of interleukin-16 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032619 ! interleukin-16 production
relationship: positively_regulates GO:0032619 ! interleukin-16 production

[Term]
id: GO:0032740
name: positive regulation of interleukin-17 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines." [GOC:add, GOC:mah]
synonym: "activation of interleukin-17 production" NARROW []
synonym: "positive regulation of IL-17 production" EXACT []
synonym: "stimulation of interleukin-17 production" NARROW []
synonym: "up regulation of interleukin-17 production" EXACT []
synonym: "up-regulation of interleukin-17 production" EXACT []
synonym: "upregulation of interleukin-17 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032660 ! regulation of interleukin-17 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032620 ! interleukin-17 production
relationship: positively_regulates GO:0032620 ! interleukin-17 production

[Term]
id: GO:0032741
name: positive regulation of interleukin-18 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-18 production." [GOC:mah]
synonym: "activation of interleukin-18 production" NARROW []
synonym: "positive regulation of IL-18 production" EXACT []
synonym: "stimulation of interleukin-18 production" NARROW []
synonym: "up regulation of interleukin-18 production" EXACT []
synonym: "up-regulation of interleukin-18 production" EXACT []
synonym: "upregulation of interleukin-18 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032661 ! regulation of interleukin-18 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032621 ! interleukin-18 production
relationship: positively_regulates GO:0032621 ! interleukin-18 production

[Term]
id: GO:0032742
name: positive regulation of interleukin-19 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-19 production." [GOC:mah]
synonym: "activation of interleukin-19 production" NARROW []
synonym: "positive regulation of IL-19 production" EXACT []
synonym: "stimulation of interleukin-19 production" NARROW []
synonym: "up regulation of interleukin-19 production" EXACT []
synonym: "up-regulation of interleukin-19 production" EXACT []
synonym: "upregulation of interleukin-19 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032662 ! regulation of interleukin-19 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032622 ! interleukin-19 production
relationship: positively_regulates GO:0032622 ! interleukin-19 production

[Term]
id: GO:0032743
name: positive regulation of interleukin-2 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-2 production." [GOC:mah]
synonym: "activation of interleukin-2 production" NARROW []
synonym: "positive regulation of IL-2 production" EXACT []
synonym: "stimulation of interleukin-2 production" NARROW []
synonym: "up regulation of interleukin-2 production" EXACT []
synonym: "up-regulation of interleukin-2 production" EXACT []
synonym: "upregulation of interleukin-2 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032663 ! regulation of interleukin-2 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032623 ! interleukin-2 production
relationship: positively_regulates GO:0032623 ! interleukin-2 production

[Term]
id: GO:0032744
name: positive regulation of interleukin-20 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-20 production." [GOC:mah]
synonym: "activation of interleukin-20 production" NARROW []
synonym: "positive regulation of IL-20 production" EXACT []
synonym: "stimulation of interleukin-20 production" NARROW []
synonym: "up regulation of interleukin-20 production" EXACT []
synonym: "up-regulation of interleukin-20 production" EXACT []
synonym: "upregulation of interleukin-20 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032664 ! regulation of interleukin-20 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032624 ! interleukin-20 production
relationship: positively_regulates GO:0032624 ! interleukin-20 production

[Term]
id: GO:0032745
name: positive regulation of interleukin-21 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-21 production." [GOC:mah]
synonym: "activation of interleukin-21 production" NARROW []
synonym: "positive regulation of IL-21 production" EXACT []
synonym: "stimulation of interleukin-21 production" NARROW []
synonym: "up regulation of interleukin-21 production" EXACT []
synonym: "up-regulation of interleukin-21 production" EXACT []
synonym: "upregulation of interleukin-21 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032665 ! regulation of interleukin-21 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032625 ! interleukin-21 production
relationship: positively_regulates GO:0032625 ! interleukin-21 production

[Term]
id: GO:0032746
name: positive regulation of interleukin-22 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-22 production." [GOC:mah]
synonym: "activation of interleukin-22 production" NARROW []
synonym: "positive regulation of IL-22 production" EXACT []
synonym: "stimulation of interleukin-22 production" NARROW []
synonym: "up regulation of interleukin-22 production" EXACT []
synonym: "up-regulation of interleukin-22 production" EXACT []
synonym: "upregulation of interleukin-22 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032666 ! regulation of interleukin-22 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032626 ! interleukin-22 production
relationship: positively_regulates GO:0032626 ! interleukin-22 production

[Term]
id: GO:0032747
name: positive regulation of interleukin-23 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-23 production." [GOC:mah]
synonym: "activation of interleukin-23 production" NARROW []
synonym: "positive regulation of IL-23 production" EXACT []
synonym: "stimulation of interleukin-23 production" NARROW []
synonym: "up regulation of interleukin-23 production" EXACT []
synonym: "up-regulation of interleukin-23 production" EXACT []
synonym: "upregulation of interleukin-23 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032667 ! regulation of interleukin-23 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032627 ! interleukin-23 production
relationship: positively_regulates GO:0032627 ! interleukin-23 production

[Term]
id: GO:0032748
name: positive regulation of interleukin-24 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-24 production." [GOC:mah]
synonym: "activation of interleukin-24 production" NARROW []
synonym: "positive regulation of IL-24 production" EXACT []
synonym: "stimulation of interleukin-24 production" NARROW []
synonym: "up regulation of interleukin-24 production" EXACT []
synonym: "up-regulation of interleukin-24 production" EXACT []
synonym: "upregulation of interleukin-24 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032668 ! regulation of interleukin-24 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032628 ! interleukin-24 production
relationship: positively_regulates GO:0032628 ! interleukin-24 production

[Term]
id: GO:0032749
name: positive regulation of interleukin-25 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-25 production." [GOC:mah]
synonym: "activation of interleukin-25 production" NARROW []
synonym: "positive regulation of IL-25 production" EXACT []
synonym: "stimulation of interleukin-25 production" NARROW []
synonym: "up regulation of interleukin-25 production" EXACT []
synonym: "up-regulation of interleukin-25 production" EXACT []
synonym: "upregulation of interleukin-25 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032669 ! regulation of interleukin-25 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032629 ! interleukin-25 production
relationship: positively_regulates GO:0032629 ! interleukin-25 production

[Term]
id: GO:0032750
name: positive regulation of interleukin-26 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-26 production." [GOC:mah]
synonym: "activation of interleukin-26 production" NARROW []
synonym: "positive regulation of IL-26 production" EXACT []
synonym: "stimulation of interleukin-26 production" NARROW []
synonym: "up regulation of interleukin-26 production" EXACT []
synonym: "up-regulation of interleukin-26 production" EXACT []
synonym: "upregulation of interleukin-26 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032670 ! regulation of interleukin-26 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032630 ! interleukin-26 production
relationship: positively_regulates GO:0032630 ! interleukin-26 production

[Term]
id: GO:0032751
name: positive regulation of interleukin-27 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-27 production." [GOC:mah]
synonym: "activation of interleukin-27 production" NARROW []
synonym: "positive regulation of IL-27 production" EXACT []
synonym: "stimulation of interleukin-27 production" NARROW []
synonym: "up regulation of interleukin-27 production" EXACT []
synonym: "up-regulation of interleukin-27 production" EXACT []
synonym: "upregulation of interleukin-27 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032671 ! regulation of interleukin-27 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032631 ! interleukin-27 production
relationship: positively_regulates GO:0032631 ! interleukin-27 production

[Term]
id: GO:0032752
name: positive regulation of interleukin-3 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-3 production." [GOC:mah]
synonym: "activation of interleukin-3 production" NARROW []
synonym: "positive regulation of IL-3 production" EXACT []
synonym: "stimulation of interleukin-3 production" NARROW []
synonym: "up regulation of interleukin-3 production" EXACT []
synonym: "up-regulation of interleukin-3 production" EXACT []
synonym: "upregulation of interleukin-3 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032672 ! regulation of interleukin-3 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032632 ! interleukin-3 production
relationship: positively_regulates GO:0032632 ! interleukin-3 production

[Term]
id: GO:0032753
name: positive regulation of interleukin-4 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-4 production." [GOC:mah]
synonym: "activation of interleukin-4 production" NARROW []
synonym: "positive regulation of IL-4 production" EXACT []
synonym: "stimulation of interleukin-4 production" NARROW []
synonym: "up regulation of interleukin-4 production" EXACT []
synonym: "up-regulation of interleukin-4 production" EXACT []
synonym: "upregulation of interleukin-4 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032673 ! regulation of interleukin-4 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032633 ! interleukin-4 production
relationship: positively_regulates GO:0032633 ! interleukin-4 production

[Term]
id: GO:0032754
name: positive regulation of interleukin-5 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-5 production." [GOC:mah]
synonym: "activation of interleukin-5 production" NARROW []
synonym: "positive regulation of IL-5 production" EXACT []
synonym: "stimulation of interleukin-5 production" NARROW []
synonym: "up regulation of interleukin-5 production" EXACT []
synonym: "up-regulation of interleukin-5 production" EXACT []
synonym: "upregulation of interleukin-5 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032674 ! regulation of interleukin-5 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032634 ! interleukin-5 production
relationship: positively_regulates GO:0032634 ! interleukin-5 production

[Term]
id: GO:0032755
name: positive regulation of interleukin-6 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-6 production." [GOC:mah]
synonym: "activation of interleukin-6 production" NARROW []
synonym: "positive regulation of IL-6 production" EXACT []
synonym: "stimulation of interleukin-6 production" NARROW []
synonym: "up regulation of interleukin-6 production" EXACT []
synonym: "up-regulation of interleukin-6 production" EXACT []
synonym: "upregulation of interleukin-6 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032675 ! regulation of interleukin-6 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032635 ! interleukin-6 production
relationship: positively_regulates GO:0032635 ! interleukin-6 production

[Term]
id: GO:0032756
name: positive regulation of interleukin-7 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-7 production." [GOC:mah]
synonym: "activation of interleukin-7 production" NARROW []
synonym: "positive regulation of IL-7 production" EXACT []
synonym: "stimulation of interleukin-7 production" NARROW []
synonym: "up regulation of interleukin-7 production" EXACT []
synonym: "up-regulation of interleukin-7 production" EXACT []
synonym: "upregulation of interleukin-7 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032676 ! regulation of interleukin-7 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032636 ! interleukin-7 production
relationship: positively_regulates GO:0032636 ! interleukin-7 production

[Term]
id: GO:0032757
name: positive regulation of interleukin-8 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-8 production." [GOC:mah]
synonym: "activation of interleukin-8 production" NARROW []
synonym: "positive regulation of IL-8 production" EXACT []
synonym: "stimulation of interleukin-8 production" NARROW []
synonym: "up regulation of interleukin-8 production" EXACT []
synonym: "up-regulation of interleukin-8 production" EXACT []
synonym: "upregulation of interleukin-8 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032677 ! regulation of interleukin-8 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032637 ! interleukin-8 production
relationship: positively_regulates GO:0032637 ! interleukin-8 production

[Term]
id: GO:0032758
name: positive regulation of interleukin-9 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-9 production." [GOC:mah]
synonym: "activation of interleukin-9 production" NARROW []
synonym: "positive regulation of IL-9 production" EXACT []
synonym: "stimulation of interleukin-9 production" NARROW []
synonym: "up regulation of interleukin-9 production" EXACT []
synonym: "up-regulation of interleukin-9 production" EXACT []
synonym: "upregulation of interleukin-9 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032678 ! regulation of interleukin-9 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032638 ! interleukin-9 production
relationship: positively_regulates GO:0032638 ! interleukin-9 production

[Term]
id: GO:0032759
name: positive regulation of TRAIL production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of TRAIL production." [GOC:mah]
synonym: "activation of TRAIL production" NARROW []
synonym: "stimulation of TRAIL production" NARROW []
synonym: "up regulation of TRAIL production" EXACT []
synonym: "up-regulation of TRAIL production" EXACT []
synonym: "upregulation of TRAIL production" EXACT []
is_a: GO:0032679 ! regulation of TRAIL production
is_a: GO:1903557 ! positive regulation of tumor necrosis factor superfamily cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032639 ! TRAIL production
relationship: positively_regulates GO:0032639 ! TRAIL production

[Term]
id: GO:0032760
name: positive regulation of tumor necrosis factor production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of tumor necrosis factor production." [GOC:mah]
comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF').
synonym: "activation of tumor necrosis factor production" NARROW []
synonym: "positive regulation of TNF production" EXACT []
synonym: "positive regulation of TNF-alpha production" EXACT []
synonym: "positive regulation of tumor necrosis factor-alpha production" EXACT []
synonym: "stimulation of tumor necrosis factor production" NARROW []
synonym: "up regulation of tumor necrosis factor production" EXACT []
synonym: "up-regulation of tumor necrosis factor production" EXACT []
synonym: "upregulation of tumor necrosis factor production" EXACT []
is_a: GO:0032680 ! regulation of tumor necrosis factor production
is_a: GO:1903557 ! positive regulation of tumor necrosis factor superfamily cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032640 ! tumor necrosis factor production
relationship: positively_regulates GO:0032640 ! tumor necrosis factor production

[Term]
id: GO:0032761
name: positive regulation of lymphotoxin A production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of lymphotoxin A production." [GOC:mah]
synonym: "activation of lymphotoxin A production" NARROW []
synonym: "positive regulation of LTA production" EXACT []
synonym: "positive regulation of lymphotoxin-alpha production" EXACT []
synonym: "positive regulation of TNF-beta production" EXACT []
synonym: "positive regulation of tumor necrosis factor-beta production" EXACT []
synonym: "stimulation of lymphotoxin A production" NARROW []
synonym: "up regulation of lymphotoxin A production" EXACT []
synonym: "up-regulation of lymphotoxin A production" EXACT []
synonym: "upregulation of lymphotoxin A production" EXACT []
is_a: GO:0032681 ! regulation of lymphotoxin A production
is_a: GO:1903557 ! positive regulation of tumor necrosis factor superfamily cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032641 ! lymphotoxin A production
relationship: positively_regulates GO:0032641 ! lymphotoxin A production

[Term]
id: GO:0032762
name: mast cell cytokine production
namespace: biological_process
def: "Any process that contributes to cytokine production by a mast cell." [GOC:mah]
is_a: GO:0061082 ! myeloid leukocyte cytokine production

[Term]
id: GO:0032763
name: regulation of mast cell cytokine production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of mast cell cytokine production." [GOC:mah]
is_a: GO:0002718 ! regulation of cytokine production involved in immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032762 ! mast cell cytokine production
relationship: regulates GO:0032762 ! mast cell cytokine production

[Term]
id: GO:0032764
name: negative regulation of mast cell cytokine production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell cytokine production." [GOC:mah]
synonym: "down regulation of mast cell cytokine production" EXACT []
synonym: "down-regulation of mast cell cytokine production" EXACT []
synonym: "downregulation of mast cell cytokine production" EXACT []
synonym: "inhibition of mast cell cytokine production" NARROW []
is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response
is_a: GO:0032763 ! regulation of mast cell cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032762 ! mast cell cytokine production
relationship: negatively_regulates GO:0032762 ! mast cell cytokine production

[Term]
id: GO:0032765
name: positive regulation of mast cell cytokine production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of mast cell cytokine production." [GOC:mah]
synonym: "activation of mast cell cytokine production" NARROW []
synonym: "stimulation of mast cell cytokine production" NARROW []
synonym: "up regulation of mast cell cytokine production" EXACT []
synonym: "up-regulation of mast cell cytokine production" EXACT []
synonym: "upregulation of mast cell cytokine production" EXACT []
is_a: GO:0032763 ! regulation of mast cell cytokine production
is_a: GO:0061081 ! positive regulation of myeloid leukocyte cytokine production involved in immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032762 ! mast cell cytokine production
relationship: positively_regulates GO:0032762 ! mast cell cytokine production

[Term]
id: GO:0032766
name: NHE3/E3KARP/ACTN4 complex
namespace: cellular_component
def: "A heterotrimeric protein complex formed by the association of NHE3, E3KARP and alpha-actinin upon an increase in calcium ion concentration; found in clusters localized on plasma membrane and in intracellular compartments." [PMID:11948184]
synonym: "NHE3/E3KARP/alpha-actinin complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0032767
name: copper-dependent protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of copper." [GOC:ecd, PMID:16884690]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0032768
name: regulation of monooxygenase activity
namespace: biological_process
def: "Any process that modulates the activity of a monooxygenase." [GOC:mah]
subset: gosubset_prok
is_a: GO:0051341 ! regulation of oxidoreductase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004497 ! monooxygenase activity
relationship: regulates GO:0004497 ! monooxygenase activity

[Term]
id: GO:0032769
name: negative regulation of monooxygenase activity
namespace: biological_process
def: "Any process that stops or reduces the activity of a monooxygenase." [GOC:mah]
synonym: "down regulation of monooxygenase activity" EXACT []
synonym: "down-regulation of monooxygenase activity" EXACT []
synonym: "downregulation of monooxygenase activity" EXACT []
synonym: "inhibition of monooxygenase activity" NARROW []
is_a: GO:0032768 ! regulation of monooxygenase activity
is_a: GO:0051354 ! negative regulation of oxidoreductase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004497 ! monooxygenase activity
relationship: negatively_regulates GO:0004497 ! monooxygenase activity

[Term]
id: GO:0032770
name: positive regulation of monooxygenase activity
namespace: biological_process
def: "Any process that activates or increases the activity of a monooxygenase." [GOC:mah]
synonym: "activation of monooxygenase activity" NARROW []
synonym: "stimulation of monooxygenase activity" NARROW []
synonym: "up regulation of monooxygenase activity" EXACT []
synonym: "up-regulation of monooxygenase activity" EXACT []
synonym: "upregulation of monooxygenase activity" EXACT []
is_a: GO:0032768 ! regulation of monooxygenase activity
is_a: GO:0051353 ! positive regulation of oxidoreductase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004497 ! monooxygenase activity
relationship: positively_regulates GO:0004497 ! monooxygenase activity

[Term]
id: GO:0032771
name: regulation of monophenol monooxygenase activity
namespace: biological_process
def: "Any process that modulates the activity of the enzyme monophenol monooxygenase. Monophenol monooxygenase catalyzes the reaction: L-tyrosine + L-DOPA + O2 = L-DOPA + DOPAquinone + H2O." [GOC:dph, GOC:mah, GOC:tb, PMID:2494997]
synonym: "regulation of monophenol oxygenase activity" EXACT [GOC:dph, GOC:tb]
is_a: GO:0032768 ! regulation of monooxygenase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004503 ! monophenol monooxygenase activity
relationship: regulates GO:0004503 ! monophenol monooxygenase activity

[Term]
id: GO:0032772
name: negative regulation of monophenol monooxygenase activity
namespace: biological_process
def: "Any process that stops or reduces the activity of the enzyme monophenol monooxygenase. Monophenol monooxygenase catalyzes the reaction: L-tyrosine + L-DOPA + O2 = L-DOPA + DOPAquinone + H2O." [GOC:dph, GOC:mah, GOC:tb]
synonym: "down regulation of monophenol oxygenase activity" EXACT []
synonym: "down-regulation of monophenol oxygenase activity" EXACT []
synonym: "downregulation of monophenol oxygenase activity" EXACT []
synonym: "inhibition of monophenol oxygenase activity" NARROW []
synonym: "negative regulation of monophenol oxygenase activity" EXACT [GOC:dph, GOC:tb, PMID:2494997]
is_a: GO:0032769 ! negative regulation of monooxygenase activity
is_a: GO:0032771 ! regulation of monophenol monooxygenase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004503 ! monophenol monooxygenase activity
relationship: negatively_regulates GO:0004503 ! monophenol monooxygenase activity

[Term]
id: GO:0032773
name: positive regulation of monophenol monooxygenase activity
namespace: biological_process
def: "Any process that activates or increases the activity of the enzyme monophenol oxygenase. Monophenol monooxygenase catalyzes the reaction: L-tyrosine + L-DOPA + O2 = L-DOPA + DOPAquinone + H2O." [GOC:dph, GOC:mah, GOC:tb, PMID:2494997]
synonym: "activation of monophenol oxygenase activity" NARROW []
synonym: "positive regulation of monophenol oxygenase activity" EXACT [GOC:dph, GOC:tb, PMID:2494997]
synonym: "stimulation of monophenol oxygenase activity" NARROW []
synonym: "up regulation of monophenol oxygenase activity" EXACT []
synonym: "up-regulation of monophenol oxygenase activity" EXACT []
synonym: "upregulation of monophenol oxygenase activity" EXACT []
is_a: GO:0032770 ! positive regulation of monooxygenase activity
is_a: GO:0032771 ! regulation of monophenol monooxygenase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004503 ! monophenol monooxygenase activity
relationship: positively_regulates GO:0004503 ! monophenol monooxygenase activity

[Term]
id: GO:0032774
name: RNA biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication." [GOC:mah, GOC:txnOH]
comment: Note that, in some cases, viral RNA replication and viral transcription from RNA actually refer to the same process, but may be called differently depending on the focus of a specific research study.
synonym: "RNA anabolism" EXACT []
synonym: "RNA biosynthesis" EXACT []
synonym: "RNA formation" EXACT []
synonym: "RNA synthesis" EXACT []
is_a: GO:0009059 ! macromolecule biosynthetic process
is_a: GO:0016070 ! RNA metabolic process
is_a: GO:0034654 ! nucleobase-containing compound biosynthetic process

[Term]
id: GO:0032775
name: DNA methylation on adenine
namespace: biological_process
def: "The covalent transfer of a methyl group to N-6 of adenine in a DNA molecule." [GOC:pf]
synonym: "adenine methylation" RELATED []
is_a: GO:0006306 ! DNA methylation

[Term]
id: GO:0032776
name: DNA methylation on cytosine
namespace: biological_process
def: "The covalent transfer of a methyl group to C-5 or N-4 of cytosine in a DNA molecule." [GOC:pf]
synonym: "cytosine methylation" BROAD []
is_a: GO:0006306 ! DNA methylation

[Term]
id: GO:0032777
name: Piccolo NuA4 histone acetyltransferase complex
namespace: cellular_component
def: "A heterotrimeric H4/H2A histone acetyltransferase complex with a substrate preference of chromatin over free histones. It contains a subset of the proteins found in the larger NuA4 histone acetyltransferase complex; for example, the S. cerevisiae complex contains Esa1p, Yng2p, and Epl1p." [GOC:rb, PMID:12782659, PMID:15964809]
is_a: GO:0035267 ! NuA4 histone acetyltransferase complex

[Term]
id: GO:0032778
name: cobalt-transporting ATPase activity
namespace: molecular_function
alt_id: GO:0015632
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cobalt(out) = ADP + phosphate + cobalt(in)." [GOC:mlg, GOC:mtg_transport, ISBN:0815340729]
synonym: "cobalt ABC transporter" RELATED []
synonym: "cobalt porter activity" RELATED []
synonym: "cobalt transporting ATPase activity" EXACT []
xref: RHEA:32782
is_a: GO:0015087 ! cobalt ion transmembrane transporter activity
is_a: GO:0019829 ! cation-transporting ATPase activity

[Term]
id: GO:0032780
name: negative regulation of ATPase activity
namespace: biological_process
def: "Any process that stops or reduces the rate of ATP hydrolysis by an ATPase." [GOC:mah]
synonym: "down regulation of ATPase activity" EXACT []
synonym: "down-regulation of ATPase activity" EXACT []
synonym: "downregulation of ATPase activity" EXACT []
synonym: "inhibition of ATPase activity" NARROW []
synonym: "negative regulation of adenosinetriphosphatase activity" EXACT []
is_a: GO:0043462 ! regulation of ATPase activity
is_a: GO:0051346 ! negative regulation of hydrolase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016887 ! ATPase activity
relationship: negatively_regulates GO:0016887 ! ATPase activity

[Term]
id: GO:0032781
name: positive regulation of ATPase activity
namespace: biological_process
def: "Any process that activates or increases the rate of ATP hydrolysis by an ATPase." [GOC:mah]
synonym: "activation of ATPase activity" NARROW []
synonym: "positive regulation of adenosinetriphosphatase activity" EXACT []
synonym: "stimulation of ATPase activity" NARROW []
synonym: "up regulation of ATPase activity" EXACT []
synonym: "up-regulation of ATPase activity" EXACT []
synonym: "upregulation of ATPase activity" EXACT []
is_a: GO:0043462 ! regulation of ATPase activity
is_a: GO:0051345 ! positive regulation of hydrolase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016887 ! ATPase activity
relationship: positively_regulates GO:0016887 ! ATPase activity

[Term]
id: GO:0032782
name: bile acid secretion
namespace: biological_process
def: "The regulated release of bile acid, composed of any of a group of steroid carboxylic acids occurring in bile, by a cell or a tissue." [GOC:ecd]
is_a: GO:0015721 ! bile acid and bile salt transport
is_a: GO:0046717 ! acid secretion

[Term]
id: GO:0032783
name: ELL-EAF complex
namespace: cellular_component
def: "A heterodimeric protein complex that acts as an RNA polymerase II elongation factor; the complex is conserved from yeast to humans, and is present in S. pombe, but absent from S. cerevisiae." [PMID:17150956]
is_a: GO:0008023 ! transcription elongation factor complex

[Term]
id: GO:0032784
name: regulation of DNA-templated transcription, elongation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase." [GOC:mah, GOC:txnOH]
synonym: "regulation of DNA-dependent transcription, elongation" EXACT [GOC:txnOH]
synonym: "regulation of RNA elongation" BROAD []
synonym: "regulation of transcription elongation, DNA-dependent" EXACT [GOC:jh2]
synonym: "regulation of transcriptional elongation" BROAD []
synonym: "transcription elongation regulator activity" RELATED []
is_a: GO:0006355 ! regulation of transcription, DNA-templated
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006354 ! DNA-templated transcription, elongation
relationship: regulates GO:0006354 ! DNA-templated transcription, elongation

[Term]
id: GO:0032785
name: negative regulation of DNA-templated transcription, elongation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase." [GOC:mah, GOC:txnOH]
synonym: "down regulation of RNA elongation" BROAD []
synonym: "down-regulation of RNA elongation" BROAD []
synonym: "downregulation of RNA elongation" BROAD []
synonym: "inhibition of RNA elongation" BROAD []
synonym: "negative regulation of DNA-dependent transcription, elongation" EXACT [GOC:txnOH]
synonym: "negative regulation of transcription elongation" BROAD []
synonym: "negative regulation of transcription elongation, DNA-dependent" EXACT [GOC:jh2]
synonym: "negative regulation of transcriptional elongation" BROAD []
synonym: "negative transcription elongation regulator activity" RELATED []
is_a: GO:0032784 ! regulation of DNA-templated transcription, elongation
is_a: GO:0045892 ! negative regulation of transcription, DNA-templated
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006354 ! DNA-templated transcription, elongation
relationship: negatively_regulates GO:0006354 ! DNA-templated transcription, elongation

[Term]
id: GO:0032786
name: positive regulation of DNA-templated transcription, elongation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase." [GOC:mah, GOC:txnOH]
synonym: "activation of RNA elongation" BROAD []
synonym: "positive regulation of DNA-dependent transcription, elongation" EXACT [GOC:txnOH]
synonym: "positive regulation of transcription elongation" BROAD []
synonym: "positive regulation of transcription elongation, DNA-dependent" EXACT [GOC:jh2]
synonym: "positive regulation of transcriptional elongation" BROAD []
synonym: "positive transcription elongation regulator activity" RELATED []
synonym: "stimulation of RNA elongation" BROAD []
synonym: "up regulation of RNA elongation" BROAD []
synonym: "up-regulation of RNA elongation" BROAD []
synonym: "upregulation of RNA elongation" BROAD []
is_a: GO:0032784 ! regulation of DNA-templated transcription, elongation
is_a: GO:0045893 ! positive regulation of transcription, DNA-templated
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006354 ! DNA-templated transcription, elongation
relationship: positively_regulates GO:0006354 ! DNA-templated transcription, elongation

[Term]
id: GO:0032787
name: monocarboxylic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-)." [GOC:vk]
subset: goslim_yeast
subset: gosubset_prok
synonym: "monocarboxylate metabolic process" EXACT []
synonym: "monocarboxylic acid metabolism" EXACT []
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0032788
name: saturated monocarboxylic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving saturated monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-) and fully saturated C-C bonds." [GOC:mah, GOC:vk]
synonym: "saturated monocarboxylate metabolic process" EXACT []
synonym: "saturated monocarboxylic acid metabolism" EXACT []
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0032789
name: unsaturated monocarboxylic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving unsaturated monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-) and one or more unsaturated C-C bonds." [GOC:mah, GOC:vk]
synonym: "unsaturated monocarboxylate metabolic process" EXACT []
synonym: "unsaturated monocarboxylic acid metabolism" EXACT []
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0032790
name: ribosome disassembly
namespace: biological_process
def: "The disaggregation of a ribosome into its constituent components; includes the dissociation of ribosomal subunits." [GOC:mah, GOC:vk]
synonym: "ribosome dissociation factor" RELATED []
synonym: "ribosome recycling" NARROW [GOC:db, PMID:9463391]
is_a: GO:0032988 ! ribonucleoprotein complex disassembly
is_a: GO:1903008 ! organelle disassembly

[Term]
id: GO:0032791
name: lead ion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with lead (Pb) ions." [GOC:mah]
subset: gosubset_prok
is_a: GO:0046872 ! metal ion binding

[Term]
id: GO:0032792
name: negative regulation of CREB transcription factor activity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor CREB." [GOC:dph, GOC:ecd, GOC:tb]
synonym: "CREB inhibitor" RELATED []
synonym: "inhibition of CREB transcription factor" EXACT [GOC:dph, GOC:tb]
is_a: GO:0043433 ! negative regulation of sequence-specific DNA binding transcription factor activity

[Term]
id: GO:0032793
name: positive regulation of CREB transcription factor activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of activity of the transcription factor CREB." [GOC:dph, GOC:ecd, GOC:tb]
synonym: "activation of CREB" EXACT []
synonym: "activation of CREB transcription factor" EXACT [GOC:dph, GOC:tb]
synonym: "CREB activator" RELATED []
is_a: GO:0051091 ! positive regulation of sequence-specific DNA binding transcription factor activity

[Term]
id: GO:0032794
name: GTPase activating protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a GTPase activating protein." [GOC:nln]
synonym: "GAP binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0032795
name: heterotrimeric G-protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a heterotrimeric G-protein." [GOC:nln]
is_a: GO:0032403 ! protein complex binding

[Term]
id: GO:0032796
name: uropod organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a uropod, a rigid membrane projection with related cytoskeletal components at the trailing edge of a lymphocyte or other cell in the process of migrating or being activated." [GOC:add, ISBN:0781735149, PMID:12714569, PMID:12787750]
synonym: "uropod organisation" EXACT [GOC:mah]
synonym: "uropod organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0030030 ! cell projection organization

[Term]
id: GO:0032797
name: SMN complex
namespace: cellular_component
def: "A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus." [PMID:16434402, PMID:17023415]
comment: Note that a larger complex containing Sm proteins and other subunits is also sometimes referred to as the 'SMN complex'. The larger complex is represented by 'SMN-Sm protein complex ; GO:0034719'.
synonym: "SMN core complex" EXACT []
synonym: "survival motor neuron complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0032798
name: Swi5-Sfr1 complex
namespace: cellular_component
def: "A conserved DNA recombinase mediator complex that contains two Swi5 monomers and one Sfr1 monomer in Schizosaccharomyces, or orthologs thereof (e.g. Sae3p and Mei5p in Saccharomyces)." [PMID:15620352, PMID:16921379]
comment: Note that this term refers to Schizosaccharomyces pombe Swi5, which should not be confused with the unrelated Saccharomyces Swi5p.
synonym: "Sae3-Mei5 complex" EXACT [GOC:elh, GOC:vw]
synonym: "Swi5 complex" BROAD []
is_a: GO:0033061 ! DNA recombinase mediator complex
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000790 ! nuclear chromatin

[Term]
id: GO:0032799
name: low-density lipoprotein receptor particle metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving low-density lipoprotein receptors." [GOC:vk]
synonym: "LDL receptor metabolic process" EXACT []
synonym: "low-density lipoprotein receptor metabolic process" EXACT [GOC:bf, GOC:dph]
synonym: "low-density lipoprotein receptor metabolism" EXACT []
is_a: GO:0043112 ! receptor metabolic process

[Term]
id: GO:0032800
name: receptor biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:mah]
synonym: "receptor anabolism" EXACT []
synonym: "receptor biosynthesis" EXACT []
synonym: "receptor formation" EXACT []
synonym: "receptor synthesis" EXACT []
is_a: GO:0009059 ! macromolecule biosynthetic process
is_a: GO:0043112 ! receptor metabolic process

[Term]
id: GO:0032801
name: receptor catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:mah]
synonym: "receptor breakdown" EXACT []
synonym: "receptor catabolism" EXACT []
synonym: "receptor degradation" EXACT []
is_a: GO:0009057 ! macromolecule catabolic process
is_a: GO:0043112 ! receptor metabolic process
is_a: GO:0044248 ! cellular catabolic process

[Term]
id: GO:0032802
name: low-density lipoprotein particle receptor catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a low-density lipoprotein particle receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:mah]
synonym: "LDL receptor breakdown" EXACT []
synonym: "LDL receptor catabolic process" EXACT []
synonym: "LDL receptor catabolism" RELATED []
synonym: "LDL receptor degradation" EXACT []
synonym: "low-density lipoprotein receptor breakdown" EXACT []
synonym: "low-density lipoprotein receptor catabolic process" EXACT [GOC:dph]
synonym: "low-density lipoprotein receptor catabolism" EXACT []
synonym: "low-density lipoprotein receptor degradation" EXACT []
is_a: GO:0032799 ! low-density lipoprotein receptor particle metabolic process
is_a: GO:0032801 ! receptor catabolic process
is_a: GO:0044257 ! cellular protein catabolic process

[Term]
id: GO:0032803
name: regulation of low-density lipoprotein particle receptor catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of low-density lipoprotein particle receptors." [GOC:mah]
synonym: "regulation of LDLr catabolic process" EXACT []
synonym: "regulation of LDLr catabolism" EXACT []
synonym: "regulation of low-density lipoprotein receptor breakdown" EXACT []
synonym: "regulation of low-density lipoprotein receptor catabolic process" EXACT [GOC:bf, GOC:dph]
synonym: "regulation of low-density lipoprotein receptor catabolism" EXACT []
synonym: "regulation of low-density lipoprotein receptor degradation" EXACT []
is_a: GO:1903362 ! regulation of cellular protein catabolic process
is_a: GO:2000644 ! regulation of receptor catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032802 ! low-density lipoprotein particle receptor catabolic process
relationship: regulates GO:0032802 ! low-density lipoprotein particle receptor catabolic process

[Term]
id: GO:0032804
name: negative regulation of low-density lipoprotein particle receptor catabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of low-density lipoprotein receptors." [GOC:mah]
synonym: "down regulation of low-density lipoprotein receptor catabolic process" EXACT []
synonym: "down-regulation of low-density lipoprotein receptor catabolic process" EXACT []
synonym: "downregulation of low-density lipoprotein receptor catabolic process" EXACT []
synonym: "inhibition of low-density lipoprotein receptor catabolic process" NARROW []
synonym: "negative regulation of low-density lipoprotein receptor breakdown" EXACT []
synonym: "negative regulation of low-density lipoprotein receptor catabolic process" EXACT [GOC:dph]
synonym: "negative regulation of low-density lipoprotein receptor catabolism" EXACT []
synonym: "negative regulation of low-density lipoprotein receptor degradation" EXACT []
is_a: GO:0032803 ! regulation of low-density lipoprotein particle receptor catabolic process
is_a: GO:1903363 ! negative regulation of cellular protein catabolic process
is_a: GO:2000645 ! negative regulation of receptor catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032802 ! low-density lipoprotein particle receptor catabolic process
relationship: negatively_regulates GO:0032802 ! low-density lipoprotein particle receptor catabolic process

[Term]
id: GO:0032805
name: positive regulation of low-density lipoprotein particle receptor catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of low-density lipoprotein particle receptors." [GOC:mah]
synonym: "activation of low-density lipoprotein receptor catabolic process" NARROW []
synonym: "positive regulation of low-density lipoprotein receptor breakdown" EXACT []
synonym: "positive regulation of low-density lipoprotein receptor catabolic process" EXACT [GOC:bf, GOC:dph]
synonym: "positive regulation of low-density lipoprotein receptor catabolism" EXACT []
synonym: "positive regulation of low-density lipoprotein receptor degradation" EXACT []
synonym: "stimulation of low-density lipoprotein receptor catabolic process" NARROW []
synonym: "up regulation of low-density lipoprotein receptor catabolic process" EXACT []
synonym: "up-regulation of low-density lipoprotein receptor catabolic process" EXACT []
synonym: "upregulation of low-density lipoprotein receptor catabolic process" EXACT []
is_a: GO:0032803 ! regulation of low-density lipoprotein particle receptor catabolic process
is_a: GO:1903364 ! positive regulation of cellular protein catabolic process
is_a: GO:2000646 ! positive regulation of receptor catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032802 ! low-density lipoprotein particle receptor catabolic process
relationship: positively_regulates GO:0032802 ! low-density lipoprotein particle receptor catabolic process

[Term]
id: GO:0032806
name: carboxy-terminal domain protein kinase complex
namespace: cellular_component
def: "A protein complex that phosphorylates amino acid residues of RNA polymerase II C-terminal domain repeats; phosphorylation occurs mainly on Ser2 and Ser5." [PMID:15047695, PMID:16721054, PMID:17079683]
synonym: "CTDK complex" EXACT []
is_a: GO:0044428 ! nuclear part
is_a: GO:1902554 ! serine/threonine protein kinase complex

[Term]
id: GO:0032807
name: DNA ligase IV complex
namespace: cellular_component
def: "A eukaryotically conserved protein complex that contains DNA ligase IV and is involved in DNA repair by non-homologous end joining; in addition to the ligase, the complex also contains XRCC4 or a homolog, e.g. Saccharomyces Lif1p." [PMID:16314503]
synonym: "DNA ligase IV-XRCC4 complex" EXACT [GOC:mah]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0032808
name: lacrimal gland development
namespace: biological_process
def: "The process whose specific outcome is the progression of the lacrimal gland over time, from its formation to the mature structure. The lacrimal gland produces secretions that lubricate and protect the cornea of the eye." [GOC:ln]
is_a: GO:0048732 ! gland development
relationship: part_of GO:0035272 ! exocrine system development

[Term]
id: GO:0032809
name: neuronal cell body membrane
namespace: cellular_component
def: "The plasma membrane of a neuron cell body - excludes the plasma membrane of cell projections such as axons and dendrites." [GOC:jl]
synonym: "neuron cell body membrane" EXACT []
synonym: "neuronal cell soma membrane" EXACT []
is_a: GO:0044298 ! cell body membrane
is_a: GO:0097458 ! neuron part
relationship: part_of GO:0043025 ! neuronal cell body

[Term]
id: GO:0032810
name: sterol response element binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the sterol response element (SRE), a nonpalindromic sequence found in the promoters of genes involved in lipid metabolism." [GOC:vk, PMID:11994399]
comment: Note that as agreed during the transcription overhaul, terms specifying binding to specific transcription regulatory motifs are no longer being created. The level of specificity GO has decided to go to is the "core promoter", "core promoter proximal region" and "enhancer". To capture more detail, please consider using column 16.
synonym: "SRE binding" EXACT []
is_a: GO:0044212 ! transcription regulatory region DNA binding

[Term]
id: GO:0032811
name: negative regulation of epinephrine secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of epinephrine." [GOC:vk]
synonym: "down regulation of epinephrine secretion" EXACT []
synonym: "down-regulation of epinephrine secretion" EXACT []
synonym: "downregulation of epinephrine secretion" EXACT []
synonym: "inhibition of epinephrine secretion" NARROW []
synonym: "negative regulation of adrenaline secretion" EXACT []
is_a: GO:0014060 ! regulation of epinephrine secretion
is_a: GO:0033604 ! negative regulation of catecholamine secretion
is_a: GO:0046888 ! negative regulation of hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048242 ! epinephrine secretion
relationship: negatively_regulates GO:0048242 ! epinephrine secretion

[Term]
id: GO:0032812
name: positive regulation of epinephrine secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of epinephrine." [GOC:vk]
synonym: "activation of epinephrine secretion" NARROW []
synonym: "positive regulation of adrenaline secretion" EXACT []
synonym: "stimulation of epinephrine secretion" NARROW []
synonym: "up regulation of epinephrine secretion" EXACT []
synonym: "up-regulation of epinephrine secretion" EXACT []
synonym: "upregulation of epinephrine secretion" EXACT []
is_a: GO:0014060 ! regulation of epinephrine secretion
is_a: GO:0033605 ! positive regulation of catecholamine secretion
is_a: GO:0046887 ! positive regulation of hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048242 ! epinephrine secretion
relationship: positively_regulates GO:0048242 ! epinephrine secretion

[Term]
id: GO:0032813
name: tumor necrosis factor receptor superfamily binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any member of the tumor necrosis factor receptor superfamily." [GOC:add]
synonym: "TNF receptor superfamily binding" EXACT []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0032814
name: regulation of natural killer cell activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of natural killer cell activation." [GOC:mah]
synonym: "regulation of NK cell activation" EXACT []
is_a: GO:0051249 ! regulation of lymphocyte activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030101 ! natural killer cell activation
relationship: regulates GO:0030101 ! natural killer cell activation

[Term]
id: GO:0032815
name: negative regulation of natural killer cell activation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell activation." [GOC:mah]
synonym: "down regulation of natural killer cell activation" EXACT []
synonym: "down-regulation of natural killer cell activation" EXACT []
synonym: "downregulation of natural killer cell activation" EXACT []
synonym: "inhibition of natural killer cell activation" NARROW []
synonym: "negative regulation of NK cell activation" EXACT []
is_a: GO:0032814 ! regulation of natural killer cell activation
is_a: GO:0051250 ! negative regulation of lymphocyte activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030101 ! natural killer cell activation
relationship: negatively_regulates GO:0030101 ! natural killer cell activation

[Term]
id: GO:0032816
name: positive regulation of natural killer cell activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of natural killer cell activation." [GOC:mah]
synonym: "activation of natural killer cell activation" NARROW []
synonym: "positive regulation of NK cell activation" EXACT []
synonym: "stimulation of natural killer cell activation" NARROW []
synonym: "up regulation of natural killer cell activation" EXACT []
synonym: "up-regulation of natural killer cell activation" EXACT []
synonym: "upregulation of natural killer cell activation" EXACT []
is_a: GO:0032814 ! regulation of natural killer cell activation
is_a: GO:0051251 ! positive regulation of lymphocyte activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030101 ! natural killer cell activation
relationship: positively_regulates GO:0030101 ! natural killer cell activation

[Term]
id: GO:0032817
name: regulation of natural killer cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of natural killer cell proliferation." [GOC:mah]
synonym: "regulation of NK cell proliferation" EXACT []
is_a: GO:0032814 ! regulation of natural killer cell activation
is_a: GO:0050670 ! regulation of lymphocyte proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001787 ! natural killer cell proliferation
relationship: regulates GO:0001787 ! natural killer cell proliferation

[Term]
id: GO:0032818
name: negative regulation of natural killer cell proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell proliferation." [GOC:mah]
synonym: "down regulation of natural killer cell proliferation" EXACT []
synonym: "down-regulation of natural killer cell proliferation" EXACT []
synonym: "downregulation of natural killer cell proliferation" EXACT []
synonym: "inhibition of natural killer cell proliferation" NARROW []
synonym: "negative regulation of NK cell proliferation" EXACT []
is_a: GO:0032815 ! negative regulation of natural killer cell activation
is_a: GO:0032817 ! regulation of natural killer cell proliferation
is_a: GO:0050672 ! negative regulation of lymphocyte proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001787 ! natural killer cell proliferation
relationship: negatively_regulates GO:0001787 ! natural killer cell proliferation

[Term]
id: GO:0032819
name: positive regulation of natural killer cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of natural killer cell proliferation." [GOC:mah]
synonym: "activation of natural killer cell proliferation" NARROW []
synonym: "positive regulation of NK cell proliferation" EXACT []
synonym: "stimulation of natural killer cell proliferation" NARROW []
synonym: "up regulation of natural killer cell proliferation" EXACT []
synonym: "up-regulation of natural killer cell proliferation" EXACT []
synonym: "upregulation of natural killer cell proliferation" EXACT []
is_a: GO:0032816 ! positive regulation of natural killer cell activation
is_a: GO:0032817 ! regulation of natural killer cell proliferation
is_a: GO:0050671 ! positive regulation of lymphocyte proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001787 ! natural killer cell proliferation
relationship: positively_regulates GO:0001787 ! natural killer cell proliferation

[Term]
id: GO:0032820
name: regulation of natural killer cell proliferation involved in immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of natural killer cell proliferation as part of an immune response." [GOC:mah]
synonym: "regulation of natural killer cell proliferation during immune response" RELATED [GOC:tb]
synonym: "regulation of NK cell proliferation during immune response" RELATED []
is_a: GO:0002697 ! regulation of immune effector process
is_a: GO:0032817 ! regulation of natural killer cell proliferation
is_a: GO:0050776 ! regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002324 ! natural killer cell proliferation involved in immune response
relationship: regulates GO:0002324 ! natural killer cell proliferation involved in immune response

[Term]
id: GO:0032821
name: negative regulation of natural killer cell proliferation involved in immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell proliferation as part of an immune response." [GOC:mah]
synonym: "down regulation of natural killer cell proliferation during immune response" RELATED []
synonym: "down-regulation of natural killer cell proliferation during immune response" RELATED []
synonym: "downregulation of natural killer cell proliferation during immune response" RELATED []
synonym: "inhibition of natural killer cell proliferation during immune response" NARROW []
synonym: "negative regulation of natural killer cell proliferation during immune response" RELATED [GOC:tb]
synonym: "negative regulation of NK cell proliferation during immune response" RELATED []
is_a: GO:0002698 ! negative regulation of immune effector process
is_a: GO:0032818 ! negative regulation of natural killer cell proliferation
is_a: GO:0032820 ! regulation of natural killer cell proliferation involved in immune response
is_a: GO:0050777 ! negative regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002324 ! natural killer cell proliferation involved in immune response
relationship: negatively_regulates GO:0002324 ! natural killer cell proliferation involved in immune response

[Term]
id: GO:0032822
name: positive regulation of natural killer cell proliferation involved in immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of natural killer cell proliferation as part of an immune response." [GOC:mah]
synonym: "activation of natural killer cell proliferation during immune response" NARROW []
synonym: "positive regulation of natural killer cell proliferation during immune response" RELATED [GOC:tb]
synonym: "positive regulation of NK cell proliferation during immune response" RELATED []
synonym: "stimulation of natural killer cell proliferation during immune response" NARROW []
synonym: "up regulation of natural killer cell proliferation during immune response" RELATED []
synonym: "up-regulation of natural killer cell proliferation during immune response" RELATED []
synonym: "upregulation of natural killer cell proliferation during immune response" RELATED []
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0032819 ! positive regulation of natural killer cell proliferation
is_a: GO:0032820 ! regulation of natural killer cell proliferation involved in immune response
is_a: GO:0050778 ! positive regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002324 ! natural killer cell proliferation involved in immune response
relationship: positively_regulates GO:0002324 ! natural killer cell proliferation involved in immune response

[Term]
id: GO:0032823
name: regulation of natural killer cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of natural killer cell differentiation." [GOC:mah]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "regulation of natural killer cell development" RELATED [GOC:add]
synonym: "regulation of NK cell differentiation" EXACT []
is_a: GO:0032814 ! regulation of natural killer cell activation
is_a: GO:0045619 ! regulation of lymphocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001779 ! natural killer cell differentiation
relationship: regulates GO:0001779 ! natural killer cell differentiation

[Term]
id: GO:0032824
name: negative regulation of natural killer cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell differentiation." [GOC:mah]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "down regulation of natural killer cell differentiation" EXACT []
synonym: "down-regulation of natural killer cell differentiation" EXACT []
synonym: "downregulation of natural killer cell differentiation" EXACT []
synonym: "inhibition of natural killer cell differentiation" NARROW []
synonym: "negative regulation of natural killer cell development" RELATED [GOC:add]
synonym: "negative regulation of NK cell differentiation" EXACT []
is_a: GO:0032815 ! negative regulation of natural killer cell activation
is_a: GO:0032823 ! regulation of natural killer cell differentiation
is_a: GO:0045620 ! negative regulation of lymphocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001779 ! natural killer cell differentiation
relationship: negatively_regulates GO:0001779 ! natural killer cell differentiation

[Term]
id: GO:0032825
name: positive regulation of natural killer cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of natural killer cell differentiation." [GOC:mah]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "activation of natural killer cell differentiation" NARROW []
synonym: "positive regulation of natural killer cell development" RELATED [GOC:add]
synonym: "positive regulation of NK cell differentiation" EXACT []
synonym: "stimulation of natural killer cell differentiation" NARROW []
synonym: "up regulation of natural killer cell differentiation" EXACT []
synonym: "up-regulation of natural killer cell differentiation" EXACT []
synonym: "upregulation of natural killer cell differentiation" EXACT []
is_a: GO:0032816 ! positive regulation of natural killer cell activation
is_a: GO:0032823 ! regulation of natural killer cell differentiation
is_a: GO:0045621 ! positive regulation of lymphocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001779 ! natural killer cell differentiation
relationship: positively_regulates GO:0001779 ! natural killer cell differentiation

[Term]
id: GO:0032826
name: regulation of natural killer cell differentiation involved in immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of natural killer cell differentiation as part of an immune response." [GOC:mah]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "regulation of natural killer cell development involved in immune response" RELATED [GOC:add]
synonym: "regulation of natural killer cell differentiation during immune response" RELATED [GOC:tb]
synonym: "regulation of NK cell differentiation during immune response" RELATED []
is_a: GO:0002697 ! regulation of immune effector process
is_a: GO:0032823 ! regulation of natural killer cell differentiation
is_a: GO:0050776 ! regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002325 ! natural killer cell differentiation involved in immune response
relationship: regulates GO:0002325 ! natural killer cell differentiation involved in immune response

[Term]
id: GO:0032827
name: negative regulation of natural killer cell differentiation involved in immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell differentiation as part of an immune response." [GOC:mah]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "down regulation of natural killer cell differentiation during immune response" RELATED []
synonym: "down-regulation of natural killer cell differentiation during immune response" RELATED []
synonym: "downregulation of natural killer cell differentiation during immune response" RELATED []
synonym: "inhibition of natural killer cell differentiation during immune response" NARROW []
synonym: "negative regulation of natural killer cell development involved in immune response" RELATED [GOC:add]
synonym: "negative regulation of natural killer cell differentiation during immune response" RELATED [GOC:tb]
synonym: "negative regulation of NK cell differentiation during immune response" RELATED []
is_a: GO:0002698 ! negative regulation of immune effector process
is_a: GO:0032824 ! negative regulation of natural killer cell differentiation
is_a: GO:0032826 ! regulation of natural killer cell differentiation involved in immune response
is_a: GO:0050777 ! negative regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002325 ! natural killer cell differentiation involved in immune response
relationship: negatively_regulates GO:0002325 ! natural killer cell differentiation involved in immune response

[Term]
id: GO:0032828
name: positive regulation of natural killer cell differentiation involved in immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of natural killer cell differentiation as part of an immune response." [GOC:mah]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "activation of natural killer cell differentiation during immune response" NARROW []
synonym: "positive regulation of natural killer cell development involved in immune response" RELATED [GOC:add]
synonym: "positive regulation of natural killer cell differentiation during immune response" RELATED [GOC:tb]
synonym: "positive regulation of NK cell differentiation during immune response" RELATED []
synonym: "stimulation of natural killer cell differentiation during immune response" NARROW []
synonym: "up regulation of natural killer cell differentiation during immune response" RELATED []
synonym: "up-regulation of natural killer cell differentiation during immune response" RELATED []
synonym: "upregulation of natural killer cell differentiation during immune response" RELATED []
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0032825 ! positive regulation of natural killer cell differentiation
is_a: GO:0032826 ! regulation of natural killer cell differentiation involved in immune response
is_a: GO:0050778 ! positive regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002325 ! natural killer cell differentiation involved in immune response
relationship: positively_regulates GO:0002325 ! natural killer cell differentiation involved in immune response

[Term]
id: GO:0032829
name: regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells." [GOC:mah]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development" RELATED [GOC:add]
synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation" EXACT []
synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation" EXACT []
synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation" EXACT []
is_a: GO:0043370 ! regulation of CD4-positive, alpha-beta T cell differentiation
is_a: GO:0045589 ! regulation of regulatory T cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
relationship: regulates GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

[Term]
id: GO:0032830
name: negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells." [GOC:mah]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "down regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT []
synonym: "down-regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT []
synonym: "downregulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT []
synonym: "inhibition of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" NARROW []
synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development" RELATED [GOC:add]
synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation" EXACT []
synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation" EXACT []
synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation" EXACT []
is_a: GO:0032829 ! regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
is_a: GO:0043371 ! negative regulation of CD4-positive, alpha-beta T cell differentiation
is_a: GO:0045590 ! negative regulation of regulatory T cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
relationship: negatively_regulates GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

[Term]
id: GO:0032831
name: positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells." [GOC:mah]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "activation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" NARROW []
synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development" RELATED [GOC:add]
synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation" EXACT []
synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation" EXACT []
synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation" EXACT []
synonym: "stimulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" NARROW []
synonym: "up regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT []
synonym: "up-regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT []
synonym: "upregulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT []
is_a: GO:0032829 ! regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
is_a: GO:0043372 ! positive regulation of CD4-positive, alpha-beta T cell differentiation
is_a: GO:0045591 ! positive regulation of regulatory T cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
relationship: positively_regulates GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

[Term]
id: GO:0032832
name: regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells as part of an immune response." [GOC:mah]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development involved in immune response" RELATED [GOC:add]
synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [GOC:tb]
synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response" RELATED []
synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response" RELATED []
synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response" RELATED []
is_a: GO:0002697 ! regulation of immune effector process
is_a: GO:0032829 ! regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
is_a: GO:0050776 ! regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002298 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response
relationship: regulates GO:0002298 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response

[Term]
id: GO:0032833
name: negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells as part of an immune response." [GOC:mah]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "down regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED []
synonym: "down-regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED []
synonym: "downregulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED []
synonym: "inhibition of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" NARROW []
synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development involved in immune response" RELATED [GOC:add]
synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [GOC:tb]
synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response" RELATED []
synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response" RELATED []
synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response" RELATED []
is_a: GO:0002698 ! negative regulation of immune effector process
is_a: GO:0032830 ! negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
is_a: GO:0032832 ! regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response
is_a: GO:0050777 ! negative regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002298 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response
relationship: negatively_regulates GO:0002298 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response

[Term]
id: GO:0032834
name: positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells as part of an immune response." [GOC:mah]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "activation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" NARROW []
synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development involved in immune response" RELATED [GOC:add]
synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [GOC:tb]
synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response" RELATED []
synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response" RELATED []
synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response" RELATED []
synonym: "stimulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" NARROW []
synonym: "up regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED []
synonym: "up-regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED []
synonym: "upregulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED []
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0032831 ! positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
is_a: GO:0032832 ! regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response
is_a: GO:0050778 ! positive regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002298 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response
relationship: positively_regulates GO:0002298 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response

[Term]
id: GO:0032835
name: glomerulus development
namespace: biological_process
def: "The progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the vertebrate kidney. The glomerulus is part of the nephron and is restricted to one body segment." [GOC:mah, GOC:mtg_kidney_jan10]
synonym: "glomerular development" EXACT []
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0072006 ! nephron development

[Term]
id: GO:0032836
name: glomerular basement membrane development
namespace: biological_process
def: "The process whose specific outcome is the progression of the glomerular basement membrane over time, from its formation to the mature structure. The glomerular basement membrane is the basal laminal portion of the glomerulus which performs the actual filtration." [GOC:sr]
is_a: GO:0030198 ! extracellular matrix organization
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0032835 ! glomerulus development

[Term]
id: GO:0032837
name: distributive segregation
namespace: biological_process
def: "The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during a normally chiasmate meiosis under the condition that chiasma have not occurred between a particular pair of homologs. Distributive segregation is a \"backup\" mechanism to ensure the segregation of homologs that have failed to cross over - either as a consequence of mutation or not, as, for example, the 4th chromosome of Drosophila melanogaster (which never exchanges, presumably due to its small size) - but nevertheless segregate normally." [GOC:expert_rsh, GOC:ma, GOC:sart]
is_a: GO:0045132 ! meiotic chromosome segregation

[Term]
id: GO:0032838
name: cell projection cytoplasm
namespace: cellular_component
def: "All of the contents of a cell projection, excluding the plasma membrane surrounding the projection." [GOC:mah]
is_a: GO:0044463 ! cell projection part
is_a: GO:0099568 ! cytoplasmic region
intersection_of: GO:0005737 ! cytoplasm
intersection_of: part_of GO:0042995 ! cell projection
relationship: part_of GO:0042995 ! cell projection

[Term]
id: GO:0032839
name: dendrite cytoplasm
namespace: cellular_component
def: "All of the contents of a dendrite, excluding the surrounding plasma membrane." [GOC:mah]
synonym: "dendritic cytoplasm" EXACT []
is_a: GO:0032838 ! cell projection cytoplasm
is_a: GO:0097458 ! neuron part
intersection_of: GO:0032838 ! cell projection cytoplasm
intersection_of: part_of GO:0030425 ! dendrite
relationship: part_of GO:0030425 ! dendrite

[Term]
id: GO:0032840
name: intramolecular proline-rich ligand binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a proline-rich region within the same polypeptide." [GOC:pf]
synonym: "intramolecular proline-rich region binding" EXACT []
is_a: GO:0043621 ! protein self-association
is_a: GO:0070064 ! proline-rich region binding

[Term]
id: GO:0032841
name: calcitonin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with calcitonin, a peptide hormone responsible for reducing serum calcium levels by inhibiting osteoclastic bone reabsorption and promoting renal calcium excretion. It is synthesized and released by the C cells of the thyroid." [GOC:ecd]
is_a: GO:0097644 ! calcitonin family binding

[Term]
id: GO:0032843
name: hydroperoxide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 RSH + ROOH = RSSR + ROH + H2O. This reaction is the thiol-dependent conversion of an organic hydroperoxide to the corresponding alcohol." [GOC:mlg, PMID:12540833]
is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor

[Term]
id: GO:0032844
name: regulation of homeostatic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a homeostatic process." [GOC:mah]
subset: gosubset_prok
is_a: GO:0050789 ! regulation of biological process
is_a: GO:0065008 ! regulation of biological quality
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042592 ! homeostatic process
relationship: regulates GO:0042592 ! homeostatic process

[Term]
id: GO:0032845
name: negative regulation of homeostatic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a homeostatic process." [GOC:mah]
synonym: "down regulation of homeostatic process" EXACT []
synonym: "down-regulation of homeostatic process" EXACT []
synonym: "downregulation of homeostatic process" EXACT []
synonym: "inhibition of homeostatic process" NARROW []
is_a: GO:0032844 ! regulation of homeostatic process
is_a: GO:0048519 ! negative regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042592 ! homeostatic process
relationship: negatively_regulates GO:0042592 ! homeostatic process

[Term]
id: GO:0032846
name: positive regulation of homeostatic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of a homeostatic process." [GOC:mah]
synonym: "activation of homeostatic process" NARROW []
synonym: "stimulation of homeostatic process" NARROW []
synonym: "up regulation of homeostatic process" EXACT []
synonym: "up-regulation of homeostatic process" EXACT []
synonym: "upregulation of homeostatic process" EXACT []
is_a: GO:0032844 ! regulation of homeostatic process
is_a: GO:0048518 ! positive regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042592 ! homeostatic process
relationship: positively_regulates GO:0042592 ! homeostatic process

[Term]
id: GO:0032847
name: regulation of cellular pH reduction
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a process that reduces the internal pH of a cell." [GOC:mah]
synonym: "regulation of cell pH reduction" EXACT []
synonym: "regulation of cellular acidification" EXACT []
synonym: "regulation of intracellular acidification" RELATED []
synonym: "regulation of intracellular pH reduction" EXACT []
synonym: "regulation of reduction of cellular pH" EXACT []
synonym: "regulation of reduction of pH in cell" EXACT []
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:0051453 ! regulation of intracellular pH
is_a: GO:2000021 ! regulation of ion homeostasis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051452 ! intracellular pH reduction
relationship: regulates GO:0051452 ! intracellular pH reduction

[Term]
id: GO:0032848
name: negative regulation of cellular pH reduction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a process that reduces the internal pH of a cell." [GOC:mah]
synonym: "down regulation of cellular pH reduction" EXACT []
synonym: "down-regulation of cellular pH reduction" EXACT []
synonym: "downregulation of cellular pH reduction" EXACT []
synonym: "inhibition of cellular pH reduction" NARROW []
synonym: "negative regulation of cell pH reduction" EXACT []
synonym: "negative regulation of cellular acidification" EXACT []
synonym: "negative regulation of intracellular acidification" RELATED []
synonym: "negative regulation of intracellular pH reduction" EXACT []
synonym: "negative regulation of reduction of cellular pH" EXACT []
synonym: "negative regulation of reduction of pH in cell" EXACT []
is_a: GO:0032845 ! negative regulation of homeostatic process
is_a: GO:0032847 ! regulation of cellular pH reduction
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051454 ! intracellular pH elevation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051452 ! intracellular pH reduction
relationship: negatively_regulates GO:0051452 ! intracellular pH reduction

[Term]
id: GO:0032849
name: positive regulation of cellular pH reduction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of a process that reduces the internal pH of a cell." [GOC:mah]
synonym: "activation of cellular pH reduction" NARROW []
synonym: "positive regulation of cell pH reduction" EXACT []
synonym: "positive regulation of cellular acidification" EXACT []
synonym: "positive regulation of intracellular acidification" RELATED []
synonym: "positive regulation of intracellular pH reduction" EXACT []
synonym: "positive regulation of reduction of cellular pH" EXACT []
synonym: "positive regulation of reduction of pH in cell" EXACT []
synonym: "stimulation of cellular pH reduction" NARROW []
synonym: "up regulation of cellular pH reduction" EXACT []
synonym: "up-regulation of cellular pH reduction" EXACT []
synonym: "upregulation of cellular pH reduction" EXACT []
is_a: GO:0032846 ! positive regulation of homeostatic process
is_a: GO:0032847 ! regulation of cellular pH reduction
is_a: GO:0048522 ! positive regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051452 ! intracellular pH reduction
relationship: positively_regulates GO:0051452 ! intracellular pH reduction

[Term]
id: GO:0032865
name: ERMES complex
namespace: cellular_component
def: "A protein complex that links the endoplasmic reticulum with mitochondria and may have a role in promoting exchange of calcium and phospholipids between the two organelles. The complex is also associated with actively replicating mitochondrial DNA nucleoids, and may further coordinate mitochondrial genome replication and membrane growth." [GOC:mcc, PMID:19556461]
synonym: "ER-mitochondria encounter structure" EXACT []
synonym: "Mdm10/Mdm12/Mmm1 complex" EXACT []
synonym: "mitochore" EXACT [GOC:mcc]
synonym: "MMM1 complex" EXACT [GOC:mcc]
is_a: GO:0044432 ! endoplasmic reticulum part
is_a: GO:0098799 ! outer mitochondrial membrane protein complex
relationship: part_of GO:0005741 ! mitochondrial outer membrane
relationship: part_of GO:0044233 ! ER-mitochondrion membrane contact site

[Term]
id: GO:0032866
name: D-xylose:NADP reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-xylitol + NADP+ = D-xylose + NADPH + H+." [PMID:12724380, PMID:15184173]
synonym: "D-xylose reductase activity" BROAD []
synonym: "xylose reductase activity" BROAD []
xref: EC:1.1.1.-
xref: MetaCyc:RXN-8773
xref: RHEA:27448
is_a: GO:0004032 ! alditol:NADP+ 1-oxidoreductase activity

[Term]
id: GO:0032867
name: L-arabinose:NADP reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arabitol + NADP+ = L-arabinose + NADPH + H+." [PMID:12724380, PMID:15184173]
synonym: "arabinose reductase activity" BROAD []
synonym: "arabinose:NADP reductase activity" BROAD []
xref: EC:1.1.1.-
xref: KEGG:R01759
xref: MetaCyc:RXN-8772
xref: SABIO-RK:1858
is_a: GO:0004032 ! alditol:NADP+ 1-oxidoreductase activity

[Term]
id: GO:0032868
name: response to insulin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732]
synonym: "response to insulin stimulus" EXACT [GOC:dos]
is_a: GO:0043434 ! response to peptide hormone

[Term]
id: GO:0032869
name: cellular response to insulin stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732]
is_a: GO:0032868 ! response to insulin
is_a: GO:0071375 ! cellular response to peptide hormone stimulus

[Term]
id: GO:0032870
name: cellular response to hormone stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:mah]
is_a: GO:0009725 ! response to hormone
is_a: GO:0071310 ! cellular response to organic substance
is_a: GO:0071495 ! cellular response to endogenous stimulus

[Term]
id: GO:0032871
name: regulation of karyogamy
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of karyogamy, the creation of a single nucleus from multiple nuclei as a result of membrane fusion." [GOC:mah]
is_a: GO:1903353 ! regulation of nucleus organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000741 ! karyogamy
relationship: regulates GO:0000741 ! karyogamy

[Term]
id: GO:0032872
name: regulation of stress-activated MAPK cascade
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade." [GOC:mah]
synonym: "regulation of p38 MAPK signaling" EXACT []
synonym: "regulation of p38 MAPK signalling" EXACT []
synonym: "regulation of stress-activated MAPK signaling pathway" EXACT []
synonym: "regulation of stress-activated MAPK signalling pathway" EXACT []
synonym: "regulation of stress-activated MAPKKK cascade" EXACT []
synonym: "regulation of stress-activated MAPKKK signaling pathway" EXACT []
synonym: "regulation of stress-activated MAPKKK signalling pathway" EXACT []
is_a: GO:0043408 ! regulation of MAPK cascade
is_a: GO:0070302 ! regulation of stress-activated protein kinase signaling cascade
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051403 ! stress-activated MAPK cascade
relationship: regulates GO:0051403 ! stress-activated MAPK cascade

[Term]
id: GO:0032873
name: negative regulation of stress-activated MAPK cascade
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade." [GOC:mah]
synonym: "down regulation of stress-activated MAPK cascade" EXACT []
synonym: "down-regulation of stress-activated MAPK cascade" EXACT []
synonym: "downregulation of stress-activated MAPK cascade" EXACT []
synonym: "inhibition of stress-activated MAPK cascade" NARROW []
synonym: "negative regulation of p38 MAPK signaling" EXACT []
synonym: "negative regulation of p38 MAPK signalling" EXACT []
synonym: "negative regulation of stress-activated MAPK signaling pathway" EXACT []
synonym: "negative regulation of stress-activated MAPK signalling pathway" EXACT []
synonym: "negative regulation of stress-activated MAPKKK cascade" EXACT []
synonym: "negative regulation of stress-activated MAPKKK signaling pathway" EXACT []
synonym: "negative regulation of stress-activated MAPKKK signalling pathway" EXACT []
is_a: GO:0032872 ! regulation of stress-activated MAPK cascade
is_a: GO:0043409 ! negative regulation of MAPK cascade
is_a: GO:0070303 ! negative regulation of stress-activated protein kinase signaling cascade
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051403 ! stress-activated MAPK cascade
relationship: negatively_regulates GO:0051403 ! stress-activated MAPK cascade

[Term]
id: GO:0032874
name: positive regulation of stress-activated MAPK cascade
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade." [GOC:mah]
synonym: "activation of stress-activated MAPK cascade" NARROW []
synonym: "positive regulation of p38 MAPK signaling" EXACT []
synonym: "positive regulation of p38 MAPK signalling" EXACT []
synonym: "positive regulation of stress-activated MAPK signaling pathway" EXACT []
synonym: "positive regulation of stress-activated MAPK signalling pathway" EXACT []
synonym: "positive regulation of stress-activated MAPKKK cascade" EXACT []
synonym: "positive regulation of stress-activated MAPKKK signaling pathway" EXACT []
synonym: "positive regulation of stress-activated MAPKKK signalling pathway" EXACT []
synonym: "stimulation of stress-activated MAPK cascade" NARROW []
synonym: "up regulation of stress-activated MAPK cascade" EXACT []
synonym: "up-regulation of stress-activated MAPK cascade" EXACT []
synonym: "upregulation of stress-activated MAPK cascade" EXACT []
is_a: GO:0032872 ! regulation of stress-activated MAPK cascade
is_a: GO:0043410 ! positive regulation of MAPK cascade
is_a: GO:0070304 ! positive regulation of stress-activated protein kinase signaling cascade
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051403 ! stress-activated MAPK cascade
relationship: positively_regulates GO:0051403 ! stress-activated MAPK cascade

[Term]
id: GO:0032875
name: regulation of DNA endoreduplication
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA endoreduplication." [GOC:mah]
synonym: "regulation of DNA endoreplication" EXACT []
synonym: "regulation of DNA re-duplication" EXACT []
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0090329 ! regulation of DNA-dependent DNA replication
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042023 ! DNA endoreduplication
relationship: regulates GO:0042023 ! DNA endoreduplication

[Term]
id: GO:0032876
name: negative regulation of DNA endoreduplication
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA endoreduplication." [GOC:mah]
synonym: "down regulation of DNA endoreduplication" EXACT []
synonym: "down-regulation of DNA endoreduplication" EXACT []
synonym: "downregulation of DNA endoreduplication" EXACT []
synonym: "inhibition of DNA endoreduplication" NARROW []
synonym: "negative regulation of DNA endoreplication" EXACT []
synonym: "negative regulation of DNA re-duplication" EXACT []
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0032875 ! regulation of DNA endoreduplication
is_a: GO:2000104 ! negative regulation of DNA-dependent DNA replication
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042023 ! DNA endoreduplication
relationship: negatively_regulates GO:0042023 ! DNA endoreduplication

[Term]
id: GO:0032877
name: positive regulation of DNA endoreduplication
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA endoreduplication." [GOC:mah]
synonym: "activation of DNA endoreduplication" NARROW []
synonym: "positive regulation of DNA endoreplication" EXACT []
synonym: "positive regulation of DNA re-duplication" EXACT []
synonym: "stimulation of DNA endoreduplication" NARROW []
synonym: "up regulation of DNA endoreduplication" EXACT []
synonym: "up-regulation of DNA endoreduplication" EXACT []
synonym: "upregulation of DNA endoreduplication" EXACT []
is_a: GO:0032875 ! regulation of DNA endoreduplication
is_a: GO:0090068 ! positive regulation of cell cycle process
is_a: GO:2000105 ! positive regulation of DNA-dependent DNA replication
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042023 ! DNA endoreduplication
relationship: positively_regulates GO:0042023 ! DNA endoreduplication

[Term]
id: GO:0032878
name: regulation of establishment or maintenance of cell polarity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah]
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007163 ! establishment or maintenance of cell polarity
relationship: regulates GO:0007163 ! establishment or maintenance of cell polarity

[Term]
id: GO:0032879
name: regulation of localization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of localisation" EXACT [GOC:mah]
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051179 ! localization
relationship: regulates GO:0051179 ! localization

[Term]
id: GO:0032880
name: regulation of protein localization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb]
subset: goslim_chembl
subset: gosubset_prok
synonym: "regulation of protein localisation" EXACT [GOC:mah]
is_a: GO:0032879 ! regulation of localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008104 ! protein localization
relationship: regulates GO:0008104 ! protein localization

[Term]
id: GO:0032881
name: regulation of polysaccharide metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving polysaccharides." [GOC:mah]
subset: gosubset_prok
is_a: GO:0006109 ! regulation of carbohydrate metabolic process
is_a: GO:0060255 ! regulation of macromolecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0005976 ! polysaccharide metabolic process
relationship: regulates GO:0005976 ! polysaccharide metabolic process

[Term]
id: GO:0032882
name: regulation of chitin metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving chitin." [GOC:mah]
synonym: "regulation of chitin metabolism" EXACT []
is_a: GO:0032881 ! regulation of polysaccharide metabolic process
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006030 ! chitin metabolic process
relationship: regulates GO:0006030 ! chitin metabolic process

[Term]
id: GO:0032883
name: regulation of chitin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chitin." [GOC:mah]
synonym: "regulation of chitin anabolism" EXACT []
synonym: "regulation of chitin biosynthesis" RELATED []
synonym: "regulation of chitin formation" EXACT []
synonym: "regulation of chitin synthesis" EXACT []
is_a: GO:0032882 ! regulation of chitin metabolic process
is_a: GO:0032885 ! regulation of polysaccharide biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006031 ! chitin biosynthetic process
relationship: regulates GO:0006031 ! chitin biosynthetic process

[Term]
id: GO:0032884
name: regulation of cell wall chitin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cell wall chitin." [GOC:mah]
synonym: "regulation of cell wall chitin anabolism" EXACT []
synonym: "regulation of cell wall chitin biosynthesis" EXACT []
synonym: "regulation of cell wall chitin formation" EXACT []
synonym: "regulation of cell wall chitin synthesis" EXACT []
is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process
is_a: GO:0032883 ! regulation of chitin biosynthetic process
is_a: GO:0034222 ! regulation of cell wall chitin metabolic process
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006038 ! cell wall chitin biosynthetic process
relationship: regulates GO:0006038 ! cell wall chitin biosynthetic process

[Term]
id: GO:0032885
name: regulation of polysaccharide biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides." [GOC:mah]
subset: gosubset_prok
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
is_a: GO:0032881 ! regulation of polysaccharide metabolic process
is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000271 ! polysaccharide biosynthetic process
relationship: regulates GO:0000271 ! polysaccharide biosynthetic process

[Term]
id: GO:0032886
name: regulation of microtubule-based process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton." [GOC:mah]
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007017 ! microtubule-based process
relationship: regulates GO:0007017 ! microtubule-based process

[Term]
id: GO:0032887
name: regulation of spindle elongation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the spindle." [GOC:mah]
is_a: GO:0051983 ! regulation of chromosome segregation
is_a: GO:0090224 ! regulation of spindle organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051231 ! spindle elongation
relationship: regulates GO:0051231 ! spindle elongation

[Term]
id: GO:0032888
name: regulation of mitotic spindle elongation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle." [GOC:mah]
is_a: GO:0032887 ! regulation of spindle elongation
is_a: GO:0033047 ! regulation of mitotic sister chromatid segregation
is_a: GO:0060236 ! regulation of mitotic spindle organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000022 ! mitotic spindle elongation
relationship: regulates GO:0000022 ! mitotic spindle elongation

[Term]
id: GO:0032889
name: regulation of vacuole fusion, non-autophagic
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the fusion of two vacuole membranes to form a single vacuole." [GOC:mah]
is_a: GO:0044088 ! regulation of vacuole organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042144 ! vacuole fusion, non-autophagic
relationship: regulates GO:0042144 ! vacuole fusion, non-autophagic

[Term]
id: GO:0032890
name: regulation of organic acid transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0015849 ! organic acid transport
relationship: regulates GO:0015849 ! organic acid transport

[Term]
id: GO:0032891
name: negative regulation of organic acid transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "down regulation of organic acid transport" EXACT []
synonym: "down-regulation of organic acid transport" EXACT []
synonym: "downregulation of organic acid transport" EXACT []
synonym: "inhibition of organic acid transport" NARROW []
is_a: GO:0032890 ! regulation of organic acid transport
is_a: GO:0051051 ! negative regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0015849 ! organic acid transport
relationship: negatively_regulates GO:0015849 ! organic acid transport

[Term]
id: GO:0032892
name: positive regulation of organic acid transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "activation of organic acid transport" NARROW []
synonym: "stimulation of organic acid transport" NARROW []
synonym: "up regulation of organic acid transport" EXACT []
synonym: "up-regulation of organic acid transport" EXACT []
synonym: "upregulation of organic acid transport" EXACT []
is_a: GO:0032890 ! regulation of organic acid transport
is_a: GO:0051050 ! positive regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0015849 ! organic acid transport
relationship: positively_regulates GO:0015849 ! organic acid transport

[Term]
id: GO:0032893
name: regulation of gluconate transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of gluconate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
is_a: GO:0032890 ! regulation of organic acid transport
is_a: GO:0044070 ! regulation of anion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0015725 ! gluconate transport
relationship: regulates GO:0015725 ! gluconate transport

[Term]
id: GO:0032894
name: negative regulation of gluconate transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of gluconate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "down regulation of gluconate transport" EXACT []
synonym: "down-regulation of gluconate transport" EXACT []
synonym: "downregulation of gluconate transport" EXACT []
synonym: "inhibition of gluconate transport" NARROW []
is_a: GO:0032891 ! negative regulation of organic acid transport
is_a: GO:0032893 ! regulation of gluconate transport
is_a: GO:1903792 ! negative regulation of anion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0015725 ! gluconate transport
relationship: negatively_regulates GO:0015725 ! gluconate transport

[Term]
id: GO:0032895
name: positive regulation of gluconate transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of gluconate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "activation of gluconate transport" NARROW []
synonym: "induction of gluconate transport" NARROW []
synonym: "stimulation of gluconate transport" NARROW []
synonym: "up regulation of gluconate transport" EXACT []
synonym: "up-regulation of gluconate transport" EXACT []
synonym: "upregulation of gluconate transport" EXACT []
is_a: GO:0032892 ! positive regulation of organic acid transport
is_a: GO:0032893 ! regulation of gluconate transport
is_a: GO:1903793 ! positive regulation of anion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0015725 ! gluconate transport
relationship: positively_regulates GO:0015725 ! gluconate transport

[Term]
id: GO:0032896
name: palmitoyl-CoA 9-desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: palmitoyl-CoA + AH2 + O2 = palmitoleic acid (16:1delta9) + A + 2 H2O." [GOC:kmv]
synonym: "palmitoyl-CoA delta9-desaturase acitivity" EXACT []
is_a: GO:0016215 ! acyl-CoA desaturase activity

[Term]
id: GO:0032897
name: negative regulation of viral transcription
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of viral transcription." [GOC:mah]
synonym: "down regulation of viral transcription" EXACT []
synonym: "down-regulation of viral transcription" EXACT []
synonym: "downregulation of viral transcription" EXACT []
synonym: "inhibition of viral transcription" NARROW []
is_a: GO:0010629 ! negative regulation of gene expression
is_a: GO:0046782 ! regulation of viral transcription
is_a: GO:1902679 ! negative regulation of RNA biosynthetic process
is_a: GO:1903901 ! negative regulation of viral life cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019083 ! viral transcription
relationship: negatively_regulates GO:0019083 ! viral transcription

[Term]
id: GO:0032898
name: neurotrophin production
namespace: biological_process
def: "The appearance of a neurotrophin due to biosynthesis or secretion by cells in a neuron's target field, resulting in an increase in its intracellular or extracellular levels. A neurotrophin is any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth." [GOC:ecd, GOC:mah, GOC:mtg_MIT_16mar07]
is_a: GO:0044707 ! single-multicellular organism process

[Term]
id: GO:0032899
name: regulation of neurotrophin production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of a neurotrophin." [GOC:mah]
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032898 ! neurotrophin production
relationship: regulates GO:0032898 ! neurotrophin production

[Term]
id: GO:0032900
name: negative regulation of neurotrophin production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of a neurotrophin." [GOC:mah]
synonym: "down regulation of neurotrophin production" EXACT []
synonym: "down-regulation of neurotrophin production" EXACT []
synonym: "downregulation of neurotrophin production" EXACT []
synonym: "inhibition of neurotrophin production" NARROW []
is_a: GO:0032899 ! regulation of neurotrophin production
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032898 ! neurotrophin production
relationship: negatively_regulates GO:0032898 ! neurotrophin production

[Term]
id: GO:0032901
name: positive regulation of neurotrophin production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of production of a neurotrophin." [GOC:mah]
synonym: "activation of neurotrophin production" NARROW []
synonym: "stimulation of neurotrophin production" NARROW []
synonym: "up regulation of neurotrophin production" EXACT []
synonym: "up-regulation of neurotrophin production" EXACT []
synonym: "upregulation of neurotrophin production" EXACT []
is_a: GO:0032899 ! regulation of neurotrophin production
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032898 ! neurotrophin production
relationship: positively_regulates GO:0032898 ! neurotrophin production

[Term]
id: GO:0032902
name: nerve growth factor production
namespace: biological_process
def: "The appearance of nerve growth factor (NGF) due to biosynthesis or secretion by cells in a neuron's target field, resulting in an increase in its intracellular or extracellular levels." [GOC:ecd, GOC:mah]
synonym: "beta-nerve growth factor production" EXACT [PR:000011194]
synonym: "NGF production" EXACT []
is_a: GO:0032898 ! neurotrophin production

[Term]
id: GO:0032903
name: regulation of nerve growth factor production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of nerve growth factor (NGF)." [GOC:mah]
synonym: "regulation of beta-nerve growth factor production" EXACT [PR:000011194]
synonym: "regulation of NGF production" EXACT []
is_a: GO:0032899 ! regulation of neurotrophin production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032902 ! nerve growth factor production
relationship: regulates GO:0032902 ! nerve growth factor production

[Term]
id: GO:0032904
name: negative regulation of nerve growth factor production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of nerve growth factor (NGF)." [GOC:mah]
synonym: "down regulation of nerve growth factor production" EXACT []
synonym: "down-regulation of nerve growth factor production" EXACT []
synonym: "downregulation of nerve growth factor production" EXACT []
synonym: "inhibition of nerve growth factor production" NARROW []
synonym: "negative regulation of NGF production" EXACT []
is_a: GO:0032900 ! negative regulation of neurotrophin production
is_a: GO:0032903 ! regulation of nerve growth factor production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032902 ! nerve growth factor production
relationship: negatively_regulates GO:0032902 ! nerve growth factor production

[Term]
id: GO:0032905
name: transforming growth factor beta1 production
namespace: biological_process
def: "The appearance of transforming growth factor-beta1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "TGF-B1 production" EXACT []
synonym: "TGFB1 production" EXACT []
synonym: "transforming growth factor-beta1 production" EXACT [GOC:bf]
is_a: GO:0071604 ! transforming growth factor beta production

[Term]
id: GO:0032906
name: transforming growth factor beta2 production
namespace: biological_process
def: "The appearance of transforming growth factor-beta2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "TGF-B2 production" EXACT []
synonym: "TGFB2 production" EXACT []
synonym: "transforming growth factor-beta2 production" EXACT [GOC:bf]
is_a: GO:0071604 ! transforming growth factor beta production

[Term]
id: GO:0032907
name: transforming growth factor beta3 production
namespace: biological_process
def: "The appearance of transforming growth factor-beta3 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "TGF-B3 production" EXACT []
synonym: "TGFB3 production" EXACT []
synonym: "transforming growth factor-beta3 production" EXACT [GOC:bf]
is_a: GO:0071604 ! transforming growth factor beta production

[Term]
id: GO:0032908
name: regulation of transforming growth factor beta1 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta1." [GOC:mah]
synonym: "regulation of TGF-B1 production" EXACT []
synonym: "regulation of TGFB1 production" EXACT []
synonym: "regulation of transforming growth factor-beta1 production" EXACT [GOC:bf]
is_a: GO:0071634 ! regulation of transforming growth factor beta production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032905 ! transforming growth factor beta1 production
relationship: regulates GO:0032905 ! transforming growth factor beta1 production

[Term]
id: GO:0032909
name: regulation of transforming growth factor beta2 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta2." [GOC:mah]
synonym: "regulation of TGF-B2 production" EXACT []
synonym: "regulation of TGFB2 production" EXACT []
synonym: "regulation of transforming growth factor-beta2 production" EXACT [GOC:bf]
is_a: GO:0071634 ! regulation of transforming growth factor beta production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032906 ! transforming growth factor beta2 production
relationship: regulates GO:0032906 ! transforming growth factor beta2 production

[Term]
id: GO:0032910
name: regulation of transforming growth factor beta3 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta3." [GOC:mah]
synonym: "regulation of TGF-B3 production" EXACT []
synonym: "regulation of TGFB3 production" EXACT []
synonym: "regulation of transforming growth factor-beta3 production" EXACT [GOC:bf]
is_a: GO:0071634 ! regulation of transforming growth factor beta production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032907 ! transforming growth factor beta3 production
relationship: regulates GO:0032907 ! transforming growth factor beta3 production

[Term]
id: GO:0032911
name: negative regulation of transforming growth factor beta1 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta1." [GOC:mah]
synonym: "down regulation of transforming growth factor-beta1 production" EXACT []
synonym: "down-regulation of transforming growth factor-beta1 production" EXACT []
synonym: "downregulation of transforming growth factor-beta1 production" EXACT []
synonym: "inhibition of transforming growth factor-beta1 production" NARROW []
synonym: "negative regulation of TGF-B1 production" EXACT []
synonym: "negative regulation of TGFB1 production" EXACT []
synonym: "negative regulation of transforming growth factor-beta1 production" EXACT [GOC:bf]
is_a: GO:0032908 ! regulation of transforming growth factor beta1 production
is_a: GO:0071635 ! negative regulation of transforming growth factor beta production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032905 ! transforming growth factor beta1 production
relationship: negatively_regulates GO:0032905 ! transforming growth factor beta1 production

[Term]
id: GO:0032912
name: negative regulation of transforming growth factor beta2 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta2." [GOC:mah]
synonym: "down regulation of transforming growth factor-beta2 production" EXACT []
synonym: "down-regulation of transforming growth factor-beta2 production" EXACT []
synonym: "downregulation of transforming growth factor-beta2 production" EXACT []
synonym: "inhibition of transforming growth factor-beta2 production" NARROW []
synonym: "negative regulation of TGF-B2 production" EXACT []
synonym: "negative regulation of TGFB2 production" EXACT []
synonym: "negative regulation of transforming growth factor-beta2 production" EXACT [GOC:bf]
is_a: GO:0032909 ! regulation of transforming growth factor beta2 production
is_a: GO:0071635 ! negative regulation of transforming growth factor beta production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032906 ! transforming growth factor beta2 production
relationship: negatively_regulates GO:0032906 ! transforming growth factor beta2 production

[Term]
id: GO:0032913
name: negative regulation of transforming growth factor beta3 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta3." [GOC:mah]
synonym: "down regulation of transforming growth factor-beta3 production" EXACT []
synonym: "down-regulation of transforming growth factor-beta3 production" EXACT []
synonym: "downregulation of transforming growth factor-beta3 production" EXACT []
synonym: "inhibition of transforming growth factor-beta3 production" NARROW []
synonym: "negative regulation of TGF-B3 production" EXACT []
synonym: "negative regulation of TGFB3 production" EXACT []
synonym: "negative regulation of transforming growth factor-beta3 production" EXACT [GOC:bf]
is_a: GO:0032910 ! regulation of transforming growth factor beta3 production
is_a: GO:0071635 ! negative regulation of transforming growth factor beta production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032907 ! transforming growth factor beta3 production
relationship: negatively_regulates GO:0032907 ! transforming growth factor beta3 production

[Term]
id: GO:0032914
name: positive regulation of transforming growth factor beta1 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta1." [GOC:mah]
synonym: "activation of transforming growth factor-beta1 production" NARROW [GOC:bf]
synonym: "positive regulation of TGF-B1 production" EXACT []
synonym: "positive regulation of TGFB1 production" EXACT []
synonym: "stimulation of transforming growth factor-beta1 production" NARROW []
synonym: "up regulation of transforming growth factor-beta1 production" EXACT []
synonym: "up-regulation of transforming growth factor-beta1 production" EXACT []
synonym: "upregulation of transforming growth factor-beta1 production" EXACT []
is_a: GO:0032908 ! regulation of transforming growth factor beta1 production
is_a: GO:0071636 ! positive regulation of transforming growth factor beta production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032905 ! transforming growth factor beta1 production
relationship: positively_regulates GO:0032905 ! transforming growth factor beta1 production

[Term]
id: GO:0032915
name: positive regulation of transforming growth factor beta2 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta2." [GOC:mah]
synonym: "activation of transforming growth factor-beta2 production" NARROW []
synonym: "positive regulation of TGF-B2 production" EXACT []
synonym: "positive regulation of TGFB2 production" EXACT []
synonym: "positive regulation of transforming growth factor-beta2 production" EXACT [GOC:bf]
synonym: "stimulation of transforming growth factor-beta2 production" NARROW []
synonym: "up regulation of transforming growth factor-beta2 production" EXACT []
synonym: "up-regulation of transforming growth factor-beta2 production" EXACT []
synonym: "upregulation of transforming growth factor-beta2 production" EXACT []
is_a: GO:0032909 ! regulation of transforming growth factor beta2 production
is_a: GO:0071636 ! positive regulation of transforming growth factor beta production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032906 ! transforming growth factor beta2 production
relationship: positively_regulates GO:0032906 ! transforming growth factor beta2 production

[Term]
id: GO:0032916
name: positive regulation of transforming growth factor beta3 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta3." [GOC:mah]
synonym: "activation of transforming growth factor-beta3 production" NARROW []
synonym: "positive regulation of TGF-B3 production" EXACT []
synonym: "positive regulation of TGFB3 production" EXACT []
synonym: "positive regulation of transforming growth factor-beta3 production" EXACT [GOC:bf]
synonym: "stimulation of transforming growth factor-beta3 production" NARROW []
synonym: "up regulation of transforming growth factor-beta3 production" EXACT []
synonym: "up-regulation of transforming growth factor-beta3 production" EXACT []
synonym: "upregulation of transforming growth factor-beta3 production" EXACT []
is_a: GO:0032910 ! regulation of transforming growth factor beta3 production
is_a: GO:0071636 ! positive regulation of transforming growth factor beta production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032907 ! transforming growth factor beta3 production
relationship: positively_regulates GO:0032907 ! transforming growth factor beta3 production

[Term]
id: GO:0032917
name: polyamine acetylation
namespace: biological_process
def: "The modification of polyamines by addition of acetyl groups." [GOC:mlg]
is_a: GO:0006595 ! polyamine metabolic process

[Term]
id: GO:0032918
name: spermidine acetylation
namespace: biological_process
def: "The modification of spermidine by addition of acetyl groups." [GOC:mlg]
is_a: GO:0008216 ! spermidine metabolic process
is_a: GO:0032917 ! polyamine acetylation

[Term]
id: GO:0032919
name: spermine acetylation
namespace: biological_process
def: "The modification of spermine by addition of acetyl groups." [GOC:mlg]
is_a: GO:0008215 ! spermine metabolic process
is_a: GO:0032917 ! polyamine acetylation

[Term]
id: GO:0032920
name: putrescine acetylation
namespace: biological_process
def: "The modification of putrescine by addition of acetyl groups." [GOC:mlg]
is_a: GO:0009445 ! putrescine metabolic process
is_a: GO:0032917 ! polyamine acetylation

[Term]
id: GO:0032921
name: sarcosine oxidase complex
namespace: cellular_component
def: "A complex consisting of 4 protein subunits as a heterotetramer, that possesses sarcosine oxidase activity." [GOC:mah, GOC:mlg]
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:0032922
name: circadian regulation of gene expression
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours." [GOC:mah]
synonym: "circadian regulation of protein expression" RELATED []
synonym: "diurnal variation of gene expression" RELATED []
synonym: "diurnal variation of protein expression" RELATED []
is_a: GO:0007623 ! circadian rhythm
is_a: GO:0010468 ! regulation of gene expression
is_a: GO:0044707 ! single-multicellular organism process

[Term]
id: GO:0032923
name: organic phosphonate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phosphonates, any organic compound containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Synthesis of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included." [GOC:js]
synonym: "organophosphonate biosynthetic process" RELATED []
is_a: GO:0019634 ! organic phosphonate metabolic process
is_a: GO:0044249 ! cellular biosynthetic process
is_a: GO:0090407 ! organophosphate biosynthetic process

[Term]
id: GO:0032924
name: activin receptor signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of an extracellular ligand to an activin receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:rl, GOC:signaling]
synonym: "activin receptor signalling pathway" EXACT []
is_a: GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway

[Term]
id: GO:0032925
name: regulation of activin receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the activity of any activin receptor signaling pathway." [GOC:BHF, GOC:rl]
synonym: "regulation of activin receptor signalling pathway" EXACT []
synonym: "regulation of activin signaling pathway" RELATED []
synonym: "regulation of activin signalling pathway" RELATED []
is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032924 ! activin receptor signaling pathway
relationship: regulates GO:0032924 ! activin receptor signaling pathway

[Term]
id: GO:0032926
name: negative regulation of activin receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of any activin receptor signaling pathway." [GOC:BHF, GOC:rl]
synonym: "down regulation of activin receptor signaling pathway" EXACT []
synonym: "down-regulation of activin receptor signaling pathway" EXACT []
synonym: "downregulation of activin receptor signaling pathway" EXACT []
synonym: "inhibition of activin receptor signaling pathway" NARROW []
synonym: "negative regulation of activin receptor signalling pathway" EXACT []
synonym: "negative regulation of activin signaling pathway" RELATED []
synonym: "negative regulation of activin signalling pathway" RELATED []
is_a: GO:0032925 ! regulation of activin receptor signaling pathway
is_a: GO:0090101 ! negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032924 ! activin receptor signaling pathway
relationship: negatively_regulates GO:0032924 ! activin receptor signaling pathway

[Term]
id: GO:0032927
name: positive regulation of activin receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the activity of any activin receptor signaling pathway." [GOC:BHF, GOC:rl]
synonym: "activation of activin receptor signaling pathway" NARROW []
synonym: "positive regulation of activin receptor signalling pathway" EXACT []
synonym: "positive regulation of activin signaling pathway" RELATED []
synonym: "positive regulation of activin signalling pathway" RELATED []
synonym: "stimulation of activin receptor signaling pathway" NARROW []
synonym: "up regulation of activin receptor signaling pathway" EXACT []
synonym: "up-regulation of activin receptor signaling pathway" EXACT []
synonym: "upregulation of activin receptor signaling pathway" EXACT []
is_a: GO:0032925 ! regulation of activin receptor signaling pathway
is_a: GO:0090100 ! positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032924 ! activin receptor signaling pathway
relationship: positively_regulates GO:0032924 ! activin receptor signaling pathway

[Term]
id: GO:0032928
name: regulation of superoxide anion generation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of enzymatic generation of superoxide by a cell." [GOC:mah]
synonym: "regulation of superoxide release" EXACT [GOC:dph, GOC:tb]
is_a: GO:0090322 ! regulation of superoxide metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042554 ! superoxide anion generation
relationship: regulates GO:0042554 ! superoxide anion generation

[Term]
id: GO:0032929
name: negative regulation of superoxide anion generation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of enzymatic generation of superoxide by a cell." [GOC:mah]
synonym: "down regulation of superoxide release" EXACT []
synonym: "down-regulation of superoxide release" EXACT []
synonym: "downregulation of superoxide release" EXACT []
synonym: "inhibition of superoxide release" NARROW []
synonym: "negative regulation of superoxide release" EXACT [GOC:dph, GOC:tb]
is_a: GO:0032928 ! regulation of superoxide anion generation
is_a: GO:2000378 ! negative regulation of reactive oxygen species metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042554 ! superoxide anion generation
relationship: negatively_regulates GO:0042554 ! superoxide anion generation

[Term]
id: GO:0032930
name: positive regulation of superoxide anion generation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of enzymatic generation of superoxide by a cell." [GOC:mah]
synonym: "activation of superoxide release" NARROW []
synonym: "positive regulation of superoxide release" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of superoxide release" NARROW []
synonym: "up regulation of superoxide release" EXACT []
synonym: "up-regulation of superoxide release" EXACT []
synonym: "upregulation of superoxide release" EXACT []
is_a: GO:0032928 ! regulation of superoxide anion generation
is_a: GO:2000379 ! positive regulation of reactive oxygen species metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042554 ! superoxide anion generation
relationship: positively_regulates GO:0042554 ! superoxide anion generation

[Term]
id: GO:0032931
name: histone acetyltransferase activity (H3-K56 specific)
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 56) = CoA + histone H3 N6-acetyl-L-lysine (position 56)." [EC:2.3.1.48]
synonym: "histone lysine N-acetyltransferase activity (H3-K56 specific)" EXACT []
is_a: GO:0010484 ! H3 histone acetyltransferase activity
relationship: part_of GO:0097043 ! histone H3-K56 acetylation

[Term]
id: GO:0032932
name: negative regulation of astral microtubule depolymerization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the depolymerization of astral microtubules." [GOC:mah]
synonym: "astral microtubule stabilization" EXACT []
is_a: GO:0007026 ! negative regulation of microtubule depolymerization
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0031117 ! positive regulation of microtubule depolymerization
is_a: GO:0090224 ! regulation of spindle organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060172 ! astral microtubule depolymerization
relationship: negatively_regulates GO:0060172 ! astral microtubule depolymerization

[Term]
id: GO:0032933
name: SREBP signaling pathway
namespace: biological_process
alt_id: GO:0006994
alt_id: GO:0030967
alt_id: GO:0035104
def: "A series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of decreased levels of one or more sterols (and in some yeast, changes in oxygen levels) and which proceeds through activation of a sterol response element binding transcription factor (SREBP) to result in up-regulation of target gene transcription." [GOC:bf, GOC:mah, GOC:signaling, GOC:vw, PMID:12923525, PMID:22017871]
synonym: "activation of sterol regulatory element binding protein target gene transcription" NARROW []
synonym: "endoplasmic reticulum to nucleus sterol response pathway" EXACT []
synonym: "endoplasmic reticulum-nuclear sterol response pathway" EXACT []
synonym: "ER to nucleus sterol response pathway" EXACT []
synonym: "ER-nuclear sterol response pathway" EXACT []
synonym: "positive regulation of sterol regulatory element binding protein target gene transcription" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of sterol regulatory element binding protein target gene transcription involved in sterol depletion response" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of transcription via sterol regulatory element binding" NARROW [GOC:vw]
synonym: "positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway" NARROW [GOC:vw]
synonym: "SREBP signalling" EXACT [GOC:bf]
synonym: "SREBP target gene transcriptional activation" EXACT []
synonym: "SREBP-mediated signaling pathway" RELATED []
synonym: "SREBP-mediated signalling pathway" EXACT []
synonym: "sterol depletion response, SREBP target gene transcriptional activation" EXACT [GOC:dph, GOC:mtg_lung]
synonym: "sterol regulatory element binding protein target gene transcriptional activation" BROAD []
synonym: "sterol response element binding protein signaling pathway" EXACT [GOC:bf]
synonym: "stimulation of sterol regulatory element binding protein target gene transcription" NARROW []
synonym: "up regulation of sterol regulatory element binding protein target gene transcription" EXACT []
synonym: "up-regulation of sterol regulatory element binding protein target gene transcription" EXACT []
synonym: "upregulation of sterol regulatory element binding protein target gene transcription" EXACT []
is_a: GO:0006984 ! ER-nucleus signaling pathway
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
is_a: GO:0071501 ! cellular response to sterol depletion

[Term]
id: GO:0032934
name: sterol binding
namespace: molecular_function
alt_id: GO:0005498
def: "Interacting selectively and non-covalently with a sterol, any steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol." [CHEBI:15889, GOC:mah]
subset: gosubset_prok
synonym: "sterol carrier activity" RELATED [GOC:mah]
is_a: GO:0005496 ! steroid binding
is_a: GO:0043178 ! alcohol binding

[Term]
id: GO:0032935
name: sterol sensor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with and responding, e.g. by conformational change, to changes in the cellular level of a sterol." [GOC:mah]
synonym: "sterol-sensing domain" NARROW []
is_a: GO:0032934 ! sterol binding

[Term]
id: GO:0032936
name: SREBP-SCAP complex
namespace: cellular_component
def: "A protein complex formed by the association of sterol regulatory element binding protein (SREBP) and SREBP-cleavage-activating protein (SCAP) in the ER membrane; in the absence of sterols, the SREBP-SCAP complex is packaged into COPII vesicles and travels to the Golgi apparatus to be processed." [PMID:12923525]
synonym: "Sre1-Scp1 complex" EXACT []
is_a: GO:0098796 ! membrane protein complex

[Term]
id: GO:0032937
name: SREBP-SCAP-Insig complex
namespace: cellular_component
def: "A protein complex formed by the association of sterol regulatory element binding protein (SREBP), SREBP-cleavage-activating protein (SCAP), and an Insig protein (Insig-1 or Insig-2) in the ER membrane." [PMID:12923525]
is_a: GO:0044432 ! endoplasmic reticulum part
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0030176 ! integral component of endoplasmic reticulum membrane

[Term]
id: GO:0032938
name: negative regulation of translation in response to oxidative stress
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah]
is_a: GO:0032055 ! negative regulation of translation in response to stress
is_a: GO:0043556 ! regulation of translation in response to oxidative stress

[Term]
id: GO:0032939
name: positive regulation of translation in response to oxidative stress
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah]
synonym: "activation of translation in response to oxidative stress" NARROW []
synonym: "stimulation of translation in response to oxidative stress" NARROW []
synonym: "up regulation of translation in response to oxidative stress" EXACT []
synonym: "up-regulation of translation in response to oxidative stress" EXACT []
synonym: "upregulation of translation in response to oxidative stress" EXACT []
is_a: GO:0032056 ! positive regulation of translation in response to stress
is_a: GO:0043556 ! regulation of translation in response to oxidative stress

[Term]
id: GO:0032940
name: secretion by cell
namespace: biological_process
def: "The controlled release of a substance by a cell." [GOC:mah]
synonym: "cellular secretion" EXACT []
xref: Wikipedia:Secretion
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0046903 ! secretion

[Term]
id: GO:0032941
name: secretion by tissue
namespace: biological_process
def: "The controlled release of a substance by a tissue." [GOC:mah]
synonym: "expulsion of gland contents" RELATED [GOC:mah]
synonym: "tissue secretion" EXACT []
is_a: GO:0044707 ! single-multicellular organism process
is_a: GO:0046903 ! secretion

[Term]
id: GO:0032942
name: inositol tetrakisphosphate 2-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol tetrakisphosphate + ATP = 1D-myo-inositol pentakisphosphate (containing 2-phosphate) + ADP." [GOC:hf]
synonym: "1D-myo-inositol-tetrakisphosphate 2-kinase activity" EXACT []
synonym: "inositol 1,3,4,6-tetrakisphosphate 2-kinase activity" EXACT []
synonym: "inositol-tetrakisphosphate 2-kinase activity" EXACT []
xref: EC:2.7.1.-
is_a: GO:0051765 ! inositol tetrakisphosphate kinase activity

[Term]
id: GO:0032943
name: mononuclear cell proliferation
namespace: biological_process
def: "The expansion of a mononuclear cell population by cell division. A mononuclear cell is a leukocyte with a single non-segmented nucleus in the mature form." [GOC:add]
synonym: "PBMC proliferation" NARROW []
synonym: "peripheral blood mononuclear cell proliferation" NARROW []
is_a: GO:0070661 ! leukocyte proliferation

[Term]
id: GO:0032944
name: regulation of mononuclear cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mononuclear cell proliferation." [GOC:add]
synonym: "regulation of PBMC proliferation" NARROW []
synonym: "regulation of peripheral blood mononuclear cell proliferation" NARROW []
is_a: GO:0070663 ! regulation of leukocyte proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032943 ! mononuclear cell proliferation
relationship: regulates GO:0032943 ! mononuclear cell proliferation

[Term]
id: GO:0032945
name: negative regulation of mononuclear cell proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mononuclear cell proliferation." [GOC:add]
synonym: "negative regulation of PBMC proliferation" NARROW []
synonym: "negative regulation of peripheral blood mononuclear cell proliferation" NARROW []
is_a: GO:0032944 ! regulation of mononuclear cell proliferation
is_a: GO:0070664 ! negative regulation of leukocyte proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032943 ! mononuclear cell proliferation
relationship: negatively_regulates GO:0032943 ! mononuclear cell proliferation

[Term]
id: GO:0032946
name: positive regulation of mononuclear cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mononuclear cell proliferation." [GOC:add]
synonym: "activation of mononuclear cell proliferation" NARROW []
synonym: "positive regulation of PBMC proliferation" NARROW []
synonym: "positive regulation of peripheral blood mononuclear cell proliferation" NARROW []
synonym: "stimulation of mononuclear cell proliferation" NARROW []
synonym: "up regulation of mononuclear cell proliferation" EXACT []
synonym: "up-regulation of mononuclear cell proliferation" EXACT []
synonym: "upregulation of mononuclear cell proliferation" EXACT []
is_a: GO:0032944 ! regulation of mononuclear cell proliferation
is_a: GO:0070665 ! positive regulation of leukocyte proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032943 ! mononuclear cell proliferation
relationship: positively_regulates GO:0032943 ! mononuclear cell proliferation

[Term]
id: GO:0032947
name: protein complex scaffold
namespace: molecular_function
def: "Functions to provide a physical support for the assembly of a multiprotein complex." [GOC:mah]
is_a: GO:0005198 ! structural molecule activity
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0032948
name: regulation of alpha-glucan metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving alpha-glucans." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of alpha-glucan metabolism" EXACT []
is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process
is_a: GO:0032881 ! regulation of polysaccharide metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030978 ! alpha-glucan metabolic process
relationship: regulates GO:0030978 ! alpha-glucan metabolic process

[Term]
id: GO:0032949
name: regulation of alpha-glucan biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways relusting in the formation of alpha-glucans." [GOC:mah]
synonym: "regulation of alpha-glucan anabolism" EXACT []
synonym: "regulation of alpha-glucan biosynthesis" EXACT []
synonym: "regulation of alpha-glucan formation" EXACT []
synonym: "regulation of alpha-glucan synthesis" EXACT []
is_a: GO:0010962 ! regulation of glucan biosynthetic process
is_a: GO:0032948 ! regulation of alpha-glucan metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030979 ! alpha-glucan biosynthetic process
relationship: regulates GO:0030979 ! alpha-glucan biosynthetic process

[Term]
id: GO:0032950
name: regulation of beta-glucan metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving beta-glucans." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of beta-glucan metabolism" EXACT []
is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process
is_a: GO:0032881 ! regulation of polysaccharide metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051273 ! beta-glucan metabolic process
relationship: regulates GO:0051273 ! beta-glucan metabolic process

[Term]
id: GO:0032951
name: regulation of beta-glucan biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways relusting in the formation of beta-glucans." [GOC:mah]
synonym: "regulation of beta-glucan anabolism" EXACT []
synonym: "regulation of beta-glucan biosynthesis" EXACT []
synonym: "regulation of beta-glucan formation" EXACT []
synonym: "regulation of beta-glucan synthesis" EXACT []
is_a: GO:0010962 ! regulation of glucan biosynthetic process
is_a: GO:0032950 ! regulation of beta-glucan metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051274 ! beta-glucan biosynthetic process
relationship: regulates GO:0051274 ! beta-glucan biosynthetic process

[Term]
id: GO:0032952
name: regulation of (1->3)-beta-D-glucan metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving (1->3)-beta-D-glucans." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of (1->3)-beta-D-glucan metabolism" EXACT []
synonym: "regulation of 1,3-beta-D-glucan metabolic process" EXACT []
synonym: "regulation of 1,3-beta-glucan metabolic process" BROAD []
synonym: "regulation of 1,3-beta-glucan metabolism" EXACT []
is_a: GO:0032950 ! regulation of beta-glucan metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006074 ! (1->3)-beta-D-glucan metabolic process
relationship: regulates GO:0006074 ! (1->3)-beta-D-glucan metabolic process

[Term]
id: GO:0032953
name: regulation of (1->3)-beta-D-glucan biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans." [GOC:mah]
synonym: "regulation of 1,3-beta-glucan anabolism" EXACT []
synonym: "regulation of 1,3-beta-glucan biosynthesis" EXACT []
synonym: "regulation of 1,3-beta-glucan biosynthetic process" BROAD []
synonym: "regulation of 1,3-beta-glucan formation" EXACT []
synonym: "regulation of 1,3-beta-glucan synthesis" EXACT []
is_a: GO:0032951 ! regulation of beta-glucan biosynthetic process
is_a: GO:0032952 ! regulation of (1->3)-beta-D-glucan metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006075 ! (1->3)-beta-D-glucan biosynthetic process
relationship: regulates GO:0006075 ! (1->3)-beta-D-glucan biosynthetic process

[Term]
id: GO:0032954
name: regulation of cytokinetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a cytokinetic process." [GOC:mah]
subset: gosubset_prok
is_a: GO:0032465 ! regulation of cytokinesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032506 ! cytokinetic process
relationship: regulates GO:0032506 ! cytokinetic process

[Term]
id: GO:0032955
name: regulation of barrier septum assembly
namespace: biological_process
alt_id: GO:1901138
alt_id: GO:1902468
def: "Any process that modulates the frequency, rate or extent of barrier septum formation. Barrier septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis." [GOC:mtg_cell_cycle, PMID:19959363, PMID:21246752, PMID:22786806]
synonym: "regulation of barrier septum assembly involved in cell cycle cytokinesis" EXACT []
synonym: "regulation of barrier septum formation" EXACT []
synonym: "regulation of barrier septum formation involved in cell cycle cytokinesis" EXACT [GOC:TermGenie]
synonym: "regulation of barrier septum formation involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "regulation of formation of barrier septum involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "regulation of mitotic barrier septum assembly" EXACT []
synonym: "regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "regulation of septin assembly and septum formation involved in mitotic cell cycle" RELATED [GOC:TermGenie]
is_a: GO:1901891 ! regulation of cell septum assembly
is_a: GO:1903436 ! regulation of mitotic cytokinetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000917 ! barrier septum assembly
relationship: regulates GO:0000917 ! barrier septum assembly

[Term]
id: GO:0032956
name: regulation of actin cytoskeleton organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:mah]
synonym: "regulation of actin cytoskeleton organisation" EXACT [GOC:mah]
synonym: "regulation of actin cytoskeleton organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0032970 ! regulation of actin filament-based process
is_a: GO:0051493 ! regulation of cytoskeleton organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030036 ! actin cytoskeleton organization
relationship: regulates GO:0030036 ! actin cytoskeleton organization

[Term]
id: GO:0032957
name: inositol trisphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving myo-inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached." [CHEBI:24540, CHEBI:24848, GOC:mah]
synonym: "inositol trisphosphate metabolism" EXACT []
synonym: "IP3 metabolic process" EXACT []
synonym: "IP3 metabolism" EXACT []
synonym: "myo-inositol trisphosphate metabolic process" NARROW []
is_a: GO:0043647 ! inositol phosphate metabolic process

[Term]
id: GO:0032958
name: inositol phosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [CHEBI:24848, CHEBI:25448, GOC:mah]
synonym: "inositol phosphate anabolism" EXACT []
synonym: "inositol phosphate biosynthesis" EXACT []
synonym: "inositol phosphate formation" EXACT []
synonym: "inositol phosphate synthesis" EXACT []
synonym: "myo-inositol phosphate biosynthetic process" NARROW []
is_a: GO:0043647 ! inositol phosphate metabolic process
is_a: GO:0046173 ! polyol biosynthetic process
is_a: GO:0090407 ! organophosphate biosynthetic process

[Term]
id: GO:0032959
name: inositol trisphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of inositol trisphosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached." [CHEBI:24848, CHEBI:25450, GOC:mah]
synonym: "inositol trisphosphate anabolism" EXACT []
synonym: "inositol trisphosphate biosynthesis" EXACT []
synonym: "inositol trisphosphate formation" EXACT []
synonym: "inositol trisphosphate synthesis" EXACT []
synonym: "IP3 biosynthesis" EXACT []
synonym: "IP3 biosynthetic process" EXACT []
synonym: "myo-inositol trisphosphate biosynthetic process" NARROW []
is_a: GO:0032957 ! inositol trisphosphate metabolic process
is_a: GO:0032958 ! inositol phosphate biosynthetic process

[Term]
id: GO:0032960
name: regulation of inositol trisphosphate biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of inositol trisphosphate." [GOC:mah]
synonym: "regulation of inositol trisphosphate anabolism" EXACT []
synonym: "regulation of inositol trisphosphate biosynthesis" EXACT []
synonym: "regulation of inositol trisphosphate formation" EXACT []
synonym: "regulation of inositol trisphosphate synthesis" EXACT []
synonym: "regulation of IP3 biosynthesis" EXACT []
synonym: "regulation of IP3 biosynthetic process" EXACT []
synonym: "regulation of myo-inositol trisphosphate biosynthesis" NARROW []
synonym: "regulation of myo-inositol trisphosphate biosynthetic process" NARROW []
is_a: GO:0010919 ! regulation of inositol phosphate biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032959 ! inositol trisphosphate biosynthetic process
relationship: regulates GO:0032959 ! inositol trisphosphate biosynthetic process

[Term]
id: GO:0032961
name: negative regulation of inositol trisphosphate biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of inositol trisphosphate." [GOC:mah]
synonym: "negative regulation of inositol trisphosphate anabolism" EXACT []
synonym: "negative regulation of inositol trisphosphate biosynthesis" EXACT []
synonym: "negative regulation of inositol trisphosphate formation" EXACT []
synonym: "negative regulation of inositol trisphosphate synthesis" EXACT []
synonym: "negative regulation of IP3 biosynthesis" EXACT []
synonym: "negative regulation of IP3 biosynthetic process" EXACT []
synonym: "negative regulation of myo-inositol trisphosphate biosynthesis" NARROW []
synonym: "negative regulation of myo-inositol trisphosphate biosynthetic process" NARROW []
is_a: GO:0010920 ! negative regulation of inositol phosphate biosynthetic process
is_a: GO:0032960 ! regulation of inositol trisphosphate biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032959 ! inositol trisphosphate biosynthetic process
relationship: negatively_regulates GO:0032959 ! inositol trisphosphate biosynthetic process

[Term]
id: GO:0032962
name: positive regulation of inositol trisphosphate biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of inositol trisphosphate." [GOC:mah]
synonym: "positive regulation of inositol trisphosphate anabolism" EXACT []
synonym: "positive regulation of inositol trisphosphate biosynthesis" EXACT []
synonym: "positive regulation of inositol trisphosphate formation" EXACT []
synonym: "positive regulation of inositol trisphosphate synthesis" EXACT []
synonym: "positive regulation of IP3 biosynthesis" EXACT []
synonym: "positive regulation of IP3 biosynthetic process" EXACT []
synonym: "positive regulation of myo-inositol trisphosphate biosynthesis" NARROW []
synonym: "positive regulation of myo-inositol trisphosphate biosynthetic process" NARROW []
is_a: GO:0032960 ! regulation of inositol trisphosphate biosynthetic process
is_a: GO:0060732 ! positive regulation of inositol phosphate biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032959 ! inositol trisphosphate biosynthetic process
relationship: positively_regulates GO:0032959 ! inositol trisphosphate biosynthetic process

[Term]
id: GO:0032963
name: collagen metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%)." [GOC:mah, ISBN:0198506732]
synonym: "collagen metabolism" EXACT []
is_a: GO:0044259 ! multicellular organismal macromolecule metabolic process

[Term]
id: GO:0032964
name: collagen biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%)." [GOC:mah, ISBN:0198506732]
synonym: "collagen anabolism" EXACT []
synonym: "collagen biosynthesis" EXACT []
synonym: "collagen formation" EXACT []
synonym: "collagen synthesis" EXACT []
is_a: GO:0009059 ! macromolecule biosynthetic process
is_a: GO:0032963 ! collagen metabolic process
is_a: GO:0044711 ! single-organism biosynthetic process

[Term]
id: GO:0032965
name: regulation of collagen biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:mah]
synonym: "regulation of collagen anabolism" EXACT []
synonym: "regulation of collagen biosynthesis" EXACT []
synonym: "regulation of collagen formation" EXACT []
synonym: "regulation of collagen synthesis" EXACT []
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
is_a: GO:0010712 ! regulation of collagen metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032964 ! collagen biosynthetic process
relationship: regulates GO:0032964 ! collagen biosynthetic process

[Term]
id: GO:0032966
name: negative regulation of collagen biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:mah]
synonym: "negative regulation of collagen anabolism" EXACT []
synonym: "negative regulation of collagen biosynthesis" EXACT []
synonym: "negative regulation of collagen formation" EXACT []
synonym: "negative regulation of collagen synthesis" EXACT []
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
is_a: GO:0010713 ! negative regulation of collagen metabolic process
is_a: GO:0032965 ! regulation of collagen biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032964 ! collagen biosynthetic process
relationship: negatively_regulates GO:0032964 ! collagen biosynthetic process

[Term]
id: GO:0032967
name: positive regulation of collagen biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:mah]
synonym: "positive regulation of collagen anabolism" EXACT []
synonym: "positive regulation of collagen biosynthesis" EXACT []
synonym: "positive regulation of collagen formation" EXACT []
synonym: "positive regulation of collagen synthesis" EXACT []
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0010714 ! positive regulation of collagen metabolic process
is_a: GO:0032965 ! regulation of collagen biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032964 ! collagen biosynthetic process
relationship: positively_regulates GO:0032964 ! collagen biosynthetic process

[Term]
id: GO:0032968
name: positive regulation of transcription elongation from RNA polymerase II promoter
namespace: biological_process
alt_id: GO:0090040
def: "Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH]
synonym: "positive regulation of gene-specific transcription elongation from RNA polymerase II promoter" RELATED []
synonym: "positive regulation of RNA elongation from RNA polymerase II promoter" EXACT []
is_a: GO:0032786 ! positive regulation of DNA-templated transcription, elongation
is_a: GO:0034243 ! regulation of transcription elongation from RNA polymerase II promoter
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006368 ! transcription elongation from RNA polymerase II promoter
relationship: positively_regulates GO:0006368 ! transcription elongation from RNA polymerase II promoter

[Term]
id: GO:0032969
name: endosomal scaffold complex
namespace: cellular_component
def: "A protein complex that contains MAPKSP1 (MP1, Map2k1ip1) and ROBLD3 (p14, Mapbpip), is anchored to late endosomes, and is involved in selective activation of the ERK1 in ERK/MAPK signaling." [PMID:15263099, PMID:16227978, PMID:17496910]
synonym: "endosomal adaptor complex" EXACT [GOC:hjd]
synonym: "MP1-p14 scaffolding complex" EXACT [GOC:mah]
is_a: GO:0044440 ! endosomal part
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0031902 ! late endosome membrane

[Term]
id: GO:0032970
name: regulation of actin filament-based process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the actin cytoskeleton." [GOC:mah]
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030029 ! actin filament-based process
relationship: regulates GO:0030029 ! actin filament-based process

[Term]
id: GO:0032971
name: regulation of muscle filament sliding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of muscle filament sliding." [GOC:ecd]
is_a: GO:0006937 ! regulation of muscle contraction
is_a: GO:0032386 ! regulation of intracellular transport
is_a: GO:1903115 ! regulation of actin filament-based movement
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030049 ! muscle filament sliding
relationship: regulates GO:0030049 ! muscle filament sliding

[Term]
id: GO:0032972
name: regulation of muscle filament sliding speed
namespace: biological_process
def: "Any process that modulates the velocity of muscle filament sliding." [GOC:dph, GOC:ecd, GOC:tb]
is_a: GO:0032971 ! regulation of muscle filament sliding
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0032973
name: amino acid export
namespace: biological_process
def: "The directed movement of amino acids out of a cell or organelle." [GOC:mah]
synonym: "amino acid efflux" EXACT []
is_a: GO:0006865 ! amino acid transport

[Term]
id: GO:0032974
name: amino acid transmembrane export from vacuole
namespace: biological_process
def: "The directed movement of amino acids out of the vacuole, across the vacuolar membrane." [GOC:mah]
synonym: "amino acid efflux from vacuole" EXACT []
synonym: "vacuolar amino acid export" EXACT []
is_a: GO:0034487 ! vacuolar amino acid transmembrane transport
is_a: GO:0044746 ! amino acid transmembrane export

[Term]
id: GO:0032975
name: amino acid transmembrane import into vacuole
namespace: biological_process
def: "The directed movement of amino acids into the vacuole across the vacuolar membrane." [GOC:mah]
synonym: "vacuolar amino acid import" EXACT []
is_a: GO:0034487 ! vacuolar amino acid transmembrane transport
is_a: GO:0044745 ! amino acid transmembrane import

[Term]
id: GO:0032976
name: release of matrix enzymes from mitochondria
namespace: biological_process
def: "The process in which enzymes, such as aspartate aminotransferase, are enabled to move from the mitochondrial matrix into the cytosol, as part of the apoptotic process." [GOC:mah, GOC:mtg_apoptosis, PMID:9843949]
comment: Annotation to this term should be done with caution, particularly if the mechanism is not well clarified.
synonym: "mAST release from mitochondria" NARROW []
synonym: "release of aspartate aminotransferase from mitochondria" NARROW []
is_a: GO:0008637 ! apoptotic mitochondrial changes

[Term]
id: GO:0032977
name: membrane insertase activity
namespace: molecular_function
def: "Mediates the integration of proteins into a membrane from the inner side of the membrane. Membrane insertases are highly conserved and include the bacterial YidC family, the plant chloroplast Alb3 family, and the fungal and animal mitochondrial Oxa1/Cox18 family." [PMID:14739936]
subset: gosubset_prok
is_a: GO:0008565 ! protein transporter activity

[Term]
id: GO:0032978
name: protein insertion into membrane from inner side
namespace: biological_process
def: "The process in which a protein is incorporated into a lipid bilayer, e.g., the prokaryotic, mitochondrial, or chloroplast inner membrane, from the inner side." [PMID:14739936, PMID:15473843]
synonym: "insertion of proteins into membrane from the inner side" EXACT []
is_a: GO:0051205 ! protein insertion into membrane

[Term]
id: GO:0032979
name: protein insertion into mitochondrial membrane from inner side
namespace: biological_process
def: "The process in which a protein is incorporated into the mitochondrial membrane from the inner side. This includes membrane insertion of newly synthesized mitochondrially-encoded proteins, and insertion of nuclear-encoded proteins after their import into the mitochondrial matrix." [PMID:12880202, PMID:15473843]
synonym: "insertion of proteins into the mitochondrial membrane from the inner side" EXACT []
is_a: GO:0032978 ! protein insertion into membrane from inner side
is_a: GO:0051204 ! protein insertion into mitochondrial membrane

[Term]
id: GO:0032980
name: keratinocyte activation
namespace: biological_process
def: "A change in the morphology or behavior of a keratinocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. Upon activation, keratinocytes become migratory and hyperproliferative, and produce growth factors and cytokines." [GOC:mah, PMID:15737202]
is_a: GO:0001775 ! cell activation

[Term]
id: GO:0032981
name: mitochondrial respiratory chain complex I assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I." [GOC:rph]
synonym: "mitochondrial complex I assembly" EXACT []
synonym: "mitochondrial NADH dehydrogenase complex (ubiquinone) assembly" EXACT []
is_a: GO:0010257 ! NADH dehydrogenase complex assembly
is_a: GO:0033108 ! mitochondrial respiratory chain complex assembly
is_a: GO:0097031 ! mitochondrial respiratory chain complex I biogenesis

[Term]
id: GO:0032982
name: myosin filament
namespace: cellular_component
def: "A protein complex containing myosin heavy chains, plus associated light chains and other proteins, in which the myosin heavy chains are arranged into a filament." [GOC:mah]
synonym: "myosin thick filament" RELATED []
synonym: "thick filament" RELATED []
is_a: GO:0016459 ! myosin complex

[Term]
id: GO:0032983
name: kainate selective glutamate receptor complex
namespace: cellular_component
def: "An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. Kainate receptors are multimeric assemblies of GluK1-3 (also called GluR5-7), GluK4 (KA1) and GluK5 (KA2) subunits." [GOC:bf, http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html, PMID:18655795]
is_a: GO:0008328 ! ionotropic glutamate receptor complex

[Term]
id: GO:0032984
name: macromolecular complex disassembly
namespace: biological_process
alt_id: GO:0034623
def: "The disaggregation of a macromolecular complex into its constituent components." [GOC:mah]
subset: gosubset_prok
synonym: "cellular macromolecular complex disassembly" EXACT []
synonym: "cellular macromolecule complex disassembly" EXACT []
synonym: "macromolecule complex disassembly" EXACT []
is_a: GO:0022411 ! cellular component disassembly
is_a: GO:0043933 ! macromolecular complex subunit organization

[Term]
id: GO:0032985
name: protein-carbohydrate complex disassembly
namespace: biological_process
def: "The disaggregation of a protein-carbohydrate complex into its constituent components." [GOC:mah]
is_a: GO:0032984 ! macromolecular complex disassembly
is_a: GO:0071823 ! protein-carbohydrate complex subunit organization

[Term]
id: GO:0032986
name: protein-DNA complex disassembly
namespace: biological_process
def: "The disaggregation of a protein-DNA complex into its constituent components." [GOC:mah]
synonym: "DNA-protein complex disassembly" EXACT [GOC:mah]
is_a: GO:0032984 ! macromolecular complex disassembly
is_a: GO:0071824 ! protein-DNA complex subunit organization

[Term]
id: GO:0032987
name: protein-lipid complex disassembly
namespace: biological_process
def: "The disaggregation of a protein-lipid complex into its constituent components." [GOC:mah]
is_a: GO:0032984 ! macromolecular complex disassembly
is_a: GO:0071825 ! protein-lipid complex subunit organization

[Term]
id: GO:0032988
name: ribonucleoprotein complex disassembly
namespace: biological_process
def: "The disaggregation of a protein-RNA complex into its constituent components." [GOC:mah]
synonym: "protein-RNA complex disassembly" EXACT []
synonym: "RNA-protein complex disassembly" EXACT []
synonym: "RNP complex disassembly" EXACT []
is_a: GO:0032984 ! macromolecular complex disassembly
is_a: GO:0071826 ! ribonucleoprotein complex subunit organization

[Term]
id: GO:0032989
name: cellular component morphogenesis
namespace: biological_process
def: "The process in which cellular structures, including whole cells or cell parts, are generated and organized." [GOC:dph, GOC:mah, GOC:tb]
subset: goslim_pir
subset: gosubset_prok
synonym: "cellular structure morphogenesis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0016043 ! cellular component organization
is_a: GO:0048869 ! cellular developmental process

[Term]
id: GO:0032990
name: cell part morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a cell part are generated and organized." [GOC:mah]
is_a: GO:0032989 ! cellular component morphogenesis

[Term]
id: GO:0032991
name: macromolecular complex
namespace: cellular_component
def: "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together." [GOC:mah]
subset: goslim_pir
subset: gosubset_prok
synonym: "macromolecule complex" EXACT []
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0032992
name: protein-carbohydrate complex
namespace: cellular_component
def: "A macromolecular complex containing separate protein and carbohydrate molecules.  Separate in this context means not covalently bound to each other." [GOC:mah]
comment: Macromolecular complexes in which the carbohydrate component is all covalently bound to protein are not considered protein carbohydrate complexes.
subset: gosubset_prok
is_a: GO:0032991 ! macromolecular complex

[Term]
id: GO:0032993
name: protein-DNA complex
namespace: cellular_component
def: "A macromolecular complex containing both protein and DNA molecules." [GOC:mah]
comment: Note that this term is intended to classify complexes that have DNA as one of the members of the complex, that is, the complex does not exist if DNA is not present. Protein complexes that interact with DNA e.g. transcription factor complexes should not be classified here.
subset: gosubset_prok
synonym: "DNA-protein complex" EXACT [GOC:mah]
is_a: GO:0032991 ! macromolecular complex

[Term]
id: GO:0032994
name: protein-lipid complex
namespace: cellular_component
def: "A macromolecular complex containing separate protein and lipid molecules.  Separate in this context means not covalently bound to each other." [GOC:mah]
comment: Macromolecular complexes in which the lipid component is all covalently bound to protein are not considered protein-lipid complexes.
subset: gosubset_prok
is_a: GO:0032991 ! macromolecular complex

[Term]
id: GO:0032995
name: regulation of fungal-type cell wall biogenesis
namespace: biological_process
def: "Any process that modulates the process in which a cell wall is synthesized, aggregates, and bonds together. The fungal-type cell wall contains beta-glucan and may contain chitin." [GOC:dph, GOC:mah, GOC:tb]
synonym: "regulation of chitin- and beta-glucan-containing cell wall biogenesis" RELATED [GOC:mah]
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:1903338 ! regulation of cell wall organization or biogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009272 ! fungal-type cell wall biogenesis
relationship: regulates GO:0009272 ! fungal-type cell wall biogenesis

[Term]
id: GO:0032996
name: Bcl3-Bcl10 complex
namespace: cellular_component
def: "A protein complex containing Bcl3 and Bcl10, which forms when Akt1 is activated by TNF-alpha to phosphorylate Bcl10; the Bcl3-Bcl10 complex is translocated to the nucleus." [PMID:16280327]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0032997
name: Fc receptor complex
namespace: cellular_component
def: "A protein complex composed of a subunit or subunits capable of binding the Fc portion of an immunoglobulin with additional signaling components. The complex functions as a receptor for immunoglobulin." [GOC:add, ISBN:0781735149]
subset: goslim_pir
synonym: "Fc-receptor complex" EXACT []
synonym: "FcR complex" EXACT []
synonym: "immunoglobulin receptor complex" BROAD []
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0032998
name: Fc-epsilon receptor I complex
namespace: cellular_component
def: "A protein complex composed of an Fc-epsilon RI alpha chain and an Fc-epsilon RI gamma chain dimer with or without an Fc-episilon RI beta chain and additional signaling components. The complex functions primarily as an activating receptor for IgE." [GOC:add, ISBN:0781735149]
synonym: "FceRI complex" EXACT []
synonym: "IgE receptor complex" BROAD []
synonym: "immunoglobulin E receptor complex" BROAD []
is_a: GO:0032997 ! Fc receptor complex

[Term]
id: GO:0032999
name: Fc-alpha receptor I complex
namespace: cellular_component
def: "A protein complex composed of an Fc-alpha R alpha chain and an Fc-epsilon RI gamma chain dimer with or without additional signaling components. The complex functions primarily as an activating receptor for IgA." [GOC:add, ISBN:0781735149, PMID:12524384]
synonym: "FcaRI complex" EXACT []
synonym: "IgA receptor complex" BROAD []
synonym: "immunoglobulin A receptor complex" BROAD []
is_a: GO:0032997 ! Fc receptor complex

[Term]
id: GO:0033000
name: Fc-gamma receptor I complex
namespace: cellular_component
def: "A protein complex composed of an Fc-gamma RI alpha chain and an Fc-epsilon RI gamma chain dimer with or without additional signaling components. The complex functions primarily as an activating receptor for IgG." [GOC:add, ISBN:0781735149, PMID:11244038, PMID:12413532]
synonym: "FcgRI complex" EXACT []
synonym: "IgG receptor complex" BROAD []
synonym: "immunoglobulin G receptor complex" BROAD []
is_a: GO:0032997 ! Fc receptor complex

[Term]
id: GO:0033001
name: Fc-gamma receptor III complex
namespace: cellular_component
def: "A protein complex composed of an Fc-gamma RIII alpha chain and an Fc-epsilon RI gamma chain dimer with or without an Fc-epsilon RI beta chain and additional signaling components. The complex functions primarily as an activating receptor for IgG." [GOC:add, ISBN:0781735149, PMID:11244038, PMID:12413532]
synonym: "FcgRIII complex" EXACT []
synonym: "IgG receptor complex" BROAD []
synonym: "immunoglobulin G receptor complex" BROAD []
is_a: GO:0032997 ! Fc receptor complex

[Term]
id: GO:0033002
name: muscle cell proliferation
namespace: biological_process
def: "The expansion of a muscle cell population by cell division." [CL:0000187, GOC:mah]
synonym: "myocyte proliferation" EXACT []
is_a: GO:0008283 ! cell proliferation

[Term]
id: GO:0033003
name: regulation of mast cell activation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of mast cell activation." [GOC:mah]
is_a: GO:0002694 ! regulation of leukocyte activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045576 ! mast cell activation
relationship: regulates GO:0045576 ! mast cell activation

[Term]
id: GO:0033004
name: negative regulation of mast cell activation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell activation." [GOC:mah]
is_a: GO:0002695 ! negative regulation of leukocyte activation
is_a: GO:0033003 ! regulation of mast cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045576 ! mast cell activation
relationship: negatively_regulates GO:0045576 ! mast cell activation

[Term]
id: GO:0033005
name: positive regulation of mast cell activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of mast cell activation." [GOC:mah]
is_a: GO:0002696 ! positive regulation of leukocyte activation
is_a: GO:0033003 ! regulation of mast cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045576 ! mast cell activation
relationship: positively_regulates GO:0045576 ! mast cell activation

[Term]
id: GO:0033006
name: regulation of mast cell activation involved in immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of mast cell activation as part of an immune response." [GOC:mah]
synonym: "regulation of mast cell activation during immune response" RELATED [GOC:tb]
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0033003 ! regulation of mast cell activation
is_a: GO:0050776 ! regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002279 ! mast cell activation involved in immune response
relationship: regulates GO:0002279 ! mast cell activation involved in immune response

[Term]
id: GO:0033007
name: negative regulation of mast cell activation involved in immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell activation as part of an immune response." [GOC:mah]
synonym: "negative regulation of mast cell activation during immune response" RELATED [GOC:tb]
is_a: GO:0002698 ! negative regulation of immune effector process
is_a: GO:0033004 ! negative regulation of mast cell activation
is_a: GO:0033006 ! regulation of mast cell activation involved in immune response
is_a: GO:0050777 ! negative regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002279 ! mast cell activation involved in immune response
relationship: negatively_regulates GO:0002279 ! mast cell activation involved in immune response

[Term]
id: GO:0033008
name: positive regulation of mast cell activation involved in immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of mast cell activation as part of an immune response." [GOC:mah]
synonym: "positive regulation of mast cell activation during immune response" RELATED [GOC:tb]
is_a: GO:0033005 ! positive regulation of mast cell activation
is_a: GO:0033006 ! regulation of mast cell activation involved in immune response
is_a: GO:0050778 ! positive regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002279 ! mast cell activation involved in immune response
relationship: positively_regulates GO:0002279 ! mast cell activation involved in immune response

[Term]
id: GO:0033009
name: nucleomorph
namespace: cellular_component
def: "A small, vestigial nucleus found in some plastids that derive from a eukaryotic endosymbiont. Observed in chlorarachniophytes and cryptomonads, which acquired their plastids from a green and red alga respectively." [PMID:16760254]
xref: Wikipedia:Nucleomorph
is_a: GO:0043231 ! intracellular membrane-bounded organelle
is_a: GO:0044435 ! plastid part

[Term]
id: GO:0033010
name: paranodal junction
namespace: cellular_component
def: "A highly specialized cell-cell junction found in vertebrates, which forms between a neuron and a glial cell, and has structural similarity to Drosophila septate junctions. It flanks the node of Ranvier in myelinated nerve and electrically isolates the myelinated from unmyelinated nerve segments and physically separates the voltage-gated sodium channels at the node from the cluster of potassium channels underneath the myelin sheath." [PMID:11395001, PMID:14630217]
synonym: "axoglial septate junction" EXACT [MP:0010735]
synonym: "paranodal axoglial junction" EXACT [PMID:18803321]
synonym: "paranodal septate junction" EXACT [MP:0010735]
is_a: GO:0005911 ! cell-cell junction

[Term]
id: GO:0033011
name: perinuclear theca
namespace: cellular_component
def: "A condensed cytoplasmic structure that covers the nucleus of mammalian spermatozoa except for a narrow zone around the insertion of the tail. It shows two distinct regions, a subacrosomal layer and, continuing caudally beyond the acrosomic system, the postacrosomal sheath. The perinuclear theca has been considered a cytoskeletal scaffold responsible for maintaining the overall architecture of the mature sperm head; however, recent studies indicate that the bulk of its constituent proteins are not traditional cytoskeletal proteins but rather a variety of cytosolic proteins." [PMID:17289678, PMID:8025156]
is_a: GO:0005856 ! cytoskeleton
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0048471 ! perinuclear region of cytoplasm

[Term]
id: GO:0033012
name: porosome
namespace: cellular_component
def: "A permanent cup-shaped structure at the cell plasma membrane in secretory cells. Following a secretory stimulus, secretory vesicles transiently dock and fuse at the base of porosomes and release intravesicular contents dictated by the turgor pressure generated from the swelling of secretory vesicles." [PMID:15090256, PMID:16563225]
xref: Wikipedia:Porosome
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0033013
name: tetrapyrrole metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [CHEBI:26932, GOC:mah]
synonym: "tetrapyrrole metabolism" EXACT []
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process

[Term]
id: GO:0033014
name: tetrapyrrole biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [CHEBI:26932, GOC:mah]
synonym: "tetrapyrrole anabolism" EXACT []
synonym: "tetrapyrrole biosynthesis" EXACT []
synonym: "tetrapyrrole formation" EXACT []
synonym: "tetrapyrrole synthesis" EXACT []
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0033013 ! tetrapyrrole metabolic process
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process

[Term]
id: GO:0033015
name: tetrapyrrole catabolic process
namespace: biological_process
def: "The chemical reactions and pathways leading to the breakdown of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [CHEBI:26932, GOC:mah]
synonym: "tetrapyrrole breakdown" EXACT []
synonym: "tetrapyrrole catabolism" EXACT []
synonym: "tetrapyrrole degradation" EXACT []
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0033013 ! tetrapyrrole metabolic process
is_a: GO:0044270 ! cellular nitrogen compound catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process

[Term]
id: GO:0033016
name: rhoptry membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a rhoptry." [GOC:mah]
is_a: GO:0031090 ! organelle membrane
is_a: GO:0044464 ! cell part
relationship: part_of GO:0020008 ! rhoptry

[Term]
id: GO:0033017
name: sarcoplasmic reticulum membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the sarcoplasmic reticulum." [GOC:rph]
is_a: GO:0005789 ! endoplasmic reticulum membrane
relationship: part_of GO:0016529 ! sarcoplasmic reticulum

[Term]
id: GO:0033018
name: sarcoplasmic reticulum lumen
namespace: cellular_component
def: "The volume enclosed by the membranes of the sarcoplasmic reticulum." [GOC:rph]
is_a: GO:0005788 ! endoplasmic reticulum lumen
relationship: part_of GO:0016529 ! sarcoplasmic reticulum

[Term]
id: GO:0033019
name: 5-hydroxyvalerate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-hydroxyvalerate + NAD+ = 5-oxovalerate + NADH." [GOC:mlg, PMID:12406764]
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033020
name: cyclopentanol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cyclopentanol." [GOC:mlg, PMID:12406764]
subset: gosubset_prok
synonym: "cyclopentanol metabolism" EXACT []
is_a: GO:0006066 ! alcohol metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process

[Term]
id: GO:0033021
name: cyclopentanol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cyclopentanol." [GOC:mah, PMID:12406764]
subset: gosubset_prok
synonym: "cyclopentanol anabolism" EXACT []
synonym: "cyclopentanol biosynthesis" EXACT []
synonym: "cyclopentanol formation" EXACT []
synonym: "cyclopentanol synthesis" EXACT []
is_a: GO:0033020 ! cyclopentanol metabolic process
is_a: GO:0046165 ! alcohol biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process

[Term]
id: GO:0033022
name: cyclopentanol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cyclopentanol." [GOC:mah, PMID:12406764]
subset: gosubset_prok
synonym: "cyclopentanol breakdown" EXACT []
synonym: "cyclopentanol catabolism" EXACT []
synonym: "cyclopentanol degradation" EXACT []
is_a: GO:0033020 ! cyclopentanol metabolic process
is_a: GO:0046164 ! alcohol catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process

[Term]
id: GO:0033023
name: mast cell homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of mast cells such that the total number of mast cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, PMID:11292031]
comment: Note that this term represents the return of mast cell levels to stable numbers following an immune response as well as the proliferation and elimination of mast cells required to maintain stable numbers in the absence of an outside stimulus.
is_a: GO:0001776 ! leukocyte homeostasis
is_a: GO:0002262 ! myeloid cell homeostasis

[Term]
id: GO:0033024
name: mast cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a mast cell, a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation." [CL:0000097, GOC:add, GOC:mtg_apoptosis, PMID:11292031, PMID:12360215, PMID:16605130]
synonym: "apoptosis of mast cells" EXACT []
synonym: "mast cell apoptosis" NARROW []
is_a: GO:0033028 ! myeloid cell apoptotic process
is_a: GO:0071887 ! leukocyte apoptotic process
relationship: part_of GO:0033023 ! mast cell homeostasis

[Term]
id: GO:0033025
name: regulation of mast cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of mast cell apoptotic process." [GOC:add, GOC:mtg_apoptosis]
synonym: "regulation of mast cell apoptosis" NARROW []
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0032844 ! regulation of homeostatic process
is_a: GO:0033032 ! regulation of myeloid cell apoptotic process
is_a: GO:2000106 ! regulation of leukocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0033024 ! mast cell apoptotic process
relationship: regulates GO:0033024 ! mast cell apoptotic process

[Term]
id: GO:0033026
name: negative regulation of mast cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell apoptotic process." [GOC:add, GOC:mtg_apoptosis]
synonym: "down regulation of mast cell apoptosis" EXACT []
synonym: "down-regulation of mast cell apoptosis" EXACT []
synonym: "downregulation of mast cell apoptosis" EXACT []
synonym: "inhibition of mast cell apoptosis" NARROW []
synonym: "negative regulation of mast cell apoptosis" NARROW []
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0032845 ! negative regulation of homeostatic process
is_a: GO:0033025 ! regulation of mast cell apoptotic process
is_a: GO:0033033 ! negative regulation of myeloid cell apoptotic process
is_a: GO:2000107 ! negative regulation of leukocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0033024 ! mast cell apoptotic process
relationship: negatively_regulates GO:0033024 ! mast cell apoptotic process

[Term]
id: GO:0033027
name: positive regulation of mast cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of mast cell apoptotic process." [GOC:add, GOC:mtg_apoptosis]
synonym: "activation of mast cell apoptosis" NARROW []
synonym: "positive regulation of mast cell apoptosis" NARROW []
synonym: "stimulation of mast cell apoptosis" NARROW []
synonym: "up regulation of mast cell apoptosis" EXACT []
synonym: "up-regulation of mast cell apoptosis" EXACT []
synonym: "upregulation of mast cell apoptosis" EXACT []
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0032846 ! positive regulation of homeostatic process
is_a: GO:0033025 ! regulation of mast cell apoptotic process
is_a: GO:0033034 ! positive regulation of myeloid cell apoptotic process
is_a: GO:2000108 ! positive regulation of leukocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0033024 ! mast cell apoptotic process
relationship: positively_regulates GO:0033024 ! mast cell apoptotic process

[Term]
id: GO:0033028
name: myeloid cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a myeloid cell, a cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage." [CL:0000763, GOC:add, GOC:mtg_apoptosis, PMID:11292031, PMID:15330259, PMID:17133093]
synonym: "apoptosis of myeloid cells" EXACT []
synonym: "myeloid cell apoptosis" NARROW []
is_a: GO:0006915 ! apoptotic process

[Term]
id: GO:0033029
name: regulation of neutrophil apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of neutrophil apoptotic process." [GOC:add, GOC:mtg_apoptosis]
synonym: "regulation of neutrophil apoptosis" NARROW []
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0032844 ! regulation of homeostatic process
is_a: GO:0033032 ! regulation of myeloid cell apoptotic process
is_a: GO:2000106 ! regulation of leukocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001781 ! neutrophil apoptotic process
relationship: regulates GO:0001781 ! neutrophil apoptotic process

[Term]
id: GO:0033030
name: negative regulation of neutrophil apoptotic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of neutrophil apoptotic process." [GOC:add, GOC:mtg_apoptosis]
synonym: "down regulation of neutrophil apoptosis" EXACT []
synonym: "down-regulation of neutrophil apoptosis" EXACT []
synonym: "downregulation of neutrophil apoptosis" EXACT []
synonym: "inhibition of neutrophil apoptosis" NARROW []
synonym: "negative regulation of neutrophil apoptosis" NARROW []
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0032845 ! negative regulation of homeostatic process
is_a: GO:0033029 ! regulation of neutrophil apoptotic process
is_a: GO:0033033 ! negative regulation of myeloid cell apoptotic process
is_a: GO:2000107 ! negative regulation of leukocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001781 ! neutrophil apoptotic process
relationship: negatively_regulates GO:0001781 ! neutrophil apoptotic process

[Term]
id: GO:0033031
name: positive regulation of neutrophil apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of neutrophil apoptotic process." [GOC:add, GOC:mtg_apoptosis]
synonym: "activation of neutrophil apoptosis" NARROW []
synonym: "positive regulation of neutrophil apoptosis" NARROW []
synonym: "stimulation of neutrophil apoptosis" NARROW []
synonym: "up regulation of neutrophil apoptosis" EXACT []
synonym: "up-regulation of neutrophil apoptosis" EXACT []
synonym: "upregulation of neutrophil apoptosis" EXACT []
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0032846 ! positive regulation of homeostatic process
is_a: GO:0033029 ! regulation of neutrophil apoptotic process
is_a: GO:0033034 ! positive regulation of myeloid cell apoptotic process
is_a: GO:2000108 ! positive regulation of leukocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001781 ! neutrophil apoptotic process
relationship: positively_regulates GO:0001781 ! neutrophil apoptotic process

[Term]
id: GO:0033032
name: regulation of myeloid cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of myeloid cell apoptotic process." [GOC:add, GOC:mtg_apoptosis]
synonym: "regulation of myeloid cell apoptosis" NARROW []
is_a: GO:0042981 ! regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0033028 ! myeloid cell apoptotic process
relationship: regulates GO:0033028 ! myeloid cell apoptotic process

[Term]
id: GO:0033033
name: negative regulation of myeloid cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a myeloid cell apoptotic process." [GOC:add, GOC:mtg_apoptosis]
synonym: "down regulation of myeloid cell apoptosis" EXACT []
synonym: "down-regulation of myeloid cell apoptosis" EXACT []
synonym: "downregulation of myeloid cell apoptosis" EXACT []
synonym: "inhibition of myeloid cell apoptosis" NARROW []
synonym: "negative regulation of myeloid cell apoptosis" NARROW []
is_a: GO:0033032 ! regulation of myeloid cell apoptotic process
is_a: GO:0043066 ! negative regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0033028 ! myeloid cell apoptotic process
relationship: negatively_regulates GO:0033028 ! myeloid cell apoptotic process

[Term]
id: GO:0033034
name: positive regulation of myeloid cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of myeloid cell apoptotic process." [GOC:add, GOC:mtg_apoptosis]
synonym: "activation of myeloid cell apoptosis" NARROW []
synonym: "positive regulation of myeloid cell apoptosis" NARROW []
synonym: "stimulation of myeloid cell apoptosis" NARROW []
synonym: "up regulation of myeloid cell apoptosis" EXACT []
synonym: "up-regulation of myeloid cell apoptosis" EXACT []
synonym: "upregulation of myeloid cell apoptosis" EXACT []
is_a: GO:0033032 ! regulation of myeloid cell apoptotic process
is_a: GO:0043065 ! positive regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0033028 ! myeloid cell apoptotic process
relationship: positively_regulates GO:0033028 ! myeloid cell apoptotic process

[Term]
id: GO:0033036
name: macromolecule localization
namespace: biological_process
def: "Any process in which a macromolecule is transported to, or maintained in, a specific location." [GOC:mah]
subset: gosubset_prok
synonym: "macromolecule localisation" EXACT [GOC:mah]
is_a: GO:0051179 ! localization

[Term]
id: GO:0033037
name: polysaccharide localization
namespace: biological_process
def: "Any process in which a polysaccharide is transported to, or maintained in, a specific location." [GOC:mah]
subset: gosubset_prok
synonym: "polysaccharide localisation" EXACT [GOC:mah]
is_a: GO:0033036 ! macromolecule localization

[Term]
id: GO:0033038
name: bitter taste receptor activity
namespace: molecular_function
def: "Combining with soluble bitter compounds to initiate a change in cell activity. These receptors are responsible for the sense of bitter taste." [GOC:mah]
is_a: GO:0008527 ! taste receptor activity
relationship: part_of GO:0001580 ! detection of chemical stimulus involved in sensory perception of bitter taste

[Term]
id: GO:0033039
name: salty taste receptor activity
namespace: molecular_function
def: "Combining with soluble salty compounds to initiate a change in cell activity. These receptors are responsible for the sense of salty taste." [GOC:mah]
is_a: GO:0008527 ! taste receptor activity
relationship: part_of GO:0001583 ! detection of chemical stimulus involved in sensory perception of salty taste

[Term]
id: GO:0033040
name: sour taste receptor activity
namespace: molecular_function
def: "Combining with soluble sour compounds to initiate a change in cell activity. These receptors are responsible for the sense of sour taste." [GOC:mah]
is_a: GO:0008527 ! taste receptor activity
relationship: part_of GO:0001581 ! detection of chemical stimulus involved in sensory perception of sour taste

[Term]
id: GO:0033041
name: sweet taste receptor activity
namespace: molecular_function
def: "Combining with soluble sweet compounds to initiate a change in cell activity. These receptors are responsible for the sense of sweet taste." [GOC:mah]
is_a: GO:0008527 ! taste receptor activity
relationship: part_of GO:0001582 ! detection of chemical stimulus involved in sensory perception of sweet taste

[Term]
id: GO:0033042
name: umami taste receptor activity
namespace: molecular_function
def: "Combining with soluble umami compounds to initiate a change in cell activity. These receptors are responsible for the sense of umami taste, the savory taste of meats and other foods that are rich in glutamates." [GOC:mah]
is_a: GO:0008527 ! taste receptor activity
relationship: part_of GO:0046535 ! detection of chemical stimulus involved in sensory perception of umami taste

[Term]
id: GO:0033043
name: regulation of organelle organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:mah]
subset: goslim_yeast
synonym: "regulation of organelle organisation" EXACT [GOC:mah]
synonym: "regulation of organelle organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006996 ! organelle organization
relationship: regulates GO:0006996 ! organelle organization

[Term]
id: GO:0033044
name: regulation of chromosome organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome." [GOC:mah]
synonym: "regulation of chromosome organisation" EXACT [GOC:mah]
synonym: "regulation of chromosome organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0033043 ! regulation of organelle organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051276 ! chromosome organization
relationship: regulates GO:0051276 ! chromosome organization

[Term]
id: GO:0033045
name: regulation of sister chromatid segregation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sister chromatid segregation." [GOC:mah]
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0033044 ! regulation of chromosome organization
is_a: GO:0051983 ! regulation of chromosome segregation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000819 ! sister chromatid segregation
relationship: regulates GO:0000819 ! sister chromatid segregation

[Term]
id: GO:0033046
name: negative regulation of sister chromatid segregation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation." [GOC:mah]
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0033045 ! regulation of sister chromatid segregation
is_a: GO:0051985 ! negative regulation of chromosome segregation
is_a: GO:2001251 ! negative regulation of chromosome organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000819 ! sister chromatid segregation
relationship: negatively_regulates GO:0000819 ! sister chromatid segregation

[Term]
id: GO:0033047
name: regulation of mitotic sister chromatid segregation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sister chromatid segregation during mitosis." [GOC:mah]
is_a: GO:0007088 ! regulation of mitotic nuclear division
is_a: GO:0033045 ! regulation of sister chromatid segregation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000070 ! mitotic sister chromatid segregation
relationship: regulates GO:0000070 ! mitotic sister chromatid segregation

[Term]
id: GO:0033048
name: negative regulation of mitotic sister chromatid segregation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation during mitosis." [GOC:mah]
is_a: GO:0033046 ! negative regulation of sister chromatid segregation
is_a: GO:0033047 ! regulation of mitotic sister chromatid segregation
is_a: GO:0045839 ! negative regulation of mitotic nuclear division
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000070 ! mitotic sister chromatid segregation
relationship: negatively_regulates GO:0000070 ! mitotic sister chromatid segregation

[Term]
id: GO:0033049
name: clavulanic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving clavulanic acid, (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid." [CHEBI:3736, GOC:mah]
synonym: "clavulanic acid metabolism" EXACT []
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0043603 ! cellular amide metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process

[Term]
id: GO:0033050
name: clavulanic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of clavulanic acid, (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid." [CHEBI:3736, GOC:mah]
synonym: "clavulanic acid anabolism" EXACT []
synonym: "clavulanic acid biosynthesis" EXACT []
synonym: "clavulanic acid formation" EXACT []
synonym: "clavulanic acid synthesis" EXACT []
xref: Wikipedia:Clavulanic_acid
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0033049 ! clavulanic acid metabolic process
is_a: GO:0043604 ! amide biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process

[Term]
id: GO:0033051
name: aminophosphonate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aminophosphonates, phosphonic acid derivatives that contain an amino group." [GOC:mah, http://pages.unibas.ch/mdpi/ecsoc/a0045/a0045.htm, KEGG:map00440]
synonym: "aminophosphonate metabolism" EXACT []
is_a: GO:0019634 ! organic phosphonate metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process

[Term]
id: GO:0033052
name: cyanoamino acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cyanoamino acids, amino acid derivatives that contain a cyanide group." [GOC:mah, PMID:11575729]
synonym: "cyanoamino acid metabolism" EXACT []
is_a: GO:0006520 ! cellular amino acid metabolic process
is_a: GO:0006575 ! cellular modified amino acid metabolic process
is_a: GO:0050898 ! nitrile metabolic process

[Term]
id: GO:0033053
name: D-glutamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-glutamine, the D-enantiomer of the amino acid glutamine, i.e. (2R)-2,5-diamino-5-oxopentanoic acid." [CHEBI:17061, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "D-glutamine metabolism" EXACT []
is_a: GO:0006541 ! glutamine metabolic process
is_a: GO:0046144 ! D-alanine family amino acid metabolic process
is_a: GO:0046416 ! D-amino acid metabolic process

[Term]
id: GO:0033054
name: D-glutamate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-glutamate, the D-enantiomer of the amino acid glutamate, i.e. (2R)-2-aminopentanedioic acid." [CHEBI:15966, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "D-glutamate metabolism" EXACT []
is_a: GO:0006536 ! glutamate metabolic process
is_a: GO:0046144 ! D-alanine family amino acid metabolic process
is_a: GO:0046416 ! D-amino acid metabolic process

[Term]
id: GO:0033055
name: D-arginine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-arginine, the D-enantiomer of the amino acid arginine, i.e. (2R)-2-amino-5-(carbamimidamido)pentanoic acid." [CHEBI:15816, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "D-arginine metabolism" EXACT []
is_a: GO:0006525 ! arginine metabolic process
is_a: GO:0046144 ! D-alanine family amino acid metabolic process
is_a: GO:0046416 ! D-amino acid metabolic process

[Term]
id: GO:0033056
name: D-ornithine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-ornithine, the D-enantiomer of the amino acid ornithine, i.e. (2R)-2,5-diaminopentanoic acid." [CHEBI:16176, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "D-ornithine metabolism" EXACT []
is_a: GO:0006591 ! ornithine metabolic process
is_a: GO:0046144 ! D-alanine family amino acid metabolic process
is_a: GO:0046416 ! D-amino acid metabolic process
is_a: GO:0097164 ! ammonium ion metabolic process

[Term]
id: GO:0033058
name: directional locomotion
namespace: biological_process
def: "Self-propelled movement of a cell or organism from one location to another along an axis." [GOC:mtg_MIT_16mar07]
is_a: GO:0040011 ! locomotion

[Term]
id: GO:0033059
name: cellular pigmentation
namespace: biological_process
def: "The deposition or aggregation of coloring matter in a cell." [GOC:mtg_MIT_16mar07]
subset: gosubset_prok
is_a: GO:0043473 ! pigmentation
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0033060
name: ocellus pigmentation
namespace: biological_process
def: "The deposition or aggregation of coloring matter in an ocellus, a minute simple eye found in many invertebrates." [GOC:mtg_MIT_16mar07]
is_a: GO:0043473 ! pigmentation

[Term]
id: GO:0033061
name: DNA recombinase mediator complex
namespace: cellular_component
def: "A protein complex containing accessory proteins which bind a recombinase (e.g. Rad51) and bind single-stranded DNA (ssDNA), and promote nucleation of the recombinase onto ssDNA." [GOC:elh, GOC:mah, GOC:vw, InterPro:IPR003488, PMID:12912992]
comment: Many paralogs of Rad51 act as recombinase mediators. These paralogs dimerize (or occasionally form tetramers) amongst themselves to form complexes with ssDNA-binding activity, and which act as mediators of Rad51 presynaptic filament assembly.
subset: goslim_pir
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0033062
name: Rhp55-Rhp57 complex
namespace: cellular_component
def: "A conserved heterodimeric DNA recombinase mediator complex that contains the RecA family proteins Rhp55p and Rph57 in Schizosaccharomyces, or orthologs thereof (e.g. Rad55p and Rad57p in Saccharomyces)." [GOC:mah, GOC:vw]
synonym: "Rad55-Rad57 complex" EXACT []
is_a: GO:0033061 ! DNA recombinase mediator complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0033063
name: Rad51B-Rad51C-Rad51D-XRCC2 complex
namespace: cellular_component
def: "A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51B, RAD51C, RAD51D, and XRCC2, or orthologs thereof." [GOC:mah, PMID:16093548, PMID:17114795]
synonym: "BCDX2 complex" EXACT []
is_a: GO:0033061 ! DNA recombinase mediator complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0033064
name: XRCC2-RAD51D complex
namespace: cellular_component
def: "A heterodimeric DNA recombinase mediator complex that contains the Rad51 paralogs RAD51D and XRCC2, or orthologs thereof; conserved from fission yeast to human but absent from budding yeast." [GOC:mah, GOC:vw, PMID:16093548]
synonym: "DX2 complex" EXACT []
is_a: GO:0033061 ! DNA recombinase mediator complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0033065
name: Rad51C-XRCC3 complex
namespace: cellular_component
def: "A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51C and XRCC3, or orthologs thereof." [GOC:mah, PMID:16093548, PMID:17114795]
synonym: "CX3 complex" EXACT []
is_a: GO:0033061 ! DNA recombinase mediator complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0033066
name: Rad51B-Rad51C complex
namespace: cellular_component
def: "A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51B and RAD51C, or orthologs thereof." [GOC:mah, PMID:16093548, PMID:17114795]
synonym: "BC complex" EXACT []
is_a: GO:0033061 ! DNA recombinase mediator complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0033067
name: macrolide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving macrolides, any of a large group of polyketide compounds that contain a large lactone ring with few or no double bonds and no nitrogen atoms, linked glycosidically to one or more sugar groups. The macrolides include the carbomycins, the erythromycins, oleandomycin, oligomycins, and the spiramycins, and act as antibiotics, mainly against Gram-positive bacteria." [ISBN:0198506732, PMID:17298179]
subset: gosubset_prok
synonym: "macrolide metabolism" EXACT []
is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0030638 ! polyketide metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:1901334 ! lactone metabolic process

[Term]
id: GO:0033068
name: macrolide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways leading to the formation of macrolides, any of a large group of polyketide compounds that contain a large lactone ring with few or no double bonds and no nitrogen atoms, linked glycosidically to one or more sugar groups. The macrolides include the carbomycins, the erythromycins, oleandomycin, oligomycins, and the spiramycins, and act as antibiotics, mainly against Gram-positive bacteria." [ISBN:0198506732, PMID:17298179]
subset: gosubset_prok
synonym: "macrolide anabolism" EXACT []
synonym: "macrolide biosynthesis" EXACT []
synonym: "macrolide formation" EXACT []
synonym: "macrolide synthesis" EXACT []
is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0030639 ! polyketide biosynthetic process
is_a: GO:0033067 ! macrolide metabolic process
is_a: GO:1901336 ! lactone biosynthetic process

[Term]
id: GO:0033069
name: ansamycin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ansamycins, any of a group of complex macrolactam compounds characterized by a cyclic structure in which an aliphatic ansa chain forms a bridge between two non-adjacent positions of a cyclic p-system; many exhibit antibacterial, antifungal or antitumor activity." [GOC:mah, http://ww2.icho.edu.pl/cednets/rydzyna/meyer.htm]
subset: gosubset_prok
synonym: "ansamycin metabolism" EXACT []
is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0030638 ! polyketide metabolic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0033070
name: ansamycin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways leading to the formation of ansamycins, any of a group of complex macrolactam compounds characterized by a cyclic structure in which an aliphatic ansa chain forms a bridge between two non-adjacent positions of a cyclic p-system; many exhibit antibacterial, antifungal or antitumor activity." [GOC:mah, http://ww2.icho.edu.pl/cednets/rydzyna/meyer.htm]
subset: gosubset_prok
synonym: "ansamycin anabolism" EXACT []
synonym: "ansamycin biosynthesis" EXACT []
synonym: "ansamycin formation" EXACT []
synonym: "ansamycin synthesis" EXACT []
is_a: GO:0030639 ! polyketide biosynthetic process
is_a: GO:0033069 ! ansamycin metabolic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process

[Term]
id: GO:0033071
name: vancomycin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving vancomycin, (3S,6R,7R,11R,23S,26S,30aS,36R,38aR)-44-[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyloxy]-3-(carbamoylmethyl)-10,19-dichloro-2,3,4,5,6,7,23,25,26,36,37,38,38a-tetradecahydro-7,22,28,30,32-pentahydroxy-6-(N-methyl-D-leucyl)-2,5,24,38,39-pentaoxo-1H,22H-23,36-(epiminomethano)-8,11:18,21-dietheno-13,16:31,35-di(metheno)[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine-26-carboxylic acid, a complex glycopeptide from Streptomyces orientalis that inhibits a specific step in the synthesis of the peptidoglycan layer in Gram-positive bacteria." [CHEBI:28001, GOC:mah]
subset: gosubset_prok
synonym: "vancomycin metabolism" EXACT []
is_a: GO:0030650 ! peptide antibiotic metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:0033072
name: vancomycin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways leading to the formation of vancomycin, (3S,6R,7R,11R,23S,26S,30aS,36R,38aR)-44-[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyloxy]-3-(carbamoylmethyl)-10,19-dichloro-2,3,4,5,6,7,23,25,26,36,37,38,38a-tetradecahydro-7,22,28,30,32-pentahydroxy-6-(N-methyl-D-leucyl)-2,5,24,38,39-pentaoxo-1H,22H-23,36-(epiminomethano)-8,11:18,21-dietheno-13,16:31,35-di(metheno)[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine-26-carboxylic acid, a complex glycopeptide from Streptomyces orientalis that inhibits a specific step in the synthesis of the peptidoglycan layer in Gram-positive bacteria." [CHEBI:28001, GOC:mah]
subset: gosubset_prok
synonym: "vancomycin anabolism" EXACT []
synonym: "vancomycin biosynthesis" EXACT []
synonym: "vancomycin formation" EXACT []
synonym: "vancomycin synthesis" EXACT []
is_a: GO:0019184 ! nonribosomal peptide biosynthetic process
is_a: GO:0030651 ! peptide antibiotic biosynthetic process
is_a: GO:0033071 ! vancomycin metabolic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process

[Term]
id: GO:0033073
name: pinene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the monoterpenoid pinene; alpha-pinene is (1S,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-2-ene, and beta-pinene is (1S,5S)-6,6-dimethyl-2-methylenebicyclo[3.1.1]heptane." [GOC:mah, http://www.chem.qmul.ac.uk/iubmb/enzyme/glossary/pinene.html]
subset: gosubset_prok
synonym: "pinene metabolism" EXACT []
is_a: GO:0043692 ! monoterpene metabolic process

[Term]
id: GO:0033074
name: pinene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways leading to the breakdown of the monoterpenoid pinene; alpha-pinene is (1S,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-2-ene, and beta-pinene is (1S,5S)-6,6-dimethyl-2-methylenebicyclo[3.1.1]heptane." [GOC:mah, http://www.chem.qmul.ac.uk/iubmb/enzyme/glossary/pinene.html]
synonym: "pinene breakdown" EXACT []
synonym: "pinene catabolism" EXACT []
synonym: "pinene degradation" EXACT []
is_a: GO:0033073 ! pinene metabolic process
is_a: GO:0043694 ! monoterpene catabolic process

[Term]
id: GO:0033075
name: isoquinoline alkaloid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of isoquinoline alkaloids, alkaloid compounds that contain bicyclic N-containing aromatic rings and are derived from a 3,4-dihydroxytyramine (dopamine) precursor that undergoes a Schiff base addition with aldehydes of different origin." [GOC:mah, http://www.life.uiuc.edu/ib/425/lecture32.html]
subset: gosubset_prok
synonym: "ipecac alkaloid biosynthesis" RELATED []
synonym: "isoquinoline alkaloid anabolism" EXACT []
synonym: "isoquinoline alkaloid biosynthesis" EXACT []
synonym: "isoquinoline alkaloid formation" EXACT []
synonym: "isoquinoline alkaloid synthesis" EXACT []
is_a: GO:0009821 ! alkaloid biosynthetic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0033076 ! isoquinoline alkaloid metabolic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process

[Term]
id: GO:0033076
name: isoquinoline alkaloid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving isoquinoline alkaloids, alkaloid compounds that contain bicyclic N-containing aromatic rings and are derived from a 3,4-dihydroxytyramine (dopamine) precursor that undergoes a Schiff base addition with aldehydes of different origin." [GOC:mah, http://www.life.uiuc.edu/ib/425/lecture32.html]
subset: gosubset_prok
synonym: "ipecac alkaloid metabolism" RELATED []
synonym: "isoquinoline alkaloid metabolism" EXACT []
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0009820 ! alkaloid metabolic process
is_a: GO:0034641 ! cellular nitrogen compound metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process

[Term]
id: GO:0033077
name: T cell differentiation in thymus
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway dependent upon transit through the thymus." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "T cell development in thymus" RELATED [GOC:add]
synonym: "thymic T cell differentiation" EXACT []
synonym: "thymocyte cell differentiation" EXACT []
synonym: "thymocyte differentiation" EXACT []
is_a: GO:0030217 ! T cell differentiation
is_a: GO:0071594 ! thymocyte aggregation

[Term]
id: GO:0033078
name: extrathymic T cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway independent of the thymus." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "extrathymic T cell development" RELATED [GOC:add]
is_a: GO:0030217 ! T cell differentiation

[Term]
id: GO:0033079
name: immature T cell proliferation
namespace: biological_process
def: "The expansion of an immature T cell population by cell division." [GOC:add, ISBN:0781735149]
is_a: GO:0042098 ! T cell proliferation

[Term]
id: GO:0033080
name: immature T cell proliferation in thymus
namespace: biological_process
def: "The expansion of an immature T cell population by cell division in the thymus." [GOC:add, ISBN:0781735149]
synonym: "thymic T cell proliferation" EXACT []
synonym: "thymocyte cell proliferation" EXACT []
synonym: "thymocyte proliferation" EXACT []
is_a: GO:0033079 ! immature T cell proliferation
is_a: GO:0071594 ! thymocyte aggregation
relationship: part_of GO:0033077 ! T cell differentiation in thymus

[Term]
id: GO:0033081
name: regulation of T cell differentiation in thymus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of T cell differentiation in the thymus." [GOC:add, GOC:mah]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "regulation of T cell development in thymus" RELATED [GOC:add]
synonym: "regulation of thymic T cell differentiation" EXACT []
synonym: "regulation of thymocyte cell differentiation" EXACT []
synonym: "regulation of thymocyte differentiation" EXACT []
is_a: GO:0045580 ! regulation of T cell differentiation
is_a: GO:2000398 ! regulation of thymocyte aggregation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0033077 ! T cell differentiation in thymus
relationship: regulates GO:0033077 ! T cell differentiation in thymus

[Term]
id: GO:0033082
name: regulation of extrathymic T cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of extrathymic T cell differentiation." [GOC:add, GOC:mah]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "regulation of extrathymic T cell development" RELATED [GOC:add]
is_a: GO:0045580 ! regulation of T cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0033078 ! extrathymic T cell differentiation
relationship: regulates GO:0033078 ! extrathymic T cell differentiation

[Term]
id: GO:0033083
name: regulation of immature T cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of immature T cell proliferation." [GOC:add, GOC:mah]
is_a: GO:0042129 ! regulation of T cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0033079 ! immature T cell proliferation
relationship: regulates GO:0033079 ! immature T cell proliferation

[Term]
id: GO:0033084
name: regulation of immature T cell proliferation in thymus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of immature T cell proliferation in the thymus." [GOC:add, GOC:mah]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "regulation of thymic T cell proliferation" EXACT []
synonym: "regulation of thymocyte cell proliferation" EXACT []
synonym: "regulation of thymocyte proliferation" EXACT []
is_a: GO:0033081 ! regulation of T cell differentiation in thymus
is_a: GO:0033083 ! regulation of immature T cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0033080 ! immature T cell proliferation in thymus
relationship: regulates GO:0033080 ! immature T cell proliferation in thymus

[Term]
id: GO:0033085
name: negative regulation of T cell differentiation in thymus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation in the thymus." [GOC:add, GOC:mah]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "negative regulation of T cell development in thymus" RELATED [GOC:add]
synonym: "negative regulation of thymic T cell differentiation" EXACT []
synonym: "negative regulation of thymocyte cell differentiation" EXACT []
synonym: "negative regulation of thymocyte differentiation" EXACT []
is_a: GO:0033081 ! regulation of T cell differentiation in thymus
is_a: GO:0045581 ! negative regulation of T cell differentiation
is_a: GO:2000399 ! negative regulation of thymocyte aggregation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0033077 ! T cell differentiation in thymus
relationship: negatively_regulates GO:0033077 ! T cell differentiation in thymus

[Term]
id: GO:0033086
name: negative regulation of extrathymic T cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of extrathymic T cell differentiation." [GOC:add, GOC:mah]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "negative regulation of extrathymic T cell development" RELATED [GOC:add]
is_a: GO:0033082 ! regulation of extrathymic T cell differentiation
is_a: GO:0045581 ! negative regulation of T cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0033078 ! extrathymic T cell differentiation
relationship: negatively_regulates GO:0033078 ! extrathymic T cell differentiation

[Term]
id: GO:0033087
name: negative regulation of immature T cell proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of immature T cell proliferation." [GOC:add, GOC:mah]
is_a: GO:0033083 ! regulation of immature T cell proliferation
is_a: GO:0042130 ! negative regulation of T cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0033079 ! immature T cell proliferation
relationship: negatively_regulates GO:0033079 ! immature T cell proliferation

[Term]
id: GO:0033088
name: negative regulation of immature T cell proliferation in thymus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of immature T cell proliferation in the thymus." [GOC:add, GOC:mah]
synonym: "negative regulation of thymic T cell proliferation" EXACT []
synonym: "negative regulation of thymocyte cell proliferation" EXACT []
synonym: "negative regulation of thymocyte proliferation" EXACT []
is_a: GO:0033084 ! regulation of immature T cell proliferation in thymus
is_a: GO:0033085 ! negative regulation of T cell differentiation in thymus
is_a: GO:0033087 ! negative regulation of immature T cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0033080 ! immature T cell proliferation in thymus
relationship: negatively_regulates GO:0033080 ! immature T cell proliferation in thymus

[Term]
id: GO:0033089
name: positive regulation of T cell differentiation in thymus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T cell differentiation in the thymus." [GOC:add, GOC:mah]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "positive regulation of T cell development in thymus" RELATED [GOC:add]
synonym: "positive regulation of thymic T cell differentiation" EXACT []
synonym: "positive regulation of thymocyte cell differentiation" EXACT []
synonym: "positive regulation of thymocyte differentiation" EXACT []
is_a: GO:0033081 ! regulation of T cell differentiation in thymus
is_a: GO:0045582 ! positive regulation of T cell differentiation
is_a: GO:2000400 ! positive regulation of thymocyte aggregation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0033077 ! T cell differentiation in thymus
relationship: positively_regulates GO:0033077 ! T cell differentiation in thymus

[Term]
id: GO:0033090
name: positive regulation of extrathymic T cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of extrathymic T cell differentiation." [GOC:add, GOC:mah]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "positive regulation of extrathymic T cell development" RELATED [GOC:add]
is_a: GO:0033082 ! regulation of extrathymic T cell differentiation
is_a: GO:0045582 ! positive regulation of T cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0033078 ! extrathymic T cell differentiation
relationship: positively_regulates GO:0033078 ! extrathymic T cell differentiation

[Term]
id: GO:0033091
name: positive regulation of immature T cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of immature T cell proliferation." [GOC:add, GOC:mah]
is_a: GO:0033083 ! regulation of immature T cell proliferation
is_a: GO:0042102 ! positive regulation of T cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0033079 ! immature T cell proliferation
relationship: positively_regulates GO:0033079 ! immature T cell proliferation

[Term]
id: GO:0033092
name: positive regulation of immature T cell proliferation in thymus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of immature T cell proliferation in the thymus." [GOC:add, GOC:mah]
synonym: "positive regulation of thymic T cell proliferation" EXACT []
synonym: "positive regulation of thymocyte cell proliferation" EXACT []
synonym: "positive regulation of thymocyte proliferation" EXACT []
is_a: GO:0033084 ! regulation of immature T cell proliferation in thymus
is_a: GO:0033089 ! positive regulation of T cell differentiation in thymus
is_a: GO:0033091 ! positive regulation of immature T cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0033080 ! immature T cell proliferation in thymus
relationship: positively_regulates GO:0033080 ! immature T cell proliferation in thymus

[Term]
id: GO:0033093
name: Weibel-Palade body
namespace: cellular_component
def: "A large, elongated, rod-shaped secretory granule characteristic of vascular endothelial cells that contain a number of structurally and functionally distinct proteins, of which the best characterized are von Willebrand factor (VWF) and P-selectin. Weibel-Palade bodies are formed from the trans-Golgi network in a process that depends on VWF, which is densely packed in a highly organized manner, and on coat proteins that remain associated with the granules. Upon cell stimulation, regulated exocytosis releases the contained proteins to the cell surface, where they act in the recruitment of platelets and leukocytes and in inflammatory and vasoactive responses." [PMID:11935287, PMID:16087708]
xref: Wikipedia:Weibel-Palade_body
is_a: GO:0030136 ! clathrin-coated vesicle
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0033094
name: butane-1,4-diamine:2-oxoglutarate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: putrescine + 2-oxoglutarate = L-glutamate + 1-pyrroline + H2O." [EC:2.6.1.82, GOC:mlg]
synonym: "PAT activity" RELATED []
synonym: "putrescine aminotransferase activity" BROAD [EC:2.6.1.82]
synonym: "putrescine transaminase activity" BROAD []
synonym: "putrescine-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.82]
synonym: "putrescine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.82]
synonym: "putrescine:alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.82]
synonym: "YgjG" RELATED [EC:2.6.1.82]
xref: EC:2.6.1.82
xref: MetaCyc:2.6.1.82-RXN
xref: RHEA:24655
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0033095
name: aleurone grain
namespace: cellular_component
def: "A membrane-bounded storage granule found in cells of the aleurone layer in plants; contains either a protein matrix, protein-carbohydrate bodies and/or globoids. Aleurone grains are formed by the vacuole, rough endoplasmic reticulum and dictyosomes." [http://ejournal.sinica.edu.tw/bbas/content/2004/1/bot451-08.pdf, http://www.springerlink.com/content/q7183h5vr7358278/]
synonym: "aleurone body" EXACT []
is_a: GO:0016023 ! cytoplasmic, membrane-bounded vesicle

[Term]
id: GO:0033096
name: amyloplast envelope
namespace: cellular_component
def: "The double lipid bilayer enclosing the amyloplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:mah]
is_a: GO:0009526 ! plastid envelope
relationship: part_of GO:0009501 ! amyloplast

[Term]
id: GO:0033097
name: amyloplast membrane
namespace: cellular_component
def: "Either of the lipid bilayers that surround an amyloplast and form the amyloplast envelope." [GOC:ecd]
is_a: GO:0042170 ! plastid membrane
relationship: part_of GO:0033096 ! amyloplast envelope

[Term]
id: GO:0033098
name: amyloplast inner membrane
namespace: cellular_component
def: "The inner, i.e. lumen-facing, lipid bilayer of the amyloplast envelope; also faces the amyloplast stroma." [GOC:ecd]
is_a: GO:0009528 ! plastid inner membrane
is_a: GO:0033097 ! amyloplast membrane

[Term]
id: GO:0033099
name: attachment organelle
namespace: cellular_component
def: "A membrane-bounded extension of the cell, originally characterized in Mycoplasma species, that contains an electron-dense core that is part of the cytoskeleton and is oriented lengthwise and ends distally in a bulbous knob (terminal button). Required for adherence to host cells and involved in gliding motility and cell division." [http://authors.library.caltech.edu/3529/, PMID:11325545, PMID:12003948]
subset: goslim_pir
is_a: GO:0043231 ! intracellular membrane-bounded organelle

[Term]
id: GO:0033100
name: NuA3 histone acetyltransferase complex
namespace: cellular_component
def: "A Gcn5-independent multisubunit complex that catalyzes the acetylation of histone H3. The budding yeast complex includes Sas3p, Taf30p, and Yng1p." [PMID:10817755, PMID:17157260]
is_a: GO:0070775 ! H3 histone acetyltransferase complex

[Term]
id: GO:0033101
name: cellular bud membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a cellular bud." [GOC:mah]
synonym: "cellular bud plasma membrane" EXACT []
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005933 ! cellular bud

[Term]
id: GO:0033102
name: acidocalcisome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding an acidocalcisome." [GOC:ecd, PMID:11378195]
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0098588 ! bounding membrane of organelle
is_a: GO:0098805 ! whole membrane
relationship: part_of GO:0020022 ! acidocalcisome

[Term]
id: GO:0033103
name: protein secretion by the type VI secretion system
namespace: biological_process
def: "The process in which proteins are transferred into the extracellular milieu or directly into host cells by the type VI secretion system. Proteins secreted by this system do not require an N-terminal signal sequence." [GOC:mlg, PMID:16432199, PMID:16763151]
comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular component term 'type VI protein secretion system complex ; GO:0033104'.
synonym: "protein secretion by the T6SS" EXACT []
synonym: "protein secretion by the type VI protein secretion system" EXACT []
synonym: "type VI protein secretion system" EXACT []
is_a: GO:0009306 ! protein secretion
is_a: GO:0071806 ! protein transmembrane transport

[Term]
id: GO:0033104
name: type VI protein secretion system complex
namespace: cellular_component
def: "A complex of proteins that permits the transfer of proteins into the extracellular milieu or directly into host cells via the type VI secretion system. Proteins secreted by this complex do not require an N-terminal signal sequence." [GOC:mlg, PMID:16432199, PMID:16763151]
subset: gosubset_prok
synonym: "T6SS complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0033105
name: chlorosome envelope
namespace: cellular_component
def: "The structure, composed of a monolayer of glycolipids with embedded proteins, that encloses the pigments and other contents of the chlorosome." [PMID:14507718, PMID:14729689, PMID:17303128]
comment: Note that the chlorosome envelope is not a single or double lipid bilayer, so this term is not a child of 'organelle membrane ; GO:0031090' or 'organelle envelope ; GO:0031967'.
synonym: "chlorosome membrane" EXACT []
is_a: GO:0034646 ! organelle-enclosing lipid monolayer
relationship: part_of GO:0046858 ! chlorosome

[Term]
id: GO:0033106
name: cis-Golgi network membrane
namespace: cellular_component
def: "The lipid bilayer surrounding any of the compartments that make up the cis-Golgi network." [GOC:mah]
synonym: "cis Golgi network membrane" EXACT []
synonym: "Golgi cis face membrane" RELATED []
is_a: GO:0044424 ! intracellular part
is_a: GO:0098588 ! bounding membrane of organelle
relationship: part_of GO:0005801 ! cis-Golgi network

[Term]
id: GO:0033107
name: CVT vesicle
namespace: cellular_component
def: "A cytosolic vesicle that is enclosed by a double membrane and is implicated in the cytoplasm to vacuole targeting pathway. These vesicles are found in the yeast S. cerevisiae, and contain vacuolar hydrolases, aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p)." [GOC:rb, PMID:15138258]
is_a: GO:0016023 ! cytoplasmic, membrane-bounded vesicle

[Term]
id: GO:0033108
name: mitochondrial respiratory chain complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a mitochondrial respiratory chain complex." [GOC:mah]
is_a: GO:0043623 ! cellular protein complex assembly
relationship: part_of GO:0007005 ! mitochondrion organization

[Term]
id: GO:0033110
name: Cvt vesicle membrane
namespace: cellular_component
def: "Either of the two lipid bilayers surrounding a Cvt vesicle, a vesicle that functions in the cytoplasm-to-vacuole targeting (Cvt) pathway." [GOC:ecd, PMID:20065092]
is_a: GO:0030659 ! cytoplasmic vesicle membrane
relationship: part_of GO:0033107 ! CVT vesicle

[Term]
id: GO:0033111
name: attachment organelle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding an attachment organelle.  This is a region of the cell membrane facing the environment - in mycoplasma, part of the mycolate outer membrane." [GOC:ecd]
is_a: GO:0044424 ! intracellular part
is_a: GO:0098588 ! bounding membrane of organelle
is_a: GO:0098589 ! membrane region
relationship: part_of GO:0033099 ! attachment organelle

[Term]
id: GO:0033112
name: cyanelle envelope
namespace: cellular_component
def: "The double lipid bilayer enclosing the cyanelle and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:mah]
is_a: GO:0009526 ! plastid envelope
relationship: part_of GO:0009842 ! cyanelle

[Term]
id: GO:0033113
name: cyanelle membrane
namespace: cellular_component
def: "Either of the lipid bilayers that surround a cyanelle and form the cyanelle envelope." [GOC:ecd]
is_a: GO:0042170 ! plastid membrane
relationship: part_of GO:0033112 ! cyanelle envelope

[Term]
id: GO:0033114
name: cyanelle thylakoid lumen
namespace: cellular_component
def: "The volume enclosed by a cyanelle thylakoid membrane." [GOC:mah]
is_a: GO:0031978 ! plastid thylakoid lumen
relationship: part_of GO:0009843 ! cyanelle thylakoid

[Term]
id: GO:0033115
name: cyanelle thylakoid membrane
namespace: cellular_component
def: "The lipid bilayer membrane of any thylakoid within a cyanelle." [GOC:mah]
is_a: GO:0055035 ! plastid thylakoid membrane
relationship: part_of GO:0009843 ! cyanelle thylakoid

[Term]
id: GO:0033116
name: endoplasmic reticulum-Golgi intermediate compartment membrane
namespace: cellular_component
def: "The lipid bilayer surrounding any of the compartments of the endoplasmic reticulum (ER)-Golgi intermediate compartment system." [GOC:mah, GOC:pr, PMID:16723730]
synonym: "ER-Golgi intermediate compartment membrane" EXACT []
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0098588 ! bounding membrane of organelle
relationship: part_of GO:0005793 ! endoplasmic reticulum-Golgi intermediate compartment

[Term]
id: GO:0033117
name: esterosome
namespace: cellular_component
def: "A vesicle filled with crystalline protein that shows sequence similarities with various esterases." [GOC:ecd, PMID:2307702]
is_a: GO:0016023 ! cytoplasmic, membrane-bounded vesicle

[Term]
id: GO:0033118
name: esterosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding an esterosome. This membrane has characteristics of rough endoplasmic reticulum (RER) membranes." [GOC:ecd, PMID:2307702]
is_a: GO:0030659 ! cytoplasmic vesicle membrane
is_a: GO:0098588 ! bounding membrane of organelle
is_a: GO:0098805 ! whole membrane
relationship: part_of GO:0033117 ! esterosome

[Term]
id: GO:0033119
name: negative regulation of RNA splicing
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of RNA splicing." [GOC:mah]
is_a: GO:0010629 ! negative regulation of gene expression
is_a: GO:0043484 ! regulation of RNA splicing
is_a: GO:0051253 ! negative regulation of RNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008380 ! RNA splicing
relationship: negatively_regulates GO:0008380 ! RNA splicing

[Term]
id: GO:0033120
name: positive regulation of RNA splicing
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of RNA splicing." [GOC:mah]
is_a: GO:0010628 ! positive regulation of gene expression
is_a: GO:0043484 ! regulation of RNA splicing
is_a: GO:0051254 ! positive regulation of RNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008380 ! RNA splicing
relationship: positively_regulates GO:0008380 ! RNA splicing

[Term]
id: GO:0033121
name: regulation of purine nucleotide catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides." [GOC:mah]
synonym: "regulation of purine nucleotide breakdown" EXACT []
synonym: "regulation of purine nucleotide catabolism" EXACT []
synonym: "regulation of purine nucleotide degradation" EXACT []
is_a: GO:0030811 ! regulation of nucleotide catabolic process
is_a: GO:1900542 ! regulation of purine nucleotide metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006195 ! purine nucleotide catabolic process
relationship: regulates GO:0006195 ! purine nucleotide catabolic process

[Term]
id: GO:0033122
name: negative regulation of purine nucleotide catabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides." [GOC:mah]
synonym: "negative regulation of purine nucleotide breakdown" EXACT []
synonym: "negative regulation of purine nucleotide catabolism" EXACT []
synonym: "negative regulation of purine nucleotide degradation" EXACT []
is_a: GO:0030812 ! negative regulation of nucleotide catabolic process
is_a: GO:0033121 ! regulation of purine nucleotide catabolic process
is_a: GO:1900543 ! negative regulation of purine nucleotide metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006195 ! purine nucleotide catabolic process
relationship: negatively_regulates GO:0006195 ! purine nucleotide catabolic process

[Term]
id: GO:0033123
name: positive regulation of purine nucleotide catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides." [GOC:mah]
synonym: "positive regulation of purine nucleotide breakdown" EXACT []
synonym: "positive regulation of purine nucleotide catabolism" EXACT []
synonym: "positive regulation of purine nucleotide degradation" EXACT []
is_a: GO:0030813 ! positive regulation of nucleotide catabolic process
is_a: GO:0033121 ! regulation of purine nucleotide catabolic process
is_a: GO:1900544 ! positive regulation of purine nucleotide metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006195 ! purine nucleotide catabolic process
relationship: positively_regulates GO:0006195 ! purine nucleotide catabolic process

[Term]
id: GO:0033124
name: obsolete regulation of GTP catabolic process
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [GOC:mah]
comment: The reason for making this term obsolete is that it gets misused in cases where phosphates are simply being removed from a small molecule. We found no cases where these molecules genuinely underwent catabolism.
synonym: "regulation of GTP breakdown" EXACT []
synonym: "regulation of GTP catabolism" EXACT []
synonym: "regulation of GTP degradation" EXACT []
is_obsolete: true
consider: GO:0043087

[Term]
id: GO:0033125
name: obsolete negative regulation of GTP catabolic process
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [GOC:mah]
comment: The reason for making this term obsolete is that it gets misused in cases where phosphates are simply being removed from a small molecule. We found no cases where these molecules genuinely underwent catabolism.
synonym: "negative regulation of GTP breakdown" EXACT []
synonym: "negative regulation of GTP catabolism" EXACT []
synonym: "negative regulation of GTP degradation" EXACT []
is_obsolete: true
consider: GO:0034260

[Term]
id: GO:0033126
name: obsolete positive regulation of GTP catabolic process
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [GOC:mah]
comment: The reason for making this term obsolete is that it gets misused in cases where phosphates are simply being removed from a small molecule. We found no cases where these molecules genuinely underwent catabolism.
synonym: "positive regulation of GTP breakdown" EXACT []
synonym: "positive regulation of GTP catabolism" EXACT []
synonym: "positive regulation of GTP degradation" EXACT []
is_obsolete: true
consider: GO:0043547

[Term]
id: GO:0033127
name: regulation of histone phosphorylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the addition of one or more phosphate groups to a histone protein." [GOC:mah]
is_a: GO:0001932 ! regulation of protein phosphorylation
is_a: GO:0031056 ! regulation of histone modification
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016572 ! histone phosphorylation
relationship: regulates GO:0016572 ! histone phosphorylation

[Term]
id: GO:0033128
name: negative regulation of histone phosphorylation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of one or more phosphate groups to a histone protein." [GOC:mah]
is_a: GO:0001933 ! negative regulation of protein phosphorylation
is_a: GO:0031057 ! negative regulation of histone modification
is_a: GO:0033127 ! regulation of histone phosphorylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016572 ! histone phosphorylation
relationship: negatively_regulates GO:0016572 ! histone phosphorylation

[Term]
id: GO:0033129
name: positive regulation of histone phosphorylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the addition of one or more phosphate groups to a histone protein." [GOC:mah]
is_a: GO:0001934 ! positive regulation of protein phosphorylation
is_a: GO:0031058 ! positive regulation of histone modification
is_a: GO:0033127 ! regulation of histone phosphorylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016572 ! histone phosphorylation
relationship: positively_regulates GO:0016572 ! histone phosphorylation

[Term]
id: GO:0033130
name: acetylcholine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an acetylcholine receptor." [GOC:mah]
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0033131
name: regulation of glucokinase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glucokinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a glucose molecule." [GOC:mah]
synonym: "glucokinase regulator" NARROW []
is_a: GO:0010906 ! regulation of glucose metabolic process
is_a: GO:1903299 ! regulation of hexokinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004340 ! glucokinase activity
relationship: regulates GO:0004340 ! glucokinase activity

[Term]
id: GO:0033132
name: negative regulation of glucokinase activity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of glucokinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a glucose molecule." [GOC:mah]
synonym: "down regulation of glucokinase activity" EXACT []
synonym: "down-regulation of glucokinase activity" EXACT []
synonym: "downregulation of glucokinase activity" EXACT []
synonym: "glucokinase inhibitor" NARROW []
synonym: "inhibition of glucokinase activity" NARROW []
is_a: GO:0033131 ! regulation of glucokinase activity
is_a: GO:1903300 ! negative regulation of hexokinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004340 ! glucokinase activity
relationship: negatively_regulates GO:0004340 ! glucokinase activity

[Term]
id: GO:0033133
name: positive regulation of glucokinase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glucokinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a glucose molecule." [GOC:mah]
synonym: "glucokinase activator" NARROW []
synonym: "stimulation of glucokinase activity" NARROW []
synonym: "up regulation of glucokinase activity" EXACT []
synonym: "up-regulation of glucokinase activity" EXACT []
synonym: "upregulation of glucokinase activity" EXACT []
is_a: GO:0033131 ! regulation of glucokinase activity
is_a: GO:1903301 ! positive regulation of hexokinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004340 ! glucokinase activity
relationship: positively_regulates GO:0004340 ! glucokinase activity

[Term]
id: GO:0033134
name: ubiquitin activating enzyme binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a ubiquitin activating enzyme, any of the E1 proteins." [GOC:mah]
is_a: GO:0044388 ! small protein activating enzyme binding

[Term]
id: GO:0033135
name: regulation of peptidyl-serine phosphorylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-serine." [GOC:mah]
subset: gosubset_prok
is_a: GO:0001932 ! regulation of protein phosphorylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0018105 ! peptidyl-serine phosphorylation
relationship: regulates GO:0018105 ! peptidyl-serine phosphorylation

[Term]
id: GO:0033136
name: serine phosphorylation of STAT3 protein
namespace: biological_process
def: "The process of introducing a phosphate group to a serine residue of the STAT3 protein." [GOC:jl, GOC:mah]
is_a: GO:0042501 ! serine phosphorylation of STAT protein

[Term]
id: GO:0033137
name: negative regulation of peptidyl-serine phosphorylation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-serine." [GOC:mah]
is_a: GO:0001933 ! negative regulation of protein phosphorylation
is_a: GO:0033135 ! regulation of peptidyl-serine phosphorylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0018105 ! peptidyl-serine phosphorylation
relationship: negatively_regulates GO:0018105 ! peptidyl-serine phosphorylation

[Term]
id: GO:0033138
name: positive regulation of peptidyl-serine phosphorylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine." [GOC:mah]
is_a: GO:0001934 ! positive regulation of protein phosphorylation
is_a: GO:0033135 ! regulation of peptidyl-serine phosphorylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0018105 ! peptidyl-serine phosphorylation
relationship: positively_regulates GO:0018105 ! peptidyl-serine phosphorylation

[Term]
id: GO:0033139
name: regulation of peptidyl-serine phosphorylation of STAT protein
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:mah]
is_a: GO:0033135 ! regulation of peptidyl-serine phosphorylation
is_a: GO:0046425 ! regulation of JAK-STAT cascade
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042501 ! serine phosphorylation of STAT protein
relationship: regulates GO:0042501 ! serine phosphorylation of STAT protein

[Term]
id: GO:0033140
name: negative regulation of peptidyl-serine phosphorylation of STAT protein
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:mah]
is_a: GO:0033137 ! negative regulation of peptidyl-serine phosphorylation
is_a: GO:0033139 ! regulation of peptidyl-serine phosphorylation of STAT protein
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042501 ! serine phosphorylation of STAT protein
relationship: negatively_regulates GO:0042501 ! serine phosphorylation of STAT protein

[Term]
id: GO:0033141
name: positive regulation of peptidyl-serine phosphorylation of STAT protein
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:mah]
is_a: GO:0033138 ! positive regulation of peptidyl-serine phosphorylation
is_a: GO:0033139 ! regulation of peptidyl-serine phosphorylation of STAT protein
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042501 ! serine phosphorylation of STAT protein
relationship: positively_regulates GO:0042501 ! serine phosphorylation of STAT protein

[Term]
id: GO:0033142
name: progesterone receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a progesterone receptor." [GOC:mah]
is_a: GO:0035258 ! steroid hormone receptor binding

[Term]
id: GO:0033143
name: regulation of intracellular steroid hormone receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway." [GOC:mah]
synonym: "regulation of steroid hormone receptor signaling pathway" BROAD [GOC:bf]
synonym: "regulation of steroid hormone receptor signalling pathway" BROAD []
is_a: GO:0009966 ! regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030518 ! intracellular steroid hormone receptor signaling pathway
relationship: regulates GO:0030518 ! intracellular steroid hormone receptor signaling pathway

[Term]
id: GO:0033144
name: negative regulation of intracellular steroid hormone receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway." [GOC:mah]
synonym: "negative regulation of steroid hormone receptor signaling pathway" BROAD [GOC:bf]
synonym: "negative regulation of steroid hormone receptor signalling pathway" BROAD [GOC:bf]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0033143 ! regulation of intracellular steroid hormone receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030518 ! intracellular steroid hormone receptor signaling pathway
relationship: negatively_regulates GO:0030518 ! intracellular steroid hormone receptor signaling pathway

[Term]
id: GO:0033145
name: positive regulation of intracellular steroid hormone receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway." [GOC:mah]
synonym: "positive regulation of steroid hormone receptor signaling pathway" BROAD [GOC:bf]
synonym: "positive regulation of steroid hormone receptor signalling pathway" BROAD []
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0033143 ! regulation of intracellular steroid hormone receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030518 ! intracellular steroid hormone receptor signaling pathway
relationship: positively_regulates GO:0030518 ! intracellular steroid hormone receptor signaling pathway

[Term]
id: GO:0033146
name: regulation of intracellular estrogen receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway." [GOC:mah]
synonym: "regulation of estrogen receptor signaling pathway" BROAD [GOC:bf]
synonym: "regulation of estrogen receptor signalling pathway" EXACT []
is_a: GO:0033143 ! regulation of intracellular steroid hormone receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030520 ! intracellular estrogen receptor signaling pathway
relationship: regulates GO:0030520 ! intracellular estrogen receptor signaling pathway

[Term]
id: GO:0033147
name: negative regulation of intracellular estrogen receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway." [GOC:mah]
synonym: "negative regulation of estrogen receptor signaling pathway" BROAD [GOC:bf]
synonym: "negative regulation of estrogen receptor signalling pathway" EXACT []
is_a: GO:0033144 ! negative regulation of intracellular steroid hormone receptor signaling pathway
is_a: GO:0033146 ! regulation of intracellular estrogen receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030520 ! intracellular estrogen receptor signaling pathway
relationship: negatively_regulates GO:0030520 ! intracellular estrogen receptor signaling pathway

[Term]
id: GO:0033148
name: positive regulation of intracellular estrogen receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway." [GOC:mah]
synonym: "positive regulation of estrogen receptor signaling pathway" BROAD [GOC:bf]
synonym: "positive regulation of estrogen receptor signalling pathway" BROAD []
is_a: GO:0033145 ! positive regulation of intracellular steroid hormone receptor signaling pathway
is_a: GO:0033146 ! regulation of intracellular estrogen receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030520 ! intracellular estrogen receptor signaling pathway
relationship: positively_regulates GO:0030520 ! intracellular estrogen receptor signaling pathway

[Term]
id: GO:0033149
name: FFAT motif binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the FFAT motif, a short motif containing diphenylalanine in an acidic tract that targets proteins to the cytosolic surface of the ER and to the nuclear membrane by binding directly to members of the VAP (VAMP-associated protein) protein family." [PMID:12727870, PMID:15455074, PMID:16004875]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0033150
name: cytoskeletal calyx
namespace: cellular_component
def: "A large cytoskeletal structure located at the posterior end of the perinuclear theca of a mammalian sperm head. The nucleus is tightly associated with the calyx, which contains calicin and basic cylicin proteins." [PMID:12243744, PMID:9184090]
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0033011 ! perinuclear theca

[Term]
id: GO:0033151
name: V(D)J recombination
namespace: biological_process
def: "The process in which immune receptor V, D, and J, or V and J gene segments, depending on the specific receptor, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS)." [GOC:add, ISBN:0781700221, ISBN:0781735149]
synonym: "V(D)J joining" EXACT []
synonym: "V-D-J joining" EXACT []
synonym: "V-D-J recombination" EXACT []
synonym: "V-J joining" EXACT []
synonym: "V-J recombination" EXACT []
xref: Wikipedia:V(D)J_recombination
is_a: GO:0002562 ! somatic diversification of immune receptors via germline recombination within a single locus

[Term]
id: GO:0033152
name: immunoglobulin V(D)J recombination
namespace: biological_process
def: "The process in which immunoglobulin gene segments are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS). For immunoglobulin heavy chains V, D, and J gene segments are joined, and for immunoglobulin light chains V and J gene segments are joined." [GOC:add, ISBN:0781735149]
synonym: "immunoglobulin V(D)J joining" EXACT [GOC:add]
synonym: "immunoglobulin V-D-J joining" NARROW [GOC:add]
synonym: "immunoglobulin V-D-J recombination" NARROW [GOC:add]
synonym: "immunoglobulin V-J joining" NARROW [GOC:add]
synonym: "immunoglobulin V-J recombination" NARROW [GOC:add]
is_a: GO:0016447 ! somatic recombination of immunoglobulin gene segments
is_a: GO:0033151 ! V(D)J recombination

[Term]
id: GO:0033153
name: T cell receptor V(D)J recombination
namespace: biological_process
def: "The process in which T cell receptor V, D, and J, or V and J gene segments, depending on the specific locus, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS)." [GOC:add, ISBN:0781700221]
synonym: "T cell receptor V(D)J joining" EXACT [GOC:add]
synonym: "T cell receptor V-D-J joining" NARROW [GOC:add]
synonym: "T cell receptor V-D-J recombination" NARROW [GOC:add]
synonym: "T cell receptor V-J joining" NARROW [GOC:add]
synonym: "T cell receptor V-J recombination" NARROW [GOC:add]
synonym: "T-cell receptor V(D)J recombination" EXACT [GOC:add]
synonym: "TCR V(D)J recombination" EXACT [GOC:add]
is_a: GO:0002681 ! somatic recombination of T cell receptor gene segments
is_a: GO:0033151 ! V(D)J recombination

[Term]
id: GO:0033154
name: oligogalacturonide transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + oligogalacturonide(out) = ADP + phosphate + oligogalacturonide(in)." [GOC:mlg]
is_a: GO:0015422 ! oligosaccharide-transporting ATPase activity
is_a: GO:0015478 ! oligosaccharide transporting porin activity
is_a: GO:0033155 ! oligogalacturonide transmembrane transporter activity

[Term]
id: GO:0033155
name: oligogalacturonide transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of oligogalacturonide from one side of the membrane to the other." [GOC:mlg]
is_a: GO:0015157 ! oligosaccharide transmembrane transporter activity
relationship: part_of GO:0033156 ! oligogalacturonide transport

[Term]
id: GO:0033156
name: oligogalacturonide transport
namespace: biological_process
def: "The directed movement of oligogalacturonides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mlg]
is_a: GO:0015772 ! oligosaccharide transport

[Term]
id: GO:0033157
name: regulation of intracellular protein transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells." [GOC:mah]
is_a: GO:0032386 ! regulation of intracellular transport
is_a: GO:0051223 ! regulation of protein transport
is_a: GO:1903827 ! regulation of cellular protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006886 ! intracellular protein transport
relationship: regulates GO:0006886 ! intracellular protein transport

[Term]
id: GO:0033158
name: regulation of protein import into nucleus, translocation
namespace: biological_process
def: "Any process that modulates the vectorial transfer of a protein from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:mah]
synonym: "regulation of protein import into cell nucleus, translocation" EXACT []
is_a: GO:0042306 ! regulation of protein import into nucleus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000060 ! protein import into nucleus, translocation
relationship: regulates GO:0000060 ! protein import into nucleus, translocation

[Term]
id: GO:0033159
name: negative regulation of protein import into nucleus, translocation
namespace: biological_process
def: "Any process that stops, prevents or reduces the vectorial transfer of a protein from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:mah]
synonym: "negative regulation of protein import into cell nucleus, translocation" EXACT []
is_a: GO:0033158 ! regulation of protein import into nucleus, translocation
is_a: GO:0042308 ! negative regulation of protein import into nucleus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000060 ! protein import into nucleus, translocation
relationship: negatively_regulates GO:0000060 ! protein import into nucleus, translocation

[Term]
id: GO:0033160
name: positive regulation of protein import into nucleus, translocation
namespace: biological_process
def: "Any process that activates or increases the vectorial transfer of a protein from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:mah]
synonym: "positive regulation of protein import into cell nucleus, translocation" EXACT []
is_a: GO:0033158 ! regulation of protein import into nucleus, translocation
is_a: GO:0042307 ! positive regulation of protein import into nucleus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000060 ! protein import into nucleus, translocation
relationship: positively_regulates GO:0000060 ! protein import into nucleus, translocation

[Term]
id: GO:0033161
name: mitogen-activated protein kinase kinase kinase kinase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase kinase kinase, any protein that can phosphorylate a MAP kinase kinase kinase." [GOC:mah]
synonym: "MAPKKKK binding" EXACT []
is_a: GO:0019901 ! protein kinase binding

[Term]
id: GO:0033162
name: melanosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a melanosome." [GOC:mah]
is_a: GO:0030659 ! cytoplasmic vesicle membrane
is_a: GO:0098588 ! bounding membrane of organelle
is_a: GO:0098805 ! whole membrane
relationship: part_of GO:0042470 ! melanosome
relationship: part_of GO:0045009 ! chitosome

[Term]
id: GO:0033163
name: microneme membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a microneme." [GOC:mah]
is_a: GO:0044424 ! intracellular part
is_a: GO:0098588 ! bounding membrane of organelle
relationship: part_of GO:0020009 ! microneme

[Term]
id: GO:0033164
name: glycolipid 6-alpha-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->6)-D-mannosyl-D-mannose linkage." [EC:2.4.1.232, GOC:mcc, PMID:16878994]
synonym: "GDP-mannose:glycolipid 1,6-alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.232]
synonym: "GDP-mannose:oligosaccharide 1,6-alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.232]
synonym: "GDP-mannose:oligosaccharide 6-alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.232]
synonym: "initiation-specific alpha-1,6-mannosyltransferase activity" EXACT [EC:2.4.1.232]
xref: EC:2.4.1.232
xref: MetaCyc:2.4.1.232-RXN
is_a: GO:0000009 ! alpha-1,6-mannosyltransferase activity
is_a: GO:0004376 ! glycolipid mannosyltransferase activity

[Term]
id: GO:0033165
name: interphotoreceptor matrix
namespace: cellular_component
def: "A specialized extracellularc matrix that surrounds the photoreceptors of the retina and lies between them and the apical surface of the retinal pigment epithelium. The IPM has been implicated in several important activities required for photoreceptor function and maintenance." [http://www.glycoforum.gr.jp/science/hyaluronan/HA17/HA17E.html, PMID:1862095, PMID:2194288]
is_a: GO:0005578 ! proteinaceous extracellular matrix

[Term]
id: GO:0033166
name: hyaline layer
namespace: cellular_component
def: "A multilayered extraembryonic matrix that functions as a substrate for cell adhesion through early development. It is thought to protect and lubricate the embryo, stabilize the blastomeres during morphogenesis, and regulate nutrient intake. The major constituent of the hyaline layer is the protein hyalin. This matrix has been found in echinoderms." [http://worms.zoology.wisc.edu/urchins/SUgast_ECM3.html, PMID:1721506, PMID:9473317]
is_a: GO:0005578 ! proteinaceous extracellular matrix

[Term]
id: GO:0033167
name: ARC complex
namespace: cellular_component
def: "A ribonucleoprotein complex that contains members of the Argonaute family of proteins, additional protein subunits, and duplex siRNA; required for heterochromatin assembly and siRNA generation. Possibly involved in the conversion of ds siRNA to ss siRNA." [GOC:vw, PMID:17310250]
synonym: "argonaute siRNA chaperone complex" EXACT []
is_a: GO:0031332 ! RNAi effector complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0033168
name: conversion of ds siRNA to ss siRNA involved in RNA interference
namespace: biological_process
def: "The process in which double-stranded siRNA molecules are converted to single-stranded siRNAs; required for the formation of a mature RITS complex during RNA interference." [GOC:mah, PMID:17310250]
synonym: "RNA interference, conversion of ds siRNA to ss siRNA" EXACT [GOC:mah]
is_a: GO:0036404 ! conversion of ds siRNA to ss siRNA
intersection_of: GO:0036404 ! conversion of ds siRNA to ss siRNA
intersection_of: part_of GO:0016246 ! RNA interference
relationship: part_of GO:0016246 ! RNA interference
relationship: part_of GO:0030422 ! production of siRNA involved in RNA interference

[Term]
id: GO:0033169
name: histone H3-K9 demethylation
namespace: biological_process
def: "The modification of histone H3 by the removal of a methyl group from lysine at position 9 of the histone." [GOC:mah]
is_a: GO:0070076 ! histone lysine demethylation

[Term]
id: GO:0033170
name: protein-DNA loading ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the assembly of a protein or protein complex onto a DNA molecule." [GOC:mah, GOC:vw]
synonym: "DNA-protein loading ATPase activity" EXACT [GOC:mah]
is_a: GO:0008094 ! DNA-dependent ATPase activity

[Term]
id: GO:0033171
name: obsolete nucleoprotein filament-forming ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the assembly of proteins such as Rad51p onto single-stranded (ss) DNA to form a helical nucleoprotein filament." [GOC:mah, GOC:vw]
comment: This term was made obsolete because nucleoprotein filament formation does not require ATP hydrolysis, so the term is misleading.
synonym: "nucleoprotein filament-forming ATPase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0033172
name: gas vesicle shell
namespace: cellular_component
def: "The proteinaceous structure surrounding a gas vesicle." [GOC:ecd]
synonym: "gas vesicle membrane" RELATED []
synonym: "gas vesicle wall" EXACT []
is_a: GO:0044446 ! intracellular organelle part
relationship: part_of GO:0031411 ! gas vesicle

[Term]
id: GO:0033173
name: calcineurin-NFAT signaling cascade
namespace: biological_process
def: "Any intracellular signal transduction in which the signal is passed on within the by activation of a member of the NFAT protein family as a consequence of NFAT dephosphorylation by Ca(2+)-activated calcineurin. The cascade begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin dephosphorylates multiple phosphoserine residues on NFAT, resulting in the translocation of NFAT to the nucleus. The cascade ends with regulation of transcription by NFAT. The calcineurin-NFAT cascade lies downstream of many cell surface receptors, including G-protein coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs) that signal to mobilize calcium ions (Ca2+)." [GOC:lm, GOC:mah, PMID:12975316, PMID:15928679]
synonym: "calcineurin-NFAT signaling pathway" RELATED [GOC:bf]
synonym: "calcineurin-NFAT signalling pathway" RELATED []
is_a: GO:0019722 ! calcium-mediated signaling
is_a: GO:0048016 ! inositol phosphate-mediated signaling

[Term]
id: GO:0033174
name: chloroplast proton-transporting ATP synthase complex, catalytic core CF(1)
namespace: cellular_component
def: "The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the chloroplast thylakoid membrane when the entire ATP synthase is assembled. The chloroplast F0 domain contains three alpha, three beta, one gamma, one delta, and one epsilon subunits." [GOC:mah, GOC:pj, PMID:11032839]
synonym: "chloroplast proton-transporting F-type ATPase complex, catalytic core CF(1)" EXACT []
is_a: GO:0045261 ! proton-transporting ATP synthase complex, catalytic core F(1)
is_a: GO:0098807 ! chloroplast thylakoid membrane protein complex
relationship: part_of GO:0045320 ! chloroplast proton-transporting ATP synthase complex

[Term]
id: GO:0033175
name: chloroplast proton-transporting ATP synthase complex, coupling factor CF(o)
namespace: cellular_component
def: "All non-F1 subunits of the chloroplast hydrogen-transporting ATP synthase, including integral and peripheral chloroplast thylakoid membrane proteins." [GOC:mah]
synonym: "chloroplast proton-transporting ATP synthase complex, coupling factor CF(0)" EXACT []
synonym: "chloroplast proton-transporting F-type ATPase complex, coupling factor CF(o)" EXACT []
is_a: GO:0045263 ! proton-transporting ATP synthase complex, coupling factor F(o)
is_a: GO:0098807 ! chloroplast thylakoid membrane protein complex
relationship: part_of GO:0045320 ! chloroplast proton-transporting ATP synthase complex

[Term]
id: GO:0033176
name: proton-transporting V-type ATPase complex
namespace: cellular_component
def: "A proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient. The resulting transmembrane electrochemical potential of H+ is used to drive a variety of (i) secondary active transport systems via H+-dependent symporters and antiporters and (ii) channel-mediated transport systems. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis. V-type ATPases are found in the membranes of organelles such as vacuoles, endosomes, and lysosomes, and in the plasma membrane." [GOC:mah, ISBN:0716743663, PMID:16449553]
synonym: "hydrogen-translocating V-type ATPase complex" EXACT []
is_a: GO:0016469 ! proton-transporting two-sector ATPase complex

[Term]
id: GO:0033177
name: proton-transporting two-sector ATPase complex, proton-transporting domain
namespace: cellular_component
def: "A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins." [GOC:mah, PMID:10838056]
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0016469 ! proton-transporting two-sector ATPase complex

[Term]
id: GO:0033178
name: proton-transporting two-sector ATPase complex, catalytic domain
namespace: cellular_component
def: "A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled." [GOC:mah, PMID:10838056]
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0016469 ! proton-transporting two-sector ATPase complex

[Term]
id: GO:0033179
name: proton-transporting V-type ATPase, V0 domain
namespace: cellular_component
def: "A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring." [GOC:mah, ISBN:0716743663, PMID:16449553]
is_a: GO:0033177 ! proton-transporting two-sector ATPase complex, proton-transporting domain
relationship: part_of GO:0033176 ! proton-transporting V-type ATPase complex

[Term]
id: GO:0033180
name: proton-transporting V-type ATPase, V1 domain
namespace: cellular_component
def: "A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A." [GOC:mah, ISBN:0716743663, PMID:16449553]
is_a: GO:0033178 ! proton-transporting two-sector ATPase complex, catalytic domain
relationship: part_of GO:0033176 ! proton-transporting V-type ATPase complex

[Term]
id: GO:0033181
name: plasma membrane proton-transporting V-type ATPase complex
namespace: cellular_component
def: "A proton-transporting two-sector ATPase complex found in the plasma membrane." [GOC:mah]
synonym: "plasma membrane hydrogen ion-transporting ATPase" EXACT []
is_a: GO:0033176 ! proton-transporting V-type ATPase complex
is_a: GO:0098797 ! plasma membrane protein complex
intersection_of: GO:0033176 ! proton-transporting V-type ATPase complex
intersection_of: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0005886 ! plasma membrane

[Term]
id: GO:0033182
name: regulation of histone ubiquitination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the addition of a ubiquitin group to a histone protein." [GOC:mah]
is_a: GO:0031056 ! regulation of histone modification
is_a: GO:0031396 ! regulation of protein ubiquitination
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016574 ! histone ubiquitination
relationship: regulates GO:0016574 ! histone ubiquitination

[Term]
id: GO:0033183
name: negative regulation of histone ubiquitination
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of a ubiquitin group to a histone protein." [GOC:mah]
is_a: GO:0031057 ! negative regulation of histone modification
is_a: GO:0031397 ! negative regulation of protein ubiquitination
is_a: GO:0033182 ! regulation of histone ubiquitination
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016574 ! histone ubiquitination
relationship: negatively_regulates GO:0016574 ! histone ubiquitination

[Term]
id: GO:0033184
name: positive regulation of histone ubiquitination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the addition of a ubiquitin group to a histone protein." [GOC:mah]
is_a: GO:0031058 ! positive regulation of histone modification
is_a: GO:0031398 ! positive regulation of protein ubiquitination
is_a: GO:0033182 ! regulation of histone ubiquitination
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016574 ! histone ubiquitination
relationship: positively_regulates GO:0016574 ! histone ubiquitination

[Term]
id: GO:0033185
name: dolichol-phosphate-mannose synthase complex
namespace: cellular_component
def: "A protein complex that possesses dolichyl-phosphate beta-D-mannosyltransferase activity; contains a catalytic subunit, a regulatory subunit, and a third subunit that stabilizes the complex. In human and several other metazoa, the subunits are named DPM1, DPM2 and DPM3, respectively." [PMID:10835346]
synonym: "dolichyl-phosphate beta-D-mannosyltransferase complex" EXACT []
synonym: "DPM synthase complex" EXACT []
is_a: GO:0031501 ! mannosyltransferase complex

[Term]
id: GO:0033186
name: CAF-1 complex
namespace: cellular_component
def: "A conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). In many species the CAF-1 subunits are designated p150, p60, and p48." [PMID:17065558, PMID:17083276]
comment: In yeast the subunits are MSI1/p50, CAC2/p60 and CAC1/p90.
synonym: "chromatin assembly factor 1 complex" EXACT []
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0033187
name: obsolete inositol hexakisphosphate 4-kinase or 6-kinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate, and ATP + 1D-myo-inositol hexakisphosphate = ADP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate." [PMID:17412958, PMID:17412959]
comment: This term was made obsolete because it represents two reactions, and should be two separate terms.
synonym: "inositol hexakisphosphate 4-kinase or 6-kinase activity" EXACT []
is_obsolete: true
consider: GO:0000830
consider: GO:0000831

[Term]
id: GO:0033188
name: sphingomyelin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-diacyl-sn-glycero-3-phosphocholine + ceramide = 1,2-diacyl-sn-glycerol + sphingomyelin." [EC:2.7.8.27, RHEA:18768]
synonym: "ceramide:phosphatidylcholine cholinephosphotransferase activity" EXACT [EC:2.7.8.27]
synonym: "phosphatidylcholine:ceramide cholinephosphotransferase activity" EXACT [EC:2.7.8.27]
synonym: "SM synthase activity" EXACT [EC:2.7.8.27]
synonym: "SMS1" RELATED [EC:2.7.8.27]
synonym: "SMS2" RELATED [EC:2.7.8.27]
xref: EC:2.7.8.27
xref: KEGG:R08969
xref: MetaCyc:2.7.8.27-RXN
xref: Reactome:REACT_106693 "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1], Mus musculus"
xref: Reactome:REACT_107598 "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2], Gallus gallus"
xref: Reactome:REACT_19278 "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2], Homo sapiens"
xref: Reactome:REACT_19414 "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1], Homo sapiens"
xref: Reactome:REACT_29413 "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1], Bos taurus"
xref: Reactome:REACT_30104 "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2], Canis familiaris"
xref: Reactome:REACT_31066 "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1], Gallus gallus"
xref: Reactome:REACT_34573 "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2], Xenopus tropicalis"
xref: Reactome:REACT_78545 "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1], Xenopus tropicalis"
xref: Reactome:REACT_80864 "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2], Bos taurus"
xref: Reactome:REACT_81369 "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1], Taeniopygia guttata"
xref: Reactome:REACT_82419 "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1], Canis familiaris"
xref: Reactome:REACT_83588 "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2], Taeniopygia guttata"
xref: Reactome:REACT_84761 "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2], Mus musculus"
xref: Reactome:REACT_88038 "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1], Sus scrofa"
xref: Reactome:REACT_93330 "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2], Danio rerio"
xref: Reactome:REACT_93661 "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1], Danio rerio"
xref: Reactome:REACT_95128 "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2], Sus scrofa"
xref: Reactome:REACT_98008 "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2], Rattus norvegicus"
xref: Reactome:REACT_98575 "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1], Rattus norvegicus"
xref: RHEA:18768
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0033189
name: response to vitamin A
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin A stimulus." [GOC:sl]
synonym: "response to retinol" NARROW []
is_a: GO:0033273 ! response to vitamin
is_a: GO:0033993 ! response to lipid

[Term]
id: GO:0033190
name: solanapyrone synthase activity
namespace: molecular_function
def: "Catalysis of the cyclization of double bonds in prosolanapyrone II to form (-)-solanapyrone A." [GOC:cb, PMID:9659400]
is_a: GO:0009975 ! cyclase activity

[Term]
id: GO:0033191
name: macrophomate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 2-pyrone + oxalacetate = macrophomate." [CHEBI:38228, GOC:cb, PMID:10984474]
is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups

[Term]
id: GO:0033192
name: calmodulin-dependent protein phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate, dependent on the presence of calcium-bound calmodulin." [GOC:mah, PMID:15359118]
synonym: "Ca2+/CaM-dependent protein phosphatase activity" RELATED []
synonym: "calcineurin activity" NARROW []
synonym: "calcium- and calmodulin-dependent protein phosphatase activity" EXACT []
synonym: "calcium/calmodulin-dependent protein phosphatase activity" EXACT []
is_a: GO:0004723 ! calcium-dependent protein serine/threonine phosphatase activity

[Term]
id: GO:0033193
name: Lsd1/2 complex
namespace: cellular_component
def: "A nucleosome-binding protein complex that comprises two SWIRM domain histone demethylases and two PHD finger proteins. The complex is involved in transcriptional regulation via heterochromatic silencing and the regulation of chromatin boundary formation, and was first identified in fission yeast." [GOC:vw, PMID:17371846, PMID:17434129, PMID:17440621]
synonym: "SAPHIRE complex" EXACT [PMID:17371846]
synonym: "Swm complex" EXACT [PMID:17440621]
synonym: "Swm1/2 complex" RELATED [PMID:17440621]
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part

[Term]
id: GO:0033194
name: response to hydroperoxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH." [CHEBI:35923, GOC:mah]
subset: gosubset_prok
is_a: GO:0006979 ! response to oxidative stress
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0033195
name: response to alkyl hydroperoxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkyl hydroperoxide stimulus. Alkyl hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH, where the substituent is an alkyl group." [CHEBI:35923, GOC:mah]
is_a: GO:0010033 ! response to organic substance
is_a: GO:0033194 ! response to hydroperoxide

[Term]
id: GO:0033196
name: tryparedoxin peroxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: tryparedoxin + hydrogen peroxide = tryparedoxin disulfide + H2O." [GOC:mah]
synonym: "TXNPx activity" EXACT []
xref: MetaCyc:1.11.1.15-RXN
is_a: GO:0004601 ! peroxidase activity
is_a: GO:0051920 ! peroxiredoxin activity

[Term]
id: GO:0033197
name: response to vitamin E
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin E stimulus." [GOC:sl]
synonym: "response to DL-alpha-tocopherol acetate" NARROW []
synonym: "response to DL-alpha-tocopheryl acetate" NARROW []
synonym: "response to O-Acetyl-alpha-tocopherol" NARROW []
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033273 ! response to vitamin
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0033198
name: response to ATP
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus." [GOC:sl]
synonym: "response to adenosine 5'-triphosphate" EXACT []
synonym: "response to adenosine triphosphate" EXACT []
is_a: GO:0014074 ! response to purine-containing compound
is_a: GO:0046683 ! response to organophosphorus
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0033199
name: obsolete inositol heptakisphosphate 4-kinase or 6-kinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 4,5-bisdiphosphoinositol-1D-myoinositol (1,2,3,6)tetrakisphosphate, and ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 5,6-bisdiphosphoinositol-1D-myoinositol (1,2,3,4)tetrakisphosphate." [PMID:17412958]
comment: This term was made obsolete because it represents two reactions, and should be two separate terms.
synonym: "inositol heptakisphosphate 4-kinase or 6-kinase activity" EXACT []
is_obsolete: true
consider: GO:0000833
consider: GO:0000834

[Term]
id: GO:0033200
name: inositol heptakisphosphate 5-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate = 4,5-bisdiphosphoinositol-1D-myoinositol (1,2,3,6)tetrakisphosphate, and ATP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate = 5,6-bisdiphosphoinositol-1D-myoinositol (1,2,3,4)tetrakisphosphate." [PMID:17412958]
synonym: "diphosphoinositol-pentakisphosphate 5-kinase activity" EXACT []
synonym: "IP7 5-kinase activity" EXACT []
is_a: GO:0000829 ! inositol heptakisphosphate kinase activity

[Term]
id: GO:0033201
name: alpha-1,4-glucan synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: RDP-glucose + [alpha-D-glucosyl-(1,4)]n = RDP + [alpha-D-glucosyl-(1,4)]n+1, where RDP is ADP or UDP." [PMID:17472966]
synonym: "1,4-alpha-glucan synthase activity" EXACT []
xref: EC:2.4.1.21
xref: RHEA:18192
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0033202
name: DNA helicase complex
namespace: cellular_component
def: "A protein complex that possesses DNA helicase activity." [GOC:mah]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0044424 ! intracellular part
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0033203
name: DNA helicase A complex
namespace: cellular_component
def: "A homohexameric protein complex that possesses DNA helicase activity; associates with DNA polymerase alpha-primase and translocates in the 5' to 3' direction." [PMID:9341218]
is_a: GO:0033202 ! DNA helicase complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0033204
name: ribonuclease P RNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the RNA subunit of ribonuclease P." [GOC:pg, PMID:11455963]
synonym: "RNase P RNA binding" EXACT []
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0033206
name: meiotic cytokinesis
namespace: biological_process
def: "A cell cycle process that results in the division of the cytoplasm of a cell after meiosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]
synonym: "cytokinesis after meiosis" EXACT []
is_a: GO:0061640 ! cytoskeleton-dependent cytokinesis
is_a: GO:1903046 ! meiotic cell cycle process
intersection_of: GO:0061640 ! cytoskeleton-dependent cytokinesis
intersection_of: part_of GO:0051321 ! meiotic cell cycle
relationship: part_of GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0033207
name: beta-1,4-N-acetylgalactosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an acceptor molecule, forming a beta-1,4 linkage." [GOC:mah]
synonym: "beta-1,4-GalNAc transferase activity" EXACT []
is_a: GO:0008376 ! acetylgalactosaminyltransferase activity

[Term]
id: GO:0033208
name: UDP-N-acetylgalactosamine:N-acetylneuraminyl-alpha-2,3-galactosyl-beta-R 1,4-N-acetylgalactosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetylgalactosamine + N-acetylneuraminyl-alpha-2,3-galactosyl-beta-oligosaccharide = UDP + N-acetylgalactosaminyl-N-acetylneuraminyl-alpha-2,3-galactosyl-beta-oligosaccharide." [GOC:mah, PMID:12678917, PMID:16024623]
synonym: "Sda beta 1,4GalNAc transferase" RELATED []
synonym: "UDP-GalNAc:Neu5Ac-alpha-2-Gal-beta-1-R beta-1,4-N-acetylgalactosaminyltransferase activity" EXACT []
is_a: GO:0033207 ! beta-1,4-N-acetylgalactosaminyltransferase activity

[Term]
id: GO:0033209
name: tumor necrosis factor-mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling]
synonym: "adipocytokine signaling pathway" RELATED []
synonym: "TNF-alpha-mediated signaling pathway" NARROW []
synonym: "tumor necrosis factor alpha-mediated signaling pathway" NARROW []
synonym: "tumor necrosis factor-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0019221 ! cytokine-mediated signaling pathway
relationship: part_of GO:0071356 ! cellular response to tumor necrosis factor

[Term]
id: GO:0033210
name: leptin-mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of leptin to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body." [GOC:mah, GOC:signaling, GOC:yaf]
synonym: "adipocytokine signaling pathway" RELATED []
synonym: "leptin-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0019221 ! cytokine-mediated signaling pathway
relationship: part_of GO:0044320 ! cellular response to leptin stimulus

[Term]
id: GO:0033211
name: adiponectin-activated signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of adiponectin to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:20536390]
synonym: "adipocytokine signaling pathway" RELATED []
synonym: "adiponectin-mediated signaling pathway" RELATED []
synonym: "adiponectin-mediated signalling pathway" EXACT []
is_a: GO:0009755 ! hormone-mediated signaling pathway
is_a: GO:0019221 ! cytokine-mediated signaling pathway

[Term]
id: GO:0033212
name: iron assimilation
namespace: biological_process
def: "A process in which iron is solubilized and transported into a cell." [GOC:cjm, GOC:mah]
is_a: GO:0006879 ! cellular iron ion homeostasis
relationship: has_part GO:0097459 ! iron ion import into cell

[Term]
id: GO:0033213
name: iron assimilation by capture and transport
namespace: biological_process
def: "A process in which iron (Fe3+) is solubilized by binding to a receptor or transport protein and transported into a cell." [GOC:mah]
is_a: GO:0033212 ! iron assimilation
relationship: has_part GO:0034755 ! iron ion transmembrane transport

[Term]
id: GO:0033214
name: iron assimilation by chelation and transport
namespace: biological_process
def: "A process in which iron (Fe3+) is solubilized by ferric iron-specific chelators, known as siderophores, excreted by a cell; the iron-siderophore complex is then transported into the cell by specific cell surface receptors." [GOC:mah, PMID:16963626]
is_a: GO:0033212 ! iron assimilation
relationship: has_part GO:0098711 ! iron ion import across plasma membrane

[Term]
id: GO:0033215
name: iron assimilation by reduction and transport
namespace: biological_process
def: "A process in which iron is solubilized by reduction from Fe3+ to Fe2+ via a cell surface reductase and subsequent transport of the iron across the membrane by iron uptake proteins." [GOC:cjm, GOC:mah, PMID:16963626]
is_a: GO:0033212 ! iron assimilation
relationship: has_part GO:0000293 ! ferric-chelate reductase activity
relationship: has_part GO:0034755 ! iron ion transmembrane transport

[Term]
id: GO:0033216
name: ferric iron import
namespace: biological_process
def: "The directed movement of ferric iron (Fe(III) or Fe3+) ions into a cell or organelle." [GOC:mah]
synonym: "ferric ion import" EXACT []
synonym: "ferric iron uptake" EXACT []
is_a: GO:0015682 ! ferric iron transport
is_a: GO:0097286 ! iron ion import

[Term]
id: GO:0033217
name: regulation of transcription from RNA polymerase II promoter in response to iron ion starvation
namespace: biological_process
def: "Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of iron ions." [GOC:mah]
synonym: "regulation of transcription from RNA polymerase II promoter in response to iron deficiency" EXACT []
is_a: GO:0010106 ! cellular response to iron ion starvation
is_a: GO:0043618 ! regulation of transcription from RNA polymerase II promoter in response to stress

[Term]
id: GO:0033218
name: amide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [CHEBI:32988, GOC:mah]
subset: goslim_pir
is_a: GO:0005488 ! binding

[Term]
id: GO:0033219
name: urea binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with urea, a water-soluble carboxamide with the structure H2N-CO-NH2." [CHEBI:16199, GOC:mah, ISBN:0198506732]
is_a: GO:0033218 ! amide binding
is_a: GO:0036094 ! small molecule binding

[Term]
id: GO:0033220
name: amide-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O + amide(out) = ADP + phosphate + amide(in)." [GOC:mah]
subset: gosubset_prok
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances
is_a: GO:0042887 ! amide transmembrane transporter activity

[Term]
id: GO:0033221
name: urea-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O + urea(out) = ADP + phosphate + urea(in)." [GOC:mlg]
subset: gosubset_prok
synonym: "carbamide-transporting ATPase activity" EXACT []
xref: RHEA:32806
is_a: GO:0015204 ! urea transmembrane transporter activity
is_a: GO:0033220 ! amide-transporting ATPase activity

[Term]
id: GO:0033222
name: xylose binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the D- or L-enantiomer of xylose." [CHEBI:18222, GOC:mah]
subset: gosubset_prok
is_a: GO:0048029 ! monosaccharide binding

[Term]
id: GO:0033223
name: 2-aminoethylphosphonate transport
namespace: biological_process
def: "The directed movement of 2-aminoethylphosphonate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mlg]
synonym: "2-phosphonoethylamine transport" EXACT []
synonym: "ciliatine transport" EXACT []
is_a: GO:0044765 ! single-organism transport
is_a: GO:0071702 ! organic substance transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0033224
name: 2-aminoethylphosphonate transmembrane transporter activity
namespace: molecular_function
def: "Enables the directed movement of 2-aminoethylphosphonate into, out of or within a cell, or between cells." [GOC:mlg]
synonym: "2-phosphonoethylamine transmembrane transporter activity" EXACT []
synonym: "ciliatine transporter activity" EXACT []
is_a: GO:0022804 ! active transmembrane transporter activity
relationship: part_of GO:0033223 ! 2-aminoethylphosphonate transport

[Term]
id: GO:0033225
name: 2-aminoethylphosphonate transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O + 2-aminoethylphosphonate(out) = ADP + phosphate + 2-aminoethylphosphonate(in)." [GOC:mlg]
synonym: "2-phosphonoethylamine transporting ATPase activity" EXACT []
synonym: "ciliatine transportingATPase activity" EXACT []
xref: RHEA:32778
is_a: GO:0033224 ! 2-aminoethylphosphonate transmembrane transporter activity
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances

[Term]
id: GO:0033226
name: 2-aminoethylphosphonate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with 2-aminoethylphosphonate." [GOC:mlg]
synonym: "2-phosphonoethylamine binding" EXACT []
synonym: "ciliatine binding" EXACT []
is_a: GO:0005488 ! binding

[Term]
id: GO:0033227
name: dsRNA transport
namespace: biological_process
def: "The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
is_a: GO:0044765 ! single-organism transport
is_a: GO:0050658 ! RNA transport

[Term]
id: GO:0033228
name: cysteine export
namespace: biological_process
def: "The directed movement of cysteine out of a cell or organelle." [GOC:mlg]
is_a: GO:0032973 ! amino acid export
is_a: GO:0042883 ! cysteine transport

[Term]
id: GO:0033229
name: cysteine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of cysteine from one side of the membrane to the other." [GOC:mah]
is_a: GO:0000099 ! sulfur amino acid transmembrane transporter activity
is_a: GO:0008324 ! cation transmembrane transporter activity
is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity
relationship: part_of GO:1903712 ! cysteine transmembrane transport

[Term]
id: GO:0033230
name: cysteine-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cysteine(out/in) = ADP + phosphate + cysteine(in/out)." [GOC:mlg]
xref: RHEA:32798
is_a: GO:0015424 ! amino acid-transporting ATPase activity
is_a: GO:0019829 ! cation-transporting ATPase activity
is_a: GO:0033229 ! cysteine transmembrane transporter activity

[Term]
id: GO:0033231
name: carbohydrate export
namespace: biological_process
def: "The directed movement of carbohydrates out of a cell or organelle." [GOC:mlg]
is_a: GO:0008643 ! carbohydrate transport

[Term]
id: GO:0033232
name: D-methionine-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-methionine(out/in) = ADP + phosphate + D-methionine(in/out)." [GOC:mlg]
is_a: GO:0015424 ! amino acid-transporting ATPase activity
is_a: GO:0048474 ! D-methionine transmembrane transporter activity
is_a: GO:1901243 ! methionine transmembrane-transporting ATPase activity

[Term]
id: GO:0033233
name: regulation of protein sumoylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the addition of SUMO groups to a protein." [GOC:mah]
synonym: "regulation of sumoylation" EXACT []
is_a: GO:1903320 ! regulation of protein modification by small protein conjugation or removal
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016925 ! protein sumoylation
relationship: regulates GO:0016925 ! protein sumoylation

[Term]
id: GO:0033234
name: negative regulation of protein sumoylation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of SUMO groups to a protein." [GOC:mah]
synonym: "negative regulation of sumoylation" EXACT []
is_a: GO:0033233 ! regulation of protein sumoylation
is_a: GO:1903321 ! negative regulation of protein modification by small protein conjugation or removal
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016925 ! protein sumoylation
relationship: negatively_regulates GO:0016925 ! protein sumoylation

[Term]
id: GO:0033235
name: positive regulation of protein sumoylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the addition of SUMO groups to a protein." [GOC:mah]
synonym: "positive regulation of sumoylation" EXACT []
is_a: GO:0033233 ! regulation of protein sumoylation
is_a: GO:1903322 ! positive regulation of protein modification by small protein conjugation or removal
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016925 ! protein sumoylation
relationship: positively_regulates GO:0016925 ! protein sumoylation

[Term]
id: GO:0033236
name: obsolete 11-beta-hydroxysteroid dehydrogenase (NAD+) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+." [PMID:15761036]
synonym: "11-beta-hydroxysteroid dehydrogenase (NAD+) activity" EXACT []
is_obsolete: true
replaced_by: GO:0070523

[Term]
id: GO:0033237
name: obsolete 11-beta-hydroxysteroid dehydrogenase (NADP+) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: an 11-beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+." [EC:1.1.1.146]
synonym: "11-beta-hydroxysteroid dehydrogenase (NADP+) activity" EXACT []
synonym: "11beta-hydroxysteroid:NADP+ 11-oxidoreductase" EXACT [EC:1.1.1.146]
synonym: "beta-hydroxysteroid dehydrogenase" BROAD [EC:1.1.1.146]
synonym: "corticosteroid 11-beta-dehydrogenase activity" EXACT [EC:1.1.1.146]
xref: EC:1.1.1.146
xref: MetaCyc:11-BETA-HYDROXYSTEROID-DEHYDROGENASE-RXN
is_obsolete: true
replaced_by: GO:0070524

[Term]
id: GO:0033238
name: regulation of cellular amine metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform amines." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of amine metabolism" EXACT []
is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044106 ! cellular amine metabolic process
relationship: regulates GO:0044106 ! cellular amine metabolic process

[Term]
id: GO:0033239
name: negative regulation of cellular amine metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amines." [GOC:mah]
synonym: "negative regulation of amine metabolism" EXACT []
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0033238 ! regulation of cellular amine metabolic process
is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044106 ! cellular amine metabolic process
relationship: negatively_regulates GO:0044106 ! cellular amine metabolic process

[Term]
id: GO:0033240
name: positive regulation of cellular amine metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amines." [GOC:mah]
synonym: "positive regulation of amine metabolism" EXACT []
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0033238 ! regulation of cellular amine metabolic process
is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044106 ! cellular amine metabolic process
relationship: positively_regulates GO:0044106 ! cellular amine metabolic process

[Term]
id: GO:0033241
name: regulation of cellular amine catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines." [GOC:mah]
synonym: "regulation of amine breakdown" EXACT []
synonym: "regulation of amine catabolism" EXACT []
synonym: "regulation of amine degradation" EXACT []
is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:0033238 ! regulation of cellular amine metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009310 ! amine catabolic process
relationship: regulates GO:0009310 ! amine catabolic process

[Term]
id: GO:0033242
name: negative regulation of cellular amine catabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines." [GOC:mah]
synonym: "negative regulation of amine breakdown" EXACT []
synonym: "negative regulation of amine catabolism" EXACT []
synonym: "negative regulation of amine degradation" EXACT []
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:0033239 ! negative regulation of cellular amine metabolic process
is_a: GO:0033241 ! regulation of cellular amine catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009310 ! amine catabolic process
relationship: negatively_regulates GO:0009310 ! amine catabolic process

[Term]
id: GO:0033243
name: positive regulation of cellular amine catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines." [GOC:mah]
synonym: "positive regulation of amine breakdown" EXACT []
synonym: "positive regulation of amine catabolism" EXACT []
synonym: "positive regulation of amine degradation" EXACT []
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:0033240 ! positive regulation of cellular amine metabolic process
is_a: GO:0033241 ! regulation of cellular amine catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009310 ! amine catabolic process
relationship: positively_regulates GO:0009310 ! amine catabolic process

[Term]
id: GO:0033244
name: regulation of penicillin metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:mah]
synonym: "regulation of penicillin metabolism" EXACT []
is_a: GO:0010565 ! regulation of cellular ketone metabolic process
is_a: GO:0033238 ! regulation of cellular amine metabolic process
is_a: GO:0034248 ! regulation of cellular amide metabolic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
is_a: GO:0043455 ! regulation of secondary metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042316 ! penicillin metabolic process
relationship: regulates GO:0042316 ! penicillin metabolic process

[Term]
id: GO:0033245
name: negative regulation of penicillin metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:mah]
synonym: "negative regulation of penicillin metabolism" EXACT []
is_a: GO:0033239 ! negative regulation of cellular amine metabolic process
is_a: GO:0033244 ! regulation of penicillin metabolic process
is_a: GO:0034249 ! negative regulation of cellular amide metabolic process
is_a: GO:0051175 ! negative regulation of sulfur metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042316 ! penicillin metabolic process
relationship: negatively_regulates GO:0042316 ! penicillin metabolic process

[Term]
id: GO:0033246
name: positive regulation of penicillin metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:mah]
synonym: "positive regulation of penicillin metabolism" EXACT []
is_a: GO:0033240 ! positive regulation of cellular amine metabolic process
is_a: GO:0033244 ! regulation of penicillin metabolic process
is_a: GO:0034250 ! positive regulation of cellular amide metabolic process
is_a: GO:0051176 ! positive regulation of sulfur metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042316 ! penicillin metabolic process
relationship: positively_regulates GO:0042316 ! penicillin metabolic process

[Term]
id: GO:0033247
name: regulation of penicillin catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:mah]
synonym: "regulation of penicillin breakdown" EXACT []
synonym: "regulation of penicillin catabolism" EXACT []
synonym: "regulation of penicillin degradation" EXACT []
is_a: GO:0033244 ! regulation of penicillin metabolic process
is_a: GO:0034251 ! regulation of cellular amide catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042317 ! penicillin catabolic process
relationship: regulates GO:0042317 ! penicillin catabolic process

[Term]
id: GO:0033248
name: negative regulation of penicillin catabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:mah]
synonym: "negative regulation of penicillin breakdown" EXACT []
synonym: "negative regulation of penicillin catabolism" EXACT []
synonym: "negative regulation of penicillin degradation" EXACT []
is_a: GO:0033245 ! negative regulation of penicillin metabolic process
is_a: GO:0033247 ! regulation of penicillin catabolic process
is_a: GO:0034252 ! negative regulation of cellular amide catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042317 ! penicillin catabolic process
relationship: negatively_regulates GO:0042317 ! penicillin catabolic process

[Term]
id: GO:0033249
name: positive regulation of penicillin catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:mah]
synonym: "positive regulation of penicillin breakdown" EXACT []
synonym: "positive regulation of penicillin catabolism" EXACT []
synonym: "positive regulation of penicillin degradation" EXACT []
is_a: GO:0033246 ! positive regulation of penicillin metabolic process
is_a: GO:0033247 ! regulation of penicillin catabolic process
is_a: GO:0034253 ! positive regulation of cellular amide catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042317 ! penicillin catabolic process
relationship: positively_regulates GO:0042317 ! penicillin catabolic process

[Term]
id: GO:0033250
name: penicillinase activity
namespace: molecular_function
def: "Catalysis of the reaction: a penicillin + H2O = a substituted beta-amino acid derivative of the penicillin." [GOC:mlg]
xref: MetaCyc:BETA-LACTAMASE-RXN
is_a: GO:0008800 ! beta-lactamase activity

[Term]
id: GO:0033251
name: cephalosporinase activity
namespace: molecular_function
def: "Catalysis of the reaction: a cephalosporin + H2O = a substituted beta-amino acid derivative of the cephalosporin." [GOC:mlg]
xref: MetaCyc:BETA-LACTAMASE-RXN
is_a: GO:0008800 ! beta-lactamase activity

[Term]
id: GO:0033252
name: regulation of beta-lactamase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of beta-lactamase activity, the hydrolysis of a beta-lactam to yield a substituted beta-amino acid." [GOC:mah]
is_a: GO:0051336 ! regulation of hydrolase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008800 ! beta-lactamase activity
relationship: regulates GO:0008800 ! beta-lactamase activity

[Term]
id: GO:0033253
name: regulation of penicillinase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nuclease activity, the hydrolysis of a penicillin to yield a substituted beta-amino acid derivative." [GOC:mah]
is_a: GO:0033252 ! regulation of beta-lactamase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0033250 ! penicillinase activity
relationship: regulates GO:0033250 ! penicillinase activity

[Term]
id: GO:0033254
name: vacuolar transporter chaperone complex
namespace: cellular_component
def: "A protein complex that contains four related proteins that have been implicated in several membrane-related processes, such as sorting of H+-translocating ATPases, endocytosis, ER-Golgi trafficking, vacuole fusion, vacuolar polyphosphate homeostasis and the microautophagic scission of vesicles into the vacuolar lumen. The complex is enriched at the vacuolar membrane, but also found in other cellular compartments, including the ER and the cell periphery. In Saccharomyces, the subunits are Vtc1p, Vtc2p, Vtc3p and Vtc4p." [PMID:11823419, PMID:17079729]
synonym: "VTC complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0033255
name: SAS acetyltransferase complex
namespace: cellular_component
def: "A protein complex that possesses histone acetyltransferase activity and links histone acetylation to the assembly of transcriptionally silent chromatin. In vitro, the complex acetylates lysine 16 of histone H4 and lysine 14 of histone H3, although the latter may not be relevant in vivo. The complex contains a catalytic subunit and at least two other subunits; in Saccharomyces, the catalytic subunit is Sas2p and additional subunits are Sas4p and Sas5p." [PMID:11731480, PMID:12626510, PMID:15788653]
synonym: "SAS-I complex" EXACT []
is_a: GO:0032777 ! Piccolo NuA4 histone acetyltransferase complex

[Term]
id: GO:0033256
name: I-kappaB/NF-kappaB complex
namespace: cellular_component
def: "A protein complex containing an inhibitory-kappaB (I-kappaB/IKB) protein and one or more copies of an NF-kappaB protein. In the resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm." [GOC:bf, GOC:mah, PMID:9407099]
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0033257
name: Bcl3/NF-kappaB2 complex
namespace: cellular_component
def: "A protein complex containing one Bcl protein and one or more copies of NF-kappaB2; formation of complexes of different stoichiometry depends on the Bcl3:NF-kappaB2 ratio, and allow Bcl3 to exert different regulatory effects on NF-kappaB2-dependent transcription." [GOC:mah, PMID:9407099]
synonym: "Bcl3-NFKB2 complex" RELATED []
synonym: "Bcl3-p52 complex" EXACT []
is_a: GO:0033256 ! I-kappaB/NF-kappaB complex

[Term]
id: GO:0033258
name: plastid DNA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving plastid DNA." [GOC:mah]
synonym: "plastid DNA metabolism" EXACT []
is_a: GO:0006259 ! DNA metabolic process
relationship: part_of GO:0009657 ! plastid organization

[Term]
id: GO:0033259
name: plastid DNA replication
namespace: biological_process
def: "The process in which new strands of DNA are synthesized in a plastid." [GOC:mah]
synonym: "plastid DNA synthesis" RELATED []
synonym: "replication of plastid DNA" EXACT []
is_a: GO:0006261 ! DNA-dependent DNA replication
is_a: GO:0033258 ! plastid DNA metabolic process
intersection_of: GO:0006261 ! DNA-dependent DNA replication
intersection_of: occurs_in GO:0009536 ! plastid
relationship: occurs_in GO:0009536 ! plastid

[Term]
id: GO:0033260
name: nuclear DNA replication
namespace: biological_process
def: "The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle." [GOC:mtg_cell_cycle]
synonym: "DNA replication during S phase" RELATED [GOC:dph, GOC:tb]
synonym: "DNA replication involved in S phase" EXACT []
synonym: "DNA replication involved in S-phase" EXACT []
synonym: "nuclear cell cycle DNA replication" EXACT []
is_a: GO:0044786 ! cell cycle DNA replication
intersection_of: GO:0006260 ! DNA replication
intersection_of: occurs_in GO:0005634 ! nucleus
intersection_of: part_of GO:0007049 ! cell cycle
relationship: occurs_in GO:0005634 ! nucleus
relationship: part_of GO:0007049 ! cell cycle

[Term]
id: GO:0033261
name: obsolete regulation of S phase
namespace: biological_process
def: "OBSOLETE. A cell cycle process that modulates the rate or extent of the progression through the S phase of the cell cycle." [GOC:dph, GOC:mah, GOC:tb]
comment: This term was made obsolete because cell cycle phases are intervals and so cannot be regulated as such, rather it is the transitions between the phases that are regulated. This term was often also used to annotate genes which should have been annotated to 'regulation of DNA replication', or one of its children.
synonym: "regulation of progression through S phase" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of S phase" EXACT []
synonym: "regulation of S-phase" EXACT []
xref: MetaCyc:PWY-5043
xref: MetaCyc:SALVADEHYPOX-PWY
xref: MetaCyc:SALVPURINE2-PWY
is_obsolete: true
consider: GO:0044770

[Term]
id: GO:0033262
name: regulation of nuclear cell cycle DNA replication
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle." [GOC:mtg_cell_cycle]
synonym: "regulation of DNA replication during S phase" RELATED [GOC:dph, GOC:tb]
synonym: "regulation of DNA replication involved in S phase" EXACT []
synonym: "regulation of DNA replication involved in S-phase" EXACT []
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0090329 ! regulation of DNA-dependent DNA replication
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0033260 ! nuclear DNA replication
relationship: regulates GO:0033260 ! nuclear DNA replication

[Term]
id: GO:0033263
name: CORVET complex
namespace: cellular_component
def: "A multimeric protein complex that acts as an endosomal tethering complex (CORVET = class C core vacuole/endosome tethering) by cooperating with Rab GTPases to capture endosomal vesicles and trap them prior to the action of SNAREs; the complex is involved in endo-lysosomal biogenesis and required for transport between endosome and vacuole. The Saccharomyces cerevisiae complex contains Vps8p, Vps3p, Pep5p, Vps16p, Pep3p, and Vps33p." [PMID:17488625]
is_a: GO:0043234 ! protein complex
is_a: GO:0044440 ! endosomal part

[Term]
id: GO:0033264
name: obsolete bontoxilysin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevins, SNAP25 or syntaxin. No detected action on small molecule substrates." [EC:3.4.24.69]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "BoNT" RELATED [EC:3.4.24.69]
synonym: "bontoxilysin activity" EXACT []
synonym: "botulinum neurotoxin activity" EXACT []
xref: EC:3.4.24.69
xref: MetaCyc:3.4.24.69-RXN
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0033265
name: choline binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with choline, the amine 2-hydroxy-N,N,N-trimethylethanaminium." [CHEBI:15354, GOC:mlg]
is_a: GO:0043178 ! alcohol binding
is_a: GO:0050997 ! quaternary ammonium group binding
is_a: GO:0070405 ! ammonium ion binding

[Term]
id: GO:0033266
name: choline-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of choline across a membrane." [GOC:mlg]
is_a: GO:0015220 ! choline transmembrane transporter activity
is_a: GO:0019829 ! cation-transporting ATPase activity
is_a: GO:0031263 ! amine-transporting ATPase activity

[Term]
id: GO:0033267
name: axon part
namespace: cellular_component
def: "A part of an axon, a cell projection of a neuron." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: goantislim_grouping
subset: gocheck_do_not_annotate
xref: NIF_Subcellular:sao280355188
is_a: GO:0044463 ! cell projection part
is_a: GO:0097458 ! neuron part
intersection_of: GO:0005575 ! cellular_component
intersection_of: part_of GO:0030424 ! axon
relationship: part_of GO:0030424 ! axon

[Term]
id: GO:0033268
name: node of Ranvier
namespace: cellular_component
def: "An axon part that is a gap in the myelin where voltage-gated sodium channels cluster and saltatory conduction is executed." [GOC:mh]
synonym: "node of Ranvier axon" RELATED [NIF_Subcellular:sao-188049490]
xref: NIF_Subcellular:birnlex_1152_2
xref: Wikipedia:Nodes_of_Ranvier
is_a: GO:0033267 ! axon part
relationship: part_of GO:0044304 ! main axon

[Term]
id: GO:0033269
name: internode region of axon
namespace: cellular_component
def: "An axon part that is located between the nodes of Ranvier and surrounded by compact myelin sheath." [GOC:mah, GOC:mh]
synonym: "internode" EXACT []
xref: NIF_Subcellular:sao206157942
is_a: GO:0033267 ! axon part
relationship: part_of GO:0044304 ! main axon

[Term]
id: GO:0033270
name: paranode region of axon
namespace: cellular_component
def: "An axon part that is located adjacent to the nodes of Ranvier and surrounded by lateral loop portions of myelin sheath." [GOC:mah, GOC:mh, NIF_Subcellular:sao936144858]
synonym: "paranode" EXACT []
xref: NIF_Subcellular:sao234066064
xref: NIF_Subcellular:sao936144858
is_a: GO:0033267 ! axon part
relationship: part_of GO:0044304 ! main axon

[Term]
id: GO:0033271
name: myo-inositol phosphate transport
namespace: biological_process
def: "The directed movement of any phosphorylated myo-inositol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015748 ! organophosphate ester transport
is_a: GO:0015791 ! polyol transport

[Term]
id: GO:0033272
name: myo-inositol hexakisphosphate transport
namespace: biological_process
def: "The directed movement of myo-inositol hexakisphosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:17401, GOC:mah]
synonym: "phytate transport" EXACT []
is_a: GO:0033271 ! myo-inositol phosphate transport

[Term]
id: GO:0033273
name: response to vitamin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin stimulus." [GOC:sl]
is_a: GO:0007584 ! response to nutrient

[Term]
id: GO:0033274
name: response to vitamin B2
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B2 stimulus." [GOC:sl]
synonym: "response to riboflavin" EXACT []
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033273 ! response to vitamin

[Term]
id: GO:0033275
name: actin-myosin filament sliding
namespace: biological_process
def: "The sliding movement of actin thin filaments and myosin thick filaments past each other." [GOC:pf]
synonym: "actin filament sliding" RELATED []
is_a: GO:0070252 ! actin-mediated cell contraction

[Term]
id: GO:0033276
name: transcription factor TFTC complex
namespace: cellular_component
def: "A protein complex that does not contain either a TATA-binding protein (TBP) or a TBP-like factor, but is composed of several TAFIIs and other proteins, including a histone acetyltransferase. This complex is able to nucleate transcription initiation by RNA polymerase II, can mediate transcriptional activation, and has histone acetyltransferase activity." [PMID:10373431, PMID:9603525]
is_a: GO:0070461 ! SAGA-type complex
is_a: GO:0090575 ! RNA polymerase II transcription factor complex
relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme

[Term]
id: GO:0033277
name: abortive mitotic cell cycle
namespace: biological_process
def: "A cell cycle in which mitosis is begun and progresses normally through the end of anaphase, but not completed, resulting in a cell with increased ploidy." [GOC:mah, PMID:9573008]
comment: Note that this term should be used only for abortive mitotic events that occur normally, e.g. during megakaryocyte differentiation; it should not be used for incomplete mitosis resulting from mutation or other abnormal occurrences. Note that this term should not be confused with 'endomitotic cell cycle ; GO:0007113', which describes a process in which no mitotic spindle forms.
synonym: "abortive mitosis" RELATED []
is_a: GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0033278
name: cell proliferation in midbrain
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population in the midbrain." [GO_REF:0000021, GOC:dgf]
comment: This term was added by GO_REF:0000021.
synonym: "cell proliferation in mesencephalon" EXACT []
synonym: "mesencepahalic cell proliferation" RELATED []
is_a: GO:0061351 ! neural precursor cell proliferation
relationship: part_of GO:0030901 ! midbrain development

[Term]
id: GO:0033280
name: response to vitamin D
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus." [GOC:sl]
synonym: "response to calciferol" EXACT []
synonym: "response to cholecalciferol" NARROW []
synonym: "response to ergocalciferol" NARROW []
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033273 ! response to vitamin
is_a: GO:0033993 ! response to lipid
is_a: GO:0097305 ! response to alcohol

[Term]
id: GO:0033281
name: TAT protein transport complex
namespace: cellular_component
def: "A complex of three proteins integral to the cytoplasmic membrane of bacteria and membranes of organelles derived from bacteria (chloroplasts and mitochondria) involved in membrane transport of folded proteins." [GOC:pamgo_curators]
subset: gosubset_prok
synonym: "TAT protein secretion complex" NARROW []
synonym: "TAT protein translocation system complex" NARROW []
synonym: "Twin-arginine translocation complex" NARROW []
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0033282
name: protein C inhibitor-acrosin complex
namespace: cellular_component
def: "A heterodimeric protein complex of protein C inhibitor (SERPINA5) and acrosin; formation of the complex inhibits the protease activity of acrosin." [GOC:pr, PMID:11120760, PMID:7521127]
synonym: "PCI-ACR complex" EXACT [PR:000003652, PR:000014685]
synonym: "PCI-acrosin complex" EXACT [PR:000014685]
synonym: "plasma serine protease inhibitor-acrosin complex" EXACT [PR:000014685]
synonym: "serpin A5-acrosin complex" EXACT [PR:000014685]
synonym: "SERPINA5-acrosin complex" EXACT [PR:000014685]
is_a: GO:0044433 ! cytoplasmic vesicle part
is_a: GO:0097180 ! serine protease inhibitor complex
is_a: GO:0097223 ! sperm part
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0002080 ! acrosomal membrane

[Term]
id: GO:0033283
name: organic acid-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + organic acid(out/in) = ADP + phosphate + organic acid(in/out)." [GOC:mlg]
is_a: GO:0005342 ! organic acid transmembrane transporter activity
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances

[Term]
id: GO:0033284
name: carboxylic acid-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + carboxylic acid(out/in) = ADP + phosphate + carboxylic acid(in/out)." [GOC:mlg]
is_a: GO:0033283 ! organic acid-transporting ATPase activity
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity

[Term]
id: GO:0033285
name: monocarboxylic acid-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + monocarboxylic acid(out/in) = ADP + phosphate + monocarboxylic acid(in/out)." [GOC:mlg]
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:0033284 ! carboxylic acid-transporting ATPase activity

[Term]
id: GO:0033286
name: ectoine-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + ectoine(out/in) = ADP + phosphate + ectoine(in/out)." [GOC:mlg]
xref: RHEA:32790
is_a: GO:0033285 ! monocarboxylic acid-transporting ATPase activity
is_a: GO:0051471 ! ectoine transmembrane transporter activity

[Term]
id: GO:0033287
name: hydroxyectoine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of hydroxyectoine from one side of the membrane to the other." [GOC:mlg]
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:0015665 ! alcohol transmembrane transporter activity
relationship: part_of GO:0033308 ! hydroxyectoine transport

[Term]
id: GO:0033288
name: hydroxyectoine-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + hydroxyectoine(out/in) = ADP + phosphate + hydroxyectoine(in/out)." [GOC:mlg]
is_a: GO:0033285 ! monocarboxylic acid-transporting ATPase activity
is_a: GO:0033287 ! hydroxyectoine transmembrane transporter activity

[Term]
id: GO:0033289
name: intraconoid microtubule
namespace: cellular_component
def: "A microtubule located such that it threads through the conoid and projects through the polar ring." [GOC:mah, PMID:11901169, PMID:16518471]
is_a: GO:0005874 ! microtubule
relationship: part_of GO:0020007 ! apical complex

[Term]
id: GO:0033290
name: eukaryotic 48S preinitiation complex
namespace: cellular_component
alt_id: GO:0016283
def: "A protein complex composed of the small ribosomal subunit, eIF3, eIF1A, methionyl-initiatior methionine and a capped mRNA. The complex is initially positioned at the 5'-end of the capped mRNA." [GOC:hjd, PMID:15145049]
synonym: "eukaryotic 48S initiation complex" RELATED []
synonym: "eukaryotic 48S pre-initiation complex" EXACT []
is_a: GO:0070993 ! translation preinitiation complex
relationship: has_part GO:0022627 ! cytosolic small ribosomal subunit

[Term]
id: GO:0033291
name: eukaryotic 80S initiation complex
namespace: cellular_component
def: "A protein complex composed of the large and small ribosomal subunits, methionyl-initiatior tRNA, and the capped mRNA. The initiator tRNA is positioned at the ribosomal P site at the AUG codon corresponding to the beginning of the coding region." [GOC:hjd, PMID:15145049]
is_a: GO:0070992 ! translation initiation complex

[Term]
id: GO:0033292
name: T-tubule organization
namespace: biological_process
def: "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of the T-tubule. A T-tubule is an invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril." [GOC:dph, GOC:jl, GOC:mah]
synonym: "T-tubule organisation" EXACT [GOC:mah]
synonym: "T-tubule organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0044802 ! single-organism membrane organization
relationship: part_of GO:0007009 ! plasma membrane organization
relationship: part_of GO:0055001 ! muscle cell development

[Term]
id: GO:0033293
name: monocarboxylic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a monocarboxylic acid, any organic acid containing one carboxyl (COOH) group or anion (COO-)." [GOC:mah]
subset: gosubset_prok
is_a: GO:0031406 ! carboxylic acid binding

[Term]
id: GO:0033294
name: ectoine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with ectoine, 1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid." [GOC:mah]
is_a: GO:0033293 ! monocarboxylic acid binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding

[Term]
id: GO:0033295
name: hydroxyectoine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with hydroxyectoine." [GOC:mlg]
is_a: GO:0033293 ! monocarboxylic acid binding
is_a: GO:0043178 ! alcohol binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding

[Term]
id: GO:0033296
name: rhamnose binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the D- or L-enantiomer of rhamnose." [CHEBI:26546, GOC:mah]
subset: gosubset_prok
is_a: GO:0048029 ! monosaccharide binding

[Term]
id: GO:0033297
name: rhamnose-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + rhamnose(out/in) = ADP + phosphate + rhamnose(in/out)." [GOC:mlg]
is_a: GO:0015153 ! rhamnose transmembrane transporter activity
is_a: GO:0015407 ! monosaccharide-transporting ATPase activity
is_a: GO:0015608 ! carbohydrate-importing ATPase activity

[Term]
id: GO:0033298
name: contractile vacuole organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a contractile vacuole. A specialized vacuole that fills with water from the cytoplasm and then discharges this externally by the opening of contractile vacuole pores." [GOC:mah]
synonym: "contractile vacuole organisation" EXACT [GOC:mah]
synonym: "contractile vacuole organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0007033 ! vacuole organization
is_a: GO:0016050 ! vesicle organization

[Term]
id: GO:0033299
name: secretion of lysosomal enzymes
namespace: biological_process
def: "The controlled release of lysosomal enzymes by a cell." [GOC:mah]
is_a: GO:0009306 ! protein secretion

[Term]
id: GO:0033300
name: dehydroascorbic acid transporter activity
namespace: molecular_function
def: "Enables the directed movement of dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:17242]
synonym: "dehydroascorbate transporter activity" EXACT []
xref: Reactome:REACT_103876 "Dehydroascorbate transport across the plasma membrane, Danio rerio"
xref: Reactome:REACT_104859 "Dehydroascorbate transport across the plasma membrane, Rattus norvegicus"
xref: Reactome:REACT_105499 "Dehydroascorbate transport across the plasma membrane, Taeniopygia guttata"
xref: Reactome:REACT_11168 "Dehydroascorbate transport across the plasma membrane, Homo sapiens"
xref: Reactome:REACT_111999 "Dehydroascorbate transport across the plasma membrane, Drosophila melanogaster"
xref: Reactome:REACT_112454 "Dehydroascorbate transport across the plasma membrane, Dictyostelium discoideum"
xref: Reactome:REACT_112481 "Dehydroascorbate transport across the plasma membrane, Arabidopsis thaliana"
xref: Reactome:REACT_112492 "Dehydroascorbate transport across the plasma membrane, Caenorhabditis elegans"
xref: Reactome:REACT_112507 "Dehydroascorbate transport across the plasma membrane, Mycobacterium tuberculosis"
xref: Reactome:REACT_113721 "Dehydroascorbate transport across the plasma membrane, Oryza sativa"
xref: Reactome:REACT_114727 "Dehydroascorbate transport across the plasma membrane, Plasmodium falciparum"
xref: Reactome:REACT_28737 "Dehydroascorbate transport across the plasma membrane, Gallus gallus"
xref: Reactome:REACT_85776 "Dehydroascorbate transport across the plasma membrane, Canis familiaris"
xref: Reactome:REACT_89148 "Dehydroascorbate transport across the plasma membrane, Mus musculus"
xref: Reactome:REACT_89589 "Dehydroascorbate transport across the plasma membrane, Xenopus tropicalis"
xref: Reactome:REACT_91207 "Dehydroascorbate transport across the plasma membrane, Bos taurus"
is_a: GO:0051183 ! vitamin transporter activity
relationship: part_of GO:0070837 ! dehydroascorbic acid transport

[Term]
id: GO:0033301
name: cell cycle comprising mitosis without cytokinesis
namespace: biological_process
def: "A mitotic cell cycle in which mitosis is completed but cytokinesis does not occur, resulting in a cell containing multiple nuclei each with a chromosomal complement of the original ploidy (usually 2N)." [GOC:expert_vm, GOC:mah]
comment: Note that this term should be used for naturally occurring instances of mitosis without cytokinesis, e.g. in the tapetum of flowers and in a number of lower eukaryotes; it should not be used for abnormal events such as may occur in cancers.
is_a: GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0033302
name: quercetin O-glucoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving O-glucosylated derivatives of quercetin." [CHEBI:28299, CHEBI:28529, GOC:mah, MetaCyc:PWY-5321]
synonym: "quercetin O-glucoside metabolism" EXACT []
is_a: GO:0016137 ! glycoside metabolic process
is_a: GO:0051552 ! flavone metabolic process

[Term]
id: GO:0033303
name: quercetin O-glucoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways leading to the formation of O-glucosylated derivatives of quercetin." [CHEBI:28299, CHEBI:28529, GOC:mah, MetaCyc:PWY-5321]
synonym: "quercetin O-glucoside anabolism" EXACT []
synonym: "quercetin O-glucoside biosynthesis" EXACT []
synonym: "quercetin O-glucoside formation" EXACT []
synonym: "quercetin O-glucoside synthesit" EXACT []
xref: MetaCyc:PWY-5321
is_a: GO:0016138 ! glycoside biosynthetic process
is_a: GO:0033302 ! quercetin O-glucoside metabolic process
is_a: GO:0051553 ! flavone biosynthetic process

[Term]
id: GO:0033304
name: chlorophyll a metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving chlorophyll a." [CHEBI:18230, GOC:mah]
subset: gosubset_prok
synonym: "chlorophyll a metabolism" EXACT []
is_a: GO:0015994 ! chlorophyll metabolic process

[Term]
id: GO:0033305
name: chlorophyll a biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways leading to the formation of chlorophyll a." [CHEBI:18230, GOC:mah]
subset: gosubset_prok
synonym: "chlorophyll a anabolism" EXACT []
synonym: "chlorophyll a biosynthesis" EXACT []
synonym: "chlorophyll a formation" EXACT []
synonym: "chlorophyll a synthesis" EXACT []
is_a: GO:0015995 ! chlorophyll biosynthetic process
is_a: GO:0033304 ! chlorophyll a metabolic process

[Term]
id: GO:0033306
name: phytol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phytol, (2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-ol." [CHEBI:17327, GOC:mah]
synonym: "phytol metabolism" EXACT []
is_a: GO:0016101 ! diterpenoid metabolic process
is_a: GO:0034308 ! primary alcohol metabolic process
is_a: GO:1903173 ! fatty alcohol metabolic process

[Term]
id: GO:0033307
name: phytol salvage
namespace: biological_process
def: "A process that generates phytol, (2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-ol, from derivatives of it without de novo synthesis." [GOC:mah, MetaCyc:PWY-5107]
synonym: "phytol salvage pathway" EXACT []
xref: MetaCyc:PWY-5107
is_a: GO:0033520 ! phytol biosynthetic process
is_a: GO:0043094 ! cellular metabolic compound salvage

[Term]
id: GO:0033308
name: hydroxyectoine transport
namespace: biological_process
def: "The directed movement of hydroxyectoine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mlg]
subset: gosubset_prok
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0033309
name: SBF transcription complex
namespace: cellular_component
def: "A protein complex that binds to the Swi4/6 cell cycle box (SCB) promoter element, consensus sequence CRCGAAA, and activates transcription during the G1/S transition of the cell cycle. In Saccharomyces, the complex contains a heterodimer of the DNA binding protein Swi6p and the activator Swi4p, and is associated with additional proteins known as Whi5p and Msa1p." [GOC:mah, PMID:11206552, PMID:15838511, PMID:18160399, PMID:7917338]
synonym: "SBF complex" EXACT [GOC:mah]
is_a: GO:0090575 ! RNA polymerase II transcription factor complex

[Term]
id: GO:0033310
name: chlorophyll a catabolic process
namespace: biological_process
def: "The chemical reactions and pathways leading to the breakdown of chlorophyll a." [CHEBI:18230, GOC:mah]
subset: gosubset_prok
synonym: "chlorophyll a breakdown" EXACT []
synonym: "chlorophyll a catabolism" EXACT []
synonym: "chlorophyll a degradation" EXACT []
xref: MetaCyc:PWY-5086
xref: MetaCyc:PWY-5098
is_a: GO:0015996 ! chlorophyll catabolic process
is_a: GO:0033304 ! chlorophyll a metabolic process

[Term]
id: GO:0033311
name: chlorophyll a biosynthetic process via phytyl diphosphate
namespace: biological_process
def: "The chemical reactions and pathways leading to the formation of chlorophyll a, via the intermediate phytyl diphosphate." [CHEBI:18230, GOC:mah, MetaCyc:PWY-5086]
subset: gosubset_prok
synonym: "chlorophyll a anabolism via phytyl diphosphate" EXACT []
synonym: "chlorophyll a biosynthesis via phytyl diphosphate" EXACT []
synonym: "chlorophyll a biosynthetic process via phytyl-PP" EXACT []
synonym: "chlorophyll a formation via phytyl chlorophyll a formation via phytyl-PP" EXACT []
synonym: "chlorophyll a synthesis via phytyl diphosphate" EXACT []
xref: MetaCyc:PWY-5086
is_a: GO:0033305 ! chlorophyll a biosynthetic process

[Term]
id: GO:0033312
name: chlorophyll a biosynthetic process via geranylgeranyl-chlorophyll a
namespace: biological_process
def: "The chemical reactions and pathways leading to the formation of chlorophyll a, via the intermediate geranylgeranyl-chlorophyll a." [CHEBI:18230, GOC:mah, MetaCyc:PWY-5064]
subset: gosubset_prok
synonym: "chlorophyll a anabolism via geranylgeranyl-chlorophyll a" EXACT []
synonym: "chlorophyll a biosynthesis via geranylgeranyl-chlorophyll a" EXACT []
synonym: "chlorophyll a formation via geranylgeranyl-chlorophyll a" EXACT []
synonym: "chlorophyll a synthesis via geranylgeranyl-chlorophyll a" EXACT []
xref: MetaCyc:PWY-5064
is_a: GO:0033305 ! chlorophyll a biosynthetic process

[Term]
id: GO:0033313
name: meiotic cell cycle checkpoint
namespace: biological_process
def: "A cell cycle checkpoint that ensures accurate chromosome replication and segregation by preventing progression through a meiotic cell cycle until conditions are suitable for the cell to proceed to the next stage." [GOC:mtg_cell_cycle]
is_a: GO:0000075 ! cell cycle checkpoint
is_a: GO:1903046 ! meiotic cell cycle process
intersection_of: GO:0000075 ! cell cycle checkpoint
intersection_of: part_of GO:0051321 ! meiotic cell cycle
relationship: part_of GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0033314
name: mitotic DNA replication checkpoint
namespace: biological_process
alt_id: GO:0031574
def: "A cell cycle checkpoint that acts during a mitotic cell cycle and prevents the initiation of mitosis until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome." [GOC:mtg_cell_cycle]
synonym: "mitotic cell cycle DNA replication checkpoint" EXACT []
synonym: "S-M checkpoint" EXACT []
synonym: "S-M DNA replication checkpoint" EXACT []
synonym: "S-phase checkpoint" BROAD []
is_a: GO:0000076 ! DNA replication checkpoint
is_a: GO:0044774 ! mitotic DNA integrity checkpoint
is_a: GO:0044818 ! mitotic G2/M transition checkpoint
intersection_of: GO:0000076 ! DNA replication checkpoint
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0033315
name: meiotic DNA replication checkpoint
namespace: biological_process
def: "A cell cycle checkpoint that acts during a meiotic cell cycle and prevents the initiation of cell division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the haploid genome." [GOC:mtg_cell_cycle]
synonym: "meiotic cell cycle DNA replication checkpoint" EXACT []
is_a: GO:0000076 ! DNA replication checkpoint
is_a: GO:0044778 ! meiotic DNA integrity checkpoint
is_a: GO:1901994 ! negative regulation of meiotic cell cycle phase transition
intersection_of: GO:0000076 ! DNA replication checkpoint
intersection_of: part_of GO:0051321 ! meiotic cell cycle
relationship: part_of GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0033316
name: meiotic spindle assembly checkpoint
namespace: biological_process
def: "A cell cycle checkpoint that delays the metaphase/anaphase transition of a meiotic cell cycle until the spindle is correctly assembled and chromosomes are attached to the spindle." [GOC:mah]
is_a: GO:0044779 ! meiotic spindle checkpoint
is_a: GO:0071173 ! spindle assembly checkpoint
intersection_of: GO:0071173 ! spindle assembly checkpoint
intersection_of: part_of GO:0051321 ! meiotic cell cycle
relationship: part_of GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0033317
name: pantothenate biosynthetic process from valine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pantothenate, the anion of pantothenic acid, from other compounds, including valine." [GOC:mah, MetaCyc:PANTO-PWY, MetaCyc:PWY-3921]
synonym: "pantothenate anabolism from valine" EXACT []
synonym: "pantothenate biosynthesis from valine" EXACT []
synonym: "pantothenate formation from valine" EXACT []
synonym: "pantothenate synthesis from valine" EXACT []
xref: MetaCyc:PANTO-PWY
is_a: GO:0006573 ! valine metabolic process
is_a: GO:0015940 ! pantothenate biosynthetic process

[Term]
id: GO:0033318
name: pantothenate biosynthetic process from 2-dehydropantolactone
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pantothenate, the anion of pantothenic acid, from other compounds, including 2-dehydropantolactone." [GOC:mah, MetaCyc:PWY-3961]
synonym: "pantothenate anabolism from 2-oxypantoyl lactone" EXACT []
synonym: "pantothenate biosynthesis from 2-oxypantoyl lactone" EXACT []
synonym: "pantothenate biosynthetic process from 2-oxypantoyl lactone" EXACT []
synonym: "pantothenate formation from 2-oxypantoyl lactone" EXACT []
synonym: "pantothenate synthesis from 2-oxypantoyl lactone" EXACT []
xref: MetaCyc:PWY-3961
is_a: GO:0015940 ! pantothenate biosynthetic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process

[Term]
id: GO:0033319
name: UDP-D-xylose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving UDP-D-xylose, uridinediphosphoxylose, a substance composed of xylose in glycosidic linkage with uridine diphosphate." [GOC:mah]
synonym: "UDP-D-xylose metabolism" EXACT []
is_a: GO:0009225 ! nucleotide-sugar metabolic process

[Term]
id: GO:0033320
name: UDP-D-xylose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of UDP-D-xylose, uridinediphosphoxylose, a substance composed of xylose in glycosidic linkage with uridine diphosphate." [GOC:mah, MetaCyc:PWY-4821]
synonym: "UDP-D-xylose anabolism" EXACT []
synonym: "UDP-D-xylose biosynthesis" EXACT []
synonym: "UDP-D-xylose formation" EXACT []
synonym: "UDP-D-xylose synthesis" EXACT []
xref: MetaCyc:PWY-4821
is_a: GO:0009226 ! nucleotide-sugar biosynthetic process
is_a: GO:0033319 ! UDP-D-xylose metabolic process

[Term]
id: GO:0033321
name: homomethionine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving homomethionine, a non-protein amino acid synthesized from methionine via chain elongation." [GOC:mah, MetaCyc:PWY-1186]
synonym: "homomethionine metabolism" EXACT []
is_a: GO:0000096 ! sulfur amino acid metabolic process
is_a: GO:1901605 ! alpha-amino acid metabolic process

[Term]
id: GO:0033322
name: homomethionine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of homomethionine, a non-protein amino acid synthesized from methionine via chain elongation." [GOC:mah, MetaCyc:PWY-1186]
synonym: "homomethionine anabolism" EXACT []
synonym: "homomethionine biosynthesis" EXACT []
synonym: "homomethionine formation" EXACT []
synonym: "homomethionine synthesis" EXACT []
xref: MetaCyc:PWY-1186
is_a: GO:0000097 ! sulfur amino acid biosynthetic process
is_a: GO:0033321 ! homomethionine metabolic process
is_a: GO:1901607 ! alpha-amino acid biosynthetic process

[Term]
id: GO:0033323
name: choline biosynthetic process via CDP-choline
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of choline (2-hydroxyethyltrimethylammonium), via the intermediate CDP-choline." [GOC:mah, MetaCyc:PWY-3561]
subset: gosubset_prok
synonym: "choline anabolism via CDP-choline" EXACT []
synonym: "choline biosynthesis via CDP-choline" EXACT []
synonym: "choline formation via CDP-choline" EXACT []
synonym: "choline synthesis via CDP-choline" EXACT []
xref: MetaCyc:PWY-3561
xref: MetaCyc:PWY-4762
is_a: GO:0042425 ! choline biosynthetic process

[Term]
id: GO:0033324
name: choline biosynthetic process via N-monomethylethanolamine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of choline (2-hydroxyethyltrimethylammonium), via the intermediate N-monomethylethanolamine." [GOC:mah, MetaCyc:PWY-3542]
subset: gosubset_prok
synonym: "choline anabolism via N-monomethylethanolamine" EXACT []
synonym: "choline biosynthesis via N-monomethylethanolamine" EXACT []
synonym: "choline formation via N-monomethylethanolamine" EXACT []
synonym: "choline synthesis via N-monomethylethanolamine" EXACT []
xref: MetaCyc:PWY-3542
xref: MetaCyc:PWY-4762
is_a: GO:0042425 ! choline biosynthetic process

[Term]
id: GO:0033325
name: choline biosynthetic process via phosphoryl-ethanolamine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of choline (2-hydroxyethyltrimethylammonium), via the intermediate phosphoryl-ethanolamine." [GOC:mah, MetaCyc:PWY-3385]
subset: gosubset_prok
synonym: "choline anabolism via phosphoryl-ethanolamine" EXACT []
synonym: "choline biosynthesis via phosphoryl-ethanolamine" EXACT []
synonym: "choline formation via phosphoryl-ethanolamine" EXACT []
synonym: "choline synthesis via phosphoryl-ethanolamine" EXACT []
xref: MetaCyc:PWY-3385
xref: MetaCyc:PWY-4762
is_a: GO:0042425 ! choline biosynthetic process

[Term]
id: GO:0033326
name: cerebrospinal fluid secretion
namespace: biological_process
def: "The regulated release of cerebrospinal fluid (CSF) from the choroid plexus of the lateral, third and fourth ventricles. The cerebrospinal fluid is a clear liquid that located within the ventricles, spinal canal, and subarachnoid spaces." [GOC:ln, http://users.ahsc.arizona.edu/davis/csf.htm, PMID:10716451]
synonym: "CSF secretion" EXACT []
is_a: GO:0007589 ! body fluid secretion
is_a: GO:0032941 ! secretion by tissue

[Term]
id: GO:0033327
name: Leydig cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a Leydig cell. A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis." [GOC:ln, PMID:12050120]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0030154 ! cell differentiation
is_a: GO:0044702 ! single organism reproductive process
relationship: part_of GO:0008584 ! male gonad development

[Term]
id: GO:0033328
name: peroxisome membrane targeting sequence binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane." [GOC:rb, PMID:15133130, PMID:17020786]
synonym: "mPTS binding" EXACT []
synonym: "peroxisomal membrane protein (PMP) targeting signal (mPTS) binding" EXACT [PMID:14709540]
synonym: "PMP targeting signal (mPTS) binding" EXACT [PMID:14709540]
synonym: "PMP targeting signal binding" EXACT [PMID:14709540]
is_a: GO:0000268 ! peroxisome targeting sequence binding

[Term]
id: GO:0033329
name: kaempferol O-glucoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving O-glucosylated derivatives of kaempferol." [CHEBI:30200, GOC:mah, MetaCyc:PWY-5320]
synonym: "kaempferol O-glucoside metabolism" EXACT []
is_a: GO:0016137 ! glycoside metabolic process
is_a: GO:0051552 ! flavone metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process

[Term]
id: GO:0033330
name: kaempferol O-glucoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways leading to the formation of O-glucosylated derivatives of kaempferol." [CHEBI:30200, GOC:mah, MetaCyc:PWY-5320]
synonym: "kaempferol O-glucoside anabolism" EXACT []
synonym: "kaempferol O-glucoside biosynthesis" EXACT []
synonym: "kaempferol O-glucoside formation" EXACT []
synonym: "kaempferol O-glucoside synthesit" EXACT []
xref: MetaCyc:PWY-5320
is_a: GO:0016138 ! glycoside biosynthetic process
is_a: GO:0033329 ! kaempferol O-glucoside metabolic process
is_a: GO:0051553 ! flavone biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process

[Term]
id: GO:0033331
name: ent-kaurene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ent-kaur-16-ene. Ent-kaurene is a tetracyclic diterpenoid that is a precursor of several plant isoprenoids, including gibberellins." [GOC:mah, MetaCyc:PWY-5032, PMID:17064690]
subset: gosubset_prok
synonym: "ent-kaurene metabolism" EXACT []
is_a: GO:0042214 ! terpene metabolic process

[Term]
id: GO:0033332
name: ent-kaurene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ent-kaurene. Ent-kaurene is a tetracyclic diterpenoid that is a precursor of several plant isoprenoids, including gibberellins." [GOC:mah, MetaCyc:PWY-5032, PMID:17064690]
subset: gosubset_prok
synonym: "ent-kaurene anabolism" EXACT []
synonym: "ent-kaurene biosynthesis" EXACT []
synonym: "ent-kaurene formation" EXACT []
synonym: "ent-kaurene synthesis" EXACT []
xref: MetaCyc:PWY-5032
xref: MetaCyc:PWY-5035
is_a: GO:0033331 ! ent-kaurene metabolic process
is_a: GO:0046246 ! terpene biosynthetic process

[Term]
id: GO:0033333
name: fin development
namespace: biological_process
def: "The process whose specific outcome is the progression of a fin over time, from its formation to the mature structure." [GOC:dgh]
is_a: GO:0048736 ! appendage development

[Term]
id: GO:0033334
name: fin morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a fin are generated and organized." [GOC:dgh]
is_a: GO:0035107 ! appendage morphogenesis
relationship: part_of GO:0033333 ! fin development

[Term]
id: GO:0033335
name: anal fin development
namespace: biological_process
def: "The process whose specific outcome is the progression of the anal fin over time, from its formation to the mature structure." [GOC:dgh]
is_a: GO:0033338 ! medial fin development

[Term]
id: GO:0033336
name: caudal fin development
namespace: biological_process
def: "The process whose specific outcome is the progression of the caudal fin over time, from its formation to the mature structure." [GOC:dgh]
is_a: GO:0033338 ! medial fin development

[Term]
id: GO:0033337
name: dorsal fin development
namespace: biological_process
def: "The process whose specific outcome is the progression of the dorsal fin over time, from its formation to the mature structure." [GOC:dgh]
is_a: GO:0033338 ! medial fin development

[Term]
id: GO:0033338
name: medial fin development
namespace: biological_process
def: "The process whose specific outcome is the progression of a medial fin over time, from its formation to the mature structure." [GOC:dgh]
is_a: GO:0033333 ! fin development

[Term]
id: GO:0033339
name: pectoral fin development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pectoral fin over time, from its formation to the mature structure." [GOC:dgh]
is_a: GO:0033333 ! fin development

[Term]
id: GO:0033340
name: pelvic fin development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pelvic fin over time, from its formation to the mature structure." [GOC:dgh]
is_a: GO:0033333 ! fin development

[Term]
id: GO:0033341
name: regulation of collagen binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of collagen binding." [GOC:mah]
is_a: GO:0043393 ! regulation of protein binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0005518 ! collagen binding
relationship: regulates GO:0005518 ! collagen binding

[Term]
id: GO:0033342
name: negative regulation of collagen binding
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of collagen binding." [GOC:mah]
synonym: "down regulation of collagen binding" EXACT []
synonym: "down-regulation of collagen binding" EXACT []
synonym: "downregulation of collagen binding" EXACT []
synonym: "inhibition of collagen binding" NARROW []
is_a: GO:0032091 ! negative regulation of protein binding
is_a: GO:0033341 ! regulation of collagen binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0005518 ! collagen binding
relationship: negatively_regulates GO:0005518 ! collagen binding

[Term]
id: GO:0033343
name: positive regulation of collagen binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of collagen binding." [GOC:mah]
synonym: "activation of collagen binding" NARROW []
synonym: "stimulation of collagen binding" NARROW []
synonym: "up regulation of collagen binding" EXACT []
synonym: "up-regulation of collagen binding" EXACT []
synonym: "upregulation of collagen binding" EXACT []
is_a: GO:0032092 ! positive regulation of protein binding
is_a: GO:0033341 ! regulation of collagen binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0005518 ! collagen binding
relationship: positively_regulates GO:0005518 ! collagen binding

[Term]
id: GO:0033344
name: cholesterol efflux
namespace: biological_process
def: "The directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle." [GOC:sart]
synonym: "cholesterol export" EXACT []
is_a: GO:0030301 ! cholesterol transport

[Term]
id: GO:0033345
name: asparagine catabolic process via L-aspartate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate L-aspartate." [GOC:mah]
xref: MetaCyc:ASPARAGINE-DEG1-PWY
is_a: GO:0006530 ! asparagine catabolic process

[Term]
id: GO:0033346
name: asparagine catabolic process via 2-oxosuccinamate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate 2-oxosuccinamate." [GOC:mah, MetaCyc:PWY-4002]
xref: MetaCyc:PWY-4002
is_a: GO:0006530 ! asparagine catabolic process

[Term]
id: GO:0033347
name: tetrose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a tetrose, any monosaccharide with a chain of four carbon atoms in the molecule." [GOC:mah]
subset: gosubset_prok
synonym: "tetrose metabolism" EXACT []
is_a: GO:0005996 ! monosaccharide metabolic process

[Term]
id: GO:0033348
name: tetrose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a tetrose, any monosaccharide with a chain of four carbon atoms in the molecule." [GOC:mah]
synonym: "tetrose anabolism" EXACT []
synonym: "tetrose biosynthesis" EXACT []
synonym: "tetrose formation" EXACT []
synonym: "tetrose synthesis" EXACT []
is_a: GO:0033347 ! tetrose metabolic process
is_a: GO:0046364 ! monosaccharide biosynthetic process

[Term]
id: GO:0033349
name: apiose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving apiose, the branched tetrose 3-C-(hydroxymethyl)-D-glycero-tetrose." [CHEBI:16689, GOC:mah]
synonym: "apiose metabolism" EXACT []
is_a: GO:0033347 ! tetrose metabolic process

[Term]
id: GO:0033350
name: apiose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of apiose, the branched tetrose 3-C-(hydroxymethyl)-D-glycero-tetrose." [CHEBI:16689, GOC:mah]
synonym: "apiose anabolism" EXACT []
synonym: "apiose biosynthesis" EXACT []
synonym: "apiose formation" EXACT []
synonym: "apiose synthesis" EXACT []
is_a: GO:0033348 ! tetrose biosynthetic process
is_a: GO:0033349 ! apiose metabolic process

[Term]
id: GO:0033351
name: UDP-D-apiose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving UDP-D-apiose, uridinediphosphoapiose, a substance composed of apiose in glycosidic linkage with uridine diphosphate." [GOC:mah]
synonym: "UDP-D-apiose metabolism" EXACT []
is_a: GO:0009225 ! nucleotide-sugar metabolic process

[Term]
id: GO:0033352
name: UDP-D-apiose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of UDP-D-apiose, uridinediphosphoapicose, a substance composed of apiose in glycosidic linkage with uridine diphosphate." [GOC:mah, MetaCyc:PWY-5113]
synonym: "UDP-D-apiose anabolism" EXACT []
synonym: "UDP-D-apiose biosynthesis" EXACT []
synonym: "UDP-D-apiose formation" EXACT []
synonym: "UDP-D-apiose synthesis" EXACT []
xref: MetaCyc:PWY-4821
xref: MetaCyc:PWY-5113
is_a: GO:0009226 ! nucleotide-sugar biosynthetic process
is_a: GO:0033351 ! UDP-D-apiose metabolic process

[Term]
id: GO:0033353
name: S-adenosylmethionine cycle
namespace: biological_process
def: "A cyclic series of interconversions involving S-adenosylmethionine, S-adenosyl-L-homocysteine, L-cysteine, and L-methionine. Couples utilization of the methyl group of SAM with recycling of the homocysteinyl group and regeneration of methionine." [GOC:mah, MetaCyc:PWY-5041]
synonym: "activated methyl cycle" EXACT []
synonym: "SAM cycle" EXACT []
xref: MetaCyc:PWY-5041
is_a: GO:0000096 ! sulfur amino acid metabolic process
is_a: GO:0009066 ! aspartate family amino acid metabolic process
is_a: GO:0009069 ! serine family amino acid metabolic process
is_a: GO:0046498 ! S-adenosylhomocysteine metabolic process
is_a: GO:0046500 ! S-adenosylmethionine metabolic process
relationship: has_part GO:0008898 ! S-adenosylmethionine-homocysteine S-methyltransferase activity

[Term]
id: GO:0033354
name: chlorophyll cycle
namespace: biological_process
def: "A cyclic series of interconversions involving chlorophyll a, chlorophyll b and several chlorophyllide intermediates." [GOC:mah, MetaCyc:PWY-5068]
xref: MetaCyc:PWY-5068
is_a: GO:0015994 ! chlorophyll metabolic process

[Term]
id: GO:0033355
name: ascorbate glutathione cycle
namespace: biological_process
def: "A cyclic series of interconversions involving L-ascorbate and glutathione that scavenges hydrogen peroxide and reduces it to water, with concomitant oxidation of NADPH." [GOC:mah, MetaCyc:PWY-2261]
synonym: "hydrogen peroxide detoxification" RELATED []
xref: MetaCyc:PWY-2261
is_a: GO:0006749 ! glutathione metabolic process
is_a: GO:0019852 ! L-ascorbic acid metabolic process
is_a: GO:0042744 ! hydrogen peroxide catabolic process

[Term]
id: GO:0033356
name: UDP-L-arabinose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving UDP-L-arabinose, uridinediphosphoarabinose, a substance composed of arabinose in glycosidic linkage with uridine diphosphate." [GOC:mah]
synonym: "UDP-L-arabinose metabolism" EXACT []
is_a: GO:0009225 ! nucleotide-sugar metabolic process

[Term]
id: GO:0033357
name: L-arabinose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-arabinose, arabino-pentose." [CHEBI:22599, GOC:mah]
synonym: "L-arabinose anabolism" EXACT []
synonym: "L-arabinose biosynthesis" EXACT []
synonym: "L-arabinose formation" EXACT []
synonym: "L-arabinose synthesis" EXACT []
is_a: GO:0019567 ! arabinose biosynthetic process
is_a: GO:0046373 ! L-arabinose metabolic process

[Term]
id: GO:0033358
name: UDP-L-arabinose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of UDP-L-arabinose, uridinediphosphoarabinose, a substance composed of arabinose in glycosidic linkage with uridine diphosphate." [GOC:mah, MetaCyc:PWY-82]
synonym: "UDP-L-arabinose anabolism" EXACT []
synonym: "UDP-L-arabinose biosynthesis" EXACT []
synonym: "UDP-L-arabinose formation" EXACT []
synonym: "UDP-L-arabinose synthesis" EXACT []
xref: MetaCyc:PWY-63
xref: MetaCyc:PWY-82
is_a: GO:0009226 ! nucleotide-sugar biosynthetic process
is_a: GO:0033356 ! UDP-L-arabinose metabolic process

[Term]
id: GO:0033359
name: lysine biosynthetic process via diaminopimelate and N-succinyl-2-amino-6-ketopimelate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lysine, via the intermediates diaminopimelate and N-succinyl-2-amino-6-ketopimelate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in four enzymatic steps." [GOC:mah, MetaCyc:DAPLYSINESYN-PWY-]
subset: gosubset_prok
synonym: "lysine anabolism via diaminopimelate and N-succinyl-2-amino-6-ketopimelate" EXACT []
synonym: "lysine biosynthesis via diaminopimelic acid and N-succinyl-2-amino-6-ketopimelate" EXACT []
synonym: "lysine biosynthetic process via diaminopimelic acid and N-succinyl-2-amino-6-ketopimelate" EXACT []
synonym: "lysine formation via diaminopimelate and N-succinyl-2-amino-6-ketopimelate" EXACT []
synonym: "lysine synthesis via diaminopimelate and N-succinyl-2-amino-6-ketopimelate" EXACT []
xref: MetaCyc:DAPLYSINESYN-PWY
is_a: GO:0009089 ! lysine biosynthetic process via diaminopimelate

[Term]
id: GO:0033360
name: lysine biosynthetic process via diaminopimelate and L-2-acetamido-6-oxoheptanedioate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lysine, via the intermediates diaminopimelate and L-2-acetamido-6-oxoheptanedioate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in four enzymatic steps." [GOC:mah, MetaCyc:PWY-2941]
subset: gosubset_prok
synonym: "lysine anabolism via diaminopimelate and L-2-acetamido-6-oxoheptanedioate" EXACT []
synonym: "lysine biosynthesis via diaminopimelic acid and L-2-acetamido-6-oxoheptanedioate" EXACT []
synonym: "lysine biosynthetic process via diaminopimelic acid and L-2-acetamido-6-oxoheptanedioate" EXACT []
synonym: "lysine formation via diaminopimelate and L-2-acetamido-6-oxoheptanedioate" EXACT []
synonym: "lysine synthesis via diaminopimelate and L-2-acetamido-6-oxoheptanedioate" EXACT []
xref: MetaCyc:PWY-2941
is_a: GO:0009089 ! lysine biosynthetic process via diaminopimelate

[Term]
id: GO:0033361
name: lysine biosynthetic process via diaminopimelate, dehydrogenase pathway
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in a single enzymatic step." [GOC:mah, GOC:pr, MetaCyc:PWY-2942]
subset: gosubset_prok
synonym: "lysine anabolism via diaminopimelate, dehydrogenase pathway" EXACT []
synonym: "lysine biosynthesis via diaminopimelic acid, dehydrogenase pathway" EXACT []
synonym: "lysine formation via diaminopimelate, dehydrogenase pathway" EXACT []
synonym: "lysine synthesis via diaminopimelate, dehydrogenase pathway" EXACT []
xref: MetaCyc:PWY-2942
is_a: GO:0009089 ! lysine biosynthetic process via diaminopimelate
relationship: has_part GO:0047850 ! diaminopimelate dehydrogenase activity

[Term]
id: GO:0033362
name: lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in two enzymatic steps." [GOC:mah, GOC:pr, MetaCyc:PWY-5097]
subset: gosubset_prok
synonym: "lysine anabolism via diaminopimelate, diaminopimelate-aminotransferase pathway" EXACT []
synonym: "lysine biosynthesis via diaminopimelate, diaminopimelate-aminotransferase pathway" EXACT []
synonym: "lysine formation via diaminopimelate, diaminopimelate-aminotransferase pathway" EXACT []
synonym: "lysine synthesis via diaminopimelate, diaminopimelate-aminotransferase pathway" EXACT []
xref: MetaCyc:PWY-5097
is_a: GO:0009089 ! lysine biosynthetic process via diaminopimelate
relationship: has_part GO:0008837 ! diaminopimelate epimerase activity
relationship: has_part GO:0010285 ! L,L-diaminopimelate aminotransferase activity

[Term]
id: GO:0033363
name: secretory granule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion." [GOC:mah]
synonym: "secretory granule organisation" EXACT [GOC:mah]
synonym: "secretory granule organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0016050 ! vesicle organization
relationship: part_of GO:0010256 ! endomembrane system organization

[Term]
id: GO:0033364
name: mast cell secretory granule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule in a mast cell. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion." [GOC:mah]
synonym: "mast cell secretory granule maturation" RELATED []
synonym: "mast cell secretory granule organisation" EXACT [GOC:mah]
synonym: "mast cell secretory granule organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0033363 ! secretory granule organization

[Term]
id: GO:0033365
name: protein localization to organelle
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within an organelle." [GOC:mah]
synonym: "protein localisation to organelle" EXACT [GOC:mah]
synonym: "protein localization in organelle" EXACT [GOC:mah]
is_a: GO:0034613 ! cellular protein localization

[Term]
id: GO:0033366
name: protein localization to secretory granule
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a secretory granule." [GOC:mah]
synonym: "protein localisation in secretory granule" EXACT [GOC:mah]
synonym: "protein localization in secretory granule" EXACT [GOC:curators]
is_a: GO:0033365 ! protein localization to organelle

[Term]
id: GO:0033367
name: protein localization to mast cell secretory granule
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a secretory granule in a mast cell." [GOC:mah]
synonym: "protein localisation in mast cell secretory granule" EXACT [GOC:mah]
synonym: "protein localization in mast cell secretory granule" EXACT [GOC:curators]
is_a: GO:0033366 ! protein localization to secretory granule
relationship: part_of GO:0033364 ! mast cell secretory granule organization

[Term]
id: GO:0033368
name: protease localization to mast cell secretory granule
namespace: biological_process
def: "Any process in which a protease is transported to, or maintained in, a location within a secretory granule in a mast cell." [GOC:mah]
synonym: "protease localisation in mast cell secretory granule" EXACT [GOC:mah]
synonym: "protease localization in mast cell secretory granule" EXACT [GOC:curators]
is_a: GO:0033367 ! protein localization to mast cell secretory granule

[Term]
id: GO:0033369
name: establishment of protein localization to mast cell secretory granule
namespace: biological_process
def: "The directed movement of a protein to a location within a secretory granule in a mast cell." [GOC:mah]
synonym: "establishment of protein localisation in mast cell secretory granule" EXACT [GOC:mah]
synonym: "establishment of protein localization in mast cell secretory granule" EXACT [GOC:curators]
is_a: GO:0006886 ! intracellular protein transport
is_a: GO:1902582 ! single-organism intracellular transport
relationship: part_of GO:0033367 ! protein localization to mast cell secretory granule

[Term]
id: GO:0033370
name: maintenance of protein location in mast cell secretory granule
namespace: biological_process
def: "A process in which a protein is maintained in a secretory granule in a mast cell and prevented from moving elsewhere." [GOC:dph, GOC:mah, GOC:tb]
synonym: "maintenance of protein localization in mast cell secretory granule" RELATED [GOC:dph, GOC:tb]
synonym: "mast cell protein retention" EXACT []
is_a: GO:0045185 ! maintenance of protein location
is_a: GO:0051651 ! maintenance of location in cell
relationship: part_of GO:0033367 ! protein localization to mast cell secretory granule

[Term]
id: GO:0033371
name: T cell secretory granule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule in a T cell. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion." [GOC:mah]
synonym: "T cell secretory granule organisation" EXACT [GOC:mah]
synonym: "T cell secretory granule organization and biogenesis" RELATED [GOC:mah]
synonym: "T lymphocyte secretory granule organization" EXACT []
synonym: "T-cell secretory granule organization" EXACT []
synonym: "T-lymphocyte secretory granule maturation" RELATED []
synonym: "T-lymphocyte secretory granule organization" EXACT []
is_a: GO:0033363 ! secretory granule organization

[Term]
id: GO:0033372
name: establishment of protease localization to mast cell secretory granule
namespace: biological_process
def: "The directed movement of a protease to a location within a secretory granule in a mast cell." [GOC:mah]
synonym: "establishment of protease localisation in mast cell secretory granule" EXACT [GOC:mah]
synonym: "establishment of protease localization in mast cell secretory granule" EXACT [GOC:curators]
is_a: GO:0033369 ! establishment of protein localization to mast cell secretory granule
relationship: part_of GO:0033368 ! protease localization to mast cell secretory granule

[Term]
id: GO:0033373
name: maintenance of protease location in mast cell secretory granule
namespace: biological_process
def: "A process in which a protease is maintained in a secretory granule in a mast cell and prevented from moving elsewhere." [GOC:dph, GOC:mah, GOC:tb]
synonym: "maintenance of protease localization in mast cell secretory granule" RELATED [GOC:dph, GOC:tb]
synonym: "mast cell protease retention" EXACT []
is_a: GO:0033370 ! maintenance of protein location in mast cell secretory granule
relationship: part_of GO:0033368 ! protease localization to mast cell secretory granule

[Term]
id: GO:0033374
name: protein localization to T cell secretory granule
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a secretory granule in a T cell." [GOC:mah]
synonym: "protein localisation in T cell secretory granule" EXACT [GOC:mah]
synonym: "protein localization in T cell secretory granule" EXACT [GOC:curators]
synonym: "protein localization in T lymphocyte secretory granule" EXACT []
synonym: "protein localization in T-cell secretory granule" EXACT []
synonym: "protein localization in T-lymphocyte secretory granule" EXACT []
is_a: GO:0033366 ! protein localization to secretory granule
relationship: part_of GO:0033371 ! T cell secretory granule organization

[Term]
id: GO:0033375
name: protease localization to T cell secretory granule
namespace: biological_process
def: "Any process in which a protease is transported to, or maintained in, a location within a secretory granule in a T cell." [GOC:mah]
synonym: "protease localisation in T cell secretory granule" EXACT [GOC:mah]
synonym: "protease localization in T cell secretory granule" EXACT [GOC:curators]
synonym: "protease localization in T lymphocyte secretory granule" EXACT []
synonym: "protease localization in T-cell secretory granule" EXACT []
synonym: "protease localization in T-lymphocyte secretory granule" EXACT []
is_a: GO:0033374 ! protein localization to T cell secretory granule

[Term]
id: GO:0033376
name: establishment of protein localization to T cell secretory granule
namespace: biological_process
def: "The directed movement of a protein to a location within a secretory granule in a T cell." [GOC:mah]
synonym: "establishment of protein localisation in T cell secretory granule" EXACT [GOC:mah]
synonym: "establishment of protein localization in T cell secretory granule" EXACT [GOC:curators]
synonym: "establishment of protein localization in T lymphocyte secretory granule" EXACT []
synonym: "establishment of protein localization in T-cell secretory granule" EXACT []
synonym: "establishment of protein localization in T-lymphocyte secretory granule" EXACT []
is_a: GO:0006886 ! intracellular protein transport
is_a: GO:1902582 ! single-organism intracellular transport
relationship: part_of GO:0033374 ! protein localization to T cell secretory granule

[Term]
id: GO:0033377
name: maintenance of protein location in T cell secretory granule
namespace: biological_process
def: "A process in which a protein is maintained in a secretory granule in a T cell and prevented from moving elsewhere." [GOC:dph, GOC:mah, GOC:tb]
synonym: "maintenance of protein localization in T cell secretory granule" RELATED [GOC:dph, GOC:tb]
synonym: "maintenance of protein localization in T lymphocyte secretory granule" EXACT []
synonym: "maintenance of protein localization in T-cell secretory granule" EXACT []
synonym: "maintenance of protein localization in T-lymphocyte secretory granule" EXACT []
is_a: GO:0045185 ! maintenance of protein location
is_a: GO:0051651 ! maintenance of location in cell
relationship: part_of GO:0033374 ! protein localization to T cell secretory granule

[Term]
id: GO:0033378
name: establishment of protease localization to T cell secretory granule
namespace: biological_process
def: "The directed movement of a protease to a location within a secretory granule in a T cell." [GOC:mah]
synonym: "establishment of protease localisation in T cell secretory granule" EXACT [GOC:mah]
synonym: "establishment of protease localization in T cell secretory granule" EXACT [GOC:curators]
synonym: "establishment of protease localization in T lymphocyte secretory granule" EXACT []
synonym: "establishment of protease localization in T-cell secretory granule" EXACT []
synonym: "establishment of protease localization in T-lymphocyte secretory granule" EXACT []
is_a: GO:0033376 ! establishment of protein localization to T cell secretory granule
relationship: part_of GO:0033375 ! protease localization to T cell secretory granule

[Term]
id: GO:0033379
name: maintenance of protease location in T cell secretory granule
namespace: biological_process
def: "A process in which a protease is maintained in a secretory granule in a T cell and prevented from moving elsewhere." [GOC:dph, GOC:mah, GOC:tb]
synonym: "maintenance of protease localization in T cell secretory granule" RELATED [GOC:dph, GOC:tb]
synonym: "maintenance of protease localization in T lymphocyte secretory granule" EXACT []
synonym: "maintenance of protease localization in T-cell secretory granule" EXACT []
synonym: "maintenance of protease localization in T-lymphocyte secretory granule" EXACT []
is_a: GO:0033377 ! maintenance of protein location in T cell secretory granule
relationship: part_of GO:0033375 ! protease localization to T cell secretory granule

[Term]
id: GO:0033380
name: granzyme B localization to T cell secretory granule
namespace: biological_process
def: "Any process in which the protease granzyme B is transported to, or maintained in, a location within a secretory granule in a T cell." [GOC:mah]
synonym: "granzyme B localisation in T cell secretory granule" EXACT [GOC:mah]
synonym: "granzyme B localization in T cell secretory granule" EXACT [GOC:curators]
synonym: "granzyme B localization in T lymphocyte secretory granule" EXACT []
synonym: "granzyme B localization in T-cell secretory granule" EXACT []
synonym: "granzyme B localization in T-lymphocyte secretory granule" EXACT []
is_a: GO:0033375 ! protease localization to T cell secretory granule

[Term]
id: GO:0033381
name: establishment of granzyme B localization to T cell secretory granule
namespace: biological_process
def: "The directed movement of the protease granzyme B to a location within a secretory granule in a T cell." [GOC:mah]
synonym: "establishment of granzyme B localisation in T cell secretory granule" EXACT [GOC:mah]
synonym: "establishment of granzyme B localization in T cell secretory granule" EXACT [GOC:curators]
synonym: "establishment of granzyme B localization in T lymphocyte secretory granule" EXACT []
synonym: "establishment of granzyme B localization in T-cell secretory granule" EXACT []
synonym: "establishment of granzyme B localization in T-lymphocyte secretory granule" EXACT []
synonym: "T-lymphocyte secretory granule storage of granzyme B" RELATED []
is_a: GO:0033378 ! establishment of protease localization to T cell secretory granule
relationship: part_of GO:0033380 ! granzyme B localization to T cell secretory granule

[Term]
id: GO:0033382
name: maintenance of granzyme B location in T cell secretory granule
namespace: biological_process
def: "A process in which the protease granyme B is maintained in a secretory granule in a T cell and prevented from moving elsewhere." [GOC:mah]
synonym: "maintenance of granzyme B localization in T cell secretory granule" RELATED [GOC:dph, GOC:tb]
synonym: "maintenance of granzyme B localization in T lymphocyte secretory granule" EXACT []
synonym: "maintenance of granzyme B localization in T-cell secretory granule" EXACT []
synonym: "maintenance of granzyme B localization in T-lymphocyte secretory granule" EXACT []
is_a: GO:0033379 ! maintenance of protease location in T cell secretory granule
relationship: part_of GO:0033380 ! granzyme B localization to T cell secretory granule

[Term]
id: GO:0033383
name: geranyl diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving geranyl diphosphate, the universal precursor of the monoterpenes." [GOC:mah, MetaCyc:PWY-5122]
synonym: "geranyl diphosphate metabolism" EXACT []
synonym: "geranyldiphosphate metabolic process" EXACT []
is_a: GO:0006644 ! phospholipid metabolic process
is_a: GO:0006721 ! terpenoid metabolic process

[Term]
id: GO:0033384
name: geranyl diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of geranyl diphosphate." [GOC:mah, MetaCyc:PWY-5122]
synonym: "geranyl diphosphate anabolism" EXACT []
synonym: "geranyl diphosphate biosynthesis" EXACT []
synonym: "geranyl diphosphate formation" EXACT []
synonym: "geranyl diphosphate synthesis" EXACT []
synonym: "geranyldiphosphate biosynthetic process" EXACT []
xref: MetaCyc:PWY-5122
is_a: GO:0008654 ! phospholipid biosynthetic process
is_a: GO:0016114 ! terpenoid biosynthetic process
is_a: GO:0033383 ! geranyl diphosphate metabolic process

[Term]
id: GO:0033385
name: geranylgeranyl diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving geranylgeranyl diphosphate, a polyprenol compound involved in the biosynthesis of a variety of terpenoids including chlorophylls, carotenoids, tocopherols, plastoquinones, and the plant hormones gibberellins." [GOC:mah, MetaCyc:PWY-5120]
synonym: "geranylgeranyl diphosphate metabolism" EXACT []
synonym: "geranylgeranyldiphosphate metabolic process" EXACT []
is_a: GO:0006644 ! phospholipid metabolic process
is_a: GO:0006721 ! terpenoid metabolic process

[Term]
id: GO:0033386
name: geranylgeranyl diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of geranylgeranyl diphosphate." [GOC:mah, MetaCyc:PWY-5120]
synonym: "geranylgeranyl diphosphate anabolism" EXACT []
synonym: "geranylgeranyl diphosphate biosynthesis" EXACT []
synonym: "geranylgeranyl diphosphate formation" EXACT []
synonym: "geranylgeranyl diphosphate synthesis" EXACT []
xref: MetaCyc:PWY-5120
xref: MetaCyc:PWY-5121
is_a: GO:0008654 ! phospholipid biosynthetic process
is_a: GO:0016114 ! terpenoid biosynthetic process
is_a: GO:0033385 ! geranylgeranyl diphosphate metabolic process

[Term]
id: GO:0033387
name: putrescine biosynthetic process from ornithine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane by decarboxylation of ornithine." [GOC:mah, MetaCyc:PWY-46]
synonym: "putrescine anabolism from ornithine" EXACT []
synonym: "putrescine biosynthesis from ornithine" EXACT []
synonym: "putrescine formation from ornithine" EXACT []
synonym: "putrescine synthesis from ornithine" EXACT []
is_a: GO:0006591 ! ornithine metabolic process
is_a: GO:0009446 ! putrescine biosynthetic process
is_a: GO:0044711 ! single-organism biosynthetic process

[Term]
id: GO:0033388
name: putrescine biosynthetic process from arginine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from other compounds, including arginine." [GOC:mah, MetaCyc:PWY-46]
subset: gosubset_prok
synonym: "putrescine anabolism from arginine" EXACT []
synonym: "putrescine biosynthesis from arginine" EXACT []
synonym: "putrescine formation from arginine" EXACT []
synonym: "putrescine synthesis from arginine" EXACT []
is_a: GO:0006525 ! arginine metabolic process
is_a: GO:0009446 ! putrescine biosynthetic process
is_a: GO:0044711 ! single-organism biosynthetic process

[Term]
id: GO:0033389
name: putrescine biosynthetic process from arginine, using agmatinase
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from other compounds, including arginine; in this pathway, arginine is converted to agmatine, and agmatine is converted to putrescine in a single enzymatic step." [GOC:mah, MetaCyc:PWY-40]
subset: gosubset_prok
synonym: "putrescine anabolism from arginine, using agmatinase" EXACT []
synonym: "putrescine biosynthesis from arginine, using agmatinase" EXACT []
synonym: "putrescine formation from arginine, using agmatinase" EXACT []
synonym: "putrescine synthesis from arginine, using agmatinase" EXACT []
is_a: GO:0033388 ! putrescine biosynthetic process from arginine

[Term]
id: GO:0033390
name: putrescine biosynthetic process from arginine via N-carbamoylputrescine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from other compounds, including arginine, via the intermediate N-carbamoylputrescine; in this pathway, arginine is converted to agmatine, and agmatine is converted to putrescine in two single enzymatic steps." [GOC:mah, MetaCyc:PWY-43]
subset: gosubset_prok
synonym: "putrescine anabolism from arginine via N-carbamoylputrescine" EXACT []
synonym: "putrescine biosynthesis from arginine via N-carbamoylputrescine" EXACT []
synonym: "putrescine formation from arginine via N-carbamoylputrescine" EXACT []
synonym: "putrescine synthesis from arginine via N-carbamoylputrescine" EXACT []
is_a: GO:0033388 ! putrescine biosynthetic process from arginine

[Term]
id: GO:0033391
name: chromatoid body
namespace: cellular_component
def: "A ribonucleoprotein complex found in the cytoplasm of male germ cells, composed of exceedingly thin filaments that are consolidated into a compact mass or into dense strands of varying thickness that branch to form an irregular network. Contains mRNAs, miRNAs, and protein components involved in miRNA processing (such as Argonaute proteins and the endonuclease Dicer) and in RNA decay (such as the decapping enzyme DCP1a and GW182)." [PMID:17183363]
is_a: GO:0036464 ! cytoplasmic ribonucleoprotein granule

[Term]
id: GO:0033392
name: obsolete actin homodimerization activity
namespace: molecular_function
def: "OBSOLETE. Interacting selectively and non-covalently with an identical actin monomer to form a homodimer." [GOC:mah]
comment: This term was made obsolete because it was added in error; formation of an actin dimer is simply a transient step in the polymerization of actin. Also, this term may not represent a real molecular function in GO, but rather that a gene product (actin itself) is part of an actin homodimer transient protein complex.
subset: gosubset_prok
synonym: "actin dimerization activity" BROAD []
synonym: "actin homodimerization activity" EXACT []
synonym: "actin polymerizing activity" RELATED []
is_obsolete: true

[Term]
id: GO:0033393
name: homogalacturonan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of homogalacturonan, a pectidic polymer, characterized by a backbone of 1,4-linked alpha-D-GalpA residues that can be methyl-esterified at C-6 and carry acetyl groups on O-2 and O-3." [GOC:mah]
subset: gosubset_prok
synonym: "homogalacturonan breakdown" EXACT []
synonym: "homogalacturonan catabolism" EXACT []
synonym: "homogalacturonan degradation" EXACT []
xref: MetaCyc:PWY-1081
is_a: GO:0000272 ! polysaccharide catabolic process
is_a: GO:0010394 ! homogalacturonan metabolic process

[Term]
id: GO:0033394
name: beta-alanine biosynthetic process via 1,3 diaminopropane
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of beta-alanine via the intermediate 1,3 diaminopropane." [GOC:mah, MetaCyc:PWY-3981]
synonym: "beta-alanine anabolism via 1,3 diaminopropane" EXACT []
synonym: "beta-alanine biosynthesis via 1,3 diaminopropane" EXACT []
synonym: "beta-alanine formation via 1,3 diaminopropane" EXACT []
synonym: "beta-alanine synthesis via 1,3 diaminopropane" EXACT []
xref: MetaCyc:PWY-3981
is_a: GO:0019483 ! beta-alanine biosynthetic process

[Term]
id: GO:0033395
name: beta-alanine biosynthetic process via 3-hydroxypropionate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of beta-alanine via the intermediate 3-hydroxypropionate." [GOC:mah, MetaCyc:PWY-3941]
synonym: "beta-alanine anabolism via 3-hydroxypropionate" EXACT []
synonym: "beta-alanine biosynthesis via 3-hydroxypropionate" EXACT []
synonym: "beta-alanine formation via 3-hydroxypropionate" EXACT []
synonym: "beta-alanine synthesis via 3-hydroxypropionate" EXACT []
xref: MetaCyc:PWY-3941
is_a: GO:0019483 ! beta-alanine biosynthetic process

[Term]
id: GO:0033396
name: beta-alanine biosynthetic process via 3-ureidopropionate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of beta-alanine via the intermediate 3-ureidopropionate." [GOC:mah, MetaCyc:PWY-3982]
synonym: "beta-alanine anabolism via 3-ureidopropionate" EXACT []
synonym: "beta-alanine formation via 3-ureidopropionate" EXACT []
synonym: "beta-alanine synthesis via 3-ureidopropionate" EXACT []
xref: MetaCyc:PWY-3982
is_a: GO:0019483 ! beta-alanine biosynthetic process

[Term]
id: GO:0033397
name: zeatin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving zeatin, 2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol." [CHEBI:15333, GOC:mah]
synonym: "zeatin metabolism" EXACT []
is_a: GO:0009690 ! cytokinin metabolic process
is_a: GO:0072521 ! purine-containing compound metabolic process

[Term]
id: GO:0033398
name: zeatin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of zeatin, 2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol." [CHEBI:15333, GOC:mah]
subset: gosubset_prok
synonym: "zeatin anabolism" EXACT []
synonym: "zeatin biosynthesis" EXACT []
synonym: "zeatin formation" EXACT []
synonym: "zeatin synthesis" EXACT []
is_a: GO:0009691 ! cytokinin biosynthetic process
is_a: GO:0033397 ! zeatin metabolic process
is_a: GO:0072522 ! purine-containing compound biosynthetic process

[Term]
id: GO:0033399
name: cis-zeatin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cis-zeatin, (2Z)-2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol." [CHEBI:12800, GOC:mah]
synonym: "cis-zeatin metabolism" EXACT []
is_a: GO:0033397 ! zeatin metabolic process

[Term]
id: GO:0033400
name: trans-zeatin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving trans-zeatin, (2E)-2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol." [CHEBI:16522, GOC:mah]
synonym: "trans-zeatin metabolism" EXACT []
is_a: GO:0033397 ! zeatin metabolic process

[Term]
id: GO:0033401
name: UUU codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a UUU codon." [GOC:mah]
comment: Note that in the standard genetic code, TTT codes for phenylalanine.
synonym: "phenylalanine tRNA" RELATED [GOC:hjd, GOC:mah]
synonym: "TTT codon-amino acid adaptor activity" EXACT [GOC:hjd]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033402
name: UUC codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a UUC codon." [GOC:mah]
comment: Note that in the standard genetic code, TTC codes for phenylalanine.
synonym: "phenylalanine tRNA" RELATED [GOC:hjd, GOC:mah]
synonym: "TTC codon-amino acid adaptor activity" EXACT [GOC:hjd]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033403
name: UUA codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a UUA codon." [GOC:mah]
comment: Note that in the standard genetic code, TTA codes for leucine.
synonym: "leucine tRNA" RELATED [GOC:hjd, GOC:mah]
synonym: "TTA codon-amino acid adaptor activity" EXACT [GOC:hjd]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033404
name: UUG codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a UUG codon." [GOC:mah]
comment: Note that in the standard genetic code, TTG codes for leucine.
synonym: "leucine tRNA" RELATED [GOC:hjd, GOC:mah]
synonym: "TTG codon-amino acid adaptor activity" EXACT [GOC:hjd]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033405
name: UCU codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a UCU codon." [GOC:mah]
comment: Note that in the standard genetic code, TCT codes for serine.
synonym: "serine tRNA" RELATED [GOC:hjd, GOC:mah]
synonym: "TCT codon-amino acid adaptor activity" EXACT [GOC:hjd]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033406
name: UCC codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a UCC codon." [GOC:mah]
comment: Note that in the standard genetic code, TCC codes for serine.
synonym: "serine tRNA" RELATED [GOC:hjd, GOC:mah]
synonym: "TCC codon-amino acid adaptor activity" EXACT [GOC:hjd]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033407
name: UCA codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a UCA codon." [GOC:mah]
comment: Note that in the standard genetic code, TCA codes for serine.
synonym: "serine tRNA" RELATED [GOC:hjd, GOC:mah]
synonym: "TCA codon-amino acid adaptor activity" EXACT [GOC:hjd]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033408
name: UCG codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a UCG codon." [GOC:mah]
comment: Note that in the standard genetic code, TCG codes for serine.
synonym: "serine tRNA" RELATED [GOC:hjd, GOC:mah]
synonym: "TCG codon-amino acid adaptor activity" EXACT [GOC:hjd]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033409
name: UAU codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a UAU codon." [GOC:mah]
comment: Note that in the standard genetic code, TAT codes for tyrosine.
synonym: "TAT codon-amino acid adaptor activity" EXACT [GOC:hjd]
synonym: "tyrosine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033410
name: UAC codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a UAC codon." [GOC:mah]
comment: Note that in the standard genetic code, TAC codes for tyrosine.
synonym: "TAC codon-amino acid adaptor activity" EXACT [GOC:hjd]
synonym: "tyrosine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033411
name: UAA codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a UAA codon." [GOC:mah]
comment: Note that in the standard genetic code, TAA is a stop codon (ochre) and is not normally read by a tRNA.
synonym: "TAA codon-amino acid adaptor activity" EXACT [GOC:hjd]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033412
name: UAG codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a UAG codon." [GOC:mah]
comment: Note that in the standard genetic code, TAG is a stop codon (amber) and is not normally read by a tRNA.
synonym: "TAG codon-amino acid adaptor activity" EXACT [GOC:hjd]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033413
name: UGU codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a UGU codon." [GOC:mah]
comment: Note that in the standard genetic code, TGT codes for cysteine.
synonym: "cysteine tRNA" RELATED [GOC:hjd, GOC:mah]
synonym: "TGT codon-amino acid adaptor activity" EXACT [GOC:hjd]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033414
name: UGC codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a UGC codon." [GOC:mah]
comment: Note that in the standard genetic code, TGC codes for cysteine.
synonym: "cysteine tRNA" RELATED [GOC:hjd, GOC:mah]
synonym: "TGC codon-amino acid adaptor activity" EXACT [GOC:hjd]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033415
name: UGA codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a UGA codon." [GOC:mah]
comment: Note that in the standard genetic code, TGA is a stop codon (opal) and is not normally read by a tRNA.
synonym: "TGA codon-amino acid adaptor activity" EXACT [GOC:hjd]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033416
name: UGG codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a UGG codon." [GOC:mah]
comment: Note that in the standard genetic code, TGG codes for tryptophan.
synonym: "TGG codon-amino acid adaptor activity" EXACT [GOC:hjd]
synonym: "tryptophan tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033417
name: CUU codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a CUU codon." [GOC:mah]
comment: Note that in the standard genetic code, CTT codes for leucine.
synonym: "CTT codon-amino acid adaptor activity" EXACT [GOC:mah]
synonym: "leucine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033418
name: CUC codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a CUC codon." [GOC:mah]
comment: Note that in the standard genetic code, CTC codes for leucine.
synonym: "CTC codon-amino acid adaptor activity" EXACT [GOC:hjd]
synonym: "leucine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033419
name: CUA codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a CUA codon." [GOC:mah]
comment: Note that in the standard genetic code, CTA codes for leucine.
synonym: "CTA codon-amino acid adaptor activity" EXACT [GOC:mah]
synonym: "leucine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033420
name: CUG codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a CUG codon." [GOC:mah]
comment: Note that in the standard genetic code, CTG codes for leucine.
synonym: "CTG codon-amino acid adaptor activity" EXACT [GOC:hjd]
synonym: "leucine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033421
name: CCU codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a CCU codon." [GOC:mah]
comment: Note that in the standard genetic code, CCT codes for proline.
synonym: "CCT codon-amino acid adaptor activity" EXACT [GOC:hjd]
synonym: "proline tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033422
name: CCC codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a CCC codon." [GOC:mah]
comment: Note that in the standard genetic code, CCC codes for proline.
synonym: "proline tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033423
name: CCA codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a CCA codon." [GOC:mah]
comment: Note that in the standard genetic code, CCA codes for proline.
synonym: "proline tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033424
name: CCG codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a CCG codon." [GOC:mah]
comment: Note that in the standard genetic code, CCG codes for proline.
synonym: "proline tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033425
name: CAU codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a CAU codon." [GOC:mah]
comment: Note that in the standard genetic code, CAT codes for histidine.
synonym: "CAT codon-amino acid adaptor activity" EXACT [GOC:hjd]
synonym: "histidine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033426
name: CAC codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a CAC codon." [GOC:mah]
comment: Note that in the standard genetic code, CAC codes for histidine.
synonym: "histidine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033427
name: CAA codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a CAA codon." [GOC:mah]
comment: Note that in the standard genetic code, CAA codes for glutamine.
synonym: "glutamine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033428
name: CAG codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a CAG codon." [GOC:mah]
comment: Note that in the standard genetic code, CAG codes for glutamine.
synonym: "glutamine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033429
name: CGU codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a CGU codon." [GOC:mah]
comment: Note that in the standard genetic code, CGT codes for arginine.
synonym: "arginine tRNA" RELATED [GOC:hjd, GOC:mah]
synonym: "CGT codon-amino acid adaptor activity" EXACT [GOC:hjd]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033430
name: CGC codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a CGC codon." [GOC:mah]
comment: Note that in the standard genetic code, CGC codes for arginine.
synonym: "arginine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033431
name: CGA codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a CGA codon." [GOC:mah]
comment: Note that in the standard genetic code, CGA codes for arginine.
synonym: "arginine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033432
name: CGG codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a CGG codon." [GOC:mah]
comment: Note that in the standard genetic code, CGG codes for arginine.
synonym: "arginine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033433
name: AUU codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes an AUU codon." [GOC:mah]
comment: Note that in the standard genetic code, ATT codes for isoleucine.
synonym: "ATT codon-amino acid adaptor activity" EXACT [GOC:hjd]
synonym: "isoleucine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033434
name: AUC codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes an AUC codon." [GOC:mah]
comment: Note that in the standard genetic code, ATC codes for isoleucine.
synonym: "ATC codon-amino acid adaptor activity" EXACT [GOC:hjd]
synonym: "isoleucine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033435
name: AUA codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes an AUA codon." [GOC:mah]
comment: Note that in the standard genetic code, ATA codes for isoleucine.
synonym: "ATA codon-amino acid adaptor activity" EXACT [GOC:hjd]
synonym: "isoleucine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033436
name: AUG codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes an AUG codon." [GOC:mah]
comment: Note that in the standard genetic code, ATG codes for methionine, and is the initiator codon.
synonym: "ATG codon-amino acid adaptor activity" EXACT [GOC:mah]
synonym: "initiator methionine tRNA" RELATED [GOC:hjd, GOC:mah]
synonym: "methionine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033437
name: ACU codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes an ACU codon." [GOC:mah]
comment: Note that in the standard genetic code, ACT codes for threonine.
synonym: "ACT codon-amino acid adaptor activity" EXACT [GOC:mah]
synonym: "threonine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033438
name: ACC codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes an ACC codon." [GOC:mah]
comment: Note that in the standard genetic code, ACC codes for threonine.
synonym: "threonine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033439
name: ACA codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes an ACA codon." [GOC:mah]
comment: Note that in the standard genetic code, ACA codes for threonine.
synonym: "threonine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033440
name: ACG codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes an ACG codon." [GOC:mah]
comment: Note that in the standard genetic code, ACG codes for threonine.
synonym: "threonine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033441
name: AAU codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes an AAU codon." [GOC:mah]
comment: Note that in the standard genetic code, AAT codes for asparagine.
synonym: "AAT codon-amino acid adaptor activity" EXACT [GOC:hjd]
synonym: "asparagine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033442
name: AAC codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes an AAC codon." [GOC:mah]
comment: Note that in the standard genetic code, AAC codes for asparagine.
synonym: "asparagine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033443
name: AAA codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes an AAA codon." [GOC:mah]
comment: Note that in the standard genetic code, AAA codes for lysine.
synonym: "lysine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033444
name: AAG codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes an AAG codon." [GOC:mah]
comment: Note that in the standard genetic code, AAG codes for lysine.
synonym: "lysine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033445
name: AGU codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes an AGU codon." [GOC:mah]
comment: Note that in the standard genetic code, AGT codes for serine.
synonym: "AGT codon-amino acid adaptor activity" EXACT [GOC:mah]
synonym: "serine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033446
name: AGC codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes an AGC codon." [GOC:mah]
comment: Note that in the standard genetic code, AGC codes for serine.
synonym: "serine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033447
name: AGA codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes an AGA codon." [GOC:mah]
comment: Note that in the standard genetic code, AGA codes for arginine.
synonym: "arginine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033448
name: AGG codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes an AGG codon." [GOC:mah]
comment: Note that in the standard genetic code, AGG codes for arginine.
synonym: "arginine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033449
name: GUU codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a GUU codon." [GOC:mah]
comment: Note that in the standard genetic code, GTT codes for valine.
synonym: "GTT codon-amino acid adaptor activity" EXACT [GOC:hjd]
synonym: "valine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033450
name: GUC codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a GUC codon." [GOC:mah]
comment: Note that in the standard genetic code, GTC codes for valine.
synonym: "GTC codon-amino acid adaptor activity" EXACT [GOC:hjd]
synonym: "valine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033451
name: GUA codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a GUA codon." [GOC:mah]
comment: Note that in the standard genetic code, GTA codes for valine.
synonym: "GTA codon-amino acid adaptor activity" EXACT [GOC:hjd]
synonym: "valine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033452
name: GUG codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a GUG codon." [GOC:mah]
comment: Note that in the standard genetic code, GTG codes for valine.
synonym: "GTG codon-amino acid adaptor activity" EXACT [GOC:hjd]
synonym: "valine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033453
name: GCU codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a GCU codon." [GOC:mah]
comment: Note that in the standard genetic code, GCT codes for alanine.
synonym: "alanine tRNA" RELATED [GOC:hjd, GOC:mah]
synonym: "GCT codon-amino acid adaptor activity" EXACT [GOC:hjd]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033454
name: GCC codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a GCC codon." [GOC:mah]
comment: Note that in the standard genetic code, GCC codes for alanine.
synonym: "alanine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033455
name: GCA codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a GCA codon." [GOC:mah]
comment: Note that in the standard genetic code, GCA codes for alanine.
synonym: "alanine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033456
name: GCG codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a GCG codon." [GOC:mah]
comment: Note that in the standard genetic code, GCG codes for alanine.
synonym: "alanine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033457
name: GAU codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a GAU codon." [GOC:mah]
comment: Note that in the standard genetic code, GAT codes for aspartic acid.
synonym: "aspartic acid tRNA" RELATED [GOC:hjd, GOC:mah]
synonym: "GAT codon-amino acid adaptor activity" EXACT [GOC:hjd]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033458
name: GAC codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a GAC codon." [GOC:mah]
comment: Note that in the standard genetic code, GAC codes for aspartic acid.
synonym: "aspartic acid tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033459
name: GAA codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a GAA codon." [GOC:mah]
comment: Note that in the standard genetic code, GAA codes for glutamic acid.
synonym: "glutamic acid tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033460
name: GAG codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a GAG codon." [GOC:mah]
comment: Note that in the standard genetic code, GAG codes for glutamic acid.
synonym: "glutamic acid tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033461
name: GGU codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a GGU codon." [GOC:mah]
comment: Note that in the standard genetic code, GGT codes for glycine.
synonym: "GGT codon-amino acid adaptor activity" EXACT [GOC:hjd]
synonym: "glycine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033462
name: GGC codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a GGC codon." [GOC:mah]
comment: Note that in the standard genetic code, GGC codes for glycine.
synonym: "glycine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033463
name: GGA codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a GGA codon." [GOC:mah]
comment: Note that in the standard genetic code, GGA codes for glycine.
synonym: "glycine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033464
name: GGG codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a GGG codon." [GOC:mah]
comment: Note that in the standard genetic code, GGG codes for glycine.
synonym: "glycine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033465
name: cis-zeatin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cis-zeatin, (2Z)-2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol." [CHEBI:12800, GOC:mah]
subset: gosubset_prok
synonym: "cis-zeatin anabolism" EXACT []
synonym: "cis-zeatin biosynthesis" EXACT []
synonym: "cis-zeatin formation" EXACT []
synonym: "cis-zeatin synthesis" EXACT []
xref: MetaCyc:PWY-2781
is_a: GO:0033398 ! zeatin biosynthetic process
is_a: GO:0033399 ! cis-zeatin metabolic process

[Term]
id: GO:0033466
name: trans-zeatin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of trans-zeatin, (2E)-2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol." [CHEBI:16522, GOC:mah]
subset: gosubset_prok
synonym: "trans-zeatin anabolism" EXACT []
synonym: "trans-zeatin biosynthesis" EXACT []
synonym: "trans-zeatin formation" EXACT []
synonym: "trans-zeatin synthesis" EXACT []
xref: MetaCyc:PWY-2681
is_a: GO:0033398 ! zeatin biosynthetic process
is_a: GO:0033400 ! trans-zeatin metabolic process

[Term]
id: GO:0033467
name: CMP-keto-3-deoxy-D-manno-octulosonic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving CMP-keto-3-deoxy-D-manno-octulosonic acid, a substance composed of the acidic sugar 3-deoxy-D-manno-octulosonic acid in glycosidic linkage with cytidine monophosphate." [GOC:mah, MetaCyc:PWY-5111]
synonym: "CMP-KDO metabolic process" EXACT []
synonym: "CMP-keto-3-deoxy-D-manno-octulosonic acid metabolism" EXACT []
synonym: "CMP-ketodeoxyoctanoate metabolic process" RELATED [ISBN:0198506732]
is_a: GO:0009225 ! nucleotide-sugar metabolic process

[Term]
id: GO:0033468
name: CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of CMP-keto-3-deoxy-D-manno-octulosonic acid, a substance composed of the acidic sugar 3-deoxy-D-manno-octulosonic acid in glycosidic linkage with cytidine monophosphate." [GOC:mah, MetaCyc:PWY-5111]
subset: gosubset_prok
synonym: "CMP-KDO biosynthesis" EXACT []
synonym: "CMP-KDO biosynthetic process" EXACT []
synonym: "CMP-keto-3-deoxy-D-manno-octulosonic acid anabolism" EXACT []
synonym: "CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthesis" EXACT []
synonym: "CMP-keto-3-deoxy-D-manno-octulosonic acid formation" EXACT []
synonym: "CMP-keto-3-deoxy-D-manno-octulosonic acid synthesis" EXACT []
synonym: "CMP-ketodeoxyoctanoate biosynthetic process" RELATED [ISBN:0198506732]
xref: MetaCyc:KDOSYN-PWY
xref: MetaCyc:PWY-1269
xref: MetaCyc:PWY-5111
is_a: GO:0009226 ! nucleotide-sugar biosynthetic process
is_a: GO:0033467 ! CMP-keto-3-deoxy-D-manno-octulosonic acid metabolic process

[Term]
id: GO:0033469
name: gibberellin 12 metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving gibberellin 12, (1R,2S,3S,4R,8S,9S,12R)-4,8-dimethyl-13-methylidenetetracyclo[10.2.1.01,9.03,8]pentadecane-2,4-dicarboxylic acid 1meta,4a-dimethyl-8-methylidene-4aalpha,4bbeta-gibbane-1alpha,10beta-dicarboxylic acid." [CHEBI:30088, GOC:mah]
synonym: "GA12 metabolic process" EXACT []
synonym: "gibberellin 12 metabolism" EXACT []
synonym: "gibberellin A12 metabolic process" EXACT []
is_a: GO:0009685 ! gibberellin metabolic process
is_a: GO:0043648 ! dicarboxylic acid metabolic process

[Term]
id: GO:0033470
name: gibberellin 12 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of gibberellin 12, (1R,2S,3S,4R,8S,9S,12R)-4,8-dimethyl-13-methylidenetetracyclo[10.2.1.01,9.03,8]pentadecane-2,4-dicarboxylic acid 1meta,4a-dimethyl-8-methylidene-4aalpha,4bbeta-gibbane-1alpha,10beta-dicarboxylic acid." [CHEBI:30088, GOC:mah]
synonym: "GA12 biosynthetic process" EXACT []
synonym: "gibberellin 12 anabolism" EXACT []
synonym: "gibberellin 12 biosynthesis" EXACT []
synonym: "gibberellin 12 formation" EXACT []
synonym: "gibberellin 12 synthesis" EXACT []
synonym: "gibberellin A12 biosynthetic process" EXACT []
xref: MetaCyc:PWY-5034
is_a: GO:0009686 ! gibberellin biosynthetic process
is_a: GO:0033469 ! gibberellin 12 metabolic process
is_a: GO:0043650 ! dicarboxylic acid biosynthetic process

[Term]
id: GO:0033471
name: GDP-L-galactose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving GDP-L-galactose, a substance composed of L-galactose in glycosidic linkage with guanosine diphosphate." [GOC:mah]
synonym: "GDP-L-galactose metabolism" EXACT []
is_a: GO:0009225 ! nucleotide-sugar metabolic process

[Term]
id: GO:0033472
name: GDP-L-galactose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of GDP-L-galactose, a substance composed of L-galactose in glycosidic linkage with guanosine diphosphate." [GOC:mah]
synonym: "GDP-L-galactose anabolism" EXACT []
synonym: "GDP-L-galactose biosynthesis" EXACT []
synonym: "GDP-L-galactose formation" EXACT []
synonym: "GDP-L-galactose synthesis" EXACT []
xref: MetaCyc:PWY-5115
is_a: GO:0009226 ! nucleotide-sugar biosynthetic process
is_a: GO:0033471 ! GDP-L-galactose metabolic process

[Term]
id: GO:0033473
name: indoleacetic acid conjugate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any indole-3-acetic acid conjugate, a form of indoleacetic acid covalently bound to another molecule." [GOC:mah]
synonym: "IAA conjugate metabolic process" EXACT []
synonym: "indole acetic acid conjugate metabolic process" EXACT []
synonym: "indole acetic acid conjugate metabolism" EXACT []
synonym: "indoleacetic acid conjugate metabolism" EXACT []
is_a: GO:0009683 ! indoleacetic acid metabolic process

[Term]
id: GO:0033474
name: indoleacetic acid conjugate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an indole-3-acetic acid conjugate, a form of indoleacetic acid covalently bound to another molecule." [GOC:mah]
synonym: "IAA conjugate biosynthetic process" EXACT []
synonym: "indole acetic acid conjugate biosynthesis" EXACT []
synonym: "indole acetic acid conjugate biosynthetic process" EXACT []
synonym: "indoleacetic acid conjugate anabolism" EXACT []
synonym: "indoleacetic acid conjugate biosynthesis" EXACT []
synonym: "indoleacetic acid conjugate formation" EXACT []
synonym: "indoleacetic acid conjugate synthesis" EXACT []
is_a: GO:0009851 ! auxin biosynthetic process
is_a: GO:0033473 ! indoleacetic acid conjugate metabolic process
is_a: GO:0042435 ! indole-containing compound biosynthetic process
is_a: GO:0044711 ! single-organism biosynthetic process

[Term]
id: GO:0033475
name: indoleacetic acid amide conjugate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an indole-3-acetic acid amide conjugate, a form of indoleacetic acid covalently bound to an amino acid or polypeptide through an amide bond." [GOC:mah, MetaCyc:PWY-1782]
synonym: "IAA amide conjugate biosynthetic process" EXACT []
synonym: "indole acetic acid amide conjugate biosynthesis" EXACT []
synonym: "indole acetic acid amide conjugate biosynthetic process" EXACT []
synonym: "indoleacetic acid amide conjugate anabolism" EXACT []
synonym: "indoleacetic acid amide conjugate biosynthesis" EXACT []
synonym: "indoleacetic acid amide conjugate formation" EXACT []
synonym: "indoleacetic acid amide conjugate synthesis" EXACT []
xref: MetaCyc:PWY-1782
is_a: GO:0033474 ! indoleacetic acid conjugate biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process

[Term]
id: GO:0033476
name: indoleacetic acid ester conjugate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an indole-3-acetic acid amide conjugate, a form of indoleacetic acid covalently bound to an a sugar or polyol through an ester bond." [GOC:mah, MetaCyc:PWY-1741]
synonym: "IAA ester conjugate biosynthetic process" EXACT []
synonym: "indole acetic acid ester conjugate biosynthesis" EXACT []
synonym: "indole acetic acid ester conjugate biosynthetic process" EXACT []
synonym: "indoleacetic acid ester conjugate anabolism" EXACT []
synonym: "indoleacetic acid ester conjugate biosynthesis" EXACT []
synonym: "indoleacetic acid ester conjugate formation" EXACT []
synonym: "indoleacetic acid ester conjugate synthesis" EXACT []
xref: MetaCyc:PWY-1741
is_a: GO:0033474 ! indoleacetic acid conjugate biosynthetic process

[Term]
id: GO:0033477
name: S-methylmethionine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving S-methyl-methionine (SMM). SMM can be converted to methionine by donating a methyl group to homocysteine, and concurrent operation of this reaction and that mediated by MMT sets up the SMM cycle." [GOC:mah, PMID:12692340]
synonym: "S-methylmethionine metabolism" EXACT []
is_a: GO:0006575 ! cellular modified amino acid metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process

[Term]
id: GO:0033478
name: UDP-rhamnose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving UDP-L-rhamnose, a substance composed of rhamnose in glycosidic linkage with uridine diphosphate." [GOC:mah, PMID:15134748]
synonym: "UDP-rhamnose metabolism" EXACT []
xref: MetaCyc:PWY-3261
is_a: GO:0006793 ! phosphorus metabolic process
is_a: GO:0009225 ! nucleotide-sugar metabolic process

[Term]
id: GO:0033479
name: UDP-D-galacturonate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving UDP-D-galacturonate, a substance composed of galacturonic acid in glycosidic linkage with uridine diphosphate." [GOC:mah]
synonym: "UDP-D-galacturonate metabolism" EXACT []
is_a: GO:0009225 ! nucleotide-sugar metabolic process

[Term]
id: GO:0033480
name: UDP-D-galacturonate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of UDP-D-galacturonate, a substance composed of galacturonic acid in glycosidic linkage with uridine diphosphate." [GOC:mah]
synonym: "UDP-D-galacturonate anabolism" EXACT []
synonym: "UDP-D-galacturonate biosynthesis" EXACT []
synonym: "UDP-D-galacturonate formation" EXACT []
synonym: "UDP-D-galacturonate synthesis" EXACT []
xref: MetaCyc:PWY-4
is_a: GO:0009226 ! nucleotide-sugar biosynthetic process
is_a: GO:0033479 ! UDP-D-galacturonate metabolic process

[Term]
id: GO:0033481
name: galacturonate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of galacturonate, the anion of galacturonic acid." [GOC:mah]
synonym: "galacturonate anabolism" EXACT []
synonym: "galacturonate biosynthesis" EXACT []
synonym: "galacturonate formation" EXACT []
synonym: "galacturonate synthesis" EXACT []
is_a: GO:0019586 ! galacturonate metabolic process
is_a: GO:0046364 ! monosaccharide biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process

[Term]
id: GO:0033482
name: D-galacturonate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of D-galacturonate, the D-enantiomer of galacturonate, the anion of galacturonic acid." [GOC:jsg, GOC:mah]
synonym: "D-galacturonate anabolism" EXACT []
synonym: "D-galacturonate biosynthesis" EXACT []
synonym: "D-galacturonate formation" EXACT []
synonym: "D-galacturonate synthesis" EXACT []
is_a: GO:0033481 ! galacturonate biosynthetic process
is_a: GO:0046396 ! D-galacturonate metabolic process

[Term]
id: GO:0033483
name: gas homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of an internal steady state of a gas within an organism or cell." [GOC:mah]
is_a: GO:0048878 ! chemical homeostasis

[Term]
id: GO:0033484
name: nitric oxide homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of an internal steady state of nitric oxide within an organism or cell." [GOC:mah]
synonym: "NO homeostasis" EXACT []
is_a: GO:0033483 ! gas homeostasis

[Term]
id: GO:0033485
name: cyanidin 3-O-glucoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cyanidin 3-O-glucoside, a basic anthocyanin responsible for red to magenta coloration of flowers and fruits." [GOC:mah, MetaCyc:PWY-5125]
synonym: "cyanidin 3-O-glucoside anabolism" EXACT []
synonym: "cyanidin 3-O-glucoside biosynthesis" EXACT []
synonym: "cyanidin 3-O-glucoside formation" EXACT []
synonym: "cyanidin 3-O-glucoside synthesis" EXACT []
xref: MetaCyc:PWY-5125
is_a: GO:0009813 ! flavonoid biosynthetic process
is_a: GO:1901038 ! cyanidin 3-O-glucoside metabolic process
is_a: GO:1901806 ! beta-glucoside biosynthetic process

[Term]
id: GO:0033486
name: delphinidin 3-O-glucoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of delphinidin 3-O-glucoside, a basic, water-soluble anthocyanin responsible for blue coloration of flowers and fruits." [GOC:mah, MetaCyc:PWY-5153]
synonym: "delphinidin 3-O-glucoside anabolism" EXACT []
synonym: "delphinidin 3-O-glucoside biosynthesis" EXACT []
synonym: "delphinidin 3-O-glucoside formation" EXACT []
synonym: "delphinidin 3-O-glucoside synthesis" EXACT []
xref: MetaCyc:PWY-5153
is_a: GO:0009813 ! flavonoid biosynthetic process
is_a: GO:1901806 ! beta-glucoside biosynthetic process

[Term]
id: GO:0033487
name: pelargonidin 3-O-glucoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pelargonidin 3-O-glucoside, a basic anthocyanin responsible for red to magenta coloration of flowers and fruits." [GOC:mah, MetaCyc:PWY-5125]
synonym: "pelargonidin 3-O-glucoside anabolism" EXACT []
synonym: "pelargonidin 3-O-glucoside biosynthesis" EXACT []
synonym: "pelargonidin 3-O-glucoside formation" EXACT []
synonym: "pelargonidin 3-O-glucoside synthesis" EXACT []
xref: MetaCyc:PWY-5125
is_a: GO:0009813 ! flavonoid biosynthetic process
is_a: GO:1901806 ! beta-glucoside biosynthetic process

[Term]
id: GO:0033488
name: cholesterol biosynthetic process via 24,25-dihydrolanosterol
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, via the intermediate 24,25-dihydrolanosterol." [GOC:mah, MetaCyc:PWY66-3]
synonym: "cholesterol anabolism via 24,25-dihydrolanosterol" EXACT []
synonym: "cholesterol biosynthesis via 24,25-dihydrolanosterol" EXACT []
synonym: "cholesterol formation via 24,25-dihydrolanosterol" EXACT []
synonym: "cholesterol synthesis via 24,25-dihydrolanosterol" EXACT []
xref: MetaCyc:PWY66-3
is_a: GO:0006695 ! cholesterol biosynthetic process

[Term]
id: GO:0033489
name: cholesterol biosynthetic process via desmosterol
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, via the intermediate desmosterol." [GOC:mah, MetaCyc:PWY66-4]
synonym: "cholesterol anabolism via desmosterol" EXACT []
synonym: "cholesterol biosynthesis via desmosterol" EXACT []
synonym: "cholesterol formation via desmosterol" EXACT []
synonym: "cholesterol synthesis via desmosterol" EXACT []
xref: MetaCyc:PWY66-4
is_a: GO:0006695 ! cholesterol biosynthetic process

[Term]
id: GO:0033490
name: cholesterol biosynthetic process via lathosterol
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, via the intermediate lathosterol." [GOC:mah, MetaCyc:PWY66-341]
synonym: "cholesterol anabolism via lathosterol" EXACT []
synonym: "cholesterol biosynthesis via lathosterol" EXACT []
synonym: "cholesterol formation via lathosterol" EXACT []
synonym: "cholesterol synthesis via lathosterol" EXACT []
xref: MetaCyc:PWY66-341
is_a: GO:0006695 ! cholesterol biosynthetic process

[Term]
id: GO:0033491
name: coniferin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving coniferin, 4-(3-hydroxyprop-1-en-1-yl)-2-methoxyphenyl beta-D-glucopyranoside." [CHEBI:16220, GOC:mah, MetaCyc:PWY-116]
synonym: "coniferin metabolism" EXACT []
xref: MetaCyc:PWY-116
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0018904 ! ether metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901804 ! beta-glucoside metabolic process

[Term]
id: GO:0033492
name: esculetin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving esculetin, 6,7-dihydroxycoumarin." [GOC:mah]
synonym: "esculetin metabolism" EXACT []
is_a: GO:0009804 ! coumarin metabolic process

[Term]
id: GO:0033493
name: esculetin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of esculetin, 6,7-dihydroxycoumarin." [GOC:mah]
synonym: "esculetin anabolism" EXACT []
synonym: "esculetin biosynthesis" EXACT []
synonym: "esculetin formation" EXACT []
synonym: "esculetin synthesis" EXACT []
xref: MetaCyc:PWY-5349
is_a: GO:0009805 ! coumarin biosynthetic process
is_a: GO:0033492 ! esculetin metabolic process

[Term]
id: GO:0033494
name: ferulate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ferulate, (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate." [CHEBI:29749, GOC:mah]
synonym: "ferulate metabolism" EXACT []
is_a: GO:0009698 ! phenylpropanoid metabolic process
is_a: GO:0018904 ! ether metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0033495
name: ferulate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ferulate, (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate." [CHEBI:29749, GOC:mah]
synonym: "ferulate anabolism" EXACT []
synonym: "ferulate biosynthesis" EXACT []
synonym: "ferulate formation" EXACT []
synonym: "ferulate synthesis" EXACT []
xref: MetaCyc:PWY-5168
is_a: GO:0009699 ! phenylpropanoid biosynthetic process
is_a: GO:0033494 ! ferulate metabolic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:1901503 ! ether biosynthetic process

[Term]
id: GO:0033496
name: sinapate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sinapate, (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate." [CHEBI:30023, GOC:mah]
synonym: "sinapate metabolism" EXACT []
is_a: GO:0009698 ! phenylpropanoid metabolic process
is_a: GO:0018904 ! ether metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:0033497
name: sinapate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sinapate, (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate." [CHEBI:30023, GOC:mah]
synonym: "sinapate anabolism" EXACT []
synonym: "sinapate biosynthesis" EXACT []
synonym: "sinapate formation" EXACT []
synonym: "sinapate synthesis" EXACT []
xref: MetaCyc:PWY-5168
is_a: GO:0009699 ! phenylpropanoid biosynthetic process
is_a: GO:0033496 ! sinapate metabolic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:1901503 ! ether biosynthetic process

[Term]
id: GO:0033498
name: galactose catabolic process via D-galactonate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of galactose, via the intermediate D-galactonate." [GOC:mah, MetaCyc:GALDEG-PWY]
subset: gosubset_prok
synonym: "galactose breakdown via D-galactonate" EXACT []
synonym: "galactose catabolism via D-galactonate" EXACT []
synonym: "galactose degradation via D-galactonate" EXACT []
xref: MetaCyc:GALDEG-PWY
is_a: GO:0019388 ! galactose catabolic process

[Term]
id: GO:0033499
name: galactose catabolic process via UDP-galactose
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of galactose, via the intermediate UDP-galactose." [GOC:mah, MetaCyc:PWY-3821]
synonym: "galactose breakdown via UDP-galactose" EXACT []
synonym: "galactose catabolism via UDP-galactose" EXACT []
synonym: "galactose degradation via UDP-galactose" EXACT []
synonym: "Leloir Pathway" RELATED [PMID:14741191]
xref: MetaCyc:PWY-3821
is_a: GO:0019388 ! galactose catabolic process

[Term]
id: GO:0033500
name: carbohydrate homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of an internal steady state of a carbohydrate within an organism or cell." [GOC:mah]
subset: gosubset_prok
is_a: GO:0048878 ! chemical homeostasis

[Term]
id: GO:0033501
name: galactose homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of an internal steady state of galactose within an organism or cell." [GOC:mah]
is_a: GO:0033500 ! carbohydrate homeostasis

[Term]
id: GO:0033502
name: cellular galactose homeostasis
namespace: biological_process
def: "A cellular homeostatic process involved in the maintenance of an internal steady state of galactose within a cell or between a cell and its external environment." [GOC:dph, GOC:mah, GOC:tb]
subset: gosubset_prok
synonym: "cell galactose homeostasis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0033501 ! galactose homeostasis
is_a: GO:0055082 ! cellular chemical homeostasis

[Term]
id: GO:0033503
name: HULC complex
namespace: cellular_component
def: "A ubiquitin-conjugating enzyme complex that contains two RING finger proteins, which have ubiquitin ligase activity, in addition to a protein with ubiquitin-conjugating enzyme activity; catalyzes the ubiquitination of histone H2B at lysine 119 (or the equivalent residue). In Schizosaccharomyces the subunits are Rhp1, Brl2/Rfp1 and Brl1/Rfp2." [GOC:mah, PMID:17363370, PMID:17374714]
is_a: GO:0000151 ! ubiquitin ligase complex
is_a: GO:0031371 ! ubiquitin conjugating enzyme complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000792 ! heterochromatin

[Term]
id: GO:0033504
name: floor plate development
namespace: biological_process
def: "The progression of the floor plate over time from its initial formation until its mature state." [GOC:dh]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021915 ! neural tube development

[Term]
id: GO:0033505
name: floor plate morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the floor plate is generated and organized." [GOC:dh]
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0048729 ! tissue morphogenesis
relationship: part_of GO:0033504 ! floor plate development

[Term]
id: GO:0033506
name: glucosinolate biosynthetic process from homomethionine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glucosinolates from other compounds including homomethionine." [GOC:mah, MetaCyc:PWY-1187]
subset: gosubset_prok
synonym: "glucosinolate anabolism from homomethionine" EXACT []
synonym: "glucosinolate biosynthesis from homomethionine" EXACT []
synonym: "glucosinolate formation from homomethionine" EXACT []
synonym: "glucosinolate synthesis from homomethionine" EXACT []
xref: MetaCyc:PWY-1187
is_a: GO:0019761 ! glucosinolate biosynthetic process
is_a: GO:0033321 ! homomethionine metabolic process

[Term]
id: GO:0033507
name: glucosinolate biosynthetic process from phenylalanine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glucosinolates from other compounds including phenylalanine." [GOC:mah, MetaCyc:PWY-2821]
subset: gosubset_prok
synonym: "glucosinolate anabolism from phenylalanine" EXACT []
synonym: "glucosinolate biosynthesis from phenylalanine" EXACT []
synonym: "glucosinolate formation from phenylalanine" EXACT []
synonym: "glucosinolate synthesis from phenylalanine" EXACT []
xref: MetaCyc:PWY-2821
is_a: GO:0009072 ! aromatic amino acid family metabolic process
is_a: GO:0019761 ! glucosinolate biosynthetic process
is_a: GO:1901605 ! alpha-amino acid metabolic process

[Term]
id: GO:0033508
name: glutamate catabolic process to butyrate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including butyrate." [GOC:mah, MetaCyc:PWY-5087]
subset: gosubset_prok
synonym: "glutamate breakdown to butyrate" EXACT []
synonym: "glutamate degradation to butyrate" EXACT []
xref: MetaCyc:PWY-5087
is_a: GO:0006538 ! glutamate catabolic process
is_a: GO:0019605 ! butyrate metabolic process

[Term]
id: GO:0033509
name: glutamate catabolic process to propionate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including propionate." [GOC:mah, MetaCyc:PWY-5088]
subset: gosubset_prok
synonym: "glutamate breakdown to propionate" EXACT []
synonym: "glutamate degradation to propionate" EXACT []
xref: MetaCyc:PWY-5088
is_a: GO:0006538 ! glutamate catabolic process
is_a: GO:0019541 ! propionate metabolic process

[Term]
id: GO:0033510
name: luteolin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving luteolin, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one." [CHEBI:15864, GOC:mah]
synonym: "luteolin metabolism" EXACT []
is_a: GO:0051552 ! flavone metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process

[Term]
id: GO:0033511
name: luteolin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of luteolin, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one." [CHEBI:15864, GOC:mah]
synonym: "luteolin anabolism" EXACT []
synonym: "luteolin biosynthesis" EXACT []
synonym: "luteolin formation" EXACT []
synonym: "luteolin synthesis" EXACT []
xref: MetaCyc:PWY-5060
is_a: GO:0033510 ! luteolin metabolic process
is_a: GO:0051553 ! flavone biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process

[Term]
id: GO:0033512
name: L-lysine catabolic process to acetyl-CoA via saccharopine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA, via the intermediate saccharopine." [GOC:mah, MetaCyc:LYSINE-DEG1-PWY]
subset: gosubset_prok
synonym: "L-lysine breakdown to acetyl-CoA via saccharopine" EXACT []
synonym: "L-lysine degradation to acetyl-CoA via saccharopine" EXACT []
xref: MetaCyc:LYSINE-DEG1-PWY
is_a: GO:0019474 ! L-lysine catabolic process to acetyl-CoA

[Term]
id: GO:0033513
name: L-lysine catabolic process to acetyl-CoA via 5-aminopentanamide
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA, via the intermediate 5-aminopentanamide." [GOC:mah, MetaCyc:PWY-5280]
subset: gosubset_prok
synonym: "L-lysine breakdown to acetyl-CoA via 5-aminopentanamide" EXACT []
synonym: "L-lysine degradation to acetyl-CoA via 5-aminopentanamide" EXACT []
xref: MetaCyc:PWY-5280
is_a: GO:0019474 ! L-lysine catabolic process to acetyl-CoA

[Term]
id: GO:0033514
name: L-lysine catabolic process to acetyl-CoA via L-pipecolate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA, via the intermediate L-pipecolate." [GOC:mah, MetaCyc:PWY-5283]
subset: gosubset_prok
synonym: "L-lysine breakdown to acetyl-CoA via L-pipecolate" EXACT []
synonym: "L-lysine degradation to acetyl-CoA via L-pipecolate" EXACT []
xref: MetaCyc:PWY-5283
is_a: GO:0019474 ! L-lysine catabolic process to acetyl-CoA

[Term]
id: GO:0033515
name: L-lysine catabolic process using lysine 6-aminotransferase
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including alpha-aminoadipate; in this pathway, L-lysine is converted to 2-aminoadipate-6-semialdehyde by lysine 6-aminotransferase." [GOC:mah, MetaCyc:PWY-5298]
subset: gosubset_prok
synonym: "L-lysine breakdown using lysine 6-aminotransferase" EXACT [GOC:mah]
synonym: "L-lysine degradation using lysine 6-aminotransferase" EXACT [GOC:mah]
xref: MetaCyc:PWY-5298
is_a: GO:0019474 ! L-lysine catabolic process to acetyl-CoA

[Term]
id: GO:0033516
name: L-methionine biosynthetic process from homoserine via O-phospho-L-homoserine and cystathionine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including homoserine, via the intermediates O-phospho-L-homoserine and cystathionine." [GOC:mah, MetaCyc:PWY-702]
subset: gosubset_prok
synonym: "L-methionine anabolism from homoserine via O-phospho-L-homoserine and cystathionine" EXACT [GOC:mah]
synonym: "L-methionine formation from homoserine via O-phospho-L-homoserine and cystathionine" EXACT [GOC:mah]
synonym: "L-methionine synthesis from homoserine via O-phospho-L-homoserine and cystathionine" EXACT [GOC:mah]
synonym: "methionine biosynthetic process from homoserine via O-phospho-L-homoserine and cystathionine" EXACT [GOC:mah]
xref: MetaCyc:PWY-702
is_a: GO:0019279 ! L-methionine biosynthetic process from L-homoserine via cystathionine

[Term]
id: GO:0033517
name: myo-inositol hexakisphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phytic acid, myo-inositol hexakisphosphate, a regulator of intracellular signaling, a highly abundant animal anti-nutrient and a phosphate and mineral storage compound in plant seeds." [CHEBI:17401, PMID:16107538]
synonym: "myo-inositol hexakisphosphate metabolism" EXACT []
synonym: "phytate metabolic process" EXACT []
synonym: "phytate metabolism" EXACT []
is_a: GO:0043647 ! inositol phosphate metabolic process

[Term]
id: GO:0033518
name: myo-inositol hexakisphosphate dephosphorylation
namespace: biological_process
def: "The process of removing one or more phosphate group from myo-inositol hexakisphosphate." [GOC:mah]
synonym: "phytate dephosphorylation" EXACT []
xref: MetaCyc:PWY-4702
xref: MetaCyc:PWY-4781
is_a: GO:0033517 ! myo-inositol hexakisphosphate metabolic process
is_a: GO:0046855 ! inositol phosphate dephosphorylation

[Term]
id: GO:0033519
name: phytyl diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phytyl diphosphate, (2E)-3,7,11,15-tetramethylhexadec-2-en-1-yl trihydrogen diphosphate." [CHEBI:18187, GOC:mah]
synonym: "phytyl diphosphate metabolism" EXACT []
is_a: GO:0006644 ! phospholipid metabolic process
is_a: GO:0006721 ! terpenoid metabolic process

[Term]
id: GO:0033520
name: phytol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phytol, (2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-ol." [CHEBI:17327, GOC:mah]
synonym: "phytol anabolism" EXACT []
synonym: "phytol biosynthesis" EXACT []
synonym: "phytol formation" EXACT []
synonym: "phytol synthesis" EXACT []
is_a: GO:0016102 ! diterpenoid biosynthetic process
is_a: GO:0033306 ! phytol metabolic process
is_a: GO:0034309 ! primary alcohol biosynthetic process
is_a: GO:1903175 ! fatty alcohol biosynthetic process

[Term]
id: GO:0033521
name: phytyl diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phytyl diphosphate, (2E)-3,7,11,15-tetramethylhexadec-2-en-1-yl trihydrogen diphosphate." [CHEBI:18187, GOC:mah]
synonym: "phytyl diphosphate anabolism" EXACT []
synonym: "phytyl diphosphate biosynthesis" EXACT []
synonym: "phytyl diphosphate formation" EXACT []
synonym: "phytyl diphosphate synthesis" EXACT []
xref: MetaCyc:PWY-5063
is_a: GO:0008654 ! phospholipid biosynthetic process
is_a: GO:0016114 ! terpenoid biosynthetic process
is_a: GO:0033519 ! phytyl diphosphate metabolic process

[Term]
id: GO:0033522
name: histone H2A ubiquitination
namespace: biological_process
def: "The modification of histone H2A by addition of one or more ubiquitin groups." [GOC:bf, GOC:mah, PMID:15509584, PMID:16473935, PMID:18430235]
is_a: GO:0016574 ! histone ubiquitination

[Term]
id: GO:0033523
name: histone H2B ubiquitination
namespace: biological_process
def: "The modification of histone H2B by addition of ubiquitin groups." [GOC:mah]
is_a: GO:0016574 ! histone ubiquitination

[Term]
id: GO:0033524
name: sinapate ester metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ester derivatives of sinapate, (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate." [CHEBI:30023, GOC:mah]
synonym: "sinapate ester metabolism" EXACT []
is_a: GO:0009698 ! phenylpropanoid metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process

[Term]
id: GO:0033525
name: sinapate ester biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ester derivates of sinapate, (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate." [CHEBI:30023, GOC:mah]
synonym: "sinapate ester anabolism" EXACT []
synonym: "sinapate ester biosynthesis" EXACT []
synonym: "sinapate ester formation" EXACT []
synonym: "sinapate ester synthesis" EXACT []
xref: MetaCyc:PWY-3301
is_a: GO:0009699 ! phenylpropanoid biosynthetic process
is_a: GO:0033524 ! sinapate ester metabolic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process

[Term]
id: GO:0033526
name: tetrapyrrole biosynthetic process from glutamate
namespace: biological_process
def: "The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next, from other compounds, including L-glutamate." [CHEBI:26932, GOC:mah, MetaCyc:PWY-5188]
synonym: "tetrapyrrole anabolism from glutamate" EXACT []
synonym: "tetrapyrrole biosynthesis from glutamate" EXACT []
synonym: "tetrapyrrole formation from glutamate" EXACT []
synonym: "tetrapyrrole synthesis from glutamate" EXACT []
xref: MetaCyc:PWY-5188
is_a: GO:0006536 ! glutamate metabolic process
is_a: GO:0033014 ! tetrapyrrole biosynthetic process
is_a: GO:0044711 ! single-organism biosynthetic process

[Term]
id: GO:0033527
name: tetrapyrrole biosynthetic process from glycine and succinyl-CoA
namespace: biological_process
def: "The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next, from other compounds, including glycine and succinyl-CoA." [CHEBI:26932, GOC:mah, MetaCyc:PWY-5189]
synonym: "tetrapyrrole anabolism from glycine and succinyl-CoA" EXACT []
synonym: "tetrapyrrole biosynthesis from glycine and succinyl-CoA" EXACT []
synonym: "tetrapyrrole formation from glycine and succinyl-CoA" EXACT []
synonym: "tetrapyrrole synthesis from glycine and succinyl-CoA" EXACT []
xref: MetaCyc:PWY-5189
is_a: GO:0006104 ! succinyl-CoA metabolic process
is_a: GO:0006544 ! glycine metabolic process
is_a: GO:0033014 ! tetrapyrrole biosynthetic process
is_a: GO:0044711 ! single-organism biosynthetic process

[Term]
id: GO:0033528
name: S-methylmethionine cycle
namespace: biological_process
def: "A cyclic series of interconversions involving S-methyl-L-methionine, S-adenosyl-L-homocysteine, S-adenosyl-L-methionine, L-homocysteine, and L-methionine. Converts the methionine group of adenosylmethionine back to free methionine, and may serve regulate the cellular adenosylmethionine level." [GOC:mah, MetaCyc:PWY-5441]
xref: MetaCyc:PWY-5441
is_a: GO:0033477 ! S-methylmethionine metabolic process

[Term]
id: GO:0033529
name: raffinose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of raffinose, the trisaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [CHEBI:16634, GOC:mah]
synonym: "raffinose anabolism" EXACT []
synonym: "raffinose biosynthesis" EXACT []
synonym: "raffinose formation" EXACT []
synonym: "raffinose synthesis" EXACT []
is_a: GO:0010325 ! raffinose family oligosaccharide biosynthetic process
is_a: GO:0033530 ! raffinose metabolic process

[Term]
id: GO:0033530
name: raffinose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving raffinose, the trisaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [CHEBI:16634, GOC:mah]
synonym: "raffinose metabolism" EXACT []
is_a: GO:0009311 ! oligosaccharide metabolic process

[Term]
id: GO:0033531
name: stachyose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving stachyose, the tetrasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [CHEBI:17164, GOC:mah]
synonym: "stachyose metabolism" EXACT []
is_a: GO:0009311 ! oligosaccharide metabolic process

[Term]
id: GO:0033532
name: stachyose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of stachyose, the tetrasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [CHEBI:17164, GOC:mah]
synonym: "stachyose anabolism" EXACT []
synonym: "stachyose biosynthesis" EXACT []
synonym: "stachyose formation" EXACT []
synonym: "stachyose synthesis" EXACT []
xref: MetaCyc:PWY-5337
is_a: GO:0010325 ! raffinose family oligosaccharide biosynthetic process
is_a: GO:0033531 ! stachyose metabolic process

[Term]
id: GO:0033533
name: verbascose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving verbascose, the pentasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [GOC:mah, MetaCyc:CPD-8065]
synonym: "verbascose metabolism" EXACT []
is_a: GO:0009311 ! oligosaccharide metabolic process

[Term]
id: GO:0033534
name: verbascose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of verbascose, the pentasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [GOC:mah, MetaCyc:CPD-8065]
synonym: "verbascose anabolism" EXACT []
synonym: "verbascose biosynthesis" EXACT []
synonym: "verbascose formation" EXACT []
synonym: "verbascose synthesis" EXACT []
is_a: GO:0010325 ! raffinose family oligosaccharide biosynthetic process
is_a: GO:0033533 ! verbascose metabolic process

[Term]
id: GO:0033535
name: ajugose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ajugose, the hexasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [GOC:mah, MetaCyc:CPD-8066]
synonym: "ajugose metabolism" EXACT []
is_a: GO:0009311 ! oligosaccharide metabolic process

[Term]
id: GO:0033536
name: ajugose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ajugose, the hexasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [GOC:mah, MetaCyc:CPD-8066]
synonym: "ajugose anabolism" EXACT []
synonym: "ajugose biosynthesis" EXACT []
synonym: "ajugose formation" EXACT []
synonym: "ajugose synthesis" EXACT []
is_a: GO:0010325 ! raffinose family oligosaccharide biosynthetic process
is_a: GO:0033535 ! ajugose metabolic process

[Term]
id: GO:0033537
name: ajugose biosynthetic process using galactinol:raffinose galactosyltransferase
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ajugose, the hexasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside, by a pathway in which galactinol:raffinose galactosyltransferase catalyzes chain elongation by transferring the alpha-galactosyl residue of galactinol to the oligosaccharide." [GOC:mah, MetaCyc:PWY-5342]
synonym: "ajugose anabolism using galactinol:raffinose galactosyltransferase" EXACT []
synonym: "ajugose biosynthesis using galactinol:raffinose galactosyltransferase" EXACT []
synonym: "ajugose formation using galactinol:raffinose galactosyltransferase" EXACT []
synonym: "ajugose synthesis using galactinol:raffinose galactosyltransferase" EXACT []
xref: MetaCyc:PWY-5342
is_a: GO:0033536 ! ajugose biosynthetic process

[Term]
id: GO:0033538
name: ajugose biosynthetic process using galactan:galactan galactosyltransferase
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ajugose, the hexasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside, by a pathway in which galactan:galactan galactosyltransferase catalyzes chain elongation by transferring the alpha-galactosyl residue of one raffinose-family oligosaccharide to another." [GOC:mah, MetaCyc:PWY-5343]
synonym: "ajugose anabolism using galactan:galactan galactosyltransferase" EXACT []
synonym: "ajugose biosynthesis using galactan:galactan galactosyltransferase" EXACT []
synonym: "ajugose formation using galactan:galactan galactosyltransferase" EXACT []
synonym: "ajugose synthesis using galactan:galactan galactosyltransferase" EXACT []
xref: MetaCyc:PWY-5343
is_a: GO:0033536 ! ajugose biosynthetic process

[Term]
id: GO:0033539
name: fatty acid beta-oxidation using acyl-CoA dehydrogenase
namespace: biological_process
def: "A fatty acid beta-oxidation pathway in which the initial step of each oxidation cycle, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA dehydrogenase; the electrons removed by oxidation pass through the respiratory chain to oxygen and leave H2O as the product. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, MetaCyc:FAO-PWY, MetaCyc:PWY-5136]
xref: MetaCyc:FAO-PWY
is_a: GO:0006635 ! fatty acid beta-oxidation
relationship: has_part GO:0003995 ! acyl-CoA dehydrogenase activity

[Term]
id: GO:0033540
name: fatty acid beta-oxidation using acyl-CoA oxidase
namespace: biological_process
def: "A fatty acid beta-oxidation pathway in which the initial step, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, MetaCyc:PWY-5136]
xref: MetaCyc:PWY-5136
xref: Reactome:REACT_101106 "Beta-oxidation of very long chain fatty acids, Sus scrofa"
xref: Reactome:REACT_101952 "Beta-oxidation of very long chain fatty acids, Arabidopsis thaliana"
xref: Reactome:REACT_102511 "Beta-oxidation of very long chain fatty acids, Oryza sativa"
xref: Reactome:REACT_104085 "Beta-oxidation of very long chain fatty acids, Rattus norvegicus"
xref: Reactome:REACT_104857 "Beta-oxidation of pristanoyl-CoA, Taeniopygia guttata"
xref: Reactome:REACT_107900 "Beta-oxidation of very long chain fatty acids, Dictyostelium discoideum"
xref: Reactome:REACT_110355 "Beta-oxidation of very long chain fatty acids, Drosophila melanogaster"
xref: Reactome:REACT_17017 "Beta-oxidation of pristanoyl-CoA, Homo sapiens"
xref: Reactome:REACT_17062 "Beta-oxidation of very long chain fatty acids, Homo sapiens"
xref: Reactome:REACT_29971 "Beta-oxidation of very long chain fatty acids, Xenopus tropicalis"
xref: Reactome:REACT_30695 "Beta-oxidation of very long chain fatty acids, Escherichia coli"
xref: Reactome:REACT_31512 "Beta-oxidation of pristanoyl-CoA, Arabidopsis thaliana"
xref: Reactome:REACT_33484 "Beta-oxidation of pristanoyl-CoA, Danio rerio"
xref: Reactome:REACT_33669 "Beta-oxidation of pristanoyl-CoA, Escherichia coli"
xref: Reactome:REACT_34044 "Beta-oxidation of pristanoyl-CoA, Canis familiaris"
xref: Reactome:REACT_77016 "Beta-oxidation of very long chain fatty acids, Gallus gallus"
xref: Reactome:REACT_78435 "Beta-oxidation of pristanoyl-CoA, Sus scrofa"
xref: Reactome:REACT_78524 "Beta-oxidation of pristanoyl-CoA, Caenorhabditis elegans"
xref: Reactome:REACT_79245 "Beta-oxidation of very long chain fatty acids, Danio rerio"
xref: Reactome:REACT_81137 "Beta-oxidation of pristanoyl-CoA, Xenopus tropicalis"
xref: Reactome:REACT_81180 "Beta-oxidation of pristanoyl-CoA, Oryza sativa"
xref: Reactome:REACT_82278 "Beta-oxidation of pristanoyl-CoA, Bos taurus"
xref: Reactome:REACT_83684 "Beta-oxidation of pristanoyl-CoA, Saccharomyces cerevisiae"
xref: Reactome:REACT_83937 "Beta-oxidation of pristanoyl-CoA, Rattus norvegicus"
xref: Reactome:REACT_84654 "Beta-oxidation of very long chain fatty acids, Caenorhabditis elegans"
xref: Reactome:REACT_85187 "Beta-oxidation of very long chain fatty acids, Mycobacterium tuberculosis"
xref: Reactome:REACT_85427 "Beta-oxidation of pristanoyl-CoA, Drosophila melanogaster"
xref: Reactome:REACT_85716 "Beta-oxidation of pristanoyl-CoA, Mycobacterium tuberculosis"
xref: Reactome:REACT_86200 "Beta-oxidation of very long chain fatty acids, Saccharomyces cerevisiae"
xref: Reactome:REACT_90451 "Beta-oxidation of pristanoyl-CoA, Dictyostelium discoideum"
xref: Reactome:REACT_92360 "Beta-oxidation of pristanoyl-CoA, Gallus gallus"
xref: Reactome:REACT_92459 "Beta-oxidation of very long chain fatty acids, Staphylococcus aureus N315"
xref: Reactome:REACT_95073 "Beta-oxidation of pristanoyl-CoA, Mus musculus"
xref: Reactome:REACT_95357 "Beta-oxidation of very long chain fatty acids, Taeniopygia guttata"
xref: Reactome:REACT_96610 "Beta-oxidation of very long chain fatty acids, Mus musculus"
xref: Reactome:REACT_96713 "Beta-oxidation of very long chain fatty acids, Bos taurus"
xref: Reactome:REACT_99031 "Beta-oxidation of very long chain fatty acids, Canis familiaris"
is_a: GO:0006635 ! fatty acid beta-oxidation

[Term]
id: GO:0033541
name: fatty acid beta-oxidation, unsaturated, odd number
namespace: biological_process
def: "A fatty acid beta-oxidation pathway by which fatty acids having cis-double bonds on odd-numbered carbons are degraded. In this pathway, a cis-3-enoyl-CoA is generated by the core beta-oxidation pathway, and then converted to a trans-2-enoyl-CoA, which can return to the core beta-oxidation pathway for complete degradation. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, MetaCyc:PWY-5137]
xref: MetaCyc:PWY-5137
is_a: GO:0006635 ! fatty acid beta-oxidation

[Term]
id: GO:0033542
name: fatty acid beta-oxidation, unsaturated, even number
namespace: biological_process
def: "A fatty acid beta-oxidation pathway by which fatty acids having cis-double bonds on even-numbered carbons are degraded. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, MetaCyc:PWY-5138]
xref: MetaCyc:PWY-5138
is_a: GO:0006635 ! fatty acid beta-oxidation

[Term]
id: GO:0033543
name: fatty acid beta-oxidation, unsaturated, even number, reductase/isomerase pathway
namespace: biological_process
def: "A fatty acid beta-oxidation pathway by which fatty acids having cis-double bonds on even-numbered carbons are degraded. In this pathway, the intermediate 2,4-dienoyl-CoA is converted to trans-2-enoyl-CoA by 2,4-dienoyl-CoA reductase and delta3-delta2-enoyl-CoA isomerase; trans-2-enoyl-CoA returns to the core beta-oxidation pathway for further degradation. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, MetaCyc:PWY-5138]
is_a: GO:0033542 ! fatty acid beta-oxidation, unsaturated, even number

[Term]
id: GO:0033544
name: fatty acid beta-oxidation, unsaturated, even number, epimerase pathway
namespace: biological_process
def: "A fatty acid beta-oxidation pathway by which fatty acids having cis-double bonds on even-numbered carbons are degraded. In this pathway, the intermediate 2,4-dienoyl-CoA is converted to cis-2-enoyl-CoA through one more cycle of the core beta-oxidation pathway. Cis-2-enoyl-CoA cannot be completely degraded via the core beta-oxidation pathway because hydratation of cis-2-enoyl-CoA yields D-3-hydroxyacyl-CoA, which is not a substrate for 3-hydroxylacyl-CoA dehydrogenase. Cis-2-enoyl-CoA must enter the so-called epimerase pathway, which involves converting D-3-hydroxyacyl-CoA to L-3-hydroxyacyl-CoA by 3-hydroxylacyl-CoA epimerase or by two stereo-specific enoyl-CoA hydratases. L-3-hydroxyacyl-CoA then returns to the core beta-oxidation pathway. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, MetaCyc:PWY-5138]
is_a: GO:0033542 ! fatty acid beta-oxidation, unsaturated, even number

[Term]
id: GO:0033545
name: myo-inositol hexakisphosphate biosynthetic process, lipid-dependent
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate, phytate, by a pathway using inositol 1,4,5-trisphosphate produced from phosphatidylinositol 4,5-biphosphate hydrolysis by phospholipase C." [GOC:mah, MetaCyc:PWY-6555]
synonym: "myo-inositol hexakisphosphate anabolism, lipid-dependent" EXACT []
synonym: "myo-inositol hexakisphosphate biosynthesis, lipid-dependent" EXACT []
synonym: "myo-inositol hexakisphosphate formation, lipid-dependent" EXACT []
synonym: "myo-inositol hexakisphosphate synthesis, lipid-dependent" EXACT []
synonym: "phytate biosynthesis, lipid-dependent" EXACT []
synonym: "phytate biosynthetic process, lipid-dependent" EXACT []
xref: MetaCyc:PWY-6555
is_a: GO:0010264 ! myo-inositol hexakisphosphate biosynthetic process

[Term]
id: GO:0033546
name: myo-inositol hexakisphosphate biosynthetic process, via inositol 1,3,4-trisphosphate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate, phytate, by a pathway using inositol 1,4,5-trisphosphate produced from phosphatidylinositol 4,5-biphosphate hydrolysis by phospholipase C; in this pathway, inositol 1,4,5-trisphosphate is first converted to inositol 1,3,4-trisphosphate, and then phosphorylated further." [GOC:mah, MetaCyc:PWY-6554]
synonym: "myo-inositol hexakisphosphate anabolism, via inositol 1,3,4-trisphosphate" EXACT []
synonym: "myo-inositol hexakisphosphate biosynthesis, via inositol 1,3,4-trisphosphate" EXACT []
synonym: "myo-inositol hexakisphosphate formation, via inositol 1,3,4-trisphosphate" EXACT []
synonym: "myo-inositol hexakisphosphate synthesis, via inositol 1,3,4-trisphosphate" EXACT []
synonym: "phytate biosynthesis, via inositol 1,3,4-trisphosphate" EXACT []
synonym: "phytate biosynthetic process, via inositol 1,3,4-trisphosphate" EXACT []
xref: MetaCyc:PWY-6554
is_a: GO:0033545 ! myo-inositol hexakisphosphate biosynthetic process, lipid-dependent

[Term]
id: GO:0033547
name: obsolete myo-inositol hexakisphosphate biosynthetic process, via direct phosphorylation of inositol 1,4,5-trisphosphate
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 1D myo-inositol 1,2,3,4,5,6-hexakisphosphate, phytate, by a pathway using inositol 1,4,5-trisphosphate produced from phosphatidylinositol 4,5-biphosphate hydrolysis by phospholipase C; in this pathway, inositol 1,4,5-trisphosphate is successively phosphorylated to yield inositol hexakisphosphate." [GOC:mah, MetaCyc:PWY-4541]
comment: This term was made obsolete because its only cross-reference points to a MetaCyc entry (PWY-4541) that was deleted from the MetaCyc database.
synonym: "myo-inositol hexakisphosphate anabolism, via direct phosphorylation of inositol 1,4,5-trisphosphate" EXACT []
synonym: "myo-inositol hexakisphosphate biosynthesis, via direct phosphorylation of inositol 1,4,5-trisphosphate" EXACT []
synonym: "myo-inositol hexakisphosphate biosynthetic process, via direct phosphorylation of inositol 1,4,5-trisphosphate" EXACT []
synonym: "myo-inositol hexakisphosphate formation, via direct phosphorylation of inositol 1,4,5-trisphosphate" EXACT []
synonym: "myo-inositol hexakisphosphate synthesis, via direct phosphorylation of inositol 1,4,5-trisphosphate" EXACT []
synonym: "phytate biosynthesis, via direct phosphorylation of inositol 1,4,5-trisphosphate" EXACT []
synonym: "phytate biosynthetic process, via direct phosphorylation of inositol 1,4,5-trisphosphate" EXACT []
xref: MetaCyc:PWY-4541
is_obsolete: true

[Term]
id: GO:0033548
name: myo-inositol hexakisphosphate biosynthetic process, lipid-independent
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phytic acid, myo-inositol hexakisphosphate, by the successively phosphorylation of myo-inositol or an inositol trisphosphate; the inositol trisphosphates that may be used by this pathway are inositol 3,4,5-trisphosphate and inositol 3,4,6trisphosphate." [GOC:mah, MetaCyc:PWY-4661]
synonym: "myo-inositol hexakisphosphate anabolism, lipid-independent" EXACT []
synonym: "myo-inositol hexakisphosphate biosynthesis, lipid-independent" EXACT []
synonym: "myo-inositol hexakisphosphate formation, lipid-independent" EXACT []
synonym: "myo-inositol hexakisphosphate synthesis, lipid-independent" EXACT []
synonym: "phytate biosynthesis, lipid-independent" EXACT []
synonym: "phytate biosynthetic process, lipid-independent" EXACT []
xref: MetaCyc:PWY-4661
is_a: GO:0010264 ! myo-inositol hexakisphosphate biosynthetic process

[Term]
id: GO:0033549
name: MAP kinase phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate." [GOC:mah, PMID:12184814, PMID:17208316]
synonym: "MAPK phosphatase activity" EXACT [PMID:12184814]
is_a: GO:0004721 ! phosphoprotein phosphatase activity
relationship: part_of GO:0000188 ! inactivation of MAPK activity

[Term]
id: GO:0033550
name: MAP kinase tyrosine phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: MAP kinase tyrosine phosphate + H2O = MAP kinase tyrosine + phosphate." [GOC:mah]
synonym: "tyrosine-specific MAP kinase phosphatase activity" EXACT []
is_a: GO:0004725 ! protein tyrosine phosphatase activity
is_a: GO:0033549 ! MAP kinase phosphatase activity
relationship: part_of GO:1990264 ! peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity

[Term]
id: GO:0033551
name: monopolin complex
namespace: cellular_component
def: "A protein complex required for clamping microtubule binding sites, ensuring orientation of sister kinetochores to the same pole (mono-orientation) during meiosis I. In the yeast S. cerevisiae this complex consists of Csm1p, Lrs4p, Hrr25p and Mam1p; in S. pombe Psc1 and Mde4 have been identified as subunits." [GOC:mah, GOC:rb, PMID:17627824]
synonym: "monopolin subcomplex Csm1/Lrs4" NARROW []
synonym: "Pcs1/Mde4 complex" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000777 ! condensed chromosome kinetochore

[Term]
id: GO:0033552
name: response to vitamin B3
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B3 stimulus." [GOC:sl]
synonym: "response to niacin" NARROW []
synonym: "response to nicotinamide" NARROW []
is_a: GO:0033273 ! response to vitamin

[Term]
id: GO:0033553
name: rDNA heterochromatin
namespace: cellular_component
def: "A region of heterochromatin located at the rDNA repeats in a chromosome." [GOC:mah]
synonym: "ribosomal DNA heterochromatin" EXACT []
is_a: GO:0000792 ! heterochromatin

[Term]
id: GO:0033554
name: cellular response to stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
is_a: GO:0006950 ! response to stress
is_a: GO:0051716 ! cellular response to stimulus

[Term]
id: GO:0033555
name: multicellular organismal response to stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a multicellular organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
is_a: GO:0006950 ! response to stress
is_a: GO:0044707 ! single-multicellular organism process

[Term]
id: GO:0033556
name: dolichyl pyrophosphate Man7GlcNAc2 alpha-1,3-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the addition of a glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Man(7)GlcNAc(2)-PP-Dol." [GOC:mah, PMID:10336995]
synonym: "dolichyl-P-Glc:Man7GlcNAc2-PP-dolichyl glucosyltransferase activity" EXACT []
xref: EC:2.4.1.-
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0033557
name: Slx1-Slx4 complex
namespace: cellular_component
def: "A heterodimeric protein complex that possesses an endonuclease activity that specifically cleaves certain types of branched DNA structures; because such structures often form during the replication ribosomal DNA (rDNA) repeats, the complex plays a role in the maintenance of rDNA. The subunits are known as Slx1 and Slx 4 in budding and fission yeasts, and are conserved in eukaryotes." [PMID:14528010, PMID:16467377]
is_a: GO:0043234 ! protein complex
is_a: GO:0044454 ! nuclear chromosome part

[Term]
id: GO:0033558
name: protein deacetylase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of an acetyl group or groups from a protein substrate." [GOC:mah]
is_a: GO:0019213 ! deacetylase activity
relationship: part_of GO:0006476 ! protein deacetylation

[Term]
id: GO:0033559
name: unsaturated fatty acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms." [GOC:mah]
subset: gosubset_prok
synonym: "unsaturated fatty acid metabolism" EXACT []
xref: MetaCyc:PWY-762
xref: MetaCyc:PWY-782
is_a: GO:0006631 ! fatty acid metabolic process

[Term]
id: GO:0033560
name: folate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7,8-dihydrofolate + NADP+ = folate + NADPH + H+." [GOC:pde]
subset: gosubset_prok
xref: Reactome:REACT_100229 "Folate is reduced to dihydrofolate (DHF), Gallus gallus"
xref: Reactome:REACT_101075 "DHF is reduced to tetrahydrofolate (THF), Taeniopygia guttata"
xref: Reactome:REACT_101130 "DHF is reduced to tetrahydrofolate (THF), Canis familiaris"
xref: Reactome:REACT_101878 "Folate is reduced to dihydrofolate (DHF), Rattus norvegicus"
xref: Reactome:REACT_102068 "DHF is reduced to tetrahydrofolate (THF), Mus musculus"
xref: Reactome:REACT_104647 "Folate is reduced to dihydrofolate (DHF), Caenorhabditis elegans"
xref: Reactome:REACT_104901 "Folate is reduced to dihydrofolate (DHF), Drosophila melanogaster"
xref: Reactome:REACT_105493 "DHF is reduced to tetrahydrofolate (THF), Drosophila melanogaster"
xref: Reactome:REACT_105841 "DHF is reduced to tetrahydrofolate (THF), Danio rerio"
xref: Reactome:REACT_105897 "DHF is reduced to tetrahydrofolate (THF), Saccharomyces cerevisiae"
xref: Reactome:REACT_108795 "Folate is reduced to dihydrofolate (DHF), Taeniopygia guttata"
xref: Reactome:REACT_109109 "Folate is reduced to dihydrofolate (DHF), Xenopus tropicalis"
xref: Reactome:REACT_11170 "DHF is reduced to tetrahydrofolate (THF), Homo sapiens"
xref: Reactome:REACT_112030 "Folate is reduced to dihydrofolate (DHF), Staphylococcus aureus N315"
xref: Reactome:REACT_11204 "Folate is reduced to dihydrofolate (DHF), Homo sapiens"
xref: Reactome:REACT_112218 "DHF is reduced to tetrahydrofolate (THF), Staphylococcus aureus N315"
xref: Reactome:REACT_114217 "Folate is reduced to dihydrofolate (DHF), Dictyostelium discoideum"
xref: Reactome:REACT_114371 "Folate is reduced to dihydrofolate (DHF), Escherichia coli"
xref: Reactome:REACT_114850 "DHF is reduced to tetrahydrofolate (THF), Escherichia coli"
xref: Reactome:REACT_115392 "DHF is reduced to tetrahydrofolate (THF), Dictyostelium discoideum"
xref: Reactome:REACT_34049 "DHF is reduced to tetrahydrofolate (THF), Sus scrofa"
xref: Reactome:REACT_77158 "DHF is reduced to tetrahydrofolate (THF), Bos taurus"
xref: Reactome:REACT_77749 "Folate is reduced to dihydrofolate (DHF), Canis familiaris"
xref: Reactome:REACT_78748 "Folate is reduced to dihydrofolate (DHF), Saccharomyces cerevisiae"
xref: Reactome:REACT_82785 "Folate is reduced to dihydrofolate (DHF), Mus musculus"
xref: Reactome:REACT_85130 "DHF is reduced to tetrahydrofolate (THF), Rattus norvegicus"
xref: Reactome:REACT_86703 "DHF is reduced to tetrahydrofolate (THF), Caenorhabditis elegans"
xref: Reactome:REACT_87727 "DHF is reduced to tetrahydrofolate (THF), Xenopus tropicalis"
xref: Reactome:REACT_87988 "Folate is reduced to dihydrofolate (DHF), Bos taurus"
xref: Reactome:REACT_88957 "DHF is reduced to tetrahydrofolate (THF), Gallus gallus"
xref: Reactome:REACT_96207 "Folate is reduced to dihydrofolate (DHF), Danio rerio"
xref: Reactome:REACT_98718 "Folate is reduced to dihydrofolate (DHF), Sus scrofa"
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033561
name: regulation of water loss via skin
namespace: biological_process
def: "A process that modulates the rate or extent of water loss from an organism via the skin." [GOC:mah]
synonym: "skin barrier function" RELATED []
is_a: GO:0050891 ! multicellular organismal water homeostasis

[Term]
id: GO:0033562
name: co-transcriptional gene silencing by RNA interference machinery
namespace: biological_process
def: "A process in which the RNAi machinery mediates the degradation of nascent transcripts in association with chromatin." [GOC:mah, GOC:vw, PMID:17512405, PMID:21151114, PMID:22431512]
synonym: "co-transcriptional gene silencing by small RNA" EXACT [GOC:vw]
synonym: "cotranscriptional gene silencing by RNA interference machinery" RELATED []
synonym: "cotranscriptional gene silencing by small RNA" RELATED []
synonym: "RNAi-mediated CTGS" EXACT [GOC:vw]
synonym: "small RNA-mediated cotranscriptional gene silencing" EXACT [GOC:dph, GOC:tb]
is_a: GO:0031047 ! gene silencing by RNA

[Term]
id: GO:0033563
name: dorsal/ventral axon guidance
namespace: biological_process
def: "The process in which the migration of an axon growth cone is directed to a specific target site along the dorsal-ventral body axis in response to a combination of attractive and repulsive cues. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:kmv, GOC:tb]
synonym: "dorsal-ventral axon guidance" EXACT [GOC:mah]
synonym: "dorsal/ventral axon pathfinding" EXACT [GOC:mah]
synonym: "dorsoventral axon guidance" EXACT [GOC:mah]
is_a: GO:0007411 ! axon guidance

[Term]
id: GO:0033564
name: anterior/posterior axon guidance
namespace: biological_process
def: "The process in which the migration of an axon growth cone is directed to a specific target site along the anterior-posterior body axis in response to a combination of attractive and repulsive cues. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:kmv, GOC:tb]
synonym: "anterior-posterior axon guidance" EXACT []
synonym: "anterior/posterior axon pathfinding" EXACT [GOC:mah]
is_a: GO:0007411 ! axon guidance

[Term]
id: GO:0033565
name: ESCRT-0 complex
namespace: cellular_component
def: "A protein complex required for the recycling of Golgi proteins, formation of lumenal membranes and sorting of ubiquitinated proteins into those membranes. This complex includes Vps1p and Hse1p in yeast and the Hrs and STAM proteins in mammals." [GOC:rb, PMID:12055639, PMID:17543868]
synonym: "Hrs/STAM complex" EXACT []
synonym: "Vps27p-Hse1p complex" EXACT []
is_a: GO:0036452 ! ESCRT complex

[Term]
id: GO:0033566
name: gamma-tubulin complex localization
namespace: biological_process
def: "Any process in which a gamma-tubulin complex is transported to, or maintained in, a specific location." [GOC:mah]
synonym: "establishment and maintenance of gamma-tubulin complex localization" EXACT []
synonym: "gamma-tubulin complex localisation" EXACT [GOC:mah]
is_a: GO:0034629 ! cellular protein complex localization

[Term]
id: GO:0033567
name: DNA replication, Okazaki fragment processing
namespace: biological_process
def: "The DNA metabolic process, occurring during lagging strand synthesis, by which RNA primers are removed from Okazaki fragments, the resulting gaps filled by DNA polymerization, and the ends ligated to form a continuous strand." [GOC:mah, ISBN:0716720094]
is_a: GO:0006259 ! DNA metabolic process
relationship: part_of GO:0006273 ! lagging strand elongation

[Term]
id: GO:0033568
name: lactoferrin receptor activity
namespace: molecular_function
def: "Combining with lactoferrin and delivering lactoferrin into the cell via endocytosis. Lactoferrin is an iron-binding glycoprotein which binds ferric iron most efficiently at low pH." [GOC:bf, GOC:mlg, PMID:16261254]
is_a: GO:0038024 ! cargo receptor activity

[Term]
id: GO:0033569
name: lactoferrin transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of lactoferrin from one side of a membrane to the other." [GOC:mlg]
is_a: GO:0015091 ! ferric iron transmembrane transporter activity
is_a: GO:0015450 ! P-P-bond-hydrolysis-driven protein transmembrane transporter activity
relationship: part_of GO:0033571 ! lactoferrin transport

[Term]
id: GO:0033570
name: transferrin transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of transferrin from one side of a membrane to the other." [GOC:mlg]
is_a: GO:0015091 ! ferric iron transmembrane transporter activity
is_a: GO:0015450 ! P-P-bond-hydrolysis-driven protein transmembrane transporter activity
relationship: part_of GO:0033572 ! transferrin transport

[Term]
id: GO:0033571
name: lactoferrin transport
namespace: biological_process
def: "The directed movement of lactoferrin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mlg]
is_a: GO:0015031 ! protein transport
is_a: GO:0015682 ! ferric iron transport

[Term]
id: GO:0033572
name: transferrin transport
namespace: biological_process
def: "The directed movement of transferrin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mlg]
synonym: "melanotransferrin transport" EXACT [PR:000001887]
xref: Reactome:REACT_25283 "Transferrin endocytosis and recycling, Homo sapiens"
is_a: GO:0015031 ! protein transport
is_a: GO:0015682 ! ferric iron transport

[Term]
id: GO:0033573
name: high-affinity iron permease complex
namespace: cellular_component
def: "A protein complex composed of a multicopper ferroxidase that oxidizes Fe(II) to Fe(III), and a ferric iron permease that transports the produced Fe(III) into the cell. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:jp, PMID:16522632, PMID:8599111]
synonym: "high affinity iron permease complex" EXACT []
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0033574
name: response to testosterone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus." [GOC:sl]
synonym: "response to testosterone stimulus" EXACT [GOC:dos]
is_a: GO:0048545 ! response to steroid hormone
is_a: GO:0097305 ! response to alcohol
is_a: GO:1901654 ! response to ketone

[Term]
id: GO:0033575
name: protein glycosylation at cell surface
namespace: biological_process
def: "The addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid at the surface of a cell." [GOC:mah, GOC:pr, PMID:12042244]
synonym: "protein amino acid glycosylation at cell surface" EXACT [GOC:bf]
is_a: GO:0006486 ! protein glycosylation

[Term]
id: GO:0033576
name: protein glycosylation in cytosol
namespace: biological_process
def: "The addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in the cytosol." [GOC:mah, GOC:pr, PMID:12042244]
synonym: "protein amino acid glycosylation in cytosol" EXACT [GOC:bf]
is_a: GO:0006486 ! protein glycosylation
intersection_of: GO:0006486 ! protein glycosylation
intersection_of: occurs_in GO:0005829 ! cytosol
relationship: occurs_in GO:0005829 ! cytosol

[Term]
id: GO:0033577
name: protein glycosylation in endoplasmic reticulum
namespace: biological_process
def: "The addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in the endoplasmic reticulum." [GOC:mah, GOC:pr, PMID:12042244]
synonym: "core glycosylation" RELATED [PMID:6345657]
synonym: "protein amino acid glycosylation in endoplasmic reticulum" EXACT [GOC:bf]
synonym: "protein amino acid glycosylation in ER" EXACT []
is_a: GO:0006486 ! protein glycosylation
intersection_of: GO:0006486 ! protein glycosylation
intersection_of: occurs_in GO:0005783 ! endoplasmic reticulum
relationship: occurs_in GO:0005783 ! endoplasmic reticulum

[Term]
id: GO:0033578
name: protein glycosylation in Golgi
namespace: biological_process
def: "The addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in any compartment of the Golgi apparatus." [GOC:mah, GOC:pr, PMID:12042244]
synonym: "protein amino acid glycosylation in Golgi" EXACT [GOC:bf]
synonym: "terminal glycosylation" NARROW [PMID:6345657]
is_a: GO:0006486 ! protein glycosylation
intersection_of: GO:0006486 ! protein glycosylation
intersection_of: occurs_in GO:0005794 ! Golgi apparatus
relationship: occurs_in GO:0005794 ! Golgi apparatus

[Term]
id: GO:0033579
name: protein galactosylation in endoplasmic reticulum
namespace: biological_process
def: "The addition of a galactose unit to a protein amino acid in the endoplasmic reticulum." [GOC:mah]
synonym: "protein amino acid galactosylation in endoplasmic reticulum" EXACT [GOC:bf]
synonym: "protein amino acid galactosylation in ER" EXACT []
is_a: GO:0033577 ! protein glycosylation in endoplasmic reticulum
is_a: GO:0042125 ! protein galactosylation
intersection_of: GO:0042125 ! protein galactosylation
intersection_of: occurs_in GO:0005783 ! endoplasmic reticulum
relationship: occurs_in GO:0005783 ! endoplasmic reticulum

[Term]
id: GO:0033580
name: protein galactosylation at cell surface
namespace: biological_process
def: "The addition of a galactose unit to a protein amino acid at the surface of a cell." [GOC:mah]
synonym: "protein amino acid galactosylation at cell surface" EXACT [GOC:bf]
is_a: GO:0033575 ! protein glycosylation at cell surface
is_a: GO:0042125 ! protein galactosylation

[Term]
id: GO:0033581
name: protein galactosylation in Golgi
namespace: biological_process
def: "The addition of a galactose unit to a protein amino acid in any compartment of the Golgi apparatus." [GOC:mah]
synonym: "protein amino acid galactosylation in Golgi" EXACT [GOC:bf]
is_a: GO:0033578 ! protein glycosylation in Golgi
is_a: GO:0042125 ! protein galactosylation
intersection_of: GO:0042125 ! protein galactosylation
intersection_of: occurs_in GO:0005794 ! Golgi apparatus
relationship: occurs_in GO:0005794 ! Golgi apparatus

[Term]
id: GO:0033582
name: protein galactosylation in cytosol
namespace: biological_process
def: "The addition of a galactose unit to a protein amino acid in the cytosol." [GOC:mah]
synonym: "protein amino acid galactosylation in cytosol" EXACT [GOC:bf]
is_a: GO:0033576 ! protein glycosylation in cytosol
is_a: GO:0042125 ! protein galactosylation
intersection_of: GO:0042125 ! protein galactosylation
intersection_of: occurs_in GO:0005829 ! cytosol
relationship: occurs_in GO:0005829 ! cytosol

[Term]
id: GO:0033583
name: rhabdomere membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding the rhabdomere." [GOC:mah]
is_a: GO:0031253 ! cell projection membrane
relationship: part_of GO:0016028 ! rhabdomere

[Term]
id: GO:0033584
name: tyrosine biosynthetic process from chorismate via L-arogenate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tyrosine from other compounds, including chorismate, via the intermediate L-arogenate." [GOC:mah, MetaCyc:PWY-3461]
subset: gosubset_prok
synonym: "tyrosine anabolism from chorismate via L-arogenate" EXACT []
synonym: "tyrosine formation from chorismate via L-arogenate" EXACT []
synonym: "tyrosine synthesis from chorismate via L-arogenate" EXACT []
xref: MetaCyc:PWY-3461
is_a: GO:0006571 ! tyrosine biosynthetic process
is_a: GO:0046417 ! chorismate metabolic process

[Term]
id: GO:0033585
name: L-phenylalanine biosynthetic process from chorismate via phenylpyruvate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-phenylalanine from other compounds, including chorismate, via the intermediate phenylpyruvate." [GOC:go_curators]
subset: gosubset_prok
synonym: "L-phenylalanine anabolism from chorismate via phenylpyruvate" EXACT []
synonym: "L-phenylalanine biosynthesis from chorismate via phenylpyruvate" EXACT []
synonym: "L-phenylalanine formation from chorismate via phenylpyruvate" EXACT []
synonym: "L-phenylalanine synthesis from chorismate via phenylpyruvate" EXACT []
xref: MetaCyc:PHESYN
is_a: GO:0009094 ! L-phenylalanine biosynthetic process
is_a: GO:0046417 ! chorismate metabolic process

[Term]
id: GO:0033586
name: L-phenylalanine biosynthetic process from chorismate via L-arogenate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-phenylalanine from other compounds, including chorismate, via the intermediate L-arogenate." [GOC:go_curators]
subset: gosubset_prok
synonym: "L-phenylalanine anabolism from chorismate via L-arogenate" EXACT []
synonym: "L-phenylalanine biosynthesis from chorismate via L-arogenate" EXACT []
synonym: "L-phenylalanine formation from chorismate via L-arogenate" EXACT []
synonym: "L-phenylalanine synthesis from chorismate via L-arogenate" EXACT []
xref: MetaCyc:PWY-3462
is_a: GO:0009094 ! L-phenylalanine biosynthetic process
is_a: GO:0046417 ! chorismate metabolic process

[Term]
id: GO:0033587
name: shikimate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of shikimate, (3R,4S,5R)--3,4,5-trihydroxycyclohex-1-ene-1-carboxylate, the anion of shikimic acid." [CHEBI:36208, GOC:mah]
synonym: "shikimate anabolism" EXACT []
synonym: "shikimate biosynthesis" EXACT []
synonym: "shikimate formation" EXACT []
synonym: "shikimate synthesis" EXACT []
is_a: GO:0019632 ! shikimate metabolic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process

[Term]
id: GO:0033588
name: Elongator holoenzyme complex
namespace: cellular_component
alt_id: GO:0033589
def: "A heterohexameric protein complex that is involved in modification of wobble nucleosides in tRNA. The complex can associate physically with hyperphosphorylated RNA polymerase II; it contains two discrete heterotrimeric subcomplexes." [GOC:bhm, GOC:jh, GOC:mah, GOC:vw, PMID:11435442, PMID:11689709, PMID:15769872, PMID:17018299, PMID:18755837, PMID:23165209]
comment: Despite its name, this complex is no longer thought to be directly involved in transcriptional elongation (PMID:23165209).
synonym: "Elongator core complex" RELATED []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0033590
name: response to cobalamin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalamin (vitamin B12) stimulus." [GOC:sl]
synonym: "response to vitamin B12" EXACT []
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033273 ! response to vitamin
is_a: GO:1990267 ! response to transition metal nanoparticle

[Term]
id: GO:0033591
name: response to L-ascorbic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an L-ascorbic acid (vitamin C) stimulus." [GOC:sl]
synonym: "response to ascorbic acid" BROAD []
synonym: "response to L-ascorbate" EXACT []
synonym: "response to vitamin C" EXACT []
is_a: GO:0001101 ! response to acid chemical
is_a: GO:0033273 ! response to vitamin
is_a: GO:0034284 ! response to monosaccharide

[Term]
id: GO:0033592
name: RNA strand annealing activity
namespace: molecular_function
def: "Facilitates the base-pairing of complementary single-stranded RNA." [GOC:mah]
is_a: GO:0003725 ! double-stranded RNA binding
is_a: GO:0003727 ! single-stranded RNA binding
is_a: GO:0097617 ! annealing activity

[Term]
id: GO:0033593
name: BRCA2-MAGE-D1 complex
namespace: cellular_component
def: "A heterodimeric protein complex formed of BRCA2 and MAGE-D1; may mediate the synergistic activities of the two proteins in regulating cell growth." [PMID:15930293]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0033594
name: response to hydroxyisoflavone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyisoflavone stimulus." [CHEBI:38755, GOC:mah]
is_a: GO:0080184 ! response to phenylpropanoid
is_a: GO:1901654 ! response to ketone

[Term]
id: GO:0033595
name: response to genistein
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a genistein stimulus." [CHEBI:28088, GOC:mah]
is_a: GO:0033594 ! response to hydroxyisoflavone
is_a: GO:0043627 ! response to estrogen

[Term]
id: GO:0033596
name: TSC1-TSC2 complex
namespace: cellular_component
def: "A protein complex consisting of at least tumerin and hamartin; its formation may regulate hamartin homomultimer formation. The complex acts as a GTPase activating protein (GAP) for the small GTPase (Rheb), and inhibits the TOR signaling pathway." [PMID:10585443, PMID:17121544, PMID:9580671]
synonym: "tuberin-hamartin complex" EXACT []
synonym: "tuberous sclerosis complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0033597
name: mitotic checkpoint complex
namespace: cellular_component
def: "A multiprotein complex that functions as a mitotic checkpoint inhibitor of the anaphase-promoting complex/cyclosome (APC/C). In budding yeast this complex consists of Mad2p, Mad3p, Bub3p and Cdc20p, and in mammalian cells it consists of MAD2, BUBR1, BUB3, and CDC20." [PMID:10704439, PMID:11535616, PMID:11726501, PMID:17650307]
synonym: "MCC" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part
relationship: has_part GO:1990298 ! bub1-bub3 complex

[Term]
id: GO:0033598
name: mammary gland epithelial cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of mammary gland epithelial cells, resulting in the expansion of a cell population. Mammary gland epithelial cells make up the covering of surfaces of the mammary gland. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk." [GOC:dph, GOC:mah]
is_a: GO:0050673 ! epithelial cell proliferation
relationship: part_of GO:0061180 ! mammary gland epithelium development

[Term]
id: GO:0033599
name: regulation of mammary gland epithelial cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mammary gland epithelial cell proliferation." [GOC:mah]
is_a: GO:0050678 ! regulation of epithelial cell proliferation
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0033598 ! mammary gland epithelial cell proliferation
relationship: regulates GO:0033598 ! mammary gland epithelial cell proliferation

[Term]
id: GO:0033600
name: negative regulation of mammary gland epithelial cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of mammary gland epithelial cell proliferation." [GOC:mah]
synonym: "down regulation of mammary gland epithelial cell proliferation" EXACT []
synonym: "down-regulation of mammary gland epithelial cell proliferation" EXACT []
synonym: "downregulation of mammary gland epithelial cell proliferation" EXACT []
synonym: "inhibition of mammary gland epithelial cell proliferation" NARROW []
is_a: GO:0033599 ! regulation of mammary gland epithelial cell proliferation
is_a: GO:0050680 ! negative regulation of epithelial cell proliferation
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0033598 ! mammary gland epithelial cell proliferation
relationship: negatively_regulates GO:0033598 ! mammary gland epithelial cell proliferation

[Term]
id: GO:0033601
name: positive regulation of mammary gland epithelial cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of mammary gland epithelial cell proliferation." [GOC:mah]
synonym: "activation of mammary gland epithelial cell proliferation" NARROW []
synonym: "stimulation of mammary gland epithelial cell proliferation" NARROW []
synonym: "up regulation of mammary gland epithelial cell proliferation" EXACT []
synonym: "up-regulation of mammary gland epithelial cell proliferation" EXACT []
synonym: "upregulation of mammary gland epithelial cell proliferation" EXACT []
is_a: GO:0033599 ! regulation of mammary gland epithelial cell proliferation
is_a: GO:0050679 ! positive regulation of epithelial cell proliferation
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0033598 ! mammary gland epithelial cell proliferation
relationship: positively_regulates GO:0033598 ! mammary gland epithelial cell proliferation

[Term]
id: GO:0033602
name: negative regulation of dopamine secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of dopamine." [GOC:sl]
synonym: "down regulation of dopamine secretion" EXACT []
synonym: "down-regulation of dopamine secretion" EXACT []
synonym: "downregulation of dopamine secretion" EXACT []
synonym: "inhibition of dopamine secretion" NARROW []
is_a: GO:0014059 ! regulation of dopamine secretion
is_a: GO:0033604 ! negative regulation of catecholamine secretion
is_a: GO:1903792 ! negative regulation of anion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0014046 ! dopamine secretion
relationship: negatively_regulates GO:0014046 ! dopamine secretion

[Term]
id: GO:0033603
name: positive regulation of dopamine secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of dopamine." [GOC:sl]
synonym: "activation of dopamine secretion" NARROW []
synonym: "stimulation of dopamine secretion" NARROW []
synonym: "up regulation of dopamine secretion" EXACT []
synonym: "up-regulation of dopamine secretion" EXACT []
synonym: "upregulation of dopamine secretion" EXACT []
is_a: GO:0014059 ! regulation of dopamine secretion
is_a: GO:0033605 ! positive regulation of catecholamine secretion
is_a: GO:1903793 ! positive regulation of anion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0014046 ! dopamine secretion
relationship: positively_regulates GO:0014046 ! dopamine secretion

[Term]
id: GO:0033604
name: negative regulation of catecholamine secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a catecholamine." [GOC:mah]
synonym: "down regulation of catecholamine secretion" EXACT []
synonym: "down-regulation of catecholamine secretion" EXACT []
synonym: "downregulation of catecholamine secretion" EXACT []
synonym: "inhibition of catecholamine secretion" NARROW []
is_a: GO:0050433 ! regulation of catecholamine secretion
is_a: GO:0051953 ! negative regulation of amine transport
is_a: GO:1903531 ! negative regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0050432 ! catecholamine secretion
relationship: negatively_regulates GO:0050432 ! catecholamine secretion

[Term]
id: GO:0033605
name: positive regulation of catecholamine secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a catecholamine." [GOC:mah]
synonym: "activation of catecholamine secretion" NARROW []
synonym: "stimulation of catecholamine secretion" NARROW []
synonym: "up regulation of catecholamine secretion" EXACT []
synonym: "up-regulation of catecholamine secretion" EXACT []
synonym: "upregulation of catecholamine secretion" EXACT []
is_a: GO:0050433 ! regulation of catecholamine secretion
is_a: GO:0051954 ! positive regulation of amine transport
is_a: GO:1903532 ! positive regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0050432 ! catecholamine secretion
relationship: positively_regulates GO:0050432 ! catecholamine secretion

[Term]
id: GO:0033606
name: chemokine receptor transport within lipid bilayer
namespace: biological_process
def: "The directed movement of a chemokine receptor within a lipid bilayer." [GOC:mah]
synonym: "chemokine receptor translocation within membrane" EXACT []
is_a: GO:0032594 ! protein transport within lipid bilayer

[Term]
id: GO:0033607
name: SOD1-Bcl-2 complex
namespace: cellular_component
def: "A heterodimeric protein complex formed of superoxide dismutase 1 and Bcl-2. Complex formation is thought to link superoxide dismutase to an apoptotic pathway." [PMID:15233914, PMID:16790527]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0033608
name: formyl-CoA transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: formyl-CoA + oxalate = formate + oxalyl-CoA." [EC:2.8.3.16, RHEA:16548]
synonym: "formyl-CoA oxalate CoA-transferase activity" EXACT [EC:2.8.3.16]
synonym: "formyl-CoA:oxalate CoA-transferase activity" EXACT [EC:2.8.3.16]
synonym: "formyl-coenzyme A transferase activity" EXACT [EC:2.8.3.16]
xref: EC:2.8.3.16
xref: KEGG:R07290
xref: MetaCyc:RXN0-1382
xref: RHEA:16548
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0033609
name: oxalate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving oxalate, the organic acid ethanedioate." [CHEBI:30623, GOC:mlg]
synonym: "ethanedioate metabolic process" EXACT []
synonym: "ethanedioic acid metabolic process" EXACT []
synonym: "oxalate metabolism" EXACT []
synonym: "oxalic acid metabolic process" EXACT []
is_a: GO:0043648 ! dicarboxylic acid metabolic process

[Term]
id: GO:0033610
name: oxalate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of oxalate, the organic acid ethanedioate." [CHEBI:30623, GOC:mlg]
synonym: "ethanedioate biosynthetic process" EXACT []
synonym: "ethanedioic acid biosynthetic process" EXACT []
synonym: "oxalate anabolism" EXACT []
synonym: "oxalate biosynthesis" EXACT []
synonym: "oxalate formation" EXACT []
synonym: "oxalate synthesis" EXACT []
synonym: "oxalic acid biosynthetic process" EXACT []
is_a: GO:0033609 ! oxalate metabolic process
is_a: GO:0043650 ! dicarboxylic acid biosynthetic process

[Term]
id: GO:0033611
name: oxalate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of oxalate, the organic acid ethanedioate." [CHEBI:30623, GOC:mlg]
synonym: "ethanedioate catabolic process" EXACT []
synonym: "ethanedioic acid catabolic process" EXACT []
synonym: "oxalate breakdown" EXACT []
synonym: "oxalate catabolism" EXACT []
synonym: "oxalate degradation" EXACT []
synonym: "oxalic acid catabolic process" EXACT []
is_a: GO:0033609 ! oxalate metabolic process
is_a: GO:0043649 ! dicarboxylic acid catabolic process

[Term]
id: GO:0033612
name: receptor serine/threonine kinase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a receptor that possesses protein serine/threonine kinase activity." [GOC:mah]
synonym: "transmembrane receptor protein serine/threonine kinase ligand binding" RELATED []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0033613
name: activating transcription factor binding
namespace: molecular_function
alt_id: GO:0001107
def: "Interacting selectively and non-covalently with an activating transcription factor, any protein whose activity is required to initiate or upregulate transcription." [GOC:mah, GOC:txnOH]
synonym: "transcription activator binding" EXACT []
is_a: GO:0008134 ! transcription factor binding

[Term]
id: GO:0033614
name: chloroplast proton-transporting ATP synthase complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a proton-transporting ATP synthase in the chloroplast thylakoid membrane." [GOC:mah]
is_a: GO:0043461 ! proton-transporting ATP synthase complex assembly
relationship: part_of GO:0009658 ! chloroplast organization

[Term]
id: GO:0033615
name: mitochondrial proton-transporting ATP synthase complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a proton-transporting ATP synthase in the mitochondrial inner membrane." [GOC:mah]
is_a: GO:0043461 ! proton-transporting ATP synthase complex assembly
intersection_of: GO:0043461 ! proton-transporting ATP synthase complex assembly
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion
relationship: part_of GO:0007005 ! mitochondrion organization

[Term]
id: GO:0033616
name: plasma membrane proton-transporting ATP synthase complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a proton-transporting ATP synthase in the plasma membrane." [GOC:mah]
is_a: GO:0043461 ! proton-transporting ATP synthase complex assembly
relationship: part_of GO:0007009 ! plasma membrane organization

[Term]
id: GO:0033617
name: mitochondrial respiratory chain complex IV assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase) in the mitochondrial inner membrane." [GOC:mah]
subset: gosubset_prok
synonym: "mitochondrial cytochrome c oxidase biogenesis" BROAD []
synonym: "mitochondrial cytochrome c oxidase complex assembly" EXACT []
is_a: GO:0008535 ! respiratory chain complex IV assembly
is_a: GO:0033108 ! mitochondrial respiratory chain complex assembly
is_a: GO:0097034 ! mitochondrial respiratory chain complex IV biogenesis
intersection_of: GO:0008535 ! respiratory chain complex IV assembly
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion

[Term]
id: GO:0033618
name: plasma membrane respiratory chain complex IV assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase) in the plasma membrane." [GOC:mah]
subset: gosubset_prok
synonym: "plasma membrane cytochrome c oxidase biogenesis" BROAD []
synonym: "plasma membrane cytochrome c oxidase complex assembly" EXACT []
is_a: GO:0008535 ! respiratory chain complex IV assembly
relationship: part_of GO:0007009 ! plasma membrane organization

[Term]
id: GO:0033619
name: membrane protein proteolysis
namespace: biological_process
def: "The proteolytic cleavage of a transmembrane protein leading to the release of its intracellular or ecto-domains." [GOC:pde]
subset: gosubset_prok
is_a: GO:0006508 ! proteolysis

[Term]
id: GO:0033620
name: Mei2 nuclear dot complex
namespace: cellular_component
def: "A ribonucleoprotein complex that forms during meiotic prophase in a fixed position in the horsetail nucleus; contains Mei2 and meiRNA. May play a role in the progression of meiosis I." [GOC:vw, PMID:12808043]
synonym: "Mei2 dot" EXACT []
synonym: "Mei2 nuclear dot" BROAD []
synonym: "nuclear body" RELATED []
is_a: GO:0030529 ! intracellular ribonucleoprotein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0033621
name: nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts
namespace: biological_process
def: "The chemical reactions and pathways resulting in the selective degradation of meiosis-specific transcripts during vegetative growth, by a mechanism that requires determinant of selective removal (DSR) sequences in the targeted mRNAs and involves a YTH family protein." [PMID:16823445]
comment: Note that it is speculated that higher eukaryotic YTH-family protein may be involved in similar mechanisms to supress gene regulation during gametogenesis or general silencing.
synonym: "degradation of meiosis-specific transcripts" EXACT []
synonym: "mRNA breakdown, meiosis-specific transcripts" EXACT []
synonym: "mRNA catabolism, meiosis-specific transcripts" EXACT []
synonym: "mRNA degradation, meiosis-specific transcripts" EXACT []
synonym: "nuclear mRNA catabolic process, meiosis-specific transcripts" EXACT []
is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process

[Term]
id: GO:0033622
name: integrin activation
namespace: biological_process
def: "The aggregation, arrangement and bonding together of an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits, that lead to the increased affinity of the integrin for its extracellular ligands." [GOC:add, PMID:12213832, PMID:14754902]
synonym: "integrin complex activation" EXACT []
synonym: "integrin complex assembly" EXACT []
is_a: GO:0006461 ! protein complex assembly

[Term]
id: GO:0033623
name: regulation of integrin activation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of integrin activation." [GOC:add]
synonym: "regulation of integrin complex activation" EXACT []
is_a: GO:0043254 ! regulation of protein complex assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0033622 ! integrin activation
relationship: regulates GO:0033622 ! integrin activation

[Term]
id: GO:0033624
name: negative regulation of integrin activation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of integrin activation." [GOC:add]
synonym: "negative regulation of integrin complex activation" EXACT []
is_a: GO:0031333 ! negative regulation of protein complex assembly
is_a: GO:0033623 ! regulation of integrin activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0033622 ! integrin activation
relationship: negatively_regulates GO:0033622 ! integrin activation

[Term]
id: GO:0033625
name: positive regulation of integrin activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of integrin activation." [GOC:add]
synonym: "positive regulation of integrin complex activation" EXACT []
is_a: GO:0031334 ! positive regulation of protein complex assembly
is_a: GO:0033623 ! regulation of integrin activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0033622 ! integrin activation
relationship: positively_regulates GO:0033622 ! integrin activation

[Term]
id: GO:0033626
name: positive regulation of integrin activation by cell surface receptor linked signal transduction
namespace: biological_process
def: "Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell that lead to the increased affinity of an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits, for its extracellular ligands." [GOC:add, PMID:12213832, PMID:14754902]
synonym: "cell surface receptor linked signal transduction leading to integrin activation" EXACT [GOC:bf, GOC:signaling]
synonym: "cell surface receptor linked signal transduction leading to integrin complex activation" EXACT []
is_a: GO:0007166 ! cell surface receptor signaling pathway
is_a: GO:0033625 ! positive regulation of integrin activation
intersection_of: GO:0007166 ! cell surface receptor signaling pathway
intersection_of: positively_regulates GO:0033622 ! integrin activation
relationship: positively_regulates GO:0033622 ! integrin activation

[Term]
id: GO:0033627
name: cell adhesion mediated by integrin
namespace: biological_process
def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits." [GOC:add, PMID:12213832, PMID:14754902]
synonym: "cell adhesion mediated by integrin complex" EXACT []
is_a: GO:0007155 ! cell adhesion

[Term]
id: GO:0033628
name: regulation of cell adhesion mediated by integrin
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of cell adhesion mediated by integrin." [GOC:add]
synonym: "regulation of cell adhesion mediated by integrin complex" EXACT []
is_a: GO:0030155 ! regulation of cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0033627 ! cell adhesion mediated by integrin
relationship: regulates GO:0033627 ! cell adhesion mediated by integrin

[Term]
id: GO:0033629
name: negative regulation of cell adhesion mediated by integrin
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cell adhesion mediated by integrin." [GOC:add]
synonym: "negative regulation of cell adhesion mediated by integrin complex" EXACT []
is_a: GO:0007162 ! negative regulation of cell adhesion
is_a: GO:0033628 ! regulation of cell adhesion mediated by integrin
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0033627 ! cell adhesion mediated by integrin
relationship: negatively_regulates GO:0033627 ! cell adhesion mediated by integrin

[Term]
id: GO:0033630
name: positive regulation of cell adhesion mediated by integrin
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of cell adhesion mediated by integrin." [GOC:add]
synonym: "positive regulation of cell adhesion mediated by integrin complex" EXACT []
is_a: GO:0033628 ! regulation of cell adhesion mediated by integrin
is_a: GO:0045785 ! positive regulation of cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0033627 ! cell adhesion mediated by integrin
relationship: positively_regulates GO:0033627 ! cell adhesion mediated by integrin

[Term]
id: GO:0033631
name: cell-cell adhesion mediated by integrin
namespace: biological_process
def: "The attachment of one cell to another cell via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits." [GOC:add, PMID:12213832, PMID:14754902]
synonym: "cell-cell adhesion mediated by integrin complex" EXACT []
is_a: GO:0016337 ! single organismal cell-cell adhesion
is_a: GO:0033627 ! cell adhesion mediated by integrin

[Term]
id: GO:0033632
name: regulation of cell-cell adhesion mediated by integrin
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of cell-cell adhesion mediated by integrin." [GOC:add]
synonym: "regulation of cell-cell adhesion mediated by integrin complex" EXACT []
is_a: GO:0022407 ! regulation of cell-cell adhesion
is_a: GO:0033628 ! regulation of cell adhesion mediated by integrin
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0033631 ! cell-cell adhesion mediated by integrin
relationship: regulates GO:0033631 ! cell-cell adhesion mediated by integrin

[Term]
id: GO:0033633
name: negative regulation of cell-cell adhesion mediated by integrin
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cell-cell adhesion mediated by integrin." [GOC:add]
synonym: "negative regulation of cell-cell adhesion mediated by integrin complex" EXACT []
is_a: GO:0022408 ! negative regulation of cell-cell adhesion
is_a: GO:0033629 ! negative regulation of cell adhesion mediated by integrin
is_a: GO:0033632 ! regulation of cell-cell adhesion mediated by integrin
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0033631 ! cell-cell adhesion mediated by integrin
relationship: negatively_regulates GO:0033631 ! cell-cell adhesion mediated by integrin

[Term]
id: GO:0033634
name: positive regulation of cell-cell adhesion mediated by integrin
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of cell-cell adhesion mediated by integrin." [GOC:add]
synonym: "positive regulation of cell-cell adhesion mediated by integrin complex" EXACT []
is_a: GO:0022409 ! positive regulation of cell-cell adhesion
is_a: GO:0033630 ! positive regulation of cell adhesion mediated by integrin
is_a: GO:0033632 ! regulation of cell-cell adhesion mediated by integrin
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0033631 ! cell-cell adhesion mediated by integrin
relationship: positively_regulates GO:0033631 ! cell-cell adhesion mediated by integrin

[Term]
id: GO:0033635
name: modulation by symbiont of host response to abiotic stimulus
namespace: biological_process
def: "Any process in which an organism modulates a change in the state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0044003 ! modification by symbiont of host morphology or physiology

[Term]
id: GO:0033636
name: modulation by symbiont of host response to temperature stimulus
namespace: biological_process
def: "Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "modulation by symbiont of host response to thermal stimulus" EXACT []
is_a: GO:0033635 ! modulation by symbiont of host response to abiotic stimulus

[Term]
id: GO:0033637
name: modulation by symbiont of host response to cold
namespace: biological_process
def: "Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "freezing tolerance" RELATED []
is_a: GO:0033636 ! modulation by symbiont of host response to temperature stimulus

[Term]
id: GO:0033638
name: modulation by symbiont of host response to heat
namespace: biological_process
def: "Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "response to heat shock" RELATED []
is_a: GO:0033636 ! modulation by symbiont of host response to temperature stimulus

[Term]
id: GO:0033639
name: modulation by symbiont of host response to water
namespace: biological_process
def: "Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0033635 ! modulation by symbiont of host response to abiotic stimulus

[Term]
id: GO:0033640
name: modulation by symbiont of host response to osmotic stress
namespace: biological_process
def: "Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0033635 ! modulation by symbiont of host response to abiotic stimulus

[Term]
id: GO:0033641
name: modulation by symbiont of host response to pH
namespace: biological_process
def: "Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0033635 ! modulation by symbiont of host response to abiotic stimulus

[Term]
id: GO:0033642
name: modulation by symbiont of host response to gravitational stimulus
namespace: biological_process
def: "Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "response to gravitational stimulus" BROAD []
is_a: GO:0033635 ! modulation by symbiont of host response to abiotic stimulus

[Term]
id: GO:0033643
name: host cell part
namespace: cellular_component
def: "Any constituent part of a host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: goantislim_grouping
subset: gocheck_do_not_annotate
subset: gosubset_prok
is_a: GO:0044217 ! other organism part
intersection_of: GO:0005575 ! cellular_component
intersection_of: part_of GO:0043657 ! host cell
relationship: part_of GO:0043657 ! host cell

[Term]
id: GO:0033644
name: host cell membrane
namespace: cellular_component
def: "Double layer of lipid molecules as it encloses host cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
subset: gosubset_prok
is_a: GO:0033643 ! host cell part
is_a: GO:0044218 ! other organism cell membrane

[Term]
id: GO:0033645
name: host cell endomembrane system
namespace: cellular_component
def: "A collection of membranous structures involved in transport within the host cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0033644 ! host cell membrane

[Term]
id: GO:0033646
name: host intracellular part
namespace: cellular_component
def: "Any constituent part of the living contents of a host cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
subset: gosubset_prok
synonym: "host cell intracellular part" EXACT []
is_a: GO:0033643 ! host cell part
relationship: part_of GO:0043656 ! intracellular region of host

[Term]
id: GO:0033647
name: host intracellular organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, occurring within the host cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
subset: gosubset_prok
is_a: GO:0033646 ! host intracellular part

[Term]
id: GO:0033648
name: host intracellular membrane-bounded organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, as found in host cells, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
subset: gosubset_prok
synonym: "host intracellular membrane-enclosed organelle" EXACT []
is_a: GO:0033647 ! host intracellular organelle

[Term]
id: GO:0033650
name: host cell mitochondrion
namespace: cellular_component
def: "A semiautonomous, self replicating organelle as found in host cells that occurs in varying numbers, shapes, and sizes in the cell cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "host mitochondria" EXACT []
is_a: GO:0033648 ! host intracellular membrane-bounded organelle
is_a: GO:0033655 ! host cell cytoplasm part

[Term]
id: GO:0033651
name: host cell plastid
namespace: cellular_component
def: "Any member of a family of organelles as found in the cytoplasm of host cells, which are membrane-bounded and contain DNA. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0033648 ! host intracellular membrane-bounded organelle
is_a: GO:0033655 ! host cell cytoplasm part

[Term]
id: GO:0033652
name: host cell chloroplast
namespace: cellular_component
def: "A chlorophyll-containing plastid as found within host cells with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0033651 ! host cell plastid

[Term]
id: GO:0033653
name: host cell chloroplast part
namespace: cellular_component
def: "Any constituent part of a chloroplast as it is found in host cells and which are a chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "host chloroplast component" EXACT []
is_a: GO:0033652 ! host cell chloroplast

[Term]
id: GO:0033654
name: host cell chloroplast thylakoid membrane
namespace: cellular_component
def: "Any sac-like membranous structures (cisternae) in a chloroplast found in host cells, combined into stacks (grana) and present singly in the stroma (stroma thylakoids or frets) as interconnections between grana. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0033653 ! host cell chloroplast part
is_a: GO:0044160 ! host thylakoid membrane

[Term]
id: GO:0033655
name: host cell cytoplasm part
namespace: cellular_component
def: "Any constituent part of the host cell cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
subset: gosubset_prok
synonym: "cytoplasm component" BROAD []
is_a: GO:0033646 ! host intracellular part
relationship: part_of GO:0030430 ! host cell cytoplasm

[Term]
id: GO:0033656
name: modification by symbiont of host chloroplast
namespace: biological_process
def: "The process in which an organism effects a change in the structure or function of host cell chloroplasts. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0052043 ! modification by symbiont of host cellular component

[Term]
id: GO:0033657
name: modification by symbiont of host chloroplast part
namespace: biological_process
def: "The process in which an organism effects a change in the structure or function of a component of the host cell chloroplast. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0033656 ! modification by symbiont of host chloroplast

[Term]
id: GO:0033658
name: modification by symbiont of host chloroplast thylakoid
namespace: biological_process
def: "The process in which an organism effects a change in the structure or function of the host cell chloroplast thylakoid. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0033657 ! modification by symbiont of host chloroplast part

[Term]
id: GO:0033659
name: modification by symbiont of host mitochondrion
namespace: biological_process
def: "The process in which an organism effects a change in the structure or function of host cell mitochondria. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0052043 ! modification by symbiont of host cellular component

[Term]
id: GO:0033660
name: negative regulation by symbiont of host resistance gene-dependent defense response
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the resistance gene-dependent defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "down regulation by symbiont of defense response in host by specific elicitors" EXACT []
synonym: "down-regulation by symbiont of host gene-for-gene resistance" EXACT []
synonym: "downregulation by symbiont of pathogen-race/host plant cultivar-specific resistance in symbiont" EXACT []
synonym: "inhibition by symbiont of host resistance gene-dependent defense response" NARROW []
synonym: "suppression by symbiont of host resistance gene-dependent defense response" EXACT []
is_a: GO:0052037 ! negative regulation by symbiont of host defense response
is_a: GO:0052158 ! modulation by symbiont of host resistance gene-dependent defense response

[Term]
id: GO:0033661
name: negative regulation by symbiont of defense-related host reactive oxygen species production
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the production of reactive oxygen species as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "down regulation by organism of defense-related host metabolic burst" EXACT []
synonym: "down-regulation by organism of defense-related host oxidative burst" EXACT []
synonym: "downregulation by organism of defense-related host AOS production" EXACT []
synonym: "inhibition by organism of defense-related host active oxygen species production" NARROW []
synonym: "negative regulation by organism of defense-related host reactive oxidative species production" EXACT []
synonym: "negative regulation by organism of defense-related host reactive oxygen intermediate production" EXACT []
synonym: "negative regulation by organism of defense-related host respiratory burst" EXACT []
synonym: "negative regulation by organism of defense-related host ROI production" EXACT []
synonym: "negative regulation by organism of defense-related host ROS production" EXACT []
is_a: GO:0052037 ! negative regulation by symbiont of host defense response
is_a: GO:0052164 ! modulation by symbiont of defense-related host reactive oxygen species production

[Term]
id: GO:0033662
name: modulation by symbiont of host defense-related protein level
namespace: biological_process
def: "The alternation by a symbiont of the levels of defense-related proteins in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0052031 ! modulation by symbiont of host defense response
is_a: GO:0075344 ! modulation by symbiont of host protein levels

[Term]
id: GO:0033663
name: negative regulation by symbiont of host defense-related protein level
namespace: biological_process
def: "Any process in which the symbiont stops or reduces of the levels of defense-related proteins in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0033662 ! modulation by symbiont of host defense-related protein level
is_a: GO:0052037 ! negative regulation by symbiont of host defense response

[Term]
id: GO:0033664
name: positive regulation by symbiont of host defense-related protein level
namespace: biological_process
def: "Any process in which the symbiont activates, maintains or increases levels of defense-related proteins in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0033662 ! modulation by symbiont of host defense-related protein level
is_a: GO:0052509 ! positive regulation by symbiont of host defense response

[Term]
id: GO:0033665
name: obsolete regulation of growth or development of symbiont in host
namespace: biological_process
def: "OBSOLETE. Any process by which the symbiont regulates the increase in its size or mass, or its progression from an initial condition to a later condition, within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:dph, GOC:pamgo_curators, GOC:tb]
comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'regulation of development of symbiont in host ; GO:0044127' and 'regulation of growth of symbiont in host ; GO:0044126'.
synonym: "modulation of growth or development of organism within host" EXACT []
synonym: "modulation of growth or development of symbiont within host" EXACT [GOC:dph, GOC:tb]
synonym: "modulation of invasive growth" BROAD []
synonym: "regulation of growth or development of symbiont in host" EXACT []
synonym: "regulation of growth or development of symbiont within host" EXACT []
is_obsolete: true
consider: GO:0044126
consider: GO:0044127

[Term]
id: GO:0033666
name: obsolete positive regulation of growth or development of symbiont in host
namespace: biological_process
def: "OBSOLETE. Any process by which the symbiont activates, maintains or increases its size or mass or its progression from an initial condition to a later condition, within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:pamgo_curators]
comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'positive regulation of development of symbiont in host ; GO:0044129' and 'positive regulation of growth of symbiont in host ; GO:0044128'.
synonym: "positive regulation of growth or development of symbiont in host" EXACT []
synonym: "positive regulation of growth or development of symbiont within host" EXACT []
synonym: "positive regulation of invasive growth" BROAD []
synonym: "up regulation of growth or development of organism within host" EXACT []
synonym: "up-regulation of growth or development of organism within host" EXACT []
synonym: "upregulation of growth or development of organism within host" EXACT []
is_obsolete: true
consider: GO:0044128
consider: GO:0044129

[Term]
id: GO:0033667
name: obsolete negative regulation of growth or development of symbiont in host
namespace: biological_process
def: "OBSOLETE. Any process by which the symbiont stops, prevents or reduces its increase in size or mass or its progression from an initial condition to a later condition, within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:pamgo_curators]
comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'negative regulation of development of symbiont in host ; GO:0044131' and 'negative regulation of growth of symbiont in host ; GO:0044130'.
synonym: "down regulation of growth or development of organism within host" EXACT []
synonym: "down-regulation of growth or development of organism within host" EXACT []
synonym: "downregulation of growth or development of organism within host" EXACT []
synonym: "inhibition of growth of development of organism within host" NARROW []
synonym: "negative regulation of growth or development of symbiont in host" EXACT []
synonym: "negative regulation of growth or development of symbiont within host" EXACT []
synonym: "negative regulation of invasive growth" BROAD []
is_obsolete: true
consider: GO:0044130
consider: GO:0044131

[Term]
id: GO:0033668
name: negative regulation by symbiont of host apoptotic process
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of programmed cell death in the host, where programmed cell death proceeds by apoptosis. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that term is to be used to annotate gene products in the symbiont. To annotate host gene products, consider the biological process term 'negative regulation of apoptosis ; GO:0043066'.
synonym: "down regulation by organism of host apoptotic programmed cell death" EXACT []
synonym: "down-regulation by organism of host apoptotic programmed cell death" EXACT []
synonym: "downregulation by organism of host apoptotic programmed cell death" EXACT []
synonym: "inhibition by organism of host apoptotic programmed cell death" NARROW []
synonym: "negative regulation by symbiont of host apoptosis" NARROW []
is_a: GO:0043066 ! negative regulation of apoptotic process
is_a: GO:0052041 ! negative regulation by symbiont of host programmed cell death
is_a: GO:0052150 ! modulation by symbiont of host apoptotic process

[Term]
id: GO:0033670
name: regulation of NAD+ kinase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of NAD kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an NAD molecule." [GOC:mah]
synonym: "NAD kinase regulator" NARROW []
synonym: "regulation of NAD kinase activity" EXACT []
is_a: GO:0043549 ! regulation of kinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003951 ! NAD+ kinase activity
relationship: regulates GO:0003951 ! NAD+ kinase activity

[Term]
id: GO:0033671
name: negative regulation of NAD+ kinase activity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of NAD kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an NAD molecule." [GOC:mah]
synonym: "down regulation of NAD+ kinase activity" EXACT []
synonym: "down-regulation of NAD+ kinase activity" EXACT []
synonym: "downregulation of NAD+ kinase activity" EXACT []
synonym: "inhibition of NAD+ kinase activity" NARROW []
synonym: "NAD+ kinase inhibitor" NARROW []
is_a: GO:0033670 ! regulation of NAD+ kinase activity
is_a: GO:0033673 ! negative regulation of kinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003951 ! NAD+ kinase activity
relationship: negatively_regulates GO:0003951 ! NAD+ kinase activity

[Term]
id: GO:0033672
name: positive regulation of NAD+ kinase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of NAD kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an NAD molecule." [GOC:mah]
synonym: "NAD+ kinase activator" NARROW []
synonym: "stimulation of NAD+ kinase activity" NARROW []
synonym: "up regulation of NAD+ kinase activity" EXACT []
synonym: "up-regulation of NAD+ kinase activity" EXACT []
synonym: "upregulation of NAD+ kinase activity" EXACT []
is_a: GO:0033670 ! regulation of NAD+ kinase activity
is_a: GO:0033674 ! positive regulation of kinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003951 ! NAD+ kinase activity
relationship: positively_regulates GO:0003951 ! NAD+ kinase activity

[Term]
id: GO:0033673
name: negative regulation of kinase activity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:mah]
synonym: "down regulation of kinase activity" EXACT []
synonym: "down-regulation of kinase activity" EXACT []
synonym: "downregulation of kinase activity" EXACT []
synonym: "inhibition of kinase activity" NARROW []
synonym: "kinase inhibitor" NARROW []
is_a: GO:0042326 ! negative regulation of phosphorylation
is_a: GO:0043549 ! regulation of kinase activity
is_a: GO:0051348 ! negative regulation of transferase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016301 ! kinase activity
relationship: negatively_regulates GO:0016301 ! kinase activity

[Term]
id: GO:0033674
name: positive regulation of kinase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:mah]
synonym: "kinase activator" NARROW []
synonym: "stimulation of kinase activity" NARROW []
synonym: "up regulation of kinase activity" EXACT []
synonym: "up-regulation of kinase activity" EXACT []
synonym: "upregulation of kinase activity" EXACT []
is_a: GO:0042327 ! positive regulation of phosphorylation
is_a: GO:0043549 ! regulation of kinase activity
is_a: GO:0051347 ! positive regulation of transferase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016301 ! kinase activity
relationship: positively_regulates GO:0016301 ! kinase activity

[Term]
id: GO:0033675
name: pericanalicular vesicle
namespace: cellular_component
def: "A membrane-bounded vesicle found near the apical, or pericanalicular, membrane of a hepatocyte; contains proteins involved in bile salt transport and other fluid and solute transport processes." [PMID:15763347, PMID:9790571]
is_a: GO:0016023 ! cytoplasmic, membrane-bounded vesicle

[Term]
id: GO:0033676
name: double-stranded DNA-dependent ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of double-stranded DNA, and it drives another reaction." [GOC:mah]
synonym: "dsDNA-dependent ATPase activity" EXACT []
is_a: GO:0008094 ! DNA-dependent ATPase activity

[Term]
id: GO:0033677
name: DNA/RNA helicase activity
namespace: molecular_function
def: "Catalysis of the reaction: NTP + H2O = NDP + phosphate; this reaction drives the unwinding of a DNA/RNA duplex, i.e. a double helix in which a strand of DNA pairs with a complementary strand of RNA." [GOC:mah]
subset: gosubset_prok
xref: EC:2.7.7.-
is_a: GO:0004386 ! helicase activity

[Term]
id: GO:0033678
name: 5'-3' DNA/RNA helicase activity
namespace: molecular_function
def: "Catalysis of the unwinding of a DNA/RNA duplex in the direction 5' to 3'." [GOC:mah]
synonym: "5' to 3' DNA/RNA helicase activity" EXACT []
is_a: GO:0033677 ! DNA/RNA helicase activity

[Term]
id: GO:0033679
name: 3'-5' DNA/RNA helicase activity
namespace: molecular_function
def: "Catalysis of the unwinding of a DNA/RNA duplex in the direction 3' to 5'." [GOC:mah]
synonym: "3' to 5' DNA/RNA helicase activity" EXACT []
is_a: GO:0033677 ! DNA/RNA helicase activity

[Term]
id: GO:0033680
name: ATP-dependent DNA/RNA helicase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of a DNA/RNA duplex." [GOC:mah]
subset: gosubset_prok
is_a: GO:0008026 ! ATP-dependent helicase activity
is_a: GO:0008094 ! DNA-dependent ATPase activity
is_a: GO:0033677 ! DNA/RNA helicase activity

[Term]
id: GO:0033681
name: ATP-dependent 3'-5' DNA/RNA helicase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of a DNA/RNA duplex in the direction 3' to 5'." [GOC:mah]
synonym: "ATP-dependent 3' to 5' DNA/RNA helicase activity" EXACT []
is_a: GO:0033679 ! 3'-5' DNA/RNA helicase activity
is_a: GO:0033680 ! ATP-dependent DNA/RNA helicase activity

[Term]
id: GO:0033682
name: ATP-dependent 5'-3' DNA/RNA helicase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of a DNA/RNA duplex in the direction 5' to 3'." [GOC:mah]
synonym: "ATP-dependent 5' to 3' DNA/RNA helicase activity" EXACT []
is_a: GO:0033678 ! 5'-3' DNA/RNA helicase activity
is_a: GO:0033680 ! ATP-dependent DNA/RNA helicase activity

[Term]
id: GO:0033683
name: nucleotide-excision repair, DNA incision
namespace: biological_process
def: "A process that results in the endonucleolytic cleavage of the damaged strand of DNA. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound." [GOC:elh, PMID:8631896]
subset: gosubset_prok
synonym: "DNA incision involved in nucleotide-excision repair" EXACT [GOC:dph, GOC:tb]
synonym: "nucleic acid cleavage involved in nucleotide-excision repair" EXACT [GOC:dph, GOC:tb]
is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis
intersection_of: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis
intersection_of: part_of GO:0006289 ! nucleotide-excision repair
relationship: part_of GO:0006289 ! nucleotide-excision repair

[Term]
id: GO:0033684
name: regulation of luteinizing hormone secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of luteinizing hormone." [GOC:mah]
is_a: GO:0032276 ! regulation of gonadotropin secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032275 ! luteinizing hormone secretion
relationship: regulates GO:0032275 ! luteinizing hormone secretion

[Term]
id: GO:0033685
name: negative regulation of luteinizing hormone secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of luteinizing hormone." [GOC:mah]
synonym: "down regulation of luteinizing hormone secretion" EXACT []
synonym: "down-regulation of luteinizing hormone secretion" EXACT []
synonym: "downregulation of luteinizing hormone secretion" EXACT []
synonym: "inhibition of luteinizing hormone secretion" NARROW []
is_a: GO:0032277 ! negative regulation of gonadotropin secretion
is_a: GO:0033684 ! regulation of luteinizing hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032275 ! luteinizing hormone secretion
relationship: negatively_regulates GO:0032275 ! luteinizing hormone secretion

[Term]
id: GO:0033686
name: positive regulation of luteinizing hormone secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of luteinizing hormone." [GOC:mah]
synonym: "activation of luteinizing hormone secretion" NARROW []
synonym: "stimulation of luteinizing hormone secretion" NARROW []
synonym: "up regulation of luteinizing hormone secretion" EXACT []
synonym: "up-regulation of luteinizing hormone secretion" EXACT []
synonym: "upregulation of luteinizing hormone secretion" EXACT []
is_a: GO:0032278 ! positive regulation of gonadotropin secretion
is_a: GO:0033684 ! regulation of luteinizing hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032275 ! luteinizing hormone secretion
relationship: positively_regulates GO:0032275 ! luteinizing hormone secretion

[Term]
id: GO:0033687
name: osteoblast proliferation
namespace: biological_process
def: "The multiplication or reproduction of osteoblasts, resulting in the expansion of an osteoblast cell population. An osteoblast is a bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone." [GOC:mah]
is_a: GO:0008283 ! cell proliferation

[Term]
id: GO:0033688
name: regulation of osteoblast proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of osteoblast proliferation." [GOC:mah]
is_a: GO:0042127 ! regulation of cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0033687 ! osteoblast proliferation
relationship: regulates GO:0033687 ! osteoblast proliferation

[Term]
id: GO:0033689
name: negative regulation of osteoblast proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of osteoblast proliferation." [GOC:mah]
synonym: "down regulation of osteoblast proliferation" EXACT []
synonym: "down-regulation of osteoblast proliferation" EXACT []
synonym: "downregulation of osteoblast proliferation" EXACT []
synonym: "inhibition of osteoblast proliferation" NARROW []
is_a: GO:0008285 ! negative regulation of cell proliferation
is_a: GO:0033688 ! regulation of osteoblast proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0033687 ! osteoblast proliferation
relationship: negatively_regulates GO:0033687 ! osteoblast proliferation

[Term]
id: GO:0033690
name: positive regulation of osteoblast proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of osteoblast proliferation." [GOC:mah]
synonym: "activation of osteoblast proliferation" NARROW []
synonym: "stimulation of osteoblast proliferation" NARROW []
synonym: "up regulation of osteoblast proliferation" EXACT []
synonym: "up-regulation of osteoblast proliferation" EXACT []
synonym: "upregulation of osteoblast proliferation" EXACT []
is_a: GO:0008284 ! positive regulation of cell proliferation
is_a: GO:0033688 ! regulation of osteoblast proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0033687 ! osteoblast proliferation
relationship: positively_regulates GO:0033687 ! osteoblast proliferation

[Term]
id: GO:0033691
name: sialic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with sialic acid, any of a variety of N- or O- substituted derivatives of neuraminic acid, a nine carbon monosaccharide. Sialic acids often occur in polysaccharides, glycoproteins, and glycolipids in animals and bacteria." [CHEBI:26667, GOC:add, http://www.biology-online.org, ISBN:0721601465]
synonym: "N-acetylneuraminic acid binding" NARROW []
is_a: GO:0031406 ! carboxylic acid binding
is_a: GO:0097367 ! carbohydrate derivative binding

[Term]
id: GO:0033692
name: cellular polysaccharide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of polysaccharides, polymers of many (typically more than 10) monosaccharide residues linked glycosidically, occurring at the level of an individual cell." [CHEBI:18154, GOC:go_curators]
subset: gosubset_prok
synonym: "cellular glycan biosynthesis" EXACT []
synonym: "cellular glycan biosynthetic process" EXACT []
synonym: "cellular polysaccharide anabolism" EXACT []
synonym: "cellular polysaccharide biosynthesis" EXACT []
synonym: "cellular polysaccharide formation" EXACT []
synonym: "cellular polysaccharide synthesis" EXACT []
is_a: GO:0000271 ! polysaccharide biosynthetic process
is_a: GO:0034637 ! cellular carbohydrate biosynthetic process
is_a: GO:0034645 ! cellular macromolecule biosynthetic process
is_a: GO:0044264 ! cellular polysaccharide metabolic process

[Term]
id: GO:0033693
name: neurofilament bundle assembly
namespace: biological_process
def: "The assembly of neurofilaments into bundles, in which the filaments are longitudinally oriented, with numerous crossbridges between them. Neurofilament bundles may be cross-linked to each other, to membrane-bounded organelles or other cytoskeletal structures such as microtubules." [PMID:11034913, PMID:11264295]
synonym: "NF bundle assembly" EXACT []
is_a: GO:0045110 ! intermediate filament bundle assembly
is_a: GO:0060052 ! neurofilament cytoskeleton organization

[Term]
id: GO:0033694
name: oxidoreductase activity, acting on the CH-NH group of donors, iron-sulfur protein as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:jl]
subset: gosubset_prok
xref: EC:1.5.7
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0033695
name: oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a quinone or similar acceptor molecule." [EC:1.17.5, GOC:mah]
subset: gosubset_prok
xref: EC:1.17.5
is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups

[Term]
id: GO:0033696
name: negative regulation of extent of heterochromatin assembly
namespace: biological_process
def: "Any process that reduces the extent of heterochromatin formation; reduces the size of a chromosomal region converted to heterochromatin." [GOC:mah]
synonym: "maintenance of heterochromatin boundaries" RELATED []
synonym: "negative regulation of extent of heterochromatin formation" EXACT []
synonym: "negative regulation of heterochromatin spreading" RELATED []
is_a: GO:0031452 ! negative regulation of heterochromatin assembly
is_a: GO:0031454 ! regulation of extent of heterochromatin assembly

[Term]
id: GO:0033697
name: positive regulation of extent of heterochromatin assembly
namespace: biological_process
def: "Any process that increases the extent of heterochromatin formation; increases the size of a chromosomal region converted to heterochromatin." [GOC:mah]
synonym: "positive regulation of extent of heterochromatin formation" EXACT []
synonym: "positive regulation of heterochromatin spreading" RELATED []
is_a: GO:0031453 ! positive regulation of heterochromatin assembly
is_a: GO:0031454 ! regulation of extent of heterochromatin assembly

[Term]
id: GO:0033698
name: Rpd3L complex
namespace: cellular_component
alt_id: GO:0000508
def: "A histone deacetylase complex which deacetylates histones across gene coding regions. Composed of a catalytic histone deacetylase subunit, an Sds-3 family protein, a SIN3 family co-repressor, a WD repeat protein, and a zf- PHD finger (Clr6, Sds3, Pst1, Prw1, Png2 in Schizosaccharomyces pombe; Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p and Ash1p in Saccharomyces cerevisiae)." [GOC:vw, PMID:17450151]
synonym: "Clr6 histone deacetylase complex I/I'" EXACT [GOC:rb, GOC:vw]
synonym: "Clr6L complex" EXACT [PMID:19040720]
synonym: "Rpd3C(L)" EXACT []
is_a: GO:0070822 ! Sin3-type complex

[Term]
id: GO:0033699
name: DNA 5'-adenosine monophosphate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5'-AMP-DNA + H2O = AMP + DNA; nucleophilic release of a covalently linked adenylate residue from a DNA strand, leaving a 5' phosphate terminus." [GOC:mah, PMID:16547001, PMID:17276982]
synonym: "AMP-removal activity" RELATED []
synonym: "DNA 5'-adenylate hydrolase activity" EXACT []
synonym: "DNA adenylate hydrolysis activity" BROAD []
synonym: "DNA de-adenylation" RELATED []
synonym: "DNA deadenylation" RELATED []
is_a: GO:0035312 ! 5'-3' exodeoxyribonuclease activity

[Term]
id: GO:0033700
name: phospholipid efflux
namespace: biological_process
def: "The directed movement of a phospholipid out of a cell or organelle." [GOC:mah]
synonym: "phospholipid export" EXACT []
is_a: GO:0015914 ! phospholipid transport

[Term]
id: GO:0033701
name: dTDP-galactose 6-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: dTDP-D-galactose + 2 NADP+ + H2O = dTDP-D-galacturonate + 2 NADPH + 2 H+." [EC:1.1.1.186]
synonym: "dTDP-D-galactose:NADP+ 6-oxidoreductase activity" EXACT [EC:1.1.1.186]
synonym: "dTDPgalactose 6-dehydrogenase activity" EXACT [EC:1.1.1.186]
synonym: "thymidine-diphosphate-galactose dehydrogenase activity" EXACT [EC:1.1.1.186]
xref: EC:1.1.1.186
xref: MetaCyc:DTDP-GALACTOSE-6-DEHYDROGENASE-RXN
xref: RHEA:12399
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033702
name: (+)-trans-carveol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (1R,5S)-carveol + NAD(+) = (S)-carvone + H(+) + NADH." [EC:1.1.1.275, RHEA:14828]
synonym: "(+)-trans-carveol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.275]
xref: EC:1.1.1.275
xref: KEGG:R06117
xref: MetaCyc:RXN-9397
xref: RHEA:14828
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033703
name: 3beta-hydroxy-5beta-steroid dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3beta-hydroxy-5beta-pregnane-20-one + NADP(+) = 5beta-pregnan-3,20-dione + H(+) + NADPH." [EC:1.1.1.277, RHEA:22947]
synonym: "3beta-hydroxy-5beta-steroid:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.277]
synonym: "3beta-hydroxysteroid 5beta-oxidoreductase activity" EXACT [EC:1.1.1.277]
synonym: "3beta-hydroxysteroid 5beta-progesterone oxidoreductase activity" EXACT [EC:1.1.1.277]
xref: EC:1.1.1.277
xref: KEGG:R06166
xref: MetaCyc:1.1.1.277-RXN
xref: RHEA:22947
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033704
name: 3beta-hydroxy-5alpha-steroid dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3beta-hydroxy-5alpha-pregnane-20-one + NADP(+) = 5alpha-pregnane-3,20-dione + H(+) + NADPH." [EC:1.1.1.278, RHEA:18140]
synonym: "3beta-hydroxy-5alpha-steroid:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.278]
xref: EC:1.1.1.278
xref: KEGG:R07138
xref: MetaCyc:1.1.1.278-RXN
xref: RHEA:18140
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033705
name: GDP-4-dehydro-6-deoxy-D-mannose reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-6-deoxy-D-mannose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H+." [EC:1.1.1.281]
comment: Note that this enzyme differs from EC 1.1.1.187, GDP-4-dehydro-D-rhamnose reductase, in that the only product formed is GDP-D-rhamnose (GDP-6-deoxy-D-mannose).
synonym: "GDP-4-keto-6-deoxy-D-mannose reductase activity" BROAD [EC:1.1.1.281]
synonym: "GDP-6-deoxy-D-lyxo-4-hexulose reductase activity" EXACT [EC:1.1.1.281]
synonym: "GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase (D-rhamnose-forming) activity" EXACT [EC:1.1.1.281]
synonym: "Rmd" RELATED [EC:1.1.1.281]
xref: EC:1.1.1.281
xref: MetaCyc:GDP-4-DEHYDRO-D-RHAMNOSE-REDUCTASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033706
name: obsolete quinate/shikimate dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reactions: L-quinate + NAD(P)+ = 3-dehydroquinate + NAD(P)H + H+, and shikimate + NAD(P)+ = 3-dehydroshikimate + NAD(P)H + H+." [EC:1.1.1.282]
comment: This term was made obsolete because it represents four reactions, and should be four separate terms.
synonym: "L-quinate:NAD(P)+ 3-oxidoreductase activity" EXACT [EC:1.1.1.282]
synonym: "quinate/shikimate dehydrogenase activity" EXACT []
synonym: "YdiB" RELATED [EC:1.1.1.282]
is_obsolete: true
consider: GO:0004764
consider: GO:0030266
consider: GO:0052733
consider: GO:0052734

[Term]
id: GO:0033707
name: 3''-deamino-3''-oxonicotianamine reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2'-deoxymugineic acid + NAD(P)+ = 3''-deamino-3''-oxonicotianamine + NAD(P)H + H+." [EC:1.1.1.285]
synonym: "2'-deoxymugineic acid:NAD(P)+ 3''-oxidoreductase activity" EXACT [EC:1.1.1.285]
xref: EC:1.1.1.285
xref: MetaCyc:1.1.1.285-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033708
name: isocitrate-homoisocitrate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reactions: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH, and (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD+ = 2-oxoadipate + CO2 + NADH + H+." [EC:1.1.1.286]
synonym: "homoisocitrate-isocitrate dehydrogenase activity" EXACT [EC:1.1.1.286]
synonym: "isocitrate(homoisocitrate):NAD+ oxidoreductase (decarboxylating) activity" EXACT [EC:1.1.1.286]
synonym: "PH1722" RELATED [EC:1.1.1.286]
xref: EC:1.1.1.286
xref: MetaCyc:RXN-7969
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033709
name: D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-arabinitol + NADP+ = D-ribulose + NADPH + H+." [EC:1.1.1.287]
synonym: "ARD1p" RELATED [EC:1.1.1.287]
synonym: "D-arabinitol dehydrogenase 1 activity" BROAD [EC:1.1.1.287]
synonym: "D-arabinitol:NADP+ dehydrogenase activity" BROAD [EC:1.1.1.287]
synonym: "NADP+-dependent D-arabinitol dehydrogenase activity" BROAD [EC:1.1.1.287]
xref: EC:1.1.1.-
xref: KEGG:R07144
xref: MetaCyc:RXN-7972
xref: RHEA:11871
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033711
name: 4-phosphoerythronate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-phospho-D-erythronate + NAD(+) = (R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + H(+) + NADH." [EC:1.1.1.290, RHEA:18832]
synonym: "4-O-phosphoerythronate dehydrogenase activity" EXACT [EC:1.1.1.290]
synonym: "4-phospho-D-erythronate:NAD+ 2-oxidoreductase activity" EXACT [EC:1.1.1.290]
synonym: "4PE dehydrogenase activity" EXACT [EC:1.1.1.290]
synonym: "erythronate-4-phosphate dehydrogenase activity" EXACT [EC:1.1.1.290]
synonym: "PdxB" RELATED [EC:1.1.1.290]
synonym: "PdxB 4PE dehydrogenase activity" EXACT [EC:1.1.1.290]
xref: EC:1.1.1.290
xref: KEGG:R04210
xref: MetaCyc:ERYTHRON4PDEHYDROG-RXN
xref: RHEA:18832
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033712
name: 1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,5-anhydro-D-mannitol + NADP(+) = 1,5-anhydro-D-fructose + H(+) + NADPH." [EC:1.1.1.292, RHEA:24211]
synonym: "1,5-anhydro-D-mannitol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.292]
synonym: "AFR" RELATED [EC:1.1.1.292]
xref: EC:1.1.1.292
xref: KEGG:R08194
xref: MetaCyc:1.1.1.292-RXN
xref: RHEA:24211
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033713
name: choline:oxygen 1-oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: choline + O2 = betaine aldehyde + hydrogen peroxide." [EC:1.1.3.17]
synonym: "choline oxidase activity" BROAD [EC:1.1.3.17]
xref: EC:1.1.3.17
xref: MetaCyc:CHOLINE-OXIDASE-RXN
xref: RHEA:24646
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0033714
name: secondary-alcohol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: O(2) + secondary alcohol = H(2)O(2) + ketone." [EC:1.1.3.18, RHEA:23183]
synonym: "polyvinyl alcohol oxidase activity" EXACT [EC:1.1.3.18]
synonym: "secondary alcohol oxidase activity" EXACT [EC:1.1.3.18]
synonym: "secondary-alcohol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.18]
xref: EC:1.1.3.18
xref: KEGG:R02277
xref: MetaCyc:SECONDARY-ALCOHOL-OXIDASE-RXN
xref: RHEA:23183
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0033715
name: nucleoside oxidase activity
namespace: molecular_function
def: "Catalysis of the reactions: inosine + O2 = 9-riburonosylhypoxanthine + 2 H2O; (1a) 2 inosine + O2 = 2 5'-dehydroinosine + 2 H2O, and (1b) 2 5'-dehydroinosine + O2 = 2 9-riburonosylhypoxanthine + 2 H2O." [EC:1.1.3.28]
synonym: "nucleoside:oxygen 5'-oxidoreductase activity" EXACT [EC:1.1.3.28]
xref: EC:1.1.3.28
xref: MetaCyc:NUCLEOSIDE-OXIDASE-RXN
xref: RHEA:24648
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0033716
name: nucleoside oxidase (hydrogen peroxide-forming) activity
namespace: molecular_function
def: "Catalysis of the reactions: adenosine + 2 O2 = 9-riburonosyladenine + 2 hydrogen peroxide; (1a) adenosine + O2 = 5'-dehydroadenosine + hydrogen peroxide, and (1b) 5'-dehydroadenosine + O2 = 9-riburonosyladenine + hydrogen peroxide." [EC:1.1.3.39]
synonym: "nucleoside:oxygen 5'-oxidoreductase (hydrogen peroxide-forming) activity" EXACT [EC:1.1.3.39]
xref: EC:1.1.3.39
xref: MetaCyc:1.1.3.39-RXN
xref: RHEA:24656
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0033717
name: gluconate 2-dehydrogenase (acceptor) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-gluconate + acceptor = 2-dehydro-D-gluconate + reduced acceptor." [EC:1.1.99.3]
synonym: "2-ketogluconate reductase activity" BROAD [EC:1.1.99.3]
synonym: "D-gluconate dehydrogenase activity" EXACT [EC:1.1.99.3]
synonym: "D-gluconate dehydrogenase, 2-keto-D-gluconate-yielding activity" EXACT [EC:1.1.99.3]
synonym: "D-gluconate:(acceptor) 2-oxidoreductase activity" EXACT [EC:1.1.99.3]
synonym: "D-gluconate:acceptor 2-oxidoreductase activity" EXACT [EC:1.1.99.3]
synonym: "gluconate oxidase activity" EXACT [EC:1.1.99.3]
synonym: "gluconic acid dehydrogenase activity" EXACT [EC:1.1.99.3]
synonym: "gluconic dehydrogenase activity" EXACT [EC:1.1.99.3]
xref: EC:1.1.99.3
xref: MetaCyc:GLUCONATE-2-DEHYDROGENASE-RXN
xref: RHEA:12772
is_a: GO:0008875 ! gluconate dehydrogenase activity

[Term]
id: GO:0033718
name: pyranose dehydrogenase (acceptor) activity
namespace: molecular_function
def: "Catalysis of the reactions: pyranose + acceptor = 2-dehydropyranose (or 3-dehydropyranose or 2,3-didehydropyranose) + reduced acceptor, and a pyranoside + acceptor = a 3-dehydropyranoside (or 3,4-didehydropyranoside) + reduced acceptor." [EC:1.1.99.29]
synonym: "PDH" RELATED [EC:1.1.99.29]
synonym: "pyranose dehydrogenase activity" EXACT [EC:1.1.99.29]
synonym: "pyranose-quinone oxidoreductase activity" EXACT [EC:1.1.99.29]
synonym: "pyranose:acceptor oxidoreductase activity" EXACT [EC:1.1.99.29]
synonym: "quinone-dependent pyranose dehydrogenase activity" EXACT [EC:1.1.99.29]
xref: EC:1.1.99.29
xref: MetaCyc:RXN-7961
xref: MetaCyc:RXN-7962
xref: MetaCyc:RXN-7963
xref: MetaCyc:RXN-7965
xref: MetaCyc:RXN-7966
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0033719
name: 2-oxo-acid reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: a (2R)-hydroxy-carboxylate + acceptor = a 2-oxo-carboxylate + reduced acceptor." [EC:1.1.99.30]
synonym: "(2R)-hydroxy-carboxylate:acceptor oxidoreductase activity" EXACT [EC:1.1.99.30]
synonym: "(2R)-hydroxycarboxylate-viologen-oxidoreductase activity" EXACT [EC:1.1.99.30]
synonym: "2-oxoacid reductase activity" EXACT [EC:1.1.99.30]
synonym: "HVOR" RELATED [EC:1.1.99.30]
xref: EC:1.1.99.30
xref: MetaCyc:1.1.99.30-RXN
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0033720
name: (S)-mandelate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-2-hydroxy-2-phenylacetate + acceptor = 2-oxo-2-phenylacetate + reduced acceptor." [EC:1.1.99.31]
synonym: "(S)-2-hydroxy-2-phenylacetate:acceptor 2-oxidoreductase activity" EXACT [EC:1.1.99.31]
synonym: "L(+)-mandelate dehydrogenase activity" EXACT [EC:1.1.99.31]
synonym: "MDH" RELATED [EC:1.1.99.31]
xref: EC:1.1.99.31
xref: MetaCyc:MANDELATE-DEHYDROGENASE-RXN
xref: MetaCyc:MANDELATE-OXY-RXN
xref: RHEA:15752
xref: UM-BBD_reactionID:r1048
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0033721
name: aldehyde dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: an aldehyde + NADP+ + H2O = an acid + NADPH + H+." [EC:1.2.1.4]
synonym: "aldehyde:NADP+ oxidoreductase activity" EXACT [EC:1.2.1.4]
synonym: "NADP-acetaldehyde dehydrogenase activity" EXACT [EC:1.2.1.4]
synonym: "NADP-dependent aldehyde dehydrogenase activity" EXACT [EC:1.2.1.4]
xref: EC:1.2.1.4
xref: MetaCyc:ALDEHYDE-DEHYDROGENASE-NADP+-RXN
xref: RHEA:11891
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033722
name: malonate-semialdehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-oxopropanoate + NAD(P)+ + H2O = malonate + NAD(P)H + H+." [EC:1.2.1.15]
synonym: "3-oxopropanoate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.2.1.15]
synonym: "malonic semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.15]
xref: EC:1.2.1.15
xref: MetaCyc:MALONATE-SEMIALDEHYDE-DEHYDROGENASE-RXN
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033723
name: fluoroacetaldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: fluoroacetaldehyde + NAD+ + H2O = fluoroacetate + NADH + 2 H+." [EC:1.2.1.69]
synonym: "fluoroacetaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.69]
xref: EC:1.2.1.69
xref: RHEA:16680
is_a: GO:0004029 ! aldehyde dehydrogenase (NAD) activity

[Term]
id: GO:0033726
name: aldehyde ferredoxin oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: an aldehyde + H2O + 2 oxidized ferredoxin = an acid + 2 H+ + 2 reduced ferredoxin." [EC:1.2.7.5]
synonym: "aldehyde:ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.5]
synonym: "AOR" RELATED [EC:1.2.7.5]
synonym: "tungsten-containing aldehyde ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.5]
xref: EC:1.2.7.5
xref: MetaCyc:1.2.7.5-RXN
is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0033727
name: aldehyde dehydrogenase (FAD-independent) activity
namespace: molecular_function
def: "Catalysis of the reaction: an aldehyde + H2O + acceptor = a carboxylate + reduced acceptor." [EC:1.2.99.7]
synonym: "aldehyde oxidoreductase activity" EXACT [EC:1.2.99.7]
synonym: "aldehyde:acceptor oxidoreductase (FAD-independent) activity" EXACT [EC:1.2.99.7]
synonym: "AORDd" RELATED [EC:1.2.99.7]
synonym: "Mop" RELATED [EC:1.2.99.7]
xref: EC:1.2.99.7
xref: MetaCyc:1.2.99.3-RXN
xref: MetaCyc:1.2.99.7-RXN
xref: MetaCyc:CARBOXYLATE-REDUCTASE-RXN
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0033728
name: divinyl chlorophyllide a 8-vinyl-reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: chlorophyllide a + NADP+ = divinyl chlorophyllide a + NADPH + H+." [EC:1.3.1.75]
synonym: "4VCR" RELATED [EC:1.3.1.75]
synonym: "[4-vinyl]chlorophyllide a reductase activity" EXACT [EC:1.3.1.75]
synonym: "chlorophyllide-a:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.75]
xref: EC:1.3.1.75
xref: MetaCyc:RXN-5286
xref: RHEA:14452
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033729
name: anthocyanidin reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: a flavan-3-ol + 2 NAD(P)+ = an anthocyanidin + 2 NAD(P)H + H+." [EC:1.3.1.77]
synonym: "ANR" RELATED [EC:1.3.1.77]
synonym: "AtANR" RELATED [EC:1.3.1.77]
synonym: "flavan-3-ol:NAD(P)+ oxidoreductase activity" EXACT [EC:1.3.1.77]
synonym: "MtANR" RELATED [EC:1.3.1.77]
xref: EC:1.3.1.77
xref: MetaCyc:1.3.1.77-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033730
name: arogenate dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arogenate + NADP+ = L-tyrosine + NADPH + CO2." [EC:1.3.1.78]
synonym: "arogenic dehydrogenase activity" BROAD [EC:1.3.1.78]
synonym: "L-arogenate:NADP+ oxidoreductase (decarboxylating) activity" EXACT [EC:1.3.1.78]
synonym: "pretyrosine dehydrogenase activity" BROAD [EC:1.3.1.78]
synonym: "TyrAa" RELATED [EC:1.3.1.78]
synonym: "TyrAAT1" RELATED [EC:1.3.1.78]
synonym: "TyrAAT2" RELATED [EC:1.3.1.78]
xref: EC:1.3.1.78
xref: MetaCyc:1.3.1.78-RXN
xref: RHEA:15420
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033731
name: arogenate dehydrogenase [NAD(P)+] activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arogenate + NAD(P)+ = L-tyrosine + NAD(P)H + CO2." [EC:1.3.1.79]
synonym: "arogenic dehydrogenase activity" BROAD [EC:1.3.1.79]
synonym: "L-arogenate:NAD(P)+ oxidoreductase (decarboxylating) activity" EXACT [EC:1.3.1.79]
synonym: "pretyrosine dehydrogenase activity" BROAD [EC:1.3.1.79]
xref: EC:1.3.1.79
xref: MetaCyc:1.3.1.79-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033732
name: pyrroloquinoline-quinone synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O(2) = 2 H(2)O + 2 H(2)O(2) + H(+) + pyrroloquinoline quinone." [EC:1.3.3.11, RHEA:10695]
synonym: "6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-2,4-dicarboxylate:oxygen oxidoreductase (cyclizing) activity" EXACT [EC:1.3.3.11]
synonym: "PqqC" RELATED [EC:1.3.3.11]
xref: EC:1.3.3.11
xref: KEGG:R07353
xref: MetaCyc:1.3.3.11-RXN
xref: RHEA:10695
is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor

[Term]
id: GO:0033734
name: (R)-benzylsuccinyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-2-benzylsuccinyl-CoA + 2 electron-transferring flavoprotein = (E)-2-benzylidenesuccinyl-CoA + 2 reduced electron-transferring flavoprotein." [EC:1.3.99.21]
synonym: "(R)-benzylsuccinyl-CoA:(acceptor) oxidoreductase activity" EXACT [EC:1.3.99.21]
synonym: "(R)-benzylsuccinyl-CoA:acceptor oxidoreductase activity" EXACT [EC:1.3.99.21]
synonym: "BbsG" RELATED [EC:1.3.99.21]
xref: EC:1.3.99.21
xref: UM-BBD_reactionID:r0330
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0033735
name: aspartate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H + H+." [EC:1.4.1.21]
synonym: "L-aspartate:NAD(P)+ oxidoreductase (deaminating) activity" EXACT [EC:1.4.1.21]
synonym: "NAD-dependent aspartate dehydrogenase activity" EXACT [EC:1.4.1.21]
synonym: "NADH2-dependent aspartate dehydrogenase activity" EXACT [EC:1.4.1.21]
synonym: "NADP+-dependent aspartate dehydrogenase activity" EXACT [EC:1.4.1.21]
xref: EC:1.4.1.21
xref: KEGG:R07164
xref: KEGG:R07165
xref: MetaCyc:1.4.1.21-RXN
xref: RHEA:11787
xref: RHEA:11791
is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors

[Term]
id: GO:0033736
name: L-lysine 6-oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-lysine + H(2)O + O(2) = allysine + H(2)O(2) + NH(4)(+)." [EC:1.4.3.20, RHEA:22551]
synonym: "L-lysine-epsilon-oxidase activity" EXACT [EC:1.4.3.20]
synonym: "L-lysine:oxygen 6-oxidoreductase (deaminating) activity" EXACT [EC:1.4.3.20]
synonym: "Lod" RELATED [EC:1.4.3.20]
synonym: "LodA" RELATED [EC:1.4.3.20]
synonym: "marinocine" RELATED [EC:1.4.3.20]
xref: EC:1.4.3.20
xref: KEGG:R07598
xref: MetaCyc:1.4.3.20-RXN
xref: RHEA:22551
is_a: GO:0001716 ! L-amino-acid oxidase activity

[Term]
id: GO:0033737
name: 1-pyrroline dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-pyrroline + NAD+ + 2 H2O = 4-aminobutanoate + NADH + 2 H+." [MetaCyc:1.5.1.35-RXN]
synonym: "1-pyrroline:NAD+ oxidoreductase activity" EXACT [EC:1.5.1.35]
synonym: "ABALDH" RELATED [EC:1.5.1.35]
synonym: "gamma-aminobutyraldehyde dehydrogenase activity" EXACT [EC:1.5.1.35]
synonym: "YdcW" RELATED [EC:1.5.1.35]
xref: EC:1.2.1.19
xref: MetaCyc:1.5.1.35-RXN
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0033738
name: methylenetetrahydrofolate reductase (ferredoxin) activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-methyltetrahydrofolate + oxidized ferredoxin = 5,10-methylenetetrahydrofolate + reduced ferredoxin." [EC:1.5.7.1]
synonym: "5,10-methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.7.1]
synonym: "5-methyltetrahydrofolate:ferredoxin oxidoreductase activity" EXACT [EC:1.5.7.1]
xref: EC:1.5.7.1
xref: MetaCyc:RXN-5061
is_a: GO:0033694 ! oxidoreductase activity, acting on the CH-NH group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0033739
name: preQ1 synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7-aminomethyl-7-deazaguanine + 2 NADP(+) = 7-cyano-7-deazaguanine + 3 H(+) + 2 NADPH." [EC:1.7.1.13, RHEA:13412]
synonym: "7-aminomethyl-7-carbaguanine:NADP+ oxidoreductase activity" EXACT systematic_synonym [EC:1.7.1.13]
synonym: "7-cyano-7-deazaguanine reductase activity" EXACT [EC:1.7.1.13]
synonym: "preQ0 oxidoreductase activity" EXACT [EC:1.7.1.13]
synonym: "preQ0 reductase activity" EXACT [EC:1.7.1.13]
synonym: "QueF" RELATED [EC:1.7.1.13]
synonym: "queuine synthase activity" RELATED []
synonym: "queuine:NADP+ oxidoreductase activity" RELATED []
synonym: "YkvM" RELATED [EC:1.7.1.13]
xref: EC:1.7.1.13
xref: KEGG:R07605
xref: MetaCyc:RXN0-4022
xref: RHEA:13412
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
is_a: GO:0016657 ! oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor

[Term]
id: GO:0033740
name: hydroxylamine oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reactions: hydroxylamine + NH3 = hydrazine + H2O, and hydrazine + acceptor = N2 + reduced acceptor." [EC:1.7.99.8]
synonym: "hydroxylamine:acceptor oxidoreductase activity" EXACT [EC:1.7.99.8]
xref: EC:1.7.99.8
xref: MetaCyc:1.7.99.8-RXN
xref: RHEA:23235
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033741
name: adenylyl-sulfate reductase (glutathione) activity
namespace: molecular_function
def: "Catalysis of the reaction: AMP + glutathione disulfide + H(+) + sulfite = 5'-adenylyl sulfate + 2 glutathione." [EC:1.8.4.9, RHEA:14144]
synonym: "5'-adenylylsulfate reductase activity" EXACT [EC:1.8.4.9]
synonym: "AMP,sulfite:glutathione-disulfide oxidoreductase (adenosine-5'-phosphosulfate-forming) activity" EXACT [EC:1.8.4.9]
synonym: "AMP,sulfite:oxidized-glutathione oxidoreductase (adenosine-5'-phosphosulfate-forming) activity" EXACT [EC:1.8.4.9]
synonym: "plant-type 5'-adenylylsulfate reductase activity" NARROW [EC:1.8.4.9]
xref: EC:1.8.4.9
xref: KEGG:R05717
xref: MetaCyc:1.8.4.9-RXN
xref: RHEA:14144
is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor

[Term]
id: GO:0033743
name: peptide-methionine (R)-S-oxide reductase activity
namespace: molecular_function
alt_id: GO:0000318
def: "Catalysis of the reaction: peptide-L-methionine + H(2)O + thioredoxin disulfide = peptide-L-methionine (R)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the R enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.8.4.12, GOC:mah, GOC:vw, RHEA:24167]
synonym: "methionine S-oxide reductase (R-form oxidizing) activity" EXACT [EC:1.8.4.12]
synonym: "methionine S-oxide reductase activity" BROAD [EC:1.8.4.12]
synonym: "methionine sulfoxide reductase activity" BROAD [EC:1.8.4.12]
synonym: "methionine sulfoxide reductase B activity" NARROW [EC:1.8.4.12]
synonym: "MsrB" RELATED [EC:1.8.4.12]
synonym: "peptide-methionine:thioredoxin-disulfide S-oxidoreductase [methionine (R)-S-oxide-forming] activity" EXACT [EC:1.8.4.12]
synonym: "PilB" RELATED [EC:1.8.4.12]
synonym: "pMRsr" RELATED [EC:1.8.4.12]
synonym: "pMSR" RELATED [EC:1.8.4.12]
synonym: "protein-methionine-R-oxide reductase activity" EXACT []
synonym: "selenoprotein R" RELATED [EC:1.8.4.12]
synonym: "SelR" RELATED [EC:1.8.4.12]
synonym: "SelX" RELATED [EC:1.8.4.12]
xref: EC:1.8.4.-
xref: EC:1.8.4.12
xref: KEGG:R07607
xref: MetaCyc:1.8.4.12-RXN
xref: RHEA:24167
is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor

[Term]
id: GO:0033744
name: L-methionine:thioredoxin-disulfide S-oxidoreductase activity
namespace: molecular_function
alt_id: GO:0000317
def: "Catalysis of the reaction: L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin." [EC:1.8.4.13]
synonym: "acetylmethionine sulfoxide reductase activity" EXACT [EC:1.8.4.13]
synonym: "free-methionine (S)-S-oxide reductase activity" EXACT [EC:1.8.4.13]
synonym: "fSMsr" RELATED [EC:1.8.4.13]
synonym: "L-methionine-(S)-S-oxide reductase activity" NARROW [GOC:bf, GOC:vw]
synonym: "L-methionine:oxidized-thioredoxin S-oxidoreductase activity" EXACT [EC:1.8.4.13]
synonym: "methionine sulfoxide reductase activity" BROAD [EC:1.8.4.13]
synonym: "methionine-S-oxide reductase activity" EXACT [PMID:11169920]
synonym: "methyl sulfoxide reductase I and II activity" EXACT [EC:1.8.4.13]
xref: EC:1.8.4.13
xref: KEGG:R07606
xref: MetaCyc:1.8.4.13-RXN
xref: RHEA:19996
is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor

[Term]
id: GO:0033745
name: L-methionine-(R)-S-oxide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-methionine + thioredoxin disulfide + H2O = L-methionine (R)-S-oxide + thioredoxin." [EC:1.8.4.14]
synonym: "free met-R-(o) reductase activity" EXACT [EC:1.8.4.14]
synonym: "free-methionine (R)-S-oxide reductase activity" EXACT [EC:1.8.4.14]
synonym: "FRMsr" RELATED [EC:1.8.4.14]
synonym: "L-methionine:thioredoxin-disulfide S-oxidoreductase [L-methionine (R)-S-oxide-forming] activity" EXACT [EC:1.8.4.14]
xref: EC:1.8.4.14
xref: MetaCyc:1.8.4.14-RXN
xref: RHEA:21263
is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor

[Term]
id: GO:0033746
name: histone demethylase activity (H3-R2 specific)
namespace: molecular_function
def: "Catalysis of the removal of a methyl group from arginine at position 2 of the histone H3 protein." [GOC:mah]
is_a: GO:0032452 ! histone demethylase activity
relationship: part_of GO:0070078 ! histone H3-R2 demethylation

[Term]
id: GO:0033747
name: obsolete versatile peroxidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reactions: Reactive Black 5 + hydrogen peroxide = oxidized Reactive Black 5 + 2 H2O, and donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.16]
synonym: "hybrid peroxidase activity" EXACT [EC:1.11.1.16]
synonym: "polyvalent peroxidase activity" EXACT [EC:1.11.1.16]
synonym: "reactive-black-5:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.16]
synonym: "versatile peroxidase activity" EXACT []
synonym: "VP" RELATED [EC:1.11.1.16]
is_obsolete: true
replaced_by: GO:0004601
consider: GO:0052750

[Term]
id: GO:0033748
name: hydrogenase (acceptor) activity
namespace: molecular_function
def: "Catalysis of the reaction: H2 + A = AH2." [EC:1.12.99.6]
synonym: "H2 producing hydrogenase activity" BROAD [EC:1.12.99.6]
synonym: "hydrogen-lyase activity" BROAD [EC:1.12.99.6]
synonym: "hydrogen:(acceptor) oxidoreductase activity" EXACT [EC:1.12.99.6]
synonym: "hydrogen:acceptor oxidoreductase activity" EXACT [EC:1.12.99.6]
synonym: "hydrogenlyase activity" BROAD [EC:1.12.99.6]
synonym: "uptake hydrogenase activity" BROAD [EC:1.12.99.6]
xref: EC:1.12.99.6
xref: MetaCyc:RXN0-4141
xref: MetaCyc:RXN0-5256
xref: RHEA:12119
is_a: GO:0016695 ! oxidoreductase activity, acting on hydrogen as donor

[Term]
id: GO:0033749
name: histone demethylase activity (H4-R3 specific)
namespace: molecular_function
def: "Catalysis of the removal of a methyl group from arginine at position 3 of the histone H4 protein." [GOC:mah]
is_a: GO:0032452 ! histone demethylase activity
relationship: part_of GO:0070079 ! histone H4-R3 demethylation

[Term]
id: GO:0033750
name: ribosome localization
namespace: biological_process
def: "A process in which a ribosome is transported to, and/or maintained in, a specific location." [GOC:mah]
synonym: "ribosome localisation" EXACT []
is_a: GO:0051640 ! organelle localization

[Term]
id: GO:0033751
name: linoleate diol synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: linoleate + O2 = (9Z,12Z)-(7S,8S)-dihydroxyoctadeca-9,12-dienoate." [EC:1.13.11.44]
comment: Please note that this term is slated for obsoletion as part of the EC mapping updates.
subset: mf_needs_review
synonym: "linoleate (8R)-dioxygenase activity" EXACT [EC:1.13.11.44]
synonym: "linoleate 8-dioxygenase activity" EXACT [EC:1.13.11.44]
synonym: "linoleate:oxygen 7S,8S-oxidoreductase activity" EXACT [EC:1.13.11.44]
xref: EC:1.13.11.44
xref: MetaCyc:1.13.11.44-RXN
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0033752
name: acetylacetone-cleaving enzyme activity
namespace: molecular_function
def: "Catalysis of the reaction: pentane-2,4-dione + O2 = acetate + 2-oxopropanal." [EC:1.13.11.50]
synonym: "acetylacetone dioxygenase activity" EXACT [EC:1.13.11.50]
synonym: "acetylacetone-cleaving enzyme" RELATED [EC:1.13.11.50]
synonym: "acetylacetone:oxygen oxidoreductase activity" EXACT [EC:1.13.11.50]
synonym: "diketone cleaving dioxygenase activity" EXACT [EC:1.13.11.50]
synonym: "diketone cleaving enzyme" RELATED [EC:1.13.11.50]
synonym: "Dke1" RELATED [EC:1.13.11.50]
xref: EC:1.13.11.50
xref: RHEA:12880
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0033753
name: establishment of ribosome localization
namespace: biological_process
def: "The directed movement of the ribosome to a specific location." [GOC:mah]
synonym: "establishment of ribosome localisation" EXACT []
is_a: GO:0033750 ! ribosome localization
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0051656 ! establishment of organelle localization

[Term]
id: GO:0033754
name: indoleamine 2,3-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: tryptophan + O2 = N-formylkynurenine. The product of the reaction depends on the substrate; D-tryptophan produces N-formyl-D-kynurenine, and L-tryptophan produces N-formyl-L-kynurenine." [EC:1.13.11.52]
synonym: "D-tryptophan:oxygen 2,3-oxidoreductase (decyclizing) activity" NARROW [EC:1.13.11.52]
synonym: "IDO" RELATED [EC:1.13.11.52]
synonym: "tryptophan pyrrolase activity" BROAD [EC:1.13.11.52]
xref: EC:1.13.11.52
xref: MetaCyc:RXN-8664
xref: MetaCyc:RXN-8665
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0033755
name: sulfur oxygenase/reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4 sulfur + 4 H2O + O2 = 2 hydrogen sulfide + 2 bisulfite + 2 H+." [EC:1.13.11.55]
synonym: "SOR" RELATED [EC:1.13.11.55]
synonym: "sulfur oxygenase activity" BROAD [EC:1.13.11.55]
synonym: "sulfur:oxygen oxidoreductase (hydrogen-sulfide- and sulfite-forming) activity" EXACT [EC:1.13.11.55]
synonym: "sulphur oxygenase/reductase activity" EXACT []
xref: EC:1.13.11.55
xref: MetaCyc:1.13.11.55-RXN
xref: RHEA:13960
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0033756
name: Oplophorus-luciferin 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: Oplophorus luciferin + O2 = oxidized Oplophorus luciferin + CO2 + hnu." [EC:1.13.12.13]
synonym: "Oplophorus luciferase activity" EXACT [EC:1.13.12.13]
synonym: "Oplophorus-luciferin:oxygen 2-oxidoreductase (decarboxylating) activity" EXACT [EC:1.13.12.13]
xref: EC:1.13.12.13
xref: MetaCyc:RXN-3361
xref: RHEA:20420
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)
is_a: GO:0045289 ! luciferin monooxygenase activity

[Term]
id: GO:0033757
name: glucoside 3-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: sucrose + acceptor = 3-dehydro-alpha-D-glucosyl-beta-D-fructofuranoside + reduced acceptor." [EC:1.1.99.13]
synonym: "D-aldohexopyranoside dehydrogenase" EXACT [EC:1.1.99.13]
synonym: "D-aldohexoside:(acceptor) 3-oxidoreductase" EXACT [EC:1.1.99.13]
synonym: "D-aldohexoside:acceptor 3-oxidoreductase" EXACT [EC:1.1.99.13]
synonym: "D-aldohexoside:cytochrome c oxidoreductase" EXACT [EC:1.1.99.13]
synonym: "hexopyranoside-cytochrome c oxidoreductase" EXACT [EC:1.1.99.13]
xref: EC:1.1.99.13
xref: MetaCyc:GLUCOSIDE-3-DEHYDROGENASE-RXN
xref: RHEA:16592
xref: Wikipedia:Glucoside_3-dehydrogenase
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0033758
name: clavaminate synthase activity
namespace: molecular_function
def: "Catalysis of the reactions: deoxyamidinoproclavaminate + 2-oxoglutarate + O2 = amidinoproclavaminate + succinate + CO2 + H2O; proclavaminate + 2-oxoglutarate + O2 = dihydroclavaminate + succinate + CO2 + 2 H2O; and dihydroclavaminate + 2-oxoglutarate + O2 = clavaminate + succinate + CO2 + 2 H2O." [EC:1.14.11.21]
subset: mf_needs_review
synonym: "clavaminate synthase 2 activity" NARROW [EC:1.14.11.21]
synonym: "clavaminic acid synthase activity" EXACT [EC:1.14.11.21]
synonym: "deoxyamidinoproclavaminate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.11.21]
xref: EC:1.14.11.21
xref: MetaCyc:1.14.11.21-RXN
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0033759
name: flavone synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: a flavanone + 2-oxoglutarate + O2 = a flavone + succinate + CO2 + H2O." [EC:1.14.11.22]
synonym: "flavanone,2-oxoglutarate:oxygen oxidoreductase (dehydrating) activity" EXACT [EC:1.14.11.22]
synonym: "flavone synthase I activity" EXACT [EC:1.14.11.22]
synonym: "FNS I" RELATED [EC:1.14.11.22]
xref: EC:1.14.11.22
xref: MetaCyc:RXN-8000
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
relationship: part_of GO:0051553 ! flavone biosynthetic process

[Term]
id: GO:0033760
name: 2'-deoxymugineic-acid 2'-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2'-deoxymugineate + 2-oxoglutarate + O(2) = CO(2) + H(+) + mugineate + succinate." [EC:1.14.11.24, RHEA:12203]
synonym: "2'-deoxymugineic acid,2-oxoglutarate:oxygen oxidoreductase (2-hydroxylating) activity" EXACT [EC:1.14.11.24]
synonym: "IDS3" RELATED [EC:1.14.11.24]
xref: EC:1.14.11.24
xref: KEGG:R07185
xref: MetaCyc:1.14.11.24-RXN
xref: RHEA:12203
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0033761
name: mugineic-acid 3-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reactions: mugineic acid + 2-oxoglutarate + O2 = 3-epihydroxymugineic acid + succinate + CO2." [EC:1.14.11.25]
synonym: "IDS2" RELATED [EC:1.14.11.25]
synonym: "mugineic acid,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.11.25]
xref: EC:1.14.11.25
xref: KEGG:R07186
xref: MetaCyc:RXN-7982
xref: RHEA:14512
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0033762
name: response to glucagon
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus." [GOC:sl]
synonym: "response to glucagon stimulus" EXACT [GOC:dos]
is_a: GO:0043434 ! response to peptide hormone

[Term]
id: GO:0033763
name: proline 3-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-proline + 2-oxoglutarate + O2 = cis-3-hydroxy-L-proline + succinate + CO2." [EC:1.14.11.28]
synonym: "L-proline,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.11.28]
synonym: "P-3-H" RELATED [EC:1.14.11.28]
xref: EC:1.14.11.28
xref: MetaCyc:1.14.11.28-RXN
xref: RHEA:20268
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0033764
name: steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP, and in which one substrate is a sterol derivative." [GOC:mah]
subset: gosubset_prok
xref: EC:1.1.1.-
is_a: GO:0016229 ! steroid dehydrogenase activity
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033765
name: steroid dehydrogenase activity, acting on the CH-CH group of donors
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor, and in which one substrate is a sterol derivative." [GOC:mah]
subset: gosubset_prok
xref: EC:1.1.1.-
is_a: GO:0016229 ! steroid dehydrogenase activity
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0033766
name: 2-hydroxyquinoline 8-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(+) + NADH + O(2) + quinolin-2-ol = H(2)O + NAD(+) + quinoline-2,8-diol." [EC:1.14.13.61, RHEA:22083]
synonym: "2-oxo-1,2-dihydroquinoline 8-monooxygenase activity" EXACT [EC:1.14.13.61]
synonym: "quinolin-2(1H)-one,NADH:oxygen oxidoreductase (8-oxygenating) activity" EXACT [EC:1.14.13.61]
xref: EC:1.14.13.61
xref: KEGG:R05158
xref: MetaCyc:1.14.13.61-RXN
xref: RHEA:22083
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0033767
name: 4-hydroxyacetophenone monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4'-hydroxyacetophenone + H(+) + NADPH + O(2) = 4-hydroxyphenyl acetate + H(2)O + NADP(+)." [EC:1.14.13.84, RHEA:22919]
synonym: "(4-hydroxyphenyl)ethan-1-one,NADPH:oxygen oxidoreductase (ester-forming) activity" EXACT systematic_synonym [EC:1.14.13.84]
synonym: "HAPMO" RELATED [EC:1.14.13.84]
xref: EC:1.14.13.84
xref: KEGG:R06892
xref: MetaCyc:1.14.13.84-RXN
xref: RHEA:22919
xref: UM-BBD_reactionID:r0756
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0033768
name: SUMO-targeted ubiquitin ligase complex
namespace: cellular_component
def: "A nuclear ubiquitin ligase complex that specifically targets SUMOylated proteins; the complex is formed of homodimers or heterodimers of RNF4 family ubiquitin ligases and is conserved in eukaryotes." [GOC:vw, PMID:17762864, PMID:17762865]
is_a: GO:0000152 ! nuclear ubiquitin ligase complex

[Term]
id: GO:0033769
name: glyceollin synthase activity
namespace: molecular_function
def: "Catalysis of the reactions: 2-dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan + NADPH + H+ + O2 = glyceollin + NADP+ + 2 H2O, and 4-dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan + NADPH + H+ + O2 = glyceollin + NADP+ + 2 H2O." [EC:1.14.13.85]
synonym: "2-(or 4-)dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan,NADPH:oxygen oxidoreductase (cyclizing) activity" EXACT [EC:1.14.13.85]
synonym: "dimethylallyl-3,6a,9-trihydroxypterocarpan cyclase activity" EXACT [EC:1.14.13.85]
xref: EC:1.14.13.85
xref: MetaCyc:2.5.1.36-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0033770
name: 2-hydroxyisoflavanone synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: apigenin + 2 NADPH + 2 H+ + O2 = 2-hydroxy-2,3-dihydrogenistein + 2 NADP+ + H2O." [EC:1.14.13.86]
synonym: "2-HIS" RELATED [EC:1.14.13.86]
synonym: "apigenin,NADPH:oxygen oxidoreductase (isoflavanone-forming) activity" EXACT [EC:1.14.13.86]
xref: EC:1.14.13.86
xref: MetaCyc:RXN-7750
xref: RHEA:14900
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0033771
name: licodione synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(+) + liquiritigenin + NADPH + O(2) = H(2)O + licodione + NADP(+)." [EC:1.14.13.87, RHEA:15700]
synonym: "(2S)-flavanone 2-hydroxylase activity" EXACT [EC:1.14.13.87]
synonym: "liquiritigenin,NADPH:oxygen oxidoreductase (licodione-forming) activity" EXACT [EC:1.14.13.87]
xref: EC:1.14.13.87
xref: KEGG:R07198
xref: MetaCyc:1.14.13.87-RXN
xref: RHEA:15700
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0033772
name: flavonoid 3',5'-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reactions: a flavanone + NADPH + H+ + O2 = a 3'-hydroxyflavanone + NADP+ + H2O, and a 3'-hydroxyflavanone + NADPH + H+ + O2 = a 3',5'-dihydroxyflavanone + NADP+ + H2O." [EC:1.14.13.88]
synonym: "F3',5'H" RELATED [EC:1.14.13.88]
synonym: "F3'5'H" RELATED [EC:1.14.13.88]
synonym: "flavanone,NADPH:oxygen oxidoreductase activity" EXACT [EC:1.14.13.88]
xref: EC:1.14.13.88
xref: MetaCyc:RXN-7783
xref: MetaCyc:RXN-8671
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0033773
name: isoflavone 2'-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: an isoflavone + NADPH + H+ + O2 = a 2'-hydroxyisoflavone + NADP+ + H2O." [EC:1.14.13.89]
synonym: "CYP Ge-3" RELATED [EC:1.14.13.89]
synonym: "CYP81E1" RELATED [EC:1.14.13.89]
synonym: "isoflavone 2'-monooxygenase activity" BROAD [EC:1.14.13.89]
synonym: "isoflavone,NADPH:oxygen oxidoreductase (2'-hydroxylating) activity" EXACT [EC:1.14.13.89]
xref: EC:1.14.13.89
xref: MetaCyc:ISOFLAVONE-2-HYDROXYLASE-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0033774
name: basal labyrinth
namespace: cellular_component
def: "A region in the lower half of some cells formed from extensive infoldings of the basal plasma membrane; includes cytoplasm adjacent to the infolded membrane." [GOC:mah, GOC:sart, PMID:11640882]
is_a: GO:0044464 ! cell part
relationship: part_of GO:0045178 ! basal part of cell

[Term]
id: GO:0033775
name: deoxysarpagine hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 10-deoxysarpagine + H(+) + NADPH + O(2) = H(2)O + NADP(+) + sarpagine." [EC:1.14.13.91, RHEA:14240]
synonym: "10-deoxysarpagine,NADPH:oxygen oxidoreductase (10-hydroxylating) activity" EXACT [EC:1.14.13.91]
synonym: "DOSH" RELATED [EC:1.14.13.91]
xref: EC:1.14.13.91
xref: KEGG:R05828
xref: MetaCyc:1.14.13.91-RXN
xref: RHEA:14240
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0033776
name: phenylacetone monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(+) + NADPH + O(2) + phenylacetone = benzyl acetate + H(2)O + NADP(+)." [EC:1.14.13.92, RHEA:10127]
synonym: "PAMO" RELATED [EC:1.14.13.92]
synonym: "phenylacetone,NADPH:oxygen oxidoreductase activity" EXACT [EC:1.14.13.92]
xref: EC:1.14.13.92
xref: KEGG:R07201
xref: MetaCyc:1.14.13.92-RXN
xref: RHEA:10127
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0033777
name: lithocholate 6beta-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(+) + lithocholate + NADPH + O(2) = 6-beta-hydroxylithocholate + H(2)O + NADP(+)." [EC:1.14.13.94, RHEA:18860]
synonym: "6beta-hydroxylase activity" BROAD [EC:1.14.13.94]
synonym: "CYP3A10" RELATED [EC:1.14.13.94]
synonym: "cytochrome P450 3A10/lithocholic acid 6beta-hydroxylase activity" EXACT [EC:1.14.13.94]
synonym: "lithocholate 6beta-monooxygenase activity" EXACT [EC:1.14.13.94]
synonym: "lithocholate,NADPH:oxygen oxidoreductase (6beta-hydroxylating) activity" EXACT [EC:1.14.13.94]
xref: EC:1.14.13.94
xref: KEGG:R07203
xref: MetaCyc:1.14.13.94-RXN
xref: RHEA:18860
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0033778
name: 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7alpha-hydroxycholest-4-en-3-one + H(+) + NADPH + O(2) = 7alpha,12alpha-dihydroxycholest-4-en-3-one + H(2)O + NADP(+)." [EC:1.14.13.95, RHEA:10507]
synonym: "7alpha-hydroxy-4-cholesten-3-one 12alpha-monooxygenase activity" EXACT [EC:1.14.13.95]
synonym: "7alpha-hydroxycholest-4-en-3-one,NADPH:oxygen oxidoreductase (12alpha-hydroxylating) activity" EXACT [EC:1.14.13.95]
synonym: "CYP12" RELATED [EC:1.14.13.95]
synonym: "HCO 12alpha-hydroxylase activity" EXACT [EC:1.14.13.95]
synonym: "sterol 12alpha-hydroxylase activity" BROAD [EC:1.14.13.95]
xref: EC:1.14.13.95
xref: KEGG:R04826
xref: MetaCyc:1.14.13.95-RXN
xref: Reactome:REACT_10016 "4-Cholesten-7alpha,24(S)-diol-3-one is 12alpha-hydroxylated to 4-cholesten-7-alpha,12-alpha,24(S)-triol-3-one, Homo sapiens"
xref: Reactome:REACT_10028 "4-Cholesten-7alpha,27-diol-3-one is 12alpha-hydroxylated to 4-Cholesten-7alpha,12alpha,27-triol-3-one, Homo sapiens"
xref: Reactome:REACT_10071 "4-Cholesten-7alpha-ol-3-one is 12alpha-hydroxylated to 7-alpha,12-alpha-dihydroxycholest-4-en-3-one, Homo sapiens"
xref: Reactome:REACT_101155 "4-Cholesten-7alpha,27-diol-3-one is 12alpha-hydroxylated to 4-Cholesten-7alpha,12alpha,27-triol-3-one, Canis familiaris"
xref: Reactome:REACT_102486 "4-Cholesten-7alpha-ol-3-one is 12alpha-hydroxylated to 7-alpha,12-alpha-dihydroxycholest-4-en-3-one, Rattus norvegicus"
xref: Reactome:REACT_103388 "4-Cholesten-7alpha-ol-3-one is 12alpha-hydroxylated to 7-alpha,12-alpha-dihydroxycholest-4-en-3-one, Xenopus tropicalis"
xref: Reactome:REACT_106615 "4-Cholesten-7alpha,27-diol-3-one is 12alpha-hydroxylated to 4-Cholesten-7alpha,12alpha,27-triol-3-one, Rattus norvegicus"
xref: Reactome:REACT_107159 "4-Cholesten-7alpha,27-diol-3-one is 12alpha-hydroxylated to 4-Cholesten-7alpha,12alpha,27-triol-3-one, Bos taurus"
xref: Reactome:REACT_110150 "4-Cholesten-7alpha-ol-3-one is 12alpha-hydroxylated to 7-alpha,12-alpha-dihydroxycholest-4-en-3-one, Bos taurus"
xref: Reactome:REACT_112283 "4-Cholesten-7alpha,27-diol-3-one is 12alpha-hydroxylated to 4-Cholesten-7alpha,12alpha,27-triol-3-one, Dictyostelium discoideum"
xref: Reactome:REACT_113628 "4-Cholesten-7alpha-ol-3-one is 12alpha-hydroxylated to 7-alpha,12-alpha-dihydroxycholest-4-en-3-one, Arabidopsis thaliana"
xref: Reactome:REACT_114278 "4-Cholesten-7alpha,24(S)-diol-3-one is 12alpha-hydroxylated to 4-cholesten-7-alpha,12-alpha,24(S)-triol-3-one, Arabidopsis thaliana"
xref: Reactome:REACT_114416 "4-Cholesten-7alpha-ol-3-one is 12alpha-hydroxylated to 7-alpha,12-alpha-dihydroxycholest-4-en-3-one, Oryza sativa"
xref: Reactome:REACT_114504 "4-Cholesten-7alpha,24(S)-diol-3-one is 12alpha-hydroxylated to 4-cholesten-7-alpha,12-alpha,24(S)-triol-3-one, Dictyostelium discoideum"
xref: Reactome:REACT_114554 "4-Cholesten-7alpha,27-diol-3-one is 12alpha-hydroxylated to 4-Cholesten-7alpha,12alpha,27-triol-3-one, Oryza sativa"
xref: Reactome:REACT_114957 "4-Cholesten-7alpha,24(S)-diol-3-one is 12alpha-hydroxylated to 4-cholesten-7-alpha,12-alpha,24(S)-triol-3-one, Mycobacterium tuberculosis"
xref: Reactome:REACT_115001 "4-Cholesten-7alpha-ol-3-one is 12alpha-hydroxylated to 7-alpha,12-alpha-dihydroxycholest-4-en-3-one, Mycobacterium tuberculosis"
xref: Reactome:REACT_115030 "4-Cholesten-7alpha-ol-3-one is 12alpha-hydroxylated to 7-alpha,12-alpha-dihydroxycholest-4-en-3-one, Dictyostelium discoideum"
xref: Reactome:REACT_115216 "4-Cholesten-7alpha,27-diol-3-one is 12alpha-hydroxylated to 4-Cholesten-7alpha,12alpha,27-triol-3-one, Arabidopsis thaliana"
xref: Reactome:REACT_115313 "4-Cholesten-7alpha,24(S)-diol-3-one is 12alpha-hydroxylated to 4-cholesten-7-alpha,12-alpha,24(S)-triol-3-one, Oryza sativa"
xref: Reactome:REACT_30306 "4-Cholesten-7alpha-ol-3-one is 12alpha-hydroxylated to 7-alpha,12-alpha-dihydroxycholest-4-en-3-one, Canis familiaris"
xref: Reactome:REACT_34765 "4-Cholesten-7alpha-ol-3-one is 12alpha-hydroxylated to 7-alpha,12-alpha-dihydroxycholest-4-en-3-one, Mus musculus"
xref: Reactome:REACT_79540 "4-Cholesten-7alpha-ol-3-one is 12alpha-hydroxylated to 7-alpha,12-alpha-dihydroxycholest-4-en-3-one, Taeniopygia guttata"
xref: Reactome:REACT_79551 "4-Cholesten-7alpha,24(S)-diol-3-one is 12alpha-hydroxylated to 4-cholesten-7-alpha,12-alpha,24(S)-triol-3-one, Rattus norvegicus"
xref: Reactome:REACT_79575 "4-Cholesten-7alpha,24(S)-diol-3-one is 12alpha-hydroxylated to 4-cholesten-7-alpha,12-alpha,24(S)-triol-3-one, Canis familiaris"
xref: Reactome:REACT_80434 "4-Cholesten-7alpha,27-diol-3-one is 12alpha-hydroxylated to 4-Cholesten-7alpha,12alpha,27-triol-3-one, Danio rerio"
xref: Reactome:REACT_84548 "4-Cholesten-7alpha,24(S)-diol-3-one is 12alpha-hydroxylated to 4-cholesten-7-alpha,12-alpha,24(S)-triol-3-one, Danio rerio"
xref: Reactome:REACT_88158 "4-Cholesten-7alpha,27-diol-3-one is 12alpha-hydroxylated to 4-Cholesten-7alpha,12alpha,27-triol-3-one, Xenopus tropicalis"
xref: Reactome:REACT_90466 "4-Cholesten-7alpha,24(S)-diol-3-one is 12alpha-hydroxylated to 4-cholesten-7-alpha,12-alpha,24(S)-triol-3-one, Mus musculus"
xref: Reactome:REACT_92496 "4-Cholesten-7alpha,24(S)-diol-3-one is 12alpha-hydroxylated to 4-cholesten-7-alpha,12-alpha,24(S)-triol-3-one, Xenopus tropicalis"
xref: Reactome:REACT_92610 "4-Cholesten-7alpha-ol-3-one is 12alpha-hydroxylated to 7-alpha,12-alpha-dihydroxycholest-4-en-3-one, Danio rerio"
xref: Reactome:REACT_93852 "4-Cholesten-7alpha,24(S)-diol-3-one is 12alpha-hydroxylated to 4-cholesten-7-alpha,12-alpha,24(S)-triol-3-one, Taeniopygia guttata"
xref: Reactome:REACT_94412 "4-Cholesten-7alpha,27-diol-3-one is 12alpha-hydroxylated to 4-Cholesten-7alpha,12alpha,27-triol-3-one, Mus musculus"
xref: Reactome:REACT_99087 "4-Cholesten-7alpha,27-diol-3-one is 12alpha-hydroxylated to 4-Cholesten-7alpha,12alpha,27-triol-3-one, Taeniopygia guttata"
xref: Reactome:REACT_99746 "4-Cholesten-7alpha,24(S)-diol-3-one is 12alpha-hydroxylated to 4-cholesten-7-alpha,12-alpha,24(S)-triol-3-one, Bos taurus"
xref: RHEA:10507
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0033779
name: 5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5beta-cholestane-3alpha,7alpha-diol + H(+) + NADPH + O(2) = 5beta-cholestane-3alpha,7alpha,12alpha-triol + H(2)O + NADP(+)." [EC:1.14.13.96, RHEA:15264]
synonym: "5beta-cholestane-3alpha,7alpha-diol 12alpha-monooxygenase activity" EXACT [EC:1.14.13.96]
synonym: "5beta-cholestane-3alpha,7alpha-diol,NADPH:oxygen oxidoreductase (12alpha-hydroxylating) activity" EXACT [EC:1.14.13.96]
synonym: "CYP8B1" RELATED [EC:1.14.13.96]
synonym: "cytochrome P450 8B1" RELATED [EC:1.14.13.96]
synonym: "sterol 12alpha-hydroxylase activity" BROAD [EC:1.14.13.96]
xref: EC:1.14.13.96
xref: KEGG:R07204
xref: MetaCyc:1.14.13.96-RXN
xref: RHEA:15264
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0033780
name: taurochenodeoxycholate 6alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reactions: taurochenodeoxycholate + NADPH + H+ + O2 = taurohyocholate + NADP+ + H2O, and lithocholate + NADPH + H+ + O2 = hyodeoxycholate + NADP+ + H2O." [EC:1.14.13.97]
synonym: "CYP3A4" RELATED [EC:1.14.13.97]
synonym: "CYP4A21" RELATED [EC:1.14.13.97]
synonym: "taurochenodeoxycholate 6alpha-monooxygenase activity" EXACT [EC:1.14.13.97]
synonym: "taurochenodeoxycholate,NADPH:oxygen oxidoreductase (6alpha-hydroxylating) activity" EXACT [EC:1.14.13.97]
xref: EC:1.14.13.97
xref: MetaCyc:RXN-7977
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0033781
name: cholesterol 24-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: cholesterol + H(+) + NADPH + O(2) = (24S)-24-hydroxycholesterol + H(2)O + NADP(+)." [EC:1.14.13.98, RHEA:22719]
synonym: "cholesterol 24-monooxygenase activity" EXACT [EC:1.14.13.98]
synonym: "cholesterol 24S-hydroxylase activity" EXACT [EC:1.14.13.98]
synonym: "cholesterol,NADPH:oxygen oxidoreductase (24-hydroxylating) activity" EXACT [EC:1.14.13.98]
synonym: "CYP46" RELATED [EC:1.14.13.98]
synonym: "CYP46A1" RELATED [EC:1.14.13.98]
synonym: "cytochrome P450 46A1" RELATED [EC:1.14.13.98]
xref: EC:1.14.13.98
xref: KEGG:R07207
xref: MetaCyc:1.14.13.98-RXN
xref: Reactome:REACT_100868 "Cholesterol is hydroxylated to 24-hydroxycholesterol by CYP46A1, Xenopus tropicalis"
xref: Reactome:REACT_10129 "Cholesterol is hydroxylated to 24-hydroxycholesterol by CYP46A1, Homo sapiens"
xref: Reactome:REACT_102867 "Cholesterol is hydroxylated to 24-hydroxycholesterol by CYP46A1, Sus scrofa"
xref: Reactome:REACT_78490 "Cholesterol is hydroxylated to 24-hydroxycholesterol by CYP46A1, Mus musculus"
xref: Reactome:REACT_79067 "Cholesterol is hydroxylated to 24-hydroxycholesterol by CYP46A1, Taeniopygia guttata"
xref: Reactome:REACT_79090 "Cholesterol is hydroxylated to 24-hydroxycholesterol by CYP46A1, Gallus gallus"
xref: Reactome:REACT_79585 "Cholesterol is hydroxylated to 24-hydroxycholesterol by CYP46A1, Canis familiaris"
xref: Reactome:REACT_83550 "Cholesterol is hydroxylated to 24-hydroxycholesterol by CYP46A1, Rattus norvegicus"
xref: Reactome:REACT_94780 "Cholesterol is hydroxylated to 24-hydroxycholesterol by CYP46A1, Bos taurus"
xref: RHEA:22719
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0033782
name: 24-hydroxycholesterol 7alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: (24R)-cholest-5-ene-3beta,24-diol + H(+) + NADPH + O(2) = (24R)-7alpha,24-dihydroxycholesterol + H(2)O + NADP(+)." [EC:1.14.13.99, RHEA:16096]
synonym: "(24R)-cholest-5-ene-3beta,24-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating) activity" EXACT [EC:1.14.13.99]
synonym: "24-hydroxycholesterol 7alpha-monooxygenase activity" EXACT [EC:1.14.13.99]
synonym: "CYP39A1" RELATED [EC:1.14.13.99]
synonym: "CYP39A1 oxysterol 7alpha-hydroxylase activity" EXACT [EC:1.14.13.99]
xref: EC:1.14.13.99
xref: KEGG:R07208
xref: MetaCyc:1.14.13.99-RXN
xref: RHEA:16096
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0033783
name: 25-hydroxycholesterol 7alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reactions: cholest-5-ene-3beta,25-diol + NADPH + H+ + O2 = cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O, and cholest-5-ene-3beta,27-diol + NADPH + H+ + O2 = cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O." [EC:1.14.13.100]
synonym: "25-hydroxycholesterol 7alpha-monooxygenase activity" EXACT [EC:1.14.13.100]
synonym: "cholest-5-ene-3beta,25-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating) activity" EXACT [EC:1.14.13.100]
synonym: "CYP7B1" RELATED [EC:1.14.13.100]
synonym: "CYP7B1 oxysterol 7alpha-hydroxylase activity" EXACT [EC:1.14.13.100]
xref: EC:1.14.13.100
xref: MetaCyc:RXN-7980
xref: MetaCyc:RXN-7981
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0033784
name: senecionine N-oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(+) + NADPH + O(2) + senecionine = H(2)O + NADP(+) + senecionine N-oxide." [EC:1.14.13.101, RHEA:11423]
synonym: "senecionine monooxygenase (N-oxide-forming) activity" EXACT [EC:1.14.13.101]
synonym: "senecionine,NADPH:oxygen oxidoreductase (N-oxide-forming) activity" EXACT [EC:1.14.13.101]
synonym: "SNO" RELATED [EC:1.14.13.101]
xref: EC:1.14.13.101
xref: KEGG:R07373
xref: MetaCyc:1.14.13.101-RXN
xref: RHEA:11423
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0033785
name: heptose 7-phosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-alpha,beta-D-heptose-7-phosphate + ATP = D-beta-D-heptose-1,7-bisphosphate + ADP." [MetaCyc:RXN0-4341]
subset: gosubset_prok
synonym: "D-alpha,beta-D-heptose 7-phosphate 1-kinase activity" EXACT []
xref: EC:2.7.1.-
xref: IMG:02784
xref: MetaCyc:RXN0-4341
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0033786
name: heptose-1-phosphate adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-beta-D-heptose-1-phosphate + ATP = ADP-D-glycero-D-manno-heptose." [MetaCyc:RXN0-4342]
subset: gosubset_prok
synonym: "D-beta-D-heptose 1-phosphate adenylyltransferase activity" EXACT []
synonym: "heptose 1-phosphate adenyltransferase activity" EXACT []
xref: IMG:02786
xref: MetaCyc:RXN0-4342
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0033787
name: cyanocobalamin reductase (cyanide-eliminating) activity
namespace: molecular_function
def: "Catalysis of the reaction: cob(I)alamin + hydrogen cyanide + NADP(+) = cyanocob(III)alamin + H(+) + NADPH." [EC:1.16.1.6, RHEA:16116]
synonym: "cob(I)alamin, cyanide:NADP+ oxidoreductase activity" EXACT [EC:1.16.1.6]
synonym: "cyanocobalamin reductase (NADPH, cyanide-eliminating) activity" EXACT [EC:1.16.1.6]
synonym: "cyanocobalamin reductase (NADPH; CN-eliminating) activity" EXACT [EC:1.16.1.6]
synonym: "cyanocobalamin reductase activity" EXACT [EC:1.16.1.6]
synonym: "NADPH2:cyanocob(III)alamin oxidoreductase (cyanide-eliminating) activity" EXACT [EC:1.16.1.6]
synonym: "NADPH:cyanocob(III)alamin oxidoreductase (cyanide-eliminating) activity" EXACT [EC:1.16.1.6]
xref: EC:1.16.1.6
xref: KEGG:R02999
xref: MetaCyc:1.6.99.12-RXN
xref: RHEA:16116
is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor

[Term]
id: GO:0033788
name: leucoanthocyanidin reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2R,3S)-catechin + NADP+ + H2O = 2,3-trans-3,4-cis-leucocyanidin + NADPH + H+." [EC:1.17.1.3]
synonym: "(2R,3S)-catechin:NADP+ 4-oxidoreductase activity" EXACT [EC:1.17.1.3]
synonym: "leucocyanidin reductase activity" EXACT [EC:1.17.1.3]
xref: EC:1.17.1.3
xref: MetaCyc:RXN-1484
xref: RHEA:10619
is_a: GO:0016726 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor

[Term]
id: GO:0033789
name: phenylacetyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 1,4-benzoquinone + H(2)O + phenylacetyl-CoA = 2 hydroquinone + phenylglyoxylyl-CoA." [EC:1.17.5.1, RHEA:15708]
synonym: "phenylacetyl-CoA:acceptor oxidoreductase activity" EXACT [EC:1.17.5.1]
synonym: "phenylacetyl-CoA:quinone oxidoreductase activity" EXACT [EC:1.17.5.1]
xref: EC:1.17.5.1
xref: KEGG:R07222
xref: MetaCyc:1.17.5.1-RXN
xref: RHEA:15708
is_a: GO:0033695 ! oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor

[Term]
id: GO:0033790
name: hydroxymethylfurfural reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-hydroxymethylfurfural + NAD(P)H + H+ = 2,5-bis-hydroxymethylfuran + NAD(P)+." [GOC:jp, GOC:mah, PMID:15338422, PMID:16652391]
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033791
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O + acceptor = (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + reduced acceptor." [EC:1.17.99.3]
synonym: "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA:acceptor 24-oxidoreductase (24R-hydroxylating) activity" EXACT [EC:1.17.99.3]
synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate 24-hydroxylase activity" EXACT [EC:1.17.99.3]
synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA oxidase activity" EXACT [EC:1.17.99.3]
synonym: "THC-CoA oxidase activity" EXACT [EC:1.17.99.3]
synonym: "THCA-CoA oxidase activity" EXACT [EC:1.17.99.3]
synonym: "trihydroxycoprostanoyl-CoA oxidase activity" EXACT [EC:1.17.99.3]
xref: EC:1.17.99.3
xref: MetaCyc:1.17.99.3-RXN
xref: RHEA:15736
is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups

[Term]
id: GO:0033792
name: bile-acid 7alpha-dehydroxylase activity
namespace: molecular_function
def: "Catalysis of the reactions: deoxycholate + FAD + H2O = cholate + FADH2, and lithocholate + FAD + H2O = chenodeoxycholate + FADH2." [EC:1.17.99.5]
synonym: "7alpha-dehydroxylase activity" EXACT [EC:1.17.99.5]
synonym: "bile acid 7-dehydroxylase activity" EXACT [EC:1.17.99.5]
synonym: "cholate 7alpha-dehydroxylase activity" EXACT [EC:1.17.99.5]
synonym: "deoxycholate:FAD oxidoreductase (7alpha-dehydroxylating) activity" EXACT [EC:1.17.99.5]
synonym: "deoxycholate:NAD+ oxidoreductase activity" EXACT [EC:1.17.99.5]
xref: EC:1.17.99.5
xref: MetaCyc:RXN-8658
xref: MetaCyc:RXN-8659
is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups

[Term]
id: GO:0033793
name: aureusidin synthase activity
namespace: molecular_function
def: "Catalysis of the reactions: 2',4,4',6'-tetrahydroxychalcone + O2 = aureusidin + H2O, and 2',3,4,4',6'-pentahydroxychalcone + 1/2 O2 = aureusidin + H2O." [EC:1.21.3.6]
synonym: "2',4,4',6'-tetrahydroxychalcone:oxygen oxidoreductase activity" EXACT [EC:1.21.3.6]
xref: EC:1.21.3.6
is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor

[Term]
id: GO:0033794
name: sarcosine reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl phosphate + methylamine + thioredoxin disulfide = N-methylglycine + phosphate + thioredoxin." [EC:1.21.4.3]
synonym: "acetyl-phosphate methylamine:thioredoxin disulfide oxidoreductase (N-methylglycine-forming) activity" EXACT [EC:1.21.4.3]
xref: EC:1.21.4.3
xref: RHEA:12828
is_a: GO:0050485 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor

[Term]
id: GO:0033795
name: betaine reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl phosphate + trimethylamine + thioredoxin disulfide = N,N,N-trimethylglycine + phosphate + thioredoxin." [EC:1.21.4.4]
synonym: "acetyl-phosphate trimethylamine:thioredoxin disulfide oxidoreductase (N,N,N-trimethylglycine-forming) activity" EXACT [EC:1.21.4.4]
xref: EC:1.21.4.4
xref: RHEA:11851
is_a: GO:0050485 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor

[Term]
id: GO:0033796
name: sulfur reductase activity
namespace: molecular_function
def: "Catalysis of the reduction of elemental sulfur or polysulfide to hydrogen sulfide." [EC:1.97.1.3]
synonym: "(donor):sulfur oxidoreductase activity" EXACT [EC:1.97.1.3]
synonym: "sulphur reductase activity" EXACT []
xref: EC:1.97.1.3
xref: MetaCyc:1.97.1.3-RXN
xref: MetaCyc:RXN-8269
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0033797
name: selenate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 e(-) + 2 H(+) + selenate = H(2)O + selenite." [EC:1.97.1.9, RHEA:14031]
synonym: "selenite:reduced acceptor oxidoreductase activity" EXACT [EC:1.97.1.9]
xref: EC:1.97.1.9
xref: KEGG:R07229
xref: MetaCyc:RXN0-2101
xref: RHEA:14031
xref: UM-BBD_reactionID:r0828
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0033798
name: thyroxine 5-deiodinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,3',5'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2." [EC:1.97.1.11]
synonym: "acceptor:3,3',5'-triiodo-L-thyronine oxidoreductase (iodinating) activity" EXACT [EC:1.97.1.11]
synonym: "diiodothyronine 5'-deiodinase activity" BROAD [EC:1.97.1.11]
synonym: "inner ring-deiodinating pathway" EXACT [PMID:20403357]
synonym: "iodothyronine 5-deiodinase activity" EXACT [EC:1.97.1.11]
synonym: "iodothyronine inner ring monodeiodinase activity" EXACT [EC:1.97.1.11]
synonym: "type III iodothyronine deiodinase activity" NARROW [EC:1.97.1.11]
xref: EC:1.97.1.11
xref: MetaCyc:1.97.1.11-RXN
xref: RHEA:18900
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0033799
name: myricetin 3'-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + myricetin = S-adenosyl-L-homocysteine + laricitrin." [MetaCyc:RXN-8451]
comment: Note that this term represents one of two reactions that are grouped together in EC 2.1.1.149.
synonym: "CrCOMT2" RELATED [EC:2.1.1.149]
synonym: "flavonoid 3',5'-O-dimethyltransferase activity" RELATED [EC:2.1.1.149]
synonym: "S-adenosyl-L-methionine:myricetin O-methyltransferase activity" RELATED [EC:2.1.1.149]
xref: EC:2.1.1.149
xref: KEGG:R06815
xref: MetaCyc:RXN-8451
xref: RHEA:24283
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0033800
name: isoflavone 7-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + a 7-hydroxyisoflavone = S-adenosyl-L-homocysteine + a 7-methoxyisoflavone." [EC:2.1.1.150]
synonym: "S-adenosyl-L-methionine:hydroxyisoflavone 7-O-methyltransferase activity" EXACT [EC:2.1.1.150]
xref: EC:2.1.1.150
xref: MetaCyc:RXN-6241
xref: RHEA:17936
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0033801
name: vitexin 2''-O-rhamnoside 7-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + vitexin 2''-O-beta-L-rhamnoside = S-adenosyl-L-homocysteine + 7-O-methylvitexin 2''-O-beta-L-rhamnoside." [EC:2.1.1.153]
synonym: "S-adenosyl-L-methionine:vitexin-2''-O-beta-L-rhamnoside 7-O-methyltransferase activity" EXACT [EC:2.1.1.153]
xref: EC:2.1.1.153
xref: MetaCyc:RXN-4981
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0033802
name: isoliquiritigenin 2'-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + isoliquiritigenin = 2'-O-methylisoliquiritigenin + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.154, RHEA:21611]
synonym: "chalcone OMT" RELATED [EC:2.1.1.154]
synonym: "CHMT" RELATED [EC:2.1.1.154]
synonym: "S-adenosyl-L-methionine:isoliquiritigenin 2'-O-methyltransferase activity" EXACT [EC:2.1.1.154]
xref: EC:2.1.1.154
xref: KEGG:R07242
xref: MetaCyc:RXN-3501
xref: RHEA:21611
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0033803
name: kaempferol 4'-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + kaempferol = S-adenosyl-L-homocysteine + H(+) + kaempferide." [EC:2.1.1.155, RHEA:15108]
synonym: "F 4'-OMT" RELATED [EC:2.1.1.155]
synonym: "S-adenosyl-L-methionine:flavonoid 4'-O-methyltransferase activity" EXACT [EC:2.1.1.155]
synonym: "S-adenosyl-L-methionine:kaempferol 4'-O-methyltransferase activity" EXACT [EC:2.1.1.155]
xref: EC:2.1.1.155
xref: KEGG:R06807
xref: MetaCyc:2.1.1.155-RXN
xref: RHEA:15108
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0033804
name: obsolete glycine/sarcosine N-methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reactions: S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine, and S-adenosyl-L-methionine + sarcosine = S-adenosyl-L-homocysteine + N,N-dimethylglycine." [EC:2.1.1.156]
comment: This term was made obsolete because it represents two reactions, and should be two separate terms.
synonym: "ApGSMT" RELATED [EC:2.1.1.156]
synonym: "glycine sarcosine N-methyltransferase activity" EXACT [EC:2.1.1.156]
synonym: "glycine-sarcosine methyltransferase activity" EXACT [EC:2.1.1.156]
synonym: "glycine/sarcosine N-methyltransferase activity" EXACT []
synonym: "GMT" RELATED [EC:2.1.1.156]
synonym: "GSMT" RELATED [EC:2.1.1.156]
synonym: "S-adenosyl-L-methionine:sarcosine N-methyltransferase activity" EXACT [EC:2.1.1.156]
is_obsolete: true
consider: GO:0017174
consider: GO:0052730

[Term]
id: GO:0033805
name: obsolete sarcosine/dimethylglycine N-methyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reactions: S-adenosyl-L-methionine + sarcosine = S-adenosyl-L-homocysteine + N,N-dimethylglycine, and S-adenosyl-L-methionine + N,N-dimethylglycine = S-adenosyl-L-homocysteine + betaine." [EC:2.1.1.157]
comment: This term was made obsolete because it represents two reactions, and should be two separate terms.
synonym: "ApDMT" RELATED [EC:2.1.1.157]
synonym: "S-adenosyl-L-methionine:N,N-dimethylglycine N-methyltransferase activity" NARROW [EC:2.1.1.157]
synonym: "sarcosine dimethylglycine methyltransferase activity" NARROW [EC:2.1.1.157]
synonym: "sarcosine dimethylglycine N-methyltransferase activity" NARROW [EC:2.1.1.157]
synonym: "sarcosine/dimethylglycine N-methyltransferase activity" EXACT []
synonym: "SDMT" RELATED [EC:2.1.1.157]
is_obsolete: true
consider: GO:0052729
consider: GO:0052730

[Term]
id: GO:0033806
name: fluorothreonine transaldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-threonine + fluoroacetaldehyde = acetaldehyde + 4-fluoro-L-threonine." [EC:2.2.1.8]
synonym: "fluoroacetaldehyde:L-threonine aldehydetransferase activity" EXACT [EC:2.2.1.8]
xref: EC:2.2.1.8
xref: RHEA:11751
is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups

[Term]
id: GO:0033807
name: icosanoyl-CoA synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: stearoyl-CoA + malonyl-CoA + 2 NAD(P)H + 2 H+ = icosanoyl-CoA + CO2 + 2 NAD(P)+." [EC:2.3.1.119]
synonym: "acyl-CoA elongase activity" EXACT [EC:2.3.1.119]
synonym: "C18-CoA elongase activity" EXACT [EC:2.3.1.119]
synonym: "stearoyl-CoA elongase activity" EXACT [EC:2.3.1.119]
synonym: "stearoyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing) activity" EXACT [EC:2.3.1.119]
xref: EC:2.3.1.119
xref: MetaCyc:ICOSANOYL-COA-SYNTHASE-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0033808
name: 6'-deoxychalcone synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA + NADPH + H+ = 4 CoA + isoliquiritigenin + 3 CO2 + NADP+ + H2O." [EC:2.3.1.170]
synonym: "malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing, reducing) activity" EXACT [EC:2.3.1.170]
xref: EC:2.3.1.170
xref: MetaCyc:RXN-3142
xref: RHEA:10587
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0033809
name: anthocyanin 6''-O-malonyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: malonyl-CoA + an anthocyanidin 3-O-beta-D-glucoside = CoA + an anthocyanidin 3-O-(6-O-malonyl-beta-D-glucoside)." [EC:2.3.1.171]
synonym: "3MaT" RELATED [EC:2.3.1.171]
synonym: "Dv3MaT" RELATED [EC:2.3.1.171]
synonym: "malonyl-CoA:anthocyanidin-3-O-beta-D-glucoside 6''-O-malonyltransferase activity" EXACT [EC:2.3.1.171]
synonym: "malonyl-coenzymeA:anthocyanidin-3-O-beta-D-glucoside 6''-O-malonyltransferase activity" EXACT [EC:2.3.1.171]
xref: EC:2.3.1.171
xref: MetaCyc:2.3.1.171-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0033810
name: anthocyanin 5-O-glucoside 6'''-O-malonyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: malonyl-CoA + pelargonidin 3-O-(6-caffeoyl-beta-D-glucoside) 5-O-beta-D-glucoside = CoA + 4'''-demalonylsalvianin." [EC:2.3.1.172]
synonym: "malonyl-CoA:pelargonidin-3-O-(6-caffeoyl-beta-D-glucoside)-5-O-beta-D-glucoside 6'''-O-malonyltransferase activity" EXACT [EC:2.3.1.172]
synonym: "Ss5MaT1" RELATED [EC:2.3.1.172]
xref: EC:2.3.1.172
xref: MetaCyc:2.3.1.172-RXN
xref: RHEA:21991
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0033811
name: flavonol-3-O-triglucoside O-coumaroyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-coumaroyl-CoA + a flavonol 3-O-[beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] = CoA + a flavonol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside]." [EC:2.3.1.173]
synonym: "4-coumaroyl-CoA:flavonol-3-O-[beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] 6'''-O-4-coumaroyltransferase activity" EXACT [EC:2.3.1.173]
xref: EC:2.3.1.173
xref: MetaCyc:2.3.1.173-RXN
xref: RHEA:22163
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0033812
name: 3-oxoadipyl-CoA thiolase activity
namespace: molecular_function
def: "Catalysis of the reaction: succinyl-CoA + acetyl-CoA = CoA + 3-oxoadipyl-CoA." [EC:2.3.1.174]
synonym: "succinyl-CoA:acetyl-CoA C-succinyltransferase activity" EXACT [EC:2.3.1.174]
xref: EC:2.3.1.174
xref: MetaCyc:RXN-3641
xref: RHEA:19484
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0033813
name: deacetylcephalosporin-C acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + deacetylcephalosporin C = cephalosporin C + CoA." [EC:2.3.1.175, RHEA:23863]
synonym: "acetyl coenzyme A:DAC acetyltransferase activity" EXACT [EC:2.3.1.175]
synonym: "acetyl-CoA:DAC acetyltransferase activity" EXACT [EC:2.3.1.175]
synonym: "acetyl-CoA:DAC O-acetyltransferase activity" EXACT [EC:2.3.1.175]
synonym: "acetyl-CoA:deacetylcephalosporin-C acetyltransferase activity" EXACT [EC:2.3.1.175]
synonym: "acetyl-CoA:deacetylcephalosporin-C O-acetyltransferase activity" EXACT [EC:2.3.1.175]
synonym: "cefG" RELATED [EC:2.3.1.175]
synonym: "CPC acetylhydrolase activity" EXACT [EC:2.3.1.175]
synonym: "DAC acetyltransferase activity" EXACT [EC:2.3.1.175]
synonym: "DAC-AT" RELATED [EC:2.3.1.175]
synonym: "deacetylcephalosporin C acetyltransferase activity" EXACT [EC:2.3.1.175]
xref: EC:2.3.1.175
xref: KEGG:R03064
xref: MetaCyc:2.3.1.175-RXN
xref: RHEA:23863
is_a: GO:0016408 ! C-acyltransferase activity

[Term]
id: GO:0033814
name: propanoyl-CoA C-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA + propanoyl-CoA = CoA + 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA." [EC:2.3.1.176]
synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA:propanoyl-CoA C-acyltransferase activity" EXACT [EC:2.3.1.176]
synonym: "peroxisomal thiolase 2 activity" NARROW [EC:2.3.1.176]
synonym: "PTE-2" RELATED [EC:2.3.1.176]
synonym: "SCP-X" RELATED [EC:2.3.1.176]
synonym: "SCPchi" RELATED [EC:2.3.1.176]
synonym: "sterol carrier protein-chi" RELATED [EC:2.3.1.176]
synonym: "sterol carrier protein-X" RELATED [EC:2.3.1.176]
xref: EC:2.3.1.176
xref: MetaCyc:2.3.1.176-RXN
xref: RHEA:16868
is_a: GO:0016408 ! C-acyltransferase activity

[Term]
id: GO:0033815
name: biphenyl synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3 malonyl-CoA + benzoyl-CoA = 4 CoA + 3,5-dihydroxybiphenyl + 4 CO2." [EC:2.3.1.177]
synonym: "BIS" RELATED [EC:2.3.1.177]
synonym: "malonyl-CoA:benzoyl-CoA malonyltransferase activity" EXACT [EC:2.3.1.177]
xref: EC:2.3.1.177
xref: MetaCyc:2.3.1.177-RXN
xref: RHEA:22295
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0033816
name: diaminobutyrate acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-2,4-diaminobutyrate + acetyl-CoA = N(4)-acetyl-L-2,4-diaminobutyrate + CoA + H(+)." [EC:2.3.1.178, RHEA:16904]
synonym: "2,4-diaminobutanoate acetyltransferase activity" EXACT [EC:2.3.1.178]
synonym: "acetyl-CoA:L-2,4-diaminobutanoate 4-N-acetyltransferase activity" EXACT [EC:2.3.1.178]
synonym: "acetyl-CoA:L-2,4-diaminobutanoate N4-acetyltransferase activity" EXACT [EC:2.3.1.178]
synonym: "DAB acetyltransferase activity" EXACT [EC:2.3.1.178]
synonym: "DABA acetyltransferase activity" EXACT [EC:2.3.1.178]
synonym: "DABAcT" RELATED [EC:2.3.1.178]
synonym: "diaminobutyric acid acetyltransferase activity" EXACT [EC:2.3.1.178]
synonym: "EctA" RELATED [EC:2.3.1.178]
synonym: "L-2,4-diaminobutanoate acetyltransferase activity" EXACT [EC:2.3.1.178]
synonym: "L-2,4-diaminobutyrate acetyltransferase activity" EXACT [EC:2.3.1.178]
xref: EC:2.3.1.178
xref: KEGG:R06978
xref: MetaCyc:R102-RXN
xref: RHEA:16904
is_a: GO:0016407 ! acetyltransferase activity

[Term]
id: GO:0033817
name: beta-ketoacyl-acyl-carrier-protein synthase II activity
namespace: molecular_function
def: "Catalysis of the reaction: (Z)-hexadec-11-enoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = (Z)-3-oxooctadec-13-enoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]." [EC:2.3.1.179]
synonym: "(Z)-hexadec-11-enoyl-acyl-carrier-protein:malonyl-acyl-carrier-protein C-acyltransferase (decarboxylating) activity" EXACT [EC:2.3.1.179]
synonym: "3-oxoacyl-acyl carrier protein synthase I activity" EXACT [EC:2.3.1.179]
synonym: "beta-ketoacyl-ACP synthase II activity" EXACT [EC:2.3.1.179]
synonym: "FabF" RELATED [EC:2.3.1.179]
synonym: "KAS II" RELATED [EC:2.3.1.179]
synonym: "KASII" RELATED [EC:2.3.1.179]
xref: EC:2.3.1.179
xref: MetaCyc:2.3.1.179-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0033818
name: beta-ketoacyl-acyl-carrier-protein synthase III activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + malonyl-[acyl-carrier protein] = acetoacyl-[acyl-carrier protein] + CoA + CO2." [EC:2.3.1.180]
synonym: "3-ketoacyl-acyl carrier protein synthase III activity" EXACT [EC:2.3.1.180]
synonym: "3-oxoacyl:ACP synthase III activity" EXACT [EC:2.3.1.180]
synonym: "acetyl-CoA:malonyl-acyl-carrier-protein C-acyltransferase activity" EXACT [EC:2.3.1.180]
synonym: "beta-ketoacyl (acyl carrier protein) synthase III activity" EXACT [EC:2.3.1.180]
synonym: "beta-ketoacyl-ACP synthase III activity" EXACT [EC:2.3.1.180]
synonym: "beta-ketoacyl-acyl carrier protein synthase III activity" EXACT [EC:2.3.1.180]
synonym: "FabH" RELATED [EC:2.3.1.180]
synonym: "KAS III" RELATED [EC:2.3.1.180]
synonym: "KASIII" RELATED [EC:2.3.1.180]
xref: EC:2.3.1.180
xref: MetaCyc:2.3.1.180-RXN
xref: RHEA:12083
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0033819
name: lipoyl(octanoyl) transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: octanoyl-[acyl-carrier protein] + protein = protein N6-(octanoyl)lysine + acyl-carrier protein." [EC:2.3.1.181]
synonym: "LipB" RELATED [EC:2.3.1.181]
synonym: "lipoate/octanoate transferase activity" EXACT [EC:2.3.1.181]
synonym: "lipoyl (octanoyl)-acyl carrier protein:protein transferase activity" EXACT [EC:2.3.1.181]
synonym: "lipoyl (octanoyl)-acyl-carrier-protein-protein N-lipoyltransferase activity" EXACT [EC:2.3.1.181]
synonym: "octanoyl-acyl carrier protein-protein N-octanoyltransferase activity" EXACT [EC:2.3.1.181]
synonym: "octanoyl-acyl-carrier-protein-protein N-octanoyltransferase activity" EXACT [EC:2.3.1.181]
synonym: "octanoyl-acyl-carrier-protein:protein N-octanoyltransferase activity" EXACT [EC:2.3.1.181]
xref: EC:2.3.1.181
xref: MetaCyc:RXN0-947
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0033820
name: DNA alpha-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an alpha-D-glucosyl residue from UDP-glucose to a hydroxymethylcytosine residue in DNA." [EC:2.4.1.26]
synonym: "T2-HMC-alpha-glucosyl transferase activity" EXACT [EC:2.4.1.26]
synonym: "T4-HMC-alpha-glucosyl transferase activity" EXACT [EC:2.4.1.26]
synonym: "T6-HMC-alpha-glucosyl transferase activity" EXACT [EC:2.4.1.26]
synonym: "UDP-glucose:DNA alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.26]
synonym: "UDPglucose-DNA alpha-glucosyltransferase activity" EXACT [EC:2.4.1.26]
synonym: "uridine diphosphoglucose-deoxyribonucleate alpha-glucosyltransferase activity" EXACT [EC:2.4.1.26]
xref: EC:2.4.1.26
xref: MetaCyc:2.4.1.26-RXN
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0033821
name: DNA beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a beta-D-glucosyl residue from UDP-glucose to a hydroxymethylcytosine residue in DNA." [EC:2.4.1.27]
synonym: "T4 phage beta-glucosyltransferase activity" EXACT [EC:2.4.1.27]
synonym: "T4-beta-glucosyl transferase activity" EXACT [EC:2.4.1.27]
synonym: "T4-HMC-beta-glucosyl transferase activity" EXACT [EC:2.4.1.27]
synonym: "UDP glucose-DNA beta-glucosyltransferase activity" EXACT [EC:2.4.1.27]
synonym: "UDP-glucose:DNA beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.27]
synonym: "UDPglucose:DNA beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.27]
synonym: "uridine diphosphoglucose-deoxyribonucleate beta-glucosyltransferase activity" EXACT [EC:2.4.1.27]
xref: EC:2.4.1.27
xref: MetaCyc:2.4.1.27-RXN
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0033822
name: glucosyl-DNA beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a beta-D-glucosyl residue from UDP-glucose to a glucosylhydroxymethylcytosine residue in DNA." [EC:2.4.1.28]
synonym: "T6-beta-glucosyl transferase activity" EXACT [EC:2.4.1.28]
synonym: "T6-glucosyl-HMC-beta-glucosyl transferase activity" EXACT [EC:2.4.1.28]
synonym: "UDP-glucose:D-glucosyl-DNA beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.28]
synonym: "UDPglucose:D-glucosyl-DNA beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.28]
synonym: "uridine diphosphoglucose-glucosyldeoxyribonucleate beta-glucosyltransferase activity" EXACT [EC:2.4.1.28]
xref: EC:2.4.1.28
xref: MetaCyc:2.4.1.28-RXN
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0033823
name: procollagen glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen = UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen." [EC:2.4.1.66]
synonym: "collagen glucosyltransferase activity" EXACT [EC:2.4.1.66]
synonym: "collagen hydroxylysyl glucosyltransferase activity" EXACT [EC:2.4.1.66]
synonym: "galactosylhydroxylysine glucosyltransferase activity" EXACT [EC:2.4.1.66]
synonym: "galactosylhydroxylysine-glucosyltransferase activity" EXACT [EC:2.4.1.66]
synonym: "galactosylhydroxylysyl glucosyltransferase activity" EXACT [EC:2.4.1.66]
synonym: "UDP-glucose-collagenglucosyltransferase activity" EXACT [EC:2.4.1.66]
synonym: "UDP-glucose:5-(D-galactosyloxy)-L-lysine-procollagen D-glucosyltransferase activity" EXACT [EC:2.4.1.66]
synonym: "UDPglucose:5-(D-galactosyloxy)-L-lysine-procollagen D-glucosyltransferase activity" EXACT [EC:2.4.1.66]
synonym: "uridine diphosphoglucose-collagen glucosyltransferase activity" EXACT [EC:2.4.1.66]
xref: EC:2.4.1.66
xref: MetaCyc:PROCOLLAGEN-GLUCOSYLTRANSFERASE-RXN
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0033824
name: alternansucrase activity
namespace: molecular_function
def: "Catalysis of the transfer of an alpha-D-glucosyl residue from sucrose to alternately the 6-position and the 3-position of the non-reducing terminal residue of an alpha-D-glucan, thus producing a glucan having alternating alpha-1,6- and alpha-1,3-linkages." [EC:2.4.1.140]
synonym: "sucrose-1,6(3)-alpha-glucan 6(3)-alpha-glucosyltransferase activity" EXACT [EC:2.4.1.140]
synonym: "sucrose:1,6(1,3)-alpha-D-glucan 6(3)-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.140]
synonym: "sucrose:1,6-, 1,3-alpha-D-glucan 3-alpha- and 6-alpha-D-glucosyltransferase activity" BROAD [EC:2.4.1.140]
xref: EC:2.4.1.140
xref: MetaCyc:2.4.1.140-RXN
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0033825
name: oligosaccharide 4-alpha-D-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of the non-reducing terminal alpha-D-glucose residue from a 1,4-alpha-D-glucan to the 4-position of an alpha-D-glucan, thus bringing about the hydrolysis of oligosaccharides." [EC:2.4.1.161]
synonym: "1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.161]
synonym: "1,4-alpha-glucan:1,4-alpha-glucan 4-alpha-glucosyltransferase activity" EXACT [EC:2.4.1.161]
synonym: "amylase III activity" EXACT [EC:2.4.1.161]
xref: EC:2.4.1.161
xref: MetaCyc:2.4.1.161-RXN
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0033826
name: xyloglucan 4-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a beta-D-glucosyl residue from UDP-glucose on to a glucose residue in xyloglucan, forming a beta-1,4-D-glucosyl-D-glucose linkage." [EC:2.4.1.168]
synonym: "UDP-glucose:xyloglucan 1,4-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.168]
synonym: "UDPglucose:xyloglucan 1,4-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.168]
synonym: "uridine diphosphoglucose-xyloglucan 4beta-glucosyltransferase activity" EXACT [EC:2.4.1.168]
synonym: "xyloglucan 4beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.168]
synonym: "xyloglucan glucosyltransferase activity" EXACT [EC:2.4.1.168]
xref: EC:2.4.1.168
xref: MetaCyc:2.4.1.168-RXN
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0033827
name: high-mannose-oligosaccharide beta-1,4-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an N-acetyl-D-glucosamine residue from UDP-N-acetyl-D-glucosamine to the 4-position of a mannose linked alpha-1,6 to the core mannose of high-mannose oligosaccharides produced by Dictyostelium discoideum." [EC:2.4.1.197]
synonym: "acetylglucosamine-oligosaccharide acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.197]
synonym: "UDP-GlcNAc:oligosaccharide beta-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.197]
synonym: "UDP-N-acetyl-D-glucosamine:high-mannose-oligosaccharide beta-1,4-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.197]
synonym: "uridine diphosphoacetylglucosamine-oligosaccharide acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.197]
xref: EC:2.4.1.197
xref: MetaCyc:2.4.1.197-RXN
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0033828
name: glucosylglycerol-phosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: sn-glycerol 3-phosphate + ADP-glucose = 2-O-(beta-D-glucosyl)-sn-glycerol 3-phosphate + ADP + H(+)." [EC:2.4.1.213, RHEA:12884]
synonym: "ADP-glucose:sn-glycerol-3-phosphate 2-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.213]
synonym: "ADPglucose:sn-glycerol-3-phosphate 2-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.213]
synonym: "GG-phosphate synthase activity" EXACT [EC:2.4.1.213]
synonym: "GGPS" RELATED [EC:2.4.1.213]
synonym: "glucosyl-glycerol-phosphate synthase activity" EXACT [EC:2.4.1.213]
xref: EC:2.4.1.213
xref: KEGG:R05328
xref: MetaCyc:2.4.1.213-RXN
xref: RHEA:12884
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0033829
name: O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor." [EC:2.4.1.222]
synonym: "O-fucosylpeptide beta-1,3-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.222]
synonym: "UDP-D-GlcNAc:O-L-fucosylpeptide 3-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.222]
xref: EC:2.4.1.222
xref: MetaCyc:2.4.1.222-RXN
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0033830
name: Skp1-protein-hydroxyproline N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetylglucosamine + Skp1-protein-hydroxyproline = UDP + Skp1-protein-O-(N-acetyl-D-glucosaminyl)hydroxyproline." [EC:2.4.1.229]
synonym: "Skp1-HyPro GlcNAc-transferase activity" EXACT [EC:2.4.1.229]
synonym: "UDP-GlcNAc:hydroxyproline polypeptide GlcNAc-transferase activity" EXACT [EC:2.4.1.229]
synonym: "UDP-GlcNAc:Skp1-hydroxyproline GlcNAc-transferase activity" EXACT [EC:2.4.1.229]
synonym: "UDP-N-acetyl-D-glucosamine:Skp1-protein-hydroxyproline N-acetyl-D-glucosaminyl-transferase activity" EXACT [EC:2.4.1.229]
synonym: "UDP-N-acetylglucosamine (GlcNAc):hydroxyproline polypeptide GlcNAc-transferase activity" EXACT [EC:2.4.1.229]
xref: EC:2.4.1.229
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0033831
name: kojibiose phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: kojibiose + phosphate = beta-D-glucose 1-phosphate + D-glucose." [EC:2.4.1.230, RHEA:11179]
synonym: "2-alpha-D-glucosyl-D-glucose:phosphate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.230]
xref: EC:2.4.1.230
xref: KEGG:R07264
xref: MetaCyc:2.4.1.230-RXN
xref: RHEA:11179
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0033832
name: alpha,alpha-trehalose phosphorylase (configuration-retaining) activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha,alpha-trehalose + phosphate = alpha-D-glucose + alpha-D-glucose 1-phosphate." [EC:2.4.1.231]
synonym: "alpha,alpha-trehalose:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.231]
synonym: "trehalose phosphorylase activity" BROAD [EC:2.4.1.231]
xref: MetaCyc:RXN-4441
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0033833
name: hydroxymethylfurfural reductase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-hydroxymethylfurfural + NADH + H+ = 2,5-bis-hydroxymethylfuran + NAD+." [GOC:jp, GOC:mah, PMID:15338422, PMID:16652391]
xref: MetaCyc:RXN-10738
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033834
name: kaempferol 3-O-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-galactose + kaempferol = UDP + kaempferol 3-O-beta-D-galactoside." [EC:2.4.1.234]
synonym: "F3GalTase activity" EXACT [EC:2.4.1.234]
synonym: "UDP-galactose:kaempferol 3-O-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.234]
xref: EC:2.4.1.234
xref: MetaCyc:2.4.1.234-RXN
is_a: GO:0008378 ! galactosyltransferase activity

[Term]
id: GO:0033835
name: flavanone 7-O-glucoside 2''-O-beta-L-rhamnosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-L-rhamnose + a flavanone 7-O-glucoside = UDP + a flavanone 7-O-[beta-L-rhamnosyl-(1->2)-beta-D-glucoside]." [EC:2.4.1.236]
synonym: "1->2 UDP-rhamnosyltransferase activity" EXACT [EC:2.4.1.236]
synonym: "UDP-L-rhamnose:flavanone-7-O-glucoside 2''-O-beta-L-rhamnosyltransferase activity" EXACT [EC:2.4.1.236]
synonym: "UDP-rhamnose:flavanone-7-O-glucoside-2''-O-rhamnosyltransferase activity" EXACT [EC:2.4.1.236]
xref: EC:2.4.1.236
xref: MetaCyc:RXN-5001
xref: MetaCyc:RXN-5002
xref: MetaCyc:RXN-5004
xref: MetaCyc:RXN-7759
xref: MetaCyc:RXN-9699
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0033836
name: flavonol 7-O-beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + a flavonol = UDP + a flavonol 7-O-beta-D-glucoside." [EC:2.4.1.237]
synonym: "UDP-glucose:flavonol 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.237]
synonym: "UDP-glucose:flavonol 7-O-glucosyltransferase activity" EXACT [EC:2.4.1.237]
xref: EC:2.4.1.237
xref: MetaCyc:2.4.1.237-RXN
xref: RHEA:23167
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0033837
name: anthocyanin 3'-O-beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + an anthocyanin = UDP + an anthocyanin 3'-O-beta-D-glucoside." [EC:2.4.1.238]
synonym: "3'GT" RELATED [EC:2.4.1.238]
synonym: "UDP-glucose:anthocyanin 3'-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.238]
synonym: "UDP-glucose:anthocyanin 3'-O-glucosyltransferase activity" EXACT [EC:2.4.1.238]
xref: EC:2.4.1.238
xref: MetaCyc:2.4.1.238-RXN
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0033838
name: flavonol-3-O-glucoside glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + a flavonol 3-O-beta-D-glucoside = UDP + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside." [EC:2.4.1.239]
synonym: "UDP-glucose:flavonol-3-O-glucoside 2''-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.239]
xref: EC:2.4.1.239
xref: MetaCyc:2.4.1.239-RXN
xref: RHEA:18896
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0033839
name: flavonol-3-O-glycoside glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside = UDP + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside." [EC:2.4.1.240]
synonym: "UDP-glucose:flavonol-3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside 2'''-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.240]
xref: EC:2.4.1.240
xref: MetaCyc:2.4.1.240-RXN
xref: RHEA:23547
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0033840
name: NDP-glucose-starch glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: NDP-glucose + (1,4-alpha-D-glucosyl)n = NDP + (1,4-alpha-D-glucosyl)n+1." [EC:2.4.1.242]
synonym: "GBSS" RELATED [EC:2.4.1.242]
synonym: "GBSSI" RELATED [EC:2.4.1.242]
synonym: "GBSSII" RELATED [EC:2.4.1.242]
synonym: "granule-bound starch synthase activity" EXACT [EC:2.4.1.242]
synonym: "granule-bound starch synthase I activity" EXACT [EC:2.4.1.242]
synonym: "granule-bound starch synthase II activity" EXACT [EC:2.4.1.242]
synonym: "NDP-glucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.242]
synonym: "NDPglucose-starch glucosyltransferase activity" EXACT [EC:2.4.1.242]
synonym: "starch granule-bound nucleoside diphosphate glucose-starch glucosyltransferase activity" EXACT [EC:2.4.1.242]
synonym: "starch synthase II activity" EXACT [EC:2.4.1.242]
synonym: "waxy protein" RELATED [EC:2.4.1.242]
xref: EC:2.4.1.242
xref: MetaCyc:2.4.1.242-RXN
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0033841
name: 6G-fructosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: [1-beta-D-fructofuranosyl-(2->1)-]m+1 alpha-D-glucopyranoside + [1-beta-D-fructofuranosyl-(2->1)-]n+1 alpha-D-glucopyranoside = [1-beta-D-fructofuranosyl-(2->1)-]m alpha-D-glucopyranoside + [1-beta-D-fructofuranosyl-(2->1)-]n+1 beta-D-fructofuranosyl-(2->6)-alpha-D-glucopyranoside (m > 0; n >= 0)." [EC:2.4.1.243]
synonym: "1F-oligo[beta-D-fructofuranosyl-(2->1)-]sucrose 6G-beta-D-fructotransferase activity" EXACT [EC:2.4.1.243]
synonym: "6G-FFT" RELATED [EC:2.4.1.243]
synonym: "6G-fructotransferase activity" EXACT [EC:2.4.1.243]
synonym: "6G-FT" RELATED [EC:2.4.1.243]
synonym: "fructan:fructan 6G-fructosyltransferase activity" EXACT [EC:2.4.1.243]
xref: EC:2.4.1.243
xref: MetaCyc:2.4.1.243-RXN
is_a: GO:0050738 ! fructosyltransferase activity

[Term]
id: GO:0033842
name: N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + N-acetyl-beta-D-glucosaminyl group = UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group." [EC:2.4.1.244]
synonym: "beta1,4-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.244]
synonym: "beta1,4-N-acetylgalactosaminyltransferase III activity" EXACT [EC:2.4.1.244]
synonym: "beta1,4-N-acetylgalactosaminyltransferase IV activity" EXACT [EC:2.4.1.244]
synonym: "beta4GalNAc-T3" RELATED [EC:2.4.1.244]
synonym: "beta4GalNAc-T4" RELATED [EC:2.4.1.244]
synonym: "UDP-N-acetyl-D-galactosamine:N-acetyl-D-glucosaminyl-group beta-1,4-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.244]
xref: EC:2.4.1.244
xref: MetaCyc:2.4.1.244-RXN
xref: RHEA:20496
is_a: GO:0008376 ! acetylgalactosaminyltransferase activity

[Term]
id: GO:0033843
name: xyloglucan 6-xylosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an alpha-D-xylosyl residue from UDP-D-xylose to a glucose residue in xyloglucan, forming an alpha-1,6-D-xylosyl-D-glucose linkage." [EC:2.4.2.39]
synonym: "UDP-D-xylose:xyloglucan 1,6-alpha-D-xylosyltransferase activity" EXACT [EC:2.4.2.39]
synonym: "uridine diphosphoxylose-xyloglucan 6alpha-xylosyltransferase activity" EXACT [EC:2.4.2.39]
synonym: "xyloglucan 6-alpha-D-xylosyltransferase activity" EXACT [EC:2.4.2.39]
xref: EC:2.4.2.39
xref: MetaCyc:2.4.2.39-RXN
is_a: GO:0042285 ! xylosyltransferase activity

[Term]
id: GO:0033844
name: galactose-6-sulfurylase activity
namespace: molecular_function
def: "Catalysis of the elimination of sulfate from the D-galactose 6-sulfate residues of porphyran, producing 3,6-anhydrogalactose residues." [EC:2.5.1.5]
synonym: "D-galactose-6-sulfate:alkyltransferase (cyclizing) activity" EXACT [EC:2.5.1.5]
synonym: "galactose 6-sulfatase activity" EXACT [EC:2.5.1.5]
synonym: "galactose-6-sulfatase activity" EXACT [EC:2.5.1.5]
synonym: "porphyran sulfatase activity" EXACT [EC:2.5.1.5]
xref: EC:2.5.1.5
xref: MetaCyc:2.5.1.5-RXN
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0033845
name: hydroxymethylfurfural reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-hydroxymethylfurfural + NADPH + H+ = 2,5-bis-hydroxymethylfuran + NADP+." [GOC:jp, GOC:mah, PMID:15338422, PMID:16652391]
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033846
name: adenosyl-fluoride synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + fluoride = 5'-deoxy-5'-fluoroadenosine + L-methionine." [EC:2.5.1.63]
synonym: "fluorinase activity" EXACT [EC:2.5.1.63]
synonym: "S-adenosyl-L-methionine:fluoride adenosyltransferase activity" EXACT [EC:2.5.1.63]
xref: EC:2.5.1.63
xref: MetaCyc:2.5.1.63-RXN
xref: RHEA:16664
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0033847
name: O-phosphoserine sulfhydrylase activity
namespace: molecular_function
def: "Catalysis of the reaction: O-phospho-L-serine + hydrogen sulfide = L-cysteine + phosphate." [EC:2.5.1.65]
synonym: "O-phospho-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase activity" EXACT [EC:2.5.1.65]
synonym: "O-phosphoserine(thiol)-lyase activity" EXACT [EC:2.5.1.65]
xref: EC:2.5.1.65
xref: MetaCyc:2.5.1.65-RXN
xref: Reactome:REACT_27223 "OPS is added to the carrier sulfide, Mycobacterium tuberculosis"
xref: RHEA:10255
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0033848
name: N2-(2-carboxyethyl)arginine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + L-arginine = N(2)-(2-carboxyethyl)-L-arginine + H(+) + phosphate." [EC:2.5.1.66, RHEA:10559]
synonym: "CEA synthetase activity" EXACT [EC:2.5.1.66]
synonym: "CEAS" RELATED [EC:2.5.1.66]
synonym: "glyceraldehyde-3-phosphate:L-arginine 2-N-(2-hydroxy-3-oxopropyl) transferase (2-carboxyethyl-forming) activity" EXACT [EC:2.5.1.66]
synonym: "glyceraldehyde-3-phosphate:L-arginine N2-(2-hydroxy-3-oxopropyl) transferase (2-carboxyethyl-forming) activity" EXACT [EC:2.5.1.66]
synonym: "N2-(2-carboxyethyl)arginine synthetase activity" EXACT [EC:2.5.1.66]
xref: EC:2.5.1.66
xref: KEGG:R05465
xref: MetaCyc:2.5.1.66-RXN
xref: RHEA:10559
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0033849
name: chrysanthemyl diphosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 dimethylallyl diphosphate = (R,R)-chrysanthemyl diphosphate + diphosphate." [EC:2.5.1.67, RHEA:14012]
synonym: "CPPase activity" EXACT [EC:2.5.1.67]
synonym: "dimethylallyl-diphosphate:dimethylallyl-diphosphate dimethylallyltransferase (chrysanthemyl-diphosphate-forming) activity" EXACT [EC:2.5.1.67]
xref: EC:2.5.1.67
xref: KEGG:R08948
xref: MetaCyc:2.5.1.67-RXN
xref: RHEA:14012
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0033850
name: Z-farnesyl diphosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = 2-cis,6-trans-farnesyl diphosphate + diphosphate." [EC:2.5.1.68, RHEA:23303]
synonym: "(Z)-farnesyl diphosphate synthase activity" EXACT [EC:2.5.1.68]
synonym: "geranyl-diphosphate:isopentenyl-diphosphate geranylcistransferase activity" EXACT [EC:2.5.1.68]
xref: EC:2.5.1.68
xref: KEGG:R08528
xref: MetaCyc:2.5.1.68-RXN
xref: RHEA:23303
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0033851
name: lavandulyl diphosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 dimethylallyl diphosphate = diphosphate + lavandulyl diphosphate." [EC:2.5.1.69, RHEA:21679]
synonym: "dimethylallyl-diphosphate:dimethylallyl-diphosphate dimethylallyltransferase (lavandulyl-diphosphate-forming) activity" EXACT [EC:2.5.1.69]
synonym: "FDS-5" RELATED [EC:2.5.1.69]
xref: EC:2.5.1.69
xref: KEGG:R08950
xref: MetaCyc:2.5.1.69-RXN
xref: RHEA:21679
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0033852
name: thyroid-hormone transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + 3,5,3'-triiodo-L-thyronine = 3,5,3'-triiodothyropyruvate + L-glutamate." [EC:2.6.1.26, RHEA:19136]
synonym: "3,5-dinitrotyrosine aminotransferase activity" EXACT [EC:2.6.1.26]
synonym: "3,5-dinitrotyrosine transaminase activity" EXACT [EC:2.6.1.26]
synonym: "L-3,5,3'-triiodothyronine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.26]
synonym: "thyroid hormone aminotransferase activity" EXACT [EC:2.6.1.26]
synonym: "thyroid-hormone aminotransferase activity" EXACT [EC:2.6.1.26]
xref: EC:2.6.1.26
xref: KEGG:R03952
xref: MetaCyc:THYROID-HORMONE-AMINOTRANSFERASE-RXN
xref: RHEA:19136
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0033853
name: aspartate-prephenate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arogenate + oxaloacetate = prephenate + L-aspartate." [EC:2.6.1.78]
synonym: "L-arogenate:oxaloacetate aminotransferase activity" EXACT [EC:2.6.1.78]
synonym: "L-aspartate:prephenate aminotransferase activity" EXACT [EC:2.6.1.78]
synonym: "PAT" RELATED [EC:2.6.1.78]
synonym: "prephenate aspartate aminotransferase activity" EXACT [EC:2.6.1.78]
synonym: "prephenate transaminase activity" BROAD [EC:2.6.1.78]
xref: EC:2.6.1.78
xref: MetaCyc:PREPHENATE-ASP-TRANSAMINE-RXN
xref: RHEA:20448
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0033854
name: glutamate-prephenate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + L-arogenate = L-glutamate + prephenate." [EC:2.6.1.79, RHEA:22883]
synonym: "L-arogenate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.79]
synonym: "L-glutamate:prephenate aminotransferase activity" EXACT [EC:2.6.1.79]
synonym: "PAT" RELATED [EC:2.6.1.79]
synonym: "prephenate transaminase activity" BROAD [EC:2.6.1.79]
xref: EC:2.6.1.79
xref: KEGG:R07276
xref: MetaCyc:PREPHENATE-TRANSAMINE-RXN
xref: RHEA:22883
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0033855
name: nicotianamine aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + nicotianamine = 3''-deamino-3''-oxonicotianamine + L-glutamate." [EC:2.6.1.80, RHEA:22107]
synonym: "NAAT" RELATED [EC:2.6.1.80]
synonym: "NAAT-I" RELATED [EC:2.6.1.80]
synonym: "NAAT-II" RELATED [EC:2.6.1.80]
synonym: "NAAT-III" RELATED [EC:2.6.1.80]
synonym: "nicotianamine transaminase activity" EXACT [EC:2.6.1.80]
synonym: "nicotianamine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.80]
xref: EC:2.6.1.80
xref: KEGG:R07277
xref: MetaCyc:2.6.1.80-RXN
xref: RHEA:22107
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0033856
name: pyridoxine 5'-phosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = 2 H(2)O + H(+) + phosphate + pyridoxine 5'-phosphate." [EC:2.6.99.2, RHEA:15268]
synonym: "1-deoxy-D-xylulose-5-phosphate:3-amino-2-oxopropyl phosphate 3-amino-2-oxopropyltransferase (phosphate-hydrolysing; cyclizing) activity" EXACT [EC:2.6.99.2]
synonym: "PdxJ" RELATED [EC:2.6.99.2]
synonym: "PNP synthase activity" EXACT [EC:2.6.99.2]
synonym: "pyridoxine 5-phosphate phospho lyase activity" EXACT [EC:2.6.99.2]
xref: EC:2.6.99.2
xref: KEGG:R05838
xref: MetaCyc:PDXJ-RXN
xref: RHEA:15268
is_a: GO:0016769 ! transferase activity, transferring nitrogenous groups

[Term]
id: GO:0033857
name: diphosphoinositol-pentakisphosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 1D-myo-inositol 5-diphosphate pentakisphosphate = ADP + 1D-myo-inositol bisdiphosphate tetrakisphosphate." [EC:2.7.4.24]
synonym: "ATP:5-diphospho-1D-myo-inositol-pentakisphosphate phosphotransferase activity" EXACT [EC:2.7.4.24]
synonym: "PP-InsP5 kinase activity" EXACT [EC:2.7.4.24]
synonym: "PP-IP5 kinase activity" EXACT [EC:2.7.4.24]
synonym: "PPIP5K" RELATED [EC:2.7.4.24]
synonym: "PPIP5K1" RELATED [EC:2.7.4.24]
synonym: "PPIP5K2" RELATED [EC:2.7.4.24]
synonym: "VIP1" NARROW [EC:2.7.4.24]
synonym: "VIP2" NARROW [EC:2.7.4.24]
xref: EC:2.7.4.24
is_a: GO:0016301 ! kinase activity
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor

[Term]
id: GO:0033858
name: N-acetylgalactosamine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + N-acetyl-D-galactosamine = ADP + N-acetyl-alpha-D-galactosamine 1-phosphate." [EC:2.7.1.157]
synonym: "ATP:N-acetyl-D-galactosamine 1-phosphotransferase activity" EXACT [EC:2.7.1.157]
synonym: "GALK2" RELATED [EC:2.7.1.157]
synonym: "GalNAc kinase activity" EXACT [EC:2.7.1.157]
synonym: "GK2" RELATED [EC:2.7.1.157]
synonym: "N-acetylgalactosamine (GalNAc)-1-phosphate kinase activity" EXACT [EC:2.7.1.157]
xref: EC:2.7.1.157
xref: MetaCyc:2.7.1.157-RXN
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0033859
name: furaldehyde metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving furaldehyde, a furan ring-containing aldehyde compound which can be formed from the thermal decomposition of biomass." [GOC:jp, PMID:15338422, PMID:16652391]
is_a: GO:0006081 ! cellular aldehyde metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process

[Term]
id: GO:0033860
name: regulation of NAD(P)H oxidase activity
namespace: biological_process
def: "Any process that modulates the activity of the enzyme NAD(P)H oxidase." [GOC:mah]
is_a: GO:0051341 ! regulation of oxidoreductase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016174 ! NAD(P)H oxidase activity
relationship: regulates GO:0016174 ! NAD(P)H oxidase activity

[Term]
id: GO:0033861
name: negative regulation of NAD(P)H oxidase activity
namespace: biological_process
def: "Any process that stops or reduces the activity of the enzyme NAD(P)H oxidase." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation of NAD(P)H oxidase activity" EXACT []
synonym: "down-regulation of NAD(P)H oxidase activity" EXACT []
synonym: "downregulation of NAD(P)H oxidase activity" EXACT []
synonym: "inhibition of NAD(P)H oxidase activity" NARROW []
is_a: GO:0033860 ! regulation of NAD(P)H oxidase activity
is_a: GO:0051354 ! negative regulation of oxidoreductase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016174 ! NAD(P)H oxidase activity
relationship: negatively_regulates GO:0016174 ! NAD(P)H oxidase activity

[Term]
id: GO:0033862
name: UMP kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + UMP = ADP + UDP." [EC:2.7.4.22]
synonym: "ATP:UMP phosphotransferase activity" EXACT [EC:2.7.4.22]
synonym: "PyrH" RELATED [EC:2.7.4.22]
synonym: "SmbA" RELATED [EC:2.7.4.22]
synonym: "UMP-kinase activity" EXACT [EC:2.7.4.22]
synonym: "UMPK" RELATED [EC:2.7.4.22]
synonym: "uridine monophosphate kinase activity" EXACT [EC:2.7.4.22]
xref: EC:2.7.4.22
xref: MetaCyc:2.7.4.22-RXN
xref: RHEA:24403
is_a: GO:0009041 ! uridylate kinase activity

[Term]
id: GO:0033863
name: ribose 1,5-bisphosphate phosphokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-ribose 1,5-diphosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + ADP + H(+)." [EC:2.7.4.23, RHEA:20112]
synonym: "ATP:ribose-1,5-bisphosphate phosphotransferase activity" EXACT [EC:2.7.4.23]
synonym: "PhnN" RELATED [EC:2.7.4.23]
synonym: "ribose 1,5-bisphosphokinase activity" EXACT [EC:2.7.4.23]
xref: EC:2.7.4.23
xref: KEGG:R06836
xref: MetaCyc:2.7.4.23-RXN
xref: RHEA:20112
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0033864
name: positive regulation of NAD(P)H oxidase activity
namespace: biological_process
def: "Any process that activates or increases the activity of the enzyme NAD(P)H oxidase." [GOC:mah]
subset: gosubset_prok
synonym: "activation of NAD(P)H oxidase activity" NARROW []
synonym: "stimulation of NAD(P)H oxidase activity" NARROW []
synonym: "up regulation of NAD(P)H oxidase activity" EXACT []
synonym: "up-regulation of NAD(P)H oxidase activity" EXACT []
synonym: "upregulation of NAD(P)H oxidase activity" EXACT []
is_a: GO:0033860 ! regulation of NAD(P)H oxidase activity
is_a: GO:0051353 ! positive regulation of oxidoreductase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016174 ! NAD(P)H oxidase activity
relationship: positively_regulates GO:0016174 ! NAD(P)H oxidase activity

[Term]
id: GO:0033865
name: nucleoside bisphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a nucleoside bisphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde]
subset: gosubset_prok
synonym: "nucleoside bisphosphate metabolism" EXACT []
is_a: GO:0006753 ! nucleoside phosphate metabolic process

[Term]
id: GO:0033866
name: nucleoside bisphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a nucleoside bisphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde]
subset: gosubset_prok
synonym: "nucleoside bisphosphate anabolism" EXACT []
synonym: "nucleoside bisphosphate biosynthesis" EXACT []
synonym: "nucleoside bisphosphate formation" EXACT []
synonym: "nucleoside bisphosphatehate synthesis" EXACT []
is_a: GO:0033865 ! nucleoside bisphosphate metabolic process
is_a: GO:1901293 ! nucleoside phosphate biosynthetic process

[Term]
id: GO:0033867
name: Fas-activated serine/threonine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + Fas-activated serine/threonine protein = ADP + Fas-activated serine/threonine phosphoprotein." [EC:2.7.11.8]
synonym: "ATP:Fas-activated serine/threonine protein phosphotransferase activity" EXACT [EC:2.7.11.8]
synonym: "FAST" RELATED [EC:2.7.11.8]
synonym: "FASTK" RELATED [EC:2.7.11.8]
synonym: "STK10" RELATED [EC:2.7.11.8]
xref: EC:2.7.11.8
xref: MetaCyc:2.7.11.8-RXN
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0033868
name: Goodpasture-antigen-binding protein kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + Goodpasture antigen-binding protein = ADP + Goodpasture antigen-binding phosphoprotein." [EC:2.7.11.9]
synonym: "ATP:Goodpasture antigen-binding protein phosphotransferase activity" EXACT [EC:2.7.11.9]
synonym: "Goodpasture antigen-binding protein kinase activity" EXACT [EC:2.7.11.9]
synonym: "GPBP kinase activity" EXACT [EC:2.7.11.9]
synonym: "GPBPK" RELATED [EC:2.7.11.9]
synonym: "STK11" RELATED [EC:2.7.11.9]
xref: EC:2.7.11.9
xref: MetaCyc:2.7.11.9-RXN
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0033869
name: nucleoside bisphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a nucleoside bisphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde]
subset: gosubset_prok
synonym: "nucleoside bisphosphate breakdown" EXACT []
synonym: "nucleoside bisphosphate catabolism" EXACT []
synonym: "nucleoside bisphosphate degradation" EXACT []
is_a: GO:0033865 ! nucleoside bisphosphate metabolic process
is_a: GO:1901292 ! nucleoside phosphate catabolic process

[Term]
id: GO:0033870
name: thiol sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + a thiol = adenosine 3',5'-bisphosphate + an S-alkyl thiosulfate." [EC:2.8.2.16]
synonym: "3'-phosphoadenylyl-sulfate:thiol S-sulfotransferase activity" EXACT [EC:2.8.2.16]
synonym: "adenosine 3'-phosphate 5'-sulphatophosphate sulfotransferase activity" EXACT [EC:2.8.2.16]
synonym: "PAPS sulfotransferase activity" BROAD [EC:2.8.2.16]
xref: EC:2.8.2.16
xref: MetaCyc:THIOL-SULFOTRANSFERASE-RXN
xref: RHEA:14640
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0033871
name: [heparan sulfate]-glucosamine 3-sulfotransferase 2 activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate; modifies selected glucosamine residues preceded by GlcA2S." [EC:2.8.2.29]
synonym: "3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase activity" BROAD [EC:2.8.2.29]
synonym: "3-OST-2" RELATED [EC:2.8.2.29]
synonym: "glucosaminyl 3-O-sulfotransferase 2 activity" EXACT [EC:2.8.2.29]
synonym: "glucosaminyl 3-O-sulfotransferase activity" BROAD [EC:2.8.2.29]
synonym: "heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2 activity" EXACT [EC:2.8.2.29]
synonym: "heparan sulfate D-glucosaminyl 3-O-sulfotransferase activity" BROAD [EC:2.8.2.29]
synonym: "heparin-glucosamine 3-sulfotransferase 2 activity" RELATED []
synonym: "isoform/isozyme 2 (3-OST-2, HS3ST2)" RELATED [EC:2.8.2.29]
xref: EC:2.8.2.29
xref: MetaCyc:2.8.2.29-RXN
is_a: GO:0034483 ! heparan sulfate sulfotransferase activity

[Term]
id: GO:0033872
name: [heparan sulfate]-glucosamine 3-sulfotransferase 3 activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate." [EC:2.8.2.30]
synonym: "3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase activity" BROAD [EC:2.8.2.30]
synonym: "3-OST-3" RELATED [EC:2.8.2.30]
synonym: "glucosaminyl 3-O-sulfotransferase 3 activity" EXACT [EC:2.8.2.30]
synonym: "glucosaminyl 3-O-sulfotransferase 3a, 3b activity" EXACT [EC:2.8.2.30]
synonym: "heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3 activity" EXACT [EC:2.8.2.30]
synonym: "heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A activity" EXACT [EC:2.8.2.30]
synonym: "heparin-glucosamine 3-sulfotransferase 3 activity" RELATED []
synonym: "isoform/isozyme 3a and 3b (3-OST-3A, 3-OST-3B, HS3ST3A, HS3ST3B)" RELATED [EC:2.8.2.30]
xref: EC:2.8.2.30
xref: MetaCyc:2.8.2.30-RXN
is_a: GO:0034483 ! heparan sulfate sulfotransferase activity

[Term]
id: GO:0033873
name: petromyzonol sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + 5alpha-cholane-3alpha,7alpha,12alpha,24-tetrol = 3alpha,7alpha,12alpha-trihydroxy-5alpha-cholan-24-yl sulfate + adenosine 3',5'-diphosphate + H(+)." [EC:2.8.2.31, RHEA:17000]
synonym: "3'-phosphoadenylyl-sulfate:5alpha-cholan-3alpha,7alpha,12alpha,24-tetrol sulfotransferase activity" EXACT [EC:2.8.2.31]
synonym: "PZ-SULT" RELATED [EC:2.8.2.31]
xref: EC:2.8.2.31
xref: KEGG:R07797
xref: MetaCyc:2.8.2.31-RXN
xref: RHEA:17000
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0033874
name: scymnol sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + 5beta-scymnol = 5beta-scymnol sulfate + adenosine 3',5'-diphosphate + H(+)." [EC:2.8.2.32, RHEA:15480]
xref: EC:2.8.2.32
xref: KEGG:R07798
xref: MetaCyc:2.8.2.32-RXN
xref: RHEA:15480
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0033875
name: ribonucleoside bisphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a ribonucleoside bisphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde]
subset: gosubset_prok
synonym: "ribonucleoside bisphosphate metabolism" EXACT []
is_a: GO:0033865 ! nucleoside bisphosphate metabolic process

[Term]
id: GO:0033876
name: glycochenodeoxycholate sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + glycochenodeoxycholate = adenosine 3',5'-diphosphate + glycochenodeoxycholate 7-sulfate + H(+)." [EC:2.8.2.34, RHEA:17692]
synonym: "3'-phosphoadenylyl-sulfate:glycochenodeoxycholate 7-sulfotransferase activity" EXACT [EC:2.8.2.34]
synonym: "BAST" RELATED [EC:2.8.2.34]
synonym: "bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase activity" BROAD [EC:2.8.2.34]
synonym: "bile acid:PAPS:sulfotransferase activity" EXACT [EC:2.8.2.34]
xref: EC:2.8.2.34
xref: KEGG:R07289
xref: MetaCyc:2.8.2.34-RXN
xref: RHEA:17692
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0033877
name: succinyl-CoA:(R)-benzylsuccinate CoA-transferase activity
namespace: molecular_function
alt_id: GO:0018728
def: "Catalysis of the reaction: (R)-2-benzylsuccinate + succinyl-CoA = (R)-2-benzylsuccinyl-CoA + succinate." [EC:2.8.3.15, RHEA:16472]
synonym: "benzylsuccinate CoA-transferase activity" EXACT [EC:2.8.3.15]
synonym: "succinyl-CoA:(R)-2-benzylsuccinate CoA-transferase activity" EXACT [EC:2.8.3.15]
synonym: "succinyl-CoA:benzylsuccinate CoA-transferase activity" EXACT []
xref: EC:2.8.3.15
xref: KEGG:R05588
xref: MetaCyc:RXN-864
xref: RHEA:16472
xref: UM-BBD_reactionID:r0329
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0033878
name: hormone-sensitive lipase activity
namespace: molecular_function
def: "Catalysis of the reactions: diacylglycerol + H2O = monoacylglycerol + a carboxylate; triacylglycerol + H2O = diacylglycerol + a carboxylate; and monoacylglycerol + H2O = glycerol + a carboxylate." [EC:3.1.1.79]
synonym: "diacylglycerol acylhydrolase activity" EXACT [EC:3.1.1.79]
synonym: "HSL" RELATED [EC:3.1.1.79]
xref: EC:3.1.1.79
xref: MetaCyc:STEROL-ESTERASE-RXN
xref: MetaCyc:TRIACYLGLYCEROL-LIPASE-RXN
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0033879
name: acetylajmaline esterase activity
namespace: molecular_function
def: "Catalysis of the reactions: 17-O-acetylajmaline + H2O = ajmaline + acetate, and 17-O-acetylnorajmaline + H2O = norajmaline + acetate." [EC:3.1.1.80]
synonym: "17-O-acetylajmaline O-acetylhydrolase activity" EXACT [EC:3.1.1.80]
synonym: "2beta(R)-17-O-acetylajmalan:acetylesterase activity" EXACT [EC:3.1.1.80]
synonym: "AAE" RELATED [EC:3.1.1.80]
synonym: "acetylajmalan esterase activity" EXACT [EC:3.1.1.80]
xref: EC:3.1.1.80
xref: MetaCyc:RXN-8652
xref: MetaCyc:RXN-8653
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0033880
name: phenylacetyl-CoA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + phenylglyoxylyl-CoA = CoA + H(+) + phenylglyoxylate." [EC:3.1.2.25, RHEA:15340]
synonym: "phenylglyoxylyl-CoA hydrolase activity" EXACT [EC:3.1.2.25]
xref: EC:3.1.2.25
xref: KEGG:R07294
xref: MetaCyc:3.1.2.25-RXN
xref: RHEA:15340
is_a: GO:0016289 ! CoA hydrolase activity

[Term]
id: GO:0033881
name: bile-acid-CoA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: deoxycholoyl-CoA + H(2)O = CoA + deoxycholate + H(+)." [EC:3.1.2.26, RHEA:17696]
synonym: "bile acid-coenzyme A hydrolase activity" EXACT [EC:3.1.2.26]
synonym: "deoxycholoyl-CoA hydrolase activity" EXACT [EC:3.1.2.26]
xref: EC:3.1.2.26
xref: KEGG:R07295
xref: MetaCyc:BACOAHYDRO-RXN
xref: RHEA:17696
is_a: GO:0016289 ! CoA hydrolase activity

[Term]
id: GO:0033882
name: choloyl-CoA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: choloyl-CoA + H2O = cholate + CoA." [EC:3.1.2.27]
synonym: "chenodeoxycholoyl-coenzyme A thioesterase activity" EXACT [EC:3.1.2.27]
synonym: "choloyl-coenzyme A thioesterase activity" EXACT [EC:3.1.2.27]
synonym: "peroxisomal acyl-CoA thioesterase 2 activity" NARROW [EC:3.1.2.27]
synonym: "PTE-2" RELATED [EC:3.1.2.27]
xref: EC:3.1.2.27
xref: MetaCyc:3.1.2.27-RXN
xref: RHEA:14544
is_a: GO:0016289 ! CoA hydrolase activity

[Term]
id: GO:0033883
name: pyridoxal phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate." [EC:3.1.3.74]
synonym: "PLP phosphatase activity" EXACT [EC:3.1.3.74]
synonym: "PNP phosphatase activity" EXACT [EC:3.1.3.74]
synonym: "pyridoxal-5'-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.74]
synonym: "vitamin B6 (pyridoxine) phosphatase activity" BROAD [EC:3.1.3.74]
synonym: "vitamin B6-phosphate phosphatase activity" BROAD [EC:3.1.3.74]
xref: EC:3.1.3.74
xref: MetaCyc:3.1.3.74-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0033884
name: obsolete phosphoethanolamine/phosphocholine phosphatase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reactions: O-phosphoethanolamine + H2O = ethanolamine + phosphate, and phosphocholine + H2O = choline + phosphate." [EC:3.1.3.75]
comment: This term was made obsolete because it represents two reactions, and should be two separate terms.
synonym: "3X11A" RELATED [EC:3.1.3.75]
synonym: "PHOSPHO1" RELATED [EC:3.1.3.75]
synonym: "phosphoethanolamine phosphohydrolase activity" NARROW [EC:3.1.3.75]
synonym: "phosphoethanolamine/phosphocholine phosphatase activity" EXACT []
is_obsolete: true
consider: GO:0052731
consider: GO:0052732

[Term]
id: GO:0033885
name: 10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: (9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate + H(2)O = (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate." [EC:3.1.3.76, RHEA:16540]
synonym: "(9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity" EXACT [EC:3.1.3.76]
synonym: "(9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate phosphohydrolase activity" EXACT systematic_synonym [EC:3.1.3.76]
synonym: "dihydroxy fatty acid phosphatase activity" BROAD [EC:3.1.3.76]
synonym: "hydroxy fatty acid phosphatase activity" BROAD [EC:3.1.3.76]
synonym: "hydroxy lipid phosphatase activity" BROAD [EC:3.1.3.76]
synonym: "lipid-phosphate phosphatase activity" BROAD [EC:3.1.3.76]
synonym: "sEH" RELATED [EC:3.1.3.76]
synonym: "soluble epoxide hydrolase activity" RELATED [EC:3.1.3.76]
xref: EC:3.1.3.76
xref: KEGG:R07582
xref: MetaCyc:3.1.3.76-RXN
xref: RHEA:16540
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0033886
name: cellulose-polysulfatase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the 2- and 3-sulfate groups of the polysulfates of cellulose and charonin." [EC:3.1.6.7]
synonym: "cellulose-sulfate sulfohydrolase activity" EXACT [EC:3.1.6.7]
xref: EC:3.1.6.7
xref: MetaCyc:3.1.6.7-RXN
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0033887
name: chondro-4-sulfatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 4-sulfate + H(2)O = 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate." [EC:3.1.6.9, RHEA:11447]
synonym: "4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase activity" EXACT [EC:3.1.6.9]
xref: EC:3.1.6.9
xref: KEGG:R03517
xref: MetaCyc:CHONDRO-4-SULFATASE-RXN
xref: RHEA:11447
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0033888
name: chondro-6-sulfatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 6-sulfate + H(2)O = 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate." [EC:3.1.6.10, RHEA:10539]
synonym: "4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine-6-sulfate 6-sulfohydrolase activity" EXACT [EC:3.1.6.10]
xref: EC:3.1.6.10
xref: KEGG:R03518
xref: MetaCyc:CHONDRO-6-SULFATASE-RXN
xref: RHEA:10539
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0033889
name: N-sulfoglucosamine-3-sulfatase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the 3-sulfate groups of the N-sulfo-D-glucosamine 3-O-sulfate units of heparin." [EC:3.1.6.15]
synonym: "chondroitinsulfatase activity" BROAD [EC:3.1.6.15]
synonym: "N-sulfo-3-sulfoglucosamine 3-sulfohydrolase activity" EXACT [EC:3.1.6.15]
xref: EC:3.1.6.15
xref: MetaCyc:3.1.6.15-RXN
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0033890
name: ribonuclease D activity
namespace: molecular_function
def: "Catalysis of the exonucleolytic cleavage that removes extra residues from the 3'-terminus of tRNA to produce 5'-mononucleotides." [EC:3.1.13.5]
synonym: "RNase D activity" EXACT [EC:3.1.13.5]
xref: EC:3.1.13.5
xref: MetaCyc:3.1.13.5-RXN
is_a: GO:0016896 ! exoribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0033891
name: CC-preferring endodeoxyribonuclease activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage to give 5'-phosphooligonucleotide end-products, with a preference for cleavage within the sequence CC." [EC:3.1.21.6]
synonym: "5'-CC-3'-preferring endodeoxyribonuclease activity" EXACT [EC:3.1.21.6]
synonym: "Streptomyces glaucescens exocytoplasmic dodeoxyribonuclease activity" EXACT [EC:3.1.21.6]
synonym: "Streptomyces glaucescens exocytoplasmic endodeoxyribonuclease activity" EXACT [EC:3.1.21.6]
synonym: "Streptomyces glaucescens exocytoplasmic endonuclease activity" EXACT [EC:3.1.21.6]
xref: EC:3.1.21.6
xref: MetaCyc:3.1.21.6-RXN
is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0033892
name: deoxyribonuclease (pyrimidine dimer) activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate." [EC:3.1.25.1]
synonym: "bacteriophage T4 endodeoxyribonuclease V activity" EXACT [EC:3.1.25.1]
synonym: "endodeoxyribonuclease (pyrimidine dimer) activity" EXACT [EC:3.1.25.1]
synonym: "T4 endonuclease V activity" EXACT [EC:3.1.25.1]
xref: EC:3.1.25.1
xref: MetaCyc:3.1.25.1-RXN
is_a: GO:0016890 ! site-specific endodeoxyribonuclease activity, specific for altered base

[Term]
id: GO:0033893
name: ribonuclease IV activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of poly(A) to fragments terminated by 3'-hydroxy and 5'-phosphate groups." [EC:3.1.26.6]
synonym: "endoribonuclease IV activity" EXACT [EC:3.1.26.6]
xref: EC:3.1.26.6
xref: MetaCyc:3.1.26.6-RXN
is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0033894
name: ribonuclease P4 activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of RNA, removing 3'-extranucleotides from tRNA precursor." [EC:3.1.26.7]
xref: EC:3.1.26.7
xref: MetaCyc:3.1.26.7-RXN
is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0033895
name: ribonuclease [poly-(U)-specific] activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of poly(U) to fragments terminated by 3'-hydroxy and 5'-phosphate groups." [EC:3.1.26.9]
synonym: "ribonuclease (uracil-specific) activity" EXACT [EC:3.1.26.9]
synonym: "uracil-specific endoribonuclease activity" EXACT [EC:3.1.26.9]
synonym: "uracil-specific RNase activity" EXACT [EC:3.1.26.9]
xref: EC:3.1.26.9
is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0033896
name: ribonuclease IX activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of poly(U) or poly(C) to fragments terminated by 3'-hydroxy and 5'-phosphate groups." [EC:3.1.26.10]
synonym: "poly(U)- and poly(C)-specific endoribonuclease activity" EXACT [EC:3.1.26.10]
xref: EC:3.1.26.10
xref: MetaCyc:3.1.26.10-RXN
is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0033897
name: ribonuclease T2 activity
namespace: molecular_function
def: "Catalysis of the two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates." [EC:3.1.27.1]
synonym: "acid ribonuclease activity" EXACT [EC:3.1.27.1]
synonym: "acid RNase activity" EXACT [EC:3.1.27.1]
synonym: "base-non-specific ribonuclease activity" EXACT [EC:3.1.27.1]
synonym: "Escherichia coli ribonuclease I' ribonuclease PP2 activity" EXACT [EC:3.1.27.1]
synonym: "Escherichia coli ribonuclease II activity" EXACT [EC:3.1.27.1]
synonym: "non-base specific ribonuclease activity" EXACT [EC:3.1.27.1]
synonym: "nonbase-specific RNase activity" EXACT [EC:3.1.27.1]
synonym: "nonspecific RNase activity" EXACT [EC:3.1.27.1]
synonym: "ribonnuclease (non-base specific) activity" EXACT [EC:3.1.27.1]
synonym: "ribonuclease (non-base specific) activity" EXACT [EC:3.1.27.1]
synonym: "ribonuclease II activity" BROAD [EC:3.1.27.1]
synonym: "ribonuclease M activity" EXACT [EC:3.1.27.1]
synonym: "ribonuclease N2 activity" EXACT [EC:3.1.27.1]
synonym: "ribonuclease PP3 activity" EXACT [EC:3.1.27.1]
synonym: "ribonuclease U4 activity" EXACT [EC:3.1.27.1]
synonym: "ribonucleate 3'-oligonucleotide hydrolase activity" EXACT [EC:3.1.27.1]
synonym: "ribonucleate nucleotido-2'-transferase (cyclizing) activity" BROAD [EC:3.1.27.1]
synonym: "RNAase CL activity" EXACT [EC:3.1.27.1]
synonym: "RNase (non-base specific) activity" EXACT [EC:3.1.27.1]
synonym: "RNase II activity" BROAD [EC:3.1.27.1]
synonym: "RNase M activity" EXACT [EC:3.1.27.1]
synonym: "RNase Ms activity" EXACT [EC:3.1.27.1]
synonym: "RNase T2 activity" EXACT [EC:3.1.27.1]
xref: EC:3.1.27.1
xref: MetaCyc:3.1.27.1-RXN
is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters

[Term]
id: GO:0033898
name: Bacillus subtilis ribonuclease activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage to 2',3'-cyclic nucleotides." [EC:3.1.27.2]
synonym: "proteus mirabilis RNase activity" EXACT [EC:3.1.27.2]
synonym: "ribonucleate nucleotido-2'-transferase (cyclizing) activity" BROAD [EC:3.1.27.2]
xref: EC:3.1.27.2
xref: MetaCyc:3.1.27.2-RXN
is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters

[Term]
id: GO:0033899
name: ribonuclease U2 activity
namespace: molecular_function
def: "Catalysis of the two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in Ap or Gp with 2',3'-cyclic phosphate intermediates." [EC:3.1.27.4]
synonym: "pleospora RNase activity" EXACT [EC:3.1.27.4]
synonym: "purine specific endoribonuclease activity" EXACT [EC:3.1.27.4]
synonym: "purine-specific ribonuclease activity" EXACT [EC:3.1.27.4]
synonym: "purine-specific RNase activity" EXACT [EC:3.1.27.4]
synonym: "ribonuclease (purine) activity" EXACT [EC:3.1.27.4]
synonym: "ribonuclease U3 activity" EXACT [EC:3.1.27.4]
synonym: "RNase U3 activity" EXACT [EC:3.1.27.4]
synonym: "trichoderma koningi RNase III activity" EXACT [EC:3.1.27.4]
xref: EC:3.1.27.4
xref: MetaCyc:3.1.27.4-RXN
is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters

[Term]
id: GO:0033900
name: ribonuclease F activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of RNA precursor into two, leaving 5'-hydroxy and 3'-phosphate groups." [EC:3.1.27.7]
synonym: "ribonuclease F (E. coli) activity" EXACT [EC:3.1.27.7]
synonym: "RNase F activity" EXACT [EC:3.1.27.7]
xref: EC:3.1.27.7
xref: MetaCyc:3.1.27.7-RXN
is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters

[Term]
id: GO:0033901
name: ribonuclease V activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of poly(A), forming oligoribonucleotides and ultimately 3'-AMP." [EC:3.1.27.8]
synonym: "endoribonuclease V activity" EXACT [EC:3.1.27.8]
xref: EC:3.1.27.8
xref: MetaCyc:3.1.27.8-RXN
is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters

[Term]
id: GO:0033902
name: rRNA endonuclease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the phosphodiester linkage between guanosine and adenosine residues at one specific position in 28S rRNA from rat ribosomes." [EC:3.1.27.10]
synonym: "alpha-sarcin" RELATED [EC:3.1.27.10]
xref: EC:3.1.27.10
xref: MetaCyc:3.1.27.10-RXN
is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters

[Term]
id: GO:0033903
name: obsolete endo-1,3(4)-beta-glucanase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the endohydrolysis of 1,3- or 1,4-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolysed is itself substituted at C-3." [EC:3.2.1.6]
comment: This term was made obsolete because it was representing two different activities, for which new GO terms have now been created: GO:0052861 glucan endo-1,3-beta-glucanase activity, C-3 substituted reducing group and GO:0052862 glucan endo-1,4-beta-glucanase activity, C-3 substituted reducing group.
synonym: "1,3-(1,3;1,4)-beta-D-glucan 3(4)-glucanohydrolase activity" EXACT [EC:3.2.1.6]
synonym: "beta-1,3-1,4-glucanase activity" EXACT [EC:3.2.1.6]
synonym: "beta-1,3-glucanase activity" BROAD [EC:3.2.1.6]
synonym: "endo-1,3(4)-beta-glucanase activity" EXACT []
synonym: "endo-1,3-1,4-beta-D-glucanase activity" EXACT [EC:3.2.1.6]
synonym: "endo-1,3-beta-D-glucanase activity" BROAD [EC:3.2.1.6]
synonym: "endo-1,3-beta-glucanase activity" BROAD [EC:3.2.1.6]
synonym: "endo-1,4-beta-glucanase activity" BROAD [EC:3.2.1.6]
synonym: "endo-beta-(1,3)-D-glucanase activity" BROAD [EC:3.2.1.6]
synonym: "endo-beta-(1->3)-D-glucanase activity" BROAD [EC:3.2.1.6]
synonym: "endo-beta-1,3(4)-glucanase activity" EXACT [EC:3.2.1.6]
synonym: "endo-beta-1,3-1,4-glucanase activity" EXACT [EC:3.2.1.6]
synonym: "endo-beta-1,3-glucanase IV activity" EXACT [EC:3.2.1.6]
synonym: "laminaranase activity" BROAD [EC:3.2.1.6]
synonym: "laminarinase activity" BROAD [EC:3.2.1.6]
xref: EC:3.2.1.6
xref: MetaCyc:3.2.1.6-RXN
is_obsolete: true
consider: GO:0052861
consider: GO:0052862

[Term]
id: GO:0033904
name: dextranase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of 1,6-alpha-D-glucosidic linkages in dextran." [EC:3.2.1.11]
synonym: "1,6-alpha-D-glucan 6-glucanohydrolase activity" EXACT [EC:3.2.1.11]
synonym: "alpha-1,6-glucan-6-glucanohydrolase activity" EXACT [EC:3.2.1.11]
synonym: "alpha-D-1,6-glucan-6-glucanohydrolase activity" EXACT [EC:3.2.1.11]
synonym: "dextran hydrolase activity" EXACT [EC:3.2.1.11]
synonym: "dextranase DL 2 activity" NARROW [EC:3.2.1.11]
synonym: "DL 2" RELATED [EC:3.2.1.11]
synonym: "endo-dextranase activity" EXACT [EC:3.2.1.11]
synonym: "endodextranase activity" EXACT [EC:3.2.1.11]
xref: EC:3.2.1.11
xref: MetaCyc:3.2.1.11-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033905
name: xylan endo-1,3-beta-xylosidase activity
namespace: molecular_function
def: "Catalysis of the random hydrolysis of (1->3)-beta-D-glycosidic linkages in (1->3)-beta-D-xylans." [EC:3.2.1.32]
synonym: "1,3-beta-D-xylan xylanohydrolase activity" EXACT [EC:3.2.1.32]
synonym: "1,3-beta-xylanase activity" EXACT [EC:3.2.1.32]
synonym: "1,3-xylanase activity" EXACT [EC:3.2.1.32]
synonym: "beta-1,3-xylanase activity" EXACT [EC:3.2.1.32]
synonym: "endo-1,3-beta-xylanase activity" EXACT [EC:3.2.1.32]
synonym: "endo-1,3-xylanase activity" EXACT [EC:3.2.1.32]
synonym: "endo-beta-1,3-xylanase activity" EXACT [EC:3.2.1.32]
synonym: "xylanase activity" BROAD [EC:3.2.1.32]
xref: EC:3.2.1.32
xref: MetaCyc:3.2.1.32-RXN
is_a: GO:0097599 ! xylanase activity

[Term]
id: GO:0033906
name: hyaluronoglucuronidase activity
namespace: molecular_function
def: "Catalysis of the random hydrolysis of 1,3-linkages between beta-D-glucuronate and N-acetyl-D-glucosamine residues in hyaluronate." [EC:3.2.1.36]
synonym: "glucuronoglucosaminoglycan hyaluronate lyase activity" EXACT [EC:3.2.1.36]
synonym: "hyaluronate 3-glycanohydrolase activity" EXACT [EC:3.2.1.36]
synonym: "hyaluronidase activity" BROAD [EC:3.2.1.36]
synonym: "orgelase activity" EXACT [EC:3.2.1.36]
xref: EC:3.2.1.36
xref: MetaCyc:3.2.1.36-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033907
name: beta-D-fucosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal non-reducing beta-D-fucose residues in beta-D-fucosides." [EC:3.2.1.38]
synonym: "beta-D-fucoside fucohydrolase activity" EXACT [EC:3.2.1.38]
synonym: "beta-fucosidase activity" EXACT [EC:3.2.1.38]
xref: EC:3.2.1.38
xref: MetaCyc:3.2.1.38-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033908
name: beta-L-rhamnosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal, non-reducing beta-L-rhamnose residues in beta-L-rhamnosides." [EC:3.2.1.43]
synonym: "beta-L-rhamnoside rhamnohydrolase activity" EXACT [EC:3.2.1.43]
xref: EC:3.2.1.43
xref: MetaCyc:3.2.1.43-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033909
name: fucoidanase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of 1,2-alpha-L-fucoside linkages in fucoidan without release of sulfate." [EC:3.2.1.44]
synonym: "poly(1,2-alpha-L-fucoside-4-sulfate) glycanohydrolase activity" EXACT [EC:3.2.1.44]
xref: EC:3.2.1.44
xref: MetaCyc:3.2.1.44-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033910
name: glucan 1,4-alpha-maltotetraohydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1->4)-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltotetraose residues from the non-reducing chain ends." [EC:3.2.1.60]
synonym: "1,4-alpha-D-glucan maltotetraohydrolase activity" EXACT [EC:3.2.1.60]
synonym: "exo-maltotetraohydrolase activity" EXACT [EC:3.2.1.60]
synonym: "G4-amylase activity" EXACT [EC:3.2.1.60]
synonym: "glucan 1,4-alpha-maltotetrahydrolase activity" EXACT [EC:3.2.1.60]
synonym: "maltotetraose-forming amylase activity" EXACT [EC:3.2.1.60]
xref: EC:3.2.1.60
xref: MetaCyc:3.2.1.60-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033911
name: mycodextranase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of 1,4-alpha-D-glucosidic linkages in alpha-D-glucans containing both 1,3- and 1,4-bonds." [EC:3.2.1.61]
synonym: "1,3-1,4-alpha-D-glucan 4-glucanohydrolase activity" EXACT [EC:3.2.1.61]
xref: EC:3.2.1.61
xref: MetaCyc:3.2.1.61-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033912
name: 2,6-beta-fructan 6-levanbiohydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (2->6)-beta-D-fructofuranan, to remove successive disaccharide residues as levanbiose, i.e. 6-(beta-D-fructofuranosyl)-D-fructose, from the end of the chain." [EC:3.2.1.64]
synonym: "2,6-beta-D-fructan 6-beta-D-fructofuranosylfructohydrolase activity" EXACT [EC:3.2.1.64]
synonym: "2,6-beta-D-fructan 6-levanbiohydrolase activity" EXACT [EC:3.2.1.64]
synonym: "2,6-beta-D-fructofuranan 6-(beta-D-fructosyl)-D-fructose-hydrolase activity" EXACT [EC:3.2.1.64]
synonym: "beta-2,6-fructan-6-levanbiohydrolase activity" EXACT [EC:3.2.1.64]
synonym: "levanbiose-producing levanase activity" EXACT [EC:3.2.1.64]
xref: EC:3.2.1.64
xref: MetaCyc:3.2.1.64-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033913
name: glucan endo-1,2-beta-glucosidase activity
namespace: molecular_function
def: "Catalysis of the random hydrolysis of (1->2)-glucosidic linkages in (1->2)-beta-D-glucans." [EC:3.2.1.71]
synonym: "1,2-beta-D-glucan glucanohydrolase activity" EXACT [EC:3.2.1.71]
synonym: "beta-D-1,2-glucanase activity" EXACT [EC:3.2.1.71]
synonym: "endo-(1->2)-beta-D-glucanase activity" EXACT [EC:3.2.1.71]
synonym: "endo-1,2-beta-glucanase activity" EXACT [EC:3.2.1.71]
xref: EC:3.2.1.71
xref: MetaCyc:3.2.1.71-RXN
is_a: GO:0008422 ! beta-glucosidase activity

[Term]
id: GO:0033914
name: xylan 1,3-beta-xylosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of successive xylose residues from the non-reducing termini of (1->3)-beta-D-xylans." [EC:3.2.1.72]
synonym: "1,3-beta-D-xylan xylohydrolase activity" EXACT [EC:3.2.1.72]
synonym: "1,3-beta-D-xylosidase, exo-1,3-beta-xylosidase activity" EXACT [EC:3.2.1.72]
synonym: "beta-1,3'-xylanase activity" EXACT [EC:3.2.1.72]
synonym: "exo-1,3-beta-xylosidase activity" EXACT [EC:3.2.1.72]
synonym: "exo-beta-1,3'-xylanase activity" EXACT [EC:3.2.1.72]
xref: EC:3.2.1.72
xref: MetaCyc:3.2.1.72-RXN
is_a: GO:0097599 ! xylanase activity

[Term]
id: GO:0033915
name: mannan 1,2-(1,3)-alpha-mannosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1->2) and (1->3) linkages in mannan, releasing mannose." [EC:3.2.1.77]
synonym: "1,2-1,3-alpha-D-mannan mannohydrolase activity" EXACT [EC:3.2.1.77]
synonym: "exo-1,2-1,3-alpha-mannosidase activity" EXACT [EC:3.2.1.77]
xref: EC:3.2.1.77
xref: MetaCyc:3.2.1.77-RXN
is_a: GO:0004559 ! alpha-mannosidase activity

[Term]
id: GO:0033916
name: beta-agarase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1->4)-beta-D-galactosidic linkages in agarose, giving the tetramer as the predominant product." [EC:3.2.1.81]
synonym: "AgaA" RELATED [EC:3.2.1.81]
synonym: "AgaB" RELATED [EC:3.2.1.81]
synonym: "agarase activity" BROAD [EC:3.2.1.81]
synonym: "agarose 3-glycanohydrolase activity" BROAD [EC:3.2.1.81]
synonym: "agarose 4-glycanohydrolase activity" EXACT [EC:3.2.1.81]
xref: EC:3.2.1.81
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033917
name: exo-poly-alpha-galacturonosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of pectic acid from the non-reducing end, releasing digalacturonate." [EC:3.2.1.82]
synonym: "exopolygalacturanosidase activity" EXACT [EC:3.2.1.82]
synonym: "exopolygalacturonosidase activity" EXACT [EC:3.2.1.82]
xref: EC:3.2.1.82
xref: MetaCyc:3.2.1.82-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033918
name: kappa-carrageenase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of 1,4-beta-D-linkages between D-galactose 4-sulfate and 3,6-anhydro-D-galactose in kappa-carrageenans." [EC:3.2.1.83]
synonym: "kappa-carrageenan 4-beta-D-glycanohydrolase (configuration-retaining) activity" EXACT [EC:3.2.1.83]
synonym: "kappa-carrageenan 4-beta-D-glycanohydrolase activity" EXACT [EC:3.2.1.83]
xref: EC:3.2.1.83
xref: MetaCyc:3.2.1.83-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033919
name: glucan 1,3-alpha-glucosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal (1->3)-alpha-D-glucosidic links in 1,3-alpha-D-glucans." [EC:3.2.1.84]
synonym: "1,3-alpha-D-glucan 3-glucohydrolase activity" EXACT [EC:3.2.1.84]
synonym: "exo-1,3-alpha-glucanase activity" EXACT [EC:3.2.1.84]
synonym: "glucosidase II activity" RELATED [EC:3.2.1.84, GOC:vw]
xref: EC:3.2.1.84
xref: MetaCyc:3.2.1.84-RXN
xref: Reactome:REACT_23791 "Removal of the third glucose by glucosidase II and release from the chaperone, Homo sapiens"
xref: Reactome:REACT_23850 "Removal of the second glucose by glucosidase II, Homo sapiens"
is_a: GO:0090600 ! alpha-1,3-glucosidase activity

[Term]
id: GO:0033920
name: 6-phospho-beta-galactosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 6-phospho-beta-D-galactoside + H2O = 6-phospho-D-galactose + an alcohol." [EC:3.2.1.85]
synonym: "6-phospho-beta-D-galactosidase activity" EXACT [EC:3.2.1.85]
synonym: "6-phospho-beta-D-galactoside 6-phosphogalactohydrolase activity" EXACT [EC:3.2.1.85]
synonym: "beta-D-phosphogalactoside galactohydrolase activity" EXACT [EC:3.2.1.85]
synonym: "phospho-beta-D-galactosidase activity" EXACT [EC:3.2.1.85]
synonym: "phospho-beta-galactosidase activity" EXACT [EC:3.2.1.85]
xref: EC:3.2.1.85
xref: MetaCyc:6-PHOSPHO-BETA-GALACTOSIDASE-RXN
is_a: GO:0015925 ! galactosidase activity

[Term]
id: GO:0033921
name: capsular-polysaccharide endo-1,3-alpha-galactosidase activity
namespace: molecular_function
def: "Catalysis of the random hydrolysis of (1->3)-alpha-D-galactosidic linkages in Aerobacter aerogenes capsular polysaccharide." [EC:3.2.1.87]
synonym: "aerobacter-capsular-polysaccharide galactohydrolase activity" EXACT [EC:3.2.1.87]
synonym: "capsular polysaccharide galactohydrolase activity" EXACT [EC:3.2.1.87]
synonym: "polysaccharide depolymerase activity" EXACT [EC:3.2.1.87]
xref: EC:3.2.1.87
xref: MetaCyc:3.2.1.87-RXN
is_a: GO:0015925 ! galactosidase activity

[Term]
id: GO:0033922
name: peptidoglycan beta-N-acetylmuramidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal, non-reducing N-acetylmuramic residues." [EC:3.2.1.92]
synonym: "beta-2-acetamido-3-O-(D-1-carboxyethyl)-2-deoxy-D-glucoside acetamidodeoxyglucohydrolase activity" EXACT [EC:3.2.1.92]
synonym: "exo-beta-acetylmuramidase activity" EXACT [EC:3.2.1.92]
synonym: "exo-beta-N-acetylmuramidase activity" EXACT [EC:3.2.1.92]
synonym: "peptidoglycan beta-N-acetylmuramoylexohydrolase activity" EXACT [EC:3.2.1.92]
xref: EC:3.2.1.92
xref: MetaCyc:3.2.1.92-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033923
name: glucan 1,6-alpha-isomaltosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in polysaccharides, to remove successive isomaltose units from the non-reducing ends of the chains." [EC:3.2.1.94]
synonym: "1,6-alpha-D-glucan isomaltohydrolase activity" EXACT [EC:3.2.1.94]
synonym: "exo-isomaltohydrolase activity" EXACT [EC:3.2.1.94]
synonym: "G2-dextranase activity" EXACT [EC:3.2.1.94]
synonym: "isomalto-dextranase activity" EXACT [EC:3.2.1.94]
synonym: "isomaltodextranase activity" EXACT [EC:3.2.1.94]
xref: EC:3.2.1.94
xref: MetaCyc:3.2.1.94-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033924
name: dextran 1,6-alpha-isomaltotriosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in dextrans, to remove successive isomaltotriose units from the non-reducing ends of the chains." [EC:3.2.1.95]
synonym: "1,6-alpha-D-glucan isomaltotriohydrolase activity" EXACT [EC:3.2.1.95]
synonym: "exo-isomaltotriohydrolase activity" EXACT [EC:3.2.1.95]
xref: EC:3.2.1.95
xref: MetaCyc:3.2.1.95-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033925
name: mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of the N,N'-diacetylchitobiosyl unit in high-mannose glycopeptides and glycoproteins containing the -[Man(GlcNAc)2]Asn-structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact." [EC:3.2.1.96]
synonym: "di-N-acetylchitobiosyl beta-N-acetylglucosaminidase activity" EXACT [EC:3.2.1.96]
synonym: "endo-beta-(1->4)-N-acetylglucosaminidase activity" EXACT [EC:3.2.1.96]
synonym: "endo-beta-acetylglucosaminidase activity" EXACT [EC:3.2.1.96]
synonym: "endo-beta-N-acetylglucosaminidase activity" EXACT [EC:3.2.1.96]
synonym: "endo-beta-N-acetylglucosaminidase D activity" EXACT [EC:3.2.1.96]
synonym: "endo-beta-N-acetylglucosaminidase F activity" EXACT [EC:3.2.1.96]
synonym: "endo-beta-N-acetylglucosaminidase H activity" EXACT [EC:3.2.1.96]
synonym: "endo-beta-N-acetylglucosaminidase L activity" EXACT [EC:3.2.1.96]
synonym: "endo-N-acetyl-beta-D-glucosaminidase activity" EXACT [EC:3.2.1.96]
synonym: "endo-N-acetyl-beta-glucosaminidase activity" EXACT [EC:3.2.1.96]
synonym: "endoglycosidase H activity" EXACT [EC:3.2.1.96]
synonym: "endoglycosidase S activity" EXACT [EC:3.2.1.96]
synonym: "glycopeptide-D-mannosyl-4-N-(N-acetyl-D-glucosaminyl)2-asparagine 1,4-N-acetyl-beta-glucosaminohydrolase activity" EXACT [EC:3.2.1.96]
synonym: "glycopeptide-D-mannosyl-N4-(N-acetyl-D-glucosaminyl)2-asparagine 1,4-N-acetyl-beta-glucosaminohydrolase activity" EXACT [EC:3.2.1.96]
synonym: "mannosyl-glycoprotein 1,4-N-acetamidodeoxy-beta-D-glycohydrolase activity" EXACT [EC:3.2.1.96]
synonym: "mannosyl-glycoprotein endo-beta-N-acetylglucosamidase activity" EXACT [EC:3.2.1.96]
synonym: "N,N'-diacetylchitobiosyl beta-N-acetylglucosaminidase activity" EXACT [EC:3.2.1.96]
xref: EC:3.2.1.96
xref: MetaCyc:3.2.1.96-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033926
name: glycopeptide alpha-N-acetylgalactosaminidase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-galactosyl-3-(N-acetyl-alpha-D-galactosaminyl)-L-serine + H2O = D-galactosyl-3-N-acetyl-alpha-D-galactosamine + L-serine." [EC:3.2.1.97, MetaCyc:3.2.1.97-RXN]
synonym: "D-galactosyl-N-acetyl-alpha-D-galactosamine D-galactosyl-N-acetyl-galactosaminohydrolase activity" EXACT [EC:3.2.1.97]
synonym: "endo-alpha-acetylgalactosaminidase activity" BROAD [EC:3.2.1.97]
synonym: "endo-alpha-N-acetylgalactosaminidase activity" BROAD [EC:3.2.1.97]
xref: EC:3.2.1.97
xref: MetaCyc:3.2.1.97-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033927
name: glucan 1,4-alpha-maltohexaosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1->4)-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltohexaose residues from the non-reducing chain ends." [EC:3.2.1.98]
synonym: "1,4-alpha-D-glucan maltohexaohydrolase activity" EXACT [EC:3.2.1.98]
synonym: "exo-maltohexaohydrolase activity" EXACT [EC:3.2.1.98]
synonym: "G6-amylase activity" EXACT [EC:3.2.1.98]
synonym: "maltohexaose-producing amylase activity" EXACT [EC:3.2.1.98]
xref: EC:3.2.1.98
xref: MetaCyc:3.2.1.98-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033928
name: mannan 1,4-mannobiosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1->4)-beta-D-mannosidic linkages in (1->4)-beta-D-mannans, to remove successive mannobiose residues from the non-reducing chain ends." [EC:3.2.1.100]
synonym: "1,4-beta-D-mannan mannobiohydrolase activity" BROAD [EC:3.2.1.100]
synonym: "exo-1,4-beta-mannobiohydrolase activity" EXACT [EC:3.2.1.100]
synonym: "exo-beta-mannanase activity" EXACT [EC:3.2.1.100]
synonym: "mannan 1,4-beta-mannobiosidase activity" EXACT [EC:3.2.1.100]
xref: EC:3.2.1.100
xref: MetaCyc:3.2.1.100-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033929
name: blood-group-substance endo-1,4-beta-galactosidase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of (1->4)-beta-D-galactosidic linkages in blood group A and B substances." [EC:3.2.1.102]
synonym: "blood-group-substance 1,4-beta-D-galactanohydrolase activity" EXACT [EC:3.2.1.102]
synonym: "endo-beta-galactosidase activity" BROAD [EC:3.2.1.102]
xref: EC:3.2.1.102
xref: MetaCyc:3.2.1.102-RXN
is_a: GO:0015925 ! galactosidase activity

[Term]
id: GO:0033930
name: keratan-sulfate endo-1,4-beta-galactosidase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of (1->4)-beta-D-galactosidic linkages in keratan sulfate." [EC:3.2.1.103]
synonym: "endo-beta-galactosidase activity" BROAD [EC:3.2.1.103]
synonym: "keratan sulfate endogalactosidase activity" EXACT [EC:3.2.1.103]
synonym: "keratan-sulfate 1,4-beta-D-galactanohydrolase activity" EXACT [EC:3.2.1.103]
synonym: "keratanase activity" EXACT [EC:3.2.1.103]
xref: EC:3.2.1.103
xref: MetaCyc:3.2.1.103-RXN
is_a: GO:0015925 ! galactosidase activity

[Term]
id: GO:0033931
name: endogalactosaminidase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of (1->4)-alpha-D-galactosaminidic linkages in poly(D-galactosamine)." [EC:3.2.1.109]
synonym: "galactosaminoglycan glycanohydrolase activity" EXACT [EC:3.2.1.109]
xref: EC:3.2.1.109
xref: MetaCyc:3.2.1.109-RXN
is_a: GO:0015929 ! hexosaminidase activity

[Term]
id: GO:0033932
name: 1,3-alpha-L-fucosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1->3) linkages between alpha-L-fucose and N-acetylglucosamine residues in glycoproteins." [EC:3.2.1.111]
synonym: "3-alpha-L-fucosyl-N-acetylglucosaminyl-glycoprotein fucohydrolase activity" EXACT [EC:3.2.1.111]
synonym: "almond emulsin fucosidase I activity" EXACT [EC:3.2.1.111]
xref: EC:3.2.1.111
xref: MetaCyc:3.2.1.111-RXN
is_a: GO:0004560 ! alpha-L-fucosidase activity

[Term]
id: GO:0033933
name: branched-dextran exo-1,2-alpha-glucosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1->2)-alpha-D-glucosidic linkages at the branch points of dextrans and related polysaccharides, producing free D-glucose." [EC:3.2.1.115]
synonym: "1,2-alpha-D-glucosyl-branched-dextran 2-glucohydrolase activity" EXACT [EC:3.2.1.115]
synonym: "dextran 1,2-alpha-glucosidase activity" EXACT [EC:3.2.1.115]
synonym: "dextran alpha-1,2 debranching enzyme" RELATED [EC:3.2.1.115]
xref: EC:3.2.1.115
xref: MetaCyc:3.2.1.115-RXN
is_a: GO:0015926 ! glucosidase activity

[Term]
id: GO:0033934
name: glucan 1,4-alpha-maltotriohydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1->4)-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltotriose residues from the non-reducing chain ends." [EC:3.2.1.116]
synonym: "1,4-alpha-D-glucan maltotriohydrolase activity" EXACT [EC:3.2.1.116]
synonym: "exo-maltotriohydrolase activity" EXACT [EC:3.2.1.116]
synonym: "maltotriohydrolase activity" EXACT [EC:3.2.1.116]
xref: EC:3.2.1.116
xref: MetaCyc:3.2.1.116-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033935
name: oligoxyloglucan beta-glycosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1->4)-beta-D-glucosidic links in oligoxyloglucans so as to remove successive isoprimeverose (i.e. alpha-xylo-1,6-beta-D-glucosyl-) residues from the non-reducing chain ends." [EC:3.2.1.120]
synonym: "isoprimeverose-producing oligoxyloglucan hydrolase activity" EXACT [EC:3.2.1.120]
synonym: "oligoxyloglucan hydrolase activity" EXACT [EC:3.2.1.120]
synonym: "oligoxyloglucan xyloglucohydrolase activity" EXACT [EC:3.2.1.120]
xref: EC:3.2.1.120
xref: MetaCyc:3.2.1.120-RXN
is_a: GO:0008422 ! beta-glucosidase activity

[Term]
id: GO:0033936
name: polymannuronate hydrolase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of the D-mannuronide linkages of polymannuronate." [EC:3.2.1.121]
synonym: "poly(mannuronide) mannuronohydrolase activity" EXACT [EC:3.2.1.121]
synonym: "polymannuronic acid polymerase activity" EXACT [EC:3.2.1.121]
xref: EC:3.2.1.121
xref: MetaCyc:3.2.1.121-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033937
name: 3-deoxy-2-octulosonidase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of the beta-ketopyranosidic linkages of 3-deoxy-D-manno-2-octulosonate in capsular polysaccharides." [EC:3.2.1.124]
synonym: "2-keto-3-deoxyoctonate hydrolase activity" EXACT [EC:3.2.1.124]
synonym: "capsular-polysaccharide 3-deoxy-D-manno-2-octulosonohydrolase activity" EXACT [EC:3.2.1.124]
synonym: "octulofuranosylono hydrolase activity" EXACT [EC:3.2.1.124]
synonym: "octulopyranosylonohydrolase activity" EXACT [EC:3.2.1.124]
synonym: "octulosylono hydrolase activity" EXACT [EC:3.2.1.124]
xref: EC:3.2.1.124
xref: MetaCyc:3.2.1.124-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033938
name: 1,6-alpha-L-fucosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1->6) linkages between alpha-L-fucose and N-acetyl-D-glucosamine in glycopeptides such as immunoglobulin G glycopeptide and fucosyl-asialo-agalacto-fetuin." [EC:3.2.1.127]
synonym: "1,6-L-fucosyl-N-acetyl-D-glucosaminylglycopeptide fucohydrolase activity" EXACT [EC:3.2.1.127]
xref: EC:3.2.1.127
xref: MetaCyc:3.2.1.127-RXN
is_a: GO:0004560 ! alpha-L-fucosidase activity

[Term]
id: GO:0033939
name: xylan alpha-1,2-glucuronosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of alpha-D-(1->2)-(4-O-methyl)glucuronosyl links in the main chain of hardwood xylans." [EC:3.2.1.131]
synonym: "1,2-alpha-glucuronidase activity" EXACT [EC:3.2.1.131]
synonym: "alpha-(1->2)-glucuronidase activity" EXACT [EC:3.2.1.131]
synonym: "xylan alpha-D-1,2-(4-O-methyl)glucuronohydrolase activity" EXACT [EC:3.2.1.131]
xref: EC:3.2.1.131
xref: MetaCyc:3.2.1.131-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033940
name: glucuronoarabinoxylan endo-1,4-beta-xylanase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of (1->4)-beta-D-xylosyl links in some glucuronoarabinoxylans." [EC:3.2.1.136]
synonym: "endoarabinoxylanase activity" EXACT [EC:3.2.1.136]
synonym: "feraxan endoxylanase activity" EXACT [EC:3.2.1.136]
synonym: "feraxanase activity" EXACT [EC:3.2.1.136]
synonym: "glucuronoarabinoxylan 1,4-beta-D-xylanohydrolase activity" EXACT [EC:3.2.1.136]
synonym: "glucuronoxylan xylanohydrolase activity" EXACT [EC:3.2.1.136]
synonym: "glucuronoxylan xylohydrolase activity" EXACT [EC:3.2.1.136]
synonym: "glucuronoxylanase activity" EXACT [EC:3.2.1.136]
xref: EC:3.2.1.136
xref: MetaCyc:3.2.1.136-RXN
is_a: GO:0097599 ! xylanase activity

[Term]
id: GO:0033941
name: mannan exo-1,2-1,6-alpha-mannosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1->2)-alpha-D- and (1->6)-alpha-D- linkages in mannan, releasing D-mannose." [EC:3.2.1.137]
synonym: "1,2-1,6-alpha-D-mannan D-mannohydrolase activity" EXACT [EC:3.2.1.137]
synonym: "exo-1,2-1,6-alpha-mannosidase activity" EXACT [EC:3.2.1.137]
xref: EC:3.2.1.137
xref: MetaCyc:3.2.1.137-RXN
is_a: GO:0004559 ! alpha-mannosidase activity

[Term]
id: GO:0033942
name: 4-alpha-D-\{(1->4)-alpha-D-glucano}trehalose trehalohydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of alpha-(1->4)-D-glucosidic linkage in 4-alpha-D-{(1->4)-alpha-D-glucanosyl}n trehalose to yield trehalose and alpha-(1->4)-D-glucan." [EC:3.2.1.141]
synonym: "4-alpha-D-{(1,4)-alpha-D-glucano}trehalose glucanohydrolase (trehalose-producing) activity" EXACT [EC:3.2.1.141]
synonym: "4-alpha-D-{(1->4)-alpha-D-glucano}trehalose glucanohydrolase (trehalose-producing) activity" EXACT [EC:3.2.1.141]
synonym: "malto-oligosyltrehalose trehalohydrolase activity" EXACT [EC:3.2.1.141]
synonym: "maltooligosyl trehalose trehalohydrolase activity" EXACT [EC:3.2.1.141]
xref: EC:3.2.1.141
xref: MetaCyc:3.2.1.141-RXN
xref: Reactome:REACT_27171 "Glucanotrehalose is hydrolyzed to 1,4-alpha-glucan and trehalose, Mycobacterium tuberculosis"
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033943
name: galactan 1,3-beta-galactosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in (1->3)-beta-D-galactopyranans." [EC:3.2.1.145]
synonym: "galactan (1,3)-beta-D-galactosidase activity" EXACT [EC:3.2.1.145]
synonym: "galactan (1->3)-beta-D-galactosidase activity" EXACT [EC:3.2.1.145]
xref: EC:3.2.1.145
xref: MetaCyc:3.2.1.145-RXN
is_a: GO:0015925 ! galactosidase activity

[Term]
id: GO:0033944
name: beta-galactofuranosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal non-reducing beta-D-galactofuranosides, releasing galactose." [EC:3.2.1.146]
synonym: "beta-D-galactofuranosidase activity" EXACT [EC:3.2.1.146]
synonym: "beta-D-galactofuranoside hydrolase activity" EXACT [EC:3.2.1.146]
synonym: "exo-beta-D-galactofuranosidase activity" EXACT [EC:3.2.1.146]
synonym: "exo-beta-galactofuranosidase activity" EXACT [EC:3.2.1.146]
xref: EC:3.2.1.146
xref: MetaCyc:3.2.1.146-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033945
name: oligoxyloglucan reducing-end-specific cellobiohydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of cellobiose from the reducing end of xyloglucans consisting of a beta-(1->4) linked glucan carrying alpha-D-xylosyl groups on O-6 of the glucose residues. To be a substrate, the first residue must be unsubstituted, the second residue may bear a xylosyl group, whether further glycosylated or not, and the third residue, which becomes the new terminus by the action of the enzyme, is preferably xylosylated, but this xylose residue must not be further substituted." [EC:3.2.1.150]
synonym: "oligoxyloglucan reducing end-specific cellobiohydrolase activity" EXACT [EC:3.2.1.150]
synonym: "oligoxyloglucan reducing-end cellobiohydrolase activity" EXACT [EC:3.2.1.150]
xref: EC:3.2.1.150
xref: MetaCyc:3.2.1.150-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033946
name: xyloglucan-specific endo-beta-1,4-glucanase activity
namespace: molecular_function
def: "Catalysis of the reaction: xyloglucan + H2O = xyloglucan oligosaccharides. This reaction is the endohydrolysis of (1->4)-beta-D-glucosidic linkages in xyloglucan." [EC:3.2.1.151]
synonym: "1,4-beta-D-glucan glucanohydrolase activity" BROAD [EC:3.2.1.151]
synonym: "[(1->6)-beta-D-xylo]-(1->4)-beta-D-glucan glucanohydrolase activity" EXACT [EC:3.2.1.151]
synonym: "XEG" RELATED [EC:3.2.1.151]
synonym: "XH" RELATED [EC:3.2.1.151]
synonym: "xyloglucan endo-beta-1,4-glucanase activity" EXACT [EC:3.2.1.151]
synonym: "xyloglucanase activity" EXACT [EC:3.2.1.151]
synonym: "xyloglucanendohydrolase activity" EXACT [EC:3.2.1.151]
xref: EC:3.2.1.151
xref: MetaCyc:3.2.1.151-RXN
is_a: GO:0052736 ! beta-glucanase activity

[Term]
id: GO:0033947
name: mannosylglycoprotein endo-beta-mannosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the alpha-D-mannosyl-(1->6)-beta-D-mannosyl-(1->4)-beta-D-N-acetylglucosaminyl-(1->4)-beta-D-N-acetylglucosaminyl sequence of glycoprotein to alpha-D-mannosyl-(1->6)-D-mannose and beta-D-N-acetylglucosaminyl-(1->4)-beta-D-N-acetylglucosaminyl sequences." [EC:3.2.1.152]
synonym: "endo-beta-mannosidase activity" EXACT [EC:3.2.1.152]
xref: EC:3.2.1.152
xref: MetaCyc:3.2.1.152-RXN
is_a: GO:0004567 ! beta-mannosidase activity

[Term]
id: GO:0033948
name: fructan beta-(2,1)-fructosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal, non-reducing (2->1) linked beta-D-fructofuranose residues in fructans." [EC:3.2.1.153]
synonym: "1-FEH II" RELATED [EC:3.2.1.153]
synonym: "1-FEH w1" RELATED [EC:3.2.1.153]
synonym: "1-FEH w2" RELATED [EC:3.2.1.153]
synonym: "1-fructan exohydrolase activity" EXACT [EC:3.2.1.153]
synonym: "beta-(2,1)-D-fructan fructohydrolase activity" EXACT [EC:3.2.1.153]
synonym: "beta-(2,1)-fructan exohydrolase activity" EXACT [EC:3.2.1.153]
synonym: "beta-(2,1)-linkage-specific fructan-beta-fructosidase activity" EXACT [EC:3.2.1.153]
xref: EC:3.2.1.153
xref: MetaCyc:3.2.1.153-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033949
name: fructan beta-(2,6)-fructosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal, non-reducing (2->6) linked beta-D-fructofuranose residues in fructans." [EC:3.2.1.154]
synonym: "6-FEH" RELATED [EC:3.2.1.154]
synonym: "beta-(2,6)-D-fructan fructohydrolase activity" EXACT [EC:3.2.1.154]
synonym: "beta-(2,6)-fructan exohydrolase activity" EXACT [EC:3.2.1.154]
xref: EC:3.2.1.154
xref: MetaCyc:3.2.1.154-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033950
name: xyloglucan-specific exo-beta-1,4-glucanase activity
namespace: molecular_function
def: "Catalysis of the reaction: xyloglucan + H2O = xyloglucan oligosaccharides. This reaction is the exohydrolysis of 1,4-beta-D-glucosidic linkages in xyloglucan." [EC:3.2.1.155]
synonym: "[(1->6)-alpha-D-xylo]-(1->4)-beta-D-glucan exo-glucohydrolase activity" EXACT [EC:3.2.1.155]
synonym: "Cel74A" RELATED [EC:3.2.1.155]
xref: EC:3.2.1.155
xref: MetaCyc:3.2.1.155-RXN
is_a: GO:0052736 ! beta-glucanase activity

[Term]
id: GO:0033951
name: oligosaccharide reducing-end xylanase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of 1,4-beta-D-xylose residues from the reducing end of oligosaccharides." [EC:3.2.1.156]
synonym: "beta-D-xylopyranosyl-(1->4)-beta-D-xylopyranosyl-(1->4)-beta-D-xylopyranose reducing-end xylanase activity" EXACT [EC:3.2.1.156]
synonym: "reducing end xylose-releasing exo-oligoxylanase activity" EXACT [EC:3.2.1.156]
synonym: "Rex" RELATED [EC:3.2.1.156]
xref: EC:3.2.1.156
xref: MetaCyc:3.2.1.156-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033952
name: iota-carrageenase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of 1,4-beta-D-linkages between D-galactose 4-sulfate and 3,6-anhydro-D-galactose-2-sulfate in iota-carrageenans." [EC:3.2.1.157]
synonym: "iota-carrageenan 4-beta-D-glycanohydrolase (configuration-inverting) activity" EXACT [EC:3.2.1.157]
xref: EC:3.2.1.157
xref: MetaCyc:3.2.1.157-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033953
name: alpha-agarase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of 1,3-alpha-L-galactosidic linkages in agarose, yielding agarotetraose as the major product." [EC:3.2.1.158]
synonym: "agarase A33 activity" NARROW [EC:3.2.1.158]
synonym: "agarase activity" BROAD [EC:3.2.1.158]
synonym: "agarose 3-glycanohydrolase activity" BROAD [EC:3.2.1.158]
xref: EC:3.2.1.158
xref: MetaCyc:3.2.1.158-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033954
name: alpha-neoagaro-oligosaccharide hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the 1,3-alpha-L-galactosidic linkages of neoagaro-oligosaccharides that are smaller than a hexamer, yielding 3,6-anhydro-L-galactose and D-galactose." [EC:3.2.1.159]
synonym: "alpha-NAOS hydrolase activity" EXACT [EC:3.2.1.159]
synonym: "alpha-neoagaro-oligosaccharide 3-glycohydrolase activity" EXACT [EC:3.2.1.159]
synonym: "alpha-neoagarooligosaccharide hydrolase activity" EXACT [EC:3.2.1.159]
xref: EC:3.2.1.159
xref: MetaCyc:3.2.1.159-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033955
name: mitochondrial DNA inheritance
namespace: biological_process
alt_id: GO:0090142
def: "The process in which copies of the mitochondrial genome are distributed into daughter mitochondria upon mitochondrial fission." [GOC:mah]
synonym: "mitochondrial chromosome segregation" RELATED []
synonym: "mitochondrial DNA segregation" RELATED []
is_a: GO:0000002 ! mitochondrial genome maintenance
relationship: part_of GO:0000266 ! mitochondrial fission

[Term]
id: GO:0033956
name: beta-apiosyl-beta-glucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7-[beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranosyloxy]isoflavonoid + H2O = a 7-hydroxyisoflavonoid + beta-D-apiofuranosyl-(1->6)-D-glucose." [EC:3.2.1.161]
synonym: "7-[beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranosyloxy]isoflavonoid beta-D-apiofuranosyl-(1->6)-D-glucohydrolase activity" EXACT [EC:3.2.1.161]
synonym: "furcatin hydrolase activity" EXACT [EC:3.2.1.161]
synonym: "isoflavonoid 7-O-beta-apiosyl-glucoside beta-glucosidase activity" EXACT [EC:3.2.1.161]
synonym: "isoflavonoid-7-O-beta[D-apiosyl-(1->6)-beta-D-glucoside] disaccharidase activity" EXACT [EC:3.2.1.161]
xref: EC:3.2.1.161
xref: MetaCyc:3.2.1.161-RXN
xref: MetaCyc:RXN-9156
is_a: GO:0008422 ! beta-glucosidase activity

[Term]
id: GO:0033957
name: lambda-carrageenase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of beta-1,4-linkages in the backbone of lambda-carrageenan, resulting in the tetrasaccharide alpha-D-Galp2,6S2-(1->3)-beta-D-Galp2S-(1->4)-alpha-D-Galp2,6S2-(1->3)-D-Galp2S." [EC:3.2.1.162]
synonym: "endo-beta-1,4-carrageenose 2,6,2'-trisulfate-hydrolase activity" EXACT [EC:3.2.1.162]
xref: EC:3.2.1.162
xref: MetaCyc:3.2.1.162-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033958
name: DNA-deoxyinosine glycosylase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of DNA and polynucleotides, releasing free hypoxanthine." [EC:3.2.2.15]
synonym: "deoxyribonucleic acid glycosylase activity" EXACT [EC:3.2.2.15]
synonym: "DNA(hypoxanthine) glycohydrolase activity" EXACT [EC:3.2.2.15]
synonym: "DNA-deoxyinosine deoxyribohydrolase activity" EXACT [EC:3.2.2.15]
synonym: "DNA-deoxyinosine glycosidase activity" EXACT [EC:3.2.2.15]
synonym: "hypoxanthine-DNA glycosylase activity" EXACT [EC:3.2.2.15]
xref: EC:3.2.2.15
xref: MetaCyc:3.2.2.15-RXN
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0033959
name: deoxyribodipyrimidine endonucleosidase activity
namespace: molecular_function
def: "Catalysis of the cleavage of the N-glycosidic bond between the 5'-pyrimidine residue in cyclobutadipyrimidine (in DNA) and the corresponding deoxy-D-ribose residue." [EC:3.2.2.17]
synonym: "deoxy-D-ribocyclobutadipyrimidine polynucleotidodeoxyribohydrolase activity" EXACT [EC:3.2.2.17]
synonym: "deoxyribonucleate pyrimidine dimer glycosidase activity" EXACT [EC:3.2.2.17]
synonym: "endonuclease V activity" BROAD [EC:3.2.2.17]
synonym: "PD-DNA glycosylase activity" EXACT [EC:3.2.2.17]
synonym: "pyrimidine dimer DNA glycosylase activity" EXACT [EC:3.2.2.17]
synonym: "pyrimidine dimer DNA-glycosylase activity" EXACT [EC:3.2.2.17]
synonym: "T4-induced UV endonuclease activity" EXACT [EC:3.2.2.17]
xref: EC:3.2.2.17
xref: MetaCyc:3.2.2.17-RXN
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0033960
name: N-methyl nucleosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7-methylxanthosine + H(2)O = 7-methylxanthine + H(+) + ribofuranose." [EC:3.2.2.25, RHEA:10883]
synonym: "7-methylxanthosine nucleosidase activity" EXACT [EC:3.2.2.25]
synonym: "7-methylxanthosine ribohydrolase activity" EXACT [EC:3.2.2.25]
synonym: "methylpurine nucleosidase activity" EXACT [EC:3.2.2.25]
synonym: "N-MeNase activity" EXACT [EC:3.2.2.25]
synonym: "N-methyl nucleoside hydrolase activity" EXACT [EC:3.2.2.25]
xref: EC:3.2.2.25
xref: KEGG:R07918
xref: MetaCyc:RXN-7597
xref: RHEA:10883
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0033961
name: cis-stilbene-oxide hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-stilbene oxide + H2O = (+)-(1R,2R)-1,2-diphenylethane-1,2-diol." [EC:3.3.2.9]
subset: goslim_chembl
synonym: "arene-oxide hydratase activity" BROAD [EC:3.3.2.9]
synonym: "aryl epoxide hydrase activity" BROAD [EC:3.3.2.9]
synonym: "benzo(a)pyrene-4,5-epoxide hydratase activity" NARROW [EC:3.3.2.9]
synonym: "benzo[a]pyrene-4,5-oxide hydratase activity" NARROW [EC:3.3.2.9]
synonym: "cis-epoxide hydrolase activity" EXACT [EC:3.3.2.9]
synonym: "epoxide hydrase activity" BROAD [EC:3.3.2.9]
synonym: "epoxide hydratase activity" BROAD [EC:3.3.2.9]
synonym: "mEH" RELATED [EC:3.3.2.9]
synonym: "microsomal epoxide hydrase activity" NARROW [EC:3.3.2.9]
synonym: "microsomal epoxide hydratase activity" NARROW [EC:3.3.2.9]
synonym: "microsomal epoxide hydrolase activity" NARROW [EC:3.3.2.9]
xref: EC:3.3.2.9
xref: MetaCyc:3.3.2.9-RXN
xref: RHEA:23903
is_a: GO:0016803 ! ether hydrolase activity

[Term]
id: GO:0033962
name: cytoplasmic mRNA processing body assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body." [GOC:mah, PMID:17429074]
synonym: "P body assembly" EXACT []
synonym: "P body biogenesis" RELATED []
synonym: "P-body assembly" EXACT []
is_a: GO:0022618 ! ribonucleoprotein complex assembly
is_a: GO:0070925 ! organelle assembly

[Term]
id: GO:0033963
name: cholesterol-5,6-oxide hydrolase activity
namespace: molecular_function
def: "Catalysis of the reactions: 5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O = cholestane-3beta-5alpha,6beta-triol, and 5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O = cholestane-3beta-5alpha,6beta-triol." [EC:3.3.2.11]
synonym: "5,6alpha-epoxy-5alpha-cholestan-3beta-ol hydrolase activity" EXACT [EC:3.3.2.11]
synonym: "ChEH" RELATED [EC:3.3.2.11]
synonym: "cholesterol-epoxide hydrolase activity" EXACT [EC:3.3.2.11]
xref: EC:3.3.2.11
xref: MetaCyc:RXN-8650
xref: MetaCyc:RXN-8651
is_a: GO:0016803 ! ether hydrolase activity

[Term]
id: GO:0033964
name: glycosphingolipid deacylase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of gangliosides and neutral glycosphingolipids, releasing fatty acids to form the lyso-derivatives." [EC:3.5.1.69]
synonym: "glycosphingolipid amidohydrolase activity" EXACT [EC:3.5.1.69]
synonym: "glycosphingolipid ceramide deacylase activity" BROAD [EC:3.5.1.69]
xref: EC:3.5.1.69
xref: MetaCyc:3.5.1.69-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0033965
name: aculeacin-A deacylase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the amide bond in aculeacin A and related neutral lipopeptide antibiotics, releasing the long-chain fatty acid side-chain." [EC:3.5.1.70]
synonym: "aculeacin A acylase activity" EXACT [EC:3.5.1.70]
synonym: "aculeacin-A amidohydrolase activity" EXACT [EC:3.5.1.70]
xref: EC:3.5.1.70
xref: MetaCyc:3.5.1.70-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0033966
name: N-substituted formamide deformylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-benzylformamide + H2O = formate + benzylamine." [EC:3.5.1.91]
synonym: "N-benzylformamide amidohydrolase activity" EXACT [EC:3.5.1.91]
synonym: "NfdA" RELATED [EC:3.5.1.91]
xref: MetaCyc:3.5.1.91-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0033967
name: box C/D snoRNA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving box C/D type small nucleolar RNA." [GOC:mah]
is_a: GO:0016074 ! snoRNA metabolic process

[Term]
id: GO:0033968
name: glutaryl-7-aminocephalosporanic-acid acylase activity
namespace: molecular_function
def: "Catalysis of the reaction: (7R)-7-(4-carboxybutanamido)cephalosporanate + H2O = (7R)-7-aminocephalosporanate + glutarate." [EC:3.5.1.93]
synonym: "(7R)-7-(4-carboxybutanamido)cephalosporanate amidohydrolase activity" EXACT [EC:3.5.1.93]
synonym: "7beta-(4-carboxybutanamido)cephalosporanic acid acylase activity" EXACT [EC:3.5.1.93]
synonym: "CA" RELATED [EC:3.5.1.93]
synonym: "cephalosporin acylase activity" EXACT [EC:3.5.1.93]
synonym: "cephalosporin C acylase activity" EXACT [EC:3.5.1.93]
synonym: "GA" RELATED [EC:3.5.1.93]
synonym: "GCA" RELATED [EC:3.5.1.93]
synonym: "GL-7-ACA acylase activity" EXACT [EC:3.5.1.93]
synonym: "glutaryl-7-ACA acylase activity" EXACT [EC:3.5.1.93]
synonym: "glutaryl-7-aminocephalosporanic acid acylase activity" EXACT [EC:3.5.1.93]
xref: EC:3.5.1.93
xref: MetaCyc:3.5.1.93-RXN
xref: RHEA:23511
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0033969
name: gamma-glutamyl-gamma-aminobutyrate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-(L-gamma-glutamylamino)butanoate + H(2)O = 4-aminobutanoate + L-glutamate." [EC:3.5.1.94, RHEA:19740]
synonym: "4-(glutamylamino)butanoate amidohydrolase activity" EXACT [EC:3.5.1.94]
synonym: "gamma-glutamyl-GABA hydrolase activity" EXACT [EC:3.5.1.94]
synonym: "PuuD" RELATED [EC:3.5.1.94]
synonym: "YcjL" RELATED [EC:3.5.1.94]
xref: EC:3.5.1.94
xref: KEGG:R07419
xref: MetaCyc:RXN0-3942
xref: RHEA:19740
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0033970
name: N-malonylurea hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-oxo-3-ureidopropanoate + H(2)O = H(+) + malonate + urea." [EC:3.5.1.95, RHEA:17364]
synonym: "3-oxo-3-ureidopropanoate amidohydrolase (urea- and malonate-forming) activity" EXACT [EC:3.5.1.95]
synonym: "ureidomalonase activity" EXACT [EC:3.5.1.95]
xref: EC:3.5.1.95
xref: KEGG:R07629
xref: MetaCyc:3.5.1.95-RXN
xref: RHEA:17364
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0033971
name: hydroxyisourate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-hydroxyisourate + H(2)O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)." [EC:3.5.2.17, RHEA:23739]
synonym: "5-hydroxyisourate amidohydrolase activity" EXACT [EC:3.5.2.17]
synonym: "5-hydroxyisourate hydrolase activity" EXACT [EC:3.5.2.17]
synonym: "HIUHase activity" EXACT [EC:3.5.2.17]
xref: EC:3.5.2.17
xref: KEGG:R06601
xref: MetaCyc:3.5.2.17-RXN
xref: RHEA:23739
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0033972
name: proclavaminate amidinohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: amidinoproclavaminate + H(2)O = proclavaminate + urea." [EC:3.5.3.22, RHEA:17004]
synonym: "PAH" RELATED [EC:3.5.3.22]
synonym: "proclavaminate amidino hydrolase activity" EXACT [EC:3.5.3.22]
synonym: "proclavaminic acid amidino hydrolase activity" EXACT [EC:3.5.3.22]
xref: EC:3.5.3.22
xref: KEGG:R05357
xref: MetaCyc:3.5.3.22-RXN
xref: RHEA:17004
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0033973
name: dCTP deaminase (dUMP-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: dCTP + 2 H(2)O = diphosphate + dUMP + H(+) + NH(4)(+)." [EC:3.5.4.30, RHEA:19208]
synonym: "dCTP aminohydrolase (dUMP-forming) activity" EXACT [EC:3.5.4.30]
xref: EC:3.5.4.30
xref: KEGG:R07307
xref: MetaCyc:3.5.4.30-RXN
xref: RHEA:19208
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0033974
name: nucleoside phosphoacylhydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of mixed phospho-anhydride bonds." [EC:3.6.1.24]
synonym: "nucleoside-5'-phosphoacylate acylhydrolase activity" EXACT [EC:3.6.1.24]
xref: EC:3.6.1.24
xref: MetaCyc:3.6.1.24-RXN
is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

[Term]
id: GO:0033975
name: (R)-2-haloacid dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-2-haloacid + H2O = (S)-2-hydroxyacid + halide." [EC:3.8.1.9]
synonym: "(R)-2-haloacid halidohydrolase activity" EXACT [EC:3.8.1.9]
synonym: "2-haloalkanoic acid dehalogenase activity" BROAD [EC:3.8.1.9]
synonym: "2-haloalkanoid acid halidohydrolase activity" BROAD [EC:3.8.1.9]
synonym: "D-2-haloacid dehalogenase activity" EXACT [EC:3.8.1.9]
synonym: "D-DEX" RELATED [EC:3.8.1.9]
xref: EC:3.8.1.9
xref: MetaCyc:3.8.1.9-RXN
is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds

[Term]
id: GO:0033976
name: 2-haloacid dehalogenase (configuration-inverting) activity
namespace: molecular_function
def: "Catalysis of the reactions: (S)-2-haloacid + H2O = (R)-2-hydroxyacid + halide, and (R)-2-haloacid + H2O = (S)-2-hydroxyacid + halide." [EC:3.8.1.10]
synonym: "2-haloalkanoic acid dehalogenase activity" BROAD [EC:3.8.1.10]
synonym: "2-haloalkanoid acid halidohydrolase activity" BROAD [EC:3.8.1.10]
synonym: "DL-2-haloacid dehalogenase (inversion of configuration) activity" EXACT [EC:3.8.1.10]
synonym: "DL-2-haloacid dehalogenase activity" BROAD [EC:3.8.1.10]
synonym: "DL-2-haloacid halidohydrolase (inversion of configuration) activity" EXACT [EC:3.8.1.10]
synonym: "DL-DEXi" RELATED [EC:3.8.1.10]
xref: EC:3.8.1.10
xref: MetaCyc:3.8.1.10-RXN
is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds

[Term]
id: GO:0033977
name: 2-haloacid dehalogenase (configuration-retaining) activity
namespace: molecular_function
def: "Catalysis of the reactions: (S)-2-haloacid + H2O = (S)-2-hydroxyacid + halide, and (R)-2-haloacid + H2O = (R)-2-hydroxyacid + halide." [EC:3.8.1.11]
synonym: "2-haloalkanoic acid dehalogenase activity" BROAD [EC:3.8.1.11]
synonym: "2-haloalkanoid acid halidohydrolase activity" BROAD [EC:3.8.1.11]
synonym: "DL-2-haloacid dehalogenase activity" BROAD [EC:3.8.1.11]
synonym: "DL-DEXr" RELATED [EC:3.8.1.11]
xref: EC:3.8.1.11
xref: MetaCyc:3.8.1.11-RXN
is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds

[Term]
id: GO:0033978
name: phosphonopyruvate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-phosphonopyruvate + H(2)O = phosphate + pyruvate." [EC:3.11.1.3, RHEA:16676]
synonym: "PPH" RELATED [EC:3.11.1.3]
xref: EC:3.11.1.3
xref: KEGG:R08200
xref: MetaCyc:3.11.1.3-RXN
xref: RHEA:16676
is_a: GO:0016827 ! hydrolase activity, acting on acid carbon-phosphorus bonds

[Term]
id: GO:0033979
name: box H/ACA snoRNA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving box H/ACA type small nucleolar RNA." [GOC:mah]
is_a: GO:0016074 ! snoRNA metabolic process

[Term]
id: GO:0033980
name: phosphonopyruvate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-phosphonopyruvate + 2 H(+) = CO(2) + phosphonoacetaldehyde." [EC:4.1.1.82, RHEA:20771]
synonym: "3-phosphonopyruvate carboxy-lyase (2-phosphonoacetaldehyde-forming) activity" EXACT [EC:4.1.1.82]
synonym: "3-phosphonopyruvate carboxy-lyase activity" EXACT [EC:4.1.1.82]
xref: EC:4.1.1.82
xref: KEGG:R04053
xref: MetaCyc:4.1.1.82-RXN
xref: RHEA:20771
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0033981
name: D-dopachrome decarboxylase activity
namespace: molecular_function
alt_id: GO:0030928
def: "Catalysis of the reaction: D-dopachrome + H(+) = 5,6-dihydroxyindole + CO(2)." [EC:4.1.1.84, RHEA:18444]
synonym: "D-dopachrome carboxy-lyase (5,6-dihydroxyindole-forming) activity" EXACT [EC:4.1.1.84]
synonym: "D-dopachrome carboxy-lyase activity" EXACT [EC:4.1.1.84]
synonym: "D-dopachrome tautomerase activity" EXACT [EC:4.1.1.84]
synonym: "D-tautomerase activity" EXACT [EC:4.1.1.84]
synonym: "dopachrome conversion activity" BROAD []
synonym: "dopachrome decarboxylase activity" EXACT []
synonym: "phenylpyruvate tautomerase II activity" EXACT [EC:4.1.1.84]
xref: EC:4.1.1.84
xref: KEGG:R07313
xref: MetaCyc:4.1.1.84-RXN
xref: RHEA:18444
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0033982
name: 3-dehydro-L-gulonate-6-phosphate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-dehydro-L-gulonate 6-phosphate + H(+) = L-xylulose 5-phosphate + CO(2)." [EC:4.1.1.85, RHEA:14356]
synonym: "3-dehydro-L-gulonate-6-phosphate carboxy-lyase (L-xylulose-5-phosphate-forming) activity" EXACT [EC:4.1.1.85]
synonym: "3-dehydro-L-gulonate-6-phosphate carboxy-lyase activity" EXACT [EC:4.1.1.85]
synonym: "3-keto-L-gulonate 6-phosphate decarboxylase activity" EXACT [EC:4.1.1.85]
synonym: "KGPDC" RELATED [EC:4.1.1.85]
synonym: "SgaH" RELATED [EC:4.1.1.85]
synonym: "SgbH" RELATED [EC:4.1.1.85]
synonym: "UlaD" RELATED [EC:4.1.1.85]
xref: EC:4.1.1.85
xref: KEGG:R07125
xref: MetaCyc:RXN0-705
xref: RHEA:14356
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0033983
name: diaminobutyrate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-2,4-diaminobutyrate + H(+) = 1,3-diaminopropane + CO(2)." [EC:4.1.1.86, RHEA:15692]
synonym: "DABA DC" RELATED [EC:4.1.1.86]
synonym: "L-2,4-diaminobutanoate carboxy-lyase (propane-1,3-diamine-forming) activity" EXACT [EC:4.1.1.86]
synonym: "L-2,4-diaminobutanoate carboxy-lyase activity" EXACT [EC:4.1.1.86]
synonym: "L-2,4-diaminobutyrate decarboxylase activity" EXACT [EC:4.1.1.86]
xref: EC:4.1.1.86
xref: KEGG:R07650
xref: MetaCyc:4.1.1.86-RXN
xref: RHEA:15692
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0033984
name: indole-3-glycerol-phosphate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = indole + D-glyceraldehyde 3-phosphate." [EC:4.1.2.8]
synonym: "(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate D-glyceraldehyde-3-phosphate-lyase (indole-forming) activity" EXACT [EC:4.1.2.8]
synonym: "(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate D-glyceraldehyde-3-phosphate-lyase activity" EXACT [EC:4.1.2.8]
synonym: "BX1" RELATED [EC:4.1.2.8]
synonym: "IGL" RELATED [EC:4.1.2.8]
synonym: "indole glycerol phosphate hydrolase activity" EXACT [EC:4.1.2.8]
synonym: "indole synthase activity" EXACT [EC:4.1.2.8]
synonym: "indole-3-glycerol phosphate lyase activity" EXACT [EC:4.1.2.8]
synonym: "indole-3-glycerolphosphate D-glyceraldehyde-3-phosphate-lyase activity" EXACT [EC:4.1.2.8]
synonym: "indoleglycerolphosphate aldolase activity" EXACT [EC:4.1.2.8]
synonym: "tryptophan synthase alpha activity" NARROW [EC:4.1.2.8]
synonym: "tryptophan synthase alpha subunit activity" NARROW [EC:4.1.2.8]
synonym: "TSA" RELATED [EC:4.1.2.8]
xref: EC:4.1.2.8
xref: KEGG:R02340
xref: MetaCyc:4.1.2.8-RXN
xref: MetaCyc:RXN0-2381
xref: RHEA:14084
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0033985
name: acidocalcisome lumen
namespace: cellular_component
def: "The volume enclosed by the membranes of an acidocalcisome." [GOC:mah]
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0070013 ! intracellular organelle lumen
relationship: part_of GO:0020022 ! acidocalcisome

[Term]
id: GO:0033986
name: response to methanol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methanol stimulus." [GOC:sl]
is_a: GO:0001101 ! response to acid chemical
is_a: GO:0097305 ! response to alcohol

[Term]
id: GO:0033987
name: 2-hydroxyisoflavanone dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,7,4'-trihydroxyisoflavanone = daidzein + H2O." [EC:4.2.1.105]
synonym: "2,7,4'-trihydroxyisoflavanone hydro-lyase (daidzein-forming) activity" EXACT [EC:4.2.1.105]
synonym: "2,7,4'-trihydroxyisoflavanone hydro-lyase activity" EXACT [EC:4.2.1.105]
xref: EC:4.2.1.105
xref: MetaCyc:RXN-3284
xref: RHEA:16448
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0033988
name: bile-acid 7alpha-dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oate = 12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + H(2)O." [EC:4.2.1.106, RHEA:10439]
synonym: "7alpha,12alpha-dihydroxy-3-oxochol-4-enoate hydro-lyase (12alpha-hydroxy-3-oxochola-4,6-dienoate-forming) activity" EXACT [EC:4.2.1.106]
synonym: "7alpha,12alpha-dihydroxy-3-oxochol-4-enoate hydro-lyase activity" EXACT [EC:4.2.1.106]
synonym: "BA7 alpha dehydratase activity" EXACT [EC:4.2.1.106]
xref: EC:4.2.1.106
xref: KEGG:R07318
xref: MetaCyc:4.2.1.106-RXN
xref: RHEA:10439
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0033989
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA + H2O." [EC:4.2.1.107]
synonym: "(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA hydro-lyase [(24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA-forming] activity" EXACT [EC:4.2.1.107]
synonym: "(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.107]
synonym: "46 kDa hydratase 2 activity" EXACT [EC:4.2.1.107]
synonym: "D-3-hydroxyacyl-CoA dehydratase activity" BROAD [EC:4.2.1.107]
xref: EC:4.2.1.107
xref: MetaCyc:4.2.1.107-RXN
xref: Reactome:REACT_10019 "25(S) 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA, Homo sapiens"
xref: Reactome:REACT_100366 "25(S) 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA, Taeniopygia guttata"
xref: Reactome:REACT_100547 "25(S) 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA, Mus musculus"
xref: Reactome:REACT_102889 "25(S) 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA, Saccharomyces cerevisiae"
xref: Reactome:REACT_104162 "25(S) 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA, Gallus gallus"
xref: Reactome:REACT_104672 "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA, Danio rerio"
xref: Reactome:REACT_105755 "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA, Rattus norvegicus"
xref: Reactome:REACT_106279 "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA, Dictyostelium discoideum"
xref: Reactome:REACT_108955 "25(S) 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA, Drosophila melanogaster"
xref: Reactome:REACT_30461 "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA, Taeniopygia guttata"
xref: Reactome:REACT_31730 "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA, Arabidopsis thaliana"
xref: Reactome:REACT_81704 "25(S) 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA, Dictyostelium discoideum"
xref: Reactome:REACT_83028 "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA, Bos taurus"
xref: Reactome:REACT_83112 "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA, Gallus gallus"
xref: Reactome:REACT_83438 "25(S) 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA, Bos taurus"
xref: Reactome:REACT_84136 "25(S) 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA, Caenorhabditis elegans"
xref: Reactome:REACT_85514 "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA, Xenopus tropicalis"
xref: Reactome:REACT_86632 "25(S) 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA, Canis familiaris"
xref: Reactome:REACT_87526 "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA, Canis familiaris"
xref: Reactome:REACT_88140 "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA, Saccharomyces cerevisiae"
xref: Reactome:REACT_88510 "25(S) 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA, Arabidopsis thaliana"
xref: Reactome:REACT_92774 "25(S) 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA, Danio rerio"
xref: Reactome:REACT_92834 "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA, Caenorhabditis elegans"
xref: Reactome:REACT_93111 "25(S) 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA, Xenopus tropicalis"
xref: Reactome:REACT_93290 "25(S) 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA, Oryza sativa"
xref: Reactome:REACT_93513 "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA, Oryza sativa"
xref: Reactome:REACT_93923 "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA, Mus musculus"
xref: Reactome:REACT_95150 "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA, Drosophila melanogaster"
xref: Reactome:REACT_96122 "25(S) 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA, Rattus norvegicus"
xref: Reactome:REACT_9952 "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA, Homo sapiens"
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0033990
name: ectoine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: N(4)-acetyl-L-2,4-diaminobutyrate = ectoine + H(2)O." [EC:4.2.1.108, RHEA:17284]
synonym: "4-N-acetyl-L-2,4-diaminobutanoate hydro-lyase (L-ectoine-forming) activity" EXACT [EC:4.2.1.108]
synonym: "EctC" RELATED [EC:4.2.1.108]
synonym: "L-ectoine synthase activity" EXACT [EC:4.2.1.108]
synonym: "N-acetyldiaminobutanoate dehydratase activity" EXACT [EC:4.2.1.108]
synonym: "N-acetyldiaminobutyrate dehydratase activity" EXACT [EC:4.2.1.108]
synonym: "N4-acetyl-L-2,4-diaminobutanoate hydro-lyase (L-ectoine-forming) activity" EXACT [EC:4.2.1.108]
xref: EC:4.2.1.108
xref: KEGG:R06979
xref: MetaCyc:R103-RXN
xref: RHEA:17284
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0033991
name: aldos-2-ulose dehydratase activity
namespace: molecular_function
def: "Catalysis of the reactions: 1,5-anhydro-D-fructose = 2-hydroxy-2-(hydroxymethyl)-2H-pyran-3(6H)-one + H2O; (1a) 1,5-anhydro-D-fructose = 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose + H2O and (1b) 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose = 2-hydroxy-2-(hydroxymethyl)-2H-pyran-3(6H)-one." [EC:4.2.1.110]
synonym: "1,5-anhydro-D-fructose dehydratase (microthecin-forming) activity" EXACT [EC:4.2.1.110]
synonym: "1,5-anhydro-D-fructose hydro-lyase (microthecin-forming) activity" EXACT [EC:4.2.1.110]
synonym: "AUDH" RELATED [EC:4.2.1.110]
synonym: "pyranosone dehydratase activity" EXACT [EC:4.2.1.110]
xref: EC:4.2.1.110
xref: MetaCyc:4.2.1.110-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0033992
name: 1,5-anhydro-D-fructose dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,5-anhydro-D-fructose = 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose + H2O." [EC:4.2.1.111]
synonym: "1,5-anhydro-D-arabino-hex-2-ulose dehydratase activity" EXACT [EC:4.2.1.111]
synonym: "1,5-anhydro-D-fructose 4-dehydratase activity" EXACT [EC:4.2.1.111]
synonym: "1,5-anhydro-D-fructose hydro-lyase (ascopyrone-M-forming) activity" EXACT [EC:4.2.1.111]
synonym: "1,5-anhydro-D-fructose hydro-lyase activity" EXACT [EC:4.2.1.111]
synonym: "1,5-anhydro-D-fructose hydrolyase activity" EXACT [EC:4.2.1.111]
synonym: "AF dehydratase activity" EXACT [EC:4.2.1.111]
synonym: "AFDH" RELATED [EC:4.2.1.111]
xref: EC:4.2.1.111
xref: MetaCyc:4.2.1.111-RXN
xref: RHEA:15728
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0033993
name: response to lipid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus." [GOC:sl]
is_a: GO:0010033 ! response to organic substance

[Term]
id: GO:0033994
name: glucuronan lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: (1->4)-beta-D-glucuronan = an oligosaccharide with 4-deoxy-beta-D-gluc-4-enuronosyl end + (1->4)-beta-D-glucuronan. This reaction is the eliminative cleavage of (1->4)-beta-D-glucuronans to give oligosaccharides with 4-deoxy-beta-D-gluc-4-enuronosyl groups at their non-reducing ends. Complete degradation of glucuronans results in the formation of tetrasaccharides." [EC:4.2.2.14]
synonym: "(1,4)-beta-D-glucuronan lyase activity" EXACT [EC:4.2.2.14]
xref: EC:4.2.2.14
xref: MetaCyc:4.2.2.14-RXN
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0033995
name: anhydrosialidase activity
namespace: molecular_function
def: "Catalysis of the reaction: an N-acetylneuraminate glycoside = 2,7-anhydro-alpha-N-acetylneuraminate + an alpha-sialyl group. This reaction is the elimination of alpha-sialyl groups in N-acetylneuraminic acid glycosides, releasing 2,7-anhydro-alpha-N-acetylneuraminate." [EC:4.2.2.15]
synonym: "anhydroneuraminidase activity" EXACT [EC:4.2.2.15]
synonym: "glycoconjugate sialyl-lyase (2,7-cyclizing) activity" EXACT [EC:4.2.2.15]
synonym: "sialglycoconjugate N-acylneuraminylhydrolase (2,7-cyclizing) activity" EXACT [EC:4.2.2.15]
synonym: "sialidase L activity" EXACT [EC:4.2.2.15]
xref: EC:4.2.2.15
xref: MetaCyc:4.2.2.15-RXN
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0033996
name: levan fructotransferase (DFA-IV-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-D-fructopyranosyl-(2->6)-[D-fructofuranosyl-(2->6)]n-D-fructofuranoside = beta-D-fructopyranosyl-(2->6)-[D-fructofuranosyl-(2->6)](n-1)-D-fructofuranoside + di-beta-D-fructofuranose 2,6':2',6-dianhydride. This reaction is the production of di-beta-D-fructofuranose 2,6':2',6-dianhydride (DFA IV) by successively eliminating the diminishing (2->6)-beta-D-fructan (levan) chain from the terminal D-fructosyl-D-fructosyl disaccharide." [EC:4.2.2.16]
synonym: "2,6-beta-D-fructan D-fructosyl-D-fructosyltransferase (forming di-beta-D-fructofuranose 2,6':2',6-dianhydride) activity" EXACT [EC:4.2.2.16]
synonym: "2,6-beta-D-fructan lyase (di-beta-D-fructofuranose-2,6':2',6-dianhydride-forming) activity" EXACT [EC:4.2.2.16]
synonym: "levan fructotransferase activity" EXACT [EC:4.2.2.16]
xref: EC:4.2.2.16
xref: MetaCyc:4.2.2.16-RXN
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0033997
name: inulin fructotransferase (DFA-I-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: [(2->1)-beta-D-fructosyl](n) = [(2->1)-beta-D-fructosyl](n-1) + alpha-D-fructofuranose-beta-D-fructofuranose 1,2':1,2'-dianhydride. This reaction is the production of alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,1'-dianhydride (DFA I) by successively eliminating the diminishing (2->1)-beta-D-fructan (inulin) chain from the terminal D-fructosyl-D-fructosyl disaccharide." [EC:4.2.2.17]
synonym: "2,1-beta-D-fructan lyase (alpha-D-fructofuranose-beta-D-fructofuranose-1,2':2,1'-dianhydride-forming) activity" EXACT [EC:4.2.2.17]
synonym: "inulin D-fructosyl-D-fructosyltransferase (1,2':1',2-dianhydride-forming) activity" EXACT [EC:4.2.2.17]
synonym: "inulin D-fructosyl-D-fructosyltransferase (forming alpha-D-fructofuranose beta-D-fructofuranose 1,2':1',2-dianhydride) activity" EXACT [EC:4.2.2.17]
synonym: "inulin fructotransferase (depolymerizing, difructofuranose-1,2':2',1-dianhydride-forming) activity" EXACT [EC:4.2.2.17]
synonym: "inulin fructotransferase (DFA-I-producing) activity" EXACT [EC:4.2.2.17]
xref: EC:4.2.2.17
xref: MetaCyc:4.2.2.17-RXN
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0033998
name: inulin fructotransferase (DFA-III-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: [(2->1)-beta-D-fructosyl](n) = [(2->1)-beta-D-fructosyl](n-1) + alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,3'-dianhydride. This reaction is the production of alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,3'-dianhydride (DFA III) by successively eliminating the diminishing (2->1)-beta-D-fructan (inulin) chain from the terminal D-fructosyl-D-fructosyl disaccharide." [EC:4.2.2.18]
synonym: "2,1-beta-D-fructan lyase (alpha-D-fructofuranose-beta-D-fructofuranose-1,2':2,3'-dianhydride-forming) activity" EXACT [EC:4.2.2.18]
synonym: "inulase II activity" EXACT [EC:4.2.2.18]
synonym: "inulin D-fructosyl-D-fructosyltransferase (1,2':2,3'-dianhydride-forming) activity" EXACT [EC:4.2.2.18]
synonym: "inulin D-fructosyl-D-fructosyltransferase (forming alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,3'-dianhydride) activity" EXACT [EC:4.2.2.18]
synonym: "inulin fructotransferase (depolymerizing) activity" EXACT [EC:4.2.2.18]
synonym: "inulin fructotransferase (depolymerizing, difructofuranose-1,2':2,3'-dianhydride-forming) activity" EXACT [EC:4.2.2.18]
synonym: "inulin fructotransferase (DFA-III-producing) activity" EXACT [EC:4.2.2.18]
synonym: "inulinase II activity" EXACT [EC:4.2.2.18]
xref: EC:4.2.2.18
xref: MetaCyc:4.2.2.18-RXN
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0033999
name: chondroitin B lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: dermatan sulfate = n 4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine 4-sulfate. This reaction is the eliminative cleavage of dermatan sulfate containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucurosonyl or 1,3-alpha-L-iduronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups to yield a 4,5-unsaturated dermatan-sulfate disaccharide (DeltaUA-GalNAC-4S). Chondroitin sulfate B is also known as dermatan sulfate." [EC:4.2.2.19]
synonym: "ChnB" RELATED [EC:4.2.2.19]
synonym: "chonB" RELATED [EC:4.2.2.19]
synonym: "chondroitinase B activity" EXACT [EC:4.2.2.19]
synonym: "dermatan sulfate lyase activity" EXACT []
xref: EC:4.2.2.19
xref: MetaCyc:4.2.2.19-RXN
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0034000
name: chondroitin-sulfate-ABC endolyase activity
namespace: molecular_function
def: "Catalysis of the endolytic cleavage of beta-1,4-galactosaminic bonds between N-acetylgalactosamine and either D-glucuronic acid or L-iduronic acid to produce a mixture of Delta4-unsaturated oligosaccharides of different sizes that are ultimately degraded to Delta4-unsaturated tetra- and disaccharides." [EC:4.2.2.20]
synonym: "chondroitin ABC eliminase activity" BROAD [EC:4.2.2.20]
synonym: "chondroitin sulfate ABC endoeliminase activity" EXACT [EC:4.2.2.20]
synonym: "chondroitin sulfate ABC endolyase activity" EXACT [EC:4.2.2.20]
synonym: "chondroitin sulfate ABC lyase activity" BROAD [EC:4.2.2.20]
synonym: "chondroitinase ABC activity" BROAD [EC:4.2.2.20]
synonym: "chondroitinase activity" BROAD [EC:4.2.2.20]
synonym: "ChS ABC lyase activity" BROAD [EC:4.2.2.20]
synonym: "ChS ABC lyase I activity" EXACT [EC:4.2.2.20]
xref: EC:4.2.2.20
xref: MetaCyc:4.2.2.20-RXN
is_a: GO:0047486 ! chondroitin ABC lyase activity

[Term]
id: GO:0034001
name: chondroitin-sulfate-ABC exolyase activity
namespace: molecular_function
def: "Catalysis of the exolytic cleavage of disaccharide residues from the non-reducing ends of both polymeric chondroitin sulfates and their oligosaccharide fragments." [EC:4.2.2.21]
synonym: "chondroitin ABC eliminase activity" BROAD [EC:4.2.2.21]
synonym: "chondroitin sulfate ABC exoeliminase activity" EXACT [EC:4.2.2.21]
synonym: "chondroitin sulfate ABC exolyase activity" EXACT [EC:4.2.2.21]
synonym: "chondroitin sulfate ABC lyase activity" BROAD [EC:4.2.2.21]
synonym: "chondroitinase ABC activity" BROAD [EC:4.2.2.21]
synonym: "chondroitinase activity" BROAD [EC:4.2.2.21]
synonym: "ChS ABC lyase activity" BROAD [EC:4.2.2.21]
synonym: "ChS ABC lyase II activity" EXACT [EC:4.2.2.21]
xref: EC:4.2.2.21
xref: MetaCyc:4.2.2.21-RXN
is_a: GO:0047486 ! chondroitin ABC lyase activity

[Term]
id: GO:0034002
name: (R)-limonene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranyl diphosphate = (4R)-limonene + diphosphate." [EC:4.2.3.20, RHEA:10943]
synonym: "(+)-limonene synthase activity" EXACT [EC:4.2.3.20]
synonym: "geranyl-diphosphate diphosphate-lyase [cyclizing, (+)-(4R)-limonene-forming] activity" EXACT [EC:4.2.3.20]
synonym: "geranyldiphosphate diphosphate lyase [(+)-(R)-limonene-forming] activity" EXACT [EC:4.2.3.20]
xref: EC:4.2.3.20
xref: KEGG:R06120
xref: MetaCyc:4.2.3.20-RXN
xref: RHEA:10943
is_a: GO:0010333 ! terpene synthase activity

[Term]
id: GO:0034003
name: vetispiradiene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + vetispiradiene." [EC:4.2.3.21, RHEA:10343]
synonym: "HVS" RELATED [EC:4.2.3.21]
synonym: "pemnaspirodiene synthase activity" EXACT [EC:4.2.3.21]
synonym: "trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, vetispiradiene-forming) activity" EXACT [EC:4.2.3.21]
synonym: "vetispiradiene cyclase activity" EXACT [EC:4.2.3.21]
synonym: "vetispiradiene-forming farnesyl pyrophosphate cyclase activity" EXACT [EC:4.2.3.21]
xref: EC:4.2.3.21
xref: KEGG:R06523
xref: MetaCyc:RXN-4823
xref: RHEA:10343
is_a: GO:0010334 ! sesquiterpene synthase activity

[Term]
id: GO:0034004
name: germacradienol synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + H2O = (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate." [EC:4.2.3.22]
synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase [(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol-forming] activity" EXACT [EC:4.2.3.22]
xref: EC:4.2.3.22
xref: KEGG:R07647
xref: MetaCyc:RXN-8648
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0034005
name: germacrene-A synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (+)-(R)-germacrene A + diphosphate." [EC:4.2.3.23, RHEA:12519]
synonym: "(+)-(10R)-germacrene A synthase activity" EXACT [EC:4.2.3.23]
synonym: "(+)-germacrene A synthase activity" EXACT [EC:4.2.3.23]
synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (germacrene-A-forming) activity" EXACT [EC:4.2.3.23]
synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase [(+)-germacrene-A-forming] activity" EXACT [EC:4.2.3.23]
synonym: "GAS" RELATED [EC:4.2.3.23]
synonym: "germacrene A synthase activity" EXACT [EC:4.2.3.23]
xref: EC:4.2.3.23
xref: KEGG:R07649
xref: MetaCyc:4.2.3.23-RXN
xref: RHEA:12519
is_a: GO:0010334 ! sesquiterpene synthase activity

[Term]
id: GO:0034006
name: amorpha-4,11-diene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = amorpha-4,11-diene + diphosphate." [EC:4.2.3.24, RHEA:18328]
synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (amorpha-4,11-diene-forming) activity" EXACT [EC:4.2.3.24]
synonym: "amorphadiene synthase activity" EXACT [EC:4.2.3.24]
xref: EC:4.2.3.24
xref: KEGG:R07630
xref: MetaCyc:4.2.3.24-RXN
xref: MetaCyc:RXN-8046
xref: RHEA:18328
is_a: GO:0010334 ! sesquiterpene synthase activity

[Term]
id: GO:0034007
name: S-linalool synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranyl diphosphate + H(2)O = (S)-linalool + diphosphate." [EC:4.2.3.25, RHEA:24119]
synonym: "3S-linalool synthase activity" EXACT [EC:4.2.3.25]
synonym: "geranyl-diphosphate diphosphate-lyase [(3S)-linalool-forming] activity" EXACT [EC:4.2.3.25]
synonym: "LIS" RELATED [EC:4.2.3.25]
xref: EC:4.2.3.25
xref: KEGG:R07631
xref: MetaCyc:4.2.3.25-RXN
xref: RHEA:24119
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0034008
name: R-linalool synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranyl diphosphate + H(2)O = (R)-linalool + diphosphate." [EC:4.2.3.26, RHEA:15812]
synonym: "(-)-3R-linalool synthase activity" EXACT [EC:4.2.3.26]
synonym: "(3R)-linalool synthase activity" EXACT [EC:4.2.3.26]
synonym: "geranyl-diphosphate diphosphate-lyase [(3R)-linalool-forming] activity" EXACT [EC:4.2.3.26]
xref: EC:4.2.3.26
xref: KEGG:R07632
xref: MetaCyc:4.2.3.26-RXN
xref: RHEA:15812
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0034009
name: isoprene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: dimethylallyl diphosphate = diphosphate + isoprene." [EC:4.2.3.27, RHEA:13372]
synonym: "dimethylallyl-diphosphate diphosphate-lyase (isoprene-forming) activity" EXACT [EC:4.2.3.27]
synonym: "ISPC" RELATED [EC:4.2.3.27]
synonym: "ISPS" RELATED [EC:4.2.3.27]
xref: EC:4.2.3.27
xref: KEGG:R08199
xref: MetaCyc:4.2.3.27-RXN
xref: RHEA:13372
is_a: GO:0010333 ! terpene synthase activity

[Term]
id: GO:0034010
name: sulfolactate sulfo-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-sulfolactate = pyruvate + sulfite." [EC:4.4.1.24, RHEA:21431]
synonym: "3-sulfolactate bisulfite-lyase (pyruvate-forming) activity" EXACT [EC:4.4.1.24]
synonym: "3-sulfolactate bisulfite-lyase activity" EXACT [EC:4.4.1.24]
synonym: "Suy" RELATED [EC:4.4.1.24]
synonym: "SuyAB" RELATED [EC:4.4.1.24]
xref: EC:4.4.1.24
xref: KEGG:R07633
xref: MetaCyc:4.4.1.24-RXN
xref: RHEA:21431
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0034011
name: L-cysteate sulfo-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-cysteate + H(2)O = NH(4)(+) + pyruvate + sulfite." [EC:4.4.1.25, RHEA:13444]
synonym: "CuyA" RELATED [EC:4.4.1.25]
synonym: "L-cysteate bisulfite-lyase (deaminating; pyruvate-forming) activity" EXACT [EC:4.4.1.25]
synonym: "L-cysteate sulfo-lyase (deaminating) activity" EXACT [EC:4.4.1.25]
xref: EC:4.4.1.25
xref: KEGG:R07634
xref: MetaCyc:4.4.1.25-RXN
xref: RHEA:13444
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0034012
name: FAD-AMP lyase (cyclizing) activity
namespace: molecular_function
def: "Catalysis of the reaction: FAD = AMP + riboflavin cyclic-4',5'-phosphate." [EC:4.6.1.15]
synonym: "FAD AMP-lyase (cyclic-FMN-forming) activity" EXACT [EC:4.6.1.15]
synonym: "FAD AMP-lyase (riboflavin-cyclic-4',5'-phosphate-forming) activity" EXACT [EC:4.6.1.15]
synonym: "FMN cyclase activity" EXACT [EC:4.6.1.15]
xref: EC:4.6.1.15
is_a: GO:0009975 ! cyclase activity
is_a: GO:0016849 ! phosphorus-oxygen lyase activity

[Term]
id: GO:0034013
name: aliphatic aldoxime dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: an aliphatic aldoxime = an aliphatic nitrile + H2O." [EC:4.99.1.5]
synonym: "aliphatic aldoxime hydro-lyase (aliphatic-nitrile-forming) activity" EXACT [EC:4.99.1.5]
synonym: "aliphatic aldoxime hydro-lyase activity" EXACT [EC:4.99.1.5]
synonym: "OxdA" RELATED [EC:4.99.1.5]
xref: EC:4.99.1.5
xref: MetaCyc:4.99.1.5-RXN
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0034014
name: response to triglyceride
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triglyceride stimulus." [GOC:sl]
synonym: "response to triacylglyceride" EXACT []
synonym: "response to triacylglycerol" EXACT []
is_a: GO:0033993 ! response to lipid
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0034015
name: L-ribulose-5-phosphate 3-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-ribulose 5-phosphate = L-xylulose 5-phosphate." [EC:5.1.3.22]
synonym: "L-xylulose 5-phosphate 3-epimerase activity" EXACT [EC:5.1.3.22]
synonym: "SgaU" RELATED [EC:5.1.3.22]
synonym: "UlaE" RELATED [EC:5.1.3.22]
xref: EC:5.1.3.22
xref: MetaCyc:LXULRU5P-RXN
xref: RHEA:18500
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0034016
name: polyenoic fatty acid isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: all-cis-icosa-5,8,11,14,17-pentaenoate = (5Z,7E,9E,14Z,17Z)-icosapentaenoate." [EC:5.3.3.13, RHEA:14892]
synonym: "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate delta8,11-delta7,8-isomerase activity" EXACT [EC:5.3.3.13]
synonym: "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate delta8,11-delta7,9-isomerase (trans-double-bond-forming) activity" EXACT [EC:5.3.3.13]
synonym: "(5Z,8Z,11Z,14Z,17Z)-icosapentaenoate delta8,11-delta7,9-isomerase (trans-double-bond-forming) activity" EXACT [EC:5.3.3.13]
synonym: "eicosapentaenoate cis-delta5,8,11,14,17-eicosapentaenoate cis-delta5-trans-delta7,9-cis-delta14,17 isomerase activity" EXACT [EC:5.3.3.13]
synonym: "PFI" RELATED [EC:5.3.3.13]
xref: EC:5.3.3.13
xref: KEGG:R06502
xref: MetaCyc:5.3.3.13-RXN
xref: RHEA:14892
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0034017
name: trans-2-decenoyl-acyl-carrier-protein isomerase activity
namespace: molecular_function
alt_id: GO:0043832
def: "Catalysis of the reaction: trans-dec-2-enoyl-[acyl-carrier protein] = cis-dec-3-enoyl-[acyl-carrier protein]." [EC:5.3.3.14, IMG:02508]
synonym: "beta-hydroxydecanoyl thioester dehydrase activity" BROAD [EC:5.3.3.14]
synonym: "decenoyl-acyl-carrier-protein delta2-trans-delta3-cis-isomerase activity" EXACT [EC:5.3.3.14]
synonym: "FabM" RELATED [EC:5.3.3.14]
synonym: "trans-2, cis-3 decenoyl-[acyl-carrier-protein] isomerase activity" EXACT []
synonym: "trans-2, cis-3 decenoyl-ACP isomerase activity" EXACT []
synonym: "trans-2,cis-3-decenoyl-ACP isomerase activity" EXACT [EC:5.3.3.14]
synonym: "trans-2-cis-3-decenoyl-ACP isomerase activity" EXACT [EC:5.3.3.14]
synonym: "trans-2-decenoyl-ACP isomerase activity" EXACT [EC:5.3.3.14]
xref: EC:5.3.3.14
xref: MetaCyc:5.3.3.14-RXN
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0034018
name: ascopyrone tautomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose = 1,5-anhydro-4-deoxy-D-glycero-hex-1-en-3-ulose." [EC:5.3.3.15]
synonym: "1,5-anhydro-D-glycero-hex-3-en-2-ulose delta3-delta1-isomerase activity" EXACT [EC:5.3.3.15]
synonym: "1,5-anhydro-D-glycero-hex-3-en-2-ulose tautomerase activity" EXACT [EC:5.3.3.15]
synonym: "APM tautomerase activity" EXACT [EC:5.3.3.15]
synonym: "APTM" RELATED [EC:5.3.3.15]
synonym: "ascopyrone intramolecular oxidoreductase activity" EXACT [EC:5.3.3.15]
synonym: "ascopyrone isomerase activity" EXACT [EC:5.3.3.15]
synonym: "ascopyrone P tautomerase activity" EXACT [EC:5.3.3.15]
xref: EC:5.3.3.15
xref: MetaCyc:5.3.3.15-RXN
xref: RHEA:22571
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0034019
name: obsolete capsanthin/capsorubin synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reactions: violaxanthin = capsorubin, and antheraxanthin = capsanthin." [EC:5.3.99.8]
comment: This term was made obsolete because it represents two reactions, and should be two separate terms.
synonym: "capsanthin-capsorubin synthase activity" EXACT [EC:5.3.99.8]
synonym: "capsanthin/capsorubin synthase activity" EXACT []
synonym: "CCS" RELATED [EC:5.3.99.8]
synonym: "ketoxanthophyll synthase activity" BROAD [EC:5.3.99.8]
synonym: "violaxanthin-capsorubin isomerase (ketone-forming) activity" NARROW [EC:5.3.99.8]
is_obsolete: true
consider: GO:0052727
consider: GO:0052728

[Term]
id: GO:0034020
name: neoxanthin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: all-trans-violaxanthin = all-trans-neoxanthin." [EC:5.3.99.9, RHEA:10131]
synonym: "NSY" RELATED [EC:5.3.99.9]
synonym: "violaxanthin-neoxanthin isomerase (epoxide-opening) activity" EXACT [EC:5.3.99.9]
xref: EC:5.3.99.9
xref: KEGG:R06948
xref: MetaCyc:RXN1F-155
xref: RHEA:10131
is_a: GO:0016860 ! intramolecular oxidoreductase activity

[Term]
id: GO:0034021
name: response to silicon dioxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a silicon dioxide stimulus." [GOC:sl]
synonym: "response to silica" EXACT []
synonym: "response to silox" EXACT []
is_a: GO:0010035 ! response to inorganic substance
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0034022
name: 3-(hydroxyamino)phenol mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxyaminophenol = aminohydroquinone." [EC:5.4.4.3, RHEA:20580]
synonym: "3-(hydroxyamino)phenol hydroxymutase activity" EXACT [EC:5.4.4.3]
synonym: "3-hydroxylaminophenol mutase activity" EXACT [EC:5.4.4.3]
synonym: "3HAP mutase activity" EXACT [EC:5.4.4.3]
xref: EC:5.4.4.3
xref: KEGG:R06988
xref: MetaCyc:5.4.4.3-RXN
xref: RHEA:20580
xref: UM-BBD_enzymeID:e0953
is_a: GO:0050486 ! intramolecular transferase activity, transferring hydroxy groups

[Term]
id: GO:0034023
name: 5-(carboxyamino)imidazole ribonucleotide mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate." [EC:5.4.99.18]
synonym: "5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole carboxymutase activity" EXACT [EC:5.4.99.18]
synonym: "class I PurE" RELATED [EC:5.4.99.18]
synonym: "N5-CAIR mutase activity" EXACT [EC:5.4.99.18]
synonym: "N5-carboxyaminoimidazole ribonucleotide mutase activity" EXACT [EC:5.4.99.18]
synonym: "PurE" RELATED [EC:5.4.99.18]
xref: EC:5.4.99.18
xref: MetaCyc:5.4.99.18-RXN
xref: RHEA:13196
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0034024
name: glutamate-putrescine ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamate + ATP + putrescine = gamma-L-glutamylputrescine + ADP + 2 H(+) + phosphate." [EC:6.3.1.11, RHEA:13636]
synonym: "gamma-glutamylputrescine synthetase activity" EXACT [EC:6.3.1.11]
synonym: "L-glutamate:putrescine ligase (ADP-forming) activity" EXACT [EC:6.3.1.11]
synonym: "YcjK" RELATED [EC:6.3.1.11]
xref: EC:6.3.1.11
xref: KEGG:R07414
xref: MetaCyc:RXN0-3901
xref: RHEA:13636
is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity

[Term]
id: GO:0034025
name: D-aspartate ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-aspartate + [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n = [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n + ADP + phosphate." [EC:6.3.1.12]
synonym: "aslfm" RELATED [EC:6.3.1.12]
synonym: "D-aspartate:[beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n ligase (ADP-forming) activity" EXACT [EC:6.3.1.12]
synonym: "D-aspartic acid-activating enzyme" RELATED [EC:6.3.1.12]
synonym: "UDP-MurNAc-pentapeptide:D-aspartate ligase activity" EXACT [EC:6.3.1.12]
xref: EC:6.3.1.12
xref: MetaCyc:6.3.1.12-RXN
is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity

[Term]
id: GO:0034026
name: L-amino-acid alpha-ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + an L-amino acid + an L-amino acid = ADP + phosphate + L-aminoacyl-L-amino acid." [EC:6.3.2.28]
synonym: "bacilysin synthetase activity" EXACT [EC:6.3.2.28]
synonym: "L-amino acid alpha-ligase activity" EXACT [EC:6.3.2.28]
synonym: "L-amino acid ligase activity" EXACT [EC:6.3.2.28]
synonym: "YwfE" RELATED [EC:6.3.2.28]
xref: EC:6.3.2.28
xref: MetaCyc:6.3.2.28-RXN
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0034027
name: (carboxyethyl)arginine beta-lactam-synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: N(2)-(2-carboxyethyl)-L-arginine + ATP = AMP + deoxyamidinoproclavaminate + diphosphate + 2 H(+)." [EC:6.3.3.4, RHEA:23623]
synonym: "beta-lactam synthetase activity" EXACT [EC:6.3.3.4]
synonym: "L-2-N-(2-carboxyethyl)arginine cyclo-ligase (AMP-forming) activity" EXACT [EC:6.3.3.4]
synonym: "L-N2-(2-carboxyethyl)arginine cyclo-ligase (AMP-forming) activity" EXACT [EC:6.3.3.4]
xref: EC:6.3.3.4
xref: KEGG:R05467
xref: MetaCyc:6.3.3.4-RXN
xref: RHEA:23623
is_a: GO:0016882 ! cyclo-ligase activity

[Term]
id: GO:0034028
name: 5-(carboxyamino)imidazole ribonucleotide synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole + ATP + bicarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 3 H(+) + phosphate." [EC:6.3.4.18, RHEA:19320]
synonym: "5-amino-1-(5-phospho-D-ribosyl)imidazole:carbon-dioxide ligase (ADP-forming) activity" EXACT [EC:6.3.4.18]
synonym: "N5-CAIR synthetase activity" EXACT [EC:6.3.4.18]
synonym: "N5-carboxyaminoimidazole ribonucleotide synthetase activity" EXACT [EC:6.3.4.18]
synonym: "PurK" RELATED [EC:6.3.4.18]
xref: EC:6.3.4.18
xref: KEGG:R07404
xref: MetaCyc:RXN0-742
xref: RHEA:19320
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0034029
name: 2-oxoglutarate carboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + ATP + bicarbonate = ADP + 2 H(+) + oxalosuccinate + phosphate." [EC:6.4.1.7, RHEA:20428]
synonym: "carboxylating factor for ICDH" RELATED [EC:6.4.1.7]
synonym: "CFI" RELATED [EC:6.4.1.7]
synonym: "OGC" RELATED [EC:6.4.1.7]
synonym: "oxalosuccinate synthetase activity" EXACT [EC:6.4.1.7]
xref: EC:6.4.1.7
xref: KEGG:R08201
xref: MetaCyc:RXN-8457
xref: RHEA:20428
is_a: GO:0016885 ! ligase activity, forming carbon-carbon bonds

[Term]
id: GO:0034030
name: ribonucleoside bisphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a ribonucleoside bisphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde]
subset: gosubset_prok
synonym: "ribonucleoside bisphosphate anabolism" EXACT []
synonym: "ribonucleoside bisphosphate biosynthesis" EXACT []
synonym: "ribonucleoside bisphosphate formation" EXACT []
synonym: "ribonucleoside bisphosphate synthesis" EXACT []
is_a: GO:0033866 ! nucleoside bisphosphate biosynthetic process
is_a: GO:0033875 ! ribonucleoside bisphosphate metabolic process

[Term]
id: GO:0034031
name: ribonucleoside bisphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a ribonucleoside bisphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde]
subset: gosubset_prok
synonym: "ribonucleoside bisphosphate breakdown" EXACT []
synonym: "ribonucleoside bisphosphate catabolism" EXACT []
synonym: "ribonucleoside bisphosphate degradation" EXACT []
is_a: GO:0033869 ! nucleoside bisphosphate catabolic process
is_a: GO:0033875 ! ribonucleoside bisphosphate metabolic process

[Term]
id: GO:0034032
name: purine nucleoside bisphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a purine nucleoside bisphosphate, a compound consisting of a purine base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde]
subset: gosubset_prok
synonym: "purine nucleoside bisphosphate metabolism" EXACT []
is_a: GO:0033865 ! nucleoside bisphosphate metabolic process
is_a: GO:0072521 ! purine-containing compound metabolic process

[Term]
id: GO:0034033
name: purine nucleoside bisphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a purine nucleoside bisphosphate, a compound consisting of a purine base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde]
subset: gosubset_prok
synonym: "purine nucleoside bisphosphate anabolism" EXACT []
synonym: "purine nucleoside bisphosphate biosynthesis" EXACT []
synonym: "purine nucleoside bisphosphate formation" EXACT []
synonym: "purine nucleoside bisphosphate synthesis" EXACT []
is_a: GO:0033866 ! nucleoside bisphosphate biosynthetic process
is_a: GO:0034032 ! purine nucleoside bisphosphate metabolic process
is_a: GO:0072522 ! purine-containing compound biosynthetic process

[Term]
id: GO:0034034
name: purine nucleoside bisphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a purine nucleoside bisphosphate, a compound consisting of a purine base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde]
subset: gosubset_prok
synonym: "purine nucleoside bisphosphate breakdown" EXACT []
synonym: "purine nucleoside bisphosphate catabolism" EXACT []
synonym: "purine nucleoside bisphosphate degradation" EXACT []
is_a: GO:0033869 ! nucleoside bisphosphate catabolic process
is_a: GO:0034032 ! purine nucleoside bisphosphate metabolic process
is_a: GO:0072523 ! purine-containing compound catabolic process

[Term]
id: GO:0034035
name: purine ribonucleoside bisphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a purine ribonucleoside bisphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde]
subset: gosubset_prok
synonym: "purine ribonucleoside bisphosphate metabolism" EXACT []
is_a: GO:0033875 ! ribonucleoside bisphosphate metabolic process
is_a: GO:0034032 ! purine nucleoside bisphosphate metabolic process

[Term]
id: GO:0034036
name: purine ribonucleoside bisphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a purine ribonucleoside bisphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde]
subset: gosubset_prok
synonym: "purine ribonucleoside bisphosphate anabolism" EXACT []
synonym: "purine ribonucleoside bisphosphate biosynthesis" EXACT []
synonym: "purine ribonucleoside bisphosphate formation" EXACT []
synonym: "purine ribonucleoside bisphosphate synthesis" EXACT []
is_a: GO:0034030 ! ribonucleoside bisphosphate biosynthetic process
is_a: GO:0034033 ! purine nucleoside bisphosphate biosynthetic process
is_a: GO:0034035 ! purine ribonucleoside bisphosphate metabolic process

[Term]
id: GO:0034037
name: purine ribonucleoside bisphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a purine ribonucleoside bisphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde]
subset: gosubset_prok
synonym: "purine ribonucleoside bisphosphate breakdown" EXACT []
synonym: "purine ribonucleoside bisphosphate catabolism" EXACT []
synonym: "purine ribonucleoside bisphosphate degradation" EXACT []
is_a: GO:0034031 ! ribonucleoside bisphosphate catabolic process
is_a: GO:0034034 ! purine nucleoside bisphosphate catabolic process
is_a: GO:0034035 ! purine ribonucleoside bisphosphate metabolic process

[Term]
id: GO:0034038
name: deoxyhypusine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine. Four sub-reactions have been identified,in which the intermediates remain tightly associated with the enzyme: spermidine + NAD+ = dehydrospermidine + NADH; dehydrospermidine + [enzyme]-lysine = N-(4-aminobutylidene)-[enzyme]-lysine + propane-1,3-diamine; N-(4-aminobutylidene)-[enzyme]-lysine + [eIF5A-precursor]-lysine = N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + [enzyme]-lysine; N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + NADH + H+ = [eIF5A-precursor]-deoxyhypusine + NAD+." [EC:2.5.1.46, GOC:pde, MetaCyc:2.5.1.46-RXN]
comment: Note that this term is equivalent to the obsolete molecular function term 'deoxyhypusine synthase activity ; GO:0004171' and corresponds closely to the biological process term 'deoxyhypusine biosynthetic process from spermidine, using deoxyhypusine synthase ; GO:0050983'.
synonym: "eIF-5A-deoxyhypusine synthase activity" EXACT [EC:2.5.1.46]
synonym: "eIF5A-precursor-lysine:spermidine 4-aminobutyltransferase (propane-1,3-diamine-forming) activity" EXACT [EC:2.5.1.46]
synonym: "spermidine:eIF5A-lysine 4-aminobutyltransferase (propane-1,3-diamine-forming) activity" EXACT [EC:2.5.1.46]
xref: EC:2.5.1.46
xref: MetaCyc:2.5.1.46-RXN
xref: Reactome:REACT_100262 "EIF5A(Dhp) + 1,3-diaminopropane <=> EIF5A + spermidine, Canis familiaris"
xref: Reactome:REACT_100329 "EIF5A + spermidine <=> EIF5A(Dhp) + 1,3-diaminopropane, Canis familiaris"
xref: Reactome:REACT_101738 "EIF5A + spermidine <=> EIF5A(Dhp) + 1,3-diaminopropane, Oryza sativa"
xref: Reactome:REACT_102888 "EIF5A + spermidine <=> EIF5A(Dhp) + 1,3-diaminopropane, Schizosaccharomyces pombe"
xref: Reactome:REACT_104173 "EIF5A + spermidine <=> EIF5A(Dhp) + 1,3-diaminopropane, Danio rerio"
xref: Reactome:REACT_107932 "EIF5A(Dhp) + 1,3-diaminopropane <=> EIF5A + spermidine, Sus scrofa"
xref: Reactome:REACT_108065 "EIF5A + spermidine <=> EIF5A(Dhp) + 1,3-diaminopropane, Xenopus tropicalis"
xref: Reactome:REACT_110683 "EIF5A(Dhp) + 1,3-diaminopropane <=> EIF5A + spermidine, Taeniopygia guttata"
xref: Reactome:REACT_110942 "EIF5A(Dhp) + 1,3-diaminopropane <=> EIF5A + spermidine, Arabidopsis thaliana"
xref: Reactome:REACT_113251 "EIF5A(Dhp) + 1,3-diaminopropane <=> EIF5A + spermidine, Caenorhabditis elegans"
xref: Reactome:REACT_115046 "EIF5A + spermidine <=> EIF5A(Dhp) + 1,3-diaminopropane, Caenorhabditis elegans"
xref: Reactome:REACT_12481 "EIF5A(Dhp) + 1,3-diaminopropane <=> EIF5A + spermidine, Homo sapiens"
xref: Reactome:REACT_12551 "EIF5A + spermidine <=> EIF5A(Dhp) + 1,3-diaminopropane, Homo sapiens"
xref: Reactome:REACT_29295 "EIF5A(Dhp) + 1,3-diaminopropane <=> EIF5A + spermidine, Schizosaccharomyces pombe"
xref: Reactome:REACT_34429 "EIF5A + spermidine <=> EIF5A(Dhp) + 1,3-diaminopropane, Dictyostelium discoideum"
xref: Reactome:REACT_67840 "EIF5A + spermidine <=> EIF5A(Dhp) + 1,3-diaminopropane, Saccharomyces cerevisiae"
xref: Reactome:REACT_76973 "EIF5A + spermidine <=> EIF5A(Dhp) + 1,3-diaminopropane, Drosophila melanogaster"
xref: Reactome:REACT_79026 "EIF5A(Dhp) + 1,3-diaminopropane <=> EIF5A + spermidine, Rattus norvegicus"
xref: Reactome:REACT_80696 "EIF5A + spermidine <=> EIF5A(Dhp) + 1,3-diaminopropane, Mus musculus"
xref: Reactome:REACT_83693 "EIF5A + spermidine <=> EIF5A(Dhp) + 1,3-diaminopropane, Taeniopygia guttata"
xref: Reactome:REACT_83803 "EIF5A(Dhp) + 1,3-diaminopropane <=> EIF5A + spermidine, Saccharomyces cerevisiae"
xref: Reactome:REACT_84819 "EIF5A(Dhp) + 1,3-diaminopropane <=> EIF5A + spermidine, Mus musculus"
xref: Reactome:REACT_85742 "EIF5A(Dhp) + 1,3-diaminopropane <=> EIF5A + spermidine, Oryza sativa"
xref: Reactome:REACT_91359 "EIF5A + spermidine <=> EIF5A(Dhp) + 1,3-diaminopropane, Arabidopsis thaliana"
xref: Reactome:REACT_91583 "EIF5A(Dhp) + 1,3-diaminopropane <=> EIF5A + spermidine, Xenopus tropicalis"
xref: Reactome:REACT_92650 "EIF5A + spermidine <=> EIF5A(Dhp) + 1,3-diaminopropane, Rattus norvegicus"
xref: Reactome:REACT_93182 "EIF5A(Dhp) + 1,3-diaminopropane <=> EIF5A + spermidine, Bos taurus"
xref: Reactome:REACT_94750 "EIF5A(Dhp) + 1,3-diaminopropane <=> EIF5A + spermidine, Danio rerio"
xref: Reactome:REACT_94970 "EIF5A + spermidine <=> EIF5A(Dhp) + 1,3-diaminopropane, Bos taurus"
xref: Reactome:REACT_95014 "EIF5A + spermidine <=> EIF5A(Dhp) + 1,3-diaminopropane, Sus scrofa"
xref: Reactome:REACT_95120 "EIF5A(Dhp) + 1,3-diaminopropane <=> EIF5A + spermidine, Drosophila melanogaster"
xref: Reactome:REACT_99111 "EIF5A(Dhp) + 1,3-diaminopropane <=> EIF5A + spermidine, Dictyostelium discoideum"
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0034039
name: 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
namespace: molecular_function
def: "Catalysis of the removal of 8-oxo-7,8-dihydroguanine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar." [GOC:mah, PMID:17641464]
synonym: "8-oxoG DNA N-glycosylase activity" EXACT []
is_a: GO:0008534 ! oxidized purine nucleobase lesion DNA N-glycosylase activity

[Term]
id: GO:0034040
name: lipid-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + lipid(in) = ADP + phosphate + lipid(out)." [GOC:BHF, GOC:rl]
is_a: GO:0005319 ! lipid transporter activity
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances

[Term]
id: GO:0034041
name: sterol-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + sterol(in) = ADP + phosphate + sterol(out)." [GOC:BHF, GOC:rl]
is_a: GO:0015248 ! sterol transporter activity
is_a: GO:0015665 ! alcohol transmembrane transporter activity
is_a: GO:0034040 ! lipid-transporting ATPase activity

[Term]
id: GO:0034042
name: 5-formyluracil DNA N-glycosylase activity
namespace: molecular_function
def: "Catalysis of the removal of 5-formyluracil bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar." [GOC:mah, PMID:17641464]
synonym: "5-foU DNA N-glycosylase activity" EXACT []
is_a: GO:0000703 ! oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity

[Term]
id: GO:0034043
name: 5-hydroxymethyluracil DNA N-glycosylase activity
namespace: molecular_function
def: "Catalysis of the removal of 5-hydroxymethyluracil bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar." [GOC:mah, PMID:17641464]
synonym: "5-hmU DNA N-glycosylase activity" EXACT []
is_a: GO:0000703 ! oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity

[Term]
id: GO:0034044
name: exomer complex
namespace: cellular_component
def: "A protein complex that forms a coat structure on vesicles involved in exocytosis of proteins from the trans-Golgi network to the cell surface; in Saccharomyces, the complex contains Chs5p, Chs6p, and Chs6p paralogues." [PMID:16498409, PMID:17000877]
is_a: GO:0043234 ! protein complex
is_a: GO:0044431 ! Golgi apparatus part
is_a: GO:0044433 ! cytoplasmic vesicle part
relationship: part_of GO:0030140 ! trans-Golgi network transport vesicle

[Term]
id: GO:0034045
name: pre-autophagosomal structure membrane
namespace: cellular_component
def: "A cellular membrane associated with the pre-autophagosomal structure." [GOC:mah, GOC:rph, PMID:16874040, PMID:17382324]
synonym: "isolation membrane" RELATED []
synonym: "PAS membrane" EXACT []
synonym: "phagophore" RELATED [PMID:20811355]
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0098588 ! bounding membrane of organelle
is_a: GO:0098805 ! whole membrane
relationship: part_of GO:0000407 ! pre-autophagosomal structure

[Term]
id: GO:0034046
name: poly(G) binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of guanine residues in an RNA molecule." [GOC:mah]
synonym: "poly(G) binding, within an RNA molecule" EXACT []
synonym: "poly(rG) binding" EXACT [GOC:mah]
is_a: GO:0070717 ! poly-purine tract binding

[Term]
id: GO:0034047
name: regulation of protein phosphatase type 2A activity
namespace: biological_process
def: "Any process that modulates the activity of the enzyme protein phosphatase type 2A." [GOC:mah]
synonym: "regulation of protein phosphatase type 2 activity" RELATED [GOC:dph, GOC:rl]
is_a: GO:0043666 ! regulation of phosphoprotein phosphatase activity

[Term]
id: GO:0034048
name: negative regulation of protein phosphatase type 2A activity
namespace: biological_process
def: "Any process that stops or reduces the activity of the enzyme protein phosphatase type 2A." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation of protein phosphatase 2 activity" RELATED [GOC:dph, GOC:rl]
synonym: "down regulation of protein phosphatase type 2A activity" EXACT []
synonym: "down-regulation of protein phosphatase type 2A activity" EXACT []
synonym: "downregulation of protein phosphatase 2 activity" RELATED [GOC:dph, GOC:rl]
synonym: "downregulation of protein phosphatase type 2A activity" EXACT []
synonym: "inhibition of protein phosphatase 2 activity" RELATED [GOC:dph, GOC:rl]
synonym: "inhibition of protein phosphatase type 2A activity" NARROW []
synonym: "negative regulation of protein phosphatase 2 activity" RELATED [GOC:dph, GOC:rl]
is_a: GO:0032515 ! negative regulation of phosphoprotein phosphatase activity
is_a: GO:0034047 ! regulation of protein phosphatase type 2A activity

[Term]
id: GO:0034049
name: positive regulation of protein phosphatase type 2A activity
namespace: biological_process
def: "Any process that activates or increases the activity of the enzyme protein phosphatase type 2A." [GOC:mah]
subset: gosubset_prok
synonym: "activation of protein phosphatase type 2A activity" NARROW []
synonym: "positive regulation of protein phosphatase 2 activity" RELATED [GOC:dph, GOC:rl]
synonym: "stimulation of protein phosphatase 2 activity" RELATED [GOC:dph, GOC:rl]
synonym: "stimulation of protein phosphatase type 2A activity" NARROW []
synonym: "up regulation of protein phosphatase 2 activity" RELATED [GOC:dph, GOC:rl]
synonym: "up regulation of protein phosphatase type 2A activity" EXACT []
synonym: "up-regulation of protein phosphatase 2 activity" RELATED [GOC:dph, GOC:rl]
synonym: "up-regulation of protein phosphatase type 2A activity" EXACT []
synonym: "upregulation of protein phosphatase 2 activity" RELATED [GOC:dph, GOC:rl]
synonym: "upregulation of protein phosphatase type 2A activity" EXACT []
is_a: GO:0032516 ! positive regulation of phosphoprotein phosphatase activity
is_a: GO:0034047 ! regulation of protein phosphatase type 2A activity

[Term]
id: GO:0034050
name: host programmed cell death induced by symbiont
namespace: biological_process
def: "Cell death in a host resulting from activation of host endogenous cellular processes after direct or indirect interaction with a symbiont (defined as the smaller of two, or more, organisms engaged in symbiosis, a close interaction encompassing mutualism through parasitism). An example of direct interaction is contact with penetrating hyphae of a fungus; an example of indirect interaction is encountering symbiont-secreted molecules." [GOC:pamgo_curators]
comment: Note that this term is to be used to annotate gene products in the host, not the symbiont. To annotate gene products in the symbiont that induce programmed cell death in the host, consider the biological process term 'induction by symbiont of host programmed cell death ; GO:0052044'.
is_a: GO:0012501 ! programmed cell death

[Term]
id: GO:0034051
name: negative regulation of plant-type hypersensitive response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the hypersensitive response in a plant." [GOC:pamgo_curators]
synonym: "down regulation of plant-type hypersensitive response" EXACT [GOC:pamgo_curators]
synonym: "down-regulation of plant-type hypersensitive response" EXACT [GOC:pamgo_curators]
synonym: "downregulation of plant-type hypersensitive response" EXACT [GOC:pamgo_curators]
synonym: "inhibition of plant-type hypersensitive response" NARROW [GOC:pamgo_curators]
synonym: "negative regulation of HR" EXACT [GOC:pamgo_curators]
synonym: "negative regulation of HR-PCD" EXACT [GOC:pamgo_curators]
synonym: "negative regulation of plant hypersensitive response" EXACT [GOC:pamgo_curators]
is_a: GO:0010363 ! regulation of plant-type hypersensitive response
is_a: GO:0043069 ! negative regulation of programmed cell death
is_a: GO:0045824 ! negative regulation of innate immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009626 ! plant-type hypersensitive response
relationship: negatively_regulates GO:0009626 ! plant-type hypersensitive response

[Term]
id: GO:0034052
name: positive regulation of plant-type hypersensitive response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the hypersensitive response in a plant." [GOC:pamgo_curators]
synonym: "activation of plant-type hypersensitive response" NARROW [GOC:pamgo_curators]
synonym: "positive regulation of HR" EXACT [GOC:pamgo_curators]
synonym: "positive regulation of HR-PCD" RELATED [GOC:pamgo_curators]
synonym: "positive regulation of plant hypersensitive response" EXACT [GOC:pamgo_curators]
synonym: "stimulation of plant-type hypersensitive response" NARROW [GOC:pamgo_curators]
synonym: "up regulation of plant-type hypersensitive response" EXACT [GOC:pamgo_curators]
synonym: "up-regulation of plant-type hypersensitive response" EXACT [GOC:pamgo_curators]
synonym: "upregulation of plant-type hypersensitive response" EXACT [GOC:pamgo_curators]
is_a: GO:0010363 ! regulation of plant-type hypersensitive response
is_a: GO:0043068 ! positive regulation of programmed cell death
is_a: GO:0045089 ! positive regulation of innate immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009626 ! plant-type hypersensitive response
relationship: positively_regulates GO:0009626 ! plant-type hypersensitive response

[Term]
id: GO:0034053
name: modulation by symbiont of host defense-related programmed cell death
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of defense-related programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term 'plant-type hypersensitive response ; GO:0009626'.
synonym: "modulation by symbiont of host defense-related PCD" EXACT [GOC:pamgo_curators]
synonym: "modulation by symbiont of host HR" NARROW [GOC:pamgo_curators]
synonym: "modulation by symbiont of host hypersensitive response" NARROW [GOC:pamgo_curators]
synonym: "modulation by symbiont of plant HR" NARROW [GOC:pamgo_curators]
synonym: "modulation by symbiont of plant hypersensitive response" NARROW [GOC:pamgo_curators]
is_a: GO:0052031 ! modulation by symbiont of host defense response
is_a: GO:0052040 ! modulation by symbiont of host programmed cell death

[Term]
id: GO:0034054
name: negative regulation by symbiont of host defense-related programmed cell death
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of defense-related programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term 'negative regulation of plant-type hypersensitive response ; GO:0034051'.
synonym: "down regulation by symbiont of host defense-related programmed cell death" EXACT [GOC:pamgo_curators]
synonym: "down-regulation by symbiont of host defense-related programmed cell death" EXACT [GOC:pamgo_curators]
synonym: "downregulation by symbiont of host defense-related programmed cell death" EXACT [GOC:pamgo_curators]
synonym: "inhibition by symbiont of host defense-related PCD" NARROW [GOC:pamgo_curators]
synonym: "inhibition by symbiont of host defense-related programmed cell death" NARROW [GOC:pamgo_curators]
synonym: "inhibition of host defense-related PCD" NARROW [GOC:pamgo_curators]
synonym: "inhibition of HR" NARROW [GOC:pamgo_curators]
synonym: "inhibition of hypersensitive response" NARROW [GOC:pamgo_curators]
synonym: "negative regulation by symbiont of host defense-related PCD" EXACT [GOC:pamgo_curators]
synonym: "negative regulation by symbiont of plant HR" NARROW [GOC:pamgo_curators]
synonym: "negative regulation by symbiont of plant hypersensitive response" NARROW [GOC:pamgo_curators]
synonym: "suppression by symbiont of host defense-related programmed cell death" NARROW [GOC:pamgo_curators]
synonym: "suppression of HR" NARROW [GOC:pamgo_curators]
is_a: GO:0034053 ! modulation by symbiont of host defense-related programmed cell death
is_a: GO:0052037 ! negative regulation by symbiont of host defense response
is_a: GO:0052041 ! negative regulation by symbiont of host programmed cell death

[Term]
id: GO:0034055
name: positive regulation by symbiont of host defense-related programmed cell death
namespace: biological_process
def: "Any process in which an organism activates or increases the frequency, rate or extent of defense-related programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term 'positive regulation of plant-type hypersensitive response ; GO:0034052'.
synonym: "activation by symbiont of host defense-related programmed cell death" NARROW [GOC:pamgo_curators]
synonym: "activation of HR" NARROW [GOC:pamgo_curators]
synonym: "activation of hypersensitive response" NARROW [GOC:pamgo_curators]
synonym: "enhancement by symbiont of host defense-related PCDprogrammed cell death" NARROW [GOC:pamgo_curators]
synonym: "positive regulation by symbiont of host defense-related PCD" EXACT [GOC:pamgo_curators]
synonym: "positive regulation by symbiont of plant HR" NARROW [GOC:pamgo_curators]
synonym: "positive regulation by symbiont of plant hypersensitive response" NARROW [GOC:pamgo_curators]
synonym: "stimulation by symbiont of host defense-related programmed cell death" NARROW [GOC:pamgo_curators]
synonym: "up regulation by symbiont of host defense-related programmed cell death" EXACT [GOC:pamgo_curators]
synonym: "up-regulation by symbiont of host defense-related programmed cell death" EXACT [GOC:pamgo_curators]
synonym: "upregulation by symbiont of host defense-related programmed cell death" EXACT [GOC:pamgo_curators]
is_a: GO:0034053 ! modulation by symbiont of host defense-related programmed cell death
is_a: GO:0052042 ! positive regulation by symbiont of host programmed cell death
is_a: GO:0052509 ! positive regulation by symbiont of host defense response

[Term]
id: GO:0034056
name: estrogen response element binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the estrogen response element (ERE), a conserved sequence found in the promoters of genes whose expression is regulated in response to estrogen." [GOC:ecd, PMID:15036253, PMID:17975005]
comment: Note that as agreed during the transcription overhaul, terms specifying binding to specific transcription regulatory motifs are no longer being created. The level of specificity GO has decided to go to is the "core promoter", "core promoter proximal region" and "enhancer". To capture more detail, please consider using column 16.
synonym: "ERE binding" EXACT []
is_a: GO:0044212 ! transcription regulatory region DNA binding

[Term]
id: GO:0034057
name: RNA strand-exchange activity
namespace: molecular_function
def: "Facilitates the displacement of one strand of an RNA-RNA duplex and its replacement with a different strand of higher complementarity." [GOC:mcc, PMID:9769100]
is_a: GO:0003725 ! double-stranded RNA binding
is_a: GO:0003727 ! single-stranded RNA binding

[Term]
id: GO:0034058
name: endosomal vesicle fusion
namespace: biological_process
def: "The homotypic fusion of endocytic vesicles to form or add to an early endosome." [PMID:11964142, PMID:9422733]
synonym: "endosome vesicle fusion" EXACT []
is_a: GO:0006906 ! vesicle fusion

[Term]
id: GO:0034059
name: response to anoxia
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating a decline in oxygen levels to trace amounts, <0.1%." [GOC:kmv]
comment: Note that this term should not be confused with 'response to hypoxia ; GO:0001666'.
synonym: "response to anoxic stress" EXACT []
is_a: GO:0006950 ! response to stress
is_a: GO:0036293 ! response to decreased oxygen levels

[Term]
id: GO:0034060
name: cyanelle stroma
namespace: cellular_component
def: "The space enclosed by the double membrane of a cyanelle." [GOC:rph]
is_a: GO:0009532 ! plastid stroma
relationship: part_of GO:0009842 ! cyanelle

[Term]
id: GO:0034061
name: DNA polymerase activity
namespace: molecular_function
def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a nucleic acid template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:mah]
subset: goslim_metagenomics
subset: gosubset_prok
synonym: "deoxynucleate polymerase activity" EXACT [EC:2.7.7.7]
synonym: "deoxyribonucleate nucleotidyltransferase activity" EXACT [EC:2.7.7.7]
synonym: "deoxyribonucleic acid polymerase activity" EXACT [EC:2.7.7.7]
synonym: "deoxyribonucleic polymerase activity" EXACT [EC:2.7.7.7]
synonym: "DNA nucleotidyltransferase activity" EXACT [EC:2.7.7.7]
xref: Reactome:REACT_115680 "Insertion of correct bases opposite to the lesion by Pol kappa, Gallus gallus"
xref: Reactome:REACT_115778 "Elongation by Pol zeta complex, Gallus gallus"
xref: Reactome:REACT_115899 "Elongation by Pol kappa, Gallus gallus"
xref: Reactome:REACT_115932 "Insertion of correct bases opposite to the lesion by Pol eta, Gallus gallus"
xref: Reactome:REACT_116106 "Repair of ~27-30 bp long patch by DNA Pol Epsilon, Gallus gallus"
xref: Reactome:REACT_116167 "Elongation by Pol eta, Gallus gallus"
is_a: GO:0016779 ! nucleotidyltransferase activity
relationship: part_of GO:0071897 ! DNA biosynthetic process

[Term]
id: GO:0034062
name: RNA polymerase activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template." [EC:2.7.7.6, GOC:mah]
subset: goslim_metagenomics
subset: gosubset_prok
synonym: "C ribonucleic acid formation factors" RELATED [EC:2.7.7.6]
synonym: "C RNA formation factors" RELATED [EC:2.7.7.6]
synonym: "ribonucleate nucleotidyltransferase activity" EXACT [EC:2.7.7.6]
synonym: "ribonucleate polymerase activity" EXACT [EC:2.7.7.6]
synonym: "ribonucleic acid nucleotidyltransferase" BROAD [EC:2.7.7.6]
synonym: "ribonucleic acid polymerase activity" EXACT [EC:2.7.7.6]
synonym: "ribonucleic acid transcriptase activity" EXACT [EC:2.7.7.6]
synonym: "ribonucleic polymerase activity" EXACT [EC:2.7.7.6]
synonym: "ribonucleic transcriptase activity" EXACT [EC:2.7.7.6]
synonym: "RNA nucleotidyltransferase activity" EXACT [EC:2.7.7.6]
synonym: "RNA transcriptase activity" EXACT [EC:2.7.7.6]
synonym: "transcriptase" BROAD [EC:2.7.7.6]
is_a: GO:0016779 ! nucleotidyltransferase activity

[Term]
id: GO:0034063
name: stress granule assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule." [GOC:mah, PMID:17392519]
synonym: "SG assembly" EXACT [PMID:19825938]
is_a: GO:0022618 ! ribonucleoprotein complex assembly
is_a: GO:0070925 ! organelle assembly

[Term]
id: GO:0034064
name: Tor2-Mei2-Ste11 complex
namespace: cellular_component
def: "A protein complex that contains the transcription factor Ste11 and the RNA binding protein Mei2; involved in regulation of conjugation in fission yeast." [GOC:vw, PMID:17046992]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0034065
name: replication fork processing at rDNA locus
namespace: biological_process
def: "The process in which a DNA replication fork that has stalled at the rDNA replication fork barrier (RFB) is repaired and replication is restarted." [GOC:vw]
synonym: "recovery from replication fork arrest at rDNA locus" EXACT []
synonym: "recovery from replication fork stalling at rDNA locus" EXACT []
synonym: "replication fork processing at ribosomal DNA locus" EXACT []
is_a: GO:0031297 ! replication fork processing
is_a: GO:0043007 ! maintenance of rDNA

[Term]
id: GO:0034066
name: RIC1-RGP1 guanyl-nucleotide exchange factor complex
namespace: cellular_component
def: "A protein complex that acts as a nucleotide exchange factor for the GTPase Ypt6p, and is required for fusion of endosome-derived vesicles with the Golgi." [GOC:jh, GOC:mah, PMID:10990452]
synonym: "Ric1p-Rgp1p complex" RELATED []
xref: IntAct:EBI-9517136
is_a: GO:0032045 ! guanyl-nucleotide exchange factor complex
is_a: GO:0044431 ! Golgi apparatus part

[Term]
id: GO:0034067
name: protein localization to Golgi apparatus
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus." [GOC:mah]
synonym: "protein localisation in Golgi apparatus" EXACT [GOC:mah]
synonym: "protein localization in Golgi apparatus" EXACT [GOC:curators]
is_a: GO:0033365 ! protein localization to organelle

[Term]
id: GO:0034068
name: aminoglycoside nucleotidyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside triphosphate + aminoglycoside = diphosphate + nucleotidylaminoglycoside." [GOC:cb]
subset: gosubset_prok
synonym: "aminoglycoside adenylyltransferase activity" NARROW []
synonym: "streptomycin adenylate synthetase activity" NARROW [EC:2.7.7.47]
synonym: "streptomycin adenyltransferase activity" NARROW [EC:2.7.7.47]
synonym: "streptomycin adenylylase activity" NARROW [EC:2.7.7.47]
synonym: "streptomycin adenylyltransferase activity" NARROW [EC:2.7.7.47]
synonym: "streptomycin-spectinomycin adenylyltransferase activity" NARROW [EC:2.7.7.47]
is_a: GO:0016779 ! nucleotidyltransferase activity

[Term]
id: GO:0034069
name: aminoglycoside N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + N-acetylaminoglycoside." [GOC:cb]
subset: gosubset_prok
synonym: "kanamycin acetyltransferase activity" NARROW []
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0034070
name: aminoglycoside 1-N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + 1-N-acetylaminoglycoside. This is acetylation of the 1-amino group of the central deoxystreptamine ring." [GOC:cb]
is_a: GO:0034069 ! aminoglycoside N-acetyltransferase activity

[Term]
id: GO:0034071
name: aminoglycoside phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + aminoglycoside = ADP + phosphoaminoglycoside." [GOC:cb, GOC:mah]
subset: gosubset_prok
synonym: "aminoglycoside kinase activity" EXACT []
xref: EC:2.7.1.-
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0034072
name: squalene cyclase activity
namespace: molecular_function
def: "Catalysis of the reaction: squalene = triterpene." [GOC:cb, PMID:18033581]
is_a: GO:0009975 ! cyclase activity

[Term]
id: GO:0034073
name: tetrahymanol cyclase activity
namespace: molecular_function
def: "Catalysis of the reaction: squalene = tetrahymanol." [CHEBI:9493, GOC:cb, PMID:18033581]
is_a: GO:0034072 ! squalene cyclase activity

[Term]
id: GO:0034074
name: marneral synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: oxidosqualene = marneral." [GOC:cb, http://www.wiley-vch.de/contents/jc_2002/2006/z503420_s.pdf, PMID:16425307, PMID:18033581]
xref: MetaCyc:RXN-9664
is_a: GO:0031559 ! oxidosqualene cyclase activity

[Term]
id: GO:0034075
name: arabidiol synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: oxidosqualene + H2O = arabidiol ((13R,14R,17E)-malabarica-17,21-diene-3beta,14-diol)." [GOC:cb, PMID:16774269, PMID:17474751]
is_a: GO:0031559 ! oxidosqualene cyclase activity

[Term]
id: GO:0034076
name: cucurbitadienol synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: oxidosqualene = cucurbitadienol." [GOC:cb, PMID:18033581]
is_a: GO:0031559 ! oxidosqualene cyclase activity

[Term]
id: GO:0034077
name: butanediol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving butanediol; the biologically relevant isomer is 2,3-butanediol, CH3CH(OH)CH(OH)CH3." [ISBN:0911910123, MetaCyc:BUTANEDIOL, MetaCyc:P125-PWY]
subset: gosubset_prok
synonym: "butanediol metabolism" EXACT []
synonym: "butylene glycol metabolic process" EXACT []
synonym: "butylene glycol metabolism" EXACT []
is_a: GO:0042844 ! glycol metabolic process
is_a: GO:1902652 ! secondary alcohol metabolic process

[Term]
id: GO:0034078
name: butanediol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of butanediol; the biologically relevant isomer is 2,3-butanediol, CH3CH(OH)CH(OH)CH3." [GOC:mah, ISBN:0911910123, MetaCyc:125-PWY, MetaCyc:BUTANEDIOL]
subset: gosubset_prok
synonym: "butanediol breakdown" EXACT []
synonym: "butanediol catabolism" EXACT []
synonym: "butanediol degradation" EXACT []
synonym: "butanediol utilization" RELATED []
synonym: "butylene glycol catabolic process" EXACT []
synonym: "butylene glycol catabolism" EXACT []
is_a: GO:0034077 ! butanediol metabolic process
is_a: GO:0042846 ! glycol catabolic process

[Term]
id: GO:0034079
name: butanediol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of butanediol; the biologically relevant isomer is 2,3-butanediol, CH3CH(OH)CH(OH)CH3." [GOC:mah, ISBN:0911910123, MetaCyc:125-PWY, MetaCyc:BUTANEDIOL]
subset: gosubset_prok
synonym: "butanediol anabolism" EXACT []
synonym: "butanediol biosynthesis" EXACT []
synonym: "butanediol formation" EXACT []
synonym: "butanediol synthesis" EXACT []
synonym: "butylene glycol biosynthesis" EXACT []
synonym: "butylene glycol biosynthetic process" EXACT []
xref: MetaCyc:P125-PWY
is_a: GO:0034077 ! butanediol metabolic process
is_a: GO:0042845 ! glycol biosynthetic process
is_a: GO:1902653 ! secondary alcohol biosynthetic process

[Term]
id: GO:0034080
name: CENP-A containing nucleosome assembly
namespace: biological_process
alt_id: GO:0034509
def: "The formation of nucleosomes containing the histone H3 variant CENP-A to form centromeric chromatin. This specialised chromatin occurs at centromeric region in point centromeres,  and the central core in modular centromeres." [GOC:mah, GOC:vw, PMID:18158900, PMID:19217403]
synonym: "CenH3-containing nucleosome assembly at centromere" RELATED []
synonym: "CENP-A containing nucleosome assembly at centromere" EXACT [GOC:vw]
synonym: "CENP-A deposition" RELATED [GOC:vw]
synonym: "CENP-A loading" RELATED [GOC:vw]
synonym: "centromere specific nucleosome exchange" RELATED [GOC:mah]
synonym: "centromere-specific histone exchange" EXACT [GOC:mah, GOC:vw]
synonym: "centromeric DNA replication-independent nucleosome assembly" EXACT [GOC:mah]
synonym: "DNA replication-independent nucleosome assembly at centromere" EXACT [GOC:mah]
xref: Reactome:REACT_22186 "Deposition of New CENPA-containing Nucleosomes at the Centromere, Homo sapiens"
is_a: GO:0006336 ! DNA replication-independent nucleosome assembly
is_a: GO:0031055 ! chromatin remodeling at centromere
is_a: GO:0043486 ! histone exchange
relationship: has_part GO:0061644 ! protein localization to CENP-A containing chromatin
relationship: part_of GO:0034508 ! centromere complex assembly
relationship: part_of GO:0061641 ! CENP-A containing chromatin organization

[Term]
id: GO:0034081
name: polyketide synthase complex
namespace: cellular_component
def: "A protein complex that carries out enzymatic reactions involved in the biosynthesis of polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones." [GOC:mah, PMID:12636085]
synonym: "PKS" RELATED []
synonym: "PKS complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0034082
name: type II polyketide synthase complex
namespace: cellular_component
def: "A polyketide synthase complex that consists of several different polypeptide chains, each of which catalyzes a single reaction." [GOC:cb, GOC:mah, PMID:12636085]
synonym: "type II PKS" EXACT []
synonym: "type II PKS complex" EXACT []
synonym: "type II polyketide synthase" EXACT []
is_a: GO:0034081 ! polyketide synthase complex

[Term]
id: GO:0034083
name: type III polyketide synthase complex
namespace: cellular_component
def: "A polyketide synthase complex that consists of two identical ketosynthase polypeptides." [GOC:cb, PMID:12636085]
synonym: "type III PKS" EXACT []
synonym: "type III PKS complex" EXACT []
synonym: "type III polyketide synthase" EXACT []
is_a: GO:0034081 ! polyketide synthase complex

[Term]
id: GO:0034084
name: steryl deacetylase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of an acetyl group or groups from an acetylated sterol." [GOC:rb, PMID:18034159]
synonym: "sterol deacetylase activity" EXACT []
is_a: GO:0019213 ! deacetylase activity

[Term]
id: GO:0034085
name: establishment of sister chromatid cohesion
namespace: biological_process
def: "The process in which the sister chromatids of a replicated chromosome become associated with each other during S phase." [GOC:jh, GOC:mah, PMID:14623866]
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0007062 ! sister chromatid cohesion

[Term]
id: GO:0034086
name: maintenance of sister chromatid cohesion
namespace: biological_process
def: "The process in which the association between sister chromatids of a replicated chromosome is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate." [GOC:mah, PMID:14623866]
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0007062 ! sister chromatid cohesion

[Term]
id: GO:0034087
name: establishment of mitotic sister chromatid cohesion
namespace: biological_process
def: "The process in which the sister chromatids of a replicated chromosome become joined along the entire length of the chromosome during S phase during a mitotic cell cycle." [GOC:mah]
is_a: GO:0034085 ! establishment of sister chromatid cohesion
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:0007064 ! mitotic sister chromatid cohesion

[Term]
id: GO:0034088
name: maintenance of mitotic sister chromatid cohesion
namespace: biological_process
def: "The process in which the association between sister chromatids of a replicated chromosome is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a mitotic cell cycle." [GOC:mah]
synonym: "mitotic cohesion stability" RELATED []
is_a: GO:0034086 ! maintenance of sister chromatid cohesion
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:0007064 ! mitotic sister chromatid cohesion

[Term]
id: GO:0034089
name: establishment of meiotic sister chromatid cohesion
namespace: biological_process
def: "The process in which the sister chromatids of a replicated chromosome become joined along the entire length of the chromosome during S phase during a meiotic cell cycle." [GOC:mah]
is_a: GO:0034085 ! establishment of sister chromatid cohesion
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0051177 ! meiotic sister chromatid cohesion

[Term]
id: GO:0034090
name: maintenance of meiotic sister chromatid cohesion
namespace: biological_process
def: "The process in which the association between sister chromatids of a replicated chromosome is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a meiotic cell cycle." [GOC:mah]
is_a: GO:0034086 ! maintenance of sister chromatid cohesion
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0051177 ! meiotic sister chromatid cohesion

[Term]
id: GO:0034091
name: regulation of maintenance of sister chromatid cohesion
namespace: biological_process
def: "Any process that modulates the extent to which the association between sister chromatids of a replicated chromosome is maintained." [GOC:mah, GOC:vw]
is_a: GO:0007063 ! regulation of sister chromatid cohesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034086 ! maintenance of sister chromatid cohesion
relationship: regulates GO:0034086 ! maintenance of sister chromatid cohesion

[Term]
id: GO:0034092
name: negative regulation of maintenance of sister chromatid cohesion
namespace: biological_process
def: "Any process that decreases the extent to which the association between sister chromatids of a replicated chromosome is maintained." [GOC:mah, GOC:vw]
is_a: GO:0034091 ! regulation of maintenance of sister chromatid cohesion
is_a: GO:0045875 ! negative regulation of sister chromatid cohesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034086 ! maintenance of sister chromatid cohesion
relationship: negatively_regulates GO:0034086 ! maintenance of sister chromatid cohesion

[Term]
id: GO:0034093
name: positive regulation of maintenance of sister chromatid cohesion
namespace: biological_process
def: "Any process that increases the extent to which the association between sister chromatids of a replicated chromosome is maintained." [GOC:mah, GOC:vw]
is_a: GO:0034091 ! regulation of maintenance of sister chromatid cohesion
is_a: GO:0045876 ! positive regulation of sister chromatid cohesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034086 ! maintenance of sister chromatid cohesion
relationship: positively_regulates GO:0034086 ! maintenance of sister chromatid cohesion

[Term]
id: GO:0034094
name: regulation of maintenance of meiotic sister chromatid cohesion
namespace: biological_process
def: "Any process that modulates the extent to which the association between sister chromatids of a replicated chromosome is maintained during a meiotic cell cycle." [GOC:mah, GOC:vw]
is_a: GO:0034091 ! regulation of maintenance of sister chromatid cohesion
is_a: GO:0040020 ! regulation of meiotic nuclear division
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034090 ! maintenance of meiotic sister chromatid cohesion
relationship: regulates GO:0034090 ! maintenance of meiotic sister chromatid cohesion

[Term]
id: GO:0034095
name: negative regulation of maintenance of meiotic sister chromatid cohesion
namespace: biological_process
def: "Any process that decreases the extent to which the association between sister chromatids of a replicated chromosome is maintained during a meiotic cell cycle." [GOC:mah, GOC:vw]
is_a: GO:0034092 ! negative regulation of maintenance of sister chromatid cohesion
is_a: GO:0034094 ! regulation of maintenance of meiotic sister chromatid cohesion
is_a: GO:0045835 ! negative regulation of meiotic nuclear division
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034090 ! maintenance of meiotic sister chromatid cohesion
relationship: negatively_regulates GO:0034090 ! maintenance of meiotic sister chromatid cohesion

[Term]
id: GO:0034096
name: positive regulation of maintenance of meiotic sister chromatid cohesion
namespace: biological_process
def: "Any process that increases the extent to which the association between sister chromatids of a replicated chromosome is maintained during a meiotic cell cycle." [GOC:mah, GOC:vw]
is_a: GO:0034093 ! positive regulation of maintenance of sister chromatid cohesion
is_a: GO:0034094 ! regulation of maintenance of meiotic sister chromatid cohesion
is_a: GO:0045836 ! positive regulation of meiotic nuclear division
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034090 ! maintenance of meiotic sister chromatid cohesion
relationship: positively_regulates GO:0034090 ! maintenance of meiotic sister chromatid cohesion

[Term]
id: GO:0034097
name: response to cytokine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:sl]
synonym: "response to cytokine stimulus" EXACT [GOC:dos]
is_a: GO:0010033 ! response to organic substance

[Term]
id: GO:0034098
name: VCP-NPL4-UFD1 AAA ATPase complex
namespace: cellular_component
def: "A multiprotein ATPase complex required for the efficient dislocation of ER-lumenal degradation substrates, and their subsequent proteolysis by the proteasome. In budding yeast, this complex includes Cdc48p, Npl4p and Ufd1p proteins. In mammals, this complex includes a hexamer of VCP/p97 (a cytosolic ATPase) and trimers of each of its cofactors UFD1L and NPL4 (NPLOC4) (e.g. a 6:3:3 stoichiometry)." [PMID:11813000, PMID:16179952]
synonym: "Cdc48p-Npl4p-Ufd1p AAA ATPase complex" NARROW []
synonym: "p97-Ufd1-Npl4 complex" EXACT [PMID:12847084]
is_a: GO:0044432 ! endoplasmic reticulum part
is_a: GO:0098796 ! membrane protein complex
relationship: has_part GO:0036501 ! UFD1-NPL4 complex
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane

[Term]
id: GO:0034099
name: luminal surveillance complex
namespace: cellular_component
def: "A multiprotein complex that recognizes ERAD-luminal misfolded substrates and brings them to the ubiquitination/extraction machinery. In yeast, this complex consists of Yos9p, Kar2p and Hrd3p proteins." [PMID:16873065]
is_a: GO:0043234 ! protein complex
is_a: GO:0044432 ! endoplasmic reticulum part
relationship: part_of GO:0005788 ! endoplasmic reticulum lumen

[Term]
id: GO:0034101
name: erythrocyte homeostasis
namespace: biological_process
def: "Any process of regulating the production and elimination of erythrocytes within an organism." [GOC:add, PMID:10694114, PMID:14754397]
synonym: "RBC homeostasis" EXACT [CL:0000232]
synonym: "red blood cell homeostasis" EXACT [CL:0000232]
is_a: GO:0002262 ! myeloid cell homeostasis

[Term]
id: GO:0034102
name: erythrocyte clearance
namespace: biological_process
def: "The selective elimination of erythrocytes from the body by autoregulatory mechanisms." [GOC:add, PMID:12905029, PMID:14754397]
comment: Note that this term is intended for annotation of self-gene products that lead to elimination of erythrocytes without the involvement of a symbiont.
synonym: "neocytolysis" NARROW [PMID:14754397]
synonym: "RBC clearance" EXACT [CL:0000232]
synonym: "red blood cell clearance" EXACT [CL:0000232]
is_a: GO:0048771 ! tissue remodeling
relationship: part_of GO:0034101 ! erythrocyte homeostasis

[Term]
id: GO:0034103
name: regulation of tissue remodeling
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of tissue remodeling." [GOC:add]
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048771 ! tissue remodeling
relationship: regulates GO:0048771 ! tissue remodeling

[Term]
id: GO:0034104
name: negative regulation of tissue remodeling
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tissue remodeling." [GOC:add]
is_a: GO:0034103 ! regulation of tissue remodeling
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048771 ! tissue remodeling
relationship: negatively_regulates GO:0048771 ! tissue remodeling

[Term]
id: GO:0034105
name: positive regulation of tissue remodeling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of tissue remodeling." [GOC:add]
is_a: GO:0034103 ! regulation of tissue remodeling
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048771 ! tissue remodeling
relationship: positively_regulates GO:0048771 ! tissue remodeling

[Term]
id: GO:0034106
name: regulation of erythrocyte clearance
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of erythrocyte clearance." [GOC:add, PMID:12905029, PMID:14754397]
synonym: "regulation of neocytolysis" NARROW [PMID:14754397]
synonym: "regulation of RBC clearance" EXACT [CL:0000232]
synonym: "regulation of red blood cell clearance" EXACT [CL:0000232]
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0032844 ! regulation of homeostatic process
is_a: GO:0034103 ! regulation of tissue remodeling
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034102 ! erythrocyte clearance
relationship: regulates GO:0034102 ! erythrocyte clearance

[Term]
id: GO:0034107
name: negative regulation of erythrocyte clearance
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of erythrocyte clearance." [GOC:add, PMID:12905029, PMID:14754397]
synonym: "negative regulation of neocytolysis" NARROW [PMID:14754397]
synonym: "negative regulation of RBC clearance" EXACT [CL:0000232]
synonym: "negative regulation of red blood cell clearance" EXACT [CL:0000232]
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0032845 ! negative regulation of homeostatic process
is_a: GO:0034104 ! negative regulation of tissue remodeling
is_a: GO:0034106 ! regulation of erythrocyte clearance
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034102 ! erythrocyte clearance
relationship: negatively_regulates GO:0034102 ! erythrocyte clearance

[Term]
id: GO:0034108
name: positive regulation of erythrocyte clearance
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of erythrocyte clearance." [GOC:add, PMID:12905029, PMID:14754397]
synonym: "positive regulation of neocytolysis" NARROW [PMID:14754397]
synonym: "positive regulation of RBC clearance" EXACT [CL:0000232]
synonym: "positive regulation of red blood cell clearance" EXACT [CL:0000232]
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0032846 ! positive regulation of homeostatic process
is_a: GO:0034105 ! positive regulation of tissue remodeling
is_a: GO:0034106 ! regulation of erythrocyte clearance
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034102 ! erythrocyte clearance
relationship: positively_regulates GO:0034102 ! erythrocyte clearance

[Term]
id: GO:0034109
name: homotypic cell-cell adhesion
namespace: biological_process
def: "The attachment of a cell to a second cell of the identical type via adhesion molecules." [GOC:add]
comment: Note that this term is not synonymous with 'homophilic cell adhesion ; GO:0007156'; the process may occur by homophilic or heterophilic mechanisms.
is_a: GO:0016337 ! single organismal cell-cell adhesion

[Term]
id: GO:0034110
name: regulation of homotypic cell-cell adhesion
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of homotypic cell-cell adhesion." [GOC:add]
is_a: GO:0022407 ! regulation of cell-cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034109 ! homotypic cell-cell adhesion
relationship: regulates GO:0034109 ! homotypic cell-cell adhesion

[Term]
id: GO:0034111
name: negative regulation of homotypic cell-cell adhesion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of homotypic cell-cell adhesion." [GOC:add]
is_a: GO:0022408 ! negative regulation of cell-cell adhesion
is_a: GO:0034110 ! regulation of homotypic cell-cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034109 ! homotypic cell-cell adhesion
relationship: negatively_regulates GO:0034109 ! homotypic cell-cell adhesion

[Term]
id: GO:0034112
name: positive regulation of homotypic cell-cell adhesion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of homotypic cell-cell adhesion." [GOC:add]
is_a: GO:0022409 ! positive regulation of cell-cell adhesion
is_a: GO:0034110 ! regulation of homotypic cell-cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034109 ! homotypic cell-cell adhesion
relationship: positively_regulates GO:0034109 ! homotypic cell-cell adhesion

[Term]
id: GO:0034113
name: heterotypic cell-cell adhesion
namespace: biological_process
def: "The attachment of a cell to a cell of a different type via adhesion molecules." [GOC:add]
comment: Note that this term is not synonymous with 'heterophilic cell adhesion ; GO:0007157'; the process may occur by homophilic or heterophilic mechanisms.
is_a: GO:0016337 ! single organismal cell-cell adhesion

[Term]
id: GO:0034114
name: regulation of heterotypic cell-cell adhesion
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of heterotypic cell-cell adhesion." [GOC:add]
is_a: GO:0022407 ! regulation of cell-cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034113 ! heterotypic cell-cell adhesion
relationship: regulates GO:0034113 ! heterotypic cell-cell adhesion

[Term]
id: GO:0034115
name: negative regulation of heterotypic cell-cell adhesion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of heterotypic cell-cell adhesion." [GOC:add]
is_a: GO:0022408 ! negative regulation of cell-cell adhesion
is_a: GO:0034114 ! regulation of heterotypic cell-cell adhesion
is_a: GO:0070587 ! regulation of cell-cell adhesion involved in gastrulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034113 ! heterotypic cell-cell adhesion
relationship: negatively_regulates GO:0034113 ! heterotypic cell-cell adhesion

[Term]
id: GO:0034116
name: positive regulation of heterotypic cell-cell adhesion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of heterotypic cell-cell adhesion." [GOC:add]
is_a: GO:0022409 ! positive regulation of cell-cell adhesion
is_a: GO:0034114 ! regulation of heterotypic cell-cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034113 ! heterotypic cell-cell adhesion
relationship: positively_regulates GO:0034113 ! heterotypic cell-cell adhesion

[Term]
id: GO:0034117
name: erythrocyte aggregation
namespace: biological_process
def: "The adhesion of one erythrocyte to one or more other erythrocytes via adhesion molecules." [GOC:add, PMID:14631543]
synonym: "RBC aggregation" EXACT [CL:0000232]
synonym: "red blood cell aggregation" EXACT [CL:0000232]
is_a: GO:0034109 ! homotypic cell-cell adhesion

[Term]
id: GO:0034118
name: regulation of erythrocyte aggregation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of erythrocyte aggregation." [GOC:add]
synonym: "regulation of RBC aggregation" EXACT [CL:0000232]
synonym: "regulation of red blood cell aggregation" EXACT [CL:0000232]
is_a: GO:0034110 ! regulation of homotypic cell-cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034117 ! erythrocyte aggregation
relationship: regulates GO:0034117 ! erythrocyte aggregation

[Term]
id: GO:0034119
name: negative regulation of erythrocyte aggregation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of erythrocyte aggregation." [GOC:add]
synonym: "negative regulation of RBC aggregation" EXACT [CL:0000232]
synonym: "negative regulation of red blood cell aggregation" EXACT [CL:0000232]
is_a: GO:0034111 ! negative regulation of homotypic cell-cell adhesion
is_a: GO:0034118 ! regulation of erythrocyte aggregation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034117 ! erythrocyte aggregation
relationship: negatively_regulates GO:0034117 ! erythrocyte aggregation

[Term]
id: GO:0034120
name: positive regulation of erythrocyte aggregation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of erythrocyte aggregation." [GOC:add]
synonym: "positive regulation of RBC aggregation" EXACT [CL:0000232]
synonym: "positive regulation of red blood cell aggregation" EXACT [CL:0000232]
is_a: GO:0034112 ! positive regulation of homotypic cell-cell adhesion
is_a: GO:0034118 ! regulation of erythrocyte aggregation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034117 ! erythrocyte aggregation
relationship: positively_regulates GO:0034117 ! erythrocyte aggregation

[Term]
id: GO:0034121
name: regulation of toll-like receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "regulation of TLR signaling pathway" EXACT []
synonym: "regulation of toll-like receptor signalling pathway" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0045088 ! regulation of innate immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002224 ! toll-like receptor signaling pathway
relationship: regulates GO:0002224 ! toll-like receptor signaling pathway

[Term]
id: GO:0034122
name: negative regulation of toll-like receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "negative regulation of TLR signaling pathway" EXACT []
synonym: "negative regulation of toll-like receptor signalling pathway" EXACT []
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002224 ! toll-like receptor signaling pathway
relationship: negatively_regulates GO:0002224 ! toll-like receptor signaling pathway

[Term]
id: GO:0034123
name: positive regulation of toll-like receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "positive regulation of TLR signaling pathway" EXACT []
synonym: "positive regulation of toll-like receptor signalling pathway" EXACT []
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002224 ! toll-like receptor signaling pathway
relationship: positively_regulates GO:0002224 ! toll-like receptor signaling pathway

[Term]
id: GO:0034124
name: regulation of MyD88-dependent toll-like receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of MyD88-dependent toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "regulation ofMyD88-dependent TLR signaling pathway" EXACT []
synonym: "regulation ofMyD88-dependent toll-like receptor signalling pathway" EXACT []
is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002755 ! MyD88-dependent toll-like receptor signaling pathway
relationship: regulates GO:0002755 ! MyD88-dependent toll-like receptor signaling pathway

[Term]
id: GO:0034125
name: negative regulation of MyD88-dependent toll-like receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of MyD88-dependent toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "negative regulation of MyD88-dependent TLR signaling pathway" EXACT []
synonym: "negative regulation of MyD88-dependent toll-like receptor signalling pathway" EXACT []
is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway
is_a: GO:0034124 ! regulation of MyD88-dependent toll-like receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002755 ! MyD88-dependent toll-like receptor signaling pathway
relationship: negatively_regulates GO:0002755 ! MyD88-dependent toll-like receptor signaling pathway

[Term]
id: GO:0034126
name: positive regulation of MyD88-dependent toll-like receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of MyD88-dependent toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "positive regulation of MyD88-dependent TLR signaling pathway" EXACT []
synonym: "positive regulation of MyD88-dependent toll-like receptor signalling pathway" EXACT []
is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway
is_a: GO:0034124 ! regulation of MyD88-dependent toll-like receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002755 ! MyD88-dependent toll-like receptor signaling pathway
relationship: positively_regulates GO:0002755 ! MyD88-dependent toll-like receptor signaling pathway

[Term]
id: GO:0034127
name: regulation of MyD88-independent toll-like receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of MyD88-independent toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "regulation ofMyD88-independent TLR signaling pathway" EXACT []
synonym: "regulation ofMyD88-independent toll-like receptor signalling pathway" EXACT []
is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002756 ! MyD88-independent toll-like receptor signaling pathway
relationship: regulates GO:0002756 ! MyD88-independent toll-like receptor signaling pathway

[Term]
id: GO:0034128
name: negative regulation of MyD88-independent toll-like receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of MyD88-independent toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "negative regulation of MyD88-independent TLR signaling pathway" EXACT []
synonym: "negative regulation of MyD88-independent toll-like receptor signalling pathway" EXACT []
is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway
is_a: GO:0034127 ! regulation of MyD88-independent toll-like receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002756 ! MyD88-independent toll-like receptor signaling pathway
relationship: negatively_regulates GO:0002756 ! MyD88-independent toll-like receptor signaling pathway

[Term]
id: GO:0034129
name: positive regulation of MyD88-independent toll-like receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of MyD88-independent toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "positive regulation of MyD88-independent TLR signaling pathway" EXACT []
synonym: "positive regulation of MyD88-independent toll-like receptor" EXACT []
synonym: "positive regulation of MyD88-independent toll-like receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway
is_a: GO:0034127 ! regulation of MyD88-independent toll-like receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002756 ! MyD88-independent toll-like receptor signaling pathway
relationship: positively_regulates GO:0002756 ! MyD88-independent toll-like receptor signaling pathway

[Term]
id: GO:0034130
name: toll-like receptor 1 signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 1." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "TLR1 signaling pathway" EXACT []
synonym: "toll-like receptor 1 signalling pathway" EXACT []
xref: Reactome:REACT_101461 "Toll Like Receptor TLR1:TLR2 Cascade, Saccharomyces cerevisiae"
xref: Reactome:REACT_103415 "Toll Like Receptor TLR1:TLR2 Cascade, Taeniopygia guttata"
xref: Reactome:REACT_104469 "Toll Like Receptor TLR1:TLR2 Cascade, Dictyostelium discoideum"
xref: Reactome:REACT_107561 "Toll Like Receptor TLR1:TLR2 Cascade, Xenopus tropicalis"
xref: Reactome:REACT_109090 "Toll Like Receptor TLR1:TLR2 Cascade, Danio rerio"
xref: Reactome:REACT_28649 "Toll Like Receptor TLR1:TLR2 Cascade, Schizosaccharomyces pombe"
xref: Reactome:REACT_34248 "Toll Like Receptor TLR1:TLR2 Cascade, Caenorhabditis elegans"
xref: Reactome:REACT_8005 "Toll Like Receptor TLR1:TLR2 Cascade, Homo sapiens"
xref: Reactome:REACT_81145 "Toll Like Receptor TLR1:TLR2 Cascade, Gallus gallus"
xref: Reactome:REACT_82587 "Toll Like Receptor TLR1:TLR2 Cascade, Sus scrofa"
xref: Reactome:REACT_85535 "Toll Like Receptor TLR1:TLR2 Cascade, Rattus norvegicus"
xref: Reactome:REACT_88809 "Toll Like Receptor TLR1:TLR2 Cascade, Mus musculus"
xref: Reactome:REACT_89891 "Toll Like Receptor TLR1:TLR2 Cascade, Arabidopsis thaliana"
xref: Reactome:REACT_91544 "Toll Like Receptor TLR1:TLR2 Cascade, Oryza sativa"
xref: Reactome:REACT_91660 "Toll Like Receptor TLR1:TLR2 Cascade, Canis familiaris"
xref: Reactome:REACT_91838 "Toll Like Receptor TLR1:TLR2 Cascade, Drosophila melanogaster"
xref: Reactome:REACT_95436 "Toll Like Receptor TLR1:TLR2 Cascade, Bos taurus"
is_a: GO:0002224 ! toll-like receptor signaling pathway

[Term]
id: GO:0034131
name: regulation of toll-like receptor 1 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 1 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "regulation of TLR1 signaling pathway" EXACT []
synonym: "regulation of toll-like receptor 1 signalling pathway" EXACT []
is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034130 ! toll-like receptor 1 signaling pathway
relationship: regulates GO:0034130 ! toll-like receptor 1 signaling pathway

[Term]
id: GO:0034132
name: negative regulation of toll-like receptor 1 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 1 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "negative regulation of TLR1 signaling pathway" EXACT []
synonym: "negative regulation of toll-like receptor 1 signalling pathway" EXACT []
is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway
is_a: GO:0034131 ! regulation of toll-like receptor 1 signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034130 ! toll-like receptor 1 signaling pathway
relationship: negatively_regulates GO:0034130 ! toll-like receptor 1 signaling pathway

[Term]
id: GO:0034133
name: positive regulation of toll-like receptor 1 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 1 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "positive regulation of TLR1 signaling pathway" EXACT []
synonym: "positive regulation of toll-like receptor 1 signalling pathway" EXACT []
is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway
is_a: GO:0034131 ! regulation of toll-like receptor 1 signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034130 ! toll-like receptor 1 signaling pathway
relationship: positively_regulates GO:0034130 ! toll-like receptor 1 signaling pathway

[Term]
id: GO:0034134
name: toll-like receptor 2 signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 2." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "TLR2 signaling pathway" EXACT []
synonym: "toll-like receptor 2 signalling pathway" EXACT []
xref: Reactome:REACT_101124 "Toll Like Receptor 2 (TLR2) Cascade, Dictyostelium discoideum"
xref: Reactome:REACT_109018 "Toll Like Receptor 2 (TLR2) Cascade, Drosophila melanogaster"
xref: Reactome:REACT_109921 "Toll Like Receptor 2 (TLR2) Cascade, Xenopus tropicalis"
xref: Reactome:REACT_110359 "Toll Like Receptor 2 (TLR2) Cascade, Danio rerio"
xref: Reactome:REACT_25164 "TLR2 subfamily cascade, Gallus gallus"
xref: Reactome:REACT_29705 "Toll Like Receptor 2 (TLR2) Cascade, Oryza sativa"
xref: Reactome:REACT_30806 "Toll Like Receptor 2 (TLR2) Cascade, Taeniopygia guttata"
xref: Reactome:REACT_31781 "Toll Like Receptor 2 (TLR2) Cascade, Bos taurus"
xref: Reactome:REACT_32312 "Toll Like Receptor 2 (TLR2) Cascade, Saccharomyces cerevisiae"
xref: Reactome:REACT_65361 "Toll Like Receptor 2 (TLR2) Cascade, Gallus gallus"
xref: Reactome:REACT_7980 "Toll Like Receptor 2 (TLR2) Cascade, Homo sapiens"
xref: Reactome:REACT_81077 "Toll Like Receptor 2 (TLR2) Cascade, Canis familiaris"
xref: Reactome:REACT_91964 "Toll Like Receptor 2 (TLR2) Cascade, Mus musculus"
xref: Reactome:REACT_92534 "Toll Like Receptor 2 (TLR2) Cascade, Rattus norvegicus"
xref: Reactome:REACT_92918 "Toll Like Receptor 2 (TLR2) Cascade, Arabidopsis thaliana"
xref: Reactome:REACT_94528 "Toll Like Receptor 2 (TLR2) Cascade, Caenorhabditis elegans"
xref: Reactome:REACT_97650 "Toll Like Receptor 2 (TLR2) Cascade, Sus scrofa"
xref: Reactome:REACT_98284 "Toll Like Receptor 2 (TLR2) Cascade, Schizosaccharomyces pombe"
is_a: GO:0002224 ! toll-like receptor signaling pathway

[Term]
id: GO:0034135
name: regulation of toll-like receptor 2 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 2 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "regulation of TLR2 signaling pathway" EXACT []
synonym: "regulation of toll-like receptor 2 signalling pathway" EXACT []
is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034134 ! toll-like receptor 2 signaling pathway
relationship: regulates GO:0034134 ! toll-like receptor 2 signaling pathway

[Term]
id: GO:0034136
name: negative regulation of toll-like receptor 2 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 2 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "negative regulation of TLR2 signaling pathway" EXACT []
synonym: "negative regulation of toll-like receptor 2 signalling pathway" EXACT []
is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway
is_a: GO:0034135 ! regulation of toll-like receptor 2 signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034134 ! toll-like receptor 2 signaling pathway
relationship: negatively_regulates GO:0034134 ! toll-like receptor 2 signaling pathway

[Term]
id: GO:0034137
name: positive regulation of toll-like receptor 2 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 2 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "positive regulation of TLR2 signaling pathway" EXACT []
synonym: "positive regulation of toll-like receptor 2 signalling pathway" EXACT []
is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway
is_a: GO:0034135 ! regulation of toll-like receptor 2 signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034134 ! toll-like receptor 2 signaling pathway
relationship: positively_regulates GO:0034134 ! toll-like receptor 2 signaling pathway

[Term]
id: GO:0034138
name: toll-like receptor 3 signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 3." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "TLR3 signaling pathway" EXACT []
synonym: "toll-like receptor 3 signalling pathway" EXACT []
xref: Reactome:REACT_105689 "Toll Like Receptor 3 (TLR3) Cascade, Caenorhabditis elegans"
xref: Reactome:REACT_24931 "TLR3 cascade, Gallus gallus"
xref: Reactome:REACT_28258 "Toll Like Receptor 3 (TLR3) Cascade, Mus musculus"
xref: Reactome:REACT_33471 "Toll Like Receptor 3 (TLR3) Cascade, Xenopus tropicalis"
xref: Reactome:REACT_34013 "Toll Like Receptor 3 (TLR3) Cascade, Oryza sativa"
xref: Reactome:REACT_6783 "Toll Like Receptor 3 (TLR3) Cascade, Homo sapiens"
xref: Reactome:REACT_77162 "Toll Like Receptor 3 (TLR3) Cascade, Taeniopygia guttata"
xref: Reactome:REACT_78042 "Toll Like Receptor 3 (TLR3) Cascade, Bos taurus"
xref: Reactome:REACT_82524 "Toll Like Receptor 3 (TLR3) Cascade, Danio rerio"
xref: Reactome:REACT_82653 "Toll Like Receptor 3 (TLR3) Cascade, Dictyostelium discoideum"
xref: Reactome:REACT_87070 "Toll Like Receptor 3 (TLR3) Cascade, Arabidopsis thaliana"
xref: Reactome:REACT_89220 "Toll Like Receptor 3 (TLR3) Cascade, Sus scrofa"
xref: Reactome:REACT_89246 "Toll Like Receptor 3 (TLR3) Cascade, Schizosaccharomyces pombe"
xref: Reactome:REACT_91126 "Toll Like Receptor 3 (TLR3) Cascade, Gallus gallus"
xref: Reactome:REACT_92227 "Toll Like Receptor 3 (TLR3) Cascade, Canis familiaris"
xref: Reactome:REACT_96401 "Toll Like Receptor 3 (TLR3) Cascade, Saccharomyces cerevisiae"
xref: Reactome:REACT_98010 "Toll Like Receptor 3 (TLR3) Cascade, Rattus norvegicus"
xref: Reactome:REACT_99649 "Toll Like Receptor 3 (TLR3) Cascade, Drosophila melanogaster"
is_a: GO:0002224 ! toll-like receptor signaling pathway

[Term]
id: GO:0034139
name: regulation of toll-like receptor 3 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 3 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "regulation of TLR3 signaling pathway" EXACT []
synonym: "regulation of toll-like receptor 3 signalling pathway" EXACT []
is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034138 ! toll-like receptor 3 signaling pathway
relationship: regulates GO:0034138 ! toll-like receptor 3 signaling pathway

[Term]
id: GO:0034140
name: negative regulation of toll-like receptor 3 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 3 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "negative regulation of TLR3 signaling pathway" EXACT []
synonym: "negative regulation of toll-like receptor 3 signalling pathway" EXACT []
is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway
is_a: GO:0034139 ! regulation of toll-like receptor 3 signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034138 ! toll-like receptor 3 signaling pathway
relationship: negatively_regulates GO:0034138 ! toll-like receptor 3 signaling pathway

[Term]
id: GO:0034141
name: positive regulation of toll-like receptor 3 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 3 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "positive regulation of TLR3 signaling pathway" EXACT []
synonym: "positive regulation of toll-like receptor 3 signalling pathway" EXACT []
is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway
is_a: GO:0034139 ! regulation of toll-like receptor 3 signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034138 ! toll-like receptor 3 signaling pathway
relationship: positively_regulates GO:0034138 ! toll-like receptor 3 signaling pathway

[Term]
id: GO:0034142
name: toll-like receptor 4 signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 4." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "TLR4 signaling pathway" EXACT []
synonym: "toll-like receptor 4 signalling pathway" EXACT []
xref: Reactome:REACT_102390 "Activated TLR4 signalling, Gallus gallus"
xref: Reactome:REACT_104826 "Activated TLR4 signalling, Xenopus tropicalis"
xref: Reactome:REACT_105760 "Activated TLR4 signalling, Dictyostelium discoideum"
xref: Reactome:REACT_107031 "Activated TLR4 signalling, Danio rerio"
xref: Reactome:REACT_107654 "Activated TLR4 signalling, Canis familiaris"
xref: Reactome:REACT_108240 "Activated TLR4 signalling, Mus musculus"
xref: Reactome:REACT_109693 "Activated TLR4 signalling, Rattus norvegicus"
xref: Reactome:REACT_25254 "TLR4 cascade, Gallus gallus"
xref: Reactome:REACT_32317 "Activated TLR4 signalling, Taeniopygia guttata"
xref: Reactome:REACT_32722 "Activated TLR4 signalling, Bos taurus"
xref: Reactome:REACT_33197 "Activated TLR4 signalling, Arabidopsis thaliana"
xref: Reactome:REACT_6890 "Activated TLR4 signalling, Homo sapiens"
xref: Reactome:REACT_78076 "Activated TLR4 signalling, Sus scrofa"
xref: Reactome:REACT_78833 "Activated TLR4 signalling, Caenorhabditis elegans"
xref: Reactome:REACT_81991 "Activated TLR4 signalling, Schizosaccharomyces pombe"
xref: Reactome:REACT_87317 "Activated TLR4 signalling, Saccharomyces cerevisiae"
xref: Reactome:REACT_90914 "Activated TLR4 signalling, Drosophila melanogaster"
xref: Reactome:REACT_91273 "Activated TLR4 signalling, Oryza sativa"
is_a: GO:0002224 ! toll-like receptor signaling pathway

[Term]
id: GO:0034143
name: regulation of toll-like receptor 4 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 4 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "regulation of TLR4 signaling pathway" EXACT []
synonym: "regulation of toll-like receptor 4 signalling pathway" EXACT []
is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034142 ! toll-like receptor 4 signaling pathway
relationship: regulates GO:0034142 ! toll-like receptor 4 signaling pathway

[Term]
id: GO:0034144
name: negative regulation of toll-like receptor 4 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 4 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "negative regulation of TLR4 signaling pathway" EXACT []
synonym: "negative regulation of toll-like receptor 4 signalling pathway" EXACT []
is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway
is_a: GO:0034143 ! regulation of toll-like receptor 4 signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034142 ! toll-like receptor 4 signaling pathway
relationship: negatively_regulates GO:0034142 ! toll-like receptor 4 signaling pathway

[Term]
id: GO:0034145
name: positive regulation of toll-like receptor 4 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 4 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "positive regulation of TLR4 signaling pathway" EXACT []
synonym: "positive regulation of toll-like receptor 4 signalling pathway" EXACT []
is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway
is_a: GO:0034143 ! regulation of toll-like receptor 4 signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034142 ! toll-like receptor 4 signaling pathway
relationship: positively_regulates GO:0034142 ! toll-like receptor 4 signaling pathway

[Term]
id: GO:0034146
name: toll-like receptor 5 signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 5." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "TLR5 signaling pathway" EXACT []
synonym: "toll-like receptor 5 signalling pathway" EXACT []
xref: Reactome:REACT_27287 "TLR5 cascade, Gallus gallus"
is_a: GO:0002224 ! toll-like receptor signaling pathway

[Term]
id: GO:0034147
name: regulation of toll-like receptor 5 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 5 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "regulation of TLR5 signaling pathway" EXACT []
synonym: "regulation of toll-like receptor 5 signalling pathway" EXACT []
is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034146 ! toll-like receptor 5 signaling pathway
relationship: regulates GO:0034146 ! toll-like receptor 5 signaling pathway

[Term]
id: GO:0034148
name: negative regulation of toll-like receptor 5 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 5 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "negative regulation of TLR5 signaling pathway" EXACT []
synonym: "negative regulation of toll-like receptor 5 signalling pathway" EXACT []
is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway
is_a: GO:0034147 ! regulation of toll-like receptor 5 signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034146 ! toll-like receptor 5 signaling pathway
relationship: negatively_regulates GO:0034146 ! toll-like receptor 5 signaling pathway

[Term]
id: GO:0034149
name: positive regulation of toll-like receptor 5 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 5 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "positive regulation of TLR5 signaling pathway" EXACT []
synonym: "positive regulation of toll-like receptor 5 signalling pathway" EXACT []
is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway
is_a: GO:0034147 ! regulation of toll-like receptor 5 signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034146 ! toll-like receptor 5 signaling pathway
relationship: positively_regulates GO:0034146 ! toll-like receptor 5 signaling pathway

[Term]
id: GO:0034150
name: toll-like receptor 6 signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 6." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "TLR6 signaling pathway" EXACT []
synonym: "toll-like receptor 6 signalling pathway" EXACT []
is_a: GO:0002224 ! toll-like receptor signaling pathway

[Term]
id: GO:0034151
name: regulation of toll-like receptor 6 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 6 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "regulation of TLR6 signaling pathway" EXACT []
synonym: "regulation of toll-like receptor 6 signalling pathway" EXACT []
is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034150 ! toll-like receptor 6 signaling pathway
relationship: regulates GO:0034150 ! toll-like receptor 6 signaling pathway

[Term]
id: GO:0034152
name: negative regulation of toll-like receptor 6 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 6 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "negative regulation of TLR6 signaling pathway" EXACT []
synonym: "negative regulation of toll-like receptor 6 signalling pathway" EXACT []
is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway
is_a: GO:0034151 ! regulation of toll-like receptor 6 signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034150 ! toll-like receptor 6 signaling pathway
relationship: negatively_regulates GO:0034150 ! toll-like receptor 6 signaling pathway

[Term]
id: GO:0034153
name: positive regulation of toll-like receptor 6 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 6 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "positive regulation of TLR6 signaling pathway" EXACT []
synonym: "positive regulation of toll-like receptor 6 signalling pathway" EXACT []
is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway
is_a: GO:0034151 ! regulation of toll-like receptor 6 signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034150 ! toll-like receptor 6 signaling pathway
relationship: positively_regulates GO:0034150 ! toll-like receptor 6 signaling pathway

[Term]
id: GO:0034154
name: toll-like receptor 7 signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 7." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "TLR7 signaling pathway" EXACT []
synonym: "toll-like receptor 7 signalling pathway" EXACT []
xref: Reactome:REACT_27266 "TLR7 cascade, Gallus gallus"
is_a: GO:0002224 ! toll-like receptor signaling pathway

[Term]
id: GO:0034155
name: regulation of toll-like receptor 7 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 7 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "regulation of TLR7 signaling pathway" EXACT []
synonym: "regulation of toll-like receptor 7 signalling pathway" EXACT []
is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034154 ! toll-like receptor 7 signaling pathway
relationship: regulates GO:0034154 ! toll-like receptor 7 signaling pathway

[Term]
id: GO:0034156
name: negative regulation of toll-like receptor 7 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 7 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "negative regulation of TLR7 signaling pathway" EXACT []
synonym: "negative regulation of toll-like receptor 7 signalling pathway" EXACT []
is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway
is_a: GO:0034155 ! regulation of toll-like receptor 7 signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034154 ! toll-like receptor 7 signaling pathway
relationship: negatively_regulates GO:0034154 ! toll-like receptor 7 signaling pathway

[Term]
id: GO:0034157
name: positive regulation of toll-like receptor 7 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 7 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "positive regulation of TLR7 signaling pathway" EXACT []
synonym: "positive regulation of toll-like receptor 7 signalling pathway" EXACT []
is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway
is_a: GO:0034155 ! regulation of toll-like receptor 7 signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034154 ! toll-like receptor 7 signaling pathway
relationship: positively_regulates GO:0034154 ! toll-like receptor 7 signaling pathway

[Term]
id: GO:0034158
name: toll-like receptor 8 signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 8." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "TLR8 signaling pathway" EXACT []
synonym: "toll-like receptor 8 signalling pathway" EXACT []
is_a: GO:0002224 ! toll-like receptor signaling pathway

[Term]
id: GO:0034159
name: regulation of toll-like receptor 8 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 8 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "regulation of TLR8 signaling pathway" EXACT []
synonym: "regulation of toll-like receptor 8 signalling pathway" EXACT []
is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034158 ! toll-like receptor 8 signaling pathway
relationship: regulates GO:0034158 ! toll-like receptor 8 signaling pathway

[Term]
id: GO:0034160
name: negative regulation of toll-like receptor 8 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 8 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "negative regulation of TLR8 signaling pathway" EXACT []
synonym: "negative regulation of toll-like receptor 8 signalling pathway" EXACT []
is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway
is_a: GO:0034159 ! regulation of toll-like receptor 8 signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034158 ! toll-like receptor 8 signaling pathway
relationship: negatively_regulates GO:0034158 ! toll-like receptor 8 signaling pathway

[Term]
id: GO:0034161
name: positive regulation of toll-like receptor 8 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 8 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "positive regulation of TLR8 signaling pathway" EXACT []
synonym: "positive regulation of toll-like receptor 8 signalling pathway" EXACT []
is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway
is_a: GO:0034159 ! regulation of toll-like receptor 8 signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034158 ! toll-like receptor 8 signaling pathway
relationship: positively_regulates GO:0034158 ! toll-like receptor 8 signaling pathway

[Term]
id: GO:0034162
name: toll-like receptor 9 signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 9." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "TLR9 signaling pathway" EXACT []
synonym: "toll-like receptor 9 signalling pathway" EXACT []
is_a: GO:0002224 ! toll-like receptor signaling pathway

[Term]
id: GO:0034163
name: regulation of toll-like receptor 9 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 9 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "regulation of TLR9 signaling pathway" EXACT []
synonym: "regulation of toll-like receptor 9 signalling pathway" EXACT []
is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034162 ! toll-like receptor 9 signaling pathway
relationship: regulates GO:0034162 ! toll-like receptor 9 signaling pathway

[Term]
id: GO:0034164
name: negative regulation of toll-like receptor 9 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 9 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "negative regulation of TLR9 signaling pathway" EXACT []
synonym: "negative regulation of toll-like receptor 9 signalling pathway" EXACT []
is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway
is_a: GO:0034163 ! regulation of toll-like receptor 9 signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034162 ! toll-like receptor 9 signaling pathway
relationship: negatively_regulates GO:0034162 ! toll-like receptor 9 signaling pathway

[Term]
id: GO:0034165
name: positive regulation of toll-like receptor 9 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 9 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "positive regulation of TLR9 signaling pathway" EXACT []
synonym: "positive regulation of toll-like receptor 9 signalling pathway" EXACT []
is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway
is_a: GO:0034163 ! regulation of toll-like receptor 9 signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034162 ! toll-like receptor 9 signaling pathway
relationship: positively_regulates GO:0034162 ! toll-like receptor 9 signaling pathway

[Term]
id: GO:0034166
name: toll-like receptor 10 signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 10." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "TLR10 signaling pathway" EXACT []
synonym: "toll-like receptor 10 signalling pathway" EXACT []
is_a: GO:0002224 ! toll-like receptor signaling pathway

[Term]
id: GO:0034167
name: regulation of toll-like receptor 10 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 10 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "regulation of TLR10 signaling pathway" EXACT []
synonym: "regulation of toll-like receptor 10 signalling pathway" EXACT []
is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034166 ! toll-like receptor 10 signaling pathway
relationship: regulates GO:0034166 ! toll-like receptor 10 signaling pathway

[Term]
id: GO:0034168
name: negative regulation of toll-like receptor 10 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 10 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "negative regulation of TLR10 signaling pathway" EXACT []
synonym: "negative regulation of toll-like receptor 10 signalling pathway" EXACT []
is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway
is_a: GO:0034167 ! regulation of toll-like receptor 10 signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034166 ! toll-like receptor 10 signaling pathway
relationship: negatively_regulates GO:0034166 ! toll-like receptor 10 signaling pathway

[Term]
id: GO:0034169
name: positive regulation of toll-like receptor 10 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 10 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "positive regulation of TLR10 signaling pathway" EXACT []
synonym: "positive regulation of toll-like receptor 10 signalling pathway" EXACT []
is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway
is_a: GO:0034167 ! regulation of toll-like receptor 10 signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034166 ! toll-like receptor 10 signaling pathway
relationship: positively_regulates GO:0034166 ! toll-like receptor 10 signaling pathway

[Term]
id: GO:0034170
name: toll-like receptor 11 signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 11." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "TLR11 signaling pathway" EXACT []
synonym: "toll-like receptor 11 signalling pathway" EXACT []
is_a: GO:0002224 ! toll-like receptor signaling pathway

[Term]
id: GO:0034171
name: regulation of toll-like receptor 11 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 11 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "regulation of TLR11 signaling pathway" EXACT []
synonym: "regulation of toll-like receptor 11 signalling pathway" EXACT []
is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034170 ! toll-like receptor 11 signaling pathway
relationship: regulates GO:0034170 ! toll-like receptor 11 signaling pathway

[Term]
id: GO:0034172
name: negative regulation of toll-like receptor 11 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 11 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "negative regulation of TLR11 signaling pathway" EXACT []
synonym: "negative regulation of toll-like receptor 11 signalling pathway" EXACT []
is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway
is_a: GO:0034171 ! regulation of toll-like receptor 11 signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034170 ! toll-like receptor 11 signaling pathway
relationship: negatively_regulates GO:0034170 ! toll-like receptor 11 signaling pathway

[Term]
id: GO:0034173
name: positive regulation of toll-like receptor 11 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 11 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "positive regulation of TLR11 signaling pathway" EXACT []
synonym: "positive regulation of toll-like receptor 11 signalling pathway" EXACT []
is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway
is_a: GO:0034171 ! regulation of toll-like receptor 11 signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034170 ! toll-like receptor 11 signaling pathway
relationship: positively_regulates GO:0034170 ! toll-like receptor 11 signaling pathway

[Term]
id: GO:0034174
name: toll-like receptor 12 signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 12." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "TLR12 signaling pathway" EXACT []
synonym: "toll-like receptor 12 signalling pathway" EXACT []
is_a: GO:0002224 ! toll-like receptor signaling pathway

[Term]
id: GO:0034175
name: regulation of toll-like receptor 12 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 12 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "regulation of TLR12 signaling pathway" EXACT []
synonym: "regulation of toll-like receptor 12 signalling pathway" EXACT []
is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034174 ! toll-like receptor 12 signaling pathway
relationship: regulates GO:0034174 ! toll-like receptor 12 signaling pathway

[Term]
id: GO:0034176
name: negative regulation of toll-like receptor 12 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 12 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "negative regulation of TLR12 signaling pathway" EXACT []
synonym: "negative regulation of toll-like receptor 12 signalling pathway" EXACT []
is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway
is_a: GO:0034175 ! regulation of toll-like receptor 12 signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034174 ! toll-like receptor 12 signaling pathway
relationship: negatively_regulates GO:0034174 ! toll-like receptor 12 signaling pathway

[Term]
id: GO:0034177
name: positive regulation of toll-like receptor 12 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 12 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "positive regulation of TLR12 signaling pathway" EXACT []
synonym: "positive regulation of toll-like receptor 12 signalling pathway" EXACT []
is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway
is_a: GO:0034175 ! regulation of toll-like receptor 12 signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034174 ! toll-like receptor 12 signaling pathway
relationship: positively_regulates GO:0034174 ! toll-like receptor 12 signaling pathway

[Term]
id: GO:0034178
name: toll-like receptor 13 signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 13." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "TLR13 signaling pathway" EXACT []
synonym: "toll-like receptor 13 signalling pathway" EXACT []
is_a: GO:0002224 ! toll-like receptor signaling pathway

[Term]
id: GO:0034179
name: regulation of toll-like receptor 13 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 13 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "regulation of TLR13 signaling pathway" EXACT []
synonym: "regulation of toll-like receptor 13 signalling pathway" EXACT []
is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034178 ! toll-like receptor 13 signaling pathway
relationship: regulates GO:0034178 ! toll-like receptor 13 signaling pathway

[Term]
id: GO:0034180
name: negative regulation of toll-like receptor 13 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 13 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "negative regulation of TLR13 signaling pathway" EXACT []
synonym: "negative regulation of toll-like receptor 13 signalling pathway" EXACT []
is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway
is_a: GO:0034179 ! regulation of toll-like receptor 13 signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034178 ! toll-like receptor 13 signaling pathway
relationship: negatively_regulates GO:0034178 ! toll-like receptor 13 signaling pathway

[Term]
id: GO:0034181
name: positive regulation of toll-like receptor 13 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 13 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "positive regulation of TLR13 signaling pathway" EXACT []
synonym: "positive regulation of toll-like receptor 13 signalling pathway" EXACT []
is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway
is_a: GO:0034179 ! regulation of toll-like receptor 13 signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034178 ! toll-like receptor 13 signaling pathway
relationship: positively_regulates GO:0034178 ! toll-like receptor 13 signaling pathway

[Term]
id: GO:0034182
name: regulation of maintenance of mitotic sister chromatid cohesion
namespace: biological_process
def: "Any process that modulates the extent to which the association between sister chromatids of a replicated chromosome is maintained during a mitotic cell cycle." [GOC:mah, GOC:vw]
is_a: GO:0033047 ! regulation of mitotic sister chromatid segregation
is_a: GO:0034091 ! regulation of maintenance of sister chromatid cohesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034088 ! maintenance of mitotic sister chromatid cohesion
relationship: regulates GO:0034088 ! maintenance of mitotic sister chromatid cohesion

[Term]
id: GO:0034183
name: negative regulation of maintenance of mitotic sister chromatid cohesion
namespace: biological_process
def: "Any process that decreases the extent to which the association between sister chromatids of a replicated chromosome is maintained during a mitotic cell cycle." [GOC:mah, GOC:vw]
is_a: GO:0033048 ! negative regulation of mitotic sister chromatid segregation
is_a: GO:0034092 ! negative regulation of maintenance of sister chromatid cohesion
is_a: GO:0034182 ! regulation of maintenance of mitotic sister chromatid cohesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034088 ! maintenance of mitotic sister chromatid cohesion
relationship: negatively_regulates GO:0034088 ! maintenance of mitotic sister chromatid cohesion

[Term]
id: GO:0034184
name: positive regulation of maintenance of mitotic sister chromatid cohesion
namespace: biological_process
def: "Any process that increases the extent to which the association between sister chromatids of a replicated chromosome is maintained during a mitotic cell cycle." [GOC:mah, GOC:vw]
is_a: GO:0034093 ! positive regulation of maintenance of sister chromatid cohesion
is_a: GO:0034182 ! regulation of maintenance of mitotic sister chromatid cohesion
is_a: GO:0045840 ! positive regulation of mitotic nuclear division
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034088 ! maintenance of mitotic sister chromatid cohesion
relationship: positively_regulates GO:0034088 ! maintenance of mitotic sister chromatid cohesion

[Term]
id: GO:0034185
name: apolipoprotein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an apolipoprotein, the protein component of a lipoprotein complex." [GOC:BHF, GOC:rl]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0034186
name: apolipoprotein A-I binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with apolipoprotein A-I." [GOC:BHF, GOC:rl]
is_a: GO:0034185 ! apolipoprotein binding

[Term]
id: GO:0034187
name: obsolete apolipoprotein E binding
namespace: molecular_function
def: "OBSOLETE. Interacting selectively and non-covalently with apolipoprotein E." [GOC:BHF, GOC:rl]
comment: This term was made obsolete because it represents binding to an individual protein.
synonym: "apolipoprotein E binding" EXACT []
is_obsolete: true
replaced_by: GO:0034185

[Term]
id: GO:0034188
name: apolipoprotein A-I receptor activity
namespace: molecular_function
def: "Combining with apolipoprotein A-I and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, GOC:BHF, GOC:rl, GOC:signaling, PMID:16443932]
is_a: GO:0004888 ! transmembrane signaling receptor activity
is_a: GO:0030226 ! apolipoprotein receptor activity
relationship: has_part GO:0034186 ! apolipoprotein A-I binding
relationship: part_of GO:0038027 ! apolipoprotein A-I-mediated signaling pathway

[Term]
id: GO:0034189
name: very-low-density lipoprotein particle binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a very-low-density lipoprotein particle, a triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm." [GOC:BHF, GOC:mah]
synonym: "very-low-density lipoprotein binding" EXACT [GOC:bf, GOC:dph]
synonym: "VLDL binding" EXACT []
is_a: GO:0005515 ! protein binding
is_a: GO:0071813 ! lipoprotein particle binding

[Term]
id: GO:0034190
name: apolipoprotein receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an apolipoprotein receptor." [GOC:BHF, GOC:rl]
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0034191
name: apolipoprotein A-I receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an apolipoprotein A-I receptor." [GOC:BHF, GOC:rl]
comment: Note that this term is to be used only to annotate gene products that bind to lipid-free APOA1. For receptors that bind lipid-associated apolipoproteins (plasma lipoprotein particles), consider annotating to 'lipoprotein receptor activity ; GO:0030228' or its child terms.
is_a: GO:0034190 ! apolipoprotein receptor binding

[Term]
id: GO:0034192
name: D-galactonate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-galactonate, the anion of D-galactonic acid." [GOC:mah]
subset: gosubset_prok
synonym: "D-galactonate metabolism" EXACT []
is_a: GO:0019583 ! galactonate metabolic process

[Term]
id: GO:0034193
name: L-galactonate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving L-galactonate, the anion of L-galactonic acid." [GOC:mah]
subset: gosubset_prok
synonym: "L-galactonate metabolism" EXACT []
is_a: GO:0019583 ! galactonate metabolic process

[Term]
id: GO:0034194
name: D-galactonate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-galactonate, the anion of D-galactonic acid." [GOC:ai, GOC:mah]
subset: gosubset_prok
synonym: "D-galactonate breakdown" EXACT []
synonym: "D-galactonate catabolism" EXACT []
synonym: "D-galactonate degradation" EXACT []
xref: MetaCyc:GALACTCAT-PWY
is_a: GO:0019584 ! galactonate catabolic process
is_a: GO:0034192 ! D-galactonate metabolic process

[Term]
id: GO:0034195
name: L-galactonate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-galactonate, the anion of L-galactonic acid." [GOC:ai, GOC:mah]
subset: gosubset_prok
synonym: "L-galactonate breakdown" EXACT []
synonym: "L-galactonate catabolism" EXACT []
synonym: "L-galactonate degradation" EXACT []
xref: MetaCyc:GALACTCAT-PWY
is_a: GO:0019584 ! galactonate catabolic process
is_a: GO:0034193 ! L-galactonate metabolic process

[Term]
id: GO:0034196
name: acylglycerol transport
namespace: biological_process
def: "The directed movement of an acylglycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An acylglycerol is any mono-, di- or triester of glycerol with (one or more) fatty acids." [GOC:BHF, GOC:rl]
synonym: "glyceride transport" EXACT []
is_a: GO:0006869 ! lipid transport

[Term]
id: GO:0034197
name: triglyceride transport
namespace: biological_process
def: "The directed movement of triglyceride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins." [GOC:BHF, GOC:rl]
synonym: "triacylglycerol transport" EXACT []
is_a: GO:0034196 ! acylglycerol transport

[Term]
id: GO:0034198
name: cellular response to amino acid starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids." [GOC:ecd]
is_a: GO:0009267 ! cellular response to starvation

[Term]
id: GO:0034199
name: activation of protein kinase A activity
namespace: biological_process
def: "Any process that initiates the activity of the inactive enzyme protein kinase A." [GOC:pde]
synonym: "protein kinase A activation" EXACT []
xref: Reactome:REACT_100304 "PKA activation, Rattus norvegicus"
xref: Reactome:REACT_101178 "PKA activation, Mus musculus"
xref: Reactome:REACT_101886 "PKA activation, Sus scrofa"
xref: Reactome:REACT_103354 "PKA activation, Mycobacterium tuberculosis"
xref: Reactome:REACT_104223 "PKA activation, Canis familiaris"
xref: Reactome:REACT_109493 "PKA activation, Taeniopygia guttata"
xref: Reactome:REACT_111951 "PKA activation, Plasmodium falciparum"
xref: Reactome:REACT_15530 "PKA activation, Homo sapiens"
xref: Reactome:REACT_30604 "PKA activation, Xenopus tropicalis"
xref: Reactome:REACT_31997 "PKA activation, Danio rerio"
xref: Reactome:REACT_32571 "PKA activation, Schizosaccharomyces pombe"
xref: Reactome:REACT_33986 "PKA activation, Saccharomyces cerevisiae"
xref: Reactome:REACT_43906 "PKA activation, Gallus gallus"
xref: Reactome:REACT_90637 "PKA activation, Bos taurus"
xref: Reactome:REACT_92035 "PKA activation, Caenorhabditis elegans"
xref: Reactome:REACT_95723 "PKA activation, Drosophila melanogaster"
xref: Reactome:REACT_97216 "PKA activation, Dictyostelium discoideum"
is_a: GO:0032147 ! activation of protein kinase activity

[Term]
id: GO:0034200
name: D,D-heptose 1,7-bisphosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-beta-D-heptose 1,7-bisphosphate + H2O = D-beta-D-heptose 1-phosphate + phosphate." [MetaCyc:RXN0-4361, PMID:11279237]
xref: MetaCyc:RXN0-4361
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0034201
name: response to oleic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oleic acid stimulus." [CHEBI:16196, GOC:lp]
synonym: "response to oleate" EXACT [GOC:mah]
is_a: GO:0070542 ! response to fatty acid

[Term]
id: GO:0034202
name: glycolipid-translocating activity
namespace: molecular_function
def: "Catalysis of the movement of glycolipids from one membrane face to the other (glycolipid 'flippase' activity)." [GOC:krc, PMID:11807558]
synonym: "flippase activity" BROAD []
xref: Reactome:REACT_22198 "Flipping of the N-glycan precursor into the ER lumen, Saccharomyces cerevisiae"
xref: Reactome:REACT_22262 "Flipping of the N-glycan precursor to inside the ER, Homo sapiens"
is_a: GO:0017089 ! glycolipid transporter activity
relationship: part_of GO:0034203 ! glycolipid translocation

[Term]
id: GO:0034203
name: glycolipid translocation
namespace: biological_process
def: "The translocation, or flipping, of glycolipid molecules from one monolayer of a membrane bilayer to the opposite monolayer." [GOC:go_curators, PMID:11807558]
subset: gosubset_prok
synonym: "flippase" RELATED []
synonym: "scramblase" RELATED []
is_a: GO:0034204 ! lipid translocation
is_a: GO:0046836 ! glycolipid transport

[Term]
id: GO:0034204
name: lipid translocation
namespace: biological_process
def: "The translocation, or flipping, of lipid molecules from one monolayer of a membrane bilayer to the opposite monolayer." [GOC:mah]
is_a: GO:0006869 ! lipid transport
is_a: GO:0097035 ! regulation of membrane lipid distribution

[Term]
id: GO:0034205
name: beta-amyloid formation
namespace: biological_process
def: "The generation of beta-amyloid by cleavage of the amyloid precursor protein (APP)." [GOC:mah]
comment: Note that this term does not fall under the general GO definition for biosynthetic processes, which is 'The chemical reactions and pathways resulting in the formation of... ', because beta-amyloid can only be formed by the proteolysis of a larger molecule (see term definition). The word 'formation' is therefore used in place of biosynthesis. Also, note that this term refers to the production of the beta-amyloid polypeptide from the amyloid precursor protein (APP), and should be used to annotate e.g. secretases that cleave APP to form beta-amyloid. To annotate gene products involved in the formation of amyloid fibrils, please consider 'amyloid fibril formation' (GO:1990000).
synonym: "beta-amyloid polypeptide formation from amyloid precursor protein" EXACT []
synonym: "beta-amyloid polypeptide formation from APP" EXACT []
is_a: GO:0042987 ! amyloid precursor protein catabolic process
is_a: GO:0050435 ! beta-amyloid metabolic process

[Term]
id: GO:0034206
name: enhanceosome
namespace: cellular_component
def: "A protein-DNA complex formed by the association of a distinct set of general and specific transcription factors with a region of enhancer DNA. The cooperative assembly of an enhanceosome confers specificity of transcriptional regulation." [PMID:11250145, PMID:17574024]
xref: Wikipedia:Enhanceosome
is_a: GO:0032993 ! protein-DNA complex

[Term]
id: GO:0034207
name: steroid acetylation
namespace: biological_process
def: "The addition of an acetyl group to a steroid molecule. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:mah]
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:0030258 ! lipid modification

[Term]
id: GO:0034208
name: steroid deacetylation
namespace: biological_process
def: "The removal of an acetyl group from a steroid molecule. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:mah]
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:0030258 ! lipid modification

[Term]
id: GO:0034209
name: sterol acetylation
namespace: biological_process
def: "The addition of an acetyl group to a sterol molecule. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:rb, PMID:18034159]
is_a: GO:0016125 ! sterol metabolic process
is_a: GO:0034207 ! steroid acetylation

[Term]
id: GO:0034210
name: sterol deacetylation
namespace: biological_process
def: "The removal of an acetyl group from a sterol molecule. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:rb, PMID:18034159]
is_a: GO:0016125 ! sterol metabolic process
is_a: GO:0034208 ! steroid deacetylation

[Term]
id: GO:0034211
name: GTP-dependent protein kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate, dependent on the presence of GTP." [GOC:ecd, PMID:17200152]
xref: EC:2.7.11.-
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0034212
name: peptide N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the acetylation of an amino acid residue of a peptide or protein, according to the reaction: acetyl-CoA + peptide = CoA + N-acetylpeptide." [GOC:mah]
subset: gosubset_prok
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0034213
name: quinolinate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid." [GOC:mah]
synonym: "quinolinate breakdown" EXACT []
synonym: "quinolinate catabolism" EXACT []
synonym: "quinolinate degradation" EXACT []
is_a: GO:0043649 ! dicarboxylic acid catabolic process
is_a: GO:0046874 ! quinolinate metabolic process
is_a: GO:0072526 ! pyridine-containing compound catabolic process

[Term]
id: GO:0034214
name: protein hexamerization
namespace: biological_process
def: "The formation of a protein hexamer, a macromolecular structure consisting of six noncovalently associated identical or nonidentical subunits." [GOC:ecd]
subset: gosubset_prok
synonym: "protein hexamer assembly" EXACT []
synonym: "protein hexamer biosynthesis" EXACT []
synonym: "protein hexamer biosynthetic process" EXACT []
synonym: "protein hexamer formation" EXACT []
is_a: GO:0051259 ! protein oligomerization

[Term]
id: GO:0034215
name: thiamine:proton symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: thiamine(out) + H+(out) = thiamine(in) + H+(in)." [GOC:mah]
synonym: "thiamin:hydrogen symporter activity" EXACT [GOC:curators]
synonym: "thiamin:proton symporter activity" EXACT []
synonym: "thiamine:hydrogen symporter activity" EXACT []
is_a: GO:0015295 ! solute:proton symporter activity
is_a: GO:0015403 ! thiamine uptake transmembrane transporter activity

[Term]
id: GO:0034216
name: high-affinity thiamine:proton symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: thiamine(out) + H+(out) = thiamine(in) + H+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mah]
synonym: "high affinity thiamin:hydrogen symporter activity" EXACT []
synonym: "high-affinity thiamin:hydrogen symporter activity" EXACT [GOC:curators]
synonym: "high-affinity thiamin:proton symporter activity" EXACT []
synonym: "high-affinity thiamine:hydrogen symporter activity" EXACT []
is_a: GO:0034215 ! thiamine:proton symporter activity

[Term]
id: GO:0034217
name: ascospore wall chitin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ascospore wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of ascospores." [GOC:mah, GOC:vw]
synonym: "ascospore wall chitin anabolism" EXACT []
synonym: "ascospore wall chitin biosynthesis" EXACT []
synonym: "ascospore wall chitin formation" EXACT []
synonym: "ascospore wall chitin synthesis" EXACT []
is_a: GO:0034218 ! ascospore wall chitin metabolic process
is_a: GO:0034221 ! fungal-type cell wall chitin biosynthetic process
is_a: GO:0044106 ! cellular amine metabolic process
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0070591 ! ascospore wall biogenesis

[Term]
id: GO:0034218
name: ascospore wall chitin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ascospore wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of ascospores." [GOC:mah, GOC:vw]
synonym: "ascospore wall chitin metabolism" EXACT []
is_a: GO:0006037 ! cell wall chitin metabolic process
is_a: GO:0044264 ! cellular polysaccharide metabolic process
is_a: GO:0044723 ! single-organism carbohydrate metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0071966 ! fungal-type cell wall polysaccharide metabolic process

[Term]
id: GO:0034219
name: carbohydrate transmembrane transport
namespace: biological_process
def: "The process in which a carbohydrate is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "carbohydrate membrane transport" EXACT []
synonym: "transmembrane carbohydrate transport" EXACT [GOC:dph, GOC:tb]
is_a: GO:0008643 ! carbohydrate transport
is_a: GO:0055085 ! transmembrane transport

[Term]
id: GO:0034220
name: ion transmembrane transport
namespace: biological_process
def: "A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "ion membrane transport" EXACT []
synonym: "transmembrane ion transport" EXACT [GOC:dph, GOC:tb]
xref: Reactome:REACT_100497 "Ion channel transport, Rattus norvegicus"
xref: Reactome:REACT_101721 "Ion transport by P-type ATPases, Canis familiaris"
xref: Reactome:REACT_103924 "Ion transport by P-type ATPases, Taeniopygia guttata"
xref: Reactome:REACT_107347 "Ion channel transport, Caenorhabditis elegans"
xref: Reactome:REACT_108844 "Ion transport by P-type ATPases, Drosophila melanogaster"
xref: Reactome:REACT_109050 "Ion channel transport, Gallus gallus"
xref: Reactome:REACT_25149 "Ion transport by P-type ATPases, Homo sapiens"
xref: Reactome:REACT_25300 "Ion channel transport, Homo sapiens"
xref: Reactome:REACT_25387 "Ligand-gated ion channel transport, Homo sapiens"
xref: Reactome:REACT_28672 "Ion transport by P-type ATPases, Arabidopsis thaliana"
xref: Reactome:REACT_30601 "Ion channel transport, Danio rerio"
xref: Reactome:REACT_31166 "Ion channel transport, Sus scrofa"
xref: Reactome:REACT_32763 "Ion channel transport, Plasmodium falciparum"
xref: Reactome:REACT_33389 "Ion channel transport, Mycobacterium tuberculosis"
xref: Reactome:REACT_34584 "Ion channel transport, Oryza sativa"
xref: Reactome:REACT_77153 "Ion channel transport, Arabidopsis thaliana"
xref: Reactome:REACT_77267 "Ion channel transport, Taeniopygia guttata"
xref: Reactome:REACT_78982 "Ion transport by P-type ATPases, Bos taurus"
xref: Reactome:REACT_79679 "Ion transport by P-type ATPases, Xenopus tropicalis"
xref: Reactome:REACT_81685 "Ion channel transport, Bos taurus"
xref: Reactome:REACT_82102 "Ion channel transport, Canis familiaris"
xref: Reactome:REACT_89671 "Ion channel transport, Xenopus tropicalis"
xref: Reactome:REACT_89674 "Ion transport by P-type ATPases, Caenorhabditis elegans"
xref: Reactome:REACT_89758 "Ion transport by P-type ATPases, Sus scrofa"
xref: Reactome:REACT_89890 "Ion transport by P-type ATPases, Oryza sativa"
xref: Reactome:REACT_92146 "Ion transport by P-type ATPases, Mus musculus"
xref: Reactome:REACT_93475 "Ion transport by P-type ATPases, Rattus norvegicus"
xref: Reactome:REACT_94109 "Ion channel transport, Mus musculus"
xref: Reactome:REACT_94939 "Ion transport by P-type ATPases, Mycobacterium tuberculosis"
xref: Reactome:REACT_94986 "Ion transport by P-type ATPases, Plasmodium falciparum"
xref: Reactome:REACT_97506 "Ion transport by P-type ATPases, Danio rerio"
xref: Reactome:REACT_97619 "Ion channel transport, Drosophila melanogaster"
xref: Reactome:REACT_98518 "Ion transport by P-type ATPases, Gallus gallus"
is_a: GO:0006811 ! ion transport
is_a: GO:0055085 ! transmembrane transport

[Term]
id: GO:0034221
name: fungal-type cell wall chitin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cell wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of fungal cells." [GOC:mah]
synonym: "fungal-type cell wall chitin anabolism" EXACT []
synonym: "fungal-type cell wall chitin biosynthesis" EXACT []
synonym: "fungal-type cell wall chitin formation" EXACT []
synonym: "fungal-type cell wall chitin synthesis" EXACT []
is_a: GO:0006038 ! cell wall chitin biosynthetic process
is_a: GO:0051278 ! fungal-type cell wall polysaccharide biosynthetic process

[Term]
id: GO:0034222
name: regulation of cell wall chitin metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving chitin in a cell wall." [GOC:mah]
synonym: "regulation of cell wall chitin metabolism" EXACT []
is_a: GO:0010981 ! regulation of cell wall macromolecule metabolic process
is_a: GO:0032882 ! regulation of chitin metabolic process
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006037 ! cell wall chitin metabolic process
relationship: regulates GO:0006037 ! cell wall chitin metabolic process

[Term]
id: GO:0034223
name: regulation of ascospore wall chitin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ascospore wall chitin." [GOC:mah]
synonym: "regulation of ascospore wall chitin anabolism" EXACT []
synonym: "regulation of ascospore wall chitin biosynthesis" EXACT []
synonym: "regulation of ascospore wall chitin formation" EXACT []
synonym: "regulation of ascospore wall chitin synthesis" EXACT []
is_a: GO:0032884 ! regulation of cell wall chitin biosynthetic process
is_a: GO:0032995 ! regulation of fungal-type cell wall biogenesis
is_a: GO:0033238 ! regulation of cellular amine metabolic process
is_a: GO:0034307 ! regulation of ascospore formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034217 ! ascospore wall chitin biosynthetic process
relationship: regulates GO:0034217 ! ascospore wall chitin biosynthetic process

[Term]
id: GO:0034224
name: cellular response to zinc ion starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of zinc ions." [GOC:mah]
synonym: "cellular response to zinc ion limitation" EXACT []
synonym: "cellular response to zinc starvation" EXACT []
is_a: GO:0009267 ! cellular response to starvation

[Term]
id: GO:0034225
name: regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation
namespace: biological_process
def: "Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is deprived of zinc ions." [GOC:mah]
synonym: "regulation of transcription from RNA polymerase II promoter in response to zinc deficiency" EXACT []
synonym: "regulation of transcription from RNA polymerase II promoter in response to zinc ion limitation" EXACT []
is_a: GO:0034224 ! cellular response to zinc ion starvation
is_a: GO:0043618 ! regulation of transcription from RNA polymerase II promoter in response to stress

[Term]
id: GO:0034226
name: lysine import
namespace: biological_process
def: "The directed movement of lysine, 2,6-diaminohexanoic acid, into a cell or organelle." [GOC:jl, GOC:mah]
synonym: "L-lysine import" NARROW []
synonym: "lysine uptake" EXACT []
is_a: GO:0015819 ! lysine transport
is_a: GO:0043090 ! amino acid import

[Term]
id: GO:0034227
name: tRNA thio-modification
namespace: biological_process
def: "The addition a sulfur atom to a nucleotide in a tRNA molecule." [GOC:mcc, PMID:12549933, PMID:14722066]
subset: gosubset_prok
synonym: "tRNA sulfurtransferase activity" RELATED [GOC:mah]
synonym: "tRNA thiolation" EXACT [PMID:24774365]
is_a: GO:0006400 ! tRNA modification

[Term]
id: GO:0034228
name: ethanolamine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of ethanolamine from one side of the membrane to the other. Ethanolamine (2-aminoethanol, monoethanolamine) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids, such as phosphatidylethanolamine." [GOC:rn, PMID:3514579]
subset: gosubset_prok
synonym: "2-aminoethanol transmembrane transporter activity" EXACT []
synonym: "ethanolamine permease activity" EXACT []
synonym: "monoethanolamine transmembrane transporter activity" EXACT []
xref: RHEA:32750
is_a: GO:0005275 ! amine transmembrane transporter activity
is_a: GO:0008519 ! ammonium transmembrane transporter activity
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:0015665 ! alcohol transmembrane transporter activity
relationship: part_of GO:0034229 ! ethanolamine transport

[Term]
id: GO:0034229
name: ethanolamine transport
namespace: biological_process
def: "The directed movement of ethanolamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ethanolamine (2-aminoethanol, monoethanolamine) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids, such as phosphatidylethanolamine." [GOC:rn, PMID:3514579]
synonym: "2-aminoethanol transport" EXACT []
synonym: "monoethanolamine transport" EXACT []
is_a: GO:0015695 ! organic cation transport
is_a: GO:0015696 ! ammonium transport
is_a: GO:0015837 ! amine transport
is_a: GO:0015850 ! organic hydroxy compound transport

[Term]
id: GO:0034230
name: enkephalin processing
namespace: biological_process
def: "The formation of mature enkephalin, a pentapeptide hormone involved in regulating pain and nociception in the body by proteolytic processing of enkephalin propeptide." [GOC:BHF, GOC:mah, GOC:rl, PMID:8262946]
synonym: "enkephalin formation" EXACT []
synonym: "peptide enkephalin formation" EXACT []
synonym: "peptide enkephalin processing" EXACT []
is_a: GO:0016486 ! peptide hormone processing

[Term]
id: GO:0034231
name: islet amyloid polypeptide processing
namespace: biological_process
def: "The formation of mature islet amyloid polypeptide (IAPP) by posttranslational processing of pro-islet amyloid polypeptide (pro-IAPP)." [GOC:BHF, GOC:rl, PMID:15983213, PMID:8262946]
synonym: "IAPP formation" EXACT []
synonym: "IAPP processing" EXACT []
synonym: "islet amyloid peptide formation" EXACT []
synonym: "islet amyloid peptide processing" EXACT []
synonym: "islet amyloid polypeptide formation" RELATED []
is_a: GO:0016486 ! peptide hormone processing

[Term]
id: GO:0034232
name: ascospore wall chitin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ascospore wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of ascospores." [GOC:mah]
synonym: "ascospore wall chitin breakdown" EXACT []
synonym: "ascospore wall chitin catabolism" EXACT []
synonym: "ascospore wall chitin degradation" EXACT []
is_a: GO:0006039 ! cell wall chitin catabolic process
is_a: GO:0034218 ! ascospore wall chitin metabolic process
is_a: GO:0044247 ! cellular polysaccharide catabolic process
is_a: GO:0044724 ! single-organism carbohydrate catabolic process
is_a: GO:0071854 ! cell wall macromolecule catabolic process involved in fungal-type cell wall disassembly

[Term]
id: GO:0034233
name: regulation of cell wall chitin catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cell wall chitin." [GOC:mah]
synonym: "regulation of cell wall chitin breakdown" EXACT []
synonym: "regulation of cell wall chitin catabolism" EXACT []
synonym: "regulation of cell wall chitin degradation" EXACT []
is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:0034222 ! regulation of cell wall chitin metabolic process
is_a: GO:0043470 ! regulation of carbohydrate catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006039 ! cell wall chitin catabolic process
relationship: regulates GO:0006039 ! cell wall chitin catabolic process

[Term]
id: GO:0034234
name: regulation of ascospore wall chitin catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of ascospore wall chitin." [GOC:mah]
synonym: "regulation of ascospore wall chitin breakdown" EXACT []
synonym: "regulation of ascospore wall chitin catabolism" EXACT []
synonym: "regulation of ascospore wall chitin degradation" EXACT []
is_a: GO:0034233 ! regulation of cell wall chitin catabolic process
is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process
is_a: GO:0060237 ! regulation of fungal-type cell wall organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034232 ! ascospore wall chitin catabolic process
relationship: regulates GO:0034232 ! ascospore wall chitin catabolic process

[Term]
id: GO:0034235
name: GPI anchor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any glycosylphosphatidylinositol anchor. GPI anchors serve to attach membrane proteins to the lipid bilayer of cell membranes." [GOC:vw]
comment: Note that this term should be used to annotate gene products that interact non-covalently with GPI anchors, and not proteins that have GPI anchors covalently attached.
synonym: "glycosylphosphatidylinositol binding" EXACT []
is_a: GO:0035091 ! phosphatidylinositol binding
is_a: GO:0051861 ! glycolipid binding

[Term]
id: GO:0034236
name: protein kinase A catalytic subunit binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with one or both of the catalytic subunits of protein kinase A." [GOC:mah]
synonym: "PKA catalytic subunit binding" EXACT []
is_a: GO:0019901 ! protein kinase binding
is_a: GO:0051018 ! protein kinase A binding

[Term]
id: GO:0034237
name: protein kinase A regulatory subunit binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with one or both of the regulatory subunits of protein kinase A." [GOC:mah]
synonym: "PKA regulatory subunit binding" EXACT []
synonym: "protein kinase A anchoring activity" RELATED []
is_a: GO:0051018 ! protein kinase A binding

[Term]
id: GO:0034238
name: macrophage fusion
namespace: biological_process
def: "The binding and fusion of a macrophage to one or more other cells to form a multinucleated cell." [GOC:sl]
is_a: GO:0000768 ! syncytium formation by plasma membrane fusion

[Term]
id: GO:0034239
name: regulation of macrophage fusion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of macrophage fusion." [GOC:mah]
is_a: GO:0060142 ! regulation of syncytium formation by plasma membrane fusion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034238 ! macrophage fusion
relationship: regulates GO:0034238 ! macrophage fusion

[Term]
id: GO:0034240
name: negative regulation of macrophage fusion
namespace: biological_process
def: "Any process that stops, prevents, or decreases the frequency, rate or extent of macrophage fusion." [GOC:mah]
is_a: GO:0034239 ! regulation of macrophage fusion
is_a: GO:0034242 ! negative regulation of syncytium formation by plasma membrane fusion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034238 ! macrophage fusion
relationship: negatively_regulates GO:0034238 ! macrophage fusion

[Term]
id: GO:0034241
name: positive regulation of macrophage fusion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of macrophage fusion." [GOC:mah]
is_a: GO:0034239 ! regulation of macrophage fusion
is_a: GO:0060143 ! positive regulation of syncytium formation by plasma membrane fusion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034238 ! macrophage fusion
relationship: positively_regulates GO:0034238 ! macrophage fusion

[Term]
id: GO:0034242
name: negative regulation of syncytium formation by plasma membrane fusion
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:mah]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:0060142 ! regulation of syncytium formation by plasma membrane fusion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000768 ! syncytium formation by plasma membrane fusion
relationship: negatively_regulates GO:0000768 ! syncytium formation by plasma membrane fusion

[Term]
id: GO:0034243
name: regulation of transcription elongation from RNA polymerase II promoter
namespace: biological_process
alt_id: GO:0090039
def: "Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH]
synonym: "regulation of gene-specific transcription elongation from RNA polymerase II promoter" RELATED []
synonym: "regulation of RNA elongation from RNA polymerase II promoter" EXACT []
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0032784 ! regulation of DNA-templated transcription, elongation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006368 ! transcription elongation from RNA polymerase II promoter
relationship: regulates GO:0006368 ! transcription elongation from RNA polymerase II promoter

[Term]
id: GO:0034244
name: negative regulation of transcription elongation from RNA polymerase II promoter
namespace: biological_process
alt_id: GO:0090041
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH]
synonym: "negative regulation of gene-specific transcription elongation from RNA polymerase II promoter" RELATED []
synonym: "negative regulation of RNA elongation from RNA polymerase II promoter" EXACT []
is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
is_a: GO:0032785 ! negative regulation of DNA-templated transcription, elongation
is_a: GO:0034243 ! regulation of transcription elongation from RNA polymerase II promoter
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006368 ! transcription elongation from RNA polymerase II promoter
relationship: negatively_regulates GO:0006368 ! transcription elongation from RNA polymerase II promoter

[Term]
id: GO:0034245
name: mitochondrial DNA-directed RNA polymerase complex
namespace: cellular_component
def: "A DNA-directed RNA polymerase complex located in the mitochondrion. Mitochondrial RNA polymerase is composed of two subunits, a catalytic core, which resembles the enzymes from bacteriophage T7 and T3, and a specificity factor required for promoter recognition, which is similar to members of the eubacterial sigma factor family. In S. cerevisiae, these are encoded by the nuclear genes RPO41 and MTF1 and the specificity factor, required for promoter recognition and initiation, is not present in the elongating form." [GOC:krc, GOC:mah, PMID:7929382]
synonym: "mitochondrial RNA polymerase complex" BROAD []
synonym: "mitochondrial RNA polymerase holoenzyme complex" EXACT []
is_a: GO:0000428 ! DNA-directed RNA polymerase complex
is_a: GO:0098798 ! mitochondrial protein complex
intersection_of: GO:0000428 ! DNA-directed RNA polymerase complex
intersection_of: part_of GO:0005739 ! mitochondrion
relationship: part_of GO:0005739 ! mitochondrion

[Term]
id: GO:0034246
name: mitochondrial RNA polymerase binding promoter specificity activity
namespace: molecular_function
alt_id: GO:0000998
def: "Interacting selectively and non-covalently with a mitochondrial RNA polymerase to form a holoenzyme complex and also, while present in the holoenzyme, interacting with promoter sequences in order to confer sequence specific recognition of mitochondrial promoter DNA sequence motifs." [GOC:txnOH]
synonym: "mitochondrial polymerase transcription factor activity" EXACT []
synonym: "mitochondrial transcription factor activity" RELATED []
synonym: "mitochondrial transcription initiation factor activity" EXACT []
is_a: GO:0000996 ! core DNA-dependent RNA polymerase binding promoter specificity activity
intersection_of: GO:0003674 ! molecular_function
intersection_of: has_part GO:0001001 ! mitochondrial single-subunit type RNA polymerase binding
intersection_of: has_part GO:0044212 ! transcription regulatory region DNA binding
intersection_of: part_of GO:1903108 ! regulation of transcription from mitochondrial promoter
relationship: has_part GO:0000997 ! mitochondrial RNA polymerase core promoter sequence-specific DNA binding
relationship: has_part GO:0001001 ! mitochondrial single-subunit type RNA polymerase binding
relationship: has_part GO:0044212 ! transcription regulatory region DNA binding
relationship: part_of GO:0006391 ! transcription initiation from mitochondrial promoter
relationship: part_of GO:1903108 ! regulation of transcription from mitochondrial promoter

[Term]
id: GO:0034247
name: snoRNA splicing
namespace: biological_process
def: "The process of removing sections of a primary snoRNA transcript to remove sequences not present in the mature form of the snoRNA and joining the remaining sections to form the mature form of the snoRNA." [GOC:mah]
is_a: GO:0008380 ! RNA splicing
is_a: GO:0043144 ! snoRNA processing

[Term]
id: GO:0034248
name: regulation of cellular amide metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amides." [GOC:mah]
synonym: "regulation of amide metabolism" EXACT []
is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043603 ! cellular amide metabolic process
relationship: regulates GO:0043603 ! cellular amide metabolic process

[Term]
id: GO:0034249
name: negative regulation of cellular amide metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amides." [GOC:mah]
synonym: "negative regulation of amide metabolism" EXACT []
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0034248 ! regulation of cellular amide metabolic process
is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043603 ! cellular amide metabolic process
relationship: negatively_regulates GO:0043603 ! cellular amide metabolic process

[Term]
id: GO:0034250
name: positive regulation of cellular amide metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amides." [GOC:mah]
synonym: "positive regulation of amide metabolism" EXACT []
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0034248 ! regulation of cellular amide metabolic process
is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043603 ! cellular amide metabolic process
relationship: positively_regulates GO:0043603 ! cellular amide metabolic process

[Term]
id: GO:0034251
name: regulation of cellular amide catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides." [GOC:mah]
synonym: "regulation of amide breakdown" EXACT []
synonym: "regulation of amide catabolism" EXACT []
synonym: "regulation of amide degradation" EXACT []
is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:0034248 ! regulation of cellular amide metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043605 ! cellular amide catabolic process
relationship: regulates GO:0043605 ! cellular amide catabolic process

[Term]
id: GO:0034252
name: negative regulation of cellular amide catabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides." [GOC:mah]
synonym: "negative regulation of amide breakdown" EXACT []
synonym: "negative regulation of amide catabolism" EXACT []
synonym: "negative regulation of amide degradation" RELATED []
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:0034249 ! negative regulation of cellular amide metabolic process
is_a: GO:0034251 ! regulation of cellular amide catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043605 ! cellular amide catabolic process
relationship: negatively_regulates GO:0043605 ! cellular amide catabolic process

[Term]
id: GO:0034253
name: positive regulation of cellular amide catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides." [GOC:mah]
synonym: "positive regulation of amide breakdown" EXACT []
synonym: "positive regulation of amide catabolism" EXACT []
synonym: "positive regulation of amide degradation" RELATED []
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:0034250 ! positive regulation of cellular amide metabolic process
is_a: GO:0034251 ! regulation of cellular amide catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043605 ! cellular amide catabolic process
relationship: positively_regulates GO:0043605 ! cellular amide catabolic process

[Term]
id: GO:0034254
name: regulation of urea catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of urea." [GOC:mah]
synonym: "regulation of urea breakdown" EXACT []
synonym: "regulation of urea catabolism" EXACT []
synonym: "regulation of urea degradation" EXACT []
is_a: GO:0034251 ! regulation of cellular amide catabolic process
is_a: GO:0034255 ! regulation of urea metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043419 ! urea catabolic process
relationship: regulates GO:0043419 ! urea catabolic process

[Term]
id: GO:0034255
name: regulation of urea metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving urea." [GOC:mah]
synonym: "regulation of urea metabolism" EXACT []
is_a: GO:0034248 ! regulation of cellular amide metabolic process
is_a: GO:1903314 ! regulation of nitrogen cycle metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019627 ! urea metabolic process
relationship: regulates GO:0019627 ! urea metabolic process

[Term]
id: GO:0034256
name: chlorophyll(ide) b reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 71-hydroxychlorophyll(ide) a + NAD(P)+ = chlorophyll(ide) b + NAD(P)H + H+." [EC:1.1.1.294, MetaCyc:RXN-7678]
synonym: "Chl b reductase activity" EXACT []
synonym: "chlorophyll b reductase activity" EXACT []
synonym: "chlorophyllide b reductase activity" EXACT []
xref: EC:1.1.1.294
xref: MetaCyc:RXN-7678
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0034257
name: nicotinamide riboside transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of nicotinamide riboside, which is a pyridine-3-carboxamide covalently bonded to a ribose sugar, from one side of a membrane to the other." [GOC:se]
xref: RHEA:33166
is_a: GO:0005337 ! nucleoside transmembrane transporter activity
relationship: part_of GO:0034258 ! nicotinamide riboside transport

[Term]
id: GO:0034258
name: nicotinamide riboside transport
namespace: biological_process
def: "The directed movement of a nicotinamide riboside, which is a pyridine-3-carboxamide covalently bonded to a ribose sugar, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:se]
is_a: GO:0015858 ! nucleoside transport

[Term]
id: GO:0034260
name: negative regulation of GTPase activity
namespace: biological_process
alt_id: GO:0034259
alt_id: GO:0034261
alt_id: GO:1902264
alt_id: GO:1902881
def: "Any process that stops or reduces the rate of GTP hydrolysis by a GTPase." [GO_REF:0000058, GOC:mah, GOC:rb, GOC:TermGenie, PMID:16143306, PMID:24335649]
comment: An example of this is P2xA in Dictyostelium (UniProt symbol Q86JM7) in PMID:24335649.
synonym: "down regulation of GTPase activity" EXACT []
synonym: "down regulation of Rab GTPase activity" NARROW [GOC:pf]
synonym: "down regulation of Ras GTPase activity" NARROW []
synonym: "down regulation of regulation of Ran GTPase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of Rho GTPase activity" NARROW []
synonym: "down-regulation of GTPase activity" EXACT []
synonym: "down-regulation of Rab GTPase activity" NARROW [GOC:pf]
synonym: "down-regulation of Ras GTPase activity" NARROW []
synonym: "down-regulation of regulation of Ran GTPase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of Rho GTPase activity" NARROW []
synonym: "downregulation of GTPase activity" EXACT []
synonym: "downregulation of Rab GTPase activity" NARROW [GOC:pf]
synonym: "downregulation of Ras GTPase activity" NARROW []
synonym: "downregulation of regulation of Ran GTPase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of Rho GTPase activity" NARROW []
synonym: "inhibition of GTPase activity" NARROW []
synonym: "inhibition of Rab GTPase activity" NARROW [GOC:pf]
synonym: "inhibition of Ras GTPase activity" NARROW []
synonym: "inhibition of regulation of Ran GTPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of Rho GTPase activity" NARROW []
synonym: "negative regulation of guanosinetriphosphatase activity" EXACT []
synonym: "negative regulation of Rab GTPase activity" NARROW []
synonym: "negative regulation of Ran GTPase activity" NARROW []
synonym: "negative regulation of Ras GTPase activity" NARROW []
synonym: "negative regulation of Rho GTPase activity" NARROW []
is_a: GO:0043087 ! regulation of GTPase activity
is_a: GO:0051346 ! negative regulation of hydrolase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003924 ! GTPase activity
relationship: negatively_regulates GO:0003924 ! GTPase activity

[Term]
id: GO:0034263
name: autophagy in response to ER overload
namespace: biological_process
def: "The process in which cells digest parts of their own cytoplasm in response to the accumulation of misfolded proteins in the endoplasmic reticulum." [GOC:mah]
synonym: "autophagy in response to endoplasmic reticulum overload" EXACT []
synonym: "autophagy in response to ER stress" EXACT []
is_a: GO:0006914 ! autophagy
is_a: GO:0006983 ! ER overload response
is_a: GO:0044712 ! single-organism catabolic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0034264
name: isopentenyl adenine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the cytokinin 6-isopentenyladenine." [GOC:mah, PMID:18216168]
synonym: "isopentenyl adenine metabolism" EXACT []
synonym: "isopentenyladenine metabolic process" EXACT []
is_a: GO:0009690 ! cytokinin metabolic process
is_a: GO:0072521 ! purine-containing compound metabolic process

[Term]
id: GO:0034265
name: isopentenyl adenine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the cytokinin 6-isopentenyladenine." [GOC:mah, PMID:18216168]
subset: gosubset_prok
synonym: "isopentenyl adenine anabolism" EXACT []
synonym: "isopentenyl adenine biosynthesis" EXACT []
synonym: "isopentenyl adenine formation" EXACT []
synonym: "isopentenyl adenine synthesis" EXACT []
synonym: "isopentenyladenine biosynthetic process" EXACT []
is_a: GO:0009691 ! cytokinin biosynthetic process
is_a: GO:0034264 ! isopentenyl adenine metabolic process
is_a: GO:0072522 ! purine-containing compound biosynthetic process

[Term]
id: GO:0034266
name: isopentenyl adenine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the cytokinin 6-isopentenyladenine." [GOC:mah, PMID:18216168]
subset: gosubset_prok
synonym: "isopentenyl adenine breakdown" EXACT []
synonym: "isopentenyl adenine catabolism" EXACT []
synonym: "isopentenyl adenine degradation" EXACT []
synonym: "isopentenyladenine catabolic process" EXACT []
is_a: GO:0009823 ! cytokinin catabolic process
is_a: GO:0034264 ! isopentenyl adenine metabolic process
is_a: GO:0072523 ! purine-containing compound catabolic process

[Term]
id: GO:0034267
name: discadenine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving discadenine, (2S)-2-amino-4-{6-[(3-methylbut-2-en-1-yl)amino]-3H-purin-3-yl}butanoic acid." [CHEBI:15955, GOC:mah]
synonym: "discadenine metabolism" EXACT []
is_a: GO:0009690 ! cytokinin metabolic process
is_a: GO:0072521 ! purine-containing compound metabolic process
is_a: GO:1901605 ! alpha-amino acid metabolic process

[Term]
id: GO:0034268
name: discadenine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of discadenine, (2S)-2-amino-4-{6-[(3-methylbut-2-en-1-yl)amino]-3H-purin-3-yl}butanoic acid." [CHEBI:15955, GOC:mah]
synonym: "discadenine anabolism" EXACT []
synonym: "discadenine biosynthesis" EXACT []
synonym: "discadenine formation" EXACT []
synonym: "discadenine synthesis" EXACT []
is_a: GO:0009691 ! cytokinin biosynthetic process
is_a: GO:0034267 ! discadenine metabolic process
is_a: GO:0072522 ! purine-containing compound biosynthetic process
is_a: GO:1901607 ! alpha-amino acid biosynthetic process

[Term]
id: GO:0034269
name: discadenine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of discadenine, (2S)-2-amino-4-{6-[(3-methylbut-2-en-1-yl)amino]-3H-purin-3-yl}butanoic acid." [CHEBI:15955, GOC:mah]
synonym: "discadenine breakdown" EXACT []
synonym: "discadenine catabolism" EXACT []
synonym: "discadenine degradation" EXACT []
is_a: GO:0009823 ! cytokinin catabolic process
is_a: GO:0034267 ! discadenine metabolic process
is_a: GO:0072523 ! purine-containing compound catabolic process
is_a: GO:1901606 ! alpha-amino acid catabolic process

[Term]
id: GO:0034270
name: CVT complex
namespace: cellular_component
def: "A protein complex that is involved in the CVT pathway. In budding yeast, the CVT complex consists of multimers of preApe1p." [GOC:rb, PMID:15659643]
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0034271
name: phosphatidylinositol 3-kinase complex, class III, type I
namespace: cellular_component
def: "A class III phosphatidylinositol 3-kinase complex that is involved in autophagy. In budding yeast, this complex consists of Vps30p, Vps34p, Apg14p and Vps15p." [GOC:ha, GOC:rb, PMID:11157979, PMID:16421251]
comment: Note that this term should not be confused with '1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex; GO:0005943' or '1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex ; GO:0005944'.
synonym: "phosphatidylinositol 3-kinase complex I" RELATED []
synonym: "PtdIns-3-kinase complex I" RELATED []
is_a: GO:0035032 ! phosphatidylinositol 3-kinase complex, class III

[Term]
id: GO:0034272
name: phosphatidylinositol 3-kinase complex, class III, type II
namespace: cellular_component
def: "A class III phosphatidylinositol 3-kinase complex that is involved in vacuolar protein sorting (VPS) via endosomes. In budding yeast, this complex consists of Vps30p, Vps34p, Vps38 and Vps15p." [GOC:ha, GOC:rb, PMID:11157979, PMID:16421251]
comment: Note that this term should not be confused with '1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex; GO:0005943' or '1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex ; GO:0005944'.
synonym: "phosphatidylinositol 3-kinase complex II" RELATED []
synonym: "PtdIns-3-kinase complex II" RELATED []
is_a: GO:0035032 ! phosphatidylinositol 3-kinase complex, class III

[Term]
id: GO:0034274
name: Atg12-Atg5-Atg16 complex
namespace: cellular_component
def: "A protein complex required for the expansion of the autophagosomal membrane. In budding yeast, this complex consists of Atg12p, Atg5p and Atg16p." [GOC:rb, PMID:17986448]
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0034275
name: kynurenic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving kynurenic acid, 4-hydroxyquinoline-2-carboxylic acid." [CHEBI:18344, GOC:mah]
synonym: "4-hydroxyquinoline-2-carboxylic acid metabolic process" EXACT []
synonym: "kynurenic acid metabolism" EXACT []
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process

[Term]
id: GO:0034276
name: kynurenic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of kynurenic acid, 4-hydroxyquinoline-2-carboxylic acid." [CHEBI:18344, GOC:mah]
synonym: "4-hydroxyquinoline-2-carboxylic acid biosynthetic process" EXACT []
synonym: "kynurenic acid anabolism" EXACT []
synonym: "kynurenic acid biosynthesis" EXACT []
synonym: "kynurenic acid formation" RELATED []
synonym: "kynurenic acid synthesis" EXACT []
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0034275 ! kynurenic acid metabolic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process

[Term]
id: GO:0034277
name: ent-cassa-12,15-diene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ent-copalyl diphosphate = ent-cassa-12,15-diene + diphosphate." [EC:4.2.3.28, RHEA:25535]
synonym: "ent-copalyl-diphosphate diphosphate-lyase (ent-cassa-12,15-diene-forming) activity" EXACT systematic_synonym [EC:4.2.3.28, KEGG:R09119]
xref: EC:4.2.3.28
xref: KEGG:R09119
xref: MetaCyc:RXN-4881
xref: RHEA:25535
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0034278
name: stemar-13-ene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 9-alpha-copalyl diphosphate = stemar-13-ene + diphosphate." [MetaCyc:RXN-4882, RHEA:25555]
synonym: "9alpha-copalyl-diphosphate diphosphate-lyase (stemar-13-ene-forming) activity" EXACT systematic_synonym [KEGG:R09115]
xref: EC:4.2.3.33
xref: KEGG:R09115
xref: MetaCyc:RXN-4882
xref: RHEA:25555
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0034279
name: syn-pimara-7,15-diene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 9-alpha-copalyl diphosphate = 9-beta-pimara-7,15-diene + diphosphate." [MetaCyc:RXN-4883, RHEA:25563]
synonym: "9alpha-copalyl-diphosphate diphosphate-lyase (9beta-pimara-7,15-diene-forming) activity" EXACT systematic_synonym [KEGG:R09117]
xref: EC:4.2.3.35
xref: KEGG:R09117
xref: MetaCyc:RXN-4883
xref: RHEA:25563
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0034280
name: ent-sandaracopimaradiene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ent-copalyl diphosphate = ent-sandaracopimara-8(14),15-diene + diphosphate." [MetaCyc:RXN-4884, RHEA:25539]
synonym: "ent-copalyl-diphosphate diphosphate-lyase [ent-sandaracopimara-8(14),15-diene-forming] activity" EXACT systematic_synonym [KEGG:R09120]
synonym: "ent-pimaradiene synthase activity" BROAD []
xref: EC:4.2.3.29
xref: KEGG:R09120
xref: MetaCyc:RXN-4884
xref: RHEA:25539
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0034281
name: ent-isokaurene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ent-copalyl diphosphate = ent-isokaurene + diphosphate." [PMID:17141283]
is_a: GO:0010333 ! terpene synthase activity

[Term]
id: GO:0034282
name: ent-pimara-8(14),15-diene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ent-copalyl diphosphate = ent-pimara-8(14),15-diene + diphosphate." [RHEA:25543]
synonym: "ent-copalyl-diphosphate diphosphate-lyase [ent-pimara-8(14),15-diene-forming] activity" EXACT systematic_synonym [KEGG:R09121]
synonym: "ent-pimaradiene synthase activity" BROAD []
xref: EC:4.2.3.30
xref: KEGG:R09121
xref: MetaCyc:RXN-7788
xref: RHEA:25543
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0034283
name: syn-stemod-13(17)-ene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 9-alpha-copalyl diphosphate = stemod-13(17)-ene + diphosphate." [RHEA:25559]
synonym: "9alpha-copalyl-diphosphate diphosphate-lyase [stemod-13(17)-ene-forming] activity" EXACT systematic_synonym [KEGG:R09116]
synonym: "exo-stemodene synthase activity" EXACT []
synonym: "stemod-13(17)-ene synthase activity" EXACT []
synonym: "stemodene synthase activity" EXACT []
synonym: "syn-stemodene synthase activity" EXACT []
xref: EC:4.2.3.34
xref: KEGG:R09116
xref: MetaCyc:RXN-9291
xref: RHEA:25559
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0034284
name: response to monosaccharide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosaccharide stimulus." [GOC:mah]
synonym: "response to monosaccharide stimulus" EXACT [GOC:dos]
is_a: GO:0009743 ! response to carbohydrate

[Term]
id: GO:0034285
name: response to disaccharide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disaccharide stimulus." [GOC:sart]
synonym: "response to disaccharide stimulus" EXACT [GOC:dos]
is_a: GO:0009743 ! response to carbohydrate

[Term]
id: GO:0034286
name: response to maltose
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a maltose stimulus." [GOC:sart]
synonym: "response to maltose stimulus" EXACT [GOC:dos]
is_a: GO:0034285 ! response to disaccharide

[Term]
id: GO:0034287
name: detection of monosaccharide stimulus
namespace: biological_process
def: "The series of events in which a stimulus from a monosaccharide is received and converted into a molecular signal." [GOC:mah]
synonym: "perception of monosaccharide stimulus" RELATED []
is_a: GO:0009730 ! detection of carbohydrate stimulus
is_a: GO:0034284 ! response to monosaccharide

[Term]
id: GO:0034288
name: detection of disaccharide stimulus
namespace: biological_process
def: "The series of events in which a stimulus from a disaccharide is received and converted into a molecular signal." [GOC:sart]
synonym: "perception of disaccharide stimulus" RELATED []
is_a: GO:0009730 ! detection of carbohydrate stimulus
is_a: GO:0034285 ! response to disaccharide

[Term]
id: GO:0034289
name: detection of maltose stimulus
namespace: biological_process
def: "The series of events in which a maltose stimulus is received by a cell and converted into a molecular signal." [GOC:sart]
synonym: "perception of maltose stimulus" RELATED []
is_a: GO:0034286 ! response to maltose
is_a: GO:0034288 ! detection of disaccharide stimulus

[Term]
id: GO:0034290
name: holin activity
namespace: molecular_function
def: "A compound function consisting of the regulated formation of a pore via oligomerisation of an existing pool of subunits in the plasma membrane.  The resulting channel activity directly or indirectly allows murein hydrolyases to access their cell wall substrate." [GOC:jh2, PMID:1406491, PMID:25157079]
is_a: GO:0015267 ! channel activity
relationship: part_of GO:0044660 ! cytolysis by virus via pore formation in host cell membrane

[Term]
id: GO:0034291
name: canonical holin activity
namespace: molecular_function
def: "A compound function consisting of the regulated formation of a pore via oligomerisation of an existing pool of subunits in the plasma membrane.  The resulting channel activity directly allows release of a fully-folded phage-encoded endolysin (murein-degradase) from the cell." [GOC:jh2, GOC:mah, PMID:1406491, PMID:25157079]
is_a: GO:0015266 ! protein channel activity
is_a: GO:0034290 ! holin activity

[Term]
id: GO:0034292
name: pinholin activity
namespace: molecular_function
def: "A compound function consisting of the regulated formation of a pore via oligomerisation of an existing pool of subunits in the plasma membrane.  The resulting ion channel activity indirectly allows endolysin (murein hydrolyases) to access their cell wall substrate by collapsing the proton motive force (PMF) across the membrane, allowing the endolysin to fold to an active form and hydrolyze bonds in the peptidoglycan cell wall." [GOC:jh2, GOC:mah, PMID:1406491, PMID:25157079]
is_a: GO:0005216 ! ion channel activity
is_a: GO:0034290 ! holin activity

[Term]
id: GO:0034293
name: sexual sporulation
namespace: biological_process
def: "The formation of spores derived from the products of meiosis." [GOC:mah]
subset: goslim_aspergillus
synonym: "meiotic spore formation" EXACT []
synonym: "meiotic sporulation" EXACT []
synonym: "sexual spore formation" EXACT []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0043934 ! sporulation
is_a: GO:1903046 ! meiotic cell cycle process
intersection_of: GO:0043934 ! sporulation
intersection_of: part_of GO:0051321 ! meiotic cell cycle
relationship: part_of GO:0019953 ! sexual reproduction
relationship: part_of GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0034294
name: sexual spore wall assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a sexual spore wall, the specialized envelope lying outside the cell membrane of a spore derived from a product of meiosis." [GOC:mah]
synonym: "sexual spore wall formation" EXACT []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0042244 ! spore wall assembly
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0034293 ! sexual sporulation

[Term]
id: GO:0034295
name: basidiospore formation
namespace: biological_process
def: "The process in which spores form outside a specialized end cell known as a basidium. Basidia are characteristic of the basidiomycete fungi (phylum Basidiomycota), and give rise to spores that each contain a haploid nucleus that is the product of meiosis. The spores are usually attached to the basidium by short spikes called sterigmata (singular: sterigma). In most basidiomycetes there are four sterigmata (and four spores) to a basidium." [GOC:di, GOC:ds, GOC:mah, GOC:mcc, http://www.gsbs.utmb.edu/microbook/ch073.htm, http://www.ilmyco.gen.chicago.il.us/Terms/basid133.html]
comment: Note that basidiospores and basidia are separate biological structures. The basidium is the structure that bear the basidiospores, but the development of the basidium is a different process than the formation of the basidiospores themselves. For this reason, GO:0034295 basidiospore formation and GO:0075313 basidium development are different terms and are not linked.
is_a: GO:0043935 ! sexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0034296
name: zygospore formation
namespace: biological_process
def: "The process in which zygospores are formed. Zygospores are characteristic of the zygomycete fungi (phylum Zygomycota) thick-walled and darkly colored, and usually heavily ornamented as well, with many spines or ridges. It is formed between two specialized organs called suspensors, which are themselves usually heavily ornamented, one from each mating partner. The zygospore forms between them and then breaks away." [GOC:ds, GOC:mah, http://www.ilmyco.gen.chicago.il.us/Terms/zygos581.html]
is_a: GO:0043935 ! sexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0034297
name: oidium formation
namespace: biological_process
def: "The process in which oidia, a type of asexual spore found in fungi, are formed. Oidia are borne a few at a time on very simple hyphae that protrude a short distance into the substrate, and are usually presumed not to constitute the main reproductive strategy of the fungus." [GOC:mah, http://www.ilmyco.gen.chicago.il.us/Terms/oidiu163.html]
is_a: GO:0030436 ! asexual sporulation

[Term]
id: GO:0034298
name: arthrospore formation
namespace: biological_process
def: "The formation of conidia by the conversion of a pre-existing hypha. An arthrospore is produced by the last cell on a hypha breaking off and dispersing. Usually the walls thicken and the cell(s) separates before swelling of each spore. Sometimes further septa form in each cell prior to disarticulation." [GOC:mah, http://bugs.bio.usyd.edu.au/Mycology/Glossary/glossary_a_b.shtml#arthrospore, http://www.ilmyco.gen.chicago.il.us/Terms/arthr620.html]
synonym: "arthroconidium formation" EXACT [http://medical.merriam-webster.com/medical/medical?book=Medical&va=arthroconidium]
is_a: GO:0048315 ! conidium formation

[Term]
id: GO:0034299
name: reproductive blastospore formation
namespace: biological_process
def: "The formation of a spore following the marked enlargement of part of a cell before separation by a septum. Blastospores are a type of asexual spore found in some fungi, most notably the class Glomeromycota." [GOC:mah, http://bugs.bio.usyd.edu.au/Mycology/Glossary/glossary_a_b.shtml#blastospore, http://bugs.bio.usyd.edu.au/Mycology/Taxonomy/glomeromycota.shtml]
comment: Note that this term should not be confused with the usage of 'blastospore' to mean any yeast-form fungal cell, as in Candida species.
synonym: "blastoconidium formation" EXACT [http://cancerweb.ncl.ac.uk/cgi-bin/omd?Blastoconidium]
is_a: GO:0048315 ! conidium formation

[Term]
id: GO:0034300
name: sporangiospore formation
namespace: biological_process
def: "The process in which sporangiospores, a type of asexual spore found in fungi, are formed. Sporangiospores are formed within sac-like structure, the sporangium, following the division of the cytoplasm." [GOC:ds, GOC:mah, http://bugs.bio.usyd.edu.au/Mycology/Glossary/glossary_n_z.shtml]
is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0034301
name: endospore formation
namespace: biological_process
def: "The process in which a cell gives rise to an endospore, a dormant, highly resistant spore with a thick wall that forms within the mother cell. Endospores are produced by some low G+C Gram-positive bacteria in response to harsh conditions." [GOC:ds, GOC:mah, ISBN:0470090278]
is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0034302
name: akinete formation
namespace: biological_process
def: "The process in which an akinete, a thick-walled (encysted) dormant cell derived from the enlargement of a vegetative cell, is formed. Akinetes typically have granular cytoplasm, are more resistant to environmental extremes than vegetative cells, and are characteristic of several groups of Cyanobacteria." [GOC:ds, GOC:mah, http://www.msu.edu/course/bot/423/algalglossary.htm#Reproductive, PMID:11948167]
is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0034303
name: myxospore formation
namespace: biological_process
def: "The process in which differentiated, resting cells are formed, usually within a fruiting body by Myxobacteria. The myxospore is more resistant to high temperature, dessication, and UV than vegetative myxobacteria." [GOC:ds, ISBN:0122268008]
is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0034304
name: actinomycete-type spore formation
namespace: biological_process
def: "The process in which differentiated, resting cells are formed from a substrate mycelium; characteristic of many members of the order Actinomycetales." [GOC:ds, ISBN:0122268008]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0022413 ! reproductive process in single-celled organism
is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore
is_a: GO:0044702 ! single organism reproductive process

[Term]
id: GO:0034305
name: regulation of asexual sporulation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of spore formation from the products of mitosis." [GOC:mah]
synonym: "regulation of asexual spore formation" EXACT []
synonym: "regulation of mitotic spore formation" EXACT []
synonym: "regulation of mitotic sporulation" EXACT []
is_a: GO:0043937 ! regulation of sporulation
is_a: GO:1903664 ! regulation of asexual reproduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030436 ! asexual sporulation
relationship: regulates GO:0030436 ! asexual sporulation

[Term]
id: GO:0034306
name: regulation of sexual sporulation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of spore formation from the products of meiosis. An example of this is found in Saccharomyces cerevisiae." [GOC:mah]
synonym: "MAPKKK cascade during sporulation" RELATED []
synonym: "regulation of meiotic spore formation" EXACT []
synonym: "regulation of meiotic sporulation" EXACT []
synonym: "regulation of sexual spore formation" EXACT []
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0042173 ! regulation of sporulation resulting in formation of a cellular spore
is_a: GO:0043900 ! regulation of multi-organism process
is_a: GO:0051445 ! regulation of meiotic cell cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034293 ! sexual sporulation
relationship: regulates GO:0034293 ! sexual sporulation

[Term]
id: GO:0034307
name: regulation of ascospore formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ascospore formation. An example of this process is found in Saccharomyces cerevisiae." [GOC:mah]
synonym: "MAPKKK cascade during sporulation" RELATED []
is_a: GO:0043940 ! regulation of sexual sporulation resulting in formation of a cellular spore
is_a: GO:0060284 ! regulation of cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030437 ! ascospore formation
relationship: regulates GO:0030437 ! ascospore formation

[Term]
id: GO:0034308
name: primary alcohol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving primary alcohols. A primary alcohol is any alcohol in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it." [CHEBI:15734, GOC:mah]
subset: gosubset_prok
synonym: "monohydric alcohol metabolic process" EXACT [GOC:curators]
synonym: "primary alcohol metabolism" EXACT [GOC:mah]
is_a: GO:0006066 ! alcohol metabolic process

[Term]
id: GO:0034309
name: primary alcohol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of primary alcohols. A primary alcohol is any alcohol in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it." [CHEBI:15734, GOC:mah]
subset: gosubset_prok
synonym: "monohydric alcohol biosynthetic process" EXACT [GOC:curators]
synonym: "primary alcohol anabolism" EXACT [GOC:mah]
synonym: "primary alcohol biosynthesis" EXACT [GOC:mah]
synonym: "primary alcohol formation" EXACT [GOC:mah]
synonym: "primary alcohol synthesis" EXACT [GOC:mah]
is_a: GO:0034308 ! primary alcohol metabolic process
is_a: GO:0046165 ! alcohol biosynthetic process

[Term]
id: GO:0034310
name: primary alcohol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of primary alcohols. A primary alcohol is any alcohol in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it." [CHEBI:15734, GOC:mah]
subset: gosubset_prok
synonym: "monohydric alcohol catabolic process" EXACT [GOC:curators]
synonym: "primary alcohol breakdown" EXACT [GOC:mah]
synonym: "primary alcohol catabolism" EXACT [GOC:mah]
synonym: "primary alcohol degradation" EXACT [GOC:mah]
is_a: GO:0034308 ! primary alcohol metabolic process
is_a: GO:0046164 ! alcohol catabolic process

[Term]
id: GO:0034311
name: diol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a diol, a compound that contains two hydroxy groups, generally assumed to be, but not necessarily, alcoholic." [CHEBI:23824]
subset: gosubset_prok
synonym: "dihydric alcohol metabolic process" RELATED []
synonym: "diol metabolism" EXACT []
is_a: GO:0019751 ! polyol metabolic process

[Term]
id: GO:0034312
name: diol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a diol, any alcohol containing two hydroxyl groups attached to saturated carbon atoms." [CHEBI:23824, GOC:mah]
synonym: "dihydric alcohol biosynthetic process" EXACT []
synonym: "diol anabolism" EXACT []
synonym: "diol biosynthesis" EXACT []
synonym: "diol formation" EXACT []
synonym: "diol synthesis" EXACT []
is_a: GO:0034311 ! diol metabolic process
is_a: GO:0046173 ! polyol biosynthetic process

[Term]
id: GO:0034313
name: diol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a diol, any alcohol containing two hydroxyl groups attached to saturated carbon atoms." [CHEBI:23824, GOC:mah]
synonym: "dihydric alcohol catabolic process" EXACT []
synonym: "diol breakdown" EXACT []
synonym: "diol catabolism" EXACT []
synonym: "diol degradation" EXACT []
is_a: GO:0034311 ! diol metabolic process
is_a: GO:0046174 ! polyol catabolic process

[Term]
id: GO:0034314
name: Arp2/3 complex-mediated actin nucleation
namespace: biological_process
def: "The actin nucleation process in which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins." [GOC:mah, PMID:16959963, PMID:18640983]
synonym: "actin filament branch nucleation" EXACT []
synonym: "branched actin filament nucleation" EXACT []
is_a: GO:0045010 ! actin nucleation

[Term]
id: GO:0034315
name: regulation of Arp2/3 complex-mediated actin nucleation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins." [GOC:mah]
is_a: GO:0051125 ! regulation of actin nucleation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034314 ! Arp2/3 complex-mediated actin nucleation
relationship: regulates GO:0034314 ! Arp2/3 complex-mediated actin nucleation

[Term]
id: GO:0034316
name: negative regulation of Arp2/3 complex-mediated actin nucleation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins." [GOC:mah, PMID:16959963]
is_a: GO:0034315 ! regulation of Arp2/3 complex-mediated actin nucleation
is_a: GO:0051126 ! negative regulation of actin nucleation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034314 ! Arp2/3 complex-mediated actin nucleation
relationship: negatively_regulates GO:0034314 ! Arp2/3 complex-mediated actin nucleation

[Term]
id: GO:0034317
name: nicotinic acid riboside kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + nicotinic acid riboside = ADP + nicotinic acid mononucleotide." [PMID:17914902]
xref: MetaCyc:RXN-8443
is_a: GO:0019206 ! nucleoside kinase activity

[Term]
id: GO:0034318
name: alcohol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an acyl group to an oxygen atom on an alcohol acceptor molecule." [GOC:mah]
synonym: "acyl-CoA:alcohol O-acyltransferase activity" EXACT []
synonym: "acyl-CoA:ethanol O-acyltransferase" NARROW []
synonym: "acyl-coenzymeA:alcohol O-acyltransferase activity" EXACT []
synonym: "acyl-coenzymeA:ethanol O-acyltransferase activity" NARROW []
synonym: "AEATase activity" NARROW []
synonym: "alcohol acyltransferase activity" EXACT []
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0034319
name: alcohol O-butanoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: butanoyl-CoA + an alcohol = CoA + a butyl ester." [GOC:mah, PMID:16361250]
is_a: GO:0016413 ! O-acetyltransferase activity
is_a: GO:0034318 ! alcohol O-acyltransferase activity
is_a: GO:0034323 ! O-butanoyltransferase activity

[Term]
id: GO:0034320
name: alcohol O-hexanoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: hexanoyl-CoA + an alcohol = CoA + a hexyl ester." [GOC:mah, PMID:16361250]
is_a: GO:0016413 ! O-acetyltransferase activity
is_a: GO:0034318 ! alcohol O-acyltransferase activity
is_a: GO:0034324 ! O-hexanoyltransferase activity

[Term]
id: GO:0034321
name: alcohol O-octanoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: octanoyl-CoA + an alcohol = CoA + an octyl ester." [GOC:mah, PMID:16361250]
is_a: GO:0016413 ! O-acetyltransferase activity
is_a: GO:0016414 ! O-octanoyltransferase activity
is_a: GO:0034318 ! alcohol O-acyltransferase activity

[Term]
id: GO:0034322
name: alcohol O-decanoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: decanoyl-CoA + an alcohol = CoA + a decyl ester." [GOC:mah, PMID:16361250]
is_a: GO:0016413 ! O-acetyltransferase activity
is_a: GO:0034318 ! alcohol O-acyltransferase activity
is_a: GO:0034325 ! O-decanoyltransferase activity

[Term]
id: GO:0034323
name: O-butanoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a butyl group to an oxygen atom on the acceptor molecule." [GOC:mah]
is_a: GO:0008374 ! O-acyltransferase activity
is_a: GO:0034326 ! butanoyltransferase activity

[Term]
id: GO:0034324
name: O-hexanoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a hexyl group to an oxygen atom on the acceptor molecule." [GOC:mah]
is_a: GO:0008374 ! O-acyltransferase activity
is_a: GO:0034327 ! hexanoyltransferase activity

[Term]
id: GO:0034325
name: O-decanoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a decyl group to an oxygen atom on the acceptor molecule." [GOC:mah]
is_a: GO:0008374 ! O-acyltransferase activity
is_a: GO:0034328 ! decanoyltransferase activity

[Term]
id: GO:0034326
name: butanoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a butanoyl (CH3-[CH2]2-CO-) group to an acceptor molecule." [GOC:mah]
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0034327
name: hexanoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a hexanoyl (CH3-[CH2]4-CO-) group to an acceptor molecule." [GOC:mah]
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0034328
name: decanoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a decanoyl (CH3-[CH2]8-CO-) group to an acceptor molecule." [GOC:mah]
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0034329
name: cell junction assembly
namespace: biological_process
def: "A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction." [GOC:mah]
xref: Reactome:REACT_102961 "Cell junction organization, Canis familiaris"
xref: Reactome:REACT_103254 "Cell junction organization, Bos taurus"
xref: Reactome:REACT_20676 "Cell junction organization, Homo sapiens"
xref: Reactome:REACT_30673 "Cell junction organization, Danio rerio"
xref: Reactome:REACT_81158 "Cell junction organization, Taeniopygia guttata"
xref: Reactome:REACT_82932 "Cell junction organization, Mus musculus"
xref: Reactome:REACT_84768 "Cell junction organization, Drosophila melanogaster"
xref: Reactome:REACT_92671 "Cell junction organization, Caenorhabditis elegans"
xref: Reactome:REACT_94741 "Cell junction organization, Rattus norvegicus"
xref: Reactome:REACT_96353 "Cell junction organization, Gallus gallus"
xref: Reactome:REACT_96361 "Cell junction organization, Xenopus tropicalis"
xref: Reactome:REACT_98047 "Cell junction organization, Sus scrofa"
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0034330 ! cell junction organization

[Term]
id: GO:0034330
name: cell junction organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix." [GOC:dph, GOC:jl, GOC:mah]
subset: goslim_chembl
subset: goslim_generic
synonym: "cell junction assembly and maintenance" EXACT []
synonym: "cell junction biogenesis" RELATED []
synonym: "cell junction organisation" EXACT [GOC:mah]
is_a: GO:0016043 ! cellular component organization
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0034331
name: cell junction maintenance
namespace: biological_process
def: "The organization process that preserves a cell junction in a stable functional or structural state. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix." [GOC:dph, GOC:jl, GOC:mah]
is_a: GO:0034330 ! cell junction organization
is_a: GO:0043954 ! cellular component maintenance

[Term]
id: GO:0034332
name: adherens junction organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:dph, GOC:jl, GOC:mah]
synonym: "adherens junction assembly and maintenance" EXACT []
synonym: "adherens junction organisation" EXACT [GOC:curators]
xref: Reactome:REACT_106603 "Adherens junctions interactions, Xenopus tropicalis"
xref: Reactome:REACT_108185 "Adherens junctions interactions, Sus scrofa"
xref: Reactome:REACT_110805 "Adherens junctions interactions, Gallus gallus"
xref: Reactome:REACT_115366 "Adherens junctions interactions, Drosophila melanogaster"
xref: Reactome:REACT_19195 "Adherens junctions interactions, Homo sapiens"
xref: Reactome:REACT_28088 "Adherens junctions interactions, Canis familiaris"
xref: Reactome:REACT_28998 "Adherens junctions interactions, Mus musculus"
xref: Reactome:REACT_32787 "Adherens junctions interactions, Danio rerio"
xref: Reactome:REACT_86794 "Adherens junctions interactions, Bos taurus"
xref: Reactome:REACT_90289 "Adherens junctions interactions, Taeniopygia guttata"
xref: Reactome:REACT_92943 "Adherens junctions interactions, Rattus norvegicus"
is_a: GO:0045216 ! cell-cell junction organization

[Term]
id: GO:0034333
name: adherens junction assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:mah]
synonym: "adherens junction formation" EXACT []
is_a: GO:0034329 ! cell junction assembly
is_a: GO:0034332 ! adherens junction organization

[Term]
id: GO:0034334
name: adherens junction maintenance
namespace: biological_process
def: "The maintenance of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:mah]
is_a: GO:0034331 ! cell junction maintenance
is_a: GO:0034332 ! adherens junction organization

[Term]
id: GO:0034335
name: DNA supercoiling activity
namespace: molecular_function
def: "Catalytic introduction of supercoils in a DNA molecule or region thereof. In bacteria, negative supercoils are only introduced by DNA gyrase, a type II topoisomerase, but not all DNA gyrases are capable of introducing supercoils. In bacteria, the level of supercoiling varies widely between species and has been characterized properly in only a handful of organisms. The best characterized enzyme, from E.coli, is exceptionally proficient at supercoiling and this ability is not representative of all bacteria." [GOC:mah]
comment: Note that this term was reinstated from obsolete.
synonym: "DNA gyrase activity" EXACT []
synonym: "DNA-gyrase activity" EXACT []
is_a: GO:0003918 ! DNA topoisomerase type II (ATP-hydrolyzing) activity

[Term]
id: GO:0034336
name: misfolded RNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA molecule that has assumed an incorrect conformation." [GOC:mah, PMID:10393192]
synonym: "RNA chaperone" RELATED []
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0034337
name: RNA folding
namespace: biological_process
def: "The process of assisting in the covalent and noncovalent assembly of single or multimeric RNAs into the correct tertiary structure." [GOC:mah, PMID:10393192]
synonym: "RNA chaperone" RELATED []
is_a: GO:0016070 ! RNA metabolic process

[Term]
id: GO:0034338
name: short-chain carboxylesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion, where the carboxylic chain has 8 or fewer carbon atoms." [GOC:jp]
subset: gosubset_prok
synonym: "butyrate esterase activity" NARROW []
synonym: "butyryl esterase activity" NARROW []
synonym: "methylbutyrase activity" NARROW []
synonym: "methylbutyrate esterase activity" NARROW []
synonym: "monobutyrase activity" NARROW []
synonym: "propionyl esterase activity" NARROW []
synonym: "short-chain esterase activity" BROAD []
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0034339
name: obsolete regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor
namespace: biological_process
def: "OBSOLETE. Any process in which a ligand-bound hormone receptor acts in the nucleus to modulate the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GO_REF:0000021, GOC:mah, GOC:mh]
comment: This term was added by GO_REF:0000021. This term was made obsolete because it is unclear whether the term represents the action of the receptor or the entire process of transcription regulation. The term 'nuclear hormone receptor' is also misleading since many of these receptors reside in the cytoplasm until they are bound by a ligand.
synonym: "regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor" EXACT []
is_obsolete: true
consider: GO:0004879
consider: GO:0006357
consider: GO:0030522
consider: GO:0038049

[Term]
id: GO:0034340
name: response to type I interferon
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16681834]
synonym: "response to type I IFN" EXACT []
is_a: GO:0034097 ! response to cytokine
relationship: part_of GO:0045087 ! innate immune response

[Term]
id: GO:0034341
name: response to interferon-gamma
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon-gamma is also known as type II interferon." [GOC:add, ISBN:0126896631, PMID:15546383]
synonym: "response to gamma-interferon" RELATED []
synonym: "response to immune interferon" EXACT []
synonym: "response to type II IFN" BROAD []
synonym: "response to type II interferon" BROAD []
is_a: GO:0034097 ! response to cytokine
relationship: part_of GO:0045087 ! innate immune response

[Term]
id: GO:0034342
name: response to type III interferon
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type III interferon stimulus. Interferon lambda is the only member of the type III interferon found so far." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557]
synonym: "response to interferon-lambda" NARROW []
synonym: "response to type III IFN" EXACT []
is_a: GO:0034097 ! response to cytokine
relationship: part_of GO:0045087 ! innate immune response

[Term]
id: GO:0034343
name: type III interferon production
namespace: biological_process
def: "The appearance of type III interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon lambda is the only member of the type III interferon found so far." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557]
comment: Note that IL-28A, IL-28B, and IL-29 are types of interferon-lambda.
synonym: "type III IFN production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0034344
name: regulation of type III interferon production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of type III interferon production. Interferon lambda is the only member of the type III interferon found so far." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557]
comment: Note that IL-28A, IL-28B, and IL-29 are types of interferon-lambda.
synonym: "regulation of type III IFN production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034343 ! type III interferon production
relationship: regulates GO:0034343 ! type III interferon production

[Term]
id: GO:0034345
name: negative regulation of type III interferon production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of type III interferon production. Interferon lambda is the only member of the type III interferon found so far." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557]
comment: Note that IL-28A, IL-28B, and IL-29 are types of interferon-lambda.
synonym: "down regulation of type III interferon production" EXACT []
synonym: "down-regulation of type III interferon production" EXACT []
synonym: "downregulation of type III interferon production" EXACT []
synonym: "inhibition of type III interferon production" NARROW []
synonym: "negative regulation of type III IFN production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0034344 ! regulation of type III interferon production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034343 ! type III interferon production
relationship: negatively_regulates GO:0034343 ! type III interferon production

[Term]
id: GO:0034346
name: positive regulation of type III interferon production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of type III interferon production. Interferon lambda is the only member of the type III interferon found so far." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557]
comment: Note that IL-28A, IL-28B, and IL-29 are types of interferon-lambda.
synonym: "activation of type III interferon production" NARROW []
synonym: "positive regulation of type III IFN production" EXACT []
synonym: "stimulation of type III interferon production" NARROW []
synonym: "up regulation of type III interferon production" EXACT []
synonym: "up-regulation of type III interferon production" EXACT []
synonym: "upregulation of type III interferon production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0034344 ! regulation of type III interferon production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034343 ! type III interferon production
relationship: positively_regulates GO:0034343 ! type III interferon production

[Term]
id: GO:0034347
name: type III interferon binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type III interferon. Interferon lambda is the only member of the type III interferon found so far." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557]
comment: Note that IL-28A, IL-28B, and IL-29 are types of interferon-lambda.
synonym: "interferon-lambda binding" NARROW []
is_a: GO:0019961 ! interferon binding

[Term]
id: GO:0034348
name: type III interferon receptor activity
namespace: molecular_function
def: "Combining with a type III interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Interferon lambda is the only member of the type III interferon found so far." [GOC:add, GOC:signaling, ISBN:0126896631, PMID:15546383, PMID:16734557]
comment: Note that IL-28A, IL-28B, and IL-29 are types of interferon-lambda.
synonym: "interferon-lambda receptor activity" NARROW [PR:000001362]
is_a: GO:0004904 ! interferon receptor activity
relationship: has_part GO:0034347 ! type III interferon binding
relationship: part_of GO:0038196 ! type III interferon signaling pathway

[Term]
id: GO:0034349
name: glial cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a glial cell, a non-neuronal cell of the nervous system." [CL:0000125, GOC:mtg_apoptosis, GOC:sart]
synonym: "apoptosis of glia" EXACT []
synonym: "apoptosis of glial cells" EXACT []
synonym: "glia apoptosis" EXACT []
synonym: "glia programmed cell death by apoptosis" EXACT []
synonym: "glial cell apoptosis" NARROW []
synonym: "glial cell programmed cell death by apoptosis" EXACT []
synonym: "programmed cell death of glia by apoptosis" EXACT []
synonym: "programmed cell death of glial cells by apoptosis" EXACT []
synonym: "programmed cell death, glia" EXACT []
synonym: "programmed cell death, glial cells" EXACT []
is_a: GO:0006915 ! apoptotic process

[Term]
id: GO:0034350
name: regulation of glial cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of glial cell apoptotic process." [GOC:mah, GOC:mtg_apoptosis]
synonym: "regulation of glial cell apoptosis" RELATED []
is_a: GO:0042981 ! regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034349 ! glial cell apoptotic process
relationship: regulates GO:0034349 ! glial cell apoptotic process

[Term]
id: GO:0034351
name: negative regulation of glial cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of glial cell apoptotic process." [GOC:mah, GOC:mtg_apoptosis]
synonym: "down regulation of glial cell apoptosis" EXACT []
synonym: "down-regulation of glial cell apoptosis" EXACT []
synonym: "downregulation of glial cell apoptosis" EXACT []
synonym: "inhibition of glial cell apoptosis" NARROW []
synonym: "negative regulation of glial cell apoptosis" NARROW []
is_a: GO:0034350 ! regulation of glial cell apoptotic process
is_a: GO:0043066 ! negative regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034349 ! glial cell apoptotic process
relationship: negatively_regulates GO:0034349 ! glial cell apoptotic process

[Term]
id: GO:0034352
name: positive regulation of glial cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of glial cell apoptotic process." [GOC:mah, GOC:mtg_apoptosis]
synonym: "activation of glial cell apoptosis" NARROW []
synonym: "positive regulation of glial cell apoptosis" NARROW []
synonym: "stimulation of glial cell apoptosis" NARROW []
synonym: "up regulation of glial cell apoptosis" EXACT []
synonym: "up-regulation of glial cell apoptosis" EXACT []
synonym: "upregulation of glial cell apoptosis" EXACT []
is_a: GO:0034350 ! regulation of glial cell apoptotic process
is_a: GO:0043065 ! positive regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034349 ! glial cell apoptotic process
relationship: positively_regulates GO:0034349 ! glial cell apoptotic process

[Term]
id: GO:0034353
name: RNA pyrophosphohydrolase activity
namespace: molecular_function
def: "Catalysis of the removal of a 5' terminal pyrophosphate from the 5'-triphosphate end of an RNA, leaving a 5'-monophosphate end." [GOC:jh2, PMID:17612492, PMID:18202662]
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0034354
name: 'de novo' NAD biosynthetic process from tryptophan
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD), beginning with the synthesis of tryptophan from simpler precursors; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH." [PMID:17161604]
synonym: "de novo NAD biosynthetic process from tryptophan" RELATED []
is_a: GO:0006568 ! tryptophan metabolic process
is_a: GO:0034627 ! 'de novo' NAD biosynthetic process

[Term]
id: GO:0034355
name: NAD salvage
namespace: biological_process
def: "Any process that generates nicotinamide adenine dinucleotide (NAD) from derivatives of it, without de novo synthesis; salvage is usually from the degradation products nicotinic acid (Na) and nicotinamide (Nam)." [GOC:mah, PMID:12648681]
synonym: "NAD salvage pathway" EXACT []
is_a: GO:0009435 ! NAD biosynthetic process
is_a: GO:0019365 ! pyridine nucleotide salvage

[Term]
id: GO:0034356
name: NAD biosynthesis via nicotinamide riboside salvage pathway
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD) from the vitamin precursor nicotinamide riboside." [PMID:17482543]
synonym: "nicotinamide riboside salvage pathway" EXACT []
synonym: "NR salvage pathway" EXACT []
is_a: GO:0009435 ! NAD biosynthetic process

[Term]
id: GO:0034357
name: photosynthetic membrane
namespace: cellular_component
def: "A membrane enriched in complexes formed of reaction centers, accessory pigments and electron carriers, in which photosynthetic reactions take place." [GOC:ds, GOC:mah]
subset: gosubset_prok
is_a: GO:0016020 ! membrane
is_a: GO:0044436 ! thylakoid part
relationship: part_of GO:0009579 ! thylakoid

[Term]
id: GO:0034358
name: plasma lipoprotein particle
namespace: cellular_component
def: "A spherical particle with a hydrophobic core of triglycerides and/or cholesterol esters, surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Plasma lipoprotein particles transport lipids, which are non-covalently associated with the particles, in the blood or lymph." [GOC:BHF, GOC:expert_pt, GOC:rl]
is_a: GO:0044421 ! extracellular region part
is_a: GO:1990777 ! lipoprotein particle
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0034359
name: mature chylomicron
namespace: cellular_component
def: "A chylomicron that contains apolipoprotein C2 (APOC2), a cofactor for lipoprotein lipase (LPL) activity, and has a mean diameter of 500 nm and density of 0.95g/ml. Mature chylomicron particles transport exogenous (dietary) lipids from the intestines to other body tissues, via the blood and lymph." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]
is_a: GO:0042627 ! chylomicron

[Term]
id: GO:0034360
name: chylomicron remnant
namespace: cellular_component
def: "A lipoprotein particle that is derived from a mature chylomicron particle by the removal of triglycerides from the chylomicron core by lipoprotein lipase and the subsequent loss of surface components. It characteristically contains apolipoprotein E (APOE) and is cleared from the blood by the liver." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]
is_a: GO:0042627 ! chylomicron

[Term]
id: GO:0034361
name: very-low-density lipoprotein particle
namespace: cellular_component
def: "A triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm. It is found in blood and transports endogenous products (newly synthesized cholesterol and triglycerides) from the liver." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]
synonym: "very-low-density lipoprotein complex" EXACT []
synonym: "VLDL complex" EXACT []
synonym: "VLDL particle" EXACT []
is_a: GO:0034385 ! triglyceride-rich lipoprotein particle

[Term]
id: GO:0034362
name: low-density lipoprotein particle
namespace: cellular_component
def: "A lipoprotein particle, rich in cholesterol esters and low in triglycerides that is typically composed of APOB100 and APOE and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm. LDL particles are formed from VLDL particles (via IDL) by the loss of triglyceride and gain of cholesterol ester. They transport endogenous cholesterol (and to some extent triglycerides) from peripheral tissues back to the liver." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]
synonym: "LDL complex" EXACT []
synonym: "LDL particle" EXACT []
synonym: "low-density lipoprotein complex" EXACT []
is_a: GO:0034358 ! plasma lipoprotein particle

[Term]
id: GO:0034363
name: intermediate-density lipoprotein particle
namespace: cellular_component
def: "A triglyceride-rich lipoprotein particle that typically contains APOB100, APOE and APOCs and has a density of 1.006-1.019 g/ml and a diameter of between 25-30 nm. IDL particles are found in blood and are formed by the delipidation of very-low-density lipoprotein particles (VLDL). IDL particles are removed from blood by the liver, following binding to the APOE receptor, or are converted to low-density lipoprotein (LDL)." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]
synonym: "IDL complex" EXACT []
synonym: "IDL particle" EXACT []
synonym: "intermediate-density lipoprotein complex" EXACT []
is_a: GO:0034385 ! triglyceride-rich lipoprotein particle

[Term]
id: GO:0034364
name: high-density lipoprotein particle
namespace: cellular_component
def: "A lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE; found in blood and carries lipids from body tissues to the liver as part of the reverse cholesterol transport process." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:pde, GOC:rl]
synonym: "HDL complex" EXACT []
synonym: "HDL particle" EXACT []
synonym: "HDL2" RELATED []
synonym: "HDL3" RELATED []
synonym: "high-density lipoprotein class complex" EXACT []
is_a: GO:0034358 ! plasma lipoprotein particle

[Term]
id: GO:0034365
name: discoidal high-density lipoprotein particle
namespace: cellular_component
def: "A newly formed high-density lipoprotein particle; consists of a phospholipid bilayer surrounded by two or more APOA1 molecules. The discoidal HDL particle is formed when lipid-free or lipid-poor APOA1 acquires phospholipids and unesterified cholesterol from either cell membranes or triglyceride-rich lipoproteins (undergoing lipolysis by lipoprotein lipase)." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]
synonym: "discoidal HDL" EXACT []
synonym: "nascent HDL" EXACT []
synonym: "nascent high-density lipoprotein particle" EXACT []
is_a: GO:0034364 ! high-density lipoprotein particle

[Term]
id: GO:0034366
name: spherical high-density lipoprotein particle
namespace: cellular_component
def: "A mature high-density lipoprotein (HDL) particle, converted from discoidal HDL particles following the esterification of cholesterol in the particle by phosphatidylcholine-sterol O-acyltransferase (lecithin cholesterol acyltransferase; LCAT)." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]
synonym: "mature HDL" EXACT []
synonym: "mature high-density lipoprotein particle" EXACT []
synonym: "spherical HDL" EXACT []
is_a: GO:0034364 ! high-density lipoprotein particle

[Term]
id: GO:0034367
name: macromolecular complex remodeling
namespace: biological_process
def: "The acquisition, loss, or modification of macromolecules within a complex, resulting in the alteration of an existing complex." [GOC:BHF, GOC:mah, GOC:mtg_mpo, GOC:rl]
is_a: GO:0043933 ! macromolecular complex subunit organization

[Term]
id: GO:0034368
name: protein-lipid complex remodeling
namespace: biological_process
def: "The acquisition, loss or modification of a protein or lipid within a protein-lipid complex." [GOC:BHF, GOC:mah, GOC:rl]
is_a: GO:0034367 ! macromolecular complex remodeling
is_a: GO:0071825 ! protein-lipid complex subunit organization

[Term]
id: GO:0034369
name: plasma lipoprotein particle remodeling
namespace: biological_process
def: "The acquisition, loss or modification of a protein or lipid within a plasma lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the esterification of cholesterol by phosphatidylcholine-sterol O-acyltransferase (lecithin cholesterol acyltransferase; LCAT)." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]
is_a: GO:0034368 ! protein-lipid complex remodeling
is_a: GO:0071827 ! plasma lipoprotein particle organization
relationship: part_of GO:0097006 ! regulation of plasma lipoprotein particle levels

[Term]
id: GO:0034370
name: triglyceride-rich lipoprotein particle remodeling
namespace: biological_process
def: "The acquisition, loss or modification of a protein or lipid within a triglyceride-rich lipoprotein particle, including the hydrolysis of triglyceride by lipoprotein lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride from a triglyceride-rich lipoprotein particle." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]
synonym: "triacylglycerol-rich lipoprotein particle remodeling" EXACT [GOC:mah]
is_a: GO:0034369 ! plasma lipoprotein particle remodeling

[Term]
id: GO:0034371
name: chylomicron remodeling
namespace: biological_process
def: "The acquisition, loss or modification of a protein or lipid within a chylomicron, including the hydrolysis of triglyceride by lipoprotein lipase and the subsequent loss of free fatty acid." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]
synonym: "chylomicron remnant formation" RELATED []
is_a: GO:0034370 ! triglyceride-rich lipoprotein particle remodeling

[Term]
id: GO:0034372
name: very-low-density lipoprotein particle remodeling
namespace: biological_process
def: "The acquisition, loss or modification of a protein or lipid within a very-low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase or lipoprotein lipase and the subsequent loss of free fatty acid." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]
synonym: "IDL formation" RELATED []
synonym: "intermediate-density lipoprotein particle formation" RELATED []
synonym: "VLDL remodeling" EXACT []
is_a: GO:0034370 ! triglyceride-rich lipoprotein particle remodeling

[Term]
id: GO:0034373
name: intermediate-density lipoprotein particle remodeling
namespace: biological_process
def: "The acquisition, loss or modification of a protein or lipid within an intermediate-density lipoprotein particle." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]
synonym: "IDL remodeling" EXACT []
synonym: "LDL formation" RELATED []
synonym: "low-density lipoprotein particle formation" RELATED []
is_a: GO:0034370 ! triglyceride-rich lipoprotein particle remodeling

[Term]
id: GO:0034374
name: low-density lipoprotein particle remodeling
namespace: biological_process
def: "The acquisition, loss or modification of a protein or lipid within a low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters from LDL to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride to LDL." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]
synonym: "LDL remodeling" EXACT []
synonym: "small dense LDL formation" RELATED [GOC:BHF]
synonym: "small dense low-density lipoprotein particle formation" RELATED [GOC:BHF]
is_a: GO:0034369 ! plasma lipoprotein particle remodeling

[Term]
id: GO:0034375
name: high-density lipoprotein particle remodeling
namespace: biological_process
def: "The acquisition, loss or modification of a protein or lipid within a high-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters from LDL to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride to LDL." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]
synonym: "HDL remodeling" EXACT []
is_a: GO:0034369 ! plasma lipoprotein particle remodeling

[Term]
id: GO:0034376
name: conversion of discoidal high-density lipoprotein particle to spherical high-density lipoprotein particle
namespace: biological_process
def: "The process in which a discoidal high-density lipoprotein (HDL) particle acquires additional lipid or protein molecules, and cholesterol in the particle is converted to tightly bound cholesterol esters by the action of phosphatidylcholine-sterol O-acyltransferase (lecithin cholesterol acyltransferase; LCAT), resulting in the formation of a spherical HDL particle." [GOC:BHF, GOC:mah, GOC:pde]
synonym: "conversion of discoidal HDL to spherical HDL" EXACT []
synonym: "discoidal HDL remodeling" RELATED []
synonym: "discoidal high-density lipoprotein remodeling" RELATED []
is_a: GO:0034375 ! high-density lipoprotein particle remodeling

[Term]
id: GO:0034377
name: plasma lipoprotein particle assembly
namespace: biological_process
def: "The aggregation and arrangement of proteins and lipids to form a plasma lipoprotein particle." [GOC:BHF, GOC:mah]
is_a: GO:0065005 ! protein-lipid complex assembly
is_a: GO:0071827 ! plasma lipoprotein particle organization
relationship: part_of GO:0097006 ! regulation of plasma lipoprotein particle levels

[Term]
id: GO:0034378
name: chylomicron assembly
namespace: biological_process
def: "The aggregation and arrangement of proteins and lipids in the intestine to form a chylomicron." [GOC:BHF, GOC:mah]
is_a: GO:0034377 ! plasma lipoprotein particle assembly

[Term]
id: GO:0034379
name: very-low-density lipoprotein particle assembly
namespace: biological_process
def: "The aggregation and arrangement of proteins and lipids in the liver to form a very-low-density lipoprotein particle." [GOC:BHF, GOC:mah]
synonym: "VLDL assembly" EXACT []
is_a: GO:0034377 ! plasma lipoprotein particle assembly

[Term]
id: GO:0034380
name: high-density lipoprotein particle assembly
namespace: biological_process
def: "The aggregation and arrangement of proteins and lipids to form a high-density lipoprotein particle." [GOC:BHF, GOC:mah]
synonym: "HDL assembly" EXACT []
is_a: GO:0034377 ! plasma lipoprotein particle assembly

[Term]
id: GO:0034381
name: plasma lipoprotein particle clearance
namespace: biological_process
def: "The process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:ascb_2009, GOC:BHF, GOC:dph, GOC:mah, GOC:tb]
synonym: "lipoprotein particle clearance" EXACT [GOC:mah]
is_a: GO:0044707 ! single-multicellular organism process
relationship: has_part GO:0006898 ! receptor-mediated endocytosis
relationship: has_part GO:0071829 ! plasma lipoprotein particle disassembly
relationship: part_of GO:0097006 ! regulation of plasma lipoprotein particle levels

[Term]
id: GO:0034382
name: chylomicron remnant clearance
namespace: biological_process
def: "The process in which a chylomicron remnant is removed from the blood via receptor-mediated endocytosis into liver cells and its constituent parts degraded." [GOC:BHF, GOC:mah, GOC:pde]
is_a: GO:0071830 ! triglyceride-rich lipoprotein particle clearance

[Term]
id: GO:0034383
name: low-density lipoprotein particle clearance
namespace: biological_process
def: "The process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:mah]
synonym: "LDL clearance" EXACT []
is_a: GO:0034381 ! plasma lipoprotein particle clearance
relationship: has_part GO:0090495 ! low-density lipoprotein particle disassembly

[Term]
id: GO:0034384
name: high-density lipoprotein particle clearance
namespace: biological_process
def: "The process in which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:mah]
synonym: "HDL clearance" EXACT []
is_a: GO:0034381 ! plasma lipoprotein particle clearance

[Term]
id: GO:0034385
name: triglyceride-rich lipoprotein particle
namespace: cellular_component
def: "A plasma lipoprotein particle that has a hydrophobic core enriched in triglycerides surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Triglyceride-rich lipoproteinparticles transport lipids, which are non-covalently associated with the particles, in the blood." [GOC:BHF, GOC:mah, GOC:rl]
synonym: "triacylglycerol-rich lipoprotein particle" EXACT [GOC:mah]
is_a: GO:0034358 ! plasma lipoprotein particle

[Term]
id: GO:0034386
name: 4-aminobutyrate:2-oxoglutarate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate." [EC:2.6.1.19, GOC:mah]
synonym: "4-aminobutanoate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.19]
synonym: "4-aminobutyrate-2-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.19]
synonym: "4-aminobutyrate-2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.19]
synonym: "4-aminobutyrate-2-oxoglutarate transaminase activity" EXACT [EC:2.6.1.19]
synonym: "4-aminobutyric acid 2-ketoglutaric acid aminotransferase activity" EXACT [EC:2.6.1.19]
synonym: "GABA-2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.19]
synonym: "GABA-2-oxoglutarate transaminase activity" EXACT [EC:2.6.1.19]
synonym: "GABA-alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.19]
synonym: "GABA-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.19]
synonym: "GABA-alpha-ketoglutaric acid transaminase activity" EXACT [EC:2.6.1.19]
synonym: "GABA-alpha-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.19]
synonym: "GABA-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.19]
synonym: "GABA-oxoglutarate transaminase activity" EXACT [EC:2.6.1.19]
synonym: "gamma-aminobutyrate-alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.19]
synonym: "gamma-aminobutyrate-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.19]
synonym: "gamma-aminobutyrate:alpha-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.19]
synonym: "gamma-aminobutyric acid-2-oxoglutarate transaminase activity" EXACT [EC:2.6.1.19]
synonym: "gamma-aminobutyric acid-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.19]
synonym: "gamma-aminobutyric acid-alpha-ketoglutaric acid aminotransferase activity" EXACT [EC:2.6.1.19]
xref: MetaCyc:GABATRANSAM-RXN
is_a: GO:0003867 ! 4-aminobutyrate transaminase activity

[Term]
id: GO:0034387
name: 4-aminobutyrate:pyruvate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-aminobutanoate + pyruvate = succinate semialdehyde + alanine." [EC:2.6.1.19, GOC:mah]
synonym: "gamma-aminobutyric acid pyruvate transaminase activity" EXACT [EC:2.6.1.19]
xref: MetaCyc:RXN-6902
is_a: GO:0003867 ! 4-aminobutyrate transaminase activity

[Term]
id: GO:0034388
name: Pwp2p-containing subcomplex of 90S preribosome
namespace: cellular_component
def: "A protein complex that forms a subcomplex of the 90S preribosome and can interact directly with the 5' External Transcribed Spacer (ETS) of the full length pre-rRNA transcript. In S. cerevisiae, it sediments at 25-30 S and is composed of Pwp2p, Dip2p, Utp21p, Utp13p, Utp18p, and Utp6p." [GOC:krc, PMID:15231838]
comment: Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found.
synonym: "25-30 S subcomplex of 90S preribosome" EXACT []
synonym: "UTP-B complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044452 ! nucleolar part
relationship: part_of GO:0030686 ! 90S preribosome

[Term]
id: GO:0034389
name: lipid particle organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lipid particle." [GOC:dph, GOC:jl, GOC:mah, PMID:18093937, PMID:18250201]
synonym: "adiposome organization" EXACT []
synonym: "lipid body organization" EXACT []
synonym: "lipid droplet organization" EXACT []
synonym: "lipid particle organisation" EXACT [GOC:curators]
synonym: "lipid particle organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0034390
name: smooth muscle cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a smooth muscle cell. Smooth muscle consists of non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels." [CL:0000192, GOC:BHF, GOC:mah, GOC:mtg_apoptosis, GOC:rl]
synonym: "apoptosis of smooth muscle cells" EXACT []
synonym: "programmed cell death of smooth muscle cells by apoptosis" EXACT []
synonym: "programmed cell death, smooth muscle cells" EXACT []
synonym: "SMC apoptosis" EXACT []
synonym: "smooth muscle cell apoptosis" NARROW []
synonym: "smooth muscle cell programmed cell death by apoptosis" EXACT []
is_a: GO:0010657 ! muscle cell apoptotic process

[Term]
id: GO:0034391
name: regulation of smooth muscle cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of smooth muscle cell apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl]
synonym: "regulation of SMC apoptosis" EXACT []
synonym: "regulation of smooth muscle cell apoptosis" NARROW []
is_a: GO:0010660 ! regulation of muscle cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034390 ! smooth muscle cell apoptotic process
relationship: regulates GO:0034390 ! smooth muscle cell apoptotic process

[Term]
id: GO:0034392
name: negative regulation of smooth muscle cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl]
synonym: "down regulation of smooth muscle cell apoptosis" EXACT []
synonym: "down-regulation of smooth muscle cell apoptosis" EXACT []
synonym: "downregulation of smooth muscle cell apoptosis" EXACT []
synonym: "inhibition of smooth muscle cell apoptosis" NARROW []
synonym: "negative regulation of SMC apoptosis" EXACT []
synonym: "negative regulation of smooth muscle cell apoptosis" NARROW []
is_a: GO:0010656 ! negative regulation of muscle cell apoptotic process
is_a: GO:0034391 ! regulation of smooth muscle cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034390 ! smooth muscle cell apoptotic process
relationship: negatively_regulates GO:0034390 ! smooth muscle cell apoptotic process

[Term]
id: GO:0034393
name: positive regulation of smooth muscle cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of smooth muscle cell apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl]
synonym: "activation of smooth muscle cell apoptosis" NARROW []
synonym: "positive regulation of SMC apoptosis" EXACT []
synonym: "positive regulation of smooth muscle cell apoptosis" NARROW []
synonym: "stimulation of smooth muscle cell apoptosis" NARROW []
synonym: "up regulation of smooth muscle cell apoptosis" EXACT []
synonym: "up-regulation of smooth muscle cell apoptosis" EXACT []
synonym: "upregulation of smooth muscle cell apoptosis" EXACT []
is_a: GO:0010661 ! positive regulation of muscle cell apoptotic process
is_a: GO:0034391 ! regulation of smooth muscle cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034390 ! smooth muscle cell apoptotic process
relationship: positively_regulates GO:0034390 ! smooth muscle cell apoptotic process

[Term]
id: GO:0034394
name: protein localization to cell surface
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within the external part of the cell wall and/or plasma membrane." [GOC:mah]
synonym: "protein localisation at cell surface" EXACT [GOC:mah]
synonym: "protein localization at cell surface" EXACT [GOC:curators]
is_a: GO:0034613 ! cellular protein localization

[Term]
id: GO:0034395
name: regulation of transcription from RNA polymerase II promoter in response to iron
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to an iron stimulus." [GO_REF:0000021, GOC:mah]
comment: This term was added by GO_REF:0000021.
synonym: "regulation of specific transcription from RNA polymerase II promoter in response to iron" EXACT []
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
relationship: part_of GO:0071281 ! cellular response to iron ion

[Term]
id: GO:0034396
name: negative regulation of transcription from RNA polymerase II promoter in response to iron
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter in response to an iron stimulus." [GOC:mah]
synonym: "down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT []
synonym: "down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT []
synonym: "downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT []
synonym: "inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW []
synonym: "negative regulation of transcription from Pol II promoter in response to iron" EXACT []
is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
is_a: GO:0034395 ! regulation of transcription from RNA polymerase II promoter in response to iron

[Term]
id: GO:0034397
name: telomere localization
namespace: biological_process
def: "Any process in which a telomere is transported to, and/or maintained in, a specific location." [GOC:mah, GOC:vw]
synonym: "telomere localisation" EXACT [GOC:mah]
is_a: GO:0050000 ! chromosome localization

[Term]
id: GO:0034398
name: telomere tethering at nuclear periphery
namespace: biological_process
def: "The process in which a telomere is maintained in a specific location at the nuclear periphery." [GOC:mah]
is_a: GO:0034397 ! telomere localization

[Term]
id: GO:0034399
name: nuclear periphery
namespace: cellular_component
def: "The portion of the nuclear lumen proximal to the inner nuclear membrane." [GOC:krc, GOC:mah]
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0031981 ! nuclear lumen

[Term]
id: GO:0034400
name: gerontoplast
namespace: cellular_component
def: "A plastid found in senescing, formerly green tissues that is derived from a chloroplast that undergoes an organized developmental program of senescence." [PMID:12654863, PMID:16151876]
is_a: GO:0009536 ! plastid

[Term]
id: GO:0034401
name: chromatin organization involved in regulation of transcription
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin that modulates the rate, frequency or extent of DNA-dependent transcription." [GOC:curators]
subset: gocheck_do_not_manually_annotate
synonym: "establishment or maintenance of chromatin architecture during transcription" EXACT [GOC:mah]
synonym: "regulation of transcription by chromatin organisation" EXACT [GOC:mah]
synonym: "regulation of transcription by chromatin organization" EXACT []
is_a: GO:0006325 ! chromatin organization
intersection_of: GO:0006325 ! chromatin organization
intersection_of: part_of GO:0006355 ! regulation of transcription, DNA-templated
relationship: part_of GO:0006355 ! regulation of transcription, DNA-templated

[Term]
id: GO:0034402
name: recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex
namespace: biological_process
def: "The process in which proteins required for 3'-end transcript processing become associated with the RNA polymerase II holoenzyme complex and the 3' end of a transcript." [PMID:18195044]
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0031124 ! mRNA 3'-end processing

[Term]
id: GO:0034403
name: alignment of 3' and 5' splice sites of mRNA
namespace: biological_process
def: "Recognition of both the 5' and 3'-splice sites and positioning them in the correct alignment with respect to each other so that the second catalytic step of nuclear mRNA splicing can occur." [GOC:krc, PMID:9430647]
synonym: "alignment of 3' and 5' splice sites of nuclear mRNA" EXACT [GOC:vw]
is_a: GO:0000389 ! mRNA 3'-splice site recognition
is_a: GO:0000395 ! mRNA 5'-splice site recognition
relationship: part_of GO:0000350 ! generation of catalytic spliceosome for second transesterification step

[Term]
id: GO:0034404
name: nucleobase-containing small molecule biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide." [GOC:mah]
synonym: "nucleobase, nucleoside and nucleotide anabolism" EXACT []
synonym: "nucleobase, nucleoside and nucleotide biosynthesis" EXACT []
synonym: "nucleobase, nucleoside and nucleotide formation" EXACT []
synonym: "nucleobase, nucleoside and nucleotide synthesis" EXACT []
is_a: GO:0034654 ! nucleobase-containing compound biosynthetic process
is_a: GO:0044283 ! small molecule biosynthetic process
is_a: GO:0055086 ! nucleobase-containing small molecule metabolic process

[Term]
id: GO:0034405
name: response to fluid shear stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface." [GOC:sl]
is_a: GO:0006950 ! response to stress

[Term]
id: GO:0034406
name: cell wall beta-glucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of cells." [GOC:mah]
subset: gosubset_prok
synonym: "cell wall beta-glucan metabolism" EXACT []
is_a: GO:0010383 ! cell wall polysaccharide metabolic process
is_a: GO:0044723 ! single-organism carbohydrate metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0051273 ! beta-glucan metabolic process

[Term]
id: GO:0034407
name: cell wall (1->3)-beta-D-glucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in the walls of cells." [GOC:mah]
subset: gosubset_prok
synonym: "cell wall 1,3-beta-D-glucan metabolic process" EXACT []
synonym: "cell wall 1,3-beta-glucan metabolic process" BROAD []
synonym: "cell wall 1,3-beta-glucan metabolism" EXACT []
synonym: "cell wall beta-1,3 glucan metabolic process" EXACT []
synonym: "cell wall beta-1,3 glucan metabolism" EXACT []
is_a: GO:0006074 ! (1->3)-beta-D-glucan metabolic process
is_a: GO:0034406 ! cell wall beta-glucan metabolic process

[Term]
id: GO:0034408
name: ascospore wall beta-glucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of ascospores." [GOC:mah]
synonym: "ascospore wall beta-glucan metabolism" EXACT []
is_a: GO:0070879 ! fungal-type cell wall beta-glucan metabolic process
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0070591 ! ascospore wall biogenesis

[Term]
id: GO:0034409
name: ascospore wall (1->3)-beta-D-glucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in the walls of ascospores." [GOC:mah]
synonym: "ascospore wall 1,3-beta-D-glucan metabolic process" EXACT []
synonym: "ascospore wall 1,3-beta-glucan metabolic process" BROAD []
synonym: "ascospore wall 1,3-beta-glucan metabolism" EXACT [GOC:mah]
synonym: "ascospore wall beta-1,3 glucan metabolic process" EXACT [GOC:mah]
synonym: "ascospore wall beta-1,3 glucan metabolism" EXACT [GOC:mah]
is_a: GO:0034408 ! ascospore wall beta-glucan metabolic process
is_a: GO:0071969 ! fungal-type cell wall (1->3)-beta-D-glucan metabolic process

[Term]
id: GO:0034410
name: cell wall beta-glucan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of cells." [GOC:mah]
subset: gosubset_prok
synonym: "cell wall beta-glucan anabolism" EXACT []
synonym: "cell wall beta-glucan biosynthesis" EXACT []
synonym: "cell wall beta-glucan formation" EXACT []
synonym: "cell wall beta-glucan synthesis" EXACT []
is_a: GO:0034406 ! cell wall beta-glucan metabolic process
is_a: GO:0051274 ! beta-glucan biosynthetic process
is_a: GO:0070592 ! cell wall polysaccharide biosynthetic process

[Term]
id: GO:0034411
name: cell wall (1->3)-beta-D-glucan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in the walls of cells." [GOC:mah]
synonym: "cell wall 1,3-beta-D-glucan biosynthetic process" BROAD []
synonym: "cell wall 1,3-beta-glucan anabolism" EXACT []
synonym: "cell wall 1,3-beta-glucan biosynthesis" EXACT []
synonym: "cell wall 1,3-beta-glucan biosynthetic process" BROAD []
synonym: "cell wall 1,3-beta-glucan formation" EXACT []
synonym: "cell wall 1,3-beta-glucan synthesis" EXACT []
synonym: "cell wall beta-1,3-glucan anabolism" EXACT []
synonym: "cell wall beta-1,3-glucan biosynthesis" EXACT []
synonym: "cell wall beta-1,3-glucan biosynthetic process" EXACT []
synonym: "cell wall beta-1,3-glucan formation" EXACT []
synonym: "cell wall beta-1,3-glucan synthesis" EXACT []
is_a: GO:0006075 ! (1->3)-beta-D-glucan biosynthetic process
is_a: GO:0034407 ! cell wall (1->3)-beta-D-glucan metabolic process
is_a: GO:0034410 ! cell wall beta-glucan biosynthetic process
is_a: GO:0051278 ! fungal-type cell wall polysaccharide biosynthetic process

[Term]
id: GO:0034412
name: ascospore wall beta-glucan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of ascospores." [GOC:mah]
synonym: "ascospore wall beta-glucan anabolism" EXACT []
synonym: "ascospore wall beta-glucan biosynthesis" EXACT []
synonym: "ascospore wall beta-glucan formation" EXACT []
synonym: "ascospore wall beta-glucan synthesis" EXACT []
is_a: GO:0034408 ! ascospore wall beta-glucan metabolic process
is_a: GO:0070880 ! fungal-type cell wall beta-glucan biosynthetic process

[Term]
id: GO:0034413
name: ascospore wall (1->3)-beta-D-glucan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in the walls of ascospores." [GOC:mah]
synonym: "ascospore wall 1,3-beta-D-glucan biosynthetic process" BROAD []
synonym: "ascospore wall 1,3-beta-glucan anabolism" EXACT []
synonym: "ascospore wall 1,3-beta-glucan biosynthesis" EXACT []
synonym: "ascospore wall 1,3-beta-glucan biosynthetic process" BROAD []
synonym: "ascospore wall 1,3-beta-glucan formation" EXACT []
synonym: "ascospore wall 1,3-beta-glucan synthesis" EXACT []
synonym: "ascospore wall beta-1,3-glucan anabolism" EXACT []
synonym: "ascospore wall beta-1,3-glucan biosynthesis" EXACT []
synonym: "ascospore wall beta-1,3-glucan biosynthetic process" EXACT []
synonym: "ascospore wall beta-1,3-glucan formation" EXACT []
synonym: "ascospore wall beta-1,3-glucan synthesis" EXACT []
is_a: GO:0034409 ! ascospore wall (1->3)-beta-D-glucan metabolic process
is_a: GO:0034412 ! ascospore wall beta-glucan biosynthetic process
is_a: GO:0071970 ! fungal-type cell wall (1->3)-beta-D-glucan biosynthetic process

[Term]
id: GO:0034414
name: tRNA 3'-trailer cleavage, endonucleolytic
namespace: biological_process
def: "Endonucleolytic cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA." [GOC:mah]
synonym: "endonucleolytic tRNA 3'-end cleavage" EXACT []
synonym: "endonucleolytic tRNA 3'-trailer cleavage" RELATED []
synonym: "tRNA 3'-end cleavage, endonucleolytic" EXACT []
is_a: GO:0042779 ! tRNA 3'-trailer cleavage
is_a: GO:0090502 ! RNA phosphodiester bond hydrolysis, endonucleolytic

[Term]
id: GO:0034415
name: tRNA 3'-trailer cleavage, exonucleolytic
namespace: biological_process
def: "Exonucleolytic cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA." [GOC:mah]
synonym: "exonucleolytic tRNA 3'-end cleavage" EXACT []
synonym: "exonucleolytic tRNA 3'-trailer cleavage" EXACT []
synonym: "tRNA 3'-end cleavage, exonucleolytic" EXACT []
is_a: GO:0042779 ! tRNA 3'-trailer cleavage
is_a: GO:0090503 ! RNA phosphodiester bond hydrolysis, exonucleolytic

[Term]
id: GO:0034416
name: bisphosphoglycerate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-diphosphoglycerate + H2O = phosphoglycerate + phosphate." [EC:3.1.3.13, EC:3.1.3.80, GOC:mah, PMID:18413611]
synonym: "2,3-bisphosphoglycerate phosphatase activity" EXACT [EC:3.1.3.13]
synonym: "2,3-diphosphoglycerate phosphatase activity" EXACT [EC:3.1.3.13]
synonym: "2,3-diphosphoglyceric acid phosphatase activity" EXACT [EC:3.1.3.13]
synonym: "diphosphoglycerate phosphatase activity" EXACT [EC:3.1.3.13]
synonym: "glycerate-2,3-diphosphate phosphatase activity" EXACT [EC:3.1.3.13]
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0034417
name: bisphosphoglycerate 3-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-diphosphoglycerate + H2O = 2-phospho-D-glycerate + phosphate." [EC:3.1.3.80, GOC:mah, PMID:18413611]
synonym: "2,3-bisphospho-D-glycerate 3-phosphohydrolase activity" EXACT [EC:3.1.3.80]
xref: EC:3.1.3.80
xref: KEGG:R09532
xref: MetaCyc:RXN-11102
xref: RHEA:27384
is_a: GO:0034416 ! bisphosphoglycerate phosphatase activity

[Term]
id: GO:0034418
name: urate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of urate, the anion of uric acid, 2,6,8-trioxypurine." [GOC:mah]
synonym: "urate anabolism" RELATED []
synonym: "urate biosynthesis" EXACT []
synonym: "urate formation" EXACT []
synonym: "urate synthesis" EXACT []
synonym: "uric acid biosynthetic process" EXACT []
xref: Reactome:REACT_115590 "Urate synthesis, Gallus gallus"
is_a: GO:0044283 ! small molecule biosynthetic process
is_a: GO:0046415 ! urate metabolic process
is_a: GO:0072522 ! purine-containing compound biosynthetic process

[Term]
id: GO:0034419
name: L-2-hydroxyglutarate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-2-hydroxyglutarate + O2 = 2-oxoglutarate + hydrogen peroxide." [PMID:18390652]
is_a: GO:0003973 ! (S)-2-hydroxy-acid oxidase activity

[Term]
id: GO:0034420
name: co-translational protein acetylation
namespace: biological_process
def: "The addition of an acetyl group to one or more amino acids in a protein, occurring before the protein has been completely translated and released from the ribosome." [GOC:mah]
synonym: "co-translational protein amino acid acetylation" EXACT [GOC:bf]
synonym: "cotranslational protein amino acid acetylation" EXACT []
is_a: GO:0006473 ! protein acetylation
is_a: GO:0043686 ! co-translational protein modification

[Term]
id: GO:0034421
name: post-translational protein acetylation
namespace: biological_process
def: "The addition of an acetyl group to one or more amino acids in a protein, occurring after the protein has been completely translated and released from the ribosome." [GOC:mah]
synonym: "post-translational protein amino acid acetylation" EXACT [GOC:bf]
synonym: "posttranslational protein amino acid acetylation" EXACT []
is_a: GO:0006473 ! protein acetylation
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0034422
name: aleurone grain lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of an aleurone grain." [GOC:rph]
is_a: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen
relationship: part_of GO:0033095 ! aleurone grain

[Term]
id: GO:0034423
name: autophagosome lumen
namespace: cellular_component
def: "The volume enclosed within the autophagosome double-membrane." [GOC:autophagy, GOC:rph]
comment: Note that this term should be used for annotating gene products with caution: it should be used only to annotate gene products demonstrated to reside and function normally in the autophagic vacuole lumen, not for molecules that are temporarily found in the lumen prior to degradation.
synonym: "autophagic vacuole lumen" EXACT [GOC:autophagy]
is_a: GO:0005775 ! vacuolar lumen
relationship: part_of GO:0005776 ! autophagosome

[Term]
id: GO:0034424
name: Vps55/Vps68 complex
namespace: cellular_component
def: "A membrane-associated protein complex that is required for a late stage of endosomal transport. In budding yeast, this complex consists of Vps55p and Vps68p proteins." [PMID:18216282]
is_a: GO:0044440 ! endosomal part
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0010008 ! endosome membrane

[Term]
id: GO:0034425
name: etioplast envelope
namespace: cellular_component
def: "The double lipid bilayer enclosing the etioplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:mah]
is_a: GO:0009526 ! plastid envelope
relationship: part_of GO:0009513 ! etioplast

[Term]
id: GO:0034426
name: etioplast membrane
namespace: cellular_component
def: "Either of the lipid bilayers that surround a etioplast and form the etioplast envelope." [GOC:rph]
is_a: GO:0042170 ! plastid membrane
relationship: part_of GO:0034425 ! etioplast envelope

[Term]
id: GO:0034427
name: nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the mRNA transcript body that occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction." [GOC:krc, GOC:mah]
synonym: "3'-5' exonucleolytic nuclear-transcribed mRNA catabolic process" EXACT []
is_a: GO:0000291 ! nuclear-transcribed mRNA catabolic process, exonucleolytic

[Term]
id: GO:0034428
name: nuclear-transcribed mRNA catabolic process, exonucleolytic, 5'-3'
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the mRNA transcript body that occurs when the 5' end is not protected by a 5'-cap; degradation proceeds in the 5' to 3' direction." [GOC:krc, GOC:mah]
synonym: "5'-3' exonucleolytic nuclear-transcribed mRNA catabolic process" EXACT []
is_a: GO:0000291 ! nuclear-transcribed mRNA catabolic process, exonucleolytic

[Term]
id: GO:0034429
name: tectobulbar tract morphogenesis
namespace: biological_process
def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the optic tectum towards target cells in the premotor reticulospinal system in the hindbrain." [GOC:dsf, PMID:15065115, PMID:17507550, PMID:8038988]
is_a: GO:0021952 ! central nervous system projection neuron axonogenesis

[Term]
id: GO:0034430
name: monolayer-surrounded lipid storage body outer lipid monolayer
namespace: cellular_component
def: "The single layer of phopholipids surrounding a lipid storage body." [GOC:rph]
synonym: "lipid droplet outer lipid monolayer" RELATED []
synonym: "lipid storage body surface lipid monolayer" EXACT []
synonym: "oil body outer lipid monolayer" EXACT []
synonym: "oleosome outer lipid monolayer" EXACT []
synonym: "spherosome outer lipid monolayer" EXACT []
is_a: GO:0034646 ! organelle-enclosing lipid monolayer
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0012511 ! monolayer-surrounded lipid storage body

[Term]
id: GO:0034431
name: bis(5'-adenosyl)-hexaphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: P1-P6-bis(5'-adenosyl) hexaphosphate + H2O = AMP + adenosine 5'-pentaphosphate." [PMID:10085096, PMID:9450008]
synonym: "AP(6)A hydrolase activity" EXACT []
synonym: "AP-6-A hydrolase activity" EXACT []
synonym: "AP6A hydrolase activity" EXACT []
synonym: "diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase activity" EXACT []
is_a: GO:0004551 ! nucleotide diphosphatase activity

[Term]
id: GO:0034432
name: bis(5'-adenosyl)-pentaphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: P1-P6-bis(5'-adenosyl) pentaphosphate + H2O = AMP + adenosine 5'-tetraphosphate." [PMID:10085096, PMID:9450008]
synonym: "AP(5)A hydrolase activity" EXACT []
synonym: "AP-5-A hydrolase activity" EXACT []
synonym: "AP5A hydrolase activity" EXACT []
synonym: "Ap5a pyrophosphohydrolase activity" EXACT [GOC:tb]
synonym: "diadenosine 5',5'''-P1,P6-pentaphosphate hydrolase activity" EXACT []
is_a: GO:0004551 ! nucleotide diphosphatase activity

[Term]
id: GO:0034433
name: steroid esterification
namespace: biological_process
def: "A lipid modification process in which a steroid ester is formed by the combination of a carboxylic acid (often a fatty acid) and a steroid molecule (e.g. cholesterol)." [GOC:BHF, GOC:mah, GOC:pde, GOC:rl]
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:0030258 ! lipid modification

[Term]
id: GO:0034434
name: sterol esterification
namespace: biological_process
def: "A lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and a sterol molecule (e.g. cholesterol)." [GOC:BHF, GOC:mah, GOC:pde, GOC:rl]
is_a: GO:0034433 ! steroid esterification

[Term]
id: GO:0034435
name: cholesterol esterification
namespace: biological_process
def: "A lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and cholesterol. In the blood this process is associated with the conversion of free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle." [GOC:BHF, GOC:mah, GOC:pde, GOC:rl]
is_a: GO:0034434 ! sterol esterification

[Term]
id: GO:0034436
name: glycoprotein transport
namespace: biological_process
def: "The directed movement of a glycoprotein, any protein that contains covalently bound glycose (i.e. monosaccharide) residues, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:BHF, GOC:mah, GOC:rl]
is_a: GO:0015031 ! protein transport
is_a: GO:1901264 ! carbohydrate derivative transport

[Term]
id: GO:0034437
name: glycoprotein transporter activity
namespace: molecular_function
def: "Enables the directed movement of a glycoprotein, any protein that contains covalently bound glycose (i.e. monosaccharide) residues, into, out of or within a cell, or between cells." [GOC:BHF, GOC:mah, GOC:rl]
is_a: GO:0008565 ! protein transporter activity
is_a: GO:1901505 ! carbohydrate derivative transporter activity
relationship: part_of GO:0034436 ! glycoprotein transport

[Term]
id: GO:0034438
name: lipoprotein amino acid oxidation
namespace: biological_process
def: "The modification of a lipoprotein by oxidation of one or more amino acids in the protein." [GOC:BHF, GOC:mah]
subset: gosubset_prok
is_a: GO:0018158 ! protein oxidation
is_a: GO:0042161 ! lipoprotein oxidation

[Term]
id: GO:0034439
name: lipoprotein lipid oxidation
namespace: biological_process
def: "The modification of a lipoprotein by oxidation of the lipid group." [GOC:BHF, GOC:mah]
subset: gosubset_prok
is_a: GO:0034440 ! lipid oxidation
is_a: GO:0042161 ! lipoprotein oxidation

[Term]
id: GO:0034440
name: lipid oxidation
namespace: biological_process
def: "The removal of one or more electrons from a lipid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen." [GOC:BHF, GOC:mah]
is_a: GO:0030258 ! lipid modification
is_a: GO:0055114 ! oxidation-reduction process

[Term]
id: GO:0034441
name: plasma lipoprotein particle oxidation
namespace: biological_process
def: "The modification of a lipoprotein by oxidation of one or more amino acids or the lipid group, occurring in the blood plasma." [GOC:BHF, GOC:mah]
synonym: "plasma lipoprotein oxidation" EXACT [GOC:dph]
is_a: GO:0042161 ! lipoprotein oxidation

[Term]
id: GO:0034442
name: regulation of lipoprotein oxidation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lipoprotein oxidation." [GOC:BHF, GOC:mah]
is_a: GO:0050746 ! regulation of lipoprotein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042161 ! lipoprotein oxidation
relationship: regulates GO:0042161 ! lipoprotein oxidation

[Term]
id: GO:0034443
name: negative regulation of lipoprotein oxidation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lipoprotein oxidation." [GOC:BHF, GOC:mah]
synonym: "inhibition of lipoprotein oxidation" NARROW []
is_a: GO:0034442 ! regulation of lipoprotein oxidation
is_a: GO:0050748 ! negative regulation of lipoprotein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042161 ! lipoprotein oxidation
relationship: negatively_regulates GO:0042161 ! lipoprotein oxidation

[Term]
id: GO:0034444
name: regulation of plasma lipoprotein particle oxidation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lipoprotein oxidation, occurring in the blood plasma." [GOC:BHF, GOC:mah]
synonym: "regulation of plasma lipoprotein oxidation" EXACT [GOC:dph]
is_a: GO:0034442 ! regulation of lipoprotein oxidation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034441 ! plasma lipoprotein particle oxidation
relationship: regulates GO:0034441 ! plasma lipoprotein particle oxidation

[Term]
id: GO:0034445
name: negative regulation of plasma lipoprotein particle oxidation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lipoprotein particle oxidation, occurring in the blood plasma." [GOC:BHF, GOC:mah]
synonym: "inhibition of plasma lipoprotein oxidation" NARROW []
synonym: "negative regulation of plasma lipoprotein oxidation" EXACT [GOC:dph]
is_a: GO:0034443 ! negative regulation of lipoprotein oxidation
is_a: GO:0034444 ! regulation of plasma lipoprotein particle oxidation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034441 ! plasma lipoprotein particle oxidation
relationship: negatively_regulates GO:0034441 ! plasma lipoprotein particle oxidation

[Term]
id: GO:0034446
name: substrate adhesion-dependent cell spreading
namespace: biological_process
def: "The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate." [GOC:mah, GOC:pf, PMID:17050732]
synonym: "cell spreading during cell substrate adhesion" EXACT []
synonym: "substrate adhesion dependent cell spreading" EXACT []
is_a: GO:0000904 ! cell morphogenesis involved in differentiation
is_a: GO:0031589 ! cell-substrate adhesion
is_a: GO:0098602 ! single organism cell adhesion

[Term]
id: GO:0034447
name: very-low-density lipoprotein particle clearance
namespace: biological_process
def: "The process in which a very-low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:rl]
synonym: "VLDL clearance" EXACT []
is_a: GO:0034381 ! plasma lipoprotein particle clearance

[Term]
id: GO:0034448
name: EGO complex
namespace: cellular_component
alt_id: GO:0034449
def: "A vacuolar membrane-associated protein complex that is required for activation of microautophagy during exit from rapamycin-induced growth arrest. In budding yeast, S. cerevisiae, this complex includes Gtr1p, Gtr2p, Meh1p, and Slm4p." [GOC:dgf, GOC:rb, PMID:15989961, PMID:16732272, PMID:19748353]
synonym: "EGO-GSE complex" EXACT []
synonym: "GSE complex" EXACT []
synonym: "GTPase-containing complex for Gap1p sorting in the endosome" EXACT []
is_a: GO:0044440 ! endosomal part
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0005774 ! vacuolar membrane

[Term]
id: GO:0034450
name: ubiquitin-ubiquitin ligase activity
namespace: molecular_function
def: "Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin -> Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [GOC:mah, GOC:mcc, PMID:10089879, PMID:17190603]
synonym: "E4" EXACT []
xref: Reactome:REACT_24943 "Pellino ubiquitinates hp-IRAK1, Homo sapiens"
xref: Reactome:REACT_24976 "Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation<br>, Homo sapiens"
xref: Reactome:REACT_27265 "Activated TRAF6 synthesizes free K63 linked pUb chains., Gallus gallus"
xref: Reactome:REACT_75823 "TRAF3/or TRAF6 ubiquitination within dsRNA:MDA5:IPS1:TRAF3/TRAF6 complex, Gallus gallus"
xref: Reactome:REACT_75827 "ITCH homolog downregulates MDA5/IPS1 signaling, Gallus gallus"
xref: Reactome:REACT_75854 "TRAF6/or TRAF2 ubiquitination within dsRNA:Mda5:Ips1:Traf6/ or Traf2 complex, Gallus gallus"
is_a: GO:0061630 ! ubiquitin protein ligase activity

[Term]
id: GO:0034451
name: centriolar satellite
namespace: cellular_component
def: "A small (70-100 nm) cytoplasmic granule that contains a number of centrosomal proteins; centriolar satellites traffic toward microtubule minus ends and are enriched near the centrosome." [GOC:BHF, PMID:10579718, PMID:12403812]
is_a: GO:0044450 ! microtubule organizing center part
relationship: part_of GO:0005813 ! centrosome

[Term]
id: GO:0034452
name: dynactin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any part of a dynactin complex; dynactin is a large protein complex that activates dynein-based motor activity." [GOC:BHF, GOC:mah]
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0034453
name: microtubule anchoring
namespace: biological_process
def: "Any process in which a microtubule is maintained in a specific location in a cell." [GOC:mah]
is_a: GO:0000226 ! microtubule cytoskeleton organization

[Term]
id: GO:0034454
name: microtubule anchoring at centrosome
namespace: biological_process
def: "Any process in which a microtubule is maintained in a specific location in a cell by attachment to a centrosome." [GOC:BHF, GOC:mah]
is_a: GO:0072393 ! microtubule anchoring at microtubule organizing center

[Term]
id: GO:0034455
name: t-UTP complex
namespace: cellular_component
def: "A protein complex that forms a subcomplex of the 90S preribosome and is required for the subsequent assembly of the rest of the preribosome. In S. cerevisiae, it is composed of Utp5p, Utp4p, Nan1p, Utp8p, Utp9p, Utp10 and Utp15p." [GOC:krc, GOC:mah, GOC:vw, PMID:17515605]
comment: Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found.
synonym: "Nan1p-containing subcomplex of 90S preribosome" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044452 ! nucleolar part

[Term]
id: GO:0034456
name: UTP-C complex
namespace: cellular_component
def: "A protein complex that forms a subcomplex of the 90S preribosome. In S. cerevisiae, it is composed of Rrp7p, Utp22p, Ckb1p, Cka1p, Ckb2p and Cka2p." [GOC:mah, PMID:17515605]
comment: Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found.
synonym: "Rrp7p-containing subcomplex of 90S preribosome" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044452 ! nucleolar part
relationship: part_of GO:0030686 ! 90S preribosome

[Term]
id: GO:0034457
name: Mpp10 complex
namespace: cellular_component
def: "A protein complex that forms a subcomplex of the 90S preribosome. In S. cerevisiae, it is composed of Mpp10p, Imp3p and Imp4p." [GOC:mah, PMID:17515605]
comment: Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found.
is_a: GO:0043234 ! protein complex
is_a: GO:0044452 ! nucleolar part
relationship: part_of GO:0030686 ! 90S preribosome

[Term]
id: GO:0034458
name: 3'-5' RNA helicase activity
namespace: molecular_function
def: "Catalysis of the unwinding of an RNA helix in the direction 3' to 5'." [GOC:mah]
synonym: "3' to 5' RNA helicase activity" EXACT []
is_a: GO:0003724 ! RNA helicase activity

[Term]
id: GO:0034459
name: ATP-dependent 3'-5' RNA helicase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix in the direction 3' to 5'." [GOC:jp]
synonym: "ATP-dependent 3' to 5' RNA helicase activity" EXACT []
is_a: GO:0004004 ! ATP-dependent RNA helicase activity
is_a: GO:0034458 ! 3'-5' RNA helicase activity

[Term]
id: GO:0034460
name: uropod assembly
namespace: biological_process
def: "The assembly of a uropod by rearrangement of the cytoskeleton and overlying membrane." [GOC:mah]
synonym: "uropod formation" EXACT [GOC:mah]
is_a: GO:0030031 ! cell projection assembly
is_a: GO:0032796 ! uropod organization

[Term]
id: GO:0034461
name: uropod retraction
namespace: biological_process
def: "The process in which a uropod detaches from the cell substrate and retracts the rear of a migrating cell." [GOC:mah, PMID:10704379]
is_a: GO:0032796 ! uropod organization

[Term]
id: GO:0034462
name: small-subunit processome assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a small-subunit processome." [GOC:mah]
synonym: "small subunit processome assembly" EXACT []
synonym: "SSU processome assembly" EXACT []
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0000028 ! ribosomal small subunit assembly

[Term]
id: GO:0034463
name: 90S preribosome assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a 90S preribosome. The 90S preribosome represents the complex that forms on the primary rRNA transcript before it splits into the small subunit and large subunit portions." [GOC:krc, GOC:mah, GOC:tb]
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0000027 ! ribosomal large subunit assembly
relationship: part_of GO:0000028 ! ribosomal small subunit assembly

[Term]
id: GO:0034464
name: BBSome
namespace: cellular_component
def: "A protein complex that associates with the primary cilium and is involved in cilium biogenesis; consists of seven conserved proteins: BBS1, BBS2, BBS4, BBS5, BBS7, BBS8 and BBS9." [GOC:BHF, PMID:17574030]
synonym: "Bardet-Biedl syndrome complex" EXACT []
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0034465
name: response to carbon monoxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon monoxide (CO) stimulus." [GOC:ecd]
is_a: GO:0010033 ! response to organic substance
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0034466
name: chromaffin granule lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of a chromaffin granule." [GOC:rph]
is_a: GO:0034774 ! secretory granule lumen
relationship: part_of GO:0042583 ! chromaffin granule

[Term]
id: GO:0034467
name: esterosome lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of an esterosome." [GOC:rph]
is_a: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen
relationship: part_of GO:0033117 ! esterosome

[Term]
id: GO:0034468
name: glycosome lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of a glycosome." [GOC:rph]
is_a: GO:0005782 ! peroxisomal matrix
relationship: part_of GO:0020015 ! glycosome

[Term]
id: GO:0034469
name: Golgi stack lumen
namespace: cellular_component
def: "The volume enclosed by any of the membranes of the thin, flattened cisternae that form the central portion of the Golgi complex." [GOC:mah]
is_a: GO:0005796 ! Golgi lumen
relationship: part_of GO:0005795 ! Golgi stack

[Term]
id: GO:0034470
name: ncRNA processing
namespace: biological_process
def: "Any process that results in the conversion of one or more primary non-coding RNA (ncRNA) transcripts into one or more mature ncRNA molecules." [GOC:mah]
is_a: GO:0006396 ! RNA processing
is_a: GO:0034660 ! ncRNA metabolic process

[Term]
id: GO:0034471
name: ncRNA 5'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 5' end of a non-coding RNA molecule." [GOC:mah]
synonym: "ncRNA 5' end processing" EXACT []
is_a: GO:0000966 ! RNA 5'-end processing
is_a: GO:0034470 ! ncRNA processing

[Term]
id: GO:0034472
name: snRNA 3'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 3' end of an snRNA molecule." [GOC:mah]
synonym: "snRNA 3' end processing" EXACT []
is_a: GO:0016180 ! snRNA processing
is_a: GO:0043628 ! ncRNA 3'-end processing

[Term]
id: GO:0034473
name: U1 snRNA 3'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 3' end of a U1 snRNA molecule." [GOC:mah]
synonym: "U1 snRNA 3' end processing" EXACT []
is_a: GO:0034472 ! snRNA 3'-end processing

[Term]
id: GO:0034474
name: U2 snRNA 3'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 3' end of a U2 snRNA molecule." [GOC:mah]
synonym: "U2 snRNA 3' end processing" EXACT []
is_a: GO:0034472 ! snRNA 3'-end processing

[Term]
id: GO:0034475
name: U4 snRNA 3'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 3' end of a U4 snRNA molecule." [GOC:mah]
synonym: "U4 snRNA 3' end processing" EXACT []
is_a: GO:0034472 ! snRNA 3'-end processing

[Term]
id: GO:0034476
name: U5 snRNA 3'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 3' end of a U5 snRNA molecule." [GOC:mah]
synonym: "U5 snRNA 3' end processing" EXACT []
is_a: GO:0034472 ! snRNA 3'-end processing

[Term]
id: GO:0034477
name: U6 snRNA 3'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 3' end of a U6 snRNA molecule." [GOC:mah]
synonym: "U6 snRNA 3' end processing" EXACT []
is_a: GO:0034472 ! snRNA 3'-end processing

[Term]
id: GO:0034478
name: phosphatidylglycerol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phosphatidylglycerols, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol." [GOC:mah]
subset: gosubset_prok
synonym: "phosphatidylglycerol breakdown" EXACT []
synonym: "phosphatidylglycerol catabolism" EXACT []
synonym: "phosphatidylglycerol degradation" EXACT []
is_a: GO:0046471 ! phosphatidylglycerol metabolic process
is_a: GO:0046475 ! glycerophospholipid catabolic process

[Term]
id: GO:0034479
name: phosphatidylglycerol phospholipase C activity
namespace: molecular_function
def: "Catalysis of the reaction: a phosphatidylglycerol + H2O = 1,2-diacylglycerol + glycerol 3-phosphate." [GOC:mah, PMID:18434318]
is_a: GO:0004629 ! phospholipase C activity

[Term]
id: GO:0034480
name: phosphatidylcholine phospholipase C activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphatidylcholine + H2O = 1,2-diacylglycerol + a choline phosphate." [EC:3.1.4.3, GOC:mah]
subset: gosubset_prok
synonym: "alpha-toxin" NARROW [EC:3.1.4.3]
synonym: "Clostridium oedematiens beta- and gamma-toxins activity" NARROW [EC:3.1.4.3]
synonym: "Clostridium welchii alpha-toxin activity" NARROW [EC:3.1.4.3]
synonym: "heat-labile hemolysin" NARROW [EC:3.1.4.3]
synonym: "lipophosphodiesterase I activity" EXACT [EC:3.1.4.3]
synonym: "phosphatidylcholine cholinephosphohydrolase activity" EXACT [EC:3.1.4.3]
synonym: "phospholipase C, acting on phosphatidylcholine" EXACT []
xref: EC:3.1.4.3
xref: MetaCyc:PHOSPHOLIPASE-C-RXN
xref: RHEA:10607
is_a: GO:0004629 ! phospholipase C activity

[Term]
id: GO:0034481
name: chondroitin sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin sulfate." [EC:2.8.2.17, EC:2.8.2.5, GOC:mah]
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0034482
name: chondroitin 2-O-sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 2'-O-sulfate. Results in sulfation of glucuronic acid and iduronic acid residues." [PMID:17227754]
synonym: "chondroitin 2-O-sulphotransferase activity" EXACT []
synonym: "chondroitin 2-sulfotransferase activity" EXACT []
is_a: GO:0034481 ! chondroitin sulfotransferase activity

[Term]
id: GO:0034483
name: heparan sulfate sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + sulfated heparan sulfate." [GOC:mah]
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0034484
name: raffinose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of raffinose, the trisaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [CHEBI:16634, GOC:mah]
synonym: "raffinose breakdown" EXACT []
synonym: "raffinose catabolism" EXACT []
synonym: "raffinose degradation" EXACT []
is_a: GO:0009313 ! oligosaccharide catabolic process
is_a: GO:0033530 ! raffinose metabolic process

[Term]
id: GO:0034485
name: phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidylinositol-3,4-bisphosphate + phosphate." [GOC:pf]
xref: MetaCyc:RXN-10036
is_a: GO:0034594 ! phosphatidylinositol trisphosphate phosphatase activity
is_a: GO:0034595 ! phosphatidylinositol phosphate 5-phosphatase activity

[Term]
id: GO:0034486
name: vacuolar transmembrane transport
namespace: biological_process
def: "The process in which a solute is transported from one side of the vacuolar membrane to the other." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "vacuolar membrane transport" EXACT []
is_a: GO:0007034 ! vacuolar transport
is_a: GO:0055085 ! transmembrane transport

[Term]
id: GO:0034487
name: vacuolar amino acid transmembrane transport
namespace: biological_process
def: "The process in which an amino acid is transported from one side of the vacuolar membrane to the other." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "vacuolar amino acid membrane transport" EXACT []
is_a: GO:0003333 ! amino acid transmembrane transport
is_a: GO:0034486 ! vacuolar transmembrane transport

[Term]
id: GO:0034488
name: basic amino acid transmembrane export from vacuole
namespace: biological_process
def: "The directed movement of basic amino acids out of the vacuole, across the vacuolar membrane." [GOC:mah]
is_a: GO:0015802 ! basic amino acid transport
is_a: GO:0032974 ! amino acid transmembrane export from vacuole

[Term]
id: GO:0034489
name: neutral amino acid transmembrane export from vacuole
namespace: biological_process
def: "The directed movement of neutral amino acids out of the vacuole, across the vacuolar membrane." [GOC:mah]
is_a: GO:0015804 ! neutral amino acid transport
is_a: GO:0032974 ! amino acid transmembrane export from vacuole

[Term]
id: GO:0034490
name: basic amino acid transmembrane import into vacuole
namespace: biological_process
def: "The directed movement of basic amino acids into the vacuole across the vacuolar membrane." [GOC:mah]
is_a: GO:0015802 ! basic amino acid transport
is_a: GO:0032975 ! amino acid transmembrane import into vacuole

[Term]
id: GO:0034491
name: neutral amino acid transmembrane import into vacuole
namespace: biological_process
def: "The directed movement of neutral amino acids into the vacuole across the vacuolar membrane." [GOC:mah]
is_a: GO:0015804 ! neutral amino acid transport
is_a: GO:0032975 ! amino acid transmembrane import into vacuole

[Term]
id: GO:0034492
name: hydrogenosome lumen
namespace: cellular_component
def: "The volume enclosed by the hydrogenosome membrane." [GOC:rph]
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0070013 ! intracellular organelle lumen
relationship: part_of GO:0042566 ! hydrogenosome

[Term]
id: GO:0034493
name: melanosome lumen
namespace: cellular_component
def: "The volume enclosed by the melanosome membrane." [GOC:rph]
is_a: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen
relationship: part_of GO:0042470 ! melanosome

[Term]
id: GO:0034494
name: microneme lumen
namespace: cellular_component
def: "The volume enclosed by the microneme membrane." [GOC:rph]
is_a: GO:0070013 ! intracellular organelle lumen
relationship: part_of GO:0020009 ! microneme

[Term]
id: GO:0034495
name: protein storage vacuole lumen
namespace: cellular_component
def: "The volume enclosed by the protein storage vacuole membrane." [GOC:rph]
is_a: GO:0000330 ! plant-type vacuole lumen
relationship: part_of GO:0000326 ! protein storage vacuole

[Term]
id: GO:0034496
name: multivesicular body membrane disassembly
namespace: biological_process
def: "The controlled breakdown of the membranes of multivesicular bodies." [GOC:rb]
synonym: "MVB membrane disassembly" EXACT []
is_a: GO:0030397 ! membrane disassembly
relationship: part_of GO:0036257 ! multivesicular body organization

[Term]
id: GO:0034497
name: protein localization to pre-autophagosomal structure
namespace: biological_process
def: "Any process in which a protein is transported to, or maintained at, the pre-autophagosomal structure (PAS)." [GOC:rb]
synonym: "protein localisation to pre-autophagosomal structure" EXACT [GOC:mah]
synonym: "protein localization to PAS" EXACT []
is_a: GO:0034613 ! cellular protein localization
relationship: part_of GO:0000045 ! autophagosome assembly

[Term]
id: GO:0034498
name: early endosome to Golgi transport
namespace: biological_process
def: "The directed movement of substances from early endosomes to the Golgi." [GOC:rb]
synonym: "PGE to Golgi transport" EXACT []
synonym: "post-Golgi endosome to Golgi transport" EXACT []
is_a: GO:0042147 ! retrograde transport, endosome to Golgi
is_a: GO:0048193 ! Golgi vesicle transport

[Term]
id: GO:0034499
name: late endosome to Golgi transport
namespace: biological_process
def: "The directed movement of substances from late endosomes to the Golgi." [GOC:rb]
synonym: "prevacuolar endosome to Golgi transport" EXACT []
synonym: "PVE to Golgi transport" EXACT []
is_a: GO:0042147 ! retrograde transport, endosome to Golgi
is_a: GO:0048193 ! Golgi vesicle transport
relationship: occurs_in GO:0005737 ! cytoplasm

[Term]
id: GO:0034501
name: protein localization to kinetochore
namespace: biological_process
def: "Any process in which a protein is transported to, or maintained at, the kinetochore." [GOC:mah]
synonym: "condensin localization to kinetochore" NARROW []
synonym: "protein localisation to kinetochore" EXACT [GOC:mah]
is_a: GO:0071459 ! protein localization to chromosome, centromeric region

[Term]
id: GO:0034502
name: protein localization to chromosome
namespace: biological_process
def: "Any process in which a protein is transported to, or maintained at, a specific location on a chromosome." [GOC:mah]
synonym: "condensin localization to chromosome" NARROW []
synonym: "protein localisation to chromosome" EXACT [GOC:mah]
is_a: GO:0033365 ! protein localization to organelle

[Term]
id: GO:0034503
name: protein localization to nucleolar rDNA repeats
namespace: biological_process
def: "Any process in which a protein is transported to, or maintained at, the rDNA repeats on a chromosome in the nucleolus." [GOC:mah]
synonym: "condensin localization to nucleolar rDNA repeats" NARROW []
synonym: "protein localisation to nucleolar rDNA repeats" EXACT [GOC:mah]
is_a: GO:0034502 ! protein localization to chromosome
relationship: part_of GO:0007000 ! nucleolus organization

[Term]
id: GO:0034504
name: protein localization to nucleus
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within the nucleus." [GOC:ecd]
synonym: "protein localisation to nucleus" EXACT [GOC:mah]
synonym: "protein localization in cell nucleus" EXACT []
synonym: "protein localization in nucleus" EXACT [GOC:mah]
is_a: GO:0033365 ! protein localization to organelle

[Term]
id: GO:0034505
name: tooth mineralization
namespace: biological_process
def: "The process in which calcium salts are deposited into calcareous tooth structures such as dental enamel, dentin and cementum." [GOC:mah, MP:0002817, MSH:D014074]
synonym: "tooth calcification" EXACT []
is_a: GO:0031214 ! biomineral tissue development
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0042476 ! odontogenesis

[Term]
id: GO:0034506
name: chromosome, centromeric core domain
namespace: cellular_component
def: "The innermost portion of the centromeric region of a chromosome, encompassing the core region of a chromosome centromere and the proteins that bind to it." [GOC:mah, GOC:vw]
synonym: "chromosome, centric core region" RELATED []
synonym: "chromosome, centromeric core region" EXACT [GOC:vw]
is_a: GO:0098687 ! chromosomal region
relationship: part_of GO:0000775 ! chromosome, centromeric region

[Term]
id: GO:0034507
name: chromosome, centromeric outer repeat region
namespace: cellular_component
def: "The portion of the centromeric region of a chromosome that flanks the core region, encompassing repeated regions of a chromosome centromere and the proteins that bind to it." [GOC:mah, GOC:vw]
synonym: "chromosome, centric outer repeat region" RELATED []
is_a: GO:0098687 ! chromosomal region
relationship: part_of GO:0000775 ! chromosome, centromeric region

[Term]
id: GO:0034508
name: centromere complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins and centromeric DNA molecules to form a centromeric protein-DNA complex. Includes the formation of the chromatin structures which form a platform for the kinetochore, and assembly of the kinetochore onto this specialized chromatin. In fission yeast and higher eukaryotes this process also includes the formation of heterochromatin at the outer repeat (pericentric) regions of the centromere." [GOC:mah, GOC:vw]
synonym: "centromere assembly" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "centromere organization" EXACT [GOC:dph, PMID:18923422]
synonym: "chromosome, centromeric region assembly" EXACT [GOC:pr]
is_a: GO:0051276 ! chromosome organization
is_a: GO:0065004 ! protein-DNA complex assembly

[Term]
id: GO:0034510
name: centromere separation
namespace: biological_process
def: "The cell cycle process in which centromeres are physically detached from each other during chromosome separation." [GOC:mah]
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0051304 ! chromosome separation
relationship: part_of GO:0098813 ! nuclear chromosome segregation

[Term]
id: GO:0034511
name: U3 snoRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with U3 small nucleolar RNA." [GOC:mah]
is_a: GO:0030515 ! snoRNA binding

[Term]
id: GO:0034512
name: box C/D snoRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with box C/D small nucleolar RNA." [GOC:mah]
is_a: GO:0030515 ! snoRNA binding

[Term]
id: GO:0034513
name: box H/ACA snoRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with box H/ACA small nucleolar RNA." [GOC:mah]
is_a: GO:0030515 ! snoRNA binding

[Term]
id: GO:0034514
name: mitochondrial unfolded protein response
namespace: biological_process
def: "The series of molecular signals generated as a consequence of the presence of unfolded proteins in the mitochondrial matrix; results in transcriptional upregulation of nuclear genes encoding mitochondrial stress proteins." [GOC:mah, PMID:17849004]
synonym: "mtUPR" EXACT []
is_a: GO:0034620 ! cellular response to unfolded protein

[Term]
id: GO:0034515
name: proteasome storage granule
namespace: cellular_component
def: "A multisubunit proteasome complex that localizes in the cytoplasm as dot-like structures when cells are in a quiescent state." [GOC:rb, PMID:18504300]
synonym: "PSG" EXACT []
is_a: GO:0031597 ! cytosolic proteasome complex

[Term]
id: GO:0034516
name: response to vitamin B6
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B6 stimulus. Vitamin B6 encompasses pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate." [GOC:mah, GOC:rph]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033273 ! response to vitamin

[Term]
id: GO:0034517
name: ribophagy
namespace: biological_process
def: "The process in which cells degrade mature ribosomes under conditions of starvation." [GOC:autophagy, PMID:18391941]
is_a: GO:0016236 ! macroautophagy

[Term]
id: GO:0034518
name: RNA cap binding complex
namespace: cellular_component
def: "Any protein complex that binds to a specialized RNA cap structure at any time in the lifetime of the RNA." [GOC:mah]
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0034519
name: cytoplasmic RNA cap binding complex
namespace: cellular_component
def: "A protein complex found in the cytoplasm that binds the 5' cap structure of an mRNA, and typically consists of the cap-binding protein eIF4E, the adaptor protein eIF4G, and a multi-factor complex comprising eIF1, eIF2, eIF3 and eIF5. This complex mediates recruitment of the 40S subunit to mRNA." [PMID:16405910]
is_a: GO:0005845 ! mRNA cap binding complex
is_a: GO:0044445 ! cytosolic part
relationship: part_of GO:0005829 ! cytosol

[Term]
id: GO:0034520
name: 2-naphthaldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-naphthaldehyde + NAD+ + H2O = 2-naphthoate + NADH + H+." [UM-BBD_reactionID:r0772]
xref: EC:1.2.1.-
xref: UM-BBD_reactionID:r0772
is_a: GO:0004029 ! aldehyde dehydrogenase (NAD) activity

[Term]
id: GO:0034521
name: 1-naphthoic acid dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-naphthoic acid + NADH + O2 + H+ = cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene + NAD+." [UM-BBD_reactionID:r0773]
xref: EC:1.14.12.-
xref: UM-BBD_reactionID:r0773
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0034522
name: cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene = 1,2-dihydroxy-8-carboxynaphthalene + 2 H+ + 2 e-." [UM-BBD_reactionID:r0774]
xref: EC:1.1.-.-
xref: UM-BBD_reactionID:r0774
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0034523
name: 3-formylsalicylate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-formylsalicylic acid + O2 + H2O = 2-hydroxyisophthalic acid + hydrogen peroxide." [UM-BBD_reactionID:r0777]
xref: EC:1.2.3.-
xref: UM-BBD_reactionID:r0777
is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor

[Term]
id: GO:0034524
name: 2-hydroxyisophthalate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxyisophthalic acid = salicylate + CO2." [UM-BBD_reactionID:r0776]
xref: EC:4.1.1.-
xref: UM-BBD_reactionID:r0776
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0034525
name: 1-naphthaldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-naphthaldehyde + NAD+ + H2O = 1-naphthoic acid + NADH + H+." [UM-BBD_reactionID:r0787]
xref: EC:1.2.1.-
xref: UM-BBD_reactionID:r0787
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0034526
name: 2-methylnaphthalene hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-methylnaphthalene + NADH + O2 + H+ = 2-hydroxymethylnaphthalene + NAD+ + H2O." [UM-BBD_reactionID:r0788]
xref: EC:1.14.13.-
xref: UM-BBD_reactionID:r0788
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0034527
name: 1,2-dihydroxy-8-carboxynaphthalene dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-dihydroxy-8-carboxynaphthalene + O2 = 2-carboxy-2-hydroxy-8-carboxychromene." [UM-BBD_reactionID:r0790]
xref: EC:1.13.-.-
xref: UM-BBD_reactionID:r0790
is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen

[Term]
id: GO:0034528
name: 2-carboxy-2-hydroxy-8-carboxychromene isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-carboxy-2-hydroxy-8-carboxychromene = 2-hydroxy-3-carboxybenzalpyruvate." [UM-BBD_reactionID:r0791]
xref: EC:5.3.99.-
xref: UM-BBD_reactionID:r0791
is_a: GO:0016860 ! intramolecular oxidoreductase activity

[Term]
id: GO:0034529
name: 2-hydroxy-3-carboxy-benzalpyruvate hydratase-aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxy-3-carboxybenzalpyruvate + H2O = 3-formylsalicylic acid + pyruvate." [UM-BBD_reactionID:r0792]
xref: EC:4.1.2.-
xref: UM-BBD_reactionID:r0792
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0034530
name: 4-hydroxymethylsalicyaldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxymethylsalicylaldehyde + NAD+ + H2O = 4-hydroxymethylsalicylate + NADH + 2 H+." [UM-BBD_reactionID:r0767]
xref: EC:1.2.1.-
xref: UM-BBD_reactionID:r0767
is_a: GO:0004029 ! aldehyde dehydrogenase (NAD) activity

[Term]
id: GO:0034531
name: 2-hydroxy-4-hydroxymethylbenzalpyruvate hydratase-aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxy-4-hydroxymethylbenzalpyruvate + H2O = pyruvate + 4-hydroxymethylsalicylaldehyde." [UM-BBD_reactionID:r0766]
xref: EC:4.1.2.-
xref: UM-BBD_reactionID:r0766
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0034532
name: 2-hydroxy-7-hydroxymethylchromene-2-carboxylate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxy-7-hydroxymethylchromene-2-carboxylate = 2-hydroxy-4-hydroxymethylbenzalpyruvate." [UM-BBD_reactionID:r0765]
xref: EC:5.3.99.-
xref: UM-BBD_reactionID:r0765
is_a: GO:0016860 ! intramolecular oxidoreductase activity

[Term]
id: GO:0034533
name: 1,2-dihydroxy-7-hydroxymethylnaphthalene dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-dihydroxy-7-hydroxymethylnaphthalene + O2 = 2-hydroxy-7-hydroxymethylchromene-2-carboxylate." [UM-BBD_reactionID:r0764]
xref: EC:1.13.-.-
xref: UM-BBD_reactionID:r0764
is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen

[Term]
id: GO:0034534
name: 1-methylnaphthalene hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-methylnaphthalene + NADH + H+ + O2 = 1-hydroxymethylnaphthalene + NAD+ + H2O." [UM-BBD_reactionID:r0795]
xref: EC:1.14.13.-
xref: UM-BBD_reactionID:r0795
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0034535
name: 1,2-dihydroxy-8-methylnaphthalene dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-dihydroxy-8-methylnaphthalene + O2 = 2-hydroxy-8-methylchromene-2-carboxylate + H+." [UM-BBD_reactionID:r0781]
xref: EC:1.13.-.-
xref: UM-BBD_reactionID:r0781
is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen

[Term]
id: GO:0034536
name: 2-hydroxy-8-methylchromene-2-carboxylate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxy-8-methylchromene-2-carboxylate = 2-hydroxy-3-methylbenzalpyruvate." [UM-BBD_reactionID:r0782]
xref: EC:5.3.99.-
xref: UM-BBD_reactionID:r0782
is_a: GO:0016860 ! intramolecular oxidoreductase activity

[Term]
id: GO:0034537
name: 2-hydroxy-3-methylbenzalpyruvate hydratase-aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxy-3-methylbenzalpyruvate + H2O = pyruvate + 3-methylsalicylaldehyde." [UM-BBD_reactionID:r0783]
xref: EC:4.1.2.-
xref: UM-BBD_reactionID:r0783
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0034538
name: 3-methylsalicylaldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-methylsalicylaldehyde + NAD+ = 3-methylsalicylate + NADH + H+." [UM-BBD_reactionID:r0784]
xref: EC:1.2.1.-
xref: UM-BBD_reactionID:r0784
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0034539
name: 3,3',5,5'-tetrabromobisphenol A reductive dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,3',5,5'-tetrabromobisphenol A + 2 H+ + 2 e- = 3,3',5-tribromobisphenol A + HBr." [UM-BBD_reactionID:r0821]
xref: EC:1.97.1.-
xref: UM-BBD_reactionID:r0821
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0034540
name: 3-monobromobisphenol A reductive dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-monobromobisphenol A + 2 H+ + 2 e- = bisphenol A + HBr." [UM-BBD_reactionID:r0824]
xref: EC:1.97.1.-
xref: UM-BBD_reactionID:r0824
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0034541
name: dimethylarsinite methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: dimethylarsenous acid + R2S-CH3 = trimethylarsine oxide + R2SH." [UM-BBD_reactionID:r0806]
xref: EC:2.1.1.-
xref: UM-BBD_reactionID:r0806
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0034542
name: trimethylarsine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: trimethylarsine oxide + 2 H+ + 2 e- = trimethylarsine + H2O." [UM-BBD_reactionID:r0807]
xref: EC:1.97.1.-
xref: UM-BBD_reactionID:r0807
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0034543
name: 5-aminosalicylate dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-aminosalicylate + O2 = cis-4-amino-6-carboxy-2-oxo-hexa-3,5-dienoate." [UM-BBD_reactionID:r0809]
xref: EC:1.13.11.-
xref: UM-BBD_reactionID:r0809
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0034544
name: trans-ACOHDA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-4-amino-6-carboxy-2-oxo-hexa-3,5-dienoate + H2O = fumarylpyruvate + NH3." [UM-BBD_reactionID:r0810]
xref: EC:3.5.99.-
xref: UM-BBD_reactionID:r0810
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

[Term]
id: GO:0034545
name: fumarylpyruvate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: fumarylpyruvate + H2O = fumarate + pyruvate + H+." [UM-BBD_reactionID:r0811]
xref: EC:3.7.1.-
xref: UM-BBD_reactionID:r0811
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0034546
name: 2,4-dichloroaniline reductive dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4-dichloroaniline + 2 H+ + 2 e- = 4-chloroaniline + HCl." [UM-BBD_reactionID:r0819]
xref: EC:1.97.1.-
xref: UM-BBD_reactionID:r0819
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0034547
name: N-cyclopropylmelamine deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyromazine + H2O = N-cyclopropylammeline + NH3." [UM-BBD_reactionID:r0825]
xref: EC:3.5.4.-
xref: MetaCyc:RXN-8018
xref: UM-BBD_reactionID:r0825
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines

[Term]
id: GO:0034548
name: N-cyclopropylammeline deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-cyclopropylammeline + H2O = N-cyclopropylammelide + NH3." [UM-BBD_reactionID:r0826]
xref: EC:3.5.4.-
xref: MetaCyc:RXN-8019
xref: UM-BBD_reactionID:r0826
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines

[Term]
id: GO:0034549
name: N-cyclopropylammelide alkylamino hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-cyclopropylammelide + H2O = cyclopropylamine + cyanuric acid." [UM-BBD_reactionID:r0827]
xref: EC:3.5.4.-
xref: MetaCyc:RXN-8020
xref: UM-BBD_reactionID:r0827
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines

[Term]
id: GO:0034550
name: dimethylarsinate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: dimethylarsinate + 3 H+ + 2 e- = dimethylarsinous acid + H2O." [UM-BBD_reactionID:r0838]
xref: EC:1.97.1.-
xref: UM-BBD_reactionID:r0838
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0034551
name: mitochondrial respiratory chain complex III assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the cytochrome bc(1) complex (also known as ubiquinol-cytochrome c reductase), in the mitochondrial inner membrane." [GOC:dgf, GOC:mcc]
synonym: "mitochondrial cytochrome bc(1) complex assembly" EXACT [GOC:mcc]
is_a: GO:0017062 ! respiratory chain complex III assembly
is_a: GO:0033108 ! mitochondrial respiratory chain complex assembly
is_a: GO:0097033 ! mitochondrial respiratory chain complex III biogenesis
intersection_of: GO:0017062 ! respiratory chain complex III assembly
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion

[Term]
id: GO:0034552
name: respiratory chain complex II assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex II." [GOC:dgf]
is_a: GO:0043623 ! cellular protein complex assembly

[Term]
id: GO:0034553
name: mitochondrial respiratory chain complex II assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex II, in the mitochondrial inner membrane." [GOC:dgf]
is_a: GO:0033108 ! mitochondrial respiratory chain complex assembly
is_a: GO:0034552 ! respiratory chain complex II assembly
is_a: GO:0097032 ! mitochondrial respiratory chain complex II biogenesis
intersection_of: GO:0034552 ! respiratory chain complex II assembly
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion

[Term]
id: GO:0034554
name: 3,3',5-tribromobisphenol A reductive dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,3',5-tribromobisphenol A + 2 H+ + 2 e- = 3,3'-dibromobisphenol A + HBr." [UM-BBD_reactionID:r0842]
xref: EC:1.97.1.-
xref: UM-BBD_reactionID:r0842
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0034555
name: 3,3'-dibromobisphenol A reductive dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,3'-dibromobisphenol A + 2 H+ + 2 e- = 3-monobromobisphenol A + HBr." [UM-BBD_reactionID:r0844]
xref: EC:1.97.1.-
xref: UM-BBD_reactionID:r0844
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0034556
name: nitrobenzoate nitroreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: o-nitrobenzoate + NADPH + H+ = o-hydroxylaminobenzoate + NADP+." [UM-BBD_reactionID:r0849]
xref: EC:1.7.1.-
xref: UM-BBD_reactionID:r0849
is_a: GO:0016657 ! oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor

[Term]
id: GO:0034557
name: 2-hydroxylaminobenzoate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxylaminobenzoate + NAD(P)H = anthranilate + NAD(P)+ + H2O." [MetaCyc:RXN-8848]
synonym: "o-hydroxylaminobenzoate nitroreductase activity" RELATED [UM-BBD_reactionID:r0850]
xref: EC:1.4.-.-
xref: MetaCyc:RXN-8848
xref: UM-BBD_reactionID:r0850
is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors

[Term]
id: GO:0034558
name: technetium (VII) reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: pertechnetate ion + 3/2 H2 = technetium (IV) oxide + H2O + OH-." [UM-BBD_reactionID:r0859]
xref: EC:1.12.-.-
xref: UM-BBD_reactionID:r0859
is_a: GO:0016695 ! oxidoreductase activity, acting on hydrogen as donor

[Term]
id: GO:0034559
name: bisphenol A hydroxylase B activity
namespace: molecular_function
def: "Catalysis of the reaction: bisphenol A + NADH + H+ + O2 = 1,2-bis(4-hydroxyphenyl)-2-propanol + NAD+ + H2O." [UM-BBD_reactionID:r0860]
xref: EC:1.14.-.-
xref: UM-BBD_reactionID:r0860
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0034560
name: bisphenol A hydroxylase A activity
namespace: molecular_function
def: "Catalysis of the reaction: bisphenol A + NADH + H+ + O2 = 2,2-bis(4-hydroxyphenyl)-1-propanol + NAD+ + H2O." [UM-BBD_reactionID:r0861]
xref: EC:1.14.13.-
xref: UM-BBD_reactionID:r0861
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0034561
name: 1,2-bis(4-hydroxyphenyl)-2-proponol dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-bis(4-hydroxyphenyl)-2-propanol = 4,4'-dihydroxy-alpha-methylstilbene + H2O." [UM-BBD_reactionID:r0862]
xref: EC:4.2.1.-
xref: UM-BBD_reactionID:r0862
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0034562
name: 2,2-bis(4-hydroxyphenyl)-1-propanol hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,2-bis(4-hydroxyphenyl)-1-propanol + NADH + H+ + O2 = 2,3-bis(4-hydroxyphenyl)-1,2-propanediol + NAD+ + H2O." [UM-BBD_reactionID:r0864]
xref: EC:1.14.-.-
xref: UM-BBD_reactionID:r0864
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0034563
name: 2,3-bis(4-hydroxyphenyl)-1,2-propanediol dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-bis(4-hydroxyphenyl)-1,2-propanediol + O2 = 4-hydroxyphenacyl alcohol + 4-hydroxybenzoate + 2 H+ + 2 e-." [UM-BBD_reactionID:r0867]
xref: EC:1.13.-.-
xref: UM-BBD_reactionID:r0867
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0034564
name: 4,4'-dihydroxy-alpha-methylstilbene dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4,4'-dihydroxy-alpha-methylstilbene + O2 = 4-hydroxybenzaldehyde + 4-hydroxyacetophenone + 2 H+ + 2 e-." [UM-BBD_reactionID:r0866]
xref: EC:1.3.-.-
xref: UM-BBD_reactionID:r0866
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0034565
name: 1-nitro-1,2-dihydro-1,3,5-triazine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-nitro-1,2-dihydro-1,3,5-triazine + 2 H2O = 1-nitro-1,3,5-triazinane-2,4-diol." [UM-BBD_reactionID:r0872]
xref: EC:3.5.99.-
xref: UM-BBD_reactionID:r0872
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

[Term]
id: GO:0034567
name: chromate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: chromate = chromium (III)." [UM-BBD_reactionID:r0884]
xref: EC:1.97.1.-
xref: UM-BBD_reactionID:r0884
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0034568
name: isoproturon dimethylaminedehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: isoproturon + H2O = formaldehyde + monodemethylisoproturon + 2 H+ + 2 e-." [UM-BBD_reactionID:r0892]
xref: EC:1.5.99.-
xref: UM-BBD_reactionID:r0892
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0034569
name: monodemethylisoproturon dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: monodemethylisoproturon + H2O = hydroxymonodemethylisoproturon + 2 H+ + 2 e-." [UM-BBD_reactionID:r0893]
xref: EC:1.17.99.-
xref: UM-BBD_reactionID:r0893
is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups

[Term]
id: GO:0034570
name: hydroxymonomethylisoproturon dimethylaminedehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydroxymonodemethylisoproturon + H2O = formaldehyde + 4'-(2-hydroxyisopropyl)phenylurea + 2 H+ + 2 e-." [UM-BBD_reactionID:r0894]
xref: EC:1.5.99.-
xref: UM-BBD_reactionID:r0894
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0034571
name: 4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4'-(2-hydroxyisopropyl)phenylurea + H2O = 4'-(2-hydroxyisopropyl)phenylaniline + carbamic acid." [UM-BBD_reactionID:r0895]
xref: EC:3.5.1.-
xref: UM-BBD_reactionID:r0895
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0034572
name: monodemethylisoproturon dimethylaminedehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: monodemethylisoproturon + H2O = didemethylisoproturon + formaldehyde + 2 H+ + 2 e-." [UM-BBD_reactionID:r0897]
xref: EC:1.5.99.-
xref: UM-BBD_reactionID:r0897
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0034573
name: didemethylisoproturon amidohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: didemethylisoproturon + H2O = carbamic acid + 4-isopropylaniline." [UM-BBD_reactionID:r0898]
xref: EC:3.5.1.-
xref: UM-BBD_reactionID:r0898
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0034574
name: didemethylisoproturon dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: didemethylisoproturon + H2O = 4'-(2-hydroxyisopropyl)phenylurea + 2 H+ + 2 e-." [UM-BBD_reactionID:r0899]
xref: EC:1.17.99.-
xref: UM-BBD_reactionID:r0899
is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups

[Term]
id: GO:0034575
name: 4-isopropylaniline dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-isopropylaniline + H2O = 4'-(2-hydroxyisopropyl)phenylaniline + 2 H+ + 2 e-." [UM-BBD_reactionID:r0901]
xref: EC:1.17.99.-
xref: UM-BBD_reactionID:r0901
is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups

[Term]
id: GO:0034576
name: N-isopropylacetanilide amidohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-isopropylacetanilide + OH- = N-isopropylaniline + acetate." [UM-BBD_reactionID:r0913]
xref: EC:3.5.1.-
xref: UM-BBD_reactionID:r0913
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0034577
name: N-isopropylacetaniline monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-isopropylacetanilide + 1/2 O2 = acetanilide + acetone." [UM-BBD_reactionID:r0914]
xref: EC:1.14.15.-
xref: UM-BBD_reactionID:r0914
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0034578
name: limonene 8-hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: limonene + H2O = alpha-terpineol." [UM-BBD_reactionID:r0916]
xref: EC:4.2.1.-
xref: UM-BBD_reactionID:r0916
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0034579
name: (1-methylpentyl)succinate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: fumarate + n-hexane = (1-methylpentyl)succinate." [UM-BBD_reactionID:r0920]
xref: EC:4.1.99.-
xref: UM-BBD_reactionID:r0920
is_a: GO:0016830 ! carbon-carbon lyase activity

[Term]
id: GO:0034580
name: 4-methyloctanoyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-methyloctanoyl-CoA = 4-methyloct-2-enoyl-CoA + 2 H+ + 2 e-." [UM-BBD_reactionID:r0924]
xref: EC:1.3.99.-
xref: UM-BBD_reactionID:r0924
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0034581
name: 4-methyloct-2-enoyl-CoA hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-methyloct-2-enoyl-CoA + H2O = 3-hydroxy-4-methyloctanoyl-CoA." [UM-BBD_reactionID:r0925]
xref: EC:4.2.1.-
xref: UM-BBD_reactionID:r0925
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0034582
name: 3-hydroxy-4-methyloctanoyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxy-4-methyloctanoyl-CoA = 4-methyl-3-oxooctanoyl-CoA + 2 H+ + 2 e-." [UM-BBD_reactionID:r0926]
xref: EC:1.1.-.-
xref: UM-BBD_reactionID:r0926
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0034583
name: 21U-RNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a 21U-RNA, a 21-nucleotide RNA characterized by a uridine 5'-monophosphate and a modified 3' end resistant to periodate degradation. 21U-RNAs are derived from distinct, autonomously expressed loci within the genome." [GOC:kmv]
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0034584
name: piRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a piRNA, a Piwi-associated RNA, a 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism." [GOC:kmv]
synonym: "Piwi-associated RNA binding" EXACT []
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0034585
name: 21U-RNA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 21U-RNAs, a class of single-stranded RNA molecules of about 21 nucleotides in length characterized by a uridine 5'-monophosphate and a modified 3' end resistant to periodate degradation. 21U-RNAs are derived from distinct, autonomously expressed loci within the genome." [GOC:kmv]
synonym: "21U-RNA metabolism" EXACT []
is_a: GO:0034660 ! ncRNA metabolic process

[Term]
id: GO:0034586
name: 21U-RNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 21U-RNAs, a class of single-stranded RNA molecules of about 21 nucleotides in length characterized by a uridine 5'-monophosphate and a modified 3' end resistant to periodate degradation. 21U-RNAs are derived from distinct, autonomously expressed loci within the genome." [GOC:kmv]
synonym: "21U-RNA breakdown" EXACT []
synonym: "21U-RNA catabolism" EXACT []
synonym: "21U-RNA degradation" EXACT []
is_a: GO:0034585 ! 21U-RNA metabolic process
is_a: GO:0034661 ! ncRNA catabolic process

[Term]
id: GO:0034587
name: piRNA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism." [GOC:kmv]
synonym: "piRNA metabolism" EXACT []
synonym: "Piwi-associated RNA metabolic process" EXACT []
is_a: GO:0034660 ! ncRNA metabolic process

[Term]
id: GO:0034588
name: piRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism." [GOC:kmv]
synonym: "piRNA breakdown" EXACT []
synonym: "piRNA catabolism" EXACT []
synonym: "piRNA degradation" EXACT []
synonym: "Piwi-associated RNA catabolic process" EXACT []
is_a: GO:0034587 ! piRNA metabolic process
is_a: GO:0034661 ! ncRNA catabolic process

[Term]
id: GO:0034589
name: hydroxyproline transport
namespace: biological_process
def: "The directed movement of hydroxyproline into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah, PMID:14502423]
synonym: "4-hydroxyproline transport" EXACT []
synonym: "L-hydroxyproline transport" NARROW []
is_a: GO:0006865 ! amino acid transport
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0072337 ! modified amino acid transport

[Term]
id: GO:0034590
name: L-hydroxyproline transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of L-hydroxyproline from one side of a membrane to the other." [GOC:mah, PMID:14502423]
synonym: "4-hydroxyproline transmembrane transporter activity" BROAD []
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity
is_a: GO:0072349 ! modified amino acid transmembrane transporter activity
relationship: part_of GO:0034589 ! hydroxyproline transport

[Term]
id: GO:0034591
name: rhoptry lumen
namespace: cellular_component
def: "The volume enclosed by the rhoptry membrane." [GOC:rph, PMID:17997128]
is_a: GO:0043233 ! organelle lumen
is_a: GO:0044464 ! cell part
relationship: part_of GO:0020008 ! rhoptry

[Term]
id: GO:0034592
name: synaptic vesicle lumen
namespace: cellular_component
def: "The volume enclosed by the synaptic vesicle membrane." [GOC:rph]
subset: goslim_synapse
is_a: GO:0044456 ! synapse part
is_a: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen
is_a: GO:0097458 ! neuron part
intersection_of: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen
intersection_of: part_of GO:0008021 ! synaptic vesicle
relationship: part_of GO:0008021 ! synaptic vesicle

[Term]
id: GO:0034593
name: phosphatidylinositol bisphosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphatidylinositol bisphosphate + H2O = phosphatidylinositol phosphate + phosphate." [GOC:mah]
synonym: "diphosphoinositide phosphatase activity" RELATED []
synonym: "phosphatidyl-inositol-bisphosphate phosphatase activity" EXACT []
synonym: "phosphatidylinositol-bisphosphatase activity" RELATED []
synonym: "triphosphoinositide phosphatase activity" RELATED []
synonym: "triphosphoinositide phosphomonoesterase activity" RELATED []
is_a: GO:0052866 ! phosphatidylinositol phosphate phosphatase activity

[Term]
id: GO:0034594
name: phosphatidylinositol trisphosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphatidylinositol trisphosphate + H2O = phosphatidylinositol bisphosphate + phosphate." [GOC:mah]
is_a: GO:0052866 ! phosphatidylinositol phosphate phosphatase activity

[Term]
id: GO:0034595
name: phosphatidylinositol phosphate 5-phosphatase activity
namespace: molecular_function
def: "Catalysis of the removal of the 5-phosphate group of a phosphatidylinositol phosphate." [GOC:elh]
subset: gosubset_prok
synonym: "phosphoinositide 5-phosphatase activity" EXACT [GOC:curators]
synonym: "polyphosphoinositol lipid 5-phosphatase activity" EXACT []
is_a: GO:0052866 ! phosphatidylinositol phosphate phosphatase activity

[Term]
id: GO:0034596
name: phosphatidylinositol phosphate 4-phosphatase activity
namespace: molecular_function
def: "Catalysis of the removal of the 4-phosphate group of a phosphatidylinositol phosphate." [GOC:mah]
synonym: "inositol 4-phosphatase" NARROW [GOC:rl]
synonym: "phosphoinositide 4-phosphatase activity" EXACT [GOC:curators]
synonym: "PI(4)P-phosphatase activity" EXACT [GOC:rl]
synonym: "PI4P-phosphatase activity" EXACT [GOC:rl]
synonym: "PtdIns4P-phosphatase activity" EXACT [GOC:rl]
is_a: GO:0052866 ! phosphatidylinositol phosphate phosphatase activity

[Term]
id: GO:0034597
name: phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-phosphatidyl-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate." [GOC:mah]
synonym: "1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase activity" EXACT []
synonym: "inositol polyphosphate 4-phosphatase type II activity" RELATED [EC:3.1.3.66]
synonym: "phosphatidyl-myo-inositol-4,5-bisphosphate 4-phosphohydrolase activity" EXACT []
xref: EC:3.1.3.66
xref: MetaCyc:3.1.3.66-RXN
is_a: GO:0034593 ! phosphatidylinositol bisphosphate phosphatase activity
is_a: GO:0034596 ! phosphatidylinositol phosphate 4-phosphatase activity

[Term]
id: GO:0034598
name: phosphothreonine lyase activity
namespace: molecular_function
def: "Catalysis of the removal of the phosphate group from phosphothreonine by cleavage of the C-OP bond with the concomitant abstraction of the alpha proton, generating a double bond-containing product." [PMID:17303758, PMID:18084305]
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0034599
name: cellular response to oxidative stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah]
synonym: "adaptive response to oxidative stress" NARROW [GOC:add, GOC:vk]
is_a: GO:0006979 ! response to oxidative stress
is_a: GO:0033554 ! cellular response to stress
is_a: GO:0070887 ! cellular response to chemical stimulus

[Term]
id: GO:0034601
name: oxoglutarate dehydrogenase [NAD(P)+] activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + CoA + NAD(P)+ = succinyl-CoA + CO2 + NAD(P)H." [GOC:mah]
xref: EC:1.2.1.-
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0034602
name: oxoglutarate dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + CoA + NAD+ = succinyl-CoA + CO2 + NADH." [GOC:mah]
xref: EC:1.2.1.-
xref: KEGG:R08549
xref: MetaCyc:2OXOGLUTARATEDEH-RXN
xref: Reactome:REACT_100909 "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+, Staphylococcus aureus N315"
xref: Reactome:REACT_104005 "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+, Plasmodium falciparum"
xref: Reactome:REACT_104161 "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+, Sus scrofa"
xref: Reactome:REACT_108749 "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+, Plasmodium falciparum"
xref: Reactome:REACT_108886 "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+, Taeniopygia guttata"
xref: Reactome:REACT_109973 "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+, Gallus gallus"
xref: Reactome:REACT_110604 "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+, Rattus norvegicus"
xref: Reactome:REACT_110822 "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+, Danio rerio"
xref: Reactome:REACT_112439 "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+, Escherichia coli"
xref: Reactome:REACT_113722 "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+, Oryza sativa"
xref: Reactome:REACT_114766 "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+, Oryza sativa"
xref: Reactome:REACT_115236 "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+, Arabidopsis thaliana"
xref: Reactome:REACT_115335 "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+, Escherichia coli"
xref: Reactome:REACT_115419 "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+, Arabidopsis thaliana"
xref: Reactome:REACT_115716 "2-oxoglutarate (alpha-ketoglutarate) + CoASH + NAD+ => succinylCoA + CO2 + NADH + H+, Gallus gallus"
xref: Reactome:REACT_1865 "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+, Homo sapiens"
xref: Reactome:REACT_28665 "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+, Rattus norvegicus"
xref: Reactome:REACT_30875 "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+, Saccharomyces cerevisiae"
xref: Reactome:REACT_33446 "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+, Bos taurus"
xref: Reactome:REACT_34092 "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+, Xenopus tropicalis"
xref: Reactome:REACT_64827 "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+, Schizosaccharomyces pombe"
xref: Reactome:REACT_66 "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+, Homo sapiens"
xref: Reactome:REACT_78311 "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+, Bos taurus"
xref: Reactome:REACT_78897 "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+, Mus musculus"
xref: Reactome:REACT_80433 "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+, Canis familiaris"
xref: Reactome:REACT_83427 "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+, Sus scrofa"
xref: Reactome:REACT_84105 "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+, Mus musculus"
xref: Reactome:REACT_86487 "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+, Canis familiaris"
xref: Reactome:REACT_89083 "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+, Dictyostelium discoideum"
xref: Reactome:REACT_89734 "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+, Danio rerio"
xref: Reactome:REACT_89895 "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+, Drosophila melanogaster"
xref: Reactome:REACT_91421 "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+, Drosophila melanogaster"
xref: Reactome:REACT_93348 "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+, Staphylococcus aureus N315"
xref: Reactome:REACT_95016 "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+, Dictyostelium discoideum"
xref: Reactome:REACT_95363 "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+, Taeniopygia guttata"
xref: Reactome:REACT_97909 "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+, Saccharomyces cerevisiae"
xref: Reactome:REACT_99546 "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+, Gallus gallus"
xref: Reactome:REACT_99666 "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+, Xenopus tropicalis"
xref: Reactome:REACT_99678 "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+, Schizosaccharomyces pombe"
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0034603
name: pyruvate dehydrogenase [NAD(P)+] activity
namespace: molecular_function
def: "Catalysis of the reaction: pyruvate + CoA + NAD(P)+ = acetyl-CoA + CO2 + NAD(P)H." [GOC:mah]
xref: EC:1.2.1.-
is_a: GO:0004738 ! pyruvate dehydrogenase activity
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0034604
name: pyruvate dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: pyruvate + CoA + NAD+ = acetyl-CoA + CO2 + NADH." [GOC:mah, ISBN:0201090910]
xref: EC:1.2.1.-
xref: KEGG:R00209
xref: MetaCyc:PYRUVDEH-RXN
xref: Reactome:REACT_115563 "pyruvate + CoASH + NAD+ => acetylCoA + CO2 + NADH + H+, Gallus gallus"
is_a: GO:0034603 ! pyruvate dehydrogenase [NAD(P)+] activity
relationship: has_part GO:0004148 ! dihydrolipoyl dehydrogenase activity
relationship: has_part GO:0004739 ! pyruvate dehydrogenase (acetyl-transferring) activity
relationship: has_part GO:0004742 ! dihydrolipoyllysine-residue acetyltransferase activity
relationship: part_of GO:0006086 ! acetyl-CoA biosynthetic process from pyruvate

[Term]
id: GO:0034605
name: cellular response to heat
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:mah]
synonym: "cellular response to heat stress" EXACT []
is_a: GO:0009408 ! response to heat
is_a: GO:0033554 ! cellular response to stress

[Term]
id: GO:0034606
name: response to hermaphrodite contact
namespace: biological_process
def: "The response by the male to a hermaphrodite after initial contact following mate finding. The male stops forward locomotion, presses the ventral side of his tail against his partner's body, and begins moving backward along the hermaphrodite. Male response behavior is initiated when sensory neurons located in the rays of his tail contact a potential mate." [PMID:18050467, WB_REF:WBPaper00002109]
is_a: GO:0060179 ! male mating behavior

[Term]
id: GO:0034607
name: turning behavior involved in mating
namespace: biological_process
def: "The sharp ventral turn performed by the male as he approaches either the hermaphrodite head or tail, whilst trying to locate his partner's vulva. Turning occurs via a sharp ventral coil of the male's tail." [PMID:18050467, WB_REF:WBPaper00002109]
synonym: "turning behavior during mating" EXACT []
is_a: GO:0035178 ! turning behavior
is_a: GO:0060179 ! male mating behavior
intersection_of: GO:0035178 ! turning behavior
intersection_of: part_of GO:0007618 ! mating
relationship: part_of GO:0007618 ! mating

[Term]
id: GO:0034608
name: vulval location
namespace: biological_process
def: "Location, by the male, of his partner's vulva when backing along the ventral side of the hermaphrodite during mating. The male stops at the vulva, coordinates his movements to the hermaphrodite's, and positions his tail precisely over the vulva so that he may insert his spicules and ejaculate." [PMID:18050467]
is_a: GO:0060179 ! male mating behavior

[Term]
id: GO:0034609
name: spicule insertion
namespace: biological_process
def: "Insertion of the male copulatory spicules into the hermaphrodite. Spicule insertion behavior initiates when the male cloaca contacts the vulva. During most mating encounters, the spicule tips will prod the vulva continuously until they partially penetrate, which then causes the protractors to contract completely so that the spicules extend through the vulva." [PMID:18050467]
is_a: GO:0060179 ! male mating behavior

[Term]
id: GO:0034610
name: oligodeoxyribonucleotidase activity
namespace: molecular_function
def: "Catalysis of the exonucleolytic cleavage of oligodeoxyribonucleotides to yield deoxyribonucleoside 5'-phosphates." [GOC:mah]
synonym: "DNA oligonucleotidase activity" EXACT []
is_a: GO:0004536 ! deoxyribonuclease activity
is_a: GO:0008946 ! oligonucleotidase activity

[Term]
id: GO:0034611
name: oligoribonucleotidase activity
namespace: molecular_function
def: "Catalysis of the exonucleolytic cleavage of oligoribonucleotides to yield ribonucleoside 5'-phosphates." [GOC:mah]
synonym: "RNA oligonucleotidase activity" EXACT []
is_a: GO:0004540 ! ribonuclease activity
is_a: GO:0008946 ! oligonucleotidase activity

[Term]
id: GO:0034612
name: response to tumor necrosis factor
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus." [GOC:mah]
synonym: "response to TNF" EXACT []
is_a: GO:0034097 ! response to cytokine

[Term]
id: GO:0034613
name: cellular protein localization
namespace: biological_process
alt_id: GO:0016249
def: "Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah]
synonym: "cellular protein localisation" EXACT [GOC:mah]
synonym: "channel localizer activity" NARROW [GOC:mah]
is_a: GO:0008104 ! protein localization
is_a: GO:0070727 ! cellular macromolecule localization

[Term]
id: GO:0034614
name: cellular response to reactive oxygen species
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:mah]
subset: gosubset_prok
synonym: "cellular response to active oxygen species" EXACT []
synonym: "cellular response to AOS" EXACT []
synonym: "cellular response to reactive oxidative species" EXACT []
synonym: "cellular response to reactive oxygen intermediate" EXACT []
synonym: "cellular response to ROI" EXACT []
synonym: "cellular response to ROS" EXACT []
is_a: GO:0000302 ! response to reactive oxygen species
is_a: GO:0034599 ! cellular response to oxidative stress
is_a: GO:1901701 ! cellular response to oxygen-containing compound

[Term]
id: GO:0034615
name: GCH1 complex
namespace: cellular_component
def: "A protein complex that possesses GTP cyclohydrolase I activity. In E. coli and human, the complex is a homodecamer, and monomers are catalytically inactive." [PMID:16696853]
synonym: "GTP cyclohydrolase I complex" EXACT []
is_a: GO:0044424 ! intracellular part
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0034616
name: response to laminar fluid shear stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a laminar fluid shear stress stimulus. Laminar fluid flow is the force acting on an object in a system where the fluid is moving across a solid surface in parallel layers. As an example, laminar shear stress can be seen where blood flows against the luminal side of blood vessel walls." [GOC:ecd]
is_a: GO:0034405 ! response to fluid shear stress

[Term]
id: GO:0034617
name: tetrahydrobiopterin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a tetrahydrobiopterin, 5,6,7,8-tetrahydrobiopterin or a derivative thereof; tetrahydrobiopterins are enzyme cofactors that carry electrons in redox reactions." [CHEBI:15372, GOC:BHF, GOC:mah, GOC:rl]
synonym: "BH4 binding" EXACT []
synonym: "H4biopterin binding" EXACT []
synonym: "sapropterin binding" EXACT []
is_a: GO:0050662 ! coenzyme binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding

[Term]
id: GO:0034618
name: arginine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with 2-amino-5-(carbamimidamido)pentanoic acid." [CHEBI:29016, GOC:BHF, GOC:rl]
synonym: "aminopentanoic acid binding" RELATED []
synonym: "Arg binding" EXACT []
is_a: GO:0016597 ! amino acid binding
is_a: GO:0043169 ! cation binding

[Term]
id: GO:0034620
name: cellular response to unfolded protein
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus." [GOC:mah]
comment: Note that this term should not be confused with 'unfolded protein response ; GO:0030968', which refers to the signaling pathways that respond to the presence of unfolded proteins in the ER.
subset: gosubset_prok
synonym: "heat shock protein activity" RELATED []
is_a: GO:0006986 ! response to unfolded protein
is_a: GO:0035967 ! cellular response to topologically incorrect protein

[Term]
id: GO:0034622
name: cellular macromolecular complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of macromolecules to form a complex, carried out at the cellular level." [GOC:mah]
subset: goslim_pir
subset: gosubset_prok
synonym: "cellular macromolecule complex assembly" EXACT []
is_a: GO:0065003 ! macromolecular complex assembly

[Term]
id: GO:0034624
name: DNA recombinase assembly involved in gene conversion at mating-type locus
namespace: biological_process
def: "The aggregation, arrangement and bonding together of strand exchange proteins (recombinases) into higher order oligomers on single-stranded DNA, involved in the conversion of the mating-type locus from one allele to another." [GOC:mah]
is_a: GO:0000730 ! DNA recombinase assembly
is_a: GO:0022414 ! reproductive process
intersection_of: GO:0000730 ! DNA recombinase assembly
intersection_of: part_of GO:0007534 ! gene conversion at mating-type locus
relationship: part_of GO:0007534 ! gene conversion at mating-type locus

[Term]
id: GO:0034625
name: fatty acid elongation, monounsaturated fatty acid
namespace: biological_process
def: "Elongation of a fatty acid chain into which one C-C double bond has been introduced." [GOC:mah]
subset: gosubset_prok
is_a: GO:0019368 ! fatty acid elongation, unsaturated fatty acid

[Term]
id: GO:0034626
name: fatty acid elongation, polyunsaturated fatty acid
namespace: biological_process
def: "Elongation of a fatty acid chain into which two or more C-C double bonds have been introduced." [GOC:mah]
subset: gosubset_prok
is_a: GO:0019368 ! fatty acid elongation, unsaturated fatty acid

[Term]
id: GO:0034627
name: 'de novo' NAD biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD), beginning with the synthesis of tryptophan or aspartate from simpler precursors; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:imk, PMID:17161604]
synonym: "de novo NAD biosynthetic process" RELATED []
is_a: GO:0009435 ! NAD biosynthetic process

[Term]
id: GO:0034628
name: 'de novo' NAD biosynthetic process from aspartate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD), beginning with the synthesis of aspartate from simpler precursors; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:imk]
synonym: "de novo NAD biosynthetic process from aspartate" RELATED []
is_a: GO:0019355 ! nicotinamide nucleotide biosynthetic process from aspartate
is_a: GO:0034627 ! 'de novo' NAD biosynthetic process

[Term]
id: GO:0034629
name: cellular protein complex localization
namespace: biological_process
def: "A protein complex localization process that takes place at the cellular level; as a result, a protein complex is transported to, or maintained in, a specific location within a cell." [GOC:mah]
synonym: "cellular protein complex localisation" EXACT [GOC:mah]
synonym: "establishment and maintenance of cellular protein complex localization" EXACT []
is_a: GO:0031503 ! protein complex localization
is_a: GO:0034613 ! cellular protein localization

[Term]
id: GO:0034630
name: RITS complex localization
namespace: biological_process
def: "Any process in which a RITS complex is transported to, or maintained in, a specific location." [GOC:mah]
synonym: "establishment and maintenance of RITS complex localization" EXACT []
synonym: "RITS complex localisation" EXACT [GOC:mah]
is_a: GO:0034629 ! cellular protein complex localization

[Term]
id: GO:0034631
name: microtubule anchoring at spindle pole body
namespace: biological_process
def: "Any process in which a microtubule is maintained in a specific location in a cell by attachment to a spindle pole body. Microtubules attach to spindle pole bodies at the minus end." [GOC:mah, PMID:17486116]
synonym: "attachment of spindle microtubules to SPB" EXACT []
synonym: "attachment of spindle microtubules to spindle pole body" EXACT []
synonym: "microtubule anchoring at SPB" EXACT []
is_a: GO:0022402 ! cell cycle process
is_a: GO:0072393 ! microtubule anchoring at microtubule organizing center
relationship: part_of GO:0007051 ! spindle organization

[Term]
id: GO:0034632
name: retinol transporter activity
namespace: molecular_function
def: "Enables the directed movement of retinol into, out of or within a cell, or between cells. Retinol is vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A." [GOC:BHF, GOC:mah, GOC:vk]
synonym: "vitamin A1 transporter activity" EXACT []
is_a: GO:0005319 ! lipid transporter activity
is_a: GO:0051183 ! vitamin transporter activity
relationship: part_of GO:0034633 ! retinol transport

[Term]
id: GO:0034633
name: retinol transport
namespace: biological_process
def: "The directed movement of retinol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Retinol is vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A." [GOC:BHF, GOC:mah, GOC:vk]
synonym: "vitamin A1 transport" EXACT []
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0046865 ! terpenoid transport

[Term]
id: GO:0034634
name: glutathione transmembrane transporter activity
namespace: molecular_function
def: "Enables the directed movement of glutathione, the tripeptide glutamylcysteinylglycine, across a membrane into, out of or within a cell, or between cells." [GOC:mah]
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0035673 ! oligopeptide transmembrane transporter activity
is_a: GO:0042937 ! tripeptide transporter activity
is_a: GO:0072349 ! modified amino acid transmembrane transporter activity
is_a: GO:1901682 ! sulfur compound transmembrane transporter activity
relationship: part_of GO:0034775 ! glutathione transmembrane transport

[Term]
id: GO:0034635
name: glutathione transport
namespace: biological_process
def: "The directed movement of glutathione, the tripeptide glutamylcysteinylglycine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
is_a: GO:0015711 ! organic anion transport
is_a: GO:0042939 ! tripeptide transport
is_a: GO:0072337 ! modified amino acid transport
is_a: GO:0072348 ! sulfur compound transport

[Term]
id: GO:0034636
name: strand invasion involved in gene conversion at mating-type locus
namespace: biological_process
def: "The process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA at the mating-type locus. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules. This process occurs as part of gene conversion at the mating-type locus." [GOC:mah]
is_a: GO:0022414 ! reproductive process
is_a: GO:0042148 ! strand invasion
intersection_of: GO:0042148 ! strand invasion
intersection_of: part_of GO:0007534 ! gene conversion at mating-type locus
relationship: part_of GO:0007534 ! gene conversion at mating-type locus

[Term]
id: GO:0034637
name: cellular carbohydrate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, carried out by individual cells." [GOC:mah]
is_a: GO:0016051 ! carbohydrate biosynthetic process
is_a: GO:0044249 ! cellular biosynthetic process
is_a: GO:0044262 ! cellular carbohydrate metabolic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0034638
name: phosphatidylcholine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:jp]
subset: gosubset_prok
synonym: "phosphatidylcholine breakdown" EXACT []
synonym: "phosphatidylcholine catabolism" EXACT []
synonym: "phosphatidylcholine degradation" EXACT []
is_a: GO:0046164 ! alcohol catabolic process
is_a: GO:0046470 ! phosphatidylcholine metabolic process
is_a: GO:0046475 ! glycerophospholipid catabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process

[Term]
id: GO:0034639
name: L-amino acid efflux transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of an L-amino acid from the inside of the cell to the outside of the cell across a membrane." [GOC:mah]
synonym: "L-amino acid efflux permease activity" EXACT []
synonym: "L-amino acid export transporter activity" EXACT []
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity
is_a: GO:0015562 ! efflux transmembrane transporter activity

[Term]
id: GO:0034640
name: establishment of mitochondrion localization by microtubule attachment
namespace: biological_process
def: "The directed movement of a mitochondrion by attachment to a microtubule, followed by elongation of the microtubule by tubulin polymerization." [GOC:mah, PMID:12972644]
synonym: "establishment of mitochondrion localisation by microtubule attachment" EXACT [GOC:mah]
synonym: "mitochondrial localization by microtubule attachment" EXACT []
synonym: "mitochondrial migration by microtubule attachment" EXACT []
synonym: "mitochondrion migration by microtubule attachment" EXACT []
is_a: GO:0034643 ! establishment of mitochondrion localization, microtubule-mediated

[Term]
id: GO:0034641
name: cellular nitrogen compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells." [GOC:mah]
subset: goslim_chembl
subset: goslim_generic
subset: gosubset_prok
synonym: "cellular nitrogen compound metabolism" EXACT []
xref: Reactome:REACT_102000 "Metabolism of amino acids and derivatives, Mycobacterium tuberculosis"
xref: Reactome:REACT_103710 "Metabolism of amino acids and derivatives, Escherichia coli"
xref: Reactome:REACT_107293 "Metabolism of amino acids and derivatives, Arabidopsis thaliana"
xref: Reactome:REACT_108179 "Metabolism of amino acids and derivatives, Xenopus tropicalis"
xref: Reactome:REACT_109042 "Metabolism of amino acids and derivatives, Sus scrofa"
xref: Reactome:REACT_13 "Metabolism of amino acids and derivatives, Homo sapiens"
xref: Reactome:REACT_28699 "Metabolism of amino acids and derivatives, Saccharomyces cerevisiae"
xref: Reactome:REACT_29108 "Metabolism of amino acids and derivatives, Caenorhabditis elegans"
xref: Reactome:REACT_32429 "Metabolism of amino acids and derivatives, Rattus norvegicus"
xref: Reactome:REACT_33347 "Metabolism of amino acids and derivatives, Mus musculus"
xref: Reactome:REACT_34326 "Metabolism of amino acids and derivatives, Staphylococcus aureus N315"
xref: Reactome:REACT_55564 "Metabolism of amino acids and derivatives, Gallus gallus"
xref: Reactome:REACT_77741 "Metabolism of amino acids and derivatives, Taeniopygia guttata"
xref: Reactome:REACT_82379 "Metabolism of amino acids and derivatives, Bos taurus"
xref: Reactome:REACT_86268 "Metabolism of amino acids and derivatives, Drosophila melanogaster"
xref: Reactome:REACT_90299 "Metabolism of amino acids and derivatives, Oryza sativa"
xref: Reactome:REACT_91959 "Metabolism of amino acids and derivatives, Plasmodium falciparum"
xref: Reactome:REACT_93580 "Metabolism of amino acids and derivatives, Danio rerio"
xref: Reactome:REACT_95666 "Metabolism of amino acids and derivatives, Canis familiaris"
xref: Reactome:REACT_98086 "Metabolism of amino acids and derivatives, Dictyostelium discoideum"
xref: Reactome:REACT_99241 "Metabolism of amino acids and derivatives, Schizosaccharomyces pombe"
is_a: GO:0006807 ! nitrogen compound metabolic process
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0034642
name: mitochondrion migration along actin filament
namespace: biological_process
def: "The directed movement of a mitochondrion along a microfilament, mediated by motor proteins." [GOC:mah, PMID:15979253, PMID:16306220]
synonym: "mitochondrial migration along actin filament" EXACT [GOC:dph, GOC:tb]
synonym: "mitochondrial migration along microfilament" EXACT []
synonym: "mitochondrial migration, actin-mediated" EXACT []
synonym: "mitochondrion migration along microfilament" EXACT []
synonym: "mitochondrion transport along actin filament" EXACT []
is_a: GO:0030048 ! actin filament-based movement
is_a: GO:0051654 ! establishment of mitochondrion localization
is_a: GO:0099515 ! actin filament-based transport
is_a: GO:1902580 ! single-organism cellular localization

[Term]
id: GO:0034643
name: establishment of mitochondrion localization, microtubule-mediated
namespace: biological_process
def: "The directed movement of the mitochondrion to a specific location, by a process involving microtubules." [GOC:mah, PMID:12972644, PMID:15979253, PMID:16306220]
synonym: "establishment of mitochondrion localisation, microtubule-mediated" EXACT [GOC:mah]
synonym: "microtubule-mediated mitochondrion localization" EXACT []
synonym: "mitochondrial localization, microtubule-mediated" EXACT []
is_a: GO:0007017 ! microtubule-based process
is_a: GO:0051654 ! establishment of mitochondrion localization
is_a: GO:1902580 ! single-organism cellular localization

[Term]
id: GO:0034644
name: cellular response to UV
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:mah]
subset: gosubset_prok
synonym: "cellular response to ultraviolet light stimulus" EXACT []
synonym: "cellular response to ultraviolet radiation stimulus" EXACT []
synonym: "cellular response to UV light stimulus" EXACT []
synonym: "cellular response to UV radiation stimulus" EXACT []
is_a: GO:0009411 ! response to UV
is_a: GO:0071482 ! cellular response to light stimulus

[Term]
id: GO:0034645
name: cellular macromolecule biosynthetic process
namespace: biological_process
alt_id: GO:0034961
def: "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells." [CHEBI:33694, GOC:mah]
synonym: "cellular biopolymer biosynthetic process" EXACT [GOC:mtg_chebi_dec09]
synonym: "cellular macromolecule anabolism" EXACT [GOC:mah]
synonym: "cellular macromolecule biosynthesis" EXACT [GOC:mah]
synonym: "cellular macromolecule formation" EXACT [GOC:mah]
synonym: "cellular macromolecule synthesis" EXACT [GOC:mah]
is_a: GO:0009059 ! macromolecule biosynthetic process
is_a: GO:0044249 ! cellular biosynthetic process
is_a: GO:0044260 ! cellular macromolecule metabolic process

[Term]
id: GO:0034646
name: organelle-enclosing lipid monolayer
namespace: cellular_component
def: "A lipid monolayer that surrounds and encloses an organelle." [GOC:mah]
is_a: GO:0044446 ! intracellular organelle part

[Term]
id: GO:0034647
name: histone demethylase activity (H3-trimethyl-K4 specific)
namespace: molecular_function
def: "Catalysis of the removal of a methyl group from trimethylated lysine at position 4 of the histone H3 protein." [GOC:mah, PMID:17550896]
synonym: "histone demethylase activity (H3-K4-me3 specific)" EXACT []
is_a: GO:0032453 ! histone demethylase activity (H3-K4 specific)
relationship: part_of GO:0034721 ! histone H3-K4 demethylation, trimethyl-H3-K4-specific

[Term]
id: GO:0034648
name: histone demethylase activity (H3-dimethyl-K4 specific)
namespace: molecular_function
def: "Catalysis of the removal of a methyl group from dimethylated lysine at position 4 of the histone H3 protein." [GOC:mah, PMID:17550896]
synonym: "histone demethylase activity (H3-K4-me2 specific)" EXACT []
is_a: GO:0032453 ! histone demethylase activity (H3-K4 specific)

[Term]
id: GO:0034649
name: histone demethylase activity (H3-monomethyl-K4 specific)
namespace: molecular_function
def: "Catalysis of the reaction: histone H3 N6-methyl-L-lysine (position 4) + O2 + FAD + H2O = histone H3 L-lysine (position 4) + H2O2 + formaldehyde + FADH2. This reaction is the removal of a methyl group from monomethylated lysine at position 4 of the histone H3 protein." [GOC:mah, PMID:16223729]
synonym: "histone demethylase activity (H3-K4-me1 specific)" EXACT []
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
is_a: GO:0032453 ! histone demethylase activity (H3-K4 specific)

[Term]
id: GO:0034650
name: cortisol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cortisol, the steroid hormone 11-beta-17,21-trihydroxypregn-4-ene-3,20-dione. Cortisol is synthesized from cholesterol in the adrenal gland and controls carbohydrate, fat and protein metabolism and has anti-inflammatory properties." [CHEBI:17650, GOC:BHF, GOC:mah, GOC:rl]
synonym: "cortisol metabolism" EXACT []
is_a: GO:0006066 ! alcohol metabolic process
is_a: GO:0008211 ! glucocorticoid metabolic process
is_a: GO:0042180 ! cellular ketone metabolic process

[Term]
id: GO:0034651
name: cortisol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cortisol, the steroid hormone 11-beta-17,21-trihydroxypregn-4-ene-3,20-dione. Cortisol is synthesized from cholesterol in the adrenal gland and controls carbohydrate, fat and protein metabolism and has anti-inflammatory properties." [CHEBI:17650, GOC:BHF, GOC:mah, GOC:rl]
synonym: "cortisol anabolism" NARROW []
synonym: "cortisol biosynthesis" EXACT []
synonym: "cortisol formation" EXACT []
synonym: "cortisol synthesis" EXACT []
is_a: GO:0006704 ! glucocorticoid biosynthetic process
is_a: GO:0034650 ! cortisol metabolic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0046165 ! alcohol biosynthetic process

[Term]
id: GO:0034652
name: extrachromosomal circular DNA localization involved in cell aging
namespace: biological_process
def: "A process in which extrachromosomal circular DNA molecules are transported to, or maintained in, a specific location in cells contributing to their aging." [GOC:dph, GOC:jp, GOC:tb, PMID:18660802]
comment: Note that the term string was changed to be consistent with placement of this term in cell aging hierarchy.
synonym: "extrachromosomal circular DNA localisation involved in cell aging" EXACT [GOC:mah]
synonym: "extrachromosomal circular DNA localization during cell ageing" EXACT []
synonym: "extrachromosomal circular DNA localization during cell aging" RELATED [GOC:dph, GOC:tb]
is_a: GO:0001301 ! progressive alteration of chromatin involved in cell aging

[Term]
id: GO:0034653
name: retinoic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of retinoic acid, one of the three components that makes up vitamin A." [GOC:BHF, GOC:mah]
synonym: "retinoic acid breakdown" EXACT []
synonym: "retinoic acid catabolism" EXACT []
synonym: "retinoic acid degradation" EXACT []
synonym: "vitamin A1 acid catabolic process" EXACT []
is_a: GO:0016103 ! diterpenoid catabolic process
is_a: GO:0042363 ! fat-soluble vitamin catabolic process
is_a: GO:0042573 ! retinoic acid metabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0034654
name: nucleobase-containing compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah]
subset: gosubset_prok
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid anabolism" EXACT []
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid biosynthesis" EXACT []
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid formation" EXACT []
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid synthesis" NARROW []
is_a: GO:0006139 ! nucleobase-containing compound metabolic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process

[Term]
id: GO:0034655
name: nucleobase-containing compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah]
subset: goslim_chembl
subset: goslim_generic
subset: gosubset_prok
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid breakdown" EXACT []
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid catabolic process" RELATED [GOC:dph, GOC:tb]
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid catabolism" EXACT []
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid degradation" EXACT []
is_a: GO:0006139 ! nucleobase-containing compound metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0044270 ! cellular nitrogen compound catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process

[Term]
id: GO:0034656
name: nucleobase-containing small molecule catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide." [GOC:mah]
synonym: "nucleobase, nucleoside and nucleotide breakdown" EXACT []
synonym: "nucleobase, nucleoside and nucleotide catabolism" EXACT []
synonym: "nucleobase, nucleoside and nucleotide degradation" EXACT []
is_a: GO:0034655 ! nucleobase-containing compound catabolic process
is_a: GO:0044282 ! small molecule catabolic process
is_a: GO:0055086 ! nucleobase-containing small molecule metabolic process

[Term]
id: GO:0034657
name: GID complex
namespace: cellular_component
def: "A protein complex with ubiquitin ligase activity that is involved in proteasomal degradation of fructose-1,6-bisphosphatase (FBPase) and phosphoenolpyruvate carboxykinase during the transition from gluconeogenic to glycolytic growth conditions. In S. cerevisiae, the GID (Glucose Induced degradation Deficient) complex consists of Vid30p, Rmd5p, Vid24p, Vid28p, Gid7p, Gid8p, and Fyv10p." [PMID:12686616, PMID:18508925]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0034658
name: isopropylmalate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of isopropylmalate from one side of the membrane to the other." [GOC:mah]
is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity
relationship: part_of GO:0034659 ! isopropylmalate transport

[Term]
id: GO:0034659
name: isopropylmalate transport
namespace: biological_process
def: "The directed movement of isopropylmalate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
is_a: GO:0006835 ! dicarboxylic acid transport
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0015850 ! organic hydroxy compound transport

[Term]
id: GO:0034660
name: ncRNA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving non-coding RNA transcripts (ncRNAs)." [GOC:mah]
subset: gosubset_prok
synonym: "ncRNA metabolism" EXACT []
xref: Reactome:REACT_104424 "Metabolism of non-coding RNA, Sus scrofa"
xref: Reactome:REACT_107260 "Metabolism of non-coding RNA, Canis familiaris"
xref: Reactome:REACT_11052 "Metabolism of non-coding RNA, Homo sapiens"
xref: Reactome:REACT_31743 "Metabolism of non-coding RNA, Rattus norvegicus"
xref: Reactome:REACT_34395 "Metabolism of non-coding RNA, Taeniopygia guttata"
xref: Reactome:REACT_77416 "Metabolism of non-coding RNA, Gallus gallus"
xref: Reactome:REACT_82057 "Metabolism of non-coding RNA, Drosophila melanogaster"
xref: Reactome:REACT_87487 "Metabolism of non-coding RNA, Danio rerio"
xref: Reactome:REACT_91823 "Metabolism of non-coding RNA, Xenopus tropicalis"
xref: Reactome:REACT_92649 "Metabolism of non-coding RNA, Bos taurus"
xref: Reactome:REACT_94145 "Metabolism of non-coding RNA, Mus musculus"
is_a: GO:0016070 ! RNA metabolic process

[Term]
id: GO:0034661
name: ncRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of non-coding RNA transcripts (ncRNAs). Includes the breakdown of cryptic unstable transcripts (CUTs)." [GOC:rb, PMID:18591258]
synonym: "ncRNA breakdown" EXACT []
synonym: "ncRNA catabolism" EXACT []
synonym: "ncRNA degradation" EXACT []
is_a: GO:0006401 ! RNA catabolic process
is_a: GO:0034660 ! ncRNA metabolic process

[Term]
id: GO:0034662
name: CFTR-NHERF-ezrin complex
namespace: cellular_component
def: "A protein complex that contains ezrin, Na+/H+ exchanger regulatory factor (NHERF, also called EBP50), and two copies of the cystic fibrosis transmembrane conductance regulator (CFTR). The CFTR molecules interact with NHERF via their cytoplasmic tail domains; the complex is thought to link the CFTR channel to the actin cytoskeleton and contribute to the regulation of channel activity." [PMID:16129695, PMID:16798722, PMID:16926444]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0034663
name: endoplasmic reticulum chaperone complex
namespace: cellular_component
def: "A protein complex that is located in the endoplasmic reticulum and is composed of chaperone proteins, including BiP, GRP94; CaBP1, protein disulfide isomerase (PDI), ERdj3, cyclophilin B, ERp72, GRP170, UDP-glucosyltransferase, and SDF2-L1." [PMID:12475965]
synonym: "endoplasmic reticulum network complex" RELATED []
synonym: "ER chaperone complex" EXACT []
synonym: "ER network complex" RELATED []
is_a: GO:0043234 ! protein complex
is_a: GO:0044432 ! endoplasmic reticulum part

[Term]
id: GO:0034664
name: Ig heavy chain-bound endoplasmic reticulum chaperone complex
namespace: cellular_component
def: "A protein complex that is located in the endoplasmic reticulum (ER) and is formed by the association of an immunoglobulin heavy chain with the proteins of the ER chaperone complex; the latter include BiP, GRP94; CaBP1, protein disulfide isomerase (PDI), ERdj3, cyclophilin B, ERp72, GRP170, UDP-glucosyltransferase, and SDF2-L1." [PMID:12475965]
synonym: "Ig heavy chain-bound ER chaperone complex" EXACT []
synonym: "immunoglobulin heavy chain-bound endoplasmic reticulum chaperone complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044432 ! endoplasmic reticulum part

[Term]
id: GO:0034665
name: integrin alpha1-beta1 complex
namespace: cellular_component
def: "An integrin complex that comprises one alpha1 subunit and one beta1 subunit." [PMID:12297042]
synonym: "alpha1-beta1 integrin complex" EXACT []
synonym: "ITGA1-ITGB1 complex" NARROW []
synonym: "VLA-1 complex" EXACT []
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034666
name: integrin alpha2-beta1 complex
namespace: cellular_component
def: "An integrin complex that comprises one alpha2 subunit and one beta1 subunit." [PMID:12297042]
synonym: "ITGA2-ITGB1 complex" NARROW [CORUM:2432]
synonym: "VLA-2 complex" EXACT [PMID:3546305]
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034667
name: integrin alpha3-beta1 complex
namespace: cellular_component
def: "An integrin complex that comprises one alpha3 subunit and one beta1 subunit." [PMID:12297042]
synonym: "alpha3-beta1 integrin complex" EXACT []
synonym: "ITGA3-ITGB1 complex" NARROW [CORUM:2406]
synonym: "VLA-3 complex" EXACT [PMID:3546305]
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034668
name: integrin alpha4-beta1 complex
namespace: cellular_component
def: "An integrin complex that comprises one alpha4 subunit and one beta1 subunit." [PMID:12297042]
synonym: "alpha4-beta1 integrin complex" EXACT []
synonym: "ITGA4-ITGB1 complex" NARROW []
synonym: "VLA-4 complex" EXACT []
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034669
name: integrin alpha4-beta7 complex
namespace: cellular_component
def: "An integrin complex that comprises one alpha4 subunit and one beta7 subunit." [PMID:12297042]
synonym: "alpha4-beta7 integrin complex" EXACT []
synonym: "ITGA4-ITGB7 complex" NARROW []
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034670
name: chemotaxis to arachidonic acid
namespace: biological_process
def: "The directed movement of a motile cell or organism in response to the presence of arachidonic acid." [GOC:go_curators, PMID:18202452]
is_a: GO:0006935 ! chemotaxis
is_a: GO:1904550 ! response to arachidonic acid

[Term]
id: GO:0034671
name: retinoic acid receptor signaling pathway involved in pronephros anterior/posterior pattern specification
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that results in the spatial identity of regions along the anterior-posterior axis of the pronephros." [GOC:mh]
synonym: "retinoic acid receptor signaling pathway involved in pronephric kidney anterior/posterior pattern specification" EXACT [GOC:mtg_kidney_jan10]
synonym: "retinoic acid receptor signalling pathway involved in pronephros anterior-posterior patterning" EXACT [GOC:mah]
is_a: GO:0048384 ! retinoic acid receptor signaling pathway
intersection_of: GO:0048384 ! retinoic acid receptor signaling pathway
intersection_of: part_of GO:0034672 ! anterior/posterior pattern specification involved in pronephros development
relationship: part_of GO:0034672 ! anterior/posterior pattern specification involved in pronephros development

[Term]
id: GO:0034672
name: anterior/posterior pattern specification involved in pronephros development
namespace: biological_process
def: "The developmental process that results in the creation of defined areas or spaces within the pronephros along the anterior/posterior axis to which cells respond and eventually are instructed to differentiate." [GOC:mah]
synonym: "anterior/posterior pattern specification involved in pronephric kidney development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0039017 ! pattern specification involved in pronephros development
is_a: GO:0072098 ! anterior/posterior pattern specification involved in kidney development
intersection_of: GO:0009952 ! anterior/posterior pattern specification
intersection_of: part_of GO:0048793 ! pronephros development
relationship: part_of GO:0048793 ! pronephros development

[Term]
id: GO:0034673
name: inhibin-betaglycan-ActRII complex
namespace: cellular_component
def: "A protein complex that consists of inhibin, type III transforming growth factor beta receptor (also known as betaglycan), and the type II activin receptor ActRII. The complex is thought to negatively regulate the activity of activin B." [GOC:BHF, PMID:10746731]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0034674
name: integrin alpha5-beta1 complex
namespace: cellular_component
def: "An integrin complex that comprises one alpha5 subunit and one beta1 subunit." [PMID:12297042]
synonym: "alpha5-beta1 integrin complex" EXACT []
synonym: "ITGA5-ITGB1 complex" NARROW []
synonym: "VLA-5 complex" EXACT []
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034675
name: integrin alpha6-beta1 complex
namespace: cellular_component
def: "An integrin complex that comprises one alpha6 subunit and one beta1 subunit." [PMID:12297042]
synonym: "alpha6-beta1 integrin complex" EXACT []
synonym: "ITGA6-ITGB1 complex" NARROW [CORUM:2413]
synonym: "VLA-6 complex" EXACT [PMID:2649503]
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034676
name: integrin alpha6-beta4 complex
namespace: cellular_component
def: "An integrin complex that comprises one alpha6 subunit and one beta1 subunit." [PMID:12297042]
synonym: "alpha6-beta4 integrin complex" EXACT []
synonym: "ITGA6-ITGB4 complex" NARROW [CORUM:2323]
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034677
name: integrin alpha7-beta1 complex
namespace: cellular_component
def: "An integrin complex that comprises one alpha7 subunit and one beta1 subunit." [PMID:12297042]
synonym: "alpha7-beta1 integrin complex" EXACT []
synonym: "ITGA7-ITGB1 complex" NARROW []
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034678
name: integrin alpha8-beta1 complex
namespace: cellular_component
def: "An integrin complex that comprises one alpha8 subunit and one beta1 subunit." [PMID:12297042]
synonym: "alpha8-beta1 integrin complex" EXACT []
synonym: "ITGA8-ITGB1 complex" NARROW [CORUM:2439]
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034679
name: integrin alpha9-beta1 complex
namespace: cellular_component
def: "An integrin complex that comprises one alpha9 subunit and one beta1 subunit." [PMID:12297042]
synonym: "alpha9-beta1 integrin complex" EXACT []
synonym: "ITGA9-ITGB1 complex" NARROW []
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034680
name: integrin alpha10-beta1 complex
namespace: cellular_component
def: "An integrin complex that comprises one alpha10 subunit and one beta1 subunit." [PMID:12297042]
synonym: "alpha10-beta1 integrin complex" EXACT []
synonym: "ITGA10-ITGB1 complex" NARROW [CORUM:3057]
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034681
name: integrin alpha11-beta1 complex
namespace: cellular_component
def: "An integrin complex that comprises one alpha11 subunit and one beta1 subunit." [PMID:12297042]
synonym: "alpha11-beta1 integrin complex" EXACT []
synonym: "ITGA11-ITGB1 complex" NARROW [CORUM:3058]
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034682
name: integrin alphav-beta1 complex
namespace: cellular_component
def: "An integrin complex that comprises one alphav subunit and one beta1 subunit." [PMID:12297042]
synonym: "alphav-beta1 integrin complex" EXACT []
synonym: "ITGAV-ITGB1 complex" NARROW [CORUM:2436]
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034683
name: integrin alphav-beta3 complex
namespace: cellular_component
def: "An integrin complex that comprises one alphav subunit and one beta3 subunit." [PMID:12297042]
synonym: "alphav-beta3 integrin complex" EXACT []
synonym: "ITGAV-ITGB3 complex" NARROW [CORUM:2816]
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034684
name: integrin alphav-beta5 complex
namespace: cellular_component
def: "An integrin complex that comprises one alphav subunit and one beta5 subunit." [PMID:12297042]
synonym: "alphav-beta5 integrin complex" EXACT []
synonym: "ITGAV-ITGB5 complex" NARROW [CORUM:2350]
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034685
name: integrin alphav-beta6 complex
namespace: cellular_component
def: "An integrin complex that comprises one alphav subunit and one beta6 subunit." [PMID:12297042]
synonym: "alphav-beta6 integrin complex" EXACT []
synonym: "ITGAV-ITGB6 complex" NARROW [CORUM:2354]
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034686
name: integrin alphav-beta8 complex
namespace: cellular_component
def: "An integrin complex that comprises one alphav subunit and one beta8 subunit." [PMID:12297042]
synonym: "alphav-beta8 integrin complex" EXACT []
synonym: "ITGAV-ITGB8 complex" NARROW []
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034687
name: integrin alphaL-beta2 complex
namespace: cellular_component
def: "An integrin complex that comprises one alphaL subunit and one beta2 subunit." [PMID:12297042]
synonym: "alphaL-beta2 integrin complex" EXACT []
synonym: "Itgal-Itgb2 complex" NARROW []
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034688
name: integrin alphaM-beta2 complex
namespace: cellular_component
def: "An integrin complex that comprises one alphaM subunit and one beta2 subunit." [PMID:12297042]
synonym: "alphaM-beta2 integrin complex" EXACT []
synonym: "Itgam-Itgb2 complex" NARROW []
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034689
name: integrin alphaX-beta2 complex
namespace: cellular_component
def: "An integrin complex that comprises one alphaX subunit and one beta2 subunit." [PMID:12297042]
synonym: "alphaX-beta2 integrin complex" EXACT []
synonym: "Itgax-Itgb2 complex" NARROW []
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034690
name: integrin alphaD-beta2 complex
namespace: cellular_component
def: "An integrin complex that comprises one alphaD subunit and one beta2 subunit." [PMID:12297042]
synonym: "alphaD-beta2 integrin complex" EXACT []
synonym: "Itgad-Itgb2 complex" NARROW []
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034691
name: integrin alphaE-beta7 complex
namespace: cellular_component
def: "An integrin complex that comprises one alphaE subunit and one beta7 subunit." [PMID:12297042]
synonym: "Itgae-Itgb7 complex" NARROW []
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034692
name: E.F.G complex
namespace: cellular_component
def: "A protein complex that comprises three core spliceosomal proteins, designated E, F, and G. Formation of the E.F.G complex is essential but not sufficient for the formation of a stable U1 snRNP complex." [PMID:8641291]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0034693
name: U11/U12 snRNP
namespace: cellular_component
def: "A ribonucleoprotein complex formed by the association of the U11 and U12 small nuclear ribonucleoproteins." [GOC:mah, PMID:15146077]
synonym: "18S U11/U12 snRNP" NARROW []
synonym: "snRNP U11/U12" EXACT [GOC:mah]
is_a: GO:0097525 ! spliceosomal snRNP complex

[Term]
id: GO:0034694
name: response to prostaglandin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin stimulus." [GOC:BHF, GOC:vk]
synonym: "response to prostaglandin stimulus" EXACT [GOC:dos]
is_a: GO:0009725 ! response to hormone
is_a: GO:0070542 ! response to fatty acid

[Term]
id: GO:0034695
name: response to prostaglandin E
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus." [GOC:BHF, GOC:vk]
synonym: "response to prostaglandin E stimulus" EXACT [GOC:dos]
is_a: GO:0034694 ! response to prostaglandin
is_a: GO:1901654 ! response to ketone

[Term]
id: GO:0034696
name: response to prostaglandin F
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin F stimulus." [GOC:BHF, GOC:vk]
synonym: "response to prostaglandin F stimulus" EXACT [GOC:dos]
is_a: GO:0034694 ! response to prostaglandin

[Term]
id: GO:0034697
name: response to prostaglandin I
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin I stimulus." [GOC:BHF, GOC:vk]
synonym: "response to prostaglandin I stimulus" EXACT [GOC:dos]
is_a: GO:0034694 ! response to prostaglandin

[Term]
id: GO:0034698
name: response to gonadotropin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin stimulus." [GOC:BHF, GOC:vk]
synonym: "response to gonadotropin stimulus" EXACT [GOC:dos]
is_a: GO:0009725 ! response to hormone

[Term]
id: GO:0034699
name: response to luteinizing hormone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a luteinizing hormone stimulus." [GOC:BHF, GOC:vk]
synonym: "response to luteinizing hormone stimulus" EXACT [GOC:dos]
is_a: GO:0034698 ! response to gonadotropin

[Term]
id: GO:0034700
name: allulose 6-phosphate 3-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-allulose 6-phosphate = D-fructose 6-phosphate." [GOC:imk]
xref: MetaCyc:RXN0-304
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0034701
name: tripeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a tripeptide." [GOC:mah]
xref: EC:3.4.13
xref: MetaCyc:3.4.11.4-RXN
is_a: GO:0008238 ! exopeptidase activity

[Term]
id: GO:0034702
name: ion channel complex
namespace: cellular_component
def: "A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient." [GOC:mah, ISBN:071673706X]
is_a: GO:1902495 ! transmembrane transporter complex
relationship: part_of GO:0016021 ! integral component of membrane

[Term]
id: GO:0034703
name: cation channel complex
namespace: cellular_component
def: "An ion channel complex through which cations pass." [GOC:mah]
is_a: GO:0034702 ! ion channel complex

[Term]
id: GO:0034704
name: calcium channel complex
namespace: cellular_component
def: "An ion channel complex through which calcium ions pass." [GOC:mah]
is_a: GO:0034703 ! cation channel complex

[Term]
id: GO:0034705
name: potassium channel complex
namespace: cellular_component
def: "An ion channel complex through which potassium ions pass." [GOC:mah]
is_a: GO:0034703 ! cation channel complex

[Term]
id: GO:0034706
name: sodium channel complex
namespace: cellular_component
def: "An ion channel complex through which sodium ions pass." [GOC:mah]
is_a: GO:0034703 ! cation channel complex

[Term]
id: GO:0034707
name: chloride channel complex
namespace: cellular_component
def: "An ion channel complex through which chloride ions pass." [GOC:mah]
is_a: GO:0034702 ! ion channel complex

[Term]
id: GO:0034708
name: methyltransferase complex
namespace: cellular_component
def: "A protein complex that possesses methyltransferase activity." [GOC:mah]
subset: gosubset_prok
is_a: GO:0044424 ! intracellular part
is_a: GO:1990234 ! transferase complex

[Term]
id: GO:0034709
name: methylosome
namespace: cellular_component
def: "A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifies specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins, thereby targeting these proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles. Proteins found in the methylosome include the methyltransferase JBP1 (PRMT5), pICln (CLNS1A), MEP50 (WDR77), and unmethylated forms of SM proteins that have RG domains." [PMID:11713266, PMID:11756452]
synonym: "20S methylosome" EXACT []
synonym: "20S methyltransferase complex" EXACT []
is_a: GO:0034708 ! methyltransferase complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0034710
name: inhibin complex binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an inhibin complex, a dimer of one inhibin-alpha subunit and one inhibin-beta subunit." [GOC:BHF, GOC:mah]
is_a: GO:0032403 ! protein complex binding

[Term]
id: GO:0034711
name: inhibin binding
namespace: molecular_function
alt_id: GO:0034712
alt_id: GO:0048186
alt_id: GO:0048187
def: "Interacting selectively and non-covalently with an inhibin monomer, any of the polypeptides that combine to form activin and inhibin dimers." [GOC:BHF, GOC:mah]
synonym: "inhibin alpha binding" NARROW []
synonym: "inhibin beta-A binding" NARROW []
synonym: "inhibin beta-B binding" NARROW []
synonym: "inhibin monomer binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0034713
name: type I transforming growth factor beta receptor binding
namespace: molecular_function
alt_id: GO:0005103
alt_id: GO:0005116
alt_id: GO:0005120
def: "Interacting selectively and non-covalently with a type I transforming growth factor beta receptor." [GOC:BHF, GOC:mah]
synonym: "babo binding" NARROW []
synonym: "babo ligand" NARROW []
synonym: "baboon binding" NARROW []
synonym: "baboon ligand" NARROW []
synonym: "baboon receptor ligand" NARROW []
synonym: "sax binding" NARROW []
synonym: "sax ligand" NARROW []
synonym: "saxophone binding" NARROW []
synonym: "saxophone ligand" NARROW []
synonym: "TGF-beta type I binding" EXACT []
synonym: "thickveins binding" NARROW []
synonym: "thickveins ligand" NARROW []
synonym: "tkv binding" NARROW []
synonym: "tkv ligand" NARROW []
synonym: "transforming growth factor beta ligand binding to type I receptor" RELATED []
synonym: "transforming growth factor beta receptor type I binding" EXACT []
synonym: "type I TGF-beta binding" EXACT []
is_a: GO:0005160 ! transforming growth factor beta receptor binding

[Term]
id: GO:0034714
name: type III transforming growth factor beta receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type III transforming growth factor beta receptor." [GOC:BHF, GOC:mah]
synonym: "betaglycan binding" RELATED []
synonym: "TGF-beta type III binding" EXACT []
synonym: "transforming growth factor beta ligand binding to type III receptor" RELATED []
synonym: "transforming growth factor beta receptor type III binding" EXACT []
synonym: "type IIII TGF-beta binding" EXACT []
is_a: GO:0005160 ! transforming growth factor beta receptor binding

[Term]
id: GO:0034715
name: pICln-Sm protein complex
namespace: cellular_component
def: "A protein complex that contains pICln (CLNS1A) and several Sm proteins, including SmD1, SmD2, SmE, SmF, and SmG." [GOC:mah, PMID:11713266]
synonym: "6S pICln complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0034716
name: Gemin3-Gemin4-Gemin5 complex
namespace: cellular_component
def: "A protein complex that contains Gemin3 (DDX20), Gemin4, and Gemin5, and can bind to snRNAs; may be an intermediate in SMN complex assembly." [GOC:mah, PMID:17640873]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0034717
name: Gemin6-Gemin7-unrip complex
namespace: cellular_component
def: "A protein complex that contains Gemin6, Gemin7, and unrip (STRAP), and can bind to snRNAs; may play a role in snRNP assembly." [GOC:mah, PMID:17640873]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0034718
name: SMN-Gemin2 complex
namespace: cellular_component
def: "A protein complex that contains the survival motor neuron (SMN) protein and Gemin2; may form the stable core of the larger SMN complex." [GOC:mah, PMID:17640873]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0034719
name: SMN-Sm protein complex
namespace: cellular_component
def: "A protein complex formed by the association of several methylated Sm proteins with the SMN complex; the latter contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and unrip proteins; additional proteins, including galectin-1 and galectin-3, are also found in the SMN-SM complex. The SMN-Sm complex is involved in spliceosomal snRNP assembly in the cytoplasm." [PMID:11522829, PMID:17401408]
comment: Note that this complex is sometimes referred to as the 'SMN complex', but it should not be confused with GO:0032797.
synonym: "SMN-containing protein complex" BROAD []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0034720
name: histone H3-K4 demethylation
namespace: biological_process
def: "The modification of histone H3 by the removal of a methyl group from lysine at position 4 of the histone." [GOC:mah]
synonym: "H3K4 demethylation (me1 me2 and me3)" RELATED []
is_a: GO:0070076 ! histone lysine demethylation

[Term]
id: GO:0034721
name: histone H3-K4 demethylation, trimethyl-H3-K4-specific
namespace: biological_process
def: "The modification of histone H3 by the removal of a methyl group from a trimetylated lysine at position 4 of the histone." [GOC:mah]
synonym: "H3K4 demethylation (me3)" EXACT []
synonym: "histone H3-K4 tridemethylation" RELATED []
is_a: GO:0034720 ! histone H3-K4 demethylation

[Term]
id: GO:0034722
name: gamma-glutamyl-peptidase activity
namespace: molecular_function
def: "Catalysis of the cleavage of a gamma-linked glutamate bond." [EC:3.4.19.9, MEROPS_fam:C26]
subset: gosubset_prok
synonym: "gamma-glutamyl hydrolase activity" EXACT [EC:3.4.19.9]
xref: EC:3.4.19.9
xref: MetaCyc:3.4.19.9-RXN
is_a: GO:0008242 ! omega peptidase activity

[Term]
id: GO:0034723
name: DNA replication-dependent nucleosome organization
namespace: biological_process
def: "The formation or destruction of chromatin structures on newly replicated DNA, coupled to strand elongation." [GOC:mah, PMID:17510629]
synonym: "DNA replication-dependent nucleosome organisation" EXACT [GOC:curators]
is_a: GO:0006333 ! chromatin assembly or disassembly
is_a: GO:0034728 ! nucleosome organization

[Term]
id: GO:0034724
name: DNA replication-independent nucleosome organization
namespace: biological_process
def: "The formation or destruction of chromatin structures, occurring outside the context of DNA replication." [GOC:mah, PMID:17510629]
synonym: "DNA replication-independent nucleosome organisation" EXACT [GOC:curators]
is_a: GO:0006333 ! chromatin assembly or disassembly
is_a: GO:0034728 ! nucleosome organization

[Term]
id: GO:0034725
name: DNA replication-dependent nucleosome disassembly
namespace: biological_process
def: "The controlled breakdown of nucleosomes on newly replicated DNA, coupled to strand elongation." [GOC:mah, PMID:17510629]
is_a: GO:0006337 ! nucleosome disassembly
is_a: GO:0034723 ! DNA replication-dependent nucleosome organization

[Term]
id: GO:0034726
name: DNA replication-independent nucleosome disassembly
namespace: biological_process
def: "The controlled breakdown of nucleosomes outside the context of DNA replication." [GOC:mah, PMID:17510629]
is_a: GO:0006337 ! nucleosome disassembly
is_a: GO:0034724 ! DNA replication-independent nucleosome organization

[Term]
id: GO:0034727
name: piecemeal microautophagy of nucleus
namespace: biological_process
def: "Degradation of a cell nucleus by lysosomal microautophagy." [GOC:jp, PMID:18701704]
synonym: "PMN" EXACT []
is_a: GO:0016237 ! lysosomal microautophagy
is_a: GO:0044804 ! nucleophagy

[Term]
id: GO:0034728
name: nucleosome organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of one or more nucleosomes." [GOC:mah]
synonym: "nucleosome organisation" EXACT [GOC:curators]
is_a: GO:0006325 ! chromatin organization
is_a: GO:0071822 ! protein complex subunit organization
is_a: GO:0071824 ! protein-DNA complex subunit organization

[Term]
id: GO:0034729
name: histone H3-K79 methylation
namespace: biological_process
def: "The modification of histone H3 by addition of a methyl group to lysine at position 79 of the histone." [GOC:se]
synonym: "histone H3 K79 methylation" EXACT []
synonym: "histone H3K79me" EXACT []
synonym: "histone lysine H3 K79 methylation" EXACT []
is_a: GO:0034968 ! histone lysine methylation

[Term]
id: GO:0034730
name: SmD-containing SMN-Sm protein complex
namespace: cellular_component
def: "An SMN-Sm protein complex formed by the association of the methylated Sm proteins B/B', D1, D2, D3, E, F, and G with the SMN complex." [PMID:12975319, PMID:17401408]
synonym: "SMN-containing protein complex" BROAD []
is_a: GO:0034719 ! SMN-Sm protein complex

[Term]
id: GO:0034731
name: Lsm-containing SMN-Sm protein complex
namespace: cellular_component
def: "An SMN-Sm protein complex formed by the association of the methylated Sm proteins B/B', D3, E, F, and G, and Lsm10 and Lsm11, with the SMN complex. This complex forms Sm cores on U7 snRNA." [PMID:12975319, PMID:17401408]
synonym: "SMN-containing protein complex" BROAD []
is_a: GO:0034719 ! SMN-Sm protein complex

[Term]
id: GO:0034732
name: transcription factor TFIIIB-alpha complex
namespace: cellular_component
def: "A transcription factor TFIIIB-beta complex that contains the TATA-binding protein (TBP), B'' and a specialized homolog of the conserved subunit BRF referred to as BRFU or TFIIIB50, which found in human but not conserved in yeast; the complex is involved in the regulation of transcription from type 3 (upstream) RNA polymerase III promoters." [PMID:11433012]
is_a: GO:0000126 ! transcription factor TFIIIB complex

[Term]
id: GO:0034733
name: transcription factor TFIIIB-beta complex
namespace: cellular_component
def: "A transcription factor TFIIIB-beta complex that contains the TATA-binding protein (TBP), B'' and BRF, and is involved in the regulation of transcription from type 2 RNA polymerase III promoters." [PMID:11433012]
comment: Note that the subunits of TFIIIB-beta are conserved between human and yeast; however, in yeast a single TFIIIB complex regulates transcription of tRNA, 5S rRNA and U6 snRNA genes, whereas two different TBP-dependent TFIIIB activities exist in humans.
is_a: GO:0000126 ! transcription factor TFIIIB complex

[Term]
id: GO:0034734
name: transcription factor TFIIIC1 complex
namespace: cellular_component
def: "A transcription factor complex that forms part of the TFIIIC complex, observed in human. The complex is poorly characterized, but contains the 250-kDa form of HsBdp1, and is thought to include nuclear factor 1 (NF1). It stimulates binding by human TFIIIC2 and is required for transcription activity." [GOC:mah, PMID:11433012, PMID:15096501]
is_a: GO:0090576 ! RNA polymerase III transcription factor complex
relationship: part_of GO:0000127 ! transcription factor TFIIIC complex

[Term]
id: GO:0034735
name: transcription factor TFIIIC2 complex
namespace: cellular_component
def: "A transcription factor complex that forms part of the TFIIIC complex, observed in human; composed of five subunits (GTF3C1/hTFIIIC220/TFIIICalpha, GTF3C2/hTFIIIC110/TFIIICbeta, GTF3C3/hTFIIIC102/TFIIICgamma, GTF3C4/hTFIIIC90/TFIIICdelta and GTF3C5/hTFIIIC63/TFIIICepsilon in human) that together recognize the type 2 RNA polymerase III promoter." [GOC:mah, PMID:11433012]
is_a: GO:0090576 ! RNA polymerase III transcription factor complex
relationship: part_of GO:0000127 ! transcription factor TFIIIC complex

[Term]
id: GO:0034736
name: cholesterol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + cholesterol = a cholesterol ester + CoA." [EC:2.3.1.26, RHEA:17732]
synonym: "ACAT activity" BROAD [EC:2.3.1.26]
synonym: "acyl coenzyme A-cholesterol-O-acyltransferase activity" EXACT [EC:2.3.1.26]
synonym: "acyl-CoA:cholesterol acyltransferase activity" EXACT [EC:2.3.1.26]
synonym: "acyl-CoA:cholesterol O-acyltransferase activity" EXACT [EC:2.3.1.26]
synonym: "acylcoenzyme A:cholesterol O-acyltransferase activity" EXACT []
synonym: "cholesterol acyltransferase activity" BROAD [EC:2.3.1.26]
synonym: "cholesterol ester synthetase activity" EXACT [EC:2.3.1.26]
synonym: "cholesteryl ester synthetase activity" EXACT [EC:2.3.1.26]
xref: EC:2.3.1.26
xref: KEGG:R01461
xref: MetaCyc:STEROL-O-ACYLTRANSFERASE-RXN
xref: RHEA:17732
is_a: GO:0004772 ! sterol O-acyltransferase activity

[Term]
id: GO:0034737
name: ergosterol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + ergosterol = CoA + ergosterol ester." [GOC:mah]
xref: EC:2.3.1.-
is_a: GO:0004772 ! sterol O-acyltransferase activity

[Term]
id: GO:0034738
name: lanosterol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + lanosterol = CoA + lanosterol ester." [GOC:mah]
xref: EC:2.3.1.-
is_a: GO:0004772 ! sterol O-acyltransferase activity

[Term]
id: GO:0034739
name: histone deacetylase activity (H4-K16 specific)
namespace: molecular_function
def: "Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + H2O = histone H4 L-lysine (position 16) + acetate. This reaction represents the removal of an acetyl group from lysine at position 16 of the histone H4 protein." [EC:3.5.1.17, GOC:vw, RHEA:24551]
is_a: GO:0004407 ! histone deacetylase activity
relationship: part_of GO:0070933 ! histone H4 deacetylation

[Term]
id: GO:0034740
name: TFIIIC-TOP1-SUB1 complex
namespace: cellular_component
def: "A protein complex that contains TFIIIC, topoisomerase 1, and Sub1/PC4. Characterized in human, the complex is involved in regulating transcription from RNA polymerase III (Pol III) promoters. Topoisomerase 1 and Sub1 enhance the accuracy of transcription termination, and promote reinitiation by Pol III." [PMID:9660958]
synonym: "TFIIIC-Topoisomerase 1-PC4 complex" EXACT []
is_a: GO:0044451 ! nucleoplasm part
is_a: GO:0090576 ! RNA polymerase III transcription factor complex
relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme

[Term]
id: GO:0034741
name: APC-tubulin-IQGAP1 complex
namespace: cellular_component
def: "A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), alpha-tubulin, gamma-tubulin, and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization." [PMID:17126424]
comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
synonym: "60S APC complex" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0034743
name: APC-IQGAP complex
namespace: cellular_component
def: "A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC) and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization and cell migration." [PMID:15572129]
comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0031252 ! cell leading edge

[Term]
id: GO:0034744
name: APC-IQGAP1-Cdc42 complex
namespace: cellular_component
def: "A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), the small GTPase Cdc42, and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization and cell migration." [PMID:15572129]
comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0031252 ! cell leading edge

[Term]
id: GO:0034745
name: APC-IQGAP1-Rac1 complex
namespace: cellular_component
def: "A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), the small GTPase Rac1, and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization and cell migration." [PMID:15572129]
comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0031252 ! cell leading edge

[Term]
id: GO:0034746
name: APC-IQGAP1-CLIP-170 complex
namespace: cellular_component
def: "A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), the small GTPase Cdc42, and CLIP-170; may play a role in cytoskeleton organization and cell migration." [PMID:15572129]
comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0031252 ! cell leading edge

[Term]
id: GO:0034748
name: Par3-APC-KIF3A complex
namespace: cellular_component
def: "A protein complex that contains Par3, the tumor suppressor protein adenomatous polyposis coli (APC), and the kinesin-related protein KIF3A; involved in establishing neuronal cell polarity." [PMID:15556865]
comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0034749
name: Scrib-APC complex
namespace: cellular_component
def: "A protein complex that contains the Scribble protein (a cell polarity determinant) and the tumor suppressor protein adenomatous polyposis coli (APC); may be involved in the control of cell proliferation." [PMID:16611247]
comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
synonym: "hScrib-APC complex" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0034750
name: Scrib-APC-beta-catenin complex
namespace: cellular_component
def: "A protein complex that contains the Scribble protein (a cell polarity determinant), the tumor suppressor protein adenomatous polyposis coli (APC), and beta-catenin; may be involved in the control of cell proliferation." [PMID:16611247]
comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
synonym: "hScrib-APC-beta-catenin complex" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0034751
name: aryl hydrocarbon receptor complex
namespace: cellular_component
def: "A protein complex that acts as an aryl hydrocarbon (Ah) receptor. Cytosolic and nuclear Ah receptor complexes have different subunit composition, but both contain the ligand-binding subunit AhR." [GOC:mah, PMID:7598497]
synonym: "AhR complex" EXACT []
synonym: "AHRC" EXACT []
is_a: GO:0043235 ! receptor complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0034752
name: cytosolic aryl hydrocarbon receptor complex
namespace: cellular_component
def: "An aryl hydrocarbon receptor complex found in the cytosol, in which the ligand-binding subunit AhR is not bound to ligand; consists of AhR, two molecules of HSP90, the protein kinase c-Src, and the immunophilin XAP2/AIP." [PMID:7598497, PMID:8937476, PMID:9447995]
synonym: "9S-cytosolic aryl hydrocarbon (Ah) receptor non-ligand activated complex" RELATED []
synonym: "cytosolic AhR complex" EXACT []
synonym: "cytosolic AHRC" EXACT []
is_a: GO:0034751 ! aryl hydrocarbon receptor complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0034753
name: nuclear aryl hydrocarbon receptor complex
namespace: cellular_component
def: "An aryl hydrocarbon receptor (AhR) complex found in the nucleus; ; consists of ligand-bound AhR and the aryl hydrocarbon receptor nuclear translocator (ARNT)." [PMID:7598497]
synonym: "6S-nuclear aryl hydrocarbon (Ah) receptor ligand-activated complex" RELATED []
synonym: "nuclear AhR complex" EXACT []
synonym: "nuclear AHRC" EXACT []
is_a: GO:0034751 ! aryl hydrocarbon receptor complex
is_a: GO:0044428 ! nuclear part
intersection_of: GO:0034751 ! aryl hydrocarbon receptor complex
intersection_of: part_of GO:0005634 ! nucleus
relationship: part_of GO:0005634 ! nucleus

[Term]
id: GO:0034754
name: cellular hormone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone, as carried out by individual cells." [GOC:mah]
is_a: GO:0042445 ! hormone metabolic process
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0034755
name: iron ion transmembrane transport
namespace: biological_process
def: "A process in which an iron ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
subset: gosubset_prok
synonym: "iron ion membrane transport" EXACT []
synonym: "transmembrane iron transport" EXACT []
is_a: GO:0006826 ! iron ion transport
is_a: GO:0098662 ! inorganic cation transmembrane transport

[Term]
id: GO:0034756
name: regulation of iron ion transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of iron ions (Fe) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "regulation of Fe transport" EXACT []
synonym: "regulation of iron transport" EXACT []
is_a: GO:0010959 ! regulation of metal ion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006826 ! iron ion transport
relationship: regulates GO:0006826 ! iron ion transport

[Term]
id: GO:0034757
name: negative regulation of iron ion transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of iron ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "down regulation of iron ion transport" EXACT []
synonym: "down-regulation of iron ion transport" EXACT []
synonym: "downregulation of iron ion transport" EXACT []
synonym: "inhibition of iron ion transport" NARROW []
synonym: "negative regulation of iron transport" EXACT []
is_a: GO:0034756 ! regulation of iron ion transport
is_a: GO:0043271 ! negative regulation of ion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006826 ! iron ion transport
relationship: negatively_regulates GO:0006826 ! iron ion transport

[Term]
id: GO:0034758
name: positive regulation of iron ion transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of iron ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "activation of iron ion transport" NARROW []
synonym: "positive regulation of iron transport" EXACT []
synonym: "stimulation of iron ion transport" NARROW []
synonym: "up regulation of iron ion transport" EXACT []
synonym: "up-regulation of iron ion transport" EXACT []
synonym: "upregulation of iron ion transport" EXACT []
is_a: GO:0034756 ! regulation of iron ion transport
is_a: GO:0043270 ! positive regulation of ion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006826 ! iron ion transport
relationship: positively_regulates GO:0006826 ! iron ion transport

[Term]
id: GO:0034759
name: regulation of iron ion transmembrane transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of iron ions (Fe) from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "regulation of iron ion membrane transport" EXACT []
synonym: "regulation of transmembrane Fe transport" EXACT []
synonym: "regulation of transmembrane iron ion transport" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of transmembrane iron transport" EXACT []
is_a: GO:0034756 ! regulation of iron ion transport
is_a: GO:1904062 ! regulation of cation transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034755 ! iron ion transmembrane transport
relationship: regulates GO:0034755 ! iron ion transmembrane transport

[Term]
id: GO:0034760
name: negative regulation of iron ion transmembrane transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of iron ions from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "down regulation of transmembrane iron ion transport" EXACT []
synonym: "down-regulation of transmembrane iron ion transport" EXACT []
synonym: "downregulation of transmembrane iron ion transport" EXACT []
synonym: "inhibition of transmembrane iron ion transport" NARROW []
synonym: "negative regulation of iron ion membrane transport" EXACT []
synonym: "negative regulation of transmembrane iron ion transport" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of transmembrane iron transport" EXACT []
is_a: GO:0034757 ! negative regulation of iron ion transport
is_a: GO:0034759 ! regulation of iron ion transmembrane transport
is_a: GO:1904063 ! negative regulation of cation transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034755 ! iron ion transmembrane transport
relationship: negatively_regulates GO:0034755 ! iron ion transmembrane transport

[Term]
id: GO:0034761
name: positive regulation of iron ion transmembrane transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of iron ions from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "activation of transmembrane iron ion transport" NARROW []
synonym: "positive regulation of iron ion membrane transport" EXACT []
synonym: "positive regulation of transmembrane iron ion transport" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of transmembrane iron transport" EXACT []
synonym: "stimulation of transmembrane iron ion transport" NARROW []
synonym: "up regulation of transmembrane iron ion transport" EXACT []
synonym: "up-regulation of transmembrane iron ion transport" EXACT []
synonym: "upregulation of transmembrane iron ion transport" EXACT []
is_a: GO:0034758 ! positive regulation of iron ion transport
is_a: GO:0034759 ! regulation of iron ion transmembrane transport
is_a: GO:1904064 ! positive regulation of cation transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034755 ! iron ion transmembrane transport
relationship: positively_regulates GO:0034755 ! iron ion transmembrane transport

[Term]
id: GO:0034762
name: regulation of transmembrane transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." [GOC:mah]
synonym: "regulation of membrane transport" EXACT []
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0055085 ! transmembrane transport
relationship: regulates GO:0055085 ! transmembrane transport

[Term]
id: GO:0034763
name: negative regulation of transmembrane transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." [GOC:mah]
synonym: "down regulation of transmembrane transport" EXACT []
synonym: "down-regulation of transmembrane transport" EXACT []
synonym: "downregulation of transmembrane transport" EXACT []
synonym: "inhibition of transmembrane transport" NARROW []
synonym: "negative regulation of membrane transport" EXACT []
is_a: GO:0034762 ! regulation of transmembrane transport
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051051 ! negative regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0055085 ! transmembrane transport
relationship: negatively_regulates GO:0055085 ! transmembrane transport

[Term]
id: GO:0034764
name: positive regulation of transmembrane transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." [GOC:mah]
synonym: "activation of transmembrane transport" NARROW []
synonym: "positive regulation of membrane transport" EXACT []
synonym: "stimulation of transmembrane transport" NARROW []
synonym: "up regulation of transmembrane transport" EXACT []
synonym: "up-regulation of transmembrane transport" EXACT []
synonym: "upregulation of transmembrane transport" EXACT []
is_a: GO:0034762 ! regulation of transmembrane transport
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051050 ! positive regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0055085 ! transmembrane transport
relationship: positively_regulates GO:0055085 ! transmembrane transport

[Term]
id: GO:0034765
name: regulation of ion transmembrane transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." [GOC:mah]
synonym: "regulation of ion membrane transport" EXACT []
synonym: "regulation of transmembrane ion transport" EXACT [GOC:dph, GOC:tb]
is_a: GO:0034762 ! regulation of transmembrane transport
is_a: GO:0043269 ! regulation of ion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034220 ! ion transmembrane transport
relationship: regulates GO:0034220 ! ion transmembrane transport

[Term]
id: GO:0034766
name: negative regulation of ion transmembrane transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." [GOC:mah]
synonym: "down regulation of transmembrane ion transport" EXACT []
synonym: "down-regulation of transmembrane ion transport" EXACT []
synonym: "downregulation of transmembrane ion transport" EXACT []
synonym: "inhibition of transmembrane ion transport" NARROW []
synonym: "negative regulation of ion membrane transport" EXACT []
synonym: "negative regulation of transmembrane ion transport" EXACT [GOC:dph, GOC:tb]
is_a: GO:0034763 ! negative regulation of transmembrane transport
is_a: GO:0034765 ! regulation of ion transmembrane transport
is_a: GO:0043271 ! negative regulation of ion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034220 ! ion transmembrane transport
relationship: negatively_regulates GO:0034220 ! ion transmembrane transport

[Term]
id: GO:0034767
name: positive regulation of ion transmembrane transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." [GOC:mah]
synonym: "activation of transmembrane ion transport" NARROW []
synonym: "positive regulation of ion membrane transport" EXACT []
synonym: "positive regulation of transmembrane ion transport" EXACT []
synonym: "stimulation of transmembrane ion transport" NARROW []
synonym: "up regulation of transmembrane ion transport" EXACT []
synonym: "up-regulation of transmembrane ion transport" EXACT []
synonym: "upregulation of transmembrane ion transport" EXACT []
is_a: GO:0034764 ! positive regulation of transmembrane transport
is_a: GO:0034765 ! regulation of ion transmembrane transport
is_a: GO:0043270 ! positive regulation of ion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034220 ! ion transmembrane transport
relationship: positively_regulates GO:0034220 ! ion transmembrane transport

[Term]
id: GO:0034768
name: (E)-beta-ocimene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranyl diphosphate = (E)-beta-ocimene + diphosphate." [PMID:12624761]
xref: EC:4.2.3.-
xref: MetaCyc:RXN-5109
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0034769
name: basement membrane disassembly
namespace: biological_process
def: "The controlled breakdown of the basement membrane in the context of a normal process such as imaginal disc eversion." [GOC:sart, PMID:17301221]
comment: Note that this term has no relationship to 'membrane disassembly ; GO:0030397' because the basement membrane is not a lipid bilayer.
is_a: GO:0022617 ! extracellular matrix disassembly
is_a: GO:0071711 ! basement membrane organization

[Term]
id: GO:0034770
name: histone H4-K20 methylation
namespace: biological_process
def: "The modification of histone H4 by addition of one or more methyl groups to lysine at position 20 of the histone." [GOC:mah]
synonym: "histone H4 K20 methylation" EXACT []
synonym: "histone H4K20me" EXACT []
synonym: "histone lysine H4 K20 methylation" EXACT []
is_a: GO:0034968 ! histone lysine methylation

[Term]
id: GO:0034771
name: histone H4-K20 monomethylation
namespace: biological_process
def: "The modification of histone H4 by addition of one methyl group to lysine at position 20 of the histone." [GOC:mah]
synonym: "histone H4 K20 monomethylation" EXACT []
synonym: "histone lysine H4 K20 monomethylation" EXACT []
is_a: GO:0018026 ! peptidyl-lysine monomethylation
is_a: GO:0034770 ! histone H4-K20 methylation

[Term]
id: GO:0034772
name: histone H4-K20 dimethylation
namespace: biological_process
def: "The modification of histone H4 by addition of two methyl groups to lysine at position 20 of the histone." [GOC:mah]
synonym: "histone H4 K20 dimethylation" EXACT []
synonym: "histone lysine H4 K20 dimethylation" EXACT []
is_a: GO:0018027 ! peptidyl-lysine dimethylation
is_a: GO:0034770 ! histone H4-K20 methylation

[Term]
id: GO:0034773
name: histone H4-K20 trimethylation
namespace: biological_process
def: "The modification of histone H4 by addition of three methyl groups to lysine at position 20 of the histone." [GOC:mah]
synonym: "histone H4 K20 trimethylation" EXACT []
synonym: "histone lysine H4 K20 trimethylation" EXACT []
is_a: GO:0018023 ! peptidyl-lysine trimethylation
is_a: GO:0034770 ! histone H4-K20 methylation

[Term]
id: GO:0034774
name: secretory granule lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of a secretory granule." [GOC:rph]
is_a: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen
relationship: part_of GO:0030141 ! secretory granule

[Term]
id: GO:0034775
name: glutathione transmembrane transport
namespace: biological_process
def: "A process in which glutathione is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "glutathione membrane transport" EXACT []
synonym: "transmembrane glutathione transport" EXACT [GOC:dph, GOC:tb]
is_a: GO:0034635 ! glutathione transport
is_a: GO:0035443 ! tripeptide transmembrane transport
is_a: GO:0098656 ! anion transmembrane transport

[Term]
id: GO:0034776
name: response to histamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histamine stimulus. Histamine, the biogenic amine 2-(1H-imidazol-4-yl)ethanamine, is involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter." [CHEBI:18295, GOC:BHF, GOC:mah, GOC:vk]
synonym: "response to histamine stimulus" EXACT []
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound

[Term]
id: GO:0034777
name: recycling endosome lumen
namespace: cellular_component
def: "The volume enclosed by the membranes of a recycling endosome." [GOC:rph]
is_a: GO:0031904 ! endosome lumen
relationship: part_of GO:0055037 ! recycling endosome

[Term]
id: GO:0034778
name: 2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA = 4-isopropenyl-2-ketocyclohexane-1-carboxyl-CoA + 2 H+ + 2 e-." [UM-BBD_reactionID:r1003]
xref: EC:1.1.-.-
xref: UM-BBD_reactionID:r1003
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0034779
name: 4-isopropenyl-2-ketocyclohexane-1-carboxyl-CoA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-isopropenyl-2-ketocyclohexane-1-carboxyl-CoA + H2O = 3-isopropenylpimelyl-CoA." [UM-BBD_reactionID:r1004]
xref: EC:3.7.1.-
xref: UM-BBD_reactionID:r1004
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0034780
name: glyphosate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: glyphosate + OH- = glyoxylate + aminomethylphosphonic acid + H+ + 2 e-." [UM-BBD_reactionID:r0073]
xref: EC:1.5.-.-
xref: UM-BBD_reactionID:r0073
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0034781
name: N-cyclohexylformamide amidohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-cyclohexylformamide + OH- = cyclohexylamine + formate." [UM-BBD_reactionID:r1030]
xref: EC:3.5.1.-
xref: UM-BBD_reactionID:r1030
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0034782
name: dimethylmalonate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: dimethylmalonate + H+ = isobutyrate + CO2." [UM-BBD_reactionID:r1031]
xref: EC:4.1.1.-
xref: UM-BBD_reactionID:r1031
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0034783
name: pivalate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: pivalate + H+ + HSCoA + ATP = pivalyl-CoA + PPi + AMP." [UM-BBD_reactionID:r1032]
xref: EC:6.2.1.-
xref: UM-BBD_reactionID:r1032
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0034784
name: pivalyl-CoA mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: pivalyl-CoA = 3-methylbutyryl-CoA." [UM-BBD_reactionID:r1033]
xref: EC:5.4.99.-
xref: UM-BBD_reactionID:r1033
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0034785
name: salicylate 5-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: salicylate + O2 + NAD(P)H + H+ = gentisate + H2O + NAD(P)+." [UM-BBD_reactionID:r1034]
xref: EC:1.14.13.-
xref: MetaCyc:RXN-10446
xref: UM-BBD_reactionID:r1034
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0034786
name: 9-fluorenone-3,4-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 9-fluorenone + O2 + 2 H+ + 2 e- = 1-hydro-1,1a-dihydroxy-9-fluorenone." [UM-BBD_reactionID:r1039]
xref: EC:1.14.-.-
xref: UM-BBD_reactionID:r1039
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0034787
name: 1-hydro-1,1a-dihydroxy-9-fluorenone dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-hydro-1,1a-dihydroxy-9-fluorenone + H2O = 2,3-dihydroxy-2'-carboxybiphenyl + 3 H+ + 2 e-." [UM-BBD_reactionID:r1040]
xref: EC:1.3.-.-
xref: UM-BBD_reactionID:r1040
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0034788
name: 2,3-dihydroxy-2'-carboxybiphenyl 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-dihydroxy-2'-carboxybiphenyl + O2 = 2-hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate + H+." [UM-BBD_reactionID:r1041]
xref: EC:1.13.-.-
xref: UM-BBD_reactionID:r1041
is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen

[Term]
id: GO:0034789
name: 2-hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate + H2O = cis-2-hydroxypenta-2,4-dienoate + phthalate + H+." [UM-BBD_reactionID:r1042]
xref: EC:3.7.1.-
xref: UM-BBD_reactionID:r1042
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0034790
name: 3,4-dihydroxy-3,4-dihydrofluorene dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (+)-(3S,4R)-cis-3,4-dihydroxy-3,4-dihydrofluorene = 3,4-dihydroxyfluorene + 2 H+ + 2 e-." [UM-BBD_reactionID:r1043]
xref: EC:1.3.1.-
xref: UM-BBD_reactionID:r1043
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0034791
name: isobutylamine N-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: isobutylamine + NADPH + O2 = isobutylhydroxylamine + NADP+ + H2O." [UM-BBD_reactionID:r1053]
xref: EC:1.14.13.-
xref: UM-BBD_reactionID:r1053
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0034792
name: hypophosphite dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: hypophosphite + 2-oxoglutarate + O2 = succinate + phosphite + CO2." [UM-BBD_reactionID:r1058]
xref: EC:1.14.11.-
xref: UM-BBD_reactionID:r1058
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0034793
name: cyclopropanecarboxylate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyclopropanecarboxylate + CoASH = cyclopropanecarboxyl-CoA + OH-." [UM-BBD_reactionID:r1056]
xref: EC:6.2.1.-
xref: UM-BBD_reactionID:r1056
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0034794
name: cyclopropanecarboxyl-CoA decyclase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyclopropanecarboxyl-CoA = crotonoyl-CoA." [UM-BBD_reactionID:r1057]
xref: EC:5.5.1.-
xref: UM-BBD_reactionID:r1057
is_a: GO:0016872 ! intramolecular lyase activity

[Term]
id: GO:0034795
name: cyclohexane monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyclohexane + O2 + NAD(P)H + H+ = cyclohexanol + NAD(P)+ + H2O." [UM-BBD_reactionID:r1059]
synonym: "butane monooxygenase activity" RELATED []
synonym: "cyclohexane hydroxylase activity" EXACT [MetaCyc:RXN-8697]
xref: EC:1.14.15.-
xref: KEGG:R06945
xref: MetaCyc:RXN-8697
xref: UM-BBD_reactionID:r1059
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0034796
name: adipate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: adipate + CoASH = adipyl-CoA + OH-." [UM-BBD_reactionID:r1060]
xref: EC:6.2.1.-
xref: UM-BBD_reactionID:r1060
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0034797
name: fosfomycin 2-glutathione ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrogen (2R,3S)-3-methyloxiran-2-ylphosphonic acid + glutathione = hydrogen (1R,2R)-1-glutathio-2-hydroxypropylphosphonic acid." [UM-BBD_reactionID:r1073]
xref: EC:6.2.-.-
xref: UM-BBD_reactionID:r1073
is_a: GO:0016877 ! ligase activity, forming carbon-sulfur bonds

[Term]
id: GO:0034798
name: fosfomycin 2-L-cysteine ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrogen (2R,3S)-3-methyloxiran-2-ylphosphonic acid + L-cysteine = hydrogen (1R,2R)-1-L-cysteine-2-hydroxypropylphosphonic acid." [UM-BBD_reactionID:r1074]
xref: EC:6.2.-.-
xref: UM-BBD_reactionID:r1074
is_a: GO:0016877 ! ligase activity, forming carbon-sulfur bonds

[Term]
id: GO:0034799
name: dihydride TNP tautomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: TNP dihydride Meisenheimer complex (aci form) = TNP dihydride Meisenheimer complex (nitro form)." [UM-BBD_reactionID:r1070]
xref: EC:5.3.2.-
xref: UM-BBD_reactionID:r1070
is_a: GO:0016862 ! intramolecular oxidoreductase activity, interconverting keto- and enol-groups

[Term]
id: GO:0034800
name: trinitrophenol dihydride denitratase activity
namespace: molecular_function
def: "Catalysis of the reaction: trinitrophenol dihydride Meisenheimer complex (aci form) = 2,4-dinitrophenol hydride Meisenheimer complex + NO2. Trinitrophenol is also known as TNP and dinitrophenol is also known as DNP." [UM-BBD_reactionID:r1067]
synonym: "2,4,6-trinitrophenol dihydride denitratase activity" EXACT []
synonym: "TNP dihydride denitratase activity" EXACT []
xref: EC:1.7.99.-
xref: UM-BBD_reactionID:r1067
is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors

[Term]
id: GO:0034801
name: 2,4-dinitrocyclohexanone hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4-dinitrocyclohexanone + OH- = 4,6-dinitrohexanoate." [UM-BBD_reactionID:r1069]
xref: EC:3.7.1.-
xref: UM-BBD_reactionID:r1069
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0034802
name: branched-chain dodecylbenzene sulfonate monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: branched-chain dodecylbenzene sulfonate + 1/2 O2 + H+ = sulfurous acid + branched-chain dodecyl-4-hydroxy-benzene + sulfite." [UM-BBD_reactionID:r1079]
xref: EC:1.14.13.-
xref: UM-BBD_reactionID:r1079
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0034803
name: 3-hydroxy-2-naphthoate 2,3-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxy-2-naphthoate + O2 = (3E)-3-[(6Z)-6-(carboxymethylene)cyclohexa-2,4-dien-1-ylidene]-2-oxopropanate." [UM-BBD_reactionID:r1104]
xref: EC:1.13.11.-
xref: UM-BBD_reactionID:r1104
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0034804
name: benzo(a)pyrene 11,12-epoxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-11,12-epoxide." [UM-BBD_reactionID:r1119]
xref: EC:1.14.99.-
xref: UM-BBD_reactionID:r1119
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0034805
name: benzo(a)pyrene-trans-11,12-dihydrodiol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzo(a)pyrene-trans-11,12-dihydrodiol = 11,12-dihydroxybenzo(a)pyrene + 2 H+ + 2 e-." [UM-BBD_reactionID:r1121]
xref: EC:1.3.1.-
xref: UM-BBD_reactionID:r1121
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0034806
name: benzo(a)pyrene 11,12-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-11,12-dihydrodiol." [UM-BBD_reactionID:r1124]
xref: EC:1.13.11.-
xref: UM-BBD_reactionID:r1124
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0034807
name: 4,5-dihydroxybenzo(a)pyrene methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4,5-dihydroxybenzo(a)pyrene + C1 unit = hydroxymethoxybenzo(a)pyrene." [UM-BBD_reactionID:r1131]
xref: EC:2.1.1.-
xref: UM-BBD_reactionID:r1131
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0034808
name: benzo(a)pyrene 4,5-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-4,5-dihydrodiol." [UM-BBD_reactionID:r1126]
xref: EC:1.13.11.-
xref: UM-BBD_reactionID:r1126
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0034809
name: benzo(a)pyrene-cis-4,5-dihydrodiol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzo(a)pyrene-cis-4,5-dihydrodiol = 4,5-dihydroxybenzo(a)pyrene + H2." [UM-BBD_reactionID:r1127]
xref: EC:1.3.1.-
xref: UM-BBD_reactionID:r1127
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0034810
name: 4,5-dihydroxybenzo(a)pyrene dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4,5-dihydroxybenzo(a)pyrene + O2 = 4,5-chrysenedicarboxylate." [UM-BBD_reactionID:r1128]
xref: EC:1.13.11.-
xref: UM-BBD_reactionID:r1128
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0034811
name: benzo(a)pyrene 9,10-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-9,10-dihydrodiol." [UM-BBD_reactionID:r1132]
xref: EC:1.13.11.-
xref: UM-BBD_reactionID:r1132
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0034812
name: 9,10-dihydroxybenzo(a)pyrene dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 9,10-dihydroxybenzo(a)pyrene + O2 = cis-4-(8-hydroxypyren-7-yl)-2-oxobut-3-enoate." [UM-BBD_reactionID:r1134]
xref: EC:1.13.11.-
xref: UM-BBD_reactionID:r1134
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0034813
name: benzo(a)pyrene 7,8-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-7,8-dihydrodiol." [UM-BBD_reactionID:1137]
xref: EC:1.13.11.-
xref: UM-BBD_reactionID:r1137
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0034814
name: 7,8-dihydroxy benzo(a)pyrene dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzo(a)pyrene-cis-7,8-dihydrodiol + O2 = cis-4-(7-hydroxypyren-8-yl)-2-oxobut-3-enoate." [UM-BBD_reactionID:r1138]
xref: EC:1.13.11.-
xref: UM-BBD_reactionID:r1138
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0034815
name: cis-4-(8-hydroxypyren-7-yl)-2-oxobut-3-enoate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-4-(8-hydroxypyren-7-yl)-2-oxobut-3-enoate = 10-oxabenzo(def)chrysen-9-one + formate + H+." [UM-BBD_reactionID:r1135]
xref: EC:4.1.3.-
xref: UM-BBD_reactionID:r1135
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0034816
name: anthracene 9,10-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: anthracene + 2 H2O = cis-9,10-dihydroanthracene-9,10-diol." [UM-BBD_reactionID:r1141]
xref: EC:1.14.-.-
xref: UM-BBD_reactionID:r1141
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0034817
name: cis-9,10-dihydroanthracene-9,10-diol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-9,10-dihydroanthracene-9,10-diol = 9,10-anthraquinone + 4 H+ + 4 e-." [UM-BBD_reactionID:r1144]
xref: EC:1.1.-.-
xref: UM-BBD_reactionID:r1144
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0034818
name: ADD 9alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: androsta-1,4-diene-3,17-dione + reduced ferredoxin + O2 = 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + H2O + oxidized ferredoxin." [UM-BBD_reactionID:r1149]
xref: EC:1.14.15.-
xref: UM-BBD_reactionID:r1149
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0034819
name: 3-HSA hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + NADPH + H+ + O2 = 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + NADP+ + H2O." [UM-BBD_reactionID:r1150]
xref: EC:1.14.13.-
xref: UM-BBD_reactionID:r1150
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0034820
name: 4,9-DSHA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3E,1Z)-4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate + H2O = (2E,4E)-2-hydroxyhexa-2,4-dienoate + 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oate + H+." [UM-BBD_reactionID:r1152]
xref: EC:3.7.1.-
xref: UM-BBD_reactionID:r1152
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0034821
name: citronellol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: citronellol + NAD+ = citronellal + NADH + H+." [UM-BBD_reactionID:r1155]
xref: EC:1.1.-.-
xref: UM-BBD_reactionID:r1155
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0034822
name: citronellal dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: citronellal + NAD+ + OH- = citronellate + NADH + H+." [UM-BBD_reactionID:r1156]
xref: EC:1.2.1.-
xref: UM-BBD_reactionID:r1156
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0034823
name: citronellyl-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: citronellate + CoASH + ATP = citronellyl-CoA + AMP + PPi." [UM-BBD_reactionID:r1157]
xref: EC:6.2.1.-
xref: UM-BBD_reactionID:r1157
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0034824
name: citronellyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: citronellyl-CoA + NAD+ = cis-geranyl-CoA + NADH + H+." [UM-BBD_reactionID:r1159]
xref: EC:1.3.1.-
xref: UM-BBD_reactionID:r1159
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0034825
name: tetralin ring-hydroxylating dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: tetralin + O2 + NADH + H+ = cis-1,2-dihydroxy-1,2,5,6,7,8-hexahydronaphthalene + NAD+." [UM-BBD_reactionID:r1169]
xref: EC:1.14.12.-
xref: UM-BBD_reactionID:r1169
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0034826
name: 1,2-dihydroxy-1,2,5,6,7,8-hexyhadronaphthalene dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-1,2-dihydroxy-1,2,5,6,7,8-hexahydronaphthalene + NAD+ = 1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene + NADH + H+." [UM-BBD_reactionID:r1170]
xref: EC:1.3.-.-
xref: UM-BBD_reactionID:r1170
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0034827
name: 1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene + O2 = 4-(2-oxocyclohexyl)-2-hydroxy-buta-2,4-dienoate + H+." [UM-BBD_reactionID:r1171]
xref: EC:1.13.11.-
xref: UM-BBD_reactionID:r1171
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0034828
name: 4-(2-oxocyclohexyl)-2-hydroxy-buta-2,4-dienoate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-(2-oxocyclohexyl)-2-hydroxy-buta-2,4-dienoate + H2O = 2-hydroxydec-2,4-diene-1,10-dioate + H+." [UM-BBD_reactionID:r1172]
xref: EC:3.7.1.-
xref: UM-BBD_reactionID:r1172
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0034829
name: 2-hydroxydec-2,4-diene-1,10-dioate hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxydec-2,4-diene-1,10-dioate + H2O = (2Z)-2,4-dihydroxydec-2-enedioate." [UM-BBD_reactionID:r1172]
xref: EC:4.2.1.-
xref: UM-BBD_reactionID:r1172
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0034830
name: (2Z)-2,4-dihydroxydec-2-enedioate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2Z)-2,4-dihydroxydec-2-enedioate = pyruvate + 7-oxoheptanoate." [UM-BBD_reactionID:r1174]
xref: EC:4.1.3.-
xref: UM-BBD_reactionID:r1174
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0034831
name: (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-1,2,3,4-tetrahydronaphthol = 1,2,3,4-tetrahydronaphthalone + 2 H+ + 2 e-." [UM-BBD_reactionID:r1176]
xref: EC:1.1.1.-
xref: UM-BBD_reactionID:r1176
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0034832
name: geranial dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranial + NAD+ + OH- = geranylate + NADH + H+." [UM-BBD_reactionID:r1164]
xref: EC:1.2.1.-
xref: UM-BBD_reactionID:r1164
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0034833
name: geranylate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranylate + CoASH = trans-geranyl-CoA + OH-." [UM-BBD_reactionID:r1165]
xref: EC:2.8.3.-
xref: UM-BBD_reactionID:r1165
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0034834
name: 2-mercaptobenzothiazole dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-mercaptobenzothiazole + O2 + 2 H+ + 2 e- = 2-mercaptobenzothiazole-cis-6,7-dihydrodiol." [UM-BBD_reactionID:r1177]
xref: EC:1.13.11.-
xref: UM-BBD_reactionID:r1177
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0034835
name: 2-mercaptobenzothiazole monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-mercaptobenzothiazole + 1/2 O2 = 6-hydroxy-2-mercaptobenzothiazole." [UM-BBD_reactionID:r1178]
xref: EC:1.13.12.-
xref: UM-BBD_reactionID:r1178
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)

[Term]
id: GO:0034836
name: 6-hydroxy-2-mercaptobenzothiazole monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-hydroxy-2-mercaptobenzothiazole + 1/2 O2 = 6,7-dihydroxy-2-mercaptobenzothiazole." [UM-BBD_reactionID:r1181]
xref: EC:1.13.12.-
xref: UM-BBD_reactionID:r1181
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)

[Term]
id: GO:0034837
name: 2-mercaptobenzothiazole-cis-6,7-dihydrodiol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-mercaptobenzothiazole-cis-6,7-dihydrodiol = 6,7-dihydroxy-2-mercaptobenzothiazole + 2 H+ + 2 e-." [UM-BBD_reactionID:r1179]
xref: EC:1.3.-.-
xref: UM-BBD_reactionID:r1179
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0034838
name: menthone dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (-)-(2S,5R)-menthone + NAD+ = (5R)-menth-2-enone + NADH + H+." [UM-BBD_reactionID:r1183]
xref: EC:1.3.1.-
xref: UM-BBD_reactionID:r1183
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0034839
name: menth-2-enone hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (5R)-menth-2-enone + H2O = (5R)-3-hydroxymenthone." [UM-BBD_reactionID:r1184]
xref: EC:4.2.1.-
xref: UM-BBD_reactionID:r1184
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0034840
name: 3-hydroxymenthone dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (5R)-3-hydroxymenthone + NAD+ = mentha-1,3-dione + NADH + H+." [UM-BBD_reactionID:r1185]
xref: EC:1.1.1.-
xref: UM-BBD_reactionID:r1185
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0034841
name: mentha-1,3-dione-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: mentha-1,3-dione + CoASH = 3,7-dimethyl-5-oxo-octyl-CoA." [UM-BBD_reactionID:r1186]
xref: EC:6.2.1.-
xref: UM-BBD_reactionID:r1186
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0034842
name: thiophene-2-carboxylate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: thiophene-2-carboxylate + ATP + CoASH = thiophene-2-carboxyl-CoA + AMP + PPi." [UM-BBD_reactionID:r1234]
xref: EC:6.2.1.-
xref: UM-BBD_reactionID:r1234
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0034843
name: 2-oxoglutaryl-CoA thioesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutaryl-CoA + OH- = 2-oxoglutarate + CoASH." [UM-BBD_reactionID:r1238]
xref: EC:3.1.2.-
xref: UM-BBD_reactionID:r1238
is_a: GO:0016790 ! thiolester hydrolase activity

[Term]
id: GO:0034844
name: naphthyl-2-methyl-succinate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: naphthyl-2-methyl-succinate + succinyl-CoA = naphthyl-2-methyl-succinyl-CoA + succinate." [UM-BBD_reactionID:r1256]
xref: EC:2.8.3.-
xref: UM-BBD_reactionID:r1256
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0034845
name: naphthyl-2-methyl-succinyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: naphthyl-2-methyl-succinyl-CoA = naphthyl-2-methylene-succinyl-CoA + 2 H+ + 2 e-." [UM-BBD_reactionID:r1258]
xref: EC:1.3.99.-
xref: UM-BBD_reactionID:r1258
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0034846
name: naphthyl-2-methylene-succinyl-CoA lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: naphthyl-2-methylene-succinyl-CoA + H2O = naphthyl-2-hydroxymethyl-succinyl-CoA." [UM-BBD_reactionID:r1259]
xref: EC:4.2.1.-
xref: UM-BBD_reactionID:r1259
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0034847
name: naphthyl-2-hydroxymethyl-succinyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: naphthyl-2-hydroxymethyl-succinyl-CoA = naphthyl-2-oxomethyl-succinyl-CoA + 2 H+ + 2 e-." [UM-BBD_reactionID:r1260]
xref: EC:1.1.-.-
xref: UM-BBD_reactionID:r1260
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0034848
name: naphthyl-2-oxomethyl-succinyl-CoA succinyl transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: naphthyl-2-oxomethyl-succinyl-CoA + CoASH = 2-naphthoyl-CoA + succinyl-CoA." [UM-BBD_reactionID:r1261]
xref: EC:2.3.1.-
xref: UM-BBD_reactionID:r1261
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0034849
name: 2-naphthoate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-naphthoyl-CoA + OH- = 2-naphthoate + CoASH." [UM-BBD_reactionID:r1262]
xref: EC:2.8.3.-
xref: UM-BBD_reactionID:r1262
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0034850
name: isooctane monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: isooctane + 1/2 O2 = 2,4,4-trimethyl-1-pentanol." [UM-BBD_reactionID:r1269]
xref: EC:1.13.12.-
xref: UM-BBD_reactionID:r1269
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)

[Term]
id: GO:0034851
name: 2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4,4-trimethyl-3-oxopentanoyl-CoA + CoASH = pivalyl-CoA + propanoyl-CoA." [UM-BBD_reactionID:r1274]
xref: EC:2.3.1.-
xref: UM-BBD_reactionID:r1274
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0034852
name: 4,4-dimethyl-3-oxopentanal dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4,4-dimethyl-3-oxopentanal + H2O = 4,4-dimethyl-3-oxopentanoate + 3 H+ + 2 e-." [UM-BBD_reactionID:r1309]
xref: EC:1.2.-.-
xref: UM-BBD_reactionID:r1309
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0034853
name: 2,4,4-trimethyl-3-oxopentanoate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4,4-trimethyl-3-oxopentanoate + H+ = 2,2-dimethyl-3-pentanone + CO2." [UM-BBD_reactionID:r1278]
xref: EC:4.1.1.-
xref: UM-BBD_reactionID:r1278
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0034854
name: 4,4-dimethyl-3-oxopentanoate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4,4-dimethyl-3-oxopentanoate + H+ = 3,3-dimethyl-2-butanone + CO2." [UM-BBD_reactionID:r1280]
xref: EC:4.1.1.-
xref: UM-BBD_reactionID:r1280
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0034855
name: 4-AD 9alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: androst-4-ene-3,17-dione + O2 + 2 H+ + 2 e- = 9alpha-hydroxy-4-androstene-3,17-dione + H2O." [UM-BBD_reactionID:r1153]
xref: EC:1.14.15.-
xref: UM-BBD_reactionID:r1153
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0034856
name: 2-hydroxyhexa-2,4-dienoate hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2E,4E)-2-hydroxyhexa-2,4-dienoate + H2O = 4-hydroxy-2-oxohexanoate." [UM-BBD_reactionID:r1281]
xref: EC:4.2.1.-
xref: UM-BBD_reactionID:r1281
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0034857
name: 2-(methylthio)benzothiazole monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-(methylthio)benzothiazole + 1/2 O2 = 2-(methylsulfinyl)benzothiazole." [UM-BBD_reactionID:r1287]
xref: EC:1.14.-.-
xref: UM-BBD_reactionID:r1287
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0034858
name: 2-hydroxybenzothiazole monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxybenzothiazole + 1/2 O2 = 2,6-dihydroxybenzothiazole." [UM-BBD_reactionID:r1291]
xref: EC:1.14.-.-
xref: UM-BBD_reactionID:r1291
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0034859
name: benzothiazole monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzothiazole + 1/2 O2 = 2-hydroxybenzothiazole." [UM-BBD_reactionID:r1292]
xref: EC:1.14.-.-
xref: UM-BBD_reactionID:r1292
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0034860
name: 2-mercaptobenzothiazole desulfurase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-mercaptobenzothiazole + reduced acceptor = benzothiazole + hydrogen sulfide + oxidized acceptor." [UM-BBD_reactionID:r1288]
xref: EC:4.4.1.-
xref: UM-BBD_reactionID:r1288
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0034861
name: benzothiazole-2-sulfonate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzothiazole-2-sulfonate + H2O = 2-hydroxybenzothiazole + HSO3-." [UM-BBD_reactionID:r1290]
xref: EC:3.13.1.-
xref: UM-BBD_reactionID:r1290
is_a: GO:0046508 ! hydrolase activity, acting on carbon-sulfur bonds

[Term]
id: GO:0034862
name: 2,6-dihydroxybenzothiazole monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,6-dihydroxybenzothiazole + 1/2 O2 = 2,6,7-trihydroxybenzothiazole." [UM-BBD_reactionID:r1294]
xref: EC:1.14.-.-
xref: UM-BBD_reactionID:r1294
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0034863
name: 2,4,4-trimethyl-1-pentanol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4,4-trimethyl-1-pentanol = 2,4,4-trimethylpentanal + 2 H+ + 2 e-." [UM-BBD_reactionID:r1270]
xref: EC:1.1.-.-
xref: UM-BBD_reactionID:r1270
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0034864
name: 2,4,4-trimethylpentanal dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4,4-trimethylpentanal + H2O = 2,4,4-trimethylpentanoate + 3 H+ + 2 e-." [UM-BBD_reactionID:r1275]
xref: EC:1.2.-.-
xref: UM-BBD_reactionID:r1275
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0034865
name: 2,4,4-trimethylpentanoate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4,4-trimethylpentanoate + CoASH = 2,4,4-trimethylpentanoyl-CoA + OH-." [UM-BBD_reactionID:r1271]
xref: EC:6.2.1.-
xref: UM-BBD_reactionID:r1271
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0034866
name: 2,4,4-trimethylpentanoyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4,4-trimethylpentanoyl-CoA = 2,4,4-trimethylpent-2-enoyl-CoA + 2 H+ + 2 e-." [UM-BBD_reactionID:r1276]
xref: EC:1.3.-.-
xref: UM-BBD_reactionID:r1276
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0034867
name: 2,4,4-trimethylpent-2-enoyl-CoA hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4,4-trimethylpent-2-enoyl-CoA + H2O = 2,4,4-trimethyl-3-hydroxypentanoyl-CoA." [UM-BBD_reactionID:r1277]
xref: EC:4.2.1.-
xref: UM-BBD_reactionID:r1277
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0034868
name: 2,4,4-trimethyl-3-hydroxypentanoyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4,4-trimethyl-3-hydroxypentanoyl-CoA = 2,4,4-trimethyl-3-oxopentanoyl-CoA + 2 H+ + 2 e-." [UM-BBD_reactionID:r1273]
xref: EC:1.1.-.-
xref: UM-BBD_reactionID:r1273
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0034869
name: 2,4,4-trimethyl-3-oxopentanoyl-CoA thioesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4,4-trimethyl-3-oxopentanoyl-CoA + OH- = 2,4,4-trimethyl-3-oxopentanoate + CoASH." [UM-BBD_reactionID:r1307]
xref: EC:3.1.2.-
xref: UM-BBD_reactionID:r1307
is_a: GO:0016790 ! thiolester hydrolase activity

[Term]
id: GO:0034870
name: pinacolone 5-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,2-dimethyl-3-pentanone + 1/2 O2 = 1-hydroxy-4,4-dimethylpentan-3-one." [UM-BBD_reactionID:r12979]
xref: EC:1.14.-.-
xref: UM-BBD_reactionID:r12979
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0034871
name: 1-hydroxy-4,4-dimethylpentan-3-one dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-hydroxy-4,4-dimethylpentan-3-one = 4,4-dimethyl-3-oxopentanal + 2 H+ + 2 e-." [UM-BBD_reactionID:r1308]
xref: EC:1.1.-.-
xref: UM-BBD_reactionID:r1308
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0034872
name: trans-geranyl-CoA isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-geranyl-CoA = cis-geranyl-CoA." [UM-BBD_reactionID:r1310]
xref: EC:5.2.1.-
xref: UM-BBD_reactionID:r1310
is_a: GO:0016859 ! cis-trans isomerase activity

[Term]
id: GO:0034873
name: thioacetamide S-oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: thioacetamide + O2 + 2 H+ + 2 e- = thioacetamide S-oxide + H2O." [UM-BBD_reactionID:r1312]
xref: EC:1.14.-.-
xref: UM-BBD_reactionID:r1312
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0034874
name: thioacetamide S-oxide S-oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: thioacetamide S-oxide + O2 + 2 H+ + 2 e- = thioacetamide S,S-dioxide + H2O." [UM-BBD_reactionID:r1313]
xref: EC:1.14.-.-
xref: UM-BBD_reactionID:r1313
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0034875
name: caffeine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: caffeine + O2 + 2 H+ + 2 e- = 1,3,7-trimethyluric acid + H2O." [UM-BBD_reactionID:r1321]
xref: EC:1.17.5.-
xref: UM-BBD_reactionID:r1321
is_a: GO:0033695 ! oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor

[Term]
id: GO:0034876
name: isonicotinic acid hydrazide hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: isoniazid + H2O = isonicotinate + hydrazine." [UM-BBD_reactionID:r1336]
xref: EC:3.5.1.-
xref: UM-BBD_reactionID:r1336
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0034877
name: isonicotinate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: isonicotinate + acceptor + H2O = 2-hydroxyisonicotinate + reduced acceptor." [UM-BBD_reactionID:r1337]
xref: EC:1.15.-.-
xref: UM-BBD_reactionID:r1337
is_a: GO:0016721 ! oxidoreductase activity, acting on superoxide radicals as acceptor

[Term]
id: GO:0034878
name: 2-hydroxyisonicotinate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxyisonicotinate + acceptor + H2O = citrazinate + reduced acceptor." [UM-BBD_reactionID:r1338]
xref: EC:1.15.-.-
xref: UM-BBD_reactionID:r1338
is_a: GO:0016721 ! oxidoreductase activity, acting on superoxide radicals as acceptor

[Term]
id: GO:0034879
name: 2,3,6-trihydroxyisonicotinate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3,6-trihydroxyisonicotinate = 2,3,6-trihydroxypyridine + CO2." [UM-BBD_reactionID:r1340]
xref: EC:4.1.1.-
xref: UM-BBD_reactionID:r1340
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0034880
name: citrazinate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: citrazinate + H2O = 2,3,6-trihydroxyisonicotinate + 2 H+ + 2 e-." [UM-BBD_reactionID:r1339]
xref: EC:1.15.-.-
xref: UM-BBD_reactionID:r1339
is_a: GO:0016721 ! oxidoreductase activity, acting on superoxide radicals as acceptor

[Term]
id: GO:0034881
name: citrazinate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: citrazinate + H2O = cis-aconitamide." [UM-BBD_reactionID:r1343]
xref: EC:3.5.2.-
xref: UM-BBD_reactionID:r1343
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0034882
name: cis-aconitamide amidase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-aconitamide + H2O = cis-aconitate + HN3." [UM-BBD_reactionID:r1344]
xref: EC:3.5.1.-
xref: UM-BBD_reactionID:r1344
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0034883
name: obsolete isonicotinate reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: isonicotinate + 2 H+ + 2 e- = 1,4-dihydroisonicotinate." [UM-BBD_reactionID:r1347]
comment: This term was made obsolete because it was derived from a UM-BBD enzyme entry that has been deleted, and no other information can be found to suggest that it is a naturally occurring activity.
synonym: "isonicotinate reductase activity" EXACT []
xref: EC:1.3.-.-
xref: UM-BBD_enzymeID:e0841
is_obsolete: true
consider: GO:0016627

[Term]
id: GO:0034884
name: obsolete gamma-N-formylaminovinylacetaldehyde dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: gamma-N-formylaminovinylacetaldehyde + H2O = gamma-N-formylaminovinylacetate + 2 H+ + 2 e-." [UM-BBD_reactionID:r1349]
comment: This term was made obsolete because it was derived from a UM-BBD enzyme entry that has been deleted, and no other information can be found to suggest that it is a naturally occurring activity.
synonym: "gamma-N-formylaminovinylacetaldehyde dehydrogenase activity" EXACT []
xref: EC:1.2.99.-
xref: UM-BBD_enzymeID:e0842
is_obsolete: true
consider: GO:0016903

[Term]
id: GO:0034885
name: gamma-N-formylaminovinylacetate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: gamma-N-formylaminovinylacetate + H2O = gamma-aminovinylacetate + HCOOH." [UM-BBD_reactionID:r1350]
xref: EC:3.5.1.-
xref: UM-BBD_reactionID:r1350
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0034886
name: gamma-aminovinylacetate deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: gamma-aminovinylacetate + H2O = succinic semialdehyde + NH3." [UM-BBD_reactionID:r1351]
xref: EC:3.5.99.-
xref: UM-BBD_reactionID:r1351
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

[Term]
id: GO:0034887
name: obsolete 1,4-dihydroisonicotinate 2,3-dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1,4-dihydroisonicotinate + O2 = gamma-N-formylaminovinylacetaldehyde + CO2." [UM-BBD_reactionID:r1348]
comment: This term was made obsolete because it was derived from a UM-BBD enzyme entry that has been deleted, and no other information can be found to suggest that it is a naturally occurring activity.
synonym: "1,4-dihydroisonicotinate 2,3-dioxygenase activity" EXACT []
xref: EC:1.13.11.-
xref: UM-BBD_enzymeID:e0845
is_obsolete: true
consider: GO:0016702

[Term]
id: GO:0034888
name: endosulfan monooxygenase I activity
namespace: molecular_function
def: "Catalysis of the reaction: endosulfan + O2 + 2 H+ + 2 e- = endosulfan sulfate + H2O." [UM-BBD_reactionID:r1382]
xref: EC:1.14.-.-
xref: UM-BBD_reactionID:r1382
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0034889
name: endosulfan hemisulfate sulfatase activity
namespace: molecular_function
def: "Catalysis of the reaction: endosulfan hemisulfate + H2O = endosulfan monoalcohol + 2 H+ + sulfate." [UM-BBD_reactionID:r1384]
xref: EC:3.1.6.-
xref: UM-BBD_reactionID:r1384
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0034890
name: endosulfan diol hydrolyase (cyclizing) activity
namespace: molecular_function
def: "Catalysis of the reaction: endosulfan diol = endosulfan ether + H2O." [UM-BBD_reactionID:r1386]
xref: EC:4.2.1.-
xref: UM-BBD_reactionID:r1386
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0034891
name: endosulfan diol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: endosulfan diol = endosulfan hydroxyether + 2 H+ + 2 e-." [UM-BBD_reactionID:r1388]
xref: EC:1.1.-.-
xref: UM-BBD_reactionID:r1388
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0034892
name: endosulfan lactone lactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: endosulfan lactone + H2O = endosulfan hydroxycarboxylate + H+." [UM-BBD_reactionID:r1389]
xref: EC:3.1.1.-
xref: UM-BBD_reactionID:r1389
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0034893
name: N-nitrodimethylamine hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-nitrodimethylamine + O2 + 2 H+ + 2 e- = N-nitromethylamine + formaldehyde + H2O." [UM-BBD_reactionID:r1395]
xref: EC:1.14.-.-
xref: UM-BBD_reactionID:r1395
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0034894
name: 4-hydroxypyridine-3-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxypyridine + O2 + H+ + NADPH = pyridine-3,4-diol + H2O + NADP+." [UM-BBD_reactionID:r1397]
xref: EC:1.14.13.-
xref: UM-BBD_reactionID:r1397
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0034895
name: pyridine-3,4-diol dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: pryidine-3,4-diol + O2 = 3-(N-formyl)-formiminopyruvate." [UM-BBD_reactionID:r1398]
xref: EC:1.13.11.-
xref: UM-BBD_reactionID:r1398
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0034896
name: 3-formiminopyruvate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-formiminopyruvate + H2O = 3-formylpyruvate + HN3." [UM-BBD_reactionID:r1400]
xref: EC:3.5.99.-
xref: UM-BBD_reactionID:r1400
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

[Term]
id: GO:0034897
name: 4-(1-ethyl-1,4-dimethyl-pentyl)phenol monoxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-(1-ethyl-1,4-dimethyl-pentyl)phenol + O2 + 2 H+ + 2 e- = hydroquinone + 3,6-dimethylheptan-3-ol." [UM-BBD_reactionID:r1358]
xref: EC:1.14.-.-
xref: UM-BBD_reactionID:r1358
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0034898
name: hexadecyltrimethylammonium chloride monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: hexadecyltrimethylammonium chloride + NAD(P)H + H+ + O2 = trimethylamine + hexadecanal + NAD(P)+ + H2O." [UM-BBD_reactionID:r1373]
xref: EC:1.13.12.-
xref: UM-BBD_reactionID:r1373
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)

[Term]
id: GO:0034899
name: trimethylamine monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: N,N,N-trimethylamine + NADPH + H+ + O2 = N,N,N-trimethylamine N-oxide + NADP+ + H2O." [EC:1.14.13.148, UM-BBD_reactionID:r1407]
xref: EC:1.14.13.148
xref: KEGG:R05623
xref: RHEA:31982
xref: UM-BBD_reactionID:r1407
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0034900
name: 3-(N-formyl)-formiminopyruvate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-(N-formyl)-formiminopyruvate + H2O = 3-formiminopyruvate + formate." [UM-BBD_reactionID:r1399]
xref: EC:3.5.99.-
xref: UM-BBD_reactionID:r1399
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

[Term]
id: GO:0034901
name: endosulfan hydroxyether dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: endosulfan hydroxyether = endosulfan lactone + 2 H+ + 2 e-." [UM-BBD_reactionID:r1411]
xref: EC:1.1.-.-
xref: UM-BBD_reactionID:r1411
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0034902
name: endosulfan sulfate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: endosulfan sulfate + H2O = endosulfan diol + sulfite." [UM-BBD_reactionID:r1387]
xref: EC:3.1.6.-
xref: UM-BBD_reactionID:r1387
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0034903
name: endosulfan ether monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: endosulfan ether + O2 + 2 H+ + 2 e- = endosulfan hydroxyether + H2O." [UM-BBD_reactionID:r1413]
xref: EC:1.14.-.-
xref: UM-BBD_reactionID:r1413
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0034904
name: 5-chloro-2-oxopent-4-enoate hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-chloro-2-oxopent-4-enoate + H2O = 5-chloro-4-hydroxy-2-oxopentanate." [UM-BBD_reactionID:r1436]
xref: EC:4.2.1.-
xref: UM-BBD_reactionID:r1436
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0034905
name: 5-chloro-4-hydroxy-2-oxopentanate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-chloro-4-hydroxy-2-oxopentanate = pyruvate + chloroacetaldehyde." [UM-BBD_reactionID:r1437]
xref: EC:4.1.3.-
xref: UM-BBD_reactionID:r1437
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0034906
name: N-isopropylaniline 1,2-dixoxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-isopropylaniline + O2 + 2 H+ + NADH = catechol + NAD+ + isopropylamine." [UM-BBD_reactionID:r0721]
xref: EC:1.14.12.-
xref: UM-BBD_reactionID:r0721
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0034907
name: acetanilide 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetanilide + O2 + 2 H+ + NADH = catechol + NAD+ + acetamide." [UM-BBD_reactionID:r0723]
xref: EC:1.14.12.-
xref: UM-BBD_reactionID:r0723
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0034908
name: 2-chloro-N-isopropylacetanilide 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-chloro-N-isopropylacetanilide + O2 + 2 H+ + NADH = 2-chloro-N-isopropylacetamide + catechol + NAD+." [UM-BBD_reactionID:r0724]
xref: EC:1.14.12.-
xref: UM-BBD_reactionID:r0724
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0034909
name: 6-hydroxypseudooxynicotine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-hydroxypseudooxynicotine + H2O + OH- = 6-hydroxy-3-succinoylpyridine + 4 H+ + 4 e- + methylamine." [UM-BBD_reactionID:r1441]
xref: EC:1.5.-.-
xref: UM-BBD_reactionID:r1441
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0034910
name: 6-hydroxy-3-succinoylpyridine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-hydroxy-3-succinoylpyridine + H2O = succinic semialdehyde + 2,5-dihydroxypyridine." [UM-BBD_reactionID:r1442]
xref: EC:3.7.1.-
xref: UM-BBD_reactionID:r1442
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0034911
name: phthalate 3,4-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: phthalate + O2 + NADH + H+ = phthalate 3,4-cis-dihydrodiol + NAD+." [UM-BBD_reactionID:r1444]
xref: EC:1.14.12.-
xref: UM-BBD_reactionID:r1444
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0034912
name: phthalate 3,4-cis-dihydrodiol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: phthalate 3,4-cis-dihydrodiol + NAD+ = 3,4-dihydroxyphthalate + NADH + H+." [UM-BBD_reactionID:r1445]
xref: EC:1.3.1.-
xref: MetaCyc:RXN5F9-56
xref: UM-BBD_reactionID:r1445
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0034914
name: trinitrophenol hydride denitratase activity
namespace: molecular_function
def: "Catalysis of the reaction: trinitrophenol hydride Meisenheimer complex = 2,4-dinitrophenol + nitrite. Trinitrophenol is also known as TNP." [UM-BBD_reactionID:r1448]
synonym: "2,4,6-trinitrophenol hydride denitratase activity" EXACT []
synonym: "TNP hydride denitratase activity" EXACT []
xref: EC:1.7.99.-
xref: UM-BBD_reactionID:r1448
is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors

[Term]
id: GO:0034915
name: 2-methylhexanoyl-CoA C-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-methyl-3-oxooctanoyl-CoA + CoA = acetyl-CoA + 2-methylhexanoyl-CoA." [UM-BBD_reactionID:r0927]
xref: EC:2.3.1.-
xref: UM-BBD_reactionID:r0927
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0034916
name: 2-methylhexanoyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-methylhexanoyl-CoA = 2-methylhex-2-enoyl-CoA + 2 H+ + e-." [UM-BBD_reactionID:r0928]
xref: EC:1.3.99.-
xref: UM-BBD_reactionID:r0928
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0034917
name: 2-methylhex-2-enoyl-CoA hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-methylhex-2-enoyl-CoA + H2O = 3-hydroxy-2-methylhexanoyl-CoA." [UM-BBD_reactionID:r0929]
xref: EC:4.2.1.-
xref: UM-BBD_reactionID:r0929
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0034918
name: 3-hydroxy-2-methylhexanoyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxy-2-methylhexanoyl-CoA = 2-methyl-3-oxohexanoyl-CoA + 2 H+ + 2 e-." [UM-BBD_reactionID:r0930]
xref: EC:1.1.-.-
xref: UM-BBD_reactionID:r0930
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0034919
name: butyryl-CoA 2-C-propionyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-methyl-3-oxohexanoyl-CoA + CoA = propanoyl-CoA + butyryl-CoA." [UM-BBD_reactionID:r0931]
xref: EC:2.3.1.-
xref: UM-BBD_reactionID:r0931
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0034920
name: pyrene dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyrene + 2 H+ + 2 e- + O2 = cis-4,5-dihydroxy-4,5-dihydropyrene." [UM-BBD_reactionID:r0934]
xref: EC:1.13.11.-
xref: UM-BBD_reactionID:r0934
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0034921
name: cis-4,5-dihydroxy-4,5-dihydropyrene dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-4,5-dihydroxy-4,5-dihydropyrene = 4,5-dihydroxypyrene + 2 H+ + 2 e-." [UM-BBD_reactionID:r0935]
xref: EC:1.3.-.-
xref: UM-BBD_reactionID:r0935
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0034922
name: 4,5-dihydroxypyrene dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4,5-dihydroxypyrene + O2 = phenanthrene-4,5-dicarboxylate + 2 H+." [UM-BBD_reactionID:r0936]
xref: EC:1.13.11.-
xref: UM-BBD_reactionID:r0936
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0034923
name: phenanthrene-4,5-dicarboxylate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenanthrene-4,5-dicarboxylate + H+ = phenanthrene-4-carboxylate + CO2." [UM-BBD_reactionID:r0937]
xref: EC:4.1.1.-
xref: UM-BBD_reactionID:r0937
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0034924
name: cis-3,4-phenanthrenedihydrodiol-4-carboxylate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-3,4-phenanthrenedihydrodiol-4-carboxylate = 3,4-dihydroxyphenanthrene + H+ + 2 e- + CO2." [UM-BBD_reactionID:r0940]
xref: EC:1.3.-.-
xref: UM-BBD_reactionID:r0940
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0034925
name: pyrene 4,5-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyrene + O2 + 2 H+ + 2 e- = pyrene-4,5-oxide + H2O." [UM-BBD_reactionID:r0941]
xref: EC:1.14.-.-
xref: UM-BBD_reactionID:r0941
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0034926
name: pyrene-4,5-epoxide hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyrene-4,5-oxide + H2O = trans-4,5-dihydroxy-4,5-dihydropyrene." [UM-BBD_reactionID:r0942]
xref: EC:3.3.2.-
xref: UM-BBD_reactionID:r0942
is_a: GO:0016803 ! ether hydrolase activity

[Term]
id: GO:0034927
name: pyrene 1,2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyrene + O2 + 2 H+ + 2 e- = pyrene-1,2-oxide + H2O." [UM-BBD_reactionID:r0943]
xref: EC:1.14.-.-
xref: UM-BBD_reactionID:r0943
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0034928
name: 1-hydroxypyrene 6,7-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-hydroxypyrene + O2 + 2 H+ + 2 e- = 1-hydroxypyrene-6,7-oxide + H2O." [UM-BBD_reactionID:r0946]
xref: EC:1.14.-.-
xref: UM-BBD_reactionID:r0946
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0034929
name: 1-hydroxypyrene 7,8-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-hydroxypyrene + O2 + 2 H+ + 2 e- = 1-hydroxypyrene-7,8-oxide + H2O." [UM-BBD_reactionID:r0949]
xref: EC:1.14.-.-
xref: UM-BBD_reactionID:r0949
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0034930
name: 1-hydroxypyrene sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-hydroxypyrene + XSO3- = 1-pyrenylsulfate + HX." [UM-BBD_reactionID:r0952]
xref: EC:2.8.2.-
xref: UM-BBD_reactionID:r0952
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0034931
name: 1-hydroxypyrene methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-hydroxypyrene + XCH3 = 1-methoxypyrene + HX." [UM-BBD_reactionID:r0953]
xref: EC:2.1.1.-
xref: UM-BBD_reactionID:r0953
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0034932
name: 1-methoxypyrene 6,7-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-methoxypyrene + O2 + 2 H+ + 2 e- = 1-methoxypyrene-6,7-oxide + H2O." [UM-BBD_reactionID:r0954]
xref: EC:1.4.-.-
xref: UM-BBD_reactionID:r0954
is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors

[Term]
id: GO:0034933
name: 1-hydroxy-6-methoxypyrene methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-hydroxy-6-methoxypyrene + XCH3 = 1,6-dimethoxypyrene + HX." [UM-BBD_reactionID:r0956]
xref: EC:2.1.1.-
xref: UM-BBD_reactionID:r0956
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0034934
name: phenanthrene-4-carboxylate dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenanthrene-4-carboxylate + 2 H+ + 2 e- + O2 = cis-3,4-phenanthrenedihydrodiol-4-carboxylate." [UM-BBD_reactionID:r0939]
xref: EC:1.13.11.-
xref: UM-BBD_reactionID:r0939
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0034935
name: tetrachlorobenzene dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4-dichlorotoluene + NADH + H+ + O2 = 4,6-dichloro-3-methyl-cis-1,2-dihydroxycyclohexa-3,5-diene + NAD+." [UM-BBD_reactionID:r0957]
xref: EC:1.13.11.-
xref: UM-BBD_reactionID:r0957
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0034936
name: 4,6-dichloro-3-methylcatechol 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4,6-dichloro-3-methylcatechol + O2 = 3,5-dichloro-3-methyl-cis,cis-muconate + 2 H+." [UM-BBD_reactionID:r0959]
xref: EC:1.13.11.-
xref: UM-BBD_reactionID:r0959
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0034937
name: perchlorate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: perchlorate + 2 H+ + 2 e- = chlorate + H2O." [UM-BBD_reactionID:r0980]
xref: EC:1.97.1.-
xref: UM-BBD_reactionID:r0980
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0034938
name: pyrrole-2-carboxylate monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: pryrole-2-carboxylate + NADH + O2 + H+ = 5-hydroxypyrrole-2-carboxylate + NAD+ + H2O." [UM-BBD_reactionID:r0968]
xref: EC:1.14.14.-
xref: UM-BBD_reactionID:r0968
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0034939
name: 5-hydroxypyrrole-2-carboxylate tautomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-hydroxypyrrole-2-carboxylate = 5-oxo-4,5-dihydropyrrole-2-carboxylate." [UM-BBD_reactionID:r0969]
xref: EC:5.3.2.-
xref: UM-BBD_reactionID:r0969
is_a: GO:0016862 ! intramolecular oxidoreductase activity, interconverting keto- and enol-groups

[Term]
id: GO:0034940
name: 5-oxo-4,5-dihydropyrrole-2-carboxylate amidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-oxo-4,5-dihydropyrrole-2-carboxylate + 2 H2O = 2-oxoglutarate + NH3." [UM-BBD_reactionID:r0984]
xref: EC:3.5.2.-
xref: UM-BBD_reactionID:r0984
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0034941
name: pyrrole-2-carboxylate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: pryrole-2-carboxylate + H+ = pyrrole + CO2." [UM-BBD_reactionID:r0970]
xref: EC:4.1.1.-
xref: UM-BBD_reactionID:r0970
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0034942
name: cis-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-2-methyl-5-isopropylhexa-2,5-dienoic acid + ATP + CoASH = cis-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA + AMP + PPi." [UM-BBD_reactionID:r0988]
xref: EC:6.2.1.-
xref: UM-BBD_reactionID:r0988
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0034943
name: trans-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-2-methyl-5-isopropylhexa-2,5-dienoic acid + ATP + CoASH = trans-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA + AMP + PPi." [UM-BBD_reactionID:r0989]
xref: EC:6.2.1.-
xref: UM-BBD_reactionID:r0989
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0034944
name: 3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA + NAD+ = 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA + NADH+ + H+." [UM-BBD_reactionID:r0986]
xref: EC:1.1.-.-
xref: UM-BBD_reactionID:r0986
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0034945
name: 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA + CoASH = 3-isopropylbut-3-enoyl-CoA + propanoyl-CoA." [UM-BBD_reactionID:r0987]
xref: EC:2.3.1.-
xref: UM-BBD_reactionID:r0987
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0034946
name: 3-isopropylbut-3-enoyl-CoA thioesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-isopropylbut-3-enoyl-CoA + H2O = 3-isopropylbut-3-enoic acid + CoASH." [UM-BBD_reactionID:r0994]
xref: EC:3.1.2.-
xref: UM-BBD_reactionID:r0994
is_a: GO:0016790 ! thiolester hydrolase activity

[Term]
id: GO:0034947
name: terephthalate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: terephthalate + H2O = benzoate + HCO3-." [UM-BBD_reactionID:r0321]
xref: EC:4.1.1.-
xref: UM-BBD_reactionID:r0321
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0034948
name: 2,6-dihydroxypseudooxynicotine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,6-dihydroxypseudooxynicotine + H2O = 2,6-dihydroxypyridine + 4-methylaminobutyrate." [UM-BBD_reactionID:r0482]
xref: EC:3.7.1.-
xref: UM-BBD_reactionID:r0482
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0034949
name: 1,1-dichloroethane reductive dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,1-dichloroethane + 2 H+ + 2 e- = chloroethane + HCl." [UM-BBD_reactionID:r1008]
xref: EC:1.97.1.-
xref: UM-BBD_reactionID:r1008
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0034950
name: phenylboronic acid monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenylboronic acid + O2 + 2 H+ + 2 e- = phenol + B(OH)3." [UM-BBD_reactionID:r1020]
xref: EC:1.14.-.-
xref: UM-BBD_reactionID:r1020
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0034951
name: o-hydroxylaminobenzoate mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: o-hydroxylaminobenzoate = 3-hydroxyanthranilate." [UM-BBD_reactionID:r1026]
xref: EC:5.4.99.-
xref: MetaCyc:RXN-8846
xref: UM-BBD_reactionID:r1026
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0034952
name: malonate semialdehyde decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: malonate semialdehyde + H+ = acetaldehyde + CO2." [UM-BBD_reactionID:r0266]
xref: EC:4.1.1.-
xref: UM-BBD_reactionID:r0266
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0034953
name: perillyl-CoA hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: perillyl-CoA + H2O = 2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA." [UM-BBD_reactionID:r1002]
xref: EC:4.2.1.-
xref: UM-BBD_reactionID:r1002
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0034954
name: diphenyl ether 2,3-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: diphenyl ether + O2 = 2,3-dihydroxydiphenyl ether." [UM-BBD_reactionID:r1450]
xref: EC:1.14.12.-
xref: UM-BBD_reactionID:r1450
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0034955
name: 2,3-dihydroxydiphenyl ether dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-dihydroxydiphenyl ether + O2 + H2O = 2-hydroxymuconate + phenol." [UM-BBD_reactionID:r1451]
xref: EC:1.13.11.-
xref: UM-BBD_reactionID:r1451
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0034956
name: diphenyl ether 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: diphenyl ether + NADH + O2 + H+ = phenol + catechol + NAD+." [UM-BBD_reactionID:r1453]
xref: EC:1.13.11.-
xref: UM-BBD_reactionID:r1453
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0034957
name: 3-nitrophenol nitroreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-nitrophenol + 2 NADH + 2 H+ = 3-hydroxyaminophenol + 2 NAD+ + H2O." [UM-BBD_reactionID:r1495]
xref: EC:1.7.1.-
xref: UM-BBD_reactionID:r1495
is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor

[Term]
id: GO:0034958
name: aminohydroquinone monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: aminohydroquinone + 2 e- + 2 H+ + 1/2 O2 = 1,2,4-benzenetriol + NH3." [UM-BBD_reactionID:r1497]
xref: EC:3.5.99.-
xref: UM-BBD_reactionID:r1497
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

[Term]
id: GO:0034959
name: endothelin maturation
namespace: biological_process
def: "The process leading to the attainment of the full functional capacity of endothelin by conversion of Big-endothelin substrate into mature endothelin." [GOC:BHF, GOC:rl]
is_a: GO:0016486 ! peptide hormone processing
relationship: part_of GO:0002002 ! regulation of angiotensin levels in blood

[Term]
id: GO:0034963
name: box C/D snoRNA processing
namespace: biological_process
def: "Any process involved in the conversion of a primary box C/D type small nucleolar RNA (snoRNA) transcript into a mature box C/D snoRNA." [GOC:mah]
is_a: GO:0033967 ! box C/D snoRNA metabolic process
is_a: GO:0043144 ! snoRNA processing

[Term]
id: GO:0034964
name: box H/ACA snoRNA processing
namespace: biological_process
def: "Any process involved in the conversion of a primary box H/ACA type small nucleolar RNA (snoRNA) transcript into a mature box H/ACA snoRNA." [GOC:mah]
is_a: GO:0033979 ! box H/ACA snoRNA metabolic process
is_a: GO:0043144 ! snoRNA processing

[Term]
id: GO:0034965
name: intronic box C/D snoRNA processing
namespace: biological_process
def: "Any process involved in the conversion of a primary box C/D type small nucleolar RNA (snoRNA) transcript that resides within, and is processed from, the intron of a pre-mRNA into a mature box C/D snoRNA." [GOC:mah]
is_a: GO:0031070 ! intronic snoRNA processing
is_a: GO:0034963 ! box C/D snoRNA processing

[Term]
id: GO:0034966
name: intronic box H/ACA snoRNA processing
namespace: biological_process
def: "Any process involved in the conversion of a primary box H/ACA type small nucleolar RNA (snoRNA) transcript that resides within, and is processed from, the intron of a pre-mRNA into a mature box H/ACA snoRNA." [GOC:mah]
is_a: GO:0031070 ! intronic snoRNA processing
is_a: GO:0034964 ! box H/ACA snoRNA processing

[Term]
id: GO:0034967
name: Set3 complex
namespace: cellular_component
def: "A histone deacetylase complex that is involved in transcriptional regulation. In S. cerevisiae, this complex consists of Set3p, Snt1p, Hos4p, Sif2p, Cpr1p, Hos2p, and Hst1p." [GOC:ds, PMID:11711434]
synonym: "HDAC3 complex" EXACT []
synonym: "SET3C" EXACT []
is_a: GO:0000118 ! histone deacetylase complex
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000790 ! nuclear chromatin

[Term]
id: GO:0034968
name: histone lysine methylation
namespace: biological_process
def: "The modification of a histone by addition of one or more methyl groups to a lysine residue." [GOC:mah, GOC:pr]
is_a: GO:0016571 ! histone methylation
is_a: GO:0018022 ! peptidyl-lysine methylation

[Term]
id: GO:0034969
name: histone arginine methylation
namespace: biological_process
def: "The modification of a histone by addition of a methyl group to an arginine residue." [GOC:mah]
is_a: GO:0016571 ! histone methylation
is_a: GO:0018216 ! peptidyl-arginine methylation

[Term]
id: GO:0034970
name: histone H3-R2 methylation
namespace: biological_process
def: "The modification of histone H3 by addition of a methyl group to arginine at position 2 of the histone." [GOC:mah]
synonym: "histone H3 R2 methylation" EXACT []
synonym: "histone H3R2me" EXACT []
synonym: "histone lysine H3 R2 methylation" EXACT []
is_a: GO:0034969 ! histone arginine methylation

[Term]
id: GO:0034971
name: histone H3-R17 methylation
namespace: biological_process
def: "The modification of histone H3 by addition of a methyl group to arginine at position 17 of the histone." [GOC:mah]
synonym: "histone H3 R17 methylation" EXACT []
synonym: "histone H3R17me" EXACT []
synonym: "histone lysine H3 R17 methylation" EXACT []
is_a: GO:0034969 ! histone arginine methylation

[Term]
id: GO:0034972
name: histone H3-R26 methylation
namespace: biological_process
def: "The modification of histone H3 by addition of a methyl group to arginine at position 26 of the histone." [GOC:mah]
synonym: "histone H3 R26 methylation" EXACT []
synonym: "histone H3R26me" EXACT []
synonym: "histone lysine H3 R26 methylation" EXACT []
is_a: GO:0034969 ! histone arginine methylation

[Term]
id: GO:0034973
name: Sid2-Mob1 complex
namespace: cellular_component
def: "A protein complex that contains a protein kinase (Sid2 in S. pombe) and its regulatory subunit (Mob1). The Sid2p-Mob1p kinase complex is a component of the septation initiation network in fission yeast (called the mitotic exit network in S. cerevisiae) and is required for cytokinesis. The analogous complex in S. cerevisiae is called Dbf2p-Mob1p complex." [GOC:vw, PMID:10837231, PMID:15060149]
synonym: "Dbf2p-Mob1p complex" EXACT []
synonym: "Sid2-Mob1 kinase complex" EXACT []
synonym: "Sid2p-Mob1p complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0034974
name: Swi5-Swi2 complex
namespace: cellular_component
def: "A protein complex involved that contains proteins known in Schizosaccharomyces as Swi5 monomers and Swi2, and is involved in mating type switching." [PMID:14663140]
comment: Note that this term refers to Schizosaccharomyces pombe Swi5 and Swi2, which should not be confused with the unrelated Saccharomyces Swi5p and Swi2p.
synonym: "Swi5 complex" BROAD []
is_a: GO:0043234 ! protein complex
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000790 ! nuclear chromatin

[Term]
id: GO:0034975
name: protein folding in endoplasmic reticulum
namespace: biological_process
def: "A protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation)." [GOC:mah, GOC:vw]
synonym: "oxidative protein folding" EXACT [PMID:25091901]
synonym: "protein folding in ER" EXACT []
is_a: GO:0006457 ! protein folding

[Term]
id: GO:0034976
name: response to endoplasmic reticulum stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:cjm, GOC:mah]
synonym: "cellular response to endoplasmic reticulum stress" EXACT []
synonym: "ER stress response" EXACT []
synonym: "response to ER stress" EXACT []
is_a: GO:0033554 ! cellular response to stress

[Term]
id: GO:0034977
name: ABIN2-NFKB1-MAP3K8 complex
namespace: cellular_component
def: "A protein complex that contains the precursor form of NF-kappaB (p105), the NF-kappaB inhibitor ABIN-2, and the kinase TPL-2 (MAP3K8); the complex stabilizes TPL-2 and is involved in signaling in lipopolysaccharide (LPS)-stimulated macrophages." [PMID:15169888]
synonym: "ABIN2-NFKB1-TPL-1 complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0034978
name: PDX1-PBX1b-MRG1 complex
namespace: cellular_component
def: "A protein complex that contains the homeodomain proteins PDX1, PBX1b and MRG1 (MEIS2) and is involved in the transcriptional regulation of pancreatic acinar cell-specific genes." [PMID:11279116, PMID:9710595]
synonym: "acinar cell-specific C complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0034979
name: NAD-dependent protein deacetylase activity
namespace: molecular_function
def: "Catalysis of the removal of one or more acetyl groups from a protein, requiring NAD." [GOC:BHF, GOC:mah]
is_a: GO:0033558 ! protein deacetylase activity

[Term]
id: GO:0034980
name: FHL2-CREB complex
namespace: cellular_component
def: "A protein complex that contains CREB and FHL2, and is involved in transcriptional regulation." [PMID:11046156]
is_a: GO:0033202 ! DNA helicase complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0034981
name: FHL3-CREB complex
namespace: cellular_component
def: "A protein complex that contains CREB and FHL3, and is involved in transcriptional regulation." [PMID:11046156]
is_a: GO:0033202 ! DNA helicase complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0034982
name: mitochondrial protein processing
namespace: biological_process
def: "The peptide cleavage of mitochondrial proteins, including cleavage contributing to their import." [GOC:curators]
synonym: "mitochondrial protein modification" RELATED []
is_a: GO:0016485 ! protein processing
is_a: GO:0044267 ! cellular protein metabolic process
intersection_of: GO:0016485 ! protein processing
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion

[Term]
id: GO:0034983
name: peptidyl-lysine deacetylation
namespace: biological_process
def: "The removal of an acetyl group from an acetylated lysine residue in a peptide or protein." [GOC:BHF, GOC:mah]
synonym: "protein lysine acetylation" RELATED []
is_a: GO:0006476 ! protein deacetylation
is_a: GO:0018205 ! peptidyl-lysine modification

[Term]
id: GO:0034985
name: Ecsit-NDUFAF1 complex
namespace: cellular_component
def: "Any large protein complex that contains Ecsit and NDUFAF1, is located in the mitochondrion, and is involved in the assembly of complex I of the oxidative phosphorylation system. In mammalian cells, three complexes of approximately 500, 600, and 850 kDa containing the 45 kDa isoform of Ecsit and NDUFAF1 have been observed." [PMID:17344420]
is_a: GO:0098798 ! mitochondrial protein complex
relationship: part_of GO:0005759 ! mitochondrial matrix

[Term]
id: GO:0034986
name: iron chaperone activity
namespace: molecular_function
def: "Assists in the delivery of iron ions to target proteins or compartments." [GOC:BHF, GOC:vk]
is_a: GO:0005506 ! iron ion binding
is_a: GO:0016530 ! metallochaperone activity

[Term]
id: GO:0034987
name: immunoglobulin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with one or more specific sites on an immunoglobulin receptor molecule." [GOC:BHF, GOC:vk]
synonym: "Fc receptor binding" RELATED []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0034988
name: Fc-gamma receptor I complex binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with one or more specific sites on the Fc-gamma receptor I complex. The complex functions primarily as an activating receptor for IgG." [GOC:BHF, GOC:vk]
is_a: GO:0032403 ! protein complex binding
is_a: GO:0034987 ! immunoglobulin receptor binding

[Term]
id: GO:0034990
name: nuclear mitotic cohesin complex
namespace: cellular_component
def: "A cohesin complex that mediates sister chromatid cohesion in the nucleus during mitosis; has a subunit composition distinct from that of the meiotic cohesin complex." [GOC:mah]
comment: Note that this term should be used to annotate gene products found in cohesin complexes in organisms that undergo closed mitosis (i. e. where the nuclear envelope does not break down, as in fungi). For organisms in which the nuclear envelope breaks down during mitosis, the parent should be used.
is_a: GO:0000798 ! nuclear cohesin complex
is_a: GO:0030892 ! mitotic cohesin complex

[Term]
id: GO:0034991
name: nuclear meiotic cohesin complex
namespace: cellular_component
def: "A cohesin complex that mediates sister chromatid cohesion in the nucleus during meiosis; has a subunit composition distinct from that of the meiotic cohesin complex." [GOC:mah]
comment: Note that this term should be used to annotate gene products found in cohesin complexes in organisms that undergo closed mitosis (i. e. where the nuclear envelope does not break down, as in fungi). For organisms in which the nuclear envelope breaks down during mitosis, the parent should be used.
is_a: GO:0000798 ! nuclear cohesin complex
is_a: GO:0030893 ! meiotic cohesin complex

[Term]
id: GO:0034992
name: microtubule organizing center attachment site
namespace: cellular_component
def: "A region of the nuclear envelope to which a microtubule organizing center (MTOC) attaches; protein complexes embedded in the nuclear envelope mediate direct or indirect linkages between the microtubule cytoskeleton and the nuclear envelope." [GOC:mah, PMID:18692466]
comment: Note that this term should not be confused with the cellular component term 'perinuclear region ; GO:0048471'.
synonym: "MAS" EXACT []
synonym: "microtubule organising centre attachment site" EXACT []
synonym: "MTOC attachment site" EXACT []
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0005635 ! nuclear envelope

[Term]
id: GO:0034993
name: LINC complex
namespace: cellular_component
def: "A protein complex that spans the nuclear outer and inner membranes, thereby linking the major cytoplasmic cytoskeleton elements to the nuclear lumen; the complex is conserved in eukaryotes and contains proteins with SUN and KASH domains." [GOC:mah, PMID:18692466]
synonym: "LInker of Nucleoskeleton and Cytoskeleton complex" EXACT []
synonym: "SUN-KASH complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0005635 ! nuclear envelope
relationship: part_of GO:0034992 ! microtubule organizing center attachment site

[Term]
id: GO:0034994
name: microtubule organizing center attachment site organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center attachment site. A microtubule organizing center attachment site is a region of the nuclear envelope to which a microtubule organizing center (MTOC) attaches." [GOC:mah, PMID:18692466]
synonym: "MAS organization" EXACT []
synonym: "microtubule organising centre attachment site organisation" RELATED []
synonym: "MTOC attachment site organization" EXACT []
is_a: GO:0016043 ! cellular component organization
is_a: GO:0044763 ! single-organism cellular process
relationship: part_of GO:0006998 ! nuclear envelope organization

[Term]
id: GO:0034995
name: SC5b-7 complex
namespace: cellular_component
def: "A protein complex that consist of complement components C5b6 and C7 stably inserted in a cell membrane. Formation of the SC5b-7 complex is the first phase of membrane attack complex assembly." [PMID:10090939]
is_a: GO:0098797 ! plasma membrane protein complex
relationship: part_of GO:0005887 ! integral component of plasma membrane

[Term]
id: GO:0034996
name: RasGAP-Fyn-Lyn-Yes complex
namespace: cellular_component
def: "A protein complex that consists of a GTPase activator protein (GAP) for Ras and three Src family protein tyrosine kinases, Fyn, Lyn and Yes. The complex is involved in signaling upon platelet activation." [PMID:1544885]
comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
synonym: "p21(ras)GAP-Fyn-Lyn-Yes complex, thrombin stimulated" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0034997
name: alphav-beta5 integrin-vitronectin complex
namespace: cellular_component
def: "A protein complex that comprises one integrin alphav subunit, one integrin beta5 subunit, and vitronectin." [PMID:1694173, Reactome:REACT_14045.1]
synonym: "ITGAV-ITGB5-VTN complex" NARROW [CORUM:3117]
is_a: GO:0098797 ! plasma membrane protein complex
relationship: part_of GO:0005887 ! integral component of plasma membrane

[Term]
id: GO:0034998
name: oligosaccharyltransferase I complex
namespace: cellular_component
def: "An oligosaccharyltransferase (OST) complex that contains at least seven polypeptides and is the major OST complex in mammalian cells. Of the three forms of mammalian OST complex identified, the OSTI complex has the weakest affinity for ribosomes." [PMID:15835887]
synonym: "OSTCI" EXACT []
is_a: GO:0008250 ! oligosaccharyltransferase complex

[Term]
id: GO:0034999
name: oligosaccharyltransferase II complex
namespace: cellular_component
def: "An oligosaccharyltransferase (OST) complex that contains the seven polypeptides found in OST complex I, plus heterotrimeric Sec61alpha-beta-gamma. Of the three forms of mammalian OST complexes identified, the OSTII complex has intermediate affinity for ribosomes." [GOC:BHF, PMID:15835887]
synonym: "OSTCII" EXACT []
is_a: GO:0008250 ! oligosaccharyltransferase complex

[Term]
id: GO:0035000
name: oligosaccharyltransferase III complex
namespace: cellular_component
def: "An oligosaccharyltransferase (OST) complex that contains the seven polypeptides found in OST complex I, plus heterotrimeric Sec61alpha-beta-gamma and the tetrameric TRAP complex. Of the three forms of mammalian OST complexes identified, the OSTIII complex has the strongest affinity for ribosomes." [PMID:15835887]
synonym: "OSTCIII" EXACT []
is_a: GO:0008250 ! oligosaccharyltransferase complex

[Term]
id: GO:0035001
name: dorsal trunk growth, open tracheal system
namespace: biological_process
def: "Growth of epithelial tubes that originate from pits in an open tracheal system and grow towards each other to meet and form a continuous open tube called the dorsal trunk. The dorsal trunk extends from the anterior spiracle to the posterior spiracle of the larva and forms the main airway of the insect tracheal system." [GOC:mtg_sensu, ISBN:0879694238]
synonym: "dorsal trunk growth" RELATED []
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0007424 ! open tracheal system development

[Term]
id: GO:0035002
name: liquid clearance, open tracheal system
namespace: biological_process
def: "The clearance of liquid from the epithelial tubes of an open tracheal system, shortly before the emergence of the larva, to generate an air-filled tubule system." [GOC:mtg_sensu, PMID:12571352]
synonym: "tracheal liquid clearance" EXACT []
is_a: GO:0042045 ! epithelial fluid transport
relationship: part_of GO:0007424 ! open tracheal system development

[Term]
id: GO:0035003
name: subapical complex
namespace: cellular_component
def: "The most apical region of the lateral plasma membrane of an invertebrate epithelial cell. The subapical complex lies above the zonula adherens and the septate junction, and is comparable to the position of the tight junction of vertebrate cells." [PMID:11752566, PMID:12500938]
synonym: "SAC" BROAD []
is_a: GO:0032991 ! macromolecular complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0043296 ! apical junction complex

[Term]
id: GO:0035004
name: phosphatidylinositol 3-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol 3-phosphate. This reaction is the addition of a phosphate group to phosphatidylinositol or one of its phosphorylated derivatives at the 3' position of the inositol ring." [GOC:bf, PMID:10209156, PMID:9255069]
synonym: "phosphoinositide 3-kinase activity" EXACT [GOC:curators]
xref: EC:2.7.1.-
xref: Reactome:REACT_111081 "Synthesis of PIP3 from PIP2 by PI3K, Homo sapiens"
xref: Wikipedia:Phosphoinositide_3-kinase
is_a: GO:0016301 ! kinase activity
relationship: part_of GO:0046854 ! phosphatidylinositol phosphorylation

[Term]
id: GO:0035005
name: 1-phosphatidylinositol-4-phosphate 3-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.154, RHEA:18376]
synonym: "ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 3-phosphotransferase activity" EXACT [EC:2.7.1.154]
synonym: "C2-domain-containing phosphoinositide 3-kinase activity" NARROW [EC:2.7.1.154]
synonym: "phosphatidylinositol 3-kinase activity, class I" NARROW []
synonym: "phosphatidylinositol 3-kinase activity, class II" NARROW []
synonym: "phosphatidylinositol 3-kinase, class I, catalyst activity" NARROW []
synonym: "phosphatidylinositol-4-phosphate 3-kinase activity" EXACT []
synonym: "type II phosphoinositide 3-kinase activity" RELATED [EC:2.7.1.154]
xref: EC:2.7.1.154
xref: KEGG:R05795
xref: MetaCyc:2.7.1.154-RXN
xref: RHEA:18376
is_a: GO:0016307 ! phosphatidylinositol phosphate kinase activity
is_a: GO:0035004 ! phosphatidylinositol 3-kinase activity

[Term]
id: GO:0035006
name: melanization defense response
namespace: biological_process
def: "The blackening of the wounded area of the cuticle or the surface of invading pathogens, parasites or parasitoids, resulting from a proteolytic cascade leading to the de novo synthesis and deposition of melanin." [GOC:bf, PMID:12408809]
synonym: "melanization defence response" EXACT []
is_a: GO:0006582 ! melanin metabolic process
is_a: GO:0045087 ! innate immune response

[Term]
id: GO:0035007
name: regulation of melanization defense response
namespace: biological_process
def: "Any process that affects the rate, extent or location of the melanization defense response during injury or invasion." [GOC:bf]
synonym: "regulation of melanization defence response" EXACT []
is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:0043455 ! regulation of secondary metabolic process
is_a: GO:0045088 ! regulation of innate immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035006 ! melanization defense response
relationship: regulates GO:0035006 ! melanization defense response

[Term]
id: GO:0035008
name: positive regulation of melanization defense response
namespace: biological_process
def: "Any process that increases the rate or extent of the melanization defense response during injury or invasion." [GOC:bf]
synonym: "activation of melanization defense response" NARROW []
synonym: "positive regulation of melanization defence response" EXACT []
synonym: "stimulation of melanization defense response" NARROW []
synonym: "up regulation of melanization defense response" EXACT []
synonym: "up-regulation of melanization defense response" EXACT []
synonym: "upregulation of melanization defense response" EXACT []
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0035007 ! regulation of melanization defense response
is_a: GO:0045089 ! positive regulation of innate immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035006 ! melanization defense response
relationship: positively_regulates GO:0035006 ! melanization defense response

[Term]
id: GO:0035009
name: negative regulation of melanization defense response
namespace: biological_process
def: "Any process that reduces the rate or extent of the melanization defense response. This regulation is critical to limit melanization to the site of injury or infection." [GOC:bf, PMID:12408809]
synonym: "down regulation of melanization defense response" EXACT []
synonym: "down-regulation of melanization defense response" EXACT []
synonym: "downregulation of melanization defense response" EXACT []
synonym: "inhibition of melanization defense response" NARROW []
synonym: "negative regulation of melanization defence response" EXACT []
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0035007 ! regulation of melanization defense response
is_a: GO:0045824 ! negative regulation of innate immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035006 ! melanization defense response
relationship: negatively_regulates GO:0035006 ! melanization defense response

[Term]
id: GO:0035010
name: encapsulation of foreign target
namespace: biological_process
def: "Events resulting in the formation of a multilayered cellular sheath surrounding an invader and thus preventing its development. This defense mechanism is often seen in insects in response to nematodes or parasitoids, which are too large to be phagocytosed by individual hemocytes. In some organisms the capsule is blackened due to melanization." [GO_REF:0000022, GOC:bf, GOC:mtg_15nov05, PMID:11846478, PMID:12225920]
comment: This term was improved by GO_REF:0000022. It was moved.
is_a: GO:0002252 ! immune effector process

[Term]
id: GO:0035011
name: melanotic encapsulation of foreign target
namespace: biological_process
def: "Formation of a multilayered, melanized sheath of cells around a foreign invader." [GOC:bf]
is_a: GO:0035006 ! melanization defense response
is_a: GO:0035010 ! encapsulation of foreign target

[Term]
id: GO:0035012
name: polytene chromosome, telomeric region
namespace: cellular_component
def: "The terminal region of a polytene chromosome." [GOC:bf]
is_a: GO:0000781 ! chromosome, telomeric region
intersection_of: GO:0000781 ! chromosome, telomeric region
intersection_of: part_of GO:0005700 ! polytene chromosome
relationship: part_of GO:0005700 ! polytene chromosome

[Term]
id: GO:0035013
name: myosuppressin receptor activity
namespace: molecular_function
def: "Combining with the peptide myosuppressin to initiate a change in cell activity." [GOC:bf]
is_a: GO:0008528 ! G-protein coupled peptide receptor activity

[Term]
id: GO:0035014
name: phosphatidylinositol 3-kinase regulator activity
namespace: molecular_function
def: "Modulates the activity of any of the phosphatidylinositol 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates." [GOC:bf, PMID:9255069]
comment: See also the molecular function term 'phosphoinositide 3-kinase activity ; GO:0035004'.
synonym: "phosphoinositide 3-kinase regulator activity" EXACT [GOC:curators]
synonym: "PI3K regulator activity" EXACT []
is_a: GO:0019207 ! kinase regulator activity
relationship: has_part GO:0036313 ! phosphatidylinositol 3-kinase catalytic subunit binding
relationship: part_of GO:0043551 ! regulation of phosphatidylinositol 3-kinase activity
relationship: regulates GO:0035004 ! phosphatidylinositol 3-kinase activity

[Term]
id: GO:0035015
name: elongation of arista core
namespace: biological_process
def: "The increase in length of the aristal core. The arista is the terminal segment of the antenna and consists of a central core and a series of lateral extensions." [GOC:bf, PMID:11404081]
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0048800 ! antennal morphogenesis

[Term]
id: GO:0035016
name: elongation of arista lateral
namespace: biological_process
def: "The increase in length of the aristal laterals. The arista is the terminal segment of the antenna and consists of a central core and a series of lateral extensions." [GOC:bf, PMID:11404081]
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0048800 ! antennal morphogenesis

[Term]
id: GO:0035017
name: cuticle pattern formation
namespace: biological_process
def: "The regionalization process that gives rise to the patterns of cell differentiation in the cuticle." [GOC:bf]
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0042335 ! cuticle development

[Term]
id: GO:0035018
name: adult chitin-based cuticle pattern formation
namespace: biological_process
def: "The process that gives rise to the patterns of cell differentiation that will arise in the chitin-based adult cuticle. An example of this process is adult chitin-based cuticle pattern formation in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
synonym: "adult cuticle pattern formation" BROAD []
is_a: GO:0035017 ! cuticle pattern formation
relationship: part_of GO:0008365 ! adult chitin-based cuticle development

[Term]
id: GO:0035019
name: somatic stem cell population maintenance
namespace: biological_process
def: "Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line." [GOC:bf, ISBN:0582227089]
is_a: GO:0019827 ! stem cell population maintenance

[Term]
id: GO:0035020
name: regulation of Rac protein signal transduction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Rac protein signal transduction." [GOC:bf]
is_a: GO:0046578 ! regulation of Ras protein signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016601 ! Rac protein signal transduction
relationship: regulates GO:0016601 ! Rac protein signal transduction

[Term]
id: GO:0035021
name: negative regulation of Rac protein signal transduction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Rac protein signal transduction." [GOC:bf]
synonym: "down regulation of Rac protein signal transduction" EXACT []
synonym: "down-regulation of Rac protein signal transduction" EXACT []
synonym: "downregulation of Rac protein signal transduction" EXACT []
synonym: "inhibition of Rac protein signal transduction" NARROW []
is_a: GO:0035020 ! regulation of Rac protein signal transduction
is_a: GO:0046580 ! negative regulation of Ras protein signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016601 ! Rac protein signal transduction
relationship: negatively_regulates GO:0016601 ! Rac protein signal transduction

[Term]
id: GO:0035022
name: positive regulation of Rac protein signal transduction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of Rac protein signal transduction." [GOC:bf]
synonym: "activation of Rac protein signal transduction" NARROW []
synonym: "stimulation of Rac protein signal transduction" NARROW []
synonym: "up regulation of Rac protein signal transduction" EXACT []
synonym: "up-regulation of Rac protein signal transduction" EXACT []
synonym: "upregulation of Rac protein signal transduction" EXACT []
is_a: GO:0035020 ! regulation of Rac protein signal transduction
is_a: GO:0046579 ! positive regulation of Ras protein signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016601 ! Rac protein signal transduction
relationship: positively_regulates GO:0016601 ! Rac protein signal transduction

[Term]
id: GO:0035023
name: regulation of Rho protein signal transduction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]
is_a: GO:0046578 ! regulation of Ras protein signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007266 ! Rho protein signal transduction
relationship: regulates GO:0007266 ! Rho protein signal transduction

[Term]
id: GO:0035024
name: negative regulation of Rho protein signal transduction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]
synonym: "down regulation of Rho protein signal transduction" EXACT []
synonym: "down-regulation of Rho protein signal transduction" EXACT []
synonym: "downregulation of Rho protein signal transduction" EXACT []
synonym: "inhibition of Rho protein signal transduction" NARROW []
is_a: GO:0035023 ! regulation of Rho protein signal transduction
is_a: GO:0046580 ! negative regulation of Ras protein signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007266 ! Rho protein signal transduction
relationship: negatively_regulates GO:0007266 ! Rho protein signal transduction

[Term]
id: GO:0035025
name: positive regulation of Rho protein signal transduction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]
synonym: "activation of Rho protein signal transduction" NARROW []
synonym: "stimulation of Rho protein signal transduction" NARROW []
synonym: "up regulation of Rho protein signal transduction" EXACT []
synonym: "up-regulation of Rho protein signal transduction" EXACT []
synonym: "upregulation of Rho protein signal transduction" EXACT []
is_a: GO:0035023 ! regulation of Rho protein signal transduction
is_a: GO:0046579 ! positive regulation of Ras protein signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007266 ! Rho protein signal transduction
relationship: positively_regulates GO:0007266 ! Rho protein signal transduction

[Term]
id: GO:0035026
name: leading edge cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of leading edge cells, cells at the front of a migrating epithelial sheet." [GOC:bf]
is_a: GO:0030855 ! epithelial cell differentiation

[Term]
id: GO:0035027
name: leading edge cell fate commitment
namespace: biological_process
def: "The commitment of cells to leading edge cell fate and their capacity to differentiate into leading edge cells. Leading edge cells are found at the front of a migrating epithelial sheet." [GOC:bf]
is_a: GO:0072148 ! epithelial cell fate commitment
relationship: part_of GO:0035026 ! leading edge cell differentiation

[Term]
id: GO:0035028
name: leading edge cell fate determination
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a leading edge cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:bf]
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0035027 ! leading edge cell fate commitment

[Term]
id: GO:0035029
name: dorsal closure, leading edge cell fate commitment
namespace: biological_process
def: "The commitment of cells to leading edge cell fate during dorsal closure. Leading edge cells are the dorsal-most cells of the migrating epidermis." [GOC:bf]
is_a: GO:0035027 ! leading edge cell fate commitment
intersection_of: GO:0035027 ! leading edge cell fate commitment
intersection_of: part_of GO:0007391 ! dorsal closure
relationship: part_of GO:0007391 ! dorsal closure
relationship: part_of GO:0046663 ! dorsal closure, leading edge cell differentiation

[Term]
id: GO:0035032
name: phosphatidylinositol 3-kinase complex, class III
namespace: cellular_component
def: "A phosphatidylinositol 3-kinase complex that contains a catalytic class III phosphoinositide 3-kinase (PI3K) subunit bound to a regulatory (adaptor) subunit. Additional adaptor proteins may be present. Class III PI3Ks have a substrate specificity restricted to phosphatidylinositol (PI)." [GOC:bf, PMID:9255069]
synonym: "class III PI3K complex" EXACT []
synonym: "phosphoinositide 3-kinase complex, class III" EXACT [GOC:curators]
is_a: GO:0005942 ! phosphatidylinositol 3-kinase complex

[Term]
id: GO:0035033
name: histone deacetylase regulator activity
namespace: molecular_function
def: "Modulates the activity of histone deacetylase." [GOC:bf]
comment: See also the molecular function term 'histone deacetylase activity ; GO:0004407'.
is_a: GO:0030234 ! enzyme regulator activity
relationship: has_part GO:0042826 ! histone deacetylase binding
relationship: part_of GO:0031063 ! regulation of histone deacetylation
relationship: regulates GO:0004407 ! histone deacetylase activity

[Term]
id: GO:0035034
name: histone acetyltransferase regulator activity
namespace: molecular_function
def: "Modulates the activity of histone acetyltransferase." [GOC:bf]
comment: See also the molecular function term 'histone acetyltransferase activity ; GO:0004402'.
synonym: "histone acetylase regulator activity" EXACT []
is_a: GO:0030234 ! enzyme regulator activity
relationship: has_part GO:0035035 ! histone acetyltransferase binding
relationship: part_of GO:0035065 ! regulation of histone acetylation
relationship: regulates GO:0004402 ! histone acetyltransferase activity

[Term]
id: GO:0035035
name: histone acetyltransferase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the enzyme histone acetyltransferase." [GOC:bf]
synonym: "histone acetylase binding" EXACT []
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0035036
name: sperm-egg recognition
namespace: biological_process
def: "The initial contact step made between the sperm plasma membrane and outer layer of the egg during fertilization." [GOC:bf]
is_a: GO:0009988 ! cell-cell recognition
is_a: GO:0044702 ! single organism reproductive process
relationship: part_of GO:0007338 ! single fertilization

[Term]
id: GO:0035037
name: sperm entry
namespace: biological_process
def: "An endocytosis process that results in penetration of the egg shell through the micropyle (a specialized anterior opening in the vitelline envelope) and entry of the entire sperm, including the surrounding plasma membrane and the sperm tail, into the egg cytoplasm. This step in fertilization is seen in Drosophila, where a plasma membrane fusion event between the sperm and the egg does not occur." [GOC:bf, PMID:9630751]
is_a: GO:0006897 ! endocytosis
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0044765 ! single-organism transport
relationship: part_of GO:0007338 ! single fertilization

[Term]
id: GO:0035038
name: female pronucleus assembly
namespace: biological_process
def: "Assembly of the haploid nucleus of the unfertilized egg." [GOC:bf, ISBN:0582227089]
synonym: "female pronucleus assembly" RELATED [GOC:dph]
is_a: GO:0006997 ! nucleus organization
is_a: GO:0022414 ! reproductive process
is_a: GO:0070925 ! organelle assembly
relationship: part_of GO:0007338 ! single fertilization

[Term]
id: GO:0035039
name: male pronucleus assembly
namespace: biological_process
def: "The conversion at fertilization of the inactive sperm nucleus into a male pronucleus with its chromosomes processed for the first zygotic division." [GOC:bf, PMID:11735001]
synonym: "male pronucleus formation" RELATED [GOC:dph]
is_a: GO:0006997 ! nucleus organization
is_a: GO:0022414 ! reproductive process
is_a: GO:0070925 ! organelle assembly
relationship: part_of GO:0007338 ! single fertilization

[Term]
id: GO:0035040
name: sperm nuclear envelope removal
namespace: biological_process
def: "Removal of the sperm nuclear envelope, allowing entry of maternal factors into the sperm nucleus." [GOC:bf, PMID:11735001]
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0051081 ! nuclear envelope disassembly
relationship: part_of GO:0035039 ! male pronucleus assembly

[Term]
id: GO:0035041
name: sperm chromatin decondensation
namespace: biological_process
def: "Unwinding of the condensed nuclear chromatin of an inactive sperm nucleus." [GOC:bf, PMID:11735001]
is_a: GO:0006325 ! chromatin organization
is_a: GO:0022414 ! reproductive process
relationship: part_of GO:0035039 ! male pronucleus assembly

[Term]
id: GO:0035042
name: fertilization, exchange of chromosomal proteins
namespace: biological_process
def: "Replacement of sperm-specific chromosomal proteins with somatic histones, to allow the paternal genome to acquire a nucleosomal chromatin organization compatible with nuclear activity." [GOC:bf, PMID:11735001]
synonym: "sperm-specific histone exchange" EXACT []
synonym: "sperm-specific histone replacement" EXACT []
is_a: GO:0022414 ! reproductive process
is_a: GO:0043486 ! histone exchange
relationship: part_of GO:0035041 ! sperm chromatin decondensation

[Term]
id: GO:0035043
name: male pronuclear envelope synthesis
namespace: biological_process
def: "Assembly of a nuclear envelope containing nuclear pores and a lamina around the male pronucleus, the final step in sperm pronuclear formation." [GOC:bf, PMID:11735001]
is_a: GO:0018985 ! pronuclear envelope synthesis
relationship: part_of GO:0035039 ! male pronucleus assembly

[Term]
id: GO:0035044
name: sperm aster formation
namespace: biological_process
def: "Formation and organization of an aster composed of microtubule arrays originating from the sperm basal body and extending virtually to the egg periphery. The sperm aster ensures the appropriate positioning of the male and female pronuclei." [GOC:bf, ISBN:0879694238]
is_a: GO:0000226 ! microtubule cytoskeleton organization
is_a: GO:0044702 ! single organism reproductive process
relationship: part_of GO:0007338 ! single fertilization

[Term]
id: GO:0035045
name: sperm plasma membrane disassembly
namespace: biological_process
def: "The gradual disintegration of the sperm plasma membrane following insemination. This process is seen in Drosophila after entry of the entire sperm, surrounded by its plasma membrane, into the egg." [GOC:bf, ISBN:0879694238]
synonym: "sperm plasma membrane breakdown" EXACT []
synonym: "sperm plasma membrane catabolism" EXACT []
synonym: "sperm plasma membrane degradation" EXACT []
is_a: GO:0007009 ! plasma membrane organization
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0030397 ! membrane disassembly
relationship: part_of GO:0007338 ! single fertilization

[Term]
id: GO:0035046
name: pronuclear migration
namespace: biological_process
def: "The directed movement of the male and female pronuclei towards each other prior to their fusion." [GOC:bf, PMID:9199363]
is_a: GO:0007097 ! nuclear migration
is_a: GO:0022414 ! reproductive process
relationship: part_of GO:0007338 ! single fertilization

[Term]
id: GO:0035047
name: centrosomal and pronuclear rotation
namespace: biological_process
def: "The rotation of centrosomes and associated pronuclei in one-cell embryos such as those of Caenorhabditis elegans, occurring as a transition between pronuclear migration and pronuclear fusion." [GOC:bf, ISBN:087969307X, PMID:10085292]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0048869 ! cellular developmental process
relationship: part_of GO:0007338 ! single fertilization

[Term]
id: GO:0035048
name: splicing factor protein import into nucleus
namespace: biological_process
def: "The directed movement of a pre-mRNA splicing factor from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:bf]
synonym: "splicing factor protein transport from cytoplasm to nucleus" EXACT []
synonym: "splicing factor protein-nucleus import" EXACT []
is_a: GO:0006606 ! protein import into nucleus

[Term]
id: GO:0035049
name: juvenile hormone acid methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group to juvenile hormone acid." [GOC:bf]
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0035050
name: embryonic heart tube development
namespace: biological_process
def: "The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field." [GOC:go_curators]
is_a: GO:0035295 ! tube development
is_a: GO:0060429 ! epithelium development
relationship: part_of GO:0007507 ! heart development
relationship: part_of GO:0009790 ! embryo development
relationship: part_of GO:0048568 ! embryonic organ development

[Term]
id: GO:0035051
name: cardiocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual." [GOC:bf]
synonym: "cardiac cell differentiation" EXACT []
synonym: "heart cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0007507 ! heart development

[Term]
id: GO:0035052
name: dorsal vessel aortic cell fate commitment
namespace: biological_process
def: "The commitment of dorsal vessel cardioblast cells to an aortic cell fate and their capacity to differentiate into aortic cells. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12397110]
is_a: GO:0060581 ! cell fate commitment involved in pattern specification
is_a: GO:0060911 ! cardiac cell fate commitment
relationship: part_of GO:0035054 ! embryonic heart tube anterior/posterior pattern specification

[Term]
id: GO:0035053
name: dorsal vessel heart proper cell fate commitment
namespace: biological_process
def: "The commitment of dorsal vessel cardioblast cells to a heart proper cell fate and their capacity to differentiate into heart cells. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12397110]
is_a: GO:0060581 ! cell fate commitment involved in pattern specification
is_a: GO:0060911 ! cardiac cell fate commitment
relationship: part_of GO:0035054 ! embryonic heart tube anterior/posterior pattern specification

[Term]
id: GO:0035054
name: embryonic heart tube anterior/posterior pattern specification
namespace: biological_process
def: "The establishment, maintenance and elaboration of cell differentiation that results in the anterior/posterior subdivision of the embryonic heart tube. In Drosophila this results in subdivision of the dorsal vessel into to the posterior heart proper and the anterior aorta." [GOC:bf, PMID:12435360]
is_a: GO:0009952 ! anterior/posterior pattern specification
relationship: part_of GO:0035050 ! embryonic heart tube development

[Term]
id: GO:0035058
name: nonmotile primary cilium assembly
namespace: biological_process
def: "The assembly of a primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules." [GOC:kmv, PMID:14521833, PMID:14521834]
synonym: "immotile primary cilium assembly" EXACT [GOC:bf]
synonym: "nonmotile primary cilia assembly" RELATED [GOC:bf]
synonym: "sensory cilium assembly" EXACT [GOC:kmv]
synonym: "sensory cilium biogenesis" RELATED [GOC:mah]
is_a: GO:0042384 ! cilium assembly

[Term]
id: GO:0035059
name: RCAF complex
namespace: cellular_component
def: "A protein complex that facilitates the assembly of nucleosomes on to newly synthesized DNA. In Drosophila, the complex comprises ASF1 and histones H3 and H4." [GOC:bf, PMID:10591219]
synonym: "replication-coupling assembly factor complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0035060
name: brahma complex
namespace: cellular_component
def: "A SWI/SNF-type complex that contains the ATPase product of the Drosophila brahma gene, or an ortholog thereof." [GOC:bf, PMID:10809665, PMID:12482982]
synonym: "BRM complex" EXACT []
is_a: GO:0090544 ! BAF-type complex

[Term]
id: GO:0035061
name: interchromatin granule
namespace: cellular_component
def: "A class of nuclear body measuring 20-25 nm in diameter and distributed throughout the interchromatin space, linked together by thin fibrils. They are believed to be storage centers for various snRNAs, snRNPs, serine/arginine-rich proteins and RNA polymerase II. A typical mammalian cell contains 25-50 clusters of interchromatin granules. Interchromatin granule clusters do not contain the heterogeneous nuclear RNA-binding proteins (hnRNPs)." [GOC:bf, PMID:10984439]
synonym: "ICG" EXACT []
xref: NIF_Subcellular:sao1049471211
is_a: GO:0016604 ! nuclear body

[Term]
id: GO:0035062
name: omega speckle
namespace: cellular_component
def: "A nucleoplasmic speckle distributed in the interchromatin space of cells in close proximity to chromatin. Omega speckles are distinct from interchromatin granules and contain heterogeneous nuclear RNA-binding proteins (hnRNPs)." [GOC:bf, PMID:10984439]
is_a: GO:0016607 ! nuclear speck

[Term]
id: GO:0035063
name: nuclear speck organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of nuclear specks, a class of nuclear body in which splicing factors are localized." [GOC:bf, GOC:curators]
comment: See also the cellular component term 'nuclear speck ; GO:0016607'.
synonym: "nuclear speck organisation" EXACT [GOC:curators]
synonym: "nuclear speck organization and biogenesis" RELATED [GOC:mah]
synonym: "nuclear speckle assembly" NARROW [GOC:mah]
synonym: "nuclear speckle organization" EXACT []
is_a: GO:0030575 ! nuclear body organization

[Term]
id: GO:0035064
name: methylated histone binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a histone protein in which a residue has been modified by methylation. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes." [GOC:bf, PMID:14585615]
is_a: GO:0042393 ! histone binding

[Term]
id: GO:0035065
name: regulation of histone acetylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the addition of an acetyl group to a histone protein." [GOC:bf]
is_a: GO:0031056 ! regulation of histone modification
is_a: GO:2000756 ! regulation of peptidyl-lysine acetylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016573 ! histone acetylation
relationship: regulates GO:0016573 ! histone acetylation

[Term]
id: GO:0035066
name: positive regulation of histone acetylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to a histone protein." [GOC:bf]
synonym: "activation of histone acetylation" NARROW []
synonym: "stimulation of histone acetylation" NARROW []
synonym: "up regulation of histone acetylation" EXACT []
synonym: "up-regulation of histone acetylation" EXACT []
synonym: "upregulation of histone acetylation" EXACT []
is_a: GO:0031058 ! positive regulation of histone modification
is_a: GO:0035065 ! regulation of histone acetylation
is_a: GO:2000758 ! positive regulation of peptidyl-lysine acetylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016573 ! histone acetylation
relationship: positively_regulates GO:0016573 ! histone acetylation

[Term]
id: GO:0035067
name: negative regulation of histone acetylation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of an acetyl group to a histone protein." [GOC:bf]
synonym: "down regulation of histone acetylation" EXACT []
synonym: "down-regulation of histone acetylation" EXACT []
synonym: "downregulation of histone acetylation" EXACT []
synonym: "inhibition of histone acetylation" NARROW []
is_a: GO:0031057 ! negative regulation of histone modification
is_a: GO:0035065 ! regulation of histone acetylation
is_a: GO:2000757 ! negative regulation of peptidyl-lysine acetylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016573 ! histone acetylation
relationship: negatively_regulates GO:0016573 ! histone acetylation

[Term]
id: GO:0035068
name: micro-ribonucleoprotein complex
namespace: cellular_component
def: "A complex containing both protein and micro-RNA (miRNA) molecules. miRNAs are approximately 22 nucleotide noncoding RNAs derived from endogenous genes; they are processed from the stem of a longer hairpin like structure termed a pre-miRNA." [GOC:bf, PMID:14559182]
synonym: "miRNP complex" EXACT []
is_a: GO:0030529 ! intracellular ribonucleoprotein complex

[Term]
id: GO:0035069
name: larval midgut histolysis
namespace: biological_process
def: "The stage-specific break down of the larval midgut during Drosophila metamorphosis, to allow replacement of larval structures by tissues and structures that form the adult fly." [GOC:bf, GOC:dph, GOC:mtg_apoptosis, PMID:9409683]
synonym: "larval midgut regression" EXACT []
is_a: GO:0060033 ! anatomical structure regression
relationship: part_of GO:0007552 ! metamorphosis
relationship: part_of GO:0048707 ! instar larval or pupal morphogenesis

[Term]
id: GO:0035070
name: salivary gland histolysis
namespace: biological_process
def: "The stage-specific break down of the larval salivary glands during Drosophila metamorphosis, to allow replacement of larval structures by tissues and structures that form the adult fly." [GOC:bf, GOC:dph, GOC:mtg_apoptosis, PMID:9409683]
synonym: "salivary gland regression" EXACT []
is_a: GO:0007435 ! salivary gland morphogenesis
is_a: GO:0009886 ! post-embryonic morphogenesis
is_a: GO:0060033 ! anatomical structure regression
relationship: part_of GO:0007552 ! metamorphosis
relationship: part_of GO:0048707 ! instar larval or pupal morphogenesis

[Term]
id: GO:0035071
name: salivary gland cell autophagic cell death
namespace: biological_process
def: "The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130]
synonym: "autophagic cell death of salivary gland cells" EXACT []
synonym: "programmed cell death of salivary gland cells by autophagy" EXACT []
synonym: "salivary gland cell death" EXACT []
synonym: "salivary gland cell programmed cell death by autophagy" EXACT []
is_a: GO:0010623 ! developmental programmed cell death
is_a: GO:0048102 ! autophagic cell death
relationship: part_of GO:0035070 ! salivary gland histolysis

[Term]
id: GO:0035072
name: ecdysone-mediated induction of salivary gland cell autophagic cell death
namespace: biological_process
def: "Any process induced by ecdysone that directly activates salivary gland programmed cell death during salivary gland histolysis." [GOC:bf]
synonym: "ecdysone-mediated induction of autophagic cell death of salivary gland cells" EXACT []
synonym: "ecdysone-mediated induction of programmed cell death of salivary gland cells by autophagy" EXACT []
synonym: "ecdysone-mediated induction of salivary gland cell programmed cell death by autophagy" EXACT []
is_a: GO:0035078 ! induction of programmed cell death by ecdysone
relationship: part_of GO:0035071 ! salivary gland cell autophagic cell death

[Term]
id: GO:0035073
name: pupariation
namespace: biological_process
def: "The onset of prepupal development when the larval stops crawling, everts its spiracles and the larval cuticle becomes the puparium or pupal case that surrounds the organism for the duration of metamorphosis." [GOC:bf, ISBN:0879694238, PMID:9409683]
synonym: "puparium biosynthesis" EXACT []
synonym: "puparium formation" EXACT []
is_a: GO:0044707 ! single-multicellular organism process
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0035210 ! prepupal development

[Term]
id: GO:0035074
name: pupation
namespace: biological_process
def: "The act of becoming a pupa, a resting stage in the life cycle of organisms with complete metamorphosis. This event marks the end of the prepupal period and the beginning of the pupal period." [GOC:bf, ISBN:0582227089, ISBN:0879694238]
synonym: "head eversion" EXACT []
synonym: "prepupal-pupal transition" EXACT []
xref: Wikipedia:Pupa
is_a: GO:0044707 ! single-multicellular organism process
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0035209 ! pupal development

[Term]
id: GO:0035075
name: response to ecdysone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ecdysone stimulus." [GOC:bf]
is_a: GO:0036314 ! response to sterol
is_a: GO:1901654 ! response to ketone

[Term]
id: GO:0035076
name: ecdysone receptor-mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals generated by ecdysone binding to the ecdysone receptor complex." [GOC:bf]
synonym: "ecdysone receptor-mediated signalling pathway" EXACT []
is_a: GO:0030518 ! intracellular steroid hormone receptor signaling pathway
relationship: part_of GO:0071390 ! cellular response to ecdysone

[Term]
id: GO:0035077
name: ecdysone-mediated polytene chromosome puffing
namespace: biological_process
def: "The decondensing (loosening) and swelling of the chromosomal sites of hormone-responsive genes on polytene chromosomes in response to increased production of the steroid hormone 20-hydroxyecdysone (ecdysone) in Drosophila larvae approaching pupation." [GOC:bf, PMID:12543962]
is_a: GO:0035079 ! polytene chromosome puffing
is_a: GO:1902589 ! single-organism organelle organization
relationship: part_of GO:0071390 ! cellular response to ecdysone

[Term]
id: GO:0035078
name: induction of programmed cell death by ecdysone
namespace: biological_process
def: "Any process induced by the steroid hormone 20-hydroxyecdysone (ecdysone) that directly activates any of the steps required for programmed cell death." [GOC:bf]
is_a: GO:0035081 ! induction of programmed cell death by hormones
relationship: part_of GO:0035075 ! response to ecdysone

[Term]
id: GO:0035079
name: polytene chromosome puffing
namespace: biological_process
def: "The decondensing (loosening) and swelling of the chromosomal sites of target genes on polytene chromosomes following response to a stimulus, to facilitate sudden bursts of transcriptional activity in response to transient environmental signals." [GOC:bf, PMID:12543962]
is_a: GO:0051276 ! chromosome organization

[Term]
id: GO:0035080
name: heat shock-mediated polytene chromosome puffing
namespace: biological_process
def: "The decondensing (loosening) and swelling of the chromosomal sites of heat shock genes on polytene chromosomes in response to a heat shock stimulus." [GOC:bf, PMID:12543962]
is_a: GO:0034605 ! cellular response to heat
is_a: GO:0035079 ! polytene chromosome puffing
is_a: GO:1902589 ! single-organism organelle organization

[Term]
id: GO:0035081
name: induction of programmed cell death by hormones
namespace: biological_process
def: "Any process induced by hormones that directly activates any of the steps required for programmed cell death." [GOC:bf]
is_a: GO:0012502 ! induction of programmed cell death

[Term]
id: GO:0035082
name: axoneme assembly
namespace: biological_process
alt_id: GO:0035083
alt_id: GO:0035084
def: "The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, GOC:jl, ISBN:0815316194]
comment: Note that cilia and eukaryotic flagella are deemed to be equivalent.
synonym: "axoneme biogenesis" RELATED [GOC:mah]
synonym: "ciliary axoneme assembly" EXACT []
synonym: "cilium axoneme assembly" EXACT []
synonym: "cilium axoneme biogenesis" RELATED [GOC:mah]
synonym: "flagellar axoneme assembly" EXACT []
synonym: "flagellum axoneme assembly" EXACT []
is_a: GO:0001578 ! microtubule bundle formation
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
is_a: GO:0030031 ! cell projection assembly
relationship: part_of GO:0042384 ! cilium assembly

[Term]
id: GO:0035087
name: siRNA loading onto RISC involved in RNA interference
namespace: biological_process
def: "The transfer of small interfering RNA molecules (siRNAs) from the Dicer family of enzymes that cleave the double-stranded RNA, onto the nuclease-containing RNA-initiated silencing complex (RISC), in the context of RNA interference." [GOC:bf, GOC:mah, PMID:14512631]
synonym: "RNA interference, siRNA loading onto RISC" EXACT [GOC:mah]
is_a: GO:0070922 ! small RNA loading onto RISC
relationship: part_of GO:0016246 ! RNA interference

[Term]
id: GO:0035088
name: establishment or maintenance of apical/basal cell polarity
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance polarization of a cell's architecture along its apical/basal axis so that the apical and basal regions of the cell have different membrane, extracellular matrix and sub-membrane cellular components." [GOC:bf, GOC:mah, PMID:10934483]
is_a: GO:0061245 ! establishment or maintenance of bipolar cell polarity

[Term]
id: GO:0035089
name: establishment of apical/basal cell polarity
namespace: biological_process
def: "The specification and formation of the polarity of a cell along its apical/basal axis." [GOC:bf]
is_a: GO:0035088 ! establishment or maintenance of apical/basal cell polarity
is_a: GO:0061162 ! establishment of monopolar cell polarity

[Term]
id: GO:0035090
name: maintenance of apical/basal cell polarity
namespace: biological_process
def: "Retaining the established polarization of a cell along its apical/basal axis." [GOC:bf]
is_a: GO:0030011 ! maintenance of cell polarity
is_a: GO:0035088 ! establishment or maintenance of apical/basal cell polarity

[Term]
id: GO:0035091
name: phosphatidylinositol binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]
synonym: "phosphoinositide binding" EXACT [GOC:curators]
is_a: GO:0005543 ! phospholipid binding

[Term]
id: GO:0035092
name: sperm chromatin condensation
namespace: biological_process
def: "The progressive compaction of the spermatid chromatin so that it reaches a level of condensation that is not compatible with nuclear activities such as transcription or DNA replication." [GOC:bf, PMID:11735001]
is_a: GO:0006259 ! DNA metabolic process
is_a: GO:0006323 ! DNA packaging
is_a: GO:0006325 ! chromatin organization
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0044710 ! single-organism metabolic process
is_a: GO:1902589 ! single-organism organelle organization
relationship: part_of GO:0007289 ! spermatid nucleus differentiation

[Term]
id: GO:0035093
name: spermatogenesis, exchange of chromosomal proteins
namespace: biological_process
def: "The replacement of somatic histones within sperm chromatin with sperm-specific histones or protamines with unique DNA-binding properties, resulting in condensation of the sperm chromatin." [GOC:bf, PMID:11735001]
synonym: "somatic histone exchange" EXACT []
synonym: "somatic histone replacement" RELATED []
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0043486 ! histone exchange
is_a: GO:1902589 ! single-organism organelle organization
relationship: part_of GO:0035092 ! sperm chromatin condensation

[Term]
id: GO:0035094
name: response to nicotine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus." [CHEBI:17688, GOC:bf, GOC:ef, ISBN:0198506732, ISBN:0582227089]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0043279 ! response to alkaloid

[Term]
id: GO:0035095
name: behavioral response to nicotine
namespace: biological_process
def: "Any process that results in a change in the behavior of an organism as a result of a nicotine stimulus." [GOC:bf, ISBN:0198506732]
synonym: "behavioural response to nicotine" EXACT []
is_a: GO:0030534 ! adult behavior
relationship: part_of GO:0035094 ! response to nicotine

[Term]
id: GO:0035096
name: larval midgut cell programmed cell death
namespace: biological_process
def: "The stage-specific programmed cell death of cells of the larval midgut, during histolysis of the larval organ." [GOC:bf, GOC:mtg_apoptosis]
synonym: "larval midgut cell death" EXACT []
synonym: "programmed cell death of larval midgut cells" EXACT []
is_a: GO:0010623 ! developmental programmed cell death
relationship: part_of GO:0035069 ! larval midgut histolysis

[Term]
id: GO:0035097
name: histone methyltransferase complex
namespace: cellular_component
def: "A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins." [GOC:bf]
subset: goslim_pir
is_a: GO:0034708 ! methyltransferase complex
is_a: GO:0044451 ! nucleoplasm part

[Term]
id: GO:0035098
name: ESC/E(Z) complex
namespace: cellular_component
def: "A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4." [GOC:bf, GOC:sp, PMID:12408863, PMID:12408864, PMID:20064375]
synonym: "Extra Sex Combs/Enhancer of Zeste complex" EXACT []
synonym: "PRC2 complex" EXACT [GOC:sp, PMID:20064375]
is_a: GO:0031519 ! PcG protein complex
is_a: GO:0035097 ! histone methyltransferase complex

[Term]
id: GO:0035099
name: hemocyte migration
namespace: biological_process
def: "The directed movement of a hemocyte within the embryo. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. In Drosophila, embryonic hemocytes originate from the head mesoderm as a cluster of cells. The cluster splits into two and one group of cells crosses the amnioserosa. Both populations then spread toward the middle of the embryo and then disperse evenly throughout the embryo." [GOC:bf, GOC:mtg_sensu, PMID:12885551]
synonym: "arthropod blood cell migration" EXACT []
synonym: "hemocyte cell migration" EXACT []
is_a: GO:0016477 ! cell migration
relationship: part_of GO:0035162 ! embryonic hemopoiesis

[Term]
id: GO:0035100
name: ecdysone binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with 20-hydroxyecdysone (ecdysone). Ecdysone is an ecdysteroid produced by the prothoracic glands of immature insects and the ovaries of adult females, which stimulates growth and molting." [GOC:bf, ISBN:0198506732, ISBN:0582227089]
is_a: GO:0032934 ! sterol binding
is_a: GO:0042562 ! hormone binding

[Term]
id: GO:0035101
name: FACT complex
namespace: cellular_component
def: "An abundant nuclear complex, which was originally identified in mammalian systems as a factor required for transcription elongation on chromatin templates. The FACT complex has been shown to destablilize the interaction between the H2A/H2B dimer and the H3/H4 tetramer of the nucleosome, thus reorganizing the structure of the nucleosome. In this way, the FACT complex may play a role in DNA replication and other processes that traverse the chromatin, as well as in transcription elongation. FACT is composed of two proteins that are evolutionarily conserved in all eukaryotes and homologous to mammalian Spt16 and SSRP1. In metazoans, the SSRP1 homolog contains an HMG domain; however in fungi and protists, it does not. For example, in S. cerevisiae the Pob3 protein is homologous to SSRP1, but lacks the HMG chromatin binding domain. Instead, the yFACT complex of Spt16p and Pob3p, binds to nucleosomes where multiple copies of the HMG-domain containing protein Nhp6p have already bound, but Nhp6p does not form a stable complex with the Spt16p/Pob3p heterodimer." [GOC:bf, GOC:expert_ks, GOC:expert_ras, GOC:expert_tf, GOC:krc, PMID:12934006, PMID:12934007, PMID:16678108]
synonym: "Facilitates chromatin transcription complex" EXACT []
is_a: GO:0008023 ! transcription elongation factor complex

[Term]
id: GO:0035102
name: PRC1 complex
namespace: cellular_component
def: "A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling." [GOC:bf, PMID:10412979]
comment: In Drosophila the core subunits are Pc (Polycomb), Psc (Posterior sex combs), Ph (Polyhomeotic) and Sce (Sex comb extra). In mammals, which have several orthologs for each of the Drosophila core proteins, a family of distinct PRC1-like complexes seem to exist which contain at least some PcG proteins in mutually exclusive manner.
synonym: "Polycomb repressive complex 1" EXACT []
is_a: GO:0000152 ! nuclear ubiquitin ligase complex
is_a: GO:0031519 ! PcG protein complex

[Term]
id: GO:0035103
name: sterol regulatory element binding protein cleavage
namespace: biological_process
alt_id: GO:0006992
def: "The proteolytic release of a transcriptionally active sterol regulatory element binding protein (SREBP) from intracellular membranes, freeing it to move to the nucleus to upregulate transcription of target genes, in response to altered levels of one or more lipids." [GOC:bf, GOC:vw, PMID:12923525]
synonym: "SREBP cleavage" EXACT []
synonym: "sterol depletion response, SREBP cleavage" EXACT []
synonym: "sterol regulatory element binding protein cleavage involved in ER-nuclear sterol response pathway" NARROW [GOC:vw]
is_a: GO:0016485 ! protein processing
is_a: GO:0044267 ! cellular protein metabolic process
relationship: part_of GO:0032933 ! SREBP signaling pathway

[Term]
id: GO:0035105
name: sterol regulatory element binding protein import into nucleus
namespace: biological_process
alt_id: GO:0006993
def: "The transfer of a sterol regulatory element binding protein (SREBP) into the nucleus, across the nuclear membrane, in response to altered levels of one or more lipids. SREBPs are transcription factors that bind sterol regulatory elements (SREs), DNA motifs found in the promoters of target genes." [GOC:bf, GOC:vw, PMID:12923525]
comment: Note that 'translocation' is sometimes used in the literature to refer to the entire process of protein import into the nucleus, but in GO refers specifically to the step in which a cargo-carrier protein complex moves through the nuclear pore complex.
synonym: "SREBP import into nucleus" EXACT [GOC:mah]
synonym: "SREBP import into nucleus involved in sterol depletion response" EXACT [GOC:mah]
synonym: "SREBP nuclear translocation" NARROW [GOC:mah]
synonym: "sterol depletion response, SREBP import into nucleus" EXACT [GOC:mah]
synonym: "sterol depletion response, SREBP nuclear translocation" NARROW [GOC:mah]
synonym: "sterol depletion response, sterol regulatory element binding protein import into nucleus" EXACT []
synonym: "sterol depletion response, sterol regulatory element binding protein nuclear translocation" NARROW [GOC:dph, GOC:mah, GOC:tb]
synonym: "sterol regulatory element binding protein import into nucleus involved in sterol depletion response" NARROW [GOC:vw]
synonym: "sterol regulatory element binding protein nuclear translocation" NARROW [GOC:mah]
synonym: "sterol regulatory element binding protein nuclear translocation involved in sterol depletion response" NARROW [GOC:mah]
is_a: GO:0006606 ! protein import into nucleus
relationship: part_of GO:0032933 ! SREBP signaling pathway

[Term]
id: GO:0035106
name: operant conditioning
namespace: biological_process
def: "Learning to anticipate future events on the basis of past experience with the consequences of one's own behavior." [PMID:14662373]
synonym: "instrumental conditioning" EXACT []
xref: Wikipedia:Operant_conditioning
is_a: GO:0007612 ! learning

[Term]
id: GO:0035107
name: appendage morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of appendages are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch." [ISBN:0582227089]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0048736 ! appendage development

[Term]
id: GO:0035108
name: limb morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a limb are generated and organized. A limb is a paired appendage of a tetrapod used for locomotion or grasping." [UBERON:0002101]
synonym: "limb bud morphogenesis" NARROW [GOC:dph]
is_a: GO:0035107 ! appendage morphogenesis
relationship: part_of GO:0060173 ! limb development

[Term]
id: GO:0035109
name: obsolete imaginal disc-derived limb morphogenesis
namespace: biological_process
def: "OBSOLETE. The process in which the anatomical structures of limbs that are derived from an imaginal disc are generated and organized. A limb is an appendage of an animal used for locomotion or grasping. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
comment: This term was made obsolete because the term 'limb' is not widely used in the insect community. In GO, 'limb' is used to describe the vertebrate hindlimbs and forelimbs.
synonym: "imaginal disc-derived limb morphogenesis" EXACT []
is_obsolete: true
consider: GO:0035114

[Term]
id: GO:0035110
name: obsolete leg morphogenesis
namespace: biological_process
def: "OBSOLETE. The process in which the anatomical structures of a leg are generated and organized. A leg is a limb on which an animal walks and stands." [GOC:bf, ISBN:0198612001]
comment: This term was made obsolete because leg is a mechano-functional grouping, and having both 'leg morphogenesis' and 'hindlimb morphogenesis' terms causes errors in querying.
synonym: "leg morphogenesis" EXACT []
is_obsolete: true
consider: GO:0007480
consider: GO:0035108
consider: GO:0035137

[Term]
id: GO:0035111
name: obsolete leg joint morphogenesis
namespace: biological_process
def: "OBSOLETE. The process in which the anatomical structures of a leg joint are generated and organized. The leg joint is a flexible region that separates the rigid sections of a leg to allow movement in a controlled manner. One example is the knee, which separates the leg tibia and femur." [GOC:bf, ISBN:0582227089, PMID:12051824]
comment: This term was made obsolete because leg is a mechano-functional grouping, and having both 'leg morphogenesis' and 'hindlimb morphogenesis' terms causes errors in querying.
synonym: "leg joint morphogenesis" EXACT []
is_obsolete: true
consider: GO:0016348
consider: GO:0036023

[Term]
id: GO:0035112
name: genitalia morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of genitalia are generated and organized. The genitalia are the organs of reproduction or generation, external and internal." [GOC:bf]
synonym: "genital morphogenesis" RELATED []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0009887 ! organ morphogenesis
is_a: GO:0044702 ! single organism reproductive process
relationship: part_of GO:0048806 ! genitalia development

[Term]
id: GO:0035113
name: embryonic appendage morphogenesis
namespace: biological_process
def: "The process, occurring in the embryo, by which the anatomical structures of the appendage are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch." [ISBN:0582227089]
is_a: GO:0035107 ! appendage morphogenesis
is_a: GO:0048598 ! embryonic morphogenesis

[Term]
id: GO:0035114
name: imaginal disc-derived appendage morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of appendages are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism." [GOC:mtg_sensu, ISBN:0582227089]
is_a: GO:0035107 ! appendage morphogenesis
relationship: part_of GO:0048737 ! imaginal disc-derived appendage development

[Term]
id: GO:0035115
name: embryonic forelimb morphogenesis
namespace: biological_process
alt_id: GO:0035117
def: "The process, occurring in the embryo, by which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human." [ISBN:0198612001]
synonym: "embryonic arm morphogenesis" NARROW [GOC:bf, GOC:cjm]
is_a: GO:0030326 ! embryonic limb morphogenesis
is_a: GO:0035136 ! forelimb morphogenesis

[Term]
id: GO:0035116
name: embryonic hindlimb morphogenesis
namespace: biological_process
def: "The process, occurring in the embryo, by which the anatomical structures of the hindlimbs are generated and organized. The hindlimbs are the posterior limbs of an animal." [ISBN:0198612001]
is_a: GO:0030326 ! embryonic limb morphogenesis
is_a: GO:0035137 ! hindlimb morphogenesis

[Term]
id: GO:0035118
name: embryonic pectoral fin morphogenesis
namespace: biological_process
def: "The process, occurring in the embryo, by which the anatomical structures of the pectoral fin are generated and organized. Pectoral fins are bilaterally paired fins mounted laterally and located behind the gill covers of fish. These fins are used for lateral mobility and propulsion." [GOC:dgh]
is_a: GO:0035113 ! embryonic appendage morphogenesis
is_a: GO:0035138 ! pectoral fin morphogenesis

[Term]
id: GO:0035119
name: embryonic pelvic fin morphogenesis
namespace: biological_process
def: "The process, occurring in the embryo, by which the anatomical structures of the pelvic fin are generated and organized. The pelvic fins are bilaterally paired fins mounted in a ventral-lateral position on most fish. These fins are used primarily for lateral mobility and propulsion." [GOC:dgh]
is_a: GO:0035113 ! embryonic appendage morphogenesis
is_a: GO:0035139 ! pelvic fin morphogenesis

[Term]
id: GO:0035120
name: post-embryonic appendage morphogenesis
namespace: biological_process
def: "The process, occurring after embryonic development, by which the anatomical structures of an appendage are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch." [ISBN:0582227089]
is_a: GO:0009886 ! post-embryonic morphogenesis
is_a: GO:0035107 ! appendage morphogenesis

[Term]
id: GO:0035121
name: obsolete tail morphogenesis
namespace: biological_process
def: "OBSOLETE. The process in which the anatomical structures of the tail are generated and organized. The tail is the hindmost part of some animals." [ISBN:0198612001]
comment: This term was made obsolete because 'tail' has different meanings in different organisms, and is therefore not a useful grouping term.
synonym: "tail morphogenesis" EXACT []
is_obsolete: true
consider: GO:0003002
consider: GO:0036342
consider: GO:0048809

[Term]
id: GO:0035122
name: embryonic medial fin morphogenesis
namespace: biological_process
def: "The process, occurring in the embryo, by which the anatomical structures of the medial fin are generated and organized. Medial fins are unpaired fins of fish, usually located dorsomedially or ventromedially and primarily used for stability while swimming." [GOC:dgh]
synonym: "embryonic unpaired fin morphogenesis" EXACT []
is_a: GO:0035113 ! embryonic appendage morphogenesis
is_a: GO:0035141 ! medial fin morphogenesis

[Term]
id: GO:0035123
name: embryonic dorsal fin morphogenesis
namespace: biological_process
def: "The process, occurring in the embryo, by which the anatomical structures of the dorsal fin are generated and organized. A dorsal fin is an unpaired medial fin on the dorsal aspect of a fish that provides lateral stability while swimming. Generally fish have one or two dorsal fins." [GOC:dgh]
is_a: GO:0035122 ! embryonic medial fin morphogenesis
is_a: GO:0035142 ! dorsal fin morphogenesis

[Term]
id: GO:0035124
name: embryonic caudal fin morphogenesis
namespace: biological_process
def: "The process, occurring in the embryo, by which the anatomical structures of the caudal fin are generated and organized. The caudal fin is an unpaired medial fin mounted at the caudal end of the fish and is the main fin used for propulsion." [GOC:dgh]
is_a: GO:0035122 ! embryonic medial fin morphogenesis
is_a: GO:0035143 ! caudal fin morphogenesis

[Term]
id: GO:0035125
name: embryonic anal fin morphogenesis
namespace: biological_process
def: "The process, occurring in the embryo, by which the anatomical structures of the embryonic anal fin are generated and organized. An anal fin is an unpaired medial fin on the ventral aspect near the caudal end of a fish, which provides lateral stability while swimming." [GOC:dgh]
is_a: GO:0035122 ! embryonic medial fin morphogenesis
is_a: GO:0035144 ! anal fin morphogenesis

[Term]
id: GO:0035126
name: post-embryonic genitalia morphogenesis
namespace: biological_process
def: "The process, occurring after embryonic development, by which the anatomical structures of the genitalia are generated and organized." [GOC:bf]
synonym: "post-embryonic genital morphogenesis" RELATED []
is_a: GO:0035112 ! genitalia morphogenesis
is_a: GO:0048563 ! post-embryonic organ morphogenesis

[Term]
id: GO:0035127
name: post-embryonic limb morphogenesis
namespace: biological_process
def: "The process, occurring after embryonic development, by which the anatomical structures of the limb are generated and organized. A limb is an appendage of an animal used for locomotion or grasping." [ISBN:0395825172]
is_a: GO:0035108 ! limb morphogenesis
is_a: GO:0035120 ! post-embryonic appendage morphogenesis

[Term]
id: GO:0035128
name: post-embryonic forelimb morphogenesis
namespace: biological_process
def: "The process, occurring after embryonic development, by which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an organism." [GOC:bf]
is_a: GO:0035127 ! post-embryonic limb morphogenesis
is_a: GO:0035136 ! forelimb morphogenesis

[Term]
id: GO:0035129
name: post-embryonic hindlimb morphogenesis
namespace: biological_process
def: "The process, occurring after embryonic development, by which the anatomical structures of the hindlimb are generated and organized." [GOC:bf]
is_a: GO:0035127 ! post-embryonic limb morphogenesis
is_a: GO:0035137 ! hindlimb morphogenesis

[Term]
id: GO:0035130
name: post-embryonic pectoral fin morphogenesis
namespace: biological_process
def: "The process, occurring after embryonic development, by which the anatomical structures of the pectoral fin are generated and organized. Pectoral fins are bilaterally paired fins mounted laterally and located behind the gill covers of fish. These fins are used for lateral mobility and propulsion." [GOC:dgh]
is_a: GO:0035120 ! post-embryonic appendage morphogenesis
is_a: GO:0035138 ! pectoral fin morphogenesis

[Term]
id: GO:0035131
name: post-embryonic pelvic fin morphogenesis
namespace: biological_process
def: "The process, occurring after embryonic development, by which the anatomical structures of the pelvic fin are generated and organized. The pelvic fins are bilaterally paired fins mounted in a ventral-lateral position on most fish. These fins are used primarily for lateral mobility and propulsion." [GOC:dgh]
is_a: GO:0035120 ! post-embryonic appendage morphogenesis
is_a: GO:0035139 ! pelvic fin morphogenesis

[Term]
id: GO:0035132
name: post-embryonic medial fin morphogenesis
namespace: biological_process
def: "The process, occurring after embryonic development, by which the anatomical structures of the medial fin are generated and organized. Medial fins are unpaired fins of fish, usually located dorsomedially or ventromedially and primarily used for stability while swimming." [GOC:dgh]
synonym: "post-embryonic unpaired fin morphogenesis" EXACT []
is_a: GO:0035120 ! post-embryonic appendage morphogenesis
is_a: GO:0035141 ! medial fin morphogenesis

[Term]
id: GO:0035133
name: post-embryonic caudal fin morphogenesis
namespace: biological_process
def: "The process, occurring after embryonic development, by which the anatomical structures of the caudal fin are generated and organized. The caudal fin is an unpaired medial fin mounted at the caudal end of the fish and is the main fin used for propulsion." [GOC:dgh]
is_a: GO:0035132 ! post-embryonic medial fin morphogenesis
is_a: GO:0035143 ! caudal fin morphogenesis

[Term]
id: GO:0035134
name: post-embryonic dorsal fin morphogenesis
namespace: biological_process
def: "The process, occurring after embryonic development, by which the anatomical structures of the dorsal fin are generated and organized. A dorsal fin is an unpaired medial fin on the dorsal aspect of a fish that provides lateral stability while swimming. Generally fish have one or two dorsal fins." [GOC:dgh]
is_a: GO:0035132 ! post-embryonic medial fin morphogenesis
is_a: GO:0035142 ! dorsal fin morphogenesis

[Term]
id: GO:0035135
name: post-embryonic anal fin morphogenesis
namespace: biological_process
def: "The process, occurring after embryonic development, by which the anatomical structures of the anal fin are generated and organized. An anal fin is an unpaired medial fin on the ventral aspect near the caudal end of a fish, which provides lateral stability while swimming." [GOC:dgh]
is_a: GO:0035132 ! post-embryonic medial fin morphogenesis
is_a: GO:0035144 ! anal fin morphogenesis

[Term]
id: GO:0035136
name: forelimb morphogenesis
namespace: biological_process
alt_id: GO:0035140
def: "The process in which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human." [GOC:go_curators]
synonym: "arm morphogenesis" NARROW [GOC:bf, GOC:cjm]
is_a: GO:0035108 ! limb morphogenesis

[Term]
id: GO:0035137
name: hindlimb morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the hindlimb are generated and organized." [GOC:go_curators]
is_a: GO:0035108 ! limb morphogenesis

[Term]
id: GO:0035138
name: pectoral fin morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the pectoral fin are generated and organized. Pectoral fins are bilaterally paired fins mounted laterally and located behind the gill covers of fish. These fins are used for lateral mobility and propulsion." [GOC:dgh]
is_a: GO:0033334 ! fin morphogenesis
relationship: part_of GO:0033339 ! pectoral fin development

[Term]
id: GO:0035139
name: pelvic fin morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the pelvic fin are generated and organized. Pelvic fins are bilaterally paired fins mounted in a ventral-lateral position on most fish. These fins are used primarily for lateral mobility and propulsion." [GOC:dgh]
is_a: GO:0033334 ! fin morphogenesis
relationship: part_of GO:0033340 ! pelvic fin development

[Term]
id: GO:0035141
name: medial fin morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the medial fin are generated and organized. A medial fin is an unpaired fin of fish, usually located dorsomedially or ventromedially and primarily used for stability while swimming." [GOC:dgh]
synonym: "unpaired fin morphogenesis" EXACT []
is_a: GO:0033334 ! fin morphogenesis
relationship: part_of GO:0033338 ! medial fin development

[Term]
id: GO:0035142
name: dorsal fin morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the dorsal fin are generated and organized. A dorsal fin is an unpaired medial fin on the dorsal aspect of fish that provides lateral stability while swimming. Generally fish have one or two dorsal fins." [GOC:dgh]
is_a: GO:0035141 ! medial fin morphogenesis
relationship: part_of GO:0033337 ! dorsal fin development

[Term]
id: GO:0035143
name: caudal fin morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the caudal fin are generated and organized. A caudal fin is an unpaired medial fin mounted at the caudal end of the fish, and is the main fin used for propulsion." [GOC:dgh]
is_a: GO:0035141 ! medial fin morphogenesis
relationship: part_of GO:0033336 ! caudal fin development

[Term]
id: GO:0035144
name: anal fin morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the anal fin are generated and organized. An anal fin is an unpaired medial fin on the ventral aspect near the caudal end of a fish, which provides lateral stability while swimming." [GOC:dgh]
is_a: GO:0035141 ! medial fin morphogenesis
relationship: part_of GO:0033335 ! anal fin development

[Term]
id: GO:0035145
name: exon-exon junction complex
namespace: cellular_component
def: "A multi-subunit complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay." [PMID:11532962, PMID:11743026]
synonym: "EJC" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0035146
name: tube fusion
namespace: biological_process
def: "The joining of specific branches of a tubular system to form a continuous network." [GOC:bf]
is_a: GO:0035239 ! tube morphogenesis
relationship: part_of GO:0048754 ! branching morphogenesis of an epithelial tube

[Term]
id: GO:0035147
name: branch fusion, open tracheal system
namespace: biological_process
def: "Fusing of specific tracheal branches in an open tracheal system to branches from neighboring hemisegments to form a continuous tracheal network. Branch fusion is mediated by individual cells at the tip of each branch, which contact a similar cell and undergo a coordinated series of morphogenetic events that create a bicellular fusion joint." [GOC:mtg_sensu, PMID:14570584]
synonym: "tracheal branch fusion" EXACT []
is_a: GO:0035146 ! tube fusion
relationship: part_of GO:0060446 ! branching involved in open tracheal system development

[Term]
id: GO:0035148
name: tube formation
namespace: biological_process
def: "Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow." [GOC:bf]
synonym: "lumen formation in an anatomical structure" RELATED [GOC:dph, GOC:mah]
synonym: "tube lumen formation" EXACT [GOC:dph, GOC:mah]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0035239 ! tube morphogenesis

[Term]
id: GO:0035149
name: lumen formation, open tracheal system
namespace: biological_process
def: "Creation of the central hole of a tube in an open tracheal system through which gases flow." [GOC:bf, GOC:mtg_sensu]
synonym: "tracheal lumen formation" EXACT []
is_a: GO:0035148 ! tube formation
is_a: GO:0035152 ! regulation of tube architecture, open tracheal system

[Term]
id: GO:0035150
name: regulation of tube size
namespace: biological_process
def: "Ensuring that a tube is of the correct length and diameter. Tube size must be maintained not only during tube formation, but also throughout development and in some physiological processes." [PMID:10887083]
is_a: GO:0090066 ! regulation of anatomical structure size

[Term]
id: GO:0035151
name: regulation of tube size, open tracheal system
namespace: biological_process
def: "Ensuring that an epithelial tube in an open tracheal system is of the correct length and diameter. Tracheal tubes undergo highly regulated tube-size increases during development, expanding up to 40 times their initial size by the end of larval life. Tube size appears to be controlled by regulation of apical membrane expansion and secretion, rather than by changes in cell number, size or shape." [GOC:mtg_sensu, PMID:10887083, PMID:12930776, PMID:12973360]
synonym: "regulation of tracheal tube size" EXACT []
is_a: GO:0035150 ! regulation of tube size
is_a: GO:0035152 ! regulation of tube architecture, open tracheal system
intersection_of: GO:0035150 ! regulation of tube size
intersection_of: part_of GO:0007424 ! open tracheal system development
relationship: part_of GO:0007424 ! open tracheal system development

[Term]
id: GO:0035152
name: regulation of tube architecture, open tracheal system
namespace: biological_process
def: "Ensuring that tracheal cells form and maintain tubular structures with the correct size and shape for their position in the network. This is essential for efficient flow of gases through the tracheal network." [GOC:mtg_sensu, PMID:14570584]
synonym: "regulation of tracheal tube architecture" EXACT []
is_a: GO:0065008 ! regulation of biological quality
relationship: part_of GO:0007424 ! open tracheal system development

[Term]
id: GO:0035153
name: epithelial cell type specification, open tracheal system
namespace: biological_process
def: "Allocation of epithelial cells within each migrating branch in an open tracheal system to distinct tracheal cell fates. During the migration phase each branch forms a well-defined number of cell types (including fusion cells, terminal cells and branch cells) at precise positions." [GOC:mtg_sensu, PMID:10684581, PMID:11063940]
synonym: "tracheal cell type specification" BROAD []
synonym: "tracheal epithelial cell type specification" EXACT []
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0007424 ! open tracheal system development

[Term]
id: GO:0035154
name: terminal cell fate specification, open tracheal system
namespace: biological_process
def: "The process in which a cell in an open tracheal system becomes capable of differentiating autonomously into a terminal cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. Terminal cells send long and bifurcated hollow branches toward target tissues to allow oxygen exchange." [GOC:mtg_sensu, PMID:10684581, PMID:11063940]
synonym: "terminal cell fate specification" EXACT []
is_a: GO:0035153 ! epithelial cell type specification, open tracheal system

[Term]
id: GO:0035155
name: negative regulation of terminal cell fate specification, open tracheal system
namespace: biological_process
def: "Any process that restricts, stops or prevents a cell from adopting a terminal cell fate in an open tracheal system. Once the terminal and fusion fates have been correctly induced, inhibitory feedback loops prevent the remaining branch cells from assuming similar fates." [GOC:mtg_sensu, PMID:10684581]
synonym: "down regulation of terminal cell fate specification" EXACT []
synonym: "down-regulation of terminal cell fate specification" EXACT []
synonym: "downregulation of terminal cell fate specification" EXACT []
synonym: "inhibition of terminal cell fate specification" NARROW []
synonym: "negative regulation of terminal cell fate specification" EXACT []
is_a: GO:0009996 ! negative regulation of cell fate specification
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035154 ! terminal cell fate specification, open tracheal system
relationship: negatively_regulates GO:0035154 ! terminal cell fate specification, open tracheal system

[Term]
id: GO:0035156
name: fusion cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a fusion cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. Fusion cells allow the interconnection of adjacent tracheal metameres during tracheal tube fusion." [PMID:11063940]
is_a: GO:0035153 ! epithelial cell type specification, open tracheal system

[Term]
id: GO:0035157
name: negative regulation of fusion cell fate specification
namespace: biological_process
def: "Any process that restricts, stops or prevents a cell from adopting a fusion cell fate. Once the terminal and fusion fates have been correctly induced, inhibitory feedback loops prevent the remaining branch cells from assuming similar fates." [PMID:10684581]
synonym: "down regulation of fusion cell fate specification" EXACT []
synonym: "down-regulation of fusion cell fate specification" EXACT []
synonym: "downregulation of fusion cell fate specification" EXACT []
synonym: "inhibition of fusion cell fate specification" NARROW []
is_a: GO:0009996 ! negative regulation of cell fate specification
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035156 ! fusion cell fate specification
relationship: negatively_regulates GO:0035156 ! fusion cell fate specification

[Term]
id: GO:0035158
name: regulation of tube diameter, open tracheal system
namespace: biological_process
def: "Ensuring that a tube in an open tracheal system is of the correct diameter. When primary branches form their lumens are small (less than 2 micrometers) in caliber and must undergo regulated expansion during larval life to reach their mature size." [GOC:mtg_sensu, PMID:14570584]
synonym: "regulation of tracheal tube diameter" EXACT []
synonym: "tracheal tube dilation" NARROW []
synonym: "tracheal tube expansion" NARROW []
is_a: GO:0035159 ! regulation of tube length, open tracheal system
is_a: GO:0035296 ! regulation of tube diameter

[Term]
id: GO:0035159
name: regulation of tube length, open tracheal system
namespace: biological_process
def: "Ensuring that a tube in an open tracheal system is of the correct length." [GOC:bf, GOC:mtg_sensu]
synonym: "regulation of tracheal tube length" EXACT []
synonym: "tracheal tube elongation" NARROW []
is_a: GO:0035151 ! regulation of tube size, open tracheal system

[Term]
id: GO:0035160
name: maintenance of epithelial integrity, open tracheal system
namespace: biological_process
def: "Ensuring that tracheal tubes in an open tracheal system maintain their epithelial structure during the cell shape changes and movements that occur during the branching process." [GOC:mtg_sensu, PMID:10694415, PMID:14681183]
synonym: "maintenance of tracheal epithelial integrity" EXACT []
is_a: GO:0010669 ! epithelial structure maintenance
is_a: GO:0035152 ! regulation of tube architecture, open tracheal system

[Term]
id: GO:0035161
name: imaginal disc lineage restriction
namespace: biological_process
def: "Formation and/or maintenance of a lineage boundary between compartments in an imaginal disc that cells cannot cross, thus separating the populations of cells in each compartment." [GOC:bf, PMID:10625531, PMID:9374402]
is_a: GO:0007389 ! pattern specification process
relationship: part_of GO:0007447 ! imaginal disc pattern formation

[Term]
id: GO:0035162
name: embryonic hemopoiesis
namespace: biological_process
def: "The stages of blood cell formation that take place within the embryo." [GOC:bf]
synonym: "embryonic haematopoiesis" EXACT []
synonym: "embryonic haemopoiesis" EXACT []
synonym: "embryonic hematopoiesis" EXACT []
is_a: GO:0030097 ! hemopoiesis
is_a: GO:0048568 ! embryonic organ development

[Term]
id: GO:0035163
name: embryonic hemocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell derived from the embryonic head mesoderm acquires the specialized features of a mature hemocyte. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu, PMID:14602069]
synonym: "embryonic arthropod blood cell differentiation" EXACT []
synonym: "embryonic hemocyte cell differentiation" EXACT []
is_a: GO:0042386 ! hemocyte differentiation
relationship: part_of GO:0035162 ! embryonic hemopoiesis

[Term]
id: GO:0035164
name: embryonic plasmatocyte differentiation
namespace: biological_process
def: "The process in which an embryonic mesoderm-derived hemocyte precursor cell acquires the specialized features of the phagocytic blood-cell type, the plasmatocyte." [GOC:bf, PMID:11921077, PMID:8174791]
synonym: "embryonic plasmatocyte cell differentiation" EXACT []
is_a: GO:0035163 ! embryonic hemocyte differentiation
is_a: GO:0042387 ! plasmatocyte differentiation

[Term]
id: GO:0035165
name: embryonic crystal cell differentiation
namespace: biological_process
def: "The process in which an embryonic mesoderm-derived hemocyte precursor cell acquires the specialized features of a crystal cell. Crystal cells are a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph." [GOC:bf, http://sdb.bio.purdue.edu/fly/gene/serpent3.htm]
is_a: GO:0035163 ! embryonic hemocyte differentiation
is_a: GO:0042688 ! crystal cell differentiation

[Term]
id: GO:0035166
name: post-embryonic hemopoiesis
namespace: biological_process
def: "The stages of blood cell formation that take place after completion of embryonic development." [GOC:bf]
synonym: "post-embryonic haemopoiesis" EXACT []
is_a: GO:0030097 ! hemopoiesis
is_a: GO:0048569 ! post-embryonic organ development
relationship: part_of GO:0009791 ! post-embryonic development

[Term]
id: GO:0035167
name: larval lymph gland hemopoiesis
namespace: biological_process
def: "The production of blood cells from the larval lymph gland. The lymph gland consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages." [GOC:bf, GOC:mtg_sensu, PMID:12445385]
synonym: "larval lymph gland haematopoiesis" EXACT []
synonym: "larval lymph gland haemopoiesis" EXACT []
synonym: "larval lymph gland hematopoiesis" EXACT []
is_a: GO:0035166 ! post-embryonic hemopoiesis
relationship: part_of GO:0002164 ! larval development
relationship: part_of GO:0048542 ! lymph gland development

[Term]
id: GO:0035168
name: larval lymph gland hemocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell derived from the larval lymph gland acquires the specialized features of a mature hemocyte. The lymph gland consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:14602069]
synonym: "larval lymph gland arthropod blood cell differentiation" EXACT []
is_a: GO:0042386 ! hemocyte differentiation
relationship: part_of GO:0035167 ! larval lymph gland hemopoiesis

[Term]
id: GO:0035169
name: lymph gland plasmatocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized larval lymph gland-derived hemocyte precursor cell acquires the specialized features of the phagocytic blood-cell type, the plasmatocyte." [GOC:bf, PMID:11921077, PMID:8174791]
synonym: "lymph gland plasmatocyte cell differentiation" EXACT []
is_a: GO:0035168 ! larval lymph gland hemocyte differentiation
is_a: GO:0042387 ! plasmatocyte differentiation

[Term]
id: GO:0035170
name: lymph gland crystal cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized larval lymph gland-derived hemocyte precursor cell acquires the specialized features of a crystal cell. Crystal cells are a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph." [GOC:bf, http://sdb.bio.purdue.edu/fly/gene/serpent3.htm]
is_a: GO:0035168 ! larval lymph gland hemocyte differentiation
is_a: GO:0042688 ! crystal cell differentiation

[Term]
id: GO:0035171
name: lamellocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized hemocyte precursor cell acquires the specialized features of a lamellocyte. Lamellocytes are a hemocyte lineage that exists only in larvae, but are seldom observed in healthy animals. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes." [GOC:bf, PMID:14734104]
synonym: "lamellocyte cell differentiation" EXACT []
is_a: GO:0035168 ! larval lymph gland hemocyte differentiation
is_a: GO:0042387 ! plasmatocyte differentiation

[Term]
id: GO:0035172
name: hemocyte proliferation
namespace: biological_process
def: "The multiplication or reproduction of hemocytes, resulting in the expansion of the cell population. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu]
synonym: "arthropod blood cell proliferation" EXACT []
is_a: GO:0002376 ! immune system process
is_a: GO:0008283 ! cell proliferation

[Term]
id: GO:0035173
name: histone kinase activity
namespace: molecular_function
def: "Catalysis of the transfer of a phosphate group to a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes." [GOC:bf]
is_a: GO:0004672 ! protein kinase activity
relationship: part_of GO:0016572 ! histone phosphorylation

[Term]
id: GO:0035174
name: histone serine kinase activity
namespace: molecular_function
def: "Catalysis of the transfer of a phosphate group to a serine residue of a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes." [GOC:bf]
synonym: "histone-serine kinase activity" EXACT []
is_a: GO:0004674 ! protein serine/threonine kinase activity
is_a: GO:0035173 ! histone kinase activity
relationship: part_of GO:0035404 ! histone-serine phosphorylation

[Term]
id: GO:0035175
name: histone kinase activity (H3-S10 specific)
namespace: molecular_function
alt_id: GO:0044021
def: "Catalysis of the transfer of a phosphate group to the serine-10 residue of the N-terminal tail of histone H3." [GOC:bf, PMID:15041176]
synonym: "histone kinase activity (H3-S3 specific)" EXACT []
synonym: "histone serine kinase activity (H3-S10 specific)" EXACT []
synonym: "histone-serine kinase activity (H3-S10 specific)" EXACT []
is_a: GO:0035174 ! histone serine kinase activity
relationship: part_of GO:0043987 ! histone H3-S10 phosphorylation

[Term]
id: GO:0035176
name: social behavior
namespace: biological_process
def: "Behavior directed towards society, or taking place between members of the same species. Occurs predominantly, or only, in individuals that are part of a group." [GOC:jh2, PMID:12848939, Wikipedia:Social_behavior]
comment: Behavior such as predation which involves members of different species is not social. Communication between members of different species is also not social behavior.
synonym: "cooperative behavior" RELATED []
synonym: "social behaviour" EXACT []
xref: Wikipedia:Social_behavior
is_a: GO:0051703 ! intraspecies interaction between organisms
is_a: GO:0051705 ! multi-organism behavior

[Term]
id: GO:0035177
name: larval foraging behavior
namespace: biological_process
def: "The movement of a larva through a feeding substrate whilst feeding on food." [PMID:12848927]
synonym: "larval foraging behaviour" EXACT []
is_a: GO:0030537 ! larval behavior
is_a: GO:0060756 ! foraging behavior

[Term]
id: GO:0035178
name: turning behavior
namespace: biological_process
def: "Fine-tuning the spatial position of an organism in response to variability in their environment. For example, reorientation of an organism in the direction of a food source." [PMID:10880478]
synonym: "turning behaviour" EXACT []
is_a: GO:0007626 ! locomotory behavior

[Term]
id: GO:0035179
name: larval turning behavior
namespace: biological_process
def: "Fine-tuning the spatial position of a larva in response to variability in their environment. For example, reorientation of a larva in the direction of a food source." [PMID:10880478]
synonym: "larval turning behaviour" EXACT []
is_a: GO:0008345 ! larval locomotory behavior
is_a: GO:0035178 ! turning behavior

[Term]
id: GO:0035180
name: larval wandering behavior
namespace: biological_process
def: "The movement of a third instar larva through a substrate in search of a pupation site. This movement occurs without feeding and is characterized by short bursts of forward movement, separated by stops and repeated side-to-side head probes, followed normally by a change in direction." [PMID:12848927, PMID:12956960]
synonym: "larval wandering behaviour" EXACT []
is_a: GO:0008345 ! larval locomotory behavior

[Term]
id: GO:0035181
name: larval burrowing behavior
namespace: biological_process
def: "Digging into the substrate by non-feeding larvae in search for food-free sites suitable for pupation." [PMID:12848927, PMID:12848939]
synonym: "larval burrowing behaviour" EXACT []
is_a: GO:0008345 ! larval locomotory behavior

[Term]
id: GO:0035182
name: female germline ring canal outer rim
namespace: cellular_component
def: "An electron opaque backbone of the insect ovarian ring canal that is a part of or adjacent to the plasma membrane. The outer rim is established as the cleavage furrow is arrested, and contains F-actin, anillin, glycoproteins and at least one a protein with a high content of phosphorylated tyrosine residues." [PMID:12435357, PMID:7925006]
comment: See also the fly_anatomy.ontology term 'outer nurse cell ring canal rim ; FBbt:00004882'.
synonym: "germline ring canal outer rim" BROAD []
synonym: "nurse cell ring canal outer rim" NARROW []
synonym: "ovarian ring canal outer rim" NARROW []
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0035324 ! female germline ring canal

[Term]
id: GO:0035183
name: female germline ring canal inner rim
namespace: cellular_component
def: "A proteinaceous actin-rich layer of the insect ovarian ring canal that forms subcortically to the outer rim. The electron dense inner rim accumulates after the final mitotic division of each germline syncytia, and contains actin, a phosphotyrosine protein, and a number of cytoskeletal proteins." [PMID:10556087, PMID:7925006, PMID:9093858]
comment: See also the fly_anatomy.ontology term 'inner nurse cell ring canal rim ; FBbt:00004881'.
synonym: "germline ring canal inner rim" BROAD []
synonym: "nurse cell ring canal inner rim" NARROW []
synonym: "ovarian ring canal inner rim" NARROW []
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0035324 ! female germline ring canal

[Term]
id: GO:0035184
name: histone threonine kinase activity
namespace: molecular_function
def: "Catalysis of the transfer of a phosphate group to a threonine residue of a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes." [GOC:bf]
synonym: "histone-threonine kinase activity" EXACT []
is_a: GO:0004674 ! protein serine/threonine kinase activity
is_a: GO:0035173 ! histone kinase activity
relationship: part_of GO:0035405 ! histone-threonine phosphorylation

[Term]
id: GO:0035185
name: preblastoderm mitotic cell cycle
namespace: biological_process
def: "The first nine mitotic division cycles of the insect embryo, during which the dividing nuclei lie deep in the interior of the egg and divide nearly synchronously. This is the first phase of the syncytial period where nuclei divide in a common cytoplasm without cytokinesis." [ISBN:0879694238]
is_a: GO:0033301 ! cell cycle comprising mitosis without cytokinesis
is_a: GO:0045448 ! mitotic cell cycle, embryonic

[Term]
id: GO:0035186
name: syncytial blastoderm mitotic cell cycle
namespace: biological_process
def: "Mitotic division cycles 10 to 13 of the insect embryo. This is the second phase of the syncytial period where nuclei divide in a common cytoplasm without cytokinesis. The majority of migrating nuclei reach the embryo surface during cycle 10, after which they divide less synchronously than before, and the syncytial blastoderm cycles lengthen progressively." [ISBN:0879694238]
is_a: GO:0033301 ! cell cycle comprising mitosis without cytokinesis
is_a: GO:0045448 ! mitotic cell cycle, embryonic

[Term]
id: GO:0035187
name: hatching behavior
namespace: biological_process
def: "The specific behavior of an organism during the emergence from an egg shell. In Drosophila for example, the larva swings its head reiteratively through a semicircular arc, using its mouth hooks to tear apart the chorion in front of it and thus free itself from within the egg shell." [GOC:pr, PMID:10436051]
synonym: "hatching behaviour" EXACT []
is_a: GO:0044707 ! single-multicellular organism process
is_a: GO:0044708 ! single-organism behavior
relationship: part_of GO:0035188 ! hatching

[Term]
id: GO:0035188
name: hatching
namespace: biological_process
def: "The emergence of an immature organism from a protective structure." [GOC:dgh, GOC:isa_complete, ISBN:0198612001]
is_a: GO:0071684 ! organism emergence from protective structure
relationship: part_of GO:0007275 ! multicellular organism development

[Term]
id: GO:0035189
name: Rb-E2F complex
namespace: cellular_component
def: "A multiprotein complex containing a heterodimeric E2F transcription factor and a Retinoblastoma (Rb) family member. This complex is capable of repressing transcription of E2F-regulated genes in order to regulate cell cycle progression." [PMID:14616073]
synonym: "retinoblastoma-E2F complex" EXACT []
is_a: GO:0090575 ! RNA polymerase II transcription factor complex

[Term]
id: GO:0035190
name: syncytial nuclear migration
namespace: biological_process
def: "The directed movement of nuclei within the syncytial embryo of insects. These precise temporal and spatial patterns of nuclear movement are coordinated with mitotic divisons and are required during blastoderm formation to reposition dividing nuclei from the interior of the syncytial embryo to the cortex." [GOC:bf, ISBN:0879694238, PMID:8314839]
is_a: GO:0007097 ! nuclear migration
relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm

[Term]
id: GO:0035191
name: nuclear axial expansion
namespace: biological_process
def: "The stepwise asymmetric spreading out of nuclei internally along the anterior-posterior axis of the developing insect embryo during mitotic cycles 4 to 6. This movement leads to the distribution of nuclei in a hollow ellipsoid underlying the cortex." [PMID:8314839]
synonym: "nuclear distribution along anterior-posterior axis" EXACT []
synonym: "nucleus distribution along anterior-posterior axis" EXACT []
is_a: GO:0035190 ! syncytial nuclear migration

[Term]
id: GO:0035192
name: nuclear cortical migration
namespace: biological_process
def: "The symmetric outward movement of the syncytial nuclei from their positions in the ellipsoid toward the periphery of the embryo, during mitotic cycles 8 and 9. This movement results in the placement of nuclei in a uniform monolayer at the cortex of the developing embryo." [PMID:8314839]
is_a: GO:0035190 ! syncytial nuclear migration

[Term]
id: GO:0035193
name: larval central nervous system remodeling
namespace: biological_process
def: "Reorganization of the pre-existing, functional larval central nervous system into one that can serve the novel behavioral needs of the adult. An example of this process is found in Drosophila melanogaster." [GOC:sensu, PMID:9647692]
synonym: "central nervous system metamorphosis" EXACT []
synonym: "CNS metamorphosis" EXACT []
is_a: GO:0009886 ! post-embryonic morphogenesis
relationship: part_of GO:0002165 ! instar larval or pupal development
relationship: part_of GO:0007417 ! central nervous system development

[Term]
id: GO:0035194
name: posttranscriptional gene silencing by RNA
namespace: biological_process
def: "Any process of posttranscriptional gene inactivation (silencing) mediated by small RNA molecules that may trigger mRNA degradation or negatively regulate translation." [GOC:mah, PMID:15020054, PMID:15066275, PMID:15066283]
synonym: "RNA-mediated posttranscriptional gene silencing" EXACT [GOC:dph, GOC:tb]
synonym: "sense-PTGS" RELATED []
is_a: GO:0016441 ! posttranscriptional gene silencing
is_a: GO:0031047 ! gene silencing by RNA

[Term]
id: GO:0035195
name: gene silencing by miRNA
namespace: biological_process
def: "Downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: endolytic cleavage of mRNA cleavage or translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA." [PMID:14744438, PMID:15066275, PMID:15066283, PMID:23209154]
synonym: "gene silencing by microRNA" EXACT [GOC:pr]
synonym: "microRNA-mediated gene silencing" EXACT []
synonym: "miRNA-mediated gene silencing" EXACT [GOC:dph, GOC:tb]
is_a: GO:0017148 ! negative regulation of translation
is_a: GO:0035194 ! posttranscriptional gene silencing by RNA
relationship: negatively_regulates GO:0006412 ! translation

[Term]
id: GO:0035196
name: production of miRNAs involved in gene silencing by miRNA
namespace: biological_process
alt_id: GO:0030918
def: "Cleavage of stem-loop RNA precursors into microRNAs (miRNAs), a class of small RNAs that primarily silence genes by blocking the translation of mRNA transcripts into protein." [GOC:dph, GOC:tb, PMID:15066275, PMID:15066283]
synonym: "gene silencing by miRNA, production of miRNAs" EXACT [GOC:mah]
synonym: "microRNA biogenesis" RELATED [GOC:tb]
synonym: "microRNA biosynthesis" RELATED []
synonym: "microRNA biosynthetic process" RELATED []
synonym: "microRNA metabolic process" RELATED []
synonym: "microRNA metabolism" RELATED []
synonym: "microRNA processing" BROAD []
synonym: "microRNA-mediated gene silencing, production of microRNAs" EXACT []
synonym: "miRNA biogenesis" RELATED [GOC:tb]
synonym: "miRNA processing" EXACT []
synonym: "miRNA-mediated gene silencing, production of miRNAs" EXACT [GOC:dph, GOC:tb]
synonym: "production of microRNAs involved in gene silencing by microRNA" EXACT [GOC:pr]
is_a: GO:0070918 ! production of small RNA involved in gene silencing by RNA
relationship: part_of GO:0035195 ! gene silencing by miRNA

[Term]
id: GO:0035197
name: siRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme." [PMID:15066275, PMID:15066283]
synonym: "small interfering RNA binding" EXACT []
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0035198
name: miRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes." [PMID:15066283]
synonym: "microRNA binding" EXACT []
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0035199
name: salt aversion
namespace: biological_process
def: "The specific avoidance actions or reactions of an organism in response to the perception of salt." [GOC:bf]
synonym: "behavioral response to salt" BROAD []
is_a: GO:0007631 ! feeding behavior
relationship: part_of GO:0042221 ! response to chemical

[Term]
id: GO:0035200
name: leg disc anterior/posterior pattern formation
namespace: biological_process
def: "The establishment, maintenance and elaboration of the anterior/posterior axis of the leg imaginal disc." [GOC:bf]
is_a: GO:0007448 ! anterior/posterior pattern specification, imaginal disc
is_a: GO:0035223 ! leg disc pattern formation

[Term]
id: GO:0035201
name: leg disc anterior/posterior lineage restriction
namespace: biological_process
def: "Formation and/or maintenance of a lineage boundary between anterior and posterior compartments of the leg disc that cells cannot cross, thus separating the populations of cells in each compartment." [GOC:bf]
is_a: GO:0048099 ! anterior/posterior lineage restriction, imaginal disc
relationship: part_of GO:0035200 ! leg disc anterior/posterior pattern formation

[Term]
id: GO:0035202
name: tracheal pit formation in open tracheal system
namespace: biological_process
def: "Formation of the tracheal pits, the first tube-like structures to form in the open tracheal system. Once cells are determined to their tracheal cell fate, the tracheal pits arise by invagination of each ectodermal cluster of tracheal placode cells, between 5 and 7 hours after egg laying. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11063940, PMID:11992723, PMID:14570584]
synonym: "tracheal placode invagination" RELATED []
synonym: "tracheal sac formation" BROAD []
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0007424 ! open tracheal system development

[Term]
id: GO:0035203
name: regulation of lamellocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lamellocyte differentiation. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes." [PMID:14734104]
is_a: GO:0045613 ! regulation of plasmatocyte differentiation
is_a: GO:0048580 ! regulation of post-embryonic development
is_a: GO:1903706 ! regulation of hemopoiesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035171 ! lamellocyte differentiation
relationship: regulates GO:0035171 ! lamellocyte differentiation

[Term]
id: GO:0035204
name: negative regulation of lamellocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lamellocyte differentiation. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes." [PMID:14734104]
synonym: "down regulation of lamellocyte differentiation" EXACT []
synonym: "down-regulation of lamellocyte differentiation" EXACT []
synonym: "downregulation of lamellocyte differentiation" EXACT []
synonym: "inhibition of lamellocyte differentiation" NARROW []
is_a: GO:0035203 ! regulation of lamellocyte differentiation
is_a: GO:0045614 ! negative regulation of plasmatocyte differentiation
is_a: GO:0048581 ! negative regulation of post-embryonic development
is_a: GO:1903707 ! negative regulation of hemopoiesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035171 ! lamellocyte differentiation
relationship: negatively_regulates GO:0035171 ! lamellocyte differentiation

[Term]
id: GO:0035205
name: positive regulation of lamellocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lamellocyte differentiation. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes." [PMID:14734104]
synonym: "activation of lamellocyte differentiation" NARROW []
synonym: "stimulation of lamellocyte differentiation" NARROW []
synonym: "up regulation of lamellocyte differentiation" EXACT []
synonym: "up-regulation of lamellocyte differentiation" EXACT []
synonym: "upregulation of lamellocyte differentiation" EXACT []
is_a: GO:0035203 ! regulation of lamellocyte differentiation
is_a: GO:0045615 ! positive regulation of plasmatocyte differentiation
is_a: GO:0048582 ! positive regulation of post-embryonic development
is_a: GO:1903708 ! positive regulation of hemopoiesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035171 ! lamellocyte differentiation
relationship: positively_regulates GO:0035171 ! lamellocyte differentiation

[Term]
id: GO:0035206
name: regulation of hemocyte proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
synonym: "regulation of arthropod blood cell proliferation" EXACT []
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0042127 ! regulation of cell proliferation
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035172 ! hemocyte proliferation
relationship: regulates GO:0035172 ! hemocyte proliferation

[Term]
id: GO:0035207
name: negative regulation of hemocyte proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
synonym: "down regulation of hemocyte proliferation" EXACT []
synonym: "down-regulation of hemocyte proliferation" EXACT []
synonym: "downregulation of hemocyte proliferation" EXACT []
synonym: "inhibition of hemocyte proliferation" NARROW []
synonym: "negative regulation of arthropod blood cell proliferation" EXACT []
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0008285 ! negative regulation of cell proliferation
is_a: GO:0035206 ! regulation of hemocyte proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035172 ! hemocyte proliferation
relationship: negatively_regulates GO:0035172 ! hemocyte proliferation

[Term]
id: GO:0035208
name: positive regulation of hemocyte proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) that are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
synonym: "activation of hemocyte proliferation" NARROW []
synonym: "positive regulation of arthropod blood cell proliferation" EXACT []
synonym: "stimulation of hemocyte proliferation" NARROW []
synonym: "up regulation of hemocyte proliferation" EXACT []
synonym: "up-regulation of hemocyte proliferation" EXACT []
synonym: "upregulation of hemocyte proliferation" EXACT []
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0008284 ! positive regulation of cell proliferation
is_a: GO:0035206 ! regulation of hemocyte proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035172 ! hemocyte proliferation
relationship: positively_regulates GO:0035172 ! hemocyte proliferation

[Term]
id: GO:0035209
name: pupal development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pupa over time, from its formation to the mature structure. The pupa is a dormant life stage interposed between the larval and the adult stages in insects that undergo a complete metamorphosis." [GOC:bf, GOC:mtg_sensu]
is_a: GO:0002165 ! instar larval or pupal development

[Term]
id: GO:0035210
name: prepupal development
namespace: biological_process
def: "The process whose specific outcome is the progression of the prepupa over time, from its formation to the mature structure. The prepupal stage is a life stage interposed between the larval and the pupal stages in insects that undergo a complete metamorphosis. The start of the pre-pupal stage is marked by pupariation, and the end is marked by pupation." [GOC:mtg_sensu, http://sdb.bio.purdue.edu/fly/aimain/1adult.htm]
comment: See also the fly_anatomy.ontology term 'prepupa ; FBbt:00002952'.
is_a: GO:0002165 ! instar larval or pupal development

[Term]
id: GO:0035211
name: spermathecum morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a spermathecum, a sperm storage organ, are generated and organized. Paired spermathecae lie at the anterior end of the insect uterus on the dorsal side. Each spermatheca consists of an oval shaped capsule, connected to the uterus by a spermathecal stalk." [PMID:12679097]
comment: See also the fly_anatomy.ontology term 'spermathecum ; FBbt:00004921'.
is_a: GO:0009887 ! organ morphogenesis

[Term]
id: GO:0035212
name: cell competition in a multicellular organism
namespace: biological_process
def: "Competitive interactions within multicellular organisms between cell populations that differ in growth rates, leading to the elimination of the slowest-growing cells." [GOC:bf, PMID:1116643, PMID:15066286]
is_a: GO:0040008 ! regulation of growth
is_a: GO:0044763 ! single-organism cellular process
relationship: part_of GO:0007275 ! multicellular organism development

[Term]
id: GO:0035213
name: clypeo-labral disc development
namespace: biological_process
def: "The process whose specific outcome is the progression of the clypeo-labral disc over time, from its formation to the metamorphosis to form adult structures. The clypeo-labral disc develops into the labrum, anterior cibarial plate, fish trap bristles, epistomal sclerite." [GOC:bf, ISBN:0879694238]
synonym: "development of structures derived from the clypeo-labral disc" EXACT []
is_a: GO:0007444 ! imaginal disc development

[Term]
id: GO:0035214
name: eye-antennal disc development
namespace: biological_process
def: "Progression of the eye-antennal imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238]
is_a: GO:0007444 ! imaginal disc development

[Term]
id: GO:0035215
name: genital disc development
namespace: biological_process
def: "Progression of the genital imaginal disc over time, from its initial formation through to its metamorphosis to form the adult terminalia, comprising the entire set of internal and external genitalia and analia. Both sexes of Drosophila have a single genital disc formed from the female and male genital primordia, and the anal primordium. The anal primordium develops in both sexes, forming either male or female analia. However, only one of the genital primordia develops in each sex, forming either the male or the female genitalia." [GOC:bf, ISBN:0879694238, PMID:11494318]
is_a: GO:0007444 ! imaginal disc development

[Term]
id: GO:0035216
name: haltere disc development
namespace: biological_process
def: "Progression of the haltere imaginal disc over time, from its initial formation through to its metamorphosis to form the adult capitellum, pedicel, haltere sclerite, metathoracic spiracle and metanotum." [GOC:bf, ISBN:0879694238]
is_a: GO:0007444 ! imaginal disc development

[Term]
id: GO:0035217
name: labial disc development
namespace: biological_process
def: "Progression of the labial imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including parts of the proboscis." [GOC:bf, ISBN:0879694238]
is_a: GO:0007444 ! imaginal disc development

[Term]
id: GO:0035218
name: leg disc development
namespace: biological_process
def: "Progression of the leg imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including the leg, coxa and ventral thoracic pleura." [GOC:bf, ISBN:0879694238]
is_a: GO:0007444 ! imaginal disc development

[Term]
id: GO:0035219
name: prothoracic disc development
namespace: biological_process
def: "Progression of the prothoracic disc over time, from its initial formation through to its metamorphosis to form the adult humerous and anterior spiracle." [GOC:bf, ISBN:0879694238]
is_a: GO:0007444 ! imaginal disc development

[Term]
id: GO:0035220
name: wing disc development
namespace: biological_process
def: "Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
is_a: GO:0007444 ! imaginal disc development

[Term]
id: GO:0035221
name: genital disc pattern formation
namespace: biological_process
def: "The process that gives rise to the patterns of cell differentiation that will arise in the genital imaginal disc." [GOC:bf]
is_a: GO:0007447 ! imaginal disc pattern formation
relationship: part_of GO:0035215 ! genital disc development

[Term]
id: GO:0035222
name: wing disc pattern formation
namespace: biological_process
def: "The process giving rise to the pattern of cell differentiation in the wing imaginal disc." [GOC:bf]
is_a: GO:0007447 ! imaginal disc pattern formation
relationship: part_of GO:0035220 ! wing disc development

[Term]
id: GO:0035223
name: leg disc pattern formation
namespace: biological_process
def: "The process that gives rise to the patterns of cell differentiation in the leg imaginal disc." [GOC:bf]
is_a: GO:0007447 ! imaginal disc pattern formation
relationship: part_of GO:0035218 ! leg disc development

[Term]
id: GO:0035224
name: genital disc anterior/posterior pattern formation
namespace: biological_process
def: "The establishment, maintenance and elaboration of the anterior/posterior axis of the genital disc. An anterior and posterior compartment form in each of the three genital disc primoridia (the female genital disc primordium, the male genital disc primordium and the anal primordium)." [PMID:11494318]
is_a: GO:0007448 ! anterior/posterior pattern specification, imaginal disc
is_a: GO:0035221 ! genital disc pattern formation

[Term]
id: GO:0035225
name: determination of genital disc primordium
namespace: biological_process
def: "Allocation of embryonic cells to the genital imaginal disc founder populations. Early in development at the blastoderm stage, the anlage of the genital disc of both sexes consists of three primordia: the female genital primoridum lcoated anteriorly, the anal primoridum located posteriorly, and the male gential primordium between the two." [GOC:bf, PMID:11494318]
is_a: GO:0007445 ! determination of imaginal disc primordium
relationship: part_of GO:0035215 ! genital disc development

[Term]
id: GO:0035226
name: glutamate-cysteine ligase catalytic subunit binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the catalytic subunit of glutamate-cysteine ligase." [PMID:12954617]
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0035227
name: regulation of glutamate-cysteine ligase activity
namespace: biological_process
def: "Any process that modulates the activity of glutamate-cysteine ligase." [GOC:bf]
subset: gosubset_prok
is_a: GO:0051340 ! regulation of ligase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004357 ! glutamate-cysteine ligase activity
relationship: regulates GO:0004357 ! glutamate-cysteine ligase activity

[Term]
id: GO:0035228
name: negative regulation of glutamate-cysteine ligase activity
namespace: biological_process
def: "Any process that stops or reduces the activity of the enzyme glutamate-cysteine ligase." [GOC:bf]
subset: gosubset_prok
synonym: "down regulation of glutamate-cysteine ligase activity" EXACT []
synonym: "down-regulation of glutamate-cysteine ligase activity" EXACT []
synonym: "downregulation of glutamate-cysteine ligase activity" EXACT []
synonym: "inhibition of glutamate-cysteine ligase activity" NARROW []
is_a: GO:0035227 ! regulation of glutamate-cysteine ligase activity
is_a: GO:0051352 ! negative regulation of ligase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004357 ! glutamate-cysteine ligase activity
relationship: negatively_regulates GO:0004357 ! glutamate-cysteine ligase activity

[Term]
id: GO:0035229
name: positive regulation of glutamate-cysteine ligase activity
namespace: biological_process
def: "Any process that activates or increases the activity of glutamate-cysteine ligase, typically by lowering its sensitivity to inhibition by glutathione and by increasing its affinity for glutamate." [PMID:12954617]
subset: gosubset_prok
synonym: "activation of glutamate-cysteine ligase activity" NARROW []
synonym: "stimulation of glutamate-cysteine ligase activity" NARROW []
synonym: "up regulation of glutamate-cysteine ligase activity" EXACT []
synonym: "up-regulation of glutamate-cysteine ligase activity" EXACT []
synonym: "upregulation of glutamate-cysteine ligase activity" EXACT []
is_a: GO:0035227 ! regulation of glutamate-cysteine ligase activity
is_a: GO:0051351 ! positive regulation of ligase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004357 ! glutamate-cysteine ligase activity
relationship: positively_regulates GO:0004357 ! glutamate-cysteine ligase activity

[Term]
id: GO:0035230
name: cytoneme
namespace: cellular_component
def: "A long, thin, polarized cell projection that contains actin and can extend for distances many times the diameter of the cell. Cytonemes represent extensions of cell cytoplasm and typically have a diameter of approximately 0.2um." [PMID:10367889, PMID:10675901]
subset: goslim_pir
synonym: "membrane nanotube" EXACT [Wikipedia:Membrane_nanotube]
xref: Wikipedia:Membrane_nanotube
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0035231
name: cytoneme assembly
namespace: biological_process
def: "Formation of a cytoneme, a long, thin and polarized actin-based cytoplasmic extension that projects from a cell." [PMID:10367889, PMID:10675901]
synonym: "cytoneme biogenesis" RELATED [GOC:mah]
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
is_a: GO:0030031 ! cell projection assembly
relationship: part_of GO:0003399 ! cytoneme morphogenesis

[Term]
id: GO:0035232
name: germ cell attraction
namespace: biological_process
def: "The directed movement of a germ cell from their site of production to the gonad, through the attraction of cells towards their target." [PMID:12885551]
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0050918 ! positive chemotaxis
is_a: GO:0060326 ! cell chemotaxis
relationship: part_of GO:0008354 ! germ cell migration

[Term]
id: GO:0035233
name: germ cell repulsion
namespace: biological_process
def: "The directed movement of a germ cell from their site of production to the gonad, through the repulsion of cells away from a tissue." [PMID:12885551]
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0050919 ! negative chemotaxis
is_a: GO:0060326 ! cell chemotaxis
relationship: part_of GO:0008354 ! germ cell migration

[Term]
id: GO:0035234
name: ectopic germ cell programmed cell death
namespace: biological_process
def: "Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo." [PMID:12814944]
synonym: "programmed cell death of ectopic germ cells" EXACT []
synonym: "programmed cell death, ectopic germ cells" EXACT []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0010623 ! developmental programmed cell death
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism

[Term]
id: GO:0035235
name: ionotropic glutamate receptor signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:0198506732]
synonym: "ionotropic glutamate receptor signalling pathway" EXACT []
is_a: GO:0007215 ! glutamate receptor signaling pathway

[Term]
id: GO:0035236
name: proctolin receptor activity
namespace: molecular_function
def: "Combining with the neuropeptide proctolin, to initiate a change in cell activity." [GOC:bf]
is_a: GO:0008188 ! neuropeptide receptor activity

[Term]
id: GO:0035237
name: corazonin receptor activity
namespace: molecular_function
def: "Combining with the neuropeptide corazonin to initiate a change in cell activity." [GOC:bf]
is_a: GO:0008188 ! neuropeptide receptor activity

[Term]
id: GO:0035238
name: vitamin A biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid. Animals cannot synthesize vitamin A de novo, but form it through oxidative cleavage of carotenoids." [PMID:11158606]
subset: gosubset_prok
synonym: "vitamin A anabolism" EXACT []
synonym: "vitamin A biosynthesis" EXACT []
synonym: "vitamin A formation" EXACT []
synonym: "vitamin A synthesis" EXACT []
is_a: GO:0006776 ! vitamin A metabolic process
is_a: GO:0016102 ! diterpenoid biosynthetic process
is_a: GO:0042362 ! fat-soluble vitamin biosynthetic process

[Term]
id: GO:0035239
name: tube morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GOC:bf, PMID:14624839]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0035295 ! tube development

[Term]
id: GO:0035240
name: dopamine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with dopamine, a catecholamine neurotransmitter formed by aromatic-L-amino-acid decarboxylase from 3,4-dihydroxy-L-phenylalanine." [ISBN:0198506732]
is_a: GO:0070405 ! ammonium ion binding
is_a: GO:1901338 ! catecholamine binding

[Term]
id: GO:0035241
name: protein-arginine omega-N monomethyltransferase activity
namespace: molecular_function
def: "Catalysis of the addition of a methyl group to either of the unmethylated terminal nitrogen atoms (also called omega nitrogen) in peptidyl-arginine to form an omega-N-G-monomethylated arginine residue." [PMID:14705965, RESID:AA0069]
xref: RESID:AA0069
is_a: GO:0016274 ! protein-arginine N-methyltransferase activity
relationship: part_of GO:0035247 ! peptidyl-arginine omega-N-methylation

[Term]
id: GO:0035242
name: protein-arginine omega-N asymmetric methyltransferase activity
namespace: molecular_function
def: "Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the same terminal nitrogen (omega nitrogen) residue that was previously methylated, resulting in asymmetrical peptidyl-N(omega),N(omega)-dimethylated arginine residues." [PMID:14705965, RESID:AA0068, RESID:AA0069]
comment: Note that type I protein arginine N-methyltransferase enzymes possess 'protein-arginine omega-N monomethyltransferase activity ; GO:0035241' and 'protein-arginine omega-N asymmetric methyltransferase activity ; GO:0035242'.
synonym: "type I PRMT activity" RELATED []
synonym: "type I protein arginine methyltransferase activity" RELATED []
xref: RESID:AA0068
xref: RESID:AA0069
is_a: GO:0016274 ! protein-arginine N-methyltransferase activity
relationship: part_of GO:0019919 ! peptidyl-arginine methylation, to asymmetrical-dimethyl arginine

[Term]
id: GO:0035243
name: protein-arginine omega-N symmetric methyltransferase activity
namespace: molecular_function
def: "Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the terminal nitrogen (omega nitrogen) residue that is not already methylated, resulting in symmetrical peptidyl-N(omega),N'(omega)-dimethyled arginine residues." [PMID:14705965, RESID:AA0067, RESID:AA0069]
comment: Note that type II protein arginine N-methyltransferase enzymes possess 'protein-arginine omega-N monomethyltransferase activity ; GO:0035241' and 'protein-arginine omega-N symmetric methyltransferase activity ; GO:0035243'.
synonym: "type II PRMT activity" RELATED []
synonym: "type II protein arginine methyltransferase activity" RELATED []
xref: RESID:AA0067
xref: RESID:AA0069
is_a: GO:0016274 ! protein-arginine N-methyltransferase activity
relationship: part_of GO:0019918 ! peptidyl-arginine methylation, to symmetrical-dimethyl arginine

[Term]
id: GO:0035244
name: peptidyl-arginine C-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group to the carbon atom of an arginine residue in a protein." [GOC:bf]
is_a: GO:0008169 ! C-methyltransferase activity
is_a: GO:0008276 ! protein methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
relationship: part_of GO:0035245 ! peptidyl-arginine C-methylation

[Term]
id: GO:0035245
name: peptidyl-arginine C-methylation
namespace: biological_process
def: "The addition of a methyl group onto a carbon atom of an arginine residue in a protein." [GOC:bf]
subset: gosubset_prok
is_a: GO:0018216 ! peptidyl-arginine methylation

[Term]
id: GO:0035246
name: peptidyl-arginine N-methylation
namespace: biological_process
def: "The addition of a methyl group onto a nitrogen atom of an arginine residue in a protein." [GOC:bf]
subset: gosubset_prok
is_a: GO:0018216 ! peptidyl-arginine methylation

[Term]
id: GO:0035247
name: peptidyl-arginine omega-N-methylation
namespace: biological_process
def: "The addition of a methyl group onto a terminal nitrogen (omega nitrogen) atom of an arginine residue in a protein." [PMID:14705965, RESID:AA0067, RESID:AA0068, RESID:AA0069]
subset: gosubset_prok
xref: RESID:AA0067
xref: RESID:AA0068
xref: RESID:AA0069
is_a: GO:0035246 ! peptidyl-arginine N-methylation

[Term]
id: GO:0035248
name: alpha-1,4-N-acetylgalactosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an acceptor molecule, forming an alpha-1,4 linkage." [PMID:15130086]
synonym: "alpha-1,4-GalNAc transferase activity" EXACT []
is_a: GO:0008376 ! acetylgalactosaminyltransferase activity

[Term]
id: GO:0035249
name: synaptic transmission, glutamatergic
namespace: biological_process
def: "The process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:kmv]
is_a: GO:0007270 ! neuron-neuron synaptic transmission

[Term]
id: GO:0035250
name: UDP-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule." [http://www.chem.qmul.ac.uk/iubmb/enzyme/reaction/polysacc/UDPsugar.html]
subset: gosubset_prok
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0008378 ! galactosyltransferase activity

[Term]
id: GO:0035251
name: UDP-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a glucosyl group from UDP-glucose to an acceptor molecule." [http://www.chem.qmul.ac.uk/iubmb/enzyme/reaction/polysacc/UDPsugar.html]
subset: gosubset_prok
xref: MetaCyc:PHENOL-BETA-GLUCOSYLTRANSFERASE-RXN
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0035252
name: UDP-xylosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a xylosyl group from UDP-xylose to an acceptor molecule." [http://www.chem.qmul.ac.uk/iubmb/enzyme/reaction/polysacc/UDPsugar.html]
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0042285 ! xylosyltransferase activity

[Term]
id: GO:0035253
name: ciliary rootlet
namespace: cellular_component
def: "A cytoskeleton-like structure, originating from the basal body at the proximal end of a cilium, and extending proximally toward the cell nucleus. Rootlets are typically 80-100 nm in diameter and contain cross striae distributed at regular intervals of approximately 55-70 nm." [GOC:cilia, PMID:12427867]
synonym: "cilial rootlet" EXACT []
synonym: "cilium rootlet" EXACT []
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044441 ! ciliary part

[Term]
id: GO:0035254
name: glutamate receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a glutamate receptor." [GOC:bf]
subset: goslim_chembl
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0035255
name: ionotropic glutamate receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels." [GOC:bf, ISBN:0198506732]
is_a: GO:0035254 ! glutamate receptor binding

[Term]
id: GO:0035256
name: G-protein coupled glutamate receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a G-protein coupled glutamate receptor (a metabotropic glutamate receptor)." [GOC:bf, ISBN:0198506732, PMID:9069287]
synonym: "metabotropic glutamate receptor binding" EXACT [GOC:bf]
is_a: GO:0001664 ! G-protein coupled receptor binding
is_a: GO:0035254 ! glutamate receptor binding

[Term]
id: GO:0035257
name: nuclear hormone receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a nuclear hormone receptor, a ligand-dependent receptor found in the nucleus of the cell." [GOC:bf]
is_a: GO:0051427 ! hormone receptor binding

[Term]
id: GO:0035258
name: steroid hormone receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a steroid hormone receptor." [GOC:bf]
is_a: GO:0035257 ! nuclear hormone receptor binding

[Term]
id: GO:0035259
name: glucocorticoid receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a glucocorticoid receptor." [GOC:bf]
is_a: GO:0035258 ! steroid hormone receptor binding

[Term]
id: GO:0035260
name: internal genitalia morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the internal genitalia are generated and organized. The internal genitalia are the internal sex organs such as the uterine tube, the uterus and the vagina in female mammals, and the testis, seminal vesicle, ejaculatory duct and prostate in male mammals." [http://www.ndif.org/Terms/genitalia.html]
is_a: GO:0035112 ! genitalia morphogenesis

[Term]
id: GO:0035261
name: external genitalia morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the external genitalia are generated and organized. The external genitalia are the outer sex organs, such as the penis or vulva in mammals." [http://www.ndif.org/Terms/genitalia.html]
is_a: GO:0035112 ! genitalia morphogenesis

[Term]
id: GO:0035262
name: gonad morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the gonads are generated and organized. A gonad is an animal organ producing gametes, e.g. the testes or the ovary in mammals." [ISBN:0198612001]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0009887 ! organ morphogenesis
is_a: GO:0044702 ! single organism reproductive process
relationship: part_of GO:0008406 ! gonad development

[Term]
id: GO:0035263
name: genital disc sexually dimorphic development
namespace: biological_process
def: "The sex-specific patterns of primoridia growth and differentiation in the genital imaginal disc. The anal primordium of the genital disc develops in both sexes, but depending on the genetic sex gives rise to either male or female analia. Depending on the genetic sex, only one of the two genital primordia develop. In females the female genital primordium develops and gives rise to the female genitalia whereas the male primordium is repressed. Conversely, in males the male genital primordium develops and gives rise to the male genitalia whereas the female genital primordium is repressed." [PMID:11290302, PMID:11494318, PMID:11702781]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048609 ! multicellular organismal reproductive process
relationship: part_of GO:0007548 ! sex differentiation
relationship: part_of GO:0035215 ! genital disc development

[Term]
id: GO:0035264
name: multicellular organism growth
namespace: biological_process
def: "The increase in size or mass of an entire multicellular organism, as opposed to cell growth." [GOC:bf, GOC:curators, GOC:dph, GOC:tb]
synonym: "body growth" RELATED []
is_a: GO:0044707 ! single-multicellular organism process
is_a: GO:0048589 ! developmental growth

[Term]
id: GO:0035265
name: organ growth
namespace: biological_process
def: "The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function." [GOC:bf, ISBN:0471245208, ISBN:0721662544]
is_a: GO:0044707 ! single-multicellular organism process
is_a: GO:0048589 ! developmental growth

[Term]
id: GO:0035266
name: meristem growth
namespace: biological_process
def: "The increase in size or mass of a meristem, a region of tissue in a plant that is composed of one or more undifferentiated cells capable of undergoing mitosis and differentiation." [GOC:bf, ISBN:0198547684]
is_a: GO:0048589 ! developmental growth
relationship: part_of GO:0048507 ! meristem development

[Term]
id: GO:0035267
name: NuA4 histone acetyltransferase complex
namespace: cellular_component
def: "A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60)." [GOC:ecd, PMID:10966108, PMID:14966270]
synonym: "TIP60 histone acetylase complex" EXACT []
synonym: "TIP60 histone acetyltransferase complex" EXACT []
is_a: GO:0043189 ! H4/H2A histone acetyltransferase complex

[Term]
id: GO:0035268
name: protein mannosylation
namespace: biological_process
def: "The addition of a mannose residue to a protein acceptor molecule." [GOC:bf, GOC:pr]
subset: gosubset_prok
synonym: "protein amino acid mannosylation" EXACT [GOC:bf]
is_a: GO:0006486 ! protein glycosylation
is_a: GO:0097502 ! mannosylation

[Term]
id: GO:0035269
name: protein O-linked mannosylation
namespace: biological_process
def: "The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage." [GOC:bf, PMID:9878797]
subset: gosubset_prok
synonym: "protein amino acid O-linked mannosylation" EXACT [GOC:bf]
is_a: GO:0006493 ! protein O-linked glycosylation
is_a: GO:0035268 ! protein mannosylation

[Term]
id: GO:0035270
name: endocrine system development
namespace: biological_process
def: "Progression of the endocrine system over time, from its formation to a mature structure. The endocrine system is a system of hormones and ductless glands, where the glands release hormones directly into the blood, lymph or other intercellular fluid, and the hormones circulate within the body to affect distant organs. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathryoids, adrenals, pineal body, and the reproductive glands which include the ovaries and testes." [GOC:bf, http://encyclopedia.thefreedictionary.com/Endocrine+sytem, ISBN:0198506732]
is_a: GO:0048731 ! system development

[Term]
id: GO:0035271
name: ring gland development
namespace: biological_process
def: "Progression of the ring gland over time, from its formation to a mature structure. The ring gland is a neuroendocrine organ found in higher Dipterans, which is composed of the prothoracic gland, the corpus allatum, and the corpora cardiacum. The ring gland is the site of production and release of ecdysteroids and juvenile hormones." [GOC:bf, PMID:11223816, PMID:9584098]
comment: See also the fly_anatomy.ontology terms 'ring gland ; FBbt:00001722, 'prothoracic gland ; FBbt:00001724', 'corpus allatum ; FBbt:00005800' and 'corpus cardiacum ; FBbt:00005799.
is_a: GO:0048732 ! gland development
relationship: part_of GO:0035270 ! endocrine system development

[Term]
id: GO:0035272
name: exocrine system development
namespace: biological_process
def: "Progression of the exocrine system over time, from its formation to a mature structure. The exocrine system is a system of hormones and glands, where the glands secrete straight to a target site via ducts or tubes. The human exocrine system includes the salivary glands, sweat glands and many glands of the digestive system." [GOC:bf, http://encyclopedia.thefreedictionary.com/Exocrine+gland, ISBN:0198506732]
is_a: GO:0048731 ! system development

[Term]
id: GO:0035273
name: phthalate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a phthalate, any ester or salt of phthalic acid." [http://umbbd.ahc.umn.edu/pth/pth_map.html]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0031406 ! carboxylic acid binding
is_a: GO:0097159 ! organic cyclic compound binding

[Term]
id: GO:0035274
name: diphenyl phthalate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with diphenyl phthalate, C(20)H(14)O(4)." [http://www.sigmaaldrich.com]
synonym: "DPP binding" EXACT []
is_a: GO:0097159 ! organic cyclic compound binding

[Term]
id: GO:0035275
name: dibutyl phthalate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with dibutyl phthalate, C(16)H(22)O(4)." [http://www.sigmaaldrich.com]
synonym: "DBP binding" EXACT []
synonym: "phthalic acid dibutyl ester binding" EXACT []
is_a: GO:0097159 ! organic cyclic compound binding

[Term]
id: GO:0035276
name: ethanol binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with ethanol, CH(3)-CH(2)-OH." [ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0043168 ! anion binding
is_a: GO:0043178 ! alcohol binding

[Term]
id: GO:0035277
name: spiracle morphogenesis, open tracheal system
namespace: biological_process
def: "The process in which the anatomical structures of a spiracle are generated and organized. Spiracles are the openings in the insect open tracheal system; externally they connect to the epidermis and internally they connect to the tracheal trunk." [GOC:mtg_sensu, PMID:10491268]
synonym: "spiracle morphogenesis" EXACT []
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0007424 ! open tracheal system development

[Term]
id: GO:0035278
name: miRNA mediated inhibition of translation
namespace: biological_process
def: "The process in which microRNAs (miRNAs) block the translation of target mRNAs into proteins. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA will typically mediate repression of translation if the miRNA imperfectly base-pairs with the 3' untranslated regions of target mRNAs" [PMID:14744438, PMID:15196554]
synonym: "down regulation of translation involved in gene silencing by miRNA" EXACT [GOC:mah]
synonym: "down-regulation of translation involved in gene silencing by miRNA" EXACT [GOC:mah]
synonym: "downregulation of translation involved in gene silencing by miRNA" EXACT [GOC:mah]
synonym: "gene silencing by miRNA, negative regulation of translation" EXACT [GOC:mah]
synonym: "inhibition of translation involved in gene silencing by miRNA" NARROW [GOC:mah]
synonym: "miRNA-mediated gene silencing, negative regulation of translation" RELATED [GOC:dph, GOC:tb]
synonym: "negative regulation of translation involved in gene silencing by microRNA" EXACT [GOC:pr]
is_a: GO:0040033 ! negative regulation of translation, ncRNA-mediated
relationship: part_of GO:0035195 ! gene silencing by miRNA

[Term]
id: GO:0035279
name: mRNA cleavage involved in gene silencing by miRNA
namespace: biological_process
def: "The process in which microRNAs (miRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA base pairing with near-perfect complementarity to the target mRNA will typically direct targeted endonucleolytic cleavage of the mRNA. Many plant miRNAs downregulate gene expression through this mechanism." [GOC:dph, GOC:mtg_lung, PMID:14744438, PMID:15196554]
synonym: "gene silencing by miRNA, mRNA cleavage" EXACT [GOC:mah]
synonym: "miRNA-mediated gene silencing, mRNA cleavage" EXACT [GOC:dph, GOC:tb]
synonym: "mRNA cleavage involved in gene silencing by microRNA" EXACT [GOC:pr]
is_a: GO:0098795 ! mRNA cleavage involved in gene silencing
intersection_of: GO:0006379 ! mRNA cleavage
intersection_of: part_of GO:0035195 ! gene silencing by miRNA
relationship: part_of GO:0035195 ! gene silencing by miRNA

[Term]
id: GO:0035280
name: miRNA loading onto RISC involved in gene silencing by miRNA
namespace: biological_process
def: "The transfer of a microRNA (miRNA) strand from a miRNA:miRNA duplex onto the RNA-initiated silencing complex (RISC)." [PMID:14744438]
synonym: "gene silencing by miRNA, miRNA loading onto RISC" EXACT [GOC:mah]
synonym: "microRNA loading onto RISC involved in gene silencing by microRNA" EXACT [GOC:pr]
synonym: "miRISC assembly" BROAD []
synonym: "miRNA-mediated gene silencing, miRNA loading onto RISC" EXACT [GOC:dph, GOC:tb]
is_a: GO:0070922 ! small RNA loading onto RISC
relationship: part_of GO:0035195 ! gene silencing by miRNA

[Term]
id: GO:0035281
name: pre-miRNA export from nucleus
namespace: biological_process
def: "Transport of pre-microRNAs (pre-miRNAs) from the nucleus to the cytoplasm. Pre-miRNAs are a ~60-70 nucleotide stem loop intermediate in miRNA production, produced by the nuclear cleavage of a primary miRNA (pri-mRNA) transcript. Pre-miRNAs are transported from the nucleus to the cytoplasm where further cleavage occurs to produce a mature miRNA product." [GOC:sl, PMID:14744438]
synonym: "pre-microRNA export from cell nucleus" EXACT []
synonym: "pre-microRNA export from nucleus" RELATED []
synonym: "pre-microRNA export out of nucleus" EXACT []
synonym: "pre-microRNA transport from nucleus to cytoplasm" EXACT []
synonym: "pre-microRNA-nucleus export" EXACT []
is_a: GO:0006405 ! RNA export from nucleus
is_a: GO:1902582 ! single-organism intracellular transport
relationship: part_of GO:0035195 ! gene silencing by miRNA

[Term]
id: GO:0035282
name: segmentation
namespace: biological_process
def: "The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis." [PMID:10611687, PMID:9706689]
xref: Wikipedia:Segmentation_(biology)
is_a: GO:0003002 ! regionalization

[Term]
id: GO:0035283
name: central nervous system segmentation
namespace: biological_process
def: "Division of the central nervous system into a series of semi-repetitive parts or segments." [GOC:bf]
is_a: GO:0035282 ! segmentation
relationship: part_of GO:0007417 ! central nervous system development

[Term]
id: GO:0035284
name: brain segmentation
namespace: biological_process
def: "Division of the brain into a series of semi-repetitive parts or segments." [GOC:bf]
is_a: GO:0035282 ! segmentation
relationship: part_of GO:0007420 ! brain development
relationship: part_of GO:0035283 ! central nervous system segmentation

[Term]
id: GO:0035285
name: appendage segmentation
namespace: biological_process
def: "Division of an appendage, an organ or part that is attached to the main body of an organism, into a series of semi-repetitive parts or segments. Most arthropod appendages, such as the legs and antennae, are visibly segmented." [PMID:10357895]
is_a: GO:0035282 ! segmentation
relationship: part_of GO:0035107 ! appendage morphogenesis

[Term]
id: GO:0035286
name: obsolete leg segmentation
namespace: biological_process
def: "OBSOLETE. Division of a leg into a series of semi-repetitive parts or segments. Most arthropod appendages are visibly segmented; the Drosophila leg for example has nine segments, each separated from the next by a flexible joint." [PMID:10357895]
comment: This term was made obsolete because leg is a mechano-functional grouping, and having both 'leg morphogenesis' and 'hindlimb morphogenesis' terms causes errors in querying.
synonym: "leg segmentation" EXACT []
is_obsolete: true
consider: GO:0035285
consider: GO:0036011

[Term]
id: GO:0035287
name: head segmentation
namespace: biological_process
def: "Partitioning the insect head anlage into a fixed number of segmental units. The number of segments composing the insect head has long been a subject of debate, but it is generally agreed that there are 6 or 7 segments. From anterior to posterior the head segments are the procephalic segments (labral, (ocular), antennal and intercalary) and the gnathal segments (mandibular, maxillary and labial)." [PMID:10477305, PMID:7915837]
comment: See also the fly_anatomy.ontology term 'head segment ; FBbt:00000006' and its children.
is_a: GO:0007389 ! pattern specification process
relationship: part_of GO:0007350 ! blastoderm segmentation
relationship: part_of GO:0060322 ! head development

[Term]
id: GO:0035288
name: anterior head segmentation
namespace: biological_process
def: "Partitioning the insect head anlage into procephalic (labral, (ocular), antennal and intercalary) segments. The procephalic segments lie anterior to the gnathal (posterior head) segments, and are pattered by different segmentation gene cascades to the abdominal, thoracic and posterior head (gnathal) segments." [PMID:15382136]
comment: See also the fly_anatomy.ontology term 'procephalic segment ; FBbt:00000007' and its children.
synonym: "procephalic segmentation" RELATED []
is_a: GO:0035287 ! head segmentation
relationship: part_of GO:0097065 ! anterior head development

[Term]
id: GO:0035289
name: posterior head segmentation
namespace: biological_process
def: "Partitioning the posterior region of the insect head anlage into gnathal (mandibular, maxillary and labial) segments. Unlike the anterior head (procephalic) segments, formation of the posterior head (gnathal) segments occurs by a similar mechanism to trunk segmentation, where a cascade of gap genes, pair-rule genes and segment-polarity genes subdivide the embryo into progressively smaller domains." [PMID:15382136]
comment: See also the fly_anatomy.ontology term 'gnathal segment ; FBbt:00000011' and its children.
synonym: "gnathal segmentation" RELATED []
is_a: GO:0035287 ! head segmentation

[Term]
id: GO:0035290
name: trunk segmentation
namespace: biological_process
def: "Partitioning of the blastoderm embryo into trunk segmental units. In Drosophila, the trunk segments include thoracic segments and abdominal segments A1 to A8." [PMID:1360402]
is_a: GO:0035282 ! segmentation
relationship: part_of GO:0007350 ! blastoderm segmentation

[Term]
id: GO:0035291
name: specification of segmental identity, intercalary segment
namespace: biological_process
def: "The specification of the characteristic structures of the intercalary segment of the anterior head, following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437, PMID:10477305]
comment: See also the fly_anatomy.ontology term 'intercalary segment ; FBbt:00000010'.
is_a: GO:0007380 ! specification of segmental identity, head
relationship: part_of GO:0035288 ! anterior head segmentation

[Term]
id: GO:0035292
name: specification of segmental identity, trunk
namespace: biological_process
def: "The specification of the characteristic structures of trunk segments, following establishment of segment boundaries. In Drosophila, the trunk segments include thoracic segments and abdominal segments A1 to A8. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [PMID:1360402]
is_a: GO:0007379 ! segment specification
relationship: part_of GO:0035290 ! trunk segmentation

[Term]
id: GO:0035293
name: chitin-based larval cuticle pattern formation
namespace: biological_process
def: "The process that gives rise to the patterns of cell differentiation in the chitin-based larval cuticle. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
is_a: GO:0035017 ! cuticle pattern formation
relationship: part_of GO:0008363 ! larval chitin-based cuticle development

[Term]
id: GO:0035294
name: determination of wing disc primordium
namespace: biological_process
def: "Allocation of embryonic cells to the wing disc founder populations, groups of cells that are committed to contribute to the formation of a wing imaginal disc." [ISBN:0879694238]
is_a: GO:0007445 ! determination of imaginal disc primordium
is_a: GO:0035220 ! wing disc development

[Term]
id: GO:0035295
name: tube development
namespace: biological_process
def: "The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts." [PMID:12526790]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007275 ! multicellular organism development

[Term]
id: GO:0035296
name: regulation of tube diameter
namespace: biological_process
def: "Ensuring that a tube is the correct width." [GOC:bf]
is_a: GO:0035150 ! regulation of tube size

[Term]
id: GO:0035297
name: regulation of Malpighian tubule diameter
namespace: biological_process
def: "Ensuring that the Malpighian tubule is the correct width. Malpighian tubules have a uniform circumference along their length; the circumference of the tubes is eight cells during the time the cells are dividing, after which the cells rearrange producting tubes with a cirumference of two cells." [PMID:9286684]
is_a: GO:0035296 ! regulation of tube diameter
is_a: GO:0035298 ! regulation of Malpighian tubule size

[Term]
id: GO:0035298
name: regulation of Malpighian tubule size
namespace: biological_process
def: "Ensuring that a Malpighian tubule is the correct length and diameter." [GOC:bf]
is_a: GO:0035150 ! regulation of tube size
relationship: part_of GO:0007443 ! Malpighian tubule morphogenesis

[Term]
id: GO:0035299
name: inositol pentakisphosphate 2-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + 2 H(+)." [EC:2.7.1.158, RHEA:20316]
synonym: "ATP:1D-myo-inositol 1,3,4,5,6-pentakisphosphate 2-phosphotransferase activity" EXACT [EC:2.7.1.158]
synonym: "Gsl1p" RELATED [EC:2.7.1.158]
synonym: "inositol 1,3,4,5,6-pentakisphosphate 2-kinase activity" EXACT [EC:2.7.1.158]
synonym: "inositol polyphosphate kinase activity" EXACT [EC:2.7.1.158]
synonym: "inositol-pentakisphosphate 2-kinase activity" EXACT [EC:2.7.1.158]
synonym: "Ins(1,3,4,5,6)P5 2-kinase activity" EXACT [EC:2.7.1.158]
synonym: "IP5 2-kinase activity" EXACT [EC:2.7.1.158]
synonym: "Ipk1p" RELATED [EC:2.7.1.158]
xref: EC:2.7.1.158
xref: KEGG:R05202
xref: MetaCyc:RXN-7163
xref: RHEA:20316
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0035300
name: obsolete inositol-1,3,4-trisphosphate 5/6-kinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reactions: ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate, and ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate." [EC:2.7.1.159, PMID:9126335]
comment: This term was made obsolete because it represents two reactions, and should be two separate terms.
synonym: "ATP:1D-myo-inositol 1,3,4-trisphosphate 5-phosphotransferase activity" EXACT [EC:2.7.1.159]
synonym: "inositol 1,3,4-trisphosphate 5-kinase activity" NARROW []
synonym: "inositol 1,3,4-trisphosphate 6-kinase activity" NARROW []
synonym: "inositol trisphosphate 5/6-kinase activity" EXACT [EC:2.7.1.159]
synonym: "inositol-1,3,4-trisphosphate 5/6-kinase activity" EXACT []
synonym: "Ins(1,3,4)P3 5/6-kinase activity" EXACT [EC:2.7.1.159]
synonym: "IP56K" RELATED [EC:2.7.1.159]
is_obsolete: true
consider: GO:0052725
consider: GO:0052726

[Term]
id: GO:0035301
name: Hedgehog signaling complex
namespace: cellular_component
def: "A multiprotein complex that binds microtubules in a Hedgehog-dependent manner, and is required for signal transduction by members of the Hedgehog family of proteins. The core components of the complex are the serine/threonine protein kinase Fused, the kinesin motor protein Costal2 (Cos2), and a zinc finger transcription factor (Gli family members in humans, and Cubitus interruptus (Ci) in Drosophila)." [PMID:10825151, PMID:15057936]
synonym: "Hedgehog signalling complex" EXACT []
synonym: "HSC" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0035302
name: ecdysteroid 25-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the hydroxylation of an ecdysteroid at carbon position 25. Ecdysteroids are a group of polyhydroxylated ketosteroids which initiate post-embryonic development, particularly metamorphosis, in insects and other arthropods." [ISBN:0198506732, PMID:15350618]
comment: Note that in the ecdysteroidogenic pathway, this activity catalyzes the conversion of 2,22,25-trideoxyecdysone (3-beta,5-beta-ketodiol) to 2,22-dideoxyecdysone (3-beta,5-beta-ketotriol).
is_a: GO:0008395 ! steroid hydroxylase activity

[Term]
id: GO:0035303
name: regulation of dephosphorylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of removal of phosphate groups from a molecule." [GOC:bf]
subset: gosubset_prok
is_a: GO:0019220 ! regulation of phosphate metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016311 ! dephosphorylation
relationship: regulates GO:0016311 ! dephosphorylation

[Term]
id: GO:0035304
name: regulation of protein dephosphorylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of removal of phosphate groups from a protein." [GOC:bf]
subset: gosubset_prok
synonym: "regulation of protein amino acid dephosphorylation" EXACT [GOC:bf]
is_a: GO:0031399 ! regulation of protein modification process
is_a: GO:0035303 ! regulation of dephosphorylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006470 ! protein dephosphorylation
relationship: regulates GO:0006470 ! protein dephosphorylation

[Term]
id: GO:0035305
name: negative regulation of dephosphorylation
namespace: biological_process
def: "Any process the stops, prevents, or reduces the frequency, rate or extent of removal of phosphate groups from a molecule." [GOC:bf]
subset: gosubset_prok
synonym: "down regulation of dephosphorylation" EXACT []
synonym: "down-regulation of dephosphorylation" EXACT []
synonym: "downregulation of dephosphorylation" EXACT []
synonym: "inhibition of dephosphorylation" NARROW []
is_a: GO:0035303 ! regulation of dephosphorylation
is_a: GO:0045936 ! negative regulation of phosphate metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016311 ! dephosphorylation
relationship: negatively_regulates GO:0016311 ! dephosphorylation

[Term]
id: GO:0035306
name: positive regulation of dephosphorylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a molecule." [GOC:bf]
subset: gosubset_prok
synonym: "activation of dephosphorylation" NARROW []
synonym: "stimulation of dephosphorylation" NARROW []
synonym: "up regulation of dephosphorylation" EXACT []
synonym: "up-regulation of dephosphorylation" EXACT []
synonym: "upregulation of dephosphorylation" EXACT []
is_a: GO:0035303 ! regulation of dephosphorylation
is_a: GO:0045937 ! positive regulation of phosphate metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016311 ! dephosphorylation
relationship: positively_regulates GO:0016311 ! dephosphorylation

[Term]
id: GO:0035307
name: positive regulation of protein dephosphorylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a protein." [GOC:bf]
subset: gosubset_prok
synonym: "activation of protein amino acid dephosphorylation" NARROW []
synonym: "positive regulation of protein amino acid dephosphorylation" EXACT [GOC:bf]
synonym: "stimulation of protein amino acid dephosphorylation" NARROW []
synonym: "up regulation of protein amino acid dephosphorylation" EXACT []
synonym: "up-regulation of protein amino acid dephosphorylation" EXACT []
synonym: "upregulation of protein amino acid dephosphorylation" EXACT []
is_a: GO:0031401 ! positive regulation of protein modification process
is_a: GO:0035304 ! regulation of protein dephosphorylation
is_a: GO:0035306 ! positive regulation of dephosphorylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006470 ! protein dephosphorylation
relationship: positively_regulates GO:0006470 ! protein dephosphorylation

[Term]
id: GO:0035308
name: negative regulation of protein dephosphorylation
namespace: biological_process
def: "Any process the stops, prevents, or reduces the frequency, rate or extent of removal of phosphate groups from a protein." [GOC:bf]
subset: gosubset_prok
synonym: "down regulation of protein amino acid dephosphorylation" EXACT []
synonym: "down-regulation of protein amino acid dephosphorylation" EXACT []
synonym: "downregulation of protein amino acid dephosphorylation" EXACT []
synonym: "inhibition of protein amino acid dephosphorylation" NARROW []
synonym: "negative regulation of protein amino acid dephosphorylation" EXACT [GOC:bf]
is_a: GO:0031400 ! negative regulation of protein modification process
is_a: GO:0035304 ! regulation of protein dephosphorylation
is_a: GO:0035305 ! negative regulation of dephosphorylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006470 ! protein dephosphorylation
relationship: negatively_regulates GO:0006470 ! protein dephosphorylation

[Term]
id: GO:0035309
name: wing and notum subfield formation
namespace: biological_process
def: "The regionalization process that subdivides the wing imaginal disc into the wing and notum (body wall) subfields, thus determining whether cells ultimately differentiate wing or notum-specific structures." [PMID:10860999]
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0035220 ! wing disc development

[Term]
id: GO:0035310
name: notum cell fate specification
namespace: biological_process
def: "The process in which a cell in the larval wing imaginal disc becomes capable of differentiating autonomously into a notum cell, if left in its normal environment." [PMID:10860999]
is_a: GO:0060573 ! cell fate specification involved in pattern specification
relationship: part_of GO:0035309 ! wing and notum subfield formation

[Term]
id: GO:0035311
name: wing cell fate specification
namespace: biological_process
def: "The process in which a cell in the larval wing imaginal disc becomes capable of differentiating autonomously into a wing cell, if left in its normal environment." [PMID:10860999]
is_a: GO:0060573 ! cell fate specification involved in pattern specification
relationship: part_of GO:0035309 ! wing and notum subfield formation

[Term]
id: GO:0035312
name: 5'-3' exodeoxyribonuclease activity
namespace: molecular_function
def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a DNA molecule." [ISBN:0198547684]
is_a: GO:0008409 ! 5'-3' exonuclease activity
is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0035313
name: wound healing, spreading of epidermal cells
namespace: biological_process
def: "The migration of an epidermal cell along or through a wound gap that contributes to the reestablishment of a continuous epidermis." [GOC:bf, PMID:15269788]
is_a: GO:0044319 ! wound healing, spreading of cells

[Term]
id: GO:0035314
name: scab formation
namespace: biological_process
def: "Formation of hardened covering (a scab) at a wound site. The scab has multiple functions including limiting blood loss, providing structural stability to the wound and guarding against infection." [GOC:bf, PMID:15269788]
is_a: GO:0044707 ! single-multicellular organism process
relationship: part_of GO:0042060 ! wound healing

[Term]
id: GO:0035315
name: hair cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a hair cell." [GOC:bf]
is_a: GO:0009913 ! epidermal cell differentiation
is_a: GO:0030182 ! neuron differentiation

[Term]
id: GO:0035316
name: non-sensory hair organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of non-sensory hairs. These hairs are polarized cellular extensions that cover much of the insect epidermis." [GOC:mtg_sensu, PMID:11064425]
comment: See also the fly_anatomy.ontology term 'trichome ; FBbt:00004979'.
synonym: "non-sensory hair organization and biogenesis" RELATED [GOC:mah]
synonym: "trichome organisation" BROAD []
synonym: "trichome organization and biogenesis" BROAD []
is_a: GO:0030030 ! cell projection organization
relationship: part_of GO:0035315 ! hair cell differentiation

[Term]
id: GO:0035317
name: imaginal disc-derived wing hair organization
namespace: biological_process
def: "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of an imaginal disc-derived wing hair. A wing hair is an actin-rich, polarized, non-sensory apical projection that protrudes from each of the approximately 30,000 wing epithelial cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11064425, PMID:12540853]
comment: See also the fly_anatomy.ontology term 'wing hair ; FBbt:00004340'.
synonym: "imaginal disc-derived wing hair organization and biogenesis" RELATED [GOC:mah]
synonym: "wing hair organisation" EXACT [GOC:curators]
synonym: "wing hair organization and biogenesis" RELATED [GOC:mah]
synonym: "wing trichome organization and biogenesis" EXACT []
is_a: GO:0035316 ! non-sensory hair organization
relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis

[Term]
id: GO:0035318
name: imaginal disc-derived wing hair outgrowth
namespace: biological_process
def: "Extrusion of a cellular projection from the apical membrane of an epithelial cell in an imaginal disc-derived wing. Outgrowth initiates approximately 35 hours after puparium formation from the distal side of the cell, and at this stage the cellular extension is termed a prehair." [GOC:mtg_sensu, PMID:11064425, PMID:8947551]
synonym: "wing hair outgrowth" EXACT []
synonym: "wing prehair outgrowth" RELATED []
is_a: GO:0009886 ! post-embryonic morphogenesis
is_a: GO:0048858 ! cell projection morphogenesis
relationship: part_of GO:0035317 ! imaginal disc-derived wing hair organization

[Term]
id: GO:0035319
name: imaginal disc-derived wing hair elongation
namespace: biological_process
def: "Growth of a prehair in the approximately 10 hour period following its emergence from an epidermal cell in an imaginal disc-derived wing. Prehair elongation is guided and/or driven by the polymerization of actin filaments and the orderly crosslinking of filaments into bundles." [GOC:mtg_sensu, PMID:11832234]
synonym: "wing hair elongation" EXACT []
synonym: "wing prehair extension" RELATED []
is_a: GO:0009886 ! post-embryonic morphogenesis
is_a: GO:0048858 ! cell projection morphogenesis
relationship: part_of GO:0035317 ! imaginal disc-derived wing hair organization

[Term]
id: GO:0035320
name: imaginal disc-derived wing hair site selection
namespace: biological_process
def: "Determination of the site in the cell of an imaginal disc-derived wing at which a prehair initiates outgrowth. Restriction of prehair initiation to the distalmost part of a cell is essential to ensure that each wing epithelial cell produces one adult hair that points distally." [GOC:mtg_transport, ISBN:0815340729, PMID:8947551]
synonym: "prehair localization" RELATED []
synonym: "wing hair site selection" EXACT []
is_a: GO:0022606 ! establishment of proximal/distal cell polarity
relationship: part_of GO:0001737 ! establishment of imaginal disc-derived wing hair orientation

[Term]
id: GO:0035321
name: maintenance of imaginal disc-derived wing hair orientation
namespace: biological_process
def: "Ensuring that hairs in the imaginal disc-derived wing continue to point distally during development, following the initial establishment of wing hair polarity." [GOC:mtg_sensu, PMID:15501220]
synonym: "maintenance of wing hair orientation" EXACT []
is_a: GO:0009954 ! proximal/distal pattern formation
relationship: part_of GO:0035317 ! imaginal disc-derived wing hair organization

[Term]
id: GO:0035322
name: mesenchymal cell migration involved in limb bud formation
namespace: biological_process
def: "The orderly movement of a mesenchymal cell from one site to another that will contribute to the formation of a limb bud." [GOC:dgh]
is_a: GO:0090497 ! mesenchymal cell migration
intersection_of: GO:0090497 ! mesenchymal cell migration
intersection_of: part_of GO:0060174 ! limb bud formation
relationship: part_of GO:0060174 ! limb bud formation
relationship: part_of GO:0090496 ! mesenchyme migration involved in limb bud formation
created_by: rfoulger
creation_date: 2010-02-24T02:05:14Z

[Term]
id: GO:0035323
name: male germline ring canal
namespace: cellular_component
def: "An intercellular bridge that connects the germline cells of a male cyst." [PMID:9635420]
synonym: "spermatocyte ring canal" NARROW []
synonym: "testicular ring canal" NARROW []
is_a: GO:0045172 ! germline ring canal
created_by: rfoulger
creation_date: 2010-02-25T11:05:14Z

[Term]
id: GO:0035324
name: female germline ring canal
namespace: cellular_component
def: "An intercellular bridge that connects the germline cells of a female cyst." [PMID:9635420]
synonym: "nurse cell ring canal" NARROW []
synonym: "ovarian ring canal" NARROW []
is_a: GO:0045172 ! germline ring canal
created_by: rfoulger
creation_date: 2010-02-25T11:06:41Z

[Term]
id: GO:0035325
name: Toll-like receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a Toll-like protein, a pattern recognition receptor that binds pattern motifs from a variety of microbial sources to initiate an innate immune response." [PMID:19076341]
synonym: "TLR binding" EXACT []
is_a: GO:0005102 ! receptor binding
created_by: rfoulger
creation_date: 2010-02-26T10:11:55Z

[Term]
id: GO:0035326
name: enhancer binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an enhancer, a transcription regulatory region that is somewhat distal from the core promoter and which enhances transcription from that promoter." [GOC:sart, GOC:txnOH, SO:0000165]
is_a: GO:0044212 ! transcription regulatory region DNA binding
created_by: rfoulger
creation_date: 2010-02-26T10:17:00Z

[Term]
id: GO:0035327
name: transcriptionally active chromatin
namespace: cellular_component
def: "The ordered and organized complex of DNA and protein that forms regions of the chromosome that are being actively transcribed." [GOC:sart, PMID:17965872]
is_a: GO:0000785 ! chromatin
created_by: rfoulger
creation_date: 2010-02-26T10:23:02Z

[Term]
id: GO:0035328
name: transcriptionally silent chromatin
namespace: cellular_component
def: "The ordered and organized complex of DNA and protein that forms regions of the chromosome that are not being actively transcribed." [GOC:sart, PMID:17965872]
synonym: "transcriptionally inactive chromatin" EXACT []
is_a: GO:0000785 ! chromatin
created_by: rfoulger
creation_date: 2010-02-26T10:24:13Z

[Term]
id: GO:0035329
name: hippo signaling
namespace: biological_process
def: "The series of molecular signals mediated by the serine/threonine kinase Hippo or one of its orthologs. In Drosophila, Hippo in complex with the scaffold protein Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) transcriptional activator. The core fly components hippo, sav, wts and mats are conserved in mammals as STK4/3 (MST1/2), SAV1/WW45, LATS1/2 and MOB1." [PMID:17318211, PMID:18328423]
synonym: "hippo signal transduction" EXACT [GOC:signaling]
synonym: "hippo signaling cascade" RELATED [GOC:signaling]
synonym: "hippo signaling pathway" EXACT []
synonym: "hippo signalling cascade" RELATED [GOC:mah]
synonym: "Salvador-Warts-Hippo signaling pathway" NARROW []
synonym: "SWH pathway" NARROW []
is_a: GO:0035556 ! intracellular signal transduction
created_by: rfoulger
creation_date: 2010-02-26T10:43:33Z

[Term]
id: GO:0035330
name: regulation of hippo signaling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hippo signaling." [GOC:bf]
synonym: "regulation of hippo signaling cascade" RELATED [GOC:signaling]
synonym: "regulation of hippo signaling pathway" EXACT []
synonym: "regulation of hippo signalling cascade" RELATED [GOC:mah]
is_a: GO:1902531 ! regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035329 ! hippo signaling
relationship: regulates GO:0035329 ! hippo signaling
created_by: rfoulger
creation_date: 2010-02-26T10:53:05Z

[Term]
id: GO:0035331
name: negative regulation of hippo signaling
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of hippo signaling." [GOC:bf]
synonym: "negative regulation of hippo signaling cascade" RELATED [GOC:signaling]
synonym: "negative regulation of hippo signaling pathway" EXACT []
synonym: "negative regulation of hippo signalling cascade" RELATED [GOC:mah]
is_a: GO:0035330 ! regulation of hippo signaling
is_a: GO:1902532 ! negative regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035329 ! hippo signaling
relationship: negatively_regulates GO:0035329 ! hippo signaling
created_by: rfoulger
creation_date: 2010-02-26T10:54:19Z

[Term]
id: GO:0035332
name: positive regulation of hippo signaling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hippo signaling." [GOC:bf]
synonym: "positive regulation of hippo signaling cascade" RELATED [GOC:signaling]
synonym: "positive regulation of hippo signaling pathway" EXACT []
synonym: "positive regulation of hippo signalling cascade" RELATED [GOC:mah]
is_a: GO:0035330 ! regulation of hippo signaling
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035329 ! hippo signaling
relationship: positively_regulates GO:0035329 ! hippo signaling
created_by: rfoulger
creation_date: 2010-02-26T10:54:59Z

[Term]
id: GO:0035333
name: Notch receptor processing, ligand-dependent
namespace: biological_process
def: "The proteolytic cleavages to the Notch protein that occur as a result of ligand binding. Ligand binding at the cell surface exposes an otherwise inaccessible cleavage site in the extracellular portion of Notch, which when cleaved releases a membrane-tethered form of the Notch intracellular domain. Subsequent cleavage within the transmembrane domain then leads to the release of the soluble Notch intracellular domain (NICD)." [GOC:bf, PMID:12651094]
synonym: "Notch S2 cleavage" NARROW [PMID:12651094]
synonym: "Notch S3 cleavage" NARROW [PMID:12651094]
is_a: GO:0031293 ! membrane protein intracellular domain proteolysis
relationship: part_of GO:0007219 ! Notch signaling pathway
relationship: part_of GO:0007220 ! Notch receptor processing
created_by: rfoulger
creation_date: 2010-02-26T02:31:31Z

[Term]
id: GO:0035334
name: Notch receptor processing, ligand-independent
namespace: biological_process
def: "The proteolytic cleavages to the Notch protein that occur prior to ligand binding. A primary cleavage event within the extracellular domain whilst the Notch protein in still in the secretory pathway, leads to the transportation of a processed heterodimer to the cell surface." [GOC:bf, PMID:12651094]
synonym: "Notch S1 cleavage" NARROW [PMID:12651094]
is_a: GO:0016485 ! protein processing
relationship: part_of GO:0007220 ! Notch receptor processing
created_by: rfoulger
creation_date: 2010-02-26T02:32:46Z

[Term]
id: GO:0035335
name: peptidyl-tyrosine dephosphorylation
namespace: biological_process
def: "The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine." [GOC:bf]
is_a: GO:0006470 ! protein dephosphorylation
created_by: rfoulger
creation_date: 2010-03-01T01:09:14Z

[Term]
id: GO:0035336
name: long-chain fatty-acyl-CoA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more." [CHEBI:33184, ISBN:0198506732]
synonym: "long-chain fatty acyl CoA metabolic process" EXACT [GOC:curators]
synonym: "long-chain fatty acyl-CoA metabolism" EXACT []
is_a: GO:0035337 ! fatty-acyl-CoA metabolic process
created_by: rfoulger
creation_date: 2010-03-02T11:01:43Z

[Term]
id: GO:0035337
name: fatty-acyl-CoA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group." [ISBN:0198506732]
synonym: "fatty acyl CoA metabolic process" EXACT [GOC:curators]
synonym: "fatty-acyl-CoA metabolism" EXACT []
is_a: GO:0006637 ! acyl-CoA metabolic process
created_by: rfoulger
creation_date: 2010-03-02T11:05:48Z

[Term]
id: GO:0035338
name: long-chain fatty-acyl-CoA biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a long-chain fatty-acyl-CoA any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more." [CHEBI:33184, ISBN:0198506732]
synonym: "long-chain fatty acyl CoA biosynthetic process" EXACT [GOC:curators]
synonym: "long-chain fatty-acyl-CoA anabolism" EXACT []
synonym: "long-chain fatty-acyl-CoA biosynthesis" EXACT []
synonym: "long-chain fatty-acyl-CoA formation" EXACT []
synonym: "long-chain fatty-acyl-CoA synthesis" EXACT []
xref: Reactome:REACT_101362 "Fatty Acyl-CoA Biosynthesis, Rattus norvegicus"
xref: Reactome:REACT_101582 "Synthesis of very long-chain fatty acyl-CoAs, Schizosaccharomyces pombe"
xref: Reactome:REACT_103020 "Synthesis of very long-chain fatty acyl-CoAs, Caenorhabditis elegans"
xref: Reactome:REACT_104080 "Fatty Acyl-CoA Biosynthesis, Sus scrofa"
xref: Reactome:REACT_106117 "Fatty Acyl-CoA Biosynthesis, Drosophila melanogaster"
xref: Reactome:REACT_106846 "Synthesis of very long-chain fatty acyl-CoAs, Oryza sativa"
xref: Reactome:REACT_108141 "Synthesis of very long-chain fatty acyl-CoAs, Rattus norvegicus"
xref: Reactome:REACT_108421 "Synthesis of very long-chain fatty acyl-CoAs, Canis familiaris"
xref: Reactome:REACT_110155 "Synthesis of very long-chain fatty acyl-CoAs, Saccharomyces cerevisiae"
xref: Reactome:REACT_110390 "Synthesis of very long-chain fatty acyl-CoAs, Gallus gallus"
xref: Reactome:REACT_110964 "Fatty Acyl-CoA Biosynthesis, Mus musculus"
xref: Reactome:REACT_112257 "Synthesis of very long-chain fatty acyl-CoAs, Dictyostelium discoideum"
xref: Reactome:REACT_112844 "Synthesis of very long-chain fatty acyl-CoAs, Plasmodium falciparum"
xref: Reactome:REACT_113523 "Synthesis of very long-chain fatty acyl-CoAs, Mycobacterium tuberculosis"
xref: Reactome:REACT_1319 "Fatty Acyl-CoA Biosynthesis, Homo sapiens"
xref: Reactome:REACT_28916 "Fatty Acyl-CoA Biosynthesis, Dictyostelium discoideum"
xref: Reactome:REACT_32041 "Synthesis of very long-chain fatty acyl-CoAs, Taeniopygia guttata"
xref: Reactome:REACT_32893 "Synthesis of very long-chain fatty acyl-CoAs, Mus musculus"
xref: Reactome:REACT_33411 "Synthesis of very long-chain fatty acyl-CoAs, Sus scrofa"
xref: Reactome:REACT_33584 "Fatty Acyl-CoA Biosynthesis, Caenorhabditis elegans"
xref: Reactome:REACT_380 "Synthesis of very long-chain fatty acyl-CoAs, Homo sapiens"
xref: Reactome:REACT_77990 "Fatty Acyl-CoA Biosynthesis, Mycobacterium tuberculosis"
xref: Reactome:REACT_78691 "Fatty Acyl-CoA Biosynthesis, Arabidopsis thaliana"
xref: Reactome:REACT_78693 "Synthesis of very long-chain fatty acyl-CoAs, Bos taurus"
xref: Reactome:REACT_78780 "Fatty Acyl-CoA Biosynthesis, Gallus gallus"
xref: Reactome:REACT_79742 "Fatty Acyl-CoA Biosynthesis, Bos taurus"
xref: Reactome:REACT_79744 "Fatty Acyl-CoA Biosynthesis, Xenopus tropicalis"
xref: Reactome:REACT_81014 "Fatty Acyl-CoA Biosynthesis, Schizosaccharomyces pombe"
xref: Reactome:REACT_82722 "Fatty Acyl-CoA Biosynthesis, Danio rerio"
xref: Reactome:REACT_83786 "Fatty Acyl-CoA Biosynthesis, Oryza sativa"
xref: Reactome:REACT_84277 "Synthesis of very long-chain fatty acyl-CoAs, Arabidopsis thaliana"
xref: Reactome:REACT_84945 "Fatty Acyl-CoA Biosynthesis, Plasmodium falciparum"
xref: Reactome:REACT_89972 "Fatty Acyl-CoA Biosynthesis, Taeniopygia guttata"
xref: Reactome:REACT_90497 "Fatty Acyl-CoA Biosynthesis, Canis familiaris"
xref: Reactome:REACT_94056 "Synthesis of very long-chain fatty acyl-CoAs, Xenopus tropicalis"
xref: Reactome:REACT_94507 "Fatty Acyl-CoA Biosynthesis, Saccharomyces cerevisiae"
xref: Reactome:REACT_94516 "Synthesis of very long-chain fatty acyl-CoAs, Drosophila melanogaster"
xref: Reactome:REACT_96554 "Synthesis of very long-chain fatty acyl-CoAs, Danio rerio"
is_a: GO:0035336 ! long-chain fatty-acyl-CoA metabolic process
is_a: GO:0046949 ! fatty-acyl-CoA biosynthetic process
created_by: rfoulger
creation_date: 2010-03-02T11:07:15Z

[Term]
id: GO:0035339
name: SPOTS complex
namespace: cellular_component
def: "A multiprotein complex at least composed of serine palmitoyltransferases and ORM proteins (known as ORMDL proteins in mammals and other higher vertebrates) that plays a key role in sphingolipid homeostasis." [PMID:20182505]
synonym: "serine palmitoyltransferase, Orm1/2, Tsc3 and Sac1 complex" NARROW []
is_a: GO:0017059 ! serine C-palmitoyltransferase complex
created_by: rfoulger
creation_date: 2010-03-03T10:28:42Z

[Term]
id: GO:0035340
name: inosine transport
namespace: biological_process
def: "The directed movement of the purine ribonucleoside inosine, also known as hypoxanthine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:17596, PMID:19135251]
synonym: "hypoxanthine riboside transport" EXACT []
is_a: GO:0015858 ! nucleoside transport
created_by: rfoulger
creation_date: 2010-03-04T10:00:58Z

[Term]
id: GO:0035341
name: regulation of inosine transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of inosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf]
synonym: "regulation of hypoxanthine riboside transport" EXACT []
is_a: GO:0032245 ! regulation of purine nucleoside transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035340 ! inosine transport
relationship: regulates GO:0035340 ! inosine transport
created_by: rfoulger
creation_date: 2010-03-04T10:03:51Z

[Term]
id: GO:0035342
name: positive regulation of inosine transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of inosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf]
synonym: "positive regulation of hypoxanthine riboside transport" EXACT []
is_a: GO:0032248 ! positive regulation of purine nucleoside transport
is_a: GO:0035341 ! regulation of inosine transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035340 ! inosine transport
relationship: positively_regulates GO:0035340 ! inosine transport
created_by: rfoulger
creation_date: 2010-03-04T10:05:03Z

[Term]
id: GO:0035343
name: negative regulation of inosine transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of inosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf]
synonym: "negative regulation of hypoxanthine riboside transport" EXACT []
is_a: GO:0032247 ! negative regulation of purine nucleoside transport
is_a: GO:0035341 ! regulation of inosine transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035340 ! inosine transport
relationship: negatively_regulates GO:0035340 ! inosine transport
created_by: rfoulger
creation_date: 2010-03-04T10:06:07Z

[Term]
id: GO:0035344
name: hypoxanthine transport
namespace: biological_process
def: "The directed movement of hypoxanthine, 6-hydroxypurine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:17368, GOC:sl]
synonym: "6-hydroxypurine transport" EXACT []
synonym: "hypoxanthine transmembrane transport" EXACT [GOC:mah]
is_a: GO:0006863 ! purine nucleobase transport
created_by: rfoulger
creation_date: 2010-03-04T10:39:55Z

[Term]
id: GO:0035345
name: regulation of hypoxanthine transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of hypoxanthine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf]
synonym: "regulation of 6-hydroxypurine transport" EXACT []
is_a: GO:0032239 ! regulation of nucleobase-containing compound transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035344 ! hypoxanthine transport
relationship: regulates GO:0035344 ! hypoxanthine transport
created_by: rfoulger
creation_date: 2010-03-04T10:42:04Z

[Term]
id: GO:0035346
name: positive regulation of hypoxanthine transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of hypoxanthine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf]
synonym: "positive regulation of 6-hydroxypurine transport" EXACT []
is_a: GO:0032241 ! positive regulation of nucleobase-containing compound transport
is_a: GO:0035345 ! regulation of hypoxanthine transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035344 ! hypoxanthine transport
relationship: positively_regulates GO:0035344 ! hypoxanthine transport
created_by: rfoulger
creation_date: 2010-03-04T10:42:48Z

[Term]
id: GO:0035347
name: negative regulation of hypoxanthine transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of hypoxanthine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf]
synonym: "negative regulation of 6-hydroxypurine transport" EXACT []
is_a: GO:0032240 ! negative regulation of nucleobase-containing compound transport
is_a: GO:0035345 ! regulation of hypoxanthine transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035344 ! hypoxanthine transport
relationship: negatively_regulates GO:0035344 ! hypoxanthine transport
created_by: rfoulger
creation_date: 2010-03-04T10:43:53Z

[Term]
id: GO:0035348
name: acetyl-CoA transmembrane transport
namespace: biological_process
def: "The process in which acetyl-CoA is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis." [GO:bf]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "acetyl-CoA membrane transport" EXACT []
is_a: GO:0015876 ! acetyl-CoA transport
is_a: GO:0098656 ! anion transmembrane transport
created_by: rfoulger
creation_date: 2010-03-04T03:42:23Z

[Term]
id: GO:0035349
name: coenzyme A transmembrane transport
namespace: biological_process
def: "The process in which coenzyme A is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [GOC:bf]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "coenzyme A membrane transport" EXACT []
is_a: GO:0015880 ! coenzyme A transport
is_a: GO:0071106 ! adenosine 3',5'-bisphosphate transmembrane transport
is_a: GO:0098656 ! anion transmembrane transport
created_by: rfoulger
creation_date: 2010-03-04T03:44:33Z

[Term]
id: GO:0035350
name: FAD transmembrane transport
namespace: biological_process
def: "The process in which flavin-adenine dinucleotide (FAD) is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. FAD forms the coenzyme of the prosthetic group of various flavoprotein oxidoreductase enzymes, in which it functions as an electron acceptor by being reversibly converted to its reduced form." [GOC:bf, ISBN:0198506732]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "FAD membrane transport" EXACT []
is_a: GO:0015883 ! FAD transport
is_a: GO:0098656 ! anion transmembrane transport
is_a: GO:1901679 ! nucleotide transmembrane transport
created_by: rfoulger
creation_date: 2010-03-04T03:45:11Z

[Term]
id: GO:0035351
name: heme transmembrane transport
namespace: biological_process
def: "The process in which heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:bf]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "heme membrane transport" EXACT []
is_a: GO:0015886 ! heme transport
is_a: GO:0055085 ! transmembrane transport
created_by: rfoulger
creation_date: 2010-03-04T03:45:46Z

[Term]
id: GO:0035352
name: NAD transmembrane transport
namespace: biological_process
def: "The process in which nicotinamide adenine dinucleotide is transported from one side of a membrane to the other by means of some agent such as a transporter or pore; transport may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:bf]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "NAD membrane transport" EXACT []
is_a: GO:0043132 ! NAD transport
is_a: GO:1901679 ! nucleotide transmembrane transport
created_by: rfoulger
creation_date: 2010-03-04T03:46:20Z

[Term]
id: GO:0035353
name: nicotinamide mononucleotide transmembrane transport
namespace: biological_process
def: "The process in which nicotinamide mononucleotide is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. Nicotinamide mononucleotide is a ribonucleotide in which the nitrogenous base, nicotinamide, is in beta-n-glycosidic linkage with the c-1 position of d-ribose. It is a constituent of NAD and NADP." [GOC:bf, ISBN:0721662544]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "nicotinamide mononucleotide membrane transport" EXACT []
is_a: GO:0015890 ! nicotinamide mononucleotide transport
is_a: GO:1901679 ! nucleotide transmembrane transport
created_by: rfoulger
creation_date: 2010-03-04T03:46:55Z

[Term]
id: GO:0035354
name: Toll-like receptor 1-Toll-like receptor 2 protein complex
namespace: cellular_component
alt_id: GO:0038125
def: "A heterodimeric protein complex containing Toll-like receptor 1 (TLR1) and Toll-like receptor 2 (TLR2)." [GOC:add, GOC:signaling, PMID:17889651, PMID:21481769]
synonym: "TLR1-TLR2 protein complex" EXACT []
synonym: "TLR1:TLR2 complex" EXACT []
synonym: "TLR2:TLR1 heterodimer" EXACT [GOC:bf]
synonym: "toll-like receptor TLR1:TLR2 heterodimeric complex" EXACT [GOC:bf]
xref: Reactome:REACT_8486.1 "TLR1:TLR2"
is_a: GO:0098802 ! plasma membrane receptor complex
created_by: rfoulger
creation_date: 2010-03-04T04:35:44Z

[Term]
id: GO:0035355
name: Toll-like receptor 2-Toll-like receptor 6 protein complex
namespace: cellular_component
alt_id: GO:0038126
def: "A heterodimeric protein complex containing Toll-like receptor 2 (TLR2) and Toll-like receptor 6 (TLR6)." [GOC:add, GOC:signaling, PMID:19931471, PMID:21481769]
synonym: "TLR2-TLR6 protein complex" EXACT []
synonym: "TLR2:TLR6 heterodimer" EXACT [GOC:bf]
synonym: "TLR6:TLR2 complex" EXACT []
synonym: "toll-like receptor TLR6:TLR2 heterodimeric complex" EXACT [GOC:bf]
xref: Reactome:REACT_8554.1 "TLR6:TLR2"
is_a: GO:0098802 ! plasma membrane receptor complex
created_by: rfoulger
creation_date: 2010-03-04T04:37:00Z

[Term]
id: GO:0035356
name: cellular triglyceride homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of triglyceride within a cell or between a cell and its external environment." [GOC:BHF]
is_a: GO:0055082 ! cellular chemical homeostasis
is_a: GO:0070328 ! triglyceride homeostasis
created_by: rfoulger
creation_date: 2010-03-05T10:28:11Z

[Term]
id: GO:0035357
name: peroxisome proliferator activated receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by binding of a ligand to any of the peroxisome proliferator activated receptors (alpha, beta or gamma) in the nuclear membrane, and ending with the initiation or termination of the transcription of target genes." [GOC:BHF, PMID:18221086]
synonym: "peroxisome proliferator activated receptor signalling pathway" EXACT [GOC:mah]
synonym: "peroxisome proliferator-activated receptor signaling pathway" EXACT []
synonym: "PPAR signaling pathway" EXACT []
is_a: GO:0030522 ! intracellular receptor signaling pathway
created_by: rfoulger
creation_date: 2010-03-05T10:30:10Z

[Term]
id: GO:0035358
name: regulation of peroxisome proliferator activated receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway." [GOC:bf]
synonym: "regulation of peroxisome proliferator activated receptor signalling pathway" EXACT [GOC:mah]
synonym: "regulation of peroxisome proliferator-activated receptor signaling pathway" EXACT []
synonym: "regulation of PPAR signaling pathway" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035357 ! peroxisome proliferator activated receptor signaling pathway
relationship: regulates GO:0035357 ! peroxisome proliferator activated receptor signaling pathway
created_by: rfoulger
creation_date: 2010-03-05T10:39:37Z

[Term]
id: GO:0035359
name: negative regulation of peroxisome proliferator activated receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway." [GOC:bf]
synonym: "negative regulation of peroxisome proliferator activated receptor signalling pathway" EXACT [GOC:mah]
synonym: "negative regulation of peroxisome proliferator-activated receptor signaling pathway" EXACT []
synonym: "negative regulation of PPAR signaling pathway" EXACT []
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0035358 ! regulation of peroxisome proliferator activated receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035357 ! peroxisome proliferator activated receptor signaling pathway
relationship: negatively_regulates GO:0035357 ! peroxisome proliferator activated receptor signaling pathway
created_by: rfoulger
creation_date: 2010-03-05T10:41:35Z

[Term]
id: GO:0035360
name: positive regulation of peroxisome proliferator activated receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway." [GOC:bf]
synonym: "positive regulation of peroxisome proliferator activated receptor signalling pathway" EXACT [GOC:mah]
synonym: "positive regulation of peroxisome proliferator-activated receptor signaling pathway" EXACT []
synonym: "positive regulation of PPAR signaling pathway" EXACT []
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0035358 ! regulation of peroxisome proliferator activated receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035357 ! peroxisome proliferator activated receptor signaling pathway
relationship: positively_regulates GO:0035357 ! peroxisome proliferator activated receptor signaling pathway
created_by: rfoulger
creation_date: 2010-03-05T10:43:10Z

[Term]
id: GO:0035361
name: Cul8-RING ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex in which a cullin from the Cul8 subfamily and a RING domain protein form the catalytic core. In S. cerevisiae, Mms1p acts as the adaptor protein and substrate specificity is conferred by any of a number of different proteins." [GOC:krc, PMID:20139071]
is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex
created_by: rfoulger
creation_date: 2010-03-05T02:41:12Z

[Term]
id: GO:0035362
name: protein-DNA ISRE complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex, in which the complex is formed through interaction of the protein(s) with a interferon-stimulated response element (ISRE) in the DNA." [GOC:amm, PMID:11747630]
synonym: "protein-DNA interferon-stimulated response element complex assembly" EXACT []
is_a: GO:0065004 ! protein-DNA complex assembly
created_by: rfoulger
creation_date: 2010-03-10T10:40:09Z

[Term]
id: GO:0035363
name: histone locus body
namespace: cellular_component
def: "A nuclear body associated with the histone gene locus that is thought to contain all of the factors necessary for histone mRNA transcription and pre-mRNA processing. In Drosophila, U7 snRNP is located in the histone locus body rather than the distinct Cajal body." [GOC:sart, PMID:16533947, PMID:18927579, PMID:19620235]
synonym: "HLB" EXACT [PMID:16533947, PMID:18927579, PMID:19620235]
is_a: GO:0016604 ! nuclear body
created_by: rfoulger
creation_date: 2010-03-10T10:44:01Z

[Term]
id: GO:0035364
name: thymine transport
namespace: biological_process
def: "The directed movement of thymine, 5-methyluracil, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GO:sl]
synonym: "5-methyluracil transport" EXACT [CHEBI:17821]
synonym: "thymine transmembrane transport" EXACT [GOC:mah]
is_a: GO:0015855 ! pyrimidine nucleobase transport
created_by: rfoulger
creation_date: 2010-03-11T10:20:24Z

[Term]
id: GO:0035365
name: regulation of thymine transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of thymine, 5-methyluracil, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf, GOC:sl]
synonym: "regulation of 5-methyluracil transport" EXACT []
is_a: GO:0032239 ! regulation of nucleobase-containing compound transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035364 ! thymine transport
relationship: regulates GO:0035364 ! thymine transport
created_by: rfoulger
creation_date: 2010-03-11T10:22:54Z

[Term]
id: GO:0035366
name: negative regulation of thymine transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of thymine, 5-methyluracil, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf, GOC:sl]
synonym: "negative regulation of 5-methyluracil transport" EXACT []
is_a: GO:0032240 ! negative regulation of nucleobase-containing compound transport
is_a: GO:0035365 ! regulation of thymine transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035364 ! thymine transport
relationship: negatively_regulates GO:0035364 ! thymine transport
created_by: rfoulger
creation_date: 2010-03-11T10:23:42Z

[Term]
id: GO:0035367
name: positive regulation of thymine transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of thymine, 5-methyluracil, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf, GOC:sl]
synonym: "positive regulation of 5-methyluracil transport" EXACT []
is_a: GO:0032241 ! positive regulation of nucleobase-containing compound transport
is_a: GO:0035365 ! regulation of thymine transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035364 ! thymine transport
relationship: positively_regulates GO:0035364 ! thymine transport
created_by: rfoulger
creation_date: 2010-03-11T10:24:25Z

[Term]
id: GO:0035368
name: selenocysteine insertion sequence binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the selenocysteine insertion sequence (SECIS), a regulatory sequence within mRNA which directs incorporation of a selenocysteine at a stop codon (UGA) during translation." [GOC:imk, PMID:10760958]
synonym: "SECIS binding" EXACT []
is_a: GO:0003729 ! mRNA binding
created_by: rfoulger
creation_date: 2010-03-11T10:42:28Z

[Term]
id: GO:0035369
name: pre-B cell receptor complex
namespace: cellular_component
def: "An immunoglobulin-like complex that is present in at least the plasma membrane of pre-B cells, and that is composed of two identical immunoglobulin heavy chains and two surrogate light chains, each composed of the lambda-5 and VpreB proteins, and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [GOC:add, ISBN:0781765196, PMID:16464608, PMID:17306522]
comment: Despite its name, the pre-BCR is not a receptor complex, as it appears to provide a low level of signal not dependent on a ligand, but rather simply on correct assembly of the complex as a measure for correct Ig heavy chain recombination and folding. A significant proportion of pre-BCR complexes fail to reach the cell surface, and in some cases may provide their signaling function from the trans-Golgi network or lysosome.
synonym: "pre-BCR" EXACT []
is_a: GO:0098796 ! membrane protein complex
created_by: rfoulger
creation_date: 2010-03-11T10:46:10Z

[Term]
id: GO:0035370
name: UBC13-UEV1A complex
namespace: cellular_component
def: "A heterodimeric ubiquitin conjugating enzyme complex that catalyzes assembly of K63-linked polyubiquitin chains and is involved in NF-kappaB activation. In humans at least, the complex comprises the ubiquitin-conjugating enzyme UBC13 and ubiquitin-conjugating enzyme variant 1A (UEV1A)." [GOC:amm, PMID:16129784]
is_a: GO:0031371 ! ubiquitin conjugating enzyme complex
created_by: rfoulger
creation_date: 2010-03-11T10:53:09Z

[Term]
id: GO:0035371
name: microtubule plus-end
namespace: cellular_component
def: "The growing (plus) end of a microtubule. In vitro, microtubules polymerize more quickly at the plus end than at the minus end. In vivo, microtubule growth occurs only at the plus end, and the plus end switches between periods of growth and shortening, a behavior known as dynamic instability." [GOC:bf, GOC:lb, PMID:12700769, PMID:16643273]
synonym: "growing microtubule plus end" EXACT []
synonym: "microtubule plus end" EXACT []
is_a: GO:1990752 ! microtubule end
relationship: part_of GO:0005874 ! microtubule
created_by: rfoulger
creation_date: 2010-03-11T10:55:00Z

[Term]
id: GO:0035372
name: protein localization to microtubule
namespace: biological_process
def: "A process in which a protein is transported to, or maintained at, a microtubule." [GOC:bf, GOC:lb]
synonym: "protein localisation to microtubule" EXACT [GOC:mah]
is_a: GO:0072698 ! protein localization to microtubule cytoskeleton
created_by: rfoulger
creation_date: 2010-03-11T11:00:56Z

[Term]
id: GO:0035373
name: chondroitin sulfate proteoglycan binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a chondroitin sulfate proteoglycan, any proteoglycan containing chondroitin sulfate as the glycosaminoglycan carbohydrate unit." [GOC:kmv, ISBN:0198506732]
is_a: GO:0005539 ! glycosaminoglycan binding
is_a: GO:0043168 ! anion binding
is_a: GO:0043394 ! proteoglycan binding
is_a: GO:1901681 ! sulfur compound binding
created_by: rfoulger
creation_date: 2010-03-12T10:23:55Z

[Term]
id: GO:0035374
name: chondroitin sulfate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with chondroitin sulfate, a glycosaminoglycan made up of two alternating monosaccharides: D-glucuronic acid (GlcA) and N-acetyl-D-galactosamine (GalNAc)." [GOC:kmv, ISBN:0198506732]
is_a: GO:0005539 ! glycosaminoglycan binding
is_a: GO:0043168 ! anion binding
is_a: GO:1901681 ! sulfur compound binding
created_by: rfoulger
creation_date: 2010-03-12T10:25:34Z

[Term]
id: GO:0035375
name: zymogen binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a zymogen, an enzymatically inactive precursor of an enzyme that is often convertible to an active enzyme by proteolysis." [ISBN:0198506732]
synonym: "proenzyme binding" NARROW [ISBN:0198506732]
is_a: GO:0019899 ! enzyme binding
created_by: rfoulger
creation_date: 2010-03-18T10:50:35Z

[Term]
id: GO:0035376
name: sterol import
namespace: biological_process
def: "The directed movement of a sterol into a cell or organelle. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:bf, PMID:19793923]
synonym: "sterol influx" EXACT [PMID:12077145]
synonym: "sterol uptake" EXACT [PMID:12077145]
is_a: GO:0015918 ! sterol transport
created_by: rfoulger
creation_date: 2010-03-18T10:53:01Z

[Term]
id: GO:0035377
name: transepithelial water transport
namespace: biological_process
def: "The directed movement of water (H2O) from one side of an epithelium to the other." [GOC:yaf]
is_a: GO:0006833 ! water transport
is_a: GO:0042045 ! epithelial fluid transport
is_a: GO:0070633 ! transepithelial transport
created_by: rfoulger
creation_date: 2010-03-18T10:55:38Z

[Term]
id: GO:0035378
name: carbon dioxide transmembrane transport
namespace: biological_process
def: "A process in which carbon dioxide (CO2) is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:yaf]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "carbon dioxide membrane transport" EXACT []
is_a: GO:0015670 ! carbon dioxide transport
is_a: GO:0055085 ! transmembrane transport
created_by: rfoulger
creation_date: 2010-03-18T11:17:54Z

[Term]
id: GO:0035379
name: carbon dioxide transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of carbon dioxide (CO2) from one side of a membrane to the other." [GOC:yaf]
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity
relationship: part_of GO:0035378 ! carbon dioxide transmembrane transport
created_by: rfoulger
creation_date: 2010-03-18T11:19:38Z

[Term]
id: GO:0035380
name: very long-chain-3-hydroxyacyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD(P)+ = 3-oxoacyl-CoA + NAD(P)H + H+, where the acyl group is a very long-chain fatty acid residue. A very long-chain fatty acid is a fatty acid which has a chain length greater than C22." [CHEBI:27283, GOC:pde]
synonym: "very-long-chain-3-hydroxyacyl-CoA dehydrogenase activity" EXACT []
xref: EC:1.1.1.-
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
created_by: rfoulger
creation_date: 2010-03-18T11:23:05Z

[Term]
id: GO:0035381
name: ATP-gated ion channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of an ion by a channel that opens when ATP has been bound by the channel complex or one of its constituent parts." [GOC:bf]
is_a: GO:0015276 ! ligand-gated ion channel activity
created_by: rfoulger
creation_date: 2010-03-18T01:21:45Z

[Term]
id: GO:0035382
name: sterol transmembrane transport
namespace: biological_process
def: "The directed movement of a sterol across a membrane into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:vw]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "sterol membrane transport" EXACT []
is_a: GO:0015918 ! sterol transport
is_a: GO:0055085 ! transmembrane transport
created_by: rfoulger
creation_date: 2010-03-18T01:24:39Z

[Term]
id: GO:0035383
name: thioester metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a thioester, a compound of general formula RC(=O)SR' in which the linking oxygen in an ester is replaced by a sulfur atom. They are the product of esterification between a carboxylic acid and a thiol." [CHEBI:51277, GOC:bf, http://encyclopedia.thefreedictionary.com/Thioester]
synonym: "thioester metabolism" EXACT []
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0071704 ! organic substance metabolic process
created_by: rfoulger
creation_date: 2010-03-18T01:48:12Z

[Term]
id: GO:0035384
name: thioester biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a thioester, a compound of general formula RC(=O)SR' in which the linking oxygen in an ester is replaced by a sulfur atom. They are the product of esterification between a carboxylic acid and a thiol." [CHEBI:51277, GOC:bf, http://encyclopedia.thefreedictionary.com/Thioester]
synonym: "thioester anabolism" EXACT []
synonym: "thioester biosynthesis" EXACT []
synonym: "thioester formation" EXACT []
synonym: "thioester synthesis" EXACT []
is_a: GO:0035383 ! thioester metabolic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:1901576 ! organic substance biosynthetic process
created_by: rfoulger
creation_date: 2010-03-18T01:52:11Z

[Term]
id: GO:0035385
name: Roundabout signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of a SLIT protein to a Roundabout (ROBO) family receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:signaling]
synonym: "ROBO signaling pathway" EXACT []
synonym: "ROBO/SLIT signaling pathway" EXACT []
synonym: "Roundabout signalling pathway" EXACT [GOC:mah]
is_a: GO:0007166 ! cell surface receptor signaling pathway
created_by: rfoulger
creation_date: 2010-03-18T02:38:31Z

[Term]
id: GO:0035386
name: regulation of Roundabout signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the Roundabout signaling pathway." [GOC:BHF]
synonym: "regulation of Roundabout signalling pathway" EXACT [GOC:mah]
is_a: GO:0009966 ! regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035385 ! Roundabout signaling pathway
relationship: regulates GO:0035385 ! Roundabout signaling pathway
created_by: rfoulger
creation_date: 2010-03-18T02:39:24Z

[Term]
id: GO:0035387
name: negative regulation of Roundabout signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the Roundabout signaling pathway." [GOC:BHF]
synonym: "negative regulation of Roundabout signalling pathway" EXACT [GOC:mah]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0035386 ! regulation of Roundabout signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035385 ! Roundabout signaling pathway
relationship: negatively_regulates GO:0035385 ! Roundabout signaling pathway
created_by: rfoulger
creation_date: 2010-03-18T02:40:00Z

[Term]
id: GO:0035388
name: positive regulation of Roundabout signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the Roundabout signaling pathway." [GOC:BHF]
synonym: "positive regulation of Roundabout signalling pathway" EXACT [GOC:mah]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0035386 ! regulation of Roundabout signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035385 ! Roundabout signaling pathway
relationship: positively_regulates GO:0035385 ! Roundabout signaling pathway
created_by: rfoulger
creation_date: 2010-03-18T02:41:16Z

[Term]
id: GO:0035389
name: establishment of chromatin silencing at silent mating-type cassette
namespace: biological_process
def: "The initial formation of a transcriptionally silent chromatin structure such as heterochromatin at silent mating-type loci." [GOC:vw]
is_a: GO:0006343 ! establishment of chromatin silencing
relationship: part_of GO:0030466 ! chromatin silencing at silent mating-type cassette
created_by: rfoulger
creation_date: 2010-03-22T10:23:14Z

[Term]
id: GO:0035390
name: establishment of chromatin silencing at telomere
namespace: biological_process
def: "The initial formation of a transcriptionally silent chromatin structure such as heterochromatin at the telomere." [GOC:vw]
is_a: GO:0006343 ! establishment of chromatin silencing
relationship: part_of GO:0006348 ! chromatin silencing at telomere
created_by: rfoulger
creation_date: 2010-03-22T10:24:07Z

[Term]
id: GO:0035391
name: maintenance of chromatin silencing at silent mating-type cassette
namespace: biological_process
def: "The maintenance of chromatin in a transcriptionally silent state such as heterochromatin at silent mating-type loci." [GOC:vw]
is_a: GO:0006344 ! maintenance of chromatin silencing
relationship: part_of GO:0030466 ! chromatin silencing at silent mating-type cassette
created_by: rfoulger
creation_date: 2010-03-22T10:25:14Z

[Term]
id: GO:0035392
name: maintenance of chromatin silencing at telomere
namespace: biological_process
def: "The maintenance of chromatin in a transcriptionally silent state such as heterochromatin at the telomere." [GOC:vw]
is_a: GO:0006344 ! maintenance of chromatin silencing
relationship: part_of GO:0006348 ! chromatin silencing at telomere
created_by: rfoulger
creation_date: 2010-03-22T10:25:57Z

[Term]
id: GO:0035393
name: chemokine (C-X-C motif) ligand 9 production
namespace: biological_process
def: "The appearance of chemokine (C-X-C motif) ligand 9 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add]
synonym: "CXCL9 production" EXACT []
synonym: "MIG production" EXACT []
synonym: "Monokine induced by gamma interferon production" EXACT []
is_a: GO:0032602 ! chemokine production
created_by: rfoulger
creation_date: 2010-03-23T10:03:20Z

[Term]
id: GO:0035394
name: regulation of chemokine (C-X-C motif) ligand 9 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of chemokine (C-X-C motif) ligand 9." [GOC:bf]
synonym: "regulation of CXCL9 production" EXACT []
synonym: "regulation of MIG production" EXACT []
is_a: GO:0032642 ! regulation of chemokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035393 ! chemokine (C-X-C motif) ligand 9 production
relationship: regulates GO:0035393 ! chemokine (C-X-C motif) ligand 9 production
created_by: rfoulger
creation_date: 2010-03-23T10:06:19Z

[Term]
id: GO:0035395
name: negative regulation of chemokine (C-X-C motif) ligand 9 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-X-C motif) ligand 9." [GOC:bf]
synonym: "negative regulation of CXCL9 production" EXACT []
synonym: "negative regulation of MIG production" EXACT []
is_a: GO:0032682 ! negative regulation of chemokine production
is_a: GO:0035394 ! regulation of chemokine (C-X-C motif) ligand 9 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035393 ! chemokine (C-X-C motif) ligand 9 production
relationship: negatively_regulates GO:0035393 ! chemokine (C-X-C motif) ligand 9 production
created_by: rfoulger
creation_date: 2010-03-23T10:06:44Z

[Term]
id: GO:0035396
name: positive regulation of chemokine (C-X-C motif) ligand 9 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-X-C motif) ligand 9." [GOC:bf]
synonym: "positive regulation of CXCL9 production" EXACT []
synonym: "positive regulation of MIG production" EXACT []
is_a: GO:0032722 ! positive regulation of chemokine production
is_a: GO:0035394 ! regulation of chemokine (C-X-C motif) ligand 9 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035393 ! chemokine (C-X-C motif) ligand 9 production
relationship: positively_regulates GO:0035393 ! chemokine (C-X-C motif) ligand 9 production
created_by: rfoulger
creation_date: 2010-03-23T10:07:17Z

[Term]
id: GO:0035397
name: helper T cell enhancement of adaptive immune response
namespace: biological_process
def: "Positive regulation of an adaptive immune response mediated via cytokine production by helper T cell." [GOC:add]
synonym: "provision of T cell help" EXACT []
is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
created_by: rfoulger
creation_date: 2010-03-23T10:38:31Z

[Term]
id: GO:0035398
name: helper T cell enhancement of T cell mediated immune response
namespace: biological_process
def: "Positive regulation of a T cell mediated immune response mediated via cytokine production by a helper T cell." [GOC:add]
synonym: "helper T cell enhancement of T cell mediated immunity" EXACT []
synonym: "provision of T cell help to T cell" EXACT []
is_a: GO:0002711 ! positive regulation of T cell mediated immunity
is_a: GO:0035397 ! helper T cell enhancement of adaptive immune response
created_by: rfoulger
creation_date: 2010-03-23T10:40:00Z

[Term]
id: GO:0035399
name: helper T cell enhancement of B cell mediated immune response
namespace: biological_process
def: "Positive regulation of a B cell mediated immune response mediated via cytokine production by a helper T cell." [GOC:add]
synonym: "helper T cell enhancement of B cell mediated immunity" EXACT []
synonym: "provision of T cell help to B cell" EXACT []
is_a: GO:0002714 ! positive regulation of B cell mediated immunity
is_a: GO:0035397 ! helper T cell enhancement of adaptive immune response
created_by: rfoulger
creation_date: 2010-03-23T10:41:46Z

[Term]
id: GO:0035400
name: histone tyrosine kinase activity
namespace: molecular_function
def: "Catalysis of the transfer of a phosphate group to a tyrosine residue of a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes." [GOC:bf]
synonym: "histone-tyrosine kinase activity" EXACT []
is_a: GO:0004713 ! protein tyrosine kinase activity
is_a: GO:0035173 ! histone kinase activity
relationship: part_of GO:0035406 ! histone-tyrosine phosphorylation
created_by: rfoulger
creation_date: 2010-03-24T09:59:15Z

[Term]
id: GO:0035401
name: histone kinase activity (H3-Y41 specific)
namespace: molecular_function
def: "The modification of histone H3 by the addition of a phosphate group to a tyrosine residue at position 41 of the histone." [GOC:bf]
synonym: "histone tyrosine kinase activity (H3-Y41 specific)" EXACT []
synonym: "histone-tyrosine kinase activity (H3-Y41 specific)" EXACT []
is_a: GO:0035400 ! histone tyrosine kinase activity
relationship: part_of GO:0035409 ! histone H3-Y41 phosphorylation
created_by: rfoulger
creation_date: 2010-03-24T10:01:14Z

[Term]
id: GO:0035402
name: histone kinase activity (H3-T11 specific)
namespace: molecular_function
def: "Catalysis of the transfer of a phosphate group to the threonine-11 residue of the N-terminal tail of histone H3." [GOC:bf]
synonym: "histone threonine kinase activity (H3-T11 specific)" EXACT []
synonym: "histone-threonine kinase activity (H3-T11 specific)" EXACT []
is_a: GO:0035184 ! histone threonine kinase activity
relationship: part_of GO:0035407 ! histone H3-T11 phosphorylation
created_by: rfoulger
creation_date: 2010-03-24T10:04:40Z

[Term]
id: GO:0035403
name: histone kinase activity (H3-T6 specific)
namespace: molecular_function
def: "Catalysis of the transfer of a phosphate group to the threonine-6 residue of the N-terminal tail of histone H3." [GOC:bf]
synonym: "histone threonine kinase activity (H3-T6 specific)" EXACT []
synonym: "histone-threonine kinase activity (H3-T6 specific)" EXACT []
is_a: GO:0035184 ! histone threonine kinase activity
relationship: part_of GO:0035408 ! histone H3-T6 phosphorylation
created_by: rfoulger
creation_date: 2010-03-24T10:05:39Z

[Term]
id: GO:0035404
name: histone-serine phosphorylation
namespace: biological_process
def: "The modification of histones by addition of a phosphate group to a serine residue." [GOC:bf]
synonym: "histone serine phosphorylation" EXACT []
is_a: GO:0016572 ! histone phosphorylation
is_a: GO:0018105 ! peptidyl-serine phosphorylation
created_by: rfoulger
creation_date: 2010-03-24T10:08:25Z

[Term]
id: GO:0035405
name: histone-threonine phosphorylation
namespace: biological_process
def: "The modification of histones by addition of a phosphate group to a threonine residue." [GOC:bf]
synonym: "histone threonine phosphorylation" EXACT []
is_a: GO:0016572 ! histone phosphorylation
is_a: GO:0018107 ! peptidyl-threonine phosphorylation
created_by: rfoulger
creation_date: 2010-03-24T10:09:21Z

[Term]
id: GO:0035406
name: histone-tyrosine phosphorylation
namespace: biological_process
def: "The modification of histones by addition of a phosphate group to a tyrosine residue." [GOC:bf]
synonym: "histone tyrosine phosphorylation" EXACT []
is_a: GO:0016572 ! histone phosphorylation
is_a: GO:0018108 ! peptidyl-tyrosine phosphorylation
created_by: rfoulger
creation_date: 2010-03-24T10:10:16Z

[Term]
id: GO:0035407
name: histone H3-T11 phosphorylation
namespace: biological_process
def: "The modification of histone H3 by the addition of an phosphate group to a threonine residue at position 11 of the histone." [GOC:bf]
is_a: GO:0035405 ! histone-threonine phosphorylation
created_by: rfoulger
creation_date: 2010-03-24T10:12:01Z

[Term]
id: GO:0035408
name: histone H3-T6 phosphorylation
namespace: biological_process
def: "The modification of histone H3 by the addition of an phosphate group to a threonine residue at position 6 of the histone." [GOC:bf]
is_a: GO:0035405 ! histone-threonine phosphorylation
created_by: rfoulger
creation_date: 2010-03-24T10:12:51Z

[Term]
id: GO:0035409
name: histone H3-Y41 phosphorylation
namespace: biological_process
def: "The modification of histone H3 by the addition of a phosphate group to a tyrosine residue at position 41 of the histone." [GOC:bf]
is_a: GO:0035406 ! histone-tyrosine phosphorylation
created_by: rfoulger
creation_date: 2010-03-24T10:13:13Z

[Term]
id: GO:0035410
name: dihydrotestosterone 17-beta-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5alpha-dihydrotestosterone + NAD+ = 5alpha-androstane-3,17-dione + NADH." [GOC:ecd, http://www.brenda-enzymes.org/php/result_flat.php4?ecno=1.1.1.63, PMID:4152755]
xref: EC:1.1.1.-
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
created_by: rfoulger
creation_date: 2010-03-24T10:48:41Z

[Term]
id: GO:0035411
name: catenin import into nucleus
namespace: biological_process
def: "The directed movement of a catenin protein from the cytoplasm into the nucleus." [GOC:BHF]
comment: Note that 'translocation' is sometimes used in the literature to refer to the entire process of protein import into the nucleus, but in GO refers specifically to the step in which a cargo-carrier protein complex moves through the nuclear pore complex.
synonym: "catenin protein nuclear translocation" NARROW [GOC:mah]
is_a: GO:0006606 ! protein import into nucleus
created_by: rfoulger
creation_date: 2010-03-24T02:51:42Z

[Term]
id: GO:0035412
name: regulation of catenin import into nucleus
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the directed movement of a catenin protein from the cytoplasm into the nucleus." [GOC:BHF]
synonym: "regulation of catenin protein nuclear translocation" NARROW [GOC:mah]
is_a: GO:0042306 ! regulation of protein import into nucleus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035411 ! catenin import into nucleus
relationship: regulates GO:0035411 ! catenin import into nucleus
created_by: rfoulger
creation_date: 2010-03-24T02:52:33Z

[Term]
id: GO:0035413
name: positive regulation of catenin import into nucleus
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the directed movement of a catenin protein from the cytoplasm into the nucleus." [GOC:BHF]
synonym: "positive regulation of catenin protein nuclear translocation" NARROW [GOC:mah]
is_a: GO:0035412 ! regulation of catenin import into nucleus
is_a: GO:0042307 ! positive regulation of protein import into nucleus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035411 ! catenin import into nucleus
relationship: positively_regulates GO:0035411 ! catenin import into nucleus
created_by: rfoulger
creation_date: 2010-03-24T02:53:38Z

[Term]
id: GO:0035414
name: negative regulation of catenin import into nucleus
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the directed movement of a catenin protein from the cytoplasm into the nucleus." [GOC:BHF]
synonym: "negative regulation of catenin protein nuclear translocation" NARROW [GOC:mah]
is_a: GO:0035412 ! regulation of catenin import into nucleus
is_a: GO:0042308 ! negative regulation of protein import into nucleus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035411 ! catenin import into nucleus
relationship: negatively_regulates GO:0035411 ! catenin import into nucleus
created_by: rfoulger
creation_date: 2010-03-24T02:54:21Z

[Term]
id: GO:0035415
name: obsolete regulation of mitotic prometaphase
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of mitotic prometaphase, the stage following prophase in mitosis (in higher eukaryotes) during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region." [GOC:bf]
comment: This term was made obsolete as part of the cell cycle overhaul. This is because it was decided that cell cycle phases are intervals and so cannot be regulated, rather it is the transitions between the phases that are regulated.
synonym: "regulation of mitotic prometaphase" EXACT []
is_obsolete: true
created_by: rfoulger
creation_date: 2010-03-29T10:52:08Z

[Term]
id: GO:0035416
name: obsolete positive regulation of mitotic prometaphase
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of mitotic prometaphase, the stage following prophase in mitosis (in higher eukaryotes) during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region." [GOC:bf]
comment: This term was made obsolete as part of the cell cycle overhaul. This is because it was decided that cell cycle phases are intervals and so cannot be regulated, rather it is the transitions between the phases that are regulated.
synonym: "positive regulation of mitotic prometaphase" EXACT []
is_obsolete: true
created_by: rfoulger
creation_date: 2010-03-29T10:52:55Z

[Term]
id: GO:0035417
name: obsolete negative regulation of mitotic prometaphase
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the rate or extent of mitotic prometaphase, the stage following prophase in mitosis (in higher eukaryotes) during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region." [GOC:bf]
comment: This term was made obsolete as part of the cell cycle overhaul. This is because it was decided that cell cycle phases are intervals and so cannot be regulated, rather it is the transitions between the phases that are regulated.
synonym: "negative regulation of mitotic prometaphase" EXACT []
is_obsolete: true
created_by: rfoulger
creation_date: 2010-03-29T10:53:42Z

[Term]
id: GO:0035418
name: protein localization to synapse
namespace: biological_process
def: "Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." [GOC:bf]
synonym: "protein localisation to synapse" EXACT [GOC:mah]
is_a: GO:0008104 ! protein localization
created_by: rfoulger
creation_date: 2010-03-29T10:58:53Z

[Term]
id: GO:0035419
name: activation of MAPK activity involved in innate immune response
namespace: biological_process
def: "Any process that initiates the activity of the inactive enzyme MAP kinase in the context of an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens." [GOC:bf]
xref: Reactome:REACT_24954 "NFkB and MAPK activation mediated by TRAF6, Gallus gallus"
xref: Reactome:REACT_27197 "NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation, Gallus gallus"
is_a: GO:0000187 ! activation of MAPK activity
is_a: GO:0002758 ! innate immune response-activating signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0038075 ! MAP kinase activity involved in innate immune response
relationship: positively_regulates GO:0038075 ! MAP kinase activity involved in innate immune response
created_by: rfoulger
creation_date: 2010-03-29T01:25:24Z

[Term]
id: GO:0035420
name: MAPK cascade involved in innate immune response
namespace: biological_process
def: "A MAPK cascade that contributes to an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens." [GOC:bf]
synonym: "MAPKKK cascade involved in innate immune response" EXACT [GOC:signaling]
is_a: GO:0000165 ! MAPK cascade
intersection_of: GO:0000165 ! MAPK cascade
intersection_of: part_of GO:0045087 ! innate immune response
relationship: part_of GO:0045087 ! innate immune response
created_by: rfoulger
creation_date: 2010-03-29T01:25:59Z

[Term]
id: GO:0035421
name: activation of MAPKK activity involved in innate immune response
namespace: biological_process
def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase in the context of an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens." [GOC:bf]
is_a: GO:0000186 ! activation of MAPKK activity
is_a: GO:0002758 ! innate immune response-activating signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0038076 ! MAP kinase kinase activity involved in innate immune response
relationship: positively_regulates GO:0038076 ! MAP kinase kinase activity involved in innate immune response
created_by: rfoulger
creation_date: 2010-03-29T01:26:44Z

[Term]
id: GO:0035422
name: activation of MAPKKK activity involved in innate immune response
namespace: biological_process
def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase in the context of an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens." [GOC:bf]
is_a: GO:0000185 ! activation of MAPKKK activity
is_a: GO:0002758 ! innate immune response-activating signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0038077 ! MAP kinase kinase kinase activity involved in innate immune response
relationship: positively_regulates GO:0038077 ! MAP kinase kinase kinase activity involved in innate immune response
created_by: rfoulger
creation_date: 2010-03-29T01:27:38Z

[Term]
id: GO:0035423
name: inactivation of MAPK activity involved in innate immune response
namespace: biological_process
def: "Any process that terminates the activity of the active enzyme MAP kinase in the context of an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens." [GOC:bf]
is_a: GO:0000188 ! inactivation of MAPK activity
is_a: GO:0002766 ! innate immune response-inhibiting signal transduction
is_a: GO:0045824 ! negative regulation of innate immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0038075 ! MAP kinase activity involved in innate immune response
relationship: negatively_regulates GO:0038075 ! MAP kinase activity involved in innate immune response
created_by: rfoulger
creation_date: 2010-03-29T01:28:59Z

[Term]
id: GO:0035424
name: MAPK import into nucleus involved in innate immune response
namespace: biological_process
def: "The directed movement of a MAP kinase to the nucleus in the context of an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens." [GOC:bf]
synonym: "nuclear translocation of MAPK involved in innate immune response" NARROW [GOC:mah]
is_a: GO:0000189 ! MAPK import into nucleus
is_a: GO:0002758 ! innate immune response-activating signal transduction
is_a: GO:0035556 ! intracellular signal transduction
is_a: GO:0044763 ! single-organism cellular process
intersection_of: GO:0000189 ! MAPK import into nucleus
intersection_of: part_of GO:0045087 ! innate immune response
relationship: part_of GO:0035420 ! MAPK cascade involved in innate immune response
relationship: part_of GO:0045087 ! innate immune response
created_by: rfoulger
creation_date: 2010-03-29T01:29:36Z

[Term]
id: GO:0035425
name: autocrine signaling
namespace: biological_process
def: "Signaling between cells of the same type. The signal produced by the signaling cell binds to a receptor on, and affects a cell of the same type." [GOC:bf, ISBN:3527303782]
synonym: "autocrine signalling" EXACT [GOC:mah]
is_a: GO:0007267 ! cell-cell signaling
created_by: rfoulger
creation_date: 2010-03-29T02:15:52Z

[Term]
id: GO:0035426
name: extracellular matrix-cell signaling
namespace: biological_process
def: "Any process that mediates the transfer of information between the extracellular matrix and a cell." [GOC:bf]
synonym: "cell-extracellular matrix signalling" EXACT []
synonym: "extracellular matrix-cell signalling" EXACT []
is_a: GO:0007154 ! cell communication
is_a: GO:0044700 ! single organism signaling
created_by: rfoulger
creation_date: 2010-03-29T02:26:54Z

[Term]
id: GO:0035428
name: hexose transmembrane transport
namespace: biological_process
def: "The directed movement of hexose across a membrane by means of some agent such as a transporter or pore. Hexoses are any aldoses with a chain of six carbon atoms in the molecule." [GOC:vw]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "hexose membrane transport" EXACT []
is_a: GO:0008645 ! hexose transport
is_a: GO:0034219 ! carbohydrate transmembrane transport
created_by: rfoulger
creation_date: 2010-04-08T10:27:23Z

[Term]
id: GO:0035429
name: gluconate transmembrane transport
namespace: biological_process
def: "The directed movement of gluconate across a membrane by means of some agent such as a transporter or pore. Gluconate is the aldonic acid derived from glucose." [GOC:vw, ISBN:0198506732]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "gluconate membrane transport" EXACT []
is_a: GO:0015725 ! gluconate transport
is_a: GO:0034219 ! carbohydrate transmembrane transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport
created_by: rfoulger
creation_date: 2010-04-08T10:33:46Z

[Term]
id: GO:0035430
name: regulation of gluconate transmembrane transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a gluconate across a membrane by means of some agent such as a transporter or pore." [GOC:vw]
synonym: "regulation of gluconate membrane transport" EXACT []
is_a: GO:0032893 ! regulation of gluconate transport
is_a: GO:1903959 ! regulation of anion transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035429 ! gluconate transmembrane transport
relationship: regulates GO:0035429 ! gluconate transmembrane transport
created_by: rfoulger
creation_date: 2010-04-08T10:37:18Z

[Term]
id: GO:0035431
name: negative regulation of gluconate transmembrane transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of gluconate across a membrane by means of some agent such as a transporter or pore." [GOC:vw]
synonym: "negative regulation of gluconate membrane transport" EXACT []
is_a: GO:0032894 ! negative regulation of gluconate transport
is_a: GO:0035430 ! regulation of gluconate transmembrane transport
is_a: GO:1903960 ! negative regulation of anion transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035429 ! gluconate transmembrane transport
relationship: negatively_regulates GO:0035429 ! gluconate transmembrane transport
created_by: rfoulger
creation_date: 2010-04-08T10:39:08Z

[Term]
id: GO:0035432
name: positive regulation of gluconate transmembrane transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of gluconate across a membrane by means of some agent such as a transporter or pore." [GOC:vw]
synonym: "positive regulation of gluconate membrane transport" EXACT []
is_a: GO:0032895 ! positive regulation of gluconate transport
is_a: GO:0035430 ! regulation of gluconate transmembrane transport
is_a: GO:1903961 ! positive regulation of anion transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035429 ! gluconate transmembrane transport
relationship: positively_regulates GO:0035429 ! gluconate transmembrane transport
created_by: rfoulger
creation_date: 2010-04-08T10:39:58Z

[Term]
id: GO:0035433
name: acetate transmembrane transport
namespace: biological_process
def: "The directed movement of acetate across a membrane by means of some agent such as a transporter or pore. Acetate is the 2-carbon carboxylic acid ethanoic acid." [GOC:vw]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "acetate membrane transport" EXACT []
is_a: GO:0006846 ! acetate transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport
created_by: rfoulger
creation_date: 2010-04-08T10:59:01Z

[Term]
id: GO:0035434
name: copper ion transmembrane transport
namespace: biological_process
alt_id: GO:1901473
def: "The directed movement of copper cation across a membrane." [GOC:vw]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "copper cation transmembrane transport" EXACT []
synonym: "copper ion membrane transport" EXACT []
is_a: GO:0006825 ! copper ion transport
is_a: GO:0098662 ! inorganic cation transmembrane transport
created_by: rfoulger
creation_date: 2010-04-08T11:03:23Z

[Term]
id: GO:0035435
name: phosphate ion transmembrane transport
namespace: biological_process
def: "The directed movement of phosphate across a membrane by means of some agent such as a transporter or pore." [GOC:vw]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "phosphate ion membrane transport" EXACT []
is_a: GO:0006817 ! phosphate ion transport
is_a: GO:0098661 ! inorganic anion transmembrane transport
created_by: rfoulger
creation_date: 2010-04-08T11:24:06Z

[Term]
id: GO:0035436
name: triose phosphate transmembrane transport
namespace: biological_process
def: "The directed movement of triose phosphate across a membrane by means of some agent such as a transporter or pore. Triose phosphate is any organic three carbon compound phosphate ester." [GOC:bf, ISBN:0198506732]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "triose phosphate membrane transport" EXACT []
is_a: GO:0015717 ! triose phosphate transport
is_a: GO:0055085 ! transmembrane transport
created_by: rfoulger
creation_date: 2010-04-08T02:54:07Z

[Term]
id: GO:0035437
name: maintenance of protein localization in endoplasmic reticulum
namespace: biological_process
def: "Any process in which a protein is maintained in the endoplasmic reticulum and prevented from moving elsewhere. These include sequestration within the endoplasmic reticulum, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the endoplasmic reticulum." [GOC:bf, GOC:vw]
synonym: "maintenance of protein localisation in endoplasmic reticulum" EXACT [GOC:mah]
synonym: "maintenance of protein localization in ER" EXACT []
synonym: "maintenance of protein location in endoplasmic reticulum" EXACT []
synonym: "maintenance of protein location in ER" EXACT []
synonym: "protein-endoplasmic reticulum retention" EXACT []
synonym: "protein-ER retention" EXACT []
synonym: "retention of protein in endoplasmic reticulum" EXACT []
synonym: "retention of protein in ER" EXACT []
is_a: GO:0051220 ! cytoplasmic sequestering of protein
is_a: GO:0072595 ! maintenance of protein localization in organelle
intersection_of: GO:0045185 ! maintenance of protein location
intersection_of: occurs_in GO:0005783 ! endoplasmic reticulum
relationship: occurs_in GO:0005783 ! endoplasmic reticulum
relationship: part_of GO:0070972 ! protein localization to endoplasmic reticulum
created_by: rfoulger
creation_date: 2010-04-09T10:39:49Z

[Term]
id: GO:0035438
name: cyclic-di-GMP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with cyclic-di-GMP, cyclic dimeric guanosine monophosphate." [CHEBI:49537, GOC:bf]
synonym: "3',5'-cyclic di-GMP binding" EXACT [CHEBI:49537]
synonym: "c-di-GMP binding" EXACT [CHEBI:49537]
synonym: "cyclic dinucleotide di-GMP binding" EXACT [CHEBI:49537]
is_a: GO:0030551 ! cyclic nucleotide binding
is_a: GO:0032561 ! guanyl ribonucleotide binding
is_a: GO:0043168 ! anion binding
created_by: rfoulger
creation_date: 2010-04-09T02:40:17Z

[Term]
id: GO:0035439
name: halimadienyl-diphosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranylgeranyl diphosphate = halima-5(6),13-dien-15-yl diphosphate." [EC:5.5.1.16]
synonym: "halima-5(6),13-dien-15-yl-diphosphate lyase (cyclizing)" EXACT [EC:5.5.1.16]
synonym: "halimadienyl diphosphate synthase activity" EXACT [EC:5.5.1.16]
xref: EC:5.5.1.16
xref: RHEA:25624
is_a: GO:0009975 ! cyclase activity
is_a: GO:0016872 ! intramolecular lyase activity
created_by: rfoulger
creation_date: 2010-04-09T02:59:35Z

[Term]
id: GO:0035440
name: tuberculosinol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tuberculosinol (halima-5,6,dien-15-ol), a secondary metabolite in Mycobacteria." [CHEBI:50387, MetaCyc:PWY-5935]
synonym: "halima-5,6,dien-15-ol biosynthesis" EXACT [CHEBI:50387]
synonym: "halima-5,6,dien-15-ol biosynthetic process" EXACT [CHEBI:50387]
synonym: "tuberculosinol biosynthesis" EXACT []
xref: MetaCyc:PWY-5935
is_a: GO:0016102 ! diterpenoid biosynthetic process
created_by: rfoulger
creation_date: 2010-04-09T03:36:19Z

[Term]
id: GO:0035441
name: cell migration involved in vasculogenesis
namespace: biological_process
def: "The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form de novo blood vessels and tubes." [GOC:dgh]
is_a: GO:0016477 ! cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: part_of GO:0001570 ! vasculogenesis
relationship: part_of GO:0001570 ! vasculogenesis
created_by: rfoulger
creation_date: 2010-04-09T03:53:01Z

[Term]
id: GO:0035442
name: dipeptide transmembrane transport
namespace: biological_process
def: "The directed movement of a dipeptide across a membrane by means of some agent such as a transporter or pore. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond." [GOC:vw]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "dipeptide membrane transport" EXACT []
is_a: GO:0035672 ! oligopeptide transmembrane transport
is_a: GO:0042938 ! dipeptide transport
created_by: rfoulger
creation_date: 2010-04-13T09:18:33Z

[Term]
id: GO:0035443
name: tripeptide transmembrane transport
namespace: biological_process
def: "The directed movement of a tripeptide across a membrane by means of some agent such as a transporter or pore. A tripeptide is a compound containing three amino acids linked together by peptide bonds." [GOC:vw]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "tripeptide membrane transport" EXACT []
is_a: GO:0035672 ! oligopeptide transmembrane transport
is_a: GO:0042939 ! tripeptide transport
created_by: rfoulger
creation_date: 2010-04-13T09:20:25Z

[Term]
id: GO:0035444
name: nickel cation transmembrane transport
namespace: biological_process
def: "The directed movement of nickel (Ni) cations across a membrane by means of some agent such as a transporter or pore." [GOC:vw]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "nickel cation membrane transport" EXACT []
is_a: GO:0015675 ! nickel cation transport
is_a: GO:0098662 ! inorganic cation transmembrane transport
created_by: rfoulger
creation_date: 2010-04-13T09:22:51Z

[Term]
id: GO:0035445
name: borate transmembrane transport
namespace: biological_process
def: "The directed movement of borate across a membrane by means of some agent such as a transporter or pore. Borate is the anion (BO3)3-; boron is a group 13 element, with properties which are borderline between metals and non-metals." [CHEBI:22908, GOC:curators]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "borate membrane transport" EXACT []
synonym: "boron transmembrane transport" RELATED [GOC:curators]
is_a: GO:0046713 ! borate transport
is_a: GO:0098661 ! inorganic anion transmembrane transport
created_by: rfoulger
creation_date: 2010-04-13T09:24:23Z

[Term]
id: GO:0035446
name: cysteine-glucosaminylinositol ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-(2-amino-2-deoxy-alpha-D-glucopyranoside)-1D-myo-inositol + L-cysteine + ATP = 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside + AMP + diphosphate + 2 H+. 1-(2-amino-2-deoxy-alpha-D-glucopyranoside)-1D-myo-inositol is also known as glucosaminyl-inositol or GlcN-Ins, and 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside as desacetylmycothiol or Cys-GlcN-Ins." [EC:6.3.1.13, MetaCyc:RXN1G-4, PMID:12033919]
synonym: "desacetylmycothiol synthase" RELATED [PMID:12033919]
synonym: "L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase" EXACT [EC:6.3.1.13]
synonym: "MshC ligase" EXACT [EC:6.3.1.13]
xref: EC:6.3.1.13
xref: MetaCyc:RXN1G-4
xref: Reactome:REACT_27279 "glucosaminyl-inositol and cysteine are ligated to desacetylmycothiol, Mycobacterium tuberculosis"
xref: RHEA:26179
is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity
created_by: rfoulger
creation_date: 2010-04-14T11:33:06Z

[Term]
id: GO:0035447
name: mycothiol synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA = mycothiol + coenzyme A + H+. Mycothiol is also known as AcCys-GlcN-Ins and 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside as Cys-GlcN-Ins or desacetylmycothiol." [MetaCyc:MONOMER-9684, PMID:12033919]
synonym: "acetyl-CoA:Cys-GlcN-Ins acetyltransferase" EXACT []
xref: MetaCyc:MONOMER-9684
xref: Reactome:REACT_27291 "desacetylmycothiol is acetylated to mycothiol using acetyl-CoA, Mycobacterium tuberculosis"
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups
created_by: rfoulger
creation_date: 2010-04-14T11:40:26Z

[Term]
id: GO:0035448
name: extrinsic component of thylakoid membrane
namespace: cellular_component
def: "The component of a thylakoid membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:bf, GOC:dos]
synonym: "extrinsic to thylakoid membrane" NARROW []
synonym: "peripheral to thylakoid membrane" EXACT []
is_a: GO:0019898 ! extrinsic component of membrane
is_a: GO:0044436 ! thylakoid part
intersection_of: GO:0019898 ! extrinsic component of membrane
intersection_of: part_of GO:0042651 ! thylakoid membrane
relationship: part_of GO:0042651 ! thylakoid membrane
created_by: rfoulger
creation_date: 2010-04-16T10:11:32Z

[Term]
id: GO:0035449
name: extrinsic component of plastid thylakoid membrane
namespace: cellular_component
def: "The component of a plastid thylakoid membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:bf, GOC:dos]
synonym: "extrinsic to plastid thylakoid membrane" NARROW []
synonym: "peripheral to plastid thylakoid membrane" EXACT []
is_a: GO:0035448 ! extrinsic component of thylakoid membrane
is_a: GO:0044435 ! plastid part
intersection_of: GO:0019898 ! extrinsic component of membrane
intersection_of: part_of GO:0055035 ! plastid thylakoid membrane
relationship: part_of GO:0055035 ! plastid thylakoid membrane
created_by: rfoulger
creation_date: 2010-04-16T10:14:24Z

[Term]
id: GO:0035450
name: extrinsic component of lumenal side of plastid thylakoid membrane
namespace: cellular_component
def: "The component of a plastid thylakoid membrane consisting of gene products and protein complexes that are loosely bound to its lumenal surface, but not integrated into the hydrophobic region." [GOC:bf, GOC:dos]
synonym: "extrinsic to lumenal leaflet of plastid thylakoid membrane" EXACT [GOC:ab]
synonym: "extrinsic to lumenal side of plastid thylakoid membrane" NARROW []
synonym: "peripheral to lumenal side of plastid thylakoid membrane" EXACT []
is_a: GO:0035449 ! extrinsic component of plastid thylakoid membrane
is_a: GO:0035453 ! extrinsic component of plastid inner membrane
intersection_of: GO:0019898 ! extrinsic component of membrane
intersection_of: part_of GO:0098570 ! stromal side of plastid inner membrane
relationship: part_of GO:0098570 ! stromal side of plastid inner membrane
created_by: rfoulger
creation_date: 2010-04-16T10:17:25Z

[Term]
id: GO:0035451
name: extrinsic component of stromal side of plastid thylakoid membrane
namespace: cellular_component
def: "The component of a plastid thylakoid membrane consisting of gene products and protein complexes that are loosely bound to its stromal surface, but not integrated into the hydrophobic region." [GOC:bf, GOC:dos]
synonym: "extrinsic to stromal leaflet of plastid thylakoid membrane" EXACT [GOC:ab]
synonym: "extrinsic to stromal side of plastid thylakoid membrane" NARROW []
synonym: "peripheral to stromal side of plastid thylakoid membrane" EXACT []
is_a: GO:0035449 ! extrinsic component of plastid thylakoid membrane
intersection_of: GO:0019898 ! extrinsic component of membrane
intersection_of: part_of GO:0098572 ! stromal side of plastid thylakoid membrane
relationship: part_of GO:0098572 ! stromal side of plastid thylakoid membrane
created_by: rfoulger
creation_date: 2010-04-16T10:18:01Z

[Term]
id: GO:0035452
name: extrinsic component of plastid membrane
namespace: cellular_component
def: "The component of a plastid membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:bf, GOC:dos]
synonym: "extrinsic to plastid membrane" NARROW []
synonym: "peripheral to plastid membrane" EXACT []
is_a: GO:0031312 ! extrinsic component of organelle membrane
is_a: GO:0044435 ! plastid part
intersection_of: GO:0019898 ! extrinsic component of membrane
intersection_of: part_of GO:0042170 ! plastid membrane
relationship: part_of GO:0042170 ! plastid membrane
created_by: rfoulger
creation_date: 2010-04-16T10:19:33Z

[Term]
id: GO:0035453
name: extrinsic component of plastid inner membrane
namespace: cellular_component
def: "The component of a plastid inner membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:bf, GOC:dos]
synonym: "extrinsic to plastid inner membrane" NARROW []
synonym: "peripheral to plastid inner membrane" EXACT []
is_a: GO:0035452 ! extrinsic component of plastid membrane
intersection_of: GO:0019898 ! extrinsic component of membrane
intersection_of: part_of GO:0009528 ! plastid inner membrane
relationship: part_of GO:0009528 ! plastid inner membrane
created_by: rfoulger
creation_date: 2010-04-16T10:21:14Z

[Term]
id: GO:0035454
name: extrinsic component of stromal side of plastid inner membrane
namespace: cellular_component
def: "The component of a plastid inner membrane consisting of gene products and protein complexes that are loosely bound to its stromal surface, but not integrated into the hydrophobic region." [GOC:bf, GOC:dos]
synonym: "extrinsic to stromal leaflet of plastid inner membrane" EXACT [GOC:ab]
synonym: "extrinsic to stromal side of plastid inner membrane" NARROW []
synonym: "peripheral to stromal side of plastid inner membrane" EXACT []
is_a: GO:0035450 ! extrinsic component of lumenal side of plastid thylakoid membrane
relationship: part_of GO:0098570 ! stromal side of plastid inner membrane
created_by: rfoulger
creation_date: 2010-04-16T10:23:12Z

[Term]
id: GO:0035455
name: response to interferon-alpha
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-alpha stimulus. Interferon-alpha is a type I interferon." [GOC:sl, PMID:11356686]
synonym: "response to interferon alfa-n1" RELATED [GOC:sl]
synonym: "response to interferon alfa-n3" RELATED [GOC:sl]
synonym: "response to leukocyte interferon" EXACT [GOC:sl]
synonym: "response to lymphoblast interferon" EXACT [GOC:sl]
synonym: "response to lymphoblastoid interferon" EXACT [GOC:sl]
is_a: GO:0034097 ! response to cytokine
created_by: rfoulger
creation_date: 2010-04-16T10:57:16Z

[Term]
id: GO:0035456
name: response to interferon-beta
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon." [GOC:sl, PMID:9561374, PR:000008924]
synonym: "response to beta-1 interferon" RELATED [GOC:sl]
synonym: "response to fiblaferon" EXACT [GOC:sl]
synonym: "response to fibroblast interferon" EXACT [GOC:sl]
synonym: "response to interferon beta" EXACT [GOC:hp, PR:000008924]
is_a: GO:0034097 ! response to cytokine
created_by: rfoulger
creation_date: 2010-04-16T11:06:12Z

[Term]
id: GO:0035457
name: cellular response to interferon-alpha
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-alpha stimulus. Interferon-alpha is a type I interferon." [GOC:sl, PR:000024938]
synonym: "cellular response to interferon alfa-n1" RELATED [GOC:sl]
synonym: "cellular response to interferon alfa-n3" RELATED [GOC:sl]
synonym: "cellular response to leukocyte interferon" EXACT [GOC:sl]
synonym: "cellular response to lymphoblast interferon" EXACT [GOC:sl]
synonym: "cellular response to lymphoblastoid interferon" EXACT [GOC:sl]
is_a: GO:0035455 ! response to interferon-alpha
is_a: GO:0071345 ! cellular response to cytokine stimulus
created_by: rfoulger
creation_date: 2010-04-16T11:08:29Z

[Term]
id: GO:0035458
name: cellular response to interferon-beta
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon." [GOC:sl, PR:000024939]
synonym: "cellular response to beta-1 interferon" RELATED [GOC:sl]
synonym: "cellular response to fiblaferon" EXACT [GOC:sl]
synonym: "cellular response to fibroblast interferon" EXACT [GOC:sl]
is_a: GO:0035456 ! response to interferon-beta
is_a: GO:0071345 ! cellular response to cytokine stimulus
created_by: rfoulger
creation_date: 2010-04-16T11:10:40Z

[Term]
id: GO:0035459
name: cargo loading into vesicle
namespace: biological_process
def: "The formation of a protein complex between the coat proteins and proteins that are going to be transported by a vesicle." [GOC:bf]
synonym: "cargo selection" EXACT [GOC:vw]
is_a: GO:0043623 ! cellular protein complex assembly
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0044765 ! single-organism transport
relationship: part_of GO:0016192 ! vesicle-mediated transport
created_by: rfoulger
creation_date: 2010-04-16T01:14:06Z

[Term]
id: GO:0035460
name: L-ascorbate 6-phosphate lactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-ascorbate 6-phosphate + H2O = 3-keto-L-gulonate 6-phosphate." [PMID:18097099, PMID:20359483]
xref: EC:3.1.1.-
xref: RHEA:28806
is_a: GO:0052689 ! carboxylic ester hydrolase activity
created_by: rfoulger
creation_date: 2010-04-16T02:05:41Z

[Term]
id: GO:0035461
name: vitamin transmembrane transport
namespace: biological_process
def: "The process in which a vitamin is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:bf]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "vitamin membrane transport" EXACT []
is_a: GO:0051180 ! vitamin transport
is_a: GO:0055085 ! transmembrane transport
created_by: rfoulger
creation_date: 2010-04-19T10:21:41Z

[Term]
id: GO:0035462
name: determination of left/right asymmetry in diencephalon
namespace: biological_process
def: "The establishment of the diencephalon with respect to the left and right halves." [GOC:dgh, PMID:15084459]
is_a: GO:0035545 ! determination of left/right asymmetry in nervous system
relationship: part_of GO:0021536 ! diencephalon development
created_by: rfoulger
creation_date: 2010-04-19T11:50:11Z

[Term]
id: GO:0035463
name: transforming growth factor beta receptor signaling pathway involved in determination of left/right asymmetry
namespace: biological_process
def: "A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, which contributes to determination of organismal asymmetry with respect to the left and right halves." [GOC:dgh, GOC:signaling]
synonym: "TGF-beta receptor signaling pathway involved in determination of left/right asymmetry" EXACT []
synonym: "TGF-beta receptor signalling pathway involved in determination of left/right asymmetry" EXACT []
synonym: "TGFbeta receptor signaling pathway involved in determination of left/right asymmetry" EXACT []
synonym: "TGFbeta receptor signalling pathway involved in determination of left/right asymmetry" EXACT []
synonym: "transforming growth factor beta receptor signalling pathway involved in determination of left/right asymmetry" EXACT []
is_a: GO:0007179 ! transforming growth factor beta receptor signaling pathway
intersection_of: GO:0007179 ! transforming growth factor beta receptor signaling pathway
intersection_of: part_of GO:0007368 ! determination of left/right symmetry
relationship: part_of GO:0007368 ! determination of left/right symmetry
created_by: rfoulger
creation_date: 2010-04-19T01:19:20Z

[Term]
id: GO:0035464
name: regulation of transforming growth factor receptor beta signaling pathway involved in determination of left/right asymmetry
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway that is involved in the determination of organismal asymmetry with regard to its left and right halves." [GOC:dgh]
synonym: "regulation of TGF-beta receptor signaling pathway involved in determination of left/right asymmetry" EXACT []
synonym: "regulation of TGF-beta receptor signalling pathway involved in determination of left/right asymmetry" EXACT []
synonym: "regulation of TGFbeta receptor signaling pathway involved in determination of left/right asymmetry" EXACT []
synonym: "regulation of TGFbeta receptor signalling pathway involved in determination of left/right asymmetry" EXACT []
synonym: "regulation of transforming growth factor beta receptor signalling pathway involved in determination of left/right asymmetry" EXACT []
is_a: GO:0017015 ! regulation of transforming growth factor beta receptor signaling pathway
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035463 ! transforming growth factor beta receptor signaling pathway involved in determination of left/right asymmetry
relationship: regulates GO:0035463 ! transforming growth factor beta receptor signaling pathway involved in determination of left/right asymmetry
created_by: rfoulger
creation_date: 2010-04-19T01:31:56Z

[Term]
id: GO:0035465
name: obsolete regulation of transforming growth factor beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway that is involved in the determination of the lateral plate mesoderm with respect to its left and right halves." [GOC:dgh, PMID:15084459]
comment: This term was made obsolete because it describes regulation of the nodal signaling pathway. Nodal proteins are members of the TGF-beta superfamily, but are distinct from TGF-beta proteins themselves. TGF-beta proteins are not currently known to regulate left/right asymmetry in the lateral mesoderm.
synonym: "regulation of TGF-beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT []
synonym: "regulation of TGF-beta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT []
synonym: "regulation of TGFbeta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT []
synonym: "regulation of TGFbeta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT []
synonym: "regulation of transforming growth factor beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT []
synonym: "regulation of transforming growth factor beta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT []
is_obsolete: true
replaced_by: GO:1900175
created_by: rfoulger
creation_date: 2010-04-19T01:36:23Z

[Term]
id: GO:0035469
name: determination of pancreatic left/right asymmetry
namespace: biological_process
def: "Determination of the asymmetric location of the pancreas with respect to the left and right halves of the organism." [GOC:dgh, PMID:12702646]
is_a: GO:0007368 ! determination of left/right symmetry
relationship: part_of GO:0031016 ! pancreas development
created_by: rfoulger
creation_date: 2010-04-22T10:47:15Z

[Term]
id: GO:0035470
name: positive regulation of vascular wound healing
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature." [GOC:rph]
is_a: GO:0045766 ! positive regulation of angiogenesis
is_a: GO:0061043 ! regulation of vascular wound healing
is_a: GO:0090303 ! positive regulation of wound healing
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061042 ! vascular wound healing
relationship: positively_regulates GO:0061042 ! vascular wound healing
created_by: rfoulger
creation_date: 2010-04-22T10:49:09Z

[Term]
id: GO:0035471
name: luteinizing hormone signaling pathway involved in ovarian follicle development
namespace: biological_process
def: "The series of molecular signals initiated by luteinizing hormone binding to a receptor, where the activated receptor signals via downstream effectors that contribute to progression of the ovarian follicle over time, from its formation to the mature structure." [GOC:bf]
synonym: "luteinizing hormone signalling pathway involved in ovarian follicle development" EXACT [GOC:mah]
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0022602 ! ovulation cycle process
is_a: GO:0042700 ! luteinizing hormone signaling pathway
intersection_of: GO:0042700 ! luteinizing hormone signaling pathway
intersection_of: part_of GO:0001541 ! ovarian follicle development
relationship: part_of GO:0001541 ! ovarian follicle development
created_by: rfoulger
creation_date: 2010-04-22T04:43:20Z

[Term]
id: GO:0035472
name: choriogonadotropin hormone receptor activity
namespace: molecular_function
def: "Combining with the choriogonadotropin hormone to initiate a change in cell activity." [GOC:bf, ISBN:0198506732, PMID:1922095]
synonym: "CG receptor activity" EXACT [ISBN:0198506732]
synonym: "chorio-gonadotrophin receptor activity" EXACT [ISBN:0198506732]
synonym: "chorionic gonadotropin hormone receptor" EXACT [ISBN:0198506732]
is_a: GO:0016500 ! protein-hormone receptor activity
relationship: has_part GO:0038106 ! choriogonadotropin hormone binding
created_by: rfoulger
creation_date: 2010-04-22T04:49:57Z

[Term]
id: GO:0035473
name: lipase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any lipase." [GOC:BHF]
is_a: GO:0019899 ! enzyme binding
created_by: rfoulger
creation_date: 2010-04-22T05:28:52Z

[Term]
id: GO:0035474
name: selective angioblast sprouting
namespace: biological_process
def: "The segregation of angioblasts into discrete arterial and venous vessels from one common precursor vessel." [GOC:dgh, PMID:19815777]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0048514 ! blood vessel morphogenesis
created_by: rfoulger
creation_date: 2010-04-23T10:03:55Z

[Term]
id: GO:0035475
name: angioblast cell migration involved in selective angioblast sprouting
namespace: biological_process
def: "The directional migration of angioblast cells as part of selective angioblast sprouting, which results in angioblast segregation into arterial and venous populations." [GOC:dgh, PMID:19815777]
is_a: GO:0035476 ! angioblast cell migration
intersection_of: GO:0035476 ! angioblast cell migration
intersection_of: part_of GO:0035474 ! selective angioblast sprouting
relationship: part_of GO:0035474 ! selective angioblast sprouting
created_by: rfoulger
creation_date: 2010-04-23T10:04:30Z

[Term]
id: GO:0035476
name: angioblast cell migration
namespace: biological_process
def: "The orderly movement of angioblasts, cells involved in blood vessel morphogenesis." [GOC:dgh, PMID:19815777]
is_a: GO:0016477 ! cell migration
relationship: part_of GO:0048514 ! blood vessel morphogenesis
created_by: rfoulger
creation_date: 2010-04-23T10:06:32Z

[Term]
id: GO:0035477
name: regulation of angioblast cell migration involved in selective angioblast sprouting
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of angioblast cell migration involved in selective angioblast sprouting." [GOC:dgh, PMID:19815777]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0030334 ! regulation of cell migration
is_a: GO:1901342 ! regulation of vasculature development
relationship: regulates GO:0035475 ! angioblast cell migration involved in selective angioblast sprouting
created_by: rfoulger
creation_date: 2010-04-23T10:08:28Z

[Term]
id: GO:0035478
name: chylomicron binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a chylomicron, a large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE." [GOC:BHF, http://www.britannica.com/EBchecked/topic/117461/chylomicron]
is_a: GO:0071813 ! lipoprotein particle binding
created_by: rfoulger
creation_date: 2010-04-23T10:18:52Z

[Term]
id: GO:0035479
name: angioblast cell migration from lateral mesoderm to midline
namespace: biological_process
def: "The directed movement of angioblasts from the lateral mesoderm to the midline which occurs as part of the formation of the early midline vasculature." [GOC:dgh, PMID:11861480]
is_a: GO:0035476 ! angioblast cell migration
created_by: rfoulger
creation_date: 2010-04-23T10:38:05Z

[Term]
id: GO:0035480
name: regulation of Notch signaling pathway involved in heart induction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to heart induction." [GOC:BHF]
synonym: "regulation of Notch signalling pathway involved in heart induction" EXACT [GOC:mah]
is_a: GO:0008593 ! regulation of Notch signaling pathway
is_a: GO:0090381 ! regulation of heart induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003137 ! Notch signaling pathway involved in heart induction
relationship: regulates GO:0003137 ! Notch signaling pathway involved in heart induction
created_by: rfoulger
creation_date: 2010-04-23T10:40:48Z

[Term]
id: GO:0035481
name: positive regulation of Notch signaling pathway involved in heart induction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to heart induction." [GOC:BHF]
synonym: "positive regulation of Notch signalling pathway involved in heart induction" EXACT [GOC:mah]
is_a: GO:0035480 ! regulation of Notch signaling pathway involved in heart induction
is_a: GO:0045747 ! positive regulation of Notch signaling pathway
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1901321 ! positive regulation of heart induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003137 ! Notch signaling pathway involved in heart induction
relationship: positively_regulates GO:0003137 ! Notch signaling pathway involved in heart induction
created_by: rfoulger
creation_date: 2010-04-23T10:41:04Z

[Term]
id: GO:0035482
name: gastric motility
namespace: biological_process
def: "The spontaneous peristaltic movements of the stomach that aid in digestion, moving food through the stomach and out through the pyloric sphincter into the duodenum." [GOC:cy, ISBN:9781416032458, PMID:16139031]
is_a: GO:0022600 ! digestive system process
created_by: rfoulger
creation_date: 2010-04-23T10:44:59Z

[Term]
id: GO:0035483
name: gastric emptying
namespace: biological_process
def: "The process in which the liquid and liquid-suspended solid contents of the stomach exit through the pylorus into the duodenum." [GOC:cy, ISBN:9781416032458]
is_a: GO:0035482 ! gastric motility
created_by: rfoulger
creation_date: 2010-04-23T10:51:33Z

[Term]
id: GO:0035484
name: adenine/adenine mispair binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with double-stranded DNA containing an A/A mispair." [GOC:bf, GOC:jh]
synonym: "A/A mispair binding" EXACT [GOC:jh]
is_a: GO:0030983 ! mismatched DNA binding
created_by: rfoulger
creation_date: 2010-04-23T10:54:52Z

[Term]
id: GO:0035485
name: adenine/guanine mispair binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with double-stranded DNA containing an A/G mispair." [GOC:bf, GOC:jh]
synonym: "A/G mispair binding" EXACT [GOC:jh]
synonym: "G/A mispair binding" RELATED [GOC:bf]
synonym: "guanine-adenine mispair binding" EXACT [GOC:bf]
is_a: GO:0030983 ! mismatched DNA binding
created_by: rfoulger
creation_date: 2010-04-23T10:55:43Z

[Term]
id: GO:0035486
name: cytosine/cytosine mispair binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with double-stranded DNA containing a C/C mispair." [GOC:bf, GOC:jh]
synonym: "C/C mispair binding" EXACT [GOC:jh]
is_a: GO:0030983 ! mismatched DNA binding
created_by: rfoulger
creation_date: 2010-04-23T10:56:10Z

[Term]
id: GO:0035487
name: thymine/thymine mispair binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with double-stranded DNA containing a T/T mispair." [GOC:bf, GOC:jh]
synonym: "T/T mispair binding" EXACT []
is_a: GO:0030983 ! mismatched DNA binding
created_by: rfoulger
creation_date: 2010-04-23T10:56:37Z

[Term]
id: GO:0035488
name: cytosine/thymine mispair binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with double-stranded DNA containing a C/T mispair." [GOC:bf, GOC:jh]
synonym: "C/T mispair binding" EXACT [GOC:jh]
synonym: "T/C mispair binding" EXACT [GOC:bf]
synonym: "thymine/cytosine mispair binding" EXACT [GOC:bf]
is_a: GO:0030983 ! mismatched DNA binding
created_by: rfoulger
creation_date: 2010-04-23T10:57:13Z

[Term]
id: GO:0035489
name: guanine/guanine mispair binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with double-stranded DNA containing a G/G mispair." [GOC:bf, GOC:jh]
synonym: "G/G mispair binding" EXACT [GOC:jh]
is_a: GO:0030983 ! mismatched DNA binding
created_by: rfoulger
creation_date: 2010-04-23T11:16:55Z

[Term]
id: GO:0035490
name: regulation of leukotriene production involved in inflammatory response
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the synthesis or release of any leukotriene following a stimulus as part of an inflammatory response." [GOC:bf]
is_a: GO:0050727 ! regulation of inflammatory response
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002540 ! leukotriene production involved in inflammatory response
relationship: regulates GO:0002540 ! leukotriene production involved in inflammatory response
created_by: rfoulger
creation_date: 2010-04-26T10:49:22Z

[Term]
id: GO:0035491
name: positive regulation of leukotriene production involved in inflammatory response
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the synthesis or release of any leukotriene following a stimulus as part of an inflammatory response." [GOC:bf]
is_a: GO:0035490 ! regulation of leukotriene production involved in inflammatory response
is_a: GO:0050729 ! positive regulation of inflammatory response
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002540 ! leukotriene production involved in inflammatory response
relationship: positively_regulates GO:0002540 ! leukotriene production involved in inflammatory response
created_by: rfoulger
creation_date: 2010-04-26T10:50:14Z

[Term]
id: GO:0035492
name: negative regulation of leukotriene production involved in inflammatory response
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the synthesis or release of any leukotriene following a stimulus as part of an inflammatory response." [GOC:bf]
is_a: GO:0035490 ! regulation of leukotriene production involved in inflammatory response
is_a: GO:0050728 ! negative regulation of inflammatory response
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002540 ! leukotriene production involved in inflammatory response
relationship: negatively_regulates GO:0002540 ! leukotriene production involved in inflammatory response
created_by: rfoulger
creation_date: 2010-04-26T10:50:55Z

[Term]
id: GO:0035493
name: SNARE complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a SNARE complex, a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb, PMID:10872468]
is_a: GO:0043623 ! cellular protein complex assembly
relationship: part_of GO:0006906 ! vesicle fusion
created_by: rfoulger
creation_date: 2010-04-26T02:50:52Z

[Term]
id: GO:0035494
name: SNARE complex disassembly
namespace: biological_process
def: "The disaggregation of the SNARE protein complex into its constituent components. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb, PMID:11697877]
is_a: GO:0043624 ! cellular protein complex disassembly
relationship: part_of GO:0016192 ! vesicle-mediated transport
created_by: rfoulger
creation_date: 2010-04-26T02:54:17Z

[Term]
id: GO:0035495
name: regulation of SNARE complex disassembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of disassembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb]
is_a: GO:0043244 ! regulation of protein complex disassembly
is_a: GO:0060627 ! regulation of vesicle-mediated transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035494 ! SNARE complex disassembly
relationship: regulates GO:0035494 ! SNARE complex disassembly
created_by: rfoulger
creation_date: 2010-04-26T02:56:53Z

[Term]
id: GO:0035496
name: lipopolysaccharide-1,5-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,5 alpha-D-galactosyl-lipopolysaccharide." [EC:2.4.1.-, PMID:11304545]
synonym: "LPS-1,5-galactosyltransferase activity" EXACT [PMID:11304545]
synonym: "UDP-D-galactose:(glucosyl)lipopolysaccharide-1,5-D-galactosyltransferase" EXACT [PMID:11304545]
xref: EC:2.4.1.-
is_a: GO:0035250 ! UDP-galactosyltransferase activity
created_by: rfoulger
creation_date: 2010-04-26T03:00:21Z

[Term]
id: GO:0035497
name: cAMP response element binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the cyclic AMP response element (CRE), a short palindrome-containing sequence found in the promoters of genes whose expression is regulated in response to cyclic AMP." [PMID:2875459, PMID:2900470]
comment: Note that as agreed during the transcription overhaul, terms specifying binding to specific transcription regulatory motifs are no longer being created. The level of specificity GO has decided to go to is the "core promoter", "core promoter proximal region" and "enhancer". To capture more detail, please consider using column 16.
synonym: "cAMP-responsive element binding" EXACT [PMID:2875459]
synonym: "CRE binding" EXACT [PMID:2900470]
synonym: "cyclic AMP response element binding" EXACT [PMID:2900470]
synonym: "cyclic-AMP response element binding" EXACT [PMID:2900470]
synonym: "cyclic-AMP-responsive element binding" EXACT [PMID:2875459]
is_a: GO:0044212 ! transcription regulatory region DNA binding
created_by: rfoulger
creation_date: 2010-04-29T09:26:47Z

[Term]
id: GO:0035498
name: carnosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the dipeptide beta-alanyl-L-histidine (carnosine)." [PMID:20097752]
synonym: "carnosine metabolism" EXACT []
is_a: GO:0006518 ! peptide metabolic process
is_a: GO:1901605 ! alpha-amino acid metabolic process
created_by: rfoulger
creation_date: 2010-04-29T01:19:52Z

[Term]
id: GO:0035499
name: carnosine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the dipeptide beta-alanyl-L-histidine (carnosine)." [EC:6.3.2.11, PMID:20097752]
synonym: "carnosine anabolism" EXACT []
synonym: "carnosine biosynthesis" EXACT []
synonym: "carnosine formation" EXACT []
synonym: "carnosine synthesis" EXACT []
is_a: GO:0035498 ! carnosine metabolic process
is_a: GO:0043043 ! peptide biosynthetic process
is_a: GO:1901607 ! alpha-amino acid biosynthetic process
created_by: rfoulger
creation_date: 2010-04-29T01:20:56Z

[Term]
id: GO:0035500
name: MH2 domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the MH2 (MAD homology 2) domain of a protein. The MH2 domain is found at the carboxy terminus of MAD related proteins such as Smads. The MH2 domain mediates interaction with a wide variety of proteins and provides specificity and selectivity to Smad function and also is critical for mediating interactions in Smad oligomers." [Pfam:PF03166]
synonym: "MAD homology 2 domain binding" EXACT [Pfam:PF03166]
is_a: GO:0019904 ! protein domain specific binding
created_by: rfoulger
creation_date: 2010-04-29T03:14:32Z

[Term]
id: GO:0035501
name: MH1 domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the MH1 (MAD homology 1) domain of a protein. The MH1 domain is found at the amino terminus of MAD related proteins such as Smads and can mediate DNA binding in some proteins. Smads also use the MH1 domain to interact with some transcription factors." [Pfam:PF03165]
synonym: "MAD homology 1 domain binding" EXACT [Pfam:PF03165]
is_a: GO:0019904 ! protein domain specific binding
created_by: rfoulger
creation_date: 2010-04-29T03:17:27Z

[Term]
id: GO:0035502
name: metanephric part of ureteric bud development
namespace: biological_process
def: "The development of the portion of the ureteric bud tube that contributes to the morphogenesis of the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0035295 ! tube development
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0001657 ! ureteric bud development
relationship: part_of GO:0003338 ! metanephros morphogenesis
created_by: rfoulger
creation_date: 2010-04-29T03:22:21Z

[Term]
id: GO:0035503
name: ureter part of ureteric bud development
namespace: biological_process
def: "The development of the portion of the ureteric bud that contributes to the morphogenesis of the ureter. The ureter ureteric bud is the initial structure that forms the ureter." [GOC:mtg_kidney_jan10]
is_a: GO:0035295 ! tube development
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0001657 ! ureteric bud development
relationship: part_of GO:0072197 ! ureter morphogenesis
created_by: rfoulger
creation_date: 2010-04-29T03:23:42Z

[Term]
id: GO:0035504
name: regulation of myosin light chain kinase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of myosin light chain kinase activity." [GOC:bf, GOC:go_curators]
is_a: GO:0071900 ! regulation of protein serine/threonine kinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004687 ! myosin light chain kinase activity
relationship: regulates GO:0004687 ! myosin light chain kinase activity
created_by: rfoulger
creation_date: 2010-04-30T10:47:11Z

[Term]
id: GO:0035505
name: positive regulation of myosin light chain kinase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of myosin light chain kinase activity." [GOC:bf, GOC:go_curators]
is_a: GO:0035504 ! regulation of myosin light chain kinase activity
is_a: GO:0071902 ! positive regulation of protein serine/threonine kinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004687 ! myosin light chain kinase activity
relationship: positively_regulates GO:0004687 ! myosin light chain kinase activity
created_by: rfoulger
creation_date: 2010-04-30T10:48:09Z

[Term]
id: GO:0035506
name: negative regulation of myosin light chain kinase activity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of myosin light chain kinase activity." [GOC:bf, GOC:go_curators]
is_a: GO:0035504 ! regulation of myosin light chain kinase activity
is_a: GO:0071901 ! negative regulation of protein serine/threonine kinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004687 ! myosin light chain kinase activity
relationship: negatively_regulates GO:0004687 ! myosin light chain kinase activity
created_by: rfoulger
creation_date: 2010-04-30T10:49:21Z

[Term]
id: GO:0035507
name: regulation of myosin-light-chain-phosphatase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of myosin-light-chain-phosphatase activity." [GOC:bf, GOC:go_curators]
is_a: GO:0043666 ! regulation of phosphoprotein phosphatase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050115 ! myosin-light-chain-phosphatase activity
relationship: regulates GO:0050115 ! myosin-light-chain-phosphatase activity
created_by: rfoulger
creation_date: 2010-04-30T10:53:38Z

[Term]
id: GO:0035508
name: positive regulation of myosin-light-chain-phosphatase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of myosin-light-chain-phosphatase activity." [GOC:bf, GOC:go_curators]
is_a: GO:0032516 ! positive regulation of phosphoprotein phosphatase activity
is_a: GO:0035507 ! regulation of myosin-light-chain-phosphatase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0050115 ! myosin-light-chain-phosphatase activity
relationship: positively_regulates GO:0050115 ! myosin-light-chain-phosphatase activity
created_by: rfoulger
creation_date: 2010-04-30T10:55:05Z

[Term]
id: GO:0035509
name: negative regulation of myosin-light-chain-phosphatase activity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of myosin-light-chain-phosphatase activity." [GOC:bf, GOC:go_curators]
is_a: GO:0032515 ! negative regulation of phosphoprotein phosphatase activity
is_a: GO:0035507 ! regulation of myosin-light-chain-phosphatase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0050115 ! myosin-light-chain-phosphatase activity
relationship: negatively_regulates GO:0050115 ! myosin-light-chain-phosphatase activity
created_by: rfoulger
creation_date: 2010-04-30T10:56:34Z

[Term]
id: GO:0035510
name: DNA dealkylation
namespace: biological_process
def: "The removal of an alkyl group from one or more nucleotides within an DNA molecule." [GOC:bf]
is_a: GO:0006304 ! DNA modification
created_by: rfoulger
creation_date: 2010-04-30T02:20:08Z

[Term]
id: GO:0035511
name: oxidative DNA demethylation
namespace: biological_process
def: "Removal of the methyl group from one or more nucleotides within a DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms." [PMID:12594517, PMID:16482161, PMID:18775698]
is_a: GO:0070989 ! oxidative demethylation
is_a: GO:0080111 ! DNA demethylation
created_by: rfoulger
creation_date: 2010-04-30T02:22:44Z

[Term]
id: GO:0035512
name: hydrolytic DNA demethylation
namespace: biological_process
def: "The hydrolytic removal of the methyl group from one or more nucleotides within a DNA molecule." [GOC:bf]
is_a: GO:0080111 ! DNA demethylation
created_by: rfoulger
creation_date: 2010-04-30T02:24:21Z

[Term]
id: GO:0035513
name: oxidative RNA demethylation
namespace: biological_process
def: "The removal of the methyl group from one or more nucleotides within an RNA molecule involving oxidation (i.e. electron loss) of one or more atoms." [PMID:12594517, PMID:16482161, PMID:18775698]
is_a: GO:0009451 ! RNA modification
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0070989 ! oxidative demethylation
created_by: rfoulger
creation_date: 2010-04-30T02:25:35Z

[Term]
id: GO:0035514
name: DNA demethylase activity
namespace: molecular_function
def: "Catalysis of the removal of a methyl group from one or more nucleosides within a DNA molecule." [GOC:bf]
is_a: GO:0032451 ! demethylase activity
relationship: part_of GO:0080111 ! DNA demethylation
created_by: rfoulger
creation_date: 2010-04-30T02:36:43Z

[Term]
id: GO:0035515
name: oxidative RNA demethylase activity
namespace: molecular_function
def: "Catalysis of the removal of a methyl group from one or more nucleosides within a RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms." [PMID:12594517, PMID:16482161, PMID:18775698]
synonym: "2-oxoglutarate-dependent RNA demethylase" EXACT [PMID:17991826]
is_a: GO:0016491 ! oxidoreductase activity
is_a: GO:0032451 ! demethylase activity
relationship: part_of GO:0035513 ! oxidative RNA demethylation
created_by: rfoulger
creation_date: 2010-04-30T02:37:08Z

[Term]
id: GO:0035516
name: oxidative DNA demethylase activity
namespace: molecular_function
def: "Catalysis of the removal of the methyl group from one or more nucleotides within a DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms." [PMID:12594517, PMID:16482161, PMID:18775698]
synonym: "2-oxoglutarate-dependent DNA demethylase" EXACT [PMID:17991826]
is_a: GO:0016491 ! oxidoreductase activity
is_a: GO:0035514 ! DNA demethylase activity
relationship: part_of GO:0035511 ! oxidative DNA demethylation
created_by: rfoulger
creation_date: 2010-04-30T02:38:16Z

[Term]
id: GO:0035517
name: PR-DUB complex
namespace: cellular_component
def: "A multimeric protein complex that removes monoubiquitin from histone H2A. In Drosophila and mammals, the core of the complex is composed of Calypso/BAP1 and Asx/ASXL1, respectively." [PMID:20436459]
synonym: "Polycomb repressive deubiquitinase complex" EXACT [PMID:20436459]
is_a: GO:0031519 ! PcG protein complex
created_by: rfoulger
creation_date: 2010-05-04T04:19:02Z

[Term]
id: GO:0035518
name: histone H2A monoubiquitination
namespace: biological_process
def: "The modification of histone H2A by addition of a single ubiquitin group." [PMID:18206970]
is_a: GO:0010390 ! histone monoubiquitination
is_a: GO:0033522 ! histone H2A ubiquitination
created_by: rfoulger
creation_date: 2010-05-04T04:22:09Z

[Term]
id: GO:0035519
name: protein K29-linked ubiquitination
namespace: biological_process
def: "A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 29 of the ubiquitin monomers, is added to a protein. K29-linked ubiquitination targets the substrate protein for degradation." [PMID:17028573]
synonym: "protein K29-linked polyubiquitination" EXACT [GOC:mah]
is_a: GO:0000209 ! protein polyubiquitination
created_by: rfoulger
creation_date: 2010-05-04T04:25:48Z

[Term]
id: GO:0035520
name: monoubiquitinated protein deubiquitination
namespace: biological_process
def: "The removal of the ubiquitin group from a monoubiquitinated protein." [GOC:bf]
synonym: "monoubiquitinated protein deubiquitinylation" EXACT []
synonym: "monoubiquitinated protein deubiquitylation" EXACT []
is_a: GO:0016579 ! protein deubiquitination
created_by: rfoulger
creation_date: 2010-05-04T04:28:38Z

[Term]
id: GO:0035521
name: monoubiquitinated histone deubiquitination
namespace: biological_process
def: "The removal of the ubiquitin group from a monoubiquitinated histone protein." [GOC:bf, PMID:20436459]
synonym: "monoubiquitinated histone deubiquitinylation" EXACT []
synonym: "monoubiquitinated histone deubiquitylation" EXACT []
is_a: GO:0016578 ! histone deubiquitination
is_a: GO:0035520 ! monoubiquitinated protein deubiquitination
created_by: rfoulger
creation_date: 2010-05-04T04:32:04Z

[Term]
id: GO:0035522
name: monoubiquitinated histone H2A deubiquitination
namespace: biological_process
def: "The removal of the ubiquitin group from a monoubiquitinated histone H2A protein." [GOC:bf, PMID:18226187, PMID:20436459]
synonym: "monoubiquitinated histone H2A deubiquitinylation" EXACT []
synonym: "monoubiquitinated histone H2A deubiquitylation" EXACT []
is_a: GO:0035521 ! monoubiquitinated histone deubiquitination
created_by: rfoulger
creation_date: 2010-05-04T04:32:53Z

[Term]
id: GO:0035523
name: protein K29-linked deubiquitination
namespace: biological_process
def: "A protein deubiquitination process in which a K29-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 29 of the ubiquitin monomers, is removed from a protein." [GOC:bf]
synonym: "protein K29-linked deubiquitinylation" EXACT []
synonym: "protein K29-linked deubiquitylation" EXACT []
is_a: GO:0016579 ! protein deubiquitination
created_by: rfoulger
creation_date: 2010-05-04T04:33:27Z

[Term]
id: GO:0035524
name: proline transmembrane transport
namespace: biological_process
def: "The directed movement of proline, pyrrolidine-2-carboxylic acid, across a membrane by means of some agent such as a transporter or pore." [GOC:vw]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "proline membrane transport" EXACT []
is_a: GO:0003333 ! amino acid transmembrane transport
is_a: GO:0015824 ! proline transport
is_a: GO:0098655 ! cation transmembrane transport
created_by: rfoulger
creation_date: 2010-05-04T04:52:46Z

[Term]
id: GO:0035525
name: NF-kappaB p50/p65 complex
namespace: cellular_component
def: "A heterodimer of NF-kappa B p50 and p65 subunits." [GO:add, PMID:20393192, PMID:9299584]
comment: Note that the p50 subunit is encoded by NFKB1 gene in human and the p65 subunit is encoded by the RELA gene in human. Similar nomenclature is used in other vertebrate species. The p50 subunit has a precursor form p105 in some publications.
synonym: "NF-kappa B1/p65 complex" EXACT [PMID:9299584]
synonym: "NF-kappa B1/RelA complex" EXACT [PMID:9299584]
synonym: "NF-kappa p105/p65 complex" RELATED [PMID:9299584]
synonym: "NF-kappa p105/RelA complex" RELATED [PMID:9299584]
synonym: "NF-kappa p50/RelA complex" EXACT [PMID:9299584]
is_a: GO:0071159 ! NF-kappaB complex
created_by: rfoulger
creation_date: 2010-05-05T10:45:13Z

[Term]
id: GO:0035526
name: retrograde transport, plasma membrane to Golgi
namespace: biological_process
def: "The directed movement of substances from the plasma membrane back to the trans-Golgi network, mediated by vesicles." [GOC:lb, PMID:17488291]
is_a: GO:0016192 ! vesicle-mediated transport
is_a: GO:1902582 ! single-organism intracellular transport
created_by: rfoulger
creation_date: 2010-05-05T10:52:49Z

[Term]
id: GO:0035527
name: 3-hydroxypropionate dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxypropanoate + NADP+ = 3-oxopropanoate + H+ + NADPH." [RHEA:26441]
synonym: "3-hydroxypropanoate dehydrogenase (NADP+) activity" EXACT []
synonym: "3-hydroxypropanoate:NADP+ oxidoreductase" EXACT [EC:1.1.1.298]
synonym: "3-hydroxypropionate:NADP+ oxidoreductase" EXACT [EC:1.1.1.298]
xref: EC:1.1.1.298
xref: KEGG:R09289
xref: MetaCyc:RXN-8974
xref: RHEA:26441
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
created_by: rfoulger
creation_date: 2010-05-05T10:55:07Z

[Term]
id: GO:0035528
name: UDP-N-acetylglucosamine biosynthesis involved in chitin biosynthesis
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine in glycosidic linkage with uridine diphosphate, that contribute to the biosynthesis of chitin." [GOC:bf]
synonym: "UDP-GlcNAc biosynthesis involved in chitin biosynthesis" EXACT []
synonym: "UDP-GlcNAc biosynthetic process involved in chitin biosynthesis" EXACT []
synonym: "UDP-GlcNAc biosynthetic process involved in chitin biosynthetic process" EXACT []
synonym: "UDP-N-acetylglucosamine anabolism involved in chitin biosynthesis" EXACT []
synonym: "UDP-N-acetylglucosamine biosynthetic process involved in chitin biosynthetic process" EXACT []
synonym: "UDP-N-acetylglucosamine formation involved in chitin biosynthesis" EXACT []
synonym: "UDP-N-acetylglucosamine synthesis involved in chitin biosynthesis" EXACT []
is_a: GO:0006048 ! UDP-N-acetylglucosamine biosynthetic process
intersection_of: GO:0006048 ! UDP-N-acetylglucosamine biosynthetic process
intersection_of: part_of GO:0006031 ! chitin biosynthetic process
relationship: part_of GO:0006031 ! chitin biosynthetic process
created_by: rfoulger
creation_date: 2010-05-05T04:49:49Z

[Term]
id: GO:0035529
name: NADH pyrophosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADH + H2O = AMP + NMNH + 2 H+." [MetaCyc:RXN0-4401, PMID:12399474, PMID:20181750]
synonym: "NADH diphosphatase activity" EXACT []
synonym: "NADH pyrophosphohydrolase activity" EXACT []
xref: EC:3.6.1.9
xref: KEGG:R00103
xref: MetaCyc:RXN0-4401
is_a: GO:0004551 ! nucleotide diphosphatase activity
created_by: rfoulger
creation_date: 2010-05-05T04:55:10Z

[Term]
id: GO:0035530
name: chemokine (C-C motif) ligand 6 production
namespace: biological_process
def: "The appearance of chemokine (C-C motif) ligand 6 (CCL6) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, PMID:19812544]
synonym: "CCL6 production" EXACT []
is_a: GO:0032602 ! chemokine production
created_by: rfoulger
creation_date: 2010-05-07T10:21:15Z

[Term]
id: GO:0035531
name: regulation of chemokine (C-C motif) ligand 6 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of chemokine (C-C motif) ligand 6 (CCL6)." [GOC:add, GOC:bf]
synonym: "regulation of CCL6 production" EXACT []
is_a: GO:0032642 ! regulation of chemokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035530 ! chemokine (C-C motif) ligand 6 production
relationship: regulates GO:0035530 ! chemokine (C-C motif) ligand 6 production
created_by: rfoulger
creation_date: 2010-05-07T10:22:51Z

[Term]
id: GO:0035532
name: negative regulation of chemokine (C-C motif) ligand 6 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-C motif) ligand 6 (CCL6)." [GOC:add, GOC:bf]
synonym: "negative regulation of CCL6 production" EXACT []
is_a: GO:0032682 ! negative regulation of chemokine production
is_a: GO:0035531 ! regulation of chemokine (C-C motif) ligand 6 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035530 ! chemokine (C-C motif) ligand 6 production
relationship: negatively_regulates GO:0035530 ! chemokine (C-C motif) ligand 6 production
created_by: rfoulger
creation_date: 2010-05-07T10:23:40Z

[Term]
id: GO:0035533
name: positive regulation of chemokine (C-C motif) ligand 6 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-C motif) ligand 6 (CCL6)." [GOC:add, GOC:bf]
synonym: "positive regulation of CCL6 production" EXACT []
is_a: GO:0032722 ! positive regulation of chemokine production
is_a: GO:0035531 ! regulation of chemokine (C-C motif) ligand 6 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035530 ! chemokine (C-C motif) ligand 6 production
relationship: positively_regulates GO:0035530 ! chemokine (C-C motif) ligand 6 production
created_by: rfoulger
creation_date: 2010-05-07T10:24:21Z

[Term]
id: GO:0035534
name: chemokine (C-C motif) ligand 6 secretion
namespace: biological_process
def: "The regulated release of chemokine (C-C motif) ligand 6 (CCL6) from a cell." [GOC:add, GOC:amm]
synonym: "CCL6 secretion" EXACT []
is_a: GO:0090195 ! chemokine secretion
relationship: part_of GO:0035530 ! chemokine (C-C motif) ligand 6 production
created_by: rfoulger
creation_date: 2010-05-07T10:28:11Z

[Term]
id: GO:0035535
name: regulation of chemokine (C-C motif) ligand 6 secretion
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the regulated release of chemokine (C-C motif) ligand 6 (CCL6) from a cell." [GOC:add, GOC:bf]
synonym: "regulation of CCL6 secretion" EXACT []
is_a: GO:0035531 ! regulation of chemokine (C-C motif) ligand 6 production
is_a: GO:0090196 ! regulation of chemokine secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035534 ! chemokine (C-C motif) ligand 6 secretion
relationship: regulates GO:0035534 ! chemokine (C-C motif) ligand 6 secretion
created_by: rfoulger
creation_date: 2010-05-07T10:29:40Z

[Term]
id: GO:0035536
name: negative regulation of chemokine (C-C motif) ligand 6 secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the regulated release of chemokine (C-C motif) ligand 6 (CCL6) from a cell." [GOC:add, GOC:bf]
synonym: "negative regulation of CCL6 secretion" EXACT []
is_a: GO:0035532 ! negative regulation of chemokine (C-C motif) ligand 6 production
is_a: GO:0035535 ! regulation of chemokine (C-C motif) ligand 6 secretion
is_a: GO:0090198 ! negative regulation of chemokine secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035534 ! chemokine (C-C motif) ligand 6 secretion
relationship: negatively_regulates GO:0035534 ! chemokine (C-C motif) ligand 6 secretion
created_by: rfoulger
creation_date: 2010-05-07T10:30:14Z

[Term]
id: GO:0035537
name: positive regulation of chemokine (C-C motif) ligand 6 secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of the regulated release of chemokine (C-C motif) ligand 6 (CCL6) from a cell." [GOC:add, GOC:bf]
synonym: "positive regulation of CCL6 secretion" EXACT []
is_a: GO:0035533 ! positive regulation of chemokine (C-C motif) ligand 6 production
is_a: GO:0035535 ! regulation of chemokine (C-C motif) ligand 6 secretion
is_a: GO:0090197 ! positive regulation of chemokine secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035534 ! chemokine (C-C motif) ligand 6 secretion
relationship: positively_regulates GO:0035534 ! chemokine (C-C motif) ligand 6 secretion
created_by: rfoulger
creation_date: 2010-05-07T10:31:19Z

[Term]
id: GO:0035538
name: carbohydrate response element binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the carbohydrate response element (ChoRE) found in the promoters of genes whose expression is regulated in response to carbohydrates, such as the triglyceride synthesis genes." [GOC:BHF, PMID:20001964]
comment: Note that as agreed during the transcription overhaul, terms specifying binding to specific transcription regulatory motifs are no longer being created. The level of specificity GO has decided to go to is the "core promoter", "core promoter proximal region" and "enhancer". To capture more detail, please consider using column 16.
synonym: "ChoRE binding" EXACT [PMID:20001964]
is_a: GO:0044212 ! transcription regulatory region DNA binding
created_by: rfoulger
creation_date: 2010-05-07T10:48:30Z

[Term]
id: GO:0035539
name: 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate + diphosphate. 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate, or 8-oxo-dGTP, is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA." [PMID:17804481, PMID:7782328, PMID:7859359]
synonym: "8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase activity" EXACT [PMID:17804481]
synonym: "8-oxo-7,8-dihydro-deoxyguanosine triphosphate pyrophosphatase activity" EXACT [PMID:17804481]
synonym: "8-oxo-7,8-dihydrodeoxyguanosine triphosphatase activity" EXACT [PMID:7782328]
synonym: "8-oxo-dGTP pyrophosphohydrolase activity" EXACT [PMID:17804481]
synonym: "8-oxo-dGTPase activity" EXACT [PMID:7782328]
xref: RHEA:31578
is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity
created_by: rfoulger
creation_date: 2010-05-07T10:54:19Z

[Term]
id: GO:0035540
name: positive regulation of SNARE complex disassembly
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of disassembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb]
is_a: GO:0035495 ! regulation of SNARE complex disassembly
is_a: GO:0043243 ! positive regulation of protein complex disassembly
is_a: GO:0051050 ! positive regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035494 ! SNARE complex disassembly
relationship: positively_regulates GO:0035494 ! SNARE complex disassembly
created_by: rfoulger
creation_date: 2010-05-10T01:42:21Z

[Term]
id: GO:0035541
name: negative regulation of SNARE complex disassembly
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of disassembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb]
is_a: GO:0035495 ! regulation of SNARE complex disassembly
is_a: GO:0043242 ! negative regulation of protein complex disassembly
is_a: GO:0051051 ! negative regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035494 ! SNARE complex disassembly
relationship: negatively_regulates GO:0035494 ! SNARE complex disassembly
created_by: rfoulger
creation_date: 2010-05-10T01:42:47Z

[Term]
id: GO:0035542
name: regulation of SNARE complex assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb]
is_a: GO:0031338 ! regulation of vesicle fusion
is_a: GO:0043254 ! regulation of protein complex assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035493 ! SNARE complex assembly
relationship: regulates GO:0035493 ! SNARE complex assembly
created_by: rfoulger
creation_date: 2010-05-10T01:49:35Z

[Term]
id: GO:0035543
name: positive regulation of SNARE complex assembly
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb]
is_a: GO:0031334 ! positive regulation of protein complex assembly
is_a: GO:0031340 ! positive regulation of vesicle fusion
is_a: GO:0035542 ! regulation of SNARE complex assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035493 ! SNARE complex assembly
relationship: positively_regulates GO:0035493 ! SNARE complex assembly
created_by: rfoulger
creation_date: 2010-05-10T01:50:02Z

[Term]
id: GO:0035544
name: negative regulation of SNARE complex assembly
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb]
is_a: GO:0031333 ! negative regulation of protein complex assembly
is_a: GO:0031339 ! negative regulation of vesicle fusion
is_a: GO:0035542 ! regulation of SNARE complex assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035493 ! SNARE complex assembly
relationship: negatively_regulates GO:0035493 ! SNARE complex assembly
created_by: rfoulger
creation_date: 2010-05-10T01:51:10Z

[Term]
id: GO:0035545
name: determination of left/right asymmetry in nervous system
namespace: biological_process
def: "The establishment of the nervous system with respect to the left and right halves." [GOC:kmv, PMID:17717195, PMID:19641012]
is_a: GO:0007368 ! determination of left/right symmetry
relationship: part_of GO:0007399 ! nervous system development
created_by: rfoulger
creation_date: 2010-05-11T01:53:33Z

[Term]
id: GO:0035546
name: interferon-beta secretion
namespace: biological_process
def: "The regulated release of interferon-beta from a cell." [GOC:add, GOC:bf]
synonym: "IFN-beta secretion" EXACT []
synonym: "IFNB secretion" EXACT [GOC:mah]
is_a: GO:0072641 ! type I interferon secretion
relationship: part_of GO:0032608 ! interferon-beta production
created_by: rfoulger
creation_date: 2010-05-12T10:04:11Z

[Term]
id: GO:0035547
name: regulation of interferon-beta secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interferon-beta secretion." [GOC:add, GOC:bf]
synonym: "regulation of IFN-beta secretion" EXACT []
is_a: GO:0032648 ! regulation of interferon-beta production
is_a: GO:0050707 ! regulation of cytokine secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035546 ! interferon-beta secretion
relationship: regulates GO:0035546 ! interferon-beta secretion
created_by: rfoulger
creation_date: 2010-05-12T10:06:03Z

[Term]
id: GO:0035548
name: negative regulation of interferon-beta secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-beta secretion." [GOC:add, GOC:bf]
synonym: "down regulation of interferon-beta secretion" EXACT []
synonym: "down-regulation of interferon-beta secretion" EXACT []
synonym: "downregulation of interferon-beta secretion" EXACT []
synonym: "inhibition of interferon-beta secretion" NARROW []
synonym: "negative regulation of IFN-beta secretion" EXACT []
is_a: GO:0032688 ! negative regulation of interferon-beta production
is_a: GO:0035547 ! regulation of interferon-beta secretion
is_a: GO:0050710 ! negative regulation of cytokine secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035546 ! interferon-beta secretion
relationship: negatively_regulates GO:0035546 ! interferon-beta secretion
created_by: rfoulger
creation_date: 2010-05-12T10:06:28Z

[Term]
id: GO:0035549
name: positive regulation of interferon-beta secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interferon-beta secretion." [GOC:add, GOC:bf]
synonym: "activation of interferon-beta secretion" NARROW []
synonym: "positive regulation of IFN-beta secretion" EXACT []
synonym: "stimulation of interferon-beta secretion" NARROW []
synonym: "up regulation of interferon-beta secretion" EXACT []
synonym: "up-regulation of interferon-beta secretion" EXACT []
synonym: "upregulation of interferon-beta secretion" EXACT []
is_a: GO:0032728 ! positive regulation of interferon-beta production
is_a: GO:0035547 ! regulation of interferon-beta secretion
is_a: GO:0050715 ! positive regulation of cytokine secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035546 ! interferon-beta secretion
relationship: positively_regulates GO:0035546 ! interferon-beta secretion
created_by: rfoulger
creation_date: 2010-05-12T10:06:50Z

[Term]
id: GO:0035550
name: urease complex
namespace: cellular_component
def: "A multiprotein nickel-containing complex that possesses urease activity (catalysis of the hydrolysis of urea to ammonia and carbon dioxide)." [InterPro:IPR008221, PMID:2651866]
comment: Eukaryotic microorganisms, plants, and probably Gram-positive bacteria, possess a homopolymeric urease. In contrast, urease complexes from gram-negative bacteria studied thus far clearly possess three distinct subunits (alpha, beta and gamma). Tightly bound nickel is present in all urease complexes.
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:1902494 ! catalytic complex
created_by: rfoulger
creation_date: 2010-05-12T01:00:27Z

[Term]
id: GO:0035551
name: protein initiator methionine removal involved in protein maturation
namespace: biological_process
def: "Removal of the initiating methionine or formylmethionine residue from a protein that contributes to protein maturation, the attainment of the full functional capacity of a protein." [GOC:bf, GOC:hjd, GOC:vw]
is_a: GO:0016485 ! protein processing
is_a: GO:0070084 ! protein initiator methionine removal
intersection_of: GO:0070084 ! protein initiator methionine removal
intersection_of: part_of GO:0051604 ! protein maturation
relationship: part_of GO:0051604 ! protein maturation
created_by: rfoulger
creation_date: 2010-05-13T04:29:05Z

[Term]
id: GO:0035552
name: oxidative single-stranded DNA demethylation
namespace: biological_process
def: "Removal of the methyl group from one or more nucleotides within a single-stranded DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms." [GOC:BHF, GOC:rl, PMID:18775698]
synonym: "oxidative ssDNA demethylation" EXACT []
is_a: GO:0035511 ! oxidative DNA demethylation
created_by: rfoulger
creation_date: 2010-05-14T11:03:55Z

[Term]
id: GO:0035553
name: oxidative single-stranded RNA demethylation
namespace: biological_process
def: "Removal of the methyl group from one or more nucleotides within a single-stranded RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms." [GOC:BHF, GOC:rl, PMID:18775698]
synonym: "oxidative ssRNA demethylation" EXACT []
is_a: GO:0035513 ! oxidative RNA demethylation
created_by: rfoulger
creation_date: 2010-05-14T11:05:17Z

[Term]
id: GO:0035554
name: termination of Roundabout signal transduction
namespace: biological_process
def: "The signaling process in which signaling from the receptor ROBO is brought to an end, rather than being reversibly modulated." [GOC:BHF, GOC:vk]
is_a: GO:0023021 ! termination of signal transduction
is_a: GO:0035387 ! negative regulation of Roundabout signaling pathway
relationship: part_of GO:0035385 ! Roundabout signaling pathway
created_by: rfoulger
creation_date: 2010-05-14T11:08:12Z

[Term]
id: GO:0035555
name: obsolete initiation of Roundabout signal transduction
namespace: biological_process
def: "OBSOLETE. The process in which a SLIT protein causes activation of the receptor, Roundabout (ROBO)." [GOC:vk]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "initiation of Roundabout signal transduction" EXACT []
is_obsolete: true
consider: GO:0004872
consider: GO:0035385
consider: GO:0048018
consider: GO:0048495
created_by: rfoulger
creation_date: 2010-05-14T11:10:20Z

[Term]
id: GO:0035556
name: intracellular signal transduction
namespace: biological_process
alt_id: GO:0007242
alt_id: GO:0007243
alt_id: GO:0023013
alt_id: GO:0023034
def: "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
synonym: "intracellular protein kinase cascade" NARROW [GOC:signaling]
synonym: "intracellular signal transduction pathway" NARROW []
synonym: "intracellular signaling cascade" RELATED [GOC:signaling]
synonym: "intracellular signaling chain" EXACT [ISBN:3527303782]
synonym: "intracellular signaling pathway" RELATED []
synonym: "protein kinase cascade" NARROW [GOC:signaling]
synonym: "signal transduction via intracellular signaling cascade" RELATED []
synonym: "signal transmission via intracellular cascade" NARROW []
xref: Reactome:REACT_100795 "PKA-mediated phosphorylation of key metabolic factors, Saccharomyces cerevisiae"
xref: Reactome:REACT_102462 "PKA-mediated phosphorylation of key metabolic factors, Canis familiaris"
xref: Reactome:REACT_104200 "PKA-mediated phosphorylation of key metabolic factors, Taeniopygia guttata"
xref: Reactome:REACT_108216 "PKA-mediated phosphorylation of key metabolic factors, Dictyostelium discoideum"
xref: Reactome:REACT_1525 "PKA-mediated phosphorylation of key metabolic factors, Homo sapiens"
xref: Reactome:REACT_80030 "PKA-mediated phosphorylation of key metabolic factors, Sus scrofa"
xref: Reactome:REACT_83068 "PKA-mediated phosphorylation of key metabolic factors, Gallus gallus"
xref: Reactome:REACT_83869 "PKA-mediated phosphorylation of key metabolic factors, Xenopus tropicalis"
xref: Reactome:REACT_87453 "PKA-mediated phosphorylation of key metabolic factors, Bos taurus"
xref: Reactome:REACT_89085 "PKA-mediated phosphorylation of key metabolic factors, Rattus norvegicus"
xref: Reactome:REACT_89983 "PKA-mediated phosphorylation of key metabolic factors, Danio rerio"
xref: Reactome:REACT_90740 "PKA-mediated phosphorylation of key metabolic factors, Schizosaccharomyces pombe"
xref: Reactome:REACT_99938 "PKA-mediated phosphorylation of key metabolic factors, Mus musculus"
is_a: GO:0007165 ! signal transduction
intersection_of: GO:0007165 ! signal transduction
intersection_of: occurs_in GO:0005622 ! intracellular
relationship: occurs_in GO:0005622 ! intracellular
created_by: rfoulger
creation_date: 2010-05-14T01:14:37Z

[Term]
id: GO:0035557
name: obsolete intracellular signal transduction involved in cell surface receptor linked signaling
namespace: biological_process
def: "OBSOLETE. The process in which a signal is passed on from a receptor at the cell surface to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]
comment: This term was made obsolete because the syntax of the term is incorrect.
synonym: "intracellular signal transduction involved in cell surface receptor linked signaling" EXACT []
synonym: "intracellular signal transduction involved in cell surface receptor linked signalling" EXACT [GOC:mah]
synonym: "intracellular signaling cascade involved in cell surface receptor linked signaling" EXACT []
synonym: "intracellular signaling chain involved in cell surface receptor signaling" EXACT [ISBN:3527303782]
is_obsolete: true
created_by: rfoulger
creation_date: 2010-05-14T01:31:05Z

[Term]
id: GO:0035558
name: obsolete phosphatidylinositol 3-kinase cascade involved in insulin receptor signaling
namespace: biological_process
def: "OBSOLETE. The process in which a signal is passed from the insulin receptor to components of the phosphatidylinositol 3-kinase (PI3K) cascade, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:signaling]
comment: This term was made obsolete because the syntax of the term is incorrect.
synonym: "phosphatidylinositol 3-kinase cascade involved in insulin receptor signaling" EXACT []
synonym: "phosphatidylinositol 3-kinase cascade involved in insulin receptor signalling" EXACT [GOC:curators]
synonym: "phosphoinositide 3-kinase cascade involved in insulin receptor signaling" EXACT [GOC:curators]
synonym: "phosphoinositide 3-kinase cascade involved in insulin receptor signalling" EXACT [GOC:mah]
synonym: "PI3K cascade involved in signaling from the insulin receptor" EXACT []
is_obsolete: true
consider: GO:0038028
created_by: rfoulger
creation_date: 2010-05-14T01:34:38Z

[Term]
id: GO:0035559
name: obsolete MAPKKK cascade involved in epidermal growth factor receptor signaling
namespace: biological_process
def: "OBSOLETE. The process in which a signal is passed from the epidermal growth factor receptor (EGFR) to components of the MAPKKK cascade, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling]
comment: This term was made obsolete because the syntax of the term is incorrect.
synonym: "MAPKKK cascade involved in epidermal growth factor receptor signaling" EXACT []
synonym: "MAPKKK cascade involved in epidermal growth factor receptor signalling" EXACT [GOC:mah]
synonym: "MAPKKK cascade involved in signaling from the EGFR" EXACT []
is_obsolete: true
consider: GO:0038029
created_by: rfoulger
creation_date: 2010-05-14T01:53:15Z

[Term]
id: GO:0035560
name: pheophoridase activity
namespace: molecular_function
def: "Catalysis of the reaction: pheophorbide a + H2O = pyropheophorbide a + methanol + CO2. The reaction occurs in two steps; pheophoridase catalyzes the conversion of pheophorbide a to a precursor of pyropheophorbide a, C-13(2)-carboxylpyropheophorbide a, by demethylation, and then the precursor is decarboxylated non-enzymatically to yield pyropheophorbide a." [EC:3.1.1.82, PMID:16228561]
synonym: "phedase activity" EXACT [EC:3.1.1.82]
synonym: "PPD activity" EXACT [EC:3.1.1.82]
xref: EC:3.1.1.82
xref: RHEA:24784
is_a: GO:0052689 ! carboxylic ester hydrolase activity
created_by: rfoulger
creation_date: 2010-05-14T02:39:58Z

[Term]
id: GO:0035561
name: regulation of chromatin binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:bf, PMID:20404130]
is_a: GO:0051098 ! regulation of binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003682 ! chromatin binding
relationship: regulates GO:0003682 ! chromatin binding
created_by: rfoulger
creation_date: 2010-05-19T10:28:36Z

[Term]
id: GO:0035562
name: negative regulation of chromatin binding
namespace: biological_process
def: "Any process that stops or reduces the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:bf, PMID:20404130]
is_a: GO:0035561 ! regulation of chromatin binding
is_a: GO:0051100 ! negative regulation of binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003682 ! chromatin binding
relationship: negatively_regulates GO:0003682 ! chromatin binding
created_by: rfoulger
creation_date: 2010-05-19T10:29:06Z

[Term]
id: GO:0035563
name: positive regulation of chromatin binding
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:bf, PMID:20404130]
is_a: GO:0035561 ! regulation of chromatin binding
is_a: GO:0051099 ! positive regulation of binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003682 ! chromatin binding
relationship: positively_regulates GO:0003682 ! chromatin binding
created_by: rfoulger
creation_date: 2010-05-19T10:29:41Z

[Term]
id: GO:0035564
name: regulation of kidney size
namespace: biological_process
def: "Any process that modulates the size of a kidney." [GOC:bf]
is_a: GO:0090066 ! regulation of anatomical structure size
relationship: part_of GO:0060993 ! kidney morphogenesis
created_by: rfoulger
creation_date: 2010-07-23T11:28:22Z

[Term]
id: GO:0035565
name: regulation of pronephros size
namespace: biological_process
def: "Any process that modulates the size of a pronephric kidney." [GOC:bf]
synonym: "regulation of pronephric kidney size" EXACT [GOC:bf]
is_a: GO:0035564 ! regulation of kidney size
relationship: part_of GO:0072114 ! pronephros morphogenesis
created_by: rfoulger
creation_date: 2010-07-23T11:28:57Z

[Term]
id: GO:0035566
name: regulation of metanephros size
namespace: biological_process
def: "Any process that modulates the size of a metanephric kidney." [GOC:bf]
synonym: "regulation of metanephric kidney size" EXACT [GOC:bf]
is_a: GO:0035564 ! regulation of kidney size
relationship: part_of GO:0003338 ! metanephros morphogenesis
created_by: rfoulger
creation_date: 2010-07-23T11:34:06Z

[Term]
id: GO:0035567
name: non-canonical Wnt signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors other than beta-catenin." [GOC:signaling]
comment: This term should only be used when Wnt receptor signaling occurs via a beta-catenin-independent route but the downstream effectors are unknown. If the downstream effectors are known, consider instead annotating to one of the children, or requesting a new term.
synonym: "beta-catenin-independent Wnt receptor signaling pathway" EXACT [GOC:signaling]
synonym: "non-canonical Wnt receptor signaling pathway" EXACT []
synonym: "non-canonical Wnt receptor signalling pathway" EXACT [GOC:mah]
synonym: "non-canonical Wnt-activated signaling pathway" EXACT [GOC:signaling]
is_a: GO:0016055 ! Wnt signaling pathway
created_by: rfoulger
creation_date: 2010-07-23T02:26:01Z

[Term]
id: GO:0035568
name: N-terminal peptidyl-proline methylation
namespace: biological_process
def: "The methylation of the N-terminal proline of proteins." [PMID:20668449, RESID:AA0419]
xref: RESID:AA0419
is_a: GO:0006480 ! N-terminal protein amino acid methylation
is_a: GO:0018208 ! peptidyl-proline modification
created_by: rfoulger
creation_date: 2010-08-06T01:52:43Z

[Term]
id: GO:0035569
name: obsolete N-terminal peptidyl-proline trimethylation
namespace: biological_process
def: "The trimethylation of the N-terminal proline of proteins to form the derivative N,N,N-trimethylproline." [PMID:20668449]
comment: This term was made obsolete because N-terminal proline residues cannot be trimethylated.
synonym: "N-terminal peptidyl-proline trimethylation" EXACT []
is_obsolete: true
created_by: rfoulger
creation_date: 2010-08-06T01:55:19Z

[Term]
id: GO:0035570
name: N-terminal peptidyl-serine methylation
namespace: biological_process
def: "The methylation of the N-terminal serine of proteins." [PMID:20668449]
is_a: GO:0006480 ! N-terminal protein amino acid methylation
is_a: GO:0018209 ! peptidyl-serine modification
created_by: rfoulger
creation_date: 2010-08-06T01:58:11Z

[Term]
id: GO:0035571
name: N-terminal peptidyl-serine monomethylation
namespace: biological_process
def: "The monomethylation of the N-terminal serine of proteins to form the derivative N-methylserine." [PMID:20668449]
is_a: GO:0035570 ! N-terminal peptidyl-serine methylation
created_by: rfoulger
creation_date: 2010-08-06T01:58:56Z

[Term]
id: GO:0035572
name: N-terminal peptidyl-serine dimethylation
namespace: biological_process
def: "The dimethylation of the N-terminal serine of proteins to form the derivative N,N-dimethylserine." [PMID:20668449]
is_a: GO:0035570 ! N-terminal peptidyl-serine methylation
created_by: rfoulger
creation_date: 2010-08-06T02:00:17Z

[Term]
id: GO:0035573
name: N-terminal peptidyl-serine trimethylation
namespace: biological_process
def: "The trimethylation of the N-terminal serine of proteins to form the derivative N,N,N-trimethylserine." [PMID:20668449]
is_a: GO:0035570 ! N-terminal peptidyl-serine methylation
created_by: rfoulger
creation_date: 2010-08-06T02:00:42Z

[Term]
id: GO:0035574
name: histone H4-K20 demethylation
namespace: biological_process
def: "The modification of histone H4 by the removal of a methyl group from lysine at position 20 of the histone." [GOC:sp, PMID:20622853]
is_a: GO:0070076 ! histone lysine demethylation
created_by: rfoulger
creation_date: 2010-08-13T10:50:06Z

[Term]
id: GO:0035575
name: histone demethylase activity (H4-K20 specific)
namespace: molecular_function
def: "Catalysis of the reaction: histone H4 N6-methyl-L-lysine (position 20) + 2-oxoglutarate + O2 = histone H4 L-lysine (position 20) + succinate + formaldehyde + CO2. This reaction is the removal of a methyl group from lysine at position 20 of the histone H4 protein." [EC:1.14.11.27, PMID:20622853]
is_a: GO:0032452 ! histone demethylase activity
relationship: part_of GO:0035574 ! histone H4-K20 demethylation
created_by: rfoulger
creation_date: 2010-08-13T10:51:13Z

[Term]
id: GO:0035576
name: retinoic acid receptor signaling pathway involved in pronephric field specification
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that results in regions of the embryo being delineated into the area in which the pronephric kidney will develop." [GOC:bf, PMID:16979153, PMID:19909807]
synonym: "retinoic acid receptor signalling pathway involved in pronephric field specification" EXACT [GOC:mah]
is_a: GO:0048384 ! retinoic acid receptor signaling pathway
intersection_of: GO:0048384 ! retinoic acid receptor signaling pathway
intersection_of: part_of GO:0039003 ! pronephric field specification
relationship: part_of GO:0039003 ! pronephric field specification
created_by: rfoulger
creation_date: 2010-10-05T01:19:35Z

[Term]
id: GO:0035577
name: azurophil granule membrane
namespace: cellular_component
def: "The lipid bilayer surrounding an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid." [GOC:bf, PMID:17152095]
synonym: "primary granule membrane" EXACT []
is_a: GO:0005765 ! lysosomal membrane
is_a: GO:0030667 ! secretory granule membrane
relationship: part_of GO:0042582 ! azurophil granule
created_by: rfoulger
creation_date: 2010-10-05T01:29:10Z

[Term]
id: GO:0035578
name: azurophil granule lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid." [GOC:bf, PMID:17152095]
synonym: "primary granule lumen" EXACT []
is_a: GO:0005775 ! vacuolar lumen
is_a: GO:0034774 ! secretory granule lumen
relationship: part_of GO:0042582 ! azurophil granule
created_by: rfoulger
creation_date: 2010-10-05T01:30:33Z

[Term]
id: GO:0035579
name: specific granule membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase." [GOC:bf, PMID:7334549]
synonym: "secondary granule membrane" EXACT []
is_a: GO:0030667 ! secretory granule membrane
relationship: part_of GO:0042581 ! specific granule
created_by: rfoulger
creation_date: 2010-10-05T01:32:47Z

[Term]
id: GO:0035580
name: specific granule lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase." [GOC:bf, PMID:7334549]
synonym: "secondary granule lumen" EXACT []
is_a: GO:0034774 ! secretory granule lumen
relationship: part_of GO:0042581 ! specific granule
created_by: rfoulger
creation_date: 2010-10-05T01:33:53Z

[Term]
id: GO:0035581
name: sequestering of extracellular ligand from receptor
namespace: biological_process
def: "The process of binding or confining an extracellular signaling ligand, such that the ligand is unable to bind to its cell surface receptor." [GOC:BHF, GOC:signaling]
comment: Preventing a ligand from binding to its cell surface receptor be achieved by binding to the ligand directly, or by binding to members of a ligand-containing complex.
synonym: "extracellular sequestering of receptor ligand" EXACT [GOC:bf]
synonym: "negative regulation of protein bioavailability" RELATED [GOC:BHF]
is_a: GO:1900116 ! extracellular negative regulation of signal transduction
created_by: rfoulger
creation_date: 2010-10-12T03:12:11Z

[Term]
id: GO:0035582
name: sequestering of BMP in extracellular matrix
namespace: biological_process
def: "Confining a bone morphogenetic protein (BMP) to the extracellular matrix (ECM), such that it is separated from other components of the signaling pathway, including its cell surface receptor. Bone morphogenetic proteins (BMPs) are secreted as homodimers, non-covalently associated with N-terminal pro-peptides, and are targeted to the extracellular matrix through interaction with matrix proteins." [GOC:BHF, PMID:20855508]
comment: Confining BMP in the extracellular matrix may be achieved by binding BMP directly, or by binding to members of a BMP-containing complex.
synonym: "BMP sequestration in the ECM" EXACT [PMID:20855508]
synonym: "negative regulation of BMP signaling pathway by extracellular sequestering of BMP" EXACT [GOC:bf]
synonym: "negative regulation of BMP signalling pathway by extracellular matrix sequestering of BMP" EXACT [GOC:mah]
synonym: "negative regulation of bone morphogenetic protein signaling pathway by extracellular matrix sequestering of bone morphogenetic protein" EXACT []
is_a: GO:0030514 ! negative regulation of BMP signaling pathway
is_a: GO:0035581 ! sequestering of extracellular ligand from receptor
is_a: GO:0071694 ! maintenance of protein location in extracellular region
created_by: rfoulger
creation_date: 2010-10-12T03:12:45Z

[Term]
id: GO:0035583
name: sequestering of TGFbeta in extracellular matrix
namespace: biological_process
def: "Confining TGFbeta to the extracellular matrix (ECM) such that it is separated from other components of the signaling pathway, including its cell surface receptor. TGFbeta is secreted as part of a latent complex that is targeted to the extracellular matrix through latent-TGFbeta-binding protein (LTBP)-mediated association with matrix proteins." [GOC:bf, GOC:BHF, GOC:signaling, PMID:12482908, PMID:20855508]
synonym: "negative regulation of transforming growth factor beta receptor signaling pathway by extracellular matrix sequestering of TGFbeta" EXACT [GOC:bf]
synonym: "negative regulation of transforming growth factor beta receptor signalling pathway by extracellular matrix sequestering of TGFbeta" EXACT [GOC:mah]
synonym: "sequestering of TGFbeta large latency complex in extracellular matrix" EXACT [PMID:12482908]
synonym: "sequestering of TGFbeta LLC in extracellular matrix" EXACT [PMID:12482908]
is_a: GO:0030512 ! negative regulation of transforming growth factor beta receptor signaling pathway
is_a: GO:0035581 ! sequestering of extracellular ligand from receptor
is_a: GO:0071694 ! maintenance of protein location in extracellular region
created_by: rfoulger
creation_date: 2010-10-12T03:13:29Z

[Term]
id: GO:0035584
name: calcium-mediated signaling using intracellular calcium source
namespace: biological_process
def: "A series of molecular signals in which a cell uses calcium ions released from an intracellular store to convert a signal into a response." [GOC:bf, GOC:BHF, PMID:20192754]
synonym: "calcium signaling using intracellular calcium source" EXACT []
synonym: "calcium signalling using intracellular calcium source" EXACT []
synonym: "calcium-mediated signalling using intracellular calcium source" EXACT []
is_a: GO:0019722 ! calcium-mediated signaling
created_by: rfoulger
creation_date: 2010-10-18T11:01:08Z

[Term]
id: GO:0035585
name: calcium-mediated signaling using extracellular calcium source
namespace: biological_process
def: "A series of molecular signals in which a cell uses calcium ions imported from an extracellular source to convert a signal into a response." [GOC:bf, GOC:BHF, PMID:20192754]
synonym: "calcium signaling using extracellular calcium source" EXACT []
synonym: "calcium signalling using extracellular calcium source" EXACT []
synonym: "calcium-mediated signalling using extracellular calcium source" EXACT []
synonym: "extracellular calcium influx" NARROW [GOC:BHF]
is_a: GO:0019722 ! calcium-mediated signaling
created_by: rfoulger
creation_date: 2010-10-18T11:04:27Z

[Term]
id: GO:0035586
name: purinergic receptor activity
namespace: molecular_function
def: "Combining with a purine or purine derivative (purine nucleoside or purine nucleotide) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule." [GOC:bf, GOC:BHF, GOC:signaling, PMID:9755289]
synonym: "purinoceptor" EXACT [PMID:9755289]
synonym: "purinoreceptor" EXACT [PMID:9755289]
is_a: GO:0004888 ! transmembrane signaling receptor activity
relationship: part_of GO:0035587 ! purinergic receptor signaling pathway
created_by: rfoulger
creation_date: 2010-10-22T10:57:12Z

[Term]
id: GO:0035587
name: purinergic receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a receptor binding to an extracellular purine or purine derivative to initiate a change in cell activity." [GOC:BHF, PMID:9755289]
synonym: "purinergic receptor signalling pathway" EXACT [GOC:mah]
synonym: "purinoceptor signaling pathway" EXACT [PMID:9755289]
is_a: GO:0007166 ! cell surface receptor signaling pathway
created_by: rfoulger
creation_date: 2010-10-22T11:09:40Z

[Term]
id: GO:0035588
name: G-protein coupled purinergic receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a receptor binding to an extracellular purine or purine derivative and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity." [GOC:BHF, PMID:9755289]
synonym: "G-protein coupled purinergic receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0007186 ! G-protein coupled receptor signaling pathway
is_a: GO:0035587 ! purinergic receptor signaling pathway
created_by: rfoulger
creation_date: 2010-10-22T11:11:53Z

[Term]
id: GO:0035589
name: G-protein coupled purinergic nucleotide receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a receptor binding to an extracellular purine nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity." [GOC:BHF, PMID:9755289]
synonym: "G-protein coupled purinergic nucleotide receptor signalling pathway" EXACT [GOC:mah]
synonym: "P2Y receptor signaling pathway" EXACT [PMID:9755289]
is_a: GO:0035588 ! G-protein coupled purinergic receptor signaling pathway
is_a: GO:0035590 ! purinergic nucleotide receptor signaling pathway
created_by: rfoulger
creation_date: 2010-10-22T11:18:59Z

[Term]
id: GO:0035590
name: purinergic nucleotide receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a receptor binding to an extracellular purine nucleotide to initiate a change in cell activity." [GOC:BHF, PMID:9755289]
synonym: "P2 receptor signaling pathway" RELATED [PMID:9755289]
synonym: "purinergic nucleotide receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0035587 ! purinergic receptor signaling pathway
created_by: rfoulger
creation_date: 2010-10-22T11:22:17Z

[Term]
id: GO:0035591
name: signaling adaptor activity
namespace: molecular_function
def: "The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity." [GOC:bf]
comment: A signaling adaptor can bring together both protein and non-protein molecules within a signaling pathway.
synonym: "signalling adaptor activity" EXACT [GOC:mah]
is_a: GO:0060090 ! binding, bridging
relationship: part_of GO:0009967 ! positive regulation of signal transduction
created_by: rfoulger
creation_date: 2010-11-05T11:22:01Z

[Term]
id: GO:0035592
name: establishment of protein localization to extracellular region
namespace: biological_process
def: "The directed movement of a protein to a specific location within the extracellular region." [GOC:bf, GOC:BHF]
synonym: "establishment of protein localisation in extracellular region" EXACT [GOC:mah]
synonym: "establishment of protein localization in extracellular region" EXACT [GOC:curators]
is_a: GO:0045184 ! establishment of protein localization
is_a: GO:1902578 ! single-organism localization
relationship: part_of GO:0071692 ! protein localization to extracellular region
created_by: rfoulger
creation_date: 2010-11-09T10:25:08Z

[Term]
id: GO:0035593
name: positive regulation of Wnt signaling pathway by establishment of Wnt protein localization to extracellular region
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the Wnt signaling pathway by the directed movement of a Wnt protein within the extracellular region." [GOC:BHF, PMID:19906850]
synonym: "positive regulation of Wnt diffusion" NARROW [PMID:19906850]
synonym: "positive regulation of Wnt receptor signaling pathway by establishment of Wnt protein localisation in extracellular region" EXACT [GOC:mah]
synonym: "positive regulation of Wnt receptor signaling pathway by establishment of Wnt protein localization in extracellular region" EXACT [GOC:curators]
synonym: "positive regulation of Wnt receptor signaling pathway by establishment of Wnt protein localization to extracellular region" EXACT []
synonym: "positive regulation of Wnt receptor signalling pathway by establishment of Wnt protein localization in extracellular region" EXACT [GOC:mah]
synonym: "positive regulation of Wnt signaling range" RELATED [PMID:19906850]
synonym: "positive regulation of Wnt-activated signaling pathway by establishment of Wnt protein localization to extracellular region" EXACT [GOC:signaling]
is_a: GO:0030177 ! positive regulation of Wnt signaling pathway
is_a: GO:0035592 ! establishment of protein localization to extracellular region
created_by: rfoulger
creation_date: 2010-11-09T10:29:44Z

[Term]
id: GO:0035594
name: ganglioside binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a ganglioside, a ceramide oligosaccharide carrying in addition to other sugar residues, one or more sialic acid residues." [GOC:yaf]
is_a: GO:0043208 ! glycosphingolipid binding
is_a: GO:0097001 ! ceramide binding
created_by: rfoulger
creation_date: 2010-11-11T02:11:38Z

[Term]
id: GO:0035595
name: N-acetylglucosaminylinositol deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O = 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + acetate. This reaction is the hydrolysis of an acetyl group from N-acetylglucosaminylinositol." [EC:3.5.1.103, GOC:rs]
synonym: "1-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol acetylhydrolase activity" EXACT [EC:3.5.1.103]
synonym: "1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase activity" EXACT [EC:3.5.1.103]
synonym: "GlcNAc-Ins deacetylase activity" EXACT [GOC:rs]
synonym: "N-acetyl-1D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase activity" EXACT [EC:3.5.1.103]
xref: EC:3.5.1.103
xref: KEGG:R09651
xref: MetaCyc:RXN1G-2
xref: RHEA:26183
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0019213 ! deacetylase activity
created_by: rfoulger
creation_date: 2010-11-11T02:12:48Z

[Term]
id: GO:0035596
name: methylthiotransferase activity
namespace: molecular_function
def: "Catalysis of the addition of a methylthioether group (-SCH3) to a nucleic acid or protein acceptor." [GOC:jh2, PMID:20472640]
synonym: "MTTase" EXACT [PMID:20472640]
is_a: GO:0050497 ! transferase activity, transferring alkylthio groups
created_by: rfoulger
creation_date: 2010-11-12T01:24:38Z

[Term]
id: GO:0035597
name: N6-isopentenyladenosine methylthiotransferase activity
namespace: molecular_function
def: "Catalysis of the methylthiolation (-SCH3 addition) at the C2 of the adenosine ring of N6-isopentenyladenosine (i6A) in tRNA, to form 2-methylthio-N6-isopentenyladenosine (ms2i6A)." [PMID:20472640]
synonym: "i6A methylthiotransferase activity" EXACT [PMID:20472640]
is_a: GO:0035596 ! methylthiotransferase activity
relationship: part_of GO:0035600 ! tRNA methylthiolation
created_by: rfoulger
creation_date: 2010-11-12T01:26:58Z

[Term]
id: GO:0035598
name: N6-threonylcarbomyladenosine methylthiotransferase activity
namespace: molecular_function
def: "Catalysis of the methylthiolation (-SCH3 addition) at the C2 of the adenosine ring of N6-threonylcarbomyladenosine (t6A) in tRNA, to form 2-methylthio-N6-threonylcarbamoyladenosine (ms2t6A)." [PMID:20472640, PMID:20584901]
synonym: "t6A methylthiotransferase activity" EXACT [PMID:20472640]
is_a: GO:0035596 ! methylthiotransferase activity
relationship: part_of GO:0035600 ! tRNA methylthiolation
created_by: rfoulger
creation_date: 2010-11-12T01:28:32Z

[Term]
id: GO:0035599
name: aspartic acid methylthiotransferase activity
namespace: molecular_function
def: "Catalysis of the methylthiolation (-SCH3 addition) of the beta-carbon of peptidyl-aspartic acid to form peptidyl-L-beta-methylthioaspartic acid." [PMID:18252828, PMID:8844851, RESID:AA0232]
comment: Note that peptidyl-L-beta-methylthioaspartic acid is typical of bacterial ribosomal protein S12.
xref: RESID:AA0232
is_a: GO:0035596 ! methylthiotransferase activity
relationship: part_of GO:0018339 ! peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid
created_by: rfoulger
creation_date: 2010-11-12T01:31:23Z

[Term]
id: GO:0035600
name: tRNA methylthiolation
namespace: biological_process
def: "The addition of a methylthioether group (-SCH3) to a nucleotide in a tRNA molecule." [PMID:20472640]
is_a: GO:0006400 ! tRNA modification
created_by: rfoulger
creation_date: 2010-11-12T01:34:02Z

[Term]
id: GO:0035601
name: protein deacylation
namespace: biological_process
def: "The removal of an acyl group, any group or radical of the form RCO- where R is an organic group, from a protein amino acid." [GOC:se, PMID:12080046]
synonym: "protein amino acid deacylation" EXACT [GOC:se]
is_a: GO:0006464 ! cellular protein modification process
is_a: GO:0098732 ! macromolecule deacylation
created_by: rfoulger
creation_date: 2010-11-15T11:06:15Z

[Term]
id: GO:0035602
name: fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands, which stops, prevents, or reduces the frequency, rate or extent of the occurrence or rate of cell death by apoptotic process in the bone marrow." [GOC:mtg_apoptosis, GOC:yaf]
synonym: "FGF receptor signaling pathway involved in negative regulation of apoptosis in bone marrow" EXACT [GOC:bf]
synonym: "FGFR signaling pathway involved in negative regulation of apoptosis in bone marrow" EXACT [GOC:bf]
synonym: "fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow" NARROW []
synonym: "fibroblast growth factor receptor signalling pathway involved in negative regulation of apoptotic process in bone marrow" EXACT [GOC:mah]
is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway
intersection_of: GO:0008543 ! fibroblast growth factor receptor signaling pathway
intersection_of: part_of GO:0071866 ! negative regulation of apoptotic process in bone marrow
relationship: part_of GO:0071866 ! negative regulation of apoptotic process in bone marrow
created_by: rfoulger
creation_date: 2010-11-15T11:09:20Z

[Term]
id: GO:0035603
name: fibroblast growth factor receptor signaling pathway involved in hemopoiesis
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands, which contributes to hemopoiesis." [GOC:yaf]
synonym: "FGF receptor signaling pathway involved in hematopoiesis" EXACT [GOC:bf]
synonym: "FGFR signaling pathway involved in hematopoiesis" EXACT [GOC:bf]
synonym: "fibroblast growth factor receptor signaling pathway involved in hematopoiesis" EXACT [GOC:yaf]
synonym: "fibroblast growth factor receptor signalling pathway involved in hemopoiesis" EXACT [GOC:mah]
is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway
intersection_of: GO:0008543 ! fibroblast growth factor receptor signaling pathway
intersection_of: part_of GO:0030097 ! hemopoiesis
relationship: part_of GO:0030097 ! hemopoiesis
created_by: rfoulger
creation_date: 2010-11-15T11:09:46Z

[Term]
id: GO:0035604
name: fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands, which activates or increases the frequency, rate or extent of cell proliferation in the bone marrow." [GOC:yaf]
synonym: "FGF receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow" EXACT [GOC:bf]
synonym: "FGFR signaling pathway involved in positive regulation of cell proliferation in bone marrow" EXACT [GOC:bf]
synonym: "fibroblast growth factor receptor signalling pathway involved in positive regulation of cell proliferation in bone marrow" EXACT [GOC:mah]
is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway
intersection_of: GO:0008543 ! fibroblast growth factor receptor signaling pathway
intersection_of: part_of GO:0071864 ! positive regulation of cell proliferation in bone marrow
relationship: part_of GO:0071864 ! positive regulation of cell proliferation in bone marrow
created_by: rfoulger
creation_date: 2010-11-15T11:10:14Z

[Term]
id: GO:0035605
name: peptidyl-cysteine S-nitrosylase activity
namespace: molecular_function
def: "Catalysis of the transfer of a nitric oxide (NO) group to a sulphur atom within a cysteine residue of a protein." [EC:2.6.99.-, GOC:sp, PMID:20972425, PMID:20972426]
comment: This term should not be used to annotate the nitrosylating action of nitric oxide synthase (NOS) if the nitroso group is synthesized directly on the substrate.
synonym: "protein nitrosylase activity" RELATED [GOC:sp]
synonym: "S-nitrosylase activity" EXACT [PMID:20972426]
is_a: GO:0016769 ! transferase activity, transferring nitrogenous groups
relationship: part_of GO:0018119 ! peptidyl-cysteine S-nitrosylation
created_by: rfoulger
creation_date: 2010-11-16T09:49:26Z

[Term]
id: GO:0035606
name: peptidyl-cysteine S-trans-nitrosylation
namespace: biological_process
def: "Transfer of a nitric oxide (NO) group from one cysteine residue to another." [PMID:19854201, PMID:20972425, PMID:20972426]
synonym: "cysteine to cysteine nitrosylation" EXACT [PMID:20972426]
synonym: "cysteine-to-cysteine transnitrosylation" EXACT [PMID:20972426]
synonym: "protein-to-protein transnitrosylation" BROAD [PMID:20972426]
synonym: "S-transnitrosylation" EXACT [PMID:20972426]
is_a: GO:0018119 ! peptidyl-cysteine S-nitrosylation
created_by: rfoulger
creation_date: 2010-11-16T09:54:46Z

[Term]
id: GO:0035607
name: fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a fibroblast growth factor-type receptor binding to one of its physiological ligands, which contributes to the progression of the orbitofrontal cortex over time from its initial formation until its mature state." [GOC:yaf]
synonym: "FGF receptor signaling pathway involved in orbitofrontal cortex development" EXACT [GOC:bf]
synonym: "FGFR signaling pathway involved in orbitofrontal cortex development" EXACT [GOC:bf]
synonym: "fibroblast growth factor receptor signalling pathway involved in orbitofrontal cortex development" EXACT [GOC:bf]
is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway
intersection_of: GO:0008543 ! fibroblast growth factor receptor signaling pathway
intersection_of: part_of GO:0021769 ! orbitofrontal cortex development
relationship: part_of GO:0021769 ! orbitofrontal cortex development
created_by: rfoulger
creation_date: 2010-11-16T11:30:19Z

[Term]
id: GO:0035608
name: protein deglutamylation
namespace: biological_process
def: "The removal of a glutamate residue from a protein. Glutamate residues in proteins can be gene-encoded, or added as side chains during the protein modification process of polyglutamylation." [GOC:sp, PMID:21074048]
synonym: "protein amino acid deglutamylation" EXACT [GOC:bf]
is_a: GO:0018200 ! peptidyl-glutamic acid modification
created_by: rfoulger
creation_date: 2010-11-18T01:04:38Z

[Term]
id: GO:0035609
name: C-terminal protein deglutamylation
namespace: biological_process
def: "The removal of a C-terminal, gene-encoded glutamate residue from a protein." [GOC:sp, PMID:21074048]
synonym: "protein primary sequence deglutamylation" EXACT [PMID:21074048]
is_a: GO:0018410 ! C-terminal protein amino acid modification
is_a: GO:0035608 ! protein deglutamylation
created_by: rfoulger
creation_date: 2010-11-18T01:06:00Z

[Term]
id: GO:0035610
name: protein side chain deglutamylation
namespace: biological_process
def: "The removal of a glutamate residue from the side chain of a protein. Glutamate side chains are added to glutamic acid residues within the primary protein sequence during polyglutamylation." [GOC:sp, PMID:21074048]
synonym: "removal of posttranslational polyglutamylation" EXACT [PMID:21074048]
synonym: "shortening of glutamate side chain" RELATED [PMID:21074048]
is_a: GO:0035608 ! protein deglutamylation
created_by: rfoulger
creation_date: 2010-11-18T01:09:03Z

[Term]
id: GO:0035611
name: protein branching point deglutamylation
namespace: biological_process
def: "The removal of a branching point glutamate residue. A branching point glutamate connects a glutamate side chain to a gene-encoded glutamate residue." [GOC:sp, PMID:21074048]
is_a: GO:0035608 ! protein deglutamylation
created_by: rfoulger
creation_date: 2010-11-18T01:11:21Z

[Term]
id: GO:0035612
name: AP-2 adaptor complex binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the AP-2 adaptor complex. The AP-2 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC)." [GOC:BHF, PMID:12221107, PMID:15728179, PMID:21097499]
synonym: "AP-2 clathrin adaptor complex binding" RELATED [GOC:bf]
is_a: GO:0032403 ! protein complex binding
created_by: rfoulger
creation_date: 2010-11-25T03:51:17Z

[Term]
id: GO:0035613
name: RNA stem-loop binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a stem-loop in an RNA molecule. An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop." [GOC:sart, PMID:16568238, PMID:20455544]
synonym: "RNA hairpin binding" EXACT [PMID:16568238]
synonym: "RNA hairpin loop binding" EXACT [PMID:16568238]
is_a: GO:0003723 ! RNA binding
created_by: rfoulger
creation_date: 2010-11-26T10:41:49Z

[Term]
id: GO:0035614
name: snRNA stem-loop binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a stem-loop in a small nuclear RNA (snRNA). An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop." [GOC:sart, PMID:16568238, PMID:20455544]
synonym: "small nuclear RNA stem-loop binding" EXACT []
synonym: "snRNA hairpin binding" EXACT [PMID:16568238]
synonym: "snRNA hairpin loop binding" EXACT [PMID:16568238]
is_a: GO:0017069 ! snRNA binding
is_a: GO:0035613 ! RNA stem-loop binding
created_by: rfoulger
creation_date: 2010-11-26T10:43:17Z

[Term]
id: GO:0035615
name: clathrin adaptor activity
namespace: molecular_function
def: "The binding activity of a molecule that brings together clathrin and one or more other molecules, permitting them to function in a coordinated way." [GOC:BHF, PMID:15728179]
synonym: "clathrin-associated adaptor activity" EXACT [PMID:15728179]
is_a: GO:0030276 ! clathrin binding
is_a: GO:0098748 ! endocytic adaptor activity
created_by: rfoulger
creation_date: 2010-12-01T11:17:57Z

[Term]
id: GO:0035616
name: histone H2B conserved C-terminal lysine deubiquitination
namespace: biological_process
def: "A histone deubiquitination process in which a ubiquitin monomer is removed from a conserved lysine residue in the C-terminus of histone H2B. The conserved lysine residue is K119 in fission yeast, K123 in budding yeast, or K120 in mammals." [GOC:bf, GOC:vw, PMID:15657442]
synonym: "budding yeast H2B K123 deubiquitination" NARROW [GOC:vw]
synonym: "fission yeast H2B K119 deubiquitination" NARROW [GOC:vw]
synonym: "mammalian H2B K120 deubiquitination" NARROW [GOC:vw]
is_a: GO:0016578 ! histone deubiquitination
created_by: rfoulger
creation_date: 2010-12-03T10:36:44Z

[Term]
id: GO:0035617
name: stress granule disassembly
namespace: biological_process
def: "The disaggregation of a stress granule into its constituent protein and RNA parts." [GOC:BHF, PMID:19825938]
synonym: "SG disassembly" EXACT [PMID:19825938]
is_a: GO:0032988 ! ribonucleoprotein complex disassembly
is_a: GO:1903008 ! organelle disassembly
created_by: rfoulger
creation_date: 2010-12-03T10:38:57Z

[Term]
id: GO:0035618
name: root hair
namespace: cellular_component
def: "A long, thin projection from a root epidermal cell that contains F-actin and tubulin, and a cell wall." [http://www.jstor.org/stable/4354264, PO:0000256]
comment: This term is a child of 'cell projection' and not 'cell hair' to distinguish it from animal cell hairs, which are morphologically distinct.
is_a: GO:0042995 ! cell projection
created_by: rfoulger
creation_date: 2010-12-03T01:42:40Z

[Term]
id: GO:0035619
name: root hair tip
namespace: cellular_component
def: "The tip portion of an outgrowth of a root epidermal cell." [PO:0000029]
synonym: "root hair cell tip" EXACT []
is_a: GO:0044463 ! cell projection part
relationship: part_of GO:0035618 ! root hair
created_by: rfoulger
creation_date: 2010-12-03T01:43:55Z

[Term]
id: GO:0035620
name: ceramide transporter activity
namespace: molecular_function
def: "Enables the directed movement of ceramides into, out of or within a cell, or between cells. Ceramides are a class of lipid composed of sphingosine linked to a fatty acid." [GOC:sart, PMID:14685229]
is_a: GO:0046624 ! sphingolipid transporter activity
relationship: part_of GO:0035627 ! ceramide transport
created_by: rfoulger
creation_date: 2010-12-08T12:32:50Z

[Term]
id: GO:0035621
name: ER to Golgi ceramide transport
namespace: biological_process
def: "The directed movement of a ceramide from the endoplasmic reticulum (ER) to the Golgi. Ceramides are a class of lipid composed of sphingosine linked to a fatty acid." [GOC:sart, PMID:14685229]
synonym: "endoplasmic reticulum to Golgi ceramide transport" EXACT [GOC:bf]
synonym: "ER to Golgi ceramide translocation" EXACT [PMID:14685229]
synonym: "non-vesicular ceramide trafficking" EXACT [PMID:14685229]
is_a: GO:0032365 ! intracellular lipid transport
is_a: GO:0035627 ! ceramide transport
created_by: rfoulger
creation_date: 2010-12-08T12:36:35Z

[Term]
id: GO:0035622
name: intrahepatic bile duct development
namespace: biological_process
def: "The progression of the intrahepatic bile ducts over time, from their formation to the mature structure. Intrahepatic bile ducts (bile ducts within the liver) collect bile from bile canaliculi in the liver, and connect to the extrahepatic bile ducts (bile ducts outside the liver)." [GOC:bf, PMID:20614624]
synonym: "IHBD development" EXACT [PMID:20614624]
synonym: "intrahepatic biliary duct development" EXACT [PMID:20614624]
is_a: GO:0061009 ! common bile duct development
relationship: part_of GO:0001889 ! liver development
created_by: rfoulger
creation_date: 2010-12-08T04:10:50Z

[Term]
id: GO:0035623
name: renal glucose absorption
namespace: biological_process
def: "A renal system process in which glucose is taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures." [GOC:yaf, PMID:11269503]
synonym: "glucose reabsorption" EXACT [GOC:yaf]
synonym: "nephron glucose absorption" EXACT [GOC:yaf]
is_a: GO:0015758 ! glucose transport
is_a: GO:0044707 ! single-multicellular organism process
is_a: GO:0070293 ! renal absorption
created_by: rfoulger
creation_date: 2010-12-08T04:14:23Z

[Term]
id: GO:0035624
name: receptor transactivation
namespace: biological_process
def: "The process in which a receptor is activated by another receptor. Receptor transactivation can occur through different mechanisms and includes cross-talk between signaling pathways where one receptor activates a receptor for a different ligand, and also activation of subunits within a receptor oligomer." [GOC:al, GOC:bf, GOC:BHF, PMID:16870826, PMID:21063387]
is_a: GO:2000273 ! positive regulation of receptor activity
created_by: rfoulger
creation_date: 2010-12-08T04:18:18Z

[Term]
id: GO:0035625
name: epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
namespace: biological_process
def: "The process in which an epidermal growth factor-activated receptor is activated via signaling events from a G-protein coupled receptor. This is an example of cross-talk between the EGF and GPCR signaling pathways." [GOC:bf, GOC:BHF, PMID:10622253, PMID:17655843]
synonym: "EGFR transactivation by GPCR" EXACT [GOC:bf]
synonym: "EGFR transactivation upon GPCR stimulation" EXACT [PMID:10622253]
synonym: "epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway" EXACT [GOC:bf, GOC:signaling]
synonym: "epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0007186 ! G-protein coupled receptor signaling pathway
is_a: GO:0035624 ! receptor transactivation
is_a: GO:0045741 ! positive regulation of epidermal growth factor-activated receptor activity
created_by: rfoulger
creation_date: 2010-12-08T04:19:12Z

[Term]
id: GO:0035626
name: juvenile hormone mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of juvenile hormone to a receptor, and ending with regulation of cell state or activity." [GOC:bf, GOC:sart]
synonym: "juvenile hormone mediated signalling pathway" EXACT [GOC:bf]
synonym: "juvenile hormone-mediated signaling pathway" EXACT [GOC:bf]
is_a: GO:0009755 ! hormone-mediated signaling pathway
is_a: GO:0030522 ! intracellular receptor signaling pathway
created_by: rfoulger
creation_date: 2010-12-08T04:45:25Z

[Term]
id: GO:0035627
name: ceramide transport
namespace: biological_process
def: "The directed movement of ceramides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ceramides are a class of lipid composed of sphingosine linked to a fatty acid." [GOC:bf, GOC:sart]
is_a: GO:0006869 ! lipid transport
is_a: GO:0042886 ! amide transport
created_by: rfoulger
creation_date: 2010-12-10T10:02:16Z

[Term]
id: GO:0035628
name: cystic duct development
namespace: biological_process
def: "The progression of the cystic duct over time, from its formation to the mature structure. The cystic duct runs from the gall bladder to the common bile duct." [PMID:20614624]
is_a: GO:0061009 ! common bile duct development
relationship: part_of GO:0061008 ! hepaticobiliary system development
created_by: rfoulger
creation_date: 2010-12-10T01:24:28Z

[Term]
id: GO:0035629
name: N-terminal protein amino acid N-linked glycosylation
namespace: biological_process
def: "Addition of a carbohydrate or carbohydrate derivative unit via a nitrogen (N) atom of the N-terminal amino acid of a protein." [GOC:bf, GOC:pr]
comment: Note that the only known alpha amino glycosylation is on an asparagine; see UniProtKB:P58522. However, this feature is not differentiated from normal N-glycosylation of asparagine.
is_a: GO:0006487 ! protein N-linked glycosylation
is_a: GO:0031365 ! N-terminal protein amino acid modification
created_by: rfoulger
creation_date: 2010-12-17T10:45:48Z

[Term]
id: GO:0035630
name: bone mineralization involved in bone maturation
namespace: biological_process
def: "The deposition of hydroxyapatite, involved in the progression of the skeleton from its formation to its mature state." [GOC:bf, GOC:BHF]
comment: Bone mineralization can also occur after a fracture and as a response to stress; in these cases, consider using the term 'bone mineralization ; GO:0030282'.
is_a: GO:0030282 ! bone mineralization
intersection_of: GO:0030282 ! bone mineralization
intersection_of: part_of GO:0043931 ! ossification involved in bone maturation
relationship: part_of GO:0043931 ! ossification involved in bone maturation
created_by: rfoulger
creation_date: 2010-12-20T01:57:31Z

[Term]
id: GO:0035631
name: CD40 receptor complex
namespace: cellular_component
def: "A protein complex that contains at least CD40 (a cell surface receptor of the tumour necrosis factor receptor (TNFR) superfamily), and other signaling molecules." [GOC:BHF, PMID:20614026, PMID:9221764]
is_a: GO:0098802 ! plasma membrane receptor complex
relationship: part_of GO:0005887 ! integral component of plasma membrane
created_by: rfoulger
creation_date: 2010-12-21T10:35:05Z

[Term]
id: GO:0035632
name: mitochondrial prohibitin complex
namespace: cellular_component
def: "A complex composed of two proteins, prohibitin 1 and prohibitin 2 (PHB1/PHB-1 and PHB2/PHB-2) that is highly conserved amongst eukaryotes and associated with the inner mitochondrial membrane. The mitochondrial prohibitin complex is a macromolecular supercomplex composed of repeating heterodimeric subunits of PHB1 and PHB2. The mitochondrial prohibitin complex plays a role in a number of biological processes, including mitochondrial biogenesis and function, development, replicative senescence, and cell death." [GOC:kmv, PMID:12237468, PMID:21164222]
synonym: "mitochondrial inner membrane prohibitin complex" EXACT [GOC:bf]
is_a: GO:0098800 ! inner mitochondrial membrane protein complex
relationship: part_of GO:0005743 ! mitochondrial inner membrane
created_by: rfoulger
creation_date: 2010-12-21T10:38:59Z

[Term]
id: GO:0035633
name: maintenance of blood-brain barrier
namespace: biological_process
def: "Preserving the permeability barrier between the blood and the brain in a stable functional or structural state. The cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier." [GOC:bf, GOC:sl, PMID:20080302]
synonym: "maintenance of BBB" EXACT [PMID:20080302]
is_a: GO:0044763 ! single-organism cellular process
created_by: rfoulger
creation_date: 2011-01-07T10:33:11Z

[Term]
id: GO:0035634
name: response to stilbenoid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of exposure to a stilbenoid. Stilbenoids are secondary products of heartwood formation in trees that can act as phytoalexins. Stilbenoids are hydroxylated derivatives of stilbene. They belong to the family of phenylpropanoids and share most of their biosynthesis pathway with chalcones." [CHEBI:26776, GOC:yaf, Wikipedia:Stilbenoid]
subset: goslim_chembl
is_a: GO:0080184 ! response to phenylpropanoid
created_by: rfoulger
creation_date: 2011-01-12T10:37:33Z

[Term]
id: GO:0035635
name: entry of bacterium into host cell
namespace: biological_process
def: "The process in which a bacterium enters a host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:bf, PMID:21187937]
synonym: "bacterial entry into host cell" EXACT [GOC:bf]
synonym: "invasion of bacteria into host cell" EXACT [GOC:bf]
is_a: GO:0030260 ! entry into host cell
created_by: rfoulger
creation_date: 2011-01-13T02:26:54Z

[Term]
id: GO:0035636
name: multi-organism signaling
namespace: biological_process
def: "The transfer of information between living organisms." [GOC:go_curators]
synonym: "multi-organism signalling" EXACT [GOC:bf]
synonym: "pheromone signaling" NARROW [GOC:bf]
synonym: "signaling between organisms" EXACT [GOC:bf]
synonym: "signaling with other organism" EXACT [GOC:bf]
is_a: GO:0023052 ! signaling
is_a: GO:0051704 ! multi-organism process
created_by: rfoulger
creation_date: 2011-01-14T10:11:25Z

[Term]
id: GO:0035637
name: multicellular organismal signaling
namespace: biological_process
def: "The transfer of information occurring at the level of a multicellular organism." [GOC:go_curators]
synonym: "multicellular organismal signalling" EXACT [GOC:bf]
is_a: GO:0044700 ! single organism signaling
is_a: GO:0044707 ! single-multicellular organism process
created_by: rfoulger
creation_date: 2011-01-14T10:13:50Z

[Term]
id: GO:0035638
name: signal maturation
namespace: biological_process
def: "Any process leading to the attainment of the full functional capacity of a signal. A signal is a physical entity or change in state that is used to transfer information to trigger a response, and is functional when it can activate a receptor." [GOC:bf, GOC:pde, GOC:signaling]
synonym: "ligand maturation" NARROW [GOC:bf]
is_a: GO:0044763 ! single-organism cellular process
relationship: part_of GO:0023056 ! positive regulation of signaling
created_by: rfoulger
creation_date: 2011-01-14T10:38:33Z

[Term]
id: GO:0035639
name: purine ribonucleoside triphosphate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [CHEBI:26398, GOC:BHF, GOC:ebc, ISBN:0198506732]
synonym: "purine NTP binding" BROAD [GOC:ebc]
is_a: GO:0043168 ! anion binding
is_a: GO:1901265 ! nucleoside phosphate binding
created_by: rfoulger
creation_date: 2011-01-14T02:46:42Z

[Term]
id: GO:0035640
name: exploration behavior
namespace: biological_process
def: "The specific behavior of an organism in response to a novel environment or stimulus." [GOC:BHF, GOC:pr, PMID:11682103, PMID:9767169]
comment: For changes in locomotory behavior upon introduction to a novel environment, consider instead the child term: locomotory exploration behavior ; GO:0035641.
synonym: "exploration behaviour" EXACT [GOC:bf]
synonym: "exploratory behavior" EXACT [PMID:20869398]
synonym: "exploratory behaviour" EXACT [PMID:11682103]
synonym: "open-field behavior" NARROW [PMID:11682103]
is_a: GO:0044708 ! single-organism behavior
created_by: rfoulger
creation_date: 2011-01-19T10:35:45Z

[Term]
id: GO:0035641
name: locomotory exploration behavior
namespace: biological_process
def: "The specific movement from place to place of an organism in response to a novel environment." [GOC:sart, PMID:17151232]
is_a: GO:0007626 ! locomotory behavior
is_a: GO:0035640 ! exploration behavior
created_by: rfoulger
creation_date: 2011-01-19T10:40:04Z

[Term]
id: GO:0035642
name: histone methyltransferase activity (H3-R17 specific)
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 17) = S-adenosyl-L-homocysteine + (histone H3)-N-methyl-arginine (position 17). This reaction is the addition of a methyl group to arginine at position 17 of histone H3." [GOC:sp, PMID:11341840]
synonym: "histone methylase activity (H3-R17 specific)" EXACT [GOC:bf]
synonym: "histone-arginine N-methyltransferase activity (H3-R17 specific)" EXACT [GOC:bf]
is_a: GO:0008469 ! histone-arginine N-methyltransferase activity
relationship: part_of GO:0034971 ! histone H3-R17 methylation
created_by: rfoulger
creation_date: 2011-01-19T10:41:43Z

[Term]
id: GO:0035643
name: L-DOPA receptor activity
namespace: molecular_function
def: "Combining with L-DOPA to initiate a change in cell activity. L-DOPA is the modified amino acid (2S)-2-amino-3-(3,4-dihydroxyphenyl) propanoic acid, and is the precursor to dopamine, norepinephrine (noradrenaline) and epinephrine." [CHEBI:15765, PMID:18828673, Wikipedia:L-DOPA]
synonym: "L-beta-(3,4-Dihydroxyphenyl)alanine receptor activity" EXACT [CHEBI:15765]
synonym: "L-dopa receptor activity" EXACT [CHEBI:15765]
is_a: GO:0008188 ! neuropeptide receptor activity
relationship: has_part GO:0072544 ! L-DOPA binding
created_by: rfoulger
creation_date: 2011-01-20T10:34:23Z

[Term]
id: GO:0035644
name: phosphoanandamide dephosphorylation
namespace: biological_process
def: "The process of removing one or more phosphate groups from a phosphorylated anandamide." [CHEBI:2700, GOC:BHF, PMID:16938887]
is_a: GO:0016311 ! dephosphorylation
created_by: rfoulger
creation_date: 2011-01-21T02:14:04Z

[Term]
id: GO:0035645
name: enteric smooth muscle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell of the intestine." [CL:0002504, GOC:BHF]
synonym: "intestinal smooth muscle cell differentiation" EXACT [CL:0002504]
is_a: GO:0051145 ! smooth muscle cell differentiation
relationship: part_of GO:0048565 ! digestive tract development
created_by: rfoulger
creation_date: 2011-01-21T02:58:58Z

[Term]
id: GO:0035646
name: endosome to melanosome transport
namespace: biological_process
def: "The directed movement of substances from endosomes to the melanosome, a specialised lysosome-related organelle." [PMID:16162817]
is_a: GO:0043485 ! endosome to pigment granule transport
created_by: rfoulger
creation_date: 2011-01-24T01:30:07Z

[Term]
id: GO:0035647
name: 3-oxo-delta(4,5)-steroid 5-beta-reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 3-oxo-delta-4,5-steroid + NADPH + H(+) = a 5-beta-3-oxo-steroid + NADP(+)." [GOC:kad, MetaCyc:RXN-9726, PMID:19166903]
synonym: "3-oxo-delta4,5-steroid 5beta-reductase" EXACT [GOC:kad]
is_a: GO:0035671 ! enone reductase activity
created_by: rfoulger
creation_date: 2011-01-24T01:31:30Z

[Term]
id: GO:0035648
name: circadian mating behavior
namespace: biological_process
def: "The fluctuation in mating behavior that occurs over an approximately 24 hour cycle." [GOC:bf, GOC:dos, PMID:11470898, PMID:17276917]
synonym: "circadian mating behaviour" EXACT [GOC:bf]
synonym: "circadian mating rhythm" EXACT [GOC:dos]
is_a: GO:0007617 ! mating behavior
is_a: GO:0048512 ! circadian behavior
created_by: rfoulger
creation_date: 2011-01-25T10:20:05Z

[Term]
id: GO:0035649
name: Nrd1 complex
namespace: cellular_component
def: "A complex that functions in transcription termination of RNA polymerase II transcribed non-coding RNAs. This complex interacts with the carboxy-terminal domain (CTD) of PolII and the terminator sequences in the nascent RNA transcript. In yeast this complex consists of Nrd1p, Nab3p, and Sen1p." [GOC:jh, PMID:10655211, PMID:16427013, PMID:21084293]
is_a: GO:0043234 ! protein complex
created_by: rfoulger
creation_date: 2011-01-25T10:23:25Z

[Term]
id: GO:0035650
name: AP-1 adaptor complex binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the AP-1 adaptor complex. The AP-1 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C)." [PMID:21097499]
is_a: GO:0032403 ! protein complex binding
created_by: rfoulger
creation_date: 2011-01-25T10:58:52Z

[Term]
id: GO:0035651
name: AP-3 adaptor complex binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the AP-3 adaptor complex. The AP-3 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B)." [PMID:21097499]
is_a: GO:0032403 ! protein complex binding
created_by: rfoulger
creation_date: 2011-01-25T10:59:36Z

[Term]
id: GO:0035652
name: cargo loading into clathrin-coated vesicle
namespace: biological_process
def: "Formation of a protein complex between the cytoplasmic coat proteins on clathrin-coated vesicles and proteins that are going to be transported by a vesicle." [PMID:16162817]
is_a: GO:0035459 ! cargo loading into vesicle
created_by: rfoulger
creation_date: 2011-01-25T11:00:43Z

[Term]
id: GO:0035653
name: cargo loading into clathrin-coated vesicle, AP-1-mediated
namespace: biological_process
def: "Formation of a protein complex between proteins of the AP-1 adaptor complex and proteins that are going to be transported by a clathrin-coated vesicle. The AP-1 adaptor protein complex is a component of the cytoplasmic coat found on clathrin-coated vesicles, and binds to sorting signals of cargo to facilitate their trafficking." [PMID:12802059, PMID:16162817]
is_a: GO:0035652 ! cargo loading into clathrin-coated vesicle
created_by: rfoulger
creation_date: 2011-01-25T11:01:38Z

[Term]
id: GO:0035654
name: cargo loading into clathrin-coated vesicle, AP-3-mediated
namespace: biological_process
def: "Formation of a protein complex between proteins of the AP-3 adaptor complex and proteins that are going to be transported by a clathrin-coated vesicle. In some cases, The AP-3 complex is a heterotetrameric AP-type membrane coat adaptor complex that, in some organisms, links clathrin to the membrane surface of a vesicle." [PMID:12802059, PMID:16162817]
is_a: GO:0035652 ! cargo loading into clathrin-coated vesicle
created_by: rfoulger
creation_date: 2011-01-25T11:02:30Z

[Term]
id: GO:0035655
name: interleukin-18-mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of interleukin-18 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:BHF, GOC:signaling]
synonym: "interleukin-18-mediated signalling pathway" EXACT [GOC:bf]
is_a: GO:0019221 ! cytokine-mediated signaling pathway
relationship: part_of GO:0071351 ! cellular response to interleukin-18
created_by: rfoulger
creation_date: 2011-01-26T09:55:57Z

[Term]
id: GO:0035656
name: kinesin-associated melanosomal adaptor activity
namespace: molecular_function
def: "The activity of linking kinesins, cytoplasmic proteins responsible for moving vesicles and organelles towards the distal end of microtubules, to melanosomes." [PMID:19841138]
synonym: "kinesin-melanosome adaptor activity" EXACT [GOC:bf]
is_a: GO:0019894 ! kinesin binding
is_a: GO:0030674 ! protein binding, bridging
created_by: rfoulger
creation_date: 2011-01-27T01:32:51Z

[Term]
id: GO:0035657
name: eRF1 methyltransferase complex
namespace: cellular_component
def: "A protein complex required for the methylation of a glutamine (Gln) residue in the protein release factor eRF1. In S. cerevisiae, this complex consists of at least Trm112p and Mtq2p." [GOC:rb, PMID:17008308, PMID:20400505]
synonym: "eRF1 MTase complex" EXACT [PMID:17008308]
is_a: GO:0034708 ! methyltransferase complex
created_by: rfoulger
creation_date: 2011-01-28T11:29:40Z

[Term]
id: GO:0035658
name: Mon1-Ccz1 complex
namespace: cellular_component
def: "A protein complex that functions as a guanine nucleotide exchange factor (GEF) and converts Rab-GDP to Rab-GTP. In S. cerevisiae, this complex consists of at least Mon1 and Ccz1, and serves as a GEF for the Rab Ypt7p." [GOC:rb, PMID:20797862]
is_a: GO:0043234 ! protein complex
is_a: GO:0044440 ! endosomal part
relationship: part_of GO:0005770 ! late endosome
created_by: rfoulger
creation_date: 2011-01-28T11:31:20Z

[Term]
id: GO:0035659
name: Wnt signaling pathway involved in wound healing, spreading of epidermal cells
namespace: biological_process
def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of a cell in the epidermis that contributes to the migration of an epidermal cell along or through a wound gap to reestablish a continuous epidermis." [GOC:BHF]
synonym: "Wnt receptor signaling pathway involved in wound healing, spreading of epidermal cells" EXACT []
synonym: "Wnt receptor signalling pathway involved in wound healing, spreading of epidermal cells" EXACT [GOC:mah]
synonym: "Wnt-activated signaling pathway involved in wound healing, spreading of epidermal cells" EXACT [GOC:signaling]
is_a: GO:0016055 ! Wnt signaling pathway
intersection_of: GO:0016055 ! Wnt signaling pathway
intersection_of: part_of GO:0035313 ! wound healing, spreading of epidermal cells
relationship: part_of GO:0035313 ! wound healing, spreading of epidermal cells
created_by: rfoulger
creation_date: 2011-01-28T11:34:02Z

[Term]
id: GO:0035660
name: MyD88-dependent toll-like receptor 4 signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to a toll-like 4 receptor, where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like 4 receptors bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response." [GOC:BHF, PMID:18304834, PMID:20385024]
synonym: "MyD88-dependent TLR4 signaling pathway" EXACT [GOC:bf]
synonym: "MyD88-dependent toll-like receptor 4 signalling pathway" EXACT [GOC:bf]
is_a: GO:0002755 ! MyD88-dependent toll-like receptor signaling pathway
is_a: GO:0034142 ! toll-like receptor 4 signaling pathway
created_by: rfoulger
creation_date: 2011-02-01T10:10:04Z

[Term]
id: GO:0035661
name: MyD88-dependent toll-like receptor 2 signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to a toll-like 2 receptor where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like 2 receptors are pattern recognition receptors that bind microbial pattern motifs to initiate an innate immune response." [GOC:BHF, PMID:20385024]
synonym: "MyD88-dependent TLR2 signaling pathway" EXACT [GOC:bf]
synonym: "MyD88-dependent toll-like receptor 2 signalling pathway" EXACT [GOC:bf]
is_a: GO:0002755 ! MyD88-dependent toll-like receptor signaling pathway
is_a: GO:0034134 ! toll-like receptor 2 signaling pathway
created_by: rfoulger
creation_date: 2011-02-01T10:11:01Z

[Term]
id: GO:0035662
name: Toll-like receptor 4 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a Toll-like 4 protein, a pattern recognition receptor that binds bacterial lipopolysaccharide (LPS) to initiate an innate immune response." [GOC:BHF, PMID:18304834]
synonym: "TLR4 binding" EXACT [GOC:bf]
is_a: GO:0035325 ! Toll-like receptor binding
created_by: rfoulger
creation_date: 2011-02-01T10:20:59Z

[Term]
id: GO:0035663
name: Toll-like receptor 2 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a Toll-like 2 protein, a pattern recognition receptor that binds microbial pattern motifs to initiate an innate immune response." [GOC:BHF]
synonym: "TLR2 binding" EXACT [GOC:bf]
is_a: GO:0035325 ! Toll-like receptor binding
created_by: rfoulger
creation_date: 2011-02-01T10:21:51Z

[Term]
id: GO:0035664
name: TIRAP-dependent toll-like receptor signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the TIRAP/MAL adaptor mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response." [GOC:BHF, PMID:11526399, PMID:11544529, PMID:12447442]
synonym: "MAL-dependent toll-like receptor signaling pathway" EXACT [PMID:11544529]
synonym: "MyD88 adapter-like dependent toll-like receptor signaling pathway" EXACT [PMID:11544529]
synonym: "TIRAP-dependent TLR signaling pathway" EXACT [GOC:bf]
synonym: "TIRAP-dependent toll-like receptor signalling pathway" EXACT [GOC:bf]
is_a: GO:0002224 ! toll-like receptor signaling pathway
created_by: rfoulger
creation_date: 2011-02-01T02:31:37Z

[Term]
id: GO:0035665
name: TIRAP-dependent toll-like receptor 4 signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor 4 where the TIRAP/MAL adaptor mediates transduction of the signal. Toll-like 4 receptors are pattern recognition receptors that bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response." [GOC:BHF, PMID:12447441]
synonym: "MAL-dependent toll-like receptor 4 signaling pathway" EXACT [PMID:11544529]
synonym: "MyD88 adapter-like dependent toll-like receptor 4 signaling pathway" EXACT [GOC:11544529]
synonym: "TIRAP-dependent TLR4 signaling pathway" EXACT [GOC:bf]
synonym: "TIRAP-dependent toll-like receptor 4 signalling pathway" EXACT [GOC:bf]
is_a: GO:0034142 ! toll-like receptor 4 signaling pathway
is_a: GO:0035664 ! TIRAP-dependent toll-like receptor signaling pathway
created_by: rfoulger
creation_date: 2011-02-01T02:33:48Z

[Term]
id: GO:0035666
name: TRIF-dependent toll-like receptor signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the TRIF adaptor mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response." [GOC:BHF, PMID:12855817]
synonym: "Toll/IL-1 receptor (TIR) domain-containing adaptor-dependent TLR signaling pathway" EXACT [PMID:12855817]
synonym: "TRIF-dependent TLR signaling pathway" EXACT [GOC:bf]
synonym: "TRIF-dependent toll-like receptor signalling pathway" EXACT [GOC:bf]
xref: Reactome:REACT_111135 "TRIF mediated TLR3 signaling, Homo sapiens"
xref: Reactome:REACT_111936 "TRIF mediated TLR3 signaling, Schizosaccharomyces pombe"
xref: Reactome:REACT_112079 "TRIF mediated TLR3 signaling, Caenorhabditis elegans"
xref: Reactome:REACT_112508 "TRIF mediated TLR3 signaling, Taeniopygia guttata"
xref: Reactome:REACT_112658 "TRIF mediated TLR3 signaling, Xenopus tropicalis"
xref: Reactome:REACT_112958 "TRIF mediated TLR3 signaling, Danio rerio"
xref: Reactome:REACT_113472 "TRIF mediated TLR3 signaling, Sus scrofa"
xref: Reactome:REACT_113475 "TRIF mediated TLR3 signaling, Oryza sativa"
xref: Reactome:REACT_113731 "TRIF mediated TLR3 signaling, Gallus gallus"
xref: Reactome:REACT_113758 "TRIF mediated TLR3 signaling, Dictyostelium discoideum"
xref: Reactome:REACT_114089 "TRIF mediated TLR3 signaling, Canis familiaris"
xref: Reactome:REACT_114251 "TRIF mediated TLR3 signaling, Saccharomyces cerevisiae"
xref: Reactome:REACT_114313 "TRIF mediated TLR3 signaling, Drosophila melanogaster"
xref: Reactome:REACT_114629 "TRIF mediated TLR3 signaling, Mus musculus"
xref: Reactome:REACT_114730 "TRIF mediated TLR3 signaling, Bos taurus"
xref: Reactome:REACT_115269 "TRIF mediated TLR3 signaling, Rattus norvegicus"
xref: Reactome:REACT_115453 "TRIF mediated TLR3 signaling, Arabidopsis thaliana"
is_a: GO:0002756 ! MyD88-independent toll-like receptor signaling pathway
created_by: rfoulger
creation_date: 2011-02-01T02:35:35Z

[Term]
id: GO:0035667
name: TRIF-dependent toll-like receptor 4 signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to a toll-like 4 receptor where the TRIF adaptor mediates transduction of the signal. Toll-like 4 receptors are pattern recognition receptors that bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response." [GOC:BHF, PMID:18641322, PMID:20511708]
synonym: "Toll/IL-1 receptor (TIR) domain-containing adaptor-dependent TLR4 signaling pathway" EXACT [PMID:12855817]
synonym: "TRIF-dependent TLR4 signaling pathway" EXACT [GOC:bf]
synonym: "TRIF-dependent toll-like receptor 4 signalling pathway" EXACT [GOC:bf]
is_a: GO:0034142 ! toll-like receptor 4 signaling pathway
is_a: GO:0035666 ! TRIF-dependent toll-like receptor signaling pathway
created_by: rfoulger
creation_date: 2011-02-01T02:37:25Z

[Term]
id: GO:0035668
name: TRAM-dependent toll-like receptor signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the TRAM adaptor mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response." [GOC:BHF, PMID:14556004]
synonym: "TRAM-dependent TLR signaling pathway" EXACT [GOC:bf]
synonym: "TRAM-dependent toll-like receptor signalling pathway" EXACT [GOC:bf]
is_a: GO:0002756 ! MyD88-independent toll-like receptor signaling pathway
created_by: rfoulger
creation_date: 2011-02-01T02:39:34Z

[Term]
id: GO:0035669
name: TRAM-dependent toll-like receptor 4 signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor 4 where the TRAM adaptor mediates transduction of the signal. Toll-like 4 receptors are pattern recognition receptors that bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response." [GOC:BHF, PMID:14556004, PMID:18297073]
synonym: "TRAM-dependent TLR4 signaling pathway" EXACT [GOC:bf]
synonym: "TRAM-dependent toll-like receptor 4 signalling pathway" EXACT [GOC:bf]
is_a: GO:0034142 ! toll-like receptor 4 signaling pathway
is_a: GO:0035668 ! TRAM-dependent toll-like receptor signaling pathway
created_by: rfoulger
creation_date: 2011-02-01T02:41:09Z

[Term]
id: GO:0035670
name: plant-type ovary development
namespace: biological_process
def: "The process whose specific outcome is the progression of an ovary that produces an ovule over time, from its formation to the mature structure. The ovary is the enlarged basal portion of a carpel and matures into a fruit. An ovule is the multicellular structure that gives rise to and contains the female reproductive cells, and develops into a seed." [GOC:bf, GOC:tb, ISBN:0879015322]
is_a: GO:0048608 ! reproductive structure development
relationship: part_of GO:0048440 ! carpel development
created_by: rfoulger
creation_date: 2011-02-04T09:35:05Z

[Term]
id: GO:0035671
name: enone reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: an enone + NADPH + H+ = a ketone + NADP+." [GOC:kad, PMID:17945329, PMID:19166903]
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
created_by: rfoulger
creation_date: 2011-02-04T10:59:15Z

[Term]
id: GO:0035672
name: oligopeptide transmembrane transport
namespace: biological_process
def: "The directed movement of an oligopeptide across a membrane by means of some agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [GOC:vw, ISBN:0198506732]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "oligopeptide membrane transport" EXACT []
is_a: GO:0006857 ! oligopeptide transport
is_a: GO:0055085 ! transmembrane transport
created_by: rfoulger
creation_date: 2011-02-08T02:18:07Z

[Term]
id: GO:0035673
name: oligopeptide transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of oligopeptides from one side of the membrane to the other." [GOC:vw]
is_a: GO:0015198 ! oligopeptide transporter activity
is_a: GO:1904680 ! peptide transmembrane transporter activity
relationship: part_of GO:0035672 ! oligopeptide transmembrane transport
created_by: rfoulger
creation_date: 2011-02-08T02:20:14Z

[Term]
id: GO:0035674
name: tricarboxylic acid transmembrane transport
namespace: biological_process
def: "The process in which tricarboxylic acids are transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "tricarboxylic acid membrane transport" EXACT []
is_a: GO:0006842 ! tricarboxylic acid transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport
created_by: rfoulger
creation_date: 2011-02-08T02:37:31Z

[Term]
id: GO:0035675
name: neuromast hair cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a neuromast hair cell over time, from its formation to the mature structure. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. Cell development does not include the steps involved in committing a cell to a specific fate." [CL:0000856]
is_a: GO:0048935 ! peripheral nervous system neuron development
relationship: part_of GO:0048886 ! neuromast hair cell differentiation
created_by: rfoulger
creation_date: 2011-02-14T11:01:42Z

[Term]
id: GO:0035676
name: anterior lateral line neuromast hair cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of an anterior lateral line neuromast hair cell over time, from its formation to the mature structure. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. Cell development does not include the steps involved in committing a cell to a specific fate." [ISBN:0125296509, ISBN:0387968377]
is_a: GO:0035675 ! neuromast hair cell development
relationship: part_of GO:0048903 ! anterior lateral line neuromast hair cell differentiation
created_by: rfoulger
creation_date: 2011-02-14T11:03:57Z

[Term]
id: GO:0035677
name: posterior lateral line neuromast hair cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a posterior lateral line neuromast hair cell over time, from its formation to the mature structure. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. Cell development does not include the steps involved in committing a cell to a specific fate." [ISBN:0125296509]
is_a: GO:0035675 ! neuromast hair cell development
relationship: part_of GO:0048923 ! posterior lateral line neuromast hair cell differentiation
created_by: rfoulger
creation_date: 2011-02-14T11:04:57Z

[Term]
id: GO:0035678
name: neuromast hair cell morphogenesis
namespace: biological_process
def: "The change in form (cell shape and size) that occurs when a neuromast hair cell progresses from its initial formation to its mature state. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface." [CL:0000856]
is_a: GO:0048667 ! cell morphogenesis involved in neuron differentiation
relationship: part_of GO:0035675 ! neuromast hair cell development
created_by: rfoulger
creation_date: 2011-02-14T11:06:15Z

[Term]
id: GO:0035679
name: anterior lateral line neuromast hair cell morphogenesis
namespace: biological_process
def: "The change in form (cell shape and size) that occurs when an anterior lateral line neuromast hair cell progresses from its initial formation to its mature state. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface." [ISBN:0125296509, ISBN:0387968377]
is_a: GO:0035678 ! neuromast hair cell morphogenesis
relationship: part_of GO:0035676 ! anterior lateral line neuromast hair cell development
created_by: rfoulger
creation_date: 2011-02-14T11:06:54Z

[Term]
id: GO:0035680
name: posterior lateral line neuromast hair cell morphogenesis
namespace: biological_process
def: "The change in form (cell shape and size) that occurs when a posterior lateral line neuromast hair cell progresses from its initial formation to its mature state. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface." [ISBN:0125296509]
is_a: GO:0035678 ! neuromast hair cell morphogenesis
relationship: part_of GO:0035677 ! posterior lateral line neuromast hair cell development
created_by: rfoulger
creation_date: 2011-02-14T11:08:14Z

[Term]
id: GO:0035681
name: toll-like receptor 15 signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 15." [GOC:pde]
synonym: "TLR15 signaling pathway" EXACT [GOC:bf]
synonym: "toll-like receptor 15 signalling pathway" EXACT [GOC:mah]
xref: Reactome:REACT_27188 "TLR15 cascade, Gallus gallus"
is_a: GO:0002224 ! toll-like receptor signaling pathway
created_by: rfoulger
creation_date: 2011-02-21T02:38:47Z

[Term]
id: GO:0035682
name: toll-like receptor 21 signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 21." [GOC:pde]
synonym: "TLR21 signaling pathway" EXACT [GOC:bf]
synonym: "toll-like receptor 21 signalling pathway" EXACT [GOC:mah]
xref: Reactome:REACT_27302 "TLR21 cascade, Gallus gallus"
is_a: GO:0002224 ! toll-like receptor signaling pathway
created_by: rfoulger
creation_date: 2011-02-21T02:39:39Z

[Term]
id: GO:0035683
name: memory T cell extravasation
namespace: biological_process
def: "The migration of a memory T cell from the blood vessels into the surrounding tissue. A memory T cell is a distinctly differentiated long-lived T cell that has the phenotype CD45RO-positive and CD127-positive." [CL:0000813, GOC:BHF]
synonym: "memory T-cell extravasation" EXACT [GOC:ebc]
is_a: GO:0072683 ! T cell extravasation
created_by: rfoulger
creation_date: 2011-02-23T01:10:02Z

[Term]
id: GO:0035684
name: helper T cell extravasation
namespace: biological_process
def: "The migration of a helper T cell from the blood vessels into the surrounding tissue. A helper T-cell is an effector T cell that provides help in the form of secreted cytokines to other immune cells." [CL:0000912, GOC:BHF]
synonym: "helper T-cell extravasation" EXACT [GOC:ebc]
synonym: "T-helper cell extravasation" EXACT [CL:0000912]
is_a: GO:0072683 ! T cell extravasation
created_by: rfoulger
creation_date: 2011-02-23T01:11:05Z

[Term]
id: GO:0035685
name: helper T cell diapedesis
namespace: biological_process
def: "The passage of a helper T cell between the tight junctions of endothelial cells lining blood vessels, typically the fourth and final step of cellular extravasation." [CL:0000912, GOC:BHF]
synonym: "helper T-cell diapedesis" EXACT [CL:0000912]
synonym: "T-helper cell diapedesis" EXACT [CL:0000912]
is_a: GO:0050904 ! diapedesis
is_a: GO:0072678 ! T cell migration
relationship: part_of GO:0035684 ! helper T cell extravasation
created_by: rfoulger
creation_date: 2011-02-23T01:11:52Z

[Term]
id: GO:0035686
name: sperm fibrous sheath
namespace: cellular_component
def: "A cytoskeletal structure surrounding the axoneme and outer dense fibers of the sperm flagellum. Consists of two longitudinal columns connected by closely arrayed semicircular ribs that assemble from distal to proximal throughout spermiogenesis. The fibrous sheath probably influences the degree of flexibility, plane of flagellar motion, and the shape of the flagellar beat." [GOC:BHF, GOC:cilia, GOC:krc, PMID:20731842, PMID:3282552]
synonym: "flagellar fibrous sheath" EXACT []
synonym: "flagellum fibrous sheath" EXACT [GOC:bf]
is_a: GO:0044441 ! ciliary part
is_a: GO:0097223 ! sperm part
relationship: part_of GO:0036126 ! sperm flagellum
created_by: rfoulger
creation_date: 2011-02-24T09:10:58Z

[Term]
id: GO:0035687
name: T-helper 1 cell extravasation
namespace: biological_process
def: "The migration of a T-helper 1 cell from the blood vessels into the surrounding tissue. A T-helper 1 cell is a CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma." [CL:0000545, GOC:BHF]
synonym: "Th1 cell extravasation" EXACT [CL:0000545]
is_a: GO:0035684 ! helper T cell extravasation
is_a: GO:0035697 ! CD8-positive, alpha-beta T cell extravasation
created_by: rfoulger
creation_date: 2011-02-24T10:10:00Z

[Term]
id: GO:0035688
name: T-helper 1 cell diapedesis
namespace: biological_process
def: "The passage of a T-helper 1 cell between the tight junctions of endothelial cells lining blood vessels, typically the fourth and final step of cellular extravasation. A T-helper 1 cell is a CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma." [CL:0000545, GOC:BHF, PMID:10477596]
synonym: "Th1 cell diapedesis" EXACT [CL:0000545]
is_a: GO:0035685 ! helper T cell diapedesis
relationship: part_of GO:0035687 ! T-helper 1 cell extravasation
created_by: rfoulger
creation_date: 2011-02-24T10:12:11Z

[Term]
id: GO:0035689
name: chemokine (C-C motif) ligand 5 signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of the chemokine CCL5 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, PMID:18337562]
synonym: "CCL5-mediated signaling pathway" EXACT [PMID:18337562]
synonym: "chemokine (C-C motif) ligand 5 signalling pathway" EXACT [GOC:mah]
synonym: "RANTES-mediated signaling pathway" EXACT [PMID:19122644]
is_a: GO:0070098 ! chemokine-mediated signaling pathway
created_by: rfoulger
creation_date: 2011-02-24T12:56:13Z

[Term]
id: GO:0035690
name: cellular response to drug
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease." [GOC:sl]
subset: goslim_chembl
is_a: GO:0042493 ! response to drug
is_a: GO:0070887 ! cellular response to chemical stimulus
created_by: rfoulger
creation_date: 2011-02-24T03:37:26Z

[Term]
id: GO:0035691
name: macrophage migration inhibitory factor signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of macrophage migration inhibitory factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:signaling, PMID:12782713, PMID:19413900]
synonym: "macrophage migration inhibitory factor signalling pathway" EXACT [GOC:mah]
synonym: "MIF signaling pathway" EXACT [GOC:ebc]
is_a: GO:0019221 ! cytokine-mediated signaling pathway
created_by: rfoulger
creation_date: 2011-02-25T11:31:21Z

[Term]
id: GO:0035692
name: macrophage migration inhibitory factor receptor complex
namespace: cellular_component
def: "A protein complex that binds macrophage migration inhibitory factor. Comprises CD74 and CD44 cell surface proteins." [GOC:BHF, PMID:12782713, PMID:17045821]
is_a: GO:0043235 ! receptor complex
created_by: rfoulger
creation_date: 2011-02-25T11:33:15Z

[Term]
id: GO:0035693
name: NOS2-CD74 complex
namespace: cellular_component
def: "A protein complex comprising nitric oxide synthase 2 and CD74. This stable complex formation is thought to prevent CD74 degradation by caspases." [GOC:BHF, PMID:18003616]
is_a: GO:0043234 ! protein complex
created_by: rfoulger
creation_date: 2011-02-25T11:35:38Z

[Term]
id: GO:0035694
name: mitochondrial protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a mitochondrial protein. This process is necessary to maintain the healthy state of mitochondria and is thought to occur via the induction of an intramitochondrial lysosome-like organelle that acts to eliminate the damaged oxidised mitochondrial proteins without destroying the mitochondrial structure." [GOC:sp, PMID:21264221, PMID:21264228]
synonym: "catabolism of mitochondrial protein" EXACT [GOC:bf]
synonym: "degradation of damaged mitochondrial protein" EXACT [GOC:bf]
is_a: GO:0044257 ! cellular protein catabolic process
intersection_of: GO:0030163 ! protein catabolic process
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion
relationship: part_of GO:0007005 ! mitochondrion organization
created_by: rfoulger
creation_date: 2011-02-28T11:06:40Z

[Term]
id: GO:0035695
name: mitophagy by induced vacuole formation
namespace: biological_process
def: "The process in which cells degrade mitochondria by inducing a vacuole-like structure which directly engulfs and degrades the unhealthy mitochondria by accumulating lysosomes." [GOC:autophagy, GOC:bf, GOC:sp, PMID:21264228]
comment: In this mechanism of mitochondrion degradation, the mitochondrion is directly engulfed by a lysosome-like vacuole. It is therefore distinct from canonical autophagy, which is mediated by a double-membrane autophagosome.
synonym: "MIV-mediated mitophagy" NARROW [PMID:21264228]
is_a: GO:0000422 ! mitophagy
created_by: rfoulger
creation_date: 2011-02-28T03:01:04Z

[Term]
id: GO:0035696
name: monocyte extravasation
namespace: biological_process
def: "The migration of a monocyte from the blood vessels into the surrounding tissue." [CL:0000576, GOC:BHF, PMID:10657654]
is_a: GO:0045123 ! cellular extravasation
is_a: GO:0097529 ! myeloid leukocyte migration
created_by: rfoulger
creation_date: 2011-02-28T03:05:52Z

[Term]
id: GO:0035697
name: CD8-positive, alpha-beta T cell extravasation
namespace: biological_process
def: "The migration of a CD8-positive, alpha-beta T cell from the blood vessels into the surrounding tissue." [CL:0000625, GOC:BHF]
is_a: GO:0072683 ! T cell extravasation
created_by: rfoulger
creation_date: 2011-02-28T03:08:49Z

[Term]
id: GO:0035698
name: CD8-positive, alpha-beta cytotoxic T cell extravasation
namespace: biological_process
def: "The migration of a CD8-positive, alpha-beta cytotoxic T cell from the blood vessels into the surrounding tissue." [CL:0000794, GOC:BHF]
is_a: GO:0035697 ! CD8-positive, alpha-beta T cell extravasation
created_by: rfoulger
creation_date: 2011-02-28T03:09:53Z

[Term]
id: GO:0035699
name: T-helper 17 cell extravasation
namespace: biological_process
def: "The migration of a T-helper 17 cell from the blood vessels into the surrounding tissue." [CL:0000899, GOC:BHF]
is_a: GO:0035684 ! helper T cell extravasation
is_a: GO:0035697 ! CD8-positive, alpha-beta T cell extravasation
created_by: rfoulger
creation_date: 2011-02-28T03:13:27Z

[Term]
id: GO:0035700
name: astrocyte chemotaxis
namespace: biological_process
def: "The directed movement of an astrocyte guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [CL:0000127, GOC:BHF, PMID:12271471]
is_a: GO:0043615 ! astrocyte cell migration
is_a: GO:0060326 ! cell chemotaxis
created_by: rfoulger
creation_date: 2011-02-28T03:17:52Z

[Term]
id: GO:0035701
name: hematopoietic stem cell migration
namespace: biological_process
def: "The orderly movement of a hematopoietic stem cell from one site to another. A hematopoietic stem cell is a cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system." [CL:0000037, GOC:BHF, PMID:20234092]
synonym: "hemopoietic stem cell migration" EXACT [CL:0000037]
is_a: GO:0016477 ! cell migration
created_by: rfoulger
creation_date: 2011-02-28T03:20:36Z

[Term]
id: GO:0035702
name: monocyte homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of monocytes such that the total number of monocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus." [CL:0000576, GOC:BHF, PMID:18832716]
is_a: GO:0001776 ! leukocyte homeostasis
is_a: GO:0002262 ! myeloid cell homeostasis
created_by: rfoulger
creation_date: 2011-03-02T11:32:57Z

[Term]
id: GO:0035703
name: monocyte migration into blood stream
namespace: biological_process
def: "The movement of a monocyte from the bone marrow to the blood stream." [CL:0000576, GOC:BHF]
synonym: "release of monocytes into circulation" EXACT [GOC:bf]
is_a: GO:0097529 ! myeloid leukocyte migration
relationship: part_of GO:0008015 ! blood circulation
created_by: rfoulger
creation_date: 2011-03-02T11:37:54Z

[Term]
id: GO:0035704
name: helper T cell chemotaxis
namespace: biological_process
def: "The directed movement of a helper T cell in response to an external stimulus." [CL:0000912, GOC:BHF]
synonym: "T-helper cell chemotaxis" EXACT [CL:0000912]
is_a: GO:0010818 ! T cell chemotaxis
created_by: rfoulger
creation_date: 2011-03-02T02:31:48Z

[Term]
id: GO:0035705
name: T-helper 17 cell chemotaxis
namespace: biological_process
def: "The directed movement of a T-helper 17 cell in response to an external stimulus." [CL:0000899, GOC:BHF]
synonym: "Th17 cell chemotaxis" EXACT [CL:0000899]
is_a: GO:0035704 ! helper T cell chemotaxis
created_by: rfoulger
creation_date: 2011-03-02T02:35:16Z

[Term]
id: GO:0035706
name: T-helper 1 cell chemotaxis
namespace: biological_process
def: "The directed movement of a T-helper 1 cell in response to an external stimulus." [CL:0000545, GOC:BHF]
synonym: "Th1 cell chemotaxis" EXACT [CL:0000545]
is_a: GO:0035704 ! helper T cell chemotaxis
created_by: rfoulger
creation_date: 2011-03-02T02:36:49Z

[Term]
id: GO:0035707
name: T-helper 2 cell chemotaxis
namespace: biological_process
def: "The directed movement of a T-helper 2 cell in response to an external stimulus." [CL:0000546, GOC:BHF]
synonym: "Th2 cell chemotaxis" EXACT [CL:0000546]
is_a: GO:0035704 ! helper T cell chemotaxis
created_by: rfoulger
creation_date: 2011-03-02T02:37:44Z

[Term]
id: GO:0035708
name: interleukin-4-dependent isotype switching to IgE isotypes
namespace: biological_process
def: "The switching of activated B cells from IgM biosynthesis to IgE biosynthesis, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and IgE constant region gene segments in the immunoglobulin heavy chain locus, that is dependent on the activity of interleukin 4 (IL-4)." [GOC:BHF, PMID:12496423]
synonym: "IL-4-dependent isotype switching to IgE isotypes" EXACT [GOC:add, GOC:bf]
is_a: GO:0048289 ! isotype switching to IgE isotypes
created_by: rfoulger
creation_date: 2011-03-02T02:40:35Z

[Term]
id: GO:0035709
name: memory T cell activation
namespace: biological_process
def: "The change in morphology and behavior of a memory T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [CL:0000813, GOC:BHF]
is_a: GO:0042110 ! T cell activation
created_by: rfoulger
creation_date: 2011-03-02T03:03:02Z

[Term]
id: GO:0035710
name: CD4-positive, alpha-beta T cell activation
namespace: biological_process
def: "The change in morphology and behavior of a CD4-positive, alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [CL:0000624, GOC:BHF]
is_a: GO:0046631 ! alpha-beta T cell activation
created_by: rfoulger
creation_date: 2011-03-02T03:04:11Z

[Term]
id: GO:0035711
name: T-helper 1 cell activation
namespace: biological_process
def: "The change in morphology and behavior of a T-helper 1 cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [CL:0000545, GOC:BHF]
synonym: "Th1 cell activation" EXACT [CL:0000545]
is_a: GO:0035710 ! CD4-positive, alpha-beta T cell activation
created_by: rfoulger
creation_date: 2011-03-02T03:05:08Z

[Term]
id: GO:0035712
name: T-helper 2 cell activation
namespace: biological_process
def: "The change in morphology and behavior of a T helper 2 cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [CL:0000546, GOC:BHF]
synonym: "Th2 cell activation" EXACT [CL:0000546]
is_a: GO:0035710 ! CD4-positive, alpha-beta T cell activation
created_by: rfoulger
creation_date: 2011-03-02T03:05:59Z

[Term]
id: GO:0035713
name: response to nitrogen dioxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen dioxide (NO2) stimulus." [CHEBI:33101, GOC:BHF]
synonym: "response to NO2" EXACT [CHEBI:33101]
is_a: GO:0010035 ! response to inorganic substance
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: rfoulger
creation_date: 2011-03-02T03:14:51Z

[Term]
id: GO:0035714
name: cellular response to nitrogen dioxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen dioxide (NO2) stimulus." [CHEBI:33101, GOC:BHF]
synonym: "cellular response to NO2" EXACT [CHEBI:33101]
is_a: GO:0035713 ! response to nitrogen dioxide
is_a: GO:0071241 ! cellular response to inorganic substance
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: rfoulger
creation_date: 2011-03-02T03:16:37Z

[Term]
id: GO:0035715
name: chemokine (C-C motif) ligand 2 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with chemokine (C-C motif) ligand 2." [GOC:BHF]
synonym: "CCL2 binding" EXACT [GOC:ebc]
is_a: GO:0019957 ! C-C chemokine binding
created_by: rfoulger
creation_date: 2011-03-03T04:24:24Z

[Term]
id: GO:0035716
name: chemokine (C-C motif) ligand 12 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with chemokine (C-C motif) ligand 12." [GOC:BHF]
synonym: "CCL12 binding" EXACT [GOC:ebc]
is_a: GO:0019957 ! C-C chemokine binding
created_by: rfoulger
creation_date: 2011-03-03T04:25:01Z

[Term]
id: GO:0035717
name: chemokine (C-C motif) ligand 7 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with chemokine (C-C motif) ligand 7." [GOC:BHF]
synonym: "CCL7 binding" EXACT [GOC:ebc]
is_a: GO:0019957 ! C-C chemokine binding
created_by: rfoulger
creation_date: 2011-03-03T04:25:41Z

[Term]
id: GO:0035718
name: macrophage migration inhibitory factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the cytokine, macrophage migration inhibitory factor." [GOC:BHF, PMID:19601712]
synonym: "MIF binding" EXACT [PMID:19601712]
is_a: GO:0019955 ! cytokine binding
created_by: rfoulger
creation_date: 2011-03-03T04:27:16Z

[Term]
id: GO:0035719
name: tRNA import into nucleus
namespace: biological_process
def: "The directed movement of tRNA from the cytoplasm to the nucleus." [GOC:vw, PMID:20032305]
synonym: "retrograde tRNA transport into nucleus" EXACT [GOC:vw, PMID:20032305]
synonym: "tRNA nuclear import" EXACT [GOC:vw]
is_a: GO:0006404 ! RNA import into nucleus
is_a: GO:0051031 ! tRNA transport
is_a: GO:1902593 ! single-organism nuclear import
created_by: rfoulger
creation_date: 2011-03-03T04:32:35Z

[Term]
id: GO:0035720
name: intraciliary anterograde transport
namespace: biological_process
def: "The directed movement of large protein complexes along microtubules from the cell body toward the tip of a cilium (also called flagellum), mediated by motor proteins." [GOC:BHF, GOC:cilia, PMID:17895364]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.
synonym: "intraflagellar anterograde transport" EXACT []
is_a: GO:0042073 ! intraciliary transport
created_by: rfoulger
creation_date: 2011-03-07T11:24:53Z

[Term]
id: GO:0035721
name: intraciliary retrograde transport
namespace: biological_process
def: "The directed movement of large protein complexes along microtubules from the tip of a cilium (also called flagellum) toward the cell body, mediated by motor proteins." [GOC:BHF, GOC:cilia]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.
synonym: "intraflagellar retrograde transport" EXACT []
is_a: GO:0042073 ! intraciliary transport
created_by: rfoulger
creation_date: 2011-03-07T11:25:32Z

[Term]
id: GO:0035722
name: interleukin-12-mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of interleukin-12 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:signaling]
synonym: "IL-12-mediated signaling pathway" EXACT [GOC:bf]
synonym: "interleukin-12-mediated signalling pathway" EXACT [GOC:bf]
is_a: GO:0019221 ! cytokine-mediated signaling pathway
relationship: part_of GO:0071349 ! cellular response to interleukin-12
created_by: rfoulger
creation_date: 2011-03-07T11:27:58Z

[Term]
id: GO:0035723
name: interleukin-15-mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of interleukin-15 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:signaling]
synonym: "IL-15-mediated signaling pathway" EXACT [GOC:bf]
synonym: "interleukin-15-mediated signalling pathway" EXACT [GOC:bf]
is_a: GO:0019221 ! cytokine-mediated signaling pathway
relationship: part_of GO:0071350 ! cellular response to interleukin-15
created_by: rfoulger
creation_date: 2011-03-07T11:28:29Z

[Term]
id: GO:0035724
name: CD24 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of CD24, a CD marker and cell adhesion molecule that occurs on many B-lineage cells and mature granulocytes, and is involved in B cell activation and differentiation as well as T cell co-stimulation." [GOC:BHF]
synonym: "CD24 anabolism" EXACT [GOC:bf]
synonym: "CD24 biosynthesis" EXACT [GOC:bf]
synonym: "CD24 formation" EXACT [GOC:bf]
synonym: "CD24 synthesis" EXACT [GOC:bf]
is_a: GO:0009101 ! glycoprotein biosynthetic process
created_by: rfoulger
creation_date: 2011-03-07T11:32:54Z

[Term]
id: GO:0035725
name: sodium ion transmembrane transport
namespace: biological_process
def: "A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "sodium ion membrane transport" EXACT []
is_a: GO:0006814 ! sodium ion transport
is_a: GO:0098662 ! inorganic cation transmembrane transport
created_by: rfoulger
creation_date: 2011-03-10T02:52:36Z

[Term]
id: GO:0035726
name: common myeloid progenitor cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of common myeloid progenitor cells, resulting in the expansion of a cell population. A common myeloid progenitor cell is a progenitor cell committed to the myeloid lineage." [CL:0000049, GOC:BHF]
is_a: GO:0008283 ! cell proliferation
created_by: rfoulger
creation_date: 2011-03-10T02:57:19Z

[Term]
id: GO:0035727
name: lysophosphatidic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with lysophosphatidic acid (LPA), a phospholipid derivative that acts as a potent mitogen due to its activation of high-affinity G-protein-coupled receptors." [CHEBI:52288]
synonym: "LPA binding" EXACT [CHEBI:52288]
is_a: GO:0005543 ! phospholipid binding
is_a: GO:0036041 ! long-chain fatty acid binding
is_a: GO:0097367 ! carbohydrate derivative binding
created_by: rfoulger
creation_date: 2011-03-10T03:00:05Z

[Term]
id: GO:0035728
name: response to hepatocyte growth factor
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hepatocyte growth factor stimulus." [GOC:bf]
synonym: "response to hepatocyte growth factor stimulus" EXACT [GOC:dos]
synonym: "response to HGF stimulus" EXACT [GOC:bf]
is_a: GO:0070848 ! response to growth factor
created_by: rfoulger
creation_date: 2011-03-10T03:02:47Z

[Term]
id: GO:0035729
name: cellular response to hepatocyte growth factor stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hepatocyte growth factor stimulus." [GOC:bf]
synonym: "cellular response to HGF stimulus" EXACT [GOC:bf]
is_a: GO:0035728 ! response to hepatocyte growth factor
is_a: GO:0071363 ! cellular response to growth factor stimulus
created_by: rfoulger
creation_date: 2011-03-10T03:04:19Z

[Term]
id: GO:0035730
name: S-nitrosoglutathione binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with S-nitrosoglutathione, a nitrosothiol considered to be a natural nitric oxide (NO) donor involved in S-nitrosylation, and in the storage and transport of nitric oxide in biological systems." [CHEBI:50091, GOC:BHF]
synonym: "GSNO binding" EXACT [CHEBI:50091]
is_a: GO:1901681 ! sulfur compound binding
created_by: rfoulger
creation_date: 2011-03-11T09:57:19Z

[Term]
id: GO:0035731
name: dinitrosyl-iron complex binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a dinitrosyl-iron complex. Nitric oxide (NO) is stored as dinitrosyl-iron complexes, which form spontaneously from Glutathione (GSH), S-nitrosoglutathione, and trace amounts of ferrous ions, or by reaction of iron-sulfur centers with NO." [GOC:BHF, PMID:10534443]
synonym: "dinitrosyl-diglutathionyl-iron complex binding" EXACT [PMID:12871931]
synonym: "DNDGIC binding" EXACT [PMID:12871931]
synonym: "DNIC binding" EXACT [PMID:10534443]
is_a: GO:0005488 ! binding
created_by: rfoulger
creation_date: 2011-03-11T09:58:31Z

[Term]
id: GO:0035732
name: nitric oxide storage
namespace: biological_process
def: "The accumulation and maintenance in cells or tissues of nitric oxide (NO). Nitric oxide is stored in the form of dinitrosyl-iron complexes, which are stabilized, and possibly sequestered, by binding to glutathione S-transferase proteins." [GOC:BHF, PMID:12871945]
synonym: "NO storage" EXACT [GOC:bf]
is_a: GO:0051179 ! localization
relationship: part_of GO:0033484 ! nitric oxide homeostasis
created_by: rfoulger
creation_date: 2011-03-11T10:00:31Z

[Term]
id: GO:0035733
name: hepatic stellate cell activation
namespace: biological_process
def: "A change in the morphology or behavior of a hepatic stellate cell resulting from exposure to a cytokine, chemokine, hormone, cellular ligand or soluble factor." [CL:0000632, GOC:bf]
is_a: GO:0072537 ! fibroblast activation
created_by: rfoulger
creation_date: 2011-03-11T10:04:12Z

[Term]
id: GO:0035735
name: intraciliary transport involved in cilium morphogenesis
namespace: biological_process
def: "The bidirectional movement of large protein complexes along microtubules within a cilium that contributes to cilium morphogenesis." [GOC:bf, GOC:cilia]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.
synonym: "intraflagellar transport involved in cilium morphogenesis" EXACT []
is_a: GO:0042073 ! intraciliary transport
intersection_of: GO:0042073 ! intraciliary transport
intersection_of: part_of GO:0060271 ! cilium morphogenesis
relationship: part_of GO:0060271 ! cilium morphogenesis
created_by: rfoulger
creation_date: 2011-03-17T10:55:42Z

[Term]
id: GO:0035736
name: cell proliferation involved in compound eye morphogenesis
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to compound eye morphogenesis." [GOC:bf, GOC:sart]
is_a: GO:0008283 ! cell proliferation
intersection_of: GO:0008283 ! cell proliferation
intersection_of: part_of GO:0001745 ! compound eye morphogenesis
relationship: part_of GO:0001745 ! compound eye morphogenesis
created_by: rfoulger
creation_date: 2011-03-17T10:57:03Z

[Term]
id: GO:0035737
name: injection of substance in to other organism
namespace: biological_process
def: "The process of forcing a substance into another organism, either by penetrating the skin of the other organism or by applying the substance externally to a sensitive tissue such as those that surround the eyes." [GOC:pamgo_curators]
is_a: GO:0051705 ! multi-organism behavior
created_by: rfoulger
creation_date: 2011-03-17T10:58:57Z

[Term]
id: GO:0035738
name: envenomation resulting in modification of morphology or physiology of other organism
namespace: biological_process
def: "The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with the manifestation of some change or damage to the bitten organism." [GOC:pamgo_curators]
is_a: GO:0035737 ! injection of substance in to other organism
intersection_of: GO:0035737 ! injection of substance in to other organism
intersection_of: has_part GO:0035821 ! modification of morphology or physiology of other organism
relationship: has_part GO:0035821 ! modification of morphology or physiology of other organism
created_by: rfoulger
creation_date: 2011-03-17T10:59:27Z

[Term]
id: GO:0035739
name: CD4-positive, alpha-beta T cell proliferation
namespace: biological_process
def: "The expansion of a CD4-positive, alpha-beta T cell population by cell division." [CL:0000624, GOC:BHF]
is_a: GO:0035710 ! CD4-positive, alpha-beta T cell activation
is_a: GO:0046633 ! alpha-beta T cell proliferation
created_by: rfoulger
creation_date: 2011-03-17T02:12:48Z

[Term]
id: GO:0035740
name: CD8-positive, alpha-beta T cell proliferation
namespace: biological_process
def: "The expansion of a CD8-positive, alpha-beta T cell population by cell division." [CL:0000625, GOC:BHF]
is_a: GO:0036037 ! CD8-positive, alpha-beta T cell activation
is_a: GO:0046633 ! alpha-beta T cell proliferation
created_by: rfoulger
creation_date: 2011-03-17T02:13:54Z

[Term]
id: GO:0035741
name: activated CD4-positive, alpha-beta T cell proliferation
namespace: biological_process
def: "The expansion of an activated CD4-positive, alpha-beta T cell population by cell division." [CL:0000896, GOC:BHF]
is_a: GO:0035739 ! CD4-positive, alpha-beta T cell proliferation
created_by: rfoulger
creation_date: 2011-03-17T02:18:39Z

[Term]
id: GO:0035742
name: activated CD8-positive, alpha-beta T cell proliferation
namespace: biological_process
def: "The expansion of an activated CD8-positive, alpha-beta T cell population by cell division." [CL:0000906, GOC:BHF]
is_a: GO:0035740 ! CD8-positive, alpha-beta T cell proliferation
created_by: rfoulger
creation_date: 2011-03-17T02:19:58Z

[Term]
id: GO:0035743
name: CD4-positive, alpha-beta T cell cytokine production
namespace: biological_process
def: "Any process that contributes to cytokine production by a CD4-positive, alpha-beta T cell." [CL:0000624, GOC:BHF]
is_a: GO:0002369 ! T cell cytokine production
created_by: rfoulger
creation_date: 2011-03-17T02:21:51Z

[Term]
id: GO:0035744
name: T-helper 1 cell cytokine production
namespace: biological_process
def: "Any process that contributes to cytokine production by a T-helper 1 cell." [CL:0000545, GOC:BHF]
synonym: "Th1 cell cytokine production" EXACT [CL:0000545]
is_a: GO:0035743 ! CD4-positive, alpha-beta T cell cytokine production
relationship: part_of GO:0042088 ! T-helper 1 type immune response
created_by: rfoulger
creation_date: 2011-03-17T02:22:54Z

[Term]
id: GO:0035745
name: T-helper 2 cell cytokine production
namespace: biological_process
def: "Any process that contributes to cytokine production by a T-helper 2 cell." [CL:0000546, GOC:BHF]
synonym: "Th2 cell cytokine production" EXACT [CL:0000546]
is_a: GO:0035743 ! CD4-positive, alpha-beta T cell cytokine production
relationship: part_of GO:0042092 ! type 2 immune response
created_by: rfoulger
creation_date: 2011-03-17T02:23:32Z

[Term]
id: GO:0035746
name: granzyme A production
namespace: biological_process
def: "The appearance of granzyme A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF]
is_a: GO:0002440 ! production of molecular mediator of immune response
created_by: rfoulger
creation_date: 2011-03-17T02:39:11Z

[Term]
id: GO:0035747
name: natural killer cell chemotaxis
namespace: biological_process
def: "The directed movement of a natural killer cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [CL:0000623, GOC:BHF]
is_a: GO:0048247 ! lymphocyte chemotaxis
created_by: rfoulger
creation_date: 2011-03-17T02:40:10Z

[Term]
id: GO:0035748
name: myelin sheath abaxonal region
namespace: cellular_component
def: "The region of the myelin sheath furthest from the axon." [GOC:BHF, PMID:20237282]
is_a: GO:0044464 ! cell part
relationship: part_of GO:0043209 ! myelin sheath
created_by: rfoulger
creation_date: 2011-03-23T10:16:14Z

[Term]
id: GO:0035749
name: myelin sheath adaxonal region
namespace: cellular_component
def: "The region of the myelin sheath nearest to the axon." [GOC:BHF, PMID:20237282]
is_a: GO:0044464 ! cell part
relationship: part_of GO:0043209 ! myelin sheath
created_by: rfoulger
creation_date: 2011-03-23T10:17:42Z

[Term]
id: GO:0035750
name: protein localization to myelin sheath abaxonal region
namespace: biological_process
def: "Any process in which a protein is transported to, and/or maintained in, the abaxonal region of the myelin sheath. The abaxonal region is the region of the myelin sheath furthest from the axon." [GOC:BHF, PMID:20237282]
synonym: "protein localisation to myelin sheath abaxonal region" EXACT [GOC:mah]
is_a: GO:0008105 ! asymmetric protein localization
is_a: GO:0034613 ! cellular protein localization
created_by: rfoulger
creation_date: 2011-03-23T10:20:06Z

[Term]
id: GO:0035751
name: regulation of lysosomal lumen pH
namespace: biological_process
def: "Any process that modulates the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion." [GOC:rph]
is_a: GO:0051453 ! regulation of intracellular pH
relationship: part_of GO:0007040 ! lysosome organization
created_by: rfoulger
creation_date: 2011-03-23T10:23:41Z

[Term]
id: GO:0035752
name: lysosomal lumen pH elevation
namespace: biological_process
def: "Any process that increases the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion." [GOC:bf, GOC:rph]
synonym: "lysosome pH elevation" EXACT [GOC:bf, GOC:rph]
is_a: GO:0035751 ! regulation of lysosomal lumen pH
is_a: GO:0051454 ! intracellular pH elevation
created_by: rfoulger
creation_date: 2011-03-23T10:24:24Z

[Term]
id: GO:0035753
name: maintenance of DNA trinucleotide repeats
namespace: biological_process
def: "Any process involved in sustaining the fidelity and copy number of DNA trinucleotide repeats. DNA trinucleotide repeats are naturally occurring runs of three base-pairs." [GOC:rb, PMID:21347277, SO:0000291]
is_a: GO:0043570 ! maintenance of DNA repeat elements
created_by: rfoulger
creation_date: 2011-03-23T10:29:02Z

[Term]
id: GO:0035754
name: B cell chemotaxis
namespace: biological_process
def: "The directed movement of a B cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [CL:0000236, GOC:BHF]
is_a: GO:0048247 ! lymphocyte chemotaxis
created_by: rfoulger
creation_date: 2011-03-23T10:30:33Z

[Term]
id: GO:0035755
name: cardiolipin hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of cardiolipin (1,3-bis(3-phosphatidyl)glycerol) to form phosphatidic acid (PA)." [CHEBI:28494, GOC:sp, PMID:17028579, PMID:21397848]
is_a: GO:0004620 ! phospholipase activity
is_a: GO:0008081 ! phosphoric diester hydrolase activity
created_by: rfoulger
creation_date: 2011-03-24T10:14:05Z

[Term]
id: GO:0035756
name: transepithelial migration of symbiont in host
namespace: biological_process
def: "The directional movement of an organism from one side of an epithelium to the other within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:bf, PMID:10639460]
synonym: "migration in host through an epithelial cell layer" EXACT [GOC:bf]
synonym: "migration of symbiont within host by transepithelial trafficking" EXACT [GOC:bf]
is_a: GO:0044001 ! migration in host
created_by: rfoulger
creation_date: 2011-03-24T10:20:03Z

[Term]
id: GO:0035757
name: chemokine (C-C motif) ligand 19 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with chemokine (C-C motif) ligand 19." [GOC:BHF]
synonym: "CCL19 binding" EXACT [GOC:bf]
is_a: GO:0019957 ! C-C chemokine binding
created_by: rfoulger
creation_date: 2011-03-25T02:02:36Z

[Term]
id: GO:0035758
name: chemokine (C-C motif) ligand 21 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with chemokine (C-C motif) ligand 21." [GOC:BHF]
synonym: "CCL21 binding" EXACT [GOC:bf]
is_a: GO:0019957 ! C-C chemokine binding
created_by: rfoulger
creation_date: 2011-03-25T02:03:53Z

[Term]
id: GO:0035759
name: mesangial cell-matrix adhesion
namespace: biological_process
def: "The binding of a mesangial cell to the extracellular matrix via adhesion molecules. A mesangial cell is a cell that encapsulates the capillaries and venules in the kidney." [CL:0000650, GOC:BHF, PMID:15569314]
is_a: GO:0007160 ! cell-matrix adhesion
created_by: rfoulger
creation_date: 2011-03-25T02:06:21Z

[Term]
id: GO:0035760
name: cytoplasmic polyadenylation-dependent rRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways occurring in the cytoplasm and resulting in the breakdown of a ribosomal RNA (rRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target rRNA truncated degradation intermediate." [PMID:20368444]
synonym: "cytoplasmic poly(A)-dependent rRNA catabolic process" RELATED [GOC:vw]
is_a: GO:0016075 ! rRNA catabolic process
is_a: GO:0043634 ! polyadenylation-dependent ncRNA catabolic process
created_by: rfoulger
creation_date: 2011-03-25T02:14:50Z

[Term]
id: GO:0035761
name: dorsal motor nucleus of vagus nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the dorsal motor nucleus of the vagus nerve to attain its fully functional state." [GOC:dgh]
is_a: GO:0071695 ! anatomical structure maturation
relationship: part_of GO:0021744 ! dorsal motor nucleus of vagus nerve development
created_by: rfoulger
creation_date: 2011-03-29T02:45:50Z

[Term]
id: GO:0035762
name: dorsal motor nucleus of vagus nerve morphogenesis
namespace: biological_process
def: "The process in which the dorsal motor nucleus of the vagus nerve is generated and organized. Morphogenesis pertains to the creation of form." [GOC:dgh]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0021744 ! dorsal motor nucleus of vagus nerve development
created_by: rfoulger
creation_date: 2011-03-29T02:47:18Z

[Term]
id: GO:0035763
name: dorsal motor nucleus of vagus nerve structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the dorsal motor nucleus of the vagus nerve. This process pertains to the physical shaping of a rudimentary structure." [GOC:dgh]
synonym: "dorsal motor nucleus of vagus nerve structural organisation" EXACT [GOC:mah]
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0035762 ! dorsal motor nucleus of vagus nerve morphogenesis
created_by: rfoulger
creation_date: 2011-03-29T02:47:56Z

[Term]
id: GO:0035764
name: dorsal motor nucleus of vagus nerve formation
namespace: biological_process
def: "The process that gives rise to the dorsal motor nucleus of the vagus nerve. This process pertains to the initial formation of a structure from unspecified parts." [GOC:dgh]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0035762 ! dorsal motor nucleus of vagus nerve morphogenesis
created_by: rfoulger
creation_date: 2011-03-29T02:48:26Z

[Term]
id: GO:0035765
name: motor neuron precursor migration involved in dorsal motor nucleus of vagus nerve formation
namespace: biological_process
def: "The orderly movement of a motor neuron precursor cell that contributes to formation of the dorsal motor nucleus of the vagus nerve." [GOC:dgh, PMID:21262462]
is_a: GO:0021535 ! cell migration in hindbrain
intersection_of: GO:0021535 ! cell migration in hindbrain
intersection_of: part_of GO:0035764 ! dorsal motor nucleus of vagus nerve formation
relationship: part_of GO:0035764 ! dorsal motor nucleus of vagus nerve formation
created_by: rfoulger
creation_date: 2011-03-29T02:52:09Z

[Term]
id: GO:0035766
name: cell chemotaxis to fibroblast growth factor
namespace: biological_process
def: "The directed movement of a motile cell in response to the presence of fibroblast growth factor (FGF)." [GOC:BHF]
is_a: GO:0060326 ! cell chemotaxis
relationship: part_of GO:0044344 ! cellular response to fibroblast growth factor stimulus
created_by: rfoulger
creation_date: 2011-03-31T04:30:16Z

[Term]
id: GO:0035767
name: endothelial cell chemotaxis
namespace: biological_process
def: "The directed movement of an endothelial cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [CL:0000115, GOC:BHF]
is_a: GO:0043542 ! endothelial cell migration
is_a: GO:0060326 ! cell chemotaxis
created_by: rfoulger
creation_date: 2011-03-31T04:31:37Z

[Term]
id: GO:0035768
name: endothelial cell chemotaxis to fibroblast growth factor
namespace: biological_process
def: "The directed movement of an endothelial cell in response to the presence of fibroblast growth factor (FGF)." [CL:0000115, GOC:BHF]
is_a: GO:0035766 ! cell chemotaxis to fibroblast growth factor
is_a: GO:0035767 ! endothelial cell chemotaxis
created_by: rfoulger
creation_date: 2011-03-31T04:32:17Z

[Term]
id: GO:0035769
name: B cell chemotaxis across high endothelial venule
namespace: biological_process
def: "The movement of a B cell to cross a high endothelial venule in response to an external stimulus." [CL:0000236, GOC:BHF]
synonym: "B-cell chemotaxis across high endothelial venule" EXACT [GOC:ebc]
is_a: GO:0002518 ! lymphocyte chemotaxis across high endothelial venule
is_a: GO:0035754 ! B cell chemotaxis
created_by: rfoulger
creation_date: 2011-04-01T10:48:59Z

[Term]
id: GO:0035770
name: ribonucleoprotein granule
namespace: cellular_component
def: "A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions." [GOC:go_curators, GOC:sp, PMID:16520386, PMID:20368989, PMID:21436445]
synonym: "mRNP granule" EXACT []
synonym: "RNA granule" NARROW []
synonym: "RNP granule" EXACT []
is_a: GO:0030529 ! intracellular ribonucleoprotein complex
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle
created_by: rfoulger
creation_date: 2011-04-01T10:50:47Z

[Term]
id: GO:0035771
name: interleukin-4-mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of interleukin-4 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:signaling]
synonym: "IL-4-mediated signaling pathway" EXACT [GOC:bf]
synonym: "interleukin-4-mediated signalling pathway" EXACT [GOC:bf]
is_a: GO:0019221 ! cytokine-mediated signaling pathway
relationship: part_of GO:0071353 ! cellular response to interleukin-4
created_by: rfoulger
creation_date: 2011-04-01T10:56:46Z

[Term]
id: GO:0035772
name: interleukin-13-mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of interleukin-13 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:signaling]
synonym: "IL-13-mediated signaling pathway" EXACT [GOC:bf]
synonym: "interleukin-13-mediated signalling pathway" EXACT [GOC:bf]
is_a: GO:0019221 ! cytokine-mediated signaling pathway
relationship: part_of GO:0035963 ! cellular response to interleukin-13
created_by: rfoulger
creation_date: 2011-04-01T11:00:11Z

[Term]
id: GO:0035773
name: insulin secretion involved in cellular response to glucose stimulus
namespace: biological_process
def: "The regulated release of proinsulin from secretory granules (B granules) in the B cells of the pancreas; accompanied by cleavage of proinsulin to form mature insulin, in response to a glucose stimulus." [GOC:bf, GOC:yaf, PMID:8492079]
synonym: "insulin secretion involved in cellular response to glucose" EXACT [GOC:bf]
is_a: GO:0030073 ! insulin secretion
is_a: GO:0051649 ! establishment of localization in cell
intersection_of: GO:0030073 ! insulin secretion
intersection_of: part_of GO:0071333 ! cellular response to glucose stimulus
relationship: part_of GO:0071333 ! cellular response to glucose stimulus
created_by: rfoulger
creation_date: 2011-04-01T01:14:40Z

[Term]
id: GO:0035774
name: positive regulation of insulin secretion involved in cellular response to glucose stimulus
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose." [GOC:bf, GOC:yaf]
synonym: "positive regulation of insulin secretion in response to glucose" EXACT [GOC:bf]
is_a: GO:0032024 ! positive regulation of insulin secretion
is_a: GO:0032846 ! positive regulation of homeostatic process
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:0061178 ! regulation of insulin secretion involved in cellular response to glucose stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035773 ! insulin secretion involved in cellular response to glucose stimulus
relationship: positively_regulates GO:0035773 ! insulin secretion involved in cellular response to glucose stimulus
created_by: rfoulger
creation_date: 2011-04-01T01:49:09Z

[Term]
id: GO:0035775
name: pronephric glomerulus morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the pronephric glomerulus are generated and organized. The pronephric glomerulus is part of the pronephric nephron and is restricted to one body segment." [GOC:mtg_kidney_jan10, GOC:yaf, PMID:18787069]
comment: This term is intended for annotation of fish and other organisms which contain a glomerulus as part of the pronephric nephron. It should not be used for annotation of Xenopus, which contains a pronephric glomus rather than a glomerulus.
is_a: GO:0072102 ! glomerulus morphogenesis
relationship: part_of GO:0039021 ! pronephric glomerulus development
created_by: rfoulger
creation_date: 2011-04-04T10:59:28Z

[Term]
id: GO:0035776
name: pronephric proximal tubule development
namespace: biological_process
def: "The progression of the pronephric proximal tubule over time, from its formation to the mature structure. A pronephric nephron tubule is an epithelial tube that is part of the pronephros." [GOC:mtg_kidney_jan10, GOC:yaf, PMID:18787069]
is_a: GO:0039020 ! pronephric nephron tubule development
is_a: GO:0072014 ! proximal tubule development
created_by: rfoulger
creation_date: 2011-04-04T11:02:54Z

[Term]
id: GO:0035777
name: pronephric distal tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pronephric distal tubule over time, from its formation to the mature structure. A pronephric nephron tubule is an epithelial tube that is part of the pronephros." [GOC:mtg_kidney_jan10, GOC:yaf, PMID:18787069]
is_a: GO:0039020 ! pronephric nephron tubule development
is_a: GO:0072017 ! distal tubule development
created_by: rfoulger
creation_date: 2011-04-04T11:06:01Z

[Term]
id: GO:0035778
name: pronephric nephron tubule epithelial cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the pronephric nephron tubule as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10, GOC:yaf, PMID:18787069]
is_a: GO:0039014 ! cell differentiation involved in pronephros development
is_a: GO:0072160 ! nephron tubule epithelial cell differentiation
relationship: part_of GO:0039020 ! pronephric nephron tubule development
created_by: rfoulger
creation_date: 2011-04-04T11:07:47Z

[Term]
id: GO:0035779
name: angioblast cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an angioblast cell. Angioblasts are one of the two products formed from hemangioblast cells (the other being pluripotent hemopoietic stem cells)." [CL:0000566, GOC:yaf]
synonym: "angioblastic mesenchymal cell differentiation" EXACT [CL:0000566]
is_a: GO:0048762 ! mesenchymal cell differentiation
relationship: part_of GO:0001568 ! blood vessel development
created_by: rfoulger
creation_date: 2011-04-04T11:10:38Z

[Term]
id: GO:0035780
name: CD80 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of CD80, a CD marker that occurs on antigen presenting cells such as activated B cells and monocytes that provides a co-stimulatory signal necessary for T cell activation and survival." [GOC:BHF, GOC:ebc]
synonym: "CD80 anabolism" EXACT [GOC:bf]
synonym: "CD80 biosynthesis" EXACT [GOC:bf]
synonym: "CD80 formation" EXACT [GOC:bf]
synonym: "CD80 synthesis" EXACT [GOC:bf]
is_a: GO:0009101 ! glycoprotein biosynthetic process
created_by: rfoulger
creation_date: 2011-04-04T11:18:41Z

[Term]
id: GO:0035781
name: CD86 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of CD86, a CD marker that occurs on antigen presenting cells that provides co-stimulatory signals necessary for T cell activation and survival." [GOC:BHF, GOC:ebc]
synonym: "CD86 anabolism" EXACT [GOC:bf]
synonym: "CD86 biosynthesis" EXACT [GOC:bf]
synonym: "CD86 formation" EXACT [GOC:bf]
synonym: "CD86 synthesis" EXACT [GOC:bf]
is_a: GO:0009101 ! glycoprotein biosynthetic process
created_by: rfoulger
creation_date: 2011-04-04T11:20:40Z

[Term]
id: GO:0035782
name: mature natural killer cell chemotaxis
namespace: biological_process
def: "The directed movement of a mature natural killer cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). A mature natural killer cell is a natural killer cell that is developmentally mature and expresses a variety of inhibitory and activating receptors that recognize MHC class and other stress related molecules." [CL:0000824, GOC:BHF]
synonym: "activated natural killer cell chemotaxis" EXACT [GOC:ebc]
is_a: GO:0035747 ! natural killer cell chemotaxis
created_by: rfoulger
creation_date: 2011-04-04T11:23:13Z

[Term]
id: GO:0035783
name: CD4-positive, alpha-beta T cell costimulation
namespace: biological_process
def: "The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment CD4-positive, alpha-beta T cell activation." [CL:0000624, GOC:BHF, GOC:pr]
synonym: "CD4-positive, alpha beta T cell costimulation" EXACT []
is_a: GO:0031295 ! T cell costimulation
is_a: GO:2000516 ! positive regulation of CD4-positive, alpha-beta T cell activation
created_by: rfoulger
creation_date: 2011-04-04T11:28:52Z

[Term]
id: GO:0035784
name: nickel cation homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of nickel cations within an organism or cell." [GOC:kmv]
synonym: "nickel homeostasis" EXACT [GOC:bf]
is_a: GO:0055076 ! transition metal ion homeostasis
is_a: GO:0072507 ! divalent inorganic cation homeostasis
created_by: rfoulger
creation_date: 2011-04-05T09:55:14Z

[Term]
id: GO:0035785
name: cellular nickel ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of nickel ions at the level of a cell." [GOC:kmv]
synonym: "cellular nickel homeostasis" EXACT [GOC:bf]
is_a: GO:0035784 ! nickel cation homeostasis
is_a: GO:0046916 ! cellular transition metal ion homeostasis
is_a: GO:0072503 ! cellular divalent inorganic cation homeostasis
created_by: rfoulger
creation_date: 2011-04-05T09:55:56Z

[Term]
id: GO:0035786
name: protein complex oligomerization
namespace: biological_process
def: "The association of two or more multisubunit protein complexes to form dimers or other multimers of a protein complex." [GOC:bf, GOC:mcc, PMID:18293929]
is_a: GO:0006461 ! protein complex assembly
created_by: rfoulger
creation_date: 2011-04-05T09:57:49Z

[Term]
id: GO:0035787
name: cell migration involved in kidney development
namespace: biological_process
def: "The orderly movement of a cell from one site to another that will contribute to the progression of the kidney over time, from its formation to the mature organ." [GOC:bf, GOC:mtg_kidney_jan10, GOC:yaf]
is_a: GO:0016477 ! cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: part_of GO:0001822 ! kidney development
relationship: part_of GO:0001822 ! kidney development
created_by: rfoulger
creation_date: 2011-04-06T10:39:52Z

[Term]
id: GO:0035788
name: cell migration involved in metanephros development
namespace: biological_process
def: "The orderly movement of a cell from one site to another that will contribute to the progression of the metanephric kidney over time, from its formation to the mature organ." [GOC:bf, GOC:mtg_kidney_jan10, GOC:yaf]
synonym: "cell migration involved in metanephric kidney development" EXACT [GOC:bf]
is_a: GO:0035787 ! cell migration involved in kidney development
intersection_of: GO:0016477 ! cell migration
intersection_of: part_of GO:0001656 ! metanephros development
relationship: part_of GO:0001656 ! metanephros development
created_by: rfoulger
creation_date: 2011-04-06T10:42:21Z

[Term]
id: GO:0035789
name: metanephric mesenchymal cell migration
namespace: biological_process
def: "The orderly movement of undifferentiated metanephric mesenchymal cells (precursors to metanephric mesangial cells) from the mesenchyme into the cleft of the developing glomerulus, during development of the metanephros." [GOC:bf, GOC:mtg_kidney_jan10, GOC:yaf, PMID:10734101, PMID:19019919]
synonym: "metanephric mesenchyme chemotaxis" NARROW [PMID:19019919]
is_a: GO:0035788 ! cell migration involved in metanephros development
created_by: rfoulger
creation_date: 2011-04-06T10:45:15Z

[Term]
id: GO:0035790
name: platelet-derived growth factor receptor-alpha signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of a ligand to an alpha-type platelet-derived growth factor receptor (PDGFalpha) on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:yaf, PMID:10372961, PR:000002030]
synonym: "alphaPDGF receptor signaling pathway" EXACT [PMID:10372961]
synonym: "PDGF receptor-alpha signaling pathway" EXACT [GOC:bf]
synonym: "PDGFR-alpha signaling pathway" RELATED [GOC:bf]
synonym: "platelet-derived growth factor receptor-alpha signalling pathway" EXACT [GOC:mah]
is_a: GO:0048008 ! platelet-derived growth factor receptor signaling pathway
created_by: rfoulger
creation_date: 2011-04-06T10:55:16Z

[Term]
id: GO:0035791
name: platelet-derived growth factor receptor-beta signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of a ligand to a beta-type platelet-derived growth factor receptor (PDGFbeta) on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:signaling, GOC:yaf, PMID:10372961, PR:000002035]
synonym: "betaPDGF receptor signaling pathway" EXACT [PMID:10372961]
synonym: "PDGF receptor-beta signaling pathway" EXACT [GOC:bf]
synonym: "PDGFR-beta signaling pathway" EXACT [GOC:bf]
synonym: "platelet-derived growth factor receptor-beta signalling pathway" EXACT [GOC:mah]
is_a: GO:0048008 ! platelet-derived growth factor receptor signaling pathway
created_by: rfoulger
creation_date: 2011-04-06T10:57:04Z

[Term]
id: GO:0035792
name: other organism postsynaptic membrane
namespace: cellular_component
def: "A postsynaptic membrane that is part of another organism, i.e. a secondary organism with which the first organism is interacting. A postsynaptic membrane is a specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters transmit the signal across the synaptic cleft to the postsynaptic membrane." [GOC:ecd]
synonym: "other organism post-synaptic membrane" EXACT []
is_a: GO:0044218 ! other organism cell membrane
created_by: rfoulger
creation_date: 2011-04-08T01:21:20Z

[Term]
id: GO:0035793
name: positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of metanephric mesenchymal cell migration as a result of the series of molecular signals generated as a consequence of a platelet-derived growth factor receptor-beta binding to one of its physiological ligands." [GOC:bf, GOC:mtg_kidney_jan10, GOC:yaf, PMID:10734101]
synonym: "positive regulation of metanephric mesenchymal cell migration by betaPDGF receptor signaling pathway" EXACT [PMID:10734101]
synonym: "positive regulation of metanephric mesenchymal cell migration by PDGF receptor-beta signaling pathway" EXACT [GOC:bf]
synonym: "positive regulation of metanephric mesenchymal cell migration by PDGFR-beta signaling pathway" EXACT [GOC:bf]
synonym: "positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signalling pathway" EXACT [GOC:mah]
is_a: GO:1900238 ! regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
is_a: GO:2000591 ! positive regulation of metanephric mesenchymal cell migration
intersection_of: GO:0035791 ! platelet-derived growth factor receptor-beta signaling pathway
intersection_of: positively_regulates GO:0035789 ! metanephric mesenchymal cell migration
relationship: positively_regulates GO:0035789 ! metanephric mesenchymal cell migration
created_by: rfoulger
creation_date: 2011-04-11T01:30:03Z

[Term]
id: GO:0035794
name: positive regulation of mitochondrial membrane permeability
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane." [GOC:bf, PMID:12546810]
synonym: "mitochondrial membrane permeability transition" NARROW [PMID:17136322]
synonym: "mitochondrial membrane permeabilization" NARROW [PMID:12546810]
synonym: "mitochondrial permeability transition" NARROW [PMID:21424245]
synonym: "MPT" NARROW []
synonym: "positive regulation of transport across mitochondrial membrane" EXACT [GOC:bf]
is_a: GO:0046902 ! regulation of mitochondrial membrane permeability
created_by: rfoulger
creation_date: 2011-04-11T01:44:06Z

[Term]
id: GO:0035795
name: negative regulation of mitochondrial membrane permeability
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane." [PMID:10781072]
synonym: "mitochondrial membrane impermeability" RELATED [PMID:10781072]
synonym: "mitochondrial membrane impermeabilization" NARROW [GOC:bf]
synonym: "negative regulation of transport across mitochondrial membrane" EXACT [GOC:bf]
is_a: GO:0046902 ! regulation of mitochondrial membrane permeability
created_by: rfoulger
creation_date: 2011-04-11T01:45:26Z

[Term]
id: GO:0035796
name: ATP-binding cassette (ABC) transporter complex, transmembrane substrate-binding subunit-containing
namespace: cellular_component
def: "A complex for the transport of metabolites into the cell, consisting of 4 subunits: a transmembrane substrate-binding protein (known as the S component), and an energy-coupling module that comprises two ATP-binding proteins (known as the A and A' components) and a transmembrane protein (known as the T component). Transport of the substrate across the membrane is driven by the hydrolysis of ATP." [PMID:18931129, PMID:20972419, PMID:21135102]
comment: The ECF-type transporters differs from other types of ABC transporters because the substrate-binding subunit lies integral to the membrane.
synonym: "ATP-binding cassette (ABC) transporter complex, ECF-type" EXACT [GOC:bf]
synonym: "energy coupling factor (ECF)-type ABC transporter" EXACT [PMID:21135102]
synonym: "energy-coupling factor transporter" EXACT [PMID:18931129]
is_a: GO:0043190 ! ATP-binding cassette (ABC) transporter complex
created_by: rfoulger
creation_date: 2011-04-11T02:02:41Z

[Term]
id: GO:0035797
name: tellurite methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to tellurite [TeO3(2-)]. Methylated derivatives of tellurite include Te(CH3)2 (dimethyltelluride) and Te2(CH3)2 (dimethylditelluride)." [CHEBI:30477, GOC:bf, GOC:kad, PMID:11053398, PMID:21244361]
synonym: "S-adenosyl-L-methionine-dependent tellurite methyltransferase activity" EXACT [GOC:bf]
synonym: "SAM-dependent tellurite methyltransferase activity" EXACT [GOC:bf]
synonym: "tellurite methylase activity" BROAD [GOC:bf]
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
created_by: rfoulger
creation_date: 2011-04-14T01:06:19Z

[Term]
id: GO:0035798
name: 2-alkenal reductase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: n-alkanal + NADP+ = alk-2-enal + NADPH + H+." [GOC:bf, GOC:kad, PMID:16299173]
synonym: "NADPH:2-alkenal alpha,beta-hydrogenase activity" EXACT [GOC:bf, GOC:kad]
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
created_by: rfoulger
creation_date: 2011-04-14T01:11:07Z

[Term]
id: GO:0035799
name: ureter maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the ureter to attain its fully functional state. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder or from the Malpighian tubule to the hindgut." [GOC:bf, GOC:mtg_kidney_jan10, GOC:yaf, PMID:17881463]
is_a: GO:0048799 ! organ maturation
relationship: part_of GO:0072189 ! ureter development
created_by: rfoulger
creation_date: 2011-04-14T01:13:39Z

[Term]
id: GO:0035800
name: deubiquitinase activator activity
namespace: molecular_function
def: "Increases the activity of deubiquitinase, an enzyme that catalyzes the hydrolysis of various forms of polymeric ubiquitin sequences." [GOC:sart, ISBN:0120793709]
is_a: GO:0016504 ! peptidase activator activity
relationship: part_of GO:2000158 ! positive regulation of ubiquitin-specific protease activity
creation_date: 2011-04-18T10:20:15Z

[Term]
id: GO:0035801
name: adrenal cortex development
namespace: biological_process
def: "The process whose specific outcome is the progression of the adrenal cortex over time, from its formation to the mature structure. The adrenal cortex is located at the periphery of the adrenal gland and controls glucose and electrolyte metabolism, response to stress and sexual development through the production of different classes of steroid hormones (glucocorticoids, mineralocorticoids and androgens)." [PMID:12185666, PMID:21115154, Wikipedia:Adrenal_cortex]
synonym: "adrenal gland cortex development" EXACT [MA:0000118]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0030325 ! adrenal gland development
created_by: rfoulger
creation_date: 2011-04-18T10:25:39Z

[Term]
id: GO:0035802
name: adrenal cortex formation
namespace: biological_process
def: "The process that gives rise to the adrenal cortex. This process pertains to the initial formation of a structure from unspecified parts. The adrenogonadal primordium from which the adrenal cortex is formed derives from a condensation of coelomic epithelial cells (the urogenital ridge; the same structure from which gonads and kidney also originate)." [PMID:12185666, PMID:21115154]
synonym: "adrenal gland cortex formation" EXACT [MA:0000118]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0035801 ! adrenal cortex development
created_by: rfoulger
creation_date: 2011-04-18T10:26:49Z

[Term]
id: GO:0035803
name: egg coat formation
namespace: biological_process
def: "Construction of an egg coat, a specialized extracellular matrix that surrounds the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development." [GOC:bf, GOC:sart, GOC:yaf, PMID:16944418, PMID:17163408]
synonym: "VE formation" NARROW [PMID:16944418, PMID:17163408]
synonym: "vitelline envelope formation" NARROW [PMID:16944418]
synonym: "zona pellucida assembly" NARROW [GOC:yaf, PMID:18420282]
synonym: "ZP assembly" NARROW [PMID:18420282]
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
relationship: part_of GO:0048477 ! oogenesis
created_by: rfoulger
creation_date: 2011-04-19T01:48:43Z

[Term]
id: GO:0035804
name: structural constituent of egg coat
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of an egg coat. An egg coat is a specialized extracellular matrix that surrounds the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development." [PMID:16944418, PMID:17163408]
synonym: "structural constituent of vitelline envelope" NARROW [PMID:16944418, PMID:17163408]
synonym: "structural constituent of zona pellucida" NARROW [PMID:16944418, PMID:17163408]
is_a: GO:0005198 ! structural molecule activity
created_by: rfoulger
creation_date: 2011-04-19T01:56:06Z

[Term]
id: GO:0035805
name: egg coat
namespace: cellular_component
def: "A specialized extracellular matrix that surrounds the plasma membrane of the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development." [PMID:16944418, PMID:17163408]
synonym: "vitelline membrane" NARROW [PMID:16944418, PMID:17163408]
synonym: "zona pellucida" NARROW [PMID:16944418, PMID:17163408]
is_a: GO:0030312 ! external encapsulating structure
created_by: rfoulger
creation_date: 2011-04-19T02:07:23Z

[Term]
id: GO:0035806
name: modulation of blood coagulation in other organism
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of blood coagulation in another organism. Blood coagulation is the sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot." [GOC:bf, GOC:fj]
synonym: "modulation by organism of blood clotting in other organism" EXACT [GOC:bf]
synonym: "modulation by organism of blood coagulation in other organism" EXACT [GOC:bf]
synonym: "regulation by organism of blood clotting in other organism" EXACT [GOC:bf]
synonym: "regulation of blood clotting in other organism" EXACT [GOC:bf]
synonym: "regulation of blood coagulation in other organism" EXACT [GOC:bf]
is_a: GO:0030193 ! regulation of blood coagulation
is_a: GO:0035821 ! modification of morphology or physiology of other organism
created_by: rfoulger
creation_date: 2011-04-20T11:38:49Z

[Term]
id: GO:0035807
name: positive regulation of blood coagulation in other organism
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of blood coagulation in another organism. Blood coagulation is the sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot." [GOC:bf, GOC:fj, PMID:12362232]
synonym: "positive regulation by organism of blood clotting in other organism" EXACT [GOC:bf]
synonym: "positive regulation by organism of blood coagulation in other organism" EXACT [GOC:bf]
synonym: "positive regulation of blood clotting in other organism" EXACT [GOC:bf]
is_a: GO:0030194 ! positive regulation of blood coagulation
is_a: GO:0035806 ! modulation of blood coagulation in other organism
created_by: rfoulger
creation_date: 2011-04-20T11:43:37Z

[Term]
id: GO:0035808
name: meiotic recombination initiation complex
namespace: cellular_component
def: "A protein complex that initiates the formation of double-strand breaks (DSBs) required for meiotic recombination. Consists of a protein that catalyses formation of the double-strand breaks (Spo11 in S. cerevisiae and Rec12 in S. pombe), and a number of accessory proteins." [GOC:vw, PMID:12897161, PMID:20364342, PMID:21429938]
is_a: GO:0043234 ! protein complex
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000794 ! condensed nuclear chromosome
created_by: rfoulger
creation_date: 2011-04-20T11:52:50Z

[Term]
id: GO:0035809
name: regulation of urine volume
namespace: biological_process
def: "Any process that modulates the amount of urine excreted from the body over a unit of time." [GOC:mtg_25march11, GOC:yaf]
synonym: "regulation of urinary volume" EXACT []
synonym: "regulation of urine flow" EXACT []
is_a: GO:0003014 ! renal system process
is_a: GO:0050878 ! regulation of body fluid levels
created_by: rfoulger
creation_date: 2011-04-20T01:17:38Z

[Term]
id: GO:0035810
name: positive regulation of urine volume
namespace: biological_process
def: "Any process that increases the amount of urine excreted from the body over a unit of time." [GOC:mtg_25march11, GOC:yaf]
synonym: "diuresis" BROAD [GOC:mtg_25march11]
synonym: "elevation of urinary volume" EXACT [GOC:mtg_25march11]
synonym: "increase in urine flow" EXACT [GOC:mtg_25march11]
is_a: GO:0035809 ! regulation of urine volume
created_by: rfoulger
creation_date: 2011-04-20T01:19:38Z

[Term]
id: GO:0035811
name: negative regulation of urine volume
namespace: biological_process
def: "Any process that decreases the amount of urine excreted from the body over a unit of time." [GOC:mtg_25march11, GOC:yaf]
synonym: "antidiuresis" BROAD [GOC:mtg_25march11]
synonym: "decrease in urine flow" EXACT [GOC:mtg_25march11]
synonym: "reduction of urinary volume" EXACT [GOC:mtg_25march11]
is_a: GO:0035809 ! regulation of urine volume
created_by: rfoulger
creation_date: 2011-04-20T01:21:01Z

[Term]
id: GO:0035812
name: renal sodium excretion
namespace: biological_process
def: "The elimination by an organism of sodium in the urine." [GOC:mtg_25march11, GOC:yaf]
is_a: GO:0003014 ! renal system process
is_a: GO:0007588 ! excretion
relationship: part_of GO:0055078 ! sodium ion homeostasis
created_by: rfoulger
creation_date: 2011-04-20T01:24:16Z

[Term]
id: GO:0035813
name: regulation of renal sodium excretion
namespace: biological_process
def: "Any process that modulates the amount of sodium excreted in urine over a unit of time." [GOC:mtg_25march11, GOC:yaf]
is_a: GO:0044062 ! regulation of excretion
is_a: GO:0098801 ! regulation of renal system process
is_a: GO:2000021 ! regulation of ion homeostasis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035812 ! renal sodium excretion
relationship: regulates GO:0035812 ! renal sodium excretion
created_by: rfoulger
creation_date: 2011-04-20T01:26:30Z

[Term]
id: GO:0035814
name: negative regulation of renal sodium excretion
namespace: biological_process
def: "Any process that decreases the amount of sodium excreted in urine over a unit of time." [GOC:mtg_25march11, GOC:yaf]
comment: The amount of sodium excreted in urine over a unit of time can be decreased by decreasing the volume of urine produced (antidiuresis) and/or by decreasing the concentration of sodium in the urine.
is_a: GO:0032845 ! negative regulation of homeostatic process
is_a: GO:0035813 ! regulation of renal sodium excretion
is_a: GO:0051048 ! negative regulation of secretion
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035812 ! renal sodium excretion
relationship: negatively_regulates GO:0035812 ! renal sodium excretion
created_by: rfoulger
creation_date: 2011-04-20T01:27:39Z

[Term]
id: GO:0035815
name: positive regulation of renal sodium excretion
namespace: biological_process
def: "Any process that increases the amount of sodium excreted in urine over a unit of time." [GOC:mtg_25march11, GOC:yaf]
comment: The amount of sodium excreted in urine over a unit of time can be increased by increasing the volume of urine produced (diuresis) and/or by increasing the concentration of sodium in the urine.
synonym: "natriuresis" BROAD [GOC:mtg_25march11]
is_a: GO:0032846 ! positive regulation of homeostatic process
is_a: GO:0035813 ! regulation of renal sodium excretion
is_a: GO:0051047 ! positive regulation of secretion
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035812 ! renal sodium excretion
relationship: positively_regulates GO:0035812 ! renal sodium excretion
created_by: rfoulger
creation_date: 2011-04-20T01:29:26Z

[Term]
id: GO:0035816
name: renal water absorption involved in negative regulation of urine volume
namespace: biological_process
def: "Any process where water is taken up from the collecting ducts and proximal and distal loops of the nephron, which acts to decrease the amount of urine that is excreted from the body per unit time." [GOC:mtg_25march11, GOC:yaf]
is_a: GO:0070295 ! renal water absorption
intersection_of: GO:0070295 ! renal water absorption
intersection_of: part_of GO:0035811 ! negative regulation of urine volume
relationship: part_of GO:0035811 ! negative regulation of urine volume
created_by: rfoulger
creation_date: 2011-04-20T01:37:34Z

[Term]
id: GO:0035817
name: renal sodium ion absorption involved in negative regulation of renal sodium excretion
namespace: biological_process
def: "Any process where sodium ions are taken up from the collecting ducts and proximal and distal loops of the nephron, which contributes to decreasing the amount of sodium that is excreted in urine per unit time." [GOC:mtg_25march11, GOC:yaf]
is_a: GO:0070294 ! renal sodium ion absorption
intersection_of: GO:0070294 ! renal sodium ion absorption
intersection_of: part_of GO:0035814 ! negative regulation of renal sodium excretion
relationship: part_of GO:0035814 ! negative regulation of renal sodium excretion
created_by: rfoulger
creation_date: 2011-04-20T01:40:11Z

[Term]
id: GO:0035818
name: positive regulation of urine volume by pressure natriuresis
namespace: biological_process
def: "An increase in the amount of urine excreted over a unit of time, as a result of pressure natriuresis." [GOC:mtg_25march11, GOC:yaf]
synonym: "diuresis resulting from pressure natriuresis" RELATED [GOC:mtg_25march11]
is_a: GO:0003095 ! pressure natriuresis
is_a: GO:0035810 ! positive regulation of urine volume
created_by: rfoulger
creation_date: 2011-04-20T01:55:42Z

[Term]
id: GO:0035819
name: positive regulation of renal sodium excretion by pressure natriuresis
namespace: biological_process
def: "An increase in the amount of sodium excreted in urine over a unit of time, as a result of pressure natriuresis." [GOC:mtg_25march11, GOC:yaf]
synonym: "natriuresis resulting from pressure natriuresis" RELATED []
is_a: GO:0003095 ! pressure natriuresis
is_a: GO:0035815 ! positive regulation of renal sodium excretion
intersection_of: GO:0003095 ! pressure natriuresis
intersection_of: positively_regulates GO:0035812 ! renal sodium excretion
relationship: positively_regulates GO:0035812 ! renal sodium excretion
created_by: rfoulger
creation_date: 2011-04-20T01:57:20Z

[Term]
id: GO:0035820
name: negative regulation of renal sodium excretion by angiotensin
namespace: biological_process
def: "The process in which angiotensin decreases the amount of sodium that is excreted in urine over a unit of time." [GOC:mtg_25march11, GOC:yaf]
is_a: GO:0003083 ! negative regulation of renal output by angiotensin
is_a: GO:0035814 ! negative regulation of renal sodium excretion
created_by: rfoulger
creation_date: 2011-04-20T02:10:50Z

[Term]
id: GO:0035821
name: modification of morphology or physiology of other organism
namespace: biological_process
def: "The process in which an organism effects a change in the structure or processes of a second organism." [GOC:bf]
synonym: "regulation of morphology of other organism" NARROW [GOC:bf]
synonym: "regulation of morphology or physiology of other organism" RELATED [GOC:bf]
synonym: "regulation of physiological process of other organism" NARROW [GOC:bf]
synonym: "regulation of physiology of other organism" NARROW [GOC:bf]
is_a: GO:0051704 ! multi-organism process
is_a: GO:0065008 ! regulation of biological quality
created_by: rfoulger
creation_date: 2011-04-21T01:31:51Z

[Term]
id: GO:0035822
name: gene conversion
namespace: biological_process
def: "A DNA recombination process that results in the unidirectional transfer of genetic material from a donor sequence to a highly homologous acceptor." [GOC:mah, PMID:17846636]
is_a: GO:0006310 ! DNA recombination
created_by: rfoulger
creation_date: 2011-05-04T01:04:39Z

[Term]
id: GO:0035823
name: short tract gene conversion
namespace: biological_process
def: "A gene conversion process in which a segment of about 50-200 base pairs is transferred from the donor to the acceptor." [GOC:mah, PMID:16954385]
is_a: GO:0035822 ! gene conversion
created_by: rfoulger
creation_date: 2011-05-04T01:05:35Z

[Term]
id: GO:0035824
name: long tract gene conversion
namespace: biological_process
def: "A gene conversion process in which a segment of more than 1000 base pairs is transferred from the donor to the acceptor." [GOC:mah, PMID:16954385]
is_a: GO:0035822 ! gene conversion
created_by: rfoulger
creation_date: 2011-05-04T01:06:18Z

[Term]
id: GO:0035825
name: reciprocal DNA recombination
namespace: biological_process
def: "A DNA recombination process that results in the equal exchange of genetic material between the recombining DNA molecules." [GOC:mah, PMID:11139492, PMID:17304215]
synonym: "chromosomal crossover" EXACT [GOC:mah, Wikipedia:Chromosomal_crossover]
xref: Wikipedia:Chromosomal_crossover
is_a: GO:0006310 ! DNA recombination
created_by: rfoulger
creation_date: 2011-05-04T01:23:31Z

[Term]
id: GO:0035826
name: rubidium ion transport
namespace: biological_process
def: "The directed movement of rubidium ions (Rb+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:49847, GOC:yaf]
synonym: "Rb+ transport" EXACT [CHEBI:49847]
synonym: "rubidium cation transport" EXACT [CHEBI:49847]
is_a: GO:0015672 ! monovalent inorganic cation transport
is_a: GO:0030001 ! metal ion transport
created_by: rfoulger
creation_date: 2011-05-04T02:53:27Z

[Term]
id: GO:0035827
name: rubidium ion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of rubidium ions (Rb+) from one side of a membrane to the other." [CHEBI:49847, GOC:yaf]
synonym: "Rb+ transmembrane transporter activity" EXACT [CHEBI:49847]
synonym: "rubidium cation transmembrane transporter activity" EXACT [CHEBI:49847]
synonym: "rubidium transmembrane transporter activity" RELATED [GOC:bf]
is_a: GO:0015077 ! monovalent inorganic cation transmembrane transporter activity
is_a: GO:0046873 ! metal ion transmembrane transporter activity
relationship: part_of GO:0035826 ! rubidium ion transport
created_by: rfoulger
creation_date: 2011-05-04T02:55:30Z

[Term]
id: GO:0035828
name: renal rubidium ion transport
namespace: biological_process
def: "The directed movement of rubidium ions (Rb+) by the kidney." [CHEBI:49847, GOC:yaf]
synonym: "renal Rb+ transport" EXACT [CHEBI:49847]
synonym: "renal rubidium cation transport" EXACT [CHEBI:49847]
is_a: GO:0003014 ! renal system process
is_a: GO:0035826 ! rubidium ion transport
is_a: GO:0044707 ! single-multicellular organism process
created_by: rfoulger
creation_date: 2011-05-04T02:58:50Z

[Term]
id: GO:0035829
name: renal rubidium ion absorption
namespace: biological_process
def: "A renal system process in which rubidium ions are taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures." [CHEBI:49847, GOC:yaf]
synonym: "renal Rb+ absorption" EXACT [CHEBI:49847]
synonym: "renal rubidium cation absorption" EXACT [CHEBI:49847]
is_a: GO:0035828 ! renal rubidium ion transport
is_a: GO:0070293 ! renal absorption
created_by: rfoulger
creation_date: 2011-05-04T03:01:05Z

[Term]
id: GO:0035830
name: palmatine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving palmatine, a berberine alkaloid found in many plants." [CHEBI:16096, GOC:yaf]
synonym: "palmatine metabolism" EXACT [GOC:bf]
is_a: GO:0033076 ! isoquinoline alkaloid metabolic process
created_by: rfoulger
creation_date: 2011-05-04T03:04:38Z

[Term]
id: GO:0035831
name: palmatine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of palmatine, a berberine alkaloid found in many plants." [CHEBI:16096, GOC:yaf]
synonym: "palmatine anabolism" EXACT [GOC:bf]
synonym: "palmatine biosynthesis" EXACT [GOC:bf]
synonym: "palmatine formation" EXACT [GOC:bf]
synonym: "palmatine synthesis" EXACT [GOC:bf]
is_a: GO:0033075 ! isoquinoline alkaloid biosynthetic process
is_a: GO:0035830 ! palmatine metabolic process
created_by: rfoulger
creation_date: 2011-05-04T03:06:06Z

[Term]
id: GO:0035832
name: berbamunine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving berbamunine, an isoquinoline alkaloid." [CHEBI:16777, GOC:yaf]
synonym: "berbamunine metabolism" EXACT [GOC:bf]
is_a: GO:0046445 ! benzyl isoquinoline alkaloid metabolic process
is_a: GO:0097164 ! ammonium ion metabolic process
created_by: rfoulger
creation_date: 2011-05-04T03:11:18Z

[Term]
id: GO:0035833
name: berbamunine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of berbamunine, an isoquinoline alkaloid." [CHEBI:16777, GOC:yaf]
synonym: "berbamunine anabolism" EXACT [GOC:bf]
synonym: "berbamunine biosynthesis" EXACT [GOC:bf]
synonym: "berbamunine formation" EXACT [GOC:bf]
synonym: "berbamunine synthesis" EXACT [GOC:bf]
is_a: GO:0009708 ! benzyl isoquinoline alkaloid biosynthetic process
is_a: GO:0035832 ! berbamunine metabolic process
created_by: rfoulger
creation_date: 2011-05-04T03:12:03Z

[Term]
id: GO:0035834
name: indole alkaloid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an indole alkaloid, an alkaloid containing an indole skeleton." [CHEBI:38958, GOC:yaf]
synonym: "indole alkaloid metabolism" EXACT [GOC:bf]
is_a: GO:0009820 ! alkaloid metabolic process
created_by: rfoulger
creation_date: 2011-05-04T03:17:44Z

[Term]
id: GO:0035835
name: indole alkaloid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an indole alkaloid, an alkaloid containing an indole skeleton." [CHEBI:38958, GOC:yaf]
synonym: "indole alkaloid anabolism" EXACT [GOC:bf]
synonym: "indole alkaloid biosynthesis" EXACT [GOC:bf]
synonym: "indole alkaloid formation" EXACT [GOC:bf]
synonym: "indole alkaloid synthesis" EXACT [GOC:bf]
is_a: GO:0009821 ! alkaloid biosynthetic process
is_a: GO:0035834 ! indole alkaloid metabolic process
created_by: rfoulger
creation_date: 2011-05-04T03:18:31Z

[Term]
id: GO:0035836
name: ergot alkaloid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an ergot alkaloid, an indole alkaloid." [CHEBI:23943, GOC:yaf]
synonym: "ergot alkaloid metabolism" EXACT [GOC:bf]
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0046447 ! terpenoid indole alkaloid metabolic process
created_by: rfoulger
creation_date: 2011-05-04T03:23:13Z

[Term]
id: GO:0035837
name: ergot alkaloid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an ergot alkaloid." [CHEBI:23943, GOC:yaf]
synonym: "ergot alkaloid anabolism" EXACT [GOC:bf]
synonym: "ergot alkaloid biosynthesis" EXACT [GOC:bf]
synonym: "ergot alkaloid formation" EXACT [GOC:bf]
synonym: "ergot alkaloid synthesis" EXACT [GOC:bf]
is_a: GO:0009709 ! terpenoid indole alkaloid biosynthetic process
is_a: GO:0035836 ! ergot alkaloid metabolic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:0044763 ! single-organism cellular process
created_by: rfoulger
creation_date: 2011-05-04T03:23:57Z

[Term]
id: GO:0035838
name: growing cell tip
namespace: cellular_component
def: "The region at either end of the longest axis of a cylindrical or elongated cell, where polarized growth occurs." [GOC:mah]
synonym: "growing cell end" EXACT [GOC:mah]
is_a: GO:0030427 ! site of polarized growth
is_a: GO:0051286 ! cell tip
created_by: rfoulger
creation_date: 2011-05-06T01:28:44Z

[Term]
id: GO:0035839
name: non-growing cell tip
namespace: cellular_component
def: "A cell tip at which no growth takes place. For example, in fission yeast the cell end newly formed by cell division does not grow immediately upon its formation, and lacks actin cytoskeletal structures." [GOC:expert_jd, GOC:mah]
synonym: "new cell end" RELATED [GOC:mah]
synonym: "non-growing cell end" EXACT [GOC:mah]
is_a: GO:0051286 ! cell tip
created_by: rfoulger
creation_date: 2011-05-06T01:32:21Z

[Term]
id: GO:0035840
name: old growing cell tip
namespace: cellular_component
def: "A cell tip which has existed for at least one complete cell cycle, and at which polarized growth occurs. For example, in fission yeast the cell end that existed prior to cell division grows immediately after division, and contains a distinctive complement of proteins including actin cytoskeletal structures." [GOC:expert_jd, GOC:mah]
synonym: "old growing cell end" EXACT [GOC:mah]
is_a: GO:0035838 ! growing cell tip
created_by: rfoulger
creation_date: 2011-05-06T01:33:54Z

[Term]
id: GO:0035841
name: new growing cell tip
namespace: cellular_component
def: "A cell tip that was newly formed at the last cell division, and that has started to grow after the cell has activated bipolar cell growth (i.e. in which new end take-off, NETO, has taken place). New end take-off is when monopolar cells initiate bipolar growth." [GOC:expert_jd, GOC:mah, PMID:19431238]
synonym: "new cell tip after activation of bipolar cell growth" EXACT [GOC:bf]
synonym: "post-NETO new cell end" EXACT [GOC:mah]
synonym: "post-NETO new cell tip" EXACT [GOC:mah]
synonym: "post-new end take-off new cell tip" EXACT [GOC:mah]
is_a: GO:0035838 ! growing cell tip
created_by: rfoulger
creation_date: 2011-05-06T01:35:07Z

[Term]
id: GO:0035842
name: old cell tip after activation of bipolar cell growth
namespace: cellular_component
def: "A cell tip which has existed for at least one complete cell cycle, and at which polarized growth occurs, which is part of a cell that has activated bipolar cell growth (i.e. in which new end take-off, NETO, has taken place). For example, in fission yeast the cell end that existed prior to cell division grows immediately after division, and contains a distinctive complement of proteins including actin cytoskeletal structures." [GOC:expert_jd, GOC:mah]
synonym: "post-NETO old cell end" EXACT [GOC:mah]
synonym: "post-NETO old cell tip" EXACT [GOC:mah]
synonym: "post-new end take-off old cell tip" EXACT [GOC:mah]
is_a: GO:0035840 ! old growing cell tip
created_by: rfoulger
creation_date: 2011-05-06T01:37:23Z

[Term]
id: GO:0035843
name: endonuclear canal
namespace: cellular_component
def: "A membrane-bound structure present in the nucleus of a spermatozoon. There is variation in the number of endonuclear canals between sperm of different organisms, and some species lack these structures altogether. The endonuclear canal may provide a supporting role for the sperm nucleus, and originates during spermiogenesis from an invagination of the nuclear envelope." [GOC:bf, PMID:18359585]
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0001673 ! male germ cell nucleus
created_by: rfoulger
creation_date: 2011-05-06T01:45:03Z

[Term]
id: GO:0035844
name: cloaca development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cloaca over time, from it's formation to the mature structure. The cloaca is the common chamber into which intestinal, genital and urinary canals open in vertebrates." [GOC:dgh, ISBN:0582227089]
synonym: "cloacal development" EXACT [GOC:bf]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0001655 ! urogenital system development
relationship: part_of GO:0048546 ! digestive tract morphogenesis
created_by: rfoulger
creation_date: 2011-05-06T01:54:35Z

[Term]
id: GO:0035845
name: photoreceptor cell outer segment organization
namespace: biological_process
def: "A process that is carried out at the cellular level and results in the assembly, arrangement of constituent parts, or disassembly of the outer segment of a photoreceptor cell, a sensory cell that reacts to the presence of light. The outer segment of the photoreceptor cell contains the light-absorbing materials." [ISBN:0824072820, PMID:14507858]
synonym: "photoreceptor cell outer segment organisation" EXACT [GOC:mah]
synonym: "photoreceptor outer segment organization" EXACT [GOC:bf]
is_a: GO:0044782 ! cilium organization
relationship: part_of GO:0042461 ! photoreceptor cell development
created_by: rfoulger
creation_date: 2011-05-10T10:44:09Z

[Term]
id: GO:0035846
name: oviduct epithelium development
namespace: biological_process
def: "The progression of the oviduct epithelium over time from its initial formation to the mature structure. An oviduct is a tube through which an ova passes from the ovary to the uterus, or from the ovary to the outside of the organism. The oviduct epithelium is the specialized epithelium that lines the oviduct." [GOC:yaf, http://www.thefreedictionary.com/oviduct]
synonym: "fallopian tube epithelium development" NARROW [GOC:yaf]
is_a: GO:0048608 ! reproductive structure development
is_a: GO:0060429 ! epithelium development
relationship: part_of GO:0060066 ! oviduct development
created_by: rfoulger
creation_date: 2011-05-10T10:53:05Z

[Term]
id: GO:0035847
name: uterine epithelium development
namespace: biological_process
def: "The progression of an epithelium of the uterus over time from its initial formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:bf, GOC:yaf]
synonym: "uterus epithelial development" EXACT [GOC:yaf]
is_a: GO:0035846 ! oviduct epithelium development
relationship: part_of GO:0060065 ! uterus development
created_by: rfoulger
creation_date: 2011-05-10T10:57:45Z

[Term]
id: GO:0035848
name: oviduct morphogenesis
namespace: biological_process
def: "The process in which anatomical structures of the oviduct are generated and organized. An oviduct is a tube through which an ova passes from the ovary to the uterus, or from the ovary to the outside of the organism." [GOC:yaf, http://www.thefreedictionary.com/oviduct]
synonym: "fallopian tube morphogenesis" NARROW [GOC:yaf]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0009887 ! organ morphogenesis
is_a: GO:0035239 ! tube morphogenesis
is_a: GO:0044702 ! single organism reproductive process
relationship: part_of GO:0060066 ! oviduct development
created_by: rfoulger
creation_date: 2011-05-10T11:01:20Z

[Term]
id: GO:0035849
name: nephric duct elongation
namespace: biological_process
def: "The process in which the nephric duct grows along its axis. A nephric duct is a tube that drains a primitive kidney." [GOC:mtg_kidney_jan10, GOC:yaf, PMID:16216236]
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0072178 ! nephric duct morphogenesis
created_by: rfoulger
creation_date: 2011-05-11T11:31:39Z

[Term]
id: GO:0035850
name: epithelial cell differentiation involved in kidney development
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an epithelial cell that characterize the cells of the kidney as it progresses from its formation to the mature state." [GOC:bf, GOC:mtg_kidney_jan10, GOC:yaf, PMID:16216236]
is_a: GO:0030855 ! epithelial cell differentiation
is_a: GO:0061005 ! cell differentiation involved in kidney development
intersection_of: GO:0030855 ! epithelial cell differentiation
intersection_of: part_of GO:0001822 ! kidney development
relationship: part_of GO:0001822 ! kidney development
created_by: rfoulger
creation_date: 2011-05-11T11:34:21Z

[Term]
id: GO:0035851
name: Krueppel-associated box domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a Krueppel-associated box (KRAB) domain of a protein. The approximately 75 amino acid KRAB domain is enriched in charged amino acids, and is found in the N-terminal regions of many zinc finger-containing transcription factors." [InterPro:IPR001909]
synonym: "KRAB domain binding" EXACT [InterPro:IPR001909]
synonym: "Krueppel-associated box binding" EXACT [InterPro:IPR001909]
is_a: GO:0019904 ! protein domain specific binding
created_by: rfoulger
creation_date: 2011-05-11T11:41:16Z

[Term]
id: GO:0035852
name: horizontal cell localization
namespace: biological_process
def: "Any process in which a horizontal cell is transported to, and/or maintained in, a specific location within the inner nuclear layer (INL) of the retina. A horizontal cell is a neuron that laterally connects other neurons in the inner nuclear layer (INL) of the retina. Targeting of retinal neurons to the appropriate lamina is vital to establish the architecture of the retina." [CL:0000745, GOC:bf, GOC:yaf, PMID:18094249]
synonym: "horizontal cell localisation" EXACT [GOC:mah]
synonym: "horizontal cell positioning" EXACT [PMID:18094249]
synonym: "laminar positioning of retinal horizontal cell" EXACT [PMID:18094249]
synonym: "retinal horizontal cell positioning" EXACT [PMID:18094249]
is_a: GO:0051674 ! localization of cell
relationship: part_of GO:0010842 ! retina layer formation
created_by: rfoulger
creation_date: 2011-05-11T01:56:40Z

[Term]
id: GO:0035853
name: chromosome passenger complex localization to spindle midzone
namespace: biological_process
def: "A cellular protein complex localization that acts on a chromosome passenger complex; as a result, the complex is transported to, or maintained in, a specific location at the spindle midzone. A chromosome passenger complex is a protein complex that contains the BIR-domain-containing protein Survivin, Aurora B kinase, INCENP and Borealin, and coordinates various events based on its location to different structures during the course of mitosis. The spindle midzone is the area in the center of the spindle where the spindle microtubules from opposite poles overlap." [GOC:mah, GOC:vw, PMID:15296749]
synonym: "chromosomal passenger complex localization to spindle midzone" EXACT [GOC:bf]
synonym: "chromosome passenger complex localisation to spindle midzone" EXACT [GOC:bf]
synonym: "chromosome passenger complex localization to central spindle" EXACT [PMID:14528012]
synonym: "chromosome passenger complex localization to spindle equator" EXACT [GOC:bf]
synonym: "CPC complex localization to spindle midzone" EXACT [GOC:bf]
synonym: "CPC localization to spindle midzone" EXACT [GOC:bf]
is_a: GO:0034629 ! cellular protein complex localization
is_a: GO:0044380 ! protein localization to cytoskeleton
created_by: rfoulger
creation_date: 2011-05-13T01:19:51Z

[Term]
id: GO:0035854
name: eosinophil fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a eosinophil cell. A eosinophil is any of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin." [CL:0000771, GOC:BHF, GOC:vk]
synonym: "eosinophil cell fate commitment" EXACT [GOC:bf]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0030222 ! eosinophil differentiation
created_by: rfoulger
creation_date: 2011-05-13T01:23:28Z

[Term]
id: GO:0035855
name: megakaryocyte development
namespace: biological_process
def: "The process whose specific outcome is the progression of a megakaryocyte cell over time, from its formation to the mature structure. Megakaryocyte development does not include the steps involved in committing a cell to a megakaryocyte fate. A megakaryocyte is a giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow." [CL:0000556, GOC:BHF, GOC:vk]
synonym: "megakaryocyte cell development" EXACT [GOC:bf]
is_a: GO:0061515 ! myeloid cell development
is_a: GO:0098751 ! bone cell development
relationship: part_of GO:0030219 ! megakaryocyte differentiation
created_by: rfoulger
creation_date: 2011-05-13T01:28:06Z

[Term]
id: GO:0035857
name: eosinophil fate specification
namespace: biological_process
def: "The process involved in the specification of identity of an eosinophil cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment." [CL:0000771, GOC:BHF, GOC:vk]
synonym: "eosinophil cell fate specification" EXACT [GOC:bf]
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0035854 ! eosinophil fate commitment
created_by: rfoulger
creation_date: 2011-05-17T10:42:54Z

[Term]
id: GO:0035858
name: eosinophil fate determination
namespace: biological_process
def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into an eosinophil cell regardless of its environment; upon determination, the cell fate cannot be reversed." [CL:0000771, GOC:BHF, GOC:vk]
synonym: "eosinophil cell fate determination" EXACT [GOC:bf]
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0035854 ! eosinophil fate commitment
created_by: rfoulger
creation_date: 2011-05-17T10:43:35Z

[Term]
id: GO:0035859
name: Seh1-associated complex
namespace: cellular_component
def: "A protein complex that associates dynamically with the vacuolar membrane, and is proposed to have a role in membrane-associated trafficking or regulatory processes. In S. cerevisiae the complex contains Seh1p, Sec13p, Npr2p, Npr3p, Iml1p, Mtc5p, Rtc1p, and Sea4p." [GOC:jh, PMID:21454883, PMID:23974112]
synonym: "GATOR complex" EXACT [GOC:rb, PMID:23723238]
synonym: "SEA complex" EXACT [GOC:jh, PMID:21454883]
is_a: GO:0043234 ! protein complex
created_by: rfoulger
creation_date: 2011-05-17T10:59:50Z

[Term]
id: GO:0035860
name: glial cell-derived neurotrophic factor receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a glial cell-derived neurotrophic factor receptor binding to one of its physiological ligands." [GOC:yaf, PMID:12953054]
synonym: "GDNF receptor signaling pathway" EXACT [GOC:yaf]
synonym: "glial cell derived neurotrophic factor receptor signaling pathway" EXACT [GOC:bf]
synonym: "glial cell line-derived neurotrophic factor receptor signalling pathway" EXACT [GOC:yaf]
synonym: "glial cell-derived neurotrophic factor receptor signalling pathway" EXACT [GOC:bf]
is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway
created_by: rfoulger
creation_date: 2011-05-17T11:01:33Z

[Term]
id: GO:0035861
name: site of double-strand break
namespace: cellular_component
def: "A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408]
synonym: "DNA damage foci" RELATED [GOC:vw]
synonym: "DNA damage focus" RELATED [GOC:mah, PMID:20096808, PMID:21035408]
synonym: "ionizing radiation-induced foci" RELATED [PMID:20096808, PMID:21035408]
synonym: "IRIF" RELATED [PMID:20096808, PMID:21035408]
synonym: "site of DSB" EXACT [PMID:21035408]
is_a: GO:0044427 ! chromosomal part
created_by: rfoulger
creation_date: 2011-05-17T03:04:42Z

[Term]
id: GO:0035862
name: dITP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dITP (deoxyinosine triphosphate (2'-deoxyinosine 5'-triphosphate). dITP is a deoxyinosine phosphate compound having a triphosphate group at the 5'-position." [CHEBI:28807, GOC:bf]
synonym: "2'-Deoxyinosine 5'-triphosphate metabolic process" EXACT [CHEBI:28807]
synonym: "2'-Deoxyinosine-5'-triphosphate metabolic process" EXACT [CHEBI:28807]
synonym: "deoxyinosine 5'-triphosphate metabolic process" EXACT [CHEBI:28807]
synonym: "deoxyinosine triphosphate (2'-deoxyinosine 5'-triphosphate) metabolic process" EXACT [GOC:dgf]
synonym: "dITP metabolism" EXACT [GOC:bf]
is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process
is_a: GO:0009215 ! purine deoxyribonucleoside triphosphate metabolic process
created_by: rfoulger
creation_date: 2011-05-25T02:52:58Z

[Term]
id: GO:0035863
name: dITP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dITP, a deoxyinosine phosphate compound having a triphosphate group at the 5'-position." [CHEBI:28807, GOC:dgf]
synonym: "2'-Deoxyinosine 5'-triphosphate catabolic process" EXACT [CHEBI:28807]
synonym: "2'-Deoxyinosine-5'-triphosphate catabolic process" EXACT [CHEBI:28807]
synonym: "deoxyinosine 5'-triphosphate catabolic process" EXACT [CHEBI:28807]
synonym: "deoxyinosine triphosphate (2'-deoxyinosine 5'-triphosphate) catabolic process" EXACT [GOC:dgf]
synonym: "dITP breakdown" EXACT [GOC:bf]
synonym: "dITP catabolism" EXACT [GOC:bf]
synonym: "dITP degradation" EXACT [GOC:bf]
is_a: GO:0009155 ! purine deoxyribonucleotide catabolic process
is_a: GO:0009217 ! purine deoxyribonucleoside triphosphate catabolic process
is_a: GO:0035862 ! dITP metabolic process
created_by: rfoulger
creation_date: 2011-05-25T02:55:21Z

[Term]
id: GO:0035864
name: response to potassium ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus." [GOC:yaf]
synonym: "response to K+ ion" EXACT [GOC:bf]
synonym: "response to potassium" EXACT [GOC:bf]
is_a: GO:0010038 ! response to metal ion
created_by: rfoulger
creation_date: 2011-05-25T02:58:45Z

[Term]
id: GO:0035865
name: cellular response to potassium ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus." [GOC:yaf]
synonym: "cellular response to K+ ion" EXACT [GOC:bf]
synonym: "cellular response to potassium" EXACT [GOC:bf]
is_a: GO:0035864 ! response to potassium ion
is_a: GO:0071248 ! cellular response to metal ion
created_by: rfoulger
creation_date: 2011-05-25T02:59:11Z

[Term]
id: GO:0035866
name: alphav-beta3 integrin-PKCalpha complex
namespace: cellular_component
def: "A protein complex that consists of an alphav-beta3 integrin complex bound to protein kinase C alpha." [GOC:BHF, GOC:ebc, PMID:16014375]
synonym: "alphav-beta3 integrin-PKCa complex" EXACT [GOC:ebc]
synonym: "alphav-beta3 integrin-protein kinase C alpha complex" EXACT [GOC:bf]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: rfoulger
creation_date: 2011-05-25T03:03:59Z

[Term]
id: GO:0035867
name: alphav-beta3 integrin-IGF-1-IGF1R complex
namespace: cellular_component
def: "A protein complex that consists of an alphav-beta3 integrin complex bound to insulin-like growth factor-1 (IGF-1) and type I insulin-like growth factor receptor (IGF1R). IGF1R is a heterotetramer that consists of two alpha-subunits and two beta-subunits." [GOC:BHF, GOC:ebc, PMID:19578119]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: rfoulger
creation_date: 2011-05-25T03:06:30Z

[Term]
id: GO:0035868
name: alphav-beta3 integrin-HMGB1 complex
namespace: cellular_component
def: "A protein complex that consists of an alphav-beta3 integrin complex bound to high mobility group box 1 protein." [GOC:BHF, GOC:ebc, PMID:20826760]
synonym: "alphav-beta3 integrin-high mobility group box 1 complex" EXACT [GOC:bf]
synonym: "alphaV-beta3 integrin-HMGB1 complex" EXACT [GOC:ebc]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: rfoulger
creation_date: 2011-05-25T03:07:24Z

[Term]
id: GO:0035869
name: ciliary transition zone
namespace: cellular_component
def: "A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition." [GOC:cilia, GOC:kmv, PMID:21422230]
synonym: "cilial transition zone" EXACT []
synonym: "cilium transition zone" EXACT []
is_a: GO:0044441 ! ciliary part
relationship: part_of GO:0031513 ! nonmotile primary cilium
created_by: rfoulger
creation_date: 2011-05-25T03:09:58Z

[Term]
id: GO:0035870
name: dITP diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: dITP + H2O = dIMP + diphosphate." [EC:3.6.1.-, GOC:dgf, PMID:21548881, RHEA:28342]
synonym: "2'-Deoxyinosine-5'-triphosphate pyrophosphohydrolase activity" EXACT [KEGG:R03531]
synonym: "deoxyinosine triphosphate pyrophosphatase activity" EXACT [GOC:bf]
synonym: "dITP pyrophosphatase activity" EXACT [GOC:bf]
xref: EC:3.6.1.-
xref: KEGG:R03531
xref: MetaCyc:RXN0-1602
xref: RHEA:28342
is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity
created_by: rfoulger
creation_date: 2011-05-26T11:32:26Z

[Term]
id: GO:0035871
name: protein K11-linked deubiquitination
namespace: biological_process
def: "A protein deubiquitination process in which a K11-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 11 of the ubiquitin monomers, is removed from a protein." [GOC:sp, PMID:21596315]
synonym: "protein K11-linked deubiquitinylation" EXACT [GOC:bf]
synonym: "protein K11-linked deubiquitylation" EXACT [GOC:bf]
is_a: GO:0016579 ! protein deubiquitination
created_by: rfoulger
creation_date: 2011-05-26T11:44:13Z

[Term]
id: GO:0035872
name: nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
namespace: biological_process
def: "A series of molecular signals generated as a consequence of a nucleotide-binding domain, leucine rich repeat containing receptor (NLR) binding to one of its physiological ligands. NLRs are cytoplasmic receptors defined by their tripartite domain architecture that contains: a variable C-terminus, a middle nucleotide-binding domain, and a LRR domain that is variable in the repeats composition and number. The NLR signaling pathway begins with binding of a ligand to a NLR receptor and ends with regulation of a downstream cellular process." [GOC:sj, PMID:18280719, Reactome:168643]
synonym: "NLR signaling pathway" EXACT [PMID:18280719]
synonym: "NOD-like receptor signaling pathway" RELATED [Wikipedia:NOD-like_receptor]
synonym: "nucleotide-binding domain leucine-rich repeat containing receptor signaling pathway" EXACT [PMID:18280719]
synonym: "nucleotide-binding domain, leucine rich repeat containing receptor signal transduction" EXACT [GOC:bf]
synonym: "nucleotide-binding domain, leucine rich repeat containing receptor signal transduction pathway" EXACT [GOC:bf]
synonym: "nucleotide-binding domain, leucine rich repeat containing receptor signalling pathway" EXACT [GOC:bf]
xref: Reactome:REACT_102126 "Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, Xenopus tropicalis"
xref: Reactome:REACT_105549 "Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, Gallus gallus"
xref: Reactome:REACT_109121 "Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, Mus musculus"
xref: Reactome:REACT_112945 "Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, Drosophila melanogaster"
xref: Reactome:REACT_75913 "Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, Homo sapiens"
xref: Reactome:REACT_85368 "Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, Rattus norvegicus"
xref: Reactome:REACT_91372 "Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, Danio rerio"
xref: Reactome:REACT_95496 "Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, Bos taurus"
xref: Reactome:REACT_95597 "Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, Taeniopygia guttata"
xref: Reactome:REACT_97582 "Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, Canis familiaris"
xref: Reactome:REACT_99740 "Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, Sus scrofa"
is_a: GO:0030522 ! intracellular receptor signaling pathway
created_by: rfoulger
creation_date: 2011-05-26T03:30:36Z

[Term]
id: GO:0035873
name: lactate transmembrane transport
namespace: biological_process
def: "The directed movement of lactate across a membrane by means of some agent such as a transporter or pore. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices." [GOC:mcc, ISBN:0198506732]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "lactate membrane transport" EXACT []
is_a: GO:0015727 ! lactate transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport
created_by: rfoulger
creation_date: 2011-05-31T09:26:59Z

[Term]
id: GO:0035874
name: cellular response to copper ion starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of copper ions." [GOC:vw, PMID:16467469]
synonym: "cellular response to copper starvation" EXACT [GOC:bf]
is_a: GO:0009267 ! cellular response to starvation
created_by: rfoulger
creation_date: 2011-05-31T09:28:47Z

[Term]
id: GO:0035875
name: maintenance of meiotic sister chromatid cohesion, centromeric
namespace: biological_process
def: "The process in which the association between sister chromatids of a replicated chromosome along the length of the centromeric region is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a meiotic cell cycle." [GOC:vw, PMID:1708436]
synonym: "maintenance of centromeric meiotic sister chromatin cohesion" EXACT [GOC:bf]
synonym: "maintenance of meiotic sister chromatin cohesion at centromere" EXACT [GOC:bf]
synonym: "maintenance of sister chromatin cohesion at centromere at meiosis I" EXACT [GOC:bf]
is_a: GO:0034090 ! maintenance of meiotic sister chromatid cohesion
relationship: part_of GO:0051754 ! meiotic sister chromatid cohesion, centromeric
created_by: rfoulger
creation_date: 2011-05-31T09:35:51Z

[Term]
id: GO:0035876
name: maintenance of meiotic sister chromatid cohesion, arms
namespace: biological_process
def: "The process in which the association between sister chromatids of a replicated chromosome along the length of the chromosome arms, is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a meiotic cell cycle." [GOC:vw, PMID:1708436]
synonym: "maintenance of meiotic sister chromatin cohesion along arms" EXACT [GOC:bf]
synonym: "maintenance of sister chromatin cohesion along arms at meiosis I" EXACT [GOC:bf]
is_a: GO:0034090 ! maintenance of meiotic sister chromatid cohesion
relationship: part_of GO:0051760 ! meiotic sister chromatid cohesion, arms
created_by: rfoulger
creation_date: 2011-05-31T09:37:53Z

[Term]
id: GO:0035877
name: death effector domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a DED domain (death effector domain) of a protein, a homotypic protein interaction module composed of a bundle of six alpha-helices that is related in structure to the death domain (DD)." [GOC:ecd, InterPro:IPR001875]
comment: For binding to the death domain, consider instead the term 'death domain binding ; GO:0070513'.
synonym: "DED binding" EXACT [InterPro:IPR001875]
is_a: GO:0019904 ! protein domain specific binding
created_by: rfoulger
creation_date: 2011-05-31T09:40:46Z

[Term]
id: GO:0035878
name: nail development
namespace: biological_process
def: "The process whose specific outcome is the progression of a nail over time, from its formation to the mature structure. A nail is a horn-like envelope covering the outer end of a finger or toe, and consists of the nail plate, the nail matrix and the nail bed below it, and the grooves surrounding it." [GOC:bf, ISBN:0323025781, UBERON:0001705, Wikipedia:Nail_(anatomy)]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0060173 ! limb development
created_by: rfoulger
creation_date: 2011-05-31T02:30:34Z

[Term]
id: GO:0035879
name: plasma membrane lactate transport
namespace: biological_process
def: "The directed movement of lactate across a plasma membrane." [GOC:mcc]
synonym: "lactate plasma membrane transport" EXACT [GOC:bf]
is_a: GO:0035873 ! lactate transmembrane transport
created_by: rfoulger
creation_date: 2011-05-31T02:54:32Z

[Term]
id: GO:0035880
name: embryonic nail plate morphogenesis
namespace: biological_process
def: "The process, occurring in the embryo, by which the anatomical structures of a nail plate are generated and organized. The nail plate is the hard and translucent portion of the nail, composed of keratin, and serves to protect the tips of digits." [GOC:BHF, GOC:vk, ISBN:0323025781, PMID:11369996, UBERON:0008198, Wikipedia:Nail_(anatomy)]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0035878 ! nail development
relationship: part_of GO:0042733 ! embryonic digit morphogenesis
created_by: rfoulger
creation_date: 2011-05-31T02:38:57Z

[Term]
id: GO:0035881
name: amacrine cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an amacrine cell, an interneuron generated in the inner nuclear layer (INL) of the vertebrate retina. Amacrine cells integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer. Amacrine cells lack large axons." [CL:0000561, GOC:bf]
synonym: "amacrine neuron differentiation" EXACT [CL:0000561]
is_a: GO:0030182 ! neuron differentiation
relationship: part_of GO:0003407 ! neural retina development
created_by: rfoulger
creation_date: 2011-06-06T11:32:50Z

[Term]
id: GO:0035882
name: defecation rhythm
namespace: biological_process
def: "The rhythmic process of defecation that consists of an intestinal oscillator which regulates calcium waves. These waves in turn control a stereotypical, three-part pattern of muscle contractions. In some organisms, defecation can recur with a regularity more frequent than every 24 hours. For example, in a well-fed Caenorhabditis elegans, the defecation motor program occurs approximately every 45 seconds, and is temperature- and touch-compensated." [GOC:bf, GOC:kmv, PMID:7479775, PMID:8158250, PMID:9066270]
synonym: "defecation behavior" RELATED [PMID:7479775, PMID:9066270]
synonym: "defecation cycle" EXACT [PMID:8158250]
synonym: "defecation motor program" EXACT [GOC:kmv, PMID:9066270]
synonym: "DMP" EXACT [PMID:9066270]
is_a: GO:0007624 ! ultradian rhythm
relationship: part_of GO:0030421 ! defecation
created_by: rfoulger
creation_date: 2011-06-06T11:36:35Z

[Term]
id: GO:0035883
name: enteroendocrine cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an enteroendocrine cell. Enteroendocrine cells are hormonally active epithelial cells in the gut that constitute the diffuse neuroendocrine system." [CL:0000164, GOC:bf]
is_a: GO:0002067 ! glandular epithelial cell differentiation
created_by: rfoulger
creation_date: 2011-06-06T11:48:51Z

[Term]
id: GO:0035884
name: arabinan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of arabinan, a polysaccharide composed of arabinose residues." [CHEBI:22590, GOC:rs, ISBN:0198506732]
is_a: GO:0000271 ! polysaccharide biosynthetic process
is_a: GO:0031221 ! arabinan metabolic process
created_by: rfoulger
creation_date: 2011-06-08T11:01:14Z

[Term]
id: GO:0035885
name: exochitinase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal 1,4-beta-linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. Typically, exochitinases progressively cleave off two subunits from the reducing or non-reducing ends of the chitin chain." [EC:3.2.1.-, GOC:bf, GOC:kah, GOC:pde, PMID:11468293, PMID:16298970, PMID:21390509]
is_a: GO:0004568 ! chitinase activity
created_by: rfoulger
creation_date: 2011-06-08T11:13:58Z

[Term]
id: GO:0035886
name: vascular smooth muscle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a vascular smooth muscle cell." [GOC:sl, PMID:16151017, PMID:18267954]
synonym: "vascular associated smooth muscle cell differentiation" EXACT [CL:0000359]
synonym: "VSMC differentiation" EXACT [PMID:16151017]
is_a: GO:0051145 ! smooth muscle cell differentiation
relationship: part_of GO:0001944 ! vasculature development
created_by: rfoulger
creation_date: 2011-06-08T11:23:52Z

[Term]
id: GO:0035887
name: aortic smooth muscle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell surrounding the aorta." [GOC:sl]
is_a: GO:0035886 ! vascular smooth muscle cell differentiation
created_by: rfoulger
creation_date: 2011-06-08T11:34:26Z

[Term]
id: GO:0035888
name: isoguanine deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: isoguanine + H2O = xanthine + NH3." [EC:3.5.4.-, GOC:imk, PMID:21604715]
synonym: "2-hydroxyadenine deaminase activity" EXACT [PMID:14709079, PMID:8841637]
synonym: "2-oxoadenine deaminase activity" EXACT [PMID:14709079]
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity
created_by: rfoulger
creation_date: 2011-06-14T02:15:53Z

[Term]
id: GO:0035889
name: otolith tethering
namespace: biological_process
def: "The attachment of a developing otolith to the kinocilia of tether cells in the inner ear." [GOC:dgh, PMID:14499652]
is_a: GO:0044707 ! single-multicellular organism process
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0048840 ! otolith development
created_by: rfoulger
creation_date: 2011-06-14T02:28:14Z

[Term]
id: GO:0035890
name: exit from host
namespace: biological_process
def: "The directed movement of an organism out of the body, tissues or cells of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:bf]
synonym: "ejection from host" RELATED [GOC:bf]
is_a: GO:0052126 ! movement in host environment
created_by: rfoulger
creation_date: 2011-06-15T02:08:03Z

[Term]
id: GO:0035891
name: exit from host cell
namespace: biological_process
def: "The directed movement of an organism out of a cell of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:bf, GOC:rs, PMID:19325115]
synonym: "ejection from host cell" RELATED [PMID:19325115]
synonym: "host cell exit" EXACT [PMID:19325115]
is_a: GO:0035890 ! exit from host
created_by: rfoulger
creation_date: 2011-06-15T02:09:28Z

[Term]
id: GO:0035892
name: modulation of platelet aggregation in other organism
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of platelet aggregation in another organism. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules." [GOC:bf, GOC:fj, PMID:15922770]
synonym: "modulation by organism of platelet aggregation in other organism" EXACT [GOC:bf]
synonym: "regulation of platelet aggregation in other organism" RELATED [GOC:bf]
is_a: GO:0035806 ! modulation of blood coagulation in other organism
is_a: GO:0044364 ! disruption of cells of other organism
is_a: GO:0090330 ! regulation of platelet aggregation
created_by: rfoulger
creation_date: 2011-06-15T02:21:10Z

[Term]
id: GO:0035893
name: negative regulation of platelet aggregation in other organism
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of platelet aggregation in a second organism." [GOC:bf, GOC:fj, PMID:15922770]
synonym: "down-regulation of platelet aggregation in other organism" EXACT [GOC:bf]
synonym: "downregulation of platelet aggregation in other organism" EXACT [GOC:bf]
synonym: "inhibition of platelet aggregation in other organism" EXACT [GOC:bf]
synonym: "suppression of platelet aggregation in other organism" EXACT [GOC:bf]
is_a: GO:0035892 ! modulation of platelet aggregation in other organism
is_a: GO:0035899 ! negative regulation of blood coagulation in other organism
is_a: GO:0090331 ! negative regulation of platelet aggregation
created_by: rfoulger
creation_date: 2011-06-15T02:24:43Z

[Term]
id: GO:0035894
name: positive regulation of platelet aggregation in other organism
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of platelet aggregation in another organism." [GOC:bf, GOC:fj, PMID:11453648, PMID:18804547]
synonym: "up-regulation of platelet aggregation in other organism" RELATED [GOC:bf]
synonym: "upregulation of platelet aggregation in other organism" EXACT [GOC:bf]
is_a: GO:0035807 ! positive regulation of blood coagulation in other organism
is_a: GO:0035892 ! modulation of platelet aggregation in other organism
is_a: GO:1901731 ! positive regulation of platelet aggregation
created_by: rfoulger
creation_date: 2011-06-15T02:28:46Z

[Term]
id: GO:0035895
name: modulation of mast cell degranulation in other organism
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of blood mast cell degranulation in another organism. Mast cell degranulation is the regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell." [GOC:bf, GOC:fj, PMID:21549739]
synonym: "regulation of mast cell degranulation in other organism" EXACT [GOC:bf]
is_a: GO:0035821 ! modification of morphology or physiology of other organism
is_a: GO:0043304 ! regulation of mast cell degranulation
created_by: rfoulger
creation_date: 2011-06-15T02:46:50Z

[Term]
id: GO:0035896
name: positive regulation of mast cell degranulation in other organism
namespace: biological_process
def: "Any process in which an organism increases the frequency, rate or extent of blood mast cell degranulation in another organism." [GOC:bf, GOC:fj]
synonym: "up-regulation of mast cell degranulation in other organism" RELATED [GOC:bf]
synonym: "upregulation of mast cell degranulation in other organism" EXACT [GOC:bf]
is_a: GO:0035895 ! modulation of mast cell degranulation in other organism
is_a: GO:0043306 ! positive regulation of mast cell degranulation
created_by: rfoulger
creation_date: 2011-06-15T02:49:03Z

[Term]
id: GO:0035897
name: proteolysis in other organism
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the hydrolysis of proteins in another organism by cleavage of their peptide bonds." [GOC:bf, GOC:fj, PMID:15922779]
is_a: GO:0006508 ! proteolysis
is_a: GO:0044033 ! multi-organism metabolic process
created_by: rfoulger
creation_date: 2011-06-15T03:00:27Z

[Term]
id: GO:0035898
name: parathyroid hormone secretion
namespace: biological_process
def: "The regulated release of parathyroid hormone into the circulatory system." [GOC:cjm, PMID:12171519, PMID:21164021, PR:000013429]
synonym: "parathormone secretion" EXACT [PR:000013429]
synonym: "parathyrin secretion" EXACT [PR:000013429]
synonym: "PTH secretion" EXACT [PMID:12171519, PR:000013429]
is_a: GO:0060986 ! endocrine hormone secretion
created_by: rfoulger
creation_date: 2011-06-22T09:28:54Z

[Term]
id: GO:0035899
name: negative regulation of blood coagulation in other organism
namespace: biological_process
def: "Any process in which an organism stops, prevents or reduces the frequency, rate or extent of blood coagulation in another organism. Blood coagulation is the sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot." [GOC:fj]
synonym: "down-regulation of blood coagulation in other organism" EXACT [GOC:bf]
synonym: "downregulation of blood coagulation in other organism" EXACT [GOC:bf]
synonym: "inhibition of blood coagulation in other organism" NARROW [GOC:bf]
synonym: "negative regulation of blood clotting in other organism" EXACT [GOC:bf]
synonym: "suppression of blood coagulation in other organism" EXACT [GOC:bf]
is_a: GO:0030195 ! negative regulation of blood coagulation
is_a: GO:0035806 ! modulation of blood coagulation in other organism
created_by: rfoulger
creation_date: 2011-06-22T09:17:54Z

[Term]
id: GO:0035900
name: response to isolation stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lack of contact with other members of the same species." [GOC:bf, PMID:20203532]
synonym: "response to social isolation" EXACT [PMID:20203532]
is_a: GO:0006950 ! response to stress
created_by: rfoulger
creation_date: 2011-06-22T09:39:57Z

[Term]
id: GO:0035901
name: cellular response to isolation stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lack of contact with other members of the same species." [GOC:bf, PMID:20203532]
synonym: "cellular response to social isolation" EXACT [PMID:20203532]
is_a: GO:0033554 ! cellular response to stress
is_a: GO:0035900 ! response to isolation stress
created_by: rfoulger
creation_date: 2011-06-22T09:43:34Z

[Term]
id: GO:0035902
name: response to immobilization stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of being rendered immobile." [GOC:bf, PMID:17683801, PMID:19893991]
synonym: "response to immobilisation stress" EXACT [GOC:bf]
synonym: "response to restraint stress" RELATED [GOC:sl]
is_a: GO:0006950 ! response to stress
created_by: rfoulger
creation_date: 2011-06-22T09:45:50Z

[Term]
id: GO:0035903
name: cellular response to immobilization stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of being rendered immobile." [GOC:bf, PMID:17683801, PMID:19893991]
synonym: "cellular response to immobilisation stress" EXACT [GOC:bf]
synonym: "cellular response to restraint stress" RELATED [GOC:sl]
is_a: GO:0033554 ! cellular response to stress
is_a: GO:0035902 ! response to immobilization stress
created_by: rfoulger
creation_date: 2011-06-22T09:47:44Z

[Term]
id: GO:0035904
name: aorta development
namespace: biological_process
def: "The progression of the aorta over time, from its initial formation to the mature structure. An aorta is an artery that carries blood from the heart to other parts of the body." [GOC:bf, GOC:dgh, MA:0000062, UBERON:0000947, Wikipedia:Aorta]
is_a: GO:0060840 ! artery development
created_by: rfoulger
creation_date: 2011-06-24T11:00:07Z

[Term]
id: GO:0035905
name: ascending aorta development
namespace: biological_process
def: "The progression of the ascending aorta over time, from its initial formation to the mature structure. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once." [GOC:bf, GOC:dgh, MA:0002570, UBERON:0001496, Wikipedia:Ascending_aorta]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0035904 ! aorta development
created_by: rfoulger
creation_date: 2011-06-24T11:02:01Z

[Term]
id: GO:0035906
name: descending aorta development
namespace: biological_process
def: "The progression of the descending aorta over time, from its initial formation to the mature structure. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once." [GOC:bf, GOC:dgh, MA:0002571, UBERON:0001514, Wikipedia:Descending_aorta]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0035904 ! aorta development
created_by: rfoulger
creation_date: 2011-06-24T11:05:22Z

[Term]
id: GO:0035907
name: dorsal aorta development
namespace: biological_process
def: "The progression of the dorsal aorta over time, from its initial formation to the mature structure. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once." [GOC:bf, GOC:dgh, UBERON:0005805, Wikipedia:Aorta, ZFA:0000014]
is_a: GO:0035904 ! aorta development
created_by: rfoulger
creation_date: 2011-06-24T11:07:01Z

[Term]
id: GO:0035908
name: ventral aorta development
namespace: biological_process
def: "The progression of the ventral aorta over time, from its initial formation to the mature structure. The ventral aorta is a blood vessel in a single-pass circulatory system that carries de-oxygenated blood from the heart to the gills. In a single-pass circulatory system blood passes once through the heart to supply the body once." [GOC:bf, GOC:dgh, UBERON:0003085, Wikipedia:Aorta, ZFA:0000604]
is_a: GO:0035904 ! aorta development
created_by: rfoulger
creation_date: 2011-06-24T11:08:49Z

[Term]
id: GO:0035909
name: aorta morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of an aorta are generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body." [GOC:bf, GOC:dgh, MA:0000062, UBERON:0000947, Wikipedia:Aorta]
is_a: GO:0048844 ! artery morphogenesis
relationship: part_of GO:0035904 ! aorta development
created_by: rfoulger
creation_date: 2011-06-24T11:11:11Z

[Term]
id: GO:0035910
name: ascending aorta morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the ascending aorta are generated and organized. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once." [GOC:bf, GOC:dgh, MA:0002570, UBERON:0001496, Wikipedia:Ascending_aorta]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0035905 ! ascending aorta development
relationship: part_of GO:0035909 ! aorta morphogenesis
created_by: rfoulger
creation_date: 2011-06-24T11:14:52Z

[Term]
id: GO:0035911
name: descending aorta morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the descending aorta are generated and organized. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once." [GOC:bf, GOC:dgh, MA:0002571, UBERON:0001514, Wikipedia:Descending_aorta]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0035906 ! descending aorta development
relationship: part_of GO:0035909 ! aorta morphogenesis
created_by: rfoulger
creation_date: 2011-06-24T11:19:24Z

[Term]
id: GO:0035912
name: dorsal aorta morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the dorsal aorta are generated and organized. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once." [GOC:bf, GOC:dgh, UBERON:0005805, Wikipedia:Aorta, ZFA:0000014]
is_a: GO:0035909 ! aorta morphogenesis
relationship: part_of GO:0035907 ! dorsal aorta development
created_by: rfoulger
creation_date: 2011-06-24T11:22:14Z

[Term]
id: GO:0035913
name: ventral aorta morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the ventral aorta are generated and organized. The ventral aorta is a blood vessel in a single-pass circulatory system that carries de-oxygenated blood from the heart to the gills. In a single-pass circulatory system blood passes once through the heart to supply the body once." [GOC:bf, GOC:dgh, UBERON:0003085, Wikipedia:Aorta, ZFA:0000604]
is_a: GO:0035909 ! aorta morphogenesis
relationship: part_of GO:0035908 ! ventral aorta development
created_by: rfoulger
creation_date: 2011-06-24T11:24:36Z

[Term]
id: GO:0035914
name: skeletal muscle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle." [CL:0000188, GOC:BHF, GOC:vk]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0007519 ! skeletal muscle tissue development
created_by: rfoulger
creation_date: 2011-06-24T02:36:19Z

[Term]
id: GO:0035915
name: pore formation in membrane of other organism
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components by an organism to form a pore complex in a membrane of another organism." [GOC:bf, GOC:fj, PMID:21549739]
synonym: "pore biosynthesis in other organism" EXACT [GOC:bf]
synonym: "pore complex assembly in other organism" EXACT []
synonym: "pore complex biogenesis in other organism" EXACT [GOC:bf]
synonym: "pore formation in other organism" EXACT [GOC:bf]
synonym: "pore-forming toxin activity" RELATED [GOC:bf]
is_a: GO:0016043 ! cellular component organization
is_a: GO:0044764 ! multi-organism cellular process
is_a: GO:0051673 ! membrane disruption in other organism
created_by: rfoulger
creation_date: 2011-07-01T11:45:01Z

[Term]
id: GO:0035916
name: modulation of calcium channel activity in other organism
namespace: biological_process
def: "Any process in which an organism effects a change in the frequency, rate or extent of the activity of a calcium channel in another organism." [GOC:bf, GOC:fj, PMID:20920515]
is_a: GO:0044561 ! modulation of ion channel activity in other organism
created_by: rfoulger
creation_date: 2011-07-01T11:51:38Z

[Term]
id: GO:0035917
name: negative regulation of calcium channel activity in other organism
namespace: biological_process
def: "Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a calcium channel in another organism." [GOC:bf, GOC:fj, PMID:20920515]
synonym: "down-regulation of calcium channel activity in other organism" EXACT [GOC:bf]
synonym: "downregulation of calcium channel activity in other organism" EXACT [GOC:bf]
synonym: "inhibition of calcium channel activity in other organism" NARROW [GOC:bf]
is_a: GO:0035916 ! modulation of calcium channel activity in other organism
is_a: GO:0052204 ! negative regulation of molecular function in other organism involved in symbiotic interaction
is_a: GO:2001258 ! negative regulation of cation channel activity
created_by: rfoulger
creation_date: 2011-07-01T11:52:55Z

[Term]
id: GO:0035918
name: negative regulation of voltage-gated calcium channel activity in other organism
namespace: biological_process
def: "Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a voltage-gated calcium channel in another organism. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:bf, GOC:fj, ISBN:0815340729, PMID:20920515]
synonym: "down-regulation of voltage-gated calcium channel activity in other organism" EXACT [GOC:bf]
synonym: "downregulation of voltage-gated calcium channel activity in other organism" EXACT [GOC:bf]
synonym: "inhibition of voltage-gated calcium channel activity in other organism" NARROW [GOC:bf]
synonym: "negative regulation of voltage gated calcium channel activity in other organism" EXACT [GOC:bf]
synonym: "negative regulation of voltage-dependent calcium channel activity in other organism" EXACT [GOC:bf]
synonym: "negative regulation of voltage-sensitive calcium channel activity in other organism" EXACT [GOC:bf]
is_a: GO:0035917 ! negative regulation of calcium channel activity in other organism
created_by: rfoulger
creation_date: 2011-07-01T11:54:43Z

[Term]
id: GO:0035919
name: negative regulation of low voltage-gated calcium channel activity in other organism
namespace: biological_process
def: "Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a low voltage-gated calcium channel in another organism. A low voltage-gated channel is a channel whose open state is dependent on low voltage across the membrane in which it is embedded." [GOC:bf, GOC:fj, ISBN:0815340729, PMID:20920515]
synonym: "down-regulation of low voltage-gated calcium channel activity in other organism" EXACT [GOC:bf]
synonym: "downregulation of low voltage-gated calcium channel activity in other organism" EXACT [GOC:bf]
synonym: "inhibition of low voltage-gated calcium channel activity in other organism" NARROW [GOC:bf]
synonym: "negative regulation of low voltage gated calcium channel activity in other organism" EXACT [GOC:bf]
synonym: "negative regulation of low voltage-dependent calcium channel activity in other organism" EXACT [GOC:bf]
is_a: GO:0035918 ! negative regulation of voltage-gated calcium channel activity in other organism
created_by: rfoulger
creation_date: 2011-07-01T11:56:21Z

[Term]
id: GO:0035920
name: negative regulation of high voltage-gated calcium channel activity in other organism
namespace: biological_process
def: "Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a high voltage-gated calcium channel in another organism. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded." [GOC:bf, GOC:fj, ISBN:0815340729, PMID:20920515]
synonym: "down-regulation of high voltage-gated calcium channel activity in other organism" EXACT [GOC:bf]
synonym: "downregulation of high voltage-gated calcium channel activity in other organism" EXACT [GOC:bf]
synonym: "inhibition of high voltage-gated calcium channel activity in other organism" NARROW [GOC:bf]
synonym: "negative regulation of high voltage gated calcium channel activity in other organism" EXACT [GOC:bf]
synonym: "negative regulation of high voltage-dependent calcium channel activity in other organism" EXACT [GOC:bf]
is_a: GO:0035918 ! negative regulation of voltage-gated calcium channel activity in other organism
created_by: rfoulger
creation_date: 2011-07-01T12:00:23Z

[Term]
id: GO:0035921
name: desmosome disassembly
namespace: biological_process
def: "The controlled breakdown of a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm." [GOC:BHF, GOC:vk, ISBN:0198506732, PMID:9182671]
synonym: "desmosome dissociation" EXACT [PMID:9182671]
is_a: GO:0002934 ! desmosome organization
is_a: GO:0022411 ! cellular component disassembly
created_by: rfoulger
creation_date: 2011-07-05T01:33:25Z

[Term]
id: GO:0035922
name: foramen ovale closure
namespace: biological_process
def: "The morphogenetic process in which the foramen ovale closes after birth, to prevent blood flow between the right and left atria. In the fetal heart, the foramen ovale allows blood to enter the left atrium from the right atrium. Closure of the foramen ovale after birth stops this blood flow." [GOC:BHF, GOC:vk, PMID:19762328, UBERON:0004754, Wikipedia:Foramen_ovale_(heart)]
synonym: "foramen ovale of heart closure" EXACT [UBERON:0004754]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0060411 ! cardiac septum morphogenesis
created_by: rfoulger
creation_date: 2011-07-05T01:39:54Z

[Term]
id: GO:0035923
name: flurbiprofen binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with flurbiprofen." [CHEBI:5130, GOC:BHF, GOC:rl]
synonym: "2-(2-fluoro-[1,1'-biphenyl-4-yl])propanoic acid binding" EXACT [CHEBI:5130]
is_a: GO:0097159 ! organic cyclic compound binding
created_by: rfoulger
creation_date: 2011-07-15T03:53:53Z

[Term]
id: GO:0035924
name: cellular response to vascular endothelial growth factor stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vascular endothelial growth factor stimulus." [GOC:BHF, GOC:rl, PMID:18440775]
synonym: "cellular response to vascular endothelial growth factor" EXACT [GOC:rl]
synonym: "cellular response to VEGF" EXACT [GOC:rl]
synonym: "cellular response to VEGFA" NARROW [GOC:rl]
synonym: "cellular response to VEGFB" NARROW [GOC:rl]
is_a: GO:0071363 ! cellular response to growth factor stimulus
created_by: rfoulger
creation_date: 2011-07-15T04:03:29Z

[Term]
id: GO:0035925
name: mRNA 3'-UTR AU-rich region binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule." [GOC:vw]
synonym: "mRNA 3'-UTR adenylate/uridylate-rich element binding" EXACT [PMID:8578590]
is_a: GO:0003730 ! mRNA 3'-UTR binding
is_a: GO:0017091 ! AU-rich element binding
created_by: rfoulger
creation_date: 2011-07-19T09:30:18Z

[Term]
id: GO:0035926
name: chemokine (C-C motif) ligand 2 secretion
namespace: biological_process
def: "The regulated release of chemokine (C-C motif) ligand 2 (CCL2) from a cell." [PMID:21501162]
synonym: "CCL2 secretion" EXACT [GOC:bf]
is_a: GO:0090195 ! chemokine secretion
relationship: part_of GO:0072567 ! chemokine (C-X-C motif) ligand 2 production
created_by: rfoulger
creation_date: 2011-07-19T09:33:54Z

[Term]
id: GO:0035927
name: RNA import into mitochondrion
namespace: biological_process
def: "The directed movement of RNA from the cytoplasm into a mitochondrion." [GOC:ans, PMID:20691904]
synonym: "cytoplasmic RNA import into mitochondrion" NARROW [GOC:ans]
synonym: "nuclear-encoded RNA import into mitochondrion" NARROW [GOC:bf]
is_a: GO:0006839 ! mitochondrial transport
is_a: GO:0050658 ! RNA transport
created_by: rfoulger
creation_date: 2011-07-19T09:39:37Z

[Term]
id: GO:0035928
name: rRNA import into mitochondrion
namespace: biological_process
def: "The directed movement of rRNA, ribosomal ribonucleic acid, from the cytoplasm into a mitochondrion." [GOC:ans, PMID:20691904]
synonym: "cytoplasmic rRNA import into mitochondrion" NARROW [GOC:ans]
synonym: "nuclear-encoded rRNA import into mitochondrion" NARROW [GOC:bf]
is_a: GO:0035927 ! RNA import into mitochondrion
is_a: GO:0051029 ! rRNA transport
created_by: rfoulger
creation_date: 2011-07-19T09:41:42Z

[Term]
id: GO:0035929
name: steroid hormone secretion
namespace: biological_process
def: "The regulated release of any steroid that acts as a hormone into the circulatory system." [CHEBI:26764, GOC:sl]
is_a: GO:0006869 ! lipid transport
is_a: GO:0060986 ! endocrine hormone secretion
created_by: rfoulger
creation_date: 2011-07-20T01:01:00Z

[Term]
id: GO:0035930
name: corticosteroid hormone secretion
namespace: biological_process
def: "The regulated release of any corticosteroid hormone into the circulatory system." [CHEBI:3669, GOC:sl]
synonym: "corticosteroid secretion" BROAD [GOC:bf]
is_a: GO:0035929 ! steroid hormone secretion
created_by: rfoulger
creation_date: 2011-07-20T01:03:22Z

[Term]
id: GO:0035931
name: mineralocorticoid secretion
namespace: biological_process
def: "The regulated release of any mineralocorticoid into the circulatory system. Mineralocorticoids are a class of steroid hormones that regulate water and electrolyte metabolism." [CHEBI:25354, GOC:sl]
is_a: GO:0035930 ! corticosteroid hormone secretion
created_by: rfoulger
creation_date: 2011-07-20T01:04:59Z

[Term]
id: GO:0035932
name: aldosterone secretion
namespace: biological_process
def: "The regulated release of aldosterone into the circulatory system. Aldosterone is a pregnane-based steroid hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney." [CHEBI:27584, GOC:sl]
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0035931 ! mineralocorticoid secretion
created_by: rfoulger
creation_date: 2011-07-20T01:06:24Z

[Term]
id: GO:0035933
name: glucocorticoid secretion
namespace: biological_process
def: "The regulated release of any glucocorticoid hormone into the circulatory system. Glucocorticoids are a class of steroid hormones that regulate a variety of physiological processes, in particular control of the concentration of glucose in blood." [CHEBI:24261, GOC:sl]
is_a: GO:0035930 ! corticosteroid hormone secretion
created_by: rfoulger
creation_date: 2011-07-20T01:08:37Z

[Term]
id: GO:0035934
name: corticosterone secretion
namespace: biological_process
def: "The regulated release of corticosterone into the circulatory system. Corticosterone is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands." [CHEBI:16827, GOC:sl]
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0035933 ! glucocorticoid secretion
created_by: rfoulger
creation_date: 2011-07-20T01:09:31Z

[Term]
id: GO:0035935
name: androgen secretion
namespace: biological_process
def: "The regulated release of an androgen into the circulatory system. Androgens are steroid hormones that stimulate or control the development and maintenance of masculine characteristics in vertebrates." [CHEBI:50113, GOC:sl]
is_a: GO:0035929 ! steroid hormone secretion
created_by: rfoulger
creation_date: 2011-07-20T01:11:31Z

[Term]
id: GO:0035936
name: testosterone secretion
namespace: biological_process
def: "The regulated release of testosterone into the circulatory system. Testosterone is an androgen having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5." [CHEBI:17347, GOC:sl, PMID:12606499]
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0035935 ! androgen secretion
created_by: rfoulger
creation_date: 2011-07-20T01:13:13Z

[Term]
id: GO:0035937
name: estrogen secretion
namespace: biological_process
def: "The regulated release of estrogen into the circulatory system. Estrogen is a steroid hormone that stimulates or controls the development and maintenance of female sex characteristics in mammals." [CHEBI:50114, GOC:sl]
synonym: "oestrogen secretion" RELATED [CHEBI:50114]
is_a: GO:0035929 ! steroid hormone secretion
created_by: rfoulger
creation_date: 2011-07-20T01:14:44Z

[Term]
id: GO:0035938
name: estradiol secretion
namespace: biological_process
def: "The regulated release of estradiol into the circulatory system." [CHEBI:23965, GOC:sl, PMID:21632818]
synonym: "oestradiol secretion" EXACT [CHEBI:23965]
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0035937 ! estrogen secretion
created_by: rfoulger
creation_date: 2011-07-20T01:16:45Z

[Term]
id: GO:0035939
name: microsatellite binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a microsatellite, a repeat_region in DNA containing repeat units (2 to 4 base pairs) that is repeated multiple times in tandem." [GOC:yaf, PMID:21290414, SO:0000289]
synonym: "microsatellite DNA binding" EXACT [GOC:bf]
synonym: "variable number tandem repeat binding" EXACT [PMID:21290414]
synonym: "VNTR binding" EXACT [SO:0000289]
is_a: GO:0003696 ! satellite DNA binding
created_by: rfoulger
creation_date: 2011-07-20T01:26:26Z

[Term]
id: GO:0035940
name: negative regulation of peptidase activity in other organism
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of peptidase activity, the catalysis of the hydrolysis of peptide bonds in a protein, in a second organism." [GOC:klp, PMID:10595640]
synonym: "down regulation of peptidase activity in other organism" EXACT [GOC:bf]
synonym: "down-regulation of protease activity in other organism" NARROW [GOC:bf]
synonym: "downregulation of peptidase activity in other organism" EXACT [GOC:bf]
synonym: "inhibition of protease activity in other organism" NARROW [GOC:bf]
synonym: "negative regulation of protease activity in other organism" NARROW [GOC:bf]
is_a: GO:0010466 ! negative regulation of peptidase activity
is_a: GO:0044362 ! negative regulation of molecular function in other organism
created_by: rfoulger
creation_date: 2011-07-22T02:59:40Z

[Term]
id: GO:0035941
name: androstenedione secretion
namespace: biological_process
def: "The regulated release of androstenedione (androst-4-ene-3,17-dione) into the circulatory system." [CHEBI:16422, GOC:sl]
synonym: "androst-4-ene-3,17-dione secretion" EXACT [CHEBI:16422]
is_a: GO:0035935 ! androgen secretion
created_by: rfoulger
creation_date: 2011-07-25T02:11:47Z

[Term]
id: GO:0035942
name: dehydroepiandrosterone secretion
namespace: biological_process
def: "The regulated release of dehydroepiandrosterone (3beta-hydroxyandrost-5-en-17-one) into the circulatory system." [CHEBI:28689, GOC:sl]
synonym: "3beta-hydroxyandrost-5-en-17-one secretion" EXACT [CHEBI:28689]
synonym: "dehydroisoandrosterone secretion" EXACT [CHEBI:28689]
synonym: "DHEA secretion" EXACT [CHEBI:28689]
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0035935 ! androgen secretion
created_by: rfoulger
creation_date: 2011-07-25T02:13:54Z

[Term]
id: GO:0035943
name: estrone secretion
namespace: biological_process
def: "The regulated release of estrone into the circulatory system." [CHEBI:17263, GOC:sl, PMID:8395854]
synonym: "3-hydroxy-1,3,5(10)-estratrien-17-one secretion" EXACT [CHEBI:17263]
synonym: "folliculin secretion" EXACT [CHEBI:17263]
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0035937 ! estrogen secretion
created_by: rfoulger
creation_date: 2011-07-25T02:18:40Z

[Term]
id: GO:0035944
name: perforin production
namespace: biological_process
def: "The appearance of a perforin protein due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv, PR:000003466]
is_a: GO:0002440 ! production of molecular mediator of immune response
created_by: rfoulger
creation_date: 2011-07-27T11:44:21Z

[Term]
id: GO:0035945
name: mitochondrial ncRNA surveillance
namespace: biological_process
def: "The set of processes involved in identifying and degrading defective or aberrant non-coding RNA transcripts (ncRNAs) within the mitochondrion." [GOC:ans, PMID:19864255]
synonym: "mitochondrial aberrant ncRNA catabolic process" EXACT [GOC:dgf, GOC:krc]
synonym: "mitochondrial ncRNA quality control" EXACT [GOC:dgf, GOC:krc]
synonym: "mitochondrial non-coding RNA surveillance" EXACT [GOC:bf]
is_a: GO:2000827 ! mitochondrial RNA surveillance
created_by: rfoulger
creation_date: 2011-07-28T10:34:59Z

[Term]
id: GO:0035946
name: mitochondrial mRNA surveillance
namespace: biological_process
def: "The set of processes involved in identifying and degrading messenger RNA (mRNA) within the mitochondrion." [GOC:ans, PMID:19864255]
synonym: "mitochondrial aberrant RNA catabolic process" EXACT [GOC:dgf, GOC:krc]
synonym: "mitochondrial messenger RNA surveillance" EXACT [GOC:bf]
synonym: "mitochondrial mRNA quality control" EXACT [GOC:dgf, GOC:krc]
is_a: GO:2000827 ! mitochondrial RNA surveillance
created_by: rfoulger
creation_date: 2011-07-28T10:37:07Z

[Term]
id: GO:0035947
name: regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gluconeogenesis, by regulation of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:11024040, PMID:17875938, PMID:19686338]
synonym: "regulation of gluconeogenesis by regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "regulation of glucose biosynthesis by regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "regulation of glucose biosynthesis by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "regulation of glucose biosynthetic process by regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "regulation of glucose biosynthetic process by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
is_a: GO:0006111 ! regulation of gluconeogenesis
is_a: GO:0072364 ! regulation of cellular ketone metabolic process by regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
intersection_of: regulates GO:0006094 ! gluconeogenesis
relationship: regulates GO:0006094 ! gluconeogenesis
created_by: rfoulger

[Term]
id: GO:0035948
name: positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of gluconeogenesis by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:17875938]
synonym: "regulation of gluconeogenesis by activation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "regulation of gluconeogenesis by positive regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "regulation of gluconeogenesis by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "regulation of gluconeogenesis by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "regulation of gluconeogenesis by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "regulation of gluconeogenesis by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "regulation of glucose biosynthesis by positive regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "regulation of glucose biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "regulation of glucose biosynthesis by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "regulation of glucose biosynthesis by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "regulation of glucose biosynthesis by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "regulation of glucose biosynthetic process by positive regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "regulation of glucose biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol]
synonym: "regulation of glucose biosynthetic process by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "regulation of glucose biosynthetic process by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "regulation of glucose biosynthetic process by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
is_a: GO:0035947 ! regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter
is_a: GO:0045722 ! positive regulation of gluconeogenesis
is_a: GO:0072366 ! regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
intersection_of: positively_regulates GO:0006094 ! gluconeogenesis
relationship: positively_regulates GO:0006094 ! gluconeogenesis
created_by: rfoulger

[Term]
id: GO:0035949
name: positive regulation of gluconeogenesis by negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of gluconeogenesis by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:17875938]
synonym: "positive regulation of gluconeogenesis by down regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of gluconeogenesis by down-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of gluconeogenesis by downregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of gluconeogenesis by inhibition of transcription from RNA polymerase II promoter" NARROW [GOC:obol]
synonym: "positive regulation of gluconeogenesis by negative regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "positive regulation of glucose biosynthesis by down regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of glucose biosynthesis by down-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of glucose biosynthesis by downregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of glucose biosynthesis by negative regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "positive regulation of glucose biosynthesis by negative regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol]
synonym: "positive regulation of glucose biosynthetic process by down regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of glucose biosynthetic process by down-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of glucose biosynthetic process by downregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of glucose biosynthetic process by negative regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "positive regulation of glucose biosynthetic process by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
is_a: GO:0035947 ! regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter
is_a: GO:0045722 ! positive regulation of gluconeogenesis
is_a: GO:0072365 ! regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0045722 ! positive regulation of gluconeogenesis
intersection_of: negatively_regulates GO:0006366 ! transcription from RNA polymerase II promoter
relationship: negatively_regulates GO:0006366 ! transcription from RNA polymerase II promoter
created_by: rfoulger

[Term]
id: GO:0035950
name: regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of oligopeptide transport, by regulation of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:17005992]
synonym: "regulation of oligopeptide transport by regulation of transcription from Pol II promoter" EXACT [GOC:obol]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0090088 ! regulation of oligopeptide transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: regulates GO:0006857 ! oligopeptide transport
relationship: regulates GO:0006366 ! transcription from RNA polymerase II promoter
relationship: regulates GO:0006857 ! oligopeptide transport
created_by: rfoulger

[Term]
id: GO:0035951
name: positive regulation of oligopeptide transport by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of oligopeptide transport by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf]
synonym: "positive regulation of oligopeptide transport by activation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of oligopeptide transport by positive regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "positive regulation of oligopeptide transport by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of oligopeptide transport by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of oligopeptide transport by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of oligopeptide transport by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
is_a: GO:0035950 ! regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
is_a: GO:2000878 ! positive regulation of oligopeptide transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: positively_regulates GO:0006857 ! oligopeptide transport
relationship: positively_regulates GO:0006366 ! transcription from RNA polymerase II promoter
relationship: positively_regulates GO:0006857 ! oligopeptide transport
created_by: rfoulger

[Term]
id: GO:0035952
name: negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of oligopeptide transport by stopping, preventing or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:17005992]
synonym: "negative regulation of oligopeptide transport by down regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "negative regulation of oligopeptide transport by down-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "negative regulation of oligopeptide transport by downregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "negative regulation of oligopeptide transport by inhibition of transcription from RNA polymerase II promoter" NARROW [GOC:obol]
synonym: "negative regulation of oligopeptide transport by negative regulation of transcription from Pol II promoter" EXACT [GOC:obol]
is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
is_a: GO:0035950 ! regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter
is_a: GO:2000877 ! negative regulation of oligopeptide transport
intersection_of: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
intersection_of: negatively_regulates GO:0006857 ! oligopeptide transport
relationship: negatively_regulates GO:0006857 ! oligopeptide transport
created_by: rfoulger

[Term]
id: GO:0035953
name: regulation of dipeptide transport by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dipeptide transport, by regulation of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:17005992]
synonym: "regulation of dipeptide transport by regulation of transcription from Pol II promoter" EXACT [GOC:obol]
is_a: GO:0035950 ! regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter
is_a: GO:0090089 ! regulation of dipeptide transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: regulates GO:0042938 ! dipeptide transport
relationship: regulates GO:0006366 ! transcription from RNA polymerase II promoter
relationship: regulates GO:0042938 ! dipeptide transport
created_by: rfoulger

[Term]
id: GO:0035954
name: positive regulation of dipeptide transport by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of dipeptide transport by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf]
synonym: "positive regulation of dipeptide transport by activation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of dipeptide transport by positive regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "positive regulation of dipeptide transport by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of dipeptide transport by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of dipeptide transport by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of dipeptide transport by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
is_a: GO:0035951 ! positive regulation of oligopeptide transport by positive regulation of transcription from RNA polymerase II promoter
is_a: GO:0035953 ! regulation of dipeptide transport by regulation of transcription from RNA polymerase II promoter
is_a: GO:2000880 ! positive regulation of dipeptide transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: positively_regulates GO:0042938 ! dipeptide transport
relationship: positively_regulates GO:0006366 ! transcription from RNA polymerase II promoter
relationship: positively_regulates GO:0042938 ! dipeptide transport
created_by: rfoulger

[Term]
id: GO:0035955
name: negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of dipeptide transport by stopping, preventing or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:10850718, PMID:17005992, PMID:9427760]
synonym: "negative regulation of dipeptide transport by down regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "negative regulation of dipeptide transport by down-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "negative regulation of dipeptide transport by downregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "negative regulation of dipeptide transport by inhibition of transcription from RNA polymerase II promoter" NARROW [GOC:obol]
synonym: "negative regulation of dipeptide transport by negative regulation of transcription from Pol II promoter" EXACT [GOC:obol]
is_a: GO:0035952 ! negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter
is_a: GO:0035953 ! regulation of dipeptide transport by regulation of transcription from RNA polymerase II promoter
is_a: GO:2000879 ! negative regulation of dipeptide transport
intersection_of: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
intersection_of: negatively_regulates GO:0042938 ! dipeptide transport
relationship: negatively_regulates GO:0042938 ! dipeptide transport
created_by: rfoulger

[Term]
id: GO:0035956
name: regulation of starch catabolic process by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the breakdown of starch, by modulating the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:9342405]
synonym: "regulation of starch breakdown by regulation of transcription from Pol II promoter" EXACT [GGOC:obol]
synonym: "regulation of starch breakdown by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "regulation of starch catabolic process by regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "regulation of starch catabolism by regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "regulation of starch catabolism by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "regulation of starch degradation by regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "regulation of starch degradation by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:2000881 ! regulation of starch catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0005983 ! starch catabolic process
intersection_of: regulates GO:0006366 ! transcription from RNA polymerase II promoter
relationship: regulates GO:0005983 ! starch catabolic process
relationship: regulates GO:0006366 ! transcription from RNA polymerase II promoter
created_by: rfoulger

[Term]
id: GO:0035957
name: positive regulation of starch catabolic process by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the breakdown of starch, by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf]
synonym: "positive regulation of starch breakdown by regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "positive regulation of starch breakdown by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of starch catabolic process by regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "positive regulation of starch catabolism by regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "positive regulation of starch catabolism by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of starch degradation by regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "positive regulation of starch degradation by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol]
is_a: GO:0035956 ! regulation of starch catabolic process by regulation of transcription from RNA polymerase II promoter
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
is_a: GO:2000883 ! positive regulation of starch catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0005983 ! starch catabolic process
intersection_of: positively_regulates GO:0006366 ! transcription from RNA polymerase II promoter
relationship: positively_regulates GO:0005983 ! starch catabolic process
relationship: positively_regulates GO:0006366 ! transcription from RNA polymerase II promoter
created_by: rfoulger

[Term]
id: GO:0035958
name: regulation of glyoxylate cycle by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the glyoxylate cycle by modulating the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:11024040, PMID:17875938, PMID:19686338]
synonym: "regulation of glyoxylate bypass by regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "regulation of glyoxylate bypass by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "regulation of glyoxylate cycle by regulation of transcription from Pol II promoter" RELATED [GOC:obol]
is_a: GO:0072364 ! regulation of cellular ketone metabolic process by regulation of transcription from RNA polymerase II promoter
is_a: GO:2000874 ! regulation of glyoxylate cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006097 ! glyoxylate cycle
intersection_of: regulates GO:0006366 ! transcription from RNA polymerase II promoter
relationship: regulates GO:0006097 ! glyoxylate cycle
relationship: regulates GO:0006366 ! transcription from RNA polymerase II promoter
created_by: rfoulger

[Term]
id: GO:0035959
name: positive regulation of glyoxylate cycle by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the glyoxylate cycle by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:11024040, PMID:17875938, PMID:19686338]
synonym: "positive regulation of glyoxylate bypass by positive regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "positive regulation of glyoxylate bypass by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of glyoxylate bypass by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of glyoxylate bypass by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of glyoxylate bypass by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of glyoxylate cycle by activation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of glyoxylate cycle by positive regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "positive regulation of glyoxylate cycle by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of glyoxylate cycle by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of glyoxylate cycle by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of glyoxylate cycle by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
is_a: GO:0035958 ! regulation of glyoxylate cycle by regulation of transcription from RNA polymerase II promoter
is_a: GO:0072366 ! regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter
is_a: GO:2000876 ! positive regulation of glyoxylate cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006097 ! glyoxylate cycle
intersection_of: positively_regulates GO:0006366 ! transcription from RNA polymerase II promoter
relationship: positively_regulates GO:0006097 ! glyoxylate cycle
relationship: positively_regulates GO:0006366 ! transcription from RNA polymerase II promoter
created_by: rfoulger

[Term]
id: GO:0035960
name: regulation of ergosterol biosynthetic process by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ergosterol biosynthetic process by modulating the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:11533229, PMID:16055745]
synonym: "regulation of ergosterol anabolism by regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "regulation of ergosterol anabolism by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol]
synonym: "regulation of ergosterol biosynthesis by regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "regulation of ergosterol biosynthesis by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol]
synonym: "regulation of ergosterol biosynthetic process by regulation of transcription from Pol II promoter" RELATED [GOC:obol]
synonym: "regulation of ergosterol formation by regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "regulation of ergosterol formation by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol]
synonym: "regulation of ergosterol synthesis by regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "regulation of ergosterol synthesis by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0032443 ! regulation of ergosterol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: regulates GO:0006696 ! ergosterol biosynthetic process
relationship: regulates GO:0006366 ! transcription from RNA polymerase II promoter
relationship: regulates GO:0006696 ! ergosterol biosynthetic process
created_by: rfoulger

[Term]
id: GO:0035961
name: positive regulation of ergosterol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ergosterol biosynthesis by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:11533229]
synonym: "positive regulation of ergosterol anabolism by positive regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "positive regulation of ergosterol anabolism by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol]
synonym: "positive regulation of ergosterol anabolism by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of ergosterol anabolism by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of ergosterol anabolism by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of ergosterol biosynthesis by positive regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "positive regulation of ergosterol biosynthesis by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol]
synonym: "positive regulation of ergosterol biosynthesis by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of ergosterol biosynthesis by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of ergosterol biosynthesis by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of ergosterol biosynthetic process by activation of transcription from RNA polymerase II promoter" RELATED [GOC:obol]
synonym: "positive regulation of ergosterol biosynthetic process by positive regulation of transcription from Pol II promoter" RELATED [GOC:obol]
synonym: "positive regulation of ergosterol biosynthetic process by stimulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol]
synonym: "positive regulation of ergosterol biosynthetic process by up regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol]
synonym: "positive regulation of ergosterol biosynthetic process by up-regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol]
synonym: "positive regulation of ergosterol biosynthetic process by upregulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol]
synonym: "positive regulation of ergosterol formation by positive regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "positive regulation of ergosterol formation by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol]
synonym: "positive regulation of ergosterol formation by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of ergosterol formation by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of ergosterol formation by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of ergosterol synthesis by positive regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "positive regulation of ergosterol synthesis by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol]
synonym: "positive regulation of ergosterol synthesis by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of ergosterol synthesis by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of ergosterol synthesis by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
is_a: GO:0035960 ! regulation of ergosterol biosynthetic process by regulation of transcription from RNA polymerase II promoter
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
is_a: GO:0070452 ! positive regulation of ergosterol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: positively_regulates GO:0006696 ! ergosterol biosynthetic process
relationship: positively_regulates GO:0006366 ! transcription from RNA polymerase II promoter
relationship: positively_regulates GO:0006696 ! ergosterol biosynthetic process
created_by: rfoulger

[Term]
id: GO:0035962
name: response to interleukin-13
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-13 stimulus." [GOC:sjw, PMID:20100461]
synonym: "response to IL-13" EXACT [GOC:bf]
is_a: GO:0034097 ! response to cytokine
created_by: rfoulger
creation_date: 2011-08-01T11:29:02Z

[Term]
id: GO:0035963
name: cellular response to interleukin-13
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-13 stimulus." [GOC:sjw, PMID:20100461]
synonym: "cellular response to IL-13" EXACT [GOC:bf]
is_a: GO:0035962 ! response to interleukin-13
is_a: GO:0071345 ! cellular response to cytokine stimulus
created_by: rfoulger
creation_date: 2011-08-01T11:29:42Z

[Term]
id: GO:0035964
name: COPI-coated vesicle budding
namespace: biological_process
def: "The evagination of a Golgi membrane, resulting in formation of a COPI-coated vesicle." [GOC:br, PMID:10052452, PMID:17041781]
synonym: "COPI vesicle budding" EXACT [PMID:17041781]
is_a: GO:0048194 ! Golgi vesicle budding
relationship: occurs_in GO:0000139 ! Golgi membrane
relationship: part_of GO:0048199 ! vesicle targeting, to, from or within Golgi
created_by: rfoulger
creation_date: 2011-08-01T11:32:23Z

[Term]
id: GO:0035965
name: cardiolipin acyl-chain remodeling
namespace: biological_process
def: "Remodeling the acyl chains of premature (de novo synthesized) cardiolipin (1,3-bis(3-phosphatidyl)glycerol), through sequential deacylation and re-acylation reactions, to generate mature cardiolipin containing high-levels of unsaturated fatty acids." [GOC:bf, GOC:rb, PMID:19244244]
synonym: "cardiolipin acyl-chain remodelling" EXACT [GOC:bf]
synonym: "cardiolipin maturation" BROAD [GOC:rb]
synonym: "diphosphatidylglycerol remodeling" RELATED [CHEBI:28494]
is_a: GO:0032048 ! cardiolipin metabolic process
created_by: rfoulger
creation_date: 2011-08-03T11:17:49Z

[Term]
id: GO:0035966
name: response to topologically incorrect protein
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure." [GOC:bf]
synonym: "response to misfolded or unfolded protein" RELATED [GOC:bf]
is_a: GO:0006950 ! response to stress
is_a: GO:0010033 ! response to organic substance
created_by: rfoulger
creation_date: 2011-08-03T11:43:12Z

[Term]
id: GO:0035967
name: cellular response to topologically incorrect protein
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure." [GOC:bf]
synonym: "cellular response to misfolded or unfolded protein" RELATED [GOC:bf]
is_a: GO:0033554 ! cellular response to stress
is_a: GO:0035966 ! response to topologically incorrect protein
is_a: GO:0071310 ! cellular response to organic substance
created_by: rfoulger
creation_date: 2011-08-03T11:44:50Z

[Term]
id: GO:0035968
name: regulation of sterol import by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sterol import, by regulation of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:12077145]
synonym: "regulation of sterol import by regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "regulation of sterol influx by regulation of transcription from Pol II promoter" EXACT [GOC:bf]
synonym: "regulation of sterol influx by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:bf]
synonym: "regulation of sterol uptake by regulation of transcription from Pol II promoter" EXACT [GOC:bf]
synonym: "regulation of sterol uptake by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:bf]
is_a: GO:0072367 ! regulation of lipid transport by regulation of transcription from RNA polymerase II promoter
is_a: GO:2000909 ! regulation of sterol import
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: regulates GO:0035376 ! sterol import
relationship: regulates GO:0006366 ! transcription from RNA polymerase II promoter
relationship: regulates GO:0035376 ! sterol import
created_by: rfoulger

[Term]
id: GO:0035969
name: positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sterol import by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:11533229]
synonym: "positive regulation of sterol import by activation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of sterol import by positive regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "positive regulation of sterol import by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of sterol import by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of sterol import by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of sterol import by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of sterol influx by activation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of sterol influx by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of sterol influx by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of sterol influx by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of sterol influx by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of sterol influx by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of sterol uptake by activation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of sterol uptake by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of sterol uptake by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of sterol uptake by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of sterol uptake by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "positive regulation of sterol uptake by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
is_a: GO:0035968 ! regulation of sterol import by regulation of transcription from RNA polymerase II promoter
is_a: GO:0072369 ! regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter
is_a: GO:2000911 ! positive regulation of sterol import
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: positively_regulates GO:0035376 ! sterol import
relationship: positively_regulates GO:0006366 ! transcription from RNA polymerase II promoter
relationship: positively_regulates GO:0035376 ! sterol import
created_by: rfoulger

[Term]
id: GO:0035970
name: peptidyl-threonine dephosphorylation
namespace: biological_process
def: "The removal of phosphoric residues from peptidyl-O-phospho-L-threonine to form peptidyl-threonine." [GOC:bf]
is_a: GO:0006470 ! protein dephosphorylation
created_by: rfoulger
creation_date: 2011-08-08T02:57:11Z

[Term]
id: GO:0035971
name: peptidyl-histidine dephosphorylation
namespace: biological_process
def: "The removal of phosphoric residues from peptidyl-O-phospho-L-histidine to form peptidyl-histidine." [GOC:BHF, GOC:vk, PMID:12383260]
is_a: GO:0006470 ! protein dephosphorylation
created_by: rfoulger
creation_date: 2011-08-08T03:26:02Z

[Term]
id: GO:0035973
name: aggrephagy
namespace: biological_process
alt_id: GO:0035972
def: "Selective degradation of protein aggregates by macroautophagy." [GOC:autophagy, GOC:kmv, PMID:18508269, PMID:25062811]
is_a: GO:0016236 ! macroautophagy
created_by: rfoulger
creation_date: 2011-08-09T09:53:40Z

[Term]
id: GO:0035974
name: meiotic spindle pole body
namespace: cellular_component
def: "The microtubule organizing center on a spindle that forms as part of meiosis; functionally homologous to the animal cell centrosome." [GOC:vw, PMID:21775631]
is_a: GO:0005816 ! spindle pole body
relationship: part_of GO:0072687 ! meiotic spindle
created_by: rfoulger
creation_date: 2011-08-16T11:37:59Z

[Term]
id: GO:0035975
name: carbamoyl phosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of carbamoyl phosphate, an intermediate in the urea cycle and other nitrogen compound metabolic pathways." [CHEBI:17672, GOC:yaf, UniPathway:UPA00996]
subset: gosubset_prok
synonym: "carbamoyl phosphate breakdown" EXACT [GOC:bf]
synonym: "carbamoyl phosphate catabolism" EXACT [GOC:bf]
synonym: "carbamoyl phosphate degradation" EXACT [GOC:bf]
is_a: GO:0044270 ! cellular nitrogen compound catabolic process
is_a: GO:0046434 ! organophosphate catabolic process
is_a: GO:0070408 ! carbamoyl phosphate metabolic process
created_by: rfoulger
creation_date: 2011-08-16T11:41:13Z

[Term]
id: GO:0035976
name: AP1 complex
namespace: cellular_component
def: "A heterodimeric transcription factor complex composed of proteins from the c-Fos, c-Jun, activating transcription factor (ATF) or JDP families. The subunits contain a basic leucine zipper (bZIP) domain that is essential for dimerization and DNA binding. Jun-Fos heterodimers bind preferentially to a heptamer consensus sequence (TPA responsive element (TRE)), whereas Jun-ATF dimers bind the cyclic AMP responsive element (CRE) to regulate transcription of target genes." [GOC:bf, GOC:BHF, GOC:rl, PMID:20060892, PMID:9069263, Wikipedia:AP-1_transcription_factor]
synonym: "Activating protein 1 complex" EXACT [GOC:rl]
synonym: "AP-1 complex" EXACT [GOC:rl]
synonym: "transcription factor AP-1 complex" EXACT [GOC:rl]
synonym: "transcription factor AP1 complex" EXACT [GOC:rl]
is_a: GO:0090575 ! RNA polymerase II transcription factor complex
created_by: rfoulger
creation_date: 2011-08-17T10:57:51Z

[Term]
id: GO:0035977
name: protein deglycosylation involved in glycoprotein catabolic process
namespace: biological_process
def: "The removal of sugar residues from a glycosylated protein that contributes to the breakdown of a glycoprotein." [GOC:bf, GOC:vw]
is_a: GO:0006517 ! protein deglycosylation
intersection_of: GO:0006517 ! protein deglycosylation
intersection_of: part_of GO:0006516 ! glycoprotein catabolic process
relationship: part_of GO:0006516 ! glycoprotein catabolic process
created_by: rfoulger
creation_date: 2011-08-18T10:31:23Z

[Term]
id: GO:0035978
name: histone H2A-S139 phosphorylation
namespace: biological_process
def: "The modification of histone H2A by the addition of an phosphate group to a serine residue at position 139 of the histone." [GOC:yaf, PMID:16061642]
comment: Residue 1 of histone H2AX is taken as the first residue following removal of the initiating Methionine (Met).
synonym: "histone H2A.x phosphorylation at S139" NARROW [GOC:bf, PMID:16061642]
is_a: GO:0035404 ! histone-serine phosphorylation
is_a: GO:1990164 ! histone H2A phosphorylation
created_by: rfoulger
creation_date: 2011-08-22T11:34:09Z

[Term]
id: GO:0035979
name: histone kinase activity (H2A-S139 specific)
namespace: molecular_function
def: "Catalysis of the transfer of a phosphate group to the serine-139 residue of the C-terminal tail of histone H2A." [GOC:yaf, PMID:16061642]
comment: Residue 1 of histone H2A is taken as the first residue following removal of the initiating Methionine (Met).
synonym: "histone kinase activity (H2A.x-S139 specific)" NARROW [GOC:bf, PMID:16061642]
is_a: GO:0035174 ! histone serine kinase activity
relationship: part_of GO:0035978 ! histone H2A-S139 phosphorylation
created_by: rfoulger
creation_date: 2011-08-22T01:13:34Z

[Term]
id: GO:0035980
name: obsolete invasive growth in response to nitrogen limitation
namespace: biological_process
def: "OBSOLETE. The growth of colonies in filamentous chains of cells as a result of a reduced availability of nitrogen." [GOC:vw]
comment: This term was made obsolete because the GO term 'pseudohyphal growth ; GO:0007124' describes growth under nitrogen-limiting conditions.
synonym: "invasive growth in response to nitrogen limitation" EXACT []
is_obsolete: true
consider: GO:0007124
created_by: rfoulger
creation_date: 2011-08-22T01:20:39Z

[Term]
id: GO:0035981
name: tongue muscle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a tongue muscle cell." [CL:0002673, GOC:yaf, PMID:3393851]
is_a: GO:0098528 ! skeletal muscle fiber differentiation
created_by: rfoulger
creation_date: 2011-08-22T01:35:16Z

[Term]
id: GO:0035982
name: obsolete age-dependent behavioral decline
namespace: biological_process
def: "OBSOLETE. A developmental process that arises as an organism progresses toward the end of its lifespan that results in a decline in behavioral activities such as locomotory behavior, and learning or memory." [GOC:kmv, PMID:20523893]
comment: This term was made obsolete because it describes a phenotype.
synonym: "age-dependent behavioural decline" EXACT [GOC:bf]
synonym: "age-related behavioral decline" EXACT [GOC:kmv]
synonym: "behavioral aging" EXACT [GOC:kmv]
is_obsolete: true
replaced_by: GO:0090647
created_by: rfoulger
creation_date: 2011-08-23T01:30:55Z

[Term]
id: GO:0035983
name: response to trichostatin A
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trichostatin A stimulus." [CHEBI:46024, GOC:yaf, PMID:20181743]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0046677 ! response to antibiotic
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: rfoulger
creation_date: 2011-08-23T01:48:01Z

[Term]
id: GO:0035984
name: cellular response to trichostatin A
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trichostatin A stimulus." [CHEBI:46024, GOC:yaf, PMID:20181743]
is_a: GO:0035983 ! response to trichostatin A
is_a: GO:0071236 ! cellular response to antibiotic
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: rfoulger
creation_date: 2011-08-23T01:48:43Z

[Term]
id: GO:0035985
name: senescence-associated heterochromatin focus
namespace: cellular_component
def: "A transcriptionally-silent heterochromatin structure present in senescent cells. Contains the condensed chromatin of one chromosome and is enriched for histone modifications. Thought to repress expression of proliferation-promoting genes." [GOC:yaf, PMID:15621527, PMID:21248468]
synonym: "SAHF" EXACT [GOC:yaf]
synonym: "senescence-associated heterochromatin foci" EXACT [PMID:15621527, PMID:21248468]
is_a: GO:0000792 ! heterochromatin
created_by: rfoulger
creation_date: 2011-08-25T04:36:40Z

[Term]
id: GO:0035986
name: senescence-associated heterochromatin focus assembly
namespace: biological_process
def: "The assembly of chromatin into senescence-associated heterochromatin foci (SAHF), transcriptionally-silent heterochromatin structures present in senescent cells, containing the condensed chromatin of one chromosome, and enriched for histone modifications. Formation of these chromatin structures is thought to repress expression of proliferation-promoting genes." [GOC:yaf, PMID:15621527, PMID:21248468]
synonym: "SAHF formation" EXACT [GOC:yaf]
synonym: "senescence-associated heterochromatin foci formation" EXACT [GOC:yaf]
synonym: "senescence-associated heterochromatin focus formation" EXACT []
is_a: GO:0031507 ! heterochromatin assembly
created_by: rfoulger
creation_date: 2011-08-25T04:43:56Z

[Term]
id: GO:0035987
name: endodermal cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo." [CL:0000223, GOC:yaf, PMID:17624332]
synonym: "endoderm cell differentiation" EXACT [CL:0000223]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0001706 ! endoderm formation
created_by: rfoulger
creation_date: 2011-08-25T04:50:36Z

[Term]
id: GO:0035988
name: chondrocyte proliferation
namespace: biological_process
def: "The multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population. A chondrocyte is a polymorphic cell that forms cartilage." [CL:0000138, GOC:yaf, PMID:21484705]
synonym: "cartilage cell proliferation" EXACT [CL:0000138]
synonym: "chondrocyte cell proliferation" EXACT [GOC:bf]
is_a: GO:0008283 ! cell proliferation
created_by: rfoulger
creation_date: 2011-08-25T04:53:40Z

[Term]
id: GO:0035989
name: tendon development
namespace: biological_process
def: "The process whose specific outcome is the progression of a tendon over time, from its formation to the mature structure. A tendon is a fibrous, strong, connective tissue that connects muscle to bone or integument and is capable of withstanding tension. Tendons and muscles work together to exert a pulling force." [GOC:yaf, PMID:21412429, UBERON:0000043]
synonym: "sinew development" RELATED [UBERON:0000043]
is_a: GO:0061448 ! connective tissue development
created_by: rfoulger
creation_date: 2011-08-26T04:14:30Z

[Term]
id: GO:0035990
name: tendon cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a tendon cell. Tendon cell are elongated fibrocytes in which the cytoplasm is stretched between the collagen fibres of the tendon. Tendon cells have a central cell nucleus with a prominent nucleolus, a well-developed rough endoplasmic reticulum, and are responsible for synthesis and turnover of tendon fibres and ground substance." [CL:0000388, GOC:yaf, PMID:21412429]
synonym: "muscle attachment cell differentiation" EXACT [CL:0000388]
synonym: "tenocyte differentiation" RELATED [CL:0000388]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0035992 ! tendon formation
created_by: rfoulger
creation_date: 2011-08-26T04:16:06Z

[Term]
id: GO:0035991
name: nitric oxide sensor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with and responding, e.g. by conformational change, to changes in the cellular level of nitric oxide (NO)." [GOC:kmv, PMID:21491957]
synonym: "NO sensor activity" EXACT [CHEBI:16480]
is_a: GO:0070026 ! nitric oxide binding
relationship: part_of GO:0071731 ! response to nitric oxide
created_by: rfoulger
creation_date: 2011-08-26T04:32:16Z

[Term]
id: GO:0035992
name: tendon formation
namespace: biological_process
def: "The process that gives rise to a tendon. This process pertains to the initial formation of a tendon from unspecified parts." [GOC:yaf, PMID:17567668, UBERON:0000043]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0035989 ! tendon development
created_by: rfoulger
creation_date: 2011-08-30T01:35:10Z

[Term]
id: GO:0035993
name: deltoid tuberosity development
namespace: biological_process
def: "The process whose specific outcome is the progression of the deltoid tuberosity over time, from its formation to the mature structure. The deltoid tuberosity is the region on the shaft of the humerus to which the deltoid muscle attaches. The deltoid tuberosity develops through endochondral ossification in a two-phase process; an initiating tendon-dependent phase, and a muscle-dependent growth phase." [GOC:yaf, PMID:17567668, UBERON:0002498, Wikipedia:Deltoid_tuberosity]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0060173 ! limb development
relationship: part_of GO:0060348 ! bone development
created_by: rfoulger
creation_date: 2011-08-30T01:46:53Z

[Term]
id: GO:0035994
name: response to muscle stretch
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a myofibril being extended beyond its slack length." [GOC:BHF, GOC:vk, PMID:14583192]
is_a: GO:0009612 ! response to mechanical stimulus
created_by: rfoulger
creation_date: 2011-08-30T01:52:31Z

[Term]
id: GO:0035995
name: detection of muscle stretch
namespace: biological_process
def: "The series of events by which a muscle stretch stimulus is received by a cell and converted into a molecular signal." [PMID:14583192]
is_a: GO:0035994 ! response to muscle stretch
is_a: GO:0050982 ! detection of mechanical stimulus
created_by: rfoulger
creation_date: 2011-08-30T01:53:35Z

[Term]
id: GO:0035996
name: rhabdomere microvillus
namespace: cellular_component
def: "Thin cylindrical membrane-covered projection on the surface of a rhabdomere." [GOC:bf, GOC:sart, PMID:14744998]
is_a: GO:0005902 ! microvillus
is_a: GO:0044463 ! cell projection part
relationship: part_of GO:0016028 ! rhabdomere
created_by: rfoulger
creation_date: 2011-09-01T02:18:30Z

[Term]
id: GO:0035997
name: rhabdomere microvillus membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a microvillus of a rhabdomere." [GOC:bf, GOC:sart, PMID:14744998]
is_a: GO:0031528 ! microvillus membrane
relationship: part_of GO:0033583 ! rhabdomere membrane
relationship: part_of GO:0035996 ! rhabdomere microvillus
created_by: rfoulger
creation_date: 2011-09-01T02:24:20Z

[Term]
id: GO:0035998
name: 7,8-dihydroneopterin 3'-triphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 7,8-dihydroneopterin 3'-triphosphate." [CHEBI:18372, GOC:yaf, UniPathway:UPA00848]
synonym: "7,8-dihydroneopterin 3'-triphosphate anabolism" EXACT [GOC:bf]
synonym: "7,8-dihydroneopterin 3'-triphosphate biosynthesis" EXACT [GOC:bf]
synonym: "7,8-dihydroneopterin 3'-triphosphate formation" EXACT [GOC:bf]
synonym: "7,8-dihydroneopterin 3'-triphosphate synthesis" EXACT [GOC:bf]
xref: UniPathway:UPA00848
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0042559 ! pteridine-containing compound biosynthetic process
is_a: GO:0051066 ! dihydrobiopterin metabolic process
is_a: GO:0051188 ! cofactor biosynthetic process
is_a: GO:0090407 ! organophosphate biosynthetic process
created_by: rfoulger
creation_date: 2011-09-02T01:15:35Z

[Term]
id: GO:0035999
name: tetrahydrofolate interconversion
namespace: biological_process
def: "The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules." [GOC:yaf, PMID:1825999, UniPathway:UPA00193]
xref: MetaCyc:PWY-2201
xref: UniPathway:UPA00193
is_a: GO:0006730 ! one-carbon metabolic process
is_a: GO:0046653 ! tetrahydrofolate metabolic process
created_by: rfoulger
creation_date: 2011-09-02T01:35:49Z

[Term]
id: GO:0036000
name: mucocyst
namespace: cellular_component
def: "A small subcellular vesicle, surrounded by a membrane, in the pellicle of ciliate protozoans that discharges a mucus-like secretion." [GOC:mag, PMID:10723937, PMID:4629881]
is_a: GO:0030141 ! secretory granule
created_by: rfoulger
creation_date: 2011-09-06T01:32:17Z

[Term]
id: GO:0036001
name: 'de novo' pyridoxal 5'-phosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyridoxal 5'-phosphate, the active form of vitamin B6, from simpler components." [GOC:bf, GOC:yaf, MetaCyc:PYRIDOXSYN-PWY]
synonym: "'de novo' PLP biosynthesis" EXACT [MetaCyc:PYRIDOXSYN-PWY]
synonym: "'de novo' pyridoxal 5'-phosphate anabolism" EXACT [GOC:bf]
synonym: "'de novo' pyridoxal 5'-phosphate biosynthesis" EXACT [GOC:bf]
synonym: "'de novo' pyridoxal 5'-phosphate formation" EXACT [GOC:bf]
synonym: "'de novo' pyridoxal 5'-phosphate synthesis" EXACT [GOC:bf]
synonym: "'de novo' pyridoxal phosphate biosynthetic process" BROAD [GOC:bf]
xref: MetaCyc:PYRIDOXSYN-PWY
is_a: GO:0042823 ! pyridoxal phosphate biosynthetic process
created_by: rfoulger
creation_date: 2011-09-06T02:04:53Z

[Term]
id: GO:0036002
name: pre-mRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule." [GOC:bf, GOC:kmv, PMID:21901112, SO:0000120]
synonym: "protein-coding primary transcript binding" RELATED [SO:0000120]
is_a: GO:0003723 ! RNA binding
created_by: rfoulger
creation_date: 2011-09-16T10:23:37Z

[Term]
id: GO:0036003
name: positive regulation of transcription from RNA polymerase II promoter in response to stress
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mcc]
is_a: GO:0043618 ! regulation of transcription from RNA polymerase II promoter in response to stress
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
created_by: rfoulger
creation_date: 2011-09-19T03:00:18Z

[Term]
id: GO:0036004
name: GAF domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the GAF domain of a protein." [GOC:yaf, InterPro:IPR003018]
is_a: GO:0019904 ! protein domain specific binding
created_by: rfoulger
creation_date: 2011-09-20T04:20:42Z

[Term]
id: GO:0036005
name: response to macrophage colony-stimulating factor
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a macrophage colony-stimulating factor stimulus." [GOC:yaf, PMID:14687666]
synonym: "response to M-CSF" EXACT [GOC:bf, PMID:14687666]
synonym: "response to macrophage colony-stimulating factor" EXACT [GOC:bf]
synonym: "response to macrophage colony-stimulating factor stimulus" EXACT [GOC:dos]
is_a: GO:0034097 ! response to cytokine
created_by: rfoulger
creation_date: 2011-09-20T04:22:03Z

[Term]
id: GO:0036006
name: cellular response to macrophage colony-stimulating factor stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a macrophage colony-stimulating factor stimulus." [GOC:yaf, PMID:14687666]
synonym: "cellular response to M-CSF stimulus" EXACT [GOC:bf, PMID:14687666]
synonym: "cellular response to macrophage colony-stimulating factor" EXACT [GOC:bf]
is_a: GO:0036005 ! response to macrophage colony-stimulating factor
is_a: GO:0071345 ! cellular response to cytokine stimulus
created_by: rfoulger
creation_date: 2011-09-20T04:23:19Z

[Term]
id: GO:0036007
name: scintillon
namespace: cellular_component
def: "A body present in the cytoplasm of some dinoflagellates, which is the source of bioluminescence; emits light on acidification in the presence of oxygen." [GOC:mag, GOC:pr, PMID:4501583, PMID:5642469]
is_a: GO:0044444 ! cytoplasmic part
created_by: rfoulger
creation_date: 2011-09-21T03:04:02Z

[Term]
id: GO:0036008
name: sucrose catabolic process to fructose-6-phosphate and glucose-6-phosphate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of sucrose, which proceeds by phosphorylation of sucrose to form sucrose-6-phosphate. The subsequent actions of a hydrolase and a fructokinase generate fructose-6-phosphate and glucose-6-phosphate." [GOC:bf, GOC:dgf, MetaCyc:SUCUTIL-PWY]
xref: MetaCyc:SUCUTIL-PWY
is_a: GO:0005987 ! sucrose catabolic process
is_a: GO:0006002 ! fructose 6-phosphate metabolic process
is_a: GO:0051156 ! glucose 6-phosphate metabolic process
relationship: has_part GO:0008865 ! fructokinase activity
relationship: has_part GO:0050307 ! sucrose-phosphate phosphatase activity
created_by: rfoulger
creation_date: 2011-09-23T10:34:08Z

[Term]
id: GO:0036009
name: protein-glutamine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + protein L-glutamine = S-adenosyl-L-homocysteine + protein N-methyl-L-glutamine." [GOC:imk, PMID:11847124]
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0008276 ! protein methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
created_by: rfoulger
creation_date: 2011-10-03T02:27:05Z

[Term]
id: GO:0036010
name: protein localization to endosome
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within an endosome." [GOC:yaf]
synonym: "protein localisation in endosome" EXACT [GOC:bf]
synonym: "protein localization in endosome" EXACT [GOC:curators]
is_a: GO:0072665 ! protein localization to vacuole
created_by: rfoulger
creation_date: 2011-10-06T02:42:18Z

[Term]
id: GO:0036011
name: imaginal disc-derived leg segmentation
namespace: biological_process
def: "Division of an imaginal disc-derived leg into a series of semi-repetitive parts or segments. The Drosophila leg, for example, has nine segments, each separated from the next by a flexible joint." [GOC:bf]
is_a: GO:0035285 ! appendage segmentation
relationship: part_of GO:0007480 ! imaginal disc-derived leg morphogenesis
created_by: rfoulger
creation_date: 2011-10-07T04:37:17Z

[Term]
id: GO:0036012
name: cyanelle inner membrane
namespace: cellular_component
def: "The inner, i.e. lumen-facing, lipid bilayer of the cyanelle envelope; also faces the cyanelle stroma." [GOC:aa, PMID:18976493]
synonym: "cyanelle inner envelope membrane" EXACT [PMID:18976493]
is_a: GO:0009528 ! plastid inner membrane
is_a: GO:0033113 ! cyanelle membrane
created_by: rfoulger
creation_date: 2011-10-10T01:48:56Z

[Term]
id: GO:0036013
name: cyanelle outer membrane
namespace: cellular_component
def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the cyanelle envelope." [GOC:aa]
is_a: GO:0009527 ! plastid outer membrane
is_a: GO:0033113 ! cyanelle membrane
created_by: rfoulger
creation_date: 2011-10-10T01:50:56Z

[Term]
id: GO:0036014
name: cyanelle intermembrane space
namespace: cellular_component
def: "The region between the inner and outer lipid bilayers of the cyanelle envelope; includes the peptidoglycan layer." [GOC:aa]
synonym: "cyanelle envelope lumen" EXACT [GOC:bf]
synonym: "cyanelle periplasm" EXACT [PMID:18976493]
is_a: GO:0009529 ! plastid intermembrane space
relationship: part_of GO:0033112 ! cyanelle envelope
created_by: rfoulger
creation_date: 2011-10-10T02:12:28Z

[Term]
id: GO:0036015
name: response to interleukin-3
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-3 stimulus." [GOC:yaf, PR:000001387]
synonym: "response to IL-3" EXACT [GOC:bf]
is_a: GO:0034097 ! response to cytokine
created_by: rfoulger
creation_date: 2011-10-12T10:08:26Z

[Term]
id: GO:0036016
name: cellular response to interleukin-3
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-3 stimulus." [GOC:yaf, PR:000001387]
synonym: "cellular response to IL-3" EXACT [GOC:bf]
is_a: GO:0036015 ! response to interleukin-3
is_a: GO:0071345 ! cellular response to cytokine stimulus
created_by: rfoulger
creation_date: 2011-10-12T10:09:10Z

[Term]
id: GO:0036017
name: response to erythropoietin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythropoietin stimulus. Erythropoietin is a glycoprotein hormone that controls erythropoiesis." [GOC:yaf, PR:000007141]
is_a: GO:0034097 ! response to cytokine
created_by: rfoulger
creation_date: 2011-10-12T10:11:04Z

[Term]
id: GO:0036018
name: cellular response to erythropoietin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythropoietin stimulus." [GOC:yaf, PR:000007141]
is_a: GO:0036017 ! response to erythropoietin
is_a: GO:0071345 ! cellular response to cytokine stimulus
created_by: rfoulger
creation_date: 2011-10-12T10:12:18Z

[Term]
id: GO:0036019
name: endolysosome
namespace: cellular_component
def: "An transient hybrid organelle formed by fusion of a late endosome with a lysosome, and in which active degradation takes place." [GOC:pde, PMID:21878991]
is_a: GO:0005764 ! lysosome
is_a: GO:0005768 ! endosome
created_by: rfoulger
creation_date: 2011-10-13T02:35:13Z

[Term]
id: GO:0036020
name: endolysosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding an endolysosome. An endolysosome is a transient hybrid organelle formed by fusion of a late endosome with a lysosome." [GOC:pde]
synonym: "endolysosomal membrane" EXACT [GOC:bf]
is_a: GO:0005765 ! lysosomal membrane
is_a: GO:0010008 ! endosome membrane
relationship: part_of GO:0036019 ! endolysosome
created_by: rfoulger
creation_date: 2011-10-13T04:32:00Z

[Term]
id: GO:0036021
name: endolysosome lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of an endolysosome. An endolysosome is a transient hybrid organelle formed by fusion of a late endosome with a lysosome." [GOC:pde]
synonym: "endolysosomal lumen" EXACT [GOC:bf]
is_a: GO:0031904 ! endosome lumen
is_a: GO:0043202 ! lysosomal lumen
relationship: part_of GO:0036019 ! endolysosome
created_by: rfoulger
creation_date: 2011-10-13T04:32:31Z

[Term]
id: GO:0036022
name: limb joint morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a limb joint are generated and organized. A limb joint is a flexible region that separates the rigid sections of a limb to allow movement in a controlled manner." [GOC:bf]
synonym: "knee morphogenesis" NARROW [GOC:bf]
synonym: "leg joint morphogenesis" NARROW [GOC:bf]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0035108 ! limb morphogenesis
created_by: rfoulger
creation_date: 2011-10-13T04:52:59Z

[Term]
id: GO:0036023
name: embryonic skeletal limb joint morphogenesis
namespace: biological_process
def: "The process, occurring in the embryo, in which the anatomical structures of a skeletal limb joint are generated and organized. A skeletal limb joint is the connecting structure between the bones of a limb." [GOC:bf, Wikipedia:Joint]
is_a: GO:0036022 ! limb joint morphogenesis
is_a: GO:0060272 ! embryonic skeletal joint morphogenesis
relationship: part_of GO:0030326 ! embryonic limb morphogenesis
created_by: rfoulger
creation_date: 2011-10-13T04:57:39Z

[Term]
id: GO:0036024
name: protein C inhibitor-TMPRSS7 complex
namespace: cellular_component
def: "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and transmembrane protease serine 7 (TMPRSS7); formation of the complex inhibits the serine protease activity of transmembrane protease serine 7." [GOC:ans, PMID:15853774]
synonym: "PCI-TMPRSS7 complex" EXACT [PR:000014685]
synonym: "plasma serine protease inhibitor-TMPRSS7 complex" EXACT [PR:000014685]
synonym: "protein C inhibitor-matriptase-3 complex" EXACT [PMID:15853774, PR:000016461]
synonym: "protein C inhibitor-transmembrane protease serine 7 complex" EXACT [PR:000016461]
synonym: "serpin A5-TMPRSS7 complex" EXACT [PR:000014685]
synonym: "SERPINA5-TMPRSS7 complex" EXACT [PR:000014685]
is_a: GO:0097180 ! serine protease inhibitor complex
created_by: rfoulger
creation_date: 2011-10-19T01:25:06Z

[Term]
id: GO:0036025
name: protein C inhibitor-TMPRSS11E complex
namespace: cellular_component
def: "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and transmembrane protease serine 11E (TMPRSS11E); formation of the complex inhibits the serine protease activity of transmembrane protease serine 11E." [GOC:ans, PMID:15328353]
synonym: "PCI-TMPRSS11E complex" EXACT [PR:000014685]
synonym: "plasma serine protease inhibitor-TMPRSS11E complex" EXACT [PR:000014685]
synonym: "protein C inhibitor-transmembrane protease serine 11E complex" EXACT [PR:000016451]
synonym: "serpin A5-TMPRSS11E complex" EXACT [PR:000014685]
synonym: "SERPINA5-TMPRSS11E complex" EXACT [PR:000014685]
is_a: GO:0097180 ! serine protease inhibitor complex
created_by: rfoulger
creation_date: 2011-10-19T01:29:08Z

[Term]
id: GO:0036026
name: protein C inhibitor-PLAT complex
namespace: cellular_component
def: "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and tissue-type plasminogen activator (PLAT); formation of the complex inhibits the serine protease activity of tissue-type plasminogen activator." [GOC:ans, PMID:10340997]
synonym: "PCI-PLAT complex" EXACT [PR:000014685]
synonym: "plasma serine protease inhibitor-PLAT complex" EXACT [PR:000014685]
synonym: "protein C inhibitor-tissue-type plasminogen activator complex" EXACT [PMID:10340997, PR:000012825]
synonym: "protein C inhibitor-tPA complex" EXACT [PMID:10340997, PR:000012825]
synonym: "serpin A5-PLAT complex" EXACT [PR:000014685]
synonym: "SERPINA5-PLAT complex" EXACT [PR:000014685]
is_a: GO:0097180 ! serine protease inhibitor complex
created_by: rfoulger
creation_date: 2011-10-19T01:30:56Z

[Term]
id: GO:0036027
name: protein C inhibitor-PLAU complex
namespace: cellular_component
def: "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and urokinase-type plasminogen activator (PLAU); formation of the complex inhibits the serine protease activity of urokinase-type plasminogen activator." [GOC:ans, PMID:10340997, PMID:3501295, PMID:8536714]
synonym: "PCI-PLAU complex" EXACT [PR:000014685]
synonym: "plasma serine protease inhibitor-PLAU complex" EXACT [PR:000014685]
synonym: "protein C inhibitor-U-plasminogen activator complex" EXACT [PR:000012826]
synonym: "protein C inhibitor-uPA complex" EXACT [PR:000012826]
synonym: "protein C inhibitor-urokinase-type plasminogen activator complex" EXACT [PR:000012826]
synonym: "serpin A5-PLAU complex" EXACT [PR:000014685]
synonym: "SERPINA5-PLAU complex" EXACT [PR:000014685]
is_a: GO:0097180 ! serine protease inhibitor complex
created_by: rfoulger
creation_date: 2011-10-19T01:37:03Z

[Term]
id: GO:0036028
name: protein C inhibitor-thrombin complex
namespace: cellular_component
def: "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and thrombin (F2); formation of the complex inhibits the serine protease activity of thrombin." [GOC:ans, PMID:6323392]
synonym: "PCI-thrombin complex" EXACT [PR:000014685]
synonym: "plasma serine protease inhibitor-thrombin complex" EXACT [PR:000014685]
synonym: "protein C inhibitor-coagulation factor II complex" EXACT [PR:000007299]
synonym: "protein C inhibitor-F2 complex" EXACT [PR:000007299]
synonym: "serpin A5-thrombin complex" EXACT [PR:000014685]
synonym: "SERPINA5-thrombin complex" EXACT [PR:000014685]
is_a: GO:0097180 ! serine protease inhibitor complex
created_by: rfoulger
creation_date: 2011-10-19T01:40:18Z

[Term]
id: GO:0036029
name: protein C inhibitor-KLK3 complex
namespace: cellular_component
def: "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and prostate-specific antigen (KLK3); formation of the complex inhibits the serine protease activity of prostate-specific antigen." [GOC:ans, PMID:1725227]
synonym: "PCI-KLK3 complex" EXACT [PR:000014685]
synonym: "plasma serine protease inhibitor-KLK3 complex" EXACT [PR:000014685]
synonym: "protein C inhibitor-kallikrein-3 complex" EXACT [PR:000003015]
synonym: "protein C inhibitor-prostate-specific antigen complex" EXACT [PR:000003015]
synonym: "serpin A5-KLK3 complex" EXACT [PR:000014685]
synonym: "SERPINA5-KLK3 complex" EXACT [PR:000014685]
is_a: GO:0097180 ! serine protease inhibitor complex
created_by: rfoulger
creation_date: 2011-10-19T02:01:33Z

[Term]
id: GO:0036030
name: protein C inhibitor-plasma kallikrein complex
namespace: cellular_component
def: "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and plasma kallikrein (KLK1B); formation of the complex inhibits the serine protease activity of plasma kallikrein." [GOC:ans, PMID:2844223, PMID:8536714]
synonym: "PCI-plasma kallikrein complex" EXACT [PR:000014685]
synonym: "plasma serine protease inhibitor-plasma kallikrein complex" EXACT [PR:000014685]
synonym: "protein C inhibitor-KLKB1 complex" EXACT [PR:000009420]
synonym: "serpin A5-plasma kallikrein complex" EXACT [PR:000014685]
synonym: "SERPINA5-plasma kallikrein complex" EXACT [PR:000014685]
is_a: GO:0097180 ! serine protease inhibitor complex
created_by: rfoulger
creation_date: 2011-10-19T02:05:46Z

[Term]
id: GO:0036031
name: recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex
namespace: biological_process
def: "The process in which the guanylyltransferase enzyme responsible for adding a 7-methylguanosine cap on pre-mRNA becomes associated with the RNA polymerase II holoenzyme complex and the 5' end of a transcript." [GOC:bf, GOC:rb, PMID:10594013]
synonym: "capping enzyme targeting to RNA polymerase II" EXACT [PMID:10594013]
synonym: "recruitment of guanylyltransferase to RNA polymerase II holoenzyme complex" EXACT [GOC:bf]
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0006370 ! 7-methylguanosine mRNA capping
created_by: rfoulger
creation_date: 2011-10-24T10:56:46Z

[Term]
id: GO:0036032
name: neural crest cell delamination
namespace: biological_process
def: "The negative regulation of cell adhesion process in which a neural crest cell physically separates from the rest of the neural tube." [CL:0000333, PMID:17076275]
synonym: "neural crest cell emigration" EXACT [PMID:17076275]
synonym: "neural crest cell individualization" EXACT [PMID:17076275]
synonym: "neural crest cell segregation" RELATED [PMID:17076275]
is_a: GO:0060232 ! delamination
created_by: rfoulger
creation_date: 2011-10-31T03:50:30Z

[Term]
id: GO:0036033
name: mediator complex binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a mediator complex. The mediator complex is a protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [GOC:yaf, PMID:18391015]
is_a: GO:0032403 ! protein complex binding
created_by: rfoulger
creation_date: 2011-10-31T05:09:12Z

[Term]
id: GO:0036034
name: mediator complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a mediator complex. The mediator complex is a protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [GOC:yaf, PMID:17641689]
is_a: GO:0043623 ! cellular protein complex assembly
created_by: rfoulger
creation_date: 2011-10-31T05:18:11Z

[Term]
id: GO:0036035
name: osteoclast development
namespace: biological_process
def: "The process whose specific outcome is the progression of a osteoclast from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue." [CL:0000092, GOC:bf, GOC:yaf]
synonym: "osteoclast cell development" EXACT [GOC:bf]
is_a: GO:0061515 ! myeloid cell development
is_a: GO:0098751 ! bone cell development
relationship: part_of GO:0030316 ! osteoclast differentiation
created_by: rfoulger
creation_date: 2011-11-02T05:20:35Z

[Term]
id: GO:0036036
name: cardiac neural crest cell delamination
namespace: biological_process
def: "The negative regulation of cell adhesion process in which a cardiac neural crest cell physically separates from the rest of the neural tube." [GOC:hjd, PMID:17076275, PMID:18539270, PMID:20490374]
is_a: GO:0036032 ! neural crest cell delamination
created_by: rfoulger
creation_date: 2011-11-02T05:23:29Z

[Term]
id: GO:0036037
name: CD8-positive, alpha-beta T cell activation
namespace: biological_process
def: "The change in morphology and behavior of a CD8-positive, alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [CL:0000625, GOC:yaf]
is_a: GO:0046631 ! alpha-beta T cell activation
created_by: rfoulger
creation_date: 2011-11-03T10:34:12Z

[Term]
id: GO:0036038
name: TCTN-B9D complex
namespace: cellular_component
def: "A protein complex that is located at the ciliary transition zone and consists of tectonic proteins, B9 domain-containing proteins and other proteins. Acts as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. In mouse, members of the complex include TCTN1, TCTN2, B9D1, MKS1, CC2D2A and other proteins." [GOC:sp, PMID:21725307, PMID:22179047]
synonym: "B9 complex" NARROW []
synonym: "tectonic complex" NARROW []
synonym: "tectonic-like complex" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044441 ! ciliary part
relationship: part_of GO:0035869 ! ciliary transition zone
created_by: rfoulger
creation_date: 2011-11-22T11:21:28Z

[Term]
id: GO:0036039
name: curcumin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the polyphenol, curcumin." [CHEBI:3962, PMID:21467222]
synonym: "(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione metabolic process" EXACT [GOC:obol]
synonym: "(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione metabolism" EXACT [GOC:obol]
synonym: "curcumin metabolism" EXACT [GOC:obol]
synonym: "diferuloylmethane metabolic process" EXACT [GOC:obol]
synonym: "diferuloylmethane metabolism" EXACT [GOC:obol]
synonym: "turmeric yellow metabolic process" EXACT [GOC:obol]
synonym: "turmeric yellow metabolism" EXACT [GOC:obol]
is_a: GO:0018904 ! ether metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0042180 ! cellular ketone metabolic process
created_by: rfoulger
creation_date: 2011-11-22T01:58:57Z

[Term]
id: GO:0036040
name: curcumin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the polyphenol, curcumin." [CHEBI:3962, PMID:21467222]
synonym: "(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione breakdown" EXACT [GOC:obol]
synonym: "(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione catabolic process" EXACT [GOC:obol]
synonym: "(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione catabolism" EXACT [GOC:obol]
synonym: "(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione degradation" EXACT [GOC:obol]
synonym: "curcumin breakdown" EXACT [GOC:obol]
synonym: "curcumin catabolism" EXACT [GOC:obol]
synonym: "curcumin degradation" EXACT [GOC:obol]
synonym: "diferuloylmethane breakdown" EXACT [GOC:obol]
synonym: "diferuloylmethane catabolic process" EXACT [GOC:obol]
synonym: "diferuloylmethane catabolism" EXACT [GOC:obol]
synonym: "diferuloylmethane degradation" EXACT [GOC:obol]
synonym: "turmeric yellow breakdown" EXACT [GOC:obol]
synonym: "turmeric yellow catabolic process" EXACT [GOC:obol]
synonym: "turmeric yellow catabolism" EXACT [GOC:obol]
synonym: "turmeric yellow degradation" EXACT [GOC:obol]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0036039 ! curcumin metabolic process
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:1901502 ! ether catabolic process
created_by: rfoulger
creation_date: 2011-11-22T02:01:05Z

[Term]
id: GO:0036041
name: long-chain fatty acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a long-chain fatty acid. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [CHEBI:15904, GOC:pm, PMID:12641450]
synonym: "long chain fatty acid binding" EXACT [PMID:12641450]
is_a: GO:0005504 ! fatty acid binding
created_by: rfoulger
creation_date: 2011-11-24T02:54:39Z

[Term]
id: GO:0036042
name: long-chain fatty acyl-CoA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a long-chain fatty acyl-CoA. A long-chain fatty acyl-CoA is any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more." [CHEBI:33184, GOC:pm]
is_a: GO:0000062 ! fatty-acyl-CoA binding
created_by: rfoulger
creation_date: 2011-11-24T04:31:09Z

[Term]
id: GO:0036043
name: obsolete microspike
namespace: cellular_component
def: "OBSOLETE. A dynamic, actin-rich projection extending from the surface of a migrating animal cell." [PMID:11429692, PMID:12153987, PMID:19095735]
comment: This term was made obsolete because it accidentally reused an exisiting id. See replacement term GO:0044393.
synonym: "microspike" EXACT []
is_obsolete: true
replaced_by: GO:0044393
created_by: rfoulger
creation_date: 2011-12-06T01:31:16Z

[Term]
id: GO:0036044
name: obsolete protein malonylation
namespace: biological_process
def: "OBSOLETE: The modification of a protein amino acid by the addition of a malonyl (CO-CH2-CO) group." [CHEBI:25134, GOC:sp]
comment: This term was made obsolete because it accidentally shared the same ID as negative regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway by negative regulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity. New id is GO:0044394.
synonym: "protein malonylation" EXACT []
is_obsolete: true
replaced_by: GO:0044394

[Term]
id: GO:0036045
name: obsolete peptidyl-lysine malonylation
namespace: biological_process
def: "OBSOLETE. The addition of a malonyl group (CO-CH2-CO) to peptidyl-lysine to form N6-malonyl-L-lysine." [GOC:jsg, GOC:sp, PMID:21908771, PMID:22076378, RESID:AA0568]
comment: This term was made obsolete because it accidentally reused an exisiting id. See replacement term GO:0044392.
synonym: "lysine malonylation" EXACT [PMID:21908771]
synonym: "peptidyl-lysine malonylation" EXACT []
xref: RESID:AA0568
is_obsolete: true
replaced_by: GO:0044392
created_by: rfoulger
creation_date: 2011-12-12T09:31:42Z

[Term]
id: GO:0036046
name: protein demalonylation
namespace: biological_process
def: "The removal of a malonyl group (CO-CH2-CO), from an amino acid residue within a protein or peptide." [GOC:sp, PMID:22076378]
is_a: GO:0035601 ! protein deacylation
created_by: rfoulger
creation_date: 2011-12-12T09:38:26Z

[Term]
id: GO:0036047
name: peptidyl-lysine demalonylation
namespace: biological_process
def: "The process of removing a malonyl group (CO-CH2-CO) from an malonylated lysine residue in a peptide or protein." [GOC:sp, PMID:22076378]
is_a: GO:0018205 ! peptidyl-lysine modification
is_a: GO:0036046 ! protein demalonylation
created_by: rfoulger
creation_date: 2011-12-12T09:39:17Z

[Term]
id: GO:0036048
name: protein desuccinylation
namespace: biological_process
def: "The removal of a succinyl group (CO-CH2-CH2-CO) from a residue in a peptide or protein." [CHEBI:37952, GOC:sp, PMID:22076378]
is_a: GO:0035601 ! protein deacylation
created_by: rfoulger
creation_date: 2011-12-12T09:42:35Z

[Term]
id: GO:0036049
name: peptidyl-lysine desuccinylation
namespace: biological_process
def: "The removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue in a peptide or protein." [CHEBI:37952, GOC:sp, PMID:22076378]
is_a: GO:0018205 ! peptidyl-lysine modification
is_a: GO:0036048 ! protein desuccinylation
created_by: rfoulger
creation_date: 2011-12-12T09:44:54Z

[Term]
id: GO:0036050
name: peptidyl-lysine succinylation
namespace: biological_process
def: "The modification of a peptidyl-lysine residue by the addition of a succinyl group (CO-CH2-CH2-CO) to form N6-succinyl-L-lysine." [CHEBI:37952, GOC:jsg, GOC:sp, PMID:21151122, RESID:AA0545]
xref: RESID:AA0545
is_a: GO:0018205 ! peptidyl-lysine modification
is_a: GO:0018335 ! protein succinylation
created_by: rfoulger
creation_date: 2011-12-12T09:51:27Z

[Term]
id: GO:0036051
name: protein localization to trailing edge
namespace: biological_process
def: "A process in which a protein is transported to, or maintained at, the trailing edge. The trailing edge is the area of a motile cell opposite to the direction of movement." [GOC:pf, GOC:pg]
synonym: "protein localisation to trailing edge" EXACT [GOC:mah]
is_a: GO:0034613 ! cellular protein localization
created_by: rfoulger
creation_date: 2011-12-12T10:44:04Z

[Term]
id: GO:0036052
name: protein localization to uropod
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a uropod. A uropod is a membrane projection with related cytoskeletal components at the trailing edge of a migrating cell." [GOC:add, GOC:pf, ISBN:0781735149, PMID:12714569, PMID:12787750]
synonym: "protein localisation to uropod" EXACT [GOC:mah]
is_a: GO:0036051 ! protein localization to trailing edge
created_by: rfoulger
creation_date: 2011-12-12T10:45:26Z

[Term]
id: GO:0036053
name: glomerular endothelium fenestra
namespace: cellular_component
def: "A large plasma membrane-lined circular pore that perforates the flattened glomerular endothelium and, unlike those of other fenestrated capillaries, is not spanned by diaphragms; the density and size of glomerular fenestrae account, at least in part, for the high permeability of the glomerular capillary wall to water and small solutes." [GOC:cjm, MP:0011454, PMID:19129259]
synonym: "GEnC fenestration" EXACT [PMID:19129259]
synonym: "glomerular endothelial cell fenestration" EXACT [PMID:19129259]
is_a: GO:0046930 ! pore complex
created_by: rfoulger
creation_date: 2011-12-12T10:53:24Z

[Term]
id: GO:0036054
name: protein-malonyllysine demalonylase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein-malonyllysine + H2O => protein-lysine + malonate. This reaction is the removal of a malonyl group (CO-CH2-CO) from a malonylated lysine residue of a protein or peptide." [GOC:sp, PMID:21908771, PMID:22076378]
synonym: "peptidyl-malonyllysine demalonylase activity" EXACT []
synonym: "protein lysine demalonylation activity" EXACT [PMID:21908771]
synonym: "protein malonyl lysine demalonylation activity" EXACT [GOC:bf]
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
relationship: part_of GO:0036047 ! peptidyl-lysine demalonylation
created_by: rfoulger
creation_date: 2011-12-12T01:29:21Z

[Term]
id: GO:0036055
name: protein-succinyllysine desuccinylase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein-succinyllysine + H2O => protein-lysine + succinate. This reaction is the removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue of a protein or peptide." [GOC:sp, PMID:22076378]
synonym: "peptidyl-succinyllysine desuccinylase activity" EXACT []
synonym: "succinyl lysine desuccinylase activity" BROAD [GOC:bf]
synonym: "succinyllysine desuccinylase activity" BROAD []
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
relationship: part_of GO:0036049 ! peptidyl-lysine desuccinylation
created_by: rfoulger
creation_date: 2011-12-12T01:33:51Z

[Term]
id: GO:0036056
name: filtration diaphragm
namespace: cellular_component
def: "A specialized cell-cell junction found between the cells of the excretory system, which provides a barrier for filtration of blood or hemolymph." [GOC:mtg_kidney_jan10, GOC:sart, PMID:18971929]
is_a: GO:0005911 ! cell-cell junction
created_by: rfoulger
creation_date: 2011-12-12T04:36:05Z

[Term]
id: GO:0036057
name: slit diaphragm
namespace: cellular_component
def: "A specialized cell-cell junction found between the interdigitating foot processes of the glomerular epithelium (the podocytes) in the vertebrate kidney, which is adapted for facilitating glomerular filtration." [GOC:mtg_kidney_jan10, GOC:rph, PMID:12386277, PMID:15994232, PMID:18971929, PMID:19478094]
is_a: GO:0036056 ! filtration diaphragm
created_by: rfoulger
creation_date: 2011-12-12T04:36:42Z

[Term]
id: GO:0036058
name: filtration diaphragm assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a filtration diaphragm, a specialized cell-cell junction found between the cells of the excretory system, which provides a barrier for filtration of blood or hemolymph." [GOC:mtg_kidney_jan10, PMID:18971929]
is_a: GO:0007043 ! cell-cell junction assembly
created_by: rfoulger
creation_date: 2011-12-12T04:38:40Z

[Term]
id: GO:0036059
name: nephrocyte diaphragm assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a nephrocyte diaphragm, a specialized cell-cell junction found between nephrocytes of the insect kidney." [GOC:mtg_kidney_jan10, GOC:sart, PMID:18971929]
is_a: GO:0034333 ! adherens junction assembly
is_a: GO:0036058 ! filtration diaphragm assembly
created_by: rfoulger
creation_date: 2011-12-12T04:38:40Z

[Term]
id: GO:0036060
name: slit diaphragm assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a slit diaphragm, specialized cell-cell junction found between the interdigitating foot processes of the glomerular epithelium (the podocytes) in the vertebrate kidney, which is adapted for facilitating glomerular filtration." [GOC:mtg_kidney_jan10, GOC:rph, PMID:20633639]
is_a: GO:0036058 ! filtration diaphragm assembly
created_by: rfoulger
creation_date: 2011-12-12T04:38:40Z

[Term]
id: GO:0036061
name: muscle cell chemotaxis toward tendon cell
namespace: biological_process
def: "The directed movement of a muscle cell towards a tendon cell in response to an external stimulus. Tendon cells, for example, produce positive guidance cues that attract muscle cells." [GOC:sart, PMID:19793885]
synonym: "muscle cell attraction" RELATED [GOC:bf]
synonym: "muscle cell chemotaxis towards tendon cell" EXACT [GOC:bf, GOC:sart]
is_a: GO:0014812 ! muscle cell migration
is_a: GO:0060326 ! cell chemotaxis
created_by: rfoulger
creation_date: 2011-12-14T11:13:40Z

[Term]
id: GO:0036062
name: presynaptic periactive zone
namespace: cellular_component
def: "A region that surrounds the active zone of the presynaptic plasma membrane, and is specialized for the control of synaptic development." [GOC:sart, PMID:10976048, PMID:18439406]
subset: goslim_synapse
synonym: "periactive zone" EXACT [PMID:10976048, PMID:18439406]
synonym: "pre-synaptic periactive zone" EXACT []
is_a: GO:0097060 ! synaptic membrane
is_a: GO:0097458 ! neuron part
relationship: part_of GO:0042734 ! presynaptic membrane
created_by: rfoulger
creation_date: 2011-12-14T02:25:29Z

[Term]
id: GO:0036063
name: acroblast
namespace: cellular_component
def: "A cone-shaped structure in the head of a spermatozoon, which is formed by the coalescence of Golgi fragments following the completion of meiosis. The acroblast is situated adjacent to the acrosomal vesicle." [GOC:sart, PMID:19934220]
comment: See also the fly_anatomy.ontology term 'acroblast ; FBbt:00004947'.
synonym: "spermatid acroblast" EXACT [GOC:bf]
is_a: GO:0044431 ! Golgi apparatus part
created_by: rfoulger
creation_date: 2011-12-14T02:29:05Z

[Term]
id: GO:0036064
name: ciliary basal body
namespace: cellular_component
alt_id: GO:0005932
def: "A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]
comment: In most eukaryotic cells, 'ciliary basal body' (GO:0036064) and 'centriole' (GO:0005814) represent a common entity that cycles through its function in cell division, then ciliogenesis, then cell division again. However, these structures are modified extensively as they transition into each other, and may contain different proteins, specific to each component.
synonym: "basal body" BROAD []
synonym: "cilial basal body" EXACT []
synonym: "cilium basal body" EXACT [GOC:bf]
synonym: "microtubule basal body" EXACT []
xref: NIF_Subcellular:sao11978067
is_a: GO:0005815 ! microtubule organizing center
is_a: GO:0044441 ! ciliary part
intersection_of: GO:0005815 ! microtubule organizing center
intersection_of: part_of GO:0042995 ! cell projection
relationship: part_of GO:0042995 ! cell projection
created_by: rfoulger
creation_date: 2011-12-15T10:40:20Z

[Term]
id: GO:0036065
name: fucosylation
namespace: biological_process
def: "The covalent attachment of a fucosyl group to an acceptor molecule." [CHEBI:62688, GOC:sart, PMID:19948734]
is_a: GO:0070085 ! glycosylation
created_by: rfoulger
creation_date: 2011-12-15T11:16:19Z

[Term]
id: GO:0036066
name: protein O-linked fucosylation
namespace: biological_process
def: "The process of transferring a fucosyl group to a serine or threonine residues in a protein acceptor molecule, to form an O-linked protein-sugar linkage." [GOC:sart, PMID:19948734]
is_a: GO:0006493 ! protein O-linked glycosylation
is_a: GO:0036065 ! fucosylation
created_by: rfoulger
creation_date: 2011-12-15T11:17:20Z

[Term]
id: GO:0036067
name: light-dependent chlorophyll biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors, which occur in the presence of light." [GOC:yaf, PMID:12242396]
synonym: "light dependent chlorophyll biosynthetic process" EXACT [GOC:yaf]
synonym: "light-dependent chlorophyll anabolism" EXACT [GOC:bf]
synonym: "light-dependent chlorophyll biosynthesis" EXACT [GOC:bf]
synonym: "light-dependent chlorophyll formation" EXACT [GOC:bf]
synonym: "light-dependent chlorophyll synthesis" EXACT [GOC:bf]
is_a: GO:0015995 ! chlorophyll biosynthetic process
created_by: rfoulger
creation_date: 2011-12-15T04:42:47Z

[Term]
id: GO:0036068
name: light-independent chlorophyll biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors, which occur in the absence of light." [GOC:yaf, PMID:12242396, UniPathway:UPA00670]
synonym: "light independent chlorophyll biosynthetic process" EXACT [GOC:yaf]
synonym: "light-independent chlorophyll anabolism" EXACT [GOC:bf]
synonym: "light-independent chlorophyll biosynthesis" EXACT [GOC:bf]
synonym: "light-independent chlorophyll formation" EXACT [GOC:bf]
synonym: "light-independent chlorophyll synthesis" EXACT [GOC:bf]
is_a: GO:0015995 ! chlorophyll biosynthetic process
created_by: rfoulger
creation_date: 2011-12-15T04:44:18Z

[Term]
id: GO:0036069
name: light-dependent bacteriochlorophyll biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a bacteriochlorophyll, which occur in the presence of light. Bacteriochlorophylls are any of the chlorophylls of photosynthetic bacteria; they differ structurally from the chlorophylls of higher plants." [GOC:yaf, PMID:12242396]
subset: gosubset_prok
synonym: "light dependent bacteriochlorophyll biosynthetic process" EXACT [GOC:bf]
synonym: "light-dependent bacteriochlorophyll anabolism" EXACT [GOC:bf]
synonym: "light-dependent bacteriochlorophyll biosynthesis" EXACT [GOC:bf]
synonym: "light-dependent bacteriochlorophyll formation" EXACT [GOC:bf]
synonym: "light-dependent bacteriochlorophyll synthesis" EXACT [GOC:bf]
is_a: GO:0030494 ! bacteriochlorophyll biosynthetic process
is_a: GO:0036067 ! light-dependent chlorophyll biosynthetic process
created_by: rfoulger
creation_date: 2011-12-15T04:45:16Z

[Term]
id: GO:0036070
name: light-independent bacteriochlorophyll biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a bacteriochlorophyll, which occur in the absence of light. Bacteriochlorophylls are any of the chlorophylls of photosynthetic bacteria; they differ structurally from the chlorophylls of higher plants." [GOC:yaf, PMID:12242396, UniPathway:UPA00671]
subset: gosubset_prok
synonym: "light independent bacteriochlorophyll biosynthetic process" EXACT [GOC:bf]
synonym: "light-independent bacteriochlorophyll anabolism" EXACT [GOC:bf]
synonym: "light-independent bacteriochlorophyll biosynthesis" EXACT [GOC:bf]
synonym: "light-independent bacteriochlorophyll formation" EXACT [GOC:bf]
synonym: "light-independent bacteriochlorophyll synthesis" EXACT [GOC:bf]
is_a: GO:0030494 ! bacteriochlorophyll biosynthetic process
is_a: GO:0036068 ! light-independent chlorophyll biosynthetic process
created_by: rfoulger
creation_date: 2011-12-15T04:46:25Z

[Term]
id: GO:0036071
name: N-glycan fucosylation
namespace: biological_process
def: "The process of transferring a fucosyl group to an N-glycan. An N-glycan is the carbohydrate portion of an N-glycoprotein when attached to a nitrogen from asparagine or arginine side-chains." [CHEBI:59520, GOC:sart, PMID:19948734]
synonym: "glycoprotein fucosylation" RELATED [GOC:bf]
is_a: GO:0036065 ! fucosylation
created_by: rfoulger
creation_date: 2011-12-15T04:54:24Z

[Term]
id: GO:0036072
name: direct ossification
namespace: biological_process
def: "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance, that does not require the replacement of preexisting tissues." [GO_REF:0000034]
is_a: GO:0001503 ! ossification
created_by: rfoulger
creation_date: 2011-12-19T01:47:22Z

[Term]
id: GO:0036073
name: perichondral ossification
namespace: biological_process
def: "Intramembranous ossification from the surface of a cartilage element as the perichondrium becomes a periosteum, without replacement of cartilage." [GO_REF:0000034]
is_a: GO:0001957 ! intramembranous ossification
created_by: rfoulger
creation_date: 2011-12-19T01:49:38Z

[Term]
id: GO:0036074
name: metaplastic ossification
namespace: biological_process
def: "Direct ossification in which bone formation occurs as result of the direct transformation of non-bone cells into bone cells without cell division." [GO_REF:0000034]
comment: Some intramembranous ossification may also be classified as metaplastic; the former classifies based on tissue type location, and the latter based on mechanism/cell division.
synonym: "metaplasia" RELATED [GO_REF:0000034]
is_a: GO:0036072 ! direct ossification
created_by: rfoulger
creation_date: 2011-12-19T01:50:35Z

[Term]
id: GO:0036075
name: replacement ossification
namespace: biological_process
def: "Ossification that requires the replacement of a preexisting tissue prior to bone tissue formation." [GO_REF:0000034]
synonym: "indirect ossification" EXACT [GO_REF:0000034]
is_a: GO:0001503 ! ossification
created_by: rfoulger
creation_date: 2011-12-19T01:53:16Z

[Term]
id: GO:0036076
name: ligamentous ossification
namespace: biological_process
def: "Ossification wherein bone tissue forms within ligamentous tissue." [GO_REF:0000034]
comment: Ligamentous ossification may occur via replacement ossification or metaplastic ossification or both in any one instance.
is_a: GO:0001503 ! ossification
created_by: rfoulger
creation_date: 2011-12-19T01:57:08Z

[Term]
id: GO:0036077
name: intratendonous ossification
namespace: biological_process
def: "Ossification wherein bone tissue forms within tendonous tissue." [GO_REF:0000034]
comment: Tendonous ossification may occur via replacement ossification or metaplastic ossification or both in any one instance.
is_a: GO:0001503 ! ossification
created_by: rfoulger
creation_date: 2011-12-19T01:57:48Z

[Term]
id: GO:0036078
name: minus-end specific microtubule depolymerization
namespace: biological_process
def: "The removal of tubulin heterodimers from the minus end of a microtubule." [GOC:sart, PMID:17452528]
is_a: GO:0007019 ! microtubule depolymerization
created_by: rfoulger
creation_date: 2011-12-19T03:20:25Z

[Term]
id: GO:0036079
name: purine nucleotide-sugar transport
namespace: biological_process
def: "The directed movement of a purine nucleotide-sugar into, out of or within a cell. Purine nucleotide-sugars are purine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:sart, PMID:19948734]
is_a: GO:0015780 ! nucleotide-sugar transport
created_by: rfoulger
creation_date: 2011-12-19T03:22:58Z

[Term]
id: GO:0036080
name: purine nucleotide-sugar transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a purine nucleotide-sugar from one side of the membrane to the other. Purine nucleotide-sugars are purine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:sart, PMID:19948734]
is_a: GO:0005338 ! nucleotide-sugar transmembrane transporter activity
relationship: part_of GO:0090480 ! purine nucleotide-sugar transmembrane transport
created_by: rfoulger
creation_date: 2011-12-19T03:29:06Z

[Term]
id: GO:0036081
name: extracellular ammonia-gated ion channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of an ion by a channel that opens when extracellular ammonia (NH3) has been bound by the channel complex or one of its constituent parts." [GOC:sart, PMID:19135896]
synonym: "ionotropic ammonia receptor activity" RELATED [PMID:19135896]
is_a: GO:0005230 ! extracellular ligand-gated ion channel activity
created_by: rfoulger
creation_date: 2011-12-20T04:47:48Z

[Term]
id: GO:0036082
name: extracellular phenylacetaldehyde-gated ion channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of an ion by a channel that opens when extracellular phenylacetaldehyde has been bound by the channel complex or one of its constituent parts." [GOC:sart, PMID:19135896]
synonym: "ionotropic phenylacetaldehyde receptor activity" RELATED [PMID:19135896]
is_a: GO:0005230 ! extracellular ligand-gated ion channel activity
created_by: rfoulger
creation_date: 2011-12-20T04:49:31Z

[Term]
id: GO:0036083
name: positive regulation of unsaturated fatty acid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of unsaturated fatty acid biosynthetic process by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:9927444]
is_a: GO:0072366 ! regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter
is_a: GO:2000531 ! regulation of fatty acid biosynthetic process by regulation of transcription from RNA polymerase II promoter
is_a: GO:2001280 ! positive regulation of unsaturated fatty acid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: positively_regulates GO:0006636 ! unsaturated fatty acid biosynthetic process
relationship: positively_regulates GO:0006366 ! transcription from RNA polymerase II promoter
relationship: positively_regulates GO:0006636 ! unsaturated fatty acid biosynthetic process
created_by: rfoulger
creation_date: 2011-12-20T04:52:36Z

[Term]
id: GO:0036084
name: GDP-fucose import into endoplasmic reticulum lumen
namespace: biological_process
def: "The directed movement of GDP-fucose into the endoplasmic reticulum lumen. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate." [GOC:sart, PMID:3458237]
synonym: "GDP-fucose import into endoplasmic reticulum" EXACT [GOC:bf]
synonym: "GDP-fucose transport across endoplasmic reticulum membrane" EXACT [GOC:bf]
synonym: "GDP-fucose transport into endoplasmic reticulum lumen" EXACT [GOC:sart]
is_a: GO:0015783 ! GDP-fucose transport
is_a: GO:0090480 ! purine nucleotide-sugar transmembrane transport
is_a: GO:1902582 ! single-organism intracellular transport
relationship: occurs_in GO:0005737 ! cytoplasm
created_by: rfoulger
creation_date: 2011-12-21T01:45:11Z

[Term]
id: GO:0036085
name: GDP-fucose import into Golgi lumen
namespace: biological_process
def: "The directed movement of GDP-fucose into the Golgi lumen. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate." [GOC:sart, PMID:3458237]
synonym: "GDP-fucose import into Golgi" EXACT [GOC:bf]
synonym: "GDP-fucose transport across Golgi membrane" EXACT [GOC:bf]
synonym: "GDP-fucose transport into Golgi lumen" EXACT [GOC:sart]
is_a: GO:0015783 ! GDP-fucose transport
is_a: GO:0090480 ! purine nucleotide-sugar transmembrane transport
is_a: GO:1902582 ! single-organism intracellular transport
relationship: occurs_in GO:0005737 ! cytoplasm
created_by: rfoulger
creation_date: 2011-12-21T01:52:10Z

[Term]
id: GO:0036086
name: positive regulation of transcription from RNA polymerase II promoter in response to iron ion starvation
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of iron ions." [GOC:cjk]
synonym: "positive regulation of transcription from RNA polymerase II promoter in response to iron deficiency" EXACT [GOC:bf]
is_a: GO:0033217 ! regulation of transcription from RNA polymerase II promoter in response to iron ion starvation
is_a: GO:0036003 ! positive regulation of transcription from RNA polymerase II promoter in response to stress
created_by: rfoulger
creation_date: 2012-01-05T01:45:26Z

[Term]
id: GO:0036087
name: glutathione synthase complex
namespace: cellular_component
def: "A protein complex composed of two or more polypeptide subunits, and which possesses glutathione synthase activity (catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H(+) + phosphate). In eukaryotes, the complex is homodimeric, in E. coli glutathione synthase exists as a tetramer, and in S. pombe the complex exists as a homodimer or a heterotetramer." [GOC:al, PMID:12734194, PMID:14990577, PMID:1958212]
synonym: "glutathione synthetase complex" EXACT [PMID:12734194, PMID:14990577, PMID:1958212]
is_a: GO:1902494 ! catalytic complex
created_by: rfoulger
creation_date: 2012-01-05T04:29:20Z

[Term]
id: GO:0036088
name: D-serine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-serine, the D-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [CHEBI:16523, GOC:imk]
synonym: "D-serine breakdown" EXACT [GOC:bf]
synonym: "D-serine catabolism" EXACT [GOC:bf]
synonym: "D-serine degradation" EXACT [GOC:bf]
is_a: GO:0009071 ! serine family amino acid catabolic process
is_a: GO:0019478 ! D-amino acid catabolic process
is_a: GO:0070178 ! D-serine metabolic process
created_by: rfoulger
creation_date: 2012-01-06T10:58:51Z

[Term]
id: GO:0036089
name: cleavage furrow formation
namespace: biological_process
def: "Generation of the cleavage furrow, a shallow groove in the cell surface near the old metaphase plate that marks the site of cytokinesis. This process includes the recruitment and localized activation of signals such as RhoA at the site of the future furrow to ensure that furrowing initiates at the correct site in the cell." [GOC:ans, PMID:15811947, PMID:20687468, PMID:2192590]
comment: Consider also annotating to 'establishment of contractile ring localization involved in cell cycle cytokinesis ; GO:0032188'.
synonym: "cleavage furrow positioning" NARROW [PMID:14757750]
is_a: GO:0032506 ! cytokinetic process
relationship: part_of GO:0061640 ! cytoskeleton-dependent cytokinesis
created_by: rfoulger
creation_date: 2012-01-10T02:41:03Z

[Term]
id: GO:0036090
name: cleavage furrow ingression
namespace: biological_process
def: "Advancement of the cleavage furrow from the outside of the cell inward towards the center of the cell. The cleavage furrow acts as a 'purse string' which draws tight to separate daughter cells during cytokinesis and partition the cytoplasm between the two daughter cells. The furrow ingresses until a cytoplasmic bridge is formed." [PMID:15811947, PMID:20687468]
comment: Consider also annotating to 'contractile ring contraction involved in cell cycle cytokinesis ; GO:0000916'.
synonym: "cleavage furrow contraction" EXACT [PMID:3413069]
is_a: GO:0032506 ! cytokinetic process
relationship: part_of GO:0061640 ! cytoskeleton-dependent cytokinesis
created_by: rfoulger
creation_date: 2012-01-10T02:46:05Z

[Term]
id: GO:0036091
name: positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:rn, PMID:14978214, PMID:18439143]
is_a: GO:0036003 ! positive regulation of transcription from RNA polymerase II promoter in response to stress
is_a: GO:0043619 ! regulation of transcription from RNA polymerase II promoter in response to oxidative stress
is_a: GO:1901522 ! positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
created_by: rfoulger
creation_date: 2012-01-10T02:54:43Z

[Term]
id: GO:0036092
name: phosphatidylinositol-3-phosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phosphatidylinositol-3-phosphate, a phosphatidylinositol monophosphate carrying the phosphate group at the 3-position." [CHEBI:26034, GOC:al, GOC:vw]
synonym: "phosphatidylinositol-3-phosphate anabolism" EXACT [GOC:bf]
synonym: "phosphatidylinositol-3-phosphate biosynthesis" EXACT [GOC:bf]
synonym: "phosphatidylinositol-3-phosphate formation" EXACT [GOC:bf]
synonym: "phosphatidylinositol-3-phosphate synthesis" EXACT [GOC:bf]
synonym: "PI(3)P biosynthesis" EXACT [CHEBI:26034]
synonym: "PtdIns3P biosynthesis" EXACT [CHEBI:26034]
is_a: GO:0006661 ! phosphatidylinositol biosynthetic process
created_by: rfoulger
creation_date: 2012-01-13T02:13:57Z

[Term]
id: GO:0036093
name: germ cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of germ cells, reproductive cells in multicellular organisms, resulting in the expansion of a cell population." [CL:0000586, GOC:kmv]
is_a: GO:0008283 ! cell proliferation
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
relationship: part_of GO:0007276 ! gamete generation
created_by: rfoulger
creation_date: 2012-01-17T04:06:27Z

[Term]
id: GO:0036094
name: small molecule binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a small molecule, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:pm]
comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides.
is_a: GO:0005488 ! binding
created_by: rfoulger
creation_date: 2012-01-17T04:20:34Z

[Term]
id: GO:0036095
name: positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of invasive growth as a result of deprivation of glucose, by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:jh, PMID:14668363]
synonym: "transcriptional activation of genes involved in invasive growth" RELATED [GOC:bf]
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
is_a: GO:2000219 ! positive regulation of invasive growth in response to glucose limitation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001403 ! invasive growth in response to glucose limitation
intersection_of: positively_regulates GO:0006357 ! regulation of transcription from RNA polymerase II promoter
relationship: positively_regulates GO:0001403 ! invasive growth in response to glucose limitation
relationship: positively_regulates GO:0006357 ! regulation of transcription from RNA polymerase II promoter
created_by: rfoulger
creation_date: 2012-01-24T10:53:28Z

[Term]
id: GO:0036096
name: obsolete 3'-5'-exoribonuclease activity involved in pre-miRNA 3'-end processing
namespace: molecular_function
def: "OBSOLETE. Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule that contributes to forming the mature 3' end of a miRNA from a pre-miRNA." [GOC:sart, PMID:22055292]
comment: This term was made obsolete because it is not real a process, and was created accidentally.
synonym: "3'-5'-exoribonuclease activity involved in pre-miRNA 3'-end processing" EXACT []
synonym: "exonucleolytic trimming to generate 3' end of miRNA from pre-miRNA" RELATED [GOC:sart]
is_obsolete: true
created_by: rfoulger
creation_date: 2012-01-24T02:29:03Z

[Term]
id: GO:0036097
name: obsolete pre-miRNA 3'-end processing
namespace: biological_process
def: "OBSOLETE. Any process involved in forming the mature 3' end of a miRNA from a pre-miRNA." [GOC:sart, PMID:22055292]
comment: This term was made obsolete because it is not real a process, and was created accidentally.
synonym: "microRNA 3'-end processing" BROAD [PMID:22055292]
synonym: "miRNA 3'-end processing" BROAD [PMID:22055292]
synonym: "pre-miRNA 3'-end processing" EXACT []
is_obsolete: true
created_by: rfoulger
creation_date: 2012-01-24T02:31:37Z

[Term]
id: GO:0036098
name: male germ-line stem cell population maintenance
namespace: biological_process
def: "The process by which an organism or tissue maintains a population of male germ-line stem cells." [GOC:sart, PMID:21752937]
is_a: GO:0030718 ! germ-line stem cell population maintenance
created_by: rfoulger
creation_date: 2012-01-26T01:58:10Z

[Term]
id: GO:0036099
name: female germ-line stem cell population maintenance
namespace: biological_process
def: "The process by which an organism or tissue maintains a population of female germ-line stem cells." [GOC:sart]
is_a: GO:0030718 ! germ-line stem cell population maintenance
created_by: rfoulger
creation_date: 2012-01-26T01:58:10Z

[Term]
id: GO:0036100
name: leukotriene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid." [CHEBI:62942, GOC:yaf]
synonym: "leukotriene breakdown" EXACT [GOC:bf]
synonym: "leukotriene catabolism" EXACT [GOC:bf]
synonym: "leukotriene degradation" EXACT [GOC:bf]
is_a: GO:0006691 ! leukotriene metabolic process
is_a: GO:0009062 ! fatty acid catabolic process
is_a: GO:1901523 ! icosanoid catabolic process
created_by: rfoulger
creation_date: 2012-01-27T01:26:24Z

[Term]
id: GO:0036101
name: leukotriene B4 catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of leukotriene B4, a leukotriene composed of (6Z,8E,10E,14Z)-eicosatetraenoic acid having (5S)- and (12R)-hydroxy substituents." [CHEBI:15647, GOC:yaf, PMID:9799565, UniPathway:UPA00883]
synonym: "leukotriene B4 breakdown" EXACT [GOC:bf]
synonym: "leukotriene B4 catabolism" EXACT [GOC:bf]
synonym: "leukotriene B4 degradation" EXACT [GOC:bf]
synonym: "LTB4 catabolism" EXACT [CHEBI:15647]
is_a: GO:0036100 ! leukotriene catabolic process
is_a: GO:0036102 ! leukotriene B4 metabolic process
is_a: GO:0042758 ! long-chain fatty acid catabolic process
is_a: GO:1901616 ! organic hydroxy compound catabolic process
created_by: rfoulger
creation_date: 2012-01-27T01:26:24Z

[Term]
id: GO:0036102
name: leukotriene B4 metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving leukotriene B4, a leukotriene composed of (6Z,8E,10E,14Z)-eicosatetraenoic acid having (5S)- and (12R)-hydroxy substituents." [CHEBI:15647, GOC:bf]
synonym: "LTB4 metabolism" EXACT [CHEBI:15647]
is_a: GO:0001676 ! long-chain fatty acid metabolic process
is_a: GO:0006691 ! leukotriene metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process
created_by: rfoulger
creation_date: 2012-01-27T01:39:43Z

[Term]
id: GO:0036103
name: Kdo2-lipid A metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving Kdo2-lipid A, a lipopolysaccharide (LPS) component." [CHEBI:27963, GOC:bf]
synonym: "Kdo2-lipid A metabolism" EXACT [GOC:bf]
is_a: GO:0006644 ! phospholipid metabolic process
is_a: GO:0006664 ! glycolipid metabolic process
is_a: GO:0043648 ! dicarboxylic acid metabolic process
is_a: GO:1901269 ! lipooligosaccharide metabolic process
created_by: rfoulger
creation_date: 2012-01-27T01:49:16Z

[Term]
id: GO:0036104
name: Kdo2-lipid A biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of Kdo2-lipid A, a lipopolysaccharide (LPS) component." [GOC:yaf, UniPathway:UPA00360]
synonym: "di[3-deoxy-D-manno-octulosonyl]-lipid A biosynthesis" EXACT [UniPathway:UPA00360]
synonym: "KDO(2)-lipid A biosynthesis" EXACT [UniPathway:UPA00360]
synonym: "Kdo2-lipid A anabolism" EXACT [GOC:bf]
synonym: "Kdo2-lipid A biosynthesis" EXACT [GOC:bf]
synonym: "Kdo2-lipid A formation" EXACT [GOC:bf]
synonym: "Kdo2-lipid A synthesis" EXACT [GOC:bf]
is_a: GO:0008654 ! phospholipid biosynthetic process
is_a: GO:0009247 ! glycolipid biosynthetic process
is_a: GO:0036103 ! Kdo2-lipid A metabolic process
is_a: GO:0043650 ! dicarboxylic acid biosynthetic process
is_a: GO:1901271 ! lipooligosaccharide biosynthetic process
created_by: rfoulger
creation_date: 2012-01-27T01:49:23Z

[Term]
id: GO:0036105
name: peroxisome membrane class-1 targeting sequence binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a class I peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane in a PEX19-dependent manner." [GOC:pm, PMID:14709540, PMID:17020786]
comment: Currently identified mPTSs vary greatly in length, and cannot be distinguished by primary structure analysis, suggesting that the peroxisomal sorting information is not contained within a specific amino acid sequence. There do however appear to be two classes of mPTSs: class 1 mPTSs that are bound by PEX19 and imported in a PEX19-dependent manner, and class 2 mPTSs that are not bound by PEX19 and mediate protein import independently of PEX19. The two classes cannot be defined based on their amino acid sequence.
synonym: "class 1 mPTS binding" EXACT [PMID:14709540]
synonym: "PEX19-dependent mPTS binding" RELATED [PMID:14709540]
is_a: GO:0033328 ! peroxisome membrane targeting sequence binding
created_by: rfoulger
creation_date: 2012-01-27T02:02:22Z

[Term]
id: GO:0036106
name: peroxisome membrane class-2 targeting sequence binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a class II peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane in a PEX19-independent manner." [GOC:pm, PMID:14709540, PMID:17020786]
comment: Currently identified mPTSs vary greatly in length, and cannot be distinguished by primary structure analysis, suggesting that the peroxisomal sorting information is not contained within a specific amino acid sequence. There do however appear to be two classes of mPTSs: class 1 mPTSs that are bound by PEX19 and imported in a PEX19-dependent manner, and class 2 mPTSs that are not bound by PEX19 and mediate protein import independently of PEX19. The two classes cannot be defined based on their amino acid sequence.
synonym: "class 2 mPTS binding" EXACT [PMID:14709540]
synonym: "PEX19-independent mPTS binding" RELATED [PMID:14709540]
is_a: GO:0033328 ! peroxisome membrane targeting sequence binding
created_by: rfoulger
creation_date: 2012-01-27T02:02:22Z

[Term]
id: GO:0036107
name: 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate, a precursor of 4-amino-4-deoxy-L-arabinose (L-Ara4N)." [CHEBI:47039, GOC:yaf]
synonym: "4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate metabolic process" EXACT [GOC:yaf]
synonym: "undecaprenyl phosphate alpha-L-Ara4N metabolism" EXACT [CHEBI:47039]
is_a: GO:0006644 ! phospholipid metabolic process
is_a: GO:0006664 ! glycolipid metabolic process
is_a: GO:0006721 ! terpenoid metabolic process
created_by: rfoulger
creation_date: 2012-02-06T02:55:42Z

[Term]
id: GO:0036108
name: 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate, a precursor of 4-amino-4-deoxy-L-arabinose (L-Ara4N)." [CHEBI:47039, GOC:yaf, UniPathway:UPA00036]
synonym: "4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate anabolism" EXACT [GOC:bf]
synonym: "4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthesis" EXACT [GOC:bf]
synonym: "4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate formation" EXACT [GOC:bf]
synonym: "4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate synthesis" EXACT [GOC:bf]
synonym: "undecaprenyl phosphate alpha-L-Ara4N biosynthesis" EXACT [CHEBI:47039]
is_a: GO:0008654 ! phospholipid biosynthetic process
is_a: GO:0009247 ! glycolipid biosynthetic process
is_a: GO:0016114 ! terpenoid biosynthetic process
is_a: GO:0036107 ! 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate metabolic process
created_by: rfoulger
creation_date: 2012-02-06T02:58:03Z

[Term]
id: GO:0036109
name: alpha-linolenic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving alpha-linolenic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2." [CHEBI:32387]
synonym: "ALA metabolism" EXACT [CHEBI:27432]
synonym: "alpha-linolenic acid metabolism" EXACT [GOC:bf]
xref: Wikipedia:Linoleic_acid
is_a: GO:0001676 ! long-chain fatty acid metabolic process
is_a: GO:0033559 ! unsaturated fatty acid metabolic process
created_by: rfoulger
creation_date: 2012-02-15T10:16:42Z

[Term]
id: GO:0036110
name: cellular response to inositol starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of inositol." [CHEBI:24848, GOC:al, PMID:19606215]
is_a: GO:0009267 ! cellular response to starvation
created_by: rfoulger
creation_date: 2012-02-15T10:46:07Z

[Term]
id: GO:0036111
name: very long-chain fatty-acyl-CoA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving very long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A very long-chain fatty acid is a fatty acid which has a chain length greater than C22." [CHEBI:61910, GOC:pm]
synonym: "very long-chain fatty acyl CoA metabolic process" EXACT [GOC:bf]
synonym: "very long-chain fatty acyl-CoA metabolism" EXACT [GOC:bf]
is_a: GO:0035337 ! fatty-acyl-CoA metabolic process
created_by: rfoulger
creation_date: 2012-02-15T11:09:22Z

[Term]
id: GO:0036112
name: medium-chain fatty-acyl-CoA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving medium-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A medium-chain fatty acid is a fatty acid with a chain length of between C6 and C12." [CHEBI:61907, GOC:pm]
synonym: "medium-chain fatty acyl CoA metabolic process" EXACT [GOC:bf]
synonym: "medium-chain fatty acyl-CoA metabolism" EXACT [GOC:bf]
is_a: GO:0035337 ! fatty-acyl-CoA metabolic process
created_by: rfoulger
creation_date: 2012-02-15T11:12:19Z

[Term]
id: GO:0036113
name: very long-chain fatty-acyl-CoA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of very long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A very long-chain fatty acid is a fatty acid which has a chain length greater than C22." [CHEBI:61910, GOC:pm]
synonym: "very long-chain fatty-acyl-CoA breakdown" EXACT [GOC:bf]
synonym: "very long-chain fatty-acyl-CoA catabolism" EXACT [GOC:bf]
synonym: "very long-chain fatty-acyl-CoA degradation" EXACT [GOC:bf]
is_a: GO:0036111 ! very long-chain fatty-acyl-CoA metabolic process
is_a: GO:0036115 ! fatty-acyl-CoA catabolic process
created_by: rfoulger
creation_date: 2012-02-15T11:16:11Z

[Term]
id: GO:0036114
name: medium-chain fatty-acyl-CoA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of medium-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A medium-chain fatty acid is a fatty acid with a chain length of between C6 and C12." [CHEBI:61907, GOC:pm]
synonym: "medium-chain fatty-acyl-CoA breakdown" EXACT [GOC:bf]
synonym: "medium-chain fatty-acyl-CoA catabolism" EXACT [GOC:bf]
synonym: "medium-chain fatty-acyl-CoA degradation" EXACT [GOC:bf]
is_a: GO:0036112 ! medium-chain fatty-acyl-CoA metabolic process
is_a: GO:0036115 ! fatty-acyl-CoA catabolic process
created_by: rfoulger
creation_date: 2012-02-15T11:23:16Z

[Term]
id: GO:0036115
name: fatty-acyl-CoA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group." [CHEBI:37554]
synonym: "fatty-acyl-CoA breakdown" EXACT [GOC:bf]
synonym: "fatty-acyl-CoA catabolism" EXACT [GOC:bf]
synonym: "fatty-acyl-CoA degradation" EXACT [GOC:bf]
is_a: GO:0009109 ! coenzyme catabolic process
is_a: GO:0035337 ! fatty-acyl-CoA metabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:1901575 ! organic substance catabolic process
created_by: rfoulger
creation_date: 2012-02-15T11:26:25Z

[Term]
id: GO:0036116
name: long-chain fatty-acyl-CoA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [CHEBI:33184, GOC:pm]
synonym: "long-chain fatty-acyl-CoA breakdown" EXACT [GOC:bf]
synonym: "long-chain fatty-acyl-CoA catabolism" EXACT [GOC:bf]
synonym: "long-chain fatty-acyl-CoA degradation" EXACT [GOC:bf]
is_a: GO:0035336 ! long-chain fatty-acyl-CoA metabolic process
is_a: GO:0036115 ! fatty-acyl-CoA catabolic process
created_by: rfoulger
creation_date: 2012-02-15T11:30:24Z

[Term]
id: GO:0036117
name: hyaluranon cable
namespace: cellular_component
def: "A cable structure, surrounding some cell types (e.g. proximal or bronchial tubular epithelial cells), and composed of hyaluranon (HA), a ubiquitous connective tissue glycosaminoglycan." [GOC:yaf, PMID:16900089]
synonym: "HA cable" EXACT [PMID:16900089]
is_a: GO:0044421 ! extracellular region part
created_by: rfoulger
creation_date: 2012-02-16T10:53:37Z

[Term]
id: GO:0036118
name: hyaluranon cable assembly
namespace: biological_process
def: "A process that results in the aggregation, arrangement and bonding together of a hyaluranon cable, a cable structure, surrounding some cell types (e.g. proximal or bronchial tubular epithelial cells), and composed of hyaluranon (HA), a ubiquitous connective tissue glycosaminoglycan." [GOC:yaf, PMID:16900089]
synonym: "HA cable assembly" EXACT [PMID:16900089]
is_a: GO:0022607 ! cellular component assembly
created_by: rfoulger
creation_date: 2012-02-16T11:06:58Z

[Term]
id: GO:0036119
name: response to platelet-derived growth factor
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet-derived growth factor stimulus." [GOC:yaf]
synonym: "response to PDGF stimulus" EXACT [GOC:bf]
synonym: "response to platelet-derived growth factor stimulus" EXACT [GOC:dos]
is_a: GO:0009719 ! response to endogenous stimulus
is_a: GO:0070848 ! response to growth factor
created_by: rfoulger
creation_date: 2012-02-20T02:48:00Z

[Term]
id: GO:0036120
name: cellular response to platelet-derived growth factor stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet-derived growth factor stimulus." [GOC:yaf]
synonym: "cellular response to PDGF stimulus" EXACT [GOC:bf]
is_a: GO:0036119 ! response to platelet-derived growth factor
is_a: GO:0071363 ! cellular response to growth factor stimulus
is_a: GO:0071495 ! cellular response to endogenous stimulus
created_by: rfoulger
creation_date: 2012-02-20T02:49:02Z

[Term]
id: GO:0036121
name: double-stranded DNA-dependent ATP-dependent DNA helicase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of double-stranded DNA; drives the unwinding of a DNA helix." [GOC:kmv]
synonym: "dsDNA-dependent ATP-dependent DNA helicase activity" EXACT [GOC:kmv]
is_a: GO:0004003 ! ATP-dependent DNA helicase activity
is_a: GO:0033676 ! double-stranded DNA-dependent ATPase activity
created_by: rfoulger
creation_date: 2012-02-20T02:53:51Z

[Term]
id: GO:0036122
name: BMP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a member of the bone morphogenetic protein (BMP) family." [GOC:BHF, PMID:9660951, PR:000000034]
synonym: "bone morphogenetic protein binding" EXACT [GOC:bf]
is_a: GO:0019955 ! cytokine binding
created_by: rfoulger
creation_date: 2012-02-20T02:59:34Z

[Term]
id: GO:0036123
name: histone H3-K9 dimethylation
namespace: biological_process
def: "The modification of histone H3 by addition of two methyl groups to lysine at position 9 of the histone." [GOC:vw]
synonym: "histone H3 K9 dimethylation" EXACT []
synonym: "histone lysine H3 K9 dimethylation" EXACT []
is_a: GO:0018027 ! peptidyl-lysine dimethylation
is_a: GO:0051567 ! histone H3-K9 methylation
created_by: rfoulger
creation_date: 2012-02-20T03:06:15Z

[Term]
id: GO:0036124
name: histone H3-K9 trimethylation
namespace: biological_process
def: "The modification of histone H3 by addition of three methyl groups to lysine at position 9 of the histone." [GOC:vw]
is_a: GO:0018023 ! peptidyl-lysine trimethylation
is_a: GO:0051567 ! histone H3-K9 methylation
created_by: rfoulger
creation_date: 2012-02-20T03:08:06Z

[Term]
id: GO:0036125
name: fatty acid beta-oxidation multienzyme complex
namespace: cellular_component
def: "A multienzyme complex possessing three kinds of enzymes that catalyze the chain reactions in the fatty acid beta-oxidation cycle, enoyl-CoA hydratase (ECH), 3-hydroxyacyl-CoA dehydrogenase (HACD), and acetyl-CoA C-acyltransferase (KACT)." [GOC:imk, PMID:12115060, PMID:16472743]
comment: For fatty acid beta-oxidation multienzyme complexes located in the mitochondrial matrix, consider instead the term 'mitochondrial fatty acid beta-oxidation multienzyme complex ; GO:0016507'.
is_a: GO:0043234 ! protein complex
created_by: rfoulger
creation_date: 2012-02-28T02:10:39Z

[Term]
id: GO:0036126
name: sperm flagellum
namespace: cellular_component
def: "A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid." [GOC:cilia, GOC:sart, PMID:8441407]
comment: Note that cilia and eukaryotic flagella are deemed to be equivalent. In this case community usage is always 'flagellum', hence the primary term name, but the cilium parentage is deliberate.
synonym: "sperm cilium" EXACT []
synonym: "sperm tail" EXACT [GOC:sart]
is_a: GO:0031514 ! motile cilium
is_a: GO:0097223 ! sperm part
created_by: rfoulger
creation_date: 2012-02-28T02:39:00Z

[Term]
id: GO:0036127
name: 3-sulfino-L-alanine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with 3-sulfino-L-alanine (cysteine sulfinate)." [CHEBI:61085, GOC:al, PMID:8346915]
synonym: "cysteine sulfinate binding" EXACT [CHEBI:61085, GOC:al]
is_a: GO:0016597 ! amino acid binding
is_a: GO:0072341 ! modified amino acid binding
is_a: GO:1901681 ! sulfur compound binding
created_by: rfoulger
creation_date: 2012-02-28T03:15:40Z

[Term]
id: GO:0036128
name: CatSper complex
namespace: cellular_component
def: "A sperm-specific voltage-gated calcium channel that controls the intracellular calcium ion concentration and, thereby, the swimming behavior of sperm. Consists of a heteromeric tetramer surrounding a calcium ion- selective pore. May also contain additional auxiliary subunits." [GOC:sp, PMID:17478420, PMID:21224844, PMID:22354039]
synonym: "CATSPER channel" EXACT [PMID:21224844]
synonym: "CatSper channel complex" EXACT [PMID:17478420]
is_a: GO:0005891 ! voltage-gated calcium channel complex
created_by: rfoulger
creation_date: 2012-03-02T10:26:48Z

[Term]
id: GO:0036129
name: negative regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hydrogen peroxide (H2O2) stimulus." [GOC:al]
is_a: GO:0061417 ! negative regulation of transcription from RNA polymerase II promoter in response to oxidative stress
relationship: part_of GO:0070301 ! cellular response to hydrogen peroxide
created_by: rfoulger
creation_date: 2012-03-02T10:36:39Z

[Term]
id: GO:0036130
name: prostaglandin H2 endoperoxidase reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: prostaglandin H2 + NADPH + H+ -> prostaglandin F2alpha + NADP+. This reaction is the reduction of prostaglandin H2 ((5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-5,13-dienoate) to prostaglandin F2alpha ((5Z,13E)-(15S)-9alpha,11alpha,15-Trihydroxyprosta-5,13-dienoate)." [GOC:mw, KEGG:R02264, PMID:10622721, PMID:14979715, PMID:16475787]
synonym: "PGH2 9,11-endoperoxidase" EXACT [PMID:12664595]
synonym: "PGH2 9-,11-endoperoxide reductase" EXACT [PMID:12432932]
xref: KEGG:R02264
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
relationship: part_of GO:0006693 ! prostaglandin metabolic process
created_by: rfoulger
creation_date: 2012-03-05T09:25:03Z

[Term]
id: GO:0036131
name: prostaglandin D2 11-ketoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: prostaglandin D2 + H+ + NADPH -> 11-epi-prostaglandin F2alpha + NADP+." [EC:1.1.1.188, GOC:mw, KEGG:R02799, PMID:1504718, PMID:3862115]
synonym: "PGD2 11-ketoreductase" EXACT [PMID:14996743]
synonym: "prostaglandin 11-keto reductase" EXACT [PMID:7248318]
xref: EC:1.1.1.188
xref: KEGG:R02799
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
relationship: part_of GO:0006693 ! prostaglandin metabolic process
created_by: rfoulger
creation_date: 2012-03-05T10:27:29Z

[Term]
id: GO:0036132
name: 13-prostaglandin reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 15-keto-prostaglandin + NAD(P)H + H+ -> 13,14-dihydro-15-keto-prostaglandin + NAD(P)+. This reaction is the reduction of 15-keto-prostaglandin." [EC:1.3.1.48, GOC:mw, KEGG:R04556, KEGG:R04557, PMID:17449869]
comment: Note that this is the reverse of the reaction described in '15-oxoprostaglandin 13-oxidase activity ; GO:0047522'.
synonym: "15-ketoprostaglandin delta13-reductase activity" EXACT [EC:1.3.1.48]
synonym: "15-oxo-delta13-prostaglandin reductase activity" EXACT [EC:1.3.1.48]
synonym: "15-oxoprostaglandin 13-reductase activity" EXACT []
synonym: "delta13-15-ketoprostaglandin reductase activity" EXACT [EC:1.3.1.48]
synonym: "prostaglandin 13-reductase activity" EXACT [EC:1.3.1.48]
synonym: "prostaglandin delta13-reductase activity" EXACT [EC:1.3.1.48]
xref: EC:1.3.1.48
xref: KEGG:R04556
xref: KEGG:R04557
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
relationship: part_of GO:0006693 ! prostaglandin metabolic process
created_by: rfoulger
creation_date: 2012-03-05T10:42:22Z

[Term]
id: GO:0036133
name: 11-hydroxythromboxane B2 dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: thromboxane B2 + NAD+ = 11-dehydro-thromboxane B2 + NADH + H+." [GOC:mw, KEGG:R05060, PMID:3461463, PMID:3823488, PMID:8200461]
comment: Note that the KEGG:R05060 reaction does not stipulate the acceptor group, and is therefore slightly more general than the activity described by GO:0036133.
synonym: "NAD dependent 11-hydroxythromboxane B2 dehydrogenase activity" EXACT [PMID:1632314]
xref: KEGG:R05060
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
created_by: rfoulger
creation_date: 2012-03-05T11:05:09Z

[Term]
id: GO:0036134
name: 12-hydroxyheptadecatrienoic acid synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: prostaglandin H2 = 12-hydroxyheptadecatrienoic acid (HHT) + malonaldehyde (MDA)." [GOC:mw, PMID:11297515]
synonym: "prostaglandin H2 degradation activity" RELATED [GOC:mw]
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
created_by: rfoulger
creation_date: 2012-03-05T11:17:34Z

[Term]
id: GO:0036135
name: Schwann cell migration
namespace: biological_process
def: "The orderly movement of a Schwann cell from one site to another. A Schwann cell is a glial cell that ensheathes axons of neuron in the peripheral nervous system and is necessary for their maintainance and function." [CL:0002573, PMID:20335460]
is_a: GO:0008347 ! glial cell migration
created_by: rfoulger
creation_date: 2012-03-06T10:44:39Z

[Term]
id: GO:0036136
name: kynurenine-oxaloacetate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-aspartate." [EC:2.6.1.-, GOC:pde, PMID:15606768, PMID:4149765]
synonym: "L-kynurenine-oxaloacetate transaminase activity" EXACT [GOC:bf]
is_a: GO:0036137 ! kynurenine aminotransferase activity
created_by: rfoulger
creation_date: 2012-03-06T02:14:11Z

[Term]
id: GO:0036137
name: kynurenine aminotransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an amino group from kynurenine to an acceptor, usually a 2-oxo acid." [EC:2.6.1.-, GOC:pde]
synonym: "kynurenine-oxo-acid transaminase activity" NARROW [GOC:bf]
synonym: "L-kynurenine transaminase activity" EXACT [GOC:bf]
is_a: GO:0008483 ! transaminase activity
relationship: part_of GO:0097052 ! L-kynurenine metabolic process
created_by: rfoulger
creation_date: 2012-03-06T02:16:48Z

[Term]
id: GO:0036138
name: peptidyl-histidine hydroxylation
namespace: biological_process
def: "The hydroxylation of peptidyl-histidine to form peptidyl-hydroxyhistidine." [GOC:reh, PMID:21251231]
is_a: GO:0018126 ! protein hydroxylation
is_a: GO:0018202 ! peptidyl-histidine modification
created_by: rfoulger
creation_date: 2012-03-07T09:25:25Z

[Term]
id: GO:0036139
name: peptidyl-histidine dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: peptidyl L-histidine + 2-oxoglutarate + O2 = peptidyl hydroxy-L-histidine + succinate + CO2." [GOC:reh, PMID:21251231]
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
created_by: rfoulger
creation_date: 2012-03-07T09:26:54Z

[Term]
id: GO:0036140
name: peptidyl-asparagine 3-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: peptidyl L-asparagine + 2-oxoglutarate + O2 = peptidyl 3-hydroxy-L-asparagine + succinate + CO2." [GOC:reh, PMID:12215170]
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
created_by: rfoulger
creation_date: 2012-03-07T09:27:44Z

[Term]
id: GO:0036141
name: L-phenylalanine-oxaloacetate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction L-phenylalanine + oxaloacetate = phenylpyruvate + aspartate." [GOC:pde, PMID:15606768]
synonym: "L-phenylalanine:oxaloacetate transaminase activity" EXACT [GOC:bf]
is_a: GO:0070546 ! L-phenylalanine aminotransferase activity
created_by: rfoulger
creation_date: 2012-03-08T10:35:44Z

[Term]
id: GO:0036143
name: kringle domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a kringle domain. Kringle domains are protein domains that fold into large loops stabilized by 3 disulfide linkages, and are important in protein-protein interactions with blood coagulation factors." [GOC:yaf, InterPro:IPR000001, Wikipedia:Kringle_domain]
is_a: GO:0019904 ! protein domain specific binding
created_by: rfoulger
creation_date: 2012-03-09T09:49:43Z

[Term]
id: GO:0036145
name: dendritic cell homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of dendritic cells such that the total number of dendritic cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [CL:0000451, GOC:uh, PMID:12570827, PMID:19176316]
synonym: "DC homeostasis" RELATED [PMID:19176316]
is_a: GO:0001776 ! leukocyte homeostasis
created_by: rfoulger
creation_date: 2012-03-12T11:05:36Z

[Term]
id: GO:0036146
name: cellular response to mycotoxin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mycotoxin stimulus. A mycotoxin is a toxic chemical substance produced by fungi." [GOC:di, PMID:20548963]
is_a: GO:0010046 ! response to mycotoxin
is_a: GO:0097237 ! cellular response to toxic substance
created_by: rfoulger
creation_date: 2012-03-12T11:08:22Z

[Term]
id: GO:0036147
name: rumination
namespace: biological_process
def: "A digestive process in which food, usually grass or hay, is swallowed into a multi-compartmented stomach, regurgitated, chewed again, and swallowed again." [GOC:maf, Wikipedia:Rumination]
synonym: "digestive rumination" EXACT [Wikipedia:Rumination]
is_a: GO:0022600 ! digestive system process
created_by: rfoulger
creation_date: 2012-03-13T04:35:19Z

[Term]
id: GO:0036148
name: phosphatidylglycerol acyl-chain remodeling
namespace: biological_process
def: "Remodeling the acyl chains of phosphatidylglycerol, through sequential deacylation and re-acylation reactions, to generate phosphatidylglycerol containing different types of fatty acid acyl chains." [CHEBI:17517, GOC:mw, PMID:15485873, PMID:18458083]
is_a: GO:0046471 ! phosphatidylglycerol metabolic process
created_by: rfoulger
creation_date: 2012-03-14T01:14:23Z

[Term]
id: GO:0036149
name: phosphatidylinositol acyl-chain remodeling
namespace: biological_process
def: "Remodeling the acyl chains of phosphatidylinositol, through sequential deacylation and re-acylation reactions, to generate phosphatidylinositol containing different types of fatty acid acyl chains." [CHEBI:28874, GOC:mw, PMID:18094042, PMID:18772128]
is_a: GO:0046488 ! phosphatidylinositol metabolic process
created_by: rfoulger
creation_date: 2012-03-14T01:27:02Z

[Term]
id: GO:0036150
name: phosphatidylserine acyl-chain remodeling
namespace: biological_process
def: "Remodeling the acyl chains of phosphatidylserine, through sequential deacylation and re-acylation reactions, to generate phosphatidylserine containing different types of fatty acid acyl chains." [CHEBI:18303, GOC:mw, PMID:18287005, PMID:18458083]
synonym: "phosphatidyl-L-serine acyl-chain remodeling" NARROW [CHEBI:18303]
is_a: GO:0006658 ! phosphatidylserine metabolic process
created_by: rfoulger
creation_date: 2012-03-14T01:35:44Z

[Term]
id: GO:0036151
name: phosphatidylcholine acyl-chain remodeling
namespace: biological_process
def: "Remodeling the acyl chains of phosphatidylcholine, through sequential deacylation and re-acylation reactions, to generate phosphatidylcholine containing different types of fatty acid acyl chains." [CHEBI:49183, GOC:mw, PMID:18195019, PMID:18458083]
is_a: GO:0046470 ! phosphatidylcholine metabolic process
created_by: rfoulger
creation_date: 2012-03-14T01:54:13Z

[Term]
id: GO:0036152
name: phosphatidylethanolamine acyl-chain remodeling
namespace: biological_process
def: "Remodeling the acyl chains of phosphatidylethanolamine, through sequential deacylation and re-acylation reactions, to generate phosphatidylethanolamine containing different types of fatty acid acyl chains." [CHEBI:16038, GOC:mw, PMID:18287005, PMID:18458083]
is_a: GO:0046470 ! phosphatidylcholine metabolic process
created_by: rfoulger
creation_date: 2012-03-14T02:09:00Z

[Term]
id: GO:0036153
name: triglyceride acyl-chain remodeling
namespace: biological_process
def: "Remodeling the acyl chains of triacylglycerol, through sequential deacylation and re-acylation reactions, to generate triacylglycerol containing different types of fatty acid acyl chains." [CHEBI:17855, GOC:mw, PMID:15364929]
synonym: "triacylglycerol acyl-chain remodeling" EXACT [CHEBI:17855, GOC:mw, KEGG:C00422]
is_a: GO:0006641 ! triglyceride metabolic process
is_a: GO:0036155 ! acylglycerol acyl-chain remodeling
created_by: rfoulger
creation_date: 2012-03-14T02:49:05Z

[Term]
id: GO:0036154
name: diacylglycerol acyl-chain remodeling
namespace: biological_process
def: "Remodeling the acyl chains of diacylglycerol, through sequential deacylation and re-acylation reactions, to generate diacylglycerol containing different types of fatty acid acyl chains." [CHEBI:17855, GOC:mw, PMID:15364929]
synonym: "diglyceride acyl-chain remodeling" EXACT [CHEBI:18035, GOC:mw, KEGG:C00165]
is_a: GO:0036155 ! acylglycerol acyl-chain remodeling
is_a: GO:0046339 ! diacylglycerol metabolic process
created_by: rfoulger
creation_date: 2012-03-14T02:53:14Z

[Term]
id: GO:0036155
name: acylglycerol acyl-chain remodeling
namespace: biological_process
def: "Remodeling the acyl chains of an acylglycerol, through sequential deacylation and re-acylation reactions, to generate an acylglycerol containing different types of fatty acid acyl chains." [CHEBI:47778, GOC:mw, PMID:15364929]
synonym: "glyceride acyl-chain remodeling" EXACT [CHEBI:47778]
is_a: GO:0006639 ! acylglycerol metabolic process
created_by: rfoulger
creation_date: 2012-03-14T02:55:00Z

[Term]
id: GO:0036156
name: inner dynein arm
namespace: cellular_component
def: "Inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. The structure of inner dynein arms is complex and may vary within the axoneme. Inner dynein arms are heteromeric, comprising 8 different heavy chains and various subunits. Inner and outer dynein arms have different functions in the generation of microtubule-based motility." [GOC:BHF, GOC:vk, PMID:19347929, PMID:2557057, PMID:7962092]
synonym: "inner dynein arm complex" EXACT []
is_a: GO:0005858 ! axonemal dynein complex
created_by: rfoulger
creation_date: 2012-03-21T01:24:54Z

[Term]
id: GO:0036157
name: outer dynein arm
namespace: cellular_component
def: "Outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. Outer dynein arms contain 2-3 heavy chains, two or more intermediate chains and a cluster of 4-8 light chains. Inner and outer dynein arms have different functions in the generation of microtubule-based motility." [GOC:BHF, GOC:vk, PMID:2557057, PMID:6218174]
synonym: "outer dynein arm complex" EXACT []
is_a: GO:0005858 ! axonemal dynein complex
created_by: rfoulger
creation_date: 2012-03-21T01:25:03Z

[Term]
id: GO:0036158
name: outer dynein arm assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein outer arm, an outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes." [GOC:BHF, GOC:vk, PMID:19944400]
synonym: "ODA assembly" EXACT [PMID:19944400]
is_a: GO:0070286 ! axonemal dynein complex assembly
created_by: rfoulger
creation_date: 2012-03-21T02:25:01Z

[Term]
id: GO:0036159
name: inner dynein arm assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein inner arm, an inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes." [GOC:BHF, GOC:vk, PMID:19944400]
synonym: "IDA assembly" EXACT [PMID:19944400]
is_a: GO:0070286 ! axonemal dynein complex assembly
created_by: rfoulger
creation_date: 2012-03-21T02:25:01Z

[Term]
id: GO:0036160
name: melanocyte-stimulating hormone secretion
namespace: biological_process
def: "The regulated release of a melanocyte-stimulating hormone, any of a group of peptide hormones that are produced by cells in the intermediate lobe of the pituitary gland, and stimulate the production of melanin to increase pigmentation." [GOC:cjm, Wikipedia:Melanocyte-stimulating_hormone]
synonym: "MSH secretion" EXACT [GOC:cjm]
is_a: GO:0030072 ! peptide hormone secretion
created_by: rfoulger
creation_date: 2012-03-26T01:16:55Z

[Term]
id: GO:0036161
name: calcitonin secretion
namespace: biological_process
def: "The regulated release of calcitonin, a peptide hormone that participates in calcium and phosphorus metabolism, from a cell." [GOC:cjm, PR:000027222]
is_a: GO:0030072 ! peptide hormone secretion
created_by: rfoulger
creation_date: 2012-03-26T01:30:32Z

[Term]
id: GO:0036162
name: oxytocin secretion
namespace: biological_process
def: "The regulated release of oxytocin, a cyclic nonapeptide hormone with amino acid sequence CYIQNCPLG that also acts as a neurotransmitter in the brain, from a cell. Oxytocin is the principal uterine-contracting and milk-ejecting hormone of the posterior pituitary, and together with the neuropeptide vasopressin, is believed to influence social cognition and behavior." [CHEBI:7872, GOC:cjm, Wikipedia:Oxytocin]
is_a: GO:0030072 ! peptide hormone secretion
created_by: rfoulger
creation_date: 2012-03-26T01:43:46Z

[Term]
id: GO:0036163
name: 3-hexaprenyl-4-hydroxy-5-methoxybenzoic acid decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hexaprenyl-4-hydroxy-5-methoxybenzoic acid -> 2-hexaprenyl-6-methoxyphenol + CO2." [GOC:mw, KEGG:R06866, PMID:620805, PMID:7028108]
xref: KEGG:R06866
is_a: GO:0016831 ! carboxy-lyase activity
created_by: rfoulger
creation_date: 2012-03-26T01:49:54Z

[Term]
id: GO:0036164
name: cell-abiotic substrate adhesion
namespace: biological_process
def: "The attachment of a cell to an underlying abiotic (non-living) substrate via adhesion molecules." [GOC:di]
synonym: "cell-abiotic surface adhesion" RELATED [GOC:di]
is_a: GO:0031589 ! cell-substrate adhesion
created_by: rfoulger
creation_date: 2012-03-27T11:18:33Z

[Term]
id: GO:0036165
name: invasive growth in response to heat
namespace: biological_process
def: "The growth of colonies in filamentous chains of cells as a result of an increase in temperature." [GOC:di, PMID:22365851]
synonym: "invasive growth in response to elevated temperature" EXACT [PMID:22365851]
synonym: "invasive growth in response to high temperature" EXACT [PMID:22365851]
synonym: "invasive growth in response to temperature stimulus" BROAD [GOC:di]
is_a: GO:0036168 ! filamentous growth of a population of unicellular organisms in response to heat
is_a: GO:0036267 ! invasive filamentous growth
created_by: rfoulger
creation_date: 2012-03-27T11:23:03Z

[Term]
id: GO:0036166
name: phenotypic switching
namespace: biological_process
def: "A reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations. Phenotypic switching begins with changes in cell morphology and altered gene expression patterns and ends when the morphology of a population of cells has reverted back to the default state, accompanied by altered expression patterns. For example, Candida albicans switches from a unicellular form to an invasive multicellular filamentous form upon infection of host tissue, and from white cells to opaque cells for sexual mating. Phenotypic switching also occurs in multicellular organisms; smooth muscle cells (SMCs) exhibit phenotypic transitions to allow rapid adaption to fluctuating environmental cues." [GOC:bf, GOC:di, PMID:12443899, PMID:22406749, PMID:8456504, Wikipedia:Phenotypic_switching]
comment: Mating type switching is not considered a type of phenotypic switching: for mating type switching, consider instead annotating to 'mating type switching ; GO:0007533'.
synonym: "phenotypic dimorphism" RELATED [Wikipedia:Phenotypic_switching]
is_a: GO:0009987 ! cellular process
created_by: rfoulger
creation_date: 2012-03-27T01:31:28Z

[Term]
id: GO:0036167
name: phenotypic switching in response to host
namespace: biological_process
def: "A reversible switch of a cell from one phenotype to another that occurs upon infection of a host or host cell. For example, Candida albicans switches from a unicellular form to an invasive multicellular filamentous form upon infection of host tissue. Phenotypic switching begins with changes in cell morphology and altered gene expression patterns and ends when the morphology of a population of cells has reverted back to the default state, accompanied by altered expression patterns." [GOC:di, PMID:16696644, Wikipedia:Phenotypic_switching]
is_a: GO:0036166 ! phenotypic switching
is_a: GO:0044764 ! multi-organism cellular process
is_a: GO:0075136 ! response to host
created_by: rfoulger
creation_date: 2012-03-27T01:44:24Z

[Term]
id: GO:0036168
name: filamentous growth of a population of unicellular organisms in response to heat
namespace: biological_process
def: "The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to an increase in temperature." [GOC:di, PMID:17554048]
is_a: GO:0009408 ! response to heat
is_a: GO:0044182 ! filamentous growth of a population of unicellular organisms
created_by: rfoulger
creation_date: 2012-03-27T03:53:28Z

[Term]
id: GO:0036169
name: 3-methoxy-4-hydroxy-5-decaprenylbenzoic acid decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-methoxy-4-hydroxy-5-decaprenylbenzoic acid -> 2-methoxy-6-decaprenylphenol + CO2." [GOC:mw, PMID:620805, PMID:7028108]
is_a: GO:0016831 ! carboxy-lyase activity
created_by: rfoulger
creation_date: 2012-03-27T04:47:47Z

[Term]
id: GO:0036170
name: filamentous growth of a population of unicellular organisms in response to starvation
namespace: biological_process
def: "The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to deprivation of nourishment." [GOC:di, PMID:17554048]
is_a: GO:0042594 ! response to starvation
is_a: GO:0044182 ! filamentous growth of a population of unicellular organisms
created_by: rfoulger
creation_date: 2012-03-27T03:53:28Z

[Term]
id: GO:0036171
name: filamentous growth of a population of unicellular organisms in response to chemical stimulus
namespace: biological_process
def: "The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a chemical stimulus." [GOC:di, PMID:17554048]
is_a: GO:0044182 ! filamentous growth of a population of unicellular organisms
relationship: part_of GO:0042221 ! response to chemical
created_by: rfoulger
creation_date: 2012-03-27T03:53:28Z

[Term]
id: GO:0036172
name: thiamine salvage
namespace: biological_process
def: "A process that generates thiamine (vitamin B1) from derivatives of it without de novo synthesis." [PMID:15150256, PMID:16952958]
xref: MetaCyc:PWY-6896
xref: MetaCyc:PWY-6897
xref: MetaCyc:PWY-6898
is_a: GO:0008655 ! pyrimidine-containing compound salvage
is_a: GO:0009228 ! thiamine biosynthetic process
created_by: rfoulger
creation_date: 2012-03-29T10:31:05Z

[Term]
id: GO:0036173
name: thiosulfate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the inorganic anion thiosulfate, a sulfur oxide that has formula O3S2." [CHEBI:16094, GOC:db, PMID:2188959]
is_a: GO:0043168 ! anion binding
is_a: GO:1901681 ! sulfur compound binding
created_by: rfoulger
creation_date: 2012-03-29T10:38:15Z

[Term]
id: GO:0036174
name: butane monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: butane + O2 + NAD(P)H + H+ = butanol + NAD(P)+ + H2O." [GOC:dh, PMID:17526838, PMID:19383682]
synonym: "sBMO" RELATED [PMID:19383682]
synonym: "soluble butane monooxygenase" RELATED [PMID:19383682]
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
created_by: rfoulger
creation_date: 2012-03-29T10:42:07Z

[Term]
id: GO:0036175
name: ribonucleoside-diphosphate reductase activity, glutaredoxin disulfide as acceptor
namespace: molecular_function
def: "Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + glutaredoxin disulfide + H2O -> ribonucleoside diphosphate + glutaredoxin." [EC:1.17.4.1, GOC:bf, GOC:pde, PMID:7476363]
xref: Reactome:REACT_101834 "NDP + reduced glutaredoxin => dNDP + oxidized glutaredoxin + H2O, Xenopus tropicalis"
xref: Reactome:REACT_103240 "NDP + reduced glutaredoxin => dNDP + oxidized glutaredoxin + H2O, Mus musculus"
xref: Reactome:REACT_107455 "NDP + reduced glutaredoxin => dNDP + oxidized glutaredoxin + H2O, Bos taurus"
xref: Reactome:REACT_30508 "NDP + reduced glutaredoxin => dNDP + oxidized glutaredoxin + H2O, Gallus gallus"
xref: Reactome:REACT_31147 "NDP + reduced glutaredoxin => dNDP + oxidized glutaredoxin + H2O, Caenorhabditis elegans"
xref: Reactome:REACT_375 "NDP + reduced glutaredoxin => dNDP + oxidized glutaredoxin + H2O, Homo sapiens"
xref: Reactome:REACT_83827 "NDP + reduced glutaredoxin => dNDP + oxidized glutaredoxin + H2O, Canis familiaris"
xref: Reactome:REACT_85022 "NDP + reduced glutaredoxin => dNDP + oxidized glutaredoxin + H2O, Danio rerio"
is_a: GO:0061731 ! ribonucleoside-diphosphate reductase activity
created_by: rfoulger
creation_date: 2012-03-29T11:12:42Z

[Term]
id: GO:0036176
name: response to neutral pH
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a neutral pH (pH close to 7) stimulus. pH is a measure of the acidity or basicity of an aqueous solution." [GOC:di, http:http\://en.wikipedia.org/wiki/PH]
is_a: GO:0009268 ! response to pH
created_by: rfoulger
creation_date: 2012-03-29T01:38:00Z

[Term]
id: GO:0036177
name: filamentous growth of a population of unicellular organisms in response to pH
namespace: biological_process
def: "The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution." [GOC:di, http://en.wikipedia.org/wiki/PH]
is_a: GO:0009268 ! response to pH
is_a: GO:0044182 ! filamentous growth of a population of unicellular organisms
created_by: rfoulger
creation_date: 2012-03-29T01:43:04Z

[Term]
id: GO:0036178
name: filamentous growth of a population of unicellular organisms in response to neutral pH
namespace: biological_process
def: "The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a neutral pH (pH close to 7) stimulus." [GOC:di, PMID:6374461]
is_a: GO:0036176 ! response to neutral pH
is_a: GO:0036177 ! filamentous growth of a population of unicellular organisms in response to pH
created_by: rfoulger
creation_date: 2012-03-29T01:43:47Z

[Term]
id: GO:0036179
name: osteoclast maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for an osteoclast cell to attain its fully functional state. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, and which typically differentiates from monocytes." [CL:0000092, GOC:pg]
synonym: "chondroclast maturation" RELATED [CL:0000092]
is_a: GO:0048469 ! cell maturation
relationship: part_of GO:0036035 ! osteoclast development
created_by: rfoulger
creation_date: 2012-03-29T02:04:00Z

[Term]
id: GO:0036180
name: filamentous growth of a population of unicellular organisms in response to biotic stimulus
namespace: biological_process
def: "The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a biotic (living) stimulus." [GOC:di]
is_a: GO:0009607 ! response to biotic stimulus
is_a: GO:0044182 ! filamentous growth of a population of unicellular organisms
created_by: rfoulger
creation_date: 2012-03-30T04:12:40Z

[Term]
id: GO:0036181
name: protein localization to linear element
namespace: biological_process
def: "A cellular protein localization process in which a protein is transported to, or maintained at, a linear element. A linear element is a proteinaceous scaffold associated with S. pombe chromosomes during meiotic prophase." [GOC:mah, PMID:19756689]
synonym: "protein localisation to linear element" EXACT [GOC:mah]
is_a: GO:1903084 ! protein localization to condensed nuclear chromosome
created_by: rfoulger
creation_date: 2012-03-30T04:14:17Z

[Term]
id: GO:0036182
name: asperthecin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving asperthecin, an anthraquinone pigment obtained from the mould Aspergillus nidulans." [CHEBI:64161, GOC:di]
synonym: "asperthecin metabolism" EXACT [GOC:bf]
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901661 ! quinone metabolic process
created_by: rfoulger
creation_date: 2012-04-16T11:35:24Z

[Term]
id: GO:0036183
name: asperthecin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of asperthecin, an anthraquinone pigment obtained from the mould Aspergillus nidulans." [CHEBI:64161, GOC:di]
synonym: "asperthecin breakdown" EXACT [GOC:bf]
synonym: "asperthecin catabolism" EXACT [GOC:bf]
synonym: "asperthecin degradation" EXACT [GOC:bf]
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0036182 ! asperthecin metabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901662 ! quinone catabolic process
created_by: rfoulger
creation_date: 2012-04-16T11:36:38Z

[Term]
id: GO:0036184
name: asperthecin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of asperthecin, an anthraquinone pigment obtained from the mould Aspergillus nidulans." [CHEBI:64161, GOC:di]
synonym: "asperthecin biosynthesis" EXACT [GOC:bf]
synonym: "asperthecin formation" EXACT [GOC:bf]
synonym: "asperthecin synthesis" EXACT [GOC:bf]
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0036182 ! asperthecin metabolic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901663 ! quinone biosynthetic process
created_by: rfoulger
creation_date: 2012-04-16T11:36:56Z

[Term]
id: GO:0036185
name: 13-lipoxin reductase activity
namespace: molecular_function
def: "Definition: Catalysis of the reaction: 15-oxolipoxin A4 + NAD(P)H + H+ = 13,14-dihydro-15-oxolipoxin A4 + NAD(P)+." [GOC:mw, PMID:10837478]
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
created_by: rfoulger
creation_date: 2012-04-16T02:28:19Z

[Term]
id: GO:0036186
name: early phagosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding an early phagosome." [GOC:phg]
synonym: "early phagocytic vesicle membrane" EXACT [GOC:bf]
is_a: GO:0030670 ! phagocytic vesicle membrane
relationship: part_of GO:0032009 ! early phagosome
created_by: rfoulger
creation_date: 2012-04-16T02:37:30Z

[Term]
id: GO:0036187
name: cell growth mode switching, budding to filamentous
namespace: biological_process
def: "The process in which a cell switches from growing as a round budding cell to growing as a filament (elongated cells attached end-to-end). An example of this is the yeast-hyphal transition of Candida albicans." [GOC:di]
synonym: "yeast to hyphal transition" RELATED [GOC:di]
is_a: GO:0070784 ! regulation of growth of unicellular organism as a thread of attached cells
created_by: rfoulger
creation_date: 2012-04-18T11:32:57Z

[Term]
id: GO:0036188
name: abieta-7,13-dien-18-al dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: abieta-7,13-diene-18-al + H2O + NAD+ = abieta-7,13-diene-18-oate + NADH + H+." [EC:1.2.1.74]
synonym: "abietadienal dehydrogenase" BROAD [EC:1.2.1.74]
xref: EC:1.2.1.74
xref: KEGG:R06357
xref: MetaCyc:1.2.1.74-RXN
xref: RHEA:26228
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
created_by: rfoulger
creation_date: 2012-04-18T01:46:19Z

[Term]
id: GO:0036189
name: abieta-7,13-diene hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: abieta-7,13-diene + NADPH + H+ + O2 = abieta-7,13-dien-18-ol + NADP+ + H2O." [EC:1.14.13.108]
synonym: "abietadiene hydroxylase" BROAD [EC:1.14.13.108]
xref: EC:1.14.13.108
xref: KEGG:R06351
xref: MetaCyc:RXN-8507
xref: RHEA:26220
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
created_by: rfoulger
creation_date: 2012-04-19T10:57:05Z

[Term]
id: GO:0036190
name: indole-2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: indole + NAD(P)H + H+ + O2 = indolin-2-one + NAD(P)+ + H2O." [EC:1.14.13.137]
xref: EC:1.14.13.137
xref: KEGG:R07403
xref: RHEA:31902
xref: RHEA:31906
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
created_by: rfoulger
creation_date: 2012-04-19T11:24:48Z

[Term]
id: GO:0036191
name: indolin-2-one monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: indolin-2-one + NAD(P)H + H+ + O2 = 3-hydroxyindolin-2-one + NAD(P)+ + H2O." [EC:1.14.13.138]
synonym: "indolin-2-one,NAD(P)H:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.138]
xref: EC:1.14.13.138
xref: KEGG:R07421
xref: RHEA:31922
xref: RHEA:31926
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
created_by: rfoulger
creation_date: 2012-04-19T11:38:01Z

[Term]
id: GO:0036192
name: 3-hydroxyindolin-2-one monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxyindolin-2-one + NAD(P)H + H+ + O2 = 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + NAD(P)+ + H2O." [EC:1.14.13.139]
synonym: "3-hydroxyindolin-2-one,NAD(P)H:oxygen oxidoreductase (2-hydroxy-2H-1,4-benzoxazin-3(4H)-one-forming)" EXACT [EC:1.14.13.139]
xref: EC:1.14.13.139
xref: KEGG:R07422
xref: RHEA:31930
xref: RHEA:31934
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
created_by: rfoulger
creation_date: 2012-04-19T11:45:33Z

[Term]
id: GO:0036193
name: 2-hydroxy-1,4-benzoxazin-3-one monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + NAD(P)H + H+ + O2 = 2,4-dihydroxy-2H-1,4-benzoxazin-3(4H)-one + NAD(P)+ + H2O." [EC:1.14.13.140]
xref: EC:1.14.13.140
xref: KEGG:R07423
xref: RHEA:31938
xref: RHEA:31942
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
created_by: rfoulger
creation_date: 2012-04-19T11:54:34Z

[Term]
id: GO:0036194
name: muscle cell projection
namespace: cellular_component
def: "A prolongation or process extending from a muscle cell. A muscle cell is a mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns." [CL:0000187, GOC:kmv, PMID:15930100, PMID:22464329]
synonym: "muscle arm" NARROW [GOC:kmv]
synonym: "myocyte projection" EXACT [CL:0000187]
synonym: "myopodia" NARROW [GOC:kmv]
is_a: GO:0042995 ! cell projection
created_by: rfoulger
creation_date: 2012-04-20T10:20:47Z

[Term]
id: GO:0036195
name: muscle cell projection membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a muscle cell projection." [CL:0000187, GOC:kmv, PMID:15930100, PMID:22464329]
is_a: GO:0031253 ! cell projection membrane
intersection_of: GO:0031253 ! cell projection membrane
intersection_of: part_of GO:0036194 ! muscle cell projection
relationship: part_of GO:0036194 ! muscle cell projection
created_by: rfoulger
creation_date: 2012-04-20T10:21:51Z

[Term]
id: GO:0036196
name: zymosterol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving zymosterol, (5alpha-cholesta-8,24-dien-3beta-ol)." [CHEBI:18252, GOC:yaf]
is_a: GO:0016125 ! sterol metabolic process
is_a: GO:1902652 ! secondary alcohol metabolic process
created_by: rfoulger
creation_date: 2012-04-20T10:27:06Z

[Term]
id: GO:0036197
name: zymosterol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of zymosterol, (5alpha-cholesta-8,24-dien-3beta-ol)." [CHEBI:18252, GOC:yaf, MetaCyc:PWY-6074]
synonym: "zymosterol anabolism" EXACT [GOC:bf]
synonym: "zymosterol biosynthesis" EXACT [GOC:bf]
synonym: "zymosterol formation" EXACT [GOC:bf]
synonym: "zymosterol synthesis" EXACT [GOC:bf]
xref: MetaCyc:PWY-6074
xref: UniPathway:UPA00770
is_a: GO:0016126 ! sterol biosynthetic process
is_a: GO:0036196 ! zymosterol metabolic process
is_a: GO:1902653 ! secondary alcohol biosynthetic process
created_by: rfoulger
creation_date: 2012-04-20T10:28:46Z

[Term]
id: GO:0036198
name: dTMP salvage
namespace: biological_process
def: "Any process which produces dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate) without de novo synthesis." [GOC:yaf, UniPathway:UPA00578]
synonym: "deoxythymidine monophosphate biosynthesis via salvage pathway" RELATED [GOC:yaf, PMID:5387459, UniPathway:UPA00578]
synonym: "dTMP biosynthesis via salvage pathway" RELATED [GOC:yaf, PMID:5387459, UniPathway:UPA00578]
xref: UniPathway:UPA00578
is_a: GO:0006231 ! dTMP biosynthetic process
is_a: GO:0010139 ! pyrimidine deoxyribonucleotide salvage
created_by: rfoulger
creation_date: 2012-04-20T10:33:28Z

[Term]
id: GO:0036199
name: cholest-4-en-3-one 26-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cholest-4-en-3-one + NADH + H+ + O2 = 26-hydroxycholest-4-en-3-one + NAD+ + H2O. This reaction involves the hydroxylation of the C26 carbon, followed by oxidation of the alcohol to the carboxylic acid via the aldehyde intermediate." [EC:1.14.13.141]
xref: EC:1.14.13.141
xref: KEGG:R09859
xref: RHEA:31946
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
created_by: rfoulger
creation_date: 2012-04-20T02:03:05Z

[Term]
id: GO:0036200
name: 3-ketosteroid 9-alpha-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: androsta-1,4-diene-3,17-dione + NADH + H+ + O2 = 9alpha-hydroxyandrosta-1,4-diene-3,17-dione + NAD+ + H2O." [EC:1.14.13.142]
synonym: "3-ketosteroid 9alpha-hydroxylase activity" EXACT [EC:1.14.13.142]
synonym: "KshAB activity" EXACT [EC:1.14.13.142]
xref: EC:1.14.13.142
xref: KEGG:R09860
xref: RHEA:32202
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
created_by: rfoulger
creation_date: 2012-04-20T02:09:47Z

[Term]
id: GO:0036201
name: ent-isokaurene C2-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: ent-isokaurene + O2 + NADPH + H+ = ent-2alpha-hydroxyisokaurene + H2O + NADP+." [EC:1.14.13.143]
xref: EC:1.14.13.143
xref: KEGG:R09861
xref: RHEA:31950
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
created_by: rfoulger
creation_date: 2012-04-20T02:21:33Z

[Term]
id: GO:0036202
name: ent-cassa-12,15-diene 11-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: ent-cassa-12,15-diene + O2 + NADPH + H+ = ent-11beta-hydroxycassa-12,15-diene + NADP+ + H2O." [EC:1.14.13.145]
synonym: "ent-cassadiene C11alpha-hydroxylase activity" EXACT [EC:1.14.13.145]
xref: EC:1.14.13.145
xref: KEGG:R09866
xref: RHEA:31970
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
created_by: rfoulger
creation_date: 2012-04-20T02:34:13Z

[Term]
id: GO:0036203
name: taxoid 14-beta-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + O2 + NADPH + H+ = 10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate + NADP+ + H2O." [EC:1.14.13.146]
xref: EC:1.14.13.146
xref: KEGG:R09867
xref: RHEA:31974
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
created_by: rfoulger
creation_date: 2012-04-20T02:40:54Z

[Term]
id: GO:0036204
name: abieta-7,13-dien-18-ol hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: abieta-7,13-dien-18-ol + NADPH + H+ + O2 = abieta-7,13-dien-18-al + NADP+ + 2 H2O. This is a two step reaction. The first step is: abieta-7,13-dien-18-ol + NADPH + H+ + O2 = abieta-7,13-dien-18,18-diol + + NADP+ + H2O. The second step is a spontaneous reaction: abieta-7,13-dien-18,18-diol = abieta-7,13-dien-18-al + H2O." [EC:1.14.13.109]
xref: EC:1.14.13.109
xref: KEGG:R06354
xref: MetaCyc:RXN-12799
xref: RHEA:26224
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
created_by: rfoulger
creation_date: 2012-04-24T02:37:15Z

[Term]
id: GO:0036205
name: histone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a histone protein by individual cells." [GOC:krc]
comment: This term was created even though it describes a process relating to a group of gene products, because histones are highly conserved proteins that are essential components of cellular chromatin in eukaryotic cells.
synonym: "histone protein catabolic process" EXACT [GOC:bf, GOC:jl]
is_a: GO:0044257 ! cellular protein catabolic process
created_by: rfoulger
creation_date: 2012-04-24T04:48:48Z

[Term]
id: GO:0036206
name: regulation of histone gene expression
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of expression of a histone-encoding gene. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein." [GOC:bf, GOC:krc]
comment: This term was created even though it describes a process relating to a group of gene products, because histones are highly conserved proteins that are essential components of cellular chromatin in eukaryotic cells.
synonym: "regulation of expression of histone-encoding gene" EXACT [GOC:bf]
is_a: GO:0010468 ! regulation of gene expression
created_by: rfoulger
creation_date: 2012-04-24T05:01:28Z

[Term]
id: GO:0036207
name: positive regulation of histone gene expression
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of expression of a histone-encoding gene. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein." [GOC:bf, GOC:krc]
comment: This term was created even though it describes a process relating to a group of gene products, because histones are highly conserved proteins that are essential components of cellular chromatin in eukaryotic cells.
synonym: "activation of histone gene expression" NARROW [GOC:bf]
synonym: "positive regulation of expression of histone-encoding gene" EXACT [GOC:bf]
synonym: "up-regulation of histone gene expression" EXACT [GOC:bf]
synonym: "upregulation of histone gene expression" EXACT [GOC:bf]
is_a: GO:0010628 ! positive regulation of gene expression
is_a: GO:0036206 ! regulation of histone gene expression
created_by: rfoulger
creation_date: 2012-04-25T09:27:42Z

[Term]
id: GO:0036208
name: negative regulation of histone gene expression
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of expression of a histone-encoding gene. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein." [GOC:bf, GOC:krc]
comment: This term was created even though it describes a process relating to a group of gene products, because histones are highly conserved proteins that are essential components of cellular chromatin in eukaryotic cells.
synonym: "down-regulation of histone gene expression" EXACT [GOC:bf]
synonym: "downregulation of histone gene expression" EXACT [GOC:bf]
synonym: "inhibition of histone gene expression" NARROW [GOC:bf]
synonym: "negative regulation of expression of histone-encoding gene" EXACT [GOC:bf]
is_a: GO:0010629 ! negative regulation of gene expression
is_a: GO:0036206 ! regulation of histone gene expression
created_by: rfoulger
creation_date: 2012-04-25T09:29:43Z

[Term]
id: GO:0036209
name: 9beta-pimara-7,15-diene oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 9beta-pimara-7,15-diene + 3 O2 + 3 NADPH + 3 H+ = 9beta-pimara-7,15-dien-19-oate + 3 NADP+ + 4 H2O. This is a three-step reaction: (a) 9beta-pimara-7,15-diene + O2 + NADPH + H+ = 9beta-pimara-7,15-dien-19-ol + NADP+ + H2O, (b) 9beta-pimara-7,15-dien-19-ol + O2 + NADPH + H+ = 9neta-pimara-7,15-dien-19-al + NADP+ + 2 H2O, (c) 9beta-pimara-7,15-dien-19-al + O2 + NADPH + H+ = 9beta-pimara-7,15-dien-19-oate + NADP+ + H2O." [EC:1.14.13.144]
xref: EC:1.14.13.144
xref: KEGG:R09865
xref: RHEA:31954
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
created_by: rfoulger
creation_date: 2012-04-25T11:11:55Z

[Term]
id: GO:0036210
name: protein modification process in other organism
namespace: biological_process
def: "The covalent alteration performed by one organism of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) in another organism. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]
synonym: "protein modification in other organism" EXACT [GOC:bf]
is_a: GO:0036211 ! protein modification process
is_a: GO:0044033 ! multi-organism metabolic process
created_by: rfoulger
creation_date: 2012-04-26T01:29:29Z

[Term]
id: GO:0036211
name: protein modification process
namespace: biological_process
def: "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]
synonym: "protein modification" EXACT [GOC:bf]
is_a: GO:0019538 ! protein metabolic process
is_a: GO:0043412 ! macromolecule modification
created_by: rfoulger
creation_date: 2012-04-26T01:47:12Z

[Term]
id: GO:0036212
name: contractile ring maintenance
namespace: biological_process
def: "The process in which the contractile ring is maintained, typically in response to an internal or external cue." [GOC:mah, GOC:vw]
comment: This term can be used to annotate maintenance of either bacterial or fungal contractile rings.
is_a: GO:0032506 ! cytokinetic process
relationship: part_of GO:0061640 ! cytoskeleton-dependent cytokinesis
created_by: rfoulger
creation_date: 2012-04-26T02:57:39Z

[Term]
id: GO:0036213
name: contractile ring contraction
namespace: biological_process
def: "The process of an actomyosin ring getting smaller in diameter." [GOC:mah, GOC:vw]
comment: This term can be used to annotate contraction of either bacterial or fungal contractile rings.
is_a: GO:0032506 ! cytokinetic process
relationship: part_of GO:0061640 ! cytoskeleton-dependent cytokinesis
created_by: rfoulger
creation_date: 2012-04-26T02:58:18Z

[Term]
id: GO:0036214
name: contractile ring localization
namespace: biological_process
def: "The process in which a contractile ring is assembled and/or maintained in a specific location." [GOC:mah, GOC:vw]
comment: This term can be used to annotate localization of either bacterial or fungal contractile rings.
is_a: GO:0032506 ! cytokinetic process
relationship: part_of GO:0061640 ! cytoskeleton-dependent cytokinesis
created_by: rfoulger
creation_date: 2012-04-26T02:58:50Z

[Term]
id: GO:0036215
name: response to stem cell factor
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stem cell factor (SCF) stimulus." [GOC:uh, PR:000009345]
synonym: "response to hematopoietic growth factor KL" EXACT [PR:000009345]
synonym: "response to KIT ligand" EXACT [PR:000009345]
synonym: "response to SCF" EXACT [PR:000009345]
synonym: "response to stem cell factor stimulus" EXACT [GOC:dos]
is_a: GO:0034097 ! response to cytokine
created_by: rfoulger
creation_date: 2012-04-27T10:26:37Z

[Term]
id: GO:0036216
name: cellular response to stem cell factor stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stem cell factor (SCF) stimulus." [GOC:uh, PMID:18787413, PMID:7520444, PR:000009345]
synonym: "cellular response to hematopoietic growth factor KL" EXACT [PR:000009345]
synonym: "cellular response to KIT ligand" EXACT [PR:000009345]
synonym: "cellular response to KITLG" EXACT [PMID:18787413]
synonym: "cellular response to SCF" EXACT [PR:000009345]
is_a: GO:0036215 ! response to stem cell factor
is_a: GO:0071345 ! cellular response to cytokine stimulus
created_by: rfoulger
creation_date: 2012-04-27T10:30:53Z

[Term]
id: GO:0036217
name: dGTP diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: dGTP + H2O = dGMP + diphosphate." [GOC:dgf, KEGG:R01855, PMID:17090528, PMID:22531138]
synonym: "2'-deoxyguanosine 5'-triphosphate diphosphohydrolase" EXACT [KEGG:R01855]
xref: KEGG:R01855
xref: RHEA:28362
is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity
created_by: rfoulger
creation_date: 2012-05-08T01:47:59Z

[Term]
id: GO:0036218
name: dTTP diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: dTTP + H2O = dTMP + diphosphate." [GOC:dgf, PMID:22531138]
xref: EC:3.6.1.-
xref: MetaCyc:RXN0-5107
xref: RHEA:28534
is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity
created_by: rfoulger
creation_date: 2012-05-08T01:47:59Z

[Term]
id: GO:0036219
name: GTP diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP + H2O = GMP + diphosphate." [GOC:dgf, KEGG:R00426, PMID:22531138]
synonym: "GTP diphosphohydrolase (diphosphate-forming); guanosine 5'-triphosphate pyrophosphohydrolase" EXACT [KEGG:R00426]
synonym: "GTP diphosphohydrolase activity" EXACT [GOC:bf]
xref: KEGG:R00426
xref: RHEA:29391
is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity
created_by: rfoulger
creation_date: 2012-05-08T01:47:59Z

[Term]
id: GO:0036220
name: ITP diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: ITP + H2O = IMP + diphosphate." [GOC:dgf, KEGG:R00720, PMID:17899088, PMID:22531138]
synonym: "inosine-5'-triphosphate pyrophosphohydrolase activity" EXACT [KEGG:R00720]
xref: KEGG:R00720
xref: MetaCyc:RXN0-6382
xref: RHEA:29399
is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity
created_by: rfoulger
creation_date: 2012-05-08T01:47:59Z

[Term]
id: GO:0036221
name: UTP diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: UTP + H2O = UMP + diphosphate." [GOC:dgf, KEGG:R00662, PMID:17899088]
synonym: "uridine triphosphate pyrophosphohydrolase activity" EXACT [KEGG:R00662]
xref: KEGG:R00662
xref: RHEA:29395
is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity
created_by: rfoulger
creation_date: 2012-05-08T01:47:59Z

[Term]
id: GO:0036222
name: XTP diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: XTP + H2O = xanthosine 5'-phosphate + diphosphate." [GOC:dgf, PMID:22531138]
synonym: "XTP pyrophosphohydrolase activity" EXACT [KEGG:R02720]
xref: EC:3.6.1.-
xref: KEGG:R02720
xref: MetaCyc:RXN0-1603
xref: RHEA:28610
is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity
created_by: rfoulger
creation_date: 2012-05-08T01:47:59Z

[Term]
id: GO:0036223
name: cellular response to adenine starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of adenine." [CHEBI:16708, GOC:ai]
synonym: "cellular response to adenine deprivation" EXACT [GOC:bf]
is_a: GO:0009267 ! cellular response to starvation
created_by: rfoulger
creation_date: 2012-05-09T02:26:52Z

[Term]
id: GO:0036224
name: pairing center
namespace: cellular_component
def: "A special chromosome region located towards one end of a chromosome that contains dispersed copies of short, repetitive DNA sequences and functions as a cis-acting element essential for presynaptic homologous chromosome pairing and chromosome-nuclear envelope attachment." [GOC:kmv, PMID:18597662]
synonym: "homolog recognition region" EXACT [GOC:kmv]
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000794 ! condensed nuclear chromosome
created_by: rfoulger
creation_date: 2012-05-09T02:28:53Z

[Term]
id: GO:0036225
name: cellular response to vitamin B1 starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of vitamin B1 (also called thiamin and thiamine)." [CHEBI:18385, GOC:al]
synonym: "cellular response to thiamin starvation" EXACT [CHEBI:18385, Wikipedia:Thiamine]
synonym: "cellular response to vitamin B1 deprivation" EXACT [GOC:bf]
is_a: GO:0009267 ! cellular response to starvation
created_by: rfoulger
creation_date: 2012-05-09T02:35:55Z

[Term]
id: GO:0036226
name: obsolete mitotic cell cycle arrest in response to glucose starvation
namespace: biological_process
def: "OBSOLETE. The process in which the mitotic cell cycle is halted during one of the normal phases (G1, S, G2, M) as a result of deprivation of glucose." [GOC:al, GOC:mah, PMID:958201]
comment: This term was made obsolete because it is superfluous, as only the more specific 'mitotic G2 cell cycle arrest in response to glucose starvation' has been observed.
synonym: "cell cycle arrest in response to glucose starvation" BROAD []
is_obsolete: true
created_by: rfoulger
creation_date: 2012-05-09T02:43:22Z

[Term]
id: GO:0036227
name: mitotic G2 cell cycle arrest in response to glucose starvation
namespace: biological_process
def: "The process in which the mitotic cell cycle is halted during G2 phase as a result of deprivation of glucose." [GOC:al, GOC:mah, GOC:mtg_cell_cycle, PMID:958201]
is_a: GO:0071850 ! mitotic cell cycle arrest
created_by: rfoulger
creation_date: 2012-05-09T02:45:49Z

[Term]
id: GO:0036228
name: protein targeting to nuclear inner membrane
namespace: biological_process
def: "The process of targeting a protein to, and inserting it into, the nuclear inner membrane; usually uses signals contained within the protein." [GOC:dgf, PMID:16929305]
synonym: "protein targeting to INM" EXACT [PMID:16929305]
is_a: GO:0006612 ! protein targeting to membrane
is_a: GO:0044744 ! protein targeting to nucleus
is_a: GO:0090435 ! protein localization to nuclear envelope
created_by: rfoulger
creation_date: 2012-05-11T10:42:34Z

[Term]
id: GO:0036229
name: L-glutamine import
namespace: biological_process
def: "The directed movement of L-glutamine, the L-enantiomer of glutamine, into a cell or organelle." [CHEBI:18050, GOC:al]
synonym: "L-glutamine uptake" EXACT [GOC:bf]
is_a: GO:0006868 ! glutamine transport
is_a: GO:0043092 ! L-amino acid import
created_by: rfoulger
creation_date: 2012-05-11T10:46:21Z

[Term]
id: GO:0036230
name: granulocyte activation
namespace: biological_process
def: "The change in morphology and behavior of a granulocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [CL:0000094, GOC:nhn]
is_a: GO:0002274 ! myeloid leukocyte activation
created_by: rfoulger
creation_date: 2012-05-11T10:57:48Z

[Term]
id: GO:0036231
name: L-threonine import
namespace: biological_process
def: "The directed movement of L-threonine, the L-enantiomer of threonine, into a cell or organelle." [CHEBI:16857, GOC:al]
synonym: "L-threonine uptake" EXACT [GOC:bf]
is_a: GO:0015826 ! threonine transport
is_a: GO:0043092 ! L-amino acid import
created_by: rfoulger
creation_date: 2012-05-11T10:46:21Z

[Term]
id: GO:0036232
name: L-tyrosine import
namespace: biological_process
def: "The directed movement of L-tyrosine, the L-enantiomer of tyrosine, into a cell or organelle." [CHEBI:17895, GOC:al]
synonym: "L-tyrosine uptake" EXACT [GOC:bf]
is_a: GO:0015828 ! tyrosine transport
is_a: GO:0043092 ! L-amino acid import
created_by: rfoulger
creation_date: 2012-05-11T10:46:21Z

[Term]
id: GO:0036233
name: glycine import
namespace: biological_process
def: "The directed movement of glycine into a cell or organelle." [GOC:al]
is_a: GO:0015816 ! glycine transport
is_a: GO:0043092 ! L-amino acid import
created_by: rfoulger
creation_date: 2012-05-11T01:16:45Z

[Term]
id: GO:0036234
name: deglucuronidation
namespace: biological_process
def: "The removal of glucuronic acid from a conjugated substrate." [GOC:BHF, GOC:vk, PMID:22294686, PMID:8560473]
is_a: GO:0019585 ! glucuronate metabolic process
created_by: rfoulger
creation_date: 2012-05-18T04:23:04Z

[Term]
id: GO:0036235
name: acyl deglucuronidation
namespace: biological_process
def: "The removal of glucuronic acid from an acyl-glucuronide." [GOC:BHF, GOC:vk, PMID:22294686]
is_a: GO:0036234 ! deglucuronidation
created_by: rfoulger
creation_date: 2012-05-18T04:24:11Z

[Term]
id: GO:0036236
name: acyl glucuronidation
namespace: biological_process
def: "The modification of an substrate by the conjugation of glucuronic acid to form an acyl-glucuronide (also called an acyl-glucuronoside)." [GOC:BHF, GOC:vk, PMID:12485951, PMID:22294686]
is_a: GO:0052695 ! cellular glucuronidation
created_by: rfoulger
creation_date: 2012-05-18T04:26:25Z

[Term]
id: GO:0036237
name: acyl-glucuronidase activity
namespace: molecular_function
def: "Catalysis of the reaction: an acyl-glucuronoside + H2O = an alcohol + D-glucuronate." [GOC:BHF, GOC:vk, PMID:22294686]
synonym: "acyl-glucuronide deglucuronidation activity" NARROW [PMID:22294686]
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds
created_by: rfoulger
creation_date: 2012-05-18T04:32:25Z

[Term]
id: GO:0036238
name: gallate dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: gallate + O2 = (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate." [EC:1.13.11.57, PMID:16030014]
xref: EC:1.13.11.57
xref: KEGG:R09565
xref: MetaCyc:GALLATE-DIOXYGENASE-RXN
xref: RHEA:28930
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
created_by: rfoulger
creation_date: 2012-05-22T01:54:09Z

[Term]
id: GO:0036239
name: taxoid 7beta-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: taxusin + O2 + NADPH + H+ = 7beta-hydroxytaxusin + NADP+ + H2O." [EC:1.14.13.147]
xref: EC:1.14.13.147
xref: KEGG:R09868
xref: MetaCyc:RXN-12885
xref: RHEA:31978
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
created_by: rfoulger
creation_date: 2012-05-22T02:13:21Z

[Term]
id: GO:0036240
name: septal periplasm
namespace: cellular_component
def: "The region between the plasma membrane and the cell wall, as found in organisms such as filamentous fungi." [GOC:di, PMID:21564341]
synonym: "cell wall-enclosed septal periplasm" EXACT [GOC:di]
is_a: GO:0042597 ! periplasmic space
created_by: rfoulger
creation_date: 2012-05-23T10:18:09Z

[Term]
id: GO:0036241
name: glutamate catabolic process to 4-hydroxybutyrate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glutamate into 4-hydroxybutyrate." [GOC:bf, MetaCyc:PWY-4321]
comment: In the catabolism of glutamate in mammals, succinate semialdehyde is converted to succinate (see GO:0006540). Plants can utilize an alternative route, converting succinic semialdehyde to 4-hydroxybutyrate using gamma-hydroxybutyrate dehydrogenase.
synonym: "glutamate degradation to 4-hydroxybutyrate" EXACT [MetaCyc:PWY-4321]
is_a: GO:0006538 ! glutamate catabolic process
is_a: GO:0006631 ! fatty acid metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process
relationship: has_part GO:0047577 ! 4-hydroxybutyrate dehydrogenase activity
created_by: rfoulger
creation_date: 2012-05-23T02:17:05Z

[Term]
id: GO:0036242
name: glutamate catabolic process to succinate via 2-oxoglutarate-dependent GABA-transaminase activity
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glutamate into succinate, that includes the conversion of 4-aminobutyrate to succinate semialdehyde by the 2-oxoglutarate-dependent gamma aminobutyrate (GABA) transaminase." [GOC:bf, MetaCyc:PWY-4321]
comment: While mammals only have 2-oxoglutarate-dependent GABA-transaminase, both 2-oxoglutarate-dependent and pyruvate-dependent GABA-transaminase activities have been detected in plants.
synonym: "glutamate degradation via gamma aminobutyrate transaminase activity" EXACT [MetaCyc:PWY-4321]
xref: MetaCyc:PWY-4321
xref: MetaCyc:PWY3O-210
is_a: GO:0006540 ! glutamate decarboxylation to succinate
relationship: has_part GO:0034386 ! 4-aminobutyrate:2-oxoglutarate transaminase activity
created_by: rfoulger
creation_date: 2012-05-23T02:28:33Z

[Term]
id: GO:0036243
name: succinate-semialdehyde dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: succinate semialdehyde + NADP+ + H2O = succinate + NADPH + 2 H+." [EC:1.2.1.79, GOC:bf]
comment: This function is similar to EC:1.2.1.24 [succinate-semialdehyde dehydrogenase (NAD+)], and EC:1.2.1.16 [succinate-semialdehyde dehydrogenase (NAD(P)+)], but is specific for NADP+.
synonym: "NADP-dependent succinate-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.79]
synonym: "succinate semialdehyde:NADP+ oxidoreductase activity" EXACT [EC:1.2.1.79]
synonym: "succinic semialdehyde dehydrogenase (NADP+) activity" EXACT [EC:1.2.1.79]
synonym: "succinyl semialdehyde dehydrogenase (NADP+) activity" EXACT [EC:1.2.1.79]
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
created_by: rfoulger
creation_date: 2012-05-23T02:47:52Z

[Term]
id: GO:0036244
name: cellular response to neutral pH
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a neutral pH (pH close to 7) stimulus. pH is a measure of the acidity or basicity of an aqueous solution." [GOC:di, http://en.wikipedia.org/wiki/PH]
is_a: GO:0036176 ! response to neutral pH
is_a: GO:0071467 ! cellular response to pH
created_by: rfoulger
creation_date: 2012-05-28T10:21:03Z

[Term]
id: GO:0036245
name: cellular response to menadione
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a menadione stimulus. Menadione (also called vitamin K3) is a naphthoquinone having a methyl substituent at the 2-position." [CHEBI:28869, GOC:al]
synonym: "cellular response to vitamin K3" EXACT [CHEBI:28869, GOC:al, Wikipedia:Menadione]
is_a: GO:0071310 ! cellular response to organic substance
is_a: GO:1901655 ! cellular response to ketone
created_by: rfoulger
creation_date: 2012-05-28T10:23:02Z

[Term]
id: GO:0036246
name: phytochelatin 2 import into vacuole
namespace: biological_process
def: "The directed movement of phytochelatin 2 (PC2) into the vacuole. Phytochelatin 2 is a glutathione-related peptide composed of (gamma-Glu-Cys)n-Gly where n=2, and where the Glu and Cys residues are linked through a gamma-carboxylamide bond." [CHEBI:64744, GOC:al, PMID:19001374]
synonym: "PC2 import into vacuole" EXACT [GOC:al]
is_a: GO:0035672 ! oligopeptide transmembrane transport
is_a: GO:0071995 ! phytochelatin import into vacuole
created_by: rfoulger
creation_date: 2012-05-31T11:09:20Z

[Term]
id: GO:0036247
name: phytochelatin 3 import into vacuole
namespace: biological_process
def: "The directed movement of phytochelatin 3 (PC3) into the vacuole. Phytochelatin 3 is a glutathione-related peptide composed of (gamma-Glu-Cys)n-Gly where n=3, and where the Glu and Cys residues are linked through a gamma-carboxylamide bond." [CHEBI:64745, GOC:al, PMID:19001374]
synonym: "PC3 import into vacuole" EXACT [GOC:al]
is_a: GO:0035672 ! oligopeptide transmembrane transport
is_a: GO:0071995 ! phytochelatin import into vacuole
created_by: rfoulger
creation_date: 2012-05-31T11:11:03Z

[Term]
id: GO:0036248
name: phytochelatin 4 import into vacuole
namespace: biological_process
def: "The directed movement of phytochelatin 4 (PC4) into the vacuole. Phytochelatin 4 is a glutathione-related peptide composed of (gamma-Glu-Cys)n-Gly where n=4, and where the Glu and Cys residues are linked through a gamma-carboxylamide bond." [CHEBI:64747, GOC:al, PMID:19001374]
synonym: "PC4 import into vacuole" EXACT [GOC:al]
is_a: GO:0035672 ! oligopeptide transmembrane transport
is_a: GO:0071995 ! phytochelatin import into vacuole
created_by: rfoulger
creation_date: 2012-05-31T11:12:08Z

[Term]
id: GO:0036249
name: cadmium ion import into vacuole
namespace: biological_process
def: "The directed movement of cadmium ions into the vacuole." [GOC:al]
synonym: "vacuolar cadmium import" RELATED [GOC:bf]
is_a: GO:0034486 ! vacuolar transmembrane transport
is_a: GO:0070574 ! cadmium ion transmembrane transport
created_by: rfoulger
creation_date: 2012-05-31T11:13:44Z

[Term]
id: GO:0036250
name: peroxisome transport along microtubule
namespace: biological_process
def: "The directed movement of a peroxisome along a microtubule, mediated by motor proteins." [GOC:pm, PMID:21525035]
is_a: GO:0072384 ! organelle transport along microtubule
created_by: rfoulger
creation_date: 2012-05-31T03:09:09Z

[Term]
id: GO:0036251
name: positive regulation of transcription from RNA polymerase II promoter in response to salt stress
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under salt stress. The stress is usually an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:al]
is_a: GO:0061393 ! positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress
is_a: GO:0061416 ! regulation of transcription from RNA polymerase II promoter in response to salt stress
created_by: rfoulger
creation_date: 2012-06-12T11:38:22Z

[Term]
id: GO:0036252
name: positive regulation of transcription from RNA polymerase II promoter in response to menadione
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a menadione stimulus. Menadione (also called vitamin K3) is a naphthoquinone having a methyl substituent at the 2-position." [CHEBI:28869, GOC:al]
synonym: "positive regulation of transcription from RNA polymerase II promoter in response to menadione stress" NARROW [GOC:al]
is_a: GO:0036003 ! positive regulation of transcription from RNA polymerase II promoter in response to stress
is_a: GO:1901522 ! positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
relationship: part_of GO:0036245 ! cellular response to menadione
created_by: rfoulger
creation_date: 2012-06-12T11:40:58Z

[Term]
id: GO:0036253
name: response to amiloride
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amiloride stimulus." [CHEBI:2639, GOC:mah]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: rfoulger
creation_date: 2012-06-15T01:05:35Z

[Term]
id: GO:0036254
name: cellular response to amiloride
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amiloride stimulus." [CHEBI:2639, GOC:mah]
is_a: GO:0036253 ! response to amiloride
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: rfoulger
creation_date: 2012-06-15T01:06:16Z

[Term]
id: GO:0036255
name: response to methylamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylamine stimulus." [CHEBI:16830, GOC:mah]
is_a: GO:0014075 ! response to amine
created_by: rfoulger
creation_date: 2012-06-15T01:07:27Z

[Term]
id: GO:0036256
name: cellular response to methylamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylamine stimulus." [CHEBI:16830, GOC:mah]
is_a: GO:0036255 ! response to methylamine
is_a: GO:0071242 ! cellular response to ammonium ion
is_a: GO:0071418 ! cellular response to amine stimulus
created_by: rfoulger
creation_date: 2012-06-15T01:08:00Z

[Term]
id: GO:0036257
name: multivesicular body organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a multivesicular body. A multivesicular body is a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm." [GOC:sart, PMID:11566881]
synonym: "MVB organization" EXACT [GOC:bf]
is_a: GO:0007032 ! endosome organization
created_by: rfoulger
creation_date: 2012-06-15T01:09:53Z

[Term]
id: GO:0036258
name: multivesicular body assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a multivesicular body, a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm." [GOC:sart, PMID:11566881, PMID:19571114]
synonym: "multivesicular body biogenesis" EXACT [PMID:19571114]
synonym: "MVB biogenesis" EXACT [PMID:19571114]
synonym: "MVB formation" EXACT [PMID:19571114]
is_a: GO:0036257 ! multivesicular body organization
is_a: GO:0070925 ! organelle assembly
created_by: rfoulger
creation_date: 2012-06-15T01:12:24Z

[Term]
id: GO:0036259
name: aerobic raffinose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of raffinose that occur in the presence of oxygen." [GOC:al, PMID:10082789]
synonym: "aerobic raffinose breakdown" EXACT [GOC:bf]
synonym: "aerobic raffinose catabolism" EXACT [GOC:bf]
synonym: "aerobic raffinose degradation" EXACT [GOC:bf]
is_a: GO:0034484 ! raffinose catabolic process
created_by: rfoulger
creation_date: 2012-06-15T01:14:51Z

[Term]
id: GO:0036260
name: RNA capping
namespace: biological_process
def: "The sequence of enzymatic reactions by which a cap structure is added to the 5' end of a nascent RNA polymerase II transcript. All RNA polymerase II transcripts receive a 7-methyl-G cap. Then for (at least) small nuclear RNAs (snRNAs) and small nucleolar RNAs (snoRNAs), the7-methyl-G cap is hypermethylated to become a 2,2,7-trimethylguanosine (TMG) cap." [GOC:bf, GOC:krc, GOC:mah, PMID:18775984]
is_a: GO:0006396 ! RNA processing
created_by: rfoulger
creation_date: 2012-06-15T02:10:23Z

[Term]
id: GO:0036261
name: 7-methylguanosine cap hypermethylation
namespace: biological_process
def: "Hypermethylation of the 7-(mono)methylguanosine (m(7)G) cap structure at the 2' position of the guanosine residue to convert a mono-methylated cap to a 2,2,7-trimethylguanosine cap structure. This type of cap modification occurs on small nuclear RNAs (snRNAs) and small nucleolar RNAs (snoRNAs) and is dependent on prior guanine-N7 methylation." [GOC:bf, GOC:BHF, GOC:krc, GOC:mah, GOC:rl, PMID:11983179, PMID:18775984]
synonym: "2,2,7-trimethylguanosine cap formation" EXACT [PMID:11983179]
synonym: "conversion of m(7)G to m(3)G" EXACT [PMID:11983179]
synonym: "hypermethylation of snoRNA cap" NARROW [GOC:bf, GOC:krc, GOC:mah]
synonym: "hypermethylation of snRNA cap" NARROW [GOC:bf, GOC:krc, GOC:mah]
synonym: "m(7)G cap hypermethylation" EXACT [GOC:bf]
synonym: "snoRNA capping" NARROW [GOC:rl]
synonym: "snRNA capping" NARROW [GOC:rl]
synonym: "TMG cap formation" EXACT [PMID:11983179]
is_a: GO:0001510 ! RNA methylation
is_a: GO:0036260 ! RNA capping
created_by: rfoulger
creation_date: 2012-06-15T02:21:39Z

[Term]
id: GO:0036262
name: granulysin production
namespace: biological_process
def: "The appearance of granulysin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv, PR:000008119]
is_a: GO:0002440 ! production of molecular mediator of immune response
created_by: rfoulger
creation_date: 2012-06-18T02:11:15Z

[Term]
id: GO:0036263
name: L-DOPA monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-DOPA + O2 = ? + H2O. This reaction catalyzes the oxygenation of the dopamine precursor L-DOPA, to the corresponding o-quinone." [GOC:sart, PMID:22120533]
is_a: GO:0004097 ! catechol oxidase activity
created_by: rfoulger
creation_date: 2012-06-21T03:57:13Z

[Term]
id: GO:0036264
name: dopamine monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: dopamine + O2 = ? + H2O. This reaction catalyzes the oxygenation of dopamine to the corresponding o-quinone." [GOC:sart, PMID:22120533]
is_a: GO:0004097 ! catechol oxidase activity
created_by: rfoulger
creation_date: 2012-06-21T04:11:30Z

[Term]
id: GO:0036265
name: RNA (guanine-N7)-methylation
namespace: biological_process
def: "The addition of a methyl group to the N7 atom in the base portion of a guanine nucleotide residue in an RNA molecule." [GOC:BHF, GOC:rl]
is_a: GO:0001510 ! RNA methylation
relationship: part_of GO:0009452 ! 7-methylguanosine RNA capping
created_by: rfoulger
creation_date: 2012-06-25T10:28:25Z

[Term]
id: GO:0036266
name: Cdc48p-Npl4p-Vms1p AAA ATPase complex
namespace: cellular_component
def: "A multiprotein ATPase complex involved in the release of polyubiquitinated proteins, including those damaged by oxidative stress, from the outer mitochondria membrane into the cytoplasm where they are presented to the proteasome for proteolysis, a process also referred to as mitochondria-associated degradation (MAD). In budding yeast, this complex includes Cdc48p, Npl4p and Vms1p." [GOC:rn, PMID:21070972, PMID:21936843]
synonym: "Cdc48p-Npl4p-Vms1p complex" EXACT [GOC:rn]
synonym: "Vms1-Cdc48-Npl4 complex" EXACT [GOC:rn]
synonym: "Vms1p-Cdc48p-Npl4p complex" EXACT [GOC:rn]
is_a: GO:0098799 ! outer mitochondrial membrane protein complex
relationship: part_of GO:0005741 ! mitochondrial outer membrane
created_by: rfoulger
creation_date: 2012-06-29T10:57:48Z

[Term]
id: GO:0036267
name: invasive filamentous growth
namespace: biological_process
def: "The growth of colonies in filamentous chains of cells into a substrate." [GOC:di, PMID:22276126]
synonym: "invasive growth" EXACT [GOC:di]
is_a: GO:0070783 ! growth of unicellular organism as a thread of attached cells
created_by: rfoulger
creation_date: 2012-07-02T01:42:24Z

[Term]
id: GO:0036268
name: swimming
namespace: biological_process
def: "Self-propelled movement of an organism from one location to another through water, often by means of active fin movement." [GOC:cvs, PMID:22459995]
comment: For behavioral aspects of swimming, consider instead annotating to 'swimming behavior ; GO:0036269'.
is_a: GO:0040011 ! locomotion
created_by: rfoulger
creation_date: 2012-07-04T10:12:24Z

[Term]
id: GO:0036269
name: swimming behavior
namespace: biological_process
def: "The response to external or internal stimuli that results in the locomotory process of swimming. Swimming is the self-propelled movement of an organism through the water." [GOC:cvs, PMID:16764679]
synonym: "swimming behaviour" EXACT [PMID:16764679]
is_a: GO:0007626 ! locomotory behavior
created_by: rfoulger
creation_date: 2012-07-04T10:14:49Z

[Term]
id: GO:0036270
name: response to diuretic
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diuretic stimulus. A diuretic is an agent that promotes the excretion of urine through its effects on kidney function." [CHEBI:35498, GOC:hp]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
is_a: GO:0042493 ! response to drug
created_by: rfoulger
creation_date: 2012-07-09T01:26:24Z

[Term]
id: GO:0036271
name: response to methylphenidate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylphenidate stimulus." [CHEBI:6887, GOC:hp, Wikipedia:Methylphenidate]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
synonym: "response to MPD" EXACT [CHEBI:6887]
synonym: "response to MPH" EXACT [CHEBI:6887]
synonym: "response to Ritalin" EXACT [CHEBI:6887]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: rfoulger
creation_date: 2012-07-09T01:30:57Z

[Term]
id: GO:0036272
name: response to gemcitabine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gemcitabine stimulus. Gemcitabine is a 2'-deoxycytidine having geminal fluoro substituents in the 2'-position, and is used as a drug in the treatment of various carcinomas." [CHEBI:175901, GOC:hp, Wikipedia:Gemcitabine]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
synonym: "response to 2',2'-difluorodeoxycytidine" EXACT [CHEBI:175901]
synonym: "response to 2'-deoxy-2',2'-difluorocytidine" EXACT [CHEBI:175901]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: rfoulger
creation_date: 2012-07-09T01:36:03Z

[Term]
id: GO:0036273
name: response to statin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a statin stimulus. Statins are organooxygen compounds whose structure is related to compactin (mevastatin) and which may be used as an anticholesteremic drug due its EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitory properties." [GOC:hp]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
synonym: "response to HMG-CoA reductase inhibitor" RELATED [CHEBI:35664]
synonym: "response to hydroxymethylglutaryl-CoA reductase inhibitor" RELATED [CHEBI:35664]
is_a: GO:0010033 ! response to organic substance
is_a: GO:0042493 ! response to drug
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: rfoulger
creation_date: 2012-07-09T01:54:01Z

[Term]
id: GO:0036274
name: response to lapatinib
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lapatinib stimulus." [CHEBI:49603, GOC:hp]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: rfoulger
creation_date: 2012-07-09T02:02:26Z

[Term]
id: GO:0036275
name: response to 5-fluorouracil
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 5-fluorouracil stimulus." [CHEBI:46345, GOC:hp]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
synonym: "response to 5-fluoropyrimidine-2,4(1H,3H)-dione" EXACT [CHEBI:46345]
synonym: "response to fluorouracil" EXACT [CHEBI:46345, GOC:hp]
is_a: GO:0014070 ! response to organic cyclic compound
created_by: rfoulger
creation_date: 2012-07-09T02:08:23Z

[Term]
id: GO:0036276
name: response to antidepressant
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antidepressant stimulus, a mood-stimulating drug." [CHEBI:35469, GOC:hp]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
is_a: GO:0042493 ! response to drug
created_by: rfoulger
creation_date: 2012-07-09T02:12:44Z

[Term]
id: GO:0036277
name: response to anticonvulsant
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anticonvulsant stimulus, a drug used to prevent seizures or reduce their severity." [CHEBI:35623, GOC:hp]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
is_a: GO:0042493 ! response to drug
created_by: rfoulger
creation_date: 2012-07-09T02:40:12Z

[Term]
id: GO:0036278
name: positive regulation of transcription from RNA polymerase II promoter in response to nitrogen starvation
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a deprivation of nitrogen." [GOC:al, PMID:21118960]
is_a: GO:0006995 ! cellular response to nitrogen starvation
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0006995 ! cellular response to nitrogen starvation
intersection_of: positively_regulates GO:0006366 ! transcription from RNA polymerase II promoter
relationship: positively_regulates GO:0006366 ! transcription from RNA polymerase II promoter
created_by: rfoulger
creation_date: 2012-07-11T11:02:55Z

[Term]
id: GO:0036279
name: positive regulation of protein export from nucleus in response to glucose starvation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm in response to deprivation of glucose." [GOC:al, PMID:3541942]
is_a: GO:0042149 ! cellular response to glucose starvation
is_a: GO:0046827 ! positive regulation of protein export from nucleus
created_by: rfoulger
creation_date: 2012-07-11T11:05:20Z

[Term]
id: GO:0036280
name: cellular response to L-canavanine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-canavanine stimulus. L-canavanine is L-homoserine substituted at oxygen with a guanidino (carbamimidamido) group." [CHEBI:609827, GOC:al]
is_a: GO:0071230 ! cellular response to amino acid stimulus
is_a: GO:1901354 ! response to L-canavanine
created_by: rfoulger
creation_date: 2012-07-11T11:09:37Z

[Term]
id: GO:0036281
name: coflocculation
namespace: biological_process
def: "The non-sexual aggregation between single-celled organisms of different species." [GOC:al, PMID:11472912, PMID:11693916]
synonym: "co-flocculation" EXACT [PMID:10689163]
is_a: GO:0044419 ! interspecies interaction between organisms
is_a: GO:0098630 ! aggregation of unicellular organisms
created_by: rfoulger
creation_date: 2012-07-11T01:28:39Z

[Term]
id: GO:0036282
name: coflocculation via protein-carbohydrate interaction
namespace: biological_process
def: "The non-sexual aggregation between single-celled organisms of different species mediated by interaction of a protein in one species and a carbohydrate in the other species. For example, coflocculation between S. pombe and E. coli is mediated by mannose residues in the yeast cell wall interacting with lectin protein in E. coli cell projections." [GOC:al, PMID:11472912, PMID:11693916]
synonym: "coflocculation via lectin-mannose interaction" NARROW [PMID:11693916]
is_a: GO:0036281 ! coflocculation
created_by: rfoulger
creation_date: 2012-07-11T01:30:40Z

[Term]
id: GO:0036283
name: positive regulation of transcription factor import into nucleus in response to oxidative stress
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus under conditions of oxidative stress." [GOC:al, PMID:9585505]
synonym: "positive regulation of transcription factor import into nucleus in response to hydrogen peroxide" RELATED [GOC:al]
is_a: GO:0042993 ! positive regulation of transcription factor import into nucleus
relationship: part_of GO:0034599 ! cellular response to oxidative stress
created_by: rfoulger
creation_date: 2012-07-11T01:46:10Z

[Term]
id: GO:0036284
name: tubulobulbar complex
namespace: cellular_component
def: "Actin-based structures involved in establishing close contact between Sertoli-Sertoli cells or Sertoli-spermatids in the seminiferous tubules of the testes." [GOC:sl, PMID:22510523]
synonym: "TBC" EXACT [GOC:sl, PMID:22510523]
is_a: GO:0043234 ! protein complex
created_by: rfoulger
creation_date: 2012-07-16T10:26:35Z

[Term]
id: GO:0036285
name: SAGA complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a SAGA complex, a SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof." [GOC:mah, PMID:10637607, PMID:22456315]
synonym: "SAGA complex formation" EXACT [GOC:bf]
is_a: GO:0043623 ! cellular protein complex assembly
created_by: rfoulger
creation_date: 2012-07-16T10:30:00Z

[Term]
id: GO:0036286
name: eisosome filament
namespace: cellular_component
def: "A filamentous cortical structure formed, in S. pombe, by the eisosome component Pil1." [GOC:vw, PMID:21900489, PMID:23722945]
synonym: "linear eisosome" EXACT [GOC:vw]
is_a: GO:0043234 ! protein complex
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044448 ! cell cortex part
relationship: part_of GO:0030863 ! cortical cytoskeleton
relationship: part_of GO:0032126 ! eisosome
created_by: rfoulger
creation_date: 2012-07-16T10:52:24Z

[Term]
id: GO:0036287
name: response to iloperidone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iloperidone stimulus." [CHEBI:113949, GOC:hp]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0045472 ! response to ether
is_a: GO:0071867 ! response to monoamine
is_a: GO:1901654 ! response to ketone
created_by: rfoulger
creation_date: 2012-07-16T05:01:29Z

[Term]
id: GO:0036288
name: response to ximelagatran
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ximelagatran stimulus." [CHEBI:578003, GOC:hp]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: rfoulger
creation_date: 2012-07-16T05:03:56Z

[Term]
id: GO:0036289
name: peptidyl-serine autophosphorylation
namespace: biological_process
def: "The phosphorylation by a protein of one or more of its own serine amino acid residues, or a serine residue on an identical protein." [GOC:pm]
synonym: "serine autophosphorylation" EXACT [GOC:bf]
is_a: GO:0018105 ! peptidyl-serine phosphorylation
is_a: GO:0046777 ! protein autophosphorylation
created_by: rfoulger
creation_date: 2012-07-18T10:24:32Z

[Term]
id: GO:0036290
name: protein trans-autophosphorylation
namespace: biological_process
def: "The phosphorylation by a protein of a residue on an identical protein. For example, phosphorylation by the other kinase within a homodimer." [GOC:jsg, PMID:20516151]
synonym: "trans-autophosphorylation" EXACT [GOC:jsg]
is_a: GO:0046777 ! protein autophosphorylation
created_by: rfoulger
creation_date: 2012-07-18T10:27:06Z

[Term]
id: GO:0036291
name: protein cis-autophosphorylation
namespace: biological_process
def: "The phosphorylation by a protein of one or more of its own amino acid residues." [GOC:jsg, PMID:9201908]
synonym: "cis-autophosphorylation" EXACT [GOC:jsg]
is_a: GO:0046777 ! protein autophosphorylation
created_by: rfoulger
creation_date: 2012-07-18T10:27:06Z

[Term]
id: GO:0036292
name: DNA rewinding
namespace: biological_process
def: "The process in which interchain hydrogen bonds between two single-stranded DNA (ssDNA) are reformed to regenerate double-stranded DNA (dsDNA). ssDNA is often bound and stabilized by proteins such as replication protein A (RPA) to form ssDNA bubbles. The bubbles can be rewound by ATP-dependent motors to reform base pairs between strands and thus dsDNA." [PMID:21078962, PMID:22704558, PMID:22705370, PMID:22759634]
synonym: "DNA annealing" RELATED [GOC:sp]
synonym: "RPA-dependent DNA rewinding" NARROW [PMID:21078962]
synonym: "single-stranded DNA bubble rewinding" NARROW [PMID:18974355]
is_a: GO:0032392 ! DNA geometric change
relationship: has_part GO:0000733 ! DNA strand renaturation
created_by: rfoulger
creation_date: 2012-07-18T10:43:41Z

[Term]
id: GO:0036293
name: response to decreased oxygen levels
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen." [GOC:al]
comment: This term should be used when a decrease in oxygen levels is not considered a stress response. For a hypoxic stress response, consider instead 'response to hypoxia ; GO:0001666'.
synonym: "response to lowered oxygen levels" EXACT [GOC:bf]
is_a: GO:0070482 ! response to oxygen levels
created_by: rfoulger
creation_date: 2012-07-20T01:05:46Z

[Term]
id: GO:0036294
name: cellular response to decreased oxygen levels
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen." [GOC:al]
comment: This term should be used when a decrease in oxygen levels is not considered a stress response. For a hypoxic stress response, consider instead 'cellular response to hypoxia ; GO:0071456'.
synonym: "cellular response to lowered oxygen levels" EXACT [GOC:bf]
is_a: GO:0036293 ! response to decreased oxygen levels
is_a: GO:0071453 ! cellular response to oxygen levels
created_by: rfoulger
creation_date: 2012-07-20T01:08:40Z

[Term]
id: GO:0036295
name: cellular response to increased oxygen levels
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting an increase in the level of oxygen." [GOC:al]
comment: This term should be used when an increase in oxygen levels is not considered a stress response. For a hyperoxic stress response, consider instead 'cellular response to hyperoxia ; GO:0071455'.
synonym: "cellular response to raised oxygen levels" EXACT [GOC:bf]
is_a: GO:0036296 ! response to increased oxygen levels
is_a: GO:0071453 ! cellular response to oxygen levels
created_by: rfoulger
creation_date: 2012-07-20T01:09:39Z

[Term]
id: GO:0036296
name: response to increased oxygen levels
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting an increase in the level of oxygen." [GOC:al]
comment: This term should be used when an increase in oxygen levels is not considered a stress response. For a hyperoxic stress response, consider instead 'response to hyperoxia ; GO:0055093.
synonym: "response to raised oxygen levels" EXACT [GOC:bf]
is_a: GO:0070482 ! response to oxygen levels
created_by: rfoulger
creation_date: 2012-07-20T01:10:48Z

[Term]
id: GO:0036297
name: interstrand cross-link repair
namespace: biological_process
def: "Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication." [GOC:vw, PMID:16464006, PMID:22064477]
synonym: "ICL repair" EXACT [PMID:20658649]
is_a: GO:0006281 ! DNA repair
created_by: rfoulger
creation_date: 2012-08-07T11:05:19Z

[Term]
id: GO:0036298
name: recombinational interstrand cross-link repair
namespace: biological_process
def: "Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA by a mechanism that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous region of DNA." [GOC:vw, PMID:20658649]
synonym: "recombination-dependent interstrand cross-link repair" EXACT [GOC:vw]
is_a: GO:0000725 ! recombinational repair
is_a: GO:0036297 ! interstrand cross-link repair
created_by: rfoulger
creation_date: 2012-08-07T11:11:59Z

[Term]
id: GO:0036299
name: non-recombinational interstrand cross-link repair
namespace: biological_process
def: "Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA by a mechanism that does not involve homologous DNA recombination." [GOC:vw, PMID:11154259, PMID:22064477]
synonym: "recombination-independent ICL repair" EXACT [GOC:vw]
synonym: "recombination-independent interstrand cross-link repair" EXACT [GOC:vw]
is_a: GO:0000726 ! non-recombinational repair
is_a: GO:0036297 ! interstrand cross-link repair
created_by: rfoulger
creation_date: 2012-08-07T11:11:59Z

[Term]
id: GO:0036300
name: B cell receptor internalization
namespace: biological_process
def: "A receptor-mediated endocytosis process that results in the movement of a B cell receptor from the plasma membrane to the inside of the cell." [GOC:add, GOC:amm]
synonym: "B cell receptor uptake of antigen" NARROW [PMID:10996020]
synonym: "BCR endocytosis" EXACT [GOC:bf]
synonym: "BCR receptor internalization" EXACT [GOC:amm]
is_a: GO:0031623 ! receptor internalization
created_by: rfoulger
creation_date: 2012-08-07T11:24:20Z

[Term]
id: GO:0036301
name: macrophage colony-stimulating factor production
namespace: biological_process
def: "The appearance of macrophage colony-stimulating factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:vk]
synonym: "M-CSF production" EXACT [GOC:vk]
is_a: GO:0001816 ! cytokine production
created_by: rfoulger
creation_date: 2012-08-07T14:07:13Z

[Term]
id: GO:0036302
name: atrioventricular canal development
namespace: biological_process
def: "The progression of the atrioventricular canal over time, from its formation to the mature structure. The atrioventricular canal is the part of the heart connecting the atrium to the cardiac ventricle." [GOC:BHF, GOC:gr, PMID:14701881, UBERON:0002087, ZFA:0001315]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007507 ! heart development
created_by: rfoulger
creation_date: 2012-08-08T09:55:37Z

[Term]
id: GO:0036303
name: lymph vessel morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of lymph vessels are generated and organized. The lymph vessel is the vasculature carrying lymph." [GOC:BHF, GOC:gr, PMID:18093989]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0001945 ! lymph vessel development
created_by: rfoulger
creation_date: 2012-08-08T10:08:47Z

[Term]
id: GO:0036304
name: umbilical cord morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the umbilical cord are generated and organized. The umbilical cord is an organ or embryonic origin consisting of the 2 umbilical arteries and the one umbilical vein. The umbilical cord connects the cardiovascular system of the fetus to the mother via the placenta." [GOC:BHF, GOC:gr, PMID:15107403]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0061027 ! umbilical cord development
created_by: rfoulger
creation_date: 2012-08-08T10:12:11Z

[Term]
id: GO:0036305
name: ameloblast differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an ameloblast, a cylindrical epithelial cell in the innermost layer of the enamel organ." [CL:0000059]
is_a: GO:0002065 ! columnar/cuboidal epithelial cell differentiation
created_by: rfoulger
creation_date: 2012-08-08T13:49:15Z

[Term]
id: GO:0036306
name: embryonic heart tube elongation
namespace: biological_process
def: "The developmental growth that results in the increase in length of the embryonic heart tube. The embryonic heart tube is an epithelial tube that will give rise to the mature heart." [GOC:BHF, GOC:gr, PMID:15901664]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0035050 ! embryonic heart tube development
created_by: rfoulger
creation_date: 2012-08-08T13:54:37Z

[Term]
id: GO:0036307
name: 23S rRNA (adenine(2030)-N(6))-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + adenine(2030) in 23S rRNA = S-adenosyl-L-homocysteine + rRNA containing N(6)-methyladenine(2030) in 23S rRNA." [GOC:imk, PMID:22847818]
is_a: GO:0008988 ! rRNA (adenine-N6-)-methyltransferase activity
created_by: rfoulger
creation_date: 2012-08-08T14:15:48Z

[Term]
id: GO:0036308
name: 16S rRNA (guanine(1516)-N(2))-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(1516) in 16S rRNA = N(2)-methylguanosine(1516) in 16S rRNA + S-adenosyl-L-homocysteine." [GOC:imk, PMID:22079366]
is_a: GO:0008990 ! rRNA (guanine-N2-)-methyltransferase activity
created_by: rfoulger
creation_date: 2012-08-08T14:17:44Z

[Term]
id: GO:0036309
name: protein localization to M-band
namespace: biological_process
def: "Any process in which a protein is transported to, and/or maintained in, the M band. The M band is the midline of aligned thick filaments in a sarcomere." [GOC:BHF, GOC:rl, PMID:18782775]
synonym: "cellular protein localization to M-band" EXACT [GOC:rl]
synonym: "protein localization to M disc" EXACT [GOC:rl]
synonym: "protein localization to M line" NARROW [GOC:rl]
synonym: "protein localization to mesophragma" EXACT [GOC:rl]
is_a: GO:0033365 ! protein localization to organelle
created_by: rfoulger
creation_date: 2012-08-14T14:02:58Z

[Term]
id: GO:0036310
name: annealing helicase activity
namespace: molecular_function
def: "Catalysis of the ATP-dependent rewinding of single-stranded DNA (ssDNA) to reform base pairs between strands. Often acts on ssDNA bubbles bound by replication protein A (RPA)." [GOC:bf, GOC:sp, PMID:21078962, PMID:22704558, PMID:22705370, PMID:22759634]
synonym: "annealing activity" BROAD [GOC:bf]
synonym: "ATP-dependent DNA annealing activity" RELATED [GOC:sp]
synonym: "nucleoside-triphosphatase activity involved in DNA annealing" EXACT [GOC:bf]
is_a: GO:0017111 ! nucleoside-triphosphatase activity
is_a: GO:0097617 ! annealing activity
intersection_of: GO:0017111 ! nucleoside-triphosphatase activity
intersection_of: part_of GO:0000733 ! DNA strand renaturation
relationship: part_of GO:0000733 ! DNA strand renaturation
created_by: rfoulger
creation_date: 2012-08-14T15:24:29Z

[Term]
id: GO:0036311
name: chitin disaccharide deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-(acetylamino)-4-O-[2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl]-2-deoxy-beta-D-glucopyranose + H2O = 2-(acetylamino)-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-beta-D-glucopyranose + acetate." [EC:3.5.1.105, GOC:imk]
comment: In contrast to EC 3.5.1.41 (chitin deacetylase) this enzyme is specific for the chitin disaccharide.
synonym: "chitin oligosaccharide amidohydrolase activity" EXACT [EC:3.5.1.105]
synonym: "chitin oligosaccharide deacetylase activity" EXACT [EC:3.5.1.105]
synonym: "chitobiose amidohydrolase activity" EXACT [EC:3.5.1.105]
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
created_by: rfoulger
creation_date: 2012-08-15T15:18:09Z

[Term]
id: GO:0036312
name: phosphatidylinositol 3-kinase regulatory subunit binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a regulatory subunit of phosphatidylinositol 3-kinase. The regulatory subunit associates with the catalytic subunit to regulate both its activity and subcellular location." [GOC:bf, PMID:20505341]
synonym: "p85 binding" RELATED [PMID:10627473, PMID:20505341]
synonym: "PI3K regulatory subunit binding" EXACT [GOC:bf]
is_a: GO:0043548 ! phosphatidylinositol 3-kinase binding
created_by: rfoulger
creation_date: 2012-08-16T10:58:45Z

[Term]
id: GO:0036313
name: phosphatidylinositol 3-kinase catalytic subunit binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the catalytic subunit of a phosphatidylinositol 3-kinase. The catalytic subunit catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring." [GOC:bf, PMID:17475214]
synonym: "p110 binding" RELATED [PMID:17475214]
synonym: "PI3K catalytic subunit binding" EXACT [GOC:bf]
is_a: GO:0019900 ! kinase binding
is_a: GO:0043548 ! phosphatidylinositol 3-kinase binding
created_by: rfoulger
creation_date: 2012-08-16T10:58:45Z

[Term]
id: GO:0036314
name: response to sterol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sterol stimulus." [CHEBI:15889, GOC:bf]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033993 ! response to lipid
is_a: GO:0097305 ! response to alcohol
created_by: rfoulger
creation_date: 2012-08-21T14:50:14Z

[Term]
id: GO:0036315
name: cellular response to sterol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sterol stimulus." [CHEBI:15889, GOC:bf]
is_a: GO:0036314 ! response to sterol
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0097306 ! cellular response to alcohol
created_by: rfoulger
creation_date: 2012-08-21T14:51:21Z

[Term]
id: GO:0036316
name: SREBP-SCAP complex retention in endoplasmic reticulum
namespace: biological_process
def: "Any process in which the SREBP-SCAP complex is maintained in the endoplasmic reticulum and prevented from moving elsewhere. The SREBP-SCAP complex is formed by the association of sterol regulatory element binding protein (SREBP) and SREBP-cleavage-activating protein (SCAP). In the absence of sterols, the SREBP-SCAP complex is packaged into COPII vesicles and travels to the Golgi apparatus to be processed. In the presence of sterols, the complex binds ER-resident proteins such as INSIG, which retain the complex in the ER." [GOC:bf, PMID:16525117]
comment: Consider also annotating to the cellular component term: SREBP-SCAP-Insig complex ; GO:0032937.
is_a: GO:0035437 ! maintenance of protein localization in endoplasmic reticulum
is_a: GO:2000639 ! negative regulation of SREBP signaling pathway
relationship: part_of GO:0036315 ! cellular response to sterol
created_by: rfoulger
creation_date: 2012-08-21T14:53:08Z

[Term]
id: GO:0036317
name: tyrosyl-RNA phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a 5' tyrosyl-RNA phosphodiester bond between a protein and RNA. In picornaviruses, this covalent bond connects VPg, a viral-encoded protein essential for RNA replication, to the 5' end of all nascent picornavirus genomes; it is cleaved from viral RNA prior to its engaging in protein synthesis." [GOC:bf, GOC:sp, PMID:21408223, PMID:22908287]
synonym: "unlinkase activity" EXACT [PMID:21408223]
synonym: "uridylylpolynucleotide-(5' P->O)- tyrosine phosphodiesterase activity" EXACT [PMID:21408223]
synonym: "VPg unlinkase activity" EXACT [GOC:sp, PMID:21408223, PMID:22908287]
synonym: "Y-pUpN PDE activity" EXACT [PMID:21408223]
is_a: GO:0008081 ! phosphoric diester hydrolase activity
created_by: rfoulger
creation_date: 2012-08-30T11:08:04Z

[Term]
id: GO:0036318
name: peptide pheromone receptor activity
namespace: molecular_function
def: "Combining with a peptide pheromone, and transmitting the signal across the membrane to initiate a change in cell activity." [CHEBI:38579, GOC:al]
is_a: GO:0008528 ! G-protein coupled peptide receptor activity
is_a: GO:0016503 ! pheromone receptor activity
created_by: rfoulger
creation_date: 2012-08-30T16:45:14Z

[Term]
id: GO:0036319
name: mating-type M-factor pheromone receptor activity
namespace: molecular_function
def: "Combining with the mating-type peptide pheromone M-factor and transmitting the signal across the membrane to initiate a change in cell activity. M-factor is a nine-membered oligopeptide that consists of tyrosyl, threonyl, prolyl, lysyl, valyl, prolyl, tyrosyl, methionyl and methyl S-farnesylcysteinate residues joined in sequence, and is a peptide pheromone released by Schizosaccharomyces pombe cells of the cellular mating type Minus." [CHEBI:64120, GOC:al]
synonym: "M-factor mating pheromone receptor activity" EXACT [PMID:7941744]
synonym: "M-factor receptor activity" EXACT [CHEBI:64120]
is_a: GO:0004932 ! mating-type factor pheromone receptor activity
is_a: GO:0036318 ! peptide pheromone receptor activity
created_by: rfoulger
creation_date: 2012-08-30T16:51:12Z

[Term]
id: GO:0036320
name: mating-type P-factor pheromone receptor activity
namespace: molecular_function
def: "Combining with the mating-type peptide pheromone P-factor and transmitting the signal across the membrane to initiate a change in cell activity. P-factor is a polypeptide of 23 residues, with the sequence Thr-Tyr-Ala-Asp-Phe-Leu-Arg-Ala-Tyr-Gln-Ser-Trp-Asn-Thr-Phe-Val-Asn-Pro-Asp-Arg-Pro-Asn-Leu, and is a peptide pheromone released by Schizosaccharomyces pombe cells of the cellular mating type Plus." [CHEBI:64120, GOC:al]
synonym: "P-factor mating pheromone receptor activity" EXACT [PMID:8314086, PMID:8861202]
synonym: "P-factor receptor activity" EXACT [CHEBI:64121]
is_a: GO:0004932 ! mating-type factor pheromone receptor activity
is_a: GO:0036318 ! peptide pheromone receptor activity
created_by: rfoulger
creation_date: 2012-08-30T16:55:30Z

[Term]
id: GO:0036321
name: ghrelin secretion
namespace: biological_process
def: "The regulated release of ghrelin from a cell. Ghrelin is a 28 amino acid hunger-stimulating peptide hormone." [GOC:cjm, PMID:14610293, Wikipedia:Ghrelin]
synonym: "pancreatic ghrelin secretion" NARROW [GOC:cjm]
is_a: GO:0030072 ! peptide hormone secretion
created_by: rfoulger
creation_date: 2012-09-04T14:16:43Z

[Term]
id: GO:0036322
name: pancreatic polypeptide secretion
namespace: biological_process
def: "The regulated release of pancreatic polypeptide (PP) from a cell. Pancreatic polypeptide is a 36 amino acid polypeptide secreted by islets of Langerhans cells in the pancreas." [GOC:cjm, PMID:12730894, Wikipedia:Pancreatic_polypeptide]
synonym: "PP secretion" NARROW [GOC:cjm]
is_a: GO:0030072 ! peptide hormone secretion
created_by: rfoulger
creation_date: 2012-09-04T14:39:03Z

[Term]
id: GO:0036323
name: vascular endothelial growth factor receptor-1 signaling pathway
namespace: biological_process
def: "Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor-1 (VEGFR-1) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:uh, PR:000007563, Wikipedia:FLT1, Wikipedia:VEGF_receptors]
synonym: "FLT1 signaling pathway" EXACT [GOC:uh, PR:000007563]
synonym: "VEGFR-1 signaling pathway" EXACT [PR:000007563, Reactome:REACT_12556.2, Wikipedia:VEGF_receptors]
synonym: "VEGFR1 signaling pathway" EXACT [Reactome:REACT_12556.2]
xref: Reactome:REACT_12556.2 "VEGF-A,B,PLGF bind to VEGFR1 leading to receptor dimerization (Homo sapiens)"
is_a: GO:0048010 ! vascular endothelial growth factor receptor signaling pathway
created_by: rfoulger
creation_date: 2012-09-04T15:11:21Z

[Term]
id: GO:0036324
name: vascular endothelial growth factor receptor-2 signaling pathway
namespace: biological_process
def: "Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor-2 (VEGFR-2) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:uh, PMID:12967471, PR:000002112, Wikipedia:Kinase_insert_domain_receptor, Wikipedia:VEGF_receptors]
synonym: "FLK-1 signaling pathway" EXACT [PR:000002112]
synonym: "KDR signaling pathway" EXACT [GOC:uh, PR:000002112, Wikipedia:Kinase_insert_domain_receptor]
synonym: "VEGFR-2 signaling pathway" EXACT [PR:000002112, Reactome:REACT_12440.2, Wikipedia:Kinase_insert_domain_receptor, Wikipedia:VEGF_receptors]
synonym: "VEGFR2 signaling pathway" EXACT [Reactome:REACT_12440.2]
xref: Reactome:REACT_12440.2 "VEGF-A,C,D,E bind to VEGFR2 leading to receptor dimerization (Homo sapiens)"
is_a: GO:0048010 ! vascular endothelial growth factor receptor signaling pathway
created_by: rfoulger
creation_date: 2012-09-04T15:15:40Z

[Term]
id: GO:0036325
name: vascular endothelial growth factor receptor-3 signaling pathway
namespace: biological_process
def: "Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor-3 (VEGFR-3) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:uh, PR:000007565, Wikipedia:VEGF_receptors, Wikipedia:VEGFR3]
synonym: "FLT4 signaling pathway" EXACT [GOC:uh, PR:000007565]
synonym: "VEGFR-3 signaling pathway" EXACT [Reactome:REACT_12533.2, Wikipedia:VEGF_receptors]
synonym: "VEGFR3 signaling pathway" EXACT [Reactome:REACT_12440.2, Wikipedia:VEGFR3]
xref: Reactome:REACT_12533.2 "VEGF-C,D bind to VEGFR3 leading to receptor dimerization (Homo sapiens)"
is_a: GO:0048010 ! vascular endothelial growth factor receptor signaling pathway
created_by: rfoulger
creation_date: 2012-09-04T15:25:13Z

[Term]
id: GO:0036326
name: VEGF-A-activated receptor activity
namespace: molecular_function
def: "Combining with vascular endothelial growth factor A (VEGF-A) and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:bf, GOC:signaling, PR:000017284, Wikipedia:VEGF-A]
synonym: "vascular endothelial growth factor A-activated receptor activity" EXACT [GOC:bf, PR:000017284]
is_a: GO:0005021 ! vascular endothelial growth factor-activated receptor activity
created_by: rfoulger
creation_date: 2012-09-04T15:33:19Z

[Term]
id: GO:0036327
name: VEGF-B-activated receptor activity
namespace: molecular_function
def: "Combining with vascular endothelial growth factor B (VEGF-B) and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:bf, GOC:signaling, PR:000003096, Wikipedia:VEGF-B]
synonym: "vascular endothelial growth factor B-activated receptor activity" EXACT [GOC:bf, PR:000003096]
is_a: GO:0005021 ! vascular endothelial growth factor-activated receptor activity
created_by: rfoulger
creation_date: 2012-09-04T15:36:05Z

[Term]
id: GO:0036328
name: VEGF-C-activated receptor activity
namespace: molecular_function
def: "Combining with vascular endothelial growth factor C (VEGF-C) and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:bf, GOC:signaling, PR:000017285, Wikipedia:VEGF-C]
synonym: "vascular endothelial growth factor C-activated receptor activity" EXACT [GOC:bf, PR:000017285]
synonym: "VEGFC-activated receptor activity" EXACT [PR:000017285]
is_a: GO:0005021 ! vascular endothelial growth factor-activated receptor activity
created_by: rfoulger
creation_date: 2012-09-04T15:37:17Z

[Term]
id: GO:0036329
name: VEGF-D-activated receptor activity
namespace: molecular_function
def: "Combining with vascular endothelial growth factor D (VEGF-D) and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:bf, GOC:signaling, PR:000007520, Wikipedia:VEGF-D]
synonym: "C-fos induced growth factor receptor activity" EXACT [PR:000007520, Wikipedia:VEGF-D]
synonym: "vascular endothelial growth factor D-activated receptor activity" EXACT [GOC:bf, PR:000007520]
synonym: "VEGFD-activated receptor activity" EXACT [PR:000017285]
is_a: GO:0005021 ! vascular endothelial growth factor-activated receptor activity
created_by: rfoulger
creation_date: 2012-09-04T15:38:31Z

[Term]
id: GO:0036330
name: VEGF-E-activated receptor activity
namespace: molecular_function
def: "Combining with vascular endothelial growth factor E (VEGF-E) and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:bf, GOC:signaling, PMID:19909239]
synonym: "vascular endothelial growth factor E-activated receptor activity" EXACT [PMID:19909239]
is_a: GO:0005021 ! vascular endothelial growth factor-activated receptor activity
relationship: part_of GO:0036324 ! vascular endothelial growth factor receptor-2 signaling pathway
created_by: rfoulger
creation_date: 2012-09-04T15:41:31Z

[Term]
id: GO:0036331
name: avascular cornea development in camera-type eye
namespace: biological_process
def: "The progression of an avascular cornea over time, from its formation to the mature structure. Corneal avascularity (the absence of blood vessels in the cornea) is required for optical clarity and optimal vision. Avascular corneas are present in most animals, except Manatees." [GOC:uh, PMID:16849433, PMID:17051153]
synonym: "avascular cornea development" EXACT [GOC:bf]
is_a: GO:0061303 ! cornea development in camera-type eye
created_by: rfoulger
creation_date: 2012-09-05T09:07:14Z

[Term]
id: GO:0036332
name: placental growth factor-activated receptor activity
namespace: molecular_function
def: "Combining with placental growth factor (PlGF) and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:uh, PMID:12871269, PMID:7929268, PR:000012605, Wikipedia:Placental_growth_factor]
synonym: "placental growth factor receptor activity" EXACT [GOC:bf]
synonym: "PlGF receptor activity" RELATED [PMID:12871269]
synonym: "PlGF-activated receptor activity" EXACT [GOC:uh, PMID:12871269]
is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity
relationship: part_of GO:0036323 ! vascular endothelial growth factor receptor-1 signaling pathway
created_by: rfoulger
creation_date: 2012-09-05T09:34:37Z

[Term]
id: GO:0036333
name: hepatocyte homeostasis
namespace: biological_process
def: "Any biological process involved in the maintenance of the steady-state number of hepatocytes within a population of cells. Hepatocytes are specialized epithelial cells of the liver that are organized into interconnected plates called lobules." [CL:0000182, GOC:nhn, PMID:19878874]
is_a: GO:0048872 ! homeostasis of number of cells
created_by: rfoulger
creation_date: 2012-09-05T10:17:07Z

[Term]
id: GO:0036334
name: epidermal stem cell homeostasis
namespace: biological_process
def: "Any biological process involved in the maintenance of the steady-state number of epidermal stem cells within a population of cells." [CL:1000428, GOC:nhn, PMID:17666529]
is_a: GO:0048872 ! homeostasis of number of cells
created_by: rfoulger
creation_date: 2012-09-05T10:21:23Z

[Term]
id: GO:0036335
name: intestinal stem cell homeostasis
namespace: biological_process
def: "Any biological process involved in the maintenance of the steady-state number of intestinal stem cells within a population of cells." [GOC:nhn, PMID:22042863]
is_a: GO:0048872 ! homeostasis of number of cells
created_by: rfoulger
creation_date: 2012-09-05T10:23:41Z

[Term]
id: GO:0036336
name: dendritic cell migration
namespace: biological_process
def: "The movement of a dendritic cell within or between different tissues and organs of the body." [CL:0000451, GOC:nhn, PMID:19339990]
is_a: GO:0050900 ! leukocyte migration
created_by: rfoulger
creation_date: 2012-09-05T10:24:46Z

[Term]
id: GO:0036337
name: Fas signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of a ligand to the receptor Fas on the surface of the cell, and ending with regulation of a downstream cellular process, e.g. transcription. Fas is a death domain-containing member of the tumor necrosis factor receptor (TNFR) superfamily." [GOC:nhn, PMID:12040174, Wikipedia:Fas_receptor]
synonym: "Apo-1 signaling pathway" EXACT [PMID:12040174]
synonym: "CD95 signaling pathway" EXACT [PMID:12040174]
synonym: "FAS ligand-Fas signaling pathway" NARROW [PMID:12040174]
synonym: "Fas receptor signaling pathway" EXACT [Wikipedia:Fas_receptor]
synonym: "Fas-FasL signaling pathway" NARROW [GOC:bf]
synonym: "FasL signaling pathway" RELATED [Wikipedia:Fas_ligand]
synonym: "FasR signaling pathway" EXACT [Wikipedia:Fas_receptor]
is_a: GO:0007166 ! cell surface receptor signaling pathway
created_by: rfoulger
creation_date: 2012-09-05T10:28:11Z

[Term]
id: GO:0036338
name: viral membrane
namespace: cellular_component
def: "The lipid bilayer of a virion, a complete fully infectious extracellular virus particle." [GOC:bm]
is_a: GO:0044423 ! virion part
created_by: rfoulger
creation_date: 2012-09-07T13:28:21Z

[Term]
id: GO:0036339
name: lymphocyte adhesion to endothelial cell of high endothelial venule
namespace: biological_process
def: "The attachment of a lymphocyte to an endothelial cell of a high endothelial venule (HEV) via adhesion molecules. A HEV cell is an endothelial cell that is cuboidal, expresses leukocyte-specific receptors, and allows for passage of lymphocytes into bloodstream." [CL:0000542, CL:0002652, GOC:nhn, PMID:19339990, PMID:7679710, Wikipedia:High_endothelial_venules]
comment: For the transition of leukocytes from rolling to adhered, consider instead annotating to 'leukocyte adhesive activation ; GO:0050902'.
synonym: "lymphocyte adhesion to HEV cell" EXACT [PMID:7679710, Wikipedia:High_endothelial_venules]
synonym: "lymphocyte adhesion to high endothelial venule" EXACT [GOC:nhn]
is_a: GO:0061756 ! leukocyte adhesion to vascular endothelial cell
created_by: rfoulger
creation_date: 2012-09-10T16:00:23Z

[Term]
id: GO:0036340
name: chitin-based cuticle sclerotization by biomineralization
namespace: biological_process
def: "The process of hardening a chitin-based cuticle by mineral incorporation. For example, the cuticle of crustaceans is hardened by the incorporation of calcium carbonate." [GOC:sart]
synonym: "chitin-based cuticle hardening by biomineralisation" EXACT [GOC:bf]
is_a: GO:0007593 ! chitin-based cuticle sclerotization
is_a: GO:0031214 ! biomineral tissue development
created_by: rfoulger
creation_date: 2012-09-11T13:50:04Z

[Term]
id: GO:0036341
name: chitin-based cuticle sclerotization by protein cross-linking
namespace: biological_process
def: "The process of hardening of a chitin-based cuticle by protein cross-linking, and the incorporation of phenolic precursors. This mechanism of cuticle hardening occurs in insects and is usually accompanied by darkening of the cuticle." [GOC:bf, GOC:sart]
synonym: "chitin-based cuticle sclerotization by protein cross-linking and cuticle tanning" NARROW [GOC:bf, GOC:dos, GOC:sart]
is_a: GO:0007593 ! chitin-based cuticle sclerotization
created_by: rfoulger
creation_date: 2012-09-11T13:51:46Z

[Term]
id: GO:0036342
name: post-anal tail morphogenesis
namespace: biological_process
def: "The process in which a post-anal tail is generated and organized. A post-anal tail is a muscular region of the body that extends posterior to the anus. The post-anal tail may aid locomotion and balance." [GOC:bf, GOC:kmv, Wikipedia:Chordate]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
created_by: rfoulger
creation_date: 2012-09-11T13:54:49Z

[Term]
id: GO:0036343
name: psychomotor behavior
namespace: biological_process
def: "The specific behavior of an organism that combines cognitive functions and physical movement. For example, driving a car, throwing a ball, or playing a musical instrument." [GOC:nhn, GOC:pr, PMID:17159989, Wikipedia:Psychomotor_learning]
is_a: GO:0061744 ! motor behavior
created_by: rfoulger
creation_date: 2012-09-11T14:32:06Z

[Term]
id: GO:0036344
name: platelet morphogenesis
namespace: biological_process
def: "Generation and organization of a platelet, a non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation." [CL:0000233, GOC:BHF, GOC:vk]
is_a: GO:0000904 ! cell morphogenesis involved in differentiation
created_by: rfoulger
creation_date: 2012-09-11T15:15:35Z

[Term]
id: GO:0036345
name: platelet maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a platelet to attain its fully functional state. A platelet is a non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation." [CL:0000233, GOC:BHF, GOC:vk]
is_a: GO:0048469 ! cell maturation
created_by: rfoulger
creation_date: 2012-09-11T15:23:11Z

[Term]
id: GO:0036346
name: cellular response to L-cysteine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-cysteine stimulus. L-cysteine is an optically active form of cysteine having L-configuration." [CHEBI:17561, GOC:al]
is_a: GO:0071230 ! cellular response to amino acid stimulus
is_a: GO:1901367 ! response to L-cysteine
created_by: rfoulger
creation_date: 2012-09-18T14:21:54Z

[Term]
id: GO:0036347
name: glutathione import into cell
namespace: biological_process
def: "The directed movement of glutathione from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [GOC:al]
synonym: "glutathione uptake" EXACT [GOC:bf]
is_a: GO:0034635 ! glutathione transport
is_a: GO:0098657 ! import into cell
created_by: rfoulger
creation_date: 2012-09-18T14:29:19Z

[Term]
id: GO:0036348
name: hydantoin racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-5-monosubstituted hydantoin = L-5-monosubstituted hydantoin." [EC:5.1.99.5, InterPro:IPR015942]
xref: EC:5.1.99.5
xref: KEGG:R09704
xref: MetaCyc:RXN-9781
is_a: GO:0016854 ! racemase and epimerase activity
created_by: rfoulger
creation_date: 2012-09-19T10:47:56Z

[Term]
id: GO:0036349
name: galactose-specific flocculation
namespace: biological_process
def: "The non-sexual aggregation of single-celled organisms mediated by the binding of cell wall proteins on one cell to galactose residues on the other." [GOC:vw, PMID:22098069]
is_a: GO:0000501 ! flocculation via cell wall protein-carbohydrate interaction
relationship: has_part GO:0005534 ! galactose binding
created_by: rfoulger
creation_date: 2012-09-19T10:56:16Z

[Term]
id: GO:0036350
name: mannose-specific flocculation
namespace: biological_process
def: "The non-sexual aggregation of single-celled organisms mediated by the binding of cell wall proteins on one cell to mannose residues on the other." [GOC:vw, PMID:9851992]
is_a: GO:0000501 ! flocculation via cell wall protein-carbohydrate interaction
relationship: has_part GO:0005537 ! mannose binding
created_by: rfoulger
creation_date: 2012-09-19T10:57:34Z

[Term]
id: GO:0036351
name: histone H2A-K13 ubiquitination
namespace: biological_process
def: "The modification of histone H2A by addition of ubiquitin group at lysine 13 (H2A-K13) in metazoans, and at the equivalent residue in other organisms. Monoubiquitin is first attached to H2A-K13 and K63-linked ubiquitin chains are then extended from this monoubiquitin." [GOC:sp, PMID:22713238, PMID:22980979]
synonym: "histone H2A ubiquitination (H2A-K13)" EXACT [GOC:sp]
is_a: GO:0033522 ! histone H2A ubiquitination
created_by: rfoulger
creation_date: 2012-09-19T11:48:05Z

[Term]
id: GO:0036352
name: histone H2A-K15 ubiquitination
namespace: biological_process
def: "The modification of histone H2A by addition of ubiquitin group at lysine 15 (H2A-K15) in metazoans, and at the equivalent residue in other organisms. Monoubiquitin is first attached to H2A-K15 and K63-linked ubiquitin chains are then extended from this monoubiquitin." [GOC:sp, PMID:22713238, PMID:22980979]
synonym: "histone H2A ubiquitination (H2A-K15)" EXACT [GOC:sp]
is_a: GO:0033522 ! histone H2A ubiquitination
created_by: rfoulger
creation_date: 2012-09-19T11:49:03Z

[Term]
id: GO:0036353
name: histone H2A-K119 monoubiquitination
namespace: biological_process
def: "The modification of histone H2A by addition of a single ubiquitin group to lysine-119 (H2A- K119) in metazoans, and at the equivalent residue in other organisms." [GOC:sp, PMID:15386022]
synonym: "histone H2A monoubiquitination (H2A-K119)" EXACT [GOC:sp]
is_a: GO:0035518 ! histone H2A monoubiquitination
created_by: rfoulger
creation_date: 2012-09-19T11:52:25Z

[Term]
id: GO:0036354
name: 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide a dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide a = bacteriochlorophyllide a + 2 H+." [GOC:crds, InterPro:IPR005903, MetaCyc:RXN-8787, PMID:8437569]
xref: MetaCyc:RXN-8787
is_a: GO:0016491 ! oxidoreductase activity
relationship: part_of GO:0030494 ! bacteriochlorophyll biosynthetic process
created_by: rfoulger
creation_date: 2012-09-19T14:46:31Z

[Term]
id: GO:0036355
name: 2-iminoacetate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tyrosine + S-adenosyl-L-methionine + reduced acceptor = 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + acceptor + 2 H+." [EC:4.1.99.19, GOC:crds, MetaCyc:RXN-11319, PMID:17403671]
xref: EC:4.1.99.19
xref: MetaCyc:RXN-11319
xref: RHEA:26364
is_a: GO:0016830 ! carbon-carbon lyase activity
relationship: part_of GO:0009228 ! thiamine biosynthetic process
created_by: rfoulger
creation_date: 2012-09-19T14:52:51Z

[Term]
id: GO:0036356
name: cyclic 2,3-diphosphoglycerate synthetase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-diphosphoglycerate (DPG) + ATP = cyclic 2,3-diphosphoglycerate (cDPG) + ADP + phosphate." [GOC:crds, PMID:2226838, PMID:8320225, PMID:9811660]
comment: This reaction is the intramolecular cyclization of 2,3-diphosphoglycerate to cyclic 2,3-diphosphoglycerate and is the second step in the biosynthesis of cyclic 2,3-diphosphoglycerate (cDPG).
synonym: "cDPGS activity" EXACT [PMID:9811660]
synonym: "CPGS activity" EXACT [GOC:bf]
xref: EC:4.6.1.-
is_a: GO:0009975 ! cyclase activity
relationship: part_of GO:1901369 ! cyclic 2,3-bisphospho-D-glycerate biosynthetic process
created_by: rfoulger
creation_date: 2012-09-19T14:59:19Z

[Term]
id: GO:0036357
name: 2-phosphoglycerate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-phosphoglycerate + ATP = 2,3-diphosphoglycerate + ADP." [GOC:bf, InterPro:IPR020872, PMID:2226838, PMID:8159166]
comment: This reaction is the first step in the biosynthesis of cyclic 2,3-diphosphoglycerate (cDPG).
synonym: "2PGK activity" EXACT [GOC:bf]
xref: EC:2.7.2.-
is_a: GO:0016301 ! kinase activity
relationship: part_of GO:1901369 ! cyclic 2,3-bisphospho-D-glycerate biosynthetic process
created_by: rfoulger
creation_date: 2012-09-19T15:06:25Z

[Term]
id: GO:0036358
name: lipoteichoic acid D-alanylation
namespace: biological_process
def: "The formation of a D-alanyl ester of lipoteichoic acid by transfer of D-Ala onto a membrane-associated lipoteichoic acid (LTA)." [GOC:crds, PMID:22750871, PMID:8682792]
synonym: "D-alanyl lipoteichoic acid formation" EXACT [PMID:8682792]
synonym: "D-alanyl LTA formation" EXACT [PMID:8682792]
synonym: "LTA D-alanylation" EXACT [PMID:22750871]
is_a: GO:0070400 ! teichoic acid D-alanylation
created_by: rfoulger
creation_date: 2012-09-19T15:09:05Z

[Term]
id: GO:0036359
name: renal potassium excretion
namespace: biological_process
def: "The elimination by an organism of potassium in the urine." [GOC:gap, PMID:15034090, PMID:16014448]
synonym: "renal K(+) excretion" EXACT [PMID:16014448]
synonym: "renal K+ elimination" EXACT [PMID:15034090]
synonym: "renal potassium ion excretion" EXACT [GOC:bf]
is_a: GO:0003014 ! renal system process
is_a: GO:0007588 ! excretion
created_by: rfoulger
creation_date: 2012-09-20T11:10:47Z

[Term]
id: GO:0036360
name: sorocarp stalk morphogenesis
namespace: biological_process
def: "The process in which the sorocarp stalk is generated and organized. The sorocarp stalk is a tubular structure that consists of cellulose-covered cells stacked on top of each other and surrounded by an acellular stalk tube composed of cellulose and glycoprotein. An example of this process is found in Dictyostelium discoideum." [DDANAT:0000068, GOC:pf, PMID:22902739]
synonym: "fruiting body stalk morphogenesis" BROAD [DDANAT:0000068]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0031150 ! sorocarp stalk development
relationship: part_of GO:0031288 ! sorocarp morphogenesis
created_by: rfoulger
creation_date: 2012-09-20T11:21:30Z

[Term]
id: GO:0036361
name: racemase activity, acting on amino acids and derivatives
namespace: molecular_function
def: "Catalysis of the interconversion of the two enantiomers of a chiral amino acid or amino acid derivative." [GOC:crds]
is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives
created_by: rfoulger
creation_date: 2012-09-21T11:13:47Z

[Term]
id: GO:0036362
name: ascus membrane
namespace: cellular_component
def: "A double layer of lipid molecules that surrounds an ascus, a capsule containing the sexual spores in some fungi." [GOC:mcc, GOC:vw, PMID:21900489]
is_a: GO:0016020 ! membrane
created_by: rfoulger
creation_date: 2012-09-21T11:21:41Z

[Term]
id: GO:0036363
name: transforming growth factor beta activation
namespace: biological_process
def: "The release of transforming growth factor beta (TGF-beta) from its latent state. TGF-beta is secreted as part of a large latent complex (LLC) that is targeted to the extracellular matrix. Release of TGFbeta from its latent state is required for TGFbeta to bind to its receptors, and can occur by a variety of mechanisms." [GOC:bf, GOC:sl, PMID:12482908, PMID:9170210]
synonym: "L-TGF-beta activation" EXACT [PMID:2070685]
synonym: "latent TGF-beta activation" EXACT [PMID:2070685]
synonym: "TGF-B activation" EXACT [GOC:sl]
synonym: "TGF-beta activation" EXACT [PR:000000046]
synonym: "TGFB activation" EXACT [GOC:sl]
synonym: "TGFbeta activation" EXACT [GOC:bf]
is_a: GO:0044707 ! single-multicellular organism process
relationship: part_of GO:0071604 ! transforming growth factor beta production
created_by: rfoulger
creation_date: 2012-09-24T10:06:56Z

[Term]
id: GO:0036364
name: transforming growth factor beta1 activation
namespace: biological_process
def: "The release of transforming growth factor beta1 (TGF-beta1) from its latent state." [GOC:sl, PMID:12482908, PMID:9170210]
synonym: "L-TGF-beta 1 activation" EXACT [PMID:2070685]
synonym: "latent-TGF-beta1 activation" EXACT [PMID:19439069]
synonym: "TGF-beta 1 activation" EXACT [PR:000000182]
synonym: "TGFB1 activation" EXACT [PR:000000182]
synonym: "TGFbeta 1 activation" EXACT [GOC:bf]
synonym: "transforming growth factor-beta1 activation" EXACT [PMID:19513812]
is_a: GO:0036363 ! transforming growth factor beta activation
relationship: part_of GO:0032905 ! transforming growth factor beta1 production
created_by: rfoulger
creation_date: 2012-09-24T10:09:02Z

[Term]
id: GO:0036365
name: transforming growth factor beta2 activation
namespace: biological_process
def: "The release of transforming growth factor beta 2 (TGF-beta2) from its latent state." [GOC:sl, PMID:12482908, PMID:9170210]
synonym: "TGF-beta 2 activation" EXACT [PR:000000183]
synonym: "TGFB2 activation" EXACT [PR:000000183]
synonym: "TGFbeta 2 activation" EXACT [GOC:bf]
is_a: GO:0036363 ! transforming growth factor beta activation
relationship: part_of GO:0032906 ! transforming growth factor beta2 production
created_by: rfoulger
creation_date: 2012-09-24T10:15:11Z

[Term]
id: GO:0036366
name: transforming growth factor beta3 activation
namespace: biological_process
def: "The release of transforming growth factor beta 3 (TGF-beta3) from its latent state." [GOC:sl, PMID:12482908, PMID:9170210]
synonym: "TGF-beta 3 activation" EXACT [PR:000000184]
synonym: "TGFB3 activation" EXACT [PR:000000184]
synonym: "TGFbeta 3 activation" EXACT [GOC:bf]
is_a: GO:0036363 ! transforming growth factor beta activation
relationship: part_of GO:0032907 ! transforming growth factor beta3 production
created_by: rfoulger
creation_date: 2012-09-24T10:16:05Z

[Term]
id: GO:0036367
name: light adaption
namespace: biological_process
def: "The ability of a photoreceptor to adjust to varying levels of light." [GOC:gap, PMID:16039565]
comment: Light adaptation is usually a combination of cell desensitization and response acceleration.
is_a: GO:0009642 ! response to light intensity
created_by: rfoulger
creation_date: 2012-09-26T13:28:14Z

[Term]
id: GO:0036368
name: cone photoresponse recovery
namespace: biological_process
def: "The processes required for a cone photoreceptor to recover, following light activation, so that it can respond to a subsequent light stimulus. Cone recovery requires the shutoff of active participants in the phototransduction cascade, including the visual pigment and downstream signal transducers." [GOC:gap, PMID:16039565, PMID:22802362]
synonym: "cone phototransduction termination" RELATED [GOC:bf]
synonym: "cone response recovery" EXACT [PMID:12732716]
is_a: GO:0009416 ! response to light stimulus
created_by: rfoulger
creation_date: 2012-09-26T14:35:20Z

[Term]
id: GO:0036369
name: transcription factor catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a sequence-specific DNA binding transcription factor by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:al, GOC:vw, PMID:22833559]
synonym: "proteasome-mediated transcription factor catabolism" EXACT [GOC:bf]
synonym: "sequence-specific DNA binding transcription factor catabolic process" EXACT [GOC:bf]
synonym: "transcription factor breakdown" EXACT [GOC:bf]
synonym: "transcription factor catabolism" EXACT [GOC:bf]
synonym: "transcription factor degradation" EXACT [PMID:22833559]
is_a: GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process
created_by: rfoulger
creation_date: 2012-10-05T10:53:55Z

[Term]
id: GO:0036370
name: D-alanyl carrier activity
namespace: molecular_function
def: "Accepts activated D-alanine and subsequently transfers D-alanine onto a teichoic acid acceptor molecule. The carrier protein provides an essential link between the D-alanine-D-alanyl carrier protein ligase and the incorporation of D-alanine into the substrate." [GOC:crds, PMID:11222605, PMID:22750871, PMID:8682792]
synonym: "D-alanyl carrier protein" RELATED [GOC:crds, PMID:11222605]
is_a: GO:0003674 ! molecular_function
relationship: part_of GO:0070400 ! teichoic acid D-alanylation
created_by: rfoulger
creation_date: 2012-10-08T10:30:33Z

[Term]
id: GO:0036371
name: protein localization to T-tubule
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, the T-tubule. The T-tubule is an invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril." [GOC:BHF, GOC:rl, PMID:16292983]
synonym: "protein localisation to T-tubule" EXACT [GOC:rl]
synonym: "protein localization to T tubule" EXACT [GOC:rl]
synonym: "protein localization to transverse tubule" EXACT [GOC:rl]
is_a: GO:0072659 ! protein localization to plasma membrane
created_by: rfoulger
creation_date: 2012-10-08T17:10:29Z

[Term]
id: GO:0036372
name: opsin transport
namespace: biological_process
def: "The directed movement of an opsin (a G-protein coupled receptor of photoreceptor cells) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:atm, PMID:20238016, PMID:22855808]
synonym: "ciliary transport of opsin" NARROW [GOC:20238016]
is_a: GO:0015031 ! protein transport
created_by: rfoulger
creation_date: 2013-04-23T09:26:29Z

[Term]
id: GO:0036373
name: L-fucose mutarotase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-L-fucose = beta-L-fucose." [GOC:crds, PMID:15060078, RHEA:25583]
synonym: "alpha-L-fucose 1-epimerase activity" EXACT [EC:5.1.3.-]
synonym: "fucose 1-epimerase activity" EXACT [EC:5.1.3.-]
synonym: "type-2 mutarotase activity" EXACT [EC:5.1.3.-]
xref: EC:5.1.3.-
xref: MetaCyc:RXN0-5298
xref: RHEA:25583
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives
created_by: rfoulger
creation_date: 2013-05-07T09:51:06Z

[Term]
id: GO:0036374
name: glutathione hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate." [EC:3.4.19.13, GOC:imk]
comment: For gamma-glutamyltransferase activity (EC:2.3.2.2) see GO:0003840.
synonym: "gamma-glutamyltranspeptidase activity" EXACT [EC:3.4.19.13]
synonym: "glutathionase activity" EXACT [EC:3.4.19.13]
xref: EC:3.4.19.13
xref: KEGG:R00494
xref: MetaCyc:RXN-12618
xref: RHEA:28810
is_a: GO:0008242 ! omega peptidase activity
created_by: rfoulger
creation_date: 2013-05-07T09:58:07Z

[Term]
id: GO:0036375
name: Kibra-Ex-Mer complex
namespace: cellular_component
def: "An apical protein complex that contains the proteins Kibra, Expanded and Merlin (Mer), or orthologs thereof. In humans, the complex contains KIBRA, FDM6 and NF2." [PMID:20159598]
synonym: "Kbr, Ex and Mer complex" EXACT [PMID:20159598]
synonym: "KEM complex" EXACT [PMID:20159598]
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0045177 ! apical part of cell
created_by: rfoulger
creation_date: 2013-05-07T10:05:15Z

[Term]
id: GO:0036376
name: sodium ion export from cell
namespace: biological_process
def: "The directed movement of sodium ions out of a cell." [GOC:al, PMID:14674689]
is_a: GO:0071436 ! sodium ion export
created_by: rfoulger
creation_date: 2013-05-07T15:06:26Z

[Term]
id: GO:0036377
name: arbuscular mycorrhizal association
namespace: biological_process
def: "A form of mutualism between a fungus and the roots of a vascular plant, where hyphae of the fungus penetrate the plant cell wall and invaginate its cell membrane. Once inside, the fungus forms highly branched structures for nutrient exchange with the plant called arbuscules. Aids in the acquisition by the plant of nutrients such as phosphorus from the soil." [GOC:sk, Wikipedia:Arbuscular_mycorrhiza]
synonym: "arbuscular mycorrhizae formation" EXACT [Wikipedia:Arbuscular_mycorrhiza]
synonym: "arbuscular mycorrhizal symbiosis" RELATED [Wikipedia:Arbuscular_mycorrhiza]
synonym: "arbuscular mycorrhizas formation" EXACT [Wikipedia:Arbuscular_mycorrhiza]
is_a: GO:0085030 ! mutualism
created_by: rfoulger
creation_date: 2013-05-07T15:07:32Z

[Term]
id: GO:0036378
name: calcitriol biosynthetic process from calciol
namespace: biological_process
def: "Conversion of vitamin D3 from its largely inactive form (calciol, also called cholecalciferol) into a hormonally active form (calcitriol). Conversion requires 25-hydroxylation of calciol in the liver to form calcidiol, and subsequent 1,alpha-hydroxylation of calcidiol in the kidney to form calcitriol." [GOC:BHF, GOC:rl, PMID:17426122, PMID:20511049]
synonym: "1alpha,25(OH)2D3 biosynthesis" BROAD [CHEBI:17823]
synonym: "1alpha,25-dihydroxycholecalciferol biosynthesis" BROAD [CHEBI:17823]
synonym: "1alpha,25-dihydroxyvitamin D3 biosynthesis" BROAD [CHEBI:17823]
synonym: "calcitriol biosynthesis from calciol" EXACT [GOC:bf]
synonym: "vitamin D3 activation" EXACT [GOC:bf, PMID:20506379]
is_a: GO:0042368 ! vitamin D biosynthetic process
is_a: GO:0044108 ! cellular alcohol biosynthetic process
is_a: GO:0046173 ! polyol biosynthetic process
is_a: GO:0070640 ! vitamin D3 metabolic process
created_by: rfoulger
creation_date: 2013-05-15T11:46:08Z

[Term]
id: GO:0036379
name: myofilament
namespace: cellular_component
def: "Any of the smallest contractile units of a myofibril (striated muscle fiber)." [Wikipedia:Myofilament]
synonym: "striated muscle filament" EXACT [GOC:bf]
is_a: GO:0044449 ! contractile fiber part
relationship: part_of GO:0030016 ! myofibril
created_by: rfoulger
creation_date: 2013-05-22T14:39:06Z

[Term]
id: GO:0036380
name: UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-alpha-D-glucosamine + ditrans,octacis-undecaprenyl phosphate = UMP + N-acetyl-alpha-D-glucosaminyldiphospho-ditrans,octacis-undecaprenol." [EC:2.7.8.33, GOC:rs]
synonym: "GlcNAc-P-P-Und synthase activity" EXACT [EC:2.7.8.33]
synonym: "UDP-GIcNAc:undecaprenyl phosphate N-acetylglucosaminyl 1-P transferase activity" EXACT [EC:2.7.8.33]
synonym: "UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase activity" EXACT [EC:2.7.8.33]
synonym: "UDP-N-acetyl-D-glucosamine:ditrans,octacis-undecaprenyl phosphate N-acetyl-D-glucosaminephosphotransferase activity" EXACT [EC:2.7.8.33]
synonym: "UDP-N-acetylglucosamine:undecaprenyl-phosphate GlcNAc-1-phosphate transferase activity" EXACT [EC:2.7.8.33]
xref: EC:2.7.8.33
xref: KEGG:R08856
xref: MetaCyc:GLCNACPTRANS-RXN
xref: RHEA:28093
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups
created_by: rfoulger
creation_date: 2013-05-23T10:51:26Z

[Term]
id: GO:0036381
name: pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H2O + phosphate. The reaction occurs in two steps: L-glutamine + H2O = L-glutamate + NH3, and subsequently D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH3 = pyridoxal 5'-phosphate + 4 H2O + phosphate." [EC:4.3.3.6, GOC:rs]
synonym: "PdxST activity" EXACT [EC:4.3.3.6]
synonym: "pyridoxal 5'-phosphate synthase (glutamine hydrolyzing) activity" EXACT [EC:4.3.3.6]
xref: EC:4.3.3.6
xref: KEGG:R10089
xref: MetaCyc:RXN-11322
xref: RHEA:31510
is_a: GO:0016843 ! amine-lyase activity
created_by: rfoulger
creation_date: 2013-05-23T11:15:37Z

[Term]
id: GO:0036382
name: flavin reductase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: reduced flavin + NAD+ = flavin + NADH + H+." [EC:1.5.1.36, GOC:rs]
synonym: "flavin:NADH oxidoreductase activity" EXACT [EC:1.5.1.36]
synonym: "NADH-dependent flavin reductase activity" EXACT [EC:1.5.1.36]
xref: EC:1.5.1.36
xref: KEGG:R09662
xref: MetaCyc:1.5.1.36-RXN
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
created_by: rfoulger
creation_date: 2013-05-23T11:23:09Z

[Term]
id: GO:0036383
name: 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2 = 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H2O." [EC:1.14.14.12, GOC:rs]
xref: EC:1.14.14.12
xref: KEGG:R09819
xref: MetaCyc:1.14.14.12-RXN
xref: RHEA:31734
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
created_by: rfoulger
creation_date: 2013-05-23T11:31:09Z

[Term]
id: GO:0036384
name: cytidine diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: CDP + H2O = CMP + phosphate." [GOC:al]
synonym: "CDPase activity" EXACT [GOC:al]
is_a: GO:0017110 ! nucleoside-diphosphatase activity
created_by: rfoulger
creation_date: 2013-05-23T13:33:01Z

[Term]
id: GO:0036385
name: nucleoid DNA packaging
namespace: biological_process
def: "Any process in which DNA and associated proteins are formed into a compact, orderly structure within a nucleoid." [GOC:bf, GOC:bhm]
is_a: GO:0006323 ! DNA packaging
intersection_of: GO:0006323 ! DNA packaging
intersection_of: occurs_in GO:0009295 ! nucleoid
relationship: occurs_in GO:0009295 ! nucleoid
created_by: rfoulger
creation_date: 2013-05-30T10:36:05Z

[Term]
id: GO:0036386
name: bacterial nucleoid DNA packaging
namespace: biological_process
def: "Compaction of DNA in a bacterial nucleoid into a compact structure. Often achieved by DNA supercoiling." [GOC:bf, GOC:bhm, PMID:17097674, PMID:17360520]
synonym: "chromosomal compaction" BROAD [PMID:17097674]
synonym: "nucleoid compaction" BROAD [PMID:17097674]
synonym: "prokaryotic DNA condensation" BROAD [Wikipedia:DNA_condensation]
is_a: GO:0036385 ! nucleoid DNA packaging
intersection_of: GO:0006323 ! DNA packaging
intersection_of: occurs_in GO:0043590 ! bacterial nucleoid
relationship: occurs_in GO:0043590 ! bacterial nucleoid
created_by: rfoulger
creation_date: 2013-05-30T10:41:08Z

[Term]
id: GO:0036387
name: pre-replicative complex
namespace: cellular_component
def: "A protein-DNA complex that forms at the origin of replication during the initial step of DNA replication and allows the origin to become competent, or 'licensed', for replication." [GOC:bf, GOC:bhm, GOC:jh2, Wikipedia:Pre-replication_complex]
comment: This term describes pre-replicative complexes across organisms.
synonym: "pre-RC" EXACT [Wikipedia:Pre-replication_complex]
synonym: "pre-replication complex" EXACT [Wikipedia:Pre-replication_complex]
is_a: GO:0032993 ! protein-DNA complex
created_by: rfoulger
creation_date: 2013-06-05T16:14:52Z

[Term]
id: GO:0036388
name: pre-replicative complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the pre-replicative complex, a protein-DNA complex that forms at the origin of replication during the initial step of DNA replication and allows the origin to become competent, or 'licensed', for replication." [GOC:bf, GOC:bhm, GOC:jh2]
synonym: "pre-RC assembly" EXACT [Wikipedia:Pre-replication_complex]
synonym: "pre-replication complex assembly" RELATED [Wikipedia:Pre-replication_complex]
is_a: GO:0065004 ! protein-DNA complex assembly
relationship: part_of GO:0006261 ! DNA-dependent DNA replication
created_by: rfoulger
creation_date: 2013-06-05T16:29:13Z

[Term]
id: GO:0036389
name: bacterial pre-replicative complex
namespace: cellular_component
def: "A protein-DNA complex that forms at the bacterial oriC during the initial step of DNA replication and allows the origin to become competent, or 'licensed', for replication." [GOC:bf, GOC:bhm, GOC:jh2, PMID:19833870, PMID:21035377, Wikipedia:Pre-replication_complex]
synonym: "bacterial pre-RC" EXACT [GOC:bf, GOC:bhm, GOC:jh2]
is_a: GO:0036387 ! pre-replicative complex
relationship: has_part GO:1990101 ! DnaA-oriC complex
created_by: rfoulger
creation_date: 2013-06-05T16:41:47Z

[Term]
id: GO:0036390
name: pre-replicative complex assembly involved in bacterial-type DNA replication
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the bacterial pre-replicative complex, a protein-DNA complex that forms at the bacterial oriC during the initial step of DNA replication and allows the origin to become competent, or 'licensed', for replication." [GOC:bf, GOC:bhm, GOC:jh2, PMID:19833870, PMID:21035377, PMID:21895796]
synonym: "bacterial pre-RC assembly" EXACT [GOC:bf, GOC:bhm, GOC:jh2]
synonym: "bacterial pre-replicative complex assembly" EXACT []
is_a: GO:1902299 ! pre-replicative complex assembly involved in cell cycle DNA replication
relationship: part_of GO:0044787 ! bacterial-type DNA replication
created_by: rfoulger
creation_date: 2013-06-05T16:45:21Z

[Term]
id: GO:0036391
name: medial cortex septin ring
namespace: cellular_component
def: "A ring-shaped structure that forms at the medial cortex of a symmetrically dividing cell at the onset of cytokinesis; composed of members of the conserved family of filament forming proteins called septins as well as septin-associated proteins." [GOC:vw, PMID:16009555]
is_a: GO:0005940 ! septin ring
is_a: GO:0032161 ! cleavage apparatus septin structure
intersection_of: GO:0005940 ! septin ring
intersection_of: part_of GO:0031097 ! medial cortex
relationship: part_of GO:0031097 ! medial cortex
created_by: rfoulger
creation_date: 2013-06-06T16:12:06Z

[Term]
id: GO:0036392
name: chemokine (C-C motif) ligand 20 production
namespace: biological_process
def: "The appearance of chemokine (C-C motif) ligand 20 (CCL20) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:jc]
synonym: "C-C motif chemokine 20 production" EXACT []
synonym: "CCL-20 production" EXACT []
synonym: "CCL20 production" EXACT []
is_a: GO:0032602 ! chemokine production
created_by: rfoulger
creation_date: 2013-06-17T14:42:07Z

[Term]
id: GO:0036393
name: thiocyanate peroxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: thiocyanate (SCN-) + hydrogen peroxide (H2O2) = hypothiocyanite (OSCN-) + 2 H2O. Catalyzes the hydrogen peroxide oxidation of thiocyanate." [GOC:pm, PMID:12626341]
synonym: "lactoperoxidase activity" BROAD [PMID:12626341, Wikipedia:Lactoperoxidase]
is_a: GO:0004601 ! peroxidase activity
relationship: part_of GO:0018969 ! thiocyanate metabolic process
created_by: rfoulger
creation_date: 2013-06-20T16:03:57Z

[Term]
id: GO:0036394
name: amylase secretion
namespace: biological_process
def: "The controlled release of amylase from a cell." [GOC:jc, PMID:19028687]
synonym: "amylase release" EXACT [PMID:19028687]
is_a: GO:0009306 ! protein secretion
created_by: rfoulger
creation_date: 2013-07-01T13:03:19Z

[Term]
id: GO:0036395
name: pancreatic amylase secretion
namespace: biological_process
def: "The controlled release of amylase from a cell of the pancreas." [GOC:jc, PMID:19028687]
is_a: GO:0036394 ! amylase secretion
relationship: part_of GO:0030157 ! pancreatic juice secretion
created_by: rfoulger
creation_date: 2013-07-01T13:42:34Z

[Term]
id: GO:0036396
name: MIS complex
namespace: cellular_component
def: "An mRNA methyltransferase complex that catalyzes the post-transcriptional methylation of adenosine to form N6-methyladenosine (m6A). In budding yeast, the MIS complex consists of Mum2p, Ime4p and Slz1p. In vertebrates, the complex consists of METTL3, METTL14 and WTAP." [GOC:dgf, GOC:sp, PMID:22685417, PMID:24316715]
synonym: "Mum2, Ime4, and Slz1 complex" EXACT [PMID:22685417]
synonym: "WMM complex" EXACT []
is_a: GO:0034708 ! methyltransferase complex
is_a: GO:0045293 ! mRNA editing complex
created_by: rfoulger
creation_date: 2013-07-15T10:17:50Z

[Term]
id: GO:0036397
name: formate dehydrogenase (quinone) activity
namespace: molecular_function
def: "Catalysis of the reaction: formate + a quinone = CO2 + a quinol." [EC:1.1.5.6, GOC:bm]
synonym: "Fdh-N activity" RELATED [EC:1.1.5.6]
synonym: "formate dehydrogenase-N activity" RELATED [EC:1.1.5.6]
synonym: "formate:quinone oxidoreductase activity" EXACT [EC:1.1.5.6]
xref: EC:1.1.5.6
xref: KEGG:R09494
xref: MetaCyc:FORMATEDEHYDROG-RXN
is_a: GO:0052738 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, with a quinone or similar compound as acceptor
created_by: rfoulger
creation_date: 2013-07-18T13:11:41Z

[Term]
id: GO:0036398
name: TCR signalosome
namespace: cellular_component
def: "A multi-protein complex containing at least the T-cell receptor complex and the LAT (linker for activation of T cells) scaffold protein. Also contains a variety of signaling proteins including co-receptors, kinases, phosphatases and adaptors such as CD8. Connects events on the plasma membrane to distal signaling cascades to ultimately modulate T cell biology." [GOC:krc, PMID:17534068, PMID:20107804, PMID:22426112]
synonym: "LAT signalosome" EXACT [GOC:krc, PMID:17534068]
synonym: "linker for activation of T cells signalosome" EXACT [PMID:17534068]
is_a: GO:0043234 ! protein complex
relationship: has_part GO:0042101 ! T cell receptor complex
created_by: rfoulger
creation_date: 2013-07-18T13:52:24Z

[Term]
id: GO:0036399
name: TCR signalosome assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a TCR signalosome." [GOC:krc, PMID:22426112]
synonym: "LAT signalosome assembly" EXACT [GOC:krc, PMID:17534068]
synonym: "linker for activation of T cells signalosome assembly" EXACT [PMID:17534068]
is_a: GO:0006461 ! protein complex assembly
created_by: rfoulger
creation_date: 2013-07-18T14:02:53Z

[Term]
id: GO:0036400
name: short neuropeptide F receptor activity
namespace: molecular_function
def: "Combining with a short neuropeptide F and transmitting the signal within the cell to initiate a change in cell activity. Short neuropeptide F is an arthropod peptide of less than 28 residues (as small as 8-10 residues in some species) with a C-terminal RFamide or LRFamide." [GOC:ha, PMID:16330127, PMID:21440021]
comment: Despite their naming, neuropeptide F (NPF) and short neuropeptide F (sNPF) are not closely related.
synonym: "sNPF receptor activity" EXACT [PMID:12372405, PMID:21440021]
is_a: GO:0008188 ! neuropeptide receptor activity
created_by: rfoulger
creation_date: 2013-07-18T14:46:40Z

[Term]
id: GO:0036401
name: pyrokinin receptor activity
namespace: molecular_function
def: "Combining with a pyrokinin and transmitting the signal within the cell to induce a change in cell activity. Pyrokinins are a group of insect neuropeptides that share the common C-terminal pentapeptide sequence Phe-X-Pro-Arg-Leu-NH2 (X = S, T, K, A, or G). They play a central role in diverse physiological processes including stimulation of gut motility, production and release of sex pheromones, diapause, and pupariation." [GOC:ha, PMID:12951076, PMID:19186060]
synonym: "PK receptor activity" EXACT [PMID:17065249]
is_a: GO:0008188 ! neuropeptide receptor activity
created_by: rfoulger
creation_date: 2013-07-18T15:10:55Z

[Term]
id: GO:0036402
name: proteasome-activating ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, which promotes unfolding of protein substrates, and channel opening of the core proteasome." [GOC:rb, PMID:11430818]
synonym: "ATPase involved in positive regulation of proteasomal protein catabolic process" EXACT [GOC:bf]
synonym: "proteasomal ATPase activity" EXACT [GOC:bf]
synonym: "proteasome channel gating activity" NARROW [GOC:rb]
synonym: "proteasome channel opening activity" NARROW [GOC:rb]
is_a: GO:0042623 ! ATPase activity, coupled
intersection_of: GO:0016887 ! ATPase activity
intersection_of: part_of GO:1901800 ! positive regulation of proteasomal protein catabolic process
relationship: part_of GO:1901800 ! positive regulation of proteasomal protein catabolic process
created_by: rfoulger
creation_date: 2013-08-12T11:38:20Z

[Term]
id: GO:0036403
name: arachidonate 8(S)-lipoxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: arachidonate + O(2) = (5Z,8S,9E,11Z,14Z)-8-hydroperoxyicosa-5,9,11,14-tetraenoate." [EC:1.13.11.-, GOC:lb, PMID:10625675]
comment: This activity produces the S-enantiomer of HPETE, 8(S)-HPETE. For the reaction producing the S-enantiomer, see GO:0047677.
synonym: "8(S)-lipoxygenase activity" BROAD [GOC:bf]
synonym: "8-lipoxygenase (S-type)" BROAD [KEGG:R07053]
xref: EC:1.13.11.-
xref: KEGG:R07053
xref: RHEA:38678
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
created_by: rfoulger
creation_date: 2013-08-14T11:48:46Z

[Term]
id: GO:0036404
name: conversion of ds siRNA to ss siRNA
namespace: biological_process
def: "The process in which double-stranded small interfering RNA (ds siRNA) molecules are converted to single-stranded small interfering RNA (ss siRNA)." [GOC:vw]
synonym: "conversion of double-stranded small interfering RNA to single-stranded small interfering RNA." RELATED [GOC:bf]
is_a: GO:0006396 ! RNA processing
relationship: part_of GO:0031050 ! dsRNA fragmentation
created_by: rfoulger
creation_date: 2013-08-14T14:24:19Z

[Term]
id: GO:0036405
name: anchored component of cell outer membrane
namespace: cellular_component
def: "The component of the cell outer membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:md]
synonym: "anchored to cell outer membrane" NARROW []
is_a: GO:0031225 ! anchored component of membrane
is_a: GO:0031230 ! intrinsic component of cell outer membrane
intersection_of: GO:0031225 ! anchored component of membrane
intersection_of: part_of GO:0009279 ! cell outer membrane
relationship: part_of GO:0009279 ! cell outer membrane
created_by: rfoulger
creation_date: 2013-08-15T11:40:41Z

[Term]
id: GO:0036406
name: anchored component of periplasmic side of cell outer membrane
namespace: cellular_component
def: "The component of the cell outer membrane consisting of gene products and protein complexes that are tethered to the periplasmic side of membrane by only a covalently attached anchor, embedded in the periplasmic side of the membrane only." [GOC:dos, GOC:md]
synonym: "anchored to internal side of cell outer membrane" EXACT []
synonym: "anchored to periplasmic side of cell outer membrane" NARROW []
is_a: GO:0031246 ! intrinsic component of periplasmic side of cell outer membrane
is_a: GO:0036405 ! anchored component of cell outer membrane
intersection_of: GO:0036405 ! anchored component of cell outer membrane
intersection_of: part_of GO:0031241 ! periplasmic side of cell outer membrane
relationship: part_of GO:0031241 ! periplasmic side of cell outer membrane
created_by: rfoulger
creation_date: 2013-08-15T11:45:39Z

[Term]
id: GO:0036407
name: mycolate outer membrane
namespace: cellular_component
def: "A mycolic acid-rich cell outer membrane containing a lipid bilayer and long-chain mycolic acids (hydroxylated branched-chain fatty acids) that are covalently linked to the cell wall peptidoglycan via an arabinogalactan network. Found in mycobacteria and related genera (e.g. corynebacteria)." [GOC:bf, GOC:das, GOC:md, PMID:18316738, PMID:18567661]
synonym: "MOM" EXACT [GOC:md]
synonym: "mycobacterial outer membrane" EXACT [GOC:md]
synonym: "mycolate outer membrane" NARROW [GOC:md]
synonym: "mycomembrane" EXACT [GOC:das, GOC:md]
is_a: GO:0009279 ! cell outer membrane
created_by: rfoulger
creation_date: 2013-08-15T13:33:46Z

[Term]
id: GO:0036408
name: histone acetyltransferase activity (H3-K14 specific)
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 14) = CoA + histone H3 N6-acetyl-L-lysine (position 14)." [GOC:vw, PMID:21289066]
synonym: "histone lysine N-acetyltransferase activity (H3-K14 specific)" EXACT [GOC:bf]
is_a: GO:0010484 ! H3 histone acetyltransferase activity
relationship: part_of GO:0044154 ! histone H3-K14 acetylation
created_by: rfoulger
creation_date: 2013-08-21T10:03:10Z

[Term]
id: GO:0036409
name: histone H3-K14 acetyltransferase complex
namespace: cellular_component
def: "A protein complex that can catalyze the acetylation of lysine at position 14 in histone H3." [GOC:vw, PMID:21289066]
synonym: "H3-K14 histone acetyltransferase complex" EXACT [GOC:bf]
synonym: "histone acetyltransferase complex (H3-K14 specific)" EXACT [GOC:bf]
synonym: "histone H3 Lys 14 (H3K14) acetyltransferase complex" EXACT [PMID:21289066]
synonym: "histone H3K14 acetyltransferase complex" EXACT [PMID:21289066]
is_a: GO:0070775 ! H3 histone acetyltransferase complex
created_by: rfoulger
creation_date: 2013-08-21T10:06:34Z

[Term]
id: GO:0036410
name: Mst2 histone acetyltransferase complex
namespace: cellular_component
def: "A protein complex that can catalyze the acetylation of lysine at position 14 in histone H3, and contains Mst2 as the catalytic subunit. In fission yeast, contains at least Mst2, Nto1, Ptf2, Ptf1 and Eaf6." [GOC:vw, PMID:21289066]
synonym: "Mst2 complex" EXACT [PMID:21289066]
synonym: "Mst2 H3K14 acetyltransferase complex" EXACT [PMID:21289066]
synonym: "Mst2 histone H3K14 acetyltransferase complex" EXACT [PMID:21289066]
is_a: GO:0036409 ! histone H3-K14 acetyltransferase complex
created_by: rfoulger
creation_date: 2013-08-21T10:11:32Z

[Term]
id: GO:0036411
name: H-NS-Cnu complex
namespace: cellular_component
def: "A trimeric protein complex containing a H-NS homodimer and a Cnu monomer. In bacteria, this complex negatively regulates transcription of a range of genes." [GOC:bhm, PMID:18189420, PMID:22358512]
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part
relationship: has_part GO:1990121 ! H-NS complex
created_by: rfoulger
creation_date: 2013-08-22T10:19:24Z

[Term]
id: GO:0036412
name: acetyl-CoA:oxalate CoA-transferase
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + oxalate = acetate + oxalyl-CoA." [GOC:imk, PMID:23935849]
xref: RHEA:37883
is_a: GO:0008410 ! CoA-transferase activity
created_by: rfoulger
creation_date: 2013-08-22T13:43:25Z

[Term]
id: GO:0036413
name: histone H3-R26 citrullination
namespace: biological_process
def: "The hydrolysis of peptidyl-arginine to form peptidyl-citrulline at position 26 in histone H3." [GOC:als, PMID:22853951]
synonym: "histone H3 arginine 26 citrullination" EXACT [GOC:als]
is_a: GO:0036414 ! histone citrullination
created_by: rfoulger
creation_date: 2013-08-22T13:59:15Z

[Term]
id: GO:0036414
name: histone citrullination
namespace: biological_process
def: "The hydrolysis of peptidyl-arginine to form peptidyl-citrulline on a histone protein." [GOC:als, PMID:22853951, PMID:23175390]
synonym: "histone deimination" EXACT [Wikipedia:Citrullination]
is_a: GO:0016570 ! histone modification
is_a: GO:0018101 ! protein citrullination
created_by: rfoulger
creation_date: 2013-08-22T14:04:26Z

[Term]
id: GO:0036415
name: regulation of tRNA stability
namespace: biological_process
def: "Any process that modulates the propensity of transfer RNA (tRNA) molecules to degradation. Includes processes that both stabilize and destabilize tRNAs." [GOC:aa, PMID:21502523, PMID:23572593]
is_a: GO:0043487 ! regulation of RNA stability
created_by: rfoulger
creation_date: 2013-08-22T15:22:13Z

[Term]
id: GO:0036416
name: tRNA stabilization
namespace: biological_process
def: "Prevention of degradation of tRNA molecules." [GOC:aa, GOC:bf, PMID:20459084]
is_a: GO:0036415 ! regulation of tRNA stability
is_a: GO:0043489 ! RNA stabilization
created_by: rfoulger
creation_date: 2013-08-22T15:41:26Z

[Term]
id: GO:0036417
name: tRNA destabilization
namespace: biological_process
def: "Any process that decreases the stability of a tRNA molecule, making it more vulnerable to degradative processes." [GOC:aa, GOC:bf]
is_a: GO:0036415 ! regulation of tRNA stability
is_a: GO:0050779 ! RNA destabilization
created_by: rfoulger
creation_date: 2013-08-22T15:43:13Z

[Term]
id: GO:0036418
name: intrinsic component of mycolate outer membrane
namespace: cellular_component
def: "The component of the mycolate outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:md]
synonym: "intrinsic to MOM" EXACT [GOC:md]
synonym: "intrinsic to mycolate outer membrane" NARROW []
synonym: "intrinsic to mycomembrane" EXACT [GOC:das, GOC:md]
is_a: GO:0031230 ! intrinsic component of cell outer membrane
intersection_of: GO:0031224 ! intrinsic component of membrane
intersection_of: part_of GO:0036407 ! mycolate outer membrane
relationship: part_of GO:0036407 ! mycolate outer membrane
created_by: rfoulger
creation_date: 2013-09-05T20:19:04Z

[Term]
id: GO:0036419
name: integral component of mycolate outer membrane
namespace: cellular_component
def: "The component of the mycolate outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:md]
synonym: "integral to MOM" EXACT [GOC:md]
synonym: "integral to mycolate outer membrane" NARROW []
synonym: "integral to mycomembrane" EXACT [GOC:das, GOC:md]
is_a: GO:0036418 ! intrinsic component of mycolate outer membrane
is_a: GO:0045203 ! integral component of cell outer membrane
intersection_of: GO:0016021 ! integral component of membrane
intersection_of: part_of GO:0036407 ! mycolate outer membrane
relationship: part_of GO:0036407 ! mycolate outer membrane
created_by: rfoulger
creation_date: 2013-09-05T20:20:04Z

[Term]
id: GO:0036420
name: extrinsic component of mycolate outer membrane
namespace: cellular_component
def: "The component of mycolate outer membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:md]
synonym: "extrinsic to MOM" EXACT [GOC:md]
synonym: "extrinsic to mycolate outer membrane" NARROW []
synonym: "extrinsic to mycomembrane" EXACT [GOC:das, GOC:md]
is_a: GO:0031244 ! extrinsic component of cell outer membrane
intersection_of: GO:0019898 ! extrinsic component of membrane
intersection_of: part_of GO:0036407 ! mycolate outer membrane
relationship: part_of GO:0036407 ! mycolate outer membrane
created_by: rfoulger
creation_date: 2013-09-05T20:22:02Z

[Term]
id: GO:0036421
name: extrinsic component of external side of mycolate outer membrane
namespace: cellular_component
def: "The component of mycolate membrane consisting of gene products and protein complexes that are loosely bound to its external surface, but not integrated into the hydrophobic region." [GOC:md]
synonym: "extrinsic to external side of MOM" EXACT [GOC:md]
synonym: "extrinsic to external side of mycolate outer membrane" NARROW []
synonym: "extrinsic to external side of mycomembrane" EXACT [GOC:das, GOC:md]
is_a: GO:0031242 ! extrinsic component of external side of cell outer membrane
is_a: GO:0036420 ! extrinsic component of mycolate outer membrane
intersection_of: GO:0019898 ! extrinsic component of membrane
intersection_of: part_of GO:0098568 ! external side of mycolate outer membrane
relationship: part_of GO:0098568 ! external side of mycolate outer membrane
created_by: rfoulger
creation_date: 2013-09-05T20:23:45Z

[Term]
id: GO:0036422
name: heptaprenyl diphosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate = 4 diphosphate + all-trans-heptaprenyl diphosphate." [EC:2.5.1.30, RHEA:27797]
subset: gosubset_prok
synonym: "all-trans-heptaprenyl-diphosphate synthase activity" EXACT [EC:2.5.1.30]
synonym: "HepPP synthase activity" EXACT [EC:2.5.1.30]
synonym: "heptaprenyl pyrophosphate synthase activity" EXACT [EC:2.5.1.30]
synonym: "heptaprenyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.30]
xref: EC:2.5.1.30
xref: MetaCyc:TRANS-HEXAPRENYLTRANSTRANSFERASE-RXN
xref: RHEA:27797
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups
created_by: rfoulger
creation_date: 2013-09-16T11:50:41Z

[Term]
id: GO:0036423
name: hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) activity
namespace: molecular_function
def: "Catalysis of the reaction: (2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate = 3 diphosphate + all-trans-hexaprenyl diphosphate." [EC:2.5.1.83, RHEA:27562]
synonym: "hexaprenyl diphosphate synthase activity" BROAD [EC:2.5.1.83]
synonym: "hexaprenyl pyrophosphate synthetase activity" BROAD [EC:2.5.1.83]
xref: EC:2.5.1.83
xref: KEGG:R09245
xref: MetaCyc:TRANS-PENTAPRENYLTRANSFERASE-RXN
xref: RHEA:27562 "(2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate = 3 diphosphate + all-trans-hexaprenyl diphosphate"
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups
created_by: rfoulger
creation_date: 2013-09-16T12:22:10Z

[Term]
id: GO:0036424
name: L-phosphoserine phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: O-phospho-L-serine + H2O <=> L-serine + phosphate." [RHEA:21211]
xref: KEGG:R00582
xref: MetaCyc:RXN0-5114
xref: RHEA:21211
is_a: GO:0004647 ! phosphoserine phosphatase activity
created_by: rfoulger
creation_date: 2013-09-16T13:01:03Z

[Term]
id: GO:0036425
name: D-phosphoserine phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: O-phospho-D-serine + H2O <=> L-serine + phosphate." [RHEA:24876]
xref: KEGG:R02853
xref: RHEA:24876
is_a: GO:0004647 ! phosphoserine phosphatase activity
created_by: rfoulger
creation_date: 2013-09-16T13:02:43Z

[Term]
id: GO:0036426
name: ditrans, polycis-undecaprenyl-phosphate mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ditrans,octacis-undecaprenyl phosphate + GDP-alpha-D-mannose = D-mannosyl undecaprenyl phosphate+ GDP." [RHEA:28121]
xref: KEGG:R07257
xref: MetaCyc:2.4.1.54-RXN
xref: RHEA:28121
is_a: GO:0047267 ! undecaprenyl-phosphate mannosyltransferase activity
created_by: rfoulger
creation_date: 2013-09-16T13:21:01Z

[Term]
id: GO:0036427
name: all-trans-undecaprenyl-phosphate mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: all-trans-undecaprenyl phosphate + GDP-alpha-D-mannose = D-mannosyl undecaprenyl phosphate + GDP." [RHEA:12784]
xref: RHEA:12784
is_a: GO:0047267 ! undecaprenyl-phosphate mannosyltransferase activity
created_by: rfoulger
creation_date: 2013-09-16T13:23:06Z

[Term]
id: GO:0036428
name: adenosylcobinamide kinase (GTP-specific) activity
namespace: molecular_function
def: "Catalysis of the reaction: adenosylcobinamide + GTP = adenosylcobinamide phosphate + GDP + H+." [RHEA:15768]
xref: KEGG:R06558
xref: MetaCyc:RXN-14063
xref: RHEA:15768
is_a: GO:0043752 ! adenosylcobinamide kinase activity
created_by: rfoulger
creation_date: 2013-09-16T14:05:39Z

[Term]
id: GO:0036429
name: adenosylcobinamide kinase (ATP-specific) activity
namespace: molecular_function
def: "Catalysis of the reaction: adenosylcobinamide + ATP = adenosylcobinamide phosphate + ADP + H+." [RHEA:15772]
xref: KEGG:R05221
xref: MetaCyc:COBINAMIDEKIN-RXN
xref: RHEA:15772
is_a: GO:0043752 ! adenosylcobinamide kinase activity
created_by: rfoulger
creation_date: 2013-09-16T14:05:56Z

[Term]
id: GO:0036430
name: CMP kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + CMP = ADP + CDP." [RHEA:11603]
xref: KEGG:R00512
xref: MetaCyc:RXN-11832
xref: RHEA:11603
is_a: GO:0004127 ! cytidylate kinase activity
created_by: rfoulger
creation_date: 2013-09-16T14:11:48Z

[Term]
id: GO:0036431
name: dCMP kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + dCMP = ADP + dCDP." [RHEA:25097]
synonym: "ATP:dCMP phosphotransferase activity" EXACT [KEGG:R01665]
xref: KEGG:R01665
xref: MetaCyc:RXN-11831
xref: MetaCyc:RXN-7913
xref: RHEA:25097
is_a: GO:0004127 ! cytidylate kinase activity
created_by: rfoulger
creation_date: 2013-09-16T14:11:56Z

[Term]
id: GO:0036432
name: all-trans undecaprenol kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + undecaprenol + all-trans-undecaprenyl phosphate + ADP + H+." [RHEA:23755]
xref: RHEA:23755
is_a: GO:0009038 ! undecaprenol kinase activity
created_by: rfoulger
creation_date: 2013-09-16T14:21:04Z

[Term]
id: GO:0036433
name: di-trans, poly-cis-undecaprenol kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: di-trans, octa-cis-undecaprenol + ATP = di-trans,octa-cis-undecaprenyl phosphate + ADP + H+." [RHEA:28125]
synonym: "ditrans,polycis-undecaprenol kinase activity" RELATED [CHEBI:61216]
xref: KEGG:R05626
xref: MetaCyc:UNDECAPRENOL-KINASE-RXN
xref: RHEA:28125
is_a: GO:0009038 ! undecaprenol kinase activity
created_by: rfoulger
creation_date: 2013-09-16T14:21:12Z

[Term]
id: GO:0036434
name: nitronate monooxygenase (FMN-linked) activity
namespace: molecular_function
def: "Catalysis of the reaction: ethylnitronate + FMNH(2) + O(2) = acetaldehyde + FMN + H(2)O + H(+) + nitrite." [RHEA:26461]
xref: KEGG:R00025
xref: RHEA:26461
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)
created_by: rfoulger
creation_date: 2013-09-16T16:20:13Z

[Term]
id: GO:0036435
name: K48-linked polyubiquitin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently and non-covalently with a polymer of ubiquitin formed by linkages between lysine residues at position 48 of the ubiquitin monomers." [GOC:al, PMID:20739285]
is_a: GO:0031593 ! polyubiquitin binding
created_by: rfoulger
creation_date: 2013-09-18T14:51:06Z

[Term]
id: GO:0036436
name: Isw1a complex
namespace: cellular_component
def: "An Isw1 complex that binds DNA and has nucleosome-stimulated ATPase activity. In S. cerevisiae, contains an Isw1p ATPase subunit in complex with Ioc3p." [GOC:jd, PMID:12482963]
is_a: GO:0016587 ! Isw1 complex
created_by: rfoulger
creation_date: 2013-09-18T16:45:41Z

[Term]
id: GO:0036437
name: Isw1b complex
namespace: cellular_component
def: "An Isw1 complex that binds DNA and has nucleosome-stimulated ATPase activity. In S. cerevisiae, contains an Isw1p ATPase subunit in complex with Ioc2p and Ioc4p." [GOC:jd, PMID:12482963]
is_a: GO:0016587 ! Isw1 complex
created_by: rfoulger
creation_date: 2013-09-18T16:53:07Z

[Term]
id: GO:0036438
name: maintenance of lens transparency
namespace: biological_process
def: "A homeostatic process in which the lens is maintained in a highly refractive, transparent state to allow for optimal focusing of light on the retina." [GOC:nhn, PMID:22095752]
synonym: "maintenance of ocular lens transparency" EXACT [PMID:22095752]
synonym: "preservation of lens transparency" EXACT [PMID:22095752]
is_a: GO:0001894 ! tissue homeostasis
created_by: rfoulger
creation_date: 2013-09-23T13:51:09Z

[Term]
id: GO:0036439
name: glycerol-3-phosphate dehydrogenase [NADP+] activity
namespace: molecular_function
def: "Catalysis of the reaction: glycerol 3-phosphate + NADP+ = glycerone phosphate + H+ + NADPH." [RHEA:11099]
xref: EC:1.1.1.94
xref: KEGG:R00844
xref: RHEA:11099
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
created_by: rfoulger
creation_date: 2013-09-30T10:37:46Z

[Term]
id: GO:0036440
name: citrate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA." [RHEA:16848]
xref: KEGG:R00351
xref: RHEA:16848
is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer
created_by: rfoulger
creation_date: 2013-09-30T16:21:50Z

[Term]
id: GO:0036441
name: 2-dehydropantolactone reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+." [RHEA:18984]
xref: KEGG:R03155
xref: RHEA:18984
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
created_by: rfoulger
creation_date: 2013-09-30T16:26:27Z

[Term]
id: GO:0036442
name: hydrogen-exporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out)." [RHEA:20855]
synonym: "proton-transporting ATPase activity" EXACT [GOC:bf]
is_a: GO:0019829 ! cation-transporting ATPase activity
created_by: rfoulger
creation_date: 2013-09-30T16:56:16Z

[Term]
id: GO:0036443
name: dermatan 6-sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + dermatan = adenosine 3',5'-bisphosphate + dermatan 6'-sulfate." [EC:2.8.2.33, GOC:bf, KEGG:R07288]
xref: KEGG:R07288
is_a: GO:0008146 ! sulfotransferase activity
created_by: rfoulger
creation_date: 2013-10-17T10:41:48Z

[Term]
id: GO:0036444
name: calcium ion transmembrane import into mitochondrion
namespace: biological_process
def: "A process in which a calcium ion (Ca2+) is transported from one side of a membrane to the other into the mitochondrion by means of some agent such as a transporter or pore." [GOC:vw]
synonym: "calcium ion import into mitochondrion" BROAD []
synonym: "mitochondrial calcium ion import" BROAD [GOC:vw]
is_a: GO:0006851 ! mitochondrial calcium ion transport
is_a: GO:0070509 ! calcium ion import
is_a: GO:0070588 ! calcium ion transmembrane transport
is_a: GO:1990542 ! mitochondrial transmembrane transport
created_by: rfoulger
creation_date: 2013-10-28T09:32:39Z

[Term]
id: GO:0036445
name: neuronal stem cell division
namespace: biological_process
def: "The self-renewing division of a neuronal stem cell." [CL:0000047, GOC:nhn]
synonym: "NSC division" EXACT [CL:0000047]
is_a: GO:0048103 ! somatic stem cell division
created_by: rfoulger
creation_date: 2013-10-30T10:03:27Z

[Term]
id: GO:0036446
name: myofibroblast differentiation
namespace: biological_process
def: "The process in which an undifferentiated cell acquires the features of a myofibroblast cell." [CL:0000186, GOC:nhn]
synonym: "myofibroblast cell differentiation" EXACT [CL:0000186]
is_a: GO:0030154 ! cell differentiation
created_by: rfoulger
creation_date: 2013-10-30T10:06:51Z

[Term]
id: GO:0036447
name: cellular response to sugar-phosphate stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the accumulation of sugar-phosphate." [GOC:am, PMID:17383224]
synonym: "cellular response to presence of non-metabolizable sugars" RELATED [GOC:am]
is_a: GO:0033554 ! cellular response to stress
created_by: rfoulger
creation_date: 2013-10-31T11:18:09Z

[Term]
id: GO:0036448
name: cellular response to glucose-phosphate stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the accumulation of glucose-phosphate." [GOC:am, PMID:17383224]
is_a: GO:0036447 ! cellular response to sugar-phosphate stress
created_by: rfoulger
creation_date: 2013-10-31T11:20:08Z

[Term]
id: GO:0036449
name: microtubule minus-end
namespace: cellular_component
def: "The end of a microtubule that does not preferentially grow (polymerize)." [GOC:lb, PMID:23169647]
synonym: "microtubule minus end" EXACT [GOC:lb]
is_a: GO:1990752 ! microtubule end
relationship: part_of GO:0005874 ! microtubule
created_by: rfoulger
creation_date: 2013-10-31T13:26:51Z

[Term]
id: GO:0036450
name: polyuridylation-dependent decapping of nuclear-transcribed mRNA
namespace: biological_process
def: "Cleavage of the 5'-cap of a nuclear-transcribed mRNA that has been modified by the enzymatic addition of a sequence of uridylyl residues (polyuridylation) at the 3' end." [GOC:vw, PMID:19430462]
synonym: "uridylation-dependent decapping of nuclear-transcribed mRNA" BROAD [GOC:vw]
is_a: GO:0031087 ! deadenylation-independent decapping of nuclear-transcribed mRNA
relationship: part_of GO:1990074 ! polyuridylation-dependent mRNA catabolic process
created_by: rfoulger
creation_date: 2013-11-04T11:37:28Z

[Term]
id: GO:0036451
name: cap mRNA methylation
namespace: biological_process
def: "Methylation of the 2'-O-ribose of the first or second transcribed nucleotide of a 5'-capped mRNA." [GOC:bf, PMID:20713356]
is_a: GO:0080009 ! mRNA methylation
created_by: rfoulger
creation_date: 2013-11-06T14:36:00Z

[Term]
id: GO:0036452
name: ESCRT complex
namespace: cellular_component
def: "An endosomal sorting complex required for transport." [PMID:16689637, VZ:1536]
synonym: "endosomal sorting complex required for transport" EXACT [PMID:22718754]
xref: Wikipedia:ESCRT
is_a: GO:0043234 ! protein complex
is_a: GO:0044440 ! endosomal part
created_by: rfoulger
creation_date: 2013-11-06T16:25:52Z

[Term]
id: GO:0036453
name: transitive RNA interference
namespace: biological_process
def: "An RNA interference where the silencing signal spreads along the target mRNA in a 5' or 3' direction, outside of the initial target sequence." [GOC:pf, PMID:11719187, PMID:12554873, PMID:23724097, PMID:24369430]
synonym: "transitive RNAi" EXACT [PMID:12554873]
is_a: GO:0016246 ! RNA interference
created_by: rfoulger
creation_date: 2013-11-07T11:14:03Z

[Term]
id: GO:0036454
name: growth factor complex
namespace: cellular_component
def: "A protein complex that has growth factor activity." [GOC:bm]
is_a: GO:0043234 ! protein complex
created_by: rfoulger
creation_date: 2013-11-07T11:27:16Z

[Term]
id: GO:0036455
name: iron-sulfur transferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a iron-sulfur cluster from one compound (donor) to another (acceptor)." [GOC:bhm]
synonym: "Fe-S transferase activity" EXACT [GOC:bf]
is_a: GO:0016782 ! transferase activity, transferring sulfur-containing groups
created_by: rfoulger
creation_date: 2013-11-14T11:17:37Z

[Term]
id: GO:0036456
name: L-methionine-(S)-S-oxide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-methionine (S)-S-oxide + thioredoxin -> L-methionine + thioredoxin disulfide + H2O." [GOC:vw, RHEA:19995]
xref: RHEA:19995
is_a: GO:0033744 ! L-methionine:thioredoxin-disulfide S-oxidoreductase activity
created_by: rfoulger
creation_date: 2013-11-27T11:07:19Z

[Term]
id: GO:0036457
name: keratohyalin granule
namespace: cellular_component
def: "A cytoplasmic, non-membrane bound granule of, at least, keratinocyte. Associated to keratin intermediate filaments and partially crosslinked to the cell envelope." [GOC:krc, PMID:15854042]
is_a: GO:0044444 ! cytoplasmic part
created_by: rfoulger
creation_date: 2013-12-09T13:04:09Z

[Term]
id: GO:0036458
name: hepatocyte growth factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a hepatocyte growth factor." [PR:000008534]
synonym: "HGF binding" EXACT [PR:000008534]
is_a: GO:0019838 ! growth factor binding
created_by: rfoulger
creation_date: 2013-12-09T14:07:20Z

[Term]
id: GO:0036459
name: thiol-dependent ubiquitinyl hydrolase activity
namespace: molecular_function
def: "Catalysis of the thiol-dependent hydrolysis of an ester, thioester, amide, peptide or isopeptide bond formed by the C-terminal glycine of ubiquitin." [EC:3.4.19.12, GOC:bf, GOC:ka]
comment: 20160208: Renamed to thiol-dependent ubiquitinyl hydrolase activity
synonym: "ubiquitin C-terminal hydrolase" EXACT [EC:3.4.19.12]
synonym: "ubiquitinyl hydrolase 1 activity" EXACT [EC:3.4.19.12]
synonym: "ubiquitinyl hydrolase activity" BROAD []
xref: EC:3.4.19.12
is_a: GO:0019783 ! ubiquitin-like protein-specific protease activity
is_a: GO:0101005 ! ubiquitinyl hydrolase activity
created_by: rfoulger
creation_date: 2013-12-19T09:39:38Z

[Term]
id: GO:0036460
name: cellular response to cell envelope stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stress acting at the cell envelope." [GOC:imk, PMID:15101969, PMID:15882407]
synonym: "envelope stress response" EXACT [PMID:15882407]
is_a: GO:0033554 ! cellular response to stress
created_by: rfoulger
creation_date: 2014-01-08T15:15:50Z

[Term]
id: GO:0036461
name: BLOC-2 complex binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a BLOC-2 complex, a protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules." [GOC:bf, GOC:PARL, PMID:22511774]
is_a: GO:0032403 ! protein complex binding
created_by: rebeccafoulger
creation_date: 2014-06-11T09:14:55Z

[Term]
id: GO:0036462
name: TRAIL-activated apoptotic signaling pathway
namespace: biological_process
def: "An extrinsic apoptotic signaling pathway initiated by the binding of the ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) to a death receptor on the cell surface." [GOC:bf, GOC:PARL, PMID:21785459]
synonym: "TRAIL-activated extrinsic apoptotic signaling pathway" EXACT [GOC:bf]
synonym: "TRAIL-induced apoptotic signaling pathway" EXACT [PMID:21785459]
synonym: "tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway" EXACT [PMID:21785459]
is_a: GO:0008625 ! extrinsic apoptotic signaling pathway via death domain receptors
created_by: rebeccafoulger
creation_date: 2014-06-11T09:18:41Z

[Term]
id: GO:0036463
name: TRAIL receptor activity
namespace: molecular_function
def: "Combining with the ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) and transmitting the signal from one side of the plasma membrane to the other to initiate apoptotic cell death." [GOC:bf, GOC:PARL]
synonym: "tumor necrosis factor-related apoptosis-inducing ligand receptor" EXACT [PMID:21785459]
is_a: GO:0005035 ! death receptor activity
relationship: has_part GO:0045569 ! TRAIL binding
relationship: part_of GO:0036462 ! TRAIL-activated apoptotic signaling pathway
created_by: rebeccafoulger
creation_date: 2014-06-11T09:20:30Z

[Term]
id: GO:0036464
name: cytoplasmic ribonucleoprotein granule
namespace: cellular_component
def: "A ribonucleoprotein granule located in the cytoplasm." [GOC:bf, GOC:PARL, PMID:15121898]
synonym: "Staufen granule" NARROW [PMID:15121898]
is_a: GO:0035770 ! ribonucleoprotein granule
is_a: GO:0044444 ! cytoplasmic part
intersection_of: GO:0035770 ! ribonucleoprotein granule
intersection_of: part_of GO:0005737 ! cytoplasm
relationship: part_of GO:0005737 ! cytoplasm
created_by: rebeccafoulger
creation_date: 2014-06-18T09:44:44Z

[Term]
id: GO:0036465
name: synaptic vesicle recycling
namespace: biological_process
def: "The trafficking of synaptic vesicles from the pre-synaptic membrane so the vesicle can dock and prime for another round of exocytosis and neurotransmitter release. Recycling occurs after synaptic vesicle exocytosis, and is necessary to replenish presynaptic vesicle pools, sustain transmitter release and preserve the structural integrity of the presynaptic membrane." [GOC:bf, GOC:pad, GOC:PARL, PMID:15217342, PMID:22026965, PMID:23245563]
subset: goslim_synapse
synonym: "kiss-and-run synaptic vesicle recycling" NARROW [PMID:15217342]
synonym: "kiss-and-stay synaptic vesicle recycling" NARROW [PMID:152127342]
is_a: GO:0048489 ! synaptic vesicle transport
relationship: part_of GO:0099504 ! synaptic vesicle cycle
created_by: rebeccafoulger
creation_date: 2014-06-26T11:03:08Z

[Term]
id: GO:0036466
name: synaptic vesicle recycling via endosome
namespace: biological_process
def: "Synaptic vesicle recycling where vesicles endocytose via clathrin-coated pits, re-acidify, and refill with neurotransmitters after passing through an endosomal intermediate." [GOC:bf, GOC:dos, GOC:pad, GOC:PARL, PMID:15217342]
subset: goslim_synapse
synonym: "endosomal synaptic vesicle recycling" EXACT [PMID:15217342]
is_a: GO:0032456 ! endocytic recycling
is_a: GO:0036465 ! synaptic vesicle recycling
created_by: rebeccafoulger
creation_date: 2014-06-26T11:07:46Z

[Term]
id: GO:0036467
name: 5-hydroxy-L-tryptophan decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-hydroxy-L-tryptophan + H+ = CO2 + serotonin." [GOC:bf, GOC:PARL, RHEA:18536]
synonym: "5-hydroxytryptophan decarboxylase activity" BROAD [EC:4.1.1.28]
xref: RHEA:18536
is_a: GO:0004058 ! aromatic-L-amino-acid decarboxylase activity
created_by: rebeccafoulger
creation_date: 2014-07-21T09:22:24Z

[Term]
id: GO:0036468
name: L-dopa decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-dopa + H+ = CO2 + dopamine." [GOC:bf, GOC:PARL, RHEA:12275]
synonym: "4-dihydroxyl-L-phenylalanine decarboxylase activity" EXACT [PMID:19703902]
synonym: "DDC activity" EXACT [PMID:19703902]
synonym: "DOPA decarboxylase activity" EXACT [EC:4.1.1.28]
xref: RHEA:12275
is_a: GO:0004058 ! aromatic-L-amino-acid decarboxylase activity
created_by: rebeccafoulger
creation_date: 2014-07-21T09:22:24Z

[Term]
id: GO:0036469
name: L-tryptophan decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tryptophan + H+ = CO2 + tryptamine." [GOC:bf, GOC:PARL, RHEA:30342]
synonym: "tryptophan decarboxylase activity" BROAD [EC:4.1.1.28]
xref: RHEA:30342
is_a: GO:0004058 ! aromatic-L-amino-acid decarboxylase activity
created_by: rebeccafoulger
creation_date: 2014-07-21T09:22:24Z

[Term]
id: GO:0036470
name: tyrosine 3-monooxygenase activator activity
namespace: molecular_function
def: "Interacts with and increases tyrosine 3-monooxygenase (tyrosine hydroxylase) activity." [GOC:bf, GOC:PARL, PMID:19703902]
synonym: "TH activator activity" EXACT [PMID:19703902]
synonym: "tyrosine hydroxylase activator activity" EXACT [PMID:19703902]
is_a: GO:0008047 ! enzyme activator activity
relationship: part_of GO:1903178 ! positive regulation of tyrosine 3-monooxygenase activity
relationship: positively_regulates GO:0004511 ! tyrosine 3-monooxygenase activity
created_by: rebeccafoulger
creation_date: 2014-07-21T11:06:49Z

[Term]
id: GO:0036471
name: cellular response to glyoxal
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glyoxal stimulus." [GOC:bf, GOC:PARL]
is_a: GO:0071310 ! cellular response to organic substance
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: rebeccafoulger
creation_date: 2014-07-21T11:14:33Z

[Term]
id: GO:0036472
name: suppression by virus of host protein binding
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of interaction between host proteins." [GOC:bf, GOC:PARL, PMID:17297443]
synonym: "suppression by virus of host protein interaction" EXACT [GOC:bf]
is_a: GO:0032091 ! negative regulation of protein binding
is_a: GO:0039507 ! suppression by virus of host molecular function
created_by: rebeccafoulger
creation_date: 2014-07-21T11:18:51Z

[Term]
id: GO:0036473
name: cell death in response to oxidative stress
namespace: biological_process
def: "Any biological process that results in permanent cessation of all vital functions of a cell upon exposure to an oxidative stress stimulus." [GOC:bf, GOC:PARL]
comment: This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide) show that cell death has occurred in response to an oxidative stress stimulus, but fail to provide details on death modality (accidental versus programmed). When information is provided on the cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death', GO:0006915 'apoptotic process' or GO:0097468 'programmed cell death in response to reactive oxygen species'). Also, if experimental data suggest that a gene product influences cell death indirectly, rather than being involved in the death process directly, consider annotating to a 'regulation' term.
is_a: GO:0008219 ! cell death
relationship: part_of GO:0034599 ! cellular response to oxidative stress
created_by: rebeccafoulger
creation_date: 2014-07-21T11:37:03Z

[Term]
id: GO:0036474
name: cell death in response to hydrogen peroxide
namespace: biological_process
def: "Any biological process that results in permanent cessation of all vital functions of a cell upon exposure to hydrogen peroxide (H2O2)." [GOC:bf, GOC:PARL]
comment: This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide) show that cell death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0010421 'hydrogen peroxide-mediated programmed cell death'). Also, if experimental data suggest that a gene product influences cell death indirectly, rather than being involved in the death process directly, consider annotating to a 'regulation' term.
synonym: "cell death in response to H2O2" EXACT [GOC:bf]
synonym: "hydrogen peroxide-mediated cell death" RELATED [GOC:bf]
is_a: GO:0036473 ! cell death in response to oxidative stress
relationship: part_of GO:0070301 ! cellular response to hydrogen peroxide
created_by: rebeccafoulger
creation_date: 2014-07-21T11:42:28Z

[Term]
id: GO:0036475
name: neuron death in response to oxidative stress
namespace: biological_process
def: "Any biological process that results in permanent cessation of all vital functions of a neuron upon exposure to an oxidative stress stimulus." [GOC:bf, GOC:PARL]
comment: This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide or use of neuron-specific markers) show that neuron death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the neuron death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death', GO:0006915 'apoptotic process' or GO:0010421 'hydrogen peroxide-mediated programmed cell death'), and the cell type captured as an annotation extension; or the term GO:0051402 'neuron apoptotic process' may be considered, if appropriate.
synonym: "neuronal cell death in response to oxidative stress" EXACT [GOC:bf]
synonym: "oxidative stress-induced neuron death" EXACT [GOC:bf]
is_a: GO:0036473 ! cell death in response to oxidative stress
is_a: GO:0070997 ! neuron death
created_by: rebeccafoulger
creation_date: 2014-07-21T11:44:40Z

[Term]
id: GO:0036476
name: neuron death in response to hydrogen peroxide
namespace: biological_process
def: "Any biological process that results in permanent cessation of all vital functions of a neuron upon exposure to hydrogen peroxide (H2O2)." [GOC:bf, GOC:PARL]
comment: This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide or use of neuron-specific markers) show that neuron death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the neuron death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death', GO:0006915 'apoptotic process' or GO:0010421 'hydrogen peroxide-mediated programmed cell death'), and the cell type captured as an annotation extension; or the term GO:0051402 'neuron apoptotic process' may be considered, if appropriate.
synonym: "hydrogen peroxide-induced neuron death" EXACT [GOC:bf]
synonym: "neuron death in response to H2O2" EXACT [GOC:bf]
synonym: "neuronal cell death in response to hydrogen peroxide" EXACT [GOC:bf]
is_a: GO:0036474 ! cell death in response to hydrogen peroxide
is_a: GO:0036475 ! neuron death in response to oxidative stress
created_by: rebeccafoulger
creation_date: 2014-07-21T11:46:31Z

[Term]
id: GO:0036477
name: somatodendritic compartment
namespace: cellular_component
def: "The region of a neuron that includes the cell body (cell soma) and the dendrite, but excludes the axon." [GOC:pad, GOC:PARL]
is_a: GO:0097458 ! neuron part
created_by: rebeccafoulger
creation_date: 2014-07-24T10:06:19Z

[Term]
id: GO:0036478
name: L-dopa decarboxylase activator activity
namespace: molecular_function
def: "Interacts with and increases L-dopa decarboxylase activity." [GOC:bf, GOC:PARL]
comment: GO:0036478 is reserved for cases when the activator directly interacts with L-dopa decarboxylase. When activation of L-dopa decarboxylase activity is achieved without enzyme binding, or when the mechanism of regulation is unknown, instead annotate to 'positive regulation of L-dopa decarboxylase activity ; GO:1903200'.
synonym: "DDC activator activity" EXACT [GOC:bf]
is_a: GO:0008047 ! enzyme activator activity
relationship: part_of GO:1903200 ! positive regulation of L-dopa decarboxylase activity
relationship: positively_regulates GO:0036468 ! L-dopa decarboxylase activity
created_by: rebeccafoulger
creation_date: 2014-07-24T10:10:51Z

[Term]
id: GO:0036479
name: peroxidase inhibitor activity
namespace: molecular_function
def: "Interacts with, and stops, prevents or reduces the activity of a peroxidase." [GOC:bf, GOC:PARL]
comment: GO:0036479 is reserved for cases when the inhibitor directly interacts with the peroxidase. When inhibition of peroxidase activity is achieved without enzyme binding, or when the mechanism of regulation is unknown, instead annotate to 'negative regulation of peroxidase activity ; GO:2000469'.
is_a: GO:0004857 ! enzyme inhibitor activity
relationship: negatively_regulates GO:0004601 ! peroxidase activity
relationship: part_of GO:2000469 ! negative regulation of peroxidase activity
created_by: rebeccafoulger
creation_date: 2014-07-24T10:14:45Z

[Term]
id: GO:0036480
name: neuron intrinsic apoptotic signaling pathway in response to oxidative stress
namespace: biological_process
def: "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a neuron. The pathway is induced in response to oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, and ends when the execution phase of apoptosis is triggered." [GOC:bf, GOC:PARL, PMID:23858059]
synonym: "neuron apoptosis in response to oxidative stress" RELATED [GOC:bf]
synonym: "oxidative stress-induced neuron apoptosis" BROAD [GOC:bf]
synonym: "oxidative stress-induced neuronal apoptosis" BROAD [GOC:bf]
is_a: GO:0008631 ! intrinsic apoptotic signaling pathway in response to oxidative stress
relationship: part_of GO:0036475 ! neuron death in response to oxidative stress
relationship: part_of GO:0051402 ! neuron apoptotic process
created_by: rebeccafoulger
creation_date: 2014-08-14T13:13:44Z

[Term]
id: GO:0036481
name: intrinsic apoptotic signaling pathway in response to hydrogen peroxide
namespace: biological_process
def: "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to hydrogen peroxide (H2O2)." [GOC:bf, GOC:PARL]
synonym: "H2O2-induced intrinsic apoptotic signaling pathway" RELATED [GOC:bf]
synonym: "hydrogen peroxide-induced apoptosis" BROAD [GOC:bf]
synonym: "hydrogen peroxide-induced intrinsic apoptotic signaling pathway" EXACT [GOC:bf]
synonym: "intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:bf]
is_a: GO:0008631 ! intrinsic apoptotic signaling pathway in response to oxidative stress
relationship: part_of GO:0010421 ! hydrogen peroxide-mediated programmed cell death
created_by: rebeccafoulger
creation_date: 2014-08-14T13:19:21Z

[Term]
id: GO:0036482
name: neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide
namespace: biological_process
def: "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a neuron in response to hydrogen peroxide." [GOC:bf, GOC:PARL]
synonym: "H2O2-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:bf]
synonym: "hydrogen peroxide-induced neuron apoptosis" BROAD [GOC:bf]
synonym: "hydrogen peroxide-induced neuronal apoptosis" BROAD [GOC:bf]
synonym: "neuron apoptosis in response to hydrogen peroxide" RELATED [GOC:bf]
synonym: "neuron intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:bf]
is_a: GO:0036480 ! neuron intrinsic apoptotic signaling pathway in response to oxidative stress
is_a: GO:0036481 ! intrinsic apoptotic signaling pathway in response to hydrogen peroxide
relationship: part_of GO:0036476 ! neuron death in response to hydrogen peroxide
created_by: rebeccafoulger
creation_date: 2014-08-14T13:23:32Z

[Term]
id: GO:0036483
name: neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
namespace: biological_process
def: "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a neuron. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:bf, GOC:PARL, PMID:21113145]
synonym: "endoplasmic reticulum stress-induced neuron apoptosis" BROAD [GOC:bf]
synonym: "endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:bf]
synonym: "ER stress-induced neuron apoptosis" BROAD [GOC:bf]
synonym: "ER stress-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:bf]
is_a: GO:0070059 ! intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
relationship: part_of GO:0051402 ! neuron apoptotic process
created_by: rebeccafoulger
creation_date: 2014-08-14T13:33:23Z

[Term]
id: GO:0036484
name: trunk neural crest cell migration
namespace: biological_process
def: "The characteristic movement of trunk neural crest cells from the neural tube to other locations in the vertebrate embryo." [CL:0000011, GOC:bf, GOC:mat, GOC:PARL, PMID:2387238]
synonym: "trunk NCC migration" EXACT [PMID:2387238]
is_a: GO:0001755 ! neural crest cell migration
relationship: part_of GO:0035290 ! trunk segmentation
created_by: rebeccafoulger
creation_date: 2014-08-26T15:27:44Z

[Term]
id: GO:0036485
name: dorsolateral trunk neural crest cell migration
namespace: biological_process
def: "The movement of trunk neural crest cells from the neural tube, travelling dorso-laterally into the ectoderm and continuing toward the ventral midline of the belly. These migrating trunk neural crest cells become melanocytes, the melanin-forming pigment cells." [GOC:bf, GOC:mat, GOC:PARL, PMID:2387238]
synonym: "dorsolateral trunk NCC migration" EXACT [PMID:2387238]
is_a: GO:0036484 ! trunk neural crest cell migration
created_by: rebeccafoulger
creation_date: 2014-08-26T15:29:04Z

[Term]
id: GO:0036486
name: ventral trunk neural crest cell migration
namespace: biological_process
def: "The movement of trunk neural crest cells from the neural tube, travelling ventrally through the anterior half of each sclerotome. Trunk neural crest cells that remain in the sclerotome form the dorsal root ganglia containing the sensory neurons. Trunk neural crest cells that continue more ventrally form the sympathetic ganglia, the adrenal medulla, and the nerve clusters surrounding the aorta." [GOC:bf, GOC:mat, GOC:PARL, PMID:16319111, PMID:19386662]
synonym: "trunk NCC migration through anterior sclerotome" EXACT [PMID:19386662]
synonym: "trunk NCC migration within somite" EXACT [GOC:mat]
synonym: "ventral trunk NCC migration" EXACT [GOC:bf]
is_a: GO:0036484 ! trunk neural crest cell migration
created_by: rebeccafoulger
creation_date: 2014-08-26T15:30:16Z

[Term]
id: GO:0036487
name: nitric-oxide synthase inhibitor activity
namespace: molecular_function
def: "Interacts with, and stops, prevents or reduces the activity of nitric oxide synthase." [GOC:BHF, GOC:rl, PMID:17242280]
synonym: "nitric oxide synthase inhibitor activity" EXACT [GOC:bf]
synonym: "NOS inhibitor activity" EXACT [GOC:bf]
is_a: GO:0004857 ! enzyme inhibitor activity
is_a: GO:0030235 ! nitric-oxide synthase regulator activity
relationship: negatively_regulates GO:0004517 ! nitric-oxide synthase activity
created_by: rebeccafoulger
creation_date: 2014-09-09T15:07:20Z

[Term]
id: GO:0036488
name: CHOP-C/EBP complex
namespace: cellular_component
def: "A heterodimeric protein complex that is composed of the transcription factor CHOP (GADD153) and a member of the C/EBP family of transcription factors." [GOC:bf, GOC:PARL, PMID:1547942]
synonym: "CHOP-C/EBP dimer" EXACT [PMID:8657121]
synonym: "CHOP-C/EBP heterodimer" EXACT [PMID:8657121]
synonym: "GADD153-C/EBP complex" EXACT [PMID:8657121]
synonym: "GADD153-C/EBP-alpha complex" NARROW [PMID:8657121]
is_a: GO:0090575 ! RNA polymerase II transcription factor complex
created_by: rebeccafoulger
creation_date: 2014-11-06T13:18:49Z

[Term]
id: GO:0036489
name: neuromelanin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of neuromelanin. Neuromelanin is a polymer of 5,6-dihydroxyindole monomers." [GOC:bf, GOC:PARL, Wiki:Neuromelanin]
synonym: "neuromelanin anabolism" EXACT [GOC:bf]
synonym: "neuromelanin biosynthesis" EXACT [GOC:bf]
synonym: "neuromelanin formation" EXACT [GOC:bf]
synonym: "neuromelanin synthesis" EXACT [GOC:bf]
is_a: GO:0009059 ! macromolecule biosynthetic process
created_by: rebeccafoulger
creation_date: 2014-11-06T13:21:46Z

[Term]
id: GO:0036490
name: regulation of translation in response to endoplasmic reticulum stress
namespace: biological_process
def: "Modulation of the frequency, rate or extent of translation as a result of endoplasmic reticulum stress." [GOC:bf, GOC:PARL, PMID:14676213, PMID:16835242]
synonym: "regulation of translation in response to ER stress" EXACT [GOC:bf]
is_a: GO:0034976 ! response to endoplasmic reticulum stress
is_a: GO:0043555 ! regulation of translation in response to stress
created_by: rebeccafoulger
creation_date: 2015-02-05T09:50:11Z

[Term]
id: GO:0036491
name: regulation of translation initiation in response to endoplasmic reticulum stress
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of translation initiation, as a result of endoplasmic reticulum stress." [GOC:bf, GOC:PARL, PMID:14676213, PMID:16835242]
synonym: "regulation of translation initiation in response to ER stress" EXACT [GOC:bf]
is_a: GO:0036490 ! regulation of translation in response to endoplasmic reticulum stress
is_a: GO:0043558 ! regulation of translational initiation in response to stress
created_by: rebeccafoulger
creation_date: 2015-02-05T09:52:13Z

[Term]
id: GO:0036492
name: eiF2alpha phosphorylation in response to endoplasmic reticulum stress
namespace: biological_process
def: "The addition of a phosphate group on to the translation initiation factor eIF2alpha, as a result of endoplasmic reticulum stress." [GOC:bf, GOC:PARL, PMID:14676213, PMID:16835242]
synonym: "eiF2alpha phosphorylation in response to ER stress" EXACT [GOC:bf]
synonym: "regulation of translation initiation by eiF2alpha phosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:bf]
is_a: GO:0010998 ! regulation of translational initiation by eIF2 alpha phosphorylation
is_a: GO:0036491 ! regulation of translation initiation in response to endoplasmic reticulum stress
created_by: rebeccafoulger
creation_date: 2015-02-05T09:53:21Z

[Term]
id: GO:0036493
name: positive regulation of translation in response to endoplasmic reticulum stress
namespace: biological_process
def: "Any process that activates, or increases the frequency, rate or extent of translation as a result of endoplasmic reticulum stress." [GOC:bf, GOC:PARL]
synonym: "positive regulation of translation in response to ER stress" EXACT [GOC:bf]
is_a: GO:0032056 ! positive regulation of translation in response to stress
is_a: GO:0036490 ! regulation of translation in response to endoplasmic reticulum stress
created_by: rebeccafoulger
creation_date: 2015-02-05T10:09:51Z

[Term]
id: GO:0036494
name: positive regulation of translation initiation in response to endoplasmic reticulum stress
namespace: biological_process
def: "Any process that activates, or increases the frequency, rate or extent of translation initiation as a result of endoplasmic reticulum stress." [GOC:bf, GOC:PARL]
synonym: "positive regulation of translation initiation in response to ER stress" EXACT [GOC:bf]
is_a: GO:0032058 ! positive regulation of translational initiation in response to stress
is_a: GO:0036491 ! regulation of translation initiation in response to endoplasmic reticulum stress
is_a: GO:0036493 ! positive regulation of translation in response to endoplasmic reticulum stress
created_by: rebeccafoulger
creation_date: 2015-02-05T10:11:32Z

[Term]
id: GO:0036495
name: negative regulation of translation initiation in response to endoplasmic reticulum stress
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of translation initiation as a result of endoplasmic reticulum stress." [GOC:bf, GOC:PARL]
synonym: "negative regulation of translation initiation in response to ER stress" RELATED [GOC:bf]
is_a: GO:0032057 ! negative regulation of translational initiation in response to stress
is_a: GO:0036491 ! regulation of translation initiation in response to endoplasmic reticulum stress
is_a: GO:1902010 ! negative regulation of translation in response to endoplasmic reticulum stress
created_by: rebeccafoulger
creation_date: 2015-02-05T10:13:38Z

[Term]
id: GO:0036496
name: regulation of translational initiation by eIF2 alpha dephosphorylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of translation initiation in response to stress by the dephosphorylation of eIF2 alpha." [GOC:bf, GOC:PARL]
is_a: GO:0006470 ! protein dephosphorylation
is_a: GO:0043558 ! regulation of translational initiation in response to stress
is_a: GO:0044710 ! single-organism metabolic process
is_a: GO:0044763 ! single-organism cellular process
created_by: rebeccafoulger
creation_date: 2015-02-05T10:21:31Z

[Term]
id: GO:0036497
name: eIF2alpha dephosphorylation in response to endoplasmic reticulum stress
namespace: biological_process
def: "The removal of a phosphate group from the translation initiation factor eIF2alpha, as a result of endoplasmic reticulum stress." [GOC:bf, GOC:PARL, PMID:16835242]
synonym: "eIF2alpha dephosphorylation in response to ER stress" EXACT [GOC:bf]
synonym: "regulation of translation initiation by eIF2alpha dephosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:bf]
is_a: GO:0036491 ! regulation of translation initiation in response to endoplasmic reticulum stress
is_a: GO:0036496 ! regulation of translational initiation by eIF2 alpha dephosphorylation
created_by: rebeccafoulger
creation_date: 2015-02-05T10:24:18Z

[Term]
id: GO:0036498
name: IRE1-mediated unfolded protein response
namespace: biological_process
def: "A series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). Begins with activation of IRE1 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 in mammals; IRE1 cleaves an intron of a mRNA coding for HAC1/XBP1 to generate an activated HAC1/XBP1 transcription factor, which controls the up regulation of UPR-related genes. At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB." [GOC:bf, GOC:PARL, PMID:22013210]
comment: Consider also annotating to 'eiF2alpha phosphorylation in response to endoplasmic reticulum stress ; GO:0036492' or its descendants.
synonym: "endoplasmic reticulum unfolded protein response; IRE1 signaling" EXACT [GOC:bf]
synonym: "ERN1-mediated unfolded protein response" RELATED [HGNC:3449]
synonym: "inositol-requiring enzyme 1-mediated unfolded protein response" RELATED [HGNC:3449]
synonym: "inositol-requiring transmembrane kinase/endonuclease signal transduction" RELATED [PMID:22013210]
synonym: "IRE1 branch of UPR" EXACT [GOC:bf]
synonym: "IRE1 signal transduction pathway" BROAD [GOC:bf]
synonym: "IRE1 signaling in response to endoplasmic reticulum stress" RELATED [GOC:bf]
synonym: "IRE1alpha unfolded protein response" NARROW [PMID:22013210]
synonym: "IRE1p unfolded protein response" NARROW [PMID:22013210]
synonym: "UPR signaling by IRE1 stress sensor" EXACT [GOC:bf]
is_a: GO:0030968 ! endoplasmic reticulum unfolded protein response
created_by: rebeccafoulger
creation_date: 2015-02-05T13:12:12Z

[Term]
id: GO:0036499
name: PERK-mediated unfolded protein response
namespace: biological_process
def: "A series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor PERK (PKR-like ER kinase). Begins with activation of PERK in response to endoplasmic reticulum (ER) stress and ends with regulation of a downstream cellular process, e.g. transcription. The main substrate of PERK is the translation initiation factor eIF2alpha. Serine-phosphorylation of eIF2alpha by PERK inactivates eIF2alpha and inhibits general protein translation. In addition, eIF2alpha phosphorylation preferentially increases the translation of selective mRNAs such as ATF4 (activating transcription factor 4), which up regulates a subset of UPR genes required to restore folding capacity." [GOC:bf, GOC:PARL, PMID:22013210]
synonym: "EIF2AK3-mediated unfolded protein response" RELATED [HGNC:3255]
synonym: "endoplasmic reticulum unfolded protein response; PERK signaling" EXACT [GOC:bf]
synonym: "eukaryotic translation initiation factor 2-alpha kinase 3-mediated unfolded protein response" RELATED [HGNC:3255]
synonym: "PERK branch of UPR" EXACT [GOC:bf]
synonym: "PERK signal transduction pathway" BROAD [GOC:bf]
synonym: "PERK signaling in response to endoplasmic reticulum stress" RELATED [GOC:bf]
synonym: "PKR-like ER kinase signal transduction" EXACT [PMID:22013210]
synonym: "UPR signaling by PERK stress sensor" EXACT [GOC:bf]
is_a: GO:0006984 ! ER-nucleus signaling pathway
is_a: GO:0030968 ! endoplasmic reticulum unfolded protein response
created_by: rebeccafoulger
creation_date: 2015-02-05T13:17:43Z

[Term]
id: GO:0036500
name: ATF6-mediated unfolded protein response
namespace: biological_process
def: "A series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor ATF6 (activating transcription factor 6). Begins with activation of ATF6 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. Under conditions of endoplasmic reticulum stress, ATF6 translocates to the Golgi where it is processed by proteases to release a cytoplasmic domain (ATF6f), which operates as a transcriptional activator of many genes required to restore folding capacity." [GOC:bf, GOC:PARL, PMID:22013210]
synonym: "activating transcription factor 6 signaling in unfolded protein response" EXACT [GOC:bf]
synonym: "ATF6 branch of UPR" EXACT [GOC:bf]
synonym: "ATF6 signal transduction pathway" BROAD [GOC:bf]
synonym: "ATF6 signaling in response to endoplasmic reticulum stress" RELATED [GOC:bf]
synonym: "ATF6-alpha UPR branch" NARROW [GOC:bf]
synonym: "ATF6-beta UPR branch" NARROW [GOC:bf]
synonym: "endoplasmic reticulum unfolded protein response; ATF6 signaling" EXACT [GOC:bf]
synonym: "UPR signaling by ATF6 stress sensor" EXACT [GOC:bf]
is_a: GO:0006984 ! ER-nucleus signaling pathway
is_a: GO:0030968 ! endoplasmic reticulum unfolded protein response
created_by: rebeccafoulger
creation_date: 2015-02-05T13:18:58Z

[Term]
id: GO:0036501
name: UFD1-NPL4 complex
namespace: cellular_component
def: "A dimeric protein complex that contains the co-factors for the ATPase VCP/p97 (Cdc48p in budding yeast). In mammals, this complex consists of UFD1L (UFD1) and NPLOC4 (NPL4). In budding yeast, the complex is a dimer of Ufd1p and Npl4p." [GOC:bf, GOC:PARL, PMID:10811609, PMID:17289586]
synonym: "Npl4p-Ufd1p complex" EXACT [PMID:17289586]
synonym: "Ufd1-Npl4 binary complex" EXACT [PMID:10811609]
synonym: "Ufd1-Npl4 cofactor complex" EXACT [PMID:10811609]
synonym: "Ufd1/Npl4 complex" EXACT [PMID:10811609]
synonym: "UFD1L-NPLOC4 complex" EXACT [GOC:bf]
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part
created_by: rebeccafoulger
creation_date: 2015-05-14T10:59:43Z

[Term]
id: GO:0036502
name: Derlin-1-VIMP complex
namespace: cellular_component
def: "A protein complex containing, in mammals, Derlin-1 and VCP-interacting membrane protein (VIMP). The complex links the p97/VCP-containing ATPase complex with Derlin-1 during translocation of protein substrates from the endoplasmic reticulum to the cytosol for degradation by the cytosolic proteasome." [GOC:bf, GOC:PARL, PMID:15215856, PMID:16186510]
synonym: "Derlin-1/VIMP complex" EXACT [PMID:15215856]
is_a: GO:0044432 ! endoplasmic reticulum part
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane
created_by: rebeccafoulger
creation_date: 2015-05-14T11:40:45Z

[Term]
id: GO:0036503
name: ERAD pathway
namespace: biological_process
def: "The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:bf, GOC:PARL]
synonym: "endoplasmic reticulum-associated degradation" EXACT [PMID:22535891]
synonym: "endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:bf]
synonym: "ER-associated degradation pathway" RELATED [PMID:24699081]
synonym: "protein degradation by ERAD" EXACT [GOC:bf]
is_a: GO:0010033 ! response to organic substance
is_a: GO:0030163 ! protein catabolic process
is_a: GO:0034976 ! response to endoplasmic reticulum stress
is_a: GO:0044712 ! single-organism catabolic process
is_a: GO:0044763 ! single-organism cellular process
created_by: rebeccafoulger
creation_date: 2015-05-14T11:43:06Z

[Term]
id: GO:0036504
name: Golgi membrane fusion
namespace: biological_process
def: "The joining of two lipid bilayers that surround the Golgi apparatus to form a single Golgi membrane." [GOC:bf, GOC:PARL, PMID:12473691]
synonym: "membrane fusion involved in Golgi reassembly" EXACT [GOC:bf]
synonym: "post-mitotic fusion of Golgi membranes" EXACT [PMID:10811609]
is_a: GO:0090174 ! organelle membrane fusion
relationship: part_of GO:0090168 ! Golgi reassembly
created_by: rebeccafoulger
creation_date: 2015-05-21T10:05:06Z

[Term]
id: GO:0036505
name: prosaposin receptor activity
namespace: molecular_function
def: "Combining with prosaposin to initiate a change in cell activity. Prosaposin is the glycoprotein precursor of four cleavage products (saposins A, B, C and D)." [GOC:bf, GOC:PARL, PMID:23690594, PMID:9388493, PR:000031300]
synonym: "prosaposin-activated receptor activity" EXACT [GOC:bf]
is_a: GO:0004930 ! G-protein coupled receptor activity
created_by: rebeccafoulger
creation_date: 2015-06-11T10:13:10Z

[Term]
id: GO:0036506
name: maintenance of unfolded protein
namespace: biological_process
def: "Maintaining a protein in an unfolded, soluble state." [GOC:bf, GOC:BHF, GOC:nc, GOC:PARL, PMID:21636303]
is_a: GO:0031647 ! regulation of protein stability
created_by: rebeccafoulger
creation_date: 2015-06-11T10:17:36Z

[Term]
id: GO:0036507
name: protein demannosylation
namespace: biological_process
def: "The removal of one or more mannose residues from a mannosylated protein." [GOC:bf, GOC:PARL, PMID:25092655]
comment: Consider also annotating to the term 'mannosyl-oligosaccharide 1,2-alpha-mannosidase activity ; GO:0004571'.
synonym: "protein de-mannosylation" EXACT [GOC:bf]
is_a: GO:0006517 ! protein deglycosylation
relationship: has_part GO:0015923 ! mannosidase activity
created_by: rebeccafoulger
creation_date: 2015-06-11T13:57:01Z

[Term]
id: GO:0036508
name: protein alpha-1,2-demannosylation
namespace: biological_process
def: "The removal of one or more alpha 1,2-linked mannose residues from a mannosylated protein." [GOC:bf, GOC:PARL, PMID:21062743, PMID:25092655]
comment: Consider also annotating to 'mannosyl-oligosaccharide 1,2-alpha-mannosidase activity ; GO:0004571'.
synonym: "glycoprotein mannose trimming" RELATED [GOC:bf]
synonym: "mannose trimming" BROAD [PMID:21062743]
is_a: GO:0036507 ! protein demannosylation
relationship: has_part GO:0004571 ! mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
created_by: rebeccafoulger
creation_date: 2015-06-11T13:58:50Z

[Term]
id: GO:0036509
name: trimming of terminal mannose on B branch
namespace: biological_process
def: "The removal of an alpha-1,2-linked mannose from the B-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum." [GOC:bf, GOC:PARL, KEGG:R06722, PMID:22160784]
comment: Consider also annotating to 'mannosyl-oligosaccharide 1,2-alpha-mannosidase activity ; GO:0004571'.
synonym: "conversion of (Man)9(GlcNAc)2 to (Man)8B(GlcNAc)2" RELATED [PMID:22160784]
synonym: "conversion of M9 to M8B" RELATED [PMID:25092655]
synonym: "glycoprotein mannose trimming on B branch" EXACT [GOC:bf]
xref: KEGG:R06722
is_a: GO:1904380 ! endoplasmic reticulum mannose trimming
created_by: rebeccafoulger
creation_date: 2015-06-11T14:02:44Z

[Term]
id: GO:0036510
name: trimming of terminal mannose on C branch
namespace: biological_process
def: "The removal of an alpha-1,2-linked mannose from the C-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum." [GOC:bf, GOC:PARL, PMID:20065073]
comment: Consider also annotating to 'mannosyl-oligosaccharide 1,2-alpha-mannosidase activity ; GO:0004571'.
synonym: "conversion of (Man)9(GlcNAc)2 to (Man)8C(GlcNAc)2" RELATED [PMID:20065073]
synonym: "conversion of M9 to M8C" RELATED [GOC:bf]
synonym: "glycoprotein mannose trimming on C branch" EXACT [GOC:bf]
is_a: GO:1904380 ! endoplasmic reticulum mannose trimming
created_by: rebeccafoulger
creation_date: 2015-06-11T14:10:52Z

[Term]
id: GO:0036511
name: trimming of first mannose on A branch
namespace: biological_process
def: "The removal of the first alpha-1,2-linked mannose from the A-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum." [GOC:bf, GOC:PARL, PMID:12829701]
comment: Consider also annotating to 'mannosyl-oligosaccharide 1,2-alpha-mannosidase activity ; GO:0004571'.
synonym: "conversion of (Man)9(GlcNAc)2 to (Man)8A(GlcNAc)2" RELATED [GOC:bf]
synonym: "conversion of M9 to M8A" RELATED [GOC:bf]
synonym: "glycoprotein mannose trimming on A branch" BROAD [GOC:bf]
is_a: GO:1904380 ! endoplasmic reticulum mannose trimming
created_by: rebeccafoulger
creation_date: 2015-06-11T14:14:03Z

[Term]
id: GO:0036512
name: trimming of second mannose on A branch
namespace: biological_process
def: "The removal of the second alpha-1,2-linked mannose from the A-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum." [GOC:bf, GOC:PARL, PMID:12829701]
comment: Consider also annotating to 'mannosyl-oligosaccharide 1,2-alpha-mannosidase activity ; GO:0004571'.
synonym: "conversion of (Man)8A(GlcNAc)2 to (Man)7AA(GlcNAc)2" RELATED [GOC:bf]
synonym: "conversion of M8A to M7AA" RELATED [GOC:bf]
synonym: "glycoprotein mannose trimming on A branch" BROAD [GOC:bf]
is_a: GO:1904380 ! endoplasmic reticulum mannose trimming
created_by: rebeccafoulger
creation_date: 2015-06-11T14:16:40Z

[Term]
id: GO:0036513
name: Derlin-1 retrotranslocation complex
namespace: cellular_component
def: "A protein complex that functions in the retrotranslocation step of ERAD (ER-associated protein degradation), and includes at its core Derlin-1 oligomers forming a retrotranslocation channel." [GOC:bf, GOC:PARL, PMID:15215856, PMID:16186510]
comment: The Derlin-1 retrotranslocation complex is likely to assemble in steps, thereby containing different components at different stages of the retrotranslocation process.
synonym: "Derlin-1 complex" EXACT [PMID:18555783]
synonym: "Derlin-1 protein dislocation complex" EXACT [PMID:18555783]
synonym: "Derlin-1 retro-translocation complex" EXACT [GOC:bf]
synonym: "Derlin-1 retrotranslocon" EXACT [GOC:bf]
synonym: "ERAD protein dislocation complex" EXACT [PMID:18555783]
is_a: GO:0044432 ! endoplasmic reticulum part
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane
created_by: rebeccafoulger
creation_date: 2015-07-01T10:17:30Z

[Term]
id: GO:0036514
name: dopaminergic neuron axon guidance
namespace: biological_process
def: "The chemotaxis process that directs the migration of an axon growth cone of a dopaminergic neuron to a specific target site in response to a combination of attractive and repulsive cues." [GOC:bf, GOC:PARL, PMID:21106844, PMID:23517308]
synonym: "DA axon guidance" EXACT [PMID:23517308]
synonym: "dopaminergic axon guidance" EXACT [GOC:bf]
synonym: "mdDA axon guidance" EXACT [PMID:21106844]
is_a: GO:0007411 ! axon guidance
created_by: rebeccafoulger
creation_date: 2015-12-17T11:14:20Z

[Term]
id: GO:0036515
name: serotonergic neuron axon guidance
namespace: biological_process
def: "The chemotaxis process that directs the migration of an axon growth cone of a serotonergic neuron to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000850, GOC:bf, GOC:PARL, PMID:21106844]
synonym: "5-HT axon guidance" EXACT [GOC:bf, PMID:21106844]
synonym: "serotonergic axon guidance" EXACT [GOC:bf]
is_a: GO:0007411 ! axon guidance
created_by: rebeccafoulger
creation_date: 2015-12-17T11:15:54Z

[Term]
id: GO:0036516
name: chemoattraction of dopaminergic neuron axon
namespace: biological_process
def: "The process in which a dopaminergic neuron growth cone is directed to a specific target site in response to an attractive chemical signal." [GOC:bf, GOC:PARL, PMID:21106844]
synonym: "chemoattraction of DA axon" EXACT [GOC:bf]
synonym: "chemoattraction of dopaminergic axon" EXACT [GOC:bf]
is_a: GO:0061642 ! chemoattraction of axon
intersection_of: GO:0050918 ! positive chemotaxis
intersection_of: part_of GO:0036514 ! dopaminergic neuron axon guidance
relationship: part_of GO:0036514 ! dopaminergic neuron axon guidance
created_by: rebeccafoulger
creation_date: 2015-12-17T11:23:11Z

[Term]
id: GO:0036517
name: chemoattraction of serotonergic neuron axon
namespace: biological_process
def: "The process in which a serotonergic neuron growth cone is directed to a specific target site in response to an attractive chemical signal." [CL:0000850, GOC:bf, GOC:PARL, PMID:21106844]
synonym: "chemoattraction of 5-HT axon" EXACT [GOC:bf, PMID:21106844]
synonym: "chemoattraction of serotonergic axon" EXACT [GOC:bf]
is_a: GO:0061642 ! chemoattraction of axon
intersection_of: GO:0050918 ! positive chemotaxis
intersection_of: part_of GO:0036515 ! serotonergic neuron axon guidance
relationship: part_of GO:0036515 ! serotonergic neuron axon guidance
created_by: rebeccafoulger
creation_date: 2015-12-17T11:26:03Z

[Term]
id: GO:0036518
name: chemorepulsion of dopaminergic neuron axon
namespace: biological_process
def: "The process in which a dopaminergic neuron growth cone is directed to a specific target site in response to a repulsive chemical cue." [GOC:bf, GOC:PARL, PMID:21106844, PMID:23517308]
synonym: "chemorepulsion of DA axon" EXACT [GOC:bf, PMID:23517308]
synonym: "chemorepulsion of dopaminergic axon" RELATED [GOC:bf]
is_a: GO:0061643 ! chemorepulsion of axon
intersection_of: GO:0050919 ! negative chemotaxis
intersection_of: part_of GO:0036514 ! dopaminergic neuron axon guidance
relationship: part_of GO:0036514 ! dopaminergic neuron axon guidance
created_by: rebeccafoulger
creation_date: 2015-12-17T11:29:09Z

[Term]
id: GO:0036519
name: chemorepulsion of serotonergic neuron axon
namespace: biological_process
def: "The process in which a serotonergic neuron growth cone is directed to a specific target site in response to a repulsive chemical cue." [CL:0000850, GOC:bf, GOC:PARL, PMID:21106844]
synonym: "chemorepulsion of 5-HT axon" EXACT [GOC:bf, PMID:21106844]
synonym: "chemorepulsion of serotonergic axon" RELATED [GOC:bf]
is_a: GO:0061643 ! chemorepulsion of axon
intersection_of: GO:0050919 ! negative chemotaxis
intersection_of: part_of GO:0036515 ! serotonergic neuron axon guidance
relationship: part_of GO:0036515 ! serotonergic neuron axon guidance
created_by: rebeccafoulger
creation_date: 2015-12-17T11:31:16Z

[Term]
id: GO:0036520
name: astrocyte-dopaminergic neuron signaling
namespace: biological_process
def: "Cell-cell signaling that mediates the transfer of information from an astrocyte to a dopaminergic neuron." [GOC:bf, GOC:PARL, PMID:12794311, PMID:21752258]
synonym: "astrocyte-dopaminergic neuron cell signaling" EXACT [GOC:bf]
synonym: "dopaminergic neuron-astrocyte crosstalk" RELATED [PMID:21752258]
synonym: "mesencephalic dopaminergic neuron-astrocyte crosstalk" NARROW [PMID:21752258]
synonym: "midbrain dopaminergic neuron-astrocyte crosstalk" NARROW [PMID:21752258]
is_a: GO:0007267 ! cell-cell signaling
created_by: rebeccafoulger
creation_date: 2016-02-29T14:05:47Z

[Term]
id: GO:0038001
name: paracrine signaling
namespace: biological_process
def: "The transfer of information from one cell to another, where the signal travels from the signal-producing cell to the receiving cell by passive diffusion or bulk flow in intercellular fluid. The signaling cell and the receiving cell are usually in the vicinity of each other." [GOC:mtg_signaling_feb11, ISBN:3527303782]
comment: This term should be used with caution, and only used when the signaling between cells has been clearly distinguished from endocrine signaling.
synonym: "paracrine signalling" EXACT [GOC:bf]
is_a: GO:0007267 ! cell-cell signaling
created_by: rfoulger
creation_date: 2011-02-25T02:11:00Z

[Term]
id: GO:0038002
name: endocrine signaling
namespace: biological_process
def: "The transfer of information from one cell to another, where an endocrine hormone is transported from the signal-producing cell to the receiving cell via the circulatory system (via blood, lymph or cerebrospinal fluid). The signaling cell and the receiving cell are often distant to each other." [GOC:mtg_signaling_feb11, ISBN:0199264678, ISBN:3527303782]
comment: This term should be used with caution, and only used when the signaling between cells has been clearly distinguished from paracrine signaling.
synonym: "endocrine signalling" EXACT [GOC:bf]
is_a: GO:0007267 ! cell-cell signaling
relationship: part_of GO:0050886 ! endocrine process
created_by: rfoulger
creation_date: 2011-02-25T02:12:19Z

[Term]
id: GO:0038003
name: opioid receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of an opioid receptor binding to one of its physiological ligands." [GOC:bf, PMID:20494127]
synonym: "opioid receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0007186 ! G-protein coupled receptor signaling pathway
created_by: rfoulger
creation_date: 2011-03-03T02:00:02Z

[Term]
id: GO:0038004
name: epidermal growth factor receptor ligand maturation
namespace: biological_process
def: "Any process leading to the attainment of the full functional capacity of a ligand for an epidermal growth factor receptor. The ligand is functional when it can bind to and activate an epidermal growth factor receptor." [GOC:signaling, PMID:11672524]
synonym: "EGFR ligand maturation" EXACT [GOC:bf]
is_a: GO:0035638 ! signal maturation
is_a: GO:0044710 ! single-organism metabolic process
is_a: GO:0045742 ! positive regulation of epidermal growth factor receptor signaling pathway
is_a: GO:0051604 ! protein maturation
created_by: rfoulger
creation_date: 2011-06-07T03:06:41Z

[Term]
id: GO:0038005
name: peptide bond cleavage involved in epidermal growth factor receptor ligand maturation
namespace: biological_process
def: "The hydrolysis of a peptide bond or bonds within a ligand for the epidermal growth factor receptor, as part of protein maturation, the process leading to the attainment of the full functional capacity of a protein. In Drosophila for example, in the Golgi apparatus of the signal producing cell, Spitz is cleaved within its transmembrane domain to release a functional soluble extracellular fragment." [GOC:signaling, PMID:11672524, PMID:11672525]
synonym: "EGFR ligand maturation by peptide bond cleavage" EXACT [GOC:bf]
synonym: "EGFR ligand processing" EXACT [GOC:bf]
synonym: "epidermal growth factor receptor ligand processing" EXACT [GOC:bf]
synonym: "peptide bond cleavage involved in EGFR ligand maturation" EXACT [GOC:bf]
is_a: GO:0016485 ! protein processing
intersection_of: GO:0016485 ! protein processing
intersection_of: part_of GO:0038004 ! epidermal growth factor receptor ligand maturation
relationship: has_part GO:0006509 ! membrane protein ectodomain proteolysis
relationship: part_of GO:0038004 ! epidermal growth factor receptor ligand maturation
created_by: rfoulger
creation_date: 2011-06-07T03:08:41Z

[Term]
id: GO:0038006
name: netrin receptor activity involved in chemoattraction
namespace: molecular_function
def: "Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to contribute to the directed movement of a motile cell towards a higher concentration of netrin." [GOC:signaling]
synonym: "attractive netrin receptor activity" EXACT [GOC:bf]
synonym: "netrin receptor activity involved in positive chemotaxis" EXACT [GOC:bf]
is_a: GO:0005042 ! netrin receptor activity
intersection_of: GO:0005042 ! netrin receptor activity
intersection_of: part_of GO:0050918 ! positive chemotaxis
relationship: part_of GO:0050918 ! positive chemotaxis
created_by: rfoulger
creation_date: 2011-06-10T02:22:29Z

[Term]
id: GO:0038007
name: netrin-activated signaling pathway
namespace: biological_process
def: "A series of molecular events initiated by the binding of a netrin protein to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Netrins can act as chemoattractant signals for some cells and chemorepellent signals for others. Netrins also have roles outside of cell and axon guidance." [GOC:signaling, PMID:10399919, PMID:15960985, PMID:19785719, PMID:20108323]
synonym: "netrin signaling pathway" EXACT [GOC:bf]
synonym: "netrin-activated signal transduction pathway" EXACT [GOC:bf]
synonym: "netrin-activated signalling pathway" EXACT [GOC:bf]
synonym: "netrin-mediated signaling pathway" EXACT [GOC:bf]
is_a: GO:0007166 ! cell surface receptor signaling pathway
created_by: rfoulger
creation_date: 2011-06-10T02:24:59Z

[Term]
id: GO:0038008
name: TRAF-mediated signal transduction
namespace: biological_process
def: "The intracellular process in which a signal is passed on to downstream components within the cell via a tumor necrosis factor receptor-associated factor (TRAF). TRAFs are directly or indirectly recruited to the intracellular domains of cell surface receptors, and engage other signaling proteins to transfer the signal from a cell surface receptor to other intracellular signaling components." [GOC:bf, PMID:19918944, PMID:20596822]
synonym: "TRAF signaling" EXACT [GOC:bf]
synonym: "TRAF-mediated intracellular signaling" EXACT [GOC:bf]
synonym: "TRAF-mediated signaling" EXACT [GOC:bf]
synonym: "TRAF-mediated signalling" EXACT [GOC:bf]
synonym: "tumor necrosis factor receptor-associated factor signal transduction" EXACT [GOC:bf]
synonym: "tumor necrosis factor receptor-associated factor signaling" EXACT [GOC:bf]
is_a: GO:0035556 ! intracellular signal transduction
created_by: rfoulger
creation_date: 2011-06-22T04:01:54Z

[Term]
id: GO:0038009
name: regulation of signal transduction by receptor internalization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of signal transduction by the movement of a signaling receptor from the plasma membrane to the inside of the cell. Receptor internalization can have a positive or negative effect on a signaling pathway." [GOC:bf, GOC:signaling, PMID:17011816, PMID:19696798]
synonym: "regulation of signaling pathway by receptor endocytosis" EXACT [GOC:bf]
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0031623 ! receptor internalization
intersection_of: GO:0031623 ! receptor internalization
intersection_of: regulates GO:0007165 ! signal transduction
relationship: regulates GO:0007165 ! signal transduction
created_by: rfoulger
creation_date: 2011-06-23T03:28:47Z

[Term]
id: GO:0038010
name: positive regulation of signal transduction by receptor internalization
namespace: biological_process
def: "Any process in which the internalization of a signaling receptor activates or increases the frequency, rate or extent of signal transduction. Receptor internalization can enhance signaling by concentrating signaling molecules in one location, or by moving a ligand-activated receptor to the location of downstream signaling proteins. Endosomes for example can serve as important intracellular signaling platforms." [GOC:bf, GOC:signaling, PMID:17908284, PMID:19696798]
synonym: "positive regulation of signaling pathway by receptor endocytosis" EXACT [GOC:bf]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0038009 ! regulation of signal transduction by receptor internalization
intersection_of: GO:0031623 ! receptor internalization
intersection_of: positively_regulates GO:0007165 ! signal transduction
relationship: positively_regulates GO:0007165 ! signal transduction
created_by: rfoulger
creation_date: 2011-06-23T03:37:10Z

[Term]
id: GO:0038011
name: negative regulation of signal transduction by receptor internalization
namespace: biological_process
def: "Any process in which internalization of a signaling receptor stops, prevents, or reduces the frequency, rate or extent of signal transduction. Receptor internalization can attenuate or reduce the strength of signaling by reducing the concentration of cell surface receptors available to ligands." [GOC:bf, GOC:signaling, PMID:17908284, PMID:19696798]
synonym: "negative regulation of signaling pathway by receptor endocytosis" EXACT [GOC:bf]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0038009 ! regulation of signal transduction by receptor internalization
intersection_of: GO:0031623 ! receptor internalization
intersection_of: negatively_regulates GO:0007165 ! signal transduction
relationship: negatively_regulates GO:0007165 ! signal transduction
created_by: rfoulger
creation_date: 2011-06-23T03:39:06Z

[Term]
id: GO:0038012
name: negative regulation of Wnt signaling pathway by Wnt receptor internalization
namespace: biological_process
def: "Any process in which internalization of a Wnt receptor stops, prevents, or reduces the frequency, rate or extent of Wnt signal transduction." [GOC:bf, GOC:BHF, GOC:rl, PMID:17908284, PMID:19643732]
synonym: "ligand-dependent internalization of Frizzled" NARROW [PMID:19643732]
synonym: "negative regulation of Wnt receptor signaling pathway by Wnt receptor endocytosis" NARROW [GOC:bf]
synonym: "negative regulation of Wnt receptor signaling pathway by Wnt receptor internalization" EXACT []
synonym: "negative regulation of Wnt receptor signalling pathway by Wnt receptor internalization" EXACT [GOC:mah]
synonym: "negative regulation of Wnt-activated signaling pathway by Wnt receptor internalization" EXACT [GOC:signaling]
is_a: GO:0030178 ! negative regulation of Wnt signaling pathway
is_a: GO:0038011 ! negative regulation of signal transduction by receptor internalization
is_a: GO:0038017 ! Wnt receptor internalization
intersection_of: GO:0038017 ! Wnt receptor internalization
intersection_of: negatively_regulates GO:0016055 ! Wnt signaling pathway
relationship: negatively_regulates GO:0016055 ! Wnt signaling pathway
created_by: rfoulger
creation_date: 2011-06-23T03:57:59Z

[Term]
id: GO:0038013
name: positive regulation of Wnt signaling pathway by Wnt receptor internalization
namespace: biological_process
def: "Any process in which internalization of a Wnt receptor activates or increases the frequency, rate or extent of the Wnt signaling pathway." [GOC:bf, GOC:signaling, PMID:17908284]
synonym: "positive regulation of Wnt receptor signaling pathway by Frizzled internalization" RELATED []
synonym: "positive regulation of Wnt receptor signaling pathway by LRP6 internalization" NARROW [GOC:bf]
synonym: "positive regulation of Wnt receptor signaling pathway by Wnt receptor internalization" EXACT []
synonym: "positive regulation of Wnt receptor signalling pathway by Wnt receptor endocytosis" EXACT [GOC:bf]
synonym: "positive regulation of Wnt-activated signaling pathway by Wnt receptor internalization" RELATED [GOC:signaling]
is_a: GO:0030177 ! positive regulation of Wnt signaling pathway
is_a: GO:0038010 ! positive regulation of signal transduction by receptor internalization
is_a: GO:0038017 ! Wnt receptor internalization
intersection_of: GO:0038017 ! Wnt receptor internalization
intersection_of: positively_regulates GO:0016055 ! Wnt signaling pathway
relationship: positively_regulates GO:0016055 ! Wnt signaling pathway
created_by: rfoulger
creation_date: 2011-06-23T04:02:21Z

[Term]
id: GO:0038014
name: negative regulation of insulin receptor signaling pathway by insulin receptor internalization
namespace: biological_process
def: "Any process in which internalization of an insulin receptor stops, prevents, or reduces the frequency, rate or extent of insulin receptor signal transduction. Internalization of insulin in association with its receptor clears insulin from the circulation and is necessary for subsequent insulin dissociation from the receptor and insulin degradation." [GOC:bf, GOC:signaling, PMID:18492485, PMID:7821727, PMID:7978876, PMID:9609114]
synonym: "agonist-stimulated insulin receptor internalization" BROAD [PMID:18492485]
synonym: "negative regulation of insulin receptor signalling pathway by insulin receptor internalization" EXACT [GOC:mah]
is_a: GO:0038011 ! negative regulation of signal transduction by receptor internalization
is_a: GO:0038016 ! insulin receptor internalization
is_a: GO:0046627 ! negative regulation of insulin receptor signaling pathway
intersection_of: GO:0038016 ! insulin receptor internalization
intersection_of: negatively_regulates GO:0008286 ! insulin receptor signaling pathway
relationship: negatively_regulates GO:0008286 ! insulin receptor signaling pathway
created_by: rfoulger
creation_date: 2011-06-23T04:08:31Z

[Term]
id: GO:0038015
name: positive regulation of insulin receptor signaling pathway by insulin receptor internalization
namespace: biological_process
def: "Any process in which internalization of an insulin receptor activates or increases the frequency, rate or extent of the insulin receptor signaling pathway. Endocytosis of activated receptors can concentrate receptors within endosomes and allow the insulin receptor to phosphorylate substrates that are spatially distinct from those accessible at the plasma membrane." [GOC:bf, GOC:signaling, PMID:9609114]
synonym: "positive regulation of insulin receptor signalling pathway by insulin receptor internalization" EXACT [GOC:mah]
is_a: GO:0038010 ! positive regulation of signal transduction by receptor internalization
is_a: GO:0038016 ! insulin receptor internalization
is_a: GO:0046628 ! positive regulation of insulin receptor signaling pathway
intersection_of: GO:0038016 ! insulin receptor internalization
intersection_of: positively_regulates GO:0008286 ! insulin receptor signaling pathway
relationship: positively_regulates GO:0008286 ! insulin receptor signaling pathway
created_by: rfoulger
creation_date: 2011-06-23T04:20:11Z

[Term]
id: GO:0038016
name: insulin receptor internalization
namespace: biological_process
def: "A receptor-mediated endocytosis process that results in the movement of an insulin receptor from the plasma membrane to the inside of the cell." [GOC:bf, PMID:3907718, PMID:9609114]
synonym: "insulin receptor endocytosis" BROAD [GOC:bf]
is_a: GO:0031623 ! receptor internalization
created_by: rfoulger
creation_date: 2011-06-23T04:24:52Z

[Term]
id: GO:0038017
name: Wnt receptor internalization
namespace: biological_process
def: "A receptor-mediated endocytosis process that results in the movement of a Wnt receptor from the plasma membrane to the inside of the cell." [GOC:bf, PMID:17908284]
synonym: "Wnt receptor endocytosis" BROAD [GOC:bf]
is_a: GO:0031623 ! receptor internalization
created_by: rfoulger
creation_date: 2011-06-23T04:25:47Z

[Term]
id: GO:0038018
name: Wnt receptor catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a Wnt receptor. Internalized Wnt receptors can be recycled to the plasma membrane or sorted to lysosomes for protein degradation." [GOC:BHF, GOC:rl, GOC:signaling, PMID:19643732]
synonym: "Frizzled degradation" NARROW [PMID:19643732]
synonym: "negative regulation of Wnt receptor signaling pathway by Wnt receptor degradation" EXACT [GOC:bf]
synonym: "Wnt receptor breakdown" EXACT [GOC:bf]
synonym: "Wnt receptor catabolism" EXACT [GOC:bf]
synonym: "Wnt receptor degradation" RELATED [GOC:bf]
is_a: GO:0032801 ! receptor catabolic process
relationship: part_of GO:0030178 ! negative regulation of Wnt signaling pathway
created_by: rfoulger
creation_date: 2011-06-23T04:38:12Z

[Term]
id: GO:0038019
name: Wnt receptor recycling
namespace: biological_process
def: "The process that results in the return of a Wnt receptor to an active state at the plasma membrane. An active state is when the receptor is ready to receive a Wnt signal. Internalized Wnt receptors can be recycled to the plasma membrane or sorted to lysosomes for protein degradation." [GOC:bf, GOC:signaling, PMID:19643732]
synonym: "Frizzled recycling" NARROW [PMID:19643732]
is_a: GO:0001881 ! receptor recycling
relationship: part_of GO:0030177 ! positive regulation of Wnt signaling pathway
created_by: rfoulger
creation_date: 2011-06-23T04:46:11Z

[Term]
id: GO:0038020
name: insulin receptor recycling
namespace: biological_process
def: "The process that results in the return of an insulin receptor to an active state at the plasma membrane. An active state is when the receptor is ready to receive an insulin signal. Internalized insulin receptors can be recycled to the plasma membrane or sorted to lysosomes for protein degradation." [GOC:bf, GOC:signaling, PMID:3907718]
is_a: GO:0001881 ! receptor recycling
relationship: part_of GO:0046628 ! positive regulation of insulin receptor signaling pathway
created_by: rfoulger
creation_date: 2011-06-23T04:52:05Z

[Term]
id: GO:0038021
name: leptin receptor activity
namespace: molecular_function
def: "Combining with the fat-cell specific hormone leptin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, GOC:signaling, PMID:9102398, Wikipedia:Leptin_receptor]
is_a: GO:0004896 ! cytokine receptor activity
relationship: part_of GO:0033210 ! leptin-mediated signaling pathway
created_by: rfoulger
creation_date: 2011-06-27T01:36:45Z

[Term]
id: GO:0038022
name: G-protein coupled olfactory receptor activity
namespace: molecular_function
def: "Combining with an odorant and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:sart, PMID:21041441]
synonym: "G-protein coupled odorant receptor activity" EXACT [GOC:bf, PMID:21041441]
synonym: "odorant receptor activity, G-protein coupled" NARROW [GOC:bf, PMID:21041441]
synonym: "olfactory receptor activity, G-protein coupled" EXACT [GOC:bf]
is_a: GO:0004930 ! G-protein coupled receptor activity
is_a: GO:0004984 ! olfactory receptor activity
created_by: rfoulger
creation_date: 2011-07-01T11:23:51Z

[Term]
id: GO:0038023
name: signaling receptor activity
namespace: molecular_function
def: "Receiving a signal and transmitting the signal in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]
comment: Note that this term and its child terms are intended for receptors that are directly coupled to a signal transduction pathway. This term should therefore not be used to annotate decoy receptors and other proteins that bind a signal but do not pass the signal on. This term can be used to annotate dependence receptors that transduce a signal when a ligand is withdrawn (in this case, signal withdrawal is considered to be the initiating signal), or receptors that signal at a basal level in the absence of a bound agonist. For receptors that mediate transport of a substance into the cell by receptor-mediated endocytosis, consider instead the term 'cargo receptor activity ; GO:0038024' and its children.
synonym: "receptor activity involved in signal transduction" EXACT [GOC:bf]
synonym: "signalling receptor activity" EXACT [GOC:mah]
is_a: GO:0004871 ! signal transducer activity
is_a: GO:0004872 ! receptor activity
intersection_of: GO:0004872 ! receptor activity
intersection_of: part_of GO:0007165 ! signal transduction
relationship: part_of GO:0007165 ! signal transduction
created_by: rfoulger
creation_date: 2011-08-01T02:45:27Z

[Term]
id: GO:0038024
name: cargo receptor activity
namespace: molecular_function
def: "Combining selectively with an extracellular substance and delivering the substance into the cell via endocytosis." [GOC:bf, GOC:signaling, PMID:15239958]
comment: Note that this term and its child terms are intended for receptors that bind to and internalize molecules by receptor-mediated endocytosis. For receptors that are coupled to a signal transduction pathway, consider instead the term 'signaling receptor activity ; GO:0038023' and its children.
synonym: "endocytic receptor activity" RELATED [GOC:signaling, ISBN:0123645387, PMID:12671190]
synonym: "receptor activity involved in ligand uptake" EXACT [PMID:12671190]
synonym: "receptor activity involved in receptor-mediated endocytosis" EXACT [GOC:bf]
synonym: "transport receptor activity" RELATED [GOC:signaling]
is_a: GO:0004872 ! receptor activity
intersection_of: GO:0004872 ! receptor activity
intersection_of: part_of GO:0006898 ! receptor-mediated endocytosis
relationship: part_of GO:0006898 ! receptor-mediated endocytosis
created_by: rfoulger
creation_date: 2011-08-01T02:50:45Z

[Term]
id: GO:0038025
name: reelin receptor activity
namespace: molecular_function
def: "Combining with the secreted glycoprotein reelin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, PMID:12827279, PMID:20223215, PR:000013879]
synonym: "reeler receptor activity" EXACT [PR:000013879]
is_a: GO:0004888 ! transmembrane signaling receptor activity
relationship: part_of GO:0038026 ! reelin-mediated signaling pathway
created_by: rfoulger
creation_date: 2011-08-02T12:01:25Z

[Term]
id: GO:0038026
name: reelin-mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of reelin (a secreted glycoprotein) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, PMID:12827279, PMID:20223215, PR:000013879]
synonym: "reeler-mediated signaling pathway" EXACT [GOC:bf, PR:000013879]
synonym: "reelin-mediated signal transduction pathway" EXACT [GOC:bf]
synonym: "reelin-mediated signalling pathway" EXACT [GOC:bf]
is_a: GO:0007166 ! cell surface receptor signaling pathway
created_by: rfoulger
creation_date: 2011-08-02T02:06:18Z

[Term]
id: GO:0038027
name: apolipoprotein A-I-mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of apolipoprotein A-I to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:signaling, PMID:16443932]
synonym: "apolipoprotein A-I-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0007166 ! cell surface receptor signaling pathway
created_by: rfoulger
creation_date: 2011-08-02T02:13:41Z

[Term]
id: GO:0038028
name: insulin receptor signaling pathway via phosphatidylinositol 3-kinase
namespace: biological_process
def: "The series of molecular signals generated as a consequence of the insulin receptor binding to its physiological ligand, where the signal is passed on via the phosphatidylinositol 3-kinase cascade." [GOC:bf, GOC:signaling, PMID:19322168, PMID:20696212]
synonym: "insulin receptor signaling pathway via phosphatidylinositol 3-kinase cascade" RELATED []
synonym: "insulin receptor signaling pathway via PI3K cascade" EXACT [GOC:bf]
synonym: "insulin receptor signaling via PI3K" EXACT [GOC:bf]
synonym: "insulin receptor signalling pathway via phosphatidylinositol 3-kinase cascade" EXACT [GOC:mah]
is_a: GO:0008286 ! insulin receptor signaling pathway
relationship: has_part GO:0014065 ! phosphatidylinositol 3-kinase signaling
created_by: rfoulger
creation_date: 2011-09-08T10:35:14Z

[Term]
id: GO:0038029
name: epidermal growth factor receptor signaling pathway via MAPK cascade
namespace: biological_process
def: "The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to one of its physiological ligands, where the signal is passed on via the MAPKKK cascade." [GOC:bf, GOC:signaling, PMID:21167805]
synonym: "EGFR signaling pathway via MAPKKK cascade" EXACT [GOC:bf]
synonym: "EGFR signaling via MAPKKK cascade" EXACT [GOC:bf]
synonym: "EGFR/MAPK signaling" EXACT [GOC:bf]
synonym: "epidermal growth factor receptor signaling pathway via MAPKKK cascade" EXACT [GOC:signaling]
synonym: "epidermal growth factor receptor signalling pathway via MAPKKK cascade" EXACT [GOC:bf]
is_a: GO:0007173 ! epidermal growth factor receptor signaling pathway
relationship: has_part GO:0000165 ! MAPK cascade
created_by: rfoulger
creation_date: 2011-09-08T10:53:01Z

[Term]
id: GO:0038030
name: non-canonical Wnt signaling pathway via MAPK cascade
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, where the signal is passed on via the MAPKKK cascade." [GOC:BHF, GOC:signaling, GOC:vk, PMID:17720811]
synonym: "non-canonical Wnt receptor signaling pathway via MAPK cascade" EXACT []
synonym: "non-canonical Wnt receptor signaling pathway via MAPK signaling" EXACT [GOC:bf]
synonym: "non-canonical Wnt receptor signaling pathway via MAPKKK cascade" EXACT [GOC:signaling]
synonym: "non-canonical Wnt receptor signalling pathway via MAPKKK cascade" EXACT [GOC:bf]
synonym: "non-canonical Wnt-activated signaling pathway via MAPK cascade" EXACT [GOC:signaling]
is_a: GO:0035567 ! non-canonical Wnt signaling pathway
relationship: has_part GO:0000165 ! MAPK cascade
created_by: rfoulger
creation_date: 2011-09-08T01:46:07Z

[Term]
id: GO:0038031
name: non-canonical Wnt signaling pathway via JNK cascade
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, where the signal is passed on via the JNK cascade." [GOC:BHF, GPC:rl, PMID:19137009, PMID:20032469]
synonym: "non-canonical Wnt receptor signaling pathway via JNK cascade" EXACT []
synonym: "non-canonical Wnt receptor signalling pathway via JNK cascade" EXACT [GOC:bf]
synonym: "non-canonical Wnt-activated signaling pathway via JNK cascade" EXACT [GOC:signaling]
is_a: GO:0038030 ! non-canonical Wnt signaling pathway via MAPK cascade
relationship: has_part GO:0007254 ! JNK cascade
created_by: rfoulger
creation_date: 2011-09-08T01:57:10Z

[Term]
id: GO:0038032
name: termination of G-protein coupled receptor signaling pathway
namespace: biological_process
def: "The signaling process in which G-protein coupled receptor signaling is brought to an end. For example, through the action of GTPase-activating proteins (GAPs) that act to accelerate hydrolysis of GTP to GDP on G-alpha proteins, thereby terminating the transduced signal." [GOC:bf, GOC:signaling]
synonym: "termination of G-protein coupled receptor signalling pathway" EXACT [GOC:mah]
synonym: "termination of GPCR signaling pathway" EXACT [GOC:bf]
is_a: GO:0023021 ! termination of signal transduction
is_a: GO:0045744 ! negative regulation of G-protein coupled receptor protein signaling pathway
created_by: rfoulger
creation_date: 2011-09-16T10:31:21Z

[Term]
id: GO:0038033
name: positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a VEGFR on the surface of a cell, which activates or increases the frequency, rate or extent of endothelial cell chemotaxis." [GOC:bf, GOC:BHF, GOC:rl, PMID:21245381]
synonym: "positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signalling pathway" EXACT [GOC:mah]
synonym: "positive regulation of endothelial cell chemotaxis by VEGF/VEGFR signaling pathway" EXACT [GOC:bf]
synonym: "vascular endothelial growth factor receptor signaling pathway involved in endothelial cell chemotaxis" RELATED [GOC:bf]
synonym: "VEGF-mediated chemotactic endothelial cell migration" BROAD [GOC:bf, PMID:21245381]
synonym: "VEGF-VEGFR-induced endothelial cell chemotaxis" EXACT [GOC:bf]
is_a: GO:0038089 ! positive regulation of cell migration by vascular endothelial growth factor signaling pathway
is_a: GO:0048010 ! vascular endothelial growth factor receptor signaling pathway
is_a: GO:2001028 ! positive regulation of endothelial cell chemotaxis
created_by: rfoulger
creation_date: 2011-09-19T02:36:37Z

[Term]
id: GO:0038034
name: signal transduction in absence of ligand
namespace: biological_process
def: "A series of molecular signals initiated by the absence of a ligand or the withdrawal of a ligand from a receptor." [GOC:al, GOC:ppm, GOC:pr, PMID:15044679]
synonym: "addiction receptor signaling pathway" BROAD [PMID:15044679]
synonym: "basal signaling" NARROW [GOC:al]
synonym: "dependence receptor signaling pathway" BROAD [PMID:15044679]
synonym: "negative signal transduction" RELATED [PMID:15044679]
synonym: "non-classical signal transduction" BROAD [PMID:15044679]
synonym: "signal transduction in absence of agonist" EXACT [GOC:bf]
is_a: GO:0007165 ! signal transduction
created_by: rfoulger
creation_date: 2011-10-26T02:21:03Z

[Term]
id: GO:0038035
name: G-protein coupled receptor signaling in absence of ligand
namespace: biological_process
def: "A series of molecular signals beginning with a G-protein coupled receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex, where the G-protein coupled receptor is not bound to an agonist." [GOC:al, PMID:12402500, PMID:17629961]
comment: This term is intended for use by G-protein coupled receptors which signal at a low-level in the absence of agonist binding.
synonym: "basal G-protein coupled receptor signaling" NARROW [GOC:al]
synonym: "G-protein coupled receptor signaling in absence of agonist" EXACT [GOC:bf]
synonym: "G-protein coupled receptor signalling in absence of ligand" EXACT [GOC:mah]
is_a: GO:0007186 ! G-protein coupled receptor signaling pathway
is_a: GO:0038034 ! signal transduction in absence of ligand
created_by: rfoulger
creation_date: 2011-10-26T02:31:37Z

[Term]
id: GO:0038036
name: sphingosine-1-phosphate receptor activity
namespace: molecular_function
def: "Combining with the sphingolipid sphingosine-1-phosphate (S1P), and transmitting the signal across the membrane by activating an associated G-protein." [GOC:bf, PMID:12728273, Wikipedia:S1PR1]
synonym: "S1P receptor activity" EXACT [Wikipedia:Sphingosine_1-phosphate]
is_a: GO:0045125 ! bioactive lipid receptor activity
relationship: part_of GO:0003376 ! sphingosine-1-phosphate signaling pathway
created_by: rfoulger
creation_date: 2011-10-28T03:46:54Z

[Term]
id: GO:0038037
name: G-protein coupled receptor dimeric complex
namespace: cellular_component
def: "A protein complex that contains two G-protein coupled receptors." [GOC:al, GOC:bf, PMID:10713101]
synonym: "G-protein coupled receptor dimer" EXACT [GOC:bf]
synonym: "GPCR dimer" EXACT [GOC:bf]
is_a: GO:0097648 ! G-protein coupled receptor complex
created_by: rfoulger
creation_date: 2011-11-02T04:42:44Z

[Term]
id: GO:0038038
name: G-protein coupled receptor homodimeric complex
namespace: cellular_component
def: "A protein complex that contains two G-protein coupled receptors (GPCRs) of the same subtype. Formation of a GPCR homodimer may be important for the transport of newly formed receptors to the cell surface, and the function of the receptor." [GOC:al, GOC:bf, PMID:10713101, PMID:16670762]
synonym: "G-protein coupled receptor homodimer" EXACT [GOC:bf]
synonym: "GPCR homodimer" EXACT [GOC:bf]
is_a: GO:0038037 ! G-protein coupled receptor dimeric complex
created_by: rfoulger
creation_date: 2011-11-02T04:43:53Z

[Term]
id: GO:0038039
name: G-protein coupled receptor heterodimeric complex
namespace: cellular_component
def: "A protein complex that contains two G-protein coupled receptors (GPCRs) of different subtypes. Formation of a GPCR heterodimer may alter the functional property of the GPCR." [GOC:al, GOC:bf, PMID:16109836, PMID:20150590]
synonym: "G-protein coupled receptor heterodimer" EXACT [GOC:bf]
synonym: "GPCR heterodimer" EXACT [PMID:20150590]
is_a: GO:0038037 ! G-protein coupled receptor dimeric complex
created_by: rfoulger
creation_date: 2011-11-02T04:44:20Z

[Term]
id: GO:0038040
name: cross-receptor activation within G-protein coupled receptor heterodimer
namespace: biological_process
def: "Activation of one protomer of a G-protein coupled receptor (GPCR) heterodimer by the associated subunit. For example, agonist occupancy in one protomer of a GPCR dimer may activate the associated promoter." [GOC:al, GOC:bf, PMID:21063387]
is_a: GO:0035624 ! receptor transactivation
is_a: GO:0045745 ! positive regulation of G-protein coupled receptor protein signaling pathway
relationship: positively_regulates GO:0038042 ! dimeric G-protein coupled receptor signaling pathway
created_by: rfoulger
creation_date: 2011-11-02T04:50:22Z

[Term]
id: GO:0038041
name: cross-receptor inhibition within G-protein coupled receptor heterodimer
namespace: biological_process
def: "Inhibition of one protomer of a G-protein coupled receptor (GPCR) heterodimer by the associated subunit. For example, agonist activation of one cytokine receptor can prevent activation of its associated cytokine receptor subunit." [GOC:al, GOC:bf, PMID:15979374]
is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:2000272 ! negative regulation of receptor activity
relationship: regulates GO:0038042 ! dimeric G-protein coupled receptor signaling pathway
created_by: rfoulger
creation_date: 2011-11-02T04:52:24Z

[Term]
id: GO:0038042
name: dimeric G-protein coupled receptor signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by an extracellular signal combining with a dimeric receptor on the surface of the target cell, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. Heterodimeric and homodimeric GPCRs may have different functional properties from those of the respective monomers." [GOC:al, GOC:bf, PMID:15979374, PMID:21063387]
synonym: "dimeric G-protein coupled receptor signalling pathway" EXACT [GOC:mah]
synonym: "G-protein coupled receptor signaling pathway via GPCR dimer" EXACT [GOC:bf]
is_a: GO:0007186 ! G-protein coupled receptor signaling pathway
created_by: rfoulger
creation_date: 2011-11-02T04:56:02Z

[Term]
id: GO:0038043
name: interleukin-5-mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of interleukin-5 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:pg, GOC:signaling, PR:000001392]
synonym: "IL-5-mediated signaling pathway" EXACT [GOC:bf]
synonym: "interleukin-5-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0019221 ! cytokine-mediated signaling pathway
created_by: rfoulger
creation_date: 2011-11-03T04:18:21Z

[Term]
id: GO:0038044
name: transforming growth factor-beta secretion
namespace: biological_process
def: "The regulated release of transforming growth factor-beta (TGF-beta) from a cell into the extracellular region. TGF-beta is mostly secreted as a large latent TGF-beta complex (LLC) containing latency-associated proteins (LAPs) derived from the N-terminal region of the TGF-beta gene product, dimeric TGF-beta and latent TGF-beta binding proteins (LTBPs)." [GOC:bf, GOC:yaf, PMID:2350783, Reactome:REACT_6888.1]
synonym: "TGF-beta secretion" EXACT [PMID:2022183]
synonym: "TGFbeta secretion" EXACT [PMID:16891311]
is_a: GO:0050663 ! cytokine secretion
created_by: rfoulger
creation_date: 2011-11-03T04:23:35Z

[Term]
id: GO:0038045
name: large latent transforming growth factor-beta complex
namespace: cellular_component
def: "A protein complex containing latency-associated proteins (LAPs), mature disulphide-linked dimeric TGF-beta, and latent TGF-beta binding proteins (LTBPs). TGF-beta is mostly secreted as part of the large latent complex, and must be subsequently released from the LLC in order to bind to cell surface receptors." [GOC:bf, PMID:2350783, PMID:8680476, PMID:9805445, Reactome:REACT_6888.1]
synonym: "large latent complex" EXACT [Reactome:REACT_6888.1]
synonym: "LLC" EXACT [Reactome:REACT_6888.1]
is_a: GO:0043234 ! protein complex
created_by: rfoulger
creation_date: 2011-11-03T04:29:49Z

[Term]
id: GO:0038046
name: enkephalin receptor activity
namespace: molecular_function
def: "Combining with an enkephalin, and transmitting the signal across the membrane by activating an associated G-protein. A enkephalin is a pentapeptide (Tyr-Gly-Gly-Phe-Met or Tyr-Gly-Gly-Phe-Leu) involved in regulating nociception in the body." [GOC:bf, Wikipedia:Enkephalin]
synonym: "delta-opioid receptor activity" RELATED [GOC:bf]
is_a: GO:0004985 ! opioid receptor activity
created_by: rfoulger
creation_date: 2011-11-14T01:30:14Z

[Term]
id: GO:0038047
name: morphine receptor activity
namespace: molecular_function
def: "Combining with morphine (17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol), and transmitting the signal across the membrane by activating an associated G-protein." [CHEBI:17303, GOC:bf]
synonym: "mu-opioid receptor activity" RELATED [GOC:bf]
is_a: GO:0004985 ! opioid receptor activity
relationship: part_of GO:0071315 ! cellular response to morphine
created_by: rfoulger
creation_date: 2011-11-14T01:35:18Z

[Term]
id: GO:0038048
name: dynorphin receptor activity
namespace: molecular_function
def: "Combining with a dynorphin peptide, and transmitting the signal across the membrane by activating an associated G-protein. Dynorphin is any opioid peptide that is generated by cleavage of the precursor protein prodynorphin." [GOC:bf, Wikipedia:Dynorphin]
synonym: "kappa-opioid receptor activity" RELATED [GOC:bf]
is_a: GO:0004985 ! opioid receptor activity
created_by: rfoulger
creation_date: 2011-11-14T01:48:02Z

[Term]
id: GO:0038049
name: transcription factor activity, ligand-activated RNA polymerase II transcription factor binding
namespace: molecular_function
def: "Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. For example, some steroid hormone receptors bind to transcription factor complexes to regulate transcription of genes whose promoters do not contain hormone response elements." [GOC:signaling, GOC:txnOH]
comment: GO:0038049 is intended for annotation of nuclear receptors that regulate transcription by binding to transcription factors or transcription factor complexes. When the nuclear receptor functions by binding directly to DNA response elements, consider instead annotating to 'ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity ; GO:0004879'.
synonym: "ligand-activated nuclear receptor activity" RELATED [GOC:bf]
synonym: "ligand-activated RNA polymerase II transcription factor binding transcription factor activity" EXACT []
synonym: "ligand-dependent transcription factor activity" RELATED [GOC:bf]
is_a: GO:0001076 ! transcription factor activity, RNA polymerase II transcription factor binding
is_a: GO:0038023 ! signaling receptor activity
relationship: part_of GO:0030522 ! intracellular receptor signaling pathway
created_by: rfoulger
creation_date: 2011-11-29T01:53:30Z

[Term]
id: GO:0038050
name: RNA polymerase II transcription factor activity, glucocorticoid-activated sequence-specific DNA binding
namespace: molecular_function
def: "Combining with a glucocorticoid and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II." [GOC:signaling, PMID:17689856]
comment: For glucocorticoid receptors that function by binding to other transcription factors, consider instead annotating to 'glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity ; GO:0038051'.
synonym: "glucocorticoid receptor activity" BROAD [GOC:bf]
synonym: "glucocorticoid-activated sequence-specific DNA binding RNA polymerase II transcription factor activity" EXACT []
is_a: GO:0004879 ! RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
is_a: GO:0004883 ! glucocorticoid receptor activity
created_by: rfoulger
creation_date: 2011-11-29T02:29:18Z

[Term]
id: GO:0038051
name: glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity
namespace: molecular_function
def: "Combining with a glucocorticoid and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. For example, glucocorticoid-bound receptors can bind to transcription factor complexes to regulate transcription of genes whose promoters do not contain glucocorticoid response elements." [GOC:signaling, PMID:17689856]
comment: For glucocorticoid receptors that function by binding response elements in DNA, consider instead annotating to 'glucocorticoid-activated sequence-specific DNA binding RNA polymerase II transcription factor activity ; GO:0038050'.
synonym: "glucocorticoid receptor activity" BROAD [GOC:bf]
is_a: GO:0004883 ! glucocorticoid receptor activity
is_a: GO:0038049 ! transcription factor activity, ligand-activated RNA polymerase II transcription factor binding
created_by: rfoulger
creation_date: 2011-11-29T02:30:46Z

[Term]
id: GO:0038052
name: RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding
namespace: molecular_function
def: "Combining with estrogen and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II." [GOC:signaling, PMID:17615392]
comment: For estrogen receptors that function by binding to other transcription factors, consider instead annotating to 'estrogen-activated RNA polymerase II transcription factor binding transcription factor activity ; GO:0038053'.
synonym: "estrogen nuclear receptor activity" BROAD [GOC:bf]
synonym: "estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity" EXACT []
is_a: GO:0004879 ! RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
is_a: GO:0030284 ! estrogen receptor activity
relationship: part_of GO:0030520 ! intracellular estrogen receptor signaling pathway
created_by: rfoulger
creation_date: 2011-11-29T02:41:48Z

[Term]
id: GO:0038053
name: transcription factor activity, estrogen-activated RNA polymerase II transcription factor binding
namespace: molecular_function
def: "Combining with estrogen and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. For example, estrogen-bound receptors can bind to transcription factor complexes to regulate transcription of genes whose promoters do not contain estrogen response elements." [GOC:signaling, PMID:17615392]
comment: For estrogen receptors that function by binding response elements in DNA, consider instead annotating to 'estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity ; GO:0038052'.
synonym: "estrogen nuclear receptor activity" BROAD [GOC:bf]
synonym: "estrogen-activated RNA polymerase II transcription factor binding transcription factor activity" EXACT []
is_a: GO:0030284 ! estrogen receptor activity
is_a: GO:0038049 ! transcription factor activity, ligand-activated RNA polymerase II transcription factor binding
relationship: part_of GO:0030520 ! intracellular estrogen receptor signaling pathway
created_by: rfoulger
creation_date: 2011-11-29T02:42:22Z

[Term]
id: GO:0038054
name: G-protein coupled estrogen receptor activity
namespace: molecular_function
def: "Combining with estrogen and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:signaling, PMID:17379646, PMID:20960099]
is_a: GO:0004930 ! G-protein coupled receptor activity
is_a: GO:0030284 ! estrogen receptor activity
created_by: rfoulger
creation_date: 2011-11-29T04:29:42Z

[Term]
id: GO:0038055
name: BMP secretion
namespace: biological_process
def: "The controlled release of a member of the BMP family of proteins from a cell." [GOC:sart, PR:000000034]
synonym: "BMP protein secretion" EXACT [GOC:bf]
synonym: "bone morphogenetic protein secretion" EXACT [GOC:bf]
is_a: GO:0009306 ! protein secretion
is_a: GO:0023061 ! signal release
created_by: rfoulger
creation_date: 2011-12-14T02:31:39Z

[Term]
id: GO:0038056
name: negative regulation of BMP signaling pathway by negative regulation of BMP secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway by stopping, preventing or reducing the frequency, rate or extent of secretion of a member of the BMP family of proteins from the signaling cell." [GOC:bf, GOC:sart, PMID:21750037]
synonym: "negative regulation of BMP signaling pathway by negative regulation of bone morphogenetic protein secretion" EXACT [GOC:bf]
synonym: "negative regulation of BMP signalling pathway by negative regulation of BMP secretion" EXACT [GOC:bf]
is_a: GO:0030514 ! negative regulation of BMP signaling pathway
is_a: GO:2001285 ! negative regulation of BMP secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030509 ! BMP signaling pathway
intersection_of: negatively_regulates GO:0038055 ! BMP secretion
relationship: negatively_regulates GO:0030509 ! BMP signaling pathway
relationship: negatively_regulates GO:0038055 ! BMP secretion
created_by: rfoulger
creation_date: 2011-12-19T10:55:47Z

[Term]
id: GO:0038057
name: TNFSF11 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with tumor necrosis factor ligand superfamily member 11 (TNFSF11), a member of the tumor necrosis factor (TNF) cytokine family." [GOC:cjm, PR:000002107]
synonym: "CD254 binding" EXACT [GOC:sl, PR:000002107]
synonym: "ODF binding" EXACT [GOC:sl, PR:000002107]
synonym: "OPGL binding" EXACT [GOC:sl, PR:000002107]
synonym: "osteoclast differentiation factor binding" EXACT [GOC:sl, PR:000002107]
synonym: "osteoprotegerin ligand binding" EXACT [GOC:sl, PR:000002107]
synonym: "RANKL binding" EXACT [GOC:sl, PR:000002107]
synonym: "receptor activator of nuclear factor kappa-B ligand binding" EXACT [GOC:sl, PR:000002107]
synonym: "TNF-related activation-induced cytokine binding" EXACT [GOC:sl, PR:000002107]
synonym: "TRANCE binding" EXACT [GOC:sl, PR:000002107]
synonym: "tumor necrosis factor (ligand) superfamily member 11 binding" EXACT [GOC:bf]
synonym: "tumor necrosis factor ligand superfamily member 11 binding" EXACT [PR:000002107]
synonym: "tumor necrosis factor superfamily member 11 binding" EXACT [GOC:bf]
is_a: GO:0043120 ! tumor necrosis factor binding
created_by: rfoulger
creation_date: 2012-01-04T03:25:59Z

[Term]
id: GO:0038058
name: TNFSF11 receptor activity
namespace: molecular_function
def: "Combining with a tumor necrosis factor ligand superfamily member 11 (TNFSF11) and transmitting the signal across the cell membrane to initiate a change in cell activity or function." [GOC:bf, GOC:cjm, PR:000002107]
synonym: "RANKL receptor activity" EXACT [PR:000002107, Wikipedia:RANKL]
synonym: "tumor necrosis factor ligand superfamily member 11 receptor activity" EXACT [PR:000002107, Wikipedia:RANKL]
is_a: GO:0005031 ! tumor necrosis factor-activated receptor activity
relationship: has_part GO:0038057 ! TNFSF11 binding
relationship: part_of GO:0071847 ! TNFSF11-mediated signaling pathway
created_by: rfoulger
creation_date: 2012-01-04T03:31:54Z

[Term]
id: GO:0038059
name: IKKalpha-IKKalpha complex
namespace: cellular_component
def: "A homodimeric protein complex containing two IkappaB kinase (IKK) alpha subunits." [GOC:bf, PMID:18626576, PMID:21173796]
synonym: "IkappaB kinase alpha homodimer" EXACT [GOC:bf]
synonym: "IkappaB kinase-alpha homodimer" EXACT [PMID:21173796]
synonym: "IKKalpha homodimer" EXACT [GOC:bf]
synonym: "IKKalpha homodimeric complex" EXACT [GOC:bf]
synonym: "IKKalpha-IKKalpha protein complex" EXACT [GOC:bf]
is_a: GO:0043234 ! protein complex
created_by: rfoulger
creation_date: 2012-01-10T09:29:53Z

[Term]
id: GO:0038060
name: nitric oxide-cGMP-mediated signaling pathway
namespace: biological_process
def: "Any intracellular signal transduction in which the signal is passed on within the cell by nitric oxide (NO) activating soluble guanylyl cyclase (sGC). Includes synthesis of nitric oxide, guanylyl cyclase activity, and downstream effectors that further transmit the signal within the cell following activation by cGMP." [GOC:signaling, PMID:21549190, PMID:22019632]
synonym: "canonical nitric oxide signaling" EXACT [GOC:bf]
synonym: "classical nitric oxide signaling" EXACT [PMID:21549190]
synonym: "nitric oxide-cGMP-mediated signalling pathway" EXACT [GOC:mah]
synonym: "NO-cGMP signaling pathway" EXACT [PMID:22019632]
is_a: GO:0007263 ! nitric oxide mediated signal transduction
is_a: GO:0019934 ! cGMP-mediated signaling
created_by: rfoulger
creation_date: 2012-01-10T05:32:39Z

[Term]
id: GO:0038061
name: NIK/NF-kappaB signaling
namespace: biological_process
def: "The process in which a signal is passed on to downstream components within the cell through the NIK-dependent processing and activation of NF-KappaB. Begins with activation of the NF-KappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-Kappa B2 protein (p100) leading to p100 processing and release of an active NF-KappaB (p52)." [GOC:bf, GOC:mg2, GOC:signaling, GOC:vs, PMID:11239468, PMID:15140882]
synonym: "NIK/NF-kappaB cascade" RELATED [GOC:signaling]
synonym: "NIK/NF-kappaB signal transduction" EXACT [GOC:signaling]
synonym: "non-canonical NF-KB signaling" BROAD [PMID:21173796]
synonym: "noncanonical NF-kappaB signaling" BROAD [PMID:20501935]
synonym: "noncanonical nuclear factor kappaB (NF-kappaB) pathway" BROAD [PMID:20501935]
synonym: "p52-dependent NF-kappaB signaling" NARROW [PMID:18292232]
is_a: GO:0035556 ! intracellular signal transduction
relationship: has_part GO:0051092 ! positive regulation of NF-kappaB transcription factor activity
created_by: rfoulger
creation_date: 2012-01-16T05:44:46Z

[Term]
id: GO:0038062
name: protein tyrosine kinase collagen receptor activity
namespace: molecular_function
def: "Combining with collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [GOC:bf, GOC:uh, PMID:16626936, PMID:21568710]
synonym: "collagen RTK activity" EXACT [PMID:21568710]
synonym: "discoidin domain receptor" RELATED [PMID:16626936]
is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity
is_a: GO:0038064 ! collagen receptor activity
relationship: part_of GO:0038063 ! collagen-activated tyrosine kinase receptor signaling pathway
created_by: rfoulger
creation_date: 2012-01-18T01:38:40Z

[Term]
id: GO:0038063
name: collagen-activated tyrosine kinase receptor signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of collagen to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:uh, PMID:15888913, PMID:16626936]
synonym: "collagen-activated RTK signaling pathway" EXACT [PMID:21568710]
synonym: "collagen-activated tyrosine kinase receptor signalling pathway" EXACT [GOC:mah]
synonym: "DDR signaling pathway" NARROW [PMID:16626936]
synonym: "discoidin domain receptor signaling pathway" NARROW [PMID:16626936]
is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway
is_a: GO:0038065 ! collagen-activated signaling pathway
created_by: rfoulger
creation_date: 2012-01-18T01:43:20Z

[Term]
id: GO:0038064
name: collagen receptor activity
namespace: molecular_function
def: "Combining with a collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, GOC:uh, PMID:21568710]
synonym: "transmembrane collagen receptor activity" EXACT [PMID:21568710]
is_a: GO:0004888 ! transmembrane signaling receptor activity
relationship: has_part GO:0005518 ! collagen binding
relationship: part_of GO:0038065 ! collagen-activated signaling pathway
created_by: rfoulger
creation_date: 2012-01-18T01:52:42Z

[Term]
id: GO:0038065
name: collagen-activated signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by collagen binding to a cell surface receptor, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:uh, PMID:21568710]
synonym: "collagen-activated signalling pathway" EXACT [GOC:mah]
is_a: GO:0007166 ! cell surface receptor signaling pathway
created_by: rfoulger
creation_date: 2012-01-18T01:57:37Z

[Term]
id: GO:0038066
name: p38MAPK cascade
namespace: biological_process
def: "An intracellular protein kinase cascade containing at least a p38 MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell." [GOC:signaling, PMID:20811974]
synonym: "p38 cascade" EXACT [PMID:20811974]
synonym: "p38 MAPK cascade" EXACT [GOC:bf]
is_a: GO:0051403 ! stress-activated MAPK cascade
created_by: rfoulger
creation_date: 2012-01-25T11:51:24Z

[Term]
id: GO:0038067
name: MAP kinase activity involved in cell wall organization or biogenesis
namespace: molecular_function
def: "Catalysis of the reaction: protein + ATP = protein phosphate + ADP by a mitogen-activated protein kinase, as part of a MAPK signaling cascade that contributes to cell wall organization or biogenesis." [GOC:signaling]
synonym: "MAP kinase activity involved in cell wall biogenesis" NARROW []
synonym: "MAP kinase activity involved in cell wall integrity" RELATED [GOC:vw]
synonym: "MAPK activity involved in cell wall biogenesis" NARROW [GOC:signaling]
is_a: GO:0004707 ! MAP kinase activity
intersection_of: GO:0004707 ! MAP kinase activity
intersection_of: part_of GO:0000196 ! MAPK cascade involved in cell wall organization or biogenesis
relationship: part_of GO:0000196 ! MAPK cascade involved in cell wall organization or biogenesis
created_by: rfoulger
creation_date: 2012-01-25T03:29:04Z

[Term]
id: GO:0038068
name: MAP kinase kinase activity involved in cell wall organization or biogenesis
namespace: molecular_function
def: "Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate, as part of a MAPK signaling cascade that contributes to cell wall organization or biogenesis." [GOC:signaling]
synonym: "MAP kinase kinase activity involved in cell wall biogenesis" NARROW [GOC:vw]
synonym: "MAP2K activity involved in cell wall integrity" EXACT [GOC:bf]
synonym: "MAPKK activity involved in cell wall integrity" EXACT [GOC:bf]
is_a: GO:0004708 ! MAP kinase kinase activity
intersection_of: GO:0004708 ! MAP kinase kinase activity
intersection_of: part_of GO:0000196 ! MAPK cascade involved in cell wall organization or biogenesis
relationship: part_of GO:0000196 ! MAPK cascade involved in cell wall organization or biogenesis
relationship: part_of GO:0000199 ! activation of MAPK activity involved in cell wall organization or biogenesis
created_by: rfoulger
creation_date: 2012-01-25T03:34:10Z

[Term]
id: GO:0038069
name: MAP kinase phosphatase activity involved in regulation of cell wall biogenesis
namespace: molecular_function
def: "Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate, where the MAP kinase (MAPK) is part of a MAPK signaling cascade that contributes to cell wall biogenesis." [GOC:signaling]
synonym: "Mpk1 phosphatase activity" NARROW [PMID:10523653]
synonym: "Slt2 phosphatase activity" NARROW [PMID:10523653]
is_a: GO:0033549 ! MAP kinase phosphatase activity
relationship: part_of GO:0000200 ! inactivation of MAPK activity involved in cell wall organization or biogenesis
created_by: rfoulger
creation_date: 2012-01-25T03:38:58Z

[Term]
id: GO:0038070
name: MAP kinase kinase kinase activity involved in cell wall organization or biogenesis
namespace: molecular_function
def: "Catalysis of the phosphorylation and activation of a MAP kinase kinase (MAPKK), as part of a MAPK signaling cascade that contributes to cell wall organization or biogenesis." [GOC:signaling]
synonym: "MAP kinase kinase kinase activity involved in cell wall biogenesis" EXACT [GOC:vw]
synonym: "MAP3K activity involved in cell wall integrity" EXACT [GOC:bf]
synonym: "MAPKKK activity involved in cell wall integrity" EXACT [GOC:bf]
is_a: GO:0004709 ! MAP kinase kinase kinase activity
intersection_of: GO:0004709 ! MAP kinase kinase kinase activity
intersection_of: part_of GO:0000196 ! MAPK cascade involved in cell wall organization or biogenesis
relationship: part_of GO:0000196 ! MAPK cascade involved in cell wall organization or biogenesis
relationship: part_of GO:0000198 ! activation of MAPKK activity involved in cell wall organization or biogenesis
created_by: rfoulger
creation_date: 2012-01-25T03:43:46Z

[Term]
id: GO:0038071
name: MAP kinase activity involved in conjugation with cellular fusion
namespace: molecular_function
def: "Catalysis of the reaction: protein + ATP = protein phosphate + ADP by a mitogen-activated protein kinase, as part of a MAPK signaling cascade that contributes to conjugation with cellular fusion." [GOC:signaling]
synonym: "MAPK activity involved in conjugation with cellular fusion" EXACT [GOC:signaling]
is_a: GO:0004707 ! MAP kinase activity
intersection_of: GO:0004707 ! MAP kinase activity
intersection_of: part_of GO:0071507 ! MAPK cascade involved in conjugation with cellular fusion
relationship: part_of GO:0071507 ! MAPK cascade involved in conjugation with cellular fusion
created_by: rfoulger
creation_date: 2012-01-26T02:31:57Z

[Term]
id: GO:0038072
name: MAP kinase kinase activity involved in conjugation with cellular fusion
namespace: molecular_function
def: "Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate, as part of a MAPK signaling cascade that contributes to conjugation with cellular fusion." [GOC:signaling]
synonym: "MAP2K activity involved in conjugation with cellular fusion" EXACT [GOC:signaling]
synonym: "MAPKK activity involved in conjugation with cellular fusion" EXACT [GOC:signaling]
is_a: GO:0004708 ! MAP kinase kinase activity
intersection_of: GO:0004708 ! MAP kinase kinase activity
intersection_of: part_of GO:0071507 ! MAPK cascade involved in conjugation with cellular fusion
relationship: part_of GO:0071507 ! MAPK cascade involved in conjugation with cellular fusion
relationship: part_of GO:0071508 ! activation of MAPK activity involved in conjugation with cellular fusion
created_by: rfoulger
creation_date: 2012-01-26T02:31:57Z

[Term]
id: GO:0038073
name: MAP kinase kinase kinase activity involved in conjugation with cellular fusion
namespace: molecular_function
def: "Catalysis of the phosphorylation and activation of a MAP kinase kinase (MAPKK), as part of a MAPK signaling cascade that contributes to cell wall biogenesis." [GOC:signaling]
synonym: "MAP3K activity involved in conjugation with cellular fusion" EXACT [GOC:signaling]
synonym: "MAPKKK activity involved in conjugation with cellular fusion" EXACT [GOC:signaling]
is_a: GO:0004709 ! MAP kinase kinase kinase activity
intersection_of: GO:0004709 ! MAP kinase kinase kinase activity
intersection_of: part_of GO:0071507 ! MAPK cascade involved in conjugation with cellular fusion
relationship: part_of GO:0071507 ! MAPK cascade involved in conjugation with cellular fusion
relationship: part_of GO:0071509 ! activation of MAPKK activity involved in conjugation with cellular fusion
created_by: rfoulger
creation_date: 2012-01-26T02:31:57Z

[Term]
id: GO:0038074
name: MAP kinase phosphatase activity involved in regulation of conjugation with cellular fusion
namespace: molecular_function
def: "Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate, where the MAP kinase (MAPK) is part of a MAPK signaling cascade that contributes to conjugation with cellular fusion." [GOC:signaling]
synonym: "MAPK phosphatase activity involved in regulation of conjugation with cellular fusion" EXACT [GOC:bf]
is_a: GO:0033549 ! MAP kinase phosphatase activity
intersection_of: GO:0033549 ! MAP kinase phosphatase activity
intersection_of: part_of GO:0031137 ! regulation of conjugation with cellular fusion
relationship: part_of GO:0031137 ! regulation of conjugation with cellular fusion
relationship: part_of GO:0071511 ! inactivation of MAPK activity involved in conjugation with cellular fusion
created_by: rfoulger
creation_date: 2012-01-26T02:31:57Z

[Term]
id: GO:0038075
name: MAP kinase activity involved in innate immune response
namespace: molecular_function
def: "Catalysis of the reaction: protein + ATP = protein phosphate + ADP by a mitogen-activated protein kinase, as part of a MAPK signaling cascade that contributes to an innate immune response." [GOC:signaling]
synonym: "MAPK activity involved in innate immune response" EXACT [GOC:signaling]
is_a: GO:0004707 ! MAP kinase activity
intersection_of: GO:0004707 ! MAP kinase activity
intersection_of: part_of GO:0035420 ! MAPK cascade involved in innate immune response
relationship: part_of GO:0035420 ! MAPK cascade involved in innate immune response
created_by: rfoulger
creation_date: 2012-01-26T02:35:52Z

[Term]
id: GO:0038076
name: MAP kinase kinase activity involved in innate immune response
namespace: molecular_function
def: "Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate, as part of a MAPK signaling cascade that contributes to an innate immune response." [GOC:signaling]
synonym: "MAP2K activity involved in innate immune response" EXACT [GOC:signaling]
synonym: "MAPKK activity involved in innate immune response" EXACT [GOC:signaling]
is_a: GO:0004708 ! MAP kinase kinase activity
intersection_of: GO:0004708 ! MAP kinase kinase activity
intersection_of: part_of GO:0035420 ! MAPK cascade involved in innate immune response
relationship: part_of GO:0035419 ! activation of MAPK activity involved in innate immune response
relationship: part_of GO:0035420 ! MAPK cascade involved in innate immune response
created_by: rfoulger
creation_date: 2012-01-26T02:35:52Z

[Term]
id: GO:0038077
name: MAP kinase kinase kinase activity involved in innate immune response
namespace: molecular_function
def: "Catalysis of the phosphorylation and activation of a MAP kinase kinase (MAPKK), as part of a MAPK signaling cascade that contributes to an innate immune response." [GOC:signaling]
synonym: "MAP3K activity involved in innate immune response" EXACT [GOC:signaling]
synonym: "MAPKKK activity involved in innate immune response" EXACT [GOC:signaling]
is_a: GO:0004709 ! MAP kinase kinase kinase activity
intersection_of: GO:0004709 ! MAP kinase kinase kinase activity
intersection_of: part_of GO:0035420 ! MAPK cascade involved in innate immune response
relationship: part_of GO:0035420 ! MAPK cascade involved in innate immune response
relationship: part_of GO:0035421 ! activation of MAPKK activity involved in innate immune response
created_by: rfoulger
creation_date: 2012-01-26T02:35:52Z

[Term]
id: GO:0038078
name: MAP kinase phosphatase activity involved in regulation of innate immune response
namespace: molecular_function
def: "Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate, where the MAP kinase (MAPK) is part of a MAPK signaling cascade that contributes to an innate immune response." [GOC:signaling]
synonym: "MAPK phosphatase activity involved in regulation of innate immune response" EXACT [GOC:bf]
is_a: GO:0004871 ! signal transducer activity
is_a: GO:0033549 ! MAP kinase phosphatase activity
intersection_of: GO:0033549 ! MAP kinase phosphatase activity
intersection_of: part_of GO:0045088 ! regulation of innate immune response
relationship: part_of GO:0035423 ! inactivation of MAPK activity involved in innate immune response
relationship: part_of GO:0045088 ! regulation of innate immune response
created_by: rfoulger
creation_date: 2012-01-26T02:35:52Z

[Term]
id: GO:0038079
name: MAP kinase activity involved in osmosensory signaling pathway
namespace: molecular_function
def: "Catalysis of the reaction: protein + ATP = protein phosphate + ADP by a mitogen-activated protein kinase, as part of a MAPK signaling cascade that passes on a signal within an osmosensory signaling pathway." [GOC:signaling]
synonym: "MAP kinase activity involved in osmosensory signalling pathway" EXACT [GOC:mah]
synonym: "MAPK activity involved in osmosensory signaling pathway" EXACT [GOC:signaling]
is_a: GO:0004707 ! MAP kinase activity
intersection_of: GO:0004707 ! MAP kinase activity
intersection_of: part_of GO:0000161 ! MAPK cascade involved in osmosensory signaling pathway
relationship: part_of GO:0000161 ! MAPK cascade involved in osmosensory signaling pathway
created_by: rfoulger
creation_date: 2012-01-26T02:41:31Z

[Term]
id: GO:0038080
name: MAP kinase kinase activity involved in osmosensory signaling pathway
namespace: molecular_function
def: "Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate, as part of a MAPK signaling cascade that passes on a signal within an osmosensory signaling pathway." [GOC:signaling]
synonym: "MAP kinase kinase activity involved in osmosensory signalling pathway" EXACT [GOC:mah]
synonym: "MAP2K activity involved in osmosensory signaling pathway" EXACT [GOC:signaling]
synonym: "MAPKK activity involved in osmosensory signaling pathway" EXACT [GOC:signaling]
is_a: GO:0004708 ! MAP kinase kinase activity
intersection_of: GO:0004708 ! MAP kinase kinase activity
intersection_of: part_of GO:0000161 ! MAPK cascade involved in osmosensory signaling pathway
relationship: part_of GO:0000161 ! MAPK cascade involved in osmosensory signaling pathway
relationship: part_of GO:0000169 ! activation of MAPK activity involved in osmosensory signaling pathway
created_by: rfoulger
creation_date: 2012-01-26T02:41:31Z

[Term]
id: GO:0038081
name: MAP kinase kinase kinase activity involved in osmosensory signaling pathway
namespace: molecular_function
def: "Catalysis of the phosphorylation and activation of a MAP kinase kinase (MAPKK), as part of a MAPK signaling cascade that passes on a signal within an osmosensory signaling pathway." [GOC:signaling]
synonym: "MAP kinase kinase kinase activity involved in osmosensory signalling pathway" EXACT [GOC:mah]
synonym: "MAP3K activity involved in osmosensory signaling pathway" EXACT [GOC:signaling]
synonym: "MAPKKK activity involved in osmosensory signaling pathway" EXACT [GOC:signaling]
is_a: GO:0004709 ! MAP kinase kinase kinase activity
intersection_of: GO:0004709 ! MAP kinase kinase kinase activity
intersection_of: part_of GO:0000161 ! MAPK cascade involved in osmosensory signaling pathway
relationship: part_of GO:0000161 ! MAPK cascade involved in osmosensory signaling pathway
relationship: part_of GO:0000168 ! activation of MAPKK activity involved in osmosensory signaling pathway
created_by: rfoulger
creation_date: 2012-01-26T02:41:31Z

[Term]
id: GO:0038082
name: MAP kinase phosphatase activity involved in regulation of osmosensory signaling pathway
namespace: molecular_function
def: "Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate, where the MAP kinase (MAPK) is part of a MAPK signaling cascade that passes on a signal within an osmosensory signaling pathway." [GOC:signaling]
synonym: "Hog1 phosphatase activity" NARROW [PMID:20880736]
synonym: "MAP kinase phosphatase activity involved in regulation of osmosensory signalling pathway" EXACT [GOC:mah]
synonym: "MAPK phosphatase activity involved in regulation of osmosensory signaling pathway" EXACT [GOC:bf]
is_a: GO:0033549 ! MAP kinase phosphatase activity
intersection_of: GO:0033549 ! MAP kinase phosphatase activity
intersection_of: part_of GO:0047484 ! regulation of response to osmotic stress
relationship: part_of GO:0000173 ! inactivation of MAPK activity involved in osmosensory signaling pathway
relationship: part_of GO:0047484 ! regulation of response to osmotic stress
created_by: rfoulger
creation_date: 2012-01-26T02:41:31Z

[Term]
id: GO:0038083
name: peptidyl-tyrosine autophosphorylation
namespace: biological_process
def: "The phosphorylation by a protein of one or more of its own tyrosine amino acid residues, or a tyrosine residue on an identical protein." [PMID:10037737, PMID:10068444, PMID:10940390]
synonym: "receptor tyrosine kinase autophosphorylation" NARROW [PMID:20432069]
synonym: "RTK autophosphorylation" NARROW [PMID:20432069]
synonym: "tyrosine autophosphorylation" EXACT [PMID:16431914]
is_a: GO:0018108 ! peptidyl-tyrosine phosphorylation
is_a: GO:0046777 ! protein autophosphorylation
created_by: rfoulger
creation_date: 2012-02-01T02:14:18Z

[Term]
id: GO:0038084
name: vascular endothelial growth factor signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, PMID:17470632, PR:000003096, PR:000007520, PR:000017284, PR:000017285]
comment: In GO, a gene product with 'vascular endothelial growth factor-activated receptor activity ; GO:0005021' necessarily binds VEGF to transduce a signal. To represent cross-talk between ligands and receptors, signaling pathways in GO are starting to be named after the receptor and/or the signal. GO:0038084 is for annotation of any pathway in which the ligand VEGF binds and activates any cell surface receptor (VEGFR, PDGFR etc.). For annotation of signaling pathways where a VEGFR binds one of its physiological ligands (VEGF or an alternative growth factor), consider 'vascular endothelial growth factor receptor signaling pathway ; GO:0048010'.
synonym: "vascular endothelial growth factor signalling pathway" EXACT [GOC:bf]
synonym: "VEGF signaling" EXACT [GOC:bf]
synonym: "VEGF-activated signaling pathway" EXACT [GOC:bf]
is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway
relationship: part_of GO:0035924 ! cellular response to vascular endothelial growth factor stimulus
created_by: rfoulger
creation_date: 2012-02-01T02:27:32Z

[Term]
id: GO:0038085
name: vascular endothelial growth factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a vascular endothelial growth factor." [PMID:17470632, PR:000003096, PR:000007520, PR:000017284, PR:000017285]
synonym: "VEGF binding" EXACT [GOC:bf]
is_a: GO:0019838 ! growth factor binding
created_by: rfoulger
creation_date: 2012-02-01T02:36:36Z

[Term]
id: GO:0038086
name: VEGF-activated platelet-derived growth factor receptor signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a platelet-derived growth factor receptor (PDGFR) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, PMID:17470632]
synonym: "vascular endothelial growth factor-activated platelet-derived growth factor receptor signaling pathway" EXACT [GOC:bf]
synonym: "VEGF-A/PDGFR signaling" NARROW [PMID:17470632]
synonym: "VEGF-activated PDGFR signalling pathway" EXACT [GOC:bf]
synonym: "VEGF-activated platelet-derived growth factor receptor signalling pathway" EXACT [GOC:bf]
synonym: "VEGF/PDGFR signaling pathway" EXACT [PMID:17470632]
is_a: GO:0038084 ! vascular endothelial growth factor signaling pathway
is_a: GO:0048008 ! platelet-derived growth factor receptor signaling pathway
relationship: has_part GO:0005021 ! vascular endothelial growth factor-activated receptor activity
created_by: rfoulger
creation_date: 2012-02-01T03:05:43Z

[Term]
id: GO:0038087
name: VEGF-activated platelet-derived growth factor receptor-alpha signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to an alpha-type platelet-derived growth factor receptor (PDGFR) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, PMID:17470632]
synonym: "vascular endothelial growth factor-activated platelet-derived growth factor receptor-alpha signaling pathway" EXACT [GOC:bf]
synonym: "VEGF-A/PDGFRalpha signaling" NARROW [PMID:17470632]
synonym: "VEGF-activated PDGFRalpha signalling pathway" EXACT [GOC:bf]
synonym: "VEGF-activated platelet-derived growth factor receptor-alpha signalling pathway" EXACT [GOC:bf]
synonym: "VEGF/PDGFRalpha signaling pathway" EXACT [PMID:17470632]
is_a: GO:0035790 ! platelet-derived growth factor receptor-alpha signaling pathway
is_a: GO:0038086 ! VEGF-activated platelet-derived growth factor receptor signaling pathway
created_by: rfoulger
creation_date: 2012-02-01T03:08:13Z

[Term]
id: GO:0038088
name: VEGF-activated platelet-derived growth factor receptor-beta signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a beta-type platelet-derived growth factor receptor (PDGFR) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, PMID:17470632]
synonym: "vascular endothelial growth factor-activated platelet-derived growth factor receptor-beta signaling pathway" EXACT [GOC:bf]
synonym: "VEGF-A/PDGFRbeta signaling" NARROW [PMID:17470632]
synonym: "VEGF-activated PDGFRbeta signalling pathway" EXACT [GOC:bf]
synonym: "VEGF-activated platelet-derived growth factor receptor-beta signalling pathway" EXACT [GOC:bf]
synonym: "VEGF/PDGFRbeta signaling pathway" EXACT [PMID:17470632]
is_a: GO:0035791 ! platelet-derived growth factor receptor-beta signaling pathway
is_a: GO:0038086 ! VEGF-activated platelet-derived growth factor receptor signaling pathway
created_by: rfoulger
creation_date: 2012-02-01T03:10:16Z

[Term]
id: GO:0038089
name: positive regulation of cell migration by vascular endothelial growth factor signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a receptor on the surface of a cell, which activates or increases the frequency, rate or extent of the orderly movement of a cell from one site to another." [GOC:bf, GOC:signaling, PR:000003096, PR:000017284, PR:000017285]
synonym: "positive regulation of cell migration by vascular endothelial growth factor signalling pathway" EXACT [GOC:mah]
synonym: "positive regulation of cell migration by VEGF signaling pathway" EXACT [GOC:bf]
synonym: "VEGF-A-induced cell migration" NARROW [PMID:17470632]
synonym: "VEGF-induced cell migration" EXACT [GOC:bf]
is_a: GO:0030335 ! positive regulation of cell migration
is_a: GO:0038084 ! vascular endothelial growth factor signaling pathway
intersection_of: GO:0038084 ! vascular endothelial growth factor signaling pathway
intersection_of: positively_regulates GO:0016477 ! cell migration
relationship: positively_regulates GO:0016477 ! cell migration
created_by: rfoulger
creation_date: 2012-02-02T03:40:13Z

[Term]
id: GO:0038090
name: positive regulation of cell migration by VEGF-activated platelet derived growth factor receptor signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a platelet-derived growth factor receptor (PDGFR) on the surface of a cell, which activates or increases the frequency, rate or extent of the orderly movement of a cell from one site to another." [GOC:bf, GOC:signaling, PMID:17470632]
synonym: "positive regulation of cell migration by VEGF-activated platelet derived growth factor receptor signalling pathway" EXACT [GOC:mah]
synonym: "positive regulation of cell migration by VEGF/PDGFR signaling pathway" EXACT [PMID:17470632]
synonym: "VEGF/PDGFR-induced cell migration" EXACT [PMID:17470632]
is_a: GO:0038086 ! VEGF-activated platelet-derived growth factor receptor signaling pathway
is_a: GO:0038089 ! positive regulation of cell migration by vascular endothelial growth factor signaling pathway
intersection_of: GO:0038086 ! VEGF-activated platelet-derived growth factor receptor signaling pathway
intersection_of: positively_regulates GO:0016477 ! cell migration
relationship: positively_regulates GO:0016477 ! cell migration
created_by: rfoulger
creation_date: 2012-02-02T03:41:23Z

[Term]
id: GO:0038091
name: positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a platelet-derived growth factor receptor (PDGFR) on the surface of a cell, which activates or increases the frequency, rate or extent of cell proliferation." [GOC:signaling, PMID:17470632]
synonym: "positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signalling pathway" EXACT [GOC:mah]
synonym: "positive regulation of cell proliferation by VEGF/PDGFR signaling pathway" EXACT [GOC:bf]
synonym: "VEGF-A-induced cell proliferation" NARROW [PMID:17470632]
is_a: GO:0008284 ! positive regulation of cell proliferation
is_a: GO:0038086 ! VEGF-activated platelet-derived growth factor receptor signaling pathway
intersection_of: GO:0038086 ! VEGF-activated platelet-derived growth factor receptor signaling pathway
intersection_of: positively_regulates GO:0008283 ! cell proliferation
relationship: positively_regulates GO:0008283 ! cell proliferation
created_by: rfoulger
creation_date: 2012-02-02T03:45:49Z

[Term]
id: GO:0038092
name: nodal signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of a nodal protein to an activin receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:vk, PMID:17287255]
synonym: "nodal signaling" EXACT [GOC:bf]
synonym: "nodal signalling pathway" EXACT [GOC:mah]
is_a: GO:0032924 ! activin receptor signaling pathway
created_by: rfoulger
creation_date: 2012-02-16T02:44:02Z

[Term]
id: GO:0038093
name: Fc receptor signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of the Fc portion of an immunoglobulin to an Fc receptor on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region." [GOC:phg, Wikipedia:Fc_receptor]
synonym: "Fc receptor signalling pathway" EXACT [GOC:bf]
is_a: GO:0002768 ! immune response-regulating cell surface receptor signaling pathway
created_by: rfoulger
creation_date: 2012-02-16T05:11:30Z

[Term]
id: GO:0038094
name: Fc-gamma receptor signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of the Fc portion of immunoglobulin G (IgG) to an Fc-gamma receptor on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region." [GOC:phg, PMID:11244038]
synonym: "Fc-gamma receptor signalling pathway" EXACT [GOC:bf]
is_a: GO:0038093 ! Fc receptor signaling pathway
created_by: rfoulger
creation_date: 2012-02-16T05:22:46Z

[Term]
id: GO:0038095
name: Fc-epsilon receptor signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of the Fc portion of immunoglobulin E (IgE) to an Fc-epsilon receptor on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region." [GOC:phg, PMID:12413516, PMID:15048725]
synonym: "Fc-epsilon receptor signalling pathway" EXACT [GOC:bf]
is_a: GO:0038093 ! Fc receptor signaling pathway
created_by: rfoulger
creation_date: 2012-02-16T05:23:51Z

[Term]
id: GO:0038096
name: Fc-gamma receptor signaling pathway involved in phagocytosis
namespace: biological_process
def: "An Fc-gamma receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes." [GOC:phg, PMID:12488490, PMID:15466916]
synonym: "Fc gamma receptor-dependent phagocytosis" EXACT [PMID:18832707]
synonym: "Fc-gamma receptor signalling pathway involved in phagocytosis" EXACT [GOC:bf]
synonym: "Fcgamma receptor-mediated phagocytosis" EXACT [PMID:15466916]
synonym: "IgG-mediated phagocytosis" EXACT [PMID:1248849]
is_a: GO:0002431 ! Fc receptor mediated stimulatory signaling pathway
is_a: GO:0002433 ! immune response-regulating cell surface receptor signaling pathway involved in phagocytosis
is_a: GO:0038094 ! Fc-gamma receptor signaling pathway
intersection_of: GO:0038094 ! Fc-gamma receptor signaling pathway
intersection_of: part_of GO:0006909 ! phagocytosis
relationship: part_of GO:0006909 ! phagocytosis
created_by: rfoulger
creation_date: 2012-02-16T05:26:25Z

[Term]
id: GO:0038097
name: positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway
namespace: biological_process
def: "An Fc-epsilon receptor signaling pathway that results in the change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors." [GOC:phg, PMID:12413516]
synonym: "Fc epsilon RI-dependent mast cell activation" EXACT [PMID:18377769]
synonym: "Fc epsilon RI-mediated mast cell activation" EXACT [PMID:17336609]
synonym: "positive regulation of mast cell activation by Fc-epsilon receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0002431 ! Fc receptor mediated stimulatory signaling pathway
is_a: GO:0033005 ! positive regulation of mast cell activation
is_a: GO:0038095 ! Fc-epsilon receptor signaling pathway
intersection_of: GO:0038095 ! Fc-epsilon receptor signaling pathway
intersection_of: positively_regulates GO:0045576 ! mast cell activation
relationship: positively_regulates GO:0045576 ! mast cell activation
created_by: rfoulger
creation_date: 2012-02-16T05:30:09Z

[Term]
id: GO:0038098
name: sequestering of BMP from receptor via BMP binding
namespace: biological_process
def: "Binding to a bone morphogenetic protein (BMP) in the extracellular region, and inhibiting BMP signaling by preventing BMP from binding to its cell surface receptor." [GOC:bf, GOC:signaling, PMID:19855014]
synonym: "extracellular sequestering of BMP" BROAD [GOC:bf]
synonym: "extracellular sequestering of bone morphogenetic protein" BROAD [GOC:bf]
is_a: GO:0030514 ! negative regulation of BMP signaling pathway
is_a: GO:0035581 ! sequestering of extracellular ligand from receptor
created_by: rfoulger
creation_date: 2012-02-22T11:28:54Z

[Term]
id: GO:0038099
name: nodal receptor complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a complex containing a type II activin receptor, a type I activin receptor, and a coreceptor of the EGF-CFC family (e.g. Cripto or Cryptic, in mammals)." [GOC:bf, GOC:signaling, PMID:15062104]
synonym: "ActRIIB.ALK4.EGF-CFC complex formation" EXACT [GOC:bf]
synonym: "nodal receptor complex formation" EXACT [GOC:bf]
is_a: GO:0043623 ! cellular protein complex assembly
relationship: part_of GO:0038092 ! nodal signaling pathway
created_by: rfoulger
creation_date: 2012-02-17T11:16:40Z

[Term]
id: GO:0038100
name: nodal binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a nodal protein, a member of the transforming growth factor-beta superfamily." [GOC:bf, PMID:20629020, PR:000000105]
is_a: GO:0005515 ! protein binding
created_by: rfoulger
creation_date: 2012-02-17T11:19:08Z

[Term]
id: GO:0038101
name: sequestering of nodal from receptor via nodal binding
namespace: biological_process
def: "Binding to a nodal protein in the extracellular region, and inhibiting nodal signaling by preventing nodal from binding to its cell surface receptor." [GOC:signaling, PMID:14570583, PMID:15062104]
synonym: "binding to and sequestering nodal" EXACT [GOC:bf]
synonym: "extracellular regulation of nodal" BROAD [GOC:bf]
synonym: "nodal antagonist activity" BROAD [PMID:14570583]
is_a: GO:0035581 ! sequestering of extracellular ligand from receptor
relationship: has_part GO:0038100 ! nodal binding
relationship: part_of GO:1900108 ! negative regulation of nodal signaling pathway
created_by: rfoulger
creation_date: 2012-02-17T11:21:22Z

[Term]
id: GO:0038102
name: activin receptor antagonist activity
namespace: molecular_function
def: "Interacting with an activin receptor complex to reduce the action of another ligand, the agonist. A receptor antagonist does not initiate signaling upon binding to a receptor, but instead blocks an agonist from binding to the receptor." [GOC:signaling, PMID:15062104]
comment: This term refers to inhibition of a member of the activin receptor family; activin receptors bind to multiple ligands including activin and nodal.
is_a: GO:0048019 ! receptor antagonist activity
relationship: part_of GO:0032926 ! negative regulation of activin receptor signaling pathway
created_by: rfoulger
creation_date: 2012-02-17T11:28:59Z

[Term]
id: GO:0038103
name: activin receptor antagonist activity involved in negative regulation of nodal signaling pathway
namespace: molecular_function
def: "Interacting with an activin receptor to reduce the action of the agonist nodal. A receptor antagonist does not initiate signaling upon binding to a receptor, but instead blocks an agonist from binding to the receptor." [GOC:signaling, PMID:15062104]
synonym: "activin receptor antagonist activity involved in negative regulation of nodal signalling pathway" EXACT [GOC:mah]
synonym: "nodal antagonist activity" EXACT [GOC:bf]
is_a: GO:0038102 ! activin receptor antagonist activity
intersection_of: GO:0038102 ! activin receptor antagonist activity
intersection_of: part_of GO:1900108 ! negative regulation of nodal signaling pathway
relationship: part_of GO:1900108 ! negative regulation of nodal signaling pathway
created_by: rfoulger
creation_date: 2012-02-17T11:30:21Z

[Term]
id: GO:0038104
name: nodal receptor complex
namespace: cellular_component
def: "A protein complex containing at least a type II activin receptor, a type I activin receptor, and a coreceptor (EGF-CFC protein) such as Cripto or Cryptic. Nodal receptor complexes are capable of binding a nodal protein and transducing the signal into the cell." [GOC:bf, GOC:signaling, PMID:11024047, PMID:15062104]
comment: Nodal signals through activin receptors but (unlike activin) also requires EGF-CFC coreceptors (such as Cripto or Cryptic in mammals) to signal. This term is intended for receptor/co-receptor components and not a nodal-receptor complex.
synonym: "ActRIIB.ALK4.EGF-CFC complex" NARROW [GOC:bf]
is_a: GO:0043235 ! receptor complex
created_by: rfoulger
creation_date: 2012-02-17T11:12:21Z

[Term]
id: GO:0038105
name: sequestering of TGFbeta from receptor via TGFbeta binding
namespace: biological_process
def: "Binding to a transforming growth factor-beta (TGFbeta) protein in the extracellular region, and inhibiting TGFbeta signaling by preventing TGFbeta from binding to its cell surface receptor." [GOC:bf, GOC:signaling, PMID:19855014]
comment: This term is for annotation of gene products that bind to TGFbeta. For gene products that tether the TGFbeta-containing latency complex to the extracellular matrix, but do not necessarily bind TGF-beta directly, consider instead annotating to 'sequestering of TGFbeta in extracellular matrix ; GO:0035583'.
synonym: "extracellular sequestering of TGFbeta" BROAD [GOC:bf]
synonym: "extracellular sequestering of transforming growth factor-beta" BROAD [GOC:bf]
is_a: GO:0035581 ! sequestering of extracellular ligand from receptor
created_by: rfoulger
creation_date: 2012-02-22T11:35:58Z

[Term]
id: GO:0038106
name: choriogonadotropin hormone binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with choriogonadotropin hormone, a heterodimer, with an alpha subunit identical to that of luteinizing hormone (LH), follicle-stimulating hormone (FSH) and thyroid-stimulating hormone (TSH), and a unique beta subunit." [GOC:BHF, GOC:rl, Wikipedia:Human_chorionic_gonadotropin]
synonym: "chorionic gonadotrophin binding" EXACT [Wikilpedia:Human_chorionic_gonadotropin]
synonym: "chorionic gonadotropin binding" EXACT [Wikipedia:Human_chorionic_gonadotropin]
is_a: GO:0042562 ! hormone binding
created_by: rfoulger
creation_date: 2012-03-08T03:58:40Z

[Term]
id: GO:0038107
name: nodal signaling pathway involved in determination of left/right asymmetry
namespace: biological_process
def: "A series of molecular signals initiated by the binding of a nodal protein to an activin receptor on the surface of a target cell, which contributes to the establishment of an organism's body plan or part of an organism with respect to the left and right halves." [GOC:BHF, GOC:vk, PMID:12857784, PMID:17287255, PMID:20413706]
synonym: "nodal signalling pathway involved in determination of left/right asymmetry" EXACT [GOC:mah]
synonym: "regulation of transcription from RNA polymerase II promoter by nodal signaling pathway, involved in determination of left/right symmetry" EXACT [GOC:bf]
is_a: GO:0038092 ! nodal signaling pathway
is_a: GO:1900094 ! regulation of transcription from RNA polymerase II promoter involved in determination of left/right symmetry
intersection_of: GO:0038092 ! nodal signaling pathway
intersection_of: part_of GO:0007368 ! determination of left/right symmetry
relationship: part_of GO:0007368 ! determination of left/right symmetry
created_by: rfoulger
creation_date: 2012-02-29T10:18:59Z

[Term]
id: GO:0038108
name: negative regulation of appetite by leptin-mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of leptin to a receptor on the surface of a cell, which reduces appetite, the desire or physical craving for food." [GOC:BHF, GOC:vk, PMID:19150989]
synonym: "inhibition of appetite by leptin signaling" EXACT [GOC:bf]
synonym: "negative regulation of appetite by leptin-mediated signalling pathway" EXACT [GOC:mah]
synonym: "reduction of appetite by leptin-mediated signaling" EXACT [GOC:bf]
synonym: "suppression of appetite by leptin-mediated signaling pathway" EXACT [GOC:bf]
is_a: GO:0032099 ! negative regulation of appetite
is_a: GO:0033210 ! leptin-mediated signaling pathway
created_by: rfoulger
creation_date: 2012-03-09T11:14:36Z

[Term]
id: GO:0038109
name: Kit signaling pathway
namespace: biological_process
def: "A series of molecular signals that starts with the binding of stem cell factor to the tyrosine kinase receptor KIT on the surface of a cell, and ends with regulation of a downstream cellular process, e.g. transcription. Stem cell factor (KIT ligand) binding to the receptor Kit mediates receptor dimerization, activation of its intrinsic tyrosine kinase activity and autophosphorylation. The activated receptor then phosphorylates various substrates, thereby activating distinct signaling cascades within the cell that trigger a change in state or activity of the cell." [GOC:nhn, GOC:signaling, PMID:16129412]
synonym: "Kit signalling pathway" EXACT [GOC:mah]
synonym: "SCF signaling pathway" EXACT [PMID:18787413]
synonym: "stem cell factor receptor signaling pathway" EXACT [PMID:16129412]
synonym: "stem cell factor signaling pathway" EXACT [PMID:16129412]
is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway
is_a: GO:0019221 ! cytokine-mediated signaling pathway
relationship: part_of GO:0036216 ! cellular response to stem cell factor stimulus
created_by: rfoulger
creation_date: 2012-03-22T10:09:48Z

[Term]
id: GO:0038110
name: interleukin-2-mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of interleukin-2 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling]
synonym: "IL-2-mediated signaling pathway" EXACT [GOC:bf]
synonym: "interleukin-2-mediated signalling pathway" EXACT [GOC:bf]
is_a: GO:0019221 ! cytokine-mediated signaling pathway
relationship: part_of GO:0071352 ! cellular response to interleukin-2
created_by: rfoulger
creation_date: 2012-03-22T10:18:29Z

[Term]
id: GO:0038111
name: interleukin-7-mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of interleukin-7 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling]
synonym: "IL-7-mediated signaling pathway" EXACT [GOC:bf]
synonym: "interleukin-7-mediated signalling pathway" EXACT [GOC:bf]
is_a: GO:0019221 ! cytokine-mediated signaling pathway
relationship: part_of GO:0098761 ! cellular response to interleukin-7
created_by: rfoulger
creation_date: 2012-03-22T10:19:27Z

[Term]
id: GO:0038112
name: interleukin-8-mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of interleukin-8 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling]
synonym: "IL-8-mediated signaling pathway" EXACT [GOC:bf]
synonym: "interleukin-8-mediated signalling pathway" EXACT [GOC:bf]
is_a: GO:0019221 ! cytokine-mediated signaling pathway
relationship: part_of GO:0098759 ! cellular response to interleukin-8
created_by: rfoulger
creation_date: 2012-03-22T10:19:59Z

[Term]
id: GO:0038113
name: interleukin-9-mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of interleukin-9 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling]
synonym: "IL-9-mediated signaling pathway" EXACT [GOC:bf]
synonym: "interleukin-9-mediated signalling pathway" EXACT [GOC:bf]
is_a: GO:0019221 ! cytokine-mediated signaling pathway
relationship: part_of GO:0071355 ! cellular response to interleukin-9
created_by: rfoulger
creation_date: 2012-03-22T10:20:33Z

[Term]
id: GO:0038114
name: interleukin-21-mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of interleukin-21 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling]
synonym: "IL-21-mediated signaling pathway" EXACT [GOC:bf]
synonym: "interleukin-21-mediated signalling pathway" EXACT [GOC:bf]
is_a: GO:0019221 ! cytokine-mediated signaling pathway
relationship: part_of GO:0098757 ! cellular response to interleukin-21
created_by: rfoulger
creation_date: 2012-03-22T10:21:01Z

[Term]
id: GO:0038115
name: chemokine (C-C motif) ligand 19 signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of the C-C chemokine CCL19 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:15059845, PR:000001991]
comment: The C-C chemokine CCL19 s a known agonist of the chemokine receptor type 7 (CCR7). Consider instead annotating to the child term 'CCL19-activated CCR7 signaling pathway ; GO:0038119'.
synonym: "C-C chemokine receptor type 7 signaling pathway" RELATED [PMID:15059845, PR:000001203]
synonym: "CCL19-mediated signaling pathway" EXACT [PMID:15059845]
synonym: "chemokine (C-C motif) ligand 19 signalling pathway" EXACT [GOC:mah]
is_a: GO:0070098 ! chemokine-mediated signaling pathway
created_by: rfoulger
creation_date: 2012-03-22T11:28:32Z

[Term]
id: GO:0038116
name: chemokine (C-C motif) ligand 21 signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of the C-C chemokine CCL21 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:15059845, PR:000001993]
comment: The C-C chemokine CCL21 s a known agonist of the chemokine receptor type 7 (CCR7). Consider instead annotating to the child term 'CCL21-activated CCR7 signaling pathway ; GO:0038120'.
synonym: "C-C chemokine receptor type 7 signaling pathway" RELATED [PMID:15059845, PR:000001203]
synonym: "CCL21-mediated signaling pathway" EXACT [PMID:15059845]
synonym: "chemokine (C-C motif) ligand 21 signalling pathway" EXACT [GOC:mah]
is_a: GO:0070098 ! chemokine-mediated signaling pathway
created_by: rfoulger
creation_date: 2012-03-22T11:30:47Z

[Term]
id: GO:0038117
name: C-C motif chemokine 19 receptor activity
namespace: molecular_function
def: "Combining with the C-C motif chemokine 19 (CCL19) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:signaling, PMID:15059845, PR:000001991]
synonym: "CCL19 receptor activity" RELATED [PMID:15059845]
is_a: GO:0016493 ! C-C chemokine receptor activity
relationship: has_part GO:0035757 ! chemokine (C-C motif) ligand 19 binding
relationship: part_of GO:0038115 ! chemokine (C-C motif) ligand 19 signaling pathway
created_by: rfoulger
creation_date: 2012-03-22T11:59:10Z

[Term]
id: GO:0038118
name: C-C chemokine receptor CCR7 signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by a the C-C chemokine type 7 receptor on the surface of a cell binding to one of it's physiological ligands, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, PMID:15059845, PMID:15778365, PR:000001203]
comment: This term was created to show the binding of cytokines to multiple receptor types, and vice-versa. Known agonists of chemokine receptor type 7 (CCR7) are C-C chemokines CCL19 and CCL21. Consider instead annotating to one of the child terms 'CCL19-activated CCR7 signaling pathway ; GO:0038119' and/or 'CCL21-activated CCR7 signaling pathway ; GO:0038120'.
synonym: "C-C chemokine receptor CCR7 signalling pathway" EXACT [GOC:mah]
synonym: "CCR7 signaling pathway" RELATED [PR:000001203]
is_a: GO:0070098 ! chemokine-mediated signaling pathway
created_by: rfoulger
creation_date: 2012-03-22T11:43:57Z

[Term]
id: GO:0038119
name: CCL19-activated CCR7 signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of the C-C chemokine CCL19 to a C-C chemokine type 7 receptor (CCR7) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:15059845, PR:000001203]
synonym: "CCL19-activated CCR7 signalling pathway" EXACT [GOC:mah]
is_a: GO:0038115 ! chemokine (C-C motif) ligand 19 signaling pathway
is_a: GO:0038118 ! C-C chemokine receptor CCR7 signaling pathway
created_by: rfoulger
creation_date: 2012-03-22T11:47:24Z

[Term]
id: GO:0038120
name: CCL21-activated CCR7 signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of the C-C chemokine CCL21 to a C-C chemokine type 7 receptor (CCR7) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:15059845, PR:000001203]
synonym: "CCL21-activated CCR7 signalling pathway" EXACT [GOC:mah]
is_a: GO:0038116 ! chemokine (C-C motif) ligand 21 signaling pathway
is_a: GO:0038118 ! C-C chemokine receptor CCR7 signaling pathway
created_by: rfoulger
creation_date: 2012-03-22T11:47:24Z

[Term]
id: GO:0038121
name: C-C motif chemokine 21 receptor activity
namespace: molecular_function
def: "Combining with the C-C motif chemokine 21 (CCL21) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:signaling, PMID:15059845, PR:000001993]
synonym: "CCL21 receptor activity" RELATED [PMID:15059845, PR:000001993]
is_a: GO:0016493 ! C-C chemokine receptor activity
relationship: has_part GO:0035758 ! chemokine (C-C motif) ligand 21 binding
relationship: part_of GO:0038116 ! chemokine (C-C motif) ligand 21 signaling pathway
created_by: rfoulger
creation_date: 2012-03-22T01:28:06Z

[Term]
id: GO:0038122
name: C-C motif chemokine 5 receptor activity
namespace: molecular_function
def: "Combining with the C-C motif chemokine 5 (CCL5) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:signaling, PR:000002094]
synonym: "CCL5 receptor activity" EXACT [PR:000002094]
synonym: "RANTES receptor activity" EXACT [GOC:bf]
synonym: "small inducible cytokine A5 receptor activity" EXACT [PR:000002094]
is_a: GO:0016493 ! C-C chemokine receptor activity
relationship: has_part GO:0071791 ! chemokine (C-C motif) ligand 5 binding
relationship: part_of GO:0035689 ! chemokine (C-C motif) ligand 5 signaling pathway
created_by: rfoulger
creation_date: 2012-03-22T01:36:00Z

[Term]
id: GO:0038123
name: toll-like receptor TLR1:TLR2 signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of a heterodimeric TLR1:TLR2 complex to one of it's physiological ligands, followed by transmission of the signal by the activated receptor, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:17318230]
synonym: "TLR2:TLR1 signaling pathway" EXACT [GOC:bf]
synonym: "toll-like receptor TLR1:TLR2 signalling pathway" EXACT [GOC:mah]
is_a: GO:0002224 ! toll-like receptor signaling pathway
created_by: rfoulger
creation_date: 2012-03-23T10:20:13Z

[Term]
id: GO:0038124
name: toll-like receptor TLR6:TLR2 signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of a heterodimeric TLR6:TLR2 complex to one of it's physiological ligands, followed by transmission of the signal by the activated receptor, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:17318230]
synonym: "TLR2:TLR6 signaling pathway" EXACT [GOC:bf]
synonym: "toll-like receptor TLR6:TLR2 signalling pathway" EXACT [GOC:mah]
xref: Reactome:REACT_100025 "Toll Like Receptor TLR6:TLR2 Cascade, Danio rerio"
xref: Reactome:REACT_103395 "Toll Like Receptor TLR6:TLR2 Cascade, Arabidopsis thaliana"
xref: Reactome:REACT_106218 "Toll Like Receptor TLR6:TLR2 Cascade, Drosophila melanogaster"
xref: Reactome:REACT_106314 "Toll Like Receptor TLR6:TLR2 Cascade, Saccharomyces cerevisiae"
xref: Reactome:REACT_30573 "Toll Like Receptor TLR6:TLR2 Cascade, Dictyostelium discoideum"
xref: Reactome:REACT_78328 "Toll Like Receptor TLR6:TLR2 Cascade, Bos taurus"
xref: Reactome:REACT_79076 "Toll Like Receptor TLR6:TLR2 Cascade, Oryza sativa"
xref: Reactome:REACT_8006 "Toll Like Receptor TLR6:TLR2 Cascade, Homo sapiens"
xref: Reactome:REACT_81073 "Toll Like Receptor TLR6:TLR2 Cascade, Canis familiaris"
xref: Reactome:REACT_82484 "Toll Like Receptor TLR6:TLR2 Cascade, Taeniopygia guttata"
xref: Reactome:REACT_82627 "Toll Like Receptor TLR6:TLR2 Cascade, Xenopus tropicalis"
xref: Reactome:REACT_88205 "Toll Like Receptor TLR6:TLR2 Cascade, Caenorhabditis elegans"
xref: Reactome:REACT_88998 "Toll Like Receptor TLR6:TLR2 Cascade, Gallus gallus"
xref: Reactome:REACT_92983 "Toll Like Receptor TLR6:TLR2 Cascade, Mus musculus"
xref: Reactome:REACT_95481 "Toll Like Receptor TLR6:TLR2 Cascade, Rattus norvegicus"
xref: Reactome:REACT_97377 "Toll Like Receptor TLR6:TLR2 Cascade, Schizosaccharomyces pombe"
xref: Reactome:REACT_98726 "Toll Like Receptor TLR6:TLR2 Cascade, Sus scrofa"
is_a: GO:0002224 ! toll-like receptor signaling pathway
created_by: rfoulger
creation_date: 2012-03-23T10:29:09Z

[Term]
id: GO:0038127
name: ERBB signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptor tyrosine kinases on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:jc, PMID:16460914, PR:000001812, Wikipedia:ErbB]
synonym: "EGF receptor family signaling pathway" EXACT [PMID:11597398]
synonym: "EGFR family signaling pathway" RELATED [PMID:11597398]
synonym: "ErbB signaling" EXACT [PMID:20933094, Wikipedia:ErbB]
synonym: "ERBB signalling pathway" EXACT [GOC:mah]
is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway
created_by: rfoulger
creation_date: 2012-03-30T09:23:01Z

[Term]
id: GO:0038128
name: ERBB2 signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptors on the surface of a cell, where the signal is transmitted by ERBB2. The pathway ends with regulation of a downstream cellular process, e.g. transcription. ERBB2 receptors are themselves unable to bind to ligands, but act as a signal-amplifying tyrosine kinase within a heterodimeric pair." [GOC:jc, PMID:16460914, PR:000002082, Reactome:REACT_115755.1]
synonym: "ERBB2 signalling pathway" EXACT [GOC:mah]
synonym: "HER2 signaling pathway" EXACT [PR:000002082]
synonym: "NEU signaling" EXACT [Reactome:REACT_115755.1]
synonym: "receptor tyrosine-protein kinase erbB-2 signaling pathway" EXACT [PR:000002082]
xref: Reactome:REACT_115755.1 "Signaling by ERBB2, Homo sapiens"
is_a: GO:0038127 ! ERBB signaling pathway
created_by: rfoulger
creation_date: 2012-03-30T10:05:12Z

[Term]
id: GO:0038129
name: ERBB3 signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB3 on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription. ERBB3 receptors have impaired kinase activity and rely on the kinase activity of the heterodimer partner for activation and signal transmission." [GOC:jc, PMID:16460914, PR:000007159, Reactome:REACT_115637.1]
synonym: "ERBB3 signalling pathway" EXACT [GOC:mah]
synonym: "HER3 signaling pathway" EXACT [PR:000007159]
synonym: "receptor tyrosine-protein kinase erbB-3 signaling pathway" EXACT [PR:000007159]
xref: Reactome:REACT_115637.1 "ERBB3 binds neuregulins, Homo sapiens"
is_a: GO:0038127 ! ERBB signaling pathway
created_by: rfoulger
creation_date: 2012-03-30T10:42:28Z

[Term]
id: GO:0038130
name: ERBB4 signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB4 on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:jc, PMID:16460914, PR:000007160, Reactome:REACT_115596.2]
synonym: "ERBB4 signalling pathway" EXACT [GOC:mah]
synonym: "HER4 signaling pathway" EXACT [PR:000007160]
synonym: "receptor tyrosine-protein kinase erbB-4 signaling pathway" EXACT [PR:000007160]
xref: Reactome:REACT_115596.2 "Signaling by ERBB4, Homo sapiens"
is_a: GO:0038127 ! ERBB signaling pathway
created_by: rfoulger
creation_date: 2012-03-30T10:44:08Z

[Term]
id: GO:0038131
name: neuregulin receptor activity
namespace: molecular_function
def: "Combining with a neuregulin, a member of the EGF family of growth factors, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, GOC:signaling, PMID:16460914, PMID:20672328]
comment: Consider also annotating to 'ERBB3 signaling pathway ; GO:0038129' and/or 'ERBB4 signaling pathway ; GO:0038130'.
synonym: "NRG receptor activity" EXACT [PMID:16460914]
synonym: "NRG1 receptor activity" NARROW [PMID:16460914]
synonym: "NRG2 receptor activity" NARROW [PMID:16460914]
is_a: GO:0004888 ! transmembrane signaling receptor activity
relationship: has_part GO:0038132 ! neuregulin binding
created_by: rfoulger
creation_date: 2012-03-30T10:47:11Z

[Term]
id: GO:0038132
name: neuregulin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a neuregulin, a member of the EGF family of growth factors." [GOC:bf, GOC:signaling]
is_a: GO:0019838 ! growth factor binding
created_by: rfoulger
creation_date: 2012-03-30T10:59:56Z

[Term]
id: GO:0038133
name: ERBB2-ERBB3 signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by binding of a ligand to a ERBB3 receptor on the surface of a cell, followed by transmission of the signal by a heterodimeric complex of ERBB2 and ERBB3. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB3. ERBB3 also has impaired kinase activity and relies on ERBB2 for activation and signal transmission." [GOC:signaling, PMID:16460914, Reactome:REACT_115761.1]
synonym: "ERBB2-ERBB3 signalling pathway" EXACT [GOC:mah]
synonym: "HER2-HER3 signaling pathway" EXACT [PR:000002082, PR:000007159]
is_a: GO:0038128 ! ERBB2 signaling pathway
is_a: GO:0038129 ! ERBB3 signaling pathway
created_by: rfoulger
creation_date: 2012-03-30T11:10:44Z

[Term]
id: GO:0038134
name: ERBB2-EGFR signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by binding of a ligand to an epidermal growth factor receptor (EGFR/ERBB1) on the surface of a cell, followed by transmission of the signal by a heterodimeric complex of ERBB2 and EGFR. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as EGFR." [GOC:signaling, PMID:16460914, Reactome:REACT_115761.1]
synonym: "EGFR-HER2 signaling pathway" EXACT [PR:000002082, PR:000006933]
synonym: "ERBB2-EGFR signalling pathway" EXACT [GOC:mah]
is_a: GO:0007173 ! epidermal growth factor receptor signaling pathway
is_a: GO:0038128 ! ERBB2 signaling pathway
created_by: rfoulger
creation_date: 2012-03-30T11:16:28Z

[Term]
id: GO:0038135
name: ERBB2-ERBB4 signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by binding of a ligand to a ERBB4 receptor on the surface of a cell, followed by transmission of the signal by a heterodimeric complex of ERBB2 and ERBB4. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB4." [GOC:signaling, PMID:16460914, Reactome:REACT_115761.1]
synonym: "ERBB2-ERBB4 signalling pathway" EXACT [GOC:mah]
synonym: "HER2-HER4 signaling pathway" EXACT [PR:000002082, PR:000007160]
is_a: GO:0038128 ! ERBB2 signaling pathway
is_a: GO:0038130 ! ERBB4 signaling pathway
created_by: rfoulger
creation_date: 2012-03-30T11:19:52Z

[Term]
id: GO:0038136
name: ERBB3-ERBB4 signaling pathway
namespace: biological_process
def: "A series of molecular signals transmitted by a heterodimeric complex of the tyrosine kinase receptors ERBB3 and ERBB4. The pathway begins with binding of a ligand to either cell surface receptor, or the dimeric receptor complex, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, PMID:16460914, Reactome:REACT_115947.1]
synonym: "ERBB3-ERBB4 signalling pathway" EXACT [GOC:mah]
synonym: "HER3-HER4 signaling pathway" EXACT [PR:000007159, PR:000007160]
is_a: GO:0038129 ! ERBB3 signaling pathway
is_a: GO:0038130 ! ERBB4 signaling pathway
created_by: rfoulger
creation_date: 2012-03-30T11:21:19Z

[Term]
id: GO:0038137
name: ERBB4-EGFR signaling pathway
namespace: biological_process
def: "A series of molecular signals transmitted by a heterodimeric complex of the tyrosine kinase receptors EGFR (epidermal growth factor receptor/ERBB1) and ERBB4. The pathway begins with binding of a ligand to either cell surface receptor, or the dimeric receptor complex, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, PMID:16460914, Reactome:REACT_116135.1]
synonym: "ERBB1-ERBB4 signaling pathway" EXACT [PR:000006933, PR:000007160]
synonym: "ERBB4-EGFR signalling pathway" EXACT [GOC:mah]
synonym: "HER1-HER4 signaling pathway" EXACT [PR:000006933, PR:000007160]
is_a: GO:0007173 ! epidermal growth factor receptor signaling pathway
is_a: GO:0038130 ! ERBB4 signaling pathway
created_by: rfoulger
creation_date: 2012-03-30T11:30:30Z

[Term]
id: GO:0038138
name: ERBB4-ERBB4 signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB4, followed by ligand-induced homodimerization of ERBB4 and transmission of the signal into the cell by the homodimeric ERBB4 complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, PMID:16460914, Reactome:REACT_115969.2]
synonym: "ERBB4 homodimeric signaling pathway" EXACT [PMID:16460914]
synonym: "ERBB4-ERBB4 signalling pathway" EXACT [GOC:mah]
synonym: "HER4-HER4 signaling pathway" EXACT [PR:000007160]
is_a: GO:0038130 ! ERBB4 signaling pathway
created_by: rfoulger
creation_date: 2012-03-30T11:41:05Z

[Term]
id: GO:0038139
name: ERBB4-EGFR complex
namespace: cellular_component
def: "A heterodimeric complex between the tyrosine kinase receptors ERBB4 (also called HER4) and epidermal growth factor receptor (EGFR/ERBB1)." [GOC:signaling, PMID:16460914, Reactome:REACT_116654.1]
synonym: "EGFR-ERBB4 complex" EXACT [GOC:bf]
synonym: "ERBB4:EGFR heterodimer" EXACT [Reactome:REACT_116654.1]
xref: Reactome:REACT_116654.1 "ERBB4:EGFR heterodimer, Homo sapiens"
is_a: GO:0098802 ! plasma membrane receptor complex
created_by: rfoulger
creation_date: 2012-03-30T01:59:41Z

[Term]
id: GO:0038140
name: ERBB4-ERBB3 complex
namespace: cellular_component
def: "A heterodimeric complex between the tyrosine kinase receptors ERBB4 (also called HER4) and ERBB3 (also called HER3). ERBB3 has impaired kinase activity so relies on the kinase activity of its heterodimer partner for activation and signal transmission." [GOC:signaling, PMID:16460914, Reactome:REACT_117805.1]
synonym: "ERBB3-ERBB4 complex" EXACT [GOC:bf]
synonym: "ERBB4:ERBB3 heterodimer" EXACT [Reactome:117805.1]
xref: Reactome:REACT_117805.1 "ERBB4:ERBB3 heterodimer, Homo sapiens"
is_a: GO:0098802 ! plasma membrane receptor complex
created_by: rfoulger
creation_date: 2012-03-30T02:04:16Z

[Term]
id: GO:0038141
name: ERBB4-ERBB4 complex
namespace: cellular_component
def: "A homodimeric complex containing two monomers of the tyrosine kinase receptor ERBB4 (also called HER4)." [GOC:signaling, PMID:16460914, Reactome:REACT_117065.1]
synonym: "ERBB4 homodimer" EXACT [Reactome:REACT_117805.1]
xref: Reactome:REACT_117065.1 "ERBB4 homodimers, Homo sapiens"
is_a: GO:0098802 ! plasma membrane receptor complex
created_by: rfoulger
creation_date: 2012-03-30T02:06:20Z

[Term]
id: GO:0038142
name: EGFR:ERBB2 complex
namespace: cellular_component
def: "A heterodimeric complex between the tyrosine kinase receptor ERBB2 and a ligand-activated epidermal growth factor receptor (EGFR/ERBB1). ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as EGFR." [GOC:signaling, PMID:16460914, PMID:1973074, Reactome:REACT_115761.1, Reactome:REACT_116379.1, Reactome:REACT_117594.1]
synonym: "EGF:EGFR:ERBB2 complex" NARROW [Reactome:REACT_116379.1]
synonym: "EGFR:ERBB2 heterodimer" RELATED [Reactome:REACT_116379.1]
xref: Reactome:REACT_116379.1 "ERBB2 heterodimers"
is_a: GO:0098802 ! plasma membrane receptor complex
created_by: rfoulger
creation_date: 2012-03-30T02:10:38Z

[Term]
id: GO:0038143
name: ERBB3:ERBB2 complex
namespace: cellular_component
def: "A heterodimeric complex between the tyrosine kinase receptor ERBB2 and a ligand-activated receptor ERBB3. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB3." [GOC:signaling, PMID:16460914, PMID:8665853, Reactome:REACT_115761.1, Reactome:REACT_116379.1, Reactome:REACT_117748.1]
synonym: "EGFR:ERBB2 heterodimer" NARROW [Reactome:REACT_116379.1]
synonym: "NRG1/2:ERBB3:ERBB2" NARROW [Reactome:REACT_117748.1]
xref: Reactome:REACT_116379.1 "ERBB2 heterodimers"
is_a: GO:0098802 ! plasma membrane receptor complex
created_by: rfoulger
creation_date: 2012-03-30T02:16:56Z

[Term]
id: GO:0038144
name: ERBB4:ERBB2 complex
namespace: cellular_component
def: "A heterodimeric complex between the tyrosine kinase receptor ERBB2 and a ligand-activated receptor ERBB4. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB4." [GOC:signaling, PMID:16460914, PMID:16978839, Reactome:REACT_115761.1, Reactome:REACT_116375.1, Reactome:REACT_116379.1]
synonym: "ERBB4:ERBB2 heterodimer" NARROW [Reactome:REACT_116375.1]
synonym: "NRGs/EGFLs:ERBB4:ERBB2" NARROW [Reactome:REACT_116375.1]
xref: Reactome:REACT_116379.1 "ERBB2 heterodimers"
is_a: GO:0098802 ! plasma membrane receptor complex
created_by: rfoulger
creation_date: 2012-03-30T02:24:01Z

[Term]
id: GO:0038145
name: macrophage colony-stimulating factor signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of the cytokine macrophage colony-stimulating factor (M-CSF) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, GOC:uh, PMID:12138890, PR:000005930, Wikipedia:Macrophage_colony-stimulating_factor]
synonym: "M-CSF signaling pathway" EXACT [PMID:12138890]
synonym: "macrophage colony-stimulating factor signalling pathway" EXACT [GOC:bf]
is_a: GO:0019221 ! cytokine-mediated signaling pathway
relationship: part_of GO:0036006 ! cellular response to macrophage colony-stimulating factor stimulus
created_by: rfoulger
creation_date: 2012-04-27T11:04:18Z

[Term]
id: GO:0038146
name: chemokine (C-X-C motif) ligand 12 signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of the chemokine CXCL12 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PR:000006066, Wikipedia:Stromal_cell-derived_factor-1]
synonym: "CXCL12 signaling pathway" EXACT [GOC:bf]
synonym: "CXCL12-activated CXCR7 signaling pathway" NARROW [GOC:bf]
synonym: "SDF1 signaling pathway" EXACT [HGNC:10672, PMID:22204316, PR:000006066]
synonym: "stromal cell-derived factor-1 signaling pathway" EXACT [HGNC:10672, PMID:22204316, PR:000006066]
is_a: GO:0070098 ! chemokine-mediated signaling pathway
created_by: rfoulger
creation_date: 2012-05-11T11:26:17Z

[Term]
id: GO:0038147
name: C-X-C motif chemokine 12 receptor activity
namespace: molecular_function
def: "Combining with the C-X-C motif chemokine 12 (CXCL12) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, PMID:22204316]
synonym: "CXCL12 receptor activity" EXACT [GOC:bf]
synonym: "CXCR4" NARROW [PMID:22204316]
synonym: "CXCR7" NARROW [PMID:22204316]
synonym: "SDF-1 receptor activity" RELATED [HGNC:10672, PR:000006066]
synonym: "stromal cell-derived factor-1 receptor activity" EXACT [HGNC:10672, PR:000006066]
is_a: GO:0016494 ! C-X-C chemokine receptor activity
relationship: part_of GO:0038146 ! chemokine (C-X-C motif) ligand 12 signaling pathway
created_by: rfoulger
creation_date: 2012-05-11T11:32:53Z

[Term]
id: GO:0038148
name: chemokine (C-C motif) ligand 2 signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of the C-C chemokine CCL2 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PR:000002122, Wikipedia:CCL2]
synonym: "CCL2 signaling pathway" EXACT [GOC:bf]
is_a: GO:0070098 ! chemokine-mediated signaling pathway
created_by: rfoulger
creation_date: 2012-05-11T11:36:08Z

[Term]
id: GO:0038149
name: C-C motif chemokine 2 receptor activity
namespace: molecular_function
def: "Combining with the C-C motif chemokine 2 (CCL2) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, GOC:signaling]
synonym: "CCL2 receptor activity" EXACT [GOC:bf]
is_a: GO:0016493 ! C-C chemokine receptor activity
relationship: part_of GO:0038148 ! chemokine (C-C motif) ligand 2 signaling pathway
created_by: rfoulger
creation_date: 2012-05-11T11:37:16Z

[Term]
id: GO:0038150
name: C-C chemokine receptor CCR2 signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by a the C-C chemokine type 2 receptor (CCR2) on the surface of a cell binding to one of it's physiological ligands, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PR:000001199]
synonym: "C-C chemokine receptor type 2 signaling pathway" EXACT [PR:000001199]
is_a: GO:0070098 ! chemokine-mediated signaling pathway
created_by: rfoulger
creation_date: 2012-05-11T11:41:02Z

[Term]
id: GO:0038151
name: CCL2-activated CCR2 signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of the C-C chemokine CCL2 to a C-C chemokine type 2 receptor (CCR2) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling]
synonym: "CCL2/CCR2 signaling pathway" EXACT [GOC:bf]
is_a: GO:0038148 ! chemokine (C-C motif) ligand 2 signaling pathway
is_a: GO:0038150 ! C-C chemokine receptor CCR2 signaling pathway
created_by: rfoulger
creation_date: 2012-05-11T11:41:58Z

[Term]
id: GO:0038152
name: C-C chemokine receptor CCR4 signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by a the C-C chemokine type 2 receptor (CCR4) on the surface of a cell binding to one of it's physiological ligands, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PR:000001200]
synonym: "C-C chemokine receptor type 4 signaling pathway" EXACT [PR:000001200]
synonym: "chemokine receptor CCR4 signaling pathway" EXACT [GOC:bf]
is_a: GO:0070098 ! chemokine-mediated signaling pathway
created_by: rfoulger
creation_date: 2012-05-11T11:43:34Z

[Term]
id: GO:0038153
name: CCL2-activated CCR4 signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of the C-C chemokine CCL2 to a C-C chemokine type 4 receptor (CCR4) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling]
synonym: "CCL2/CCR4 signaling pathway" RELATED [GOC:bf]
is_a: GO:0038148 ! chemokine (C-C motif) ligand 2 signaling pathway
is_a: GO:0038152 ! C-C chemokine receptor CCR4 signaling pathway
created_by: rfoulger
creation_date: 2012-05-11T11:44:48Z

[Term]
id: GO:0038154
name: interleukin-11-mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of interleukin-11 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling]
synonym: "IL-11-mediated signaling pathway" EXACT [GOC:bf]
synonym: "interleukin-11-mediated signalling pathway" EXACT [GOC:bf]
is_a: GO:0019221 ! cytokine-mediated signaling pathway
created_by: rfoulger
creation_date: 2012-05-11T11:48:37Z

[Term]
id: GO:0038155
name: interleukin-23-mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of interleukin-23 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling]
synonym: "IL-23-mediated signaling pathway" EXACT [GOC:bf]
synonym: "interleukin-23-mediated signalling pathway" EXACT [GOC:bf]
is_a: GO:0019221 ! cytokine-mediated signaling pathway
created_by: rfoulger
creation_date: 2012-05-11T11:49:56Z

[Term]
id: GO:0038156
name: interleukin-3-mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of interleukin-3 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling]
synonym: "IL-3-mediated signaling pathway" EXACT [GOC:bf]
synonym: "interleukin-3-mediated signalling pathway" EXACT [GOC:bf]
is_a: GO:0019221 ! cytokine-mediated signaling pathway
created_by: rfoulger
creation_date: 2012-05-11T11:50:42Z

[Term]
id: GO:0038157
name: granulocyte-macrophage colony-stimulating factor signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of the cytokine granulocyte macrophage colony-stimulating factor (GM-CSF) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. GM-CSF binds to a heterodimer receptor (CSF2R) consisting of an alpha ligand-binding subunit, and a common beta subunit that is shared with other cytokine receptors." [GOC:nhn, GOC:signaling, PMID:17027509]
synonym: "CSF2 signaling pathway" EXACT [PR:000005931]
synonym: "GM-CSF receptor signaling pathway" EXACT [GOC:nhn]
synonym: "GM-CSF signaling pathway" EXACT [PR:000005931]
synonym: "granulocyte-macrophage colony-stimulating factor receptor signaling pathway" EXACT [GOC:nhn]
synonym: "granulocyte-macrophage colony-stimulating factor signalling pathway" RELATED [GOC:bf]
is_a: GO:0019221 ! cytokine-mediated signaling pathway
created_by: rfoulger
creation_date: 2012-05-14T01:22:15Z

[Term]
id: GO:0038158
name: granulocyte colony-stimulating factor signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of the cytokine granulocyte colony-stimulating factor (G-CSF) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. G-CSF binds to the receptor (CSF3R)." [GOC:nhn, GOC:signaling]
synonym: "CSF3 signaling pathway" EXACT [PR:000005932]
synonym: "G-CSF receptor signaling pathway" EXACT [GOC:nhn]
synonym: "G-CSF signaling pathway" EXACT [PR:000005932]
synonym: "granulocyte colony-stimulating factor receptor signaling pathway" EXACT [GOC:nhn]
synonym: "granulocyte colony-stimulating factor signalling pathway" RELATED [GOC:bf]
is_a: GO:0019221 ! cytokine-mediated signaling pathway
created_by: rfoulger
creation_date: 2012-05-14T01:30:28Z

[Term]
id: GO:0038159
name: C-X-C chemokine receptor CXCR4 signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by a the C-X-C chemokine type 4 receptor on the surface of a cell binding to one of it's physiological ligands, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling]
synonym: "CXCR4 signaling pathway" EXACT [PR:000001208]
is_a: GO:0070098 ! chemokine-mediated signaling pathway
created_by: rfoulger
creation_date: 2012-05-14T01:33:17Z

[Term]
id: GO:0038160
name: CXCL12-activated CXCR4 signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of the C-X-C chemokine CXCL12 to a C-X-C chemokine type 4 receptor (CXCR4) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn]
synonym: "CXCL12-activated CXCR4 signalling pathway" EXACT [GOC:bf]
is_a: GO:0038146 ! chemokine (C-X-C motif) ligand 12 signaling pathway
is_a: GO:0038159 ! C-X-C chemokine receptor CXCR4 signaling pathway
created_by: rfoulger
creation_date: 2012-05-14T01:33:17Z

[Term]
id: GO:0038161
name: prolactin signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of the peptide hormone prolactin to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:21664429]
synonym: "PRL signaling pathway" EXACT [PMID:21664429, PR:000013246]
synonym: "prolactin-mediated signaling pathway" EXACT [GOC:bf]
is_a: GO:0009755 ! hormone-mediated signaling pathway
is_a: GO:0019221 ! cytokine-mediated signaling pathway
created_by: rfoulger
creation_date: 2012-05-14T01:52:59Z

[Term]
id: GO:0038162
name: erythropoietin-mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of erythropoietin (EPO) to the erythropoietin receptor (EPO-R) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, PMID:12489509]
synonym: "EPO-R signaling pathway" EXACT [PMID:12489509]
synonym: "erythropoietin receptor signaling pathway" EXACT [PMID:12489509]
is_a: GO:0019221 ! cytokine-mediated signaling pathway
relationship: part_of GO:0036018 ! cellular response to erythropoietin
created_by: rfoulger
creation_date: 2012-05-14T02:28:38Z

[Term]
id: GO:0038163
name: thrombopoietin-mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of a thrombopoietin to the thrombopoietin receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:19630807]
synonym: "THPO signaling pathway" EXACT [PR:000016318]
synonym: "THPO/MPL signaling pathway" EXACT [PMID:18371409]
synonym: "thrombopoietin receptor signaling pathway" EXACT [GOC:nhn, PR:000001939]
is_a: GO:0070098 ! chemokine-mediated signaling pathway
created_by: rfoulger
creation_date: 2012-05-14T02:45:53Z

[Term]
id: GO:0038164
name: thrombopoietin receptor activity
namespace: molecular_function
def: "Combining with the glycoprotein thrombopoietin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, GOC:signaling, PMID:19630807]
is_a: GO:0004896 ! cytokine receptor activity
relationship: part_of GO:0038163 ! thrombopoietin-mediated signaling pathway
created_by: rfoulger
creation_date: 2012-05-14T02:46:58Z

[Term]
id: GO:0038165
name: oncostatin-M-mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of oncostatin-M (OSM) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. OSM can signal via at least two different receptors (a specific receptor and a LIF receptor) to activate different downstream signal transduction pathways." [GOC:nhn, GOC:signaling, PMID:10579456, PMID:12811586]
synonym: "oncostatin-M signaling pathway" EXACT [GOC:bf]
synonym: "OSM signaling pathway" EXACT [PMID:10579456, PR:000012059]
is_a: GO:0019221 ! cytokine-mediated signaling pathway
created_by: rfoulger
creation_date: 2012-05-14T02:54:30Z

[Term]
id: GO:0038166
name: angiotensin-activated signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of angiotensin II binding to an angiotensin receptor on the surface of the cell, and proceeding with the activated receptor transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity. Ends with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nhn, GOC:signaling, PMID:10977869]
synonym: "angiotensin II-mediated signaling pathway" EXACT [GOC:bf]
synonym: "angiotensin receptor signaling pathway" EXACT [GOC:bf, GOC:mtg_cardiac_conduct_nov11]
synonym: "angiotensin-mediated signaling pathway" RELATED []
is_a: GO:0007186 ! G-protein coupled receptor signaling pathway
relationship: part_of GO:1904385 ! cellular response to angiotensin
created_by: rfoulger
creation_date: 2012-05-14T03:09:03Z

[Term]
id: GO:0038167
name: epidermal growth factor receptor signaling pathway via positive regulation of NF-kappaB transcription factor activity
namespace: biological_process
def: "The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to one of its physiological ligands, where the signal is passed on within the cell via activation of the transcription factor NF-kappaB." [GOC:signaling, GOC:uh, PMID:21229383, PMID:21518868, PMID:22132240]
synonym: "EGFR signaling pathway via activation of NF-kappaB" EXACT [GOC:bf]
is_a: GO:0007173 ! epidermal growth factor receptor signaling pathway
relationship: has_part GO:0051092 ! positive regulation of NF-kappaB transcription factor activity
created_by: rfoulger
creation_date: 2012-05-15T11:49:30Z

[Term]
id: GO:0038168
name: epidermal growth factor receptor signaling pathway via I-kappaB kinase/NF-kappaB cascade
namespace: biological_process
def: "The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to one of its physiological ligands, where the signal is passed on within the cell via I-kappaB-kinase (IKK)-dependent activation of the transcription factor NF-kappaB." [GOC:bf, PMID:22132240]
synonym: "EGFR signaling pathway via IKK-dependent activation of NF-kappaB" EXACT [GOC:bf]
synonym: "EGFR signaling pathway via IKK/NF-kappaB cascade" EXACT [GOC:bf]
is_a: GO:0038167 ! epidermal growth factor receptor signaling pathway via positive regulation of NF-kappaB transcription factor activity
relationship: has_part GO:0007249 ! I-kappaB kinase/NF-kappaB signaling
created_by: rfoulger
creation_date: 2012-05-15T12:01:09Z

[Term]
id: GO:0038169
name: somatostatin receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a somatostatin receptor (SSTR) binding to one of its physiological ligands and transmitting the signal to a heterotrimeric G-protein complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:jc, PMID:18006219, PMID:8769369, PR:000001555]
comment: In addition to somatostatin (SST), the somatostatin receptors (SSTRs) can also be activated by the agonist cortistatin (CST). For signal transduction specifically initiated by the ligand somatostatin, consider instead annotating to the child term 'somatostatin signaling pathway ; GO:0038170'.
synonym: "SST receptor signaling pathway" EXACT [GOC:bf]
synonym: "SSTR signaling pathway" RELATED [GOC:bf]
is_a: GO:0007186 ! G-protein coupled receptor signaling pathway
created_by: rfoulger
creation_date: 2012-06-12T10:30:01Z

[Term]
id: GO:0038170
name: somatostatin signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of the peptide somatostatin (SST) binding to a somatostatin receptor (SSTR). The pathway proceeds with the receptor transmitting the signal to a heterotrimeric G-protein complex and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:nhn, GOC:signaling, PMID:18006219, Wikipedia:Somatostatin]
synonym: "somatostatin signalling pathway" EXACT [GOC:bf]
synonym: "somatostatin-activated somatostatin receptor signaling pathway" EXACT [GOC:bf]
synonym: "somatostatin-mediated signaling pathway" EXACT [GOC:bf]
synonym: "somatotrophin release inhibiting factor signaling pathway" EXACT [Wikipedia:Somatostatin]
synonym: "SRIF signaling pathway" EXACT [Wikipeda:Somatostatin]
synonym: "SST signaling pathway" EXACT [Wikipedia:Somatostatin]
is_a: GO:0009755 ! hormone-mediated signaling pathway
is_a: GO:0038169 ! somatostatin receptor signaling pathway
is_a: GO:0071375 ! cellular response to peptide hormone stimulus
created_by: rfoulger
creation_date: 2012-06-12T10:33:21Z

[Term]
id: GO:0038171
name: cannabinoid signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a cannabinoid binding to a cell surface receptor. The pathway proceeds with the receptor transmitting the signal to a heterotrimeric G-protein complex and ends with regulation of a downstream cellular process, e.g. transcription. Cannabinoids are a class of diverse chemical compounds that include the endocannabinoids and the phytocannabinoids." [GOC:bf, GOC:jc, GOC:signaling, Wikipedia:Cannabinoid]
synonym: "cannabinoid receptor signaling pathway" EXACT [GOC:bf]
synonym: "cannabinoid-activated signaling pathway" EXACT [GOC:bf]
synonym: "cannabinoid-mediated signaling pathway" EXACT [GOC:bf]
is_a: GO:0007186 ! G-protein coupled receptor signaling pathway
is_a: GO:0010033 ! response to organic substance
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: rfoulger
creation_date: 2012-06-12T10:47:53Z

[Term]
id: GO:0038172
name: interleukin-33-mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of interleukin-33 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:jc, GOC:signaling, PR:000001389]
synonym: "IL-33-mediated signaling pathway" EXACT [GOC:bf]
synonym: "IL33 signaling pathway" EXACT [PR:000001389]
synonym: "interleukin-33 signaling pathway" RELATED [GOC:jc]
synonym: "interleukin-33-mediated signalling pathway" EXACT [GOC:bf]
is_a: GO:0019221 ! cytokine-mediated signaling pathway
created_by: rfoulger
creation_date: 2012-06-12T10:57:35Z

[Term]
id: GO:0038173
name: interleukin-17A-mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of interleukin-17A to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:jc, GOC:signaling, PR:000001138]
synonym: "IL-17A-mediated signaling pathway" EXACT [GOC:bf]
synonym: "IL17A signaling pathway" EXACT [PR:000001138, Wikipedia:IL17A]
synonym: "IL17a signaling pathway" EXACT [GOC:jc]
synonym: "interleukin-17A signaling pathway" RELATED [GOC:jc]
synonym: "interleukin-17A-mediated signalling pathway" EXACT [GOC:bf]
is_a: GO:0019221 ! cytokine-mediated signaling pathway
created_by: rfoulger
creation_date: 2012-06-12T10:59:01Z

[Term]
id: GO:0038174
name: interleukin-17A receptor activity
namespace: molecular_function
def: "Combining with the cytokine interleukin-17A and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, GOC:jc, GOC:signaling, PR:000001138]
is_a: GO:0030368 ! interleukin-17 receptor activity
relationship: part_of GO:0038173 ! interleukin-17A-mediated signaling pathway
created_by: rfoulger
creation_date: 2012-06-12T11:01:25Z

[Term]
id: GO:0038175
name: negative regulation of SREBP signaling pathway in response to increased oxygen levels
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the SREBP signaling pathway in response to an increase in oxygen levels." [GOC:al, PMID:22017871]
synonym: "negative regulation of SREBP-mediated signaling pathway in presence of oxygen" RELATED [PMID:22017871]
synonym: "negative regulation of SREBP-mediated signaling pathway in response to increased oxygen levels" EXACT [GOC:bf, GOC:vw]
is_a: GO:2000639 ! negative regulation of SREBP signaling pathway
relationship: part_of GO:0036295 ! cellular response to increased oxygen levels
created_by: rfoulger
creation_date: 2012-07-20T01:28:59Z

[Term]
id: GO:0038176
name: positive regulation of SREBP signaling pathway in response to decreased oxygen levels
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the SREBP signaling pathway in response to a decrease in oxygen levels." [GOC:al, PMID:22017871]
synonym: "positive regulation of SREBP-mediated signaling pathway in absence of oxygen" RELATED [PMID:22017871]
synonym: "positive regulation of SREBP-mediated signaling pathway in response to decreased oxygen levels" EXACT [GOC:bf, GOC:vw]
is_a: GO:2000640 ! positive regulation of SREBP signaling pathway
relationship: part_of GO:0036294 ! cellular response to decreased oxygen levels
created_by: rfoulger
creation_date: 2012-07-20T01:30:25Z

[Term]
id: GO:0038177
name: death receptor agonist activity
namespace: molecular_function
def: "Interacting with a death receptor such that the proportion of death receptors in an active form is increased. Ligand binding to a death receptor often induces a conformational change to activate the receptor." [GOC:mtg_apoptosis, GOC:pr]
synonym: "death receptor activator activity" EXACT [GOC:pr]
is_a: GO:0048018 ! receptor agonist activity
relationship: has_part GO:0005123 ! death receptor binding
created_by: rfoulger
creation_date: 2012-09-20T12:52:00Z

[Term]
id: GO:0038178
name: complement component C5a signaling pathway
namespace: biological_process
def: "A series of molecular signals generated as a consequence of a the C5a component of the complement pathway binding to a complement receptor, and ending with regulation of a downstream cellular process. C5a is a peptide derived from the C5 complement factor." [GOC:jc, PMID:15313431, Wikipedia:Complement_component_5a]
synonym: "complement component C5a-induced signaling pathway" EXACT [GOC:jc]
is_a: GO:0002430 ! complement receptor mediated signaling pathway
is_a: GO:0007186 ! G-protein coupled receptor signaling pathway
created_by: rfoulger
creation_date: 2012-09-21T10:55:00Z

[Term]
id: GO:0038179
name: neurotrophin signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of a neurotrophin to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Neurotrophins are a family of secreted growth factors that induce the survival, development, and function of neurons." [GOC:bf, GOC:jc, GOC:signaling, PMID:17466268, PR:000021998, Wikipedia:Neurotrophin]
comment: There are two classes of receptors for neurotrophins: p75 and the Trk family of tyrosine kinase receptors.
synonym: "neurotrophin receptor signaling pathway" EXACT [PMID:22333586]
is_a: GO:0007166 ! cell surface receptor signaling pathway
relationship: part_of GO:0071363 ! cellular response to growth factor stimulus
created_by: rfoulger
creation_date: 2013-03-27T17:22:44Z

[Term]
id: GO:0038180
name: nerve growth factor signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of nerve growth factor (NGF) to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, PMID:11520933, PR:000011194, Wikipedia:Nerve_growth_factor]
comment: Nerve growth factor (NGF) binds at least two classes of receptors: the p75 LNGFR (low-affinity nerve growth factor receptor) and TrkA, a transmembrane tyrosine kinase.
synonym: "nerve growth factor signalling pathway" EXACT [GOC:bf]
synonym: "NGF signaling pathway" EXACT [PR:000011194, Wikipedia:Nerve_growth_factor]
is_a: GO:0038179 ! neurotrophin signaling pathway
relationship: part_of GO:1990090 ! cellular response to nerve growth factor stimulus
created_by: rfoulger
creation_date: 2013-05-15T11:04:05Z

[Term]
id: GO:0038181
name: bile acid receptor activity
namespace: molecular_function
def: "Combining with a bile acid and transmitting the signal to initiate a change in cell activity. A bile acid is any member of a group of steroid carboxylic acids occurring in bile." [CHEBI:3098, GOC:bf, PMID:10334992, PMID:12718893]
is_a: GO:0038023 ! signaling receptor activity
relationship: has_part GO:0032052 ! bile acid binding
relationship: part_of GO:0038183 ! bile acid signaling pathway
created_by: rfoulger
creation_date: 2013-05-16T10:27:02Z

[Term]
id: GO:0038182
name: G-protein coupled bile acid receptor activity
namespace: molecular_function
def: "Combining with an extracellular bile acid and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, PMID:12524422, Wikipedia:G_protein-coupled_bile_acid_receptor]
synonym: "cell surface bile acid receptor" BROAD [GOC:bf]
synonym: "membrane bile acid receptor activity" BROAD [PMID:12419312]
xref: Wikipedia:G_protein-coupled_bile_acid_receptor
is_a: GO:0004930 ! G-protein coupled receptor activity
is_a: GO:0038181 ! bile acid receptor activity
relationship: part_of GO:0038184 ! cell surface bile acid receptor signaling pathway
created_by: rfoulger
creation_date: 2013-05-16T10:29:42Z

[Term]
id: GO:0038183
name: bile acid signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of a bile acid to a receptor, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:signaling, PMID:12016314]
is_a: GO:0007165 ! signal transduction
created_by: rfoulger
creation_date: 2013-05-16T10:35:10Z

[Term]
id: GO:0038184
name: cell surface bile acid receptor signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by binding of a bile acid to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, PMID:12419312, PMID:19442546]
synonym: "membrane bile acid receptor signaling pathway" RELATED [GOC:bf]
is_a: GO:0007166 ! cell surface receptor signaling pathway
is_a: GO:0038183 ! bile acid signaling pathway
created_by: rfoulger
creation_date: 2013-05-16T11:00:42Z

[Term]
id: GO:0038185
name: intracellular bile acid receptor signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by a bile acid binding to an receptor located within a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, PMID:10334992]
synonym: "nuclear bile acid receptor signaling pathway" RELATED []
is_a: GO:0030522 ! intracellular receptor signaling pathway
is_a: GO:0038183 ! bile acid signaling pathway
created_by: rfoulger
creation_date: 2013-05-16T11:08:02Z

[Term]
id: GO:0038186
name: lithocholic acid receptor activity
namespace: molecular_function
def: "Combining with lithocholic acid and transmitting the signal to initiate a change in cell activity." [CHEBI:16325, GOC:bf, PMID:12016314, PMID:12419312]
synonym: "LCA receptor activity" EXACT [PMID:10334992]
is_a: GO:0038181 ! bile acid receptor activity
relationship: has_part GO:1902121 ! lithocholic acid binding
created_by: rfoulger
creation_date: 2013-05-16T11:13:38Z

[Term]
id: GO:0038187
name: pattern recognition receptor activity
namespace: molecular_function
def: "Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species, or damage-associated molecular pattern (DAMP), an endogenous molecule released from damaged cells), to initiate a change in cell activity." [GOC:ar, GOC:bf, Wikipedia:Pattern_recognition_receptor]
comment: Pattern recognition receptors can be signaling (binding to a ligand and transmitting the signal within the cell) or endocytic (binding to a ligand and promoting the attachment, engulfment and destruction of microorganisms by phagocytes, without relaying an intracellular signal).
synonym: "PRR activity" EXACT [Wikipedia:Pattern_recognition_receptor]
is_a: GO:0004872 ! receptor activity
relationship: has_part GO:0001871 ! pattern binding
created_by: rfoulger
creation_date: 2013-05-29T15:24:44Z

[Term]
id: GO:0038188
name: cholecystokinin signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of cholecystokinin binding to a receptor on the surface of the cell, and proceeding with the activated receptor transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity. Ends with regulation of a downstream cellular process, e.g. transcription." [GOC:jc, PMID:11181948]
synonym: "CCK signaling" EXACT [PMID:11181948, Wikipedia:Cholecystokinin]
synonym: "cholecystokinin receptor signaling pathway" RELATED [GOC:bf]
is_a: GO:0007186 ! G-protein coupled receptor signaling pathway
created_by: rfoulger
creation_date: 2013-07-01T13:05:46Z

[Term]
id: GO:0038189
name: neuropilin signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of an extracellular ligand to an neuropilin protein on the surface of a target cell, followed by transmission of the signal, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, PMID:12852851]
synonym: "Npn signaling" EXACT [PMID:12852851]
is_a: GO:0007166 ! cell surface receptor signaling pathway
created_by: rfoulger
creation_date: 2013-08-01T16:02:10Z

[Term]
id: GO:0038190
name: VEGF-activated neuropilin signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of vascular endothelial growth factor (VEGF) to a neuropilin protein on the surface of a target cell, followed by transmission of the signal, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:rl, PMID:12852851]
synonym: "vascular endothelial growth factor-activated neuropilin signaling pathway" RELATED [GOC:bf]
synonym: "VEGF-Npn-1 signaling" NARROW [PMID:12852851]
is_a: GO:0038084 ! vascular endothelial growth factor signaling pathway
is_a: GO:0038189 ! neuropilin signaling pathway
relationship: has_part GO:0005021 ! vascular endothelial growth factor-activated receptor activity
created_by: rfoulger
creation_date: 2013-08-01T16:06:49Z

[Term]
id: GO:0038191
name: neuropilin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a member of the neuropilin family." [GOC:bf, PMID:23871893]
synonym: "neuropilin-binding" EXACT [PMID:12852851]
synonym: "Nrp binding" EXACT [PMID:23871893]
synonym: "Nrp ligand" NARROW [PMID:23871893]
is_a: GO:0005102 ! receptor binding
created_by: rfoulger
creation_date: 2013-08-01T16:11:33Z

[Term]
id: GO:0038192
name: gastric inhibitory peptide signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a gastric inhibitory peptide (GIP) binding to a cell surface receptor. The pathway proceeds with the receptor transmitting the signal to a heterotrimeric G-protein complex and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, PMID:15955806]
synonym: "gastric inhibitory polypeptide receptor signaling pathway" EXACT [GOC:nhn]
synonym: "GIP signaling" EXACT [PMID:19251046]
synonym: "glucose-dependent insulinotropic polypeptide signaling" EXACT [PMID:19251046]
is_a: GO:0007186 ! G-protein coupled receptor signaling pathway
created_by: rfoulger
creation_date: 2013-09-02T15:57:49Z

[Term]
id: GO:0038193
name: thromboxane A2 signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of thromboxane A2 binding to a cell surface receptor. The pathway proceeds with the receptor transmitting the signal to a heterotrimeric G-protein complex and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, PMID:15893915]
synonym: "TXA(2) receptor signaling" EXACT [PMID:15893915]
synonym: "TXA2 signaling" EXACT [PMID:15242977]
is_a: GO:0007186 ! G-protein coupled receptor signaling pathway
created_by: rfoulger
creation_date: 2013-09-02T16:07:01Z

[Term]
id: GO:0038194
name: thyroid-stimulating hormone signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of thyroid-stimulating hormone (thyrotropin) binding to a cell surface receptor. The pathway proceeds with the receptor transmitting the signal to a heterotrimeric G-protein complex and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:gap, PMID:10809230]
synonym: "thyrotropin signaling pathway" EXACT [GOC:gap, PMID:10809230]
synonym: "TSH signaling pathway" EXACT [PMID:10809230]
is_a: GO:0007186 ! G-protein coupled receptor signaling pathway
created_by: rfoulger
creation_date: 2013-10-28T09:03:48Z

[Term]
id: GO:0038195
name: urokinase plasminogen activator signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of urokinase plasminogen activator to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:gap, PMID:9417082]
synonym: "uPA signaling pathway" EXACT [PMID:9417082]
is_a: GO:0007166 ! cell surface receptor signaling pathway
created_by: rfoulger
creation_date: 2013-10-28T09:14:13Z

[Term]
id: GO:0038196
name: type III interferon signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of a type III interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon lambda is the only member of the type III interferon found so far." [GOC:pg, GOC:signaling]
synonym: "interferon lambda signaling pathway" NARROW [PR:000001362]
synonym: "type III interferon-activated signaling pathway" EXACT [GOC:signaling]
is_a: GO:0019221 ! cytokine-mediated signaling pathway
relationship: part_of GO:0071358 ! cellular response to type III interferon
created_by: rfoulger
creation_date: 2013-11-27T14:25:49Z

[Term]
id: GO:0038197
name: type I interferon receptor complex
namespace: cellular_component
def: "A heterodimeric protein complex that binds a type I interferon and transmits the signal across the membrane into the cell. Consists of an alpha subunit (IFNAR1) and a beta subunit (IFNAR2)." [GOC:cjm, GOC:signaling, PMID:17502368]
synonym: "interferon-alpha/beta receptor complex" NARROW [GOC:bf]
is_a: GO:0098802 ! plasma membrane receptor complex
relationship: part_of GO:0005887 ! integral component of plasma membrane
created_by: rfoulger
creation_date: 2013-11-27T14:53:50Z

[Term]
id: GO:0038198
name: auxin receptor activity
namespace: molecular_function
def: "Combining with auxin and transmitting the signal in the cell to initiate a change in cell activity. Auxin is a plant hormone (phytohormone)." [GOC:signaling, PMID:15917797]
is_a: GO:0038023 ! signaling receptor activity
relationship: has_part GO:0010011 ! auxin binding
relationship: part_of GO:0009734 ! auxin-activated signaling pathway
created_by: rfoulger
creation_date: 2013-12-05T15:47:42Z

[Term]
id: GO:0038199
name: ethylene receptor activity
namespace: molecular_function
def: "Combining with ethylene and transmitting the signal in the cell to initiate a change in cell activity." [GOC:signaling, PMID:22467798, PMID:24012247]
synonym: "C2H4 receptor activity" EXACT [PMID:24012247]
synonym: "ethylene response sensor" RELATED [PMID:22467798]
is_a: GO:0038023 ! signaling receptor activity
relationship: has_part GO:0051740 ! ethylene binding
relationship: part_of GO:0009873 ! ethylene-activated signaling pathway
created_by: rfoulger
creation_date: 2013-12-05T16:06:13Z

[Term]
id: GO:0038200
name: ethylene receptor histidine kinase activity
namespace: molecular_function
def: "Combining with ethylene and transmitting the signal within the cell to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-histidine = ADP + a protein-L-histidine phosphate." [GOC:signaling, PMID:22467798]
is_a: GO:0038199 ! ethylene receptor activity
relationship: has_part GO:0004673 ! protein histidine kinase activity
created_by: rfoulger
creation_date: 2013-12-05T16:25:15Z

[Term]
id: GO:0038201
name: TOR complex
namespace: cellular_component
def: "A protein complex that contains at least TOR (target of rapamycin) in complex with other signaling components. Mediates the phosphorylation and activation of downstream signaling components including PKB (AKT) or S6K." [Wikipedia:MTORC1, Wikipedia:MTORC2]
synonym: "mTOR complex" NARROW [Wikipedia:MTORC1]
synonym: "target of rapamycin complex" EXACT [GOC:bf]
synonym: "TOR signaling complex" EXACT [GOC:bf]
is_a: GO:0044424 ! intracellular part
created_by: rfoulger
creation_date: 2013-12-09T14:38:09Z

[Term]
id: GO:0038202
name: TORC1 signaling
namespace: biological_process
def: "A series of intracellular molecular signals mediated by TORC1; TOR (target of rapamycin) in complex with at least Raptor (regulatory-associated protein of TOR), or orthologs of, and other signaling components." [GOC:lb]
synonym: "TORC1 signal transduction" EXACT [GOC:signaling]
is_a: GO:0031929 ! TOR signaling
created_by: rfoulger
creation_date: 2013-12-09T14:43:29Z

[Term]
id: GO:0038203
name: TORC2 signaling
namespace: biological_process
def: "A series of intracellular molecular signals mediated by TORC2; TOR (rapamycin-insensitive companion of TOR) in complex with at least Rictor (regulatory-associated protein of TOR), or orthologs of, and other signaling components." [GOC:lb]
synonym: "TORC2 signal transduction" EXACT [GOC:signaling]
is_a: GO:0031929 ! TOR signaling
created_by: rfoulger
creation_date: 2013-12-09T14:43:29Z

[Term]
id: GO:0039003
name: pronephric field specification
namespace: biological_process
def: "The process in which regions of the embryo are delineated into the area in which the pronephric kidney will develop." [GOC:mtg_kidney_jan10]
synonym: "pronephric kidney field specification" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0039017 ! pattern specification involved in pronephros development
is_a: GO:0072004 ! kidney field specification
relationship: part_of GO:0048793 ! pronephros development
created_by: rfoulger
creation_date: 2010-07-02T09:28:16Z

[Term]
id: GO:0039004
name: specification of pronephric proximal tubule identity
namespace: biological_process
def: "The process in which the proximal tubule of the pronephric nephron acquires its identity." [GOC:mtg_kidney_jan10]
is_a: GO:0039005 ! specification of pronephric tubule identity
is_a: GO:0072082 ! specification of proximal tubule identity
is_a: GO:0072196 ! proximal/distal pattern formation involved in pronephric nephron development
relationship: part_of GO:0039011 ! pronephric proximal tubule morphogenesis
created_by: rfoulger
creation_date: 2010-07-02T09:30:30Z

[Term]
id: GO:0039005
name: specification of pronephric tubule identity
namespace: biological_process
def: "The process in which the tubules arranged along the proximal/distal axis of the pronephric nephron acquire their identity." [GOC:mtg_kidney_jan10]
is_a: GO:0039017 ! pattern specification involved in pronephros development
is_a: GO:0072081 ! specification of nephron tubule identity
relationship: part_of GO:0039008 ! pronephric nephron tubule morphogenesis
created_by: rfoulger
creation_date: 2010-07-02T09:33:56Z

[Term]
id: GO:0039006
name: pronephric nephron tubule formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a pronephric nephron tubule from unspecified parts. A pronephric nephron tubule is an epithelial tube that is part of a nephron in the pronephros." [GOC:mtg_kidney_jan10]
synonym: "pronephric tubule formation" EXACT [GOC:mtg_kidney_jan10]
synonym: "pronephros tubule formation" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072079 ! nephron tubule formation
relationship: part_of GO:0039008 ! pronephric nephron tubule morphogenesis
relationship: part_of GO:0072116 ! pronephros formation
created_by: rfoulger
creation_date: 2010-07-02T09:37:27Z

[Term]
id: GO:0039007
name: pronephric nephron morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the pronephric nephron are generated and organized. A pronephric nephron is the functional unit of the pronephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072028 ! nephron morphogenesis
relationship: part_of GO:0039019 ! pronephric nephron development
relationship: part_of GO:0072114 ! pronephros morphogenesis
created_by: rfoulger
creation_date: 2010-07-02T09:38:53Z

[Term]
id: GO:0039008
name: pronephric nephron tubule morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a pronephric nephron tubule are generated and organized from an epithelium. A pronephric nephron tubule is an epithelial tube that is part of the pronephric nephron." [GOC:mtg_kidney_jan10, ZFA:00001558]
is_a: GO:0072078 ! nephron tubule morphogenesis
relationship: part_of GO:0039007 ! pronephric nephron morphogenesis
relationship: part_of GO:0039020 ! pronephric nephron tubule development
created_by: rfoulger
creation_date: 2010-07-02T09:45:55Z

[Term]
id: GO:0039009
name: rectal diverticulum development
namespace: biological_process
def: "The process whose specific outcome is the progression of the rectal diverticulum over time, from its formation to the mature structure. The rectal diverticulum is an outgrowth of the cloaca and links the pronephric kidney to the exterior." [GOC:mtg_kidney_jan10, PMID:10535314, PMID:18226983, XAO:0001015]
synonym: "pronephric rectal diverticulum development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048793 ! pronephros development
created_by: rfoulger
creation_date: 2010-07-02T09:48:58Z

[Term]
id: GO:0039010
name: specification of pronephric distal tubule identity
namespace: biological_process
def: "The process in which the distal tubule of the pronephric nephron acquires its identity." [GOC:mtg_kidney_jan10]
is_a: GO:0039005 ! specification of pronephric tubule identity
is_a: GO:0072084 ! specification of distal tubule identity
is_a: GO:0072196 ! proximal/distal pattern formation involved in pronephric nephron development
relationship: part_of GO:0039013 ! pronephric distal tubule morphogenesis
created_by: rfoulger
creation_date: 2010-07-02T09:51:28Z

[Term]
id: GO:0039011
name: pronephric proximal tubule morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a pronephric nephron proximal tubule are generated and organized. A pronephric nephron tubule is an epithelial tube that is part of the pronephros." [GOC:mtg_kidney_jan10]
synonym: "pronephros proximal tubule morphogenesis" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0039008 ! pronephric nephron tubule morphogenesis
is_a: GO:0072158 ! proximal tubule morphogenesis
relationship: part_of GO:0035776 ! pronephric proximal tubule development
created_by: rfoulger
creation_date: 2010-07-02T09:53:12Z

[Term]
id: GO:0039012
name: pronephric sinus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pronephric sinus over time, from its formation to the mature structure. The pronephric sinus is an ill-defined capillary network that lies between the pronephric tubules." [GOC:mtg_kidney_jan10, PMID:10535314, XAO:0000385]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048793 ! pronephros development
created_by: rfoulger
creation_date: 2010-07-02T09:55:23Z

[Term]
id: GO:0039013
name: pronephric distal tubule morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a pronephric nephron distal tubule are generated and organized. A pronephric nephron tubule is an epithelial tube that is part of the pronephros." [GOC:mtg_kidney_jan10]
is_a: GO:0039008 ! pronephric nephron tubule morphogenesis
is_a: GO:0072156 ! distal tubule morphogenesis
relationship: part_of GO:0035777 ! pronephric distal tubule development
created_by: rfoulger
creation_date: 2010-07-02T09:58:03Z

[Term]
id: GO:0039014
name: cell differentiation involved in pronephros development
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the pronephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
synonym: "cell differentiation involved in pronephric kidney development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0061005 ! cell differentiation involved in kidney development
intersection_of: GO:0030154 ! cell differentiation
intersection_of: part_of GO:0048793 ! pronephros development
relationship: part_of GO:0048793 ! pronephros development
created_by: rfoulger
creation_date: 2010-07-02T09:59:25Z

[Term]
id: GO:0039015
name: cell proliferation involved in pronephros development
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of the population in the pronephros." [GOC:mtg_kidney_jan10]
synonym: "cell proliferation involved in pronephric kidney development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072111 ! cell proliferation involved in kidney development
intersection_of: GO:0008283 ! cell proliferation
intersection_of: part_of GO:0048793 ! pronephros development
relationship: part_of GO:0048793 ! pronephros development
created_by: rfoulger
creation_date: 2010-07-02T10:01:49Z

[Term]
id: GO:0039016
name: cell-cell signaling involved in pronephros development
namespace: biological_process
def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the pronephros over time, from its formation to the mature organ." [GOC:mtg_kidney_jan10]
synonym: "cell-cell signaling involved in pronephric kidney development" EXACT [GOC:mtg_kidney_jan10]
synonym: "cell-cell signalling involved in pronephros development" EXACT [GOC:mah]
is_a: GO:0060995 ! cell-cell signaling involved in kidney development
intersection_of: GO:0007267 ! cell-cell signaling
intersection_of: part_of GO:0048793 ! pronephros development
relationship: part_of GO:0048793 ! pronephros development
created_by: rfoulger
creation_date: 2010-07-02T10:03:16Z

[Term]
id: GO:0039017
name: pattern specification involved in pronephros development
namespace: biological_process
def: "Any developmental process that results in the creation of defined areas or spaces within the pronephros to which cells respond and eventually are instructed to differentiate." [GOC:mtg_kidney_jan10]
synonym: "pattern specification involved in pronephric kidney development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0061004 ! pattern specification involved in kidney development
intersection_of: GO:0007389 ! pattern specification process
intersection_of: part_of GO:0048793 ! pronephros development
relationship: part_of GO:0048793 ! pronephros development
created_by: rfoulger
creation_date: 2010-07-02T10:04:39Z

[Term]
id: GO:0039018
name: nephrostome development
namespace: biological_process
def: "The process whose specific outcome is the progression of the nephrostome over time, from its formation to the mature structure. The nephrostome is the opening of the pronephros into the body cavity." [GOC:mtg_kidney_jan10, PMID:14686690, PMID:15647339, XAO:0000062]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048793 ! pronephros development
created_by: rfoulger
creation_date: 2010-07-02T10:08:16Z

[Term]
id: GO:0039019
name: pronephric nephron development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pronephric nephron over time, from its formation to the mature structure. A pronephric nephron is the functional unit of the pronephros." [GOC:mtg_kidney_jan10, XAO:00002785]
is_a: GO:0072006 ! nephron development
relationship: part_of GO:0048793 ! pronephros development
created_by: rfoulger
creation_date: 2010-07-02T10:10:20Z

[Term]
id: GO:0039020
name: pronephric nephron tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of a pronephric nephron tubule over time, from its formation to the mature structure. The pronephric nephron tubule is an epithelial tube that is part of the pronephric nephron and connects the filtration unit (glomerulus or glomus) of the pronephros to the pronephric duct." [GOC:mtg_kidney_jan10, PMID:19909807, PMID:9268568]
is_a: GO:0072080 ! nephron tubule development
relationship: part_of GO:0039019 ! pronephric nephron development
created_by: rfoulger
creation_date: 2010-07-02T10:11:36Z

[Term]
id: GO:0039021
name: pronephric glomerulus development
namespace: biological_process
def: "The progression of the glomerulus of the pronephric kidney over time from its initial formation until its mature state. The pronephric glomerulus is part of the pronephric nephron and is restricted to one body segment." [GOC:dgh, GOC:mtg_kidney_jan10, ZFA:00001557]
comment: This term is intended for annotation of fish and other organisms which contain a glomerulus as part of the pronephric nephron. It should not be used for annotation of Xenopus, which contains a pronephric glomus rather than a glomerulus.
is_a: GO:0032835 ! glomerulus development
relationship: part_of GO:0039019 ! pronephric nephron development
created_by: rfoulger
creation_date: 2010-07-02T10:13:38Z

[Term]
id: GO:0039022
name: pronephric duct development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pronephric duct over time, from its formation to the mature structure. The pronephric duct collects the filtrate from the pronephric tubules and opens to the exterior of the pronephric kidney." [GOC:mtg_kidney_jan10, PMID:15647339, XAO:0000063, ZFA:0000150]
is_a: GO:0072176 ! nephric duct development
relationship: part_of GO:0048793 ! pronephros development
created_by: rfoulger
creation_date: 2010-07-02T10:15:03Z

[Term]
id: GO:0039023
name: pronephric duct morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the pronephric duct are generated and organized. The pronephric duct collects the filtrate from the pronephric tubules and opens to the exterior of the kidney." [GOC:mtg_kidney_jan10, XAO:0000063, ZFA:0000150]
is_a: GO:0072178 ! nephric duct morphogenesis
relationship: part_of GO:0039022 ! pronephric duct development
relationship: part_of GO:0072114 ! pronephros morphogenesis
created_by: rfoulger
creation_date: 2010-07-02T10:18:09Z

[Term]
id: GO:0039501
name: suppression by virus of host type I interferon production
namespace: biological_process
def: "Any viral process that results in the inhibition of host cell type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:bf, GOC:sp, UniProtKB-KW:KW-1113, VZ:875]
subset: virus_checked
synonym: "negative regulation by virus of host type I interferon production" EXACT [GOC:bf]
synonym: "suppression by virus of host interferon type I production" EXACT [GOC:bf]
synonym: "suppression by virus of host type I IFN production" EXACT [GOC:bf]
xref: VZ:875 "Inhibition of host IFN-mediated response initiation by virus"
is_a: GO:0032480 ! negative regulation of type I interferon production
is_a: GO:0046775 ! suppression by virus of host cytokine production
created_by: rfoulger
creation_date: 2011-05-11T03:53:20Z

[Term]
id: GO:0039502
name: suppression by virus of host type I interferon-mediated signaling pathway
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of type I interferon-mediated signaling in the host organism. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:bf, GOC:sp, UniProtKB-KW:KW-1114, VZ:883]
subset: virus_checked
synonym: "inhibition of host interferon signaling pathway by virus" RELATED [UniProtKB-KW:KW-1114]
synonym: "negative regulation by virus of host type I interferon-mediated signaling pathway" EXACT [GOC:bf]
synonym: "suppression by virus of host type I IFN-mediated signaling pathway" EXACT [GOC:bf]
synonym: "suppression by virus of host type I interferon-mediated signalling pathway" EXACT [GOC:bf]
xref: VZ:883 "Inhibition of host IFN-mediated response initiation by virus"
is_a: GO:0039503 ! suppression by virus of host innate immune response
is_a: GO:0060339 ! negative regulation of type I interferon-mediated signaling pathway
is_a: GO:0075114 ! negative regulation by symbiont of host transmembrane receptor-mediated signal transduction
intersection_of: GO:0019054 ! modulation by virus of host process
intersection_of: negatively_regulates GO:0060337 ! type I interferon signaling pathway
relationship: negatively_regulates GO:0060337 ! type I interferon signaling pathway
created_by: rfoulger
creation_date: 2011-05-11T04:06:28Z

[Term]
id: GO:0039503
name: suppression by virus of host innate immune response
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the innate immune response of the host organism, the host's first line of defense." [GOC:add, GOC:bf, GOC:sp, UniProtKB-KW:KW-1090]
subset: virus_checked
synonym: "inhibition of host innate immune response by virus" EXACT [UniProtKB-KW:KW-1090]
synonym: "negative regulation by virus of host innate immune response" EXACT [GOC:bf]
synonym: "negative regulation by virus of host innate immunity" EXACT [GOC:bf]
synonym: "suppression by virus of host innate immunity" EXACT [GOC:pg]
is_a: GO:0030683 ! evasion or tolerance by virus of host immune response
is_a: GO:0052170 ! negative regulation by symbiont of host innate immune response
is_a: GO:0075528 ! modulation by virus of host immune response
intersection_of: GO:0019054 ! modulation by virus of host process
intersection_of: negatively_regulates GO:0045087 ! innate immune response
relationship: negatively_regulates GO:0045087 ! innate immune response
created_by: rfoulger
creation_date: 2011-05-11T04:31:17Z

[Term]
id: GO:0039504
name: suppression by virus of host adaptive immune response
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the adaptive immune response of the host organism, an immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory)." [GOC:add, GOC:bf, GOC:sp, UniProtKB-KW:KW-1080]
subset: virus_checked
synonym: "inhibition of host adaptive immune response by virus" EXACT [UniProtKB-KW:KW-1080]
synonym: "negative regulation by virus of host adaptive immune response" EXACT [GOC:bf]
synonym: "negative regulation by virus of host adaptive immunity" EXACT [GOC:bf]
synonym: "suppression by virus of host acquired immune response" EXACT [ISBN:068340007X]
is_a: GO:0002820 ! negative regulation of adaptive immune response
is_a: GO:0030683 ! evasion or tolerance by virus of host immune response
is_a: GO:0052562 ! negative regulation by symbiont of host immune response
is_a: GO:0075528 ! modulation by virus of host immune response
intersection_of: GO:0019054 ! modulation by virus of host process
intersection_of: negatively_regulates GO:0002250 ! adaptive immune response
relationship: negatively_regulates GO:0002250 ! adaptive immune response
created_by: rfoulger
creation_date: 2011-05-11T04:41:54Z

[Term]
id: GO:0039505
name: suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II
namespace: biological_process
def: "Any viral process that inhibits a host antigen-presenting cell expressing a peptide antigen on its cell surface in association with an MHC class II protein complex." [GOC:add, GOC:bf, UniProtKB-KW:KW-1116, VZ:820]
subset: virus_checked
synonym: "inhibition of host MHC class II molecule presentation by virus" RELATED [UniProtKB-KW:KW-1116]
xref: VZ:820 "Inhibition of host MHC class II molecule presentation by virus"
is_a: GO:0002587 ! negative regulation of antigen processing and presentation of peptide antigen via MHC class II
is_a: GO:0039588 ! suppression by virus of host antigen processing and presentation
intersection_of: GO:0019054 ! modulation by virus of host process
intersection_of: negatively_regulates GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II
relationship: negatively_regulates GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II
created_by: rfoulger
creation_date: 2011-06-02T02:34:51Z

[Term]
id: GO:0039506
name: modulation by virus of host molecular function
namespace: biological_process
def: "The process in which a virus effects a change in the function of a host protein via a direct interaction." [GOC:bf, GOC:sp]
subset: virus_checked
synonym: "modification by virus of host protein function" EXACT [GOC:bf]
is_a: GO:0019048 ! modulation by virus of host morphology or physiology
is_a: GO:0052055 ! modulation by symbiont of host molecular function
created_by: rfoulger
creation_date: 2011-06-02T02:38:42Z

[Term]
id: GO:0039507
name: suppression by virus of host molecular function
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the functional activity of a host protein." [GOC:bf, GOC:sp]
subset: virus_checked
synonym: "down regulation by virus of host protein function" EXACT [GOC:bf]
synonym: "down-regulation by virus of host protein function" EXACT [GOC:bf]
synonym: "inhibition by virus of host protein function" NARROW [GOC:bf]
synonym: "inhibition of host protein function" NARROW [GOC:bf]
synonym: "negative regulation by virus of host molecular function" EXACT [GOC:bf]
synonym: "negative regulation by virus of host protein function" EXACT [GOC:bf]
is_a: GO:0039506 ! modulation by virus of host molecular function
is_a: GO:0052056 ! negative regulation by symbiont of host molecular function
created_by: rfoulger
creation_date: 2011-06-02T02:47:03Z

[Term]
id: GO:0039508
name: suppression by virus of host receptor activity
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the functional activity of a host receptor." [GOC:bf, GOC:sp]
subset: virus_checked
synonym: "down-regulation by virus of host receptor activity" EXACT [GOC:bf]
synonym: "downregulation by virus of host receptor activity" EXACT [GOC:bf]
synonym: "inhibition by virus of host receptor activity" NARROW [GOC:bf]
synonym: "negative regulation by virus of host receptor activity" EXACT [GOC:bf]
synonym: "suppression by virus of host receptor function" EXACT [GOC:bf]
synonym: "viral inhibition of host receptor" EXACT [GOC:bf]
is_a: GO:0039507 ! suppression by virus of host molecular function
created_by: rfoulger
creation_date: 2011-06-02T03:09:37Z

[Term]
id: GO:0039509
name: suppression by virus of host pattern recognition receptor activity
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the functional activity of a host pattern recognition receptor. A pattern recognition receptor combines with a molecular pattern based on a repeating or polymeric structure, such as a polysaccharide or peptidoglycan, to initiate a change in cell activity." [GOC:bf, GOC:sp]
subset: virus_checked
synonym: "down regulation by virus of host pattern recognition receptor activity" EXACT [GOC:bf]
synonym: "down-regulation by virus of host pattern recognition receptor activity" EXACT [GOC:bf]
synonym: "inhibition by virus of host pattern recognition receptor activity" NARROW [GOC:rf]
synonym: "negative regulation by virus of host pattern recognition receptor activity" EXACT [GOC:bf]
synonym: "suppression by virus of host pattern recognition receptor function" EXACT [GOC:bf]
synonym: "viral inhibition of host pattern recognition receptor activity" NARROW [GOC:bf]
is_a: GO:0039508 ! suppression by virus of host receptor activity
created_by: rfoulger
creation_date: 2011-06-02T03:11:23Z

[Term]
id: GO:0039510
name: suppression by virus of host ATP-dependent RNA helicase activity
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host ATP-dependent RNA helicase activity." [GOC:bf, GOC:sp]
subset: virus_checked
synonym: "down-regulation by virus of host ATP-dependent RNA helicase activity" EXACT [GOC:bf]
synonym: "downregulation by virus of host ATP-dependent RNA helicase activity" EXACT [GOC:bf]
synonym: "inhibition by virus of host ATP-dependent RNA helicase activity" NARROW [GOC:bf]
synonym: "negative regulation by virus of host ATP-dependent RNA helicase activity" EXACT [GOC:bf]
is_a: GO:0039513 ! suppression by virus of host catalytic activity
is_a: GO:1902281 ! negative regulation of ATP-dependent RNA helicase activity
created_by: rfoulger
creation_date: 2011-06-16T02:11:00Z

[Term]
id: GO:0039511
name: suppression by virus of host interferon receptor activity
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the functional activity of a host interferon receptor." [GOC:bf, GOC:sp, UniProtKB-KW:KW-1091, VZ:843]
subset: virus_checked
synonym: "down-regulation by virus of host interferon receptor activity" EXACT [GOC:bf]
synonym: "downregulation by virus of host interferon receptor activity" EXACT [GOC:bf]
synonym: "inhibition by virus of host interferon receptor activity" NARROW [GOC:bf]
synonym: "inhibition of host interferon receptors by virus" EXACT [UniProtKB-KW:KW-1091]
synonym: "negative regulation by virus of host interferon receptor activity" EXACT [GOC:bf]
xref: VZ:843 "Inhibition of host interferon receptors by virus"
is_a: GO:0039508 ! suppression by virus of host receptor activity
created_by: rfoulger
creation_date: 2011-06-16T02:24:05Z

[Term]
id: GO:0039512
name: suppression by virus of host protein tyrosine kinase activity
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host protein tyrosine kinase activity." [GOC:bf, GOC:sp]
subset: virus_checked
synonym: "down-regulation by virus of host protein tyrosine kinase activity" EXACT [GOC:bf]
synonym: "downregulation by virus of host protein tyrosine kinase activity" EXACT [GOC:bf]
synonym: "inhibition by virus of host protein tyrosine kinase activity" NARROW [GOC:bf]
synonym: "negative regulation by virus of host protein tyrosine kinase activity" EXACT [GOC:bf]
is_a: GO:0039584 ! suppression by virus of host protein kinase activity
is_a: GO:0061099 ! negative regulation of protein tyrosine kinase activity
created_by: rfoulger
creation_date: 2011-06-16T02:27:26Z

[Term]
id: GO:0039513
name: suppression by virus of host catalytic activity
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host enzyme activity." [GOC:bf]
subset: virus_checked
synonym: "down-regulation by virus of host enzyme activity" EXACT [GOC:bf]
synonym: "downregulation by virus of host catalytic activity" EXACT [GOC:bf]
synonym: "inhibition by virus of host catalytic activity" NARROW [GOC:bf]
synonym: "negative regulation by virus of host catalytic activity" EXACT [GOC:bf]
is_a: GO:0039507 ! suppression by virus of host molecular function
is_a: GO:0039516 ! modulation by virus of host catalytic activity
is_a: GO:0052053 ! negative regulation by symbiont of host catalytic activity
created_by: rfoulger
creation_date: 2011-06-16T02:32:49Z

[Term]
id: GO:0039514
name: suppression by virus of host JAK-STAT cascade
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the JAK-STAT signal cascade in the host organism." [GOC:bf, GOC:sp]
subset: virus_checked
synonym: "down-regulation by virus of host JAK-STAT cascade" EXACT [GOC:bf]
synonym: "downregulation by virus of host JAK-STAT cascade" EXACT [GOC:bf]
synonym: "inhibition by virus of host JAK-STAT cascade" NARROW [GOC:bf]
synonym: "negative regulation by virus of host JAK-STAT cascade" EXACT [GOC:bf]
is_a: GO:0019054 ! modulation by virus of host process
is_a: GO:0052029 ! negative regulation by symbiont of host signal transduction pathway
created_by: rfoulger
creation_date: 2011-06-16T02:48:03Z

[Term]
id: GO:0039516
name: modulation by virus of host catalytic activity
namespace: biological_process
def: "The process in which a virus effects a change in host enzyme activity." [GOC:bf, GOC:sp]
subset: goslim_virus
subset: virus_checked
synonym: "modulation of catalytic activity of host by virus" EXACT [GOC:bf]
synonym: "regulation by virus of host catalytic activity" EXACT [GOC:bf]
synonym: "regulation of host catalytic activity by virus" EXACT [GOC:bf]
is_a: GO:0039506 ! modulation by virus of host molecular function
is_a: GO:0052148 ! modulation by symbiont of host catalytic activity
created_by: rfoulger
creation_date: 2011-06-16T02:59:35Z

[Term]
id: GO:0039517
name: modulation by virus of host protein serine/threonine phosphatase activity
namespace: biological_process
def: "The process in which a virus effects a change in host protein serine/threonine phosphatase activity." [GOC:bf, GOC:sp]
subset: virus_checked
synonym: "modulation by virus of protein serine/threonine phosphatase activity in host" EXACT [GOC:bf]
synonym: "regulation by virus of host protein serine/threonine phosphatase activity" EXACT [GOC:bf]
is_a: GO:0039516 ! modulation by virus of host catalytic activity
is_a: GO:0080163 ! regulation of protein serine/threonine phosphatase activity
created_by: rfoulger
creation_date: 2011-06-16T03:04:14Z

[Term]
id: GO:0039518
name: suppression by virus of host cytokine activity
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host cytokine activity." [GOC:bf, GOC:sp]
subset: virus_checked
synonym: "down-regulation by virus of host cytokine activity" EXACT [GOC:bf]
synonym: "downregulation by virus of host cytokine activity" EXACT [GOC:bf]
synonym: "inhibition by virus of host cytokine activity" NARROW [GOC:bf]
synonym: "negative regulation by virus of host cytokine activity" EXACT [GOC:bf]
is_a: GO:0039507 ! suppression by virus of host molecular function
is_a: GO:0060302 ! negative regulation of cytokine activity
created_by: rfoulger
creation_date: 2011-06-22T04:09:41Z

[Term]
id: GO:0039519
name: modulation by virus of host autophagy
namespace: biological_process
def: "Any process in which a virus effect a change in the frequency, rate or extent of autophagy in the host." [GOC:bf, GOC:sp]
subset: goslim_virus
subset: virus_checked
synonym: "regulation by virus of host autophagy" EXACT [GOC:bf]
is_a: GO:0010506 ! regulation of autophagy
is_a: GO:0019054 ! modulation by virus of host process
created_by: rfoulger
creation_date: 2011-06-22T04:19:19Z

[Term]
id: GO:0039520
name: induction by virus of host autophagy
namespace: biological_process
def: "Any process in which a virus activates or increases the frequency, rate or extent of autophagy in the host." [GOC:bf, GOC:sp, UniProtKB-KW:KW-1072, VZ:846]
subset: virus_checked
synonym: "activation of host autophagy by virus" EXACT [UniProtKB-KW:KW-1072]
synonym: "positive regulation by virus of host autophagy" BROAD [GOC:bf]
xref: VZ:846 "Activation of host autophagy by virus"
is_a: GO:0010508 ! positive regulation of autophagy
is_a: GO:0039519 ! modulation by virus of host autophagy
created_by: rfoulger
creation_date: 2011-06-22T04:24:47Z

[Term]
id: GO:0039521
name: suppression by virus of host autophagy
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of autophagy in the host." [GOC:bf, GOC:sp, UniProtKB-KW:KW-1083, VZ:845]
subset: virus_checked
synonym: "inhibition by virus of host autophagy" EXACT [GOC:bf]
synonym: "inhibition of host autophagy by virus" EXACT [UniProtKB-KW:KW-1083]
synonym: "negative regulation by virus of host autophagy" BROAD [GOC:bf]
xref: VZ:845 "Inhibition of host autophagy by virus"
is_a: GO:0010507 ! negative regulation of autophagy
is_a: GO:0039519 ! modulation by virus of host autophagy
created_by: rfoulger
creation_date: 2011-06-22T04:30:11Z

[Term]
id: GO:0039522
name: suppression by virus of host mRNA export from nucleus
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of movement of mRNA from the nucleus to the cytoplasm in the host organism." [GOC:bf, GOC:sp, UniProtKB-KW:KW-1099, VZ:902]
subset: virus_checked
synonym: "inhibition by virus of host mRNA nuclear export" EXACT [GOC:bf]
synonym: "inhibition of host mRNA nuclear export by virus" EXACT [UniProtKB-KW:KW-1099]
synonym: "negative regulation by virus of host mRNA nuclear export" BROAD [GOC:bf]
synonym: "suppression of host mRNA nuclear export by virus" EXACT [GOC:bf]
xref: VZ:902 "Inhibition of host mRNA nuclear export by virus"
is_a: GO:0019054 ! modulation by virus of host process
is_a: GO:0052038 ! modulation by symbiont of host intracellular transport
created_by: rfoulger
creation_date: 2011-06-22T04:34:14Z

[Term]
id: GO:0039523
name: suppression by virus of host RNA polymerase II activity
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host RNA polymerase II activity." [GOC:bf, GOC:sp, UniProtKB-KW:KW-1104, VZ:905]
subset: virus_checked
synonym: "inhibition of host RNA polymerase II activity by virus" EXACT [GOC:bf]
synonym: "inhibition of host RNA polymerase II by virus" EXACT [UniProtKB-KW:KW-1104]
synonym: "negative regulation by virus of host RNA polymerase II activity" BROAD [GOC:bf]
xref: VZ:905 "Inhibition of host RNA polymerase II by virus"
is_a: GO:0039507 ! suppression by virus of host molecular function
is_a: GO:0039653 ! suppression by virus of host transcription
created_by: rfoulger
creation_date: 2011-06-22T04:38:59Z

[Term]
id: GO:0039524
name: suppression by virus of host mRNA processing
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of mRNA processing in the host cell. mRNA processing is the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:bf, GOC:sp, UniProtKB-KW:KW-1103, VZ:903]
subset: virus_checked
synonym: "inhibition by virus of host mRNA processing" EXACT [GOC:bf]
synonym: "inhibition of host mRNA processing by virus" EXACT [GOC:bf]
synonym: "inhibition of host pre-mRNA processing by virus" EXACT [UniProtKB-KW:KW-1103, VZ:903]
synonym: "negative regulation by virus of host mRNA processing" BROAD [GOC:bf]
xref: VZ:903 "Inhibition of host pre-mRNA processing by virus"
is_a: GO:0039657 ! suppression by virus of host gene expression
is_a: GO:0046778 ! modification by virus of host mRNA processing
is_a: GO:0050686 ! negative regulation of mRNA processing
created_by: rfoulger
creation_date: 2011-06-22T04:51:55Z

[Term]
id: GO:0039525
name: modulation by virus of host chromatin organization
namespace: biological_process
def: "Any process in which a virus effects a change in the organization of chromatin in the host." [GOC:bf, GOC:sp, UniProtKB-KW:KW-1122]
subset: virus_checked
synonym: "modulation by virus of host chromatin organisation" EXACT [GOC:mah]
synonym: "modulation of host chromatin by virus" EXACT [UniProtKB-KW:KW-1122]
synonym: "modulation of host chromatin structure by virus" EXACT [GOC:bf]
synonym: "regulation by virus of host chromatin organization" RELATED [GOC:bf]
is_a: GO:0019054 ! modulation by virus of host process
created_by: rfoulger
creation_date: 2011-06-22T05:11:13Z

[Term]
id: GO:0039526
name: modulation by virus of host apoptotic process
namespace: biological_process
def: "Any process in which a virus modulates the frequency, rate or extent of apoptosis of infected host cells." [GOC:bf, GOC:mtg_apoptosis, GOC:sp, UniProtKB-KW:KW-1119]
subset: goslim_virus
subset: virus_checked
synonym: "modulation by virus of host apoptosis" EXACT []
synonym: "modulation of host cell apoptosis by virus" EXACT [UniProtKB-KW:KW-1119]
synonym: "regulation by virus of host apoptosis" EXACT [GOC:bf]
xref: VZ:1581 "Apoptosis modulation"
is_a: GO:0019054 ! modulation by virus of host process
is_a: GO:0052150 ! modulation by symbiont of host apoptotic process
created_by: rfoulger
creation_date: 2011-06-22T05:22:53Z

[Term]
id: GO:0039527
name: suppression by virus of host TRAF-mediated signal transduction
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of TRAF-mediated signal transduction in the host." [GOC:bf, GOC:sp]
subset: virus_checked
synonym: "inhibition of host TRAF-mediated signal transduction by virus" EXACT [GOC:bf]
synonym: "negative regulation by virus of host TRAF-mediated signal transduction" BROAD [GOC:bf]
synonym: "suppression by virus of host tumor necrosis factor receptor-associated factor signaling" EXACT [GOC:bf]
is_a: GO:0019054 ! modulation by virus of host process
is_a: GO:0052029 ! negative regulation by symbiont of host signal transduction pathway
created_by: rfoulger
creation_date: 2011-06-22T05:30:41Z

[Term]
id: GO:0039528
name: cytoplasmic pattern recognition receptor signaling pathway in response to virus
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of a virus or viral RNA binding to a pattern recognition receptor (PRR) located in the cytoplasm. Cytosolic PRRs such as RIG-I (DDX58) and MDA-5 (IFIH1) detect RNA synthesized during active viral replication and trigger a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines." [GOC:bf, PMID:17328678, PMID:18272355, PMID:19531363]
comment: This term should be used for annotation when it is not known which cytoplasmic pattern recognition receptor (PRR) has detected the viral RNA. If the PRR is known, consider instead the child terms. The RIG-like family is composed of at least RIG-I (retinoic acid inducible gene I; also known as DDX58), melanoma differentiation-associated gene 5 (MDA5; also known as helicard or IFIH1) and LGP2.
synonym: "cytoplasmic caspase-recruiting domain (CARD) helicase signaling pathway" NARROW [PMID:17328678]
synonym: "cytoplasmic pattern recognition receptor signalling pathway in response to virus" EXACT [GOC:mah]
synonym: "RIG-I-like receptor (RLR) signaling pathway" NARROW [PMID:21626883]
synonym: "RIG-I/MDA5 signaling pathway" NARROW [PMID:21187438]
synonym: "RIG-like helicase signaling pathway" NARROW [PMID:18272355]
synonym: "RIG-like receptor signaling pathway" NARROW [PMID:19531363]
synonym: "RLH signaling pathway" NARROW [PMID:18272355]
synonym: "RLR signaling pathway" NARROW [PMID:19531363]
synonym: "virus-induced cytoplasmic pattern recognition receptor signaling pathway" EXACT [GOC:bf]
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0002753 ! cytoplasmic pattern recognition receptor signaling pathway
is_a: GO:0044764 ! multi-organism cellular process
is_a: GO:0098586 ! cellular response to virus
intersection_of: GO:0002753 ! cytoplasmic pattern recognition receptor signaling pathway
intersection_of: part_of GO:0051607 ! defense response to virus
relationship: part_of GO:0051607 ! defense response to virus
created_by: rfoulger
creation_date: 2011-12-20T02:43:15Z

[Term]
id: GO:0039529
name: RIG-I signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) RIG-1 (also known as DDX58) binding to viral RNA. RIG-I detects RNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines." [GOC:bf, PMID:17328678, PMID:19620789, PMID:21435580]
comment: The apoptosis effect triggered by the RIG-I signaling pathway is inconclusive and may represent an in-vitro phenomenon. Therefore, in GO the term 'RIG-I signaling pathway ; GO:0039529' is positioned under 'regulation of cytokine production' as this is its primary effect.
subset: virus_checked
synonym: "DDX58 signaling pathway" EXACT [HGNC:19102]
synonym: "retinoic acid inducible gene I signaling pathway" EXACT [HGNC:19102]
synonym: "RIG-I signalling pathway" EXACT [GOC:mah]
is_a: GO:0039528 ! cytoplasmic pattern recognition receptor signaling pathway in response to virus
created_by: rfoulger
creation_date: 2011-12-20T03:11:06Z

[Term]
id: GO:0039530
name: MDA-5 signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1) binding to viral RNA. MDA-5 detects RNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines." [GOC:bf, PMID:19620789]
subset: virus_checked
synonym: "IFIH1 signaling pathway" EXACT [HGNC:18873]
synonym: "MDA-5 signalling pathway" EXACT [GOC:mah]
synonym: "MDA5 signaling pathway" NARROW [PMID:17328678]
synonym: "melanoma differentiation-associated gene 5 signaling pathway" EXACT [HGNC:18873]
is_a: GO:0039528 ! cytoplasmic pattern recognition receptor signaling pathway in response to virus
created_by: rfoulger
creation_date: 2011-12-20T03:14:52Z

[Term]
id: GO:0039531
name: regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the series of molecular signals generated as a consequence of a virus or viral RNA binding to a pattern recognition receptor (PRR) located in the cytoplasm." [GOC:bf, GOC:jl]
subset: virus_checked
synonym: "regulation of MAV signaling" RELATED [GOC:bf, GOC:sp]
synonym: "regulation of viral-induced cytoplasmic pattern recognition receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0001817 ! regulation of cytokine production
is_a: GO:0045088 ! regulation of innate immune response
is_a: GO:0050688 ! regulation of defense response to virus
is_a: GO:1902531 ! regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0039528 ! cytoplasmic pattern recognition receptor signaling pathway in response to virus
relationship: regulates GO:0039528 ! cytoplasmic pattern recognition receptor signaling pathway in response to virus
created_by: rfoulger
creation_date: 2012-01-03T11:06:56Z

[Term]
id: GO:0039532
name: negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals generated as a consequence of a virus or viral RNA binding to a pattern recognition receptor (PRR) located in the cytoplasm." [GOC:bf, GOC:jl]
subset: virus_checked
synonym: "negative regulation of cytoplasmic pattern recognition receptor signaling pathway in response to virus" EXACT [GOC:bf]
synonym: "negative regulation of MAVS signaling" RELATED [GOC:bf]
synonym: "negative regulation of viral-induced cytoplasmic pattern recognition receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0039531 ! regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway
is_a: GO:0050687 ! negative regulation of defense response to virus
is_a: GO:1902532 ! negative regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0039528 ! cytoplasmic pattern recognition receptor signaling pathway in response to virus
relationship: negatively_regulates GO:0039528 ! cytoplasmic pattern recognition receptor signaling pathway in response to virus
created_by: rfoulger
creation_date: 2012-01-03T11:14:48Z

[Term]
id: GO:0039533
name: regulation of MDA-5 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1) binding to viral RNA." [GOC:bf, GOC:jl]
subset: virus_checked
synonym: "regulation of IFIH1 signaling pathway" EXACT [HGNC:18873]
synonym: "regulation of MDA-5 signalling pathway" EXACT [GOC:mah]
synonym: "regulation of MDA5 signaling pathway" EXACT [PMID:17328678]
synonym: "regulation of melanoma differentiation-associated gene 5 signaling pathway" EXACT [HGNC:18873]
is_a: GO:0039531 ! regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0039530 ! MDA-5 signaling pathway
relationship: regulates GO:0039530 ! MDA-5 signaling pathway
created_by: rfoulger
creation_date: 2012-01-03T11:17:31Z

[Term]
id: GO:0039534
name: negative regulation of MDA-5 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1) binding to viral RNA." [GOC:bf, GOC:jl]
subset: virus_checked
synonym: "negative regulation of IFIH1 signaling pathway" EXACT [HGNC:18873]
synonym: "negative regulation of MDA-5 signalling pathway" EXACT [GOC:mah]
synonym: "negative regulation of MDA5 signaling pathway" EXACT [PMID:17328678]
synonym: "negative regulation of melanoma differentiation-associated gene 5 signaling pathway" EXACT [HGNC:18873]
is_a: GO:0039532 ! negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway
is_a: GO:0039533 ! regulation of MDA-5 signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0039530 ! MDA-5 signaling pathway
relationship: negatively_regulates GO:0039530 ! MDA-5 signaling pathway
created_by: rfoulger
creation_date: 2012-01-03T11:21:20Z

[Term]
id: GO:0039535
name: regulation of RIG-I signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) RIG-1 (also known as DDX58) binding to viral RNA." [GOC:bf, GOC:jl]
subset: virus_checked
synonym: "regulation of DDX58 signaling pathway" EXACT [HGNC:19102]
synonym: "regulation of retinoic acid inducible gene I signaling pathway" EXACT [HGNC:19102]
synonym: "regulation of RIG-I signalling pathway" EXACT [GOC:mah]
is_a: GO:0039531 ! regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0039529 ! RIG-I signaling pathway
relationship: regulates GO:0039529 ! RIG-I signaling pathway
created_by: rfoulger
creation_date: 2012-01-03T11:24:29Z

[Term]
id: GO:0039536
name: negative regulation of RIG-I signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) RIG-1 (also known as DDX58) binding to viral RNA." [GOC:bf, GOC:jl]
subset: virus_checked
synonym: "negative regulation of DDX58 signaling pathway" EXACT [HGNC:19102]
synonym: "negative regulation of retinoic acid inducible gene I signaling pathway" EXACT [HGNC:19102]
synonym: "negative regulation of RIG-I signalling pathway" EXACT [GOC:mah]
is_a: GO:0039532 ! negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway
is_a: GO:0039535 ! regulation of RIG-I signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0039529 ! RIG-I signaling pathway
relationship: negatively_regulates GO:0039529 ! RIG-I signaling pathway
created_by: rfoulger
creation_date: 2012-01-03T11:27:51Z

[Term]
id: GO:0039537
name: suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals generated as a consequence of a virus or viral RNA binding to a pattern recognition receptor (PRR) located in the cytoplasm. This is a mechanism by which the virus evades the host innate immune response." [GOC:bf, GOC:jl]
subset: virus_checked
synonym: "suppression by virus of host cytoplasmic pattern recognition receptor signaling pathway in response to virus" EXACT [GOC:bf]
synonym: "suppression by virus of host RIG-I-like receptor (RLR) signaling pathway" RELATED [GOC:bf]
synonym: "suppression by virus of host RIG-I/MDA5 signaling pathway" RELATED [GOC:bf]
synonym: "suppression by virus of host RIG-like helicase signaling pathway" RELATED [GOC:bf]
synonym: "suppression by virus of host RIG-like receptor signaling pathway" RELATED [GOC:bf]
synonym: "suppression by virus of host RLR signaling pathway" RELATED [GOC:bf]
synonym: "suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0039503 ! suppression by virus of host innate immune response
is_a: GO:0039532 ! negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway
is_a: GO:0044831 ! modulation by virus of host cytokine production
is_a: GO:0075111 ! negative regulation by symbiont of host receptor-mediated signal transduction
intersection_of: GO:0019054 ! modulation by virus of host process
intersection_of: negatively_regulates GO:0039528 ! cytoplasmic pattern recognition receptor signaling pathway in response to virus
relationship: negatively_regulates GO:0039528 ! cytoplasmic pattern recognition receptor signaling pathway in response to virus
created_by: rfoulger
creation_date: 2012-01-03T11:47:05Z

[Term]
id: GO:0039538
name: suppression by virus of host RIG-I signaling pathway
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) RIG-1 (also known as DDX58) binding to viral RNA. This is a mechanism by which the virus evades the host innate immune response." [GOC:bf, GOC:jl]
subset: virus_checked
synonym: "inhibition by virus of host RIG-I signaling" EXACT [GOC:bf]
synonym: "suppression by virus of host DDX58 signaling pathway" EXACT [GOC:bf]
synonym: "suppression by virus of host RIG-I signalling pathway" EXACT [GOC:mah]
is_a: GO:0039536 ! negative regulation of RIG-I signaling pathway
is_a: GO:0039537 ! suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway
intersection_of: GO:0019054 ! modulation by virus of host process
intersection_of: negatively_regulates GO:0039529 ! RIG-I signaling pathway
relationship: negatively_regulates GO:0039529 ! RIG-I signaling pathway
created_by: rfoulger
creation_date: 2012-01-03T11:50:17Z

[Term]
id: GO:0039539
name: suppression by virus of host MDA-5 signaling pathway
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1) binding to viral RNA. This is a mechanism by which the virus evades the host innate immune response." [GOC:bf, GOC:jl]
subset: virus_checked
synonym: "inhibition by virus of host MDA-5 signaling" EXACT [GOC:bf]
synonym: "suppression by virus of host IFIH1 signaling pathway" EXACT [GOC:bf]
synonym: "suppression by virus of host MDA-5 signalling pathway" EXACT [GOC:mah]
is_a: GO:0039534 ! negative regulation of MDA-5 signaling pathway
is_a: GO:0039537 ! suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway
intersection_of: GO:0019054 ! modulation by virus of host process
intersection_of: negatively_regulates GO:0039530 ! MDA-5 signaling pathway
relationship: negatively_regulates GO:0039530 ! MDA-5 signaling pathway
created_by: rfoulger
creation_date: 2012-01-03T11:51:36Z

[Term]
id: GO:0039540
name: suppression by virus of host RIG-I activity
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the activity of RIG-1 (also known as DDX58). The cytoplasmic pattern recognition RIG-I recognizes viral RNA synthesized during active viral replication and signals to protect the host against viral infection, for example by inducing the expression of antiviral cytokines." [GOC:bf, GOC:sp, UniProtKB-KW:KW-1088, VZ:856]
comment: This term is for annotation of viral proteins that counteract the host anti-viral innate immune response initiated by host RIG-I, either by binding and inhibiting host RIG-I directly, or by interfering with other processes so that RIG-I is unable to carry out its normal function (e.g. by processing viral RNA so it cannot be recognized by RIG-I, or by promoting the degradation of RIG-I).
subset: virus_checked
synonym: "inhibition by virus of host DDX58 activity" EXACT [GOC:sp]
synonym: "inhibition by virus of host RIG-I" RELATED [GOC:bf]
synonym: "inhibition of host DDX58/RIG-I by virus" EXACT [UniProtKB-KW:KW-1088]
xref: VZ:856 "Inhibition of host RIG-I by virus"
is_a: GO:0039509 ! suppression by virus of host pattern recognition receptor activity
is_a: GO:0039538 ! suppression by virus of host RIG-I signaling pathway
created_by: rfoulger
creation_date: 2012-01-18T02:24:20Z

[Term]
id: GO:0039541
name: suppression by virus of host RIG-I via RIG-I binding
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the activity of RIG-I (also known as DDX58) by interacting selectively and non-covalently with RIG-I itself." [PMID:19193793, PMID:20007272, VZ:856]
comment: This term is for annotation of viral proteins that counteract the host anti-viral innate immune response. Direct binding of viral proteins to the host RIG-I protein can inhibit interaction of RIG-I with its downstream effector MAVS.
subset: virus_checked
synonym: "inhibition by virus of host DDX58:MAVS binding" EXACT [GOC:bf]
is_a: GO:0039540 ! suppression by virus of host RIG-I activity
relationship: has_part GO:0039552 ! RIG-I binding
created_by: rfoulger
creation_date: 2012-01-19T02:14:20Z

[Term]
id: GO:0039542
name: suppression by virus of host RIG-I K63-linked ubiquitination
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the rate or extent of K63-linked ubiquitination of RIG-I (also known as DDX58), thereby suppressing RIG-I signal transduction. Lys63-linked ubiquitination of the N-terminal CARD domains of RIG-I is crucial for the cytosolic RIG-I signaling pathway to elicit host antiviral innate immunity." [PMID:19454348, PMID:21890623]
comment: This term is for annotation of viral proteins that counteract the host anti-viral innate immune response.
subset: virus_checked
synonym: "inhibition by virus of host DDX58 K63-linked ubiquitination" EXACT [GOC:bf]
synonym: "inhibition by virus of host RIG-I activity by inhibition of RIG-I ubiquitination" BROAD [GOC:bf]
synonym: "inhibition by virus of TRIM25-mediated ubiquitination of host RIG-I" EXACT [PMID:19454348]
is_a: GO:0039540 ! suppression by virus of host RIG-I activity
is_a: GO:1900045 ! negative regulation of protein K63-linked ubiquitination
created_by: rfoulger
creation_date: 2012-01-18T02:30:29Z

[Term]
id: GO:0039543
name: suppression by virus of host RIG-I activity by viral RNA 5' processing
namespace: biological_process
def: "The post-transcriptional removal by a virus of the 5' triphosphate group of their viral RNA, thereby preventing host RIG-I from recognizing viral RNA in the host cell. The intracellular pattern recognition receptor RIG-I (also known as DDX58) recognizes viral RNAs containing 5' triphosphates; removal by the virus of the 5'-terminal triphosphate group from their genome protects the viral RNA from RIG-recognition." [PMID:18446221, VZ:856]
comment: This term is for annotation of viral proteins that counteract the host anti-viral innate immune response.
subset: virus_checked
synonym: "suppression by virus of host RIG-I activity by inhibition of RNA binding" NARROW [GOC:bf]
is_a: GO:0039540 ! suppression by virus of host RIG-I activity
created_by: rfoulger
creation_date: 2012-01-18T02:30:29Z

[Term]
id: GO:0039544
name: suppression by virus of host RIG-I activity by RIG-I proteolysis
namespace: biological_process
def: "The chemical reactions and pathways performed by a virus resulting in the hydrolysis of the host RIG-I protein (also known as DDX58) by cleavage of peptide bonds, thereby inhibiting RIG-I signal transduction." [PMID:19628239]
comment: This term is for annotation of viral proteins that counteract the host anti-viral innate immune response.
subset: virus_checked
synonym: "cleavage of RIG-I by viral proteinase" EXACT [PMID:19628239]
synonym: "inhibition by virus of host RIG-I activity by RIG-I proteolysis" RELATED [VZ:856]
is_a: GO:0035897 ! proteolysis in other organism
is_a: GO:0039540 ! suppression by virus of host RIG-I activity
created_by: rfoulger
creation_date: 2012-01-18T02:30:29Z

[Term]
id: GO:0039545
name: suppression by virus of host MAVS activity
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the activity of MAVS (mitochondrial antiviral signaling protein), a signal transducer that lies downstream of the viral RNA receptors MDA-5 and RIG-I to coordinate host innate immune responses." [UniProtKB-KW:KW-1097, VZ:704]
comment: This term is for annotation of viral proteins that counteract the host anti-viral innate immune response.
subset: virus_checked
synonym: "inhibition of host MAVS by virus" EXACT [UniProtKB-KW:KW-1097, VZ:704]
synonym: "suppression by virus of host mitochondrial antiviral-signaling protein" EXACT [PR:000010210]
xref: VZ:704 "Inhibition of host MAVS by virus"
is_a: GO:0039507 ! suppression by virus of host molecular function
is_a: GO:0039537 ! suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway
created_by: rfoulger
creation_date: 2012-01-19T02:37:20Z

[Term]
id: GO:0039546
name: suppression by virus of host MAVS activity by MAVS proteolysis
namespace: biological_process
def: "The chemical reactions and pathways performed by a virus resulting in the hydrolysis of the host MAVS (mitochondrial inhibitor of viral signaling) protein by cleavage of peptide bonds, thereby inhibiting the host innate immune response. For example, MAVS harbors a C-terminal transmembrane domain that targets it to the mitochondrial outer membrane; cleavage within this domain removes MAVS from the membrane, thus preventing it from signaling." [PMID:21436888, PMID:22238314]
comment: This term is for annotation of viral proteins that counteract the host anti-viral innate immune response.
subset: virus_checked
synonym: "viral protease cleavage of MAVS" EXACT [PMID:22238314]
is_a: GO:0035897 ! proteolysis in other organism
is_a: GO:0039545 ! suppression by virus of host MAVS activity
created_by: rfoulger
creation_date: 2012-01-19T02:49:44Z

[Term]
id: GO:0039547
name: suppression by virus of host TRAF activity
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the activity of a host TRAF (tumor necrosis factor receptor-associated factor) protein. TRAFs are intracellular signal transducers that lie downstream of receptors including RIG-I, MDA-5 and Toll-like receptors (TLR) and transfer the signal to other intracellular signaling components." [GOC:bf, UniProtKB-KW:KW-1110, VZ:715]
comment: This term is for annotation of viral proteins that counteract the host anti-viral innate immune response.
subset: virus_checked
synonym: "inhibition of host TRAFs by virus" EXACT [UniProtKB-KW:KW-1110]
is_a: GO:0039507 ! suppression by virus of host molecular function
relationship: part_of GO:0039527 ! suppression by virus of host TRAF-mediated signal transduction
created_by: rfoulger
creation_date: 2012-01-19T03:12:15Z

[Term]
id: GO:0039548
name: suppression by virus of host IRF3 activity
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the activity of host IRF3 (interferon regulatory factor-3), a transcription factor in the RIG-I/MDA-5 signaling pathway. Viral infection triggers phosphorylation of cytoplasmic IRF3, which allows IRF3 to form a homodimer, migrate to the nucleus, and activate transcription of IFN-alpha and IFN-beta genes." [PMID:21632562, UniProtKB-KW:KW-1092, VZ:757]
comment: This term is for annotation of viral proteins that counteract the host anti-viral innate immune response.
subset: virus_checked
synonym: "inhibition of host IRF3 by virus" EXACT [UniProtKB-KW:KW-1092]
synonym: "Inhibition of IRF3-dependent antiviral response" BROAD [PMID:19125153]
synonym: "suppression by virus of host interferon regulatory factor 3" EXACT [PR:000002045]
xref: VZ:757 "Inhibition of host IRF3 by virus"
is_a: GO:0039503 ! suppression by virus of host innate immune response
is_a: GO:0039507 ! suppression by virus of host molecular function
is_a: GO:0039653 ! suppression by virus of host transcription
created_by: rfoulger
creation_date: 2012-01-19T04:04:26Z

[Term]
id: GO:0039549
name: suppression by virus of host IRF3 activity by inhibition of IRF3 phosphorylation
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the rate or extent of the phosphorylation of IRF3 (interferon regulatory factor-3), thereby inhibiting IRF3 activation. In response to signaling from RIG-1/MDA-5 receptors, IRF3 is phosphorylated on multiple serine and threonine residues; phosphorylation results in the cytoplasm-to-nucleus translocation of IRF3, DNA binding, and increased transcriptional activation of interferon-encoding genes." [PMID:11124948, PMID:12829834, PMID:20631144, PMID:9566918]
comment: This term is for annotation of viral proteins that counteract the host anti-viral innate immune response.
subset: virus_checked
synonym: "inhibition of phosphorylation-induced activation of host IRF3" RELATED [PMID:11124948]
synonym: "inhibition of virus-induced IRF-3 phosphorylation" BROAD [PMID:12829834]
is_a: GO:0039548 ! suppression by virus of host IRF3 activity
is_a: GO:0039613 ! suppression by virus of host protein phosphorylation
created_by: rfoulger
creation_date: 2012-01-19T04:27:06Z

[Term]
id: GO:0039550
name: suppression by virus of host IRF3 activity by inhibition of DNA binding
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces IRF3-dependent gene transcription, by preventing or reducing IRF3 binding to promoter sites." [PMID:21632562]
comment: This term is for annotation of viral proteins that counteract the host anti-viral innate immune response.
subset: virus_checked
synonym: "inhibition by virus of host IRF3-DNA binding" EXACT [GOC:bf]
is_a: GO:0039548 ! suppression by virus of host IRF3 activity
is_a: GO:0043392 ! negative regulation of DNA binding
created_by: rfoulger
creation_date: 2012-01-19T04:27:25Z

[Term]
id: GO:0039551
name: suppression by virus of host IRF3 activity by positive regulation of IRF3 catabolic process
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the activity of host IRF3 (interferon regulatory factor-3) by promoting the ubiquitin-dependent degradation of IRF3, mediated by the proteasome." [VZ:757]
comment: This term is for annotation of viral proteins that counteract the host anti-viral innate immune response.
subset: virus_checked
synonym: "promotion by virus of proteosome-dependent IRF3 degradation" EXACT [VZ:757]
is_a: GO:0032436 ! positive regulation of proteasomal ubiquitin-dependent protein catabolic process
is_a: GO:0039548 ! suppression by virus of host IRF3 activity
created_by: rfoulger
creation_date: 2012-01-20T11:35:33Z

[Term]
id: GO:0039552
name: RIG-I binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with RIG-I, a cytosolic pattern recognition receptor that initiates an antiviral signaling pathway upon binding to viral RNA." [GOC:bf, PMID:21233210]
subset: virus_checked
synonym: "DDX58 binding" EXACT [GOC:sp]
synonym: "DDX58/RIG-I binding" EXACT [GOC:sp]
is_a: GO:0005102 ! receptor binding
created_by: rfoulger
creation_date: 2012-01-19T02:14:20Z

[Term]
id: GO:0039553
name: suppression by virus of host chemokine activity
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host chemokine activity." [GOC:bf, GOC:sp, UniProtKB-KW:KW-1086, VZ:813]
subset: virus_checked
synonym: "down-regulation by virus of host chemokine activity" EXACT [GOC:bf]
synonym: "downregulation by virus of host chemokine activity" EXACT [GOC:bf]
synonym: "inhibition by virus of host chemokine activity" NARROW [GOC:bf]
synonym: "inhibition of host chemokines by virus" NARROW [UniProtKB-KW:KW-1086]
synonym: "negative regulation by virus of host chemokine activity" EXACT [GOC:bf]
xref: VZ:813 "Inhibition of host chemokines by virus"
is_a: GO:0039518 ! suppression by virus of host cytokine activity
is_a: GO:1900137 ! negative regulation of chemokine activity
created_by: rfoulger
creation_date: 2012-02-28T01:29:55Z

[Term]
id: GO:0039554
name: suppression by virus of host MDA-5 activity
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the activity of MDA-5 (also known as IFIH1). The cytoplasmic pattern recognition receptor MDA-5 detects dsRNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines." [UniProtKB-KW:KW-1089, VZ:603]
subset: virus_checked
synonym: "inhibition of host IFIH1/MDA5 by virus" RELATED [UniProtKB-KW:KW-1089]
synonym: "Inhibition of host MDA5 by virus" EXACT [VZ:603]
xref: VZ:603 "Inhibition of host MDA5 by virus"
is_a: GO:0039509 ! suppression by virus of host pattern recognition receptor activity
is_a: GO:0039539 ! suppression by virus of host MDA-5 signaling pathway
created_by: rfoulger
creation_date: 2012-03-09T03:03:49Z

[Term]
id: GO:0039555
name: suppression by virus of host MDA-5 activity via MDA-5 binding
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the activity of MDA-5 (also known as IFIH1) by interacting selectively and non-covalently with MDA-5 itself. For example, direct binding of viral proteins to the host MDA-5 protein can inhibit interaction of MDA-5 with MAVS, its downstream signaling effector." [PMID:19019954, VZ:603]
comment: This term is for annotation of viral proteins that counteract the host anti-viral innate immune response.
subset: virus_checked
synonym: "suppression by virus of host MDA5 activity by MDA-5 binding" EXACT [GOC:bf]
is_a: GO:0039554 ! suppression by virus of host MDA-5 activity
relationship: has_part GO:0039556 ! MDA-5 binding
created_by: rfoulger
creation_date: 2012-03-09T04:06:46Z

[Term]
id: GO:0039556
name: MDA-5 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with MDA-5, a cytosolic pattern recognition receptor that initiates an antiviral signaling pathway upon binding to viral dsRNA." [PMID:19019954]
subset: virus_checked
synonym: "MDA5 binding" EXACT [GOC:bf]
is_a: GO:0005102 ! receptor binding
created_by: rfoulger
creation_date: 2012-03-09T04:12:33Z

[Term]
id: GO:0039557
name: suppression by virus of host IRF7 activity
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the activity of host IRF7 (interferon regulatory factor-7), a transcription factor in the RIG-I/MDA-5 signaling pathway. Viral infection triggers phosphorylation of cytoplasmic IRF7, which allows IRF7 to form a homodimer, migrate to the nucleus, and activate transcription of IFN-alpha and IFN-beta genes." [UniProtKB-KW:KW-1093, VZ:653]
comment: This term is for annotation of viral proteins that counteract the host anti-viral innate immune response.
subset: virus_checked
synonym: "inhibition of host interferon regulatory factor-7 by virus" EXACT [VZ:653]
synonym: "inhibition of host IRF7 by virus" EXACT [UniProtKB-KW:KW-1093]
synonym: "suppression by virus of host interferon regulatory factor 7 activity" EXACT [PR:000002049]
xref: VZ:653 "Inhibition of host IRF7 by virus"
is_a: GO:0039503 ! suppression by virus of host innate immune response
is_a: GO:0039507 ! suppression by virus of host molecular function
is_a: GO:0039653 ! suppression by virus of host transcription
created_by: rfoulger
creation_date: 2012-03-09T04:17:46Z

[Term]
id: GO:0039558
name: suppression by virus of host IRF7 activity by positive regulation of IRF7 sumoylation
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces IRF7-dependent gene transcription, by promoting the sumoylation of IRF7, thereby disabling its activity." [PMID:18635538, PMID:19694547, VZ:653]
comment: This term is for annotation of viral proteins that counteract the host anti-viral innate immune response.
subset: virus_checked
synonym: "promotion of IRF-7 SUMOylation" EXACT [PMID:19694547]
synonym: "suppression by virus of host interferon regulatory factor-7 activity by positive regulation of IRF7 sumoylation" RELATED [GOC:bf]
is_a: GO:0033235 ! positive regulation of protein sumoylation
is_a: GO:0039557 ! suppression by virus of host IRF7 activity
created_by: rfoulger
creation_date: 2012-03-09T04:27:57Z

[Term]
id: GO:0039559
name: suppression by virus of host IRF7 activity by positive regulation of IRF7 catabolic process
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the activity of host IRF7 (interferon regulatory factor-7) by promoting the ubiquitin-dependent degradation of IRF7, mediated by the proteasome." [PMID:17301153, VZ:653]
comment: This term is for annotation of viral proteins that counteract the host anti-viral innate immune response.
subset: virus_checked
synonym: "promotion by virus of proteosome-dependent IRF7 degradation" EXACT [VZ:653]
is_a: GO:0032436 ! positive regulation of proteasomal ubiquitin-dependent protein catabolic process
is_a: GO:0039557 ! suppression by virus of host IRF7 activity
created_by: rfoulger
creation_date: 2012-03-09T04:38:58Z

[Term]
id: GO:0039560
name: suppression by virus of host IRF9 activity
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the activity of host IRF9 (interferon regulatory factor-9), a transcription factor involved in the innate immune response. Viral infection triggers binding of IRF9 to phosphorylated STAT1 and STAT2, forming the ISGF3 complex. The ISGF3 complex migrates to the nucleus and activates transcription of IFN-responsive genes." [UniProtKB-KW:KW-1094, VZ:683]
comment: This term is for annotation of viral proteins that counteract the host anti-viral innate immune response.
subset: virus_checked
synonym: "inhibition of host interferon regulatory factor-9 by virus" EXACT [GOC:bf]
synonym: "inhibition of host IRF9 by virus" EXACT [UniProtKB-KW:KW-1094]
synonym: "suppression by virus of host interferon regulatory factor 9 activity" EXACT [PR:000002051]
xref: VZ:683 "Inhibition of host IRF9 by virus"
is_a: GO:0039503 ! suppression by virus of host innate immune response
is_a: GO:0039507 ! suppression by virus of host molecular function
is_a: GO:0039653 ! suppression by virus of host transcription
created_by: rfoulger
creation_date: 2012-03-09T04:42:08Z

[Term]
id: GO:0039561
name: suppression by virus of host IRF9 activity by positive regulation of IRF9 localization to nucleus
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the activity of host IRF9 (interferon regulatory factor-9) by promoting the nuclear accumulation of IRF9. For example, the reovirus mu2 protein promotes nuclear accumulation of host IRF9 by an as yet unconfirmed-mechanism." [PMID:19109390]
comment: This term is for annotation of viral proteins that counteract the host anti-viral innate immune response.
subset: virus_checked
synonym: "suppression by virus of host IRF9 activity by nuclear localization of IRF9" RELATED [PMID:19109390]
synonym: "suppression of interferon signaling by nuclear accumulation of IRF9" RELATED [PMID:19109390]
is_a: GO:0039560 ! suppression by virus of host IRF9 activity
is_a: GO:1900182 ! positive regulation of protein localization to nucleus
created_by: rfoulger
creation_date: 2012-03-09T04:53:44Z

[Term]
id: GO:0039562
name: suppression by virus of host STAT activity
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT (signal transducer and activator of transcription) activity. STATs are SH2 domain-containing proteins which lie downstream of many signaling receptors. Upon phosphorylation by JAKs, STAT proteins hetero- or homo-dimerize and translocate to the nucleus to activate transcription of target genes." [GOC:bf]
comment: This term is for annotation of viral proteins that counteract the host anti-viral innate immune response.
subset: virus_checked
synonym: "inhibition by virus of host STAT activity" NARROW [GOC:bf]
synonym: "suppression by virus of host signal transducer and activator of transcription activity" EXACT [GOC:bf]
is_a: GO:0039507 ! suppression by virus of host molecular function
is_a: GO:0039514 ! suppression by virus of host JAK-STAT cascade
created_by: rfoulger
creation_date: 2012-03-12T02:28:39Z

[Term]
id: GO:0039563
name: suppression by virus of host STAT1 activity
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT1 (signal transducer and activator of transcription-1) activity. STATs are SH2 domain-containing proteins which lie downstream of many signaling receptors. Upon phosphorylation by JAKs, STAT proteins hetero- or homo-dimerize and translocate to the nucleus to activate transcription of target genes." [UniProtKB-KW:KW-1105, VZ:282]
comment: This term is for annotation of viral proteins that counteract the host anti-viral innate immune response.
subset: virus_checked
synonym: "inhibition by virus of host STAT1 activity" NARROW [GOC:bf]
synonym: "Inhibition of host STAT1 by virus" NARROW [VZ:282]
xref: VZ:282 "Inhibition of host STAT1 by virus"
is_a: GO:0039562 ! suppression by virus of host STAT activity
created_by: rfoulger
creation_date: 2012-03-12T02:35:39Z

[Term]
id: GO:0039564
name: suppression by virus of host STAT2 activity
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT2 (signal transducer and activator of transcription-2) activity. STATs are SH2 domain-containing proteins which lie downstream of many signaling receptors. Upon phosphorylation by JAKs, STAT proteins hetero- or homo-dimerize and translocate to the nucleus to activate transcription of target genes." [UniProtKB-KW:KW-1106, VZ:257]
subset: virus_checked
synonym: "inhibition by virus of host STAT2 activity" NARROW [GOC:bf]
synonym: "Inhibition of host STAT2 by virus" EXACT [VZ:257]
xref: VZ:257 "Inhibition of host STAT2 by virus"
is_a: GO:0039562 ! suppression by virus of host STAT activity
created_by: rfoulger
creation_date: 2012-03-12T02:52:34Z

[Term]
id: GO:0039565
name: suppression by virus of host STAT1 activity by positive regulation of STAT1 catabolic process
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the activity of host STAT1 (signal transducer and activator of transcription-1) by promoting the ubiquitin-dependent degradation of STAT1, mediated by the proteasome." [PMID:15280488, PMID:16227264, VZ:282]
comment: This term is for annotation of viral proteins that counteract the host anti-viral innate immune response. The Sendai virus protein C binds STAT1 directly to induce its degradation, whereas the V protein of simian virus 5 targets STAT1 for degradation by acting as an adaptor, without binding to STAT1.
subset: virus_checked
synonym: "promotion by virus of proteosome-dependent STAT1 degradation" EXACT []
synonym: "suppression by virus of host STAT1 activity by positive promotion of STAT1 proteasome-mediated degradation" EXACT [GOC:bf]
synonym: "targeting STAT1 for proteasome-mediated degradation" EXACT [VZ:282]
is_a: GO:0032436 ! positive regulation of proteasomal ubiquitin-dependent protein catabolic process
is_a: GO:0039563 ! suppression by virus of host STAT1 activity
created_by: rfoulger
creation_date: 2012-03-12T02:57:36Z

[Term]
id: GO:0039566
name: suppression by virus of host STAT1 activity by tyrosine dephosphorylation of STAT1
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT1 (signal transducer and activator of transcription-1) activity by the removal of phosphoric residues from STAT1-O-phospho-tyrosine to form STAT1-tyrosine. For example, the viral phosphatase VH1 dephosphorylates STAT1 to reverse STAT1 activation." [PMID:11238845, PMID:21362620, VZ:282]
comment: This term is for annotation of viral proteins that counteract the host anti-viral innate immune response.
subset: virus_checked
synonym: "suppression by virus of host STAT1 activity by peptidyl-tyrosine dephosphorylation of STAT1" EXACT [GOC:bf]
synonym: "viral tyrosine phosphatase activity involved in suppression of host STAT1" RELATED [GOC:bf]
is_a: GO:0036210 ! protein modification process in other organism
is_a: GO:0039563 ! suppression by virus of host STAT1 activity
created_by: rfoulger
creation_date: 2012-03-12T04:08:32Z

[Term]
id: GO:0039567
name: suppression by virus of host STAT1 activity by negative regulation of STAT protein import into nucleus
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT1 (signal transducer and activator of transcription-1) activity by retaining STAT1 in the cytoplasm, so STAT1 is unable to translocate to the nucleus to activate transcription of its target genes." [PMID:14557668, PMID:16254375, PMID:17287281]
subset: virus_checked
synonym: "cytoplasmic sequestration of STAT1" BROAD [PMID:14557668]
synonym: "suppression by virus of host STAT1 activity by cytoplasmic sequestering of STAT1" EXACT [PMID:14557668]
is_a: GO:0039563 ! suppression by virus of host STAT1 activity
is_a: GO:0044833 ! modulation by virus of host protein transport
is_a: GO:1903652 ! modulation by virus of host cytoplasmic transport
is_a: GO:1990215 ! negative regulation by symbiont of host intracellular transport
is_a: GO:2000365 ! negative regulation of STAT protein import into nucleus
created_by: rfoulger
creation_date: 2012-03-12T04:24:36Z

[Term]
id: GO:0039568
name: suppression by virus of host STAT1 activity by inhibition of DNA binding
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces STAT1-dependent gene transcription, by preventing STAT1 from binding to promoter sites in the nucleus." [PMID:17287281]
subset: virus_checked
synonym: "inhibition of DNA binding of STAT1" EXACT [PMID:17287281]
synonym: "suppression by virus of host STAT1 activity by negative regulation of DNA binding" EXACT [GOC:bf]
is_a: GO:0039563 ! suppression by virus of host STAT1 activity
is_a: GO:0043392 ! negative regulation of DNA binding
created_by: rfoulger
creation_date: 2012-03-12T04:31:58Z

[Term]
id: GO:0039569
name: suppression by virus of host STAT2 activity by positive regulation of STAT2 catabolic process
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the activity of host STAT2 (signal transducer and activator of transcription-2) by promoting the ubiquitin-dependent degradation of STAT2, mediated by the proteasome." [PMID:11336548, PMID:17251292, PMID:19279106, VZ:257]
comment: This term is for annotation of viral proteins that counteract the host anti-viral innate immune response. The Sendai virus protein C binds STAT1 directly to induce its degradation, whereas the V protein of simian virus 5 targets STAT1 for degradation by acting as an adaptor, without binding to STAT1.
subset: virus_checked
synonym: "promotion by virus of proteosome-dependent STAT2 degradation" EXACT []
synonym: "suppression by virus of host STAT2 activity by positive promotion of STAT2 proteasome-mediated degradation" EXACT [GOC:bf]
synonym: "targeting STAT2 for proteasome-mediated degradation" EXACT [VZ:257]
is_a: GO:0032436 ! positive regulation of proteasomal ubiquitin-dependent protein catabolic process
is_a: GO:0039564 ! suppression by virus of host STAT2 activity
created_by: rfoulger
creation_date: 2012-03-12T04:43:44Z

[Term]
id: GO:0039570
name: suppression by virus of host STAT2 activity by negative regulation of STAT protein import into nucleus
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT2 (signal transducer and activator of transcription-2) activity by retaining STAT2 in the cytoplasm, so STAT2 is unable to translocate to the nucleus to activate transcription of its target genes." [PMID:14557668]
comment: This term is for annotation of viral proteins that counteract the host anti-viral innate immune response.
subset: virus_checked
synonym: "cytoplasmic sequestering of STAT2" EXACT [GOC:bf]
synonym: "cytoplasmic sequestration of STAT2" EXACT [PMID:14557668]
is_a: GO:0039564 ! suppression by virus of host STAT2 activity
is_a: GO:0044833 ! modulation by virus of host protein transport
is_a: GO:1903652 ! modulation by virus of host cytoplasmic transport
is_a: GO:1990215 ! negative regulation by symbiont of host intracellular transport
is_a: GO:2000365 ! negative regulation of STAT protein import into nucleus
created_by: rfoulger
creation_date: 2012-03-12T04:46:49Z

[Term]
id: GO:0039571
name: suppression by virus of host STAT1 activity by negative regulation of STAT1 tyrosine phosphorylation
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT1 (signal transducer and activator of transcription-1) activity by stopping, preventing, or reducing the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT1 protein. For example, the measles virus V protein inhibits tyrosine phosphorylation of STAT1, thereby preventing STAT1 activation." [PMID:12804771]
comment: This term is for annotation of viral proteins that counteract the host anti-viral innate immune response.
subset: virus_checked
synonym: "inhibition by virus of tyrosine phosphorylation of STAT1" RELATED [PMID:12804771]
is_a: GO:0039563 ! suppression by virus of host STAT1 activity
is_a: GO:0039613 ! suppression by virus of host protein phosphorylation
is_a: GO:0042512 ! negative regulation of tyrosine phosphorylation of Stat1 protein
created_by: rfoulger
creation_date: 2012-03-12T04:50:38Z

[Term]
id: GO:0039572
name: suppression by virus of host STAT2 activity by negative regulation of STAT2 tyrosine phosphorylation
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT2 (signal transducer and activator of transcription-2) activity by stopping, preventing, or reducing the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT2 protein. For example, the measles virus V protein inhibits tyrosine phosphorylation of STAT2, thereby preventing STAT2 activation." [PMID:12804771]
subset: virus_checked
synonym: "inhibition by virus of tyrosine phosphorylation of STAT2" EXACT [PMID:12804771]
is_a: GO:0039564 ! suppression by virus of host STAT2 activity
is_a: GO:0039613 ! suppression by virus of host protein phosphorylation
is_a: GO:0042514 ! negative regulation of tyrosine phosphorylation of Stat2 protein
created_by: rfoulger
creation_date: 2012-03-12T04:53:50Z

[Term]
id: GO:0039573
name: suppression by virus of host complement activation
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of complement activation. The activation of complement involves the sequential proteolysis of proteins to generate enzymes with catalytic activities. The biological functions of the complement include opsonization, inflammation, lysis of immune complexes, or enhancement of the humoral immune response. For example, the virus complement control protein (VCP) of vaccinia virus, and the complement control protein of herpesvirus inhibit C3 convertase." [PMID:21191012, PMID:7745740, UniProtKB-KW:KW-1087, VZ:811]
subset: virus_checked
synonym: "inhibition of host complement activation by virus" EXACT [GOC:bf]
synonym: "inhibition of host complement cascade by virus" EXACT [GOC:bf]
synonym: "inhibition of host complement factors by virus" BROAD [UniProtKB-KW:KW-1087]
xref: VZ:811 "Inhibition of host complement factors by virus"
is_a: GO:0030683 ! evasion or tolerance by virus of host immune response
is_a: GO:0045916 ! negative regulation of complement activation
is_a: GO:0075528 ! modulation by virus of host immune response
intersection_of: GO:0019054 ! modulation by virus of host process
intersection_of: negatively_regulates GO:0006956 ! complement activation
relationship: negatively_regulates GO:0006956 ! complement activation
created_by: rfoulger

[Term]
id: GO:0039574
name: suppression by virus of host TYK2 activity
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host TYK2 (tyrosine kinase 2) activity. TYK2 is an intracellular signal-transducing tyrosine kinase that associates with the cytoplasmic tails of cytokine receptors and transmits the cytokine signal by phosphorylating receptor subunits." [UniProtKB-KW:KW-1112, VZ:720]
subset: virus_checked
synonym: "suppression by virus of host non-receptor tyrosine-protein kinase TYK2 activity" EXACT [PR:000016874]
xref: VZ:720 "Inhibition of host TYK2 by virus"
is_a: GO:0039503 ! suppression by virus of host innate immune response
is_a: GO:0039512 ! suppression by virus of host protein tyrosine kinase activity
created_by: rfoulger

[Term]
id: GO:0039575
name: suppression by virus of host TYK2 activity by negative regulation of TYK2 tyrosine phosphorylation
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host TYK2 (tyrosine kinase 2) activity by stopping, preventing or reducing phosphorylation and thereby activation of TYK2." [PMID:10523853, PMID:16987978, PMID:19254804]
subset: virus_checked
synonym: "inhibition by virus of host TYK2 activation" BROAD [GOC:bf, PMID:19254804]
synonym: "inhibition by virus of host TYK2 phosphorylation" EXACT [GOC:bf]
is_a: GO:0039574 ! suppression by virus of host TYK2 activity
created_by: rfoulger

[Term]
id: GO:0039576
name: suppression by virus of host JAK1 activity
namespace: biological_process
alt_id: GO:0039515
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host JAK1 (Janus Kinase 1) activity. In the host, binding of a ligand to a receptor triggers activation of JAK proteins, which phosphorylate tyrosine residues on the receptor creating sites for STAT proteins to bind, which are in turn phosphorylated and activated by JAK proteins. By blocking JAK1 activity, many viruses block the host signal transduction pathway." [UniProtKB-KW:KW-1096, VZ:784]
subset: virus_checked
synonym: "inhibition of host JAK activity by virus" NARROW [GOC:bf]
synonym: "negative regulation by virus of host JAK" EXACT [GOC:bf]
synonym: "negative regulation by virus of tyrosine phosphorylation of host STAT protein" NARROW [GOC:bf]
synonym: "suppression by virus of host janus kinase 1 activity" EXACT [PR:000009196]
synonym: "suppression by virus of tyrosine phosphorylation of host STAT protein" NARROW []
synonym: "viral inhibition of tyrosine phosphorylation of host STAT protein" NARROW [GOC:bf]
xref: VZ:784 "Inhibition of host JAK1 by virus"
is_a: GO:0039512 ! suppression by virus of host protein tyrosine kinase activity
is_a: GO:0039514 ! suppression by virus of host JAK-STAT cascade
created_by: rfoulger

[Term]
id: GO:0039577
name: suppression by virus of host JAK1 activity by negative regulation of JAK1 phosphorylation
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host JAK1 (Janus Kinase 1) activity by stopping, preventing or reducing tyrosine phosphorylation of JAK1 and thereby activation of JAK1." [PMID:12620806]
subset: virus_checked
is_a: GO:0039576 ! suppression by virus of host JAK1 activity
created_by: rfoulger

[Term]
id: GO:0039578
name: suppression by virus of host JAK1 activity via JAK1 binding
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host JAK1 (Janus Kinase 1) activity by interacting directly and selectively with JAK1. For example, the polyoma virus T antigen binds to JAK1 and renders it inactive." [PMID:9448289]
subset: virus_checked
is_a: GO:0039576 ! suppression by virus of host JAK1 activity
relationship: has_part GO:0019901 ! protein kinase binding
created_by: rfoulger

[Term]
id: GO:0039579
name: suppression by virus of host ISG15 activity
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host ubiquitin-like protein ISG15 activity. ISG15 is a ubiquitin-like protein that is conjugated to lysine residues on various target proteins. Viruses escape from the antiviral activity of ISG15 by using different mechanisms; the influenza B virus NS1 protein for instance blocks the covalent linkage of ISG15 to its target proteins by directly interacting with ISG15. The papain-like protease from the coronavirus cleaves ISG15 derivatives." [PMID:11157743, PMID:18604270, UniProtKB-KW:KW-1095, VZ:723]
subset: virus_checked
xref: VZ:723 "Inhibition of host ISG15 by virus"
is_a: GO:0039503 ! suppression by virus of host innate immune response
is_a: GO:0039507 ! suppression by virus of host molecular function
created_by: rfoulger

[Term]
id: GO:0039580
name: suppression by virus of host PKR activity
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host PKR (protein kinase regulated by RNA) activity. Activation of PKR involves dsRNA binding followed by autophosphorylation. Phosphorylated PKR can then phosphorylate downstream targets such as the translation initiation factor eIF2 to inhibit protein synthesis. Viruses encode a number of mechanisms to inhibit the host antiviral response via PKR, including direct interaction with PKR, promoting degradation of PKR or altering the subcellular location of PKR." [PMID:15207627, UniProtKB-KW:KW-1102, VZ:554]
subset: virus_checked
synonym: "suppression by virus of host EIF2AK2 activity" EXACT [PR:000006959, UniProtKB-KW:KW-1102]
xref: VZ:554 "Inhibition of host PKR by virus"
is_a: GO:0039503 ! suppression by virus of host innate immune response
is_a: GO:0039584 ! suppression by virus of host protein kinase activity
created_by: rfoulger

[Term]
id: GO:0039581
name: suppression by virus of host PKR activity via double-stranded RNA binding
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host PKR (protein kinase regulated by RNA) activity by interacting selectively and non-covalently with double-stranded RNA (dsRNA). Binding of viral proteins to RNA may sequester or alter the RNA so it can not be recognized by host PKR, or may compete with PKR for dsRNA binding." [PMID:7514679]
subset: virus_checked
synonym: "suppression by virus of host PKR activity by binding to dsRNA" EXACT [GOC:bf]
is_a: GO:0039580 ! suppression by virus of host PKR activity
relationship: has_part GO:0003725 ! double-stranded RNA binding
created_by: rfoulger

[Term]
id: GO:0039582
name: suppression by virus of host PKR activity by positive regulation of PKR nuclear localization
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host PKR (protein kinase regulated by RNA) activity by promoting the localization of PKR in the nucleus. For example, human cytomegalovirus (HMCV) gene products directly interact with PKR and inhibit its activation by sequestering it in the nucleus, away from both its activator (cytoplasmic dsRNA) and its substrate, (eIF2alpha)." [PMID:16987971]
subset: virus_checked
synonym: "suppression by virus of host PKR activity by nuclear sequestration of PKR" EXACT [GOC:bf]
synonym: "suppression by virus of host PKR activity by positive regulation of PKR localization to nucleus" EXACT [GOC:bf]
synonym: "suppression by virus of host PKR activity by sequestering of PKR in nucleus" EXACT [PMID:16987971]
is_a: GO:0039580 ! suppression by virus of host PKR activity
is_a: GO:1900182 ! positive regulation of protein localization to nucleus
created_by: rfoulger

[Term]
id: GO:0039583
name: suppression by virus of host PKR activity by positive regulation of PKR catabolic process
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host PKR (protein kinase regulated by RNA) activity by promoting the degradation of PKR via the proteosome. For example, the Rift Valley fever virus (RVFV) NSs protein induces the down-regulation of PKR by degradation through proteasomes." [PMID:19751406]
subset: virus_checked
synonym: "downregulation of PKR by degradation through proteosome" EXACT [PMID:19751406]
synonym: "promotion by virus of proteosome-dependent PKR degradation" EXACT [GOC:bf]
is_a: GO:0032436 ! positive regulation of proteasomal ubiquitin-dependent protein catabolic process
is_a: GO:0039580 ! suppression by virus of host PKR activity
created_by: rfoulger
creation_date: 2012-05-02T02:49:30Z

[Term]
id: GO:0039584
name: suppression by virus of host protein kinase activity
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host protein kinase activity." [GOC:bf]
subset: virus_checked
is_a: GO:0006469 ! negative regulation of protein kinase activity
is_a: GO:0039513 ! suppression by virus of host catalytic activity
is_a: GO:0039613 ! suppression by virus of host protein phosphorylation
created_by: rfoulger
creation_date: 2012-05-02T03:04:55Z

[Term]
id: GO:0039585
name: PKR signal transduction
namespace: biological_process
def: "A series of reactions in which a signal is passed on to downstream proteins within the cell via PKR, an intracellular protein kinase that is activated by stress signals or upon binding to double-stranded RNA (dsRNA), followed by autophosphorylation. PKR plays a role in the antiviral response, phosphorylating proteins such as the translation initiation factor eIF2 to inhibit protein synthesis during viral infection. Begins with activation of PKR activity, and ends with regulation of a downstream cellular process, e.g. regulation of transcription or inhibition of translation." [PMID:21204021, PMID:22102852, PMID:9843495, VZ:1576]
subset: virus_checked
synonym: "PKR signaling pathway" EXACT [PMID:22102852]
synonym: "signaling through PKR" EXACT [GOC:bf]
is_a: GO:0035556 ! intracellular signal transduction
created_by: rfoulger
creation_date: 2012-05-02T04:15:10Z

[Term]
id: GO:0039586
name: modulation by virus of host PP1 activity
namespace: biological_process
def: "The process in which a virus effects a change in host protein phosphatase-1 (PP1) activity, a serine/threonine phosphatase. Different viruses modulate host PP1 activity to remove phosphates from various cellular substrates and downregulate the host's antiviral response." [UniProtKB-KW:KW-1126, VZ:803]
subset: virus_checked
synonym: "modulation of host PP1 activity by virus" EXACT [UniProtKB-KW:KW-1126]
synonym: "regulation by virus of host PP1 activity" EXACT [GOC:bf]
xref: VZ:803 "Modulation of host PP1 activity by virus"
is_a: GO:0039517 ! modulation by virus of host protein serine/threonine phosphatase activity
created_by: rfoulger
creation_date: 2012-05-04T02:11:05Z

[Term]
id: GO:0039587
name: suppression by virus of host tetherin activity
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the activity of host tetherin activity. Tetherin (also known as BST2) is an alpha interferon-inducible cellular factor that impairs the release of many enveloped viruses. By blocking tetherin activity, many viruses circumvent its antiviral effects." [PMID:22493439, UniProtKB-KW:KW-1084, VZ:665]
subset: virus_checked
synonym: "inhibition of host BST2/Tetherin by virus" EXACT [UniProtKB-KW:KW-1084]
synonym: "suppression by virus of host BST-2 activity" EXACT [PMID:22493439]
xref: VZ:665 "Inhibition of host tetherin by virus"
is_a: GO:0039506 ! modulation by virus of host molecular function
created_by: rfoulger
creation_date: 2012-05-04T02:33:29Z

[Term]
id: GO:0039588
name: suppression by virus of host antigen processing and presentation
namespace: biological_process
def: "Any viral process that inhibits a host antigen-presenting cell expressing a peptide antigen on its cell surface in association with an MHC protein complex." [UniProtKB-KW:KW-1117, VZ:815]
subset: virus_checked
synonym: "inhibition of host proteasome antigen processing by virus" EXACT [UniProtKB-KW:KW-1117]
xref: VZ:815 "Inhibition of host proteasome antigen processing by virus"
is_a: GO:0002578 ! negative regulation of antigen processing and presentation
is_a: GO:0030683 ! evasion or tolerance by virus of host immune response
is_a: GO:0075528 ! modulation by virus of host immune response
intersection_of: GO:0019054 ! modulation by virus of host process
intersection_of: negatively_regulates GO:0019882 ! antigen processing and presentation
relationship: negatively_regulates GO:0019882 ! antigen processing and presentation
created_by: rfoulger
creation_date: 2012-05-04T04:34:52Z

[Term]
id: GO:0039589
name: suppression by virus of host TAP complex
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the activity of the host TAP complex, a heterodimer composed of the subunits TAP1 and TAP2 (transporter associated with antigen presentation). The TAP complex functions in the transport of antigenic peptides from the cytosol to the lumen of the endoplasmic reticulum, where they are loaded onto the MHC class I. By inhibiting the TAP complex, the virus prevents viral particles being presented at the cell surface, and thus evades the host immune response." [PMID:16691491, UniProtKB-KW:KW-1107, VZ:817]
comment: Viruses utilize multiple mechanisms to inhibit the TAP complex, including promoting degradation of the TAP proteins, interacting with the peptide-binding site of TAP to compete with peptide binding, and interacting with TAP to inhibit ATP binding and peptide-stimulated ATP hydrolysis.
synonym: "inhibition of host TAP by virus" EXACT [UniProtKB-KW:KW-1107]
xref: VZ:817 "Inhibition of host TAP by virus"
is_a: GO:0039504 ! suppression by virus of host adaptive immune response
is_a: GO:0039588 ! suppression by virus of host antigen processing and presentation
is_a: GO:1901040 ! negative regulation of peptide antigen transport
created_by: rfoulger
creation_date: 2012-06-22T14:42:06Z

[Term]
id: GO:0039591
name: suppression by virus of host tapasin activity
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host tapasin (TAP binding protein/TAPBP) activity. Tapasin is a type I transmembrane protein essential for the optimal expression of stable MHC class I molecules on the host cell surface. By inhibiting host tapasin activity, viruses can prevent presentation of their antigens at the cell surface, and thereby evade the host anti-viral immune response." [UniProtKB-KW:KW-1108, VZ:818]
comment: Consider also annotating to 'tapasin binding ; GO:0046980'.
subset: virus_checked
synonym: "inhibition of host tapasin by virus" EXACT [UniProtKB-KW:KW-1108]
synonym: "inhibition of host TAPBP by virus" EXACT [UniProtKB-KW:KW-1108]
synonym: "suppression by virus of host TAP binding protein" EXACT [HGNC:11566]
xref: VZ:818 "Inhibition of host tapasin by virus"
is_a: GO:0039507 ! suppression by virus of host molecular function
is_a: GO:0046776 ! suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I
created_by: rfoulger
creation_date: 2012-06-25T01:27:48Z

[Term]
id: GO:0039592
name: suppression by virus of G2/M transition of host mitotic cell cycle
namespace: biological_process
def: "Any viral process that decreases the rate or extent of progression from G2 phase to M phase of the host mitotic cell cycle." [UniProtKB-KW:KW-1079, VZ:876]
subset: virus_checked
synonym: "host G2/M cell cycle arrest by virus" EXACT [UniProtKB-KW:KW-1079]
xref: VZ:876 "Host G2/M cell cycle arrest by virus"
is_a: GO:0060153 ! modulation by virus of host cell cycle
created_by: rfoulger
creation_date: 2012-06-25T02:07:18Z

[Term]
id: GO:0039593
name: suppression by virus of host exit from mitosis
namespace: biological_process
def: "Any viral process which decreases the rate or extent of a host cell leaving M phase of the cell cycle. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [UniProtKB-KW:KW-1098, VZ:877]
subset: virus_checked
synonym: "inhibition of host mitotic exit by virus" EXACT [UniProtKB-KW:KW-1098, VZ:877]
xref: VZ:877 "Inhibition of host mitotic exit by virus"
is_a: GO:0060153 ! modulation by virus of host cell cycle
created_by: rfoulger
creation_date: 2012-06-25T02:21:20Z

[Term]
id: GO:0039594
name: endoribonuclease activity involved in viral induction of host mRNA catabolic process
namespace: molecular_function
def: "Any endoribonuclease activity that contributes to the viral-induced catabolism of host mRNA." [GOC:bf, PMID:22046136]
comment: GO:0039594 can be used to annotate a host or viral endoribonuclease activity that cleaves host mRNA in response to a viral infection.
subset: virus_checked
is_a: GO:0004521 ! endoribonuclease activity
relationship: part_of GO:0039599 ! cleavage by virus of host mRNA
relationship: part_of GO:0039600 ! induction by virus of host endonucleolytic cleavage-dependent mRNA catabolic process
created_by: rfoulger
creation_date: 2012-07-05T11:21:26Z

[Term]
id: GO:0039595
name: induction by virus of catabolism of host mRNA
namespace: biological_process
def: "The process in which a virus increases the frequency, rate or extent of the breakdown of host messenger RNA (mRNA)." [GOC:bf, UniProtKB-KW:KW-1132]
subset: virus_checked
synonym: "induction by virus of host mRNA catabolic process" EXACT [GOC:bf]
synonym: "induction of host mRNA decay" EXACT [VZ:901]
synonym: "promotion of host mRNA degradation" EXACT []
synonym: "viral induction of host mRNA decay" EXACT [GOC:bf]
synonym: "virus-mediated mRNA decay" EXACT [VZ:901]
xref: VZ:901 "Virus-mediated host mRNA decay"
is_a: GO:0019054 ! modulation by virus of host process
is_a: GO:0061014 ! positive regulation of mRNA catabolic process
created_by: rfoulger
creation_date: 2012-07-04T03:14:04Z

[Term]
id: GO:0039596
name: modulation by virus of host protein dephosphorylation
namespace: biological_process
def: "Any viral process that modulates the frequency, rate or extent of dephosphorylation of a host protein." [GOC:bf]
subset: virus_checked
is_a: GO:0019054 ! modulation by virus of host process
is_a: GO:0035304 ! regulation of protein dephosphorylation
created_by: rfoulger
creation_date: 2012-07-19T11:46:23Z

[Term]
id: GO:0039597
name: induction by virus of host endoribonuclease activity
namespace: biological_process
def: "Any viral process that activates or increases the frequency, rate or extent of host endoribonuclease activity." [PMID:22174690]
comment: GO:0039597 should be used to annotate viral proteins which utilize a host RNase to induce endonucleolytic cleavage of mRNAs (e.g. the NSP1 protein of SARS coronavirus). For viral proteins that have endoribonuclease activity themselves, consider instead annotating to: 'endoribonuclease activity involved in viral induction of host mRNA catabolic process ; GO:0039594'.
subset: virus_checked
synonym: "viral induction of host RNAse activity" EXACT [GOC:bf]
is_a: GO:0039600 ! induction by virus of host endonucleolytic cleavage-dependent mRNA catabolic process
is_a: GO:0039712 ! induction by virus of host catalytic activity
is_a: GO:1902380 ! positive regulation of endoribonuclease activity
created_by: rfoulger
creation_date: 2012-07-04T04:36:49Z

[Term]
id: GO:0039598
name: obsolete induction by virus of host nuclear polyadenylation-dependent mRNA catabolic process
namespace: biological_process
def: "OBSOLETE. The process in which a virus increases the frequency, rate or extent of the breakdown of host messenger RNA (mRNA) initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target mRNA." [GOC:sp]
comment: This term was made obsolete because it is unclear what role the viral protein is playing in this process. and there is insufficient evidence to use this term for annotation.
subset: virus_checked
synonym: "induction by virus of host nuclear poly(A)-dependent mRNA catabolic process" RELATED [GOC:vw]
synonym: "induction by virus of host nuclear polyadenylation-dependent mRNA catabolic process" EXACT []
synonym: "virus-mediated host mRNA decay by hyperadenylation" NARROW [GOC:sp]
is_obsolete: true
created_by: rfoulger
creation_date: 2012-07-04T04:44:16Z

[Term]
id: GO:0039599
name: cleavage by virus of host mRNA
namespace: biological_process
def: "Any process in which a host pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner by a viral endoribonuclease." [PMID:22046136]
subset: virus_checked
synonym: "host mRNA cleavage by viral endoribonuclease" EXACT [GOC:bf]
synonym: "viral endoribonuclease activity involved in degradation of host mRNA" RELATED [GOC:bf]
is_a: GO:0006379 ! mRNA cleavage
is_a: GO:0019048 ! modulation by virus of host morphology or physiology
is_a: GO:0044033 ! multi-organism metabolic process
created_by: rfoulger
creation_date: 2012-07-04T05:09:08Z

[Term]
id: GO:0039600
name: induction by virus of host endonucleolytic cleavage-dependent mRNA catabolic process
namespace: biological_process
def: "The process in which a virus increases the frequency, rate or extent of the breakdown of host nuclear-transcribed mRNAs that begins with endonucleolytic cleavage (by either a host or a viral RNAse) to generate unprotected ends." [GOC:bf, PMID:22174690]
comment: Some viruses utilize a host RNase to induce endonucleolytic cleavage of template mRNAs (e.g. the NSP1 protein of SARS coronavirus); for these consider instead annotating to the child term 'induction by virus of host endoribonuclease activity ; GO:0039597'. Other viral proteins act as endonucleases themselves to cleave mRNA and then rely on the host degradation machinery to clear the resulting fragments (e.g. gamma herpesvirus SOX protein); for these cases consider instead annotating to the child term 'endoribonuclease activity involved in viral induction of host mRNA catabolic process ; GO:0039594'.
subset: virus_checked
synonym: "induction by virus of host endonucleolytic cleavage-dependent mRNA decay" EXACT [GOC:bf]
synonym: "induction by virus of host nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay" EXACT [GOC:bf]
is_a: GO:0039595 ! induction by virus of catabolism of host mRNA
created_by: rfoulger
creation_date: 2012-07-04T05:23:43Z

[Term]
id: GO:0039602
name: suppression by virus of host transcription initiation from RNA polymerase II promoter
namespace: biological_process
alt_id: GO:0039601
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a host DNA template." [UniProtKB-KW:KW-1111, VZ:904]
subset: virus_checked
synonym: "inhibition of host transcription initiation by virus" EXACT [GOC:bf]
synonym: "suppression by virus of host DNA-dependent transcription, initiation" EXACT []
xref: VZ:904 "Inhibition of host transcription initiation by virus"
is_a: GO:0039653 ! suppression by virus of host transcription
created_by: rfoulger
creation_date: 2012-07-05T03:29:34Z

[Term]
id: GO:0039603
name: TBP-class protein binding involved in viral suppression of host transcription initiation from RNA polymerase II promoter
namespace: molecular_function
def: "Selective and non-covalent interaction of a viral protein with a member of the class of TATA-binding proteins (TBP) in the host, including any of the TBP-related factors (TRFs), which contributes to the viral-suppression of assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a host DNA template." [GOC:vw, PMID:11968006]
subset: virus_checked
is_a: GO:0017025 ! TBP-class protein binding
relationship: part_of GO:0039602 ! suppression by virus of host transcription initiation from RNA polymerase II promoter
created_by: rfoulger
creation_date: 2012-07-05T04:00:15Z

[Term]
id: GO:0039604
name: suppression by virus of host translation
namespace: biological_process
def: "Any process in which a virus prevents or reduces the frequency, rate or extent of translation of host mRNA." [UniProtKB-KW:KW-1193, VZ:1579]
subset: virus_checked
synonym: "host translation shutoff by virus" EXACT [UniProtKB-KW:KW-1193, VZ:1579]
synonym: "viral inhibition of cellular protein synthesis" EXACT [VZ:1579]
synonym: "viral shutoff of host protein synthesis" EXACT [PMID:8643618]
xref: VZ:1579 "Translation shutoff"
is_a: GO:0019057 ! modulation by virus of host translation
is_a: GO:0039657 ! suppression by virus of host gene expression
created_by: rfoulger
creation_date: 2012-07-05T04:25:22Z

[Term]
id: GO:0039605
name: TFIIB-class transcription factor binding involved in viral suppression of host transcription initiation from RNA polymerase II promoter
namespace: molecular_function
def: "Selective and non-covalent interaction of a viral protein with a member of the TFIIB-class of host transcription factors, which contributes to the viral-suppression of assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a host DNA template." [GOC:vw, PMID:18768974]
subset: virus_checked
is_a: GO:0001093 ! TFIIB-class transcription factor binding
relationship: part_of GO:0039602 ! suppression by virus of host transcription initiation from RNA polymerase II promoter
created_by: rfoulger
creation_date: 2012-07-05T04:16:45Z

[Term]
id: GO:0039606
name: suppression by virus of host translation initiation
namespace: biological_process
def: "Any process in which a virus prevents or reduces the frequency, rate or extent of host translation initiation, the host process preceding formation of the peptide bond between the first two amino acids of a protein." [GOC:bf]
subset: virus_checked
is_a: GO:0039604 ! suppression by virus of host translation
created_by: rfoulger
creation_date: 2012-07-05T04:44:10Z

[Term]
id: GO:0039607
name: proteolysis by virus of host translation initiation factor
namespace: biological_process
def: "The chemical reactions and pathways performed by a virus resulting in the hydrolysis of a host translation initiation factor by cleavage of its peptide bonds." [PMID:18572216]
subset: virus_checked
synonym: "cleavage of host translation initiation factor by viral protease" EXACT [GOC:bf]
synonym: "cleavage of host translation initiation factor by virus" RELATED [GOC:sp]
synonym: "proteolytic cleavage by virus of host translation initiation factor" EXACT [GOC:bf]
synonym: "suppression by virus of host translation initiation factor activity by proteolysis" EXACT [GOC:bf]
is_a: GO:0035897 ! proteolysis in other organism
is_a: GO:0039611 ! suppression by virus of host translation initiation factor activity
created_by: rfoulger
creation_date: 2012-07-05T04:46:21Z

[Term]
id: GO:0039608
name: suppression by virus of host translation initiation factor activity by induction of host protein dephosphorylation
namespace: biological_process
def: "Any process in which a virus prevents or reduces the frequency, rate or extent of activity of a host translation initiation factor by promoting dephosphorylation of a host protein." [PMID:12239292, PMID:8643618]
comment: GO:0039608 can be used to annotate viral proteins which promote dephosphorylation of a host translation initiation factor itself (e.g. eIF4E) or promote dephosphorylation of a host protein that, when un-phosphorylated, inactivates a translation initiation factor. For example, the transcriptional repressor and eIF4E-binding protein 4E-BP1 is activated by dephosphorylation upon EMCV and poliovirus infections.
subset: virus_checked
is_a: GO:0035307 ! positive regulation of protein dephosphorylation
is_a: GO:0039596 ! modulation by virus of host protein dephosphorylation
is_a: GO:0039611 ! suppression by virus of host translation initiation factor activity
created_by: rfoulger
creation_date: 2012-07-06T10:30:57Z

[Term]
id: GO:0039611
name: suppression by virus of host translation initiation factor activity
namespace: biological_process
def: "Any process in which a virus prevents or reduces the frequency, rate or extent of activity of a host translation initiation factor." [GOC:bf, UniProtKB-KW:KW-1075]
subset: virus_checked
synonym: "inactivation of eIF2 activity" NARROW [PMID:12239292]
synonym: "inhibition of activity of host translation initiation factor" EXACT [PMID:12239292]
synonym: "Inhibition of host translation factors by virus" BROAD [UniProtKB-KW:KW-1075]
synonym: "suppression by virus of host EIF-4E activity" EXACT [GOC:bf]
is_a: GO:0039507 ! suppression by virus of host molecular function
is_a: GO:0039606 ! suppression by virus of host translation initiation
created_by: rfoulger
creation_date: 2012-07-06T10:27:16Z

[Term]
id: GO:0039612
name: modulation by virus of host protein phosphorylation
namespace: biological_process
def: "Any viral process that modulates the frequency, rate or extent of phosphorylation of viral or host proteins in a host." [GOC:bf]
subset: virus_checked
is_a: GO:0001932 ! regulation of protein phosphorylation
is_a: GO:0019054 ! modulation by virus of host process
created_by: rfoulger
creation_date: 2012-07-06T11:13:59Z

[Term]
id: GO:0039613
name: suppression by virus of host protein phosphorylation
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of phosphorylation of viral or host proteins in a host." [GOC:bf]
subset: virus_checked
synonym: "viral inhibition of host protein phosphorylation" EXACT [GOC:bf]
is_a: GO:0001933 ! negative regulation of protein phosphorylation
is_a: GO:0039612 ! modulation by virus of host protein phosphorylation
created_by: rfoulger
creation_date: 2012-07-06T11:15:56Z

[Term]
id: GO:0039614
name: induction by virus of host protein phosphorylation
namespace: biological_process
def: "Any process in which a virus activates or increases the frequency, rate or extent of phosphorylation of viral or host proteins in a host." [GOC:bf]
subset: virus_checked
is_a: GO:0001934 ! positive regulation of protein phosphorylation
is_a: GO:0039612 ! modulation by virus of host protein phosphorylation
created_by: rfoulger
creation_date: 2012-07-06T11:15:56Z

[Term]
id: GO:0039615
name: T=1 icosahedral viral capsid
namespace: cellular_component
def: "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=1 symmetry. The T=1 capsid is composed of 12 pentameric capsomeres." [UniProtKB-KW:KW-1140, VZ:1057]
subset: virus_checked
xref: VZ:1057 "T=1 icosahedral capsid protein"
is_a: GO:0019030 ! icosahedral viral capsid
created_by: rfoulger
creation_date: 2012-07-18T01:46:17Z

[Term]
id: GO:0039616
name: T=2 icosahedral viral capsid
namespace: cellular_component
def: "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=2 symmetry. The T=2 capsid is composed of 12 pentameric dimers." [UniProtKB-KW:KW-1141, VZ:838]
comment: The T=2 symmetry is an non-official appellation; strictly speaking the capsid has a T=1 symmetry with each unit composed of a homodimer.
subset: virus_checked
xref: VZ:838 "T=2 icosahedral capsid protein"
is_a: GO:0019030 ! icosahedral viral capsid
created_by: rfoulger
creation_date: 2012-07-18T02:01:55Z

[Term]
id: GO:0039617
name: T=3 icosahedral viral capsid
namespace: cellular_component
def: "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=3 symmetry. The T=3 capsid is composed of 12 pentameric and 20 hexameric capsomeres." [UniProtKB-KW:KW-1142, VZ:806]
subset: virus_checked
xref: VZ:806 "T=3 icosahedral capsid protein"
is_a: GO:0019030 ! icosahedral viral capsid
created_by: rfoulger
creation_date: 2012-07-18T02:07:40Z

[Term]
id: GO:0039618
name: T=pseudo3 icosahedral viral capsid
namespace: cellular_component
def: "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with pseudo T=3 symmetry. The T=pseudo3 capsid is composed of 12 pentameric and 20 hexameric capsomeres." [UniProtKB-KW:KW-1143, VZ:809]
comment: T=pseudo3 capsids are not T=3 symmetry as described by Caspar and Klug (PMID:14019094) because the basic unit is composed of three different proteins. Since the three subunits are morphologically very similar, the structure is therefore a pseudo T=3.
subset: virus_checked
xref: VZ:809 "T=pseudo3 icosahedral capsid protein"
is_a: GO:0019030 ! icosahedral viral capsid
created_by: rfoulger
creation_date: 2012-07-18T02:10:02Z

[Term]
id: GO:0039619
name: T=4 icosahedral viral capsid
namespace: cellular_component
def: "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=4 symmetry. The T=4 capsid is composed of 12 pentameric and 30 hexameric capsomeres." [UniProtKB-KW:KW-1144, VZ:808]
subset: virus_checked
xref: VZ:808 "T=4 icosahedral capsid protein"
is_a: GO:0019030 ! icosahedral viral capsid
created_by: rfoulger
creation_date: 2012-07-18T02:15:14Z

[Term]
id: GO:0039620
name: T=7 icosahedral viral capsid
namespace: cellular_component
def: "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=7 symmetry. The T=7 capsid is composed of 12 pentameric and 60 hexameric capsomeres." [UniProtKB-KW:KW-1145, VZ:804]
comment: Spherical viruses with T numbers greater than or equal to 7 are skewed. They are therefore described as either right-handed (dextro) or left-handed (laevo).
subset: virus_checked
xref: VZ:804 "T=7 icosahedral capsid protein"
is_a: GO:0019030 ! icosahedral viral capsid
created_by: rfoulger
creation_date: 2012-07-18T02:16:40Z

[Term]
id: GO:0039621
name: T=13 icosahedral viral capsid
namespace: cellular_component
def: "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=13 symmetry. The T=13 capsid is composed of 12 pentameric and 120 hexameric capsomeres." [UniProtKB-KW:KW-1146, VZ:260]
subset: virus_checked
xref: VZ:260 "T=13 icosahedral capsid protein"
is_a: GO:0019030 ! icosahedral viral capsid
created_by: rfoulger
creation_date: 2012-07-18T02:18:59Z

[Term]
id: GO:0039622
name: T=16 icosahedral viral capsid
namespace: cellular_component
def: "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=16 symmetry. The T=16 capsid is composed of 12 pentameric and 150 hexameric capsomeres." [UniProtKB-KW:KW-1147, VZ:807]
subset: virus_checked
xref: VZ:807 "T=16 icosahedral capsid protein"
is_a: GO:0019030 ! icosahedral viral capsid
created_by: rfoulger
creation_date: 2012-07-18T02:20:23Z

[Term]
id: GO:0039623
name: T=25 icosahedral viral capsid
namespace: cellular_component
def: "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=25 symmetry. The T=25 capsid is composed of 12 pentameric and 240 hexameric capsomeres." [UniProtKB-KW:KW-1148, VZ:810]
subset: virus_checked
xref: VZ:810 "T=25 icosahedral capsid protein"
is_a: GO:0019030 ! icosahedral viral capsid
created_by: rfoulger
creation_date: 2012-07-18T02:21:43Z

[Term]
id: GO:0039624
name: viral outer capsid
namespace: cellular_component
def: "The outer layer of a double or triple concentric icosahedral capsid. Outer capsids are part of reoviridae and cystoviridae virions." [UniProtKB-KW:KW-1152]
subset: virus_checked
synonym: "outer capsid" EXACT [GOC:bf]
is_a: GO:0044423 ! virion part
relationship: part_of GO:0019030 ! icosahedral viral capsid
created_by: rfoulger
creation_date: 2012-07-18T04:03:16Z

[Term]
id: GO:0039625
name: viral inner capsid
namespace: cellular_component
def: "The inner layer of a double or triple concentric icosahedral capsid. Inner capsids are part of reoviridae and cystoviridae virions." [UniProtKB-KW:KW-1153]
subset: virus_checked
synonym: "inner capsid" EXACT [GOC:bf]
is_a: GO:0044423 ! virion part
relationship: part_of GO:0019030 ! icosahedral viral capsid
created_by: rfoulger
creation_date: 2012-07-18T04:05:35Z

[Term]
id: GO:0039626
name: viral intermediate capsid
namespace: cellular_component
def: "The intermediate layer of a triple concentric icosahedral capsid. Intermediate capsids are part of reoviridae virions." [UniProtKB-KW:KW-1154]
subset: virus_checked
synonym: "intermediate capsid" EXACT [GOC:bf]
is_a: GO:0044423 ! virion part
relationship: part_of GO:0019030 ! icosahedral viral capsid
created_by: rfoulger
creation_date: 2012-07-18T04:06:25Z

[Term]
id: GO:0039627
name: T=147 icosahedral capsid
namespace: cellular_component
def: "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=147 symmetry. T=147 icosahedral capsid is composed of 12 pentameric and 1460 hexameric capsomeres for a total of 8820 capsid proteins." [GOC:plm, UniProtKB-KW:KW-0167]
subset: virus_checked
is_a: GO:0019030 ! icosahedral viral capsid
created_by: rfoulger
creation_date: 2012-08-03T16:18:49Z

[Term]
id: GO:0039628
name: T=169 icosahedral viral capsid
namespace: cellular_component
def: "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=169 symmetry. T=169 icosahedral capsid is composed of 12 pentameric and 1680 hexameric capsomeres for a total of 10140 capsid proteins." [GOC:plm, UniProtKB-KW:KW-1150]
subset: virus_checked
synonym: "T=169 icosahedral capsid" EXACT [GOC:bf]
is_a: GO:0019030 ! icosahedral viral capsid
created_by: rfoulger
creation_date: 2012-08-03T16:27:55Z

[Term]
id: GO:0039629
name: T=219 icosahedral capsid
namespace: cellular_component
def: "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=219 symmetry. T=219 icosahedral capsid is composed of 12 pentameric and 2180 hexameric capsomeres for a total of 13140 capsid proteins." [GOC:plm, UniProtKB-KW:KW-1151]
subset: virus_checked
is_a: GO:0019030 ! icosahedral viral capsid
created_by: rfoulger
creation_date: 2012-08-03T16:29:00Z

[Term]
id: GO:0039630
name: RNA translocase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive movement along a single- or double-stranded RNA molecule." [GOC:bm, PMID:22713318]
comment: Note that some gene products that possess DNA translocase activity, such as members of the FtsK/SpoIIIE family, can be fixed in place by interactions with other components of the cell; the relative movement between the protein and DNA bound to it results in movement of the DNA within the cell, often across a membrane.
is_a: GO:0008186 ! RNA-dependent ATPase activity
created_by: rfoulger
creation_date: 2012-08-06T13:24:51Z

[Term]
id: GO:0039631
name: DNA translocase activity involved in viral DNA genome packaging
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive movement along a single- or double-stranded DNA molecule, that contributes to the packing of viral DNA into a capsid." [GOC:bm, PMID:17501915]
synonym: "viral DNA packaging activity" RELATED [GOC:bm]
synonym: "viral DNA packaging motor activity" RELATED [PMID:17501915]
is_a: GO:0015616 ! DNA translocase activity
intersection_of: GO:0015616 ! DNA translocase activity
intersection_of: part_of GO:0019073 ! viral DNA genome packaging
relationship: part_of GO:0019073 ! viral DNA genome packaging
created_by: rfoulger
creation_date: 2012-08-07T11:17:07Z

[Term]
id: GO:0039632
name: RNA translocase activity involved in viral RNA genome packaging
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive movement along a single- or double-stranded RNA molecule, which contributes to the packaging of viral RNA into a nucleocapsid." [GOC:bm, PMID:22297533]
synonym: "RNA packaging ATPase activity" EXACT [PMID:22297533]
synonym: "viral RNA packaging activity" RELATED [GOC:bm]
is_a: GO:0039630 ! RNA translocase activity
intersection_of: GO:0039630 ! RNA translocase activity
intersection_of: part_of GO:0019074 ! viral RNA genome packaging
relationship: part_of GO:0019074 ! viral RNA genome packaging
created_by: rfoulger
creation_date: 2012-08-07T11:20:53Z

[Term]
id: GO:0039633
name: killing by virus of host cell
namespace: biological_process
def: "Any process mediated by a virus that results in the death of a cell in the host organism." [GOC:bf, GOC:bm, GOC:jl]
subset: goslim_virus
synonym: "killing by phage of host cells" NARROW [GOC:bm]
synonym: "killing by virus of host cells" EXACT []
is_a: GO:0001907 ! killing by symbiont of host cells
is_a: GO:0019048 ! modulation by virus of host morphology or physiology
created_by: rfoulger
creation_date: 2012-08-10T14:44:40Z

[Term]
id: GO:0039634
name: killing by virus of host cell during superinfection exclusion
namespace: biological_process
def: "The viral-killing of a host cell by a pre-existing virus in response to a subsequent infection of the host cell by second virus." [GOC:bf, GOC:bm, GOC:jl, PMID:22398285]
synonym: "killing by virus of host cells during superinfection exclusion" EXACT []
synonym: "killing by virus of host cells involved in superinfection exclusion" EXACT [GOC:bf]
synonym: "Rex exclusion" NARROW []
is_a: GO:0009615 ! response to virus
is_a: GO:0039633 ! killing by virus of host cell
created_by: rfoulger
creation_date: 2012-08-10T14:46:03Z

[Term]
id: GO:0039635
name: suppression by virus of host peptidoglycan biosynthetic process
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of peptidoglycan biosynthesis in the host organism. Peptidoglycans are any of a class of glycoconjugates found in bacterial cell walls." [GOC:bf, GOC:bm, GOC:jl]
synonym: "viral inhibition of host peptidoglycan biosynthesis" RELATED [GOC:bf]
is_a: GO:0039636 ! suppression by virus of host cell wall biogenesis
created_by: rfoulger
creation_date: 2012-08-10T14:58:12Z

[Term]
id: GO:0039636
name: suppression by virus of host cell wall biogenesis
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of cell wall biogenesis in the host organism. Cell wall biogenesis includes the biosynthesis of constituent macromolecules, and the assembly and arrangement of these constituent parts." [GOC:bf, GOC:bm, GOC:jl]
is_a: GO:0019054 ! modulation by virus of host process
created_by: rfoulger
creation_date: 2012-08-10T15:04:12Z

[Term]
id: GO:0039637
name: catabolism by virus of host DNA
namespace: biological_process
def: "The breakdown of host DNA, deoxyribonucleic acid, by a virus." [GOC:bf, GOC:bm, GOC:jl]
subset: virus_checked
is_a: GO:0006308 ! DNA catabolic process
is_a: GO:0019048 ! modulation by virus of host morphology or physiology
is_a: GO:0044035 ! multi-organism catabolic process
created_by: rfoulger
creation_date: 2012-08-10T15:59:22Z

[Term]
id: GO:0039638
name: lipopolysaccharide-mediated virion attachment to host cell
namespace: biological_process
def: "The process by which a virion attaches to a host cell by binding to a lipopolysaccharide (LPS) on the host cell surface." [GOC:bf, GOC:bm, PMID:12837775]
subset: virus_checked
synonym: "lipopolysaccharide binding involved in viral attachment to host cell" EXACT [GOC:bf, GOC:bm]
synonym: "LPS binding involved in viral attachment to host cell" EXACT [GOC:bf]
synonym: "virion attachment, binding to host lipopolysaccharide" EXACT [GOC:bf, GOC:jl]
is_a: GO:0019062 ! virion attachment to host cell
relationship: has_part GO:0001530 ! lipopolysaccharide binding
created_by: rfoulger
creation_date: 2012-08-17T10:13:06Z

[Term]
id: GO:0039639
name: suppression by virus of host cell lysis in response to superinfection
namespace: biological_process
def: "The prevention or delay of host cell lysis by a pre-existing virus in response to a subsequent infection of the host cell by second virus." [GOC:bm, GOC:jl, PMID:22389108, PMID:9560373]
synonym: "lysis inhibition" BROAD [GOC:bm, PMID:22389108]
synonym: "suppression by virus of host cell lysis in response to superinfecting virus" EXACT [GOC:bf]
is_a: GO:0001899 ! negative regulation of cytolysis by symbiont of host cells
is_a: GO:0098586 ! cellular response to virus
created_by: rfoulger
creation_date: 2012-08-17T10:42:27Z

[Term]
id: GO:0039640
name: cytolysis by virus via suppression of host peptidoglycan biosynthetic process
namespace: biological_process
def: "The killing by a virus of host cell by cytolysis, caused by a virus stopping, preventing, or reducing peptidoglycan biosynthesis in the host organism. Peptidoglycans are any of a class of glycoconjugates found in bacterial cell walls." [GOC:bf, GOC:bm]
is_a: GO:0044659 ! cytolysis by virus of host cell
relationship: has_part GO:0039635 ! suppression by virus of host peptidoglycan biosynthetic process
created_by: rfoulger
creation_date: 2012-08-17T10:54:55Z

[Term]
id: GO:0039641
name: viral inner membrane
namespace: cellular_component
def: "The lipid bilayer of a virion contained inside the protein capsid." [GOC:bm, PMID:15331712]
synonym: "virion inner membrane" EXACT [GOC:bf, GOC:bm, GOC:jl]
is_a: GO:0036338 ! viral membrane
created_by: rfoulger
creation_date: 2012-09-07T13:29:48Z

[Term]
id: GO:0039642
name: virion nucleoid
namespace: cellular_component
def: "The region of a virion in which the nucleic acid is confined." [GOC:bm, PMID:14291596]
is_a: GO:0009295 ! nucleoid
is_a: GO:0044423 ! virion part
intersection_of: GO:0009295 ! nucleoid
intersection_of: part_of GO:0019012 ! virion
relationship: part_of GO:0019012 ! virion
created_by: rfoulger
creation_date: 2012-09-07T14:14:52Z

[Term]
id: GO:0039643
name: host cell viral nucleoid
namespace: cellular_component
def: "The region of a host cell that contains the viral genome." [GOC:bf, GOC:bm, GOC:jl]
comment: To annotate the region of the complete virus particle in which the viral genome is contained, instead use 'virion nucleoid ; GO:0039642'.
is_a: GO:0033643 ! host cell part
created_by: rfoulger
creation_date: 2012-09-07T15:41:18Z

[Term]
id: GO:0039644
name: suppression by virus of host NF-kappaB transcription factor activity
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the activity of host NF-kappaB activity." [UniProtKB-KW:KW-1100, VZ:695]
synonym: "inhibition of host NF-kappa-B by virus" EXACT [UniProtKB-KW:KW-1100, VZ:695]
xref: VZ:695 "Inhibition of host NF-kappa-B by virus"
is_a: GO:0039507 ! suppression by virus of host molecular function
is_a: GO:0039653 ! suppression by virus of host transcription
created_by: rfoulger
creation_date: 2012-10-09T15:04:27Z

[Term]
id: GO:0039645
name: modulation by virus of host G1/S transition checkpoint
namespace: biological_process
def: "Any viral process that modulates the frequency, rate or extent of the host cell G1/S transition checkpoint." [UniProtKB-KW:KW-1078]
synonym: "G1/S host cell cycle checkpoint dysregulation by virus" EXACT [UniProtKB-KW:KW-1078, VZ:880]
xref: VZ:880 "G1/S host cell cycle checkpoint dysregulation by virus"
is_a: GO:0060153 ! modulation by virus of host cell cycle
created_by: rfoulger
creation_date: 2012-10-09T15:08:57Z

[Term]
id: GO:0039646
name: modulation by virus of host G0/G1 transition checkpoint
namespace: biological_process
def: "Any viral process that modulates the frequency, rate or extent of the host cell G0/G1 transition checkpoint." [UniProtKB-KW:KW-1077]
subset: virus_checked
synonym: "G0/G1 host cell cycle checkpoint dysregulation by virus" EXACT [UniProtKB-KW:KW-1077, VZ:881]
xref: VZ:881 "G0/G1 host cell cycle checkpoint dysregulation by virus"
is_a: GO:0060153 ! modulation by virus of host cell cycle
created_by: rfoulger
creation_date: 2012-10-09T15:11:22Z

[Term]
id: GO:0039647
name: suppression by virus of host poly(A)-binding protein activity
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host poly(A)-binding protein (PABP) activity. PABP binds to the poly(A) tail of mRNA to facilitate translation." [UniProtKB-KW:KW-1101]
synonym: "inhibition of host poly(A)-binding protein by virus" EXACT [UniProtKB-KW:KW-1101]
synonym: "suppression by virus of host PABP activity" EXACT [Wikipedia:Poly(A)-binding_protein]
is_a: GO:0039507 ! suppression by virus of host molecular function
is_a: GO:0039604 ! suppression by virus of host translation
created_by: rfoulger
creation_date: 2012-10-09T15:14:07Z

[Term]
id: GO:0039648
name: modulation by virus of host protein ubiquitination
namespace: biological_process
def: "Any process in which a virus modulates the frequency, rate or extent of protein ubiquitination in the host organism. Ubiquitination is the process in which one or more ubiquitin groups are added to a protein." [UniProtKB-KW:KW-1130]
synonym: "modulation of host ubiquitin pathway by virus" RELATED [UniProtKB-KW:KW-1130]
is_a: GO:0019054 ! modulation by virus of host process
created_by: rfoulger
creation_date: 2012-10-09T15:20:47Z

[Term]
id: GO:0039649
name: modulation by virus of host ubiquitin-protein ligase activity
namespace: biological_process
def: "The process in which a virus effects a change in host ubiquitin-protein ligase activity. Ubiquitin-protein ligase activity catalyzes the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine." [UniProtKB-KW:KW-1123]
subset: virus_checked
synonym: "modulation of host E3 ubiquitin ligases by virus" NARROW [UniProtKB-KW:KW-1123]
is_a: GO:0039516 ! modulation by virus of host catalytic activity
is_a: GO:0039648 ! modulation by virus of host protein ubiquitination
is_a: GO:0051438 ! regulation of ubiquitin-protein transferase activity
created_by: rfoulger
creation_date: 2012-10-09T15:26:56Z

[Term]
id: GO:0039650
name: suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host caspase activity. Caspases are cysteine-type endopeptidases which contribute to the apoptotic process." [UniProtKB-KW:KW-1085, VZ:912]
synonym: "inhibition of host caspases by virus" NARROW [UniProtKB-KW:KW-1085, VZ:912]
is_a: GO:0019050 ! suppression by virus of host apoptotic process
is_a: GO:0039513 ! suppression by virus of host catalytic activity
is_a: GO:0043154 ! negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
created_by: rfoulger
creation_date: 2012-10-09T15:30:48Z

[Term]
id: GO:0039651
name: induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process
namespace: biological_process
def: "Any process in which a virus increases the frequency, rate or extent of host cysteine-type endopeptidase activity (also called caspase activity) which contributes to the apoptotic process." [GOC:mtg_apoptosis, UniProtKB-KW:KW-1073]
synonym: "activation of host caspases by virus" NARROW [UniProtKB-KW:KW-1073]
synonym: "induction by virus of host caspase activity" NARROW [GOC:bf, GOC:jl]
is_a: GO:0019051 ! induction by virus of host apoptotic process
is_a: GO:0039712 ! induction by virus of host catalytic activity
is_a: GO:0043280 ! positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
created_by: rfoulger
creation_date: 2012-10-09T15:44:29Z

[Term]
id: GO:0039652
name: activation by virus of host NF-kappaB transcription factor activity
namespace: biological_process
def: "Any process in which a virus starts, promotes, or enhances the activity of the host transcription factor NF-kappaB." [UniProtKB-KW:KW-1074]
subset: virus_checked
synonym: "activation of host NF-kappa-B by virus" EXACT [UniProtKB-KW:KW-1074]
xref: VZ:841 "Activation of host NF-kappa-B by virus"
is_a: GO:0019056 ! modulation by virus of host transcription
is_a: GO:0039506 ! modulation by virus of host molecular function
created_by: rfoulger
creation_date: 2012-10-11T16:04:31Z

[Term]
id: GO:0039653
name: suppression by virus of host transcription
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the activity of host DNA-dependent transcription; the cellular synthesis of RNA on a template of DNA. Viral proteins can interfere with either host RNA polymerase or with transcription factors." [UniProtKB-KW:KW-1191, VZ:1577]
synonym: "host transcription shutoff by virus" NARROW [UniProtKB-KW:KW-1191, VZ:1577]
synonym: "suppression by virus of host DNA-dependent transcription" EXACT [GOC:bf]
xref: VZ:1577 "Host transcription shutoff by virus"
is_a: GO:0019056 ! modulation by virus of host transcription
is_a: GO:0039657 ! suppression by virus of host gene expression
created_by: rfoulger
creation_date: 2012-10-11T16:11:17Z

[Term]
id: GO:0039654
name: fusion of virus membrane with host endosome membrane
namespace: biological_process
alt_id: GO:0075501
alt_id: GO:0075517
def: "Fusion of a virus membrane with a host endosome membrane. Occurs after internalization of the virus through the endosomal pathway, and results in release of the virus contents into the cell." [GOC:bf, UniProtKB-KW:KW-1170, VZ:992]
synonym: "fusion of virus membrane with host endosomal membrane" EXACT [UniProtKB-KW:KW-1170, VZ:992]
synonym: "viral entry into host cell via caveolae-mediated endocytosis followed by membrane fusion with the endosome membrane" NARROW [GOC:bf, GOC:jl]
synonym: "viral entry into host cell via caveolin-mediated endocytosis followed by membrane fusion with the endosome membrane" NARROW []
synonym: "viral entry into host cell via clathrin-mediated endocytosis followed by membrane fusion with the endosome membrane" NARROW []
synonym: "viral entry into host cell via endocytosis followed by membrane fusion with host endosome" RELATED [GOC:bf, GOC:jl]
synonym: "viral entry into host cell via endocytosis followed by membrane fusion with the endosome membrane" RELATED [GOC:bf, GOC:jl]
synonym: "viral penetration via endocytosis followed by caveolae-mediated membrane fusion with the endosome membrane" NARROW []
synonym: "viral penetration via endocytosis followed by clathrin-mediated membrane fusion with the endosome membrane" NARROW []
xref: VZ:992 "Fusion of virus membrane with host endosomal membrane"
is_a: GO:0039663 ! membrane fusion involved in viral entry into host cell
created_by: rfoulger
creation_date: 2013-06-20T14:24:05Z

[Term]
id: GO:0039655
name: transport of virus in host, cell to cell via plasmodesmata
namespace: biological_process
def: "The transport of a virus between adjacent cells in a multicellular organism using plasmodesmata. Plasmodesma is a fine cytoplasmic channel found in all higher plants, which connects the cytoplasm of one cell to that of an adjacent cell." [UniProtKB-KW:KW-0916, VZ:1018]
subset: virus_checked
synonym: "spread of virus in host, cell to cell via plasmodesmata" RELATED [GOC:bf, GOC:jl]
synonym: "viral movement protein" RELATED [VZ:1018]
xref: VZ:1018 "Viral movement protein"
is_a: GO:0046740 ! transport of virus in host, cell to cell
is_a: GO:1902588 ! multi-organism plasmodesmata-mediated intercellular transport
created_by: rfoulger
creation_date: 2013-06-20T14:47:50Z

[Term]
id: GO:0039656
name: modulation by virus of host gene expression
namespace: biological_process
def: "The process in which a virus effects a change in gene expression in its host organism. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form." [GOC:bf]
subset: goslim_virus
subset: virus_checked
synonym: "regulation by virus of host gene expression" RELATED [GOC:bf]
is_a: GO:0010468 ! regulation of gene expression
is_a: GO:0019054 ! modulation by virus of host process
created_by: rfoulger
creation_date: 2013-06-20T15:28:26Z

[Term]
id: GO:0039657
name: suppression by virus of host gene expression
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of gene expression in the host organism. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form." [UniProtKB-KW:KW-1190, VZ:1582]
synonym: "host gene expression shutoff by virus" EXACT [UniProtKB-KW:KW-1190, VZ:1582]
xref: VZ:1582 "Host gene expression shutoff by virus"
is_a: GO:0010629 ! negative regulation of gene expression
is_a: GO:0039656 ! modulation by virus of host gene expression
created_by: rfoulger
creation_date: 2013-06-20T15:29:55Z

[Term]
id: GO:0039658
name: TBK1-IKKE-DDX3 complex
namespace: cellular_component
def: "A protein complex containing TBK1 (TANK-binding kinase 1), IKBKE (I-Kappa-B kinase epsilon/IKKE/IKK-epsilon) and the DEAD box family RNA helicase DDX3." [PMID:18636090, VZ:719]
synonym: "TBK1-IKBKE-DDX3 complex" EXACT [VZ:719]
is_a: GO:0043234 ! protein complex
created_by: rfoulger
creation_date: 2013-07-03T16:59:27Z

[Term]
id: GO:0039659
name: suppression by virus of host TBK1-IKBKE-DDX3 complex activity
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the activity of the host TBK1-IKBKE-DDX3 complex." [VZ:719]
comment: See also: suppression by virus of host TBK1 activity ; GO:0039723, and suppression by virus of host IKBKE activity ; GO:0039724.
synonym: "inhibition of host TBK1-IKBKE-DDX3 complex by virus" EXACT [VZ:719]
synonym: "suppression by virus of host TBK1-IKKE-DDX3 complex activity" EXACT []
xref: VZ:719 "Inhibition of host TBK1-IKBKE-DDX3 complex by virus"
is_a: GO:0019048 ! modulation by virus of host morphology or physiology
created_by: rfoulger
creation_date: 2013-07-15T15:10:39Z

[Term]
id: GO:0039660
name: structural constituent of virion
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of a virion." [GOC:bf, GOC:jl]
synonym: "viral matrix protein" NARROW [UniProtKB-KW:KW-0468]
is_a: GO:0005198 ! structural molecule activity
created_by: rfoulger
creation_date: 2013-07-22T16:43:41Z

[Term]
id: GO:0039661
name: host organelle outer membrane
namespace: cellular_component
def: "The outer, i.e. cytoplasm-facing in a cellular organelle, lipid bilayer of an organelle envelope, occurring in a host cell." [GOC:bf, GOC:ch]
is_a: GO:0044384 ! host outer membrane
created_by: rfoulger
creation_date: 2013-08-25T10:44:43Z

[Term]
id: GO:0039662
name: host cell outer membrane
namespace: cellular_component
def: "A lipid bilayer that forms the outermost layer of the cell envelope, occurring in a host cell." [GOC:bf, GOC:ch]
synonym: "host cell envelope outer membrane" EXACT [GOC:bf, GOC:ch]
synonym: "outer membrane of host cell" EXACT [GOC:bf, GOC:ch]
is_a: GO:0044384 ! host outer membrane
relationship: part_of GO:0044230 ! host cell envelope
created_by: rfoulger
creation_date: 2013-08-25T10:48:41Z

[Term]
id: GO:0039663
name: membrane fusion involved in viral entry into host cell
namespace: biological_process
def: "Merging of the virion membrane and a host membrane (host plasma membrane or host organelle membrane) that is involved in the uptake of a virus into a host cell." [GOC:bf, GOC:jl, UniProtKB-KW:KW-1168]
synonym: "fusion of virus membrane with host membrane" RELATED [UniProtKB-KW:KW-1168]
synonym: "fusion of virus membrane with host membrane during viral entry" RELATED [UniProtKB-KW:KW-1168]
synonym: "viral entry into host cell via membrane fusion" RELATED [GOC:bf, GOC:jl]
is_a: GO:0044800 ! multi-organism membrane fusion
intersection_of: GO:0061025 ! membrane fusion
intersection_of: part_of GO:0046718 ! viral entry into host cell
relationship: part_of GO:0046718 ! viral entry into host cell
created_by: rfoulger
creation_date: 2013-08-29T10:15:11Z

[Term]
id: GO:0039664
name: lysis of host organelle involved in viral entry into host cell
namespace: biological_process
def: "The viral-induced lysis of an organelle (endosome, lysosome, or caveosome) that is involved in the uptake of a virus into a host cell. Occurs once the virus is within the organelle, and results in transfer of the viral contents from the organelle compartment into the cytoplasm." [GOC:bf, GOC:jl, UniProtKB-KW:KW-1174, VZ:984]
synonym: "viral entry into host cell via endosome membrane lysis" NARROW [VZ:984]
synonym: "viral entry into host cell via lysis of host organelle membrane" RELATED [GOC:bf, GOC:jl]
synonym: "viral membrane-lytic protein" RELATED [UniProtKB-KW:KW-1174]
synonym: "viral penetration via lysis of host organellar membrane" EXACT [UniProtKB-KW:KW-984]
xref: VZ:984 "Viral penetration via lysis of host organellar membrane"
is_a: GO:0016032 ! viral process
relationship: has_part GO:0044662 ! disruption by virus of host cell membrane
relationship: part_of GO:0046718 ! viral entry into host cell
created_by: rfoulger
creation_date: 2013-08-29T11:30:18Z

[Term]
id: GO:0039665
name: permeabilization of host organelle membrane involved in viral entry into host cell
namespace: biological_process
def: "Induction of organellar membrane permeabilization triggered by an interaction between the host membrane and a membrane-penetration protein associated with a viral capsid. Results in release of the virus contents from an organelle into the host cell cytoplasm." [GOC:bf, GOC:jl, UniProtKB-KW:KW-1173, VZ:985]
synonym: "viral entry into host cell via permeabilization of host organelle membrane" RELATED [GOC:bf, GOC:jl]
synonym: "viral membrane-penetration protein" RELATED [UniProtKB-KW:KW-1173]
synonym: "viral penetration via host endosomal membrane disruption by virus" EXACT [UniProtKB-KW:KW-1173]
synonym: "viral penetration via perforation of host organellar membrane by virus" EXACT [UniProtKB-KW:KW-1173]
synonym: "viral penetration via permeabilization of host organellar membrane" EXACT [UniProtKB-KW:KW-1173, VZ:985]
xref: VZ:985 "Viral penetration via permeabilization of host organellar membrane"
is_a: GO:0016032 ! viral process
relationship: part_of GO:0046718 ! viral entry into host cell
created_by: rfoulger
creation_date: 2013-08-29T11:57:21Z

[Term]
id: GO:0039666
name: virion attachment to host cell pilus
namespace: biological_process
def: "The process by which a virion attaches to a host cell by binding to a pilus on the host cell surface. Pili are retractile filaments that protrude from gram-negative bacteria. Filamentous viruses can attach to the pilus tip, whereas icosahedral viruses can attach to the pilus side." [UniProtKB-KW:KW-1175, VZ:981]
subset: virus_checked
synonym: "pilus-adsorption protein" EXACT [PMID:16298408]
synonym: "pilus-mediated viral adsorption onto host cell" RELATED [UniProtKB-KW:KW-1175, VZ:981]
synonym: "pilus-mediated viral attachment to host cell" RELATED [GOC:bf, GOC:jl]
synonym: "viral attachment to host cell pilus" RELATED [GOC:bf, GOC:jl]
xref: VZ:981 "Pilus-mediated viral adsorption onto host cell"
is_a: GO:0019062 ! virion attachment to host cell
created_by: rfoulger
creation_date: 2013-08-29T13:31:10Z

[Term]
id: GO:0039667
name: viral entry into host cell via pilus retraction
namespace: biological_process
def: "The uptake of a virus or viral genetic material into a host cell which occurs through retraction of a virion-bound pilus." [GOC:bf, GOC:jl, VZ:981]
comment: This method of entry into the cell differs between viruses; filamentous bacteriophages have rod-shaped virions which attach to the tip of the pilus; after retraction of the pilus with the virion attached, the genome can enter the host cell through the pilus basal pore. For icosahedral viruses, retraction of the pilus brings the virus in contact with the cell membrane and the genome can enter the cell via membrane fusion or genome injection. In GO, viral entry begins after viral attachment; for pilus-attachment proteins see instead: viral attachment to host cell pilus ; GO:0039666.
is_a: GO:0046718 ! viral entry into host cell
relationship: has_part GO:0043108 ! pilus retraction
relationship: has_part GO:0046794 ! transport of virus
created_by: rfoulger
creation_date: 2013-09-04T14:32:19Z

[Term]
id: GO:0039668
name: viral entry into host cell via pilus basal pore
namespace: biological_process
def: "The uptake of a virus or viral genetic material into a host cell which occurs through retraction of the virion-bound pilus, followed by entry of the viral genome into the host cell through the pilus basal pore. Filamentous bacteriophages absorb to the tip of the F-pili and can enter the bacterial cell in this way." [GOC:bf, GOC:jl]
synonym: "filamentous viral entry into host cell via pilus retraction" NARROW [GOC:bf, GOC:jl, VZ:981]
is_a: GO:0039667 ! viral entry into host cell via pilus retraction
created_by: rfoulger
creation_date: 2013-09-04T14:33:18Z

[Term]
id: GO:0039669
name: viral entry into host cell via pilus retraction and membrane fusion
namespace: biological_process
def: "The uptake of a virus into a host cell which occurs via retraction of the viral-bound pilus to bring the virus in contact with the host cell membrane, followed by fusion of the bacteriophage membrane with the host outer membrane." [GOC:bf, GOC:jl, PMID:20427561, VZ:981]
comment: For annotation of viral pilus-binding proteins, see also 'viral attachment to host cell pilus ; GO:0039666'.
is_a: GO:0039667 ! viral entry into host cell via pilus retraction
relationship: has_part GO:0019064 ! fusion of virus membrane with host plasma membrane
created_by: rfoulger
creation_date: 2013-09-04T14:35:44Z

[Term]
id: GO:0039670
name: viral capsid, turret
namespace: cellular_component
def: "A turret-like appendage formed at the vertices of an icosahedral capsid." [GOC:jh2, PMID:20592081]
is_a: GO:0098021 ! viral capsid, decoration
relationship: part_of GO:0019030 ! icosahedral viral capsid
created_by: rfoulger
creation_date: 2013-09-25T10:08:14Z

[Term]
id: GO:0039671
name: evasion by virus of host natural killer cell activity
namespace: biological_process
def: "Any process by which a virus avoids the effects mediated by the host organism's natural killer (NK) cells." [GOC:bf, GOC:jl, PMID:15640804, PMID:18688275, UniProtKB-KW:KW-1131]
synonym: "evasion by virus of host natural killer cell response" EXACT []
synonym: "evasion by virus of host NK cell killing" EXACT [GOC:bf]
synonym: "modulation of host NK-cell activity by virus" RELATED [UniProtKB-KW:KW-1131]
synonym: "protection by virus against host NK cell cytotoxicity" EXACT [PMID:12782710]
synonym: "suppression by virus of host natural killer cell function" EXACT [PMID:15640804]
synonym: "viral immunoevasion of host NK cell" EXACT [GOC:bf]
is_a: GO:0030683 ! evasion or tolerance by virus of host immune response
created_by: rfoulger
creation_date: 2013-09-25T11:04:53Z

[Term]
id: GO:0039672
name: suppression by virus of host natural killer cell activation
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of natural killer cell activation in the host." [GOC:bf, GOC:jl]
synonym: "suppression by virus of host NK-cell activation" EXACT [GOC:bf, GOC:jl]
is_a: GO:0032815 ! negative regulation of natural killer cell activation
is_a: GO:0039671 ! evasion by virus of host natural killer cell activity
created_by: rfoulger
creation_date: 2013-09-25T11:08:19Z

[Term]
id: GO:0039673
name: evasion by virus of host dendritic cell activity
namespace: biological_process
def: "Any process by which a virus avoids the effects mediated by the host organism's dendritic cells." [GOC:bf, GOC:jl, UniProtKB-KW:KW-1118]
synonym: "evasion by virus of host dendritic cell response" EXACT []
synonym: "impairing dendritic cell function by virus" EXACT [UniProtKB-KW:KW-1118]
synonym: "modulation of host dendritic cell activity by virus" BROAD [UniProtKB-KW:KW-1118]
is_a: GO:0030683 ! evasion or tolerance by virus of host immune response
created_by: rfoulger
creation_date: 2013-09-25T11:18:51Z

[Term]
id: GO:0039674
name: exit of virus from host cell nucleus
namespace: biological_process
def: "The directed movement of the viral genome or a viral particle out of the host cell nucleus." [VZ:2177]
subset: goslim_virus
subset: virus_checked
xref: VZ:2177 "Nuclear exit of viral genome"
is_a: GO:0051168 ! nuclear export
is_a: GO:0075733 ! intracellular transport of virus
created_by: rfoulger
creation_date: 2013-09-25T13:59:41Z

[Term]
id: GO:0039675
name: exit of virus from host cell nucleus through nuclear pore
namespace: biological_process
def: "The directed movement of the viral genome or a viral particle out of the host cell nucleus through the nuclear pore." [PMID:12921991, VZ:1953]
subset: virus_checked
synonym: "exit of virus from host cell nucleus through nuclear pore complex" EXACT []
synonym: "nuclear pore exit of virus" EXACT [VZ:1953]
synonym: "viral enome export through nuclear pore" EXACT [VZ:1953]
xref: VZ:1953 "Genome export through nuclear pore"
is_a: GO:0039674 ! exit of virus from host cell nucleus
created_by: rfoulger
creation_date: 2013-09-25T14:10:03Z

[Term]
id: GO:0039677
name: exit of virus from host cell nucleus via nuclear envelope disassembly
namespace: biological_process
def: "The directed movement of the viral genome or a viral particle out of the host cell nucleus that involves disruption of the nuclear membrane envelope by the virus." [VZ:2176]
subset: virus_checked
synonym: "exit of virus from host cell nucleus via nuclear envelope breakdown" EXACT [VZ:2176]
xref: VZ:2176 "Nuclear envelope breakdown"
is_a: GO:0039674 ! exit of virus from host cell nucleus
relationship: has_part GO:0051081 ! nuclear envelope disassembly
created_by: rfoulger
creation_date: 2013-09-25T14:10:03Z

[Term]
id: GO:0039678
name: viral genome ejection through host cell envelope
namespace: biological_process
def: "Ejection by a non-enveloped prokaryotic virus of its genome into the host cytoplasm. Caudovirales carry an ejection apparatus that can be long and contractile, long and noncontractile, or short, and is able to penetrate the host cell envelope to deliver the viral genome into the host cell cytoplasm." [GOC:ch, PMID:23385786, UniProtKB-KW:KW-1171]
comment: When a pore-forming protein is involved, see also 'pore-mediated entry of viral genome into host cell ; GO:0044694'.
synonym: "phage genome ejection" NARROW [PMID:23385786]
synonym: "viral genome injection through bacterial membranes" NARROW [UniProtKB-KW:KW-1171]
is_a: GO:0046718 ! viral entry into host cell
is_a: GO:0046794 ! transport of virus
created_by: rfoulger
creation_date: 2013-09-26T11:56:48Z

[Term]
id: GO:0039679
name: viral occlusion body
namespace: cellular_component
def: "A crystalline protein matrix surrounding the nucleocapsids of some insect viruses after their release in the environment. Produced in the host cell, the occlusion body protects the infectious virion after death of the host." [UniProtKB-KW:KW-0842, VZ:1949]
xref: VZ:1949 "Occlusion bodies"
is_a: GO:0005575 ! cellular_component
relationship: has_part GO:0019012 ! virion
created_by: rfoulger
creation_date: 2013-09-26T14:17:10Z

[Term]
id: GO:0039680
name: actin-dependent intracellular transport of virus towards nucleus
namespace: biological_process
def: "The directed movement of a virus, or part of a virus, towards the host cell nucleus using actin filaments." [UniProtKB-KW:KW-1178, VZ:991]
subset: virus_checked
synonym: "actin-dependent intracellular transport of viral material towards nucleus" EXACT []
synonym: "actin-dependent inwards viral transport" EXACT [VZ:991]
xref: VZ:991 "Actin-dependent inwards viral transport"
is_a: GO:0075520 ! actin-dependent intracellular transport of virus
is_a: GO:0075606 ! transport of viral material towards nucleus
created_by: rfoulger
creation_date: 2013-10-10T11:24:56Z

[Term]
id: GO:0039682
name: rolling circle viral DNA replication
namespace: biological_process
def: "A process of unidirectional viral DNA replication that takes place on a circular DNA to rapidly produce numerous copies of the viral genome. Involves creating a nick in one strand of the circular DNA molecule at the origin of replication. DNA is then synthesized by DNA polymerase. Using the non-nicked strand as a template, replication proceeds around the circular DNA molecule, displacing the nicked strand as single-stranded DNA." [GOC:bf, GOC:jl, VZ:915, Wikipedia:Rolling_circle_replication]
subset: virus_checked
is_a: GO:0039687 ! viral DNA strand displacement replication
is_a: GO:0070581 ! rolling circle DNA replication
created_by: rfoulger
creation_date: 2013-10-17T14:13:51Z

[Term]
id: GO:0039683
name: rolling circle double-stranded viral DNA replication
namespace: biological_process
def: "A rolling circle viral DNA replication that begins with a double-stranded viral DNA genome." [GOC:bf, GOC:jl, VZ:2676]
subset: virus_checked
synonym: "dsDNA rolling circle replication" EXACT [VZ:2676]
xref: VZ:2676 "dsDNA rolling circle replication"
is_a: GO:0039682 ! rolling circle viral DNA replication
created_by: rfoulger
creation_date: 2013-10-17T14:15:04Z

[Term]
id: GO:0039684
name: rolling circle single-stranded viral DNA replication
namespace: biological_process
def: "A rolling circle viral DNA replication that begins with a single-stranded viral DNA genome." [GOC:bf, GOC:jl, VZ:1941]
subset: virus_checked
synonym: "ssDNA rolling circle replication" EXACT [VZ:1941]
xref: VZ:1941 "ssDNA Rolling circle"
is_a: GO:0039682 ! rolling circle viral DNA replication
created_by: rfoulger
creation_date: 2013-10-17T14:15:48Z

[Term]
id: GO:0039685
name: rolling hairpin viral DNA replication
namespace: biological_process
def: "A viral DNA replication process where a 3' hairpin structure in the viral single-stranded DNA (ssDNA) template serves as a primer for host enzymes to synthesize DNA." [GOC:bf, GOC:jl, VZ:2656]
synonym: "ssDNA rolling hairpin viral DNA replication" EXACT [VZ:2656]
xref: VZ:2656 "Rolling hairpin replication"
is_a: GO:0039693 ! viral DNA genome replication
created_by: rfoulger
creation_date: 2013-10-17T14:33:55Z

[Term]
id: GO:0039686
name: bidirectional double-stranded viral DNA replication
namespace: biological_process
def: "A viral DNA replication process where replication occurs in both directions from the starting point. This creates two replication forks, moving in opposite directions." [GOC:bf, GOC:jl, VZ:1939]
subset: virus_checked
synonym: "viral bidirectional dsDNA replication" EXACT [VZ:1939]
xref: VZ:1939 "dsDNA bidirectional replication"
is_a: GO:0039693 ! viral DNA genome replication
created_by: rfoulger
creation_date: 2013-10-17T14:42:09Z

[Term]
id: GO:0039687
name: viral DNA strand displacement replication
namespace: biological_process
def: "A viral DNA replication process where only one strand is replicated at once, and which releases a single stranded DNA (ssDNA)." [GOC:bf, GOC:jl, VZ:1940]
subset: virus_checked
xref: VZ:1940 "DNA strand displacement replication"
is_a: GO:0039693 ! viral DNA genome replication
created_by: rfoulger
creation_date: 2013-10-17T14:48:40Z

[Term]
id: GO:0039688
name: viral double stranded DNA replication via reverse transcription
namespace: biological_process
def: "A DNA replication process that uses viral RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands." [GOC:bf, GOC:jl, VZ:1938]
subset: virus_checked
synonym: "dsDNA replication via RNA intermediate" EXACT [GOC:bf, GOC:jl]
synonym: "RNA-dependent viral DNA replication" RELATED [GOC:bf, GOC:jl]
synonym: "viral RNA-dependent DNA replication" EXACT [GOC:bf, GOC:jl]
xref: VZ:1938 "dsDNA(RT) replication/transcription"
is_a: GO:0016070 ! RNA metabolic process
is_a: GO:0039693 ! viral DNA genome replication
relationship: has_part GO:0001171 ! reverse transcription
relationship: has_part GO:0039695 ! DNA-templated viral transcription
created_by: rfoulger
creation_date: 2013-10-17T15:00:08Z

[Term]
id: GO:0039689
name: negative stranded viral RNA replication
namespace: biological_process
def: "A viral genome replication process where the template genome is negative stranded, single stranded RNA ((-)ssRNA)." [GOC:bf, GOC:jl, VZ:1096]
subset: virus_checked
synonym: "(-)ss viral RNA replication" EXACT [VZ:1096]
xref: VZ:1096 "Negative stranded RNA virus replication"
is_a: GO:0032774 ! RNA biosynthetic process
is_a: GO:0039694 ! viral RNA genome replication
is_a: GO:0044034 ! multi-organism biosynthetic process
relationship: has_part GO:0039696 ! RNA-templated viral transcription
created_by: rfoulger
creation_date: 2013-10-17T15:40:27Z

[Term]
id: GO:0039690
name: positive stranded viral RNA replication
namespace: biological_process
def: "A viral genome replication process where the template genome is positive stranded, single stranded RNA ((+)ssRNA). Replication of the positive strand leads to dsRNA formation, which in turn is transcribed into positive single stranded RNA." [GOC:bf, GOC:jl, VZ:1116]
subset: virus_checked
synonym: "ss(+) viral RNA replication" RELATED [VZ:1116]
xref: VZ:1116 "Positive stranded RNA virus replication"
is_a: GO:0032774 ! RNA biosynthetic process
is_a: GO:0039694 ! viral RNA genome replication
is_a: GO:0044034 ! multi-organism biosynthetic process
created_by: rfoulger
creation_date: 2013-10-17T15:45:40Z

[Term]
id: GO:0039691
name: double stranded viral RNA replication
namespace: biological_process
def: "A viral genome replication process where the template genome is double stranded RNA (dsRNA). Genomic dsRNA is first transcribed into single-stranded (ss) mRNA, which is then replicated to ds-genomic RNA." [GOC:bf, GOC:jl, VZ:1936]
subset: virus_checked
xref: VZ:1936 "Double-stranded RNA virus replication"
is_a: GO:0032774 ! RNA biosynthetic process
is_a: GO:0039694 ! viral RNA genome replication
is_a: GO:0044034 ! multi-organism biosynthetic process
relationship: has_part GO:0039696 ! RNA-templated viral transcription
created_by: rfoulger
creation_date: 2013-10-17T15:52:19Z

[Term]
id: GO:0039692
name: single stranded viral RNA replication via double stranded DNA intermediate
namespace: biological_process
alt_id: GO:0045090
def: "A viral genome replication where the template is single-stranded RNA (ssRNA), and which proceeds via a double stranded DNA (dsDNA) intermediate molecule. Viral genomic RNA is first reverse transcribed into dsDNA, which integrates into the host chromosomal DNA, where it is transcribed by host RNA polymerase II." [GOC:bf, GOC:jl, ISBN:0198506732, VZ:1937]
synonym: "retroviral genome replication" EXACT []
synonym: "viral ssRNA replication via dsDNA intermediate" RELATED [GOC:bf]
xref: VZ:1937 "ssRNA(RT) replication/transcription"
is_a: GO:0006259 ! DNA metabolic process
is_a: GO:0039694 ! viral RNA genome replication
relationship: has_part GO:0001171 ! reverse transcription
relationship: has_part GO:0039695 ! DNA-templated viral transcription
relationship: has_part GO:0044826 ! viral genome integration into host DNA
created_by: rfoulger
creation_date: 2013-10-17T15:59:43Z

[Term]
id: GO:0039693
name: viral DNA genome replication
namespace: biological_process
alt_id: GO:0039681
def: "The replication of a viral DNA genome." [GOC:bf, GOC:jl, VZ:915]
subset: virus_checked
synonym: "DNA-dependent viral DNA replication" EXACT [GOC:bf, GOC:jl]
synonym: "viral DNA replication" EXACT [GOC:bf, GOC:jl]
synonym: "viral DNA-dependent DNA replication" EXACT []
is_a: GO:0006261 ! DNA-dependent DNA replication
is_a: GO:0019079 ! viral genome replication
is_a: GO:0044034 ! multi-organism biosynthetic process
created_by: rfoulger
creation_date: 2013-10-23T15:22:31Z

[Term]
id: GO:0039694
name: viral RNA genome replication
namespace: biological_process
def: "The replication of a viral RNA genome." [GOC:bf, GOC:jl]
subset: virus_checked
is_a: GO:0019079 ! viral genome replication
is_a: GO:0039703 ! RNA replication
is_a: GO:0044033 ! multi-organism metabolic process
created_by: rfoulger
creation_date: 2013-10-23T15:24:36Z

[Term]
id: GO:0039695
name: DNA-templated viral transcription
namespace: biological_process
def: "A transcription process that uses a viral DNA as a template." [GOC:bf, GOC:jl]
xref: VZ:1942 "dsDNA templated transcription"
is_a: GO:0006351 ! transcription, DNA-templated
is_a: GO:0019083 ! viral transcription
created_by: rfoulger
creation_date: 2013-10-28T13:25:20Z

[Term]
id: GO:0039696
name: RNA-templated viral transcription
namespace: biological_process
def: "A transcription process that uses viral RNA as a template." [GOC:bf, GOC:jl]
is_a: GO:0001172 ! transcription, RNA-templated
is_a: GO:0019083 ! viral transcription
created_by: rfoulger
creation_date: 2013-10-28T13:28:01Z

[Term]
id: GO:0039697
name: negative stranded viral RNA transcription
namespace: biological_process
def: "A viral transcription process that uses negative stranded (-) single stranded (ss) RNA as a template." [VZ:1096]
xref: VZ:1096 "Negative stranded RNA virus replication"
is_a: GO:0039696 ! RNA-templated viral transcription
created_by: rfoulger
creation_date: 2013-10-28T14:41:41Z

[Term]
id: GO:0039698
name: polyadenylation of viral mRNA by polymerase stuttering
namespace: biological_process
def: "Polyadenylation of viral mRNA through a polymerase stuttering mechanism. The stop signal present at the end of each gene comprises a stretch of uridine on which the viral polymerase acquires a stuttering behavior: after each adenine inserted, the polymerase moves back one nucleotide along with the mRNA. It resumes transcription adding a new adenine, then again moves back, thereby producing a polyA tail." [VZ:1916]
synonym: "polyA stuttering" EXACT [VZ:1916]
xref: VZ:1916 "Negative-stranded RNA virus Polymerase stuttering"
is_a: GO:0043631 ! RNA polyadenylation
created_by: rfoulger
creation_date: 2013-10-28T14:54:07Z

[Term]
id: GO:0039699
name: viral mRNA cap methylation
namespace: biological_process
def: "Methylation of the 2'-O-ribose of the first or second transcribed nucleotide of a viral mRNA. Methylation allows evasion of the host innate immune response, which degrades cap0 (non-methylated) mRNAs." [UniProtKB-KW:KW-1196]
synonym: "IFIT mRNA restriction evasion by virus" EXACT [UniProtKB-KW:KW-1196]
is_a: GO:0036451 ! cap mRNA methylation
is_a: GO:0039503 ! suppression by virus of host innate immune response
is_a: GO:0044033 ! multi-organism metabolic process
created_by: rfoulger
creation_date: 2013-11-06T14:39:17Z

[Term]
id: GO:0039700
name: fusion of viral membrane with host outer nuclear membrane
namespace: biological_process
def: "Fusion of a viral primary envelope with the host outer nuclear membrane during nuclear egress. The transitory primary envelope is acquired by the virus as it buds at the inner nuclear membrane and gains access to the perinuclear space. This membrane is lost by fusing with the host outer nuclear membrane during nuclear exit." [PMID:23057731, UniProtKB-KW:KW-1181]
synonym: "fusion of viral membrane with host outer nuclear membrane involved in nuclear egress" EXACT [GOC:bf]
synonym: "viral primary envelope fusion with host outer nuclear membrane" EXACT [UniProtKB-KW:KW-1181]
is_a: GO:0044800 ! multi-organism membrane fusion
relationship: part_of GO:0046802 ! exit of virus from host cell nucleus by nuclear egress
created_by: rfoulger
creation_date: 2013-11-06T15:07:46Z

[Term]
id: GO:0039701
name: microtubule-dependent intracellular transport of viral material towards cell periphery
namespace: biological_process
def: "The directed movement of the viral genome or a viral particle towards the cell periphery using host microtubules. Mostly used by viruses that replicate their genome near or in the nucleus to allows newly assembled viral progeny to reach the plasma membrane." [UniProtKB-KW:KW-1189, VZ:1816]
subset: virus_checked
xref: VZ:1816 "Microtubular outwards viral transport"
is_a: GO:0075519 ! microtubule-dependent intracellular transport of viral material
created_by: rfoulger
creation_date: 2013-11-06T16:09:57Z

[Term]
id: GO:0039702
name: viral budding via host ESCRT complex
namespace: biological_process
def: "Viral budding which uses a host ESCRT protein complex, or complexes, to mediate the budding process." [UniProtKB-KW:KW-1187, VZ:1536]
synonym: "host-assisted viral budding" BROAD [VZ:1536]
synonym: "viral budding through the ESCRT machinery" RELATED [VZ:1536]
xref: VZ:1536 "Viral budding via the host ESCRT complexes"
is_a: GO:0046755 ! viral budding
created_by: rfoulger
creation_date: 2013-11-06T16:51:53Z

[Term]
id: GO:0039703
name: RNA replication
namespace: biological_process
def: "The cellular metabolic process in which a cell duplicates one or more molecules of RNA." [GOC:bf, GOC:jl]
subset: virus_checked
is_a: GO:0016070 ! RNA metabolic process
relationship: has_part GO:0032774 ! RNA biosynthetic process
created_by: rfoulger
creation_date: 2013-11-21T16:53:29Z

[Term]
id: GO:0039704
name: viral translational shunt
namespace: biological_process
def: "A viral translation initiation mechanism where ribosomes are loaded onto viral mRNA at the 5'-cap structure and start scanning for a short distance before by-passing the large internal leader region and initiating at a downstream start site." [PMID:15827182, PMID:18195037, VZ:608]
comment: This term is intended to annotate gene products involved in the process of viral translational shunt, not viral proteins produced by this translation process.
synonym: "ribosomal shunt initiation pathway" EXACT [PMID:18195037]
xref: VZ:608 "Ribosomal shunt"
is_a: GO:0019081 ! viral translation
created_by: rfoulger
creation_date: 2013-11-21T17:08:40Z

[Term]
id: GO:0039705
name: viral translational readthrough
namespace: biological_process
def: "The continuation of translation of a viral mRNA beyond a stop codon by the use of a special tRNA that recognizes the UAG and UGA codons as modified amino acids, rather than as termination codons." [GOC:bf, GOC:ch, GOC:jl, PMID:10839817, VZ:859]
comment: This term is intended to annotate gene products involved in the process of viral translational readthrough, not viral proteins produced by this translation process.
synonym: "viral RNA suppression of termination" RELATED [VZ:859]
synonym: "viral stop codon readthrough" EXACT [VZ:859]
xref: VZ:859 "RNA suppression of termination"
is_a: GO:0006451 ! translational readthrough
relationship: part_of GO:0019081 ! viral translation
created_by: rfoulger
creation_date: 2013-11-25T13:20:37Z

[Term]
id: GO:0039706
name: co-receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a coreceptor. A coreceptor acts in cooperation with a primary receptor to transmit a signal within the cell." [GOC:bf, GOC:jl]
is_a: GO:0005515 ! protein binding
created_by: rfoulger
creation_date: 2013-11-25T14:41:42Z

[Term]
id: GO:0039707
name: pore formation by virus in membrane of host cell
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components by a virus to form a pore complex in a membrane of a host organism." [GOC:bf, GOC:jl, PMID:12972148, UniProtKB-KW:KW-1182]
subset: goslim_virus
synonym: "pore formation in membrane of host cell by virus" EXACT [GOC:bf]
synonym: "viroporin" RELATED [PMID:12972148, UniProtKB-KW:KW-1182]
is_a: GO:0016032 ! viral process
is_a: GO:0044658 ! pore formation in membrane of host by symbiont
created_by: rfoulger
creation_date: 2013-11-25T15:33:33Z

[Term]
id: GO:0039708
name: nuclear capsid assembly
namespace: biological_process
def: "The assembly of a virus capsid that occurs in the nucleus. The assembly of large icosahedral shells for herpesviridae and adenoviridae requires structural proteins that act as chaperones for assembly." [VZ:1516]
subset: virus_checked
xref: VZ:1516 "Nuclear capsid assembly"
is_a: GO:0019069 ! viral capsid assembly
intersection_of: GO:0019069 ! viral capsid assembly
intersection_of: occurs_in GO:0005634 ! nucleus
relationship: occurs_in GO:0005634 ! nucleus
created_by: rfoulger
creation_date: 2013-11-28T15:08:41Z

[Term]
id: GO:0039709
name: cytoplasmic capsid assembly
namespace: biological_process
def: "The assembly of a virus capsid that occurs in the cytoplasm." [VZ:1950]
xref: VZ:1950 "Cytoplasmic capsid assembly/packaging"
is_a: GO:0019069 ! viral capsid assembly
intersection_of: GO:0019069 ! viral capsid assembly
intersection_of: occurs_in GO:0005737 ! cytoplasm
relationship: occurs_in GO:0005737 ! cytoplasm
created_by: rfoulger
creation_date: 2013-11-28T15:12:30Z

[Term]
id: GO:0039710
name: cytoplasmic icosahedral capsid assembly
namespace: biological_process
def: "The assembly of an icosahedral viral capsid in the cytoplasm. Often occurs by assembling around the viral genome." [VZ:1950]
subset: virus_checked
is_a: GO:0039709 ! cytoplasmic capsid assembly
created_by: rfoulger
creation_date: 2013-11-28T15:20:50Z

[Term]
id: GO:0039711
name: cytoplasmic helical capsid assembly
namespace: biological_process
def: "The assembly of a helical viral capsid in the cytoplasm. Occurs by assembling around the viral genome." [VZ:1950]
is_a: GO:0039709 ! cytoplasmic capsid assembly
created_by: rfoulger
creation_date: 2013-11-28T15:23:39Z

[Term]
id: GO:0039712
name: induction by virus of host catalytic activity
namespace: biological_process
def: "Any viral process that activates or increases the frequency, rate or extent of host catalytic activity." [GOC:bf, GOC:jl]
synonym: "induction by virus of host enzyme activity" EXACT [GOC:bf, GOC:jl]
is_a: GO:0039516 ! modulation by virus of host catalytic activity
is_a: GO:0043948 ! positive regulation by symbiont of host catalytic activity
created_by: rfoulger
creation_date: 2013-12-19T13:21:45Z

[Term]
id: GO:0039713
name: viral factory
namespace: cellular_component
def: "An intracellular compartment in a host cell which increases the efficiency of viral replication and/or assembly, and shields the virus from host defenses. Viral factories can be either cytoplasmic or nuclear and often arise from extensive rearrangement of host cell cytoskeletal and/or cell membrane compartments." [PMID:22440839, VZ:1951]
synonym: "virus factory" EXACT [PMID:22440839]
xref: VZ:1951 "Viral factories"
is_a: GO:0033643 ! host cell part
created_by: rfoulger
creation_date: 2013-12-19T14:53:47Z

[Term]
id: GO:0039714
name: cytoplasmic viral factory
namespace: cellular_component
def: "A viral factory located in the cytoplasm of a host cell." [VZ:1951]
is_a: GO:0033655 ! host cell cytoplasm part
is_a: GO:0039713 ! viral factory
intersection_of: GO:0039713 ! viral factory
intersection_of: part_of GO:0030430 ! host cell cytoplasm
relationship: part_of GO:0030430 ! host cell cytoplasm
created_by: rfoulger
creation_date: 2013-12-19T15:16:15Z

[Term]
id: GO:0039715
name: nuclear viral factory
namespace: cellular_component
def: "A viral factory located in the nucleus of a host cell." [VZ:1951]
is_a: GO:0039713 ! viral factory
intersection_of: GO:0039713 ! viral factory
intersection_of: part_of GO:0042025 ! host cell nucleus
relationship: part_of GO:0042025 ! host cell nucleus
created_by: rfoulger
creation_date: 2013-12-19T15:18:07Z

[Term]
id: GO:0039716
name: viroplasm viral factory
namespace: cellular_component
def: "A cytoplasmic viral factory that is electron dense due to high levels of viral RNA. Produced by nucleo-cytoplasmic large DNA viruses (NCLDV) like Poxviridae, Asfarviridae and Iridoviridae, and dsRNA viruses like Reoviridae." [VZ:1951, Wikipedia:Viroplasm]
xref: Wikipedia:Viroplasm
is_a: GO:0039714 ! cytoplasmic viral factory
created_by: rfoulger
creation_date: 2013-12-19T15:22:29Z

[Term]
id: GO:0039717
name: spherule viral factory
namespace: cellular_component
def: "A cytoplasmic viral factory which is a 50-400nm diameter membrane invagination. Spherules can appear on several enveloped cellular components depending on the virus." [VZ:1951]
xref: Wikipedia:Viroplasm
is_a: GO:0039714 ! cytoplasmic viral factory
created_by: rfoulger
creation_date: 2013-12-19T15:25:57Z

[Term]
id: GO:0039718
name: double membrane vesicle viral factory
namespace: cellular_component
def: "A cytoplasmic viral factory that consists of a double-membrane bound vesicle. Has a diameter of 200-300nm and is derived from the endoplasmic reticulum or Golgi apparatus. Produced by Picornaviridae, Nidovirales, Arteriviridae and Coronaviridae." [PMID:22440839, VZ:1951]
synonym: "DMV viral factory" EXACT [VZ:1951]
is_a: GO:0039714 ! cytoplasmic viral factory
created_by: rfoulger
creation_date: 2013-12-19T15:31:22Z

[Term]
id: GO:0039719
name: tube viral factory
namespace: cellular_component
def: "A cytoplasmic viral factory derived from the Golgi in which Bunyaviridae replication takes place. Tubes are membranous structures close to the assembly and budding sites, and their function may be to connect viral replication and morphogenesis inside viral factories." [VZ:1951]
is_a: GO:0039714 ! cytoplasmic viral factory
created_by: rfoulger
creation_date: 2013-12-19T15:34:56Z

[Term]
id: GO:0039720
name: virogenic stroma
namespace: cellular_component
def: "A nuclear viral factory formed by Baculoviruses. A vesicular structure in which virions are assembled." [PMID:13358757, PMID:1433508, VZ:1951]
synonym: "VS" EXACT [VZ:1951]
is_a: GO:0039715 ! nuclear viral factory
created_by: rfoulger
creation_date: 2013-12-19T15:45:32Z

[Term]
id: GO:0039721
name: peristromal region viral factory
namespace: cellular_component
def: "A nuclear viral factory formed at the periphery of the host cell nucleus by Baculoviruses." [PMID:18434402, VZ:1951]
synonym: "PR" RELATED [PMID:18434402, VZ:1951]
is_a: GO:0039715 ! nuclear viral factory
created_by: rfoulger
creation_date: 2013-12-19T15:54:00Z

[Term]
id: GO:0039722
name: suppression by virus of host toll-like receptor signaling pathway
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of toll-like receptor (TLR) signaling in the host organism." [UniProtKB-KW:KW-1225]
synonym: "inhibition of host TLR pathway by virus" EXACT [UniProtKB-KW:KW-1125]
synonym: "suppression by virus of host TLR signaling pathway" EXACT []
is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway
is_a: GO:0039503 ! suppression by virus of host innate immune response
created_by: rfoulger
creation_date: 2014-01-06T11:39:58Z

[Term]
id: GO:0039723
name: suppression by virus of host TBK1 activity
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the activity of the host serine/threonine kinase TBK1." [PR:000001779, UniProtKB-KW:KW-1223]
comment: When TBK1 acts as part of a TBK1-IKBKE-DDX3 complex, consider also annotating to: suppression by virus of host TBK1-IKBKE-DDX3 complex activity ; GO:0039659.
synonym: "inhibition of host TBK1 by virus" EXACT [UniProtKB-KW:KW-1223]
is_a: GO:0039503 ! suppression by virus of host innate immune response
is_a: GO:0039584 ! suppression by virus of host protein kinase activity
created_by: rfoulger
creation_date: 2014-01-06T12:04:44Z

[Term]
id: GO:0039724
name: suppression by virus of host IKBKE activity
namespace: biological_process
def: "Any process in which a virus stops, prevents, or reduces the activity of the host I-kappa-B kinase epsilon (IKBKE/IKK-epsilon/IKK-E)." [PR:000001778, UniProtKB-KW:KW-1224]
comment: When IKBKE acts as part of a TBK1-IKBKE-DDX3 complex, consider also annotating to: suppression by virus of host TBK1-IKBKE-DDX3 complex activity ; GO:0039659.
synonym: "inhibition of host IKBKE by virus" EXACT [UniProtKB-KW:KW-1224]
is_a: GO:0039503 ! suppression by virus of host innate immune response
is_a: GO:0039507 ! suppression by virus of host molecular function
created_by: rfoulger
creation_date: 2014-01-06T12:15:03Z

[Term]
id: GO:0040001
name: establishment of mitotic spindle localization
namespace: biological_process
alt_id: GO:0018986
alt_id: GO:0030605
alt_id: GO:0030606
alt_id: GO:0030608
alt_id: GO:0030610
def: "The cell cycle process in which the directed movement of the mitotic spindle to a specific location in the cell occurs." [GOC:ai]
synonym: "establishment of mitotic spindle localisation" EXACT [GOC:mah]
synonym: "mitotic spindle positioning" EXACT []
synonym: "mitotic spindle positioning and orientation" NARROW []
synonym: "mitotic spindle positioning or orientation" EXACT []
synonym: "spindle positioning during mitosis" RELATED []
synonym: "spindle positioning involved in mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051293 ! establishment of spindle localization
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0051293 ! establishment of spindle localization
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0040002
name: collagen and cuticulin-based cuticle development
namespace: biological_process
def: "Synthesis and deposition of a collagen and cuticulin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Caenorhabditis elegans." [GOC:mtg_sensu]
synonym: "collagen and cuticulin-based cuticle anabolism" EXACT []
synonym: "collagen and cuticulin-based cuticle biosynthetic process" EXACT []
synonym: "collagen and cuticulin-based cuticle formation" EXACT []
synonym: "collagen and cuticulin-based cuticle synthesis" EXACT []
is_a: GO:0042335 ! cuticle development

[Term]
id: GO:0040003
name: chitin-based cuticle development
namespace: biological_process
def: "Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu]
synonym: "chitin-based cuticle anabolism" EXACT []
synonym: "chitin-based cuticle biosynthetic process" EXACT []
synonym: "chitin-based cuticle formation" EXACT []
synonym: "chitin-based cuticle synthesis" EXACT []
is_a: GO:0042335 ! cuticle development

[Term]
id: GO:0040004
name: collagen and cuticulin-based cuticle attachment to epithelium
namespace: biological_process
def: "Attaching of a collagen and cuticulin-based cuticle to the epithelium underlying it. An example of this process is found in Caenorhabditis elegans." [GOC:ems, GOC:mtg_sensu]
synonym: "cuticular attachment to epithelium" BROAD []
is_a: GO:0022404 ! molting cycle process
relationship: part_of GO:0018996 ! molting cycle, collagen and cuticulin-based cuticle

[Term]
id: GO:0040005
name: chitin-based cuticle attachment to epithelium
namespace: biological_process
def: "Attaching of a chitin-containing cuticle to the epithelium underlying it. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
synonym: "cuticular attachment to epithelium" BROAD []
is_a: GO:0022404 ! molting cycle process
relationship: part_of GO:0007591 ! molting cycle, chitin-based cuticle

[Term]
id: GO:0040006
name: obsolete protein-based cuticle attachment to epithelium
namespace: biological_process
def: "OBSOLETE. Attaching of a protein-based cuticle to the epithelium underlying it." [GOC:jl, GOC:mtg_sensu]
comment: This term was made obsolete because 'protein-based cuticle' is an unnecessary grouping term.
synonym: "cuticular attachment to epithelium" BROAD []
synonym: "protein-based cuticle attachment to epithelium" EXACT []
is_obsolete: true
consider: GO:0040004
consider: GO:0040005

[Term]
id: GO:0040007
name: growth
namespace: biological_process
alt_id: GO:0048590
def: "The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma]
comment: See also the biological process term 'cell growth ; GO:0016049'.
subset: goslim_chembl
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "growth pattern" RELATED []
synonym: "non-developmental growth" RELATED [GOC:mah]
is_a: GO:0008150 ! biological_process
disjoint_from: GO:0044848 ! biological phase

[Term]
id: GO:0040008
name: regulation of growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development." [GOC:ems, GOC:mah]
subset: gosubset_prok
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0040007 ! growth
relationship: regulates GO:0040007 ! growth

[Term]
id: GO:0040009
name: regulation of growth rate
namespace: biological_process
def: "Any process that modulates the rate of growth of all or part of an organism." [GOC:mah]
comment: Note that this term and its definition depart from the usual conventions for GO 'regulation' process terms; regulation of rate is not usually distinguished from regulation of extent or frequency, but it makes sense to do so for growth regulation.
is_a: GO:0040008 ! regulation of growth

[Term]
id: GO:0040010
name: positive regulation of growth rate
namespace: biological_process
def: "Any process that increases the rate of growth of all or part of an organism." [GOC:mah]
comment: Note that this term and its definition depart from the usual conventions for GO 'regulation' process terms; regulation of rate is not usually distinguished from regulation of extent or frequency, but it makes sense to do so for growth regulation.
synonym: "activation of growth rate" NARROW []
synonym: "stimulation of growth rate" NARROW []
synonym: "up regulation of growth rate" EXACT []
synonym: "up-regulation of growth rate" EXACT []
synonym: "upregulation of growth rate" EXACT []
is_a: GO:0040009 ! regulation of growth rate
is_a: GO:0045927 ! positive regulation of growth

[Term]
id: GO:0040011
name: locomotion
namespace: biological_process
def: "Self-propelled movement of a cell or organism from one location to another." [GOC:dgh]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0008150 ! biological_process
disjoint_from: GO:0044848 ! biological phase

[Term]
id: GO:0040012
name: regulation of locomotion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of locomotion of a cell or organism." [GOC:ems]
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0040011 ! locomotion
relationship: regulates GO:0040011 ! locomotion

[Term]
id: GO:0040013
name: negative regulation of locomotion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism." [GOC:go_curators]
synonym: "down regulation of locomotion" EXACT []
synonym: "down-regulation of locomotion" EXACT []
synonym: "downregulation of locomotion" EXACT []
synonym: "inhibition of locomotion" NARROW []
is_a: GO:0040012 ! regulation of locomotion
is_a: GO:0048519 ! negative regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0040011 ! locomotion
relationship: negatively_regulates GO:0040011 ! locomotion

[Term]
id: GO:0040014
name: regulation of multicellular organism growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size." [GOC:dph, GOC:ems, GOC:tb]
synonym: "regulation of body growth" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of body size" EXACT [GOC:dph, GOC:tb]
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035264 ! multicellular organism growth
relationship: regulates GO:0035264 ! multicellular organism growth

[Term]
id: GO:0040015
name: negative regulation of multicellular organism growth
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:ems, GOC:tb]
synonym: "negative regulation of body growth" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of body size" EXACT [GOC:dph, GOC:tb]
is_a: GO:0040014 ! regulation of multicellular organism growth
is_a: GO:0048640 ! negative regulation of developmental growth
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035264 ! multicellular organism growth
relationship: negatively_regulates GO:0035264 ! multicellular organism growth

[Term]
id: GO:0040016
name: embryonic cleavage
namespace: biological_process
def: "The first few specialized divisions of an activated animal egg." [GOC:clt, ISBN:0070524300]
is_a: GO:0051301 ! cell division
relationship: part_of GO:0009790 ! embryo development

[Term]
id: GO:0040017
name: positive regulation of locomotion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism." [GOC:go_curators]
synonym: "activation of locomotion" NARROW []
synonym: "stimulation of locomotion" NARROW []
synonym: "up regulation of locomotion" EXACT []
synonym: "up-regulation of locomotion" EXACT []
synonym: "upregulation of locomotion" EXACT []
is_a: GO:0040012 ! regulation of locomotion
is_a: GO:0048518 ! positive regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0040011 ! locomotion
relationship: positively_regulates GO:0040011 ! locomotion

[Term]
id: GO:0040018
name: positive regulation of multicellular organism growth
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "positive regulation of body growth" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of body size" EXACT [GOC:dph, GOC:tb]
is_a: GO:0040014 ! regulation of multicellular organism growth
is_a: GO:0048639 ! positive regulation of developmental growth
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035264 ! multicellular organism growth
relationship: positively_regulates GO:0035264 ! multicellular organism growth

[Term]
id: GO:0040019
name: positive regulation of embryonic development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of embryonic development." [GOC:go_curators]
synonym: "activation of embryonic development" NARROW []
synonym: "stimulation of embryonic development" NARROW []
synonym: "up regulation of embryonic development" EXACT []
synonym: "up-regulation of embryonic development" EXACT []
synonym: "upregulation of embryonic development" EXACT []
is_a: GO:0045995 ! regulation of embryonic development
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009790 ! embryo development
relationship: positively_regulates GO:0009790 ! embryo development

[Term]
id: GO:0040020
name: regulation of meiotic nuclear division
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of meiosis, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes." [GOC:ems, GOC:ma]
synonym: "regulation of meiosis" BROAD [GOC:vw]
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0051445 ! regulation of meiotic cell cycle
is_a: GO:0051783 ! regulation of nuclear division
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007126 ! meiotic nuclear division
relationship: regulates GO:0007126 ! meiotic nuclear division

[Term]
id: GO:0040021
name: hermaphrodite germ-line sex determination
namespace: biological_process
alt_id: GO:0042005
def: "The determination of sex and sexual phenotype in the germ line of a hermaphrodite." [GOC:ems]
is_a: GO:0018992 ! germ-line sex determination

[Term]
id: GO:0040022
name: feminization of hermaphroditic germ-line
namespace: biological_process
def: "The determination of female sex and sexual phenotype in the germ-line of the hermaphrodite." [GOC:ems]
is_a: GO:0040021 ! hermaphrodite germ-line sex determination

[Term]
id: GO:0040023
name: establishment of nucleus localization
namespace: biological_process
def: "The directed movement of the nucleus to a specific location within a cell." [GOC:ai]
subset: goslim_aspergillus
synonym: "establishment of cell nucleus localization" EXACT []
synonym: "establishment of localization of nucleus" EXACT []
synonym: "establishment of nucleus localisation" EXACT [GOC:mah]
synonym: "establishment of position of nucleus" EXACT []
synonym: "nuclear positioning" EXACT []
synonym: "nucleus positioning" EXACT []
synonym: "positioning of nucleus" EXACT []
is_a: GO:0051647 ! nucleus localization
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0051656 ! establishment of organelle localization

[Term]
id: GO:0040024
name: dauer larval development
namespace: biological_process
def: "The process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding." [GOC:ems, ISBN:087969307X]
is_a: GO:0002119 ! nematode larval development

[Term]
id: GO:0040025
name: vulval development
namespace: biological_process
def: "The process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult." [GOC:ems, GOC:kmv, ISBN:087969307X]
is_a: GO:0048569 ! post-embryonic organ development
relationship: part_of GO:0002119 ! nematode larval development

[Term]
id: GO:0040026
name: positive regulation of vulval development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult." [GOC:ems, GOC:kmv]
synonym: "activation of vulval development" RELATED []
synonym: "stimulation of vulval development" RELATED []
synonym: "up regulation of vulval development" RELATED []
synonym: "up-regulation of vulval development" RELATED []
synonym: "upregulation of vulval development" RELATED []
is_a: GO:0040028 ! regulation of vulval development
is_a: GO:0061063 ! positive regulation of nematode larval development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0040025 ! vulval development
relationship: positively_regulates GO:0040025 ! vulval development

[Term]
id: GO:0040027
name: negative regulation of vulval development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult." [GOC:ems, GOC:kmv]
synonym: "down regulation of vulval development" EXACT []
synonym: "down-regulation of vulval development" EXACT []
synonym: "downregulation of vulval development" EXACT []
synonym: "inhibition of vulval development" NARROW []
is_a: GO:0040028 ! regulation of vulval development
is_a: GO:0061064 ! negative regulation of nematode larval development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0040025 ! vulval development
relationship: negatively_regulates GO:0040025 ! vulval development

[Term]
id: GO:0040028
name: regulation of vulval development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult." [GOC:kmv, GOC:ma]
is_a: GO:0061062 ! regulation of nematode larval development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0040025 ! vulval development
relationship: regulates GO:0040025 ! vulval development

[Term]
id: GO:0040029
name: regulation of gene expression, epigenetic
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gene expression; the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence." [PMID:10521337, PMID:11498582]
subset: goslim_plant
subset: gosubset_prok
is_a: GO:0010468 ! regulation of gene expression

[Term]
id: GO:0040030
name: regulation of molecular function, epigenetic
namespace: biological_process
def: "Any heritable epigenetic process that modulates the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich ('prion') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya." [GOC:dph, GOC:ems, GOC:tb, PMID:10611975, PMID:11050225, PMID:11447696, PMID:11685242, PMID:11782551]
synonym: "regulation of protein activity, epigenetic" EXACT [GOC:dph, GOC:tb]
is_a: GO:0065009 ! regulation of molecular function

[Term]
id: GO:0040031
name: snRNA modification
namespace: biological_process
def: "The covalent alteration of one or more nucleotides within snRNA, resulting in a change in the properties of the snRNA." [GOC:jl]
is_a: GO:0009451 ! RNA modification
is_a: GO:0016073 ! snRNA metabolic process

[Term]
id: GO:0040032
name: post-embryonic body morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the post-embryonic soma are generated and organized." [GOC:ems, ISBN:0140512888]
comment: Note that this term was 'body morphogenesis (sensu Nematoda)'.
is_a: GO:0009886 ! post-embryonic morphogenesis
is_a: GO:0010171 ! body morphogenesis

[Term]
id: GO:0040033
name: negative regulation of translation, ncRNA-mediated
namespace: biological_process
def: "Any process, mediated by small non-coding RNAs, that stops, prevents or reduces the rate that mRNAs are effectively translated into protein." [GOC:dph, GOC:ems, GOC:tb]
synonym: "down regulation of mRNA translation, ncRNA-mediated" EXACT []
synonym: "down-regulation of mRNA translation, ncRNA-mediated" EXACT []
synonym: "downregulation of mRNA translation, ncRNA-mediated" EXACT []
synonym: "inhibition of mRNA translation, ncRNA-mediated" NARROW []
is_a: GO:0017148 ! negative regulation of translation
is_a: GO:0045974 ! regulation of translation, ncRNA-mediated
relationship: negatively_regulates GO:0006412 ! translation

[Term]
id: GO:0040034
name: regulation of development, heterochronic
namespace: biological_process
def: "Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and the rate at which this time point is reached." [PMID:9442909]
synonym: "developmental timing" RELATED []
synonym: "heterochronic regulation of development" EXACT []
synonym: "temporal regulation of development" EXACT []
is_a: GO:0050793 ! regulation of developmental process

[Term]
id: GO:0040035
name: hermaphrodite genitalia development
namespace: biological_process
def: "The process whose specific outcome is the progression of the hermaphrodite genitalia over time, from formation to the mature structures." [GOC:ems, ISBN:0140512888]
is_a: GO:0008406 ! gonad development
is_a: GO:0048806 ! genitalia development

[Term]
id: GO:0040036
name: regulation of fibroblast growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity." [GOC:go_curators]
synonym: "regulation of FGF receptor signaling pathway" EXACT []
synonym: "regulation of FGF receptor signalling pathway" EXACT []
synonym: "regulation of FGFR signaling pathway" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0090287 ! regulation of cellular response to growth factor stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008543 ! fibroblast growth factor receptor signaling pathway
relationship: regulates GO:0008543 ! fibroblast growth factor receptor signaling pathway

[Term]
id: GO:0040037
name: negative regulation of fibroblast growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity." [GOC:go_curators]
synonym: "down regulation of fibroblast growth factor receptor signaling pathway" EXACT []
synonym: "down-regulation of fibroblast growth factor receptor signaling pathway" EXACT []
synonym: "downregulation of fibroblast growth factor receptor signaling pathway" EXACT []
synonym: "inhibition of fibroblast growth factor receptor signaling pathway" NARROW []
synonym: "negative regulation of FGF receptor signaling pathway" EXACT []
synonym: "negative regulation of FGF receptor signalling pathway" EXACT []
synonym: "negative regulation of FGFR signaling pathway" EXACT []
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0040036 ! regulation of fibroblast growth factor receptor signaling pathway
is_a: GO:0090288 ! negative regulation of cellular response to growth factor stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008543 ! fibroblast growth factor receptor signaling pathway
relationship: negatively_regulates GO:0008543 ! fibroblast growth factor receptor signaling pathway

[Term]
id: GO:0040038
name: polar body extrusion after meiotic divisions
namespace: biological_process
def: "The cell cycle process in which two small cells are generated, as byproducts destined to degenerate, as a result of the first and second meiotic divisions of a primary oocyte during its development to a mature ovum. One polar body is formed in the first division of meiosis and the other in the second division; at each division, the cytoplasm divides unequally, so that the polar body is of much smaller size than the developing oocyte. At the second division in which a polar body is formed, the polar body and the developing oocyte each contain a haploid set of chromosomes." [GOC:ems, ISBN:0198506732]
is_a: GO:0033206 ! meiotic cytokinesis
relationship: part_of GO:0007143 ! female meiotic division

[Term]
id: GO:0040039
name: inductive cell migration
namespace: biological_process
def: "Migration of a cell in a multicellular organism that, having changed its location, is required to induce normal properties in one or more cells at its new location. An example of this would be the distal tip cells of Caenorhabditis elegans." [ISBN:087969307X, ISBN:0879694882]
is_a: GO:0016477 ! cell migration

[Term]
id: GO:0040040
name: thermosensory behavior
namespace: biological_process
def: "Behavior that is dependent upon the sensation of temperature." [GOC:ems]
synonym: "behavioral response to temperature stimulus" EXACT []
synonym: "behavioural response to temperature stimulus" EXACT []
synonym: "thermosensory behaviour" EXACT []
is_a: GO:0009266 ! response to temperature stimulus
is_a: GO:0044708 ! single-organism behavior

[Term]
id: GO:0042000
name: translocation of peptides or proteins into host
namespace: biological_process
def: "The directed movement of peptides or proteins produced by an organism to a location inside its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
synonym: "transport of peptides or proteins into host" EXACT []
is_a: GO:0044417 ! translocation of molecules into host
is_a: GO:0051808 ! translocation of peptides or proteins into other organism involved in symbiotic interaction

[Term]
id: GO:0042001
name: hermaphrodite somatic sex determination
namespace: biological_process
alt_id: GO:0042002
def: "The determination of sex and sexual phenotypes in a hermaphroditic organism's soma. An example of this is found in Caenorhabditis elegans." [GOC:ems]
is_a: GO:0018993 ! somatic sex determination

[Term]
id: GO:0042003
name: masculinization of hermaphrodite soma
namespace: biological_process
def: "Promotion of male sex and sexual phenotypes in the hermaphroditic nematode soma. An example of this is found in Caenorhabditis elegans." [GOC:ems]
is_a: GO:0042001 ! hermaphrodite somatic sex determination

[Term]
id: GO:0042004
name: feminization of hermaphrodite soma
namespace: biological_process
def: "Promotion of female sex and sexual phenotypes in the hermaphroditic soma. An example of this is found in Caenorhabditis elegans." [GOC:ems]
is_a: GO:0042001 ! hermaphrodite somatic sex determination

[Term]
id: GO:0042006
name: masculinization of hermaphroditic germ-line
namespace: biological_process
def: "The determination of male sex and sexual phenotype in the germ-line of the hermaphrodite. An example of this is found in Caenorhabditis elegans." [GOC:ems]
is_a: GO:0040021 ! hermaphrodite germ-line sex determination

[Term]
id: GO:0042007
name: interleukin-18 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-18." [GOC:jl]
synonym: "IL-18 binding" EXACT []
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0042008
name: interleukin-18 receptor activity
namespace: molecular_function
def: "Combining with interleukin-18 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
synonym: "IL-18 receptor activity" EXACT [GOC:mah]
synonym: "IL-18R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity
relationship: has_part GO:0042007 ! interleukin-18 binding
relationship: part_of GO:0035655 ! interleukin-18-mediated signaling pathway

[Term]
id: GO:0042009
name: interleukin-15 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-15." [GOC:jl]
synonym: "IL-15 binding" EXACT []
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0042010
name: interleukin-15 receptor activity
namespace: molecular_function
def: "Combining with interleukin-15 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
synonym: "IL-15 receptor activity" EXACT [GOC:mah]
synonym: "IL-15R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity
relationship: has_part GO:0042009 ! interleukin-15 binding
relationship: part_of GO:0035723 ! interleukin-15-mediated signaling pathway

[Term]
id: GO:0042011
name: interleukin-16 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-16." [GOC:jl]
synonym: "IL-16 binding" EXACT []
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0042012
name: interleukin-16 receptor activity
namespace: molecular_function
def: "Combining with interleukin-16 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
synonym: "IL-16 receptor activity" EXACT [GOC:mah]
synonym: "IL-16R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity
relationship: has_part GO:0042011 ! interleukin-16 binding

[Term]
id: GO:0042013
name: interleukin-19 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-19." [GOC:jl]
synonym: "IL-19 binding" EXACT []
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0042014
name: interleukin-19 receptor activity
namespace: molecular_function
def: "Combining with interleukin-19 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
synonym: "IL-19 receptor activity" EXACT [GOC:mah]
synonym: "IL-19R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity
relationship: has_part GO:0042013 ! interleukin-19 binding

[Term]
id: GO:0042015
name: interleukin-20 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-20." [GOC:jl]
synonym: "IL-20 binding" EXACT []
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0042016
name: interleukin-20 receptor activity
namespace: molecular_function
def: "Combining with interleukin-20 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
synonym: "IL-20 receptor activity" EXACT [GOC:mah]
synonym: "IL-20R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity
relationship: has_part GO:0042015 ! interleukin-20 binding

[Term]
id: GO:0042017
name: interleukin-22 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-22." [GOC:jl]
synonym: "IL-22 binding" EXACT []
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0042018
name: interleukin-22 receptor activity
namespace: molecular_function
def: "Combining with interleukin-22 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
synonym: "IL-22 receptor activity" EXACT [GOC:mah]
synonym: "IL-22R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity
relationship: has_part GO:0042017 ! interleukin-22 binding

[Term]
id: GO:0042019
name: interleukin-23 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-23." [GOC:jl]
synonym: "IL-23 binding" EXACT []
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0042020
name: interleukin-23 receptor activity
namespace: molecular_function
def: "Combining with interleukin-23 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
synonym: "IL-23 receptor activity" EXACT [GOC:mah]
synonym: "IL-23R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity
relationship: has_part GO:0042019 ! interleukin-23 binding
relationship: part_of GO:0038155 ! interleukin-23-mediated signaling pathway

[Term]
id: GO:0042021
name: granulocyte macrophage colony-stimulating factor complex binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the granulocyte macrophage colony-stimulating factor complex." [GOC:ai]
synonym: "GM-CSF complex binding" EXACT []
synonym: "GMC-SF complex binding" EXACT []
synonym: "granulocyte macrophage colony stimulating factor complex binding" EXACT []
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0042022
name: interleukin-12 receptor complex
namespace: cellular_component
def: "A protein complex that binds interleukin-12; comprises a beta1 and a beta2 subunit." [GOC:ebc, GOC:mah, PMID:10971505]
synonym: "IL-12 receptor complex" EXACT [GOC:add]
synonym: "IL12RB1-IL12RB2 complex" NARROW [CORUM:2026]
is_a: GO:0098802 ! plasma membrane receptor complex
relationship: part_of GO:0005887 ! integral component of plasma membrane

[Term]
id: GO:0042023
name: DNA endoreduplication
namespace: biological_process
def: "Regulated re-replication of DNA within a single cell cycle, resulting in an increased cell ploidy. An example of this process occurs in the synthesis of Drosophila salivary gland cell polytene chromosomes." [GOC:jl, GOC:vw]
comment: Note that this term is only to be used in situations were this process occurs normally. Not to be used to describe mutant or diseased states.
subset: gosubset_prok
synonym: "DNA endoreplication" EXACT []
synonym: "DNA re-duplication" EXACT []
is_a: GO:0044786 ! cell cycle DNA replication
relationship: has_part GO:0006270 ! DNA replication initiation

[Term]
id: GO:0042025
name: host cell nucleus
namespace: cellular_component
alt_id: GO:0033649
def: "A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
subset: gosubset_prok
is_a: GO:0033648 ! host intracellular membrane-bounded organelle

[Term]
id: GO:0042026
name: protein refolding
namespace: biological_process
def: "The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones." [GOC:mb]
subset: gosubset_prok
synonym: "heat shock protein activity" RELATED []
is_a: GO:0006457 ! protein folding

[Term]
id: GO:0042027
name: obsolete cyclophilin-type peptidyl-prolyl cis-trans isomerase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: peptidylproline (omega=180) = peptidylproline (omega=0)." [EC:5.2.1.8]
comment: This term was made obsolete because it is contains gene product specific characteristics.
synonym: "cyclophilin-type peptidyl-prolyl cis-trans isomerase activity" EXACT []
is_obsolete: true
consider: GO:0003755

[Term]
id: GO:0042029
name: obsolete fibrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of 14-Ala-Leu-15 in insulin B chain and cleavage of 413-Lys-Leu-414 in alpha chain of fibrinogen." [EC:3.4.24.72, PMID:7725320]
comment: This term was made obsolete because it represents a gene product.
synonym: "Agkistrodon contortrix contortrix metalloproteinase activity" NARROW [EC:3.4.24.72]
synonym: "Agkistrodon contortrix contortrix venom metalloproteinase activity" NARROW [EC:3.4.24.72]
synonym: "fibrinolytic proteinase activity" EXACT [EC:3.4.24.72]
synonym: "fibrolase activity" EXACT []
xref: EC:3.4.24.72
xref: MetaCyc:3.4.24.72-RXN
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0042030
name: ATPase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of ATP to ADP and orthophosphate." [GOC:jl]
synonym: "adenosinetriphosphatase inhibitor" EXACT []
is_a: GO:0004857 ! enzyme inhibitor activity
is_a: GO:0060590 ! ATPase regulator activity
relationship: negatively_regulates GO:0016887 ! ATPase activity

[Term]
id: GO:0042031
name: obsolete angiotensin-converting enzyme inhibitor activity
namespace: molecular_function
def: "OBSOLETE. Stops, prevents or reduces the activity of angiotensin-converting enzyme, thereby preventing the synthesis of angiotensin II from its precursor, angiotensin I." [GOC:jl]
comment: This term was made obsolete because it represents a regulator of a non-existent molecular function term.
synonym: "ACE inhibitor" EXACT []
synonym: "angiotensin-converting enzyme inhibitor activity" EXACT []
synonym: "peptidyl dipeptidase A inhibitor" EXACT []
xref: Wikipedia:ACE_inhibitor
is_obsolete: true
replaced_by: GO:0060422

[Term]
id: GO:0042033
name: chemokine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of chemokines, any member of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria." [GOC:BHF, GOC:rl, http://en.wikipedia.org/wiki/Chemokine, ISBN:0198506732, PMID:12183377]
synonym: "chemokine anabolism" EXACT []
synonym: "chemokine biosynthesis" EXACT []
synonym: "chemokine formation" EXACT []
synonym: "chemokine synthesis" EXACT []
is_a: GO:0042089 ! cytokine biosynthetic process
is_a: GO:0050755 ! chemokine metabolic process
relationship: part_of GO:0032602 ! chemokine production

[Term]
id: GO:0042034
name: peptidyl-L-lysine methyl ester biosynthetic process from peptidyl-lysine
namespace: biological_process
def: "The modification of a C-terminal peptidyl-lysine to form peptidyl-L-lysine methyl ester." [RESID:AA0318]
synonym: "peptidyl-lysine esterification" EXACT []
xref: RESID:AA0318
is_a: GO:0006481 ! C-terminal protein methylation
is_a: GO:0018205 ! peptidyl-lysine modification
is_a: GO:0018350 ! protein esterification

[Term]
id: GO:0042035
name: regulation of cytokine biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines." [GOC:go_curators]
synonym: "regulation of cytokine anabolism" EXACT []
synonym: "regulation of cytokine biosynthesis" EXACT []
synonym: "regulation of cytokine formation" EXACT []
synonym: "regulation of cytokine synthesis" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0051246 ! regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042089 ! cytokine biosynthetic process
relationship: regulates GO:0042089 ! cytokine biosynthetic process

[Term]
id: GO:0042036
name: negative regulation of cytokine biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines." [GOC:go_curators]
synonym: "down regulation of cytokine biosynthetic process" EXACT []
synonym: "down-regulation of cytokine biosynthetic process" EXACT []
synonym: "downregulation of cytokine biosynthetic process" EXACT []
synonym: "inhibition of cytokine biosynthetic process" NARROW []
synonym: "negative regulation of cytokine anabolism" EXACT []
synonym: "negative regulation of cytokine biosynthesis" EXACT []
synonym: "negative regulation of cytokine formation" EXACT []
synonym: "negative regulation of cytokine synthesis" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
is_a: GO:0051248 ! negative regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042089 ! cytokine biosynthetic process
relationship: negatively_regulates GO:0042089 ! cytokine biosynthetic process

[Term]
id: GO:0042037
name: peptidyl-histidine methylation, to form pros-methylhistidine
namespace: biological_process
alt_id: GO:0042260
def: "The methylation of peptidyl-L-histidine to form peptidyl-L-3'-methyl-L-histidine (otherwise known as pi-methylhistidine, pros-methylhistidine)." [RESID:AA0073]
subset: gosubset_prok
synonym: "peptidyl-histidine pros-methylation" EXACT []
xref: RESID:AA0073
is_a: GO:0018021 ! peptidyl-histidine methylation

[Term]
id: GO:0042038
name: peptidyl-histidine methylation, to form tele-methylhistidine
namespace: biological_process
alt_id: GO:0042261
def: "The methylation of peptidyl-L-histidine to form peptidyl-L-1'-methyl-L-histidine (otherwise known as tau-methylhistidine, tele-methylhistidine)." [RESID:AA0317]
subset: gosubset_prok
synonym: "peptidyl-histidine tele-methylation" EXACT []
xref: RESID:AA0317
is_a: GO:0018021 ! peptidyl-histidine methylation

[Term]
id: GO:0042039
name: vanadium incorporation into metallo-sulfur cluster
namespace: biological_process
def: "The incorporation of vanadium a metallo-sulfur cluster such as VFe(7-8)S(n)." [PMID:11053414]
subset: gosubset_prok
synonym: "vanadium incorporation into metallo-sulphur cluster" EXACT []
is_a: GO:0018282 ! metal incorporation into metallo-sulfur cluster

[Term]
id: GO:0042040
name: metal incorporation into metallo-molybdopterin complex
namespace: biological_process
def: "The incorporation of a metal into a metallo-molybdopterin complex." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006464 ! cellular protein modification process

[Term]
id: GO:0042042
name: tungsten incorporation into tungsten-molybdopterin complex
namespace: biological_process
def: "The incorporation of tungsten into a tungsten-molybdopterin complex." [GOC:ai]
subset: gosubset_prok
is_a: GO:0042040 ! metal incorporation into metallo-molybdopterin complex

[Term]
id: GO:0042043
name: neurexin family protein binding
namespace: molecular_function
alt_id: GO:0019963
def: "Interacting selectively and non-covalently with neurexins, synaptic cell surface proteins related to latrotoxin receptor, laminin and agrin. Neurexins act as cell recognition molecules at nerve terminals." [GOC:curators, GOC:pr, PMID:18923512]
synonym: "neuroligin" RELATED []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0042044
name: fluid transport
namespace: biological_process
def: "The directed movement of substances that are in liquid form in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0044765 ! single-organism transport

[Term]
id: GO:0042045
name: epithelial fluid transport
namespace: biological_process
def: "The directed movement of fluid across epithelia." [GOC:jl, PMID:11390830]
is_a: GO:0042044 ! fluid transport
is_a: GO:0055085 ! transmembrane transport

[Term]
id: GO:0042046
name: W-molybdopterin cofactor metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the W-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear tungsten ion (W) coordinated by one or two molybdopterin ligands." [ISSN:09498257]
subset: gosubset_prok
synonym: "Moco metabolic process" BROAD []
synonym: "Moco metabolism" BROAD []
synonym: "W-molybdopterin cofactor metabolism" EXACT []
is_a: GO:0043545 ! molybdopterin cofactor metabolic process

[Term]
id: GO:0042047
name: W-molybdopterin cofactor biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the W-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear tungsten ion (W) coordinated by one or two molybdopterin ligands." [ISSN:09498257]
subset: gosubset_prok
synonym: "Moco biosynthesis" BROAD []
synonym: "Moco biosynthetic process" BROAD []
synonym: "W-molybdopterin cofactor anabolism" EXACT []
synonym: "W-molybdopterin cofactor biosynthesis" EXACT []
synonym: "W-molybdopterin cofactor formation" EXACT []
synonym: "W-molybdopterin cofactor synthesis" EXACT []
is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0019538 ! protein metabolic process
is_a: GO:0032324 ! molybdopterin cofactor biosynthetic process
is_a: GO:0042046 ! W-molybdopterin cofactor metabolic process
relationship: has_part GO:0042042 ! tungsten incorporation into tungsten-molybdopterin complex

[Term]
id: GO:0042048
name: olfactory behavior
namespace: biological_process
def: "The behavior of an organism in response to an odor." [GOC:jid, GOC:pr]
synonym: "behavioral response to scent" EXACT []
synonym: "behavioral response to smell" EXACT []
synonym: "behavioural response to odour" EXACT []
synonym: "behavioural response to scent" EXACT []
synonym: "behavioural response to smell" EXACT []
synonym: "olfactory behaviour" EXACT []
is_a: GO:0007635 ! chemosensory behavior

[Term]
id: GO:0042049
name: cellular acyl-CoA homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of acyl-CoA within a cell or between a cell and its external environment." [GOC:ai, GOC:dph, GOC:tb]
subset: gosubset_prok
synonym: "cell acyl-CoA homeostasis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0030002 ! cellular anion homeostasis

[Term]
id: GO:0042051
name: compound eye photoreceptor development
namespace: biological_process
def: "The process whose specific outcome is the progression of a light-responsive receptor in the compound eye over time, from its formation to the mature structure." [GOC:bf]
synonym: "adult eye photoreceptor development" NARROW []
is_a: GO:0042462 ! eye photoreceptor cell development
relationship: part_of GO:0001751 ! compound eye photoreceptor cell differentiation

[Term]
id: GO:0042052
name: rhabdomere development
namespace: biological_process
def: "The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883]
synonym: "rhabdomere organization" EXACT [GOC:mah]
is_a: GO:0006996 ! organelle organization
relationship: part_of GO:0042051 ! compound eye photoreceptor development

[Term]
id: GO:0042053
name: regulation of dopamine metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving dopamine." [GOC:go_curators]
synonym: "regulation of dopamine metabolism" EXACT []
is_a: GO:0042069 ! regulation of catecholamine metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042417 ! dopamine metabolic process
relationship: regulates GO:0042417 ! dopamine metabolic process

[Term]
id: GO:0042054
name: histone methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or lysine residue." [EC:2.1.1.43]
synonym: "histone methylase activity" EXACT [GOC:mah]
is_a: GO:0008276 ! protein methyltransferase activity
relationship: part_of GO:0016571 ! histone methylation

[Term]
id: GO:0042056
name: chemoattractant activity
namespace: molecular_function
def: "Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal." [GOC:go_curators, ISBN:0198506732]
subset: goslim_chembl
subset: goslim_pir
subset: gosubset_prok
synonym: "attractant" BROAD []
is_a: GO:0003674 ! molecular_function
relationship: part_of GO:0050918 ! positive chemotaxis

[Term]
id: GO:0042057
name: obsolete transforming growth factor beta receptor anchoring activity
namespace: molecular_function
def: "OBSOLETE. Binds to transforming growth factor beta receptor and anchors it to a particular subcellular location." [GOC:ai]
comment: This term was made obsolete because it represents a combination of process and function information.
synonym: "TGF-beta receptor anchoring activity" EXACT []
synonym: "TGFbeta receptor anchoring activity" EXACT []
synonym: "transforming growth factor beta receptor anchor activity" EXACT []
synonym: "transforming growth factor beta receptor anchoring activity" EXACT []
is_obsolete: true
consider: GO:0005160
consider: GO:0008104

[Term]
id: GO:0042058
name: regulation of epidermal growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators]
synonym: "regulation of EGF receptor signaling pathway" EXACT []
synonym: "regulation of EGF receptor signalling pathway" EXACT []
synonym: "regulation of EGFR signaling pathway" EXACT []
is_a: GO:1901184 ! regulation of ERBB signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007173 ! epidermal growth factor receptor signaling pathway
relationship: regulates GO:0007173 ! epidermal growth factor receptor signaling pathway

[Term]
id: GO:0042059
name: negative regulation of epidermal growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators]
synonym: "down regulation of epidermal growth factor receptor signaling pathway" EXACT []
synonym: "down-regulation of epidermal growth factor receptor signaling pathway" EXACT []
synonym: "downregulation of epidermal growth factor receptor signaling pathway" EXACT []
synonym: "inhibition of epidermal growth factor receptor signaling pathway" NARROW []
synonym: "negative regulation of EGF receptor signaling pathway" EXACT []
synonym: "negative regulation of EGF receptor signalling pathway" EXACT []
synonym: "negative regulation of EGFR signaling pathway" EXACT []
xref: Reactome:REACT_105346 "EGFR downregulation, Rattus norvegicus"
xref: Reactome:REACT_12484 "EGFR downregulation, Homo sapiens"
xref: Reactome:REACT_29383 "EGFR downregulation, Caenorhabditis elegans"
xref: Reactome:REACT_29983 "EGFR downregulation, Danio rerio"
xref: Reactome:REACT_61525 "EGFR downregulation, Canis familiaris"
xref: Reactome:REACT_77404 "EGFR downregulation, Xenopus tropicalis"
xref: Reactome:REACT_79301 "EGFR downregulation, Taeniopygia guttata"
xref: Reactome:REACT_84998 "EGFR downregulation, Mus musculus"
xref: Reactome:REACT_85833 "EGFR downregulation, Sus scrofa"
xref: Reactome:REACT_87942 "EGFR downregulation, Gallus gallus"
xref: Reactome:REACT_89584 "EGFR downregulation, Bos taurus"
xref: Reactome:REACT_98920 "EGFR downregulation, Drosophila melanogaster"
is_a: GO:0042058 ! regulation of epidermal growth factor receptor signaling pathway
is_a: GO:1901185 ! negative regulation of ERBB signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007173 ! epidermal growth factor receptor signaling pathway
relationship: negatively_regulates GO:0007173 ! epidermal growth factor receptor signaling pathway

[Term]
id: GO:0042060
name: wound healing
namespace: biological_process
def: "The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788]
xref: Wikipedia:Wound_healing
is_a: GO:0009611 ! response to wounding

[Term]
id: GO:0042062
name: long-term strengthening of neuromuscular junction
namespace: biological_process
def: "Any process that results in an increase in the efficacy of transmission at a neuromuscular synapse." [GO_REF:0000021, GOC:mtg_15jun06_goc\:pd]
comment: This term was added by GO_REF:0000021.
is_a: GO:0050806 ! positive regulation of synaptic transmission
relationship: part_of GO:0008582 ! regulation of synaptic growth at neuromuscular junction

[Term]
id: GO:0042063
name: gliogenesis
namespace: biological_process
def: "The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia." [GOC:dgh, GOC:jid]
synonym: "glial cell generation" EXACT systematic_synonym []
is_a: GO:0022008 ! neurogenesis

[Term]
id: GO:0042064
name: obsolete cell adhesion receptor regulator activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "cell adhesion receptor regulator activity" EXACT []
is_obsolete: true
consider: GO:0005102
consider: GO:0030155

[Term]
id: GO:0042065
name: glial cell growth
namespace: biological_process
def: "Growth of glial cells, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:dph, GOC:isa_complete, GOC:jid]
is_a: GO:0048588 ! developmental cell growth
relationship: part_of GO:0042063 ! gliogenesis

[Term]
id: GO:0042066
name: perineurial glial growth
namespace: biological_process
def: "Glial cell growth that occurs in the perineurium, a cell layer that ensheaths projections of peripheral nerves, such as motor axons." [GOC:mah, PMID:11517334, PMID:18176560]
is_a: GO:0042065 ! glial cell growth

[Term]
id: GO:0042067
name: establishment of ommatidial planar polarity
namespace: biological_process
def: "The specification of polarized ommatidia. Ommatidia occur in two chiral forms. The trapezoidal arrangement of photoreceptors in the dorsal part of the eye is the mirror image of that in the ventral part." [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:3076112, PMID:3937883]
synonym: "establishment of ommatidial polarity" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0001736 ! establishment of planar polarity
is_a: GO:0007163 ! establishment or maintenance of cell polarity
relationship: part_of GO:0001745 ! compound eye morphogenesis

[Term]
id: GO:0042068
name: regulation of pteridine metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving pteridine." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of pteridine metabolism" EXACT []
is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019889 ! pteridine metabolic process
relationship: regulates GO:0019889 ! pteridine metabolic process

[Term]
id: GO:0042069
name: regulation of catecholamine metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catecholamines." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of catecholamine metabolism" EXACT []
is_a: GO:0033238 ! regulation of cellular amine metabolic process
is_a: GO:0080090 ! regulation of primary metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006584 ! catecholamine metabolic process
relationship: regulates GO:0006584 ! catecholamine metabolic process

[Term]
id: GO:0042070
name: maintenance of oocyte nucleus location involved in oocyte dorsal/ventral axis specification
namespace: biological_process
alt_id: GO:0048127
def: "Maintenance of the oocyte nucleus in a particular position within the cell during the establishment and maintenance of the axes of the oocyte. An example of this process is found In Drosophila melanogaster." [GOC:dph, GOC:mah, GOC:mtg_sensu, GOC:tb]
synonym: "maintenance of oocyte nucleus localization during oocyte axis determination" BROAD [GOC:dph, GOC:tb]
synonym: "maintenance of oocyte nucleus location involved in oocyte dorsal-ventral axis specification" EXACT [GOC:mah]
synonym: "maintenance of oocyte nucleus location involved in oocyte dorsal/ventral axis determination" EXACT [GOC:dph, GOC:tb]
synonym: "maintenance of oocyte nucleus location involved in oocyte dorsoventral axis specification" EXACT [GOC:mah]
synonym: "maintenance of oocyte nucleus position during oocyte axis determination" BROAD []
synonym: "oocyte axis determination, maintenance of oocyte nucleus localization" BROAD []
synonym: "oocyte axis determination, maintenance of oocyte nucleus position" BROAD []
synonym: "oocyte axis determination, oocyte nucleus anchoring" BROAD []
synonym: "oocyte nucleus anchoring during oocyte axis determination" BROAD []
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0051658 ! maintenance of nucleus location
relationship: part_of GO:0051663 ! oocyte nucleus localization involved in oocyte dorsal/ventral axis specification

[Term]
id: GO:0042071
name: leucokinin receptor activity
namespace: molecular_function
def: "Combining with a leucokinin, any of several octapeptide hormones found in insects, and transmitting the signal to initiate a change in cell activity." [GOC:mah, GOC:signaling, PMID:2716741]
is_a: GO:0038023 ! signaling receptor activity
relationship: part_of GO:0009755 ! hormone-mediated signaling pathway

[Term]
id: GO:0042072
name: obsolete cell adhesion receptor inhibitor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "cell adhesion receptor inhibitor activity" EXACT []
is_obsolete: true
consider: GO:0005102
consider: GO:0007162

[Term]
id: GO:0042073
name: intraciliary transport
namespace: biological_process
alt_id: GO:0035734
def: "The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins." [GOC:cilia, GOC:kmv, PMID:17981739, PMID:18180368, PMID:22869374]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.
synonym: "intraflagellar transport" EXACT []
synonym: "intraflagellar transport involved in cilium organization" EXACT []
synonym: "intraflagellar transport involved in microtubule-based flagellum organisation" EXACT []
xref: Wikipedia:Intraflagellar_transport
is_a: GO:0031503 ! protein complex localization
is_a: GO:0098840 ! protein transport along microtubule
relationship: occurs_in GO:0005929 ! cilium
relationship: part_of GO:0044782 ! cilium organization

[Term]
id: GO:0042074
name: cell migration involved in gastrulation
namespace: biological_process
def: "The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression)." [GOC:jl, http://www.cellmigration.org/, ISBN:0878932437]
is_a: GO:0001667 ! ameboidal-type cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: part_of GO:0007369 ! gastrulation
relationship: part_of GO:0007369 ! gastrulation

[Term]
id: GO:0042075
name: nickel incorporation into nickel-iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide
namespace: biological_process
def: "The incorporation of nickel into a nickel-iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide, found in carbon monoxide dehydrogenase." [RESID:AA0310]
subset: gosubset_prok
synonym: "nickel incorporation into nickel-iron-sulphur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulphide" EXACT []
xref: RESID:AA0310
is_a: GO:0016226 ! iron-sulfur cluster assembly
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018202 ! peptidyl-histidine modification
is_a: GO:0018414 ! nickel incorporation into metallo-sulfur cluster
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0042076
name: protein phosphate-linked glycosylation
namespace: biological_process
def: "The glycosylation of peptidyl-amino acids through a phosphoester bond forming, for example, GlcNAc-alpha-1-P-Ser residues." [PMID:7499424]
subset: gosubset_prok
synonym: "phosphoglycosylation" EXACT []
synonym: "protein amino acid phosphate-linked glycosylation" EXACT [GOC:bf]
is_a: GO:0006486 ! protein glycosylation

[Term]
id: GO:0042077
name: protein phosphate-linked glycosylation via serine
namespace: biological_process
def: "The glycosylation of peptidyl-serine through a phosphoester bond forming, for example, GlcNAc-alpha-1-P-Ser residues." [GOC:mah]
subset: gosubset_prok
synonym: "protein amino acid phosphate-linked glycosylation via serine" EXACT [GOC:bf]
is_a: GO:0042076 ! protein phosphate-linked glycosylation

[Term]
id: GO:0042078
name: germ-line stem cell division
namespace: biological_process
alt_id: GO:0048131
def: "The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes." [GOC:jid, PMID:2279698]
synonym: "germ-line stem cell renewal" EXACT []
is_a: GO:0017145 ! stem cell division
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
relationship: part_of GO:0007281 ! germ cell development

[Term]
id: GO:0042079
name: obsolete GPI/GSI anchor metabolic process
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it is a composite term that represents two individual processes.
synonym: "GPI/GSI anchor metabolic process" EXACT []
is_obsolete: true
consider: GO:0006505
consider: GO:0042081

[Term]
id: GO:0042080
name: obsolete GPI/GSI anchor biosynthetic process
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it is a composite term that represents two individual processes.
synonym: "GPI/GSI anchor anabolism" EXACT []
synonym: "GPI/GSI anchor biosynthesis" EXACT []
synonym: "GPI/GSI anchor biosynthetic process" EXACT []
synonym: "GPI/GSI anchor formation" EXACT []
synonym: "GPI/GSI anchor synthesis" EXACT []
is_obsolete: true
consider: GO:0006506
consider: GO:0042082

[Term]
id: GO:0042081
name: GSI anchor metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycosylsphingolipidinositol (GSI) anchors, which attach membrane proteins to the lipid bilayer of the cell membrane." [GOC:go_curators]
subset: gosubset_prok
synonym: "GPI/GSI anchor metabolic process" BROAD []
synonym: "GPI/GSI anchor metabolism" BROAD []
synonym: "GSI anchor metabolism" EXACT []
is_a: GO:0006687 ! glycosphingolipid metabolic process

[Term]
id: GO:0042082
name: GSI anchor biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a glycosylsphingolipidinositol (GSI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The sphingolipid group is linked, via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via a ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GSI anchors have variants on this canonical linkage." [GOC:go_curators, GOC:jsg]
subset: gosubset_prok
synonym: "GPI/GSI anchor biosynthesis" BROAD []
synonym: "GPI/GSI anchor biosynthetic process" BROAD []
synonym: "GSI anchor anabolism" EXACT []
synonym: "GSI anchor biosynthesis" EXACT []
synonym: "GSI anchor formation" EXACT []
synonym: "GSI anchor synthesis" EXACT []
is_a: GO:0006497 ! protein lipidation
is_a: GO:0006688 ! glycosphingolipid biosynthetic process
is_a: GO:0042081 ! GSI anchor metabolic process

[Term]
id: GO:0042083
name: 5,10-methylenetetrahydrofolate-dependent methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5,10-methylenetetrahydrofolate." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0042084
name: 5-methyltetrahydrofolate-dependent methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5-methyltetrahydrofolate." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0042085
name: 5-methyltetrahydropteroyltri-L-glutamate-dependent methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5-methyltetrahydropteroyltri-L-glutamate." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0042086
name: 5-methyl-5,6,7,8-tetrahydromethanopterin-dependent methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group to an acceptor molecule, dependent on the presence of 5-methyl-5,6,7,8-tetrahydromethanopterin." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0042088
name: T-helper 1 type immune response
namespace: biological_process
def: "An immune response which is associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis, and which is typically orchestrated by the production of particular cytokines by T-helper 1 cells, most notably interferon-gamma, IL-2, and lymphotoxin." [GOC:add, ISBN:0781735149]
synonym: "Th1 immune response" EXACT []
is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

[Term]
id: GO:0042089
name: cytokine biosynthetic process
namespace: biological_process
alt_id: GO:0042032
def: "The chemical reactions and pathways resulting in the formation of cytokines, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity." [GOC:bf, ISBN:0198506732, ISBN:0198599471]
synonym: "cytokine anabolism" EXACT []
synonym: "cytokine biosynthesis" EXACT []
synonym: "cytokine formation" EXACT []
synonym: "cytokine synthesis" EXACT []
synonym: "induction of cytokines" NARROW []
is_a: GO:0042107 ! cytokine metabolic process
relationship: part_of GO:0001816 ! cytokine production

[Term]
id: GO:0042090
name: interleukin-12 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-12." [GOC:go_curators]
synonym: "IL-12 biosynthesis" EXACT []
synonym: "IL-12 biosynthetic process" EXACT []
synonym: "interleukin-12 anabolism" EXACT []
synonym: "interleukin-12 biosynthesis" EXACT []
synonym: "interleukin-12 formation" EXACT []
synonym: "interleukin-12 synthesis" EXACT []
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032615 ! interleukin-12 production

[Term]
id: GO:0042091
name: interleukin-10 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-10." [GOC:go_curators]
synonym: "IL-10 biosynthesis" EXACT []
synonym: "IL-10 biosynthetic process" EXACT []
synonym: "interleukin-10 anabolism" EXACT []
synonym: "interleukin-10 biosynthesis" EXACT []
synonym: "interleukin-10 formation" EXACT []
synonym: "interleukin-10 synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032613 ! interleukin-10 production

[Term]
id: GO:0042092
name: type 2 immune response
namespace: biological_process
def: "An immune response which is associated with resistance to extracellular organisms such as helminths and pathological conditions such as allergy, which is orchestrated by the production of particular cytokines, most notably IL-4, IL-5, IL-10, and IL-13, by any of a variety of cell types including T-helper 2 cells, eosinophils, basophils, mast cells, and nuocytes, resulting in enhanced production of certain antibody isotypes and other effects." [GOC:add, ISBN:0781735149, PMID:18000958, PMID:18007680, PMID:20065995, PMID:20200518]
synonym: "T-helper 2 type immune response" NARROW [GOC:add]
synonym: "Th2 immune response" NARROW [GOC:add]
is_a: GO:0006955 ! immune response

[Term]
id: GO:0042093
name: T-helper cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized thymocyte acquires specialized features of a T-helper cell." [GOC:ebc]
synonym: "helper T cell differentiation" EXACT [CL:0000912]
synonym: "T-helper cell development" RELATED [GOC:add]
is_a: GO:0002294 ! CD4-positive, alpha-beta T cell differentiation involved in immune response

[Term]
id: GO:0042094
name: interleukin-2 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-2." [GOC:go_curators]
synonym: "IL-2 biosynthesis" EXACT []
synonym: "IL-2 biosynthetic process" EXACT []
synonym: "interleukin-2 anabolism" EXACT []
synonym: "interleukin-2 biosynthesis" EXACT []
synonym: "interleukin-2 formation" EXACT []
synonym: "interleukin-2 synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032623 ! interleukin-2 production

[Term]
id: GO:0042095
name: interferon-gamma biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interferon-gamma. Interferon gamma is the only member of the type II interferon found so far." [GOC:go_curators, PR:000000017]
synonym: "IFN-gamma biosynthesis" EXACT []
synonym: "IFN-gamma biosynthetic process" EXACT []
synonym: "interferon type II biosynthesis" BROAD []
synonym: "interferon type II biosynthetic process" BROAD []
synonym: "interferon-gamma anabolism" EXACT []
synonym: "interferon-gamma biosynthesis" EXACT []
synonym: "interferon-gamma formation" EXACT []
synonym: "interferon-gamma synthesis" EXACT []
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032609 ! interferon-gamma production

[Term]
id: GO:0042096
name: obsolete alpha-beta T cell receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it describes a receptor type, and not an activity.
synonym: "alpha-beta T cell receptor activity" EXACT []
is_obsolete: true
consider: GO:0032394
consider: GO:0032395
consider: GO:0042605

[Term]
id: GO:0042097
name: interleukin-4 biosynthetic process
namespace: biological_process
alt_id: GO:0042224
def: "The chemical reactions and pathways resulting in the formation of interleukin-4." [GOC:go_curators]
synonym: "IL-4 biosynthesis" EXACT []
synonym: "IL-4 biosynthetic process" EXACT []
synonym: "interleukin-4 anabolism" EXACT []
synonym: "interleukin-4 biosynthesis" EXACT []
synonym: "interleukin-4 formation" EXACT []
synonym: "interleukin-4 synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032633 ! interleukin-4 production

[Term]
id: GO:0042098
name: T cell proliferation
namespace: biological_process
alt_id: GO:0042111
def: "The expansion of a T cell population by cell division. Follows T cell activation." [GOC:jl]
synonym: "T lymphocyte proliferation" EXACT []
synonym: "T-cell proliferation" EXACT []
synonym: "T-lymphocyte proliferation" EXACT []
is_a: GO:0042110 ! T cell activation
is_a: GO:0046651 ! lymphocyte proliferation

[Term]
id: GO:0042099
name: obsolete gamma-delta T cell receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it describes a receptor type, and not an activity.
synonym: "gamma-delta T cell receptor activity" EXACT []
is_obsolete: true
consider: GO:0032394
consider: GO:0032395
consider: GO:0042605

[Term]
id: GO:0042100
name: B cell proliferation
namespace: biological_process
alt_id: GO:0042114
def: "The expansion of a B cell population by cell division. Follows B cell activation." [GOC:jl]
synonym: "B lymphocyte proliferation" EXACT []
synonym: "B-cell proliferation" EXACT []
synonym: "B-lymphocyte proliferation" EXACT []
is_a: GO:0042113 ! B cell activation
is_a: GO:0046651 ! lymphocyte proliferation

[Term]
id: GO:0042101
name: T cell receptor complex
namespace: cellular_component
def: "A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains." [GOC:mah, ISBN:0781735149]
synonym: "T lymphocyte receptor complex" EXACT []
synonym: "T-cell receptor complex" EXACT []
synonym: "T-lymphocyte receptor complex" EXACT []
synonym: "TCR" RELATED []
synonym: "TCR complex" EXACT [GOC:bf]
xref: Wikipedia:T_cell_receptor
is_a: GO:0098802 ! plasma membrane receptor complex

[Term]
id: GO:0042102
name: positive regulation of T cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of T cell proliferation." [GOC:ai]
synonym: "activation of T cell proliferation" NARROW []
synonym: "positive regulation of T lymphocyte proliferation" EXACT []
synonym: "positive regulation of T-lymphocyte proliferation" EXACT []
synonym: "stimulation of T cell proliferation" NARROW []
synonym: "up regulation of T cell proliferation" EXACT []
synonym: "up-regulation of T cell proliferation" EXACT []
synonym: "upregulation of T cell proliferation" EXACT []
is_a: GO:0042129 ! regulation of T cell proliferation
is_a: GO:0050671 ! positive regulation of lymphocyte proliferation
is_a: GO:0050870 ! positive regulation of T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042098 ! T cell proliferation
relationship: positively_regulates GO:0042098 ! T cell proliferation

[Term]
id: GO:0042103
name: positive regulation of T cell homeostatic proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of resting T cell proliferation." [GOC:jl]
synonym: "activation of T cell homeostatic proliferation" NARROW []
synonym: "positive regulation of resting T cell proliferation" EXACT []
synonym: "positive regulation of T lymphocyte homeostatic proliferation" EXACT []
synonym: "positive regulation of T-cell homeostatic proliferation" EXACT []
synonym: "positive regulation of T-lymphocyte homeostatic proliferation" EXACT []
synonym: "stimulation of T cell homeostatic proliferation" NARROW []
synonym: "up regulation of T cell homeostatic proliferation" EXACT []
synonym: "up-regulation of T cell homeostatic proliferation" EXACT []
synonym: "upregulation of T cell homeostatic proliferation" EXACT []
is_a: GO:0032846 ! positive regulation of homeostatic process
is_a: GO:0042102 ! positive regulation of T cell proliferation
is_a: GO:0046013 ! regulation of T cell homeostatic proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001777 ! T cell homeostatic proliferation
relationship: positively_regulates GO:0001777 ! T cell homeostatic proliferation

[Term]
id: GO:0042104
name: positive regulation of activated T cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of activated T cell proliferation." [GOC:jl]
synonym: "activation of activated T cell proliferation" NARROW []
synonym: "positive regulation of activated T lymphocyte proliferation" EXACT []
synonym: "positive regulation of activated T-cell proliferation" EXACT []
synonym: "positive regulation of activated T-lymphocyte proliferation" EXACT []
synonym: "stimulation of activated T cell proliferation" NARROW []
synonym: "up regulation of activated T cell proliferation" EXACT []
synonym: "up-regulation of activated T cell proliferation" EXACT []
synonym: "upregulation of activated T cell proliferation" EXACT []
is_a: GO:0042102 ! positive regulation of T cell proliferation
is_a: GO:0046006 ! regulation of activated T cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0050798 ! activated T cell proliferation
relationship: positively_regulates GO:0050798 ! activated T cell proliferation

[Term]
id: GO:0042105
name: alpha-beta T cell receptor complex
namespace: cellular_component
def: "A T cell receptor complex in which the TCR heterodimer comprises alpha and beta chains, associated with the CD3 complex; recognizes a complex consisting of an antigen-derived peptide bound to a class I or class II MHC protein." [GOC:mah, ISBN:0781735149]
synonym: "alpha-beta T lymphocyte receptor complex" EXACT []
synonym: "alpha-beta T-cell receptor complex" EXACT []
synonym: "alpha-beta T-lymphocyte receptor complex" EXACT []
synonym: "alpha-beta TCR complex" EXACT []
is_a: GO:0042101 ! T cell receptor complex

[Term]
id: GO:0042106
name: gamma-delta T cell receptor complex
namespace: cellular_component
def: "A T cell receptor complex in which the TCR heterodimer comprises gamma and delta chains, associated with the CD3 complex; recognizes antigen directly, without a requirement for processing and presentation by an MHC protein." [GOC:mah, ISBN:0781735149]
synonym: "gamma-delta T lymphocyte receptor complex" EXACT []
synonym: "gamma-delta T-cell receptor complex" EXACT []
synonym: "gamma-delta T-lymphocyte receptor complex" EXACT []
synonym: "gamma-delta TCR complex" EXACT []
is_a: GO:0042101 ! T cell receptor complex

[Term]
id: GO:0042107
name: cytokine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cytokines, any of a group of proteins or glycoproteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity." [GO_REF:0000022, GOC:bf, GOC:BHF, GOC:go_curators, GOC:mtg_15nov05, ISBN:0198599471]
comment: This term was improved by GO_REF:0000022. It was moved.
synonym: "cytokine metabolism" EXACT []
is_a: GO:0019538 ! protein metabolic process

[Term]
id: GO:0042108
name: positive regulation of cytokine biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines." [GOC:go_curators]
synonym: "activation of cytokine biosynthetic process" NARROW []
synonym: "positive regulation of cytokine anabolism" EXACT []
synonym: "positive regulation of cytokine biosynthesis" EXACT []
synonym: "positive regulation of cytokine formation" EXACT []
synonym: "positive regulation of cytokine synthesis" EXACT []
synonym: "stimulation of cytokine biosynthetic process" NARROW []
synonym: "up regulation of cytokine biosynthetic process" EXACT []
synonym: "up-regulation of cytokine biosynthetic process" EXACT []
synonym: "upregulation of cytokine biosynthetic process" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
is_a: GO:0051247 ! positive regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042089 ! cytokine biosynthetic process
relationship: positively_regulates GO:0042089 ! cytokine biosynthetic process

[Term]
id: GO:0042109
name: lymphotoxin A biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the cytokine lymphotoxin A." [GOC:jl]
synonym: "LTA biosynthesis" BROAD []
synonym: "LTA biosynthetic process" BROAD []
synonym: "lymphotoxin A anabolism" EXACT []
synonym: "lymphotoxin A biosynthesis" EXACT []
synonym: "lymphotoxin A formation" EXACT []
synonym: "lymphotoxin A synthesis" EXACT []
synonym: "lymphotoxin-alpha biosynthesis" EXACT []
synonym: "lymphotoxin-alpha biosynthetic process" EXACT []
synonym: "TNF-B biosynthesis" EXACT []
synonym: "TNF-B biosynthetic process" EXACT []
synonym: "TNF-beta biosynthesis" EXACT []
synonym: "TNF-beta biosynthetic process" EXACT []
synonym: "tumor necrosis factor-beta biosynthesis" EXACT []
synonym: "tumor necrosis factor-beta biosynthetic process" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032641 ! lymphotoxin A production

[Term]
id: GO:0042110
name: T cell activation
namespace: biological_process
def: "The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:mgi_curators, ISBN:0781735140]
synonym: "T lymphocyte activation" EXACT []
synonym: "T-cell activation" EXACT []
synonym: "T-lymphocyte activation" EXACT []
is_a: GO:0046649 ! lymphocyte activation
is_a: GO:0070489 ! T cell aggregation

[Term]
id: GO:0042113
name: B cell activation
namespace: biological_process
def: "The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:mgi_curators, ISBN:0781735140]
synonym: "B lymphocyte activation" EXACT []
synonym: "B-cell activation" EXACT []
synonym: "B-lymphocyte activation" EXACT []
is_a: GO:0046649 ! lymphocyte activation

[Term]
id: GO:0042116
name: macrophage activation
namespace: biological_process
def: "A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149, PMID:14506301]
is_a: GO:0002274 ! myeloid leukocyte activation

[Term]
id: GO:0042117
name: monocyte activation
namespace: biological_process
def: "The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149]
is_a: GO:0002274 ! myeloid leukocyte activation

[Term]
id: GO:0042118
name: endothelial cell activation
namespace: biological_process
def: "The change in morphology and behavior of an endothelial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149, PMID:12851652, PMID:14581484]
is_a: GO:0001775 ! cell activation

[Term]
id: GO:0042119
name: neutrophil activation
namespace: biological_process
def: "The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149]
is_a: GO:0036230 ! granulocyte activation

[Term]
id: GO:0042120
name: alginic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds)." [ISBN:0198506732]
subset: gosubset_prok
synonym: "alginate metabolic process" EXACT []
synonym: "alginate metabolism" EXACT []
synonym: "alginic acid metabolism" EXACT []
is_a: GO:0019752 ! carboxylic acid metabolic process
is_a: GO:0044264 ! cellular polysaccharide metabolic process
is_a: GO:0044723 ! single-organism carbohydrate metabolic process

[Term]
id: GO:0042121
name: alginic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds)." [ISBN:0198506732]
subset: gosubset_prok
synonym: "alginate biosynthesis" EXACT []
synonym: "alginate biosynthetic process" EXACT []
synonym: "alginic acid anabolism" EXACT []
synonym: "alginic acid biosynthesis" EXACT []
synonym: "alginic acid formation" EXACT []
synonym: "alginic acid synthesis" EXACT []
is_a: GO:0033692 ! cellular polysaccharide biosynthetic process
is_a: GO:0042120 ! alginic acid metabolic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process

[Term]
id: GO:0042122
name: alginic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds)." [ISBN:0198506732]
subset: gosubset_prok
synonym: "alginate catabolic process" EXACT []
synonym: "alginate catabolism" EXACT []
synonym: "alginic acid breakdown" EXACT []
synonym: "alginic acid catabolism" EXACT []
synonym: "alginic acid degradation" EXACT []
is_a: GO:0042120 ! alginic acid metabolic process
is_a: GO:0044247 ! cellular polysaccharide catabolic process
is_a: GO:0044724 ! single-organism carbohydrate catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process

[Term]
id: GO:0042123
name: glucanosyltransferase activity
namespace: molecular_function
def: "Catalysis of the splitting and linkage of glucan molecules, resulting in glucan chain elongation." [GOC:jl]
is_a: GO:0016740 ! transferase activity

[Term]
id: GO:0042124
name: 1,3-beta-glucanosyltransferase activity
namespace: molecular_function
def: "Catalysis of the splitting and linkage of (1->3)-beta-D-glucan molecules, resulting in (1->3)-beta-D-glucan chain elongation." [GOC:jl, PMID:10809732]
is_a: GO:0042123 ! glucanosyltransferase activity

[Term]
id: GO:0042125
name: protein galactosylation
namespace: biological_process
def: "The addition of a galactose molecule to a protein amino acid." [GOC:jl, GOC:pr]
subset: gosubset_prok
synonym: "protein amino acid galactosylation" EXACT [GOC:bf]
is_a: GO:0006486 ! protein glycosylation
is_a: GO:0044262 ! cellular carbohydrate metabolic process

[Term]
id: GO:0042126
name: nitrate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nitrates, inorganic or organic salts and esters of nitric acid." [GOC:jl]
subset: gosubset_prok
synonym: "nitrate metabolism" EXACT []
is_a: GO:0043436 ! oxoacid metabolic process
is_a: GO:2001057 ! reactive nitrogen species metabolic process

[Term]
id: GO:0042127
name: regulation of cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl]
subset: gosubset_prok
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008283 ! cell proliferation
relationship: regulates GO:0008283 ! cell proliferation

[Term]
id: GO:0042128
name: nitrate assimilation
namespace: biological_process
def: "The nitrogen metabolic process that encompasses the uptake of nitrate from the environment and reduction to ammonia, and results in the incorporation of nitrogen derived from nitrate into cellular substances." [GOC:das, GOC:mah, PMID:10542156, PMID:8122899]
subset: gosubset_prok
synonym: "assimilatory nitrate reduction" EXACT []
xref: MetaCyc:PWY-381
is_a: GO:0042126 ! nitrate metabolic process
is_a: GO:0071941 ! nitrogen cycle metabolic process

[Term]
id: GO:0042129
name: regulation of T cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of T cell proliferation." [GOC:jl]
synonym: "regulation of T lymphocyte proliferation" EXACT []
synonym: "regulation of T-cell proliferation" EXACT []
synonym: "regulation of T-lymphocyte proliferation" EXACT []
is_a: GO:0050670 ! regulation of lymphocyte proliferation
is_a: GO:0050863 ! regulation of T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042098 ! T cell proliferation
relationship: regulates GO:0042098 ! T cell proliferation

[Term]
id: GO:0042130
name: negative regulation of T cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of T cell proliferation." [GOC:jl]
synonym: "down regulation of T cell proliferation" EXACT []
synonym: "down-regulation of T cell proliferation" EXACT []
synonym: "downregulation of T cell proliferation" EXACT []
synonym: "inhibition of T cell proliferation" NARROW []
synonym: "negative regulation of T lymphocyte proliferation" EXACT []
synonym: "negative regulation of T-cell proliferation" EXACT []
synonym: "negative regulation of T-lymphocyte proliferation" EXACT []
is_a: GO:0042129 ! regulation of T cell proliferation
is_a: GO:0050672 ! negative regulation of lymphocyte proliferation
is_a: GO:0050868 ! negative regulation of T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042098 ! T cell proliferation
relationship: negatively_regulates GO:0042098 ! T cell proliferation

[Term]
id: GO:0042131
name: thiamine phosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: thiamine phosphate + H2O = thiamine + phosphate." [PMID:197075]
synonym: "thiamin monophosphate phosphatase" EXACT []
synonym: "thiamin phosphate phosphatase activity" EXACT [GOC:curators]
synonym: "ThMPase" EXACT []
is_a: GO:0003993 ! acid phosphatase activity

[Term]
id: GO:0042132
name: fructose 1,6-bisphosphate 1-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate." [EC:3.1.3.11]
subset: gosubset_prok
synonym: "D-fructose 1,6-diphosphatase activity" EXACT [EC:3.1.3.11]
synonym: "D-fructose-1,6-bisphosphate 1-phosphohydrolase activity" EXACT [EC:3.1.3.11]
synonym: "D-fructose-1,6-bisphosphate phosphatase activity" EXACT [EC:3.1.3.11]
synonym: "FBPase activity" EXACT [EC:3.1.3.11]
synonym: "fructose 1,6-bisphosphatase activity" EXACT [EC:3.1.3.11]
synonym: "fructose 1,6-bisphosphate phosphatase activity" EXACT [EC:3.1.3.11]
synonym: "fructose 1,6-diphosphatase activity" EXACT [EC:3.1.3.11]
synonym: "fructose 1,6-diphosphate phosphatase activity" EXACT [EC:3.1.3.11]
synonym: "fructose bisphosphate phosphatase activity" EXACT [EC:3.1.3.11]
synonym: "fructose diphosphatase activity" EXACT [EC:3.1.3.11]
synonym: "fructose diphosphate phosphatase activity" EXACT [EC:3.1.3.11]
synonym: "fructose-1,6-bisphosphatase activity" EXACT [EC:3.1.3.11]
synonym: "fructose-bisphosphatase activity" BROAD [EC:3.1.3.00]
synonym: "hexose bisphosphatase activity" EXACT [EC:3.1.3.11]
synonym: "hexose diphosphatase activity" EXACT [EC:3.1.3.11]
synonym: "hexosediphosphatase activity" BROAD [EC:3.1.3.11]
xref: EC:3.1.3.11
xref: MetaCyc:F16BDEPHOS-RXN
xref: Reactome:REACT_106202 "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate, Canis familiaris"
xref: Reactome:REACT_109736 "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate, Rattus norvegicus"
xref: Reactome:REACT_110688 "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_110892 "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate, Arabidopsis thaliana"
xref: Reactome:REACT_110923 "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_113175 "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate, Escherichia coli"
xref: Reactome:REACT_115804 "fructose 1,6-bisphosphate + H2O => fructose 6-phosphate + orthophosphate, Gallus gallus"
xref: Reactome:REACT_30220 "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate, Bos taurus"
xref: Reactome:REACT_379 "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate, Homo sapiens"
xref: Reactome:REACT_80357 "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate, Mus musculus"
xref: Reactome:REACT_88781 "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate, Sus scrofa"
xref: Reactome:REACT_88813 "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate, Gallus gallus"
xref: Reactome:REACT_89554 "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate, Danio rerio"
xref: Reactome:REACT_89796 "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate, Xenopus tropicalis"
xref: Reactome:REACT_91418 "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_93092 "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate, Drosophila melanogaster"
xref: Reactome:REACT_95147 "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate, Caenorhabditis elegans"
xref: Reactome:REACT_98324 "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate, Oryza sativa"
xref: Reactome:REACT_99119 "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate, Taeniopygia guttata"
xref: RHEA:11067
is_a: GO:0050308 ! sugar-phosphatase activity

[Term]
id: GO:0042133
name: neurotransmitter metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving neurotransmitters, any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell." [CHEBI:25512, GOC:jl]
subset: goslim_pir
synonym: "neurotransmitter metabolism" EXACT []
xref: Reactome:REACT_100207 "Metabolism of Noradrenaline, Danio rerio"
xref: Reactome:REACT_101077 "Metabolism of Noradrenaline, Taeniopygia guttata"
xref: Reactome:REACT_103666 "Metabolism of Noradrenaline, Rattus norvegicus"
xref: Reactome:REACT_104729 "Metabolism of Noradrenaline, Xenopus tropicalis"
xref: Reactome:REACT_108898 "Metabolism of Noradrenaline, Canis familiaris"
xref: Reactome:REACT_115498 "Metabolism of Noradrenaline, Dictyostelium discoideum"
xref: Reactome:REACT_15390 "Metabolism of Noradrenaline, Homo sapiens"
xref: Reactome:REACT_57518 "Metabolism of Noradrenaline, Gallus gallus"
xref: Reactome:REACT_87838 "Metabolism of Noradrenaline, Bos taurus"
xref: Reactome:REACT_90506 "Metabolism of Noradrenaline, Mycobacterium tuberculosis"
xref: Reactome:REACT_94583 "Metabolism of Noradrenaline, Sus scrofa"
xref: Reactome:REACT_99002 "Metabolism of Noradrenaline, Mus musculus"
is_a: GO:0001505 ! regulation of neurotransmitter levels
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0042134
name: rRNA primary transcript binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an unprocessed ribosomal RNA transcript." [GOC:jl]
is_a: GO:0019843 ! rRNA binding

[Term]
id: GO:0042135
name: neurotransmitter catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell." [CHEBI:25512, GOC:jl]
synonym: "neurotransmitter breakdown" EXACT []
synonym: "neurotransmitter catabolism" EXACT []
synonym: "neurotransmitter degradation" EXACT []
is_a: GO:0042133 ! neurotransmitter metabolic process
is_a: GO:0044248 ! cellular catabolic process

[Term]
id: GO:0042136
name: neurotransmitter biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell." [CHEBI:25512, GOC:jl]
synonym: "neurotransmitter anabolism" EXACT []
synonym: "neurotransmitter biosynthesis" EXACT []
synonym: "neurotransmitter biosynthesis and storage" BROAD []
synonym: "neurotransmitter biosynthetic process and storage" BROAD []
synonym: "neurotransmitter formation" EXACT []
synonym: "neurotransmitter synthesis" EXACT []
xref: Reactome:REACT_101731 "Neurotransmitter Clearance In The Synaptic Cleft, Sus scrofa"
xref: Reactome:REACT_107523 "Neurotransmitter Clearance In The Synaptic Cleft, Schizosaccharomyces pombe"
xref: Reactome:REACT_108610 "Neurotransmitter Clearance In The Synaptic Cleft, Mycobacterium tuberculosis"
xref: Reactome:REACT_108742 "Neurotransmitter Clearance In The Synaptic Cleft, Caenorhabditis elegans"
xref: Reactome:REACT_110245 "Neurotransmitter Clearance In The Synaptic Cleft, Xenopus tropicalis"
xref: Reactome:REACT_112396 "Neurotransmitter Clearance In The Synaptic Cleft, Escherichia coli"
xref: Reactome:REACT_115066 "Neurotransmitter Clearance In The Synaptic Cleft, Dictyostelium discoideum"
xref: Reactome:REACT_13583 "Neurotransmitter Clearance In The Synaptic Cleft, Homo sapiens"
xref: Reactome:REACT_28513 "Neurotransmitter Clearance In The Synaptic Cleft, Taeniopygia guttata"
xref: Reactome:REACT_77139 "Neurotransmitter Clearance In The Synaptic Cleft, Rattus norvegicus"
xref: Reactome:REACT_81660 "Neurotransmitter Clearance In The Synaptic Cleft, Arabidopsis thaliana"
xref: Reactome:REACT_82622 "Neurotransmitter Clearance In The Synaptic Cleft, Bos taurus"
xref: Reactome:REACT_83009 "Neurotransmitter Clearance In The Synaptic Cleft, Gallus gallus"
xref: Reactome:REACT_89303 "Neurotransmitter Clearance In The Synaptic Cleft, Oryza sativa"
xref: Reactome:REACT_93349 "Neurotransmitter Clearance In The Synaptic Cleft, Danio rerio"
xref: Reactome:REACT_99114 "Neurotransmitter Clearance In The Synaptic Cleft, Drosophila melanogaster"
xref: Reactome:REACT_99596 "Neurotransmitter Clearance In The Synaptic Cleft, Mus musculus"
xref: Reactome:REACT_99804 "Neurotransmitter Clearance In The Synaptic Cleft, Canis familiaris"
is_a: GO:0042133 ! neurotransmitter metabolic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0042137
name: sequestering of neurotransmitter
namespace: biological_process
def: "The process of binding or confining a neurotransmitter such that it is separated from other components of a biological system." [GOC:ai]
synonym: "neurotransmitter biosynthesis and storage" RELATED []
synonym: "neurotransmitter biosynthetic process and storage" RELATED []
synonym: "neurotransmitter retention" EXACT []
synonym: "neurotransmitter sequestration" EXACT []
synonym: "neurotransmitter storage" EXACT []
synonym: "retention of neurotransmitter" EXACT []
synonym: "sequestration of neurotransmitter" EXACT []
synonym: "storage of neurotransmitter" EXACT []
is_a: GO:0001505 ! regulation of neurotransmitter levels
is_a: GO:0051235 ! maintenance of location

[Term]
id: GO:0042138
name: meiotic DNA double-strand break formation
namespace: biological_process
def: "The cell cycle process in which double-strand breaks are generated at defined hotspots throughout the genome during meiosis I. This results in the initiation of meiotic recombination." [GOC:elh, GOC:jl, PMID:11529427]
is_a: GO:0044710 ! single-organism metabolic process
is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0007127 ! meiosis I

[Term]
id: GO:0042139
name: early meiotic recombination nodule assembly
namespace: biological_process
def: "During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form small, electron dense structures in association with meiotic chromosomes during leptotene and zygotene." [GOC:jl, PMID:9334324]
is_a: GO:0007146 ! meiotic recombination nodule assembly

[Term]
id: GO:0042140
name: late meiotic recombination nodule assembly
namespace: biological_process
def: "During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form small, electron dense structures in association with meiotic chromosomes during pachytene. Involved in the catalysis crossing over." [GOC:jl, PMID:9334324]
is_a: GO:0007146 ! meiotic recombination nodule assembly

[Term]
id: GO:0042141
name: obsolete mating pheromone exporter
namespace: molecular_function
def: "OBSOLETE. Exports diffusible peptide signals that are responsible for binding to other cells and triggering a series of responses to facilitate mating." [GOC:jl]
comment: This term was made obsolete because it is too gene product specific.
synonym: "mating pheromone exporter" EXACT []
is_obsolete: true
consider: GO:0042626
consider: GO:0043190

[Term]
id: GO:0042142
name: obsolete heavy metal chelation
namespace: biological_process
def: "OBSOLETE. The strong but reversible binding of a heavy metal ion by a larger molecule such as protein." [GOC:jl, ISBN:0124325653]
comment: This term was made obsolete because it represents a molecular function and not a biological process.
synonym: "heavy metal chelation" EXACT []
is_obsolete: true
replaced_by: GO:0046911

[Term]
id: GO:0042144
name: vacuole fusion, non-autophagic
namespace: biological_process
alt_id: GO:0042145
def: "The fusion of two vacuole membranes to form a single vacuole." [GOC:jl]
synonym: "homotypic vacuole fusion" EXACT []
synonym: "homotypic vacuole fusion (non-autophagic)" EXACT []
synonym: "homotypic vacuole fusion, non-autophagic" EXACT []
synonym: "vacuole fusion (non-autophagic)" EXACT []
is_a: GO:0044801 ! single-organism membrane fusion
is_a: GO:0097576 ! vacuole fusion
is_a: GO:1902589 ! single-organism organelle organization

[Term]
id: GO:0042147
name: retrograde transport, endosome to Golgi
namespace: biological_process
def: "The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]
synonym: "retrograde (endosome to Golgi) transport" EXACT []
is_a: GO:0016192 ! vesicle-mediated transport
is_a: GO:0016197 ! endosomal transport
is_a: GO:0016482 ! cytosolic transport
relationship: occurs_in GO:0005829 ! cytosol

[Term]
id: GO:0042148
name: strand invasion
namespace: biological_process
def: "The process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules." [GOC:elh, PMID:10357855]
synonym: "D-loop biosynthesis" RELATED []
synonym: "D-loop formation" RELATED []
synonym: "displacement loop biosynthesis" RELATED [GOC:mah, GOC:vw]
synonym: "displacement loop formation" RELATED [GOC:mah, GOC:vw]
synonym: "Rad51-mediated strand invasion" EXACT [GOC:elh]
is_a: GO:0006259 ! DNA metabolic process
relationship: part_of GO:0006310 ! DNA recombination

[Term]
id: GO:0042149
name: cellular response to glucose starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose." [GOC:jl]
is_a: GO:0009267 ! cellular response to starvation

[Term]
id: GO:0042150
name: plasmid recombination
namespace: biological_process
def: "A process of DNA recombination occurring within a plasmid or between plasmids and other plasmids or DNA molecules." [GOC:mlg]
subset: gosubset_prok
is_a: GO:0006310 ! DNA recombination

[Term]
id: GO:0042151
name: nematocyst
namespace: cellular_component
def: "An organelle found in cnidoblast (nematoblast) cells. When matured, these stinging organelles store toxins and can deliver them when the cnidocil (a short extension of the cnidocyst) is stimulated by a prey or another stimulus." [DOI:10.1139/z02-135, GOC:jl]
synonym: "cnidocyst" EXACT []
xref: Wikipedia:Cnidocyte
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle
is_a: GO:0044448 ! cell cortex part

[Term]
id: GO:0042152
name: RNA-mediated DNA recombination
namespace: biological_process
def: "The reverse transcription of an RNA molecule followed by recombination between the resultant cDNA and its homologous chromosomal allele." [GOC:jl, PMID:8380627]
subset: gosubset_prok
is_a: GO:0006310 ! DNA recombination

[Term]
id: GO:0042153
name: obsolete RPTP-like protein binding
namespace: molecular_function
def: "OBSOLETE. Interacting selectively and non-covalently with proteins with similar structure/function to receptor protein tyrosine phosphatases." [GOC:jl]
comment: This term was made obsolete because it represents binding to an individual protein.
synonym: "receptor protein tyrosine phosphatase-like protein binding" EXACT []
synonym: "RPTP-like protein binding" EXACT []
is_obsolete: true
replaced_by: GO:0005515

[Term]
id: GO:0042156
name: obsolete zinc-mediated transcriptional activator activity
namespace: molecular_function
def: "OBSOLETE. Initiates or upregulates transcription in the presence of zinc." [GOC:jl]
comment: This term was obsoleted because it is defined as a Process term, i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
synonym: "zinc-mediated transcriptional activator activity" EXACT []
is_obsolete: true

[Term]
id: GO:0042157
name: lipoprotein metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids." [ISBN:0198506732]
subset: gosubset_prok
synonym: "lipoprotein metabolism" EXACT []
xref: Reactome:REACT_101960 "apolipoprotein(a) + LDL => Lp(a), Gallus gallus"
xref: Reactome:REACT_102413 "HDL-mediated lipid transport, Caenorhabditis elegans"
xref: Reactome:REACT_102496 "Chylomicron-mediated lipid transport, Sus scrofa"
xref: Reactome:REACT_103493 "Chylomicron-mediated lipid transport, Taeniopygia guttata"
xref: Reactome:REACT_105868 "Chylomicron-mediated lipid transport, Mus musculus"
xref: Reactome:REACT_107056 "Lipoprotein metabolism, Oryza sativa"
xref: Reactome:REACT_110247 "HDL-mediated lipid transport, Danio rerio"
xref: Reactome:REACT_110573 "Lipoprotein metabolism, Taeniopygia guttata"
xref: Reactome:REACT_112911 "apolipoprotein(a) + LDL => Lp(a), Xenopus tropicalis"
xref: Reactome:REACT_13621 "HDL-mediated lipid transport, Homo sapiens"
xref: Reactome:REACT_28841 "Lipoprotein metabolism, Drosophila melanogaster"
xref: Reactome:REACT_29288 "Chylomicron-mediated lipid transport, Rattus norvegicus"
xref: Reactome:REACT_33886 "HDL-mediated lipid transport, Arabidopsis thaliana"
xref: Reactome:REACT_59602 "Lipoprotein metabolism, Rattus norvegicus"
xref: Reactome:REACT_6823 "Lipoprotein metabolism, Homo sapiens"
xref: Reactome:REACT_6841 "Chylomicron-mediated lipid transport, Homo sapiens"
xref: Reactome:REACT_6958 "apolipoprotein(a) + LDL => Lp(a), Homo sapiens"
xref: Reactome:REACT_73884 "HDL-mediated lipid transport, Canis familiaris"
xref: Reactome:REACT_78284 "apolipoprotein(a) + LDL => Lp(a), Rattus norvegicus"
xref: Reactome:REACT_79032 "HDL-mediated lipid transport, Xenopus tropicalis"
xref: Reactome:REACT_79044 "HDL-mediated lipid transport, Mus musculus"
xref: Reactome:REACT_79237 "Lipoprotein metabolism, Arabidopsis thaliana"
xref: Reactome:REACT_80334 "HDL-mediated lipid transport, Gallus gallus"
xref: Reactome:REACT_80616 "apolipoprotein(a) + LDL => Lp(a), Mus musculus"
xref: Reactome:REACT_82187 "Lipoprotein metabolism, Sus scrofa"
xref: Reactome:REACT_82188 "Lipoprotein metabolism, Bos taurus"
xref: Reactome:REACT_82533 "Chylomicron-mediated lipid transport, Gallus gallus"
xref: Reactome:REACT_83113 "HDL-mediated lipid transport, Bos taurus"
xref: Reactome:REACT_83971 "HDL-mediated lipid transport, Drosophila melanogaster"
xref: Reactome:REACT_84211 "HDL-mediated lipid transport, Sus scrofa"
xref: Reactome:REACT_84712 "Lipoprotein metabolism, Danio rerio"
xref: Reactome:REACT_85446 "Chylomicron-mediated lipid transport, Danio rerio"
xref: Reactome:REACT_85688 "Lipoprotein metabolism, Canis familiaris"
xref: Reactome:REACT_85772 "HDL-mediated lipid transport, Taeniopygia guttata"
xref: Reactome:REACT_85867 "apolipoprotein(a) + LDL => Lp(a), Taeniopygia guttata"
xref: Reactome:REACT_86142 "Lipoprotein metabolism, Xenopus tropicalis"
xref: Reactome:REACT_87119 "Chylomicron-mediated lipid transport, Canis familiaris"
xref: Reactome:REACT_88173 "Lipoprotein metabolism, Mus musculus"
xref: Reactome:REACT_88824 "Lipoprotein metabolism, Plasmodium falciparum"
xref: Reactome:REACT_90523 "apolipoprotein(a) + LDL => Lp(a), Danio rerio"
xref: Reactome:REACT_90792 "HDL-mediated lipid transport, Oryza sativa"
xref: Reactome:REACT_91134 "Lipoprotein metabolism, Gallus gallus"
xref: Reactome:REACT_91166 "apolipoprotein(a) + LDL => Lp(a), Sus scrofa"
xref: Reactome:REACT_92373 "apolipoprotein(a) + LDL => Lp(a), Bos taurus"
xref: Reactome:REACT_92731 "apolipoprotein(a) + LDL => Lp(a), Canis familiaris"
xref: Reactome:REACT_93774 "HDL-mediated lipid transport, Rattus norvegicus"
xref: Reactome:REACT_96211 "HDL-mediated lipid transport, Plasmodium falciparum"
xref: Reactome:REACT_96602 "Chylomicron-mediated lipid transport, Bos taurus"
xref: Reactome:REACT_97927 "Lipoprotein metabolism, Caenorhabditis elegans"
xref: Reactome:REACT_98591 "Chylomicron-mediated lipid transport, Xenopus tropicalis"
is_a: GO:0019538 ! protein metabolic process

[Term]
id: GO:0042158
name: lipoprotein biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids." [ISBN:0198506732]
subset: gosubset_prok
synonym: "lipoprotein anabolism" EXACT []
synonym: "lipoprotein biosynthesis" EXACT []
synonym: "lipoprotein formation" EXACT []
synonym: "lipoprotein synthesis" EXACT []
xref: Reactome:REACT_100834 "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular], Mus musculus"
xref: Reactome:REACT_101820 "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular], Bos taurus"
xref: Reactome:REACT_103581 "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular], Gallus gallus"
xref: Reactome:REACT_107441 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex, Danio rerio"
xref: Reactome:REACT_110066 "ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron, Canis familiaris"
xref: Reactome:REACT_30241 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex, Rattus norvegicus"
xref: Reactome:REACT_30451 "ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron, Mus musculus"
xref: Reactome:REACT_31956 "ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron, Bos taurus"
xref: Reactome:REACT_34229 "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular], Canis familiaris"
xref: Reactome:REACT_6813 "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular], Homo sapiens"
xref: Reactome:REACT_6908 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex, Homo sapiens"
xref: Reactome:REACT_6915 "ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron, Homo sapiens"
xref: Reactome:REACT_79155 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex, Canis familiaris"
xref: Reactome:REACT_81934 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex, Xenopus tropicalis"
xref: Reactome:REACT_84235 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex, Mus musculus"
xref: Reactome:REACT_89204 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex, Gallus gallus"
xref: Reactome:REACT_93001 "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular], Xenopus tropicalis"
xref: Reactome:REACT_95479 "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular], Sus scrofa"
xref: Reactome:REACT_95856 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex, Bos taurus"
xref: Reactome:REACT_98397 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex, Taeniopygia guttata"
is_a: GO:0034645 ! cellular macromolecule biosynthetic process
is_a: GO:0042157 ! lipoprotein metabolic process

[Term]
id: GO:0042159
name: lipoprotein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids." [ISBN:0198506732]
subset: gosubset_prok
synonym: "lipoprotein breakdown" EXACT []
synonym: "lipoprotein catabolism" EXACT []
synonym: "lipoprotein degradation" EXACT []
xref: Reactome:REACT_103659 "chylomicron remnant + apoE => chylomicron remnant:apoE complex, Danio rerio"
xref: Reactome:REACT_103753 "chylomicron remnant + apoE => chylomicron remnant:apoE complex, Mus musculus"
xref: Reactome:REACT_107956 "chylomicron remnant + apoE => chylomicron remnant:apoE complex, Bos taurus"
xref: Reactome:REACT_110096 "chylomicron remnant + apoE => chylomicron remnant:apoE complex, Sus scrofa"
xref: Reactome:REACT_6865 "chylomicron remnant + apoE => chylomicron remnant:apoE complex, Homo sapiens"
xref: Reactome:REACT_87713 "chylomicron remnant + apoE => chylomicron remnant:apoE complex, Xenopus tropicalis"
xref: Reactome:REACT_95524 "chylomicron remnant + apoE => chylomicron remnant:apoE complex, Canis familiaris"
xref: Reactome:REACT_97689 "chylomicron remnant + apoE => chylomicron remnant:apoE complex, Rattus norvegicus"
is_a: GO:0030163 ! protein catabolic process
is_a: GO:0042157 ! lipoprotein metabolic process

[Term]
id: GO:0042160
name: lipoprotein modification
namespace: biological_process
def: "The chemical reactions and pathways resulting in the covalent alteration of one or more amino acid or lipid residues occurring in a lipoprotein, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids." [GOC:mah]
subset: gosubset_prok
is_a: GO:0042157 ! lipoprotein metabolic process

[Term]
id: GO:0042161
name: lipoprotein oxidation
namespace: biological_process
def: "The modification of a lipoprotein by oxidation of one or more amino acids or the lipid group." [GOC:mah]
subset: gosubset_prok
is_a: GO:0042160 ! lipoprotein modification
is_a: GO:0055114 ! oxidation-reduction process

[Term]
id: GO:0042162
name: telomeric DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end." [GOC:jl, SO:0000624]
synonym: "telomere binding" EXACT []
synonym: "telomeric repeat binding" EXACT []
is_a: GO:0043565 ! sequence-specific DNA binding

[Term]
id: GO:0042163
name: interleukin-12 beta subunit binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the beta subunit of interleukin-12." [GOC:mah]
synonym: "CLMFp40 binding" EXACT []
synonym: "IL-12B binding" EXACT []
synonym: "IL-12p40 binding" EXACT []
synonym: "NKSFp40 binding" EXACT []
is_a: GO:0019972 ! interleukin-12 binding

[Term]
id: GO:0042164
name: interleukin-12 alpha subunit binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the alpha subunit of interleukin-12." [GOC:mah]
synonym: "CLMFp35 binding" EXACT []
synonym: "IL-12A binding" EXACT []
synonym: "IL-12p35 binding" EXACT []
synonym: "NKSFp35 binding" EXACT []
is_a: GO:0019972 ! interleukin-12 binding

[Term]
id: GO:0042165
name: neurotransmitter binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a neurotransmitter, any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [ISBN:0198506732]
subset: goslim_pir
is_a: GO:0005488 ! binding

[Term]
id: GO:0042166
name: acetylcholine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions." [GOC:ai]
is_a: GO:0042165 ! neurotransmitter binding
is_a: GO:0050997 ! quaternary ammonium group binding
is_a: GO:0070405 ! ammonium ion binding

[Term]
id: GO:0042167
name: heme catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:jl]
subset: gosubset_prok
synonym: "haem catabolic process" EXACT []
synonym: "haem catabolism" EXACT []
synonym: "heme breakdown" EXACT []
synonym: "heme catabolism" EXACT []
synonym: "heme degradation" EXACT []
xref: Reactome:REACT_104905 "Heme degradation, Gallus gallus"
xref: Reactome:REACT_109283 "Heme degradation, Mus musculus"
xref: Reactome:REACT_114440 "Heme degradation, Caenorhabditis elegans"
xref: Reactome:REACT_22297 "Heme degradation, Homo sapiens"
xref: Reactome:REACT_30840 "Heme degradation, Sus scrofa"
xref: Reactome:REACT_30849 "Heme degradation, Canis familiaris"
xref: Reactome:REACT_32633 "Heme degradation, Danio rerio"
xref: Reactome:REACT_80664 "Heme degradation, Drosophila melanogaster"
xref: Reactome:REACT_83600 "Heme degradation, Rattus norvegicus"
xref: Reactome:REACT_98093 "Heme degradation, Taeniopygia guttata"
xref: Reactome:REACT_98245 "Heme degradation, Bos taurus"
xref: Reactome:REACT_99033 "Heme degradation, Xenopus tropicalis"
is_a: GO:0006787 ! porphyrin-containing compound catabolic process
is_a: GO:0042168 ! heme metabolic process
is_a: GO:0046149 ! pigment catabolic process

[Term]
id: GO:0042168
name: heme metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:jl, ISBN:0124325653]
subset: gosubset_prok
synonym: "haem metabolic process" EXACT []
synonym: "haem metabolism" EXACT []
synonym: "heme metabolism" EXACT []
xref: Reactome:REACT_116067 "Heme metabolism, Gallus gallus"
is_a: GO:0006778 ! porphyrin-containing compound metabolic process
is_a: GO:0042440 ! pigment metabolic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0042169
name: SH2 domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class." [GOC:go_curators, Pfam:PF00017]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0042170
name: plastid membrane
namespace: cellular_component
def: "Either of the lipid bilayers that surround a plastid and form the plastid envelope." [GOC:mah]
is_a: GO:0031090 ! organelle membrane
is_a: GO:0044435 ! plastid part
relationship: part_of GO:0009526 ! plastid envelope

[Term]
id: GO:0042171
name: lysophosphatidic acid acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidic acid to form phosphatidic acid." [GOC:ab, PMID:16369050]
synonym: "LPAAT activity" EXACT [PMID:16369050]
is_a: GO:0071617 ! lysophospholipid acyltransferase activity

[Term]
id: GO:0042173
name: regulation of sporulation resulting in formation of a cellular spore
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of spore formation." [GOC:jl]
subset: gosubset_prok
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0043937 ! regulation of sporulation
is_a: GO:0045595 ! regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030435 ! sporulation resulting in formation of a cellular spore
relationship: regulates GO:0030435 ! sporulation resulting in formation of a cellular spore

[Term]
id: GO:0042174
name: negative regulation of sporulation resulting in formation of a cellular spore
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sporulation." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of sporulation" EXACT []
synonym: "down-regulation of sporulation" EXACT []
synonym: "downregulation of sporulation" EXACT []
synonym: "inhibition of sporulation" NARROW []
is_a: GO:0042173 ! regulation of sporulation resulting in formation of a cellular spore
is_a: GO:0043939 ! negative regulation of sporulation
is_a: GO:0045596 ! negative regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030435 ! sporulation resulting in formation of a cellular spore
relationship: negatively_regulates GO:0030435 ! sporulation resulting in formation of a cellular spore

[Term]
id: GO:0042175
name: nuclear outer membrane-endoplasmic reticulum membrane network
namespace: cellular_component
def: "The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane." [GOC:bf, GOC:jl, GOC:mah, GOC:mcc, GOC:pr, GOC:vw]
synonym: "NE-ER continuum" RELATED []
synonym: "NE-ER network" RELATED []
synonym: "nuclear envelope-endoplasmic reticulum continuum" RELATED []
synonym: "nuclear envelope-endoplasmic reticulum network" RELATED [GOC:mah]
synonym: "nuclear envelope-ER network" RELATED []
synonym: "nuclear membrane-endoplasmic reticulum continuum" EXACT [GOC:mah]
synonym: "nuclear membrane-ER network" EXACT [GOC:mah]
is_a: GO:0016020 ! membrane
is_a: GO:0044464 ! cell part
relationship: part_of GO:0012505 ! endomembrane system

[Term]
id: GO:0042176
name: regulation of protein catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl]
subset: gosubset_prok
synonym: "regulation of protein breakdown" EXACT []
synonym: "regulation of protein catabolism" EXACT []
synonym: "regulation of protein degradation" EXACT []
is_a: GO:0009894 ! regulation of catabolic process
is_a: GO:0051246 ! regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030163 ! protein catabolic process
relationship: regulates GO:0030163 ! protein catabolic process

[Term]
id: GO:0042177
name: negative regulation of protein catabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl, PMID:10207076]
subset: gosubset_prok
synonym: "down regulation of protein catabolic process" EXACT []
synonym: "down-regulation of protein catabolic process" EXACT []
synonym: "downregulation of protein catabolic process" EXACT []
synonym: "inhibition of protein catabolic process" NARROW []
synonym: "negative regulation of protein breakdown" EXACT []
synonym: "negative regulation of protein catabolism" EXACT []
synonym: "negative regulation of protein degradation" EXACT []
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0042176 ! regulation of protein catabolic process
is_a: GO:0051248 ! negative regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030163 ! protein catabolic process
relationship: negatively_regulates GO:0030163 ! protein catabolic process

[Term]
id: GO:0042178
name: xenobiotic catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide." [GOC:jl]
subset: gosubset_prok
synonym: "xenobiotic breakdown" EXACT []
synonym: "xenobiotic catabolism" EXACT []
synonym: "xenobiotic degradation" EXACT []
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0044248 ! cellular catabolic process

[Term]
id: GO:0042179
name: nicotine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nicotine, (S)(-)-3-(1-methyl-2-pyrrolidinyl)pyridine." [GOC:sm, ISBN:0198547684]
subset: gosubset_prok
synonym: "nicotine anabolism" EXACT []
synonym: "nicotine biosynthesis" EXACT []
synonym: "nicotine formation" EXACT []
synonym: "nicotine synthesis" EXACT []
is_a: GO:0009821 ! alkaloid biosynthetic process
is_a: GO:0018933 ! nicotine metabolic process
is_a: GO:0072525 ! pyridine-containing compound biosynthetic process

[Term]
id: GO:0042180
name: cellular ketone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:jl, ISBN:0787650153]
subset: goslim_pir
subset: gosubset_prok
synonym: "ketone metabolism" EXACT []
is_a: GO:0044237 ! cellular metabolic process
is_a: GO:0044281 ! small molecule metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0071704 ! organic substance metabolic process

[Term]
id: GO:0042181
name: ketone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:go_curators]
subset: gosubset_prok
synonym: "ketone anabolism" EXACT []
synonym: "ketone biosynthesis" EXACT []
synonym: "ketone formation" EXACT []
synonym: "ketone synthesis" EXACT []
is_a: GO:0042180 ! cellular ketone metabolic process
is_a: GO:0044249 ! cellular biosynthetic process
is_a: GO:0044283 ! small molecule biosynthetic process
is_a: GO:1901576 ! organic substance biosynthetic process

[Term]
id: GO:0042182
name: ketone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:go_curators]
subset: gosubset_prok
synonym: "ketone breakdown" EXACT []
synonym: "ketone catabolism" EXACT []
synonym: "ketone degradation" EXACT []
is_a: GO:0042180 ! cellular ketone metabolic process
is_a: GO:0044248 ! cellular catabolic process
is_a: GO:0044282 ! small molecule catabolic process
is_a: GO:1901575 ! organic substance catabolic process

[Term]
id: GO:0042183
name: formate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of formate, also known as methanoate, the anion HCOO- derived from methanoic (formic) acid." [ISBN:0198506732]
subset: gosubset_prok
synonym: "formate breakdown" EXACT []
synonym: "formate catabolism" EXACT []
synonym: "formate degradation" EXACT []
synonym: "formic acid catabolic process" EXACT []
synonym: "formic acid catabolism" EXACT []
is_a: GO:0015942 ! formate metabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0042184
name: xylene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of xylene, a mixture of three colorless, aromatic hydrocarbon liquids, ortho-, meta- and para-xylene." [GOC:go_curators]
subset: gosubset_prok
synonym: "xylene breakdown" EXACT []
synonym: "xylene catabolism" EXACT []
synonym: "xylene degradation" EXACT []
is_a: GO:0018948 ! xylene metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process

[Term]
id: GO:0042185
name: m-xylene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of m-xylene, 1,3-dimethylbenzene, a colorless, liquid aromatic hydrocarbon." [GOC:go_curators, GOC:jl]
subset: gosubset_prok
synonym: "m-xylene breakdown" EXACT []
synonym: "m-xylene catabolism" EXACT []
synonym: "m-xylene degradation" EXACT []
synonym: "meta-xylene catabolic process" EXACT []
synonym: "meta-xylene catabolism" EXACT []
xref: MetaCyc:PWY-142
is_a: GO:0018949 ! m-xylene metabolic process
is_a: GO:0042184 ! xylene catabolic process

[Term]
id: GO:0042186
name: o-xylene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of o-xylene, (1,2-dimethylbenzene) a colorless, liquid aromatic hydrocarbon." [GOC:jl]
subset: gosubset_prok
synonym: "o-xylene breakdown" EXACT []
synonym: "o-xylene catabolism" EXACT []
synonym: "o-xylene degradation" EXACT []
synonym: "ortho-xylene catabolic process" EXACT []
synonym: "ortho-xylene catabolism" EXACT []
is_a: GO:0018950 ! o-xylene metabolic process
is_a: GO:0042184 ! xylene catabolic process

[Term]
id: GO:0042187
name: p-xylene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of p-xylene (1,4-dimethylbenzene), a colorless, liquid aromatic hydrocarbon." [GOC:jl]
subset: gosubset_prok
synonym: "p-xylene breakdown" EXACT []
synonym: "p-xylene catabolism" EXACT []
synonym: "p-xylene degradation" EXACT []
synonym: "para-xylene catabolic process" EXACT []
synonym: "para-xylene catabolism" EXACT []
is_a: GO:0018951 ! p-xylene metabolic process
is_a: GO:0042184 ! xylene catabolic process

[Term]
id: GO:0042188
name: 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane (DDT), a chlorinated broad spectrum contact insecticide." [GOC:jl]
subset: gosubset_prok
synonym: "1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane breakdown" EXACT []
synonym: "1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane catabolism" EXACT []
synonym: "1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane degradation" EXACT []
synonym: "DDT catabolic process" EXACT []
synonym: "DDT catabolism" EXACT []
is_a: GO:0018977 ! 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process
is_a: GO:0046701 ! insecticide catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process

[Term]
id: GO:0042189
name: vanillin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of vanillin, an aromatic hydrocarbon which occurs naturally in black vanilla bean pods." [GOC:jl]
subset: gosubset_prok
synonym: "vanillic aldehyde biosynthesis" EXACT []
synonym: "vanillic aldehyde biosynthetic process" EXACT []
synonym: "vanillin anabolism" EXACT []
synonym: "vanillin biosynthesis" EXACT []
synonym: "vanillin formation" EXACT []
synonym: "vanillin synthesis" EXACT []
is_a: GO:0018982 ! vanillin metabolic process
is_a: GO:0046184 ! aldehyde biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:1901503 ! ether biosynthetic process

[Term]
id: GO:0042190
name: vanillin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of vanillin, an aromatic hydrocarbon which occurs naturally in black vanilla bean pods." [GOC:jl]
subset: gosubset_prok
synonym: "vanillic aldehyde catabolic process" EXACT []
synonym: "vanillic aldehyde catabolism" EXACT []
synonym: "vanillin breakdown" EXACT []
synonym: "vanillin catabolism" EXACT []
synonym: "vanillin degradation" EXACT []
is_a: GO:0018982 ! vanillin metabolic process
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0046185 ! aldehyde catabolic process
is_a: GO:1901502 ! ether catabolic process

[Term]
id: GO:0042191
name: methylmercury metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving methylmercury (MeHg+), a highly toxic organometal which can accumulate in tissues, particularly in fish species." [GOC:ai]
subset: gosubset_prok
synonym: "methylmercury metabolism" EXACT []
is_a: GO:0018941 ! organomercury metabolic process

[Term]
id: GO:0042192
name: methylmercury biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of methylmercury (MeHg+), a highly toxic organometal." [GOC:ai]
subset: gosubset_prok
synonym: "methylmercury anabolism" EXACT []
synonym: "methylmercury biosynthesis" EXACT []
synonym: "methylmercury formation" EXACT []
synonym: "methylmercury synthesis" EXACT []
is_a: GO:0042191 ! methylmercury metabolic process
is_a: GO:0046414 ! organomercury biosynthetic process

[Term]
id: GO:0042193
name: methylmercury catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of methylmercury (MeHg+), a highly toxic organometal." [GOC:ai]
subset: gosubset_prok
synonym: "methylmercury breakdown" EXACT []
synonym: "methylmercury catabolism" EXACT []
synonym: "methylmercury degradation" EXACT []
is_a: GO:0042191 ! methylmercury metabolic process
is_a: GO:0046413 ! organomercury catabolic process

[Term]
id: GO:0042194
name: quinate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of quinate, the anion of quinic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "quinate anabolism" EXACT []
synonym: "quinate biosynthesis" EXACT []
synonym: "quinate formation" EXACT []
synonym: "quinate synthesis" EXACT []
synonym: "quinic acid biosynthesis" EXACT []
synonym: "quinic acid biosynthetic process" EXACT []
is_a: GO:0019630 ! quinate metabolic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process

[Term]
id: GO:0042195
name: aerobic gallate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid, in the presence of oxygen." [GOC:jl]
subset: gosubset_prok
synonym: "aerobic gallate breakdown" EXACT []
synonym: "aerobic gallate catabolism" EXACT []
synonym: "aerobic gallate degradation" EXACT []
synonym: "aerobic gallic acid catabolic process" EXACT []
synonym: "aerobic gallic acid catabolism" EXACT []
is_a: GO:0019396 ! gallate catabolic process

[Term]
id: GO:0042196
name: chlorinated hydrocarbon metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving chlorinated hydrocarbons, any hydrocarbon with one or more chlorine atoms attached to it." [GOC:ai]
subset: gosubset_prok
synonym: "chlorinated hydrocarbon metabolism" EXACT []
is_a: GO:0042197 ! halogenated hydrocarbon metabolic process

[Term]
id: GO:0042197
name: halogenated hydrocarbon metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving halogenated hydrocarbons, any hydrocarbon with one or more halogen atoms attached to it. Halogens include fluorine, chlorine, bromine and iodine." [GOC:ai]
subset: gosubset_prok
synonym: "halogenated hydrocarbon metabolism" EXACT []
xref: Reactome:REACT_102377 "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide, Sus scrofa"
xref: Reactome:REACT_103579 "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide, Rattus norvegicus"
xref: Reactome:REACT_108924 "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide, Gallus gallus"
xref: Reactome:REACT_305 "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide, Homo sapiens"
xref: Reactome:REACT_32803 "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide, Mus musculus"
xref: Reactome:REACT_75504 "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide, Bos taurus"
xref: Reactome:REACT_77895 "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide, Taeniopygia guttata"
xref: Reactome:REACT_81599 "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide, Canis familiaris"
xref: Reactome:REACT_86609 "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide, Danio rerio"
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0044710 ! single-organism metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0071704 ! organic substance metabolic process

[Term]
id: GO:0042198
name: nylon metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nylon, a polymer where the main polymer chain comprises recurring amide groups; these compounds are generally formed from combinations of diamines, diacids and amino acids." [UniProtKB-KW:KW-0549]
subset: gosubset_prok
synonym: "nylon metabolism" EXACT []
is_a: GO:0006805 ! xenobiotic metabolic process

[Term]
id: GO:0042199
name: cyanuric acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cyanuric acid, a suspected gastrointestinal or liver toxicant, and a potential degradation product of triazine herbicides, such as atrazine and simazine. It is widely used for the stabilization of available chlorine in swimming pool water and is also the starting compound for the synthesis of many organic derivatives." [UM-BBD_pathwayID:cya]
subset: gosubset_prok
synonym: "cyanuric acid metabolism" EXACT []
is_a: GO:0018965 ! s-triazine compound metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process

[Term]
id: GO:0042200
name: cyanuric acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cyanuric acid, a potential degradation product of triazine herbicides." [UM-BBD_pathwayID:cya]
subset: gosubset_prok
synonym: "cyanuric acid breakdown" EXACT []
synonym: "cyanuric acid catabolism" EXACT []
synonym: "cyanuric acid degradation" EXACT []
xref: UM-BBD_pathwayID:cya
is_a: GO:0042199 ! cyanuric acid metabolic process
is_a: GO:0042204 ! s-triazine compound catabolic process
is_a: GO:1901616 ! organic hydroxy compound catabolic process

[Term]
id: GO:0042201
name: N-cyclopropylmelamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving N-cyclopropylmelamine, a triazine compound commonly used as an insect growth regulator insecticide." [UM-BBD_pathwayID:cpm]
subset: gosubset_prok
synonym: "cyromazine metabolic process" EXACT []
synonym: "cyromazine metabolism" EXACT []
synonym: "N-cyclopropylmelamine metabolism" EXACT []
is_a: GO:0018965 ! s-triazine compound metabolic process

[Term]
id: GO:0042202
name: N-cyclopropylmelamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of N-cyclopropylmelamine, a triazine compound commonly used as an insecticide." [UM-BBD_pathwayID:cpm]
subset: gosubset_prok
synonym: "cyromazine catabolic process" EXACT []
synonym: "cyromazine catabolism" EXACT []
synonym: "N-cyclopropylmelamine breakdown" EXACT []
synonym: "N-cyclopropylmelamine catabolism" EXACT []
synonym: "N-cyclopropylmelamine degradation" EXACT []
xref: UM-BBD_pathwayID:cpm
is_a: GO:0042201 ! N-cyclopropylmelamine metabolic process
is_a: GO:0042204 ! s-triazine compound catabolic process

[Term]
id: GO:0042203
name: toluene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products." [GOC:go_curators]
subset: gosubset_prok
synonym: "toluene breakdown" EXACT []
synonym: "toluene catabolism" EXACT []
synonym: "toluene degradation" EXACT []
is_a: GO:0018970 ! toluene metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0072491 ! toluene-containing compound catabolic process

[Term]
id: GO:0042204
name: s-triazine compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any s-triazine compound. These compounds include many pesticides of widespread use in agriculture, and are characterized by a symmetrical hexameric ring consisting of alternating carbon and nitrogen atoms." [UM-BBD_pathwayID:tria]
subset: gosubset_prok
synonym: "s-triazine compound breakdown" EXACT []
synonym: "s-triazine compound catabolism" EXACT []
synonym: "s-triazine compound degradation" EXACT []
xref: UM-BBD_pathwayID:tria
is_a: GO:0018965 ! s-triazine compound metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0044270 ! cellular nitrogen compound catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process

[Term]
id: GO:0042205
name: chlorinated hydrocarbon catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of chlorinated hydrocarbons, any hydrocarbon with one or more chlorine atoms attached to it." [GOC:ai]
subset: gosubset_prok
synonym: "chlorinated hydrocarbon breakdown" EXACT []
synonym: "chlorinated hydrocarbon catabolism" EXACT []
synonym: "chlorinated hydrocarbon degradation" EXACT []
is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process
is_a: GO:0042206 ! halogenated hydrocarbon catabolic process

[Term]
id: GO:0042206
name: halogenated hydrocarbon catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of halogenated hydrocarbons, any hydrocarbon with one or more halogen atoms attached to it." [GOC:ai]
subset: gosubset_prok
synonym: "halogenated hydrocarbon breakdown" EXACT []
synonym: "halogenated hydrocarbon catabolism" EXACT []
synonym: "halogenated hydrocarbon degradation" EXACT []
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0042197 ! halogenated hydrocarbon metabolic process
is_a: GO:0044712 ! single-organism catabolic process
is_a: GO:1901575 ! organic substance catabolic process

[Term]
id: GO:0042207
name: styrene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of styrene, an aromatic hydrocarbon liquid used in the manufacture of polystyrene." [GOC:jl]
subset: gosubset_prok
synonym: "styrene breakdown" EXACT []
synonym: "styrene catabolism" EXACT []
synonym: "styrene degradation" EXACT []
xref: UM-BBD_pathwayID:sty
is_a: GO:0018966 ! styrene metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process

[Term]
id: GO:0042208
name: propylene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of propylene, an alkene produced by catalytic or thermal cracking of hydrocarbons or as a by-product of petroleum refining." [GOC:jl]
subset: gosubset_prok
synonym: "propylene breakdown" EXACT []
synonym: "propylene catabolism" EXACT []
synonym: "propylene degradation" EXACT []
xref: UM-BBD_pathwayID:pro
is_a: GO:0018964 ! propylene metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0043451 ! alkene catabolic process

[Term]
id: GO:0042209
name: orcinol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of orcinol (5-methyl-1,3-benzenediol), an aromatic compound derived from the fermentation of lichen and synthesized by some higher plants." [GOC:jl]
subset: gosubset_prok
synonym: "orcin catabolic process" EXACT []
synonym: "orcin catabolism" EXACT []
synonym: "orcinol breakdown" EXACT []
synonym: "orcinol catabolism" EXACT []
synonym: "orcinol degradation" EXACT []
xref: UM-BBD_pathwayID:orc
is_a: GO:0018940 ! orcinol metabolic process
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0072491 ! toluene-containing compound catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process

[Term]
id: GO:0042210
name: octamethylcyclotetrasiloxane catabolic process to dimethylsilanediol
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of octamethylcyclotetrasiloxane into dimethylsilanediol. The former is a tetramer of the latter." [GOC:jl]
subset: gosubset_prok
synonym: "catabolic process of octamethylcyclotetrasiloxane to DMSD" EXACT []
synonym: "catabolism of octamethylcyclotetrasiloxane to DMSD" EXACT []
synonym: "octamethylcyclotetrasiloxane breakdown to dimethylsilanediol" EXACT []
synonym: "octamethylcyclotetrasiloxane degradation to dimethylsilanediol" EXACT []
xref: UM-BBD_pathwayID:osi
is_a: GO:0018947 ! anaerobic organosilicon metabolic process
is_a: GO:0044712 ! single-organism catabolic process
is_a: GO:0046454 ! dimethylsilanediol metabolic process
is_a: GO:0046517 ! octamethylcyclotetrasiloxane catabolic process

[Term]
id: GO:0042211
name: dimethylsilanediol catabolic process
namespace: biological_process
def: "The aerobic chemical reactions and pathways resulting in the breakdown of dimethylsilanediol, the smallest member of the dialkylsilanediols. Dimethylsilanediol is the monomer of polydimethylsiloxane, a compound which can be found in a wide range of industrial and consumer products." [GOC:jl]
subset: gosubset_prok
synonym: "catabolic process of DMSD" EXACT []
synonym: "catabolism of DMSD" EXACT []
synonym: "degradation of dimethylsilanediol" EXACT []
synonym: "dimethylsilanediol breakdown" EXACT []
synonym: "dimethylsilanediol catabolism" EXACT []
synonym: "dimethylsilanediol degradation" EXACT []
is_a: GO:0018946 ! aerobic organosilicon metabolic process
is_a: GO:0044712 ! single-organism catabolic process
is_a: GO:0046454 ! dimethylsilanediol metabolic process
is_a: GO:0046455 ! organosilicon catabolic process

[Term]
id: GO:0042212
name: cresol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cresol, a mixture of the aromatic alcohol isoforms o-, p-, and m-cresol, which is obtained from coal tar or petroleum. The isomers are used as disinfectants, textile scouring agents, surfactants and as intermediates in the manufacture of salicylaldehyde, coumarin, and herbicides as well as being a major component of creosote." [UM-BBD_pathwayID:mcr]
subset: gosubset_prok
synonym: "cresol metabolism" EXACT []
synonym: "hydroxytoluene metabolic process" EXACT []
synonym: "hydroxytoluene metabolism" EXACT []
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0072490 ! toluene-containing compound metabolic process

[Term]
id: GO:0042213
name: m-cresol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of m-cresol (3-hydroxytoluene), the meta-isoform of cresol." [GOC:jl]
subset: gosubset_prok
synonym: "3-hydroxytoluene catabolic process" EXACT []
synonym: "3-hydroxytoluene catabolism" EXACT []
synonym: "m-cresol breakdown" EXACT []
synonym: "m-cresol catabolism" EXACT []
synonym: "m-cresol degradation" EXACT []
synonym: "meta-cresol catabolic process" EXACT []
synonym: "meta-cresol catabolism" EXACT []
xref: MetaCyc:M-CRESOL-DEGRADATION-PWY
xref: UM-BBD_pathwayID:mcr
is_a: GO:0018925 ! m-cresol metabolic process
is_a: GO:0046199 ! cresol catabolic process

[Term]
id: GO:0042214
name: terpene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving terpenes, any of a large group of hydrocarbons that are made up of isoprene (C5H8) units which may be cyclic, acyclic or multicyclic, saturated or unsaturated, and may contain various functional groups." [CHEBI:35186, GOC:curators]
subset: gosubset_prok
synonym: "terpene metabolism" EXACT []
is_a: GO:0006720 ! isoprenoid metabolic process

[Term]
id: GO:0042215
name: anaerobic phenol-containing compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the absence of oxygen." [CHEBI:33853, ISBN:0198506732]
subset: gosubset_prok
synonym: "anaerobic phenol-containing compound metabolism" EXACT [GOC:curators]
xref: UM-BBD_pathwayID:phe
is_a: GO:0018958 ! phenol-containing compound metabolic process

[Term]
id: GO:0042216
name: phenanthrene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phenanthrene, a tricyclic aromatic hydrocarbon." [GOC:jl]
subset: gosubset_prok
synonym: "phenanthrene breakdown" EXACT []
synonym: "phenanthrene catabolism" EXACT []
synonym: "phenanthrene degradation" EXACT []
xref: UM-BBD_pathwayID:phe
is_a: GO:0018955 ! phenanthrene metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process

[Term]
id: GO:0042217
name: 1-aminocyclopropane-1-carboxylate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 1-aminocyclopropane-1-carboxylate, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants." [GOC:go_curators]
subset: gosubset_prok
synonym: "1-aminocyclopropane-1-carboxylate breakdown" EXACT []
synonym: "1-aminocyclopropane-1-carboxylate catabolism" EXACT []
synonym: "1-aminocyclopropane-1-carboxylate degradation" EXACT []
is_a: GO:0018871 ! 1-aminocyclopropane-1-carboxylate metabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:1901606 ! alpha-amino acid catabolic process

[Term]
id: GO:0042218
name: 1-aminocyclopropane-1-carboxylate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 1-aminocyclopropane-1-carboxylate, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants." [GOC:go_curators]
subset: gosubset_prok
synonym: "1-aminocyclopropane-1-carboxylate anabolism" EXACT []
synonym: "1-aminocyclopropane-1-carboxylate biosynthesis" EXACT []
synonym: "1-aminocyclopropane-1-carboxylate formation" EXACT []
synonym: "1-aminocyclopropane-1-carboxylate synthesis" EXACT []
is_a: GO:0018871 ! 1-aminocyclopropane-1-carboxylate metabolic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:1901607 ! alpha-amino acid biosynthetic process

[Term]
id: GO:0042219
name: cellular modified amino acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai]
subset: gosubset_prok
synonym: "amino acid derivative catabolic process" EXACT [GOC:curators]
synonym: "cellular amino acid derivative breakdown" EXACT []
synonym: "cellular amino acid derivative catabolic process" EXACT [GOC:curators]
synonym: "cellular amino acid derivative catabolism" EXACT []
synonym: "cellular amino acid derivative degradation" EXACT []
synonym: "cellular modified amino acid breakdown" EXACT [GOC:mah]
synonym: "cellular modified amino acid catabolism" EXACT [GOC:mah]
synonym: "cellular modified amino acid degradation" EXACT [GOC:mah]
synonym: "modified amino acid catabolic process" EXACT [GOC:mah]
synonym: "modified amino acid catabolism" EXACT [GOC:mah]
is_a: GO:0006575 ! cellular modified amino acid metabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process

[Term]
id: GO:0042220
name: response to cocaine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant." [CHEBI:27958, GOC:ef, GOC:jl]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0043279 ! response to alkaloid
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0042221
name: response to chemical
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_yeast
subset: gosubset_prok
synonym: "response to chemical stimulus" EXACT [GOC:dos]
synonym: "response to chemical substance" EXACT []
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0042222
name: interleukin-1 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-1, an interleukin produced mainly by activated macrophages. It is involved in the inflammatory response, and is identified as an endogenous pyrogen." [GOC:jl, ISBN:0198506732]
synonym: "IL-1 biosynthesis" EXACT []
synonym: "IL-1 biosynthetic process" EXACT []
synonym: "interleukin-1 anabolism" EXACT []
synonym: "interleukin-1 biosynthesis" EXACT []
synonym: "interleukin-1 formation" EXACT []
synonym: "interleukin-1 synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032612 ! interleukin-1 production

[Term]
id: GO:0042223
name: interleukin-3 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-3." [GOC:go_curators]
synonym: "IL-3 biosynthesis" EXACT []
synonym: "IL-3 biosynthetic process" EXACT []
synonym: "interleukin-3 anabolism" EXACT []
synonym: "interleukin-3 biosynthesis" EXACT []
synonym: "interleukin-3 formation" EXACT []
synonym: "interleukin-3 synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032632 ! interleukin-3 production

[Term]
id: GO:0042225
name: interleukin-5 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-5." [GOC:go_curators]
synonym: "IL-5 biosynthesis" EXACT []
synonym: "IL-5 biosynthetic process" EXACT []
synonym: "interleukin-5 anabolism" EXACT []
synonym: "interleukin-5 biosynthesis" EXACT []
synonym: "interleukin-5 formation" EXACT []
synonym: "interleukin-5 synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032634 ! interleukin-5 production

[Term]
id: GO:0042226
name: interleukin-6 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-6." [GOC:go_curators]
synonym: "IL-6 biosynthesis" EXACT []
synonym: "IL-6 biosynthetic process" EXACT []
synonym: "interleukin-6 anabolism" EXACT []
synonym: "interleukin-6 biosynthesis" EXACT []
synonym: "interleukin-6 formation" EXACT []
synonym: "interleukin-6 synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032635 ! interleukin-6 production

[Term]
id: GO:0042227
name: interleukin-7 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-7." [GOC:go_curators]
synonym: "IL-7 biosynthesis" EXACT []
synonym: "IL-7 biosynthetic process" EXACT []
synonym: "interleukin-7 anabolism" EXACT []
synonym: "interleukin-7 biosynthesis" EXACT []
synonym: "interleukin-7 formation" EXACT []
synonym: "interleukin-7 synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032636 ! interleukin-7 production

[Term]
id: GO:0042228
name: interleukin-8 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-8." [GOC:go_curators]
synonym: "IL-8 biosynthesis" EXACT []
synonym: "IL-8 biosynthetic process" EXACT []
synonym: "interleukin-8 anabolism" EXACT []
synonym: "interleukin-8 biosynthesis" EXACT []
synonym: "interleukin-8 formation" EXACT []
synonym: "interleukin-8 synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032637 ! interleukin-8 production

[Term]
id: GO:0042229
name: interleukin-9 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-9." [GOC:go_curators]
synonym: "IL-9 biosynthesis" EXACT []
synonym: "IL-9 biosynthetic process" EXACT []
synonym: "interleukin-9 anabolism" EXACT []
synonym: "interleukin-9 biosynthesis" EXACT []
synonym: "interleukin-9 formation" EXACT []
synonym: "interleukin-9 synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032638 ! interleukin-9 production

[Term]
id: GO:0042230
name: interleukin-11 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-11." [GOC:go_curators]
synonym: "IL-11 biosynthesis" EXACT []
synonym: "IL-11 biosynthetic process" EXACT []
synonym: "interleukin-11 anabolism" EXACT []
synonym: "interleukin-11 biosynthesis" EXACT []
synonym: "interleukin-11 formation" EXACT []
synonym: "interleukin-11 synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032614 ! interleukin-11 production

[Term]
id: GO:0042231
name: interleukin-13 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-13." [GOC:go_curators]
synonym: "IL-13 biosynthesis" EXACT []
synonym: "IL-13 biosynthetic process" EXACT []
synonym: "interleukin-13 anabolism" EXACT []
synonym: "interleukin-13 biosynthesis" EXACT []
synonym: "interleukin-13 formation" EXACT []
synonym: "interleukin-13 synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032616 ! interleukin-13 production

[Term]
id: GO:0042232
name: interleukin-14 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-14." [GOC:go_curators]
synonym: "IL-14 biosynthesis" EXACT []
synonym: "IL-14 biosynthetic process" EXACT []
synonym: "interleukin-14 anabolism" EXACT []
synonym: "interleukin-14 biosynthesis" EXACT []
synonym: "interleukin-14 formation" EXACT []
synonym: "interleukin-14 synthesis" EXACT []
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032617 ! interleukin-14 production

[Term]
id: GO:0042233
name: interleukin-15 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-15." [GOC:go_curators]
synonym: "IL-15 biosynthesis" EXACT []
synonym: "IL-15 biosynthetic process" EXACT []
synonym: "interleukin-15 anabolism" EXACT []
synonym: "interleukin-15 biosynthesis" EXACT []
synonym: "interleukin-15 formation" EXACT []
synonym: "interleukin-15 synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032618 ! interleukin-15 production

[Term]
id: GO:0042234
name: interleukin-16 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-16." [GOC:go_curators]
synonym: "IL-16 biosynthesis" EXACT []
synonym: "IL-16 biosynthetic process" EXACT []
synonym: "interleukin-16 anabolism" EXACT []
synonym: "interleukin-16 biosynthesis" EXACT []
synonym: "interleukin-16 formation" EXACT []
synonym: "interleukin-16 synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032619 ! interleukin-16 production

[Term]
id: GO:0042235
name: interleukin-17 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any member of the interleukin-17 family of cytokines." [GOC:add, GOC:go_curators]
synonym: "IL-17 biosynthesis" EXACT []
synonym: "IL-17 biosynthetic process" EXACT []
synonym: "interleukin-17 anabolism" EXACT []
synonym: "interleukin-17 biosynthesis" EXACT []
synonym: "interleukin-17 formation" EXACT []
synonym: "interleukin-17 synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032620 ! interleukin-17 production

[Term]
id: GO:0042236
name: interleukin-19 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-19." [GOC:go_curators]
synonym: "IL-19 biosynthesis" EXACT []
synonym: "IL-19 biosynthetic process" EXACT []
synonym: "interleukin-19 anabolism" EXACT []
synonym: "interleukin-19 biosynthesis" EXACT []
synonym: "interleukin-19 formation" EXACT []
synonym: "interleukin-19 synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032622 ! interleukin-19 production

[Term]
id: GO:0042237
name: interleukin-20 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-20." [GOC:go_curators]
synonym: "IL-20 biosynthesis" EXACT []
synonym: "IL-20 biosynthetic process" EXACT []
synonym: "interleukin-20 anabolism" EXACT []
synonym: "interleukin-20 biosynthesis" EXACT []
synonym: "interleukin-20 formation" EXACT []
synonym: "interleukin-20 synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032624 ! interleukin-20 production

[Term]
id: GO:0042238
name: interleukin-21 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-21." [GOC:go_curators]
synonym: "IL-21 biosynthesis" EXACT []
synonym: "IL-21 biosynthetic process" EXACT []
synonym: "interleukin-21 anabolism" EXACT []
synonym: "interleukin-21 biosynthesis" EXACT []
synonym: "interleukin-21 formation" EXACT []
synonym: "interleukin-21 synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032625 ! interleukin-21 production

[Term]
id: GO:0042239
name: interleukin-22 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-22." [GOC:go_curators]
synonym: "IL-22 biosynthesis" EXACT []
synonym: "IL-22 biosynthetic process" EXACT []
synonym: "interleukin-22 anabolism" EXACT []
synonym: "interleukin-22 biosynthesis" EXACT []
synonym: "interleukin-22 formation" EXACT []
synonym: "interleukin-22 synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032626 ! interleukin-22 production

[Term]
id: GO:0042240
name: interleukin-23 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-23." [GOC:go_curators]
synonym: "IL-23 biosynthesis" EXACT []
synonym: "IL-23 biosynthetic process" EXACT []
synonym: "interleukin-23 anabolism" EXACT []
synonym: "interleukin-23 biosynthesis" EXACT []
synonym: "interleukin-23 formation" EXACT []
synonym: "interleukin-23 synthesis" EXACT []
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032627 ! interleukin-23 production

[Term]
id: GO:0042241
name: interleukin-18 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-18." [GOC:go_curators]
synonym: "IL-18 biosynthesis" EXACT []
synonym: "IL-18 biosynthetic process" EXACT []
synonym: "interleukin-18 anabolism" EXACT []
synonym: "interleukin-18 biosynthesis" EXACT []
synonym: "interleukin-18 formation" EXACT []
synonym: "interleukin-18 synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032621 ! interleukin-18 production

[Term]
id: GO:0042242
name: cobyrinic acid a,c-diamide synthase activity
namespace: molecular_function
def: "Catalysis of the conversion of cobyrinic acid to cobyrinic acid a,c-diamide via the intermediate formation of cobyrinic acid c-monoamide." [PMID:2172209]
comment: Note that this enzyme does not have an EC number yet, as its activity has not been proven experimentally. May need to be moved in the future.
subset: gosubset_prok
subset: mf_needs_review
synonym: "CobB" NARROW []
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0042243
name: asexual spore wall assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an asexual spore wall, the specialized envelope lying outside the cell membrane of a spore derived from an asexual process. Examples of this process are found in Bacterial and Fungal species." [GOC:mah]
subset: gosubset_prok
synonym: "asexual spore wall formation" EXACT []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0042244 ! spore wall assembly
is_a: GO:0044702 ! single organism reproductive process
relationship: part_of GO:0030436 ! asexual sporulation

[Term]
id: GO:0042244
name: spore wall assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a spore wall; a spore wall is the specialized envelope lying outside the cell membrane of a spore." [GOC:mah, GOC:pg]
subset: gosubset_prok
synonym: "spore coat biosynthesis" EXACT []
synonym: "spore coat biosynthetic process" EXACT []
synonym: "spore wall formation" EXACT []
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
is_a: GO:0070726 ! cell wall assembly
relationship: part_of GO:0070590 ! spore wall biogenesis

[Term]
id: GO:0042245
name: RNA repair
namespace: biological_process
def: "Any process that results in the repair of damaged RNA." [PMID:11000254, PMID:11070075, UniProtKB-KW:KW-0692]
subset: gosubset_prok
is_a: GO:0016070 ! RNA metabolic process

[Term]
id: GO:0042246
name: tissue regeneration
namespace: biological_process
def: "The regrowth of lost or destroyed tissues." [GOC:curators]
is_a: GO:0009888 ! tissue development
is_a: GO:0031099 ! regeneration
is_a: GO:0048589 ! developmental growth
relationship: part_of GO:0042060 ! wound healing

[Term]
id: GO:0042247
name: establishment of planar polarity of follicular epithelium
namespace: biological_process
def: "Coordinated organization of groups of cells in the plane of a follicular epithelium, such that they all orient to similar coordinates." [GOC:ascb_2009, GOC:bf, GOC:dph, GOC:tb]
is_a: GO:0001736 ! establishment of planar polarity
is_a: GO:0016334 ! establishment or maintenance of polarity of follicular epithelium

[Term]
id: GO:0042248
name: maintenance of polarity of follicular epithelium
namespace: biological_process
def: "The maintenance of an established polarized follicular epithelial sheet." [GOC:bf]
is_a: GO:0016334 ! establishment or maintenance of polarity of follicular epithelium

[Term]
id: GO:0042249
name: establishment of planar polarity of embryonic epithelium
namespace: biological_process
def: "Coordinated organization of groups of cells in the plane of an embryonic epithelium, such that they all orient to similar coordinates." [GOC:ascb_2009, GOC:dph, GOC:jl, GOC:tb]
is_a: GO:0001736 ! establishment of planar polarity

[Term]
id: GO:0042250
name: maintenance of polarity of embryonic epithelium
namespace: biological_process
def: "The maintenance of an established polarized embryonic epithelial sheet." [GOC:jl]
is_a: GO:0016332 ! establishment or maintenance of polarity of embryonic epithelium

[Term]
id: GO:0042251
name: maintenance of polarity of larval imaginal disc epithelium
namespace: biological_process
def: "The maintenance of an established polarized larval imaginal disc epithelium." [GOC:jl]
is_a: GO:0016336 ! establishment or maintenance of polarity of larval imaginal disc epithelium

[Term]
id: GO:0042252
name: establishment of planar polarity of larval imaginal disc epithelium
namespace: biological_process
def: "Coordinated organization of groups of cells in the plane of a larval imaginal disc epithelium, such that they all orient to similar coordinates." [GOC:jl]
is_a: GO:0001736 ! establishment of planar polarity

[Term]
id: GO:0042253
name: granulocyte macrophage colony-stimulating factor biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of granulocyte macrophage colony-stimulating factor, cytokines that act in hemopoiesis by controlling the production, differentiation, and function of two related white cell populations, granulocytes and monocytes-macrophages." [GOC:jl, ISBN:0198506732]
synonym: "GM-CSF biosynthesis" EXACT []
synonym: "GM-CSF biosynthetic process" EXACT []
synonym: "GMC-SF biosynthesis" EXACT []
synonym: "GMC-SF biosynthetic process" EXACT []
synonym: "granulocyte macrophage colony stimulating factor biosynthetic process" EXACT []
synonym: "granulocyte macrophage colony-stimulating factor anabolism" EXACT []
synonym: "granulocyte macrophage colony-stimulating factor biosynthesis" EXACT []
synonym: "granulocyte macrophage colony-stimulating factor formation" EXACT []
synonym: "granulocyte macrophage colony-stimulating factor synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032604 ! granulocyte macrophage colony-stimulating factor production

[Term]
id: GO:0042254
name: ribosome biogenesis
namespace: biological_process
alt_id: GO:0007046
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma]
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_pir
subset: goslim_pombe
subset: gosubset_prok
synonym: "ribosomal chaperone activity" RELATED []
synonym: "ribosome biogenesis and assembly" EXACT []
xref: Wikipedia:Ribosome_biogenesis
is_a: GO:0022613 ! ribonucleoprotein complex biogenesis

[Term]
id: GO:0042255
name: ribosome assembly
namespace: biological_process
alt_id: GO:0042257
def: "The aggregation, arrangement and bonding together of the mature ribosome and of its subunits." [GOC:ma]
subset: goslim_yeast
subset: gosubset_prok
synonym: "ribosomal subunit assembly" NARROW [GOC:mah, GOC:vw]
is_a: GO:0022618 ! ribonucleoprotein complex assembly
is_a: GO:0070925 ! organelle assembly
relationship: part_of GO:0042254 ! ribosome biogenesis

[Term]
id: GO:0042256
name: mature ribosome assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of the large and small ribosomal subunits into a functional ribosome." [GOC:ma]
subset: gosubset_prok
is_a: GO:0042255 ! ribosome assembly

[Term]
id: GO:0042258
name: molybdenum incorporation via L-serinyl molybdopterin guanine dinucleotide
namespace: biological_process
def: "The incorporation of molybdenum into a protein via L-serinyl molybdopterin guanine dinucleotide." [PDB:1EU1, PMID:8658132, RESID:AA0319]
subset: gosubset_prok
xref: RESID:AA0319
is_a: GO:0018209 ! peptidyl-serine modification
is_a: GO:0018315 ! molybdenum incorporation into molybdenum-molybdopterin complex

[Term]
id: GO:0042259
name: peptidyl-L-beta-methylthioasparagine biosynthetic process from peptidyl-asparagine
namespace: biological_process
def: "The modification of peptidyl-asparagine to form peptidyl-L-beta-methylthioasparagine, typical of bacterial ribosomal protein S12." [GOC:jsg, RESID:AA0320]
subset: gosubset_prok
synonym: "peptidyl-L-beta-methylthioasparagine anabolism from peptidyl-asparagine" EXACT []
synonym: "peptidyl-L-beta-methylthioasparagine formation from peptidyl-asparagine" EXACT []
synonym: "peptidyl-L-beta-methylthioasparagine synthesis from peptidyl-asparagine" EXACT []
xref: RESID:AA0320
is_a: GO:0018196 ! peptidyl-asparagine modification

[Term]
id: GO:0042262
name: DNA protection
namespace: biological_process
def: "Any process in which DNA is protected from damage by, for example, oxidative stress." [GOC:jl]
subset: gosubset_prok
is_a: GO:0006259 ! DNA metabolic process
is_a: GO:0031668 ! cellular response to extracellular stimulus
is_a: GO:0033554 ! cellular response to stress
is_a: GO:0044710 ! single-organism metabolic process

[Term]
id: GO:0042263
name: neuropeptide F receptor activity
namespace: molecular_function
def: "Combining with neuropeptide F and transmitting the signal within the cell to initiate a change in cell activity. Neuropeptide F is an arthropod peptide of more than 28 residues (typically 28-45) with a consensus C-terminal RxRFamide (commonly RPRFa, but also RVRFa." [GOC:bf, GOC:ma, PMID:21440021]
comment: Despite their naming, neuropeptide F (NPF) and short neuropeptide F (sNPF) are not closely related.
synonym: "NPF receptor activity" EXACT [PMID:21440021]
is_a: GO:0008188 ! neuropeptide receptor activity

[Term]
id: GO:0042264
name: peptidyl-aspartic acid hydroxylation
namespace: biological_process
def: "The hydroxylation of peptidyl-aspartic acid to form peptidyl-hydroxyaspartic acid." [GOC:mah]
subset: gosubset_prok
synonym: "peptidyl-aspartic acid/asparagine hydroxylation" BROAD []
is_a: GO:0018126 ! protein hydroxylation
is_a: GO:0018197 ! peptidyl-aspartic acid modification

[Term]
id: GO:0042265
name: peptidyl-asparagine hydroxylation
namespace: biological_process
def: "The hydroxylation of peptidyl-asparagine to form peptidyl-hydroxyasparagine." [GOC:mah]
subset: gosubset_prok
synonym: "peptidyl-aspartic acid/asparagine hydroxylation" BROAD []
is_a: GO:0018126 ! protein hydroxylation
is_a: GO:0018196 ! peptidyl-asparagine modification

[Term]
id: GO:0042267
name: natural killer cell mediated cytotoxicity
namespace: biological_process
def: "The directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors." [GOC:add, GOC:pr]
comment: Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell.
synonym: "killer activity" RELATED []
synonym: "natural killer cell mediated cell death" EXACT []
synonym: "natural killer cell mediated cell killing" EXACT []
synonym: "natural killer cell mediated cytolysis" RELATED []
synonym: "natural killer-cell mediated cytolysis" RELATED []
synonym: "NK cell mediated cell death" EXACT []
synonym: "NK cell mediated cell killing" EXACT []
synonym: "NK cell mediated cytolysis" RELATED []
synonym: "NK cell mediated cytotoxicity" EXACT []
is_a: GO:0001909 ! leukocyte mediated cytotoxicity
is_a: GO:0002228 ! natural killer cell mediated immunity
is_a: GO:0044699 ! single-organism process

[Term]
id: GO:0042268
name: regulation of cytolysis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the rupture of cell membranes and the loss of cytoplasm." [GOC:jl, GOC:mtg_apoptosis]
subset: gosubset_prok
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019835 ! cytolysis
relationship: regulates GO:0019835 ! cytolysis

[Term]
id: GO:0042269
name: regulation of natural killer cell mediated cytotoxicity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of natural killer cell mediated cytotoxicity." [GOC:add, ISBN:0781735149]
synonym: "regulation of natural killer cell mediated cell death" EXACT []
synonym: "regulation of natural killer cell mediated cell killing" EXACT []
synonym: "regulation of natural killer cell mediated cytolysis" RELATED []
synonym: "regulation of natural killer-cell mediated cytolysis" RELATED []
synonym: "regulation of NK cell mediated cell death" EXACT []
synonym: "regulation of NK cell mediated cell killing" EXACT []
synonym: "regulation of NK cell mediated cytolysis" RELATED []
synonym: "regulation of NK cell mediated cytotoxicity" RELATED []
is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity
is_a: GO:0002715 ! regulation of natural killer cell mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042267 ! natural killer cell mediated cytotoxicity
relationship: regulates GO:0042267 ! natural killer cell mediated cytotoxicity

[Term]
id: GO:0042270
name: protection from natural killer cell mediated cytotoxicity
namespace: biological_process
def: "The process of protecting a cell from natural killer cell mediated cytotoxicity." [GOC:add, ISBN:0781735149]
synonym: "protection from natural killer cell mediated cell death" EXACT []
synonym: "protection from natural killer cell mediated cell killing" EXACT []
synonym: "protection from natural killer cell mediated cytolysis" RELATED []
synonym: "protection from NK cell mediated cell death" EXACT []
synonym: "protection from NK cell mediated cell killing" EXACT []
synonym: "protection from NK cell mediated cytolysis" RELATED []
synonym: "protection from NK cell mediated cytotoxicity" EXACT []
is_a: GO:0045953 ! negative regulation of natural killer cell mediated cytotoxicity

[Term]
id: GO:0042271
name: susceptibility to natural killer cell mediated cytotoxicity
namespace: biological_process
def: "The process of causing a cell to become susceptible to natural killer cell mediated cytotoxicity." [GOC:add, ISBN:0781735149]
comment: Note that this term is intended for cell-surface molecules on a target cell which interact with activating receptors on a natural killer cell to promote natural killer cell mediated cytotoxicity.
synonym: "susceptibility to natural killer cell mediated cell death" EXACT []
synonym: "susceptibility to natural killer cell mediated cell killing" EXACT []
synonym: "susceptibility to natural killer cell mediated cytolysis" RELATED []
synonym: "susceptibility to NK cell mediated cell death" EXACT []
synonym: "susceptibility to NK cell mediated cell killing" EXACT []
synonym: "susceptibility to NK cell mediated cytolysis" EXACT []
synonym: "susceptibility to NK cell mediated cytotoxicity" EXACT []
is_a: GO:0045954 ! positive regulation of natural killer cell mediated cytotoxicity

[Term]
id: GO:0042272
name: nuclear RNA export factor complex
namespace: cellular_component
def: "A protein complex that contains two proteins (know in several organisms, including Drosophila, as NXF1 and NXF2) and is required for the export of the majority of mRNAs from the nucleus to the cytoplasm; localized in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex; shuttles between the nucleus and the cytoplasm." [PMID:11780633]
synonym: "Mex67-Mtr2 complex" EXACT []
synonym: "NXF1-NXT1 complex" EXACT []
synonym: "TAP-p15 complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part

[Term]
id: GO:0042273
name: ribosomal large subunit biogenesis
namespace: biological_process
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]
subset: goslim_yeast
synonym: "ribosomal large subunit biogenesis and assembly" EXACT []
is_a: GO:0022613 ! ribonucleoprotein complex biogenesis
relationship: part_of GO:0042254 ! ribosome biogenesis

[Term]
id: GO:0042274
name: ribosomal small subunit biogenesis
namespace: biological_process
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]
subset: goslim_yeast
synonym: "ribosomal small subunit biogenesis and assembly" EXACT []
is_a: GO:0022613 ! ribonucleoprotein complex biogenesis
relationship: part_of GO:0042254 ! ribosome biogenesis

[Term]
id: GO:0042275
name: error-free postreplication DNA repair
namespace: biological_process
def: "The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA via processes such as template switching, which does not remove the replication-blocking lesions but does not increase the endogenous mutation rate." [GOC:elh, GOC:jl, PMID:11459630]
comment: Note that 'error-free' does not mean that literally zero errors occur during DNA synthesis, but that the error rate is low, comparable to that of DNA synthesis during replication.
subset: gosubset_prok
synonym: "error-free PRR" EXACT []
synonym: "error-free replication restart" RELATED []
is_a: GO:0006301 ! postreplication repair

[Term]
id: GO:0042276
name: error-prone translesion synthesis
namespace: biological_process
def: "The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites." [GOC:elh, GOC:jl, PMID:11485998]
subset: gosubset_prok
synonym: "error-prone postreplication DNA repair" RELATED [GOC:elh]
synonym: "mutagenic postreplication DNA repair" RELATED [GOC:elh]
synonym: "mutagenic PRR" EXACT []
is_a: GO:0019985 ! translesion synthesis

[Term]
id: GO:0042277
name: peptide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with peptides, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds." [GOC:jl]
subset: goslim_chembl
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0033218 ! amide binding

[Term]
id: GO:0042278
name: purine nucleoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:jl, ISBN:0140512713]
subset: gosubset_prok
synonym: "purine metabolic process" BROAD []
synonym: "purine metabolism" BROAD []
synonym: "purine nucleoside metabolism" EXACT []
is_a: GO:0009116 ! nucleoside metabolic process
is_a: GO:0072521 ! purine-containing compound metabolic process

[Term]
id: GO:0042279
name: nitrite reductase (cytochrome, ammonia-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: NH3 + 2 H2O + 6 ferricytochrome c = nitrite + 6 ferrocytochrome c + 7 H+." [EC:1.7.2.2]
subset: gosubset_prok
synonym: "ammonia:ferricytochrome-c oxidoreductase activity" EXACT [EC:1.7.2.2]
synonym: "cytochrome c nitrite reductase activity" EXACT []
synonym: "cytochrome c552 activity" NARROW [EC:1.7.2.2]
synonym: "multiheme nitrite reductase activity" EXACT []
synonym: "nitrite reductase (cytochrome; ammonia-forming)" EXACT [EC:1.7.2.2]
xref: EC:1.7.2.2
xref: MetaCyc:1.7.2.2-RXN
xref: Wikipedia:Nitrite_reductase_(cytochrome;_ammonia-forming)
is_a: GO:0016662 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor
is_a: GO:0098809 ! nitrite reductase activity

[Term]
id: GO:0042280
name: obsolete cell surface antigen activity, host-interacting
namespace: molecular_function
def: "OBSOLETE. Functions as an immunogenic target for the host immune system that masks other invariant surface molecules from immune recognition." [GOC:mb]
comment: This term was made obsolete because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity.
synonym: "cell surface antigen activity, host-interacting" EXACT []
is_obsolete: true
consider: GO:0044403
consider: GO:0046789

[Term]
id: GO:0042281
name: dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the addition of the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol." [GOC:al, MetaCyc:RXN-5470]
synonym: "dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase activity" EXACT []
xref: EC:2.4.1.-
xref: MetaCyc:RXN-5470
is_a: GO:0046527 ! glucosyltransferase activity
relationship: part_of GO:0006490 ! oligosaccharide-lipid intermediate biosynthetic process

[Term]
id: GO:0042282
name: hydroxymethylglutaryl-CoA reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-mevalonate + CoA + 2 NAD(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADH." [EC:1.1.1.88, RHEA:14836]
subset: gosubset_prok
synonym: "(R)-mevalonate:NAD+ oxidoreductase (CoA-acylating)" EXACT [EC:1.1.1.88]
synonym: "3-hydroxy-3-methylglutaryl coenzyme A reductase activity" EXACT [EC:1.1.1.88]
synonym: "3-hydroxy-3-methylglutaryl-coenzyme A reductase activity" BROAD [EC:1.1.1.88]
synonym: "beta-hydroxy-beta-methylglutaryl CoA-reductase activity" BROAD [EC:1.1.1.88]
synonym: "beta-hydroxy-beta-methylglutaryl coenzyme A reductase activity" BROAD [EC:1.1.1.88]
synonym: "HMG-CoA reductase activity" BROAD [EC:1.1.1.88]
synonym: "hydroxymethylglutaryl coenzyme A reductase activity" BROAD [EC:1.1.1.88]
synonym: "hydroxymethylglutaryl-CoA reductase (NADH) activity" EXACT [EC:1.1.1.88]
xref: EC:1.1.1.88
xref: KEGG:R02081
xref: MetaCyc:HYDROXYMETHYLGLUTARYL-COA-REDUCTASE-RXN
xref: RHEA:14836
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0042283
name: dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the addition of the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol." [MetaCyc:RXN-5471, PMID:12480927]
synonym: "dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase activity" EXACT []
xref: EC:2.4.1.-
xref: MetaCyc:RXN-5471
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0042284
name: sphingolipid delta-4 desaturase activity
namespace: molecular_function
def: "Catalysis of the introduction of a trans double bond between C4 and C5 of the long chain base region of a sphingolipid. Sphingolipids are composed of a long chain base (LCB) amide-linked to a very long chain fatty acid." [PMID:12417141]
synonym: "delta-4 sphingolipid desaturase activity" EXACT []
xref: Reactome:REACT_100550 "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O, Arabidopsis thaliana"
xref: Reactome:REACT_102736 "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O, Drosophila melanogaster"
xref: Reactome:REACT_105928 "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O, Rattus norvegicus"
xref: Reactome:REACT_106792 "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O, Schizosaccharomyces pombe"
xref: Reactome:REACT_107558 "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O, Dictyostelium discoideum"
xref: Reactome:REACT_115944 "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O, Gallus gallus"
xref: Reactome:REACT_19261 "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O, Homo sapiens"
xref: Reactome:REACT_29611 "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O, Xenopus tropicalis"
xref: Reactome:REACT_30855 "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O, Caenorhabditis elegans"
xref: Reactome:REACT_33970 "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O, Danio rerio"
xref: Reactome:REACT_34385 "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O, Oryza sativa"
xref: Reactome:REACT_78410 "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O, Taeniopygia guttata"
xref: Reactome:REACT_81491 "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O, Canis familiaris"
xref: Reactome:REACT_82356 "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O, Bos taurus"
xref: Reactome:REACT_82422 "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O, Mus musculus"
xref: Reactome:REACT_96577 "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O, Gallus gallus"
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0042285
name: xylosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a xylosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai]
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0042286
name: glutamate-1-semialdehyde 2,1-aminomutase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-4-amino-5-oxopentanoate = 5-aminolevulinate." [EC:5.4.3.8, RHEA:14268]
subset: gosubset_prok
synonym: "(S)-4-amino-5-oxopentanoate 4,5-aminomutase activity" EXACT [EC:5.4.3.8]
synonym: "glutamate-1-semialdehyde aminotransferase activity" EXACT [EC:5.4.3.8]
xref: EC:5.4.3.8
xref: KEGG:R02272
xref: MetaCyc:GSAAMINOTRANS-RXN
xref: RHEA:14268
is_a: GO:0016869 ! intramolecular transferase activity, transferring amino groups

[Term]
id: GO:0042287
name: MHC protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with major histocompatibility complex molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation." [GOC:jl]
comment: Note that this term does not include binding to the antigen peptide bound to the MHC protein, for this also annotate to 'peptide antigen binding ; GO:0042605' or one of its children.
synonym: "major histocompatibility complex binding" EXACT []
synonym: "major histocompatibility complex ligand" NARROW []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0042288
name: MHC class I protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with major histocompatibility complex class I molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation." [GOC:jl]
comment: Note that this term does not include binding to the antigen peptide bound to the MHC protein. Consider also annotating to the molecular function term 'peptide antigen binding ; GO:0042605' or one of its children.
synonym: "alpha-beta T cell receptor activity" RELATED []
synonym: "gamma-delta T cell receptor activity" RELATED []
synonym: "major histocompatibility complex class I binding" EXACT []
synonym: "major histocompatibility complex class I ligand" NARROW []
synonym: "T cell receptor activity" RELATED []
is_a: GO:0042287 ! MHC protein binding

[Term]
id: GO:0042289
name: MHC class II protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with major histocompatibility complex class II molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation." [GOC:jl]
comment: Note that this term does not include binding to the antigen peptide bound to the MHC protein. Consider also annotating to the molecular function term 'peptide antigen binding ; GO:0042605' or one of its children.
synonym: "major histocompatibility complex class II binding" EXACT []
synonym: "major histocompatibility complex class II ligand" NARROW []
is_a: GO:0042287 ! MHC protein binding

[Term]
id: GO:0042290
name: obsolete URM1 hydrolase activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it cannot be determined what its intended meaning was, because the term name is not found in the literature.
synonym: "URM1 hydrolase activity" EXACT []
is_obsolete: true
consider: GO:0019783

[Term]
id: GO:0042291
name: obsolete Hub1 hydrolase activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it cannot be determined what its intended meaning was, because the term name is not found in the literature.
synonym: "Hub1 hydrolase activity" EXACT []
is_obsolete: true
consider: GO:0019783

[Term]
id: GO:0042292
name: URM1 activating enzyme activity
namespace: molecular_function
def: "Catalysis of the activation of the small ubiquitin-related modifier URM1, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah]
is_a: GO:0008641 ! small protein activating enzyme activity

[Term]
id: GO:0042293
name: Hub1 activating enzyme activity
namespace: molecular_function
def: "Catalysis of the activation of the small ubiquitin-related modifier Hub1, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah]
is_a: GO:0008641 ! small protein activating enzyme activity

[Term]
id: GO:0042294
name: URM1 transferase activity
namespace: molecular_function
def: "Catalysis of the transfer of URM1 from one protein to another via the reaction X-URM1 + Y --> Y-URM1 + X, where both X-URM1 and Y-URM1 are covalent linkages." [GOC:mah, PMID:12826404]
is_a: GO:0019787 ! ubiquitin-like protein transferase activity

[Term]
id: GO:0042296
name: ISG15 transferase activity
namespace: molecular_function
def: "Catalysis of the transfer of ISG15 from one protein to another via the reaction X-ISG15 + Y --> Y-ISG15 + X, where both X-ISG15 and Y-ISG15 are covalent linkages." [GOC:mah, PMID:12826404]
synonym: "ISG15 conjugating enzyme activity" NARROW []
is_a: GO:0019787 ! ubiquitin-like protein transferase activity

[Term]
id: GO:0042297
name: vocal learning
namespace: biological_process
def: "A behavioral process whose outcome is a relatively long-lasting behavioral change whereby an organism modifies innate vocalizations to imitate sounds produced by others." [GOC:BHF, GOC:dos, GOC:rl, PMID:16418265, PMID:17035521]
comment: Examples include language learning by human infants and song learning in zebra finches.
xref: Wikipedia:Vocal_learning
is_a: GO:0031223 ! auditory behavior
is_a: GO:0098596 ! imitative learning
is_a: GO:0098598 ! learned vocalization behavior or vocal learning

[Term]
id: GO:0042299
name: lupeol synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-2,3-epoxysqualene = lupeol. This reaction is the cyclization of (S)-2,3-epoxysqualene (2,3-oxidosqualene) to lupeol." [MetaCyc:RXN-111, PMID:9883589]
synonym: "oxidosqualene:lupeol cyclase activity" EXACT [PMID:18033581]
xref: EC:5.4.99.-
xref: MetaCyc:RXN-111
is_a: GO:0031559 ! oxidosqualene cyclase activity

[Term]
id: GO:0042300
name: beta-amyrin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-2,3-epoxysqualene = beta-amyrin. This reaction is the cyclization and rearrangement of (S)-2,3-epoxysqualene (2,3-oxidosqualene) into beta-amyrin." [PMID:9746369]
synonym: "oxidosqualene:beta-amyrin cyclase activity" EXACT [PMID:18033581]
xref: EC:5.4.99.-
xref: MetaCyc:RXN-7570
is_a: GO:0031559 ! oxidosqualene cyclase activity

[Term]
id: GO:0042301
name: phosphate ion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with phosphate." [GOC:jl]
subset: gosubset_prok
is_a: GO:0043168 ! anion binding

[Term]
id: GO:0042302
name: structural constituent of cuticle
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0042303
name: molting cycle
namespace: biological_process
def: "The periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin, etc." [GOC:jl, ISBN:0198506732]
subset: goslim_pir
is_a: GO:0044707 ! single-multicellular organism process

[Term]
id: GO:0042304
name: regulation of fatty acid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils." [GOC:go_curators, GOC:jl]
subset: gosubset_prok
synonym: "regulation of fatty acid anabolism" EXACT []
synonym: "regulation of fatty acid biosynthesis" EXACT []
synonym: "regulation of fatty acid formation" EXACT []
synonym: "regulation of fatty acid synthesis" EXACT []
xref: Reactome:REACT_102284 "AMPK inhibits chREBP transcriptional activation activity, Caenorhabditis elegans"
xref: Reactome:REACT_104762 "AMPK inhibits chREBP transcriptional activation activity, Saccharomyces cerevisiae"
xref: Reactome:REACT_107124 "AMPK inhibits chREBP transcriptional activation activity, Gallus gallus"
xref: Reactome:REACT_108119 "AMPK inhibits chREBP transcriptional activation activity, Dictyostelium discoideum"
xref: Reactome:REACT_109849 "AMPK inhibits chREBP transcriptional activation activity, Oryza sativa"
xref: Reactome:REACT_109943 "AMPK inhibits chREBP transcriptional activation activity, Sus scrofa"
xref: Reactome:REACT_110809 "AMPK inhibits chREBP transcriptional activation activity, Mus musculus"
xref: Reactome:REACT_112072 "AMPK inhibits chREBP transcriptional activation activity, Danio rerio"
xref: Reactome:REACT_1988 "AMPK inhibits chREBP transcriptional activation activity, Homo sapiens"
xref: Reactome:REACT_28400 "AMPK inhibits chREBP transcriptional activation activity, Bos taurus"
xref: Reactome:REACT_28733 "AMPK inhibits chREBP transcriptional activation activity, Schizosaccharomyces pombe"
xref: Reactome:REACT_29554 "AMPK inhibits chREBP transcriptional activation activity, Rattus norvegicus"
xref: Reactome:REACT_79492 "AMPK inhibits chREBP transcriptional activation activity, Taeniopygia guttata"
xref: Reactome:REACT_84175 "AMPK inhibits chREBP transcriptional activation activity, Canis familiaris"
xref: Reactome:REACT_86711 "AMPK inhibits chREBP transcriptional activation activity, Drosophila melanogaster"
xref: Reactome:REACT_88294 "AMPK inhibits chREBP transcriptional activation activity, Xenopus tropicalis"
xref: Reactome:REACT_90865 "AMPK inhibits chREBP transcriptional activation activity, Arabidopsis thaliana"
is_a: GO:0019217 ! regulation of fatty acid metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0046890 ! regulation of lipid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006633 ! fatty acid biosynthetic process
relationship: regulates GO:0006633 ! fatty acid biosynthetic process

[Term]
id: GO:0042305
name: specification of segmental identity, mandibular segment
namespace: biological_process
def: "The specification of the characteristic structures of the mandibular segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437]
comment: See also the fly_anatomy.ontology term 'mandibular segment ; FBbt:00000012'.
is_a: GO:0007380 ! specification of segmental identity, head
relationship: part_of GO:0035289 ! posterior head segmentation

[Term]
id: GO:0042306
name: regulation of protein import into nucleus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of movement of proteins from the cytoplasm to the nucleus." [GOC:jl]
synonym: "regulation of protein import into cell nucleus" EXACT []
synonym: "regulation of protein transport from cytoplasm to nucleus" EXACT []
synonym: "regulation of protein-nucleus import" EXACT []
is_a: GO:0046822 ! regulation of nucleocytoplasmic transport
is_a: GO:1900180 ! regulation of protein localization to nucleus
is_a: GO:1903533 ! regulation of protein targeting
is_a: GO:1904589 ! regulation of protein import
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006606 ! protein import into nucleus
relationship: regulates GO:0006606 ! protein import into nucleus

[Term]
id: GO:0042307
name: positive regulation of protein import into nucleus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus." [GOC:jl]
synonym: "activation of protein import into nucleus" NARROW []
synonym: "positive regulation of protein import into cell nucleus" EXACT []
synonym: "positive regulation of protein transport from cytoplasm to nucleus" EXACT []
synonym: "positive regulation of protein-nucleus import" EXACT []
synonym: "stimulation of protein import into nucleus" NARROW []
synonym: "up regulation of protein import into nucleus" EXACT []
synonym: "up-regulation of protein import into nucleus" EXACT []
synonym: "upregulation of protein import into nucleus" EXACT []
is_a: GO:0042306 ! regulation of protein import into nucleus
is_a: GO:0046824 ! positive regulation of nucleocytoplasmic transport
is_a: GO:0090316 ! positive regulation of intracellular protein transport
is_a: GO:1900182 ! positive regulation of protein localization to nucleus
is_a: GO:1904591 ! positive regulation of protein import
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006606 ! protein import into nucleus
relationship: positively_regulates GO:0006606 ! protein import into nucleus

[Term]
id: GO:0042308
name: negative regulation of protein import into nucleus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus." [GOC:jl]
synonym: "down regulation of protein import into nucleus" EXACT []
synonym: "down-regulation of protein import into nucleus" EXACT []
synonym: "downregulation of protein import into nucleus" EXACT []
synonym: "inhibition of protein import into nucleus" NARROW []
synonym: "negative regulation of protein import into cell nucleus" EXACT []
synonym: "negative regulation of protein transport from cytoplasm to nucleus" EXACT []
synonym: "negative regulation of protein-nucleus import" EXACT []
is_a: GO:0042306 ! regulation of protein import into nucleus
is_a: GO:0046823 ! negative regulation of nucleocytoplasmic transport
is_a: GO:0090317 ! negative regulation of intracellular protein transport
is_a: GO:1900181 ! negative regulation of protein localization to nucleus
is_a: GO:1904590 ! negative regulation of protein import
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006606 ! protein import into nucleus
relationship: negatively_regulates GO:0006606 ! protein import into nucleus

[Term]
id: GO:0042309
name: homoiothermy
namespace: biological_process
def: "Any homoeostatic process in which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment." [ISBN:0192801023]
synonym: "antifreeze activity" RELATED []
synonym: "ice nucleation activity" RELATED []
synonym: "ice nucleation inhibitor activity" RELATED []
is_a: GO:0001659 ! temperature homeostasis

[Term]
id: GO:0042310
name: vasoconstriction
namespace: biological_process
def: "A decrease in the diameter of blood vessels, especially arteries, usually causing an increase in blood pressure." [ISBN:0192800752]
synonym: "negative regulation of blood vessel size" EXACT []
xref: Wikipedia:Vasoconstriction
is_a: GO:0050880 ! regulation of blood vessel size

[Term]
id: GO:0042311
name: vasodilation
namespace: biological_process
def: "An increase in the internal diameter of blood vessels, especially arterioles or capillaries, usually resulting in a decrease in blood pressure." [ISBN:0192800981]
synonym: "positive regulation of blood vessel size" EXACT []
synonym: "vasodilatation" EXACT []
xref: Wikipedia:Vasodilation
is_a: GO:0050880 ! regulation of blood vessel size

[Term]
id: GO:0042312
name: regulation of vasodilation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels." [GOC:jl]
synonym: "regulation of vasodilatation" EXACT []
is_a: GO:0050880 ! regulation of blood vessel size
is_a: GO:1903522 ! regulation of blood circulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042311 ! vasodilation
relationship: regulates GO:0042311 ! vasodilation

[Term]
id: GO:0042313
name: protein kinase C deactivation
namespace: biological_process
def: "Any process resulting in the inhibition or termination of the activity of protein kinase C." [GOC:bf]
synonym: "PKC deactivation" EXACT []
is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway

[Term]
id: GO:0042314
name: bacteriochlorophyll binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with bacteriochlorophyll, a form of chlorophyll found in photosynthetic bacteria, such as the purple and green bacteria. There are several types, designated a to g. Bacteriochlorophyll a and bacteriochlorophyll b are structurally similar to the chlorophyll a and chlorophyll b found in plants." [ISBN:0192800981]
subset: gosubset_prok
is_a: GO:0016168 ! chlorophyll binding

[Term]
id: GO:0042315
name: obsolete cytosol nonspecific dipeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of dipeptides, preferentially hydrophobic dipeptides including prolyl amino acids." [EC:3.4.13.18]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "cytosol non-specific dipeptidase activity" EXACT [EC:3.4.13.18]
synonym: "cytosol nonspecific dipeptidase activity" EXACT []
synonym: "diglycinase activity" EXACT [EC:3.4.13.18]
synonym: "Gly-Leu hydrolase activity" EXACT [EC:3.4.13.18]
synonym: "glycyl-glycine dipeptidase activity" NARROW [EC:3.4.13.18]
synonym: "glycyl-L-leucine dipeptidase activity" EXACT [EC:3.4.13.18]
synonym: "glycyl-L-leucine hydrolase activity" EXACT [EC:3.4.13.18]
synonym: "glycyl-L-leucine peptidase activity" EXACT [EC:3.4.13.18]
synonym: "glycyl-leucine dipeptidase activity" NARROW [EC:3.4.13.18]
synonym: "glycylleucine dipeptide hydrolase activity" EXACT [EC:3.4.13.18]
synonym: "glycylleucine hydrolase activity" EXACT [EC:3.4.13.18]
synonym: "glycylleucine peptidase activity" EXACT [EC:3.4.13.18]
synonym: "human cytosolic non-specific dipeptidase activity" EXACT [EC:3.4.13.18]
synonym: "iminodipeptidase activity" EXACT [EC:3.4.13.18]
synonym: "L-amino-acyl-L-amino-acid hydrolase activity" EXACT [EC:3.4.13.18]
synonym: "L-prolylglycine dipeptidase activity" EXACT [EC:3.4.13.18]
synonym: "N(2)-beta-alanylarginine dipeptidase activity" NARROW [EC:3.4.13.18]
synonym: "N2-beta-alanylarginine dipeptidase activity" EXACT [EC:3.4.13.18]
synonym: "non-specific dipeptidase activity" EXACT [EC:3.4.13.18]
synonym: "peptidase A activity" BROAD [EC:3.4.13.18]
synonym: "Pro-X dipeptidase activity" NARROW [EC:3.4.13.18]
synonym: "prolinase activity" NARROW [EC:3.4.13.18]
synonym: "prolyl dipeptidase activity" NARROW [EC:3.4.13.18]
synonym: "prolylglycine dipeptidase activity" NARROW [EC:3.4.13.18]
xref: EC:3.4.13.18
xref: MetaCyc:3.4.13.18-RXN
is_obsolete: true
replaced_by: GO:0016805

[Term]
id: GO:0042316
name: penicillin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any antibiotic that contains the condensed beta-lactamthiazolidine ring system. Penicillins are produced naturally during the growth of various microfungi of the genera Penicillium and Aspergillus." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "penicillin metabolism" EXACT []
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0030653 ! beta-lactam antibiotic metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0042317
name: penicillin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "penicillin breakdown" EXACT []
synonym: "penicillin catabolism" EXACT []
synonym: "penicillin degradation" EXACT []
is_a: GO:0030655 ! beta-lactam antibiotic catabolic process
is_a: GO:0042316 ! penicillin metabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process

[Term]
id: GO:0042318
name: penicillin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "penicillin anabolism" EXACT []
synonym: "penicillin biosynthesis" EXACT []
synonym: "penicillin formation" EXACT []
synonym: "penicillin synthesis" EXACT []
is_a: GO:0030654 ! beta-lactam antibiotic biosynthetic process
is_a: GO:0042316 ! penicillin metabolic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process

[Term]
id: GO:0042320
name: regulation of circadian sleep/wake cycle, REM sleep
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of rapid eye movement (REM) sleep." [GOC:jl, PMID:11506998]
synonym: "regulation of REM sleep" EXACT []
is_a: GO:0045187 ! regulation of circadian sleep/wake cycle, sleep
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042747 ! circadian sleep/wake cycle, REM sleep
relationship: regulates GO:0042747 ! circadian sleep/wake cycle, REM sleep

[Term]
id: GO:0042321
name: negative regulation of circadian sleep/wake cycle, sleep
namespace: biological_process
def: "Any process that stops, prevents or reduces the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:go_curators, GOC:jl, ISBN:0192800981]
synonym: "down regulation of circadian sleep/wake cycle, sleep" EXACT []
synonym: "down-regulation of circadian sleep/wake cycle, sleep" EXACT []
synonym: "downregulation of circadian sleep/wake cycle, sleep" EXACT []
synonym: "inhibition of circadian sleep/wake cycle, sleep" NARROW []
synonym: "negative regulation of sleep" EXACT []
is_a: GO:0042754 ! negative regulation of circadian rhythm
is_a: GO:0045187 ! regulation of circadian sleep/wake cycle, sleep
is_a: GO:0048521 ! negative regulation of behavior
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0050802 ! circadian sleep/wake cycle, sleep
relationship: negatively_regulates GO:0050802 ! circadian sleep/wake cycle, sleep

[Term]
id: GO:0042322
name: negative regulation of circadian sleep/wake cycle, REM sleep
namespace: biological_process
def: "Any process that stops, prevents or reduces the duration or quality of rapid eye movement (REM) sleep." [GOC:go_curators, GOC:jl]
synonym: "down regulation of circadian sleep/wake cycle, REM sleep" EXACT []
synonym: "down-regulation of circadian sleep/wake cycle, REM sleep" EXACT []
synonym: "downregulation of circadian sleep/wake cycle, REM sleep" EXACT []
synonym: "inhibition of circadian sleep/wake cycle, REM sleep" NARROW []
synonym: "negative regulation of REM sleep" EXACT []
is_a: GO:0042320 ! regulation of circadian sleep/wake cycle, REM sleep
is_a: GO:0042321 ! negative regulation of circadian sleep/wake cycle, sleep
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042747 ! circadian sleep/wake cycle, REM sleep
relationship: negatively_regulates GO:0042747 ! circadian sleep/wake cycle, REM sleep

[Term]
id: GO:0042323
name: negative regulation of circadian sleep/wake cycle, non-REM sleep
namespace: biological_process
def: "Any process that stops, prevents or reduces the duration or quality of non-rapid eye movement (NREM) sleep." [GOC:jl]
synonym: "down regulation of circadian sleep/wake cycle, non-REM sleep" EXACT []
synonym: "down-regulation of circadian sleep/wake cycle, non-REM sleep" EXACT []
synonym: "downregulation of circadian sleep/wake cycle, non-REM sleep" EXACT []
synonym: "inhibition of circadian sleep/wake cycle, non-REM sleep" NARROW []
synonym: "negative regulation of non-REM sleep" EXACT []
is_a: GO:0042321 ! negative regulation of circadian sleep/wake cycle, sleep
is_a: GO:0045188 ! regulation of circadian sleep/wake cycle, non-REM sleep
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042748 ! circadian sleep/wake cycle, non-REM sleep
relationship: negatively_regulates GO:0042748 ! circadian sleep/wake cycle, non-REM sleep

[Term]
id: GO:0042324
name: hypocretin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the hypocretin receptor." [GOC:ceb, PMID:11988773]
synonym: "hypocretin receptor ligand" NARROW []
synonym: "orexin receptor binding" EXACT []
synonym: "orexin receptor ligand" NARROW []
is_a: GO:0071855 ! neuropeptide receptor binding

[Term]
id: GO:0042325
name: regulation of phosphorylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule." [GOC:jl]
subset: gosubset_prok
is_a: GO:0019220 ! regulation of phosphate metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016310 ! phosphorylation
relationship: regulates GO:0016310 ! phosphorylation

[Term]
id: GO:0042326
name: negative regulation of phosphorylation
namespace: biological_process
def: "Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule." [GOC:jl]
subset: gosubset_prok
synonym: "down regulation of phosphorylation" EXACT []
synonym: "down-regulation of phosphorylation" EXACT []
synonym: "downregulation of phosphorylation" EXACT []
synonym: "inhibition of phosphorylation" NARROW []
is_a: GO:0042325 ! regulation of phosphorylation
is_a: GO:0045936 ! negative regulation of phosphate metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016310 ! phosphorylation
relationship: negatively_regulates GO:0016310 ! phosphorylation

[Term]
id: GO:0042327
name: positive regulation of phosphorylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule." [GOC:jl]
subset: gosubset_prok
synonym: "activation of phosphorylation" NARROW []
synonym: "stimulation of phosphorylation" NARROW []
synonym: "up regulation of phosphorylation" EXACT []
synonym: "up-regulation of phosphorylation" EXACT []
synonym: "upregulation of phosphorylation" EXACT []
is_a: GO:0042325 ! regulation of phosphorylation
is_a: GO:0045937 ! positive regulation of phosphate metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016310 ! phosphorylation
relationship: positively_regulates GO:0016310 ! phosphorylation

[Term]
id: GO:0042328
name: heparan sulfate N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + heparan sulfate = UDP + (N-acetyl-D-glucosaminyl)-heparan sulfate." [GOC:ma]
synonym: "heparan sulphate N-acetylglucosaminyltransferase activity" EXACT []
synonym: "heparin N-acetylglucosaminyltransferase activity" RELATED []
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0042329
name: structural constituent of collagen and cuticulin-based cuticle
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of a collagen and cuticulin-based cuticle. An example of this process is found in Caenorhabditis elegans." [GOC:jl, GOC:mtg_sensu]
synonym: "structural constituent of cuticle" BROAD []
is_a: GO:0042302 ! structural constituent of cuticle

[Term]
id: GO:0042330
name: taxis
namespace: biological_process
def: "The directed movement of a motile cell or organism in response to an external stimulus." [GOC:jl, ISBN:0192801023]
subset: gosubset_prok
synonym: "directed movement in response to stimulus" EXACT []
xref: Wikipedia:Taxis
is_a: GO:0040011 ! locomotion
relationship: part_of GO:0009605 ! response to external stimulus

[Term]
id: GO:0042331
name: phototaxis
namespace: biological_process
alt_id: GO:0046953
def: "The directed movement of a motile cell or organism in response to light." [GOC:jl, ISBN:0192800981]
synonym: "phototactic behavior" EXACT []
synonym: "phototactic behaviour" EXACT []
synonym: "taxis in response to light" EXACT []
xref: Wikipedia:Phototaxis
is_a: GO:0009416 ! response to light stimulus
is_a: GO:0009453 ! energy taxis

[Term]
id: GO:0042332
name: gravitaxis
namespace: biological_process
alt_id: GO:0048062
def: "The directed movement of a motile cell or organism in response to gravity." [GOC:jid, GOC:jl]
synonym: "geotactic behavior" EXACT []
synonym: "geotactic behaviour" EXACT []
synonym: "geotaxis" EXACT []
synonym: "gravitactic behavior" EXACT []
synonym: "gravitactic behaviour" EXACT []
synonym: "taxis in response to gravitational stimulus" EXACT []
synonym: "taxis in response to gravity" EXACT []
is_a: GO:0009629 ! response to gravity
is_a: GO:0042330 ! taxis

[Term]
id: GO:0042333
name: chemotaxis to oxidizable substrate
namespace: biological_process
def: "The directed movement of a motile cell or organism in response to the presence of an oxidizable substrate, for example, fructose." [GOC:jl, PMID:11029423]
synonym: "taxis in response to oxidizable substrate" EXACT []
is_a: GO:0006935 ! chemotaxis
is_a: GO:0009453 ! energy taxis

[Term]
id: GO:0042334
name: taxis to electron acceptor
namespace: biological_process
def: "The directed movement of a motile cell or organism in response to the presence of an alternative electron acceptor, for example, nitrate." [GOC:jl, PMID:11029423]
synonym: "taxis in response to electron acceptor" EXACT []
is_a: GO:0009453 ! energy taxis

[Term]
id: GO:0042335
name: cuticle development
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a cuticle, the outer layer of some animals and plants, which acts to prevent water loss." [ISBN:0192800825]
synonym: "cuticle anabolism" EXACT []
synonym: "cuticle biosynthesis" EXACT []
synonym: "cuticle biosynthetic process" EXACT []
synonym: "cuticle formation" EXACT []
synonym: "cuticle synthesis" EXACT []
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007275 ! multicellular organism development

[Term]
id: GO:0042336
name: obsolete cuticle development involved in protein-based cuticle molting cycle
namespace: biological_process
def: "OBSOLETE. Synthesis and deposition of a protein-based noncellular, hardened, or membranous secretion from an epithelial sheet, occurring as part of the molting cycle. Examples of this process are found in invertebrate species." [GOC:dph, GOC:mtg_sensu, GOC:tb]
comment: This term was made obsolete because 'protein-based cuticle' is an unnecessary grouping term.
synonym: "cuticle anabolism during molting" BROAD []
synonym: "cuticle biosynthetic process during molting" BROAD []
synonym: "cuticle development involved in protein-based cuticle molting cycle" EXACT []
synonym: "cuticle formation during molting" BROAD []
synonym: "cuticle synthesis during molting" BROAD []
is_obsolete: true
consider: GO:0042337
consider: GO:0042338

[Term]
id: GO:0042337
name: cuticle development involved in chitin-based cuticle molting cycle
namespace: biological_process
def: "The synthesis and deposition of a chitin-based non-cellular, hardened, or membranous secretion from an epithelial sheet, occurring as part of the molting cycle. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:jl, GOC:mtg_sensu, GOC:tb]
synonym: "chitin-based cuticle development during molting" RELATED [GOC:dph, GOC:tb]
synonym: "cuticle anabolism during molting" BROAD []
synonym: "cuticle biosynthetic process during molting" BROAD []
synonym: "cuticle formation during molting" BROAD []
synonym: "cuticle synthesis during molting" BROAD []
is_a: GO:0040003 ! chitin-based cuticle development
intersection_of: GO:0042335 ! cuticle development
intersection_of: part_of GO:0007591 ! molting cycle, chitin-based cuticle
relationship: part_of GO:0007591 ! molting cycle, chitin-based cuticle

[Term]
id: GO:0042338
name: cuticle development involved in collagen and cuticulin-based cuticle molting cycle
namespace: biological_process
def: "Synthesis and deposition of a collagen and cuticulin-based noncellular, hardened, or membranous secretion from an epithelial sheet, occurring as part of the molting cycle. An example of this process is found in Caenorhabditis elegans." [GOC:mtg_sensu]
synonym: "collagen and cuticulin-based cuticle development during molting" RELATED [GOC:dph, GOC:tb]
synonym: "cuticle anabolism during molting" BROAD []
synonym: "cuticle biosynthetic process during molting" BROAD []
synonym: "cuticle formation during molting" BROAD []
synonym: "cuticle synthesis during molting" BROAD []
is_a: GO:0040002 ! collagen and cuticulin-based cuticle development
intersection_of: GO:0042335 ! cuticle development
intersection_of: part_of GO:0018996 ! molting cycle, collagen and cuticulin-based cuticle
relationship: part_of GO:0018996 ! molting cycle, collagen and cuticulin-based cuticle

[Term]
id: GO:0042339
name: keratan sulfate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues." [GOC:go_curators]
subset: gosubset_prok
synonym: "keratan sulfate metabolism" EXACT []
synonym: "keratan sulphate metabolic process" EXACT []
synonym: "keratan sulphate metabolism" EXACT []
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0043436 ! oxoacid metabolic process
is_a: GO:1903510 ! mucopolysaccharide metabolic process

[Term]
id: GO:0042340
name: keratan sulfate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues." [GOC:go_curators]
subset: gosubset_prok
synonym: "keratan sulfate breakdown" EXACT []
synonym: "keratan sulfate catabolism" EXACT []
synonym: "keratan sulfate degradation" EXACT []
synonym: "keratan sulphate catabolic process" EXACT []
synonym: "keratan sulphate catabolism" EXACT []
is_a: GO:0006027 ! glycosaminoglycan catabolic process
is_a: GO:0042339 ! keratan sulfate metabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0044712 ! single-organism catabolic process

[Term]
id: GO:0042341
name: cyanogenic glycoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cyanogenic glycosides, any glycoside containing a cyano group that is released as hydrocyanic acid on acid hydrolysis; such compounds occur in the kernels of various fruits." [ISBN:0198506732]
subset: gosubset_prok
synonym: "cyanogenic glycoside metabolism" EXACT []
is_a: GO:0016137 ! glycoside metabolic process
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0050898 ! nitrile metabolic process

[Term]
id: GO:0042342
name: cyanogenic glycoside catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cyanogenic glycosides, any glycoside containing a cyano group that is released as hydrocyanic acid on acid hydrolysis; such compounds occur in the kernels of various fruits." [ISBN:0198506732]
subset: gosubset_prok
synonym: "cyanogenic glycoside breakdown" EXACT []
synonym: "cyanogenic glycoside catabolism" EXACT []
synonym: "cyanogenic glycoside degradation" EXACT []
is_a: GO:0016139 ! glycoside catabolic process
is_a: GO:0042341 ! cyanogenic glycoside metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0050899 ! nitrile catabolic process

[Term]
id: GO:0042343
name: indole glucosinolate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of indole glucosinolates. Glucosinolates are sulfur-containing compounds that have a common structure linked to an R group derived from tryptophan; indoles are biologically active substances based on 2,3-benzopyrrole, formed during the catabolism of tryptophan." [http://www.onelook.com/]
subset: gosubset_prok
synonym: "indole glucosinolate metabolism" EXACT []
is_a: GO:0019760 ! glucosinolate metabolic process
is_a: GO:0042430 ! indole-containing compound metabolic process

[Term]
id: GO:0042344
name: indole glucosinolate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of indole glucosinolates, sulfur-containing compounds that have a common structure linked to an R group derived from tryptophan." [http://www.onelook.com]
subset: gosubset_prok
synonym: "indole glucosinolate breakdown" EXACT []
synonym: "indole glucosinolate catabolism" EXACT []
synonym: "indole glucosinolate degradation" EXACT []
is_a: GO:0019762 ! glucosinolate catabolic process
is_a: GO:0042343 ! indole glucosinolate metabolic process
is_a: GO:0042436 ! indole-containing compound catabolic process

[Term]
id: GO:0042345
name: regulation of NF-kappaB import into nucleus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:jl, ISBN:0198506732]
synonym: "regulation of NF-kappaB import into cell nucleus" EXACT []
synonym: "regulation of NF-kappaB transport from cytoplasm to nucleus" EXACT []
synonym: "regulation of NF-kappaB-nucleus import" EXACT []
is_a: GO:0042990 ! regulation of transcription factor import into nucleus
is_a: GO:0043122 ! regulation of I-kappaB kinase/NF-kappaB signaling
is_a: GO:0090087 ! regulation of peptide transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042348 ! NF-kappaB import into nucleus
relationship: regulates GO:0042348 ! NF-kappaB import into nucleus

[Term]
id: GO:0042346
name: positive regulation of NF-kappaB import into nucleus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:jl, ISBN:0198506732]
synonym: "activation of NF-kappaB import into nucleus" NARROW []
synonym: "positive regulation of NF-kappaB import into cell nucleus" EXACT []
synonym: "positive regulation of NF-kappaB transport from cytoplasm to nucleus" EXACT []
synonym: "positive regulation of NF-kappaB-nucleus import" EXACT []
synonym: "stimulation of NF-kappaB import into nucleus" NARROW []
synonym: "up regulation of NF-kappaB import into nucleus" EXACT []
synonym: "up-regulation of NF-kappaB import into nucleus" EXACT []
synonym: "upregulation of NF-kappaB import into nucleus" EXACT []
is_a: GO:0042345 ! regulation of NF-kappaB import into nucleus
is_a: GO:0042993 ! positive regulation of transcription factor import into nucleus
is_a: GO:0043123 ! positive regulation of I-kappaB kinase/NF-kappaB signaling
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042348 ! NF-kappaB import into nucleus
relationship: positively_regulates GO:0042348 ! NF-kappaB import into nucleus

[Term]
id: GO:0042347
name: negative regulation of NF-kappaB import into nucleus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:jl, ISBN:0198506732]
synonym: "down regulation of NF-kappaB import into nucleus" EXACT []
synonym: "down-regulation of NF-kappaB import into nucleus" EXACT []
synonym: "downregulation of NF-kappaB import into nucleus" EXACT []
synonym: "inhibition of NF-kappaB import into nucleus" NARROW []
synonym: "negative regulation of NF-kappaB import into cell nucleus" EXACT []
synonym: "negative regulation of NF-kappaB transport from cytoplasm to nucleus" EXACT []
synonym: "negative regulation of NF-kappaB-nucleus import" EXACT []
is_a: GO:0042345 ! regulation of NF-kappaB import into nucleus
is_a: GO:0042992 ! negative regulation of transcription factor import into nucleus
is_a: GO:0043124 ! negative regulation of I-kappaB kinase/NF-kappaB signaling
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042348 ! NF-kappaB import into nucleus
relationship: negatively_regulates GO:0042348 ! NF-kappaB import into nucleus

[Term]
id: GO:0042348
name: NF-kappaB import into nucleus
namespace: biological_process
def: "The directed movement of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:jl, ISBN:0198506732]
synonym: "NF-kappaB import into cell nucleus" EXACT []
synonym: "NF-kappaB protein-nucleus import" EXACT []
synonym: "NF-kappaB transport from cytoplasm to nucleus" EXACT []
synonym: "NF-kappaB-nucleus import" EXACT []
synonym: "NF-KB import into nucleus" EXACT [GOC:bf]
is_a: GO:0015833 ! peptide transport
is_a: GO:0031503 ! protein complex localization
is_a: GO:0042991 ! transcription factor import into nucleus
relationship: part_of GO:0007249 ! I-kappaB kinase/NF-kappaB signaling

[Term]
id: GO:0042349
name: guiding stereospecific synthesis activity
namespace: molecular_function
def: "The orientation of free radical substrates in such a way that only a particular stereoisomer is synthesized by an enzyme. Best characterized as a function during lignan biosynthesis." [GOC:ma]
synonym: "dirigent protein" NARROW []
is_a: GO:0030234 ! enzyme regulator activity

[Term]
id: GO:0042350
name: GDP-L-fucose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of GDP-L-fucose, a substance composed of L-fucose in glycosidic linkage with guanosine diphosphate." [GOC:jl]
subset: gosubset_prok
synonym: "GDP-L-fucose anabolism" EXACT []
synonym: "GDP-L-fucose biosynthesis" EXACT []
synonym: "GDP-L-fucose formation" EXACT []
synonym: "GDP-L-fucose synthesis" EXACT []
is_a: GO:0009226 ! nucleotide-sugar biosynthetic process
is_a: GO:0046368 ! GDP-L-fucose metabolic process

[Term]
id: GO:0042351
name: 'de novo' GDP-L-fucose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of GDP-L-fucose from GDP-D-mannose via GDP-4-dehydro-6-deoxy-D-mannose, requiring the functions of GDP-mannose 4,6-dehydratase (EC:4.2.1.47) and GDP-L-fucose synthase (EC:1.1.1.271)." [EC:1.1.1.271, PMID:11030750]
subset: gosubset_prok
synonym: "'de novo' GDP-L-fucose anabolism" EXACT []
synonym: "'de novo' GDP-L-fucose biosynthesis" EXACT []
synonym: "'de novo' GDP-L-fucose formation" EXACT []
synonym: "'de novo' GDP-L-fucose synthesis" EXACT []
synonym: "GDP-L-fucose biosynthesis, de novo pathway" EXACT []
synonym: "GDP-L-fucose biosynthetic process, de novo pathway" EXACT []
xref: MetaCyc:PWY-66
is_a: GO:0042350 ! GDP-L-fucose biosynthetic process

[Term]
id: GO:0042352
name: GDP-L-fucose salvage
namespace: biological_process
def: "The formation of GDP-L-fucose from L-fucose, without de novo synthesis. L-fucose is phosphorylated by fucokinase and then converted by fucose-1-phosphate guanylyltransferase (EC:2.7.7.30)." [GOC:ma]
subset: gosubset_prok
synonym: "GDP-L-fucose biosynthesis, salvage pathway" EXACT []
synonym: "GDP-L-fucose biosynthetic process, salvage pathway" EXACT []
xref: MetaCyc:PWY-6
is_a: GO:0042350 ! GDP-L-fucose biosynthetic process
is_a: GO:0043173 ! nucleotide salvage

[Term]
id: GO:0042353
name: fucose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of fucose (6-deoxygalactose)." [GOC:jl]
subset: gosubset_prok
synonym: "fucose anabolism" EXACT []
synonym: "fucose biosynthesis" EXACT []
synonym: "fucose formation" EXACT []
synonym: "fucose synthesis" EXACT []
is_a: GO:0006004 ! fucose metabolic process
is_a: GO:0019319 ! hexose biosynthetic process

[Term]
id: GO:0042354
name: L-fucose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving L-fucose, 6-deoxy-L-galactose, a sugar that occurs in fucans, a class of polysaccharides in seaweeds, especially Fucus species, and in the cell wall matrix of higher plants." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "L-fucose metabolism" EXACT []
is_a: GO:0006004 ! fucose metabolic process

[Term]
id: GO:0042355
name: L-fucose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-fucose (6-deoxy-Lgalactose)." [GOC:jl]
subset: gosubset_prok
synonym: "L-fucose breakdown" EXACT []
synonym: "L-fucose catabolism" EXACT []
synonym: "L-fucose degradation" EXACT []
is_a: GO:0019317 ! fucose catabolic process
is_a: GO:0042354 ! L-fucose metabolic process

[Term]
id: GO:0042356
name: GDP-4-dehydro-D-rhamnose reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-6-deoxy-D-mannose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H+. In the reverse reaction, a mixture of GDP-D-rhamnose and its C-4 epimer is formed." [BRENDA:1.1.1.187, EC:1.1.1.187]
subset: gosubset_prok
synonym: "GDP-4-keto-6-deoxy-D-mannose reductase activity" EXACT [EC:1.1.1.187]
synonym: "GDP-4-keto-D-rhamnose reductase activity" EXACT [EC:1.1.1.187]
synonym: "GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase activity" EXACT [EC:1.1.1.187]
synonym: "guanosine diphosphate-4-keto-D-rhamnose reductase activity" EXACT [EC:1.1.1.187]
xref: EC:1.1.1.187
xref: MetaCyc:GDP-4-DEHYDRO-D-RHAMNOSE-REDUCTASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0042357
name: thiamine diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle." [CHEBI:45931, GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "thiamin diphosphate metabolic process" EXACT [GOC:curators]
synonym: "thiamin diphosphate metabolism" EXACT []
synonym: "thiamin pyrophosphate metabolic process" EXACT []
synonym: "thiamin pyrophosphate metabolism" EXACT []
synonym: "thiamine diphosphate metabolism" EXACT []
synonym: "thiamine pyrophosphate metabolic process" EXACT []
synonym: "thiamine pyrophosphate metabolism" EXACT []
synonym: "TPP metabolic process" EXACT []
synonym: "TPP metabolism" EXACT []
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0006732 ! coenzyme metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:0072527 ! pyrimidine-containing compound metabolic process

[Term]
id: GO:0042358
name: thiamine diphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "thiamin diphosphate breakdown" EXACT []
synonym: "thiamin diphosphate catabolic process" EXACT []
synonym: "thiamin diphosphate catabolism" EXACT []
synonym: "thiamin diphosphate degradation" EXACT []
synonym: "thiamin pyrophosphate catabolic process" EXACT []
synonym: "thiamin pyrophosphate catabolism" EXACT []
synonym: "thiamine diphosphate catabolism" EXACT []
synonym: "thiamine pyrophosphate catabolic process" EXACT []
synonym: "thiamine pyrophosphate catabolism" EXACT []
synonym: "TPP catabolic process" EXACT []
synonym: "TPP catabolism" EXACT []
is_a: GO:0009109 ! coenzyme catabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042357 ! thiamine diphosphate metabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0046434 ! organophosphate catabolic process
is_a: GO:0072529 ! pyrimidine-containing compound catabolic process

[Term]
id: GO:0042359
name: vitamin D metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)." [CHEBI:27300, GOC:mah, ISBN:0471331309]
subset: gosubset_prok
synonym: "calciferol metabolic process" NARROW []
synonym: "calciferol metabolism" NARROW []
synonym: "cholecalciferol metabolic process" NARROW []
synonym: "cholecalciferol metabolism" NARROW []
synonym: "ergocalciferol metabolic process" NARROW []
synonym: "ergocalciferol metabolism" NARROW []
synonym: "vitamin D metabolism" EXACT []
xref: Reactome:REACT_102721 "Vitamin D (calciferol) metabolism, Gallus gallus"
xref: Reactome:REACT_105134 "Vitamin D (calciferol) metabolism, Danio rerio"
xref: Reactome:REACT_110700 "Vitamin D (calciferol) metabolism, Canis familiaris"
xref: Reactome:REACT_13523 "Vitamin D (calciferol) metabolism, Homo sapiens"
xref: Reactome:REACT_33174 "Vitamin D (calciferol) metabolism, Drosophila melanogaster"
xref: Reactome:REACT_33646 "Vitamin D (calciferol) metabolism, Mus musculus"
xref: Reactome:REACT_34030 "Vitamin D (calciferol) metabolism, Taeniopygia guttata"
xref: Reactome:REACT_78523 "Vitamin D (calciferol) metabolism, Sus scrofa"
xref: Reactome:REACT_89299 "Vitamin D (calciferol) metabolism, Rattus norvegicus"
xref: Reactome:REACT_90255 "Vitamin D (calciferol) metabolism, Xenopus tropicalis"
xref: Reactome:REACT_92314 "Vitamin D (calciferol) metabolism, Bos taurus"
is_a: GO:0006066 ! alcohol metabolic process
is_a: GO:0006775 ! fat-soluble vitamin metabolic process
is_a: GO:0008202 ! steroid metabolic process

[Term]
id: GO:0042360
name: vitamin E metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "alpha-tocopherol metabolic process" NARROW []
synonym: "alpha-tocopherol metabolism" NARROW []
synonym: "tocopherol metabolic process" EXACT []
synonym: "tocopherol metabolism" EXACT []
synonym: "vitamin E metabolism" EXACT []
is_a: GO:0006775 ! fat-soluble vitamin metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process

[Term]
id: GO:0042361
name: menaquinone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of menaquinones, any of the quinone-derived compounds synthesized by intestinal bacteria. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones have vitamin K activity and are known as vitamin K2." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k]
subset: gosubset_prok
synonym: "menaquinone breakdown" EXACT []
synonym: "menaquinone catabolism" EXACT []
synonym: "menaquinone degradation" EXACT []
synonym: "menatetrenone catabolic process" EXACT []
synonym: "menatetrenone catabolism" EXACT []
synonym: "multiprenylmenaquinone catabolic process" EXACT []
synonym: "multiprenylmenaquinone catabolism" EXACT []
synonym: "vitamin K2 catabolic process" EXACT []
synonym: "vitamin K2 catabolism" EXACT []
is_a: GO:0009233 ! menaquinone metabolic process
is_a: GO:1901662 ! quinone catabolic process

[Term]
id: GO:0042362
name: fat-soluble vitamin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "fat-soluble vitamin anabolism" EXACT []
synonym: "fat-soluble vitamin biosynthesis" EXACT []
synonym: "fat-soluble vitamin formation" EXACT []
synonym: "fat-soluble vitamin synthesis" EXACT []
is_a: GO:0006775 ! fat-soluble vitamin metabolic process
is_a: GO:0009110 ! vitamin biosynthetic process

[Term]
id: GO:0042363
name: fat-soluble vitamin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "fat-soluble vitamin breakdown" EXACT []
synonym: "fat-soluble vitamin catabolism" EXACT []
synonym: "fat-soluble vitamin degradation" EXACT []
is_a: GO:0006775 ! fat-soluble vitamin metabolic process
is_a: GO:0009111 ! vitamin catabolic process

[Term]
id: GO:0042364
name: water-soluble vitamin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any of a diverse group of vitamins that are soluble in water." [GOC:jl]
subset: gosubset_prok
synonym: "water-soluble vitamin anabolism" EXACT []
synonym: "water-soluble vitamin biosynthesis" EXACT []
synonym: "water-soluble vitamin formation" EXACT []
synonym: "water-soluble vitamin synthesis" EXACT []
is_a: GO:0006767 ! water-soluble vitamin metabolic process
is_a: GO:0009110 ! vitamin biosynthetic process

[Term]
id: GO:0042365
name: water-soluble vitamin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any of a diverse group of vitamins that are soluble in water." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html]
subset: gosubset_prok
synonym: "water-soluble vitamin breakdown" EXACT []
synonym: "water-soluble vitamin catabolism" EXACT []
synonym: "water-soluble vitamin degradation" EXACT []
is_a: GO:0006767 ! water-soluble vitamin metabolic process
is_a: GO:0009111 ! vitamin catabolic process

[Term]
id: GO:0042366
name: cobalamin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:go_curators]
subset: gosubset_prok
synonym: "cobalamin breakdown" EXACT []
synonym: "cobalamin catabolism" EXACT []
synonym: "cobalamin degradation" EXACT []
synonym: "vitamin B12 catabolic process" EXACT []
synonym: "vitamin B12 catabolism" EXACT []
is_a: GO:0009235 ! cobalamin metabolic process
is_a: GO:0033015 ! tetrapyrrole catabolic process
is_a: GO:0042365 ! water-soluble vitamin catabolic process

[Term]
id: GO:0042367
name: biotin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid." [ISBN:0198506732]
subset: gosubset_prok
synonym: "biotin breakdown" EXACT []
synonym: "biotin catabolism" EXACT []
synonym: "biotin degradation" EXACT []
synonym: "vitamin B7 catabolic process" EXACT []
synonym: "vitamin B7 catabolism" EXACT []
synonym: "vitamin H catabolic process" EXACT []
synonym: "vitamin H catabolism" EXACT []
is_a: GO:0006768 ! biotin metabolic process
is_a: GO:0042365 ! water-soluble vitamin catabolic process
is_a: GO:0043605 ! cellular amide catabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process

[Term]
id: GO:0042368
name: vitamin D biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)." [CHEBI:27300, GOC:mah, ISBN:0471331309]
subset: gosubset_prok
synonym: "calciferol biosynthesis" NARROW []
synonym: "calciferol biosynthetic process" NARROW []
synonym: "cholecalciferol biosynthesis" NARROW []
synonym: "cholecalciferol biosynthetic process" NARROW []
synonym: "ergocalciferol biosynthesis" NARROW []
synonym: "ergocalciferol biosynthetic process" NARROW []
synonym: "vitamin D anabolism" EXACT []
synonym: "vitamin D biosynthesis" EXACT []
synonym: "vitamin D formation" EXACT []
synonym: "vitamin D synthesis" EXACT []
is_a: GO:0006694 ! steroid biosynthetic process
is_a: GO:0042359 ! vitamin D metabolic process
is_a: GO:0042362 ! fat-soluble vitamin biosynthetic process
is_a: GO:0046165 ! alcohol biosynthetic process

[Term]
id: GO:0042369
name: vitamin D catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)." [CHEBI:27300, GOC:mah, ISBN:0471331309]
subset: gosubset_prok
synonym: "calciferol catabolic process" NARROW []
synonym: "calciferol catabolism" NARROW []
synonym: "cholecalciferol biosynthesis" NARROW []
synonym: "cholecalciferol biosynthetic process" NARROW []
synonym: "ergocalciferol biosynthesis" NARROW []
synonym: "ergocalciferol biosynthetic process" NARROW []
synonym: "vitamin D breakdown" EXACT []
synonym: "vitamin D catabolism" EXACT []
synonym: "vitamin D degradation" EXACT []
is_a: GO:0006706 ! steroid catabolic process
is_a: GO:0042359 ! vitamin D metabolic process
is_a: GO:0042363 ! fat-soluble vitamin catabolic process
is_a: GO:0046164 ! alcohol catabolic process

[Term]
id: GO:0042370
name: thiamine diphosphate dephosphorylation
namespace: biological_process
def: "The removal of one or more phosphate groups from thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "thiamin diphosphate dephosphorylation" EXACT [GOC:curators]
synonym: "TPP dephosphorylation" EXACT []
is_a: GO:0042357 ! thiamine diphosphate metabolic process

[Term]
id: GO:0042371
name: vitamin K biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k]
subset: gosubset_prok
synonym: "naphthoquinone metabolic process" BROAD []
synonym: "naphthoquinone metabolism" BROAD []
synonym: "vitamin K anabolism" EXACT []
synonym: "vitamin K biosynthesis" EXACT []
synonym: "vitamin K formation" EXACT []
synonym: "vitamin K synthesis" EXACT []
is_a: GO:0042362 ! fat-soluble vitamin biosynthetic process
is_a: GO:0042373 ! vitamin K metabolic process
is_a: GO:1901663 ! quinone biosynthetic process

[Term]
id: GO:0042372
name: phylloquinone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phylloquinone, vitamin K1, a quinone-derived compound synthesized by green plants." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k]
subset: gosubset_prok
synonym: "phylloquinone anabolism" EXACT []
synonym: "phylloquinone biosynthesis" EXACT []
synonym: "phylloquinone formation" EXACT []
synonym: "phylloquinone synthesis" EXACT []
synonym: "phytomenadione biosynthesis" EXACT []
synonym: "phytomenadione biosynthetic process" EXACT []
synonym: "phytonadione biosynthesis" EXACT []
synonym: "phytonadione biosynthetic process" EXACT []
synonym: "phytylmenaquinone biosynthesis" EXACT []
synonym: "phytylmenaquinone biosynthetic process" EXACT []
synonym: "vitamin K1 biosynthesis" EXACT []
synonym: "vitamin K1 biosynthetic process" EXACT []
xref: MetaCyc:PWY-5027
is_a: GO:0042374 ! phylloquinone metabolic process
is_a: GO:1901663 ! quinone biosynthetic process

[Term]
id: GO:0042373
name: vitamin K metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals. Vitamin K substances share a methylated naphthoquinone ring structure and vary in the aliphatic side chains attached to the molecule." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k]
subset: gosubset_prok
synonym: "naphthoquinone metabolic process" BROAD []
synonym: "naphthoquinone metabolism" BROAD []
synonym: "vitamin K metabolism" EXACT []
is_a: GO:0006775 ! fat-soluble vitamin metabolic process
is_a: GO:1901661 ! quinone metabolic process

[Term]
id: GO:0042374
name: phylloquinone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phylloquinone, a quinone-derived compound synthesized by green plants. Phylloquinone has vitamin K activity and is known as vitamin K1." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k]
subset: gosubset_prok
synonym: "phylloquinone metabolism" EXACT []
synonym: "phytomenadione metabolic process" EXACT []
synonym: "phytomenadione metabolism" EXACT []
synonym: "phytonadione metabolic process" EXACT []
synonym: "phytonadione metabolism" EXACT []
synonym: "phytylmenaquinone metabolic process" EXACT []
synonym: "phytylmenaquinone metabolism" EXACT []
synonym: "vitamin K1 metabolic process" EXACT []
synonym: "vitamin K1 metabolism" EXACT []
is_a: GO:1901661 ! quinone metabolic process

[Term]
id: GO:0042376
name: phylloquinone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phylloquinone, vitamin K1, a quinone-derived compound synthesized by green plants." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k]
subset: gosubset_prok
synonym: "phylloquinone breakdown" EXACT []
synonym: "phylloquinone catabolism" EXACT []
synonym: "phylloquinone degradation" EXACT []
synonym: "phytomenadione catabolic process" EXACT []
synonym: "phytomenadione catabolism" EXACT []
synonym: "phytonadione catabolic process" EXACT []
synonym: "phytonadione catabolism" EXACT []
synonym: "phytylmenaquinone catabolic process" EXACT []
synonym: "phytylmenaquinone catabolism" EXACT []
synonym: "vitamin K1 catabolic process" EXACT []
synonym: "vitamin K1 catabolism" EXACT []
is_a: GO:0042374 ! phylloquinone metabolic process
is_a: GO:1901662 ! quinone catabolic process

[Term]
id: GO:0042377
name: vitamin K catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k]
subset: gosubset_prok
synonym: "naphthoquinone catabolic process" EXACT []
synonym: "naphthoquinone catabolism" EXACT []
synonym: "vitamin K breakdown" EXACT []
synonym: "vitamin K catabolism" EXACT []
synonym: "vitamin K degradation" EXACT []
is_a: GO:0042363 ! fat-soluble vitamin catabolic process
is_a: GO:0042373 ! vitamin K metabolic process
is_a: GO:1901662 ! quinone catabolic process

[Term]
id: GO:0042379
name: chemokine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any chemokine receptor." [GOC:ai]
synonym: "chemokine receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein coupled receptor binding
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0042380
name: hydroxymethylbutenyl pyrophosphate reductase activity
namespace: molecular_function
def: "Catalysis of the formation of both isopentenyl pyrophosphate and dimethylallyl pyrophosphate from (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate." [GOC:js]
comment: Note that the enzyme performing this function has only recently been characterized, and not completely (see PMID:11818558). The common and systematic names have been suggested by TIGR, who have recently compiled an HMM model for this gene (TIGR00216). The enzyme appears to catalyze the final step in the non-mevalonate terpene biosynthesis pathway. Its two products, isopentenyl pyrophosphate and dimethylallyl pyrophosphate, are apparently generated from a common intermediate formed by the enzyme. The mechanism and identity of the reductant have not yet been determined.
subset: gosubset_prok
synonym: "(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming)" EXACT []
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0042381
name: hemolymph coagulation
namespace: biological_process
def: "Any process in which factors in the hemolymph (the invertebrate equivalent of vertebrate blood and lymph) precipitate into insoluble clots in order to prevent loss of body fluid, and at the same time prevent the movement of microbes. Hemolymph coagulation is also part of the invertebrate humoral immune response." [GOC:jl, ISBN:0198506732, PMID:10561606, PMID:11915949]
synonym: "hemolymph clotting" EXACT []
is_a: GO:0006959 ! humoral immune response
is_a: GO:0007599 ! hemostasis
is_a: GO:0045087 ! innate immune response
is_a: GO:0050817 ! coagulation
relationship: part_of GO:0042060 ! wound healing

[Term]
id: GO:0042382
name: paraspeckles
namespace: cellular_component
def: "Discrete subnuclear bodies in the interchromatin nucleoplasmic space, often located adjacent to nuclear specks. 10-20 paraspeckles are typically found in human cell nuclei." [GOC:jl, PMID:11790299]
xref: Wikipedia:Paraspeckle
is_a: GO:0016604 ! nuclear body

[Term]
id: GO:0042383
name: sarcolemma
namespace: cellular_component
def: "The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers." [ISBN:0198506732]
xref: Wikipedia:Sarcolemma
is_a: GO:0005886 ! plasma membrane

[Term]
id: GO:0042384
name: cilium assembly
namespace: biological_process
def: "The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.
synonym: "ciliogenesis" EXACT []
synonym: "cilium biogenesis" RELATED [GOC:mah]
synonym: "microtubule-based flagellum assembly" EXACT []
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
is_a: GO:0030031 ! cell projection assembly
is_a: GO:0044782 ! cilium organization
is_a: GO:0070925 ! organelle assembly
relationship: part_of GO:0060271 ! cilium morphogenesis

[Term]
id: GO:0042385
name: myosin III complex
namespace: cellular_component
def: "A myosin complex containing a class III myosin heavy chain and associated light chains; myosin III is monomeric myosin that serves as a link between the cytoskeleton and the signaling complex involved in phototransduction, and differs from all other myosins in having an N-terminal kinase domain." [GOC:jl, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0042386
name: hemocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the characteristics of a mature hemocyte. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [CL:0000387, GOC:jl, GOC:mtg_sensu, PMID:9550723]
synonym: "arthropod blood cell differentiation" EXACT []
is_a: GO:0002376 ! immune system process
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0042387
name: plasmatocyte differentiation
namespace: biological_process
def: "The process in which a hemocyte precursor cell acquires the characteristics of the phagocytic blood-cell type, the plasmatocyte. Plasmatocytes are a class of arthropod hemocytes important in the cellular defense response." [PMID:11921077, PMID:8174791]
is_a: GO:0042386 ! hemocyte differentiation

[Term]
id: GO:0042388
name: gibberellic acid mediated signaling pathway, G-alpha-dependent
namespace: biological_process
def: "A series of molecular signals mediated by the detection of gibberellic acid and dependent on the coupling of the alpha subunit of G proteins to the hormone receptors." [GOC:pj, PMID:11027362]
synonym: "gibberellic acid mediated signalling, G-alpha-dependent" EXACT []
is_a: GO:0009740 ! gibberellic acid mediated signaling pathway

[Term]
id: GO:0042389
name: omega-3 fatty acid desaturase activity
namespace: molecular_function
def: "Catalysis of the introduction of an omega-3 double bond into the fatty acid hydrocarbon chain." [GOC:jl, PMID:9037020]
xref: EC:1.14.99.-
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0042390
name: gibberellic acid mediated signaling pathway, G-alpha-independent
namespace: biological_process
def: "A series of molecular signals mediated by the detection of gibberellic acid and not dependent on the coupling of the alpha subunit of G proteins to the hormone receptors." [GOC:pj, PMID:11027362]
synonym: "gibberellic acid mediated signalling, G-alpha-independent" EXACT []
is_a: GO:0009740 ! gibberellic acid mediated signaling pathway

[Term]
id: GO:0042391
name: regulation of membrane potential
namespace: biological_process
def: "Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, GOC:mtg_cardio, GOC:tb, ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0042392
name: sphingosine-1-phosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: sphingosine 1-phosphate + H2O = sphingosine + phosphate." [GOC:jl, PMID:11331102]
synonym: "sphingosine-1-phosphate phosphohydrolase activity" EXACT []
synonym: "SPP phosphatase activity" EXACT []
synonym: "SPPase activity" EXACT []
xref: MetaCyc:RXN3DJ-25
xref: Reactome:REACT_100668 "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular], Bos taurus"
xref: Reactome:REACT_101117 "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP], Gallus gallus"
xref: Reactome:REACT_102023 "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP], Oryza sativa"
xref: Reactome:REACT_104534 "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP], Rattus norvegicus"
xref: Reactome:REACT_108066 "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular], Rattus norvegicus"
xref: Reactome:REACT_108530 "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP], Arabidopsis thaliana"
xref: Reactome:REACT_109324 "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP], Rattus norvegicus"
xref: Reactome:REACT_110590 "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP], Danio rerio"
xref: Reactome:REACT_113452 "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP], Schizosaccharomyces pombe"
xref: Reactome:REACT_114519 "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP], Saccharomyces cerevisiae"
xref: Reactome:REACT_19185 "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP], Homo sapiens"
xref: Reactome:REACT_19309 "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular], Homo sapiens"
xref: Reactome:REACT_19392 "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP], Homo sapiens"
xref: Reactome:REACT_30592 "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP], Xenopus tropicalis"
xref: Reactome:REACT_30982 "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP], Bos taurus"
xref: Reactome:REACT_32297 "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP], Gallus gallus"
xref: Reactome:REACT_32425 "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP], Bos taurus"
xref: Reactome:REACT_32451 "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP], Xenopus tropicalis"
xref: Reactome:REACT_32968 "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular], Gallus gallus"
xref: Reactome:REACT_77015 "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular], Taeniopygia guttata"
xref: Reactome:REACT_77677 "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP], Sus scrofa"
xref: Reactome:REACT_79043 "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP], Taeniopygia guttata"
xref: Reactome:REACT_79527 "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP], Canis familiaris"
xref: Reactome:REACT_82556 "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP], Canis familiaris"
xref: Reactome:REACT_82838 "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular], Caenorhabditis elegans"
xref: Reactome:REACT_83371 "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP], Danio rerio"
xref: Reactome:REACT_85343 "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP], Dictyostelium discoideum"
xref: Reactome:REACT_86433 "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP], Mus musculus"
xref: Reactome:REACT_87862 "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP], Taeniopygia guttata"
xref: Reactome:REACT_87940 "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular], Sus scrofa"
xref: Reactome:REACT_89957 "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP], Caenorhabditis elegans"
xref: Reactome:REACT_90869 "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular], Canis familiaris"
xref: Reactome:REACT_90895 "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular], Danio rerio"
xref: Reactome:REACT_91766 "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP], Mus musculus"
xref: Reactome:REACT_92222 "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular], Xenopus tropicalis"
xref: Reactome:REACT_96027 "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular], Mus musculus"
xref: Reactome:REACT_99258 "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP], Sus scrofa"
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0042393
name: histone binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity." [GOC:jl]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_yeast
synonym: "histone-specific chaperone activity" RELATED []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0042394
name: obsolete ecdysis, protein-based cuticle
namespace: biological_process
def: "OBSOLETE. The shedding of the old protein-based cuticular fragments during the molting cycle. Examples of this process are found in invertebrates." [GOC:jl, GOC:mtg_sensu]
comment: This term was made obsolete because 'protein-based cuticle' is an unnecessary grouping term.
synonym: "ecdysis, protein-based cuticle" EXACT []
is_obsolete: true
consider: GO:0018990
consider: GO:0042395

[Term]
id: GO:0042395
name: ecdysis, collagen and cuticulin-based cuticle
namespace: biological_process
def: "The shedding of the old collagen and cuticulin-based cuticle fragments during the molting cycle. Examples of this process are found in invertebrates." [GOC:jl, GOC:mtg_sensu]
is_a: GO:0022404 ! molting cycle process
relationship: part_of GO:0018996 ! molting cycle, collagen and cuticulin-based cuticle

[Term]
id: GO:0042396
name: phosphagen biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phosphagen, any of a group of guanidine phosphates that occur in muscle and can be used to regenerate ATP from ADP during muscular contraction." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "phosphagen anabolism" EXACT []
synonym: "phosphagen biosynthesis" EXACT []
synonym: "phosphagen formation" EXACT []
synonym: "phosphagen synthesis" EXACT []
is_a: GO:0006599 ! phosphagen metabolic process
is_a: GO:0042398 ! cellular modified amino acid biosynthetic process
is_a: GO:0090407 ! organophosphate biosynthetic process

[Term]
id: GO:0042397
name: phosphagen catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phosphagen, any of a group of guanidine phosphates that occur in muscle and can be used to regenerate ATP from ADP during muscular contraction." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "phosphagen breakdown" EXACT []
synonym: "phosphagen catabolism" EXACT []
synonym: "phosphagen degradation" EXACT []
is_a: GO:0006599 ! phosphagen metabolic process
is_a: GO:0042219 ! cellular modified amino acid catabolic process
is_a: GO:0046434 ! organophosphate catabolic process

[Term]
id: GO:0042398
name: cellular modified amino acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents." [CHEBI:83821, GOC:ai]
subset: gosubset_prok
synonym: "amino acid derivative biosynthetic process" EXACT [GOC:curators]
synonym: "cellular amino acid derivative anabolism" EXACT []
synonym: "cellular amino acid derivative biosynthesis" EXACT []
synonym: "cellular amino acid derivative biosynthetic process" EXACT [GOC:curators]
synonym: "cellular amino acid derivative formation" EXACT []
synonym: "cellular amino acid derivative synthesis" EXACT []
synonym: "cellular modified amino acid anabolism" EXACT [GOC:mah]
synonym: "cellular modified amino acid biosynthesis" EXACT [GOC:mah]
synonym: "cellular modified amino acid formation" EXACT [GOC:mah]
synonym: "cellular modified amino acid synthesis" EXACT [GOC:mah]
is_a: GO:0006575 ! cellular modified amino acid metabolic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process

[Term]
id: GO:0042399
name: ectoine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid), a tetrahydropyrimidine commonly synthesized by halophilic bacteria." [GOC:jl, PMID:11823218]
subset: gosubset_prok
synonym: "ectoine metabolism" EXACT []
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0072527 ! pyrimidine-containing compound metabolic process

[Term]
id: GO:0042400
name: ectoine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid), a tetrahydropyrimidine commonly synthesized by halophilic bacteria." [GOC:jl, PMID:11823218]
subset: gosubset_prok
synonym: "ectoine breakdown" EXACT []
synonym: "ectoine catabolism" EXACT []
synonym: "ectoine degradation" EXACT []
is_a: GO:0042399 ! ectoine metabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:0072529 ! pyrimidine-containing compound catabolic process

[Term]
id: GO:0042401
name: cellular biogenic amine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways occurring at the level of individual cells resulting in the formation of any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters." [GOC:jl, ISBN:0395825172]
subset: gosubset_prok
synonym: "biogenic amine anabolism" EXACT []
synonym: "biogenic amine biosynthesis" EXACT []
synonym: "biogenic amine formation" EXACT []
synonym: "biogenic amine synthesis" EXACT []
is_a: GO:0006576 ! cellular biogenic amine metabolic process
is_a: GO:0009309 ! amine biosynthetic process

[Term]
id: GO:0042402
name: cellular biogenic amine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways occurring at the level of individual cells resulting in the breakdown of biogenic amines, any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters." [GOC:go_curators, GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "biogenic amine breakdown" EXACT []
synonym: "biogenic amine catabolism" EXACT []
synonym: "biogenic amine degradation" EXACT []
is_a: GO:0006576 ! cellular biogenic amine metabolic process
is_a: GO:0009310 ! amine catabolic process

[Term]
id: GO:0042403
name: thyroid hormone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine." [GOC:jl, ISBN:0198506732]
synonym: "thyroid hormone metabolism" EXACT []
is_a: GO:0006575 ! cellular modified amino acid metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0042445 ! hormone metabolic process

[Term]
id: GO:0042404
name: thyroid hormone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine." [GOC:jl, ISBN:0198506732]
synonym: "thyroid hormone breakdown" EXACT []
synonym: "thyroid hormone catabolism" EXACT []
synonym: "thyroid hormone degradation" EXACT []
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0042219 ! cellular modified amino acid catabolic process
is_a: GO:0042403 ! thyroid hormone metabolic process
is_a: GO:0042447 ! hormone catabolic process

[Term]
id: GO:0042405
name: nuclear inclusion body
namespace: cellular_component
def: "An intranuclear focus at which aggregated proteins have been sequestered." [GOC:jl]
is_a: GO:0016234 ! inclusion body
is_a: GO:0044428 ! nuclear part
intersection_of: GO:0016234 ! inclusion body
intersection_of: part_of GO:0005634 ! nucleus
relationship: part_of GO:0005634 ! nucleus

[Term]
id: GO:0042406
name: extrinsic component of endoplasmic reticulum membrane
namespace: cellular_component
def: "The component of the endoplasmic reticulum membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:curators, GOC:dos]
synonym: "extrinsic to endoplasmic reticulum membrane" NARROW []
synonym: "extrinsic to ER membrane" EXACT []
is_a: GO:0031312 ! extrinsic component of organelle membrane
is_a: GO:0044432 ! endoplasmic reticulum part
intersection_of: GO:0019898 ! extrinsic component of membrane
intersection_of: part_of GO:0005789 ! endoplasmic reticulum membrane
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane

[Term]
id: GO:0042407
name: cristae formation
namespace: biological_process
def: "The assembly of cristae, the inwards folds of the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732]
is_a: GO:0007007 ! inner mitochondrial membrane organization

[Term]
id: GO:0042408
name: obsolete myrcene/(E)-beta-ocimene synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the conversion of geranyl diphosphate (GPP) into the acyclic monoterpenes beta-myrcene, (E)-beta-ocimene, and other minor cyclic monoterpenes." [GOC:cr, PMID:10700382]
comment: This term was made obsolete because it represents two activities.
synonym: "myrcene/(E)-beta-ocimene synthase activity" EXACT []
synonym: "myrcene/ocimene synthase activity" EXACT []
xref: EC:4.6.-.-
is_obsolete: true

[Term]
id: GO:0042409
name: caffeoyl-CoA O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + caffeoyl-CoA = S-adenosyl-L-homocysteine + feruloyl-CoA." [EC:2.1.1.104]
subset: gosubset_prok
synonym: "caffeoyl coenzyme A methyltransferase activity" EXACT []
synonym: "caffeoyl-CoA 3-O-methyltransferase activity" EXACT []
synonym: "S-adenosyl-L-methionine:caffeoyl-CoA 3-O-methyltransferase activity" EXACT [EC:2.1.1.104]
synonym: "trans-caffeoyl-CoA 3-O-methyltransferase activity" EXACT [EC:2.1.1.104]
xref: EC:2.1.1.104
xref: MetaCyc:CAFFEOYL-COA-O-METHYLTRANSFERASE-RXN
xref: RHEA:16928
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0042410
name: 6-carboxyhexanoate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + CoA + pimelate = AMP + diphosphate + H(+) + pimelyl-CoA." [EC:6.2.1.14, RHEA:14784]
subset: gosubset_prok
synonym: "6-carboxyhexanoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.14]
synonym: "6-carboxyhexanoyl-CoA synthetase activity" EXACT [EC:6.2.1.14]
synonym: "pimeloyl-CoA synthetase activity" EXACT [EC:6.2.1.14]
synonym: "pimelyl-CoA synthetase activity" EXACT [EC:6.2.1.14]
xref: EC:6.2.1.14
xref: KEGG:R03209
xref: MetaCyc:6-CARBOXYHEXANOATE--COA-LIGASE-RXN
xref: RHEA:14784
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0042412
name: taurine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of taurine (2-aminoethanesulfonic acid), a sulphur-containing amino acid derivative important in the metabolism of fats." [GOC:jl, ISBN:0198600461]
subset: gosubset_prok
synonym: "taurine anabolism" EXACT []
synonym: "taurine biosynthesis" EXACT []
synonym: "taurine formation" EXACT []
synonym: "taurine synthesis" EXACT []
is_a: GO:0019530 ! taurine metabolic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process

[Term]
id: GO:0042413
name: carnitine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "carnitine breakdown" EXACT []
synonym: "carnitine catabolism" EXACT []
synonym: "carnitine degradation" EXACT []
synonym: "vitamin Bt catabolic process" EXACT []
synonym: "vitamin Bt catabolism" EXACT []
is_a: GO:0006579 ! amino-acid betaine catabolic process
is_a: GO:0009437 ! carnitine metabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:1901616 ! organic hydroxy compound catabolic process

[Term]
id: GO:0042414
name: epinephrine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine." [GOC:jl, ISBN:0192801023, ISBN:0198506732]
synonym: "adrenaline metabolic process" EXACT []
synonym: "adrenaline metabolism" EXACT []
synonym: "epinephrine metabolism" EXACT []
is_a: GO:0006584 ! catecholamine metabolic process

[Term]
id: GO:0042415
name: norepinephrine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine." [GOC:jl, ISBN:0198506732]
synonym: "levarterenol metabolic process" EXACT []
synonym: "levarterenol metabolism" EXACT []
synonym: "noradrenaline metabolic process" EXACT []
synonym: "noradrenaline metabolism" EXACT []
synonym: "norepinephrine metabolism" EXACT []
is_a: GO:0006584 ! catecholamine metabolic process

[Term]
id: GO:0042416
name: dopamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:jl, ISBN:0198506732]
synonym: "dopamine anabolism" EXACT []
synonym: "dopamine biosynthesis" EXACT []
synonym: "dopamine formation" EXACT []
synonym: "dopamine synthesis" EXACT []
is_a: GO:0042417 ! dopamine metabolic process
is_a: GO:0042423 ! catecholamine biosynthetic process

[Term]
id: GO:0042417
name: dopamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:jl, ISBN:0198506732]
synonym: "dopamine metabolism" EXACT []
is_a: GO:0006584 ! catecholamine metabolic process
is_a: GO:0097164 ! ammonium ion metabolic process

[Term]
id: GO:0042418
name: epinephrine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine." [GOC:jl, ISBN:0192801023, ISBN:0198506732]
synonym: "adrenaline biosynthesis" EXACT []
synonym: "adrenaline biosynthetic process" EXACT []
synonym: "epinephrine anabolism" EXACT []
synonym: "epinephrine biosynthesis" EXACT []
synonym: "epinephrine formation" EXACT []
synonym: "epinephrine synthesis" EXACT []
is_a: GO:0042414 ! epinephrine metabolic process
is_a: GO:0042423 ! catecholamine biosynthetic process

[Term]
id: GO:0042419
name: epinephrine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine." [GOC:jl, ISBN:0192801023, ISBN:0198506732]
synonym: "adrenaline catabolic process" EXACT []
synonym: "adrenaline catabolism" EXACT []
synonym: "epinephrine breakdown" EXACT []
synonym: "epinephrine catabolism" EXACT []
synonym: "epinephrine degradation" EXACT []
is_a: GO:0042414 ! epinephrine metabolic process
is_a: GO:0042424 ! catecholamine catabolic process

[Term]
id: GO:0042420
name: dopamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:jl, ISBN:0198506732]
synonym: "dopamine breakdown" EXACT []
synonym: "dopamine catabolism" EXACT []
synonym: "dopamine degradation" EXACT []
is_a: GO:0042417 ! dopamine metabolic process
is_a: GO:0042424 ! catecholamine catabolic process

[Term]
id: GO:0042421
name: norepinephrine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine." [GOC:jl, ISBN:0198506732]
synonym: "levarterenol biosynthesis" EXACT []
synonym: "levarterenol biosynthetic process" EXACT []
synonym: "noradrenaline biosynthesis" EXACT []
synonym: "noradrenaline biosynthetic process" EXACT []
synonym: "norepinephrine anabolism" EXACT []
synonym: "norepinephrine biosynthesis" EXACT []
synonym: "norepinephrine formation" EXACT []
synonym: "norepinephrine synthesis" EXACT []
is_a: GO:0042415 ! norepinephrine metabolic process
is_a: GO:0042423 ! catecholamine biosynthetic process

[Term]
id: GO:0042422
name: norepinephrine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine." [GOC:jl, ISBN:0198506732]
synonym: "levarterenol catabolic process" EXACT []
synonym: "levarterenol catabolism" EXACT []
synonym: "noradrenaline catabolic process" EXACT []
synonym: "noradrenaline catabolism" EXACT []
synonym: "norepinephrine breakdown" EXACT []
synonym: "norepinephrine catabolism" EXACT []
synonym: "norepinephrine degradation" EXACT []
xref: Wikipedia:Norepinephrine#Degradation
is_a: GO:0042415 ! norepinephrine metabolic process
is_a: GO:0042424 ! catecholamine catabolic process

[Term]
id: GO:0042423
name: catecholamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "catecholamine anabolism" EXACT []
synonym: "catecholamine biosynthesis" EXACT []
synonym: "catecholamine formation" EXACT []
synonym: "catecholamine synthesis" EXACT []
xref: Reactome:REACT_100398 "Catecholamine biosynthesis, Taeniopygia guttata"
xref: Reactome:REACT_100420 "Catecholamine biosynthesis, Oryza sativa"
xref: Reactome:REACT_104396 "Catecholamine biosynthesis, Bos taurus"
xref: Reactome:REACT_109053 "Catecholamine biosynthesis, Sus scrofa"
xref: Reactome:REACT_111937 "Catecholamine biosynthesis, Dictyostelium discoideum"
xref: Reactome:REACT_15551 "Catecholamine biosynthesis, Homo sapiens"
xref: Reactome:REACT_32239 "Catecholamine biosynthesis, Danio rerio"
xref: Reactome:REACT_77888 "Catecholamine biosynthesis, Caenorhabditis elegans"
xref: Reactome:REACT_78633 "Catecholamine biosynthesis, Mus musculus"
xref: Reactome:REACT_85001 "Catecholamine biosynthesis, Drosophila melanogaster"
xref: Reactome:REACT_86904 "Catecholamine biosynthesis, Rattus norvegicus"
xref: Reactome:REACT_89946 "Catecholamine biosynthesis, Arabidopsis thaliana"
xref: Reactome:REACT_91278 "Catecholamine biosynthesis, Canis familiaris"
xref: Reactome:REACT_91294 "Catecholamine biosynthesis, Xenopus tropicalis"
xref: Reactome:REACT_93395 "Catecholamine biosynthesis, Gallus gallus"
xref: Wikipedia:Catecholamines
is_a: GO:0006584 ! catecholamine metabolic process
is_a: GO:0009713 ! catechol-containing compound biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process

[Term]
id: GO:0042424
name: catecholamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "catecholamine breakdown" EXACT []
synonym: "catecholamine catabolism" EXACT []
synonym: "catecholamine degradation" EXACT []
is_a: GO:0006584 ! catecholamine metabolic process
is_a: GO:0019614 ! catechol-containing compound catabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process

[Term]
id: GO:0042425
name: choline biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine." [GOC:jl, ISBN:0192801023]
subset: gosubset_prok
synonym: "choline anabolism" EXACT []
synonym: "choline biosynthesis" EXACT []
synonym: "choline formation" EXACT []
synonym: "choline synthesis" EXACT []
xref: MetaCyc:PWY-4762
is_a: GO:0019695 ! choline metabolic process
is_a: GO:0042401 ! cellular biogenic amine biosynthetic process
is_a: GO:0046165 ! alcohol biosynthetic process

[Term]
id: GO:0042426
name: choline catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine." [GOC:jl, ISBN:0192801023]
subset: gosubset_prok
synonym: "choline breakdown" EXACT []
synonym: "choline catabolism" EXACT []
synonym: "choline degradation" EXACT []
is_a: GO:0019695 ! choline metabolic process
is_a: GO:0042402 ! cellular biogenic amine catabolic process
is_a: GO:0046164 ! alcohol catabolic process

[Term]
id: GO:0042427
name: serotonin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732]
synonym: "serotonin anabolism" EXACT []
synonym: "serotonin biosynthesis" EXACT []
synonym: "serotonin formation" EXACT []
synonym: "serotonin synthesis" EXACT []
xref: Wikipedia:Serotonin
is_a: GO:0042428 ! serotonin metabolic process
is_a: GO:0042435 ! indole-containing compound biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:1901162 ! primary amino compound biosynthetic process

[Term]
id: GO:0042428
name: serotonin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732]
synonym: "serotonin metabolism" EXACT []
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0042430 ! indole-containing compound metabolic process
is_a: GO:0097164 ! ammonium ion metabolic process
is_a: GO:1901160 ! primary amino compound metabolic process

[Term]
id: GO:0042429
name: serotonin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732]
synonym: "serotonin breakdown" EXACT []
synonym: "serotonin catabolism" EXACT []
synonym: "serotonin degradation" EXACT []
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0042428 ! serotonin metabolic process
is_a: GO:0042436 ! indole-containing compound catabolic process
is_a: GO:1901161 ! primary amino compound catabolic process

[Term]
id: GO:0042430
name: indole-containing compound metabolic process
namespace: biological_process
alt_id: GO:0042434
def: "The chemical reactions and pathways involving compounds that contain an indole (2,3-benzopyrrole) skeleton." [CHEBI:24828, GOC:jl, GOC:mah]
subset: gosubset_prok
synonym: "indole and derivative metabolic process" EXACT [GOC:curators]
synonym: "indole and derivative metabolism" EXACT []
synonym: "indole derivative metabolic process" NARROW [GOC:curators]
synonym: "indole derivative metabolism" NARROW [GOC:curators]
synonym: "indole-containing compound metabolism" EXACT [GOC:curators]
synonym: "ketole metabolic process" EXACT []
synonym: "ketole metabolism" EXACT []
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0034641 ! cellular nitrogen compound metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process

[Term]
id: GO:0042431
name: indole metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan)." [CHEBI:35581, GOC:jl]
subset: gosubset_prok
synonym: "indole metabolism" EXACT []
is_a: GO:0042430 ! indole-containing compound metabolic process

[Term]
id: GO:0042432
name: indole biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan)." [CHEBI:35581, GOC:jl]
subset: gosubset_prok
synonym: "indole anabolism" EXACT []
synonym: "indole biosynthesis" EXACT []
synonym: "indole formation" EXACT []
synonym: "indole synthesis" EXACT []
is_a: GO:0042431 ! indole metabolic process
is_a: GO:0042435 ! indole-containing compound biosynthetic process

[Term]
id: GO:0042433
name: indole catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan)." [CHEBI:35581, GOC:jl]
subset: gosubset_prok
synonym: "indole breakdown" EXACT []
synonym: "indole catabolism" EXACT []
synonym: "indole degradation" EXACT []
is_a: GO:0042431 ! indole metabolic process
is_a: GO:0042436 ! indole-containing compound catabolic process

[Term]
id: GO:0042435
name: indole-containing compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of compounds that contain an indole (2,3-benzopyrrole) skeleton." [CHEBI:24828, GOC:jl]
subset: gosubset_prok
synonym: "indole derivative biosynthesis" EXACT []
synonym: "indole derivative biosynthetic process" EXACT [GOC:curators]
synonym: "indole-containing compound anabolism" EXACT [GOC:curators]
synonym: "indole-containing compound biosynthesis" EXACT [GOC:curators]
synonym: "indole-containing compound formation" EXACT [GOC:curators]
synonym: "indole-containing compound synthesis" EXACT [GOC:curators]
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0042430 ! indole-containing compound metabolic process
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process

[Term]
id: GO:0042436
name: indole-containing compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of compounds that contain an indole (2,3-benzopyrrole) skeleton." [CHEBI:24828, GOC:jl]
subset: gosubset_prok
synonym: "indole derivative catabolic process" EXACT [GOC:curators]
synonym: "indole derivative catabolism" EXACT []
synonym: "indole-containing compound breakdown" EXACT [GOC:curators]
synonym: "indole-containing compound catabolism" EXACT [GOC:curators]
synonym: "indole-containing compound degradation" EXACT [GOC:curators]
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042430 ! indole-containing compound metabolic process
is_a: GO:0044270 ! cellular nitrogen compound catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process

[Term]
id: GO:0042437
name: indoleacetic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of indole-3-acetic acid, a compound which functions as a growth regulator in plants." [GOC:jl]
subset: gosubset_prok
synonym: "IAA catabolic process" EXACT []
synonym: "indole acetic acid catabolic process" EXACT []
synonym: "indole acetic acid catabolism" EXACT []
synonym: "indoleacetic acid breakdown" EXACT []
synonym: "indoleacetic acid catabolism" EXACT []
synonym: "indoleacetic acid degradation" EXACT []
is_a: GO:0009683 ! indoleacetic acid metabolic process
is_a: GO:0009852 ! auxin catabolic process
is_a: GO:0042436 ! indole-containing compound catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0042438
name: melanin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom." [CHEBI:25179, GOC:curators]
subset: gosubset_prok
synonym: "melanin anabolism" EXACT []
synonym: "melanin biosynthesis" EXACT []
synonym: "melanin formation" EXACT []
synonym: "melanin synthesis" EXACT []
is_a: GO:0006582 ! melanin metabolic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:0046148 ! pigment biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process

[Term]
id: GO:0042439
name: ethanolamine-containing compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ethanolamine (2-aminoethanol) and compounds derived from it." [CHEBI:16000, GOC:mah]
subset: gosubset_prok
synonym: "ethanolamine and derivative metabolic process" EXACT [GOC:curators]
synonym: "ethanolamine and derivative metabolism" EXACT []
synonym: "ethanolamine-containing compound metabolism" EXACT [GOC:mah]
is_a: GO:0006066 ! alcohol metabolic process
is_a: GO:0006576 ! cellular biogenic amine metabolic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0042440
name: pigment metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pigment, any general or particular coloring matter in living organisms, e.g. melanin." [GOC:jl, ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
synonym: "pigment metabolism" EXACT []
is_a: GO:0044710 ! single-organism metabolic process

[Term]
id: GO:0042441
name: eye pigment metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye." [GOC:ai]
synonym: "eye pigment metabolism" EXACT []
is_a: GO:0043324 ! pigment metabolic process involved in developmental pigmentation
relationship: part_of GO:0048069 ! eye pigmentation

[Term]
id: GO:0042442
name: melatonin catabolic process
namespace: biological_process
alt_id: GO:0042449
def: "The chemical reactions and pathways resulting in the breakdown of melatonin (N-acetyl-5-methoxytryptamine)." [GOC:jl]
subset: gosubset_prok
synonym: "melatonin breakdown" EXACT []
synonym: "melatonin catabolism" EXACT []
synonym: "melatonin degradation" EXACT []
is_a: GO:0030186 ! melatonin metabolic process
is_a: GO:0042436 ! indole-containing compound catabolic process
is_a: GO:0042447 ! hormone catabolic process

[Term]
id: GO:0042443
name: phenylethylamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phenylethylamine, an amine with pharmacological properties similar to those of amphetamine, occurs naturally as a neurotransmitter in the brain, and is present in chocolate and oil of bitter almonds." [GOC:jl, ISBN:0395825172]
synonym: "phenylethylamine metabolism" EXACT []
is_a: GO:0006576 ! cellular biogenic amine metabolic process
is_a: GO:0097164 ! ammonium ion metabolic process
is_a: GO:1901160 ! primary amino compound metabolic process

[Term]
id: GO:0042444
name: phenylethylamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phenylethylamine, an amine with pharmacological properties similar to those of amphetamine, occurs naturally as a neurotransmitter in the brain, and is present in chocolate and oil of bitter almonds." [GOC:jl, ISBN:0395825172]
synonym: "phenylethylamine anabolism" EXACT []
synonym: "phenylethylamine biosynthesis" EXACT []
synonym: "phenylethylamine formation" EXACT []
synonym: "phenylethylamine synthesis" EXACT []
is_a: GO:0042401 ! cellular biogenic amine biosynthetic process
is_a: GO:0042443 ! phenylethylamine metabolic process
is_a: GO:1901162 ! primary amino compound biosynthetic process

[Term]
id: GO:0042445
name: hormone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [CHEBI:24621, GOC:jl]
subset: goslim_pir
subset: gosubset_prok
synonym: "hormone metabolism" EXACT []
is_a: GO:0008152 ! metabolic process
is_a: GO:0010817 ! regulation of hormone levels

[Term]
id: GO:0042446
name: hormone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [CHEBI:24621, GOC:jl]
subset: gosubset_prok
synonym: "hormone anabolism" EXACT []
synonym: "hormone biosynthesis" EXACT []
synonym: "hormone formation" EXACT []
synonym: "hormone synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0042445 ! hormone metabolic process

[Term]
id: GO:0042447
name: hormone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [CHEBI:24621, GOC:jl]
subset: gosubset_prok
synonym: "hormone breakdown" EXACT []
synonym: "hormone catabolism" EXACT []
synonym: "hormone degradation" EXACT []
is_a: GO:0009056 ! catabolic process
is_a: GO:0042445 ! hormone metabolic process

[Term]
id: GO:0042448
name: progesterone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants." [GOC:jl, http://www.cogsci.princeton.edu/]
synonym: "progesterone metabolism" EXACT []
is_a: GO:0008207 ! C21-steroid hormone metabolic process
is_a: GO:0042180 ! cellular ketone metabolic process

[Term]
id: GO:0042450
name: arginine biosynthetic process via ornithine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound ornithine." [GOC:jl]
subset: gosubset_prok
synonym: "arginine anabolism via ornithine" EXACT []
synonym: "arginine formation via ornithine" EXACT []
synonym: "arginine synthesis via ornithine" EXACT []
is_a: GO:0006526 ! arginine biosynthetic process
is_a: GO:0006591 ! ornithine metabolic process

[Term]
id: GO:0042451
name: purine nucleoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:go_curators]
subset: gosubset_prok
synonym: "purine nucleoside anabolism" EXACT []
synonym: "purine nucleoside biosynthesis" EXACT []
synonym: "purine nucleoside formation" EXACT []
synonym: "purine nucleoside synthesis" EXACT []
is_a: GO:0009163 ! nucleoside biosynthetic process
is_a: GO:0042278 ! purine nucleoside metabolic process
is_a: GO:0072522 ! purine-containing compound biosynthetic process

[Term]
id: GO:0042452
name: deoxyguanosine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of deoxyguanosine, a nucleoside consisting of the base guanine and the sugar deoxyribose." [CHEBI:17172, GOC:jl]
subset: gosubset_prok
synonym: "deoxyguanosine anabolism" EXACT []
synonym: "deoxyguanosine biosynthesis" EXACT []
synonym: "deoxyguanosine formation" EXACT []
synonym: "deoxyguanosine synthesis" EXACT []
is_a: GO:0042453 ! deoxyguanosine metabolic process
is_a: GO:0046123 ! purine deoxyribonucleoside biosynthetic process

[Term]
id: GO:0042453
name: deoxyguanosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving deoxyguanosine, a nucleoside consisting of the base guanine and the sugar deoxyribose." [CHEBI:17172, GOC:jl]
subset: gosubset_prok
synonym: "deoxyguanosine metabolism" EXACT []
is_a: GO:0046122 ! purine deoxyribonucleoside metabolic process

[Term]
id: GO:0042454
name: ribonucleoside catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule." [CHEBI:18254, GOC:jl]
subset: gosubset_prok
synonym: "ribonucleoside breakdown" EXACT []
synonym: "ribonucleoside catabolism" EXACT []
synonym: "ribonucleoside degradation" EXACT []
is_a: GO:0009119 ! ribonucleoside metabolic process
is_a: GO:0009164 ! nucleoside catabolic process

[Term]
id: GO:0042455
name: ribonucleoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule." [CHEBI:18254, GOC:jl]
subset: gosubset_prok
synonym: "ribonucleoside anabolism" EXACT []
synonym: "ribonucleoside biosynthesis" EXACT []
synonym: "ribonucleoside formation" EXACT []
synonym: "ribonucleoside synthesis" EXACT []
is_a: GO:0009119 ! ribonucleoside metabolic process
is_a: GO:0009163 ! nucleoside biosynthetic process

[Term]
id: GO:0042457
name: ethylene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator." [GOC:jl, ISBN:0387969845]
subset: gosubset_prok
synonym: "ethene catabolic process" EXACT []
synonym: "ethene catabolism" EXACT []
synonym: "ethylene breakdown" EXACT []
synonym: "ethylene catabolism" EXACT []
synonym: "ethylene degradation" EXACT []
is_a: GO:0009692 ! ethylene metabolic process
is_a: GO:0043451 ! alkene catabolic process

[Term]
id: GO:0042458
name: nopaline catabolic process to proline
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of nopaline into other compounds, including proline." [GOC:go_curators]
subset: gosubset_prok
synonym: "nopaline breakdown to proline" EXACT []
synonym: "nopaline degradation to proline" EXACT []
xref: MetaCyc:NOPALINEDEG-PWY
is_a: GO:0006560 ! proline metabolic process
is_a: GO:0019468 ! nopaline catabolic process

[Term]
id: GO:0042459
name: octopine catabolic process to proline
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of octopine into other compounds, including proline." [GOC:go_curators]
subset: gosubset_prok
synonym: "octopine breakdown to proline" EXACT []
synonym: "octopine degradation to proline" EXACT []
xref: MetaCyc:OCTOPINEDEG-PWY
is_a: GO:0006560 ! proline metabolic process
is_a: GO:0019469 ! octopine catabolic process

[Term]
id: GO:0042461
name: photoreceptor cell development
namespace: biological_process
alt_id: GO:0046531
def: "Development of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light." [GOC:go_curators]
synonym: "photoreceptor morphogenesis" EXACT []
is_a: GO:0048666 ! neuron development
relationship: part_of GO:0046530 ! photoreceptor cell differentiation

[Term]
id: GO:0042462
name: eye photoreceptor cell development
namespace: biological_process
def: "Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve." [GOC:jl, ISBN:0192800981]
is_a: GO:0042461 ! photoreceptor cell development
relationship: part_of GO:0001754 ! eye photoreceptor cell differentiation

[Term]
id: GO:0042463
name: ocellus photoreceptor cell development
namespace: biological_process
alt_id: GO:0001749
def: "Development of photoreceptors, sensory cells that react to the presence of light, found in the ocellus." [GOC:jl, ISBN:0192800981, PMID:11542766]
synonym: "non-eye photoreceptor development" BROAD []
is_a: GO:0042461 ! photoreceptor cell development
relationship: part_of GO:0042705 ! ocellus photoreceptor cell differentiation

[Term]
id: GO:0042464
name: dosage compensation by hypoactivation of X chromosome
namespace: biological_process
def: "Compensating for the two-fold variation in X:autosome chromosome ratios between sexes by an inactivation of a proportion of genes on both of the X chromosomes of the XX sex, leading to a decrease, of half, of the levels of gene expression from these chromosomes. An example of this process is found in Caenorhabditis elegans." [GOC:jl, PMID:11102361]
is_a: GO:0007549 ! dosage compensation

[Term]
id: GO:0042465
name: kinesis
namespace: biological_process
def: "The movement of a cell or organism in response to a stimulus in which the rate of movement depends on the intensity (rather than the direction) of the stimulus." [GOC:jl, ISBN:0192801023]
xref: Wikipedia:Kinesis
is_a: GO:0009605 ! response to external stimulus

[Term]
id: GO:0042466
name: chemokinesis
namespace: biological_process
def: "A response by a motile cell to a soluble chemical that involves an increase or decrease in speed (positive or negative orthokinesis) or of frequency of movement or a change in the frequency or magnitude of turning behavior (klinokinesis)." [GOC:jl, PMID:2073411]
xref: Wikipedia:Chemokinesis
is_a: GO:0042465 ! kinesis

[Term]
id: GO:0042467
name: orthokinesis
namespace: biological_process
def: "The movement of a cell or organism in response to a stimulus in which the speed or frequency of movement is increased or decreased." [GOC:jl, PMID:8207088]
is_a: GO:0042465 ! kinesis

[Term]
id: GO:0042468
name: klinokinesis
namespace: biological_process
def: "The movement of a cell or organism in response to a stimulus in which the frequency or magnitude of turning behavior is altered." [GOC:jl, PMID:2790068]
is_a: GO:0042465 ! kinesis

[Term]
id: GO:0042469
name: versicolorin reductase activity
namespace: molecular_function
def: "Catalysis of the reduction of versicolorin A to sterigmatocystin." [PMID:1339261]
xref: EC:1.1.-.-
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0042470
name: melanosome
namespace: cellular_component
def: "A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells." [GOC:jl, PMID:11584301]
xref: Wikipedia:Melanosome
is_a: GO:0048770 ! pigment granule

[Term]
id: GO:0042471
name: ear morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the ear are generated and organized. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals." [GOC:jl, ISBN:0192801023]
synonym: "hearing organ morphogenesis" EXACT []
is_a: GO:0048562 ! embryonic organ morphogenesis
is_a: GO:0090596 ! sensory organ morphogenesis
relationship: part_of GO:0043583 ! ear development

[Term]
id: GO:0042472
name: inner ear morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively." [GOC:jl, ISBN:0192801023]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0042471 ! ear morphogenesis
relationship: part_of GO:0048839 ! inner ear development

[Term]
id: GO:0042473
name: outer ear morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the outer ear are generated and organized. The outer ear is the part of the ear external to the tympanum (eardrum). It consists of a tube (the external auditory meatus) that directs sound waves on to the tympanum, and may also include the external pinna, which extends beyond the skull." [GOC:jl, ISBN:0192801023]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0042471 ! ear morphogenesis

[Term]
id: GO:0042474
name: middle ear morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the middle ear are generated and organized. The middle ear is the air-filled cavity within the skull of vertebrates that lies between the outer ear and the inner ear. It is linked to the pharynx (and therefore to outside air) via the Eustachian tube and in mammals contains the three ear ossicles, which transmit auditory vibrations from the outer ear (via the tympanum) to the inner ear (via the oval window)." [GOC:jl, ISBN:0192801023]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0042471 ! ear morphogenesis

[Term]
id: GO:0042475
name: odontogenesis of dentin-containing tooth
namespace: biological_process
def: "The process whose specific outcome is the progression of a dentin-containing tooth over time, from its formation to the mature structure. A dentin-containing tooth is a hard, bony organ borne on the jaw or other bone of a vertebrate, and is composed mainly of dentin, a dense calcified substance, covered by a layer of enamel." [GOC:cjm, GOC:mah, GOC:mtg_sensu, PMID:10333884, PMID:15355794]
comment: Note that placoid scales found in the cartilaginous fishes presumably develop through the same processes, but are found on the dermis, rather than in the mouth or pharynx. See http://en.wikipedia.org/wiki/Placoid_scale#Placoid_scales.
synonym: "odontogenesis of dentine-containing teeth" EXACT []
synonym: "odontogenesis of dentine-containing tooth" EXACT [GOC:mah]
synonym: "odontogeny" BROAD []
synonym: "odontosis" BROAD []
synonym: "tooth development" BROAD []
is_a: GO:0042476 ! odontogenesis

[Term]
id: GO:0042476
name: odontogenesis
namespace: biological_process
alt_id: GO:0042477
def: "The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food." [GOC:jl, GOC:mah]
synonym: "odontogenesis of calcareous or chitinous tooth" NARROW []
synonym: "odontogeny" EXACT []
synonym: "odontosis" EXACT []
synonym: "tooth development" RELATED []
synonym: "tooth morphogenesis" EXACT []
xref: Wikipedia:Odontogenesis
is_a: GO:0009887 ! organ morphogenesis

[Term]
id: GO:0042478
name: regulation of eye photoreceptor cell development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of eye photoreceptor development." [GOC:jl]
synonym: "regulation of eye photoreceptor development" EXACT []
is_a: GO:0046532 ! regulation of photoreceptor cell differentiation
is_a: GO:2000027 ! regulation of organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042462 ! eye photoreceptor cell development
relationship: regulates GO:0042462 ! eye photoreceptor cell development

[Term]
id: GO:0042479
name: positive regulation of eye photoreceptor cell development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of eye photoreceptor development." [GOC:jl]
synonym: "activation of eye photoreceptor cell development" NARROW []
synonym: "positive regulation of eye photoreceptor development" EXACT []
synonym: "stimulation of eye photoreceptor cell development" NARROW []
synonym: "up regulation of eye photoreceptor cell development" EXACT []
synonym: "up-regulation of eye photoreceptor cell development" EXACT []
synonym: "upregulation of eye photoreceptor cell development" EXACT []
is_a: GO:0042478 ! regulation of eye photoreceptor cell development
is_a: GO:0046534 ! positive regulation of photoreceptor cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042462 ! eye photoreceptor cell development
relationship: positively_regulates GO:0042462 ! eye photoreceptor cell development

[Term]
id: GO:0042480
name: negative regulation of eye photoreceptor cell development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of eye photoreceptor development." [GOC:jl]
synonym: "down regulation of eye photoreceptor cell development" EXACT []
synonym: "down-regulation of eye photoreceptor cell development" EXACT []
synonym: "downregulation of eye photoreceptor cell development" EXACT []
synonym: "inhibition of eye photoreceptor cell development" NARROW []
synonym: "negative regulation of eye photoreceptor development" EXACT []
is_a: GO:0042478 ! regulation of eye photoreceptor cell development
is_a: GO:0046533 ! negative regulation of photoreceptor cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042462 ! eye photoreceptor cell development
relationship: negatively_regulates GO:0042462 ! eye photoreceptor cell development

[Term]
id: GO:0042481
name: regulation of odontogenesis
namespace: biological_process
alt_id: GO:0042484
def: "Any process that modulates the frequency, rate or extent of the formation and development of a tooth or teeth." [GOC:jl]
synonym: "regulation of odontogenesis of calcareous or chitinous tooth" NARROW []
synonym: "regulation of tooth development" EXACT []
is_a: GO:2000027 ! regulation of organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042476 ! odontogenesis
relationship: regulates GO:0042476 ! odontogenesis

[Term]
id: GO:0042482
name: positive regulation of odontogenesis
namespace: biological_process
alt_id: GO:0042485
def: "Any process that activates or increases the frequency, rate or extent of the formation and development of a tooth or teeth." [GOC:jl]
synonym: "activation of odontogenesis" NARROW []
synonym: "positive regulation of odontogenesis of calcareous or chitinous tooth" NARROW []
synonym: "positive regulation of tooth development" EXACT []
synonym: "stimulation of odontogenesis" NARROW []
synonym: "up regulation of odontogenesis" EXACT []
synonym: "up-regulation of odontogenesis" EXACT []
synonym: "upregulation of odontogenesis" EXACT []
is_a: GO:0042481 ! regulation of odontogenesis
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042476 ! odontogenesis
relationship: positively_regulates GO:0042476 ! odontogenesis

[Term]
id: GO:0042483
name: negative regulation of odontogenesis
namespace: biological_process
alt_id: GO:0042486
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation and development of a tooth or teeth." [GOC:jl]
synonym: "down regulation of odontogenesis" EXACT []
synonym: "down-regulation of odontogenesis" EXACT []
synonym: "downregulation of odontogenesis" EXACT []
synonym: "inhibition of odontogenesis" NARROW []
synonym: "negative regulation of odontogenesis of calcareous or chitinous tooth" NARROW []
synonym: "negative regulation of tooth development" EXACT []
is_a: GO:0042481 ! regulation of odontogenesis
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042476 ! odontogenesis
relationship: negatively_regulates GO:0042476 ! odontogenesis

[Term]
id: GO:0042487
name: regulation of odontogenesis of dentin-containing tooth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates." [GOC:jl, GOC:mtg_sensu, PMID:15355794]
synonym: "regulation of odontogenesis of dentine-containing teeth" EXACT []
synonym: "regulation of odontogenesis of dentine-containing tooth" EXACT [GOC:mah]
is_a: GO:0042481 ! regulation of odontogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042475 ! odontogenesis of dentin-containing tooth
relationship: regulates GO:0042475 ! odontogenesis of dentin-containing tooth

[Term]
id: GO:0042488
name: positive regulation of odontogenesis of dentin-containing tooth
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages that are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates." [dictyBase_REF:2530, GOC:jl, PMID:15355794]
synonym: "activation of odontogenesis" BROAD []
synonym: "positive regulation of odontogenesis of dentine-containing teeth" EXACT []
synonym: "positive regulation of odontogenesis of dentine-containing tooth" RELATED []
synonym: "stimulation of odontogenesis" BROAD []
synonym: "up regulation of odontogenesis" BROAD []
synonym: "up-regulation of odontogenesis" BROAD []
synonym: "upregulation of odontogenesis" BROAD []
is_a: GO:0042482 ! positive regulation of odontogenesis
is_a: GO:0042487 ! regulation of odontogenesis of dentin-containing tooth
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042475 ! odontogenesis of dentin-containing tooth
relationship: positively_regulates GO:0042475 ! odontogenesis of dentin-containing tooth

[Term]
id: GO:0042489
name: negative regulation of odontogenesis of dentin-containing tooth
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx." [GOC:jl, GOC:mtg_sensu, PMID:15355794]
synonym: "down regulation of odontogenesis" BROAD []
synonym: "down-regulation of odontogenesis" BROAD []
synonym: "downregulation of odontogenesis" BROAD []
synonym: "inhibition of odontogenesis" BROAD []
synonym: "negative regulation of odontogenesis" BROAD []
synonym: "negative regulation of odontogenesis of dentine-containing teeth" EXACT []
synonym: "negative regulation of odontogenesis of dentine-containing tooth" RELATED []
is_a: GO:0042483 ! negative regulation of odontogenesis
is_a: GO:0042487 ! regulation of odontogenesis of dentin-containing tooth
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042475 ! odontogenesis of dentin-containing tooth
relationship: negatively_regulates GO:0042475 ! odontogenesis of dentin-containing tooth

[Term]
id: GO:0042490
name: mechanoreceptor differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a mechanoreceptor, a cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system." [CL:0000199, GOC:jl]
is_a: GO:0030182 ! neuron differentiation

[Term]
id: GO:0042491
name: auditory receptor cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an auditory hair cell." [CL:0000201, GOC:jl]
comment: Note that this term refers to the mechanosensory hair cells of the inner ear.
synonym: "auditory hair cell differentiation" EXACT []
is_a: GO:0035315 ! hair cell differentiation
is_a: GO:0060113 ! inner ear receptor cell differentiation
is_a: GO:0060563 ! neuroepithelial cell differentiation

[Term]
id: GO:0042492
name: gamma-delta T cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized hemopoietic cell acquires specialized features of a gamma-delta T cell. A gamma-delta T cell is a T cell that expresses a gamma-delta T cell receptor complex." [CL:0000798, GOC:jl]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "gamma-delta T cell development" RELATED [GOC:add]
synonym: "gamma-delta T lymphocyte differentiation" EXACT []
synonym: "gamma-delta T-cell differentiation" EXACT []
synonym: "gamma-delta T-lymphocyte differentiation" EXACT []
is_a: GO:0030217 ! T cell differentiation
is_a: GO:0046629 ! gamma-delta T cell activation

[Term]
id: GO:0042493
name: response to drug
namespace: biological_process
alt_id: GO:0017035
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease." [GOC:jl]
subset: goslim_candida
subset: gosubset_prok
synonym: "drug resistance" RELATED []
synonym: "drug susceptibility/resistance" RELATED []
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0042494
name: detection of bacterial lipoprotein
namespace: biological_process
def: "The series of events in which a bacterial lipoprotein stimulus is received by a cell and converted into a molecular signal. Bacterial lipoproteins are lipoproteins characterized by the presence of conserved sequence motifs called pathogen-associated molecular patterns (PAMPs)." [GOC:jl, PMID:12077222]
synonym: "detection of BLP" RELATED []
synonym: "detection of Lpp" RELATED []
synonym: "perception of bacterial lipoprotein" RELATED []
synonym: "perception of BLP" RELATED []
synonym: "perception of Lpp" RELATED []
is_a: GO:0032490 ! detection of molecule of bacterial origin
is_a: GO:0032493 ! response to bacterial lipoprotein
relationship: part_of GO:0016045 ! detection of bacterium

[Term]
id: GO:0042495
name: detection of triacyl bacterial lipopeptide
namespace: biological_process
def: "The series of events in which a triacylated bacterial lipoprotein stimulus is received by a cell and converted into a molecular signal. Triacylated bacterial lipoproteins are lipopeptides of bacterial origin containing a nonprotein moiety consisting of three acyl groups." [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794]
comment: Note that bacterial lipopeptides are derived from bacterial lipoproteins, but the two terms are sometimes used interchangeably in the literature.
synonym: "detection of triacylated bacterial lipoprotein" EXACT [GOC:add]
synonym: "perception of triacylated bacterial lipopeptide" RELATED [GOC:add]
synonym: "perception of triacylated bacterial lipoprotein" RELATED [GOC:curators]
is_a: GO:0070340 ! detection of bacterial lipopeptide
is_a: GO:0071725 ! response to triacyl bacterial lipopeptide

[Term]
id: GO:0042496
name: detection of diacyl bacterial lipopeptide
namespace: biological_process
def: "The series of events in which a diacylated bacterial lipopeptide stimulus is received by a cell and converted into a molecular signal. Diacylated bacterial lipoproteins are lipopeptides of bacterial origin containing a nonprotein moiety consisting of two acyl groups." [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794]
comment: Note that bacterial lipopeptides are derived from bacterial lipoproteins, but the two terms are sometimes used interchangeably in the literature.
synonym: "detection of diacylated bacterial lipoprotein" EXACT [GOC:add]
synonym: "perception of diacylated bacterial lipopeptide" RELATED [GOC:add]
synonym: "perception of diacylated bacterial lipoprotein" RELATED [GOC:curators]
is_a: GO:0070340 ! detection of bacterial lipopeptide
is_a: GO:0071724 ! response to diacyl bacterial lipopeptide

[Term]
id: GO:0042497
name: triacyl lipopeptide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a lipopeptide containing a nonprotein moiety consisting of three acyl groups." [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794]
comment: Note that bacterial lipopeptides are derived from bacterial lipoproteins, but the two terms are sometimes used interchangeably in the literature.
synonym: "bacterial triacyl lipopeptide binding" NARROW [GOC:add]
synonym: "bacterial triacyl lipoprotein binding" RELATED [GOC:add]
synonym: "triacylated lipopeptide binding" EXACT []
is_a: GO:0071723 ! lipopeptide binding

[Term]
id: GO:0042498
name: diacyl lipopeptide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a lipopeptide containing a nonprotein moiety consisting of two acyl groups." [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794]
comment: Note that bacterial lipopeptides are derived from bacterial lipoproteins, but the two terms are sometimes used interchangeably in the literature.
synonym: "bacterial diacyl lipopeptide binding" NARROW [GOC:add]
synonym: "bacterial diacyl lipoprotein binding" RELATED [GOC:add]
synonym: "diacylated lipopeptide binding" EXACT []
is_a: GO:0071723 ! lipopeptide binding

[Term]
id: GO:0042499
name: obsolete signal peptide peptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the intramembrane proteolysis of a signal peptide, following its removal from a preprotein." [PMID:12077416]
comment: This term was made obsolete because it represents a gene product.
synonym: "signal peptide peptidase activity" EXACT []
synonym: "SPP" EXACT []
xref: EC:3.4.23.-
is_obsolete: true
replaced_by: GO:0042500

[Term]
id: GO:0042500
name: aspartic endopeptidase activity, intramembrane cleaving
namespace: molecular_function
def: "Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within a membrane." [GOC:jl, ISBN:0198506732]
comment: Note that although GO generally avoids the use of localization information in terms, in this case an exception was made. This is because the fact that the cleavage occurs within the membrane is integral to its function, as it is the only thing that distinguishes this group from other aspartic endopeptidases.
xref: EC:3.4.23.-
is_a: GO:0004190 ! aspartic-type endopeptidase activity

[Term]
id: GO:0042501
name: serine phosphorylation of STAT protein
namespace: biological_process
def: "The process of introducing a phosphate group to a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:jl, PMID:10918594]
is_a: GO:0018105 ! peptidyl-serine phosphorylation
relationship: part_of GO:0046425 ! regulation of JAK-STAT cascade

[Term]
id: GO:0042502
name: tyrosine phosphorylation of Stat2 protein
namespace: biological_process
def: "The process of introducing a phosphate group to a tyrosine residue of a Stat2 protein." [GOC:jl, PMID:10918594]
is_a: GO:0007260 ! tyrosine phosphorylation of STAT protein

[Term]
id: GO:0042503
name: tyrosine phosphorylation of Stat3 protein
namespace: biological_process
def: "The process of introducing a phosphate group to a tyrosine residue of a Stat3 protein." [GOC:jl, PMID:11426647]
is_a: GO:0007260 ! tyrosine phosphorylation of STAT protein

[Term]
id: GO:0042504
name: tyrosine phosphorylation of Stat4 protein
namespace: biological_process
def: "The process of introducing a phosphate group to a tyrosine residue of a Stat4 protein." [GOC:jl, PMID:11426647]
is_a: GO:0007260 ! tyrosine phosphorylation of STAT protein

[Term]
id: GO:0042505
name: tyrosine phosphorylation of Stat6 protein
namespace: biological_process
def: "The process of introducing a phosphate group to a tyrosine residue of a Stat6 protein." [GOC:jl, PMID:11426647]
is_a: GO:0007260 ! tyrosine phosphorylation of STAT protein

[Term]
id: GO:0042506
name: tyrosine phosphorylation of Stat5 protein
namespace: biological_process
def: "The process of introducing a phosphate group to a tyrosine residue of a Stat5 protein." [GOC:jl, PMID:11426647]
is_a: GO:0007260 ! tyrosine phosphorylation of STAT protein

[Term]
id: GO:0042507
name: tyrosine phosphorylation of Stat7 protein
namespace: biological_process
def: "The process of introducing a phosphate group to a tyrosine residue of a Stat7 protein." [GOC:jl, PMID:11426647]
is_a: GO:0007260 ! tyrosine phosphorylation of STAT protein

[Term]
id: GO:0042508
name: tyrosine phosphorylation of Stat1 protein
namespace: biological_process
def: "The process of introducing a phosphate group to a tyrosine residue of a Stat1 protein." [GOC:jl, PMID:10918594]
is_a: GO:0007260 ! tyrosine phosphorylation of STAT protein

[Term]
id: GO:0042509
name: regulation of tyrosine phosphorylation of STAT protein
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:jl, PMID:11426647]
is_a: GO:0046425 ! regulation of JAK-STAT cascade
is_a: GO:0050730 ! regulation of peptidyl-tyrosine phosphorylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007260 ! tyrosine phosphorylation of STAT protein
relationship: regulates GO:0007260 ! tyrosine phosphorylation of STAT protein

[Term]
id: GO:0042510
name: regulation of tyrosine phosphorylation of Stat1 protein
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat1 protein." [GOC:jl, PMID:10918594]
is_a: GO:0042509 ! regulation of tyrosine phosphorylation of STAT protein
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042508 ! tyrosine phosphorylation of Stat1 protein
relationship: regulates GO:0042508 ! tyrosine phosphorylation of Stat1 protein

[Term]
id: GO:0042511
name: positive regulation of tyrosine phosphorylation of Stat1 protein
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat1 protein." [GOC:jl, PMID:10918594]
synonym: "activation of tyrosine phosphorylation of Stat1 protein" NARROW []
synonym: "stimulation of tyrosine phosphorylation of Stat1 protein" NARROW []
synonym: "up regulation of tyrosine phosphorylation of Stat1 protein" EXACT []
synonym: "up-regulation of tyrosine phosphorylation of Stat1 protein" EXACT []
synonym: "upregulation of tyrosine phosphorylation of Stat1 protein" EXACT []
is_a: GO:0042510 ! regulation of tyrosine phosphorylation of Stat1 protein
is_a: GO:0042531 ! positive regulation of tyrosine phosphorylation of STAT protein
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042508 ! tyrosine phosphorylation of Stat1 protein
relationship: positively_regulates GO:0042508 ! tyrosine phosphorylation of Stat1 protein

[Term]
id: GO:0042512
name: negative regulation of tyrosine phosphorylation of Stat1 protein
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat1 protein." [GOC:jl, PMID:10918594]
synonym: "down regulation of tyrosine phosphorylation of Stat1 protein" EXACT []
synonym: "down-regulation of tyrosine phosphorylation of Stat1 protein" EXACT []
synonym: "downregulation of tyrosine phosphorylation of Stat1 protein" EXACT []
synonym: "inhibition of tyrosine phosphorylation of Stat1 protein" NARROW []
is_a: GO:0042510 ! regulation of tyrosine phosphorylation of Stat1 protein
is_a: GO:0042532 ! negative regulation of tyrosine phosphorylation of STAT protein
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042508 ! tyrosine phosphorylation of Stat1 protein
relationship: negatively_regulates GO:0042508 ! tyrosine phosphorylation of Stat1 protein

[Term]
id: GO:0042513
name: regulation of tyrosine phosphorylation of Stat2 protein
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat2 protein." [GOC:jl, PMID:10918594]
is_a: GO:0042509 ! regulation of tyrosine phosphorylation of STAT protein
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042502 ! tyrosine phosphorylation of Stat2 protein
relationship: regulates GO:0042502 ! tyrosine phosphorylation of Stat2 protein

[Term]
id: GO:0042514
name: negative regulation of tyrosine phosphorylation of Stat2 protein
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat2 protein." [GOC:jl, PMID:10918594]
synonym: "down regulation of tyrosine phosphorylation of Stat2 protein" EXACT []
synonym: "down-regulation of tyrosine phosphorylation of Stat2 protein" EXACT []
synonym: "downregulation of tyrosine phosphorylation of Stat2 protein" EXACT []
synonym: "inhibition of tyrosine phosphorylation of Stat2 protein" NARROW []
is_a: GO:0042513 ! regulation of tyrosine phosphorylation of Stat2 protein
is_a: GO:0042532 ! negative regulation of tyrosine phosphorylation of STAT protein
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042502 ! tyrosine phosphorylation of Stat2 protein
relationship: negatively_regulates GO:0042502 ! tyrosine phosphorylation of Stat2 protein

[Term]
id: GO:0042515
name: positive regulation of tyrosine phosphorylation of Stat2 protein
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat2 protein." [GOC:jl, PMID:10918594]
synonym: "activation of tyrosine phosphorylation of Stat2 protein" NARROW []
synonym: "stimulation of tyrosine phosphorylation of Stat2 protein" NARROW []
synonym: "up regulation of tyrosine phosphorylation of Stat2 protein" EXACT []
synonym: "up-regulation of tyrosine phosphorylation of Stat2 protein" EXACT []
synonym: "upregulation of tyrosine phosphorylation of Stat2 protein" EXACT []
is_a: GO:0042513 ! regulation of tyrosine phosphorylation of Stat2 protein
is_a: GO:0042531 ! positive regulation of tyrosine phosphorylation of STAT protein
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042502 ! tyrosine phosphorylation of Stat2 protein
relationship: positively_regulates GO:0042502 ! tyrosine phosphorylation of Stat2 protein

[Term]
id: GO:0042516
name: regulation of tyrosine phosphorylation of Stat3 protein
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat3 protein." [GOC:jl, PMID:11426647]
is_a: GO:0042509 ! regulation of tyrosine phosphorylation of STAT protein
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042503 ! tyrosine phosphorylation of Stat3 protein
relationship: regulates GO:0042503 ! tyrosine phosphorylation of Stat3 protein

[Term]
id: GO:0042517
name: positive regulation of tyrosine phosphorylation of Stat3 protein
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat3 protein." [GOC:jl, PMID:11426647]
synonym: "activation of tyrosine phosphorylation of Stat3 protein" NARROW []
synonym: "stimulation of tyrosine phosphorylation of Stat3 protein" NARROW []
synonym: "up regulation of tyrosine phosphorylation of Stat3 protein" EXACT []
synonym: "up-regulation of tyrosine phosphorylation of Stat3 protein" EXACT []
synonym: "upregulation of tyrosine phosphorylation of Stat3 protein" EXACT []
is_a: GO:0042516 ! regulation of tyrosine phosphorylation of Stat3 protein
is_a: GO:0042531 ! positive regulation of tyrosine phosphorylation of STAT protein
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042503 ! tyrosine phosphorylation of Stat3 protein
relationship: positively_regulates GO:0042503 ! tyrosine phosphorylation of Stat3 protein

[Term]
id: GO:0042518
name: negative regulation of tyrosine phosphorylation of Stat3 protein
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat3 protein." [GOC:jl, PMID:11426647]
synonym: "down regulation of tyrosine phosphorylation of Stat3 protein" EXACT []
synonym: "down-regulation of tyrosine phosphorylation of Stat3 protein" EXACT []
synonym: "downregulation of tyrosine phosphorylation of Stat3 protein" EXACT []
synonym: "inhibition of tyrosine phosphorylation of Stat3 protein" NARROW []
is_a: GO:0042516 ! regulation of tyrosine phosphorylation of Stat3 protein
is_a: GO:0042532 ! negative regulation of tyrosine phosphorylation of STAT protein
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042503 ! tyrosine phosphorylation of Stat3 protein
relationship: negatively_regulates GO:0042503 ! tyrosine phosphorylation of Stat3 protein

[Term]
id: GO:0042519
name: regulation of tyrosine phosphorylation of Stat4 protein
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat4 protein." [GOC:jl, PMID:11426647]
is_a: GO:0042509 ! regulation of tyrosine phosphorylation of STAT protein
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042504 ! tyrosine phosphorylation of Stat4 protein
relationship: regulates GO:0042504 ! tyrosine phosphorylation of Stat4 protein

[Term]
id: GO:0042520
name: positive regulation of tyrosine phosphorylation of Stat4 protein
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat4 protein." [GOC:jl, PMID:11426647]
synonym: "activation of tyrosine phosphorylation of Stat4 protein" NARROW []
synonym: "stimulation of tyrosine phosphorylation of Stat4 protein" NARROW []
synonym: "up regulation of tyrosine phosphorylation of Stat4 protein" EXACT []
synonym: "up-regulation of tyrosine phosphorylation of Stat4 protein" EXACT []
synonym: "upregulation of tyrosine phosphorylation of Stat4 protein" EXACT []
is_a: GO:0042519 ! regulation of tyrosine phosphorylation of Stat4 protein
is_a: GO:0042531 ! positive regulation of tyrosine phosphorylation of STAT protein
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042504 ! tyrosine phosphorylation of Stat4 protein
relationship: positively_regulates GO:0042504 ! tyrosine phosphorylation of Stat4 protein

[Term]
id: GO:0042521
name: negative regulation of tyrosine phosphorylation of Stat4 protein
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat4 protein." [GOC:jl, PMID:11426647]
synonym: "down regulation of tyrosine phosphorylation of Stat4 protein" EXACT []
synonym: "down-regulation of tyrosine phosphorylation of Stat4 protein" EXACT []
synonym: "downregulation of tyrosine phosphorylation of Stat4 protein" EXACT []
synonym: "inhibition of tyrosine phosphorylation of Stat4 protein" NARROW []
is_a: GO:0042519 ! regulation of tyrosine phosphorylation of Stat4 protein
is_a: GO:0042532 ! negative regulation of tyrosine phosphorylation of STAT protein
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042504 ! tyrosine phosphorylation of Stat4 protein
relationship: negatively_regulates GO:0042504 ! tyrosine phosphorylation of Stat4 protein

[Term]
id: GO:0042522
name: regulation of tyrosine phosphorylation of Stat5 protein
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat5 protein." [GOC:jl, PMID:11426647]
is_a: GO:0042509 ! regulation of tyrosine phosphorylation of STAT protein
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042506 ! tyrosine phosphorylation of Stat5 protein
relationship: regulates GO:0042506 ! tyrosine phosphorylation of Stat5 protein

[Term]
id: GO:0042523
name: positive regulation of tyrosine phosphorylation of Stat5 protein
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat5 protein." [GOC:jl, PMID:11426647]
synonym: "activation of tyrosine phosphorylation of Stat5 protein" NARROW []
synonym: "stimulation of tyrosine phosphorylation of Stat5 protein" NARROW []
synonym: "up regulation of tyrosine phosphorylation of Stat5 protein" EXACT []
synonym: "up-regulation of tyrosine phosphorylation of Stat5 protein" EXACT []
synonym: "upregulation of tyrosine phosphorylation of Stat5 protein" EXACT []
is_a: GO:0042522 ! regulation of tyrosine phosphorylation of Stat5 protein
is_a: GO:0042531 ! positive regulation of tyrosine phosphorylation of STAT protein
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042506 ! tyrosine phosphorylation of Stat5 protein
relationship: positively_regulates GO:0042506 ! tyrosine phosphorylation of Stat5 protein

[Term]
id: GO:0042524
name: negative regulation of tyrosine phosphorylation of Stat5 protein
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat5 protein." [GOC:jl, PMID:11426647]
synonym: "down regulation of tyrosine phosphorylation of Stat5 protein" EXACT []
synonym: "down-regulation of tyrosine phosphorylation of Stat5 protein" EXACT []
synonym: "downregulation of tyrosine phosphorylation of Stat5 protein" EXACT []
synonym: "inhibition of tyrosine phosphorylation of Stat5 protein" NARROW []
is_a: GO:0042522 ! regulation of tyrosine phosphorylation of Stat5 protein
is_a: GO:0042532 ! negative regulation of tyrosine phosphorylation of STAT protein
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042506 ! tyrosine phosphorylation of Stat5 protein
relationship: negatively_regulates GO:0042506 ! tyrosine phosphorylation of Stat5 protein

[Term]
id: GO:0042525
name: regulation of tyrosine phosphorylation of Stat6 protein
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat6 protein." [GOC:jl, PMID:11426647]
is_a: GO:0042509 ! regulation of tyrosine phosphorylation of STAT protein
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042505 ! tyrosine phosphorylation of Stat6 protein
relationship: regulates GO:0042505 ! tyrosine phosphorylation of Stat6 protein

[Term]
id: GO:0042526
name: positive regulation of tyrosine phosphorylation of Stat6 protein
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat6 protein." [GOC:jl, PMID:11426647]
synonym: "activation of tyrosine phosphorylation of Stat6 protein" NARROW []
synonym: "stimulation of tyrosine phosphorylation of Stat6 protein" NARROW []
synonym: "up regulation of tyrosine phosphorylation of Stat6 protein" EXACT []
synonym: "up-regulation of tyrosine phosphorylation of Stat6 protein" EXACT []
synonym: "upregulation of tyrosine phosphorylation of Stat6 protein" EXACT []
is_a: GO:0042525 ! regulation of tyrosine phosphorylation of Stat6 protein
is_a: GO:0042531 ! positive regulation of tyrosine phosphorylation of STAT protein
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042505 ! tyrosine phosphorylation of Stat6 protein
relationship: positively_regulates GO:0042505 ! tyrosine phosphorylation of Stat6 protein

[Term]
id: GO:0042527
name: negative regulation of tyrosine phosphorylation of Stat6 protein
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat6 protein." [GOC:jl, PMID:11426647]
synonym: "down regulation of tyrosine phosphorylation of Stat6 protein" EXACT []
synonym: "down-regulation of tyrosine phosphorylation of Stat6 protein" EXACT []
synonym: "downregulation of tyrosine phosphorylation of Stat6 protein" EXACT []
synonym: "inhibition of tyrosine phosphorylation of Stat6 protein" NARROW []
is_a: GO:0042525 ! regulation of tyrosine phosphorylation of Stat6 protein
is_a: GO:0042532 ! negative regulation of tyrosine phosphorylation of STAT protein
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042505 ! tyrosine phosphorylation of Stat6 protein
relationship: negatively_regulates GO:0042505 ! tyrosine phosphorylation of Stat6 protein

[Term]
id: GO:0042528
name: regulation of tyrosine phosphorylation of Stat7 protein
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat7 protein." [GOC:jl, PMID:11426647]
is_a: GO:0042509 ! regulation of tyrosine phosphorylation of STAT protein
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042507 ! tyrosine phosphorylation of Stat7 protein
relationship: regulates GO:0042507 ! tyrosine phosphorylation of Stat7 protein

[Term]
id: GO:0042529
name: positive regulation of tyrosine phosphorylation of Stat7 protein
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat7 protein." [GOC:jl, PMID:11426647]
synonym: "activation of tyrosine phosphorylation of Stat7 protein" NARROW []
synonym: "stimulation of tyrosine phosphorylation of Stat7 protein" NARROW []
synonym: "up regulation of tyrosine phosphorylation of Stat7 protein" EXACT []
synonym: "up-regulation of tyrosine phosphorylation of Stat7 protein" EXACT []
synonym: "upregulation of tyrosine phosphorylation of Stat7 protein" EXACT []
is_a: GO:0042528 ! regulation of tyrosine phosphorylation of Stat7 protein
is_a: GO:0042531 ! positive regulation of tyrosine phosphorylation of STAT protein
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042507 ! tyrosine phosphorylation of Stat7 protein
relationship: positively_regulates GO:0042507 ! tyrosine phosphorylation of Stat7 protein

[Term]
id: GO:0042530
name: negative regulation of tyrosine phosphorylation of Stat7 protein
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat7 protein." [GOC:jl, PMID:11426647]
synonym: "down regulation of tyrosine phosphorylation of Stat7 protein" EXACT []
synonym: "down-regulation of tyrosine phosphorylation of Stat7 protein" EXACT []
synonym: "downregulation of tyrosine phosphorylation of Stat7 protein" EXACT []
synonym: "inhibition of tyrosine phosphorylation of Stat7 protein" NARROW []
is_a: GO:0042528 ! regulation of tyrosine phosphorylation of Stat7 protein
is_a: GO:0042532 ! negative regulation of tyrosine phosphorylation of STAT protein
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042507 ! tyrosine phosphorylation of Stat7 protein
relationship: negatively_regulates GO:0042507 ! tyrosine phosphorylation of Stat7 protein

[Term]
id: GO:0042531
name: positive regulation of tyrosine phosphorylation of STAT protein
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:jl, PMID:11426647]
synonym: "activation of tyrosine phosphorylation of STAT protein" NARROW []
synonym: "stimulation of tyrosine phosphorylation of STAT protein" NARROW []
synonym: "up regulation of tyrosine phosphorylation of STAT protein" EXACT []
synonym: "up-regulation of tyrosine phosphorylation of STAT protein" EXACT []
synonym: "upregulation of tyrosine phosphorylation of STAT protein" EXACT []
is_a: GO:0042509 ! regulation of tyrosine phosphorylation of STAT protein
is_a: GO:0046427 ! positive regulation of JAK-STAT cascade
is_a: GO:0050731 ! positive regulation of peptidyl-tyrosine phosphorylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007260 ! tyrosine phosphorylation of STAT protein
relationship: positively_regulates GO:0007260 ! tyrosine phosphorylation of STAT protein

[Term]
id: GO:0042532
name: negative regulation of tyrosine phosphorylation of STAT protein
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:jl, PMID:11426647]
synonym: "down regulation of tyrosine phosphorylation of STAT protein" EXACT []
synonym: "down-regulation of tyrosine phosphorylation of STAT protein" EXACT []
synonym: "downregulation of tyrosine phosphorylation of STAT protein" EXACT []
synonym: "inhibition of tyrosine phosphorylation of STAT protein" NARROW []
is_a: GO:0042509 ! regulation of tyrosine phosphorylation of STAT protein
is_a: GO:0046426 ! negative regulation of JAK-STAT cascade
is_a: GO:0050732 ! negative regulation of peptidyl-tyrosine phosphorylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007260 ! tyrosine phosphorylation of STAT protein
relationship: negatively_regulates GO:0007260 ! tyrosine phosphorylation of STAT protein

[Term]
id: GO:0042533
name: tumor necrosis factor biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis." [GOC:jl, PMID:10891884]
comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF').
synonym: "TNF alpha biosynthesis" EXACT []
synonym: "TNF alpha biosynthetic process" EXACT []
synonym: "TNF biosynthesis" EXACT []
synonym: "TNF biosynthetic process" EXACT []
synonym: "TNF-alpha biosynthesis" EXACT []
synonym: "TNF-alpha biosynthetic process" EXACT []
synonym: "Tumor Necrosis Factor alpha biosynthesis" EXACT []
synonym: "Tumor Necrosis Factor alpha biosynthetic process" EXACT []
synonym: "tumor necrosis factor anabolism" EXACT []
synonym: "tumor necrosis factor biosynthesis" EXACT []
synonym: "tumor necrosis factor formation" EXACT []
synonym: "tumor necrosis factor synthesis" EXACT []
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032640 ! tumor necrosis factor production

[Term]
id: GO:0042534
name: regulation of tumor necrosis factor biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis." [GOC:jl, PMID:10891884]
comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF').
synonym: "regulation of TNF alpha biosynthesis" EXACT []
synonym: "regulation of TNF alpha biosynthetic process" EXACT []
synonym: "regulation of TNF biosynthesis" EXACT []
synonym: "regulation of TNF biosynthetic process" EXACT []
synonym: "regulation of TNF-alpha biosynthesis" EXACT []
synonym: "regulation of TNF-alpha biosynthetic process" EXACT []
synonym: "regulation of tumor necrosis factor anabolism" EXACT []
synonym: "regulation of tumor necrosis factor biosynthesis" EXACT []
synonym: "regulation of tumor necrosis factor formation" EXACT []
synonym: "regulation of tumor necrosis factor synthesis" EXACT []
synonym: "regulation of tumor necrosis factor-alpha biosynthesis" EXACT []
synonym: "regulation of tumor necrosis factor-alpha biosynthetic process" EXACT []
is_a: GO:0032680 ! regulation of tumor necrosis factor production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042533 ! tumor necrosis factor biosynthetic process
relationship: regulates GO:0042533 ! tumor necrosis factor biosynthetic process

[Term]
id: GO:0042535
name: positive regulation of tumor necrosis factor biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis." [GOC:jl, PMID:10891884]
comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF').
synonym: "activation of tumor necrosis factor biosynthetic process" NARROW []
synonym: "positive regulation of TNF alpha biosynthesis" EXACT []
synonym: "positive regulation of TNF alpha biosynthetic process" EXACT []
synonym: "positive regulation of TNF biosynthesis" EXACT []
synonym: "positive regulation of TNF biosynthetic process" EXACT []
synonym: "positive regulation of TNF-alpha biosynthesis" EXACT []
synonym: "positive regulation of TNF-alpha biosynthetic process" EXACT []
synonym: "positive regulation of tumor necrosis factor anabolism" EXACT []
synonym: "positive regulation of tumor necrosis factor biosynthesis" EXACT []
synonym: "positive regulation of tumor necrosis factor formation" EXACT []
synonym: "positive regulation of tumor necrosis factor synthesis" EXACT []
synonym: "positive regulation of tumor necrosis factor-alpha biosynthesis" EXACT []
synonym: "positive regulation of tumor necrosis factor-alpha biosynthetic process" EXACT []
synonym: "stimulation of tumor necrosis factor biosynthetic process" NARROW []
synonym: "up regulation of tumor necrosis factor biosynthetic process" EXACT []
synonym: "up-regulation of tumor necrosis factor biosynthetic process" EXACT []
synonym: "upregulation of tumor necrosis factor biosynthetic process" EXACT []
is_a: GO:0032760 ! positive regulation of tumor necrosis factor production
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0042534 ! regulation of tumor necrosis factor biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042533 ! tumor necrosis factor biosynthetic process
relationship: positively_regulates GO:0042533 ! tumor necrosis factor biosynthetic process

[Term]
id: GO:0042536
name: negative regulation of tumor necrosis factor biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis." [GOC:jl, PMID:10891884]
comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF').
synonym: "down regulation of tumor necrosis factor biosynthetic process" EXACT []
synonym: "down-regulation of tumor necrosis factor biosynthetic process" EXACT []
synonym: "downregulation of tumor necrosis factor biosynthetic process" EXACT []
synonym: "inhibition of tumor necrosis factor biosynthetic process" NARROW []
synonym: "negative regulation of TNF alpha biosynthesis" EXACT []
synonym: "negative regulation of TNF alpha biosynthetic process" EXACT []
synonym: "negative regulation of TNF biosynthesis" EXACT []
synonym: "negative regulation of TNF biosynthetic process" EXACT []
synonym: "negative regulation of TNF-alpha biosynthesis" EXACT []
synonym: "negative regulation of TNF-alpha biosynthetic process" EXACT []
synonym: "negative regulation of tumor necrosis factor anabolism" EXACT []
synonym: "negative regulation of tumor necrosis factor biosynthesis" EXACT []
synonym: "negative regulation of tumor necrosis factor formation" EXACT []
synonym: "negative regulation of tumor necrosis factor synthesis" EXACT []
synonym: "negative regulation of tumor necrosis factor-alpha biosynthesis" EXACT []
synonym: "negative regulation of tumor necrosis factor-alpha biosynthetic process" EXACT []
is_a: GO:0032720 ! negative regulation of tumor necrosis factor production
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0042534 ! regulation of tumor necrosis factor biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042533 ! tumor necrosis factor biosynthetic process
relationship: negatively_regulates GO:0042533 ! tumor necrosis factor biosynthetic process

[Term]
id: GO:0042537
name: benzene-containing compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving benzene, C6H6, a volatile, very inflammable liquid, contained in the naphtha produced by the destructive distillation of coal, from which it is separated by fractional distillation, or any of its derivatives." [CHEBI:22712, GOC:jl]
subset: gosubset_prok
synonym: "benzene and derivative metabolic process" EXACT [GOC:curators]
synonym: "benzene and derivative metabolism" EXACT []
synonym: "benzene-containing compound metabolism" EXACT [GOC:mah]
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process

[Term]
id: GO:0042538
name: hyperosmotic salinity response
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:jl]
synonym: "response to hyperosmotic salt stress" EXACT []
synonym: "salt tolerance" RELATED []
is_a: GO:0006972 ! hyperosmotic response
is_a: GO:0009651 ! response to salt stress

[Term]
id: GO:0042539
name: hypotonic salinity response
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:jl]
synonym: "response to hypotonic salt stress" EXACT []
is_a: GO:0006971 ! hypotonic response
is_a: GO:0009651 ! response to salt stress

[Term]
id: GO:0042540
name: hemoglobin catabolic process
namespace: biological_process
alt_id: GO:0020029
def: "The chemical reactions and pathways resulting in the breakdown of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin; especially, the proteolytic cleavage of hemoglobin to yield free heme, peptides, and amino acids." [CHEBI:35143, GOC:jl, GOC:mb]
comment: Note that 'hydrolysis' is actually a reaction rather than a process. The synonym 'hemoglobin hydrolysis' was the text string associated with the secondary ID GO:0020029, which was retained because its definition did describe a process.
synonym: "haemoglobin catabolic process" EXACT []
synonym: "haemoglobin catabolism" EXACT []
synonym: "haemoglobin hydrolysis" NARROW []
synonym: "hemoglobin breakdown" EXACT []
synonym: "hemoglobin catabolism" EXACT []
synonym: "hemoglobin degradation" EXACT []
synonym: "hemoglobin hydrolysis" NARROW []
is_a: GO:0020027 ! hemoglobin metabolic process
is_a: GO:0030163 ! protein catabolic process
is_a: GO:0044265 ! cellular macromolecule catabolic process

[Term]
id: GO:0042541
name: hemoglobin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin." [CHEBI:35143, GOC:jl]
synonym: "haemoglobin biosynthesis" EXACT []
synonym: "haemoglobin biosynthetic process" EXACT []
synonym: "hemoglobin anabolism" EXACT []
synonym: "hemoglobin biosynthesis" EXACT []
synonym: "hemoglobin formation" EXACT []
synonym: "hemoglobin synthesis" EXACT []
is_a: GO:0020027 ! hemoglobin metabolic process
is_a: GO:0034645 ! cellular macromolecule biosynthetic process

[Term]
id: GO:0042542
name: response to hydrogen peroxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus." [GOC:jl]
subset: gosubset_prok
is_a: GO:0000302 ! response to reactive oxygen species
is_a: GO:0010035 ! response to inorganic substance

[Term]
id: GO:0042543
name: protein N-linked glycosylation via arginine
namespace: biological_process
def: "The glycosylation of protein via peptidyl-arginine, omega-N-glycosyl-L-arginine." [RESID:AA0327]
subset: gosubset_prok
synonym: "protein amino acid N-linked glycosylation via arginine" EXACT [GOC:bf]
xref: RESID:AA0327
is_a: GO:0006487 ! protein N-linked glycosylation
is_a: GO:0018195 ! peptidyl-arginine modification

[Term]
id: GO:0042544
name: melibiose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of melibiose, the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "melibiose anabolism" EXACT []
synonym: "melibiose biosynthesis" EXACT []
synonym: "melibiose formation" EXACT []
synonym: "melibiose synthesis" EXACT []
is_a: GO:0005994 ! melibiose metabolic process
is_a: GO:0046351 ! disaccharide biosynthetic process

[Term]
id: GO:0042545
name: cell wall modification
namespace: biological_process
def: "The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly." [GOC:jl]
subset: gosubset_prok
is_a: GO:0071555 ! cell wall organization

[Term]
id: GO:0042546
name: cell wall biogenesis
namespace: biological_process
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cell wall. Includes biosynthesis of constituent macromolecules, such as proteins and polysaccharides, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component. A cell wall is the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:jl, GOC:mah, GOC:mtg_sensu, ISBN:0198506732]
subset: gosubset_prok
synonym: "cell wall assembly" NARROW []
is_a: GO:0044085 ! cellular component biogenesis
is_a: GO:0071554 ! cell wall organization or biogenesis

[Term]
id: GO:0042547
name: cell wall modification involved in multidimensional cell growth
namespace: biological_process
def: "The series of events resulting in chemical or structural changes to existing cell walls and contribute to multidimensional cell growth." [GOC:dph, GOC:jl, GOC:tb]
subset: gosubset_prok
synonym: "cell wall modification during cell expansion" EXACT []
synonym: "cell wall modification during multidimensional cell growth" RELATED [GOC:dph, GOC:tb]
is_a: GO:0042545 ! cell wall modification
intersection_of: GO:0042545 ! cell wall modification
intersection_of: part_of GO:0009825 ! multidimensional cell growth
relationship: part_of GO:0009825 ! multidimensional cell growth

[Term]
id: GO:0042548
name: regulation of photosynthesis, light reaction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the light-dependent reaction of photosynthesis." [GOC:jl]
is_a: GO:0010109 ! regulation of photosynthesis
is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019684 ! photosynthesis, light reaction
relationship: regulates GO:0019684 ! photosynthesis, light reaction

[Term]
id: GO:0042549
name: photosystem II stabilization
namespace: biological_process
def: "The stabilization of the photosystem II protein complex, resulting from the phosphorylation of its structural protein subunits, in a cell actively involved in photosynthesis." [GOC:go_curators]
is_a: GO:0042548 ! regulation of photosynthesis, light reaction

[Term]
id: GO:0042550
name: photosystem I stabilization
namespace: biological_process
def: "The stabilization of the photosystem I protein complex, resulting from the phosphorylation of its structural protein subunits, in a cell actively involved in photosynthesis." [GOC:go_curators]
is_a: GO:0042548 ! regulation of photosynthesis, light reaction

[Term]
id: GO:0042551
name: neuron maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a neuron to attain its fully functional state." [GOC:dph, GOC:jl]
is_a: GO:0048469 ! cell maturation
relationship: part_of GO:0048666 ! neuron development

[Term]
id: GO:0042552
name: myelination
namespace: biological_process
def: "The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier." [GOC:dgh, GOC:mah]
synonym: "myelinogenesis" RELATED [GOC:cjm, HP:0003429]
xref: Wikipedia:Myelin
is_a: GO:0008366 ! axon ensheathment

[Term]
id: GO:0042554
name: superoxide anion generation
namespace: biological_process
def: "The enzymatic generation of superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species, by a cell in response to environmental stress, thereby mediating the activation of various stress-inducible signaling pathways." [GOC:jl, PMID:12359750]
subset: gosubset_prok
synonym: "superoxide release" EXACT [GOC:hjd, GOC:mah]
is_a: GO:0006801 ! superoxide metabolic process

[Term]
id: GO:0042555
name: MCM complex
namespace: cellular_component
def: "A hexameric protein complex required for the initiation and regulation of DNA replication." [GOC:jl, PMID:11282021]
synonym: "mini-chromosome maintenance complex" EXACT []
is_a: GO:0043234 ! protein complex
relationship: has_part GO:0097373 ! MCM core complex

[Term]
id: GO:0042556
name: eukaryotic elongation factor-2 kinase regulator activity
namespace: molecular_function
def: "Modulates the activity of the enzyme eukaryotic elongation factor-2 kinase." [GOC:jl, PMID:11904175]
synonym: "eEF-2 kinase regulator" EXACT []
xref: EC:2.7.1.-
is_a: GO:0019887 ! protein kinase regulator activity
relationship: regulates GO:0004686 ! elongation factor-2 kinase activity

[Term]
id: GO:0042557
name: eukaryotic elongation factor-2 kinase activator activity
namespace: molecular_function
def: "Binds to and increases the activity of the enzyme eukaryotic elongation factor-2 kinase." [GOC:jl, PMID:11904175]
synonym: "eEF-2 kinase activator" EXACT []
xref: EC:2.7.1.-
is_a: GO:0030295 ! protein kinase activator activity
is_a: GO:0042556 ! eukaryotic elongation factor-2 kinase regulator activity
relationship: positively_regulates GO:0004686 ! elongation factor-2 kinase activity

[Term]
id: GO:0042558
name: pteridine-containing compound metabolic process
namespace: biological_process
alt_id: GO:0019721
def: "The chemical reactions and pathways involving any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "pteridine and derivative metabolic process" EXACT [GOC:curators]
synonym: "pteridine and derivative metabolism" EXACT [GOC:curators]
synonym: "pteridine-containing compound metabolism" EXACT [GOC:curators]
synonym: "pterin metabolic process" NARROW [CHEBI:26375, GOC:curators]
synonym: "pterin metabolism" NARROW [CHEBI:26375, GOC:curators]
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process

[Term]
id: GO:0042559
name: pteridine-containing compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "pteridine and derivative biosynthesis" EXACT [GOC:curators]
synonym: "pteridine and derivative biosynthetic process" EXACT [GOC:curators]
synonym: "pteridine-containing compound anabolism" EXACT [GOC:curators]
synonym: "pteridine-containing compound biosynthesis" EXACT [GOC:curators]
synonym: "pteridine-containing compound formation" EXACT [GOC:curators]
synonym: "pteridine-containing compound synthesis" EXACT [GOC:curators]
synonym: "pterin biosynthesis" NARROW [CHEBI:26375, GOC:curatos]
synonym: "pterin biosynthetic process" NARROW [CHEBI:26375, GOC:curators]
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0042558 ! pteridine-containing compound metabolic process
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process

[Term]
id: GO:0042560
name: pteridine-containing compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "pteridine and derivative catabolic process" EXACT [GOC:curators]
synonym: "pteridine and derivative catabolism" EXACT [GOC:curators]
synonym: "pteridine-containing compound breakdown" EXACT [GOC:curators]
synonym: "pteridine-containing compound catabolism" EXACT [GOC:curators]
synonym: "pteridine-containing compound degradation" EXACT [GOC:curators]
synonym: "pterin catabolic process" NARROW [CHEBI:26375, GOC:curators]
synonym: "pterin catabolism" NARROW [CHEBI:26375, GOC:curators]
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042558 ! pteridine-containing compound metabolic process
is_a: GO:0044270 ! cellular nitrogen compound catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process

[Term]
id: GO:0042561
name: alpha-amyrin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-2,3-epoxysqualene = alpha-amyrin. This reaction is a cyclization and rearrangement of (S)-2,3-epoxysqualene (2,3-oxidosqualene) into alpha-amyrin." [GOC:jl, MetaCyc:RXN-8434, PMID:10848960]
xref: MetaCyc:RXN-8434
is_a: GO:0031559 ! oxidosqualene cyclase activity

[Term]
id: GO:0042562
name: hormone binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone." [CHEBI:24621, GOC:jl]
subset: goslim_chembl
subset: goslim_pir
is_a: GO:0005488 ! binding

[Term]
id: GO:0042563
name: importin alpha-subunit nuclear export complex
namespace: cellular_component
def: "A protein complex which usually consists of three components, e.g. in Xenopus, the importin alpha-subunit/CAS/Ran, and which functions to shuttle the importin alpha-subunit out of the nucleus through the nuclear pore." [GOC:jl, PMID:9323123, PMID:9323134]
is_a: GO:0031074 ! nucleocytoplasmic shuttling complex

[Term]
id: GO:0042564
name: NLS-dependent protein nuclear import complex
namespace: cellular_component
def: "A protein complex which usually consists of three components, e.g. in Xenopus, the importin alpha and beta-subunits and any protein which has a nuclear localization sequence (NLS). The complex acts to import proteins with an NLS into the nucleus through a nuclear pore." [GOC:jl, PMID:9323123, PMID:9323134]
is_a: GO:0031074 ! nucleocytoplasmic shuttling complex

[Term]
id: GO:0042565
name: RNA nuclear export complex
namespace: cellular_component
def: "A complex which usually consists of three components, e.g. in Xenopus and yeast, the export receptor CRM1 (also known as exportin 1), the Ran protein and any RNA with a nuclear export sequence (NES). The complex acts to export RNA molecules with a NES from the nucleus through a nuclear pore." [GOC:jl, PMID:9323123]
is_a: GO:0031074 ! nucleocytoplasmic shuttling complex

[Term]
id: GO:0042566
name: hydrogenosome
namespace: cellular_component
def: "A spherical, membrane-bounded organelle found in some anaerobic protozoa, which participates in ATP and molecular hydrogen formation." [GOC:jl, PMID:11197234, PMID:11293569]
subset: goslim_pir
xref: Wikipedia:Hydrogenosome
is_a: GO:0043231 ! intracellular membrane-bounded organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0042567
name: insulin-like growth factor ternary complex
namespace: cellular_component
def: "A complex of three proteins, which in animals is approximately 150kDa and consists of the insulin-like growth factor (IGF), the insulin-like growth factor binding protein-3 (IGFBP-3), or -5 (IGFBP-5) and an acid-labile subunit (ALS). The complex plays a role in growth and development." [GOC:jl, PMID:12239079]
synonym: "IGF ternary complex" EXACT []
is_a: GO:0016942 ! insulin-like growth factor binding protein complex

[Term]
id: GO:0042568
name: insulin-like growth factor binary complex
namespace: cellular_component
def: "A complex of two proteins, which in animals is 50kDa and consists of the insulin-like growth factor (IGF) and one of the insulin-like growth factor binding protein-1 (IGFBP-1), -2 (IGFBP-2), -4 (IGFBP-4) and -6 (IGFBP-6). The complex plays a role in growth and development." [GOC:jl, PMID:12239079]
synonym: "IGF binary complex" EXACT []
is_a: GO:0016942 ! insulin-like growth factor binding protein complex

[Term]
id: GO:0042571
name: immunoglobulin complex, circulating
namespace: cellular_component
def: "An immunoglobulin complex that is secreted into extracellular space and found in mucosal areas or other tissues or circulating in the blood or lymph. In its canonical form, a circulating immunoglobulin complex is composed of two identical heavy chains and two identical light chains, held together by disulfide bonds. Some forms of are polymers of the basic structure and contain additional components such as J-chain and the secretory component." [GOC:add, ISBN:0781735149]
comment: Note that an immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
synonym: "antibody" EXACT [GOC:add]
xref: Wikipedia:Antibody
is_a: GO:0019814 ! immunoglobulin complex
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0042572
name: retinol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html, PMID:1924551]
subset: gosubset_prok
synonym: "retinol metabolism" EXACT []
synonym: "vitamin A1 alcohol metabolic process" EXACT []
synonym: "vitamin A1 alcohol metabolism" EXACT []
synonym: "vitamin A1 metabolic process" EXACT []
synonym: "vitamin A1 metabolism" EXACT []
xref: Wikipedia:Retinol
is_a: GO:0001523 ! retinoid metabolic process
is_a: GO:0034308 ! primary alcohol metabolic process
is_a: GO:0034754 ! cellular hormone metabolic process

[Term]
id: GO:0042573
name: retinoic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving retinoic acid, one of the three components that makes up vitamin A." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html]
subset: gosubset_prok
synonym: "retinoic acid metabolism" EXACT []
synonym: "vitamin A1 acid metabolic process" EXACT []
synonym: "vitamin A1 acid metabolism" EXACT []
is_a: GO:0001523 ! retinoid metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0034754 ! cellular hormone metabolic process

[Term]
id: GO:0042574
name: retinal metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving retinal, a compound that plays an important role in the visual process in most vertebrates. In the retina, retinal combines with opsins to form visual pigments. Retinal is one of the forms of vitamin A." [CHEBI:15035, GOC:curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "retinal metabolism" EXACT []
synonym: "retinaldehyde metabolic process" EXACT []
synonym: "retinaldehyde metabolism" EXACT []
is_a: GO:0001523 ! retinoid metabolic process
is_a: GO:0006081 ! cellular aldehyde metabolic process

[Term]
id: GO:0042575
name: DNA polymerase complex
namespace: cellular_component
def: "A protein complex that possesses DNA polymerase activity and is involved in template directed synthesis of DNA." [GOC:jl, PMID:12045093]
subset: goslim_metagenomics
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0044424 ! intracellular part
is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups

[Term]
id: GO:0042576
name: obsolete aspartyl aminopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate." [EC:3.4.11.21]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "aspartyl aminopeptidase activity" EXACT []
xref: EC:3.4.11.21
xref: MetaCyc:3.4.11.21-RXN
is_obsolete: true
replaced_by: GO:0004177

[Term]
id: GO:0042577
name: lipid phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: a phospholipid + H2O = a lipid + phosphate." [GOC:jl]
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0042578
name: phosphoric ester hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3." [GOC:jl]
subset: gosubset_prok
xref: EC:3.1.-.-
is_a: GO:0016788 ! hydrolase activity, acting on ester bonds

[Term]
id: GO:0042579
name: microbody
namespace: cellular_component
def: "Cytoplasmic organelles, spherical or oval in shape, that are bounded by a single membrane and contain oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2)." [ISBN:0198506732]
subset: goslim_pir
xref: Wikipedia:Microbody
is_a: GO:0043231 ! intracellular membrane-bounded organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0042580
name: mannosome
namespace: cellular_component
def: "A specialised tubular organelle, assembled in hexagonal bundles within an external membrane. Mannosomes are specific to molluscs and are thought to be involved in a general stress reaction." [GOC:jl, PMID:11912051, PMID:9799531]
is_a: GO:0005777 ! peroxisome

[Term]
id: GO:0042581
name: specific granule
namespace: cellular_component
def: "Granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase." [GOC:jl, ISBN:0721662544, PMID:7334549]
synonym: "secondary granule" EXACT []
xref: Wikipedia:Specific_granule
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0042582
name: azurophil granule
namespace: cellular_component
def: "Primary lysosomal granule found in neutrophil granulocytes. Contains a wide range of hydrolytic enzymes and is released into the extracellular fluid." [GOC:jl, PMID:17152095]
synonym: "primary granule" EXACT []
is_a: GO:0005766 ! primary lysosome
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0042583
name: chromaffin granule
namespace: cellular_component
def: "Specialized secretory vesicle found in the cells of adrenal glands and various other organs, which is concerned with the synthesis, storage, metabolism, and secretion of epinephrine and norepinephrine." [GOC:jl, PMID:19158310, PMID:1961743]
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0042584
name: chromaffin granule membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a chromaffin granule, a specialized secretory vesicle found in the cells of adrenal glands and various other organs, which is concerned with the synthesis, storage, metabolism, and secretion of epinephrine and norepinephrine." [GOC:jl]
is_a: GO:0030667 ! secretory granule membrane
relationship: part_of GO:0042583 ! chromaffin granule

[Term]
id: GO:0042585
name: germinal vesicle
namespace: cellular_component
def: "The enlarged, fluid filled nucleus of a primary oocyte, the development of which is suspended in prophase I of the first meiotic division between embryohood and sexual maturity." [GOC:jl, GOC:mtg_sensu, PMID:19019837]
synonym: "primary oocyte nucleus" EXACT []
is_a: GO:0001674 ! female germ cell nucleus

[Term]
id: GO:0042586
name: peptide deformylase activity
namespace: molecular_function
def: "Catalysis of the reaction: formyl-L-methionyl peptide + H2O = formate + methionyl peptide." [EC:3.5.1.88, GOC:jl]
subset: gosubset_prok
synonym: "formyl-L-methionyl peptide amidohydrolase activity" EXACT [EC:3.5.1.88]
synonym: "PDF activity" EXACT [EC:3.5.1.88]
synonym: "polypeptide deformylase activity" EXACT [EC:3.5.1.88]
xref: EC:3.5.1.88
xref: MetaCyc:3.5.1.88-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0042587
name: glycogen granule
namespace: cellular_component
def: "Cytoplasmic bead-like structures of animal cells, visible by electron microscope. Each granule is a functional unit with the biosynthesis and catabolism of glycogen being catalyzed by enzymes bound to the granule surface." [GOC:jl, http://148.216.10.83/cellbio/the_mi19.gif, PMID:12179957]
synonym: "glycogen particle" EXACT []
xref: NIF_Subcellular:sao1081228141
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0042588
name: zymogen granule
namespace: cellular_component
def: "A membrane-bounded, cytoplasmic secretory granule found in enzyme-secreting cells and visible by light microscopy. Contain zymogen, an inactive enzyme precursor, often of a digestive enzyme." [GOC:jl, ISBN:0198506732]
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0042589
name: zymogen granule membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a zymogen granule." [GOC:jl]
is_a: GO:0030667 ! secretory granule membrane
relationship: part_of GO:0042588 ! zymogen granule

[Term]
id: GO:0042590
name: antigen processing and presentation of exogenous peptide antigen via MHC class I
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:15771591]
synonym: "antigen presentation, exogenous antigen via major histocompatibility complex class I" EXACT []
synonym: "antigen presentation, exogenous antigen via MHC class I" EXACT []
synonym: "cross presentation" BROAD []
synonym: "cross priming" BROAD []
synonym: "cross-presentation" BROAD []
synonym: "cross-priming" BROAD []
synonym: "exogenous peptide antigen processing and presentation via MHC class I" EXACT []
xref: Reactome:REACT_111119 "Antigen processing-Cross presentation, Homo sapiens"
is_a: GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I
is_a: GO:0002478 ! antigen processing and presentation of exogenous peptide antigen

[Term]
id: GO:0042592
name: homeostatic process
namespace: biological_process
def: "Any biological process involved in the maintenance of an internal steady state." [GOC:jl, ISBN:0395825172]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: gosubset_prok
synonym: "homeostasis" RELATED []
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0042593
name: glucose homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of glucose within an organism or cell." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0033500 ! carbohydrate homeostasis

[Term]
id: GO:0042594
name: response to starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators]
subset: goslim_yeast
subset: gosubset_prok
is_a: GO:0006950 ! response to stress
is_a: GO:0031667 ! response to nutrient levels

[Term]
id: GO:0042595
name: behavioral response to starvation
namespace: biological_process
def: "Any process that results in a change in the behavior of an organism as a result of deprivation of nourishment." [GOC:go_curators]
synonym: "behavioural response to starvation" EXACT []
is_a: GO:0042594 ! response to starvation

[Term]
id: GO:0042596
name: fear response
namespace: biological_process
alt_id: GO:0001663
def: "The response of an organism to a perceived external threat." [GOC:go_curators]
synonym: "physiological fear response" EXACT []
is_a: GO:0033555 ! multicellular organismal response to stress

[Term]
id: GO:0042597
name: periplasmic space
namespace: cellular_component
alt_id: GO:0005620
def: "The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria)." [GOC:go_curators, GOC:md]
subset: goslim_metagenomics
subset: goslim_pir
subset: gosubset_prok
synonym: "periplasm" EXACT []
is_a: GO:0044464 ! cell part

[Term]
id: GO:0042598
name: obsolete vesicular fraction
namespace: cellular_component
def: "OBSOLETE: Any of the small, heterogeneous, artifactual, vesicular particles that are formed when some cells are homogenized." [GOC:jl]
comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component.
subset: gosubset_prok
synonym: "vesicular fraction" EXACT []
is_obsolete: true
consider: GO:0031982

[Term]
id: GO:0042599
name: lamellar body
namespace: cellular_component
def: "A membrane-bounded organelle, specialized for the storage and secretion of various substances (surfactant phospholipids, glycoproteins and acid phosphates) which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae. Has some similar properties to, but is distinct from, a lysosome." [GOC:cjm, GOC:jl, http://en.wikipedia.org/wiki/Lamellar_granule, PMID:12243725]
synonym: "keratinosome" NARROW []
synonym: "lamellar granule" EXACT []
synonym: "membrane-coating granule" EXACT []
synonym: "Odland body" NARROW []
xref: NIF_Subcellular:sao1379604862
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0042600
name: chorion
namespace: cellular_component
def: "A protective, noncellular membrane that surrounds the eggs of various animals including insects and fish." [GOC:jl, ISBN:0721662544]
comment: Note that this term does not refer to the extraembryonic membrane surrounding the embryo of amniote vertebrates as this is an anatomical structure and is therefore not covered by GO.
subset: goslim_pir
is_a: GO:0030312 ! external encapsulating structure

[Term]
id: GO:0042601
name: endospore-forming forespore
namespace: cellular_component
def: "Portion of the cell formed during the process of bacterial sporulation that will ultimately become the core of the endospore. An endospore is a type of dormant cell that is resistant to adverse conditions." [GOC:jl, GOC:mtg_sensu, ISBN:0697286029]
subset: gosubset_prok
is_a: GO:0042763 ! intracellular immature spore

[Term]
id: GO:0042602
name: riboflavin reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: reduced riboflavin + NADP+ = riboflavin + NADPH + 2 H+." [EC:1.5.1.30]
subset: gosubset_prok
synonym: "flavin reductase activity" RELATED [EC:1.5.1.30]
synonym: "FMN reductase (NADPH) activity" RELATED [EC:1.5.1.30]
synonym: "NADPH dehydrogenase (riboflavin) activity" EXACT [EC:1.5.1.30]
synonym: "NADPH-dependent FMN reductase activity" RELATED [EC:1.5.1.30]
synonym: "NADPH-FMN reductase activity" RELATED [EC:1.5.1.30]
synonym: "NADPH-riboflavin oxidoreductase activity" EXACT []
synonym: "NADPH-riboflavin reductase activity" EXACT [EC:1.5.1.30]
synonym: "NADPH-specific FMN reductase activity" RELATED [EC:1.5.1.30]
synonym: "NADPH2 dehydrogenase (riboflavin)" EXACT [EC:1.5.1.30]
synonym: "NADPH2:riboflavin oxidoreductase activity" EXACT [EC:1.5.1.30]
synonym: "NADPH:riboflavin oxidoreductase activity" EXACT [EC:1.5.1.30]
synonym: "reduced-riboflavin:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.30]
synonym: "riboflavin mononucleotide (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.5.1.30]
synonym: "riboflavin mononucleotide reductase activity" BROAD [EC:1.5.1.30]
synonym: "riboflavine mononucleotide reductase activity" BROAD [EC:1.5.1.30]
xref: EC:1.5.1.30
xref: EC:1.5.1.41
xref: KEGG:R05707
xref: MetaCyc:NADPH-DEHYDROGENASE-FLAVIN-RXN
xref: RHEA:19380
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0042603
name: capsule
namespace: cellular_component
alt_id: GO:0030113
alt_id: GO:0042604
def: "A protective structure surrounding some fungi and bacteria, attached externally to the cell wall and composed primarily of polysaccharides. Capsules are highly organized structures that adhere strongly to cells and cannot be easily removed. Capsules play important roles in pathogenicity, preventing phagocytosis by other cells, adherance, and resistance to dessication." [GOC:mlg]
subset: gosubset_prok
xref: Wikipedia:Capsule_(microbiology)
is_a: GO:0030112 ! glycocalyx

[Term]
id: GO:0042605
name: peptide antigen binding
namespace: molecular_function
alt_id: GO:0042606
alt_id: GO:0042607
def: "Interacting selectively and non-covalently with an antigen peptide." [GOC:add, GOC:jl, GOC:rv]
comment: Note that this term can be used to describe the binding of a peptide to an MHC molecule.
subset: goslim_chembl
synonym: "endogenous peptide antigen binding" NARROW []
synonym: "exogenous peptide antigen binding" NARROW []
is_a: GO:0003823 ! antigen binding
is_a: GO:0042277 ! peptide binding

[Term]
id: GO:0042608
name: T cell receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a T cell receptor, the antigen-recognizing receptor on the surface of T cells." [GOC:jl]
synonym: "T lymphocyte receptor binding" EXACT []
synonym: "T-cell receptor binding" EXACT []
synonym: "T-lymphocyte receptor binding" EXACT []
synonym: "TCR binding" EXACT []
is_a: GO:0005102 ! receptor binding
is_a: GO:0032403 ! protein complex binding

[Term]
id: GO:0042609
name: CD4 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a CD4, a receptor found on the surface of T cells, monocytes and macrophages." [GOC:jl, MSH:D015704]
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0042610
name: CD8 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a CD8, a receptor found on the surface of thymocytes and cytotoxic and suppressor T-lymphocytes." [GOC:jl, MSH:D016827]
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0042611
name: MHC protein complex
namespace: cellular_component
def: "A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen." [GOC:add, GOC:jl, ISBN:0781735149, PMID:15928678, PMID:16153240]
subset: goslim_pir
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0042612
name: MHC class I protein complex
namespace: cellular_component
def: "A transmembrane protein complex composed of a MHC class I alpha chain and an invariant beta2-microglobin chain, and with or without a bound peptide antigen. Class I here refers to classical class I molecules." [GOC:add, GOC:jl, ISBN:0120781859, ISBN:0781735149]
comment: See also the cellular component term 'MHC class I peptide loading complex ; GO:0042824'.
is_a: GO:0042611 ! MHC protein complex

[Term]
id: GO:0042613
name: MHC class II protein complex
namespace: cellular_component
def: "A transmembrane protein complex composed of an MHC class II alpha and MHC class II beta chain, and with or without a bound peptide or polysaccharide antigen." [GOC:add, GOC:jl, ISBN:0120781859, PMID:15928678]
is_a: GO:0042611 ! MHC protein complex

[Term]
id: GO:0042614
name: CD70 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a CD70, a receptor found on the surface of most activated B cells and some activated T cells." [GOC:jl, ISBN:0120781859]
synonym: "CD27 receptor activity" RELATED []
synonym: "CD27L binding" EXACT []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0042615
name: CD154 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with CD154, a receptor found on the surface of some activated lymphocytes." [GOC:jl, ISBN:0120781859]
synonym: "CD40 receptor activity" RELATED []
synonym: "CD40L binding" EXACT []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0042616
name: paclitaxel metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving paclitaxel, an alkaloid compound used as an anticancer treatment." [CHEBI:45863, GOC:jl]
subset: gosubset_prok
synonym: "paclitaxel metabolism" EXACT []
synonym: "taxol metabolic process" NARROW []
synonym: "taxol metabolism" NARROW []
is_a: GO:0016101 ! diterpenoid metabolic process
is_a: GO:0034641 ! cellular nitrogen compound metabolic process

[Term]
id: GO:0042617
name: paclitaxel biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of paclitaxel, an alkaloid compound used as an anticancer treatment." [CHEBI:45863, GOC:jl]
subset: gosubset_prok
synonym: "paclitaxel anabolism" EXACT []
synonym: "paclitaxel biosynthesis" EXACT []
synonym: "paclitaxel formation" EXACT []
synonym: "paclitaxel synthesis" EXACT []
synonym: "taxol biosynthesis" NARROW []
synonym: "taxol biosynthetic process" NARROW []
is_a: GO:0016102 ! diterpenoid biosynthetic process
is_a: GO:0042616 ! paclitaxel metabolic process

[Term]
id: GO:0042618
name: poly-hydroxybutyrate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving poly-hydroxybutyrate (PHB), a polymer of beta-hydroxybutyrate and a common storage material of prokaryotic cells." [GOC:jl, http://biotech.icmb.utexas.edu/search/dict-search.html]
subset: gosubset_prok
synonym: "PHB metabolic process" EXACT []
synonym: "PHB metabolism" EXACT []
synonym: "poly-hydroxybutyrate metabolism" EXACT []
is_a: GO:1901440 ! poly(hydroxyalkanoate) metabolic process

[Term]
id: GO:0042619
name: poly-hydroxybutyrate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of poly-hydroxybutyrate (PHB), a polymer of beta-hydroxybutyrate and a common storage material of prokaryotic cells." [GOC:jl, http://biotech.icmb.utexas.edu/search/dict-search.html]
subset: gosubset_prok
synonym: "PHB biosynthesis" EXACT []
synonym: "PHB biosynthetic process" EXACT []
synonym: "poly-hydroxybutyrate anabolism" EXACT []
synonym: "poly-hydroxybutyrate biosynthesis" EXACT []
synonym: "poly-hydroxybutyrate formation" EXACT []
synonym: "poly-hydroxybutyrate synthesis" EXACT []
is_a: GO:0042618 ! poly-hydroxybutyrate metabolic process
is_a: GO:1901441 ! poly(hydroxyalkanoate) biosynthetic process

[Term]
id: GO:0042620
name: poly(3-hydroxyalkanoate) metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving poly(3-hydroxyalkanoates), polyesters of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria." [GOC:jl, PMID:9925580]
subset: goslim_pir
subset: gosubset_prok
synonym: "PHA metabolic process" BROAD []
synonym: "PHA metabolism" BROAD []
synonym: "poly(3-hydroxyalkanoate) metabolism" EXACT []
is_a: GO:0071704 ! organic substance metabolic process

[Term]
id: GO:0042621
name: poly(3-hydroxyalkanoate) biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of poly(3-hydroxyalkanoates), polyesters of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria." [GOC:jl, PMID:9925580]
subset: gosubset_prok
synonym: "PHA biosynthesis" BROAD []
synonym: "PHA biosynthetic process" BROAD []
synonym: "poly(3-hydroxyalkanoate) anabolism" EXACT []
synonym: "poly(3-hydroxyalkanoate) biosynthesis" EXACT []
synonym: "poly(3-hydroxyalkanoate) formation" EXACT []
synonym: "poly(3-hydroxyalkanoate) synthesis" EXACT []
is_a: GO:0042620 ! poly(3-hydroxyalkanoate) metabolic process
is_a: GO:1901576 ! organic substance biosynthetic process

[Term]
id: GO:0042622
name: photoreceptor outer segment membrane
namespace: cellular_component
def: "The membrane surrounding the outer segment of a vertebrate photoreceptor." [GOC:jl]
is_a: GO:0060170 ! ciliary membrane
is_a: GO:0097458 ! neuron part
relationship: part_of GO:0001750 ! photoreceptor outer segment

[Term]
id: GO:0042623
name: ATPase activity, coupled
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl]
subset: gosubset_prok
synonym: "ATP phosphohydrolase (polypeptide-unfolding)" NARROW [EC:3.6.4.9]
synonym: "chaperonin" RELATED [EC:3.6.4.9]
synonym: "chaperonin ATPase activity" RELATED []
synonym: "non-chaperonin molecular chaperone ATPase activity" RELATED []
synonym: "nucleoplasmin ATPase activity" RELATED []
synonym: "peroxisome-assembly ATPase activity" RELATED []
synonym: "vesicle-fusing ATPase activity" RELATED [EC:3.6.4.6]
is_a: GO:0016887 ! ATPase activity

[Term]
id: GO:0042624
name: ATPase activity, uncoupled
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction is not directly coupled to any other reaction." [EC:3.6.1.3]
subset: gosubset_prok
synonym: "adenylpyrophosphatase activity" RELATED [EC:3.6.1.3]
is_a: GO:0016887 ! ATPase activity

[Term]
id: GO:0042625
name: ATPase coupled ion transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of an ion from one side of a membrane to the other, driven by the reaction: ATP + H2O = ADP + phosphate." [EC:3.6.1.3, GOC:jl, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "ATPase activity, coupled to transmembrane movement of ions" EXACT []
is_a: GO:0022853 ! active ion transmembrane transporter activity
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances

[Term]
id: GO:0042626
name: ATPase activity, coupled to transmembrane movement of substances
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl]
subset: gosubset_prok
synonym: "ABC transporter" NARROW []
synonym: "ABC-type efflux permease activity" NARROW []
synonym: "ABC-type efflux porter activity" NARROW []
synonym: "ABC-type uptake permease activity" NARROW []
synonym: "ATP binding cassette transporter" NARROW []
synonym: "ATP-binding cassette (ABC) transporter activity" NARROW []
synonym: "ATP-binding cassette transporter" NARROW []
synonym: "mating pheromone exporter" NARROW []
xref: Reactome:REACT_111189 "ABCA4 mediates retinal transport, Homo sapiens"
xref: Reactome:REACT_118120 "ABCC1 mediates LTC4 export from the cell, Schizosaccharomyces pombe"
xref: Reactome:REACT_118121 "ABCC1 mediates LTC4 export from the cell, Rattus norvegicus"
xref: Reactome:REACT_118141 "ABCC1 mediates LTC4 export from the cell, Canis familiaris"
xref: Reactome:REACT_118269 "ABCC1 mediates LTC4 export from the cell, Sus scrofa"
xref: Reactome:REACT_118294 "ABCC1 mediates LTC4 export from the cell, Danio rerio"
xref: Reactome:REACT_118298 "ABCC1 mediates LTC4 export from the cell, Taeniopygia guttata"
xref: Reactome:REACT_118340 "ABCC1 mediates LTC4 export from the cell, Saccharomyces cerevisiae"
xref: Reactome:REACT_118343 "ABCC1 mediates LTC4 export from the cell, Gallus gallus"
xref: Reactome:REACT_118360 "ABCC1 mediates LTC4 export from the cell, Xenopus tropicalis"
xref: Reactome:REACT_118361 "ABCC1 mediates LTC4 export from the cell, Bos taurus"
xref: Reactome:REACT_118365 "ABCC1 mediates LTC4 export from the cell, Dictyostelium discoideum"
xref: Reactome:REACT_118397 "ABCC1 mediates LTC4 export from the cell, Caenorhabditis elegans"
xref: Reactome:REACT_118433 "ABCC1 mediates LTC4 export from the cell, Mus musculus"
xref: Reactome:REACT_15474 "ABCC1 mediates LTC4 export from the cell, Homo sapiens"
is_a: GO:0015405 ! P-P-bond-hydrolysis-driven transmembrane transporter activity
is_a: GO:0016820 ! hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
is_a: GO:0043492 ! ATPase activity, coupled to movement of substances

[Term]
id: GO:0042627
name: chylomicron
namespace: cellular_component
def: "A large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE. Chylomicrons are found in blood or lymph and carry lipids from the intestines into other body tissues." [GOC:jl, GOC:rl, http://biotech.icmb.utexas.edu/search/dict-search.html, PMID:10580165]
xref: Wikipedia:Chylomicron
is_a: GO:0034358 ! plasma lipoprotein particle

[Term]
id: GO:0042628
name: mating plug formation
namespace: biological_process
def: "The deposition of a plug of sperm or other gelatinous material into the opening of the vulva by a male at the termination of copulation. Probably acts to prevent subsequent matings by other males." [GOC:jl, http://www.wildcru.org/glossary/glossary.htm, http://www.wormatlas.org/glossaries/cglossary.htm, PMID:11267893]
synonym: "copulatory plug biosynthesis" EXACT []
synonym: "copulatory plug deposition" EXACT []
synonym: "copulatory plug formation" EXACT []
synonym: "mating plug deposition" EXACT []
is_a: GO:0007617 ! mating behavior
is_a: GO:0044704 ! single-organism reproductive behavior
is_a: GO:0045297 ! post-mating behavior
relationship: part_of GO:0007320 ! insemination

[Term]
id: GO:0042629
name: mast cell granule
namespace: cellular_component
def: "Coarse, bluish-black staining cytoplasmic granules, bounded by a plasma membrane and found in mast cells and basophils. Contents include histamine, heparin, chondroitin sulfates, chymase and tryptase." [GOC:jl, http://www.ijp-online.com/archives/1969/001/02/r0000-0000tc.htm, PMID:12360215]
is_a: GO:0005764 ! lysosome

[Term]
id: GO:0042630
name: behavioral response to water deprivation
namespace: biological_process
def: "Any process that results in a change in the behavior of an organism as a result of deprivation of water." [GOC:jl]
synonym: "behavioral response to drought" EXACT []
synonym: "behavioral response to thirst" EXACT []
synonym: "behavioural response to water deprivation" EXACT []
is_a: GO:0044708 ! single-organism behavior
relationship: part_of GO:0009414 ! response to water deprivation

[Term]
id: GO:0042631
name: cellular response to water deprivation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of water." [GOC:go_curators]
synonym: "cellular response to drought" EXACT []
is_a: GO:0009414 ! response to water deprivation
is_a: GO:0031668 ! cellular response to extracellular stimulus
is_a: GO:0033554 ! cellular response to stress
is_a: GO:0071462 ! cellular response to water stimulus

[Term]
id: GO:0042632
name: cholesterol homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell." [GOC:go_curators]
is_a: GO:0055092 ! sterol homeostasis

[Term]
id: GO:0042633
name: hair cycle
namespace: biological_process
def: "The cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body." [GOC:go_curators, PMID:12230507]
is_a: GO:0042303 ! molting cycle

[Term]
id: GO:0042634
name: regulation of hair cycle
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair." [GOC:go_curators, PMID:12230507]
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042633 ! hair cycle
relationship: regulates GO:0042633 ! hair cycle

[Term]
id: GO:0042635
name: positive regulation of hair cycle
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair." [GOC:go_curators, PMID:12230507]
synonym: "activation of hair cycle" NARROW []
synonym: "stimulation of hair cycle" NARROW []
synonym: "up regulation of hair cycle" EXACT []
synonym: "up-regulation of hair cycle" EXACT []
synonym: "upregulation of hair cycle" EXACT []
is_a: GO:0042634 ! regulation of hair cycle
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042633 ! hair cycle
relationship: positively_regulates GO:0042633 ! hair cycle

[Term]
id: GO:0042636
name: negative regulation of hair cycle
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair." [GOC:go_curators, PMID:12230507]
synonym: "down regulation of hair cycle" EXACT []
synonym: "down-regulation of hair cycle" EXACT []
synonym: "downregulation of hair cycle" EXACT []
synonym: "inhibition of hair cycle" NARROW []
is_a: GO:0042634 ! regulation of hair cycle
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042633 ! hair cycle
relationship: negatively_regulates GO:0042633 ! hair cycle

[Term]
id: GO:0042637
name: catagen
namespace: biological_process
def: "The regression phase of the hair cycle during which cell proliferation ceases, the hair follicle shortens, and an anchored club hair is produced." [PMID:12535193]
subset: gocheck_do_not_annotate
synonym: "hair regression" NARROW []
is_a: GO:0044851 ! hair cycle phase
relationship: part_of GO:0048820 ! hair follicle maturation

[Term]
id: GO:0042638
name: exogen
namespace: biological_process
def: "The shedding phase of the hair cycle." [PMID:12230507]
subset: gocheck_do_not_annotate
synonym: "hair shedding" NARROW []
is_a: GO:0044851 ! hair cycle phase
relationship: part_of GO:0048820 ! hair follicle maturation

[Term]
id: GO:0042639
name: telogen
namespace: biological_process
def: "The resting phase of hair cycle." [PMID:12230507]
subset: gocheck_do_not_annotate
synonym: "hair resting phase" NARROW []
is_a: GO:0044851 ! hair cycle phase

[Term]
id: GO:0042640
name: anagen
namespace: biological_process
def: "The growth phase of the hair cycle. Lasts, for example, about 3 to 6 years for human scalp hair." [PMID:12230507]
subset: gocheck_do_not_annotate
synonym: "hair growth" RELATED []
is_a: GO:0044851 ! hair cycle phase
relationship: part_of GO:0048820 ! hair follicle maturation

[Term]
id: GO:0042641
name: actomyosin
namespace: cellular_component
def: "Any complex of actin, myosin, and accessory proteins." [GOC:go_curators]
synonym: "actomyosin complex" EXACT []
synonym: "actomyosin structure" EXACT []
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0015629 ! actin cytoskeleton

[Term]
id: GO:0042642
name: actomyosin, myosin complex part
namespace: cellular_component
def: "The myosin part of any complex of actin, myosin, and accessory proteins." [GOC:go_curators]
is_a: GO:0016459 ! myosin complex
intersection_of: GO:0016459 ! myosin complex
intersection_of: part_of GO:0042641 ! actomyosin
relationship: part_of GO:0042641 ! actomyosin

[Term]
id: GO:0042643
name: actomyosin, actin portion
namespace: cellular_component
def: "The actin part of any complex of actin, myosin, and accessory proteins." [GOC:go_curators]
is_a: GO:0005884 ! actin filament
intersection_of: GO:0005884 ! actin filament
intersection_of: part_of GO:0042641 ! actomyosin
relationship: part_of GO:0042641 ! actomyosin

[Term]
id: GO:0042644
name: chloroplast nucleoid
namespace: cellular_component
def: "The region of a chloroplast to which the DNA is confined." [GOC:jl]
is_a: GO:0042646 ! plastid nucleoid
is_a: GO:0044434 ! chloroplast part
intersection_of: GO:0009295 ! nucleoid
intersection_of: part_of GO:0009507 ! chloroplast
relationship: part_of GO:0009507 ! chloroplast
relationship: part_of GO:0009570 ! chloroplast stroma

[Term]
id: GO:0042645
name: mitochondrial nucleoid
namespace: cellular_component
def: "The region of a mitochondrion to which the DNA is confined." [GOC:jl]
is_a: GO:0009295 ! nucleoid
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle
is_a: GO:0044429 ! mitochondrial part
intersection_of: GO:0009295 ! nucleoid
intersection_of: part_of GO:0005739 ! mitochondrion
relationship: part_of GO:0005739 ! mitochondrion
relationship: part_of GO:0005759 ! mitochondrial matrix

[Term]
id: GO:0042646
name: plastid nucleoid
namespace: cellular_component
def: "The region of a plastid to which the DNA is confined." [GOC:jl]
is_a: GO:0009295 ! nucleoid
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle
is_a: GO:0044435 ! plastid part
intersection_of: GO:0009295 ! nucleoid
intersection_of: part_of GO:0009536 ! plastid
relationship: part_of GO:0009532 ! plastid stroma
relationship: part_of GO:0009536 ! plastid

[Term]
id: GO:0042647
name: proplastid nucleoid
namespace: cellular_component
def: "The region of a proplastid to which the DNA is confined." [GOC:jl]
is_a: GO:0042646 ! plastid nucleoid
intersection_of: GO:0009295 ! nucleoid
intersection_of: part_of GO:0009537 ! proplastid
relationship: part_of GO:0009537 ! proplastid
relationship: part_of GO:0009571 ! proplastid stroma

[Term]
id: GO:0042648
name: chloroplast chromosome
namespace: cellular_component
def: "A circular DNA molecule containing chloroplast encoded genes." [GOC:jl]
is_a: GO:0009508 ! plastid chromosome
is_a: GO:0044434 ! chloroplast part
intersection_of: GO:0005694 ! chromosome
intersection_of: part_of GO:0009507 ! chloroplast
relationship: part_of GO:0009507 ! chloroplast
relationship: part_of GO:0042644 ! chloroplast nucleoid

[Term]
id: GO:0042649
name: prothylakoid
namespace: cellular_component
def: "Underdeveloped thylakoids found in etioplasts, lacking competent photosynthetic membranes. Rapidly develop into mature thylakoids in the presence of light." [GOC:jl, PMID:11532175]
is_a: GO:0031976 ! plastid thylakoid
relationship: part_of GO:0009513 ! etioplast

[Term]
id: GO:0042650
name: prothylakoid membrane
namespace: cellular_component
def: "The membrane of prothylakoids, underdeveloped thylakoids found in etioplasts, lacking competent photosynthetic membranes." [GOC:jl, PMID:11532175]
is_a: GO:0055035 ! plastid thylakoid membrane
relationship: part_of GO:0042649 ! prothylakoid

[Term]
id: GO:0042651
name: thylakoid membrane
namespace: cellular_component
def: "The pigmented membrane of any thylakoid." [GOC:jl, GOC:pr]
subset: gosubset_prok
is_a: GO:0034357 ! photosynthetic membrane

[Term]
id: GO:0042652
name: mitochondrial respiratory chain complex I, peripheral segment
namespace: cellular_component
def: "The peripheral segment of respiratory chain complex I located in the mitochondrion. Respiratory chain complex I is an enzyme of the respiratory chain, consisting of at least 34 polypeptide chains. The electrons of NADH enter the chain at this complex. The complete complex is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix." [GOC:jid, GOC:mtg_sensu, ISBN:0716749556]
synonym: "NADH dehydrogenase (ubiquinone) complex, peripheral segment" BROAD []
synonym: "NADH-Q oxidoreductase complex, peripheral segment" BROAD []
is_a: GO:0098800 ! inner mitochondrial membrane protein complex
is_a: GO:0098803 ! respiratory chain complex
relationship: part_of GO:0005747 ! mitochondrial respiratory chain complex I

[Term]
id: GO:0042653
name: mitochondrial respiratory chain complex I, membrane segment
namespace: cellular_component
def: "The mitochondrial membrane segment of respiratory chain complex I. Respiratory chain complex I is an enzyme of the respiratory chain, consisting of at least 34 polypeptide chains. The electrons of NADH enter the chain at this complex. The complete complex is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix." [GOC:jid, GOC:mtg_sensu, ISBN:0716749556]
synonym: "NADH-Q oxidoreductase complex, membrane segment" BROAD []
is_a: GO:0098800 ! inner mitochondrial membrane protein complex
is_a: GO:0098803 ! respiratory chain complex
relationship: part_of GO:0005747 ! mitochondrial respiratory chain complex I

[Term]
id: GO:0042654
name: ecdysis-triggering hormone receptor activity
namespace: molecular_function
def: "Combining with ecdysis-triggering hormone to initiate a change in cell activity." [GOC:ma]
synonym: "ecdysis-triggering hormone binding" NARROW []
synonym: "ETH receptor" EXACT []
is_a: GO:0004930 ! G-protein coupled receptor activity
relationship: has_part GO:0042562 ! hormone binding

[Term]
id: GO:0042655
name: activation of JNKKK activity
namespace: biological_process
def: "The initiation of the activity of the inactive enzyme JUN kinase kinase kinase (JNKKK) activity." [GOC:bf]
synonym: "activation of JUN kinase kinase kinase activity" EXACT []
synonym: "positive regulation of JUNKKK activity" BROAD []
is_a: GO:0000185 ! activation of MAPKKK activity
is_a: GO:0043506 ! regulation of JUN kinase activity
is_a: GO:0046330 ! positive regulation of JNK cascade
relationship: part_of GO:0007254 ! JNK cascade
relationship: positively_regulates GO:0004706 ! JUN kinase kinase kinase activity

[Term]
id: GO:0042656
name: JUN kinase kinase kinase kinase activity
namespace: molecular_function
def: "Catalysis of the phosphorylation and activation of JUN kinase kinase kinases (JNKKKs)." [GOC:bf]
synonym: "JUNKKKK activity" EXACT []
is_a: GO:0008349 ! MAP kinase kinase kinase kinase activity
relationship: part_of GO:0042655 ! activation of JNKKK activity

[Term]
id: GO:0042657
name: MHC class II protein binding, via lateral surface
namespace: molecular_function
def: "Interacting selectively and non-covalently with the lateral surface of major histocompatibility complex class II molecules." [GOC:jl]
synonym: "major histocompatibility complex class II protein binding, via lateral surface" EXACT []
is_a: GO:0042289 ! MHC class II protein binding

[Term]
id: GO:0042658
name: MHC class II protein binding, via antigen binding groove
namespace: molecular_function
def: "Interacting selectively and non-covalently with the antigen binding groove of major histocompatibility complex class II molecules." [GOC:jl]
synonym: "major histocompatibility complex class II protein binding, via antigen binding groove" EXACT []
is_a: GO:0042289 ! MHC class II protein binding
relationship: part_of GO:0023026 ! MHC class II protein complex binding

[Term]
id: GO:0042659
name: regulation of cell fate specification
namespace: biological_process
def: "Any process that mediates the adoption of a specific fate by a cell." [GOC:go_curators]
is_a: GO:0010453 ! regulation of cell fate commitment
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001708 ! cell fate specification
relationship: regulates GO:0001708 ! cell fate specification

[Term]
id: GO:0042660
name: positive regulation of cell fate specification
namespace: biological_process
def: "Any process that activates or enables a cell to adopt a specific fate." [GOC:go_curators]
synonym: "activation of cell fate specification" NARROW []
synonym: "stimulation of cell fate specification" NARROW []
synonym: "up regulation of cell fate specification" EXACT []
synonym: "up-regulation of cell fate specification" EXACT []
synonym: "upregulation of cell fate specification" EXACT []
is_a: GO:0010455 ! positive regulation of cell fate commitment
is_a: GO:0042659 ! regulation of cell fate specification
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001708 ! cell fate specification
relationship: positively_regulates GO:0001708 ! cell fate specification

[Term]
id: GO:0042661
name: regulation of mesodermal cell fate specification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesoderm cell fate specification." [GOC:go_curators]
is_a: GO:0010470 ! regulation of gastrulation
is_a: GO:0042659 ! regulation of cell fate specification
is_a: GO:2000027 ! regulation of organ morphogenesis
is_a: GO:2000380 ! regulation of mesoderm development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007501 ! mesodermal cell fate specification
relationship: regulates GO:0007501 ! mesodermal cell fate specification

[Term]
id: GO:0042662
name: negative regulation of mesodermal cell fate specification
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mesoderm cell fate specification." [GOC:go_curators]
synonym: "down regulation of mesodermal cell fate specification" EXACT []
synonym: "down-regulation of mesodermal cell fate specification" EXACT []
synonym: "downregulation of mesodermal cell fate specification" EXACT []
synonym: "inhibition of mesodermal cell fate specification" NARROW []
synonym: "suppression of mesodermal cell fate" EXACT []
is_a: GO:0009996 ! negative regulation of cell fate specification
is_a: GO:0042661 ! regulation of mesodermal cell fate specification
is_a: GO:2000381 ! negative regulation of mesoderm development
is_a: GO:2000542 ! negative regulation of gastrulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007501 ! mesodermal cell fate specification
relationship: negatively_regulates GO:0007501 ! mesodermal cell fate specification

[Term]
id: GO:0042663
name: regulation of endodermal cell fate specification
namespace: biological_process
def: "Any process that mediates the specification of a cell into an endoderm cell." [GOC:go_curators]
synonym: "regulation of endoderm cell fate specification" EXACT []
is_a: GO:0042659 ! regulation of cell fate specification
is_a: GO:1903224 ! regulation of endodermal cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001714 ! endodermal cell fate specification
relationship: regulates GO:0001714 ! endodermal cell fate specification

[Term]
id: GO:0042664
name: negative regulation of endodermal cell fate specification
namespace: biological_process
def: "Any process that restricts, stops or prevents a cell from specifying into an endoderm cell." [GOC:go_curators]
synonym: "down regulation of endodermal cell fate specification" EXACT []
synonym: "down-regulation of endodermal cell fate specification" EXACT []
synonym: "downregulation of endodermal cell fate specification" EXACT []
synonym: "inhibition of endodermal cell fate specification" NARROW []
synonym: "negative regulation of endoderm cell fate specification" EXACT []
synonym: "suppression of endoderm cell fate" EXACT []
synonym: "suppression of endodermal cell fate" EXACT []
is_a: GO:0009996 ! negative regulation of cell fate specification
is_a: GO:0042663 ! regulation of endodermal cell fate specification
is_a: GO:1903225 ! negative regulation of endodermal cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001714 ! endodermal cell fate specification
relationship: negatively_regulates GO:0001714 ! endodermal cell fate specification

[Term]
id: GO:0042665
name: regulation of ectodermal cell fate specification
namespace: biological_process
def: "Any process that mediates the specification of a cell into an ectoderm cell." [GOC:go_curators]
synonym: "regulation of ectoderm cell fate specification" EXACT []
is_a: GO:0010470 ! regulation of gastrulation
is_a: GO:0042659 ! regulation of cell fate specification
is_a: GO:2000383 ! regulation of ectoderm development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001715 ! ectodermal cell fate specification
relationship: regulates GO:0001715 ! ectodermal cell fate specification

[Term]
id: GO:0042666
name: negative regulation of ectodermal cell fate specification
namespace: biological_process
def: "Any process that restricts, stops or prevents a cell from specifying into an ectoderm cell." [GOC:go_curators]
synonym: "down regulation of ectodermal cell fate specification" EXACT []
synonym: "down-regulation of ectodermal cell fate specification" EXACT []
synonym: "downregulation of ectodermal cell fate specification" EXACT []
synonym: "inhibition of ectodermal cell fate specification" NARROW []
synonym: "negative regulation of ectoderm cell fate specification" EXACT []
synonym: "suppression of ectoderm cell fate" EXACT []
synonym: "suppression of ectodermal cell fate" EXACT []
is_a: GO:0009996 ! negative regulation of cell fate specification
is_a: GO:0042665 ! regulation of ectodermal cell fate specification
is_a: GO:2000384 ! negative regulation of ectoderm development
is_a: GO:2000542 ! negative regulation of gastrulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001715 ! ectodermal cell fate specification
relationship: negatively_regulates GO:0001715 ! ectodermal cell fate specification

[Term]
id: GO:0042667
name: auditory receptor cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into an auditory hair cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators]
synonym: "auditory hair cell fate specification" EXACT []
is_a: GO:0048665 ! neuron fate specification
relationship: part_of GO:0009912 ! auditory receptor cell fate commitment

[Term]
id: GO:0042668
name: auditory receptor cell fate determination
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into an auditory hair cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators]
synonym: "auditory hair cell fate determination" EXACT []
is_a: GO:0048664 ! neuron fate determination
relationship: part_of GO:0009912 ! auditory receptor cell fate commitment

[Term]
id: GO:0042669
name: regulation of auditory receptor cell fate specification
namespace: biological_process
def: "Any process that mediates the specification of a cell into an auditory hair cell." [GOC:go_curators]
synonym: "regulation of auditory hair cell fate specification" EXACT []
is_a: GO:0042659 ! regulation of cell fate specification
is_a: GO:0045607 ! regulation of auditory receptor cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042667 ! auditory receptor cell fate specification
relationship: regulates GO:0042667 ! auditory receptor cell fate specification

[Term]
id: GO:0042670
name: retinal cone cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a retinal cone cell." [GOC:go_curators]
is_a: GO:0060219 ! camera-type eye photoreceptor cell differentiation

[Term]
id: GO:0042671
name: retinal cone cell fate determination
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a retinal cone cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators]
is_a: GO:0043703 ! photoreceptor cell fate determination
relationship: part_of GO:0046551 ! retinal cone cell fate commitment

[Term]
id: GO:0042672
name: retinal cone cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a retinal cone cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators]
is_a: GO:0043704 ! photoreceptor cell fate specification
relationship: part_of GO:0046551 ! retinal cone cell fate commitment

[Term]
id: GO:0042673
name: regulation of retinal cone cell fate specification
namespace: biological_process
def: "Any process that mediates the specification of a cell into a retinal cone cell." [GOC:go_curators]
is_a: GO:0042659 ! regulation of cell fate specification
is_a: GO:0060222 ! regulation of retinal cone cell fate commitment
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042672 ! retinal cone cell fate specification
relationship: regulates GO:0042672 ! retinal cone cell fate specification

[Term]
id: GO:0042675
name: compound eye cone cell differentiation
namespace: biological_process
alt_id: GO:0042674
def: "The process in which a relatively unspecialized cell acquires the specialized features of a compound eye cone cell, a cone-shaped cell, that focuses light in a compound eye." [GOC:mtg_sensu]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0001745 ! compound eye morphogenesis

[Term]
id: GO:0042676
name: compound eye cone cell fate commitment
namespace: biological_process
alt_id: GO:0007466
def: "The process in which the cone cells of the compound eye, the lens-secreting cells in the ommatidia, adopt pathways of differentiation that lead to the establishment of their distinct cell type." [GOC:mtg_sensu]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0042675 ! compound eye cone cell differentiation

[Term]
id: GO:0042679
name: compound eye cone cell fate specification
namespace: biological_process
alt_id: GO:0042678
def: "The process in which a cell becomes capable of differentiating autonomously into a compound eye cone cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:mtg_sensu]
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0042676 ! compound eye cone cell fate commitment

[Term]
id: GO:0042680
name: compound eye cone cell fate determination
namespace: biological_process
alt_id: GO:0042677
def: "The process in which a cell becomes capable of differentiating autonomously into a compound eye cone cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:mtg_sensu]
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0042676 ! compound eye cone cell fate commitment

[Term]
id: GO:0042682
name: regulation of compound eye cone cell fate specification
namespace: biological_process
alt_id: GO:0042681
def: "Any process that mediates the specification of a cell into a compound eye cone cell." [GOC:mtg_sensu]
is_a: GO:0042659 ! regulation of cell fate specification
is_a: GO:2000027 ! regulation of organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042679 ! compound eye cone cell fate specification
relationship: regulates GO:0042679 ! compound eye cone cell fate specification

[Term]
id: GO:0042683
name: negative regulation of compound eye cone cell fate specification
namespace: biological_process
alt_id: GO:0010000
def: "Any process that restricts, stops or prevents a cell from specifying into a compound eye cone cell." [GOC:mtg_sensu]
synonym: "down regulation of cone cell fate specification" BROAD []
synonym: "down-regulation of cone cell fate specification" BROAD []
synonym: "downregulation of cone cell fate specification" BROAD []
synonym: "inhibition of cone cell fate specification" BROAD []
synonym: "suppression of cone cell fate" BROAD []
is_a: GO:0009996 ! negative regulation of cell fate specification
is_a: GO:0042682 ! regulation of compound eye cone cell fate specification
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042679 ! compound eye cone cell fate specification
relationship: negatively_regulates GO:0042679 ! compound eye cone cell fate specification

[Term]
id: GO:0042684
name: cardioblast cell fate commitment
namespace: biological_process
def: "The process in which a cell becomes committed to becoming a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators]
is_a: GO:0060911 ! cardiac cell fate commitment
relationship: part_of GO:0010002 ! cardioblast differentiation

[Term]
id: GO:0042685
name: cardioblast cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a cardioblast cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators]
is_a: GO:0060912 ! cardiac cell fate specification
relationship: part_of GO:0042684 ! cardioblast cell fate commitment

[Term]
id: GO:0042686
name: regulation of cardioblast cell fate specification
namespace: biological_process
def: "Any process that mediates the specification of a cell into a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators]
is_a: GO:0051890 ! regulation of cardioblast differentiation
is_a: GO:2000043 ! regulation of cardiac cell fate specification
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042685 ! cardioblast cell fate specification
relationship: regulates GO:0042685 ! cardioblast cell fate specification

[Term]
id: GO:0042688
name: crystal cell differentiation
namespace: biological_process
def: "The process in which a hemocyte precursor cell acquires the characteristics of a crystal cell, a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph." [GOC:bf, http://sdb.bio.purdue.edu/fly/gene/serpent3.htm]
is_a: GO:0042386 ! hemocyte differentiation

[Term]
id: GO:0042689
name: regulation of crystal cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of crystal cell differentiation." [GOC:go_curators]
is_a: GO:0045610 ! regulation of hemocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042688 ! crystal cell differentiation
relationship: regulates GO:0042688 ! crystal cell differentiation

[Term]
id: GO:0042690
name: negative regulation of crystal cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of crystal cell differentiation." [GOC:go_curators]
synonym: "down regulation of crystal cell differentiation" EXACT []
synonym: "down-regulation of crystal cell differentiation" EXACT []
synonym: "downregulation of crystal cell differentiation" EXACT []
synonym: "inhibition of crystal cell differentiation" NARROW []
is_a: GO:0042689 ! regulation of crystal cell differentiation
is_a: GO:0045611 ! negative regulation of hemocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042688 ! crystal cell differentiation
relationship: negatively_regulates GO:0042688 ! crystal cell differentiation

[Term]
id: GO:0042691
name: positive regulation of crystal cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of crystal cell differentiation." [GOC:go_curators]
synonym: "activation of crystal cell differentiation" NARROW []
synonym: "stimulation of crystal cell differentiation" NARROW []
synonym: "up regulation of crystal cell differentiation" EXACT []
synonym: "up-regulation of crystal cell differentiation" EXACT []
synonym: "upregulation of crystal cell differentiation" EXACT []
is_a: GO:0042689 ! regulation of crystal cell differentiation
is_a: GO:0045612 ! positive regulation of hemocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042688 ! crystal cell differentiation
relationship: positively_regulates GO:0042688 ! crystal cell differentiation

[Term]
id: GO:0042692
name: muscle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a muscle cell." [CL:0000187, GOC:go_curators]
xref: Reactome:REACT_109683 "Myogenesis, Rattus norvegicus"
xref: Reactome:REACT_113484 "Myogenesis, Caenorhabditis elegans"
xref: Reactome:REACT_21303 "Myogenesis, Homo sapiens"
xref: Reactome:REACT_32665 "Myogenesis, Danio rerio"
xref: Reactome:REACT_34056 "Myogenesis, Canis familiaris"
xref: Reactome:REACT_77596 "Myogenesis, Sus scrofa"
xref: Reactome:REACT_84060 "Myogenesis, Gallus gallus"
xref: Reactome:REACT_84715 "Myogenesis, Drosophila melanogaster"
xref: Reactome:REACT_85310 "Myogenesis, Taeniopygia guttata"
xref: Reactome:REACT_90630 "Myogenesis, Bos taurus"
xref: Reactome:REACT_95727 "Myogenesis, Mus musculus"
xref: Reactome:REACT_95839 "Myogenesis, Xenopus tropicalis"
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0061061 ! muscle structure development

[Term]
id: GO:0042693
name: muscle cell fate commitment
namespace: biological_process
def: "The process in which the cellular identity of muscle cells is acquired and determined." [CL:0000187, GOC:go_curators]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0042692 ! muscle cell differentiation

[Term]
id: GO:0042694
name: muscle cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a muscle cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [CL:0000187, GOC:go_curators]
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0042693 ! muscle cell fate commitment

[Term]
id: GO:0042695
name: thelarche
namespace: biological_process
def: "The beginning of development of the breasts in the female." [GOC:curators, PMID:19117864]
xref: Wikipedia:Thelarche
is_a: GO:0046543 ! development of secondary female sexual characteristics
relationship: part_of GO:0030879 ! mammary gland development

[Term]
id: GO:0042696
name: menarche
namespace: biological_process
def: "The beginning of the menstrual cycle; the first menstrual cycle in an individual." [GOC:curators, PMID:16311040]
subset: gocheck_do_not_annotate
xref: Wikipedia:Menarche
is_a: GO:0022601 ! menstrual cycle phase

[Term]
id: GO:0042697
name: menopause
namespace: biological_process
def: "Cessation of menstruation, occurring in (e.g.) the human female usually around the age of 50." [GOC:curators, PMID:18495681]
subset: gocheck_do_not_annotate
xref: Wikipedia:Menopause
is_a: GO:0022601 ! menstrual cycle phase
relationship: part_of GO:0010259 ! multicellular organism aging

[Term]
id: GO:0042698
name: ovulation cycle
namespace: biological_process
def: "The type of sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years." [ISBN:0721662544]
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0048511 ! rhythmic process
is_a: GO:0048609 ! multicellular organismal reproductive process

[Term]
id: GO:0042699
name: follicle-stimulating hormone signaling pathway
namespace: biological_process
def: "The series of molecular signals mediated by follicle-stimulating hormone." [GOC:dph]
synonym: "follicle stimulating hormone signaling pathway" EXACT []
synonym: "follicle stimulating hormone signalling pathway" EXACT []
synonym: "follicle-stimulating hormone signalling pathway" EXACT []
is_a: GO:0007186 ! G-protein coupled receptor signaling pathway
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0022602 ! ovulation cycle process
relationship: part_of GO:0001541 ! ovarian follicle development

[Term]
id: GO:0042700
name: luteinizing hormone signaling pathway
namespace: biological_process
def: "The series of molecular signals mediated by luteinizing hormone." [GOC:dph]
synonym: "luteinizing hormone signalling pathway" EXACT []
is_a: GO:0007186 ! G-protein coupled receptor signaling pathway

[Term]
id: GO:0042701
name: progesterone secretion
namespace: biological_process
def: "The regulated release of progesterone, a steroid hormone, by the corpus luteum of the ovary and by the placenta." [GOC:jl, ISBN:0395825172]
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0022602 ! ovulation cycle process
is_a: GO:0035929 ! steroid hormone secretion
relationship: part_of GO:0001553 ! luteinization

[Term]
id: GO:0042702
name: uterine wall growth
namespace: biological_process
def: "The regrowth of the endometrium and blood vessels in the uterus following menstruation, resulting from a rise in progesterone levels." [GOC:jl]
is_a: GO:0022602 ! ovulation cycle process
is_a: GO:0040007 ! growth
relationship: part_of GO:0001553 ! luteinization

[Term]
id: GO:0042703
name: menstruation
namespace: biological_process
def: "The cyclic, physiologic discharge through the vagina of blood and endometrial tissues from the nonpregnant uterus." [GOC:curators, PMID:8693059]
subset: gocheck_do_not_annotate
xref: Wikipedia:Menstruation
is_a: GO:0022601 ! menstrual cycle phase

[Term]
id: GO:0042704
name: uterine wall breakdown
namespace: biological_process
def: "The sloughing of the endometrium and blood vessels during menstruation that results from a drop in progesterone levels." [GOC:dph]
is_a: GO:0022602 ! ovulation cycle process
relationship: happens_during GO:0042703 ! menstruation

[Term]
id: GO:0042705
name: ocellus photoreceptor cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a photoreceptor cell found in the ocellus." [GOC:go_curators]
is_a: GO:0046530 ! photoreceptor cell differentiation

[Term]
id: GO:0042706
name: eye photoreceptor cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into an eye photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments." [GOC:mtg_sensu]
is_a: GO:0046552 ! photoreceptor cell fate commitment
relationship: part_of GO:0001754 ! eye photoreceptor cell differentiation

[Term]
id: GO:0042707
name: ocellus photoreceptor cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into photoreceptor cell in the ocellus. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments." [GOC:mtg_sensu]
is_a: GO:0046552 ! photoreceptor cell fate commitment
relationship: part_of GO:0042705 ! ocellus photoreceptor cell differentiation

[Term]
id: GO:0042708
name: obsolete elastase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of elastin." [ISBN:0198506732]
comment: This term was made obsolete because it represents a gene product.
synonym: "elastase activity" EXACT []
is_obsolete: true
replaced_by: GO:0004175

[Term]
id: GO:0042709
name: succinate-CoA ligase complex
namespace: cellular_component
def: "A heterodimeric enzyme complex, usually composed of an alpha and beta chain. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP or GTP." [EC:6.2.1.4, EC:6.2.1.5, GOC:jl]
subset: gosubset_prok
is_a: GO:0045239 ! tricarboxylic acid cycle enzyme complex
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0042710
name: biofilm formation
namespace: biological_process
def: "A process in which planktonically growing microorganisms grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription." [GOC:di, PMID:11932229]
subset: gocheck_do_not_annotate
subset: gocheck_do_not_manually_annotate
subset: goslim_candida
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0044764 ! multi-organism cellular process

[Term]
id: GO:0042711
name: maternal behavior
namespace: biological_process
def: "Female behaviors associated with the care and rearing of offspring." [GOC:curators]
synonym: "maternal behaviour" EXACT []
is_a: GO:0060746 ! parental behavior

[Term]
id: GO:0042712
name: paternal behavior
namespace: biological_process
def: "Male behaviors associated with the care and rearing offspring." [GOC:go_curators]
synonym: "paternal behaviour" EXACT []
is_a: GO:0060746 ! parental behavior

[Term]
id: GO:0042713
name: sperm ejaculation
namespace: biological_process
def: "The expulsion of seminal fluid, thick white fluid containing spermatozoa, from the male genital tract." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0048609 ! multicellular organismal reproductive process
relationship: part_of GO:0007320 ! insemination

[Term]
id: GO:0042714
name: dosage compensation complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins on DNA or RNA to form the complex that mediates dosage compensation on one or more X chromosomes." [GOC:jl, PMID:11102361, PMID:12672493]
is_a: GO:0034622 ! cellular macromolecular complex assembly
relationship: part_of GO:0007549 ! dosage compensation

[Term]
id: GO:0042715
name: dosage compensation complex assembly involved in dosage compensation by hypoactivation of X chromosome
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins on DNA to form the complex that mediates dosage compensation on both X chromosomes in the monogametic sex, ultimately resulting in a two-fold reduction in transcription from these chromosomes. An example of this process is found in Caenorhabditis elegans." [GOC:jl, PMID:11102361, PMID:12672493]
synonym: "dosage compensation complex assembly during dosage compensation by hypoactivation of X chromosome" RELATED [GOC:dph, GOC:tb]
is_a: GO:0042714 ! dosage compensation complex assembly
is_a: GO:0065004 ! protein-DNA complex assembly
intersection_of: GO:0042714 ! dosage compensation complex assembly
intersection_of: part_of GO:0042464 ! dosage compensation by hypoactivation of X chromosome
relationship: part_of GO:0042464 ! dosage compensation by hypoactivation of X chromosome

[Term]
id: GO:0042716
name: plasma membrane-derived chromatophore
namespace: cellular_component
def: "A pigment-bearing structure that is derived from the cytoplasmic membrane, sometimes consisting of simple invaginations and sometimes a complete vesicle. This component is found in certain photosynthetic bacteria and cyanobacteria." [GOC:jl, ISBN:0395825172, PMID:11867431]
comment: Note that this structure is distinct from the chromoplast of plants, which is also sometimes called a chromatophore; it also should not be confused with the specialized pigment-producing cells known as chromatophores, found in fish and amphibian skin.
subset: gosubset_prok
synonym: "chromatophore vesicle" RELATED []
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0042717
name: plasma membrane-derived chromatophore membrane
namespace: cellular_component
def: "The lipid bilayer associated with a plasma membrane-derived chromatophore; surrounds chromatophores that form complete vesicles." [GOC:jl, GOC:mah, ISBN:0395825172, PMID:11867431]
subset: gosubset_prok
is_a: GO:0034357 ! photosynthetic membrane
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0042716 ! plasma membrane-derived chromatophore

[Term]
id: GO:0042718
name: yolk granule
namespace: cellular_component
def: "Discrete structures that partition the water-insoluble portion of the yolk of oocytes and ova, which may or may not be membrane enclosed." [GOC:jl, http://148.216.10.83/cellbio/eggs.htm, PMID:18046696]
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0060417 ! yolk

[Term]
id: GO:0042719
name: mitochondrial intermembrane space protein transporter complex
namespace: cellular_component
def: "Soluble complex of the mitochondrial intermembrane space composed of various combinations of small Tim proteins; acts as a protein transporter to guide proteins to the Tim22 complex for insertion into the mitochondrial inner membrane." [PMID:12581629]
synonym: "Tim9-Tim10 complex" NARROW []
is_a: GO:0098798 ! mitochondrial protein complex
is_a: GO:1990351 ! transporter complex
relationship: part_of GO:0005758 ! mitochondrial intermembrane space

[Term]
id: GO:0042720
name: mitochondrial inner membrane peptidase complex
namespace: cellular_component
def: "Protease complex of the mitochondrial inner membrane, consisting of at least two subunits, involved in processing of both nuclear- and mitochondrially-encoded proteins targeted to the intermembrane space." [PMID:10821182, PMID:12191769]
synonym: "IMP" NARROW []
is_a: GO:0098800 ! inner mitochondrial membrane protein complex
relationship: part_of GO:0005743 ! mitochondrial inner membrane

[Term]
id: GO:0042721
name: mitochondrial inner membrane protein insertion complex
namespace: cellular_component
def: "A multi-subunit complex embedded in the mitochondrial inner membrane that mediates insertion of carrier proteins into the inner membrane." [PMID:12191765]
synonym: "Tim22 complex" NARROW []
is_a: GO:0098800 ! inner mitochondrial membrane protein complex
relationship: part_of GO:0005743 ! mitochondrial inner membrane

[Term]
id: GO:0042722
name: alpha-beta T cell activation by superantigen
namespace: biological_process
def: "The change in morphology and behavior of alpha-beta T cells resulting from exposure to a superantigen, a microbial antigen with an extremely potent activating effect on T cells that bear a specific variable region." [GOC:jl]
synonym: "alpha-beta T lymphocyte activation by superantigen" EXACT []
synonym: "alpha-beta T-cell activation by superantigen" EXACT []
synonym: "alpha-beta T-lymphocyte activation by superantigen" EXACT []
is_a: GO:0046631 ! alpha-beta T cell activation

[Term]
id: GO:0042723
name: thiamine-containing compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving thiamine (vitamin B1), and compounds derived from it." [CHEBI:26948, GOC:jl]
subset: gosubset_prok
synonym: "thiamin and derivative metabolic process" EXACT [GOC:curators]
synonym: "thiamin and derivative metabolism" EXACT []
synonym: "thiamin-containing compound metabolic process" EXACT [GOC:curators]
synonym: "thiamine and derivative metabolic process" EXACT []
synonym: "thiamine and derivative metabolism" EXACT []
synonym: "thiamine-containing compound metabolism" EXACT [GOC:curators]
synonym: "vitamin B1 and derivative metabolic process" EXACT []
synonym: "vitamin B1 and derivative metabolism" EXACT []
xref: Reactome:REACT_104842 "Vitamin B1 (thiamin) metabolism, Caenorhabditis elegans"
xref: Reactome:REACT_107585 "Vitamin B1 (thiamin) metabolism, Dictyostelium discoideum"
xref: Reactome:REACT_107765 "Vitamin B1 (thiamin) metabolism, Canis familiaris"
xref: Reactome:REACT_109860 "Vitamin B1 (thiamin) metabolism, Mus musculus"
xref: Reactome:REACT_11117 "Vitamin B1 (thiamin) metabolism, Homo sapiens"
xref: Reactome:REACT_29199 "Vitamin B1 (thiamin) metabolism, Plasmodium falciparum"
xref: Reactome:REACT_29785 "Vitamin B1 (thiamin) metabolism, Rattus norvegicus"
xref: Reactome:REACT_79564 "Vitamin B1 (thiamin) metabolism, Xenopus tropicalis"
xref: Reactome:REACT_79734 "Vitamin B1 (thiamin) metabolism, Drosophila melanogaster"
xref: Reactome:REACT_80776 "Vitamin B1 (thiamin) metabolism, Arabidopsis thaliana"
xref: Reactome:REACT_81212 "Vitamin B1 (thiamin) metabolism, Oryza sativa"
xref: Reactome:REACT_82041 "Vitamin B1 (thiamin) metabolism, Taeniopygia guttata"
xref: Reactome:REACT_83032 "Vitamin B1 (thiamin) metabolism, Sus scrofa"
xref: Reactome:REACT_85593 "Vitamin B1 (thiamin) metabolism, Gallus gallus"
xref: Reactome:REACT_92636 "Vitamin B1 (thiamin) metabolism, Danio rerio"
xref: Reactome:REACT_94652 "Vitamin B1 (thiamin) metabolism, Bos taurus"
xref: Reactome:REACT_99932 "Vitamin B1 (thiamin) metabolism, Saccharomyces cerevisiae"
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0006767 ! water-soluble vitamin metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0072527 ! pyrimidine-containing compound metabolic process

[Term]
id: GO:0042724
name: thiamine-containing compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), and related compounds." [CHEBI:26948, GOC:jl]
subset: gosubset_prok
synonym: "thiamin and derivative biosynthesis" EXACT []
synonym: "thiamin and derivative biosynthetic process" EXACT [GOC:curators]
synonym: "thiamin-containing compound biosynthetic process" EXACT [GOC:curators]
synonym: "thiamine and derivative biosynthesis" EXACT []
synonym: "thiamine and derivative biosynthetic process" EXACT []
synonym: "thiamine-containing compound anabolism" EXACT [GOC:curators]
synonym: "thiamine-containing compound biosynthesis" EXACT [GOC:curators]
synonym: "thiamine-containing compound formation" EXACT [GOC:curators]
synonym: "thiamine-containing compound synthesis" EXACT [GOC:curators]
synonym: "vitamin B1 and derivative biosynthesis" EXACT []
synonym: "vitamin B1 and derivative biosynthetic process" EXACT []
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0042364 ! water-soluble vitamin biosynthetic process
is_a: GO:0042723 ! thiamine-containing compound metabolic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:0072528 ! pyrimidine-containing compound biosynthetic process

[Term]
id: GO:0042725
name: thiamine-containing compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of thiamine (vitamin B1), and compounds derived from it." [CHEBI:26948, GOC:jl]
subset: gosubset_prok
synonym: "thiamin and derivative catabolic process" EXACT [GOC:curators]
synonym: "thiamin and derivative catabolism" EXACT []
synonym: "thiamin-containing compound catabolic process" EXACT [GOC:curators]
synonym: "thiamine and derivative catabolic process" EXACT []
synonym: "thiamine and derivative catabolism" EXACT []
synonym: "thiamine-containing compound breakdown" EXACT [GOC:curators]
synonym: "thiamine-containing compound catabolism" EXACT [GOC:curators]
synonym: "thiamine-containing compound degradation" EXACT [GOC:curators]
synonym: "vitamin B1 and derivative catabolic process" EXACT []
synonym: "vitamin B1 and derivative catabolism" EXACT []
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042365 ! water-soluble vitamin catabolic process
is_a: GO:0042723 ! thiamine-containing compound metabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0072529 ! pyrimidine-containing compound catabolic process

[Term]
id: GO:0042726
name: flavin-containing compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a flavin, any derivative of the dimethylisoalloxazine (7,8-dimethylbenzo[g]pteridine-2,4(3H,10H)-dione) skeleton, with a substituent on the 10 position." [CHEBI:30527, GOC:jl, GOC:mah]
subset: gosubset_prok
synonym: "flavin-containing compound metabolism" EXACT [GOC:curators]
synonym: "riboflavin and derivative metabolic process" RELATED [GOC:curators]
synonym: "riboflavin and derivative metabolism" RELATED [GOC:curators]
synonym: "vitamin B2 and derivative metabolic process" RELATED [GOC:curators]
synonym: "vitamin B2 and derivative metabolism" RELATED [GOC:curators]
is_a: GO:0034641 ! cellular nitrogen compound metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process

[Term]
id: GO:0042727
name: flavin-containing compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a flavin, any derivative of the dimethylisoalloxazine (7,8-dimethylbenzo[g]pteridine-2,4(3H,10H)-dione) skeleton, with a substituent on the 10 position." [CHEBI:30527, GOC:jl, GOC:mah]
subset: gosubset_prok
synonym: "flavin-containing compound anabolism" EXACT [GOC:curators]
synonym: "flavin-containing compound biosynthesis" EXACT [GOC:curators]
synonym: "flavin-containing compound formation" EXACT [GOC:curators]
synonym: "flavin-containing compound synthesis" EXACT [GOC:curators]
synonym: "riboflavin and derivative biosynthesis" RELATED [GOC:curators]
synonym: "riboflavin and derivative biosynthetic process" RELATED [GOC:curators]
synonym: "vitamin B2 and derivative biosynthesis" RELATED [GOC:curators]
synonym: "vitamin B2 and derivative biosynthetic process" RELATED [GOC:curators]
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0042726 ! flavin-containing compound metabolic process
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process

[Term]
id: GO:0042728
name: flavin-containing compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a flavin, any derivative of the dimethylisoalloxazine (7,8-dimethylbenzo[g]pteridine-2,4(3H,10H)-dione) skeleton, with a substituent on the 10 position." [CHEBI:30527, GOC:jl, GOC:mah]
subset: gosubset_prok
synonym: "flavin-containing compound catabolic process breakdown" EXACT [GOC:curators]
synonym: "flavin-containing compound catabolic process degradation" EXACT [GOC:curators]
synonym: "flavin-containing compound catabolism" EXACT [GOC:curators]
synonym: "riboflavin and derivative catabolic process" RELATED [GOC:curators]
synonym: "riboflavin and derivative catabolism" RELATED [GOC:curators]
synonym: "vitamin B2 and derivative catabolic process" RELATED [GOC:curators]
synonym: "vitamin B2 and derivative catabolism" RELATED [GOC:curators]
is_a: GO:0042726 ! flavin-containing compound metabolic process
is_a: GO:0044270 ! cellular nitrogen compound catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process

[Term]
id: GO:0042729
name: DASH complex
namespace: cellular_component
alt_id: GO:0043925
alt_id: GO:0043926
def: "A large protein complex, containing around 8-10 subunits in yeast, including Duo1p, Dam1p, Dad1p and Ask1p. The complex forms part of the kinetochore, associates with microtubules when the kinetochore attaches to the spindle, and plays a role in spindle attachment, chromosome segregation and spindle stability." [GOC:jl, GOC:vw, http://www.wikigenes.org/e/gene/e/853090.html, PMID:11782438, PMID:11799062, PMID:15632076, PMID:15640796]
comment: Note that this complex is conserved in fungi but has not been observed in metazoans.
synonym: "condensed nuclear chromosome kinetochore-associated DASH complex" EXACT []
synonym: "Dam1 complex" EXACT []
synonym: "DDD complex" EXACT []
synonym: "Duo1p-Dam1p-Dad1p complex" EXACT []
is_a: GO:0000942 ! condensed nuclear chromosome outer kinetochore

[Term]
id: GO:0042730
name: fibrinolysis
namespace: biological_process
def: "A process that solubilizes fibrin in the bloodstream of a multicellular organism, chiefly by the proteolytic action of plasmin." [GOC:jl, PMID:15842654]
xref: Reactome:REACT_104553 "Dissolution of Fibrin Clot, Xenopus tropicalis"
xref: Reactome:REACT_108773 "Dissolution of Fibrin Clot, Bos taurus"
xref: Reactome:REACT_109620 "Dissolution of Fibrin Clot, Gallus gallus"
xref: Reactome:REACT_110142 "Dissolution of Fibrin Clot, Taeniopygia guttata"
xref: Reactome:REACT_110565 "Dissolution of Fibrin Clot, Mus musculus"
xref: Reactome:REACT_28581 "Dissolution of Fibrin Clot, Sus scrofa"
xref: Reactome:REACT_31032 "Dissolution of Fibrin Clot, Rattus norvegicus"
xref: Reactome:REACT_641 "Dissolution of Fibrin Clot, Homo sapiens"
xref: Reactome:REACT_82914 "Dissolution of Fibrin Clot, Canis familiaris"
xref: Reactome:REACT_86728 "Dissolution of Fibrin Clot, Danio rerio"
xref: Wikipedia:Fibrinolysis
is_a: GO:0030195 ! negative regulation of blood coagulation

[Term]
id: GO:0042731
name: PH domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a PH domain (pleckstrin homology) of a protein, a domain of about 100 residues that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton." [GOC:jl, Pfam:PF00169]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0042732
name: D-xylose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-xylose, a naturally occurring plant polysaccharide." [ISBN:0198506732]
subset: gosubset_prok
synonym: "D-xylose metabolism" EXACT []
is_a: GO:0019321 ! pentose metabolic process

[Term]
id: GO:0042733
name: embryonic digit morphogenesis
namespace: biological_process
def: "The process, occurring in the embryo, by which the anatomical structures of the digit are generated and organized. A digit is one of the terminal divisions of an appendage, such as a finger or toe." [GOC:bf, GOC:jl, UBERON:0002544]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0030326 ! embryonic limb morphogenesis

[Term]
id: GO:0042734
name: presynaptic membrane
namespace: cellular_component
def: "A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane." [GOC:jl, ISBN:0815316194]
subset: goslim_synapse
synonym: "pre-synaptic membrane" EXACT []
is_a: GO:0097060 ! synaptic membrane
is_a: GO:0097458 ! neuron part
relationship: part_of GO:0098793 ! presynapse

[Term]
id: GO:0042735
name: protein body
namespace: cellular_component
def: "A membrane-bounded plant organelle found in the developing endosperm, contains storage proteins." [GOC:jl, PMID:7704047]
is_a: GO:0043231 ! intracellular membrane-bounded organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0042736
name: NADH kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + NADH = ADP + 2 H(+) + NADPH." [EC:2.7.1.86, RHEA:12263]
synonym: "ATP:NADH 2'-phosphotransferase activity" EXACT [EC:2.7.1.86]
synonym: "DPNH kinase activity" EXACT [EC:2.7.1.86]
synonym: "reduced diphosphopyridine nucleotide kinase activity" EXACT [EC:2.7.1.86]
synonym: "reduced nicotinamide adenine dinucleotide kinase (phosphorylating)" EXACT [EC:2.7.1.86]
xref: EC:2.7.1.86
xref: KEGG:R00105
xref: MetaCyc:NADH-KINASE-RXN
xref: RHEA:12263
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0042737
name: drug catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a drug, a substance used in the diagnosis, treatment or prevention of a disease." [GOC:go_curators]
subset: gosubset_prok
synonym: "drug breakdown" EXACT []
synonym: "drug catabolism" EXACT []
synonym: "drug degradation" EXACT []
is_a: GO:0017144 ! drug metabolic process
is_a: GO:0044248 ! cellular catabolic process

[Term]
id: GO:0042738
name: exogenous drug catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a drug that has originated externally to the cell or organism." [GOC:jl]
subset: gosubset_prok
synonym: "exogenous drug breakdown" EXACT []
synonym: "exogenous drug catabolism" EXACT []
synonym: "exogenous drug degradation" EXACT []
is_a: GO:0042737 ! drug catabolic process
relationship: part_of GO:0042493 ! response to drug

[Term]
id: GO:0042739
name: endogenous drug catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a drug that has originated internally within the cell or organism." [GOC:jl]
subset: gosubset_prok
synonym: "endogenous drug breakdown" EXACT []
synonym: "endogenous drug catabolism" EXACT []
synonym: "endogenous drug degradation" EXACT []
is_a: GO:0042737 ! drug catabolic process

[Term]
id: GO:0042740
name: exogenous antibiotic catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of an antibiotic that has originated externally to the cell or organism." [GOC:jl]
subset: gosubset_prok
synonym: "exogenous antibiotic breakdown" EXACT []
synonym: "exogenous antibiotic catabolism" EXACT []
synonym: "exogenous antibiotic degradation" EXACT []
is_a: GO:0017001 ! antibiotic catabolic process
is_a: GO:0042738 ! exogenous drug catabolic process
relationship: part_of GO:0046677 ! response to antibiotic

[Term]
id: GO:0042741
name: endogenous antibiotic catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of an antibiotic that has originated internally within the cell or organism." [GOC:jl]
subset: gosubset_prok
synonym: "endogenous antibiotic breakdown" EXACT []
synonym: "endogenous antibiotic catabolism" EXACT []
synonym: "endogenous antibiotic degradation" EXACT []
is_a: GO:0017001 ! antibiotic catabolic process
is_a: GO:0042739 ! endogenous drug catabolic process

[Term]
id: GO:0042742
name: defense response to bacterium
namespace: biological_process
alt_id: GO:0042830
def: "Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl]
subset: gosubset_prok
synonym: "antibacterial peptide activity" RELATED []
synonym: "defence response to bacteria" EXACT []
synonym: "defence response to bacterium" EXACT []
synonym: "defense response to bacteria" EXACT []
is_a: GO:0009617 ! response to bacterium
is_a: GO:0098542 ! defense response to other organism

[Term]
id: GO:0042743
name: hydrogen peroxide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA." [GOC:jl, http://biotech.icmb.utexas.edu/]
subset: gosubset_prok
synonym: "H2O2 metabolic process" EXACT [GOC:mah]
synonym: "hydrogen peroxide metabolism" EXACT []
is_a: GO:0072593 ! reactive oxygen species metabolic process

[Term]
id: GO:0042744
name: hydrogen peroxide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2)." [GOC:jl]
subset: gosubset_prok
synonym: "detoxification of H2O2" RELATED [GOC:vw]
synonym: "detoxification of hydrogen peroxide" RELATED [GOC:vw]
synonym: "H2O2 catabolic process" EXACT [GOC:mah]
synonym: "H2O2 scavenging" RELATED [GOC:vw]
synonym: "hydrogen peroxide breakdown" EXACT []
synonym: "hydrogen peroxide catabolism" EXACT []
synonym: "hydrogen peroxide degradation" EXACT []
synonym: "hydrogen peroxide removal" RELATED []
synonym: "hydrogen peroxide scavenging" RELATED [GOC:vw]
is_a: GO:0042743 ! hydrogen peroxide metabolic process
is_a: GO:0044248 ! cellular catabolic process
is_a: GO:0044712 ! single-organism catabolic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0042745
name: circadian sleep/wake cycle
namespace: biological_process
def: "The cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm." [GOC:jl, http://www.sleepquest.com]
is_a: GO:0048512 ! circadian behavior

[Term]
id: GO:0042746
name: circadian sleep/wake cycle, wakefulness
namespace: biological_process
def: "The part of the circadian sleep/wake cycle where the organism is not asleep." [GOC:jl, PMID:12575468]
is_a: GO:0022410 ! circadian sleep/wake cycle process

[Term]
id: GO:0042747
name: circadian sleep/wake cycle, REM sleep
namespace: biological_process
def: "A stage in the circadian sleep cycle during which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity." [GOC:jl, ISBN:0395825172]
is_a: GO:0022410 ! circadian sleep/wake cycle process
relationship: part_of GO:0050802 ! circadian sleep/wake cycle, sleep

[Term]
id: GO:0042748
name: circadian sleep/wake cycle, non-REM sleep
namespace: biological_process
def: "All sleep stages in the circadian sleep/wake cycle other than REM sleep. These stages are characterized by a slowing of brain waves and other physiological functions." [GOC:jl, http://www.sleepquest.com]
is_a: GO:0022410 ! circadian sleep/wake cycle process
relationship: part_of GO:0050802 ! circadian sleep/wake cycle, sleep

[Term]
id: GO:0042749
name: regulation of circadian sleep/wake cycle
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the circadian sleep/wake cycle." [GOC:jl]
is_a: GO:0042752 ! regulation of circadian rhythm
is_a: GO:0050795 ! regulation of behavior
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042745 ! circadian sleep/wake cycle
relationship: regulates GO:0042745 ! circadian sleep/wake cycle

[Term]
id: GO:0042750
name: hibernation
namespace: biological_process
def: "Any process in which an organism enters and maintains a period of dormancy in which to pass the winter. It is characterized by narcosis and by sharp reduction in body temperature and metabolic activity and by a depression of vital signs." [GOC:jl, PMID:1945046]
xref: Wikipedia:Hibernation
is_a: GO:0022611 ! dormancy process
is_a: GO:0030431 ! sleep
is_a: GO:0044767 ! single-organism developmental process

[Term]
id: GO:0042751
name: estivation
namespace: biological_process
def: "Any process in which an organism enters and maintains a period of dormancy, similar to hibernation, but that occurs during the summer. It insulates against heat to prevent the harmful effects of the season." [GOC:jl, PMID:12443930, Wikipedia:Estivation]
synonym: "aestivation" EXACT [GOC:pr]
xref: Wikipedia:Estivation
is_a: GO:0022611 ! dormancy process
is_a: GO:0030431 ! sleep
is_a: GO:0044767 ! single-organism developmental process

[Term]
id: GO:0042752
name: regulation of circadian rhythm
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:dph, GOC:jl, GOC:tb]
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007623 ! circadian rhythm
relationship: regulates GO:0007623 ! circadian rhythm

[Term]
id: GO:0042753
name: positive regulation of circadian rhythm
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a circadian rhythm behavior." [GOC:go_curators]
synonym: "activation of circadian rhythm" NARROW []
synonym: "stimulation of circadian rhythm" NARROW []
synonym: "up regulation of circadian rhythm" EXACT []
synonym: "up-regulation of circadian rhythm" EXACT []
synonym: "upregulation of circadian rhythm" EXACT []
is_a: GO:0042752 ! regulation of circadian rhythm
is_a: GO:0048518 ! positive regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007623 ! circadian rhythm
relationship: positively_regulates GO:0007623 ! circadian rhythm

[Term]
id: GO:0042754
name: negative regulation of circadian rhythm
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a circadian rhythm behavior." [GOC:go_curators]
synonym: "down regulation of circadian rhythm" EXACT []
synonym: "down-regulation of circadian rhythm" EXACT []
synonym: "downregulation of circadian rhythm" EXACT []
synonym: "inhibition of circadian rhythm" NARROW []
is_a: GO:0042752 ! regulation of circadian rhythm
is_a: GO:0048519 ! negative regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007623 ! circadian rhythm
relationship: negatively_regulates GO:0007623 ! circadian rhythm

[Term]
id: GO:0042755
name: eating behavior
namespace: biological_process
def: "The specific behavior of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue." [GOC:jl, GOC:pr, ISBN:01928006X]
synonym: "eating behaviour" EXACT []
is_a: GO:0007631 ! feeding behavior

[Term]
id: GO:0042756
name: drinking behavior
namespace: biological_process
def: "The specific behavior of an organism relating to the intake of liquids, especially water." [GOC:curators, GOC:pr]
synonym: "drinking behaviour" EXACT []
is_a: GO:0007631 ! feeding behavior

[Term]
id: GO:0042757
name: giant axon
namespace: cellular_component
def: "Extremely large, unmyelinated axon found in invertebrates. Has high conduction speeds and is usually involved in panic or escape responses." [GOC:jl, PMID:9705477]
is_a: GO:0030424 ! axon

[Term]
id: GO:0042758
name: long-chain fatty acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of long-chain fatty acids, a fatty acid with a chain length between C13 and C22." [CHEBI:15904, GOC:go_curators]
subset: gosubset_prok
synonym: "long-chain fatty acid breakdown" EXACT []
synonym: "long-chain fatty acid catabolism" EXACT []
synonym: "long-chain fatty acid degradation" EXACT []
is_a: GO:0001676 ! long-chain fatty acid metabolic process
is_a: GO:0009062 ! fatty acid catabolic process

[Term]
id: GO:0042759
name: long-chain fatty acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of long-chain fatty acids, any fatty acid with a chain length between C13 and C22." [CHEBI:15904, GOC:go_curators]
subset: gosubset_prok
synonym: "long-chain fatty acid anabolism" EXACT []
synonym: "long-chain fatty acid biosynthesis" EXACT []
synonym: "long-chain fatty acid formation" EXACT []
synonym: "long-chain fatty acid synthesis" EXACT []
is_a: GO:0001676 ! long-chain fatty acid metabolic process
is_a: GO:0006633 ! fatty acid biosynthetic process

[Term]
id: GO:0042760
name: very long-chain fatty acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a fatty acid which has a chain length greater than C22." [CHEBI:27283, GOC:go_curators]
subset: gosubset_prok
synonym: "very-long-chain fatty acid breakdown" EXACT []
synonym: "very-long-chain fatty acid catabolic process" EXACT []
synonym: "very-long-chain fatty acid catabolism" EXACT []
synonym: "very-long-chain fatty acid degradation" EXACT []
is_a: GO:0000038 ! very long-chain fatty acid metabolic process
is_a: GO:0009062 ! fatty acid catabolic process

[Term]
id: GO:0042761
name: very long-chain fatty acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a fatty acid which has a chain length greater than C22." [CHEBI:27283, GOC:go_curators]
subset: gosubset_prok
synonym: "very-long-chain fatty acid anabolism" EXACT []
synonym: "very-long-chain fatty acid biosynthesis" EXACT []
synonym: "very-long-chain fatty acid biosynthetic process" EXACT []
synonym: "very-long-chain fatty acid formation" EXACT []
synonym: "very-long-chain fatty acid synthesis" EXACT []
xref: MetaCyc:PWY-5080
is_a: GO:0000038 ! very long-chain fatty acid metabolic process
is_a: GO:0006633 ! fatty acid biosynthetic process

[Term]
id: GO:0042762
name: regulation of sulfur metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur, the nonmetallic element sulfur or compounds that contain sulfur." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of sulfur metabolism" EXACT []
synonym: "regulation of sulphur metabolic process" EXACT []
synonym: "regulation of sulphur metabolism" EXACT []
is_a: GO:0031323 ! regulation of cellular metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006790 ! sulfur compound metabolic process
relationship: regulates GO:0006790 ! sulfur compound metabolic process

[Term]
id: GO:0042763
name: intracellular immature spore
namespace: cellular_component
def: "A cell or part of the cell that constitutes an early developmental stage of a spore, a small reproductive body that is highly resistant to desiccation and heat and is capable of growing into a new organism, produced especially by certain bacteria, fungi, algae, and nonflowering plants." [GOC:jl, ISBN:0395825172]
subset: gosubset_prok
synonym: "forespore" RELATED []
is_a: GO:0044464 ! cell part

[Term]
id: GO:0042764
name: ascospore-type prospore
namespace: cellular_component
def: "An immature spore undergoing development. The spore usually consists of nucleic acid, prospore membrane(s) that encase the nucleic acid, and ultimately a cell wall that covers the membrane(s). This type of spore is observed in ascospore-forming fungi." [GOC:go_curators]
is_a: GO:0042763 ! intracellular immature spore

[Term]
id: GO:0042765
name: GPI-anchor transamidase complex
namespace: cellular_component
def: "An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxyl-terminus of a precursor protein to a GPI-anchor." [GOC:jl, GOC:rb, PMID:12802054]
comment: Note that this term should not be confused with 'glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex ; GO:0000506', which represents a distinct complex with a different catalytic activity.
synonym: "GPIT complex" EXACT []
is_a: GO:0044432 ! endoplasmic reticulum part
is_a: GO:0098796 ! membrane protein complex
is_a: GO:1902494 ! catalytic complex
relationship: part_of GO:0030176 ! integral component of endoplasmic reticulum membrane

[Term]
id: GO:0042766
name: nucleosome mobilization
namespace: biological_process
def: "The movement of nucleosomes along a DNA fragment." [PMID:12006495]
synonym: "nucleosome sliding" EXACT [GOC:dph]
is_a: GO:0006338 ! chromatin remodeling
is_a: GO:0034728 ! nucleosome organization

[Term]
id: GO:0042767
name: ecdysteroid 22-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the hydroxylation of an ecdysteroid at carbon position 22." [PMID:12177427]
comment: Note that in the ecdysteroidogenic pathway, this activity catalyzes the conversion of 2,22-dideoxyecdysone (ketotriol) to 2-deoxyecdysone.
is_a: GO:0008395 ! steroid hydroxylase activity

[Term]
id: GO:0042768
name: ecdysteroid 2-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the hydroxylation of an ecdysteroid at carbon position 2." [PMID:12177427]
comment: Note that in the ecdysteroidogenic pathway, this activity catalyzes the conversion of 2-deoxyecdysone to ecdysone. It can also catalyze the conversion of 2,22-dideoxyecdysone (ketotriol) to 22-deoxyecdysone.
is_a: GO:0008395 ! steroid hydroxylase activity

[Term]
id: GO:0042769
name: DNA damage response, detection of DNA damage
namespace: biological_process
def: "The series of events required to receive a stimulus indicating DNA damage has occurred and convert it to a molecular signal." [GOC:go_curators]
synonym: "detection of DNA damage during DNA damage response" EXACT []
synonym: "DNA damage response, perception of DNA damage" RELATED []
is_a: GO:0006974 ! cellular response to DNA damage stimulus
is_a: GO:0051606 ! detection of stimulus

[Term]
id: GO:0042770
name: signal transduction in response to DNA damage
namespace: biological_process
def: "A cascade of processes induced by the detection of DNA damage within a cell." [GOC:go_curators]
synonym: "DNA damage response, signal transduction" EXACT [GOC:curators]
synonym: "response to DNA damage stimulus by intracellular signaling cascade" EXACT [GOC:dph, GOC:tb]
is_a: GO:0006974 ! cellular response to DNA damage stimulus
is_a: GO:0035556 ! intracellular signal transduction

[Term]
id: GO:0042771
name: intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
namespace: biological_process
def: "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered." [GOC:go_curators, GOC:mtg_apoptosis]
synonym: "DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED []
is_a: GO:0008630 ! intrinsic apoptotic signaling pathway in response to DNA damage
is_a: GO:0072332 ! intrinsic apoptotic signaling pathway by p53 class mediator

[Term]
id: GO:0042772
name: DNA damage response, signal transduction resulting in transcription
namespace: biological_process
def: "A cascade of processes initiated in response to the detection of DNA damage, and resulting in the induction of transcription." [GOC:go_curators]
is_a: GO:0042770 ! signal transduction in response to DNA damage

[Term]
id: GO:0042773
name: ATP synthesis coupled electron transport
namespace: biological_process
def: "The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP." [ISBN:0716731363]
subset: gosubset_prok
is_a: GO:0022904 ! respiratory electron transport chain
relationship: part_of GO:0006119 ! oxidative phosphorylation

[Term]
id: GO:0042774
name: plasma membrane ATP synthesis coupled electron transport
namespace: biological_process
def: "The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP in the plasma membrane." [GOC:mtg_sensu, ISBN:0716731363]
subset: gosubset_prok
is_a: GO:0042773 ! ATP synthesis coupled electron transport
intersection_of: GO:0042773 ! ATP synthesis coupled electron transport
intersection_of: occurs_in GO:0005886 ! plasma membrane
relationship: occurs_in GO:0005886 ! plasma membrane

[Term]
id: GO:0042775
name: mitochondrial ATP synthesis coupled electron transport
namespace: biological_process
def: "The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane or chloroplast thylakoid membrane." [GOC:mtg_sensu, ISBN:0716731363]
synonym: "mitochondrial electron transport" BROAD []
synonym: "organelle ATP synthesis coupled electron transport" BROAD []
is_a: GO:0042773 ! ATP synthesis coupled electron transport
intersection_of: GO:0042773 ! ATP synthesis coupled electron transport
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion

[Term]
id: GO:0042776
name: mitochondrial ATP synthesis coupled proton transport
namespace: biological_process
def: "The transport of protons across a mitochondrial membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [GOC:mtg_sensu, ISBN:0716731363]
synonym: "mitochondrial proton transport" BROAD []
xref: Reactome:REACT_100086 "Formation of ATP by chemiosmotic coupling, Rattus norvegicus"
xref: Reactome:REACT_104111 "Formation of ATP by chemiosmotic coupling, Canis familiaris"
xref: Reactome:REACT_1985 "Enzyme-bound ATP is released, Homo sapiens"
xref: Reactome:REACT_29417 "Enzyme-bound ATP is released, Bos taurus"
xref: Reactome:REACT_30958 "Formation of ATP by chemiosmotic coupling, Bos taurus"
xref: Reactome:REACT_6759 "Formation of ATP by chemiosmotic coupling, Homo sapiens"
xref: Reactome:REACT_77222 "Enzyme-bound ATP is released, Canis familiaris"
xref: Reactome:REACT_79130 "Enzyme-bound ATP is released, Mus musculus"
xref: Reactome:REACT_81880 "Formation of ATP by chemiosmotic coupling, Danio rerio"
xref: Reactome:REACT_82120 "Enzyme-bound ATP is released, Gallus gallus"
xref: Reactome:REACT_85356 "Formation of ATP by chemiosmotic coupling, Mus musculus"
xref: Reactome:REACT_88718 "Enzyme-bound ATP is released, Rattus norvegicus"
xref: Reactome:REACT_93236 "Enzyme-bound ATP is released, Danio rerio"
xref: Reactome:REACT_93401 "Formation of ATP by chemiosmotic coupling, Sus scrofa"
xref: Reactome:REACT_97205 "Formation of ATP by chemiosmotic coupling, Gallus gallus"
xref: Reactome:REACT_97485 "Enzyme-bound ATP is released, Sus scrofa"
is_a: GO:0015986 ! ATP synthesis coupled proton transport
is_a: GO:1990542 ! mitochondrial transmembrane transport
intersection_of: GO:0015986 ! ATP synthesis coupled proton transport
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion

[Term]
id: GO:0042777
name: plasma membrane ATP synthesis coupled proton transport
namespace: biological_process
def: "The transport of protons across the plasma membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [GOC:mtg_sensu, ISBN:0716731363]
subset: gosubset_prok
synonym: "ATP synthesis coupled proton transport" BROAD []
is_a: GO:0015986 ! ATP synthesis coupled proton transport

[Term]
id: GO:0042778
name: tRNA end turnover
namespace: biological_process
def: "The process in which the 3'-terminal CCA of a tRNA is removed and restored. This often happens to uncharged tRNA." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0006399 ! tRNA metabolic process

[Term]
id: GO:0042779
name: tRNA 3'-trailer cleavage
namespace: biological_process
def: "Cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA; may involve endonucleolytic or exonucleolytic cleavage, or both." [GOC:go_curators]
subset: gosubset_prok
synonym: "removal of tRNA 3'-trailer sequence" EXACT []
synonym: "tRNA 3'-end cleavage" EXACT []
is_a: GO:0042780 ! tRNA 3'-end processing
is_a: GO:0090501 ! RNA phosphodiester bond hydrolysis

[Term]
id: GO:0042780
name: tRNA 3'-end processing
namespace: biological_process
def: "The process in which the 3' end of a pre-tRNA molecule is converted to that of a mature tRNA." [GOC:go_curators]
subset: gosubset_prok
synonym: "tRNA 3' processing" EXACT []
is_a: GO:0008033 ! tRNA processing
is_a: GO:0043628 ! ncRNA 3'-end processing

[Term]
id: GO:0042781
name: 3'-tRNA processing endoribonuclease activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule." [EC:3.1.26.11]
subset: gosubset_prok
synonym: "3 tRNase activity" EXACT [EC:3.1.26.11]
synonym: "3' tRNA processing endoribonuclease activity" EXACT []
synonym: "3' tRNase activity" EXACT []
synonym: "ribonuclease Z activity" BROAD []
synonym: "RNase Z activity" BROAD []
synonym: "tRNA 3 endonuclease activity" EXACT [EC:3.1.26.11]
synonym: "tRNA 3' endonuclease activity" EXACT []
synonym: "tRNAse Z" RELATED [EC:3.1.26.11]
xref: MetaCyc:3.1.26.11-RXN
is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters
relationship: part_of GO:0034414 ! tRNA 3'-trailer cleavage, endonucleolytic

[Term]
id: GO:0042782
name: passive evasion of host immune response
namespace: biological_process
def: "Any mechanism of immune avoidance that does not directly interfere with the host immune system; for example, some viruses enter a state of latency where their protein production is drastically downregulated, meaning that they are not detected by the host immune system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:12439615]
subset: gosubset_prok
synonym: "passive immune evasion" BROAD []
is_a: GO:0020012 ! evasion or tolerance of host immune response
is_a: GO:0051809 ! passive evasion of immune response of other organism involved in symbiotic interaction

[Term]
id: GO:0042783
name: active evasion of host immune response
namespace: biological_process
def: "Any mechanism of immune avoidance that directly affects the host immune system, e.g. blocking any stage in host MHC class I and II presentation. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:12439615]
subset: gosubset_prok
synonym: "active immune evasion" BROAD []
is_a: GO:0020012 ! evasion or tolerance of host immune response
is_a: GO:0051810 ! active evasion of immune response of other organism involved in symbiotic interaction

[Term]
id: GO:0042784
name: active evasion of host immune response via regulation of host complement system
namespace: biological_process
def: "Any mechanism of active immune avoidance which works by regulating the host complement system, e.g. by possessing complement receptors which mediate attachment to, then infection of, host macrophages, which are eventually destroyed. The host is defined as the larger of the organisms involved in a symbiotic interaction." [http://www.brown.edu/Courses/Bio_160/Projects1999/ies/ces.html]
synonym: "active immune evasion via modulation of host complement system" EXACT []
synonym: "active immune evasion via regulation of host complement system" EXACT []
is_a: GO:0042783 ! active evasion of host immune response
is_a: GO:0051811 ! active evasion of immune response of other organism via regulation of complement system of other organism involved in symbiotic interaction

[Term]
id: GO:0042785
name: active evasion of host immune response via regulation of host cytokine network
namespace: biological_process
def: "Any mechanism of active immune avoidance which works by regulating host cytokine networks, e.g. by secreting proteins that mimic cytokine receptors that act to sequester host cytokines and inhibit action. The host is defined as the larger of the organisms involved in a symbiotic interaction." [http://www.brown.edu/Courses/Bio_160/Projects1999/ies/cytok.html#Manipulation]
synonym: "active immune evasion via modulation of host cytokine network" EXACT []
synonym: "active immune evasion via regulation of host cytokine network" EXACT []
is_a: GO:0042783 ! active evasion of host immune response
is_a: GO:0051812 ! active evasion of immune response of other organism via regulation of cytokine network of other organism involved in symbiotic interaction

[Term]
id: GO:0042786
name: active evasion of host immune response via regulation of host antigen processing and presentation
namespace: biological_process
def: "Any mechanism of active immune avoidance which works by regulating the host's antigen processing or presentation pathways, e.g. by blocking any stage in MHC class II presentation. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:12439615]
synonym: "active evasion of host immune response via regulation of host antigen processing and presentation pathway" EXACT []
synonym: "active immune evasion via modulation of antigen processing and presentation" EXACT []
synonym: "active immune evasion via modulation of antigen processing/presentation" EXACT []
synonym: "active immune evasion via regulation of antigen processing and presentation" EXACT []
is_a: GO:0042783 ! active evasion of host immune response

[Term]
id: GO:0042787
name: protein ubiquitination involved in ubiquitin-dependent protein catabolic process
namespace: biological_process
alt_id: GO:0043432
def: "The process in which a ubiquitin group, or multiple groups, are covalently attached to the target protein, thereby initiating the degradation of that protein." [GOC:go_curators]
synonym: "myofibrillar protein ubiquitination during ubiquitin-dependent protein breakdown" NARROW []
synonym: "myofibrillar protein ubiquitination during ubiquitin-dependent protein catabolic process" NARROW []
synonym: "myofibrillar protein ubiquitination during ubiquitin-dependent protein catabolism" NARROW []
synonym: "myofibrillar protein ubiquitination during ubiquitin-dependent protein degradation" NARROW []
synonym: "protein degradation tagging activity" RELATED []
synonym: "protein ubiquitination during ubiquitin-dependent protein breakdown" EXACT []
synonym: "protein ubiquitination during ubiquitin-dependent protein catabolic process" RELATED [GOC:dph, GOC:tb]
synonym: "protein ubiquitination during ubiquitin-dependent protein catabolism" EXACT []
synonym: "protein ubiquitination during ubiquitin-dependent protein degradation" EXACT []
synonym: "protein ubiquitinylation during ubiquitin-dependent protein catabolic process" EXACT []
synonym: "protein ubiquitinylation during ubiquitin-dependent protein catabolism" EXACT []
synonym: "protein ubiquitylation during ubiquitin-dependent protein catabolic process" EXACT []
synonym: "protein ubiquitylation during ubiquitin-dependent protein catabolism" EXACT []
xref: Reactome:REACT_100004 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex, Canis familiaris"
xref: Reactome:REACT_100823 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex, Mus musculus"
xref: Reactome:REACT_101110 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex, Mus musculus"
xref: Reactome:REACT_103809 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex, Xenopus tropicalis"
xref: Reactome:REACT_104518 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex, Taeniopygia guttata"
xref: Reactome:REACT_105370 "Multiubiquitination of APC/C-associated Cdh1, Danio rerio"
xref: Reactome:REACT_105620 "Multiubiquitination of APC/C-associated Cdh1, Taeniopygia guttata"
xref: Reactome:REACT_106156 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex, Rattus norvegicus"
xref: Reactome:REACT_106906 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex, Xenopus tropicalis"
xref: Reactome:REACT_107379 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex, Xenopus tropicalis"
xref: Reactome:REACT_107829 "Multiubiquitination of APC/C-associated Cdh1, Rattus norvegicus"
xref: Reactome:REACT_108446 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex, Danio rerio"
xref: Reactome:REACT_108589 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex, Mus musculus"
xref: Reactome:REACT_109071 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex, Drosophila melanogaster"
xref: Reactome:REACT_110158 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex, Gallus gallus"
xref: Reactome:REACT_114376 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex, Oryza sativa"
xref: Reactome:REACT_28669 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex, Drosophila melanogaster"
xref: Reactome:REACT_30747 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex, Bos taurus"
xref: Reactome:REACT_31985 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex, Danio rerio"
xref: Reactome:REACT_32728 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex, Gallus gallus"
xref: Reactome:REACT_32748 "Multiubiquitination of APC/C-associated Cdh1, Mus musculus"
xref: Reactome:REACT_33468 "Multiubiquitination of APC/C-associated Cdh1, Bos taurus"
xref: Reactome:REACT_6723 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex, Homo sapiens"
xref: Reactome:REACT_6735 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex, Homo sapiens"
xref: Reactome:REACT_6791 "Multiubiquitination of APC/C-associated Cdh1, Homo sapiens"
xref: Reactome:REACT_6824 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex, Homo sapiens"
xref: Reactome:REACT_6914 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex, Homo sapiens"
xref: Reactome:REACT_77058 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex, Bos taurus"
xref: Reactome:REACT_78216 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex, Rattus norvegicus"
xref: Reactome:REACT_78475 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex, Taeniopygia guttata"
xref: Reactome:REACT_79393 "Multiubiquitination of APC/C-associated Cdh1, Drosophila melanogaster"
xref: Reactome:REACT_79773 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex, Xenopus tropicalis"
xref: Reactome:REACT_79781 "Multiubiquitination of APC/C-associated Cdh1, Oryza sativa"
xref: Reactome:REACT_80157 "Multiubiquitination of APC/C-associated Cdh1, Xenopus tropicalis"
xref: Reactome:REACT_80243 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex, Taeniopygia guttata"
xref: Reactome:REACT_81796 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex, Canis familiaris"
xref: Reactome:REACT_81809 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex, Gallus gallus"
xref: Reactome:REACT_85194 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex, Drosophila melanogaster"
xref: Reactome:REACT_86043 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex, Danio rerio"
xref: Reactome:REACT_87217 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex, Gallus gallus"
xref: Reactome:REACT_87349 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex, Taeniopygia guttata"
xref: Reactome:REACT_89066 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex, Mus musculus"
xref: Reactome:REACT_91216 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex, Oryza sativa"
xref: Reactome:REACT_91336 "Multiubiquitination of APC/C-associated Cdh1, Gallus gallus"
xref: Reactome:REACT_91686 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex, Bos taurus"
xref: Reactome:REACT_91885 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex, Rattus norvegicus"
xref: Reactome:REACT_92341 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex, Dictyostelium discoideum"
xref: Reactome:REACT_92878 "Multiubiquitination of APC/C-associated Cdh1, Canis familiaris"
xref: Reactome:REACT_94687 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex, Bos taurus"
xref: Reactome:REACT_94864 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex, Canis familiaris"
xref: Reactome:REACT_95501 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex, Canis familiaris"
xref: Reactome:REACT_97971 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex, Drosophila melanogaster"
xref: Reactome:REACT_98894 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex, Rattus norvegicus"
xref: Reactome:REACT_99825 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex, Danio rerio"
is_a: GO:0016567 ! protein ubiquitination
intersection_of: GO:0016567 ! protein ubiquitination
intersection_of: part_of GO:0006511 ! ubiquitin-dependent protein catabolic process
relationship: part_of GO:0006511 ! ubiquitin-dependent protein catabolic process

[Term]
id: GO:0042788
name: polysomal ribosome
namespace: cellular_component
def: "A ribosome bound to mRNA that forms part of a polysome." [GOC:jl]
synonym: "active ribosome" BROAD []
is_a: GO:0005840 ! ribosome
intersection_of: GO:0005840 ! ribosome
intersection_of: part_of GO:0005844 ! polysome
relationship: part_of GO:0005844 ! polysome

[Term]
id: GO:0042789
name: mRNA transcription from RNA polymerase II promoter
namespace: biological_process
def: "The cellular synthesis of messenger RNA (mRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter." [GOC:jl, ISBN:0321000382]
synonym: "mRNA transcription from Pol II promoter" EXACT []
is_a: GO:0006366 ! transcription from RNA polymerase II promoter
is_a: GO:0009299 ! mRNA transcription

[Term]
id: GO:0042790
name: transcription of nuclear large rRNA transcript from RNA polymerase I promoter
namespace: biological_process
def: "The synthesis of the large ribosomal RNA (rRNA) transcript which encodes several rRNAs, e.g. in mammals 28S, 18S and 5.8S, from a nuclear DNA template transcribed by RNA polymerase I." [GOC:jl, GOC:txnOH, ISBN:0321000382]
synonym: "transcription of nuclear rRNA large Pol I transcript" EXACT []
is_a: GO:0006360 ! transcription from RNA polymerase I promoter
is_a: GO:0009303 ! rRNA transcription

[Term]
id: GO:0042791
name: 5S class rRNA transcription from RNA polymerase III type 1 promoter
namespace: biological_process
def: "The synthesis of 5S ribosomal RNA (rRNA), or an equivalent rRNA, from a DNA template by RNA polymerase III (Pol III), originating at a type 1 RNA polymerase III promoter." [GOC:jl, GOC:txnOH, ISBN:0321000382, PMID:12381659]
subset: gosubset_prok
synonym: "5S rRNA transcription" EXACT []
is_a: GO:0006383 ! transcription from RNA polymerase III promoter
is_a: GO:0009303 ! rRNA transcription

[Term]
id: GO:0042792
name: rRNA transcription from mitochondrial promoter
namespace: biological_process
def: "The synthesis of ribosomal RNA (rRNA) from a mitochondrial DNA template." [GOC:jl, ISBN:0321000382]
is_a: GO:0006390 ! transcription from mitochondrial promoter
is_a: GO:0009303 ! rRNA transcription

[Term]
id: GO:0042793
name: transcription from plastid promoter
namespace: biological_process
def: "The synthesis of RNA from a plastid DNA template, usually by a specific plastid RNA polymerase." [GOC:jl, ISBN:0321000382]
synonym: "plastid transcription" EXACT []
is_a: GO:0006351 ! transcription, DNA-templated
is_a: GO:0009657 ! plastid organization
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:1902589 ! single-organism organelle organization

[Term]
id: GO:0042794
name: rRNA transcription from plastid promoter
namespace: biological_process
def: "The synthesis of ribosomal RNA (rRNA) from a plastid DNA template, usually by a specific plastid RNA polymerase." [GOC:jl, ISBN:0321000382]
is_a: GO:0009303 ! rRNA transcription
is_a: GO:0042793 ! transcription from plastid promoter

[Term]
id: GO:0042795
name: snRNA transcription from RNA polymerase II promoter
namespace: biological_process
def: "The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase II (Pol II), originating at a Pol II promoter." [GOC:jl, ISBN:0321000382]
synonym: "snRNA transcription from Pol II promoter" EXACT []
is_a: GO:0006366 ! transcription from RNA polymerase II promoter
is_a: GO:0009301 ! snRNA transcription

[Term]
id: GO:0042796
name: snRNA transcription from RNA polymerase III promoter
namespace: biological_process
def: "The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase III (Pol III), originating at a Pol III promoter." [GOC:jl, ISBN:0321000382]
synonym: "snRNA transcription from Pol III promoter" EXACT []
is_a: GO:0006383 ! transcription from RNA polymerase III promoter
is_a: GO:0009301 ! snRNA transcription

[Term]
id: GO:0042797
name: tRNA transcription from RNA polymerase III promoter
namespace: biological_process
def: "The synthesis of transfer RNA (tRNA) from a DNA template by RNA Polymerase III (Pol III), originating at a Pol III promoter." [GOC:jl, ISBN:0321000382]
synonym: "tRNA transcription from Pol III promoter" EXACT []
is_a: GO:0006383 ! transcription from RNA polymerase III promoter
is_a: GO:0009304 ! tRNA transcription

[Term]
id: GO:0042798
name: obsolete protein neddylation during NEDD8 class-dependent protein catabolic process
namespace: biological_process
def: "OBSOLETE. Covalent attachment of the ubiquitin-like protein NEDD8 (or equivalent protein) to another protein, as a part of NEDD8-dependant protein catabolism." [GOC:jl]
comment: This term was made obsolete because NEDD8-class tags do not target proteins for proteolytic destruction.
synonym: "protein neddylation during NEDD8 class-dependent protein breakdown" EXACT []
synonym: "protein neddylation during NEDD8 class-dependent protein catabolic process" EXACT []
synonym: "protein neddylation during NEDD8 class-dependent protein catabolism" EXACT []
synonym: "protein neddylation during NEDD8 class-dependent protein degradation" EXACT []
synonym: "protein neddylation during RUB1-dependent protein catabolic process" EXACT []
synonym: "protein neddylation during RUB1-dependent protein catabolism" EXACT []
is_obsolete: true
consider: GO:0045116

[Term]
id: GO:0042799
name: histone methyltransferase activity (H4-K20 specific)
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone H4 L-lysine (position 20) = S-adenosyl-L-homocysteine + histone H4 N6-methyl-L-lysine (position 20). This reaction is the addition of a methyl group onto lysine at position 20 of the histone H4 protein." [PMID:12086618]
comment: Note that in some species, the methyl group may be added to a lysine in a slightly different position of the histone H4 protein, but that this term still applies.
synonym: "histone H4 lysine 20-specific methyltransferase activity" EXACT []
synonym: "histone lysine N-methyltransferase activity (H4-K20 specific)" EXACT []
synonym: "histone methylase activity (H4-K20 specific)" EXACT [GOC:mah]
is_a: GO:0018024 ! histone-lysine N-methyltransferase activity
relationship: part_of GO:0034770 ! histone H4-K20 methylation

[Term]
id: GO:0042800
name: histone methyltransferase activity (H3-K4 specific)
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of a methyl group onto lysine at position 4 of the histone H3 protein." [PMID:12086618]
comment: Note that in some species, the methyl group may be added to a lysine in a slightly different position of the histone H3 protein, but that this term still applies.
synonym: "histone H3 lysine 4-specific methyltransferase activity" EXACT []
synonym: "histone lysine N-methyltransferase activity (H3-K4 specific)" EXACT []
synonym: "histone methylase activity (H3-K4 specific)" EXACT [GOC:mah]
xref: Reactome:REACT_27174 "Prdm9 Trimethylates Histone H3 (murine, bovine), Bos taurus"
xref: Reactome:REACT_27242 "Trimethylation of Histone H3 by PRDM9, Homo sapiens"
xref: Reactome:REACT_27263 "Prdm9 Trimethylates Histone H3 at Lysine-4, Mus musculus"
is_a: GO:0018024 ! histone-lysine N-methyltransferase activity
relationship: part_of GO:0051568 ! histone H3-K4 methylation

[Term]
id: GO:0042801
name: polo kinase kinase activity
namespace: molecular_function
def: "Catalysis of the addition of a phosphate group onto a serine or threonine residue in any member of the polo kinase class of proteins." [GOC:ma]
is_a: GO:0004702 ! receptor signaling protein serine/threonine kinase activity

[Term]
id: GO:0042802
name: identical protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an identical protein or proteins." [GOC:jl]
subset: goslim_chembl
subset: gosubset_prok
synonym: "isoform-specific homophilic binding" EXACT [PMID:17889655]
synonym: "protein homopolymerization" RELATED []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0042803
name: protein homodimerization activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
subset: goslim_chembl
subset: gosubset_prok
synonym: "dimerization activity" BROAD []
is_a: GO:0042802 ! identical protein binding
is_a: GO:0046983 ! protein dimerization activity

[Term]
id: GO:0042804
name: obsolete protein homooligomerization activity
namespace: molecular_function
def: "OBSOLETE. Interacting selectively with identical proteins to form a homooligomer." [GOC:jl]
comment: This term was made obsolete because it represents a biological process.
synonym: "oligomerization activity" BROAD []
synonym: "protein homooligomerization activity" EXACT []
is_obsolete: true
replaced_by: GO:0051260

[Term]
id: GO:0042805
name: actinin binding
namespace: molecular_function
alt_id: GO:0051406
def: "Interacting selectively and non-covalently with actinin, any member of a family of proteins that crosslink F-actin." [GOC:jl, ISBN:0198506732]
synonym: "beta-actinin binding" NARROW []
synonym: "capZ binding" EXACT []
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0042806
name: fucose binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with fucose, the pentose 6-deoxygalactose." [CHEBI:33984, ISBN:0582227089]
is_a: GO:0048029 ! monosaccharide binding

[Term]
id: GO:0042807
name: central vacuole
namespace: cellular_component
def: "A membrane-enclosed sac that takes up most of the volume of a mature plant cell. Functions include storage, separation of toxic byproducts, and cell growth determination." [ISBN:9780815341116, Wikipedia:Vacuole]
is_a: GO:0000325 ! plant-type vacuole

[Term]
id: GO:0042808
name: obsolete neuronal Cdc2-like kinase binding
namespace: molecular_function
def: "OBSOLETE. Interacting selectively and non-covalently with neuronal Cdc2-like kinase, an enzyme involved in the regulation of neuronal differentiation and neuro-cytoskeleton dynamics." [GOC:jl, PMID:10721722]
comment: This term was made obsolete because it represents binding to an individual protein.
synonym: "neuronal Cdc2-like kinase binding" EXACT []
is_obsolete: true
replaced_by: GO:0019901

[Term]
id: GO:0042809
name: vitamin D receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the vitamin D receptor, a nuclear receptor that mediates the action of vitamin D by binding DNA and controlling the transcription of hormone-sensitive genes." [GOC:jl, PMID:12637589]
synonym: "calciferol receptor binding" NARROW []
synonym: "VDR binding" EXACT []
is_a: GO:0008134 ! transcription factor binding
is_a: GO:0035257 ! nuclear hormone receptor binding

[Term]
id: GO:0042810
name: pheromone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
synonym: "pheromone metabolism" EXACT []
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0042445 ! hormone metabolic process
is_a: GO:0044237 ! cellular metabolic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0042811
name: pheromone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [ISBN:0198506732]
subset: gosubset_prok
synonym: "pheromone anabolism" EXACT []
synonym: "pheromone biosynthesis" EXACT []
synonym: "pheromone formation" EXACT []
synonym: "pheromone synthesis" EXACT []
is_a: GO:0042446 ! hormone biosynthetic process
is_a: GO:0042810 ! pheromone metabolic process
is_a: GO:0044249 ! cellular biosynthetic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process

[Term]
id: GO:0042812
name: pheromone catabolic process
namespace: biological_process
alt_id: GO:0007327
alt_id: GO:0046614
def: "The chemical reactions and pathways resulting in the breakdown of pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [ISBN:0198506732]
subset: gosubset_prok
synonym: "pheromone breakdown" EXACT []
synonym: "pheromone catabolism" EXACT []
synonym: "pheromone degradation" EXACT []
is_a: GO:0042447 ! hormone catabolic process
is_a: GO:0042810 ! pheromone metabolic process
is_a: GO:0044248 ! cellular catabolic process
is_a: GO:0044712 ! single-organism catabolic process

[Term]
id: GO:0042813
name: Wnt-activated receptor activity
namespace: molecular_function
def: "Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:go_curators]
subset: goslim_chembl
synonym: "frizzled receptor activity" RELATED []
synonym: "frizzled-2 receptor activity" RELATED []
synonym: "Wnt receptor activity" EXACT [GOC:bf, GOC:signaling]
is_a: GO:0004888 ! transmembrane signaling receptor activity
relationship: has_part GO:0017147 ! Wnt-protein binding
relationship: part_of GO:0016055 ! Wnt signaling pathway

[Term]
id: GO:0042814
name: monopolar cell growth
namespace: biological_process
def: "Polarized growth from one end of a cell." [GOC:vw]
synonym: "monopolar cell elongation" NARROW []
synonym: "monopolar growth" BROAD []
synonym: "polar cell elongation" NARROW []
is_a: GO:0009826 ! unidimensional cell growth

[Term]
id: GO:0042815
name: bipolar cell growth
namespace: biological_process
def: "The process in which a cell irreversibly increases in size along one axis through simultaneous polarized growth from opposite ends of a cell, resulting in morphogenesis of the cell." [GOC:vw]
comment: Bipolar cell growth refers to a change in both cell size and cell shape. For shape changes where cell size is not affected, consider instead the term 'establishment or maintenance of bipolar cell polarity resulting in cell shape ; GO:0061246' and its children.
synonym: "bipolar cell elongation" NARROW []
synonym: "bipolar growth" BROAD []
synonym: "polar cell elongation" RELATED []
is_a: GO:0009826 ! unidimensional cell growth

[Term]
id: GO:0042816
name: vitamin B6 metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any of the vitamin B6 compounds: pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html]
subset: gosubset_prok
synonym: "vitamin B6 metabolism" EXACT []
xref: Reactome:REACT_25012 "Vitamins B6 activation to pyridoxal phosphate, Homo sapiens"
is_a: GO:0006767 ! water-soluble vitamin metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0072524 ! pyridine-containing compound metabolic process

[Term]
id: GO:0042817
name: pyridoxal metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:jl, http://www.mblab.gla.ac.uk/]
subset: gosubset_prok
synonym: "pyridoxal metabolism" EXACT []
is_a: GO:0006081 ! cellular aldehyde metabolic process
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0042816 ! vitamin B6 metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process

[Term]
id: GO:0042818
name: pyridoxamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [CHEBI:16410, GOC:jl]
subset: gosubset_prok
synonym: "pyridoxamine metabolism" EXACT []
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0042816 ! vitamin B6 metabolic process
is_a: GO:0097164 ! ammonium ion metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process

[Term]
id: GO:0042819
name: vitamin B6 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any of the vitamin B6 compounds; pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html]
subset: gosubset_prok
synonym: "pyridoxine-5'-phosphate biosynthesis" RELATED [GOC:yaf, UniPathway:UPA00244]
synonym: "vitamin B6 anabolism" EXACT []
synonym: "vitamin B6 biosynthesis" EXACT []
synonym: "vitamin B6 formation" EXACT []
synonym: "vitamin B6 synthesis" EXACT []
is_a: GO:0042364 ! water-soluble vitamin biosynthetic process
is_a: GO:0042816 ! vitamin B6 metabolic process
is_a: GO:0072525 ! pyridine-containing compound biosynthetic process

[Term]
id: GO:0042820
name: vitamin B6 catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any of the vitamin B6 compounds; pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html]
subset: gosubset_prok
synonym: "vitamin B6 breakdown" EXACT []
synonym: "vitamin B6 catabolism" EXACT []
synonym: "vitamin B6 degradation" EXACT []
is_a: GO:0042365 ! water-soluble vitamin catabolic process
is_a: GO:0042816 ! vitamin B6 metabolic process
is_a: GO:0072526 ! pyridine-containing compound catabolic process

[Term]
id: GO:0042821
name: pyridoxal biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, one of the vitamin B6 compounds." [GOC:jl, http://www.mblab.gla.ac.uk/]
subset: gosubset_prok
synonym: "pyridoxal anabolism" EXACT []
synonym: "pyridoxal biosynthesis" EXACT []
synonym: "pyridoxal formation" EXACT []
synonym: "pyridoxal synthesis" EXACT []
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0042817 ! pyridoxal metabolic process
is_a: GO:0042819 ! vitamin B6 biosynthetic process
is_a: GO:0046184 ! aldehyde biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process

[Term]
id: GO:0042822
name: pyridoxal phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6." [GOC:jl, http://www.mercksource.com/]
subset: gosubset_prok
synonym: "active vitamin B6 metabolic process" EXACT []
synonym: "active vitamin B6 metabolism" EXACT []
synonym: "pyridoxal phosphate metabolism" EXACT []
is_a: GO:0006081 ! cellular aldehyde metabolic process
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:0051186 ! cofactor metabolic process
is_a: GO:0072524 ! pyridine-containing compound metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process

[Term]
id: GO:0042823
name: pyridoxal phosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6." [GOC:jl, http://www.mercksource.com/]
subset: gosubset_prok
synonym: "active vitamin B6 biosynthesis" EXACT []
synonym: "active vitamin B6 biosynthetic process" EXACT []
synonym: "pyridoxal phosphate anabolism" EXACT []
synonym: "pyridoxal phosphate biosynthesis" EXACT []
synonym: "pyridoxal phosphate formation" EXACT []
synonym: "pyridoxal phosphate synthesis" EXACT []
xref: MetaCyc:PWY0-845
is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0042822 ! pyridoxal phosphate metabolic process
is_a: GO:0046184 ! aldehyde biosynthetic process
is_a: GO:0072525 ! pyridine-containing compound biosynthetic process
is_a: GO:0090407 ! organophosphate biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process

[Term]
id: GO:0042824
name: MHC class I peptide loading complex
namespace: cellular_component
def: "A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules." [GOC:jl, PMID:10631934]
comment: Note that although this complex is located in the endoplasmic reticulum, there is some evidence that it may also be found in the Golgi.
subset: goslim_pir
is_a: GO:0044432 ! endoplasmic reticulum part
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0030176 ! integral component of endoplasmic reticulum membrane

[Term]
id: GO:0042825
name: TAP complex
namespace: cellular_component
def: "A heterodimer composed of the subunits TAP1 and TAP2 (transporter associated with antigen presentation). Functions in the transport of antigenic peptides from the cytosol to the lumen of the endoplasmic reticulum." [GOC:jl, PMID:10618487, PMID:10631934]
synonym: "transporter associated with antigen presentation" EXACT []
is_a: GO:0044432 ! endoplasmic reticulum part
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0042824 ! MHC class I peptide loading complex

[Term]
id: GO:0042826
name: histone deacetylase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the enzyme histone deacetylase." [GOC:jl]
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0042827
name: platelet dense granule
namespace: cellular_component
def: "Electron-dense granule occurring in blood platelets that stores and secretes adenosine nucleotides and serotonin. They contain a highly condensed core consisting of serotonin, histamine, calcium, magnesium, ATP, ADP, pyrophosphate and membrane lysosomal proteins." [GOC:jl, http://www.mercksource.com/, PMID:10403682, PMID:11487378]
synonym: "bull's eye body" EXACT []
synonym: "platelet dense body" EXACT []
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0042832
name: defense response to protozoan
namespace: biological_process
def: "Reactions triggered in response to the presence of a protozoan that act to protect the cell or organism." [GOC:jl]
synonym: "defence response to pathogenic protozoa" EXACT []
synonym: "defence response to protozoa" EXACT []
synonym: "defence response to protozoon" EXACT []
synonym: "defense response to pathogenic protozoa" EXACT []
synonym: "defense response to protozoa" EXACT []
synonym: "defense response to protozoon" EXACT []
is_a: GO:0001562 ! response to protozoan
is_a: GO:0098542 ! defense response to other organism

[Term]
id: GO:0042834
name: peptidoglycan binding
namespace: molecular_function
def: "Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls." [GOC:go_curators, PMID:14698226]
subset: gosubset_prok
is_a: GO:0005539 ! glycosaminoglycan binding

[Term]
id: GO:0042835
name: BRE binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the RNA element BRE (Bruno response element)." [PMID:10893231]
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0042836
name: D-glucarate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-glucarate, the D-enantiomer of glucarate. D-glucarate is derived from either D-glucose or L-gulose." [GOC:jsg, GOC:mah, ISBN:0198506732]
subset: gosubset_prok
synonym: "D-glucarate metabolism" EXACT []
synonym: "saccharate metabolic process" EXACT []
synonym: "saccharate metabolism" EXACT []
is_a: GO:0019392 ! glucarate metabolic process

[Term]
id: GO:0042837
name: D-glucarate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of D-glucarate, the D-enantiomer of glucarate." [GOC:jsg, GOC:mah, ISBN:0198506732]
subset: gosubset_prok
synonym: "D-glucarate anabolism" EXACT []
synonym: "D-glucarate biosynthesis" EXACT []
synonym: "D-glucarate formation" EXACT []
synonym: "D-glucarate synthesis" EXACT []
synonym: "saccharate biosynthesis" EXACT []
synonym: "saccharate biosynthetic process" EXACT []
is_a: GO:0019393 ! glucarate biosynthetic process
is_a: GO:0042836 ! D-glucarate metabolic process

[Term]
id: GO:0042838
name: D-glucarate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-glucarate, the D-enantiomer of glucarate." [GOC:jsg, GOC:mah, ISBN:0198506732]
subset: gosubset_prok
synonym: "D-glucarate breakdown" EXACT []
synonym: "D-glucarate catabolism" EXACT []
synonym: "D-glucarate degradation" EXACT []
synonym: "saccharate catabolic process" EXACT []
synonym: "saccharate catabolism" EXACT []
is_a: GO:0019394 ! glucarate catabolic process
is_a: GO:0042836 ! D-glucarate metabolic process

[Term]
id: GO:0042839
name: D-glucuronate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-glucuronate, the D-enantiomer of glucuronate." [GOC:jl, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "D-glucuronate metabolism" EXACT []
is_a: GO:0019585 ! glucuronate metabolic process

[Term]
id: GO:0042840
name: D-glucuronate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-glucuronate, the D-enantiomer of glucuronate." [GOC:jl, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "D-glucuronate breakdown" EXACT []
synonym: "D-glucuronate catabolism" EXACT []
synonym: "D-glucuronate degradation" EXACT []
is_a: GO:0006064 ! glucuronate catabolic process
is_a: GO:0042839 ! D-glucuronate metabolic process

[Term]
id: GO:0042841
name: D-glucuronate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of D-glucuronate, the D-enantiomer of glucuronate." [GOC:jl, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "D-glucuronate anabolism" EXACT []
synonym: "D-glucuronate biosynthesis" EXACT []
synonym: "D-glucuronate formation" EXACT []
synonym: "D-glucuronate synthesis" EXACT []
is_a: GO:0042839 ! D-glucuronate metabolic process
is_a: GO:0046399 ! glucuronate biosynthetic process

[Term]
id: GO:0042842
name: D-xylose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of D-xylose, a naturally occurring plant polysaccharide." [ISBN:0198506732]
subset: gosubset_prok
synonym: "D-xylose anabolism" EXACT []
synonym: "D-xylose biosynthesis" EXACT []
synonym: "D-xylose formation" EXACT []
synonym: "D-xylose synthesis" EXACT []
is_a: GO:0019322 ! pentose biosynthetic process
is_a: GO:0042732 ! D-xylose metabolic process

[Term]
id: GO:0042843
name: D-xylose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-xylose, a naturally occurring plant polysaccharide." [ISBN:0198506732]
subset: gosubset_prok
synonym: "D-xylose breakdown" EXACT []
synonym: "D-xylose catabolism" EXACT []
synonym: "D-xylose degradation" EXACT []
is_a: GO:0019323 ! pentose catabolic process
is_a: GO:0042732 ! D-xylose metabolic process

[Term]
id: GO:0042844
name: glycol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycol, a diol in which the two hydroxy groups are on different carbon atoms, usually but not necessarily adjacent." [CHEBI:13643, http://www.cogsci.princeton.edu/~wn/]
subset: gosubset_prok
synonym: "dihydric alcohol metabolic process" BROAD []
synonym: "dihydric alcohol metabolism" BROAD []
synonym: "glycol metabolism" EXACT []
is_a: GO:0034311 ! diol metabolic process

[Term]
id: GO:0042845
name: glycol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycol, a diol in which the two hydroxy groups are on different carbon atoms, usually but not necessarily adjacent." [CHEBI:13643, http://www.cogsci.princeton.edu/~wn/]
subset: gosubset_prok
synonym: "dihydric alcohol biosynthesis" BROAD []
synonym: "dihydric alcohol biosynthetic process" BROAD []
synonym: "glycol anabolism" EXACT []
synonym: "glycol biosynthesis" EXACT []
synonym: "glycol formation" EXACT []
synonym: "glycol synthesis" EXACT []
is_a: GO:0034312 ! diol biosynthetic process
is_a: GO:0042844 ! glycol metabolic process

[Term]
id: GO:0042846
name: glycol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycol, a diol in which the two hydroxy groups are on different carbon atoms, usually but not necessarily adjacent." [CHEBI:13643, http://www.cogsci.princeton.edu/~wn/]
subset: gosubset_prok
synonym: "dihydric alcohol catabolic process" BROAD []
synonym: "dihydric alcohol catabolism" BROAD []
synonym: "glycol breakdown" EXACT []
synonym: "glycol catabolism" EXACT []
synonym: "glycol degradation" EXACT []
is_a: GO:0034313 ! diol catabolic process
is_a: GO:0042844 ! glycol metabolic process

[Term]
id: GO:0042847
name: sorbose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sorbose, the ketohexose xylo-2-hexulose. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid." [ISBN:0198506732]
subset: gosubset_prok
synonym: "sorbose anabolism" EXACT []
synonym: "sorbose biosynthesis" EXACT []
synonym: "sorbose formation" EXACT []
synonym: "sorbose synthesis" EXACT []
is_a: GO:0019311 ! sorbose metabolic process
is_a: GO:0019319 ! hexose biosynthetic process

[Term]
id: GO:0042848
name: sorbose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of sorbose, the ketohexose xylo-2-hexulose. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid." [ISBN:0198506732]
subset: gosubset_prok
synonym: "sorbose breakdown" EXACT []
synonym: "sorbose catabolism" EXACT []
synonym: "sorbose degradation" EXACT []
is_a: GO:0019311 ! sorbose metabolic process
is_a: GO:0019320 ! hexose catabolic process

[Term]
id: GO:0042849
name: L-sorbose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-sorbose, the L-enantiomer of the ketohexose xylo-2-hexulose. L-sorbose is formed by bacterial oxidation of sorbitol." [CHEBI:17266, GOC:jsg, GOC:mah, ISBN:0198506732]
subset: gosubset_prok
synonym: "L-sorbose anabolism" EXACT []
synonym: "L-sorbose biosynthesis" EXACT []
synonym: "L-sorbose formation" EXACT []
synonym: "L-sorbose synthesis" EXACT []
is_a: GO:0019312 ! L-sorbose metabolic process
is_a: GO:0042847 ! sorbose biosynthetic process

[Term]
id: GO:0042850
name: L-sorbose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-sorbose, the L-enantiomer of the ketohexose xylo-2-hexulose." [CHEBI:17266, GOC:jsg, GOC:mah, ISBN:0198506732]
subset: gosubset_prok
synonym: "L-sorbose breakdown" EXACT []
synonym: "L-sorbose catabolism" EXACT []
synonym: "L-sorbose degradation" EXACT []
is_a: GO:0019312 ! L-sorbose metabolic process
is_a: GO:0042848 ! sorbose catabolic process

[Term]
id: GO:0042851
name: L-alanine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid." [CHEBI:16977, GOC:jl, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "L-alanine metabolism" EXACT []
is_a: GO:0006522 ! alanine metabolic process

[Term]
id: GO:0042852
name: L-alanine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid." [CHEBI:16977, GOC:jl, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "L-alanine anabolism" EXACT []
synonym: "L-alanine biosynthesis" EXACT []
synonym: "L-alanine formation" EXACT []
synonym: "L-alanine synthesis" EXACT []
is_a: GO:0006523 ! alanine biosynthetic process
is_a: GO:0042851 ! L-alanine metabolic process

[Term]
id: GO:0042853
name: L-alanine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid." [CHEBI:16977, GOC:jl, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "L-alanine breakdown" EXACT []
synonym: "L-alanine catabolism" EXACT []
synonym: "L-alanine degradation" EXACT []
is_a: GO:0006524 ! alanine catabolic process
is_a: GO:0042851 ! L-alanine metabolic process

[Term]
id: GO:0042854
name: eugenol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving eugenol, a colorless, aromatic, liquid hydrocarbon (C10H12O2) found in clove oil." [CHEBI:4917, GOC:jl]
subset: gosubset_prok
synonym: "4-allyl-2-methoxyphenol metabolic process" EXACT []
synonym: "4-allyl-2-methoxyphenol metabolism" EXACT []
synonym: "eugenic acid metabolic process" EXACT []
synonym: "eugenic acid metabolism" EXACT []
synonym: "eugenol metabolism" EXACT []
is_a: GO:0009698 ! phenylpropanoid metabolic process
is_a: GO:0018904 ! ether metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:0042855
name: eugenol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of eugenol, a colorless, aromatic, liquid hydrocarbon (C10H12O2) found in clove oil." [CHEBI:4917, GOC:jl]
subset: gosubset_prok
synonym: "4-allyl-2-methoxyphenol biosynthesis" EXACT []
synonym: "4-allyl-2-methoxyphenol biosynthetic process" EXACT []
synonym: "eugenic acid biosynthesis" EXACT []
synonym: "eugenic acid biosynthetic process" EXACT []
synonym: "eugenol anabolism" EXACT []
synonym: "eugenol biosynthesis" EXACT []
synonym: "eugenol formation" EXACT []
synonym: "eugenol synthesis" EXACT []
is_a: GO:0009699 ! phenylpropanoid biosynthetic process
is_a: GO:0042854 ! eugenol metabolic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:1901503 ! ether biosynthetic process

[Term]
id: GO:0042856
name: eugenol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of eugenol, a colorless, aromatic, liquid hydrocarbon (C10H12O2) found in clove oil." [CHEBI:4917, GOC:jl]
subset: gosubset_prok
synonym: "4-allyl-2-methoxyphenol catabolic process" EXACT []
synonym: "4-allyl-2-methoxyphenol catabolism" EXACT []
synonym: "eugenic acid catabolic process" EXACT []
synonym: "eugenic acid catabolism" EXACT []
synonym: "eugenol breakdown" EXACT []
synonym: "eugenol catabolism" EXACT []
synonym: "eugenol degradation" EXACT []
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0042854 ! eugenol metabolic process
is_a: GO:0046271 ! phenylpropanoid catabolic process
is_a: GO:1901502 ! ether catabolic process

[Term]
id: GO:0042857
name: chrysobactin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine)." [GOC:jl, PMID:8837459]
subset: gosubset_prok
synonym: "chrysobactin metabolism" EXACT []
is_a: GO:0006082 ! organic acid metabolic process
is_a: GO:0006518 ! peptide metabolic process
is_a: GO:0009237 ! siderophore metabolic process
is_a: GO:0009712 ! catechol-containing compound metabolic process
is_a: GO:0034308 ! primary alcohol metabolic process
is_a: GO:1901160 ! primary amino compound metabolic process

[Term]
id: GO:0042858
name: chrysobactin biosynthetic process
namespace: biological_process
alt_id: GO:0031183
alt_id: GO:0031184
def: "The chemical reactions and pathways resulting in the formation of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine)." [GOC:jl, PMID:8837459]
subset: gosubset_prok
synonym: "chrysobactin anabolism" EXACT []
synonym: "chrysobactin biosynthesis" EXACT []
synonym: "chrysobactin biosynthetic process, peptide formation" NARROW []
synonym: "chrysobactin biosynthetic process, peptide modification" NARROW []
synonym: "chrysobactin formation" EXACT []
synonym: "chrysobactin synthesis" EXACT []
is_a: GO:0009713 ! catechol-containing compound biosynthetic process
is_a: GO:0016053 ! organic acid biosynthetic process
is_a: GO:0019290 ! siderophore biosynthetic process
is_a: GO:0034309 ! primary alcohol biosynthetic process
is_a: GO:0042857 ! chrysobactin metabolic process
is_a: GO:1901162 ! primary amino compound biosynthetic process

[Term]
id: GO:0042859
name: chrysobactin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine)." [GOC:jl, PMID:8837459]
subset: gosubset_prok
synonym: "chrysobactin breakdown" EXACT []
synonym: "chrysobactin catabolism" EXACT []
synonym: "chrysobactin degradation" EXACT []
is_a: GO:0016054 ! organic acid catabolic process
is_a: GO:0019614 ! catechol-containing compound catabolic process
is_a: GO:0034310 ! primary alcohol catabolic process
is_a: GO:0042857 ! chrysobactin metabolic process
is_a: GO:0043171 ! peptide catabolic process
is_a: GO:0046215 ! siderophore catabolic process
is_a: GO:1901161 ! primary amino compound catabolic process

[Term]
id: GO:0042860
name: achromobactin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving achromobactin, a citrate siderophore." [GOC:jl, PMID:10928541]
subset: gosubset_prok
synonym: "achromobactin metabolism" EXACT []
is_a: GO:0009237 ! siderophore metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0042861
name: achromobactin biosynthetic process
namespace: biological_process
alt_id: GO:0031181
alt_id: GO:0031182
def: "The chemical reactions and pathways resulting in the formation of achromobactin, a citrate siderophore." [GOC:jl, PMID:10928541]
subset: gosubset_prok
synonym: "achromobactin anabolism" EXACT []
synonym: "achromobactin biosynthesis" EXACT []
synonym: "achromobactin biosynthetic process, peptide formation" NARROW []
synonym: "achromobactin biosynthetic process, peptide modification" NARROW []
synonym: "achromobactin formation" EXACT []
synonym: "achromobactin synthesis" EXACT []
is_a: GO:0019290 ! siderophore biosynthetic process
is_a: GO:0042860 ! achromobactin metabolic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process

[Term]
id: GO:0042862
name: achromobactin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of achromobactin, a citrate siderophore." [GOC:jl, PMID:10928541]
subset: gosubset_prok
synonym: "achromobactin breakdown" EXACT []
synonym: "achromobactin catabolism" EXACT []
synonym: "achromobactin degradation" EXACT []
is_a: GO:0042860 ! achromobactin metabolic process
is_a: GO:0046215 ! siderophore catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process

[Term]
id: GO:0042863
name: pyochelin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the siderochrome pyochelin (2-(2-o-hydroxyphenyl-2-thiazolin-4-yl)-3-methylthiazolidine-4-carboxylic acid)." [GOC:jl, PMID:6794030]
subset: gosubset_prok
synonym: "pyochelin metabolism" EXACT []
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0009237 ! siderophore metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process

[Term]
id: GO:0042864
name: pyochelin biosynthetic process
namespace: biological_process
alt_id: GO:0031187
alt_id: GO:0031188
def: "The chemical reactions and pathways resulting in the formation of the siderochrome pyochelin (2-(2-o-hydroxyphenyl-2-thiazolin-4-yl)-3-methylthiazolidine-4-carboxylic acid)." [GOC:jl, PMID:6794030]
subset: gosubset_prok
synonym: "pyochelin anabolism" EXACT []
synonym: "pyochelin biosynthesis" EXACT []
synonym: "pyochelin biosynthetic process, peptide formation" NARROW []
synonym: "pyochelin biosynthetic process, peptide modification" NARROW []
synonym: "pyochelin formation" EXACT []
synonym: "pyochelin synthesis" EXACT []
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0019290 ! siderophore biosynthetic process
is_a: GO:0042863 ! pyochelin metabolic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process

[Term]
id: GO:0042865
name: pyochelin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the siderochrome pyochelin (2-(2-o-hydroxyphenyl-2-thiazolin-4-yl)-3-methylthiazolidine-4-carboxylic acid)." [GOC:jl, PMID:6794030]
subset: gosubset_prok
synonym: "pyochelin breakdown" EXACT []
synonym: "pyochelin catabolism" EXACT []
synonym: "pyochelin degradation" EXACT []
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0042863 ! pyochelin metabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0046215 ! siderophore catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process

[Term]
id: GO:0042866
name: pyruvate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyruvate, 2-oxopropanoate." [GOC:go_curators]
subset: gosubset_prok
synonym: "pyruvate anabolism" EXACT []
synonym: "pyruvate biosynthesis" EXACT []
synonym: "pyruvate formation" EXACT []
synonym: "pyruvate synthesis" EXACT []
is_a: GO:0006090 ! pyruvate metabolic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process

[Term]
id: GO:0042867
name: pyruvate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pyruvate, 2-oxopropanoate." [GOC:go_curators]
subset: gosubset_prok
synonym: "pyruvate breakdown" EXACT []
synonym: "pyruvate catabolism" EXACT []
synonym: "pyruvate degradation" EXACT []
is_a: GO:0006090 ! pyruvate metabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0042868
name: antisense RNA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis." [GOC:jl]
subset: gosubset_prok
synonym: "antisense RNA metabolism" EXACT []
is_a: GO:0034660 ! ncRNA metabolic process

[Term]
id: GO:0042869
name: aldarate transport
namespace: biological_process
def: "The directed movement of aldarate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0006835 ! dicarboxylic acid transport
is_a: GO:0008643 ! carbohydrate transport

[Term]
id: GO:0042870
name: D-glucarate transport
namespace: biological_process
def: "The directed movement of D-glucarate, the D-enantiomer of glucarate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, GOC:jsg, GOC:mah, ISBN:0198506732]
is_a: GO:0042869 ! aldarate transport

[Term]
id: GO:0042873
name: aldonate transport
namespace: biological_process
def: "The directed movement of aldonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]
subset: gosubset_prok
is_a: GO:0008643 ! carbohydrate transport
is_a: GO:0015718 ! monocarboxylic acid transport

[Term]
id: GO:0042874
name: D-glucuronate transport
namespace: biological_process
def: "The directed movement of D-glucuronate, the D-enantiomer of glucuronate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, GOC:jsg, GOC:mah]
is_a: GO:0015738 ! glucuronate transport

[Term]
id: GO:0042875
name: D-galactonate transport
namespace: biological_process
def: "The directed movement of D-galactonate, the D-enantiomer of galactonate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, GOC:jsg, GOC:mah]
subset: gosubset_prok
is_a: GO:0042873 ! aldonate transport

[Term]
id: GO:0042876
name: aldarate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of aldarate from one side of the membrane to the other." [GOC:go_curators, PMID:15034926]
subset: gosubset_prok
is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity
is_a: GO:0015144 ! carbohydrate transmembrane transporter activity
relationship: part_of GO:0042869 ! aldarate transport

[Term]
id: GO:0042878
name: D-glucarate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of D-glucarate, the D-enantiomer of glucarate, from one side of the membrane to the other." [GOC:jl, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0042876 ! aldarate transmembrane transporter activity
relationship: part_of GO:0042870 ! D-glucarate transport

[Term]
id: GO:0042879
name: aldonate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of aldonate from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:0015144 ! carbohydrate transmembrane transporter activity
relationship: part_of GO:0042873 ! aldonate transport

[Term]
id: GO:0042880
name: D-glucuronate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of D-glucuronate, the D-enantiomer of glucuronate, from one side of the membrane to the other." [GOC:jl, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0015135 ! glucuronate transmembrane transporter activity
relationship: part_of GO:0042874 ! D-glucuronate transport

[Term]
id: GO:0042881
name: D-galactonate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of D-galactonate, the D-enantiomer of galactonate, from one side of the membrane to the other." [GOC:jl, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
is_a: GO:0042879 ! aldonate transmembrane transporter activity
relationship: part_of GO:0042875 ! D-galactonate transport

[Term]
id: GO:0042882
name: L-arabinose transport
namespace: biological_process
def: "The directed movement of L-arabinose, the L-enantiomer of arabinose, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, GOC:jsg, GOC:mah, ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0015751 ! arabinose transport

[Term]
id: GO:0042883
name: cysteine transport
namespace: biological_process
def: "The directed movement of cysteine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "L-cysteine transport" NARROW []
is_a: GO:0000101 ! sulfur amino acid transport
is_a: GO:0006812 ! cation transport
is_a: GO:0015804 ! neutral amino acid transport

[Term]
id: GO:0042884
name: microcin transport
namespace: biological_process
def: "The directed movement of microcin, a class of glycine-rich, bactericidal peptides (antibiotics) produced by some enteric bacteria, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, ISBN:0198506732, PMID:11292337]
subset: gosubset_prok
is_a: GO:0015833 ! peptide transport
is_a: GO:0042891 ! antibiotic transport

[Term]
id: GO:0042885
name: microcin B17 transport
namespace: biological_process
def: "The directed movement of microcin B17, a bactericidal peptide (antibiotic) produced by some enteric bacteria, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, PMID:11292337]
subset: gosubset_prok
is_a: GO:0042884 ! microcin transport

[Term]
id: GO:0042886
name: amide transport
namespace: biological_process
def: "The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0044765 ! single-organism transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0042887
name: amide transmembrane transporter activity
namespace: molecular_function
def: "Enables directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, from one side of the membrane to the other." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "amine/amide/polyamine channel activity" NARROW []
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity
relationship: part_of GO:0042886 ! amide transport

[Term]
id: GO:0042888
name: molybdenum ion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of molybdenum (Mo) ions from one side of a membrane to the other." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0046915 ! transition metal ion transmembrane transporter activity

[Term]
id: GO:0042889
name: 3-phenylpropionic acid transport
namespace: biological_process
def: "The directed movement of 3-phenylpropionic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]
subset: gosubset_prok
synonym: "3-phenylpropionate transport" EXACT []
synonym: "HCA transport" EXACT []
synonym: "hydrocinnamic acid transport" EXACT []
is_a: GO:0015718 ! monocarboxylic acid transport

[Term]
id: GO:0042890
name: 3-phenylpropionic acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of 3-phenylpropionic acid from one side of the membrane to the other." [GOC:jl]
synonym: "3-phenylpropionate acid transporter activity" EXACT []
synonym: "HCA transporter activity" EXACT []
synonym: "hydrocinnamic acid transporter activity" EXACT []
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
relationship: part_of GO:0042889 ! 3-phenylpropionic acid transport

[Term]
id: GO:0042891
name: antibiotic transport
namespace: biological_process
def: "The directed movement of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]
subset: gosubset_prok
is_a: GO:0015893 ! drug transport
is_a: GO:1901998 ! toxin transport

[Term]
id: GO:0042892
name: chloramphenicol transport
namespace: biological_process
def: "The directed movement of chloramphenicol, a broad-spectrum antibiotic that inhibits bacterial protein synthesis, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:17698, GOC:jl]
subset: gosubset_prok
is_a: GO:0015791 ! polyol transport
is_a: GO:0042886 ! amide transport
is_a: GO:0042891 ! antibiotic transport

[Term]
id: GO:0042893
name: polymyxin transport
namespace: biological_process
def: "The directed movement of polymyxin, any of a group of related antibiotics produced by Bacillus polymyxa and active against most Gram-negative bacteria, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0006869 ! lipid transport
is_a: GO:0015833 ! peptide transport
is_a: GO:0042891 ! antibiotic transport

[Term]
id: GO:0042894
name: fosmidomycin transport
namespace: biological_process
def: "The directed movement of fosmidomycin, a phosphonic acid derivative with potent activity against Gram-negative organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, PMID:12543685]
subset: gosubset_prok
is_a: GO:0042886 ! amide transport
is_a: GO:0042891 ! antibiotic transport
is_a: GO:0071702 ! organic substance transport

[Term]
id: GO:0042895
name: antibiotic transporter activity
namespace: molecular_function
def: "Enables the directed movement of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms, into, out of or within a cell, or between cells." [GOC:jl]
subset: gosubset_prok
is_a: GO:0019534 ! toxin transporter activity
is_a: GO:0090484 ! drug transporter activity
relationship: part_of GO:0042891 ! antibiotic transport

[Term]
id: GO:0042896
name: chloramphenicol transporter activity
namespace: molecular_function
def: "Enables the directed movement of chloramphenicol, a broad-spectrum antibiotic that inhibits bacterial protein synthesis, into, out of or within a cell, or between cells." [CHEBI:17698, GOC:jl]
subset: gosubset_prok
is_a: GO:0042895 ! antibiotic transporter activity
relationship: part_of GO:0042892 ! chloramphenicol transport

[Term]
id: GO:0042897
name: polymyxin transporter activity
namespace: molecular_function
def: "Enables the directed movement of polymyxin, any of a group of related antibiotics produced by Bacillus polymyxa and active against most Gram-negative bacteria, into, out of or within a cell, or between cells." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0005319 ! lipid transporter activity
is_a: GO:0015197 ! peptide transporter activity
is_a: GO:0042895 ! antibiotic transporter activity
relationship: part_of GO:0042893 ! polymyxin transport

[Term]
id: GO:0042898
name: fosmidomycin transporter activity
namespace: molecular_function
def: "Enables the directed movement of fosmidomycin, a phosphonic acid derivative with potent activity against Gram-negative organisms, into, out of or within a cell, or between cells." [GOC:jl, PMID:12543685]
subset: gosubset_prok
is_a: GO:0042895 ! antibiotic transporter activity
relationship: part_of GO:0042894 ! fosmidomycin transport

[Term]
id: GO:0042899
name: arabinan transport
namespace: biological_process
def: "The directed movement of arabinan, a polysaccharide composed of arabinose residues, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]
subset: gosubset_prok
is_a: GO:0015751 ! arabinose transport
is_a: GO:0015774 ! polysaccharide transport

[Term]
id: GO:0042900
name: arabinose transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of arabinose, a pentose monosaccharide that occurs in both D and L configurations, and as a polymer, from one side of the membrane to the other." [CHEBI:22599, GOC:jl, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0015146 ! pentose transmembrane transporter activity
relationship: part_of GO:0015751 ! arabinose transport

[Term]
id: GO:0042901
name: arabinan transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of an arabinan, a polysaccharide composed of arabinose residues, from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015159 ! polysaccharide transmembrane transporter activity
is_a: GO:0042900 ! arabinose transmembrane transporter activity

[Term]
id: GO:0042902
name: peptidoglycan-protein cross-linking via L-threonyl-pentaglycyl-murein
namespace: biological_process
def: "The process of linking a protein to peptidoglycan via a carboxy terminal threonine carboxyl group through a pentaglycyl peptide to the lysine or diaminopimelic acid of the peptidoglycan." [RESID:AA0345]
subset: gosubset_prok
xref: RESID:AA0345
is_a: GO:0018104 ! peptidoglycan-protein cross-linking
is_a: GO:0018210 ! peptidyl-threonine modification

[Term]
id: GO:0042903
name: tubulin deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl(alpha-tubulin) + H2O = alpha-tubulin + acetate." [PMID:12024216, PMID:12486003]
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0033558 ! protein deacetylase activity
relationship: part_of GO:0090042 ! tubulin deacetylation

[Term]
id: GO:0042904
name: 9-cis-retinoic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 9-cis-retinoic acid, a metabolically active vitamin A derivative." [GOC:jl, PMID:11279029]
subset: gosubset_prok
synonym: "9-cis-retinoic acid anabolism" EXACT []
synonym: "9-cis-retinoic acid biosynthesis" EXACT []
synonym: "9-cis-retinoic acid formation" EXACT []
synonym: "9-cis-retinoic acid synthesis" EXACT []
is_a: GO:0002138 ! retinoic acid biosynthetic process
is_a: GO:0042905 ! 9-cis-retinoic acid metabolic process

[Term]
id: GO:0042905
name: 9-cis-retinoic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 9-cis-retinoic acid, a metabolically active vitamin A derivative." [GOC:jl, PMID:11279029]
subset: gosubset_prok
synonym: "9-cis-retinoic acid metabolism" EXACT []
is_a: GO:0042573 ! retinoic acid metabolic process

[Term]
id: GO:0042906
name: xanthine transport
namespace: biological_process
def: "The directed movement of xanthine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Xanthine (2,6-dihydroxypurine) is a purine formed in the metabolic breakdown of guanine, but is not present in nucleic acids." [GOC:jl]
synonym: "xanthine transmembrane transport" EXACT [GOC:mah]
is_a: GO:0006863 ! purine nucleobase transport

[Term]
id: GO:0042907
name: xanthine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of xanthine from one side of a membrane to the other. Xanthine (2,6-dihydroxypurine) is a purine formed in the metabolic breakdown of guanine, but is not present in nucleic acids." [GOC:jl]
is_a: GO:0005345 ! purine nucleobase transmembrane transporter activity
relationship: part_of GO:0042906 ! xanthine transport

[Term]
id: GO:0042908
name: xenobiotic transport
namespace: biological_process
def: "The directed movement of a xenobiotic, a compound foreign to living organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0044765 ! single-organism transport

[Term]
id: GO:0042909
name: acridine transport
namespace: biological_process
def: "The directed movement of acridine (10-azaanthracene), a heterocyclic ring compound found in crude coal-tar anthracene, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:36420, GOC:jl, Wikipedia:Acridine]
subset: gosubset_prok
is_a: GO:0042908 ! xenobiotic transport
is_a: GO:0071702 ! organic substance transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0042910
name: xenobiotic transporter activity
namespace: molecular_function
def: "Enables the directed movement of a xenobiotic, a compound foreign to living organisms, into, out of or within a cell, or between cells." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0005215 ! transporter activity
relationship: part_of GO:0042908 ! xenobiotic transport

[Term]
id: GO:0042911
name: acridine transporter activity
namespace: molecular_function
def: "Enables the directed movement of acridine (10-azaanthracene), a heterocyclic ring compound found in crude coal-tar anthracene, into, out of or within a cell, or between cells." [CHEBI:36420, GOC:jl]
subset: gosubset_prok
is_a: GO:0042910 ! xenobiotic transporter activity
relationship: part_of GO:0042909 ! acridine transport

[Term]
id: GO:0042912
name: colicin transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a colicin from one side of a membrane to the other. Colicins are a group of antibiotics produced by E. coli and related species that are encoded by a group of naturally occurring plasmids, e.g. Col E1." [GOC:jl, GOC:mtg_transport, ISBN:0815340729, PMID:17347522]
subset: gosubset_prok
is_a: GO:0022885 ! bacteriocin transmembrane transporter activity

[Term]
id: GO:0042913
name: group A colicin transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of group A colicins (colicins E1, E2, E3, A, K, and N) from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729, PMID:9171417]
subset: gosubset_prok
is_a: GO:0042912 ! colicin transmembrane transporter activity

[Term]
id: GO:0042914
name: colicin transport
namespace: biological_process
def: "The directed movement of a colicin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Colicins are a group of antibiotics produced by E. coli and related species that are encoded by a group of naturally occurring plasmids, e.g. Col E1." [GOC:jl, PMID:17347522]
subset: gosubset_prok
is_a: GO:0043213 ! bacteriocin transport

[Term]
id: GO:0042915
name: group A colicin transport
namespace: biological_process
def: "The directed movement of group A colicins (colicins E1, E2, E3, A, K, and N) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, PMID:9171417]
subset: gosubset_prok
is_a: GO:0042914 ! colicin transport

[Term]
id: GO:0042916
name: alkylphosphonate transport
namespace: biological_process
def: "The directed movement of an alkylphosphonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0015716 ! organic phosphonate transport

[Term]
id: GO:0042917
name: alkylphosphonate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of an alkylphosphonate from one side of a membrane to the other." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0015604 ! organic phosphonate transmembrane transporter activity

[Term]
id: GO:0042918
name: alkanesulfonate transport
namespace: biological_process
def: "The directed movement of an alkanesulfonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Alkanesulfonates are organic esters or salts of sulfonic acid containing an aliphatic hydrocarbon radical." [CHEBI:22318, GOC:jl]
subset: gosubset_prok
synonym: "alkanesulphonate transport" EXACT []
is_a: GO:0015711 ! organic anion transport
is_a: GO:0042908 ! xenobiotic transport
is_a: GO:0072348 ! sulfur compound transport

[Term]
id: GO:0042919
name: benzoate transport
namespace: biological_process
def: "The directed movement of benzoate, the anion of benzoic acid (benzenecarboxylic acid) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, ISBN:0721662544]
subset: gosubset_prok
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0042908 ! xenobiotic transport

[Term]
id: GO:0042920
name: 3-hydroxyphenylpropionic acid transport
namespace: biological_process
def: "The directed movement of 3-hydroxyphenylpropionic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators]
subset: gosubset_prok
synonym: "3-(3-hydroxyphenyl)propionic acid transport" EXACT []
synonym: "m-hydroxyphenylpropionic acid transport" EXACT []
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0042908 ! xenobiotic transport

[Term]
id: GO:0042921
name: glucocorticoid receptor signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of a glucocorticoid binding to its receptor." [GOC:mah]
synonym: "glucocorticoid receptor signalling pathway" EXACT []
is_a: GO:0031958 ! corticosteroid receptor signaling pathway

[Term]
id: GO:0042922
name: neuromedin U receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with one or more specific sites on a neuromedin U receptor." [GOC:jl, PMID:10899166]
is_a: GO:0071855 ! neuropeptide receptor binding

[Term]
id: GO:0042923
name: neuropeptide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators)." [http://www.wormbook.org/chapters/www_neuropeptides/neuropeptides.html]
is_a: GO:0042277 ! peptide binding

[Term]
id: GO:0042924
name: neuromedin U binding
namespace: molecular_function
def: "Interacting selectively and non-covalently and stoichiometrically with neuromedin U, a hypothalamic peptide involved in energy homeostasis and stress responses." [GOC:jl, PMID:12584108]
synonym: "NMU binding" EXACT []
is_a: GO:0042923 ! neuropeptide binding

[Term]
id: GO:0042925
name: benzoate transporter activity
namespace: molecular_function
def: "Enables the directed movement of benzoate, the anion of benzoic acid (benzenecarboxylic acid) into, out of or within a cell, or between cells." [GOC:jl, ISBN:0721662544]
subset: gosubset_prok
xref: RHEA:32814
is_a: GO:0042910 ! xenobiotic transporter activity
relationship: part_of GO:0042919 ! benzoate transport

[Term]
id: GO:0042926
name: 3-hydroxyphenylpropionic acid transporter activity
namespace: molecular_function
def: "Enables the directed movement of 3-hydroxyphenylpropionic acid into, out of or within a cell, or between cells." [GOC:jl]
subset: gosubset_prok
synonym: "3-(3-hydroxyphenyl)propionic acid transporter activity" EXACT []
synonym: "m-hydroxyphenylpropionic acid transporter activity" EXACT []
is_a: GO:0042910 ! xenobiotic transporter activity
relationship: part_of GO:0042920 ! 3-hydroxyphenylpropionic acid transport

[Term]
id: GO:0042927
name: siderophore transporter activity
namespace: molecular_function
def: "Enables the directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of or within a cell, or between cells." [GOC:go_curators]
subset: gosubset_prok
synonym: "siderochrome transporter activity" NARROW []
synonym: "siderophore-iron transporter activity" RELATED []
is_a: GO:0005215 ! transporter activity
relationship: part_of GO:0015891 ! siderophore transport

[Term]
id: GO:0042928
name: ferrichrome transport
namespace: biological_process
def: "The directed movement of a ferrichrome into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0015687 ! ferric-hydroxamate transport
is_a: GO:0015833 ! peptide transport

[Term]
id: GO:0042929
name: ferrichrome transporter activity
namespace: molecular_function
def: "Enables the directed movement of a ferrichrome into, out of or within a cell, or between cells. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0015197 ! peptide transporter activity
is_a: GO:0042927 ! siderophore transporter activity
relationship: part_of GO:0042928 ! ferrichrome transport

[Term]
id: GO:0042930
name: enterobactin transport
namespace: biological_process
def: "The directed movement of the siderochrome enterobactin, a cyclic trimer of 2, 3 dihydroxybenzoylserine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:28855, GOC:jl]
subset: gosubset_prok
synonym: "enterochelin transport" EXACT []
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0015891 ! siderophore transport

[Term]
id: GO:0042931
name: enterobactin transporter activity
namespace: molecular_function
def: "Enables the directed movement of the siderochrome enterochelin, a cyclic trimer of 2, 3 dihydroxybenzoylserine into, out of or within a cell, or between cells." [CHEBI:28855, GOC:jl]
subset: gosubset_prok
synonym: "enterochelin transporter activity" EXACT []
is_a: GO:0042927 ! siderophore transporter activity
relationship: part_of GO:0042930 ! enterobactin transport

[Term]
id: GO:0042932
name: chrysobactin transport
namespace: biological_process
def: "The directed movement of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, PMID:8837459]
subset: gosubset_prok
is_a: GO:0015849 ! organic acid transport
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0015891 ! siderophore transport
is_a: GO:0042938 ! dipeptide transport

[Term]
id: GO:0042933
name: chrysobactin transporter activity
namespace: molecular_function
def: "Enables the directed movement of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine) into, out of or within a cell, or between cells." [GOC:jl, PMID:8837459]
subset: gosubset_prok
is_a: GO:0042927 ! siderophore transporter activity
is_a: GO:0042936 ! dipeptide transporter activity
relationship: part_of GO:0042932 ! chrysobactin transport

[Term]
id: GO:0042934
name: achromobactin transporter activity
namespace: molecular_function
def: "Enables the directed movement of achromobactin, a citrate siderophore, into, out of or within a cell, or between cells." [GOC:jl]
subset: gosubset_prok
is_a: GO:0042927 ! siderophore transporter activity
is_a: GO:0051184 ! cofactor transporter activity
relationship: part_of GO:0042935 ! achromobactin transport

[Term]
id: GO:0042935
name: achromobactin transport
namespace: biological_process
def: "The directed movement of achromobactin, a citrate siderophore, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, PMID:10928541]
subset: gosubset_prok
is_a: GO:0015891 ! siderophore transport
is_a: GO:0046942 ! carboxylic acid transport
is_a: GO:0051181 ! cofactor transport

[Term]
id: GO:0042936
name: dipeptide transporter activity
namespace: molecular_function
def: "Enables the directed movement of a dipeptide, a combination of two amino acids by means of a peptide (-CO-NH-) link, into, out of or within a cell, or between cells." [CHEBI:46761, GOC:jl]
subset: gosubset_prok
is_a: GO:0015198 ! oligopeptide transporter activity
relationship: part_of GO:0042938 ! dipeptide transport

[Term]
id: GO:0042937
name: tripeptide transporter activity
namespace: molecular_function
def: "Enables the directed movement of a tripeptide, a compound containing three amino acids linked together by peptide bonds, into, out of or within a cell, or between cells." [CHEBI:47923, GOC:jl]
subset: gosubset_prok
is_a: GO:0015198 ! oligopeptide transporter activity
relationship: part_of GO:0042939 ! tripeptide transport

[Term]
id: GO:0042938
name: dipeptide transport
namespace: biological_process
def: "The directed movement of a dipeptide, a combination of two amino acids by means of a peptide (-CO-NH-) link, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:46761, GOC:jl]
subset: gosubset_prok
is_a: GO:0006857 ! oligopeptide transport

[Term]
id: GO:0042939
name: tripeptide transport
namespace: biological_process
def: "The directed movement of a tripeptide, a compound containing three amino acids linked together by peptide bonds, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:47923, GOC:jl]
subset: gosubset_prok
is_a: GO:0006857 ! oligopeptide transport

[Term]
id: GO:0042940
name: D-amino acid transport
namespace: biological_process
def: "The directed movement of the D-enantiomer of an amino acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, GOC:jsg, GOC:mah]
subset: gosubset_prok
is_a: GO:0006865 ! amino acid transport

[Term]
id: GO:0042941
name: D-alanine transport
namespace: biological_process
def: "The directed movement of D-alanine, the D-enantiomer of 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:15570, GOC:jl, GOC:jsg, GOC:mah]
subset: gosubset_prok
is_a: GO:0032328 ! alanine transport
is_a: GO:0042940 ! D-amino acid transport

[Term]
id: GO:0042942
name: D-serine transport
namespace: biological_process
def: "The directed movement of D-serine, the D-enantiomer of 2-amino-3-hydroxypropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, GOC:jsg, GOC:mah]
subset: gosubset_prok
is_a: GO:0032329 ! serine transport
is_a: GO:0042940 ! D-amino acid transport

[Term]
id: GO:0042943
name: D-amino acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of D-amino acids from one side of a membrane to the other. D-amino acids are the D-enantiomers of amino acids." [GOC:jl, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "D-amino acid transporter activity" BROAD []
is_a: GO:0015171 ! amino acid transmembrane transporter activity
relationship: part_of GO:0042940 ! D-amino acid transport

[Term]
id: GO:0042944
name: D-alanine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of D-alanine from one side of a membrane to the other. D-alanine is the D-enantiomer of 2-aminopropanoic acid." [CHEBI:15570, GOC:jl, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "D-alanine transporter activity" BROAD []
is_a: GO:0022858 ! alanine transmembrane transporter activity
is_a: GO:0042943 ! D-amino acid transmembrane transporter activity
relationship: part_of GO:0042941 ! D-alanine transport

[Term]
id: GO:0042945
name: D-serine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of D-serine from one side of a membrane to the other. D-serine is the D-enantiomer of 2-amino-3-hydroxypropanoic acid." [GOC:jl, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "D-serine permease activity" EXACT []
synonym: "D-serine transporter activity" BROAD []
is_a: GO:0022889 ! serine transmembrane transporter activity
is_a: GO:0042943 ! D-amino acid transmembrane transporter activity
relationship: part_of GO:0042942 ! D-serine transport

[Term]
id: GO:0042946
name: glucoside transport
namespace: biological_process
def: "The directed movement of glucosides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glucosides are glycosides in which the sugar group is a glucose residue." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
is_a: GO:1901656 ! glycoside transport

[Term]
id: GO:0042947
name: glucoside transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of glucosides from one side of the membrane to the other. Glucosides are glycosides in which the sugar group is a glucose residue." [GOC:jl, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity
is_a: GO:1901505 ! carbohydrate derivative transporter activity
relationship: part_of GO:0042946 ! glucoside transport

[Term]
id: GO:0042948
name: salicin transport
namespace: biological_process
def: "The directed movement of salicin (saligenin-beta-D-glucopyranoside), a glucoside of o-hydroxybenzylalcohol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:17814, GOC:jl]
subset: gosubset_prok
is_a: GO:0015759 ! beta-glucoside transport
is_a: GO:0015850 ! organic hydroxy compound transport

[Term]
id: GO:0042949
name: arbutin transport
namespace: biological_process
def: "The directed movement of arbutin, a glycoside found in the bearberry and related plants which has been used to treat urinary-tract diseases, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, http://biotech.icmb.utexas.edu/]
is_a: GO:0015759 ! beta-glucoside transport

[Term]
id: GO:0042950
name: salicin transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of salicin (saligenin-beta-D-glucopyranoside), a glucoside of o-hydroxybenzylalcohol, from one side of the membrane to the other." [CHEBI:17814, GOC:jl, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0015573 ! beta-glucoside transmembrane transporter activity
is_a: GO:0015665 ! alcohol transmembrane transporter activity
relationship: part_of GO:0042948 ! salicin transport

[Term]
id: GO:0042951
name: arbutin transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of arbutin, a glycoside found in the bearberry and related plants which has been used to treat urinary-tract diseases, from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, http://biotech.icmb.utexas.edu/, ISBN:0815340729]
is_a: GO:0015573 ! beta-glucoside transmembrane transporter activity
relationship: part_of GO:0042949 ! arbutin transport

[Term]
id: GO:0042952
name: beta-ketoadipate pathway
namespace: biological_process
def: "A pathway of aromatic compound degradation by ortho-cleavage; one branch converts protocatechuate, derived from phenolic compounds, to beta-ketoadipate, and the other branch converts catechol, generated from various aromatic hydrocarbons, amino aromatics, and lignin monomers, also to beta-ketoadipate. Two additional steps accomplish the conversion of beta-ketoadipate to tricarboxylic acid cycle intermediates." [GOC:jl, PMID:8905091]
subset: gosubset_prok
synonym: "ortho-cleavage pathway" BROAD []
is_a: GO:0019439 ! aromatic compound catabolic process

[Term]
id: GO:0042953
name: lipoprotein transport
namespace: biological_process
def: "The directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0015031 ! protein transport
is_a: GO:0044765 ! single-organism transport
is_a: GO:0044872 ! lipoprotein localization

[Term]
id: GO:0042954
name: lipoprotein transporter activity
namespace: molecular_function
def: "Enables the directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0008565 ! protein transporter activity
relationship: part_of GO:0042953 ! lipoprotein transport

[Term]
id: GO:0042955
name: dextrin transport
namespace: biological_process
def: "The directed movement of dextrin, any one, or the mixture, of the intermediate polysaccharides formed during the hydrolysis of starch, which are dextrorotatory, soluble in water, and precipitable in alcohol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, http://www.mercksource.com/]
subset: gosubset_prok
is_a: GO:0015774 ! polysaccharide transport

[Term]
id: GO:0042956
name: maltodextrin transport
namespace: biological_process
def: "The directed movement of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, http://www.mercksource.com/]
subset: gosubset_prok
is_a: GO:0015774 ! polysaccharide transport

[Term]
id: GO:0042957
name: dextrin transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of dextrin, any one, or the mixture, of the intermediate polysaccharides formed during the hydrolysis of starch, which are dextrorotatory, soluble in water, and precipitable in alcohol, from one side of the membrane to the other." [GOC:jl, GOC:vk, http://www.mercksource.com/]
subset: gosubset_prok
is_a: GO:0015159 ! polysaccharide transmembrane transporter activity
relationship: part_of GO:0042955 ! dextrin transport

[Term]
id: GO:0042958
name: maltodextrin transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, from one side of the membrane to the other." [GOC:jl, http://www.mercksource.com/, PMID:15034926]
subset: gosubset_prok
is_a: GO:0015159 ! polysaccharide transmembrane transporter activity
relationship: part_of GO:0042956 ! maltodextrin transport

[Term]
id: GO:0042959
name: alkanesulfonate transporter activity
namespace: molecular_function
def: "Enables the directed movement of alkanesulfonate into, out of or within a cell, or between cells." [GOC:jl]
subset: gosubset_prok
synonym: "alkanesulphonate transporter activity" EXACT []
is_a: GO:0042910 ! xenobiotic transporter activity
relationship: part_of GO:0042918 ! alkanesulfonate transport

[Term]
id: GO:0042960
name: antimonite secondary active transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of antimonite from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:jl]
subset: gosubset_prok
synonym: "antimonite porter activity" RELATED []
is_a: GO:0015104 ! antimonite transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0042961
name: antimonite-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + antimonite(in) = ADP + phosphate + antimonite(out)." [EC:3.6.3.16]
subset: gosubset_prok
synonym: "antimonite ABC transporter" NARROW []
is_a: GO:0042960 ! antimonite secondary active transmembrane transporter activity
is_a: GO:0043225 ! anion transmembrane-transporting ATPase activity

[Term]
id: GO:0042962
name: acridine:proton antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + acridine(in) = H+(in) + acridine(out)." [PMID:10735876]
subset: gosubset_prok
synonym: "acridine efflux pump activity" RELATED []
synonym: "acridine:hydrogen antiporter activity" EXACT []
is_a: GO:0015299 ! solute:proton antiporter activity
is_a: GO:0042911 ! acridine transporter activity

[Term]
id: GO:0042964
name: thioredoxin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of thioredoxin, a small disulfide-containing redox protein that serves as a general protein disulfide oxidoreductase." [GOC:go_curators]
subset: gosubset_prok
synonym: "thioredoxin anabolism" EXACT []
synonym: "thioredoxin biosynthesis" EXACT []
synonym: "thioredoxin formation" EXACT []
synonym: "thioredoxin synthesis" EXACT []
is_a: GO:0019538 ! protein metabolic process
is_a: GO:0034645 ! cellular macromolecule biosynthetic process

[Term]
id: GO:0042965
name: glutaredoxin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a small disulfide-containing redox protein that serves as a glutathione-disulfide oxidoreductase." [GOC:go_curators]
subset: gosubset_prok
synonym: "glutaredoxin anabolism" EXACT []
synonym: "glutaredoxin biosynthesis" EXACT []
synonym: "glutaredoxin formation" EXACT []
synonym: "glutaredoxin synthesis" EXACT []
is_a: GO:0019538 ! protein metabolic process
is_a: GO:0034645 ! cellular macromolecule biosynthetic process

[Term]
id: GO:0042966
name: biotin carboxyl carrier protein biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the biotin carboxyl carrier protein, a subunit of acetyl-coenzyme A carboxylase." [GOC:go_curators, PMID:8102363]
subset: gosubset_prok
synonym: "BCCP biosynthesis" EXACT []
synonym: "BCCP biosynthetic process" EXACT []
synonym: "biotin carboxyl carrier protein anabolism" EXACT []
synonym: "biotin carboxyl carrier protein biosynthesis" EXACT []
synonym: "biotin carboxyl carrier protein formation" EXACT []
synonym: "biotin carboxyl carrier protein synthesis" EXACT []
is_a: GO:0009059 ! macromolecule biosynthetic process

[Term]
id: GO:0042967
name: acyl-carrier-protein biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of acyl-carrier protein." [GOC:go_curators]
subset: gosubset_prok
synonym: "ACP biosynthesis" EXACT []
synonym: "ACP biosynthetic process" EXACT []
synonym: "acyl carrier protein biosynthesis" EXACT []
synonym: "acyl carrier protein biosynthetic process" EXACT []
synonym: "acyl-carrier protein biosynthesis" EXACT []
synonym: "acyl-carrier-protein anabolism" EXACT []
synonym: "acyl-carrier-protein biosynthesis" EXACT []
synonym: "acyl-carrier-protein formation" EXACT []
synonym: "acyl-carrier-protein synthesis" EXACT []
is_a: GO:0019538 ! protein metabolic process
is_a: GO:0034645 ! cellular macromolecule biosynthetic process

[Term]
id: GO:0042968
name: homoserine transport
namespace: biological_process
def: "The directed movement of homoserine, alpha-amino-gamma-hydroxybutyric acid, an intermediate in the biosynthesis of cystathionine, threonine and methionine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0015804 ! neutral amino acid transport

[Term]
id: GO:0042969
name: lactone transport
namespace: biological_process
def: "The directed movement of lactone from one side of a membrane to the other. A lactone is a cyclic ester of a hydroxy carboxylic acid, containing a 1-oxacycloalkan-2-one structure, or an analogue having unsaturation or heteroatoms replacing one or more carbon atoms of the ring." [CHEBI:25000, GOC:go_curators]
subset: gosubset_prok
is_a: GO:0044765 ! single-organism transport
is_a: GO:0071702 ! organic substance transport

[Term]
id: GO:0042970
name: homoserine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of homoserine from one side of a membrane to the other. Homoserine is alpha-amino-gamma-hydroxybutyric acid, an intermediate in the biosynthesis of cystathionine, threonine and methionine." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "homoserine transporter activity" BROAD []
is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity
relationship: part_of GO:0042968 ! homoserine transport

[Term]
id: GO:0042971
name: lactone transmembrane transporter activity
namespace: molecular_function
def: "Enables the directed movement of lactone from one side of a membrane to the other. A lactone is a cyclic ester of a hydroxy carboxylic acid, containing a 1-oxacycloalkan-2-one structure, or an analogue having unsaturation or heteroatoms replacing one or more carbon atoms of the ring." [CHEBI:25000, GOC:go_curators]
subset: gosubset_prok
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity
relationship: part_of GO:0042969 ! lactone transport

[Term]
id: GO:0042972
name: licheninase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1->4)-beta-D-glucosidic linkages in beta-D-glucans containing (1->3) and (1->4) bonds." [EC:3.2.1.73]
subset: gosubset_prok
synonym: "1,3-1,4-beta-D-glucan 4-glucanohydrolase activity" EXACT []
synonym: "1,3-1,4-beta-glucan 4-glucanohydrolase activity" EXACT []
synonym: "1,3;1,4-beta-glucan 4-glucanohydrolase activity" EXACT [EC:3.2.1.73]
synonym: "1,3;1,4-beta-glucan endohydrolase activity" EXACT [EC:3.2.1.73]
synonym: "beta-(1->3), (1->4)-D-glucan 4-glucanohydrolase activity" EXACT [EC:3.2.1.73]
synonym: "beta-glucanase activity" BROAD [EC:3.2.1.73]
synonym: "endo-beta-1,3-1,4 glucanase activity" EXACT [EC:3.2.1.73]
synonym: "lichenase activity" EXACT []
synonym: "mixed linkage beta-glucanase activity" RELATED [EC:3.2.1.73]
xref: EC:3.2.1.73
xref: MetaCyc:3.2.1.73-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0042973
name: glucan endo-1,3-beta-D-glucosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1->3)-beta-D-glucosidic linkages in (1->3)-beta-D-glucans." [EC:3.2.1.39]
subset: gosubset_prok
synonym: "(1->3)-beta-glucan 3-glucanohydrolase activity" EXACT [EC:3.2.1.39]
synonym: "(1->3)-beta-glucan endohydrolase activity" EXACT [EC:3.2.1.39]
synonym: "1,3-beta-D-glucan 3-glucanohydrolase activity" EXACT [EC:3.2.1.39]
synonym: "1,3-beta-D-glucan glucanohydrolase activity" EXACT [EC:3.2.1.39]
synonym: "beta-1,3-glucanase" BROAD [EC:3.2.1.39]
synonym: "callase activity" EXACT [EC:3.2.1.39]
synonym: "endo-(1,3)-beta-D-glucanase activity" BROAD [EC:3.2.1.39]
synonym: "endo-(1->3)-beta-D-glucanase activity" BROAD [EC:3.2.1.39]
synonym: "endo-1,3-beta-D-glucanase" BROAD [EC:3.2.1.39]
synonym: "endo-1,3-beta-glucanase activity" BROAD []
synonym: "endo-1,3-beta-glucosidase activity" BROAD [EC:3.2.1.39]
synonym: "kitalase activity" EXACT [EC:3.2.1.39]
synonym: "laminaranase activity" BROAD []
synonym: "laminarinase activity" BROAD []
synonym: "oligo-1,3-glucosidase activity" RELATED [EC:3.2.1.39]
xref: EC:3.2.1.39
xref: MetaCyc:3.2.1.39-RXN
is_a: GO:0008422 ! beta-glucosidase activity

[Term]
id: GO:0042974
name: retinoic acid receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the retinoic acid receptor, a ligand-regulated transcription factor belonging to the nuclear receptor superfamily." [GOC:jl, PMID:12476796]
synonym: "RAR binding" EXACT []
is_a: GO:0008134 ! transcription factor binding
is_a: GO:0035257 ! nuclear hormone receptor binding

[Term]
id: GO:0042975
name: peroxisome proliferator activated receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any of the peroxisome proliferator activated receptors, alpha, beta or gamma." [GOC:jl, PMID:12769781]
synonym: "PPAR binding" EXACT []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0042976
name: activation of Janus kinase activity
namespace: biological_process
def: "The process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it." [GOC:jl, PMID:12479803]
synonym: "activation of JAK protein" EXACT [GOC:dph, GOC:tb]
synonym: "activation of JAK protein by tyrosine phosphorylation" EXACT []
synonym: "positive regulation of JAK protein activity by tyrosine phosphorylation" BROAD []
synonym: "tyrosine phosphorylation of JAK protein" RELATED []
is_a: GO:0018108 ! peptidyl-tyrosine phosphorylation
is_a: GO:0032147 ! activation of protein kinase activity
relationship: part_of GO:0046427 ! positive regulation of JAK-STAT cascade

[Term]
id: GO:0042977
name: activation of JAK2 kinase activity
namespace: biological_process
def: "The process of introducing a phosphate group to a tyrosine residue of a JAK2 (Janus Activated Kinase 2) protein, thereby activating it." [GOC:jl, PMID:12479803]
synonym: "activation of JAK2 protein" EXACT [GOC:dph, GOC:tb]
synonym: "tyrosine phosphorylation of JAK2 protein" RELATED []
is_a: GO:0042976 ! activation of Janus kinase activity

[Term]
id: GO:0042978
name: ornithine decarboxylase activator activity
namespace: molecular_function
def: "Upregulation of the activity of the enzyme ornithine decarboxylase." [GOC:jl]
synonym: "L-ornithine carboxy-lyase activator activity" NARROW []
is_a: GO:0008047 ! enzyme activator activity
is_a: GO:0042979 ! ornithine decarboxylase regulator activity
relationship: positively_regulates GO:0004586 ! ornithine decarboxylase activity

[Term]
id: GO:0042979
name: ornithine decarboxylase regulator activity
namespace: molecular_function
def: "Modulation of the activity of the enzyme ornithine decarboxylase." [GOC:jl]
is_a: GO:0030234 ! enzyme regulator activity
relationship: regulates GO:0004586 ! ornithine decarboxylase activity

[Term]
id: GO:0042980
name: obsolete cystic fibrosis transmembrane conductance regulator binding
namespace: molecular_function
def: "OBSOLETE. Interacting selectively and non-covalently with the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein." [GOC:jl]
comment: This term was made obsolete because it represents binding to an individual protein.
synonym: "CFTR binding" EXACT []
synonym: "cystic fibrosis transmembrane conductance regulator binding" EXACT []
is_obsolete: true
replaced_by: GO:0044325

[Term]
id: GO:0042981
name: regulation of apoptotic process
namespace: biological_process
def: "Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
comment: This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used.
synonym: "apoptosis regulator activity" RELATED []
synonym: "regulation of apoptosis" NARROW []
xref: Reactome:REACT_106248 "Regulation of Apoptosis, Mus musculus"
xref: Reactome:REACT_109234 "Regulation of Apoptosis, Rattus norvegicus"
xref: Reactome:REACT_109339 "Regulation of Apoptosis, Sus scrofa"
xref: Reactome:REACT_13648 "Regulation of Apoptosis, Homo sapiens"
xref: Reactome:REACT_29911 "Regulation of Apoptosis, Danio rerio"
xref: Reactome:REACT_30641 "Regulation of Apoptosis, Drosophila melanogaster"
xref: Reactome:REACT_79698 "Regulation of Apoptosis, Taeniopygia guttata"
xref: Reactome:REACT_85908 "Regulation of Apoptosis, Bos taurus"
xref: Reactome:REACT_86575 "Regulation of Apoptosis, Xenopus tropicalis"
xref: Reactome:REACT_95946 "Regulation of Apoptosis, Caenorhabditis elegans"
xref: Reactome:REACT_96201 "Regulation of Apoptosis, Canis familiaris"
xref: Reactome:REACT_99944 "Regulation of Apoptosis, Gallus gallus"
is_a: GO:0043067 ! regulation of programmed cell death
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006915 ! apoptotic process
relationship: regulates GO:0006915 ! apoptotic process

[Term]
id: GO:0042982
name: amyloid precursor protein metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving amyloid precursor protein (APP), the precursor of beta-amyloid, a glycoprotein associated with Alzheimer's disease." [GOC:go_curators]
subset: gosubset_prok
synonym: "amyloid precursor protein metabolism" EXACT []
synonym: "APP metabolic process" EXACT []
synonym: "APP metabolism" EXACT []
is_a: GO:0019538 ! protein metabolic process

[Term]
id: GO:0042983
name: amyloid precursor protein biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid, a glycoprotein associated with Alzheimer's disease." [GOC:go_curators]
subset: gosubset_prok
synonym: "amyloid precursor protein anabolism" EXACT []
synonym: "amyloid precursor protein biosynthesis" EXACT []
synonym: "amyloid precursor protein formation" EXACT []
synonym: "amyloid precursor protein synthesis" EXACT []
synonym: "APP biosynthesis" EXACT []
synonym: "APP biosynthetic process" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0042982 ! amyloid precursor protein metabolic process

[Term]
id: GO:0042984
name: regulation of amyloid precursor protein biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of amyloid precursor protein anabolism" EXACT []
synonym: "regulation of amyloid precursor protein biosynthesis" EXACT []
synonym: "regulation of amyloid precursor protein formation" EXACT []
synonym: "regulation of amyloid precursor protein synthesis" EXACT []
synonym: "regulation of APP biosynthesis" EXACT []
synonym: "regulation of APP biosynthetic process" EXACT []
is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042983 ! amyloid precursor protein biosynthetic process
relationship: regulates GO:0042983 ! amyloid precursor protein biosynthetic process

[Term]
id: GO:0042985
name: negative regulation of amyloid precursor protein biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of amyloid precursor protein biosynthetic process" EXACT []
synonym: "down-regulation of amyloid precursor protein biosynthetic process" EXACT []
synonym: "downregulation of amyloid precursor protein biosynthetic process" EXACT []
synonym: "inhibition of amyloid precursor protein biosynthetic process" NARROW []
synonym: "negative regulation of amyloid precursor protein anabolism" EXACT []
synonym: "negative regulation of amyloid precursor protein biosynthesis" EXACT []
synonym: "negative regulation of amyloid precursor protein formation" EXACT []
synonym: "negative regulation of amyloid precursor protein synthesis" EXACT []
synonym: "negative regulation of APP biosynthesis" EXACT []
synonym: "negative regulation of APP biosynthetic process" EXACT []
is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process
is_a: GO:0042984 ! regulation of amyloid precursor protein biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042983 ! amyloid precursor protein biosynthetic process
relationship: negatively_regulates GO:0042983 ! amyloid precursor protein biosynthetic process

[Term]
id: GO:0042986
name: positive regulation of amyloid precursor protein biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of amyloid precursor protein biosynthetic process" NARROW []
synonym: "positive regulation of amyloid precursor protein anabolism" EXACT []
synonym: "positive regulation of amyloid precursor protein biosynthesis" EXACT []
synonym: "positive regulation of amyloid precursor protein formation" EXACT []
synonym: "positive regulation of amyloid precursor protein synthesis" EXACT []
synonym: "positive regulation of APP biosynthesis" EXACT []
synonym: "positive regulation of APP biosynthetic process" EXACT []
synonym: "stimulation of amyloid precursor protein biosynthetic process" NARROW []
synonym: "up regulation of amyloid precursor protein biosynthetic process" EXACT []
synonym: "up-regulation of amyloid precursor protein biosynthetic process" EXACT []
synonym: "upregulation of amyloid precursor protein biosynthetic process" EXACT []
is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process
is_a: GO:0042984 ! regulation of amyloid precursor protein biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042983 ! amyloid precursor protein biosynthetic process
relationship: positively_regulates GO:0042983 ! amyloid precursor protein biosynthetic process

[Term]
id: GO:0042987
name: amyloid precursor protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of amyloid precursor protein (APP), the precursor of beta-amyloid, a glycoprotein associated with Alzheimer's disease." [GOC:go_curators]
synonym: "amyloid precursor protein breakdown" EXACT []
synonym: "amyloid precursor protein catabolism" EXACT []
synonym: "amyloid precursor protein degradation" EXACT []
synonym: "APP catabolic process" EXACT []
synonym: "APP catabolism" EXACT []
is_a: GO:0042982 ! amyloid precursor protein metabolic process

[Term]
id: GO:0042988
name: X11-like protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with X11-like protein, a neuron-specific adaptor protein." [GOC:jl, PMID:12780348]
synonym: "X11L binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0042989
name: sequestering of actin monomers
namespace: biological_process
def: "The selective interaction of actin monomers with specific molecules that inhibit their polymerization by preventing their access to other monomers." [GOC:go_curators]
synonym: "actin monomer retention" EXACT []
synonym: "actin monomer sequestering" EXACT []
synonym: "actin monomer sequestering activity" RELATED []
synonym: "actin monomer sequestration" EXACT []
synonym: "actin monomer storage" EXACT []
synonym: "retention of actin monomers" EXACT []
synonym: "sequestration of actin monomers" EXACT []
synonym: "storage of actin monomers" EXACT []
is_a: GO:0030837 ! negative regulation of actin filament polymerization
is_a: GO:0032507 ! maintenance of protein location in cell

[Term]
id: GO:0042990
name: regulation of transcription factor import into nucleus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus." [GOC:jl]
synonym: "regulation of transcription factor import into cell nucleus" EXACT []
synonym: "regulation of transcription factor transport from cytoplasm to nucleus" EXACT []
synonym: "regulation of transcription factor-nucleus import" EXACT []
is_a: GO:0042306 ! regulation of protein import into nucleus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042991 ! transcription factor import into nucleus
relationship: regulates GO:0042991 ! transcription factor import into nucleus

[Term]
id: GO:0042991
name: transcription factor import into nucleus
namespace: biological_process
def: "The directed movement of a transcription factor from the cytoplasm to the nucleus." [GOC:jl]
synonym: "transcription factor import into cell nucleus" EXACT []
synonym: "transcription factor transport from cytoplasm to nucleus" EXACT []
synonym: "transcription factor-nucleus import" EXACT []
is_a: GO:0006606 ! protein import into nucleus

[Term]
id: GO:0042992
name: negative regulation of transcription factor import into nucleus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus." [GOC:jl]
synonym: "down regulation of transcription factor import into nucleus" EXACT []
synonym: "down-regulation of transcription factor import into nucleus" EXACT []
synonym: "downregulation of transcription factor import into nucleus" EXACT []
synonym: "inhibition of transcription factor import into nucleus" NARROW []
synonym: "negative regulation of transcription factor import into cell nucleus" EXACT []
synonym: "negative regulation of transcription factor transport from cytoplasm to nucleus" EXACT []
synonym: "negative regulation of transcription factor-nucleus import" EXACT []
is_a: GO:0042308 ! negative regulation of protein import into nucleus
is_a: GO:0042990 ! regulation of transcription factor import into nucleus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042991 ! transcription factor import into nucleus
relationship: negatively_regulates GO:0042991 ! transcription factor import into nucleus

[Term]
id: GO:0042993
name: positive regulation of transcription factor import into nucleus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus." [GOC:jl]
synonym: "activation of transcription factor import into nucleus" NARROW []
synonym: "positive regulation of transcription factor import into cell nucleus" EXACT []
synonym: "positive regulation of transcription factor transport from cytoplasm to nucleus" EXACT []
synonym: "positive regulation of transcription factor-nucleus import" EXACT []
synonym: "stimulation of transcription factor import into nucleus" NARROW []
synonym: "up regulation of transcription factor import into nucleus" EXACT []
synonym: "up-regulation of transcription factor import into nucleus" EXACT []
synonym: "upregulation of transcription factor import into nucleus" EXACT []
is_a: GO:0042307 ! positive regulation of protein import into nucleus
is_a: GO:0042990 ! regulation of transcription factor import into nucleus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042991 ! transcription factor import into nucleus
relationship: positively_regulates GO:0042991 ! transcription factor import into nucleus

[Term]
id: GO:0042994
name: cytoplasmic sequestering of transcription factor
namespace: biological_process
def: "The selective interaction of a transcription factor with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus." [GOC:jl]
synonym: "cytoplasmic retention of transcription factor" EXACT []
synonym: "cytoplasmic sequestration of transcription factor" EXACT []
synonym: "cytoplasmic storage of transcription factor" EXACT []
synonym: "maintenance of transcription factor protein location in cytoplasm" EXACT [GOC:dph, GOC:tb]
synonym: "retention of transcription factor in cytoplasm" EXACT []
synonym: "sequestering of transcription factor in cytoplasm" EXACT []
synonym: "sequestration of transcription factor in cytoplasm" EXACT []
synonym: "storage of transcription factor in cytoplasm" EXACT []
synonym: "transcription factor binding, cytoplasmic sequestering" EXACT []
is_a: GO:0042992 ! negative regulation of transcription factor import into nucleus
is_a: GO:0051220 ! cytoplasmic sequestering of protein

[Term]
id: GO:0042995
name: cell projection
namespace: cellular_component
def: "A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]
subset: goslim_pir
subset: gosubset_prok
synonym: "cell process" BROAD []
synonym: "cellular process" BROAD []
synonym: "cellular projection" EXACT []
is_a: GO:0044464 ! cell part
relationship: has_part GO:0098590 ! plasma membrane region

[Term]
id: GO:0042996
name: regulation of Golgi to plasma membrane protein transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane." [GOC:jl]
is_a: GO:0033157 ! regulation of intracellular protein transport
is_a: GO:0060627 ! regulation of vesicle-mediated transport
is_a: GO:0090003 ! regulation of establishment of protein localization to plasma membrane
is_a: GO:1903649 ! regulation of cytoplasmic transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043001 ! Golgi to plasma membrane protein transport
relationship: regulates GO:0043001 ! Golgi to plasma membrane protein transport

[Term]
id: GO:0042997
name: negative regulation of Golgi to plasma membrane protein transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane." [GOC:jl]
synonym: "down regulation of Golgi to plasma membrane protein transport" EXACT []
synonym: "down-regulation of Golgi to plasma membrane protein transport" EXACT []
synonym: "downregulation of Golgi to plasma membrane protein transport" EXACT []
synonym: "inhibition of Golgi to plasma membrane protein transport" NARROW []
is_a: GO:0042996 ! regulation of Golgi to plasma membrane protein transport
is_a: GO:0090005 ! negative regulation of establishment of protein localization to plasma membrane
is_a: GO:0090317 ! negative regulation of intracellular protein transport
is_a: GO:1903650 ! negative regulation of cytoplasmic transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043001 ! Golgi to plasma membrane protein transport
relationship: negatively_regulates GO:0043001 ! Golgi to plasma membrane protein transport

[Term]
id: GO:0042998
name: positive regulation of Golgi to plasma membrane protein transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane." [GOC:jl]
synonym: "activation of Golgi to plasma membrane protein transport" NARROW []
synonym: "stimulation of Golgi to plasma membrane protein transport" NARROW []
synonym: "up regulation of Golgi to plasma membrane protein transport" EXACT []
synonym: "up-regulation of Golgi to plasma membrane protein transport" EXACT []
synonym: "upregulation of Golgi to plasma membrane protein transport" EXACT []
is_a: GO:0042996 ! regulation of Golgi to plasma membrane protein transport
is_a: GO:0090004 ! positive regulation of establishment of protein localization to plasma membrane
is_a: GO:0090316 ! positive regulation of intracellular protein transport
is_a: GO:1903651 ! positive regulation of cytoplasmic transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043001 ! Golgi to plasma membrane protein transport
relationship: positively_regulates GO:0043001 ! Golgi to plasma membrane protein transport

[Term]
id: GO:0042999
name: regulation of Golgi to plasma membrane CFTR protein transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transport of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane." [GOC:jl]
is_a: GO:0042996 ! regulation of Golgi to plasma membrane protein transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043000 ! Golgi to plasma membrane CFTR protein transport
relationship: regulates GO:0043000 ! Golgi to plasma membrane CFTR protein transport

[Term]
id: GO:0043000
name: Golgi to plasma membrane CFTR protein transport
namespace: biological_process
def: "The directed movement of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane." [GOC:jl]
synonym: "Golgi to plasma membrane cystic fibrosis transmembrane conductance regulator protein transport" EXACT []
is_a: GO:0043001 ! Golgi to plasma membrane protein transport

[Term]
id: GO:0043001
name: Golgi to plasma membrane protein transport
namespace: biological_process
def: "The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane." [ISBN:0716731363]
is_a: GO:0006886 ! intracellular protein transport
is_a: GO:0006893 ! Golgi to plasma membrane transport
is_a: GO:0072659 ! protein localization to plasma membrane
is_a: GO:0090002 ! establishment of protein localization to plasma membrane

[Term]
id: GO:0043002
name: negative regulation of Golgi to plasma membrane CFTR protein transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transport of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane." [GOC:jl]
synonym: "down regulation of Golgi to plasma membrane CFTR protein transport" EXACT []
synonym: "down-regulation of Golgi to plasma membrane CFTR protein transport" EXACT []
synonym: "downregulation of Golgi to plasma membrane CFTR protein transport" EXACT []
synonym: "inhibition of Golgi to plasma membrane CFTR protein transport" NARROW []
is_a: GO:0042997 ! negative regulation of Golgi to plasma membrane protein transport
is_a: GO:0042999 ! regulation of Golgi to plasma membrane CFTR protein transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043000 ! Golgi to plasma membrane CFTR protein transport
relationship: negatively_regulates GO:0043000 ! Golgi to plasma membrane CFTR protein transport

[Term]
id: GO:0043003
name: positive regulation of Golgi to plasma membrane CFTR protein transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transport of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane." [GOC:jl]
synonym: "activation of Golgi to plasma membrane CFTR protein transport" NARROW []
synonym: "stimulation of Golgi to plasma membrane CFTR protein transport" NARROW []
synonym: "up regulation of Golgi to plasma membrane CFTR protein transport" EXACT []
synonym: "up-regulation of Golgi to plasma membrane CFTR protein transport" EXACT []
synonym: "upregulation of Golgi to plasma membrane CFTR protein transport" EXACT []
is_a: GO:0042998 ! positive regulation of Golgi to plasma membrane protein transport
is_a: GO:0042999 ! regulation of Golgi to plasma membrane CFTR protein transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043000 ! Golgi to plasma membrane CFTR protein transport
relationship: positively_regulates GO:0043000 ! Golgi to plasma membrane CFTR protein transport

[Term]
id: GO:0043004
name: cytoplasmic sequestering of CFTR protein
namespace: biological_process
def: "The selective interaction of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein with specific molecules in the cytoplasm, thereby inhibiting its transport to the cell membrane." [GOC:jl]
synonym: "cytoplasmic retention of CFTR (cystic fibrosis transmembrane conductance regulator) protein" EXACT []
synonym: "cytoplasmic sequestering of cystic fibrosis transmembrane conductance regulator protein" EXACT []
synonym: "cytoplasmic sequestration of CFTR (cystic fibrosis transmembrane conductance regulator protein)" EXACT []
synonym: "cytoplasmic storage of CFTR (cystic fibrosis transmembrane conductance regulator) protein" EXACT []
synonym: "maintenance of CFTR protein location in cytoplasm" EXACT [GOC:dph, GOC:tb]
synonym: "retention of CFTR (cystic fibrosis transmembrane conductance regulator) protein in cytoplasm" EXACT []
synonym: "sequestering of CFTR (cystic fibrosis transmembrane conductance regulator protein) in cytoplasm" EXACT []
synonym: "sequestration of CFTR (cystic fibrosis transmembrane conductance regulator protein) in cytoplasm" EXACT []
synonym: "storage of CFTR (cystic fibrosis transmembrane conductance regulator) protein in cytoplasm" EXACT []
is_a: GO:0043002 ! negative regulation of Golgi to plasma membrane CFTR protein transport
is_a: GO:0051220 ! cytoplasmic sequestering of protein

[Term]
id: GO:0043005
name: neuron projection
namespace: cellular_component
def: "A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]
subset: goslim_pir
synonym: "nerve fiber" RELATED [GOC:dph]
synonym: "neurite" NARROW []
synonym: "neuron process" EXACT []
synonym: "neuron protrusion" EXACT [NIF_Subcellular:sao-250931889]
synonym: "neuronal cell projection" EXACT []
xref: NIF_Subcellular:sao-867568886
is_a: GO:0042995 ! cell projection
is_a: GO:0097458 ! neuron part

[Term]
id: GO:0043006
name: activation of phospholipase A2 activity by calcium-mediated signaling
namespace: biological_process
def: "A series of molecular signals that leads to the upregulation of calcium-dependent phospholipase A2 activity in response to the signal." [GOC:dph, GOC:jl, GOC:tb]
synonym: "activation of phospholipase A2 activity by calcium-mediated signalling" EXACT [GOC:mah]
synonym: "calcium-dependent activation of phospholipase A2" EXACT [GOC:dph, GOC:tb]
synonym: "calcium-dependent phospholipase A2 activation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0019722 ! calcium-mediated signaling
is_a: GO:0032431 ! activation of phospholipase A2 activity

[Term]
id: GO:0043007
name: maintenance of rDNA
namespace: biological_process
def: "Any process involved in sustaining the fidelity and copy number of rDNA repeats." [GOC:vw, PMID:14528010]
synonym: "rDNA maintenance" EXACT []
synonym: "ribosomal DNA maintenance" EXACT []
is_a: GO:0043570 ! maintenance of DNA repeat elements

[Term]
id: GO:0043008
name: ATP-dependent protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) using energy from the hydrolysis of ATP." [GOC:jl]
subset: goslim_chembl
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0043009
name: chordate embryonic development
namespace: biological_process
def: "The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching." [GOC:mtg_sensu]
is_a: GO:0009792 ! embryo development ending in birth or egg hatching

[Term]
id: GO:0043010
name: camera-type eye development
namespace: biological_process
alt_id: GO:0001747
alt_id: GO:0031075
def: "The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field." [GOC:go_curators, GOC:mtg_sensu]
is_a: GO:0001654 ! eye development

[Term]
id: GO:0043011
name: myeloid dendritic cell differentiation
namespace: biological_process
def: "The process in which a monocyte acquires the specialized features of a dendritic cell, an immunocompetent cell of the lymphoid and hemopoietic systems and skin." [CL:0000782, GOC:jl]
xref: Wikipedia:Dendritic_cell
is_a: GO:0001773 ! myeloid dendritic cell activation
is_a: GO:0002573 ! myeloid leukocyte differentiation
is_a: GO:0097028 ! dendritic cell differentiation

[Term]
id: GO:0043012
name: regulation of fusion of sperm to egg plasma membrane
namespace: biological_process
def: "Any process that modulates the binding and fusion of a sperm to the oocyte plasma membrane." [GOC:jl, http://arbl.cvmbs.colostate.edu/hbooks/pathphys/reprod/fert/fert.html]
synonym: "regulation of sperm-oocyte fusion" NARROW []
is_a: GO:0043900 ! regulation of multi-organism process
is_a: GO:0051128 ! regulation of cellular component organization
is_a: GO:0051239 ! regulation of multicellular organismal process
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007342 ! fusion of sperm to egg plasma membrane
relationship: regulates GO:0007342 ! fusion of sperm to egg plasma membrane

[Term]
id: GO:0043013
name: negative regulation of fusion of sperm to egg plasma membrane
namespace: biological_process
def: "Any process that stops or prevents the binding and fusion of a sperm to the oocyte plasma membrane." [GOC:jl, http://arbl.cvmbs.colostate.edu/hbooks/pathphys/reprod/fert/fert.html]
synonym: "down regulation of fusion of sperm to egg plasma membrane" EXACT []
synonym: "down-regulation of fusion of sperm to egg plasma membrane" EXACT []
synonym: "downregulation of fusion of sperm to egg plasma membrane" EXACT []
synonym: "inhibition of fusion of sperm to egg plasma membrane" NARROW []
synonym: "inhibition of sperm-oocyte fusion" NARROW []
synonym: "negative regulation of sperm-oocyte fusion" NARROW []
is_a: GO:0043012 ! regulation of fusion of sperm to egg plasma membrane
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0060467 ! negative regulation of fertilization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007342 ! fusion of sperm to egg plasma membrane
relationship: negatively_regulates GO:0007342 ! fusion of sperm to egg plasma membrane

[Term]
id: GO:0043014
name: alpha-tubulin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the microtubule constituent protein alpha-tubulin." [GOC:jl]
synonym: "alpha tubulin binding" EXACT []
is_a: GO:0015631 ! tubulin binding

[Term]
id: GO:0043015
name: gamma-tubulin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the microtubule constituent protein gamma-tubulin." [GOC:jl]
synonym: "gamma tubulin binding" EXACT []
is_a: GO:0015631 ! tubulin binding

[Term]
id: GO:0043016
name: regulation of lymphotoxin A biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the cytokine lymphotoxin A." [GOC:jl]
synonym: "regulation of LTA biosynthesis" EXACT []
synonym: "regulation of LTA biosynthetic process" EXACT []
synonym: "regulation of lymphotoxin A anabolism" EXACT []
synonym: "regulation of lymphotoxin A biosynthesis" EXACT []
synonym: "regulation of lymphotoxin A formation" EXACT []
synonym: "regulation of lymphotoxin A synthesis" EXACT []
synonym: "regulation of lymphotoxin-alpha biosynthesis" EXACT []
synonym: "regulation of lymphotoxin-alpha biosynthetic process" EXACT []
synonym: "regulation of TNF-B biosynthesis" EXACT []
synonym: "regulation of TNF-B biosynthetic process" EXACT []
synonym: "regulation of TNF-beta biosynthesis" EXACT []
synonym: "regulation of TNF-beta biosynthetic process" EXACT []
synonym: "regulation of tumor necrosis factor-beta biosynthesis" EXACT []
synonym: "regulation of tumor necrosis factor-beta biosynthetic process" EXACT []
is_a: GO:0032681 ! regulation of lymphotoxin A production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042109 ! lymphotoxin A biosynthetic process
relationship: regulates GO:0042109 ! lymphotoxin A biosynthetic process

[Term]
id: GO:0043017
name: positive regulation of lymphotoxin A biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the cytokine lymphotoxin A." [GOC:jl]
synonym: "activation of lymphotoxin A biosynthetic process" NARROW []
synonym: "positive regulation of LTA biosynthesis" EXACT []
synonym: "positive regulation of LTA biosynthetic process" EXACT []
synonym: "positive regulation of lymphotoxin A anabolism" EXACT []
synonym: "positive regulation of lymphotoxin A biosynthesis" EXACT []
synonym: "positive regulation of lymphotoxin A formation" EXACT []
synonym: "positive regulation of lymphotoxin A synthesis" EXACT []
synonym: "positive regulation of lymphotoxin-alpha biosynthesis" EXACT []
synonym: "positive regulation of lymphotoxin-alpha biosynthetic process" EXACT []
synonym: "positive regulation of TNF-B biosynthesis" EXACT []
synonym: "positive regulation of TNF-B biosynthetic process" EXACT []
synonym: "positive regulation of TNF-beta biosynthesis" EXACT []
synonym: "positive regulation of TNF-beta biosynthetic process" EXACT []
synonym: "positive regulation of tumor necrosis factor-beta biosynthesis" EXACT []
synonym: "positive regulation of tumor necrosis factor-beta biosynthetic process" EXACT []
synonym: "stimulation of lymphotoxin A biosynthetic process" NARROW []
synonym: "up regulation of lymphotoxin A biosynthetic process" EXACT []
synonym: "up-regulation of lymphotoxin A biosynthetic process" EXACT []
synonym: "upregulation of lymphotoxin A biosynthetic process" EXACT []
is_a: GO:0032761 ! positive regulation of lymphotoxin A production
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0043016 ! regulation of lymphotoxin A biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042109 ! lymphotoxin A biosynthetic process
relationship: positively_regulates GO:0042109 ! lymphotoxin A biosynthetic process

[Term]
id: GO:0043018
name: negative regulation of lymphotoxin A biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the cytokine lymphotoxin A." [GOC:jl]
synonym: "down regulation of lymphotoxin A biosynthetic process" EXACT []
synonym: "down-regulation of lymphotoxin A biosynthetic process" EXACT []
synonym: "downregulation of lymphotoxin A biosynthetic process" EXACT []
synonym: "inhibition of lymphotoxin A biosynthetic process" NARROW []
synonym: "negative regulation of LTA biosynthesis" EXACT []
synonym: "negative regulation of LTA biosynthetic process" EXACT []
synonym: "negative regulation of lymphotoxin A anabolism" EXACT []
synonym: "negative regulation of lymphotoxin A biosynthesis" EXACT []
synonym: "negative regulation of lymphotoxin A formation" EXACT []
synonym: "negative regulation of lymphotoxin A synthesis" EXACT []
synonym: "negative regulation of lymphotoxin-alpha biosynthesis" EXACT []
synonym: "negative regulation of lymphotoxin-alpha biosynthetic process" EXACT []
synonym: "negative regulation of TNF-B biosynthesis" EXACT []
synonym: "negative regulation of TNF-B biosynthetic process" EXACT []
synonym: "negative regulation of TNF-beta biosynthesis" EXACT []
synonym: "negative regulation of TNF-beta biosynthetic process" EXACT []
synonym: "negative regulation of tumor necrosis factor-beta biosynthesis" EXACT []
synonym: "negative regulation of tumor necrosis factor-beta biosynthetic process" EXACT []
is_a: GO:0032721 ! negative regulation of lymphotoxin A production
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0043016 ! regulation of lymphotoxin A biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042109 ! lymphotoxin A biosynthetic process
relationship: negatively_regulates GO:0042109 ! lymphotoxin A biosynthetic process

[Term]
id: GO:0043020
name: NADPH oxidase complex
namespace: cellular_component
def: "A enzyme complex of which the core is a heterodimer composed of a light (alpha) and heavy (beta) chain, and requires several other water-soluble proteins of cytosolic origin for activity. Functions in superoxide generation by the NADPH-dependent reduction of O2." [GOC:jl, PMID:11483596, PMID:12440767]
synonym: "flavocytochrome b558" NARROW []
synonym: "respiratory-burst oxidase" RELATED []
is_a: GO:0098797 ! plasma membrane protein complex
is_a: GO:1990204 ! oxidoreductase complex
relationship: part_of GO:0005887 ! integral component of plasma membrane

[Term]
id: GO:0043021
name: ribonucleoprotein complex binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any complex of RNA and protein." [GOC:bf, GOC:go_curators, GOC:vk]
subset: goslim_pir
subset: gosubset_prok
synonym: "protein-RNA complex binding" EXACT [GOC:bf, GOC:vk]
synonym: "ribonucleoprotein binding" EXACT [GOC:bf, GOC:vk]
synonym: "RNP binding" EXACT []
is_a: GO:0044877 ! macromolecular complex binding

[Term]
id: GO:0043022
name: ribosome binding
namespace: molecular_function
alt_id: GO:0030376
def: "Interacting selectively and non-covalently with any part of a ribosome." [GOC:go_curators]
subset: gosubset_prok
synonym: "ribosome receptor activity" NARROW []
is_a: GO:0043021 ! ribonucleoprotein complex binding

[Term]
id: GO:0043023
name: ribosomal large subunit binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any part of the larger ribosomal subunit." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0043021 ! ribonucleoprotein complex binding

[Term]
id: GO:0043024
name: ribosomal small subunit binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any part of the small ribosomal subunit." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0043021 ! ribonucleoprotein complex binding

[Term]
id: GO:0043025
name: neuronal cell body
namespace: cellular_component
def: "The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]
comment: Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections.
subset: goslim_pir
synonym: "neuron cell body" EXACT []
synonym: "neuronal cell soma" EXACT []
xref: NIF_Subcellular:sao1044911821
xref: Wikipedia:Soma_(biology)
is_a: GO:0044297 ! cell body
is_a: GO:0097458 ! neuron part
relationship: part_of GO:0036477 ! somatodendritic compartment

[Term]
id: GO:0043027
name: cysteine-type endopeptidase inhibitor activity involved in apoptotic process
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process." [GOC:jl, GOC:mtg_apoptosis, PMID:14744432, Wikipedia:Caspase]
synonym: "caspase inhibitor activity" BROAD []
is_a: GO:0004869 ! cysteine-type endopeptidase inhibitor activity
is_a: GO:0043028 ! cysteine-type endopeptidase regulator activity involved in apoptotic process
intersection_of: GO:0004869 ! cysteine-type endopeptidase inhibitor activity
intersection_of: part_of GO:0006915 ! apoptotic process
relationship: part_of GO:0006915 ! apoptotic process
relationship: part_of GO:0043154 ! negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

[Term]
id: GO:0043028
name: cysteine-type endopeptidase regulator activity involved in apoptotic process
namespace: molecular_function
def: "Modulates the activity of a cysteine-type endopeptidase involved in the apoptotic process." [GOC:jl, GOC:mtg_apoptosis, PMID:14744432, Wikipedia:Caspase]
synonym: "caspase regulator activity" BROAD []
xref: Reactome:REACT_102937 "p75NTR:NADE promotes caspase2/3 activation, Rattus norvegicus"
xref: Reactome:REACT_103522 "p75NTR:NADE promotes caspase2/3 activation, Mus musculus"
xref: Reactome:REACT_108417 "p75NTR:NADE promotes caspase2/3 activation, Canis familiaris"
xref: Reactome:REACT_13533 "p75NTR:NADE promotes caspase2/3 activation, Homo sapiens"
xref: Reactome:REACT_32934 "p75NTR:NADE promotes caspase2/3 activation, Sus scrofa"
xref: Reactome:REACT_89561 "p75NTR:NADE promotes caspase2/3 activation, Bos taurus"
is_a: GO:0030234 ! enzyme regulator activity
relationship: part_of GO:0043281 ! regulation of cysteine-type endopeptidase activity involved in apoptotic process

[Term]
id: GO:0043029
name: T cell homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of T cells such that the total number of T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:mgi_curators, ISBN:0781735149]
comment: Note that this term represents the return of T cell levels to stable numbers following an immune response as well as the proliferation and elimination of T cells required to maintain stable numbers in the absence of an outside stimulus.
synonym: "T lymphocyte homeostasis" EXACT []
synonym: "T-cell homeostasis" EXACT []
synonym: "T-lymphocyte homeostasis" EXACT []
is_a: GO:0002260 ! lymphocyte homeostasis

[Term]
id: GO:0043030
name: regulation of macrophage activation
namespace: biological_process
def: "Any process that modulates the frequency or rate of macrophage activation." [GOC:jl]
is_a: GO:0002694 ! regulation of leukocyte activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042116 ! macrophage activation
relationship: regulates GO:0042116 ! macrophage activation

[Term]
id: GO:0043031
name: negative regulation of macrophage activation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage activation." [GOC:jl]
synonym: "down regulation of macrophage activation" EXACT []
synonym: "down-regulation of macrophage activation" EXACT []
synonym: "downregulation of macrophage activation" EXACT []
synonym: "inhibition of macrophage activation" NARROW []
is_a: GO:0002695 ! negative regulation of leukocyte activation
is_a: GO:0043030 ! regulation of macrophage activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042116 ! macrophage activation
relationship: negatively_regulates GO:0042116 ! macrophage activation

[Term]
id: GO:0043032
name: positive regulation of macrophage activation
namespace: biological_process
def: "Any process that stimulates, induces or increases the rate of macrophage activation." [GOC:jl]
synonym: "activation of macrophage activation" NARROW []
synonym: "stimulation of macrophage activation" NARROW []
synonym: "up regulation of macrophage activation" EXACT []
synonym: "up-regulation of macrophage activation" EXACT []
synonym: "upregulation of macrophage activation" EXACT []
is_a: GO:0002696 ! positive regulation of leukocyte activation
is_a: GO:0043030 ! regulation of macrophage activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042116 ! macrophage activation
relationship: positively_regulates GO:0042116 ! macrophage activation

[Term]
id: GO:0043033
name: isoamylase complex
namespace: cellular_component
def: "A protein complex whose composition varies amongst species; in rice it probably exists in a homo-tetramer to homo-hexamer form and in Gram-negative bacteria as a dimer. Functions in the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages." [GOC:jl, PMID:10333591]
subset: goslim_pir
subset: gosubset_prok
synonym: "debranching enzyme complex" BROAD []
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0043034
name: costamere
namespace: cellular_component
def: "Regular periodic sub membranous arrays of vinculin in skeletal and cardiac muscle cells, these arrays link Z-discs to the sarcolemma and are associated with links to extracellular matrix." [GOC:jl, GOC:mtg_muscle, ISBN:0198506732, PMID:6405378]
xref: Wikipedia:Costamere
is_a: GO:0044449 ! contractile fiber part
relationship: part_of GO:0030016 ! myofibril

[Term]
id: GO:0043035
name: chromatin insulator sequence binding
namespace: molecular_function
def: "Interacting selectively and non-covalently and stoichiometrically with a chromatin insulator sequence, a DNA sequence that prevents enhancer-mediated activation or repression of transcription." [GOC:jl, PMID:12783795]
is_a: GO:0031490 ! chromatin DNA binding

[Term]
id: GO:0043036
name: starch grain
namespace: cellular_component
def: "Plant storage body for amylose and amylopectin, 1-100um in diameter. Also contains small amounts of enzymes, amino acids, lipids and nucleic acids. The shape of the grain varies widely amongst species, but is often spherical or disk-shaped." [GOC:jl, PMID:11217978]
synonym: "starch granule" EXACT []
is_a: GO:0044435 ! plastid part

[Term]
id: GO:0043038
name: amino acid activation
namespace: biological_process
def: "The modification of an amino acid to an active form, for incorporation into a peptide, protein or other macromolecule." [GOC:jl]
subset: gosubset_prok
is_a: GO:0006520 ! cellular amino acid metabolic process

[Term]
id: GO:0043039
name: tRNA aminoacylation
namespace: biological_process
def: "The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules." [GOC:ma, GOC:mah, MetaCyc:Aminoacyl-tRNAs]
subset: gosubset_prok
synonym: "aminoacyl-tRNA biosynthesis" EXACT [GOC:mah]
synonym: "aminoacyl-tRNA biosynthetic process" EXACT [GOC:mah]
synonym: "tRNA charging" EXACT []
is_a: GO:0006399 ! tRNA metabolic process
is_a: GO:0043038 ! amino acid activation

[Term]
id: GO:0043040
name: tRNA aminoacylation for nonribosomal peptide biosynthetic process
namespace: biological_process
def: "The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in nonribosomal peptide synthesis." [GOC:jl]
subset: gosubset_prok
synonym: "tRNA aminoacylation for nonribosomal peptide anabolism" EXACT []
synonym: "tRNA aminoacylation for nonribosomal peptide biosynthesis" EXACT []
synonym: "tRNA aminoacylation for nonribosomal peptide formation" EXACT []
synonym: "tRNA aminoacylation for nonribosomal peptide synthesis" EXACT []
is_a: GO:0043039 ! tRNA aminoacylation
is_a: GO:0043041 ! amino acid activation for nonribosomal peptide biosynthetic process

[Term]
id: GO:0043041
name: amino acid activation for nonribosomal peptide biosynthetic process
namespace: biological_process
def: "Activation of an amino acid for incorporation into a peptide by a nonribosomal process." [GOC:jl]
subset: gosubset_prok
synonym: "nonribosomal amino acid activation" RELATED []
is_a: GO:0043038 ! amino acid activation
relationship: part_of GO:0019184 ! nonribosomal peptide biosynthetic process

[Term]
id: GO:0043042
name: amino acid adenylylation by nonribosomal peptide synthase
namespace: biological_process
def: "Activation of an amino acid for incorporation into a peptide by a nonribosomal process, catalyzed by subunits of nonribosomal peptide synthase. The amino acid is adenylated at its carboxylate group (ATP-dependent) then transferred to the thiol group of an enzyme-bound phosphopantetheine cofactor." [GOC:jl, PMID:9250661, PMID:9712910]
subset: gosubset_prok
synonym: "amino acid adenylation by nonribosomal peptide synthase" EXACT []
synonym: "amino acid adenylation by NRPS" EXACT []
is_a: GO:0043041 ! amino acid activation for nonribosomal peptide biosynthetic process

[Term]
id: GO:0043043
name: peptide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. This may include the translation of a precursor protein and its subsequent processing into a functional peptide." [CHEBI:16670, GOC:dph, GOC:jl]
subset: gosubset_prok
synonym: "peptide anabolism" EXACT []
synonym: "peptide biosynthesis" EXACT []
synonym: "peptide formation" EXACT []
synonym: "peptide synthesis" EXACT []
is_a: GO:0006518 ! peptide metabolic process
is_a: GO:0043604 ! amide biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process

[Term]
id: GO:0043044
name: ATP-dependent chromatin remodeling
namespace: biological_process
def: "Dynamic structural changes to eukaryotic chromatin that require energy from the hydrolysis of ATP, ranging from local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation, mediated by ATP-dependent chromatin-remodelling factors." [GOC:jl, PMID:12042764]
synonym: "ATP-dependent chromatin remodelling" EXACT []
is_a: GO:0006338 ! chromatin remodeling

[Term]
id: GO:0043045
name: DNA methylation involved in embryo development
namespace: biological_process
def: "The covalent transfer of a methyl group to C-5 of cytosine that contributes to the epigenetic regulation of embryonic gene expression." [GOC:go_curators, PMID:12138111]
synonym: "de novo DNA methylation" RELATED []
is_a: GO:0006306 ! DNA methylation
is_a: GO:1901538 ! changes to DNA methylation involved in embryo development
intersection_of: GO:0006306 ! DNA methylation
intersection_of: part_of GO:0009790 ! embryo development
relationship: part_of GO:0009790 ! embryo development

[Term]
id: GO:0043046
name: DNA methylation involved in gamete generation
namespace: biological_process
def: "The covalent transfer of a methyl group to C-5 of cytosine that contributes to the establishment of DNA methylation patterns in the gamete." [GOC:go_curators, PMID:12138111]
synonym: "de novo DNA methylation" RELATED []
is_a: GO:0006306 ! DNA methylation
is_a: GO:0022414 ! reproductive process
intersection_of: GO:0006306 ! DNA methylation
intersection_of: part_of GO:0007276 ! gamete generation
relationship: part_of GO:0007276 ! gamete generation

[Term]
id: GO:0043047
name: single-stranded telomeric DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with single-stranded telomere-associated DNA." [GOC:jl, ISBN:0321000382]
synonym: "telomeric ssDNA binding" EXACT [GOC:mah]
is_a: GO:0042162 ! telomeric DNA binding
is_a: GO:0098847 ! sequence-specific single stranded DNA binding

[Term]
id: GO:0043048
name: dolichyl monophosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dolichyl diphosphate, a phosphorylated dolichol derivative." [GOC:jl]
subset: gosubset_prok
synonym: "dolichyl monophosphate anabolism" EXACT []
synonym: "dolichyl monophosphate biosynthesis" EXACT []
synonym: "dolichyl monophosphate formation" EXACT []
synonym: "dolichyl monophosphate synthesis" EXACT []
is_a: GO:0008654 ! phospholipid biosynthetic process

[Term]
id: GO:0043049
name: otic placode formation
namespace: biological_process
def: "The initial developmental process that will lead to the formation of the vertebrate inner ear. The otic placode forms as a thickening of the head ectoderm adjacent to the developing hindbrain." [GOC:go_curators, PMID:12668634]
is_a: GO:0060788 ! ectodermal placode formation
relationship: part_of GO:0030916 ! otic vesicle formation

[Term]
id: GO:0043050
name: pharyngeal pumping
namespace: biological_process
def: "The contraction and relaxation movements of the pharyngeal muscle that mediate feeding in nematodes." [GOC:cab1, PMID:2181052]
synonym: "pumping behavior" RELATED []
is_a: GO:0042755 ! eating behavior

[Term]
id: GO:0043051
name: regulation of pharyngeal pumping
namespace: biological_process
def: "Any process that modulates the contraction and relaxation movements of the pharyngeal muscle that mediates feeding in nematodes." [GOC:cab1, PMID:2181052]
is_a: GO:1903998 ! regulation of eating behavior
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043050 ! pharyngeal pumping
relationship: regulates GO:0043050 ! pharyngeal pumping

[Term]
id: GO:0043052
name: thermotaxis
namespace: biological_process
def: "The directed movement of a motile cell or organism in response to a temperature gradient. Movement may be towards either a higher or lower temperature." [GOC:cab1, WB_REF:cgc467]
synonym: "taxis in response to temperature stimulus" EXACT []
xref: Wikipedia:Thermotaxis
is_a: GO:0009266 ! response to temperature stimulus
is_a: GO:0042330 ! taxis

[Term]
id: GO:0043053
name: dauer entry
namespace: biological_process
def: "Entry into the facultative diapause of the dauer (enduring) larval stage of nematode development." [GOC:cab1, GOC:kmv, PMID:10077613]
synonym: "nematode entry into dormancy" EXACT []
is_a: GO:0055115 ! entry into diapause
relationship: part_of GO:0040024 ! dauer larval development

[Term]
id: GO:0043054
name: dauer exit
namespace: biological_process
def: "Exit from the facultative diapause of the dauer (enduring) larval stage of nematode development." [GOC:cab1, PMID:12620986]
synonym: "exit from nematode dormancy" EXACT []
is_a: GO:0071981 ! exit from diapause
relationship: part_of GO:0040024 ! dauer larval development

[Term]
id: GO:0043055
name: maintenance of dauer
namespace: biological_process
def: "Maintenance of a nematode during the facultative diapause of the dauer (enduring) larval stage of nematode development." [GOC:cab1, WB_REF:wm2003ab740]
synonym: "maintenance of dormancy in the nematode" EXACT []
is_a: GO:0071982 ! maintenance of diapause
relationship: part_of GO:0040024 ! dauer larval development

[Term]
id: GO:0043056
name: forward locomotion
namespace: biological_process
def: "Anterior movement of an organism, following the direction of the head of the animal." [GOC:go_curators]
is_a: GO:0033058 ! directional locomotion

[Term]
id: GO:0043057
name: backward locomotion
namespace: biological_process
def: "Posterior movement of an organism, e.g. following the direction of the tail of an animal." [GOC:go_curators]
is_a: GO:0033058 ! directional locomotion

[Term]
id: GO:0043058
name: regulation of backward locomotion
namespace: biological_process
def: "Any process that modulates the speed, mechanical force, or rhythm of the posterior movement of an organism." [GOC:go_curators]
is_a: GO:0040012 ! regulation of locomotion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043057 ! backward locomotion
relationship: regulates GO:0043057 ! backward locomotion

[Term]
id: GO:0043059
name: regulation of forward locomotion
namespace: biological_process
def: "Any process that modulates the speed, mechanical force, or rhythm of the anterior movement of an organism." [GOC:go_curators]
is_a: GO:0040012 ! regulation of locomotion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043056 ! forward locomotion
relationship: regulates GO:0043056 ! forward locomotion

[Term]
id: GO:0043060
name: meiotic metaphase I plate congression
namespace: biological_process
def: "The alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the meiotic spindle, during meiosis I." [GOC:cab1, PMID:10809666]
is_a: GO:0051311 ! meiotic metaphase plate congression
relationship: part_of GO:0045143 ! homologous chromosome segregation

[Term]
id: GO:0043061
name: meiotic metaphase II plate congression
namespace: biological_process
def: "The alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the meiotic spindle, during meiosis II." [GOC:cab1, PMID:10809666]
is_a: GO:0051311 ! meiotic metaphase plate congression
relationship: part_of GO:0045144 ! meiotic sister chromatid segregation

[Term]
id: GO:0043062
name: extracellular structure organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
subset: goslim_pir
subset: gosubset_prok
synonym: "extracellular structure organisation" EXACT [GOC:curators]
synonym: "extracellular structure organization and biogenesis" EXACT [GOC:dph, GOC:jl, GOC:mah]
is_a: GO:0016043 ! cellular component organization
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0043063
name: intercellular bridge organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the intracellular bridge. An intracellular bridge is a direct link between the cytoplasms of sister cells that allows cells to communicate with one another." [GOC:jid]
synonym: "intercellular bridge organisation" EXACT [GOC:curators]
synonym: "intercellular bridge organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0043062 ! extracellular structure organization

[Term]
id: GO:0043064
name: obsolete flagellum organization
namespace: biological_process
def: "OBSOLETE. A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a flagellum, a long thin projection from a cell, used in movement." [GOC:curators, ISBN:0815316194]
comment: This term was made obsolete because microtubule-based flagellum (GO:0009434) and motile cilium (GO:0031514), as referenced by this term, were determined to be equivalent and merged. When a merge for this term was considered, it was noticed that both eukaryotic and prokaryotic proteins are annotated to it because its meaning had been ambiguous so obsoletion was considered safest.
subset: gosubset_prok
synonym: "flagellum organisation" EXACT [GOC:curators]
synonym: "flagellum organization" EXACT []
synonym: "flagellum organization and biogenesis" RELATED [GOC:mah]
is_obsolete: true
consider: GO:0044781
consider: GO:0044782

[Term]
id: GO:0043065
name: positive regulation of apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
comment: This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is positively regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used.
subset: goslim_chembl
synonym: "activation of apoptosis" NARROW []
synonym: "positive regulation of apoptosis" NARROW []
synonym: "pro-apoptosis" RELATED []
synonym: "stimulation of apoptosis" NARROW []
synonym: "up regulation of apoptosis" EXACT []
synonym: "up-regulation of apoptosis" EXACT []
synonym: "upregulation of apoptosis" EXACT []
is_a: GO:0042981 ! regulation of apoptotic process
is_a: GO:0043068 ! positive regulation of programmed cell death
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006915 ! apoptotic process
relationship: positively_regulates GO:0006915 ! apoptotic process

[Term]
id: GO:0043066
name: negative regulation of apoptotic process
namespace: biological_process
alt_id: GO:0006916
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
comment: This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is negatively regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used.
synonym: "anti-apoptosis" EXACT []
synonym: "apoptosis inhibitor activity" RELATED []
synonym: "down regulation of apoptosis" EXACT []
synonym: "down-regulation of apoptosis" EXACT []
synonym: "downregulation of apoptosis" EXACT []
synonym: "inhibition of apoptosis" NARROW []
synonym: "negative regulation of apoptosis" NARROW []
synonym: "pro-survival" RELATED []
xref: Reactome:REACT_13537 "p75NTR signals via NF-kB, Homo sapiens"
xref: Reactome:REACT_29981 "p75NTR signals via NF-kB, Canis familiaris"
xref: Reactome:REACT_77563 "p75NTR signals via NF-kB, Sus scrofa"
xref: Reactome:REACT_81263 "p75NTR signals via NF-kB, Taeniopygia guttata"
xref: Reactome:REACT_83278 "p75NTR signals via NF-kB, Drosophila melanogaster"
xref: Reactome:REACT_84567 "p75NTR signals via NF-kB, Gallus gallus"
xref: Reactome:REACT_91585 "p75NTR signals via NF-kB, Danio rerio"
xref: Reactome:REACT_93662 "p75NTR signals via NF-kB, Rattus norvegicus"
xref: Reactome:REACT_95215 "p75NTR signals via NF-kB, Mus musculus"
xref: Reactome:REACT_95867 "p75NTR signals via NF-kB, Xenopus tropicalis"
xref: Reactome:REACT_98500 "p75NTR signals via NF-kB, Bos taurus"
is_a: GO:0042981 ! regulation of apoptotic process
is_a: GO:0043069 ! negative regulation of programmed cell death
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006915 ! apoptotic process
relationship: negatively_regulates GO:0006915 ! apoptotic process

[Term]
id: GO:0043067
name: regulation of programmed cell death
namespace: biological_process
alt_id: GO:0043070
def: "Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl]
synonym: "regulation of non-apoptotic programmed cell death" NARROW []
is_a: GO:0010941 ! regulation of cell death
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0012501 ! programmed cell death
relationship: regulates GO:0012501 ! programmed cell death

[Term]
id: GO:0043068
name: positive regulation of programmed cell death
namespace: biological_process
alt_id: GO:0043071
def: "Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl]
synonym: "activation of programmed cell death" NARROW []
synonym: "positive regulation of non-apoptotic programmed cell death" NARROW []
synonym: "stimulation of programmed cell death" NARROW []
synonym: "up regulation of programmed cell death" EXACT []
synonym: "up-regulation of programmed cell death" EXACT []
synonym: "upregulation of programmed cell death" EXACT []
is_a: GO:0010942 ! positive regulation of cell death
is_a: GO:0043067 ! regulation of programmed cell death
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0012501 ! programmed cell death
relationship: positively_regulates GO:0012501 ! programmed cell death

[Term]
id: GO:0043069
name: negative regulation of programmed cell death
namespace: biological_process
alt_id: GO:0043072
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl]
synonym: "down regulation of programmed cell death" EXACT []
synonym: "down-regulation of programmed cell death" EXACT []
synonym: "downregulation of programmed cell death" EXACT []
synonym: "inhibition of programmed cell death" NARROW []
synonym: "negative regulation of non-apoptotic programmed cell death" NARROW []
is_a: GO:0043067 ! regulation of programmed cell death
is_a: GO:0060548 ! negative regulation of cell death
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0012501 ! programmed cell death
relationship: negatively_regulates GO:0012501 ! programmed cell death

[Term]
id: GO:0043073
name: germ cell nucleus
namespace: cellular_component
def: "The nucleus of a germ cell, a reproductive cell in multicellular organisms." [CL:0000586, GOC:go_curators]
synonym: "germ-cell nucleus" EXACT []
is_a: GO:0005634 ! nucleus

[Term]
id: GO:0043075
name: obsolete sperm cell nucleus (sensu Magnoliophyta)
namespace: cellular_component
def: "OBSOLETE. The nucleus of a plant pollen cell, the male gamete, and its descendents." [GOC:jl]
comment: This term was made obsolete because the definition was incorrect.
synonym: "pollen germ cell nucleus" EXACT []
synonym: "pollen germ-cell nucleus" EXACT []
synonym: "sperm cell nucleus (sensu Magnoliophyta)" EXACT []
is_obsolete: true
consider: GO:0048555

[Term]
id: GO:0043076
name: megasporocyte nucleus
namespace: cellular_component
def: "The nucleus of a megasporocyte, a diploid cell that undergoes meiosis to produce four megaspores, and its descendents." [GOC:jl, ISBN:0618254153]
synonym: "megaspore mother cell nucleus" EXACT []
is_a: GO:0005634 ! nucleus

[Term]
id: GO:0043077
name: initiation of acetate catabolic process
namespace: biological_process
def: "The activation of the chemical reactions and pathways resulting in the breakdown of acetate." [GOC:jl]
subset: gosubset_prok
synonym: "initiation of acetate breakdown" EXACT []
synonym: "initiation of acetate catabolism" EXACT []
synonym: "initiation of acetate degradation" EXACT []
is_a: GO:0045754 ! positive regulation of acetate catabolic process

[Term]
id: GO:0043078
name: polar nucleus
namespace: cellular_component
def: "Either of two nuclei located centrally in a flowering plant embryo sac that eventually fuse to form the endosperm nucleus." [ISBN:0618254153]
is_a: GO:0043076 ! megasporocyte nucleus

[Term]
id: GO:0043079
name: antipodal cell nucleus
namespace: cellular_component
def: "The nucleus of an antipodal cell, one of three cells of the embryo sac in angiosperms, found at the chalazal end of the embryo away from the point of entry of the pollen tube, and its descendents." [CL:0000537, GOC:jl]
is_a: GO:0043076 ! megasporocyte nucleus

[Term]
id: GO:0043082
name: megagametophyte egg cell nucleus
namespace: cellular_component
def: "The nucleus of a plant egg cell. This nucleus is found at the micropylar end of the embryo." [GOC:jl, GOC:mtg_sensu]
is_a: GO:0043076 ! megasporocyte nucleus

[Term]
id: GO:0043083
name: synaptic cleft
namespace: cellular_component
def: "The narrow gap that separates the presynaptic and postsynaptic membranes, into which neurotransmitter is released." [GOC:jl, http://synapses.mcg.edu/anatomy/chemical/synapse.stm]
subset: goslim_synapse
xref: NIF_Subcellular:sao243541954
is_a: GO:0005576 ! extracellular region
is_a: GO:0044456 ! synapse part
relationship: part_of GO:0045202 ! synapse

[Term]
id: GO:0043084
name: penile erection
namespace: biological_process
def: "The hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow." [GOC:jl, Wikipedia:Penile_erection]
xref: Wikipedia:Erection#Penile_erection
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0048609 ! multicellular organismal reproductive process
relationship: part_of GO:0007620 ! copulation

[Term]
id: GO:0043085
name: positive regulation of catalytic activity
namespace: biological_process
alt_id: GO:0048554
def: "Any process that activates or increases the activity of an enzyme." [GOC:ebc, GOC:jl, GOC:tb]
subset: goslim_chembl
subset: gosubset_prok
synonym: "activation of enzyme activity" NARROW []
synonym: "activation of metalloenzyme activity" NARROW []
synonym: "positive regulation of enzyme activity" EXACT [GOC:tb]
synonym: "positive regulation of metalloenzyme activity" NARROW []
synonym: "stimulation of enzyme activity" NARROW []
synonym: "stimulation of metalloenzyme activity" NARROW []
synonym: "up regulation of enzyme activity" EXACT []
synonym: "up regulation of metalloenzyme activity" NARROW []
synonym: "up-regulation of enzyme activity" EXACT []
synonym: "up-regulation of metalloenzyme activity" NARROW []
synonym: "upregulation of enzyme activity" EXACT []
synonym: "upregulation of metalloenzyme activity" NARROW []
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0044093 ! positive regulation of molecular function
is_a: GO:0050790 ! regulation of catalytic activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003824 ! catalytic activity
relationship: positively_regulates GO:0003824 ! catalytic activity

[Term]
id: GO:0043086
name: negative regulation of catalytic activity
namespace: biological_process
alt_id: GO:0048553
def: "Any process that stops or reduces the activity of an enzyme." [GOC:ebc, GOC:jl, GOC:tb]
subset: gosubset_prok
synonym: "down regulation of enzyme activity" EXACT []
synonym: "down regulation of metalloenzyme activity" NARROW []
synonym: "down-regulation of enzyme activity" EXACT []
synonym: "down-regulation of metalloenzyme activity" EXACT []
synonym: "downregulation of enzyme activity" EXACT []
synonym: "downregulation of metalloenzyme activity" NARROW []
synonym: "inhibition of enzyme activity" NARROW []
synonym: "inhibition of metalloenzyme activity" NARROW []
synonym: "negative regulation of enzyme activity" EXACT [GOC:tb]
synonym: "negative regulation of metalloenzyme activity" NARROW []
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0044092 ! negative regulation of molecular function
is_a: GO:0050790 ! regulation of catalytic activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003824 ! catalytic activity
relationship: negatively_regulates GO:0003824 ! catalytic activity

[Term]
id: GO:0043087
name: regulation of GTPase activity
namespace: biological_process
alt_id: GO:0032312
alt_id: GO:0032313
alt_id: GO:0032314
alt_id: GO:0032315
alt_id: GO:0032316
alt_id: GO:0032317
alt_id: GO:0032318
alt_id: GO:0032319
alt_id: GO:0043088
def: "Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]
subset: gosubset_prok
synonym: "regulation of ARF GTPase activity" NARROW []
synonym: "regulation of Cdc42 GTPase activity" NARROW []
synonym: "regulation of Rab GTPase activity" NARROW []
synonym: "regulation of Rac GTPase activity" NARROW []
synonym: "regulation of Ral GTPase activity" NARROW []
synonym: "regulation of Ran GTPase activity" NARROW []
synonym: "regulation of Rap GTPase activity" NARROW []
synonym: "regulation of Ras GTPase activity" NARROW []
synonym: "regulation of Rho GTPase activity" NARROW []
is_a: GO:0051336 ! regulation of hydrolase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003924 ! GTPase activity
relationship: regulates GO:0003924 ! GTPase activity

[Term]
id: GO:0043090
name: amino acid import
namespace: biological_process
def: "The directed movement of amino acids into a cell or organelle." [GOC:jl]
subset: gosubset_prok
synonym: "amino acid uptake" EXACT []
is_a: GO:0006865 ! amino acid transport

[Term]
id: GO:0043091
name: L-arginine import
namespace: biological_process
def: "The directed movement of L-arginine, the L-enantiomer of 2-amino-5-guanidinopentanoic acid, into a cell or organelle." [GOC:jl, GOC:jsg, GOC:mah]
synonym: "L-arginine uptake" EXACT []
is_a: GO:0043092 ! L-amino acid import
is_a: GO:0090467 ! arginine import
is_a: GO:1902023 ! L-arginine transport

[Term]
id: GO:0043092
name: L-amino acid import
namespace: biological_process
def: "The directed movement of L-enantiomer amino acids into a cell or organelle." [GOC:jl, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "L-amino acid uptake" EXACT []
is_a: GO:0015807 ! L-amino acid transport
is_a: GO:0043090 ! amino acid import

[Term]
id: GO:0043093
name: FtsZ-dependent cytokinesis
namespace: biological_process
def: "A cytokinesis process that involves a set of conserved proteins including FtsZ, and results in the formation of two similarly sized and shaped cells." [GOC:mah, ISBN:0815108893, PMID:12626683]
comment: Note that this term is intended for the annotation of prokaryotic gene products.
subset: gosubset_prok
synonym: "cytokinesis by binary fission" RELATED [GOC:dph]
synonym: "prokaryote-type cytokinesis" RELATED [GOC:mah]
synonym: "prokaryotic fission" RELATED [Wikipedia:Binary_fission]
xref: Wikipedia:Binary_fission
is_a: GO:0000910 ! cytokinesis
is_a: GO:0044702 ! single organism reproductive process
relationship: part_of GO:0019954 ! asexual reproduction
relationship: part_of GO:0032505 ! reproduction of a single-celled organism

[Term]
id: GO:0043094
name: cellular metabolic compound salvage
namespace: biological_process
def: "Any process which produces a useful metabolic compound from derivatives of it without de novo synthesis, as carried out by individual cells." [GOC:mlg]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0043095
name: regulation of GTP cyclohydrolase I activity
namespace: biological_process
def: "Any process that modulates the activity of the enzyme GTP cyclohydrolase I." [GOC:jl]
subset: gosubset_prok
is_a: GO:0051336 ! regulation of hydrolase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003934 ! GTP cyclohydrolase I activity
relationship: regulates GO:0003934 ! GTP cyclohydrolase I activity

[Term]
id: GO:0043096
name: purine nucleobase salvage
namespace: biological_process
def: "Any process that generates purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from derivatives of them without de novo synthesis." [CHEBI:26386, GOC:jl]
subset: gosubset_prok
synonym: "purine base salvage" EXACT [GOC:go_curators]
is_a: GO:0009113 ! purine nucleobase biosynthetic process
is_a: GO:0043101 ! purine-containing compound salvage

[Term]
id: GO:0043097
name: pyrimidine nucleoside salvage
namespace: biological_process
def: "Any process that generates a pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose, from derivatives of it, without de novo synthesis." [GOC:jl]
subset: gosubset_prok
xref: Reactome:REACT_100088 "Pyrimidine salvage reactions, Caenorhabditis elegans"
xref: Reactome:REACT_101113 "Pyrimidine salvage reactions, Sus scrofa"
xref: Reactome:REACT_102843 "Pyrimidine salvage reactions, Saccharomyces cerevisiae"
xref: Reactome:REACT_105962 "Pyrimidine salvage reactions, Xenopus tropicalis"
xref: Reactome:REACT_109141 "Pyrimidine salvage reactions, Escherichia coli"
xref: Reactome:REACT_109316 "Pyrimidine salvage reactions, Mycobacterium tuberculosis"
xref: Reactome:REACT_110649 "Pyrimidine salvage reactions, Drosophila melanogaster"
xref: Reactome:REACT_29077 "Pyrimidine salvage reactions, Arabidopsis thaliana"
xref: Reactome:REACT_33196 "Pyrimidine salvage reactions, Taeniopygia guttata"
xref: Reactome:REACT_655 "Pyrimidine salvage reactions, Homo sapiens"
xref: Reactome:REACT_78751 "Pyrimidine salvage reactions, Dictyostelium discoideum"
xref: Reactome:REACT_81771 "Pyrimidine salvage reactions, Bos taurus"
xref: Reactome:REACT_85211 "Pyrimidine salvage reactions, Gallus gallus"
xref: Reactome:REACT_85366 "Pyrimidine salvage reactions, Canis familiaris"
xref: Reactome:REACT_85956 "Pyrimidine salvage reactions, Oryza sativa"
xref: Reactome:REACT_86115 "Pyrimidine salvage reactions, Rattus norvegicus"
xref: Reactome:REACT_89161 "Pyrimidine salvage reactions, Staphylococcus aureus N315"
xref: Reactome:REACT_90574 "Pyrimidine salvage reactions, Schizosaccharomyces pombe"
xref: Reactome:REACT_97914 "Pyrimidine salvage reactions, Danio rerio"
xref: Reactome:REACT_99379 "Pyrimidine salvage reactions, Mus musculus"
is_a: GO:0008655 ! pyrimidine-containing compound salvage
is_a: GO:0043174 ! nucleoside salvage
is_a: GO:0046134 ! pyrimidine nucleoside biosynthetic process

[Term]
id: GO:0043098
name: purine deoxyribonucleoside salvage
namespace: biological_process
def: "Any process which produces a purine deoxyribonucleoside from derivatives of it, without de novo synthesis." [GOC:jl]
subset: gosubset_prok
is_a: GO:0043101 ! purine-containing compound salvage
is_a: GO:0043174 ! nucleoside salvage
is_a: GO:0046123 ! purine deoxyribonucleoside biosynthetic process

[Term]
id: GO:0043099
name: pyrimidine deoxyribonucleoside salvage
namespace: biological_process
def: "Any process that generates a pyrimidine deoxyribonucleoside from derivatives of it, without de novo synthesis." [GOC:jl]
subset: gosubset_prok
is_a: GO:0043097 ! pyrimidine nucleoside salvage
is_a: GO:0046126 ! pyrimidine deoxyribonucleoside biosynthetic process

[Term]
id: GO:0043100
name: pyrimidine nucleobase salvage
namespace: biological_process
def: "Any process that generates pyrimidine nucleobases, 1,3-diazine organic nitrogenous bases, from derivatives of them without de novo synthesis." [CHEBI:26432, GOC:jl]
subset: gosubset_prok
synonym: "pyrimidine base salvage" EXACT [GOC:go_curators]
is_a: GO:0008655 ! pyrimidine-containing compound salvage
is_a: GO:0019856 ! pyrimidine nucleobase biosynthetic process

[Term]
id: GO:0043101
name: purine-containing compound salvage
namespace: biological_process
def: "Any process that generates a purine-containing compound, any nucleobase, nucleoside, nucleotide or nucleic acid that contains a purine base, from derivatives of them without de novo synthesis." [CHEBI:26401, GOC:jl]
subset: goslim_pir
subset: gosubset_prok
synonym: "purine salvage" RELATED [GOC:curators]
xref: Reactome:REACT_101336 "Purine salvage, Schizosaccharomyces pombe"
xref: Reactome:REACT_101369 "Purine salvage, Danio rerio"
xref: Reactome:REACT_103526 "Purine salvage, Plasmodium falciparum"
xref: Reactome:REACT_104777 "Purine salvage, Bos taurus"
xref: Reactome:REACT_108943 "Purine salvage, Saccharomyces cerevisiae"
xref: Reactome:REACT_109288 "Purine salvage, Drosophila melanogaster"
xref: Reactome:REACT_1923 "Purine salvage, Homo sapiens"
xref: Reactome:REACT_28109 "Purine salvage, Dictyostelium discoideum"
xref: Reactome:REACT_28847 "Purine salvage, Escherichia coli"
xref: Reactome:REACT_31632 "Purine salvage, Arabidopsis thaliana"
xref: Reactome:REACT_32479 "Purine salvage, Staphylococcus aureus N315"
xref: Reactome:REACT_78176 "Purine salvage, Oryza sativa"
xref: Reactome:REACT_79232 "Purine salvage, Xenopus tropicalis"
xref: Reactome:REACT_82121 "Purine salvage, Gallus gallus"
xref: Reactome:REACT_82482 "Purine salvage, Taeniopygia guttata"
xref: Reactome:REACT_84877 "Purine salvage, Mus musculus"
xref: Reactome:REACT_88584 "Purine salvage, Sus scrofa"
xref: Reactome:REACT_91689 "Purine salvage, Rattus norvegicus"
xref: Reactome:REACT_92683 "Purine salvage, Mycobacterium tuberculosis"
xref: Reactome:REACT_96464 "Purine salvage, Canis familiaris"
xref: Reactome:REACT_99628 "Purine salvage, Caenorhabditis elegans"
is_a: GO:0034654 ! nucleobase-containing compound biosynthetic process
is_a: GO:0043094 ! cellular metabolic compound salvage
is_a: GO:0072522 ! purine-containing compound biosynthetic process

[Term]
id: GO:0043102
name: amino acid salvage
namespace: biological_process
def: "Any process which produces an amino acid from derivatives of it, without de novo synthesis." [GOC:jl]
subset: gosubset_prok
is_a: GO:0008652 ! cellular amino acid biosynthetic process
is_a: GO:0043094 ! cellular metabolic compound salvage

[Term]
id: GO:0043103
name: hypoxanthine salvage
namespace: biological_process
def: "Any process that generates hypoxanthine, 6-hydroxy purine, from derivatives of it without de novo synthesis." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "adenine, hypoxanthine and their nucleoside salvage" NARROW []
synonym: "guanine, xanthine and their nucleoside salvage" NARROW []
is_a: GO:0043096 ! purine nucleobase salvage
is_a: GO:0046101 ! hypoxanthine biosynthetic process

[Term]
id: GO:0043104
name: positive regulation of GTP cyclohydrolase I activity
namespace: biological_process
def: "Any process that activates or increases the activity of the enzyme GTP cyclohydrolase I." [GOC:jl]
subset: gosubset_prok
synonym: "activation of GTP cyclohydrolase I activity" NARROW []
synonym: "stimulation of GTP cyclohydrolase I activity" NARROW []
synonym: "up regulation of GTP cyclohydrolase I activity" EXACT []
synonym: "up-regulation of GTP cyclohydrolase I activity" EXACT []
synonym: "upregulation of GTP cyclohydrolase I activity" EXACT []
is_a: GO:0043095 ! regulation of GTP cyclohydrolase I activity
is_a: GO:0051345 ! positive regulation of hydrolase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003934 ! GTP cyclohydrolase I activity
relationship: positively_regulates GO:0003934 ! GTP cyclohydrolase I activity

[Term]
id: GO:0043105
name: negative regulation of GTP cyclohydrolase I activity
namespace: biological_process
def: "Any process that stops or reduces the activity of the enzyme GTP cyclohydrolase I." [GOC:jl]
subset: gosubset_prok
synonym: "down regulation of GTP cyclohydrolase I activity" EXACT []
synonym: "down-regulation of GTP cyclohydrolase I activity" EXACT []
synonym: "downregulation of GTP cyclohydrolase I activity" EXACT []
synonym: "inhibition of GTP cyclohydrolase I activity" NARROW []
is_a: GO:0043095 ! regulation of GTP cyclohydrolase I activity
is_a: GO:0051346 ! negative regulation of hydrolase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003934 ! GTP cyclohydrolase I activity
relationship: negatively_regulates GO:0003934 ! GTP cyclohydrolase I activity

[Term]
id: GO:0043107
name: type IV pilus-dependent motility
namespace: biological_process
def: "Any process involved in the controlled movement of a bacterial cell which is dependent on the presence of type IV pili. Includes social gliding motility and twitching motility." [GOC:go_curators, PMID:12704238]
subset: gosubset_prok
synonym: "social gliding motility" NARROW []
synonym: "TFP-dependent motility" EXACT []
synonym: "TFP-dependent movement" EXACT []
synonym: "twitching motility" NARROW []
synonym: "type 4 pilus-dependent motility" EXACT []
synonym: "type four pilus-dependent motility" EXACT []
is_a: GO:0048870 ! cell motility

[Term]
id: GO:0043108
name: pilus retraction
namespace: biological_process
def: "The process of withdrawing a pilus back into a cell." [GOC:go_curators, PMID:17355871]
subset: gosubset_prok
is_a: GO:0043711 ! pilus organization

[Term]
id: GO:0043110
name: rDNA spacer replication fork barrier binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with replication fork barriers found in rDNA spacers, sites that inhibit replication forks in the direction opposite to rDNA transcription." [GOC:jl, GOC:mah, PMID:14645529]
synonym: "RFB binding" EXACT []
is_a: GO:0000182 ! rDNA binding
is_a: GO:0031634 ! replication fork barrier binding

[Term]
id: GO:0043111
name: replication fork arrest
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication by impeding the progress of the DNA replication fork." [GOC:jl, PMID:14645529]
comment: See also the biological process term 'site-specific replication termination ; GO:0071170' and its children.
subset: gosubset_prok
synonym: "negative regulation of DNA replication at replication fork barrier" EXACT [GOC:dph, GOC:tb]
synonym: "replication fork blocking" EXACT []
synonym: "replication fork stalling" EXACT []
is_a: GO:0045005 ! DNA-dependent DNA replication maintenance of fidelity
is_a: GO:2000104 ! negative regulation of DNA-dependent DNA replication

[Term]
id: GO:0043112
name: receptor metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:jl]
subset: gosubset_prok
synonym: "receptor metabolism" EXACT []
is_a: GO:0044260 ! cellular macromolecule metabolic process

[Term]
id: GO:0043113
name: receptor clustering
namespace: biological_process
def: "The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response." [GOC:bf, GOC:jl, GOC:pr, PMID:19747931, PMID:21453460]
is_a: GO:0051668 ! localization within membrane
is_a: GO:0072657 ! protein localization to membrane
relationship: occurs_in GO:0005886 ! plasma membrane

[Term]
id: GO:0043114
name: regulation of vascular permeability
namespace: biological_process
def: "Any process that modulates the extent to which blood vessels can be pervaded by fluid." [GOC:jl]
is_a: GO:0003018 ! vascular process in circulatory system
is_a: GO:0065008 ! regulation of biological quality
relationship: part_of GO:0008015 ! blood circulation

[Term]
id: GO:0043115
name: precorrin-2 dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin." [EC:1.3.1.76, RHEA:15616]
subset: gosubset_prok
synonym: "1,3-dimethyluroporphyrinogen III dehydrogenase activity" EXACT []
synonym: "CysG" RELATED [EC:1.3.1.76]
synonym: "dihydrosirohydrochlorin dehydrogenase activity" EXACT []
synonym: "Met8p" RELATED [EC:1.3.1.76]
synonym: "precorrin-2 oxidase activity" EXACT [EC:1.3.1.76]
synonym: "precorrin-2:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.76]
synonym: "SirC" RELATED [EC:1.3.1.76]
synonym: "siroheme synthase activity" BROAD []
xref: EC:1.3.1.76
xref: KEGG:R03947
xref: MetaCyc:DIMETHUROPORDEHYDROG-RXN
xref: RHEA:15616
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0043116
name: negative regulation of vascular permeability
namespace: biological_process
def: "Any process that reduces the extent to which blood vessels can be pervaded by fluid." [GOC:jl]
synonym: "down regulation of vascular permeability" EXACT []
synonym: "down-regulation of vascular permeability" EXACT []
synonym: "downregulation of vascular permeability" EXACT []
synonym: "inhibition of vascular permeability" NARROW []
is_a: GO:0043114 ! regulation of vascular permeability

[Term]
id: GO:0043117
name: positive regulation of vascular permeability
namespace: biological_process
def: "Any process that increases the extent to which blood vessels can be pervaded by fluid." [GOC:jl]
synonym: "activation of vascular permeability" NARROW []
synonym: "stimulation of vascular permeability" NARROW []
synonym: "up regulation of vascular permeability" EXACT []
synonym: "up-regulation of vascular permeability" EXACT []
synonym: "upregulation of vascular permeability" EXACT []
is_a: GO:0043114 ! regulation of vascular permeability

[Term]
id: GO:0043120
name: tumor necrosis factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages." [GOC:jl, http://lookwayup.com/]
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0043121
name: neurotrophin binding
namespace: molecular_function
alt_id: GO:0048404
alt_id: GO:0048405
def: "Interacting selectively and non-covalently with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth." [GOC:jl, http://www.mercksource.com/, PR:000021998]
comment: Note that mammalian NT-5 was initially named differently from amphibian NT-4 because of sequence differences, but the two genes were later shown to be functionally equivalent [SF:919858].
synonym: "neurotrophin 3 binding" NARROW []
synonym: "neurotrophin 4/5 binding" NARROW []
synonym: "neurotrophin TRK receptor activity" RELATED []
synonym: "neurotrophin TRKA receptor activity" RELATED []
synonym: "neurotrophin TRKB receptor activity" RELATED []
synonym: "neurotrophin TRKC receptor activity" RELATED []
synonym: "neurotrophin-3 binding" NARROW []
synonym: "neurotrophin-4/5 binding" NARROW []
synonym: "NT 4/5 binding" EXACT []
synonym: "NT-3 binding" NARROW []
synonym: "NT-4 binding" NARROW []
synonym: "NT-4/5 binding" NARROW []
synonym: "NT-5 binding" NARROW []
synonym: "NT3 binding" NARROW []
synonym: "NT4 binding" NARROW []
synonym: "NT5 binding" NARROW []
is_a: GO:0019838 ! growth factor binding

[Term]
id: GO:0043122
name: regulation of I-kappaB kinase/NF-kappaB signaling
namespace: biological_process
def: "Any process that modulates I-kappaB kinase/NF-kappaB signaling." [GOC:jl, PMID:12773372]
synonym: "regulation of I-kappaB kinase/NF-kappaB cascade" RELATED [GOC:signaling]
is_a: GO:1902531 ! regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007249 ! I-kappaB kinase/NF-kappaB signaling
relationship: regulates GO:0007249 ! I-kappaB kinase/NF-kappaB signaling

[Term]
id: GO:0043123
name: positive regulation of I-kappaB kinase/NF-kappaB signaling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling." [GOC:jl]
synonym: "activation of I-kappaB kinase/NF-kappaB cascade" RELATED []
synonym: "positive regulation of I-kappaB kinase/NF-kappaB cascade" RELATED [GOC:signaling]
synonym: "stimulation of I-kappaB kinase/NF-kappaB cascade" NARROW []
synonym: "up regulation of I-kappaB kinase/NF-kappaB cascade" RELATED []
synonym: "up-regulation of I-kappaB kinase/NF-kappaB cascade" RELATED []
synonym: "upregulation of I-kappaB kinase/NF-kappaB cascade" RELATED []
xref: Reactome:REACT_24918 "IRAK1 recruits IKK complex, Homo sapiens"
is_a: GO:0043122 ! regulation of I-kappaB kinase/NF-kappaB signaling
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007249 ! I-kappaB kinase/NF-kappaB signaling
relationship: positively_regulates GO:0007249 ! I-kappaB kinase/NF-kappaB signaling

[Term]
id: GO:0043124
name: negative regulation of I-kappaB kinase/NF-kappaB signaling
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling." [GOC:jl]
synonym: "down regulation of I-kappaB kinase/NF-kappaB cascade" RELATED []
synonym: "down-regulation of I-kappaB kinase/NF-kappaB cascade" RELATED []
synonym: "downregulation of I-kappaB kinase/NF-kappaB cascade" RELATED []
synonym: "inhibition of I-kappaB kinase/NF-kappaB cascade" NARROW []
synonym: "negative regulation of I-kappaB kinase/NF-kappaB cascade" RELATED [GOC:signaling]
is_a: GO:0043122 ! regulation of I-kappaB kinase/NF-kappaB signaling
is_a: GO:1902532 ! negative regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007249 ! I-kappaB kinase/NF-kappaB signaling
relationship: negatively_regulates GO:0007249 ! I-kappaB kinase/NF-kappaB signaling

[Term]
id: GO:0043125
name: ErbB-3 class receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the protein-tyrosine kinase receptor ErbB-3/HER3." [GOC:jl]
synonym: "HER3 receptor binding" EXACT []
synonym: "Neu/ErbB-2 receptor activity" RELATED []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0043126
name: regulation of 1-phosphatidylinositol 4-kinase activity
namespace: biological_process
def: "Any process that modulates the activity of the enzyme 1-phosphatidylinositol 4-kinase." [GOC:jl]
subset: gosubset_prok
synonym: "regulation of PI4K activity" EXACT []
is_a: GO:0043550 ! regulation of lipid kinase activity
is_a: GO:1903725 ! regulation of phospholipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004430 ! 1-phosphatidylinositol 4-kinase activity
relationship: regulates GO:0004430 ! 1-phosphatidylinositol 4-kinase activity

[Term]
id: GO:0043127
name: negative regulation of 1-phosphatidylinositol 4-kinase activity
namespace: biological_process
def: "Any process that stops or reduces the activity of the enzyme 1-phosphatidylinositol 4-kinase." [GOC:jl]
subset: gosubset_prok
synonym: "down regulation of 1-phosphatidylinositol 4-kinase activity" EXACT []
synonym: "down-regulation of 1-phosphatidylinositol 4-kinase activity" EXACT []
synonym: "downregulation of 1-phosphatidylinositol 4-kinase activity" EXACT []
synonym: "inhibition of 1-phosphatidylinositol 4-kinase activity" NARROW []
synonym: "negative regulation of PI4K activity" EXACT []
is_a: GO:0043126 ! regulation of 1-phosphatidylinositol 4-kinase activity
is_a: GO:0090219 ! negative regulation of lipid kinase activity
is_a: GO:1903726 ! negative regulation of phospholipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004430 ! 1-phosphatidylinositol 4-kinase activity
relationship: negatively_regulates GO:0004430 ! 1-phosphatidylinositol 4-kinase activity

[Term]
id: GO:0043128
name: positive regulation of 1-phosphatidylinositol 4-kinase activity
namespace: biological_process
def: "Any process that activates or increases the activity of 1-phosphatidylinositol 4-kinase." [GOC:jl]
subset: gosubset_prok
synonym: "activation of 1-phosphatidylinositol 4-kinase activity" NARROW []
synonym: "positive regulation of PI4K activity" EXACT []
synonym: "stimulation of 1-phosphatidylinositol 4-kinase activity" NARROW []
synonym: "up regulation of 1-phosphatidylinositol 4-kinase activity" EXACT []
synonym: "up-regulation of 1-phosphatidylinositol 4-kinase activity" EXACT []
synonym: "upregulation of 1-phosphatidylinositol 4-kinase activity" EXACT []
is_a: GO:0043126 ! regulation of 1-phosphatidylinositol 4-kinase activity
is_a: GO:0090218 ! positive regulation of lipid kinase activity
is_a: GO:1903727 ! positive regulation of phospholipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004430 ! 1-phosphatidylinositol 4-kinase activity
relationship: positively_regulates GO:0004430 ! 1-phosphatidylinositol 4-kinase activity

[Term]
id: GO:0043129
name: surfactant homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of a steady-state level of the surface-active lipoprotein mixture which coats the alveoli." [PMID:9751757]
is_a: GO:0048875 ! chemical homeostasis within a tissue

[Term]
id: GO:0043130
name: ubiquitin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]
xref: Reactome:REACT_103506 "Polyubiquitinated NRIF binds to p62 (Sequestosome), Bos taurus"
xref: Reactome:REACT_115873 "Transfer of ISG15 from E1 to E2 (UBCH8), Homo sapiens"
xref: Reactome:REACT_13460 "Polyubiquitinated NRIF binds to p62 (Sequestosome), Homo sapiens"
xref: Reactome:REACT_75860 "Transfer of ubiquitin from E1 to E2, Homo sapiens"
xref: Reactome:REACT_77056 "Polyubiquitinated NRIF binds to p62 (Sequestosome), Gallus gallus"
xref: Reactome:REACT_78292 "Polyubiquitinated NRIF binds to p62 (Sequestosome), Mus musculus"
xref: Reactome:REACT_80542 "Polyubiquitinated NRIF binds to p62 (Sequestosome), Rattus norvegicus"
xref: Reactome:REACT_90680 "Polyubiquitinated NRIF binds to p62 (Sequestosome), Taeniopygia guttata"
is_a: GO:0032182 ! ubiquitin-like protein binding

[Term]
id: GO:0043131
name: erythrocyte enucleation
namespace: biological_process
def: "The process in which nucleated precursor cells lose their nucleus during erythrocyte maturation." [GOC:hjd]
is_a: GO:0090601 ! enucleation
relationship: part_of GO:0043354 ! enucleate erythrocyte maturation

[Term]
id: GO:0043132
name: NAD transport
namespace: biological_process
def: "The directed movement of nicotinamide adenine dinucleotide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore; transport may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:jl]
synonym: "NAD (oxidized) transport" EXACT []
synonym: "NAD (reduced) transport" EXACT []
synonym: "NADH transport" EXACT []
synonym: "nicotinamide adenine dinucleotide transport" EXACT []
synonym: "oxidized NAD transport" EXACT []
synonym: "oxidized nicotinamide adenine dinucleotide transport" EXACT []
synonym: "reduced NAD transport" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide transport" EXACT []
is_a: GO:0006862 ! nucleotide transport
is_a: GO:0051181 ! cofactor transport

[Term]
id: GO:0043133
name: hindgut contraction
namespace: biological_process
def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the hindgut. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The hindgut is the posterior part of the alimentary canal, including the rectum, and the large intestine." [GOC:jl, GOC:mtg_muscle, UBERON:0001046]
is_a: GO:0006939 ! smooth muscle contraction
is_a: GO:0022600 ! digestive system process

[Term]
id: GO:0043134
name: regulation of hindgut contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine." [GOC:jl, UBERON:0001046]
is_a: GO:0006940 ! regulation of smooth muscle contraction
is_a: GO:0044058 ! regulation of digestive system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043133 ! hindgut contraction
relationship: regulates GO:0043133 ! hindgut contraction

[Term]
id: GO:0043135
name: 5-phosphoribosyl 1-pyrophosphate pyrophosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + H2O = ribose 1,5 bisphosphate + phosphate + H+." [MetaCyc:RXN-10969, PMID:12370170]
synonym: "PRPP pyrophosphatase activity" EXACT []
xref: MetaCyc:RXN-10969
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0043136
name: glycerol-3-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycerol 3-phosphate + H2O = glycerol + phosphate." [GOC:jl]
xref: MetaCyc:GLYCEROL-1-PHOSPHATASE-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0043137
name: DNA replication, removal of RNA primer
namespace: biological_process
def: "Removal of the Okazaki RNA primer from the lagging strand of replicating DNA, by a combination of the actions of DNA polymerase, DNA helicase and an endonuclease." [GOC:jl, PMID:12424238]
subset: gosubset_prok
synonym: "Okazaki initiator RNA removal" EXACT []
is_a: GO:0006259 ! DNA metabolic process
is_a: GO:0006401 ! RNA catabolic process
relationship: part_of GO:0033567 ! DNA replication, Okazaki fragment processing

[Term]
id: GO:0043138
name: 3'-5' DNA helicase activity
namespace: molecular_function
def: "Catalysis of the unwinding of the DNA helix in the direction 3' to 5'." [GOC:jl]
synonym: "3' to 5' DNA helicase activity" EXACT []
is_a: GO:0003678 ! DNA helicase activity

[Term]
id: GO:0043139
name: 5'-3' DNA helicase activity
namespace: molecular_function
def: "Catalysis of the unwinding of the DNA helix in the direction 5' to 3'." [GOC:jl]
synonym: "5' to 3' DNA helicase activity" EXACT []
is_a: GO:0003678 ! DNA helicase activity

[Term]
id: GO:0043140
name: ATP-dependent 3'-5' DNA helicase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 3' to 5'." [GOC:jl]
synonym: "ATP-dependent 3' to 5' DNA helicase activity" EXACT []
is_a: GO:0004003 ! ATP-dependent DNA helicase activity
is_a: GO:0043138 ! 3'-5' DNA helicase activity

[Term]
id: GO:0043141
name: ATP-dependent 5'-3' DNA helicase activity
namespace: molecular_function
alt_id: GO:0008722
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 5' to 3'." [GOC:jl]
synonym: "ATP-dependent 5' to 3' DNA helicase activity" EXACT []
synonym: "DNA helicase IV activity" NARROW []
xref: EC:3.6.1.-
is_a: GO:0004003 ! ATP-dependent DNA helicase activity
is_a: GO:0043139 ! 5'-3' DNA helicase activity

[Term]
id: GO:0043142
name: single-stranded DNA-dependent ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single-stranded DNA, and it drives another reaction." [GOC:go_curators]
synonym: "ssDNA-dependent ATPase activity" EXACT []
is_a: GO:0008094 ! DNA-dependent ATPase activity

[Term]
id: GO:0043143
name: regulation of translation by machinery localization
namespace: biological_process
def: "Any process in which proteins and protein complexes involved in translation are transported to, or maintained in, a specific location." [GOC:jl]
subset: gosubset_prok
synonym: "establishment and maintenance of translational machinery localization" EXACT []
synonym: "establishment and maintenance of translational protein localization" EXACT []
synonym: "regulation of translation by machinery localisation" EXACT [GOC:mah]
synonym: "translational machinery localization" EXACT [GOC:dph, GOC:tb]
synonym: "translational protein localization" EXACT []
is_a: GO:0006417 ! regulation of translation
is_a: GO:0034613 ! cellular protein localization
intersection_of: GO:0008104 ! protein localization
intersection_of: part_of GO:0006412 ! translation
relationship: part_of GO:0006412 ! translation

[Term]
id: GO:0043144
name: snoRNA processing
namespace: biological_process
def: "Any process involved in the conversion of a primary small nucleolar RNA (snoRNA) transcript into a mature snoRNA." [GOC:go_curators, PMID:12773397]
subset: goslim_yeast
is_a: GO:0016074 ! snoRNA metabolic process
is_a: GO:0034470 ! ncRNA processing

[Term]
id: GO:0043145
name: snoRNA 3'-end cleavage
namespace: biological_process
def: "The endonucleolytic cleavage of snoRNA 3' ends, which is required for mature snoRNAs to be functional." [GOC:go_curators, PMID:12773397]
synonym: "snoRNA 3' end cleavage" EXACT []
is_a: GO:0031126 ! snoRNA 3'-end processing
is_a: GO:0090502 ! RNA phosphodiester bond hydrolysis, endonucleolytic

[Term]
id: GO:0043149
name: stress fiber assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a stress fiber. A stress fiber is a contractile actin filament bundle that consists of short actin filaments with alternating polarity." [GOC:go_curators, GOC:mah, PMID:16651381]
synonym: "actin cable assembly" RELATED [GOC:mah]
synonym: "actin cable formation" RELATED [GOC:mah]
synonym: "stress fibre biosynthesis" RELATED []
synonym: "stress fibre formation" RELATED []
is_a: GO:0030038 ! contractile actin filament bundle assembly
is_a: GO:0031032 ! actomyosin structure organization

[Term]
id: GO:0043150
name: DNA synthesis involved in double-strand break repair via homologous recombination
namespace: biological_process
def: "The synthesis of DNA that contributes to the process of double-strand break repair via homologous recombination." [GOC:go_curators]
subset: gosubset_prok
synonym: "DNA synthesis during double-strand break repair via homologous recombination" RELATED [GOC:dph, GOC:tb]
is_a: GO:0000731 ! DNA synthesis involved in DNA repair
intersection_of: GO:0071897 ! DNA biosynthetic process
intersection_of: part_of GO:0000724 ! double-strand break repair via homologous recombination
relationship: part_of GO:0000724 ! double-strand break repair via homologous recombination

[Term]
id: GO:0043151
name: DNA synthesis involved in double-strand break repair via single-strand annealing
namespace: biological_process
def: "The synthesis of DNA that contributes to the process of double-strand break repair via single-strand annealing." [GOC:go_curators]
subset: gosubset_prok
synonym: "DNA synthesis during double-strand break repair via single-strand annealing" RELATED [GOC:dph, GOC:tb]
is_a: GO:0000731 ! DNA synthesis involved in DNA repair
intersection_of: GO:0071897 ! DNA biosynthetic process
intersection_of: part_of GO:0045002 ! double-strand break repair via single-strand annealing
relationship: part_of GO:0045002 ! double-strand break repair via single-strand annealing

[Term]
id: GO:0043152
name: induction of bacterial agglutination
namespace: biological_process
def: "Any process in which infecting bacteria are clumped together by a host organism." [GOC:jl]
is_a: GO:0019731 ! antibacterial humoral response

[Term]
id: GO:0043153
name: entrainment of circadian clock by photoperiod
namespace: biological_process
def: "The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night)." [GOC:jl]
synonym: "photoentrainment of circadian clock" EXACT [PMID:10217146]
is_a: GO:0009648 ! photoperiodism
is_a: GO:0009649 ! entrainment of circadian clock

[Term]
id: GO:0043154
name: negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
namespace: biological_process
alt_id: GO:0001719
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
synonym: "down regulation of caspase activity" EXACT []
synonym: "down-regulation of caspase activity" EXACT []
synonym: "downregulation of caspase activity" EXACT []
synonym: "inhibition of caspase activation" NARROW []
synonym: "inhibition of caspase activity" NARROW []
synonym: "negative regulation of caspase activation" EXACT []
synonym: "negative regulation of caspase activity" BROAD []
is_a: GO:0043066 ! negative regulation of apoptotic process
is_a: GO:0043281 ! regulation of cysteine-type endopeptidase activity involved in apoptotic process
is_a: GO:2000117 ! negative regulation of cysteine-type endopeptidase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097153 ! cysteine-type endopeptidase activity involved in apoptotic process
relationship: negatively_regulates GO:0097153 ! cysteine-type endopeptidase activity involved in apoptotic process
relationship: part_of GO:0006915 ! apoptotic process

[Term]
id: GO:0043155
name: negative regulation of photosynthesis, light reaction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the light-dependent reaction of photosynthesis." [GOC:jl]
synonym: "down regulation of photosynthesis, light reaction" EXACT []
synonym: "down-regulation of photosynthesis, light reaction" EXACT []
synonym: "downregulation of photosynthesis, light reaction" EXACT []
synonym: "inhibition of photosynthesis, light reaction" NARROW []
is_a: GO:0042548 ! regulation of photosynthesis, light reaction
is_a: GO:1905156 ! negative regulation of photosynthesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019684 ! photosynthesis, light reaction
relationship: negatively_regulates GO:0019684 ! photosynthesis, light reaction

[Term]
id: GO:0043156
name: chromatin remodeling in response to cation stress
namespace: biological_process
def: "Structural changes to eukaryotic chromatin occurring as a result of cation stress, an increase or decrease in the concentration of positively charged ions in the environment." [GOC:jl, GOC:vw, PMID:14762213]
is_a: GO:0006338 ! chromatin remodeling
is_a: GO:0071473 ! cellular response to cation stress
is_a: GO:1902589 ! single-organism organelle organization

[Term]
id: GO:0043157
name: response to cation stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of cation stress, an increase or decrease in the concentration of positively charged ions in the environment." [GOC:jl, PMID:14762213]
subset: gosubset_prok
is_a: GO:0009651 ! response to salt stress

[Term]
id: GO:0043158
name: heterocyst differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a heterocyst, a differentiated cell in certain cyanobacteria whose purpose is to fix nitrogen." [GOC:jl]
subset: gosubset_prok
synonym: "heterocyst biosynthesis" EXACT []
synonym: "heterocyst cell differentiation" EXACT []
synonym: "heterocyst formation" EXACT []
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0043159
name: acrosomal matrix
namespace: cellular_component
def: "A structural framework, or 'dense core' at the interior of an acrosome. May regulate the distribution of hydrolases within the acrosome and their release during the acrosome reaction." [GOC:jl, PMID:8949900, PMID:9139729]
is_a: GO:0044433 ! cytoplasmic vesicle part
is_a: GO:0044437 ! vacuolar part
is_a: GO:0097223 ! sperm part
relationship: part_of GO:0001669 ! acrosomal vesicle

[Term]
id: GO:0043160
name: acrosomal lumen
namespace: cellular_component
def: "The volume enclosed within the acrosome membrane." [GOC:go_curators]
is_a: GO:0034774 ! secretory granule lumen
is_a: GO:0043202 ! lysosomal lumen
is_a: GO:0097223 ! sperm part
relationship: part_of GO:0001669 ! acrosomal vesicle

[Term]
id: GO:0043161
name: proteasome-mediated ubiquitin-dependent protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]
synonym: "proteasomal pathway" EXACT []
synonym: "proteasomal processing" RELATED []
synonym: "proteasomal ubiquitin-dependent protein breakdown" EXACT []
synonym: "proteasomal ubiquitin-dependent protein catabolic process" EXACT []
synonym: "proteasomal ubiquitin-dependent protein catabolism" EXACT []
synonym: "proteasomal ubiquitin-dependent protein degradation" EXACT []
synonym: "proteasome pathway" RELATED []
xref: Reactome:REACT_103814 "Degradation multiubiquitinated Cyclin A, Xenopus tropicalis"
xref: Reactome:REACT_6937 "Degradation multiubiquitinated Cyclin A, Homo sapiens"
xref: Reactome:REACT_78867 "Degradation multiubiquitinated Cyclin A, Rattus norvegicus"
xref: Reactome:REACT_80748 "Degradation multiubiquitinated Cyclin A, Bos taurus"
xref: Reactome:REACT_88610 "Degradation multiubiquitinated Cyclin A, Canis familiaris"
xref: Reactome:REACT_88818 "Degradation multiubiquitinated Cyclin A, Drosophila melanogaster"
xref: Reactome:REACT_96387 "Degradation multiubiquitinated Cyclin A, Mus musculus"
xref: Reactome:REACT_97709 "Degradation multiubiquitinated Cyclin A, Danio rerio"
is_a: GO:0006511 ! ubiquitin-dependent protein catabolic process
is_a: GO:0010498 ! proteasomal protein catabolic process

[Term]
id: GO:0043162
name: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation." [GOC:jl, PMID:11511343]
synonym: "ubiquitin-dependent protein breakdown via the multivesicular body pathway" EXACT []
synonym: "ubiquitin-dependent protein catabolic process via the MVB pathway" EXACT []
synonym: "ubiquitin-dependent protein catabolism via the MVB pathway" EXACT []
synonym: "ubiquitin-dependent protein degradation via the multivesicular body pathway" EXACT []
is_a: GO:0006511 ! ubiquitin-dependent protein catabolic process
relationship: has_part GO:0007039 ! protein catabolic process in the vacuole
relationship: has_part GO:0071985 ! multivesicular body sorting pathway

[Term]
id: GO:0043163
name: cell envelope organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell envelope, everything external to, but not including, the cytoplasmic membrane of bacteria, encompassing the periplasmic space, cell wall, and outer membrane if present." [GOC:jl]
subset: goslim_pir
subset: gosubset_prok
synonym: "cell envelope organisation" EXACT [GOC:curators]
synonym: "cell envelope organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0045229 ! external encapsulating structure organization

[Term]
id: GO:0043164
name: Gram-negative-bacterium-type cell wall biogenesis
namespace: biological_process
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cell wall of the type found in Gram-negative bacteria. The cell wall is the rigid or semi-rigid envelope lying outside the cell membrane." [GOC:jl, GOC:mtg_sensu, ISBN:0815108893]
subset: gosubset_prok
synonym: "1-2nm peptidoglycan-based cell wall biogenesis" EXACT []
synonym: "cell wall anabolism" BROAD []
synonym: "cell wall assembly" BROAD []
synonym: "cell wall biosynthetic process" BROAD []
synonym: "cell wall formation" BROAD []
synonym: "cell wall synthesis" BROAD []
is_a: GO:0009273 ! peptidoglycan-based cell wall biogenesis

[Term]
id: GO:0043165
name: Gram-negative-bacterium-type cell outer membrane assembly
namespace: biological_process
def: "The assembly of an outer membrane of the type formed in Gram-negative bacteria. This membrane is enriched in polysaccharide and protein, and the outer leaflet of the membrane contains specific lipopolysaccharide structures." [GOC:jl, ISBN:0135712254]
subset: gosubset_prok
synonym: "cell outer membrane biogenesis" RELATED [GOC:mah]
is_a: GO:0071709 ! membrane assembly
relationship: part_of GO:0043163 ! cell envelope organization

[Term]
id: GO:0043167
name: ion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with ions, charged atoms or groups of atoms." [GOC:jl]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
synonym: "atom binding" RELATED []
is_a: GO:0005488 ! binding

[Term]
id: GO:0043168
name: anion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with anions, charged atoms or groups of atoms with a net negative charge." [GOC:jl]
subset: gosubset_prok
is_a: GO:0043167 ! ion binding

[Term]
id: GO:0043169
name: cation binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge." [GOC:jl]
subset: gosubset_prok
is_a: GO:0043167 ! ion binding

[Term]
id: GO:0043170
name: macromolecule metabolic process
namespace: biological_process
alt_id: GO:0043283
def: "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [CHEBI:33694, GOC:mah]
subset: goslim_pir
subset: gosubset_prok
synonym: "biopolymer metabolic process" EXACT [GOC:mtg_chebi_dec09]
synonym: "macromolecule metabolism" EXACT []
is_a: GO:0071704 ! organic substance metabolic process

[Term]
id: GO:0043171
name: peptide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:jl]
subset: gosubset_prok
synonym: "peptide breakdown" EXACT []
synonym: "peptide catabolism" EXACT []
synonym: "peptide degradation" EXACT []
is_a: GO:0006518 ! peptide metabolic process
is_a: GO:0044248 ! cellular catabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process

[Term]
id: GO:0043172
name: ferredoxin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ferredoxin, any simple, nonenzymatic iron-sulfur protein that is characterized by having equal numbers of atoms of iron and labile sulfur. Iron and sulfur atoms are present in one or two clusters of two or four atoms of each." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "ferredoxin anabolism" EXACT []
synonym: "ferredoxin biosynthesis" EXACT []
synonym: "ferredoxin formation" EXACT []
synonym: "ferredoxin synthesis" EXACT []
is_a: GO:0006124 ! ferredoxin metabolic process
is_a: GO:0034645 ! cellular macromolecule biosynthetic process

[Term]
id: GO:0043173
name: nucleotide salvage
namespace: biological_process
def: "Any process which produces a nucleotide, a compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety, from derivatives of it without de novo synthesis." [GOC:jl]
subset: gosubset_prok
xref: Wikipedia:Nucleotide_salvage
is_a: GO:0009165 ! nucleotide biosynthetic process
is_a: GO:0043094 ! cellular metabolic compound salvage

[Term]
id: GO:0043174
name: nucleoside salvage
namespace: biological_process
def: "Any process which produces a nucleotide, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose (a deoxyribonucleotide), from derivatives of it without de novo synthesis." [GOC:jl]
subset: gosubset_prok
is_a: GO:0009163 ! nucleoside biosynthetic process
is_a: GO:0043094 ! cellular metabolic compound salvage

[Term]
id: GO:0043175
name: RNA polymerase core enzyme binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase core enzyme, containing a specific subunit composition defined as the core enzyme." [GOC:jl, GOC:txnOH]
subset: gosubset_prok
is_a: GO:0070063 ! RNA polymerase binding

[Term]
id: GO:0043176
name: amine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any organic compound that is weakly basic in character and contains an amino or a substituted amino group." [GOC:jl]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0043177
name: organic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an organic acid, any acidic compound containing carbon in covalent linkage." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0036094 ! small molecule binding

[Term]
id: GO:0043178
name: alcohol binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an alcohol, any of a class of alkyl compounds containing a hydroxyl group." [GOC:jl, ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0036094 ! small molecule binding

[Term]
id: GO:0043179
name: rhythmic excitation
namespace: biological_process
def: "Any process involved in the generation of rhythmic, synchronous excitatory synaptic inputs in a neural circuit." [GOC:go_curators, ISBN:0195088433]
is_a: GO:0060024 ! rhythmic synaptic transmission

[Term]
id: GO:0043180
name: rhythmic inhibition
namespace: biological_process
def: "Any process involved in the generation of rhythmic, synchronous inhibitory synaptic inputs in a neural circuit." [GOC:go_curators]
is_a: GO:0060024 ! rhythmic synaptic transmission

[Term]
id: GO:0043181
name: vacuolar sequestering
namespace: biological_process
def: "The process of transporting a substance into, and confining within, a vacuole." [GOC:jl]
synonym: "retention in vacuole" EXACT []
synonym: "sequestering in vacuole" EXACT []
synonym: "sequestration in vacuole" EXACT []
synonym: "storage in vacuole" EXACT []
synonym: "vacuolar retention" EXACT []
synonym: "vacuolar sequestration" EXACT []
synonym: "vacuolar storage" EXACT []
is_a: GO:0051651 ! maintenance of location in cell

[Term]
id: GO:0043182
name: vacuolar sequestering of sodium ion
namespace: biological_process
def: "The process of transporting sodium ions into, and confining within, a vacuole." [GOC:jl]
synonym: "sequestering of sodium ion (Na+) in vacuole" EXACT []
synonym: "sequestration of sodium ion (Na+) in vacuole" EXACT []
synonym: "sodium ion (Na+) retention in vacuole" EXACT []
synonym: "sodium ion (Na+) storage in vacuole" EXACT []
synonym: "vacuolar sequestering of sodium ion (Na+)" EXACT []
synonym: "vacuolar sequestration of sodium ion (Na+)" EXACT []
synonym: "vacuolar sodium ion (Na+) retention" EXACT []
synonym: "vacuolar sodium ion (Na+) storage" EXACT []
is_a: GO:0043181 ! vacuolar sequestering
relationship: part_of GO:0006883 ! cellular sodium ion homeostasis

[Term]
id: GO:0043183
name: vascular endothelial growth factor receptor 1 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with vascular endothelial growth factor receptor 1." [GOC:st]
synonym: "Flt-1 binding" EXACT []
synonym: "VEGF receptor 1 binding" EXACT []
synonym: "VEGFR 1 binding" EXACT []
is_a: GO:0005172 ! vascular endothelial growth factor receptor binding

[Term]
id: GO:0043184
name: vascular endothelial growth factor receptor 2 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with vascular endothelial growth factor receptor 2." [GOC:st]
synonym: "Flk-1 binding" EXACT []
synonym: "KDR binding" BROAD []
synonym: "kinase domain region binding" EXACT []
synonym: "VEGF receptor 2 binding" EXACT []
synonym: "VEGFR 2 binding" EXACT []
is_a: GO:0005172 ! vascular endothelial growth factor receptor binding

[Term]
id: GO:0043185
name: vascular endothelial growth factor receptor 3 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with vascular endothelial growth factor receptor 3." [GOC:st]
synonym: "fms-like-tyrosine kinase (Flt)-4 binding" EXACT []
synonym: "VEGF receptor 3 binding" EXACT []
synonym: "VEGFR 3 binding" EXACT []
is_a: GO:0005172 ! vascular endothelial growth factor receptor binding

[Term]
id: GO:0043186
name: P granule
namespace: cellular_component
alt_id: GO:0018994
def: "A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230]
synonym: "germline granule" EXACT []
synonym: "nuage" BROAD []
synonym: "polar granule" EXACT []
is_a: GO:0036464 ! cytoplasmic ribonucleoprotein granule
relationship: part_of GO:0060293 ! germ plasm

[Term]
id: GO:0043187
name: cell septum surface
namespace: cellular_component
def: "The extracellular (rather than the intracellular) exterior of a dividing septum; this surface is usually composed of cell wall material, for example, lineal (1,3)-beta-D-glucan in S. pombe." [GOC:go_curators]
synonym: "septum surface" BROAD []
is_a: GO:0044457 ! cell septum part

[Term]
id: GO:0043188
name: cell septum edging
namespace: cellular_component
def: "The cell wall material that surrounds the septum in fungal cells." [GOC:vw]
is_a: GO:0044426 ! cell wall part
relationship: part_of GO:0009277 ! fungal-type cell wall

[Term]
id: GO:0043189
name: H4/H2A histone acetyltransferase complex
namespace: cellular_component
def: "A multisubunit complex that catalyzes the acetylation of histones H4 and H2A." [GOC:mah, GOC:rb]
synonym: "H4/H2A HAT complex" EXACT []
is_a: GO:1902562 ! H4 histone acetyltransferase complex

[Term]
id: GO:0043190
name: ATP-binding cassette (ABC) transporter complex
namespace: cellular_component
alt_id: GO:0043191
alt_id: GO:0043192
def: "A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter." [GOC:jl, GOC:mtg_sensu, PMID:11421269, PMID:15111107]
subset: goslim_metagenomics
subset: goslim_pir
subset: gosubset_prok
synonym: "ABC-type efflux permease complex" NARROW []
synonym: "ABC-type efflux porter complex" NARROW []
synonym: "ABC-type uptake permease complex" NARROW []
synonym: "ATP-binding cassette (ABC) transporter complex" RELATED []
synonym: "mating pheromone exporter" NARROW []
is_a: GO:0098533 ! ATPase dependent transmembrane transport complex
is_a: GO:0098797 ! plasma membrane protein complex
relationship: part_of GO:0005886 ! plasma membrane

[Term]
id: GO:0043194
name: axon initial segment
namespace: cellular_component
def: "Portion of the axon proximal to the neuronal cell body, at the level of the axon hillock. The action potentials that propagate along the axon are generated at the level of this initial segment." [GOC:nln, GOC:sl, PMID:1754851, PMID:21551097]
synonym: "initial segment" EXACT []
xref: NIF_Subcellular:sao256000789
is_a: GO:0033267 ! axon part
relationship: part_of GO:0044304 ! main axon

[Term]
id: GO:0043195
name: terminal bouton
namespace: cellular_component
def: "Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc, GOC:nln, PMID:10218156, PMID:8409967]
synonym: "bouton" EXACT []
synonym: "presynaptic bouton" EXACT []
synonym: "synaptic bouton" EXACT [NIF_Subcellular:sao187426937]
synonym: "terminal button" EXACT []
xref: NIF_Subcellular:sao187426937
is_a: GO:0033267 ! axon part
is_a: GO:0098793 ! presynapse
relationship: part_of GO:0043679 ! axon terminus

[Term]
id: GO:0043196
name: varicosity
namespace: cellular_component
def: "Non-terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters." [GOC:nln]
is_a: GO:0033267 ! axon part
relationship: part_of GO:0044304 ! main axon

[Term]
id: GO:0043197
name: dendritic spine
namespace: cellular_component
def: "A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse.  They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including \"thin\", \"stubby\", \"mushroom\", and \"branched\", with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity." [GOC:nln]
subset: goslim_synapse
synonym: "branched dendritic spine" NARROW [NIF_Subcellular:sao-965204139]
synonym: "dendrite spine" EXACT []
synonym: "mushroom dendritic spine" NARROW [NIF_Subcellular:sao-876577163]
synonym: "sessile dendritic spine" NARROW [NIF_Subcellular:sao1536532595]
synonym: "stubby dendritic spine" NARROW [NIF_Subcellular:sao317384566]
synonym: "thin dendritic spine" NARROW [NIF_Subcellular:sao1232858786]
xref: NIF_Subcellular:sao1799103720
xref: Wikipedia:Dendritic_spine
is_a: GO:0044309 ! neuron spine
is_a: GO:0044463 ! cell projection part
is_a: GO:0098794 ! postsynapse
relationship: part_of GO:0030425 ! dendrite

[Term]
id: GO:0043198
name: dendritic shaft
namespace: cellular_component
def: "Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines." [GOC:nln]
synonym: "trunk" RELATED [NIF_Subcellular:sao1078172392]
xref: NIF_Subcellular:sao2034472720
is_a: GO:0044463 ! cell projection part
is_a: GO:0097458 ! neuron part
relationship: part_of GO:0030425 ! dendrite

[Term]
id: GO:0043199
name: sulfate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with sulfate, SO4(2-), a negatively charged small molecule." [GOC:mlg]
subset: gosubset_prok
is_a: GO:0043168 ! anion binding
is_a: GO:1901681 ! sulfur compound binding

[Term]
id: GO:0043200
name: response to amino acid
namespace: biological_process
alt_id: GO:0010237
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups." [CHEBI:33709, GOC:ef, GOC:mlg]
synonym: "response to amino acid stimulus" EXACT [GOC:dos]
is_a: GO:0001101 ! response to acid chemical
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0043201
name: response to leucine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leucine stimulus." [GOC:mlg]
is_a: GO:0043200 ! response to amino acid

[Term]
id: GO:0043202
name: lysosomal lumen
namespace: cellular_component
def: "The volume enclosed within the lysosomal membrane." [GOC:jl, PMID:15213228]
is_a: GO:0005775 ! vacuolar lumen
relationship: part_of GO:0005764 ! lysosome

[Term]
id: GO:0043203
name: axon hillock
namespace: cellular_component
def: "Portion of the neuronal cell soma from which the axon originates." [GOC:nln]
xref: NIF_Subcellular:sao627227260
xref: Wikipedia:Axon_hillock
is_a: GO:0033267 ! axon part
relationship: part_of GO:0043025 ! neuronal cell body

[Term]
id: GO:0043204
name: perikaryon
namespace: cellular_component
def: "The portion of the cell soma (cell body) that excludes the nucleus." [GOC:jl]
synonym: "cell soma cytoplasm" RELATED []
is_a: GO:0097458 ! neuron part
relationship: part_of GO:0043025 ! neuronal cell body

[Term]
id: GO:0043205
name: fibril
namespace: cellular_component
def: "Extracellular matrix material consisting of polysaccharides and protein." [PMID:12704238]
is_a: GO:0044420 ! extracellular matrix component
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005578 ! proteinaceous extracellular matrix

[Term]
id: GO:0043206
name: extracellular fibril organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of extracellular fibrils, extracellular matrix material consisting of polysaccharides and/or proteins." [GOC:mlg, GOC:pr]
synonym: "extracellular fibril organisation" EXACT [GOC:curators]
synonym: "extracellular fibril organization and biogenesis" RELATED [GOC:mah]
synonym: "fibril organization" BROAD []
is_a: GO:0097435 ! fibril organization
relationship: occurs_in GO:0031012 ! extracellular matrix

[Term]
id: GO:0043207
name: response to external biotic stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0009605 ! response to external stimulus
is_a: GO:0009607 ! response to biotic stimulus

[Term]
id: GO:0043208
name: glycosphingolipid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide." [GOC:jl]
is_a: GO:0046625 ! sphingolipid binding
is_a: GO:0051861 ! glycolipid binding

[Term]
id: GO:0043209
name: myelin sheath
namespace: cellular_component
def: "An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system." [GOC:cjm, GOC:jl, NIF_Subcellular:sao-593830697, Wikipedia:Myelin]
synonym: "astrocyte sheath" NARROW [NIF_Subcellular:nlx_subcell_20090204]
synonym: "oligodendrocyte myelin sheath" NARROW [NIF_Subcellular:sao1279474730]
synonym: "Schwann cell myelin sheath" NARROW []
xref: FMA:62983
xref: NIF_Subcellular:sao-593830697
xref: Wikipedia:Myelin
is_a: GO:0044464 ! cell part

[Term]
id: GO:0043210
name: alkanesulfonate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon group." [GOC:mlg]
subset: gosubset_prok
is_a: GO:0043168 ! anion binding
is_a: GO:1901681 ! sulfur compound binding

[Term]
id: GO:0043211
name: carbohydrate-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of carbohydrates across a membrane." [GOC:mlg]
subset: gosubset_prok
synonym: "carbohydrate ABC transporter" NARROW []
is_a: GO:0015144 ! carbohydrate transmembrane transporter activity
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances

[Term]
id: GO:0043212
name: carbohydrate-exporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + carbohydrate(in) -> ADP + phosphate + carbohydrate(out)." [GOC:mlg]
subset: gosubset_prok
is_a: GO:0043211 ! carbohydrate-transporting ATPase activity

[Term]
id: GO:0043213
name: bacteriocin transport
namespace: biological_process
def: "The directed movement of a bacteriocin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Bacteriocins are a group of antibiotics produced by bacteria and are encoded by a group of naturally occurring plasmids, e.g. Col E1. Bacteriocins are toxic to bacteria closely related to the bacteriocin producing strain." [GOC:mlg]
subset: gosubset_prok
is_a: GO:0015833 ! peptide transport

[Term]
id: GO:0043214
name: bacteriocin-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of bacteriocins across a membrane." [GOC:mlg]
synonym: "bacteriocin ABC transporter" NARROW []
is_a: GO:0015462 ! protein-transmembrane transporting ATPase activity
is_a: GO:0022885 ! bacteriocin transmembrane transporter activity

[Term]
id: GO:0043215
name: daunorubicin transport
namespace: biological_process
def: "The directed movement of daunorubicin, an anthracycline antibiotic produced by Streptomyces coeruleorubidus or S. peucetius and used as an antineoplastic into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, GOC:mlg, http://www.mercksource.com/]
is_a: GO:0015695 ! organic cation transport
is_a: GO:0015696 ! ammonium transport
is_a: GO:0015893 ! drug transport
is_a: GO:1901656 ! glycoside transport

[Term]
id: GO:0043216
name: daunorubicin-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O + daunorubicin(in) = ADP + phosphate + daunorubicin(out)." [GOC:mlg]
synonym: "daunorubicin ABC transporter" NARROW []
xref: RHEA:33150
is_a: GO:0015238 ! drug transmembrane transporter activity
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances
relationship: part_of GO:0043215 ! daunorubicin transport

[Term]
id: GO:0043217
name: myelin maintenance
namespace: biological_process
def: "The process of preserving the structure and function of mature myelin. This includes maintaining the compact structure of myelin necessary for its electrical insulating characteristics as well as the structure of non-compact regions such as Schmidt-Lantermann clefts and paranodal loops. This does not include processes responsible for maintaining the nodes of Ranvier, which are not part of the myelin sheath." [GOC:dgh]
is_a: GO:0007009 ! plasma membrane organization
relationship: part_of GO:0042552 ! myelination

[Term]
id: GO:0043218
name: compact myelin
namespace: cellular_component
def: "The portion of the myelin sheath in which layers of cell membrane are tightly juxtaposed, completely excluding cytoplasm. The juxtaposed cytoplasmic surfaces form the major dense line, while the juxtaposed extracellular surfaces form the interperiod line visible in electron micrographs." [GOC:dgh, NIF_Subcellular:sao-1123256993]
synonym: "oligodendrocyte compact myelin" NARROW [NIF_Subcellular:sao1186642361]
synonym: "Schwann cell compact myelin" NARROW []
xref: NIF_Subcellular:sao-1123256993
is_a: GO:0044464 ! cell part
relationship: part_of GO:0043209 ! myelin sheath

[Term]
id: GO:0043219
name: lateral loop
namespace: cellular_component
def: "Non-compact myelin located adjacent to the nodes of Ranvier in a myelin segment. These non-compact regions include cytoplasm from the cell responsible for synthesizing the myelin. Lateral loops are found in the paranodal region adjacent to the nodes of Ranvier, while Schmidt-Lantermann clefts are analogous structures found within the compact myelin internode." [GOC:dgh]
synonym: "oligodendrocyte paranodal termination" RELATED [NIF_Subcellular:sao1354781919]
synonym: "paranodal loop" RELATED [NIF_Subcellular:sao1354781919]
synonym: "Schwann cell paranodal termination" RELATED [NIF_Subcellular:sao-1067215520]
xref: NIF_Subcellular:sao-1067215520
xref: NIF_Subcellular:sao1354781919
is_a: GO:0044464 ! cell part
relationship: part_of GO:0043209 ! myelin sheath

[Term]
id: GO:0043220
name: Schmidt-Lanterman incisure
namespace: cellular_component
alt_id: GO:0044287
def: "Regions within compact myelin in which the cytoplasmic faces of the enveloping myelin sheath are not tightly juxtaposed, and include cytoplasm from the cell responsible for making the myelin. Schmidt-Lanterman incisures occur in the compact myelin internode, while lateral loops are analogous structures found in the paranodal region adjacent to the nodes of Ranvier." [GOC:dgh]
synonym: "Schmidt-Lanterman cleft" EXACT []
xref: NIF_Subcellular:sao254777664
is_a: GO:0044464 ! cell part
relationship: part_of GO:0043218 ! compact myelin

[Term]
id: GO:0043221
name: SMC family protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any protein from the structural maintenance of chromosomes (SMC) family, a group of chromosomal ATPases with a role in mitotic chromosome organization." [GOC:jl, GOC:vw, InterPro:IPR024704, PMID:9640531]
synonym: "structural maintenance of chromosomes family protein binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0043223
name: cytoplasmic SCF ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex, located in the cytoplasm, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]
synonym: "cytoplasmic cullin complex" EXACT []
synonym: "cytoplasmic SCF complex" EXACT []
synonym: "cytoplasmic Skp1/Cul1/F-box protein complex" EXACT []
is_a: GO:0000153 ! cytoplasmic ubiquitin ligase complex
is_a: GO:0019005 ! SCF ubiquitin ligase complex
intersection_of: GO:0019005 ! SCF ubiquitin ligase complex
intersection_of: part_of GO:0005737 ! cytoplasm
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0043224
name: nuclear SCF ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex, located in the nucleus, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]
synonym: "nuclear cullin complex" EXACT []
synonym: "nuclear SCF complex" EXACT []
synonym: "nuclear Skp1/Cul1/F-box protein complex" EXACT []
is_a: GO:0000152 ! nuclear ubiquitin ligase complex
is_a: GO:0019005 ! SCF ubiquitin ligase complex
intersection_of: GO:0019005 ! SCF ubiquitin ligase complex
intersection_of: part_of GO:0005634 ! nucleus
relationship: part_of GO:0005634 ! nucleus

[Term]
id: GO:0043225
name: anion transmembrane-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + anion(out) = ADP + phosphate + anion(in)." [GOC:mlg]
subset: gosubset_prok
synonym: "anion ABC transporter" NARROW []
synonym: "anion-transporting ATPase activity" EXACT []
xref: Reactome:REACT_111162 "The ABCC family mediates organic anion transport, Homo sapiens"
is_a: GO:0008509 ! anion transmembrane transporter activity
is_a: GO:0042625 ! ATPase coupled ion transmembrane transporter activity

[Term]
id: GO:0043226
name: organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_pir
subset: gosubset_prok
xref: NIF_Subcellular:sao1539965131
xref: Wikipedia:Organelle
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0043227
name: membrane-bounded organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]
subset: gosubset_prok
synonym: "membrane-enclosed organelle" EXACT []
xref: NIF_Subcellular:sao414196390
is_a: GO:0043226 ! organelle

[Term]
id: GO:0043228
name: non-membrane-bounded organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]
subset: gosubset_prok
synonym: "non-membrane-enclosed organelle" EXACT []
xref: NIF_Subcellular:sao1456184038
is_a: GO:0043226 ! organelle

[Term]
id: GO:0043229
name: intracellular organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0043226 ! organelle
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0043230
name: extracellular organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0043226 ! organelle
is_a: GO:0044421 ! extracellular region part
intersection_of: GO:0043226 ! organelle
intersection_of: part_of GO:0005576 ! extracellular region
relationship: part_of GO:0005576 ! extracellular region

[Term]
id: GO:0043231
name: intracellular membrane-bounded organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]
subset: goslim_pir
subset: gosubset_prok
synonym: "intracellular membrane-enclosed organelle" EXACT []
is_a: GO:0043227 ! membrane-bounded organelle
is_a: GO:0043229 ! intracellular organelle

[Term]
id: GO:0043232
name: intracellular non-membrane-bounded organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]
subset: goslim_pir
subset: gosubset_prok
synonym: "intracellular non-membrane-enclosed organelle" EXACT []
is_a: GO:0043228 ! non-membrane-bounded organelle
is_a: GO:0043229 ! intracellular organelle

[Term]
id: GO:0043233
name: organelle lumen
namespace: cellular_component
def: "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah]
is_a: GO:0031974 ! membrane-enclosed lumen
is_a: GO:0044422 ! organelle part

[Term]
id: GO:0043234
name: protein complex
namespace: cellular_component
def: "A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/]
comment: A protein complex in this context is meant as a stable set of interacting proteins which can be co-purified by an acceptable method, and where the complex has been shown to exist as an isolated, functional unit in vivo. Acceptable experimental methods include stringent protein purification followed by detection of protein interaction. The following methods should be considered non-acceptable: simple immunoprecipitation, pull-down experiments from cell extracts without further purification, colocalization and 2-hybrid screening. Interactions that should not be captured as protein complexes include: 1) enzyme/substrate, receptor/ligand or any similar transient interactions, unless these are a critical part of the complex assembly or are required e.g. for the receptor to be functional; 2) proteins associated in a pull-down/co-immunoprecipitation assay with no functional link or any evidence that this is a defined biological entity rather than a loose-affinity complex; 3) any complex where the only evidence is based on genetic interaction data; 4) partial complexes, where some subunits (e.g. transmembrane ones) cannot be expressed as recombinant proteins and are excluded from experiments (in this case, independent evidence is necessary to find out the composition of the full complex, if known). Interactions that may be captured as protein complexes include: 1) enzyme/substrate or receptor/ligand if the complex can only assemble and become functional in the presence of both classes of subunits; 2) complexes where one of the members has not been shown to be physically linked to the other(s), but is a homologue of, and has the same functionality as, a protein that has been experimentally demonstrated to form a complex with the other member(s); 3) complexes whose existence is accepted based on localization and pharmacological studies, but for which experimental evidence is not yet available for the complex as a whole.
subset: goslim_chembl
subset: goslim_generic
subset: goslim_pir
subset: gosubset_prok
synonym: "protein-protein complex" EXACT []
xref: Wikipedia:Protein_complex
is_a: GO:0032991 ! macromolecular complex

[Term]
id: GO:0043235
name: receptor complex
namespace: cellular_component
def: "Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0043236
name: laminin binding
namespace: molecular_function
alt_id: GO:0043238
alt_id: GO:0043239
def: "Interacting selectively and non-covalently with laminins, glycoproteins that are major constituents of the basement membrane of cells." [GOC:ecd]
synonym: "laminin-2 binding" NARROW []
synonym: "laminin-4 binding" NARROW []
is_a: GO:0005515 ! protein binding
is_a: GO:0050840 ! extracellular matrix binding

[Term]
id: GO:0043237
name: laminin-1 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with laminin-1, a glycoprotein trimer with the subunit composition alpha1, beta1, gamma1." [GOC:go_curators]
is_a: GO:0043236 ! laminin binding

[Term]
id: GO:0043240
name: Fanconi anaemia nuclear complex
namespace: cellular_component
def: "A protein complex composed of the Fanconi anaemia (FA) proteins including A, C, E, G and F (FANCA-F). Functions in the activation of the downstream protein FANCD2 by monoubiquitylation, and is essential for protection against chromosome breakage." [GOC:jl, PMID:12093742]
synonym: "FA complex" EXACT []
synonym: "FA core complex" EXACT []
synonym: "FA nuclear complex" EXACT []
synonym: "Fanconi anaemia complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part

[Term]
id: GO:0043241
name: protein complex disassembly
namespace: biological_process
def: "The disaggregation of a protein complex into its constituent components. Protein complexes may have other associated non-protein prosthetic groups, such as nucleic acids, metal ions or carbohydrate groups." [GOC:jl]
subset: gosubset_prok
is_a: GO:0032984 ! macromolecular complex disassembly
is_a: GO:0071822 ! protein complex subunit organization

[Term]
id: GO:0043242
name: negative regulation of protein complex disassembly
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl]
synonym: "down regulation of protein complex disassembly" EXACT []
synonym: "down-regulation of protein complex disassembly" EXACT []
synonym: "downregulation of protein complex disassembly" EXACT []
synonym: "inhibition of protein complex disassembly" NARROW []
is_a: GO:0043244 ! regulation of protein complex disassembly
is_a: GO:0051129 ! negative regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043241 ! protein complex disassembly
relationship: negatively_regulates GO:0043241 ! protein complex disassembly

[Term]
id: GO:0043243
name: positive regulation of protein complex disassembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl]
synonym: "activation of protein complex disassembly" NARROW []
synonym: "stimulation of protein complex disassembly" NARROW []
synonym: "up regulation of protein complex disassembly" EXACT []
synonym: "up-regulation of protein complex disassembly" EXACT []
synonym: "upregulation of protein complex disassembly" EXACT []
is_a: GO:0043244 ! regulation of protein complex disassembly
is_a: GO:0051130 ! positive regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043241 ! protein complex disassembly
relationship: positively_regulates GO:0043241 ! protein complex disassembly

[Term]
id: GO:0043244
name: regulation of protein complex disassembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl]
subset: gosubset_prok
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043241 ! protein complex disassembly
relationship: regulates GO:0043241 ! protein complex disassembly

[Term]
id: GO:0043245
name: extraorganismal space
namespace: cellular_component
def: "The environmental space outside of an organism; this may be a host organism in the case of parasitic and symbiotic organisms." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044421 ! extracellular region part

[Term]
id: GO:0043246
name: megasome
namespace: cellular_component
def: "Large, cysteine proteinase rich lysosomes, often found in the amastigote (an intracytoplasmic, nonflagellated form of the parasite) stage of Leishmania species belonging to the mexicana complex." [PMID:11206117, PMID:1999020]
is_a: GO:0005764 ! lysosome

[Term]
id: GO:0043247
name: telomere maintenance in response to DNA damage
namespace: biological_process
def: "Any process that occur in response to the presence of critically short or damaged telomeres." [GOC:BHF, GOC:BHF_telomere, GOC:jbu, PMID:15279784]
synonym: "DNA damage response, telomere maintenance" EXACT [GOC:curators]
is_a: GO:0000723 ! telomere maintenance
is_a: GO:0006974 ! cellular response to DNA damage stimulus

[Term]
id: GO:0043248
name: proteasome assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a mature, active proteasome complex." [GOC:go_curators, PMID:10872471]
subset: gosubset_prok
synonym: "26S proteasome assembly" NARROW []
synonym: "proteasome complex assembly" EXACT []
synonym: "proteasome maturation" EXACT []
is_a: GO:0043623 ! cellular protein complex assembly

[Term]
id: GO:0043249
name: erythrocyte maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state." [GOC:devbiol, GOC:jl]
synonym: "RBC maturation" EXACT [CL:0000232]
synonym: "red blood cell maturation" EXACT [CL:0000232]
is_a: GO:0048469 ! cell maturation
relationship: part_of GO:0048821 ! erythrocyte development

[Term]
id: GO:0043250
name: sodium-dependent organic anion transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of organic anions from one side of a membrane to the other, in a sodium dependent manner." [GOC:go_curators]
is_a: GO:0008514 ! organic anion transmembrane transporter activity

[Term]
id: GO:0043251
name: sodium-dependent organic anion transport
namespace: biological_process
def: "The directed, sodium-dependent, movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators]
is_a: GO:0015711 ! organic anion transport

[Term]
id: GO:0043252
name: sodium-independent organic anion transport
namespace: biological_process
def: "The directed, sodium-independent, movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators]
xref: Reactome:REACT_102139 "Transport of organic anions, Sus scrofa"
xref: Reactome:REACT_105237 "Transport of organic anions, Rattus norvegicus"
xref: Reactome:REACT_106076 "Transport of organic anions, Bos taurus"
xref: Reactome:REACT_113843 "Transport of organic anions, Danio rerio"
xref: Reactome:REACT_23988 "Transport of organic anions, Homo sapiens"
xref: Reactome:REACT_34433 "Transport of organic anions, Mus musculus"
xref: Reactome:REACT_80749 "Transport of organic anions, Xenopus tropicalis"
xref: Reactome:REACT_88721 "Transport of organic anions, Canis familiaris"
xref: Reactome:REACT_97219 "Transport of organic anions, Taeniopygia guttata"
is_a: GO:0015711 ! organic anion transport

[Term]
id: GO:0043253
name: chloroplast ribosome
namespace: cellular_component
def: "A ribosome contained within a chloroplast." [GOC:ecd]
is_a: GO:0009547 ! plastid ribosome
is_a: GO:0044434 ! chloroplast part
intersection_of: GO:0005840 ! ribosome
intersection_of: part_of GO:0009507 ! chloroplast
relationship: part_of GO:0009507 ! chloroplast
relationship: part_of GO:0009570 ! chloroplast stroma

[Term]
id: GO:0043254
name: regulation of protein complex assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein complex assembly." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006461 ! protein complex assembly
relationship: regulates GO:0006461 ! protein complex assembly

[Term]
id: GO:0043255
name: regulation of carbohydrate biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of carbohydrates." [GOC:jl]
subset: gosubset_prok
synonym: "regulation of carbohydrate anabolism" EXACT []
synonym: "regulation of carbohydrate biosynthesis" EXACT []
synonym: "regulation of carbohydrate formation" EXACT []
synonym: "regulation of carbohydrate synthesis" EXACT []
is_a: GO:0006109 ! regulation of carbohydrate metabolic process
is_a: GO:0009889 ! regulation of biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016051 ! carbohydrate biosynthetic process
relationship: regulates GO:0016051 ! carbohydrate biosynthetic process

[Term]
id: GO:0043256
name: laminin complex
namespace: cellular_component
def: "A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha, beta and gamma. Provides an integral part of the structural scaffolding of basement membranes." [GOC:jl, http://www.sdbonline.org/fly/newgene/laminna1.htm, PMID:10842354]
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044420 ! extracellular matrix component
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005605 ! basal lamina

[Term]
id: GO:0043257
name: laminin-8 complex
namespace: cellular_component
def: "A laminin complex composed of alpha4, beta1 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354]
is_a: GO:0043256 ! laminin complex

[Term]
id: GO:0043258
name: laminin-9 complex
namespace: cellular_component
def: "A laminin complex composed of alpha4, beta2 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354]
is_a: GO:0043256 ! laminin complex

[Term]
id: GO:0043259
name: laminin-10 complex
namespace: cellular_component
def: "A laminin complex composed of alpha5, beta1 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354]
is_a: GO:0043256 ! laminin complex

[Term]
id: GO:0043260
name: laminin-11 complex
namespace: cellular_component
def: "A laminin complex composed of alpha5, beta2 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354]
is_a: GO:0043256 ! laminin complex

[Term]
id: GO:0043261
name: laminin-12 complex
namespace: cellular_component
def: "A laminin complex composed of alpha2, beta1 and gamma3 polypeptide chains." [GOC:jl, PMID:10842354]
is_a: GO:0043256 ! laminin complex

[Term]
id: GO:0043262
name: adenosine-diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: ADP + H2O = AMP + phosphate." [EC:3.6.1.5, PMID:1470606]
synonym: "adenosine diphosphatase activity" EXACT []
synonym: "adenosinepyrophosphatase activity" EXACT [EC:3.6.1.6]
synonym: "ADPase" BROAD [EC:3.6.1.3]
synonym: "ADPase activity" EXACT [EC:3.6.1.6]
synonym: "ATP diphosphohydrolase" BROAD [EC:3.6.1.3]
synonym: "ATP diphosphohydrolase (phosphate-forming) activity" EXACT [EC:3.6.1.3]
synonym: "ATP-diphosphatase activity" EXACT [EC:3.6.1.3]
synonym: "ATP-diphosphohydrolase activity" EXACT [EC:3.6.1.3]
xref: MetaCyc:APYRASE-RXN
is_a: GO:0017110 ! nucleoside-diphosphatase activity

[Term]
id: GO:0043263
name: cellulosome
namespace: cellular_component
def: "An extracellular multi-enzyme complex containing up to 11 different enzymes aligned on a non-catalytic scaffolding glycoprotein. Functions to hydrolyze cellulose." [GOC:jl, PMID:11601609]
subset: gosubset_prok
xref: Wikipedia:Cellulosome
is_a: GO:0043264 ! extracellular non-membrane-bounded organelle

[Term]
id: GO:0043264
name: extracellular non-membrane-bounded organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:jl]
subset: gosubset_prok
synonym: "extracellular non-membrane-enclosed organelle" EXACT []
is_a: GO:0043228 ! non-membrane-bounded organelle
is_a: GO:0043230 ! extracellular organelle

[Term]
id: GO:0043265
name: ectoplasm
namespace: cellular_component
def: "Granule free cytoplasm, lying immediately below the plasma membrane." [GOC:curators, PMID:12211103]
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0043266
name: regulation of potassium ion transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]
synonym: "regulation of K+ conductance" NARROW []
synonym: "regulation of K+ transport" EXACT []
synonym: "regulation of potassium conductance" NARROW []
synonym: "regulation of potassium ion conductance" NARROW []
synonym: "regulation of potassium transport" EXACT []
is_a: GO:0010959 ! regulation of metal ion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006813 ! potassium ion transport
relationship: regulates GO:0006813 ! potassium ion transport

[Term]
id: GO:0043267
name: negative regulation of potassium ion transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]
synonym: "down regulation of potassium ion transport" EXACT []
synonym: "down-regulation of potassium ion transport" EXACT []
synonym: "downregulation of potassium ion transport" EXACT []
synonym: "inhibition of potassium ion transport" NARROW []
synonym: "negative regulation of K+ transport" EXACT []
synonym: "negative regulation of potassium ion conductance" NARROW []
synonym: "negative regulation of potassium transport" EXACT []
synonym: "regulation of K+ conductance" NARROW []
synonym: "regulation of potassium conductance" NARROW []
synonym: "transmembrane conductance regulator activity" RELATED []
is_a: GO:0043266 ! regulation of potassium ion transport
is_a: GO:0043271 ! negative regulation of ion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006813 ! potassium ion transport
relationship: negatively_regulates GO:0006813 ! potassium ion transport

[Term]
id: GO:0043268
name: positive regulation of potassium ion transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]
synonym: "activation of potassium ion transport" NARROW []
synonym: "positive regulation of K+ conductance" NARROW []
synonym: "positive regulation of K+ transport" EXACT []
synonym: "positive regulation of potassium conductance" NARROW []
synonym: "positive regulation of potassium ion conductance" NARROW []
synonym: "positive regulation of potassium transport" EXACT []
synonym: "stimulation of potassium ion transport" NARROW []
synonym: "up regulation of potassium ion transport" EXACT []
synonym: "up-regulation of potassium ion transport" EXACT []
synonym: "upregulation of potassium ion transport" EXACT []
is_a: GO:0043266 ! regulation of potassium ion transport
is_a: GO:0043270 ! positive regulation of ion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006813 ! potassium ion transport
relationship: positively_regulates GO:0006813 ! potassium ion transport

[Term]
id: GO:0043269
name: regulation of ion transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006811 ! ion transport
relationship: regulates GO:0006811 ! ion transport

[Term]
id: GO:0043270
name: positive regulation of ion transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]
synonym: "activation of ion transport" NARROW []
synonym: "stimulation of ion transport" NARROW []
synonym: "up regulation of ion transport" EXACT []
synonym: "up-regulation of ion transport" EXACT []
synonym: "upregulation of ion transport" EXACT []
is_a: GO:0043269 ! regulation of ion transport
is_a: GO:0051050 ! positive regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006811 ! ion transport
relationship: positively_regulates GO:0006811 ! ion transport

[Term]
id: GO:0043271
name: negative regulation of ion transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]
synonym: "down regulation of ion transport" EXACT []
synonym: "down-regulation of ion transport" EXACT []
synonym: "downregulation of ion transport" EXACT []
synonym: "inhibition of ion transport" NARROW []
is_a: GO:0043269 ! regulation of ion transport
is_a: GO:0051051 ! negative regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006811 ! ion transport
relationship: negatively_regulates GO:0006811 ! ion transport

[Term]
id: GO:0043272
name: ethylene biosynthesis involved in jasmonic acid and ethylene-dependent systemic resistance
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ethylene (C2-H4, ethene), occurring as part of the process of jasmonic acid and ethylene-dependent systemic resistance." [GOC:jl]
synonym: "ethylene anabolism during jasmonic acid and ethylene-dependent systemic resistance" RELATED []
synonym: "ethylene biosynthetic process during jasmonic acid and ethylene-dependent systemic resistance" RELATED [GOC:dph, GOC:tb]
synonym: "ethylene formation during jasmonic acid and ethylene-dependent systemic resistance" RELATED []
synonym: "ethylene synthesis during jasmonic acid and ethylene-dependent systemic resistance" RELATED []
is_a: GO:0009693 ! ethylene biosynthetic process
intersection_of: GO:0009693 ! ethylene biosynthetic process
intersection_of: part_of GO:0009861 ! jasmonic acid and ethylene-dependent systemic resistance
relationship: part_of GO:0009861 ! jasmonic acid and ethylene-dependent systemic resistance

[Term]
id: GO:0043273
name: CTPase activity
namespace: molecular_function
def: "Catalysis of the reaction: CTP + H2O = CDP + phosphate. May or may not be coupled to another reaction." [GOC:go_curators]
synonym: "cytidine triphosphatase activity" EXACT []
is_a: GO:0017111 ! nucleoside-triphosphatase activity

[Term]
id: GO:0043274
name: phospholipase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any phospholipase, enzymes that catalyze of the hydrolysis of a glycerophospholipid." [GOC:jl]
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0043275
name: obsolete glutamate carboxypeptidase II activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: N-acetyl-L-Asp-L-Glu + H2O = N-acetyl-L-Asp + L-Glu." [BRENDA:3.4.17.21, GOC:jl]
comment: This term was made obsolete because it represents a gene product.
synonym: "acetylaspartylglutamate dipeptidase activity" EXACT []
synonym: "folate hydrolase activity" RELATED [EC:3.4.17.21]
synonym: "folylpolyglutamate hydrolase activity" EXACT [EC:3.4.17.21]
synonym: "glutamate carboxypeptidase II activity" EXACT []
synonym: "membrane glutamate carboxypeptidase" NARROW [EC:3.4.17.21]
synonym: "mGCP" RELATED [EC:3.4.17.21]
synonym: "microsomal gamma-glutamyl carboxypeptidase" NARROW [EC:3.4.17.21]
synonym: "N-acetylated alpha-linked acidic dipeptidase activity" EXACT [EC:3.4.17.21]
synonym: "N-acetylated-alpha-linked-amino dipeptidase activity" EXACT [EC:3.4.17.21]
synonym: "N-acetylated-gamma-linked-acidic dipeptidase (NAALADase)" EXACT [EC:3.4.17.21]
synonym: "N-acetylated-gamma-linked-acidic dipeptidase activity" EXACT [EC:3.4.17.21]
synonym: "NAALA dipeptidase activity" EXACT [EC:3.4.17.21]
synonym: "NAALADase activity" EXACT [EC:3.4.17.21]
synonym: "prostate-specific membrane antigen" RELATED [EC:3.4.17.21]
synonym: "prostrate-specific membrane antigen" RELATED [EC:3.4.17.21]
synonym: "PSM antigen" RELATED [EC:3.4.17.21]
synonym: "PSMA" RELATED [EC:3.4.17.21]
synonym: "pteroylpoly-gamma-glutamate carboxypeptidase activity" EXACT [EC:3.4.17.21]
synonym: "pteroylpoly-gamma-glutamate hydrolase activity" EXACT [EC:3.4.17.21]
synonym: "pteroylpolygammaglutamyl hydrolase activity" EXACT [EC:3.4.17.21]
synonym: "pteroylpolyglutamate hydrolase activity" EXACT [EC:3.4.17.21]
synonym: "pteroylpolyglutamic acid hydrolase activity" EXACT [EC:3.4.17.21]
synonym: "rat NAAG peptidase" NARROW [EC:3.4.17.21]
xref: EC:3.4.17.21
is_obsolete: true
replaced_by: GO:0004181

[Term]
id: GO:0043276
name: anoikis
namespace: biological_process
def: "Apoptosis triggered by inadequate or inappropriate adherence to substrate e.g. after disruption of the interactions between normal epithelial cells and the extracellular matrix." [GOC:jl, http://www.copewithcytokines.de/]
synonym: "detachment induced cell death" EXACT []
synonym: "suspension induced apoptosis" EXACT []
xref: Wikipedia:Anoikis
is_a: GO:0006915 ! apoptotic process

[Term]
id: GO:0043277
name: apoptotic cell clearance
namespace: biological_process
def: "The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte." [GOC:rk, PMID:14685684]
comment: Note that unlike mammals or Drosophila, C. elegans (and many lower organisms) do not have professional macrophages/phagocytes, instead cell corpses are engulfed by neighboring cells. Cell types that can function as engulfing cells include hypodermal cells, gonadal sheath cells, pharyngeal muscle cells, and intestinal cells.
synonym: "apoptotic cell removal" EXACT []
synonym: "efferocytosis" EXACT [PMID:17548650]
synonym: "programmed cell clearance" EXACT []
is_a: GO:0006909 ! phagocytosis

[Term]
id: GO:0043278
name: response to morphine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure." [CHEBI:17303, GOC:ef, GOC:jl]
is_a: GO:0014072 ! response to isoquinoline alkaloid

[Term]
id: GO:0043279
name: response to alkaloid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active." [CHEBI:22315, GOC:jl]
is_a: GO:0010243 ! response to organonitrogen compound

[Term]
id: GO:0043280
name: positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
namespace: biological_process
def: "Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
synonym: "activation of caspase activity" NARROW []
synonym: "positive regulation of caspase activity" BROAD []
synonym: "stimulation of caspase activity" NARROW []
synonym: "up regulation of caspase activity" EXACT []
synonym: "up-regulation of caspase activity" EXACT []
synonym: "upregulation of caspase activity" EXACT []
is_a: GO:0043065 ! positive regulation of apoptotic process
is_a: GO:0043281 ! regulation of cysteine-type endopeptidase activity involved in apoptotic process
is_a: GO:2001056 ! positive regulation of cysteine-type endopeptidase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097153 ! cysteine-type endopeptidase activity involved in apoptotic process
relationship: part_of GO:0006915 ! apoptotic process
relationship: positively_regulates GO:0097153 ! cysteine-type endopeptidase activity involved in apoptotic process

[Term]
id: GO:0043281
name: regulation of cysteine-type endopeptidase activity involved in apoptotic process
namespace: biological_process
alt_id: GO:0043026
def: "Any process that modulates the activity of a cysteine-type endopeptidase involved in apoptosis." [GOC:jl, GOC:mtg_apoptosis]
synonym: "regulation of caspase activation" NARROW []
synonym: "regulation of caspase activity" BROAD []
is_a: GO:0042981 ! regulation of apoptotic process
is_a: GO:2000116 ! regulation of cysteine-type endopeptidase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097153 ! cysteine-type endopeptidase activity involved in apoptotic process
relationship: part_of GO:0006915 ! apoptotic process
relationship: regulates GO:0097153 ! cysteine-type endopeptidase activity involved in apoptotic process

[Term]
id: GO:0043282
name: pharyngeal muscle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pharyngeal muscle over time, from its formation to the mature structure. A pharyngeal muscle is any muscle that forms part of the pharynx." [GOC:go_curators]
is_a: GO:0007517 ! muscle organ development
relationship: part_of GO:0060465 ! pharynx development

[Term]
id: GO:0043286
name: regulation of poly(3-hydroxyalkanoate) biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of poly(3-hydroxyalkanoates), polyesters of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria." [GOC:jl]
subset: gosubset_prok
synonym: "regulation of PHA" EXACT []
synonym: "regulation of poly(3-hydroxyalkanoate) anabolism" EXACT []
synonym: "regulation of poly(3-hydroxyalkanoate) biosynthesis" EXACT []
synonym: "regulation of poly(3-hydroxyalkanoate) formation" EXACT []
synonym: "regulation of poly(3-hydroxyalkanoate) synthesis" EXACT []
is_a: GO:0009889 ! regulation of biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042621 ! poly(3-hydroxyalkanoate) biosynthetic process
relationship: regulates GO:0042621 ! poly(3-hydroxyalkanoate) biosynthetic process

[Term]
id: GO:0043287
name: poly(3-hydroxyalkanoate) binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with poly(3-hydroxyalkanoate)s, polyesters of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria." [GOC:jl]
subset: gosubset_prok
synonym: "PHA binding" EXACT []
is_a: GO:0005488 ! binding

[Term]
id: GO:0043288
name: apocarotenoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving apocarotenoids, a class of compounds derived from the oxidative cleavage of carotenoids, many of which are biologically important e.g. retinal and abscisic acid." [GOC:jl, http://www.msu.edu/~schwart1/apocarotenoids.htm]
subset: gosubset_prok
synonym: "apo carotenoid metabolic process" EXACT [CHEBI:53183]
synonym: "apocarotenoid metabolism" EXACT []
is_a: GO:0006720 ! isoprenoid metabolic process

[Term]
id: GO:0043289
name: apocarotenoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of apocarotenoids by the oxidative cleavage of carotenoids. Many apocarotenoids are biologically important e.g. retinal and abscisic acid." [GOC:jl, http://www.msu.edu/~schwart1/apocarotenoids.htm]
subset: gosubset_prok
synonym: "apo carotenoid biosynthetic process" EXACT [CHEBI:53183]
synonym: "apocarotenoid anabolism" EXACT []
synonym: "apocarotenoid biosynthesis" EXACT []
synonym: "apocarotenoid formation" EXACT []
synonym: "apocarotenoid synthesis" EXACT []
is_a: GO:0008299 ! isoprenoid biosynthetic process
is_a: GO:0043288 ! apocarotenoid metabolic process

[Term]
id: GO:0043290
name: apocarotenoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of apocarotenoids, a class of compounds derived from the oxidative cleavage of carotenoids, many of which are biologically important e.g. retinal and abscisic acid." [GOC:jl, http://www.msu.edu/~schwart1/apocarotenoids.htm]
subset: gosubset_prok
synonym: "apo carotenoid catabolic process" EXACT [CHEBI:53183]
synonym: "apocarotenoid breakdown" EXACT []
synonym: "apocarotenoid catabolism" EXACT []
synonym: "apocarotenoid degradation" EXACT []
is_a: GO:0008300 ! isoprenoid catabolic process
is_a: GO:0043288 ! apocarotenoid metabolic process

[Term]
id: GO:0043291
name: RAVE complex
namespace: cellular_component
def: "A multisubunit complex that in Saccharomyces is composed of three subunits, Rav1p, Rav2p and Skp1p. Acts transiently to catalyze assembly of cytoplasmic V1, with membrane embedded V0 to form the V-ATPase holoenzyme." [PMID:11283612, PMID:11844802]
synonym: "regulator of the (H+)-ATPase of the vacuolar and endosomal membranes" BROAD []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0043292
name: contractile fiber
namespace: cellular_component
def: "Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle." [GOC:go_curators, ISBN:0815316194]
synonym: "contractile fibre" EXACT []
synonym: "muscle fiber" BROAD []
synonym: "muscle fibre" BROAD []
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0043293
name: apoptosome
namespace: cellular_component
def: "A multisubunit protein complex involved in the signaling phase of the apoptotic process. In mammals it is typically composed of seven Apaf-1 subunits bound to cytochrome c and caspase-9. A similar complex to promote apoptosis is formed from homologous gene products in other eukaryotic organisms." [GOC:mtg_apoptosis, PMID:10428850, PMID:11406413, PMID:12176339, PMID:15189137]
xref: Wikipedia:Apoptosome
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0043294
name: mitochondrial glutamate synthase complex (NADH)
namespace: cellular_component
def: "A protein complex, found in the mitochondria, that in yeast consists of a large and a small subunit. Possesses glutamate synthase (NADH) activity." [GOC:jl, PMID:7047525]
is_a: GO:0031027 ! glutamate synthase complex (NADH)
is_a: GO:0098798 ! mitochondrial protein complex
intersection_of: GO:0031027 ! glutamate synthase complex (NADH)
intersection_of: part_of GO:0005739 ! mitochondrion
relationship: part_of GO:0005739 ! mitochondrion
relationship: part_of GO:0005759 ! mitochondrial matrix

[Term]
id: GO:0043295
name: glutathione binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine." [GOC:bf, ISBN:0198506732]
is_a: GO:0043168 ! anion binding
is_a: GO:0072341 ! modified amino acid binding
is_a: GO:1900750 ! oligopeptide binding
is_a: GO:1901681 ! sulfur compound binding

[Term]
id: GO:0043296
name: apical junction complex
namespace: cellular_component
def: "A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in some invertebrates, such as Drosophila, is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability." [GOC:go_curators, GOC:kmv, PMID:12525486, PMID:15196556]
synonym: "apical cell junction complex" EXACT [GOC:mah]
synonym: "apical junction" EXACT []
is_a: GO:0005911 ! cell-cell junction

[Term]
id: GO:0043297
name: apical junction assembly
namespace: biological_process
def: "The formation of an apical junction, a functional unit located near the cell apex at the points of contact between epithelial cells composed of the tight junction, the zonula adherens junction and the desmosomes, by the aggregation, arrangement and bonding together of its constituents." [GOC:go_curators, PMID:10854689, PMID:14729475, PMID:15196556]
synonym: "apical junction complex assembly" EXACT [GOC:mah]
is_a: GO:0007043 ! cell-cell junction assembly

[Term]
id: GO:0043299
name: leukocyte degranulation
namespace: biological_process
def: "The regulated exocytosis of secretory granules by a leukocyte." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was improved by GO_REF:0000022. It was moved.
synonym: "immune cell degranulation" EXACT []
synonym: "immune cell granule exocytosis" EXACT []
synonym: "leucocyte degranulation" EXACT []
synonym: "leukocyte granule exocytosis" EXACT []
is_a: GO:0002252 ! immune effector process
is_a: GO:0045055 ! regulated exocytosis

[Term]
id: GO:0043300
name: regulation of leukocyte degranulation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of leukocyte degranulation." [GOC:add, ISBN:0781735149]
synonym: "regulation of immune cell degranulation" EXACT []
synonym: "regulation of immune cell granule exocytosis" EXACT []
synonym: "regulation of leucocyte degranulation" EXACT []
synonym: "regulation of leukocyte granule exocytosis" EXACT []
is_a: GO:0002697 ! regulation of immune effector process
is_a: GO:1903305 ! regulation of regulated secretory pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043299 ! leukocyte degranulation
relationship: regulates GO:0043299 ! leukocyte degranulation

[Term]
id: GO:0043301
name: negative regulation of leukocyte degranulation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of leukocyte degranulation." [GOC:add, ISBN:0781735149]
synonym: "down regulation of leukocyte degranulation" EXACT []
synonym: "down-regulation of leukocyte degranulation" EXACT []
synonym: "downregulation of leukocyte degranulation" EXACT []
synonym: "inhibition of leukocyte degranulation" NARROW []
synonym: "negative regulation of immune cell degranulation" EXACT []
synonym: "negative regulation of leucocyte degranulation" EXACT []
is_a: GO:0002698 ! negative regulation of immune effector process
is_a: GO:0043300 ! regulation of leukocyte degranulation
is_a: GO:1903306 ! negative regulation of regulated secretory pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043299 ! leukocyte degranulation
relationship: negatively_regulates GO:0043299 ! leukocyte degranulation

[Term]
id: GO:0043302
name: positive regulation of leukocyte degranulation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of leukocyte degranulation." [GOC:add, ISBN:0781735149]
synonym: "activation of leukocyte degranulation" NARROW []
synonym: "positive regulation of immune cell degranulation" EXACT []
synonym: "positive regulation of leucocyte degranulation" EXACT []
synonym: "stimulation of leukocyte degranulation" NARROW []
synonym: "up regulation of leukocyte degranulation" EXACT []
synonym: "up-regulation of leukocyte degranulation" EXACT []
synonym: "upregulation of leukocyte degranulation" EXACT []
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0043300 ! regulation of leukocyte degranulation
is_a: GO:1903307 ! positive regulation of regulated secretory pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043299 ! leukocyte degranulation
relationship: positively_regulates GO:0043299 ! leukocyte degranulation

[Term]
id: GO:0043303
name: mast cell degranulation
namespace: biological_process
def: "The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell." [ISBN:0781735149]
synonym: "mast cell granule exocytosis" EXACT []
is_a: GO:0002279 ! mast cell activation involved in immune response
is_a: GO:0032418 ! lysosome localization
is_a: GO:0043299 ! leukocyte degranulation
is_a: GO:0051656 ! establishment of organelle localization
is_a: GO:1902580 ! single-organism cellular localization
is_a: GO:1902582 ! single-organism intracellular transport
relationship: occurs_in GO:0042629 ! mast cell granule
relationship: part_of GO:0002448 ! mast cell mediated immunity

[Term]
id: GO:0043304
name: regulation of mast cell degranulation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of mast cell degranulation." [ISBN:0781735149]
synonym: "regulation of mast cell granule exocytosis" EXACT []
is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity
is_a: GO:0032386 ! regulation of intracellular transport
is_a: GO:0033006 ! regulation of mast cell activation involved in immune response
is_a: GO:0043300 ! regulation of leukocyte degranulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043303 ! mast cell degranulation
relationship: regulates GO:0043303 ! mast cell degranulation

[Term]
id: GO:0043305
name: negative regulation of mast cell degranulation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of mast cell degranulation." [ISBN:0781735149]
synonym: "down regulation of mast cell degranulation" EXACT []
synonym: "down-regulation of mast cell degranulation" EXACT []
synonym: "downregulation of mast cell degranulation" EXACT []
synonym: "inhibition of mast cell degranulation" NARROW []
synonym: "negative regulation of mast cell granule exocytosis" EXACT []
is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity
is_a: GO:0032387 ! negative regulation of intracellular transport
is_a: GO:0033007 ! negative regulation of mast cell activation involved in immune response
is_a: GO:0043301 ! negative regulation of leukocyte degranulation
is_a: GO:0043304 ! regulation of mast cell degranulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043303 ! mast cell degranulation
relationship: negatively_regulates GO:0043303 ! mast cell degranulation

[Term]
id: GO:0043306
name: positive regulation of mast cell degranulation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mast cell degranulation." [ISBN:0781735149]
synonym: "activation of mast cell degranulation" NARROW []
synonym: "positive regulation of mast cell granule exocytosis" EXACT []
synonym: "stimulation of mast cell degranulation" NARROW []
synonym: "up regulation of mast cell degranulation" EXACT []
synonym: "up-regulation of mast cell degranulation" EXACT []
synonym: "upregulation of mast cell degranulation" EXACT []
is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity
is_a: GO:0032388 ! positive regulation of intracellular transport
is_a: GO:0033008 ! positive regulation of mast cell activation involved in immune response
is_a: GO:0043302 ! positive regulation of leukocyte degranulation
is_a: GO:0043304 ! regulation of mast cell degranulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043303 ! mast cell degranulation
relationship: positively_regulates GO:0043303 ! mast cell degranulation

[Term]
id: GO:0043307
name: eosinophil activation
namespace: biological_process
def: "The change in morphology and behavior of a eosinophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:add, ISBN:0781735149]
is_a: GO:0036230 ! granulocyte activation

[Term]
id: GO:0043308
name: eosinophil degranulation
namespace: biological_process
def: "The regulated exocytosis of secretory granules containing preformed mediators such as major basic protein, eosinophil peroxidase, and eosinophil cationic protein by an eosinophil." [ISBN:0781735149]
synonym: "eosinophil granule exocytosis" EXACT []
is_a: GO:0002278 ! eosinophil activation involved in immune response
is_a: GO:0043299 ! leukocyte degranulation
relationship: part_of GO:0002447 ! eosinophil mediated immunity

[Term]
id: GO:0043309
name: regulation of eosinophil degranulation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of eosinophil degranulation." [ISBN:0781735149]
synonym: "regulation of eosinophil granule exocytosis" EXACT []
is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity
is_a: GO:0043300 ! regulation of leukocyte degranulation
is_a: GO:0050776 ! regulation of immune response
is_a: GO:1902566 ! regulation of eosinophil activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043308 ! eosinophil degranulation
relationship: regulates GO:0043308 ! eosinophil degranulation

[Term]
id: GO:0043310
name: negative regulation of eosinophil degranulation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of eosinophil degranulation." [ISBN:0781735149]
synonym: "down regulation of eosinophil degranulation" EXACT []
synonym: "down-regulation of eosinophil degranulation" EXACT []
synonym: "downregulation of eosinophil degranulation" EXACT []
synonym: "inhibition of eosinophil degranulation" NARROW []
synonym: "negative regulation of eosinophil granule exocytosis" EXACT []
is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity
is_a: GO:0043301 ! negative regulation of leukocyte degranulation
is_a: GO:0043309 ! regulation of eosinophil degranulation
is_a: GO:0050777 ! negative regulation of immune response
is_a: GO:1902567 ! negative regulation of eosinophil activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043308 ! eosinophil degranulation
relationship: negatively_regulates GO:0043308 ! eosinophil degranulation

[Term]
id: GO:0043311
name: positive regulation of eosinophil degranulation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of eosinophil degranulation." [ISBN:0781735149]
synonym: "activation of eosinophil degranulation" NARROW []
synonym: "positive regulation of eosinophil granule exocytosis" EXACT []
synonym: "stimulation of eosinophil degranulation" NARROW []
synonym: "up regulation of eosinophil degranulation" EXACT []
synonym: "up-regulation of eosinophil degranulation" EXACT []
synonym: "upregulation of eosinophil degranulation" EXACT []
is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity
is_a: GO:0043302 ! positive regulation of leukocyte degranulation
is_a: GO:0043309 ! regulation of eosinophil degranulation
is_a: GO:0050778 ! positive regulation of immune response
is_a: GO:1902568 ! positive regulation of eosinophil activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043308 ! eosinophil degranulation
relationship: positively_regulates GO:0043308 ! eosinophil degranulation

[Term]
id: GO:0043312
name: neutrophil degranulation
namespace: biological_process
def: "The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil." [ISBN:0781735149]
synonym: "heterophil degranulation" RELATED []
synonym: "neutrophil granule exocytosis" EXACT []
is_a: GO:0002283 ! neutrophil activation involved in immune response
is_a: GO:0043299 ! leukocyte degranulation
relationship: part_of GO:0002446 ! neutrophil mediated immunity

[Term]
id: GO:0043313
name: regulation of neutrophil degranulation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of neutrophil degranulation." [ISBN:0781735149]
synonym: "regulation of neutrophil granule exocytosis" EXACT []
is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity
is_a: GO:0043300 ! regulation of leukocyte degranulation
is_a: GO:0050776 ! regulation of immune response
is_a: GO:1902563 ! regulation of neutrophil activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043312 ! neutrophil degranulation
relationship: regulates GO:0043312 ! neutrophil degranulation

[Term]
id: GO:0043314
name: negative regulation of neutrophil degranulation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of neutrophil degranulation." [ISBN:0781735149]
synonym: "down regulation of neutrophil degranulation" EXACT []
synonym: "down-regulation of neutrophil degranulation" EXACT []
synonym: "downregulation of neutrophil degranulation" EXACT []
synonym: "inhibition of neutrophil degranulation" NARROW []
synonym: "negative regulation of neutrophil granule exocytosis" EXACT []
is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity
is_a: GO:0043301 ! negative regulation of leukocyte degranulation
is_a: GO:0043313 ! regulation of neutrophil degranulation
is_a: GO:0050777 ! negative regulation of immune response
is_a: GO:1902564 ! negative regulation of neutrophil activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043312 ! neutrophil degranulation
relationship: negatively_regulates GO:0043312 ! neutrophil degranulation

[Term]
id: GO:0043315
name: positive regulation of neutrophil degranulation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neutrophil degranulation." [ISBN:0781735149]
synonym: "activation of neutrophil degranulation" NARROW []
synonym: "positive regulation of neutrophil granule exocytosis" EXACT []
synonym: "stimulation of neutrophil degranulation" NARROW []
synonym: "up regulation of neutrophil degranulation" EXACT []
synonym: "up-regulation of neutrophil degranulation" EXACT []
synonym: "upregulation of neutrophil degranulation" EXACT []
is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity
is_a: GO:0043302 ! positive regulation of leukocyte degranulation
is_a: GO:0043313 ! regulation of neutrophil degranulation
is_a: GO:0050778 ! positive regulation of immune response
is_a: GO:1902565 ! positive regulation of neutrophil activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043312 ! neutrophil degranulation
relationship: positively_regulates GO:0043312 ! neutrophil degranulation

[Term]
id: GO:0043316
name: cytotoxic T cell degranulation
namespace: biological_process
def: "The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a cytotoxic T cell." [ISBN:0781735149]
synonym: "cytotoxic T cell granule exocytosis" EXACT []
synonym: "cytotoxic T lymphocyte degranulation" EXACT []
synonym: "cytotoxic T lymphocyte granule exocytosis" EXACT []
synonym: "cytotoxic T-cell degranulation" EXACT []
synonym: "cytotoxic T-cell granule exocytosis" EXACT []
synonym: "cytotoxic T-lymphocyte degranulation" EXACT []
synonym: "cytotoxic T-lymphocyte granule exocytosis" EXACT []
is_a: GO:0002286 ! T cell activation involved in immune response
is_a: GO:0043299 ! leukocyte degranulation
relationship: part_of GO:0001913 ! T cell mediated cytotoxicity

[Term]
id: GO:0043317
name: regulation of cytotoxic T cell degranulation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of cytotoxic T cell degranulation." [ISBN:0781735149]
synonym: "regulation of cytotoxic T cell granule exocytosis" EXACT []
synonym: "regulation of cytotoxic T lymphocyte degranulation" EXACT []
synonym: "regulation of cytotoxic T lymphocyte granule exocytosis" EXACT []
synonym: "regulation of cytotoxic T-cell degranulation" EXACT []
synonym: "regulation of cytotoxic T-cell granule exocytosis" EXACT []
synonym: "regulation of cytotoxic T-lymphocyte degranulation" EXACT []
synonym: "regulation of cytotoxic T-lymphocyte granule exocytosis" EXACT []
is_a: GO:0001914 ! regulation of T cell mediated cytotoxicity
is_a: GO:0043300 ! regulation of leukocyte degranulation
is_a: GO:0050863 ! regulation of T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043316 ! cytotoxic T cell degranulation
relationship: regulates GO:0043316 ! cytotoxic T cell degranulation

[Term]
id: GO:0043318
name: negative regulation of cytotoxic T cell degranulation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of cytotoxic T cell degranulation." [ISBN:0781735149]
synonym: "down regulation of cytotoxic T cell degranulation" EXACT []
synonym: "down-regulation of cytotoxic T cell degranulation" EXACT []
synonym: "downregulation of cytotoxic T cell degranulation" EXACT []
synonym: "inhibition of cytotoxic T cell degranulation" NARROW []
synonym: "negative regulation of cytotoxic T cell granule exocytosis" EXACT []
synonym: "negative regulation of cytotoxic T lymphocyte degranulation" EXACT []
synonym: "negative regulation of cytotoxic T lymphocyte granule exocytosis" EXACT []
synonym: "negative regulation of cytotoxic T-cell degranulation" EXACT []
synonym: "negative regulation of cytotoxic T-cell granule exocytosis" EXACT []
synonym: "negative regulation of cytotoxic T-lymphocyte degranulation" EXACT []
synonym: "negative regulation of cytotoxic T-lymphocyte granule exocytosis" EXACT []
is_a: GO:0001915 ! negative regulation of T cell mediated cytotoxicity
is_a: GO:0043301 ! negative regulation of leukocyte degranulation
is_a: GO:0043317 ! regulation of cytotoxic T cell degranulation
is_a: GO:0050868 ! negative regulation of T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043316 ! cytotoxic T cell degranulation
relationship: negatively_regulates GO:0043316 ! cytotoxic T cell degranulation

[Term]
id: GO:0043319
name: positive regulation of cytotoxic T cell degranulation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cytotoxic T cell degranulation." [ISBN:0781735149]
synonym: "activation of cytotoxic T cell degranulation" NARROW []
synonym: "positive regulation of cytotoxic T cell granule exocytosis" EXACT []
synonym: "positive regulation of cytotoxic T lymphocyte degranulation" EXACT []
synonym: "positive regulation of cytotoxic T lymphocyte granule exocytosis" EXACT []
synonym: "positive regulation of cytotoxic T-cell degranulation" EXACT []
synonym: "positive regulation of cytotoxic T-cell granule exocytosis" EXACT []
synonym: "positive regulation of cytotoxic T-lymphocyte degranulation" EXACT []
synonym: "positive regulation of cytotoxic T-lymphocyte granule exocytosis" EXACT []
synonym: "stimulation of cytotoxic T cell degranulation" NARROW []
synonym: "up regulation of cytotoxic T cell degranulation" EXACT []
synonym: "up-regulation of cytotoxic T cell degranulation" EXACT []
synonym: "upregulation of cytotoxic T cell degranulation" EXACT []
is_a: GO:0001916 ! positive regulation of T cell mediated cytotoxicity
is_a: GO:0043302 ! positive regulation of leukocyte degranulation
is_a: GO:0043317 ! regulation of cytotoxic T cell degranulation
is_a: GO:0050870 ! positive regulation of T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043316 ! cytotoxic T cell degranulation
relationship: positively_regulates GO:0043316 ! cytotoxic T cell degranulation

[Term]
id: GO:0043320
name: natural killer cell degranulation
namespace: biological_process
def: "The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a natural killer cell." [ISBN:0781735149]
synonym: "natural killer cell granule exocytosis" EXACT []
synonym: "NK cell degranulation" EXACT []
synonym: "NK cell granule exocytosis" EXACT []
is_a: GO:0002323 ! natural killer cell activation involved in immune response
is_a: GO:0043299 ! leukocyte degranulation
relationship: part_of GO:0042267 ! natural killer cell mediated cytotoxicity

[Term]
id: GO:0043321
name: regulation of natural killer cell degranulation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of natural killer cell degranulation." [ISBN:0781735149]
synonym: "regulation of natural killer cell granule exocytosis" EXACT []
synonym: "regulation of NK cell degranulation" EXACT []
synonym: "regulation of NK cell granule exocytosis" EXACT []
is_a: GO:0032814 ! regulation of natural killer cell activation
is_a: GO:0042269 ! regulation of natural killer cell mediated cytotoxicity
is_a: GO:0043300 ! regulation of leukocyte degranulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043320 ! natural killer cell degranulation
relationship: regulates GO:0043320 ! natural killer cell degranulation

[Term]
id: GO:0043322
name: negative regulation of natural killer cell degranulation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of natural killer cell degranulation." [ISBN:0781735149]
synonym: "down regulation of natural killer cell degranulation" EXACT []
synonym: "down-regulation of natural killer cell degranulation" EXACT []
synonym: "downregulation of natural killer cell degranulation" EXACT []
synonym: "inhibition of natural killer cell degranulation" NARROW []
synonym: "negative regulation of natural killer cell granule exocytosis" EXACT []
synonym: "negative regulation of NK cell degranulation" EXACT []
synonym: "negative regulation of NK cell granule exocytosis" EXACT []
is_a: GO:0032815 ! negative regulation of natural killer cell activation
is_a: GO:0043301 ! negative regulation of leukocyte degranulation
is_a: GO:0043321 ! regulation of natural killer cell degranulation
is_a: GO:0045953 ! negative regulation of natural killer cell mediated cytotoxicity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043320 ! natural killer cell degranulation
relationship: negatively_regulates GO:0043320 ! natural killer cell degranulation

[Term]
id: GO:0043323
name: positive regulation of natural killer cell degranulation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of natural killer cell degranulation." [ISBN:0781735149]
synonym: "activation of natural killer cell degranulation" NARROW []
synonym: "positive regulation of natural killer cell granule exocytosis" EXACT []
synonym: "positive regulation of NK cell degranulation" EXACT []
synonym: "positive regulation of NK cell granule exocytosis" EXACT []
synonym: "stimulation of natural killer cell degranulation" NARROW []
synonym: "up regulation of natural killer cell degranulation" EXACT []
synonym: "up-regulation of natural killer cell degranulation" EXACT []
synonym: "upregulation of natural killer cell degranulation" EXACT []
is_a: GO:0032816 ! positive regulation of natural killer cell activation
is_a: GO:0043302 ! positive regulation of leukocyte degranulation
is_a: GO:0043321 ! regulation of natural killer cell degranulation
is_a: GO:0045954 ! positive regulation of natural killer cell mediated cytotoxicity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043320 ! natural killer cell degranulation
relationship: positively_regulates GO:0043320 ! natural killer cell degranulation

[Term]
id: GO:0043324
name: pigment metabolic process involved in developmental pigmentation
namespace: biological_process
def: "The chemical reactions and pathways involving biological pigments e.g. melanin, occurring as part of the development of an organ or organism." [GOC:jl, ISBN:0198506732]
synonym: "pigment metabolic process during developmental pigmentation" RELATED [GOC:dph, GOC:tb]
synonym: "pigment metabolism during developmental pigmentation" RELATED [GOC:dph, GOC:tb]
is_a: GO:0043474 ! pigment metabolic process involved in pigmentation
intersection_of: GO:0042440 ! pigment metabolic process
intersection_of: part_of GO:0048066 ! developmental pigmentation
relationship: part_of GO:0048066 ! developmental pigmentation

[Term]
id: GO:0043325
name: phosphatidylinositol-3,4-bisphosphate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with phosphatidylinositol-3,4-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 4' positions." [GOC:bf, GOC:go_curators]
is_a: GO:1902936 ! phosphatidylinositol bisphosphate binding

[Term]
id: GO:0043326
name: chemotaxis to folate
namespace: biological_process
def: "The directed movement of a motile cell or organism in response to the presence of folate." [GOC:go_curators]
is_a: GO:0006935 ! chemotaxis
is_a: GO:0051593 ! response to folic acid

[Term]
id: GO:0043327
name: chemotaxis to cAMP
namespace: biological_process
def: "The directed movement of a motile cell or organism in response to the presence of 3',5'-cAMP." [GOC:go_curators]
synonym: "chemotaxis to 3',5' cAMP" EXACT []
synonym: "chemotaxis to 3',5'-cAMP" EXACT []
synonym: "chemotaxis to adenosine 3',5'-cyclophosphate" EXACT []
synonym: "chemotaxis to cyclic AMP" EXACT []
is_a: GO:0006935 ! chemotaxis
is_a: GO:0051591 ! response to cAMP

[Term]
id: GO:0043328
name: protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
namespace: biological_process
def: "The process of directing proteins towards the vacuole using signals contained within the protein, occurring that contributes to protein catabolism via the multivesicular body (MVB) pathway." [GOC:jl, PMID:11511343]
synonym: "protein targeting to vacuole during ubiquitin-dependent protein breakdown via the MVB pathway" EXACT []
synonym: "protein targeting to vacuole during ubiquitin-dependent protein catabolic process via the MVB pathway" RELATED [GOC:dph, GOC:tb]
synonym: "protein targeting to vacuole during ubiquitin-dependent protein degradation via the MVB pathway" EXACT []
synonym: "protein vacuolar targeting during ubiquitin-dependent protein catabolic process via the MVB pathway" EXACT []
synonym: "protein vacuolar targeting during ubiquitin-dependent protein catabolism via the MVB pathway" EXACT []
synonym: "protein-vacuolar targeting during ubiquitin-dependent protein breakdown via the MVB pathway" EXACT []
synonym: "protein-vacuolar targeting during ubiquitin-dependent protein degradation via the MVB pathway" EXACT []
synonym: "protein-vacuole targeting during ubiquitin-dependent protein catabolic process via the MVB pathway" EXACT []
synonym: "protein-vacuole targeting during ubiquitin-dependent protein catabolism via the MVB pathway" EXACT []
is_a: GO:0006623 ! protein targeting to vacuole
is_a: GO:0032511 ! late endosome to vacuole transport via multivesicular body sorting pathway
intersection_of: GO:0006623 ! protein targeting to vacuole
intersection_of: part_of GO:0043162 ! ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
relationship: part_of GO:0043162 ! ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

[Term]
id: GO:0043329
name: protein targeting to membrane involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
namespace: biological_process
def: "The process of directing proteins towards a membrane using signals contained within the protein, occurring that contributes to ubiquitin-dependent protein catabolism via the MVB pathway; the destruction of a protein or peptide covalently tagged with a ubiquitin, via the multivesicular body (MVB) sorting pathway." [GOC:jl]
synonym: "protein membrane targeting during ubiquitin-dependent protein catabolic process via the MVB pathway" EXACT []
synonym: "protein membrane targeting during ubiquitin-dependent protein catabolism via the MVB pathway" EXACT []
synonym: "protein targeting to membrane during ubiquitin-dependent protein breakdown via the MVB pathway" EXACT []
synonym: "protein targeting to membrane during ubiquitin-dependent protein catabolic process via the MVB pathway" RELATED [GOC:dph, GOC:tb]
synonym: "protein targeting to membrane during ubiquitin-dependent protein degradation via the MVB pathway" EXACT []
synonym: "protein-membrane targeting during ubiquitin-dependent protein breakdown via the MVB pathway" EXACT []
synonym: "protein-membrane targeting during ubiquitin-dependent protein catabolic process via the MVB pathway" EXACT []
synonym: "protein-membrane targeting during ubiquitin-dependent protein catabolism via the MVB pathway" EXACT []
synonym: "protein-membrane targeting during ubiquitin-dependent protein degradation via the MVB pathway" EXACT []
is_a: GO:0006612 ! protein targeting to membrane
intersection_of: GO:0006612 ! protein targeting to membrane
intersection_of: part_of GO:0043162 ! ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
relationship: has_part GO:0071985 ! multivesicular body sorting pathway
relationship: part_of GO:0043162 ! ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

[Term]
id: GO:0043330
name: response to exogenous dsRNA
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus." [GOC:go_curators]
comment: Note that the presence of exogenous double-stranded RNA is usually indicative of a viral infection. Consider also annotating to 'response to virus ; GO:0009615'.
synonym: "response to exogenous double-stranded RNA" EXACT []
synonym: "response to viral dsRNA" NARROW []
is_a: GO:0043331 ! response to dsRNA

[Term]
id: GO:0043331
name: response to dsRNA
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded RNA stimulus." [GOC:jl]
synonym: "response to double-stranded RNA" EXACT []
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901698 ! response to nitrogen compound

[Term]
id: GO:0043332
name: mating projection tip
namespace: cellular_component
def: "The apex of the mating projection in unicellular fungi exposed to mating pheromone; site of polarized growth." [GOC:mcc]
synonym: "conjugation tube tip" NARROW []
synonym: "shmoo tip" NARROW []
is_a: GO:0030427 ! site of polarized growth
is_a: GO:0044463 ! cell projection part
intersection_of: GO:0030427 ! site of polarized growth
intersection_of: part_of GO:0005937 ! mating projection
relationship: part_of GO:0005937 ! mating projection

[Term]
id: GO:0043333
name: 2-octaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-octaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:kd, PMID:9045837]
comment: Note that the polyprenyl sidechain substrate for these methyltransferases varies in length between species, for example, 6 units in S. cerevisiae, 8 units in E. coli and 10 units in G. suboxidans. Where the length of the substrate polyprenyl chain is unknown, the term '2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity ; GO:0008425' should be used.
synonym: "2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity" EXACT []
is_a: GO:0008425 ! 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity

[Term]
id: GO:0043334
name: 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hexaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-hexaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:kd, PMID:9083048]
comment: Note that the polyprenyl sidechain substrate for these methyltransferases varies in length between species, for example, 6 units in S. cerevisiae, 8 units in E. coli and 10 units in G. suboxidans. Where the length of the substrate polyprenyl chain is unknown, the term '2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity ; GO:0008425' should be used.
synonym: "2-hexaprenyl-6-methoxy-1,4-benzoquinone methylase activity" EXACT []
is_a: GO:0008425 ! 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity

[Term]
id: GO:0043335
name: protein unfolding
namespace: biological_process
def: "The process of assisting in the disassembly of non-covalent linkages in a protein or protein aggregate, often where the proteins are in a non-functional or denatured state." [GOC:mlg]
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0043336
name: site-specific telomere resolvase activity
namespace: molecular_function
def: "Catalysis of a site-specific breakage and reunion reaction that generates two hairpin telomeres from a replicated telomere substrate. Occurs via a two-step transesterification with a protein-DNA intermediate similar to that used by topoisomerases and site-specific recombinases." [GOC:jl, PMID:11804598]
comment: Note that while this enzyme uses a similar reaction chemistry to topoisomerases and site-specific recombinases, it performs a unique reaction. Topoisomerases promote breakage and reunion of either one or two DNA strands to alter the topological state of a DNA molecule. Site-specific recombinases perform a more complex reaction in which four strands are broken and subsequently joined to a different DNA duplex, resulting in the production of a recombinant product. The telomere resolvases on the other hand, must break two phosphodiester bonds in a single DNA duplex (one on each strand) and join each end with the opposite DNA strand to form covalently closed hairpin telomeres.
synonym: "ResT" NARROW []
synonym: "TelN" NARROW []
is_a: GO:0003824 ! catalytic activity
relationship: part_of GO:0000723 ! telomere maintenance

[Term]
id: GO:0043337
name: CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CDP-diacylglycerol + phosphatidylglycerol = CMP + diphosphatidylglycerol." [GOC:jl]
synonym: "cardiolipin synthase" BROAD []
synonym: "cardiolipin synthetase" BROAD []
xref: MetaCyc:RXN-8141
is_a: GO:0030572 ! phosphatidyltransferase activity

[Term]
id: GO:0043338
name: CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CTP + 2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate = CDP-2,3-di-O-geranylgeranyl-sn-glycerol." [GOC:jl, PMID:10960477]
synonym: "CDP-2,3-di-O-geranylgeranyl-sn-glycerol synthase" BROAD []
xref: EC:2.7.7.-
is_a: GO:0070567 ! cytidylyltransferase activity

[Term]
id: GO:0043353
name: enucleate erythrocyte differentiation
namespace: biological_process
def: "The process in which a myeloid precursor cell acquires specialized features of an erythrocyte without a nucleus. An example of this process is found in Mus musculus." [GOC:go_curators]
synonym: "enucleate RBC differentiation" EXACT [CL:0000232]
synonym: "enucleate red blood cell differentiation" EXACT [CL:0000232]
is_a: GO:0030218 ! erythrocyte differentiation

[Term]
id: GO:0043354
name: enucleate erythrocyte maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for an enucleate erythrocyte to attain its fully functional state. An enucleate erythrocyte is an erythrocyte without a nucleus." [GOC:go_curators]
synonym: "enucleate RBC maturation" EXACT [CL:0000232]
synonym: "enucleate red blood cell maturation" EXACT [CL:0000232]
is_a: GO:0043249 ! erythrocyte maturation
relationship: part_of GO:0048822 ! enucleate erythrocyte development

[Term]
id: GO:0043362
name: nucleate erythrocyte maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a nucleate erythrocyte to attain its fully functional state. A nucleate erythrocyte is an erythrocyte with a nucleus." [GOC:devbiol, GOC:jl]
synonym: "nucleate RBC maturation" EXACT [CL:0000232]
synonym: "nucleate red blood cell maturation" EXACT [CL:0000232]
is_a: GO:0043249 ! erythrocyte maturation
relationship: part_of GO:0048823 ! nucleate erythrocyte development

[Term]
id: GO:0043363
name: nucleate erythrocyte differentiation
namespace: biological_process
def: "The process in which a myeloid precursor cell acquires specializes features of an erythrocyte with a nucleus, as found in non-mammalian vertebrates such as birds." [GOC:jl]
synonym: "nucleate RBC differentiation" EXACT [CL:0000232]
synonym: "nucleate red blood cell differentiation" EXACT [CL:0000232]
is_a: GO:0030218 ! erythrocyte differentiation

[Term]
id: GO:0043364
name: catalysis of free radical formation
namespace: molecular_function
def: "Catalysis of a reaction that generates a free radical, a highly reactive molecule with an unsatisfied electron valence pair." [GOC:jl]
subset: goslim_pir
synonym: "catalysis of free radical generation" EXACT []
synonym: "catalysis of free-radical biosynthesis" EXACT []
synonym: "catalysis of free-radical formation" EXACT []
synonym: "catalysis of free-radical generation" EXACT []
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0043365
name: [formate-C-acetyltransferase]-activating enzyme activity
namespace: molecular_function
alt_id: GO:0008862
def: "Catalysis of the reaction: S-adenosyl-L-methionine + dihydroflavodoxin + [formate C-acetyltransferase]-glycine = 5'-deoxyadenosine + L-methionine + flavodoxin semiquinone + [formate C-acetyltransferase]-glycin-2-yl radical." [EC:1.97.1.4, GOC:jl, PMID:18307109]
synonym: "[pyruvate formate-lyase]-activating enzyme activity" EXACT [EC:1.97.1.4]
synonym: "formate acetyltransferase activating enzyme activity" EXACT [EC:1.97.1.4]
synonym: "formate acetyltransferase-glycine dihydroflavodoxin:S-adenosyl-L-methionine oxidoreductase (S-adenosyl-L-methionine cleaving) activity" EXACT [EC:1.97.1.4]
synonym: "formate C-acetyltransferase-glycine dihydroflavodoxin:S-adenosyl-L-methionine oxidoreductase (S-adenosyl-L-methionine cleaving)" EXACT [EC:1.97.1.4]
synonym: "formate-C-acetyltransferase-activating enzyme" RELATED [EC:1.97.1.4]
synonym: "PFL activase activity" EXACT [EC:1.97.1.4]
synonym: "PFL-glycine:S-adenosyl-L-methionine H transferase (flavodoxin-oxidizing, S-adenosyl-L-methionine-cleaving) activity" EXACT [EC:1.97.1.4]
synonym: "pyruvate formate-lyase-activating enzyme" RELATED [EC:1.97.1.4]
xref: EC:1.97.1.4
xref: MetaCyc:TDCEACT-RXN
is_a: GO:0016491 ! oxidoreductase activity
is_a: GO:0043364 ! catalysis of free radical formation
is_a: GO:0070283 ! radical SAM enzyme activity

[Term]
id: GO:0043366
name: beta selection
namespace: biological_process
def: "The process in which successful recombination of a T cell receptor beta chain into a translatable protein coding sequence leads to rescue from apoptosis and subsequent proliferation of an immature T cell." [ISBN:0781735149, PMID:12220932]
is_a: GO:0045058 ! T cell selection
relationship: part_of GO:0046632 ! alpha-beta T cell differentiation

[Term]
id: GO:0043367
name: CD4-positive, alpha-beta T cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized T cell acquires specialized features of a mature CD4-positive, alpha-beta T cell." [CL:0000624, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "CD4-positive, alpha beta T cell development" RELATED [GOC:add]
synonym: "CD4-positive, alpha beta T cell differentiation" EXACT [GOC:bf]
synonym: "CD4-positive, alpha-beta T lymphocyte differentiation" EXACT []
synonym: "CD4-positive, alpha-beta T-cell differentiation" EXACT []
synonym: "CD4-positive, alpha-beta T-lymphocyte differentiation" EXACT []
is_a: GO:0035710 ! CD4-positive, alpha-beta T cell activation
is_a: GO:0046632 ! alpha-beta T cell differentiation

[Term]
id: GO:0043368
name: positive T cell selection
namespace: biological_process
def: "The process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death." [ISBN:0781735149, PMID:12414722]
synonym: "positive T lymphocyte selection" EXACT []
synonym: "positive T-cell selection" EXACT []
synonym: "positive T-lymphocyte selection" EXACT []
is_a: GO:0045058 ! T cell selection

[Term]
id: GO:0043369
name: CD4-positive or CD8-positive, alpha-beta T cell lineage commitment
namespace: biological_process
def: "The process in which an immature T cell commits to CD4-positive T cell lineage or the CD8-positive lineage of alpha-beta T cells." [ISBN:0781735149]
synonym: "CD4-positive or CD8-positive, alpha-beta T lymphocyte lineage commitment" EXACT []
synonym: "CD4-positive or CD8-positive, alpha-beta T-cell lineage commitment" EXACT []
synonym: "CD4-positive or CD8-positive, alpha-beta T-lymphocyte lineage commitment" EXACT []
synonym: "CD4-positive/CD8-positive, alpha-beta T cell lineage commitment" EXACT []
is_a: GO:0002360 ! T cell lineage commitment
relationship: part_of GO:0043368 ! positive T cell selection

[Term]
id: GO:0043370
name: regulation of CD4-positive, alpha-beta T cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of CD4-positive, alpha-beta T cell differentiation." [GOC:add, GOC:pr, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "regulation of CD4-positive T lymphocyte differentiation" EXACT []
synonym: "regulation of CD4-positive T-cell differentiation" EXACT []
synonym: "regulation of CD4-positive T-lymphocyte differentiation" EXACT []
synonym: "regulation of CD4-positive, alpha beta T cell development" RELATED [GOC:add]
synonym: "regulation of CD4-positive, alpha beta T cell differentiation" EXACT [GOC:bf]
synonym: "regulation of CD4-positive, alpha beta T lymphocyte differentiation" EXACT []
synonym: "regulation of CD4-positive, alpha beta T-cell differentiation" EXACT []
synonym: "regulation of CD4-positive, alpha beta T-lymphocyte differentiation" EXACT []
is_a: GO:0046637 ! regulation of alpha-beta T cell differentiation
is_a: GO:2000514 ! regulation of CD4-positive, alpha-beta T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043367 ! CD4-positive, alpha-beta T cell differentiation
relationship: regulates GO:0043367 ! CD4-positive, alpha-beta T cell differentiation

[Term]
id: GO:0043371
name: negative regulation of CD4-positive, alpha-beta T cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of CD4-positive, alpha-beta T cell differentiation." [GOC:add, GOC:pr, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "down regulation of CD4-positive, alpha beta T cell differentiation" EXACT []
synonym: "down-regulation of CD4-positive, alpha beta T cell differentiation" EXACT []
synonym: "downregulation of CD4-positive, alpha beta T cell differentiation" EXACT []
synonym: "inhibition of CD4-positive, alpha beta T cell differentiation" NARROW []
synonym: "negative regulation of CD4-positive T-cell differentiation" EXACT []
synonym: "negative regulation of CD4-positive T-lymphocyte differentiation" EXACT []
synonym: "negative regulation of CD4-positive, alpha beta T cell development" RELATED [GOC:add]
synonym: "negative regulation of CD4-positive, alpha beta T lymphocyte differentiation" EXACT []
synonym: "negative regulation of CD4-positive, alpha beta T-cell differentiation" EXACT []
synonym: "negative regulation of CD4-positive, alpha beta T-lymphocyte differentiation" EXACT []
is_a: GO:0043370 ! regulation of CD4-positive, alpha-beta T cell differentiation
is_a: GO:0046639 ! negative regulation of alpha-beta T cell differentiation
is_a: GO:2000515 ! negative regulation of CD4-positive, alpha-beta T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043367 ! CD4-positive, alpha-beta T cell differentiation
relationship: negatively_regulates GO:0043367 ! CD4-positive, alpha-beta T cell differentiation

[Term]
id: GO:0043372
name: positive regulation of CD4-positive, alpha-beta T cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell differentiation." [GOC:add, GOC:pr, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "activation of CD4-positive, alpha beta T cell differentiation" NARROW []
synonym: "positive regulation of CD4-positive T lymphocyte differentiation" EXACT []
synonym: "positive regulation of CD4-positive T-cell differentiation" EXACT []
synonym: "positive regulation of CD4-positive T-lymphocyte differentiation" EXACT []
synonym: "positive regulation of CD4-positive, alpha beta T cell development" RELATED [GOC:add]
synonym: "positive regulation of CD4-positive, alpha beta T cell differentiation" EXACT [GOC:bf]
synonym: "positive regulation of CD4-positive, alpha beta T lymphocyte differentiation" EXACT []
synonym: "positive regulation of CD4-positive, alpha beta T-cell differentiation" EXACT []
synonym: "positive regulation of CD4-positive, alpha beta T-lymphocyte differentiation" EXACT []
synonym: "stimulation of CD4-positive, alpha beta T cell differentiation" NARROW []
synonym: "up regulation of CD4-positive, alpha beta T cell differentiation" EXACT []
synonym: "up-regulation of CD4-positive, alpha beta T cell differentiation" EXACT []
synonym: "upregulation of CD4-positive, alpha beta T cell differentiation" EXACT []
is_a: GO:0043370 ! regulation of CD4-positive, alpha-beta T cell differentiation
is_a: GO:0046638 ! positive regulation of alpha-beta T cell differentiation
is_a: GO:2000516 ! positive regulation of CD4-positive, alpha-beta T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043367 ! CD4-positive, alpha-beta T cell differentiation
relationship: positively_regulates GO:0043367 ! CD4-positive, alpha-beta T cell differentiation

[Term]
id: GO:0043373
name: CD4-positive, alpha-beta T cell lineage commitment
namespace: biological_process
def: "The process in which an immature T cell becomes committed to becoming a CD4-positive, alpha-beta T cell." [ISBN:0781735149]
synonym: "CD4-positive, alpha-beta T lymphocyte lineage commitment" EXACT []
synonym: "CD4-positive, alpha-beta T-cell lineage commitment" EXACT []
synonym: "CD4-positive, alpha-beta T-lymphocyte lineage commitment" EXACT []
is_a: GO:0002363 ! alpha-beta T cell lineage commitment
is_a: GO:0043369 ! CD4-positive or CD8-positive, alpha-beta T cell lineage commitment
relationship: part_of GO:0043367 ! CD4-positive, alpha-beta T cell differentiation

[Term]
id: GO:0043374
name: CD8-positive, alpha-beta T cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized T cell acquires specialized features of a mature CD8-positive, alpha-beta T cell." [ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "CD8-positive, alpha-beta T cell development" RELATED [GOC:add]
synonym: "CD8-positive, alpha-beta T lymphocyte differentiation" EXACT []
synonym: "CD8-positive, alpha-beta T-cell differentiation" EXACT []
synonym: "CD8-positive, alpha-beta T-lymphocyte differentiation" EXACT []
is_a: GO:0036037 ! CD8-positive, alpha-beta T cell activation
is_a: GO:0046632 ! alpha-beta T cell differentiation

[Term]
id: GO:0043375
name: CD8-positive, alpha-beta T cell lineage commitment
namespace: biological_process
def: "The process in which an immature T cell becomes committed to becoming a CD8-positive, alpha-beta T cell." [ISBN:0781735149]
synonym: "CD8-positive, alpha-beta T cell fate commitment" EXACT []
synonym: "CD8-positive, alpha-beta T lymphocyte lineage commitment" EXACT []
synonym: "CD8-positive, alpha-beta T-cell lineage commitment" EXACT []
synonym: "CD8-positive, alpha-beta T-lymphocyte lineage commitment" EXACT []
is_a: GO:0002363 ! alpha-beta T cell lineage commitment
is_a: GO:0043369 ! CD4-positive or CD8-positive, alpha-beta T cell lineage commitment
relationship: part_of GO:0043374 ! CD8-positive, alpha-beta T cell differentiation

[Term]
id: GO:0043376
name: regulation of CD8-positive, alpha-beta T cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of CD8-positive, alpha-beta T cell differentiation." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "regulation of CD8-positive T lymphocyte differentiation" EXACT []
synonym: "regulation of CD8-positive T-cell differentiation" EXACT []
synonym: "regulation of CD8-positive T-lymphocyte differentiation" EXACT []
synonym: "regulation of CD8-positive, alpha beta T lymphocyte differentiation" EXACT []
synonym: "regulation of CD8-positive, alpha beta T-cell differentiation" EXACT []
synonym: "regulation of CD8-positive, alpha beta T-lymphocyte differentiation" EXACT []
synonym: "regulation of CD8-positive, alpha-beta T cell development" RELATED [GOC:add]
is_a: GO:0046637 ! regulation of alpha-beta T cell differentiation
is_a: GO:2001185 ! regulation of CD8-positive, alpha-beta T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043374 ! CD8-positive, alpha-beta T cell differentiation
relationship: regulates GO:0043374 ! CD8-positive, alpha-beta T cell differentiation

[Term]
id: GO:0043377
name: negative regulation of CD8-positive, alpha-beta T cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of CD8-positive, alpha-beta T cell differentiation." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "down regulation of CD8-positive, alpha-beta T cell differentiation" EXACT []
synonym: "down-regulation of CD8-positive, alpha-beta T cell differentiation" EXACT []
synonym: "downregulation of CD8-positive, alpha-beta T cell differentiation" EXACT []
synonym: "inhibition of CD8-positive, alpha-beta T cell differentiation" NARROW []
synonym: "negative regulation of CD8-positive T lymphocyte differentiation" EXACT []
synonym: "negative regulation of CD8-positive T-cell differentiation" EXACT []
synonym: "negative regulation of CD8-positive T-lymphocyte differentiation" EXACT []
synonym: "negative regulation of CD8-positive, alpha beta T lymphocyte differentiation" EXACT []
synonym: "negative regulation of CD8-positive, alpha beta T-cell differentiation" EXACT []
synonym: "negative regulation of CD8-positive, alpha beta T-lymphocyte differentiation" EXACT []
synonym: "negative regulation of CD8-positive, alpha-beta T cell development" RELATED [GOC:add]
is_a: GO:0043376 ! regulation of CD8-positive, alpha-beta T cell differentiation
is_a: GO:0046639 ! negative regulation of alpha-beta T cell differentiation
is_a: GO:2001186 ! negative regulation of CD8-positive, alpha-beta T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043374 ! CD8-positive, alpha-beta T cell differentiation
relationship: negatively_regulates GO:0043374 ! CD8-positive, alpha-beta T cell differentiation

[Term]
id: GO:0043378
name: positive regulation of CD8-positive, alpha-beta T cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell differentiation." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "activation of CD8-positive, alpha-beta T cell differentiation" NARROW []
synonym: "positive regulation of CD8-positive T lymphocyte differentiation" EXACT []
synonym: "positive regulation of CD8-positive T-cell differentiation" EXACT []
synonym: "positive regulation of CD8-positive T-lymphocyte differentiation" EXACT []
synonym: "positive regulation of CD8-positive, alpha beta T lymphocyte differentiation" EXACT []
synonym: "positive regulation of CD8-positive, alpha beta T-cell differentiation" EXACT []
synonym: "positive regulation of CD8-positive, alpha beta T-lymphocyte differentiation" EXACT []
synonym: "positive regulation of CD8-positive, alpha-beta T cell development" RELATED [GOC:add]
synonym: "stimulation of CD8-positive, alpha-beta T cell differentiation" NARROW []
synonym: "up regulation of CD8-positive, alpha-beta T cell differentiation" EXACT []
synonym: "up-regulation of CD8-positive, alpha-beta T cell differentiation" EXACT []
synonym: "upregulation of CD8-positive, alpha-beta T cell differentiation" EXACT []
is_a: GO:0043376 ! regulation of CD8-positive, alpha-beta T cell differentiation
is_a: GO:0046638 ! positive regulation of alpha-beta T cell differentiation
is_a: GO:2001187 ! positive regulation of CD8-positive, alpha-beta T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043374 ! CD8-positive, alpha-beta T cell differentiation
relationship: positively_regulates GO:0043374 ! CD8-positive, alpha-beta T cell differentiation

[Term]
id: GO:0043379
name: memory T cell differentiation
namespace: biological_process
def: "The process in which a newly activated T cell acquires specialized features of a memory T cell." [ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "memory T cell development" RELATED [GOC:add]
synonym: "memory T lymphocyte differentiation" EXACT []
synonym: "memory T-cell differentiation" EXACT []
synonym: "memory T-lymphocyte differentiation" EXACT []
is_a: GO:0002292 ! T cell differentiation involved in immune response

[Term]
id: GO:0043380
name: regulation of memory T cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of memory T cell differentiation." [ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "regulation of memory T cell development" RELATED [GOC:add]
synonym: "regulation of memory T lymphocyte differentiation" EXACT []
synonym: "regulation of memory T-cell differentiation" EXACT []
synonym: "regulation of memory T-lymphocyte differentiation" EXACT []
is_a: GO:0002697 ! regulation of immune effector process
is_a: GO:0045580 ! regulation of T cell differentiation
is_a: GO:0050776 ! regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043379 ! memory T cell differentiation
relationship: regulates GO:0043379 ! memory T cell differentiation

[Term]
id: GO:0043381
name: negative regulation of memory T cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of memory T cell differentiation." [ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "down regulation of memory T cell differentiation" EXACT []
synonym: "down-regulation of memory T cell differentiation" EXACT []
synonym: "downregulation of memory T cell differentiation" EXACT []
synonym: "inhibition of memory T cell differentiation" NARROW []
synonym: "negative regulation of memory T cell development" RELATED [GOC:add]
synonym: "negative regulation of memory T lymphocyte differentiation" EXACT []
synonym: "negative regulation of memory T-cell differentiation" EXACT []
synonym: "negative regulation of memory T-lymphocyte differentiation" EXACT []
is_a: GO:0002698 ! negative regulation of immune effector process
is_a: GO:0043380 ! regulation of memory T cell differentiation
is_a: GO:0045581 ! negative regulation of T cell differentiation
is_a: GO:0050777 ! negative regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043379 ! memory T cell differentiation
relationship: negatively_regulates GO:0043379 ! memory T cell differentiation

[Term]
id: GO:0043382
name: positive regulation of memory T cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of memory T cell differentiation." [ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "activation of memory T cell differentiation" NARROW []
synonym: "positive regulation of memory T cell development" RELATED [GOC:add]
synonym: "positive regulation of memory T lymphocyte differentiation" EXACT []
synonym: "positive regulation of memory T-cell differentiation" EXACT []
synonym: "positive regulation of memory T-lymphocyte differentiation" EXACT []
synonym: "stimulation of memory T cell differentiation" NARROW []
synonym: "up regulation of memory T cell differentiation" EXACT []
synonym: "up-regulation of memory T cell differentiation" EXACT []
synonym: "upregulation of memory T cell differentiation" EXACT []
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0043380 ! regulation of memory T cell differentiation
is_a: GO:0045582 ! positive regulation of T cell differentiation
is_a: GO:0050778 ! positive regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043379 ! memory T cell differentiation
relationship: positively_regulates GO:0043379 ! memory T cell differentiation

[Term]
id: GO:0043383
name: negative T cell selection
namespace: biological_process
def: "The process of elimination of immature T cells which react strongly with self-antigens." [ISBN:0781735149, PMID:12414722]
synonym: "negative T lymphocyte selection" EXACT []
synonym: "negative T-cell selection" EXACT []
synonym: "negative T-lymphocyte selection" EXACT []
is_a: GO:0045058 ! T cell selection

[Term]
id: GO:0043384
name: pre-T cell receptor complex
namespace: cellular_component
def: "A receptor complex found on immature T cells consisting of a T cell receptor beta chain and the pre-TCR-alpha chain, along with additional signaling components including CD3 family members and additional signaling proteins." [ISBN:0781735149, PMID:12220932]
synonym: "pre-T lymphocyte receptor complex" EXACT []
synonym: "pre-T-cell receptor complex" EXACT []
synonym: "pre-T-lymphocyte receptor complex" EXACT []
synonym: "pre-TCR complex" EXACT []
is_a: GO:0098802 ! plasma membrane receptor complex
relationship: part_of GO:0005887 ! integral component of plasma membrane

[Term]
id: GO:0043385
name: mycotoxin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a mycotoxin, any poisonous substance produced by a fungus." [CHEBI:25442, GOC:jl]
subset: gosubset_prok
synonym: "mycotoxin metabolism" EXACT []
is_a: GO:0009404 ! toxin metabolic process

[Term]
id: GO:0043386
name: mycotoxin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a mycotoxin, any poisonous substance produced by a fungus." [CHEBI:25442, GOC:jl]
subset: gosubset_prok
synonym: "mycotoxin anabolism" EXACT []
synonym: "mycotoxin biosynthesis" EXACT []
synonym: "mycotoxin formation" EXACT []
synonym: "mycotoxin synthesis" EXACT []
is_a: GO:0009403 ! toxin biosynthetic process
is_a: GO:0043385 ! mycotoxin metabolic process

[Term]
id: GO:0043387
name: mycotoxin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a mycotoxin, any poisonous substance produced by a fungus." [CHEBI:25442, GOC:jl]
subset: gosubset_prok
synonym: "mycotoxin breakdown" EXACT []
synonym: "mycotoxin catabolism" EXACT []
synonym: "mycotoxin degradation" EXACT []
is_a: GO:0009407 ! toxin catabolic process
is_a: GO:0043385 ! mycotoxin metabolic process

[Term]
id: GO:0043388
name: positive regulation of DNA binding
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]
subset: gosubset_prok
synonym: "activation of DNA binding" NARROW []
synonym: "stimulation of DNA binding" NARROW []
synonym: "up regulation of DNA binding" EXACT []
synonym: "up-regulation of DNA binding" EXACT []
synonym: "upregulation of DNA binding" EXACT []
is_a: GO:0051099 ! positive regulation of binding
is_a: GO:0051101 ! regulation of DNA binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003677 ! DNA binding
relationship: positively_regulates GO:0003677 ! DNA binding

[Term]
id: GO:0043390
name: aflatoxin B1 metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aflatoxin B1, a potent hepatotoxic and hepatocarcinogenic mycotoxin produced by various species from the Aspergillus group of fungi." [CHEBI:2504, GOC:jl]
synonym: "aflatoxin B1 metabolism" EXACT []
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0018904 ! ether metabolic process
is_a: GO:0042180 ! cellular ketone metabolic process
is_a: GO:0046222 ! aflatoxin metabolic process

[Term]
id: GO:0043391
name: aflatoxin B2 metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aflatoxin B2, a mycotoxin produced by the fungal species Aspergillus flavus, Aspergillus parasiticus and Aspergillus nomius." [GOC:jl, http://www.aspergillus.man.ac.uk/]
synonym: "aflatoxin B2 metabolism" EXACT []
is_a: GO:0046222 ! aflatoxin metabolic process

[Term]
id: GO:0043392
name: negative regulation of DNA binding
namespace: biological_process
def: "Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]
subset: gosubset_prok
synonym: "down regulation of DNA binding" EXACT []
synonym: "down-regulation of DNA binding" EXACT []
synonym: "downregulation of DNA binding" EXACT []
synonym: "inhibition of DNA binding" NARROW []
is_a: GO:0051100 ! negative regulation of binding
is_a: GO:0051101 ! regulation of DNA binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003677 ! DNA binding
relationship: negatively_regulates GO:0003677 ! DNA binding

[Term]
id: GO:0043393
name: regulation of protein binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein binding." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0051098 ! regulation of binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0005515 ! protein binding
relationship: regulates GO:0005515 ! protein binding

[Term]
id: GO:0043394
name: proteoglycan binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a proteoglycan, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [ISBN:0198506732]
is_a: GO:0001948 ! glycoprotein binding

[Term]
id: GO:0043395
name: heparan sulfate proteoglycan binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit." [ISBN:0198506732]
synonym: "heparin proteoglycan binding" RELATED []
is_a: GO:0043168 ! anion binding
is_a: GO:0043394 ! proteoglycan binding
is_a: GO:1901681 ! sulfur compound binding

[Term]
id: GO:0043396
name: corticotropin-releasing hormone secretion
namespace: biological_process
def: "The regulated release of corticotropin-releasing hormone (CRH), a polypeptide hormone involved in the stress response. CRH is produced by the hypothalamus and stimulates corticotropic cells of the anterior lobe of the pituitary to produce corticotropic hormone (CTH) and other biologically active substances e.g. 2-endorphin, release of CRH is affected by serum levels of cortisol, by stress and by the sleep/wake cycle." [GOC:go_curators, PMID:11027914]
synonym: "corticotropin-releasing factor secretion" EXACT []
synonym: "CRF secretion" EXACT []
synonym: "CRH secretion" EXACT []
is_a: GO:0030072 ! peptide hormone secretion

[Term]
id: GO:0043397
name: regulation of corticotropin-releasing hormone secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of corticotropin-releasing hormone secretion." [GOC:go_curators, PMID:11027914]
synonym: "regulation of corticotropin-releasing factor secretion" EXACT []
synonym: "regulation of CRF secretion" EXACT []
synonym: "regulation of CRH secretion" EXACT []
is_a: GO:0090276 ! regulation of peptide hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043396 ! corticotropin-releasing hormone secretion
relationship: regulates GO:0043396 ! corticotropin-releasing hormone secretion

[Term]
id: GO:0043398
name: HLH domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with Helix Loop Helix, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization." [GOC:go_curators, Prosite:PDOC0038]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0043399
name: tRNA A64-2'-O-ribosylphosphate transferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a phosphoribosyl group from 5'-phosphoribosyl-1'-pyrophosphate to position 64 of initiator tRNA." [GOC:jl, PMID:7954819]
synonym: "initiator tRNA phosphoribosyl-transferase activity" EXACT []
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0043400
name: cortisol secretion
namespace: biological_process
def: "The regulated release of cortisol, a steroid hormone that in humans is the major circulating hormone of the cortex, or outer layer, of the adrenal gland." [CHEBI:17650, PMID:11027914]
synonym: "hydrocortisone secretion" EXACT [CHEBI:17650]
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0035933 ! glucocorticoid secretion

[Term]
id: GO:0043401
name: steroid hormone mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals mediated by a steroid hormone binding to a receptor." [PMID:12606724]
synonym: "steroid hormone mediated signalling" EXACT []
is_a: GO:0009755 ! hormone-mediated signaling pathway
relationship: part_of GO:0071383 ! cellular response to steroid hormone stimulus

[Term]
id: GO:0043402
name: glucocorticoid mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals mediated by the detection of a glucocorticoid hormone." [PMID:15240347]
synonym: "glucocorticoid mediated signalling" EXACT []
is_a: GO:0043401 ! steroid hormone mediated signaling pathway
relationship: part_of GO:0071385 ! cellular response to glucocorticoid stimulus

[Term]
id: GO:0043403
name: skeletal muscle tissue regeneration
namespace: biological_process
def: "The regrowth of skeletal muscle tissue to repair injured or damaged muscle fibers in the postnatal stage." [GOC:ef, GOC:mtg_muscle, PMID:12021255, PMID:16607119]
synonym: "myofiber turnover" RELATED []
is_a: GO:0042246 ! tissue regeneration

[Term]
id: GO:0043404
name: corticotropin-releasing hormone receptor activity
namespace: molecular_function
alt_id: GO:0031636
def: "Combining with corticotropin-releasing hormone and transmitting the signal to initiate a change in cell activity." [GOC:signaling, ISBN:0838577016, PMID:11027914, PMID:15134857]
synonym: "adrenocorticotropin-releasing hormone receptor activity" EXACT []
synonym: "corticotropin-releasing factor receptor activity" EXACT [GOC:bf]
synonym: "CRF receptor activity" EXACT [GOC:bf]
synonym: "CRH receptor activity" EXACT [GOC:bf]
is_a: GO:0001653 ! peptide receptor activity
relationship: has_part GO:0051424 ! corticotropin-releasing hormone binding
relationship: part_of GO:0009755 ! hormone-mediated signaling pathway

[Term]
id: GO:0043405
name: regulation of MAP kinase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of MAP kinase activity." [GOC:dph, GOC:go_curators]
synonym: "Regulation of MAPK activity" EXACT [GOC:dph]
synonym: "regulation of mitogen activated protein kinase activity" EXACT []
synonym: "regulation of mitogen-activated protein kinase activity" EXACT []
is_a: GO:0043408 ! regulation of MAPK cascade
is_a: GO:0071900 ! regulation of protein serine/threonine kinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004707 ! MAP kinase activity
relationship: regulates GO:0004707 ! MAP kinase activity

[Term]
id: GO:0043406
name: positive regulation of MAP kinase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of MAP kinase activity." [GOC:dph, GOC:go_curators]
synonym: "positive regulation of mitogen activated protein kinase activity" EXACT []
synonym: "positive regulation of mitogen-activated protein kinase activity" EXACT []
synonym: "stimulation of MAPK activity" NARROW []
synonym: "up regulation of MAPK activity" EXACT []
synonym: "up-regulation of MAPK activity" EXACT []
synonym: "upregulation of MAPK activity" EXACT []
is_a: GO:0043405 ! regulation of MAP kinase activity
is_a: GO:0043410 ! positive regulation of MAPK cascade
is_a: GO:0071902 ! positive regulation of protein serine/threonine kinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004707 ! MAP kinase activity
relationship: positively_regulates GO:0004707 ! MAP kinase activity

[Term]
id: GO:0043407
name: negative regulation of MAP kinase activity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity." [GOC:dph, GOC:go_curators]
synonym: "down regulation of MAPK activity" EXACT []
synonym: "down-regulation of MAPK activity" EXACT []
synonym: "downregulation of MAPK activity" EXACT []
synonym: "inhibition of MAPK activity" NARROW []
synonym: "negative regulation of mitogen activated protein kinase activity" EXACT []
synonym: "negative regulation of mitogen-activated protein kinase activity" EXACT []
is_a: GO:0043405 ! regulation of MAP kinase activity
is_a: GO:0043409 ! negative regulation of MAPK cascade
is_a: GO:0071901 ! negative regulation of protein serine/threonine kinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004707 ! MAP kinase activity
relationship: negatively_regulates GO:0004707 ! MAP kinase activity

[Term]
id: GO:0043408
name: regulation of MAPK cascade
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade." [GOC:go_curators]
synonym: "regulation of MAP kinase cascade" EXACT [GOC:signaling]
synonym: "regulation of MAP kinase kinase kinase cascade" EXACT []
synonym: "regulation of MAPKKK cascade" EXACT [GOC:signaling]
synonym: "regulation of mitogen activated protein kinase cascade" EXACT [GOC:signaling]
synonym: "regulation of mitogen activated protein kinase kinase kinase cascade" EXACT []
synonym: "regulation of mitogen-activated protein kinase cascade" EXACT [GOC:signaling]
synonym: "regulation of mitogen-activated protein kinase kinase kinase cascade" EXACT []
is_a: GO:0001932 ! regulation of protein phosphorylation
is_a: GO:1902531 ! regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000165 ! MAPK cascade
relationship: regulates GO:0000165 ! MAPK cascade

[Term]
id: GO:0043409
name: negative regulation of MAPK cascade
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade." [GOC:go_curators]
synonym: "down regulation of MAPK cascade" EXACT [GOC:signaling]
synonym: "down regulation of MAPKKK cascade" EXACT []
synonym: "down-regulation of MAPK cascade" EXACT [GOC:signaling]
synonym: "down-regulation of MAPKKK cascade" EXACT []
synonym: "downregulation of MAPK cascade" EXACT [GOC:signaling]
synonym: "downregulation of MAPKKK cascade" EXACT []
synonym: "inhibition of MAPK cascade" NARROW [GOC:signaling]
synonym: "inhibition of MAPKKK cascade" NARROW []
synonym: "negative regulation of MAP kinase cascade" EXACT [GOC:signaling]
synonym: "negative regulation of MAP kinase kinase kinase cascade" EXACT []
synonym: "negative regulation of MAPKKK cascade" EXACT [GOC:signaling]
synonym: "negative regulation of mitogen activated protein kinase cascade" EXACT [GOC:signaling]
synonym: "negative regulation of mitogen activated protein kinase kinase kinase cascade" EXACT []
synonym: "negative regulation of mitogen-activated protein kinase cascade" EXACT [GOC:signaling]
synonym: "negative regulation of mitogen-activated protein kinase kinase kinase cascade" EXACT []
is_a: GO:0001933 ! negative regulation of protein phosphorylation
is_a: GO:0043408 ! regulation of MAPK cascade
is_a: GO:1902532 ! negative regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000165 ! MAPK cascade
relationship: negatively_regulates GO:0000165 ! MAPK cascade

[Term]
id: GO:0043410
name: positive regulation of MAPK cascade
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade." [GOC:go_curators]
synonym: "activation of MAPK cascade" NARROW [GOC:signaling]
synonym: "activation of MAPKKK cascade" NARROW []
synonym: "positive regulation of MAP kinase cascade" EXACT [GOC:signaling]
synonym: "positive regulation of MAP kinase kinase kinase cascade" EXACT []
synonym: "positive regulation of MAPKKK cascade" EXACT [GOC:signaling]
synonym: "positive regulation of mitogen activated protein kinase kinase kinase cascade" EXACT []
synonym: "positive regulation of mitogen-activated protein kinase cascade" EXACT [GOC:signaling]
synonym: "positive regulation of mitogen-activated protein kinase kinase kinase cascade" EXACT []
synonym: "stimulation of MAPK cascade" EXACT [GOC:signaling]
synonym: "stimulation of MAPKKK cascade" NARROW []
synonym: "up regulation of MAPKKK cascade" EXACT []
synonym: "up-regulation of MAPK cascade" EXACT [GOC:signaling]
synonym: "up-regulation of MAPKKK cascade" EXACT []
synonym: "upregulation of MAPK cascade" EXACT [GOC:signaling]
synonym: "upregulation of MAPKKK cascade" EXACT []
is_a: GO:0001934 ! positive regulation of protein phosphorylation
is_a: GO:0043408 ! regulation of MAPK cascade
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000165 ! MAPK cascade
relationship: positively_regulates GO:0000165 ! MAPK cascade

[Term]
id: GO:0043411
name: obsolete myopalladin binding
namespace: molecular_function
def: "OBSOLETE. Interacting selectively and non-covalently with myopalladin, a myofibrillar protein with titin-like Ig domains." [GOC:go_curators]
comment: This term was made obsolete because it represents binding to an individual protein.
synonym: "myopalladin binding" EXACT []
is_obsolete: true
replaced_by: GO:0008092

[Term]
id: GO:0043412
name: macromolecule modification
namespace: biological_process
def: "The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties." [GOC:go_curators]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0043170 ! macromolecule metabolic process

[Term]
id: GO:0043413
name: macromolecule glycosylation
namespace: biological_process
def: "The covalent attachment of a glycosyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule." [GOC:jl]
subset: gosubset_prok
is_a: GO:0043412 ! macromolecule modification
is_a: GO:0070085 ! glycosylation

[Term]
id: GO:0043414
name: macromolecule methylation
namespace: biological_process
def: "The covalent attachment of a methyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0032259 ! methylation
is_a: GO:0043412 ! macromolecule modification
is_a: GO:0044260 ! cellular macromolecule metabolic process

[Term]
id: GO:0043415
name: positive regulation of skeletal muscle tissue regeneration
namespace: biological_process
def: "Any process that activates or increase the rate of skeletal muscle regeneration." [GOC:jl]
synonym: "activation of skeletal muscle regeneration" NARROW []
synonym: "stimulation of skeletal muscle regeneration" NARROW []
synonym: "up regulation of skeletal muscle regeneration" EXACT []
synonym: "up-regulation of skeletal muscle regeneration" EXACT []
synonym: "upregulation of skeletal muscle regeneration" EXACT []
is_a: GO:0043416 ! regulation of skeletal muscle tissue regeneration
is_a: GO:0048639 ! positive regulation of developmental growth
is_a: GO:0090303 ! positive regulation of wound healing
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043403 ! skeletal muscle tissue regeneration
relationship: positively_regulates GO:0043403 ! skeletal muscle tissue regeneration

[Term]
id: GO:0043416
name: regulation of skeletal muscle tissue regeneration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle." [GOC:jl]
is_a: GO:0032101 ! regulation of response to external stimulus
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:0061041 ! regulation of wound healing
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043403 ! skeletal muscle tissue regeneration
relationship: regulates GO:0043403 ! skeletal muscle tissue regeneration

[Term]
id: GO:0043417
name: negative regulation of skeletal muscle tissue regeneration
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle regeneration." [GOC:jl]
synonym: "down regulation of skeletal muscle regeneration" EXACT []
synonym: "down-regulation of skeletal muscle regeneration" EXACT []
synonym: "downregulation of skeletal muscle regeneration" EXACT []
synonym: "inhibition of skeletal muscle regeneration" NARROW []
is_a: GO:0043416 ! regulation of skeletal muscle tissue regeneration
is_a: GO:0048640 ! negative regulation of developmental growth
is_a: GO:0061045 ! negative regulation of wound healing
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043403 ! skeletal muscle tissue regeneration
relationship: negatively_regulates GO:0043403 ! skeletal muscle tissue regeneration

[Term]
id: GO:0043418
name: homocysteine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid." [GOC:jl]
synonym: "homocysteine breakdown" EXACT []
synonym: "homocysteine catabolism" EXACT []
synonym: "homocysteine degradation" EXACT []
is_a: GO:0000098 ! sulfur amino acid catabolic process
is_a: GO:0042219 ! cellular modified amino acid catabolic process
is_a: GO:0050667 ! homocysteine metabolic process
is_a: GO:1901606 ! alpha-amino acid catabolic process

[Term]
id: GO:0043419
name: urea catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of urea, the water soluble compound O=C-(NH2)2." [GOC:jl]
synonym: "urea breakdown" EXACT []
synonym: "urea catabolism" EXACT []
synonym: "urea decomposition" EXACT []
synonym: "urea degradation" EXACT []
is_a: GO:0019627 ! urea metabolic process
is_a: GO:0043605 ! cellular amide catabolic process
is_a: GO:0044282 ! small molecule catabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process

[Term]
id: GO:0043420
name: anthranilate metabolic process
namespace: biological_process
alt_id: GO:0018869
def: "The chemical reactions and pathways involving anthranilate (2-aminobenzoate)." [CHEBI:16567, GOC:jl]
synonym: "2-aminobenzoate metabolic process" EXACT []
synonym: "2-aminobenzoate metabolism" EXACT []
synonym: "anthranilate metabolism" EXACT []
synonym: "anthranilic acid metabolic process" NARROW []
synonym: "anthranilic acid metabolism" NARROW []
synonym: "ortho-aminobenzoic acid metabolic process" NARROW []
synonym: "ortho-aminobenzoic acid metabolism" NARROW []
xref: UM-BBD_pathwayID:abz2
is_a: GO:0009072 ! aromatic amino acid family metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:0043421
name: anthranilate catabolic process
namespace: biological_process
alt_id: GO:0019259
def: "The chemical reactions and pathways resulting in the breakdown of anthranilate (2-aminobenzoate)." [CHEBI:16567, GOC:jl]
synonym: "2-aminobenzoate breakdown" EXACT []
synonym: "2-aminobenzoate catabolic process" EXACT []
synonym: "2-aminobenzoate catabolism" NARROW []
synonym: "2-aminobenzoate degradation" EXACT []
synonym: "anthranilate breakdown" EXACT []
synonym: "anthranilate catabolism" EXACT []
synonym: "anthranilate degradation" EXACT []
synonym: "anthranilic acid catabolic process" NARROW []
synonym: "anthranilic acid catabolism" NARROW []
synonym: "ortho-aminobenzoic acid catabolic process" NARROW []
synonym: "ortho-aminobenzoic acid catabolism" NARROW []
xref: MetaCyc:2AMINOBENZDEG-PWY
is_a: GO:0009074 ! aromatic amino acid family catabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0043420 ! anthranilate metabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0043422
name: protein kinase B binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with protein kinase B, an intracellular kinase that is important in regulating glucose metabolism." [GOC:jl, http://www.heartandmetabolism.org/]
synonym: "Akt binding" EXACT []
synonym: "PKB binding" EXACT []
is_a: GO:0019901 ! protein kinase binding

[Term]
id: GO:0043423
name: 3-phosphoinositide-dependent protein kinase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a 3-phosphoinositide-dependent protein kinase." [GOC:jl]
synonym: "phosphatidylinositol-3-phosphate-dependent protein kinase binding" EXACT [GOC:curators]
is_a: GO:0019901 ! protein kinase binding

[Term]
id: GO:0043424
name: protein histidine kinase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with protein histidine kinase." [GOC:jl]
synonym: "histidine kinase binding" EXACT []
synonym: "histidine-protein kinase binding" EXACT []
synonym: "protein-histidine kinase binding" EXACT []
is_a: GO:0019901 ! protein kinase binding

[Term]
id: GO:0043425
name: bHLH transcription factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways." [PMID:9144210]
is_a: GO:0008134 ! transcription factor binding

[Term]
id: GO:0043426
name: MRF binding
namespace: molecular_function
alt_id: GO:0051576
alt_id: GO:0051577
alt_id: GO:0051578
alt_id: GO:0051579
def: "Interacting selectively and non-covalently with Myogenic Regulatory Factor (MRF), a member of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors." [PMID:10966875]
synonym: "Mrf4 binding" NARROW []
synonym: "Myf5 binding" NARROW []
synonym: "MyoD binding" NARROW []
synonym: "myogenin binding" NARROW []
is_a: GO:0043425 ! bHLH transcription factor binding

[Term]
id: GO:0043427
name: carbon fixation by 3-hydroxypropionate cycle
namespace: biological_process
def: "An autotrophic carbon dioxide fixation pathway by which two molecules of carbon dioxide are fixed to form glyoxylate. Acetyl coenzyme A (acetyl-CoA) is assumed to be converted to malate, and two CO2 molecules are thereby fixed. Malyl-CoA is thought to be cleaved to acetyl-CoA, the starting molecule, and glyoxylate, the carbon fixation product." [GOC:jl, PMID:11418572, PMID:15838028]
synonym: "3-hydroxypropionate cycle" EXACT []
synonym: "3-hydroxypropionate pathway" EXACT []
synonym: "hydroxypropionate cycle" EXACT []
synonym: "hydroxypropionate pathway" EXACT []
is_a: GO:0015977 ! carbon fixation

[Term]
id: GO:0043428
name: 2-heptaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-heptaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-heptaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:jl, PMID:11583838]
comment: Note that the polyprenyl sidechain substrate for these methyltransferases varies in length between species, for example, 6 units in S. cerevisiae, 8 units in E. coli and 10 units in G. suboxidans. Where the length of the substrate polyprenyl chain is unknown, the term '2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity ; GO:0008425' should be used.
synonym: "2-heptaprenyl-6-methoxy-1,4-benzoquinone methylase activity" EXACT []
xref: MetaCyc:RXN-9227
is_a: GO:0008425 ! 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity

[Term]
id: GO:0043429
name: 2-nonaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-nonaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:jl, PMID:11583838]
comment: Note that the polyprenyl sidechain substrate for these methyltransferases varies in length between species, for example, 6 units in S. cerevisiae, 8 units in E. coli and 10 units in G. suboxidans. Where the length of the substrate polyprenyl chain is unknown, the term '2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity ; GO:0008425' should be used.
synonym: "2-nonaprenyl-6-methoxy-1,4-benzoquinone methylase activity" EXACT []
is_a: GO:0008425 ! 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity

[Term]
id: GO:0043430
name: 2-decaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-decaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-decaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:jl, PMID:11583838]
comment: Note that the polyprenyl sidechain substrate for these methyltransferases varies in length between species, for example, 6 units in S. cerevisae, 8 units in E. coli and 10 units in G. suboxidans. Where the length of the substrate polyprenyl chain is unknown, the term '2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity ; GO:0008425' should be used.
synonym: "2-decaprenyl-6-methoxy-1,4-benzoquinone methylase activity" EXACT []
is_a: GO:0008425 ! 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity

[Term]
id: GO:0043431
name: 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol + S-adenosyl-L-methionine = ubiquinol + S-adenosyl-L-homocysteine." [GOC:jl, PMID:11583838, PMID:1479344]
synonym: "2-octaprenyl-6-hydroxy phenol methylase activity" EXACT []
synonym: "3-demethylubiquinone-9 3-methyltransferase activity" EXACT []
xref: MetaCyc:2.1.1.64-RXN
is_a: GO:0008171 ! O-methyltransferase activity

[Term]
id: GO:0043433
name: negative regulation of sequence-specific DNA binding transcription factor activity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:jl]
synonym: "down regulation of transcription factor activity" EXACT []
synonym: "down-regulation of transcription factor activity" EXACT []
synonym: "downregulation of transcription factor activity" EXACT []
synonym: "inhibition of transcription factor activity" NARROW []
synonym: "negative regulation of transcription factor activity" BROAD [GOC:dph, GOC:tb]
is_a: GO:0044092 ! negative regulation of molecular function
is_a: GO:0045892 ! negative regulation of transcription, DNA-templated
is_a: GO:0051090 ! regulation of sequence-specific DNA binding transcription factor activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003700 ! transcription factor activity, sequence-specific DNA binding
relationship: negatively_regulates GO:0003700 ! transcription factor activity, sequence-specific DNA binding

[Term]
id: GO:0043434
name: response to peptide hormone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [PMID:11027914, PMID:15134857, Wikipedia:Peptide_hormone]
synonym: "response to peptide hormone stimulus" EXACT [GOC:dos]
synonym: "response to polypeptide hormone stimulus" EXACT []
is_a: GO:0009725 ! response to hormone
is_a: GO:1901652 ! response to peptide

[Term]
id: GO:0043435
name: response to corticotropin-releasing hormone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticotropin-releasing hormone stimulus. Corticotropin-releasing hormone is a peptide hormone involved in the stress response." [PMID:11027914, PMID:15134857, Wikipedia:Corticotropin-releasing_hormone]
synonym: "response to corticoliberin stimulus" EXACT []
synonym: "response to corticotropin-releasing factor stimulus" EXACT []
synonym: "response to corticotropin-releasing hormone stimulus" EXACT [GOC:dos]
synonym: "response to CRF stimulus" EXACT []
synonym: "response to CRH stimulus" EXACT []
is_a: GO:0043434 ! response to peptide hormone

[Term]
id: GO:0043436
name: oxoacid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons)." [CHEBI:24833]
subset: gosubset_prok
synonym: "keto acid metabolic process" EXACT []
synonym: "keto acid metabolism" EXACT []
synonym: "ketoacid metabolic process" EXACT []
synonym: "ketoacid metabolism" EXACT []
synonym: "oxo acid metabolic process" EXACT []
synonym: "oxo acid metabolism" EXACT []
synonym: "oxoacid metabolism" EXACT []
is_a: GO:0006082 ! organic acid metabolic process

[Term]
id: GO:0043438
name: acetoacetic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving acetoacetic acid, 3-oxobutanoic acid; the empirical formula is C4H6O3 or CH3COCH2COOH." [CHEBI:15344, Wikipedia:Acetoacetic_acid]
synonym: "3-oxobutanoate metabolic process" EXACT []
synonym: "3-oxobutanoate metabolism" EXACT []
synonym: "3-oxobutanoic acid metabolic process" EXACT []
synonym: "3-oxobutanoic acid metabolism" EXACT []
synonym: "acetoacetate metabolic process" EXACT []
synonym: "acetoacetate metabolism" EXACT []
synonym: "acetoacetic acid metabolism" EXACT []
synonym: "beta ketobutyric acid metabolic process" EXACT []
synonym: "beta ketobutyric acid metabolism" EXACT []
synonym: "beta-ketobutyric acid metabolic process" EXACT []
synonym: "beta-ketobutyric acid metabolism" EXACT []
synonym: "diacetic acid metabolic process" EXACT []
synonym: "diacetic acid metabolism" EXACT []
is_a: GO:0046459 ! short-chain fatty acid metabolic process
is_a: GO:1902224 ! ketone body metabolic process

[Term]
id: GO:0043441
name: acetoacetic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of acetoacetic acid, a beta-keto acid of the keto acid group, empirical formula is C4H6O3 or CH3COCH2COOH." [GOC:jl]
synonym: "acetoacetic acid anabolism" EXACT []
synonym: "acetoacetic acid biosynthesis" EXACT []
synonym: "acetoacetic acid formation" EXACT []
synonym: "acetoacetic acid synthesis" EXACT []
is_a: GO:0043438 ! acetoacetic acid metabolic process
is_a: GO:0046951 ! ketone body biosynthetic process
is_a: GO:0051790 ! short-chain fatty acid biosynthetic process

[Term]
id: GO:0043442
name: acetoacetic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of acetoacetic acid, a beta-keto acid of the keto acid group, empirical formula is C4H6O3 or CH3COCH2COOH." [GOC:jl]
synonym: "acetoacetic acid breakdown" EXACT []
synonym: "acetoacetic acid catabolism" EXACT []
synonym: "acetoacetic acid degradation" EXACT []
is_a: GO:0019626 ! short-chain fatty acid catabolic process
is_a: GO:0043438 ! acetoacetic acid metabolic process
is_a: GO:0046952 ! ketone body catabolic process

[Term]
id: GO:0043443
name: acetone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving acetone, propan-2-one." [GOC:jl]
synonym: "2-propanone metabolic process" EXACT []
synonym: "2-propanone metabolism" EXACT []
synonym: "acetone metabolism" EXACT []
synonym: "dimethyl ketone metabolic process" EXACT []
synonym: "dimethyl ketone metabolism" EXACT []
synonym: "propan-2-one metabolic process" EXACT []
synonym: "propan-2-one metabolism" EXACT []
is_a: GO:0042180 ! cellular ketone metabolic process
is_a: GO:1902224 ! ketone body metabolic process

[Term]
id: GO:0043444
name: acetone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of acetone, propan-2-one." [GOC:jl]
synonym: "2-propanone catabolic process" EXACT []
synonym: "2-propanone catabolism" EXACT []
synonym: "acetone breakdown" EXACT []
synonym: "acetone catabolism" EXACT []
synonym: "acetone degradation" EXACT []
synonym: "dimethyl ketone catabolic process" EXACT []
synonym: "dimethyl ketone catabolism" EXACT []
synonym: "propan-2-one catabolic process" EXACT []
synonym: "propan-2-one catabolism" EXACT []
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:0043443 ! acetone metabolic process
is_a: GO:0046952 ! ketone body catabolic process

[Term]
id: GO:0043445
name: acetone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of acetone, propan-2-one." [GOC:jl]
synonym: "2-propanone biosynthesis" EXACT []
synonym: "2-propanone biosynthetic process" EXACT []
synonym: "acetone anabolism" EXACT []
synonym: "acetone biosynthesis" EXACT []
synonym: "acetone formation" EXACT []
synonym: "acetone synthesis" EXACT []
synonym: "dimethyl ketone biosynthesis" EXACT []
synonym: "dimethyl ketone biosynthetic process" EXACT []
synonym: "propan-2-one biosynthesis" EXACT []
synonym: "propan-2-one biosynthetic process" EXACT []
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0043443 ! acetone metabolic process
is_a: GO:0046951 ! ketone body biosynthetic process

[Term]
id: GO:0043446
name: cellular alkane metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an alkane, any acyclic branched or unbranched hydrocarbon having the general formula CnH2n+2, as carried out by individual cells." [CHEBI:18310, GOC:jl, Wikipedia:Alkane]
subset: goslim_pir
subset: gosubset_prok
synonym: "alkane metabolism" EXACT []
is_a: GO:0044237 ! cellular metabolic process
is_a: GO:0044710 ! single-organism metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0071704 ! organic substance metabolic process

[Term]
id: GO:0043447
name: alkane biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an alkane, any acyclic branched or unbranched hydrocarbon having the general formula CnH2n+2." [CHEBI:18310, GOC:jl, Wikipedia:Alkane]
subset: gosubset_prok
synonym: "alkane anabolism" EXACT []
synonym: "alkane biosynthesis" EXACT []
synonym: "alkane formation" EXACT []
synonym: "alkane synthesis" EXACT []
is_a: GO:0043446 ! cellular alkane metabolic process
is_a: GO:0044249 ! cellular biosynthetic process
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:1901576 ! organic substance biosynthetic process

[Term]
id: GO:0043448
name: alkane catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of an alkane, any acyclic branched or unbranched hydrocarbon having the general formula CnH2n+2." [CHEBI:18310, GOC:jl, Wikipedia:Alkane]
subset: gosubset_prok
synonym: "alkane breakdown" EXACT []
synonym: "alkane catabolism" EXACT []
synonym: "alkane degradation" EXACT []
is_a: GO:0043446 ! cellular alkane metabolic process
is_a: GO:0044248 ! cellular catabolic process
is_a: GO:0044712 ! single-organism catabolic process
is_a: GO:1901575 ! organic substance catabolic process

[Term]
id: GO:0043449
name: cellular alkene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an alkene, any acyclic branched or unbranched hydrocarbon having one carbon-carbon double bond and the general formula CnH2n, as carried out by individual cells." [CHEBI:32878, GOC:jl, Wikipedia:Alkene]
subset: goslim_pir
subset: gosubset_prok
synonym: "alkene metabolism" EXACT []
is_a: GO:0044237 ! cellular metabolic process
is_a: GO:1900673 ! olefin metabolic process

[Term]
id: GO:0043450
name: alkene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an alkene, any acyclic branched or unbranched hydrocarbon having one carbon-carbon double bond and the general formula CnH2n." [CHEBI:32878, GOC:jl, Wikipedia:Alkene]
subset: gosubset_prok
synonym: "alkene anabolism" EXACT []
synonym: "alkene biosynthesis" EXACT []
synonym: "alkene formation" EXACT []
synonym: "alkene synthesis" EXACT []
is_a: GO:0043449 ! cellular alkene metabolic process
is_a: GO:0044249 ! cellular biosynthetic process
is_a: GO:1900674 ! olefin biosynthetic process

[Term]
id: GO:0043451
name: alkene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of an alkene, any acyclic branched or unbranched hydrocarbon having one carbon-carbon double bond and the general formula CnH2n." [CHEBI:32878, GOC:jl, Wikipedia:Alkene]
subset: gosubset_prok
synonym: "alkene breakdown" EXACT []
synonym: "alkene catabolism" EXACT []
synonym: "alkene degradation" EXACT []
is_a: GO:0043449 ! cellular alkene metabolic process
is_a: GO:0044248 ! cellular catabolic process
is_a: GO:1901575 ! organic substance catabolic process

[Term]
id: GO:0043452
name: cellular alkyne metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an alkyne, any cyclic branched or unbranched hydrocarbon having a carbon-carbon triple bond and the general formula CnH2n-2, as carried out by individual cells." [CHEBI:22339, GOC:jl, Wikipedia:Alkyne]
subset: goslim_pir
subset: gosubset_prok
synonym: "alkyne metabolism" EXACT []
is_a: GO:0044237 ! cellular metabolic process
is_a: GO:0044710 ! single-organism metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0071704 ! organic substance metabolic process

[Term]
id: GO:0043453
name: alkyne biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an alkyne, any cyclic branched or unbranched hydrocarbon having a carbon-carbon triple bond and the general formula CnH2n-2." [CHEBI:22339, GOC:jl, Wikipedia:Alkyne]
synonym: "alkyne anabolism" EXACT []
synonym: "alkyne biosynthesis" EXACT []
synonym: "alkyne formation" EXACT []
synonym: "alkyne synthesis" EXACT []
is_a: GO:0043452 ! cellular alkyne metabolic process
is_a: GO:0044249 ! cellular biosynthetic process
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:1901576 ! organic substance biosynthetic process

[Term]
id: GO:0043454
name: alkyne catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of an alkyne, any cyclic branched or unbranched hydrocarbons having a carbon-carbon triple bond and the general formula CnH2n-2." [CHEBI:22339, GOC:jl, Wikipedia:Alkyne]
subset: gosubset_prok
synonym: "alkyne breakdown" EXACT []
synonym: "alkyne catabolism" EXACT []
synonym: "alkyne degradation" EXACT []
is_a: GO:0043452 ! cellular alkyne metabolic process
is_a: GO:0044248 ! cellular catabolic process
is_a: GO:0044712 ! single-organism catabolic process
is_a: GO:1901575 ! organic substance catabolic process

[Term]
id: GO:0043455
name: regulation of secondary metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of secondary metabolism, the chemical reactions and pathways involving compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon." [GOC:jl]
synonym: "regulation of secondary metabolism" EXACT []
is_a: GO:0019222 ! regulation of metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019748 ! secondary metabolic process
relationship: regulates GO:0019748 ! secondary metabolic process

[Term]
id: GO:0043456
name: regulation of pentose-phosphate shunt
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the pentose-phosphate shunt, the process in which glucose is oxidized, coupled to NADPH synthesis." [GOC:jl]
synonym: "regulation of pentose phosphate pathway" EXACT []
synonym: "regulation of pentose phosphate shunt" EXACT []
synonym: "regulation of pentose-phosphate pathway" EXACT []
is_a: GO:0010906 ! regulation of glucose metabolic process
is_a: GO:0034248 ! regulation of cellular amide metabolic process
is_a: GO:0043455 ! regulation of secondary metabolic process
is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process
is_a: GO:1902031 ! regulation of NADP metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006098 ! pentose-phosphate shunt
relationship: regulates GO:0006098 ! pentose-phosphate shunt

[Term]
id: GO:0043457
name: regulation of cellular respiration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular respiration, the enzymatic release of energy from organic compounds." [GOC:jl]
is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045333 ! cellular respiration
relationship: regulates GO:0045333 ! cellular respiration

[Term]
id: GO:0043458
name: ethanol biosynthetic process involved in glucose fermentation to ethanol
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ethanol, CH3-CH2-OH, as part of the process of glucose catabolism to ethanol, CO2 and ATP." [GOC:dph, GOC:jl, GOC:tb]
synonym: "ethanol anabolism during fermentation" RELATED []
synonym: "ethanol formation during fermentation" RELATED []
synonym: "ethanol synthesis during fermentation" RELATED []
is_a: GO:0006115 ! ethanol biosynthetic process
intersection_of: GO:0006115 ! ethanol biosynthetic process
intersection_of: part_of GO:0019655 ! glycolytic fermentation to ethanol
relationship: part_of GO:0019655 ! glycolytic fermentation to ethanol

[Term]
id: GO:0043459
name: obsolete response to short exposure to lithium ion
namespace: biological_process
def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a single or short exposure to a lithium ion stimulus." [PMID:10208444]
comment: This term was made obsolete because 'short' is not a quantitative or meaningful measurement of time.
synonym: "response to short exposure to lithium ion" EXACT []
is_obsolete: true

[Term]
id: GO:0043460
name: obsolete response to long exposure to lithium ion
namespace: biological_process
def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a long or persistent exposure to a lithium ion stimulus." [PMID:10208444]
comment: This term was made obsolete because 'long' is not a quantitative or meaningful measurement of time.
synonym: "response to long exposure to lithium ion" EXACT []
is_obsolete: true

[Term]
id: GO:0043461
name: proton-transporting ATP synthase complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a proton-transporting ATP synthase (also known as F-type ATPase), a two-sector ATPase found in the inner membrane of mitochondria and chloroplasts, and in bacterial plasma membranes." [GOC:jl, GOC:mah, http://www.mblab.gla.ac.uk/]
subset: gosubset_prok
synonym: "F-type ATPase complex assembly" EXACT []
is_a: GO:0070071 ! proton-transporting two-sector ATPase complex assembly
relationship: part_of GO:0070272 ! proton-transporting ATP synthase complex biogenesis

[Term]
id: GO:0043462
name: regulation of ATPase activity
namespace: biological_process
def: "Any process that modulates the rate of ATP hydrolysis by an ATPase." [GOC:jl]
synonym: "regulation of adenosinetriphosphatase activity" EXACT []
is_a: GO:0051336 ! regulation of hydrolase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016887 ! ATPase activity
relationship: regulates GO:0016887 ! ATPase activity

[Term]
id: GO:0043463
name: regulation of rhamnose catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of rhamnose, the hexose 6-deoxy-L-mannose." [GOC:jl]
synonym: "regulation of rhamnose breakdown" EXACT []
synonym: "regulation of rhamnose catabolism" EXACT []
synonym: "regulation of rhamnose degradation" EXACT []
is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019301 ! rhamnose catabolic process
relationship: regulates GO:0019301 ! rhamnose catabolic process

[Term]
id: GO:0043464
name: malolactic fermentation
namespace: biological_process
def: "The anaerobic enzymatic conversion of L-malate to L-lactate and carbon dioxide, yielding energy in the form of ATP." [PMID:10427020, PMID:8808948]
synonym: "L-malate fermentation" BROAD []
synonym: "malate fermentation" BROAD []
synonym: "malo-lactate fermentation" EXACT []
synonym: "malolactate fermentation" EXACT []
xref: Wikipedia:Malolactic_fermentation
is_a: GO:0006113 ! fermentation

[Term]
id: GO:0043465
name: regulation of fermentation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fermentation, the anaerobic enzymatic conversion of organic compounds, especially carbohydrates, to other compounds, especially to ethyl alcohol, resulting in energy in the form of adenosine triphosphate (ATP)." [GOC:jl]
is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006113 ! fermentation
relationship: regulates GO:0006113 ! fermentation

[Term]
id: GO:0043466
name: pyrimidine nucleobase fermentation
namespace: biological_process
def: "The anaerobic conversion of pyrimidine nucleobases, yielding energy in the form of ATP." [CHEBI:26432, GOC:jl]
synonym: "pyrimidine base fermentation" EXACT [GOC:go_curators]
synonym: "pyrimidine fermentation" RELATED [GOC:curators]
is_a: GO:0006208 ! pyrimidine nucleobase catabolic process
is_a: GO:0019666 ! nitrogenous compound fermentation

[Term]
id: GO:0043467
name: regulation of generation of precursor metabolites and energy
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances." [GOC:jl]
is_a: GO:0031323 ! regulation of cellular metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006091 ! generation of precursor metabolites and energy
relationship: regulates GO:0006091 ! generation of precursor metabolites and energy

[Term]
id: GO:0043468
name: regulation of fucose catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of fucose." [GOC:mlg]
is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019317 ! fucose catabolic process
relationship: regulates GO:0019317 ! fucose catabolic process

[Term]
id: GO:0043469
name: regulation of D-xylose catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of xylose." [GOC:mlg]
is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042843 ! D-xylose catabolic process
relationship: regulates GO:0042843 ! D-xylose catabolic process

[Term]
id: GO:0043470
name: regulation of carbohydrate catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates." [GOC:mlg]
subset: gosubset_prok
is_a: GO:0006109 ! regulation of carbohydrate metabolic process
is_a: GO:0009894 ! regulation of catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016052 ! carbohydrate catabolic process
relationship: regulates GO:0016052 ! carbohydrate catabolic process

[Term]
id: GO:0043471
name: regulation of cellular carbohydrate catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates, carried out by individual cells." [GOC:jl]
subset: gosubset_prok
is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process
is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:0043470 ! regulation of carbohydrate catabolic process
is_a: GO:0060255 ! regulation of macromolecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044275 ! cellular carbohydrate catabolic process
relationship: regulates GO:0044275 ! cellular carbohydrate catabolic process

[Term]
id: GO:0043472
name: IgD binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an immunoglobulin of a D isotype." [PMID:12886015]
is_a: GO:0019865 ! immunoglobulin binding

[Term]
id: GO:0043473
name: pigmentation
namespace: biological_process
def: "The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells." [GOC:jl]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0044699 ! single-organism process

[Term]
id: GO:0043474
name: pigment metabolic process involved in pigmentation
namespace: biological_process
def: "The chemical reactions and pathways involving a pigment, any general or particular coloring matter in living organisms, resulting in the deposition or aggregation of pigment in an organism, tissue or cell." [GOC:dph, GOC:jl, GOC:tb]
synonym: "pigment metabolic process during pigmentation" RELATED [GOC:dph, GOC:tb]
synonym: "pigment metabolism during pigmentation" RELATED []
is_a: GO:0042440 ! pigment metabolic process
intersection_of: GO:0042440 ! pigment metabolic process
intersection_of: part_of GO:0043473 ! pigmentation
relationship: part_of GO:0043473 ! pigmentation

[Term]
id: GO:0043475
name: pigment metabolic process involved in pigment accumulation
namespace: biological_process
def: "The chemical reactions and pathways involving a pigment, any general or particular coloring matter in living organisms, as part of the accumulation of pigment." [GOC:jl]
synonym: "pigment metabolic process during pigment accumulation" RELATED [GOC:dph, GOC:tb]
synonym: "pigment metabolism during pigment accumulation" RELATED []
is_a: GO:0043474 ! pigment metabolic process involved in pigmentation
intersection_of: GO:0042440 ! pigment metabolic process
intersection_of: part_of GO:0043476 ! pigment accumulation
relationship: part_of GO:0043476 ! pigment accumulation

[Term]
id: GO:0043476
name: pigment accumulation
namespace: biological_process
def: "The aggregation of coloring matter in a particular location in an organism, tissue or cell, occurring in response to some external stimulus." [GOC:jl]
synonym: "pigment accumulation in response to external stimulus" EXACT []
is_a: GO:0009605 ! response to external stimulus
is_a: GO:0043473 ! pigmentation

[Term]
id: GO:0043477
name: pigment biosynthetic process involved in pigment accumulation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, resulting in pigment accumulation." [GOC:dph, GOC:jl, GOC:tb]
synonym: "pigment biosynthetic process during pigment accumulation" RELATED [GOC:dph, GOC:tb]
is_a: GO:0043475 ! pigment metabolic process involved in pigment accumulation
is_a: GO:0046148 ! pigment biosynthetic process
intersection_of: GO:0046148 ! pigment biosynthetic process
intersection_of: part_of GO:0043476 ! pigment accumulation
relationship: part_of GO:0043476 ! pigment accumulation

[Term]
id: GO:0043478
name: pigment accumulation in response to UV light
namespace: biological_process
def: "The aggregation of coloring matter in a particular location in an organism, tissue or cell, occurring in response to a UV light stimulus." [GOC:jl]
is_a: GO:0009411 ! response to UV
is_a: GO:0043476 ! pigment accumulation

[Term]
id: GO:0043479
name: pigment accumulation in tissues in response to UV light
namespace: biological_process
def: "The aggregation of coloring matter in a particular location in a tissue, occurring in response to a UV light stimulus." [GOC:jl]
is_a: GO:0043478 ! pigment accumulation in response to UV light
is_a: GO:0043480 ! pigment accumulation in tissues

[Term]
id: GO:0043480
name: pigment accumulation in tissues
namespace: biological_process
def: "The aggregation of coloring matter in a particular location in a tissue, occurring in response to an external stimulus." [GOC:jl]
synonym: "organismal pigment accumulation" EXACT []
is_a: GO:0043476 ! pigment accumulation
is_a: GO:0044707 ! single-multicellular organism process

[Term]
id: GO:0043481
name: anthocyanin accumulation in tissues in response to UV light
namespace: biological_process
def: "The aggregation of the pigment anthocyanin in a particular location in a tissue, occurring in response to a UV light stimulus." [GOC:jl]
is_a: GO:0043479 ! pigment accumulation in tissues in response to UV light

[Term]
id: GO:0043482
name: cellular pigment accumulation
namespace: biological_process
def: "The aggregation of coloring matter in a particular location in a cell, occurring in response to some external stimulus." [GOC:jl]
subset: gosubset_prok
is_a: GO:0033059 ! cellular pigmentation
is_a: GO:0043476 ! pigment accumulation
is_a: GO:0051716 ! cellular response to stimulus

[Term]
id: GO:0043483
name: anthocyanin biosynthetic process involved in anthocyanin accumulation in response to UV light
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the pigment anthocyanin, contributing to anthocyanin accumulation in a tissue in response to a UV light stimulus." [GOC:dph, GOC:jl, GOC:tb]
synonym: "anthocyanin biosynthesis during anthocyanin accumulation in tissues in response to UV light stimulus" RELATED []
synonym: "anthocyanin biosynthetic process during anthocyanin accumulation in response to UV light" RELATED [GOC:dph, GOC:tb]
synonym: "anthocyanin biosynthetic process during anthocyanin accumulation in tissues in response to UV light stimulus" RELATED []
is_a: GO:0009718 ! anthocyanin-containing compound biosynthetic process
is_a: GO:0043477 ! pigment biosynthetic process involved in pigment accumulation
intersection_of: GO:0009718 ! anthocyanin-containing compound biosynthetic process
intersection_of: part_of GO:0043481 ! anthocyanin accumulation in tissues in response to UV light
relationship: part_of GO:0043481 ! anthocyanin accumulation in tissues in response to UV light

[Term]
id: GO:0043484
name: regulation of RNA splicing
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]
is_a: GO:0010468 ! regulation of gene expression
is_a: GO:0051252 ! regulation of RNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008380 ! RNA splicing
relationship: regulates GO:0008380 ! RNA splicing

[Term]
id: GO:0043485
name: endosome to pigment granule transport
namespace: biological_process
def: "The directed movement of substances from endosomes to pigment granules." [GOC:jl]
is_a: GO:0016197 ! endosomal transport
relationship: part_of GO:0048757 ! pigment granule maturation

[Term]
id: GO:0043486
name: histone exchange
namespace: biological_process
def: "The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits." [GOC:jl, PMID:11735001, PMID:15066277]
comment: Note that this term also includes the exchange of sperm-specific histones or protamines with histones, occurring during spermatogenesis and fertilization.
synonym: "histone chaperone" RELATED [GOC:vw]
synonym: "histone replacement" EXACT []
is_a: GO:0034728 ! nucleosome organization
is_a: GO:0043044 ! ATP-dependent chromatin remodeling
relationship: has_part GO:0001207 ! histone displacement

[Term]
id: GO:0043487
name: regulation of RNA stability
namespace: biological_process
def: "Any process that modulates the propensity of RNA molecules to degradation. Includes processes that both stabilize and destabilize RNAs." [GOC:jl]
subset: gosubset_prok
is_a: GO:0010608 ! posttranscriptional regulation of gene expression
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0043488
name: regulation of mRNA stability
namespace: biological_process
def: "Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs." [GOC:jl]
subset: gosubset_prok
is_a: GO:0043487 ! regulation of RNA stability

[Term]
id: GO:0043489
name: RNA stabilization
namespace: biological_process
def: "Prevention of degradation of RNA molecules." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0043487 ! regulation of RNA stability

[Term]
id: GO:0043490
name: malate-aspartate shuttle
namespace: biological_process
def: "The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise malate in the cytosol; this compound is then transported into the mitochondria where it is converted to oxaloacetate using NADH, the oxaloacetate reacts with gluamate to form aspartate, and the aspartate then returns to the cytosol to complete the cycle." [GOC:jl, GOC:mtg_electron_transport, ISBN:0716743663]
synonym: "malate aspartate shuttle" EXACT []
synonym: "malate/aspartate shuttle" EXACT []
synonym: "malate:aspartate shuttle" EXACT []
xref: Wikipedia:Malate-aspartate_shuttle
is_a: GO:0006839 ! mitochondrial transport
relationship: part_of GO:0022904 ! respiratory electron transport chain

[Term]
id: GO:0043491
name: protein kinase B signaling
namespace: biological_process
def: "A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B (also called AKT), which occurs as a result of a single trigger reaction or compound." [GOC:bf, PMID:20517722]
synonym: "AKT signal transduction" EXACT [GOC:signaling]
synonym: "AKT signaling" EXACT [GOC:signaling]
synonym: "AKT signaling cascade" RELATED []
synonym: "AKT signalling cascade" EXACT []
synonym: "PKB signal transduction" EXACT [GOC:signaling]
synonym: "PKB signaling" EXACT [GOC:signaling]
synonym: "PKB signaling cascade" RELATED []
synonym: "PKB signalling cascade" RELATED []
synonym: "protein kinase B signal transduction" EXACT [GOC:signaling]
synonym: "protein kinase B signaling cascade" RELATED [GOC:signaling]
synonym: "protein kinase B signalling cascade" RELATED []
is_a: GO:0035556 ! intracellular signal transduction

[Term]
id: GO:0043492
name: ATPase activity, coupled to movement of substances
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance." [GOC:jl]
subset: gosubset_prok
is_a: GO:0042623 ! ATPase activity, coupled

[Term]
id: GO:0043493
name: viral terminase complex
namespace: cellular_component
def: "A complex of a large and small subunit which catalyze the packaging of DNA into viral heads. Note that not all viral terminases have this structure, some exist as single polypeptides." [GOC:bf, GOC:bm, GOC:jl, GOC:mlg]
synonym: "phage terminase complex" NARROW [GOC:bm]
is_a: GO:0043234 ! protein complex
is_a: GO:0044423 ! virion part

[Term]
id: GO:0043494
name: CLRC ubiquitin ligase complex
namespace: cellular_component
def: "An cullin-dependent E3 ubiquitin ligase/histone H3-K9 methyltransferase complex essential for heterochromatin assembly by RNAi." [GOC:vw, PMID:16127433, PMID:20211136]
synonym: "Clr4-Rik1-Cul4 complex" EXACT []
synonym: "CLRC complex" EXACT []
synonym: "Rik1 E3 ubiquitin ligase complex" EXACT []
synonym: "Rik1-E3 ubiquitin ligase complex" EXACT []
is_a: GO:0000152 ! nuclear ubiquitin ligase complex
is_a: GO:0031465 ! Cul4B-RING E3 ubiquitin ligase complex
is_a: GO:0035097 ! histone methyltransferase complex

[Term]
id: GO:0043495
name: protein anchor
namespace: molecular_function
def: "Interacting selectively and non-covalently with both a protein or protein complex and a membrane, in order to maintain the localization of the protein at a specific location on the membrane." [GOC:go_curators]
synonym: "anchoring" RELATED []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0043496
name: regulation of protein homodimerization activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer." [GOC:jl, GOC:tb]
comment: Note that protein homodimerization is a molecular function: 'protein homodimerization activity ; GO:0042803'.
is_a: GO:0043393 ! regulation of protein binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042803 ! protein homodimerization activity
relationship: regulates GO:0042803 ! protein homodimerization activity

[Term]
id: GO:0043497
name: regulation of protein heterodimerization activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein heterodimerization, interacting selectively with a nonidentical protein to form a heterodimer." [GOC:jl, GOC:tb]
comment: Note that protein heterodimerization is a molecular function: 'protein heterodimerization activity ; GO:0046982'.
is_a: GO:0043393 ! regulation of protein binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0046982 ! protein heterodimerization activity
relationship: regulates GO:0046982 ! protein heterodimerization activity

[Term]
id: GO:0043498
name: obsolete cell surface binding
namespace: molecular_function
def: "OBSOLETE. Interacting selectively and non-covalently with any component on the surface of a cell." [GOC:jl]
comment: This term was made obsolete because it is ambiguous and causing confusion, and is an unnecessary grouping term.
subset: goslim_pir
subset: gosubset_prok
synonym: "cell surface binding" EXACT []
is_obsolete: true
consider: GO:0003823
consider: GO:0005102
consider: GO:0007155
consider: GO:0009986
consider: GO:0046812

[Term]
id: GO:0043499
name: obsolete eukaryotic cell surface binding
namespace: molecular_function
def: "OBSOLETE. Interacting selectively and non-covalently with any component on the surface of a eukaryotic cell." [GOC:jl]
comment: This term was made obsolete because it is ambiguous and causing confusion, and is an unnecessary grouping term.
synonym: "eukaryotic cell surface binding" EXACT []
is_obsolete: true
consider: GO:0003823
consider: GO:0005102
consider: GO:0006952
consider: GO:0009986
consider: GO:0046812

[Term]
id: GO:0043500
name: muscle adaptation
namespace: biological_process
def: "A process in which muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle, PMID:11181628, PMID:11449884, PMID:12605307]
subset: goslim_pir
synonym: "muscle plasticity" RELATED []
is_a: GO:0003012 ! muscle system process
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0043501
name: skeletal muscle adaptation
namespace: biological_process
def: "Any process in which skeletal muscles change their phenotypic profiles in response to altered functional demands and a variety of signals." [GOC:mtg_muscle, PMID:11181628, PMID:11449884, PMID:12605307]
synonym: "skeletal muscle plasticity" RELATED []
is_a: GO:0014888 ! striated muscle adaptation

[Term]
id: GO:0043502
name: regulation of muscle adaptation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of muscle adaptation." [GOC:go_curators, GOC:mtg_muscle]
synonym: "regulation of muscle plasticity" RELATED []
is_a: GO:0048583 ! regulation of response to stimulus
is_a: GO:0090257 ! regulation of muscle system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043500 ! muscle adaptation
relationship: regulates GO:0043500 ! muscle adaptation

[Term]
id: GO:0043503
name: skeletal muscle fiber adaptation
namespace: biological_process
def: "Any process in which the skeletal muscle fibers change their phenotypic profiles in response to altered functional demands and a variety of signals. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:mtg_muscle, PMID:11181628, PMID:11449884, PMID:12605307]
synonym: "skeletal muscle fiber plasticity" RELATED []
synonym: "skeletal muscle fibre plasticity" EXACT []
synonym: "skeletal myofiber plasticity" EXACT []
synonym: "skeletal myofibre plasticity" EXACT []
is_a: GO:0051716 ! cellular response to stimulus
relationship: part_of GO:0043501 ! skeletal muscle adaptation

[Term]
id: GO:0043504
name: mitochondrial DNA repair
namespace: biological_process
def: "The process of restoring mitochondrial DNA after damage." [PMID:12565799, PMID:15189144, PMID:16050976]
is_a: GO:0006281 ! DNA repair
is_a: GO:0032042 ! mitochondrial DNA metabolic process
intersection_of: GO:0006281 ! DNA repair
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion

[Term]
id: GO:0043505
name: CENP-A containing nucleosome
namespace: cellular_component
def: "A form of nucleosome located only at the centromere, in which the histone H3 is replaced by the variant form CENP-A (sometimes known as CenH3)." [GOC:go_curators, PMID:15175412, PMID:16183641]
synonym: "centromere specific nucleosome" RELATED []
synonym: "centromere-specific nucleosome" RELATED [GOC:vw]
synonym: "centromeric nucleosome" RELATED []
is_a: GO:0000786 ! nucleosome
relationship: part_of GO:0000775 ! chromosome, centromeric region
relationship: part_of GO:0061638 ! CENP-A containing chromatin

[Term]
id: GO:0043506
name: regulation of JUN kinase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of JUN kinase activity." [GOC:jl]
synonym: "regulation of JUNK activity" EXACT []
is_a: GO:0043405 ! regulation of MAP kinase activity
is_a: GO:0046328 ! regulation of JNK cascade
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004705 ! JUN kinase activity
relationship: regulates GO:0004705 ! JUN kinase activity

[Term]
id: GO:0043507
name: positive regulation of JUN kinase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of JUN kinase activity." [GOC:jl]
synonym: "positive regulation of JUNK activity" EXACT []
synonym: "stimulation of JNK activity" NARROW []
synonym: "up regulation of JNK activity" EXACT []
synonym: "up-regulation of JNK activity" EXACT []
synonym: "upregulation of JNK activity" EXACT []
is_a: GO:0043406 ! positive regulation of MAP kinase activity
is_a: GO:0043506 ! regulation of JUN kinase activity
is_a: GO:0046330 ! positive regulation of JNK cascade
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004705 ! JUN kinase activity
relationship: positively_regulates GO:0004705 ! JUN kinase activity

[Term]
id: GO:0043508
name: negative regulation of JUN kinase activity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of JUN kinase activity." [GOC:jl]
synonym: "down regulation of JNK activity" EXACT []
synonym: "down-regulation of JNK activity" EXACT []
synonym: "downregulation of JNK activity" EXACT []
synonym: "inhibition of JNK activity" NARROW []
synonym: "negative regulation of JUNK activity" EXACT []
is_a: GO:0043407 ! negative regulation of MAP kinase activity
is_a: GO:0043506 ! regulation of JUN kinase activity
is_a: GO:0046329 ! negative regulation of JNK cascade
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004705 ! JUN kinase activity
relationship: negatively_regulates GO:0004705 ! JUN kinase activity

[Term]
id: GO:0043509
name: activin A complex
namespace: cellular_component
alt_id: GO:0048181
def: "A nonsteroidal regulator, composed of two covalently linked inhibin beta-A subunits (sometimes known as activin beta-A or activin/inhibin beta-A)." [GOC:go_curators]
comment: Note that the actions of the activin complex are the opposite of those of the inhibin complex, which is a dimer of an inhibin beta-A or inhibin beta-B subunit and an inhibin alpha subunit. See also the cellular component term 'inhibin complex ; GO:0043511'.
is_a: GO:0048180 ! activin complex

[Term]
id: GO:0043510
name: activin B complex
namespace: cellular_component
alt_id: GO:0048182
def: "A nonsteroidal regulator, composed of two covalently linked inhibin beta-B subunits (sometimes known as activin beta-B or activin/inhibin beta-B)." [GOC:go_curators]
comment: Note that the actions of the activin complex are the opposite of those of the inhibin complex, which is a dimer of an inhibin beta-A or inhibin beta-B subunit and a inhibin alpha subunit. See 'inhibin complex ; GO:0043511'.
is_a: GO:0048180 ! activin complex

[Term]
id: GO:0043511
name: inhibin complex
namespace: cellular_component
def: "Heterodimeric hormone composed of an inhibin alpha subunit complexed with either an inhibin beta-A subunit, to form inhibin A, or an inhibin beta-B subunit, to form inhibin B." [GOC:jl]
comment: Note that the actions of the inhibin complex are the opposite of those of the activin complex, which is a dimer of an inhibin beta-A and/or inhibin beta-B subunit. See also the cellular component term 'activin complex ; GO:0048180'.
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0043512
name: inhibin A complex
namespace: cellular_component
def: "Heterodimeric hormone composed of an inhibin alpha subunit complexed with an inhibin beta-A subunit." [GOC:jl]
comment: Note that the actions of the inhibin complex are the opposite of those of the activin complex, which is a dimer of an inhibin beta-A and/or inhibin beta-B subunit. See also the cellular component term 'activin complex ; GO:0048180'.
is_a: GO:0043511 ! inhibin complex

[Term]
id: GO:0043513
name: inhibin B complex
namespace: cellular_component
def: "Heterodimeric hormone composed of an inhibin alpha subunit complexed with an inhibin beta-B subunit." [GOC:jl]
comment: Note that the actions of the inhibin complex are the opposite of those of the activin complex, which is a dimer of an inhibin beta-A and/or inhibin beta-B subunit. See also the cellular component term 'activin complex ; GO:0048180'.
is_a: GO:0043511 ! inhibin complex

[Term]
id: GO:0043514
name: interleukin-12 complex
namespace: cellular_component
def: "A protein complex that is composed of an interleukin-12 alpha (p35, product of the IL12A gene) and an interleukin-12 beta subunit (p40, product of the IL12B gene) and is secreted into the extracellular space." [GOC:add, GOC:ebc, GOC:mah, PMID:12948519, PMID:1381512]
comment: Note that this heterodimeric cytokine utilizes the IL-12p35 subunit as its alpha chain, which is also used by IL-35 as its alpha chain, and utilizes the IL-12p40 subunit as its beta chain, which is also used by IL-23 as its beta chain.
synonym: "IL-12 complex" EXACT [GOC:mah]
synonym: "IL12A" NARROW [GOC:add]
synonym: "IL12B" NARROW [GOC:add]
synonym: "p35" NARROW [GOC:add]
synonym: "p40" NARROW [GOC:add]
is_a: GO:0043234 ! protein complex
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0043515
name: kinetochore binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a kinetochore, a proteinaceous structure on a condensed chromosome, beside the centromere, to which the spindle fibers are attached." [GOC:jl, http://www.mercksource.com/]
is_a: GO:0032403 ! protein complex binding

[Term]
id: GO:0043516
name: regulation of DNA damage response, signal transduction by p53 class mediator
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage." [GOC:jl]
synonym: "regulation of p53 induced by DNA damage response" EXACT []
is_a: GO:1901796 ! regulation of signal transduction by p53 class mediator
is_a: GO:2001020 ! regulation of response to DNA damage stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030330 ! DNA damage response, signal transduction by p53 class mediator
relationship: regulates GO:0030330 ! DNA damage response, signal transduction by p53 class mediator

[Term]
id: GO:0043517
name: positive regulation of DNA damage response, signal transduction by p53 class mediator
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage." [GOC:jl]
synonym: "activation of DNA damage response, signal transduction by p53 class mediator" NARROW []
synonym: "positive regulation of p53 induced by DNA damage response" EXACT []
synonym: "stimulation of DNA damage response, signal transduction by p53 class mediator" NARROW []
synonym: "up regulation of DNA damage response, signal transduction by p53 class mediator" EXACT []
synonym: "up-regulation of DNA damage response, signal transduction by p53 class mediator" EXACT []
synonym: "upregulation of DNA damage response, signal transduction by p53 class mediator" EXACT []
is_a: GO:0043516 ! regulation of DNA damage response, signal transduction by p53 class mediator
is_a: GO:1901798 ! positive regulation of signal transduction by p53 class mediator
is_a: GO:2001022 ! positive regulation of response to DNA damage stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030330 ! DNA damage response, signal transduction by p53 class mediator
relationship: positively_regulates GO:0030330 ! DNA damage response, signal transduction by p53 class mediator

[Term]
id: GO:0043518
name: negative regulation of DNA damage response, signal transduction by p53 class mediator
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage." [GOC:jl]
synonym: "down regulation of DNA damage response, signal transduction by p53 class mediator" EXACT []
synonym: "down-regulation of DNA damage response, signal transduction by p53 class mediator" EXACT []
synonym: "downregulation of DNA damage response, signal transduction by p53 class mediator" EXACT []
synonym: "inhibition of DNA damage response, signal transduction by p53 class mediator" NARROW []
synonym: "negative regulation of p53 induced by DNA damage response" EXACT []
is_a: GO:0043516 ! regulation of DNA damage response, signal transduction by p53 class mediator
is_a: GO:1901797 ! negative regulation of signal transduction by p53 class mediator
is_a: GO:2001021 ! negative regulation of response to DNA damage stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030330 ! DNA damage response, signal transduction by p53 class mediator
relationship: negatively_regulates GO:0030330 ! DNA damage response, signal transduction by p53 class mediator

[Term]
id: GO:0043519
name: regulation of myosin II filament organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the assembly, arrangement of constituent parts, or disassembly of a bipolar filament composed of myosin II molecules." [GOC:jl]
synonym: "regulation of myosin II filament assembly or disassembly" RELATED [GOC:mah]
synonym: "regulation of myosin II filament organisation" EXACT [GOC:mah]
is_a: GO:0032956 ! regulation of actin cytoskeleton organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031038 ! myosin II filament organization
relationship: regulates GO:0031038 ! myosin II filament organization

[Term]
id: GO:0043520
name: regulation of myosin II filament assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the formation of a bipolar filament composed of myosin II molecules." [GOC:jl]
is_a: GO:0043254 ! regulation of protein complex assembly
is_a: GO:0043519 ! regulation of myosin II filament organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031036 ! myosin II filament assembly
relationship: regulates GO:0031036 ! myosin II filament assembly

[Term]
id: GO:0043521
name: regulation of myosin II filament disassembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the disassembly of a bipolar filament composed of myosin II molecules." [GOC:jl]
is_a: GO:0043244 ! regulation of protein complex disassembly
is_a: GO:0043519 ! regulation of myosin II filament organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031037 ! myosin II filament disassembly
relationship: regulates GO:0031037 ! myosin II filament disassembly

[Term]
id: GO:0043522
name: leucine zipper domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a leucine zipper domain, a protein secondary structure exhibiting a periodic repetition of leucine residues at every seventh position over a distance covering eight helical turns." [GOC:jl, InterPro:IPR002158]
synonym: "leucine zipper binding" EXACT []
is_a: GO:0030275 ! LRR domain binding

[Term]
id: GO:0043523
name: regulation of neuron apoptotic process
namespace: biological_process
def: "Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons." [GOC:go_curators, GOC:mtg_apoptosis]
synonym: "regulation of apoptosis of neuronal cells" EXACT []
synonym: "regulation of apoptosis of neurons" EXACT []
synonym: "regulation of neuron apoptosis" NARROW []
synonym: "regulation of neuron programmed cell death" EXACT []
synonym: "regulation of neuronal cell programmed cell death" EXACT []
synonym: "regulation of programmed cell death of neuronal cells" EXACT []
synonym: "regulation of programmed cell death, neurons" EXACT []
is_a: GO:0042981 ! regulation of apoptotic process
is_a: GO:1901214 ! regulation of neuron death
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051402 ! neuron apoptotic process
relationship: regulates GO:0051402 ! neuron apoptotic process

[Term]
id: GO:0043524
name: negative regulation of neuron apoptotic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons." [GOC:go_curators, GOC:mtg_apoptosis]
synonym: "down regulation of neuron apoptosis" EXACT []
synonym: "down-regulation of neuron apoptosis" EXACT []
synonym: "downregulation of neuron apoptosis" EXACT []
synonym: "inhibition of neuron apoptosis" NARROW []
synonym: "negative regulation of neuron apoptosis" NARROW []
synonym: "negative regulation of programmed cell death, neurons" EXACT []
synonym: "neuron survival" NARROW []
is_a: GO:0043066 ! negative regulation of apoptotic process
is_a: GO:0043523 ! regulation of neuron apoptotic process
is_a: GO:1901215 ! negative regulation of neuron death
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051402 ! neuron apoptotic process
relationship: negatively_regulates GO:0051402 ! neuron apoptotic process

[Term]
id: GO:0043525
name: positive regulation of neuron apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process." [GOC:go_curators, GOC:mtg_apoptosis]
synonym: "activation of neuron apoptosis" NARROW []
synonym: "positive regulation of neuron apoptosis" NARROW []
synonym: "positive regulation of programmed cell death, neurons" EXACT []
synonym: "stimulation of neuron apoptosis" NARROW []
synonym: "up regulation of neuron apoptosis" EXACT []
synonym: "up-regulation of neuron apoptosis" EXACT []
synonym: "upregulation of neuron apoptosis" EXACT []
is_a: GO:0043065 ! positive regulation of apoptotic process
is_a: GO:0043523 ! regulation of neuron apoptotic process
is_a: GO:1901216 ! positive regulation of neuron death
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051402 ! neuron apoptotic process
relationship: positively_regulates GO:0051402 ! neuron apoptotic process

[Term]
id: GO:0043526
name: obsolete neuroprotection
namespace: biological_process
def: "OBSOLETE. Any process that modulates the occurrence or rate of cell death by apoptosis in the nervous system. It may stop or prevent or reduce the rate of cell death by apoptosis and it is activated by stress to counteract death signals in central nervous systems. Different neuroprotective mechanisms may be activated to combat distinct types of cellular stress, ERK pathway is one of several neuroprotective mechanisms and it is a model system to study neuronal apoptosis, which may contribute to several neurodegenerative diseases and aging-related neuron loss." [GOC:mtg_apoptosis, MSH:D017209, PMID:10208444, PMID:11909981, PMID:15905876]
comment: This term was made obsolete because it refers to assays rather than processes. If neuron death by apoptosis is assessed, consider using GO:0043523 regulation of neuron apoptotic process. If neuron death is assessed but the cell death modality isn't defined, refer to GO:0070997 neuron death. Where non-neuronal cells are involved, and/or processes other than cell death are described, please use other terms for annotation.
synonym: "neuroprotection" EXACT []
xref: Wikipedia:Neuroprotection
is_obsolete: true

[Term]
id: GO:0043527
name: tRNA methyltransferase complex
namespace: cellular_component
def: "A multimeric protein complex involved in the methylation of specific nucleotides in tRNA." [GOC:jl]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0034708 ! methyltransferase complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0043528
name: tRNA (m2G10) methyltransferase complex
namespace: cellular_component
def: "A protein complex required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNA. In S. cerevisiae, this complex consists of at least two subunits, Trm11p and Trm112p." [PMID:15899842]
is_a: GO:0043527 ! tRNA methyltransferase complex

[Term]
id: GO:0043529
name: GET complex
namespace: cellular_component
def: "A multisubunit complex involved in ER/Golgi trafficking (Golgi to ER Traffic). In yeast, includes Get1p, Get2p and Get3p proteins." [PMID:16269340]
synonym: "Golgi to ER Traffic complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044432 ! endoplasmic reticulum part

[Term]
id: GO:0043530
name: adenosine 5'-monophosphoramidase activity
namespace: molecular_function
def: "Catalysis of the reaction: adenosine 5'-monophosphoramidate = AMP + NH2. Other substrates include AMP-morpholidate, AMP-N-alanine methyl ester and AMP-alpha-acetyl lysine methyl ester." [PMID:11805111]
synonym: "adenosine 5' monophosphoramidase activity" EXACT []
synonym: "adenosine 5'-monophosphoramidate hydrolase activity" EXACT []
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0043531
name: ADP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with ADP, adenosine 5'-diphosphate." [GOC:jl]
synonym: "adenosine 5'-diphosphate binding" EXACT []
synonym: "adenosine diphosphate binding" EXACT []
is_a: GO:0032550 ! purine ribonucleoside binding
is_a: GO:0032559 ! adenyl ribonucleotide binding
is_a: GO:0043168 ! anion binding

[Term]
id: GO:0043532
name: angiostatin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with angiostatin, a proteolytic product of plasminogen or plasmin containing at least one intact kringle domain, and which is an inhibitor of angiogenesis." [PMID:16043488]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0043533
name: inositol 1,3,4,5 tetrakisphosphate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with inositol 1,3,4,5 tetrakisphosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "InsP4 binding" EXACT []
synonym: "IP4 binding" EXACT []
is_a: GO:0043168 ! anion binding
is_a: GO:0043178 ! alcohol binding

[Term]
id: GO:0043534
name: blood vessel endothelial cell migration
namespace: biological_process
def: "The orderly movement of an endothelial cell into the extracellular matrix in order to form new blood vessels during angiogenesis." [PMID:11166264]
is_a: GO:0043542 ! endothelial cell migration

[Term]
id: GO:0043535
name: regulation of blood vessel endothelial cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the migration of the endothelial cells of blood vessels." [GOC:go_curators]
is_a: GO:0010594 ! regulation of endothelial cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043534 ! blood vessel endothelial cell migration
relationship: regulates GO:0043534 ! blood vessel endothelial cell migration

[Term]
id: GO:0043536
name: positive regulation of blood vessel endothelial cell migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels." [GOC:go_curators]
synonym: "activation of blood vessel endothelial cell migration" NARROW []
synonym: "stimulation of blood vessel endothelial cell migration" NARROW []
synonym: "up regulation of blood vessel endothelial cell migration" EXACT []
synonym: "up-regulation of blood vessel endothelial cell migration" EXACT []
synonym: "upregulation of blood vessel endothelial cell migration" EXACT []
is_a: GO:0010595 ! positive regulation of endothelial cell migration
is_a: GO:0043535 ! regulation of blood vessel endothelial cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043534 ! blood vessel endothelial cell migration
relationship: positively_regulates GO:0043534 ! blood vessel endothelial cell migration

[Term]
id: GO:0043537
name: negative regulation of blood vessel endothelial cell migration
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the migration of the endothelial cells of blood vessels." [GOC:go_curators]
synonym: "down regulation of blood vessel endothelial cell migration" EXACT []
synonym: "down-regulation of blood vessel endothelial cell migration" EXACT []
synonym: "downregulation of blood vessel endothelial cell migration" EXACT []
synonym: "inhibition of blood vessel endothelial cell migration" NARROW []
is_a: GO:0010596 ! negative regulation of endothelial cell migration
is_a: GO:0043535 ! regulation of blood vessel endothelial cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043534 ! blood vessel endothelial cell migration
relationship: negatively_regulates GO:0043534 ! blood vessel endothelial cell migration

[Term]
id: GO:0043538
name: regulation of actin phosphorylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the transfer of one or more phosphate groups to an actin molecule." [GOC:go_curators]
is_a: GO:0001932 ! regulation of protein phosphorylation
is_a: GO:0032956 ! regulation of actin cytoskeleton organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031289 ! actin phosphorylation
relationship: regulates GO:0031289 ! actin phosphorylation

[Term]
id: GO:0043539
name: protein serine/threonine kinase activator activity
namespace: molecular_function
def: "Binds to and increases the activity of a protein serine/threonine kinase." [GOC:go_curators]
synonym: "protein ser/thr kinase activator activity" EXACT []
is_a: GO:0030295 ! protein kinase activator activity
relationship: part_of GO:0071902 ! positive regulation of protein serine/threonine kinase activity
relationship: positively_regulates GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0043540
name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex
namespace: cellular_component
def: "A homodimeric, bifunctional enzyme complex which catalyzes the synthesis and degradation of fructose 2,6-bisphosphate, and is required for both glycolysis and gluconeogenesis." [GOC:jl, GOC:so]
comment: Note that we use this single class to represent all 4 isoforms of this complex. We decided to do this because the isoforms do not differ in function, rather in expression and regulation. We may want to revisit this in future.
synonym: "6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex" NARROW []
synonym: "6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 complex" NARROW []
synonym: "6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 complex" NARROW []
synonym: "6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 complex" NARROW []
is_a: GO:0044445 ! cytosolic part
is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups

[Term]
id: GO:0043541
name: UDP-N-acetylglucosamine transferase complex
namespace: cellular_component
def: "A multienzyme, heterooligomeric complex involved in dolichyl-linked oligosaccharide synthesis. In yeast the complex is composed of Alg7p, which catalyzes the first step (GlcNAc1-PP-Dol from dolichol-phosphate and UDP-GlcNAc), and Alg13p plus Alg14p, the catalytic and anchoring subunits respectively, which together catalyze the second step (GlcNAc2-PP-dolichol from GlcNAc1-PP-Dol and UDP-GlcNAc) of dolichyl-linked oligosaccharide synthesis." [GOC:rn, PMID:19129246]
comment: See also the molecular function term 'N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity ; GO:0004577'.
is_a: GO:0044432 ! endoplasmic reticulum part
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane

[Term]
id: GO:0043542
name: endothelial cell migration
namespace: biological_process
def: "The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium." [GOC:go_curators]
is_a: GO:0010631 ! epithelial cell migration

[Term]
id: GO:0043543
name: protein acylation
namespace: biological_process
def: "The addition of an acyl group, any group or radical of the form RCO- where R is an organic group, to a protein amino acid." [GOC:jl]
subset: goslim_yeast
subset: gosubset_prok
synonym: "protein amino acid acylation" EXACT [GOC:bf]
is_a: GO:0006464 ! cellular protein modification process

[Term]
id: GO:0043544
name: lipoamide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with lipoamide, the functional form of lipoic acid in which the carboxyl group is attached to protein by an amide linkage to a lysine amino group." [GOC:go_curators]
is_a: GO:0033218 ! amide binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding
is_a: GO:1901681 ! sulfur compound binding

[Term]
id: GO:0043545
name: molybdopterin cofactor metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [ISSN:09498257]
subset: gosubset_prok
synonym: "Moco metabolic process" EXACT []
synonym: "Moco metabolism" EXACT []
synonym: "molybdopterin cofactor metabolism" EXACT []
is_a: GO:0006732 ! coenzyme metabolic process
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:0051189 ! prosthetic group metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process

[Term]
id: GO:0043546
name: molybdopterin cofactor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [ISSN:09498257]
synonym: "Moco binding" EXACT []
is_a: GO:0050662 ! coenzyme binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding

[Term]
id: GO:0043547
name: positive regulation of GTPase activity
namespace: biological_process
alt_id: GO:0032320
alt_id: GO:0032321
alt_id: GO:0032850
alt_id: GO:0032851
alt_id: GO:0032852
alt_id: GO:0032853
alt_id: GO:0032854
alt_id: GO:0032855
alt_id: GO:0043089
def: "Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]
synonym: "activation of GTPase activity" NARROW []
synonym: "positive regulation of ARF GTPase activity" NARROW []
synonym: "positive regulation of Cdc42 GTPase activity" NARROW []
synonym: "positive regulation of Rab GTPase activity" NARROW []
synonym: "positive regulation of Rac GTPase activity" NARROW []
synonym: "positive regulation of Ral GTPase activity" NARROW []
synonym: "positive regulation of Ran GTPase activity" NARROW []
synonym: "positive regulation of Rap GTPase activity" NARROW []
synonym: "positive regulation of Ras GTPase activity" NARROW []
synonym: "positive regulation of Rho GTPase activity" NARROW []
synonym: "stimulation of ARF GTPase activity" NARROW []
synonym: "stimulation of Cdc42 GTPase activity" NARROW []
synonym: "stimulation of GTPase activity" NARROW []
synonym: "stimulation of Rab GTPase activity" NARROW []
synonym: "stimulation of Rac GTPase activity" NARROW []
synonym: "stimulation of Ral GTPase activity" NARROW []
synonym: "stimulation of Ran GTPase activity" NARROW []
synonym: "stimulation of Rap GTPase activity" NARROW []
synonym: "stimulation of Ras GTPase activity" NARROW []
synonym: "stimulation of Rho GTPase activity" NARROW []
synonym: "up regulation of ARF GTPase activity" NARROW []
synonym: "up regulation of Cdc42 GTPase activity" NARROW []
synonym: "up regulation of GTPase activity" EXACT []
synonym: "up regulation of Rab GTPase activity" NARROW []
synonym: "up regulation of Rac GTPase activity" NARROW []
synonym: "up regulation of Ral GTPase activity" NARROW []
synonym: "up regulation of Ran GTPase activity" NARROW []
synonym: "up regulation of Rap GTPase activity" NARROW []
synonym: "up regulation of Ras GTPase activity" NARROW []
synonym: "up regulation of Rho GTPase activity" NARROW []
synonym: "up-regulation of ARF GTPase activity" NARROW []
synonym: "up-regulation of Cdc42 GTPase activity" NARROW []
synonym: "up-regulation of GTPase activity" EXACT []
synonym: "up-regulation of Rab GTPase activity" NARROW []
synonym: "up-regulation of Rac GTPase activity" NARROW []
synonym: "up-regulation of Ral GTPase activity" NARROW []
synonym: "up-regulation of Ran GTPase activity" NARROW []
synonym: "up-regulation of Rap GTPase activity" NARROW []
synonym: "up-regulation of Ras GTPase activity" NARROW []
synonym: "up-regulation of Rho GTPase activity" NARROW []
synonym: "upregulation of ARF GTPase activity" NARROW []
synonym: "upregulation of Cdc42 GTPase activity" NARROW []
synonym: "upregulation of GTPase activity" EXACT []
synonym: "upregulation of Rab GTPase activity" NARROW []
synonym: "upregulation of Rac GTPase activity" NARROW []
synonym: "upregulation of Ral GTPase activity" NARROW []
synonym: "upregulation of Ran GTPase activity" NARROW []
synonym: "upregulation of Rap GTPase activity" NARROW []
synonym: "upregulation of Ras GTPase activity" NARROW []
synonym: "upregulation of Rho GTPase activity" NARROW []
is_a: GO:0043087 ! regulation of GTPase activity
is_a: GO:0051345 ! positive regulation of hydrolase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003924 ! GTPase activity
relationship: positively_regulates GO:0003924 ! GTPase activity

[Term]
id: GO:0043548
name: phosphatidylinositol 3-kinase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring." [PMID:10209156, PMID:9255069]
synonym: "phosphoinositide 3-kinase binding" EXACT [GOC:curators]
synonym: "PI3K binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0043549
name: regulation of kinase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:bf]
subset: gosubset_prok
is_a: GO:0042325 ! regulation of phosphorylation
is_a: GO:0051338 ! regulation of transferase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016301 ! kinase activity
relationship: regulates GO:0016301 ! kinase activity

[Term]
id: GO:0043550
name: regulation of lipid kinase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid." [GOC:bf]
subset: gosubset_prok
is_a: GO:0019216 ! regulation of lipid metabolic process
is_a: GO:0043549 ! regulation of kinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001727 ! lipid kinase activity
relationship: regulates GO:0001727 ! lipid kinase activity

[Term]
id: GO:0043551
name: regulation of phosphatidylinositol 3-kinase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phosphatidylinositol 3-kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an inositol lipid at the 3' position of the inositol ring." [GOC:bf]
synonym: "regulation of phosphoinositide 3-kinase activity" EXACT [GOC:curators]
is_a: GO:0043550 ! regulation of lipid kinase activity
is_a: GO:1903725 ! regulation of phospholipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035004 ! phosphatidylinositol 3-kinase activity
relationship: regulates GO:0035004 ! phosphatidylinositol 3-kinase activity

[Term]
id: GO:0043552
name: positive regulation of phosphatidylinositol 3-kinase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase activity." [GOC:bf]
synonym: "activation of phosphatidylinositol 3-kinase activity" NARROW []
synonym: "positive regulation of phosphoinositide 3-kinase activity" EXACT [GOC:curators]
synonym: "stimulation of phosphatidylinositol 3-kinase activity" NARROW []
synonym: "up regulation of phosphatidylinositol 3-kinase activity" EXACT []
synonym: "up-regulation of phosphatidylinositol 3-kinase activity" EXACT []
synonym: "upregulation of phosphatidylinositol 3-kinase activity" EXACT []
is_a: GO:0043551 ! regulation of phosphatidylinositol 3-kinase activity
is_a: GO:0090218 ! positive regulation of lipid kinase activity
is_a: GO:1903727 ! positive regulation of phospholipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035004 ! phosphatidylinositol 3-kinase activity
relationship: positively_regulates GO:0035004 ! phosphatidylinositol 3-kinase activity

[Term]
id: GO:0043553
name: negative regulation of phosphatidylinositol 3-kinase activity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of phosphatidylinositol 3-kinase activity." [GOC:bf]
synonym: "down regulation of phosphatidylinositol 3-kinase activity" EXACT []
synonym: "down-regulation of phosphatidylinositol 3-kinase activity" EXACT []
synonym: "downregulation of phosphatidylinositol 3-kinase activity" EXACT []
synonym: "inhibition of phosphatidylinositol 3-kinase activity" NARROW []
synonym: "negative regulation of phosphoinositide 3-kinase activity" EXACT [GOC:curators]
synonym: "negative regulation of PI3K activity" EXACT [GOC:bf]
is_a: GO:0043551 ! regulation of phosphatidylinositol 3-kinase activity
is_a: GO:0090219 ! negative regulation of lipid kinase activity
is_a: GO:1903726 ! negative regulation of phospholipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035004 ! phosphatidylinositol 3-kinase activity
relationship: negatively_regulates GO:0035004 ! phosphatidylinositol 3-kinase activity

[Term]
id: GO:0043554
name: aerobic respiration, using arsenite as electron donor
namespace: biological_process
def: "The oxidation of arsenite to arsenate, using oxygen (O2) as the electron acceptor. Arsenite oxidase provides electrons to an electron carrier which transfers them to oxygen utilizing respiratory systems." [GOC:mlg]
is_a: GO:0009060 ! aerobic respiration
is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds

[Term]
id: GO:0043555
name: regulation of translation in response to stress
namespace: biological_process
def: "Modulation of the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:jl]
synonym: "translational stress response" EXACT []
is_a: GO:0006417 ! regulation of translation
is_a: GO:0033554 ! cellular response to stress

[Term]
id: GO:0043556
name: regulation of translation in response to oxidative stress
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl]
is_a: GO:0043555 ! regulation of translation in response to stress
relationship: part_of GO:0034599 ! cellular response to oxidative stress

[Term]
id: GO:0043557
name: regulation of translation in response to osmotic stress
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the frequency, rate or extent of translation as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:jl]
is_a: GO:0006970 ! response to osmotic stress
is_a: GO:0043555 ! regulation of translation in response to stress

[Term]
id: GO:0043558
name: regulation of translational initiation in response to stress
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of translation initiation, as a result of a stimulus indicating the organism is under stress." [GOC:jl]
synonym: "regulation of translation initiation in response to stress" EXACT [GOC:dph, GOC:hjd, GOC:tb]
is_a: GO:0006446 ! regulation of translational initiation
is_a: GO:0043555 ! regulation of translation in response to stress

[Term]
id: GO:0043559
name: insulin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with insulin, a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [ISBN:0198506732]
is_a: GO:0005515 ! protein binding
is_a: GO:0017046 ! peptide hormone binding

[Term]
id: GO:0043560
name: insulin receptor substrate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any of the insulin receptor substrate (IRS) proteins, adaptor proteins that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex." [PMID:12829233]
synonym: "insulin receptor substrate [protein] binding" EXACT []
synonym: "IRS [protein] binding" EXACT []
synonym: "IRS binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0043561
name: regulation of translational initiation in response to osmotic stress
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of translation initiation, as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:dph, GOC:jl, GOC:tb]
is_a: GO:0043557 ! regulation of translation in response to osmotic stress
is_a: GO:0043558 ! regulation of translational initiation in response to stress

[Term]
id: GO:0043562
name: cellular response to nitrogen levels
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of inorganic nitrogen." [GOC:jl]
subset: gosubset_prok
is_a: GO:0031669 ! cellular response to nutrient levels

[Term]
id: GO:0043563
name: odorant transporter activity
namespace: molecular_function
def: "Enables the directed movement of odorants, any substance capable of stimulating the sense of smell, into, out of or within a cell, or between cells." [GOC:jl]
subset: gosubset_prok
is_a: GO:0005215 ! transporter activity

[Term]
id: GO:0043564
name: Ku70:Ku80 complex
namespace: cellular_component
def: "Heterodimeric protein complex composed of a 70 kDa and a 80 kDa subunit, binds DNA through a channel formed by the heterodimer. Functions in DNA double stranded break repair, chromosome maintenance, transcription regulation, V(D)J recombination, and activation of DNA-PK." [PMID:12518983]
synonym: "Ku70:Ku80 heterodimer" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0043565
name: sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
subset: gosubset_prok
synonym: "sequence specific DNA binding" EXACT []
is_a: GO:0003677 ! DNA binding

[Term]
id: GO:0043566
name: structure-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with DNA of a specific structure or configuration e.g. triplex DNA binding or bent DNA binding." [GOC:jl]
subset: gosubset_prok
synonym: "structure specific DNA binding" EXACT []
is_a: GO:0003677 ! DNA binding

[Term]
id: GO:0043567
name: regulation of insulin-like growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of insulin-like growth factor receptor signaling." [GOC:bf]
synonym: "regulation of IGF receptor signaling pathway" EXACT []
synonym: "regulation of IGF receptor signalling pathway" EXACT []
synonym: "regulation of insulin-like growth factor receptor signalling pathway" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048009 ! insulin-like growth factor receptor signaling pathway
relationship: regulates GO:0048009 ! insulin-like growth factor receptor signaling pathway

[Term]
id: GO:0043568
name: positive regulation of insulin-like growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of insulin-like growth factor receptor signaling." [GOC:bf]
synonym: "activation of insulin-like growth factor receptor signaling pathway" NARROW []
synonym: "positive regulation of IGF receptor signaling pathway" EXACT []
synonym: "positive regulation of IGF receptor signalling pathway" EXACT []
synonym: "positive regulation of insulin-like growth factor receptor signalling pathway" EXACT []
synonym: "stimulation of insulin-like growth factor receptor signaling pathway" NARROW []
synonym: "up regulation of insulin-like growth factor receptor signaling pathway" EXACT []
synonym: "up-regulation of insulin-like growth factor receptor signaling pathway" EXACT []
synonym: "upregulation of insulin-like growth factor receptor signaling pathway" EXACT []
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0043567 ! regulation of insulin-like growth factor receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048009 ! insulin-like growth factor receptor signaling pathway
relationship: positively_regulates GO:0048009 ! insulin-like growth factor receptor signaling pathway

[Term]
id: GO:0043569
name: negative regulation of insulin-like growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of insulin-like growth factor receptor signaling." [GOC:bf]
synonym: "down regulation of insulin-like growth factor receptor signaling pathway" EXACT []
synonym: "down-regulation of insulin-like growth factor receptor signaling pathway" EXACT []
synonym: "downregulation of insulin-like growth factor receptor signaling pathway" EXACT []
synonym: "inhibition of insulin-like growth factor receptor signaling pathway" NARROW []
synonym: "negative regulation of IGF receptor signaling pathway" EXACT []
synonym: "negative regulation of IGF receptor signalling pathway" EXACT []
synonym: "negative regulation of insulin-like growth factor receptor signalling pathway" EXACT []
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0043567 ! regulation of insulin-like growth factor receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048009 ! insulin-like growth factor receptor signaling pathway
relationship: negatively_regulates GO:0048009 ! insulin-like growth factor receptor signaling pathway

[Term]
id: GO:0043570
name: maintenance of DNA repeat elements
namespace: biological_process
def: "Any process involved in sustaining the fidelity and copy number of DNA repeat elements." [GOC:jl]
is_a: GO:0006259 ! DNA metabolic process
is_a: GO:0044710 ! single-organism metabolic process
is_a: GO:0051276 ! chromosome organization
is_a: GO:1902589 ! single-organism organelle organization

[Term]
id: GO:0043571
name: maintenance of CRISPR repeat elements
namespace: biological_process
def: "Any process involved in sustaining CRISPR repeat clusters, including capture of new spacer elements, expansion or contraction of clusters, propagation of the leader sequence and repeat clusters within a genome, transfer of repeat clusters and CRISPR-associated (cas) genes to new genomes, transcription of the CRISPR repeat arrays into RNA and processing, and interaction of CRISPR/cas loci with the host genome. CRISPR (clustered regularly interspaced short palindromic repeat) elements are a family of sequence elements containing multiple direct repeats of 24-48 bp with weak dyad symmetry which are separated by regularly sized nonrepetitive spacer sequences." [PMID:16292354]
synonym: "CRISPR element metabolic process" RELATED []
synonym: "CRISPR element metabolism" RELATED []
synonym: "maintenance of clustered regularly interspaced short palindromic repeat elements" EXACT []
is_a: GO:0043570 ! maintenance of DNA repeat elements

[Term]
id: GO:0043572
name: plastid fission
namespace: biological_process
def: "The creation of two or more plastids by division of one plastid. A plastid is any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA." [GOC:jl]
is_a: GO:0048285 ! organelle fission

[Term]
id: GO:0043573
name: leucoplast fission
namespace: biological_process
def: "The creation of two or more leucoplasts by division of one leucoplast. A leucoplast is a colorless plastid involved in the synthesis of monoterpenes." [GOC:jl]
is_a: GO:0043572 ! plastid fission

[Term]
id: GO:0043574
name: peroxisomal transport
namespace: biological_process
def: "Transport of substances into, out of or within a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:jl]
is_a: GO:1902582 ! single-organism intracellular transport

[Term]
id: GO:0043575
name: detection of osmotic stimulus
namespace: biological_process
def: "The series of events in which a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell is received and converted into a molecular signal." [GOC:jl]
is_a: GO:0006970 ! response to osmotic stress
is_a: GO:0009582 ! detection of abiotic stimulus

[Term]
id: GO:0043576
name: regulation of respiratory gaseous exchange
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the process of gaseous exchange between an organism and its environment." [GOC:jl]
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007585 ! respiratory gaseous exchange
relationship: regulates GO:0007585 ! respiratory gaseous exchange

[Term]
id: GO:0043577
name: chemotropism
namespace: biological_process
def: "The movement of an organism, or part of an organism, in response to an external chemical gradient, usually toward or away from it." [GOC:jl, PMID:10087613]
xref: Wikipedia:Chemotropism
is_a: GO:0009606 ! tropism
intersection_of: GO:0009606 ! tropism
intersection_of: part_of GO:0042221 ! response to chemical
relationship: part_of GO:0042221 ! response to chemical

[Term]
id: GO:0043578
name: nuclear matrix organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear matrix, the dense fibrillar network lying on the inner side of the nuclear membrane." [GOC:dph, GOC:jl, GOC:mah]
synonym: "nuclear matrix organisation" EXACT [GOC:curators]
synonym: "nuclear matrix organization and biogenesis" RELATED [GOC:mah]
synonym: "nucleoskeleton organization" EXACT [GOC:tb]
is_a: GO:0006997 ! nucleus organization

[Term]
id: GO:0043579
name: elaioplast organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an elaioplast, a leucoplast in which oil is stored." [GOC:jl]
synonym: "elaioplast organisation" EXACT [GOC:curators]
synonym: "elaioplast organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0009657 ! plastid organization

[Term]
id: GO:0043580
name: periplasmic space organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the periplasmic space, the region between the inner (cytoplasmic) and outer membrane in Gram-negative bacteria, or the inner membrane and cell wall in fungi." [GOC:dph, GOC:jl, GOC:mah]
subset: gosubset_prok
synonym: "periplasmic space organisation" EXACT [GOC:mah]
synonym: "periplasmic space organization and biogenesis" EXACT [GOC:dph, GOC:jl, GOC:mah]
is_a: GO:0016043 ! cellular component organization
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0043581
name: mycelium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the mycelium over time, from its formation to the mature structure. A mycelium consists of a mass of branching, thread-like hyphae." [GOC:jl, ISBN:1580085792, PMID:12832397]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007275 ! multicellular organism development

[Term]
id: GO:0043582
name: sporangium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the sporangium over time, from its formation to the mature structure. A sporangium is a structure producing and containing spores." [GOC:jl, Wikipedia:Sporagium]
synonym: "sporangia development" EXACT []
is_a: GO:0075259 ! spore-bearing organ development
is_a: GO:0099402 ! plant organ development

[Term]
id: GO:0043583
name: ear development
namespace: biological_process
def: "The process whose specific outcome is the progression of the ear over time, from its formation to the mature structure. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals." [GOC:jl, ISBN:0192801023]
synonym: "hearing organ development" EXACT []
is_a: GO:0007423 ! sensory organ development

[Term]
id: GO:0043584
name: nose development
namespace: biological_process
def: "The process whose specific outcome is the progression of the nose over time, from its formation to the mature structure. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity)." [GOC:jl, http://www.mercksource.com/]
synonym: "nasus development" EXACT []
is_a: GO:0007423 ! sensory organ development
relationship: part_of GO:0060541 ! respiratory system development

[Term]
id: GO:0043585
name: nose morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the nose are generated and organized. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity)." [GOC:jl, http://www.mercksource.com/]
synonym: "nasus morphogenesis" EXACT []
is_a: GO:0090596 ! sensory organ morphogenesis
relationship: part_of GO:0043584 ! nose development

[Term]
id: GO:0043586
name: tongue development
namespace: biological_process
def: "The process whose specific outcome is the progression of the tongue over time, from its formation to the mature structure. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in many other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech." [GOC:jl, UBERON:0001723]
synonym: "glossa development" NARROW []
synonym: "lingua development" NARROW []
is_a: GO:0007423 ! sensory organ development

[Term]
id: GO:0043587
name: tongue morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the tongue are generated and organized. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in man other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech." [GOC:jl, UBERON:0001723]
synonym: "glossa morphogenesis" NARROW []
synonym: "lingua morphogenesis" EXACT []
is_a: GO:0090596 ! sensory organ morphogenesis
relationship: part_of GO:0043586 ! tongue development

[Term]
id: GO:0043588
name: skin development
namespace: biological_process
def: "The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue." [GOC:jl, UBERON:0002097]
synonym: "animal skin development" EXACT []
is_a: GO:0048513 ! animal organ development

[Term]
id: GO:0043589
name: skin morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the skin are generated and organized. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner, sensitive and vascular dermis (cutis, corium or true skin) composed mostly of connective tissue." [GOC:jl, UBERON:0002097]
is_a: GO:0009887 ! organ morphogenesis
relationship: part_of GO:0043588 ! skin development

[Term]
id: GO:0043590
name: bacterial nucleoid
namespace: cellular_component
def: "The region of a bacterial cell to which the DNA is confined." [GOC:jl]
subset: gosubset_prok
is_a: GO:0009295 ! nucleoid
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle

[Term]
id: GO:0043591
name: endospore external encapsulating structure
namespace: cellular_component
alt_id: GO:0055030
def: "The structures that lie outside the inner membrane and surround the entire endospore; consists of a peptidoglycan-containing inner layer (the endospore cortex) surrounded by a multilayered proteinaceous coat. An exosporium may be present as an extreme outer layer." [GOC:go_curators, PMID:15035041]
subset: goslim_pir
synonym: "endospore wall" EXACT [GOC:mah]
synonym: "peptidoglycan-based spore wall" EXACT [GOC:mtg_sensu]
synonym: "spore wall" BROAD [GOC:mtg_sensu]
is_a: GO:0031160 ! spore wall

[Term]
id: GO:0043592
name: exosporium
namespace: cellular_component
def: "The outermost layer of a bacterial endospore, which is loosely attached and located outside of the endospore coat. It is generally composed of protein, carbohydrate, and perhaps lipid." [GOC:mlg]
subset: gosubset_prok
synonym: "epispore" RELATED []
synonym: "exospore" RELATED []
synonym: "perispore" RELATED []
is_a: GO:0044426 ! cell wall part
relationship: part_of GO:0043591 ! endospore external encapsulating structure

[Term]
id: GO:0043593
name: endospore coat
namespace: cellular_component
def: "The layer in a bacterial endospore that lies under the exosporium, and is impermeable to many toxic molecules. The coat may also contain enzymes that are involved in endospore germination." [GOC:mlg]
subset: gosubset_prok
is_a: GO:0044426 ! cell wall part
relationship: part_of GO:0043591 ! endospore external encapsulating structure

[Term]
id: GO:0043594
name: outer endospore membrane
namespace: cellular_component
def: "The outer membrane around a bacterial endospore, located between the endospore cortex and endospore coat." [GOC:mlg]
subset: gosubset_prok
is_a: GO:0019867 ! outer membrane
is_a: GO:0044426 ! cell wall part
intersection_of: GO:0019867 ! outer membrane
intersection_of: part_of GO:0043591 ! endospore external encapsulating structure
relationship: part_of GO:0043591 ! endospore external encapsulating structure

[Term]
id: GO:0043595
name: endospore cortex
namespace: cellular_component
def: "A layer surrounding a bacterial endospore found inside the outer endospore membrane, but outside the membrane surrounding the endospore core. It consists of peptidoglycan of a different chemical nature than that found in vegetative cell walls which results in less cross-linking of peptidoglycan." [GOC:mlg]
subset: gosubset_prok
is_a: GO:0044426 ! cell wall part
relationship: part_of GO:0043591 ! endospore external encapsulating structure

[Term]
id: GO:0043596
name: nuclear replication fork
namespace: cellular_component
def: "The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:jl, GOC:mtg_sensu]
is_a: GO:0005657 ! replication fork
is_a: GO:0044454 ! nuclear chromosome part
intersection_of: GO:0005657 ! replication fork
intersection_of: part_of GO:0005634 ! nucleus
relationship: has_part GO:0071162 ! CMG complex
relationship: part_of GO:0005634 ! nucleus

[Term]
id: GO:0043597
name: cytoplasmic replication fork
namespace: cellular_component
def: "The Y-shaped region of a cytoplasmic replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:jl, GOC:mtg_sensu]
is_a: GO:0005657 ! replication fork
is_a: GO:0044444 ! cytoplasmic part
intersection_of: GO:0005657 ! replication fork
intersection_of: part_of GO:0005737 ! cytoplasm
relationship: part_of GO:0000229 ! cytoplasmic chromosome
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0043598
name: cytoplasmic DNA replication factor C complex
namespace: cellular_component
def: "A cytoplasmic complex of two polypeptides that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. Examples of this component are found in prokaryotic species." [GOC:mtg_sensu, PMID:14646196, PMID:16172520]
synonym: "cytoplasmic clamp loader" EXACT []
synonym: "cytoplasmic RFC" EXACT []
is_a: GO:0005663 ! DNA replication factor C complex
is_a: GO:0044444 ! cytoplasmic part
intersection_of: GO:0005663 ! DNA replication factor C complex
intersection_of: part_of GO:0005737 ! cytoplasm
relationship: part_of GO:0005737 ! cytoplasm
relationship: part_of GO:0043600 ! cytoplasmic replisome

[Term]
id: GO:0043599
name: nuclear DNA replication factor C complex
namespace: cellular_component
def: "A nuclear complex of five polypeptides that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase delta or epsilon. In Saccharomyces and several other species, the subunits are known as Rfc1p-Rfc5p, although subunit names do not necessarily correspond between different species." [GOC:mtg_sensu, PMID:14614842]
synonym: "nuclear RFC" EXACT []
is_a: GO:0005663 ! DNA replication factor C complex
is_a: GO:0044454 ! nuclear chromosome part
intersection_of: GO:0005663 ! DNA replication factor C complex
intersection_of: part_of GO:0005634 ! nucleus
relationship: part_of GO:0005634 ! nucleus
relationship: part_of GO:0043601 ! nuclear replisome

[Term]
id: GO:0043600
name: cytoplasmic replisome
namespace: cellular_component
def: "A multi-component enzymatic machine at the cytoplasmic replication fork, which mediates DNA replication. Includes DNA primase, DNA polymerase, DNA helicase, and other proteins." [GOC:jl, GOC:mtg_sensu]
synonym: "prokaryotic replisome" EXACT []
is_a: GO:0030894 ! replisome
is_a: GO:0044444 ! cytoplasmic part
intersection_of: GO:0030894 ! replisome
intersection_of: part_of GO:0005737 ! cytoplasm
relationship: has_part GO:0009360 ! DNA polymerase III complex
relationship: has_part GO:0044777 ! single-stranded DNA-binding protein complex
relationship: part_of GO:0005737 ! cytoplasm
relationship: part_of GO:0043597 ! cytoplasmic replication fork

[Term]
id: GO:0043601
name: nuclear replisome
namespace: cellular_component
def: "A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins." [GOC:jl, GOC:mtg_sensu]
is_a: GO:0030894 ! replisome
is_a: GO:0044454 ! nuclear chromosome part
intersection_of: GO:0030894 ! replisome
intersection_of: part_of GO:0005634 ! nucleus
relationship: part_of GO:0005634 ! nucleus
relationship: part_of GO:0043596 ! nuclear replication fork

[Term]
id: GO:0043602
name: nitrate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of nitrates, inorganic or organic salts and esters of nitric acid." [GOC:jl]
synonym: "nitrate disassimilation" EXACT []
synonym: "nitrate dissimilation" EXACT []
is_a: GO:0042126 ! nitrate metabolic process
is_a: GO:0044270 ! cellular nitrogen compound catabolic process
is_a: GO:0044712 ! single-organism catabolic process

[Term]
id: GO:0043603
name: cellular amide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells." [CHEBI:32988]
subset: goslim_pir
subset: gosubset_prok
synonym: "amide metabolism" EXACT []
is_a: GO:0034641 ! cellular nitrogen compound metabolic process

[Term]
id: GO:0043604
name: amide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [CHEBI:32988]
is_a: GO:0043603 ! cellular amide metabolic process
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process

[Term]
id: GO:0043605
name: cellular amide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [CHEBI:32988]
is_a: GO:0043603 ! cellular amide metabolic process
is_a: GO:0044270 ! cellular nitrogen compound catabolic process

[Term]
id: GO:0043606
name: formamide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving formamide, the simplest amide, HCONH2, derived from formic acid." [GOC:jl, http://www.mercksource.com/]
synonym: "formamide metabolism" EXACT []
is_a: GO:0043603 ! cellular amide metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process

[Term]
id: GO:0043607
name: formamide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of formamide, the simplest amide, HCONH2, derived from formic acid." [GOC:jl, http://www.mercksource.com/]
is_a: GO:0043604 ! amide biosynthetic process
is_a: GO:0043606 ! formamide metabolic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process

[Term]
id: GO:0043608
name: formamide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of formamide, the simplest amide, HCONH2, derived from formic acid." [GOC:jl, http://www.mercksource.com/]
is_a: GO:0043605 ! cellular amide catabolic process
is_a: GO:0043606 ! formamide metabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process

[Term]
id: GO:0043609
name: regulation of carbon utilization
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of carbon utilization." [GOC:jl]
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0015976 ! carbon utilization
relationship: regulates GO:0015976 ! carbon utilization

[Term]
id: GO:0043610
name: regulation of carbohydrate utilization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of carbohydrate utilization." [GOC:jl]
synonym: "regulation of sugar utilization" NARROW [GOC:mcc2]
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009758 ! carbohydrate utilization
relationship: regulates GO:0009758 ! carbohydrate utilization

[Term]
id: GO:0043611
name: isoprene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving isoprene, C5H8." [GOC:jl]
subset: gosubset_prok
synonym: "2-methyl-1,3-butadiene metabolic process" EXACT []
synonym: "2-methyl-1,3-butadiene metabolism" EXACT []
synonym: "hemiterpene metabolic process" EXACT []
synonym: "hemiterpene metabolism" EXACT []
synonym: "isoprene metabolism" EXACT []
is_a: GO:0042214 ! terpene metabolic process
is_a: GO:1900673 ! olefin metabolic process

[Term]
id: GO:0043612
name: isoprene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of isoprene, C5H8." [GOC:jl]
synonym: "2-methyl-1,3-butadiene biosynthesis" EXACT []
synonym: "2-methyl-1,3-butadiene biosynthetic process" EXACT []
synonym: "hemiterpene biosynthesis" EXACT []
synonym: "hemiterpene biosynthetic process" EXACT []
is_a: GO:0043611 ! isoprene metabolic process
is_a: GO:0046246 ! terpene biosynthetic process
is_a: GO:1900674 ! olefin biosynthetic process

[Term]
id: GO:0043613
name: isoprene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of isoprene, C5H8." [GOC:jl]
synonym: "2-methyl-1,3-butadiene catabolic process" EXACT []
synonym: "2-methyl-1,3-butadiene catabolism" EXACT []
synonym: "hemiterpene catabolic process" EXACT []
synonym: "hemiterpene catabolism" EXACT []
is_a: GO:0043611 ! isoprene metabolic process
is_a: GO:0046247 ! terpene catabolic process

[Term]
id: GO:0043614
name: multi-eIF complex
namespace: cellular_component
def: "A multifactor complex composed of multiple translation initiation factors and the initiatior tRNAiMet, which is ready to bind to the small (40S) ribosome to form the 43S preinitiation complex. In S. cerevisiae, this complex is composed of eIF1, eIF2, eIF3, and eIF5." [GOC:krc]
synonym: "multifactor translation initiation factor (eIF) complex" EXACT []
is_a: GO:0030529 ! intracellular ribonucleoprotein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0043615
name: astrocyte cell migration
namespace: biological_process
def: "The orderly movement of an astrocyte, a class of large neuroglial (macroglial) cells in the central nervous system, the largest and most numerous neuroglial cells in the brain and spinal cord." [CL:0000127, GOC:go_curators]
synonym: "astrocyte migration" EXACT []
synonym: "astrocytic glial cell migration" EXACT []
is_a: GO:0008347 ! glial cell migration

[Term]
id: GO:0043616
name: keratinocyte proliferation
namespace: biological_process
def: "The multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. Keratinocytes are epidermal cells which synthesize keratin and undergo a characteristic change as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin." [CL:0000311]
is_a: GO:0050673 ! epithelial cell proliferation

[Term]
id: GO:0043617
name: cellular response to sucrose starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of sucrose." [GOC:jl]
is_a: GO:0009267 ! cellular response to starvation

[Term]
id: GO:0043618
name: regulation of transcription from RNA polymerase II promoter in response to stress
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:jl]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0043620 ! regulation of DNA-templated transcription in response to stress

[Term]
id: GO:0043619
name: regulation of transcription from RNA polymerase II promoter in response to oxidative stress
namespace: biological_process
def: "Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl]
is_a: GO:0043618 ! regulation of transcription from RNA polymerase II promoter in response to stress
relationship: part_of GO:0034599 ! cellular response to oxidative stress

[Term]
id: GO:0043620
name: regulation of DNA-templated transcription in response to stress
namespace: biological_process
def: "Modulation of the frequency, rate or extent of transcription from a DNA template as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:jl, GOC:txnOH]
synonym: "regulation of DNA-dependent transcription in response to stress" EXACT [GOC:txnOH]
is_a: GO:0006355 ! regulation of transcription, DNA-templated
is_a: GO:0033554 ! cellular response to stress

[Term]
id: GO:0043621
name: protein self-association
namespace: molecular_function
def: "Interacting selectively and non-covalently with a domain within the same polypeptide." [GOC:jl]
subset: goslim_chembl
synonym: "intramolecular protein binding" EXACT []
synonym: "protein self association" EXACT []
synonym: "protein self binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0043622
name: cortical microtubule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cell cortex, i.e. just beneath the plasma membrane of a cell." [GOC:curators, GOC:dph, GOC:jl, GOC:mah]
synonym: "cortical microtubule cytoskeleton organization" EXACT []
synonym: "cortical microtubule organisation" EXACT [GOC:curators]
synonym: "cortical microtubule organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0030865 ! cortical cytoskeleton organization
is_a: GO:0031122 ! cytoplasmic microtubule organization

[Term]
id: GO:0043623
name: cellular protein complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a protein complex, occurring at the level of an individual cell." [GOC:jl]
subset: gosubset_prok
is_a: GO:0006461 ! protein complex assembly
is_a: GO:0034622 ! cellular macromolecular complex assembly

[Term]
id: GO:0043624
name: cellular protein complex disassembly
namespace: biological_process
def: "The disaggregation of a protein complex into its constituent components, occurring at the level of an individual cell. Protein complexes may have other associated non-protein prosthetic groups, such as nucleic acids, metal ions or carbohydrate groups." [GOC:jl]
subset: gosubset_prok
is_a: GO:0043241 ! protein complex disassembly

[Term]
id: GO:0043625
name: delta DNA polymerase complex
namespace: cellular_component
alt_id: GO:0005659
def: "A multimeric DNA polymerase enzyme complex which differs in composition amongst species; in humans it is a heterotetramer of four subunits of approximately 125, 50, 68 and 12kDa, while in S. cerevisiae, it has three different subunits which form a heterotrimer, and the active enzyme is a dimer of this heterotrimer. Functions in DNA replication, mismatch repair and excision repair." [GOC:jl, ISBN:0198547684, PMID:11205330, PMID:12403614]
synonym: "delta-DNA polymerase complex" EXACT []
is_a: GO:0042575 ! DNA polymerase complex
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0043601 ! nuclear replisome

[Term]
id: GO:0043626
name: PCNA complex
namespace: cellular_component
def: "A protein complex composed of three identical PCNA monomers, each comprising two similar domains, which are joined in a head-to-tail arrangement to form a homotrimer. Forms a ring-like structure in solution, with a central hole sufficiently large to accommodate the double helix of DNA. Originally characterized as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the replisome, and has also been shown to be involved in other processes including Okazaki fragment processing, DNA repair, translesion DNA synthesis, DNA methylation, chromatin remodeling and cell cycle regulation." [GOC:jl, PMID:12829735]
subset: gosubset_prok
synonym: "PCNA homotrimer" EXACT []
synonym: "proliferating cell nuclear antigen complex" EXACT []
synonym: "sliding clamp" BROAD []
is_a: GO:0044796 ! DNA polymerase processivity factor complex

[Term]
id: GO:0043627
name: response to estrogen
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics." [GOC:jl, ISBN:0198506732]
synonym: "response to estrogen stimulus" EXACT [GOC:dos]
synonym: "response to oestrogen stimulus" EXACT []
is_a: GO:0048545 ! response to steroid hormone

[Term]
id: GO:0043628
name: ncRNA 3'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 3' end of a non-coding RNA molecule." [GOC:jl]
synonym: "ncRNA 3' end processing" EXACT []
is_a: GO:0031123 ! RNA 3'-end processing
is_a: GO:0034470 ! ncRNA processing

[Term]
id: GO:0043629
name: ncRNA polyadenylation
namespace: biological_process
def: "The enzymatic addition of a sequence of adenylyl residues at the 3' end of a non-coding RNA (ncRNA) molecule. In eukaryotes, substrates include nuclear non-coding RNAs such as precursors and a variety of incorrectly processed forms of snRNAs, snoRNAs, rRNAs, and tRNAs, as well as discarded RNA fragments which have been removed from ncRNA primary transcripts. Polyadenylation of precursors is often linked to termination of transcription, but polyadenylation of RNAs targeted for degradation may also occur post-transcriptionally. This polyadenylation is important both for 3'-end processing to produce mature ncRNA species and also for targeting incorrectly processed or discarded RNA molecules for degradation." [GOC:dgf, GOC:krc, GOC:rn, PMID:15828860, PMID:15935758, PMID:16374505, PMID:16431988, PMID:18951092]
synonym: "non-coding RNA polyadenylation" EXACT []
is_a: GO:0034660 ! ncRNA metabolic process
is_a: GO:0043631 ! RNA polyadenylation

[Term]
id: GO:0043630
name: ncRNA polyadenylation involved in polyadenylation-dependent ncRNA catabolic process
namespace: biological_process
def: "The enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end of a non-coding RNA, occurring as part of the process of polyadenylation-dependent non-coding RNA catabolism." [GOC:dph, GOC:jl, GOC:tb]
synonym: "ncRNA polyadenylation during polyadenylation-dependent ncRNA catabolic process" RELATED [GOC:dph, GOC:tb]
synonym: "ncRNA polyadenylation involved in poly(A)-dependent ncRNA catabolic process" RELATED [GOC:vw]
is_a: GO:0043629 ! ncRNA polyadenylation
relationship: part_of GO:0043634 ! polyadenylation-dependent ncRNA catabolic process

[Term]
id: GO:0043631
name: RNA polyadenylation
namespace: biological_process
def: "The enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule." [GOC:jl]
subset: gosubset_prok
is_a: GO:0016070 ! RNA metabolic process

[Term]
id: GO:0043632
name: modification-dependent macromolecule catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a macromolecule, initiated by covalent modification of the target molecule." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044265 ! cellular macromolecule catabolic process

[Term]
id: GO:0043633
name: polyadenylation-dependent RNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of an RNA molecule, initiated by initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3'-end of the target RNA." [GOC:dgf, GOC:jl, GOC:krc]
synonym: "polyadenylation-dependent RNA catabolic process" RELATED [GOC:vw]
is_a: GO:0006401 ! RNA catabolic process
is_a: GO:0043632 ! modification-dependent macromolecule catabolic process

[Term]
id: GO:0043634
name: polyadenylation-dependent ncRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a noncoding RNA (ncRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target ncRNA." [GOC:dgf, GOC:jl, GOC:krc]
synonym: "poly(A)-dependent ncRNA catabolic process" RELATED [GOC:vw]
is_a: GO:0034661 ! ncRNA catabolic process
is_a: GO:0043633 ! polyadenylation-dependent RNA catabolic process
relationship: has_part GO:0043629 ! ncRNA polyadenylation

[Term]
id: GO:0043635
name: methylnaphthalene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of methylnaphthalene, an organic compound, C10H7CH3, obtained from coal tar." [GOC:jl, PMID:16535687]
synonym: "1-methylnaphthalene catabolic process" NARROW []
synonym: "1-methylnaphthalene catabolism" NARROW []
synonym: "1-MN catabolic process" RELATED []
synonym: "1-MN catabolism" RELATED []
synonym: "2-methylnaphthalene catabolic process" NARROW []
synonym: "2-methylnaphthalene catabolism" NARROW []
synonym: "2-MN catabolic process" RELATED []
synonym: "2-MN catabolism" RELATED []
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0090420 ! naphthalene-containing compound metabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process

[Term]
id: GO:0043636
name: bisphenol A catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of bisphenol A, 4,4'-(propane-2,2-diyl)diphenol, a synthetic, aromatic organic compound used as a monomer in the manufacture of polycarbonate plastic and in the manufacture of epoxy resins." [CHEBI:33216, GOC:jl, Wikipedia:Bisphenol_A]
synonym: "bisphenol-A catabolic process" EXACT []
synonym: "bisphenol-A catabolism" EXACT []
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0042178 ! xenobiotic catabolic process

[Term]
id: GO:0043637
name: puromycin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving puromycin, 3'-deoxy-N,N-dimethyl-3'-(O-methyl-L-tyrosinamido)adenosine, an aminonucleoside antibiotic that is a potent inhibitor of translation; produced by the bacterium Streptomyces alboniger." [CHEBI:17939, GOC:jl, PMID:8226694, Wikipedia:Puromycin]
subset: gosubset_prok
synonym: "puromycin metabolism" EXACT []
is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0046128 ! purine ribonucleoside metabolic process

[Term]
id: GO:0043638
name: puromycin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of puromycin, an aminonucleoside antibiotic that is a potent inhibitor of translation; produced by the bacterium Streptomyces alboniger." [CHEBI:17939, GOC:jl, Wikipedia:Puromycin]
subset: gosubset_prok
is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0043637 ! puromycin metabolic process
is_a: GO:0046129 ! purine ribonucleoside biosynthetic process

[Term]
id: GO:0043639
name: benzoate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of benzoate, the anion of benzoic acid (benzenecarboxylic acid), a fungistatic compound widely used as a food preservative; it is conjugated to glycine in the liver and excreted as hippuric acid." [GOC:jl]
subset: gosubset_prok
synonym: "benzoate breakdown" EXACT []
synonym: "benzoate catabolism" EXACT []
synonym: "benzoate degradation" EXACT []
is_a: GO:0018874 ! benzoate metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process

[Term]
id: GO:0043640
name: benzoate catabolic process via hydroxylation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of benzoate, by its hydroxylation to cis-1,2-dihydroxybenzoate followed by dehydrogenation to catechol." [GOC:jl, MetaCyc:PWY-2503]
synonym: "benzoate breakdown via hydroxylation" EXACT []
synonym: "benzoate degradation via hydroxylation" EXACT []
xref: MetaCyc:PWY-2503
is_a: GO:0043639 ! benzoate catabolic process

[Term]
id: GO:0043641
name: novobiocin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving novobiocin, a coumarin antibiotic produced by the bacterium Gyrasestreptomyces spheroides, that acts by inhibiting DNA gyrase." [CHEBI:28368, GOC:jl]
subset: gosubset_prok
synonym: "novobiocin metabolism" EXACT []
xref: Wikipedia:Novobiocin
is_a: GO:0009804 ! coumarin metabolic process
is_a: GO:0016137 ! glycoside metabolic process
is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0043603 ! cellular amide metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process

[Term]
id: GO:0043642
name: novobiocin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of novobiocin, a coumarin antibiotic produced by the bacterium Gyrasestreptomyces spheroides, that acts by inhibiting DNA gyrase." [CHEBI:28368, GOC:jl]
subset: gosubset_prok
xref: Wikipedia:Novobiocin
is_a: GO:0009805 ! coumarin biosynthetic process
is_a: GO:0016138 ! glycoside biosynthetic process
is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process
is_a: GO:0043641 ! novobiocin metabolic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process

[Term]
id: GO:0043643
name: tetracycline metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tetracycline, (4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide, a broad-spectrum antibiotic produced by streptomyces bacteria that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles)." [CHEBI:27902, GOC:jl, Wikipedia:Tetracycline]
subset: gosubset_prok
synonym: "tetracyclin metabolic process" EXACT []
synonym: "tetracyclin metabolism" EXACT []
synonym: "tetracycline metabolism" EXACT []
is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0030638 ! polyketide metabolic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0043644
name: tetracycline biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tetracycline, (4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide, a broad-spectrum antibiotic produced by streptomyces bacteria that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles)." [CHEBI:27902, GOC:jl, Wikipedia:Tetracycline]
subset: gosubset_prok
synonym: "tetracyclin biosynthesis" EXACT []
synonym: "tetracyclin biosynthetic process" EXACT []
is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0030639 ! polyketide biosynthetic process
is_a: GO:0043643 ! tetracycline metabolic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process

[Term]
id: GO:0043645
name: cephalosporin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a cephalosporin, any of large class of tetracyclic triterpene broad-spectrum antibiotics similar both chemically and in their mode of action to penicillin, first isolated from the culture filtrates of mediterranean fungus acremonium (cephalosporium acremonium), and effective against gram-positive bacteria." [CHEBI:23066, GOC:jl, Wikipedia:Cephalosporin]
subset: gosubset_prok
synonym: "cephalosporin metabolism" EXACT []
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0030653 ! beta-lactam antibiotic metabolic process

[Term]
id: GO:0043646
name: cephalosporin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a cephalosporin, any of large class of tetracyclic triterpene broad-spectrum antibiotics similar both chemically and in their mode of action to penicillin, first isolated from the culture filtrates of mediterranean fungus acremonium (cephalosporium acremonium), and effective against gram-positive bacteria." [CHEBI:23066, GOC:jl, Wikipedia:Cephalosporin]
subset: gosubset_prok
is_a: GO:0030654 ! beta-lactam antibiotic biosynthetic process
is_a: GO:0043645 ! cephalosporin metabolic process
is_a: GO:0044272 ! sulfur compound biosynthetic process

[Term]
id: GO:0043647
name: inositol phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [CHEBI:24848, GOC:jl]
synonym: "inositol phosphate metabolism" EXACT []
synonym: "myo-inositol phosphate metabolic process" NARROW []
synonym: "myo-inositol phosphate metabolism" NARROW []
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:0019751 ! polyol metabolic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0043648
name: dicarboxylic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732]
subset: gosubset_prok
synonym: "dicarboxylate metabolic process" EXACT []
synonym: "dicarboxylate metabolism" EXACT []
synonym: "dicarboxylic acid metabolism" EXACT []
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0043649
name: dicarboxylic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups." [ISBN:0198506732]
subset: gosubset_prok
synonym: "dicarboxylate catabolic process" EXACT []
synonym: "dicarboxylate catabolism" EXACT []
synonym: "dicarboxylic acid breakdown" EXACT []
synonym: "dicarboxylic acid catabolism" EXACT []
synonym: "dicarboxylic acid degradation" EXACT []
is_a: GO:0043648 ! dicarboxylic acid metabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process

[Term]
id: GO:0043650
name: dicarboxylic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups." [ISBN:0198506732]
subset: gosubset_prok
synonym: "dicarboxylate biosynthesis" EXACT []
synonym: "dicarboxylate biosynthetic process" EXACT []
synonym: "dicarboxylic acid anabolism" EXACT []
synonym: "dicarboxylic acid biosynthesis" EXACT []
synonym: "dicarboxylic acid formation" EXACT []
synonym: "dicarboxylic acid synthesis" EXACT []
is_a: GO:0043648 ! dicarboxylic acid metabolic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process

[Term]
id: GO:0043651
name: linoleic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving linoleic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2." [Wikipedia:Linoleic_Acid]
synonym: "linoleic acid metabolism" EXACT []
xref: Wikipedia:Linoleic_acid
is_a: GO:0001676 ! long-chain fatty acid metabolic process
is_a: GO:0033559 ! unsaturated fatty acid metabolic process

[Term]
id: GO:0043652
name: engulfment of apoptotic cell
namespace: biological_process
def: "The removal of the apoptotic cell by phagocytosis, by a neighboring cell or by a phagocyte." [GOC:rk, PMID:15536015]
comment: This term should be used to annotate gene products from the engulfing cell that facilitate phagocytosis of apoptotic cells. It should not be mistaken with GO:0070782 'phosphatidylserine exposure on apoptotic cell surface', a process occurring in apoptotic cells that acts as a signal for engulfing cells. If gene products involved in such instances of phosphatidylserine exposure are shown to have a positive effect on engulfment, they may be annotated to GO:1901076 'positive regulation of engulfment of apoptotic cell'.
synonym: "engulfment of apoptotic cell corpse" EXACT []
synonym: "engulfment of cell corpse" EXACT []
is_a: GO:0006911 ! phagocytosis, engulfment
relationship: part_of GO:0043277 ! apoptotic cell clearance

[Term]
id: GO:0043653
name: mitochondrial fragmentation involved in apoptotic process
namespace: biological_process
def: "The change in the morphology of the mitochondria in an apoptotic cell from a highly branched network to a fragmented vesicular form." [GOC:mtg_apoptosis, GOC:rk, PMID:12867994]
comment: Although most of the processes described under 'apoptotic mitochondrial changes' take place during the signaling phase of apoptosis, 'mitochondrial fragmentation involved in apoptotic process' cannot be confidently placed there. It is still controversial whether this process is involved in the signaling phase of apoptosis or not, so it was placed under the more generic 'apoptotic mitochondrial changes' parent rather than linked to the signaling or the execution phase until further research clarifies the matter.
synonym: "mitochondrial fission during apoptosis" RELATED [GOC:dph, GOC:tb]
synonym: "mitochondrial fragmentation involved in apoptosis" NARROW []
is_a: GO:0008637 ! apoptotic mitochondrial changes

[Term]
id: GO:0043654
name: recognition of apoptotic cell
namespace: biological_process
def: "The process in which a cell interprets signals (in the form of specific proteins and lipids) on the surface of a dying cell which it will engulf and remove by phagocytosis." [GOC:rk, PMID:15536015]
synonym: "detection of apoptotic cell" EXACT []
synonym: "detection of apoptotic cell corpse" EXACT []
synonym: "detection of cell corpse" EXACT []
synonym: "recognition of apoptotic cell corpse" EXACT []
synonym: "recognition of cell corpse" EXACT []
is_a: GO:0006910 ! phagocytosis, recognition
relationship: part_of GO:0043277 ! apoptotic cell clearance

[Term]
id: GO:0043655
name: extracellular space of host
namespace: cellular_component
def: "The space within a host but external to the plasma membrane of host cells, e.g. within host bloodstream." [GOC:cc]
subset: gosubset_prok
synonym: "host extracellular space" EXACT []
is_a: GO:0044217 ! other organism part
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0018995 ! host

[Term]
id: GO:0043656
name: intracellular region of host
namespace: cellular_component
def: "That space within the plasma membrane of a host cell." [GOC:cc]
subset: gosubset_prok
synonym: "host intracellular" EXACT []
is_a: GO:0033643 ! host cell part

[Term]
id: GO:0043657
name: host cell
namespace: cellular_component
def: "A cell within a host organism. Includes the host plasma membrane and any external encapsulating structures such as the host cell wall and cell envelope." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044216 ! other organism cell
relationship: part_of GO:0018995 ! host

[Term]
id: GO:0043658
name: host symbiosome
namespace: cellular_component
def: "A double-enveloped cell compartment, composed of the endosymbiont with its plasmalemma (as inner envelope) and an outer envelope (the perisymbiontic membrane) derived from the host cell." [GOC:cc]
subset: gosubset_prok
is_a: GO:0033648 ! host intracellular membrane-bounded organelle
is_a: GO:0033655 ! host cell cytoplasm part

[Term]
id: GO:0043659
name: symbiosome
namespace: cellular_component
def: "A double-enveloped cell compartment, composed of an endosymbiont with its plasmalemma (as inner envelope) and a non-endosymbiotic outer envelope (the perisymbiontic membrane)." [GOC:cc]
subset: gosubset_prok
is_a: GO:0030139 ! endocytic vesicle

[Term]
id: GO:0043660
name: bacteroid-containing symbiosome
namespace: cellular_component
def: "A symbiosome containing any of various structurally modified bacteria, such as those occurring on the root nodules of leguminous plants." [GOC:cc]
subset: gosubset_prok
is_a: GO:0043659 ! symbiosome

[Term]
id: GO:0043661
name: peribacteroid membrane
namespace: cellular_component
def: "A membrane that surrounds one or more bacteroids (such as nitrogen-fixing bacteroids within legume root nodule cells)." [GOC:cc]
subset: gosubset_prok
is_a: GO:0030666 ! endocytic vesicle membrane
relationship: part_of GO:0043660 ! bacteroid-containing symbiosome

[Term]
id: GO:0043662
name: peribacteroid fluid
namespace: cellular_component
def: "The soluble material inside the peribacteroid membrane, but outside of the bacteroid, within a bacteroid-containing symbiosome." [GOC:cc]
subset: gosubset_prok
is_a: GO:0044433 ! cytoplasmic vesicle part
relationship: part_of GO:0043660 ! bacteroid-containing symbiosome

[Term]
id: GO:0043663
name: host bacteroid-containing symbiosome
namespace: cellular_component
def: "A symbiosome containing any of various structurally modified bacteria, such as those occurring on the root nodules of leguminous plants, of a host cell." [GOC:cc]
subset: gosubset_prok
is_a: GO:0043658 ! host symbiosome

[Term]
id: GO:0043664
name: host peribacteroid membrane
namespace: cellular_component
def: "A host-derived membrane that surrounds one or more bacteroids (such as nitrogen-fixing bacteroids within legume root nodule cells)." [GOC:cc]
subset: gosubset_prok
is_a: GO:0033643 ! host cell part
relationship: part_of GO:0043663 ! host bacteroid-containing symbiosome

[Term]
id: GO:0043665
name: host peribacteroid fluid
namespace: cellular_component
def: "The soluble material inside the peribacteroid membrane, but outside of the bacteroid, within a bacteroid-containing symbiosome of a host cell." [GOC:cc]
subset: gosubset_prok
is_a: GO:0033643 ! host cell part
relationship: part_of GO:0043663 ! host bacteroid-containing symbiosome

[Term]
id: GO:0043666
name: regulation of phosphoprotein phosphatase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phosphoprotein phosphatase activity, the catalysis of the hydrolysis of phosphate from a phosphoprotein." [GOC:jp, PMID:11724821]
is_a: GO:0010921 ! regulation of phosphatase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004721 ! phosphoprotein phosphatase activity
relationship: regulates GO:0004721 ! phosphoprotein phosphatase activity

[Term]
id: GO:0043667
name: pollen wall
namespace: cellular_component
def: "The complex wall surrounding a pollen grain." [GOC:fz]
comment: Note that this term is a child of 'extracellular matrix part ; GO:0044420' rather than the more specific middle lamella-containing extracellular matrix ; GO:0048196', because unlike the usual plant cell wall, the pollen wall does not contain a middle lamella, as specified in the definition of 'middle lamella-containing extracellular matrix ; GO:0048196'.
synonym: "microspore wall" EXACT []
is_a: GO:0044420 ! extracellular matrix component

[Term]
id: GO:0043668
name: exine
namespace: cellular_component
def: "The outer layer of the pollen grain wall which is composed primarily of sporopollenin." [http://www.mobot.org/MOBOT/research/APweb/]
comment: Note that the exine is highly resistant to strong acids and bases.
is_a: GO:0044420 ! extracellular matrix component
relationship: part_of GO:0043667 ! pollen wall

[Term]
id: GO:0043669
name: ectexine
namespace: cellular_component
def: "The outer part of the exine, which stains positively with basic fuchsin in optical microscopy and has higher electron density in conventionally prepared TEM sections." [http://www.mobot.org/MOBOT/research/APweb/]
comment: Note that ectexine is distinguished on staining properties; compare with 'sexine ; GO:0043673'. See also 'endexine ; GO:0043671'.
is_a: GO:0044420 ! extracellular matrix component
relationship: part_of GO:0043668 ! exine

[Term]
id: GO:0043670
name: foot layer
namespace: cellular_component
def: "The inner layer of the ectexine." [http://www.mobot.org/MOBOT/research/APweb/]
synonym: "nexine 1" EXACT []
is_a: GO:0044420 ! extracellular matrix component
relationship: part_of GO:0043669 ! ectexine

[Term]
id: GO:0043671
name: endexine
namespace: cellular_component
def: "The inner part of the exine, which stains." [http://www.mobot.org/MOBOT/research/APweb/]
comment: Note that endexine is distinguished on staining properties; compare with 'sexine ; GO:0043673'. See also 'ectexine ; GO:0043669'.
is_a: GO:0044420 ! extracellular matrix component
relationship: part_of GO:0043668 ! exine

[Term]
id: GO:0043672
name: nexine
namespace: cellular_component
def: "The inner, non-sculptured part of the exine which lies below the sexine." [http://www.mobot.org/MOBOT/research/APweb/]
comment: Note that nexine is distinguished on purely morphological criteria; compare with 'endexine ; GO:0043671'. See also 'sexine ; GO:0043673'.
is_a: GO:0044420 ! extracellular matrix component
relationship: part_of GO:0043668 ! exine

[Term]
id: GO:0043673
name: sexine
namespace: cellular_component
def: "The outer, sculptured layer of the exine, which lies above the nexine." [http://www.mobot.org/MOBOT/research/APweb/]
comment: Note that the sexine sometimes consists of 5 layers, but of those, 3 layers are the most common (sexine 1 = columellae; sexine 2 = tectum; sexine 3 = sculpture elements). Sexine is distinguished on purely morphological criteria; compare with 'ectexine ; GO:0043669'. See also 'nexine ; GO:0043672'.
is_a: GO:0044420 ! extracellular matrix component
relationship: part_of GO:0043668 ! exine

[Term]
id: GO:0043674
name: columella
namespace: cellular_component
def: "A rod-like element of the sexine and ectexine, supporting either the tectum (the layer of sexine which forms a roof over the columella), or supporting a caput (an architectural element on top of a columella)." [http://www.mobot.org/MOBOT/research/APweb/]
synonym: "sexine 1" EXACT []
is_a: GO:0044420 ! extracellular matrix component
relationship: part_of GO:0043673 ! sexine

[Term]
id: GO:0043675
name: sculpture element
namespace: cellular_component
def: "The third layer of the sexine." [http://www.mobot.org/MOBOT/research/APweb/]
is_a: GO:0044420 ! extracellular matrix component
relationship: part_of GO:0043673 ! sexine

[Term]
id: GO:0043676
name: tectum
namespace: cellular_component
def: "The layer of sexine which forms a roof over the columella, granules or other infratectal elements." [http://www.mobot.org/MOBOT/research/APweb/]
synonym: "sexine 2" EXACT []
is_a: GO:0044420 ! extracellular matrix component
relationship: part_of GO:0043673 ! sexine

[Term]
id: GO:0043677
name: germination pore
namespace: cellular_component
def: "A small pore in the outer wall of a mycelial spore through which the germ tube exits upon germination. It can be apical or eccentric in its location." [Wikipedia:Germ_pore]
synonym: "germ pore" EXACT []
xref: Wikipedia:Germ_pore
is_a: GO:0044420 ! extracellular matrix component

[Term]
id: GO:0043678
name: intine
namespace: cellular_component
def: "The innermost of the major layers of the pollen grain wall which underlies the exine and borders the cytoplasm." [http://www.mobot.org/MOBOT/research/APweb/]
comment: Note that the intine is not acetolysis resistant and is therefore absent in conventionally prepared palynological material.
is_a: GO:0044420 ! extracellular matrix component
relationship: part_of GO:0043667 ! pollen wall

[Term]
id: GO:0043679
name: axon terminus
namespace: cellular_component
def: "Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it." [GOC:dph, GOC:jl]
synonym: "axon terminal" EXACT [NIF_Subcellular:sao2007137787]
synonym: "axon terminal specialization" RELATED []
synonym: "motor endplate" RELATED [NIF_Subcellular:nlx_subcell_20090512]
synonym: "nerve ending" EXACT []
xref: NIF_Subcellular:nlx_subcell_20090512
is_a: GO:0033267 ! axon part
is_a: GO:0044306 ! neuron projection terminus

[Term]
id: GO:0043680
name: filiform apparatus
namespace: cellular_component
def: "A complex of cell wall invaginations in a synergid cell, similar to those in transfer cells." [ISBN:0471245208]
is_a: GO:0044426 ! cell wall part

[Term]
id: GO:0043682
name: copper-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+ = ADP + phosphate + Cu2+, directly driving the transport of the copper ions across a membrane." [GOC:jl]
subset: gosubset_prok
xref: Reactome:REACT_24963 "Copper sequestration by copper-transporting ATPase 2, Homo sapiens"
xref: RHEA:10379
is_a: GO:0005375 ! copper ion transmembrane transporter activity
is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
is_a: GO:0019829 ! cation-transporting ATPase activity

[Term]
id: GO:0043683
name: type IV pilus biogenesis
namespace: biological_process
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a type IV pilus. A type IV pilus is composed of a pilus fiber and approximately ten proteins at its base; type IV pili play a role in cell motility, adherence to substrates, and aggregation." [GOC:jl, GOC:ml]
synonym: "TFP biogenesis" EXACT []
synonym: "type 4 pilus biogenesis" EXACT []
synonym: "type IV fimbria assembly" EXACT []
synonym: "type IV fimbria biogenesis" EXACT []
synonym: "type IV fimbriae assembly" EXACT []
synonym: "type IV fimbriae biogenesis" EXACT []
synonym: "type IV fimbrial assembly" EXACT []
synonym: "type IV fimbrial biogenesis" EXACT []
synonym: "type IV fimbrium assembly" EXACT []
synonym: "type IV fimbrium biogenesis" EXACT []
synonym: "type IV pilus biosynthesis" EXACT []
is_a: GO:0009297 ! pilus assembly
is_a: GO:0044085 ! cellular component biogenesis

[Term]
id: GO:0043684
name: type IV secretion system complex
namespace: cellular_component
def: "A complex of proteins related to those involved in bacterial DNA conjugative transfer, that permits the transfer of DNA or proteins into the extracellular milieu or directly into host cells. In general the type IV complex forms a multisubunit cell-envelope-spanning structure composed of a secretion channel and often a pilus or other surface filament or protein(s)." [GOC:ml]
subset: gosubset_prok
synonym: "T4SS complex" EXACT []
synonym: "type IV protein secretion system complex" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0043685
name: conversion of glutamyl-tRNA to glutaminyl-tRNA
namespace: biological_process
def: "The modification process that results in the conversion of glutamate charged on a tRNA(Gln) to glutaminyl-tRNA." [GOC:jsg, PMID:3340166, PMID:9342308]
comment: Note that this process has been observed in some archaeal and bacterial species.
subset: gosubset_prok
is_a: GO:0019988 ! charged-tRNA amino acid modification

[Term]
id: GO:0043686
name: co-translational protein modification
namespace: biological_process
def: "The process of covalently altering one or more amino acids in a protein after translation has begun but before the protein has been released from the ribosome." [GOC:jsg]
comment: This term should only be used to annotate a protein modification process that occurs after the start of translation but while the protein is still on the ribosome.
synonym: "co-translational amino acid modification" EXACT []
synonym: "co-translational modification" EXACT []
synonym: "cotranslational amino acid modification" EXACT []
synonym: "cotranslational modification" EXACT []
synonym: "cotranslational protein modification" EXACT []
is_a: GO:0006464 ! cellular protein modification process

[Term]
id: GO:0043687
name: post-translational protein modification
namespace: biological_process
def: "The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome." [GOC:jsg]
comment: This term should only be used to annotate a protein modification process that occurs after the protein has been released from the ribosome, and is therefore strictly post-translational. Modification of a free protein (one not attached to a ribosome) and modification of a C-terminal residue are post-translational processes. Some protein modifications occur while the protein is still in the ribosome but before translation has been completed; these modification processes are considered co-translational and should not be annotated using this term.
subset: gosubset_prok
synonym: "post-translational amino acid modification" EXACT []
synonym: "post-translational modification" EXACT []
synonym: "posttranslational amino acid modification" EXACT []
synonym: "posttranslational modification" EXACT []
synonym: "posttranslational protein modification" EXACT []
synonym: "PTM" EXACT []
xref: Reactome:REACT_100887 "Post-translational protein modification, Canis familiaris"
xref: Reactome:REACT_101114 "Post-translational protein modification, Arabidopsis thaliana"
xref: Reactome:REACT_103281 "PTM: gamma carboxylation, hypusine formation and arylsulfatase activation, Saccharomyces cerevisiae"
xref: Reactome:REACT_103494 "PTM: gamma carboxylation, hypusine formation and arylsulfatase activation, Schizosaccharomyces pombe"
xref: Reactome:REACT_104966 "Post-translational protein modification, Saccharomyces cerevisiae"
xref: Reactome:REACT_105450 "PTM: gamma carboxylation, hypusine formation and arylsulfatase activation, Danio rerio"
xref: Reactome:REACT_1069 "PTM: gamma carboxylation, hypusine formation and arylsulfatase activation, Homo sapiens"
xref: Reactome:REACT_109761 "Post-translational protein modification, Gallus gallus"
xref: Reactome:REACT_113592 "PTM: gamma carboxylation, hypusine formation and arylsulfatase activation, Caenorhabditis elegans"
xref: Reactome:REACT_22161 "Post-translational protein modification, Homo sapiens"
xref: Reactome:REACT_29658 "PTM: gamma carboxylation, hypusine formation and arylsulfatase activation, Gallus gallus"
xref: Reactome:REACT_31587 "PTM: gamma carboxylation, hypusine formation and arylsulfatase activation, Drosophila melanogaster"
xref: Reactome:REACT_31741 "Post-translational protein modification, Dictyostelium discoideum"
xref: Reactome:REACT_33179 "Post-translational protein modification, Danio rerio"
xref: Reactome:REACT_33269 "Post-translational protein modification, Taeniopygia guttata"
xref: Reactome:REACT_33662 "PTM: gamma carboxylation, hypusine formation and arylsulfatase activation, Oryza sativa"
xref: Reactome:REACT_34647 "Post-translational protein modification, Xenopus tropicalis"
xref: Reactome:REACT_78360 "Post-translational protein modification, Sus scrofa"
xref: Reactome:REACT_78573 "Post-translational protein modification, Caenorhabditis elegans"
xref: Reactome:REACT_81500 "Post-translational protein modification, Schizosaccharomyces pombe"
xref: Reactome:REACT_81635 "PTM: gamma carboxylation, hypusine formation and arylsulfatase activation, Mus musculus"
xref: Reactome:REACT_82133 "Post-translational protein modification, Bos taurus"
xref: Reactome:REACT_82385 "PTM: gamma carboxylation, hypusine formation and arylsulfatase activation, Xenopus tropicalis"
xref: Reactome:REACT_83056 "Post-translational protein modification, Plasmodium falciparum"
xref: Reactome:REACT_83451 "PTM: gamma carboxylation, hypusine formation and arylsulfatase activation, Taeniopygia guttata"
xref: Reactome:REACT_83761 "Post-translational protein modification, Drosophila melanogaster"
xref: Reactome:REACT_85268 "PTM: gamma carboxylation, hypusine formation and arylsulfatase activation, Sus scrofa"
xref: Reactome:REACT_87023 "Post-translational protein modification, Mus musculus"
xref: Reactome:REACT_88089 "Post-translational protein modification, Rattus norvegicus"
xref: Reactome:REACT_88325 "PTM: gamma carboxylation, hypusine formation and arylsulfatase activation, Canis familiaris"
xref: Reactome:REACT_89018 "PTM: gamma carboxylation, hypusine formation and arylsulfatase activation, Rattus norvegicus"
xref: Reactome:REACT_91093 "PTM: gamma carboxylation, hypusine formation and arylsulfatase activation, Bos taurus"
xref: Reactome:REACT_91222 "Post-translational protein modification, Oryza sativa"
xref: Reactome:REACT_91597 "PTM: gamma carboxylation, hypusine formation and arylsulfatase activation, Arabidopsis thaliana"
xref: Reactome:REACT_96864 "PTM: gamma carboxylation, hypusine formation and arylsulfatase activation, Dictyostelium discoideum"
xref: Wikipedia:Posttranslational_modification
is_a: GO:0006464 ! cellular protein modification process

[Term]
id: GO:0043688
name: conversion of aspartyl-tRNA to asparaginyl-tRNA
namespace: biological_process
def: "The modification process that results in the conversion of aspartate charged on a tRNA(Asn) to asparaginyl-tRNA." [GOC:jsg, PMID:9789001]
comment: Note that this process has been observed in some archeal and bacterial species.
subset: gosubset_prok
is_a: GO:0019988 ! charged-tRNA amino acid modification

[Term]
id: GO:0043689
name: cell-cell adhesion involved in flocculation
namespace: biological_process
def: "The attachment of one single cell organism to another via adhesion molecules, occurring as a part of flocculation." [GOC:dos, GOC:jl]
subset: gosubset_prok
is_a: GO:0098741 ! adhesion between unicellular organisms via cell-wall interaction
intersection_of: GO:0098741 ! adhesion between unicellular organisms via cell-wall interaction
intersection_of: part_of GO:0000128 ! flocculation
relationship: part_of GO:0000128 ! flocculation

[Term]
id: GO:0043690
name: cell-cell adhesion involved in flocculation via cell wall protein-carbohydrate interaction
namespace: biological_process
def: "The attachment of one single cell organism to another during flocculation via the interaction a protein in the cell wall of one cell with a carbohydrate in the cell wall of another  In Saccharomyces this process is mannose-sensitive." [GOC:dos, GOC:jl]
subset: gosubset_prok
is_a: GO:0043689 ! cell-cell adhesion involved in flocculation
intersection_of: GO:0098610 ! adhesion between unicellular organisms
intersection_of: part_of GO:0000501 ! flocculation via cell wall protein-carbohydrate interaction
relationship: part_of GO:0000501 ! flocculation via cell wall protein-carbohydrate interaction

[Term]
id: GO:0043691
name: reverse cholesterol transport
namespace: biological_process
def: "The directed movement of peripheral cell cholesterol, cholest-5-en-3-beta-ol, towards the liver for catabolism." [GOC:ecd, PMID:7751809]
is_a: GO:0030301 ! cholesterol transport

[Term]
id: GO:0043692
name: monoterpene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving monoterpenes, terpenes with a C10 structure." [CHEBI:35187]
subset: gosubset_prok
synonym: "monoterpene metabolism" EXACT []
is_a: GO:0042214 ! terpene metabolic process

[Term]
id: GO:0043693
name: monoterpene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of monoterpenes, terpenes with a C10 structure." [CHEBI:35187]
subset: gosubset_prok
synonym: "monoterpene biosynthesis" EXACT []
is_a: GO:0043692 ! monoterpene metabolic process
is_a: GO:0046246 ! terpene biosynthetic process

[Term]
id: GO:0043694
name: monoterpene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of monoterpenes, terpenes with a C10 structure." [CHEBI:35187]
subset: gosubset_prok
synonym: "monoterpene catabolism" EXACT []
is_a: GO:0043692 ! monoterpene metabolic process
is_a: GO:0046247 ! terpene catabolic process

[Term]
id: GO:0043695
name: detection of pheromone
namespace: biological_process
def: "The series of events in which a pheromone stimulus is received by a cell and converted into a molecular signal." [GOC:mah]
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0019236 ! response to pheromone

[Term]
id: GO:0043696
name: dedifferentiation
namespace: biological_process
def: "The process in which a specialized structure (cell, tissue or organ) loses structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these structures can revert back to the features of their ancestors." [GOC:dph, GOC:pg]
xref: Wikipedia:Cellular_differentiation#Dedifferentiation
is_a: GO:0044767 ! single-organism developmental process

[Term]
id: GO:0043697
name: cell dedifferentiation
namespace: biological_process
def: "The process in which a specialized cell loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors." [GOC:dph, GOC:pg]
comment: Note that this term should be used to annotate gene products involved in dedifferentiation that occurs as part of a normal process, such as regeneration. It should not be used for dedifferentiation that occurs in an abnormal or disease state such as cancer.
is_a: GO:0043696 ! dedifferentiation
is_a: GO:0048869 ! cellular developmental process

[Term]
id: GO:0043698
name: iridosome
namespace: cellular_component
def: "A tissue-specific, membrane-bounded cytoplasmic organelle within which purines crystalize in reflective stacks. Iridosomes are synthesized in iridophore cells and are silver, gold or iridescent in appearance." [GOC:mh]
synonym: "reflecting platelet" EXACT []
is_a: GO:0048770 ! pigment granule

[Term]
id: GO:0043699
name: leucosome
namespace: cellular_component
def: "A tissue-specific, membrane-bounded cytoplasmic organelle within which uric acid and/or purines crystalize in reflective stacks. Leucosomes are synthesized in leucophore cells and have a whitish cast." [GOC:mh]
synonym: "refractosome" EXACT []
is_a: GO:0048770 ! pigment granule

[Term]
id: GO:0043700
name: pterinosome
namespace: cellular_component
def: "A tissue-specific, membrane-bounded cytoplasmic organelle within which pteridine pigments are synthesized and stored. Pterinosomes are synthesized in xanthophores and erythrophore cells and are yellow, orange or red in appearance." [GOC:mh]
is_a: GO:0048770 ! pigment granule

[Term]
id: GO:0043701
name: cyanosome
namespace: cellular_component
def: "A tissue-specific, membrane-bounded cytoplasmic organelle within which an unknown blue pigment is localized. Cyanosomes are synthesized in cyanophores and are blue in appearance." [GOC:mh]
is_a: GO:0048770 ! pigment granule

[Term]
id: GO:0043702
name: carotenoid vesicle
namespace: cellular_component
def: "A tissue-specific cytoplasmic vesicle surrounded by a membrane half-leaflet within which carotenoid pigments are stored. Carotenoid vesicles are synthesized in xanthophores and erythrophore cells and are yellow, orange or red in appearance." [GOC:mh]
is_a: GO:0031410 ! cytoplasmic vesicle

[Term]
id: GO:0043703
name: photoreceptor cell fate determination
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a photoreceptor cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:mtg_sensu]
is_a: GO:0048664 ! neuron fate determination
relationship: part_of GO:0046552 ! photoreceptor cell fate commitment

[Term]
id: GO:0043704
name: photoreceptor cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a photoreceptor cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:mtg_sensu]
is_a: GO:0048665 ! neuron fate specification
relationship: part_of GO:0046552 ! photoreceptor cell fate commitment

[Term]
id: GO:0043705
name: cyanophycin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cyanophycin, a non-protein, non-ribosomally produced amino acid polymer composed of an aspartic acid backbone and arginine side groups." [GOC:jl]
synonym: "cyanophycin metabolism" EXACT []
synonym: "multi-L-arginyl-poly(L-aspartic acid) metabolism" EXACT []
is_a: GO:0006518 ! peptide metabolic process
is_a: GO:0006575 ! cellular modified amino acid metabolic process
is_a: GO:0043170 ! macromolecule metabolic process

[Term]
id: GO:0043706
name: heterophilic cell adhesion involved in cytoadherence to microvasculature, mediated by parasite protein
namespace: biological_process
def: "The attachment of an erythrocyte to the microvasculature via a parasite cell adhesion molecule. This may be via attachment to host endothelial cell ECM or to endothelial cell adhesion molecules. An example of this occurs during infection with the malaria parasite." [GOC:jl, PMID:10362584, PMID:23376131]
is_a: GO:0098740 ! multi organism cell adhesion
relationship: part_of GO:0020035 ! cytoadherence to microvasculature, mediated by symbiont protein

[Term]
id: GO:0043707
name: cell adhesion involved in single-species biofilm formation in or on host organism
namespace: biological_process
def: "The attachment of a cell to either a host cell or a microbial cell of the same species, or to an underlying host substrate, such as the extracellular matrix, via cell adhesion molecules, occurring during the formation of a biofilm in or on a host species." [GOC:jl]
synonym: "cell adhesion during single-species biofilm formation in or on host organism" RELATED [GOC:dph]
is_a: GO:0043709 ! cell adhesion involved in single-species biofilm formation
intersection_of: GO:0007155 ! cell adhesion
intersection_of: part_of GO:0044407 ! single-species biofilm formation in or on host organism
relationship: part_of GO:0044407 ! single-species biofilm formation in or on host organism

[Term]
id: GO:0043708
name: cell adhesion involved in biofilm formation
namespace: biological_process
def: "The attachment of a cell to a solid substrate, via cell adhesion molecules, contributing to the formation of a biofilm." [GOC:dph, GOC:jl, GOC:tb]
synonym: "cell adhesion during biofilm formation" RELATED [GOC:dph, GOC:tb]
is_a: GO:0031589 ! cell-substrate adhesion
intersection_of: GO:0031589 ! cell-substrate adhesion
intersection_of: part_of GO:0042710 ! biofilm formation
relationship: part_of GO:0042710 ! biofilm formation
relationship: part_of GO:0090605 ! submerged biofilm formation

[Term]
id: GO:0043709
name: cell adhesion involved in single-species biofilm formation
namespace: biological_process
def: "The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species." [GOC:dph, GOC:jl, GOC:tb]
synonym: "cell adhesion during single-species biofilm formation" RELATED [GOC:dph, GOC:tb]
is_a: GO:0043708 ! cell adhesion involved in biofilm formation
intersection_of: GO:0031589 ! cell-substrate adhesion
intersection_of: part_of GO:0044010 ! single-species biofilm formation
relationship: part_of GO:0044010 ! single-species biofilm formation
relationship: part_of GO:0090609 ! single-species submerged biofilm formation

[Term]
id: GO:0043710
name: cell adhesion involved in multi-species biofilm formation
namespace: biological_process
def: "The attachment of a cell to a solid substrate, via cell adhesion molecules, contributing to the formation of a biofilm composed of microorganisms of different species." [GOC:dph, GOC:jl, GOC:tb]
synonym: "cell adhesion during multi-species biofilm formation" RELATED [GOC:dph, GOC:tb]
is_a: GO:0043708 ! cell adhesion involved in biofilm formation
intersection_of: GO:0031589 ! cell-substrate adhesion
intersection_of: part_of GO:0044399 ! multi-species biofilm formation
relationship: part_of GO:0044399 ! multi-species biofilm formation
relationship: part_of GO:0090608 ! multi-species submerged biofilm formation

[Term]
id: GO:0043711
name: pilus organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pilus, a short filamentous structure on a bacterial cell, flagella-like in structure and generally present in many copies." [GOC:jl]
subset: gosubset_prok
synonym: "pilus organisation" EXACT [GOC:mah]
synonym: "pilus organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0030030 ! cell projection organization

[Term]
id: GO:0043712
name: 2-hydroxyisocaproate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-2-hydroxyisocaproate + isocaproyl-CoA = (R)-2-hydroxyisocaproyl-CoA + isocaproate." [PMID:16957230]
synonym: "(R)-2-hydroxyisocaproate CoA transferase activity" EXACT []
synonym: "(R)-2-hydroxyisocaproate CoA-transferase activity" EXACT []
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0043713
name: (R)-2-hydroxyisocaproate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoisocaproate + NADH + H+ = (R)-2-hydroxyisocaproate + NAD+." [GOC:jl, PMID:16957230]
subset: gosubset_prok
xref: EC:1.1.1.-
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0043714
name: (R)-citramalate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyruvate + acetyl-CoA + H2O = (R)-citramalate + CoA." [GOC:jl, PMID:9864346]
subset: gosubset_prok
synonym: "citramalate synthase" BROAD []
xref: EC:2.3.3.-
xref: MetaCyc:RXN-7743
is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

[Term]
id: GO:0043715
name: 2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-diketo-5-methylthiopentyl-1-phosphate = H+ + 2-hydroxy 3-keto-5-methylthiopentenyl-1-phosphate. 2,3-diketo-5-methylthiopentyl-1-phosphate is also known as DK-MTP-1-P, and 2-hydroxy 3-keto-5-methylthiopentenyl-1-phosphate as HK-MTPenyl-1-P." [MetaCyc:R82-RXN]
comment: This function is part of the process of methionine salvage.
subset: gosubset_prok
synonym: "DK-MTP-1-P enolase activity" EXACT []
synonym: "E-1" RELATED []
synonym: "MasA" RELATED []
synonym: "mtnW" RELATED []
xref: EC:5.3.2.-
xref: MetaCyc:R82-RXN
is_a: GO:0016862 ! intramolecular oxidoreductase activity, interconverting keto- and enol-groups

[Term]
id: GO:0043716
name: 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate. 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate is also known as HK-MTPenyl-P, and 1,2-dihydroxy-3-keto-5-methylthiopentene as DHK-MTPene." [EC:3.1.3.77, IMG:01681, MetaCyc:R83-RXN]
subset: gosubset_prok
synonym: "2-hydroxy-3-keto-5-methylthio-phosphopentene phosphatase activity" EXACT [MetaCyc:R83-RXN]
synonym: "HK-MTPenyl-1-P phosphatase activity" EXACT []
xref: KEGG:R07394
xref: MetaCyc:R83-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0043717
name: 2-hydroxyglutaryl-CoA dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-2-hydroxyglutaryl-CoA = H2O + glutaconyl-CoA." [MetaCyc:RXN-1083]
subset: gosubset_prok
synonym: "(R)-2-hydroxyglutaryl-CoA dehydratase activity" EXACT []
xref: MetaCyc:RXN-1083
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0043718
name: 2-hydroxymethylglutarate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-(hydroxymethyl)glutarate + NAD(+) = 2-formylglutarate + H(+) + NADH." [EC:1.1.1.291, RHEA:15508]
subset: gosubset_prok
synonym: "(S)-2-hydroxymethylglutarate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.291]
synonym: "HgD" EXACT []
xref: EC:1.1.1.291
xref: KEGG:R07985
xref: MetaCyc:1.1.1.291-RXN
xref: RHEA:15508
xref: Wikipedia:2-hydroxymethylglutarate_dehydrogenase
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0043719
name: 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol + O2 + H+ = 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol + H2O." [GOC:jl, MetaCyc:OCTAPRENYL-METHYL-METHOXY-BENZOQ-OH-RXN]
subset: gosubset_prok
xref: EC:1.14.13.-
xref: MetaCyc:OCTAPRENYL-METHYL-METHOXY-BENZOQ-OH-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0043720
name: 3-keto-5-aminohexanoate cleavage activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-keto-5-aminohexanoate + acetyl-CoA = L-3-aminobutyryl-CoA + acetoacetate." [MetaCyc:R125-RXN, PMID:13064]
subset: gosubset_prok
synonym: "3-keto-5-aminohexanoate cleavage enzyme" EXACT []
xref: MetaCyc:R125-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0043721
name: 4-hydroxybutanoyl-CoA dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxybutanoyl-CoA = vinylacetyl-CoA + H2O." [EC:4.2.1.120]
subset: gosubset_prok
synonym: "4-hydroxybutanoyl-CoA hydro-lyase" EXACT []
synonym: "4-hydroxybutyryl-CoA dehydratase activity" EXACT []
synonym: "gamma-hydroxybutanoyl-CoA dehydratase activity" EXACT []
synonym: "gamma-hydroxybutyryl-CoA dehydratase activity" EXACT []
xref: EC:4.2.1.120
xref: KEGG:R05337
xref: MetaCyc:RXN-8890
xref: RHEA:26533
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0043722
name: 4-hydroxyphenylacetate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: (4-hydroxyphenyl)acetate + H(+) = 4-cresol + CO(2)." [EC:4.1.1.83, RHEA:22735]
subset: gosubset_prok
synonym: "4-(hydroxyphenyl)acetate carboxy-lyase (4-methylphenol-forming)" EXACT [EC:4.1.1.83]
synonym: "4-Hpd activity" EXACT [EC:4.1.1.83]
synonym: "4-hydroxyphenylacetate carboxy-lyase activity" EXACT [EC:4.1.1.83]
synonym: "p-Hpd activity" EXACT [EC:4.1.1.83]
synonym: "p-hydroxyphenylacetate decarboxylase activity" EXACT [EC:4.1.1.83]
xref: EC:4.1.1.83
xref: KEGG:R07312
xref: MetaCyc:4.1.1.83-RXN
xref: RHEA:22735
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0043723
name: 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase activity
namespace: molecular_function
alt_id: GO:0017173
def: "Catalysis of the reaction: 2,5-diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one + H2O = 5-amino-6-(5-phospho-D-ribosylamino)uracil + ammonia." [MetaCyc:RXN-10058, PMID:11889103]
subset: gosubset_prok
synonym: "2,5-diamino-6-(5-phosphoribitylamino)pyrimidin-4(3H)-one deaminase activity" EXACT [MetaCyc:YOL066C-MONOMER]
synonym: "DRAP deaminase activity" EXACT []
xref: EC:3.5.4.-
xref: MetaCyc:RXN-10058
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines

[Term]
id: GO:0043724
name: 2-keto-3-deoxygalactonate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-keto-3-deoxygalactonate = D-glyceraldehyde + pyruvate." [PMID:12824170]
subset: gosubset_prok
synonym: "KDGal aldolase activity" EXACT []
xref: EC:4.2.1.-
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0043725
name: 2-keto-3-deoxygluconate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-keto-3-deoxygluconate = D-glyceraldehyde + pyruvate." [PMID:12824170]
subset: gosubset_prok
synonym: "KDG aldolase activity" EXACT []
xref: EC:4.2.1.-
xref: MetaCyc:DHDOGALDOL-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0043726
name: 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity
namespace: molecular_function
alt_id: GO:0019173
def: "Catalysis of the reaction: 5-amino-6-(5-phosphoribitylamino)-2,4(1H,3H)-pyrimidinedione + H2O = 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione + orthophosphate." [GOC:jl, IMG:01282]
subset: gosubset_prok
synonym: "pyrimidine phosphatase activity" EXACT [GOC:mah]
xref: EC:3.1.3.-
xref: MetaCyc:RIBOPHOSPHAT-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0043727
name: 5-amino-4-imidazole carboxylate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-aminoimidazole + CO2 = 5-amino-4-imidazole carboxylate." [GOC:jl, IMG:01835]
subset: gosubset_prok
xref: EC:4.1.1.-
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0043728
name: 2-keto-4-methylthiobutyrate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-keto-4-methylthiobutyrate + L-glutamine = 2-oxoglutaramate + L-methionine." [GOC:jl, IMG:01683]
subset: gosubset_prok
xref: EC:4.1.1.-
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0043729
name: 2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one formate-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one + H2O = 2,5-diamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one + formate." [GOC:jl, IMG:01536]
subset: gosubset_prok
xref: EC:4.-.-.-
is_a: GO:0016829 ! lyase activity

[Term]
id: GO:0043730
name: 5-ureido-4-imidazole carboxylate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-ureido-4-imidazole carboxylate + H2O = 5-amino-4-imidazole carboxylate + NH3 + CO2." [GOC:jl, IMG:02121]
subset: gosubset_prok
xref: EC:3.5.3.-
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0043731
name: 6-hydroxynicotinate 3-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the oxidative decarboxylation of 6-hydroxynicotinate to 2,5-dihydroxypyridine, dependent on O2, NADH +H+ and FAD." [GOC:jl, PMID:10091591]
subset: gosubset_prok
xref: EC:1.14.13.-
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0043732
name: 6-hydroxynicotinate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-hydroxynicotinate + H(2)O + O(2) = 2,6-dihydroxynicotinate + H(2)O(2)." [EC:1.17.3.3, RHEA:22811]
subset: gosubset_prok
synonym: "6-hydroxynicotinate hydroxylase activity" EXACT [EC:1.17.3.3]
synonym: "6-hydroxynicotinate:O2 oxidoreductase activity" EXACT [EC:1.17.3.3]
synonym: "6-hydroxynicotinic acid dehydrogenase activity" EXACT [EC:1.17.3.3]
synonym: "6-hydroxynicotinic acid hydroxylase activity" EXACT [EC:1.17.3.3]
xref: EC:1.17.3.3
xref: KEGG:R07221
xref: MetaCyc:RXN-7585
xref: RHEA:22811
is_a: GO:0016727 ! oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor

[Term]
id: GO:0043733
name: DNA-3-methylbase glycosylase activity
namespace: molecular_function
def: "Catalysis of the reaction: DNA containing 3-methylbase + H2O = DNA with abasic site + 3-methylbase. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methylpurine or 3-methylpyrimidine base and the deoxyribose sugar to remove the methylated base, leaving an apurinic or apyrimidinic site." [IMG:00576, PMID:10777493, PMID:14517230]
subset: gosubset_prok
synonym: "DNA-3-methyladenine glycosylase III" RELATED []
synonym: "Mag III" NARROW []
synonym: "MagIII" NARROW []
xref: EC:3.2.2.-
xref: IMG:00576
is_a: GO:0003905 ! alkylbase DNA N-glycosylase activity

[Term]
id: GO:0043734
name: DNA-N1-methyladenine dioxygenase activity
namespace: molecular_function
def: "Catalysis of the oxidative demethylation of N1-methyladenine and N3-methylcytosine in DNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N1-methyladenine and N3-methylcytosine as formaldehyde." [IMG:00579, PMID:19786499]
subset: gosubset_prok
subset: mf_needs_review
synonym: "AlkB" NARROW []
synonym: "alpha-ketoglutarate-dependent dioxygenase" NARROW []
xref: EC:1.14.11.-
xref: Reactome:REACT_115853 "Reversal of Alkylation Damage By DNA Dioxygenases, Gallus gallus"
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0043736
name: obsolete DNA-3-methyladenine glycosylase IV activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of alkylated DNA; recognizes and removes both N-3- and N-7-methyl purines by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site." [IMG:00578, PMID:10375529]
comment: This term was made obsolete because it represents an enzyme with four different activities.
subset: gosubset_prok
synonym: "DNA-3-methyladenine glycosylase IV activity" EXACT []
synonym: "Mpg II" NARROW []
synonym: "MpgII" NARROW []
is_obsolete: true
consider: GO:0008725
consider: GO:0043916
consider: GO:0052821
consider: GO:0052822

[Term]
id: GO:0043737
name: deoxyribonuclease V activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate." [EC:3.1.21.7]
synonym: "DNase V activity" EXACT [EC:3.1.21.7]
synonym: "endodeoxyribonuclease V" EXACT []
synonym: "endonuclease V activity" BROAD [EC:3.1.21.7]
synonym: "Escherichia coli endodeoxyribonuclease V activity" NARROW [EC:3.1.21.7]
xref: EC:3.1.21.7
xref: MetaCyc:3.1.21.7-RXN
is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0043738
name: reduced coenzyme F420 dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: methanophenazine + reduced coenzyme F420 = dihydromethanophenazine + coenzyme F420." [MetaCyc:RXN-8106]
subset: gosubset_prok
synonym: "1,5-dihydrocoenzyme F420 dehydrogenase activity" EXACT [CHEBI:15823]
synonym: "F420H2 dehydrogenase activity" EXACT []
xref: EC:1.-.-.-
xref: MetaCyc:RXN-8106
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0043739
name: G/U mismatch-specific uracil-DNA glycosylase activity
namespace: molecular_function
def: "Catalysis of the removal of uracil from a U*G mispair by the cleavage the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free uracil and leaves an apyrimidinic (AP) site." [IMG:00570, SP:O59825]
subset: gosubset_prok
synonym: "GU mismatch-specific uracil-DNA glycosylase activity" EXACT []
synonym: "MUG" EXACT []
synonym: "uracil mismatch repair protein" BROAD []
is_a: GO:0004844 ! uracil DNA N-glycosylase activity
is_a: GO:0008263 ! pyrimidine-specific mismatch base pair DNA N-glycosylase activity

[Term]
id: GO:0043740
name: GTP cyclohydrolase IIa activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP + 3 H(2)O = 2-amino-5-formylamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + 3 H(+) + 2 phosphate." [EC:3.5.4.29, RHEA:22471]
subset: gosubset_prok
synonym: "GTP 8,9-dihydrolase (phosphate-forming)" EXACT [EC:3.5.4.29]
synonym: "GTP 8,9-hydrolase (phosphate-forming)" EXACT []
synonym: "GTP cyclohydrolase III activity" NARROW [EC:3.5.4.29]
xref: EC:3.5.4.29
xref: KEGG:R07306
xref: MetaCyc:RXN-10055
xref: RHEA:22471
is_a: GO:0003933 ! GTP cyclohydrolase activity

[Term]
id: GO:0043741
name: L-2-aminoadipate N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-2-aminoadipate + acetyl-CoA = N2-acetyl-L-aminoadipate + CoA." [IMG:01447]
subset: gosubset_prok
xref: EC:2.3.1.-
xref: MetaCyc:RXN-5181
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0043743
name: LPPG:FO 2-phospho-L-lactate transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7,8-didemethyl-8-hydroxy-5-deazariboflavin + lactyl-2-diphospho-5'-guanosine = coenzyme F420-0 + GMP." [IMG:01551]
subset: gosubset_prok
xref: EC:2.7.1.-
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0043744
name: N2-acetyl-L-aminoadipate kinase activity
namespace: molecular_function
alt_id: GO:0043868
def: "Catalysis of the reaction: ATP + N-acetyl-L-aminoadipate = ADP + N-acetyl-L-aminoadipate 5-phosphate." [IMG:01448]
subset: gosubset_prok
synonym: "acetylaminoadipate kinase activity" EXACT []
synonym: "LysZ" RELATED []
synonym: "N-acetyl-L-aminoadipate 5-phosphotransferase activity" EXACT []
synonym: "N-acetylaminoadipate kinase activity" EXACT []
xref: EC:2.7.2.-
xref: MetaCyc:RXN-5182
is_a: GO:0016301 ! kinase activity
is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor

[Term]
id: GO:0043745
name: N2-acetyl-L-aminoadipate semialdehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: N2-acetyl-L-aminoadipyl-delta-phosphate + NADPH + H+ = N2-acetyl-L-aminoadipate semialdehyde + NADP+ + orthophosphate." [IMG:01449]
subset: gosubset_prok
xref: EC:1.2.1.-
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0043746
name: N2-acetyl-L-lysine aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N2-acetyl-L-aminoadipate semialdehyde + L-glutamate = 2-oxoglutarate + N2-acetyl-L-lysine." [IMG:01450]
subset: gosubset_prok
synonym: "N-acetyl-lysine aminotransferase activity" EXACT []
xref: EC:2.6.1.-
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0043747
name: N2-acetyl-L-lysine deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N2-acetyl-L-lysine + H2O = acetate + L-lysine." [IMG:01451]
subset: gosubset_prok
synonym: "N-acetyl-lysine deacetylase activity" EXACT []
xref: EC:3.5.1.-
xref: MetaCyc:RXN-5185
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0043748
name: O-succinylbenzoate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-succinylbenzoate + H2O = 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate." [IMG:01733]
subset: gosubset_prok
xref: EC:3.5.1.-
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0043749
name: phenol, water dikinase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenol + MgATP + H2O = phenylphosphate + MgAMP + orthophosphate." [PMID:15547277]
subset: gosubset_prok
synonym: "ATP:phenol:water phosphotransferase activity" EXACT []
synonym: "phenol:water dikinase activity" EXACT []
synonym: "phenylphosphate synthase activity" EXACT []
xref: EC:2.7.9.-
is_a: GO:0016301 ! kinase activity
is_a: GO:0016781 ! phosphotransferase activity, paired acceptors

[Term]
id: GO:0043750
name: phosphatidylinositol alpha-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of one or more alpha-D-mannose residues from GDP-mannose to positions 2,6 and others in 1-phosphatidyl-myo-inositol." [EC:2.4.1.57]
subset: gosubset_prok
synonym: "GDP mannose-phosphatidyl-myo-inositol alpha-mannosyltransferase activity" EXACT [EC:2.4.1.57]
synonym: "GDP mannose:1-phosphatidyl-myo-inositol alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.57]
synonym: "GDP-mannose:1-phosphatidyl-1D-myo-inositol alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.57]
synonym: "GDPmannose:1-phosphatidyl-myo-inositol alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.57]
synonym: "guanosine diphosphomannose-phosphatidyl-inositol alpha-mannosyltransferase activity" EXACT [EC:2.4.1.57]
synonym: "phosphatidyl-myo-inositol alpha-mannosyltransferase activity" EXACT [EC:2.4.1.57]
xref: EC:2.4.1.57
xref: MetaCyc:2.4.1.57-RXN
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0043751
name: polyphosphate:AMP phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (polyphosphate)n + AMP = (polyphosphate)n-1 + ADP." [PMID:11237733]
subset: gosubset_prok
synonym: "PAP" EXACT []
synonym: "PPT" BROAD []
xref: EC:2.7.4.-
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor

[Term]
id: GO:0043752
name: adenosylcobinamide kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: RTP + adenosylcobinamide = adenosylcobinamide phosphate + RDP (where RTP is either ATP or GTP)." [EC:2.7.1.156]
subset: gosubset_prok
synonym: "adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase" BROAD []
synonym: "AdoCbi kinase/AdoCbi-phosphate guanylyltransferase" BROAD []
synonym: "CobU" RELATED []
synonym: "RTP:adenosylcobinamide phosphotransferase activity" EXACT []
xref: EC:2.7.1.156
xref: MetaCyc:2.7.1.156-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0043754
name: dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-methylpropanoyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-[2-methylpropanoyl]dihydrolipoyl)lysine." [EC:2.3.1.168]
subset: gosubset_prok
synonym: "2-methylpropanoyl-CoA:enzyme-6-N-(dihydrolipoyl)lysine:S-(2-methylpropanoyl)transferase activity" EXACT [EC:2.3.1.168]
synonym: "2-methylpropanoyl-CoA:enzyme-N6-(dihydrolipoyl)lysine:S-(2-methylpropanoyl)transferase activity" EXACT [EC:2.3.1.168]
synonym: "dihydrolipoyl transacylase activity" EXACT [EC:2.3.1.168]
synonym: "enzyme-dihydrolipoyllysine:2-methylpropanoyl-CoA S-(2-methylpropanoyl)transferase activity" EXACT []
xref: EC:2.3.1.168
xref: MetaCyc:2.3.1.168-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0043755
name: alpha-ribazole phosphatase activity
namespace: molecular_function
alt_id: GO:0019175
def: "Catalysis of the reaction: alpha-ribazole 5'-phosphate + H(2)O = alpha-ribazole + phosphate." [EC:3.1.3.73, RHEA:24459]
subset: gosubset_prok
synonym: "alpha-ribazole-5'-P phosphatase activity" EXACT []
synonym: "alpha-ribazole-5'-phosphate phosphohydrolase activity" EXACT []
synonym: "CobC" RELATED []
xref: EC:3.1.3.73
xref: KEGG:R04594
xref: MetaCyc:RIBAZOLEPHOSPHAT-RXN
xref: RHEA:24459
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0043756
name: adenosylcobinamide hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: adenosylcobinamide + H(2)O = (R)-1-aminopropan-2-ol + adenosylcobyrate." [EC:3.5.1.90, RHEA:23507]
subset: gosubset_prok
synonym: "adenosylcobinamide amidohydrolase activity" EXACT [EC:3.5.1.90]
synonym: "AdoCbi amidohydrolase activity" EXACT [EC:3.5.1.90]
synonym: "AdoCbi hydrolase activity" EXACT [EC:3.5.1.90]
synonym: "CbiZ" RELATED []
xref: EC:3.5.1.90
xref: KEGG:R05226
xref: MetaCyc:R346-RXN
xref: RHEA:23507
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0043757
name: adenosylcobinamide-phosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reactions: ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate = ADP + phosphate + adenosylcobinamide phosphate, and ATP + adenosylcobyric acid + (R)-1-aminopropan-2-ol = ADP + phosphate + adenosylcobinamide." [EC:6.3.1.10]
subset: gosubset_prok
synonym: "adenosylcobyric acid:(R)-1-aminopropan-2-yl phosphate ligase (ADP-forming)" EXACT []
synonym: "AdoCbi-P synthase activity" EXACT [EC:6.3.1.10]
synonym: "CbiB" RELATED []
xref: EC:6.3.1.10
xref: MetaCyc:RXN-6261
is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity

[Term]
id: GO:0043758
name: acetate-CoA ligase (ADP-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + acetate + CoA = ADP + phosphate + acetyl-CoA." [EC:6.2.1.13]
subset: gosubset_prok
synonym: "acetate thiokinase activity" BROAD [EC:6.2.1.13]
synonym: "acetate--CoA ligase (ADP-forming) activity" EXACT []
synonym: "acetate:CoA ligase (ADP-forming)" EXACT [EC:6.2.1.13]
synonym: "acetyl coenzyme A synthetase (adenosine diphosphate-forming)" EXACT []
synonym: "acetyl-CoA synthetase (ADP-forming) activity" EXACT [EC:6.2.1.13]
xref: EC:6.2.1.13
xref: MetaCyc:ACETATE--COA-LIGASE-ADP-FORMING-RXN
xref: RHEA:15084
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0043759
name: branched-chain acyl-CoA synthetase (ADP-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 2-methylbutanoate + CoA = ADP + orthophosphate + 2-methylbutanoyl-CoA." [IMG:01425]
subset: gosubset_prok
synonym: "branched chain acyl CoA synthetase (ADP-forming) activity" EXACT []
synonym: "branched chain acyl-CoA synthetase (ADP-forming) activity" EXACT []
synonym: "branched-chain acyl CoA synthetase (ADP-forming) activity" EXACT []
xref: EC:6.2.1.-
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0043760
name: acetyldiaminopimelate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate = N-acetyl-2-L-amino-6-oxoheptanedioate + L-glutamate." [IMG:00444, PMID:1906065]
subset: gosubset_prok
synonym: "N-acetyl-diaminopimelate aminotransferase activity" EXACT []
synonym: "N-acetyl-L,L-diaminopimelate aminotransferase activity" EXACT []
xref: EC:2.6.1.-
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0043761
name: archaetidylserine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: CDP-digeranylgeranylglycerol + L-serine = archaetidylserine + CMP." [IMG:01567, PMID:12562787]
subset: gosubset_prok
synonym: "CDP-2,3-di-O-geranylgeranyl-sn-glycerol inositol 1-archaetidyltransferase activity" EXACT []
synonym: "CDP-2,3-di-O-geranylgeranyl-sn-glycerol:l-serine O-archaetidyltransferase activity" EXACT []
xref: EC:2.7.8.-
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0043762
name: aryl-CoA synthetase (ADP-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + phenylacetate + CoA = ADP + orthophosphate + phenylacetyl-CoA." [IMG:01427]
subset: gosubset_prok
xref: EC:6.2.1.-
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0043763
name: UTP:glucose-1-phosphate uridylyltransferase regulator activity
namespace: molecular_function
def: "Modulates the activity of UTP:glucose-1-phosphate uridylyltransferase." [GOC:jl]
subset: gosubset_prok
synonym: "glucose-1-phosphate uridylyltransferase regulator activity" EXACT []
synonym: "UDP-glucose diphosphorylase regulator activity" EXACT []
synonym: "UDP-glucose pyrophosphorylase regulator activity" EXACT []
is_a: GO:0030234 ! enzyme regulator activity
relationship: regulates GO:0003983 ! UTP:glucose-1-phosphate uridylyltransferase activity

[Term]
id: GO:0043764
name: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-3-O-(3-hydroxytetradecanoyl)glucosamine + (R)-3-hydroxytetradecanoyl-[acyl-carrier protein] = UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + [acyl-carrier protein]." [IMG:00545, InterPro:IPR007691]
subset: gosubset_prok
xref: EC:2.3.1.191
xref: MetaCyc:UDPHYDROXYMYRGLUCOSAMNACETYLTRANS-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0043765
name: T/G mismatch-specific endonuclease activity
namespace: molecular_function
def: "Catalysis of the repair of T/G mismatches arising from deamination of 5-methylcytosine in DNA by nicking double-stranded DNA within the sequence CT(AT)GN or NT(AT)GG next to the mismatched thymidine residue. The incision is mismatch-dependent and strand-specific, in favor of the G-containing strand. The incision serves as a starting point for subsequent excision repair by DNA polymerase I, which excises thymidine and reinserts cytidine." [IMG:00606, SP:P09184]
subset: gosubset_prok
synonym: "DNA mismatch endonuclease" BROAD []
synonym: "V.EcoKDcm" RELATED []
synonym: "very short patch repair protein" RELATED []
synonym: "Vsr mismatch endonuclease" RELATED []
xref: EC:3.1.-.-
is_a: GO:0004519 ! endonuclease activity

[Term]
id: GO:0043766
name: Sep-tRNA:Cys-tRNA synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: O-phospho-L-seryl-tRNACys + sulfide = L-cysteinyl-tRNACys + phosphate." [EC:2.5.1.73, IMG:00235, PMID:15790858, PMID:16380427, PMID:17110438]
subset: gosubset_prok
synonym: "O-phosphoseryl-tRNA:cysteinyl-tRNA synthase activity" EXACT []
synonym: "Sep-tRNA:Cys-tRNA synthetase activity" EXACT []
synonym: "SepCysS" RELATED []
xref: EC:2.5.1.73
xref: MetaCyc:RXN-10719
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups
relationship: part_of GO:0071952 ! conversion of O-phosphoseryl-tRNA to cysteinyl-tRNA

[Term]
id: GO:0043767
name: pyrrolysyl-tRNA synthetase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-pyrrolysine + tRNA(Pyl) = AMP + diphosphate + L-pyrrolysyl-tRNA(Pyl)." [IMG:02553, PMID:15314242, SP:Q8TUB8]
subset: gosubset_prok
synonym: "PylRS" EXACT []
synonym: "Pyrrolysine-tRNA ligase activity" EXACT []
xref: EC:6.1.1.-
xref: MetaCyc:6.1.1.26-RXN
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0043768
name: S-ribosylhomocysteine lyase activity
namespace: molecular_function
alt_id: GO:0019138
def: "Catalysis of the reaction: S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine." [EC:4.4.1.21, RHEA:17756]
subset: gosubset_prok
synonym: "3.2.1.148" RELATED []
synonym: "LuxS" RELATED []
synonym: "ribosylhomocysteinase activity" EXACT []
synonym: "S-(5-deoxy-D-ribos-5-yl)-L-homocysteine homocysteine-lyase [(4S)-4,5-dihydroxypentan-2,3-dione-forming]" RELATED [EC:4.4.1.21]
synonym: "S-ribosylhomocysteinase activity" EXACT []
xref: EC:4.4.1.21
xref: KEGG:R01291
xref: MetaCyc:RIBOSYLHOMOCYSTEINASE-RXN
xref: RHEA:17756
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0043769
name: Tpg-containing telomere binding complex
namespace: cellular_component
def: "A complex composed of four polypeptides, a telomere-protecting terminal protein (Tpg), a telomere-associated protein (Tap), DNA polymerase (PolA) and topoisomerase I (TopA), that functions in the replication of the telomeric regions of linear chromosomes, plasmids and circular replicons of some bacterial species." [PMID:15353591]
subset: gosubset_prok
synonym: "telomere complex" BROAD []
is_a: GO:0000782 ! telomere cap complex

[Term]
id: GO:0043770
name: demethylmenaquinone methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-demethylmenaquinone + S-adenosyl-L-methionine = menaquinone + S-adenosyl-L-homocysteine." [IMG:01848]
subset: gosubset_prok
xref: EC:2.1.1.-
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0043771
name: cytidine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + cytidine = ADP + CMP." [IMG:01870]
subset: gosubset_prok
xref: EC:2.7.1.-
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019206 ! nucleoside kinase activity
relationship: part_of GO:0009224 ! CMP biosynthetic process

[Term]
id: GO:0043772
name: acyl-phosphate glycerol-3-phosphate acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl phosphate + sn-glycerol 3-phosphate = 1-acyl-sn-glycerol 3-phosphate + orthophosphate." [IMG:01872, PMID:17308305]
subset: gosubset_prok
synonym: "acyl-phosphate:glycerol-3-phosphate acyltransferase activity" EXACT []
synonym: "acylphosphate glycerol-3-phosphate acyltransferase activity" EXACT []
synonym: "acylphosphate:glycerol-3-phosphate acyltransferase activity" EXACT []
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0043773
name: coenzyme F420-0 gamma-glutamyl ligase activity
namespace: molecular_function
def: "Catalysis of the reactions: (1) GTP + F420-0 + L-glutamate = GDP + phosphate + F420-1, and (2) GTP + F420-1 + L-glutamate = GDP + phosphate + gamma-F420-2. This is the GTP-dependent successive addition of two L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form F420-0-glutamyl-glutamate (F420-2), with a gamma-linkage between the two glutamates." [IMG:01552, PMID:17669425]
subset: gosubset_prok
synonym: "F420-0 gamma-glutamyl ligase activity" EXACT []
xref: EC:6.3.2.-
is_a: GO:0016881 ! acid-amino acid ligase activity
relationship: has_part GO:0052618 ! coenzyme F420-0:L-glutamate ligase activity
relationship: has_part GO:0052619 ! coenzyme F420-1:gamma-L-glutamate ligase activity

[Term]
id: GO:0043774
name: coenzyme F420-2 alpha-glutamyl ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: coenzyme F420-2 + L-glutamate + GTP = coenzyme F420-3 + GDP + orthophosphate." [IMG:01553]
subset: gosubset_prok
synonym: "F420-2 alpha-glutamyl ligase activity" EXACT []
xref: EC:6.3.2.-
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0043775
name: cobyrinate a,c-diamide synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: cobyrinate + 2 L-glutamine + 2 ATP + 2 H2O = cob(II)yrinate a,c-diamide + 2 L-glutamate + 2 ADP + 2 orthophosphate." [IMG:01814]
subset: gosubset_prok
synonym: "cobyrinate a c diamide synthase activity" EXACT []
synonym: "cobyrinate a c-diamide synthase activity" EXACT []
synonym: "cobyrinate a,c diamide synthase activity" EXACT []
xref: EC:6.3.5.-
is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor

[Term]
id: GO:0043776
name: cobalt-precorrin-6B C5-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosylmethionine + cobalt-precorrin 6B = S-adenosylhomocysteine + cobalt-precorrin 7." [IMG:02115, MetaCyc:RXN-8766]
subset: gosubset_prok
synonym: "cobalt-precorrin 6B C5-methyltransferase activity" EXACT []
synonym: "precorrin-6 methyltransferase activity" EXACT []
synonym: "precorrin-6Y C5,15-methyltransferase (decarboxylating)" BROAD []
synonym: "precorrin-6Y methylase" BROAD []
xref: EC:2.1.1.-
xref: MetaCyc:RXN-8766
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0043777
name: cobalt-precorrin-7 C15-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: cobalt-precorrin 7 + S-adenosyl-L-methionine = cobalt-precorrin 8 + S-adenosyl-L-homocysteine + CO2." [IMG:02116, MetaCyc:RXN-8767]
subset: gosubset_prok
synonym: "cobalt-precorrin 7 C15-methyltransferase activity" EXACT []
synonym: "precorrin-6 methyltransferase" BROAD []
synonym: "precorrin-6Y C5,15-methyltransferase (decarboxylating)" BROAD []
synonym: "precorrin-6Y methylase" BROAD []
xref: EC:2.1.1.-
xref: MetaCyc:RXN-8767
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0043778
name: cobalt-precorrin-8 methylmutase activity
namespace: molecular_function
def: "Catalysis of the reaction: cobalt-precorrin 8 = cobyrinate." [IMG:02117, MetaCyc:RXN-8768]
subset: gosubset_prok
synonym: "cobalt-precorrin 8 methylmutase activity" EXACT []
synonym: "cobalt-precorrin 8X methylmutase activity" EXACT []
synonym: "cobalt-precorrin-8X methylmutase activity" EXACT []
xref: EC:5.4.1.-
xref: MetaCyc:RXN-8768
is_a: GO:0016867 ! intramolecular transferase activity, transferring acyl groups

[Term]
id: GO:0043779
name: cobalt-precorrin-5A acetaldehyde-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: cobalt-precorrin 5A + H2O = cobalt-precorrin 5B + acetaldehyde." [IMG:02112, MetaCyc:RXN-8763]
subset: gosubset_prok
synonym: "cobalt-precorrin 5A acetaldehyde-lyase activity" EXACT []
xref: MetaCyc:RXN-8763
is_a: GO:0016829 ! lyase activity

[Term]
id: GO:0043780
name: cobalt-precorrin-5B C1-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: cobalt-precorrin 5B + S-adenosylmethionine = S-adenosylhomocysteine + cobalt-precorrin 6A." [IMG:02112, MetaCyc:RXN-8764]
subset: gosubset_prok
synonym: "cobalt-precorrin 5B C1-methyltransferase activity" EXACT []
xref: EC:2.1.1.-
xref: MetaCyc:RXN-8764
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0043781
name: cobalt-factor II C20-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + cobalt-factor II = S-adenosyl-L-homocysteine + cobalt-factor III." [EC:2.1.1.151, IMG:01812]
subset: gosubset_prok
synonym: "CbiL" NARROW []
synonym: "cobalt-factor II C20 methyltransferase activity" EXACT []
synonym: "cobalt-precorrin-2 C(20)-methyltransferase activity" EXACT [EC:2.1.1.151]
synonym: "S-adenosyl-L-methionine:cobalt-factor-II C20-methyltransferase activity" EXACT [EC:2.1.1.151]
xref: EC:2.1.1.151
xref: MetaCyc:RXN-8760
xref: RHEA:18000
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0043782
name: cobalt-precorrin-3 C17-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: cobalt-precorrin 3 + S-adenosyl-L-methionine = cobalt-precorrin 4 + S-adenosyl-L-homocysteine." [IMG:02110, MetaCyc:RXN-8761]
subset: gosubset_prok
synonym: "cobalt-precorrin 3 C17-methyltransferase activity" EXACT []
synonym: "cobalt-precorrin-3 methylase" BROAD []
synonym: "cobalt-precorrin-3 methyltransferase" BROAD []
synonym: "cobalt-precorrin-3B C17-methyltransferase activity" EXACT []
xref: EC:2.1.1.-
xref: MetaCyc:RXN-8761
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0043783
name: oxidoreductase activity, oxidizing metal ions with flavin as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered and flavin acts as an electron acceptor." [EC:1.16.8]
subset: gosubset_prok
xref: EC:1.16.8
is_a: GO:0016722 ! oxidoreductase activity, oxidizing metal ions

[Term]
id: GO:0043784
name: cob(II)yrinic acid a,c-diamide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 cob(I)yrinate a,c diamide + FMN + 3 H(+) = 2 cob(II)yrinate a,c diamide + FMNH(2)." [EC:1.16.8.1, RHEA:24303]
subset: gosubset_prok
synonym: "cob(II)yrinic acid-a,c-diamide:FMN oxidoreductase activity" EXACT []
xref: EC:1.16.8.1
xref: KEGG:R05218
xref: MetaCyc:R343-RXN
xref: RHEA:24303
is_a: GO:0043783 ! oxidoreductase activity, oxidizing metal ions with flavin as acceptor

[Term]
id: GO:0043785
name: cinnamoyl-CoA:phenyllactate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-3-phenyllactate + [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonatooxy)oxolan-2-yl]methyl {[(3R)-3-hydroxy-2,2-dimethyl-3-({2-[(2-{[(2E)-3-phenylprop-2-enoyl]sulfanyl}ethyl)carbamoyl]ethyl}carbamoyl)propyl phosphonato]oxy}phosphonate = (R)-3-phenyllactoyl-CoA + trans-cinnamate." [EC:2.8.3.17, RHEA:15604]
subset: gosubset_prok
synonym: "(E)-cinnamoyl-CoA:(R)-phenyllactate CoA-transferase activity" EXACT []
synonym: "FldA" RELATED []
xref: EC:2.8.3.17
xref: KEGG:R07796
xref: MetaCyc:2.8.3.17-RXN
xref: RHEA:15604
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0043786
name: cinnamate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-phenylpropanoate + NAD+ = (E)-cinnamate + NADH + H+." [EC:1.3.1.-, IMG:01615, PMID:10849007]
subset: gosubset_prok
xref: EC:1.3.1.-
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0043791
name: dimethylamine methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: dimethylamine + a dimethylamine corrinoid protein = a methylated dimethylamine corrinoid protein + methylamine." [IMG:01321, MetaCyc:RXN-8100, PMID:9874228]
comment: This function is the first step in the pathway of methanogenesis from dimethylamine.
subset: gosubset_prok
synonym: "dimethylamine:corrinoid methyltransferase activity" EXACT []
synonym: "DMA methyltransferase 1" EXACT []
synonym: "DMAMT 1" EXACT []
synonym: "MT1" BROAD []
synonym: "mtbB1" RELATED []
xref: EC:2.1.1.-
xref: MetaCyc:RXN-8100
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0043792
name: enamidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,4,5,6-tetrahydro-6-oxonicotinate + 2 H(2)O = 2-formylglutarate + NH(4)(+)." [EC:3.5.2.18, RHEA:17212]
subset: gosubset_prok
synonym: "6-oxo-1,4,5,6-tetrahydronicotinate amidohydrolase activity" EXACT []
xref: EC:3.5.2.18
xref: KEGG:R07984
xref: MetaCyc:3.5.2.18-RXN
xref: RHEA:17212
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0043793
name: beta-ribofuranosylaminobenzene 5'-phosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-aminobenzoate + 5-phospho-alpha-D-ribose 1-diphosphate = 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + diphosphate." [GOC:jl, IMG:01544, PMID:12142414]
subset: gosubset_prok
synonym: "beta-RFAP synthase activity" EXACT []
xref: MetaCyc:RXN-8124
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0043794
name: formate dehydrogenase (coenzyme F420) activity
namespace: molecular_function
def: "Catalysis of the reaction: formate + coenzyme F420 = CO2 + reduced coenzyme F420." [IMG:01432, PMID:3801411]
subset: gosubset_prok
synonym: "formate dehydrogenase (F420) activity" EXACT []
xref: EC:1.2.99.-
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0043795
name: glyceraldehyde oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glyceraldehyde + H2O + acceptor = D-glycerate + reduced acceptor." [IMG:01506]
subset: gosubset_prok
xref: EC:1.2.-.-.
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0043796
name: glyceraldehyde dehydrogenase (NADP) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glyceraldehyde + H2O + NADP+ = D-glycerate + NADPH + H+." [IMG:01555]
subset: gosubset_prok
xref: EC:1.2.1.-
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0043797
name: glyceraldehyde-3-phosphate dehydrogenase (ferredoxin) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glyceraldehyde-3-phosphate + H2O + 2 oxidized ferredoxin = 3-phospho-D-glycerate + 2 H+ + 2 reduced ferredoxin." [EC:1.2.7.6]
subset: gosubset_prok
synonym: "D-glyceraldehyde-3-phosphate:ferredoxin oxidoreductase activity" EXACT []
synonym: "GAPOR" RELATED []
synonym: "glyceraldehyde-3-phosphate Fd oxidoreductase activity" EXACT [EC:1.2.7.6]
synonym: "glyceraldehyde-3-phosphate ferredoxin reductase activity" EXACT [EC:1.2.7.6]
xref: EC:1.2.7.6
xref: MetaCyc:1.2.7.6-RXN
is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0043798
name: glycerate 2-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glycerate + ATP = 2-phospho-D-glycerate + ADP." [IMG:01510, MetaCyc:GKI-RXN, PMID:14413719]
subset: gosubset_prok
synonym: "D-glycerate 2-kinase activity" EXACT []
synonym: "glycerate kinase" BROAD []
xref: EC:2.7.1.-
xref: MetaCyc:GKI-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016662 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor

[Term]
id: GO:0043799
name: glycine oxidase activity
namespace: molecular_function
def: "Catalysis of the reactions: (1) glycine + H2O + O2 = glyoxylate + NH3 + hydrogen peroxide; (2) D-alanine + H2O + O2 = pyruvate + NH3 + hydrogen peroxide; (3) sarcosine + H2O + O2 = glyoxylate + methylamine + hydrogen peroxide; (4) N-ethylglycine + H2O + O2 = glyoxylate + ethylamine + hydrogen peroxide." [EC:1.4.3.19]
subset: gosubset_prok
synonym: "glycine:oxygen oxidoreductase (deaminating)" EXACT []
xref: EC:1.4.3.19
xref: MetaCyc:1.4.3.19-RXN
xref: MetaCyc:RXN-8672
xref: MetaCyc:RXN-8673
xref: MetaCyc:RXN-8674
is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

[Term]
id: GO:0043800
name: hexulose-6-phosphate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-arabino-3-hexulose 6-phosphate = D-fructose 6-phosphate." [IMG:01502, MetaCyc:R12-RXN, PMID:11839305]
subset: gosubset_prok
synonym: "HUMPI" EXACT []
xref: EC:5.-.-.-
xref: MetaCyc:R12-RXN
is_a: GO:0016853 ! isomerase activity

[Term]
id: GO:0043801
name: hexulose-6-phosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-ribulose 5-phosphate + formaldehyde = D-arabino-3-hexulose 6-phosphate." [IMG:01503, PMID:16075199]
subset: gosubset_prok
xref: EC:4.1.2.-
xref: MetaCyc:R10-RXN
xref: RHEA:25204
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0043802
name: hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 L-glutamine + 2 ATP + 2 H(2)O + hydrogenobyrinate = 2 L-glutamate + 2 ADP + 4 H(+) + hydrogenobyrinate a,c-diamide + 2 phosphate." [EC:6.3.5.9, RHEA:12547]
subset: gosubset_prok
synonym: "CobB" RELATED []
synonym: "hydrogenobyrinic acid a,c diamide synthase (glutamine-hydrolysing) activity" EXACT []
synonym: "hydrogenobyrinic-acid:L-glutamine amido-ligase (AMP-forming)" EXACT []
xref: EC:6.3.5.9
xref: KEGG:R05224
xref: MetaCyc:R341-RXN
xref: RHEA:12547
is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor

[Term]
id: GO:0043803
name: hydroxyneurosporene-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: demethylspheroidene + S-adenosyl-L-methionine = spheroidene + S-adenosyl-L-homocysteine." [IMG:01759]
subset: gosubset_prok
xref: EC:2.1.1.-
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0043804
name: imidazolone hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-formiminoglycine = imidazolone + H2O." [IMG:02122]
subset: gosubset_prok
xref: EC:3.5.2.-
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0043805
name: indolepyruvate ferredoxin oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (indol-3-yl)pyruvate + CoA + oxidized ferredoxin = S-2-(indol-3-yl)acetyl-CoA + CO2 + reduced ferredoxin." [EC:1.2.7.8]
subset: gosubset_prok
synonym: "3-(indol-3-yl)pyruvate synthase (ferredoxin) activity" EXACT [EC:1.2.7.8]
synonym: "3-(indol-3-yl)pyruvate:ferredoxin oxidoreductase (decarboxylating, CoA-indole-acetylating)" EXACT [EC:1.2.7.8]
synonym: "indolepyruvate oxidoreductase activity" EXACT [EC:1.2.7.8]
synonym: "IOR" RELATED []
xref: EC:1.2.7.8
xref: MetaCyc:1.2.7.8-RXN
is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0043806
name: keto acid formate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxobutanoate + CoA = propionyl-CoA + formate." [IMG:00725, MetaCyc:KETOBUTFORMLY-RXN]
subset: gosubset_prok
synonym: "keto-acid formate acetyltransferase" BROAD []
synonym: "keto-acid formate lyase activity" EXACT []
synonym: "keto-acid formate-lyase activity" EXACT []
xref: EC:2.3.1.-
xref: MetaCyc:KETOBUTFORMLY-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0043807
name: 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-methyl-2-oxobutanoate + CoA + oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + reduced ferredoxin." [EC:1.2.7.7]
subset: gosubset_prok
synonym: "2-ketoisovalerate ferredoxin reductase activity" EXACT [EC:1.2.7.7]
synonym: "2-oxoisovalerate ferredoxin reductase activity" EXACT [EC:1.2.7.7]
synonym: "3-methyl-2-oxobutanoate synthase (ferredoxin) activity" EXACT [EC:1.2.7.7]
synonym: "3-methyl-2-oxobutanoate:ferredoxin oxidoreductase (decarboxylating; CoA-2-methylpropanoylating)" EXACT []
synonym: "branched-chain ketoacid ferredoxin reductase activity" RELATED [EC:1.2.7.7]
synonym: "branched-chain oxo acid ferredoxin reductase activity" RELATED [EC:1.2.7.7]
synonym: "keto-valine-ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.7]
synonym: "ketoisovalerate ferredoxin reductase activity" EXACT [EC:1.2.7.7]
synonym: "ketoisovalerate oxidoreductase activity" EXACT [EC:1.2.7.7]
synonym: "VOR" RELATED []
xref: EC:1.2.7.7
xref: MetaCyc:1.2.7.7-RXN
is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0043808
name: lyso-ornithine lipid acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: lyso-ornithine lipid + acyl-[acyl-carrier protein] = ornithine lipid + [acyl-carrier protein]." [IMG:02097, PMID:15341653]
subset: gosubset_prok
is_a: GO:0016410 ! N-acyltransferase activity

[Term]
id: GO:0043810
name: ornithine-acyl [acyl carrier protein] N-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + L-ornithine = lyso-ornithine lipid + [acyl-carrier protein]." [IMG:02096]
subset: gosubset_prok
synonym: "ornithine-acyl[acyl carrier protein] N-acyltransferase activity" EXACT []
is_a: GO:0016410 ! N-acyltransferase activity

[Term]
id: GO:0043811
name: phosphate:acyl-[acyl carrier protein] acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + orthophosphate = acyl phosphate + [acyl-carrier protein]." [IMG:01871]
subset: gosubset_prok
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0043812
name: phosphatidylinositol-4-phosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphatidylinositol-4-phosphate + H2O = phosphatidylinositol + orthophosphate." [IMG:01360]
subset: gosubset_prok
synonym: "phosphatidylinositol 4-phosphate phosphatase activity" EXACT []
xref: EC:3.1.3.-
is_a: GO:0034596 ! phosphatidylinositol phosphate 4-phosphatase activity
is_a: GO:0052744 ! phosphatidylinositol monophosphate phosphatase activity

[Term]
id: GO:0043813
name: phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphatidylinositol-3,5-bisphosphate + H2O = phosphatidylinositol-3-phosphate + orthophosphate." [IMG:01359, PMID:10806194, PMID:16607019]
subset: gosubset_prok
synonym: "phosphatidylinositol 3,5-bisphosphate 5-phosphatase activity" EXACT []
xref: EC:3.1.3.-
is_a: GO:0034593 ! phosphatidylinositol bisphosphate phosphatase activity
is_a: GO:0034595 ! phosphatidylinositol phosphate 5-phosphatase activity
relationship: part_of GO:0036092 ! phosphatidylinositol-3-phosphate biosynthetic process

[Term]
id: GO:0043814
name: phospholactate guanylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-phospho-(S)-lactate + GTP = lactyl-2-diphospho-5'-guanosine + diphosphate." [IMG:01547]
subset: gosubset_prok
xref: EC:2.7.7.-
xref: MetaCyc:RXN-8077
is_a: GO:0070568 ! guanylyltransferase activity

[Term]
id: GO:0043815
name: phosphoribosylglycinamide formyltransferase 2 activity
namespace: molecular_function
def: "Catalysis of the reaction: formate + ATP + 5'-phospho-ribosylglycinamide = 5'-phosphoribosyl-N-formylglycinamide + ADP + diphosphate." [IMG:01297, PMID:8117714]
subset: gosubset_prok
synonym: "5'-phosphoribosylglycinamide transformylase 2" EXACT []
synonym: "formate-dependent GAR transformylase activity" EXACT []
synonym: "GAR transformylase 2" RELATED []
synonym: "GART 2" RELATED []
xref: EC:2.1.2.-
is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity

[Term]
id: GO:0043816
name: phosphoserine-tRNA(Cys) ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: tRNA(Cys) + O-phospho-L-serine + ATP = AMP + diphosphate + phosphoseryl-tRNA(Cys)." [IMG:00622, PMID:17110438]
subset: gosubset_prok
synonym: "O-phosphoseryl-tRNA(Cys) synthetase activity" EXACT []
synonym: "phosphoserine--tRNA(Cys) ligase activity" EXACT []
synonym: "phosphoserine-tRNACys ligase activity" EXACT []
synonym: "SepRS" RELATED []
xref: EC:6.1.1.-
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0043817
name: phosphosulfolactate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2R)-O-phospho-3-sulfolactate = phosphoenolpyruvate + sulfite." [EC:4.4.1.19, RHEA:22787]
subset: gosubset_prok
synonym: "(2R)-O-phospho-3-sulfolactate sulfo-lyase (phosphoenolpyruvate-forming)" EXACT [EC:4.4.1.19]
synonym: "(2R)-O-phospho-3-sulfolactate sulfo-lyase activity" EXACT []
synonym: "(2R)-phospho-3-sulfolactate synthase activity" EXACT [EC:4.4.1.19]
synonym: "PSL synthase activity" EXACT [EC:4.4.1.19]
xref: EC:4.4.1.19
xref: KEGG:R07476
xref: MetaCyc:4.4.1.19-RXN
xref: MetaCyc:R228-RXN
xref: RHEA:22787
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0043818
name: precorrin-3B synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(+) + NADH + O(2) + precorrin-3A = H(2)O + NAD(+) + precorrin-3B." [EC:1.14.13.83, RHEA:17296]
subset: gosubset_prok
synonym: "CobG" RELATED []
synonym: "precorrin-3A,NADH:oxygen oxidoreductase (20-hydroxylating)" EXACT []
synonym: "precorrin-3X synthase activity" EXACT [EC:1.14.13.83]
xref: EC:1.14.13.83
xref: KEGG:R05217
xref: MetaCyc:R321-RXN
xref: RHEA:17296
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0043819
name: precorrin-6A synthase (deacetylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + H(2)O + precorrin-5 = S-adenosyl-L-homocysteine + acetate + 2 H(+) + precorrin-6X." [EC:2.1.1.152, RHEA:18264]
subset: gosubset_prok
synonym: "CobF" RELATED []
synonym: "precorrin-6X synthase (deacetylating) activity" EXACT [EC:2.1.1.152]
synonym: "S-adenosyl-L-methionine:precorrin-5 C1-methyltransferase (deacetylating)" EXACT []
xref: EC:2.1.1.152
xref: KEGG:R05219
xref: MetaCyc:R322-RXN
xref: RHEA:18264
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0043820
name: propionyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the irreversible NADH-dependent formation of propionyl-CoA from acryloyl-CoA." [PMID:12603323]
subset: gosubset_prok
xref: EC:1.3.99.-
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0043821
name: propionyl-CoA:succinate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: succinate + propionyl-CoA = succinyl-CoA + propionate." [IMG:01589, MetaCyc:RXN0-268]
subset: gosubset_prok
synonym: "propionyl-CoA succinate CoA-transferase activity" EXACT []
synonym: "propionyl-CoA:succinate CoA transferase activity" EXACT []
xref: EC:2.8.3.-
xref: MetaCyc:RXN0-268
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0043822
name: ribonuclease M5 activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of RNA, removing 21 and 42 nucleotides, respectively, from the 5'- and 3'-termini of a 5S-rRNA precursor." [EC:3.1.26.8, IMG:02522]
subset: gosubset_prok
synonym: "5S ribosomal maturation nuclease activity" EXACT [EC:3.1.26.8]
synonym: "5S ribosomal RNA maturation endonuclease activity" EXACT []
synonym: "RNase M5 activity" EXACT [EC:3.1.26.8]
xref: EC:3.1.26.8
xref: MetaCyc:3.1.26.8-RXN
is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0043823
name: spheroidene monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: spheroidene + O2 = spheroidenone + H2O." [IMG:01761, MetaCyc:RXN-10670, PMID:16086104, PMID:16158287]
subset: gosubset_prok
xref: EC:1.14.-.-
xref: MetaCyc:RXN-10670
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0043824
name: succinylglutamate-semialdehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-succinyl-L-glutamate 5-semialdehyde + H(2)O + NAD(+) = N-succinyl-L-glutamate + 2 H(+) + NADH." [EC:1.2.1.71, RHEA:10815]
subset: gosubset_prok
synonym: "AruD" RELATED []
synonym: "AstD" RELATED []
synonym: "N-succinyl-L-glutamate 5-semialdehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.71]
synonym: "N-succinylglutamate 5-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.71]
synonym: "SGSD" RELATED []
synonym: "succinyl glutamate-semialdehyde dehydrogenase activity" EXACT []
synonym: "succinylglutamic semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.71]
xref: EC:1.2.1.71
xref: KEGG:R05049
xref: MetaCyc:SUCCGLUALDDEHYD-RXN
xref: RHEA:10815
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0043825
name: succinylornithine transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + N(2)-succinyl-L-ornithine = N-succinyl-L-glutamate 5-semialdehyde + L-glutamate." [EC:2.6.1.81, RHEA:16956]
subset: gosubset_prok
synonym: "2-N-succinyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity" EXACT [EC:2.6.1.81]
synonym: "AstC" RELATED []
synonym: "N(2)-succinylornithine 5-aminotransferase activity" EXACT [EC:2.6.1.81]
synonym: "N2-succinyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity" EXACT []
synonym: "N2-succinylornithine 5-aminotransferase activity" EXACT []
synonym: "SOAT" RELATED []
synonym: "succinyl ornithine transaminase activity" EXACT []
synonym: "succinyl-ornithine transaminase activity" EXACT [EC:2.6.1.81]
synonym: "succinylornithine aminotransferase activity" BROAD [EC:2.6.1.81]
xref: EC:2.6.1.81
xref: KEGG:R04217
xref: MetaCyc:SUCCORNTRANSAM-RXN
xref: RHEA:16956
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0043826
name: sulfur oxygenase reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5 sulfur + oxygen + 4 H2O = sulfite + thiosulfate + 2 hydrogen sulfide + 9 H+." [IMG:00713, MetaCyc:RXN-8226, PMID:1522063]
subset: gosubset_prok
synonym: "SOR" RELATED []
synonym: "sulphur oxygenase reductase activity" EXACT []
xref: EC:1.-.-.-
xref: MetaCyc:RXN-8226
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0043827
name: tRNA (adenine-57, 58-N(1)-) methyltransferase activity
namespace: molecular_function
def: "Catalysis of the methylation of adenine-57 and adenine-58 in the T-loop of tRNA." [IMG:00706, PMID:14739239]
subset: gosubset_prok
synonym: "TrmI" RELATED []
synonym: "tRNA (adenine-57, 58 N1-) methyltransferase activity" EXACT []
synonym: "tRNA (adenine-57, 58-N1-) methyltransferase activity" EXACT []
synonym: "tRNA (m1A) MTase" BROAD []
xref: EC:2.1.1.-
is_a: GO:0016429 ! tRNA (adenine-N1-)-methyltransferase activity

[Term]
id: GO:0043828
name: tRNA 2-selenouridine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-methylaminomethyl-2-thiouridine + selenophosphate = 5-methylaminomethyl-2-selenouridine + phosphate (at the wobble position in tRNA)." [IMG:02609, MetaCyc:RXN0-2281]
subset: gosubset_prok
synonym: "B0503" RELATED []
synonym: "SelU" RELATED []
synonym: "YbbB" RELATED []
xref: EC:2.9.1.-
xref: MetaCyc:RXN0-2281
is_a: GO:0016785 ! transferase activity, transferring selenium-containing groups

[Term]
id: GO:0043829
name: tRNA-specific adenosine-37 deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: adenosine-37 + H2O = inosine-37 + NH3, in a tRNA-Ala molecule." [IMG:00703, PMID:8915538, PMID:9707437]
subset: gosubset_prok
synonym: "TAD1" RELATED []
synonym: "tRNA(Ala)-A37 deaminase activity" EXACT []
synonym: "tRNA-specific adenosine deaminase 1" EXACT []
xref: EC:3.5.4.-
is_a: GO:0008251 ! tRNA-specific adenosine deaminase activity

[Term]
id: GO:0043830
name: thiol-driven fumarate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: fumarate + coenzyme M + coenzyme B = succinate + coenzyme M + coenzyme B + heterodisulfide." [IMG:01366, PMID:2509466]
subset: gosubset_prok
xref: EC:1.3.99.-
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0043831
name: thiosulfate dehydrogenase (quinone) activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-decylubiquinone + 2 thiosulfate = 6-decylubiquinol + tetrathionate." [EC:1.8.5.2, RHEA:10939]
subset: gosubset_prok
synonym: "DoxA" RELATED []
synonym: "DoxD" RELATED []
synonym: "thiosulfate oxidoreductase, tetrathionate-forming activity" EXACT [EC:1.8.5.2]
synonym: "thiosulfate:6-decylubiquinone oxidoreductase activity" EXACT [EC:1.8.5.2]
synonym: "thiosulfate:quinone oxidoreductase activity" EXACT [EC:1.8.5.2]
synonym: "thiosulphate dehydrogenase (quinone) activity" EXACT []
synonym: "thiosulphate:quinone oxidoreductase activity" EXACT []
synonym: "TQO" RELATED []
xref: EC:1.8.5.2
xref: KEGG:R07177
xref: MetaCyc:1.8.5.2-RXN
xref: RHEA:10939
is_a: GO:0016672 ! oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor

[Term]
id: GO:0043833
name: methylamine-specific methylcobalamin:coenzyme M methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a methylated methylamine corrinoid protein + coenzyme M = a methylamine corrinoid protein + methyl-CoM. This reaction is the transfer of the methyl group from the methylated corrinoid cofactor of a methylamine corrinoid protein to coenzyme M." [IMG:01318, MetaCyc:RXN-8099]
comment: This function is the second step in the pathway of methanogenesis from monomethylamine, dimethylamine and trimethylamine.
subset: gosubset_prok
synonym: "dimethylamine-specific methylcobalamin:coenzyme M methyltransferase activity" NARROW []
synonym: "methylamine-specific methylcobalamin:CoM methyltransferase activity" EXACT []
synonym: "methylcobamide:coenzyme M methyltransferase activity" EXACT []
synonym: "methylcobamide:CoM methyltransferase activity" EXACT []
synonym: "methylcobamide:CoM methyltransferase II isozyme A" RELATED []
synonym: "monomethylamine-specific methylcobalamin:coenzyme M methyltransferase activity" NARROW []
synonym: "MT2" BROAD []
synonym: "MT2-A" RELATED []
synonym: "MtbA" RELATED []
synonym: "trimethylamine-specific methylcobalamin:coenzyme M methyltransferase activity" NARROW []
xref: EC:2.1.1.-
xref: MetaCyc:RXN-8099
xref: MetaCyc:RXN-8101
xref: MetaCyc:RXN-8103
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0043834
name: trimethylamine methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: trimethylamine + a trimethylamine corrinoid protein = a methylated trimethylamine corrinoid protein + dimethylamine." [IMG:01323, MetaCyc:RXN-8102]
comment: This function is the first step in the pathway of methanogenesis from trimethylamine.
subset: gosubset_prok
synonym: "MT1" BROAD []
synonym: "mttB1" RELATED []
synonym: "TMA methyltransferase 1" EXACT []
synonym: "trimethylamine:corrinoid methyltransferase activity" EXACT []
xref: EC:2.1.1.-
xref: MetaCyc:RXN-8102
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0043835
name: obsolete uracil/thymine dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reactions: uracil + H2O + acceptor = barbiturate + reduced acceptor; and thymine + H2O + acceptor = 5-methylbarbiturate + reduced acceptor." [EC:1.17.99.4, IMG:01821]
comment: This term was made obsolete because it represents two separate molecular functions.
synonym: "uracil oxidase activity" RELATED [EC:1.17.99.4]
synonym: "uracil-thymine oxidase activity" EXACT [EC:1.17.99.4]
synonym: "uracil/thymine dehydrogenase activity" EXACT []
synonym: "uracil:acceptor oxidoreductase activity" NARROW []
xref: EC:1.17.99.4
is_obsolete: true
consider: GO:0050383
consider: GO:0052620

[Term]
id: GO:0043836
name: xanthine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: xanthine + H2O = 4-ureido-5-imidazole carboxylate." [IMG:01834, MetaCyc:R127-RXN]
subset: gosubset_prok
synonym: "xanthinase activity" EXACT []
xref: EC:3.5.2.-
xref: MetaCyc:R127-RXN
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0043837
name: valine dehydrogenase (NAD) activity
namespace: molecular_function
def: "Catalysis of the reaction: L-valine + H2O + NAD+ = 3-methyl-2-oxobutanoate + NH3 + NADH." [IMG:00766, PMID:10612726, PMID:2803248]
subset: gosubset_prok
synonym: "ValDH" RELATED []
xref: EC:1.4.1.-
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

[Term]
id: GO:0043838
name: phosphatidylethanolamine:Kdo2-lipid A phosphoethanolamine transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: Kdo2-lipid A + phosphatidylethanolamine = phosphoethanolamine-Kdo2-lipid A + diacylglycerol." [IMG:00182, PMID:15795227]
comment: Note that Kdo is an abbreviation for 3-deoxy-D-manno-oct-2-ulosonic acid.
subset: gosubset_prok
synonym: "EptB" RELATED []
synonym: "phosphoethanolamine transferase" BROAD []
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0043839
name: lipid A phosphate methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosylmethionine (SAM) to the 1-phosphate group of lipid A." [IMG:02094, PMID:15994324]
subset: gosubset_prok
synonym: "lipid A 1-phosphomethyltransferase activity" EXACT []
synonym: "lipid A methyltransferase" BROAD []
synonym: "lipid A phosphomethyltransferase activity" EXACT []
synonym: "LmtA" RELATED []
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0043840
name: branched-chain amino acid:2-keto-4-methylthiobutyrate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-keto-4-methylthiobutyrate + L-phenylalanine = phenylpyruvate + L-methionine." [IMG:01684, PMID:12670965]
subset: gosubset_prok
synonym: "BCAT" RELATED []
synonym: "branched chain amino acid:2-keto-4-methylthiobutyrate aminotransferase activity" EXACT []
synonym: "branched-chain amino acid aminotransferase" BROAD []
synonym: "branched-chain-amino-acid:2-keto-4-methylthiobutyrate aminotransferase activity" EXACT []
xref: EC:2.6.1.-
xref: MetaCyc:RXN-7708
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0043841
name: (S)-lactate 2-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-lactate + GTP = 2-phospho-(S)-lactate + GDP." [IMG:01546, PMID:11535063]
subset: gosubset_prok
synonym: "lactate 2-kinase activity" EXACT []
xref: EC:2.7.1.-
xref: IMG:01546
xref: MetaCyc:RXN-8076
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0043842
name: Kdo transferase activity
namespace: molecular_function
def: "Catalysis of the reactions: (KDO)-lipid IVA + CMP-3-deoxy-D-manno-octulosonate = KDO2-lipid IVA + CMP, and lipid IVA + CMP-3-deoxy-D-manno-octulosonate = (KDO)-lipid IVA + CMP." [IMG:00549, PMID:1577828, PMID:2033061, PMID:9195966]
subset: gosubset_prok
synonym: "3-deoxy-D-manno-octulosonic-acid transferase activity" EXACT []
synonym: "kdtA" RELATED []
synonym: "WaaA" RELATED []
xref: EC:2.-.-.-
xref: MetaCyc:KDOTRANS-RXN
xref: MetaCyc:KDOTRANS2-RXN
is_a: GO:0016740 ! transferase activity

[Term]
id: GO:0043843
name: ADP-specific glucokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ADP + D-glucose = AMP + D-glucose 6-phosphate." [EC:2.7.1.147, IMG:01468]
subset: gosubset_prok
synonym: "ADP-dependent glucokinase activity" EXACT [EC:2.7.1.147]
synonym: "ADP:D-glucose 6-phosphotransferase activity" EXACT [EC:2.7.1.147]
xref: EC:2.7.1.147
xref: RHEA:11463
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0043844
name: ADP-specific phosphofructokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ADP + D-fructose 6-phosphate = AMP + D-fructose 1,6-bisphosphate." [EC:2.7.1.146, IMG:01469]
subset: gosubset_prok
synonym: "ADP-6-phosphofructokinase activity" EXACT [EC:2.7.1.146]
synonym: "ADP-dependent phosphofructokinase activity" EXACT [EC:2.7.1.146]
synonym: "ADP-Pfk activity" EXACT [EC:2.7.1.146]
synonym: "ADP:D-fructose-6-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.146]
xref: EC:2.7.1.146
xref: RHEA:20108
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0043845
name: DNA polymerase III, proofreading complex
namespace: cellular_component
def: "A subcomplex of DNA polymerase III composed of the epsilon subunit which has proofreading activity, and the theta subunit which enhances the epsilon subunit's proofreading activity." [IMG:01721, PMID:16973612, Wikipedia:Pol_III]
subset: gosubset_prok
synonym: "DNA polymerase III, proof-reading complex" EXACT []
synonym: "DNA polymerase III, proof-reading subcomplex" EXACT []
synonym: "DNA polymerase III, proofreading subcomplex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0044776 ! DNA polymerase III, core complex

[Term]
id: GO:0043846
name: DNA polymerase III, clamp loader complex
namespace: cellular_component
def: "A heptamer that includes the tau and gamma products of the dnaX gene and the chi/psi subcomplex. Confers structural asymmetry that allows the polymerase to replicate both leading and lagging strands." [PMID:12940977]
subset: gosubset_prok
synonym: "clamp loader complex" BROAD []
synonym: "DNA polymerase III, DnaX complex" EXACT []
synonym: "DNA polymerase III, DnaX subcomplex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0009360 ! DNA polymerase III complex

[Term]
id: GO:0043847
name: DNA polymerase III, clamp loader chi/psi subcomplex
namespace: cellular_component
def: "A dimer composed of the chi and psi subunits which is a subassembly of the DNA polymerase III clamp loader complex and serves as a bridge between the DnaX complex and the single-stranded DNA-binding protein (SSB)." [IMG:01719, PMID:12940977]
subset: gosubset_prok
synonym: "DNA polymerase III, DnaX complex, chi/psi subcomplex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0043846 ! DNA polymerase III, clamp loader complex

[Term]
id: GO:0043848
name: excinuclease cho activity
namespace: molecular_function
def: "Catalysis of the incision of damaged DNA on the 3' side of a lesion, typically at the ninth phosphodiester bond 3' of the damage." [IMG:00499, PMID:11818552]
comment: Note that this function occurs as part of nucleotide excision repair (NER).
subset: gosubset_prok
synonym: "cho" RELATED []
synonym: "endonuclease cho" EXACT []
synonym: "uvrc homolog protein" RELATED []
is_a: GO:0016890 ! site-specific endodeoxyribonuclease activity, specific for altered base

[Term]
id: GO:0043849
name: Ras palmitoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA, specific for Ras proteins." [IMG:00473, PMID:16000296]
subset: gosubset_prok
synonym: "DHHC cysteine-rich domain-containing protein ERF2" RELATED []
synonym: "ERF2" RELATED []
synonym: "palmitoyltransferase ERF2" RELATED []
synonym: "Ras protein acyltransferase activity" EXACT []
xref: EC:2.3.1.-
is_a: GO:0016409 ! palmitoyltransferase activity

[Term]
id: GO:0043850
name: RecFOR complex
namespace: cellular_component
def: "A heterotrimeric complex composed of the subunits RecF, RecO and RecR. Mediates the loading of RecA protein specifically onto SSB-coated gapped DNA during DNA repair." [IMG:01764, PMID:12769856]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part

[Term]
id: GO:0043851
name: methanol-specific methylcobalamin:coenzyme M methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a methylated methanol corrinoid protein + coenzyme M = a methanol corrinoid protein + methyl-CoM. This reaction is the transfer of the methyl group from the methylated corrinoid cofactor of a methylamine corrinoid protein to coenzyme M." [IMG:01315, MetaCyc:RXN-8096]
comment: This function is the second step in the pathway of methanogenesis from methanol.
subset: gosubset_prok
synonym: "methanol-specific methylcobalamin: coenzyme M methyltransferase activity" EXACT []
synonym: "methanol-specific methylcobalamin:CoM methyltransferase activity" EXACT []
synonym: "methyltransferase 2" BROAD []
synonym: "MT2" BROAD []
synonym: "MtaA" RELATED []
synonym: "MtaC protein: coenzyme M methyltransferase activity" EXACT []
synonym: "MtaC protein:coenzyme M methyltransferase activity" EXACT []
xref: EC:2.1.1.-
xref: MetaCyc:RXN-8096
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0043852
name: monomethylamine methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: monomethylamine + a monomethylamine corrinoid protein = a methylated monomethylamine corrinoid protein + NH3." [IMG:01319, MetaCyc:RXN-8098]
comment: This function is the first step in the pathway of methanogenesis from monomethylamine.
subset: gosubset_prok
synonym: "MMAMT" RELATED []
synonym: "monomethylamine:corrinoid methyltransferase activity" EXACT []
synonym: "MtmB" RELATED []
xref: EC:2.1.1.-
xref: MetaCyc:RXN-8098
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0043853
name: methanol-CoM methyltransferase complex
namespace: cellular_component
def: "A heterotrimeric protein complex composed of a methanol methyltransferase subunit, a corrinoid protein and a methanol-specific corrinoid:coenzyme M methyltransferase subunit. Catalyzes the transfer of a methyl group from methanol to coenzyme M as part of the pathway of methanogenesis from methanol." [IMG:01437, MetaCyc:CPLX-421, PMID:9363780]
subset: gosubset_prok
synonym: "methanol-coenzyme M methyltransferase complex" EXACT []
synonym: "methanol: coenzyme M methyltransferase complex" EXACT []
synonym: "methanol: CoM methyltransferase complex" EXACT []
synonym: "methanol:coenzyme M methyltransferase complex" EXACT []
synonym: "methanol:CoM methyltransferase complex" EXACT []
xref: MetaCyc:CPLX-421
is_a: GO:0034708 ! methyltransferase complex

[Term]
id: GO:0043854
name: cyclic nucleotide-gated mechanosensitive ion channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of an ion by a channel that opens in response to a mechanical stress and when a cyclic nucleotide has been bound by the channel complex or one of its constituent parts." [GOC:jl, IMG:02416]
subset: gosubset_prok
synonym: "cyclic nucleotide gated mechanosensitive ion channel activity" EXACT []
synonym: "cyclic nucleotide regulated mechanosensitive ion channel" EXACT []
synonym: "cyclic nucleotide-regulated mechanosensitive ion channel" EXACT []
synonym: "cyclic nucleotide-regulated small mechanosensitive ion channel" RELATED []
synonym: "MscS" RELATED []
synonym: "small conductance mechanosensitive ion channel" EXACT []
is_a: GO:0008381 ! mechanically-gated ion channel activity
is_a: GO:0043855 ! cyclic nucleotide-gated ion channel activity

[Term]
id: GO:0043855
name: cyclic nucleotide-gated ion channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of an ion by a channel that opens when a cyclic nucleotide has been bound by the channel complex or one of its constituent parts." [GOC:jl]
subset: gosubset_prok
synonym: "cyclic nucleotide activated ion channel activity" EXACT []
synonym: "cyclic nucleotide gated ion channel activity" EXACT []
synonym: "cyclic nucleotide-activated ion channel activity" EXACT []
is_a: GO:0015276 ! ligand-gated ion channel activity

[Term]
id: GO:0043856
name: anti-sigma factor antagonist activity
namespace: molecular_function
def: "The function of binding to an anti-sigma factor and stopping, preventing or reducing the rate of its activity." [GOC:jl, GOC:txnOH, PMID:15576799]
subset: gosubset_prok
synonym: "anti-anti-sigma factor activity" EXACT []
is_a: GO:0000989 ! transcription factor activity, transcription factor binding
relationship: part_of GO:0045893 ! positive regulation of transcription, DNA-templated

[Term]
id: GO:0043857
name: N-acetylornithine carbamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N(2)-acetyl-L-ornithine + carbamoyl phosphate = N(2)-acetyl-L-citrulline + H(+) + phosphate." [EC:2.1.3.9, RHEA:18612]
subset: gosubset_prok
synonym: "acetylornithine transcarbamylase activity" EXACT []
synonym: "AOTC" RELATED []
synonym: "carbamoyl-phosphate:2-N-acetyl-L-ornithine carbamoyltransferase activity" EXACT [EC:2.1.3.9]
synonym: "carbamoyl-phosphate:N2-acetyl-L-ornithine carbamoyltransferase activity" EXACT [EC:2.1.3.9]
synonym: "N-acetylornithine transcarbamylase activity" EXACT []
xref: EC:2.1.3.9
xref: KEGG:R07245
xref: MetaCyc:2.1.3.9-RXN
xref: RHEA:18612
is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity

[Term]
id: GO:0043858
name: arginine:ornithine antiporter activity
namespace: molecular_function
def: "Catalysis of the reaction: arginine(out) + ornithine(in) = arginine(in) + ornithine(out)." [GOC:jl, PMID:17110979]
subset: gosubset_prok
synonym: "ArcD" RELATED []
synonym: "arginine-ornithine antiporter activity" EXACT []
synonym: "arginine/ornithine antiporter activity" EXACT []
is_a: GO:0015181 ! arginine transmembrane transporter activity
is_a: GO:0015301 ! anion:anion antiporter activity
is_a: GO:0015491 ! cation:cation antiporter activity

[Term]
id: GO:0043859
name: obsolete cyanophycinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolytic cleavage of multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer) into aspartate-arginine dipeptides." [PMID:10429200]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "cyanophycinase activity" EXACT []
xref: EC:3.-.-.-
is_obsolete: true
replaced_by: GO:0008236

[Term]
id: GO:0043860
name: cyanophycin synthetase activity
namespace: molecular_function
def: "Catalysis of the ATP-dependent polymerization of arginine and aspartate to multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer)." [EC:6.3.2.29, EC:6.3.2.30, GOC:jl]
subset: gosubset_prok
synonym: "cphA" RELATED []
xref: EC:6.3.1.-
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0043861
name: agmatine:putrescine antiporter activity
namespace: molecular_function
def: "Catalysis of the reaction: agmatine(out) + putrescine(in) = agmatine(in) + putrescine(out)." [GOC:jl, PMID:17028272]
subset: gosubset_prok
synonym: "agmatine-putrescine antiporter activity" EXACT []
synonym: "agmatine/putrescine antiporter activity" EXACT []
is_a: GO:0015489 ! putrescine transmembrane transporter activity
is_a: GO:0015491 ! cation:cation antiporter activity

[Term]
id: GO:0043862
name: arginine:agmatine antiporter activity
namespace: molecular_function
def: "Catalysis of the reaction: arginine(out) + agmatine(in) = arginine(in) + agmatine(out)." [GOC:jl, PMID:17099215]
subset: gosubset_prok
synonym: "AdiC" RELATED []
synonym: "arginine-agmatine antiporter activity" EXACT []
synonym: "arginine-agmatine exchange transporter activity" EXACT []
synonym: "arginine/agmatine antiporter activity" EXACT []
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:0015181 ! arginine transmembrane transporter activity
is_a: GO:0015491 ! cation:cation antiporter activity

[Term]
id: GO:0043863
name: 4-hydroxy-2-ketopimelate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxy-2-ketopimelate = succinate semialdehyde + pyruvate." [MetaCyc:4-HYDROXY-2-KETOPIMELATE-LYSIS-RXN]
subset: gosubset_prok
synonym: "2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase activity" EXACT []
synonym: "HHED aldolase activity" EXACT []
synonym: "HpaI" RELATED []
synonym: "HpcH" RELATED []
xref: EC:4.1.2.-
xref: MetaCyc:4-HYDROXY-2-KETOPIMELATE-LYSIS-RXN
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0043864
name: indoleacetamide hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: indole-3-acetamide + H2O = indole-3-acetate + NH3. Indole-3-acetamide is known as IAM and indole-3-acetate as IAA." [GOC:jl, MetaCyc:RXNN-404]
subset: gosubset_prok
synonym: "IaaH" RELATED []
synonym: "IAH" EXACT []
synonym: "indole acetamide hydrolase activity" EXACT []
synonym: "indole-3-acetamide hydrolase activity" EXACT []
synonym: "Tms2" RELATED []
xref: EC:3.5.1.-
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0043865
name: methionine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of methionine from one side of a membrane to the other." [GOC:jl]
subset: gosubset_prok
is_a: GO:0000099 ! sulfur amino acid transmembrane transporter activity
is_a: GO:0008324 ! cation transmembrane transporter activity
relationship: part_of GO:0015821 ! methionine transport

[Term]
id: GO:0043866
name: adenylyl-sulfate reductase (thioredoxin) activity
namespace: molecular_function
def: "Catalysis of the reaction: AMP + sulfite + thioredoxin disulfide = 5'-adenylyl sulfate + thioredoxin." [EC:1.8.4.10]
subset: gosubset_prok
synonym: "AMP, sulfite:thioredoxin-disulfide oxidoreductase (adenosine-5'-phosphosulfate-forming)" EXACT []
synonym: "AMP,sulfite:thioredoxin-disulfide oxidoreductase (adenosine-5'-phosphosulfate-forming)" EXACT [EC:1.8.4.10]
synonym: "thioredoxin-dependent 5'-adenylylsulfate reductase activity" EXACT []
xref: EC:1.8.4.10
xref: RHEA:21979
is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor

[Term]
id: GO:0043867
name: 7-cyano-7-deazaguanine tRNA-ribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: tRNA guanine + 7-cyano-7-deazaguanine = tRNA 7-cyano-7-deazaguanine + guanine." [PMID:16407303, PMID:7748953]
subset: gosubset_prok
synonym: "archaeal tRNA-guanine transglycosylase activity" EXACT []
synonym: "archaeosine tRNA-ribosyltransferase activity" EXACT []
synonym: "TgtA" RELATED []
xref: EC:2.4.2.-
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0043869
name: alpha-aminoadipate acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-aminoadipate + acetyl-CoA = N2-acetyl-alpha-aminoadipate + coenzyme A." [MetaCyc:RXN-5181, PMID:10613839, PMID:12925802]
subset: gosubset_prok
synonym: "lysine biosynthesis protein" RELATED []
synonym: "LysX" RELATED []
synonym: "RimK" RELATED []
xref: MetaCyc:RXN-5181
is_a: GO:0016407 ! acetyltransferase activity

[Term]
id: GO:0043870
name: N-acetyl-gamma-aminoadipyl-phosphate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: N(2)-acetyl-L-aminoadipate-semialdehyde + NADP+ + phosphate = N(2)-acetyl-L-gamma-aminoadipyl phosphate + NADPH." [MetaCyc:RXN-5183]
comment: This function is part of the prokaryotic alpha-aminoadipate lysine biosynthesis pathway.
subset: gosubset_prok
synonym: "AGPR" RELATED []
synonym: "ArgC" RELATED []
synonym: "LysY" RELATED []
synonym: "N-acetyl-alpha-glutamyl-phosphate reductase activity" EXACT []
synonym: "N-acetyl-aminoadipate semialdehyde dehydrogenase activity" EXACT []
synonym: "NAGSA dehydrogenase activity" BROAD []
xref: EC:1.2.1.-
xref: MetaCyc:RXN-5183
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0043871
name: delta1-piperideine-6-carboxylate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: delta1-piperideine-6-carboxylate + NAD+ + 2 H2O = 2-aminoadipate + NADH + H+. Delta1-piperideine-6-carboxylate is also known as 2,3,4,5-tetrahydropyridine-2-carboxylate." [MetaCyc:RXN-8162, PMID:16237033]
comment: This function is part of the pipecolate pathway of lysine catabolism.
subset: gosubset_prok
synonym: "AmaB" RELATED []
synonym: "PIPOX" RELATED []
xref: MetaCyc:RXN-8162
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0043872
name: lysine:cadaverine antiporter activity
namespace: molecular_function
alt_id: GO:0015497
def: "Catalysis of the reaction: lysine(out) + cadaverine(in) = lysine(in) + cadaverine(out)." [GOC:jl, PMID:10986235, TC:2.A.3.2.2]
subset: gosubset_prok
synonym: "cadaverine:lysine antiporter activity" EXACT []
synonym: "CadB" RELATED []
synonym: "lysine-cadaverine antiporter activity" EXACT []
synonym: "lysine/cadaverine antiporter activity" EXACT []
is_a: GO:0015189 ! L-lysine transmembrane transporter activity
is_a: GO:0015490 ! cadaverine transmembrane transporter activity
is_a: GO:0015491 ! cation:cation antiporter activity

[Term]
id: GO:0043873
name: pyruvate-flavodoxin oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyruvate + CoA + oxidized flavodoxin = acetyl-CoA + CO2 + reduced flavodoxin." [PMID:6352705]
subset: gosubset_prok
synonym: "NifJ" RELATED []
synonym: "pyruvate:flavodoxin oxidoreductase activity" EXACT []
xref: EC:1.2.7.-
xref: MetaCyc:PYFLAVOXRE-RXN
is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0043874
name: acireductone synthase activity
namespace: molecular_function
def: "Catalysis of the reactions: 5-(methylthio)-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate; (1a) 5-(methylthio)-2,3-dioxopentyl phosphate = 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate; (1b) 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate." [EC:3.1.3.77]
comment: This function is involved in the process of methionine salvage.
subset: gosubset_prok
synonym: "5-(methylthio)-2,3-dioxopentyl-phosphate phosphohydrolase (isomerizing)" EXACT [EC:3.1.3.77]
synonym: "E-1" RELATED []
synonym: "E-1 enolase-phosphatase" BROAD []
xref: EC:3.1.3.77
xref: MetaCyc:3.1.3.77-RXN
xref: Reactome:REACT_75868 "Acireductone is created, Homo sapiens"
xref: RHEA:24650
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0043875
name: 2-ketobutyrate formate-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxobutanoate + coenzyme A = propionyl-CoA + formate." [MetaCyc:KETOBUTFORMLY-RXN, PMID:9484901]
comment: This function is part of an anaerobic pathway for the catabolism of L-threonine.
subset: gosubset_prok
synonym: "keto-acid formate acetyltransferase" BROAD []
synonym: "KFL" EXACT []
synonym: "TdcE" RELATED []
xref: EC:2.3.1-
xref: MetaCyc:KETOBUTFORMLY-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0043876
name: D-threonine aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-threonine (or D-allo-threonine) = glycine + acetaldehyde." [MetaCyc:4.1.2.42-RXN, PMID:9642221]
subset: gosubset_prok
synonym: "D-allo-TA" EXACT []
synonym: "D-allo-threonine aldolase activity" EXACT []
synonym: "D-TA" EXACT []
synonym: "DtaAS" RELATED []
synonym: "low-specificity D-threonine aldolase" NARROW []
xref: EC:4.1.2.-
xref: MetaCyc:4.1.2.42-RXN
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0043877
name: galactosamine-6-phosphate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-galactosamine 6-phosphate + H2O = D-tagatose 6-phosphate + NH3." [PMID:10931310]
comment: This function is part of the pathway of N-acetyl-galactosamine and galactosamine utilization.
subset: gosubset_prok
synonym: "AgaI" RELATED []
synonym: "galactosamine-6-phosphate deaminase activity" EXACT []
xref: EC:5.3.1.-
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0043878
name: glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + NAD+ + H2O = 3-phospho-D-glycerate + NADH + H+." [PMID:9497334]
subset: gosubset_prok
synonym: "glyceraldehyde-3-phosphate dehydrogenase (NAD) (non-phosphorylating) activity" EXACT []
synonym: "glyceraldehyde-3-phosphate dehydrogenase (NAD) activity" EXACT []
synonym: "NAD+-dependent glyceraldehyde-3-phosphate dehydrogenase activity" EXACT []
synonym: "non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (NAD)" EXACT []
xref: EC:1.2.1.-
xref: MetaCyc:RXN-3443
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0043879
name: glycolate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of glycolate from one side of a membrane to the other. Glycolate is the smallest alpha-hydroxy acid (AHA)." [CHEBI:28905, GOC:jl]
subset: gosubset_prok
synonym: "glcA" RELATED []
synonym: "glycolate permease" RELATED []
synonym: "glycolic acid transmembrane transporter activity" EXACT []
synonym: "hydroxyacetic acid transmembrane transporter activity" EXACT []
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:0015665 ! alcohol transmembrane transporter activity
relationship: part_of GO:0097339 ! glycolate transmembrane transport

[Term]
id: GO:0043880
name: crotonyl-CoA reductase activity
namespace: molecular_function
def: "Catalysis of the reduction of crotonyl-CoA to butyryl-CoA." [InterPro:IPR010085, PMID:11162231]
subset: gosubset_prok
synonym: "CCR" EXACT []
synonym: "crotonyl-coenzyme A reductase activity" EXACT []
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0043881
name: mesaconyl-CoA hydratase activity
namespace: molecular_function
def: "Catalysis of the hydration of mesaconyl-CoA to beta-methylmalyl-CoA." [PMID:16856935, PMID:16856937]
comment: This function is part of an alternate glyoxylate cycle for acetate assimilation.
subset: gosubset_prok
synonym: "beta-methylmalyl-CoA dehydratase activity" EXACT []
synonym: "mch" RELATED []
synonym: "mesaconyl-coenzyme A hydratase activity" EXACT []
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0043882
name: malate:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: malate(out) + Na+(out) = malate(in) + Na+(in)." [GOC:jl, PMID:10903309]
subset: gosubset_prok
synonym: "malate Na(+) symporter activity" EXACT []
synonym: "malate-sodium symporter activity" EXACT []
synonym: "malate/sodium cotransporter activity" BROAD []
synonym: "malate/sodium symporter activity" EXACT []
synonym: "malate:Na+ symporter activity" EXACT []
synonym: "malate:sodium cotransporter activity" BROAD []
synonym: "Na(+)-malate symporter activity" EXACT []
synonym: "Na+:malate symporter activity" EXACT []
synonym: "sodium-dependent malate transporter" BROAD []
synonym: "sodium/malate symporter activity" EXACT []
synonym: "sodium:malate symporter activity" EXACT []
is_a: GO:0005343 ! organic acid:sodium symporter activity
is_a: GO:0015140 ! malate transmembrane transporter activity
is_a: GO:0015296 ! anion:cation symporter activity

[Term]
id: GO:0043883
name: malolactic enzyme activity
namespace: molecular_function
def: "Catalysis of the reaction: malate + H+ = L-lactate + CO2." [MetaCyc:RXN8E-5623, PMID:3139053]
comment: This function is part of the process of degradation of L-malic acid by lactic acid bacteria.
subset: gosubset_prok
synonym: "MleS" RELATED []
xref: EC:1.-.-.-
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0043884
name: CO-methylating acetyl-CoA synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + corrinoid protein = CO + methylcorrinoid protein + CoA." [EC:2.3.1.169, PMID:1748656]
subset: gosubset_prok
synonym: "acetyl-CoA synthase activity" BROAD []
synonym: "acetyl-CoA:corrinoid protein O-acetyltransferase activity" EXACT []
synonym: "ACS" RELATED [EC:2.3.1.169]
synonym: "CO-methylating acetyl-coenzyme A synthase activity" EXACT []
xref: EC:2.3.1.169
xref: MetaCyc:ACETYLSYNCLTH-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0043885
name: carbon-monoxide dehydrogenase (ferredoxin) activity
namespace: molecular_function
def: "Catalysis of the reaction: CO + H2O + oxidized ferredoxin = CO2 + reduced ferredoxin." [EC:1.2.7.4]
subset: gosubset_prok
synonym: "carbon monoxide dehydrogenase (ferredoxin) activity" EXACT []
synonym: "carbon monoxide dehydrogenase activity" BROAD []
synonym: "carbon-monoxide dehydrogenase activity" BROAD [EC:1.2.7.4]
synonym: "carbon-monoxide,water:ferredoxin oxidoreductase activity" EXACT []
synonym: "carbon-monoxide:(acceptor) oxidoreductase activity" EXACT []
synonym: "CO dehydrogenase activity" EXACT []
synonym: "CO-dehydrogenase (ferredoxin) activity" EXACT []
synonym: "CO-dehydrogenase activity" EXACT []
synonym: "CODH" RELATED []
xref: EC:1.2.7.4
xref: MetaCyc:CARBON-MONOXIDE-DEHYDROGENASE-RXN
is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0043886
name: structural constituent of carboxysome
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of a carboxysome, an organelle found in the Cyanobacteria consisting of a proteinaceous coat and enzymes for the fixation of carbon dioxide." [GOC:jl]
subset: gosubset_prok
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0043887
name: melibiose:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: melibiose(out) + Na+(out) = melibiose(in) + Na+(in)." [PMID:1970646]
subset: gosubset_prok
synonym: "MelB" RELATED []
synonym: "melibiose carrier protein" RELATED []
synonym: "melibiose permease" BROAD []
synonym: "melibiose-Na+ symporter activity" EXACT []
synonym: "melibiose-sodium symporter activity" EXACT []
synonym: "melibiose/Na+ symporter activity" EXACT []
synonym: "melibiose/sodium symporter activity" EXACT []
synonym: "melibiose:Na+ symporter activity" EXACT []
synonym: "Na+ (Li+)/melibiose symporter activity" EXACT []
synonym: "Na+-melibiose symporter activity" EXACT []
synonym: "Na+/melibiose symporter activity" EXACT []
synonym: "Na+:melibiose symporter activity" EXACT []
synonym: "sodium-melibiose symporter activity" EXACT []
synonym: "sodium/melibiose symporter activity" EXACT []
synonym: "sodium:melibiose symporter activity" EXACT []
synonym: "thiomethylgalactoside permease II" RELATED []
is_a: GO:0015081 ! sodium ion transmembrane transporter activity
is_a: GO:0015487 ! melibiose:monovalent cation symporter activity

[Term]
id: GO:0043888
name: (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase activity
namespace: molecular_function
def: "Catalysis of the transfer of a geranylgeranyl group from geranylgeranyl diphosphate to (S)-3-O-geranylgeranylglyceryl phosphate to form (S)-2,3-di-O-geranylgeranylglyceryl phosphate." [PMID:15356000, PMID:16494480]
comment: This function is involved in archaeal lipid synthesis.
subset: gosubset_prok
synonym: "2,3-dGGGPS" EXACT []
synonym: "DGGGP synthase activity" EXACT []
synonym: "DGGGPS" EXACT []
synonym: "UbiA" RELATED []
xref: EC:2.5.1.-
is_a: GO:0002094 ! polyprenyltransferase activity
is_a: GO:0004337 ! geranyltranstransferase activity

[Term]
id: GO:0043889
name: (S)-3-O-geranylgeranylglyceryl phosphate synthase activity
namespace: molecular_function
def: "Catalysis of the alkylation of the primary hydroxyl group in (S)-glyceryl phosphate by geranylgeranyl diphosphate to form (S)-3-O-geranylgeranylglyceryl phosphate." [PMID:12801917, PMID:17253090, PMID:8408023]
comment: This function is involved in archaeal lipid synthesis.
subset: gosubset_prok
synonym: "(S)-3-O-geranylgeranylglycerylphosphate synthase activity" EXACT []
synonym: "(S)-GGGP synthase activity" EXACT []
synonym: "GGGP synthase activity" EXACT []
synonym: "GGGPS" EXACT []
is_a: GO:0004659 ! prenyltransferase activity

[Term]
id: GO:0043890
name: N-acetylgalactosamine-6-sulfatase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate." [EC:3.1.6.4]
subset: gosubset_prok
synonym: "acetylgalactosamine 6-sulfatase activity" EXACT []
synonym: "chondroitin sulfatase" BROAD []
synonym: "chondroitinase" BROAD []
synonym: "chondroitinsulfatase" BROAD [EC:3.1.6.4]
synonym: "galactose-6-sulfate sulfatase activity" EXACT []
synonym: "N-acetyl-D-galactosamine-6-sulfate 6-sulfohydrolase activity" EXACT []
synonym: "N-acetylgalactosamine 6-sulfatase activity" EXACT []
synonym: "N-acetylgalactosamine-6-sulfate sulfatase activity" EXACT []
xref: EC:3.1.6.4
xref: MetaCyc:3.1.6.4-RXN
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0043891
name: glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD(P)+ = 3-phospho-D-glyceroyl phosphate + NAD(P)H + H+." [EC:1.2.1.59]
subset: gosubset_prok
synonym: "D-glyceraldehyde 3-phosphate:NAD(P)+ oxidoreductase (phosphorylating)" EXACT []
synonym: "glyceraldehyde-3-phosphate dehydrogenase (NAD(P)) (phosphorylating)" EXACT []
synonym: "NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase activity" EXACT [EC:1.2.1.59]
synonym: "triosephosphate dehydrogenase (NAD(P))" EXACT []
synonym: "triosephosphate dehydrogenase (NAD(P)+)" EXACT [EC:1.2.1.59]
xref: EC:1.2.1.59
xref: MetaCyc:GAPDHSYNEC-RXN
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0043892
name: methylglyoxal reductase (NADPH-dependent) activity
namespace: molecular_function
def: "Catalysis of the reaction: lactaldehyde + NADP+ = methylglyoxal + NADPH + H+." [EC:1.1.1.283]
subset: gosubset_prok
synonym: "Gre2" RELATED []
synonym: "lactaldehyde dehydrogenase (NADP+)" EXACT []
synonym: "lactaldehyde:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.283]
xref: EC:1.1.1.283
xref: MetaCyc:1.1.1.283-RXN
xref: MetaCyc:RXN-8636
xref: RHEA:21751
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0043893
name: acetate:cation symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of acetate from one side of a membrane to the other according to the reaction: acetate(out) + cation(out) = acetate(in) + cation(in)." [GOC:jl]
subset: gosubset_prok
synonym: "acetate permease" BROAD []
synonym: "acetate-cation symporter activity" EXACT []
synonym: "acetate/cation symporter activity" EXACT []
synonym: "ActP" RELATED []
synonym: "cation-acetate symporter activity" EXACT []
synonym: "cation/acetate symporter activity" EXACT []
synonym: "cation:acetate symporter activity" EXACT []
is_a: GO:0015123 ! acetate transmembrane transporter activity
is_a: GO:0015296 ! anion:cation symporter activity

[Term]
id: GO:0043894
name: acetyl-CoA synthetase acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the acetylation of residue Lys609 of the enzyme acetyl-CoA synthetase, using acetyl-CoA as substrate." [PMID:15236963]
subset: gosubset_prok
synonym: "Pat" RELATED []
synonym: "Pat enzyme" EXACT []
synonym: "protein acetyltransferase activity" BROAD []
is_a: GO:0016407 ! acetyltransferase activity

[Term]
id: GO:0043895
name: cyclomaltodextrin glucanotransferase activity
namespace: molecular_function
def: "Catalysis of the cyclization of part of a 1,4-alpha-D-glucan chain by formation of a 1,4-alpha-D-glucosidic bond." [EC:2.4.1.19]
synonym: "1,4-alpha-D-glucan 4-alpha-D-(1,4-alpha-D-glucano)-transferase (cyclizing)" EXACT []
synonym: "alpha-1,4-glucan 4-glycosyltransferase, cyclizing" RELATED []
synonym: "alpha-cyclodextrin glucanotransferase" RELATED []
synonym: "alpha-cyclodextrin glycosyltransferase" RELATED []
synonym: "Bacillus macerans amylase" RELATED []
synonym: "beta-cyclodextrin glucanotransferase" RELATED []
synonym: "beta-cyclodextrin glycosyltransferase" RELATED []
synonym: "BMA" RELATED []
synonym: "CGTase" RELATED []
synonym: "cyclodextrin glucanotransferase" BROAD []
synonym: "cyclodextrin glycosyltransferase" RELATED []
synonym: "cyclomaltodextrin glucotransferase" RELATED []
synonym: "cyclomaltodextrin glycosyltransferase" RELATED []
synonym: "gamma-cyclodextrin glycosyltransferase" RELATED []
synonym: "konchizaimu" RELATED []
synonym: "neutral-cyclodextrin glycosyltransferase" RELATED []
xref: EC:2.4.1.19
xref: MetaCyc:2.4.1.19-RXN
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0043896
name: glucan 1,6-alpha-glucosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in (1->6)-alpha-D-glucans and derived oligosaccharides." [EC:3.2.1.70]
subset: gosubset_prok
synonym: "exo-1,6-alpha-glucosidase activity" EXACT [EC:3.2.1.70]
synonym: "exo-1,6-beta-glucosidase" RELATED []
synonym: "glucan alpha-1,6-D-glucohydrolase activity" EXACT [EC:3.2.1.70]
synonym: "glucan-1,6-alpha-glucosidase activity" EXACT []
synonym: "glucodextranase activity" EXACT [EC:3.2.1.70]
synonym: "glucodextrinase" BROAD []
xref: EC:3.2.1.70
xref: MetaCyc:3.2.1.70-RXN
is_a: GO:0015926 ! glucosidase activity

[Term]
id: GO:0043897
name: glucan 1,4-alpha-maltohydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides so as to remove successive alpha-maltose residues from the non-reducing ends of the chains." [EC:3.2.1.133]
subset: gosubset_prok
synonym: "1,4-alpha-D-glucan alpha-maltohydrolase activity" EXACT []
synonym: "glucan-1,4-alpha-maltohydrolase activity" EXACT []
synonym: "maltogenic alpha-amylase activity" EXACT []
xref: EC:3.2.1.133
xref: MetaCyc:3.2.1.133-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0043898
name: 2,3-dihydroxybiphenyl 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-dihydroxybiphenyl + O2 = 2-hydroxy-6-phenylhexa-2,4-dienoic acid." [GOC:jl, PMID:15715866]
subset: gosubset_prok
synonym: "2,3-dihydroxybiphenyl-1,2-dioxygenase activity" EXACT []
synonym: "BphC" RELATED []
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0043899
name: phosphoserine:homoserine phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a phosphoryl group from phosphoserine to homoserine to form phosphohomoserine." [GOC:jl, PMID:14699121]
subset: gosubset_prok
synonym: "thrH" RELATED []
xref: EC:2.7.1.-
xref: IMG:02616
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0043900
name: regulation of multi-organism process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species." [GOC:jl]
subset: gosubset_prok
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051704 ! multi-organism process
relationship: regulates GO:0051704 ! multi-organism process

[Term]
id: GO:0043901
name: negative regulation of multi-organism process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species." [GOC:jl]
is_a: GO:0043900 ! regulation of multi-organism process
is_a: GO:0048519 ! negative regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051704 ! multi-organism process
relationship: negatively_regulates GO:0051704 ! multi-organism process

[Term]
id: GO:0043902
name: positive regulation of multi-organism process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species." [GOC:jl]
is_a: GO:0043900 ! regulation of multi-organism process
is_a: GO:0048518 ! positive regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051704 ! multi-organism process
relationship: positively_regulates GO:0051704 ! multi-organism process

[Term]
id: GO:0043903
name: regulation of symbiosis, encompassing mutualism through parasitism
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of symbiosis, an interaction between two organisms living together in more or less intimate association." [GOC:jl]
is_a: GO:0043900 ! regulation of multi-organism process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044403 ! symbiosis, encompassing mutualism through parasitism
relationship: regulates GO:0044403 ! symbiosis, encompassing mutualism through parasitism

[Term]
id: GO:0043904
name: isochorismate pyruvate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: isochorismate = salicylate + pyruvate." [GOC:jl, PMID:16248620]
subset: gosubset_prok
synonym: "IPL" EXACT []
synonym: "isochorismate-pyruvate lyase activity" EXACT []
xref: EC:4.1.3.-
xref: IMG:02661
xref: MetaCyc:RXN-1981
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0043905
name: Ser-tRNA(Thr) hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of misacylated Ser-tRNA(Thr)." [GOC:jl, PMID:15240874]
subset: gosubset_prok
synonym: "Ser-tRNAThr hydrolase activity" EXACT []
xref: EC:3.1.1.-
xref: IMG:02667
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0043906
name: Ala-tRNA(Pro) hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of misacylated Ala-tRNA(Pro)." [GOC:jl, PMID:14663147]
subset: gosubset_prok
synonym: "Ala-tRNAPro hydrolase activity" EXACT []
xref: EC:3.1.1.-
xref: IMG:02668
is_a: GO:0002161 ! aminoacyl-tRNA editing activity

[Term]
id: GO:0043907
name: Cys-tRNA(Pro) hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of misacylated Cys-tRNA(Pro)." [GOC:jl, PMID:15886196]
subset: gosubset_prok
synonym: "Cys-tRNA(Pro) deacetylase activity" EXACT []
synonym: "Cys-tRNAPro hydrolase activity" EXACT []
xref: EC:3.1.1.-
xref: IMG:02669
is_a: GO:0002161 ! aminoacyl-tRNA editing activity

[Term]
id: GO:0043908
name: Ser(Gly)-tRNA(Ala) hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of misacylated Ser-tRNA(Ala) and Gly-tRNA(Ala)." [GOC:jl, PMID:14663147]
subset: gosubset_prok
synonym: "Ser(Gly)-tRNAAla hydrolase activity" EXACT []
xref: EC:3.1.1.-
xref: IMG:02670
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0043909
name: N-acetylcitrulline deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-L-citrulline + H2O = citrulline + acetate." [GOC:jl, IMG:02799, PMID:16750290]
subset: gosubset_prok
synonym: "acetylcitrulline deacetylase activity" EXACT []
synonym: "N-acetyl-L-citrulline deacetylase activity" EXACT []
xref: EC:3.5.1.-
xref: IMG:02799
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0043910
name: ATP:coenzyme F420 adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + factor gamma-F420-2 + H+ = coenzyme F390-A + diphosphate." [GOC:jl, IMG:02803, MetaCyc:RXN-9385, PMID:7957247, PMID:8550473]
subset: gosubset_prok
synonym: "ATP:coenzyme F420 adenyltransferase activity" EXACT []
synonym: "coenzyme F390-A synthetase activity" EXACT []
xref: EC:2.7.7.-
xref: IMG:02803
xref: MetaCyc:RXN-9385
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0043911
name: D-lysine transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-lysine + 2-oxoglutarate = L-glutamate + 6-amino-2-oxohexanoate." [GOC:jl, IMG:02956, PMID:17259313]
subset: gosubset_prok
synonym: "D-lysine aminotransferase activity" EXACT []
xref: EC:2.6.1.-
xref: IMG:02956
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0043912
name: D-lysine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-lysine + O2 + H2O = 6-amino-2-oxohexanoate + NH3 + hydrogen peroxide." [GOC:jl, IMG:02957, PMID:17259313]
subset: gosubset_prok
xref: EC:1.4.3.-
xref: IMG:02957
is_a: GO:0003884 ! D-amino-acid oxidase activity

[Term]
id: GO:0043913
name: chromosome segregation-directing complex
namespace: cellular_component
def: "A trimeric protein complex which in E. coli is composed of the subunits MreB, MreC and MreD. The complex directs longitudinal cell wall synthesis, maintaining cell morphology." [GOC:jl, PMID:15612918]
subset: gosubset_prok
synonym: "chromosome segregation directing complex" EXACT []
synonym: "longitudinal peptidoglycan synthesis-directing complex" EXACT []
synonym: "MreBCD complex" NARROW []
xref: IMG:02994
is_a: GO:0098796 ! membrane protein complex

[Term]
id: GO:0043914
name: NADPH:sulfur oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADPH + H+ + sulfur = hydrogen sulfide + NADP+." [GOC:jl, PMID:17449625]
subset: gosubset_prok
synonym: "CoA-dependent NAD(P)H sulfur oxidoreductase activity" EXACT []
synonym: "coenzyme A-dependent NAD(P)H sulfur oxidoreductase activity" EXACT []
synonym: "NAD(P)H elemental sulfur oxidoreductase activity" EXACT []
synonym: "NAD(P)H sulfur oxidoreductase activity" EXACT []
synonym: "NAD(P)H sulphur oxidoreductase activity" EXACT []
synonym: "NAD(P)H:sulfur oxidoreductase activity" EXACT []
synonym: "NADPH:sulphur oxidoreductase activity" EXACT []
synonym: "NSR" EXACT []
xref: EC:1.-.-.-
xref: IMG:03008
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0043915
name: L-seryl-tRNA(Sec) kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-seryl-tRNA(Sec) = ADP + O-phospho-L-seryl-tRNA(Sec)." [GOC:jl, IMG:03019, PMID:16201757]
subset: gosubset_prok
synonym: "O-phosphoseryl-tRNA(Sec) kinase activity" EXACT []
xref: EC:2.7.1.-
xref: IMG:03019
xref: MetaCyc:RXN-10038
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0043916
name: DNA-7-methylguanine glycosylase activity
namespace: molecular_function
def: "Catalysis of the reaction: DNA containing 7-methylguanine + H2O = DNA with abasic site + 7-methylguanine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 7-methylguanine and the deoxyribose sugar to remove the 7-methylguanine, leaving an abasic site." [GOC:jl, PMID:16468998]
subset: gosubset_prok
xref: EC:3.2.2.21
xref: IMG:03021
xref: MetaCyc:3.2.2.21-RXN
is_a: GO:0003905 ! alkylbase DNA N-glycosylase activity

[Term]
id: GO:0043917
name: ribose 1,5-bisphosphate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-ribose 1,5-bisphosphate = D-ribulose 1,5-bisphosphate." [GOC:jl, IMG:03024]
subset: gosubset_prok
synonym: "ribose-1,5-bisphosphate isomerase activity" EXACT []
xref: EC:5.3.1.-
xref: IMG:03024
xref: MetaCyc:RXN-8801
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0043918
name: cadaverine aminopropyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosylmethioninamine + cadaverine = 5'-methylthioadenosine + N-(3-aminopropyl)cadaverine." [GOC:jl, IMG:00522, PMID:17545282]
subset: gosubset_prok
synonym: "cadaverine aminopropyl transferase activity" EXACT []
xref: EC:2.5.1.-
xref: IMG:00522
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0043919
name: agmatine aminopropyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: agmatine + S-adenosylmethioninamine = N1-aminopropylagmatine + 5'-methylthioadenosine." [GOC:jl, IMG:03077, PMID:15983049]
subset: gosubset_prok
synonym: "agmatine aminopropyl transferase activity" EXACT []
xref: EC:2.5.1.-
xref: IMG:03077
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0043920
name: aminopropylagmatine ureohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N1-aminopropylagmatine + H2O = spermidine + urea." [GOC:jl, IMG:03079, PMID:15983049]
subset: gosubset_prok
xref: EC:3.5.3.-
xref: IMG:03079
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0043921
name: modulation by host of viral transcription
namespace: biological_process
def: "Any process in which a host organism modulates the frequency, rate or extent of viral transcription." [GOC:jl]
synonym: "regulation by host of viral transcription" EXACT []
synonym: "regulation of viral transcription by host" EXACT []
is_a: GO:0046782 ! regulation of viral transcription
is_a: GO:0052472 ! modulation by host of symbiont transcription

[Term]
id: GO:0043922
name: negative regulation by host of viral transcription
namespace: biological_process
def: "Any process in which a host organism stops, prevents, or reduces the frequency, rate or extent of viral transcription." [GOC:jl]
synonym: "negative regulation of viral transcription by host" EXACT []
is_a: GO:0032897 ! negative regulation of viral transcription
is_a: GO:0043921 ! modulation by host of viral transcription

[Term]
id: GO:0043923
name: positive regulation by host of viral transcription
namespace: biological_process
def: "Any process in which a host organism activates or increases the frequency, rate or extent of viral transcription, the synthesis of either RNA on a template of DNA or DNA on a template of RNA." [GOC:jl]
synonym: "positive regulation of viral transcription by host" EXACT []
is_a: GO:0043921 ! modulation by host of viral transcription
is_a: GO:0050434 ! positive regulation of viral transcription

[Term]
id: GO:0043924
name: suramin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with suramin, a naphthalenesulfonic acid compound which is used in the treatment of diseases caused by trypanosomes and worms." [CHEBI:45906, GOC:jl, Wikipedia:Suramin]
synonym: "Germanin binding" EXACT []
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901681 ! sulfur compound binding

[Term]
id: GO:0043927
name: exonucleolytic nuclear-transcribed mRNA catabolic process involved in endonucleolytic cleavage-dependent decay
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5'-cap." [GOC:mtg_mpo]
is_a: GO:0000291 ! nuclear-transcribed mRNA catabolic process, exonucleolytic
intersection_of: GO:0000291 ! nuclear-transcribed mRNA catabolic process, exonucleolytic
intersection_of: part_of GO:0000294 ! nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay
relationship: part_of GO:0000294 ! nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay

[Term]
id: GO:0043928
name: exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 3'-poly(A) tail." [GOC:mtg_mpo]
xref: Reactome:REACT_100643 "mRNA Decay by 3' to 5' Exoribonuclease, Taeniopygia guttata"
xref: Reactome:REACT_103039 "mRNA Decay by 3' to 5' Exoribonuclease, Xenopus tropicalis"
xref: Reactome:REACT_104740 "mRNA Decay by 3' to 5' Exoribonuclease, Drosophila melanogaster"
xref: Reactome:REACT_105651 "mRNA Decay by 3' to 5' Exoribonuclease, Caenorhabditis elegans"
xref: Reactome:REACT_106999 "mRNA Decay by 3' to 5' Exoribonuclease, Oryza sativa"
xref: Reactome:REACT_108622 "mRNA Decay by 3' to 5' Exoribonuclease, Saccharomyces cerevisiae"
xref: Reactome:REACT_108810 "mRNA Decay by 3' to 5' Exoribonuclease, Bos taurus"
xref: Reactome:REACT_110398 "mRNA Decay by 5' to 3' Exoribonuclease, Oryza sativa"
xref: Reactome:REACT_110671 "mRNA Decay by 5' to 3' Exoribonuclease, Plasmodium falciparum"
xref: Reactome:REACT_20518 "mRNA Decay by 5' to 3' Exoribonuclease, Homo sapiens"
xref: Reactome:REACT_20619 "mRNA Decay by 3' to 5' Exoribonuclease, Homo sapiens"
xref: Reactome:REACT_28195 "mRNA Decay by 3' to 5' Exoribonuclease, Sus scrofa"
xref: Reactome:REACT_29037 "mRNA Decay by 5' to 3' Exoribonuclease, Drosophila melanogaster"
xref: Reactome:REACT_30153 "mRNA Decay by 3' to 5' Exoribonuclease, Schizosaccharomyces pombe"
xref: Reactome:REACT_34492 "mRNA Decay by 5' to 3' Exoribonuclease, Caenorhabditis elegans"
xref: Reactome:REACT_77551 "mRNA Decay by 5' to 3' Exoribonuclease, Xenopus tropicalis"
xref: Reactome:REACT_81806 "mRNA Decay by 5' to 3' Exoribonuclease, Gallus gallus"
xref: Reactome:REACT_82052 "mRNA Decay by 5' to 3' Exoribonuclease, Danio rerio"
xref: Reactome:REACT_82562 "mRNA Decay by 3' to 5' Exoribonuclease, Rattus norvegicus"
xref: Reactome:REACT_82696 "mRNA Decay by 5' to 3' Exoribonuclease, Taeniopygia guttata"
xref: Reactome:REACT_83659 "mRNA Decay by 3' to 5' Exoribonuclease, Dictyostelium discoideum"
xref: Reactome:REACT_84878 "mRNA Decay by 5' to 3' Exoribonuclease, Saccharomyces cerevisiae"
xref: Reactome:REACT_85404 "mRNA Decay by 5' to 3' Exoribonuclease, Bos taurus"
xref: Reactome:REACT_85543 "mRNA Decay by 5' to 3' Exoribonuclease, Canis familiaris"
xref: Reactome:REACT_85963 "mRNA Decay by 3' to 5' Exoribonuclease, Danio rerio"
xref: Reactome:REACT_86693 "mRNA Decay by 3' to 5' Exoribonuclease, Arabidopsis thaliana"
xref: Reactome:REACT_87904 "mRNA Decay by 3' to 5' Exoribonuclease, Gallus gallus"
xref: Reactome:REACT_88584 "mRNA Decay by 5' to 3' Exoribonuclease, Arabidopsis thaliana"
xref: Reactome:REACT_90085 "mRNA Decay by 5' to 3' Exoribonuclease, Mus musculus"
xref: Reactome:REACT_91136 "mRNA Decay by 3' to 5' Exoribonuclease, Mus musculus"
xref: Reactome:REACT_91841 "mRNA Decay by 5' to 3' Exoribonuclease, Dictyostelium discoideum"
xref: Reactome:REACT_95911 "mRNA Decay by 5' to 3' Exoribonuclease, Schizosaccharomyces pombe"
xref: Reactome:REACT_96522 "mRNA Decay by 3' to 5' Exoribonuclease, Canis familiaris"
is_a: GO:0000291 ! nuclear-transcribed mRNA catabolic process, exonucleolytic
intersection_of: GO:0000291 ! nuclear-transcribed mRNA catabolic process, exonucleolytic
intersection_of: part_of GO:0000288 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
relationship: part_of GO:0000288 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

[Term]
id: GO:0043929
name: primary ovarian follicle growth involved in double layer follicle stage
namespace: biological_process
def: "Increase in size of primary follicles including oocyte growth and granulosa and/or theca cell proliferation until more than one layer of granulosa cells is present (preantral follicle), as part of the double layer follicle stage of oogenesis." [GOC:mtg_mpo]
synonym: "primary ovarian follicle growth during double layer follicle stage" RELATED [GOC:dph, GOC:tb]
is_a: GO:0001545 ! primary ovarian follicle growth
intersection_of: GO:0001545 ! primary ovarian follicle growth
intersection_of: part_of GO:0048161 ! double layer follicle stage
relationship: part_of GO:0048161 ! double layer follicle stage

[Term]
id: GO:0043930
name: primary ovarian follicle growth involved in primary follicle stage
namespace: biological_process
def: "Increase in size of primary follicles including oocyte growth and granulosa and/or theca cell proliferation until more than one layer of granulosa cells is present (preantral follicle) as part of the primary follicle stage of oogenesis." [GOC:mtg_mpo]
synonym: "primary ovarian follicle growth during primary follicle stage" RELATED [GOC:dph, GOC:tb]
is_a: GO:0001545 ! primary ovarian follicle growth
intersection_of: GO:0001545 ! primary ovarian follicle growth
intersection_of: part_of GO:0048160 ! primary follicle stage
relationship: part_of GO:0048160 ! primary follicle stage

[Term]
id: GO:0043931
name: ossification involved in bone maturation
namespace: biological_process
def: "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in the progression of the skeleton from its formation to its mature state." [GOC:dph, GOC:mah, GOC:mtg_mpo]
synonym: "ossification involved in bone modeling" NARROW [GO_REF:0000034]
synonym: "ossification involved in skeletal development" EXACT [GOC:dph]
is_a: GO:0001503 ! ossification
intersection_of: GO:0001503 ! ossification
intersection_of: part_of GO:0070977 ! bone maturation
relationship: part_of GO:0070977 ! bone maturation

[Term]
id: GO:0043932
name: ossification involved in bone remodeling
namespace: biological_process
def: "The formation or growth of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in response to injury or other physical, physiological or environmental stress stimuli." [GO_REF:0000034, GOC:mtg_mpo]
synonym: "ossification involved in bone remodelling" RELATED []
is_a: GO:0001503 ! ossification
intersection_of: GO:0001503 ! ossification
intersection_of: part_of GO:0046849 ! bone remodeling
relationship: part_of GO:0046849 ! bone remodeling

[Term]
id: GO:0043933
name: macromolecular complex subunit organization
namespace: biological_process
alt_id: GO:0034600
alt_id: GO:0034621
def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a macromolecular complex." [GOC:mtg_mpo]
subset: gosubset_prok
synonym: "cellular macromolecular complex organization" EXACT []
synonym: "cellular macromolecular complex subunit organisation" EXACT [GOC:curators]
synonym: "cellular macromolecular complex subunit organization" EXACT []
synonym: "macromolecular complex organization" EXACT []
synonym: "macromolecular complex subunit organisation" EXACT [GOC:curators]
is_a: GO:0016043 ! cellular component organization

[Term]
id: GO:0043934
name: sporulation
namespace: biological_process
def: "The process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure. A spore is a structure that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction." [GOC:pamgo_curators]
subset: goslim_metagenomics
subset: goslim_yeast
xref: Wikipedia:Spore
is_a: GO:0044767 ! single-organism developmental process

[Term]
id: GO:0043935
name: sexual sporulation resulting in formation of a cellular spore
namespace: biological_process
def: "The formation of spores derived from the products of meiosis. A cellular spore is a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction." [GOC:pamgo_curators]
is_a: GO:0030435 ! sporulation resulting in formation of a cellular spore
is_a: GO:0034293 ! sexual sporulation
intersection_of: GO:0030435 ! sporulation resulting in formation of a cellular spore
intersection_of: part_of GO:0051321 ! meiotic cell cycle
relationship: part_of GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0043936
name: asexual sporulation resulting in formation of a cellular spore
namespace: biological_process
def: "The formation of a cellular spore derived from the products of mitosis. A cellular spore is a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction." [GOC:pamgo_curators]
is_a: GO:0030435 ! sporulation resulting in formation of a cellular spore
is_a: GO:0030436 ! asexual sporulation

[Term]
id: GO:0043937
name: regulation of sporulation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sporulation, the process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure." [GOC:pamgo_curators]
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043934 ! sporulation
relationship: regulates GO:0043934 ! sporulation

[Term]
id: GO:0043938
name: positive regulation of sporulation
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of sporulation, the process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure." [GOC:pamgo_curators]
is_a: GO:0043937 ! regulation of sporulation
is_a: GO:0051094 ! positive regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043934 ! sporulation
relationship: positively_regulates GO:0043934 ! sporulation

[Term]
id: GO:0043939
name: negative regulation of sporulation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sporulation, the process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure." [GOC:pamgo_curators]
is_a: GO:0043937 ! regulation of sporulation
is_a: GO:0051093 ! negative regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043934 ! sporulation
relationship: negatively_regulates GO:0043934 ! sporulation

[Term]
id: GO:0043940
name: regulation of sexual sporulation resulting in formation of a cellular spore
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the formation of cellular spores derived from the products of meiosis." [GOC:pamgo_curators]
is_a: GO:0034306 ! regulation of sexual sporulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043935 ! sexual sporulation resulting in formation of a cellular spore
relationship: regulates GO:0043935 ! sexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0043941
name: positive regulation of sexual sporulation resulting in formation of a cellular spore
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of the formation of cellular spores derived from the products of meiosis." [GOC:pamgo_curators]
is_a: GO:0043902 ! positive regulation of multi-organism process
is_a: GO:0043940 ! regulation of sexual sporulation resulting in formation of a cellular spore
is_a: GO:0045836 ! positive regulation of meiotic nuclear division
is_a: GO:0045881 ! positive regulation of sporulation resulting in formation of a cellular spore
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043935 ! sexual sporulation resulting in formation of a cellular spore
relationship: positively_regulates GO:0043935 ! sexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0043942
name: negative regulation of sexual sporulation resulting in formation of a cellular spore
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of cellular spores derived from the products of meiosis." [GOC:pamgo_curators]
is_a: GO:0042174 ! negative regulation of sporulation resulting in formation of a cellular spore
is_a: GO:0043901 ! negative regulation of multi-organism process
is_a: GO:0043940 ! regulation of sexual sporulation resulting in formation of a cellular spore
is_a: GO:0045835 ! negative regulation of meiotic nuclear division
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043935 ! sexual sporulation resulting in formation of a cellular spore
relationship: negatively_regulates GO:0043935 ! sexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0043943
name: regulation of asexual sporulation resulting in formation of a cellular spore
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the formation of a cellular spore derived from the products of mitosis." [GOC:pamgo_curators]
is_a: GO:0034305 ! regulation of asexual sporulation
is_a: GO:0042173 ! regulation of sporulation resulting in formation of a cellular spore
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043936 ! asexual sporulation resulting in formation of a cellular spore
relationship: regulates GO:0043936 ! asexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0043944
name: negative regulation of asexual sporulation resulting in formation of a cellular spore
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of a cellular spore derived from the products of mitosis." [GOC:pamgo_curators]
is_a: GO:0042174 ! negative regulation of sporulation resulting in formation of a cellular spore
is_a: GO:0043943 ! regulation of asexual sporulation resulting in formation of a cellular spore
is_a: GO:1903665 ! negative regulation of asexual reproduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043936 ! asexual sporulation resulting in formation of a cellular spore
relationship: negatively_regulates GO:0043936 ! asexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0043945
name: positive regulation of asexual sporulation resulting in formation of a cellular spore
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of the formation of a cellular spore derived from the products of mitosis." [GOC:pamgo_curators]
is_a: GO:0043943 ! regulation of asexual sporulation resulting in formation of a cellular spore
is_a: GO:0045881 ! positive regulation of sporulation resulting in formation of a cellular spore
is_a: GO:1903666 ! positive regulation of asexual reproduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043936 ! asexual sporulation resulting in formation of a cellular spore
relationship: positively_regulates GO:0043936 ! asexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0043946
name: positive regulation of catalytic activity in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of enzyme activity in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, GOC:tb]
subset: gosubset_prok
synonym: "activation of enzyme activity in other organism" NARROW []
synonym: "activation of enzyme activity in other organism during symbiotic interaction" NARROW []
synonym: "positive regulation of catalytic activity in other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "up regulation of enzyme activity in other organism during symbiotic interaction" RELATED []
synonym: "up-regulation of enzyme activity in other organism during symbiotic interaction" RELATED []
synonym: "upregulation of enzyme activity in other organism during symbiotic interaction" RELATED []
is_a: GO:0043085 ! positive regulation of catalytic activity
is_a: GO:0052203 ! modulation of catalytic activity in other organism involved in symbiotic interaction

[Term]
id: GO:0043947
name: positive regulation by host of symbiont catalytic activity
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of symbiont enzyme activity. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "activation by host of symbiont enzyme activity" NARROW []
synonym: "activation of symbiont enzyme activity" NARROW []
synonym: "positive regulation by host of symbiont enzyme activity" EXACT []
synonym: "up regulation by host of symbiont enzyme activity" EXACT []
synonym: "up-regulation by host of symbiont enzyme activity" EXACT []
synonym: "upregulation by host of symbiont enzyme activity" EXACT []
is_a: GO:0043946 ! positive regulation of catalytic activity in other organism involved in symbiotic interaction
is_a: GO:0052405 ! negative regulation by host of symbiont molecular function
is_a: GO:0052422 ! modulation by host of symbiont catalytic activity
intersection_of: GO:0052055 ! modulation by symbiont of host molecular function
intersection_of: positively_regulates GO:0003824 ! catalytic activity
relationship: positively_regulates GO:0003824 ! catalytic activity

[Term]
id: GO:0043948
name: positive regulation by symbiont of host catalytic activity
namespace: biological_process
def: "Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of host enzyme activity. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by symbiont of host enzyme activity" NARROW []
synonym: "activation of host enzyme activity" NARROW []
synonym: "positive regulation by symbiont of host enzyme activity" EXACT []
synonym: "up regulation by symbiont of host enzyme activity" EXACT []
synonym: "up-regulation by symbiont of host enzyme activity" EXACT []
synonym: "upregulation by symbiont of host enzyme activity" EXACT []
is_a: GO:0043947 ! positive regulation by host of symbiont catalytic activity
is_a: GO:0052056 ! negative regulation by symbiont of host molecular function
is_a: GO:0052148 ! modulation by symbiont of host catalytic activity

[Term]
id: GO:0043949
name: regulation of cAMP-mediated signaling
namespace: biological_process
def: "Any process which modulates the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response." [GOC:jl]
synonym: "regulation of cAMP-mediated signalling" EXACT []
is_a: GO:1902531 ! regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019933 ! cAMP-mediated signaling
relationship: regulates GO:0019933 ! cAMP-mediated signaling

[Term]
id: GO:0043950
name: positive regulation of cAMP-mediated signaling
namespace: biological_process
def: "Any process which activates, maintains or increases the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response." [GOC:jl]
synonym: "positive regulation of cAMP-mediated signalling" EXACT []
is_a: GO:0043949 ! regulation of cAMP-mediated signaling
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0019933 ! cAMP-mediated signaling
relationship: positively_regulates GO:0019933 ! cAMP-mediated signaling

[Term]
id: GO:0043951
name: negative regulation of cAMP-mediated signaling
namespace: biological_process
def: "Any process which stops, prevents, or reduces the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response." [GOC:jl]
synonym: "negative regulation of cAMP-mediated signalling" EXACT []
is_a: GO:0043949 ! regulation of cAMP-mediated signaling
is_a: GO:1902532 ! negative regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019933 ! cAMP-mediated signaling
relationship: negatively_regulates GO:0019933 ! cAMP-mediated signaling

[Term]
id: GO:0043952
name: protein transport by the Sec complex
namespace: biological_process
def: "The process in which unfolded proteins are transported across the cytoplasmic membrane in Gram-positive and Gram-negative bacteria by the Sec complex, in a process involving proteolytic cleavage of an N-terminal signal peptide." [GOC:pamgo_curators]
comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular structure term 'cell envelope Sec protein transport complex ; GO:0031522'. For proteins involved in bacterial Type II secretion across the outer membrane, consider annotating to 'protein secretion by the Type II secretion system ; GO:0015628'. For proteins involved in Sec-complex dependent translocation into the eukaryotic endoplasmic reticulum, consider annotating to 'SRP-dependent cotranslational protein targeting to membrane, translocation ; GO:0006616'. Note that this term is used for annotation of proteins that compose the transport complex but not the proteins being transported.
synonym: "protein secretion by the Sec complex" NARROW []
synonym: "protein translocation by the Sec complex" NARROW []
is_a: GO:0071806 ! protein transmembrane transport

[Term]
id: GO:0043953
name: protein transport by the Tat complex
namespace: biological_process
def: "The process in which folded proteins are transported across cytoplasmic membranes of bacteria and membranes of organelles derived from bacteria (chloroplasts and mitochondria) by the TAT complex." [GOC:pamgo_curators]
comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular structure term 'TAT protein translocation system complex ; GO:0033281'. Note that this term is used for annotation of proteins that compose the transport complex but not the proteins being transported.
subset: gosubset_prok
synonym: "protein secretion by the TAT complex" NARROW []
synonym: "protein translocation by the TAT complex" NARROW []
synonym: "protein translocation by the Twin-arginine translocation complex" NARROW []
is_a: GO:0071806 ! protein transmembrane transport

[Term]
id: GO:0043954
name: cellular component maintenance
namespace: biological_process
alt_id: GO:0071956
def: "The organization process that preserves a cellular component in a stable functional or structural state." [GOC:dph, GOC:jl, GOC:mah]
synonym: "cellular component maintenance at cellular level" EXACT []
is_a: GO:0016043 ! cellular component organization
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0043955
name: 3-hydroxypropionyl-CoA synthetase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxypropionate + ATP + CoA = 3-hydroxypropionyl-CoA + AMP + diphosphate." [GOC:jl, PMID:11821399]
comment: Note that this function is one of the activities of the trifunctional enzyme propionyl-coenzyme A synthase. See PMID:11821399.
subset: gosubset_prok
synonym: "3-hydroxy propionyl-CoA synthetase activity" EXACT []
synonym: "acetyl-coenzyme A synthetase" BROAD []
synonym: "acetyl-coenzyme A synthetase/GroES-like domain" NARROW []
synonym: "AMP-dependent synthetase and ligase" BROAD []
synonym: "AMP-dependent synthetase and ligase:Enoyl-CoA hydratase/isomerase" BROAD []
synonym: "enoyl-CoA hydratase/isomerase" BROAD []
xref: EC:6.2.1.-
xref: IMG:03293
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0043956
name: 3-hydroxypropionyl-CoA dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxypropionyl-CoA = acrylyl-CoA + H2O." [GOC:jl, PMID:11821399]
comment: Note that this function is one of the activities of the trifunctional enzyme propionyl-coenzyme A synthase. See PMID:11821399.
subset: gosubset_prok
synonym: "3-hydroxy propionyl-CoA dehydratase activity" EXACT []
synonym: "acetyl-coenzyme A synthetase" BROAD []
synonym: "acetyl-coenzyme A synthetase/GroES-like domain" BROAD []
synonym: "AMP-dependent synthetase and ligase" BROAD []
synonym: "AMP-dependent synthetase and ligase:Enoyl-CoA hydratase/isomerase" BROAD []
synonym: "enoyl-CoA hydratase/isomerase" BROAD []
xref: EC:4.2.1.-
xref: IMG:03294
xref: MetaCyc:RXN-6383
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0043957
name: acryloyl-CoA reductase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: acryloyl-CoA + NADPH + H+ = propionyl-CoA + NADP+." [GOC:jl, PMID:11821399]
comment: Note that this function is one of the activities of the trifunctional enzyme propionyl-coenzyme A synthase. See PMID:11821399.
subset: gosubset_prok
synonym: "acetyl-coenzyme A synthetase" BROAD []
synonym: "acetyl-coenzyme A synthetase/GroES-like domain" BROAD []
synonym: "acryloyl-CoA reductase (NADPH) activity" EXACT []
synonym: "acrylyl-CoA reductase (NADPH) activity" EXACT []
synonym: "AMP-dependent synthetase and ligase" BROAD []
synonym: "AMP-dependent synthetase and ligase:enoyl-CoA hydratase/isomerase" BROAD []
synonym: "enoyl-CoA hydratase/isomerase" BROAD []
xref: EC:1.3.1.84
xref: IMG:03302
xref: KEGG:R00919
xref: MetaCyc:RXN-9087
xref: RHEA:26456
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0043958
name: acryloyl-CoA reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: acryloyl-CoA + NADH + H+ + a reduced electron-transfer flavoprotein = propionyl-CoA + NAD+ + an oxidized electron-transfer flavoprotein." [GOC:jl, PMID:12603323]
comment: Note that this function is part of the process of L-alanine fermentation to propionate.
subset: gosubset_prok
synonym: "acryloyl-coenzyme A reductase activity" EXACT []
synonym: "acrylyl-CoA reductase (NADH)" EXACT []
synonym: "propionyl-CoA dehydrogenase" EXACT []
xref: EC:1.3.99.3
xref: IMG:01636
xref: MetaCyc:RXN-8568
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0043959
name: L-erythro-3-methylmalyl-CoA lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: propionyl-CoA + glyoxylate = L-erythro-3-methylmalyl-CoA." [GOC:jl, IMG:03303]
subset: gosubset_prok
synonym: "HpcH/HpaI aldolase" RELATED []
xref: EC:4.1.3.-
xref: IMG:03303
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0043960
name: L-erythro-3-methylmalyl-CoA dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-erythro-3-methylmalyl-CoA = mesaconyl-CoA + H2O." [GOC:jl, IMG:03304]
subset: gosubset_prok
xref: EC:4.2.1.-
xref: IMG:03304
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0043961
name: succinyl-CoA:(R)-citramalate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: succinyl-CoA + (R)-citramalate = succinate + (R)-citramalyl-CoA." [GOC:jl, IMG:03306, PMID:17259315]
subset: gosubset_prok
synonym: "L-carnitine dehydratase/bile acid-inducible protein F" RELATED []
synonym: "succinyl-CoA:(R)-citramalate CoA transferase activity" EXACT []
synonym: "succinyl-CoA:R-citramalate CoA transferase" EXACT []
xref: EC:2.8.3.-
xref: IMG:03306
xref: MetaCyc:RXN-8966
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0043962
name: negative regulation by host of symbiont adenylate cyclase-mediated signal transduction
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the symbiont organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "positive regulation by symbiont of host adenylate cyclase-mediated signal transduction; GO:0075336".
is_a: GO:0052492 ! negative regulation by host of symbiont signal transduction pathway
is_a: GO:0075332 ! modulation by host of symbiont adenylate cyclase-mediated signal transduction

[Term]
id: GO:0043963
name: modulation by symbiont of host adenylate cyclase-mediated signal transduction
namespace: biological_process
def: "Any process in which the symbiont modulates the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
subset: gosubset_prok
is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway

[Term]
id: GO:0043964
name: positive regulation by symbiont of host adenylate cyclase-mediated signal transduction
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
subset: gosubset_prok
is_a: GO:0043963 ! modulation by symbiont of host adenylate cyclase-mediated signal transduction
is_a: GO:0052028 ! positive regulation by symbiont of host signal transduction pathway

[Term]
id: GO:0043965
name: negative regulation by symbiont of host adenylate cyclase-mediated signal transduction
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
subset: gosubset_prok
is_a: GO:0043963 ! modulation by symbiont of host adenylate cyclase-mediated signal transduction
is_a: GO:0052029 ! negative regulation by symbiont of host signal transduction pathway

[Term]
id: GO:0043966
name: histone H3 acetylation
namespace: biological_process
def: "The modification of histone H3 by the addition of an acetyl group." [GOC:jl]
is_a: GO:0016573 ! histone acetylation

[Term]
id: GO:0043967
name: histone H4 acetylation
namespace: biological_process
def: "The modification of histone H4 by the addition of an acetyl group." [GOC:jl]
is_a: GO:0016573 ! histone acetylation

[Term]
id: GO:0043968
name: histone H2A acetylation
namespace: biological_process
def: "The modification of histone H2A by the addition of an acetyl group." [GOC:jl]
is_a: GO:0016573 ! histone acetylation

[Term]
id: GO:0043969
name: histone H2B acetylation
namespace: biological_process
def: "The modification of histone H2B by the addition of an acetyl group." [GOC:jl]
is_a: GO:0016573 ! histone acetylation

[Term]
id: GO:0043970
name: histone H3-K9 acetylation
namespace: biological_process
def: "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 9 of the histone." [GOC:jl]
synonym: "histone H3 acetylation at K9" EXACT []
synonym: "histone H3K9 acetylation" EXACT []
is_a: GO:0043966 ! histone H3 acetylation
is_a: GO:0061647 ! histone H3-K9 modification

[Term]
id: GO:0043971
name: histone H3-K18 acetylation
namespace: biological_process
def: "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 18 of the histone." [GOC:jl]
synonym: "histone H3 acetylation at K18" EXACT []
synonym: "histone H3K18 acetylation" EXACT []
is_a: GO:0043966 ! histone H3 acetylation

[Term]
id: GO:0043972
name: histone H3-K23 acetylation
namespace: biological_process
def: "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 23 of the histone." [GOC:jl]
synonym: "histone H3 acetylation at K23" EXACT []
synonym: "histone H3K23 acetylation" EXACT []
is_a: GO:0043966 ! histone H3 acetylation

[Term]
id: GO:0043973
name: histone H3-K4 acetylation
namespace: biological_process
def: "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 4 of the histone." [GOC:jl]
synonym: "histone H3 acetylation at K4" EXACT []
synonym: "histone H3K4 acetylation" EXACT []
is_a: GO:0043966 ! histone H3 acetylation

[Term]
id: GO:0043974
name: histone H3-K27 acetylation
namespace: biological_process
def: "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 27 of the histone." [GOC:jl]
synonym: "histone H3 acetylation at K27" EXACT []
synonym: "histone H3K27 acetylation" EXACT []
is_a: GO:0043966 ! histone H3 acetylation

[Term]
id: GO:0043975
name: histone H3-K36 acetylation
namespace: biological_process
def: "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 36 of the histone." [GOC:jl]
synonym: "histone H3 acetylation at K36" EXACT []
synonym: "histone H3K36 acetylation" EXACT []
is_a: GO:0043966 ! histone H3 acetylation

[Term]
id: GO:0043976
name: histone H3-K79 acetylation
namespace: biological_process
def: "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 79 of the histone." [GOC:jl]
synonym: "histone H3 acetylation at K79" EXACT []
synonym: "histone H3K79 acetylation" EXACT []
is_a: GO:0043966 ! histone H3 acetylation

[Term]
id: GO:0043977
name: histone H2A-K5 acetylation
namespace: biological_process
def: "The modification of histone H2A by the addition of an acetyl group to a lysine residue at position 5 of the histone." [GOC:jl]
synonym: "histone H2A acetylation at K5" EXACT []
is_a: GO:0043968 ! histone H2A acetylation

[Term]
id: GO:0043978
name: histone H2A-K9 acetylation
namespace: biological_process
def: "The modification of histone H2A by the addition of an acetyl group to a lysine residue at position 9 of the histone." [GOC:jl]
synonym: "histone H2A acetylation at K9" EXACT []
is_a: GO:0043968 ! histone H2A acetylation

[Term]
id: GO:0043979
name: histone H2B-K5 acetylation
namespace: biological_process
def: "The modification of histone H2B by the addition of an acetyl group to a lysine residue at position 5 of the histone." [GOC:jl]
synonym: "histone H2B acetylation at K5" EXACT []
is_a: GO:0043969 ! histone H2B acetylation

[Term]
id: GO:0043980
name: histone H2B-K12 acetylation
namespace: biological_process
def: "The modification of histone H2B by the addition of an acetyl group to a lysine residue at position 12 of the histone." [GOC:jl]
synonym: "histone H2B acetylation at K12" EXACT []
is_a: GO:0043969 ! histone H2B acetylation

[Term]
id: GO:0043981
name: histone H4-K5 acetylation
namespace: biological_process
def: "The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 5 of the histone." [GOC:jl]
synonym: "histone H4 acetylation at K5" EXACT []
is_a: GO:0043967 ! histone H4 acetylation

[Term]
id: GO:0043982
name: histone H4-K8 acetylation
namespace: biological_process
def: "The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 8 of the histone." [GOC:jl]
synonym: "histone H4 acetylation at K8" EXACT []
is_a: GO:0043967 ! histone H4 acetylation

[Term]
id: GO:0043983
name: histone H4-K12 acetylation
namespace: biological_process
def: "The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 12 of the histone." [GOC:jl]
synonym: "histone H4 acetylation at K12" EXACT []
is_a: GO:0043967 ! histone H4 acetylation

[Term]
id: GO:0043984
name: histone H4-K16 acetylation
namespace: biological_process
def: "The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 16 of the histone." [GOC:jl]
synonym: "histone H4 acetylation at K16" EXACT []
is_a: GO:0043967 ! histone H4 acetylation

[Term]
id: GO:0043985
name: histone H4-R3 methylation
namespace: biological_process
def: "The modification of histone H4 by addition of a methyl group to arginine at position 3 of the histone." [GOC:mah]
synonym: "histone H4 methylation at R3" EXACT []
synonym: "histone H4 R3 methylation" EXACT []
synonym: "histone H4R3me" EXACT []
is_a: GO:0034969 ! histone arginine methylation

[Term]
id: GO:0043987
name: histone H3-S10 phosphorylation
namespace: biological_process
alt_id: GO:0043986
def: "The modification of histone H3 by the addition of an phosphate group to a serine residue at position 10 of the histone." [GOC:jl]
synonym: "histone H3 phosphorylation at S10" EXACT []
synonym: "histone H3S10 phosphorylation" EXACT []
is_a: GO:0035404 ! histone-serine phosphorylation

[Term]
id: GO:0043988
name: histone H3-S28 phosphorylation
namespace: biological_process
def: "The modification of histone H3 by the addition of an phosphate group to a serine residue at position 28 of the histone." [GOC:jl]
synonym: "histone H3 phosphorylation at S28" EXACT []
synonym: "histone H3S28 phosphorylation" EXACT []
is_a: GO:0035404 ! histone-serine phosphorylation

[Term]
id: GO:0043989
name: histone H4-S1 phosphorylation
namespace: biological_process
def: "The modification of histone H4 by the addition of an phosphate group to a serine residue at position 1 of the histone." [GOC:jl]
synonym: "histone H4 phosphorylation at S1" EXACT []
synonym: "histone H4S1 phosphorylation" EXACT []
is_a: GO:0035404 ! histone-serine phosphorylation

[Term]
id: GO:0043990
name: histone H2A-S1 phosphorylation
namespace: biological_process
def: "The modification of histone H2A by the addition of an phosphate group to a serine residue at position 1 of the histone." [GOC:jl]
synonym: "histone H2A phosphorylation at S1" EXACT []
synonym: "histone H2AS1 phosphorylation" EXACT []
is_a: GO:0035404 ! histone-serine phosphorylation
is_a: GO:1990164 ! histone H2A phosphorylation

[Term]
id: GO:0043991
name: histone H2B-S14 phosphorylation
namespace: biological_process
def: "The modification of histone H2B by the addition of an phosphate group to a serine residue at position 14 of the histone." [GOC:jl]
synonym: "histone H2B phosphorylation at S14" EXACT []
synonym: "histone H2BS14 phosphorylation" EXACT []
is_a: GO:0035404 ! histone-serine phosphorylation

[Term]
id: GO:0043992
name: histone acetyltransferase activity (H3-K9 specific)
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 9) = CoA + histone H3 N6-acetyl-L-lysine (position 9)." [EC:2.3.1.48]
synonym: "histone lysine N-acetyltransferase activity (H3-K9 specific)" EXACT []
is_a: GO:0010484 ! H3 histone acetyltransferase activity
relationship: part_of GO:0043970 ! histone H3-K9 acetylation

[Term]
id: GO:0043993
name: histone acetyltransferase activity (H3-K18 specific)
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 18) = CoA + histone H3 N6-acetyl-L-lysine (position 18)." [EC:2.3.1.48]
synonym: "histone lysine N-acetyltransferase activity (H3-K18 specific)" EXACT []
is_a: GO:0010484 ! H3 histone acetyltransferase activity
relationship: part_of GO:0043971 ! histone H3-K18 acetylation

[Term]
id: GO:0043994
name: histone acetyltransferase activity (H3-K23 specific)
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 23) = CoA + histone H3 N6-acetyl-L-lysine (position 23)." [EC:2.3.1.48]
synonym: "histone lysine N-acetyltransferase activity (H3-K23 specific)" EXACT []
is_a: GO:0010484 ! H3 histone acetyltransferase activity
relationship: part_of GO:0043972 ! histone H3-K23 acetylation

[Term]
id: GO:0043995
name: histone acetyltransferase activity (H4-K5 specific)
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 5) = CoA + histone H4 N6-acetyl-L-lysine (position 5)." [EC:2.3.1.48]
synonym: "histone lysine N-acetyltransferase activity (H4-K5 specific)" EXACT []
is_a: GO:0010485 ! H4 histone acetyltransferase activity
relationship: part_of GO:0043981 ! histone H4-K5 acetylation

[Term]
id: GO:0043996
name: histone acetyltransferase activity (H4-K8 specific)
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 8) = CoA + histone H4 N6-acetyl-L-lysine (position 8)." [EC:2.3.1.48]
synonym: "histone lysine N-acetyltransferase activity (H4-K8 specific)" EXACT []
is_a: GO:0010485 ! H4 histone acetyltransferase activity
relationship: part_of GO:0043982 ! histone H4-K8 acetylation

[Term]
id: GO:0043997
name: histone acetyltransferase activity (H4-K12 specific)
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 12) = CoA + histone H4 N6-acetyl-L-lysine (position 12)." [EC:2.3.1.48]
synonym: "histone lysine N-acetyltransferase activity (H4-K12 specific)" EXACT []
is_a: GO:0010485 ! H4 histone acetyltransferase activity
relationship: part_of GO:0043983 ! histone H4-K12 acetylation

[Term]
id: GO:0043998
name: H2A histone acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + histone H2A L-lysine = CoA + histone H2A N6-acetyl-L-lysine." [EC:2.3.1.48]
synonym: "H2A histone lysine N-acetyltransferase activity" EXACT []
is_a: GO:0004402 ! histone acetyltransferase activity
relationship: part_of GO:0043968 ! histone H2A acetylation

[Term]
id: GO:0043999
name: histone acetyltransferase activity (H2A-K5 specific)
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + histone H2A L-lysine (position 5) = CoA + histone H2A N6-acetyl-L-lysine (position 5)." [EC:2.3.1.48]
synonym: "histone lysine N-acetyltransferase activity (H2A-K5 specific)" EXACT []
is_a: GO:0043998 ! H2A histone acetyltransferase activity
relationship: part_of GO:0043977 ! histone H2A-K5 acetylation

[Term]
id: GO:0044000
name: movement in host
namespace: biological_process
def: "The process in which an organism or its progeny spreads from one location to another within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
synonym: "movement of symbiont in host" EXACT []
synonym: "movement of symbiont within host" EXACT []
synonym: "movement within host" EXACT []
synonym: "symbiont movement in host" EXACT []
synonym: "symbiont movement within host" RELATED []
is_a: GO:0051814 ! movement in other organism involved in symbiotic interaction
is_a: GO:0052126 ! movement in host environment

[Term]
id: GO:0044001
name: migration in host
namespace: biological_process
def: "The directional movement of an organism from one place to another within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
synonym: "migration within host" EXACT []
is_a: GO:0044000 ! movement in host
is_a: GO:0051815 ! migration in other organism involved in symbiotic interaction

[Term]
id: GO:0044002
name: acquisition of nutrients from host
namespace: biological_process
def: "The process that begins with the production and formation of structures and molecules in an organism that are required for the acquisition and utilization of nutrients from its host organism, and the ends with the acquirement of the nutrients. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc, GOC:jl]
subset: gosubset_prok
is_a: GO:0051701 ! interaction with host
is_a: GO:0051816 ! acquisition of nutrients from other organism during symbiotic interaction

[Term]
id: GO:0044003
name: modification by symbiont of host morphology or physiology
namespace: biological_process
def: "The process in which a symbiont organism effects a change in the structure or processes of its host organism." [GOC:cc]
subset: gosubset_prok
is_a: GO:0051701 ! interaction with host
is_a: GO:0051817 ! modification of morphology or physiology of other organism involved in symbiotic interaction

[Term]
id: GO:0044004
name: disruption by symbiont of host cell
namespace: biological_process
def: "Any process in which an organism has a negative effect on the functioning of the host's cells. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
is_a: GO:0044003 ! modification by symbiont of host morphology or physiology
is_a: GO:0051818 ! disruption of cells of other organism involved in symbiotic interaction

[Term]
id: GO:0044005
name: induction by symbiont in host of tumor, nodule, or growth
namespace: biological_process
def: "The process in which an organism causes the formation of a mass of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
is_a: GO:0044003 ! modification by symbiont of host morphology or physiology
is_a: GO:0051819 ! induction of tumor, nodule, or growth in other organism involved in symbiotic interaction

[Term]
id: GO:0044006
name: induction by symbiont in host of tumor, nodule, or growth containing transformed cells
namespace: biological_process
def: "The process in which an organism causes the formation in its host organism of a growth whose cells have been transformed and continue to exist in the absence of the first organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
is_a: GO:0044005 ! induction by symbiont in host of tumor, nodule, or growth
is_a: GO:0051820 ! induction of tumor, nodule, or growth containing transformed cells in other organism involved in symbiotic interaction

[Term]
id: GO:0044007
name: dissemination or transmission of symbiont from host
namespace: biological_process
def: "The movement of an organism from a host to another host or from a host to another place in the environment. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
synonym: "dissemination or transmission of organism from host" EXACT []
is_a: GO:0051701 ! interaction with host
is_a: GO:0051821 ! dissemination or transmission of organism from other organism involved in symbiotic interaction

[Term]
id: GO:0044008
name: dissemination or transmission of symbiont from host by vector
namespace: biological_process
def: "The movement of an organism from one host to another (or another place in the environment) by means of a third organism (often an insect or other animal). The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
synonym: "dissemination or transmission of organism from host by vector" EXACT []
is_a: GO:0044007 ! dissemination or transmission of symbiont from host
is_a: GO:0051822 ! dissemination or transmission of organism from other organism by vector involved in symbiotic interaction

[Term]
id: GO:0044009
name: viral transmission by vector
namespace: biological_process
def: "The transfer of virions by means of an organism (often an insect or other animal) in order to create new infection." [GOC:cc]
is_a: GO:0019089 ! transmission of virus
is_a: GO:0044008 ! dissemination or transmission of symbiont from host by vector

[Term]
id: GO:0044010
name: single-species biofilm formation
namespace: biological_process
def: "A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription." [GOC:cc, GOC:di, GOC:tb]
subset: gosubset_prok
is_a: GO:0042710 ! biofilm formation

[Term]
id: GO:0044011
name: single-species biofilm formation on inanimate substrate
namespace: biological_process
def: "A process in which microorganisms of the same species attach to and grow on an inanimate surface such as a rock or pipe, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription." [GOC:cc]
subset: gosubset_prok
is_a: GO:0051703 ! intraspecies interaction between organisms
is_a: GO:0090609 ! single-species submerged biofilm formation

[Term]
id: GO:0044012
name: histone acetyltransferase activity (H2A-K9 specific)
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + histone H2A L-lysine (position 9) = CoA + histone H2A N6-acetyl-L-lysine (position 9)." [EC:2.3.1.48]
synonym: "histone lysine N-acetyltransferase activity (H2A-K9 specific)" EXACT []
is_a: GO:0043998 ! H2A histone acetyltransferase activity
relationship: part_of GO:0043978 ! histone H2A-K9 acetylation

[Term]
id: GO:0044013
name: H2B histone acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + histone H2B L-lysine = CoA + histone H2B N6-acetyl-L-lysine." [EC:2.3.1.48]
synonym: "H2B histone lysine N-acetyltransferase activity" EXACT []
is_a: GO:0004402 ! histone acetyltransferase activity
relationship: part_of GO:0043969 ! histone H2B acetylation

[Term]
id: GO:0044014
name: histone acetyltransferase activity (H2B-K5 specific)
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + histone H2B L-lysine (position 5) = CoA + histone H2B N6-acetyl-L-lysine (position 5)." [EC:2.3.1.48]
synonym: "histone lysine N-acetyltransferase activity (H2B-K5 specific)" EXACT []
is_a: GO:0044013 ! H2B histone acetyltransferase activity
relationship: part_of GO:0043979 ! histone H2B-K5 acetylation

[Term]
id: GO:0044015
name: histone acetyltransferase activity (H2B-K12 specific)
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + histone H2B L-lysine (position 12) = CoA + histone H2B N6-acetyl-L-lysine (position 12)." [EC:2.3.1.48]
synonym: "histone lysine N-acetyltransferase activity (H2B-K12 specific)" EXACT []
is_a: GO:0044013 ! H2B histone acetyltransferase activity
relationship: part_of GO:0043980 ! histone H2B-K12 acetylation

[Term]
id: GO:0044016
name: histone acetyltransferase activity (H3-K4 specific)
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 4) = CoA + histone H3 N6-acetyl-L-lysine (position 4)." [EC:2.3.1.48]
synonym: "histone lysine N-acetyltransferase activity (H3-K4 specific)" EXACT []
is_a: GO:0010484 ! H3 histone acetyltransferase activity
relationship: part_of GO:0043973 ! histone H3-K4 acetylation

[Term]
id: GO:0044017
name: histone acetyltransferase activity (H3-K27 specific)
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 27) = CoA + histone H3 N6-acetyl-L-lysine (position 27)." [EC:2.3.1.48]
synonym: "histone lysine N-acetyltransferase activity (H3-K27 specific)" EXACT []
is_a: GO:0010484 ! H3 histone acetyltransferase activity
relationship: part_of GO:0043974 ! histone H3-K27 acetylation

[Term]
id: GO:0044018
name: histone acetyltransferase activity (H3-K36 specific)
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 36) = CoA + histone H3 N6-acetyl-L-lysine (position 36)." [EC:2.3.1.48]
synonym: "histone lysine N-acetyltransferase activity (H3-K36 specific)" EXACT []
is_a: GO:0010484 ! H3 histone acetyltransferase activity
relationship: part_of GO:0043975 ! histone H3-K36 acetylation

[Term]
id: GO:0044019
name: histone acetyltransferase activity (H3-K72 specific)
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 72) = CoA + histone H3 N6-acetyl-L-lysine (position 72)." [EC:2.3.1.48]
synonym: "histone lysine N-acetyltransferase activity (H3-K72 specific)" EXACT []
is_a: GO:0010484 ! H3 histone acetyltransferase activity

[Term]
id: GO:0044020
name: histone methyltransferase activity (H4-R3 specific)
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + (histone H4)-arginine (position 3) = S-adenosyl-L-homocysteine + (histone H4)-N-methyl-arginine (position 3). This reaction is the addition of a methyl group to arginine at position 3 of histone H4." [EC:2.1.1.125, GOC:mah, PMID:17898714]
synonym: "histone methylase activity (H4-R3 specific)" EXACT [GOC:mah]
synonym: "histone-arginine N-methyltransferase activity (H4-R3 specific)" EXACT []
is_a: GO:0008469 ! histone-arginine N-methyltransferase activity
relationship: part_of GO:0043985 ! histone H4-R3 methylation

[Term]
id: GO:0044022
name: histone kinase activity (H3-S28 specific)
namespace: molecular_function
def: "Catalysis of the transfer of a phosphate group to the serine-28 residue of the N-terminal tail of histone H3." [GOC:jl]
synonym: "histone serine kinase activity (H3-S28 specific)" EXACT []
synonym: "histone-serine kinase activity (H3-S28 specific)" EXACT []
is_a: GO:0035174 ! histone serine kinase activity
relationship: part_of GO:0043988 ! histone H3-S28 phosphorylation

[Term]
id: GO:0044023
name: histone kinase activity (H4-S1 specific)
namespace: molecular_function
def: "Catalysis of the transfer of a phosphate group to the serine-1 residue of the N-terminal tail of histone H4." [GOC:jl]
synonym: "histone serine kinase activity (H4-S1 specific)" EXACT []
synonym: "histone-serine kinase activity (H4-S1 specific)" EXACT []
is_a: GO:0035174 ! histone serine kinase activity
relationship: part_of GO:0043989 ! histone H4-S1 phosphorylation

[Term]
id: GO:0044024
name: histone kinase activity (H2A-S1 specific)
namespace: molecular_function
def: "Catalysis of the transfer of a phosphate group to the serine-1 residue of the N-terminal tail of histone H2A." [GOC:jl]
synonym: "histone serine kinase activity (H2A-S1 specific)" EXACT []
synonym: "histone-serine kinase activity (H2A-S1 specific)" EXACT []
is_a: GO:0035174 ! histone serine kinase activity
relationship: part_of GO:0043990 ! histone H2A-S1 phosphorylation

[Term]
id: GO:0044025
name: histone kinase activity (H2B-S14 specific)
namespace: molecular_function
def: "Catalysis of the transfer of a phosphate group to the serine-14 or an equivalent residue of the N-terminal tail of histone H2B." [GOC:jl]
synonym: "histone serine kinase activity (H2B-S14 specific)" EXACT []
synonym: "histone-serine kinase activity (H2B-S14 specific)" EXACT []
is_a: GO:0035174 ! histone serine kinase activity
relationship: part_of GO:0043991 ! histone H2B-S14 phosphorylation

[Term]
id: GO:0044026
name: DNA hypermethylation
namespace: biological_process
def: "An increase in the epigenetic methylation of cytosine and adenosine residues in DNA." [GOC:jl, http://en.wiktionary.org/]
is_a: GO:0044030 ! regulation of DNA methylation

[Term]
id: GO:0044027
name: hypermethylation of CpG island
namespace: biological_process
def: "An increase in the epigenetic methylation of cytosine and adenosine residues in a CpG island in DNA. CpG islands are genomic regions that contain a high frequency of the CG dinucleotide and are often associated with the transcription start site of genes." [GOC:jl, Wikipedia:Cpg_island]
synonym: "DNA hypermethylation of CpG island" EXACT []
is_a: GO:0044026 ! DNA hypermethylation

[Term]
id: GO:0044028
name: DNA hypomethylation
namespace: biological_process
def: "An decrease in the epigenetic methylation of cytosine and adenosine residues in DNA." [GOC:jl, http://en.wiktionary.org/hypomethylation]
is_a: GO:0044030 ! regulation of DNA methylation

[Term]
id: GO:0044029
name: hypomethylation of CpG island
namespace: biological_process
def: "An decrease in the epigenetic methylation of cytosine and adenosine residues in a CpG island in DNA. CpG islands are genomic regions that contain a high frequency of the CG dinucleotide and are often associated with the transcription start site of genes." [GOC:jl, Wikipedia:Cpg_island]
synonym: "DNA hypomethylation of CpG island" EXACT []
is_a: GO:0044028 ! DNA hypomethylation

[Term]
id: GO:0044030
name: regulation of DNA methylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine." [GOC:jl]
is_a: GO:0051052 ! regulation of DNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006306 ! DNA methylation
relationship: regulates GO:0006306 ! DNA methylation

[Term]
id: GO:0044031
name: modification by symbiont of host protein by phosphorylation
namespace: biological_process
def: "The process in which an organism adds a phosphate group to a protein of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is intended for use in annotation of symbiont gene products. For host gene products that phosphorylate host proteins, consider annotation to 'protein amino acid phosphorylation ; GO:0006468'. Consider also annotation to the molecular function term 'protein kinase activity ; GO:0004672'.
subset: gosubset_prok
is_a: GO:0075345 ! modification by symbiont of host protein

[Term]
id: GO:0044032
name: modulation by symbiont of indole acetic acid levels in host
namespace: biological_process
def: "The alteration by an organism of the levels of indole acetic acid in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is intended for use in annotation of symbiont gene products. For host gene products that regulate indole acetic acid levels in the host, consider annotating to 'auxin homeostasis ; GO:0010252'.
synonym: "modulation by symbiont of auxin levels in host" BROAD []
synonym: "modulation by symbiont of IAA levels in host" EXACT []
is_a: GO:0052019 ! modulation by symbiont of host hormone or growth regulator levels

[Term]
id: GO:0044033
name: multi-organism metabolic process
namespace: biological_process
def: "A metabolic process - chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances - which involves more than one organism." [GOC:jl]
subset: gosubset_prok
synonym: "multi-organism metabolism" EXACT []
synonym: "multi-organismal metabolic process" EXACT []
synonym: "multi-organismal metabolism" EXACT []
is_a: GO:0008152 ! metabolic process
is_a: GO:0051704 ! multi-organism process

[Term]
id: GO:0044034
name: multi-organism biosynthetic process
namespace: biological_process
def: "A biosynthetic process - chemical reactions and pathways resulting in the formation of substances - which involves more than one organism." [GOC:jl]
subset: gosubset_prok
synonym: "multi-organism biosynthesis" EXACT []
synonym: "multi-organismal biosynthesis" EXACT []
synonym: "multi-organismal biosynthetic process" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0044033 ! multi-organism metabolic process

[Term]
id: GO:0044035
name: multi-organism catabolic process
namespace: biological_process
def: "A catabolic process - chemical reactions and pathways resulting in the breakdown of substances - which involves more than one organism." [GOC:jl]
subset: gosubset_prok
synonym: "multi-organism catabolism" EXACT []
synonym: "multi-organismal catabolic process" EXACT []
synonym: "multi-organismal catabolism" EXACT []
is_a: GO:0009056 ! catabolic process
is_a: GO:0044033 ! multi-organism metabolic process

[Term]
id: GO:0044036
name: cell wall macromolecule metabolic process
namespace: biological_process
alt_id: GO:0010382
def: "The chemical reactions and pathways involving macromolecules forming, or destined to form, part of the cell wall. A cell wall is a rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:jl, GOC:mah]
synonym: "cellular cell wall macromolecule metabolic process" EXACT []
synonym: "cellular cell wall macromolecule metabolism" EXACT []
is_a: GO:0044260 ! cellular macromolecule metabolic process
relationship: part_of GO:0071554 ! cell wall organization or biogenesis

[Term]
id: GO:0044037
name: multi-organism cell wall macromolecule metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving macromolecules forming, or destined to form, part of a cell wall, involving more than one organism. A cell wall is a rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:mah, GOC:tair_curators]
subset: gosubset_prok
synonym: "multi-organism cell wall macromolecule metabolism" EXACT [GOC:mah]
is_a: GO:0044033 ! multi-organism metabolic process
is_a: GO:0044036 ! cell wall macromolecule metabolic process
is_a: GO:0044764 ! multi-organism cellular process

[Term]
id: GO:0044038
name: cell wall macromolecule biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a macromolecule destined to form part of a cell wall." [GOC:go_curators]
subset: gosubset_prok
synonym: "cell wall macromolecule anabolism" EXACT [GOC:mah]
synonym: "cell wall macromolecule biosynthesis" EXACT [GOC:mah]
synonym: "cell wall macromolecule biosynthetic process at cellular level" EXACT [GOC:mah]
synonym: "cell wall macromolecule synthesis" EXACT [GOC:mah]
synonym: "cellular cell wall macromolecule biosynthetic process" EXACT [GOC:mah]
is_a: GO:0044036 ! cell wall macromolecule metabolic process
is_a: GO:0070589 ! cellular component macromolecule biosynthetic process
relationship: part_of GO:0042546 ! cell wall biogenesis

[Term]
id: GO:0044040
name: multi-organism carbohydrate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, that involve more than one organism." [GOC:jl]
subset: gosubset_prok
synonym: "main pathways of carbohydrate metabolic process" NARROW []
synonym: "main pathways of carbohydrate metabolism" NARROW []
synonym: "multi-organism carbohydrate metabolism" EXACT []
is_a: GO:0005975 ! carbohydrate metabolic process
is_a: GO:0044033 ! multi-organism metabolic process

[Term]
id: GO:0044041
name: multi-organism carbohydrate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, involving more than one organism." [GOC:jl]
subset: gosubset_prok
synonym: "multi-organism carbohydrate breakdown" EXACT []
synonym: "multi-organism carbohydrate catabolism" EXACT []
synonym: "multi-organism carbohydrate degradation" EXACT []
is_a: GO:0016052 ! carbohydrate catabolic process
is_a: GO:0044035 ! multi-organism catabolic process
is_a: GO:0044040 ! multi-organism carbohydrate metabolic process

[Term]
id: GO:0044042
name: glucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues." [GOC:jl]
subset: gosubset_prok
synonym: "glucan metabolism" EXACT []
is_a: GO:0005976 ! polysaccharide metabolic process

[Term]
id: GO:0044043
name: multi-organism glucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues, involving more than one organism." [ISBN:0198547684]
subset: gosubset_prok
synonym: "multi-organism glucan metabolism" EXACT []
is_a: GO:0044040 ! multi-organism carbohydrate metabolic process
is_a: GO:0044042 ! glucan metabolic process

[Term]
id: GO:0044044
name: interaction with host via substance in symbiont surface
namespace: biological_process
def: "An interaction with the host organism mediated by a substance on the surface of the other (symbiont) organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk]
subset: gosubset_prok
is_a: GO:0051701 ! interaction with host

[Term]
id: GO:0044045
name: interaction with host via substance in symbiont cell outer membrane
namespace: biological_process
def: "An interaction with the host organism mediated by a substance in the symbiont cell outer membrane - a lipid bilayer that forms the outermost layer of the symbiont cell envelope. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk]
subset: gosubset_prok
is_a: GO:0044044 ! interaction with host via substance in symbiont surface

[Term]
id: GO:0044046
name: interaction with host via substance released outside of symbiont
namespace: biological_process
def: "An interaction with the host organism mediated by a substance that is released by the other organism. This includes substances that are released via pathogen cell lysis." [MITRE:tk]
subset: gosubset_prok
synonym: "interaction with host via substance released outside of symbiont cells" EXACT []
is_a: GO:0051701 ! interaction with host

[Term]
id: GO:0044047
name: interaction with host via protein secreted by type I secretion system
namespace: biological_process
def: "An interaction with the host organism mediated by a substance secreted by the other (symbiont) organism via a type I secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk]
subset: gosubset_prok
is_a: GO:0052048 ! interaction with host via secreted substance involved in symbiotic interaction

[Term]
id: GO:0044048
name: interaction with host via protein secreted by type V secretion system
namespace: biological_process
def: "An interaction with the host organism mediated by a substance secreted by the other (symbiont) organism via a type V secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk]
is_a: GO:0052048 ! interaction with host via secreted substance involved in symbiotic interaction

[Term]
id: GO:0044049
name: interaction with host via protein secreted by type VI secretion system
namespace: biological_process
def: "An interaction with the host organism mediated by a substance secreted by the other (symbiont) organism via a type VI secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk]
is_a: GO:0052048 ! interaction with host via secreted substance involved in symbiotic interaction

[Term]
id: GO:0044050
name: interaction with host via substance released by sporangium lysis
namespace: biological_process
def: "An interaction with the host organism mediated by a substance released via rupture of symbiont sporangia, structures producing and containing spores. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk]
subset: gosubset_prok
synonym: "interaction with host via substance released by lysis of symbiont sporangium" RELATED []
synonym: "interaction with host via substance released by sporangia lysis" EXACT []
is_a: GO:0044046 ! interaction with host via substance released outside of symbiont

[Term]
id: GO:0044051
name: interaction with host via substance released by symbiont cytolysis
namespace: biological_process
def: "An interaction with the host organism mediated by a substance released via cytolysis of symbiont cells. Cytolysis is the rupture of cell membranes and the loss of cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk]
subset: gosubset_prok
synonym: "interaction with host via substance released by cytolysis of symbiont" EXACT []
is_a: GO:0044046 ! interaction with host via substance released outside of symbiont

[Term]
id: GO:0044052
name: interaction with host via substance released by membrane budding
namespace: biological_process
def: "An interaction with the host organism mediated by a substance released via symbiont membrane budding, the evagination of a membrane resulting in formation of a vesicle." [MITRE:tk]
subset: gosubset_prok
synonym: "interaction with host via substance released by symbiont membrane budding" EXACT []
is_a: GO:0044046 ! interaction with host via substance released outside of symbiont

[Term]
id: GO:0044053
name: translocation of peptides or proteins into host cell cytoplasm
namespace: biological_process
def: "The directed movement of peptides or proteins produced by a symbiont organism to a location within the host cell cytoplasm." [MITRE:tk]
subset: gosubset_prok
synonym: "translocation of symbiont peptides or proteins into host cell cytoplasm" EXACT []
synonym: "transport of peptides or proteins into host cell cytoplasm" EXACT []
is_a: GO:0042000 ! translocation of peptides or proteins into host

[Term]
id: GO:0044054
name: rounding by symbiont of host cells
namespace: biological_process
def: "Any process in which an organism causes host cells to change shape and become round." [MITRE:tk]
subset: gosubset_prok
is_a: GO:0044004 ! disruption by symbiont of host cell

[Term]
id: GO:0044055
name: modulation by symbiont of host system process
namespace: biological_process
def: "The alteration by a symbiont organism of the functioning of a system process in the host. A system process is a multicellular organismal process carried out by any of the organs or tissues in an organ system." [MITRE:tk]
subset: gosubset_prok
synonym: "regulation by symbiont of host system process" EXACT []
is_a: GO:0044003 ! modification by symbiont of host morphology or physiology
is_a: GO:0044057 ! regulation of system process

[Term]
id: GO:0044056
name: modulation by symbiont of host digestive system process
namespace: biological_process
def: "The alteration by a symbiont organism of the functioning of a digestive system process, a physical, chemical, or biochemical process carried out by the host organism to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [MITRE:tk]
synonym: "regulation by symbiont of host digestive system process" EXACT []
is_a: GO:0044055 ! modulation by symbiont of host system process
is_a: GO:0044058 ! regulation of digestive system process

[Term]
id: GO:0044057
name: regulation of system process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system." [GOC:jl]
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003008 ! system process
relationship: regulates GO:0003008 ! system process

[Term]
id: GO:0044058
name: regulation of digestive system process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:jl]
is_a: GO:0044057 ! regulation of system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0022600 ! digestive system process
relationship: regulates GO:0022600 ! digestive system process

[Term]
id: GO:0044059
name: modulation by symbiont of host endocrine process
namespace: biological_process
def: "The alteration by a symbiont organism of the functioning of a endocrine process, any of the hormonal, neural, and secretory processes that release products into the blood or lymph, in the host organism." [MITRE:tk]
subset: gosubset_prok
synonym: "regulation by symbiont of host endocrine process" EXACT []
is_a: GO:0044055 ! modulation by symbiont of host system process
is_a: GO:0044060 ! regulation of endocrine process

[Term]
id: GO:0044060
name: regulation of endocrine process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of an endocrine process, a process involving the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system." [GOC:jl]
synonym: "regulation of endocrine system process" EXACT []
is_a: GO:0044057 ! regulation of system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050886 ! endocrine process
relationship: regulates GO:0050886 ! endocrine process

[Term]
id: GO:0044061
name: modulation by symbiont of host excretion
namespace: biological_process
def: "The alteration by a symbiont organism of the functioning of excretion, the elimination by the host organism of the waste products that arise as a result of metabolic activity." [MITRE:tk]
subset: gosubset_prok
synonym: "regulation by symbiont of host excretion" EXACT []
is_a: GO:0044055 ! modulation by symbiont of host system process
is_a: GO:0044062 ! regulation of excretion

[Term]
id: GO:0044062
name: regulation of excretion
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of excretion, the elimination by an organism of the waste products that arise as a result of metabolic activity." [GOC:jl]
is_a: GO:0044057 ! regulation of system process
is_a: GO:0051046 ! regulation of secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007588 ! excretion
relationship: regulates GO:0007588 ! excretion

[Term]
id: GO:0044063
name: modulation by symbiont of host neurological system process
namespace: biological_process
def: "The alteration by a symbiont organism of the functioning of a host neurophysiological process, an organ system process carried out by any of the organs or tissues of neurological system." [MITRE:tk]
subset: gosubset_prok
synonym: "regulation by symbiont of host neurological system process" EXACT []
is_a: GO:0031644 ! regulation of neurological system process
is_a: GO:0044055 ! modulation by symbiont of host system process

[Term]
id: GO:0044064
name: modulation by symbiont of host respiratory system process
namespace: biological_process
def: "The alteration by a symbiont organism of the functioning of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system." [MITRE:tk]
subset: gosubset_prok
synonym: "regulation by symbiont of host respiratory system process" EXACT []
is_a: GO:0044055 ! modulation by symbiont of host system process
is_a: GO:0044065 ! regulation of respiratory system process

[Term]
id: GO:0044065
name: regulation of respiratory system process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system." [GOC:jl]
is_a: GO:0043576 ! regulation of respiratory gaseous exchange
is_a: GO:0044057 ! regulation of system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003016 ! respiratory system process
relationship: regulates GO:0003016 ! respiratory system process

[Term]
id: GO:0044066
name: modification by symbiont of host cell nucleus
namespace: biological_process
def: "The process in which a symbiont organism effects a change in the structure or function of its host cell nucleus." [MITRE:tk]
subset: gosubset_prok
synonym: "modification by symbiont of host nucleus" EXACT []
synonym: "modification of host cell nucleus by symbiont" EXACT []
synonym: "modification of host nucleus by symbiont" EXACT []
is_a: GO:0052043 ! modification by symbiont of host cellular component

[Term]
id: GO:0044067
name: modification by symbiont of host intercellular junctions
namespace: biological_process
def: "The process in which a symbiont organism effects a change in the structure or function of its host intercellular junction, a specialized region of connection between two cells." [MITRE:tk]
subset: gosubset_prok
synonym: "modification of host intercellular junctions by symbiont" EXACT []
is_a: GO:0052043 ! modification by symbiont of host cellular component

[Term]
id: GO:0044068
name: modulation by symbiont of host cellular process
namespace: biological_process
def: "Any process in which a symbiont organism modulates the frequency, rate or extent of a cellular process, any process that is carried out at the cellular level, but not necessarily restricted to a single cell, in its host organism." [MITRE:tk]
subset: gosubset_prok
synonym: "modulation of host cellular process by symbiont" EXACT []
synonym: "regulation by symbiont of host cellular process" EXACT []
synonym: "regulation of host cellular process by symbiont" EXACT []
is_a: GO:0044003 ! modification by symbiont of host morphology or physiology
is_a: GO:0050794 ! regulation of cellular process

[Term]
id: GO:0044069
name: modulation by symbiont of host anion transport
namespace: biological_process
def: "The process in which a symbiont organism modulates the anion transport, the directed movement of anions, atoms or small molecules with a net negative charge, into, out of or within a cell, or between cells, of its host organism." [MITRE:tk]
subset: gosubset_prok
synonym: "modification of host anion transport by symbiont" EXACT []
is_a: GO:0044070 ! regulation of anion transport
is_a: GO:0052038 ! modulation by symbiont of host intracellular transport
intersection_of: GO:0044068 ! modulation by symbiont of host cellular process
intersection_of: regulates GO:0006820 ! anion transport
relationship: regulates GO:0006820 ! anion transport

[Term]
id: GO:0044070
name: regulation of anion transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of anions, atoms or small molecules with a net negative charge into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]
is_a: GO:0043269 ! regulation of ion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006820 ! anion transport
relationship: regulates GO:0006820 ! anion transport

[Term]
id: GO:0044071
name: modulation by symbiont of host cell cycle
namespace: biological_process
def: "The process in which a symbiont organism effects a change in its host's cell cycle through direct interactions with the host cell macromolecular machinery." [MITRE:tk]
subset: gosubset_prok
synonym: "modification by symbiont of host cell cycle" EXACT []
synonym: "modulation of host cell cycle by symbiont" EXACT []
synonym: "regulation by symbiont of host cell cycle" EXACT []
is_a: GO:0044068 ! modulation by symbiont of host cellular process
is_a: GO:0051726 ! regulation of cell cycle

[Term]
id: GO:0044072
name: negative regulation by symbiont of host cell cycle
namespace: biological_process
def: "The process in which a symbiont organism stops, prevents or reduces the rate or extent of its host's progression through its cell cycle via direct interactions with the host cell macromolecular machinery." [MITRE:tk]
subset: gosubset_prok
is_a: GO:0044071 ! modulation by symbiont of host cell cycle
is_a: GO:0045786 ! negative regulation of cell cycle

[Term]
id: GO:0044073
name: modulation by symbiont of host translation
namespace: biological_process
def: "The process in which a symbiont organism effects a change in translation, the chemical reactions and pathways resulting in the formation of a protein, in its host organism." [MITRE:tk]
subset: gosubset_prok
synonym: "modification by symbiont of host translation" EXACT []
synonym: "modulation of host translation by symbiont" EXACT []
synonym: "regulation by symbiont of host translation" EXACT []
is_a: GO:0006417 ! regulation of translation
is_a: GO:0044068 ! modulation by symbiont of host cellular process

[Term]
id: GO:0044074
name: negative regulation by symbiont of host translation
namespace: biological_process
def: "The process in which a symbiont organism stops, prevents, or reduces the frequency, rate or extent of translation, the chemical reactions and pathways resulting in the formation of a protein, in its host organism." [MITRE:tk]
subset: gosubset_prok
synonym: "negative regulation of host translation by symbiont" EXACT []
is_a: GO:0017148 ! negative regulation of translation
is_a: GO:0044073 ! modulation by symbiont of host translation

[Term]
id: GO:0044075
name: modulation by symbiont of host vacuole organization
namespace: biological_process
def: "Any process in which a symbiont organism modulates the frequency, rate or extent of vacuole organization in its host organism." [MITRE:tk]
subset: gosubset_prok
synonym: "modulation by symbiont of host vacuole biogenesis" RELATED [GOC:mah]
synonym: "modulation by symbiont of host vacuole organisation" EXACT [GOC:mah]
synonym: "modulation of host vacuole organization by symbiont" EXACT [GOC:mah]
synonym: "regulation by symbiont of host vacuole organization" EXACT [GOC:mah]
is_a: GO:0044068 ! modulation by symbiont of host cellular process
is_a: GO:0044088 ! regulation of vacuole organization

[Term]
id: GO:0044076
name: positive regulation by symbiont of host vacuole organization
namespace: biological_process
def: "The process in which a symbiont organism activates or increases the frequency, rate or extent of vacuole organization in its host organism." [MITRE:tk]
synonym: "positive regulation by symbiont of host vacuole biogenesis" RELATED [GOC:mah]
synonym: "positive regulation by symbiont of host vacuole organisation" EXACT [GOC:mah]
synonym: "positive regulation of host vacuole organization by symbiont" EXACT []
is_a: GO:0044075 ! modulation by symbiont of host vacuole organization
is_a: GO:0044090 ! positive regulation of vacuole organization

[Term]
id: GO:0044077
name: modulation by symbiont of host receptor-mediated endocytosis
namespace: biological_process
def: "The process in which a symbiont organism modulates the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport, in its host organism." [MITRE:tk]
subset: gosubset_prok
synonym: "modulation of host receptor-mediated endocytosis by symbiont" EXACT []
synonym: "regulation by symbiont of host receptor-mediated endocytosis" EXACT []
is_a: GO:0044068 ! modulation by symbiont of host cellular process
is_a: GO:0048259 ! regulation of receptor-mediated endocytosis

[Term]
id: GO:0044078
name: positive regulation by symbiont of host receptor-mediated endocytosis
namespace: biological_process
def: "Any process in which a symbiont organism activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport, in its host organism." [MITRE:tk]
subset: gosubset_prok
synonym: "positive regulation of host receptor-mediated endocytosis by symbiont" EXACT []
is_a: GO:0044077 ! modulation by symbiont of host receptor-mediated endocytosis
is_a: GO:0048260 ! positive regulation of receptor-mediated endocytosis

[Term]
id: GO:0044079
name: modulation by symbiont of host neurotransmitter secretion
namespace: biological_process
def: "Any process in which a symbiont organism modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell in its host organism." [MITRE:tk]
subset: gosubset_prok
synonym: "modification by symbiont of host neurotransmitter secretion" EXACT []
synonym: "modulation of host neurotransmitter secretion by symbiont" EXACT []
synonym: "regulation by symbiont of host neurotransmitter secretion" EXACT []
is_a: GO:0044063 ! modulation by symbiont of host neurological system process
is_a: GO:0044068 ! modulation by symbiont of host cellular process
is_a: GO:0046928 ! regulation of neurotransmitter secretion

[Term]
id: GO:0044080
name: modulation by symbiont of host cGMP-mediated signal transduction
namespace: biological_process
def: "Any process in which a symbiont organism modulates the rate, frequency or extent of cGMP-mediated signaling in its host organism. cGMP-mediated signaling is a series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response." [MITRE:tk]
subset: gosubset_prok
synonym: "modulation by symbiont of host cGMP-mediated signal transduction pathway" EXACT []
synonym: "modulation by symbiont of host cGMP-mediated signaling" EXACT []
synonym: "modulation by symbiont of host cGMP-mediated signalling" EXACT []
synonym: "modulation of host cGMP-mediated signal transduction by symbiont" EXACT []
synonym: "regulation by symbiont of host cGMP-mediated signal transduction" EXACT []
is_a: GO:0010752 ! regulation of cGMP-mediated signaling
is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway

[Term]
id: GO:0044081
name: modulation by symbiont of host nitric oxide-mediated signal transduction
namespace: biological_process
def: "Any process in which a symbiont organism modulates the rate, frequency or extent of nitric oxide mediated signal transduction in its host organism. Nitric oxide mediated signal transduction is a series of molecular signals mediated by the detection of nitric oxide (NO)." [MITRE:tk]
subset: gosubset_prok
synonym: "modulation by symbiont of host nitric oxide mediated signal transduction" EXACT []
synonym: "modulation of host nitric oxide-mediated signal transduction by symbiont" EXACT []
synonym: "modulation of host nitric oxide-mediated signaling by symbiont" EXACT []
synonym: "modulation of host nitric oxide-mediated signalling by symbiont" EXACT []
synonym: "regulation by symbiont of host nitric oxide-mediated signal transduction" EXACT []
is_a: GO:0010749 ! regulation of nitric oxide mediated signal transduction
is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway

[Term]
id: GO:0044082
name: modulation by symbiont of host small GTPase mediated signal transduction
namespace: biological_process
def: "Any process in which a symbiont organism modulates the frequency, rate or extent of small GTPase mediated signal transduction in its host organism." [MITRE:tk]
subset: gosubset_prok
synonym: "modulation of host small GTPase mediated signal transduction by symbiont" EXACT []
synonym: "regulation by symbiont of host small GTPase mediated signal transduction" EXACT []
is_a: GO:0051056 ! regulation of small GTPase mediated signal transduction
is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway

[Term]
id: GO:0044083
name: modulation by symbiont of host Rho protein signal transduction
namespace: biological_process
def: "Any process in which a symbiont organism modulates the frequency, rate or extent of Rho protein signal transduction in its host organism." [MITRE:tk]
subset: gosubset_prok
synonym: "modulation by symbiont of host Rho protein mediated signal transduction" EXACT []
synonym: "modulation by symbiont of host Rho protein-mediated signal transduction" EXACT []
synonym: "modulation of host Rho protein signal transduction by symbiont" EXACT []
synonym: "modulation of host Rho protein signaling by symbiont" EXACT []
synonym: "modulation of host Rho protein signalling by symbiont" EXACT []
synonym: "regulation by symbiont of host Rho protein signal transduction" EXACT []
is_a: GO:0035023 ! regulation of Rho protein signal transduction
is_a: GO:0044082 ! modulation by symbiont of host small GTPase mediated signal transduction

[Term]
id: GO:0044084
name: host cell membrane pore complex
namespace: cellular_component
def: "Any small opening in a host cell membrane that allows the passage of gases and/or liquids, composed of host proteins." [MITRE:tk]
subset: gosubset_prok
synonym: "pore complex in host cell membrane" EXACT []
is_a: GO:0033643 ! host cell part
relationship: part_of GO:0033644 ! host cell membrane

[Term]
id: GO:0044085
name: cellular component biogenesis
namespace: biological_process
alt_id: GO:0071843
def: "A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component." [GOC:jl, GOC:mah]
subset: gosubset_prok
synonym: "cellular component biogenesis at cellular level" EXACT []
is_a: GO:0071840 ! cellular component organization or biogenesis

[Term]
id: GO:0044087
name: regulation of cellular component biogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl]
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044085 ! cellular component biogenesis
relationship: regulates GO:0044085 ! cellular component biogenesis

[Term]
id: GO:0044088
name: regulation of vacuole organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole." [GOC:jl, GOC:mah]
synonym: "regulation of vacuole biogenesis" RELATED [GOC:mah]
synonym: "regulation of vacuole organisation" EXACT [GOC:mah]
is_a: GO:0033043 ! regulation of organelle organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007033 ! vacuole organization
relationship: regulates GO:0007033 ! vacuole organization

[Term]
id: GO:0044089
name: positive regulation of cellular component biogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl]
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0048518 ! positive regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044085 ! cellular component biogenesis
relationship: positively_regulates GO:0044085 ! cellular component biogenesis

[Term]
id: GO:0044090
name: positive regulation of vacuole organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole." [GOC:jl, GOC:mah]
synonym: "positive regulation of vacuole biogenesis" RELATED [GOC:mah]
synonym: "positive regulation of vacuole organisation" EXACT [GOC:mah]
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:0044088 ! regulation of vacuole organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007033 ! vacuole organization
relationship: positively_regulates GO:0007033 ! vacuole organization

[Term]
id: GO:0044091
name: membrane biogenesis
namespace: biological_process
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a membrane." [GOC:jl]
is_a: GO:0044085 ! cellular component biogenesis

[Term]
id: GO:0044092
name: negative regulation of molecular function
namespace: biological_process
def: "Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl]
is_a: GO:0065009 ! regulation of molecular function
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003674 ! molecular_function
relationship: negatively_regulates GO:0003674 ! molecular_function
created_by: jane
creation_date: 2009-04-21T04:07:27Z

[Term]
id: GO:0044093
name: positive regulation of molecular function
namespace: biological_process
def: "Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl]
is_a: GO:0065009 ! regulation of molecular function
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003674 ! molecular_function
relationship: positively_regulates GO:0003674 ! molecular_function
created_by: jane
creation_date: 2009-04-21T04:11:06Z

[Term]
id: GO:0044094
name: host cell nuclear part
namespace: cellular_component
def: "Any constituent part of a host cell's nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. The host is the larger of the organisms involved in a symbiotic interaction." [GOC:ecd]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
subset: gosubset_prok
is_a: GO:0033646 ! host intracellular part
relationship: part_of GO:0042025 ! host cell nucleus
created_by: jane
creation_date: 2009-04-22T01:59:14Z

[Term]
id: GO:0044095
name: host cell nucleoplasm
namespace: cellular_component
def: "That part of a host cell's nuclear content other than the chromosomes or the nucleolus. The host is the larger of the organisms involved in a symbiotic interaction." [GOC:ecd]
subset: gosubset_prok
is_a: GO:0044094 ! host cell nuclear part
created_by: jane
creation_date: 2009-04-22T02:02:51Z

[Term]
id: GO:0044096
name: type IV pilus
namespace: cellular_component
def: "A short filamentous structure on the surface of a bacterial cell distinguished from other pili by post-translational N-methylation of the pilin monomers." [GOC:pamgo_curators]
subset: gosubset_prok
synonym: "TFP" EXACT []
synonym: "type 4 pilus" EXACT []
synonym: "type IV fimbriae" EXACT []
is_a: GO:0009289 ! pilus
created_by: jane
creation_date: 2009-04-22T02:52:55Z

[Term]
id: GO:0044097
name: secretion by the type IV secretion system
namespace: biological_process
def: "The controlled release of proteins or DNA by a cell, via the type IV secretion system." [GOC:pamgo_curators]
synonym: "secretion via the type IV secretion system" EXACT []
is_a: GO:0032940 ! secretion by cell
created_by: jane
creation_date: 2009-06-09T02:20:34Z

[Term]
id: GO:0044098
name: DNA secretion by the type IV secretion system
namespace: biological_process
def: "The controlled release of DNA by a cell, via the type IV secretion system." [GOC:pamgo_curators]
synonym: "DNA secretion via the type IV secretion system" EXACT []
is_a: GO:0044097 ! secretion by the type IV secretion system
created_by: jane
creation_date: 2009-06-09T02:26:57Z

[Term]
id: GO:0044099
name: polar tube
namespace: cellular_component
def: "A highly specialized structure unique to microsporidia that is required for host cell invasion. In the spore, the polar tube is connected at the anterior end, and then coils around the sporoplasm. Upon appropriate environmental stimulation, the polar tube rapidly discharges out of the spore, pierces a cell membrane and serves as a conduit for sporoplasm passage into the new host cell." [GOC:mf, PMID:12076771, PMID:9723921]
is_a: GO:0044464 ! cell part
created_by: jane
creation_date: 2009-06-09T03:12:32Z

[Term]
id: GO:0044100
name: sporoplasm
namespace: cellular_component
def: "The complex infective apparatus corresponding to the central mass of cytoplasm within a spore that is injected into a host cell by various parasitic microorganisms." [GOC:mf, PMID:12076771, PMID:16004371, PMID:9723921]
is_a: GO:0044424 ! intracellular part
created_by: jane
creation_date: 2009-06-09T03:27:03Z

[Term]
id: GO:0044101
name: (R)-citramalyl-CoA lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-citramalyl-CoA = pyruvate + acetyl-CoA." [GOC:jl, IMG:03307]
subset: gosubset_prok
synonym: "Ccl" RELATED []
synonym: "R-citramalyl-CoA lyase activity" EXACT []
xref: EC:4.1.3.-
xref: IMG:03307
xref: MetaCyc:RXN-8967
is_a: GO:0016833 ! oxo-acid-lyase activity
created_by: jane
creation_date: 2009-07-09T03:14:15Z

[Term]
id: GO:0044102
name: purine deoxyribosyltransferase activity
namespace: molecular_function
def: "Catalysis of deoxyribose exchange between purine deoxyribonucleoside as a donor and purine base as an acceptor." [GOC:jl, IMG:03313, PMID:11836245]
subset: gosubset_prok
synonym: "PTD" RELATED []
synonym: "purine 2'-deoxyribosyltransferase activity" EXACT []
xref: EC:2.4.2.-
xref: IMG:03313
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups
created_by: jane
creation_date: 2009-07-09T03:40:15Z

[Term]
id: GO:0044103
name: L-arabinose 1-dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arabinose + NADP+ = L-arabinono-1,4-lactone + NADPH + H+." [GOC:jl, IMG:03333]
subset: gosubset_prok
xref: EC:1.1.1.-
xref: IMG:03333
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
created_by: jane
creation_date: 2009-07-09T04:00:30Z

[Term]
id: GO:0044104
name: 2,5-dioxovalerate dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,5-dioxopentanoate + NAD+ + H2O = 2-oxoglutarate + NADH + H+." [IMG:03338, PMID:16835232, PMID:17202142]
subset: gosubset_prok
synonym: "2,5-dioxopentanoate dehydrogenase (NAD+) activity" EXACT []
synonym: "2,5-dioxopentanoate:NAD+ 5-oxidoreductase activity" EXACT []
xref: EC:1.2.1.-
xref: IMG:03338
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
created_by: jane
creation_date: 2009-07-09T04:15:14Z

[Term]
id: GO:0044105
name: L-xylulose reductase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: xylitol + NAD+ = L-xylulose + NADH + H+." [IMG:03341, PMID:14736891]
subset: gosubset_prok
xref: EC:1.1.1.-
xref: IMG:03341
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
created_by: jane
creation_date: 2009-07-09T04:25:43Z

[Term]
id: GO:0044106
name: cellular amine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl]
is_a: GO:0009308 ! amine metabolic process
is_a: GO:0034641 ! cellular nitrogen compound metabolic process
created_by: jane
creation_date: 2009-07-15T11:55:44Z

[Term]
id: GO:0044107
name: cellular alcohol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom, as carried out by individual cells." [GOC:jl]
is_a: GO:0006066 ! alcohol metabolic process
is_a: GO:0044237 ! cellular metabolic process
is_a: GO:0044763 ! single-organism cellular process
created_by: jane
creation_date: 2009-07-15T01:36:19Z

[Term]
id: GO:0044108
name: cellular alcohol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom, carried out at the level of an individual cell." [GOC:jl]
is_a: GO:0044107 ! cellular alcohol metabolic process
is_a: GO:0044249 ! cellular biosynthetic process
is_a: GO:0046165 ! alcohol biosynthetic process
created_by: jane
creation_date: 2009-07-15T01:38:25Z

[Term]
id: GO:0044109
name: cellular alcohol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom, occurring at the level of the individual cell." [GOC:jl]
is_a: GO:0044107 ! cellular alcohol metabolic process
is_a: GO:0044248 ! cellular catabolic process
is_a: GO:0046164 ! alcohol catabolic process
created_by: jane
creation_date: 2009-07-15T01:44:27Z

[Term]
id: GO:0044110
name: growth involved in symbiotic interaction
namespace: biological_process
def: "The increase in size or mass of an organism occurring when the organism is in a symbiotic interaction." [GO:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'growth or development during symbiotic interaction ; GO:0052171'. See also 'development during symbiotic interaction ; GO:0044111'.
subset: gosubset_prok
synonym: "growth during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0040007 ! growth
is_a: GO:0051704 ! multi-organism process
intersection_of: GO:0040007 ! growth
intersection_of: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism
relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism
created_by: jane
creation_date: 2009-07-30T02:22:33Z

[Term]
id: GO:0044111
name: development involved in symbiotic interaction
namespace: biological_process
def: "The progression of an organism from an initial condition to a later condition, occurring when the organism is in a symbiotic interaction." [GO:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'growth or development during symbiotic interaction ; GO:0052171'. See also 'growth during symbiotic interaction ; GO:0044110'.
subset: gosubset_prok
synonym: "development during symbiotic interaction" RELATED [gOC:dph]
is_a: GO:0032502 ! developmental process
is_a: GO:0051704 ! multi-organism process
intersection_of: GO:0032502 ! developmental process
intersection_of: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism
relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism
created_by: jane
creation_date: 2009-07-30T02:26:46Z

[Term]
id: GO:0044112
name: growth in other organism involved in symbiotic interaction
namespace: biological_process
def: "The increase in size or mass of an organism, occurring within the cells or tissues of a second organism, where the two organisms are in a symbiotic interaction. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down the tissue of the second organism." [GOC:cc, GOC:jl]
comment: This term partially replaces the obsolete term 'growth or development in other organism during symbiotic interaction ; GO:0051831'. See also 'development in other organism during symbiotic interaction ; GO:0044113'.
synonym: "growth in other organism during symbiotic interaction" RELATED [GOC:tb]
is_a: GO:0044110 ! growth involved in symbiotic interaction
created_by: jane
creation_date: 2009-07-30T02:32:14Z

[Term]
id: GO:0044113
name: development in other organism involved in symbiotic interaction
namespace: biological_process
def: "The progression of an organism from an initial condition to a later condition, occurring within the cells or tissues of a second organism, where the two organisms are in a symbiotic interaction. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down the tissue of the second organism." [GO:jl, GOC:cc]
comment: This term partially replaces the obsolete term 'growth or development in other organism during symbiotic interaction ; GO:0051831'. See also 'growth in other organism during symbiotic interaction ; GO:0044112'.
subset: gosubset_prok
synonym: "development in other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0044111 ! development involved in symbiotic interaction
created_by: jane
creation_date: 2009-07-30T02:32:38Z

[Term]
id: GO:0044114
name: development of symbiont in host
namespace: biological_process
def: "The progression of an organism from an initial condition to a later condition, occurring within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'growth or development of symbiont in host ; GO:0044412'. See also 'growth of symbiont in host ; GO:0044117'.
subset: gosubset_prok
is_a: GO:0044115 ! development of symbiont involved in interaction with host
created_by: jane
creation_date: 2009-07-30T03:39:25Z

[Term]
id: GO:0044115
name: development of symbiont involved in interaction with host
namespace: biological_process
def: "The progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'growth or development of symbiont during interaction with host ; GO:0052108'. See also 'growth of symbiont during interaction with host ; GO:0044116'.
subset: gosubset_prok
synonym: "development of symbiont during interaction with host" RELATED [GOC:dph]
is_a: GO:0044111 ! development involved in symbiotic interaction
created_by: jane
creation_date: 2009-07-30T03:26:36Z

[Term]
id: GO:0044116
name: growth of symbiont involved in interaction with host
namespace: biological_process
def: "The increase in size or mass of an organism, occurring in, on or near the exterior of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'growth or development of symbiont during interaction with host ; GO:0052108'. See also 'development of symbiont during interaction with host ; GO:0044115'.
subset: gosubset_prok
synonym: "growth of symbiont during interaction with host" RELATED [GOC:tb]
is_a: GO:0044110 ! growth involved in symbiotic interaction
created_by: jane
creation_date: 2009-07-30T03:27:07Z

[Term]
id: GO:0044117
name: growth of symbiont in host
namespace: biological_process
def: "The increase in size or mass of an organism, occurring within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'growth or development of symbiont in host ; GO:0044412'. See also 'development of symbiont in host ; GO:0044114'.
subset: gosubset_prok
is_a: GO:0044116 ! growth of symbiont involved in interaction with host
created_by: jane
creation_date: 2009-07-30T03:39:56Z

[Term]
id: GO:0044118
name: development of symbiont in host cell
namespace: biological_process
def: "The progression of the symbiont from an initial condition to a later condition, occurring in its host's cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'growth or development of symbiont in host cell ; GO:0075065'. See also 'growth of symbiont in host cell ; GO:0044119'.
subset: gosubset_prok
is_a: GO:0044114 ! development of symbiont in host
created_by: jane
creation_date: 2009-07-30T03:52:00Z

[Term]
id: GO:0044119
name: growth of symbiont in host cell
namespace: biological_process
def: "The increase in size or mass of symbiont, occurring in its host's cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'growth or development of symbiont in host cell ; GO:0075065'. See also 'development of symbiont in host cell ; GO:0044118'. This term refers to an increase in mass of a symbiont in a host cell; it should not be used to annotate an increase in number of symbionts, e.g. viral replication in a host cell.
subset: gosubset_prok
is_a: GO:0044117 ! growth of symbiont in host
created_by: jane
creation_date: 2009-07-30T03:52:30Z

[Term]
id: GO:0044120
name: development of symbiont in host organelle
namespace: biological_process
def: "The progression of the symbiont from an initial condition to a later condition, occurring in its host's organelle. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'growth or development of symbiont in host organelle ; GO:0075066'. See also 'growth of symbiont in host organelle ; GO:0044121'.
subset: gosubset_prok
is_a: GO:0044118 ! development of symbiont in host cell
created_by: jane
creation_date: 2009-07-30T03:59:54Z

[Term]
id: GO:0044121
name: growth of symbiont in host organelle
namespace: biological_process
def: "The increase in size or mass of a symbiont, occurring in its host's organelle. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'growth or development of symbiont in host organelle ; GO:0075066'. See also 'development of symbiont in host organelle ; GO:0044120'.
subset: gosubset_prok
is_a: GO:0044119 ! growth of symbiont in host cell
created_by: jane
creation_date: 2009-07-30T04:00:25Z

[Term]
id: GO:0044122
name: development of symbiont in host vascular tissue
namespace: biological_process
def: "The progression of the symbiont from an initial condition to a later condition, occurring in its host's vascular tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'growth or development of symbiont in host organelle ; GO:0075066'. See also 'growth of symbiont in host vascular tissue ; GO:0044123'.
subset: gosubset_prok
is_a: GO:0044114 ! development of symbiont in host
created_by: jane
creation_date: 2009-07-30T04:23:43Z

[Term]
id: GO:0044123
name: growth of symbiont in host vascular tissue
namespace: biological_process
def: "The increase in size or mass of symbiont, occurring in its host's vascular tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'growth or development of symbiont in host organelle ; GO:0075066'. See also 'development of symbiont in host vascular tissue ; GO:0044122'.
subset: gosubset_prok
is_a: GO:0044117 ! growth of symbiont in host
created_by: jane
creation_date: 2009-07-30T04:24:56Z

[Term]
id: GO:0044124
name: development of symbiont in host intercellular space
namespace: biological_process
def: "The progression of the symbiont from an initial condition to a later condition, occurring in its host's intercellular space. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'growth or development of symbiont in host intercellular space ; GO:0075067'. See also 'growth of symbiont in host intercellular space ; GO:0044125'.
subset: gosubset_prok
is_a: GO:0044114 ! development of symbiont in host
created_by: jane
creation_date: 2009-07-30T04:50:34Z

[Term]
id: GO:0044125
name: growth of symbiont in host intercellular space
namespace: biological_process
def: "The increase in size or mass of symbiont, occurring in its host's intercellular space. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'growth or development of symbiont in host intercellular space ; GO:0075067'. See also 'development of symbiont in host intercellular space ; GO:0044124'.
subset: gosubset_prok
is_a: GO:0044117 ! growth of symbiont in host
created_by: jane
creation_date: 2009-07-30T04:51:07Z

[Term]
id: GO:0044126
name: regulation of growth of symbiont in host
namespace: biological_process
def: "Any process in which the symbiont regulates the increase in its size or mass within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'regulation of growth or development of symbiont in host ; GO:0033665'. See also 'regulation of development of symbiont in host ; GO:0044127'.
subset: gosubset_prok
is_a: GO:0040008 ! regulation of growth
is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044117 ! growth of symbiont in host
relationship: regulates GO:0044117 ! growth of symbiont in host
created_by: jane
creation_date: 2009-08-04T02:10:08Z

[Term]
id: GO:0044127
name: regulation of development of symbiont in host
namespace: biological_process
def: "Any process in which the symbiont regulates its progression from an initial condition to a later condition, within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'regulation of growth or development of symbiont in host ; GO:0033665'. See also 'regulation of growth of symbiont in host ; GO:0044126'.
subset: gosubset_prok
is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044114 ! development of symbiont in host
relationship: regulates GO:0044114 ! development of symbiont in host
created_by: jane
creation_date: 2009-08-04T02:11:08Z

[Term]
id: GO:0044128
name: positive regulation of growth of symbiont in host
namespace: biological_process
def: "Any process in which the symbiont activates, maintains or increases its size or mass within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'positive regulation of growth or development of symbiont in host ; GO:0033666'. See also 'positive regulation of development of symbiont in host ; GO:0044129'.
subset: gosubset_prok
is_a: GO:0044126 ! regulation of growth of symbiont in host
is_a: GO:0044148 ! positive regulation of growth of symbiont involved in interaction with host
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044117 ! growth of symbiont in host
relationship: positively_regulates GO:0044117 ! growth of symbiont in host
created_by: jane
creation_date: 2009-08-04T02:20:57Z

[Term]
id: GO:0044129
name: positive regulation of development of symbiont in host
namespace: biological_process
def: "Any process in which the symbiont activates or maintains its progression from an initial condition to a later condition, within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'positive regulation of growth or development of symbiont in host ; GO:0033666'. See also 'positive regulation of growth of symbiont in host ; GO:0044128'.
subset: gosubset_prok
is_a: GO:0044127 ! regulation of development of symbiont in host
is_a: GO:0044149 ! positive regulation of development of symbiont involved in interaction with host
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044114 ! development of symbiont in host
relationship: positively_regulates GO:0044114 ! development of symbiont in host
created_by: jane
creation_date: 2009-08-04T02:25:41Z

[Term]
id: GO:0044130
name: negative regulation of growth of symbiont in host
namespace: biological_process
def: "Any process in which the symbiont stops, prevents or reduces its increase in size or mass within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'negative regulation of growth or development of symbiont in host ; GO:0033667'. See also 'negative regulation of development of symbiont in host ; GO:0044131'.
subset: gosubset_prok
is_a: GO:0044126 ! regulation of growth of symbiont in host
is_a: GO:0044146 ! negative regulation of growth of symbiont involved in interaction with host
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044117 ! growth of symbiont in host
relationship: negatively_regulates GO:0044117 ! growth of symbiont in host
created_by: jane
creation_date: 2009-08-04T02:42:25Z

[Term]
id: GO:0044131
name: negative regulation of development of symbiont in host
namespace: biological_process
def: "Any process in which the symbiont stops, prevents or reduces its progression from an initial condition to a later condition, within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'negative regulation of growth or development of symbiont in host ; GO:0033667'. See also 'negative regulation of growth of symbiont in host ; GO:0044130'.
subset: gosubset_prok
is_a: GO:0044127 ! regulation of development of symbiont in host
is_a: GO:0044147 ! negative regulation of development of symbiont involved in interaction with host
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044114 ! development of symbiont in host
relationship: negatively_regulates GO:0044114 ! development of symbiont in host
created_by: jane
creation_date: 2009-08-04T02:42:56Z

[Term]
id: GO:0044132
name: development of symbiont on or near host
namespace: biological_process
def: "The progression of a symbiont from an initial condition to a later condition, within the cells or tissues of its host organism." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'growth or development of symbiont on or near host ; GO:0044408'. See also 'growth of symbiont on or near host ; GO:0044133'.
subset: gosubset_prok
is_a: GO:0044115 ! development of symbiont involved in interaction with host
created_by: jane
creation_date: 2009-08-04T03:36:02Z

[Term]
id: GO:0044133
name: growth of symbiont on or near host
namespace: biological_process
def: "The increase in size or mass of a symbiont within the cells or tissues of its host organism." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'growth or development of symbiont on or near host ; GO:0044408'. See also 'development of symbiont on or near host ; GO:0044132'.
subset: gosubset_prok
is_a: GO:0044116 ! growth of symbiont involved in interaction with host
created_by: jane
creation_date: 2009-08-04T03:36:49Z

[Term]
id: GO:0044134
name: development of symbiont on or near host phyllosphere
namespace: biological_process
def: "The progression of the symbiont from an initial condition to a later condition, occurring on or near its host phyllosphere. The host phyllosphere is defined as total above-ground surfaces of a plant as a habitat for symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'growth or development of symbiont on or near host phyllosphere ; GO:0075013'. See also 'growth of symbiont on or near host phyllosphere ; GO:0044135'.
is_a: GO:0044132 ! development of symbiont on or near host
created_by: jane
creation_date: 2009-08-04T04:10:58Z

[Term]
id: GO:0044135
name: growth of symbiont on or near host phyllosphere
namespace: biological_process
def: "The increase in size or mass of symbiont occurring on or near its host phyllosphere. The host phyllosphere is defined as total above-ground surfaces of a plant as a habitat for symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'growth or development of symbiont on or near host phyllosphere ; GO:0075013'. See also 'development of symbiont on or near host phyllosphere ; GO:0044134'.
is_a: GO:0044133 ! growth of symbiont on or near host
created_by: jane
creation_date: 2009-08-04T04:11:23Z

[Term]
id: GO:0044136
name: development of symbiont on or near host rhizosphere
namespace: biological_process
def: "The progression of the symbiont from an initial condition to a later condition, occurring on or near its host rhizosphere. The host rhizosphere is defined as total below-ground surfaces of a plant as a habitat for its symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'growth or development of symbiont on or near host rhizosphere ; GO:0075014'. See also 'growth of symbiont on or near host rhizosphere ; GO:0044137'.
subset: gosubset_prok
is_a: GO:0044132 ! development of symbiont on or near host
created_by: jane
creation_date: 2009-08-04T04:18:35Z

[Term]
id: GO:0044137
name: growth of symbiont on or near host rhizosphere
namespace: biological_process
def: "The increase in size or mass of symbiont occurring on or near its host rhizosphere. The host rhizosphere is defined as total below-ground surfaces of a plant as a habitat for its symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'growth or development of symbiont on or near host rhizosphere ; GO:0075014'. See also 'development of symbiont on or near host rhizosphere ; GO:0044136'.
subset: gosubset_prok
is_a: GO:0044133 ! growth of symbiont on or near host
created_by: jane
creation_date: 2009-08-04T04:19:07Z

[Term]
id: GO:0044138
name: modulation of development of symbiont on or near host
namespace: biological_process
def: "Any process in which the symbiont regulates its progression from an initial condition to a later condition, on or near the cells or tissues of the host organism." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'modulation of growth or development of symbiont on or near host ; GO:0075305'. See also 'modulation of growth of symbiont on or near host ; GO:0044139'.
subset: gosubset_prok
is_a: GO:0044145 ! modulation of development of symbiont involved in interaction with host
relationship: regulates GO:0044132 ! development of symbiont on or near host
created_by: jane
creation_date: 2009-08-04T04:24:25Z

[Term]
id: GO:0044139
name: modulation of growth of symbiont on or near host
namespace: biological_process
def: "Any process in which the symbiont regulates the increase in its size or mass on or near the cells or tissues of the host organism." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'modulation of growth or development of symbiont on or near host ; GO:0075305'. See also 'modulation of development of symbiont on or near host ; GO:0044138'.
subset: gosubset_prok
is_a: GO:0044144 ! modulation of growth of symbiont involved in interaction with host
relationship: regulates GO:0044133 ! growth of symbiont on or near host
created_by: jane
creation_date: 2009-08-04T04:24:59Z

[Term]
id: GO:0044140
name: negative regulation of growth of symbiont on or near host surface
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the increase in the symbiont's size or mass on or near the cells or tissues of the host organism." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'negative regulation of growth or development of symbiont on or near host surface ; GO:0075309'. See also 'negative regulation of development of symbiont on or near host surface ; GO:0044141'.
subset: gosubset_prok
is_a: GO:0044139 ! modulation of growth of symbiont on or near host
is_a: GO:0044146 ! negative regulation of growth of symbiont involved in interaction with host
relationship: negatively_regulates GO:0044133 ! growth of symbiont on or near host
created_by: jane
creation_date: 2009-08-04T04:31:26Z

[Term]
id: GO:0044141
name: negative regulation of development of symbiont on or near host surface
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the symbiont's progression from an initial condition to a later condition, on or near the cells or tissues of the host organism." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'negative regulation of growth or development of symbiont on or near host surface ; GO:0075309'. See also 'negative regulation of growth of symbiont on or near host surface ; GO:0044140'.
subset: gosubset_prok
is_a: GO:0044138 ! modulation of development of symbiont on or near host
is_a: GO:0044147 ! negative regulation of development of symbiont involved in interaction with host
relationship: negatively_regulates GO:0044132 ! development of symbiont on or near host
created_by: jane
creation_date: 2009-08-04T04:32:18Z

[Term]
id: GO:0044142
name: positive regulation of growth of symbiont on or near host surface
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the symbiont's increase in size or mass on or near the cells or tissues of the host organism." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'positive regulation of growth or development of symbiont on or near host surface ; GO:0075337'. See also 'positive regulation of development of symbiont on or near host surface ; GO:0044143'.
subset: gosubset_prok
is_a: GO:0044139 ! modulation of growth of symbiont on or near host
is_a: GO:0044148 ! positive regulation of growth of symbiont involved in interaction with host
relationship: positively_regulates GO:0044133 ! growth of symbiont on or near host
created_by: jane
creation_date: 2009-08-06T01:35:18Z

[Term]
id: GO:0044143
name: positive regulation of development of symbiont on or near host surface
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the symbiont's progression from an initial condition to a later condition, on or near the cells or tissues of the host organism." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'positive regulation of growth or development of symbiont on or near host surface ; GO:0075337'. See also 'positive regulation of growth of symbiont on or near host surface ; GO:0044142'.
subset: gosubset_prok
is_a: GO:0044138 ! modulation of development of symbiont on or near host
is_a: GO:0044149 ! positive regulation of development of symbiont involved in interaction with host
relationship: positively_regulates GO:0044132 ! development of symbiont on or near host
created_by: jane
creation_date: 2009-08-06T01:35:48Z

[Term]
id: GO:0044144
name: modulation of growth of symbiont involved in interaction with host
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the increase in size or mass of an organism occurring in, on or near the exterior of its host organism." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'modulation of growth or development of symbiont during interaction with host ; GO:0075338'. See also 'modulation of development of symbiont during interaction with host ; GO:0044145'.
subset: gosubset_prok
synonym: "modulation of growth of symbiont during interaction with host" RELATED [GOC:tb]
is_a: GO:0040008 ! regulation of growth
is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism
relationship: regulates GO:0044116 ! growth of symbiont involved in interaction with host
created_by: jane
creation_date: 2009-08-06T01:56:48Z

[Term]
id: GO:0044145
name: modulation of development of symbiont involved in interaction with host
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'modulation of growth or development of symbiont during interaction with host ; GO:0075338'. See also 'modulation of growth of symbiont during interaction with host ; GO:0044144'.
subset: gosubset_prok
synonym: "modulation of development of symbiont during interaction with host" RELATED [GOC:dph]
is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0044115 ! development of symbiont involved in interaction with host
created_by: jane
creation_date: 2009-08-06T01:57:38Z

[Term]
id: GO:0044146
name: negative regulation of growth of symbiont involved in interaction with host
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the increase in size or mass of an organism occurring in, on or near the exterior of its host organism." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'negative regulation of growth or development of symbiont during interaction with host ; GO:0075340'. See also 'negative regulation of development of symbiont during interaction with host ; GO:0044147'.
subset: gosubset_prok
synonym: "negative regulation of growth of symbiont during interaction with host" RELATED [GOC:tb]
is_a: GO:0043901 ! negative regulation of multi-organism process
is_a: GO:0044144 ! modulation of growth of symbiont involved in interaction with host
is_a: GO:0045926 ! negative regulation of growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044116 ! growth of symbiont involved in interaction with host
relationship: negatively_regulates GO:0044116 ! growth of symbiont involved in interaction with host
created_by: jane
creation_date: 2009-08-06T02:04:24Z

[Term]
id: GO:0044147
name: negative regulation of development of symbiont involved in interaction with host
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'negative regulation of growth or development of symbiont during interaction with host ; GO:0075340'. See also 'negative regulation of growth of symbiont during interaction with host ; GO:0044146'.
synonym: "negative regulation of development of symbiont during interaction with host" RELATED [GOC:dph]
is_a: GO:0043901 ! negative regulation of multi-organism process
is_a: GO:0044145 ! modulation of development of symbiont involved in interaction with host
is_a: GO:0051093 ! negative regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044115 ! development of symbiont involved in interaction with host
relationship: negatively_regulates GO:0044115 ! development of symbiont involved in interaction with host
created_by: jane
creation_date: 2009-08-06T02:04:59Z

[Term]
id: GO:0044148
name: positive regulation of growth of symbiont involved in interaction with host
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the increase in size or mass of an organism occurring in, on or near the exterior of its host organism." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'positive regulation of growth or development of symbiont during interaction with host ; GO:0075339'. See also 'positive regulation of development of symbiont during interaction with host ; GO:0044149'.
subset: gosubset_prok
synonym: "positive regulation of growth of symbiont during interaction with host" RELATED [GOC:tb]
is_a: GO:0043902 ! positive regulation of multi-organism process
is_a: GO:0044144 ! modulation of growth of symbiont involved in interaction with host
is_a: GO:0045927 ! positive regulation of growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044116 ! growth of symbiont involved in interaction with host
relationship: positively_regulates GO:0044116 ! growth of symbiont involved in interaction with host
created_by: jane
creation_date: 2009-08-06T02:20:27Z

[Term]
id: GO:0044149
name: positive regulation of development of symbiont involved in interaction with host
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'positive regulation of growth or development of symbiont during interaction with host ; GO:0075339'. See also 'positive regulation of growth of symbiont during interaction with host ; GO:0044148'.
subset: gosubset_prok
synonym: "positive regulation of development of symbiont during interaction with host" RELATED [GOC:dph]
is_a: GO:0043902 ! positive regulation of multi-organism process
is_a: GO:0044145 ! modulation of development of symbiont involved in interaction with host
is_a: GO:0051094 ! positive regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044115 ! development of symbiont involved in interaction with host
relationship: positively_regulates GO:0044115 ! development of symbiont involved in interaction with host
created_by: jane
creation_date: 2009-08-06T02:20:55Z

[Term]
id: GO:0044150
name: development of organism on or near symbiont surface
namespace: biological_process
def: "The progression of an organism from an initial condition to a later condition, occurring on or near the exterior of its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc, GOC:jl]
subset: gosubset_prok
is_a: GO:0044152 ! development on or near surface of other organism involved in symbiotic interaction
created_by: jane
creation_date: 2009-08-06T03:15:52Z

[Term]
id: GO:0044151
name: growth of organism on or near symbiont surface
namespace: biological_process
def: "The increase in size or mass of an organism occurring on or near the exterior of its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc, GOC:jl]
comment: This term partially replaces the obsolete term 'growth or development of organism on or near symbiont surface ; GO:0051857'. See also 'development of organism on or near symbiont surface ; GO:0044150'.
subset: gosubset_prok
is_a: GO:0044153 ! growth on or near surface of other organism involved in symbiotic interaction
created_by: jane
creation_date: 2009-08-06T03:16:19Z

[Term]
id: GO:0044152
name: development on or near surface of other organism involved in symbiotic interaction
namespace: biological_process
def: "The progression of an organism from an initial condition to a later condition, occurring on or near the exterior of a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc, GOC:jl]
comment: This term partially replaces the obsolete term 'growth or development on or near surface of other organism during symbiotic interaction ; GO:0051827'. See also 'growth on or near surface of other organism during symbiotic interaction ; GO:0044153'.
subset: gosubset_prok
synonym: "development on or near surface of other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0044111 ! development involved in symbiotic interaction
created_by: jane
creation_date: 2009-08-06T03:25:28Z

[Term]
id: GO:0044153
name: growth on or near surface of other organism involved in symbiotic interaction
namespace: biological_process
def: "The increase in size or mass of an organism occurring on or near the exterior of a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc, GOC:jl]
comment: This term partially replaces the obsolete term 'growth or development on or near surface of other organism during symbiotic interaction ; GO:0051827'. See also 'development on or near surface of other organism during symbiotic interaction ; GO:0044152'.
subset: gosubset_prok
synonym: "growth on or near surface of other organism during symbiotic interaction" RELATED [GOC:tb]
is_a: GO:0044110 ! growth involved in symbiotic interaction
created_by: jane
creation_date: 2009-08-06T03:25:54Z

[Term]
id: GO:0044154
name: histone H3-K14 acetylation
namespace: biological_process
def: "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 14 of the histone." [GOC:jl, GOC:lb, PMID:17194708]
synonym: "histone H3 acetylation at K14" EXACT []
synonym: "histone H3K14 acetylation" EXACT []
is_a: GO:0043966 ! histone H3 acetylation
created_by: jane
creation_date: 2009-08-11T03:40:43Z

[Term]
id: GO:0044155
name: host caveola
namespace: cellular_component
def: "A small pit, depression, or invagination, such as any of the minute pits or incuppings of the host cell membrane formed during pinocytosis, that communicates with the outside of a host cell and extends inward, indenting the host cytoplasm and the host cell membrane. Such caveolae may be pinched off to form free vesicles within the host cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:rph]
is_a: GO:0033643 ! host cell part
relationship: part_of GO:0033644 ! host cell membrane
created_by: jane
creation_date: 2009-08-11T04:00:55Z

[Term]
id: GO:0044156
name: host cell junction
namespace: cellular_component
def: "A plasma membrane part that forms a specialized region of connection between two host cells or between a host cell and the host extracellular matrix. At a host cell junction, anchoring proteins extend through the host plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:rph]
is_a: GO:0033643 ! host cell part
relationship: part_of GO:0020002 ! host cell plasma membrane
created_by: jane
creation_date: 2009-08-11T04:04:50Z

[Term]
id: GO:0044157
name: host cell projection
namespace: cellular_component
def: "A prolongation or process extending from a host cell, e.g. a flagellum or axon." [GOC:rph]
subset: gosubset_prok
is_a: GO:0033643 ! host cell part
created_by: jane
creation_date: 2009-08-11T04:07:24Z

[Term]
id: GO:0044158
name: host cell wall
namespace: cellular_component
def: "The rigid or semi-rigid envelope lying outside the host cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan." [GOC:rph]
is_a: GO:0033643 ! host cell part
created_by: jane
creation_date: 2009-08-11T04:09:23Z

[Term]
id: GO:0044159
name: host thylakoid
namespace: cellular_component
def: "A membranous cellular structure within the host cell that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the host plasma membrane. In eukaryotic host cells they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation." [GOC:rph]
is_a: GO:0033655 ! host cell cytoplasm part
created_by: jane
creation_date: 2009-08-11T04:15:34Z

[Term]
id: GO:0044160
name: host thylakoid membrane
namespace: cellular_component
def: "The pigmented membrane of any host thylakoid." [GOC:rph]
is_a: GO:0033644 ! host cell membrane
is_a: GO:0033655 ! host cell cytoplasm part
relationship: part_of GO:0044159 ! host thylakoid
created_by: jane
creation_date: 2009-08-11T04:17:31Z

[Term]
id: GO:0044161
name: host cell cytoplasmic vesicle
namespace: cellular_component
def: "A vesicle formed of membrane or protein, found in the cytoplasm of a host cell." [GOC:rph]
is_a: GO:0033648 ! host intracellular membrane-bounded organelle
is_a: GO:0033655 ! host cell cytoplasm part
created_by: jane
creation_date: 2009-08-11T04:22:21Z

[Term]
id: GO:0044162
name: host cell cytoplasmic vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a host cell cytoplasmic vesicle." [GOC:rph]
is_a: GO:0033644 ! host cell membrane
is_a: GO:0033655 ! host cell cytoplasm part
relationship: part_of GO:0044161 ! host cell cytoplasmic vesicle
created_by: jane
creation_date: 2009-08-11T04:24:02Z

[Term]
id: GO:0044163
name: host cytoskeleton
namespace: cellular_component
def: "Any of the various filamentous elements that form the internal framework of host cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the host cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the host cell. The various elements of the host cytoskeleton not only serve in the maintenance of host cellular shape but also have roles in other host cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:rph]
is_a: GO:0033647 ! host intracellular organelle
created_by: jane
creation_date: 2009-08-11T04:27:04Z

[Term]
id: GO:0044164
name: host cell cytosol
namespace: cellular_component
def: "The part of the host cell cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:jl]
subset: gosubset_prok
synonym: "host cytosol" EXACT []
is_a: GO:0033655 ! host cell cytoplasm part
created_by: jane
creation_date: 2009-09-04T11:03:27Z

[Term]
id: GO:0044165
name: host cell endoplasmic reticulum
namespace: cellular_component
def: "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the host cell cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The host ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [GOC:jl]
subset: gosubset_prok
synonym: "host endoplasmic reticulum" EXACT []
is_a: GO:0033648 ! host intracellular membrane-bounded organelle
is_a: GO:0033655 ! host cell cytoplasm part
created_by: jane
creation_date: 2009-09-04T11:08:09Z

[Term]
id: GO:0044166
name: host cell endoplasmic reticulum lumen
namespace: cellular_component
def: "The volume enclosed by the membranes of the host cell endoplasmic reticulum." [GOC:jl]
subset: gosubset_prok
synonym: "host endoplasmic reticulum lumen" EXACT []
is_a: GO:0033655 ! host cell cytoplasm part
relationship: part_of GO:0044165 ! host cell endoplasmic reticulum
created_by: jane
creation_date: 2009-09-04T11:13:30Z

[Term]
id: GO:0044167
name: host cell endoplasmic reticulum membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the host cell endoplasmic reticulum." [GOC:jl]
subset: gosubset_prok
synonym: "host endoplasmic reticulum membrane" EXACT []
is_a: GO:0033644 ! host cell membrane
relationship: part_of GO:0033645 ! host cell endomembrane system
relationship: part_of GO:0044165 ! host cell endoplasmic reticulum
created_by: jane
creation_date: 2009-09-04T11:19:23Z

[Term]
id: GO:0044168
name: host cell rough endoplasmic reticulum
namespace: cellular_component
def: "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the host cell cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The host rough ER has ribosomes adhering to the outer surface." [GOC:jl]
subset: gosubset_prok
synonym: "host rough endoplasmic reticulum" EXACT []
is_a: GO:0044165 ! host cell endoplasmic reticulum
created_by: jane
creation_date: 2009-09-04T11:23:28Z

[Term]
id: GO:0044169
name: host cell rough endoplasmic reticulum membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the host cell rough endoplasmic reticulum." [GOC:jl]
subset: gosubset_prok
synonym: "host rough endoplasmic reticulum membrane" EXACT []
is_a: GO:0044167 ! host cell endoplasmic reticulum membrane
relationship: part_of GO:0044168 ! host cell rough endoplasmic reticulum
created_by: jane
creation_date: 2009-09-04T11:30:38Z

[Term]
id: GO:0044170
name: host cell smooth endoplasmic reticulum
namespace: cellular_component
def: "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the host cell cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The host smooth ER has no ribosomes adhering to the outer surface." [GOC:jl]
subset: gosubset_prok
synonym: "host smooth endoplasmic reticulum" EXACT []
is_a: GO:0044165 ! host cell endoplasmic reticulum
created_by: jane
creation_date: 2009-09-04T11:33:29Z

[Term]
id: GO:0044171
name: host cell smooth endoplasmic reticulum membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the host cell smooth endoplasmic reticulum." [GOC:jl]
subset: gosubset_prok
synonym: "host smooth endoplasmic reticulum membrane" EXACT []
is_a: GO:0044167 ! host cell endoplasmic reticulum membrane
relationship: part_of GO:0044170 ! host cell smooth endoplasmic reticulum
created_by: jane
creation_date: 2009-09-04T11:46:00Z

[Term]
id: GO:0044172
name: host cell endoplasmic reticulum-Golgi intermediate compartment
namespace: cellular_component
def: "A complex system of membrane-bounded compartments located between host cell endoplasmic reticulum (ER) and the host Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi transport." [GOC:jl, GOC:pr]
subset: gosubset_prok
synonym: "host cell ER-Golgi intermediate compartment" EXACT []
synonym: "host ER-Golgi intermediate compartment" EXACT []
is_a: GO:0033648 ! host intracellular membrane-bounded organelle
is_a: GO:0033655 ! host cell cytoplasm part
created_by: jane
creation_date: 2009-09-04T02:44:07Z

[Term]
id: GO:0044173
name: host cell endoplasmic reticulum-Golgi intermediate compartment membrane
namespace: cellular_component
def: "The lipid bilayer surrounding any of the compartments of the host cell ER-Golgi intermediate compartment system." [GOC:jl]
subset: gosubset_prok
synonym: "host cell ER-Golgi intermediate compartment membrane" EXACT []
synonym: "host endoplasmic reticulum-Golgi intermediate compartment membrane" EXACT []
synonym: "host ER-Golgi intermediate compartment membrane" EXACT []
is_a: GO:0033644 ! host cell membrane
relationship: part_of GO:0044172 ! host cell endoplasmic reticulum-Golgi intermediate compartment
created_by: jane
creation_date: 2009-09-04T02:46:13Z

[Term]
id: GO:0044174
name: host cell endosome
namespace: cellular_component
def: "A membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to host cell lysosomes for degradation." [GOC:jl]
subset: gosubset_prok
synonym: "host endosome" EXACT []
is_a: GO:0033648 ! host intracellular membrane-bounded organelle
is_a: GO:0033655 ! host cell cytoplasm part
created_by: jane
creation_date: 2009-09-04T03:02:01Z

[Term]
id: GO:0044175
name: host cell endosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a host cell endosome." [GOC:jl]
synonym: "host endosome membrane" EXACT []
is_a: GO:0033644 ! host cell membrane
relationship: part_of GO:0044174 ! host cell endosome
created_by: jane
creation_date: 2009-09-04T03:04:04Z

[Term]
id: GO:0044176
name: host cell filopodium
namespace: cellular_component
def: "Thin, stiff protrusion extended by the leading edge of a motile host cell such as a crawling fibroblast or amoeba, or an axonal growth cone; usually approximately 0.1 um wide, 5-10 um long, can be up to 50 um long in axon growth cones; contains a loose bundle of about 20 actin filaments oriented with their plus ends pointing outward." [GOC:jl]
subset: gosubset_prok
synonym: "host filopodium" EXACT []
is_a: GO:0044157 ! host cell projection
created_by: jane
creation_date: 2009-09-04T03:06:59Z

[Term]
id: GO:0044177
name: host cell Golgi apparatus
namespace: cellular_component
def: "A compound membranous cytoplasmic organelle of eukaryotic host cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack." [GOC:jl]
subset: gosubset_prok
synonym: "host Golgi apparatus" EXACT []
is_a: GO:0033655 ! host cell cytoplasm part
created_by: jane
creation_date: 2009-09-04T03:14:38Z

[Term]
id: GO:0044178
name: host cell Golgi membrane
namespace: cellular_component
def: "The lipid bilayer surrounding any of the compartments of the host cell Golgi apparatus." [GOC:jl]
subset: gosubset_prok
synonym: "host Golgi membrane" EXACT []
is_a: GO:0033644 ! host cell membrane
relationship: part_of GO:0033645 ! host cell endomembrane system
relationship: part_of GO:0044177 ! host cell Golgi apparatus
created_by: jane
creation_date: 2009-09-04T03:16:14Z

[Term]
id: GO:0044179
name: hemolysis in other organism
namespace: biological_process
def: "The cytolytic destruction of red blood cells, with the release of intracellular hemoglobin, in one organism by another." [GOC:jl]
subset: goslim_chembl
subset: gosubset_prok
synonym: "hemolysis of cells in other organism" EXACT [GOC:bf]
synonym: "hemolysis of erythrocytes in other organism" EXACT []
synonym: "hemolysis of RBCs in other organism" EXACT []
synonym: "hemolysis of red blood cells in other organism" EXACT []
is_a: GO:0051715 ! cytolysis in other organism
created_by: jane
creation_date: 2009-09-04T03:36:00Z

[Term]
id: GO:0044180
name: filamentous growth of a unicellular organism
namespace: biological_process
def: "The process in which a unicellular organism grows in a threadlike, filamentous shape." [GOC:mtg_cambridge_2009]
is_a: GO:0030447 ! filamentous growth
created_by: jane
creation_date: 2009-09-25T10:16:01Z

[Term]
id: GO:0044181
name: filamentous growth of a multicellular organism
namespace: biological_process
def: "The process in which a multicellular organism grows in a threadlike, filamentous shape." [GOC:mtg_cambridge_2009]
is_a: GO:0030447 ! filamentous growth
is_a: GO:0060560 ! developmental growth involved in morphogenesis
created_by: jane
creation_date: 2009-09-25T10:17:58Z

[Term]
id: GO:0044182
name: filamentous growth of a population of unicellular organisms
namespace: biological_process
def: "The process in which a group of unicellular organisms grow in a threadlike, filamentous shape." [GOC:mtg_cambridge_2009]
is_a: GO:0030447 ! filamentous growth
created_by: jane
creation_date: 2009-09-25T10:18:32Z

[Term]
id: GO:0044183
name: protein binding involved in protein folding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) that contributes to the process of protein folding." [GOC:mtg_cambridge_2009]
subset: goslim_chembl
synonym: "chaperone activity" BROAD []
is_a: GO:0005515 ! protein binding
intersection_of: GO:0005515 ! protein binding
intersection_of: part_of GO:0006457 ! protein folding
relationship: part_of GO:0006457 ! protein folding
created_by: jane
creation_date: 2009-09-25T11:33:48Z

[Term]
id: GO:0044184
name: host cell late endosome
namespace: cellular_component
def: "A prelysosomal endocytic organelle differentiated from host early endosomes by lower lumenal pH and different protein composition. Host late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044174 ! host cell endosome
created_by: jane
creation_date: 2009-10-15T02:58:34Z

[Term]
id: GO:0044185
name: host cell late endosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a host cell late endosome." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044175 ! host cell endosome membrane
relationship: part_of GO:0044184 ! host cell late endosome
created_by: jane
creation_date: 2009-10-15T03:00:39Z

[Term]
id: GO:0044186
name: host cell lipid particle
namespace: cellular_component
def: "Any particle of coalesced lipids in the cytoplasm of a host cell. May include associated proteins." [GOC:jl]
subset: gosubset_prok
is_a: GO:0033655 ! host cell cytoplasm part
created_by: jane
creation_date: 2009-10-15T03:05:06Z

[Term]
id: GO:0044187
name: host cell lysosome
namespace: cellular_component
def: "A small lytic vacuole that has cell cycle-independent morphology and is found in most host animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and host cell lysosomes have a great variety of morphologies and functions." [GOC:jl]
subset: gosubset_prok
is_a: GO:0033648 ! host intracellular membrane-bounded organelle
is_a: GO:0033655 ! host cell cytoplasm part
created_by: jane
creation_date: 2009-10-15T03:26:00Z

[Term]
id: GO:0044188
name: host cell lysosomal membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the host cell lysosome and separating its contents from the host cell cytoplasm." [GOC:jl]
subset: gosubset_prok
is_a: GO:0033644 ! host cell membrane
relationship: part_of GO:0044187 ! host cell lysosome
created_by: jane
creation_date: 2009-10-15T03:27:54Z

[Term]
id: GO:0044189
name: obsolete host cell microsome
namespace: cellular_component
def: "OBSOLETE: Any of the small, heterogeneous, artifactual, vesicular particles, 50-150 nm in diameter, that are formed when some eukaryotic host cells are homogenized and that sediment on centrifugation at 100000 g." [GOC:jl]
comment: This term was obsoleted because it refers to a cell fractionation experimental result and not a bona fide cellular component.
subset: gosubset_prok
synonym: "host cell microsomal membrane" EXACT []
synonym: "host cell microsome" EXACT []
is_obsolete: true
consider: GO:0033648
created_by: jane
creation_date: 2009-10-15T04:04:24Z

[Term]
id: GO:0044190
name: host cell mitochondrial envelope
namespace: cellular_component
def: "The double lipid bilayer enclosing the host cell mitochondrion and separating its contents from the host cell cytoplasm; includes the intermembrane space." [GOC:jl]
subset: gosubset_prok
is_a: GO:0033655 ! host cell cytoplasm part
relationship: part_of GO:0033650 ! host cell mitochondrion
created_by: jane
creation_date: 2009-10-15T04:12:55Z

[Term]
id: GO:0044191
name: host cell mitochondrial membrane
namespace: cellular_component
def: "Either of the lipid bilayers that surround the host cell mitochondrion and form the host cell mitochondrial envelope." [GOC:jl]
subset: gosubset_prok
is_a: GO:0033644 ! host cell membrane
relationship: part_of GO:0044190 ! host cell mitochondrial envelope
created_by: jane
creation_date: 2009-10-15T04:14:35Z

[Term]
id: GO:0044192
name: host cell mitochondrial inner membrane
namespace: cellular_component
def: "The inner, i.e. lumen-facing, lipid bilayer of the host cell mitochondrial envelope. It is highly folded to form cristae." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044191 ! host cell mitochondrial membrane
created_by: jane
creation_date: 2009-10-15T04:17:29Z

[Term]
id: GO:0044193
name: host cell mitochondrial outer membrane
namespace: cellular_component
def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the host cell mitochondrial envelope." [GOC:jl]
subset: gosubset_prok
is_a: GO:0039661 ! host organelle outer membrane
is_a: GO:0044191 ! host cell mitochondrial membrane
created_by: jane
creation_date: 2009-10-15T04:18:44Z

[Term]
id: GO:0044194
name: cytolytic granule
namespace: cellular_component
def: "A specialized secretory lysosome that is present in cells with cytolytic capability such as cytotoxic T lymphocytes and natural killer cells. Cytolytic granules mediate the storage and regulated excretion of lytic molecules for killing of target cells." [GOC:jl, PMID:11052265, PMID:12766758]
is_a: GO:0005764 ! lysosome
created_by: jane
creation_date: 2009-10-20T01:22:13Z

[Term]
id: GO:0044195
name: nucleoplasmic reticulum
namespace: cellular_component
def: "Long, dynamic tubular channels, formed by invagination of the nuclear envelope, that extend deep into the nucleoplasm. The channels have an underlying lamina and are implicated in functioning in signaling and transport." [GOC:jl, PMID:17959832, PMID:9024685]
synonym: "nuclear channels" EXACT []
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0005635 ! nuclear envelope
created_by: jane
creation_date: 2009-10-20T02:24:09Z

[Term]
id: GO:0044196
name: host cell nucleolus
namespace: cellular_component
def: "A small, dense body one or more of which are present in the nucleus of eukaryotic host cells." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044094 ! host cell nuclear part
created_by: jane
creation_date: 2009-10-20T02:37:07Z

[Term]
id: GO:0044197
name: Rel homology domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a Rel Homology Domain (RHD) of a protein. The RHD is found in a family of eukaryotic transcription factors, which includes NF-kappaB, Dorsal, Relish and NFAT." [InterPro:IPR011539, Wikipedia:Rel_homology_domain]
synonym: "RHD binding" EXACT []
is_a: GO:0019904 ! protein domain specific binding
created_by: jane
creation_date: 2009-10-20T03:57:48Z

[Term]
id: GO:0044198
name: zf-TRAF domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a TRAF-type zinc finger domain of a protein." [InterPro:IPR001293]
synonym: "TRAF-type zinc finger domain binding" EXACT []
synonym: "zinc finger TRAF-type domain binding" EXACT []
synonym: "zinc-finger-TRAF domain binding" EXACT []
is_a: GO:0019904 ! protein domain specific binding
created_by: jane
creation_date: 2009-10-20T04:09:08Z

[Term]
id: GO:0044199
name: host cell nuclear envelope
namespace: cellular_component
def: "The double lipid bilayer enclosing the host nucleus and separating its contents from the rest of the host cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044094 ! host cell nuclear part
relationship: part_of GO:0033645 ! host cell endomembrane system
created_by: jane
creation_date: 2009-10-21T10:56:11Z

[Term]
id: GO:0044200
name: host cell nuclear membrane
namespace: cellular_component
def: "Either of the lipid bilayers that surround the host nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:jl]
subset: gosubset_prok
is_a: GO:0033644 ! host cell membrane
relationship: part_of GO:0044199 ! host cell nuclear envelope
created_by: jane
creation_date: 2009-10-21T10:59:08Z

[Term]
id: GO:0044201
name: host cell nuclear inner membrane
namespace: cellular_component
def: "The inner, i.e. lumen-facing, lipid bilayer of the host nuclear envelope." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044200 ! host cell nuclear membrane
created_by: jane
creation_date: 2009-10-21T11:08:33Z

[Term]
id: GO:0044202
name: host cell nuclear outer membrane
namespace: cellular_component
def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the host nuclear envelope; continuous with the endoplasmic reticulum of the host cell and sometimes studded with ribosomes." [GOC:jl]
subset: gosubset_prok
is_a: GO:0039661 ! host organelle outer membrane
is_a: GO:0044200 ! host cell nuclear membrane
created_by: jane
creation_date: 2009-10-21T11:10:23Z

[Term]
id: GO:0044203
name: host cell nuclear lamina
namespace: cellular_component
def: "The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a host cell nucleus, composed of lamin filaments." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044094 ! host cell nuclear part
relationship: part_of GO:0044201 ! host cell nuclear inner membrane
created_by: jane
creation_date: 2009-10-21T11:11:56Z

[Term]
id: GO:0044204
name: host cell nuclear matrix
namespace: cellular_component
def: "The dense fibrillar network lying on the inner side of the host nuclear membrane." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044094 ! host cell nuclear part
created_by: jane
creation_date: 2009-10-21T11:15:36Z

[Term]
id: GO:0044205
name: 'de novo' UMP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate, starting with the synthesis of (S)-dihydroorotate from bicarbonate; UMP biosynthesis may either occur via reduction by quinone, NAD(+) or oxygen." [GOC:ecd, GOC:jl]
synonym: "'de novo' UMP biosynthesis" EXACT []
is_a: GO:0006222 ! UMP biosynthetic process
created_by: jane
creation_date: 2009-10-21T11:27:31Z

[Term]
id: GO:0044206
name: UMP salvage
namespace: biological_process
def: "Any process which produces UMP, uridine monophosphate, from derivatives of it (e.g. cytidine, uridine, cytosine) without de novo synthesis." [GOC:ecd, PMID:15096496]
synonym: "UMP biosynthesis via nucleoside salvage pathway" EXACT []
synonym: "UMP biosynthetic process via nucleoside salvage pathway" EXACT []
is_a: GO:0006222 ! UMP biosynthetic process
is_a: GO:0010138 ! pyrimidine ribonucleotide salvage
is_a: GO:0043097 ! pyrimidine nucleoside salvage
created_by: jane
creation_date: 2009-10-21T11:32:33Z

[Term]
id: GO:0044207
name: translation initiation ternary complex
namespace: cellular_component
def: "A ribonucleoprotein complex that contains aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator)." [GOC:jl]
synonym: "Met-tRNA/eIF2.GTP ternary complex" NARROW []
synonym: "translation initiation (ternary) complex" EXACT []
is_a: GO:0030529 ! intracellular ribonucleoprotein complex
is_a: GO:0044444 ! cytoplasmic part
created_by: jane
creation_date: 2009-10-22T02:38:55Z

[Term]
id: GO:0044208
name: 'de novo' AMP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from inosine 5'-monophosphate (IMP)." [GOC:ecd, PMID:10888601]
is_a: GO:0006167 ! AMP biosynthetic process
created_by: jane
creation_date: 2009-10-22T02:48:30Z

[Term]
id: GO:0044209
name: AMP salvage
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from derivatives of it (either adenine, ADP or adenosine 3',5'-bisphosphate) without de novo synthesis." [GOC:ecd, GOC:jl, PMID:8917457, PMID:9864350]
synonym: "adenosine monophosphate salvage" EXACT []
synonym: "AMP biosynthetic process via salvage pathway" EXACT []
is_a: GO:0006166 ! purine ribonucleoside salvage
is_a: GO:0006167 ! AMP biosynthetic process
is_a: GO:0032261 ! purine nucleotide salvage
created_by: jane
creation_date: 2009-10-22T02:52:11Z

[Term]
id: GO:0044210
name: 'de novo' CTP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cytidine 5'-triphosphate (CTP) from simpler components." [GOC:ecd, GOC:jl, PMID:11912132, PMID:18439916]
synonym: "'de novo' cytidine 5'-triphosphate biosynthetic process" EXACT []
is_a: GO:0006241 ! CTP biosynthetic process
created_by: jane
creation_date: 2009-10-22T03:22:34Z

[Term]
id: GO:0044211
name: CTP salvage
namespace: biological_process
def: "Any process which produces cytidine 5'-triphosphate (CTP) from derivatives of it, without de novo synthesis." [GOC:ecd, GOC:jl, PMID:10501935]
synonym: "CTP biosynthetic process via salvage pathway" EXACT []
synonym: "cytidine 5'-triphosphate salvage" EXACT []
is_a: GO:0006241 ! CTP biosynthetic process
is_a: GO:0010138 ! pyrimidine ribonucleotide salvage
is_a: GO:0043097 ! pyrimidine nucleoside salvage
created_by: jane
creation_date: 2009-10-22T03:24:04Z

[Term]
id: GO:0044212
name: transcription regulatory region DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:jl, GOC:txnOH, SO:0005836]
comment: The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding".
is_a: GO:0000975 ! regulatory region DNA binding
created_by: jane
creation_date: 2009-11-04T12:58:25Z

[Term]
id: GO:0044213
name: intronic transcription regulatory region DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an intronic DNA region that regulates the transcription of the transcript it is contained within." [GOC:ecd, GOC:txnOH]
is_a: GO:0044212 ! transcription regulatory region DNA binding
created_by: jane
creation_date: 2009-11-04T01:21:28Z

[Term]
id: GO:0044214
name: spanning component of plasma membrane
namespace: cellular_component
def: "The component of the plasma membrane consisting of gene products and protein complexes that have some part that spans both leaflets of the membrane." [GOC:ecd]
comment: Proteins that span the membrane but have the bulk on one side of the membrane may be additionally annotated with a term of the form integral to X side of the plasma membrane.
synonym: "fully spanning plasma membrane" EXACT []
synonym: "transmembrane" RELATED [GOC:mah]
is_a: GO:0005887 ! integral component of plasma membrane
is_a: GO:0089717 ! spanning component of membrane
intersection_of: GO:0089717 ! spanning component of membrane
intersection_of: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0005886 ! plasma membrane
created_by: jane
creation_date: 2009-11-04T01:50:57Z

[Term]
id: GO:0044215
name: other organism
namespace: cellular_component
def: "A secondary organism with which the first organism is interacting." [GOC:jl]
comment: We plan to obsolete this branch of GO and replace its usage in annotation with a system for multi-organism annotation.
is_a: GO:0005575 ! cellular_component
created_by: jane
creation_date: 2009-11-12T01:04:58Z

[Term]
id: GO:0044216
name: other organism cell
namespace: cellular_component
def: "A cell of a secondary organism with which the first organism is interacting." [GOC:jl]
is_a: GO:0044217 ! other organism part
created_by: jane
creation_date: 2009-11-12T01:17:06Z

[Term]
id: GO:0044217
name: other organism part
namespace: cellular_component
def: "Any constituent part of a secondary organism with which the first organism is interacting." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:0005575 ! cellular_component
intersection_of: GO:0005575 ! cellular_component
intersection_of: part_of GO:0044215 ! other organism
relationship: part_of GO:0044215 ! other organism
created_by: jane
creation_date: 2009-11-12T01:18:21Z

[Term]
id: GO:0044218
name: other organism cell membrane
namespace: cellular_component
def: "The cell membrane of a secondary organism with which the first organism is interacting." [GOC:jl]
synonym: "foreign membrane" RELATED []
is_a: GO:0044279 ! other organism membrane
relationship: part_of GO:0044216 ! other organism cell
created_by: jane
creation_date: 2009-11-12T02:37:44Z

[Term]
id: GO:0044219
name: host cell plasmodesma
namespace: cellular_component
def: "A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one host cell to that of an adjacent host cell." [GOC:rph]
is_a: GO:0044156 ! host cell junction
created_by: jane
creation_date: 2009-11-12T02:50:52Z

[Term]
id: GO:0044220
name: host cell perinuclear region of cytoplasm
namespace: cellular_component
def: "The host cell cytoplasm situated near, or occurring around, the host nucleus." [GOC:rph]
is_a: GO:0033655 ! host cell cytoplasm part
created_by: jane
creation_date: 2009-11-12T02:58:13Z

[Term]
id: GO:0044221
name: host cell synapse
namespace: cellular_component
def: "The junction between a nerve fiber of one host neuron and another host neuron or muscle fiber or glial cell; the site of interneuronal communication." [GOC:rph]
is_a: GO:0033643 ! host cell part
created_by: jane
creation_date: 2009-11-12T03:03:59Z

[Term]
id: GO:0044222
name: anammoxosome
namespace: cellular_component
def: "An intracytoplasmic membrane-bounded compartment in anaerobic ammonium oxidation (anammox) bacteria, is the site of anammox catabolism." [GOC:dh, PMID:17993524, PMID:19682260]
subset: gosubset_prok
is_a: GO:0043231 ! intracellular membrane-bounded organelle
is_a: GO:0044444 ! cytoplasmic part
created_by: jane
creation_date: 2009-11-12T04:03:24Z

[Term]
id: GO:0044223
name: pirellulosome
namespace: cellular_component
def: "A cytoplasmic structure found in bacterial phyla Planctomycetes and Verrucomicrobia containing a condensed nucleoid and ribosomes and surrounded by an intracytoplasmic membrane. It is surrounded by ribosome-free cytoplasm, in a compartment called the paryphoplasm." [GOC:dh, PMID:19133117]
subset: gosubset_prok
is_a: GO:0043231 ! intracellular membrane-bounded organelle
is_a: GO:0044444 ! cytoplasmic part
created_by: jane
creation_date: 2009-11-12T04:08:07Z

[Term]
id: GO:0044224
name: juxtaparanode region of axon
namespace: cellular_component
def: "A region of an axon near a node of Ranvier that is between the paranode and internode regions." [GOC:BHF, GOC:jl, PMID:10624965, PMID:14682359]
synonym: "juxta paranode axon" RELATED [NIF_Subcellular:sao1191319089]
synonym: "juxtaparanodal region" EXACT []
synonym: "juxtaparanode" EXACT []
xref: NIF_Subcellular:sao758620702
is_a: GO:0033267 ! axon part
relationship: part_of GO:0044304 ! main axon
created_by: jane
creation_date: 2009-11-13T12:57:36Z

[Term]
id: GO:0044225
name: apical pole of neuron
namespace: cellular_component
def: "Portion of a neuron cell soma closest to the point where the apical dendrite emerges." [NIF_Subcellular:sao1186862860]
xref: NIF_Subcellular:sao1186862860
is_a: GO:0060187 ! cell pole
is_a: GO:0097458 ! neuron part
relationship: part_of GO:0043025 ! neuronal cell body
created_by: jane
creation_date: 2009-11-13T03:49:14Z

[Term]
id: GO:0044226
name: basal pole of neuron
namespace: cellular_component
def: "Portion of a neuron cell soma closest to the point where the basilar dendrite emerges." [NIF_Subcellular:sao1186862860]
xref: NIF_Subcellular:sao1186862860
is_a: GO:0060187 ! cell pole
is_a: GO:0097458 ! neuron part
relationship: part_of GO:0043025 ! neuronal cell body
created_by: jane
creation_date: 2009-11-13T04:32:17Z

[Term]
id: GO:0044227
name: methane-oxidizing organelle
namespace: cellular_component
def: "A cytoplasmic, membrane-bounded compartment found within Methanotrophic bacteria that contains enzymes and electron transfer proteins for methane catabolism. This structure is analogous to the thylakoid of Cyanobacteria and the anammoxosome of anaerobic ammonium oxidation organisms." [GOC:dh]
subset: gosubset_prok
synonym: "methane-oxidizing compartment" EXACT []
synonym: "methanotroph intracytoplasmic membrane-bound compartment" EXACT []
is_a: GO:0043231 ! intracellular membrane-bounded organelle
is_a: GO:0044444 ! cytoplasmic part
created_by: jane
creation_date: 2009-11-17T02:13:52Z

[Term]
id: GO:0044228
name: host cell surface
namespace: cellular_component
def: "The external part of the host cell wall and/or host plasma membrane." [GOC:rph]
subset: gosubset_prok
is_a: GO:0033643 ! host cell part
created_by: jane
creation_date: 2009-12-03T01:49:45Z

[Term]
id: GO:0044229
name: host cell periplasmic space
namespace: cellular_component
def: "The region between the inner (cytoplasmic) and outer host membrane (Gram-negative Bacteria) or inner host membrane and host cell wall (Fungi)." [GOC:rph]
subset: gosubset_prok
is_a: GO:0033643 ! host cell part
created_by: jane
creation_date: 2009-12-03T01:52:31Z

[Term]
id: GO:0044230
name: host cell envelope
namespace: cellular_component
def: "An envelope that surrounds a bacterial host cell and includes the host cytoplasmic membrane and everything external, encompassing the host periplasmic space, host cell wall, and host outer membrane if present." [GOC:rph]
is_a: GO:0033643 ! host cell part
created_by: jane
creation_date: 2009-12-03T03:24:03Z

[Term]
id: GO:0044231
name: host cell presynaptic membrane
namespace: cellular_component
def: "A specialized area of membrane of the host axon terminal that faces the plasma membrane of the host neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many host synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane." [GOC:rph]
subset: gosubset_prok
synonym: "host cell pre-synaptic membrane" EXACT []
is_a: GO:0033644 ! host cell membrane
is_a: GO:0072556 ! other organism presynaptic membrane
relationship: part_of GO:0044221 ! host cell synapse
created_by: jane
creation_date: 2009-12-08T02:11:18Z

[Term]
id: GO:0044232
name: organelle membrane contact site
namespace: cellular_component
def: "A zone of apposition between the membranes of two organelles, structured by bridging complexes. Membrane contact sites (MCSs) are specialized for communication, including the efficient traffic of small molecules such as Ca2+ ions and lipids, as well as enzyme-substrate interactions." [GOC:jl, PMID:16806880]
synonym: "inter-organelle junction" EXACT []
synonym: "interorganelle junction" EXACT []
synonym: "MCS" EXACT []
is_a: GO:0044422 ! organelle part
created_by: jane
creation_date: 2010-01-07T03:44:20Z

[Term]
id: GO:0044233
name: ER-mitochondrion membrane contact site
namespace: cellular_component
def: "A zone of apposition between endoplasmic-reticulum and mitochondrial membranes, structured by bridging complexes. These contact sites are thought to facilitate inter-organelle calcium and phospholipid exchange." [GOC:jl, PMID:19556461]
synonym: "endoplasmic-reticulum-mitochondrion membrane contact site" EXACT []
is_a: GO:0044232 ! organelle membrane contact site
created_by: jane
creation_date: 2010-01-07T04:07:24Z

[Term]
id: GO:0044236
name: multicellular organism metabolic process
namespace: biological_process
def: "The chemical reactions and pathways in a single multicellular organism that occur at the tissue, organ, or organismal level. These processes, unlike cellular metabolism, can include transport of substances between cells when that transport is required." [GOC:go_curators]
synonym: "multicellular organismal metabolism" EXACT []
synonym: "single multicellular organismal metabolic process" EXACT []
is_a: GO:0044707 ! single-multicellular organism process
is_a: GO:0044710 ! single-organism metabolic process

[Term]
id: GO:0044237
name: cellular metabolic process
namespace: biological_process
def: "The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]
subset: goslim_pir
subset: gosubset_prok
synonym: "cellular metabolism" EXACT []
synonym: "intermediary metabolism" RELATED [GOC:mah]
is_a: GO:0008152 ! metabolic process
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0044238
name: primary metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators, http://www.metacyc.org]
subset: goslim_pir
subset: gosubset_prok
synonym: "primary metabolism" EXACT []
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0044239
name: salivary polysaccharide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of polysaccharides by salivary amylase. Salivary amylase is released by salivary glands, usually in the mouth." [GOC:jl, http://www.emc.maricopa.edu/]
synonym: "salivary polysaccharide breakdown" EXACT []
synonym: "salivary polysaccharide catabolism" EXACT []
synonym: "salivary polysaccharide degradation" EXACT []
is_a: GO:0044244 ! multicellular organismal polysaccharide catabolic process

[Term]
id: GO:0044240
name: multicellular organism lipid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lipids, occurring at the tissue, organ, or organismal level of a multicellular organism." [GOC:jl]
synonym: "organismal lipid breakdown" EXACT []
synonym: "organismal lipid catabolism" EXACT []
synonym: "organismal lipid degradation" EXACT []
is_a: GO:0016042 ! lipid catabolic process
is_a: GO:0044243 ! multicellular organism catabolic process
relationship: part_of GO:0044241 ! lipid digestion

[Term]
id: GO:0044241
name: lipid digestion
namespace: biological_process
def: "The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested lipids into components that may be easily absorbed and directed into metabolism." [GOC:go_curators]
xref: Reactome:REACT_104148 "Digestion of dietary lipid, Sus scrofa"
xref: Reactome:REACT_109891 "Digestion of dietary lipid, Danio rerio"
xref: Reactome:REACT_110159 "Digestion of dietary lipid, Taeniopygia guttata"
xref: Reactome:REACT_110543 "Digestion of dietary lipid, Rattus norvegicus"
xref: Reactome:REACT_29652 "Digestion of dietary lipid, Xenopus tropicalis"
xref: Reactome:REACT_29872 "Digestion of dietary lipid, Gallus gallus"
xref: Reactome:REACT_87351 "Digestion of dietary lipid, Bos taurus"
xref: Reactome:REACT_90828 "Digestion of dietary lipid, Canis familiaris"
xref: Reactome:REACT_9518 "Digestion of dietary lipid, Homo sapiens"
xref: Reactome:REACT_97542 "Digestion of dietary lipid, Mus musculus"
is_a: GO:0007586 ! digestion

[Term]
id: GO:0044242
name: cellular lipid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lipids, as carried out by individual cells." [GOC:jl]
subset: gosubset_prok
synonym: "cellular lipid breakdown" EXACT []
synonym: "cellular lipid catabolism" EXACT []
synonym: "cellular lipid degradation" EXACT []
is_a: GO:0016042 ! lipid catabolic process
is_a: GO:0044248 ! cellular catabolic process
is_a: GO:0044255 ! cellular lipid metabolic process

[Term]
id: GO:0044243
name: multicellular organism catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of substances in multicellular organisms that occur at the tissue, organ, or organismal level. These processes, unlike cellular metabolism, can include transport of substances between cells when that transport is required." [GOC:go_curators]
synonym: "organismal breakdown" EXACT []
synonym: "organismal catabolism" EXACT []
synonym: "organismal degradation" EXACT []
is_a: GO:0044236 ! multicellular organism metabolic process

[Term]
id: GO:0044244
name: multicellular organismal polysaccharide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of polysaccharides, occurring at the tissue, organ, or organismal level of a multicellular organism." [GOC:jl]
synonym: "organismal polysaccharide breakdown" EXACT []
synonym: "organismal polysaccharide catabolism" EXACT []
synonym: "organismal polysaccharide degradation" EXACT []
is_a: GO:0000272 ! polysaccharide catabolic process
is_a: GO:0044263 ! multicellular organismal polysaccharide metabolic process
is_a: GO:0044276 ! multicellular organism carbohydrate catabolic process
relationship: part_of GO:0044245 ! polysaccharide digestion

[Term]
id: GO:0044245
name: polysaccharide digestion
namespace: biological_process
def: "The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested polysaccharides into components that may be easily absorbed and directed into metabolism." [GOC:go_curators]
xref: Reactome:REACT_106174 "Digestion of dietary carbohydrate, Oryza sativa"
xref: Reactome:REACT_107149 "Digestion of dietary carbohydrate, Dictyostelium discoideum"
xref: Reactome:REACT_110811 "Digestion of dietary carbohydrate, Mus musculus"
xref: Reactome:REACT_114891 "Digestion of dietary carbohydrate, Escherichia coli"
xref: Reactome:REACT_30064 "Digestion of dietary carbohydrate, Canis familiaris"
xref: Reactome:REACT_30780 "Digestion of dietary carbohydrate, Sus scrofa"
xref: Reactome:REACT_32365 "Digestion of dietary carbohydrate, Rattus norvegicus"
xref: Reactome:REACT_33100 "Digestion of dietary carbohydrate, Caenorhabditis elegans"
xref: Reactome:REACT_33878 "Digestion of dietary carbohydrate, Schizosaccharomyces pombe"
xref: Reactome:REACT_81470 "Digestion of dietary carbohydrate, Bos taurus"
xref: Reactome:REACT_92817 "Digestion of dietary carbohydrate, Gallus gallus"
xref: Reactome:REACT_94006 "Digestion of dietary carbohydrate, Xenopus tropicalis"
xref: Reactome:REACT_9472 "Digestion of dietary carbohydrate, Homo sapiens"
xref: Reactome:REACT_94809 "Digestion of dietary carbohydrate, Taeniopygia guttata"
xref: Reactome:REACT_96607 "Digestion of dietary carbohydrate, Drosophila melanogaster"
xref: Reactome:REACT_97489 "Digestion of dietary carbohydrate, Arabidopsis thaliana"
xref: Reactome:REACT_97998 "Digestion of dietary carbohydrate, Danio rerio"
is_a: GO:0007586 ! digestion

[Term]
id: GO:0044246
name: regulation of multicellular organismal metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chemical reactions and pathways in multicellular organisms that occur at the tissue, organ, or organismal level." [GOC:go_curators, GOC:tb]
synonym: "regulation of organismal metabolic process" EXACT [GOC:tb]
synonym: "regulation of organismal metabolism" EXACT []
is_a: GO:0019222 ! regulation of metabolic process
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044236 ! multicellular organism metabolic process
relationship: regulates GO:0044236 ! multicellular organism metabolic process

[Term]
id: GO:0044247
name: cellular polysaccharide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of many (typically more than 10) monosaccharide residues linked glycosidically, as carried out by individual cells." [CHEBI:18154, GOC:jl]
subset: gosubset_prok
synonym: "cellular polysaccharide breakdown" EXACT []
synonym: "cellular polysaccharide catabolism" EXACT []
synonym: "cellular polysaccharide degradation" EXACT []
is_a: GO:0000272 ! polysaccharide catabolic process
is_a: GO:0044264 ! cellular polysaccharide metabolic process
is_a: GO:0044275 ! cellular carbohydrate catabolic process

[Term]
id: GO:0044248
name: cellular catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:jl]
subset: gosubset_prok
synonym: "cellular breakdown" EXACT []
synonym: "cellular catabolism" EXACT []
synonym: "cellular degradation" EXACT []
is_a: GO:0009056 ! catabolic process
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0044249
name: cellular biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:jl]
subset: gosubset_prok
synonym: "cellular anabolism" EXACT []
synonym: "cellular biosynthesis" EXACT []
synonym: "cellular formation" EXACT []
synonym: "cellular synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0044250
name: negative regulation of metabolic activity involved in hibernation
namespace: biological_process
def: "The slowing of metabolic processes to very low levels in order to conserve energy as a part of hibernation." [GOC:jl, Wikipedia:Hibernation]
synonym: "down regulation of metabolic activity during hibernation" RELATED []
synonym: "down-regulation of metabolic activity during hibernation" RELATED []
synonym: "downregulation of metabolic activity during hibernation" RELATED []
synonym: "inhibition of metabolic activity during hibernation" NARROW []
synonym: "negative regulation of metabolic activity during hibernation" RELATED [GOC:tb]
is_a: GO:0044252 ! negative regulation of multicellular organismal metabolic process
relationship: part_of GO:0042750 ! hibernation

[Term]
id: GO:0044251
name: protein catabolic process by pepsin
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein by pepsin in the stomach. Pepsin is generated from its precursor pepsinogen, which is activated by hydrolchloric acid (gastric acid)." [GOC:jl, http://www.emc.maricopa.edu/]
synonym: "protein breakdown by pepsin" EXACT []
synonym: "protein degradation by pepsin" EXACT []
is_a: GO:0044254 ! multicellular organismal protein catabolic process

[Term]
id: GO:0044252
name: negative regulation of multicellular organismal metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces frequency, rate or extent of chemical reactions and pathways in multicellular organisms that occur at the tissue, organ, or organismal level." [GOC:jl]
synonym: "down regulation of organismal metabolic process" EXACT []
synonym: "down-regulation of organismal metabolic process" EXACT []
synonym: "downregulation of organismal metabolic process" EXACT []
synonym: "inhibition of organismal metabolic process" NARROW []
synonym: "negative regulation of organismal metabolism" EXACT []
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0044246 ! regulation of multicellular organismal metabolic process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044236 ! multicellular organism metabolic process
relationship: negatively_regulates GO:0044236 ! multicellular organism metabolic process

[Term]
id: GO:0044253
name: positive regulation of multicellular organismal metabolic process
namespace: biological_process
def: "Any process that activates or increases frequency, rate or extent of chemical reactions and pathways in multicellular organisms that occur at the tissue, organ, or organismal level." [GOC:jl]
synonym: "activation of organismal metabolic process" NARROW []
synonym: "positive regulation of organismal metabolism" EXACT []
synonym: "stimulation of organismal metabolic process" NARROW []
synonym: "up regulation of organismal metabolic process" EXACT []
synonym: "up-regulation of organismal metabolic process" EXACT []
synonym: "upregulation of organismal metabolic process" EXACT []
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0044246 ! regulation of multicellular organismal metabolic process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044236 ! multicellular organism metabolic process
relationship: positively_regulates GO:0044236 ! multicellular organism metabolic process

[Term]
id: GO:0044254
name: multicellular organismal protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein in a multicellular organism, occurring at the tissue, organ, or organismal level." [GOC:jl]
synonym: "organismal protein breakdown" EXACT []
synonym: "organismal protein catabolism" EXACT []
synonym: "organismal protein degradation" EXACT []
is_a: GO:0030163 ! protein catabolic process
is_a: GO:0044243 ! multicellular organism catabolic process
is_a: GO:0044266 ! multicellular organismal macromolecule catabolic process
is_a: GO:0044268 ! multicellular organismal protein metabolic process
is_a: GO:0044712 ! single-organism catabolic process
relationship: part_of GO:0044256 ! protein digestion

[Term]
id: GO:0044255
name: cellular lipid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lipids, as carried out by individual cells." [GOC:jl]
subset: goslim_pir
subset: gosubset_prok
synonym: "cellular lipid metabolism" EXACT []
xref: Reactome:REACT_100469 "Fatty acid, triacylglycerol, and ketone body metabolism, Rattus norvegicus"
xref: Reactome:REACT_101288 "Peroxisomal lipid metabolism, Bos taurus"
xref: Reactome:REACT_101329 "Fatty acid, triacylglycerol, and ketone body metabolism, Mus musculus"
xref: Reactome:REACT_102412 "Fatty acid, triacylglycerol, and ketone body metabolism, Canis familiaris"
xref: Reactome:REACT_106581 "Peroxisomal lipid metabolism, Rattus norvegicus"
xref: Reactome:REACT_106990 "Fatty acid, triacylglycerol, and ketone body metabolism, Xenopus tropicalis"
xref: Reactome:REACT_107435 "Peroxisomal lipid metabolism, Danio rerio"
xref: Reactome:REACT_108484 "Peroxisomal lipid metabolism, Dictyostelium discoideum"
xref: Reactome:REACT_112736 "Peroxisomal lipid metabolism, Plasmodium falciparum"
xref: Reactome:REACT_16957 "Peroxisomal lipid metabolism, Homo sapiens"
xref: Reactome:REACT_22279 "Fatty acid, triacylglycerol, and ketone body metabolism, Homo sapiens"
xref: Reactome:REACT_28392 "Fatty acid, triacylglycerol, and ketone body metabolism, Arabidopsis thaliana"
xref: Reactome:REACT_28564 "Peroxisomal lipid metabolism, Canis familiaris"
xref: Reactome:REACT_28948 "Peroxisomal lipid metabolism, Mus musculus"
xref: Reactome:REACT_29328 "Fatty acid, triacylglycerol, and ketone body metabolism, Mycobacterium tuberculosis"
xref: Reactome:REACT_31891 "Fatty acid, triacylglycerol, and ketone body metabolism, Caenorhabditis elegans"
xref: Reactome:REACT_32011 "Fatty acid, triacylglycerol, and ketone body metabolism, Danio rerio"
xref: Reactome:REACT_32998 "Peroxisomal lipid metabolism, Schizosaccharomyces pombe"
xref: Reactome:REACT_34149 "Fatty acid, triacylglycerol, and ketone body metabolism, Taeniopygia guttata"
xref: Reactome:REACT_79191 "Peroxisomal lipid metabolism, Drosophila melanogaster"
xref: Reactome:REACT_79497 "Peroxisomal lipid metabolism, Taeniopygia guttata"
xref: Reactome:REACT_81034 "Peroxisomal lipid metabolism, Gallus gallus"
xref: Reactome:REACT_81319 "Peroxisomal lipid metabolism, Arabidopsis thaliana"
xref: Reactome:REACT_82818 "Peroxisomal lipid metabolism, Caenorhabditis elegans"
xref: Reactome:REACT_83359 "Fatty acid, triacylglycerol, and ketone body metabolism, Sus scrofa"
xref: Reactome:REACT_84205 "Fatty acid, triacylglycerol, and ketone body metabolism, Gallus gallus"
xref: Reactome:REACT_84404 "Peroxisomal lipid metabolism, Mycobacterium tuberculosis"
xref: Reactome:REACT_86890 "Fatty acid, triacylglycerol, and ketone body metabolism, Staphylococcus aureus N315"
xref: Reactome:REACT_87163 "Peroxisomal lipid metabolism, Staphylococcus aureus N315"
xref: Reactome:REACT_87905 "Fatty acid, triacylglycerol, and ketone body metabolism, Drosophila melanogaster"
xref: Reactome:REACT_89268 "Fatty acid, triacylglycerol, and ketone body metabolism, Dictyostelium discoideum"
xref: Reactome:REACT_90141 "Fatty acid, triacylglycerol, and ketone body metabolism, Plasmodium falciparum"
xref: Reactome:REACT_92117 "Peroxisomal lipid metabolism, Escherichia coli"
xref: Reactome:REACT_93461 "Fatty acid, triacylglycerol, and ketone body metabolism, Bos taurus"
xref: Reactome:REACT_94360 "Peroxisomal lipid metabolism, Saccharomyces cerevisiae"
xref: Reactome:REACT_96855 "Fatty acid, triacylglycerol, and ketone body metabolism, Escherichia coli"
xref: Reactome:REACT_97999 "Fatty acid, triacylglycerol, and ketone body metabolism, Schizosaccharomyces pombe"
xref: Reactome:REACT_98520 "Peroxisomal lipid metabolism, Oryza sativa"
xref: Reactome:REACT_98981 "Fatty acid, triacylglycerol, and ketone body metabolism, Saccharomyces cerevisiae"
xref: Reactome:REACT_99720 "Fatty acid, triacylglycerol, and ketone body metabolism, Oryza sativa"
xref: Reactome:REACT_99861 "Peroxisomal lipid metabolism, Xenopus tropicalis"
xref: Reactome:REACT_99881 "Peroxisomal lipid metabolism, Sus scrofa"
is_a: GO:0006629 ! lipid metabolic process
is_a: GO:0044237 ! cellular metabolic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0044256
name: protein digestion
namespace: biological_process
def: "The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested proteins into components that may be easily absorbed and directed into metabolism." [GOC:go_curators]
is_a: GO:0007586 ! digestion

[Term]
id: GO:0044257
name: cellular protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:jl]
subset: gosubset_prok
synonym: "cellular protein breakdown" EXACT []
synonym: "cellular protein catabolism" EXACT []
synonym: "cellular protein degradation" EXACT []
xref: Reactome:REACT_104979 "Degradation of newly synthesized ApoB-48, Rattus norvegicus"
xref: Reactome:REACT_105668 "Degradation of newly synthesized ApoB-48, Mus musculus"
xref: Reactome:REACT_107565 "Degradation of newly synthesized ApoB-48, Xenopus tropicalis"
xref: Reactome:REACT_28414 "Degradation of newly synthesized ApoB-48, Canis familiaris"
xref: Reactome:REACT_30520 "Degradation of newly synthesized ApoB-48, Gallus gallus"
xref: Reactome:REACT_34532 "Degradation of newly synthesized ApoB-48, Taeniopygia guttata"
xref: Reactome:REACT_6829 "Degradation of newly synthesized ApoB-48, Homo sapiens"
xref: Reactome:REACT_77105 "Degradation of newly synthesized ApoB-48, Danio rerio"
xref: Reactome:REACT_79506 "Degradation of newly synthesized ApoB-48, Sus scrofa"
xref: Reactome:REACT_86672 "Degradation of newly synthesized ApoB-48, Bos taurus"
is_a: GO:0030163 ! protein catabolic process
is_a: GO:0044265 ! cellular macromolecule catabolic process
is_a: GO:0044267 ! cellular protein metabolic process

[Term]
id: GO:0044258
name: intestinal lipid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown into fatty acids and monoglycerides of lipids in the small intestine. Lipids are broken down by lipases released by the pancreas." [GOC:jl, http://www.emc.maricopa.edu/]
synonym: "intestinal lipid breakdown" EXACT []
synonym: "intestinal lipid catabolism" EXACT []
synonym: "intestinal lipid degradation" EXACT []
is_a: GO:0044240 ! multicellular organism lipid catabolic process

[Term]
id: GO:0044259
name: multicellular organismal macromolecule metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving macromolecules, large molecules including proteins, nucleic acids and carbohydrates, in multicellular organisms occurring at the tissue, organ, or organismal level." [GOC:jl]
synonym: "organismal macromolecule metabolism" EXACT []
is_a: GO:0043170 ! macromolecule metabolic process
is_a: GO:0044236 ! multicellular organism metabolic process

[Term]
id: GO:0044260
name: cellular macromolecule metabolic process
namespace: biological_process
alt_id: GO:0034960
def: "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells." [CHEBI:33694, GOC:mah]
subset: gosubset_prok
synonym: "cellular biopolymer metabolic process" EXACT [GOC:mtg_chebi_dec09]
synonym: "cellular macromolecule metabolism" EXACT []
is_a: GO:0043170 ! macromolecule metabolic process
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0044261
name: multicellular organism carbohydrate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, in a single multicellular organism, occurring at the tissue, organ, or organismal level." [GOC:jl]
synonym: "organismal carbohydrate metabolism" EXACT []
synonym: "single multicellular organismal carbohydrate metabolic process" EXACT []
is_a: GO:0044259 ! multicellular organismal macromolecule metabolic process
is_a: GO:0044723 ! single-organism carbohydrate metabolic process

[Term]
id: GO:0044262
name: cellular carbohydrate metabolic process
namespace: biological_process
alt_id: GO:0006092
def: "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:jl]
subset: gosubset_prok
synonym: "cellular carbohydrate metabolism" EXACT []
synonym: "main pathways of carbohydrate metabolic process" NARROW []
synonym: "main pathways of carbohydrate metabolism" NARROW []
is_a: GO:0005975 ! carbohydrate metabolic process
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0044263
name: multicellular organismal polysaccharide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages, in multicellular organisms that occur at the tissue, organ, or organismal level." [GOC:jl]
synonym: "organismal glycan metabolic process" EXACT []
synonym: "organismal glycan metabolism" EXACT []
synonym: "organismal polysaccharide metabolism" EXACT []
is_a: GO:0005976 ! polysaccharide metabolic process
is_a: GO:0044261 ! multicellular organism carbohydrate metabolic process

[Term]
id: GO:0044264
name: cellular polysaccharide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages, as carried out by individual cells." [GOC:jl]
subset: gosubset_prok
synonym: "cellular glycan metabolic process" EXACT []
synonym: "cellular glycan metabolism" EXACT []
synonym: "cellular polysaccharide metabolism" EXACT []
is_a: GO:0005976 ! polysaccharide metabolic process
is_a: GO:0044260 ! cellular macromolecule metabolic process
is_a: GO:0044262 ! cellular carbohydrate metabolic process

[Term]
id: GO:0044265
name: cellular macromolecule catabolic process
namespace: biological_process
alt_id: GO:0034962
def: "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any large molecule including proteins, nucleic acids and carbohydrates, as carried out by individual cells." [CHEBI:33694, GOC:jl]
subset: gosubset_prok
synonym: "cellular biopolymer catabolic process" EXACT [GOC:mtg_chebi_dec09]
synonym: "cellular macromolecule breakdown" EXACT []
synonym: "cellular macromolecule catabolism" EXACT []
synonym: "cellular macromolecule degradation" EXACT []
is_a: GO:0009057 ! macromolecule catabolic process
is_a: GO:0044248 ! cellular catabolic process
is_a: GO:0044260 ! cellular macromolecule metabolic process

[Term]
id: GO:0044266
name: multicellular organismal macromolecule catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any large molecule including proteins, nucleic acids and carbohydrates, in multicellular organisms occurring at the tissue, organ, or organismal level." [GOC:jl]
synonym: "organismal macromolecule breakdown" EXACT []
synonym: "organismal macromolecule catabolism" EXACT []
synonym: "organismal macromolecule degradation" EXACT []
is_a: GO:0009057 ! macromolecule catabolic process

[Term]
id: GO:0044267
name: cellular protein metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification." [GOC:jl]
subset: gosubset_prok
synonym: "cellular protein metabolism" EXACT []
xref: Reactome:REACT_101554 "Metabolism of proteins, Gallus gallus"
xref: Reactome:REACT_102155 "Metabolism of proteins, Arabidopsis thaliana"
xref: Reactome:REACT_105825 "Metabolism of proteins, Dictyostelium discoideum"
xref: Reactome:REACT_106151 "Metabolism of proteins, Xenopus tropicalis"
xref: Reactome:REACT_108005 "Metabolism of proteins, Bos taurus"
xref: Reactome:REACT_109022 "Metabolism of proteins, Schizosaccharomyces pombe"
xref: Reactome:REACT_17015 "Metabolism of proteins, Homo sapiens"
xref: Reactome:REACT_32904 "Metabolism of proteins, Canis familiaris"
xref: Reactome:REACT_34473 "Metabolism of proteins, Taeniopygia guttata"
xref: Reactome:REACT_80561 "Metabolism of proteins, Escherichia coli"
xref: Reactome:REACT_81994 "Metabolism of proteins, Sus scrofa"
xref: Reactome:REACT_82523 "Metabolism of proteins, Danio rerio"
xref: Reactome:REACT_85873 "Metabolism of proteins, Saccharomyces cerevisiae"
xref: Reactome:REACT_86658 "Metabolism of proteins, Drosophila melanogaster"
xref: Reactome:REACT_89852 "Metabolism of proteins, Rattus norvegicus"
xref: Reactome:REACT_91052 "Metabolism of proteins, Caenorhabditis elegans"
xref: Reactome:REACT_93132 "Metabolism of proteins, Mus musculus"
xref: Reactome:REACT_96466 "Metabolism of proteins, Plasmodium falciparum"
xref: Reactome:REACT_99179 "Metabolism of proteins, Oryza sativa"
is_a: GO:0019538 ! protein metabolic process
is_a: GO:0044260 ! cellular macromolecule metabolic process

[Term]
id: GO:0044268
name: multicellular organismal protein metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a specific protein, rather than of proteins in general, in multicellular organisms occurring at the tissue, organ, or organismal level." [GOC:jl]
synonym: "organismal protein metabolism" EXACT []
is_a: GO:0019538 ! protein metabolic process
is_a: GO:0044259 ! multicellular organismal macromolecule metabolic process

[Term]
id: GO:0044269
name: glycerol ether catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol." [GOC:jl]
subset: gosubset_prok
synonym: "glycerol ether breakdown" EXACT []
synonym: "glycerol ether catabolism" EXACT []
synonym: "glycerol ether degradation" EXACT []
is_a: GO:0006662 ! glycerol ether metabolic process
is_a: GO:0044248 ! cellular catabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:1901502 ! ether catabolic process

[Term]
id: GO:0044270
name: cellular nitrogen compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of organic and inorganic nitrogenous compounds." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "nitrogen compound breakdown" BROAD []
synonym: "nitrogen compound catabolism" BROAD []
synonym: "nitrogen compound degradation" BROAD []
is_a: GO:0034641 ! cellular nitrogen compound metabolic process
is_a: GO:0044248 ! cellular catabolic process

[Term]
id: GO:0044271
name: cellular nitrogen compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "nitrogen compound anabolism" BROAD []
synonym: "nitrogen compound biosynthesis" BROAD []
synonym: "nitrogen compound formation" BROAD []
synonym: "nitrogen compound synthesis" BROAD []
is_a: GO:0034641 ! cellular nitrogen compound metabolic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0044272
name: sulfur compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:jl]
subset: gosubset_prok
synonym: "sulfur biosynthesis" NARROW []
synonym: "sulfur biosynthetic process" NARROW []
synonym: "sulfur compound anabolism" EXACT []
synonym: "sulfur compound biosynthesis" EXACT []
synonym: "sulfur compound formation" EXACT []
synonym: "sulfur compound synthesis" EXACT []
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0044273
name: sulfur compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:jl]
subset: gosubset_prok
synonym: "sulfur catabolic process" NARROW []
synonym: "sulfur catabolism" NARROW []
synonym: "sulfur compound breakdown" EXACT []
synonym: "sulfur compound catabolism" EXACT []
synonym: "sulfur compound degradation" EXACT []
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0044248 ! cellular catabolic process

[Term]
id: GO:0044274
name: multicellular organism biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of substances in multicellular organisms, occurring at the tissue, organ, or organismal level." [GOC:jl]
synonym: "organismal anabolism" EXACT []
synonym: "organismal biosynthesis" EXACT []
synonym: "organismal formation" EXACT []
synonym: "organismal synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process

[Term]
id: GO:0044275
name: cellular carbohydrate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:jl]
subset: gosubset_prok
synonym: "cellular carbohydrate breakdown" EXACT []
synonym: "cellular carbohydrate catabolism" EXACT []
synonym: "cellular carbohydrate degradation" EXACT []
is_a: GO:0016052 ! carbohydrate catabolic process
is_a: GO:0044248 ! cellular catabolic process
is_a: GO:0044262 ! cellular carbohydrate metabolic process

[Term]
id: GO:0044276
name: multicellular organism carbohydrate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, in a single multicellular organism occurring at the tissue, organ, or organismal level." [GOC:jl]
synonym: "organismal carbohydrate breakdown" EXACT []
synonym: "organismal carbohydrate catabolism" EXACT []
synonym: "organismal carbohydrate degradation" EXACT []
synonym: "single multicellular organismal carbohydrate catabolic process" EXACT []
is_a: GO:0044243 ! multicellular organism catabolic process
is_a: GO:0044261 ! multicellular organism carbohydrate metabolic process
is_a: GO:0044266 ! multicellular organismal macromolecule catabolic process
is_a: GO:0044724 ! single-organism carbohydrate catabolic process

[Term]
id: GO:0044277
name: cell wall disassembly
namespace: biological_process
alt_id: GO:0060871
def: "A process that results in the breakdown of the cell wall." [GOC:jl]
subset: gosubset_prok
synonym: "cellular cell wall disassembly" EXACT []
is_a: GO:0022411 ! cellular component disassembly
is_a: GO:0071555 ! cell wall organization
created_by: jane
creation_date: 2010-01-14T02:00:34Z

[Term]
id: GO:0044278
name: cell wall disruption in other organism
namespace: biological_process
def: "A process carried out by an organism that results in the breakdown of the cell wall of a second organism." [GOC:jl]
is_a: GO:0035821 ! modification of morphology or physiology of other organism
created_by: jane
creation_date: 2010-01-14T02:01:48Z

[Term]
id: GO:0044279
name: other organism membrane
namespace: cellular_component
def: "A membrane of a secondary organism with which the first organism is interacting." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044217 ! other organism part
created_by: jane
creation_date: 2010-01-14T02:13:08Z

[Term]
id: GO:0044280
name: subplasmalemmal coating
namespace: cellular_component
def: "Electron dense material observed coating the cytoplasmic face of the plasma membrane in certain regions of a neuron, e.g., the axon initial segment; the nodal membrane at the Node of Ranvier." [NIF_Subcellular:sao1938587839]
xref: NIF_Subcellular:sao1938587839
is_a: GO:0044424 ! intracellular part
is_a: GO:0044459 ! plasma membrane part
is_a: GO:0097458 ! neuron part
relationship: part_of GO:0031234 ! extrinsic component of cytoplasmic side of plasma membrane
created_by: jane
creation_date: 2010-01-14T03:58:38Z

[Term]
id: GO:0044281
name: small molecule metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw]
comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides.
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
synonym: "small molecule metabolism" EXACT []
xref: Reactome:REACT_111217 "Metabolism, Homo sapiens"
xref: Reactome:REACT_112077 "Metabolism, Xenopus tropicalis"
xref: Reactome:REACT_112140 "Metabolism, Dictyostelium discoideum"
xref: Reactome:REACT_112621 "Metabolism, Mus musculus"
xref: Reactome:REACT_112912 "Metabolism, Arabidopsis thaliana"
xref: Reactome:REACT_113131 "Metabolism, Schizosaccharomyces pombe"
xref: Reactome:REACT_113305 "Metabolism, Canis familiaris"
xref: Reactome:REACT_113457 "Metabolism, Mycobacterium tuberculosis"
xref: Reactome:REACT_113568 "Metabolism, Rattus norvegicus"
xref: Reactome:REACT_113610 "Metabolism, Caenorhabditis elegans"
xref: Reactome:REACT_113934 "Metabolism, Escherichia coli"
xref: Reactome:REACT_114081 "Metabolism, Gallus gallus"
xref: Reactome:REACT_114137 "Metabolism, Sus scrofa"
xref: Reactome:REACT_114421 "Metabolism, Saccharomyces cerevisiae"
xref: Reactome:REACT_114473 "Metabolism, Danio rerio"
xref: Reactome:REACT_114495 "Metabolism, Staphylococcus aureus N315"
xref: Reactome:REACT_114668 "Metabolism, Plasmodium falciparum"
xref: Reactome:REACT_114983 "Metabolism, Drosophila melanogaster"
xref: Reactome:REACT_115063 "Metabolism, Taeniopygia guttata"
xref: Reactome:REACT_115388 "Metabolism, Oryza sativa"
xref: Reactome:REACT_115420 "Metabolism, Bos taurus"
xref: Reactome:REACT_115655 "Metabolism, Gallus gallus"
is_a: GO:0044710 ! single-organism metabolic process
created_by: jane
creation_date: 2010-01-26T12:05:20Z

[Term]
id: GO:0044282
name: small molecule catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:vw]
comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides.
synonym: "small molecule catabolism" EXACT []
is_a: GO:0044281 ! small molecule metabolic process
is_a: GO:0044712 ! single-organism catabolic process
created_by: jane
creation_date: 2010-01-26T12:06:10Z

[Term]
id: GO:0044283
name: small molecule biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw]
comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides.
synonym: "small molecule biosynthesis" EXACT []
is_a: GO:0044281 ! small molecule metabolic process
is_a: GO:0044711 ! single-organism biosynthetic process
created_by: jane
creation_date: 2010-01-26T12:06:49Z

[Term]
id: GO:0044284
name: mitochondrial crista junction
namespace: cellular_component
def: "A tubular structure of relatively uniform size that connects a mitochondrial crista to the mitochondrial inner boundary membrane." [GOC:mcc, NIF_Subcellular:sao1825845900, PMID:21944719, PMID:21987634, PMID:22009199]
synonym: "crista junction" EXACT []
synonym: "cristae junction" EXACT []
xref: NIF_Subcellular:sao1825845900
is_a: GO:0044455 ! mitochondrial membrane part
relationship: part_of GO:0005743 ! mitochondrial inner membrane
created_by: jane
creation_date: 2010-02-02T10:07:39Z

[Term]
id: GO:0044285
name: bridge contact site
namespace: cellular_component
def: "Site of contact between the inner and outer mitochondrial membrane found in neuronal mitochondria; may play a role in maintaining the structural integrity of the inner and outer boundary membranes." [NIF_Subcellular:sao1858501007]
xref: NIF_Subcellular:sao1858501007
is_a: GO:0044455 ! mitochondrial membrane part
created_by: jane
creation_date: 2010-02-02T10:12:13Z

[Term]
id: GO:0044286
name: peg and socket contact
namespace: cellular_component
def: "A cell-cell contact zone that consists of membrane invaginations extending from either cell, which contain tight-, gap-, and adherens junctions. Peg and socket contacts form between endothelial cells and pericytes, and between lens fiber cells." [GOC:tfm, NIF_Subcellular:sao1943947957, PMID:12883993, PMID:16166562, PMID:17591898]
synonym: "ball and socket contact" EXACT [GOC:tfm, PMID:17591898]
xref: NIF_Subcellular:sao1943947957
is_a: GO:0044291 ! cell-cell contact zone
created_by: jane
creation_date: 2010-02-02T10:15:27Z

[Term]
id: GO:0044288
name: puncta adhaerentia
namespace: cellular_component
def: "A small version of the zonula adherens type junction, characterized by a symmetrical adherent point between two cells." [NIF_Subcellular:sao257629430]
xref: NIF_Subcellular:sao257629430
is_a: GO:0005915 ! zonula adherens
created_by: jane
creation_date: 2010-02-04T02:19:38Z

[Term]
id: GO:0044289
name: contact site
namespace: cellular_component
def: "Sites of close apposition of the inner and outer mitochondrial membrane." [NIF_Subcellular:sao447856407]
xref: NIF_Subcellular:sao447856407
is_a: GO:0044455 ! mitochondrial membrane part
created_by: jane
creation_date: 2010-02-04T02:25:11Z

[Term]
id: GO:0044290
name: mitochondrial intracristal space
namespace: cellular_component
def: "The space bounded by the mitochondrial cristae membranes, continuous with the intermembrane space." [NIF_Subcellular:sao508958414]
xref: NIF_Subcellular:sao508958414
is_a: GO:0044429 ! mitochondrial part
created_by: jane
creation_date: 2010-02-04T02:32:10Z

[Term]
id: GO:0044291
name: cell-cell contact zone
namespace: cellular_component
def: "Extended zone of intimate apposition between two cells containing one or more types of intercellular junctions, e.g., the intercalated disk of muscle." [NIF_Subcellular:sao1299635018]
synonym: "cell cell contact zone" EXACT []
xref: NIF_Subcellular:sao1299635018
is_a: GO:0005911 ! cell-cell junction
created_by: jane
creation_date: 2010-02-04T02:42:54Z

[Term]
id: GO:0044292
name: dendrite terminus
namespace: cellular_component
def: "A structure at the distal end of a dendrite adapted to carry out a specific function, e.g. dendriole." [GOC:jl, NIF_Subcellular:sao28175134]
synonym: "dendrite terminal" EXACT []
synonym: "dendrite terminal specialization" RELATED []
synonym: "terminal specialization" RELATED [NIF_Subcellular:sao28175134]
synonym: "terminal specialization of a dendrite" EXACT []
xref: NIF_Subcellular:sao28175134
is_a: GO:0044463 ! cell projection part
is_a: GO:0097458 ! neuron part
relationship: part_of GO:0030425 ! dendrite
created_by: jane
creation_date: 2010-02-04T03:14:37Z

[Term]
id: GO:0044293
name: dendriole
namespace: cellular_component
def: "Small dendrites that makes up a brush structure found as the terminal specialization of a dendrite of a unipolar brush cell (UBC)." [GOC:jl, NIF_Subcellular:sao28175134, NIF_Subcellular:sao295057932, PMID:8300904]
xref: NIF_Subcellular:sao28175134
xref: NIF_Subcellular:sao295057932
is_a: GO:0044292 ! dendrite terminus
created_by: jane
creation_date: 2010-02-04T03:32:02Z

[Term]
id: GO:0044294
name: dendritic growth cone
namespace: cellular_component
def: "The migrating motile tip of a growing nerve cell dendrite." [GOC:jl]
synonym: "dendrite growth cone" EXACT []
xref: NIF_Subcellular:sao1594955670
is_a: GO:0030426 ! growth cone
is_a: GO:0044292 ! dendrite terminus
created_by: jane
creation_date: 2010-02-04T03:45:27Z

[Term]
id: GO:0044295
name: axonal growth cone
namespace: cellular_component
def: "The migrating motile tip of a growing nerve cell axon." [GOC:jl, NIF_Subcellular:sao203987954]
synonym: "axon growth cone" EXACT []
xref: NIF_Subcellular:sao1594955670
xref: NIF_Subcellular:sao203987954
is_a: GO:0030426 ! growth cone
is_a: GO:0033267 ! axon part
created_by: jane
creation_date: 2010-02-04T03:57:16Z

[Term]
id: GO:0044296
name: dendritic tuft
namespace: cellular_component
def: "The terminal specialization found in some types of dendrites which consists of numerous small terminal branches, giving the dendrite a tufted appearance." [NIF_Subcellular:sao1340260079]
synonym: "dendrite tuft" EXACT []
xref: NIF_Subcellular:sao1340260079
is_a: GO:0044292 ! dendrite terminus
created_by: jane
creation_date: 2010-02-04T04:03:29Z

[Term]
id: GO:0044297
name: cell body
namespace: cellular_component
def: "The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections." [GOC:go_curators]
comment: Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections.
subset: goslim_pir
synonym: "cell soma" EXACT []
xref: FBbt:00005107
xref: FMA:67301
xref: Wikipedia:Cell_body
is_a: GO:0044464 ! cell part
created_by: jane
creation_date: 2010-02-05T10:37:16Z

[Term]
id: GO:0044298
name: cell body membrane
namespace: cellular_component
def: "The plasma membrane of a cell that bears surface projections such as axons, dendrites, cilia, or flagella, excluding the plasma membrane on cell projections." [GOC:ecd]
synonym: "cell soma membrane" EXACT []
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0044297 ! cell body
created_by: jane
creation_date: 2010-02-05T10:39:23Z

[Term]
id: GO:0044299
name: C-fiber
namespace: cellular_component
def: "The axon of a dorsal root ganglion cell that are responsive to pain and temperature. C-fibers are small in diameter (0.2-1.5 um) and unmyelinated." [NIF_Subcellular:nlx_subcell_20090210]
synonym: "C-fibre" EXACT []
xref: NIF_Subcellular:nlx_subcell_20090210
is_a: GO:0030424 ! axon
created_by: jane
creation_date: 2010-02-05T11:14:51Z

[Term]
id: GO:0044300
name: cerebellar mossy fiber
namespace: cellular_component
def: "An axon arising from cerebellar projecting cells in the cochlea, vestibular nuclei, spinal cord, reticular formation, cerebellar nuclei and basilar pontine nuclei. Mossy fibers enter through all three cerebellar peduncles and send collaterals to the deep cerebellar nuclei, then branch in the white matter and terminate in the granule cell layer. Through this branching, a given mossy fiber can innervate several folia. Mossy fibers synapse on granule cells. The synaptic contacts are made at enlargements along the length of the mossy fiber called mossy fiber rosettes. The enlargements of the rosettes give the axons as \"mossy\" appearance in Golgi stained preparations." [NIF_Subcellular:nlx_subcell_20090209]
synonym: "cerebellar mossy fibre" EXACT []
xref: NIF_Subcellular:nlx_subcell_20090209
is_a: GO:0030424 ! axon
created_by: jane
creation_date: 2010-02-05T11:16:40Z

[Term]
id: GO:0044301
name: climbing fiber
namespace: cellular_component
def: "The axon of inferior olive neuron that projects to the cerebellar cortex, largely via the inferior cerebellar peduncle. They range in diameter from 1-3 um and are myelinated until they enter the granule cell layer. They give off collaterals to the deep cerebellar nuclei. They synapse extensively with the dendrites of Purkinje cells in the molecular layer, where each fiber branches repeatedly to \"climb\" along the Purkinje cell dendritic tree. Each Purkinje cell is innervated by only a single climbing fiber." [NIF_Subcellular:nlx_subcell_20090203]
synonym: "climbing fibre" EXACT []
xref: NIF_Subcellular:nlx_subcell_20090203
is_a: GO:0030424 ! axon
created_by: jane
creation_date: 2010-02-05T11:20:56Z

[Term]
id: GO:0044302
name: dentate gyrus mossy fiber
namespace: cellular_component
def: "Distinctive, unmyelinated axons produced by granule cells." [NIF_Subcellular:nlx_subcell_20090601, PMID:17765709]
synonym: "dentate gyrus mossy fibre" EXACT []
synonym: "granule cell axon" EXACT []
xref: NIF_Subcellular:nlx_subcell_20090601
is_a: GO:0030424 ! axon
created_by: jane
creation_date: 2010-02-05T11:23:55Z

[Term]
id: GO:0044303
name: axon collateral
namespace: cellular_component
def: "Any of the smaller branches of an axon that emanate from the main axon cylinder." [NIF_Subcellular:sao1470140754]
xref: NIF_Subcellular:sao1470140754
is_a: GO:0033267 ! axon part
created_by: jane
creation_date: 2010-02-05T11:29:04Z

[Term]
id: GO:0044304
name: main axon
namespace: cellular_component
def: "The main axonal trunk, as opposed to the collaterals; i.e., excluding collaterals, terminal, spines, or dendrites." [NIF_Subcellular:sao1596975044]
synonym: "axon shaft" RELATED [PMID:11264310, PMID:24312009]
synonym: "axon trunk" EXACT []
synonym: "axonal shaft" RELATED [PMID:11264310, PMID:24312009]
xref: NIF_Subcellular:sao1596975044
is_a: GO:0033267 ! axon part
created_by: jane
creation_date: 2010-02-05T03:48:17Z

[Term]
id: GO:0044305
name: calyx of Held
namespace: cellular_component
def: "The terminal specialization of a calyciferous axon which forms large synapses in the mammalian auditory central nervous system." [NIF_Subcellular:sao1684283879, PMID:11823805]
xref: NIF_Subcellular:sao1684283879
is_a: GO:0043679 ! axon terminus
created_by: jane
creation_date: 2010-02-05T02:33:20Z

[Term]
id: GO:0044306
name: neuron projection terminus
namespace: cellular_component
def: "The specialized, terminal region of a neuron projection such as an axon or a dendrite." [GOC:jl]
synonym: "nerve terminal" RELATED [PMID:25972809, PMID:9650842]
synonym: "neuron projection terminal" EXACT []
synonym: "neuron terminal specialization" EXACT []
is_a: GO:0044463 ! cell projection part
is_a: GO:0097458 ! neuron part
relationship: part_of GO:0043005 ! neuron projection
created_by: jane
creation_date: 2010-02-05T02:44:04Z

[Term]
id: GO:0044307
name: dendritic branch
namespace: cellular_component
def: "A dendrite arising from another dendrite." [NIF_Subcellular:sao884265541]
synonym: "dendrite branch" EXACT []
xref: NIF_Subcellular:sao884265541
is_a: GO:0044463 ! cell projection part
is_a: GO:0097458 ! neuron part
relationship: part_of GO:0030425 ! dendrite
created_by: jane
creation_date: 2010-02-05T04:18:53Z

[Term]
id: GO:0044308
name: axonal spine
namespace: cellular_component
def: "A spine that originates from the axon, usually from the initial segment." [NIF_Subcellular:sao18239917]
synonym: "axon spine" EXACT []
xref: NIF_Subcellular:sao18239917
is_a: GO:0033267 ! axon part
is_a: GO:0044309 ! neuron spine
created_by: jane
creation_date: 2010-02-05T04:22:13Z

[Term]
id: GO:0044309
name: neuron spine
namespace: cellular_component
def: "A small membranous protrusion, often ending in a bulbous head and attached to the neuron by a narrow stalk or neck." [ISBN:0198504888, NIF_Subcellular:sao1145756102]
synonym: "spine" BROAD []
xref: NIF_Subcellular:sao1145756102
is_a: GO:0043005 ! neuron projection
created_by: jane
creation_date: 2010-02-05T04:25:10Z

[Term]
id: GO:0044310
name: osmiophilic body
namespace: cellular_component
def: "A membrane-bounded vesicle found predominantly in Plasmodium female gametocytes, that becomes progressively more abundant as the gametocyte reaches full maturity. These vesicles lie beneath the subpellicular membrane of the gametocyte, and the release of their contents into the parasitophorous vacuole has been postulated to aid in the escape of gametocytes from the erythrocyte after ingestion by the mosquito." [GOC:jl, PMID:18086189]
is_a: GO:0016023 ! cytoplasmic, membrane-bounded vesicle
created_by: jane
creation_date: 2010-02-18T03:18:32Z

[Term]
id: GO:0044311
name: exoneme
namespace: cellular_component
def: "A dense granule-like organelle of the apical complex of merozoites, released into the parasitophorous vacuole, mediating protease-dependent rupture and parasite exit from the infected erythrocyte." [GOC:jl, PMID:18083092, PMID:18083098]
is_a: GO:0043231 ! intracellular membrane-bounded organelle
relationship: part_of GO:0020007 ! apical complex
created_by: jane
creation_date: 2010-02-18T03:29:56Z

[Term]
id: GO:0044312
name: crystalloid
namespace: cellular_component
def: "A transient, cytoplasmic organelle found in Plasmodium species that resembles a cytoplasmic inclusion body and whose function is poorly understood. Crystalloids form in ookinetes and disappear after ookinete-to-oocyst transformation." [GOC:jl, PMID:19932717]
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle
is_a: GO:0044444 ! cytoplasmic part
created_by: jane
creation_date: 2010-02-18T03:58:55Z

[Term]
id: GO:0044313
name: protein K6-linked deubiquitination
namespace: biological_process
def: "A protein deubiquitination process in which a K6-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 6 of the ubiquitin monomers, is removed from a protein." [GOC:sp]
is_a: GO:0016579 ! protein deubiquitination
created_by: jane
creation_date: 2010-06-01T03:10:11Z

[Term]
id: GO:0044314
name: protein K27-linked ubiquitination
namespace: biological_process
def: "A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 27 of the ubiquitin monomers, is added to a protein." [PMID:19345326]
synonym: "protein K27-linked polyubiquitination" EXACT [GOC:mah]
is_a: GO:0000209 ! protein polyubiquitination
created_by: jane
creation_date: 2010-06-02T11:48:08Z

[Term]
id: GO:0044315
name: protein secretion by the type VII secretion system
namespace: biological_process
def: "The process in which proteins are transferred into the extracellular milieu or directly into host cells, via the type VII protein secretion system." [PMID:17922044, PMID:19876390]
is_a: GO:0009306 ! protein secretion
is_a: GO:0071806 ! protein transmembrane transport
created_by: jane
creation_date: 2010-06-02T11:57:05Z

[Term]
id: GO:0044316
name: cone cell pedicle
namespace: cellular_component
def: "A specialized axon terminus which is produced by retinal cone cells. Pedicles are large, conical, flat end-feet (8-10 micrometers diameter) of the retinal cone axon that lie more or less side by side on the same plane at the outer edge of the outer plexiform layer (OPL)." [http://webvision.med.utah.edu/photo2.html, PMID:10939333]
synonym: "cone pedicle" EXACT []
is_a: GO:0043679 ! axon terminus
created_by: jane
creation_date: 2010-07-14T01:30:02Z

[Term]
id: GO:0044317
name: rod spherule
namespace: cellular_component
def: "A specialized neuron projection which is the site of synaptic transmission produced by retinal rod cells. Rod spherules are small round enlargements of the axon (3-5 micrometers diameter) or even extensions of the cell body." [http://webvision.med.utah.edu/photo2.html]
synonym: "rod cell spherule" EXACT []
synonym: "rod photoreceptor spherule" EXACT []
is_a: GO:0043005 ! neuron projection
created_by: jane
creation_date: 2010-07-14T01:38:07Z

[Term]
id: GO:0044318
name: L-aspartate:fumarate oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-aspartate + fumarate = alpha-iminosuccinate + succinate." [PMID:20149100]
comment: This is based on the finding that L-aspartate oxidase (NadB) of E. coli preferentially uses fumarate as the electron acceptor and does so under anaerobic conditions. The same enzyme uses oxygen as the electron acceptor under aerobic conditions. The EC conflates the two reactions in EC 1.4.3.16 (as they are catalyzed by the same enzyme).
xref: EC:1.4.3.16
is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors
created_by: jane
creation_date: 2010-07-14T01:50:01Z

[Term]
id: GO:0044319
name: wound healing, spreading of cells
namespace: biological_process
def: "The migration of a cell along or through a wound gap that contributes to the reestablishment of a continuous surface." [GOC:jl]
synonym: "cell migration involved in wound healing epiboly" EXACT []
is_a: GO:0016477 ! cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: part_of GO:0090505 ! epiboly involved in wound healing
relationship: part_of GO:0090505 ! epiboly involved in wound healing
created_by: jane
creation_date: 2010-07-14T02:10:01Z

[Term]
id: GO:0044320
name: cellular response to leptin stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism." [GOC:yaf]
is_a: GO:0032870 ! cellular response to hormone stimulus
is_a: GO:0044321 ! response to leptin
created_by: jane
creation_date: 2010-07-14T02:21:32Z

[Term]
id: GO:0044321
name: response to leptin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism]." [GOC:yaf]
synonym: "response to leptin stimulus" EXACT [GOC:dos]
is_a: GO:0009725 ! response to hormone
created_by: jane
creation_date: 2010-07-14T02:31:20Z

[Term]
id: GO:0044322
name: endoplasmic reticulum quality control compartment
namespace: cellular_component
def: "A subcompartment of the endoplasmic reticulum in which proteins with improper or incorrect folding accumulate. Enzymes in this compartment direct proteins with major folding problems to translocation to the cytosol and degradation, and proteins with minor folding problems to the ER, to interact with chaperon proteins." [PMID:11408579]
synonym: "ER quality control compartment" EXACT []
synonym: "ER-derived quality control compartment" RELATED []
synonym: "ERQC" EXACT []
is_a: GO:0044432 ! endoplasmic reticulum part
created_by: janelomax
creation_date: 2010-08-03T01:12:59Z

[Term]
id: GO:0044323
name: retinoic acid-responsive element binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a retinoic acid-responsive element, a variable direct repeat of the sequence PuGGTCA spaced by five nucleotides (DR5) found in the promoters of retinoic acid-responsive genes, to which retinoic acid receptors bind." [GOC:jl, GOC:vw, GOC:yaf, PMID:11327309, PMID:19917671]
comment: Note that as agreed during the transcription overhaul, terms specifying binding to specific transcription regulatory motifs are no longer being created. The level of specificity GO has decided to go to is the "core promoter", "core promoter proximal region" and "enhancer". To capture more detail, please consider using column 16.
synonym: "RARE binding" EXACT []
is_a: GO:0044212 ! transcription regulatory region DNA binding
created_by: janelomax
creation_date: 2010-08-03T03:19:05Z

[Term]
id: GO:0044324
name: regulation of transcription involved in anterior/posterior axis specification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription that contributes to the specification of the anterior/posterior axis." [GOC:jl]
is_a: GO:0006355 ! regulation of transcription, DNA-templated
intersection_of: GO:0006355 ! regulation of transcription, DNA-templated
intersection_of: part_of GO:0009948 ! anterior/posterior axis specification
relationship: part_of GO:0009948 ! anterior/posterior axis specification
created_by: janelomax
creation_date: 2010-08-04T12:35:41Z

[Term]
id: GO:0044325
name: ion channel binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient." [GOC:BHF, GOC:jl]
subset: goslim_chembl
is_a: GO:0005515 ! protein binding
created_by: janelomax
creation_date: 2010-08-04T12:52:59Z

[Term]
id: GO:0044326
name: dendritic spine neck
namespace: cellular_component
def: "Part of the dendritic spine that connects the dendritic shaft to the head of the dendritic spine." [GOC:nln]
synonym: "neck" BROAD [NIF_Subcellular:sao1642908940]
synonym: "pedicle" RELATED [NIF_Subcellular:sao1642908940]
synonym: "spine neck" BROAD [NIF_Subcellular:sao1642908940]
xref: NIF_Subcellular:sao1642908940
is_a: GO:0044456 ! synapse part
is_a: GO:0044463 ! cell projection part
is_a: GO:0097458 ! neuron part
relationship: part_of GO:0043197 ! dendritic spine
created_by: janelomax
creation_date: 2010-08-18T02:31:15Z

[Term]
id: GO:0044327
name: dendritic spine head
namespace: cellular_component
def: "Distal part of the dendritic spine, that carries the post-synaptic density." [GOC:BHF, GOC:nln, GOC:rl]
synonym: "spine head" BROAD [NIF_Subcellular:sao952643730]
xref: NIF_Subcellular:sao952643730
is_a: GO:0044456 ! synapse part
is_a: GO:0044463 ! cell projection part
is_a: GO:0097458 ! neuron part
relationship: has_part GO:0097481 ! neuronal postsynaptic density
relationship: part_of GO:0043197 ! dendritic spine
created_by: janelomax
creation_date: 2010-08-18T02:33:12Z

[Term]
id: GO:0044328
name: canonical Wnt signaling pathway involved in positive regulation of endothelial cell migration
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the positive regulation of endothelial cell migration." [GOC:BHF, GOC:jl]
synonym: "canonical Wnt receptor signaling pathway involved in positive regulation of endothelial cell migration" EXACT [GOC:signaling]
synonym: "canonical Wnt receptor signalling pathway involved in positive regulation of endothelial cell migration" EXACT [GOC:mah]
is_a: GO:0060070 ! canonical Wnt signaling pathway
intersection_of: GO:0060070 ! canonical Wnt signaling pathway
intersection_of: part_of GO:0010595 ! positive regulation of endothelial cell migration
relationship: part_of GO:0010595 ! positive regulation of endothelial cell migration
created_by: janelomax
creation_date: 2010-08-18T04:01:05Z

[Term]
id: GO:0044329
name: canonical Wnt signaling pathway involved in positive regulation of cell-cell adhesion
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the positive regulation of cell to cell adhesion." [GOC:BHF, GOC:jl]
synonym: "canonical Wnt receptor signaling pathway involved in positive regulation of cell-cell adhesion" EXACT []
synonym: "canonical Wnt receptor signalling pathway involved in positive regulation of cell-cell adhesion" EXACT [GOC:mah]
synonym: "canonical Wnt-activated signaling pathway involved in positive regulation of cell-cell adhesion" EXACT [GOC:signaling]
is_a: GO:0060070 ! canonical Wnt signaling pathway
intersection_of: GO:0060070 ! canonical Wnt signaling pathway
intersection_of: part_of GO:0022409 ! positive regulation of cell-cell adhesion
relationship: part_of GO:0022409 ! positive regulation of cell-cell adhesion
created_by: janelomax
creation_date: 2010-08-18T04:16:50Z

[Term]
id: GO:0044330
name: canonical Wnt signaling pathway involved in positive regulation of wound healing
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in positive regulation of wound healing." [GOC:BHF, GOC:jl]
synonym: "canonical Wnt receptor signaling pathway involved in positive regulation of wound healing" EXACT []
synonym: "canonical Wnt receptor signalling pathway involved in positive regulation of wound healing" EXACT [GOC:mah]
synonym: "canonical Wnt-activated signaling pathway involved in positive regulation of wound healing" EXACT [GOC:signaling]
is_a: GO:0060070 ! canonical Wnt signaling pathway
intersection_of: GO:0060070 ! canonical Wnt signaling pathway
intersection_of: part_of GO:0090303 ! positive regulation of wound healing
relationship: part_of GO:0090303 ! positive regulation of wound healing
created_by: janelomax
creation_date: 2010-08-18T04:21:21Z

[Term]
id: GO:0044331
name: cell-cell adhesion mediated by cadherin
namespace: biological_process
def: "The attachment of one cell to another cell via a cadherin, transmembrane proteins having repeating extracellular calcium ion binding domains." [GOC:ha, GOC:hjd, GOC:jl, PMID:10923970]
is_a: GO:0016337 ! single organismal cell-cell adhesion
created_by: janelomax
creation_date: 2010-08-20T10:24:54Z

[Term]
id: GO:0044332
name: Wnt signaling pathway involved in dorsal/ventral axis specification
namespace: biological_process
def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell contributing to the establishment, maintenance and elaboration of the dorsal/ventral axis." [GOC:jl, GOC:yaf]
synonym: "Wnt receptor signaling pathway involved in dorsal/ventral axis specification" EXACT []
synonym: "Wnt receptor signalling pathway involved in dorsal/ventral axis specification" EXACT [GOC:mah]
synonym: "Wnt-activated signaling pathway involved in dorsal/ventral axis specification" EXACT [GOC:signaling]
is_a: GO:0016055 ! Wnt signaling pathway
intersection_of: GO:0016055 ! Wnt signaling pathway
intersection_of: part_of GO:0009950 ! dorsal/ventral axis specification
relationship: part_of GO:0009950 ! dorsal/ventral axis specification
created_by: janelomax
creation_date: 2010-08-20T11:30:30Z

[Term]
id: GO:0044333
name: Wnt signaling pathway involved in digestive tract morphogenesis
namespace: biological_process
def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell contributing to the generation and the organization of the digestive tract." [GOC:BHF, GOC:jl]
synonym: "Wnt receptor signaling pathway involved in digestive tract morphogenesis" EXACT []
synonym: "Wnt receptor signalling pathway involved in digestive tract morphogenesis" EXACT [GOC:mah]
synonym: "Wnt-activated signaling pathway involved in digestive tract morphogenesis" RELATED [GOC:signaling]
is_a: GO:0016055 ! Wnt signaling pathway
intersection_of: GO:0016055 ! Wnt signaling pathway
intersection_of: part_of GO:0048546 ! digestive tract morphogenesis
relationship: part_of GO:0048546 ! digestive tract morphogenesis
created_by: janelomax
creation_date: 2010-08-20T11:36:23Z

[Term]
id: GO:0044334
name: canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the positive regulation of epithelial cell to mesenchymal cell transition." [GOC:BHF, GOC:jl]
synonym: "canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition" EXACT []
synonym: "canonical Wnt receptor signalling pathway involved in positive regulation of epithelial to mesenchymal transition" EXACT [GOC:mah]
synonym: "canonical Wnt-activated signaling pathway involved in positive regulation of epithelial to mesenchymal transition" EXACT [GOC:signaling]
is_a: GO:0060070 ! canonical Wnt signaling pathway
intersection_of: GO:0060070 ! canonical Wnt signaling pathway
intersection_of: part_of GO:0010718 ! positive regulation of epithelial to mesenchymal transition
relationship: part_of GO:0010718 ! positive regulation of epithelial to mesenchymal transition
created_by: janelomax
creation_date: 2010-08-20T02:35:17Z

[Term]
id: GO:0044335
name: canonical Wnt signaling pathway involved in neural crest cell differentiation
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in neural crest cell differentiation." [GOC:BHF, GOC:jl]
synonym: "canonical Wnt receptor signaling pathway involved in neural crest cell differentiation" EXACT []
synonym: "canonical Wnt receptor signalling pathway involved in neural crest cell differentiation" EXACT [GOC:mah]
synonym: "canonical Wnt-activated signaling pathway involved in neural crest cell differentiation" EXACT [GOC:signaling]
is_a: GO:0060070 ! canonical Wnt signaling pathway
intersection_of: GO:0060070 ! canonical Wnt signaling pathway
intersection_of: part_of GO:0014033 ! neural crest cell differentiation
relationship: part_of GO:0014033 ! neural crest cell differentiation
created_by: janelomax
creation_date: 2010-08-20T03:02:34Z

[Term]
id: GO:0044336
name: canonical Wnt signaling pathway involved in negative regulation of apoptotic process
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the negative regulation of apoptotic process." [GOC:BHF, GOC:jl, GOC:mtg_apoptosis]
synonym: "canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis" NARROW []
synonym: "canonical Wnt receptor signaling pathway involved in negative regulation of apoptotic process" EXACT [GOC:signaling]
synonym: "canonical Wnt receptor signalling pathway involved in negative regulation of apoptosis" EXACT [GOC:mah]
is_a: GO:0060070 ! canonical Wnt signaling pathway
intersection_of: GO:0060070 ! canonical Wnt signaling pathway
intersection_of: part_of GO:0043066 ! negative regulation of apoptotic process
relationship: part_of GO:0043066 ! negative regulation of apoptotic process
created_by: janelomax
creation_date: 2010-08-20T03:07:53Z

[Term]
id: GO:0044337
name: canonical Wnt signaling pathway involved in positive regulation of apoptotic process
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the positive regulation of apoptotic process." [GOC:BHF, GOC:jl, GOC:mtg_apoptosis]
synonym: "canonical Wnt receptor signaling pathway involved in positive regulation of apoptosis" NARROW []
synonym: "canonical Wnt receptor signaling pathway involved in positive regulation of apoptotic process" EXACT []
synonym: "canonical Wnt receptor signalling pathway involved in positive regulation of apoptosis" EXACT [GOC:mah]
synonym: "canonical Wnt-activated signaling pathway involved in positive regulation of apoptotic process" EXACT [GOC:signaling]
is_a: GO:0060070 ! canonical Wnt signaling pathway
intersection_of: GO:0060070 ! canonical Wnt signaling pathway
intersection_of: part_of GO:0043065 ! positive regulation of apoptotic process
relationship: part_of GO:0043065 ! positive regulation of apoptotic process
created_by: janelomax
creation_date: 2010-08-20T03:08:24Z

[Term]
id: GO:0044338
name: canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in mesenchymal stem cell differentiation." [GOC:BHF, GOC:jl]
synonym: "canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation" EXACT []
synonym: "canonical Wnt receptor signalling pathway involved in mesenchymal stem cell differentiation" EXACT [GOC:mah]
synonym: "canonical Wnt-activated signaling pathway involved in mesenchymal stem cell differentiation" EXACT [GOC:signaling]
is_a: GO:0060070 ! canonical Wnt signaling pathway
intersection_of: GO:0060070 ! canonical Wnt signaling pathway
intersection_of: part_of GO:0072497 ! mesenchymal stem cell differentiation
relationship: part_of GO:0072497 ! mesenchymal stem cell differentiation
created_by: janelomax
creation_date: 2010-08-20T03:43:36Z

[Term]
id: GO:0044339
name: canonical Wnt signaling pathway involved in osteoblast differentiation
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in osteoblast differentiation." [GOC:BHF, GOC:jl]
synonym: "canonical Wnt receptor signaling pathway involved in osteoblast differentiation" EXACT []
synonym: "canonical Wnt receptor signalling pathway involved in osteoblast differentiation" EXACT [GOC:mah]
synonym: "canonical Wnt-activated signaling pathway involved in osteoblast differentiation" EXACT [GOC:signaling]
is_a: GO:0060070 ! canonical Wnt signaling pathway
intersection_of: GO:0060070 ! canonical Wnt signaling pathway
intersection_of: part_of GO:0001649 ! osteoblast differentiation
relationship: part_of GO:0001649 ! osteoblast differentiation
created_by: janelomax
creation_date: 2010-08-20T03:52:11Z

[Term]
id: GO:0044340
name: canonical Wnt signaling pathway involved in regulation of cell proliferation
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to modulating the rate or frequency of cell proliferation." [GOC:BHF, GOC:jl]
synonym: "canonical Wnt receptor signaling pathway involved in regulation of cell proliferation" EXACT []
synonym: "canonical Wnt receptor signalling pathway involved in regulation of cell proliferation" EXACT [GOC:mah]
synonym: "canonical Wnt-activated signaling pathway involved in regulation of cell proliferation" EXACT [GOC:signaling]
is_a: GO:0060070 ! canonical Wnt signaling pathway
intersection_of: GO:0060070 ! canonical Wnt signaling pathway
intersection_of: part_of GO:0008283 ! cell proliferation
relationship: part_of GO:0008283 ! cell proliferation
relationship: part_of GO:0042127 ! regulation of cell proliferation
created_by: janelomax
creation_date: 2010-08-20T03:57:25Z

[Term]
id: GO:0044341
name: sodium-dependent phosphate transport
namespace: biological_process
def: "The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, by a mechanism dependent upon sodium ions." [GOC:BHF, GOC:jl]
is_a: GO:0006817 ! phosphate ion transport
created_by: janelomax
creation_date: 2010-08-20T04:16:15Z

[Term]
id: GO:0044342
name: type B pancreatic cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of pancreatic B cells, resulting in the expansion of an pancreatic B cell population. Pancreatic B cell are cells of the pancreas that secrete insulin." [GOC:jl, GOC:yaf]
synonym: "pancreatic B cell proliferation" EXACT [GOC:mah]
synonym: "pancreatic beta cell proliferation" EXACT []
is_a: GO:0050673 ! epithelial cell proliferation
created_by: janelomax
creation_date: 2010-08-25T01:44:51Z

[Term]
id: GO:0044343
name: canonical Wnt signaling pathway involved in regulation of type B pancreatic cell proliferation
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that modulates the rate or frequency of pancreatic B cell proliferation. Pancreatic B cell are cells of the pancreas that secrete insulin." [GOC:jl, GOC:yaf]
synonym: "canonical Wnt receptor signaling pathway involved in pancreatic beta cell proliferation" RELATED []
synonym: "canonical Wnt receptor signaling pathway involved in regulation of pancreatic B cell proliferation" EXACT [GOC:mah]
synonym: "canonical Wnt receptor signaling pathway involved in regulation of type B pancreatic cell proliferation" EXACT []
synonym: "canonical Wnt receptor signalling pathway involved in regulation of pancreatic B cell proliferation" EXACT [GOC:mah]
synonym: "canonical Wnt receptor signalling pathway involved in regulation of type B pancreatic cell proliferation" EXACT [GOC:mah]
synonym: "canonical Wnt-activated signaling pathway involved in regulation of type B pancreatic cell proliferation" EXACT [GOC:signaling]
is_a: GO:0044340 ! canonical Wnt signaling pathway involved in regulation of cell proliferation
intersection_of: GO:0060070 ! canonical Wnt signaling pathway
intersection_of: part_of GO:0061469 ! regulation of type B pancreatic cell proliferation
relationship: part_of GO:0061469 ! regulation of type B pancreatic cell proliferation
created_by: janelomax
creation_date: 2010-08-25T01:53:22Z

[Term]
id: GO:0044344
name: cellular response to fibroblast growth factor stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an fibroblast growth factor stimulus." [GOC:jl, GOC:yaf]
synonym: "cellular response to FGF stimulus" EXACT []
is_a: GO:0071363 ! cellular response to growth factor stimulus
is_a: GO:0071495 ! cellular response to endogenous stimulus
is_a: GO:0071774 ! response to fibroblast growth factor
created_by: janelomax
creation_date: 2010-08-25T02:00:51Z

[Term]
id: GO:0044345
name: stromal-epithelial cell signaling involved in prostate gland development
namespace: biological_process
def: "The process of transferring information from a stromal cell to an epithelial cell where it is received and interpreted, as part of prostate gland development." [GOC:jl, GOC:yaf]
synonym: "stromal-epithelial cell signalling involved in prostate gland development" EXACT [GOC:mah]
is_a: GO:0007267 ! cell-cell signaling
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
relationship: part_of GO:0030850 ! prostate gland development
created_by: janelomax
creation_date: 2010-08-25T02:06:34Z

[Term]
id: GO:0044346
name: fibroblast apoptotic process
namespace: biological_process
def: "Any apoptotic process in a fibroblast, a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules." [CL:0000057, GOC:jl, GOC:mtg_apoptosis, GOC:yaf]
synonym: "fibroblast apoptosis" NARROW []
is_a: GO:0006915 ! apoptotic process
created_by: janelomax
creation_date: 2010-09-23T11:33:38Z

[Term]
id: GO:0044347
name: cell wall polysaccharide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cell wall polysaccharides." [GOC:mengo_curators]
subset: gosubset_prok
synonym: "cell wall polysaccharide breakdown" EXACT [GOC:mah]
is_a: GO:0010383 ! cell wall polysaccharide metabolic process
is_a: GO:0016998 ! cell wall macromolecule catabolic process
created_by: janelomax
creation_date: 2011-07-28T01:24:57Z

[Term]
id: GO:0044348
name: plant-type cell wall cellulose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, which forms part of the cell wall." [GOC:mengo_curators]
subset: gosubset_prok
synonym: "plant-type cell wall polysaccharide breakdown" EXACT [GOC:mah]
is_a: GO:0044347 ! cell wall polysaccharide catabolic process
is_a: GO:0052541 ! plant-type cell wall cellulose metabolic process
created_by: janelomax
creation_date: 2011-07-28T01:48:23Z

[Term]
id: GO:0044349
name: DNA excision
namespace: biological_process
def: "The removal of a section of DNA from a larger DNA molecule by the making of dual incisions that flank the section to be excised." [GOC:jl]
is_a: GO:0006259 ! DNA metabolic process
created_by: janelomax
creation_date: 2011-08-03T10:56:37Z

[Term]
id: GO:0044350
name: micropinocytosis
namespace: biological_process
def: "An endocytosis process that results in the uptake of liquid material by cells from their external environment by invagination of the plasma membrane to form uncoated micropinosomes, differentiated from macropinosomes by their smaller size, on average 95 nm." [PMID:14731589, PMID:14732047]
synonym: "clathrin-independent pinocytosis" BROAD []
is_a: GO:0006907 ! pinocytosis
created_by: janelomax
creation_date: 2011-08-11T10:26:26Z

[Term]
id: GO:0044351
name: macropinocytosis
namespace: biological_process
def: "An endocytosis process that results in the uptake of liquid material by cells from their external environment by the 'ruffling' of the cell membrane to form heterogeneously sized intracellular vesicles called macropinosomes, which can be up to 5 micrometers in size." [PMID:14732047]
synonym: "clathrin-independent pinocytosis" BROAD []
is_a: GO:0006907 ! pinocytosis
created_by: janelomax
creation_date: 2011-08-11T10:26:42Z

[Term]
id: GO:0044352
name: pinosome
namespace: cellular_component
def: "A membrane-bounded, uncoated intracellular vesicle formed by the process of pinocytosis." [PMID:14731589, PMID:14732047]
synonym: "pinocytic vesicle" EXACT [NIF_Subcellular:sao1925368674]
xref: NIF_Subcellular:sao1925368674
is_a: GO:0005768 ! endosome
created_by: janelomax
creation_date: 2011-08-11T10:51:13Z

[Term]
id: GO:0044353
name: micropinosome
namespace: cellular_component
def: "A membrane-bounded, uncoated intracellular vesicle formed by the process of micropinocytosis." [PMID:14731589, PMID:14732047]
is_a: GO:0044352 ! pinosome
created_by: janelomax
creation_date: 2011-08-11T10:51:27Z

[Term]
id: GO:0044354
name: macropinosome
namespace: cellular_component
def: "A membrane-bounded, uncoated intracellular vesicle formed by the process of macropinocytosis." [PMID:14732047]
is_a: GO:0044352 ! pinosome
created_by: janelomax
creation_date: 2011-08-11T10:51:42Z

[Term]
id: GO:0044355
name: clearance of foreign intracellular DNA
namespace: biological_process
def: "A defense process that protects an organism from invading foreign DNA." [GO:jl]
is_a: GO:0006952 ! defense response
created_by: janelomax
creation_date: 2011-08-11T11:25:43Z

[Term]
id: GO:0044356
name: clearance of foreign intracellular DNA by conversion of DNA cytidine to uridine
namespace: biological_process
def: "A defense process that protects an organism from invading foreign DNA. The process begins by the deamination of foreign double-stranded DNA cytidines to uridines. These atypical DNA nucleosides are then converted by a uracil DNA glycosylase to abasic lesions, and the process ends with the degradation of the foreign DNA." [GO:jl, PMID:20062055]
is_a: GO:0044355 ! clearance of foreign intracellular DNA
created_by: janelomax
creation_date: 2011-08-11T11:27:07Z

[Term]
id: GO:0044357
name: regulation of rRNA stability
namespace: biological_process
def: "Any process that modulates the propensity of rRNA molecules to degradation. Includes processes that both stabilize and destabilize rRNAs." [GOC:jl]
synonym: "regulation of ribosomal RNA stability" EXACT []
is_a: GO:0043487 ! regulation of RNA stability
created_by: janelomax
creation_date: 2011-08-31T09:57:54Z

[Term]
id: GO:0044358
name: envenomation resulting in hemorrhagic damage to other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with vascular damage and hemorrhage in the bitten organism." [PMID:10441379, PMID:20614020]
is_a: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism
created_by: janelomax
creation_date: 2011-10-26T04:24:59Z

[Term]
id: GO:0044359
name: modulation of molecular function in other organism
namespace: biological_process
def: "The process in which an organism effects a change in the function of proteins in a second organism." [GOC:jl]
is_a: GO:0035821 ! modification of morphology or physiology of other organism
is_a: GO:0065009 ! regulation of molecular function
created_by: janelomax
creation_date: 2011-10-27T01:28:16Z

[Term]
id: GO:0044360
name: modulation of voltage-gated potassium channel activity in other organism
namespace: biological_process
def: "Any process in which an organism effects a change in the frequency, rate or extent of the activity of a voltage-gated potassium channel in another organism." [GOC:jl]
is_a: GO:0044363 ! modulation of potassium channel activity in other organism
created_by: janelomax
creation_date: 2011-10-27T02:09:28Z

[Term]
id: GO:0044361
name: negative regulation of voltage-gated potassium channel activity in other organism
namespace: biological_process
def: "Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a voltage-gated potassium channel in another organism." [GOC:jl]
is_a: GO:0044360 ! modulation of voltage-gated potassium channel activity in other organism
is_a: GO:0044362 ! negative regulation of molecular function in other organism
created_by: janelomax
creation_date: 2011-10-27T02:11:52Z

[Term]
id: GO:0044362
name: negative regulation of molecular function in other organism
namespace: biological_process
def: "Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the function of proteins in a second organism." [GOC:jl]
is_a: GO:0044092 ! negative regulation of molecular function
is_a: GO:0044359 ! modulation of molecular function in other organism
created_by: janelomax
creation_date: 2011-10-27T02:12:49Z

[Term]
id: GO:0044363
name: modulation of potassium channel activity in other organism
namespace: biological_process
def: "Any process in which an organism effects a change in the frequency, rate or extent of the activity of a potassium channel in another organism." [GOC:jl]
is_a: GO:0044561 ! modulation of ion channel activity in other organism
created_by: janelomax
creation_date: 2011-10-27T02:19:32Z

[Term]
id: GO:0044364
name: disruption of cells of other organism
namespace: biological_process
def: "A process in which an organism has a negative effect on the functioning of the second organism's cells." [GOC:jl]
is_a: GO:0035821 ! modification of morphology or physiology of other organism
created_by: janelomax
creation_date: 2011-10-27T02:27:48Z

[Term]
id: GO:0044365
name: envenomation resulting in modulation of platelet aggregation in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change to the frequency, rate or extent of platelet aggregation in the bitten organism." [GOC:fj, GOC:jl]
synonym: "envenomation resulting in regulation of platelet aggregation in other organism" EXACT []
is_a: GO:0044468 ! envenomation resulting in modulation of blood coagulation in other organism
intersection_of: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism
intersection_of: has_part GO:0035892 ! modulation of platelet aggregation in other organism
relationship: has_part GO:0035892 ! modulation of platelet aggregation in other organism
created_by: janelomax
creation_date: 2011-10-27T02:36:43Z

[Term]
id: GO:0044366
name: feeding on or from other organism
namespace: biological_process
def: "The process of consuming the whole or part of another organism for the purposes of nutrition." [GOC:jl]
comment: This term covers more than feeding behavior, including, for example,  the processes of feeding by plants and fungi.
is_a: GO:0051704 ! multi-organism process
created_by: janelomax
creation_date: 2011-10-27T03:30:30Z

[Term]
id: GO:0044367
name: feeding from tissue of other organism
namespace: biological_process
def: "The behaviour of consuming part of another organism for the purposes of nutrition via a particular tissue e.g. vascular tissue." [GOC:jl]
is_a: GO:0044366 ! feeding on or from other organism
created_by: janelomax
creation_date: 2011-10-27T03:31:23Z

[Term]
id: GO:0044368
name: feeding from vascular tissue of another organism
namespace: biological_process
def: "The behaviour of consuming part of another organism for the purposes of nutrition via a vascular tissue." [GOC:jl]
is_a: GO:0044367 ! feeding from tissue of other organism
created_by: janelomax
creation_date: 2011-10-27T03:52:32Z

[Term]
id: GO:0044369
name: feeding on blood of other organism
namespace: biological_process
def: "The behaviour of feeding on the blood of another organism via specialized mouth parts and chemical agents used to penetrate vascular structures in the skin of hosts." [GOC:jl]
synonym: "hematophagy" EXACT []
synonym: "phlebotomy" EXACT []
synonym: "taking of blood meal" EXACT []
is_a: GO:0044368 ! feeding from vascular tissue of another organism
created_by: janelomax
creation_date: 2011-10-27T03:53:33Z

[Term]
id: GO:0044370
name: injection of substance into other organism during feeding on blood of other organism
namespace: biological_process
def: "The process of forcing a substance into the bloodstream of another organism, whilst feeding on blood of other organism. The substance may facilitate the feeding process, e.g. by preventing the blood from clotting." [GOC:jl]
is_a: GO:0035737 ! injection of substance in to other organism
relationship: part_of GO:0044369 ! feeding on blood of other organism
created_by: janelomax
creation_date: 2011-10-27T03:57:28Z

[Term]
id: GO:0044371
name: feeding from phloem of other organism
namespace: biological_process
def: "The behaviour of consuming phloem sap, usually by penetration of the phloem wall, for the purposes of nutrition." [GOC:jl]
synonym: "feeding from plant phloem" EXACT []
synonym: "feeding on plant sap" EXACT []
is_a: GO:0044368 ! feeding from vascular tissue of another organism
created_by: janelomax
creation_date: 2011-10-27T04:06:52Z

[Term]
id: GO:0044372
name: feeding from xylem of other organism
namespace: biological_process
def: "The behaviour of consuming xylem exudate from plant xylem tissue for the purposes of nutrition." [GOC:jl]
synonym: "feeding from plant xylem" EXACT []
synonym: "feeding from xylem of plant" EXACT []
synonym: "feeding on xylem exudate" EXACT []
is_a: GO:0044368 ! feeding from vascular tissue of another organism
created_by: janelomax
creation_date: 2011-10-27T04:42:45Z

[Term]
id: GO:0044373
name: cytokinin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a cytokinin, any of a class of adenine-derived compounds that can function in plants as growth regulators." [GOC:jl]
is_a: GO:0042562 ! hormone binding
created_by: janelomax
creation_date: 2011-12-01T03:42:10Z

[Term]
id: GO:0044374
name: sequence-specific DNA binding, bending
namespace: molecular_function
def: "The activity of binding selectively and non-covalently to DNA in a sequence-specific manner and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:jl, GOC:vw]
subset: gosubset_prok
synonym: "DNA bending involving sequence-specific DNA binding" EXACT []
is_a: GO:0008301 ! DNA binding, bending
is_a: GO:1990837 ! sequence-specific double-stranded DNA binding
created_by: janelomax
creation_date: 2011-12-01T04:05:59Z

[Term]
id: GO:0044375
name: regulation of peroxisome size
namespace: biological_process
def: "Any process that modulates the volume of a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:jl]
is_a: GO:0032535 ! regulation of cellular component size
created_by: janelomax
creation_date: 2011-12-01T04:37:59Z

[Term]
id: GO:0044376
name: RNA polymerase II complex import to nucleus
namespace: biological_process
alt_id: GO:0098738
def: "The directed movement of the DNA-directed RNA polymerase II core complex from the cytoplasm into the nucleus." [GOC:dos, GOC:jl]
synonym: "DNA-directed RNA polymerase II core complex import into nucleus" EXACT [GO:0098738]
synonym: "DNA-directed RNA polymerase II core complex localization to nucleus" EXACT []
synonym: "RNA polymerase II complex import into nucleus" EXACT []
synonym: "RNA polymerase II complex localisation to nucleus" EXACT [GOC:mah]
is_a: GO:0006606 ! protein import into nucleus
is_a: GO:0015833 ! peptide transport
is_a: GO:0034629 ! cellular protein complex localization
created_by: janelomax
creation_date: 2011-12-01T04:43:03Z

[Term]
id: GO:0044377
name: RNA polymerase II core promoter proximal region sequence-specific DNA binding, bending
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:jl]
is_a: GO:0000978 ! RNA polymerase II core promoter proximal region sequence-specific DNA binding
is_a: GO:0044374 ! sequence-specific DNA binding, bending
created_by: janelomax
creation_date: 2011-12-08T01:38:21Z

[Term]
id: GO:0044378
name: non-sequence-specific DNA binding, bending
namespace: molecular_function
def: "The activity of binding selectively and non-covalently to DNA in a sequence-independent manner and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:jl, GOC:vw, PMID:20123079]
subset: gosubset_prok
synonym: "DNA bending involving non-sequence-specific DNA binding" EXACT []
is_a: GO:0008301 ! DNA binding, bending
created_by: janelomax
creation_date: 2011-12-08T02:02:13Z

[Term]
id: GO:0044379
name: protein localization to actin cortical patch
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, an actin cortical patch." [GOC:mah, PMID:21620704]
synonym: "protein localisation to actin cortical patch" EXACT [GOC:mah]
is_a: GO:0072697 ! protein localization to cell cortex
is_a: GO:1903119 ! protein localization to actin cytoskeleton
created_by: janelomax
creation_date: 2011-12-08T02:28:42Z

[Term]
id: GO:0044380
name: protein localization to cytoskeleton
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within the cytoskeleton." [GOC:jl]
synonym: "protein localisation to cytoskeleton" EXACT [GOC:mah]
is_a: GO:0033365 ! protein localization to organelle
created_by: janelomax
creation_date: 2011-12-13T11:43:24Z

[Term]
id: GO:0044381
name: glucose import in response to insulin stimulus
namespace: biological_process
def: "The directed movement of the hexose monosaccharide glucose into a cell as a result of an insulin stimulus." [GOC:BHF, PMID:19079291]
synonym: "cellular glucose import in response to insulin stimulus" EXACT []
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0046323 ! glucose import
relationship: part_of GO:0032869 ! cellular response to insulin stimulus
created_by: janelomax
creation_date: 2011-12-08T02:44:01Z

[Term]
id: GO:0044382
name: CLRC ubiquitin ligase complex localization to heterochromatin
namespace: biological_process
def: "The process by which a CLRC ubiquitin ligase complex is transported to, or maintained in, heterochromatin. CLRC ubiquitin ligase complex is an active cullin-dependent E3 ubiquitin ligase complex essential for heterochromatin assembly by RNAi and histone H3K9 methylation." [GOC:jl]
synonym: "CLRC ubiquitin ligase complex localisation to heterochromatin" EXACT [GOC:mah]
is_a: GO:0034629 ! cellular protein complex localization
is_a: GO:0097355 ! protein localization to heterochromatin
created_by: janelomax
creation_date: 2011-12-13T03:37:18Z

[Term]
id: GO:0044383
name: host chromosome
namespace: cellular_component
def: "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information, occurring within a host cell." [GOC:jl]
is_a: GO:0033647 ! host intracellular organelle
created_by: janelomax
creation_date: 2011-12-13T03:58:38Z

[Term]
id: GO:0044384
name: host outer membrane
namespace: cellular_component
def: "The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites, occurring in a host cell." [GOC:jl]
comment: This term covers the outer membrane of the host cell envelope or the outer membrane of a host organelle. For the outer layer of the host cell envelope specifically, see host cell outer membrane ; GO:0039662.
synonym: "host cell outer membrane" RELATED [GOC:bf]
is_a: GO:0033644 ! host cell membrane
created_by: janelomax
creation_date: 2011-12-13T04:02:07Z

[Term]
id: GO:0044385
name: integral to membrane of host cell
namespace: cellular_component
def: "Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. Occurring in a host cell." [GOC:jl]
is_a: GO:0033643 ! host cell part
relationship: part_of GO:0033644 ! host cell membrane
created_by: janelomax
creation_date: 2011-12-13T04:08:03Z

[Term]
id: GO:0044386
name: integral to host endoplasmic reticulum membrane
namespace: cellular_component
def: "Penetrating at least one phospholipid bilayer of an endoplasmic reticulum membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. Occurring in a host cell." [GOC:jl]
is_a: GO:0044385 ! integral to membrane of host cell
relationship: part_of GO:0044167 ! host cell endoplasmic reticulum membrane
created_by: janelomax
creation_date: 2011-12-13T04:11:30Z

[Term]
id: GO:0044387
name: negative regulation of protein kinase activity by regulation of protein phosphorylation
namespace: biological_process
def: "The stopping, prevention, or reduction in frequency, rate or extent of protein kinase activity as a result of regulating the phosphorylation status of that protein kinase." [GOC:jl]
is_a: GO:0006469 ! negative regulation of protein kinase activity
created_by: janelomax
creation_date: 2011-12-13T04:49:36Z

[Term]
id: GO:0044388
name: small protein activating enzyme binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a small protein activating enzyme, such as ubiquitin-activating enzyme." [GOC:jl]
is_a: GO:0019899 ! enzyme binding
created_by: janelomax
creation_date: 2011-12-15T04:28:17Z

[Term]
id: GO:0044389
name: ubiquitin-like protein ligase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a ubiquitin-like protein ligase, such as ubiquitin-ligase." [GOC:jl]
synonym: "E3 protein ligase binding" EXACT []
synonym: "small conjugating protein ligase binding" EXACT [GOC:dph]
is_a: GO:0019899 ! enzyme binding
created_by: janelomax
creation_date: 2011-12-15T04:33:20Z

[Term]
id: GO:0044390
name: ubiquitin-like protein conjugating enzyme binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a ubiquitin-like protein conjugating enzyme such as ubiquitin conjugating enzyme." [GOC:jl]
synonym: "E2 protein ligase binding" EXACT []
synonym: "small protein conjugating enzyme binding" EXACT [GOC:dph]
is_a: GO:0019899 ! enzyme binding
created_by: janelomax
creation_date: 2011-12-15T04:38:44Z

[Term]
id: GO:0044391
name: ribosomal subunit
namespace: cellular_component
def: "Either of the two subunits of a ribosome: the ribosomal large subunit or the ribosomal small subunit." [GOC:jl]
subset: gosubset_prok
is_a: GO:0030529 ! intracellular ribonucleoprotein complex
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0044446 ! intracellular organelle part
relationship: part_of GO:0005840 ! ribosome
created_by: janelomax
creation_date: 2011-12-15T04:47:59Z

[Term]
id: GO:0044392
name: peptidyl-lysine malonylation
namespace: biological_process
def: "The addition of a malonyl group (CO-CH2-CO) to peptidyl-lysine to form N6-malonyl-L-lysine." [GOC:jsg, GOC:sp, PMID:21908771, PMID:22076378, RESID:AA0568]
synonym: "lysine malonylation" EXACT [PMID:21908771]
xref: RESID:AA0568
is_a: GO:0018205 ! peptidyl-lysine modification
is_a: GO:0044394 ! protein malonylation
created_by: rfoulger
creation_date: 2011-12-12T09:31:42Z

[Term]
id: GO:0044393
name: microspike
namespace: cellular_component
def: "A dynamic, actin-rich projection extending from the surface of a migrating animal cell." [PMID:11429692, PMID:12153987, PMID:19095735]
comment: Although in some literature 'microspike' and 'filopodium' are used synonymously, in GO microspike refers to a cell projection that is distinct from a filopodium. See also 'filopodium ; GO:0030175'.
is_a: GO:0042995 ! cell projection
created_by: rfoulger
creation_date: 2011-12-06T01:31:16Z

[Term]
id: GO:0044394
name: protein malonylation
namespace: biological_process
def: "The modification of a protein amino acid by the addition of a malonyl (CO-CH2-CO) group." [CHEBI:25134, GOC:sp]
is_a: GO:0043543 ! protein acylation
created_by: rfoulger
creation_date: 2011-12-12T09:26:37Z

[Term]
id: GO:0044395
name: protein targeting to vacuolar membrane
namespace: biological_process
def: "The process of directing proteins towards the vacuolar membrane; usually uses signals contained within the protein." [GOC:jl]
is_a: GO:0006612 ! protein targeting to membrane
is_a: GO:0006623 ! protein targeting to vacuole
is_a: GO:1903778 ! protein localization to vacuolar membrane
created_by: janelomax
creation_date: 2011-12-21T02:54:44Z

[Term]
id: GO:0044396
name: actin cortical patch organization
namespace: biological_process
def: "A process that is carried out at the cellular level and results in the assembly, arrangement of constituent parts, or disassembly of an actin cortical patch, a discrete actin-containing structure found at the plasma membrane in cells, at sites of endocytosis." [GOC:jl]
synonym: "actin cortical patch organisation" EXACT [GOC:mah]
is_a: GO:0016043 ! cellular component organization
is_a: GO:0044763 ! single-organism cellular process
created_by: janelomax
creation_date: 2011-12-21T03:33:25Z

[Term]
id: GO:0044397
name: actin cortical patch internalization
namespace: biological_process
def: "A process of actin cortical patch localization in which the patch moves from the cell surface to the inside of the cell." [GOC:mah]
is_a: GO:0044396 ! actin cortical patch organization
is_a: GO:0051666 ! actin cortical patch localization
is_a: GO:1902580 ! single-organism cellular localization
relationship: has_part GO:0030041 ! actin filament polymerization
created_by: janelomax
creation_date: 2011-12-21T03:37:11Z

[Term]
id: GO:0044398
name: envenomation resulting in induction of edema in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the swelling of soft tissues of the bitten organism as a result of excess water accumulation." [GOC:jl, PMID:20562011]
synonym: "envenomation resulting in induction of oedema in other organism" EXACT []
is_a: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism
created_by: janelomax
creation_date: 2011-12-21T03:57:27Z

[Term]
id: GO:0044399
name: multi-species biofilm formation
namespace: biological_process
def: "A process in which planktonically growing microorganisms of different species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription." [GOC:cc, GOC:di, GOC:tb]
subset: gosubset_prok
is_a: GO:0042710 ! biofilm formation
is_a: GO:0044403 ! symbiosis, encompassing mutualism through parasitism

[Term]
id: GO:0044400
name: multi-species biofilm formation on inanimate substrate
namespace: biological_process
def: "A process in which microorganisms of different species attach to and grow on an inanimate surface such as a rock or pipe and produce extracellular polymers that facilitate attachment and matrix formation, resulting in a change in the organisms' growth rate and gene transcription." [GOC:cc]
subset: gosubset_prok
is_a: GO:0090608 ! multi-species submerged biofilm formation

[Term]
id: GO:0044401
name: multi-species biofilm formation in or on host organism
namespace: biological_process
def: "A process in which microorganisms of different species attach to and grow in or on a host species, and produce extracellular polymers that facilitate attachment and matrix formation,  resulting in a change in the microorganisms' growth rate and gene transcription.  The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
is_a: GO:0044406 ! adhesion of symbiont to host
is_a: GO:0090608 ! multi-species submerged biofilm formation

[Term]
id: GO:0044402
name: competition with other organism
namespace: biological_process
def: "Any process in which an organism within a multispecies community gains an advantage in growth or survival over another organism of a different species in that community." [GOC:cc]
subset: gosubset_prok
synonym: "competition with another organism" EXACT [GOC:bf]
synonym: "interspecies competition" BROAD []
is_a: GO:0044419 ! interspecies interaction between organisms

[Term]
id: GO:0044403
name: symbiosis, encompassing mutualism through parasitism
namespace: biological_process
alt_id: GO:0043298
alt_id: GO:0044404
def: "An interaction between two organisms living together in more or less intimate association. Microscopic symbionts are often referred to as endosymbionts. The various forms of symbiosis include parasitism, in which the association is disadvantageous or destructive to one of the organisms; mutualism, in which the association is advantageous, or often necessary to one or both and not harmful to either; and commensalism, in which one member of the association benefits while the other is not affected. However, mutualism, parasitism, and commensalism are often not discrete categories of interactions and should rather be perceived as a continuum of interaction ranging from parasitism to mutualism. In fact, the direction of a symbiotic interaction can change during the lifetime of the symbionts due to developmental changes as well as changes in the biotic/abiotic environment in which the interaction occurs." [GOC:cc, http://www.free-definition.com]
comment: Note that this term encompasses all symbiotic relationships between species along a continuum from mutualism through to parasitism, as outlined in the definition.
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: gosubset_prok
synonym: "host-pathogen interaction" RELATED []
synonym: "symbiosis" EXACT []
synonym: "symbiotic interaction" EXACT []
synonym: "symbiotic interaction between host and organism" RELATED []
synonym: "symbiotic interaction between organisms" EXACT []
synonym: "symbiotic interaction between species" EXACT []
synonym: "symbiotic interaction with other non-host organism" RELATED []
is_a: GO:0044419 ! interspecies interaction between organisms

[Term]
id: GO:0044405
name: recognition of host
namespace: biological_process
def: "The set of specific processes that allow an organism to detect the presence of its host via physical or chemical signals. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
synonym: "detection of host" EXACT []
is_a: GO:0051824 ! recognition of other organism involved in symbiotic interaction
is_a: GO:0075136 ! response to host

[Term]
id: GO:0044406
name: adhesion of symbiont to host
namespace: biological_process
alt_id: GO:0051825
alt_id: GO:0051856
def: "The attachment of a symbiont to its host via adhesion molecules, general stickiness etc., either directly or indirectly. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:bf, GOC:cc, GOC:dos, GOC:jl]
comment: This term can be used to annotate both symbiont and host organisms. Consider also annotating to interaction with host ; GO:0051702, or interaction with symbiont ; GO:0051702.
subset: gosubset_prok
synonym: "adhesion to host" NARROW []
synonym: "adhesion to other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "adhesion to other organism involved in symbiotic interaction" EXACT []
synonym: "adhesion to symbiont" NARROW []
synonym: "host adhesion" NARROW []
is_a: GO:0022610 ! biological adhesion
is_a: GO:0051704 ! multi-organism process
relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism

[Term]
id: GO:0044407
name: single-species biofilm formation in or on host organism
namespace: biological_process
def: "A process in which microorganisms of the same species attach to and grow in or on a host species, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in a change in the microorganisms' growth rate and gene transcription. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
is_a: GO:0044010 ! single-species biofilm formation
is_a: GO:0044406 ! adhesion of symbiont to host

[Term]
id: GO:0044408
name: obsolete growth or development of symbiont on or near host
namespace: biological_process
def: "OBSOLETE. Any process in which the symbiont regulates the increase in its size or mass, or its progression from an initial condition to a later condition, within the cells or tissues of the host organism." [GOC:cc]
comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'growth of symbiont on or near host ; GO:0044133' and 'development of symbiont on or near host ; GO:0044132'.
subset: gosubset_prok
synonym: "growth or development of organism on or near host surface" EXACT []
synonym: "growth or development of symbiont on or near host" EXACT []
is_obsolete: true
consider: GO:0044132
consider: GO:0044133

[Term]
id: GO:0044409
name: entry into host
namespace: biological_process
def: "Penetration by an organism into the body, tissues, or cells of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
synonym: "host invasion" EXACT []
synonym: "invasion into host" EXACT []
synonym: "invasion of host" EXACT []
synonym: "invasive growth" RELATED []
is_a: GO:0051828 ! entry into other organism involved in symbiotic interaction
is_a: GO:0052126 ! movement in host environment

[Term]
id: GO:0044410
name: entry into host through natural portals
namespace: biological_process
def: "Penetration by an organism into its host organism via naturally occurring openings in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
is_a: GO:0044409 ! entry into host
is_a: GO:0051829 ! entry into other organism through natural portals involved in symbiotic interaction

[Term]
id: GO:0044411
name: entry into host through host barriers
namespace: biological_process
def: "Penetration by an organism into its host organism via active breaching of the physical barriers of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
is_a: GO:0044409 ! entry into host
is_a: GO:0051830 ! entry into other organism through barriers of other organism involved in symbiotic interaction

[Term]
id: GO:0044412
name: obsolete growth or development of symbiont in host
namespace: biological_process
def: "OBSOLETE. The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'development of symbiont in host ; GO:0044114' and 'growth of symbiont in host ; GO:0044117'.
subset: gosubset_prok
synonym: "growth or development of organism within host" EXACT []
synonym: "growth or development of symbiont in host" EXACT []
synonym: "growth or development of symbiont within host" EXACT []
synonym: "invasive growth" BROAD []
is_obsolete: true
consider: GO:0044114
consider: GO:0044117

[Term]
id: GO:0044413
name: avoidance of host defenses
namespace: biological_process
def: "Any process, either constitutive or induced, by which an organism evades, suppresses or tolerates the effects of its host organism's defense(s). Host defenses may be induced by the presence of the organism or may be preformed (e.g. physical barriers). The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "avoidance of host defences" EXACT []
is_a: GO:0051832 ! avoidance of defenses of other organism involved in symbiotic interaction
is_a: GO:0052200 ! response to host defenses

[Term]
id: GO:0044414
name: suppression of host defenses
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of host defense(s) by active mechanisms that normally result in the shutting down of a host pathway. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
synonym: "negative regulation of host defenses" EXACT []
is_a: GO:0044413 ! avoidance of host defenses
is_a: GO:0051833 ! suppression of defenses of other organism involved in symbiotic interaction

[Term]
id: GO:0044415
name: evasion or tolerance of host defenses
namespace: biological_process
def: "Any process, either active or passive, by which an organism avoids or tolerates the effects of its host organism's defense(s). Host defenses may be induced by the presence of the organism or may be preformed (e.g. physical barriers). The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
is_a: GO:0044413 ! avoidance of host defenses
is_a: GO:0051834 ! evasion or tolerance of defenses of other organism involved in symbiotic interaction

[Term]
id: GO:0044416
name: induction by symbiont of host defense response
namespace: biological_process
def: "The activation by an organism of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
synonym: "activation of host defense response" EXACT []
is_a: GO:0052251 ! induction by organism of defense response of other organism involved in symbiotic interaction
is_a: GO:0052509 ! positive regulation by symbiont of host defense response

[Term]
id: GO:0044417
name: translocation of molecules into host
namespace: biological_process
def: "The directed movement of a molecule(s) produced by an organism to a location inside its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
synonym: "transport of molecules into host" EXACT []
is_a: GO:0051701 ! interaction with host
is_a: GO:0051836 ! translocation of molecules into other organism involved in symbiotic interaction

[Term]
id: GO:0044418
name: translocation of DNA into host
namespace: biological_process
def: "The directed movement of DNA from an organism to a location inside its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
synonym: "transport of DNA into host" EXACT []
is_a: GO:0044417 ! translocation of molecules into host
is_a: GO:0051837 ! translocation of DNA into other organism involved in symbiotic interaction

[Term]
id: GO:0044419
name: interspecies interaction between organisms
namespace: biological_process
def: "Any process in which an organism has an effect on an organism of a different species." [GOC:cc]
subset: goslim_candida
subset: goslim_pir
subset: gosubset_prok
synonym: "interaction with another species" EXACT []
synonym: "interspecies interaction" EXACT []
synonym: "interspecies interaction with other organisms" EXACT []
is_a: GO:0051704 ! multi-organism process

[Term]
id: GO:0044420
name: extracellular matrix component
namespace: cellular_component
def: "Any constituent part of the extracellular matrix, the structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as often seen in plants)." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: goantislim_grouping
subset: gocheck_do_not_annotate
subset: gosubset_prok
synonym: "extracellular matrix part" EXACT []
is_a: GO:0005575 ! cellular_component
intersection_of: GO:0005575 ! cellular_component
intersection_of: part_of GO:0031012 ! extracellular matrix
relationship: part_of GO:0031012 ! extracellular matrix

[Term]
id: GO:0044421
name: extracellular region part
namespace: cellular_component
def: "Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: goantislim_grouping
subset: gocheck_do_not_annotate
subset: gosubset_prok
synonym: "extracellular structure" RELATED [NIF_Subcellular:sao9117790637]
xref: NIF_Subcellular:sao9117790637
is_a: GO:0005575 ! cellular_component
intersection_of: GO:0005575 ! cellular_component
intersection_of: part_of GO:0005576 ! extracellular region
relationship: part_of GO:0005576 ! extracellular region

[Term]
id: GO:0044422
name: organelle part
namespace: cellular_component
def: "Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: goantislim_grouping
subset: gocheck_do_not_annotate
subset: gosubset_prok
is_a: GO:0005575 ! cellular_component
intersection_of: GO:0005575 ! cellular_component
intersection_of: part_of GO:0043226 ! organelle
relationship: part_of GO:0043226 ! organelle

[Term]
id: GO:0044423
name: virion part
namespace: cellular_component
def: "Any constituent part of a virion, a complete fully infectious extracellular virus particle." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: goantislim_grouping
subset: gocheck_do_not_annotate
is_a: GO:0005575 ! cellular_component
intersection_of: GO:0005575 ! cellular_component
intersection_of: part_of GO:0019012 ! virion
relationship: part_of GO:0019012 ! virion

[Term]
id: GO:0044424
name: intracellular part
namespace: cellular_component
def: "Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: goantislim_grouping
subset: gocheck_do_not_annotate
subset: gosubset_prok
is_a: GO:0044464 ! cell part
intersection_of: GO:0005575 ! cellular_component
intersection_of: part_of GO:0005622 ! intracellular
relationship: part_of GO:0005622 ! intracellular

[Term]
id: GO:0044425
name: membrane part
namespace: cellular_component
def: "Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: goantislim_grouping
subset: gocheck_do_not_annotate
subset: gosubset_prok
is_a: GO:0005575 ! cellular_component
intersection_of: GO:0005575 ! cellular_component
intersection_of: part_of GO:0016020 ! membrane
relationship: part_of GO:0016020 ! membrane

[Term]
id: GO:0044426
name: cell wall part
namespace: cellular_component
def: "Any constituent part of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: goantislim_grouping
subset: gocheck_do_not_annotate
subset: gosubset_prok
is_a: GO:0044462 ! external encapsulating structure part
intersection_of: GO:0005575 ! cellular_component
intersection_of: part_of GO:0005618 ! cell wall
relationship: part_of GO:0005618 ! cell wall

[Term]
id: GO:0044427
name: chromosomal part
namespace: cellular_component
def: "Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: goantislim_grouping
subset: gocheck_do_not_annotate
subset: gosubset_prok
synonym: "chromosomal component" EXACT []
synonym: "chromosome component" EXACT []
synonym: "chromosome part" EXACT []
is_a: GO:0044446 ! intracellular organelle part
intersection_of: GO:0005575 ! cellular_component
intersection_of: part_of GO:0005694 ! chromosome
relationship: part_of GO:0005694 ! chromosome

[Term]
id: GO:0044428
name: nuclear part
namespace: cellular_component
def: "Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: goantislim_grouping
subset: gocheck_do_not_annotate
synonym: "nuclear subcomponent" EXACT [NIF_Subcellular:sao1499850686]
synonym: "nucleus component" EXACT []
xref: NIF_Subcellular:sao1499850686
is_a: GO:0044446 ! intracellular organelle part
intersection_of: GO:0005575 ! cellular_component
intersection_of: part_of GO:0005634 ! nucleus
relationship: part_of GO:0005634 ! nucleus

[Term]
id: GO:0044429
name: mitochondrial part
namespace: cellular_component
def: "Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: goantislim_grouping
subset: gocheck_do_not_annotate
synonym: "mitochondrial subcomponent" EXACT [NIF_Subcellular:sao666410040]
synonym: "mitochondrion component" EXACT []
xref: NIF_Subcellular:sao666410040
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0044446 ! intracellular organelle part
intersection_of: GO:0005575 ! cellular_component
intersection_of: part_of GO:0005739 ! mitochondrion
relationship: part_of GO:0005739 ! mitochondrion

[Term]
id: GO:0044430
name: cytoskeletal part
namespace: cellular_component
def: "Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: goantislim_grouping
subset: gocheck_do_not_annotate
synonym: "cytoskeletal element" EXACT [NIF_Subcellular:sao1635329413]
synonym: "cytoskeleton component" EXACT []
xref: NIF_Subcellular:sao1635329413
is_a: GO:0044446 ! intracellular organelle part
intersection_of: GO:0005575 ! cellular_component
intersection_of: part_of GO:0005856 ! cytoskeleton
relationship: part_of GO:0005856 ! cytoskeleton

[Term]
id: GO:0044431
name: Golgi apparatus part
namespace: cellular_component
def: "Any constituent part of the Golgi apparatus, a compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: goantislim_grouping
subset: gocheck_do_not_annotate
synonym: "Golgi component" EXACT []
synonym: "Golgi subcomponent" EXACT [NIF_Subcellular:sao624292949]
xref: NIF_Subcellular:sao624292949
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0044446 ! intracellular organelle part
intersection_of: GO:0005575 ! cellular_component
intersection_of: part_of GO:0005794 ! Golgi apparatus
relationship: part_of GO:0005794 ! Golgi apparatus

[Term]
id: GO:0044432
name: endoplasmic reticulum part
namespace: cellular_component
def: "Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: goantislim_grouping
subset: gocheck_do_not_annotate
synonym: "ER component" EXACT []
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0044446 ! intracellular organelle part
intersection_of: GO:0005575 ! cellular_component
intersection_of: part_of GO:0005783 ! endoplasmic reticulum
relationship: part_of GO:0005783 ! endoplasmic reticulum

[Term]
id: GO:0044433
name: cytoplasmic vesicle part
namespace: cellular_component
def: "Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: goantislim_grouping
subset: gocheck_do_not_annotate
subset: gosubset_prok
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0044446 ! intracellular organelle part
intersection_of: GO:0005575 ! cellular_component
intersection_of: part_of GO:0031410 ! cytoplasmic vesicle
relationship: part_of GO:0031410 ! cytoplasmic vesicle

[Term]
id: GO:0044434
name: chloroplast part
namespace: cellular_component
def: "Any constituent part of a chloroplast, a chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: goantislim_grouping
subset: gocheck_do_not_annotate
is_a: GO:0044435 ! plastid part
intersection_of: GO:0005575 ! cellular_component
intersection_of: part_of GO:0009507 ! chloroplast
relationship: part_of GO:0009507 ! chloroplast

[Term]
id: GO:0044435
name: plastid part
namespace: cellular_component
def: "Any constituent part of a plastid, a member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: goantislim_grouping
subset: gocheck_do_not_annotate
subset: gosubset_prok
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0044446 ! intracellular organelle part
intersection_of: GO:0005575 ! cellular_component
intersection_of: part_of GO:0009536 ! plastid
relationship: part_of GO:0009536 ! plastid

[Term]
id: GO:0044436
name: thylakoid part
namespace: cellular_component
def: "Any constituent part of a thylakoid, a sac-like vesicle that bears the photosynthetic pigments in photosynthetic organisms." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: goantislim_grouping
subset: gocheck_do_not_annotate
subset: gosubset_prok
is_a: GO:0044424 ! intracellular part
intersection_of: GO:0005575 ! cellular_component
intersection_of: part_of GO:0009579 ! thylakoid
relationship: part_of GO:0009579 ! thylakoid

[Term]
id: GO:0044437
name: vacuolar part
namespace: cellular_component
def: "Any constituent part of a vacuole, a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: goantislim_grouping
subset: gocheck_do_not_annotate
subset: gosubset_prok
synonym: "vacuole component" EXACT []
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0044446 ! intracellular organelle part
intersection_of: GO:0005575 ! cellular_component
intersection_of: part_of GO:0005773 ! vacuole
relationship: part_of GO:0005773 ! vacuole

[Term]
id: GO:0044438
name: microbody part
namespace: cellular_component
def: "Any constituent part of a microbody, a cytoplasmic organelle, spherical or oval in shape, that is bounded by a single membrane and contains oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2)." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: goantislim_grouping
subset: gocheck_do_not_annotate
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0044446 ! intracellular organelle part
intersection_of: GO:0005575 ! cellular_component
intersection_of: part_of GO:0042579 ! microbody
relationship: part_of GO:0042579 ! microbody

[Term]
id: GO:0044439
name: peroxisomal part
namespace: cellular_component
def: "Any constituent part of a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2)." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: goantislim_grouping
subset: gocheck_do_not_annotate
synonym: "peroxisome component" EXACT []
is_a: GO:0044438 ! microbody part
intersection_of: GO:0005575 ! cellular_component
intersection_of: part_of GO:0005777 ! peroxisome
relationship: part_of GO:0005777 ! peroxisome

[Term]
id: GO:0044440
name: endosomal part
namespace: cellular_component
def: "Any constituent part of an endosome, a membrane-bounded organelle to which materials ingested by endocytosis are delivered." [GOC:mah, PMID:19696797]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: goantislim_grouping
subset: gocheck_do_not_annotate
synonym: "endosomal subcomponent" EXACT [NIF_Subcellular:sao1683772610]
synonym: "endosome component" EXACT []
xref: NIF_Subcellular:sao1683772610
is_a: GO:0044437 ! vacuolar part
intersection_of: GO:0005575 ! cellular_component
intersection_of: part_of GO:0005768 ! endosome
relationship: part_of GO:0005768 ! endosome

[Term]
id: GO:0044441
name: ciliary part
namespace: cellular_component
alt_id: GO:0044442
def: "Any constituent part of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. Also note that cilia and eukaryotic flagella are deemed to be equivalent.
subset: goantislim_grouping
subset: gocheck_do_not_annotate
synonym: "cilial part" EXACT []
synonym: "cilium part" EXACT []
synonym: "flagellar part" NARROW []
synonym: "flagellum component" NARROW []
synonym: "flagellum part" NARROW []
synonym: "microtubule-based flagellum part" EXACT []
is_a: GO:0044422 ! organelle part
is_a: GO:0044463 ! cell projection part
intersection_of: GO:0005575 ! cellular_component
intersection_of: part_of GO:0005929 ! cilium
relationship: part_of GO:0005929 ! cilium

[Term]
id: GO:0044443
name: pilus part
namespace: cellular_component
def: "Any constituent part of a pilus, a proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter." [GOC:pamgo_curators]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: goantislim_grouping
subset: gocheck_do_not_annotate
subset: gosubset_prok
synonym: "fimbrial part" EXACT []
synonym: "fimbrium component" EXACT []
synonym: "pilus component" EXACT []
is_a: GO:0044446 ! intracellular organelle part
is_a: GO:0044463 ! cell projection part
intersection_of: GO:0005575 ! cellular_component
intersection_of: part_of GO:0009289 ! pilus
relationship: part_of GO:0009289 ! pilus

[Term]
id: GO:0044444
name: cytoplasmic part
namespace: cellular_component
def: "Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: goantislim_grouping
subset: gocheck_do_not_annotate
subset: gosubset_prok
synonym: "cytoplasm component" EXACT []
is_a: GO:0044424 ! intracellular part
intersection_of: GO:0005575 ! cellular_component
intersection_of: part_of GO:0005737 ! cytoplasm
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0044445
name: cytosolic part
namespace: cellular_component
def: "Any constituent part of cytosol, that part of the cytoplasm that does not contain membranous or particulate subcellular components." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: goantislim_grouping
subset: gocheck_do_not_annotate
subset: gosubset_prok
synonym: "cytosol component" EXACT []
is_a: GO:0044444 ! cytoplasmic part
intersection_of: GO:0005575 ! cellular_component
intersection_of: part_of GO:0005829 ! cytosol
relationship: part_of GO:0005829 ! cytosol

[Term]
id: GO:0044446
name: intracellular organelle part
namespace: cellular_component
def: "A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
subset: gosubset_prok
is_a: GO:0044422 ! organelle part
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0043229 ! intracellular organelle

[Term]
id: GO:0044447
name: axoneme part
namespace: cellular_component
def: "Any constituent part of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:cilia, GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. Also note that cilia and eukaryotic flagella are deemed to be equivalent.
subset: goantislim_grouping
subset: gocheck_do_not_annotate
synonym: "axonemal part" EXACT []
is_a: GO:0044441 ! ciliary part
intersection_of: GO:0005575 ! cellular_component
intersection_of: part_of GO:0005930 ! axoneme
relationship: part_of GO:0005930 ! axoneme

[Term]
id: GO:0044448
name: cell cortex part
namespace: cellular_component
def: "Any constituent part of the cell cortex, the region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: goantislim_grouping
subset: gocheck_do_not_annotate
is_a: GO:0044444 ! cytoplasmic part
intersection_of: GO:0005575 ! cellular_component
intersection_of: part_of GO:0005938 ! cell cortex
relationship: part_of GO:0005938 ! cell cortex

[Term]
id: GO:0044449
name: contractile fiber part
namespace: cellular_component
def: "Any constituent part of a contractile fiber, a fiber composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: goantislim_grouping
subset: gocheck_do_not_annotate
synonym: "contractile fibre component" EXACT []
synonym: "muscle fiber component" BROAD []
synonym: "muscle fibre component" BROAD []
is_a: GO:0044422 ! organelle part
is_a: GO:0044444 ! cytoplasmic part
intersection_of: GO:0005575 ! cellular_component
intersection_of: part_of GO:0043292 ! contractile fiber
relationship: part_of GO:0043292 ! contractile fiber

[Term]
id: GO:0044450
name: microtubule organizing center part
namespace: cellular_component
def: "Any constituent part of a microtubule organizing center, a region in a eukaryotic cell, such as a centrosome or basal body, from which microtubules grow." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: goantislim_grouping
subset: gocheck_do_not_annotate
synonym: "microtubule organizing centre component" EXACT []
synonym: "MTOC component" EXACT []
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044444 ! cytoplasmic part
intersection_of: GO:0005575 ! cellular_component
intersection_of: part_of GO:0005815 ! microtubule organizing center
relationship: part_of GO:0005815 ! microtubule organizing center

[Term]
id: GO:0044451
name: nucleoplasm part
namespace: cellular_component
def: "Any constituent part of the nucleoplasm, that part of the nuclear content other than the chromosomes or the nucleolus." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: goantislim_grouping
subset: gocheck_do_not_annotate
is_a: GO:0044428 ! nuclear part
intersection_of: GO:0005575 ! cellular_component
intersection_of: part_of GO:0005654 ! nucleoplasm
relationship: part_of GO:0005654 ! nucleoplasm

[Term]
id: GO:0044452
name: nucleolar part
namespace: cellular_component
def: "Any constituent part of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: goantislim_grouping
subset: gocheck_do_not_annotate
synonym: "nucleolus component" EXACT []
is_a: GO:0044428 ! nuclear part
intersection_of: GO:0005575 ! cellular_component
intersection_of: part_of GO:0005730 ! nucleolus
relationship: part_of GO:0005730 ! nucleolus

[Term]
id: GO:0044453
name: nuclear membrane part
namespace: cellular_component
def: "Any constituent part of the nuclear membrane, the envelope that surrounds the nucleus of eukaryotic cells." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: goantislim_grouping
subset: gocheck_do_not_annotate
is_a: GO:0044425 ! membrane part
is_a: GO:0044428 ! nuclear part
intersection_of: GO:0005575 ! cellular_component
intersection_of: part_of GO:0031965 ! nuclear membrane
relationship: part_of GO:0031965 ! nuclear membrane

[Term]
id: GO:0044454
name: nuclear chromosome part
namespace: cellular_component
def: "Any constituent part of a nuclear chromosome, a chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: goantislim_grouping
subset: gocheck_do_not_annotate
is_a: GO:0044427 ! chromosomal part
is_a: GO:0044428 ! nuclear part
intersection_of: GO:0005575 ! cellular_component
intersection_of: part_of GO:0000228 ! nuclear chromosome
relationship: part_of GO:0000228 ! nuclear chromosome

[Term]
id: GO:0044455
name: mitochondrial membrane part
namespace: cellular_component
def: "Any constituent part of a mitochondrial membrane, either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: goantislim_grouping
subset: gocheck_do_not_annotate
is_a: GO:0044425 ! membrane part
is_a: GO:0044429 ! mitochondrial part
intersection_of: GO:0005575 ! cellular_component
intersection_of: part_of GO:0031966 ! mitochondrial membrane
relationship: part_of GO:0031966 ! mitochondrial membrane

[Term]
id: GO:0044456
name: synapse part
namespace: cellular_component
def: "Any constituent part of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: goantislim_grouping
subset: gocheck_do_not_annotate
synonym: "synaptic component" RELATED [NIF_Subcellular:sao1784069613]
xref: NIF_Subcellular:sao1784069613
is_a: GO:0005575 ! cellular_component
intersection_of: GO:0005575 ! cellular_component
intersection_of: part_of GO:0045202 ! synapse
relationship: part_of GO:0045202 ! synapse

[Term]
id: GO:0044457
name: cell septum part
namespace: cellular_component
def: "Any constituent part of a cell septum, a structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: goantislim_grouping
subset: gocheck_do_not_annotate
is_a: GO:0044464 ! cell part
intersection_of: GO:0005575 ! cellular_component
intersection_of: part_of GO:0030428 ! cell septum
relationship: part_of GO:0030428 ! cell septum

[Term]
id: GO:0044458
name: motile cilium assembly
namespace: biological_process
def: "The assembly of a motile cilium, a cilium that contains a regular longitudinal array of axonemal microtubules. In vertebrates, motile cilia are usually formed around a 9 + 2 microtubule core structure. Motile cilia are often found in tissues where propagation of fluid is necessary for proper organ development or function." [PMID:21129373, ZFIN:dsf]
is_a: GO:0042384 ! cilium assembly
created_by: janelomax
creation_date: 2012-01-11T03:11:42Z

[Term]
id: GO:0044459
name: plasma membrane part
namespace: cellular_component
def: "Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: goantislim_grouping
subset: gocheck_do_not_annotate
subset: gosubset_prok
is_a: GO:0044425 ! membrane part
is_a: GO:0044464 ! cell part
intersection_of: GO:0005575 ! cellular_component
intersection_of: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0005886 ! plasma membrane

[Term]
id: GO:0044460
name: obsolete flagellum part
namespace: cellular_component
def: "OBSOLETE. Any constituent part of a flagellum, a long whiplike or feathery structure borne either singly or in groups by the motile cells of many bacteria and unicellular eukaryotes and by the motile male gametes of many eukaryotic organisms, which propel the cell through a liquid medium." [GOC:jl]
comment: This term was made obsolete because it was an unnecessary grouping term. Eukaryotic flagella were deemed to be equivalent to cilia and merged, so the only remaining child to this term was 'bacterial-type flagellum part ; GO:0044461'.
subset: gocheck_do_not_annotate
subset: gosubset_prok
synonym: "flagellum component" EXACT []
synonym: "flagellum part" EXACT []
is_obsolete: true
consider: GO:0044441

[Term]
id: GO:0044461
name: bacterial-type flagellum part
namespace: cellular_component
def: "Any constituent part of flagellum, a 20 nm diameter filament composed of subunits of flagellin driven passively at its base by a motor powered by the transmembrane proton potential. Examples of this component are found in bacterial species." [GOC:jl, GOC:mtg_sensu]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: goantislim_grouping
subset: gocheck_do_not_annotate
subset: gosubset_prok
synonym: "flagellin-based flagellum part" EXACT []
is_a: GO:0044422 ! organelle part
is_a: GO:0044424 ! intracellular part
is_a: GO:0044463 ! cell projection part
intersection_of: GO:0005575 ! cellular_component
intersection_of: part_of GO:0009288 ! bacterial-type flagellum
relationship: part_of GO:0009288 ! bacterial-type flagellum

[Term]
id: GO:0044462
name: external encapsulating structure part
namespace: cellular_component
def: "Any constituent part of an external encapsulating structure, a structure that lies outside the plasma membrane and surrounds the entire cell. This does not include the periplasmic space but does include the outer membrane (of gram negative bacteria) or cell wall (of yeast or Gram positive bacteria)." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: goantislim_grouping
subset: gocheck_do_not_annotate
subset: gosubset_prok
is_a: GO:0044464 ! cell part
intersection_of: GO:0005575 ! cellular_component
intersection_of: part_of GO:0030312 ! external encapsulating structure
relationship: part_of GO:0030312 ! external encapsulating structure

[Term]
id: GO:0044463
name: cell projection part
namespace: cellular_component
def: "Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: goantislim_grouping
subset: gocheck_do_not_annotate
subset: gosubset_prok
is_a: GO:0044464 ! cell part
intersection_of: GO:0005575 ! cellular_component
intersection_of: part_of GO:0042995 ! cell projection
relationship: part_of GO:0042995 ! cell projection

[Term]
id: GO:0044464
name: cell part
namespace: cellular_component
def: "Any constituent part of a cell, the basic structural and functional unit of all organisms." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: goantislim_grouping
subset: gocheck_do_not_annotate
subset: goslim_pir
subset: gosubset_prok
synonym: "cellular subcomponent" EXACT [NIF_Subcellular:sao628508602]
synonym: "protoplast" RELATED [GOC:mah]
xref: NIF_Subcellular:sao628508602
is_a: GO:0005575 ! cellular_component
intersection_of: GO:0005575 ! cellular_component
intersection_of: part_of GO:0005623 ! cell
relationship: part_of GO:0005623 ! cell

[Term]
id: GO:0044465
name: modulation of sensory perception of pain in other organism
namespace: biological_process
def: "A process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal, in a different organism." [GOC:ed, PMID:18579526]
synonym: "regulation of sensory perception of pain in another organism" EXACT []
is_a: GO:0035821 ! modification of morphology or physiology of other organism
is_a: GO:0051930 ! regulation of sensory perception of pain
created_by: janelomax
creation_date: 2012-01-12T03:14:19Z

[Term]
id: GO:0044466
name: glutaryl-CoA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: glutaryl-CoA + H2O = CoA + glutarate." [GOC:pm, PMID:16141203]
synonym: "glutaryl-CoA thioesterase activity" EXACT []
xref: EC:3.1.2.-
is_a: GO:0047617 ! acyl-CoA hydrolase activity
created_by: janelomax
creation_date: 2012-01-17T04:16:43Z

[Term]
id: GO:0044467
name: glial cell-derived neurotrophic factor secretion
namespace: biological_process
def: "The regulated release of glial cell line-derived neurotrophic factor from a cell. Glial cell-derived neurotrophic factor (GDNF) is a small protein that potently promotes the survival of many types of neurons, notably dopaminergic and motor neurons." [GOC:yaf, PMID:17505307]
synonym: "GDNF secretion" EXACT []
synonym: "glial cell line-derived neurotrophic factor secretion" RELATED []
is_a: GO:0050663 ! cytokine secretion
created_by: janelomax
creation_date: 2012-01-17T04:26:05Z

[Term]
id: GO:0044468
name: envenomation resulting in modulation of blood coagulation in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the modulation of the frequency, rate or extent of blood coagulation in the bitten organism." [GOC:jl]
synonym: "envenomation resulting in regulation of blood coagulation in other organism" EXACT []
is_a: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism
intersection_of: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism
intersection_of: has_part GO:0035806 ! modulation of blood coagulation in other organism
relationship: has_part GO:0035806 ! modulation of blood coagulation in other organism
created_by: janelomax
creation_date: 2012-01-19T01:24:10Z

[Term]
id: GO:0044469
name: envenomation resulting in positive regulation of blood coagulation in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant activation, maintenance or an increase in the frequency, rate or extent of blood coagulation in the bitten organism." [GOC:jl]
is_a: GO:0044468 ! envenomation resulting in modulation of blood coagulation in other organism
is_a: GO:0044483 ! envenomation resulting in impairment of hemostasis in other organism
relationship: has_part GO:0035807 ! positive regulation of blood coagulation in other organism
created_by: janelomax
creation_date: 2012-01-19T01:29:09Z

[Term]
id: GO:0044470
name: envenomation resulting in negative regulation of blood coagulation in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction in the frequency, rate or extent of blood coagulation in the bitten organism." [GOC:jl]
is_a: GO:0044468 ! envenomation resulting in modulation of blood coagulation in other organism
is_a: GO:0044483 ! envenomation resulting in impairment of hemostasis in other organism
relationship: has_part GO:0035899 ! negative regulation of blood coagulation in other organism
created_by: janelomax
creation_date: 2012-01-19T01:32:48Z

[Term]
id: GO:0044471
name: envenomation resulting in pore formation in membrane of other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the aggregation, arrangement and bonding together of a set of components to form a pore complex in a membrane of the bitten organism." [GOC:fj, GOC:jl, PMID:21549739]
is_a: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism
relationship: has_part GO:0035915 ! pore formation in membrane of other organism
created_by: janelomax
creation_date: 2012-01-19T01:39:47Z

[Term]
id: GO:0044472
name: envenomation resulting in modulation of calcium channel activity in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change in the activity of a calcium channel in the bitten organism." [GOC:fj, GOC:jl, PMID:20920515]
is_a: GO:0044560 ! envenomation resulting in modulation of ion channel activity in other organism
relationship: has_part GO:0035916 ! modulation of calcium channel activity in other organism
created_by: janelomax
creation_date: 2012-01-19T02:17:25Z

[Term]
id: GO:0044473
name: envenomation resulting in negative regulation of calcium channel activity in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction of the activity of a calcium channel in the bitten organism." [GOC:fj, GOC:jl, PMID:20920515]
is_a: GO:0044472 ! envenomation resulting in modulation of calcium channel activity in other organism
relationship: has_part GO:0035917 ! negative regulation of calcium channel activity in other organism
created_by: janelomax
creation_date: 2012-01-19T02:19:46Z

[Term]
id: GO:0044474
name: envenomation resulting in negative regulation of voltage-gated calcium channel activity in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction of the activity of a voltage-gated calcium channel in the bitten organism." [GOC:fj, GOC:jl, PMID:20920515]
is_a: GO:0044473 ! envenomation resulting in negative regulation of calcium channel activity in other organism
relationship: has_part GO:0035918 ! negative regulation of voltage-gated calcium channel activity in other organism
created_by: janelomax
creation_date: 2012-01-19T02:25:04Z

[Term]
id: GO:0044475
name: envenomation resulting in negative regulation of high voltage-gated calcium channel activity in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction of the activity of a high voltage-gated calcium channel in the bitten organism." [GOC:fj, GOC:jl, PMID:20920515]
is_a: GO:0044474 ! envenomation resulting in negative regulation of voltage-gated calcium channel activity in other organism
relationship: has_part GO:0035920 ! negative regulation of high voltage-gated calcium channel activity in other organism
created_by: janelomax
creation_date: 2012-01-19T02:28:11Z

[Term]
id: GO:0044476
name: envenomation resulting in negative regulation of low voltage-gated calcium channel activity in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction of the activity of a low voltage-gated calcium channel in the bitten organism." [GOC:fj, GOC:jl, PMID:20920515]
is_a: GO:0044474 ! envenomation resulting in negative regulation of voltage-gated calcium channel activity in other organism
relationship: has_part GO:0035919 ! negative regulation of low voltage-gated calcium channel activity in other organism
created_by: janelomax
creation_date: 2012-01-19T02:28:42Z

[Term]
id: GO:0044477
name: envenomation resulting in negative regulation of platelet aggregation in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction in the frequency, rate or extent of platelet aggregation in the bitten organism." [GOC:fj, GOC:jl]
is_a: GO:0044365 ! envenomation resulting in modulation of platelet aggregation in other organism
intersection_of: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism
intersection_of: has_part GO:0035893 ! negative regulation of platelet aggregation in other organism
relationship: has_part GO:0035893 ! negative regulation of platelet aggregation in other organism
created_by: janelomax
creation_date: 2012-01-19T02:36:44Z

[Term]
id: GO:0044478
name: envenomation resulting in positive regulation of platelet aggregation in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant activation, maintenance or an increase in the frequency, rate or extent of platelet aggregation in the bitten organism." [GOC:fj, GOC:jl]
is_a: GO:0044365 ! envenomation resulting in modulation of platelet aggregation in other organism
is_a: GO:0044469 ! envenomation resulting in positive regulation of blood coagulation in other organism
intersection_of: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism
intersection_of: has_part GO:0035894 ! positive regulation of platelet aggregation in other organism
relationship: has_part GO:0035807 ! positive regulation of blood coagulation in other organism
relationship: has_part GO:0035894 ! positive regulation of platelet aggregation in other organism
created_by: janelomax
creation_date: 2012-01-19T02:39:45Z

[Term]
id: GO:0044479
name: envenomation resulting in modulation of mast cell degranulation in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of blood mast cell degranulation in the bitten organism." [GOC:fj, GOC:jl, PMID:21549739]
is_a: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism
relationship: has_part GO:0035895 ! modulation of mast cell degranulation in other organism
created_by: janelomax
creation_date: 2012-01-19T02:51:51Z

[Term]
id: GO:0044480
name: envenomation resulting in positive regulation of mast cell degranulation in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of blood mast cell degranulation in the bitten organism." [GOC:fj, GOC:jl, PMID:21549739]
is_a: GO:0044479 ! envenomation resulting in modulation of mast cell degranulation in other organism
relationship: has_part GO:0035896 ! positive regulation of mast cell degranulation in other organism
created_by: janelomax
creation_date: 2012-01-19T02:54:37Z

[Term]
id: GO:0044481
name: envenomation resulting in proteolysis in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant hydrolysis of proteins in of the bitten organism." [GOC:fj, GOC:jl, PMID:15922779]
is_a: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism
relationship: has_part GO:0035897 ! proteolysis in other organism
created_by: janelomax
creation_date: 2012-01-19T03:01:16Z

[Term]
id: GO:0044482
name: envenomation resulting in blood vessel extracellular matrix damage, causing hemorrhagic damage in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism which causes damage to the extracellular matrix of the blood vessels of the bitten organism, ultimately resulting in hemorrhage in the bitten organism." [GOC:fj, GOC:jl, PMID:10441379, PMID:19485419]
synonym: "envenomation resulting in blood vessel ECM, causing hemorrhagic damage in other organism" EXACT []
is_a: GO:0044358 ! envenomation resulting in hemorrhagic damage to other organism
created_by: janelomax
creation_date: 2012-01-19T03:12:04Z

[Term]
id: GO:0044483
name: envenomation resulting in impairment of hemostasis in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the inhibition of the process of hemostasis - the stopping of bleeding or the arrest of the circulation to an organ or part - in the bitten organism." [GOC:fj, GOC:jl]
synonym: "envenomation resulting in negative regulation of hemostasis in other organism" EXACT []
synonym: "envenomation, impairing hemostasis in other organism" EXACT []
is_a: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism
created_by: janelomax
creation_date: 2012-01-19T03:15:56Z

[Term]
id: GO:0044484
name: envenomation resulting in fibrinolysis in other organism
namespace: biological_process
def: "The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with fibrinolysis, a process that solubilizes fibrin, chiefly by the proteolytic action of plasmin, in the bloodstream of the bitten/stung organism." [GOC:fj, GOC:jl, PMID:17433397, PMID:17544404]
is_a: GO:0044483 ! envenomation resulting in impairment of hemostasis in other organism
intersection_of: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism
intersection_of: has_part GO:0042730 ! fibrinolysis
relationship: has_part GO:0042730 ! fibrinolysis
created_by: janelomax
creation_date: 2012-01-26T03:26:33Z

[Term]
id: GO:0044485
name: envenomation resulting in fibrinogenolysis in other organism
namespace: biological_process
def: "The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with fibrinogenolysis, a process that degrades fibrinogen at a variety of Arg-Lys bonds, thus impairing fibrinogen clotting in the bloodstream of the bitten/stung organism." [GOC:fj, GOC:jl, PMID:17433397, PMID:17544404]
is_a: GO:0044536 ! envenomation resulting in depletion of circulating fibrinogen in other organism
created_by: janelomax
creation_date: 2012-01-26T03:41:01Z

[Term]
id: GO:0044486
name: modulation of transmission of nerve impulse in other organism
namespace: biological_process
def: "The process in which an organism effects a change in the transmission of a nerve impulse in another organism." [GOC:jl]
synonym: "modulation of conduction of nerve impulse in other organism" EXACT [GOC:dph]
synonym: "regulation of transmission of nerve impulse in other organism" EXACT []
is_a: GO:0035821 ! modification of morphology or physiology of other organism
is_a: GO:0051969 ! regulation of transmission of nerve impulse
created_by: janelomax
creation_date: 2012-01-26T04:03:31Z

[Term]
id: GO:0044487
name: envenomation resulting in modulation of transmission of nerve impulse in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of the transmission of nerve impulses in the bitten organism." [GOC:fj, GOC:jl]
synonym: "envenomation resulting in modulation of conduction of nerve impulse in other organism" EXACT [GOC:dph]
is_a: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism
relationship: has_part GO:0044486 ! modulation of transmission of nerve impulse in other organism
created_by: janelomax
creation_date: 2012-01-26T05:01:54Z

[Term]
id: GO:0044488
name: modulation of voltage-gated sodium channel activity in other organism
namespace: biological_process
def: "Any process in which an organism effects a change in the frequency, rate or extent of the activity of a voltage-gated sodium channel in another organism." [GOC:fj, GOC:jl, PMID:21781281]
is_a: GO:0044561 ! modulation of ion channel activity in other organism
created_by: janelomax
creation_date: 2012-02-01T11:48:25Z

[Term]
id: GO:0044489
name: negative regulation of voltage-gated sodium channel activity in other organism
namespace: biological_process
def: "Any process in which an organism effects a change in the frequency, rate or extent of the activity of a voltage-gated sodium channel in another organism." [GOC:fj, GOC:jl, PMID:21781281]
is_a: GO:0044362 ! negative regulation of molecular function in other organism
is_a: GO:0044488 ! modulation of voltage-gated sodium channel activity in other organism
created_by: janelomax
creation_date: 2012-02-01T12:21:02Z

[Term]
id: GO:0044490
name: positive regulation of voltage-gated sodium channel activity in other organism
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the activity of a voltage-gated sodium channel in another organism." [GOC:fj, GOC:jl, PMID:21781281]
is_a: GO:0044488 ! modulation of voltage-gated sodium channel activity in other organism
is_a: GO:0044491 ! positive regulation of molecular function in other organism
created_by: janelomax
creation_date: 2012-02-01T12:21:26Z

[Term]
id: GO:0044491
name: positive regulation of molecular function in other organism
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the function of proteins in a second organism." [GOC:jl]
is_a: GO:0044092 ! negative regulation of molecular function
is_a: GO:0044093 ! positive regulation of molecular function
is_a: GO:0044359 ! modulation of molecular function in other organism
created_by: janelomax
creation_date: 2012-02-01T12:21:51Z

[Term]
id: GO:0044492
name: envenomation resulting in modulation of voltage-gated sodium channel activity in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change in the activity of a voltage-gated sodium channel in the bitten organism." [GOC:fj, GOC:jl, PMID:21781281]
is_a: GO:0044560 ! envenomation resulting in modulation of ion channel activity in other organism
relationship: has_part GO:0044488 ! modulation of voltage-gated sodium channel activity in other organism
created_by: janelomax
creation_date: 2012-02-01T01:23:04Z

[Term]
id: GO:0044493
name: envenomation resulting in negative regulation of voltage-gated sodium channel activity in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction of the activity of a voltage-gated sodium channel in the bitten organism." [GOC:fj, GOC:jl, PMID:21781281]
is_a: GO:0044492 ! envenomation resulting in modulation of voltage-gated sodium channel activity in other organism
relationship: has_part GO:0044489 ! negative regulation of voltage-gated sodium channel activity in other organism
created_by: janelomax
creation_date: 2012-02-01T01:26:59Z

[Term]
id: GO:0044494
name: envenomation resulting in positive regulation of voltage-gated sodium channel activity in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant activation or increase in the activity of the activity of a voltage-gated sodium channel in the bitten organism." [GOC:fj, GOC:jl, PMID:21781281]
is_a: GO:0044492 ! envenomation resulting in modulation of voltage-gated sodium channel activity in other organism
relationship: has_part GO:0044490 ! positive regulation of voltage-gated sodium channel activity in other organism
created_by: janelomax
creation_date: 2012-02-01T01:29:25Z

[Term]
id: GO:0044495
name: modulation of blood pressure in other organism
namespace: biological_process
def: "A process by which one organism modulates the force with which blood travels through the circulatory system of another organism." [GOC:fj, GOC:jl, PMID:19837656]
synonym: "regulation of blood pressure in other organism" EXACT []
is_a: GO:0008217 ! regulation of blood pressure
created_by: janelomax
creation_date: 2012-02-01T02:10:15Z

[Term]
id: GO:0044496
name: negative regulation of blood pressure in other organism
namespace: biological_process
def: "A process by which one organism decreases the force with which blood travels through the circulatory system of another organism." [GOC:fj, GOC:jl, PMID:19837656]
is_a: GO:0044495 ! modulation of blood pressure in other organism
is_a: GO:0045776 ! negative regulation of blood pressure
created_by: janelomax
creation_date: 2012-02-01T02:15:28Z

[Term]
id: GO:0044497
name: positive regulation of blood pressure in other organism
namespace: biological_process
def: "A process by which one organism increases the force with which blood travels through the circulatory system of another organism." [GOC:fj, GOC:jl, PMID:19837656]
is_a: GO:0044495 ! modulation of blood pressure in other organism
is_a: GO:0045777 ! positive regulation of blood pressure
created_by: janelomax
creation_date: 2012-02-01T02:17:21Z

[Term]
id: GO:0044498
name: envenomation resulting in modulation of blood pressure in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of the force with which blood travels through the circulatory system of the bitten/stung organism." [GOC:fj, GOC:jl, PMID:19837656]
synonym: "envenomation resulting in regulation of blood pressure in other organism" EXACT []
is_a: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism
intersection_of: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism
intersection_of: has_part GO:0044495 ! modulation of blood pressure in other organism
relationship: has_part GO:0044495 ! modulation of blood pressure in other organism
created_by: janelomax
creation_date: 2012-02-01T02:21:27Z

[Term]
id: GO:0044499
name: envenomation resulting in positive regulation of blood pressure in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant increase of the force with which blood travels through the circulatory system of the bitten/stung organism." [GOC:fj, GOC:jl, PMID:19837656]
is_a: GO:0044498 ! envenomation resulting in modulation of blood pressure in other organism
relationship: has_part GO:0044497 ! positive regulation of blood pressure in other organism
created_by: janelomax
creation_date: 2012-02-01T02:39:06Z

[Term]
id: GO:0044500
name: envenomation resulting in negative regulation of blood pressure in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant decrease of the force with which blood travels through the circulatory system of the bitten/stung organism." [GOC:fj, GOC:jl, PMID:19837656]
synonym: "hypotensive activity in other organism" EXACT []
is_a: GO:0044498 ! envenomation resulting in modulation of blood pressure in other organism
relationship: has_part GO:0044496 ! negative regulation of blood pressure in other organism
created_by: janelomax
creation_date: 2012-02-01T02:40:50Z

[Term]
id: GO:0044501
name: modulation of signal transduction in other organism
namespace: biological_process
def: "The process in which an organism effects a change in a signal transduction process - a cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell - in a second organism." [GOC:fj, GOC:jl]
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0035821 ! modification of morphology or physiology of other organism
created_by: janelomax
creation_date: 2012-02-23T03:48:19Z

[Term]
id: GO:0044502
name: positive regulation of signal transduction in other organism
namespace: biological_process
def: "A process in which an organism activates, maintains or increases the frequency, rate or extent of a signal transduction process - a cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell - in a second organism." [GOC:fj, GOC:jl]
is_a: GO:0044501 ! modulation of signal transduction in other organism
created_by: janelomax
creation_date: 2012-02-23T04:00:28Z

[Term]
id: GO:0044503
name: modulation of G-protein coupled receptor activity in other organism
namespace: biological_process
def: "The process in which an organism effects a change in the activity of a G-protein coupled receptor in a second organism." [GOC:fj, GOC:jl, PMID:8405712]
is_a: GO:0044504 ! modulation of receptor activity in other organism
created_by: janelomax
creation_date: 2012-02-23T04:20:07Z

[Term]
id: GO:0044504
name: modulation of receptor activity in other organism
namespace: biological_process
def: "The process in which an organism effects a change in the activity of a receptor in a second organism." [GOC:fj, GOC:jl, PMID:8405712]
is_a: GO:0010469 ! regulation of receptor activity
is_a: GO:0044359 ! modulation of molecular function in other organism
created_by: janelomax
creation_date: 2012-02-23T04:21:41Z

[Term]
id: GO:0044505
name: positive regulation of G-protein coupled receptor activity in other organism
namespace: biological_process
def: "A process that activates or increases the frequency, rate or extent of the activity of a G-protein coupled receptor in a second organism." [GOC:fj, GOC:jl, PMID:8405712]
synonym: "regulation of G-protein coupled receptor activity in other organism" EXACT []
is_a: GO:0044503 ! modulation of G-protein coupled receptor activity in other organism
is_a: GO:0044507 ! positive regulation of receptor activity in other organism
is_a: GO:2000273 ! positive regulation of receptor activity
created_by: janelomax
creation_date: 2012-02-23T04:24:17Z

[Term]
id: GO:0044506
name: modulation of glucagon-like peptide receptor 1 activity in other organism
namespace: biological_process
def: "The process in which an organism effects a change in the activity of a glucagon-like peptide receptor 1 in a second organism." [GOC:fj, GOC:jl, PMID:8405712]
synonym: "regulation of glucagon-like peptide receptor activity in other organism" EXACT []
is_a: GO:0044504 ! modulation of receptor activity in other organism
created_by: janelomax
creation_date: 2012-02-23T04:29:14Z

[Term]
id: GO:0044507
name: positive regulation of receptor activity in other organism
namespace: biological_process
def: "A process that activates or increases the frequency, rate or extent of the activity of a receptor in a second organism." [GOC:fj, GOC:jl, PMID:8405712]
is_a: GO:0044491 ! positive regulation of molecular function in other organism
is_a: GO:0044504 ! modulation of receptor activity in other organism
created_by: janelomax
creation_date: 2012-02-23T04:31:52Z

[Term]
id: GO:0044508
name: glucagon-like peptide 1 receptor activity
namespace: molecular_function
def: "Combining with glucagon-like peptide 1 and transmitting the signal across the membrane by activating an associated G-protein." [GOC:jl, PMID:12529935]
is_a: GO:0008528 ! G-protein coupled peptide receptor activity
created_by: janelomax
creation_date: 2012-02-23T04:50:25Z

[Term]
id: GO:0044509
name: envenomation resulting in modulation of signal transduction in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of signal transduction in the bitten organism." [GOC:fj, GOC:jl, PMID:8405712]
is_a: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism
relationship: has_part GO:0044501 ! modulation of signal transduction in other organism
created_by: janelomax
creation_date: 2012-02-23T04:58:10Z

[Term]
id: GO:0044510
name: envenomation resulting in positive regulation of signal transduction in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of signal transduction in the bitten organism." [GOC:fj, GOC:jl, PMID:8405712]
is_a: GO:0044509 ! envenomation resulting in modulation of signal transduction in other organism
relationship: has_part GO:0044502 ! positive regulation of signal transduction in other organism
created_by: janelomax
creation_date: 2012-02-23T05:03:22Z

[Term]
id: GO:0044511
name: envenomation resulting in modulation of receptor activity in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of receptor activity in of the bitten organism." [GOC:fj, GOC:jl, PMID:8405712]
is_a: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism
relationship: has_part GO:0044504 ! modulation of receptor activity in other organism
created_by: janelomax
creation_date: 2012-02-26T10:12:24Z

[Term]
id: GO:0044512
name: envenomation resulting in modulation of glucagon-like peptide receptor 1 activity in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of glucagon-like peptide receptor 1 activity in of the bitten organism." [GOC:fj, GOC:jl, PMID:8405712]
is_a: GO:0044511 ! envenomation resulting in modulation of receptor activity in other organism
relationship: has_part GO:0044506 ! modulation of glucagon-like peptide receptor 1 activity in other organism
created_by: janelomax
creation_date: 2012-02-26T10:20:19Z

[Term]
id: GO:0044513
name: envenomation resulting in modulation of G-protein coupled receptor activity in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of G-protein coupled receptor activity in of the bitten organism." [GOC:fj, GOC:jl, PMID:8405712]
is_a: GO:0044511 ! envenomation resulting in modulation of receptor activity in other organism
relationship: has_part GO:0044503 ! modulation of G-protein coupled receptor activity in other organism
created_by: janelomax
creation_date: 2012-02-26T11:02:17Z

[Term]
id: GO:0044514
name: envenomation resulting in positive regulation of G-protein coupled receptor activity in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of G-protein coupled receptor activity in of the bitten organism." [GOC:fj, GOC:jl, PMID:8405712]
is_a: GO:0044513 ! envenomation resulting in modulation of G-protein coupled receptor activity in other organism
relationship: has_part GO:0044505 ! positive regulation of G-protein coupled receptor activity in other organism
created_by: janelomax
creation_date: 2012-02-26T11:06:15Z

[Term]
id: GO:0044515
name: envenomation resulting in positive regulation of glucagon-like peptide receptor 1 activity in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of glucagon-like peptide receptor 1 activity in of the bitten organism." [GOC:fj, GOC:jl, PMID:8405712]
is_a: GO:0044512 ! envenomation resulting in modulation of glucagon-like peptide receptor 1 activity in other organism
relationship: has_part GO:0044516 ! positive regulation of glucagon-like peptide receptor 1 activity in other organism
created_by: janelomax
creation_date: 2012-02-26T11:08:08Z

[Term]
id: GO:0044516
name: positive regulation of glucagon-like peptide receptor 1 activity in other organism
namespace: biological_process
def: "A process that activates or increases the frequency, rate or extent of the activity of a glucagon-like peptide receptor 1 in a second organism." [GOC:fj, GOC:jl, PMID:8405712]
is_a: GO:0044506 ! modulation of glucagon-like peptide receptor 1 activity in other organism
is_a: GO:0044507 ! positive regulation of receptor activity in other organism
created_by: janelomax
creation_date: 2012-02-26T11:09:44Z

[Term]
id: GO:0044517
name: modulation of vasoactive intestinal polypeptide receptor activity in other organism
namespace: biological_process
def: "The process in which an organism effects a change in the activity of a vasoactive intestinal polypeptide receptor in a second organism." [GOC:fj, GOC:jl]
synonym: "modulation of VIP receptor activity in other organism" EXACT []
synonym: "regulation of vasoactive intestinal polypeptide receptor activity in other organism" EXACT []
is_a: GO:0044504 ! modulation of receptor activity in other organism
created_by: janelomax
creation_date: 2012-02-26T11:48:32Z

[Term]
id: GO:0044518
name: positive regulation of vasoactive intestinal polypeptide receptor activity in other organism
namespace: biological_process
def: "A process that activates or increases the frequency, rate or extent of the activity of a vasoactive intestinal polypeptide receptor in a second organism." [GOC:fj, GOC:jl]
synonym: "positive regulation of VIP receptor activity in other organism" EXACT []
is_a: GO:0044507 ! positive regulation of receptor activity in other organism
is_a: GO:0044517 ! modulation of vasoactive intestinal polypeptide receptor activity in other organism
created_by: janelomax
creation_date: 2012-02-26T11:50:34Z

[Term]
id: GO:0044519
name: envenomation resulting in modulation of vasoactive intestinal polypeptide receptor activity in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of the activity of a vasoactive intestinal polypeptide receptor in the bitten organism." [GOC:fj, GOC:jl]
synonym: "envenomation resulting in modulation of VIP receptor activity in other organism" EXACT []
synonym: "envenomation resulting in regulation of vasoactive intestinal polypeptide receptor activity in other organism" EXACT []
synonym: "envenomation resulting in regulation of VIP receptor activity in other organism" EXACT []
is_a: GO:0044511 ! envenomation resulting in modulation of receptor activity in other organism
relationship: has_part GO:0044517 ! modulation of vasoactive intestinal polypeptide receptor activity in other organism
created_by: janelomax
creation_date: 2012-02-26T11:53:33Z

[Term]
id: GO:0044520
name: envenomation resulting in positive regulation of vasoactive intestinal polypeptide receptor activity in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of the activity of a vasoactive intestinal polypeptide receptor in the bitten organism." [GOC:fj, GOC:jl]
synonym: "envenomation resulting in positive regulation of VIP receptor activity in other organism" EXACT []
is_a: GO:0044519 ! envenomation resulting in modulation of vasoactive intestinal polypeptide receptor activity in other organism
relationship: has_part GO:0044518 ! positive regulation of vasoactive intestinal polypeptide receptor activity in other organism
created_by: janelomax
creation_date: 2012-02-26T11:55:46Z

[Term]
id: GO:0044521
name: envenomation resulting in muscle damage in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with resultant muscle damage in the bitten organism." [GOC:fj, GOC:jl, PMID:10620318, PMID:21150580]
is_a: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism
created_by: janelomax
creation_date: 2012-02-27T12:31:08Z

[Term]
id: GO:0044522
name: envenomation resulting in myocyte killing in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, killing heart myocytes and ultimately resulting in muscle damage in the bitten organism." [GOC:fj, GOC:jl, PMID:10620318, PMID:21150580]
synonym: "envenomation resulting in myocyte killing causing muscle damage in other organism" EXACT []
is_a: GO:0044521 ! envenomation resulting in muscle damage in other organism
created_by: janelomax
creation_date: 2012-02-27T12:33:57Z

[Term]
id: GO:0044523
name: envenomation resulting in damage of muscle extracellular matrix in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, damaging the extracellular matrix of muscle cells and ultimately resulting in muscle necrosis in the bitten organism." [GOC:fj, GOC:jl, PMID:10620318, PMID:21150580]
synonym: "envenomation resulting in damage of muscle extracellular matrix causing muscle necrosis in other organism" EXACT []
is_a: GO:0044521 ! envenomation resulting in muscle damage in other organism
created_by: janelomax
creation_date: 2012-02-27T12:40:32Z

[Term]
id: GO:0044524
name: protein sulfhydration
namespace: biological_process
def: "The modification of a protein amino acid by the addition of sulfur." [GOC:jl, GOC:jsg, PMID:19903941, PMID:22169477, PMID:8161529]
is_a: GO:0006464 ! cellular protein modification process
created_by: janelomax
creation_date: 2012-03-15T09:39:33Z

[Term]
id: GO:0044525
name: peptidyl-cystine sulfhydration
namespace: biological_process
def: "The modification of a peptidyl-cystine residue in a protein by the addition of sulfur, to form peptidyl-cysteine persulfide." [GOC:jl, GOC:jsg]
is_a: GO:0044524 ! protein sulfhydration
created_by: janelomax
creation_date: 2012-03-15T09:44:07Z

[Term]
id: GO:0044526
name: formation of peptidyl-cystine persulfide by sulphur transfer from free cysteine
namespace: biological_process
def: "The modification of a peptidyl-cystine residue in a protein by the transfer of a sulfur atom from a free cysteine (in the process converting the free cysteine to alanine) to the peptidyl-cysteine to form peptidyl-cysteine persulfide." [GOC:jl, GOC:jsg]
is_a: GO:0044525 ! peptidyl-cystine sulfhydration
created_by: janelomax
creation_date: 2012-03-15T09:45:19Z

[Term]
id: GO:0044527
name: formation of peptidyl-cystine persulfide by sulphur transfer from H2S
namespace: biological_process
def: "The modification of a peptidyl-cystine residue in a protein by the direct addition of H2S, followed by the removal of 2 protons to form peptidyl-cysteine persulfide." [GOC:jl, GOC:jsg]
is_a: GO:0044525 ! peptidyl-cystine sulfhydration
created_by: janelomax
creation_date: 2012-03-15T09:46:23Z

[Term]
id: GO:0044528
name: regulation of mitochondrial mRNA stability
namespace: biological_process
def: "Any process that modulates the propensity of mitochondrial mRNA molecules to degradation. Includes processes that both stabilize and destabilize mitochondrial mRNAs." [GOC:al, GOC:jl]
is_a: GO:0043488 ! regulation of mRNA stability
created_by: janelomax
creation_date: 2012-03-15T03:20:10Z

[Term]
id: GO:0044529
name: regulation of mitochondrial rRNA stability
namespace: biological_process
def: "Any process that modulates the propensity of mitochondrial rRNA molecules to degradation. Includes processes that both stabilize and destabilize mitochondrial rRNAs." [GOC:al, GOC:jl]
subset: gosubset_prok
is_a: GO:0044357 ! regulation of rRNA stability
created_by: janelomax
creation_date: 2012-03-15T03:22:19Z

[Term]
id: GO:0044530
name: supraspliceosomal complex
namespace: cellular_component
def: "Multicomponent complex of RNA and proteins that is composed of four active spliceosomes, termed native spliceosomes, connected to each other by the pre-mRNA. The supraspliceosome is the nuclear machine where the pre-mRNA processing takes place, like the 5'-end capping, 3'-end cleavage, splicing and editing." [GOC:ans, GOC:jl, PMID:19282290]
synonym: "supraspliceosome complex" EXACT []
is_a: GO:0005681 ! spliceosomal complex
created_by: janelomax
creation_date: 2012-03-15T03:33:08Z

[Term]
id: GO:0044531
name: modulation of programmed cell death in other organism
namespace: biological_process
def: "A process in which an organism modulates the frequency, rate or extent of programmed cell death in a second organism." [GOC:jl]
is_a: GO:0035821 ! modification of morphology or physiology of other organism
is_a: GO:0043067 ! regulation of programmed cell death
created_by: janelomax
creation_date: 2012-03-20T04:48:41Z

[Term]
id: GO:0044532
name: modulation of apoptotic process in other organism
namespace: biological_process
def: "A process in which an organism modulates the frequency, rate or extent of apoptosis in a second organism." [GOC:jl]
synonym: "regulation of apoptotic process in other organism" EXACT []
is_a: GO:0042981 ! regulation of apoptotic process
is_a: GO:0044531 ! modulation of programmed cell death in other organism
created_by: janelomax
creation_date: 2012-03-21T11:17:18Z

[Term]
id: GO:0044533
name: positive regulation of apoptotic process in other organism
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death by apoptosis in a second organism." [GOC:jl, PMID:17983639]
subset: gosubset_prok
is_a: GO:0043065 ! positive regulation of apoptotic process
is_a: GO:0044532 ! modulation of apoptotic process in other organism
created_by: janelomax
creation_date: 2012-03-21T11:25:24Z

[Term]
id: GO:0044534
name: envenomation resulting in modulation of apoptotic process in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of apoptosis in the bitten organism." [GOC:fj, GOC:jl, PMID:17983639]
is_a: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism
intersection_of: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism
intersection_of: has_part GO:0044532 ! modulation of apoptotic process in other organism
relationship: has_part GO:0044532 ! modulation of apoptotic process in other organism
created_by: janelomax
creation_date: 2012-03-21T11:39:44Z

[Term]
id: GO:0044535
name: very-long-chain fatty acyl-CoA oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: very-long-chain fatty acyl-CoA (C22 - C24) + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide." [PMID:17458872]
subset: gosubset_prok
synonym: "very long chain fatty-acyl-CoA oxidase activity" EXACT []
synonym: "very-long-chain acyl-CoA oxidase activity" EXACT []
synonym: "VLC fatty-acyl-CoA oxidase activity" EXACT []
xref: EC:1.3.3.-
is_a: GO:0003997 ! acyl-CoA oxidase activity
created_by: janelomax
creation_date: 2012-03-21T02:04:42Z

[Term]
id: GO:0044536
name: envenomation resulting in depletion of circulating fibrinogen in other organism
namespace: biological_process
def: "The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with a reduction in the quantity of fibrinogen found in the bloodstream of the bitten/stung organism." [GOC:fj, GOC:jl]
synonym: "envenomation resulting in negative regulation of circulating fibrinogen in other organism" EXACT []
is_a: GO:0044483 ! envenomation resulting in impairment of hemostasis in other organism
is_a: GO:0061754 ! negative regulation of circulating fibrinogen levels
created_by: janelomax
creation_date: 2012-03-21T02:56:49Z

[Term]
id: GO:0044537
name: regulation of circulating fibrinogen levels
namespace: biological_process
def: "Any process that modulates the quantity of fibrinogen circulating in the bloodstream." [GOC:jl]
is_a: GO:0065008 ! regulation of biological quality
created_by: janelomax
creation_date: 2012-03-21T03:15:09Z

[Term]
id: GO:0044538
name: host cell periphery
namespace: cellular_component
def: "The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures of a host cell." [GOC:jl, PMID:20463076]
is_a: GO:0033643 ! host cell part
created_by: janelomax
creation_date: 2012-03-21T03:26:33Z

[Term]
id: GO:0044539
name: long-chain fatty acid import
namespace: biological_process
def: "The directed movement of long-chain fatty acids into a cell or organelle. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [GOC:jl, GOC:pm, PMID:22022213]
synonym: "long-chain fatty acid uptake" EXACT []
is_a: GO:0015909 ! long-chain fatty acid transport
created_by: janelomax
creation_date: 2012-03-21T03:34:04Z

[Term]
id: GO:0044540
name: L-cystine L-cysteine-lyase (deaminating)
namespace: molecular_function
def: "Catalysis of the reaction: L-cystine + H2O <=> pyruvate + NH3 + thiocysteine. Thiocysteine is also known as cysteine persulfide." [GOC:jl, RHEA:24930]
xref: EC:4.4.1.1
xref: KEGG:R02408
xref: RHEA:24930
is_a: GO:0016846 ! carbon-sulfur lyase activity
created_by: janelomax
creation_date: 2012-03-22T11:33:32Z

[Term]
id: GO:0044541
name: zymogen activation in other organism
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the proteolytic processing of an inactive enzyme to an active form in another organism." [GOC:fj, GOC:jl]
is_a: GO:0031638 ! zymogen activation
is_a: GO:0044033 ! multi-organism metabolic process
created_by: janelomax
creation_date: 2012-03-22T11:39:41Z

[Term]
id: GO:0044542
name: plasminogen activation in other organism
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the processing of inactive plasminogen to active plasmin in another organism." [GOC:fj, GOC:jl]
is_a: GO:0031639 ! plasminogen activation
is_a: GO:0044541 ! zymogen activation in other organism
created_by: janelomax
creation_date: 2012-03-22T11:40:03Z

[Term]
id: GO:0044543
name: envenomation resulting in zymogen activation in other organism
namespace: biological_process
def: "The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with the proteolytic processing of an inactive enzyme to an active form." [GOC:fj, GOC:jl]
is_a: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism
relationship: has_part GO:0044541 ! zymogen activation in other organism
created_by: janelomax
creation_date: 2012-03-22T11:52:56Z

[Term]
id: GO:0044544
name: envenomation resulting in plasminogen activation in other organism
namespace: biological_process
def: "The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with the activation of plasminogen into plasmin in the bitten organism. This process includes cleavage at an internal Arg-Val site to form an N-terminal A-chain and C-terminal B-chain held together by a disulfide bond, and can include further proteolytic cleavage events to remove the preactivation peptide." [GOC:fj, GOC:jl]
is_a: GO:0044484 ! envenomation resulting in fibrinolysis in other organism
intersection_of: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism
intersection_of: has_part GO:0042730 ! fibrinolysis
intersection_of: has_part GO:0044542 ! plasminogen activation in other organism
relationship: has_part GO:0042730 ! fibrinolysis
relationship: has_part GO:0044542 ! plasminogen activation in other organism
created_by: janelomax
creation_date: 2012-03-22T11:54:49Z

[Term]
id: GO:0044545
name: NSL complex
namespace: cellular_component
def: "A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residues at several positions. In human, it contains the catalytic subunit MOF, NSL1/KIAA1267, NSL2/KANSL2, NSL3/KANSL3, MCRS1, PHF20, OGT1, WDR5 and HCF1." [GOC:lb, PMID:20018852]
synonym: "non-specific lethal complex" EXACT []
is_a: GO:0000123 ! histone acetyltransferase complex
created_by: janelomax
creation_date: 2012-03-22T12:49:18Z

[Term]
id: GO:0044546
name: NLRP3 inflammasome complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the NLRP3 inflammasome complex, occurring at the level of an individual cell." [GOC:jl, PMID:21048113]
synonym: "NALP3 inflammasome complex assembly" EXACT []
synonym: "NLRP3 inflammasome activation" RELATED []
is_a: GO:0043623 ! cellular protein complex assembly
created_by: janelomax
creation_date: 2012-03-22T01:27:21Z

[Term]
id: GO:0044547
name: DNA topoisomerase binding
namespace: molecular_function
alt_id: GO:0017033
def: "Interacting selectively and non-covalently with a DNA topoisomerase." [GOC:jl]
synonym: "DNA topoisomerase I binding" NARROW []
is_a: GO:0019899 ! enzyme binding
created_by: janelomax
creation_date: 2012-03-22T02:30:37Z

[Term]
id: GO:0044548
name: S100 protein binding
namespace: molecular_function
alt_id: GO:0048154
alt_id: GO:0048155
def: "Interacting selectively and non-covalently with a S100 protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS." [GOC:jid]
synonym: "S100 alpha binding" NARROW []
synonym: "S100 beta binding" NARROW []
synonym: "S100 binding" EXACT []
is_a: GO:0005515 ! protein binding
created_by: janelomax
creation_date: 2012-03-22T03:23:51Z

[Term]
id: GO:0044549
name: GTP cyclohydrolase binding
namespace: molecular_function
alt_id: GO:0043106
def: "Interacting selectively and non-covalently with a GTP cyclohydrolase." [GOC:jl]
synonym: "GTP cyclohydrolase I binding" NARROW []
is_a: GO:0019899 ! enzyme binding
created_by: janelomax
creation_date: 2012-03-22T04:38:14Z

[Term]
id: GO:0044550
name: secondary metabolite biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon." [GOC:jl]
subset: gosubset_prok
synonym: "secondary metabolite biosynthesis" EXACT []
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0044711 ! single-organism biosynthetic process
created_by: janelomax
creation_date: 2012-03-29T01:55:18Z

[Term]
id: GO:0044551
name: envenomation resulting in modulation of vasodilation in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with resultant modulation of vasodilation of blood vessels, usually causing a reduction in blood pressure, in the bitten/stung organism." [GOC:ecd, GOC:jl, PMID:21050868]
synonym: "envenomation resulting in regulation of vasodilation in other organism" EXACT []
is_a: GO:0044500 ! envenomation resulting in negative regulation of blood pressure in other organism
relationship: has_part GO:0044552 ! modulation of vasodilation in other organism
created_by: janelomax
creation_date: 2012-03-29T02:07:45Z

[Term]
id: GO:0044552
name: modulation of vasodilation in other organism
namespace: biological_process
def: "A process by which an organism causes vasodilation of blood vessels, usually causing a reduction in blood pressure, in another organism." [GOC:ecd, GOC:jl, PMID:21050868]
synonym: "regulation of vasodilation in other organism" EXACT []
is_a: GO:0042312 ! regulation of vasodilation
is_a: GO:0044553 ! modulation of biological quality in other organism
is_a: GO:0044706 ! multi-multicellular organism process
created_by: janelomax
creation_date: 2012-03-29T02:14:42Z

[Term]
id: GO:0044553
name: modulation of biological quality in other organism
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a biological quality in another organism. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:jl]
synonym: "regulation of biological quality in other organism" EXACT []
is_a: GO:0035821 ! modification of morphology or physiology of other organism
created_by: janelomax
creation_date: 2012-03-29T02:35:03Z

[Term]
id: GO:0044554
name: modulation of heart rate in other organism
namespace: biological_process
def: "Any process that modulates the frequency or rate of heart contraction of another organism." [GOC:jl, PMID:20923766]
synonym: "regulation of heart rate in other organism" EXACT []
is_a: GO:0002027 ! regulation of heart rate
is_a: GO:0044553 ! modulation of biological quality in other organism
created_by: janelomax
creation_date: 2012-03-29T02:59:43Z

[Term]
id: GO:0044555
name: negative regulation of heart rate in other organism
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency of heart contraction of another organism." [GOC:ecd, GOC:jl, PMID:20923766]
is_a: GO:0010459 ! negative regulation of heart rate
is_a: GO:0044554 ! modulation of heart rate in other organism
created_by: janelomax
creation_date: 2012-03-29T03:01:20Z

[Term]
id: GO:0044556
name: envenomation resulting in negative regulation of heart rate of other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the negative regulation of the heart rate of the bitten/stung organism." [GOC:ecd, GOC:jl, PMID:20923766]
is_a: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism
relationship: has_part GO:0044555 ! negative regulation of heart rate in other organism
created_by: janelomax
creation_date: 2012-03-29T03:04:52Z

[Term]
id: GO:0044557
name: relaxation of smooth muscle
namespace: biological_process
def: "A process in which the extent of smooth muscle contraction is reduced. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length." [GOC:jl]
synonym: "smooth muscle relaxation" EXACT []
is_a: GO:0090075 ! relaxation of muscle
created_by: janelomax
creation_date: 2012-04-05T02:42:28Z

[Term]
id: GO:0044558
name: uterine smooth muscle relaxation
namespace: biological_process
def: "A process in which the extent of smooth muscle contraction is reduced in the uterus." [GOC:jl]
synonym: "smooth muscle relaxation of the uterus" EXACT []
is_a: GO:0044557 ! relaxation of smooth muscle
created_by: janelomax
creation_date: 2012-04-05T02:57:11Z

[Term]
id: GO:0044559
name: envenomation resulting in modulation of voltage-gated potassium channel activity in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change in the activity of a voltage-gated potassium channel in the bitten/stung organism." [GOC:fj, GOC:jl]
is_a: GO:0044560 ! envenomation resulting in modulation of ion channel activity in other organism
relationship: has_part GO:0044360 ! modulation of voltage-gated potassium channel activity in other organism
created_by: janelomax
creation_date: 2012-04-05T03:35:20Z

[Term]
id: GO:0044560
name: envenomation resulting in modulation of ion channel activity in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change in the activity of an ion channel in the bitten organism." [GOC:fj, GOC:jl]
synonym: "envenomation resulting in regulation of ion channel activity in other organism" EXACT []
is_a: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism
relationship: has_part GO:0044561 ! modulation of ion channel activity in other organism
created_by: janelomax
creation_date: 2012-04-05T03:46:35Z

[Term]
id: GO:0044561
name: modulation of ion channel activity in other organism
namespace: biological_process
def: "Any process in which an organism effects a change in the frequency, rate or extent of the activity of an ion channel in another organism." [GOC:jl]
synonym: "regulation of ion channel activity in other organism" EXACT []
is_a: GO:0032409 ! regulation of transporter activity
is_a: GO:0044359 ! modulation of molecular function in other organism
created_by: janelomax
creation_date: 2012-04-05T03:48:28Z

[Term]
id: GO:0044562
name: envenomation resulting in negative regulation of voltage-gated potassium channel activity in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant negative regulation of the activity of a voltage-gated potassium channel in the bitten/stung organism." [GOC:fj, GOC:jl]
is_a: GO:0044559 ! envenomation resulting in modulation of voltage-gated potassium channel activity in other organism
relationship: has_part GO:0044361 ! negative regulation of voltage-gated potassium channel activity in other organism
created_by: janelomax
creation_date: 2012-04-05T04:01:49Z

[Term]
id: GO:0044563
name: envenomation resulting in slowing of activation kinetics of voltage-gated potassium channel in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant slowing of the activation kinetics of the activity of a voltage-gated potassium channel in the bitten/stung organism." [GOC:fj, GOC:jl]
synonym: "voltage-dependence of activation shift (to the left)" EXACT []
is_a: GO:0044562 ! envenomation resulting in negative regulation of voltage-gated potassium channel activity in other organism
created_by: janelomax
creation_date: 2012-04-05T04:06:29Z

[Term]
id: GO:0044564
name: envenomation resulting in occlusion of the pore of voltage-gated potassium channel in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant blocking of a voltage-gated potassium channel, inhibiting the pore's activity, in the bitten/stung organism." [GOC:fj, GOC:jl]
is_a: GO:0044562 ! envenomation resulting in negative regulation of voltage-gated potassium channel activity in other organism
created_by: janelomax
creation_date: 2012-04-05T04:14:24Z

[Term]
id: GO:0044565
name: dendritic cell proliferation
namespace: biological_process
def: "The expansion of a dendritic cell population by cell division. A dendritic cell is a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation." [CL:0000451, PMID:18469816]
is_a: GO:0046651 ! lymphocyte proliferation
created_by: janelomax
creation_date: 2012-04-05T04:31:39Z

[Term]
id: GO:0044566
name: chondrocyte activation
namespace: biological_process
def: "A change in the morphology or behavior of a chondrocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. A chondrocyte is a polymorphic cell that forms cartilage." [CL:0000138, GOC:jl]
is_a: GO:0001775 ! cell activation
created_by: janelomax
creation_date: 2012-04-05T04:45:38Z

[Term]
id: GO:0044567
name: primary cell wall cellulose synthase complex
namespace: cellular_component
def: "A large, multimeric protein complex which catalyzes the biosynthesis of cellulose for the plant primary cell wall. In Arabidopsis, contains the essential component proteins CESA1 and -3, and a CESA6-related protein." [GOC:mengo_curators, GOC:tt, PMID:17878302, PMID:21307367]
synonym: "primary cell wall CESA complex" EXACT []
synonym: "primary cell-wall cellulose synthase complex" EXACT []
is_a: GO:0010330 ! cellulose synthase complex
created_by: janelomax
creation_date: 2012-04-18T12:24:16Z

[Term]
id: GO:0044568
name: secondary cell wall cellulose synthase complex
namespace: cellular_component
def: "A large, multimeric protein complex which catalyzes the biosynthesis of cellulose for the plant secondary cell wall. In Arabidopsis, contains the essential component proteins CESA8, CESA7, and CESA4." [GOC:mengo_curators, GOC:tt, PMID:21307367]
synonym: "secondary cell wall CESA complex" EXACT []
synonym: "secondary cell wall CesA complex" EXACT []
synonym: "secondary cell-wall cellulose synthase complex" EXACT []
is_a: GO:0010330 ! cellulose synthase complex
created_by: janelomax
creation_date: 2012-04-18T12:55:04Z

[Term]
id: GO:0044569
name: [Ni-Fe] hydrogenase complex
namespace: cellular_component
def: "A microbial enzyme complex which contains nickel and iron in its active site. In Acetomicrobium flavidum it is an alpha 2 beta 2 tetramer." [GOC:mengo_curators, GOC:tt, PMID:8936309]
synonym: "Ni-Fe hydrogenase complex" EXACT []
synonym: "nickel-iron hydrogenase complex" EXACT []
is_a: GO:1902494 ! catalytic complex
created_by: janelomax
creation_date: 2012-04-18T01:26:35Z

[Term]
id: GO:0044570
name: starch utilization system complex
namespace: cellular_component
def: "A bacterial cell envelope-associated multiprotein system, which binds and degrades starch." [GOC:mengo_curators, GOC:tt, PMID:19553672]
synonym: "Sus complex" EXACT []
is_a: GO:0044462 ! external encapsulating structure part
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0009279 ! cell outer membrane
created_by: janelomax
creation_date: 2012-04-18T02:46:24Z

[Term]
id: GO:0044571
name: [2Fe-2S] cluster assembly
namespace: biological_process
def: "The incorporation of two iron atoms and two sulfur atoms into an iron-sulfur cluster." [GOC:jl, GOC:mengo_curators, GOC:pde, GOC:tt, GOC:vw, PMID:15952888]
synonym: "2Fe-2S cluster assembly" EXACT []
synonym: "[2Fe-2S] cluster biosynthetic process" RELATED []
is_a: GO:0016226 ! iron-sulfur cluster assembly
created_by: janelomax
creation_date: 2012-04-18T03:06:30Z

[Term]
id: GO:0044572
name: [4Fe-4S] cluster assembly
namespace: biological_process
def: "The incorporation of four iron atoms and four sulfur atoms into an iron-sulfur cluster." [GOC:jl, GOC:mengo_curators, GOC:pde, GOC:tt, GOC:vw, PMID:15952888]
synonym: "4Fe-4S cluster assembly" EXACT []
synonym: "[4Fe-4S] cluster biosynthetic process" RELATED []
is_a: GO:0016226 ! iron-sulfur cluster assembly
created_by: janelomax
creation_date: 2012-04-18T03:19:23Z

[Term]
id: GO:0044573
name: nitrogenase P cluster assembly
namespace: biological_process
def: "The biochemical reactions and pathways resulting in the formation of a P-cluster of a nitrogenase, a high-nuclearity, Fe/S-only cluster that can be viewed as two [4Fe-4S] sub-clusters sharing a gamma-6-sulfide." [PMID:17563349]
synonym: "nitrogenase P cluster biosynthesis" EXACT []
synonym: "nitrogenase P cluster maturation" EXACT []
is_a: GO:0016226 ! iron-sulfur cluster assembly
created_by: janelomax
creation_date: 2012-04-18T03:29:04Z

[Term]
id: GO:0044574
name: starch utilization system complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of the starch utilization system complex, a complex of cell envelope-associated proteins that degrades glycan." [GOC:mengo_curators, GOC:tt, PMID:19553672, PMID:21219452]
synonym: "assembly of starch utilization system complex" EXACT []
synonym: "SUS complex assembly" EXACT []
is_a: GO:0006461 ! protein complex assembly
created_by: janelomax
creation_date: 2012-04-19T03:40:24Z

[Term]
id: GO:0044575
name: cellulosome assembly
namespace: biological_process
def: "The assembly of a cellulosome, a macromolecular multi-enzyme complex in bacteria that facilitates the breakdown of cellulase, hemicellulase and pectin in the plant cell wall." [GOC:mengo_curators, GOC:tt, PMID:20373916]
is_a: GO:0070925 ! organelle assembly
created_by: janelomax
creation_date: 2012-04-19T03:42:36Z

[Term]
id: GO:0044576
name: pentose catabolic process to ethanol
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of a pentose, any monosaccharide with a chain of five carbons, where one of the resulting products is ethanol." [GOC:mengo_curators, GOC:tt]
synonym: "pentose catabolism to ethanol" EXACT []
is_a: GO:0006115 ! ethanol biosynthetic process
is_a: GO:0019323 ! pentose catabolic process
created_by: janelomax
creation_date: 2012-04-19T03:46:37Z

[Term]
id: GO:0044577
name: xylose catabolic process to ethanol
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of xylose, an aldopentose, where one of the resulting products is ethanol." [GOC:mengo_curators, GOC:tt]
synonym: "xylose catabolism to ethanol" EXACT []
is_a: GO:0042843 ! D-xylose catabolic process
is_a: GO:0044576 ! pentose catabolic process to ethanol
created_by: janelomax
creation_date: 2012-04-19T03:50:46Z

[Term]
id: GO:0044578
name: butyryl-CoA biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathway resulting in the formation of butyryl-CoA." [GOC:jl]
synonym: "butyryl-CoA biosynthesis" EXACT []
is_a: GO:0006633 ! fatty acid biosynthetic process
is_a: GO:0046949 ! fatty-acyl-CoA biosynthetic process
created_by: janelomax
creation_date: 2012-04-19T04:23:26Z

[Term]
id: GO:0044579
name: butyryl-CoA biosynthetic process from acetyl-CoA
namespace: biological_process
def: "The chemical reactions and pathway resulting in the formation of butyryl-CoA, starting from acetyl-CoA." [GOC:mengo_curators, GOC:tt, PMID:19539744]
synonym: "butyryl-CoA biosynthesis from acetyl-CoA" EXACT []
is_a: GO:0006084 ! acetyl-CoA metabolic process
is_a: GO:0044578 ! butyryl-CoA biosynthetic process
created_by: janelomax
creation_date: 2012-04-19T04:25:07Z

[Term]
id: GO:0044580
name: butyryl-CoA catabolic process
namespace: biological_process
def: "The chemical reactions a resulting in the resulting in the breakdown of butyryl-CoA." [GOC:jl]
synonym: "butyryl-CoA catabolism" EXACT []
is_a: GO:0009062 ! fatty acid catabolic process
is_a: GO:0036115 ! fatty-acyl-CoA catabolic process
created_by: janelomax
creation_date: 2012-04-19T04:28:46Z

[Term]
id: GO:0044581
name: butyryl-CoA catabolic process to butyrate
namespace: biological_process
def: "The chemical reactions a resulting in the resulting in the breakdown of butyryl-CoA to form butyrate." [GOC:mengo_curators, GOC:tt, PMID:19539744]
synonym: "butyryl-CoA catabolism to butyrate" EXACT []
is_a: GO:0044580 ! butyryl-CoA catabolic process
is_a: GO:0046358 ! butyrate biosynthetic process
created_by: janelomax
creation_date: 2012-04-19T04:29:40Z

[Term]
id: GO:0044582
name: butyryl-CoA catabolic process to butanol
namespace: biological_process
def: "The chemical reactions a resulting in the resulting in the breakdown of butyryl-CoA to form butanol." [GOC:mengo_curators, GOC:tt, PMID:19539744]
synonym: "butyryl-CoA catabolism to butanol" EXACT []
is_a: GO:0044580 ! butyryl-CoA catabolic process
is_a: GO:0071271 ! 1-butanol biosynthetic process
created_by: janelomax
creation_date: 2012-04-19T04:40:06Z

[Term]
id: GO:0044583
name: cellotriose binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with cellotriose." [GOC:mengo_curators, GOC:tt]
is_a: GO:0048031 ! trisaccharide binding
created_by: janelomax
creation_date: 2012-04-24T04:48:01Z

[Term]
id: GO:0044584
name: cellodextrin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with cellodextrin, a glucose polymer of 2 or more glucose monomers." [GOC:mengo_curators, GOC:tt, PMID:18952792]
is_a: GO:0030247 ! polysaccharide binding
is_a: GO:0070492 ! oligosaccharide binding
created_by: janelomax
creation_date: 2012-04-24T04:52:05Z

[Term]
id: GO:0044585
name: cellobiose binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with cellobiose, a disaccharide that represents the basic repeating unit of cellulose." [GOC:mengo_curators, GOC:tt]
is_a: GO:0048030 ! disaccharide binding
created_by: janelomax
creation_date: 2012-04-24T04:55:10Z

[Term]
id: GO:0044586
name: cellotetraose binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with cellotetraose, an oligosaccharide consisting of four glucose residues resulting from hydrolysis of cellulose." [GOC:mengo_curators, GOC:tt]
is_a: GO:0070492 ! oligosaccharide binding
created_by: janelomax
creation_date: 2012-04-24T04:56:10Z

[Term]
id: GO:0044587
name: cellopentaose binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with cellopentaose, an oligosaccharide consisting of four glucose residues resulting from hydrolysis of cellulose." [GOC:mengo_curators, GOC:tt]
is_a: GO:0070492 ! oligosaccharide binding
created_by: janelomax
creation_date: 2012-04-24T04:57:01Z

[Term]
id: GO:0044588
name: laminaribiose binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with laminaribiose, a disaccharide." [GOC:mengo_curators, GOC:tt]
is_a: GO:0070492 ! oligosaccharide binding
created_by: janelomax
creation_date: 2012-04-26T01:19:40Z

[Term]
id: GO:0044589
name: pectin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with pectin." [GOC:mengo_curators, GOC:tt]
is_a: GO:0048028 ! galacturonan binding
created_by: janelomax
creation_date: 2012-04-26T01:26:56Z

[Term]
id: GO:0044590
name: iron-sulfur-molybdenum cofactor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with iron molybdenum cofactor, the cofactor located at the active site of the molybdenum nitrogenase." [GOC:mengo_curators, GOC:tt, PMID:18429691]
synonym: "FeMo co binding" EXACT []
synonym: "FeMoco binding" EXACT []
is_a: GO:0048037 ! cofactor binding
created_by: janelomax
creation_date: 2012-04-26T02:27:39Z

[Term]
id: GO:0044591
name: response to amylopectin
namespace: biological_process
def: "A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of amylopectin stimulus." [GOC:mengo_curators, GOC:tt]
is_a: GO:0010033 ! response to organic substance
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: janelomax
creation_date: 2012-04-26T03:20:03Z

[Term]
id: GO:0044592
name: response to pullulan
namespace: biological_process
def: "A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of pullulan stimulus." [GOC:mengo_curators, GOC:tt]
is_a: GO:0009743 ! response to carbohydrate
created_by: janelomax
creation_date: 2012-04-26T03:59:06Z

[Term]
id: GO:0044593
name: iron-sulfur-molybdenum cofactor assembly
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of iron-sulfur-molybdenum cofactor, the cofactor located at the active site of the molybdenum nitrogenase." [GOC:mengo_curators, GOC:tt, PMID:18429691]
synonym: "FeMoco assembly" EXACT []
synonym: "FeMoco biosynthetic process" EXACT []
synonym: "iron molybdenum cofactor assembly" EXACT []
synonym: "iron molybdenum cofactor biosynthesis" EXACT []
synonym: "iron molybdenum cofactor biosynthetic process" EXACT []
is_a: GO:0051188 ! cofactor biosynthetic process
created_by: janelomax
creation_date: 2012-04-26T04:01:53Z

[Term]
id: GO:0044594
name: 17-beta-hydroxysteroid dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: a 17-beta-hydroxysteroid + NAD+ = a 17-oxosteroid + NADH + H+." [PMID:17074428]
xref: RHEA:24615
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
created_by: janelomax
creation_date: 2012-04-26T04:49:13Z

[Term]
id: GO:0044595
name: decaprenyldihydroxybenzoate methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3-decaprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-decaprenyl-4-hydroxy-5-methoxybenzoate." [PMID:10777520]
is_a: GO:0010420 ! polyprenyldihydroxybenzoate methyltransferase activity
created_by: janelomax
creation_date: 2012-04-26T04:52:05Z

[Term]
id: GO:0044596
name: 3-demethylubiquinone-10 3-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinone-10 = S-adenosyl-L-homocysteine + ubiquinone-10." [PMID:10777520]
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
is_a: GO:0061542 ! 3-demethylubiquinone-n 3-O-methyltransferase activity
created_by: janelomax
creation_date: 2012-04-26T04:54:11Z

[Term]
id: GO:0044597
name: daunorubicin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving daunorubicin, a chemotherapeutic of the anthracycline family that is given as a treatment for some types of cancer." [CHEBI:41977]
is_a: GO:0030638 ! polyketide metabolic process
is_a: GO:0030647 ! aminoglycoside antibiotic metabolic process
is_a: GO:0097164 ! ammonium ion metabolic process
is_a: GO:1901661 ! quinone metabolic process
created_by: janelomax
creation_date: 2012-05-01T03:09:51Z

[Term]
id: GO:0044598
name: doxorubicin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving doxorubicin, an anthracycline antibiotic, used in cancer chemotherapy." [CHEBI:28748]
is_a: GO:0016137 ! glycoside metabolic process
is_a: GO:0030638 ! polyketide metabolic process
is_a: GO:0097164 ! ammonium ion metabolic process
is_a: GO:1901661 ! quinone metabolic process
created_by: janelomax
creation_date: 2012-05-01T03:30:21Z

[Term]
id: GO:0044599
name: AP-5 adaptor complex
namespace: cellular_component
def: "An AP-type membrane coat adaptor complex that in humans consists of beta5, zeta, mu5 and sigma5 subunits and is found associated with membranes in the endosomes; it is not clear whether AP-5 forms clathrin coats in vivo." [PMID:22022230]
synonym: "adaptor protein-5 adaptor complex" EXACT []
is_a: GO:0030119 ! AP-type membrane coat adaptor complex
created_by: janelomax
creation_date: 2012-05-01T03:48:11Z

[Term]
id: GO:0044600
name: protein guanylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP + protein = diphosphate + guanylyl-protein; mediates the addition of an guanylyl (guanosine 5'-monophosphate; GMP group) to specific residues of target proteins." [GOC:sp, PMID:20651120]
is_a: GO:0070568 ! guanylyltransferase activity
relationship: part_of GO:0018260 ! protein guanylylation
created_by: janelomax
creation_date: 2012-05-01T04:00:34Z

[Term]
id: GO:0044601
name: protein denucleotidylation
namespace: biological_process
def: "The removal of a nucleotide from a protein amino acid." [GOC:sp, PMID:21734656]
is_a: GO:0006464 ! cellular protein modification process
created_by: janelomax
creation_date: 2012-05-01T04:13:54Z

[Term]
id: GO:0044602
name: protein deadenylylation
namespace: biological_process
def: "The removal of an adenylyl group (adenosine 5'-monophosphate; AMP) from a protein amino acid." [GOC:sp, PMID:21734656]
synonym: "protein deAMPylation" EXACT [PMID:21734656]
is_a: GO:0044601 ! protein denucleotidylation
created_by: janelomax
creation_date: 2012-05-01T04:16:22Z

[Term]
id: GO:0044603
name: protein adenylylhydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: adenylyl-protein+ H2O = adenylate + protein; mediates the removal of an adenylyl (adenosine 5'-monophosphate; AMP group) from specific residues of target proteins." [PMID:21734656]
synonym: "protein deAMPylase activity" EXACT [PMID:21734656]
synonym: "protein deAMPylation activity" EXACT [PMID:21734656]
is_a: GO:0008081 ! phosphoric diester hydrolase activity
relationship: part_of GO:0018117 ! protein adenylylation
relationship: part_of GO:0044602 ! protein deadenylylation
created_by: janelomax
creation_date: 2012-05-01T04:18:07Z

[Term]
id: GO:0044604
name: phytochelatin transmembrane transporter ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O + phytochelatin (in) = ADP + phosphate + phytochelatin (out)." [GOC:al, PMID:7876244]
synonym: "cadystin transmembrane transporter ATPase activity" RELATED [GOC:vw, http://en.wikipedia.org/wiki/Phytochelatin#History]
is_a: GO:0015440 ! peptide-transporting ATPase activity
is_a: GO:0071992 ! phytochelatin transmembrane transporter activity
created_by: janelomax
creation_date: 2012-05-24T04:29:56Z

[Term]
id: GO:0044605
name: phosphocholine transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CDP-choline + protein-serine = CMP + protein-serine-choline phosphate." [GOC:sp, PMID:21822290]
xref: EC:2.7.1.-
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
created_by: janelomax
creation_date: 2012-05-24T04:44:25Z

[Term]
id: GO:0044606
name: phosphocholine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein-serine-choline phosphate + H2O = protein-serine + choline phosphate." [GOC:sp, PMID:22158903]
xref: EC:3.6.1.-
is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
created_by: janelomax
creation_date: 2012-05-24T04:46:44Z

[Term]
id: GO:0044607
name: disruption by symbiont of host endothelial cells
namespace: biological_process
def: "Any process in which an organism has a negative effect on the functioning of the host's endothelial cells." [GOC:jl]
is_a: GO:0044004 ! disruption by symbiont of host cell
created_by: janelomax
creation_date: 2012-05-30T02:24:50Z

[Term]
id: GO:0044608
name: peptidyl-L-threonine methyl ester biosynthetic process from peptidyl-threonine
namespace: biological_process
def: "The modification of a C-terminal peptidyl-threonine to form peptidyl-L-threonine methyl ester." [RESID:AA0507]
synonym: "peptidyl-threonine esterification" EXACT []
xref: RESID:AA0507
is_a: GO:0006481 ! C-terminal protein methylation
is_a: GO:0018350 ! protein esterification
created_by: janelomax
creation_date: 2012-05-30T02:47:57Z

[Term]
id: GO:0044609
name: DBIRD complex
namespace: cellular_component
def: "A protein complex that associates with mRNP particles and RNA polymerase II and is proposed to integrate transcript elongation with the regulation of alternative splicing. In humans it is composed of the proteins KIAA1967/DBC1 and ZNF326/ZIRD." [GOC:sp, PMID:22446626]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
created_by: janelomax
creation_date: 2012-05-30T03:04:23Z

[Term]
id: GO:0044610
name: FMN transmembrane transporter activity
namespace: molecular_function
def: "Enables the directed movement of flavine mononucleotide (FMN) into, out of or within a cell, or between cells." [GOC:ans, PMID:22185573]
synonym: "flavine mononucleotide transmembrane transporter activity" EXACT []
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015215 ! nucleotide transmembrane transporter activity
is_a: GO:1901505 ! carbohydrate derivative transporter activity
created_by: janelomax
creation_date: 2012-05-30T03:09:19Z

[Term]
id: GO:0044611
name: nuclear pore inner ring
namespace: cellular_component
def: "A subcomplex of the nuclear pore complex (NPC) that forms the inner rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two inner rings are each composed of Nup192p, Nup188p, Nup170p and Nup157p. In vertebrates, the two inner rings are each composed of Nup205, Nup188 and Nup155. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup170 complex." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]
synonym: "Nup170 complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0005643 ! nuclear pore
created_by: janelomax
creation_date: 2012-06-20T01:14:17Z

[Term]
id: GO:0044612
name: nuclear pore linkers
namespace: cellular_component
def: "A substructure of the nuclear pore complex (NPC) that serves to connect members of the central transport channel (composed of FG-nucleoporins) to the core scaffold (composed of the inner and outer NPC rings). In S. cerevisiae, the linkers are Nic96p and Nup82p. In vertebrates, they are Nup93 and Nup88. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. Both linkers can be isolated in association with specific FG-nucleoporins, complexes that are sometimes referred to as the Nic96 complex (Nic96p-Nsp1p-Nup49p-Nup57p) and the Nup82 complex (Nup82p-Nup116p-Nup159p-Gle2p)." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]
synonym: "Nic96 complex" RELATED []
synonym: "Nup82 complex" RELATED []
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0005643 ! nuclear pore
created_by: janelomax
creation_date: 2012-06-20T01:22:40Z

[Term]
id: GO:0044613
name: nuclear pore central transport channel
namespace: cellular_component
def: "The central substructure of the nuclear pore complex (NPC), through which nucleocytoplasmic transport of RNAs, proteins and small molecules occurs. The central transport channel is filled with FG-nucleoporins, which form a selective barrier and provide a series of binding sites for transporter proteins. Characterized S. cerevisiae FG-nucleoporins include Nup159p, Nup145Np, Nup116p, Nup100p, Nsp1p, Nup57p, Nup49p, Nup42p, Nup53p, Nup59p/Asm4p, Nup60p and Nup1. Characterized vertebrate FG-nucleoporins include Nup214, Nup98, Nup62, Nup54, Nup58/45, NLP1, and Nup153." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]
synonym: "karyopherin docking complex" RELATED []
synonym: "nuclear pore central channel" EXACT []
synonym: "nuclear pore central plug" EXACT []
synonym: "nuclear pore transport channel" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0005643 ! nuclear pore
created_by: janelomax
creation_date: 2012-06-20T01:25:30Z

[Term]
id: GO:0044614
name: nuclear pore cytoplasmic filaments
namespace: cellular_component
def: "Filamentous extensions on cytoplasmic face of the nuclear pore complex (NPC). In S. cerevisiae, Nup159p, Nup82p, and Nup42p contribute to the cytoplasmic filaments. In vertebrates, Nup358 is a major component." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]
synonym: "cytoplasmic fibers of the NPC" EXACT [PMID:7775481, PMID:8978815, PMID:9456312]
synonym: "cytoplasmic fibers of the nuclear pore complex" EXACT [PMID:7775481, PMID:8978815, PMID:9456312]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0005643 ! nuclear pore
created_by: janelomax
creation_date: 2012-06-20T01:28:18Z

[Term]
id: GO:0044615
name: nuclear pore nuclear basket
namespace: cellular_component
def: "A filamentous, cage-like assembly on the nuclear face of the nuclear pore complex (NPC). In S. cerevisiae, Mlp1p and Mlp2p are two major components of the NPC nuclear basket. In vertebrates, Tpr is a major component." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0005643 ! nuclear pore
created_by: janelomax
creation_date: 2012-06-20T01:31:01Z

[Term]
id: GO:0044616
name: modulation of relaxation of muscle in other organism
namespace: biological_process
def: "The process in which an organism effects a change in the relaxation of muscle in a second organism." [GOC:jl]
synonym: "regulation of relaxation of muscle in other organism" EXACT []
is_a: GO:0035821 ! modification of morphology or physiology of other organism
is_a: GO:1901077 ! regulation of relaxation of muscle
created_by: janelomax
creation_date: 2012-07-04T01:54:12Z

[Term]
id: GO:0044617
name: modulation of relaxation of smooth muscle in other organism
namespace: biological_process
def: "The process in which an organism effects a change in the relaxation of smooth muscle in a second organism." [GOC:jl]
synonym: "regulation of relaxation of smooth muscle in other organism" EXACT []
is_a: GO:0044616 ! modulation of relaxation of muscle in other organism
is_a: GO:1901080 ! regulation of relaxation of smooth muscle
created_by: janelomax
creation_date: 2012-07-04T01:55:37Z

[Term]
id: GO:0044618
name: modulation of relaxation of uterine smooth muscle in other organism
namespace: biological_process
def: "The process in which an organism effects a change in the relaxation of smooth muscle in the uterus of a second organism." [GOC:jl]
synonym: "regulation of relaxation of uterine smooth muscle in other organism" EXACT []
is_a: GO:0044617 ! modulation of relaxation of smooth muscle in other organism
is_a: GO:1900719 ! regulation of uterine smooth muscle relaxation
created_by: janelomax
creation_date: 2012-07-04T01:56:04Z

[Term]
id: GO:0044619
name: positive regulation of relaxation of uterine smooth muscle in other organism
namespace: biological_process
def: "The process in which an organism effects a change in the relaxation of smooth muscle in the uterus of a second organism." [GOC:jl]
is_a: GO:0044618 ! modulation of relaxation of uterine smooth muscle in other organism
is_a: GO:1900721 ! positive regulation of uterine smooth muscle relaxation
created_by: janelomax
creation_date: 2012-07-04T02:51:26Z

[Term]
id: GO:0044620
name: ACP phosphopantetheine attachment site binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the attachment site of the phosphopantetheine prosthetic group of an acyl carrier protein (ACP)." [GOC:jl, GOC:vw]
is_a: GO:0051192 ! prosthetic group binding
created_by: janelomax
creation_date: 2012-07-04T03:25:04Z

[Term]
id: GO:0044621
name: modulation of cell migration in other organism
namespace: biological_process
def: "The process in which an organism effects a change in the process of cell migration in a second organism." [GOC:jl]
synonym: "regulation of cell migration in other organism" EXACT []
is_a: GO:0030334 ! regulation of cell migration
is_a: GO:0035821 ! modification of morphology or physiology of other organism
created_by: janelomax
creation_date: 2012-07-04T04:40:13Z

[Term]
id: GO:0044622
name: negative regulation of cell migration in other organism
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration in a second organism." [GOC:jl]
is_a: GO:0030336 ! negative regulation of cell migration
is_a: GO:0044621 ! modulation of cell migration in other organism
created_by: janelomax
creation_date: 2012-07-04T04:42:14Z

[Term]
id: GO:0044623
name: positive regulation of cell migration in other organism
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell migration in a second organism." [GOC:jl]
is_a: GO:0030335 ! positive regulation of cell migration
is_a: GO:0044621 ! modulation of cell migration in other organism
created_by: janelomax
creation_date: 2012-07-04T04:44:59Z

[Term]
id: GO:0044624
name: envenomation resulting in modulation of cell migration in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the modulation of cell migration in the bitten organism." [GOC:jl, PMID:19932752]
synonym: "envenomation resulting in regulation of cell migration in other organism" EXACT []
is_a: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism
intersection_of: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism
intersection_of: has_part GO:0044621 ! modulation of cell migration in other organism
relationship: has_part GO:0044621 ! modulation of cell migration in other organism
created_by: janelomax
creation_date: 2012-07-04T05:03:56Z

[Term]
id: GO:0044625
name: envenomation resulting in negative regulation of cell migration in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the negative regulation of cell migration in the bitten organism." [GOC:jl, PMID:19932752]
is_a: GO:0044624 ! envenomation resulting in modulation of cell migration in other organism
relationship: has_part GO:0044622 ! negative regulation of cell migration in other organism
created_by: janelomax
creation_date: 2012-07-04T05:07:16Z

[Term]
id: GO:0044626
name: envenomation resulting in positive regulation of cell migration in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the positive regulation of cell migration in the bitten organism." [GOC:jl, PMID:19932752]
is_a: GO:0044624 ! envenomation resulting in modulation of cell migration in other organism
relationship: has_part GO:0044623 ! positive regulation of cell migration in other organism
created_by: janelomax
creation_date: 2012-07-04T05:08:21Z

[Term]
id: GO:0044627
name: modulation of complement activation, classical pathway in other organism
namespace: biological_process
def: "A process that modulates the frequency, rate or extent of the classical pathway of complement activation, in a different organism." [GOC:jl, PMID:20837040]
synonym: "regulation of complement activation, classical pathway in other organism" EXACT []
is_a: GO:0030450 ! regulation of complement activation, classical pathway
is_a: GO:0044645 ! modulation of complement activation in other organism
created_by: janelomax
creation_date: 2012-07-05T12:55:53Z

[Term]
id: GO:0044628
name: positive regulation of complement activation, classical pathway in other organism
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of complement activation by the classical pathway, in a different organism." [GOC:jl, PMID:20837040]
is_a: GO:0044627 ! modulation of complement activation, classical pathway in other organism
is_a: GO:0045960 ! positive regulation of complement activation, classical pathway
created_by: janelomax
creation_date: 2012-07-05T01:00:10Z

[Term]
id: GO:0044629
name: negative regulation of complement activation, classical pathway in other organism
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the classical pathway, in a different organism." [GOC:jl, PMID:20837040]
is_a: GO:0044627 ! modulation of complement activation, classical pathway in other organism
is_a: GO:0045959 ! negative regulation of complement activation, classical pathway
created_by: janelomax
creation_date: 2012-07-05T01:03:25Z

[Term]
id: GO:0044630
name: modulation of complement activation, lectin pathway in other organism
namespace: biological_process
def: "A process that modulates the frequency, rate or extent of the lectin pathway of complement activation, in a different organism." [GOC:jl, PMID:20837040]
synonym: "regulation of complement activation, lectin pathway in other organism" EXACT []
is_a: GO:0001868 ! regulation of complement activation, lectin pathway
is_a: GO:0044645 ! modulation of complement activation in other organism
created_by: janelomax
creation_date: 2012-07-05T01:10:31Z

[Term]
id: GO:0044631
name: positive regulation of complement activation, lectin pathway in other organism
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of complement activation by the lectin pathway, in a different organism." [GOC:jl, PMID:20837040]
is_a: GO:0001870 ! positive regulation of complement activation, lectin pathway
is_a: GO:0044630 ! modulation of complement activation, lectin pathway in other organism
created_by: janelomax
creation_date: 2012-07-05T01:17:33Z

[Term]
id: GO:0044632
name: negative regulation of complement activation, lectin pathway in other organism
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of complement activation by the lectin pathway, in a different organism." [GOC:jl, PMID:20837040]
is_a: GO:0001869 ! negative regulation of complement activation, lectin pathway
is_a: GO:0044630 ! modulation of complement activation, lectin pathway in other organism
created_by: janelomax
creation_date: 2012-07-05T01:18:43Z

[Term]
id: GO:0044633
name: modulation of complement activation, alternative pathway in other organism
namespace: biological_process
def: "A process that modulates the frequency, rate or extent of complement activation, via the alternative pathway, in a different organism." [GOC:jl, PMID:20837040]
synonym: "regulation of complement activation, alternative pathway in other organism" RELATED []
is_a: GO:0030451 ! regulation of complement activation, alternative pathway
is_a: GO:0044645 ! modulation of complement activation in other organism
created_by: janelomax
creation_date: 2012-07-05T04:24:08Z

[Term]
id: GO:0044634
name: negative regulation of complement activation, alternative pathway in other organism
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the alternative pathway, in a different organism." [GOC:jl, PMID:20837040]
is_a: GO:0044633 ! modulation of complement activation, alternative pathway in other organism
is_a: GO:0045957 ! negative regulation of complement activation, alternative pathway
created_by: janelomax
creation_date: 2012-07-05T04:32:55Z

[Term]
id: GO:0044635
name: positive regulation of complement activation, alternative pathway in other organism
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of complement activation by the alternative pathway, in a different organism." [GOC:jl, PMID:20837040]
is_a: GO:0044633 ! modulation of complement activation, alternative pathway in other organism
is_a: GO:0045958 ! positive regulation of complement activation, alternative pathway
created_by: janelomax
creation_date: 2012-07-05T04:36:11Z

[Term]
id: GO:0044636
name: envenomation resulting in modulation of complement activation, classical pathway in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the regulation of complement activation via the classical pathway of the bitten/stung organism." [GOC:fj, GOC:jl, PMID:20837040]
is_a: GO:0044646 ! envenomation resulting in modulation of complement activation in other organism
relationship: has_part GO:0044627 ! modulation of complement activation, classical pathway in other organism
created_by: janelomax
creation_date: 2012-07-05T04:40:57Z

[Term]
id: GO:0044637
name: envenomation resulting in negative regulation of complement activation, classical pathway in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the negative regulation of complement activation via the classical pathway of the bitten/stung organism." [GOC:fj, GOC:jl, PMID:20837040]
is_a: GO:0044636 ! envenomation resulting in modulation of complement activation, classical pathway in other organism
relationship: has_part GO:0044629 ! negative regulation of complement activation, classical pathway in other organism
created_by: janelomax
creation_date: 2012-07-05T04:46:56Z

[Term]
id: GO:0044638
name: envenomation resulting in positive regulation of complement activation, classical pathway in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the positive regulation of complement activation via the classical pathway of the bitten/stung organism." [GOC:fj, GOC:jl, PMID:20837040]
is_a: GO:0044636 ! envenomation resulting in modulation of complement activation, classical pathway in other organism
relationship: has_part GO:0044628 ! positive regulation of complement activation, classical pathway in other organism
created_by: janelomax
creation_date: 2012-07-05T04:51:36Z

[Term]
id: GO:0044639
name: envenomation resulting in modulation of complement activation, lectin pathway in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of complement activation via the lectin pathway in the bitten/stung organism." [GOC:fj, GOC:jl, PMID:20837040]
synonym: "envenomation resulting in regulation of complement activation, lectin pathway in other organism" EXACT []
is_a: GO:0044646 ! envenomation resulting in modulation of complement activation in other organism
relationship: has_part GO:0044630 ! modulation of complement activation, lectin pathway in other organism
created_by: janelomax
creation_date: 2012-07-05T04:53:36Z

[Term]
id: GO:0044640
name: envenomation resulting in negative regulation of complement activation, lectin pathway in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant negative regulation of complement activation via the lectin pathway in the bitten/stung organism." [GOC:fj, GOC:jl, PMID:20837040]
is_a: GO:0044639 ! envenomation resulting in modulation of complement activation, lectin pathway in other organism
relationship: has_part GO:0044632 ! negative regulation of complement activation, lectin pathway in other organism
created_by: janelomax
creation_date: 2012-07-05T04:56:30Z

[Term]
id: GO:0044641
name: envenomation resulting in positive regulation of complement activation, lectin pathway in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of complement activation via the lectin pathway in the bitten/stung organism." [GOC:fj, GOC:jl, PMID:20837040]
is_a: GO:0044639 ! envenomation resulting in modulation of complement activation, lectin pathway in other organism
relationship: has_part GO:0044631 ! positive regulation of complement activation, lectin pathway in other organism
created_by: janelomax
creation_date: 2012-07-11T11:50:23Z

[Term]
id: GO:0044642
name: envenomation resulting in modulation of complement activation, alternative pathway in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of complement activation via the alternative pathway in the bitten/stung organism." [GOC:fj, GOC:jl, PMID:20837040]
synonym: "envenomation resulting in regulation of complement activation, alternative pathway in other organism" EXACT []
is_a: GO:0044646 ! envenomation resulting in modulation of complement activation in other organism
relationship: has_part GO:0044633 ! modulation of complement activation, alternative pathway in other organism
created_by: janelomax
creation_date: 2012-07-11T11:53:12Z

[Term]
id: GO:0044643
name: envenomation resulting in positive regulation of complement activation, alternative pathway in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of complement activation via the alternative pathway in the bitten/stung organism." [GOC:fj, GOC:jl, PMID:20837040]
is_a: GO:0044642 ! envenomation resulting in modulation of complement activation, alternative pathway in other organism
relationship: has_part GO:0044635 ! positive regulation of complement activation, alternative pathway in other organism
created_by: janelomax
creation_date: 2012-07-11T11:56:48Z

[Term]
id: GO:0044644
name: envenomation resulting in negative regulation of complement activation, alternative pathway in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant negative regulation of complement activation via the alternative pathway in the bitten/stung organism." [GOC:fj, GOC:jl, PMID:20837040]
is_a: GO:0044642 ! envenomation resulting in modulation of complement activation, alternative pathway in other organism
relationship: has_part GO:0044634 ! negative regulation of complement activation, alternative pathway in other organism
created_by: janelomax
creation_date: 2012-07-11T12:35:11Z

[Term]
id: GO:0044645
name: modulation of complement activation in other organism
namespace: biological_process
def: "A process that modulates the frequency, rate or extent of complement activation in a different organism." [GOC:fj, GOC:jl, PMID:20837040]
synonym: "regulation of complement activation in other organism" EXACT []
is_a: GO:0035821 ! modification of morphology or physiology of other organism
is_a: GO:0045088 ! regulation of innate immune response
created_by: janelomax
creation_date: 2012-07-11T12:37:50Z

[Term]
id: GO:0044646
name: envenomation resulting in modulation of complement activation in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of complement activation in the bitten/stung organism." [GOC:fj, GOC:jl, PMID:20837040]
synonym: "envenomation resulting in regulation of complement activation in other organism" EXACT []
is_a: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism
relationship: has_part GO:0044645 ! modulation of complement activation in other organism
created_by: janelomax
creation_date: 2012-07-11T12:49:28Z

[Term]
id: GO:0044647
name: host-symbiont bicellular tight junction
namespace: cellular_component
def: "An occluding cell-cell junction formed between the membranes of the apical end of an invading cell (e.g. a merozoite in Plasmodium) and a host target cell (e.g. erythrocyte for Plasmodium infection). The junction is a stable yet dynamic structure that moves around the symbiont cell during invasion, enclosing it in a vacuole surrounded by a membrane." [GOC:jl, PMID:21803641]
synonym: "host-parasite tight junction" EXACT []
synonym: "host-pathogen tight junction" EXACT []
is_a: GO:0005923 ! bicellular tight junction
created_by: janelomax
creation_date: 2012-07-11T12:56:18Z

[Term]
id: GO:0044648
name: histone H3-K4 dimethylation
namespace: biological_process
def: "The modification of histone H3 by addition of two methyl groups to lysine at position 4 of the histone." [GOC:jl, PMID:21875999]
is_a: GO:0018027 ! peptidyl-lysine dimethylation
is_a: GO:0051568 ! histone H3-K4 methylation
created_by: janelomax
creation_date: 2012-07-11T01:27:33Z

[Term]
id: GO:0044649
name: envenomation resulting in cytolysis in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with cytolysis in the bitten organism." [GOC:fj, GOC:jl, PMID:22484288]
is_a: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism
intersection_of: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism
intersection_of: has_part GO:0051715 ! cytolysis in other organism
relationship: has_part GO:0051715 ! cytolysis in other organism
created_by: janelomax
creation_date: 2012-07-11T02:13:38Z

[Term]
id: GO:0044650
name: adhesion of symbiont to host cell
namespace: biological_process
def: "The attachment of a symbiont to a host cell via adhesion molecules, general stickiness etc., either directly or indirectly." [GOC:jl]
is_a: GO:0044406 ! adhesion of symbiont to host
created_by: janelomax
creation_date: 2012-07-12T12:42:14Z

[Term]
id: GO:0044651
name: adhesion of symbiont to host epithelial cell
namespace: biological_process
def: "The attachment of a symbiont to a host epithelial cell via adhesion molecules, general stickiness etc., either directly or indirectly." [GOC:jl, PMID:10066176]
is_a: GO:0044650 ! adhesion of symbiont to host cell
created_by: janelomax
creation_date: 2012-07-12T12:47:09Z

[Term]
id: GO:0044652
name: adhesion of symbiont to host endothelial cell
namespace: biological_process
def: "The attachment of a symbiont to a host endothelial cell via adhesion molecules, general stickiness etc., either directly or indirectly." [GOC:jl, PMID:10066176]
is_a: GO:0044650 ! adhesion of symbiont to host cell
created_by: janelomax
creation_date: 2012-07-12T12:49:07Z

[Term]
id: GO:0044653
name: dextrin alpha-glucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: dextrin + H2O = alpha-D-glucose." [PMID:18556189]
xref: EC:3.2.1.-
is_a: GO:0090599 ! alpha-glucosidase activity
created_by: janelomax
creation_date: 2012-07-23T02:01:12Z

[Term]
id: GO:0044654
name: starch alpha-glucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: starch + H2O = alpha-D-glucose." [PMID:18556189]
xref: EC:3.2.1.-
is_a: GO:0090599 ! alpha-glucosidase activity
created_by: janelomax
creation_date: 2012-07-23T02:08:10Z

[Term]
id: GO:0044655
name: phagosome reneutralization
namespace: biological_process
def: "Any process that increases the pH of the phagosome, measured by the concentration of the hydrogen ion, as part of the process of phagosome maturation." [GOC:rjd, PMID:22008230]
synonym: "phagosomal reneutralization" EXACT []
synonym: "phagosome pH elevation" EXACT []
is_a: GO:0051454 ! intracellular pH elevation
relationship: part_of GO:0090382 ! phagosome maturation
created_by: janelomax
creation_date: 2012-07-26T04:21:14Z

[Term]
id: GO:0044656
name: regulation of post-lysosomal vacuole size
namespace: biological_process
def: "Any process that modulates the volume of a post-lysosomal vacuole, a membrane-bounded intracellular vesicle formed late in the endocytic pathway when the pH in the vacuole becomes neutral prior to exocytosis." [GOC:rjd, PMID:22008230]
is_a: GO:0032535 ! regulation of cellular component size
created_by: janelomax
creation_date: 2012-07-26T04:30:56Z

[Term]
id: GO:0044657
name: pore formation in membrane of other organism during symbiotic interaction
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components by an organism to form a pore complex in a membrane of another organism, occurring as part of a symbiotic interaction." [GOC:jl]
is_a: GO:0035915 ! pore formation in membrane of other organism
is_a: GO:0052025 ! modification by symbiont of host cell membrane
created_by: janelomax
creation_date: 2012-08-01T13:12:10Z

[Term]
id: GO:0044658
name: pore formation in membrane of host by symbiont
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components by an organism to form a pore complex in a membrane of a host organism." [GOC:jl]
is_a: GO:0044657 ! pore formation in membrane of other organism during symbiotic interaction
created_by: janelomax
creation_date: 2012-08-01T13:14:42Z

[Term]
id: GO:0044659
name: cytolysis by virus of host cell
namespace: biological_process
alt_id: GO:0019077
alt_id: GO:0046756
def: "The killing by a virus of a cell in its host organism by means of the rupture of cell membranes and the loss of cytoplasm." [GOC:jl]
subset: gosubset_prok
synonym: "lytic viral life cycle" RELATED []
synonym: "lytic viral release" EXACT []
synonym: "viral release by cell lysis" EXACT []
synonym: "viral release by host cell lysis" EXACT []
xref: VZ:1077 "Cell lysis"
is_a: GO:0001897 ! cytolysis by symbiont of host cells
is_a: GO:0019076 ! viral release from host cell
is_a: GO:0039633 ! killing by virus of host cell
is_a: GO:0044661 ! disruption by virus of host cell
created_by: janelomax
creation_date: 2012-08-01T13:16:39Z

[Term]
id: GO:0044660
name: cytolysis by virus via pore formation in host cell membrane
namespace: biological_process
def: "The killing by a virus of a cell in its host organism by cytolysis, caused by the formation by the virus of pores in its host cell membrane." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044659 ! cytolysis by virus of host cell
relationship: has_part GO:0044658 ! pore formation in membrane of host by symbiont
created_by: janelomax
creation_date: 2012-08-01T13:23:41Z

[Term]
id: GO:0044661
name: disruption by virus of host cell
namespace: biological_process
def: "A process by which a virus has a negative effect on the functioning of the host's cell." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044004 ! disruption by symbiont of host cell
created_by: janelomax
creation_date: 2012-08-01T13:41:00Z

[Term]
id: GO:0044662
name: disruption by virus of host cell membrane
namespace: biological_process
def: "A process by which a virus has a negative effect on the functioning of a host cellular membrane." [GOC:jl]
subset: gosubset_prok
synonym: "disruption by organism of host cell membrane" EXACT []
synonym: "disruption by virus of host cell membrane" NARROW [GOC:bf, GOC:jl]
is_a: GO:0044661 ! disruption by virus of host cell
is_a: GO:0051673 ! membrane disruption in other organism
is_a: GO:0052025 ! modification by symbiont of host cell membrane
created_by: janelomax
creation_date: 2012-08-01T13:44:52Z

[Term]
id: GO:0044663
name: establishment or maintenance of cell type involved in phenotypic switching
namespace: biological_process
def: "A cellular process of the specification, formation or maintenance of an alternative cell type, occurring as part of the process of phenotypic switching. Phenotypic switching begins with changes in cell morphology and altered gene expression patterns and ends when the morphology of a population of cells has reverted back to the default state, accompanied by altered expression patterns." [GOC:jl]
is_a: GO:0044763 ! single-organism cellular process
relationship: part_of GO:0036166 ! phenotypic switching
created_by: janelomax
creation_date: 2012-08-07T14:30:07Z

[Term]
id: GO:0044664
name: reversion of cell type to default state involved in phenotypic switching
namespace: biological_process
def: "The cellular process of the reversion of cells to their original cell type, occurring as part of the process of phenotypic switching. Phenotypic switching begins with changes in cell morphology and altered gene expression patterns and ends when the morphology of a population of cells has reverted back to the default state, accompanied by altered expression patterns." [GOC:jl]
is_a: GO:0044763 ! single-organism cellular process
relationship: part_of GO:0036166 ! phenotypic switching
created_by: janelomax
creation_date: 2012-08-07T14:35:48Z

[Term]
id: GO:0044665
name: MLL1/2 complex
namespace: cellular_component
def: "A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL1 or MLL2 in human, or equivalent in other species." [GOC:sart, PMID:21875999]
synonym: "Trx-containing complex" EXACT []
is_a: GO:0035097 ! histone methyltransferase complex
created_by: janelomax
creation_date: 2012-08-07T14:44:12Z

[Term]
id: GO:0044666
name: MLL3/4 complex
namespace: cellular_component
def: "A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL3 or MLL4 in mammals, or equivalent in other species." [GOC:sart, PMID:21875999]
synonym: "Trr/COMPASS-like complex" EXACT []
is_a: GO:0035097 ! histone methyltransferase complex
created_by: janelomax
creation_date: 2012-08-07T14:46:40Z

[Term]
id: GO:0044667
name: (R)-carnitine:4-(trimethylammonio)butanoate antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (R)-carnitine(out) + 4-(trimethylammonio)butanoate(in) = (R)-carnitine(in) + 4-(trimethylammonio)butanoate(out)." [GOC:crds]
synonym: "(R)-carnitine:gamma-butyrobetaine antiporter activity" EXACT []
synonym: "L-carnitine:4-(trimethylammonio)butanoate antiporter activity" EXACT []
synonym: "L-carnitine:gamma-butyrobetaine antiporter activity" EXACT []
xref: RHEA:29430
is_a: GO:0015491 ! cation:cation antiporter activity
is_a: GO:1901235 ! (R)-carnitine transmembrane transporter activity
is_a: GO:1901236 ! 4-(trimethylammonio)butanoate transmembrane transporter activity
created_by: janelomax
creation_date: 2012-08-08T11:17:12Z

[Term]
id: GO:0044668
name: sodium:malonate symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sodium(out)+ malonate(out) = sodium(in) + malonate(in)." [GOC:crds]
xref: RHEA:33138
is_a: GO:0015294 ! solute:cation symporter activity
created_by: janelomax
creation_date: 2012-08-08T11:59:48Z

[Term]
id: GO:0044669
name: sodium:galactoside symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sodium(out)+ galactoside(out) = sodium(in) + galactoside(in)." [GOC:crds]
is_a: GO:0015294 ! solute:cation symporter activity
created_by: janelomax
creation_date: 2012-08-08T12:55:32Z

[Term]
id: GO:0044670
name: sodium:alanine symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sodium(out)+ alanine(out) = sodium(in) + alanine(in)." [GOC:crds]
xref: RHEA:29286
is_a: GO:0015294 ! solute:cation symporter activity
created_by: janelomax
creation_date: 2012-08-08T12:57:30Z

[Term]
id: GO:0044671
name: sorocarp spore cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a sorocarp spore cell, a cell of the sorocarp sorus. A sorocarp is the fruiting body characteristic of certain cellular slime moulds (e.g., Dictyosteliida) and consists of both stalk and a sorus (spore mass)." [GOC:jl, GOC:rjd]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0030154 ! cell differentiation
is_a: GO:0044702 ! single organism reproductive process
relationship: part_of GO:0048837 ! sorus development
created_by: janelomax
creation_date: 2012-08-08T13:10:48Z

[Term]
id: GO:0044672
name: acetyl-CoA decarbonylase/synthase-carbon monoxide dehydrogenase complex
namespace: cellular_component
def: "A multifunctional enzyme complex composed of five different polypeptides that catalyzes the decarbonylation of acetyl-CoA, cleaves the C-C and C-S bonds in the acetyl moiety of acetyl-CoA, oxidizes the carbonyl group to CO2 and transfers the methyl group to tetrahydrosarcinapterin. These reactions are important for methanogenesis." [GOC:mengo_curators, PMID:11607176, PMID:7693685, PMID:8955306]
synonym: "carbon monoxide dehydrogenase" BROAD []
synonym: "carbon-monoxide:(acceptor) oxidoreductase complex" BROAD []
synonym: "CO dehydrogenase complex" BROAD []
synonym: "CO dehydrogenase/acetyl-CoA synthase complex" EXACT []
synonym: "CODH" BROAD []
synonym: "CODH/ACS complex" EXACT []
is_a: GO:0043234 ! protein complex
created_by: janelomax
creation_date: 2012-08-08T16:06:03Z

[Term]
id: GO:0044673
name: 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase complex
namespace: cellular_component
def: "A heterodimer which catalyses the reaction of 5-amino-6-(D-ribitylamino)uracil and 4-hydroxyphenylpyruvate to form 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO), an intermediate of coenzyme F420." [GOC:mengo_curators, PMID:14593448]
synonym: "FO-synthase complex" EXACT []
is_a: GO:1990234 ! transferase complex
created_by: janelomax
creation_date: 2012-08-09T10:49:05Z

[Term]
id: GO:0044674
name: methyl coenzyme M reductase complex
namespace: cellular_component
def: "A hexameric complex consisting of three polypeptides in an alpha2beta2gamma2 arrangement. Involved in the reduction of the coenzyme M-bound methyl group to methane, which is the final step in methanogenesis." [GOC:mengo_curators, PMID:9367957]
is_a: GO:1990234 ! transferase complex
created_by: janelomax
creation_date: 2012-08-09T10:52:33Z

[Term]
id: GO:0044675
name: formyl-methanofuran dehydrogenase (tungsten enzyme) complex
namespace: cellular_component
def: "A protein complex consisting of four polypeptides which also contains tungsten, a molybdopterin guanine dinucleotide, and iron-sulfur clusters. This protein complex catalyzes the reversible conversion of CO2 and methanofuran to formylmethanofuran during methanogenesis." [GOC:mengo_curators, PMID:8125106, PMID:8575452]
is_a: GO:0043234 ! protein complex
created_by: janelomax
creation_date: 2012-08-09T10:54:49Z

[Term]
id: GO:0044676
name: formyl-methanofuran dehydrogenase (molybdenum enzyme) complex
namespace: cellular_component
def: "A protein complex consisting of three polypeptides which also contains molybdenum, a molybdopterin guanine dinucleotide and iron-sulfur clusters. This protein complex catalyzes the reversible conversion of CO2 and methanofuran to formylmethanofuran during methanogenesis." [GOC:mengo_curators, PMID:1915887, PMID:8954165]
is_a: GO:0043234 ! protein complex
created_by: janelomax
creation_date: 2012-08-09T10:56:51Z

[Term]
id: GO:0044677
name: methyl-tetrahydromethanopterin:coenzyme M methyltransferase complex
namespace: cellular_component
def: "A protein complex consisted of eight polypeptides. This complex catalyzes the formation of methyl-coenzyme M and H4MPT from N5-methyl-H4MPT and CoM during methanogenesis." [GOC:mengo_curators, PMID:8477726]
synonym: "5-methyl-5,6,7,8-tetrahydromethanopterin:2-mercaptoethane sulfonate 2-methyltransferase complex" EXACT []
synonym: "coenzyme M methyltransferase complex" BROAD []
synonym: "methyl-H4MPT" BROAD []
synonym: "N5-methyltetrahydromethanopterin-coenzyme M methyltransferase complex" EXACT []
is_a: GO:0043234 ! protein complex
created_by: janelomax
creation_date: 2012-08-09T10:58:24Z

[Term]
id: GO:0044678
name: CoB-CoM heterodisulfide reductase complex
namespace: cellular_component
def: "A protein complex that in Methanobacterium thermoautotrophicum is composed of six subunits, and in Methanosarcina barkeri contains is composed of either two subunits or nine subunits. Catalyzes the conversion of coenzyme B, coenzyme M, and methanophenazine to form N-{7-[(2-sulfoethyl)dithio]heptanoyl}-3-O-phospho-L-threonine and dihydromethanophenazine." [GOC:mengo_curators, PMID:8119281, PMID:8174566, PMID:9063468]
synonym: "coenzyme M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide hydrogenase complex" EXACT []
synonym: "hydrogen:coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide oxidoreductase complex" EXACT []
is_a: GO:1990204 ! oxidoreductase complex
created_by: janelomax
creation_date: 2012-08-09T11:01:43Z

[Term]
id: GO:0044679
name: methanophenazine reducing hydrogenase complex
namespace: cellular_component
def: "A protein complex which catalyzes the conversion of methanophenazine and hydrogen to form dihydromethanophenazine. This typically consists of three polypeptides" [GOC:mengo_curators, PMID:9555882]
is_a: GO:1990204 ! oxidoreductase complex
created_by: janelomax
creation_date: 2012-08-09T11:07:20Z

[Term]
id: GO:0044680
name: methylthiol:coenzyme M methyltransferase complex
namespace: cellular_component
def: "A protein complex of two polypeptides which catalyzes the transfer of methyl group from methylthiol to coenzyme M during methanogenesis." [GOC:mengo_curators, PMID:11073950, PMID:9371433]
synonym: "methylthiol coenzyme M methyl transferase complex" EXACT []
synonym: "methylthiol:coenzyme M methyl transferase complex" EXACT []
synonym: "methylthiol:CoM methyltransferase complex" EXACT []
is_a: GO:0034708 ! methyltransferase complex
created_by: janelomax
creation_date: 2012-08-09T11:08:22Z

[Term]
id: GO:0044681
name: sulfopyruvate decarboxylase complex
namespace: cellular_component
def: "A complex of two polypeptides which form a dodecamer (A6B6). Catalyzes the decarboxylation of sulfopyruvic acid to sulfoacetaldehyde. This reaction is involved in coenzyme M biosynthesis." [GOC:mengo_curators, PMID:10940029]
is_a: GO:1902494 ! catalytic complex
created_by: janelomax
creation_date: 2012-08-09T11:12:47Z

[Term]
id: GO:0044682
name: archaeal-specific GTP cyclohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP + H2O <=> 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate + diphosphate +formate + H+. This activity is part of the biosynthesis of methanopterin in Archaea, and requires Fe2+." [GOC:mengo_curators, PMID:17497938]
subset: gosubset_prok
synonym: "Fe(2+)-dependent archaeal-specific GTP cyclohydrolase activity" EXACT []
synonym: "MptA activity" NARROW []
xref: EC:3.5.4.-
is_a: GO:0003933 ! GTP cyclohydrolase activity
created_by: janelomax
creation_date: 2012-08-15T11:18:40Z

[Term]
id: GO:0044683
name: methylthiol:coenzyme M methyltransferase activity
namespace: molecular_function
def: "Catalysis of the overall reaction: methyl-Co(III) methylated-thiol-specific corrinoid protein + coenzyme M = Co(I) methylated--thiol-specific corrinoid protein + methyl-CoM." [MetaCyc:RXN-8125, PMID:9371433]
comment: This reaction is achieved by the catalysis of two successive steps carried out by the same enzyme - the transfer of a methyl group from the substrate to the cobalt cofactor of a methylated-thiol-specific corrinoid protein (MtsB), and the subsequent transfer of the methyl group from the corrinoid protein to coenzyme M. With most other methanogenesis substrates this process is carried out by two different enzymes (for example, EC 2.1.1.90, methanol-corrinoid protein Co-methyltransferase, and EC 2.1.1.246, methylated methanol-specific corrinoid protein:coenzyme M methyltransferase). The cobalt is oxidized during methylation from the Co(I) state to the Co(III) state, and is reduced back to the Co(I) form during demethylation.
synonym: "methylthiol:coenzyme M methyl transferase activity" EXACT []
xref: EC:2.1.1.251
xref: MetaCyc:RXN-8125
xref: RHEA:32670
is_a: GO:0008168 ! methyltransferase activity
created_by: janelomax
creation_date: 2012-08-15T11:41:24Z

[Term]
id: GO:0044684
name: dihydromethanopterin reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7,8-dihydromethanopterin + NADPH = 5,6,7,8-tetrahydromethanopterin + NADP." [GOC:mengo_curators, PMID:15028691]
xref: EC:1.5.1.-
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
relationship: part_of GO:2001118 ! tetrahydromethanopterin biosynthetic process
created_by: janelomax
creation_date: 2012-08-15T13:57:55Z

[Term]
id: GO:0044685
name: tetrahydromethanopterin-dependent serine hydroxymethyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: tetrahydromethanopterin + L-serine = 5,10-methylenetetrahydromethanopterin + glycine + H2O." [GOC:mengo_curators, PMID:12902326]
xref: EC:2.1.2.-
is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity
created_by: janelomax
creation_date: 2012-08-15T14:13:07Z

[Term]
id: GO:0044686
name: cysteate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-phosphoserine + SO32- = L-cysteate + HPO4-." [GOC:mengo_curators, PMID:19761441]
xref: EC:2.5.1.76
xref: MetaCyc:RXN-11108
xref: RHEA:26489
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups
created_by: janelomax
creation_date: 2012-08-15T14:16:05Z

[Term]
id: GO:0044687
name: geranylfarnesyl diphosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranylgeranyl diphosphate + isopentenyl diphosphate = (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate." [GOC:mengo_curators, PMID:20097171]
xref: EC:2.5.1.81
xref: MetaCyc:RXN-8813
xref: RHEA:25697
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups
created_by: janelomax
creation_date: 2012-08-15T14:20:25Z

[Term]
id: GO:0044688
name: 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate + H2O = 7,8-dihydroneopterin 3'-phosphate + H+." [GOC:mengo_curators, PMID:19746965]
xref: EC:3.1.4.-
is_a: GO:0008081 ! phosphoric diester hydrolase activity
relationship: part_of GO:2001116 ! methanopterin-containing compound biosynthetic process
created_by: janelomax
creation_date: 2012-08-15T14:28:30Z

[Term]
id: GO:0044689
name: 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-amino-6-(D-ribitylamino)uracil + 4-hydroxyphenylpyruvate + 2 S-adenosyl-L-methionine + H2O = 7,8-didemethyl-8-hydroxy-5-deazariboflavin + 2 5'-deoxyadenosine + 2 L-methionine + oxalate + ammonia + 4 H+." [GOC:mengo_curators, PMID:11948155, PMID:14593448]
synonym: "FO synthase" EXACT []
xref: EC:2.5.1.77
xref: MetaCyc:RXN-8079
xref: RHEA:27376
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups
created_by: janelomax
creation_date: 2012-08-15T14:33:17Z

[Term]
id: GO:0044690
name: methionine import
namespace: biological_process
def: "The directed movement of methionine into a cell or organelle." [GOC:mah]
is_a: GO:0015821 ! methionine transport
is_a: GO:0043090 ! amino acid import
created_by: janelomax
creation_date: 2012-08-15T14:54:38Z

[Term]
id: GO:0044691
name: tooth eruption
namespace: biological_process
def: "The tooth development process in which the teeth enter the mouth and become visible." [Wikipedia:Tooth_eruption]
xref: Wikipedia:Tooth_eruption
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0042476 ! odontogenesis
created_by: janelomax
creation_date: 2012-08-15T14:58:17Z

[Term]
id: GO:0044692
name: exoribonuclease activator activity
namespace: molecular_function
def: "Binds to and increases the activity of an exoribonuclease." [GOC:rb, PMID:22570495]
is_a: GO:0008047 ! enzyme activator activity
relationship: part_of GO:0032075 ! positive regulation of nuclease activity
created_by: janelomax
creation_date: 2012-08-15T15:13:57Z

[Term]
id: GO:0044693
name: trehalose:proton symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: trehalose(out) + H+(out) = trehalose(in) + H+(in)." [PMID:11136464]
synonym: "trehalose:hydrogen symporter activity" EXACT []
is_a: GO:0005351 ! sugar:proton symporter activity
is_a: GO:0015574 ! trehalose transmembrane transporter activity
created_by: janelomax
creation_date: 2012-08-15T15:19:27Z

[Term]
id: GO:0044694
name: pore-mediated entry of viral genome into host cell
namespace: biological_process
def: "Injection by a non-enveloped virus of the viral genome into the host cytoplasm through creation of a pore or channel in the host cell membrane(s). Usually mediated by a viral pore-forming peptide associated with the viral capsid or bacteriophage tail." [GOC:jl, UniProtKB-KW:KW-1172, VZ:979]
comment: This mechanism is used by animal viruses such as poliovirus. Various tailed bacteriophages also carry specialized proteins which open a pore or a channel in the host membrane(s) to allow genome delivery into host cytoplasm.
synonym: "membrane puncture-mediated penetration of viral genome into host cell" RELATED [UniProtKB-KW:KW-1172]
synonym: "pore-mediated penetration of viral genome into host cell" EXACT []
synonym: "viral entry via genome injection" EXACT []
synonym: "viral genome delivery via icosahedral vertex" NARROW []
synonym: "viral genome translocation" EXACT []
synonym: "viral pore-forming protein" RELATED [GOC:bf]
xref: VZ:979 "Pore-mediated penetration of viral genome into host cell"
is_a: GO:0046718 ! viral entry into host cell
is_a: GO:0046794 ! transport of virus
relationship: has_part GO:0039707 ! pore formation by virus in membrane of host cell
created_by: janelomax
creation_date: 2012-08-16T11:08:02Z

[Term]
id: GO:0044695
name: Dsc E3 ubiquitin ligase complex
namespace: cellular_component
def: "An E3 ubiquitin ligase complex localized to the ER and Golgi membrane. In fission yeast comprises Dsc1, 2, 3 and 4. Involved in the processes of fission yeast sre1 (human SREBP) transcriptional activator proteolytic cleavage, the multivesicular body (MVB) pathway, and a post-endoplasmic reticulum pathway for protein catabolism." [GOC:mah, GOC:vw, PMID:21504829]
is_a: GO:0000151 ! ubiquitin ligase complex
is_a: GO:0044422 ! organelle part
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0031090 ! organelle membrane
created_by: janelomax
creation_date: 2012-08-16T13:41:48Z

[Term]
id: GO:0044696
name: killing by virus of host cell by post-segregational killing
namespace: biological_process
def: "The process by which a virus causes the death of daughter cells which do not contain its genes after host cell division, by a mechanism of post-segregational killing (PSK). The extrachromosomal viral DNA consist of two genes; the product of the second is long lived and toxic, while the product of the first is short lived and antagonizes the lethal action of the toxin. Daughter cells that do not contain the viral extrachromosomal element are killed by the long lived toxin, while daughter cells that do contain the viral extrachromosomal element are protected by the action of the short lived antitoxin it encodes." [GOC:bf, GOC:jl, PMID:11222604, Wikipedia:Toxin-antitoxin_system]
comment: Note that this process occurs after the cell division partitioning event.
synonym: "killing by virus of host cell by PSK" EXACT []
synonym: "killing by virus of host cell by toxin-antitoxin system" EXACT []
is_a: GO:0039633 ! killing by virus of host cell
created_by: janelomax
creation_date: 2012-08-16T13:58:18Z

[Term]
id: GO:0044697
name: HICS complex
namespace: cellular_component
def: "A multisubunit complex involved in cytokinesis. In the yeast Saccharomyces cerevisiae this complex consists of Sho1p, Hof1p, Inn1p and Cyk3p proteins." [PMID:22623719]
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
created_by: janelomax
creation_date: 2012-09-19T13:30:22Z

[Term]
id: GO:0044698
name: morphogenesis of symbiont in host cell
namespace: biological_process
def: "The process in which a symbiont undergoes a change in shape or form, within the host's cell." [GOC:jl]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044111 ! development involved in symbiotic interaction
relationship: part_of GO:0044118 ! development of symbiont in host cell
created_by: janelomax
creation_date: 2012-09-19T14:10:53Z

[Term]
id: GO:0044699
name: single-organism process
namespace: biological_process
def: "A biological process that involves only one organism." [GOC:jl]
synonym: "single organism process" EXACT []
is_a: GO:0008150 ! biological_process
disjoint_from: GO:0044848 ! biological phase
created_by: janelomax
creation_date: 2012-09-19T15:05:24Z

[Term]
id: GO:0044700
name: single organism signaling
namespace: biological_process
def: "A signaling process occurring within a single organism." [GOC:jl]
is_a: GO:0023052 ! signaling
is_a: GO:0044699 ! single-organism process
created_by: janelomax
creation_date: 2012-09-19T15:12:49Z

[Term]
id: GO:0044701
name: obsolete response to stimulus by single organism
namespace: biological_process
def: "OBSOLETE. A response to a stimulus that involves only one organism." [GOC:jl]
comment: This term was made obsolete because we decided that all responses are single-organism.
synonym: "response to stimulus by single organism" EXACT []
is_obsolete: true
created_by: janelomax
creation_date: 2012-09-19T15:40:57Z

[Term]
id: GO:0044702
name: single organism reproductive process
namespace: biological_process
def: "A biological process that directly contributes to the process of producing new individuals, involving a single organism." [GOC:jl]
is_a: GO:0022414 ! reproductive process
is_a: GO:0044699 ! single-organism process
created_by: janelomax
creation_date: 2012-09-19T15:56:06Z

[Term]
id: GO:0044703
name: multi-organism reproductive process
namespace: biological_process
def: "A biological process that directly contributes to the process of producing new individuals, involving another organism." [GOC:jl]
is_a: GO:0022414 ! reproductive process
is_a: GO:0051704 ! multi-organism process
created_by: janelomax
creation_date: 2012-09-19T15:56:30Z

[Term]
id: GO:0044704
name: single-organism reproductive behavior
namespace: biological_process
def: "The specific behavior of an organism that is associated with reproduction involving a single organism." [GOC:jl, GOC:pr]
is_a: GO:0019098 ! reproductive behavior
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0044708 ! single-organism behavior
created_by: janelomax
creation_date: 2012-09-19T16:01:37Z

[Term]
id: GO:0044705
name: multi-organism reproductive behavior
namespace: biological_process
def: "The specific behavior of an organism that is associated with reproduction involving another organism of the same or different species." [GOC:jl, GOC:pr]
is_a: GO:0019098 ! reproductive behavior
is_a: GO:0044703 ! multi-organism reproductive process
is_a: GO:0051705 ! multi-organism behavior
created_by: janelomax
creation_date: 2012-09-19T16:02:12Z

[Term]
id: GO:0044706
name: multi-multicellular organism process
namespace: biological_process
def: "A multicellular organism process which involves another multicellular organism of the same or different species." [GOC:jl]
is_a: GO:0032501 ! multicellular organismal process
is_a: GO:0051704 ! multi-organism process
created_by: janelomax
creation_date: 2012-09-19T16:06:16Z

[Term]
id: GO:0044707
name: single-multicellular organism process
namespace: biological_process
def: "A biological process occurring within a single, multicellular organism." [GOC:jl]
is_a: GO:0032501 ! multicellular organismal process
is_a: GO:0044699 ! single-organism process
created_by: janelomax
creation_date: 2012-09-19T16:07:47Z

[Term]
id: GO:0044708
name: single-organism behavior
namespace: biological_process
def: "The specific behavior of a single organism in response to external or internal stimuli." [GOC:jl, GOC:pr]
is_a: GO:0007610 ! behavior
is_a: GO:0044699 ! single-organism process
created_by: janelomax
creation_date: 2012-09-20T14:06:08Z

[Term]
id: GO:0044710
name: single-organism metabolic process
namespace: biological_process
def: "A metabolic process - chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances - which involves a single organism." [GOC:jl]
is_a: GO:0008152 ! metabolic process
is_a: GO:0044699 ! single-organism process
created_by: janelomax
creation_date: 2012-10-17T15:46:40Z

[Term]
id: GO:0044711
name: single-organism biosynthetic process
namespace: biological_process
def: "A biosynthetic process - chemical reactions and pathways resulting in the formation of substances - involving a single organism." [GOC:jl]
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0044710 ! single-organism metabolic process
created_by: janelomax
creation_date: 2012-10-17T15:52:18Z

[Term]
id: GO:0044712
name: single-organism catabolic process
namespace: biological_process
def: "A catabolic process - chemical reactions and pathways resulting in the breakdown of substances - which involves a single organism." [GOC:jl]
is_a: GO:0009056 ! catabolic process
is_a: GO:0044710 ! single-organism metabolic process
created_by: janelomax
creation_date: 2012-10-17T15:52:35Z

[Term]
id: GO:0044713
name: 2-hydroxy-adenosine triphosphate pyrophosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxy-adenosine-triphosphate + H2O = 2-hydroxy-adenosine phosphate + diphosphate." [GOC:pde, PMID:11139615]
synonym: "2-hydroxy-ATP pyrophosphatase activity" EXACT []
is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity
created_by: janelomax
creation_date: 2012-10-18T13:22:38Z

[Term]
id: GO:0044714
name: 2-hydroxy-(deoxy)adenosine-triphosphate pyrophosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxy-(deoxy)adenosine-triphosphate + H2O = 2-hydroxy-(deoxy)adenosine phosphate + diphosphate." [GOC:pde, PMID:11139615]
synonym: "2-hydroxy-(d)ATP pyrophosphatase activity" EXACT []
is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity
created_by: janelomax
creation_date: 2012-10-18T13:24:32Z

[Term]
id: GO:0044715
name: 8-oxo-dGDP phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction 8-oxo-dGDP + H2O = 8-oxo-dGMP + phosphate." [GOC:pde, PMID:22556419]
is_a: GO:0017110 ! nucleoside-diphosphatase activity
created_by: janelomax
creation_date: 2012-10-18T13:31:09Z

[Term]
id: GO:0044716
name: 8-oxo-GDP phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction 8-oxo-GDP + H2O = 8-oxo-GMP + phosphate." [GOC:pde, PMID:22556419]
is_a: GO:0017110 ! nucleoside-diphosphatase activity
created_by: janelomax
creation_date: 2012-10-18T13:32:39Z

[Term]
id: GO:0044717
name: 8-hydroxy-dADP phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction8-hydroxy-dADP + H2O = 8-hydroxy-dAMP + phosphate." [GOC:pde, PMID:22556419]
is_a: GO:0017110 ! nucleoside-diphosphatase activity
created_by: janelomax
creation_date: 2012-10-18T13:33:32Z

[Term]
id: GO:0044718
name: siderophore transmembrane transport
namespace: biological_process
def: "The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, from one side of a membrane to the other, by means of some agent such as a transporter or pore." [GOC:jl]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "siderophore membrane transport" EXACT []
is_a: GO:0015891 ! siderophore transport
is_a: GO:0055085 ! transmembrane transport
created_by: janelomax
creation_date: 2012-10-18T13:43:56Z

[Term]
id: GO:0044719
name: regulation of imaginal disc-derived wing size
namespace: biological_process
def: "Any process that modulates the size of an imaginal disc-derived wing." [PMID:21393605]
is_a: GO:0090066 ! regulation of anatomical structure size
relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis
created_by: janelomax
creation_date: 2012-10-18T13:49:12Z

[Term]
id: GO:0044720
name: negative regulation of imaginal disc-derived wing size
namespace: biological_process
def: "Any process that reduces the size of an imaginal disc-derived wing." [PMID:21393605]
is_a: GO:0044719 ! regulation of imaginal disc-derived wing size
created_by: janelomax
creation_date: 2012-10-18T13:50:49Z

[Term]
id: GO:0044721
name: protein import into peroxisome matrix, substrate release
namespace: biological_process
def: "The process by which the cargo protein is released into the peroxisomal matrix, following translocation across the membrane." [PMID:21976670]
is_a: GO:0043624 ! cellular protein complex disassembly
relationship: part_of GO:0016558 ! protein import into peroxisome matrix
created_by: janelomax
creation_date: 2012-10-18T14:07:40Z

[Term]
id: GO:0044722
name: renal phosphate excretion
namespace: biological_process
def: "The elimination by an organism of phosphate ions in the urine." [GOC:jl, PMID:21451460]
synonym: "renal phosphate ion excretion" EXACT []
is_a: GO:0003014 ! renal system process
is_a: GO:0007588 ! excretion
created_by: janelomax
creation_date: 2012-10-18T14:54:00Z

[Term]
id: GO:0044723
name: single-organism carbohydrate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving carbohydrates, occurring within a single organism." [GOC:jl]
is_a: GO:0005975 ! carbohydrate metabolic process
is_a: GO:0044710 ! single-organism metabolic process
created_by: janelomax
creation_date: 2012-10-23T15:40:34Z

[Term]
id: GO:0044724
name: single-organism carbohydrate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of carbohydrates, occurring within a single organism." [GOC:jl]
is_a: GO:0016052 ! carbohydrate catabolic process
is_a: GO:0044712 ! single-organism catabolic process
is_a: GO:0044723 ! single-organism carbohydrate metabolic process
created_by: janelomax
creation_date: 2012-10-23T16:34:39Z

[Term]
id: GO:0044725
name: chromatin reprogramming in the zygote
namespace: biological_process
def: "The global reprogramming of epigenetic modifications in the zygote following fertilization. The paternal genome undergoes active DNA demethylation before the first cell division, while the adjacent maternal genome is protected from this process." [GOC:sp, PMID:22868271]
is_a: GO:0043045 ! DNA methylation involved in embryo development
created_by: janelomax
creation_date: 2012-10-24T13:53:28Z

[Term]
id: GO:0044726
name: protection of DNA demethylation of female pronucleus
namespace: biological_process
def: "The protection of the maternal genome from DNA demethylation in the zygote following fertilization." [GOC:sp, PMID:22868271]
is_a: GO:0044030 ! regulation of DNA methylation
relationship: part_of GO:0044725 ! chromatin reprogramming in the zygote
created_by: janelomax
creation_date: 2012-10-24T14:10:36Z

[Term]
id: GO:0044727
name: DNA demethylation of male pronucleus
namespace: biological_process
def: "The active DNA demethylation of the paternal genome that takes place before the first cell division." [GOC:sp, PMID:22868271]
is_a: GO:0043045 ! DNA methylation involved in embryo development
relationship: part_of GO:0044725 ! chromatin reprogramming in the zygote
created_by: janelomax
creation_date: 2012-10-24T14:25:35Z

[Term]
id: GO:0044728
name: DNA methylation or demethylation
namespace: biological_process
def: "The process of adding or removing a methyl group from one or more nucleotides within an DNA molecule." [GOC:jl]
synonym: "changes in DNA methylation" RELATED []
is_a: GO:0006304 ! DNA modification
created_by: janelomax
creation_date: 2012-10-24T14:49:41Z

[Term]
id: GO:0044729
name: hemi-methylated DNA-binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with double-stranded hemi-methylated DNA at replication foci (one strand methylated, while the other strand is unmethylated). Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks." [GOC:imk, GOC:sp, PMID:18772889]
synonym: "double-stranded hemi-methylated DNA binding" EXACT []
is_a: GO:0003690 ! double-stranded DNA binding
created_by: janelomax
creation_date: 2012-10-24T14:58:14Z

[Term]
id: GO:0044730
name: bone sialoprotein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a bone sialoprotein, an extracellular matrix glycoprotein found on the surface of bones and dentin." [PMID:10642520]
synonym: "bone sialoprotein II binding" EXACT []
xref: InterPro:IPR008412
is_a: GO:0005515 ! protein binding
is_a: GO:0050840 ! extracellular matrix binding
created_by: janelomax
creation_date: 2012-11-06T13:05:56Z

[Term]
id: GO:0044731
name: Ost-alpha/Ost-beta complex
namespace: cellular_component
def: "A heterodimeric protein complex composed of Ost-alpha/SLC51A and Ost-beta/SLC51B subunits and involved in bile acid transport activity." [PMID:17650074, PMID:22535958]
synonym: "(Ost)2 complex" RELATED []
synonym: "Ost alpha-Ost beta complex" EXACT []
synonym: "SLC51 complex" EXACT []
is_a: GO:0098797 ! plasma membrane protein complex
created_by: janelomax
creation_date: 2012-11-06T13:42:06Z

[Term]
id: GO:0044732
name: mitotic spindle pole body
namespace: cellular_component
def: "The microtubule organizing center on a spindle that forms as part of mitosis; functionally homologous to the animal cell centrosome." [GOC:vw]
is_a: GO:0005816 ! spindle pole body
relationship: part_of GO:0072686 ! mitotic spindle
created_by: janelomax
creation_date: 2012-11-06T15:44:02Z

[Term]
id: GO:0044733
name: envenomation resulting in modulation of acid-sensing ion channel activity in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change in the activity of an acid-sensing ion channel (ASIC) in the bitten organism." [GOC:fj, GOC:jl, PMID:23034652]
synonym: "envenomation resulting in modulation of ASIC channel activity in other organism" EXACT []
is_a: GO:0044560 ! envenomation resulting in modulation of ion channel activity in other organism
relationship: has_part GO:0044737 ! modulation of acid-sensing ion channel in other organism
created_by: janelomax
creation_date: 2012-11-06T15:58:36Z

[Term]
id: GO:0044734
name: envenomation resulting in positive regulation of acid-sensing ion channel activity in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant positive regulation in the activity of an acid-sensing ion channel (ASIC) in the bitten organism." [GOC:fj, GOC:jl, PMID:23034652]
synonym: "envenomation resulting in positive regulation of ASIC channel activity in other organism" EXACT []
is_a: GO:0044733 ! envenomation resulting in modulation of acid-sensing ion channel activity in other organism
relationship: has_part GO:0044739 ! positive regulation of acid-sensing ion channel in other organism
created_by: janelomax
creation_date: 2012-11-06T16:02:01Z

[Term]
id: GO:0044735
name: envenomation resulting in negative regulation of acid-sensing ion channel activity in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant negative regulation in the activity of an acid-sensing ion channel (ASIC) in the bitten organism." [GOC:fj, GOC:jl, PMID:23034652]
synonym: "envenomation resulting in negative regulation of ASIC channel activity in other organism" EXACT []
is_a: GO:0044733 ! envenomation resulting in modulation of acid-sensing ion channel activity in other organism
relationship: has_part GO:0044738 ! negative regulation of acid-sensing ion channel in other organism
created_by: janelomax
creation_date: 2012-11-06T16:05:58Z

[Term]
id: GO:0044736
name: acid-sensing ion channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a sodium ion by a neuronal, voltage-insensitive channel that opens when a an extracellular proton has been bound by the channel complex." [GOC:jl]
synonym: "ASIC activity" EXACT []
xref: Wikipedia:Acid-sensing_ion_channel
is_a: GO:0015280 ! ligand-gated sodium channel activity
created_by: janelomax
creation_date: 2012-11-06T16:36:37Z

[Term]
id: GO:0044737
name: modulation of acid-sensing ion channel in other organism
namespace: biological_process
def: "Any process in which an organism effects a change in the frequency, rate or extent of the activity of an acid-sensing ion channel (ASIC) in another organism." [GOC:jl]
synonym: "regulation of acid-sensing ion channel in other organism" EXACT []
synonym: "regulation of ASIC channel in other organism" EXACT []
is_a: GO:0044561 ! modulation of ion channel activity in other organism
created_by: janelomax
creation_date: 2012-11-06T16:51:24Z

[Term]
id: GO:0044738
name: negative regulation of acid-sensing ion channel in other organism
namespace: biological_process
def: "Any process in which an organism negatively regulates the activity of a voltage-gated sodium channel in another organism." [GOC:jl]
synonym: "negative regulation of ASIC channel in other organism" EXACT []
is_a: GO:0032410 ! negative regulation of transporter activity
is_a: GO:0044737 ! modulation of acid-sensing ion channel in other organism
created_by: janelomax
creation_date: 2012-11-06T16:55:23Z

[Term]
id: GO:0044739
name: positive regulation of acid-sensing ion channel in other organism
namespace: biological_process
def: "Any process in which an organism positively regulates the activity of a voltage-gated sodium channel in another organism." [GOC:jl]
synonym: "positive regulation of ASIC channel in other organism" EXACT []
is_a: GO:0032411 ! positive regulation of transporter activity
is_a: GO:0044737 ! modulation of acid-sensing ion channel in other organism
created_by: janelomax
creation_date: 2012-11-06T16:56:27Z

[Term]
id: GO:0044740
name: negative regulation of sensory perception of pain in other organism
namespace: biological_process
def: "A process that negatively regulates the sensory perception of pain in a different organism." [GOC:fj, GOC:jl]
synonym: "inhibition of sensory perception of pain in another organism" EXACT []
is_a: GO:0031645 ! negative regulation of neurological system process
is_a: GO:0044465 ! modulation of sensory perception of pain in other organism
created_by: janelomax
creation_date: 2012-11-07T13:43:10Z

[Term]
id: GO:0044741
name: envenomation resulting in negative regulation of sensory perception of pain in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the inhibition of the sensory perception of pain in the bitten organism." [GOC:fj, GOC:jl, PMID:23034652]
synonym: "envenomation resulting in inhibition of sensory perception of pain in other organism" EXACT []
is_a: GO:0044742 ! envenomation resulting in modulation of sensory perception of pain in other organism
relationship: has_part GO:0044740 ! negative regulation of sensory perception of pain in other organism
created_by: janelomax
creation_date: 2012-11-07T14:02:14Z

[Term]
id: GO:0044742
name: envenomation resulting in modulation of sensory perception of pain in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the modulation of the sensory perception of pain in the bitten organism." [GOC:fj, GOC:jl, PMID:23034652]
synonym: "envenomation resulting in regulation of sensory perception of pain in other organism" EXACT []
is_a: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism
relationship: has_part GO:0044465 ! modulation of sensory perception of pain in other organism
created_by: janelomax
creation_date: 2012-11-07T14:26:38Z

[Term]
id: GO:0044743
name: intracellular protein transmembrane import
namespace: biological_process
def: "The directed movement of proteins into an intracellular organelle, across a membrane." [GOC:jl]
is_a: GO:0017038 ! protein import
is_a: GO:0065002 ! intracellular protein transmembrane transport
created_by: janelomax
creation_date: 2012-11-07T15:37:36Z

[Term]
id: GO:0044744
name: protein targeting to nucleus
namespace: biological_process
def: "The process of directing proteins towards the nucleus, usually using signals contained within the protein." [GOC:jl]
is_a: GO:0006605 ! protein targeting
is_a: GO:0034504 ! protein localization to nucleus
is_a: GO:0051169 ! nuclear transport
is_a: GO:0072594 ! establishment of protein localization to organelle
is_a: GO:1902580 ! single-organism cellular localization
created_by: janelomax
creation_date: 2012-11-07T15:45:54Z

[Term]
id: GO:0044745
name: amino acid transmembrane import
namespace: biological_process
def: "The directed movement of amino acids into a cell or organelle, across a membrane." [GOC:jl]
is_a: GO:0003333 ! amino acid transmembrane transport
is_a: GO:0043090 ! amino acid import
created_by: janelomax
creation_date: 2012-11-14T14:21:41Z

[Term]
id: GO:0044746
name: amino acid transmembrane export
namespace: biological_process
def: "The directed movement of amino acids out of a cell or organelle across a membrane." [GOC:jl]
is_a: GO:0003333 ! amino acid transmembrane transport
is_a: GO:0032973 ! amino acid export
created_by: janelomax
creation_date: 2012-11-14T14:27:40Z

[Term]
id: GO:0044747
name: mature miRNA 3'-end processing
namespace: biological_process
def: "Any process involved in forming distinct miRNA isoforms from a mature miRNA that differ at their 3'-ends." [PMID:22055292, PMID:22055293]
synonym: "miRNA 3' end terminal trimming" BROAD []
synonym: "miRNA 3'-end processing" BROAD []
synonym: "miRNA trimming" BROAD []
is_a: GO:0010586 ! miRNA metabolic process
is_a: GO:0043628 ! ncRNA 3'-end processing
relationship: part_of GO:0035196 ! production of miRNAs involved in gene silencing by miRNA
created_by: janelomax
creation_date: 2012-11-15T13:45:21Z

[Term]
id: GO:0044748
name: 3'-5'-exoribonuclease activity involved in mature miRNA 3'-end processing
namespace: molecular_function
def: "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule that contributes to forming distinct miRNA isoforms from a mature miRNA." [GOC:sart]
synonym: "exonucleolytic trimming to generate 3' end of miRNA" BROAD []
is_a: GO:0000175 ! 3'-5'-exoribonuclease activity
intersection_of: GO:0000175 ! 3'-5'-exoribonuclease activity
intersection_of: part_of GO:0044747 ! mature miRNA 3'-end processing
relationship: part_of GO:0044747 ! mature miRNA 3'-end processing
created_by: janelomax
creation_date: 2012-11-20T13:48:29Z

[Term]
id: GO:0044749
name: high-affinity zinc II ion transmembrane import
namespace: biological_process
def: "The directed, high-affinity movement of zinc (Zn II) ions across a membrane into a cell or organelle. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:jl]
is_a: GO:0071578 ! zinc II ion transmembrane import
created_by: janelomax
creation_date: 2012-11-20T15:01:05Z

[Term]
id: GO:0044750
name: high-affinity nickel cation transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the high-affinity transfer of nickel (Ni) cations from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:jl]
is_a: GO:0015099 ! nickel cation transmembrane transporter activity
created_by: janelomax
creation_date: 2012-11-20T15:15:59Z

[Term]
id: GO:0044751
name: cellular response to human chorionic gonadotropin stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a human chorionic gonadotropin stimulus." [PMID:21325635]
synonym: "cellular response to human chorionic gonadotrophin stimulus" EXACT [GOC:dph]
is_a: GO:0044752 ! response to human chorionic gonadotropin
is_a: GO:0071371 ! cellular response to gonadotropin stimulus
created_by: janelomax
creation_date: 2012-11-20T16:19:45Z

[Term]
id: GO:0044752
name: response to human chorionic gonadotropin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a human chorionic gonadotropin stimulus." [PMID:21325635]
synonym: "response to human chorionic gonadotropin stimulus" EXACT [GOC:dos]
is_a: GO:0034698 ! response to gonadotropin
created_by: janelomax
creation_date: 2012-11-20T16:21:08Z

[Term]
id: GO:0044753
name: amphisome
namespace: cellular_component
def: "An autophagosome formed upon fusion between autophagosomes and endosomes." [GOC:autophagy, GOC:sart, PMID:19008921, PMID:9705327]
is_a: GO:0005776 ! autophagosome
created_by: janelomax
creation_date: 2012-11-27T15:35:25Z

[Term]
id: GO:0044754
name: autolysosome
namespace: cellular_component
def: "A type of secondary lysosome in which a primary lysosome has fused with the outer membrane of an autophagosome. It is involved in the second step of autophagy in which it degrades contents with acidic lysosomal hydrolases." [GOC:sart, NIF_Subcellular:sao8444068431, PMID:19008921]
synonym: "autophagolysosome" EXACT []
synonym: "AVd" EXACT []
synonym: "degrading autophagic vacuole" EXACT []
xref: NIF_Subcellular:sao8444068431
is_a: GO:0005767 ! secondary lysosome
is_a: GO:0005776 ! autophagosome
created_by: janelomax
creation_date: 2012-11-27T15:42:12Z

[Term]
id: GO:0044755
name: pantothenate import into cell
namespace: biological_process
def: "The directed movement of pantothenate from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [GOC:jl]
is_a: GO:0098657 ! import into cell
is_a: GO:1901688 ! pantothenate import
created_by: janelomax
creation_date: 2012-12-06T13:02:23Z

[Term]
id: GO:0044756
name: biotin import into cell
namespace: biological_process
def: "The directed movement of biotin from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [GOC:jl]
is_a: GO:0098657 ! import into cell
is_a: GO:1901689 ! biotin import
created_by: janelomax
creation_date: 2012-12-06T13:04:45Z

[Term]
id: GO:0044757
name: dethiobiotin import into cell
namespace: biological_process
def: "The directed movement of dethiobiotin from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [GOC:jl]
is_a: GO:0098657 ! import into cell
is_a: GO:1901690 ! dethiobiotin import
created_by: janelomax
creation_date: 2012-12-06T13:06:28Z

[Term]
id: GO:0044758
name: modulation by symbiont of host synaptic transmission
namespace: biological_process
def: "Any process in which a symbiont organism modulates the frequency, rate or extent of synaptic transmission, communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse, in its host organism." [GOC:jl]
subset: gosubset_prok
synonym: "regulation by symbiont of host synaptic transmission" EXACT []
is_a: GO:0044063 ! modulation by symbiont of host neurological system process
is_a: GO:0044068 ! modulation by symbiont of host cellular process
is_a: GO:0050804 ! modulation of synaptic transmission
created_by: janelomax
creation_date: 2012-12-06T15:34:05Z

[Term]
id: GO:0044759
name: negative regulation by symbiont of host synaptic transmission
namespace: biological_process
def: "Any process in which a symbiont organism modulates the frequency, rate or extent of synaptic transmission, communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse, in its host organism." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044758 ! modulation by symbiont of host synaptic transmission
is_a: GO:0050805 ! negative regulation of synaptic transmission
created_by: janelomax
creation_date: 2012-12-06T15:37:25Z

[Term]
id: GO:0044760
name: modulation by symbiont of host cholinergic synaptic transmission
namespace: biological_process
def: "Any process in which a symbiont organism modulates the frequency, rate or extent of cholinergic synaptic transmission, communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse via the neurotransmitter choline, in its host organism." [GOC:jl]
subset: gosubset_prok
synonym: "regulation by symbiont of host cholinergic synaptic transmission" EXACT []
is_a: GO:0032222 ! regulation of synaptic transmission, cholinergic
is_a: GO:0044758 ! modulation by symbiont of host synaptic transmission
created_by: janelomax
creation_date: 2012-12-06T15:39:46Z

[Term]
id: GO:0044761
name: negative regulation by symbiont of host cholinergic synaptic transmission
namespace: biological_process
def: "Any process in which a symbiont organism negatively regulates cholinergic synaptic transmission, communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse via the neurotransmitter choline, in its host organism." [GOC:jl]
subset: gosubset_prok
is_a: GO:0032223 ! negative regulation of synaptic transmission, cholinergic
is_a: GO:0044759 ! negative regulation by symbiont of host synaptic transmission
is_a: GO:0044760 ! modulation by symbiont of host cholinergic synaptic transmission
created_by: janelomax
creation_date: 2012-12-06T15:43:53Z

[Term]
id: GO:0044762
name: negative regulation by symbiont of host neurotransmitter secretion
namespace: biological_process
def: "Any process in which a symbiont organism negatively regulates the regulated release of a neurotransmitter from a cell in its host organism." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044079 ! modulation by symbiont of host neurotransmitter secretion
is_a: GO:0046929 ! negative regulation of neurotransmitter secretion
created_by: janelomax
creation_date: 2012-12-06T15:52:20Z

[Term]
id: GO:0044763
name: single-organism cellular process
namespace: biological_process
def: "Any process that is carried out at the cellular level, occurring within a single organism." [GOC:jl]
is_a: GO:0009987 ! cellular process
is_a: GO:0044699 ! single-organism process
created_by: janelomax
creation_date: 2012-12-11T16:56:55Z

[Term]
id: GO:0044764
name: multi-organism cellular process
namespace: biological_process
def: "Any process that is carried out at the cellular level which involves another organism of the same or different species." [GOC:jl]
is_a: GO:0009987 ! cellular process
is_a: GO:0051704 ! multi-organism process
created_by: janelomax
creation_date: 2012-12-11T17:00:50Z

[Term]
id: GO:0044765
name: single-organism transport
namespace: biological_process
def: "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore, involving a single organism." [GOC:jl]
is_a: GO:0006810 ! transport
is_a: GO:1902578 ! single-organism localization
created_by: janelomax
creation_date: 2012-12-13T16:25:32Z

[Term]
id: GO:0044766
name: multi-organism transport
namespace: biological_process
def: "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore, involving more than one organism." [GOC:jl]
is_a: GO:0006810 ! transport
is_a: GO:1902579 ! multi-organism localization
created_by: janelomax
creation_date: 2012-12-13T16:25:50Z

[Term]
id: GO:0044767
name: single-organism developmental process
namespace: biological_process
def: "A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition, involving only one organism." [GOC:jl]
is_a: GO:0032502 ! developmental process
is_a: GO:0044699 ! single-organism process
created_by: janelomax
creation_date: 2012-12-19T12:21:31Z

[Term]
id: GO:0044768
name: NMS complex assembly involved in kinetochore assembly
namespace: biological_process
def: "The formation of a supercomplex by the association of two subcomplexes (known as MIND and Ndc80 in Schizosaccharomyces) that is required for kinetochore assembly." [PMID:22561345]
synonym: "KMN complex interaction involved in chromosome segregation" EXACT []
synonym: "KMN network assembly involved in chromosome segregation" EXACT []
synonym: "NMS complex association involved in chromosome segregation" EXACT []
is_a: GO:0006461 ! protein complex assembly
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0051382 ! kinetochore assembly
created_by: janelomax
creation_date: 2012-12-19T14:44:56Z

[Term]
id: GO:0044769
name: ATPase activity, coupled to transmembrane movement of ions, rotational mechanism
namespace: molecular_function
def: "Catalysis of the transfer of ions from one side of a membrane to the other according to the reaction: ATP + H2O + ion(in) = ADP + phosphate + ion(out), by a rotational mechanism." [GOC:jl]
is_a: GO:0042625 ! ATPase coupled ion transmembrane transporter activity
created_by: janelomax
creation_date: 2013-02-20T13:41:38Z

[Term]
id: GO:0044770
name: cell cycle phase transition
namespace: biological_process
def: "The cell cycle process by which a cell commits to entering the next cell cycle phase." [GOC:mtg_cell_cycle]
synonym: "cell cycle transition" EXACT []
is_a: GO:0022402 ! cell cycle process
created_by: janelomax
creation_date: 2013-02-28T12:54:59Z

[Term]
id: GO:0044771
name: meiotic cell cycle phase transition
namespace: biological_process
def: "The cell cycle process by which a cell commits to entering the next meiotic cell cycle phase." [GOC:mtg_cell_cycle]
synonym: "cell cycle transition" BROAD []
is_a: GO:0044770 ! cell cycle phase transition
is_a: GO:1903046 ! meiotic cell cycle process
intersection_of: GO:0044770 ! cell cycle phase transition
intersection_of: part_of GO:0051321 ! meiotic cell cycle
relationship: part_of GO:0051321 ! meiotic cell cycle
created_by: janelomax
creation_date: 2013-02-28T13:08:17Z

[Term]
id: GO:0044772
name: mitotic cell cycle phase transition
namespace: biological_process
def: "The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase." [GOC:mtg_cell_cycle]
is_a: GO:0044770 ! cell cycle phase transition
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0044770 ! cell cycle phase transition
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0000278 ! mitotic cell cycle
created_by: janelomax
creation_date: 2013-02-28T13:09:33Z

[Term]
id: GO:0044773
name: mitotic DNA damage checkpoint
namespace: biological_process
def: "A mitotic cell cycle checkpoint that detects and negatively regulates progression through the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle]
is_a: GO:0000077 ! DNA damage checkpoint
is_a: GO:0044774 ! mitotic DNA integrity checkpoint
intersection_of: GO:0000077 ! DNA damage checkpoint
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0000278 ! mitotic cell cycle
created_by: janelomax
creation_date: 2013-02-28T15:55:25Z

[Term]
id: GO:0044774
name: mitotic DNA integrity checkpoint
namespace: biological_process
alt_id: GO:0070683
def: "A mitotic cell cycle process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and ends with signal transduction." [GOC:mtg_cell_cycle]
synonym: "mitotic cell cycle G2/M transition decatenation checkpoint" EXACT []
synonym: "topo II checkpoint" EXACT [GOC:jp]
synonym: "topoisomerase II checkpoint" EXACT [GOC:jp]
is_a: GO:0007093 ! mitotic cell cycle checkpoint
is_a: GO:0031570 ! DNA integrity checkpoint
intersection_of: GO:0031570 ! DNA integrity checkpoint
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0000278 ! mitotic cell cycle
created_by: janelomax
creation_date: 2013-02-28T16:07:26Z

[Term]
id: GO:0044775
name: DNA polymerase III, beta sliding clamp processivity factor complex
namespace: cellular_component
def: "A subcomplex of the DNA polymerase III holoenzyme which is responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. The complex is homodimeric in prokaryotes, and homotrimeric in other species." [GOC:jl, UniProt:O73947]
is_a: GO:0044796 ! DNA polymerase processivity factor complex
relationship: part_of GO:0009360 ! DNA polymerase III complex
created_by: janelomax
creation_date: 2013-03-13T13:59:48Z

[Term]
id: GO:0044776
name: DNA polymerase III, core complex
namespace: cellular_component
def: "The DNA polymerase III core complex consists of the alpha,epsilon and theta subunits and is carries out the polymerase and the 3'-5' exonuclease proofreading activities." [GOC:jl, UniProt:P06710]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0009360 ! DNA polymerase III complex
created_by: janelomax
creation_date: 2013-03-13T14:09:38Z

[Term]
id: GO:0044777
name: single-stranded DNA-binding protein complex
namespace: cellular_component
def: "A homotetrameric protein complex that is essential for DNA replication. It supercoils the single-stranded DNA preventing DNA duplexing before the polymerase holoenzyme passes and synthesizes the complementary strand. It is also involved in DNA recombination and repair." [GOC:jl, UniProt:P0AGE0]
synonym: "SSB complex" EXACT []
is_a: GO:0043234 ! protein complex
relationship: part_of GO:0009295 ! nucleoid
created_by: janelomax
creation_date: 2013-03-14T13:14:00Z

[Term]
id: GO:0044778
name: meiotic DNA integrity checkpoint
namespace: biological_process
def: "A meiotic cell cycle process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and ends with signal transduction." [GOC:mtg_cell_cycle]
is_a: GO:0031570 ! DNA integrity checkpoint
is_a: GO:0033313 ! meiotic cell cycle checkpoint
intersection_of: GO:0031570 ! DNA integrity checkpoint
intersection_of: part_of GO:0051321 ! meiotic cell cycle
relationship: part_of GO:0051321 ! meiotic cell cycle
created_by: janelomax
creation_date: 2013-03-20T16:46:06Z

[Term]
id: GO:0044779
name: meiotic spindle checkpoint
namespace: biological_process
def: "A cell cycle checkpoint that delays the metaphase/anaphase transition of a meiotic nuclear division until the spindle is correctly assembled and that the chromosomes are attached to the spindle." [GOC:mtg_cell_cycle]
is_a: GO:0031577 ! spindle checkpoint
is_a: GO:0033313 ! meiotic cell cycle checkpoint
is_a: GO:1902103 ! negative regulation of metaphase/anaphase transition of meiotic cell cycle
intersection_of: GO:0031577 ! spindle checkpoint
intersection_of: part_of GO:0051321 ! meiotic cell cycle
relationship: part_of GO:0051321 ! meiotic cell cycle
created_by: janelomax
creation_date: 2013-03-21T14:01:28Z

[Term]
id: GO:0044780
name: bacterial-type flagellum assembly
namespace: biological_process
def: "The assembly of a bacterial-type flagellum, a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope which functions in cell motility." [GOC:jl]
synonym: "bacterial flagellum assembly" EXACT []
is_a: GO:0030031 ! cell projection assembly
is_a: GO:0044781 ! bacterial-type flagellum organization
is_a: GO:0070925 ! organelle assembly
created_by: janelomax
creation_date: 2013-03-27T15:00:43Z

[Term]
id: GO:0044781
name: bacterial-type flagellum organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a bacterial-type flagellum, a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope which functions in cell motility." [GOC:jl]
is_a: GO:0030030 ! cell projection organization
is_a: GO:1902589 ! single-organism organelle organization
created_by: janelomax
creation_date: 2013-03-27T15:07:00Z

[Term]
id: GO:0044782
name: cilium organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:jl]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.
synonym: "microtubule-based flagellum organization" EXACT []
is_a: GO:0030030 ! cell projection organization
is_a: GO:1902589 ! single-organism organelle organization
created_by: janelomax
creation_date: 2013-03-27T15:09:58Z

[Term]
id: GO:0044783
name: G1 DNA damage checkpoint
namespace: biological_process
def: "A cell cycle checkpoint that detects and negatively regulates progression from G1 to S phase in the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle]
synonym: "G1/S DNA damage checkpoint" EXACT []
is_a: GO:0000077 ! DNA damage checkpoint
created_by: janelomax
creation_date: 2013-05-02T12:52:39Z

[Term]
id: GO:0044784
name: metaphase/anaphase transition of cell cycle
namespace: biological_process
def: "The cell cycle process in which a cell progresses from metaphase to anaphase as part of the cell cycle." [GOC:mtg_cell_cycle]
is_a: GO:0033045 ! regulation of sister chromatid segregation
is_a: GO:0044770 ! cell cycle phase transition
created_by: janelomax
creation_date: 2013-05-02T13:09:34Z

[Term]
id: GO:0044785
name: metaphase/anaphase transition of meiotic cell cycle
namespace: biological_process
def: "The cell cycle process in which a cell progresses from metaphase to anaphase as part of meiosis." [GOC:mtg_cell_cycle]
synonym: "meiotic metaphase/anaphase transition" EXACT []
is_a: GO:0044771 ! meiotic cell cycle phase transition
is_a: GO:0044784 ! metaphase/anaphase transition of cell cycle
intersection_of: GO:0044784 ! metaphase/anaphase transition of cell cycle
intersection_of: part_of GO:0051321 ! meiotic cell cycle
relationship: part_of GO:0051321 ! meiotic cell cycle
created_by: janelomax
creation_date: 2013-05-02T13:11:28Z

[Term]
id: GO:0044786
name: cell cycle DNA replication
namespace: biological_process
def: "The DNA-dependent DNA replication that takes place as part of the cell cycle." [GOC:mtg_cell_cycle]
is_a: GO:0006261 ! DNA-dependent DNA replication
is_a: GO:0022402 ! cell cycle process
is_a: GO:0044711 ! single-organism biosynthetic process
intersection_of: GO:0006261 ! DNA-dependent DNA replication
intersection_of: part_of GO:0007049 ! cell cycle
relationship: part_of GO:0007049 ! cell cycle
created_by: janelomax
creation_date: 2013-05-02T15:52:22Z

[Term]
id: GO:0044787
name: bacterial-type DNA replication
namespace: biological_process
def: "The DNA-dependent DNA replication, exemplified by prokaryotes, that occurs as part of the cell cycle. Prokaryotic DNA replication is bi-directional and originates at a single origin of replication on the circular genome." [GOC:mtg_cell_cycle]
synonym: "bacterial-type cell cycle DNA replication" EXACT []
is_a: GO:0044786 ! cell cycle DNA replication
created_by: janelomax
creation_date: 2013-05-02T15:54:16Z

[Term]
id: GO:0044788
name: modulation by host of viral process
namespace: biological_process
def: "A process in which a host organism modulates the frequency, rate or extent of any of a process being mediated by a virus with which it is infected." [GOC:jl]
subset: virus_checked
is_a: GO:0051851 ! modification by host of symbiont morphology or physiology
created_by: janelomax
creation_date: 2013-06-06T10:50:49Z

[Term]
id: GO:0044789
name: modulation by host of viral release from host cell
namespace: biological_process
def: "A process in which a host organism modulates the frequency, rate or extent of the release of a virus with which it is infected, from its cells." [GOC:jl, PMID:18305167]
is_a: GO:0044788 ! modulation by host of viral process
is_a: GO:1902186 ! regulation of viral release from host cell
intersection_of: GO:0044788 ! modulation by host of viral process
intersection_of: regulates GO:0019076 ! viral release from host cell
relationship: regulates GO:0019076 ! viral release from host cell
created_by: janelomax
creation_date: 2013-06-06T10:51:10Z

[Term]
id: GO:0044790
name: negative regulation by host of viral release from host cell
namespace: biological_process
def: "A process in which a host organism stops, prevents or reduces the frequency, rate or extent of the release of a virus with which it is infected, from its cells." [GOC:jl, PMID:18305167]
subset: virus_checked
is_a: GO:0044789 ! modulation by host of viral release from host cell
is_a: GO:0044793 ! negative regulation by host of viral process
is_a: GO:1902187 ! negative regulation of viral release from host cell
intersection_of: GO:0044793 ! negative regulation by host of viral process
intersection_of: negatively_regulates GO:0019076 ! viral release from host cell
relationship: negatively_regulates GO:0019076 ! viral release from host cell
created_by: janelomax
creation_date: 2013-06-06T10:51:27Z

[Term]
id: GO:0044791
name: positive regulation by host of viral release from host cell
namespace: biological_process
def: "A process in which a host organism activates or increases the frequency, rate or extent of the release of a virus with which it is infected, from its cells." [GOC:jl]
is_a: GO:0044789 ! modulation by host of viral release from host cell
is_a: GO:0044794 ! positive regulation by host of viral process
is_a: GO:1902188 ! positive regulation of viral release from host cell
intersection_of: GO:0044794 ! positive regulation by host of viral process
intersection_of: positively_regulates GO:0019076 ! viral release from host cell
relationship: positively_regulates GO:0019076 ! viral release from host cell
created_by: janelomax
creation_date: 2013-06-06T10:51:48Z

[Term]
id: GO:0044793
name: negative regulation by host of viral process
namespace: biological_process
def: "A process in which a host organism stops, prevents or reduces the frequency, rate or extent of a process being mediated by a virus with which it is infected." [GOC:jl]
subset: virus_checked
is_a: GO:0044788 ! modulation by host of viral process
is_a: GO:0048525 ! negative regulation of viral process
intersection_of: GO:0044788 ! modulation by host of viral process
intersection_of: negatively_regulates GO:0016032 ! viral process
relationship: negatively_regulates GO:0016032 ! viral process
created_by: janelomax
creation_date: 2013-06-06T11:16:00Z

[Term]
id: GO:0044794
name: positive regulation by host of viral process
namespace: biological_process
def: "A process in which a host organism activates or increases the frequency, rate or extent of the release of a process being mediated by a virus with which it is infected." [GOC:jl]
is_a: GO:0044788 ! modulation by host of viral process
is_a: GO:0048524 ! positive regulation of viral process
intersection_of: GO:0044788 ! modulation by host of viral process
intersection_of: positively_regulates GO:0016032 ! viral process
relationship: positively_regulates GO:0016032 ! viral process
created_by: janelomax
creation_date: 2013-06-06T11:33:51Z

[Term]
id: GO:0044795
name: trans-Golgi network to recycling endosome transport
namespace: biological_process
def: "The directed movement of substances, in membrane-bounded vesicles, from the trans-Golgi network to the recycling endosomes." [GOC:lb, PMID:18779367]
is_a: GO:0016197 ! endosomal transport
created_by: janelomax
creation_date: 2013-08-27T16:04:00Z

[Term]
id: GO:0044796
name: DNA polymerase processivity factor complex
namespace: cellular_component
def: "A protein complex which is capable of increasing the processivity of nucleotide polymerization by DNA polymerase as a part of DNA replication." [GOC:bhm, GOC:jl]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
created_by: janelomax
creation_date: 2013-08-28T11:16:14Z

[Term]
id: GO:0044797
name: cytoplasmic transcription factor complex
namespace: cellular_component
def: "A protein complex, located in the cytoplasm, that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl]
is_a: GO:0005667 ! transcription factor complex
is_a: GO:0044444 ! cytoplasmic part
intersection_of: GO:0005667 ! transcription factor complex
intersection_of: part_of GO:0005737 ! cytoplasm
relationship: part_of GO:0005737 ! cytoplasm
created_by: janelomax
creation_date: 2013-08-28T12:11:37Z

[Term]
id: GO:0044798
name: nuclear transcription factor complex
namespace: cellular_component
def: "A protein complex, located in the nucleus, that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl]
is_a: GO:0005667 ! transcription factor complex
is_a: GO:0044428 ! nuclear part
intersection_of: GO:0005667 ! transcription factor complex
intersection_of: part_of GO:0005634 ! nucleus
relationship: part_of GO:0005634 ! nucleus
created_by: janelomax
creation_date: 2013-08-28T12:12:27Z

[Term]
id: GO:0044799
name: NarGHI complex
namespace: cellular_component
def: "A heterotrimeric protein complex with iron-sulfur and molybdenum cofactors that functions as a terminal reductase in electron transport pathways that operate during anaerobic nitrate respiration. In E. coli electrons are passed from the FdnGHI complex to the NarGHI complex via menoquinone and menaquinol. Within NarGHI, electrons are passed from the two heme molecules in the NarI subunit down a Fe-S cluster chain in the NarH and NarG subunits to the Molybdenum cofactor, Mo-bisMGD, in the NarG subunit." [GOC:bhm, PMID:11289299, PMID:12910261, PMID:17964535]
synonym: "cytoplasmic membrane-bound quinol-nitrate oxidoreductase" EXACT []
synonym: "nitrate reductase A" EXACT []
is_a: GO:0009325 ! nitrate reductase complex
is_a: GO:0098797 ! plasma membrane protein complex
is_a: GO:0098803 ! respiratory chain complex
relationship: part_of GO:0005887 ! integral component of plasma membrane
relationship: part_of GO:0070470 ! plasma membrane respiratory chain
created_by: janelomax
creation_date: 2013-08-29T14:17:41Z

[Term]
id: GO:0044800
name: multi-organism membrane fusion
namespace: biological_process
def: "The membrane organization process that joins two lipid bilayers to form a single membrane, involving more than one organism." [GOC:jl]
is_a: GO:0044803 ! multi-organism membrane organization
is_a: GO:0061025 ! membrane fusion
created_by: janelomax
creation_date: 2013-09-10T15:06:11Z

[Term]
id: GO:0044801
name: single-organism membrane fusion
namespace: biological_process
def: "The membrane organization process that joins two lipid bilayers to form a single membrane, involving only one organism." [GOC:jl]
is_a: GO:0044802 ! single-organism membrane organization
is_a: GO:0061025 ! membrane fusion
created_by: janelomax
creation_date: 2013-09-10T15:08:20Z

[Term]
id: GO:0044802
name: single-organism membrane organization
namespace: biological_process
def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane, involving only one organism." [GOC:jl]
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0061024 ! membrane organization
created_by: janelomax
creation_date: 2013-09-10T15:11:17Z

[Term]
id: GO:0044803
name: multi-organism membrane organization
namespace: biological_process
def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane, involving more than one organism." [GOC:jl]
is_a: GO:0044764 ! multi-organism cellular process
is_a: GO:0061024 ! membrane organization
created_by: janelomax
creation_date: 2013-09-10T15:11:41Z

[Term]
id: GO:0044804
name: nucleophagy
namespace: biological_process
def: "A selective form of autophagy, by which damaged or non-essential parts of the nucleus, or even an entire nucleus is degraded." [GOC:autophagy, GOC:jl, PMID:24013549]
synonym: "nucleus degradation" EXACT []
is_a: GO:0006914 ! autophagy
created_by: janelomax
creation_date: 2013-09-10T15:50:25Z

[Term]
id: GO:0044805
name: late nucleophagy
namespace: biological_process
def: "A type of nucleophagy, distinct from piecemeal microautophagy of the nucleus (PNM) where the nuclear material is delivered to the vacuole/lysosome for breakdown and recycling later than observed for PNM." [GOC:dgf, GOC:jl, PMID:22768199]
synonym: "LN" EXACT []
is_a: GO:0044804 ! nucleophagy
created_by: janelomax
creation_date: 2013-09-10T15:58:23Z

[Term]
id: GO:0044806
name: G-quadruplex DNA unwinding
namespace: biological_process
def: "The process by which G-quadruplex (also known as G4) DNA, which is a four-stranded DNA structure held together by guanine base pairing, is unwound or 'melted'." [GOC:jl, GOC:se, PMID:23657261]
is_a: GO:0032392 ! DNA geometric change
created_by: janelomax
creation_date: 2013-09-10T16:16:16Z

[Term]
id: GO:0044807
name: macrophage migration inhibitory factor production
namespace: biological_process
def: "The appearance of macrophage migration inhibitory factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv]
synonym: "MIF production" EXACT []
is_a: GO:0001816 ! cytokine production
created_by: janelomax
creation_date: 2013-09-11T12:04:09Z

[Term]
id: GO:0044808
name: Oncostatin M production
namespace: biological_process
def: "The appearance of Oncostatin M due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv]
synonym: "OSM production" EXACT []
is_a: GO:0001816 ! cytokine production
created_by: janelomax
creation_date: 2013-09-11T12:18:00Z

[Term]
id: GO:0044809
name: chemokine (C-C motif) ligand 17 production
namespace: biological_process
def: "The appearance of chemokine (C-C motif) ligand 17 (CCL17) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv]
synonym: "CCL17 production" EXACT []
synonym: "TARC production" EXACT []
synonym: "thymus and activation regulated chemokine production" EXACT []
is_a: GO:0032602 ! chemokine production
created_by: janelomax
creation_date: 2013-09-11T12:21:31Z

[Term]
id: GO:0044810
name: Dma1-dependent checkpoint
namespace: biological_process
def: "Mitotic cell cycle spindle checkpoint that negatively regulates cytokinesis and mitotic exit when the spindle does not form." [GOC:mtg_cell_cycle]
synonym: "SAC-independent checkpoint" EXACT []
is_a: GO:0071174 ! mitotic spindle checkpoint
created_by: janelomax
creation_date: 2013-09-12T15:18:28Z

[Term]
id: GO:0044811
name: response to Dma1-dependent checkpoint signaling
namespace: biological_process
def: "A process that occurs in response to signals generated as a result of Dma1-dependent checkpoint signalling." [GOC:mtg_cell_cycle]
synonym: "response to Dma1-dependent checkpoint signalling" EXACT []
is_a: GO:0072476 ! response to mitotic spindle checkpoint signaling
created_by: janelomax
creation_date: 2013-09-17T16:31:05Z

[Term]
id: GO:0044812
name: fermentative hydrogen production
namespace: biological_process
def: "The fermentation of organic substances with a net release of hydrogen." [GOC:mengo_curators]
synonym: "carbohydrate fermentation" EXACT []
xref: GOC:mengo_curators
xref: Wikipedia:Fermentative_hydrogen_production
is_a: GO:0006113 ! fermentation
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:1902422 ! hydrogen biosynthetic process
created_by: janelomax
creation_date: 2013-09-18T14:09:47Z

[Term]
id: GO:0044813
name: glycolytic fermentation via PFOR pathway
namespace: biological_process
def: "The glycolytic fermentation beginning with the anaerobic conversion of glucose to pyruvate by the glycolytic pathway, continuing with pyruvate:ferredoxin oxidoreductase (PFOR) activity. This pathway is found in strict anaerobes such as Clostridia species." [GOC:mengo_curators, PMID:20395274, PMID:20692761]
is_a: GO:0019660 ! glycolytic fermentation
intersection_of: GO:0019660 ! glycolytic fermentation
intersection_of: has_part GO:0019164 ! pyruvate synthase activity
relationship: has_part GO:0019164 ! pyruvate synthase activity
created_by: janelomax
creation_date: 2013-09-18T16:04:00Z

[Term]
id: GO:0044814
name: glycolytic fermentation via PFL pathway
namespace: biological_process
def: "The glycolytic fermentation beginning with the anaerobic conversion of glucose to pyruvate by the glycolytic pathway, followed by pyruvate:formate lyase (PFL) activity. This pathway is found in facultative anaerobes such as E. coli." [GOC:mengo_curators, PMID:20395274, PMID:20692761]
is_a: GO:0019660 ! glycolytic fermentation
intersection_of: GO:0019660 ! glycolytic fermentation
intersection_of: has_part GO:0008861 ! formate C-acetyltransferase activity
relationship: has_part GO:0008861 ! formate C-acetyltransferase activity
created_by: janelomax
creation_date: 2013-09-18T16:56:02Z

[Term]
id: GO:0044815
name: DNA packaging complex
namespace: cellular_component
def: "A protein complex that plays a role in the process of DNA packaging." [GOC:jl]
is_a: GO:0043234 ! protein complex
created_by: janelomax
creation_date: 2013-09-19T11:33:45Z

[Term]
id: GO:0044816
name: Nsk1-Dlc1 complex
namespace: cellular_component
def: "A dimer of Nsk1 (nucleolus spindle kinetochore 1) and the dynein light chain, Dlc1. The dimers form an oligomeric chain structure. Functions in the regulation of kinetochore-microtubule interactions and chromosome segregation." [GOC:vw, PMID:22065639]
is_a: GO:0043234 ! protein complex
created_by: janelomax
creation_date: 2013-10-21T14:38:16Z

[Term]
id: GO:0044817
name: hydrogen generation via biophotolysis
namespace: biological_process
def: "The production of hydrogen which results from the dissociation by light of water into molecular hydrogen and oxygen. This process is observed in cyanobacteria and microalgae." [GOC:mengo_curators, PMID:20395274, PMID:20692761]
synonym: "hydrogen biosynthesis via biophotolysis" EXACT []
is_a: GO:1902422 ! hydrogen biosynthetic process
created_by: janelomax
creation_date: 2013-10-22T14:36:54Z

[Term]
id: GO:0044818
name: mitotic G2/M transition checkpoint
namespace: biological_process
def: "A cell cycle checkpoint that detects and negatively regulates progression from G2 to M phase as part of a mitotic cell cycle." [GOC:mtg_cell_cycle]
is_a: GO:0007093 ! mitotic cell cycle checkpoint
is_a: GO:0010972 ! negative regulation of G2/M transition of mitotic cell cycle
created_by: janelomax
creation_date: 2013-11-19T14:20:00Z

[Term]
id: GO:0044819
name: mitotic G1/S transition checkpoint
namespace: biological_process
def: "A cell cycle checkpoint that detects and negatively regulates progression from G1 to S phase as part of a mitotic cell cycle." [GOC:mtg_cell_cycle]
is_a: GO:0007093 ! mitotic cell cycle checkpoint
is_a: GO:2000134 ! negative regulation of G1/S transition of mitotic cell cycle
created_by: janelomax
creation_date: 2013-11-19T14:31:14Z

[Term]
id: GO:0044820
name: mitotic telomere tethering at nuclear periphery
namespace: biological_process
def: "The process in which a telomere is maintained in a specific location at the nuclear periphery, as part of a mitotic cell cycle." [GOC:mtg_cell_cycle]
is_a: GO:0034398 ! telomere tethering at nuclear periphery
created_by: janelomax
creation_date: 2013-11-19T16:16:22Z

[Term]
id: GO:0044821
name: meiotic telomere tethering at nuclear periphery
namespace: biological_process
def: "The process in which a telomere is maintained in a specific location at the nuclear periphery, as part of a meiotic cell cycle." [GOC:mtg_cell_cycle]
is_a: GO:0034398 ! telomere tethering at nuclear periphery
is_a: GO:0045141 ! meiotic telomere clustering
created_by: janelomax
creation_date: 2013-11-19T16:18:09Z

[Term]
id: GO:0044822
name: poly(A) RNA binding
namespace: molecular_function
def: "Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases." [GOC:jl]
comment: Note that this term it to be used for the annotation of proteins that bind to any part of a polyadenylated RNA molecule, except the poly(A) tail. For annotation of proteins that specifically bind the poly(A) tail, use 'poly(A) binding ; GO:0008143'.
synonym: "poly(A)-RNA binding" EXACT []
synonym: "poly-A RNA binding" EXACT []
is_a: GO:0003723 ! RNA binding
created_by: janelomax
creation_date: 2014-01-30T14:50:22Z

[Term]
id: GO:0044823
name: retroviral integrase activity
namespace: molecular_function
def: "Catalysis of the covalent insertion of double-stranded retroviral DNA into host DNA. Proceeds by an endonucleolytic cleavage at each 3'-OH extremity of the viral genome, named 3'-processing, followed by a strand transfer reaction leading to the insertion of the processed viral DNA into the target DNA by a trans-esterification mechanism." [PMID:19091057]
is_a: GO:0008907 ! integrase activity
relationship: part_of GO:0044826 ! viral genome integration into host DNA
created_by: janelomax
creation_date: 2014-02-04T14:09:34Z

[Term]
id: GO:0044824
name: retroviral 3' processing activity
namespace: molecular_function
def: "The catalysis of the removal of two di- or tri-nucleotides from each 3' end of double-stranded viral DNA, exposing recessed 3' hydroxyls." [PMID:22580823, Reactome:REACT_9069.1]
comment: This reaction may serve to remove heterogenous extra bases from the viral DNA end, and to stabilize the integrase-DNA complex. The chemistry of cleavage is a simple hydrolysis by single-step transesterification.
synonym: "3' processing reaction" EXACT []
synonym: "3'-processing activity" EXACT []
xref: EC:3.1.-.-
xref: Reactome:REACT_9069.1
is_a: GO:0004520 ! endodeoxyribonuclease activity
relationship: part_of GO:0044823 ! retroviral integrase activity
created_by: janelomax
creation_date: 2014-02-04T14:51:24Z

[Term]
id: GO:0044825
name: retroviral strand transfer activity
namespace: molecular_function
def: "Catalysis of the covalent insertion of processed 3'-viral DNA ends into host chromosomal DNA by a trans-esterification reaction." [PMID:22580823]
synonym: "strand transfer reaction" EXACT []
is_a: GO:0003824 ! catalytic activity
relationship: part_of GO:0044823 ! retroviral integrase activity
created_by: janelomax
creation_date: 2014-02-04T15:16:39Z

[Term]
id: GO:0044826
name: viral genome integration into host DNA
namespace: biological_process
def: "The insertion into a host genome of viral DNA, usually by the action of an integrase enzyme. Once integrated, the provirus persists in the host cell and serves as a template for the transcription of viral genes and replication of the viral genome, leading to the production of new viruses." [PMID:19091057]
synonym: "viral genome integration" EXACT []
is_a: GO:0016032 ! viral process
relationship: part_of GO:0019058 ! viral life cycle
created_by: janelomax
creation_date: 2014-02-04T16:58:43Z

[Term]
id: GO:0044827
name: modulation by host of viral genome replication
namespace: biological_process
def: "A process in which a host organism modulates the frequency, rate or extent of viral genome replication." [GOC:jl]
synonym: "regulation by host of viral genome reproduction" EXACT []
is_a: GO:0044788 ! modulation by host of viral process
is_a: GO:0045069 ! regulation of viral genome replication
intersection_of: GO:0044788 ! modulation by host of viral process
intersection_of: regulates GO:0019079 ! viral genome replication
relationship: regulates GO:0019079 ! viral genome replication
created_by: janelomax
creation_date: 2014-02-06T11:26:45Z

[Term]
id: GO:0044828
name: negative regulation by host of viral genome replication
namespace: biological_process
def: "A process in which a host organism stops, prevents or reduces the frequency, rate or extent of viral genome replication." [GOC:jl]
is_a: GO:0019054 ! modulation by virus of host process
is_a: GO:0044793 ! negative regulation by host of viral process
is_a: GO:0044827 ! modulation by host of viral genome replication
is_a: GO:0045071 ! negative regulation of viral genome replication
intersection_of: GO:0019054 ! modulation by virus of host process
intersection_of: negatively_regulates GO:0019079 ! viral genome replication
relationship: negatively_regulates GO:0019079 ! viral genome replication
created_by: janelomax
creation_date: 2014-02-06T11:34:23Z

[Term]
id: GO:0044829
name: positive regulation by host of viral genome replication
namespace: biological_process
def: "A process in which a host organism activates or increases the frequency, rate or extent of  viral genome replication." [GOC:jl]
is_a: GO:0044794 ! positive regulation by host of viral process
is_a: GO:0044827 ! modulation by host of viral genome replication
is_a: GO:0045070 ! positive regulation of viral genome replication
intersection_of: GO:0044788 ! modulation by host of viral process
intersection_of: positively_regulates GO:0019079 ! viral genome replication
relationship: positively_regulates GO:0019079 ! viral genome replication
created_by: janelomax
creation_date: 2014-02-06T11:35:07Z

[Term]
id: GO:0044830
name: modulation by host of viral RNA genome replication
namespace: biological_process
def: "A process in which a host organism modulates the frequency, rate or extent of viral RNA genome replication." [GOC:jl]
synonym: "regulation by host of viral RNA genome replication" EXACT []
is_a: GO:0044827 ! modulation by host of viral genome replication
is_a: GO:0051252 ! regulation of RNA metabolic process
intersection_of: GO:0044788 ! modulation by host of viral process
intersection_of: regulates GO:0039694 ! viral RNA genome replication
relationship: regulates GO:0039694 ! viral RNA genome replication
created_by: janelomax
creation_date: 2014-02-06T11:43:16Z

[Term]
id: GO:0044831
name: modulation by virus of host cytokine production
namespace: biological_process
def: "Any process in which a virus modulates the frequency, rate or extent of cytokine production in its host organism." [GOC:jl]
is_a: GO:0001817 ! regulation of cytokine production
is_a: GO:0075528 ! modulation by virus of host immune response
intersection_of: GO:0075528 ! modulation by virus of host immune response
intersection_of: regulates GO:0001816 ! cytokine production
relationship: regulates GO:0001816 ! cytokine production
created_by: janelomax
creation_date: 2014-02-06T12:49:02Z

[Term]
id: GO:0044832
name: positive regulation by virus of host cytokine production
namespace: biological_process
def: "The process in which a virus increases the frequency, rate or extent of cytokine production in its host organism." [GOC:jl]
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0044831 ! modulation by virus of host cytokine production
intersection_of: GO:0075528 ! modulation by virus of host immune response
intersection_of: positively_regulates GO:0001816 ! cytokine production
relationship: positively_regulates GO:0001816 ! cytokine production
created_by: janelomax
creation_date: 2014-02-06T13:04:23Z

[Term]
id: GO:0044833
name: modulation by virus of host protein transport
namespace: biological_process
def: "Any viral process that modulates the frequency, rate or extent of protein transport in its host organism." [GOC:jl, PMID:22334672]
is_a: GO:0019054 ! modulation by virus of host process
is_a: GO:0051223 ! regulation of protein transport
is_a: GO:0052038 ! modulation by symbiont of host intracellular transport
intersection_of: GO:0019054 ! modulation by virus of host process
intersection_of: regulates GO:0015031 ! protein transport
relationship: regulates GO:0015031 ! protein transport
created_by: janelomax
creation_date: 2014-02-06T13:25:52Z

[Term]
id: GO:0044834
name: retroviral intasome
namespace: cellular_component
def: "A tetramer of retroviral integrase subunits tightly associated with a pair of viral DNA ends. Functions to insert viral DNA into a host cell chromosome." [PMID:20118915]
subset: virus_checked
is_a: GO:0032993 ! protein-DNA complex
created_by: janelomax
creation_date: 2014-02-06T14:33:39Z

[Term]
id: GO:0044835
name: hydrogen generation via nitrogenase
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of H2 (dihydrogen) which involve a nitrogenase activity as one of the steps. This process is observed in cyanobacteria." [GOC:mengo_curators, PMID:22128188]
is_a: GO:1902422 ! hydrogen biosynthetic process
intersection_of: GO:1902422 ! hydrogen biosynthetic process
intersection_of: has_part GO:0016163 ! nitrogenase activity
relationship: has_part GO:0016163 ! nitrogenase activity
created_by: janelomax
creation_date: 2014-02-19T14:59:15Z

[Term]
id: GO:0044836
name: D-xylose fermentation
namespace: biological_process
def: "The anaerobic enzymatic conversion of D-xylose to ethanol, yielding energy in the form of ATP." [GOC:mengo_curators]
is_a: GO:0006113 ! fermentation
is_a: GO:0044577 ! xylose catabolic process to ethanol
created_by: janelomax
creation_date: 2014-02-19T16:14:57Z

[Term]
id: GO:0044837
name: actomyosin contractile ring organization
namespace: biological_process
def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of an actomyosin contractile ring." [GOC:mtg_cell_cycle]
synonym: "cytokinesis, actomyosin contractile ring organization" EXACT []
is_a: GO:0030866 ! cortical actin cytoskeleton organization
is_a: GO:0031032 ! actomyosin structure organization
created_by: janelomax
creation_date: 2014-02-26T15:31:31Z

[Term]
id: GO:0044838
name: cell quiescence
namespace: biological_process
def: "A specialized resting state that cells enter in response to cues from the cell's environment. Quiescence is characterized by the absence of cell growth and division, by a reprogramming of global gene expression, and by changes characteristic of the organism and specific cell type. Depending on external conditions, quiescence may persist until cell death or cells may resume cell growth and division. In some cell types or under certain conditions, cellular metabolism may proceed." [GOC:jb, GOC:mah]
comment: Note that terminally differentiated cells in higher eukaryotes are typically quiescent but metabolically active. Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "cell cycle quiescence" RELATED [GOC:mah]
synonym: "cellular quiescence" EXACT [GOC:mah]
synonym: "G0 phase" RELATED [GOC:mah]
synonym: "quiescence" BROAD [GOC:mah]
is_a: GO:0022403 ! cell cycle phase
created_by: janelomax
creation_date: 2014-02-26T16:15:51Z

[Term]
id: GO:0044839
name: cell cycle G2/M phase transition
namespace: biological_process
def: "The cell cycle process by which a cell in G2 phase commits to M phase." [GOC:jl, GOC:mtg_cell_cycle]
is_a: GO:0044770 ! cell cycle phase transition
created_by: janelomax
creation_date: 2014-03-05T14:56:45Z

[Term]
id: GO:0044840
name: gut granule
namespace: cellular_component
def: "A lysosome-related organelle contained within the intestinal cells of the nematode C. elegans. Gut granules are acidified, birefringent, autofluorescent, and contain the vacuolar H+-ATPase. They also serve as sites of cellular zinc storage." [GOC:kmv, PMID:22916203, PMID:24204312]
is_a: GO:0016023 ! cytoplasmic, membrane-bounded vesicle
created_by: janelomax
creation_date: 2014-03-25T11:56:41Z

[Term]
id: GO:0044841
name: gut granule membrane
namespace: cellular_component
def: "The lumen of a gut granule, a lysosome-related organelle contained within the intestinal cells of the nematode C. elegans." [GOC:kmv, PMID:22916203, PMID:24204312]
is_a: GO:0031090 ! organelle membrane
is_a: GO:0044433 ! cytoplasmic vesicle part
intersection_of: GO:0031090 ! organelle membrane
intersection_of: part_of GO:0044840 ! gut granule
relationship: part_of GO:0044840 ! gut granule
created_by: janelomax
creation_date: 2014-03-25T12:02:05Z

[Term]
id: GO:0044842
name: gut granule lumen
namespace: cellular_component
def: "The lumen of a gut granule, a lysosome-related organelle contained within the intestinal cells of the nematode C. elegans." [GOC:kmv, PMID:22916203, PMID:24204312]
is_a: GO:0043233 ! organelle lumen
is_a: GO:0044433 ! cytoplasmic vesicle part
intersection_of: GO:0043233 ! organelle lumen
intersection_of: part_of GO:0044840 ! gut granule
relationship: part_of GO:0044840 ! gut granule
created_by: janelomax
creation_date: 2014-03-25T12:02:32Z

[Term]
id: GO:0044843
name: cell cycle G1/S phase transition
namespace: biological_process
def: "The cell cycle process by which a cell in G1 phase commits to S phase." [GOC:mtg_cell_cycle]
is_a: GO:0044770 ! cell cycle phase transition
created_by: janelomax
creation_date: 2014-03-25T16:33:47Z

[Term]
id: GO:0044844
name: meiotic interphase II
namespace: biological_process
def: "The cell cycle phase which begins at the end of meiosis I cytokinesis and ends when meiosis II prophase begins. During meiotic interphase II no DNA replication takes place, but the centrioles duplicate and spindle fibres emerge." [GOC:jl, GOC:mtg_cell_cycle]
comment: note that this term should not be used for direct annotation. if you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic s-phase). to capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0051328 ! meiotic interphase
is_a: GO:0098765 ! meiosis II cell cycle phase
created_by: janelomax
creation_date: 2014-03-26T16:52:27Z

[Term]
id: GO:0044845
name: chain elongation of O-linked mannose residue
namespace: biological_process
def: "Extension of the O-linked mannose residue of a mannoprotein by the stepwise addition of further mannose molecules." [GOC:jl, PMID:19429925]
comment: Example annotations to this term include the S. cerevisiae alpha1,2-mannosyltransferases ScKre2p, ScKtr1p and ScKtr3pof the KTR family.
is_a: GO:0035268 ! protein mannosylation
created_by: janelomax
creation_date: 2014-05-08T15:56:39Z

[Term]
id: GO:0044846
name: negative regulation by symbiont of indole acetic acid levels in host
namespace: biological_process
def: "Any process in which an organism reduces the indole acetic acid levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:ml, PMID:18056646]
synonym: "negative regulation by symbiont of auxin levels in host" EXACT []
synonym: "negative regulation by symbiont of IAA levels in host" EXACT []
is_a: GO:0044032 ! modulation by symbiont of indole acetic acid levels in host
created_by: janelomax
creation_date: 2014-05-13T11:08:04Z

[Term]
id: GO:0044847
name: iron acquisition by symbiont from host
namespace: biological_process
def: "The process by which a symbiont acquires iron from its host, either from heme or other iron containing molecules such as transferrin and lactoferrin. Begins with either the secretion of symbiont gene products that bind iron- or heme-containing molecules (siderophores and hemophores) from the symbiont cell into the host, or by expression of receptors that bind iron- or heme-containing molecules on the symbiont cell surface. Ends when the iron-containing compound is transported into the symbiont cell." [PMID:15487950, PMID:22865843]
comment: Note that this process can be independent of siderophores. We may at some point want to make a child term 'iron acquisition by symbiont from host via siderophore' which could also be a child of 'acquisition by symbiont of nutrients from host via siderophores'.
synonym: "heme acquisition" NARROW []
synonym: "iron acquisition" NARROW []
synonym: "iron acquisition by symbiont from host heme" BROAD []
is_a: GO:0044002 ! acquisition of nutrients from host
created_by: janelomax
creation_date: 2014-05-13T13:40:59Z

[Term]
id: GO:0044848
name: biological phase
namespace: biological_process
def: "A distinct period or stage in a biological process or cycle." [GOC:jl]
comment: Note that phases are is_a disjoint from other biological processes. happens_during relationships can operate between phases and other biological processes e.g. DNA replication happens_during S phase.
subset: gocheck_do_not_manually_annotate
is_a: GO:0008150 ! biological_process
disjoint_from: GO:0046879 ! hormone secretion
disjoint_from: GO:0048511 ! rhythmic process
disjoint_from: GO:0050896 ! response to stimulus
disjoint_from: GO:0051179 ! localization
disjoint_from: GO:0051704 ! multi-organism process
disjoint_from: GO:0071840 ! cellular component organization or biogenesis
disjoint_from: GO:0098743 ! cell aggregation
created_by: janelomax
creation_date: 2014-07-16T13:12:40Z

[Term]
id: GO:0044849
name: estrous cycle
namespace: biological_process
def: "A type of ovulation cycle, which occurs in most mammalian therian females, where the endometrium is resorbed if pregnancy does not occur." [GOC:jl, Wikipedia:Estrous_cycle]
xref: Wikipedia:Estrous_cycle
is_a: GO:0042698 ! ovulation cycle
created_by: janelomax
creation_date: 2014-07-16T13:41:42Z

[Term]
id: GO:0044850
name: menstrual cycle
namespace: biological_process
def: "A type of ovulation cycle where the endometrium is shed if pregnancy does not occur." [GOC:jl]
xref: Wikipedia:Menstrual_cycle
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0042698 ! ovulation cycle
is_a: GO:0044767 ! single-organism developmental process
created_by: janelomax
creation_date: 2014-07-16T13:51:29Z

[Term]
id: GO:0044851
name: hair cycle phase
namespace: biological_process
def: "The cyclical periods of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body." [GOC:jl]
subset: gocheck_do_not_annotate
is_a: GO:0044848 ! biological phase
created_by: janelomax
creation_date: 2014-07-16T14:22:09Z

[Term]
id: GO:0044852
name: nonrepetitive DNA condensation
namespace: biological_process
def: "The process in which chromatin structure of nonrepetitive regions of DNA is compacted prior to and during mitosis in eukaryotic cells." [GOC:jl, PMID:10811823]
synonym: "nonrepetitive DNA packaging" EXACT []
is_a: GO:0006323 ! DNA packaging
relationship: part_of GO:0030261 ! chromosome condensation
created_by: janelomax
creation_date: 2014-07-17T14:13:23Z

[Term]
id: GO:0044853
name: plasma membrane raft
namespace: cellular_component
def: "A membrane raft that is part of the plasma membrane." [GOC:jl]
is_a: GO:0045121 ! membrane raft
is_a: GO:0098590 ! plasma membrane region
intersection_of: GO:0045121 ! membrane raft
intersection_of: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0005886 ! plasma membrane
created_by: janelomax
creation_date: 2014-07-23T15:55:23Z

[Term]
id: GO:0044854
name: plasma membrane raft assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a plasma membrane raft." [GOC:jl]
is_a: GO:0001765 ! membrane raft assembly
is_a: GO:0044857 ! plasma membrane raft organization
created_by: janelomax
creation_date: 2014-07-23T15:58:16Z

[Term]
id: GO:0044855
name: plasma membrane raft distribution
namespace: biological_process
def: "The process that establishes the spatial arrangement of membrane rafts within a plasma membrane." [GOC:jl]
is_a: GO:0031580 ! membrane raft distribution
is_a: GO:0044856 ! plasma membrane raft localization
created_by: janelomax
creation_date: 2014-07-23T16:00:41Z

[Term]
id: GO:0044856
name: plasma membrane raft localization
namespace: biological_process
def: "Any process in which plasma membrane rafts are transported to, or maintained in, a specific location." [GOC:jl]
is_a: GO:0051665 ! membrane raft localization
created_by: janelomax
creation_date: 2014-07-23T16:12:22Z

[Term]
id: GO:0044857
name: plasma membrane raft organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of plasma membrane rafts." [GOC:jl]
is_a: GO:0031579 ! membrane raft organization
relationship: part_of GO:0007009 ! plasma membrane organization
created_by: janelomax
creation_date: 2014-07-23T16:20:07Z

[Term]
id: GO:0044858
name: plasma membrane raft polarization
namespace: biological_process
def: "The clustering and aggregation of plasma membrane rafts at a single cellular pole during activation of particular cell types, such as lymphocytes." [GOC:jl]
is_a: GO:0001766 ! membrane raft polarization
is_a: GO:0044855 ! plasma membrane raft distribution
created_by: janelomax
creation_date: 2014-07-23T16:21:39Z

[Term]
id: GO:0044859
name: protein insertion into plasma membrane raft
namespace: biological_process
def: "The process in which a protein is incorporated into a plasma membrane raft." [GOC:jl]
is_a: GO:0071210 ! protein insertion into membrane raft
is_a: GO:0098737 ! protein insertion into plasma membrane
created_by: janelomax
creation_date: 2014-07-23T16:23:20Z

[Term]
id: GO:0044860
name: protein localization to plasma membrane raft
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a plasma membrane raft." [GOC:jl]
is_a: GO:0072659 ! protein localization to plasma membrane
is_a: GO:1903044 ! protein localization to membrane raft
created_by: janelomax
creation_date: 2014-07-23T16:25:01Z

[Term]
id: GO:0044861
name: protein transport into plasma membrane raft
namespace: biological_process
def: "The directed movement of a protein into a plasma membrane raft." [GOC:jl]
is_a: GO:0032596 ! protein transport into membrane raft
is_a: GO:0044860 ! protein localization to plasma membrane raft
is_a: GO:0090002 ! establishment of protein localization to plasma membrane
created_by: janelomax
creation_date: 2014-07-23T16:26:29Z

[Term]
id: GO:0044862
name: protein transport out of plasma membrane raft
namespace: biological_process
def: "The directed movement of a protein out of a plasma membrane raft." [GOC:jl]
is_a: GO:0032599 ! protein transport out of membrane raft
is_a: GO:0099632 ! protein transport within plasma membrane
relationship: occurs_in GO:0005886 ! plasma membrane
created_by: janelomax
creation_date: 2014-07-23T16:32:56Z

[Term]
id: GO:0044863
name: modulation by virus of host cell division
namespace: biological_process
def: "Any process where an infecting virus modulates the frequency, rate or extent of the physical partitioning and separation of its host's cell into daughter cells." [GOC:jl]
synonym: "regulation by virus of host cell division" EXACT []
is_a: GO:0019054 ! modulation by virus of host process
is_a: GO:0051302 ! regulation of cell division
created_by: janelomax
creation_date: 2014-08-05T16:30:03Z

[Term]
id: GO:0044864
name: positive regulation by virus of host cell division
namespace: biological_process
def: "Any process where an infecting virus activates or increases the frequency, rate or extent of its host's cell division." [GOC:jl]
is_a: GO:0044863 ! modulation by virus of host cell division
is_a: GO:0051781 ! positive regulation of cell division
created_by: janelomax
creation_date: 2014-08-05T16:31:20Z

[Term]
id: GO:0044865
name: negative regulation by virus of host cell division
namespace: biological_process
def: "Any process where an infecting virus stops, prevents, or reduces the frequency, rate or extent of its host's cell division." [GOC:jl]
synonym: "inhibition by virus of host cell division" NARROW []
is_a: GO:0044863 ! modulation by virus of host cell division
is_a: GO:0051782 ! negative regulation of cell division
created_by: janelomax
creation_date: 2014-08-05T16:31:44Z

[Term]
id: GO:0044866
name: modulation by host of viral exo-alpha-sialidase activity
namespace: biological_process
def: "The process in which an organism effects a change in symbiont exo-alpha-sialidase activity, the catalysis of the hydrolysis of peptide bonds in a protein." [GOC:jl]
is_a: GO:0044867 ! modulation by host of viral catalytic activity
is_a: GO:1903015 ! regulation of exo-alpha-sialidase activity
intersection_of: GO:0044867 ! modulation by host of viral catalytic activity
intersection_of: regulates GO:0004308 ! exo-alpha-sialidase activity
relationship: regulates GO:0004308 ! exo-alpha-sialidase activity
created_by: janelomax
creation_date: 2014-09-18T11:28:18Z

[Term]
id: GO:0044867
name: modulation by host of viral catalytic activity
namespace: biological_process
def: "The process in which a host organism effects a change in the enzyme activity of a virus with which it is infected." [GOC:jl]
is_a: GO:0044868 ! modulation by host of viral molecular function
is_a: GO:0052422 ! modulation by host of symbiont catalytic activity
intersection_of: GO:0044868 ! modulation by host of viral molecular function
intersection_of: regulates GO:0003824 ! catalytic activity
relationship: regulates GO:0003824 ! catalytic activity
created_by: janelomax
creation_date: 2014-09-18T11:29:25Z

[Term]
id: GO:0044868
name: modulation by host of viral molecular function
namespace: biological_process
def: "A process in which a host organism modulates the frequency, rate or extent of any molecular function being mediated by a virus with which it is infected." [GOC:jl]
is_a: GO:0044788 ! modulation by host of viral process
created_by: janelomax
creation_date: 2014-09-18T13:34:27Z

[Term]
id: GO:0044869
name: negative regulation by host of viral exo-alpha-sialidase activity
namespace: biological_process
def: "The process in which an organism effects a change in symbiont exo-alpha-sialidase activity, the catalysis of the hydrolysis of peptide bonds in a protein." [GOC:jl]
is_a: GO:0044866 ! modulation by host of viral exo-alpha-sialidase activity
is_a: GO:0052403 ! negative regulation by host of symbiont catalytic activity
is_a: GO:1903016 ! negative regulation of exo-alpha-sialidase activity
intersection_of: GO:0044868 ! modulation by host of viral molecular function
intersection_of: negatively_regulates GO:0004308 ! exo-alpha-sialidase activity
relationship: negatively_regulates GO:0004308 ! exo-alpha-sialidase activity
created_by: janelomax
creation_date: 2014-09-18T14:13:51Z

[Term]
id: GO:0044870
name: modulation by host of viral glycoprotein metabolic process
namespace: biological_process
def: "A process in which a host organism modulates the frequency, rate or extent of viral glycoprotein metabolic process." [GOC:jl]
is_a: GO:0044788 ! modulation by host of viral process
is_a: GO:1903018 ! regulation of glycoprotein metabolic process
intersection_of: GO:0044788 ! modulation by host of viral process
intersection_of: regulates GO:0009100 ! glycoprotein metabolic process
relationship: regulates GO:0009100 ! glycoprotein metabolic process
created_by: janelomax
creation_date: 2014-09-18T14:26:19Z

[Term]
id: GO:0044871
name: negative regulation by host of viral glycoprotein metabolic process
namespace: biological_process
def: "A process in which a host organism stops, prevents or reduces the frequency, rate or extent of viral glycoprotein metabolic process." [GOC:jl]
is_a: GO:0044793 ! negative regulation by host of viral process
is_a: GO:0044870 ! modulation by host of viral glycoprotein metabolic process
is_a: GO:1903019 ! negative regulation of glycoprotein metabolic process
intersection_of: GO:0048525 ! negative regulation of viral process
intersection_of: negatively_regulates GO:0009100 ! glycoprotein metabolic process
relationship: negatively_regulates GO:0009100 ! glycoprotein metabolic process
created_by: janelomax
creation_date: 2014-09-18T14:28:48Z

[Term]
id: GO:0044872
name: lipoprotein localization
namespace: biological_process
def: "Any process in which a lipoprotein is transported to, or maintained in, a specific location." [GOC:jl]
is_a: GO:0008104 ! protein localization
created_by: janelomax
creation_date: 2014-11-25T16:27:06Z

[Term]
id: GO:0044873
name: lipoprotein localization to membrane
namespace: biological_process
def: "A process in which a lipoprotein is transported to, or maintained in, a specific location in a membrane." [GOC:jl]
is_a: GO:0044872 ! lipoprotein localization
is_a: GO:0072657 ! protein localization to membrane
created_by: janelomax
creation_date: 2014-11-25T16:28:43Z

[Term]
id: GO:0044874
name: lipoprotein localization to outer membrane
namespace: biological_process
def: "A process in which a lipoprotein is transported to, or maintained in, a specific location in an outer membrane." [GOC:jl]
is_a: GO:0044873 ! lipoprotein localization to membrane
created_by: janelomax
creation_date: 2014-11-25T16:30:30Z

[Term]
id: GO:0044875
name: gamma-glutamyl hercynylcysteine sulfoxide synthase
namespace: molecular_function
def: "Catalysis of the reaction: gamma-glutamyl cysteine + hercynine + O2 <=> gamma-glutamyl-hercynyl cysteine sulfoxide + H2O." [GOC:jl, PMID:24828577]
synonym: "gamma-glutamyl hercynylcysteine S-oxide synthase" EXACT [GOC:dph]
xref: EC:1.14.99.-
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
created_by: janelomax
creation_date: 2014-12-15T11:44:54Z

[Term]
id: GO:0044876
name: hercynylselenocysteine synthase
namespace: molecular_function
def: "Catalysis of the reaction: 2 L-selenocysteine + 2 hercynine + O2 <=> 2 H2O + 2 hercynylselenocysteine." [GOC:jl, PMID:24828577]
xref: MetaCyc:RXN-15803
xref: RHEA:42683
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
created_by: janelomax
creation_date: 2014-12-15T11:56:12Z

[Term]
id: GO:0044877
name: macromolecular complex binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any macromolecular complex." [GOC:jl]
is_a: GO:0005488 ! binding
created_by: janelomax
creation_date: 2014-12-16T11:38:58Z

[Term]
id: GO:0044878
name: mitotic cytokinesis checkpoint
namespace: biological_process
def: "A mitotic cell cycle checkpoint that detects a defect in cytokinesis and negatively regulates mitosis in the following cell cycle." [GOC:jl, GOC:mtg_cell_cycle]
comment: These cells display defects in cytokinetic ring formation and fail to assemble a septum, but nevertheless enter a new cell cycle, go through one round of DNA replication, and then arrest in G2 of the following cell cycle.
synonym: "cytokinesis after mitosis checkpoint" RELATED [GOC:dph, GOC:vw]
synonym: "defective cytokinesis checkpoint" RELATED [GOC:dph, GOC:vw]
is_a: GO:0007093 ! mitotic cell cycle checkpoint
created_by: janelomax
creation_date: 2015-01-13T15:30:23Z

[Term]
id: GO:0044879
name: morphogenesis checkpoint
namespace: biological_process
def: "A mitotic cell cycle checkpoint which delays mitotic onset in response to perturbations that affect cell shape via the actin cytoskeleton, septin organization, small cell size, and/or the extent of membrane growth." [GOC:jl, GOC:mtg_cell_cycle]
synonym: "septin checkpoint" EXACT []
is_a: GO:0007093 ! mitotic cell cycle checkpoint
created_by: janelomax
creation_date: 2015-01-13T16:03:07Z

[Term]
id: GO:0045002
name: double-strand break repair via single-strand annealing
namespace: biological_process
def: "Repair of a DSB made between two repeated sequences oriented in the same direction occurs primarily by the single strand annealing pathway. The ends of the break are processed by a 5' to 3' exonuclease, exposing complementary single-strand regions of the direct repeats that can anneal, resulting in a deletion of the unique DNA between the direct repeats." [PMID:11606529]
subset: gosubset_prok
is_a: GO:0000726 ! non-recombinational repair
is_a: GO:0006302 ! double-strand break repair

[Term]
id: GO:0045003
name: double-strand break repair via synthesis-dependent strand annealing
namespace: biological_process
def: "SDSA is a major mechanism of double-strand break repair in mitosis which allows for the error-free repair of a double-strand break without the exchange of adjacent sequences. The broken DNA searches for and base pairs with a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template. Newly synthesized DNA is then displaced from the template and anneal with its complement on the other side of the double-strand break." [PMID:10357855]
subset: gosubset_prok
synonym: "mitotic gene conversion" RELATED []
synonym: "SDSA" BROAD []
xref: Reactome:REACT_684 "Resolution of D-loop structures through synthesis-dependent strand-annealing, Homo sapiens"
is_a: GO:0000724 ! double-strand break repair via homologous recombination

[Term]
id: GO:0045004
name: DNA replication proofreading
namespace: biological_process
def: "Correction of replication errors by DNA polymerase using a 3'-5' exonuclease activity." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006281 ! DNA repair
is_a: GO:0045005 ! DNA-dependent DNA replication maintenance of fidelity

[Term]
id: GO:0045005
name: DNA-dependent DNA replication maintenance of fidelity
namespace: biological_process
def: "A DNA metabolic process that prevents or corrects errors to ensure that DNA is replicated accurately. Errors can be corrected either by intrinsic DNA polymerase proofreading activity or via mismatch repair." [GOC:mah, GOC:vw]
subset: gosubset_prok
synonym: "maintenance of fidelity during DNA-dependent DNA replication" RELATED [GOC:dph, GOC:tb]
synonym: "maintenance of fidelity involved in DNA-dependent DNA replication" EXACT []
is_a: GO:0006259 ! DNA metabolic process
relationship: part_of GO:0006261 ! DNA-dependent DNA replication

[Term]
id: GO:0045006
name: DNA deamination
namespace: biological_process
def: "The removal of an amino group from a nucleotide base in DNA. An example is the deamination of cytosine to produce uracil." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006304 ! DNA modification

[Term]
id: GO:0045007
name: depurination
namespace: biological_process
def: "The disruption of the bond between the sugar in the backbone and the A or G base, causing the base to be removed and leaving a depurinated sugar." [GOC:ai]
subset: gosubset_prok
xref: Reactome:REACT_101068 "Cleavage of the damaged purine, Gallus gallus"
xref: Reactome:REACT_101209 "Cleavage of the damaged purine, Schizosaccharomyces pombe"
xref: Reactome:REACT_102094 "Recognition and association of DNA glycosylase with site containing an affected purine, Xenopus tropicalis"
xref: Reactome:REACT_102414 "Depurination, Drosophila melanogaster"
xref: Reactome:REACT_102471 "Cleavage of the damaged purine, Arabidopsis thaliana"
xref: Reactome:REACT_102608 "Depurination, Plasmodium falciparum"
xref: Reactome:REACT_102879 "Depurination, Escherichia coli"
xref: Reactome:REACT_103774 "Recognition and association of DNA glycosylase with site containing an affected purine, Arabidopsis thaliana"
xref: Reactome:REACT_104029 "Recognition and association of DNA glycosylase with site containing an affected purine, Escherichia coli"
xref: Reactome:REACT_105327 "Depurination, Dictyostelium discoideum"
xref: Reactome:REACT_105369 "Depurination, Mycobacterium tuberculosis"
xref: Reactome:REACT_105436 "Recognition and association of DNA glycosylase with site containing an affected purine, Mus musculus"
xref: Reactome:REACT_106082 "Cleavage of the damaged purine, Mycobacterium tuberculosis"
xref: Reactome:REACT_108069 "Recognition and association of DNA glycosylase with site containing an affected purine, Saccharomyces cerevisiae"
xref: Reactome:REACT_108230 "Depurination, Saccharomyces cerevisiae"
xref: Reactome:REACT_108479 "Cleavage of the damaged purine, Rattus norvegicus"
xref: Reactome:REACT_109355 "Depurination, Sus scrofa"
xref: Reactome:REACT_109978 "Recognition and association of DNA glycosylase with site containing an affected purine, Mycobacterium tuberculosis"
xref: Reactome:REACT_1729 "Cleavage of the damaged purine, Homo sapiens"
xref: Reactome:REACT_2176 "Recognition and association of DNA glycosylase with site containing an affected purine, Homo sapiens"
xref: Reactome:REACT_28084 "Cleavage of the damaged purine, Xenopus tropicalis"
xref: Reactome:REACT_29282 "Recognition and association of DNA glycosylase with site containing an affected purine, Danio rerio"
xref: Reactome:REACT_30239 "Depurination, Gallus gallus"
xref: Reactome:REACT_31199 "Depurination, Mus musculus"
xref: Reactome:REACT_32465 "Cleavage of the damaged purine, Drosophila melanogaster"
xref: Reactome:REACT_33494 "Recognition and association of DNA glycosylase with site containing an affected purine, Plasmodium falciparum"
xref: Reactome:REACT_33961 "Recognition and association of DNA glycosylase with site containing an affected purine, Drosophila melanogaster"
xref: Reactome:REACT_34478 "Cleavage of the damaged purine, Saccharomyces cerevisiae"
xref: Reactome:REACT_626 "Depurination, Homo sapiens"
xref: Reactome:REACT_78504 "Depurination, Staphylococcus aureus N315"
xref: Reactome:REACT_78746 "Recognition and association of DNA glycosylase with site containing an affected purine, Gallus gallus"
xref: Reactome:REACT_78887 "Cleavage of the damaged purine, Staphylococcus aureus N315"
xref: Reactome:REACT_80398 "Depurination, Xenopus tropicalis"
xref: Reactome:REACT_80481 "Recognition and association of DNA glycosylase with site containing an affected purine, Sus scrofa"
xref: Reactome:REACT_81433 "Depurination, Taeniopygia guttata"
xref: Reactome:REACT_81740 "Cleavage of the damaged purine, Sus scrofa"
xref: Reactome:REACT_83025 "Cleavage of the damaged purine, Escherichia coli"
xref: Reactome:REACT_83092 "Recognition and association of DNA glycosylase with site containing an affected purine, Canis familiaris"
xref: Reactome:REACT_83710 "Depurination, Schizosaccharomyces pombe"
xref: Reactome:REACT_84733 "Depurination, Canis familiaris"
xref: Reactome:REACT_85805 "Cleavage of the damaged purine, Mus musculus"
xref: Reactome:REACT_88079 "Recognition and association of DNA glycosylase with site containing an affected purine, Oryza sativa"
xref: Reactome:REACT_88470 "Depurination, Arabidopsis thaliana"
xref: Reactome:REACT_89863 "Recognition and association of DNA glycosylase with site containing an affected purine, Dictyostelium discoideum"
xref: Reactome:REACT_90682 "Cleavage of the damaged purine, Canis familiaris"
xref: Reactome:REACT_92012 "Cleavage of the damaged purine, Dictyostelium discoideum"
xref: Reactome:REACT_92966 "Cleavage of the damaged purine, Taeniopygia guttata"
xref: Reactome:REACT_93169 "Cleavage of the damaged purine, Oryza sativa"
xref: Reactome:REACT_93334 "Depurination, Danio rerio"
xref: Reactome:REACT_93812 "Recognition and association of DNA glycosylase with site containing an affected purine, Bos taurus"
xref: Reactome:REACT_93813 "Cleavage of the damaged purine, Danio rerio"
xref: Reactome:REACT_94059 "Cleavage of the damaged purine, Plasmodium falciparum"
xref: Reactome:REACT_94889 "Depurination, Bos taurus"
xref: Reactome:REACT_95544 "Recognition and association of DNA glycosylase with site containing an affected purine, Rattus norvegicus"
xref: Reactome:REACT_95906 "Recognition and association of DNA glycosylase with site containing an affected purine, Staphylococcus aureus N315"
xref: Reactome:REACT_99146 "Depurination, Rattus norvegicus"
xref: Reactome:REACT_99544 "Cleavage of the damaged purine, Bos taurus"
xref: Reactome:REACT_99909 "Recognition and association of DNA glycosylase with site containing an affected purine, Taeniopygia guttata"
xref: Reactome:REACT_99931 "Depurination, Oryza sativa"
xref: Reactome:REACT_99935 "Recognition and association of DNA glycosylase with site containing an affected purine, Schizosaccharomyces pombe"
xref: Wikipedia:Depurination
is_a: GO:0006285 ! base-excision repair, AP site formation
is_a: GO:0006304 ! DNA modification
is_a: GO:0009155 ! purine deoxyribonucleotide catabolic process

[Term]
id: GO:0045008
name: depyrimidination
namespace: biological_process
def: "The disruption of the bond between the sugar in the backbone and the C or T base, causing the base to be removed and leaving a depyrimidinated sugar." [GOC:ai]
subset: gosubset_prok
xref: Reactome:REACT_100256 "Depyrimidination, Rattus norvegicus"
xref: Reactome:REACT_100789 "Depyrimidination, Xenopus tropicalis"
xref: Reactome:REACT_102247 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine, Drosophila melanogaster"
xref: Reactome:REACT_102696 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine, Xenopus tropicalis"
xref: Reactome:REACT_104941 "Depyrimidination, Mus musculus"
xref: Reactome:REACT_105235 "Cleavage of the damaged pyrimidine, Staphylococcus aureus N315"
xref: Reactome:REACT_106823 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine, Sus scrofa"
xref: Reactome:REACT_107196 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine, Taeniopygia guttata"
xref: Reactome:REACT_108611 "Cleavage of the damaged pyrimidine, Mycobacterium tuberculosis"
xref: Reactome:REACT_108815 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine, Bos taurus"
xref: Reactome:REACT_110913 "Cleavage of the damaged pyrimidine, Escherichia coli"
xref: Reactome:REACT_115575 "Depyrimidination, Gallus gallus"
xref: Reactome:REACT_1405 "Depyrimidination, Homo sapiens"
xref: Reactome:REACT_2156 "Cleavage of the damaged pyrimidine, Homo sapiens"
xref: Reactome:REACT_28306 "Depyrimidination, Mycobacterium tuberculosis"
xref: Reactome:REACT_28345 "Depyrimidination, Plasmodium falciparum"
xref: Reactome:REACT_28725 "Depyrimidination, Schizosaccharomyces pombe"
xref: Reactome:REACT_30620 "Cleavage of the damaged pyrimidine, Mus musculus"
xref: Reactome:REACT_30824 "Cleavage of the damaged pyrimidine, Oryza sativa"
xref: Reactome:REACT_32071 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine, Mycobacterium tuberculosis"
xref: Reactome:REACT_33648 "Depyrimidination, Staphylococcus aureus N315"
xref: Reactome:REACT_702 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine, Homo sapiens"
xref: Reactome:REACT_76967 "Cleavage of the damaged pyrimidine, Arabidopsis thaliana"
xref: Reactome:REACT_77984 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine, Arabidopsis thaliana"
xref: Reactome:REACT_78175 "Depyrimidination, Oryza sativa"
xref: Reactome:REACT_78723 "Depyrimidination, Taeniopygia guttata"
xref: Reactome:REACT_78848 "Depyrimidination, Caenorhabditis elegans"
xref: Reactome:REACT_78930 "Cleavage of the damaged pyrimidine, Plasmodium falciparum"
xref: Reactome:REACT_79381 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine, Mus musculus"
xref: Reactome:REACT_79463 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine, Oryza sativa"
xref: Reactome:REACT_79828 "Cleavage of the damaged pyrimidine, Taeniopygia guttata"
xref: Reactome:REACT_80782 "Cleavage of the damaged pyrimidine, Danio rerio"
xref: Reactome:REACT_81261 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine, Escherichia coli"
xref: Reactome:REACT_81890 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine, Saccharomyces cerevisiae"
xref: Reactome:REACT_82012 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine, Danio rerio"
xref: Reactome:REACT_82908 "Cleavage of the damaged pyrimidine, Dictyostelium discoideum"
xref: Reactome:REACT_82952 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine, Caenorhabditis elegans"
xref: Reactome:REACT_83363 "Depyrimidination, Bos taurus"
xref: Reactome:REACT_83543 "Cleavage of the damaged pyrimidine, Sus scrofa"
xref: Reactome:REACT_84079 "Cleavage of the damaged pyrimidine, Caenorhabditis elegans"
xref: Reactome:REACT_84085 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine, Schizosaccharomyces pombe"
xref: Reactome:REACT_84354 "Depyrimidination, Sus scrofa"
xref: Reactome:REACT_85127 "Depyrimidination, Drosophila melanogaster"
xref: Reactome:REACT_85151 "Cleavage of the damaged pyrimidine, Saccharomyces cerevisiae"
xref: Reactome:REACT_85260 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine, Dictyostelium discoideum"
xref: Reactome:REACT_85445 "Depyrimidination, Canis familiaris"
xref: Reactome:REACT_86447 "Depyrimidination, Arabidopsis thaliana"
xref: Reactome:REACT_86911 "Depyrimidination, Gallus gallus"
xref: Reactome:REACT_87272 "Depyrimidination, Escherichia coli"
xref: Reactome:REACT_88575 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine, Gallus gallus"
xref: Reactome:REACT_88843 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine, Staphylococcus aureus N315"
xref: Reactome:REACT_90156 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine, Plasmodium falciparum"
xref: Reactome:REACT_90648 "Cleavage of the damaged pyrimidine, Bos taurus"
xref: Reactome:REACT_91923 "Cleavage of the damaged pyrimidine, Rattus norvegicus"
xref: Reactome:REACT_92110 "Cleavage of the damaged pyrimidine, Drosophila melanogaster"
xref: Reactome:REACT_92614 "Depyrimidination, Dictyostelium discoideum"
xref: Reactome:REACT_93256 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine, Canis familiaris"
xref: Reactome:REACT_93834 "Cleavage of the damaged pyrimidine, Canis familiaris"
xref: Reactome:REACT_94342 "Depyrimidination, Saccharomyces cerevisiae"
xref: Reactome:REACT_94884 "Cleavage of the damaged pyrimidine, Schizosaccharomyces pombe"
xref: Reactome:REACT_95444 "Cleavage of the damaged pyrimidine, Xenopus tropicalis"
xref: Reactome:REACT_96990 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine, Rattus norvegicus"
xref: Reactome:REACT_97972 "Depyrimidination, Danio rerio"
xref: Reactome:REACT_98072 "Cleavage of the damaged pyrimidine, Gallus gallus"
is_a: GO:0006285 ! base-excision repair, AP site formation
is_a: GO:0006304 ! DNA modification
is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process

[Term]
id: GO:0045009
name: chitosome
namespace: cellular_component
def: "An intracellular membrane-bounded particle found in fungi and containing chitin synthase; it synthesizes chitin microfibrils. Chitin synthase activity exists in chitosomes and they are proposed to act as a reservoir for regulated transport of chitin synthase enzymes to the division septum." [ISBN:0198506732, PMID:8970154]
is_a: GO:0016023 ! cytoplasmic, membrane-bounded vesicle

[Term]
id: GO:0045010
name: actin nucleation
namespace: biological_process
def: "The initial step in the formation of an actin filament, in which actin monomers combine to form a new filament. Nucleation is slow relative to the subsequent addition of more monomers to extend the filament." [ISBN:0815316194]
synonym: "actin filament nucleation" EXACT []
is_a: GO:0007015 ! actin filament organization
is_a: GO:0030838 ! positive regulation of actin filament polymerization

[Term]
id: GO:0045012
name: obsolete MHC class II receptor activity
namespace: molecular_function
def: "OBSOLETE. A major histocompatibility complex class II receptor. These display processed antigens from virally-infected or transformed cells. Class-II-positive cells ('antigen-presenting cells') can take up antigens from outside by endocytosis, degrade them into small peptides, and re-export the peptides (now bound to MHC class II protein) to the cell surface. These peptide-MHC class II complexes can then be recognized by specific CD4+ lymphocytes." [ISBN:081533642X, ISBN:0879694971]
comment: This term was made obsolete because it was defined ambiguously, and has therefore been used incorrectly in annotations. To update annotations of gene products that act as receptors for MHC class II protein complexes, use the molecular function term 'MHC class II receptor activity ; GO:0032395'; to update annotations of gene products which are components of MHC class II protein complexes, use the cellular component term 'MHC class II protein complex ; GO:0042613'.
synonym: "class II major histocompatibility complex antigen" RELATED []
synonym: "major histocompatibility complex class II receptor" EXACT []
synonym: "MHC class II receptor activity" EXACT []
is_obsolete: true
consider: GO:0032395
consider: GO:0042613

[Term]
id: GO:0045013
name: carbon catabolite repression of transcription
namespace: biological_process
def: "A transcription regulation process in which the presence of one carbon source leads to a decrease in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources. Carbon catabolite repression is a mechanism of genetic regulation which the accumulation of catabolites of one substance in the cell represses the formation of enzymes that contribute to the catabolism of other substances." [GOC:mah, ISBN:0198506732, PMID:11018147, PMID:18359269, PMID:9618445]
subset: gosubset_prok
synonym: "carbon catabolite repression" EXACT []
synonym: "negative regulation of transcription by carbon catabolites" EXACT [GOC:mah]
is_a: GO:0045892 ! negative regulation of transcription, DNA-templated
is_a: GO:0045990 ! carbon catabolite regulation of transcription

[Term]
id: GO:0045014
name: negative regulation of transcription by glucose
namespace: biological_process
def: "Any process involving glucose that stops, prevents or reduces the rate of transcription. The presence of glucose in the growth medium inhibits the synthesis of certain enzymes in bacteria growing on the medium. For example, transcription of some catabolic operons is under negative control by specific repressors and glucose is an anti-inducer of xylose utilization and glycerol kinase." [ISBN:0198506732, PMID:11018147]
subset: gosubset_prok
synonym: "down regulation of transcription by glucose" EXACT []
synonym: "down-regulation of transcription by glucose" EXACT []
synonym: "downregulation of transcription by glucose" EXACT []
synonym: "glucose effect" EXACT []
synonym: "glucose repression" EXACT []
synonym: "inhibition of transcription by glucose" NARROW []
is_a: GO:0045013 ! carbon catabolite repression of transcription
is_a: GO:0046015 ! regulation of transcription by glucose

[Term]
id: GO:0045015
name: HDEL sequence binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a HDEL sequence, the C terminus tetrapeptide sequence His-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum." [PMID:1327759]
synonym: "HDEL receptor activity" NARROW []
is_a: GO:0046923 ! ER retention sequence binding

[Term]
id: GO:0045016
name: mitochondrial magnesium ion transport
namespace: biological_process
def: "The transport of magnesium ions (Mg2+) into, out of or within a mitochondrion. Transport across the mitochondrial membranes is mediated by a mitochondrial inner membrane protein." [GOC:ai, PMID:11254124]
is_a: GO:0006839 ! mitochondrial transport
is_a: GO:0015693 ! magnesium ion transport

[Term]
id: GO:0045017
name: glycerolipid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycerolipids, any lipid with a glycerol backbone." [GOC:ai]
subset: gosubset_prok
synonym: "glycerolipid anabolism" EXACT []
synonym: "glycerolipid biosynthesis" EXACT []
synonym: "glycerolipid formation" EXACT []
synonym: "glycerolipid synthesis" EXACT []
is_a: GO:0008610 ! lipid biosynthetic process
is_a: GO:0044249 ! cellular biosynthetic process
is_a: GO:0046486 ! glycerolipid metabolic process

[Term]
id: GO:0045018
name: retrograde transport, vacuole to Golgi
namespace: biological_process
def: "The directed movement of substances from the vacuole to the trans-Golgi network; this occurs in yeast via the prevacuolar/endosomal compartment." [PMID:9700156]
synonym: "retrograde transport from the vacuole" EXACT []
is_a: GO:0007034 ! vacuolar transport

[Term]
id: GO:0045019
name: negative regulation of nitric oxide biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide." [GOC:go_curators]
synonym: "down regulation of nitric oxide biosynthetic process" EXACT []
synonym: "down-regulation of nitric oxide biosynthetic process" EXACT []
synonym: "downregulation of nitric oxide biosynthetic process" EXACT []
synonym: "inhibition of nitric oxide biosynthetic process" NARROW []
synonym: "negative regulation of nitric oxide anabolism" EXACT []
synonym: "negative regulation of nitric oxide biosynthesis" EXACT []
synonym: "negative regulation of nitric oxide formation" EXACT []
synonym: "negative regulation of nitric oxide synthesis" EXACT []
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0045428 ! regulation of nitric oxide biosynthetic process
is_a: GO:1903427 ! negative regulation of reactive oxygen species biosynthetic process
is_a: GO:1904406 ! negative regulation of nitric oxide metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006809 ! nitric oxide biosynthetic process
relationship: negatively_regulates GO:0006809 ! nitric oxide biosynthetic process

[Term]
id: GO:0045020
name: obsolete error-prone DNA repair
namespace: biological_process
def: "OBSOLETE. DNA repair pathways that tend to increase the endogenous mutation rate." [GOC:jl, PMID:11459974]
comment: This term was made obsolete because 'error-prone' does not correspond to a repair mechanism, and the term has been superseded by more specific terms.
synonym: "error-prone DNA repair" EXACT []
synonym: "mutagenic DNA repair" EXACT []
is_obsolete: true
consider: GO:0042276

[Term]
id: GO:0045021
name: obsolete error-free DNA repair
namespace: biological_process
def: "OBSOLETE. DNA repair pathways that do not increase the mutation rate above spontaneous background levels, e.g. excision and recombination pathways." [GOC:jl, PMID:11459974]
comment: This term was made obsolete because 'error-free' does not correspond to a repair mechanism, and the term has been superseded by more specific terms.
subset: gosubset_prok
synonym: "error-free DNA repair" EXACT []
is_obsolete: true
consider: GO:0042275
consider: GO:0070987

[Term]
id: GO:0045022
name: early endosome to late endosome transport
namespace: biological_process
def: "The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs." [ISBN:0815316194]
is_a: GO:0016482 ! cytosolic transport
is_a: GO:0098927 ! vesicle-mediated transport between endosomal compartments
relationship: occurs_in GO:0005829 ! cytosol

[Term]
id: GO:0045023
name: G0 to G1 transition
namespace: biological_process
def: "The mitotic cell cycle phase transition whose occurrence commits the cell from the G0 quiescent state to the G1 phase. Under certain conditions, cells exit the cell cycle during G1 and remain in the G0 state as nongrowing, non-dividing (quiescent) cells. Appropriate stimulation of such cells induces them to return to G1 and resume growth and division. The G0 to G1 transition is accompanied by many changes in the program of gene expression." [GOC:mtg_cell_cycle, ISBN:0716731363]
is_a: GO:0022402 ! cell cycle process

[Term]
id: GO:0045024
name: obsolete peptidyl-glutamyl peptide hydrolyzing enzyme activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of bonds after acidic amino acids and after branched chain amino acids." [PMID:11735414]
comment: This term was made obsolete because it represents a gene product.
synonym: "peptidyl-glutamyl peptide hydrolyzing enzyme activity" EXACT []
is_obsolete: true
replaced_by: GO:0070011

[Term]
id: GO:0045025
name: mitochondrial degradosome
namespace: cellular_component
def: "A mitochondrial protein complex with 3' to 5' exoribonuclease activity that participates in intron-independent turnover and processing of mitochondrial transcripts. In humans, the mitochondrial degradosome is a pentameric complex, and in yeast it exists as a heterodimer." [PMID:10397341, PMID:9829834]
synonym: "mtEXO" EXACT [PMID:10397341, PMID:9829834]
is_a: GO:0000177 ! cytoplasmic exosome (RNase complex)
is_a: GO:0098798 ! mitochondrial protein complex

[Term]
id: GO:0045026
name: plasma membrane fusion
namespace: biological_process
alt_id: GO:0006947
def: "The joining of two or more lipid bilayer membranes that surround a cell." [GOC:elh, GOC:mtg_muscle]
synonym: "cell fusion" BROAD []
synonym: "cell-cell fusion" BROAD []
is_a: GO:0044801 ! single-organism membrane fusion

[Term]
id: GO:0045027
name: DNA end binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the ends of DNA that are exposed by the creation of double-strand breaks (DSBs)." [GOC:jl]
is_a: GO:0043566 ! structure-specific DNA binding

[Term]
id: GO:0045028
name: G-protein coupled purinergic nucleotide receptor activity
namespace: molecular_function
def: "Combining with a purine nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:mah, PMID:9755289]
synonym: "G protein coupled purinergic nucleotide receptor activity" EXACT []
synonym: "G-protein-coupled purinergic nucleotide receptor activity" EXACT []
synonym: "P2Y" RELATED []
synonym: "P2Y receptor" RELATED [PMID:9755289]
synonym: "purinergic nucleotide receptor activity, G protein coupled" EXACT []
synonym: "purinergic nucleotide receptor activity, G-protein coupled" EXACT [GOC:bf]
is_a: GO:0001608 ! G-protein coupled nucleotide receptor activity
is_a: GO:0001614 ! purinergic nucleotide receptor activity
relationship: part_of GO:0035589 ! G-protein coupled purinergic nucleotide receptor signaling pathway

[Term]
id: GO:0045029
name: UDP-activated nucleotide receptor activity
namespace: molecular_function
def: "Combining with a nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by UDP." [GOC:mah]
is_a: GO:0015065 ! uridine nucleotide receptor activity

[Term]
id: GO:0045030
name: UTP-activated nucleotide receptor activity
namespace: molecular_function
def: "Combining with a nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by UTP." [GOC:mah]
is_a: GO:0015065 ! uridine nucleotide receptor activity

[Term]
id: GO:0045031
name: ATP-activated adenosine receptor activity
namespace: molecular_function
def: "Combining with adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by ATP." [GOC:mah]
synonym: "ATP-activated nucleotide receptor activity" BROAD []
is_a: GO:0001609 ! G-protein coupled adenosine receptor activity

[Term]
id: GO:0045032
name: ADP-activated adenosine receptor activity
namespace: molecular_function
def: "Combining with adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by ADP." [GOC:mah]
synonym: "ADP-activated nucleotide receptor activity" BROAD []
is_a: GO:0001609 ! G-protein coupled adenosine receptor activity

[Term]
id: GO:0045033
name: peroxisome inheritance
namespace: biological_process
def: "The acquisition of peroxisomes by daughter cells from the mother cell after replication. In Saccharomyces cerevisiae, the number of peroxisomes cells is fairly constant; a subset of the organelles are targeted and segregated to the bud in a highly ordered, vectorial process. Efficient segregation of peroxisomes from mother to bud is dependent on the actin cytoskeleton, and active movement of peroxisomes along actin filaments is driven by the class V myosin motor protein, Myo2p." [PMID:11733545]
comment: Note that 'vectorial' is used in the definition in the mathematical and physical sense of pertaining to 'a quantity having direction as well as magnitude, especially as determining the position of one point in space relative to another.
is_a: GO:0007031 ! peroxisome organization
is_a: GO:0048308 ! organelle inheritance

[Term]
id: GO:0045034
name: obsolete neuroblast division
namespace: biological_process
alt_id: GO:0043345
alt_id: GO:0043346
def: "OBSOLETE. The asymmetrical division of a neuroblast, the neural precursor in the central nervous system, giving rise to another neuroblast and a ganglion mother cell." [PMID:11163136, PMID:11250167]
comment: This term was made obsolete because the definition was incorrect. Not all neuroblasts divide asymmetrically. Neuroblasts give rise to neurons after division.
synonym: "neuroblast cell division" EXACT []
synonym: "neuroblast division" EXACT []
synonym: "neuroblast division (sensu Nematoda and Protostomia)" EXACT []
synonym: "neuroblast division (sensu Vertebrata)" EXACT []
is_obsolete: true

[Term]
id: GO:0045035
name: sensory organ precursor cell division
namespace: biological_process
def: "The series of four asymmetric divisions undergone by the sensory organ precursor cells to generate cells that have distinct cell fates. For example, in the external sensory organ, the precursor cells give rise to one multidendritic neuron and four additional cells (the socket, shaft, sheath cells and the external sense neuron)." [GOC:mah, PMID:11171389, PMID:18295597]
synonym: "sense organ precursor cell division" EXACT [GOC:dph]
is_a: GO:0008356 ! asymmetric cell division
relationship: part_of GO:0007423 ! sensory organ development

[Term]
id: GO:0045036
name: protein targeting to chloroplast
namespace: biological_process
def: "The process of directing proteins towards the chloroplast, usually using signals contained within the protein. Imported proteins are synthesized as cytosolic precursors containing N-terminal uptake-targeting sequences that direct each protein to its correct subcompartment and are subsequently cleaved." [ISBN:0716731363]
synonym: "protein-chloroplast targeting" EXACT []
is_a: GO:0006605 ! protein targeting
is_a: GO:0072596 ! establishment of protein localization to chloroplast
is_a: GO:0072598 ! protein localization to chloroplast
is_a: GO:1902580 ! single-organism cellular localization

[Term]
id: GO:0045037
name: protein import into chloroplast stroma
namespace: biological_process
def: "The targeting and import of proteins into the chloroplast stroma. Import depends on ATP hydrolysis catalyzed by stromal chaperones. Chloroplast stromal proteins, such as the S subunit of rubisco, have a N-terminal stromal-import sequence of about 44 amino acids which is cleaved from the protein precursor after import." [ISBN:0716731363]
synonym: "chloroplast stroma protein import" EXACT []
synonym: "protein transport into chloroplast stroma" EXACT []
is_a: GO:0044743 ! intracellular protein transmembrane import
is_a: GO:0045036 ! protein targeting to chloroplast

[Term]
id: GO:0045038
name: protein import into chloroplast thylakoid membrane
namespace: biological_process
def: "The import of proteins into the chloroplast thylakoid membranes. Proteins that are destined for the thylakoid lumen require two uptake-targeting sequences: the first targets the protein to the stroma, and the second targets the protein from the stroma to the thylakoid lumen. Four separate thylakoid-import systems deal with the proteins once they are in the stroma." [ISBN:0716731363]
synonym: "chloroplast thylakoid membrane protein import" EXACT []
synonym: "protein transport into chloroplast thylakoid membrane" EXACT []
is_a: GO:0006612 ! protein targeting to membrane
is_a: GO:0044743 ! intracellular protein transmembrane import
is_a: GO:0045036 ! protein targeting to chloroplast

[Term]
id: GO:0045039
name: protein import into mitochondrial inner membrane
namespace: biological_process
def: "The process comprising the import of proteins into the mitochondrion from outside the organelle and their insertion into the mitochondrial inner membrane. The translocase of the outer membrane complex mediates the passage of these proteins across the outer membrane, after which they are guided by either of two inner membrane translocase complexes into their final destination in the inner membrane." [GOC:mcc, GOC:vw, PMID:18672008]
synonym: "mitochondrial inner membrane protein import" EXACT []
synonym: "protein transport into mitochondrial inner membrane" EXACT []
is_a: GO:0007007 ! inner mitochondrial membrane organization
is_a: GO:0044743 ! intracellular protein transmembrane import
is_a: GO:0070585 ! protein localization to mitochondrion
is_a: GO:0072657 ! protein localization to membrane
is_a: GO:0090151 ! establishment of protein localization to mitochondrial membrane
is_a: GO:1990542 ! mitochondrial transmembrane transport
relationship: occurs_in GO:0005737 ! cytoplasm
relationship: part_of GO:0006626 ! protein targeting to mitochondrion

[Term]
id: GO:0045040
name: protein import into mitochondrial outer membrane
namespace: biological_process
def: "The process comprising the insertion of proteins from outside the organelle into the mitochondrial outer membrane, mediated by large outer membrane translocase complexes." [GOC:mcc, GOC:vw, PMID:18672008]
synonym: "mitochondrial outer membrane protein import" EXACT []
synonym: "protein insertion into mitochondrial outer membrane" EXACT []
synonym: "protein transport into mitochondrial outer membrane" EXACT []
is_a: GO:0007008 ! outer mitochondrial membrane organization
is_a: GO:0044743 ! intracellular protein transmembrane import
is_a: GO:0070585 ! protein localization to mitochondrion
is_a: GO:0072657 ! protein localization to membrane
is_a: GO:0090151 ! establishment of protein localization to mitochondrial membrane
is_a: GO:1990542 ! mitochondrial transmembrane transport
relationship: occurs_in GO:0005737 ! cytoplasm
relationship: part_of GO:0006626 ! protein targeting to mitochondrion

[Term]
id: GO:0045041
name: protein import into mitochondrial intermembrane space
namespace: biological_process
alt_id: GO:0045043
alt_id: GO:0045044
def: "The import of proteins into the space between the inner and outer mitochondrial membranes." [ISBN:0716731363]
synonym: "mitochondrial intermembrane space protein import" EXACT []
synonym: "protein import into mitochondrial IMS" EXACT []
synonym: "protein import into mitochondrial intermembrane space, direct" NARROW [GOC:mcc]
synonym: "protein import into mitochondrial intermembrane space, nonconservative" NARROW [GOC:mcc]
synonym: "protein transport into mitochondrial IMS" EXACT []
synonym: "protein transport into mitochondrial intermembrane space" EXACT []
is_a: GO:0044743 ! intracellular protein transmembrane import
is_a: GO:0070585 ! protein localization to mitochondrion
is_a: GO:0072655 ! establishment of protein localization to mitochondrion
is_a: GO:1902580 ! single-organism cellular localization
is_a: GO:1990542 ! mitochondrial transmembrane transport
relationship: occurs_in GO:0005737 ! cytoplasm
relationship: part_of GO:0006626 ! protein targeting to mitochondrion

[Term]
id: GO:0045042
name: obsolete protein import into mitochondrial intermembrane space, conservative
namespace: biological_process
def: "OBSOLETE. The conservative import of proteins into the mitochondrial intermembrane space. The entire protein enters the matrix, and then the second targeting sequence directs the protein, presumably bound to a matrix protein, across the inner membrane to the intermembrane space." [ISBN:0716731363]
comment: This term was made obsolete because there is no 'conservative' process of protein import into the mitochondrial intermembrane space that is distinct from the more general parent; furthermore, 'conservative' is used in the literature to describe a pathway of import into the inner membrane rather than into the intermembrane space.
synonym: "conservative mitochondrial IMS protein import" EXACT []
synonym: "conservative mitochondrial intermembrane space protein import" EXACT []
synonym: "conservative protein transport into mitochondrial IMS" EXACT []
synonym: "conservative protein transport into mitochondrial intermembrane space" EXACT []
synonym: "protein import into mitochondrial IMS, conservative" EXACT []
synonym: "protein import into mitochondrial intermembrane space, conservative" EXACT []
synonym: "protein transport into mitochondrial IMS, conservative" EXACT []
synonym: "protein transport into mitochondrial intermembrane space, conservative" EXACT []
is_obsolete: true
consider: GO:0045039
consider: GO:0045041

[Term]
id: GO:0045045
name: obsolete secretory pathway
namespace: biological_process
def: "OBSOLETE. The pathway along which proteins and other substances are moved around and out of the cell. After synthesis on the ribosomes of the endoplasmic reticulum (ER), completed polypeptide chains are moved to the Golgi complex and subsequently sorted to various destinations. Proteins synthesized and sorted in the secretory pathway include not only those that are secreted from the cell but also enzymes and other resident proteins in the lumen of the ER, Golgi, and lysosomes as well as integral proteins in the membranes of these organelles and the plasma membrane." [ISBN:0716731363]
comment: This term was made obsolete because it artificially groups a number of other terms, leading to path problems, its definition is unclear (and lacks genus-differentia features), and it has probably been used incorrectly in annotations.
synonym: "secretory pathway" EXACT []
is_obsolete: true
replaced_by: GO:0032940

[Term]
id: GO:0045046
name: protein import into peroxisome membrane
namespace: biological_process
def: "The targeting of proteins into the peroxisomal membrane. The process is not well understood, but both signals and mechanism differ from those involved in peroxisomal matrix protein import." [ISBN:0716731363, PMID:11687502]
synonym: "peroxisome membrane protein import" EXACT []
synonym: "protein transport into peroxisome membrane" EXACT []
is_a: GO:0006612 ! protein targeting to membrane
is_a: GO:0006625 ! protein targeting to peroxisome
is_a: GO:0015919 ! peroxisomal membrane transport
is_a: GO:0044743 ! intracellular protein transmembrane import

[Term]
id: GO:0045047
name: protein targeting to ER
namespace: biological_process
def: "The process of directing proteins towards the endoplasmic reticulum (ER) using signals contained within the protein. One common mechanism uses a 16- to 30-residue signal sequence, typically located at the N-terminus of the protein and containing positively charged amino acids followed by a continuous stretch of hydrophobic residues, which directs the ribosome to the ER membrane and initiates transport of the growing polypeptide across the ER membrane." [ISBN:0716731363]
synonym: "protein targeting to endoplasmic reticulum" EXACT []
synonym: "protein-endoplasmic reticulum targeting" EXACT []
synonym: "protein-ER targeting" EXACT []
is_a: GO:0006605 ! protein targeting
is_a: GO:0070972 ! protein localization to endoplasmic reticulum
is_a: GO:0072599 ! establishment of protein localization to endoplasmic reticulum
is_a: GO:1902580 ! single-organism cellular localization

[Term]
id: GO:0045048
name: protein insertion into ER membrane
namespace: biological_process
def: "The process that results in incorporation of a protein into an endoplasmic reticulum (ER) membrane. It depends on specific topogenic sequences of amino acids that ensure that a protein acquires the proper orientation during its insertion into the ER membrane." [ISBN:0716731363]
synonym: "integral ER membrane protein localization" EXACT []
synonym: "integral ER membrane protein positioning" EXACT []
synonym: "localization of protein in ER membrane" EXACT []
synonym: "positioning of protein in ER membrane" EXACT []
synonym: "protein insertion into endoplasmic reticulum membrane" EXACT []
synonym: "protein-endoplasmic reticulum insertion" EXACT []
synonym: "protein-ER insertion" EXACT []
is_a: GO:0051205 ! protein insertion into membrane
relationship: part_of GO:0007029 ! endoplasmic reticulum organization
relationship: part_of GO:0033365 ! protein localization to organelle

[Term]
id: GO:0045049
name: protein insertion into ER membrane by N-terminal cleaved signal sequence
namespace: biological_process
def: "A process of protein insertion into the endoplasmic reticulum (ER) membrane in which N-terminal cleaved signal sequences direct polypeptides to the ER." [ISBN:0716731363]
synonym: "N-terminal cleaved signal sequence mediated protein insertion into ER membrane" EXACT []
synonym: "protein insertion into endoplasmic reticulum membrane by N-terminal cleaved signal sequence" EXACT []
synonym: "protein insertion into ER membrane, N-terminal cleaved signal sequence mediated" EXACT []
synonym: "protein-endoplasmic reticulum insertion by N-terminal cleaved signal sequence" EXACT []
synonym: "protein-ER insertion by N-terminal cleaved signal sequence" EXACT []
is_a: GO:0045048 ! protein insertion into ER membrane

[Term]
id: GO:0045050
name: protein insertion into ER membrane by stop-transfer membrane-anchor sequence
namespace: biological_process
def: "A process of protein insertion into the endoplasmic reticulum (ER) membrane in which stop-transfer membrane-anchor sequences become an ER membrane spanning helix." [ISBN:0716731363]
synonym: "protein insertion into endoplasmic reticulum membrane by stop-transfer membrane-anchor sequence" EXACT []
synonym: "protein insertion into ER membrane, stop-transfer membrane-anchor sequence mediated" EXACT []
synonym: "protein-endoplasmic reticulum insertion by stop-transfer membrane-anchor sequence" EXACT []
synonym: "protein-ER insertion by stop-transfer membrane-anchor sequence" EXACT []
synonym: "stop-transfer membrane-anchor sequence mediated protein insertion into ER membrane" EXACT []
is_a: GO:0045048 ! protein insertion into ER membrane

[Term]
id: GO:0045051
name: protein insertion into ER membrane by internal uncleaved signal-anchor sequence
namespace: biological_process
def: "A process of protein insertion into the endoplasmic reticulum (ER) membrane in which signal anchor sequences function as both ER signal sequences and membrane anchor sequences." [ISBN:0716731363]
synonym: "internal uncleaved signal-anchor sequence mediated protein insertion into ER membrane" EXACT []
synonym: "protein insertion into endoplasmic reticulum membrane by internal uncleaved signal-anchor sequence" EXACT []
synonym: "protein insertion into ER membrane, internal uncleaved signal-anchor sequence mediated" EXACT []
synonym: "protein-endoplasmic reticulum insertion by internal uncleaved signal-anchor sequence" EXACT []
synonym: "protein-ER insertion by internal uncleaved signal-anchor sequence" EXACT []
is_a: GO:0045048 ! protein insertion into ER membrane

[Term]
id: GO:0045052
name: protein insertion into ER membrane by GPI attachment sequence
namespace: biological_process
def: "A process of protein insertion into the endoplasmic reticulum (ER) membrane in which proteins become anchored to the phospholipid bilayer by a covalently attached glycosylphosphatidylinositol (GPI) molecule." [ISBN:0716731363]
synonym: "GPI attachment sequence mediated protein insertion into ER membrane" EXACT []
synonym: "protein insertion into endoplasmic reticulum membrane by GPI attachment sequence" EXACT []
synonym: "protein insertion into ER membrane, GPI attachment sequence mediated" EXACT []
synonym: "protein-endoplasmic reticulum insertion by GPI attachment sequence" EXACT []
synonym: "protein-ER insertion by GPI attachment sequence" EXACT []
is_a: GO:0045048 ! protein insertion into ER membrane

[Term]
id: GO:0045053
name: protein retention in Golgi apparatus
namespace: biological_process
def: "The retention of proteins within the Golgi apparatus. Golgi-localized carbohydrate-modifying enzymes have a short N-terminal domain that faces the cytosol, a single transmembrane alpha helix, and a large C-terminal domain that faces the Golgi lumen and that contains the catalytic site. How the membrane-spanning alpha helix in a Golgi enzyme causes its localization and prevents its movement to the plasma membrane is not known." [ISBN:0716731363]
synonym: "maintenance of protein location in Golgi apparatus" RELATED []
synonym: "protein-Golgi retention" EXACT []
synonym: "retention of protein in Golgi" EXACT []
is_a: GO:0032507 ! maintenance of protein location in cell
relationship: part_of GO:0034067 ! protein localization to Golgi apparatus

[Term]
id: GO:0045054
name: constitutive secretory pathway
namespace: biological_process
def: "A process of exocytosis found in all eukaryotic cells, in which transport vesicles destined for the plasma membrane leave the trans-Golgi network in a steady stream. Upon exocytosis, the membrane proteins and lipids in these vesicles provide new components for the plasma membrane, and the soluble proteins inside the vesicles are released into the extracellular space." [GOC:mah, ISBN:0716731363]
synonym: "constitutive exocytosis" EXACT []
is_a: GO:0006887 ! exocytosis

[Term]
id: GO:0045055
name: regulated exocytosis
namespace: biological_process
def: "A process of exocytosis in which soluble proteins and other substances are initially stored in secretory vesicles for later release. It is found mainly in cells that are specialized for secreting products such as hormones, neurotransmitters, or digestive enzymes rapidly on demand." [GOC:mah, ISBN:0716731363]
synonym: "regulated secretory pathway" EXACT []
is_a: GO:0006887 ! exocytosis

[Term]
id: GO:0045056
name: transcytosis
namespace: biological_process
def: "The directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side." [ISBN:0716731363]
xref: Wikipedia:Transcytosis
is_a: GO:0016192 ! vesicle-mediated transport
is_a: GO:0044765 ! single-organism transport

[Term]
id: GO:0045057
name: cisternal progression
namespace: biological_process
def: "The process that results in the physical movement of a new cis-Golgi stack from the cis-position, nearest the endoplasmic reticulum (ER), to the trans position, farthest from the ER, successively becoming first a medial-Golgi cisterna and then a trans-Golgi cisterna." [ISBN:0716731363]
synonym: "cisternal maturation" EXACT []
is_a: GO:0006891 ! intra-Golgi vesicle-mediated transport

[Term]
id: GO:0045058
name: T cell selection
namespace: biological_process
def: "The process in which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation." [ISBN:0781735149, PMID:12414722]
synonym: "T lymphocyte selection" EXACT []
synonym: "T-cell selection" EXACT []
synonym: "T-lymphocyte selection" EXACT []
xref: Wikipedia:Thymocyte
is_a: GO:0002376 ! immune system process
relationship: part_of GO:0030217 ! T cell differentiation

[Term]
id: GO:0045059
name: positive thymic T cell selection
namespace: biological_process
def: "The process of sparing immature T cells in the thymus which react with self-MHC protein complexes with low affinity levels from apoptotic death." [ISBN:0781735149, PMID:12414722]
synonym: "positive thymic T lymphocyte selection" EXACT []
synonym: "positive thymic T-cell selection" EXACT []
synonym: "positive thymic T-lymphocyte selection" EXACT []
is_a: GO:0043368 ! positive T cell selection
is_a: GO:0045061 ! thymic T cell selection

[Term]
id: GO:0045060
name: negative thymic T cell selection
namespace: biological_process
def: "The process of elimination of immature T cells in the thymus which react strongly with self-antigens." [ISBN:0781735149, PMID:12414722]
synonym: "negative thymic T lymphocyte selection" EXACT []
synonym: "negative thymic T-cell selection" EXACT []
synonym: "negative thymic T-lymphocyte selection" EXACT []
is_a: GO:0043383 ! negative T cell selection
is_a: GO:0045061 ! thymic T cell selection

[Term]
id: GO:0045061
name: thymic T cell selection
namespace: biological_process
def: "The process of T cell selection that occurs in the thymus." [ISBN:0781735149, PMID:12414722]
synonym: "thymic T lymphocyte selection" EXACT []
synonym: "thymic T-cell selection" EXACT []
synonym: "thymic T-lymphocyte selection" EXACT []
is_a: GO:0045058 ! T cell selection
relationship: part_of GO:0033077 ! T cell differentiation in thymus

[Term]
id: GO:0045062
name: extrathymic T cell selection
namespace: biological_process
def: "The process of T cell selection that occurs in extrathymic locations, often resulting T cells of distinct specificities from those selected in the thymus." [ISBN:0781735149, PMID:7880383]
synonym: "extrathymic T lymphocyte selection" EXACT []
synonym: "extrathymic T-cell selection" EXACT []
synonym: "extrathymic T-lymphocyte selection" EXACT []
is_a: GO:0045058 ! T cell selection
relationship: part_of GO:0033078 ! extrathymic T cell differentiation

[Term]
id: GO:0045063
name: T-helper 1 cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 1 (Th1) cell. A Th1 cell is a CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma." [CL:0000545, GOC:ebc]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "T-helper 1 cell development" RELATED [GOC:add]
is_a: GO:0042093 ! T-helper cell differentiation
relationship: part_of GO:0042088 ! T-helper 1 type immune response

[Term]
id: GO:0045064
name: T-helper 2 cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized T cell acquires specialized features of a T-helper 2 (Th2) cell. A Th2 cell is a CD4-positive, alpha-beta T cell that has the phenotype GATA-3-positive and produces interleukin-4." [CL:0000546, GOC:ebc]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "T-helper 2 cell development" RELATED [GOC:add]
is_a: GO:0042093 ! T-helper cell differentiation
relationship: part_of GO:0042092 ! type 2 immune response

[Term]
id: GO:0045065
name: cytotoxic T cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized T cell acquires specialized features of a cytotoxic T cell." [GOC:ai]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "cytotoxic T cell development" RELATED [GOC:add]
synonym: "cytotoxic T lymphocyte selection" EXACT []
synonym: "cytotoxic T-cell selection" EXACT []
synonym: "cytotoxic T-lymphocyte selection" EXACT []
is_a: GO:0030217 ! T cell differentiation

[Term]
id: GO:0045066
name: regulatory T cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized T cell acquires specialized features of a regulatory T cell. Regulatory T cells control or suppress immune responses through a variety of mechanisms and subsets include the CD4+CD25+ cell type as well as certain CD8+ cell types." [ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "regulatory T cell development" RELATED [GOC:add]
synonym: "regulatory T lymphocyte differentiation" EXACT []
synonym: "regulatory T-cell differentiation" EXACT []
synonym: "regulatory T-lymphocyte differentiation" EXACT []
synonym: "suppressor T cell differentiation" EXACT []
synonym: "suppressor T lymphocyte differentiation" EXACT []
synonym: "suppressor T-cell differentiation" EXACT []
synonym: "suppressor T-lymphocyte differentiation" EXACT []
is_a: GO:0030217 ! T cell differentiation

[Term]
id: GO:0045067
name: positive extrathymic T cell selection
namespace: biological_process
def: "The process of sparing extrathymically maturing T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death." [ISBN:0781735149, PMID:7880383]
synonym: "positive extrathymic T cell selection" RELATED [GOC:add]
synonym: "positive extrathymic T lymphocyte selection" EXACT []
synonym: "positive extrathymic T-cell selection" EXACT []
synonym: "positive extrathymic T-lymphocyte selection" EXACT []
is_a: GO:0043368 ! positive T cell selection
is_a: GO:0045062 ! extrathymic T cell selection

[Term]
id: GO:0045068
name: negative extrathymic T cell selection
namespace: biological_process
def: "The process of elimination of extrathymically maturing T cells which react strongly with self-antigens." [ISBN:0781735149, PMID:7880383]
synonym: "negative extrathymic T lymphocyte selection" EXACT []
synonym: "negative extrathymic T-cell selection" EXACT []
synonym: "negative extrathymic T-lymphocyte selection" EXACT []
is_a: GO:0043383 ! negative T cell selection
is_a: GO:0045062 ! extrathymic T cell selection

[Term]
id: GO:0045069
name: regulation of viral genome replication
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of viral genome replication." [GOC:ai]
is_a: GO:1903900 ! regulation of viral life cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019079 ! viral genome replication
relationship: regulates GO:0019079 ! viral genome replication

[Term]
id: GO:0045070
name: positive regulation of viral genome replication
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of viral genome replication." [GOC:ai]
synonym: "activation of viral genome replication" NARROW []
synonym: "stimulation of viral genome replication" NARROW []
synonym: "up regulation of viral genome replication" EXACT []
synonym: "up-regulation of viral genome replication" EXACT []
synonym: "upregulation of viral genome replication" EXACT []
is_a: GO:0045069 ! regulation of viral genome replication
is_a: GO:1903902 ! positive regulation of viral life cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0019079 ! viral genome replication
relationship: positively_regulates GO:0019079 ! viral genome replication

[Term]
id: GO:0045071
name: negative regulation of viral genome replication
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication." [GOC:go_curators]
synonym: "down regulation of viral genome replication" EXACT []
synonym: "down-regulation of viral genome replication" EXACT []
synonym: "downregulation of viral genome replication" EXACT []
synonym: "inhibition of viral genome replication" NARROW []
is_a: GO:0045069 ! regulation of viral genome replication
is_a: GO:1903901 ! negative regulation of viral life cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019079 ! viral genome replication
relationship: negatively_regulates GO:0019079 ! viral genome replication

[Term]
id: GO:0045072
name: regulation of interferon-gamma biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma." [GOC:go_curators]
synonym: "regulation of interferon-gamma anabolism" EXACT []
synonym: "regulation of interferon-gamma biosynthesis" EXACT []
synonym: "regulation of interferon-gamma formation" EXACT []
synonym: "regulation of interferon-gamma synthesis" EXACT []
is_a: GO:0032649 ! regulation of interferon-gamma production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042095 ! interferon-gamma biosynthetic process
relationship: regulates GO:0042095 ! interferon-gamma biosynthetic process

[Term]
id: GO:0045073
name: regulation of chemokine biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines." [GOC:go_curators]
synonym: "regulation of chemokine anabolism" EXACT []
synonym: "regulation of chemokine biosynthesis" EXACT []
synonym: "regulation of chemokine formation" EXACT []
synonym: "regulation of chemokine synthesis" EXACT []
is_a: GO:0032642 ! regulation of chemokine production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042033 ! chemokine biosynthetic process
relationship: regulates GO:0042033 ! chemokine biosynthetic process

[Term]
id: GO:0045074
name: regulation of interleukin-10 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-10." [GOC:go_curators]
synonym: "regulation of IL-10 biosynthesis" EXACT []
synonym: "regulation of IL-10 biosynthetic process" EXACT []
synonym: "regulation of interleukin-10 anabolism" EXACT []
synonym: "regulation of interleukin-10 biosynthesis" EXACT []
synonym: "regulation of interleukin-10 formation" EXACT []
synonym: "regulation of interleukin-10 synthesis" EXACT []
is_a: GO:0032653 ! regulation of interleukin-10 production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042091 ! interleukin-10 biosynthetic process
relationship: regulates GO:0042091 ! interleukin-10 biosynthetic process

[Term]
id: GO:0045075
name: regulation of interleukin-12 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-12." [GOC:go_curators]
synonym: "regulation of IL-12 biosynthesis" EXACT []
synonym: "regulation of IL-12 biosynthetic process" EXACT []
synonym: "regulation of interleukin-12 anabolism" EXACT []
synonym: "regulation of interleukin-12 biosynthesis" EXACT []
synonym: "regulation of interleukin-12 formation" EXACT []
synonym: "regulation of interleukin-12 synthesis" EXACT []
is_a: GO:0032655 ! regulation of interleukin-12 production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042090 ! interleukin-12 biosynthetic process
relationship: regulates GO:0042090 ! interleukin-12 biosynthetic process

[Term]
id: GO:0045076
name: regulation of interleukin-2 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2." [GOC:go_curators]
synonym: "regulation of IL-2 biosynthesis" EXACT []
synonym: "regulation of IL-2 biosynthetic process" EXACT []
synonym: "regulation of interleukin-2 anabolism" EXACT []
synonym: "regulation of interleukin-2 biosynthesis" EXACT []
synonym: "regulation of interleukin-2 formation" EXACT []
synonym: "regulation of interleukin-2 synthesis" EXACT []
is_a: GO:0032663 ! regulation of interleukin-2 production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042094 ! interleukin-2 biosynthetic process
relationship: regulates GO:0042094 ! interleukin-2 biosynthetic process

[Term]
id: GO:0045077
name: negative regulation of interferon-gamma biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma." [GOC:go_curators]
synonym: "down regulation of interferon-gamma biosynthetic process" EXACT []
synonym: "down-regulation of interferon-gamma biosynthetic process" EXACT []
synonym: "downregulation of interferon-gamma biosynthetic process" EXACT []
synonym: "inhibition of interferon-gamma biosynthetic process" NARROW []
synonym: "negative regulation of interferon-gamma anabolism" EXACT []
synonym: "negative regulation of interferon-gamma biosynthesis" EXACT []
synonym: "negative regulation of interferon-gamma formation" EXACT []
synonym: "negative regulation of interferon-gamma synthesis" EXACT []
is_a: GO:0032689 ! negative regulation of interferon-gamma production
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045072 ! regulation of interferon-gamma biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042095 ! interferon-gamma biosynthetic process
relationship: negatively_regulates GO:0042095 ! interferon-gamma biosynthetic process

[Term]
id: GO:0045078
name: positive regulation of interferon-gamma biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma." [GOC:go_curators]
synonym: "activation of interferon-gamma biosynthetic process" NARROW []
synonym: "positive regulation of interferon-gamma anabolism" EXACT []
synonym: "positive regulation of interferon-gamma biosynthesis" EXACT []
synonym: "positive regulation of interferon-gamma formation" EXACT []
synonym: "positive regulation of interferon-gamma synthesis" EXACT []
synonym: "stimulation of interferon-gamma biosynthetic process" NARROW []
synonym: "up regulation of interferon-gamma biosynthetic process" EXACT []
synonym: "up-regulation of interferon-gamma biosynthetic process" EXACT []
synonym: "upregulation of interferon-gamma biosynthetic process" EXACT []
is_a: GO:0032729 ! positive regulation of interferon-gamma production
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045072 ! regulation of interferon-gamma biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042095 ! interferon-gamma biosynthetic process
relationship: positively_regulates GO:0042095 ! interferon-gamma biosynthetic process

[Term]
id: GO:0045079
name: negative regulation of chemokine biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines." [GOC:go_curators]
synonym: "down regulation of chemokine biosynthetic process" EXACT []
synonym: "down-regulation of chemokine biosynthetic process" EXACT []
synonym: "downregulation of chemokine biosynthetic process" EXACT []
synonym: "inhibition of chemokine biosynthetic process" NARROW []
synonym: "negative regulation of chemokine anabolism" EXACT []
synonym: "negative regulation of chemokine biosynthesis" EXACT []
synonym: "negative regulation of chemokine formation" EXACT []
synonym: "negative regulation of chemokine synthesis" EXACT []
is_a: GO:0032682 ! negative regulation of chemokine production
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045073 ! regulation of chemokine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042033 ! chemokine biosynthetic process
relationship: negatively_regulates GO:0042033 ! chemokine biosynthetic process

[Term]
id: GO:0045080
name: positive regulation of chemokine biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines." [GOC:go_curators]
synonym: "activation of chemokine biosynthetic process" NARROW []
synonym: "positive regulation of chemokine anabolism" EXACT []
synonym: "positive regulation of chemokine biosynthesis" EXACT []
synonym: "positive regulation of chemokine formation" EXACT []
synonym: "positive regulation of chemokine synthesis" EXACT []
synonym: "stimulation of chemokine biosynthetic process" NARROW []
synonym: "up regulation of chemokine biosynthetic process" EXACT []
synonym: "up-regulation of chemokine biosynthetic process" EXACT []
synonym: "upregulation of chemokine biosynthetic process" EXACT []
is_a: GO:0032722 ! positive regulation of chemokine production
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045073 ! regulation of chemokine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042033 ! chemokine biosynthetic process
relationship: positively_regulates GO:0042033 ! chemokine biosynthetic process

[Term]
id: GO:0045081
name: negative regulation of interleukin-10 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-10." [GOC:go_curators]
synonym: "down regulation of interleukin-10 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-10 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-10 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-10 biosynthetic process" NARROW []
synonym: "negative regulation of IL-10 biosynthesis" EXACT []
synonym: "negative regulation of IL-10 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-10 anabolism" EXACT []
synonym: "negative regulation of interleukin-10 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-10 formation" EXACT []
synonym: "negative regulation of interleukin-10 synthesis" EXACT []
is_a: GO:0032693 ! negative regulation of interleukin-10 production
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045074 ! regulation of interleukin-10 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042091 ! interleukin-10 biosynthetic process
relationship: negatively_regulates GO:0042091 ! interleukin-10 biosynthetic process

[Term]
id: GO:0045082
name: positive regulation of interleukin-10 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-10." [GOC:go_curators]
synonym: "activation of interleukin-10 biosynthetic process" NARROW []
synonym: "positive regulation of IL-10 biosynthesis" EXACT []
synonym: "positive regulation of IL-10 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-10 anabolism" EXACT []
synonym: "positive regulation of interleukin-10 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-10 formation" EXACT []
synonym: "positive regulation of interleukin-10 synthesis" EXACT []
synonym: "stimulation of interleukin-10 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-10 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-10 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-10 biosynthetic process" EXACT []
is_a: GO:0032733 ! positive regulation of interleukin-10 production
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045074 ! regulation of interleukin-10 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042091 ! interleukin-10 biosynthetic process
relationship: positively_regulates GO:0042091 ! interleukin-10 biosynthetic process

[Term]
id: GO:0045083
name: negative regulation of interleukin-12 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-12." [GOC:go_curators]
synonym: "down regulation of interleukin-12 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-12 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-12 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-12 biosynthetic process" NARROW []
synonym: "negative regulation of IL-12 biosynthesis" EXACT []
synonym: "negative regulation of IL-12 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-12 anabolism" EXACT []
synonym: "negative regulation of interleukin-12 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-12 formation" EXACT []
synonym: "negative regulation of interleukin-12 synthesis" EXACT []
is_a: GO:0032695 ! negative regulation of interleukin-12 production
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045075 ! regulation of interleukin-12 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042090 ! interleukin-12 biosynthetic process
relationship: negatively_regulates GO:0042090 ! interleukin-12 biosynthetic process

[Term]
id: GO:0045084
name: positive regulation of interleukin-12 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-12." [GOC:go_curators]
synonym: "activation of interleukin-12 biosynthetic process" NARROW []
synonym: "positive regulation of IL-12 biosynthesis" EXACT []
synonym: "positive regulation of IL-12 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-12 anabolism" EXACT []
synonym: "positive regulation of interleukin-12 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-12 formation" EXACT []
synonym: "positive regulation of interleukin-12 synthesis" EXACT []
synonym: "stimulation of interleukin-12 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-12 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-12 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-12 biosynthetic process" EXACT []
is_a: GO:0032735 ! positive regulation of interleukin-12 production
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045075 ! regulation of interleukin-12 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042090 ! interleukin-12 biosynthetic process
relationship: positively_regulates GO:0042090 ! interleukin-12 biosynthetic process

[Term]
id: GO:0045085
name: negative regulation of interleukin-2 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2." [GOC:go_curators]
synonym: "down regulation of interleukin-2 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-2 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-2 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-2 biosynthetic process" NARROW []
synonym: "negative regulation of IL-2 biosynthesis" EXACT []
synonym: "negative regulation of IL-2 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-2 anabolism" EXACT []
synonym: "negative regulation of interleukin-2 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-2 formation" EXACT []
synonym: "negative regulation of interleukin-2 synthesis" EXACT []
is_a: GO:0032703 ! negative regulation of interleukin-2 production
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045076 ! regulation of interleukin-2 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042094 ! interleukin-2 biosynthetic process
relationship: negatively_regulates GO:0042094 ! interleukin-2 biosynthetic process

[Term]
id: GO:0045086
name: positive regulation of interleukin-2 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2." [GOC:go_curators]
synonym: "activation of interleukin-2 biosynthetic process" NARROW []
synonym: "positive regulation of IL-2 biosynthesis" EXACT []
synonym: "positive regulation of IL-2 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-2 anabolism" EXACT []
synonym: "positive regulation of interleukin-2 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-2 formation" EXACT []
synonym: "positive regulation of interleukin-2 synthesis" EXACT []
synonym: "stimulation of interleukin-2 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-2 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-2 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-2 biosynthetic process" EXACT []
is_a: GO:0032743 ! positive regulation of interleukin-2 production
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045076 ! regulation of interleukin-2 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042094 ! interleukin-2 biosynthetic process
relationship: positively_regulates GO:0042094 ! interleukin-2 biosynthetic process

[Term]
id: GO:0045087
name: innate immune response
namespace: biological_process
alt_id: GO:0002226
def: "Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu]
comment: This term was improved by GO_REF:0000022. It was moved.
synonym: "innate immunity" EXACT [GOC:pg]
synonym: "nonspecific immune response" EXACT []
xref: Reactome:REACT_101086 "Innate Immune System, Bos taurus"
xref: Reactome:REACT_108180 "Innate Immune System, Arabidopsis thaliana"
xref: Reactome:REACT_110518 "Innate Immune System, Taeniopygia guttata"
xref: Reactome:REACT_31297 "Innate Immune System, Xenopus tropicalis"
xref: Reactome:REACT_32992 "Innate Immune System, Gallus gallus"
xref: Reactome:REACT_6802 "Innate Immune System, Homo sapiens"
xref: Reactome:REACT_78575 "Innate Immune System, Canis familiaris"
xref: Reactome:REACT_81815 "Innate Immune System, Saccharomyces cerevisiae"
xref: Reactome:REACT_81962 "Innate Immune System, Dictyostelium discoideum"
xref: Reactome:REACT_86987 "Innate Immune System, Mus musculus"
xref: Reactome:REACT_88681 "Innate Immune System, Drosophila melanogaster"
xref: Reactome:REACT_90618 "Innate Immune System, Caenorhabditis elegans"
xref: Reactome:REACT_90753 "Innate Immune System, Schizosaccharomyces pombe"
xref: Reactome:REACT_94451 "Innate Immune System, Rattus norvegicus"
xref: Reactome:REACT_95471 "Innate Immune System, Sus scrofa"
xref: Reactome:REACT_95642 "Innate Immune System, Oryza sativa"
xref: Reactome:REACT_99610 "Innate Immune System, Danio rerio"
xref: Wikipedia:Innate_immune_system
is_a: GO:0006952 ! defense response
is_a: GO:0006955 ! immune response

[Term]
id: GO:0045088
name: regulation of innate immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc]
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0050776 ! regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045087 ! innate immune response
relationship: regulates GO:0045087 ! innate immune response

[Term]
id: GO:0045089
name: positive regulation of innate immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc]
synonym: "stimulation of innate immune response" NARROW []
synonym: "up regulation of innate immune response" EXACT []
synonym: "up-regulation of innate immune response" EXACT []
synonym: "upregulation of innate immune response" EXACT []
is_a: GO:0031349 ! positive regulation of defense response
is_a: GO:0045088 ! regulation of innate immune response
is_a: GO:0050778 ! positive regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045087 ! innate immune response
relationship: positively_regulates GO:0045087 ! innate immune response

[Term]
id: GO:0045091
name: regulation of single stranded viral RNA replication via double stranded DNA intermediate
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of single stranded viral RNA replication via double stranded DNA intermediate." [GOC:go_curators]
synonym: "regulation of retroviral genome replication" EXACT [GOC:bf, GOC:jl]
is_a: GO:0045069 ! regulation of viral genome replication
is_a: GO:0051052 ! regulation of DNA metabolic process
is_a: GO:0051252 ! regulation of RNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0039692 ! single stranded viral RNA replication via double stranded DNA intermediate
relationship: regulates GO:0039692 ! single stranded viral RNA replication via double stranded DNA intermediate

[Term]
id: GO:0045092
name: interleukin-18 receptor complex
namespace: cellular_component
def: "A protein complex that binds interleukin-18; comprises an alpha and a beta subunit." [GOC:mah, PMID:12759435]
synonym: "IL-18 receptor complex" EXACT [GOC:add]
is_a: GO:0098802 ! plasma membrane receptor complex
relationship: part_of GO:0005887 ! integral component of plasma membrane

[Term]
id: GO:0045093
name: interleukin-18 alpha subunit binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the alpha subunit of interleukin-18. IL-18a is a component of IL-18 that is essential for IL-18 binding on the surface of T-helper 1 cells." [PMID:10653850]
synonym: "IL-18Ra binding" EXACT []
is_a: GO:0042007 ! interleukin-18 binding

[Term]
id: GO:0045094
name: interleukin-18 beta subunit binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the beta subunit of interleukin-18. IL-18b is a ligand non-binding chain and is required for signaling of IL-18 that binds with IL-18a." [PMID:10653850]
synonym: "IL-18Rb binding" EXACT []
is_a: GO:0042007 ! interleukin-18 binding

[Term]
id: GO:0045095
name: keratin filament
namespace: cellular_component
def: "A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins." [ISBN:0716731363]
synonym: "acidic keratin" RELATED []
synonym: "basic/neutral keratin" RELATED []
is_a: GO:0005882 ! intermediate filament

[Term]
id: GO:0045096
name: obsolete acidic keratin
namespace: cellular_component
def: "OBSOLETE. A type of intermediate filament." [ISBN:0716731363, ISBN:0815316194]
comment: This term was made obsolete because it represents a gene product.
synonym: "acidic keratin" EXACT []
synonym: "type I intermediate filament" EXACT []
is_obsolete: true
replaced_by: GO:0045095

[Term]
id: GO:0045097
name: obsolete basic/neutral keratin
namespace: cellular_component
def: "OBSOLETE. A type of intermediate filament." [ISBN:0716731363, ISBN:0815316194]
comment: This term was made obsolete because it represents a gene product.
synonym: "basic/neutral keratin" EXACT []
synonym: "type II intermediate filament" EXACT []
is_obsolete: true
replaced_by: GO:0045095

[Term]
id: GO:0045098
name: type III intermediate filament
namespace: cellular_component
def: "A type of intermediate filament, typically made up of one or more of the proteins vimentin, desmin, glial fibrillary acidic protein (GFAP), and peripherin. Unlike the keratins, the type III proteins can form both homo- and heteropolymeric IF filaments." [ISBN:0716731363]
synonym: "desmin" NARROW []
synonym: "glial fibrillary acidic protein" NARROW []
synonym: "peripherin" NARROW []
synonym: "type III intermediate filament associated protein" NARROW []
synonym: "vimentin" NARROW []
is_a: GO:0005882 ! intermediate filament

[Term]
id: GO:0045099
name: obsolete vimentin
namespace: cellular_component
def: "OBSOLETE. A type of intermediate filament." [ISBN:0716731363]
comment: This term was made obsolete because it represents a gene product.
synonym: "vimentin" EXACT []
is_obsolete: true
replaced_by: GO:0045098

[Term]
id: GO:0045100
name: obsolete desmin
namespace: cellular_component
def: "OBSOLETE. A type of intermediate filament." [ISBN:0815316194]
comment: This term was made obsolete because it represents a gene product.
synonym: "desmin" EXACT []
is_obsolete: true
consider: GO:0045098

[Term]
id: GO:0045101
name: obsolete glial fibrillary acidic protein
namespace: cellular_component
def: "OBSOLETE. Glial fibrillary acidic protein forms filaments in the glial cells that surround neurons and in astrocytes." [ISBN:0716731363]
comment: This term was made obsolete because it represents a gene product.
synonym: "GFAP" EXACT []
synonym: "glial fibrillary acidic protein" EXACT []
is_obsolete: true
consider: GO:0045098

[Term]
id: GO:0045102
name: obsolete peripherin
namespace: cellular_component
def: "OBSOLETE. Peripherin is a type III intermediate filament protein found in neurons of the peripheral nervous system." [ISBN:0716731363]
comment: This term was made obsolete because it represents a gene product.
synonym: "peripherin" EXACT []
is_obsolete: true
consider: GO:0045098

[Term]
id: GO:0045103
name: intermediate filament-based process
namespace: biological_process
def: "Any cellular process that depends upon or alters the intermediate filament cytoskeleton, that part of the cytoskeleton comprising intermediate filaments and their associated proteins." [GOC:ai]
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0045104
name: intermediate filament cytoskeleton organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising intermediate filaments and their associated proteins." [GOC:ai]
synonym: "intermediate filament cytoskeleton organisation" EXACT [GOC:curators]
synonym: "intermediate filament cytoskeleton organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0007010 ! cytoskeleton organization
is_a: GO:0045103 ! intermediate filament-based process
is_a: GO:1902589 ! single-organism organelle organization

[Term]
id: GO:0045105
name: intermediate filament polymerization or depolymerization
namespace: biological_process
def: "Assembly or disassembly of intermediate filaments by the addition or removal of component parts from a filament." [GOC:ai]
is_a: GO:0043933 ! macromolecular complex subunit organization
relationship: part_of GO:0045104 ! intermediate filament cytoskeleton organization

[Term]
id: GO:0045106
name: intermediate filament depolymerization
namespace: biological_process
def: "Disassembly of intermediate filaments by the removal of component monomers from a filament." [GOC:mah, ISBN:0716731363]
is_a: GO:0045105 ! intermediate filament polymerization or depolymerization
is_a: GO:0051261 ! protein depolymerization

[Term]
id: GO:0045107
name: intermediate filament polymerization
namespace: biological_process
def: "Assembly of intermediate filaments by the addition of component monomers to a filament. Polymerization of intermediate filament proteins results from interactions among several distinct binding sites on the constituent proteins. Nuclear lamin head-to-tail polymers arise from one such interaction. Deletion analysis localized the binding sites to the ends of the rod domain that are highly conserved among all intermediate filament proteins. Data indicate that one type of interaction in intermediate filament protein polymerization is the longitudinal binding of dimers via the conserved end segments of the coiled-coil rod domain." [GOC:mah, PMID:8776884]
is_a: GO:0045105 ! intermediate filament polymerization or depolymerization
is_a: GO:0051258 ! protein polymerization

[Term]
id: GO:0045108
name: regulation of intermediate filament polymerization or depolymerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the assembly or disassembly of intermediate filaments by the addition or removal of monomers from a filament; this usually occurs through the opposing action of kinases and phosphatases." [ISBN:0716731363]
is_a: GO:0051493 ! regulation of cytoskeleton organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045105 ! intermediate filament polymerization or depolymerization
relationship: regulates GO:0045105 ! intermediate filament polymerization or depolymerization

[Term]
id: GO:0045109
name: intermediate filament organization
namespace: biological_process
def: "Control of the spatial distribution of intermediate filaments; includes organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:ai]
synonym: "intermediate filament organisation" EXACT [GOC:curators]
is_a: GO:0045104 ! intermediate filament cytoskeleton organization
is_a: GO:0071822 ! protein complex subunit organization

[Term]
id: GO:0045110
name: intermediate filament bundle assembly
namespace: biological_process
def: "The formation of the bundles of intermediate filaments. Intermediate filament-associated proteins (IFAPs) cross-link intermediate filaments with one another, forming a bundle or a network, and with other cell structures, including the plasma membrane. The organization of intermediate filaments and their supportive function in various cells types depends in large part on their linkage to other cell structures via IFAPs." [ISBN:0716731363]
synonym: "tonofilament assembly" NARROW []
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0045109 ! intermediate filament organization

[Term]
id: GO:0045111
name: intermediate filament cytoskeleton
namespace: cellular_component
def: "Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell." [ISBN:0716731363]
is_a: GO:0005856 ! cytoskeleton

[Term]
id: GO:0045112
name: integrin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of integrins, a large family of transmembrane proteins that act as receptors for cell-adhesion molecules." [GOC:go_curators, ISBN:0198506732]
synonym: "integrin anabolism" EXACT []
synonym: "integrin biosynthesis" EXACT []
synonym: "integrin formation" EXACT []
synonym: "integrin synthesis" EXACT []
is_a: GO:0009059 ! macromolecule biosynthetic process
relationship: part_of GO:0007009 ! plasma membrane organization

[Term]
id: GO:0045113
name: regulation of integrin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins." [GOC:go_curators]
synonym: "regulation of integrin anabolism" EXACT []
synonym: "regulation of integrin biosynthesis" EXACT []
synonym: "regulation of integrin formation" EXACT []
synonym: "regulation of integrin synthesis" EXACT []
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
is_a: GO:1903729 ! regulation of plasma membrane organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045112 ! integrin biosynthetic process
relationship: regulates GO:0045112 ! integrin biosynthetic process

[Term]
id: GO:0045114
name: beta 2 integrin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of beta 2 integrins, a subfamily of integrins which contain the beta 2 subunit." [GOC:go_curators]
synonym: "beta 2 integrin anabolism" EXACT []
synonym: "beta 2 integrin biosynthesis" EXACT []
synonym: "beta 2 integrin formation" EXACT []
synonym: "beta 2 integrin synthesis" EXACT []
is_a: GO:0045112 ! integrin biosynthetic process

[Term]
id: GO:0045115
name: regulation of beta 2 integrin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta 2 integrins." [GOC:go_curators]
synonym: "regulation of beta 2 integrin anabolism" EXACT []
synonym: "regulation of beta 2 integrin biosynthesis" EXACT []
synonym: "regulation of beta 2 integrin formation" EXACT []
synonym: "regulation of beta 2 integrin synthesis" EXACT []
is_a: GO:0045113 ! regulation of integrin biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045114 ! beta 2 integrin biosynthetic process
relationship: regulates GO:0045114 ! beta 2 integrin biosynthetic process

[Term]
id: GO:0045116
name: protein neddylation
namespace: biological_process
alt_id: GO:0019943
def: "Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein." [PMID:11698580]
comment: Note that currently, the only known substrates of neddylation are cullin family proteins.
synonym: "RUB1-protein conjugation" EXACT []
is_a: GO:0032446 ! protein modification by small protein conjugation

[Term]
id: GO:0045117
name: azole transport
namespace: biological_process
def: "The directed movement of azoles, heterocyclic compounds found in many biologically important substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators, ISBN:3527307206, Wikipedia:Azole]
is_a: GO:0071702 ! organic substance transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0045118
name: azole transporter activity
namespace: molecular_function
def: "Enables the directed movement of azoles, heterocyclic compound found in many biologically important substances, into, out of or within a cell, or between cells." [GOC:go_curators, ISBN:3527307206, Wikipedia:Azole]
is_a: GO:0090484 ! drug transporter activity
relationship: part_of GO:0045117 ! azole transport

[Term]
id: GO:0045119
name: azole:proton antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + azole(in) = H+(in) + azole(out). Azoles are heterocyclic compounds found in many biologically important substances." [GOC:ai, ISBN:3527307206, Wikipedia:Azole]
synonym: "azole:hydrogen antiporter activity" EXACT []
synonym: "bicyclomycin/sulfathiazole:hydrogen antiporter activity" NARROW []
is_a: GO:0015307 ! drug:proton antiporter activity
is_a: GO:1901474 ! azole transmembrane transporter activity

[Term]
id: GO:0045120
name: pronucleus
namespace: cellular_component
def: "The nucleus of either the ovum or the spermatozoon following fertilization. Thus, in the fertilized ovum, there are two pronuclei, one originating from the ovum, the other from the spermatozoon that brought about fertilization; they approach each other, but do not fuse until just before the first cleavage, when each pronucleus loses its membrane to release its contents." [ISBN:0198506732]
xref: Wikipedia:Pronucleus
is_a: GO:0005634 ! nucleus

[Term]
id: GO:0045121
name: membrane raft
namespace: cellular_component
def: "Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions." [PMID:16645198, PMID:20044567]
synonym: "GEM domain" RELATED []
synonym: "glycolipid-enriched membrane domain" RELATED []
synonym: "lipid raft" EXACT []
xref: Wikipedia:Lipid_raft
is_a: GO:0098857 ! membrane microdomain

[Term]
id: GO:0045122
name: aflatoxin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450." [ISBN:0716731363, ISBN:0815316194]
subset: gosubset_prok
synonym: "aflatoxin anabolism" EXACT []
synonym: "aflatoxin biosynthesis" EXACT []
synonym: "aflatoxin formation" EXACT []
synonym: "aflatoxin synthesis" EXACT []
is_a: GO:0043386 ! mycotoxin biosynthetic process
is_a: GO:0046222 ! aflatoxin metabolic process
is_a: GO:1901378 ! organic heteropentacyclic compound biosynthetic process

[Term]
id: GO:0045123
name: cellular extravasation
namespace: biological_process
def: "The migration of a leukocyte from the blood vessels into the surrounding tissue." [GOC:jl]
synonym: "immune cell cellular extravasation" EXACT []
synonym: "leucocyte cellular extravasation" EXACT []
synonym: "leukocyte cellular extravasation" EXACT []
synonym: "transendothelial leukocyte migration" EXACT [GOC:rl]
xref: Wikipedia:Leukocyte_extravasation
is_a: GO:0050900 ! leukocyte migration

[Term]
id: GO:0045124
name: regulation of bone resorption
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of bone tissue loss (resorption)." [GOC:ai]
is_a: GO:0032844 ! regulation of homeostatic process
is_a: GO:0046850 ! regulation of bone remodeling
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045453 ! bone resorption
relationship: regulates GO:0045453 ! bone resorption

[Term]
id: GO:0045125
name: bioactive lipid receptor activity
namespace: molecular_function
def: "Combining with a bioactive lipid and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. A bioactive lipid is a lipid for which changes in lipid levels result in functional consequences in a variety of cellular processes." [GOC:bf, GOC:mah, PMID:12215548, PMID:18216770]
is_a: GO:0004930 ! G-protein coupled receptor activity

[Term]
id: GO:0045127
name: N-acetylglucosamine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-D-glucosamine + ATP = N-acetyl-D-glucosamine 6-phosphate + ADP + 2 H(+)." [EC:2.7.1.59, RHEA:17420]
subset: gosubset_prok
synonym: "2-acetylamino-2-deoxy-D-glucose kinase activity" EXACT [EC:2.7.1.59]
synonym: "acetylaminodeoxyglucokinase activity" EXACT [EC:2.7.1.59]
synonym: "acetylglucosamine kinase (phosphorylating)" EXACT [EC:2.7.1.59]
synonym: "ATP:2-acetylamino-2-deoxy-D-glucose 6-phosphotransferase activity" EXACT [EC:2.7.1.59]
synonym: "ATP:N-acetyl-D-glucosamine 6-phosphotransferase activity" EXACT [EC:2.7.1.59]
synonym: "GlcNAc kinase activity" EXACT [EC:2.7.1.59]
xref: EC:2.7.1.59
xref: KEGG:R01201
xref: MetaCyc:N-ACETYLGLUCOSAMINE-KINASE-RXN
xref: RHEA:17420
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0045128
name: negative regulation of reciprocal meiotic recombination
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:ai, GOC:dph, GOC:tb]
synonym: "down regulation of meiotic recombination" EXACT []
synonym: "down-regulation of meiotic recombination" EXACT []
synonym: "downregulation of meiotic recombination" EXACT []
synonym: "inhibition of meiotic recombination" NARROW []
synonym: "suppression of meiotic recombination" EXACT []
is_a: GO:0010520 ! regulation of reciprocal meiotic recombination
is_a: GO:0045835 ! negative regulation of meiotic nuclear division
is_a: GO:0045910 ! negative regulation of DNA recombination
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007131 ! reciprocal meiotic recombination
relationship: negatively_regulates GO:0007131 ! reciprocal meiotic recombination

[Term]
id: GO:0045129
name: NAD-independent histone deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction does not require the presence of NAD, and represents the removal of an acetyl group from a histone." [EC:3.5.1.17, RHEA:24551]
synonym: "AcuC" RELATED []
is_a: GO:0004407 ! histone deacetylase activity

[Term]
id: GO:0045130
name: keratan sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + keratan = adenosine 3',5'-bisphosphate + keratan 6'-sulfate." [EC:2.8.2.21]
synonym: "3'-phosphoadenylyl keratan sulfotransferase activity" EXACT [EC:2.8.2.21]
synonym: "3'-phosphoadenylyl-sulfate:keratan 6'-sulfotransferase activity" EXACT [EC:2.8.2.21]
synonym: "3'-phosphoadenylylsulfate:keratan sulfotransferase activity" EXACT [EC:2.8.2.21]
synonym: "keratan sulfate Gal-6-sulfotransferase activity" EXACT []
synonym: "keratan sulfate sulfotransferase activity" EXACT [EC:2.8.2.21]
synonym: "keratan sulphotransferase activity" EXACT []
xref: EC:2.8.2.21
xref: MetaCyc:KERATAN-SULFOTRANSFERASE-RXN
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0045131
name: pre-mRNA branch point binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a pre-mRNA branch point sequence, located upstream of the 3' splice site." [PMID:11691992, PMID:9722632]
is_a: GO:0036002 ! pre-mRNA binding

[Term]
id: GO:0045132
name: meiotic chromosome segregation
namespace: biological_process
def: "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle." [GOC:ai, GOC:mah]
is_a: GO:0098813 ! nuclear chromosome segregation
is_a: GO:1903046 ! meiotic cell cycle process
intersection_of: GO:0098813 ! nuclear chromosome segregation
intersection_of: part_of GO:0007126 ! meiotic nuclear division
relationship: part_of GO:0007126 ! meiotic nuclear division

[Term]
id: GO:0045133
name: 2,3-dihydroxybenzoate 3,4-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-dihydroxybenzoate + O(2) = 2-hydroxy-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+)." [EC:1.13.11.14, RHEA:18480]
synonym: "2,3-dihydroxybenzoate 1,2-dioxygenase activity" EXACT [EC:1.13.11.14]
synonym: "2,3-dihydroxybenzoate oxygenase activity" EXACT [EC:1.13.11.14]
synonym: "2,3-dihydroxybenzoate:oxygen 3,4-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.14]
synonym: "2,3-dihydroxybenzoic oxygenase activity" EXACT [EC:1.13.11.14]
synonym: "o-pyrocatechuate oxygenase activity" EXACT [EC:1.13.11.14]
xref: EC:1.13.11.14
xref: KEGG:R01507
xref: MetaCyc:1.13.11.14-RXN
xref: RHEA:18480
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0045134
name: uridine-diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP + H2O = UMP + phosphate." [EC:3.6.1.6]
synonym: "UDP phosphohydrolase activity" EXACT [KEGG:R00155]
synonym: "UDPase activity" EXACT [EC:3.6.1.6]
synonym: "uridine 5'-diphosphatase activity" EXACT [EC:3.6.1.6]
synonym: "uridine diphosphatase activity" EXACT [EC:3.6.1.6]
xref: EC:3.6.1.6
xref: KEGG:R00155
xref: MetaCyc:RXN-12197
is_a: GO:0017110 ! nucleoside-diphosphatase activity

[Term]
id: GO:0045135
name: poly(beta-D-mannuronate) lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: polysaccharides containing beta-D-mannuronate residues = oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl end. This reaction is the eliminative cleavage of polysaccharides containing beta-D-mannuronate residues to give oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl groups at their ends." [EC:4.2.2.3]
subset: gosubset_prok
synonym: "alginase activity" EXACT [EC:4.2.2.3]
synonym: "alginase I" RELATED [EC:4.2.2.3]
synonym: "alginate lyase activity" EXACT [EC:4.2.2.3]
synonym: "alginate lyase I activity" NARROW [EC:4.2.2.3]
synonym: "poly(beta-D-1,4-mannuronide) lyase activity" EXACT [EC:4.2.2.3]
synonym: "poly(mana) alginate lyase activity" NARROW [EC:4.2.2.3]
xref: EC:4.2.2.3
xref: MetaCyc:4.2.2.3-RXN
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0045136
name: development of secondary sexual characteristics
namespace: biological_process
def: "The process whose specific outcome is the progression of the secondary sexual characteristics over time, from their formation to the mature structures. In humans, these include growth of axillary, chest, and pubic hair, voice changes, testicular/penile enlargement, breast development and menstrual periods. Development occurs in response to sex hormone secretion." [GOC:ai]
is_a: GO:0003006 ! developmental process involved in reproduction

[Term]
id: GO:0045137
name: development of primary sexual characteristics
namespace: biological_process
def: "The process whose specific outcome is the progression of the primary sexual characteristics over time, from their formation to the mature structures. The primary sexual characteristics are the testes in males and the ovaries in females and they develop in response to sex hormone secretion." [GOC:ai]
is_a: GO:0003006 ! developmental process involved in reproduction
relationship: part_of GO:0007275 ! multicellular organism development
relationship: part_of GO:0007548 ! sex differentiation

[Term]
id: GO:0045138
name: nematode male tail tip morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the adult male tail tip is generated and organized. In some species of rhabitid nematodes, the male tail tip undergoes a morphological change such that the most posterior hypodermal cells in the tail (hyp8-11 in C. elegans) fuse and retract anteriorly, changing the shape of the tail from a pointed, tapered cone, or spike, to a rounded, blunt dome." [GOC:kmv, PMID:16806150, PMID:18050419, PMID:21408209, PMID:7409314]
synonym: "male tail morphogenesis" BROAD []
synonym: "male tail tip morphogenesis" RELATED [GOC:kmv]
synonym: "tail tip morphogenesis" RELATED [GOC:kmv]
is_a: GO:0090598 ! male anatomical structure morphogenesis

[Term]
id: GO:0045139
name: obsolete copper sensitivity/resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process.
synonym: "copper sensitivity/resistance" EXACT []
is_obsolete: true
replaced_by: GO:0046688

[Term]
id: GO:0045140
name: inositol phosphoceramide synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: phytoceramide + inositol phosphate = inositol phosphoceramide." [MetaCyc:RXN3O-581, PMID:9405490, PMID:9614099]
synonym: "IPC synthase activity" EXACT []
xref: EC:2.4.1.-
xref: MetaCyc:RXN3O-581
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0045141
name: meiotic telomere clustering
namespace: biological_process
def: "The cell cycle process in which the dynamic reorganization of telomeres occurs in early meiotic prophase, during which meiotic chromosome ends are gathered in a bouquet arrangement at the inner surface of the nuclear envelope proximal to the spindle pole body. This plays an important role in progression through meiosis and precedes synapsis." [GOC:vw, PMID:10690419]
synonym: "bouquet biosynthesis" NARROW []
synonym: "bouquet formation" NARROW []
is_a: GO:0034397 ! telomere localization
is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle
is_a: GO:0090220 ! chromosome localization to nuclear envelope involved in homologous chromosome segregation
is_a: GO:1902580 ! single-organism cellular localization

[Term]
id: GO:0045142
name: triplex DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a DNA triple helix. The formation of triple helical DNA has been evoked in several cellular processes including transcription, replication, and recombination." [PMID:10681538]
is_a: GO:0043566 ! structure-specific DNA binding

[Term]
id: GO:0045143
name: homologous chromosome segregation
namespace: biological_process
alt_id: GO:0007061
def: "The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the first division of the meiotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner; this pairing off, referred to as synapsis, permits genetic recombination. One homolog (both sister chromatids) of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, ISBN:0815316194]
synonym: "meiosis I, chromosome segregation" EXACT []
is_a: GO:0045132 ! meiotic chromosome segregation
intersection_of: GO:0098813 ! nuclear chromosome segregation
intersection_of: part_of GO:0007127 ! meiosis I
relationship: part_of GO:0007127 ! meiosis I

[Term]
id: GO:0045144
name: meiotic sister chromatid segregation
namespace: biological_process
def: "The cell cycle process in which sister chromatids are organized and then physically separated and randomly apportioned to two sets during the second division of the meiotic cell cycle." [GOC:ai, ISBN:0815316194]
synonym: "meiosis II, chromosome segregation" EXACT []
is_a: GO:0000819 ! sister chromatid segregation
is_a: GO:0045132 ! meiotic chromosome segregation
is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle
intersection_of: GO:0000819 ! sister chromatid segregation
intersection_of: part_of GO:0007135 ! meiosis II
relationship: part_of GO:0007135 ! meiosis II

[Term]
id: GO:0045145
name: single-stranded DNA 5'-3' exodeoxyribonuclease activity
namespace: molecular_function
def: "Catalysis of the sequential cleavage of nucleotides (such as mononucleotides or dinucleotides) from a free 5' terminus of a single-stranded DNA molecule." [GOC:ai, GOC:elh, PMID:20086101]
synonym: "single-stranded DNA specific 5'-3' exodeoxyribonuclease activity" RELATED []
synonym: "ssDNA-specific 5'-3' exodeoxyribonuclease activity" RELATED [GOC:mah]
is_a: GO:0008297 ! single-stranded DNA exodeoxyribonuclease activity
is_a: GO:0035312 ! 5'-3' exodeoxyribonuclease activity

[Term]
id: GO:0045146
name: initiation of acetate catabolic process by acetate
namespace: biological_process
def: "The activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate." [PMID:11741859]
subset: gosubset_prok
synonym: "initiation of acetate breakdown by acetate" EXACT []
synonym: "initiation of acetate degradation by acetate" EXACT []
is_a: GO:0043077 ! initiation of acetate catabolic process
relationship: part_of GO:0010034 ! response to acetate

[Term]
id: GO:0045147
name: regulation of initiation of acetate catabolic process by acetate
namespace: biological_process
def: "Any process that modulates the activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of initiation of acetate breakdown by acetate" EXACT []
synonym: "regulation of initiation of acetate degradation by acetate" EXACT []
is_a: GO:0045734 ! regulation of acetate catabolic process
is_a: GO:1901457 ! regulation of response to acetate
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045146 ! initiation of acetate catabolic process by acetate
relationship: regulates GO:0045146 ! initiation of acetate catabolic process by acetate

[Term]
id: GO:0045148
name: tripeptide aminopeptidase activity
namespace: molecular_function
def: "Catalysis of the release of the N-terminal residue from a tripeptide." [EC:3.4.11.4]
subset: gosubset_prok
synonym: "alanine-phenylalanine-proline arylamidase activity" EXACT [EC:3.4.11.4]
synonym: "aminoexotripeptidase activity" EXACT [EC:3.4.11.4]
synonym: "aminotripeptidase activity" EXACT []
synonym: "imidoendopeptidase activity" EXACT [EC:3.4.11.4]
synonym: "lymphopeptidase activity" EXACT [EC:3.4.11.4]
synonym: "peptidase B" RELATED [EC:3.4.11.4]
synonym: "peptidase T" EXACT []
xref: EC:3.4.11.4
xref: MetaCyc:3.4.11.4-RXN
is_a: GO:0004177 ! aminopeptidase activity
is_a: GO:0034701 ! tripeptidase activity

[Term]
id: GO:0045149
name: acetoin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving acetoin, 3-hydroxy-2-butanone, often as part of a fermentation pathway or for use as a carbon source." [GOC:mlg]
subset: gosubset_prok
synonym: "acetoin metabolism" EXACT []
is_a: GO:0042180 ! cellular ketone metabolic process
is_a: GO:1902652 ! secondary alcohol metabolic process

[Term]
id: GO:0045150
name: acetoin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of acetoin, 3-hydroxy-2-butanone." [GOC:mlg]
subset: gosubset_prok
synonym: "acetoin breakdown" EXACT []
synonym: "acetoin catabolism" EXACT []
synonym: "acetoin degradation" EXACT []
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:0045149 ! acetoin metabolic process
is_a: GO:0046164 ! alcohol catabolic process

[Term]
id: GO:0045151
name: acetoin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of acetoin, 3-hydroxy-2-butanone." [GOC:mlg]
subset: gosubset_prok
synonym: "acetoin anabolism" EXACT []
synonym: "acetoin biosynthesis" EXACT []
synonym: "acetoin formation" EXACT []
synonym: "acetoin synthesis" EXACT []
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0045149 ! acetoin metabolic process
is_a: GO:1902653 ! secondary alcohol biosynthetic process

[Term]
id: GO:0045152
name: antisigma factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an antisigma factor, a factor which inhibits the ability of the sigma factor to function as a transcriptional initiator." [GOC:mlg]
subset: gosubset_prok
synonym: "antisigma factor antagonist activity" NARROW []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0045153
name: electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity
namespace: molecular_function
def: "Enables the directed movement of electrons within the CoQH2-cytochrome c reductase complex." [GOC:ai, ISBN:0716731363]
synonym: "cytochrome" RELATED []
synonym: "cytochrome b562" NARROW []
synonym: "cytochrome b566" NARROW []
synonym: "cytochrome c1" NARROW []
synonym: "soluble cytochrome b562" RELATED []
xref: Reactome:REACT_112720 "Electron transfer from ubiquinol to cytochrome c of complex III, Canis familiaris"
xref: Reactome:REACT_112947 "Electron transfer from ubiquinol to cytochrome c of complex III, Drosophila melanogaster"
xref: Reactome:REACT_113468 "Electron transfer from ubiquinol to cytochrome c of complex III, Rattus norvegicus"
xref: Reactome:REACT_113728 "Electron transfer from ubiquinol to cytochrome c of complex III, Bos taurus"
xref: Reactome:REACT_115341 "Electron transfer from ubiquinol to cytochrome c of complex III, Sus scrofa"
xref: Reactome:REACT_6300 "Electron transfer from ubiquinol to cytochrome c of complex III, Homo sapiens"
xref: Reactome:REACT_79763 "Electron transfer from ubiquinol to cytochrome c of complex III, Taeniopygia guttata"
xref: Reactome:REACT_89051 "Electron transfer from ubiquinol to cytochrome c of complex III, Danio rerio"
xref: Reactome:REACT_93718 "Electron transfer from ubiquinol to cytochrome c of complex III, Gallus gallus"
xref: Reactome:REACT_98829 "Electron transfer from ubiquinol to cytochrome c of complex III, Mus musculus"
is_a: GO:0009055 ! electron carrier activity

[Term]
id: GO:0045154
name: electron transporter, transferring electrons within cytochrome c oxidase complex activity
namespace: molecular_function
def: "Enables the directed movement of electrons within the cytochrome c oxidase complex." [GOC:ai, ISBN:0716731363]
synonym: "cytochrome" RELATED []
synonym: "cytochrome a" NARROW []
synonym: "cytochrome a3/copper complex" NARROW []
is_a: GO:0009055 ! electron carrier activity

[Term]
id: GO:0045155
name: electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity
namespace: molecular_function
def: "Enables the directed movement of electrons from the CoQH2-cytochrome c reductase complex and the cytochrome c oxidase complex." [GOC:ai, ISBN:0716731363]
subset: gosubset_prok
synonym: "cytochrome" RELATED []
synonym: "cytochrome c" NARROW []
is_a: GO:0009055 ! electron carrier activity

[Term]
id: GO:0045156
name: electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
namespace: molecular_function
def: "Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis." [GOC:ai, ISBN:0716731363]
subset: gosubset_prok
synonym: "cytochrome" RELATED []
synonym: "cytochrome bc1 complex" NARROW []
is_a: GO:0009055 ! electron carrier activity

[Term]
id: GO:0045157
name: electron transporter, transferring electrons within the noncyclic electron transport pathway of photosynthesis activity
namespace: molecular_function
def: "Enables the directed movement of electrons within the noncyclic electron transport pathway of photosynthesis." [GOC:ai, ISBN:0716731363]
synonym: "cytochrome" RELATED []
is_a: GO:0009055 ! electron carrier activity

[Term]
id: GO:0045158
name: electron transporter, transferring electrons within cytochrome b6/f complex of photosystem II activity
namespace: molecular_function
def: "Enables the directed movement of electrons within the cytochrome b6/f complex of photosystem II." [GOC:ai, ISBN:0716731363]
subset: gosubset_prok
synonym: "cytochrome" RELATED []
synonym: "cytochrome b/b6" RELATED []
synonym: "cytochrome b6" NARROW []
synonym: "cytochrome f" NARROW []
is_a: GO:0009055 ! electron carrier activity

[Term]
id: GO:0045159
name: myosin II binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a class II myosin, any member of the class of 'conventional' double-headed myosins that includes muscle myosin." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
is_a: GO:0017022 ! myosin binding

[Term]
id: GO:0045160
name: myosin I complex
namespace: cellular_component
def: "A myosin complex containing a class I myosin heavy chain and associated light chains; myosin I heavy chains are single-headed, possess tails of various lengths, and do not self-associate into bipolar filaments; myosin I complexes are involved in diverse processes related to membrane traffic and cell movement." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, PMID:9438839]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0045161
name: neuronal ion channel clustering
namespace: biological_process
def: "The process in which voltage-gated ion channels become localized to distinct subcellular domains in the neuron. Specific targeting, clustering, and maintenance of these channels in their respective domains are essential to achieve high conduction velocities of action potential propagation." [PMID:11456440]
is_a: GO:0044802 ! single-organism membrane organization
relationship: part_of GO:0042551 ! neuron maturation

[Term]
id: GO:0045162
name: clustering of voltage-gated sodium channels
namespace: biological_process
def: "The process in which voltage-gated sodium channels become localized together in high densities. In animals, nodes of Ranvier differ dramatically from internodal axonal regions in very high densities of voltage-dependent sodium (Nav) channels responsible for the rapid, inward ionic currents that produce membrane depolarization." [PMID:11456440]
synonym: "clustering of voltage gated sodium channels" EXACT []
synonym: "clustering of voltage-dependent sodium channels" EXACT []
synonym: "Nav channel clustering" EXACT []
synonym: "voltage-gated sodium channel clustering" EXACT []
is_a: GO:0045161 ! neuronal ion channel clustering

[Term]
id: GO:0045163
name: clustering of voltage-gated potassium channels
namespace: biological_process
def: "The process in which voltage-gated potassium channels become localized together in high densities. In animals, voltage-gated potassium (Kv) channels are clustered beneath the myelin sheath in regions immediately adjacent to paranodes, called juxtaparanodes, and along the inner mesaxon within the internode." [PMID:11456440]
synonym: "clustering of voltage gated potassium channels" EXACT []
synonym: "clustering of voltage-dependent potassium channels" EXACT []
synonym: "Kv channel clustering" EXACT []
synonym: "voltage-gated potassium channel clustering" EXACT []
is_a: GO:0045161 ! neuronal ion channel clustering

[Term]
id: GO:0045164
name: obsolete secretin (sensu Mammalia)
namespace: molecular_function
def: "OBSOLETE. Secretin is a hormone that takes part in the digestion process. It also has effects on organs other than gastrointestinal tract." [PMID:11320551]
comment: This term was made obsolete because it represents a gene product rather than a molecular function.
synonym: "secretin (sensu Mammalia)" EXACT []
is_obsolete: true
consider: GO:0046659

[Term]
id: GO:0045165
name: cell fate commitment
namespace: biological_process
def: "The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [ISBN:0716731185]
comment: Note that this term was 'cell fate determination' but the term name was changed to better match its existing definition and the child term 'cell fate determination; GO:0001709' was also created.
is_a: GO:0048869 ! cellular developmental process
relationship: part_of GO:0030154 ! cell differentiation

[Term]
id: GO:0045167
name: asymmetric protein localization involved in cell fate determination
namespace: biological_process
def: "Any process in which a protein is transported to, or maintained in, a specific asymmetric distribution, resulting in the formation of daughter cells of different types." [GOC:ai]
synonym: "asymmetric protein localisation involved in cell fate determination" EXACT [GOC:mah]
synonym: "asymmetric protein localization involved in cell fate commitment" EXACT []
synonym: "asymmetric protein localization resulting in cell fate commitment" EXACT []
synonym: "cell fate commitment, asymmetric protein localization" EXACT []
is_a: GO:0008105 ! asymmetric protein localization
intersection_of: GO:0008105 ! asymmetric protein localization
intersection_of: part_of GO:0001709 ! cell fate determination
relationship: part_of GO:0001709 ! cell fate determination

[Term]
id: GO:0045168
name: cell-cell signaling involved in cell fate commitment
namespace: biological_process
def: "Signaling at long or short range between cells that results in the commitment of a cell to a certain fate." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "cell fate commitment, cell-cell signaling" EXACT []
synonym: "cell fate commitment, cell-cell signalling" EXACT []
synonym: "cell-cell signaling during in cell fate commitment" EXACT []
synonym: "cell-cell signaling resulting in cell fate commitment" EXACT []
synonym: "cell-cell signalling during cell fate commitment" EXACT []
synonym: "cell-cell signalling involved in cell fate specification" NARROW [GOC:dph, GOC:tb]
synonym: "cell-cell signalling resulting in cell fate commitment" EXACT []
is_a: GO:0007267 ! cell-cell signaling
intersection_of: GO:0007267 ! cell-cell signaling
intersection_of: part_of GO:0045165 ! cell fate commitment
relationship: part_of GO:0045165 ! cell fate commitment

[Term]
id: GO:0045169
name: fusome
namespace: cellular_component
def: "A large intracellular spectrin-rich structure that has been found in insect germline cells and mammalian hematopoietic cells. The fusome is an elongated, branched structure, formed from the spherical spectrosome organelle." [GOC:bf, PMID:12655376]
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0045170
name: spectrosome
namespace: cellular_component
def: "A germline specific spherical organelle, rich in membrane skeletal proteins. Precursor to the fusome." [GOC:bf]
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0045171
name: intercellular bridge
namespace: cellular_component
def: "A direct connection between the cytoplasm of two cells that is formed following the completion of cleavage furrow ingression during cell division. They are usually present only briefly prior to completion of cytokinesis. However, in some cases, such as the bridges between germ cells during their development, they become stabilised." [PMID:9635420]
is_a: GO:0044421 ! extracellular region part

[Term]
id: GO:0045172
name: germline ring canal
namespace: cellular_component
def: "Germline specific intercellular bridge. During cyst formation in insects, ring canals interconnect the cells of the cyst, facilitating the passage of cytoplasmic components between cells." [GOC:mtg_sensu, PMID:9635420, PMID:9655801]
is_a: GO:0045171 ! intercellular bridge

[Term]
id: GO:0045173
name: O-sialoglycoprotein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of O-sialoglycoproteins, glycoproteins which contain sialic acid as one of their carbohydrates. They are often found on or in the cell or tissue membranes and participate in a variety of biological activities." [GOC:go_curators, PMID:8824323]
subset: gosubset_prok
synonym: "O-sialoglycoprotein breakdown" EXACT []
synonym: "O-sialoglycoprotein catabolism" EXACT []
synonym: "O-sialoglycoprotein degradation" EXACT []
is_a: GO:0006516 ! glycoprotein catabolic process

[Term]
id: GO:0045174
name: glutathione dehydrogenase (ascorbate) activity
namespace: molecular_function
def: "Catalysis of the reaction: dehydroascorbate + 2 glutathione = L-ascorbate + glutathione disulfide." [EC:1.8.5.1, RHEA:24427]
synonym: "dehydroascorbate reductase activity" EXACT []
synonym: "dehydroascorbic acid reductase activity" EXACT [EC:1.8.5.1]
synonym: "dehydroascorbic reductase activity" EXACT [EC:1.8.5.1]
synonym: "DHA reductase activity" EXACT [EC:1.8.5.1]
synonym: "GDOR" RELATED [EC:1.8.5.1]
synonym: "glutathione dehydroascorbate reductase activity" EXACT [EC:1.8.5.1]
synonym: "glutathione:dehydroascorbate oxidoreductase activity" EXACT [EC:1.8.5.1]
synonym: "glutathione:dehydroascorbic acid oxidoreductase activity" EXACT [EC:1.8.5.1]
xref: EC:1.8.5.1
xref: KEGG:R01108
xref: MetaCyc:1.8.5.1-RXN
xref: Reactome:REACT_103179 "Reduction of dehydroascorbate to ascorbate, Taeniopygia guttata"
xref: Reactome:REACT_107812 "Reduction of dehydroascorbate to ascorbate, Gallus gallus"
xref: Reactome:REACT_11095 "Reduction of dehydroascorbate to ascorbate, Homo sapiens"
xref: Reactome:REACT_114041 "Reduction of dehydroascorbate to ascorbate, Arabidopsis thaliana"
xref: Reactome:REACT_114537 "Reduction of dehydroascorbate to ascorbate, Oryza sativa"
xref: Reactome:REACT_114703 "Reduction of dehydroascorbate to ascorbate, Danio rerio"
xref: Reactome:REACT_34623 "Reduction of dehydroascorbate to ascorbate, Canis familiaris"
xref: Reactome:REACT_77681 "Reduction of dehydroascorbate to ascorbate, Xenopus tropicalis"
xref: Reactome:REACT_81744 "Reduction of dehydroascorbate to ascorbate, Mus musculus"
xref: Reactome:REACT_93601 "Reduction of dehydroascorbate to ascorbate, Bos taurus"
xref: Reactome:REACT_97717 "Reduction of dehydroascorbate to ascorbate, Rattus norvegicus"
xref: Reactome:REACT_97930 "Reduction of dehydroascorbate to ascorbate, Sus scrofa"
xref: RHEA:24427
is_a: GO:0015038 ! glutathione disulfide oxidoreductase activity
is_a: GO:0016209 ! antioxidant activity
is_a: GO:0016672 ! oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor

[Term]
id: GO:0045175
name: basal protein localization
namespace: biological_process
def: "Any process in which a protein is transported to, or maintained in, basal regions of the cell." [GOC:bf]
synonym: "basal protein localisation" EXACT [GOC:mah]
synonym: "establishment and maintenance of basal protein localization" EXACT []
synonym: "establishment and maintenance of protein localization in basal part of cell" EXACT []
is_a: GO:0008105 ! asymmetric protein localization

[Term]
id: GO:0045176
name: apical protein localization
namespace: biological_process
def: "Any process in which a protein is transported to, or maintained in, apical regions of the cell." [GOC:bf]
synonym: "apical protein localisation" EXACT [GOC:mah]
synonym: "establishment and maintenance of apical protein localization" EXACT []
synonym: "establishment and maintenance of protein localization in apical part of cell" EXACT []
is_a: GO:0008105 ! asymmetric protein localization

[Term]
id: GO:0045177
name: apical part of cell
namespace: cellular_component
def: "The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194]
subset: goslim_pir
is_a: GO:0044464 ! cell part

[Term]
id: GO:0045178
name: basal part of cell
namespace: cellular_component
def: "The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0185316194]
subset: goslim_pir
is_a: GO:0044464 ! cell part

[Term]
id: GO:0045179
name: apical cortex
namespace: cellular_component
def: "The region that lies just beneath the plasma membrane on the apical edge of a cell." [GOC:bf]
is_a: GO:0099738 ! cell cortex region
intersection_of: GO:0099738 ! cell cortex region
intersection_of: part_of GO:0045177 ! apical part of cell
relationship: part_of GO:0045177 ! apical part of cell

[Term]
id: GO:0045180
name: basal cortex
namespace: cellular_component
def: "The region that lies just beneath the plasma membrane on the basal edge of a cell." [GOC:bf]
is_a: GO:0099738 ! cell cortex region
intersection_of: GO:0099738 ! cell cortex region
intersection_of: part_of GO:0045178 ! basal part of cell
relationship: part_of GO:0045178 ! basal part of cell

[Term]
id: GO:0045181
name: glutamate synthase activity, NAD(P)H as acceptor
namespace: molecular_function
def: "Catalysis of the reaction: 2 L-glutamate + NAD(P)+ = L-glutamine + 2-oxoglutarate + NAD(P)H + H+." [EC:1.4.1.13, EC:1.4.1.14]
subset: gosubset_prok
synonym: "glutamate synthase activity, NADH or NADPH as acceptor" RELATED []
xref: EC:1.4.1.-
is_a: GO:0015930 ! glutamate synthase activity
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

[Term]
id: GO:0045182
name: translation regulator activity
namespace: molecular_function
def: "Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome." [GOC:ai]
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "translation factor activity" EXACT []
is_a: GO:0003674 ! molecular_function
relationship: part_of GO:0006417 ! regulation of translation

[Term]
id: GO:0045183
name: translation factor activity, non-nucleic acid binding
namespace: molecular_function
def: "A translation regulator activity that does not involve binding to nucleic acids." [GOC:ai, GOC:dph, GOC:tb]
subset: gosubset_prok
is_a: GO:0045182 ! translation regulator activity

[Term]
id: GO:0045184
name: establishment of protein localization
namespace: biological_process
def: "The directed movement of a protein to a specific location." [GOC:bf]
subset: gosubset_prok
synonym: "establishment of protein localisation" EXACT [GOC:mah]
synonym: "protein positioning" EXACT []
synonym: "protein recruitment" EXACT []
is_a: GO:0051234 ! establishment of localization
relationship: part_of GO:0008104 ! protein localization

[Term]
id: GO:0045185
name: maintenance of protein location
namespace: biological_process
def: "Any process in which a protein is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of proteins that do move away." [GOC:bf]
subset: gosubset_prok
synonym: "active protein retrieval" NARROW []
synonym: "maintenance of protein localization" RELATED [GOC:dph, GOC:tb]
synonym: "protein retention" NARROW []
synonym: "protein sequestering" NARROW []
is_a: GO:0051235 ! maintenance of location
relationship: part_of GO:0008104 ! protein localization

[Term]
id: GO:0045186
name: zonula adherens assembly
namespace: biological_process
def: "Assembly of the zonula adherens, a cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells." [GOC:bf]
is_a: GO:0007043 ! cell-cell junction assembly
is_a: GO:0034333 ! adherens junction assembly
relationship: part_of GO:0043297 ! apical junction assembly

[Term]
id: GO:0045187
name: regulation of circadian sleep/wake cycle, sleep
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sleep; a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:jl, ISBN:0192800981]
synonym: "regulation of sleep" EXACT []
is_a: GO:0042749 ! regulation of circadian sleep/wake cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050802 ! circadian sleep/wake cycle, sleep
relationship: regulates GO:0050802 ! circadian sleep/wake cycle, sleep

[Term]
id: GO:0045188
name: regulation of circadian sleep/wake cycle, non-REM sleep
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of non-rapid eye movement sleep." [GOC:go_curators]
synonym: "regulation of non-REM sleep" EXACT []
is_a: GO:0045187 ! regulation of circadian sleep/wake cycle, sleep
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042748 ! circadian sleep/wake cycle, non-REM sleep
relationship: regulates GO:0042748 ! circadian sleep/wake cycle, non-REM sleep

[Term]
id: GO:0045189
name: connective tissue growth factor biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of CTGF, produced by human umbilical vein endothelial cells and by skin fibroblasts after activation with TGF-beta." [http://www.copewithcytokines.de]
synonym: "connective tissue growth factor anabolism" EXACT []
synonym: "connective tissue growth factor biosynthesis" EXACT []
synonym: "connective tissue growth factor formation" EXACT []
synonym: "connective tissue growth factor synthesis" EXACT []
synonym: "CTGF biosynthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032601 ! connective tissue growth factor production

[Term]
id: GO:0045190
name: isotype switching
namespace: biological_process
def: "The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus." [ISBN:0781735149]
comment: Note that IgM and IgD can be coexpressed by B cells via an alternate splicing mechanism, but true recombinational isotype switching to IgD has been demonstrated as well. Note that this term is best used to annotate gene products which are involved in the mechanism of DNA recombination used in isotype switching, like the B cell specific Swap70 factor in the mouse, rather than gene products which promote isotype switching such as cytokines or co-stimulatory molecules, which should instead be annotated to 'regulation of isotype switching ; GO:0045191'.
synonym: "class switch recombination" EXACT []
synonym: "class switching" EXACT []
synonym: "isotype switch recombination" EXACT []
xref: Wikipedia:Immunoglobulin_class_switching
is_a: GO:0002204 ! somatic recombination of immunoglobulin genes involved in immune response
is_a: GO:0002312 ! B cell activation involved in immune response
is_a: GO:0044710 ! single-organism metabolic process

[Term]
id: GO:0045191
name: regulation of isotype switching
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of isotype switching." [GOC:ai]
synonym: "regulation of class switch recombination" EXACT []
synonym: "regulation of class switching" EXACT []
synonym: "regulation of isotype switch recombination" EXACT []
is_a: GO:0000018 ! regulation of DNA recombination
is_a: GO:0002637 ! regulation of immunoglobulin production
is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response
is_a: GO:0050864 ! regulation of B cell activation
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045190 ! isotype switching
relationship: regulates GO:0045190 ! isotype switching

[Term]
id: GO:0045192
name: obsolete low-density lipoprotein catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of low-density lipoproteins, also known as beta lipoproteins, one of the classes of lipoproteins found in the bloodstream of animals, acting as a carrier for cholesterol and fats." [GOC:go_curators, ISBN:0198506732]
comment: This term was made obsolete because low-density lipoprotein is a macromolecular complex, not a single class of molecule; its degradation involves the dissociation of non-covalently attached constituents as well as some breaking and reforming of covalent bonds.
synonym: "LDL catabolic process" EXACT []
synonym: "LDL catabolism" EXACT []
synonym: "low-density lipoprotein breakdown" EXACT []
synonym: "low-density lipoprotein catabolic process" EXACT []
synonym: "low-density lipoprotein catabolism" EXACT []
synonym: "low-density lipoprotein degradation" EXACT []
is_obsolete: true

[Term]
id: GO:0045193
name: obsolete acetylated low-density lipoprotein catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of acetylated low-density lipoproteins." [GOC:go_curators]
comment: This term was made obsolete because low-density lipoprotein is a macromolecular complex, not a single class of molecule; its degradation involves the dissociation of non-covalently attached constituents as well as some breaking and reforming of covalent bonds.
synonym: "Ac-LDL catabolic process" EXACT []
synonym: "Ac-LDL catabolism" EXACT []
synonym: "acetylated low-density lipoprotein breakdown" EXACT []
synonym: "acetylated low-density lipoprotein catabolic process" EXACT []
synonym: "acetylated low-density lipoprotein catabolism" EXACT []
synonym: "acetylated low-density lipoprotein degradation" EXACT []
is_obsolete: true

[Term]
id: GO:0045194
name: obsolete oxidized low-density lipoprotein catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of oxidized low-density lipoproteins." [GOC:go_curators]
comment: This term was made obsolete because low-density lipoprotein is a macromolecular complex, not a single class of molecule; its degradation involves the dissociation of non-covalently attached constituents as well as some breaking and reforming of covalent bonds.
synonym: "Ox-LDL catabolic process" EXACT []
synonym: "Ox-LDL catabolism" EXACT []
synonym: "oxidized low-density lipoprotein breakdown" EXACT []
synonym: "oxidized low-density lipoprotein catabolic process" EXACT []
synonym: "oxidized low-density lipoprotein catabolism" EXACT []
synonym: "oxidized low-density lipoprotein degradation" EXACT []
is_obsolete: true

[Term]
id: GO:0045195
name: obsolete gallstone formation
namespace: biological_process
def: "OBSOLETE. The formation of gallstones, hard, crystal-like accretions of cholesterol and bile pigments which develop when bile contains too much cholesterol and not enough bile." [http://www.ddc.musc.edu/ddc_pro/pro_development/basic_science/gallstones.htm]
comment: This term was made obsolete because the process it represents is pathological.
synonym: "gallstone formation" EXACT []
is_obsolete: true

[Term]
id: GO:0045196
name: establishment or maintenance of neuroblast polarity
namespace: biological_process
alt_id: GO:0043339
alt_id: GO:0043342
def: "Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system." [GOC:bf, GOC:mah, GOC:mtg_sensu, PMID:19375318, PMID:20066083]
synonym: "establishment and/or maintenance of neuroblast cell polarity" EXACT []
is_a: GO:0007163 ! establishment or maintenance of cell polarity
relationship: part_of GO:0055059 ! asymmetric neuroblast division

[Term]
id: GO:0045197
name: establishment or maintenance of epithelial cell apical/basal polarity
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah]
is_a: GO:0035088 ! establishment or maintenance of apical/basal cell polarity

[Term]
id: GO:0045198
name: establishment of epithelial cell apical/basal polarity
namespace: biological_process
def: "The specification and formation of the apicobasal polarity of an epithelial cell." [GOC:ascb_2009, GOC:bf, GOC:dph, GOC:tb]
is_a: GO:0030859 ! polarized epithelial cell differentiation
is_a: GO:0035089 ! establishment of apical/basal cell polarity
is_a: GO:0045197 ! establishment or maintenance of epithelial cell apical/basal polarity
is_a: GO:0090162 ! establishment of epithelial cell polarity

[Term]
id: GO:0045199
name: maintenance of epithelial cell apical/basal polarity
namespace: biological_process
def: "The maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf]
is_a: GO:0035090 ! maintenance of apical/basal cell polarity
is_a: GO:0045197 ! establishment or maintenance of epithelial cell apical/basal polarity

[Term]
id: GO:0045200
name: establishment of neuroblast polarity
namespace: biological_process
alt_id: GO:0043340
alt_id: GO:0043343
def: "The specification and formation of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system." [GOC:bf, GOC:mtg_sensu]
synonym: "establishment of neuroblast cell polarity" EXACT []
is_a: GO:0030010 ! establishment of cell polarity
is_a: GO:0045196 ! establishment or maintenance of neuroblast polarity

[Term]
id: GO:0045201
name: maintenance of neuroblast polarity
namespace: biological_process
alt_id: GO:0043341
alt_id: GO:0043344
def: "The maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system." [GOC:bf, GOC:mtg_sensu]
synonym: "maintenance of neuroblast cell polarity" EXACT []
is_a: GO:0030011 ! maintenance of cell polarity
is_a: GO:0045196 ! establishment or maintenance of neuroblast polarity

[Term]
id: GO:0045202
name: synapse
namespace: cellular_component
def: "The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
subset: goslim_pir
subset: goslim_synapse
synonym: "electrotonic synapse" RELATED [NIF_Subcellular:sao1311109124]
synonym: "mixed synapse" NARROW [NIF_Subcellular:sao1506103497]
synonym: "synaptic junction" EXACT []
xref: NIF_Subcellular:sao914572699
xref: Wikipedia:Chemical_synapse
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0045203
name: integral component of cell outer membrane
namespace: cellular_component
def: "The component of the cell outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators, GOC:mtg_sensu]
subset: gosubset_prok
synonym: "integral to cell outer membrane" NARROW []
synonym: "integral to external membrane" RELATED []
synonym: "integral to outer membrane" RELATED []
is_a: GO:0016021 ! integral component of membrane
is_a: GO:0031230 ! intrinsic component of cell outer membrane
intersection_of: GO:0016021 ! integral component of membrane
intersection_of: part_of GO:0009279 ! cell outer membrane
relationship: part_of GO:0009279 ! cell outer membrane

[Term]
id: GO:0045204
name: MAPK export from nucleus
namespace: biological_process
def: "The directed movement of a MAP kinase from the nucleus to the cytoplasm." [GOC:ebc]
synonym: "cytoplasmic translocation of MAP kinase" EXACT []
synonym: "cytoplasmic translocation of mitogen-activated protein kinase" EXACT []
synonym: "MAPK export from cell nucleus" EXACT []
synonym: "MAPK export out of nucleus" EXACT []
synonym: "MAPK transport from nucleus to cytoplasm" EXACT []
synonym: "MAPK-nucleus export" EXACT []
is_a: GO:0006611 ! protein export from nucleus

[Term]
id: GO:0045205
name: obsolete MAPK transporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the directed movement of MAP kinase into, out of or within a cell, or between cells." [GOC:ebc, GOC:mtg_transport, ISBN:0815340729]
comment: This term was made obsolete because we do not know what it was intended to represent when it was created.
synonym: "MAPK transporter activity" EXACT []
is_obsolete: true

[Term]
id: GO:0045206
name: obsolete MAPK phosphatase transporter activity
namespace: molecular_function
alt_id: GO:0045207
def: "OBSOLETE. Enables the directed movement of MAPK phosphatase into, out of or within a cell, or between cells." [GOC:ebc, GOC:mtg_transport, ISBN:0815340729]
comment: This term was made obsolete because we do not know what it was intended to represent when it was created.
synonym: "leptomycin B-sensitive MAPK phosphatase transporter activity" NARROW []
synonym: "leptomycin B-sensitive MKP shuttle" NARROW []
synonym: "MAPK phosphatase transporter activity" EXACT []
synonym: "MKP shuttle" NARROW []
is_obsolete: true

[Term]
id: GO:0045208
name: MAPK phosphatase export from nucleus
namespace: biological_process
def: "The directed movement of a MAPK phosphatase from the nucleus to the cytoplasm." [GOC:ebc]
synonym: "MAPK phosphatase export from cell nucleus" EXACT []
synonym: "MAPK phosphatase export out of nucleus" EXACT []
synonym: "MAPK phosphatase transport from nucleus to cytoplasm" EXACT []
synonym: "MAPK phosphatase-nucleus export" EXACT []
is_a: GO:0006611 ! protein export from nucleus

[Term]
id: GO:0045209
name: MAPK phosphatase export from nucleus, leptomycin B sensitive
namespace: biological_process
def: "Leptomycin B-sensitive movement of a MAPK phosphatase from the nucleus to the cytoplasm." [GOC:ebc]
synonym: "leptomycin B-sensitive MAPK phosphatase export out of nucleus" EXACT []
synonym: "leptomycin B-sensitive MAPK phosphatase transport from nucleus to cytoplasm" EXACT []
synonym: "leptomycin B-sensitive MAPK phosphatase-nucleus export" EXACT []
synonym: "MAPK phosphatase export from cell nucleus, leptomycin B sensitive" EXACT []
synonym: "MAPK phosphatase export out of nucleus, leptomycin B sensitive" EXACT []
synonym: "MAPK phosphatase transport from nucleus to cytoplasm, leptomycin B sensitive" EXACT []
synonym: "MAPK phosphatase-nucleus export, leptomycin B sensitive" EXACT []
is_a: GO:0045208 ! MAPK phosphatase export from nucleus

[Term]
id: GO:0045210
name: FasL biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of fas ligand (FasL or CD95L), an antigen originally found to be expressed on the cell surface of activated human T-lymphocytes and B-lymphocytes and a variety of malignant human lymphoid cell lines." [http://www.copewithcytokines.de/]
synonym: "APT1LG1 biosynthetic process" EXACT [GOC:add]
synonym: "CD178 biosynthetic process" EXACT [GOC:add]
synonym: "CD95L biosynthesis" EXACT [GOC:add]
synonym: "CD95L biosynthetic process" EXACT [GOC:add]
synonym: "fas ligand biosynthetic process" EXACT [GOC:add, PR:000000095]
synonym: "Fas-L biosynthetic process" EXACT [GOC:add]
synonym: "FasL anabolism" EXACT []
synonym: "FasL biosynthesis" EXACT []
synonym: "FasL formation" EXACT []
synonym: "FasL synthesis" EXACT []
synonym: "FASLG biosynthetic process" EXACT [GOC:add]
is_a: GO:0009101 ! glycoprotein biosynthetic process

[Term]
id: GO:0045211
name: postsynaptic membrane
namespace: cellular_component
def: "A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
subset: goslim_synapse
synonym: "post-synaptic membrane" EXACT []
is_a: GO:0097060 ! synaptic membrane
relationship: part_of GO:0098794 ! postsynapse

[Term]
id: GO:0045212
name: neurotransmitter receptor biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of neurotransmitter receptors." [GOC:ai]
synonym: "neurotransmitter receptor anabolism" EXACT []
synonym: "neurotransmitter receptor biosynthesis" EXACT []
synonym: "neurotransmitter receptor formation" EXACT []
synonym: "neurotransmitter receptor synthesis" EXACT []
is_a: GO:0032800 ! receptor biosynthetic process
is_a: GO:0045213 ! neurotransmitter receptor metabolic process

[Term]
id: GO:0045213
name: neurotransmitter receptor metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving neurotransmitter receptors." [GOC:go_curators]
synonym: "neurotransmitter receptor metabolism" EXACT []
is_a: GO:0043112 ! receptor metabolic process

[Term]
id: GO:0045214
name: sarcomere organization
namespace: biological_process
alt_id: GO:0006938
def: "The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:bf]
synonym: "sarcomere alignment" EXACT []
synonym: "sarcomere organisation" EXACT [GOC:curators]
is_a: GO:0031032 ! actomyosin structure organization
relationship: part_of GO:0030239 ! myofibril assembly

[Term]
id: GO:0045216
name: cell-cell junction organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
synonym: "cell-cell junction assembly and maintenance" EXACT []
synonym: "cell-cell junction biogenesis" RELATED []
synonym: "cell-cell junction organisation" EXACT [GOC:mah]
synonym: "intercellular junction assembly and maintenance" EXACT []
xref: Reactome:REACT_103817 "Cell-cell junction organization, Sus scrofa"
xref: Reactome:REACT_107288 "Cell-cell junction organization, Gallus gallus"
xref: Reactome:REACT_108264 "Cell-cell junction organization, Canis familiaris"
xref: Reactome:REACT_114636 "Cell-cell junction organization, Drosophila melanogaster"
xref: Reactome:REACT_19331 "Cell-cell junction organization, Homo sapiens"
xref: Reactome:REACT_30769 "Cell-cell junction organization, Danio rerio"
xref: Reactome:REACT_81733 "Cell-cell junction organization, Rattus norvegicus"
xref: Reactome:REACT_87932 "Cell-cell junction organization, Mus musculus"
xref: Reactome:REACT_88224 "Cell-cell junction organization, Bos taurus"
xref: Reactome:REACT_94850 "Cell-cell junction organization, Taeniopygia guttata"
xref: Reactome:REACT_95996 "Cell-cell junction organization, Xenopus tropicalis"
is_a: GO:0034330 ! cell junction organization

[Term]
id: GO:0045217
name: cell-cell junction maintenance
namespace: biological_process
def: "The maintenance of junctions between cells." [GOC:ai]
synonym: "intercellular junction maintenance" EXACT []
is_a: GO:0034331 ! cell junction maintenance
is_a: GO:0045216 ! cell-cell junction organization

[Term]
id: GO:0045218
name: zonula adherens maintenance
namespace: biological_process
def: "Maintaining the zonula adherens junction, the cell-cell adherens junction formed near the apex of epithelial cells." [GOC:bf]
is_a: GO:0045217 ! cell-cell junction maintenance

[Term]
id: GO:0045219
name: regulation of FasL biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL." [GOC:go_curators]
synonym: "regulation of FasL anabolism" EXACT []
synonym: "regulation of FasL biosynthesis" EXACT []
synonym: "regulation of FasL formation" EXACT []
synonym: "regulation of FasL synthesis" EXACT []
is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045210 ! FasL biosynthetic process
relationship: regulates GO:0045210 ! FasL biosynthetic process

[Term]
id: GO:0045220
name: positive regulation of FasL biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL." [GOC:go_curators]
synonym: "activation of FasL biosynthetic process" NARROW []
synonym: "positive regulation of FasL anabolism" EXACT []
synonym: "positive regulation of FasL biosynthesis" EXACT []
synonym: "positive regulation of FasL formation" EXACT []
synonym: "positive regulation of FasL synthesis" EXACT []
synonym: "stimulation of FasL biosynthetic process" NARROW []
synonym: "up regulation of FasL biosynthetic process" EXACT []
synonym: "up-regulation of FasL biosynthetic process" EXACT []
synonym: "upregulation of FasL biosynthetic process" EXACT []
is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process
is_a: GO:0045219 ! regulation of FasL biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045210 ! FasL biosynthetic process
relationship: positively_regulates GO:0045210 ! FasL biosynthetic process

[Term]
id: GO:0045221
name: negative regulation of FasL biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL." [GOC:go_curators]
synonym: "down regulation of FasL biosynthetic process" EXACT []
synonym: "down-regulation of FasL biosynthetic process" EXACT []
synonym: "downregulation of FasL biosynthetic process" EXACT []
synonym: "inhibition of FasL biosynthetic process" NARROW []
synonym: "negative regulation of FasL anabolism" EXACT []
synonym: "negative regulation of FasL biosynthesis" EXACT []
synonym: "negative regulation of FasL formation" EXACT []
synonym: "negative regulation of FasL synthesis" EXACT []
is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process
is_a: GO:0045219 ! regulation of FasL biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045210 ! FasL biosynthetic process
relationship: negatively_regulates GO:0045210 ! FasL biosynthetic process

[Term]
id: GO:0045222
name: CD4 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of CD4, a CD marker that occurs on T-helper cells and is involved in MHC class II restricted interactions." [GOC:go_curators, ISBN:0198506732]
synonym: "CD4 anabolism" EXACT []
synonym: "CD4 biosynthesis" EXACT []
synonym: "CD4 formation" EXACT []
synonym: "CD4 synthesis" EXACT []
is_a: GO:0009101 ! glycoprotein biosynthetic process

[Term]
id: GO:0045223
name: regulation of CD4 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4." [GOC:go_curators]
synonym: "regulation of CD4 anabolism" EXACT []
synonym: "regulation of CD4 biosynthesis" EXACT []
synonym: "regulation of CD4 formation" EXACT []
synonym: "regulation of CD4 synthesis" EXACT []
is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045222 ! CD4 biosynthetic process
relationship: regulates GO:0045222 ! CD4 biosynthetic process

[Term]
id: GO:0045224
name: positive regulation of CD4 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4." [GOC:go_curators]
synonym: "activation of CD4 biosynthetic process" NARROW []
synonym: "positive regulation of CD4 anabolism" EXACT []
synonym: "positive regulation of CD4 biosynthesis" EXACT []
synonym: "positive regulation of CD4 formation" EXACT []
synonym: "positive regulation of CD4 synthesis" EXACT []
synonym: "stimulation of CD4 biosynthetic process" NARROW []
synonym: "up regulation of CD4 biosynthetic process" EXACT []
synonym: "up-regulation of CD4 biosynthetic process" EXACT []
synonym: "upregulation of CD4 biosynthetic process" EXACT []
is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process
is_a: GO:0045223 ! regulation of CD4 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045222 ! CD4 biosynthetic process
relationship: positively_regulates GO:0045222 ! CD4 biosynthetic process

[Term]
id: GO:0045225
name: negative regulation of CD4 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4." [GOC:go_curators]
synonym: "down regulation of CD4 biosynthetic process" EXACT []
synonym: "down-regulation of CD4 biosynthetic process" EXACT []
synonym: "downregulation of CD4 biosynthetic process" EXACT []
synonym: "inhibition of CD4 biosynthetic process" NARROW []
synonym: "negative regulation of CD4 anabolism" EXACT []
synonym: "negative regulation of CD4 biosynthesis" EXACT []
synonym: "negative regulation of CD4 formation" EXACT []
synonym: "negative regulation of CD4 synthesis" EXACT []
is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process
is_a: GO:0045223 ! regulation of CD4 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045222 ! CD4 biosynthetic process
relationship: negatively_regulates GO:0045222 ! CD4 biosynthetic process

[Term]
id: GO:0045226
name: extracellular polysaccharide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures." [GOC:ai, GOC:go_curators]
subset: gosubset_prok
synonym: "extracellular polysaccharide anabolism" EXACT []
synonym: "extracellular polysaccharide biosynthesis" EXACT []
synonym: "extracellular polysaccharide formation" EXACT []
synonym: "extracellular polysaccharide synthesis" EXACT []
is_a: GO:0033692 ! cellular polysaccharide biosynthetic process
is_a: GO:0046379 ! extracellular polysaccharide metabolic process

[Term]
id: GO:0045227
name: capsule polysaccharide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of polysaccharides that make up the capsule, a protective structure surrounding some species of bacteria and fungi." [GOC:go_curators]
subset: gosubset_prok
synonym: "capsular polysaccharide biosynthesis" EXACT []
synonym: "capsular polysaccharide biosynthetic process" EXACT []
synonym: "capsule polysaccharide anabolism" EXACT []
synonym: "capsule polysaccharide biosynthesis" EXACT []
synonym: "capsule polysaccharide formation" EXACT []
synonym: "capsule polysaccharide synthesis" EXACT []
is_a: GO:0045226 ! extracellular polysaccharide biosynthetic process
is_a: GO:0045230 ! capsule organization

[Term]
id: GO:0045228
name: slime layer polysaccharide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of polysaccharides in the slime layer, a diffused layer of polysaccharide exterior to the bacterial cell wall." [GOC:go_curators]
subset: gosubset_prok
synonym: "slime layer polysaccharide anabolism" EXACT []
synonym: "slime layer polysaccharide biosynthesis" EXACT []
synonym: "slime layer polysaccharide formation" EXACT []
synonym: "slime layer polysaccharide synthesis" EXACT []
is_a: GO:0045226 ! extracellular polysaccharide biosynthetic process
is_a: GO:0045231 ! slime layer organization

[Term]
id: GO:0045229
name: external encapsulating structure organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of external structures that lie outside the plasma membrane and surround the entire cell." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
subset: goslim_pir
subset: gosubset_prok
synonym: "external encapsulating structure organisation" EXACT [GOC:curators]
synonym: "external encapsulating structure organization and biogenesis" EXACT [GOC:dph, GOC:jl, GOC:mah]
is_a: GO:0016043 ! cellular component organization

[Term]
id: GO:0045230
name: capsule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the capsule, a protective structure surrounding some species of bacteria and fungi." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "capsule organisation" EXACT [GOC:curators]
synonym: "capsule organization and biogenesis" RELATED []
is_a: GO:0045229 ! external encapsulating structure organization

[Term]
id: GO:0045231
name: slime layer organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a slime layer. A slime layer is an easily removed, diffuse, unorganized layer of extracellular material that surrounds a cell." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "slime layer organisation" EXACT [GOC:curators]
synonym: "slime layer organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0045229 ! external encapsulating structure organization

[Term]
id: GO:0045232
name: S-layer organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an S-layer enveloping the cell. The S-layer is a crystalline protein layer surrounding some bacteria." [GOC:ai]
synonym: "S-layer organisation" EXACT [GOC:curators]
synonym: "S-layer organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0045229 ! external encapsulating structure organization

[Term]
id: GO:0045233
name: obsolete natural killer cell receptor activity
namespace: molecular_function
def: "OBSOLETE. A receptor found on the surface of natural killer cells which binds Class I MHC antigens and is required for activation of NK activity. It belongs to the Ly49i family." [GOC:ebc]
comment: This term was made obsolete because the receptor is defined based on its cellular expression pattern, and the definition is inaccurate: receptors on natural killer cells can either activate or inhibit natural killer (NK) cell-mediated cytotoxicity.
synonym: "Ly49i" NARROW []
synonym: "natural killer cell receptor activity" EXACT []
synonym: "NK cell receptor activity" EXACT []
is_obsolete: true
consider: GO:0002769
consider: GO:0004888
consider: GO:0030101

[Term]
id: GO:0045234
name: protein palmitoleylation
namespace: biological_process
alt_id: GO:0045235
def: "The covalent attachment of a palmitoleyl group to a protein." [GOC:ai]
subset: gosubset_prok
synonym: "protein amino acid palmitoleylation" EXACT [GOC:bf]
is_a: GO:0006497 ! protein lipidation
is_a: GO:0043543 ! protein acylation

[Term]
id: GO:0045236
name: CXCR chemokine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a chemokine receptor in the CXCR family." [GOC:ceb, PMID:11910892]
synonym: "alpha chemokine receptor binding" EXACT []
synonym: "alpha chemokine receptor ligand" NARROW []
synonym: "C-X-C chemokine receptor ligand" NARROW []
synonym: "CXC chemokine receptor ligand" NARROW []
is_a: GO:0042379 ! chemokine receptor binding

[Term]
id: GO:0045237
name: CXCR1 chemokine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the CXCR1 chemokine receptor." [GOC:ceb, PMID:11910892]
synonym: "CXCR1 chemokine receptor ligand" NARROW []
is_a: GO:0005153 ! interleukin-8 receptor binding

[Term]
id: GO:0045238
name: CXCR2 chemokine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the CXCR2 chemokine receptor." [GOC:ceb, PMID:11910892]
synonym: "CXCR2 chemokine receptor ligand" NARROW []
is_a: GO:0005153 ! interleukin-8 receptor binding

[Term]
id: GO:0045239
name: tricarboxylic acid cycle enzyme complex
namespace: cellular_component
def: "Any of the heteromeric enzymes that act in the TCA cycle." [GOC:mah]
subset: goslim_pir
subset: gosubset_prok
synonym: "TCA cycle enzyme complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0045240
name: dihydrolipoyl dehydrogenase complex
namespace: cellular_component
def: "A protein complex that possesses alpha-ketoglutarate dehydrogenase activity." [GOC:mah]
subset: gosubset_prok
synonym: "2-oxoglutarate dehydrogenase complex" EXACT []
synonym: "alpha-ketoglutarate dehydrogenase complex" EXACT []
is_a: GO:0045239 ! tricarboxylic acid cycle enzyme complex
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:0045241
name: cytosolic alpha-ketoglutarate dehydrogenase complex
namespace: cellular_component
def: "Cytosolic complex that possesses alpha-ketoglutarate dehydrogenase activity." [GOC:mah, GOC:mtg_sensu]
subset: gosubset_prok
synonym: "2-oxoglutarate dehydrogenase complex" BROAD []
is_a: GO:0045240 ! dihydrolipoyl dehydrogenase complex
is_a: GO:0045246 ! cytosolic tricarboxylic acid cycle enzyme complex

[Term]
id: GO:0045242
name: isocitrate dehydrogenase complex (NAD+)
namespace: cellular_component
def: "Complex that possesses isocitrate dehydrogenase (NAD+) activity." [GOC:mah]
subset: gosubset_prok
is_a: GO:0045239 ! tricarboxylic acid cycle enzyme complex
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:0045243
name: cytosolic isocitrate dehydrogenase complex (NAD+)
namespace: cellular_component
def: "Cytosolic complex that possesses isocitrate dehydrogenase (NAD+) activity." [GOC:mah, GOC:mtg_sensu]
subset: gosubset_prok
synonym: "isocitrate dehydrogenase complex (NAD+)" BROAD []
is_a: GO:0045242 ! isocitrate dehydrogenase complex (NAD+)
is_a: GO:0045246 ! cytosolic tricarboxylic acid cycle enzyme complex
intersection_of: GO:0045242 ! isocitrate dehydrogenase complex (NAD+)
intersection_of: part_of GO:0005829 ! cytosol
relationship: part_of GO:0005829 ! cytosol

[Term]
id: GO:0045244
name: succinate-CoA ligase complex (GDP-forming)
namespace: cellular_component
alt_id: GO:0008325
alt_id: GO:0045245
def: "A heterodimeric enzyme complex, usually composed of an alpha and beta chain. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming GTP." [EC:6.2.1.4, GOC:jl]
synonym: "succinyl-CoA synthetase, GDP-forming" EXACT [CORUM:392]
is_a: GO:0030062 ! mitochondrial tricarboxylic acid cycle enzyme complex
is_a: GO:0042709 ! succinate-CoA ligase complex
relationship: part_of GO:0005739 ! mitochondrion

[Term]
id: GO:0045246
name: cytosolic tricarboxylic acid cycle enzyme complex
namespace: cellular_component
def: "Any of the heteromeric enzymes, located in the cytosol, that act in the tricarboxylic acid (TCA) cycle." [GOC:mah, GOC:mtg_sensu]
subset: gosubset_prok
synonym: "TCA cycle enzyme complex" BROAD []
synonym: "tricarboxylic acid cycle enzyme complex" BROAD []
is_a: GO:0044445 ! cytosolic part
is_a: GO:0045239 ! tricarboxylic acid cycle enzyme complex

[Term]
id: GO:0045247
name: cytosolic electron transfer flavoprotein complex
namespace: cellular_component
def: "A protein complex located in the cytosol containing flavin adenine dinucleotide (FAD) that, together with an acyl-CoA dehydrogenase, forms a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors." [GOC:mtg_sensu, ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0044445 ! cytosolic part
is_a: GO:0045251 ! electron transfer flavoprotein complex

[Term]
id: GO:0045248
name: cytosolic oxoglutarate dehydrogenase complex
namespace: cellular_component
def: "A cytosolic complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2)." [GOC:mtg_sensu, PMID:10848975]
comment: See also the molecular functions term 'oxoglutarate dehydrogenase (succinyl-transferring) activity ; GO:0004591', 'dihydrolipoyllysine-residue succinyltransferase activity ; GO:0004149' and 'dihydrolipoyl dehydrogenase activity ; GO:0004148'.
subset: gosubset_prok
is_a: GO:0044445 ! cytosolic part
is_a: GO:0045252 ! oxoglutarate dehydrogenase complex
intersection_of: GO:0045252 ! oxoglutarate dehydrogenase complex
intersection_of: part_of GO:0005829 ! cytosol
relationship: part_of GO:0005829 ! cytosol

[Term]
id: GO:0045249
name: cytosol pyruvate dehydrogenase (lipoamide) phosphatase complex
namespace: cellular_component
def: "A cytosolic complex of a regulatory and catalytic subunit that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex." [GOC:mtg_sensu, PMID:9395502]
comment: See also the cellular component term 'cytosolic pyruvate dehydrogenase complex ; GO:0045250'.
subset: gosubset_prok
is_a: GO:0044445 ! cytosolic part
is_a: GO:0045253 ! pyruvate dehydrogenase (lipoamide) phosphatase complex
intersection_of: GO:0045253 ! pyruvate dehydrogenase (lipoamide) phosphatase complex
intersection_of: part_of GO:0005829 ! cytosol
relationship: part_of GO:0005829 ! cytosol

[Term]
id: GO:0045250
name: cytosolic pyruvate dehydrogenase complex
namespace: cellular_component
def: "Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains fewer subunits than its eukaryotic counterpart; for example, the E. coli complex contains 12 E1 dimers, 8 E2 trimers, and 6 E3 dimers arranged in highly symmetric cubic order." [GOC:mtg_sensu, ISBN:0471331309, ISBN:0716720094]
comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The functions of this complex are represented by the molecular function terms 'pyruvate dehydrogenase (lipoamide) activity ; GO:0004739', 'dihydrolipoamide S-acetyltransferase activity ; GO:0004742', and 'dihydrolipoamide dehydrogenase activity ; GO:0004148'.
subset: gosubset_prok
synonym: "pyruvate dehydrogenase complex (lipoamide)" RELATED []
is_a: GO:0044445 ! cytosolic part
is_a: GO:0045254 ! pyruvate dehydrogenase complex
intersection_of: GO:0045254 ! pyruvate dehydrogenase complex
intersection_of: part_of GO:0005829 ! cytosol
relationship: part_of GO:0005829 ! cytosol

[Term]
id: GO:0045251
name: electron transfer flavoprotein complex
namespace: cellular_component
def: "A protein complex containing flavin adenine dinucleotide (FAD) and acyl-CoA dehydrogenase, which form a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors in the mitochondrial electron transport system." [ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0045252
name: oxoglutarate dehydrogenase complex
namespace: cellular_component
def: "A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2)." [MetaCyc:CPLX66-42, PMID:10848975]
comment: See also the molecular functions term 'oxoglutarate dehydrogenase (succinyl-transferring) activity ; GO:0004591', 'dihydrolipoyllysine-residue succinyltransferase activity ; GO:0004149' and 'dihydrolipoyl dehydrogenase activity ; GO:0004148'.
subset: goslim_pir
subset: gosubset_prok
synonym: "dihydrolipoamide S-succinyltransferase complex" EXACT []
is_a: GO:0045240 ! dihydrolipoyl dehydrogenase complex
is_a: GO:1990234 ! transferase complex

[Term]
id: GO:0045253
name: pyruvate dehydrogenase (lipoamide) phosphatase complex
namespace: cellular_component
def: "A complex of a regulatory and catalytic subunit that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex." [PMID:9395502]
comment: See also the cellular component term 'cytosolic pyruvate dehydrogenase complex ; GO:0045250'.
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:1903293 ! phosphatase complex

[Term]
id: GO:0045254
name: pyruvate dehydrogenase complex
namespace: cellular_component
alt_id: GO:0009364
def: "Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3)." [ISBN:0716720094]
comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The functions of this complex are represented by the molecular function terms 'pyruvate dehydrogenase (lipoamide) activity ; GO:0004739', 'dihydrolipoamide S-acetyltransferase activity ; GO:0004742', and 'dihydrolipoamide dehydrogenase activity ; GO:0004148'.
subset: goslim_pir
subset: gosubset_prok
synonym: "dihydrolipoyl dehydrogenase complex" BROAD []
synonym: "pyruvate dehydrogenase complex (lipoamide)" EXACT []
xref: Wikipedia:Pyruvate_dehydrogenase_complex
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:1990204 ! oxidoreductase complex

[Term]
id: GO:0045257
name: succinate dehydrogenase complex (ubiquinone)
namespace: cellular_component
def: "The enzyme that catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol; involved in aerobic respiration, repressed in anaerobic respiration." [GOC:kd, ISBN:0198547684]
subset: gosubset_prok
is_a: GO:0045281 ! succinate dehydrogenase complex

[Term]
id: GO:0045258
name: plasma membrane succinate dehydrogenase complex (ubiquinone)
namespace: cellular_component
def: "The enzyme, located in the plasma membrane, that catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol; involved in aerobic respiration, repressed in anaerobic respiration." [GOC:kd, GOC:mtg_sensu, ISBN:0198547684]
subset: gosubset_prok
is_a: GO:0045257 ! succinate dehydrogenase complex (ubiquinone)
is_a: GO:0045282 ! plasma membrane succinate dehydrogenase complex
intersection_of: GO:0045257 ! succinate dehydrogenase complex (ubiquinone)
intersection_of: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0005886 ! plasma membrane

[Term]
id: GO:0045259
name: proton-transporting ATP synthase complex
namespace: cellular_component
alt_id: GO:0045255
def: "A proton-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP during oxidative phosphorylation. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism; the extramembrane sector (containing 3 a and 3 b subunits) is connected via the d-subunit to the membrane sector by several smaller subunits. Within this complex, the g and e subunits and the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. This movement is driven by the hydrogen ion electrochemical potential gradient." [EC:3.6.3.14, ISBN:0198547684, ISBN:0716743663]
subset: gosubset_prok
synonym: "hydrogen-translocating F-type ATPase complex" EXACT []
synonym: "hydrogen-transporting ATP synthase complex" EXACT []
synonym: "proton-transporting F-type ATPase complex" RELATED []
is_a: GO:0016469 ! proton-transporting two-sector ATPase complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0045260
name: plasma membrane proton-transporting ATP synthase complex
namespace: cellular_component
alt_id: GO:0045256
def: "A proton-transporting ATP synthase complex found in the plasma membrane. Examples of this component are found in Bacterial species." [GOC:mah, GOC:mtg_sensu, ISBN:0198547684]
subset: gosubset_prok
synonym: "hydrogen-translocating F-type ATPase complex" BROAD []
synonym: "hydrogen-transporting ATP synthase" EXACT []
synonym: "plasma membrane hydrogen-translocating F-type ATPase complex" EXACT []
synonym: "proton-transporting ATP synthase complex" BROAD []
is_a: GO:0045259 ! proton-transporting ATP synthase complex
is_a: GO:0098797 ! plasma membrane protein complex
intersection_of: GO:0045259 ! proton-transporting ATP synthase complex
intersection_of: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0005886 ! plasma membrane

[Term]
id: GO:0045261
name: proton-transporting ATP synthase complex, catalytic core F(1)
namespace: cellular_component
def: "The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled." [GOC:mah, PMID:10838056]
subset: gosubset_prok
synonym: "hydrogen-transporting ATP synthase, F1 sector" EXACT []
is_a: GO:0033178 ! proton-transporting two-sector ATPase complex, catalytic domain
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0045259 ! proton-transporting ATP synthase complex

[Term]
id: GO:0045262
name: plasma membrane proton-transporting ATP synthase complex, catalytic core F(1)
namespace: cellular_component
def: "The catalytic sector of the plasma membrane hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the plasma membrane when the entire ATP synthase is assembled. Examples of this component are found in Bacterial species." [GOC:mah, GOC:mtg_sensu, PMID:10838056]
comment: See also the cellular component term 'plasma membrane ; GO:0005886'.
subset: gosubset_prok
synonym: "hydrogen-transporting ATP synthase, F1 sector" BROAD []
synonym: "proton-transporting ATP synthase complex, catalytic core F(1)" BROAD []
is_a: GO:0045261 ! proton-transporting ATP synthase complex, catalytic core F(1)
is_a: GO:0098797 ! plasma membrane protein complex
intersection_of: GO:0045261 ! proton-transporting ATP synthase complex, catalytic core F(1)
intersection_of: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0045260 ! plasma membrane proton-transporting ATP synthase complex

[Term]
id: GO:0045263
name: proton-transporting ATP synthase complex, coupling factor F(o)
namespace: cellular_component
def: "All non-F1 subunits of a hydrogen-transporting ATP synthase, including integral and peripheral membrane proteins." [PMID:10838056]
subset: gosubset_prok
synonym: "hydrogen-transporting ATP synthase complex, coupling factor F(o)" EXACT [GOC:mah]
synonym: "hydrogen-transporting ATP synthase, coupling factor CF(0)" NARROW []
synonym: "hydrogen-transporting ATP synthase, F0 sector" EXACT []
synonym: "proton-transporting ATP synthase complex, coupling factor F(0)" EXACT []
is_a: GO:0033177 ! proton-transporting two-sector ATPase complex, proton-transporting domain
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0045259 ! proton-transporting ATP synthase complex

[Term]
id: GO:0045264
name: plasma membrane proton-transporting ATP synthase complex, coupling factor F(o)
namespace: cellular_component
def: "All non-F1 subunits of the plasma membrane hydrogen-transporting ATP synthase, including integral and peripheral plasma membrane proteins." [GOC:mah, GOC:mtg_sensu, PMID:10838056]
subset: gosubset_prok
synonym: "hydrogen-transporting ATP synthase, F0 sector" BROAD []
synonym: "proton-transporting ATP synthase complex, coupling factor F(0)" BROAD []
synonym: "proton-transporting ATP synthase complex, coupling factor F(o)" BROAD []
is_a: GO:0045263 ! proton-transporting ATP synthase complex, coupling factor F(o)
is_a: GO:0098797 ! plasma membrane protein complex
intersection_of: GO:0045263 ! proton-transporting ATP synthase complex, coupling factor F(o)
intersection_of: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0045260 ! plasma membrane proton-transporting ATP synthase complex

[Term]
id: GO:0045265
name: proton-transporting ATP synthase, stator stalk
namespace: cellular_component
def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the membrane-associated Fo proteins; is thought to prevent futile rotation of the catalytic core." [PMID:10838056]
subset: gosubset_prok
synonym: "hydrogen-transporting ATP synthase, stator stalk" EXACT []
is_a: GO:0044424 ! intracellular part
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0045263 ! proton-transporting ATP synthase complex, coupling factor F(o)

[Term]
id: GO:0045266
name: plasma membrane proton-transporting ATP synthase, stator stalk
namespace: cellular_component
def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the plasma membrane-associated F0 proteins; is thought to prevent futile rotation of the catalytic core. Examples of this component are found in Bacterial species." [GOC:mtg_sensu, PMID:10838056]
subset: gosubset_prok
synonym: "hydrogen-transporting ATP synthase, stator stalk" BROAD []
synonym: "proton-transporting ATP synthase, stator stalk" BROAD []
is_a: GO:0045265 ! proton-transporting ATP synthase, stator stalk
is_a: GO:0098797 ! plasma membrane protein complex
intersection_of: GO:0045265 ! proton-transporting ATP synthase, stator stalk
intersection_of: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0045264 ! plasma membrane proton-transporting ATP synthase complex, coupling factor F(o)

[Term]
id: GO:0045267
name: proton-transporting ATP synthase, catalytic core
namespace: cellular_component
def: "The hexamer that possesses the catalytic activity of the mitochondrial hydrogen-transporting ATP synthase." [PMID:10838056]
subset: gosubset_prok
synonym: "hydrogen-transporting ATP synthase, catalytic core" EXACT []
is_a: GO:0044424 ! intracellular part
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0045261 ! proton-transporting ATP synthase complex, catalytic core F(1)

[Term]
id: GO:0045268
name: plasma membrane proton-transporting ATP synthase, catalytic core
namespace: cellular_component
def: "The hexamer that possesses the catalytic activity of the plasma membrane hydrogen-transporting ATP synthase. Examples of this component are found in Bacterial species." [GOC:mtg_sensu, PMID:10838056]
subset: gosubset_prok
synonym: "hydrogen-transporting ATP synthase, catalytic core" BROAD []
synonym: "proton-transporting ATP synthase, catalytic core" BROAD []
is_a: GO:0045267 ! proton-transporting ATP synthase, catalytic core
is_a: GO:0098797 ! plasma membrane protein complex
intersection_of: GO:0045267 ! proton-transporting ATP synthase, catalytic core
intersection_of: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0045262 ! plasma membrane proton-transporting ATP synthase complex, catalytic core F(1)

[Term]
id: GO:0045269
name: proton-transporting ATP synthase, central stalk
namespace: cellular_component
def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the membrane-associated Fo proteins; rotates within the catalytic core during catalysis." [PMID:10838056]
subset: gosubset_prok
synonym: "hydrogen-transporting ATP synthase, central stalk" EXACT []
is_a: GO:0044424 ! intracellular part
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0045261 ! proton-transporting ATP synthase complex, catalytic core F(1)

[Term]
id: GO:0045270
name: plasma membrane proton-transporting ATP synthase, central stalk
namespace: cellular_component
def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the plasma membrane-associated Fo proteins; rotates within the catalytic core during catalysis. Examples of this component are found in Bacterial species." [GOC:mtg_sensu, PMID:10838056]
subset: gosubset_prok
synonym: "hydrogen-transporting ATP synthase, central stalk" BROAD []
synonym: "proton-transporting ATP synthase, central stalk" BROAD []
is_a: GO:0045269 ! proton-transporting ATP synthase, central stalk
is_a: GO:0098797 ! plasma membrane protein complex
intersection_of: GO:0045269 ! proton-transporting ATP synthase, central stalk
intersection_of: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0045262 ! plasma membrane proton-transporting ATP synthase complex, catalytic core F(1)

[Term]
id: GO:0045271
name: respiratory chain complex I
namespace: cellular_component
alt_id: GO:0045279
def: "Respiratory chain complex I is an enzyme of the respiratory chain. It consists of several polypeptide chains and is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix. The electrons of NADH enter the chain at this complex." [GOC:imk, GOC:jid, ISBN:0716749556]
comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'NADH dehydrogenase (ubiquinone) activity ; GO:0008137'.
subset: gosubset_prok
synonym: "electron transport complex I" RELATED []
synonym: "NADH dehydrogenase (ubiquinone) complex" EXACT []
synonym: "NADH dehydrogenase complex (ubiquinone)" EXACT []
synonym: "NADH-Q oxidoreductase complex" EXACT []
is_a: GO:0030964 ! NADH dehydrogenase complex
is_a: GO:0098803 ! respiratory chain complex
relationship: part_of GO:0070469 ! respiratory chain

[Term]
id: GO:0045272
name: plasma membrane respiratory chain complex I
namespace: cellular_component
def: "A subcomplex of the respiratory chain located in the plasma membrane. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone. Examples of this component are found in bacterial species." [GOC:mtg_sensu, ISBN:0198547684]
subset: gosubset_prok
synonym: "NADH dehydrogenase (ubiquinone) complex" BROAD []
synonym: "respiratory chain complex I" BROAD []
is_a: GO:0045271 ! respiratory chain complex I
is_a: GO:0098797 ! plasma membrane protein complex
intersection_of: GO:0045271 ! respiratory chain complex I
intersection_of: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0070470 ! plasma membrane respiratory chain

[Term]
id: GO:0045273
name: respiratory chain complex II
namespace: cellular_component
def: "A part of the respiratory chain, containing the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain." [ISBN:0198547684]
subset: goslim_pir
subset: gosubset_prok
synonym: "electron transport complex II" RELATED []
is_a: GO:0044424 ! intracellular part
is_a: GO:0098803 ! respiratory chain complex
relationship: part_of GO:0070469 ! respiratory chain

[Term]
id: GO:0045274
name: plasma membrane respiratory chain complex II
namespace: cellular_component
def: "A part of the respiratory chain located in the plasma membrane, containing the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain. Examples of this component are found in bacterial species." [GOC:mtg_sensu, ISBN:0198547684]
subset: gosubset_prok
synonym: "respiratory chain complex II" BROAD []
is_a: GO:0045273 ! respiratory chain complex II
is_a: GO:0098797 ! plasma membrane protein complex
intersection_of: GO:0045273 ! respiratory chain complex II
intersection_of: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0070470 ! plasma membrane respiratory chain

[Term]
id: GO:0045275
name: respiratory chain complex III
namespace: cellular_component
alt_id: GO:0032842
alt_id: GO:0045285
def: "A protein complex that transfers electrons from ubiquinol to cytochrome c and translocates two protons across a membrane. The complex contains a core structure of three catalytic subunits: cytochrome b, the Rieske iron sulfur protein (ISP), and cytochrome c1, which are arranged in an integral membrane-bound dimeric complex; additional subunits are present, and vary among different species." [PMID:16228398, PMID:16352458, PMID:17200733]
subset: goslim_pir
subset: gosubset_prok
synonym: "complex III" EXACT []
synonym: "CoQH2-cytochrome c reductase complex" RELATED []
synonym: "cytochrome bc(1) complex" EXACT []
synonym: "cytochrome bc1 complex" EXACT []
synonym: "electron transport complex III" RELATED []
synonym: "ubiquinol-cytochrome c oxidoreductase complex" EXACT []
synonym: "ubiquinol-cytochrome-c reductase complex" EXACT []
xref: Wikipedia:Coenzyme_Q_-_cytochrome_c_reductase
is_a: GO:0044424 ! intracellular part
is_a: GO:0070069 ! cytochrome complex
is_a: GO:0098803 ! respiratory chain complex
is_a: GO:1902495 ! transmembrane transporter complex
is_a: GO:1990204 ! oxidoreductase complex
relationship: part_of GO:0070469 ! respiratory chain

[Term]
id: GO:0045276
name: plasma membrane respiratory chain complex III
namespace: cellular_component
alt_id: GO:0045286
def: "A part of the respiratory chain located in the plasma membrane, containing about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1. Examples of this component are found in bacterial species." [GOC:mtg_sensu, ISBN:0198547684]
subset: gosubset_prok
synonym: "plasma membrane ubiquinol-cytochrome-c reductase complex" EXACT []
synonym: "respiratory chain complex III" BROAD []
synonym: "ubiquinol-cytochrome c oxidoreductase complex" BROAD []
synonym: "ubiquinol-cytochrome-c reductase complex" BROAD []
is_a: GO:0045275 ! respiratory chain complex III
is_a: GO:0098797 ! plasma membrane protein complex
intersection_of: GO:0045275 ! respiratory chain complex III
intersection_of: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0070470 ! plasma membrane respiratory chain

[Term]
id: GO:0045277
name: respiratory chain complex IV
namespace: cellular_component
alt_id: GO:0045287
def: "A part of the respiratory chain, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2)." [ISBN:0198547684]
subset: goslim_pir
subset: gosubset_prok
synonym: "cytochrome c oxidase complex" EXACT []
synonym: "electron transport complex IV" RELATED []
is_a: GO:0044424 ! intracellular part
is_a: GO:0070069 ! cytochrome complex
is_a: GO:0098803 ! respiratory chain complex
relationship: part_of GO:0070469 ! respiratory chain

[Term]
id: GO:0045278
name: plasma membrane respiratory chain complex IV
namespace: cellular_component
alt_id: GO:0045288
def: "A part of the respiratory chain located in the plasma membrane, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2). Examples of this component are found in bacterial species." [GOC:mtg_sensu, ISBN:0198547684]
subset: gosubset_prok
synonym: "cytochrome c oxidase complex" BROAD []
synonym: "respiratory chain complex IV" BROAD []
is_a: GO:0045277 ! respiratory chain complex IV
is_a: GO:0098797 ! plasma membrane protein complex
intersection_of: GO:0045277 ! respiratory chain complex IV
intersection_of: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0070470 ! plasma membrane respiratory chain

[Term]
id: GO:0045281
name: succinate dehydrogenase complex
namespace: cellular_component
def: "A multimeric complex which consists of flavoprotein (subunit A ; InterPro:IPR003952), iron-sulfur protein (subunit B) and membrane-bound cytochrome b560 (subunit C; InterPro:IPR000701). In some Archaea, the membrane-bound subunits (C or C and D) do not necessarily contain heme. Membrane-bound subunits can bind or react with quinones." [GOC:kd, InterPro:IPR000701]
subset: gosubset_prok
is_a: GO:0044424 ! intracellular part
is_a: GO:0098803 ! respiratory chain complex
is_a: GO:1990204 ! oxidoreductase complex
relationship: part_of GO:0045273 ! respiratory chain complex II

[Term]
id: GO:0045282
name: plasma membrane succinate dehydrogenase complex
namespace: cellular_component
def: "A multimeric complex which consists of flavoprotein (subunit A ; InterPro:IPR003952), iron-sulfur protein (subunit B) and membrane-bound cytochrome b560 (subunit C; InterPro:IPR000701). In some Archaea, the membrane-bound subunits (C or C and D) do not necessarily contain heme. Membrane-bound subunits can bind/react with quinones. Examples of this component are found in Bacterial species." [GOC:kd, GOC:mtg_sensu, InterPro:IPR000701]
subset: gosubset_prok
synonym: "succinate dehydrogenase complex" BROAD []
is_a: GO:0045281 ! succinate dehydrogenase complex
is_a: GO:0098797 ! plasma membrane protein complex
intersection_of: GO:0045281 ! succinate dehydrogenase complex
intersection_of: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0045274 ! plasma membrane respiratory chain complex II

[Term]
id: GO:0045283
name: fumarate reductase complex
namespace: cellular_component
def: "A membrane-bound flavoenzyme complex consisting of four subunits, A, B, C, and D. A and B comprise the membrane-extrinsic catalytic domain and C (InterPro:IPR003510; InterPro:IPR004224) and D (InterPro:IPR003418) link the catalytic centers to the electron-transport chain. This family consists of the 13 kDa hydrophobic subunit D. This component may be required to anchor the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. Fumarate reductase couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, in a reaction opposite to that catalyzed by the related complex II of the respiratory chain (succinate dehydrogenase-(ubiquinone))." [InterPro:IPR003418, InterPro:IPR004224]
comment: See also the molecular function term 'succinate dehydrogenase (ubiquinone) activity ; GO:0008177'.
subset: gosubset_prok
is_a: GO:0044424 ! intracellular part
is_a: GO:0098803 ! respiratory chain complex
relationship: part_of GO:0045273 ! respiratory chain complex II

[Term]
id: GO:0045284
name: plasma membrane fumarate reductase complex
namespace: cellular_component
def: "A membrane-bound flavoenzyme complex consisting of four subunits, A, B, C, and D. A and B comprise the membrane-extrinsic catalytic domain and C (InterPro:IPR003510; InterPro:IPR00224) and D (InterPro:IPR003418) link the catalytic centers to the electron-transport chain. In some species, the complex has only three subunits, and in these cases, there is only one membrane anchor instead of two. This family consists of the 13 kDa hydrophobic subunit D. This component may be required to anchor the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. Fumarate reductase couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, in a reaction opposite to that catalyzed by the related complex II of the respiratory chain (succinate dehydrogenase-(ubiquinone)). Examples of this component are found in bacterial species." [GOC:mtg_sensu, InterPro:IPR003418, InterPro:IPR004224]
comment: See also the molecular function term 'succinate dehydrogenase (ubiquinone) activity ; GO:0008177'.
subset: gosubset_prok
synonym: "fumarate reductase complex" BROAD []
is_a: GO:0045283 ! fumarate reductase complex
is_a: GO:0098797 ! plasma membrane protein complex
intersection_of: GO:0045283 ! fumarate reductase complex
intersection_of: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0045274 ! plasma membrane respiratory chain complex II

[Term]
id: GO:0045289
name: luciferin monooxygenase activity
namespace: molecular_function
def: "Catalysis of the generalized reaction: luciferin + O2 = oxidized luciferin + CO2 + light. There may be additional substrates and reactants involved in the reaction. The reaction results in light emission as luciferin returns to the ground state after enzymatic oxidation." [GOC:bf]
synonym: "luciferase activity" EXACT []
synonym: "luciferase monooxygenase activity" RELATED []
is_a: GO:0004497 ! monooxygenase activity

[Term]
id: GO:0045290
name: D-arabinose 1-dehydrogenase [NAD(P)+] activity
namespace: molecular_function
def: "Catalysis of the reaction: D-arabinose + NAD(P)+ = D-arabinono-1,4-lactone + NAD(P)H + H+." [EC:1.1.1.117]
synonym: "D-arabinose:NAD(P)+ 1-oxidoreductase activity" EXACT [EC:1.1.1.117]
xref: EC:1.1.1.117
xref: MetaCyc:1.1.1.117-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0045291
name: mRNA trans splicing, SL addition
namespace: biological_process
def: "The joining together of two independently transcribed RNAs, where the one that provides the 5' portion of the final mRNA is from a splice leader RNA (SL-RNA). The SL-RNA, or mini-exon donor sequence, is added to the 5'-end of the acceptor RNA molecule which provides the mRNA body." [GOC:krc, ISBN:0879695897, PMID:2675423]
synonym: "nuclear mRNA trans splicing, SL addition" EXACT [GOC:vw]
synonym: "nuclear mRNA trans splicing, spliced leader addition" EXACT []
is_a: GO:0000365 ! mRNA trans splicing, via spliceosome

[Term]
id: GO:0045292
name: mRNA cis splicing, via spliceosome
namespace: biological_process
def: "The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript." [GOC:krc, http://calspace.ucsd.edu/origins/Glossary/C.htm, ISBN:0879695897]
synonym: "nuclear mRNA cis splicing, via spliceosome" EXACT [GOC:vw]
synonym: "nuclear mRNA cis splicing, via U2-type spliceosome" NARROW []
synonym: "splicing" BROAD [GOC:vw]
is_a: GO:0000398 ! mRNA splicing, via spliceosome

[Term]
id: GO:0045293
name: mRNA editing complex
namespace: cellular_component
def: "A protein complex that posttranscriptionally catalyzes insertion, deletion or substitution of nucleotides at multiple sites within nascent mRNA transcripts to produce mature mRNAs in eukaryotes." [http://www.ejbiotechnology.info/content/vol1/issue1/full/4/, PMID:11564867, PMID:12139607]
subset: goslim_pir
synonym: "editosome" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0045294
name: alpha-catenin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the alpha subunit of the catenin complex." [GOC:bf]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0045295
name: gamma-catenin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the gamma subunit of the catenin complex." [GOC:bf]
synonym: "plakoglobin binding" EXACT [GOC:BHF]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0045296
name: cadherin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf]
is_a: GO:0050839 ! cell adhesion molecule binding

[Term]
id: GO:0045297
name: post-mating behavior
namespace: biological_process
def: "The specific behavior of an organism following mating." [GOC:bf, GOC:pr]
synonym: "post-mating behaviour" EXACT []
is_a: GO:0019098 ! reproductive behavior

[Term]
id: GO:0045298
name: tubulin complex
namespace: cellular_component
def: "A heterodimer of tubulins alpha and beta that constitutes the protomer for microtubule assembly." [ISBN:0716731363]
is_a: GO:0043234 ! protein complex
is_a: GO:0044430 ! cytoskeletal part

[Term]
id: GO:0045299
name: otolith mineralization
namespace: biological_process
def: "The precipitation of specific crystal forms of calcium carbonate with extracellular matrix proteins in the otolith organs of the vertebrate inner ear." [GOC:dsf, PMID:15581873]
is_a: GO:0031214 ! biomineral tissue development
relationship: part_of GO:0048840 ! otolith development

[Term]
id: GO:0045300
name: acyl-[acyl-carrier-protein] desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: stearoyl-[acyl-carrier protein] + reduced acceptor + O2 = oleoyl-[acyl-carrier protein] + acceptor + H2O. The enzyme requires ferredoxin." [EC:1.14.19.2]
comment: Note that this function was formerly EC:1.14.99.6.
subset: gosubset_prok
synonym: "acyl-[acyl-carrier protein] desaturase activity" EXACT []
synonym: "acyl-acyl-carrier-protein desaturase activity" EXACT [EC:1.14.19.2]
synonym: "acyl-acyl-carrier-protein, hydrogen-donor:oxygen oxidoreductase activity" EXACT [EC:1.14.19.2]
synonym: "stearyl acyl carrier protein desaturase activity" EXACT [EC:1.14.19.2]
synonym: "stearyl-ACP desaturase activity" EXACT [EC:1.14.19.2]
xref: EC:1.14.19.2
xref: MetaCyc:1.14.19.2-RXN
xref: MetaCyc:PWY-5147
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

[Term]
id: GO:0045301
name: tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine)-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: tRNA-(2-methylthio-N-6-isopentenyl adenosine) = tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine) + O2. 2-methylthio-N-6-isopentenyl adenosine is also known as ms2i6A; 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine is also known as ms2io6A and 2-methylthio-cis-ribozeatin." [GOC:mlg, PMID:8253666]
subset: gosubset_prok
synonym: "2-methylthio-cis-ribozeatin hydroxylase activity" EXACT []
synonym: "tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyladenosine)-hydroxylase activity" EXACT []
synonym: "tRNA-(ms2io6A)-hydroxylase activity" EXACT []
is_a: GO:0016491 ! oxidoreductase activity
relationship: part_of GO:0002195 ! 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine-tRNA biosynthesis

[Term]
id: GO:0045302
name: choloylglycine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholan-24-oylglycine + H2O = 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanate + glycine." [EC:3.5.1.24]
subset: gosubset_prok
synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oylglycine amidohydrolase activity" EXACT [EC:3.5.1.24]
synonym: "bile salt hydrolase activity" EXACT [EC:3.5.1.24]
synonym: "choloyltaurine hydrolase activity" EXACT [EC:3.5.1.24]
synonym: "glycocholase activity" EXACT [EC:3.5.1.24]
xref: EC:3.5.1.24
xref: MetaCyc:CHOLOYLGLYCINE-HYDROLASE-RXN
xref: RHEA:19356
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0045303
name: diaminobutyrate-2-oxoglutarate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + L-2,4-diaminobutyrate = L-aspartate 4-semialdehyde + L-glutamate." [EC:2.6.1.76, RHEA:11163]
subset: gosubset_prok
synonym: "2,4-diaminobutyrate 4-aminotransferase activity" EXACT [EC:2.6.1.76]
synonym: "DAB aminotransferase activity" EXACT [EC:2.6.1.76]
synonym: "DABA aminotransferase activity" EXACT [EC:2.6.1.76]
synonym: "diaminibutyric acid aminotransferase activity" EXACT [EC:2.6.1.76]
synonym: "diaminobutyrate transaminase activity" EXACT [EC:2.6.1.76]
synonym: "diaminobutyrate--2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.76]
synonym: "EctB" RELATED [EC:2.6.1.76]
synonym: "L-2,4-diaminobutanoate:2-oxoglutarate 4-aminotransferase activity" EXACT [EC:2.6.1.76]
synonym: "L-2,4-diaminobutyrate:2-ketoglutarate 4-aminotransferase activity" EXACT [EC:2.6.1.76]
synonym: "L-2,4-diaminobutyrate:2-oxoglutarate 4-aminotransferase activity" EXACT [EC:2.6.1.76]
xref: EC:2.6.1.76
xref: KEGG:R06977
xref: MetaCyc:R101-RXN
xref: RHEA:11163
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0045304
name: regulation of establishment of competence for transformation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the process in which a cell becomes able to take up and incorporate extracellular DNA into its genome." [GOC:mlg]
subset: gosubset_prok
synonym: "regulator of establishment of competence for transformation activity" RELATED []
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0032104 ! regulation of response to extracellular stimulus
is_a: GO:0043900 ! regulation of multi-organism process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030420 ! establishment of competence for transformation
relationship: regulates GO:0030420 ! establishment of competence for transformation

[Term]
id: GO:0045305
name: obsolete regulator of establishment of competence for transformation activity
namespace: molecular_function
def: "OBSOLETE. Functions to either promote or inhibit the establishment of competence for transformation." [GOC:mlg]
comment: This term was made obsolete because it does not represent a true function.
synonym: "regulator of establishment of competence for transformation activity" EXACT []
is_obsolete: true
replaced_by: GO:0045304

[Term]
id: GO:0045306
name: obsolete inhibitor of the establishment of competence for transformation activity
namespace: molecular_function
def: "OBSOLETE. Inhibits the establishment of competence for transformation." [GOC:mlg]
comment: This term was made obsolete because it does not represent a true function.
synonym: "inhibitor of the establishment of competence for transformation activity" EXACT []
is_obsolete: true
replaced_by: GO:0045808

[Term]
id: GO:0045307
name: obsolete activator of the establishment of competence for transformation activity
namespace: molecular_function
def: "OBSOLETE. Activates the establishment of competence for transformation." [GOC:mlg]
comment: This term was made obsolete because it does not represent a true function.
synonym: "activator of the establishment of competence for transformation activity" EXACT []
is_obsolete: true
replaced_by: GO:0045809

[Term]
id: GO:0045309
name: protein phosphorylated amino acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a phosphorylated amino acid residue within a protein." [GOC:go_curators]
synonym: "phosphoprotein amino acid binding" RELATED []
is_a: GO:0051219 ! phosphoprotein binding

[Term]
id: GO:0045310
name: obsolete phosphoserine/phosphothreonine binding
namespace: molecular_function
def: "OBSOLETE. Interacting selectively with a phosphorylated serine or threonine residue within a protein." [GOC:go_curators]
comment: This term was made obsolete because it represents two functions.
synonym: "phosphoserine/phosphothreonine binding" EXACT []
is_obsolete: true
consider: GO:0050815
consider: GO:0050816

[Term]
id: GO:0045311
name: invasive growth in response to pheromone
namespace: biological_process
def: "The growth of colonies in filamentous chains of cells as a result of a pheromone stimulus." [GOC:ai, GOC:dph, GOC:mcc]
is_a: GO:0036267 ! invasive filamentous growth
relationship: part_of GO:0019236 ! response to pheromone

[Term]
id: GO:0045312
name: nor-spermidine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nor-spermidine, a compound related to spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:go_curators]
synonym: "nor-spermidine anabolism" EXACT []
synonym: "nor-spermidine biosynthesis" EXACT []
synonym: "nor-spermidine formation" EXACT []
synonym: "nor-spermidine synthesis" EXACT []
is_a: GO:0006596 ! polyamine biosynthetic process
is_a: GO:0046204 ! nor-spermidine metabolic process

[Term]
id: GO:0045313
name: rhabdomere membrane biogenesis
namespace: biological_process
def: "A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a rhabdomere membrane." [GOC:jl]
is_a: GO:0044091 ! membrane biogenesis
relationship: part_of GO:0042052 ! rhabdomere development

[Term]
id: GO:0045314
name: regulation of compound eye photoreceptor development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of compound eye photoreceptor development." [GOC:bf]
synonym: "regulation of eye photoreceptor development" BROAD []
is_a: GO:0042478 ! regulation of eye photoreceptor cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042051 ! compound eye photoreceptor development
relationship: part_of GO:0046532 ! regulation of photoreceptor cell differentiation
relationship: regulates GO:0042051 ! compound eye photoreceptor development

[Term]
id: GO:0045315
name: positive regulation of compound eye photoreceptor development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of compound eye photoreceptor development." [GOC:bf]
synonym: "activation of eye photoreceptor development" BROAD []
synonym: "positive regulation of eye photoreceptor development" BROAD []
synonym: "stimulation of eye photoreceptor development" BROAD []
synonym: "up regulation of eye photoreceptor development" BROAD []
synonym: "up-regulation of eye photoreceptor development" BROAD []
synonym: "upregulation of eye photoreceptor development" BROAD []
is_a: GO:0042479 ! positive regulation of eye photoreceptor cell development
is_a: GO:0045314 ! regulation of compound eye photoreceptor development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042051 ! compound eye photoreceptor development
relationship: positively_regulates GO:0042051 ! compound eye photoreceptor development

[Term]
id: GO:0045316
name: negative regulation of compound eye photoreceptor development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of compound eye photoreceptor development." [GOC:bf]
synonym: "down regulation of eye photoreceptor development" BROAD []
synonym: "down-regulation of eye photoreceptor development" BROAD []
synonym: "downregulation of eye photoreceptor development" BROAD []
synonym: "inhibition of eye photoreceptor development" BROAD []
synonym: "negative regulation of eye photoreceptor development" BROAD []
is_a: GO:0042480 ! negative regulation of eye photoreceptor cell development
is_a: GO:0045314 ! regulation of compound eye photoreceptor development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042051 ! compound eye photoreceptor development
relationship: negatively_regulates GO:0042051 ! compound eye photoreceptor development

[Term]
id: GO:0045317
name: equator specification
namespace: biological_process
def: "The formation and development of the equator that forms the boundary between the photoreceptors in the dorsal sector of the eye and those in the ventral sector, dividing the eye into dorsal and ventral halves." [GOC:bf]
is_a: GO:0048859 ! formation of anatomical boundary
relationship: part_of GO:0042067 ! establishment of ommatidial planar polarity

[Term]
id: GO:0045319
name: obsolete SRP-independent cotranslational protein-membrane targeting, translocation
namespace: biological_process
def: "OBSOLETE. The process during cotranslational membrane targeting wherein proteins move across a membrane. This process is independent of SRP and signal recognition." [GOC:ai]
comment: This term was made obsolete because there is no evidence for the existence of this process.
synonym: "SRP-independent cotranslational membrane targeting, translocation" EXACT []
synonym: "SRP-independent cotranslational protein-membrane targeting, translocation" EXACT []
is_obsolete: true

[Term]
id: GO:0045320
name: chloroplast proton-transporting ATP synthase complex
namespace: cellular_component
def: "A proton-transporting ATP synthase complex found in the chloroplast thylakoid membrane; it catalyzes the phosphorylation of ADP to ATP during photo-phosphorylation." [GOC:mtg_sensu, GOC:pj, ISBN:0716743663]
synonym: "chloroplast hydrogen-translocating F-type ATPase complex" EXACT []
synonym: "chloroplast proton-transporting F-type ATPase complex" EXACT []
synonym: "hydrogen-translocating F-type ATPase complex" BROAD []
is_a: GO:0045259 ! proton-transporting ATP synthase complex
is_a: GO:0098807 ! chloroplast thylakoid membrane protein complex
intersection_of: GO:0045259 ! proton-transporting ATP synthase complex
intersection_of: part_of GO:0009507 ! chloroplast
relationship: part_of GO:0009507 ! chloroplast
relationship: part_of GO:0009535 ! chloroplast thylakoid membrane

[Term]
id: GO:0045321
name: leukocyte activation
namespace: biological_process
def: "A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor." [GOC:add]
synonym: "immune cell activation" EXACT []
synonym: "leucocyte activation" EXACT []
xref: Wikipedia:Immunologic_activation
is_a: GO:0001775 ! cell activation
is_a: GO:0002376 ! immune system process

[Term]
id: GO:0045322
name: unmethylated CpG binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with unmethylated CpG motifs. Unmethylated CpG dinucleotides are often associated with gene promoters." [GOC:ai, PMID:10688657]
is_a: GO:0043565 ! sequence-specific DNA binding

[Term]
id: GO:0045323
name: interleukin-1 receptor complex
namespace: cellular_component
def: "A protein complex that binds interleukin-1; comprises an alpha and a beta subunit." [GOC:mah, InterPro:IPR004075]
synonym: "IL-1 receptor complex" EXACT [GOC:add]
is_a: GO:0098802 ! plasma membrane receptor complex
relationship: part_of GO:0005887 ! integral component of plasma membrane

[Term]
id: GO:0045324
name: late endosome to vacuole transport
namespace: biological_process
def: "The directed movement of substances from late endosomes to the vacuole. In yeast, after transport to the prevacuolar compartment, endocytic content is delivered to the late endosome and on to the vacuole. This pathway is analogous to endosome to lysosome transport." [PMID:11872141]
is_a: GO:0016197 ! endosomal transport

[Term]
id: GO:0045325
name: peptidyl-tryptophan hydroxylation
namespace: biological_process
def: "The hydroxylation of peptidyl-tryptophan, to form peptidyl-L-3-hydroxytryptophan." [RESID:AA0322]
subset: gosubset_prok
xref: RESID:AA0322
is_a: GO:0018211 ! peptidyl-tryptophan modification

[Term]
id: GO:0045326
name: protein-DNA covalent cross-linking via the 3'-end to peptidyl-tyrosine
namespace: biological_process
def: "The formation of a covalent cross-link between DNA and a peptidyl-tyrosine residue by the formation of O4'-(phospho-3'-DNA)-L-tyrosine." [RESID:AA0323]
subset: gosubset_prok
synonym: "DNA-protein covalent cross-linking via the 3'-end to peptidyl-tyrosine" EXACT [GOC:mah]
xref: RESID:AA0323
is_a: GO:0045327 ! protein-DNA covalent cross-linking via peptidyl-tyrosine

[Term]
id: GO:0045327
name: protein-DNA covalent cross-linking via peptidyl-tyrosine
namespace: biological_process
def: "The formation of a covalent cross-link between DNA and a peptidyl-tyrosine residue." [GOC:jsg]
subset: gosubset_prok
synonym: "DNA-protein covalent cross-linking via peptidyl-tyrosine" EXACT [GOC:mah]
is_a: GO:0018142 ! protein-DNA covalent cross-linking
is_a: GO:0018212 ! peptidyl-tyrosine modification

[Term]
id: GO:0045328
name: cytochrome P450 4A1-heme linkage
namespace: biological_process
def: "The covalent linkage of heme to cytochrome P450 4A1 via hydroxyheme-L-glutamyl ester." [GOC:cjm, RESID:AA0324]
subset: gosubset_prok
synonym: "cytochrome P450 4A1-haem linkage" EXACT []
xref: RESID:AA0324
is_a: GO:0017003 ! protein-heme linkage
relationship: part_of GO:0017004 ! cytochrome complex assembly

[Term]
id: GO:0045329
name: carnitine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "carnitine anabolism" EXACT []
synonym: "carnitine biosynthesis" EXACT []
synonym: "carnitine formation" EXACT []
synonym: "carnitine synthesis" EXACT []
synonym: "vitamin Bt biosynthesis" EXACT []
synonym: "vitamin Bt biosynthetic process" EXACT []
xref: Reactome:REACT_100873 "Carnitine synthesis, Bos taurus"
xref: Reactome:REACT_109559 "Carnitine synthesis, Saccharomyces cerevisiae"
xref: Reactome:REACT_110019 "Carnitine synthesis, Rattus norvegicus"
xref: Reactome:REACT_115020 "Carnitine synthesis, Mycobacterium tuberculosis"
xref: Reactome:REACT_115191 "Carnitine synthesis, Staphylococcus aureus N315"
xref: Reactome:REACT_2125 "Carnitine synthesis, Homo sapiens"
xref: Reactome:REACT_33473 "Carnitine synthesis, Escherichia coli"
xref: Reactome:REACT_77876 "Carnitine synthesis, Canis familiaris"
xref: Reactome:REACT_78858 "Carnitine synthesis, Caenorhabditis elegans"
xref: Reactome:REACT_79919 "Carnitine synthesis, Danio rerio"
xref: Reactome:REACT_80289 "Carnitine synthesis, Schizosaccharomyces pombe"
xref: Reactome:REACT_82304 "Carnitine synthesis, Mus musculus"
xref: Reactome:REACT_83234 "Carnitine synthesis, Gallus gallus"
xref: Reactome:REACT_85888 "Carnitine synthesis, Plasmodium falciparum"
xref: Reactome:REACT_86387 "Carnitine synthesis, Xenopus tropicalis"
xref: Reactome:REACT_87182 "Carnitine synthesis, Oryza sativa"
xref: Reactome:REACT_87275 "Carnitine synthesis, Arabidopsis thaliana"
xref: Reactome:REACT_91272 "Carnitine synthesis, Sus scrofa"
xref: Reactome:REACT_91970 "Carnitine synthesis, Taeniopygia guttata"
xref: Reactome:REACT_97653 "Carnitine synthesis, Drosophila melanogaster"
is_a: GO:0006578 ! amino-acid betaine biosynthetic process
is_a: GO:0009437 ! carnitine metabolic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process

[Term]
id: GO:0045330
name: aspartyl esterase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue." [GOC:mah, UniProtKB-KW:KW-0063]
subset: gosubset_prok
subset: mf_needs_review
is_a: GO:0016788 ! hydrolase activity, acting on ester bonds

[Term]
id: GO:0045331
name: obsolete coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide hydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: coenzyme-M 7-mercaptoheptanoylthreonine-phosphate heterodisulfide + H2 = coenzyme-M + N-(7-mercaptoheptanoyl)threonine O3-phosphate." [EC:1.12.99.2]
comment: This term was made obsolete because it represents two activities.
synonym: "coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide hydrogenase activity" EXACT []
synonym: "coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulphide hydrogenase activity" EXACT []
synonym: "heterodisulfide reductase activity" EXACT []
is_obsolete: true
consider: GO:0051911
consider: GO:0051912

[Term]
id: GO:0045332
name: phospholipid translocation
namespace: biological_process
def: "The movement of a phospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet." [ISBN:0815316194, PMID:16452632, PMID:20043909, PMID:20302864]
comment: Note that this term describes the transbilayer motion of individual phospholipid molecules, and should not be confused with 'phospholipid scrambling ; GO:0017121'.
subset: gosubset_prok
synonym: "flippase" RELATED []
is_a: GO:0015914 ! phospholipid transport
is_a: GO:0034204 ! lipid translocation

[Term]
id: GO:0045333
name: cellular respiration
namespace: biological_process
def: "The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)." [GOC:das, ISBN:0140513590, ISBN:0198506732]
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
synonym: "oxidative metabolic process" EXACT []
synonym: "oxidative metabolism" EXACT []
synonym: "respiration" BROAD []
xref: Wikipedia:Cellular_respiration
is_a: GO:0015980 ! energy derivation by oxidation of organic compounds

[Term]
id: GO:0045334
name: clathrin-coated endocytic vesicle
namespace: cellular_component
def: "A clathrin-coated, membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance." [GOC:go_curators]
xref: NIF_Subcellular:sao1243595998
is_a: GO:0030136 ! clathrin-coated vesicle
is_a: GO:0030139 ! endocytic vesicle

[Term]
id: GO:0045335
name: phagocytic vesicle
namespace: cellular_component
def: "A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis." [GOC:go_curators, ISBN:0198506732]
synonym: "phagosome" EXACT []
xref: Wikipedia:Phagosome
is_a: GO:0030139 ! endocytic vesicle

[Term]
id: GO:0045336
name: clathrin-coated phagocytic vesicle
namespace: cellular_component
def: "A clathrin-coated, membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis." [GOC:go_curators, ISBN:0198506732]
synonym: "clathrin-coated phagosome" EXACT []
is_a: GO:0045334 ! clathrin-coated endocytic vesicle
is_a: GO:0045335 ! phagocytic vesicle

[Term]
id: GO:0045337
name: farnesyl diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of farnesyl diphosphate." [GOC:jl]
subset: gosubset_prok
synonym: "farnesyl diphosphate anabolism" EXACT []
synonym: "farnesyl diphosphate biosynthesis" EXACT []
synonym: "farnesyl diphosphate formation" EXACT []
synonym: "farnesyl diphosphate synthesis" EXACT []
xref: MetaCyc:PWY-5123
is_a: GO:0008654 ! phospholipid biosynthetic process
is_a: GO:0016114 ! terpenoid biosynthetic process
is_a: GO:0045338 ! farnesyl diphosphate metabolic process

[Term]
id: GO:0045338
name: farnesyl diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving farnesyl diphosphate, an intermediate in carotenoid, sesquiterpene, squalene and sterol biosynthesis, as well as a substrate in protein farnesylation." [GOC:go_curators]
subset: gosubset_prok
synonym: "farnesyl diphosphate metabolism" EXACT []
is_a: GO:0006644 ! phospholipid metabolic process
is_a: GO:0006721 ! terpenoid metabolic process

[Term]
id: GO:0045339
name: farnesyl diphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of farnesyl diphosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "farnesyl diphosphate breakdown" EXACT []
synonym: "farnesyl diphosphate catabolism" EXACT []
synonym: "farnesyl diphosphate degradation" EXACT []
is_a: GO:0009395 ! phospholipid catabolic process
is_a: GO:0016115 ! terpenoid catabolic process
is_a: GO:0045338 ! farnesyl diphosphate metabolic process

[Term]
id: GO:0045340
name: mercury ion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with mercury (Hg) ions." [GOC:go_curators]
subset: gosubset_prok
synonym: "mercury binding" EXACT []
is_a: GO:0046914 ! transition metal ion binding

[Term]
id: GO:0045341
name: MHC class I biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of major histocompatibility protein class I." [GOC:go_curators]
synonym: "major histocompatibility complex class I biosynthesis" EXACT []
synonym: "major histocompatibility complex class I biosynthetic process" EXACT []
synonym: "MHC class I anabolism" EXACT []
synonym: "MHC class I biosynthesis" EXACT []
synonym: "MHC class I formation" EXACT []
synonym: "MHC class I synthesis" EXACT []
is_a: GO:0009059 ! macromolecule biosynthetic process

[Term]
id: GO:0045342
name: MHC class II biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of major histocompatibility protein class II." [GOC:go_curators]
synonym: "major histocompatibility complex class II biosynthesis" EXACT []
synonym: "major histocompatibility complex class II biosynthetic process" EXACT []
synonym: "MHC class II anabolism" EXACT []
synonym: "MHC class II biosynthesis" EXACT []
synonym: "MHC class II formation" EXACT []
synonym: "MHC class II synthesis" EXACT []
is_a: GO:0009059 ! macromolecule biosynthetic process

[Term]
id: GO:0045343
name: regulation of MHC class I biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I." [GOC:go_curators]
synonym: "regulation of major histocompatibility complex class I biosynthesis" EXACT []
synonym: "regulation of major histocompatibility complex class I biosynthetic process" EXACT []
synonym: "regulation of MHC class I anabolism" EXACT []
synonym: "regulation of MHC class I biosynthesis" EXACT []
synonym: "regulation of MHC class I formation" EXACT []
synonym: "regulation of MHC class I synthesis" EXACT []
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045341 ! MHC class I biosynthetic process
relationship: regulates GO:0045341 ! MHC class I biosynthetic process

[Term]
id: GO:0045344
name: negative regulation of MHC class I biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I." [GOC:go_curators]
synonym: "down regulation of MHC class I biosynthetic process" EXACT []
synonym: "down-regulation of MHC class I biosynthetic process" EXACT []
synonym: "downregulation of MHC class I biosynthetic process" EXACT []
synonym: "inhibition of MHC class I biosynthetic process" NARROW []
synonym: "negative regulation of major histocompatibility complex class I biosynthesis" EXACT []
synonym: "negative regulation of major histocompatibility complex class I biosynthetic process" EXACT []
synonym: "negative regulation of MHC class I anabolism" EXACT []
synonym: "negative regulation of MHC class I biosynthesis" EXACT []
synonym: "negative regulation of MHC class I formation" EXACT []
synonym: "negative regulation of MHC class I synthesis" EXACT []
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
is_a: GO:0045343 ! regulation of MHC class I biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045341 ! MHC class I biosynthetic process
relationship: negatively_regulates GO:0045341 ! MHC class I biosynthetic process

[Term]
id: GO:0045345
name: positive regulation of MHC class I biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I." [GOC:go_curators]
synonym: "activation of MHC class I biosynthetic process" NARROW []
synonym: "positive regulation of major histocompatibility complex class I biosynthesis" EXACT []
synonym: "positive regulation of major histocompatibility complex class I biosynthetic process" EXACT []
synonym: "positive regulation of MHC class I anabolism" EXACT []
synonym: "positive regulation of MHC class I biosynthesis" EXACT []
synonym: "positive regulation of MHC class I formation" EXACT []
synonym: "positive regulation of MHC class I synthesis" EXACT []
synonym: "stimulation of MHC class I biosynthetic process" NARROW []
synonym: "up regulation of MHC class I biosynthetic process" EXACT []
synonym: "up-regulation of MHC class I biosynthetic process" EXACT []
synonym: "upregulation of MHC class I biosynthetic process" EXACT []
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0045343 ! regulation of MHC class I biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045341 ! MHC class I biosynthetic process
relationship: positively_regulates GO:0045341 ! MHC class I biosynthetic process

[Term]
id: GO:0045346
name: regulation of MHC class II biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II." [GOC:go_curators]
synonym: "regulation of major histocompatibility complex class II biosynthesis" EXACT []
synonym: "regulation of major histocompatibility complex class II biosynthetic process" EXACT []
synonym: "regulation of MHC class II anabolism" EXACT []
synonym: "regulation of MHC class II biosynthesis" EXACT []
synonym: "regulation of MHC class II formation" EXACT []
synonym: "regulation of MHC class II synthesis" EXACT []
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045342 ! MHC class II biosynthetic process
relationship: regulates GO:0045342 ! MHC class II biosynthetic process

[Term]
id: GO:0045347
name: negative regulation of MHC class II biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II." [GOC:go_curators]
synonym: "down regulation of MHC class II biosynthetic process" EXACT []
synonym: "down-regulation of MHC class II biosynthetic process" EXACT []
synonym: "downregulation of MHC class II biosynthetic process" EXACT []
synonym: "inhibition of MHC class II biosynthetic process" NARROW []
synonym: "negative regulation of major histocompatibility complex class II biosynthesis" EXACT []
synonym: "negative regulation of major histocompatibility complex class II biosynthetic process" EXACT []
synonym: "negative regulation of MHC class II anabolism" EXACT []
synonym: "negative regulation of MHC class II biosynthesis" EXACT []
synonym: "negative regulation of MHC class II formation" EXACT []
synonym: "negative regulation of MHC class II synthesis" EXACT []
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
is_a: GO:0045346 ! regulation of MHC class II biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045342 ! MHC class II biosynthetic process
relationship: negatively_regulates GO:0045342 ! MHC class II biosynthetic process

[Term]
id: GO:0045348
name: positive regulation of MHC class II biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II." [GOC:go_curators]
synonym: "activation of MHC class II biosynthetic process" NARROW []
synonym: "positive regulation of major histocompatibility complex class II biosynthesis" EXACT []
synonym: "positive regulation of major histocompatibility complex class II biosynthetic process" EXACT []
synonym: "positive regulation of MHC class II anabolism" EXACT []
synonym: "positive regulation of MHC class II biosynthesis" EXACT []
synonym: "positive regulation of MHC class II formation" EXACT []
synonym: "positive regulation of MHC class II synthesis" EXACT []
synonym: "stimulation of MHC class II biosynthetic process" NARROW []
synonym: "up regulation of MHC class II biosynthetic process" EXACT []
synonym: "up-regulation of MHC class II biosynthetic process" EXACT []
synonym: "upregulation of MHC class II biosynthetic process" EXACT []
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0045346 ! regulation of MHC class II biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045342 ! MHC class II biosynthetic process
relationship: positively_regulates GO:0045342 ! MHC class II biosynthetic process

[Term]
id: GO:0045349
name: interferon-alpha biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interferon-alpha." [GOC:go_curators]
synonym: "IFN-alpha biosynthesis" EXACT []
synonym: "IFN-alpha biosynthetic process" EXACT []
synonym: "interferon-alpha anabolism" EXACT []
synonym: "interferon-alpha biosynthesis" EXACT []
synonym: "interferon-alpha formation" EXACT []
synonym: "interferon-alpha synthesis" EXACT []
is_a: GO:0045351 ! type I interferon biosynthetic process
relationship: part_of GO:0032607 ! interferon-alpha production

[Term]
id: GO:0045350
name: interferon-beta biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interferon-beta." [GOC:go_curators]
synonym: "IFN-beta biosynthesis" EXACT []
synonym: "IFN-beta biosynthetic process" EXACT []
synonym: "IFNB biosynthetic process" EXACT [GOC:mah]
synonym: "interferon-beta anabolism" EXACT []
synonym: "interferon-beta biosynthesis" EXACT []
synonym: "interferon-beta formation" EXACT []
synonym: "interferon-beta synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0045351 ! type I interferon biosynthetic process
relationship: part_of GO:0032608 ! interferon-beta production

[Term]
id: GO:0045351
name: type I interferon biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any type I interferon. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add]
synonym: "interferon type I biosynthetic process" EXACT []
synonym: "type I interferon anabolism" EXACT []
synonym: "type I interferon biosynthesis" EXACT []
synonym: "type I interferon formation" EXACT []
synonym: "type I interferon synthesis" EXACT []
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032606 ! type I interferon production

[Term]
id: GO:0045352
name: interleukin-1 Type I receptor antagonist activity
namespace: molecular_function
def: "Blocks the binding of interleukin-1 to interleukin-1 Type I receptors." [GOC:ebc]
synonym: "IL-1ra type I" EXACT []
is_a: GO:0005152 ! interleukin-1 receptor antagonist activity

[Term]
id: GO:0045353
name: interleukin-1 Type II receptor antagonist activity
namespace: molecular_function
def: "Blocks the binding of interleukin-1 to interleukin-1 Type II receptors." [GOC:ebc]
synonym: "IL-1ra type II" EXACT []
is_a: GO:0005152 ! interleukin-1 receptor antagonist activity

[Term]
id: GO:0045354
name: regulation of interferon-alpha biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-alpha." [GOC:go_curators]
synonym: "regulation of interferon-alpha anabolism" EXACT []
synonym: "regulation of interferon-alpha biosynthesis" EXACT []
synonym: "regulation of interferon-alpha formation" EXACT []
synonym: "regulation of interferon-alpha synthesis" EXACT []
is_a: GO:0032647 ! regulation of interferon-alpha production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045349 ! interferon-alpha biosynthetic process
relationship: regulates GO:0045349 ! interferon-alpha biosynthetic process

[Term]
id: GO:0045355
name: negative regulation of interferon-alpha biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-alpha." [GOC:go_curators]
synonym: "down regulation of interferon-alpha biosynthetic process" EXACT []
synonym: "down-regulation of interferon-alpha biosynthetic process" EXACT []
synonym: "downregulation of interferon-alpha biosynthetic process" EXACT []
synonym: "inhibition of interferon-alpha biosynthetic process" NARROW []
synonym: "negative regulation of interferon-alpha anabolism" EXACT []
synonym: "negative regulation of interferon-alpha biosynthesis" EXACT []
synonym: "negative regulation of interferon-alpha formation" EXACT []
synonym: "negative regulation of interferon-alpha synthesis" EXACT []
is_a: GO:0032687 ! negative regulation of interferon-alpha production
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045354 ! regulation of interferon-alpha biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045349 ! interferon-alpha biosynthetic process
relationship: negatively_regulates GO:0045349 ! interferon-alpha biosynthetic process

[Term]
id: GO:0045356
name: positive regulation of interferon-alpha biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-alpha." [GOC:go_curators]
synonym: "activation of interferon-alpha biosynthetic process" NARROW []
synonym: "positive regulation of interferon-alpha anabolism" EXACT []
synonym: "positive regulation of interferon-alpha biosynthesis" EXACT []
synonym: "positive regulation of interferon-alpha formation" EXACT []
synonym: "positive regulation of interferon-alpha synthesis" EXACT []
synonym: "stimulation of interferon-alpha biosynthetic process" NARROW []
synonym: "up regulation of interferon-alpha biosynthetic process" EXACT []
synonym: "up-regulation of interferon-alpha biosynthetic process" EXACT []
synonym: "upregulation of interferon-alpha biosynthetic process" EXACT []
is_a: GO:0032727 ! positive regulation of interferon-alpha production
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045354 ! regulation of interferon-alpha biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045349 ! interferon-alpha biosynthetic process
relationship: positively_regulates GO:0045349 ! interferon-alpha biosynthetic process

[Term]
id: GO:0045357
name: regulation of interferon-beta biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-beta." [GOC:go_curators]
synonym: "regulation of interferon-beta anabolism" EXACT []
synonym: "regulation of interferon-beta biosynthesis" EXACT []
synonym: "regulation of interferon-beta formation" EXACT []
synonym: "regulation of interferon-beta synthesis" EXACT []
is_a: GO:0032648 ! regulation of interferon-beta production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045350 ! interferon-beta biosynthetic process
relationship: regulates GO:0045350 ! interferon-beta biosynthetic process

[Term]
id: GO:0045358
name: negative regulation of interferon-beta biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-beta." [GOC:go_curators]
synonym: "down regulation of interferon-beta biosynthetic process" EXACT []
synonym: "down-regulation of interferon-beta biosynthetic process" EXACT []
synonym: "downregulation of interferon-beta biosynthetic process" EXACT []
synonym: "inhibition of interferon-beta biosynthetic process" NARROW []
synonym: "negative regulation of interferon-beta anabolism" EXACT []
synonym: "negative regulation of interferon-beta biosynthesis" EXACT []
synonym: "negative regulation of interferon-beta formation" EXACT []
synonym: "negative regulation of interferon-beta synthesis" EXACT []
is_a: GO:0032688 ! negative regulation of interferon-beta production
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045357 ! regulation of interferon-beta biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045350 ! interferon-beta biosynthetic process
relationship: negatively_regulates GO:0045350 ! interferon-beta biosynthetic process

[Term]
id: GO:0045359
name: positive regulation of interferon-beta biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-beta." [GOC:go_curators]
synonym: "activation of interferon-beta biosynthetic process" NARROW []
synonym: "positive regulation of interferon-beta anabolism" EXACT []
synonym: "positive regulation of interferon-beta biosynthesis" EXACT []
synonym: "positive regulation of interferon-beta formation" EXACT []
synonym: "positive regulation of interferon-beta synthesis" EXACT []
synonym: "stimulation of interferon-beta biosynthetic process" NARROW []
synonym: "up regulation of interferon-beta biosynthetic process" EXACT []
synonym: "up-regulation of interferon-beta biosynthetic process" EXACT []
synonym: "upregulation of interferon-beta biosynthetic process" EXACT []
is_a: GO:0032728 ! positive regulation of interferon-beta production
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045357 ! regulation of interferon-beta biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045350 ! interferon-beta biosynthetic process
relationship: positively_regulates GO:0045350 ! interferon-beta biosynthetic process

[Term]
id: GO:0045360
name: regulation of interleukin-1 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1." [GOC:go_curators]
synonym: "regulation of IL-1 biosynthesis" EXACT []
synonym: "regulation of IL-1 biosynthetic process" EXACT []
synonym: "regulation of interleukin-1 anabolism" EXACT []
synonym: "regulation of interleukin-1 biosynthesis" EXACT []
synonym: "regulation of interleukin-1 formation" EXACT []
synonym: "regulation of interleukin-1 synthesis" EXACT []
is_a: GO:0032652 ! regulation of interleukin-1 production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042222 ! interleukin-1 biosynthetic process
relationship: regulates GO:0042222 ! interleukin-1 biosynthetic process

[Term]
id: GO:0045361
name: negative regulation of interleukin-1 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1." [GOC:go_curators]
synonym: "down regulation of interleukin-1 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-1 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-1 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-1 biosynthetic process" NARROW []
synonym: "negative regulation of IL-1 biosynthesis" EXACT []
synonym: "negative regulation of IL-1 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-1 anabolism" EXACT []
synonym: "negative regulation of interleukin-1 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-1 formation" EXACT []
synonym: "negative regulation of interleukin-1 synthesis" EXACT []
is_a: GO:0032692 ! negative regulation of interleukin-1 production
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045360 ! regulation of interleukin-1 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042222 ! interleukin-1 biosynthetic process
relationship: negatively_regulates GO:0042222 ! interleukin-1 biosynthetic process

[Term]
id: GO:0045362
name: positive regulation of interleukin-1 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1." [GOC:go_curators]
synonym: "activation of interleukin-1 biosynthetic process" NARROW []
synonym: "positive regulation of IL-1 biosynthesis" EXACT []
synonym: "positive regulation of IL-1 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-1 anabolism" EXACT []
synonym: "positive regulation of interleukin-1 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-1 formation" EXACT []
synonym: "positive regulation of interleukin-1 synthesis" EXACT []
synonym: "stimulation of interleukin-1 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-1 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-1 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-1 biosynthetic process" EXACT []
is_a: GO:0032732 ! positive regulation of interleukin-1 production
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045360 ! regulation of interleukin-1 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042222 ! interleukin-1 biosynthetic process
relationship: positively_regulates GO:0042222 ! interleukin-1 biosynthetic process

[Term]
id: GO:0045363
name: regulation of interleukin-11 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-11." [GOC:go_curators]
synonym: "regulation of IL-11 biosynthesis" EXACT []
synonym: "regulation of IL-11 biosynthetic process" EXACT []
synonym: "regulation of interleukin-11 anabolism" EXACT []
synonym: "regulation of interleukin-11 biosynthesis" EXACT []
synonym: "regulation of interleukin-11 formation" EXACT []
synonym: "regulation of interleukin-11 synthesis" EXACT []
is_a: GO:0032654 ! regulation of interleukin-11 production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042230 ! interleukin-11 biosynthetic process
relationship: regulates GO:0042230 ! interleukin-11 biosynthetic process

[Term]
id: GO:0045364
name: negative regulation of interleukin-11 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-11." [GOC:go_curators]
synonym: "down regulation of interleukin-11 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-11 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-11 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-11 biosynthetic process" NARROW []
synonym: "negative regulation of IL-11 biosynthesis" EXACT []
synonym: "negative regulation of IL-11 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-11 anabolism" EXACT []
synonym: "negative regulation of interleukin-11 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-11 formation" EXACT []
synonym: "negative regulation of interleukin-11 synthesis" EXACT []
is_a: GO:0032694 ! negative regulation of interleukin-11 production
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045363 ! regulation of interleukin-11 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042230 ! interleukin-11 biosynthetic process
relationship: negatively_regulates GO:0042230 ! interleukin-11 biosynthetic process

[Term]
id: GO:0045365
name: positive regulation of interleukin-11 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-11." [GOC:go_curators]
synonym: "activation of interleukin-11 biosynthetic process" NARROW []
synonym: "positive regulation of IL-11 biosynthesis" EXACT []
synonym: "positive regulation of IL-11 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-11 anabolism" EXACT []
synonym: "positive regulation of interleukin-11 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-11 formation" EXACT []
synonym: "positive regulation of interleukin-11 synthesis" EXACT []
synonym: "stimulation of interleukin-11 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-11 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-11 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-11 biosynthetic process" EXACT []
is_a: GO:0032734 ! positive regulation of interleukin-11 production
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045363 ! regulation of interleukin-11 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042230 ! interleukin-11 biosynthetic process
relationship: positively_regulates GO:0042230 ! interleukin-11 biosynthetic process

[Term]
id: GO:0045366
name: regulation of interleukin-13 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-13." [GOC:go_curators]
synonym: "regulation of IL-13 biosynthesis" EXACT []
synonym: "regulation of IL-13 biosynthetic process" EXACT []
synonym: "regulation of interleukin-13 anabolism" EXACT []
synonym: "regulation of interleukin-13 biosynthesis" EXACT []
synonym: "regulation of interleukin-13 formation" EXACT []
synonym: "regulation of interleukin-13 synthesis" EXACT []
is_a: GO:0032656 ! regulation of interleukin-13 production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042231 ! interleukin-13 biosynthetic process
relationship: regulates GO:0042231 ! interleukin-13 biosynthetic process

[Term]
id: GO:0045367
name: negative regulation of interleukin-13 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-13." [GOC:go_curators]
synonym: "down regulation of interleukin-13 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-13 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-13 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-13 biosynthetic process" NARROW []
synonym: "negative regulation of IL-13 biosynthesis" EXACT []
synonym: "negative regulation of IL-13 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-13 anabolism" EXACT []
synonym: "negative regulation of interleukin-13 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-13 formation" EXACT []
synonym: "negative regulation of interleukin-13 synthesis" EXACT []
is_a: GO:0032696 ! negative regulation of interleukin-13 production
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045366 ! regulation of interleukin-13 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042231 ! interleukin-13 biosynthetic process
relationship: negatively_regulates GO:0042231 ! interleukin-13 biosynthetic process

[Term]
id: GO:0045368
name: positive regulation of interleukin-13 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-13." [GOC:go_curators]
synonym: "activation of interleukin-13 biosynthetic process" NARROW []
synonym: "positive regulation of IL-13 biosynthesis" EXACT []
synonym: "positive regulation of IL-13 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-13 anabolism" EXACT []
synonym: "positive regulation of interleukin-13 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-13 formation" EXACT []
synonym: "positive regulation of interleukin-13 synthesis" EXACT []
synonym: "stimulation of interleukin-13 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-13 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-13 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-13 biosynthetic process" EXACT []
is_a: GO:0032736 ! positive regulation of interleukin-13 production
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045366 ! regulation of interleukin-13 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042231 ! interleukin-13 biosynthetic process
relationship: positively_regulates GO:0042231 ! interleukin-13 biosynthetic process

[Term]
id: GO:0045369
name: regulation of interleukin-14 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-14." [GOC:go_curators]
synonym: "regulation of IL-14 biosynthesis" EXACT []
synonym: "regulation of IL-14 biosynthetic process" EXACT []
synonym: "regulation of interleukin-14 anabolism" EXACT []
synonym: "regulation of interleukin-14 biosynthesis" EXACT []
synonym: "regulation of interleukin-14 formation" EXACT []
synonym: "regulation of interleukin-14 synthesis" EXACT []
is_a: GO:0032657 ! regulation of interleukin-14 production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042232 ! interleukin-14 biosynthetic process
relationship: regulates GO:0042232 ! interleukin-14 biosynthetic process

[Term]
id: GO:0045370
name: negative regulation of interleukin-14 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-14." [GOC:go_curators]
synonym: "down regulation of interleukin-14 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-14 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-14 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-14 biosynthetic process" NARROW []
synonym: "negative regulation of IL-14 biosynthesis" EXACT []
synonym: "negative regulation of IL-14 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-14 anabolism" EXACT []
synonym: "negative regulation of interleukin-14 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-14 formation" EXACT []
synonym: "negative regulation of interleukin-14 synthesis" EXACT []
is_a: GO:0032697 ! negative regulation of interleukin-14 production
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045369 ! regulation of interleukin-14 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042232 ! interleukin-14 biosynthetic process
relationship: negatively_regulates GO:0042232 ! interleukin-14 biosynthetic process

[Term]
id: GO:0045371
name: positive regulation of interleukin-14 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-14." [GOC:go_curators]
synonym: "activation of interleukin-14 biosynthetic process" NARROW []
synonym: "positive regulation of IL-14 biosynthesis" EXACT []
synonym: "positive regulation of IL-14 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-14 anabolism" EXACT []
synonym: "positive regulation of interleukin-14 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-14 formation" EXACT []
synonym: "positive regulation of interleukin-14 synthesis" EXACT []
synonym: "stimulation of interleukin-14 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-14 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-14 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-14 biosynthetic process" EXACT []
is_a: GO:0032737 ! positive regulation of interleukin-14 production
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045369 ! regulation of interleukin-14 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042232 ! interleukin-14 biosynthetic process
relationship: positively_regulates GO:0042232 ! interleukin-14 biosynthetic process

[Term]
id: GO:0045372
name: regulation of interleukin-15 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-15." [GOC:go_curators]
synonym: "regulation of IL-15 biosynthesis" EXACT []
synonym: "regulation of IL-15 biosynthetic process" EXACT []
synonym: "regulation of interleukin-15 anabolism" EXACT []
synonym: "regulation of interleukin-15 biosynthesis" EXACT []
synonym: "regulation of interleukin-15 formation" EXACT []
synonym: "regulation of interleukin-15 synthesis" EXACT []
is_a: GO:0032658 ! regulation of interleukin-15 production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042233 ! interleukin-15 biosynthetic process
relationship: regulates GO:0042233 ! interleukin-15 biosynthetic process

[Term]
id: GO:0045373
name: negative regulation of interleukin-15 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-15." [GOC:go_curators]
synonym: "down regulation of interleukin-15 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-15 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-15 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-15 biosynthetic process" NARROW []
synonym: "negative regulation of IL-15 biosynthesis" EXACT []
synonym: "negative regulation of IL-15 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-15 anabolism" EXACT []
synonym: "negative regulation of interleukin-15 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-15 formation" EXACT []
synonym: "negative regulation of interleukin-15 synthesis" EXACT []
is_a: GO:0032698 ! negative regulation of interleukin-15 production
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045372 ! regulation of interleukin-15 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042233 ! interleukin-15 biosynthetic process
relationship: negatively_regulates GO:0042233 ! interleukin-15 biosynthetic process

[Term]
id: GO:0045374
name: positive regulation of interleukin-15 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-15." [GOC:go_curators]
synonym: "activation of interleukin-15 biosynthetic process" NARROW []
synonym: "positive regulation of IL-15 biosynthesis" EXACT []
synonym: "positive regulation of IL-15 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-15 anabolism" EXACT []
synonym: "positive regulation of interleukin-15 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-15 formation" EXACT []
synonym: "positive regulation of interleukin-15 synthesis" EXACT []
synonym: "stimulation of interleukin-15 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-15 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-15 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-15 biosynthetic process" EXACT []
is_a: GO:0032738 ! positive regulation of interleukin-15 production
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045372 ! regulation of interleukin-15 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042233 ! interleukin-15 biosynthetic process
relationship: positively_regulates GO:0042233 ! interleukin-15 biosynthetic process

[Term]
id: GO:0045375
name: regulation of interleukin-16 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-16." [GOC:go_curators]
synonym: "regulation of IL-16 biosynthesis" EXACT []
synonym: "regulation of IL-16 biosynthetic process" EXACT []
synonym: "regulation of interleukin-16 anabolism" EXACT []
synonym: "regulation of interleukin-16 biosynthesis" EXACT []
synonym: "regulation of interleukin-16 formation" EXACT []
synonym: "regulation of interleukin-16 synthesis" EXACT []
is_a: GO:0032659 ! regulation of interleukin-16 production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042234 ! interleukin-16 biosynthetic process
relationship: regulates GO:0042234 ! interleukin-16 biosynthetic process

[Term]
id: GO:0045376
name: negative regulation of interleukin-16 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-16." [GOC:go_curators]
synonym: "down regulation of interleukin-16 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-16 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-16 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-16 biosynthetic process" NARROW []
synonym: "negative regulation of IL-16 biosynthesis" EXACT []
synonym: "negative regulation of IL-16 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-16 anabolism" EXACT []
synonym: "negative regulation of interleukin-16 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-16 formation" EXACT []
synonym: "negative regulation of interleukin-16 synthesis" EXACT []
is_a: GO:0032699 ! negative regulation of interleukin-16 production
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045375 ! regulation of interleukin-16 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042234 ! interleukin-16 biosynthetic process
relationship: negatively_regulates GO:0042234 ! interleukin-16 biosynthetic process

[Term]
id: GO:0045377
name: positive regulation of interleukin-16 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-16." [GOC:go_curators]
synonym: "activation of interleukin-16 biosynthetic process" NARROW []
synonym: "positive regulation of IL-16 biosynthesis" EXACT []
synonym: "positive regulation of IL-16 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-16 anabolism" EXACT []
synonym: "positive regulation of interleukin-16 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-16 formation" EXACT []
synonym: "positive regulation of interleukin-16 synthesis" EXACT []
synonym: "stimulation of interleukin-16 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-16 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-16 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-16 biosynthetic process" EXACT []
is_a: GO:0032739 ! positive regulation of interleukin-16 production
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045375 ! regulation of interleukin-16 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042234 ! interleukin-16 biosynthetic process
relationship: positively_regulates GO:0042234 ! interleukin-16 biosynthetic process

[Term]
id: GO:0045378
name: regulation of interleukin-17 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of any member of the interleukin-17 family of cytokines." [GOC:add, GOC:go_curators]
synonym: "regulation of IL-17 biosynthesis" EXACT []
synonym: "regulation of IL-17 biosynthetic process" EXACT []
synonym: "regulation of interleukin-17 anabolism" EXACT []
synonym: "regulation of interleukin-17 biosynthesis" EXACT []
synonym: "regulation of interleukin-17 formation" EXACT []
synonym: "regulation of interleukin-17 synthesis" EXACT []
is_a: GO:0032660 ! regulation of interleukin-17 production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042235 ! interleukin-17 biosynthetic process
relationship: regulates GO:0042235 ! interleukin-17 biosynthetic process

[Term]
id: GO:0045379
name: negative regulation of interleukin-17 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of any member of the interleukin-17 family of cytokines." [GOC:add, GOC:go_curators]
synonym: "down regulation of interleukin-17 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-17 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-17 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-17 biosynthetic process" NARROW []
synonym: "negative regulation of IL-17 biosynthesis" EXACT []
synonym: "negative regulation of IL-17 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-17 anabolism" EXACT []
synonym: "negative regulation of interleukin-17 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-17 formation" EXACT []
synonym: "negative regulation of interleukin-17 synthesis" EXACT []
is_a: GO:0032700 ! negative regulation of interleukin-17 production
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045378 ! regulation of interleukin-17 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042235 ! interleukin-17 biosynthetic process
relationship: negatively_regulates GO:0042235 ! interleukin-17 biosynthetic process

[Term]
id: GO:0045380
name: positive regulation of interleukin-17 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of any member of the interleukin-17 family of cytokines." [GOC:add, GOC:go_curators]
synonym: "activation of interleukin-17 biosynthetic process" NARROW []
synonym: "positive regulation of IL-17 biosynthesis" EXACT []
synonym: "positive regulation of IL-17 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-17 anabolism" EXACT []
synonym: "positive regulation of interleukin-17 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-17 formation" EXACT []
synonym: "positive regulation of interleukin-17 synthesis" EXACT []
synonym: "stimulation of interleukin-17 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-17 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-17 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-17 biosynthetic process" EXACT []
is_a: GO:0032740 ! positive regulation of interleukin-17 production
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045378 ! regulation of interleukin-17 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042235 ! interleukin-17 biosynthetic process
relationship: positively_regulates GO:0042235 ! interleukin-17 biosynthetic process

[Term]
id: GO:0045381
name: regulation of interleukin-18 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-18." [GOC:go_curators]
synonym: "regulation of IL-18 biosynthesis" EXACT []
synonym: "regulation of IL-18 biosynthetic process" EXACT []
synonym: "regulation of interleukin-18 anabolism" EXACT []
synonym: "regulation of interleukin-18 biosynthesis" EXACT []
synonym: "regulation of interleukin-18 formation" EXACT []
synonym: "regulation of interleukin-18 synthesis" EXACT []
is_a: GO:0032661 ! regulation of interleukin-18 production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042241 ! interleukin-18 biosynthetic process
relationship: regulates GO:0042241 ! interleukin-18 biosynthetic process

[Term]
id: GO:0045382
name: negative regulation of interleukin-18 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-18." [GOC:go_curators]
synonym: "down regulation of interleukin-18 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-18 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-18 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-18 biosynthetic process" NARROW []
synonym: "negative regulation of IL-18 biosynthesis" EXACT []
synonym: "negative regulation of IL-18 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-18 anabolism" EXACT []
synonym: "negative regulation of interleukin-18 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-18 formation" EXACT []
synonym: "negative regulation of interleukin-18 synthesis" EXACT []
is_a: GO:0032701 ! negative regulation of interleukin-18 production
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045381 ! regulation of interleukin-18 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042241 ! interleukin-18 biosynthetic process
relationship: negatively_regulates GO:0042241 ! interleukin-18 biosynthetic process

[Term]
id: GO:0045383
name: positive regulation of interleukin-18 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-18." [GOC:go_curators]
synonym: "activation of interleukin-18 biosynthetic process" NARROW []
synonym: "positive regulation of IL-18 biosynthesis" EXACT []
synonym: "positive regulation of IL-18 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-18 anabolism" EXACT []
synonym: "positive regulation of interleukin-18 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-18 formation" EXACT []
synonym: "positive regulation of interleukin-18 synthesis" EXACT []
synonym: "stimulation of interleukin-18 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-18 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-18 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-18 biosynthetic process" EXACT []
is_a: GO:0032741 ! positive regulation of interleukin-18 production
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045381 ! regulation of interleukin-18 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042241 ! interleukin-18 biosynthetic process
relationship: positively_regulates GO:0042241 ! interleukin-18 biosynthetic process

[Term]
id: GO:0045384
name: regulation of interleukin-19 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-19." [GOC:go_curators]
synonym: "regulation of IL-19 biosynthesis" EXACT []
synonym: "regulation of IL-19 biosynthetic process" EXACT []
synonym: "regulation of interleukin-19 anabolism" EXACT []
synonym: "regulation of interleukin-19 biosynthesis" EXACT []
synonym: "regulation of interleukin-19 formation" EXACT []
synonym: "regulation of interleukin-19 synthesis" EXACT []
is_a: GO:0032662 ! regulation of interleukin-19 production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042236 ! interleukin-19 biosynthetic process
relationship: regulates GO:0042236 ! interleukin-19 biosynthetic process

[Term]
id: GO:0045385
name: negative regulation of interleukin-19 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-19." [GOC:go_curators]
synonym: "down regulation of interleukin-19 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-19 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-19 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-19 biosynthetic process" NARROW []
synonym: "negative regulation of IL-19 biosynthesis" EXACT []
synonym: "negative regulation of IL-19 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-19 anabolism" EXACT []
synonym: "negative regulation of interleukin-19 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-19 formation" EXACT []
synonym: "negative regulation of interleukin-19 synthesis" EXACT []
is_a: GO:0032702 ! negative regulation of interleukin-19 production
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045384 ! regulation of interleukin-19 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042236 ! interleukin-19 biosynthetic process
relationship: negatively_regulates GO:0042236 ! interleukin-19 biosynthetic process

[Term]
id: GO:0045386
name: positive regulation of interleukin-19 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-19." [GOC:go_curators]
synonym: "activation of interleukin-19 biosynthetic process" NARROW []
synonym: "positive regulation of IL-19 biosynthesis" EXACT []
synonym: "positive regulation of IL-19 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-19 anabolism" EXACT []
synonym: "positive regulation of interleukin-19 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-19 formation" EXACT []
synonym: "positive regulation of interleukin-19 synthesis" EXACT []
synonym: "stimulation of interleukin-19 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-19 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-19 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-19 biosynthetic process" EXACT []
is_a: GO:0032742 ! positive regulation of interleukin-19 production
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045384 ! regulation of interleukin-19 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042236 ! interleukin-19 biosynthetic process
relationship: positively_regulates GO:0042236 ! interleukin-19 biosynthetic process

[Term]
id: GO:0045387
name: regulation of interleukin-20 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-20." [GOC:go_curators]
synonym: "regulation of IL-20 biosynthesis" EXACT []
synonym: "regulation of IL-20 biosynthetic process" EXACT []
synonym: "regulation of interleukin-20 anabolism" EXACT []
synonym: "regulation of interleukin-20 biosynthesis" EXACT []
synonym: "regulation of interleukin-20 formation" EXACT []
synonym: "regulation of interleukin-20 synthesis" EXACT []
is_a: GO:0032664 ! regulation of interleukin-20 production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042237 ! interleukin-20 biosynthetic process
relationship: regulates GO:0042237 ! interleukin-20 biosynthetic process

[Term]
id: GO:0045388
name: negative regulation of interleukin-20 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-20." [GOC:go_curators]
synonym: "down regulation of interleukin-20 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-20 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-20 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-20 biosynthetic process" NARROW []
synonym: "negative regulation of IL-20 biosynthesis" EXACT []
synonym: "negative regulation of IL-20 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-20 anabolism" EXACT []
synonym: "negative regulation of interleukin-20 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-20 formation" EXACT []
synonym: "negative regulation of interleukin-20 synthesis" EXACT []
is_a: GO:0032704 ! negative regulation of interleukin-20 production
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045387 ! regulation of interleukin-20 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042237 ! interleukin-20 biosynthetic process
relationship: negatively_regulates GO:0042237 ! interleukin-20 biosynthetic process

[Term]
id: GO:0045389
name: positive regulation of interleukin-20 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-20." [GOC:go_curators]
synonym: "activation of interleukin-20 biosynthetic process" NARROW []
synonym: "positive regulation of IL-20 biosynthesis" EXACT []
synonym: "positive regulation of IL-20 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-20 anabolism" EXACT []
synonym: "positive regulation of interleukin-20 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-20 formation" EXACT []
synonym: "positive regulation of interleukin-20 synthesis" EXACT []
synonym: "stimulation of interleukin-20 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-20 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-20 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-20 biosynthetic process" EXACT []
is_a: GO:0032744 ! positive regulation of interleukin-20 production
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045387 ! regulation of interleukin-20 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042237 ! interleukin-20 biosynthetic process
relationship: positively_regulates GO:0042237 ! interleukin-20 biosynthetic process

[Term]
id: GO:0045390
name: regulation of interleukin-21 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-21." [GOC:go_curators]
synonym: "regulation of IL-21 biosynthesis" EXACT []
synonym: "regulation of IL-21 biosynthetic process" EXACT []
synonym: "regulation of interleukin-21 anabolism" EXACT []
synonym: "regulation of interleukin-21 biosynthesis" EXACT []
synonym: "regulation of interleukin-21 formation" EXACT []
synonym: "regulation of interleukin-21 synthesis" EXACT []
is_a: GO:0032665 ! regulation of interleukin-21 production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042238 ! interleukin-21 biosynthetic process
relationship: regulates GO:0042238 ! interleukin-21 biosynthetic process

[Term]
id: GO:0045391
name: negative regulation of interleukin-21 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-21." [GOC:go_curators]
synonym: "down regulation of interleukin-21 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-21 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-21 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-21 biosynthetic process" NARROW []
synonym: "negative regulation of IL-21 biosynthesis" EXACT []
synonym: "negative regulation of IL-21 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-21 anabolism" EXACT []
synonym: "negative regulation of interleukin-21 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-21 formation" EXACT []
synonym: "negative regulation of interleukin-21 synthesis" EXACT []
is_a: GO:0032705 ! negative regulation of interleukin-21 production
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045390 ! regulation of interleukin-21 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042238 ! interleukin-21 biosynthetic process
relationship: negatively_regulates GO:0042238 ! interleukin-21 biosynthetic process

[Term]
id: GO:0045392
name: positive regulation of interleukin-21 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-21." [GOC:go_curators]
synonym: "activation of interleukin-21 biosynthetic process" NARROW []
synonym: "positive regulation of IL-21 biosynthesis" EXACT []
synonym: "positive regulation of IL-21 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-21 anabolism" EXACT []
synonym: "positive regulation of interleukin-21 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-21 formation" EXACT []
synonym: "positive regulation of interleukin-21 synthesis" EXACT []
synonym: "stimulation of interleukin-21 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-21 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-21 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-21 biosynthetic process" EXACT []
is_a: GO:0032745 ! positive regulation of interleukin-21 production
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045390 ! regulation of interleukin-21 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042238 ! interleukin-21 biosynthetic process
relationship: positively_regulates GO:0042238 ! interleukin-21 biosynthetic process

[Term]
id: GO:0045393
name: regulation of interleukin-22 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-22." [GOC:go_curators]
synonym: "regulation of IL-22 biosynthesis" EXACT []
synonym: "regulation of IL-22 biosynthetic process" EXACT []
synonym: "regulation of interleukin-22 anabolism" EXACT []
synonym: "regulation of interleukin-22 biosynthesis" EXACT []
synonym: "regulation of interleukin-22 formation" EXACT []
synonym: "regulation of interleukin-22 synthesis" EXACT []
is_a: GO:0032666 ! regulation of interleukin-22 production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042239 ! interleukin-22 biosynthetic process
relationship: regulates GO:0042239 ! interleukin-22 biosynthetic process

[Term]
id: GO:0045394
name: negative regulation of interleukin-22 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-22." [GOC:go_curators]
synonym: "down regulation of interleukin-22 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-22 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-22 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-22 biosynthetic process" NARROW []
synonym: "negative regulation of IL-22 biosynthesis" EXACT []
synonym: "negative regulation of IL-22 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-22 anabolism" EXACT []
synonym: "negative regulation of interleukin-22 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-22 formation" EXACT []
synonym: "negative regulation of interleukin-22 synthesis" EXACT []
is_a: GO:0032706 ! negative regulation of interleukin-22 production
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045393 ! regulation of interleukin-22 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042239 ! interleukin-22 biosynthetic process
relationship: negatively_regulates GO:0042239 ! interleukin-22 biosynthetic process

[Term]
id: GO:0045395
name: positive regulation of interleukin-22 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-22." [GOC:go_curators]
synonym: "activation of interleukin-22 biosynthetic process" NARROW []
synonym: "positive regulation of IL-22 biosynthesis" EXACT []
synonym: "positive regulation of IL-22 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-22 anabolism" EXACT []
synonym: "positive regulation of interleukin-22 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-22 formation" EXACT []
synonym: "positive regulation of interleukin-22 synthesis" EXACT []
synonym: "stimulation of interleukin-22 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-22 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-22 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-22 biosynthetic process" EXACT []
is_a: GO:0032746 ! positive regulation of interleukin-22 production
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045393 ! regulation of interleukin-22 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042239 ! interleukin-22 biosynthetic process
relationship: positively_regulates GO:0042239 ! interleukin-22 biosynthetic process

[Term]
id: GO:0045396
name: regulation of interleukin-23 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-23." [GOC:go_curators]
synonym: "regulation of IL-23 biosynthesis" EXACT []
synonym: "regulation of IL-23 biosynthetic process" EXACT []
synonym: "regulation of interleukin-23 anabolism" EXACT []
synonym: "regulation of interleukin-23 biosynthesis" EXACT []
synonym: "regulation of interleukin-23 formation" EXACT []
synonym: "regulation of interleukin-23 synthesis" EXACT []
is_a: GO:0032667 ! regulation of interleukin-23 production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042240 ! interleukin-23 biosynthetic process
relationship: regulates GO:0042240 ! interleukin-23 biosynthetic process

[Term]
id: GO:0045397
name: negative regulation of interleukin-23 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-23." [GOC:go_curators]
synonym: "down regulation of interleukin-23 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-23 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-23 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-23 biosynthetic process" NARROW []
synonym: "negative regulation of IL-23 biosynthesis" EXACT []
synonym: "negative regulation of IL-23 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-23 anabolism" EXACT []
synonym: "negative regulation of interleukin-23 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-23 formation" EXACT []
synonym: "negative regulation of interleukin-23 synthesis" EXACT []
is_a: GO:0032707 ! negative regulation of interleukin-23 production
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045396 ! regulation of interleukin-23 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042240 ! interleukin-23 biosynthetic process
relationship: negatively_regulates GO:0042240 ! interleukin-23 biosynthetic process

[Term]
id: GO:0045398
name: positive regulation of interleukin-23 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-23." [GOC:go_curators]
synonym: "activation of interleukin-23 biosynthetic process" NARROW []
synonym: "positive regulation of IL-23 biosynthesis" EXACT []
synonym: "positive regulation of IL-23 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-23 anabolism" EXACT []
synonym: "positive regulation of interleukin-23 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-23 formation" EXACT []
synonym: "positive regulation of interleukin-23 synthesis" EXACT []
synonym: "stimulation of interleukin-23 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-23 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-23 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-23 biosynthetic process" EXACT []
is_a: GO:0032747 ! positive regulation of interleukin-23 production
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045396 ! regulation of interleukin-23 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042240 ! interleukin-23 biosynthetic process
relationship: positively_regulates GO:0042240 ! interleukin-23 biosynthetic process

[Term]
id: GO:0045399
name: regulation of interleukin-3 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-3." [GOC:go_curators]
synonym: "regulation of IL-3 biosynthesis" EXACT []
synonym: "regulation of IL-3 biosynthetic process" EXACT []
synonym: "regulation of interleukin-3 anabolism" EXACT []
synonym: "regulation of interleukin-3 biosynthesis" EXACT []
synonym: "regulation of interleukin-3 formation" EXACT []
synonym: "regulation of interleukin-3 synthesis" EXACT []
is_a: GO:0032672 ! regulation of interleukin-3 production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042223 ! interleukin-3 biosynthetic process
relationship: regulates GO:0042223 ! interleukin-3 biosynthetic process

[Term]
id: GO:0045400
name: negative regulation of interleukin-3 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-3." [GOC:go_curators]
synonym: "down regulation of interleukin-3 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-3 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-3 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-3 biosynthetic process" NARROW []
synonym: "negative regulation of IL-3 biosynthesis" EXACT []
synonym: "negative regulation of IL-3 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-3 anabolism" EXACT []
synonym: "negative regulation of interleukin-3 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-3 formation" EXACT []
synonym: "negative regulation of interleukin-3 synthesis" EXACT []
is_a: GO:0032712 ! negative regulation of interleukin-3 production
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045399 ! regulation of interleukin-3 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042223 ! interleukin-3 biosynthetic process
relationship: negatively_regulates GO:0042223 ! interleukin-3 biosynthetic process

[Term]
id: GO:0045401
name: positive regulation of interleukin-3 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-3." [GOC:go_curators]
synonym: "activation of interleukin-3 biosynthetic process" NARROW []
synonym: "positive regulation of IL-3 biosynthesis" EXACT []
synonym: "positive regulation of IL-3 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-3 anabolism" EXACT []
synonym: "positive regulation of interleukin-3 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-3 formation" EXACT []
synonym: "positive regulation of interleukin-3 synthesis" EXACT []
synonym: "stimulation of interleukin-3 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-3 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-3 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-3 biosynthetic process" EXACT []
is_a: GO:0032752 ! positive regulation of interleukin-3 production
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045399 ! regulation of interleukin-3 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042223 ! interleukin-3 biosynthetic process
relationship: positively_regulates GO:0042223 ! interleukin-3 biosynthetic process

[Term]
id: GO:0045402
name: regulation of interleukin-4 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-4." [GOC:go_curators]
synonym: "regulation of IL-4 biosynthesis" EXACT []
synonym: "regulation of IL-4 biosynthetic process" EXACT []
synonym: "regulation of interleukin-4 anabolism" EXACT []
synonym: "regulation of interleukin-4 biosynthesis" EXACT []
synonym: "regulation of interleukin-4 formation" EXACT []
synonym: "regulation of interleukin-4 synthesis" EXACT []
is_a: GO:0032673 ! regulation of interleukin-4 production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042097 ! interleukin-4 biosynthetic process
relationship: regulates GO:0042097 ! interleukin-4 biosynthetic process

[Term]
id: GO:0045403
name: negative regulation of interleukin-4 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-4." [GOC:go_curators]
synonym: "down regulation of interleukin-4 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-4 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-4 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-4 biosynthetic process" NARROW []
synonym: "negative regulation of IL-4 biosynthesis" EXACT []
synonym: "negative regulation of IL-4 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-4 anabolism" EXACT []
synonym: "negative regulation of interleukin-4 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-4 formation" EXACT []
synonym: "negative regulation of interleukin-4 synthesis" EXACT []
is_a: GO:0032713 ! negative regulation of interleukin-4 production
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045402 ! regulation of interleukin-4 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042097 ! interleukin-4 biosynthetic process
relationship: negatively_regulates GO:0042097 ! interleukin-4 biosynthetic process

[Term]
id: GO:0045404
name: positive regulation of interleukin-4 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-4." [GOC:go_curators]
synonym: "activation of interleukin-4 biosynthetic process" NARROW []
synonym: "positive regulation of IL-4 biosynthesis" EXACT []
synonym: "positive regulation of IL-4 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-4 anabolism" EXACT []
synonym: "positive regulation of interleukin-4 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-4 formation" EXACT []
synonym: "positive regulation of interleukin-4 synthesis" EXACT []
synonym: "stimulation of interleukin-4 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-4 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-4 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-4 biosynthetic process" EXACT []
is_a: GO:0032753 ! positive regulation of interleukin-4 production
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045402 ! regulation of interleukin-4 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042097 ! interleukin-4 biosynthetic process
relationship: positively_regulates GO:0042097 ! interleukin-4 biosynthetic process

[Term]
id: GO:0045405
name: regulation of interleukin-5 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-5." [GOC:go_curators]
synonym: "regulation of IL-5 biosynthesis" EXACT []
synonym: "regulation of IL-5 biosynthetic process" EXACT []
synonym: "regulation of interleukin-5 anabolism" EXACT []
synonym: "regulation of interleukin-5 biosynthesis" EXACT []
synonym: "regulation of interleukin-5 formation" EXACT []
synonym: "regulation of interleukin-5 synthesis" EXACT []
is_a: GO:0032674 ! regulation of interleukin-5 production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042225 ! interleukin-5 biosynthetic process
relationship: regulates GO:0042225 ! interleukin-5 biosynthetic process

[Term]
id: GO:0045406
name: negative regulation of interleukin-5 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-5." [GOC:go_curators]
synonym: "down regulation of interleukin-5 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-5 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-5 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-5 biosynthetic process" NARROW []
synonym: "negative regulation of IL-5 biosynthesis" EXACT []
synonym: "negative regulation of IL-5 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-5 anabolism" EXACT []
synonym: "negative regulation of interleukin-5 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-5 formation" EXACT []
synonym: "negative regulation of interleukin-5 synthesis" EXACT []
is_a: GO:0032714 ! negative regulation of interleukin-5 production
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045405 ! regulation of interleukin-5 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042225 ! interleukin-5 biosynthetic process
relationship: negatively_regulates GO:0042225 ! interleukin-5 biosynthetic process

[Term]
id: GO:0045407
name: positive regulation of interleukin-5 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-5." [GOC:go_curators]
synonym: "activation of interleukin-5 biosynthetic process" NARROW []
synonym: "positive regulation of IL-5 biosynthesis" EXACT []
synonym: "positive regulation of IL-5 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-5 anabolism" EXACT []
synonym: "positive regulation of interleukin-5 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-5 formation" EXACT []
synonym: "positive regulation of interleukin-5 synthesis" EXACT []
synonym: "stimulation of interleukin-5 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-5 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-5 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-5 biosynthetic process" EXACT []
is_a: GO:0032754 ! positive regulation of interleukin-5 production
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045405 ! regulation of interleukin-5 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042225 ! interleukin-5 biosynthetic process
relationship: positively_regulates GO:0042225 ! interleukin-5 biosynthetic process

[Term]
id: GO:0045408
name: regulation of interleukin-6 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6." [GOC:go_curators]
synonym: "regulation of IL-6 biosynthesis" EXACT []
synonym: "regulation of IL-6 biosynthetic process" EXACT []
synonym: "regulation of interleukin-6 anabolism" EXACT []
synonym: "regulation of interleukin-6 biosynthesis" EXACT []
synonym: "regulation of interleukin-6 formation" EXACT []
synonym: "regulation of interleukin-6 synthesis" EXACT []
is_a: GO:0032675 ! regulation of interleukin-6 production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042226 ! interleukin-6 biosynthetic process
relationship: regulates GO:0042226 ! interleukin-6 biosynthetic process

[Term]
id: GO:0045409
name: negative regulation of interleukin-6 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6." [GOC:go_curators]
synonym: "down regulation of interleukin-6 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-6 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-6 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-6 biosynthetic process" NARROW []
synonym: "negative regulation of IL-6 biosynthesis" EXACT []
synonym: "negative regulation of IL-6 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-6 anabolism" EXACT []
synonym: "negative regulation of interleukin-6 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-6 formation" EXACT []
synonym: "negative regulation of interleukin-6 synthesis" EXACT []
is_a: GO:0032715 ! negative regulation of interleukin-6 production
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045408 ! regulation of interleukin-6 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042226 ! interleukin-6 biosynthetic process
relationship: negatively_regulates GO:0042226 ! interleukin-6 biosynthetic process

[Term]
id: GO:0045410
name: positive regulation of interleukin-6 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6." [GOC:go_curators]
synonym: "activation of interleukin-6 biosynthetic process" NARROW []
synonym: "positive regulation of IL-6 biosynthesis" EXACT []
synonym: "positive regulation of IL-6 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-6 anabolism" EXACT []
synonym: "positive regulation of interleukin-6 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-6 formation" EXACT []
synonym: "positive regulation of interleukin-6 synthesis" EXACT []
synonym: "stimulation of interleukin-6 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-6 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-6 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-6 biosynthetic process" EXACT []
is_a: GO:0032755 ! positive regulation of interleukin-6 production
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045408 ! regulation of interleukin-6 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042226 ! interleukin-6 biosynthetic process
relationship: positively_regulates GO:0042226 ! interleukin-6 biosynthetic process

[Term]
id: GO:0045411
name: regulation of interleukin-7 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-7." [GOC:go_curators]
synonym: "regulation of IL-7 biosynthesis" EXACT []
synonym: "regulation of IL-7 biosynthetic process" EXACT []
synonym: "regulation of interleukin-7 anabolism" EXACT []
synonym: "regulation of interleukin-7 biosynthesis" EXACT []
synonym: "regulation of interleukin-7 formation" EXACT []
synonym: "regulation of interleukin-7 synthesis" EXACT []
is_a: GO:0032676 ! regulation of interleukin-7 production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042227 ! interleukin-7 biosynthetic process
relationship: regulates GO:0042227 ! interleukin-7 biosynthetic process

[Term]
id: GO:0045412
name: negative regulation of interleukin-7 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-7." [GOC:go_curators]
synonym: "down regulation of interleukin-7 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-7 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-7 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-7 biosynthetic process" NARROW []
synonym: "negative regulation of IL-7 biosynthesis" EXACT []
synonym: "negative regulation of IL-7 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-7 anabolism" EXACT []
synonym: "negative regulation of interleukin-7 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-7 formation" EXACT []
synonym: "negative regulation of interleukin-7 synthesis" EXACT []
is_a: GO:0032716 ! negative regulation of interleukin-7 production
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045411 ! regulation of interleukin-7 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042227 ! interleukin-7 biosynthetic process
relationship: negatively_regulates GO:0042227 ! interleukin-7 biosynthetic process

[Term]
id: GO:0045413
name: positive regulation of interleukin-7 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-7." [GOC:go_curators]
synonym: "activation of interleukin-7 biosynthetic process" NARROW []
synonym: "positive regulation of IL-7 biosynthesis" EXACT []
synonym: "positive regulation of IL-7 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-7 anabolism" EXACT []
synonym: "positive regulation of interleukin-7 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-7 formation" EXACT []
synonym: "positive regulation of interleukin-7 synthesis" EXACT []
synonym: "stimulation of interleukin-7 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-7 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-7 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-7 biosynthetic process" EXACT []
is_a: GO:0032756 ! positive regulation of interleukin-7 production
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045411 ! regulation of interleukin-7 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042227 ! interleukin-7 biosynthetic process
relationship: positively_regulates GO:0042227 ! interleukin-7 biosynthetic process

[Term]
id: GO:0045414
name: regulation of interleukin-8 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-8." [GOC:go_curators]
synonym: "regulation of IL-8 biosynthesis" EXACT []
synonym: "regulation of IL-8 biosynthetic process" EXACT []
synonym: "regulation of interleukin-8 anabolism" EXACT []
synonym: "regulation of interleukin-8 biosynthesis" EXACT []
synonym: "regulation of interleukin-8 formation" EXACT []
synonym: "regulation of interleukin-8 synthesis" EXACT []
is_a: GO:0032677 ! regulation of interleukin-8 production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042228 ! interleukin-8 biosynthetic process
relationship: regulates GO:0042228 ! interleukin-8 biosynthetic process

[Term]
id: GO:0045415
name: negative regulation of interleukin-8 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-8." [GOC:go_curators]
synonym: "down regulation of interleukin-8 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-8 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-8 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-8 biosynthetic process" NARROW []
synonym: "negative regulation of IL-8 biosynthesis" EXACT []
synonym: "negative regulation of IL-8 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-8 anabolism" EXACT []
synonym: "negative regulation of interleukin-8 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-8 formation" EXACT []
synonym: "negative regulation of interleukin-8 synthesis" EXACT []
is_a: GO:0032717 ! negative regulation of interleukin-8 production
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045414 ! regulation of interleukin-8 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042228 ! interleukin-8 biosynthetic process
relationship: negatively_regulates GO:0042228 ! interleukin-8 biosynthetic process

[Term]
id: GO:0045416
name: positive regulation of interleukin-8 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-8." [GOC:go_curators]
synonym: "activation of interleukin-8 biosynthetic process" NARROW []
synonym: "positive regulation of IL-8 biosynthesis" EXACT []
synonym: "positive regulation of IL-8 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-8 anabolism" EXACT []
synonym: "positive regulation of interleukin-8 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-8 formation" EXACT []
synonym: "positive regulation of interleukin-8 synthesis" EXACT []
synonym: "stimulation of interleukin-8 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-8 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-8 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-8 biosynthetic process" EXACT []
is_a: GO:0032757 ! positive regulation of interleukin-8 production
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045414 ! regulation of interleukin-8 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042228 ! interleukin-8 biosynthetic process
relationship: positively_regulates GO:0042228 ! interleukin-8 biosynthetic process

[Term]
id: GO:0045417
name: regulation of interleukin-9 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-9." [GOC:go_curators]
synonym: "regulation of IL-9 biosynthesis" EXACT []
synonym: "regulation of IL-9 biosynthetic process" EXACT []
synonym: "regulation of interleukin-9 anabolism" EXACT []
synonym: "regulation of interleukin-9 biosynthesis" EXACT []
synonym: "regulation of interleukin-9 formation" EXACT []
synonym: "regulation of interleukin-9 synthesis" EXACT []
is_a: GO:0032678 ! regulation of interleukin-9 production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042229 ! interleukin-9 biosynthetic process
relationship: regulates GO:0042229 ! interleukin-9 biosynthetic process

[Term]
id: GO:0045418
name: negative regulation of interleukin-9 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-9." [GOC:go_curators]
synonym: "down regulation of interleukin-9 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-9 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-9 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-9 biosynthetic process" NARROW []
synonym: "negative regulation of IL-9 biosynthesis" EXACT []
synonym: "negative regulation of IL-9 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-9 anabolism" EXACT []
synonym: "negative regulation of interleukin-9 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-9 formation" EXACT []
synonym: "negative regulation of interleukin-9 synthesis" EXACT []
is_a: GO:0032718 ! negative regulation of interleukin-9 production
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045417 ! regulation of interleukin-9 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042229 ! interleukin-9 biosynthetic process
relationship: negatively_regulates GO:0042229 ! interleukin-9 biosynthetic process

[Term]
id: GO:0045419
name: positive regulation of interleukin-9 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-9." [GOC:go_curators]
synonym: "activation of interleukin-9 biosynthetic process" NARROW []
synonym: "positive regulation of IL-9 biosynthesis" EXACT []
synonym: "positive regulation of IL-9 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-9 anabolism" EXACT []
synonym: "positive regulation of interleukin-9 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-9 formation" EXACT []
synonym: "positive regulation of interleukin-9 synthesis" EXACT []
synonym: "stimulation of interleukin-9 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-9 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-9 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-9 biosynthetic process" EXACT []
is_a: GO:0032758 ! positive regulation of interleukin-9 production
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045417 ! regulation of interleukin-9 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042229 ! interleukin-9 biosynthetic process
relationship: positively_regulates GO:0042229 ! interleukin-9 biosynthetic process

[Term]
id: GO:0045420
name: regulation of connective tissue growth factor biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of connective tissue growth factor." [GOC:go_curators]
synonym: "regulation of connective tissue growth factor anabolism" EXACT []
synonym: "regulation of connective tissue growth factor biosynthesis" EXACT []
synonym: "regulation of connective tissue growth factor formation" EXACT []
synonym: "regulation of connective tissue growth factor synthesis" EXACT []
is_a: GO:0032643 ! regulation of connective tissue growth factor production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045189 ! connective tissue growth factor biosynthetic process
relationship: regulates GO:0045189 ! connective tissue growth factor biosynthetic process

[Term]
id: GO:0045421
name: negative regulation of connective tissue growth factor biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of connective tissue growth factor." [GOC:go_curators]
synonym: "down regulation of connective tissue growth factor biosynthetic process" EXACT []
synonym: "down-regulation of connective tissue growth factor biosynthetic process" EXACT []
synonym: "downregulation of connective tissue growth factor biosynthetic process" EXACT []
synonym: "inhibition of connective tissue growth factor biosynthetic process" NARROW []
synonym: "negative regulation of connective tissue growth factor anabolism" EXACT []
synonym: "negative regulation of connective tissue growth factor biosynthesis" EXACT []
synonym: "negative regulation of connective tissue growth factor formation" EXACT []
synonym: "negative regulation of connective tissue growth factor synthesis" EXACT []
is_a: GO:0032683 ! negative regulation of connective tissue growth factor production
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045420 ! regulation of connective tissue growth factor biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045189 ! connective tissue growth factor biosynthetic process
relationship: negatively_regulates GO:0045189 ! connective tissue growth factor biosynthetic process

[Term]
id: GO:0045422
name: positive regulation of connective tissue growth factor biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of connective tissue growth factor." [GOC:go_curators]
synonym: "activation of connective tissue growth factor biosynthetic process" NARROW []
synonym: "positive regulation of connective tissue growth factor anabolism" EXACT []
synonym: "positive regulation of connective tissue growth factor biosynthesis" EXACT []
synonym: "positive regulation of connective tissue growth factor formation" EXACT []
synonym: "positive regulation of connective tissue growth factor synthesis" EXACT []
synonym: "stimulation of connective tissue growth factor biosynthetic process" NARROW []
synonym: "up regulation of connective tissue growth factor biosynthetic process" EXACT []
synonym: "up-regulation of connective tissue growth factor biosynthetic process" EXACT []
synonym: "upregulation of connective tissue growth factor biosynthetic process" EXACT []
is_a: GO:0032723 ! positive regulation of connective tissue growth factor production
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045420 ! regulation of connective tissue growth factor biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045189 ! connective tissue growth factor biosynthetic process
relationship: positively_regulates GO:0045189 ! connective tissue growth factor biosynthetic process

[Term]
id: GO:0045423
name: regulation of granulocyte macrophage colony-stimulating factor biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of granulocyte macrophage colony-stimulating factor." [GOC:go_curators]
synonym: "regulation of GM-CSF biosynthesis" EXACT [GOC:vk]
synonym: "regulation of granulocyte macrophage colony stimulating factor biosynthetic process" EXACT []
synonym: "regulation of granulocyte macrophage colony-stimulating factor anabolism" EXACT []
synonym: "regulation of granulocyte macrophage colony-stimulating factor biosynthesis" EXACT []
synonym: "regulation of granulocyte macrophage colony-stimulating factor formation" EXACT []
synonym: "regulation of granulocyte macrophage colony-stimulating factor synthesis" EXACT []
is_a: GO:0032645 ! regulation of granulocyte macrophage colony-stimulating factor production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042253 ! granulocyte macrophage colony-stimulating factor biosynthetic process
relationship: regulates GO:0042253 ! granulocyte macrophage colony-stimulating factor biosynthetic process

[Term]
id: GO:0045424
name: negative regulation of granulocyte macrophage colony-stimulating factor biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of granulocyte macrophage colony-stimulating factor." [GOC:go_curators]
synonym: "down regulation of granulocyte macrophage colony-stimulating factor biosynthetic process" EXACT []
synonym: "down-regulation of granulocyte macrophage colony-stimulating factor biosynthetic process" EXACT []
synonym: "downregulation of granulocyte macrophage colony-stimulating factor biosynthetic process" EXACT []
synonym: "inhibition of granulocyte macrophage colony-stimulating factor biosynthetic process" NARROW []
synonym: "negative regulation of GM-CSF biosynthesis" EXACT [GOC:vk]
synonym: "negative regulation of granulocyte macrophage colony stimulating factor biosynthetic process" EXACT []
synonym: "negative regulation of granulocyte macrophage colony-stimulating factor anabolism" EXACT []
synonym: "negative regulation of granulocyte macrophage colony-stimulating factor biosynthesis" EXACT []
synonym: "negative regulation of granulocyte macrophage colony-stimulating factor formation" EXACT []
synonym: "negative regulation of granulocyte macrophage colony-stimulating factor synthesis" EXACT []
is_a: GO:0032685 ! negative regulation of granulocyte macrophage colony-stimulating factor production
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045423 ! regulation of granulocyte macrophage colony-stimulating factor biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042253 ! granulocyte macrophage colony-stimulating factor biosynthetic process
relationship: negatively_regulates GO:0042253 ! granulocyte macrophage colony-stimulating factor biosynthetic process

[Term]
id: GO:0045425
name: positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of granulocyte macrophage colony-stimulating factor." [GOC:go_curators]
synonym: "activation of granulocyte macrophage colony-stimulating factor biosynthetic process" NARROW []
synonym: "positive regulation of GM-CSF biosynthesis" RELATED [GOC:vk]
synonym: "positive regulation of granulocyte macrophage colony stimulating factor biosynthetic process" EXACT []
synonym: "positive regulation of granulocyte macrophage colony-stimulating factor anabolism" EXACT []
synonym: "positive regulation of granulocyte macrophage colony-stimulating factor biosynthesis" EXACT []
synonym: "positive regulation of granulocyte macrophage colony-stimulating factor formation" EXACT []
synonym: "positive regulation of granulocyte macrophage colony-stimulating factor synthesis" EXACT []
synonym: "stimulation of granulocyte macrophage colony-stimulating factor biosynthetic process" NARROW []
synonym: "up regulation of granulocyte macrophage colony-stimulating factor biosynthetic process" EXACT []
synonym: "up-regulation of granulocyte macrophage colony-stimulating factor biosynthetic process" EXACT []
synonym: "upregulation of granulocyte macrophage colony-stimulating factor biosynthetic process" EXACT []
is_a: GO:0032725 ! positive regulation of granulocyte macrophage colony-stimulating factor production
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045423 ! regulation of granulocyte macrophage colony-stimulating factor biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042253 ! granulocyte macrophage colony-stimulating factor biosynthetic process
relationship: positively_regulates GO:0042253 ! granulocyte macrophage colony-stimulating factor biosynthetic process

[Term]
id: GO:0045427
name: enzyme active site formation via (phospho-5'-guanosine)-L-histidine
namespace: biological_process
def: "The transient guanylylation of peptidyl-histidine to form (phospho-5'-guanosine)-L-histidine." [RESID:AA0325]
subset: gosubset_prok
is_a: GO:0018307 ! enzyme active site formation
is_a: GO:0098825 ! peptidyl-histidine guanylation

[Term]
id: GO:0045428
name: regulation of nitric oxide biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide." [GOC:go_curators]
synonym: "regulation of nitric oxide anabolism" EXACT []
synonym: "regulation of nitric oxide biosynthesis" EXACT []
synonym: "regulation of nitric oxide formation" EXACT []
synonym: "regulation of nitric oxide synthesis" EXACT []
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
is_a: GO:1903426 ! regulation of reactive oxygen species biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006809 ! nitric oxide biosynthetic process
relationship: regulates GO:0006809 ! nitric oxide biosynthetic process

[Term]
id: GO:0045429
name: positive regulation of nitric oxide biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide." [GOC:go_curators]
synonym: "activation of nitric oxide biosynthetic process" NARROW []
synonym: "positive regulation of nitric oxide anabolism" EXACT []
synonym: "positive regulation of nitric oxide biosynthesis" EXACT []
synonym: "positive regulation of nitric oxide formation" EXACT []
synonym: "positive regulation of nitric oxide synthesis" EXACT []
synonym: "stimulation of nitric oxide biosynthetic process" NARROW []
synonym: "up regulation of nitric oxide biosynthetic process" EXACT []
synonym: "up-regulation of nitric oxide biosynthetic process" EXACT []
synonym: "upregulation of nitric oxide biosynthetic process" EXACT []
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0045428 ! regulation of nitric oxide biosynthetic process
is_a: GO:1903428 ! positive regulation of reactive oxygen species biosynthetic process
is_a: GO:1904407 ! positive regulation of nitric oxide metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006809 ! nitric oxide biosynthetic process
relationship: positively_regulates GO:0006809 ! nitric oxide biosynthetic process

[Term]
id: GO:0045430
name: chalcone isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: a chalcone = a flavanone." [EC:5.5.1.6]
synonym: "chalcone--flavonone isomerase activity" EXACT [EC:5.5.1.6]
synonym: "chalcone-flavanone isomerase activity" EXACT []
synonym: "flavanone lyase (decyclizing)" EXACT [EC:5.5.1.6]
xref: EC:5.5.1.6
xref: MetaCyc:CHALCONE-ISOMERASE-RXN
is_a: GO:0016872 ! intramolecular lyase activity

[Term]
id: GO:0045431
name: flavonol synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: a dihydroflavonol + 2-oxoglurate + O2 = a flavonol + succinate + CO2 + H2O." [EC:1.14.11.23, ISBN:0943088372, PMID:7904213]
synonym: "dihydroflavonol,2-oxoglutarate:oxygen oxidoreductase activity" EXACT [EC:1.14.11.23]
synonym: "flavonoid 2-oxoglutarate-dependent dioxygenase activity" EXACT [EC:1.14.11.23]
synonym: "FLS activity" RELATED [EC:1.14.11.23]
xref: EC:1.14.11.23
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
relationship: part_of GO:0051555 ! flavonol biosynthetic process

[Term]
id: GO:0045433
name: male courtship behavior, veined wing generated song production
namespace: biological_process
def: "The process during wing vibration where the male insect produces a species-specific acoustic signal called a love song." [GOC:mtg_sensu, PMID:11092827]
synonym: "male courtship behavior, song production" BROAD []
synonym: "male courtship behaviour, song production" BROAD []
synonym: "male courtship behaviour, veined wing generated song production" EXACT []
is_a: GO:0008049 ! male courtship behavior
relationship: part_of GO:0016545 ! male courtship behavior, veined wing vibration

[Term]
id: GO:0045434
name: negative regulation of female receptivity, post-mating
namespace: biological_process
def: "Any process that stops, prevents or reduces the receptiveness of a female to male advances subsequent to mating." [GOC:bf, PMID:11092827]
synonym: "down regulation of female receptivity, post-mating" EXACT []
synonym: "down-regulation of female receptivity, post-mating" EXACT []
synonym: "downregulation of female receptivity, post-mating" EXACT []
synonym: "inhibition of female receptivity, post-mating" NARROW []
is_a: GO:0007621 ! negative regulation of female receptivity
is_a: GO:0046008 ! regulation of female receptivity, post-mating

[Term]
id: GO:0045435
name: lycopene epsilon cyclase activity
namespace: molecular_function
def: "Catalysis of the cyclization of an epsilon ring at one end of the lycopene molecule (psi, psi-carotene) to form delta-carotene (epsilon, psi-carotene)." [PMID:8837512]
synonym: "lycopene cyclase" BROAD []
is_a: GO:0009975 ! cyclase activity
is_a: GO:0016860 ! intramolecular oxidoreductase activity

[Term]
id: GO:0045436
name: lycopene beta cyclase activity
namespace: molecular_function
def: "Catalysis of the cyclization of beta rings at one or both ends of the lycopene molecule (psi, psi-carotene) to form gamma-carotene or the bicyclic beta-carotene (beta, beta-carotene), respectively." [PMID:8837512]
subset: gosubset_prok
synonym: "crtL" RELATED []
synonym: "lycopene cyclase" BROAD []
xref: MetaCyc:RXN1F-150
is_a: GO:0009975 ! cyclase activity
is_a: GO:0016860 ! intramolecular oxidoreductase activity

[Term]
id: GO:0045437
name: uridine nucleosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + uridine = ribofuranose + uracil." [EC:3.2.2.3, RHEA:15580]
subset: gosubset_prok
synonym: "uridine hydrolase activity" EXACT []
synonym: "uridine ribohydrolase activity" EXACT [EC:3.2.2.3]
xref: EC:3.2.2.3
xref: KEGG:R01080
xref: MetaCyc:URIDINE-NUCLEOSIDASE-RXN
xref: RHEA:15580
is_a: GO:0050263 ! ribosylpyrimidine nucleosidase activity

[Term]
id: GO:0045438
name: delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase activity
namespace: molecular_function
def: "Catalysis of the formation of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine from constituent amino acids and ATP in the presence of magnesium ions and dithioerythritol." [PMID:1572368, PMID:2061333]
synonym: "ACV synthetase activity" BROAD []
is_a: GO:0016874 ! ligase activity

[Term]
id: GO:0045439
name: isopenicillin-N epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: isopenicillin N = penicillin N." [EC:5.1.1.17, RHEA:20036]
subset: gosubset_prok
synonym: "isopenicillin N epimerase activity" EXACT []
synonym: "penicillin-N 5-amino-5-carboxypentanoyl-epimerase activity" EXACT [EC:5.1.1.17]
xref: EC:5.1.1.17
xref: KEGG:R04147
xref: MetaCyc:5.1.1.17-RXN
xref: RHEA:20036
is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives

[Term]
id: GO:0045442
name: deacetoxycephalosporin-C hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + deacetoxycephalosporin C + O(2) = CO(2) + deacetylcephalosporin C + succinate." [EC:1.14.11.26, RHEA:16808]
synonym: "3'-methylcephem hydroxylase activity" EXACT [EC:1.14.11.26]
synonym: "beta-lactam hydroxylase activity" EXACT []
synonym: "DACS" RELATED [EC:1.14.11.26]
synonym: "DAOC hydroxylase activity" EXACT [EC:1.14.11.26]
synonym: "deacetoxycephalosporin C hydroxylase activity" EXACT [EC:1.14.11.26]
synonym: "deacetoxycephalosporin-C,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.11.26]
synonym: "deacetylcephalosporin C synthase activity" EXACT [EC:1.14.11.26]
xref: EC:1.14.11.26
xref: KEGG:R05229
xref: MetaCyc:1.14.11.26-RXN
xref: RHEA:16808
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0045443
name: juvenile hormone secretion
namespace: biological_process
def: "The regulated release of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:go_curators, ISBN:0198547684]
is_a: GO:0046865 ! terpenoid transport
is_a: GO:0060986 ! endocrine hormone secretion

[Term]
id: GO:0045444
name: fat cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat." [CL:0000136, GOC:go_curators]
synonym: "adipocyte cell differentiation" EXACT []
synonym: "adipocyte differentiation" EXACT []
synonym: "adipogenesis" RELATED []
synonym: "adipose cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0045445
name: myoblast differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers." [CL:0000056, GOC:go_curators, GOC:mtg_muscle]
synonym: "myoblast cell differentiation" EXACT []
is_a: GO:0042692 ! muscle cell differentiation

[Term]
id: GO:0045446
name: endothelial cell differentiation
namespace: biological_process
def: "The process in which a mesodermal, bone marrow or neural crest cell acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium." [CL:0000115, GOC:go_curators]
is_a: GO:0030855 ! epithelial cell differentiation
relationship: part_of GO:0003158 ! endothelium development

[Term]
id: GO:0045448
name: mitotic cell cycle, embryonic
namespace: biological_process
def: "The eukaryotic cell cycle in which a cell is duplicated without changing ploidy, occurring in the embryo." [GOC:go_curators]
is_a: GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0009790 ! embryo development

[Term]
id: GO:0045450
name: bicoid mRNA localization
namespace: biological_process
def: "Any process in which bicoid mRNA is transported to and maintained within the oocyte as part of the specification of the anterior/posterior axis." [GOC:go_curators]
synonym: "bicoid mRNA localisation" EXACT [GOC:mah]
synonym: "establishment and maintenance of bicoid mRNA localization" EXACT []
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0060811 ! intracellular mRNA localization involved in anterior/posterior axis specification
is_a: GO:1902580 ! single-organism cellular localization
relationship: part_of GO:0007314 ! oocyte anterior/posterior axis specification

[Term]
id: GO:0045451
name: pole plasm oskar mRNA localization
namespace: biological_process
def: "Any process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators]
synonym: "establishment and maintenance of oskar mRNA localization in pole plasm" EXACT []
synonym: "establishment and maintenance of pole plasm oskar mRNA localization" EXACT []
synonym: "oocyte pole plasm oskar mRNA localization" EXACT []
synonym: "pole plasm oskar mRNA localisation" EXACT [GOC:mah]
is_a: GO:0019094 ! pole plasm mRNA localization

[Term]
id: GO:0045453
name: bone resorption
namespace: biological_process
def: "The process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products." [GOC:mah, PMID:10968780]
xref: Wikipedia:Bone_resorption
is_a: GO:0001894 ! tissue homeostasis
relationship: part_of GO:0046849 ! bone remodeling

[Term]
id: GO:0045454
name: cell redox homeostasis
namespace: biological_process
alt_id: GO:0030503
alt_id: GO:0045867
alt_id: GO:0045868
def: "Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]
subset: gosubset_prok
synonym: "regulation of cell redox homeostasis" RELATED []
synonym: "regulation of redox homeostasis" BROAD []
is_a: GO:0019725 ! cellular homeostasis
is_a: GO:0050794 ! regulation of cellular process

[Term]
id: GO:0045455
name: ecdysteroid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ecdysteroids, a group of polyhydroxylated ketosteroids ubiquitous in insects and other arthropods, in which they initiate post-embryonic development, including the metamorphosis of immature forms and the development of the reproductive system and the maturation of oocytes in adult females." [ISBN:0198506732]
synonym: "ecdysteroid metabolism" EXACT []
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:0034754 ! cellular hormone metabolic process
is_a: GO:0042180 ! cellular ketone metabolic process
relationship: part_of GO:0002165 ! instar larval or pupal development

[Term]
id: GO:0045456
name: ecdysteroid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development." [GOC:go_curators]
synonym: "ecdysteroid anabolism" EXACT []
synonym: "ecdysteroid biosynthesis" EXACT []
synonym: "ecdysteroid formation" EXACT []
synonym: "ecdysteroid synthesis" EXACT []
is_a: GO:0006694 ! steroid biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0042446 ! hormone biosynthetic process
is_a: GO:0045455 ! ecdysteroid metabolic process

[Term]
id: GO:0045457
name: ecdysteroid secretion
namespace: biological_process
def: "The regulated release of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development." [GOC:go_curators]
is_a: GO:0035929 ! steroid hormone secretion

[Term]
id: GO:0045458
name: recombination within rDNA repeats
namespace: biological_process
def: "Genetic recombination within the DNA of the genes coding for ribosomal RNA." [GOC:go_curators, ISBN:0198506732]
comment: Note that this term was reinstated from obsolete.
subset: gosubset_prok
synonym: "recombination within ribosomal DNA repeats" EXACT []
is_a: GO:0006310 ! DNA recombination
is_a: GO:0043007 ! maintenance of rDNA

[Term]
id: GO:0045459
name: iron incorporation into iron-sulfur cluster via tetrakis-L-cysteinyl triiron tetrasulfide
namespace: biological_process
def: "The incorporation of iron into a 3Fe-4S iron-sulfur cluster via tetrakis-L-cysteinyl triiron tetrasulfide." [PMID:11592901, RESID:AA0326]
subset: gosubset_prok
synonym: "iron incorporation into iron-sulphur cluster via tetrakis-L-cysteinyl triiron tetrasulphide" EXACT []
xref: RESID:AA0326
is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster

[Term]
id: GO:0045460
name: sterigmatocystin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds." [CHEBI:18227, GOC:go_curators]
subset: gosubset_prok
synonym: "sterigmatocystin metabolism" EXACT []
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0009404 ! toxin metabolic process
is_a: GO:1901376 ! organic heteropentacyclic compound metabolic process

[Term]
id: GO:0045461
name: sterigmatocystin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds." [CHEBI:18227, GOC:go_curators]
subset: gosubset_prok
synonym: "sterigmatocystin anabolism" EXACT []
synonym: "sterigmatocystin biosynthesis" EXACT []
synonym: "sterigmatocystin formation" EXACT []
synonym: "sterigmatocystin synthesis" EXACT []
is_a: GO:0009403 ! toxin biosynthetic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0045460 ! sterigmatocystin metabolic process
is_a: GO:1901378 ! organic heteropentacyclic compound biosynthetic process

[Term]
id: GO:0045462
name: trichothecene 3-O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the 3-O-acetylation of a trichothecene. Trichothecenes are sesquiterpene epoxide mycotoxins that act as potent inhibitors of eukaryotic protein synthesis." [PMID:10583973]
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0045463
name: R8 cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of the R8 photoreceptor over time, from its formation to the mature structure. The R8 photoreceptor is the founding receptor of each ommatidium." [PMID:11880339]
is_a: GO:0042051 ! compound eye photoreceptor development
relationship: part_of GO:0045465 ! R8 cell differentiation

[Term]
id: GO:0045464
name: R8 cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into an R8 cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [PMID:11880339]
is_a: GO:0043704 ! photoreceptor cell fate specification
relationship: part_of GO:0007460 ! R8 cell fate commitment

[Term]
id: GO:0045465
name: R8 cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of the R8 photoreceptor." [PMID:11880339]
is_a: GO:0001751 ! compound eye photoreceptor cell differentiation

[Term]
id: GO:0045466
name: R7 cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of the R7 photoreceptor." [PMID:11880339]
is_a: GO:0001751 ! compound eye photoreceptor cell differentiation

[Term]
id: GO:0045467
name: R7 cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of the R7 photoreceptor over time, from its formation to the mature structure. The R7 photoreceptor is the last photoreceptor to develop in the ommatidium." [PMID:11880339]
is_a: GO:0042051 ! compound eye photoreceptor development
relationship: part_of GO:0045466 ! R7 cell differentiation

[Term]
id: GO:0045468
name: regulation of R8 cell spacing in compound eye
namespace: biological_process
def: "Any process that ensures that the R8 cells are selected in a precise progressive pattern so that they are evenly spaced throughout the eye disc." [GOC:dph, GOC:tb, PMID:11880339]
synonym: "R8 cell spacing in compound eye" RELATED [GOC:dph, GOC:tb]
synonym: "regulation of R8 spacing" EXACT [GOC:dph]
is_a: GO:0007389 ! pattern specification process
is_a: GO:0065008 ! regulation of biological quality
relationship: part_of GO:0048749 ! compound eye development

[Term]
id: GO:0045469
name: negative regulation of R8 cell spacing in compound eye
namespace: biological_process
def: "Any process that stops or prevents the correct R8 cell spacing pattern in a compound eye." [GOC:dph, GOC:tb, PMID:11880339]
synonym: "down regulation of R8 spacing" EXACT []
synonym: "down-regulation of R8 spacing" EXACT []
synonym: "downregulation of R8 spacing" EXACT []
synonym: "inhibition of R8 spacing" NARROW []
is_a: GO:0045468 ! regulation of R8 cell spacing in compound eye

[Term]
id: GO:0045470
name: R8 cell-mediated photoreceptor organization
namespace: biological_process
def: "The regionalization process that coordinates the recruitment and organization of other non-R8 photoreceptors by the R8 photoreceptor." [PMID:11880339]
synonym: "R8-mediated photoreceptor organisation" EXACT [GOC:curators]
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0042051 ! compound eye photoreceptor development

[Term]
id: GO:0045471
name: response to ethanol
namespace: biological_process
alt_id: GO:0017036
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus." [GOC:go_curators]
is_a: GO:0097305 ! response to alcohol

[Term]
id: GO:0045472
name: response to ether
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ether stimulus." [GOC:go_curators]
is_a: GO:0010033 ! response to organic substance
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0045473
name: obsolete response to ethanol (sensu Insecta)
namespace: biological_process
def: "OBSOLETE. A change in state or activity of an insect (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus." [GOC:go_curators, GOC:jid]
comment: This term was made obsolete because there is no clear difference between the sensu Insecta term and the generic term.
synonym: "response to ethanol (sensu Insecta)" EXACT []
is_obsolete: true
consider: GO:0048149

[Term]
id: GO:0045474
name: obsolete response to ether (sensu Insecta)
namespace: biological_process
def: "OBSOLETE. A change in state or activity of an insect (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ether stimulus." [GOC:go_curators, GOC:jid]
comment: This term was made obsolete because there is no clear difference between the sensu Insecta term and the generic term.
synonym: "response to ether (sensu Insecta)" EXACT []
is_obsolete: true
consider: GO:0048150

[Term]
id: GO:0045475
name: locomotor rhythm
namespace: biological_process
def: "The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators]
synonym: "circadian locomotor activity rhythm" NARROW []
is_a: GO:0007626 ! locomotory behavior
is_a: GO:0044708 ! single-organism behavior
is_a: GO:0048512 ! circadian behavior

[Term]
id: GO:0045476
name: nurse cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a nurse cell. During late oogenesis, following the transfer of substances from the nurse cells to the oocyte, nurse cell remnants are cleared from the egg chamber by apoptotic process." [CL:0000026, GOC:mtg_apoptosis, PMID:11973306]
synonym: "apoptosis of nurse cells" EXACT []
synonym: "invertebrate nurse cell apoptosis" NARROW []
synonym: "nurse cell apoptosis" NARROW []
synonym: "nurse cell programmed cell death by apoptosis" EXACT []
synonym: "programmed cell death of nurse cells by apoptosis" EXACT []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0010623 ! developmental programmed cell death
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:1902742 ! apoptotic process involved in development
relationship: part_of GO:0048477 ! oogenesis

[Term]
id: GO:0045477
name: regulation of nurse cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nurse cell apoptotic process." [GOC:mtg_apoptosis, PMID:11973306]
synonym: "regulation of nurse cell apoptosis" NARROW []
is_a: GO:0043900 ! regulation of multi-organism process
is_a: GO:0051239 ! regulation of multicellular organismal process
is_a: GO:0060284 ! regulation of cell development
is_a: GO:1904748 ! regulation of apoptotic process involved in development
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045476 ! nurse cell apoptotic process
relationship: regulates GO:0045476 ! nurse cell apoptotic process

[Term]
id: GO:0045478
name: fusome organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome, a large intracellular spectrin-rich structure found in insect germline cells and mammalian hematopoietic cells." [GOC:dph, GOC:go_curators, GOC:jl, GOC:mah]
subset: goslim_pir
synonym: "fusome organisation" EXACT [GOC:curators]
synonym: "fusome organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization
is_a: GO:0022414 ! reproductive process
relationship: part_of GO:0032504 ! multicellular organism reproduction

[Term]
id: GO:0045479
name: vesicle targeting to fusome
namespace: biological_process
def: "The recruitment of vesicles to the fusome. The vesicles become the fusome tubule network and are necessary for the assembly of the fusome." [PMID:9046244]
synonym: "vesicle-fusome targeting" EXACT []
is_a: GO:0006903 ! vesicle targeting
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
relationship: part_of GO:0045478 ! fusome organization

[Term]
id: GO:0045480
name: galactose oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-galactose + O2 = D-galacto-hexodialdose + hydrogen peroxide." [EC:1.1.3.9]
synonym: "beta-galactose oxidase activity" RELATED [EC:1.1.3.9]
synonym: "D-galactose oxidase activity" EXACT [EC:1.1.3.9]
synonym: "D-galactose:oxygen 6-oxidoreductase activity" EXACT [EC:1.1.3.9]
xref: EC:1.1.3.9
xref: MetaCyc:GALACTOSE-OXIDASE-RXN
xref: RHEA:24163
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0045481
name: 6-endo-hydroxycineole dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-endo-hydroxycineole + NAD(+) = 6-oxocineole + H(+) + NADH." [EC:1.1.1.241, RHEA:11739]
synonym: "6-endo-hydroxycineole:NAD+ 6-oxidoreductase activity" EXACT [EC:1.1.1.241]
xref: EC:1.1.1.241
xref: KEGG:R02994
xref: MetaCyc:6-ENDO-HYDROXYCINEOLE-DEHYDROGENASE-RXN
xref: RHEA:11739
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0045482
name: trichodiene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + trichodiene." [EC:4.2.3.6, RHEA:12055]
synonym: "sesquiterpene cyclase activity" BROAD [EC:4.2.3.6]
synonym: "trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, trichodiene-forming)" EXACT [EC:4.2.3.6]
synonym: "trans,trans-farnesyl-diphosphate sesquiterpenoid-lyase activity" EXACT [EC:4.2.3.6]
synonym: "trichodiene synthetase activity" EXACT [EC:4.2.3.6]
xref: EC:4.2.3.6
xref: KEGG:R02306
xref: MetaCyc:TRICHODIENE-SYNTHASE-RXN
xref: RHEA:12055
is_a: GO:0010334 ! sesquiterpene synthase activity

[Term]
id: GO:0045483
name: aristolochene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans,trans-farnesyl diphosphate = aristolochene + diphosphate." [EC:4.2.3.9]
synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, aristolochene-forming)" EXACT [EC:4.2.3.9]
synonym: "5-epi-aristolochene synthase activity" EXACT [EC:4.2.3.9]
synonym: "sesquiterpene cyclase activity" BROAD [EC:4.2.3.9]
synonym: "trans,trans-farnesyl diphosphate aristolochene-lyase activity" EXACT [EC:4.2.3.9]
synonym: "trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, aristolochene-forming)" EXACT [EC:4.2.3.9]
xref: EC:4.2.3.9
xref: MetaCyc:ARISTOLOCHENE-SYNTHASE-RXN
xref: RHEA:19828
is_a: GO:0010334 ! sesquiterpene synthase activity

[Term]
id: GO:0045484
name: L-lysine 6-transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + L-lysine = L-glutamate + allysine." [EC:2.6.1.36, RHEA:21203]
subset: gosubset_prok
synonym: "L-lysine aminotransferase activity" EXACT [EC:2.6.1.36]
synonym: "L-lysine transaminase activity" EXACT [EC:2.6.1.36]
synonym: "L-lysine-alpha-ketoglutarate 6-aminotransferase activity" EXACT [EC:2.6.1.36]
synonym: "L-lysine-alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.36]
synonym: "L-lysine:2-oxoglutarate 6-aminotransferase activity" EXACT [EC:2.6.1.36]
synonym: "lysine 6-aminotransferase activity" EXACT []
synonym: "lysine epsilon-aminotransferase activity" EXACT [EC:2.6.1.36]
synonym: "lysine epsilon-transaminase activity" EXACT [EC:2.6.1.36]
synonym: "lysine:2-ketoglutarate 6-aminotransferase activity" EXACT [EC:2.6.1.36]
xref: EC:2.6.1.36
xref: KEGG:R00457
xref: MetaCyc:L-LYSINE-AMINOTRANSFERASE-RXN
xref: RHEA:21203
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0045485
name: omega-6 fatty acid desaturase activity
namespace: molecular_function
def: "Catalysis of the introduction of an omega-6 double bond into the fatty acid hydrocarbon chain." [PMID:7846158]
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0045486
name: naringenin 3-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: naringenin + 2-oxoglutarate + O2 = dihydrokaempferol + succinate + CO2." [EC:1.14.11.9]
synonym: "(2S)-flavanone 3-hydroxylase activity" EXACT [EC:1.14.11.9]
synonym: "flavanone 3-beta-hydroxylase activity" EXACT [EC:1.14.11.9]
synonym: "flavanone 3-dioxygenase activity" EXACT [EC:1.14.11.9]
synonym: "flavanone 3-hydroxylase activity" EXACT [EC:1.14.11.9]
synonym: "flavanone 3beta-hydroxylase activity" EXACT [EC:1.14.11.9]
synonym: "flavanone synthase I activity" EXACT [EC:1.14.11.9]
synonym: "flavanone,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.11.9]
synonym: "naringenin 3-hydroxylase activity" EXACT [EC:1.14.11.9]
synonym: "naringenin,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.11.9]
xref: EC:1.14.11.9
xref: MetaCyc:NARINGENIN-3-DIOXYGENASE-RXN
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0045487
name: gibberellin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of gibberellin. Gibberellins are a class of highly modified terpenes that function as plant growth regulators." [GOC:go_curators]
subset: gosubset_prok
synonym: "gibberellic acid breakdown" NARROW []
synonym: "gibberellic acid catabolic process" NARROW []
synonym: "gibberellic acid catabolism" NARROW []
synonym: "gibberellic acid degradation" NARROW []
synonym: "gibberellin catabolism" EXACT []
is_a: GO:0009685 ! gibberellin metabolic process
is_a: GO:0016103 ! diterpenoid catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process

[Term]
id: GO:0045488
name: pectin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pectin, a group of galacturonic acid-containing, water-soluble colloidal carbohydrates of high molecular weight and of net negative charge." [GOC:tair_curators]
subset: gosubset_prok
synonym: "pectin metabolism" EXACT []
is_a: GO:0010393 ! galacturonan metabolic process

[Term]
id: GO:0045489
name: pectin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues." [GOC:go_curators, PMID:11931668]
subset: gosubset_prok
synonym: "pectin anabolism" EXACT []
synonym: "pectin biosynthesis" EXACT []
synonym: "pectin formation" EXACT []
synonym: "pectin synthesis" EXACT []
is_a: GO:0000271 ! polysaccharide biosynthetic process
is_a: GO:0045488 ! pectin metabolic process

[Term]
id: GO:0045490
name: pectin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues." [GOC:go_curators, PMID:11931668]
subset: gosubset_prok
synonym: "pectin breakdown" EXACT []
synonym: "pectin catabolism" EXACT []
synonym: "pectin degradation" EXACT []
is_a: GO:0000272 ! polysaccharide catabolic process
is_a: GO:0045488 ! pectin metabolic process

[Term]
id: GO:0045491
name: xylan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving xylan, a polymer containing a beta-1,4-linked D-xylose backbone." [GOC:go_curators, PMID:11931668]
subset: gosubset_prok
synonym: "xylan metabolism" EXACT []
is_a: GO:0010410 ! hemicellulose metabolic process

[Term]
id: GO:0045492
name: xylan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of xylan, a polymer containing a beta-1,4-linked D-xylose backbone." [GOC:go_curators, PMID:11931668]
subset: gosubset_prok
synonym: "xylan anabolism" EXACT []
synonym: "xylan biosynthesis" EXACT []
synonym: "xylan formation" EXACT []
synonym: "xylan synthesis" EXACT []
is_a: GO:0045491 ! xylan metabolic process
is_a: GO:0070592 ! cell wall polysaccharide biosynthetic process

[Term]
id: GO:0045493
name: xylan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of xylan, a polymer containing a beta-1,4-linked D-xylose backbone." [GOC:go_curators, PMID:11931668]
subset: gosubset_prok
synonym: "xylan breakdown" EXACT []
synonym: "xylan catabolism" EXACT []
synonym: "xylan degradation" EXACT []
is_a: GO:0000272 ! polysaccharide catabolic process
is_a: GO:0045491 ! xylan metabolic process

[Term]
id: GO:0045494
name: photoreceptor cell maintenance
namespace: biological_process
def: "Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light." [CL:0000210, GOC:bf, GOC:rl]
is_a: GO:0044707 ! single-multicellular organism process
relationship: part_of GO:0001895 ! retina homeostasis

[Term]
id: GO:0045495
name: pole plasm
namespace: cellular_component
def: "Differentiated cytoplasm associated with a pole (animal, vegetal, anterior, or posterior) of an oocyte, egg or early embryo." [GOC:kmv, PMID:17113380]
synonym: "germ plasm" NARROW []
synonym: "polar plasm" EXACT []
is_a: GO:0005737 ! cytoplasm

[Term]
id: GO:0045496
name: male analia development
namespace: biological_process
def: "The process whose specific outcome is the progression of the analia of the male over time, from formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11494318]
is_a: GO:0007487 ! analia development

[Term]
id: GO:0045497
name: female analia development
namespace: biological_process
def: "The process whose specific outcome is the progression of the analia of the female over time, from formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11494318]
is_a: GO:0007487 ! analia development

[Term]
id: GO:0045498
name: sex comb development
namespace: biological_process
def: "The process whose specific outcome is the progression of the sex comb over time, from its formation to the mature structure. The sex combs are the male specific chaetae located on the prothoracic tarsal segment of the prothoracic leg." [http://fly.ebi.ac.uk]
is_a: GO:0007423 ! sensory organ development

[Term]
id: GO:0045499
name: chemorepellent activity
namespace: molecular_function
def: "Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a lower concentration of that signal." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "chemorepellant activity" EXACT []
is_a: GO:0003674 ! molecular_function
relationship: part_of GO:0050919 ! negative chemotaxis

[Term]
id: GO:0045500
name: sevenless signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of an extracellular ligand to sevenless (sev; a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:signaling, PMID:10771085]
synonym: "sev receptor signaling pathway" EXACT []
synonym: "sev signaling pathway" EXACT []
synonym: "sevenless signalling pathway" EXACT []
is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway
relationship: part_of GO:0007465 ! R7 cell fate commitment

[Term]
id: GO:0045501
name: regulation of sevenless signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the sevenless signaling pathway." [GOC:go_curators]
synonym: "regulation of sev signaling pathway" EXACT []
synonym: "regulation of sevenless signalling pathway" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0010453 ! regulation of cell fate commitment
is_a: GO:0045676 ! regulation of R7 cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045500 ! sevenless signaling pathway
relationship: regulates GO:0045500 ! sevenless signaling pathway

[Term]
id: GO:0045502
name: dynein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with dynein, the multisubunit protein complex that is associated with microtubules." [GOC:bf]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0045503
name: dynein light chain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a light chain of the dynein complex." [GOC:bf]
is_a: GO:0045502 ! dynein binding

[Term]
id: GO:0045504
name: dynein heavy chain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a heavy chain of the dynein complex." [GOC:bf]
is_a: GO:0045502 ! dynein binding

[Term]
id: GO:0045505
name: dynein intermediate chain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an intermediate chain of the dynein complex." [GOC:bf]
is_a: GO:0045502 ! dynein binding

[Term]
id: GO:0045506
name: interleukin-24 receptor activity
namespace: molecular_function
def: "Combining with interleukin-24 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
synonym: "IL-24 receptor activity" EXACT [GOC:mah]
synonym: "IL-24R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity
relationship: has_part GO:0045510 ! interleukin-24 binding

[Term]
id: GO:0045507
name: interleukin-25 receptor activity
namespace: molecular_function
def: "Combining with interleukin-25 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
synonym: "IL-25 receptor activity" EXACT [GOC:mah]
synonym: "IL-25R" EXACT []
is_a: GO:0030368 ! interleukin-17 receptor activity
relationship: has_part GO:0045511 ! interleukin-25 binding

[Term]
id: GO:0045508
name: interleukin-26 receptor activity
namespace: molecular_function
def: "Combining with interleukin-26 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
synonym: "IL-26 receptor activity" EXACT [GOC:mah]
synonym: "IL-26R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity
relationship: has_part GO:0045512 ! interleukin-26 binding

[Term]
id: GO:0045509
name: interleukin-27 receptor activity
namespace: molecular_function
def: "Combining with interleukin-27 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
synonym: "IL-27 receptor activity" EXACT [GOC:mah]
synonym: "IL-27R" EXACT []
is_a: GO:0030368 ! interleukin-17 receptor activity
relationship: has_part GO:0045513 ! interleukin-27 binding
relationship: part_of GO:0070106 ! interleukin-27-mediated signaling pathway

[Term]
id: GO:0045510
name: interleukin-24 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-24." [GOC:go_curators]
synonym: "IL-24 binding" EXACT []
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0045511
name: interleukin-25 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-25." [GOC:go_curators]
synonym: "IL-25 binding" EXACT []
is_a: GO:0019975 ! interleukin-17 binding

[Term]
id: GO:0045512
name: interleukin-26 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-26." [GOC:go_curators]
synonym: "IL-26 binding" EXACT []
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0045513
name: interleukin-27 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-27." [GOC:go_curators]
synonym: "IL-27 binding" EXACT []
is_a: GO:0019975 ! interleukin-17 binding

[Term]
id: GO:0045514
name: interleukin-16 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-16 receptor." [GOC:go_curators]
synonym: "IL-16" NARROW []
synonym: "interleukin-16 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0045515
name: interleukin-18 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-18 receptor." [GOC:go_curators]
synonym: "IL-18" NARROW []
synonym: "interleukin-18 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0045516
name: interleukin-19 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-19 receptor." [GOC:go_curators]
synonym: "IL-19" NARROW []
synonym: "interleukin-19 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0045517
name: interleukin-20 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-20 receptor." [GOC:go_curators]
synonym: "IL-20" NARROW []
synonym: "interleukin-20 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0045518
name: interleukin-22 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-22 receptor." [GOC:go_curators]
synonym: "IL-22" NARROW []
synonym: "interleukin-22 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0045519
name: interleukin-23 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-23 receptor." [GOC:go_curators]
synonym: "IL-23" NARROW []
synonym: "interleukin-23 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0045520
name: interleukin-24 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-24 receptor." [GOC:go_curators]
synonym: "IL-24" NARROW []
synonym: "interleukin-24 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0045521
name: interleukin-25 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-25 receptor." [GOC:go_curators]
synonym: "IL-25" NARROW []
synonym: "interleukin-25 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0045522
name: interleukin-26 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-26 receptor." [GOC:go_curators]
synonym: "IL-26" NARROW []
synonym: "interleukin-26 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0045523
name: interleukin-27 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-27 receptor." [GOC:go_curators]
synonym: "IL-27" NARROW []
synonym: "interleukin-27 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0045524
name: interleukin-24 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-24." [GOC:go_curators]
synonym: "IL-24 biosynthesis" EXACT []
synonym: "IL-24 biosynthetic process" EXACT []
synonym: "interleukin-24 anabolism" EXACT []
synonym: "interleukin-24 biosynthesis" EXACT []
synonym: "interleukin-24 formation" EXACT []
synonym: "interleukin-24 synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032628 ! interleukin-24 production

[Term]
id: GO:0045525
name: interleukin-25 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-25." [GOC:go_curators]
synonym: "IL-25 biosynthesis" EXACT []
synonym: "IL-25 biosynthetic process" EXACT []
synonym: "interleukin-25 anabolism" EXACT []
synonym: "interleukin-25 biosynthesis" EXACT []
synonym: "interleukin-25 formation" EXACT []
synonym: "interleukin-25 synthesis" EXACT []
is_a: GO:0042235 ! interleukin-17 biosynthetic process
relationship: part_of GO:0032629 ! interleukin-25 production

[Term]
id: GO:0045526
name: interleukin-26 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-26." [GOC:go_curators]
synonym: "IL-26 biosynthesis" EXACT []
synonym: "IL-26 biosynthetic process" EXACT []
synonym: "interleukin-26 anabolism" EXACT []
synonym: "interleukin-26 biosynthesis" EXACT []
synonym: "interleukin-26 formation" EXACT []
synonym: "interleukin-26 synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032630 ! interleukin-26 production

[Term]
id: GO:0045527
name: interleukin-27 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-27." [GOC:go_curators]
synonym: "IL-27 biosynthesis" EXACT []
synonym: "IL-27 biosynthetic process" EXACT []
synonym: "interleukin-27 anabolism" EXACT []
synonym: "interleukin-27 biosynthesis" EXACT []
synonym: "interleukin-27 formation" EXACT []
synonym: "interleukin-27 synthesis" EXACT []
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032631 ! interleukin-27 production

[Term]
id: GO:0045528
name: regulation of interleukin-24 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-24." [GOC:go_curators]
synonym: "regulation of IL-24 biosynthesis" EXACT []
synonym: "regulation of IL-24 biosynthetic process" EXACT []
synonym: "regulation of interleukin-24 anabolism" EXACT []
synonym: "regulation of interleukin-24 biosynthesis" EXACT []
synonym: "regulation of interleukin-24 formation" EXACT []
synonym: "regulation of interleukin-24 synthesis" EXACT []
is_a: GO:0032668 ! regulation of interleukin-24 production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045524 ! interleukin-24 biosynthetic process
relationship: regulates GO:0045524 ! interleukin-24 biosynthetic process

[Term]
id: GO:0045529
name: regulation of interleukin-25 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-25." [GOC:go_curators]
synonym: "regulation of IL-25 biosynthesis" EXACT []
synonym: "regulation of IL-25 biosynthetic process" EXACT []
synonym: "regulation of interleukin-25 anabolism" EXACT []
synonym: "regulation of interleukin-25 biosynthesis" EXACT []
synonym: "regulation of interleukin-25 formation" EXACT []
synonym: "regulation of interleukin-25 synthesis" EXACT []
is_a: GO:0032669 ! regulation of interleukin-25 production
is_a: GO:0045378 ! regulation of interleukin-17 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045525 ! interleukin-25 biosynthetic process
relationship: regulates GO:0045525 ! interleukin-25 biosynthetic process

[Term]
id: GO:0045530
name: regulation of interleukin-26 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-26." [GOC:go_curators]
synonym: "regulation of IL-26 biosynthesis" EXACT []
synonym: "regulation of IL-26 biosynthetic process" EXACT []
synonym: "regulation of interleukin-26 anabolism" EXACT []
synonym: "regulation of interleukin-26 biosynthesis" EXACT []
synonym: "regulation of interleukin-26 formation" EXACT []
synonym: "regulation of interleukin-26 synthesis" EXACT []
is_a: GO:0032670 ! regulation of interleukin-26 production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045526 ! interleukin-26 biosynthetic process
relationship: regulates GO:0045526 ! interleukin-26 biosynthetic process

[Term]
id: GO:0045531
name: regulation of interleukin-27 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-27." [GOC:go_curators]
synonym: "regulation of IL-27 biosynthesis" EXACT []
synonym: "regulation of IL-27 biosynthetic process" EXACT []
synonym: "regulation of interleukin-27 anabolism" EXACT []
synonym: "regulation of interleukin-27 biosynthesis" EXACT []
synonym: "regulation of interleukin-27 formation" EXACT []
synonym: "regulation of interleukin-27 synthesis" EXACT []
is_a: GO:0032671 ! regulation of interleukin-27 production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045527 ! interleukin-27 biosynthetic process
relationship: regulates GO:0045527 ! interleukin-27 biosynthetic process

[Term]
id: GO:0045532
name: negative regulation of interleukin-24 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-24." [GOC:go_curators]
synonym: "down regulation of interleukin-24 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-24 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-24 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-24 biosynthetic process" NARROW []
synonym: "negative regulation of IL-24 biosynthesis" EXACT []
synonym: "negative regulation of IL-24 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-24 anabolism" EXACT []
synonym: "negative regulation of interleukin-24 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-24 formation" EXACT []
synonym: "negative regulation of interleukin-24 synthesis" EXACT []
is_a: GO:0032708 ! negative regulation of interleukin-24 production
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045528 ! regulation of interleukin-24 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045524 ! interleukin-24 biosynthetic process
relationship: negatively_regulates GO:0045524 ! interleukin-24 biosynthetic process

[Term]
id: GO:0045533
name: negative regulation of interleukin-25 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-25." [GOC:go_curators]
synonym: "down regulation of interleukin-25 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-25 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-25 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-25 biosynthetic process" NARROW []
synonym: "negative regulation of IL-25 biosynthesis" EXACT []
synonym: "negative regulation of IL-25 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-25 anabolism" EXACT []
synonym: "negative regulation of interleukin-25 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-25 formation" EXACT []
synonym: "negative regulation of interleukin-25 synthesis" EXACT []
is_a: GO:0032709 ! negative regulation of interleukin-25 production
is_a: GO:0045379 ! negative regulation of interleukin-17 biosynthetic process
is_a: GO:0045529 ! regulation of interleukin-25 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045525 ! interleukin-25 biosynthetic process
relationship: negatively_regulates GO:0045525 ! interleukin-25 biosynthetic process

[Term]
id: GO:0045534
name: negative regulation of interleukin-26 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-26." [GOC:go_curators]
synonym: "down regulation of interleukin-26 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-26 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-26 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-26 biosynthetic process" NARROW []
synonym: "negative regulation of IL-26 biosynthesis" EXACT []
synonym: "negative regulation of IL-26 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-26 anabolism" EXACT []
synonym: "negative regulation of interleukin-26 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-26 formation" EXACT []
synonym: "negative regulation of interleukin-26 synthesis" EXACT []
is_a: GO:0032710 ! negative regulation of interleukin-26 production
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045530 ! regulation of interleukin-26 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045526 ! interleukin-26 biosynthetic process
relationship: negatively_regulates GO:0045526 ! interleukin-26 biosynthetic process

[Term]
id: GO:0045535
name: negative regulation of interleukin-27 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-27." [GOC:go_curators]
synonym: "down regulation of interleukin-27 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-27 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-27 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-27 biosynthetic process" NARROW []
synonym: "negative regulation of IL-27 biosynthesis" EXACT []
synonym: "negative regulation of IL-27 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-27 anabolism" EXACT []
synonym: "negative regulation of interleukin-27 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-27 formation" EXACT []
synonym: "negative regulation of interleukin-27 synthesis" EXACT []
is_a: GO:0032711 ! negative regulation of interleukin-27 production
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045531 ! regulation of interleukin-27 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045527 ! interleukin-27 biosynthetic process
relationship: negatively_regulates GO:0045527 ! interleukin-27 biosynthetic process

[Term]
id: GO:0045536
name: positive regulation of interleukin-24 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-24." [GOC:go_curators]
synonym: "activation of interleukin-24 biosynthetic process" NARROW []
synonym: "positive regulation of IL-24 biosynthesis" EXACT []
synonym: "positive regulation of IL-24 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-24 anabolism" EXACT []
synonym: "positive regulation of interleukin-24 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-24 formation" EXACT []
synonym: "positive regulation of interleukin-24 synthesis" EXACT []
synonym: "stimulation of interleukin-24 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-24 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-24 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-24 biosynthetic process" EXACT []
is_a: GO:0032748 ! positive regulation of interleukin-24 production
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045528 ! regulation of interleukin-24 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045524 ! interleukin-24 biosynthetic process
relationship: positively_regulates GO:0045524 ! interleukin-24 biosynthetic process

[Term]
id: GO:0045537
name: positive regulation of interleukin-25 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-25." [GOC:go_curators]
synonym: "activation of interleukin-25 biosynthetic process" NARROW []
synonym: "positive regulation of IL-25 biosynthesis" EXACT []
synonym: "positive regulation of IL-25 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-25 anabolism" EXACT []
synonym: "positive regulation of interleukin-25 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-25 formation" EXACT []
synonym: "positive regulation of interleukin-25 synthesis" EXACT []
synonym: "stimulation of interleukin-25 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-25 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-25 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-25 biosynthetic process" EXACT []
is_a: GO:0032749 ! positive regulation of interleukin-25 production
is_a: GO:0045380 ! positive regulation of interleukin-17 biosynthetic process
is_a: GO:0045529 ! regulation of interleukin-25 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045525 ! interleukin-25 biosynthetic process
relationship: positively_regulates GO:0045525 ! interleukin-25 biosynthetic process

[Term]
id: GO:0045538
name: positive regulation of interleukin-26 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-26." [GOC:go_curators]
synonym: "activation of interleukin-26 biosynthetic process" NARROW []
synonym: "positive regulation of IL-26 biosynthesis" EXACT []
synonym: "positive regulation of IL-26 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-26 anabolism" EXACT []
synonym: "positive regulation of interleukin-26 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-26 formation" EXACT []
synonym: "positive regulation of interleukin-26 synthesis" EXACT []
synonym: "stimulation of interleukin-26 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-26 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-26 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-26 biosynthetic process" EXACT []
is_a: GO:0032750 ! positive regulation of interleukin-26 production
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045530 ! regulation of interleukin-26 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045526 ! interleukin-26 biosynthetic process
relationship: positively_regulates GO:0045526 ! interleukin-26 biosynthetic process

[Term]
id: GO:0045539
name: positive regulation of interleukin-27 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-27." [GOC:go_curators]
synonym: "activation of interleukin-27 biosynthetic process" NARROW []
synonym: "positive regulation of IL-27 biosynthesis" EXACT []
synonym: "positive regulation of IL-27 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-27 anabolism" EXACT []
synonym: "positive regulation of interleukin-27 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-27 formation" EXACT []
synonym: "positive regulation of interleukin-27 synthesis" EXACT []
synonym: "stimulation of interleukin-27 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-27 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-27 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-27 biosynthetic process" EXACT []
is_a: GO:0032751 ! positive regulation of interleukin-27 production
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045531 ! regulation of interleukin-27 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045527 ! interleukin-27 biosynthetic process
relationship: positively_regulates GO:0045527 ! interleukin-27 biosynthetic process

[Term]
id: GO:0045540
name: regulation of cholesterol biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol." [GOC:go_curators]
synonym: "regulation of cholesterol anabolism" EXACT []
synonym: "regulation of cholesterol biosynthesis" EXACT []
synonym: "regulation of cholesterol formation" EXACT []
synonym: "regulation of cholesterol synthesis" EXACT []
is_a: GO:0050810 ! regulation of steroid biosynthetic process
is_a: GO:0090181 ! regulation of cholesterol metabolic process
is_a: GO:1902930 ! regulation of alcohol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006695 ! cholesterol biosynthetic process
relationship: regulates GO:0006695 ! cholesterol biosynthetic process

[Term]
id: GO:0045541
name: negative regulation of cholesterol biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol." [GOC:go_curators]
synonym: "down regulation of cholesterol biosynthetic process" EXACT []
synonym: "down-regulation of cholesterol biosynthetic process" EXACT []
synonym: "downregulation of cholesterol biosynthetic process" EXACT []
synonym: "inhibition of cholesterol biosynthetic process" NARROW []
synonym: "negative regulation of cholesterol anabolism" EXACT []
synonym: "negative regulation of cholesterol biosynthesis" EXACT []
synonym: "negative regulation of cholesterol formation" EXACT []
synonym: "negative regulation of cholesterol synthesis" EXACT []
is_a: GO:0010894 ! negative regulation of steroid biosynthetic process
is_a: GO:0045540 ! regulation of cholesterol biosynthetic process
is_a: GO:0090206 ! negative regulation of cholesterol metabolic process
is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006695 ! cholesterol biosynthetic process
relationship: negatively_regulates GO:0006695 ! cholesterol biosynthetic process

[Term]
id: GO:0045542
name: positive regulation of cholesterol biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol." [GOC:go_curators]
synonym: "activation of cholesterol biosynthetic process" NARROW []
synonym: "positive regulation of cholesterol anabolism" EXACT []
synonym: "positive regulation of cholesterol biosynthesis" EXACT []
synonym: "positive regulation of cholesterol formation" EXACT []
synonym: "positive regulation of cholesterol synthesis" EXACT []
synonym: "stimulation of cholesterol biosynthetic process" NARROW []
synonym: "up regulation of cholesterol biosynthetic process" EXACT []
synonym: "up-regulation of cholesterol biosynthetic process" EXACT []
synonym: "upregulation of cholesterol biosynthetic process" EXACT []
is_a: GO:0010893 ! positive regulation of steroid biosynthetic process
is_a: GO:0045540 ! regulation of cholesterol biosynthetic process
is_a: GO:0090205 ! positive regulation of cholesterol metabolic process
is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006695 ! cholesterol biosynthetic process
relationship: positively_regulates GO:0006695 ! cholesterol biosynthetic process

[Term]
id: GO:0045543
name: gibberellin 2-beta-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a gibberellin + 2-oxoglutarate + O2 = a 2-beta-hydroxygibberellin + succinate + CO2." [EC:1.14.11.13, GOC:kad]
synonym: "(gibberellin-1),2-oxoglutarate:oxygen oxidoreductase (2beta-hydroxylating)" NARROW [EC:1.14.11.13]
synonym: "gibberellin 2-beta-hydroxylase activity" EXACT [EC:1.14.11.13]
synonym: "gibberellin 2-oxidase activity" EXACT []
synonym: "gibberellin 2beta-dioxygenase activity" EXACT [EC:1.14.11.13]
synonym: "gibberellin 2beta-hydroxylase activity" EXACT [EC:1.14.11.13]
xref: EC:1.14.11.13
xref: MetaCyc:PWY-102
xref: RHEA:15008
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0045544
name: gibberellin 20-oxidase activity
namespace: molecular_function
def: "Catalysis of the oxidation of C-20 gibberellins to form the corresponding C-19 lactones." [PMID:7604047]
subset: mf_needs_review
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0045545
name: syndecan binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with syndecan, an integral membrane proteoglycan (250-300 kDa) associated largely with epithelial cells." [GOC:go_curators, PMID:9355727]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0045547
name: dehydrodolichyl diphosphate synthase activity
namespace: molecular_function
def: "Catalysis of the condensation of isopentenyl diphosphate and farnesyl diphosphate in the cis-configuration to form dehydrodolichyl diphosphate." [PMID:9858571]
is_a: GO:0004659 ! prenyltransferase activity

[Term]
id: GO:0045548
name: phenylalanine ammonia-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-phenylalanine = NH(4)(+) + trans-cinnamate." [RHEA:21387]
synonym: "L-phenylalanine ammonia-lyase activity" EXACT [EC:4.3.1.24]
synonym: "PAL activity" BROAD [EC:4.3.1.24]
synonym: "phe ammonia-lyase activity" EXACT [EC:4.3.1.24]
synonym: "phenylalanine ammonium-lyase activity" EXACT [EC:4.3.1.24]
synonym: "phenylalanine deaminase activity" EXACT [EC:4.3.1.24]
xref: EC:4.3.1.24
xref: EC:4.3.1.25
xref: RHEA:21387 "L-phenylalanine = NH(4)(+) + trans-cinnamate"
is_a: GO:0016841 ! ammonia-lyase activity

[Term]
id: GO:0045549
name: 9-cis-epoxycarotenoid dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reactions: a 9-cis-epoxycarotenoid + O2 = 2-cis,4-trans-xanthoxin + a 12'-apo-carotenal; 9-cis-violaxanthin + O2 = 2-cis,4-trans-xanthoxin + (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al; and 9'-cis-neoxanthin + O2 = 2-cis,4-trans-xanthoxin + (3S,5R,6R)-5,6-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al." [EC:1.13.11.51]
synonym: "9-cis-epoxycarotenoid 11,12-dioxygenase activity" EXACT [EC:1.13.11.51]
synonym: "AtNCED3" RELATED [EC:1.13.11.51]
synonym: "NCED" RELATED [EC:1.13.11.51]
synonym: "neoxanthin cleavage enzyme" RELATED []
synonym: "nine-cis-epoxycarotenoid dioxygenase activity" EXACT [EC:1.13.11.51]
synonym: "PvNCED1" RELATED [EC:1.13.11.51]
synonym: "VP14" RELATED [EC:1.13.11.51]
xref: EC:1.13.11.51
is_a: GO:0010436 ! carotenoid dioxygenase activity

[Term]
id: GO:0045550
name: geranylgeranyl reductase activity
namespace: molecular_function
def: "Catalysis of the formation of phytyl group from the stepwise reduction of a geranylgeranyl group." [PMID:9492312]
subset: gosubset_prok
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0045551
name: cinnamyl-alcohol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cinnamyl alcohol + NADP+ = cinnamaldehyde + NADPH + H+." [EC:1.1.1.195]
synonym: "CAD activity" BROAD [EC:1.1.1.195]
synonym: "cinnamyl alcohol dehydrogenase activity" EXACT [EC:1.1.1.195]
synonym: "cinnamyl-alcohol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.195]
xref: EC:1.1.1.195
xref: MetaCyc:CINNAMYL-ALCOHOL-DEHYDROGENASE-RXN
xref: RHEA:10395
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0045552
name: dihydrokaempferol 4-reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-3,4-leucopelargonidin + NADP+ = (+)-dihydrokaempferol + NADPH + H+." [EC:1.1.1.219]
subset: gosubset_prok
synonym: "cis-3,4-leucopelargonidin:NADP+ 4-oxidoreductase activity" EXACT [EC:1.1.1.219]
synonym: "dihydroflavanol 4-reductase activity" EXACT [EC:1.1.1.219]
synonym: "dihydroflavonol 4-reductase activity" EXACT [EC:1.1.1.219]
synonym: "dihydromyricetin reductase activity" EXACT [EC:1.1.1.219]
synonym: "dihydroquercetin reductase activity" EXACT [EC:1.1.1.219]
synonym: "NADPH-dihydromyricetin reductase activity" EXACT [EC:1.1.1.219]
xref: EC:1.1.1.219
xref: MetaCyc:DIHYDROKAEMPFEROL-4-REDUCTASE-RXN
xref: RHEA:23019
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0045553
name: TRAIL biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand). TRAIL induces apoptosis in a wide variety of cells and is a member of the tumor necrosis factor (TNF) family of cytokines." [PMID:9311998]
synonym: "TRAIL anabolism" EXACT []
synonym: "TRAIL biosynthesis" EXACT []
synonym: "TRAIL formation" EXACT []
synonym: "TRAIL synthesis" EXACT []
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032639 ! TRAIL production

[Term]
id: GO:0045554
name: regulation of TRAIL biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL, TNF-related apoptosis inducing ligand." [GOC:go_curators]
synonym: "regulation of TRAIL anabolism" EXACT []
synonym: "regulation of TRAIL biosynthesis" EXACT []
synonym: "regulation of TRAIL formation" EXACT []
synonym: "regulation of TRAIL synthesis" EXACT []
is_a: GO:0032679 ! regulation of TRAIL production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045553 ! TRAIL biosynthetic process
relationship: regulates GO:0045553 ! TRAIL biosynthetic process

[Term]
id: GO:0045555
name: negative regulation of TRAIL biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL, TNF-related apoptosis inducing ligand." [GOC:go_curators]
synonym: "down regulation of TRAIL biosynthetic process" EXACT []
synonym: "down-regulation of TRAIL biosynthetic process" EXACT []
synonym: "downregulation of TRAIL biosynthetic process" EXACT []
synonym: "inhibition of TRAIL biosynthetic process" NARROW []
synonym: "negative regulation of TRAIL anabolism" EXACT []
synonym: "negative regulation of TRAIL biosynthesis" EXACT []
synonym: "negative regulation of TRAIL formation" EXACT []
synonym: "negative regulation of TRAIL synthesis" EXACT []
is_a: GO:0032719 ! negative regulation of TRAIL production
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045554 ! regulation of TRAIL biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045553 ! TRAIL biosynthetic process
relationship: negatively_regulates GO:0045553 ! TRAIL biosynthetic process

[Term]
id: GO:0045556
name: positive regulation of TRAIL biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL, TNF-related apoptosis inducing ligand." [GOC:go_curators]
synonym: "activation of TRAIL biosynthetic process" NARROW []
synonym: "positive regulation of TRAIL anabolism" EXACT []
synonym: "positive regulation of TRAIL biosynthesis" EXACT []
synonym: "positive regulation of TRAIL formation" EXACT []
synonym: "positive regulation of TRAIL synthesis" EXACT []
synonym: "stimulation of TRAIL biosynthetic process" NARROW []
synonym: "up regulation of TRAIL biosynthetic process" EXACT []
synonym: "up-regulation of TRAIL biosynthetic process" EXACT []
synonym: "upregulation of TRAIL biosynthetic process" EXACT []
is_a: GO:0032759 ! positive regulation of TRAIL production
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045554 ! regulation of TRAIL biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045553 ! TRAIL biosynthetic process
relationship: positively_regulates GO:0045553 ! TRAIL biosynthetic process

[Term]
id: GO:0045557
name: TRAIL receptor biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the TRAIL (TNF-related apoptosis inducing ligand) receptor." [GOC:go_curators]
synonym: "TRAIL receptor anabolism" EXACT []
synonym: "TRAIL receptor biosynthesis" EXACT []
synonym: "TRAIL receptor formation" EXACT []
synonym: "TRAIL receptor synthesis" EXACT []
is_a: GO:0032800 ! receptor biosynthetic process

[Term]
id: GO:0045558
name: TRAIL receptor 1 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of TRAIL-R1 (TNF-related apoptosis inducing ligand receptor 1), which engages a caspase-dependent apoptotic pathway." [GOC:go_curators, PMID:9311998]
synonym: "TRAIL receptor 1 anabolism" EXACT []
synonym: "TRAIL receptor 1 biosynthesis" EXACT []
synonym: "TRAIL receptor 1 formation" EXACT []
synonym: "TRAIL receptor 1 synthesis" EXACT []
synonym: "tumor necrosis factor receptor superfamily member 10A biosynthetic process" EXACT [PR:000002108]
is_a: GO:0019538 ! protein metabolic process
is_a: GO:0045557 ! TRAIL receptor biosynthetic process

[Term]
id: GO:0045559
name: TRAIL receptor 2 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of TRAIL-R2 (TNF-related apoptosis inducing ligand receptor 2), which engages a caspase-dependent apoptotic pathway and mediates apoptosis via the intracellular adaptor molecule FADD/MORT1." [GOC:go_curators, PMID:9311998]
synonym: "TRAIL receptor 2 anabolism" EXACT []
synonym: "TRAIL receptor 2 biosynthesis" EXACT []
synonym: "TRAIL receptor 2 formation" EXACT []
synonym: "TRAIL receptor 2 synthesis" EXACT []
synonym: "tumor necrosis factor receptor superfamily member 10B biosynthetic process" EXACT [PR:000002109]
is_a: GO:0019538 ! protein metabolic process
is_a: GO:0045557 ! TRAIL receptor biosynthetic process

[Term]
id: GO:0045560
name: regulation of TRAIL receptor biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the TRAIL (TNF-related apoptosis inducing ligand) receptor." [GOC:go_curators]
synonym: "regulation of TRAIL receptor anabolism" EXACT []
synonym: "regulation of TRAIL receptor biosynthesis" EXACT []
synonym: "regulation of TRAIL receptor formation" EXACT []
synonym: "regulation of TRAIL receptor synthesis" EXACT []
is_a: GO:0010869 ! regulation of receptor biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045557 ! TRAIL receptor biosynthetic process
relationship: regulates GO:0045557 ! TRAIL receptor biosynthetic process

[Term]
id: GO:0045561
name: regulation of TRAIL receptor 1 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 1." [GOC:go_curators]
synonym: "regulation of TRAIL receptor 1 anabolism" EXACT []
synonym: "regulation of TRAIL receptor 1 biosynthesis" EXACT []
synonym: "regulation of TRAIL receptor 1 formation" EXACT []
synonym: "regulation of TRAIL receptor 1 synthesis" EXACT []
is_a: GO:0045560 ! regulation of TRAIL receptor biosynthetic process
is_a: GO:0051246 ! regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045558 ! TRAIL receptor 1 biosynthetic process
relationship: regulates GO:0045558 ! TRAIL receptor 1 biosynthetic process

[Term]
id: GO:0045562
name: regulation of TRAIL receptor 2 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 2." [GOC:go_curators]
synonym: "regulation of TRAIL receptor 2 anabolism" EXACT []
synonym: "regulation of TRAIL receptor 2 biosynthesis" EXACT []
synonym: "regulation of TRAIL receptor 2 formation" EXACT []
synonym: "regulation of TRAIL receptor 2 synthesis" EXACT []
is_a: GO:0045560 ! regulation of TRAIL receptor biosynthetic process
is_a: GO:0051246 ! regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045559 ! TRAIL receptor 2 biosynthetic process
relationship: regulates GO:0045559 ! TRAIL receptor 2 biosynthetic process

[Term]
id: GO:0045563
name: negative regulation of TRAIL receptor biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the TRAIL (TNF-related apoptosis inducing ligand) receptor." [GOC:go_curators]
synonym: "down regulation of TRAIL receptor biosynthetic process" EXACT []
synonym: "down-regulation of TRAIL receptor biosynthetic process" EXACT []
synonym: "downregulation of TRAIL receptor biosynthetic process" EXACT []
synonym: "inhibition of TRAIL receptor biosynthetic process" NARROW []
synonym: "negative regulation of TRAIL receptor anabolism" EXACT []
synonym: "negative regulation of TRAIL receptor biosynthesis" EXACT []
synonym: "negative regulation of TRAIL receptor formation" EXACT []
synonym: "negative regulation of TRAIL receptor synthesis" EXACT []
is_a: GO:0010871 ! negative regulation of receptor biosynthetic process
is_a: GO:0045560 ! regulation of TRAIL receptor biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045557 ! TRAIL receptor biosynthetic process
relationship: negatively_regulates GO:0045557 ! TRAIL receptor biosynthetic process

[Term]
id: GO:0045564
name: positive regulation of TRAIL receptor biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the TRAIL (TNF-related apoptosis inducing ligand) receptor." [GOC:go_curators]
synonym: "activation of TRAIL receptor biosynthetic process" NARROW []
synonym: "positive regulation of TRAIL receptor anabolism" EXACT []
synonym: "positive regulation of TRAIL receptor biosynthesis" EXACT []
synonym: "positive regulation of TRAIL receptor formation" EXACT []
synonym: "positive regulation of TRAIL receptor synthesis" EXACT []
synonym: "stimulation of TRAIL receptor biosynthetic process" NARROW []
synonym: "up regulation of TRAIL receptor biosynthetic process" EXACT []
synonym: "up-regulation of TRAIL receptor biosynthetic process" EXACT []
synonym: "upregulation of TRAIL receptor biosynthetic process" EXACT []
is_a: GO:0010870 ! positive regulation of receptor biosynthetic process
is_a: GO:0045560 ! regulation of TRAIL receptor biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045557 ! TRAIL receptor biosynthetic process
relationship: positively_regulates GO:0045557 ! TRAIL receptor biosynthetic process

[Term]
id: GO:0045565
name: negative regulation of TRAIL receptor 1 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 1." [GOC:go_curators]
synonym: "down regulation of TRAIL receptor 1 biosynthetic process" EXACT []
synonym: "down-regulation of TRAIL receptor 1 biosynthetic process" EXACT []
synonym: "downregulation of TRAIL receptor 1 biosynthetic process" EXACT []
synonym: "inhibition of TRAIL receptor 1 biosynthetic process" NARROW []
synonym: "negative regulation of TRAIL receptor 1 anabolism" EXACT []
synonym: "negative regulation of TRAIL receptor 1 biosynthesis" EXACT []
synonym: "negative regulation of TRAIL receptor 1 formation" EXACT []
synonym: "negative regulation of TRAIL receptor 1 synthesis" EXACT []
is_a: GO:0045561 ! regulation of TRAIL receptor 1 biosynthetic process
is_a: GO:0045563 ! negative regulation of TRAIL receptor biosynthetic process
is_a: GO:0051248 ! negative regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045558 ! TRAIL receptor 1 biosynthetic process
relationship: negatively_regulates GO:0045558 ! TRAIL receptor 1 biosynthetic process

[Term]
id: GO:0045566
name: positive regulation of TRAIL receptor 1 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 1." [GOC:go_curators]
synonym: "activation of TRAIL receptor 1 biosynthetic process" NARROW []
synonym: "positive regulation of TRAIL receptor 1 anabolism" EXACT []
synonym: "positive regulation of TRAIL receptor 1 biosynthesis" EXACT []
synonym: "positive regulation of TRAIL receptor 1 formation" EXACT []
synonym: "positive regulation of TRAIL receptor 1 synthesis" EXACT []
synonym: "stimulation of TRAIL receptor 1 biosynthetic process" NARROW []
synonym: "up regulation of TRAIL receptor 1 biosynthetic process" EXACT []
synonym: "up-regulation of TRAIL receptor 1 biosynthetic process" EXACT []
synonym: "upregulation of TRAIL receptor 1 biosynthetic process" EXACT []
is_a: GO:0045561 ! regulation of TRAIL receptor 1 biosynthetic process
is_a: GO:0045564 ! positive regulation of TRAIL receptor biosynthetic process
is_a: GO:0051247 ! positive regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045558 ! TRAIL receptor 1 biosynthetic process
relationship: positively_regulates GO:0045558 ! TRAIL receptor 1 biosynthetic process

[Term]
id: GO:0045567
name: negative regulation of TRAIL receptor 2 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 2." [GOC:go_curators]
synonym: "down regulation of TRAIL receptor 2 biosynthetic process" EXACT []
synonym: "down-regulation of TRAIL receptor 2 biosynthetic process" EXACT []
synonym: "downregulation of TRAIL receptor 2 biosynthetic process" EXACT []
synonym: "inhibition of TRAIL receptor 2 biosynthetic process" NARROW []
synonym: "negative regulation of TRAIL receptor 2 anabolism" EXACT []
synonym: "negative regulation of TRAIL receptor 2 biosynthesis" EXACT []
synonym: "negative regulation of TRAIL receptor 2 formation" EXACT []
synonym: "negative regulation of TRAIL receptor 2 synthesis" EXACT []
is_a: GO:0045562 ! regulation of TRAIL receptor 2 biosynthetic process
is_a: GO:0045563 ! negative regulation of TRAIL receptor biosynthetic process
is_a: GO:0051248 ! negative regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045559 ! TRAIL receptor 2 biosynthetic process
relationship: negatively_regulates GO:0045559 ! TRAIL receptor 2 biosynthetic process

[Term]
id: GO:0045568
name: positive regulation of TRAIL receptor 2 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 2." [GOC:go_curators]
synonym: "activation of TRAIL receptor 2 biosynthetic process" NARROW []
synonym: "positive regulation of TRAIL receptor 2 anabolism" EXACT []
synonym: "positive regulation of TRAIL receptor 2 biosynthesis" EXACT []
synonym: "positive regulation of TRAIL receptor 2 formation" EXACT []
synonym: "positive regulation of TRAIL receptor 2 synthesis" EXACT []
synonym: "stimulation of TRAIL receptor 2 biosynthetic process" NARROW []
synonym: "up regulation of TRAIL receptor 2 biosynthetic process" EXACT []
synonym: "up-regulation of TRAIL receptor 2 biosynthetic process" EXACT []
synonym: "upregulation of TRAIL receptor 2 biosynthetic process" EXACT []
is_a: GO:0045562 ! regulation of TRAIL receptor 2 biosynthetic process
is_a: GO:0045564 ! positive regulation of TRAIL receptor biosynthetic process
is_a: GO:0051247 ! positive regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045559 ! TRAIL receptor 2 biosynthetic process
relationship: positively_regulates GO:0045559 ! TRAIL receptor 2 biosynthetic process

[Term]
id: GO:0045569
name: TRAIL binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with TRAIL (TNF-related apoptosis inducing ligand), a member of the tumor necrosis factor ligand family that rapidly induces apoptosis in a variety of transformed cell lines." [GOC:go_curators, PMID:9082980]
subset: goslim_chembl
synonym: "Apo-2L binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0045570
name: regulation of imaginal disc growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the growth of the imaginal disc." [GOC:go_curators]
is_a: GO:0046620 ! regulation of organ growth
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007446 ! imaginal disc growth
relationship: regulates GO:0007446 ! imaginal disc growth

[Term]
id: GO:0045571
name: negative regulation of imaginal disc growth
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of imaginal disc growth." [GOC:go_curators]
synonym: "down regulation of imaginal disc growth" EXACT []
synonym: "down-regulation of imaginal disc growth" EXACT []
synonym: "downregulation of imaginal disc growth" EXACT []
synonym: "inhibition of imaginal disc growth" NARROW []
is_a: GO:0045570 ! regulation of imaginal disc growth
is_a: GO:0046621 ! negative regulation of organ growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007446 ! imaginal disc growth
relationship: negatively_regulates GO:0007446 ! imaginal disc growth

[Term]
id: GO:0045572
name: positive regulation of imaginal disc growth
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of imaginal disc growth." [GOC:go_curators]
synonym: "activation of imaginal disc growth" NARROW []
synonym: "stimulation of imaginal disc growth" NARROW []
synonym: "up regulation of imaginal disc growth" EXACT []
synonym: "up-regulation of imaginal disc growth" EXACT []
synonym: "upregulation of imaginal disc growth" EXACT []
is_a: GO:0045570 ! regulation of imaginal disc growth
is_a: GO:0046622 ! positive regulation of organ growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007446 ! imaginal disc growth
relationship: positively_regulates GO:0007446 ! imaginal disc growth

[Term]
id: GO:0045574
name: sterigmatocystin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds." [CHEBI:18227, GOC:go_curators]
subset: gosubset_prok
synonym: "sterigmatocystin breakdown" EXACT []
synonym: "sterigmatocystin catabolism" EXACT []
synonym: "sterigmatocystin degradation" EXACT []
is_a: GO:0009407 ! toxin catabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0045460 ! sterigmatocystin metabolic process
is_a: GO:1901377 ! organic heteropentacyclic compound catabolic process

[Term]
id: GO:0045575
name: basophil activation
namespace: biological_process
def: "The change in morphology and behavior of a basophil resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the basophil has specifically bound via IgE bound to Fc-epsilonRI receptors." [GOC:mgi_curators, ISBN:0781735149]
xref: Wikipedia:Basophil_activation
is_a: GO:0036230 ! granulocyte activation

[Term]
id: GO:0045576
name: mast cell activation
namespace: biological_process
def: "The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors." [GOC:mgi_curators, ISBN:0781735149]
is_a: GO:0002274 ! myeloid leukocyte activation

[Term]
id: GO:0045577
name: regulation of B cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of B cell differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "regulation of B cell development" RELATED [GOC:add]
synonym: "regulation of B lymphocyte differentiation" EXACT []
synonym: "regulation of B-cell differentiation" EXACT []
synonym: "regulation of B-lymphocyte differentiation" EXACT []
is_a: GO:0045619 ! regulation of lymphocyte differentiation
is_a: GO:0050864 ! regulation of B cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030183 ! B cell differentiation
relationship: regulates GO:0030183 ! B cell differentiation

[Term]
id: GO:0045578
name: negative regulation of B cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of B cell differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "down regulation of B cell differentiation" EXACT []
synonym: "down-regulation of B cell differentiation" EXACT []
synonym: "downregulation of B cell differentiation" EXACT []
synonym: "inhibition of B cell differentiation" NARROW []
synonym: "negative regulation of B cell development" RELATED [GOC:add]
synonym: "negative regulation of B lymphocyte differentiation" EXACT []
synonym: "negative regulation of B-cell differentiation" EXACT []
synonym: "negative regulation of B-lymphocyte differentiation" EXACT []
is_a: GO:0045577 ! regulation of B cell differentiation
is_a: GO:0045620 ! negative regulation of lymphocyte differentiation
is_a: GO:0050869 ! negative regulation of B cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030183 ! B cell differentiation
relationship: negatively_regulates GO:0030183 ! B cell differentiation

[Term]
id: GO:0045579
name: positive regulation of B cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of B cell differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "activation of B cell differentiation" NARROW []
synonym: "positive regulation of B cell development" RELATED [GOC:add]
synonym: "positive regulation of B lymphocyte differentiation" EXACT []
synonym: "positive regulation of B-cell differentiation" EXACT []
synonym: "positive regulation of B-lymphocyte differentiation" EXACT []
synonym: "stimulation of B cell differentiation" NARROW []
synonym: "up regulation of B cell differentiation" EXACT []
synonym: "up-regulation of B cell differentiation" EXACT []
synonym: "upregulation of B cell differentiation" EXACT []
is_a: GO:0045577 ! regulation of B cell differentiation
is_a: GO:0045621 ! positive regulation of lymphocyte differentiation
is_a: GO:0050871 ! positive regulation of B cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030183 ! B cell differentiation
relationship: positively_regulates GO:0030183 ! B cell differentiation

[Term]
id: GO:0045580
name: regulation of T cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of T cell differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "regulation of T cell development" RELATED [GOC:add]
synonym: "regulation of T lymphocyte differentiation" EXACT []
synonym: "regulation of T-cell differentiation" EXACT []
synonym: "regulation of T-lymphocyte differentiation" EXACT []
is_a: GO:0045619 ! regulation of lymphocyte differentiation
is_a: GO:0050863 ! regulation of T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030217 ! T cell differentiation
relationship: regulates GO:0030217 ! T cell differentiation

[Term]
id: GO:0045581
name: negative regulation of T cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "down regulation of T cell differentiation" EXACT []
synonym: "down-regulation of T cell differentiation" EXACT []
synonym: "downregulation of T cell differentiation" EXACT []
synonym: "inhibition of T cell differentiation" NARROW []
synonym: "negative regulation of T cell development" RELATED [GOC:add]
synonym: "negative regulation of T lymphocyte differentiation" EXACT []
synonym: "negative regulation of T-cell differentiation" EXACT []
synonym: "negative regulation of T-lymphocyte differentiation" EXACT []
is_a: GO:0045580 ! regulation of T cell differentiation
is_a: GO:0045620 ! negative regulation of lymphocyte differentiation
is_a: GO:0050868 ! negative regulation of T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030217 ! T cell differentiation
relationship: negatively_regulates GO:0030217 ! T cell differentiation

[Term]
id: GO:0045582
name: positive regulation of T cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T cell differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "activation of T cell differentiation" NARROW []
synonym: "positive regulation of T cell development" RELATED [GOC:add]
synonym: "positive regulation of T lymphocyte differentiation" EXACT []
synonym: "positive regulation of T-cell differentiation" EXACT []
synonym: "positive regulation of T-lymphocyte differentiation" EXACT []
synonym: "stimulation of T cell differentiation" NARROW []
synonym: "up regulation of T cell differentiation" EXACT []
synonym: "up-regulation of T cell differentiation" EXACT []
synonym: "upregulation of T cell differentiation" EXACT []
is_a: GO:0045580 ! regulation of T cell differentiation
is_a: GO:0045621 ! positive regulation of lymphocyte differentiation
is_a: GO:0050870 ! positive regulation of T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030217 ! T cell differentiation
relationship: positively_regulates GO:0030217 ! T cell differentiation

[Term]
id: GO:0045583
name: regulation of cytotoxic T cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cytotoxic T cell differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "regulation of cytotoxic T cell development" RELATED [GOC:add]
synonym: "regulation of cytotoxic T lymphocyte differentiation" EXACT []
synonym: "regulation of cytotoxic T-cell differentiation" EXACT []
synonym: "regulation of cytotoxic T-lymphocyte differentiation" EXACT []
is_a: GO:0045580 ! regulation of T cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045065 ! cytotoxic T cell differentiation
relationship: regulates GO:0045065 ! cytotoxic T cell differentiation

[Term]
id: GO:0045584
name: negative regulation of cytotoxic T cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cytotoxic T cell differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "down regulation of cytotoxic T cell differentiation" EXACT []
synonym: "down-regulation of cytotoxic T cell differentiation" EXACT []
synonym: "downregulation of cytotoxic T cell differentiation" EXACT []
synonym: "inhibition of cytotoxic T cell differentiation" NARROW []
synonym: "negative regulation of cytotoxic T cell development" RELATED [GOC:add]
synonym: "negative regulation of cytotoxic T lymphocyte differentiation" EXACT []
synonym: "negative regulation of cytotoxic T-cell differentiation" EXACT []
synonym: "negative regulation of cytotoxic T-lymphocyte differentiation" EXACT []
is_a: GO:0045581 ! negative regulation of T cell differentiation
is_a: GO:0045583 ! regulation of cytotoxic T cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045065 ! cytotoxic T cell differentiation
relationship: negatively_regulates GO:0045065 ! cytotoxic T cell differentiation

[Term]
id: GO:0045585
name: positive regulation of cytotoxic T cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cytotoxic T cell differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "activation of cytotoxic T cell differentiation" NARROW []
synonym: "positive regulation of cytotoxic T cell development" RELATED [GOC:add]
synonym: "positive regulation of cytotoxic T lymphocyte differentiation" EXACT []
synonym: "positive regulation of cytotoxic T-cell differentiation" EXACT []
synonym: "positive regulation of cytotoxic T-lymphocyte differentiation" EXACT []
synonym: "stimulation of cytotoxic T cell differentiation" NARROW []
synonym: "up regulation of cytotoxic T cell differentiation" EXACT []
synonym: "up-regulation of cytotoxic T cell differentiation" EXACT []
synonym: "upregulation of cytotoxic T cell differentiation" EXACT []
is_a: GO:0045582 ! positive regulation of T cell differentiation
is_a: GO:0045583 ! regulation of cytotoxic T cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045065 ! cytotoxic T cell differentiation
relationship: positively_regulates GO:0045065 ! cytotoxic T cell differentiation

[Term]
id: GO:0045586
name: regulation of gamma-delta T cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gamma-delta T cell differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "regulation of gamma-delta T cell development" RELATED [GOC:add]
synonym: "regulation of gamma-delta T lymphocyte differentiation" EXACT []
synonym: "regulation of gamma-delta T-cell differentiation" EXACT []
synonym: "regulation of gamma-delta T-lymphocyte differentiation" EXACT []
is_a: GO:0045580 ! regulation of T cell differentiation
is_a: GO:0046643 ! regulation of gamma-delta T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042492 ! gamma-delta T cell differentiation
relationship: regulates GO:0042492 ! gamma-delta T cell differentiation

[Term]
id: GO:0045587
name: negative regulation of gamma-delta T cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of gamma-delta T cell differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "down regulation of gamma-delta T cell differentiation" EXACT []
synonym: "down-regulation of gamma-delta T cell differentiation" EXACT []
synonym: "downregulation of gamma-delta T cell differentiation" EXACT []
synonym: "inhibition of gamma-delta T cell differentiation" NARROW []
synonym: "negative regulation of gamma-delta T cell development" RELATED [GOC:add]
synonym: "negative regulation of gamma-delta T lymphocyte differentiation" EXACT []
synonym: "negative regulation of gamma-delta T-cell differentiation" EXACT []
synonym: "negative regulation of gamma-delta T-lymphocyte differentiation" EXACT []
is_a: GO:0045581 ! negative regulation of T cell differentiation
is_a: GO:0045586 ! regulation of gamma-delta T cell differentiation
is_a: GO:0046644 ! negative regulation of gamma-delta T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042492 ! gamma-delta T cell differentiation
relationship: negatively_regulates GO:0042492 ! gamma-delta T cell differentiation

[Term]
id: GO:0045588
name: positive regulation of gamma-delta T cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of gamma-delta T cell differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "activation of gamma-delta T cell differentiation" NARROW []
synonym: "positive regulation of gamma-delta T cell development" RELATED [GOC:add]
synonym: "positive regulation of gamma-delta T lymphocyte differentiation" EXACT []
synonym: "positive regulation of gamma-delta T-cell differentiation" EXACT []
synonym: "positive regulation of gamma-delta T-lymphocyte differentiation" EXACT []
synonym: "stimulation of gamma-delta T cell differentiation" NARROW []
synonym: "up regulation of gamma-delta T cell differentiation" EXACT []
synonym: "up-regulation of gamma-delta T cell differentiation" EXACT []
synonym: "upregulation of gamma-delta T cell differentiation" EXACT []
is_a: GO:0045582 ! positive regulation of T cell differentiation
is_a: GO:0045586 ! regulation of gamma-delta T cell differentiation
is_a: GO:0046645 ! positive regulation of gamma-delta T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042492 ! gamma-delta T cell differentiation
relationship: positively_regulates GO:0042492 ! gamma-delta T cell differentiation

[Term]
id: GO:0045589
name: regulation of regulatory T cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of differentiation of regulatory T cells." [ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "regulation of regulatory T cell development" RELATED [GOC:add]
synonym: "regulation of regulatory T lymphocyte differentiation" EXACT []
synonym: "regulation of regulatory T-cell differentiation" EXACT []
synonym: "regulation of regulatory T-lymphocyte differentiation" EXACT []
synonym: "regulation of suppressor T cell differentiation" EXACT []
synonym: "regulation of suppressor T lymphocyte differentiation" EXACT []
synonym: "regulation of suppressor T-cell differentiation" EXACT []
synonym: "regulation of suppressor T-lymphocyte differentiation" EXACT []
is_a: GO:0045580 ! regulation of T cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045066 ! regulatory T cell differentiation
relationship: regulates GO:0045066 ! regulatory T cell differentiation

[Term]
id: GO:0045590
name: negative regulation of regulatory T cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of differentiation of regulatory T cells." [ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "down regulation of regulatory T cell differentiation" EXACT []
synonym: "down-regulation of regulatory T cell differentiation" EXACT []
synonym: "downregulation of regulatory T cell differentiation" EXACT []
synonym: "inhibition of regulatory T cell differentiation" NARROW []
synonym: "negative regulation of regulatory T cell development" RELATED [GOC:add]
synonym: "negative regulation of regulatory T lymphocyte differentiation" EXACT []
synonym: "negative regulation of regulatory T-cell differentiation" EXACT []
synonym: "negative regulation of regulatory T-lymphocyte differentiation" EXACT []
synonym: "negative regulation of suppressor T cell differentiation" EXACT []
synonym: "negative regulation of suppressor T-cell differentiation" EXACT []
is_a: GO:0045581 ! negative regulation of T cell differentiation
is_a: GO:0045589 ! regulation of regulatory T cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045066 ! regulatory T cell differentiation
relationship: negatively_regulates GO:0045066 ! regulatory T cell differentiation

[Term]
id: GO:0045591
name: positive regulation of regulatory T cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of differentiation of regulatory T cells." [ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "activation of regulatory T cell differentiation" NARROW []
synonym: "positive regulation of regulatory T cell development" RELATED [GOC:add]
synonym: "positive regulation of regulatory T lymphocyte differentiation" EXACT []
synonym: "positive regulation of regulatory T-cell differentiation" EXACT []
synonym: "positive regulation of regulatory T-lymphocyte differentiation" EXACT []
synonym: "positive regulation of suppressor T cell differentiation" EXACT []
synonym: "positive regulation of suppressor T-cell differentiation" EXACT []
synonym: "stimulation of regulatory T cell differentiation" NARROW []
synonym: "up regulation of regulatory T cell differentiation" EXACT []
synonym: "up-regulation of regulatory T cell differentiation" EXACT []
synonym: "upregulation of regulatory T cell differentiation" EXACT []
is_a: GO:0045582 ! positive regulation of T cell differentiation
is_a: GO:0045589 ! regulation of regulatory T cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045066 ! regulatory T cell differentiation
relationship: positively_regulates GO:0045066 ! regulatory T cell differentiation

[Term]
id: GO:0045592
name: regulation of cumulus cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ovarian cumulus cell differentiation." [GOC:go_curators]
synonym: "regulation of ovarian cumulus cell differentiation" EXACT []
is_a: GO:0030856 ! regulation of epithelial cell differentiation
is_a: GO:0043900 ! regulation of multi-organism process
is_a: GO:0060284 ! regulation of cell development
is_a: GO:2000387 ! regulation of antral ovarian follicle growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001549 ! cumulus cell differentiation
relationship: regulates GO:0001549 ! cumulus cell differentiation

[Term]
id: GO:0045593
name: negative regulation of cumulus cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ovarian cumulus cell differentiation." [GOC:go_curators]
synonym: "down regulation of cumulus cell differentiation" EXACT []
synonym: "down-regulation of cumulus cell differentiation" EXACT []
synonym: "downregulation of cumulus cell differentiation" EXACT []
synonym: "inhibition of cumulus cell differentiation" NARROW []
synonym: "negative regulation of ovarian cumulus cell differentiation" EXACT []
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0030857 ! negative regulation of epithelial cell differentiation
is_a: GO:0043901 ! negative regulation of multi-organism process
is_a: GO:0045592 ! regulation of cumulus cell differentiation
is_a: GO:0048640 ! negative regulation of developmental growth
is_a: GO:2000355 ! negative regulation of ovarian follicle development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001549 ! cumulus cell differentiation
relationship: negatively_regulates GO:0001549 ! cumulus cell differentiation

[Term]
id: GO:0045594
name: positive regulation of cumulus cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ovarian cumulus cell differentiation." [GOC:go_curators]
synonym: "activation of cumulus cell differentiation" NARROW []
synonym: "positive regulation of ovarian cumulus cell differentiation" EXACT []
synonym: "stimulation of cumulus cell differentiation" NARROW []
synonym: "up regulation of cumulus cell differentiation" EXACT []
synonym: "up-regulation of cumulus cell differentiation" EXACT []
synonym: "upregulation of cumulus cell differentiation" EXACT []
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0030858 ! positive regulation of epithelial cell differentiation
is_a: GO:0043902 ! positive regulation of multi-organism process
is_a: GO:0045592 ! regulation of cumulus cell differentiation
is_a: GO:2000388 ! positive regulation of antral ovarian follicle growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001549 ! cumulus cell differentiation
relationship: positively_regulates GO:0001549 ! cumulus cell differentiation

[Term]
id: GO:0045595
name: regulation of cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030154 ! cell differentiation
relationship: regulates GO:0030154 ! cell differentiation

[Term]
id: GO:0045596
name: negative regulation of cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of cell differentiation" EXACT []
synonym: "down-regulation of cell differentiation" EXACT []
synonym: "downregulation of cell differentiation" EXACT []
synonym: "inhibition of cell differentiation" NARROW []
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051093 ! negative regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030154 ! cell differentiation
relationship: negatively_regulates GO:0030154 ! cell differentiation

[Term]
id: GO:0045597
name: positive regulation of cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell differentiation." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of cell differentiation" NARROW []
synonym: "stimulation of cell differentiation" NARROW []
synonym: "up regulation of cell differentiation" EXACT []
synonym: "up-regulation of cell differentiation" EXACT []
synonym: "upregulation of cell differentiation" EXACT []
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051094 ! positive regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030154 ! cell differentiation
relationship: positively_regulates GO:0030154 ! cell differentiation

[Term]
id: GO:0045598
name: regulation of fat cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of adipocyte differentiation." [GOC:go_curators]
synonym: "regulation of adipocyte cell differentiation" EXACT []
synonym: "regulation of adipocyte differentiation" EXACT []
is_a: GO:0045595 ! regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045444 ! fat cell differentiation
relationship: regulates GO:0045444 ! fat cell differentiation

[Term]
id: GO:0045599
name: negative regulation of fat cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation." [GOC:go_curators]
synonym: "down regulation of fat cell differentiation" EXACT []
synonym: "down-regulation of fat cell differentiation" EXACT []
synonym: "downregulation of fat cell differentiation" EXACT []
synonym: "inhibition of fat cell differentiation" NARROW []
synonym: "negative regulation of adipocyte cell differentiation" EXACT []
synonym: "negative regulation of adipocyte differentiation" EXACT []
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0045598 ! regulation of fat cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045444 ! fat cell differentiation
relationship: negatively_regulates GO:0045444 ! fat cell differentiation

[Term]
id: GO:0045600
name: positive regulation of fat cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of adipocyte differentiation." [GOC:go_curators]
synonym: "activation of fat cell differentiation" NARROW []
synonym: "positive regulation of adipocyte cell differentiation" EXACT []
synonym: "positive regulation of adipocyte differentiation" EXACT []
synonym: "stimulation of fat cell differentiation" NARROW []
synonym: "up regulation of fat cell differentiation" EXACT []
synonym: "up-regulation of fat cell differentiation" EXACT []
synonym: "upregulation of fat cell differentiation" EXACT []
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0045598 ! regulation of fat cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045444 ! fat cell differentiation
relationship: positively_regulates GO:0045444 ! fat cell differentiation

[Term]
id: GO:0045601
name: regulation of endothelial cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endothelial cell differentiation." [GOC:go_curators]
is_a: GO:0030856 ! regulation of epithelial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045446 ! endothelial cell differentiation
relationship: regulates GO:0045446 ! endothelial cell differentiation

[Term]
id: GO:0045602
name: negative regulation of endothelial cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of endothelial cell differentiation." [GOC:go_curators]
synonym: "down regulation of endothelial cell differentiation" EXACT []
synonym: "down-regulation of endothelial cell differentiation" EXACT []
synonym: "downregulation of endothelial cell differentiation" EXACT []
synonym: "inhibition of endothelial cell differentiation" NARROW []
is_a: GO:0030857 ! negative regulation of epithelial cell differentiation
is_a: GO:0045601 ! regulation of endothelial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045446 ! endothelial cell differentiation
relationship: negatively_regulates GO:0045446 ! endothelial cell differentiation

[Term]
id: GO:0045603
name: positive regulation of endothelial cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endothelial cell differentiation." [GOC:go_curators]
synonym: "activation of endothelial cell differentiation" NARROW []
synonym: "stimulation of endothelial cell differentiation" NARROW []
synonym: "up regulation of endothelial cell differentiation" EXACT []
synonym: "up-regulation of endothelial cell differentiation" EXACT []
synonym: "upregulation of endothelial cell differentiation" EXACT []
is_a: GO:0030858 ! positive regulation of epithelial cell differentiation
is_a: GO:0045601 ! regulation of endothelial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045446 ! endothelial cell differentiation
relationship: positively_regulates GO:0045446 ! endothelial cell differentiation

[Term]
id: GO:0045604
name: regulation of epidermal cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of epidermal cell differentiation." [GOC:go_curators]
synonym: "regulation of hypodermal cell differentiation" RELATED [GOC:kmv, GOC:rk]
is_a: GO:0030856 ! regulation of epithelial cell differentiation
is_a: GO:0045682 ! regulation of epidermis development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009913 ! epidermal cell differentiation
relationship: regulates GO:0009913 ! epidermal cell differentiation

[Term]
id: GO:0045605
name: negative regulation of epidermal cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal cell differentiation." [GOC:go_curators]
synonym: "down regulation of epidermal cell differentiation" EXACT []
synonym: "down-regulation of epidermal cell differentiation" EXACT []
synonym: "downregulation of epidermal cell differentiation" EXACT []
synonym: "inhibition of epidermal cell differentiation" NARROW []
synonym: "negative regulation of hypodermal cell differentiation" RELATED [GOC:kmv, GOC:rk]
is_a: GO:0030857 ! negative regulation of epithelial cell differentiation
is_a: GO:0045604 ! regulation of epidermal cell differentiation
is_a: GO:0045683 ! negative regulation of epidermis development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009913 ! epidermal cell differentiation
relationship: negatively_regulates GO:0009913 ! epidermal cell differentiation

[Term]
id: GO:0045606
name: positive regulation of epidermal cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of epidermal cell differentiation." [GOC:go_curators]
synonym: "activation of epidermal cell differentiation" NARROW []
synonym: "positive regulation of hypodermal cell differentiation" RELATED [GOC:kmv, GOC:rk]
synonym: "stimulation of epidermal cell differentiation" NARROW []
synonym: "up regulation of epidermal cell differentiation" EXACT []
synonym: "up-regulation of epidermal cell differentiation" EXACT []
synonym: "upregulation of epidermal cell differentiation" EXACT []
is_a: GO:0030858 ! positive regulation of epithelial cell differentiation
is_a: GO:0045604 ! regulation of epidermal cell differentiation
is_a: GO:0045684 ! positive regulation of epidermis development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009913 ! epidermal cell differentiation
relationship: positively_regulates GO:0009913 ! epidermal cell differentiation

[Term]
id: GO:0045607
name: regulation of auditory receptor cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of auditory hair cell differentiation." [GOC:go_curators]
synonym: "regulation of auditory hair cell differentiation" EXACT []
is_a: GO:0045604 ! regulation of epidermal cell differentiation
is_a: GO:2000980 ! regulation of inner ear receptor cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042491 ! auditory receptor cell differentiation
relationship: regulates GO:0042491 ! auditory receptor cell differentiation

[Term]
id: GO:0045608
name: negative regulation of auditory receptor cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of auditory hair cell differentiation." [GOC:go_curators]
synonym: "down regulation of auditory receptor cell differentiation" EXACT []
synonym: "down-regulation of auditory receptor cell differentiation" EXACT []
synonym: "downregulation of auditory receptor cell differentiation" EXACT []
synonym: "inhibition of auditory receptor cell differentiation" NARROW []
synonym: "negative regulation of auditory hair cell differentiation" EXACT []
is_a: GO:0002085 ! inhibition of neuroepithelial cell differentiation
is_a: GO:0045605 ! negative regulation of epidermal cell differentiation
is_a: GO:0045607 ! regulation of auditory receptor cell differentiation
is_a: GO:2000981 ! negative regulation of inner ear receptor cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042491 ! auditory receptor cell differentiation
relationship: negatively_regulates GO:0042491 ! auditory receptor cell differentiation

[Term]
id: GO:0045609
name: positive regulation of auditory receptor cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of auditory hair cell differentiation." [GOC:go_curators]
synonym: "activation of auditory receptor cell differentiation" NARROW []
synonym: "positive regulation of auditory hair cell differentiation" EXACT []
synonym: "stimulation of auditory receptor cell differentiation" NARROW []
synonym: "up regulation of auditory receptor cell differentiation" EXACT []
synonym: "up-regulation of auditory receptor cell differentiation" EXACT []
synonym: "upregulation of auditory receptor cell differentiation" EXACT []
is_a: GO:0045606 ! positive regulation of epidermal cell differentiation
is_a: GO:0045607 ! regulation of auditory receptor cell differentiation
is_a: GO:1902913 ! positive regulation of neuroepithelial cell differentiation
is_a: GO:2000982 ! positive regulation of inner ear receptor cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042491 ! auditory receptor cell differentiation
relationship: positively_regulates GO:0042491 ! auditory receptor cell differentiation

[Term]
id: GO:0045610
name: regulation of hemocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hemocyte differentiation." [GOC:go_curators]
synonym: "regulation of arthropod blood cell differentiation" EXACT []
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042386 ! hemocyte differentiation
relationship: regulates GO:0042386 ! hemocyte differentiation

[Term]
id: GO:0045611
name: negative regulation of hemocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of hemocyte differentiation." [GOC:go_curators]
synonym: "down regulation of hemocyte differentiation" EXACT []
synonym: "down-regulation of hemocyte differentiation" EXACT []
synonym: "downregulation of hemocyte differentiation" EXACT []
synonym: "inhibition of hemocyte differentiation" NARROW []
synonym: "negative regulation of arthropod blood cell differentiation" EXACT []
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0045610 ! regulation of hemocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042386 ! hemocyte differentiation
relationship: negatively_regulates GO:0042386 ! hemocyte differentiation

[Term]
id: GO:0045612
name: positive regulation of hemocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hemocyte differentiation." [GOC:go_curators]
synonym: "activation of hemocyte differentiation" NARROW []
synonym: "positive regulation of arthropod blood cell differentiation" EXACT []
synonym: "stimulation of hemocyte differentiation" NARROW []
synonym: "up regulation of hemocyte differentiation" EXACT []
synonym: "up-regulation of hemocyte differentiation" EXACT []
synonym: "upregulation of hemocyte differentiation" EXACT []
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0045610 ! regulation of hemocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042386 ! hemocyte differentiation
relationship: positively_regulates GO:0042386 ! hemocyte differentiation

[Term]
id: GO:0045613
name: regulation of plasmatocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of plasmatocyte differentiation." [GOC:go_curators]
is_a: GO:0045610 ! regulation of hemocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042387 ! plasmatocyte differentiation
relationship: regulates GO:0042387 ! plasmatocyte differentiation

[Term]
id: GO:0045614
name: negative regulation of plasmatocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of plasmatocyte differentiation." [GOC:go_curators]
synonym: "down regulation of plasmatocyte differentiation" EXACT []
synonym: "down-regulation of plasmatocyte differentiation" EXACT []
synonym: "downregulation of plasmatocyte differentiation" EXACT []
synonym: "inhibition of plasmatocyte differentiation" NARROW []
is_a: GO:0045611 ! negative regulation of hemocyte differentiation
is_a: GO:0045613 ! regulation of plasmatocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042387 ! plasmatocyte differentiation
relationship: negatively_regulates GO:0042387 ! plasmatocyte differentiation

[Term]
id: GO:0045615
name: positive regulation of plasmatocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of plasmatocyte differentiation." [GOC:go_curators]
synonym: "activation of plasmatocyte differentiation" NARROW []
synonym: "stimulation of plasmatocyte differentiation" NARROW []
synonym: "up regulation of plasmatocyte differentiation" EXACT []
synonym: "up-regulation of plasmatocyte differentiation" EXACT []
synonym: "upregulation of plasmatocyte differentiation" EXACT []
is_a: GO:0045612 ! positive regulation of hemocyte differentiation
is_a: GO:0045613 ! regulation of plasmatocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042387 ! plasmatocyte differentiation
relationship: positively_regulates GO:0042387 ! plasmatocyte differentiation

[Term]
id: GO:0045616
name: regulation of keratinocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of keratinocyte differentiation." [GOC:go_curators]
is_a: GO:0045604 ! regulation of epidermal cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030216 ! keratinocyte differentiation
relationship: regulates GO:0030216 ! keratinocyte differentiation

[Term]
id: GO:0045617
name: negative regulation of keratinocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of keratinocyte differentiation." [GOC:go_curators]
synonym: "down regulation of keratinocyte differentiation" EXACT []
synonym: "down-regulation of keratinocyte differentiation" EXACT []
synonym: "downregulation of keratinocyte differentiation" EXACT []
synonym: "inhibition of keratinocyte differentiation" NARROW []
is_a: GO:0045605 ! negative regulation of epidermal cell differentiation
is_a: GO:0045616 ! regulation of keratinocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030216 ! keratinocyte differentiation
relationship: negatively_regulates GO:0030216 ! keratinocyte differentiation

[Term]
id: GO:0045618
name: positive regulation of keratinocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of keratinocyte differentiation." [GOC:go_curators]
synonym: "activation of keratinocyte differentiation" NARROW []
synonym: "stimulation of keratinocyte differentiation" NARROW []
synonym: "up regulation of keratinocyte differentiation" EXACT []
synonym: "up-regulation of keratinocyte differentiation" EXACT []
synonym: "upregulation of keratinocyte differentiation" EXACT []
is_a: GO:0045606 ! positive regulation of epidermal cell differentiation
is_a: GO:0045616 ! regulation of keratinocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030216 ! keratinocyte differentiation
relationship: positively_regulates GO:0030216 ! keratinocyte differentiation

[Term]
id: GO:0045619
name: regulation of lymphocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lymphocyte differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "regulation of lymphocyte development" RELATED [GOC:add]
is_a: GO:0051249 ! regulation of lymphocyte activation
is_a: GO:1902105 ! regulation of leukocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030098 ! lymphocyte differentiation
relationship: regulates GO:0030098 ! lymphocyte differentiation

[Term]
id: GO:0045620
name: negative regulation of lymphocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "down regulation of lymphocyte differentiation" EXACT []
synonym: "down-regulation of lymphocyte differentiation" EXACT []
synonym: "downregulation of lymphocyte differentiation" EXACT []
synonym: "inhibition of lymphocyte differentiation" NARROW []
synonym: "negative regulation of lymphocyte development" RELATED [GOC:add]
is_a: GO:0045619 ! regulation of lymphocyte differentiation
is_a: GO:0051250 ! negative regulation of lymphocyte activation
is_a: GO:1902106 ! negative regulation of leukocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030098 ! lymphocyte differentiation
relationship: negatively_regulates GO:0030098 ! lymphocyte differentiation

[Term]
id: GO:0045621
name: positive regulation of lymphocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lymphocyte differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "activation of lymphocyte differentiation" NARROW []
synonym: "positive regulation of lymphocyte development" RELATED [GOC:add]
synonym: "stimulation of lymphocyte differentiation" NARROW []
synonym: "up regulation of lymphocyte differentiation" EXACT []
synonym: "up-regulation of lymphocyte differentiation" EXACT []
synonym: "upregulation of lymphocyte differentiation" EXACT []
is_a: GO:0045619 ! regulation of lymphocyte differentiation
is_a: GO:0051251 ! positive regulation of lymphocyte activation
is_a: GO:1902107 ! positive regulation of leukocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030098 ! lymphocyte differentiation
relationship: positively_regulates GO:0030098 ! lymphocyte differentiation

[Term]
id: GO:0045622
name: regulation of T-helper cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of T-helper cell differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "regulation of T-helper cell development" RELATED [GOC:add]
is_a: GO:0002697 ! regulation of immune effector process
is_a: GO:0043370 ! regulation of CD4-positive, alpha-beta T cell differentiation
is_a: GO:0050776 ! regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042093 ! T-helper cell differentiation
relationship: regulates GO:0042093 ! T-helper cell differentiation

[Term]
id: GO:0045623
name: negative regulation of T-helper cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper cell differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "down regulation of T-helper cell differentiation" EXACT []
synonym: "down-regulation of T-helper cell differentiation" EXACT []
synonym: "downregulation of T-helper cell differentiation" EXACT []
synonym: "inhibition of T-helper cell differentiation" NARROW []
synonym: "negative regulation of T-helper cell development" RELATED [GOC:add]
is_a: GO:0002698 ! negative regulation of immune effector process
is_a: GO:0043371 ! negative regulation of CD4-positive, alpha-beta T cell differentiation
is_a: GO:0045622 ! regulation of T-helper cell differentiation
is_a: GO:0050777 ! negative regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042093 ! T-helper cell differentiation
relationship: negatively_regulates GO:0042093 ! T-helper cell differentiation

[Term]
id: GO:0045624
name: positive regulation of T-helper cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T-helper cell differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "activation of T-helper cell differentiation" NARROW []
synonym: "positive regulation of T-helper cell development" RELATED [GOC:add]
synonym: "stimulation of T-helper cell differentiation" NARROW []
synonym: "up regulation of T-helper cell differentiation" EXACT []
synonym: "up-regulation of T-helper cell differentiation" EXACT []
synonym: "upregulation of T-helper cell differentiation" EXACT []
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0043372 ! positive regulation of CD4-positive, alpha-beta T cell differentiation
is_a: GO:0045622 ! regulation of T-helper cell differentiation
is_a: GO:0050778 ! positive regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042093 ! T-helper cell differentiation
relationship: positively_regulates GO:0042093 ! T-helper cell differentiation

[Term]
id: GO:0045625
name: regulation of T-helper 1 cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of T-helper 1 cell differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "regulation of T-helper 1 cell development" RELATED [GOC:add]
is_a: GO:0002825 ! regulation of T-helper 1 type immune response
is_a: GO:0045622 ! regulation of T-helper cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045063 ! T-helper 1 cell differentiation
relationship: regulates GO:0045063 ! T-helper 1 cell differentiation

[Term]
id: GO:0045626
name: negative regulation of T-helper 1 cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper 1 cell differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "down regulation of T-helper 1 cell differentiation" EXACT []
synonym: "down-regulation of T-helper 1 cell differentiation" EXACT []
synonym: "downregulation of T-helper 1 cell differentiation" EXACT []
synonym: "inhibition of T-helper 1 cell differentiation" NARROW []
synonym: "negative regulation of T-helper 1 cell development" RELATED [GOC:add]
is_a: GO:0002826 ! negative regulation of T-helper 1 type immune response
is_a: GO:0045623 ! negative regulation of T-helper cell differentiation
is_a: GO:0045625 ! regulation of T-helper 1 cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045063 ! T-helper 1 cell differentiation
relationship: negatively_regulates GO:0045063 ! T-helper 1 cell differentiation

[Term]
id: GO:0045627
name: positive regulation of T-helper 1 cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T-helper 1 cell differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "activation of T-helper 1 cell differentiation" NARROW []
synonym: "positive regulation of T-helper 1 cell development" RELATED [GOC:add]
synonym: "stimulation of T-helper 1 cell differentiation" NARROW []
synonym: "up regulation of T-helper 1 cell differentiation" EXACT []
synonym: "up-regulation of T-helper 1 cell differentiation" EXACT []
synonym: "upregulation of T-helper 1 cell differentiation" EXACT []
is_a: GO:0002827 ! positive regulation of T-helper 1 type immune response
is_a: GO:0045624 ! positive regulation of T-helper cell differentiation
is_a: GO:0045625 ! regulation of T-helper 1 cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045063 ! T-helper 1 cell differentiation
relationship: positively_regulates GO:0045063 ! T-helper 1 cell differentiation

[Term]
id: GO:0045628
name: regulation of T-helper 2 cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of T-helper 2 cell differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "regulation of T-helper 2 cell development" RELATED [GOC:add]
is_a: GO:0002828 ! regulation of type 2 immune response
is_a: GO:0045622 ! regulation of T-helper cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045064 ! T-helper 2 cell differentiation
relationship: regulates GO:0045064 ! T-helper 2 cell differentiation

[Term]
id: GO:0045629
name: negative regulation of T-helper 2 cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper 2 cell differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "down regulation of T-helper 2 cell differentiation" EXACT []
synonym: "down-regulation of T-helper 2 cell differentiation" EXACT []
synonym: "downregulation of T-helper 2 cell differentiation" EXACT []
synonym: "inhibition of T-helper 2 cell differentiation" NARROW []
synonym: "negative regulation of T-helper 2 cell development" RELATED [GOC:add]
is_a: GO:0002829 ! negative regulation of type 2 immune response
is_a: GO:0045623 ! negative regulation of T-helper cell differentiation
is_a: GO:0045628 ! regulation of T-helper 2 cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045064 ! T-helper 2 cell differentiation
relationship: negatively_regulates GO:0045064 ! T-helper 2 cell differentiation

[Term]
id: GO:0045630
name: positive regulation of T-helper 2 cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T-helper 2 cell differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "activation of T-helper 2 cell differentiation" NARROW []
synonym: "positive regulation of T-helper 2 cell development" RELATED [GOC:add]
synonym: "stimulation of T-helper 2 cell differentiation" NARROW []
synonym: "up regulation of T-helper 2 cell differentiation" EXACT []
synonym: "up-regulation of T-helper 2 cell differentiation" EXACT []
synonym: "upregulation of T-helper 2 cell differentiation" EXACT []
is_a: GO:0002830 ! positive regulation of type 2 immune response
is_a: GO:0045624 ! positive regulation of T-helper cell differentiation
is_a: GO:0045628 ! regulation of T-helper 2 cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045064 ! T-helper 2 cell differentiation
relationship: positively_regulates GO:0045064 ! T-helper 2 cell differentiation

[Term]
id: GO:0045631
name: regulation of mechanoreceptor differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mechanoreceptor differentiation." [GOC:go_curators]
is_a: GO:0045664 ! regulation of neuron differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042490 ! mechanoreceptor differentiation
relationship: regulates GO:0042490 ! mechanoreceptor differentiation

[Term]
id: GO:0045632
name: negative regulation of mechanoreceptor differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mechanoreceptor differentiation." [GOC:go_curators]
synonym: "down regulation of mechanoreceptor differentiation" EXACT []
synonym: "down-regulation of mechanoreceptor differentiation" EXACT []
synonym: "downregulation of mechanoreceptor differentiation" EXACT []
synonym: "inhibition of mechanoreceptor differentiation" NARROW []
is_a: GO:0045631 ! regulation of mechanoreceptor differentiation
is_a: GO:0045665 ! negative regulation of neuron differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042490 ! mechanoreceptor differentiation
relationship: negatively_regulates GO:0042490 ! mechanoreceptor differentiation

[Term]
id: GO:0045633
name: positive regulation of mechanoreceptor differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mechanoreceptor differentiation." [GOC:go_curators]
synonym: "activation of mechanoreceptor differentiation" NARROW []
synonym: "stimulation of mechanoreceptor differentiation" NARROW []
synonym: "up regulation of mechanoreceptor differentiation" EXACT []
synonym: "up-regulation of mechanoreceptor differentiation" EXACT []
synonym: "upregulation of mechanoreceptor differentiation" EXACT []
is_a: GO:0045631 ! regulation of mechanoreceptor differentiation
is_a: GO:0045666 ! positive regulation of neuron differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042490 ! mechanoreceptor differentiation
relationship: positively_regulates GO:0042490 ! mechanoreceptor differentiation

[Term]
id: GO:0045634
name: regulation of melanocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of melanocyte differentiation." [GOC:go_curators]
synonym: "regulation of melanophore differentiation" EXACT []
is_a: GO:0030856 ! regulation of epithelial cell differentiation
is_a: GO:0050932 ! regulation of pigment cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030318 ! melanocyte differentiation
relationship: regulates GO:0030318 ! melanocyte differentiation

[Term]
id: GO:0045635
name: negative regulation of melanocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of melanocyte differentiation." [GOC:go_curators]
synonym: "down regulation of melanocyte differentiation" EXACT []
synonym: "down-regulation of melanocyte differentiation" EXACT []
synonym: "downregulation of melanocyte differentiation" EXACT []
synonym: "inhibition of melanocyte differentiation" NARROW []
synonym: "negative regulation of melanophore differentiation" EXACT []
is_a: GO:0002085 ! inhibition of neuroepithelial cell differentiation
is_a: GO:0045634 ! regulation of melanocyte differentiation
is_a: GO:0050941 ! negative regulation of pigment cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030318 ! melanocyte differentiation
relationship: negatively_regulates GO:0030318 ! melanocyte differentiation

[Term]
id: GO:0045636
name: positive regulation of melanocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of melanocyte differentiation." [GOC:go_curators]
synonym: "activation of melanocyte differentiation" NARROW []
synonym: "positive regulation of melanophore differentiation" EXACT []
synonym: "stimulation of melanocyte differentiation" NARROW []
synonym: "up regulation of melanocyte differentiation" EXACT []
synonym: "up-regulation of melanocyte differentiation" EXACT []
synonym: "upregulation of melanocyte differentiation" EXACT []
is_a: GO:0045634 ! regulation of melanocyte differentiation
is_a: GO:0050942 ! positive regulation of pigment cell differentiation
is_a: GO:1902913 ! positive regulation of neuroepithelial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030318 ! melanocyte differentiation
relationship: positively_regulates GO:0030318 ! melanocyte differentiation

[Term]
id: GO:0045637
name: regulation of myeloid cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of myeloid cell differentiation." [GOC:go_curators]
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:1903706 ! regulation of hemopoiesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030099 ! myeloid cell differentiation
relationship: regulates GO:0030099 ! myeloid cell differentiation

[Term]
id: GO:0045638
name: negative regulation of myeloid cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation." [GOC:go_curators]
synonym: "down regulation of myeloid cell differentiation" EXACT []
synonym: "down-regulation of myeloid cell differentiation" EXACT []
synonym: "downregulation of myeloid cell differentiation" EXACT []
synonym: "inhibition of myeloid cell differentiation" NARROW []
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0045637 ! regulation of myeloid cell differentiation
is_a: GO:1903707 ! negative regulation of hemopoiesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030099 ! myeloid cell differentiation
relationship: negatively_regulates GO:0030099 ! myeloid cell differentiation

[Term]
id: GO:0045639
name: positive regulation of myeloid cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of myeloid cell differentiation." [GOC:go_curators]
synonym: "activation of myeloid cell differentiation" NARROW []
synonym: "stimulation of myeloid cell differentiation" NARROW []
synonym: "up regulation of myeloid cell differentiation" EXACT []
synonym: "up-regulation of myeloid cell differentiation" EXACT []
synonym: "upregulation of myeloid cell differentiation" EXACT []
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0045637 ! regulation of myeloid cell differentiation
is_a: GO:1903708 ! positive regulation of hemopoiesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030099 ! myeloid cell differentiation
relationship: positively_regulates GO:0030099 ! myeloid cell differentiation

[Term]
id: GO:0045640
name: regulation of basophil differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of basophil differentiation." [GOC:go_curators]
is_a: GO:0030852 ! regulation of granulocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030221 ! basophil differentiation
relationship: regulates GO:0030221 ! basophil differentiation

[Term]
id: GO:0045641
name: negative regulation of basophil differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of basophil differentiation." [GOC:go_curators]
synonym: "down regulation of basophil differentiation" EXACT []
synonym: "down-regulation of basophil differentiation" EXACT []
synonym: "downregulation of basophil differentiation" EXACT []
synonym: "inhibition of basophil differentiation" NARROW []
is_a: GO:0030853 ! negative regulation of granulocyte differentiation
is_a: GO:0045640 ! regulation of basophil differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030221 ! basophil differentiation
relationship: negatively_regulates GO:0030221 ! basophil differentiation

[Term]
id: GO:0045642
name: positive regulation of basophil differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of basophil differentiation." [GOC:go_curators]
synonym: "activation of basophil differentiation" NARROW []
synonym: "stimulation of basophil differentiation" NARROW []
synonym: "up regulation of basophil differentiation" EXACT []
synonym: "up-regulation of basophil differentiation" EXACT []
synonym: "upregulation of basophil differentiation" EXACT []
is_a: GO:0030854 ! positive regulation of granulocyte differentiation
is_a: GO:0045640 ! regulation of basophil differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030221 ! basophil differentiation
relationship: positively_regulates GO:0030221 ! basophil differentiation

[Term]
id: GO:0045643
name: regulation of eosinophil differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of eosinophil differentiation." [GOC:go_curators]
is_a: GO:0030852 ! regulation of granulocyte differentiation
is_a: GO:0060284 ! regulation of cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030222 ! eosinophil differentiation
relationship: regulates GO:0030222 ! eosinophil differentiation

[Term]
id: GO:0045644
name: negative regulation of eosinophil differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of eosinophil differentiation." [GOC:go_curators]
synonym: "down regulation of eosinophil differentiation" EXACT []
synonym: "down-regulation of eosinophil differentiation" EXACT []
synonym: "downregulation of eosinophil differentiation" EXACT []
synonym: "inhibition of eosinophil differentiation" NARROW []
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0030853 ! negative regulation of granulocyte differentiation
is_a: GO:0045643 ! regulation of eosinophil differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030222 ! eosinophil differentiation
relationship: negatively_regulates GO:0030222 ! eosinophil differentiation

[Term]
id: GO:0045645
name: positive regulation of eosinophil differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of eosinophil differentiation." [GOC:go_curators]
synonym: "activation of eosinophil differentiation" NARROW []
synonym: "stimulation of eosinophil differentiation" NARROW []
synonym: "up regulation of eosinophil differentiation" EXACT []
synonym: "up-regulation of eosinophil differentiation" EXACT []
synonym: "upregulation of eosinophil differentiation" EXACT []
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0030854 ! positive regulation of granulocyte differentiation
is_a: GO:0045643 ! regulation of eosinophil differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030222 ! eosinophil differentiation
relationship: positively_regulates GO:0030222 ! eosinophil differentiation

[Term]
id: GO:0045646
name: regulation of erythrocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of erythrocyte differentiation." [GOC:go_curators]
synonym: "regulation of RBC differentiation" EXACT [CL:0000232]
synonym: "regulation of red blood cell differentiation" EXACT [CL:0000232]
is_a: GO:0032844 ! regulation of homeostatic process
is_a: GO:0045637 ! regulation of myeloid cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030218 ! erythrocyte differentiation
relationship: regulates GO:0030218 ! erythrocyte differentiation

[Term]
id: GO:0045647
name: negative regulation of erythrocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of erythrocyte differentiation." [GOC:go_curators]
synonym: "down regulation of erythrocyte differentiation" EXACT []
synonym: "down-regulation of erythrocyte differentiation" EXACT []
synonym: "downregulation of erythrocyte differentiation" EXACT []
synonym: "inhibition of erythrocyte differentiation" NARROW []
synonym: "negative regulation of RBC differentiation" EXACT [CL:0000232]
synonym: "negative regulation of red blood cell differentiation" EXACT [CL:0000232]
is_a: GO:0032845 ! negative regulation of homeostatic process
is_a: GO:0045638 ! negative regulation of myeloid cell differentiation
is_a: GO:0045646 ! regulation of erythrocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030218 ! erythrocyte differentiation
relationship: negatively_regulates GO:0030218 ! erythrocyte differentiation

[Term]
id: GO:0045648
name: positive regulation of erythrocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation." [GOC:go_curators]
synonym: "activation of erythrocyte differentiation" NARROW []
synonym: "positive regulation of RBC differentiation" EXACT [CL:0000232]
synonym: "positive regulation of red blood cell differentiation" EXACT [CL:0000232]
synonym: "stimulation of erythrocyte differentiation" NARROW []
synonym: "up regulation of erythrocyte differentiation" EXACT []
synonym: "up-regulation of erythrocyte differentiation" EXACT []
synonym: "upregulation of erythrocyte differentiation" EXACT []
is_a: GO:0032846 ! positive regulation of homeostatic process
is_a: GO:0045639 ! positive regulation of myeloid cell differentiation
is_a: GO:0045646 ! regulation of erythrocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030218 ! erythrocyte differentiation
relationship: positively_regulates GO:0030218 ! erythrocyte differentiation

[Term]
id: GO:0045649
name: regulation of macrophage differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of macrophage differentiation." [GOC:go_curators]
is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030225 ! macrophage differentiation
relationship: regulates GO:0030225 ! macrophage differentiation

[Term]
id: GO:0045650
name: negative regulation of macrophage differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage differentiation." [GOC:go_curators]
synonym: "down regulation of macrophage differentiation" EXACT []
synonym: "down-regulation of macrophage differentiation" EXACT []
synonym: "downregulation of macrophage differentiation" EXACT []
synonym: "inhibition of macrophage differentiation" NARROW []
is_a: GO:0002762 ! negative regulation of myeloid leukocyte differentiation
is_a: GO:0045649 ! regulation of macrophage differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030225 ! macrophage differentiation
relationship: negatively_regulates GO:0030225 ! macrophage differentiation

[Term]
id: GO:0045651
name: positive regulation of macrophage differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of macrophage differentiation." [GOC:go_curators]
synonym: "activation of macrophage differentiation" NARROW []
synonym: "stimulation of macrophage differentiation" NARROW []
synonym: "up regulation of macrophage differentiation" EXACT []
synonym: "up-regulation of macrophage differentiation" EXACT []
synonym: "upregulation of macrophage differentiation" EXACT []
is_a: GO:0002763 ! positive regulation of myeloid leukocyte differentiation
is_a: GO:0045649 ! regulation of macrophage differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030225 ! macrophage differentiation
relationship: positively_regulates GO:0030225 ! macrophage differentiation

[Term]
id: GO:0045652
name: regulation of megakaryocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of megakaryocyte differentiation." [GOC:go_curators]
is_a: GO:0045637 ! regulation of myeloid cell differentiation
is_a: GO:1901532 ! regulation of hematopoietic progenitor cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030219 ! megakaryocyte differentiation
relationship: regulates GO:0030219 ! megakaryocyte differentiation

[Term]
id: GO:0045653
name: negative regulation of megakaryocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of megakaryocyte differentiation." [GOC:go_curators]
synonym: "down regulation of megakaryocyte differentiation" EXACT []
synonym: "down-regulation of megakaryocyte differentiation" EXACT []
synonym: "downregulation of megakaryocyte differentiation" EXACT []
synonym: "inhibition of megakaryocyte differentiation" NARROW []
is_a: GO:0045638 ! negative regulation of myeloid cell differentiation
is_a: GO:0045652 ! regulation of megakaryocyte differentiation
is_a: GO:1901533 ! negative regulation of hematopoietic progenitor cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030219 ! megakaryocyte differentiation
relationship: negatively_regulates GO:0030219 ! megakaryocyte differentiation

[Term]
id: GO:0045654
name: positive regulation of megakaryocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation." [GOC:go_curators]
synonym: "activation of megakaryocyte differentiation" NARROW []
synonym: "stimulation of megakaryocyte differentiation" NARROW []
synonym: "up regulation of megakaryocyte differentiation" EXACT []
synonym: "up-regulation of megakaryocyte differentiation" EXACT []
synonym: "upregulation of megakaryocyte differentiation" EXACT []
is_a: GO:0045639 ! positive regulation of myeloid cell differentiation
is_a: GO:0045652 ! regulation of megakaryocyte differentiation
is_a: GO:1901534 ! positive regulation of hematopoietic progenitor cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030219 ! megakaryocyte differentiation
relationship: positively_regulates GO:0030219 ! megakaryocyte differentiation

[Term]
id: GO:0045655
name: regulation of monocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of monocyte differentiation." [GOC:go_curators]
is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030224 ! monocyte differentiation
relationship: regulates GO:0030224 ! monocyte differentiation

[Term]
id: GO:0045656
name: negative regulation of monocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of monocyte differentiation." [GOC:go_curators]
synonym: "down regulation of monocyte differentiation" EXACT []
synonym: "down-regulation of monocyte differentiation" EXACT []
synonym: "downregulation of monocyte differentiation" EXACT []
synonym: "inhibition of monocyte differentiation" NARROW []
is_a: GO:0002762 ! negative regulation of myeloid leukocyte differentiation
is_a: GO:0045655 ! regulation of monocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030224 ! monocyte differentiation
relationship: negatively_regulates GO:0030224 ! monocyte differentiation

[Term]
id: GO:0045657
name: positive regulation of monocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of monocyte differentiation." [GOC:go_curators]
synonym: "activation of monocyte differentiation" NARROW []
synonym: "stimulation of monocyte differentiation" NARROW []
synonym: "up regulation of monocyte differentiation" EXACT []
synonym: "up-regulation of monocyte differentiation" EXACT []
synonym: "upregulation of monocyte differentiation" EXACT []
is_a: GO:0002763 ! positive regulation of myeloid leukocyte differentiation
is_a: GO:0045655 ! regulation of monocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030224 ! monocyte differentiation
relationship: positively_regulates GO:0030224 ! monocyte differentiation

[Term]
id: GO:0045658
name: regulation of neutrophil differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neutrophil differentiation." [GOC:go_curators]
is_a: GO:0030852 ! regulation of granulocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030223 ! neutrophil differentiation
relationship: regulates GO:0030223 ! neutrophil differentiation

[Term]
id: GO:0045659
name: negative regulation of neutrophil differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neutrophil differentiation." [GOC:go_curators]
synonym: "down regulation of neutrophil differentiation" EXACT []
synonym: "down-regulation of neutrophil differentiation" EXACT []
synonym: "downregulation of neutrophil differentiation" EXACT []
synonym: "inhibition of neutrophil differentiation" NARROW []
is_a: GO:0030853 ! negative regulation of granulocyte differentiation
is_a: GO:0045658 ! regulation of neutrophil differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030223 ! neutrophil differentiation
relationship: negatively_regulates GO:0030223 ! neutrophil differentiation

[Term]
id: GO:0045660
name: positive regulation of neutrophil differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neutrophil differentiation." [GOC:go_curators]
synonym: "activation of neutrophil differentiation" NARROW []
synonym: "stimulation of neutrophil differentiation" NARROW []
synonym: "up regulation of neutrophil differentiation" EXACT []
synonym: "up-regulation of neutrophil differentiation" EXACT []
synonym: "upregulation of neutrophil differentiation" EXACT []
is_a: GO:0030854 ! positive regulation of granulocyte differentiation
is_a: GO:0045658 ! regulation of neutrophil differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030223 ! neutrophil differentiation
relationship: positively_regulates GO:0030223 ! neutrophil differentiation

[Term]
id: GO:0045661
name: regulation of myoblast differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:go_curators, GOC:mtg_muscle]
is_a: GO:0051147 ! regulation of muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045445 ! myoblast differentiation
relationship: regulates GO:0045445 ! myoblast differentiation

[Term]
id: GO:0045662
name: negative regulation of myoblast differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:go_curators, GOC:mtg_muscle]
synonym: "down regulation of myoblast differentiation" EXACT []
synonym: "down-regulation of myoblast differentiation" EXACT []
synonym: "downregulation of myoblast differentiation" EXACT []
synonym: "inhibition of myoblast differentiation" NARROW []
is_a: GO:0045661 ! regulation of myoblast differentiation
is_a: GO:0051148 ! negative regulation of muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045445 ! myoblast differentiation
relationship: negatively_regulates GO:0045445 ! myoblast differentiation

[Term]
id: GO:0045663
name: positive regulation of myoblast differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:go_curators, GOC:mtg_muscle]
synonym: "activation of myoblast differentiation" NARROW []
synonym: "stimulation of myoblast differentiation" NARROW []
synonym: "up regulation of myoblast differentiation" EXACT []
synonym: "up-regulation of myoblast differentiation" EXACT []
synonym: "upregulation of myoblast differentiation" EXACT []
is_a: GO:0045661 ! regulation of myoblast differentiation
is_a: GO:0051149 ! positive regulation of muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045445 ! myoblast differentiation
relationship: positively_regulates GO:0045445 ! myoblast differentiation

[Term]
id: GO:0045664
name: regulation of neuron differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neuron differentiation." [GOC:go_curators]
is_a: GO:0050767 ! regulation of neurogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030182 ! neuron differentiation
relationship: regulates GO:0030182 ! neuron differentiation

[Term]
id: GO:0045665
name: negative regulation of neuron differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation." [GOC:go_curators]
synonym: "down regulation of neuron differentiation" EXACT []
synonym: "down-regulation of neuron differentiation" EXACT []
synonym: "downregulation of neuron differentiation" EXACT []
synonym: "inhibition of neuron differentiation" NARROW []
is_a: GO:0045664 ! regulation of neuron differentiation
is_a: GO:0050768 ! negative regulation of neurogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030182 ! neuron differentiation
relationship: negatively_regulates GO:0030182 ! neuron differentiation

[Term]
id: GO:0045666
name: positive regulation of neuron differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neuron differentiation." [GOC:go_curators]
synonym: "activation of neuron differentiation" NARROW []
synonym: "stimulation of neuron differentiation" NARROW []
synonym: "up regulation of neuron differentiation" EXACT []
synonym: "up-regulation of neuron differentiation" EXACT []
synonym: "upregulation of neuron differentiation" EXACT []
is_a: GO:0045664 ! regulation of neuron differentiation
is_a: GO:0050769 ! positive regulation of neurogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030182 ! neuron differentiation
relationship: positively_regulates GO:0030182 ! neuron differentiation

[Term]
id: GO:0045667
name: regulation of osteoblast differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of osteoblast differentiation." [GOC:go_curators]
is_a: GO:0030278 ! regulation of ossification
is_a: GO:0045595 ! regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001649 ! osteoblast differentiation
relationship: regulates GO:0001649 ! osteoblast differentiation

[Term]
id: GO:0045668
name: negative regulation of osteoblast differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of osteoblast differentiation." [GOC:go_curators]
synonym: "down regulation of osteoblast differentiation" EXACT []
synonym: "down-regulation of osteoblast differentiation" EXACT []
synonym: "downregulation of osteoblast differentiation" EXACT []
synonym: "inhibition of osteoblast differentiation" NARROW []
is_a: GO:0030279 ! negative regulation of ossification
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0045667 ! regulation of osteoblast differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001649 ! osteoblast differentiation
relationship: negatively_regulates GO:0001649 ! osteoblast differentiation

[Term]
id: GO:0045669
name: positive regulation of osteoblast differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of osteoblast differentiation." [GOC:go_curators]
synonym: "activation of osteoblast differentiation" NARROW []
synonym: "stimulation of osteoblast differentiation" NARROW []
synonym: "up regulation of osteoblast differentiation" EXACT []
synonym: "up-regulation of osteoblast differentiation" EXACT []
synonym: "upregulation of osteoblast differentiation" EXACT []
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0045667 ! regulation of osteoblast differentiation
is_a: GO:0045778 ! positive regulation of ossification
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001649 ! osteoblast differentiation
relationship: positively_regulates GO:0001649 ! osteoblast differentiation

[Term]
id: GO:0045670
name: regulation of osteoclast differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of osteoclast differentiation." [GOC:go_curators]
is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030316 ! osteoclast differentiation
relationship: regulates GO:0030316 ! osteoclast differentiation

[Term]
id: GO:0045671
name: negative regulation of osteoclast differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of osteoclast differentiation." [GOC:go_curators]
synonym: "down regulation of osteoclast differentiation" EXACT []
synonym: "down-regulation of osteoclast differentiation" EXACT []
synonym: "downregulation of osteoclast differentiation" EXACT []
synonym: "inhibition of osteoclast differentiation" NARROW []
is_a: GO:0002762 ! negative regulation of myeloid leukocyte differentiation
is_a: GO:0045670 ! regulation of osteoclast differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030316 ! osteoclast differentiation
relationship: negatively_regulates GO:0030316 ! osteoclast differentiation

[Term]
id: GO:0045672
name: positive regulation of osteoclast differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of osteoclast differentiation." [GOC:go_curators]
synonym: "activation of osteoclast differentiation" NARROW []
synonym: "stimulation of osteoclast differentiation" NARROW []
synonym: "up regulation of osteoclast differentiation" EXACT []
synonym: "up-regulation of osteoclast differentiation" EXACT []
synonym: "upregulation of osteoclast differentiation" EXACT []
is_a: GO:0002763 ! positive regulation of myeloid leukocyte differentiation
is_a: GO:0045670 ! regulation of osteoclast differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030316 ! osteoclast differentiation
relationship: positively_regulates GO:0030316 ! osteoclast differentiation

[Term]
id: GO:0045676
name: regulation of R7 cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of R7 differentiation." [GOC:go_curators]
is_a: GO:0046532 ! regulation of photoreceptor cell differentiation
is_a: GO:2000027 ! regulation of organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045466 ! R7 cell differentiation
relationship: regulates GO:0045466 ! R7 cell differentiation

[Term]
id: GO:0045677
name: negative regulation of R7 cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of R7cell differentiation." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "down regulation of R7 differentiation" EXACT []
synonym: "down-regulation of R7 differentiation" EXACT []
synonym: "downregulation of R7 differentiation" EXACT []
synonym: "inhibition of R7 differentiation" NARROW []
synonym: "negative regulation of R7 differentiation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0045676 ! regulation of R7 cell differentiation
is_a: GO:0046533 ! negative regulation of photoreceptor cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045466 ! R7 cell differentiation
relationship: negatively_regulates GO:0045466 ! R7 cell differentiation

[Term]
id: GO:0045678
name: positive regulation of R7 cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of R7 cell differentiation." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "activation of R7 differentiation" NARROW []
synonym: "positive regulation of R7 differentiation" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of R7 differentiation" NARROW []
synonym: "up regulation of R7 differentiation" EXACT []
synonym: "up-regulation of R7 differentiation" EXACT []
synonym: "upregulation of R7 differentiation" EXACT []
is_a: GO:0045676 ! regulation of R7 cell differentiation
is_a: GO:0046534 ! positive regulation of photoreceptor cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045466 ! R7 cell differentiation
relationship: positively_regulates GO:0045466 ! R7 cell differentiation

[Term]
id: GO:0045679
name: regulation of R8 cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of R8 differentiation." [GOC:go_curators]
is_a: GO:0046532 ! regulation of photoreceptor cell differentiation
is_a: GO:2000027 ! regulation of organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045465 ! R8 cell differentiation
relationship: regulates GO:0045465 ! R8 cell differentiation

[Term]
id: GO:0045680
name: negative regulation of R8 cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of R8 cell differentiation." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "down regulation of R8 differentiation" EXACT []
synonym: "down-regulation of R8 differentiation" EXACT []
synonym: "downregulation of R8 differentiation" EXACT []
synonym: "inhibition of R8 differentiation" NARROW []
synonym: "negative regulation of R8 differentiation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0045679 ! regulation of R8 cell differentiation
is_a: GO:0046533 ! negative regulation of photoreceptor cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045465 ! R8 cell differentiation
relationship: negatively_regulates GO:0045465 ! R8 cell differentiation

[Term]
id: GO:0045681
name: positive regulation of R8 cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of R8 cell differentiation." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "activation of R8 differentiation" NARROW []
synonym: "positive regulation of R8 differentiation" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of R8 differentiation" NARROW []
synonym: "up regulation of R8 differentiation" EXACT []
synonym: "up-regulation of R8 differentiation" EXACT []
synonym: "upregulation of R8 differentiation" EXACT []
is_a: GO:0045679 ! regulation of R8 cell differentiation
is_a: GO:0046534 ! positive regulation of photoreceptor cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045465 ! R8 cell differentiation
relationship: positively_regulates GO:0045465 ! R8 cell differentiation

[Term]
id: GO:0045682
name: regulation of epidermis development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of epidermis development." [GOC:go_curators]
synonym: "regulation of epidermal development" EXACT []
synonym: "regulation of hypodermis development" RELATED [GOC:kmv, GOC:rk]
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008544 ! epidermis development
relationship: regulates GO:0008544 ! epidermis development

[Term]
id: GO:0045683
name: negative regulation of epidermis development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of epidermis development." [GOC:go_curators]
synonym: "down regulation of epidermis development" EXACT []
synonym: "down-regulation of epidermis development" EXACT []
synonym: "downregulation of epidermis development" EXACT []
synonym: "inhibition of epidermis development" NARROW []
synonym: "negative regulation of epidermal development" EXACT []
synonym: "negative regulation of hypodermis development" RELATED [GOC:kmv, GOC:rk]
is_a: GO:0045682 ! regulation of epidermis development
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008544 ! epidermis development
relationship: negatively_regulates GO:0008544 ! epidermis development

[Term]
id: GO:0045684
name: positive regulation of epidermis development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of epidermis development." [GOC:go_curators]
synonym: "activation of epidermis development" NARROW []
synonym: "positive regulation of epidermal development" EXACT []
synonym: "positive regulation of hypodermis development" RELATED [GOC:kmv, GOC:rk]
synonym: "stimulation of epidermis development" NARROW []
synonym: "up regulation of epidermis development" EXACT []
synonym: "up-regulation of epidermis development" EXACT []
synonym: "upregulation of epidermis development" EXACT []
is_a: GO:0045682 ! regulation of epidermis development
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008544 ! epidermis development
relationship: positively_regulates GO:0008544 ! epidermis development

[Term]
id: GO:0045685
name: regulation of glial cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glia cell differentiation." [GOC:go_curators]
synonym: "regulation of glia cell differentiation" EXACT []
synonym: "regulation of neuroglia differentiation" EXACT []
is_a: GO:0014013 ! regulation of gliogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010001 ! glial cell differentiation
relationship: regulates GO:0010001 ! glial cell differentiation

[Term]
id: GO:0045686
name: negative regulation of glial cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of glia cell differentiation." [GOC:go_curators]
synonym: "down regulation of glial cell differentiation" EXACT []
synonym: "down-regulation of glial cell differentiation" EXACT []
synonym: "downregulation of glial cell differentiation" EXACT []
synonym: "inhibition of glial cell differentiation" NARROW []
synonym: "negative regulation of glia cell differentiation" EXACT []
synonym: "negative regulation of neuroglia differentiation" EXACT []
is_a: GO:0014014 ! negative regulation of gliogenesis
is_a: GO:0045685 ! regulation of glial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010001 ! glial cell differentiation
relationship: negatively_regulates GO:0010001 ! glial cell differentiation

[Term]
id: GO:0045687
name: positive regulation of glial cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glia cell differentiation." [GOC:go_curators]
synonym: "activation of glial cell differentiation" NARROW []
synonym: "positive regulation of glia cell differentiation" EXACT []
synonym: "positive regulation of neuroglia differentiation" EXACT []
synonym: "stimulation of glial cell differentiation" NARROW []
synonym: "up regulation of glial cell differentiation" EXACT []
synonym: "up-regulation of glial cell differentiation" EXACT []
synonym: "upregulation of glial cell differentiation" EXACT []
is_a: GO:0014015 ! positive regulation of gliogenesis
is_a: GO:0045685 ! regulation of glial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010001 ! glial cell differentiation
relationship: positively_regulates GO:0010001 ! glial cell differentiation

[Term]
id: GO:0045688
name: regulation of antipodal cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of antipodal cell differentiation." [GOC:go_curators, GOC:mtg_plant]
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009557 ! antipodal cell differentiation
relationship: regulates GO:0009557 ! antipodal cell differentiation

[Term]
id: GO:0045689
name: negative regulation of antipodal cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of antipodal cell differentiation." [GOC:go_curators, GOC:mtg_plant]
synonym: "down regulation of antipodal cell differentiation" EXACT []
synonym: "down-regulation of antipodal cell differentiation" EXACT []
synonym: "downregulation of antipodal cell differentiation" EXACT []
synonym: "inhibition of antipodal cell differentiation" NARROW []
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0045688 ! regulation of antipodal cell differentiation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009557 ! antipodal cell differentiation
relationship: negatively_regulates GO:0009557 ! antipodal cell differentiation

[Term]
id: GO:0045690
name: positive regulation of antipodal cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of antipodal cell differentiation." [GOC:go_curators, GOC:mtg_plant]
synonym: "activation of antipodal cell differentiation" NARROW []
synonym: "stimulation of antipodal cell differentiation" NARROW []
synonym: "up regulation of antipodal cell differentiation" EXACT []
synonym: "up-regulation of antipodal cell differentiation" EXACT []
synonym: "upregulation of antipodal cell differentiation" EXACT []
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0045688 ! regulation of antipodal cell differentiation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009557 ! antipodal cell differentiation
relationship: positively_regulates GO:0009557 ! antipodal cell differentiation

[Term]
id: GO:0045691
name: regulation of embryo sac central cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of female gametophyte central cell differentiation." [GOC:go_curators, GOC:mtg_plant]
synonym: "regulation of female gametophyte central cell differentiation" EXACT []
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009559 ! embryo sac central cell differentiation
relationship: regulates GO:0009559 ! embryo sac central cell differentiation

[Term]
id: GO:0045692
name: negative regulation of embryo sac central cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of embryo sac central cell differentiation." [GOC:go_curators, GOC:mtg_plant]
synonym: "down regulation of female gametophyte central cell differentiation" EXACT []
synonym: "down-regulation of female gametophyte central cell differentiation" EXACT []
synonym: "downregulation of female gametophyte central cell differentiation" EXACT []
synonym: "inhibition of female gametophyte central cell differentiation" NARROW []
synonym: "negative regulation of female gametophyte central cell differentiation" EXACT []
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0045691 ! regulation of embryo sac central cell differentiation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009559 ! embryo sac central cell differentiation
relationship: negatively_regulates GO:0009559 ! embryo sac central cell differentiation

[Term]
id: GO:0045693
name: positive regulation of embryo sac central cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of embryo sac central cell differentiation." [GOC:go_curators, GOC:mtg_plant]
synonym: "activation of female gametophyte central cell differentiation" NARROW []
synonym: "positive regulation of female gametophyte central cell differentiation" EXACT []
synonym: "stimulation of female gametophyte central cell differentiation" NARROW []
synonym: "up regulation of female gametophyte central cell differentiation" EXACT []
synonym: "up-regulation of female gametophyte central cell differentiation" EXACT []
synonym: "upregulation of female gametophyte central cell differentiation" EXACT []
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0045691 ! regulation of embryo sac central cell differentiation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009559 ! embryo sac central cell differentiation
relationship: positively_regulates GO:0009559 ! embryo sac central cell differentiation

[Term]
id: GO:0045694
name: regulation of embryo sac egg cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of embryo sac egg cell differentiation." [GOC:go_curators, GOC:mtg_plant]
synonym: "regulation of female gametophyte egg cell differentiation" EXACT []
is_a: GO:0043900 ! regulation of multi-organism process
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:2000026 ! regulation of multicellular organismal development
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009560 ! embryo sac egg cell differentiation
relationship: regulates GO:0009560 ! embryo sac egg cell differentiation

[Term]
id: GO:0045695
name: negative regulation of embryo sac egg cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of embryo sac egg cell differentiation." [GOC:go_curators, GOC:mtg_plant]
synonym: "down regulation of female gametophyte egg cell differentiation" EXACT []
synonym: "down-regulation of female gametophyte egg cell differentiation" EXACT []
synonym: "downregulation of female gametophyte egg cell differentiation" EXACT []
synonym: "inhibition of female gametophyte egg cell differentiation" NARROW []
synonym: "negative regulation of female gametophyte egg cell differentiation" EXACT []
is_a: GO:0043901 ! negative regulation of multi-organism process
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0045694 ! regulation of embryo sac egg cell differentiation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000242 ! negative regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009560 ! embryo sac egg cell differentiation
relationship: negatively_regulates GO:0009560 ! embryo sac egg cell differentiation

[Term]
id: GO:0045696
name: positive regulation of embryo sac egg cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of embryo sac egg cell differentiation." [GOC:go_curators, GOC:mtg_plant]
synonym: "activation of female gametophyte egg cell differentiation" NARROW []
synonym: "positive regulation of female gametophyte egg cell differentiation" EXACT []
synonym: "stimulation of female gametophyte egg cell differentiation" NARROW []
synonym: "up regulation of female gametophyte egg cell differentiation" EXACT []
synonym: "up-regulation of female gametophyte egg cell differentiation" EXACT []
synonym: "upregulation of female gametophyte egg cell differentiation" EXACT []
is_a: GO:0043902 ! positive regulation of multi-organism process
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0045694 ! regulation of embryo sac egg cell differentiation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000243 ! positive regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009560 ! embryo sac egg cell differentiation
relationship: positively_regulates GO:0009560 ! embryo sac egg cell differentiation

[Term]
id: GO:0045697
name: regulation of synergid differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synergid cell differentiation." [GOC:go_curators]
synonym: "regulation of synergid cell differentiation" EXACT []
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009563 ! synergid differentiation
relationship: regulates GO:0009563 ! synergid differentiation

[Term]
id: GO:0045698
name: negative regulation of synergid differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of synergid cell differentiation." [GOC:go_curators]
synonym: "down regulation of synergid differentiation" EXACT []
synonym: "down-regulation of synergid differentiation" EXACT []
synonym: "downregulation of synergid differentiation" EXACT []
synonym: "inhibition of synergid differentiation" NARROW []
synonym: "negative regulation of synergid cell differentiation" EXACT []
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0045697 ! regulation of synergid differentiation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009563 ! synergid differentiation
relationship: negatively_regulates GO:0009563 ! synergid differentiation

[Term]
id: GO:0045699
name: positive regulation of synergid differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of synergid cell differentiation." [GOC:go_curators]
synonym: "activation of synergid differentiation" NARROW []
synonym: "positive regulation of synergid cell differentiation" EXACT []
synonym: "stimulation of synergid differentiation" NARROW []
synonym: "up regulation of synergid differentiation" EXACT []
synonym: "up-regulation of synergid differentiation" EXACT []
synonym: "upregulation of synergid differentiation" EXACT []
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0045697 ! regulation of synergid differentiation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009563 ! synergid differentiation
relationship: positively_regulates GO:0009563 ! synergid differentiation

[Term]
id: GO:0045700
name: regulation of spermatid nuclear differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of spermatid nuclear differentiation." [GOC:go_curators]
is_a: GO:0030856 ! regulation of epithelial cell differentiation
is_a: GO:0043900 ! regulation of multi-organism process
is_a: GO:0060284 ! regulation of cell development
is_a: GO:1903353 ! regulation of nucleus organization
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007289 ! spermatid nucleus differentiation
relationship: regulates GO:0007289 ! spermatid nucleus differentiation

[Term]
id: GO:0045701
name: negative regulation of spermatid nuclear differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of spermatid nuclear differentiation." [GOC:go_curators]
synonym: "down regulation of spermatid nuclear differentiation" EXACT []
synonym: "down-regulation of spermatid nuclear differentiation" EXACT []
synonym: "downregulation of spermatid nuclear differentiation" EXACT []
synonym: "inhibition of spermatid nuclear differentiation" NARROW []
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0043901 ! negative regulation of multi-organism process
is_a: GO:0045700 ! regulation of spermatid nuclear differentiation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000242 ! negative regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007289 ! spermatid nucleus differentiation
relationship: negatively_regulates GO:0007289 ! spermatid nucleus differentiation

[Term]
id: GO:0045702
name: positive regulation of spermatid nuclear differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of spermatid nuclear differentiation." [GOC:go_curators]
synonym: "activation of spermatid nuclear differentiation" NARROW []
synonym: "stimulation of spermatid nuclear differentiation" NARROW []
synonym: "up regulation of spermatid nuclear differentiation" EXACT []
synonym: "up-regulation of spermatid nuclear differentiation" EXACT []
synonym: "upregulation of spermatid nuclear differentiation" EXACT []
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0043902 ! positive regulation of multi-organism process
is_a: GO:0045700 ! regulation of spermatid nuclear differentiation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000243 ! positive regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007289 ! spermatid nucleus differentiation
relationship: positively_regulates GO:0007289 ! spermatid nucleus differentiation

[Term]
id: GO:0045703
name: ketoreductase activity
namespace: molecular_function
def: "Catalysis of the reduction of a ketone group to form the corresponding alcohol." [EC:1.1.-.-]
xref: EC:1.1.-.-
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0045704
name: regulation of salivary gland boundary specification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of salivary gland determination." [GOC:go_curators, GOC:tb]
synonym: "regulation of salivary gland determination" EXACT [GOC:tb]
is_a: GO:0003156 ! regulation of organ formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007432 ! salivary gland boundary specification
relationship: regulates GO:0007432 ! salivary gland boundary specification

[Term]
id: GO:0045705
name: negative regulation of salivary gland boundary specification
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of salivary gland determination." [GOC:go_curators, GOC:tb]
synonym: "down regulation of salivary gland determination" EXACT []
synonym: "down-regulation of salivary gland determination" EXACT []
synonym: "downregulation of salivary gland determination" EXACT []
synonym: "inhibition of salivary gland determination" NARROW []
synonym: "negative regulation of salivary gland determination" EXACT [GOC:tb]
is_a: GO:0045704 ! regulation of salivary gland boundary specification
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007432 ! salivary gland boundary specification
relationship: negatively_regulates GO:0007432 ! salivary gland boundary specification

[Term]
id: GO:0045706
name: positive regulation of salivary gland boundary specification
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of salivary gland determination." [GOC:go_curators, GOC:tb]
synonym: "activation of salivary gland determination" NARROW []
synonym: "positive regulation of salivary gland determination" EXACT [GOC:tb]
synonym: "stimulation of salivary gland determination" NARROW []
synonym: "up regulation of salivary gland determination" EXACT []
synonym: "up-regulation of salivary gland determination" EXACT []
synonym: "upregulation of salivary gland determination" EXACT []
is_a: GO:0045704 ! regulation of salivary gland boundary specification
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007432 ! salivary gland boundary specification
relationship: positively_regulates GO:0007432 ! salivary gland boundary specification

[Term]
id: GO:0045707
name: regulation of adult salivary gland boundary specification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of salivary gland determination in an adult organism." [GOC:go_curators, GOC:tb]
synonym: "regulation of adult salivary gland determination" EXACT [GOC:tb]
is_a: GO:0045704 ! regulation of salivary gland boundary specification
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007434 ! adult salivary gland boundary specification
relationship: regulates GO:0007434 ! adult salivary gland boundary specification

[Term]
id: GO:0045708
name: regulation of larval salivary gland boundary specification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of salivary gland determination in a larval organism." [GOC:go_curators, GOC:tb]
synonym: "regulation of larval salivary gland determination" EXACT [GOC:tb]
is_a: GO:0045704 ! regulation of salivary gland boundary specification
is_a: GO:0048580 ! regulation of post-embryonic development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007433 ! larval salivary gland boundary specification
relationship: regulates GO:0007433 ! larval salivary gland boundary specification

[Term]
id: GO:0045709
name: negative regulation of adult salivary gland boundary specification
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of salivary gland determination in an adult organism." [GOC:go_curators, GOC:tb]
synonym: "down regulation of adult salivary gland determination" EXACT []
synonym: "down-regulation of adult salivary gland determination" EXACT []
synonym: "downregulation of adult salivary gland determination" EXACT []
synonym: "inhibition of adult salivary gland determination" NARROW []
synonym: "negative regulation of adult salivary gland determination" EXACT [GOC:tb]
is_a: GO:0045705 ! negative regulation of salivary gland boundary specification
is_a: GO:0045707 ! regulation of adult salivary gland boundary specification
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007434 ! adult salivary gland boundary specification
relationship: negatively_regulates GO:0007434 ! adult salivary gland boundary specification

[Term]
id: GO:0045710
name: negative regulation of larval salivary gland boundary specification
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of salivary gland determination in a larval organism." [GOC:go_curators, GOC:tb]
synonym: "down regulation of larval salivary gland determination" EXACT []
synonym: "down-regulation of larval salivary gland determination" EXACT []
synonym: "downregulation of larval salivary gland determination" EXACT []
synonym: "inhibition of larval salivary gland determination" NARROW []
synonym: "negative regulation of larval salivary gland determination" EXACT [GOC:tb]
is_a: GO:0045705 ! negative regulation of salivary gland boundary specification
is_a: GO:0045708 ! regulation of larval salivary gland boundary specification
is_a: GO:0048581 ! negative regulation of post-embryonic development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007433 ! larval salivary gland boundary specification
relationship: negatively_regulates GO:0007433 ! larval salivary gland boundary specification

[Term]
id: GO:0045711
name: positive regulation of adult salivary gland boundary specification
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of salivary gland determination in an adult organism." [GOC:go_curators, GOC:tb]
synonym: "activation of adult salivary gland determination" NARROW []
synonym: "positive regulation of adult salivary gland determination" EXACT [GOC:tb]
synonym: "stimulation of adult salivary gland determination" NARROW []
synonym: "up regulation of adult salivary gland determination" EXACT []
synonym: "up-regulation of adult salivary gland determination" EXACT []
synonym: "upregulation of adult salivary gland determination" EXACT []
is_a: GO:0045706 ! positive regulation of salivary gland boundary specification
is_a: GO:0045707 ! regulation of adult salivary gland boundary specification
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007434 ! adult salivary gland boundary specification
relationship: positively_regulates GO:0007434 ! adult salivary gland boundary specification

[Term]
id: GO:0045712
name: positive regulation of larval salivary gland boundary specification
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of salivary gland determination in a larval organism." [GOC:go_curators, GOC:tb]
synonym: "activation of larval salivary gland determination" NARROW []
synonym: "positive regulation of larval salivary gland determination" EXACT [GOC:tb]
synonym: "stimulation of larval salivary gland determination" NARROW []
synonym: "up regulation of larval salivary gland determination" EXACT []
synonym: "up-regulation of larval salivary gland determination" EXACT []
synonym: "upregulation of larval salivary gland determination" EXACT []
is_a: GO:0045706 ! positive regulation of salivary gland boundary specification
is_a: GO:0045708 ! regulation of larval salivary gland boundary specification
is_a: GO:0048582 ! positive regulation of post-embryonic development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007433 ! larval salivary gland boundary specification
relationship: positively_regulates GO:0007433 ! larval salivary gland boundary specification

[Term]
id: GO:0045713
name: low-density lipoprotein particle receptor biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of low-density lipoprotein receptors, cell surface proteins that mediate the endocytosis of low-density lipoprotein particles by cells." [GOC:go_curators]
synonym: "LDLr biosynthesis" EXACT []
synonym: "LDLr biosynthetic process" EXACT []
synonym: "low-density lipoprotein receptor anabolism" EXACT []
synonym: "low-density lipoprotein receptor biosynthesis" EXACT []
synonym: "low-density lipoprotein receptor biosynthetic process" EXACT [GOC:dph]
synonym: "low-density lipoprotein receptor formation" EXACT []
synonym: "low-density lipoprotein receptor synthesis" EXACT []
is_a: GO:0019538 ! protein metabolic process
is_a: GO:0032799 ! low-density lipoprotein receptor particle metabolic process
is_a: GO:0032800 ! receptor biosynthetic process

[Term]
id: GO:0045714
name: regulation of low-density lipoprotein particle receptor biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of low-density lipoprotein particle receptors." [GOC:go_curators]
synonym: "regulation of LDLr biosynthesis" EXACT []
synonym: "regulation of LDLr biosynthetic process" EXACT []
synonym: "regulation of low-density lipoprotein receptor anabolism" EXACT []
synonym: "regulation of low-density lipoprotein receptor biosynthesis" EXACT []
synonym: "regulation of low-density lipoprotein receptor biosynthetic process" EXACT [GOC:dph]
synonym: "regulation of low-density lipoprotein receptor formation" EXACT []
synonym: "regulation of low-density lipoprotein receptor synthesis" EXACT []
is_a: GO:0010869 ! regulation of receptor biosynthetic process
is_a: GO:0051246 ! regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045713 ! low-density lipoprotein particle receptor biosynthetic process
relationship: regulates GO:0045713 ! low-density lipoprotein particle receptor biosynthetic process

[Term]
id: GO:0045715
name: negative regulation of low-density lipoprotein particle receptor biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of low-density lipoprotein particle receptors." [GOC:go_curators]
synonym: "down regulation of low-density lipoprotein receptor biosynthetic process" EXACT []
synonym: "down-regulation of low-density lipoprotein receptor biosynthetic process" EXACT []
synonym: "downregulation of low-density lipoprotein receptor biosynthetic process" EXACT []
synonym: "inhibition of low-density lipoprotein receptor biosynthetic process" NARROW []
synonym: "negative regulation of low-density lipoprotein receptor anabolism" EXACT []
synonym: "negative regulation of low-density lipoprotein receptor biosynthesis" EXACT []
synonym: "negative regulation of low-density lipoprotein receptor biosynthetic process" EXACT [GOC:dph]
synonym: "negative regulation of low-density lipoprotein receptor formation" EXACT []
synonym: "negative regulation of low-density lipoprotein receptor synthesis" EXACT []
is_a: GO:0010871 ! negative regulation of receptor biosynthetic process
is_a: GO:0045714 ! regulation of low-density lipoprotein particle receptor biosynthetic process
is_a: GO:0051248 ! negative regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045713 ! low-density lipoprotein particle receptor biosynthetic process
relationship: negatively_regulates GO:0045713 ! low-density lipoprotein particle receptor biosynthetic process

[Term]
id: GO:0045716
name: positive regulation of low-density lipoprotein particle receptor biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of low-density lipoprotein receptors." [GOC:go_curators]
synonym: "activation of low-density lipoprotein receptor biosynthetic process" NARROW []
synonym: "positive regulation of low-density lipoprotein receptor anabolism" EXACT []
synonym: "positive regulation of low-density lipoprotein receptor biosynthesis" EXACT []
synonym: "positive regulation of low-density lipoprotein receptor biosynthetic process" EXACT [GOC:dph]
synonym: "positive regulation of low-density lipoprotein receptor formation" EXACT []
synonym: "positive regulation of low-density lipoprotein receptor synthesis" EXACT []
synonym: "stimulation of low-density lipoprotein receptor biosynthetic process" NARROW []
synonym: "up regulation of low-density lipoprotein receptor biosynthetic process" EXACT []
synonym: "up-regulation of low-density lipoprotein receptor biosynthetic process" EXACT []
synonym: "upregulation of low-density lipoprotein receptor biosynthetic process" EXACT []
is_a: GO:0010870 ! positive regulation of receptor biosynthetic process
is_a: GO:0045714 ! regulation of low-density lipoprotein particle receptor biosynthetic process
is_a: GO:0051247 ! positive regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045713 ! low-density lipoprotein particle receptor biosynthetic process
relationship: positively_regulates GO:0045713 ! low-density lipoprotein particle receptor biosynthetic process

[Term]
id: GO:0045717
name: negative regulation of fatty acid biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of fatty acid biosynthetic process" EXACT []
synonym: "down-regulation of fatty acid biosynthetic process" EXACT []
synonym: "downregulation of fatty acid biosynthetic process" EXACT []
synonym: "inhibition of fatty acid biosynthetic process" NARROW []
synonym: "negative regulation of fatty acid anabolism" EXACT []
synonym: "negative regulation of fatty acid biosynthesis" EXACT []
synonym: "negative regulation of fatty acid formation" EXACT []
synonym: "negative regulation of fatty acid synthesis" EXACT []
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0042304 ! regulation of fatty acid biosynthetic process
is_a: GO:0045922 ! negative regulation of fatty acid metabolic process
is_a: GO:0051055 ! negative regulation of lipid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006633 ! fatty acid biosynthetic process
relationship: negatively_regulates GO:0006633 ! fatty acid biosynthetic process

[Term]
id: GO:0045718
name: obsolete negative regulation of flagellum assembly
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of a flagellum." [GOC:go_curators]
comment: This term was made obsolete because microtubule-based flagellum (GO:0009434) and motile cilium (GO:0031514), as referenced by this term, were determined to be equivalent and merged. When a merge for this term was considered, it was noticed that both eukaryotic and prokaryotic proteins are annotated to it because its meaning had been ambiguous so obsoletion was considered safest.
synonym: "down regulation of flagellum assembly" EXACT []
synonym: "down-regulation of flagellum assembly" EXACT []
synonym: "downregulation of flagellum assembly" EXACT []
synonym: "inhibition of flagellum assembly" NARROW []
synonym: "negative regulation of flagella assembly" EXACT []
synonym: "negative regulation of flagellum assembly" EXACT []
synonym: "negative regulation of flagellum biogenesis" RELATED [GOC:mah]
is_obsolete: true
consider: GO:1902018

[Term]
id: GO:0045719
name: negative regulation of glycogen biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of glycogen biosynthetic process" EXACT []
synonym: "down-regulation of glycogen biosynthetic process" EXACT []
synonym: "downregulation of glycogen biosynthetic process" EXACT []
synonym: "inhibition of glycogen biosynthetic process" NARROW []
synonym: "negative regulation of glycogen anabolism" EXACT []
synonym: "negative regulation of glycogen biosynthesis" EXACT []
synonym: "negative regulation of glycogen formation" EXACT []
synonym: "negative regulation of glycogen synthesis" EXACT []
is_a: GO:0005979 ! regulation of glycogen biosynthetic process
is_a: GO:0070874 ! negative regulation of glycogen metabolic process
is_a: GO:2000113 ! negative regulation of cellular macromolecule biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0005978 ! glycogen biosynthetic process
relationship: negatively_regulates GO:0005978 ! glycogen biosynthetic process

[Term]
id: GO:0045720
name: negative regulation of integrin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins." [GOC:go_curators]
synonym: "down regulation of integrin biosynthetic process" EXACT []
synonym: "down-regulation of integrin biosynthetic process" EXACT []
synonym: "downregulation of integrin biosynthetic process" EXACT []
synonym: "inhibition of integrin biosynthetic process" NARROW []
synonym: "negative regulation of integrin anabolism" EXACT []
synonym: "negative regulation of integrin biosynthesis" EXACT []
synonym: "negative regulation of integrin formation" EXACT []
synonym: "negative regulation of integrin synthesis" EXACT []
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
is_a: GO:0045113 ! regulation of integrin biosynthetic process
is_a: GO:0051129 ! negative regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045112 ! integrin biosynthetic process
relationship: negatively_regulates GO:0045112 ! integrin biosynthetic process

[Term]
id: GO:0045721
name: negative regulation of gluconeogenesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of gluconeogenesis" EXACT []
synonym: "down-regulation of gluconeogenesis" EXACT []
synonym: "downregulation of gluconeogenesis" EXACT []
synonym: "inhibition of gluconeogenesis" NARROW []
is_a: GO:0006111 ! regulation of gluconeogenesis
is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006094 ! gluconeogenesis
relationship: negatively_regulates GO:0006094 ! gluconeogenesis

[Term]
id: GO:0045722
name: positive regulation of gluconeogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of gluconeogenesis." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of gluconeogenesis" NARROW []
synonym: "stimulation of gluconeogenesis" NARROW []
synonym: "up regulation of gluconeogenesis" EXACT []
synonym: "up-regulation of gluconeogenesis" EXACT []
synonym: "upregulation of gluconeogenesis" EXACT []
is_a: GO:0006111 ! regulation of gluconeogenesis
is_a: GO:0010907 ! positive regulation of glucose metabolic process
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006094 ! gluconeogenesis
relationship: positively_regulates GO:0006094 ! gluconeogenesis

[Term]
id: GO:0045723
name: positive regulation of fatty acid biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of fatty acid biosynthetic process" NARROW []
synonym: "positive regulation of fatty acid anabolism" EXACT []
synonym: "positive regulation of fatty acid biosynthesis" EXACT []
synonym: "positive regulation of fatty acid formation" EXACT []
synonym: "positive regulation of fatty acid synthesis" EXACT []
synonym: "stimulation of fatty acid biosynthetic process" NARROW []
synonym: "up regulation of fatty acid biosynthetic process" EXACT []
synonym: "up-regulation of fatty acid biosynthetic process" EXACT []
synonym: "upregulation of fatty acid biosynthetic process" EXACT []
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0042304 ! regulation of fatty acid biosynthetic process
is_a: GO:0045923 ! positive regulation of fatty acid metabolic process
is_a: GO:0046889 ! positive regulation of lipid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006633 ! fatty acid biosynthetic process
relationship: positively_regulates GO:0006633 ! fatty acid biosynthetic process

[Term]
id: GO:0045724
name: positive regulation of cilium assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the formation of a cilium." [GOC:go_curators]
synonym: "activation of cilium assembly" NARROW []
synonym: "positive regulation of flagellum assembly" BROAD []
synonym: "positive regulation of flagellum biogenesis" RELATED [GOC:mah]
synonym: "stimulation of cilium assembly" NARROW []
synonym: "up regulation of cilium assembly" EXACT []
synonym: "up-regulation of cilium assembly" EXACT []
synonym: "upregulation of cilium assembly" EXACT []
is_a: GO:0031346 ! positive regulation of cell projection organization
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:1902017 ! regulation of cilium assembly
is_a: GO:1902117 ! positive regulation of organelle assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042384 ! cilium assembly
relationship: positively_regulates GO:0042384 ! cilium assembly

[Term]
id: GO:0045725
name: positive regulation of glycogen biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of glycogen biosynthetic process" NARROW []
synonym: "positive regulation of glycogen anabolism" EXACT []
synonym: "positive regulation of glycogen biosynthesis" EXACT []
synonym: "positive regulation of glycogen formation" EXACT []
synonym: "positive regulation of glycogen synthesis" EXACT []
synonym: "stimulation of glycogen biosynthetic process" NARROW []
synonym: "up regulation of glycogen biosynthetic process" EXACT []
synonym: "up-regulation of glycogen biosynthetic process" EXACT []
synonym: "upregulation of glycogen biosynthetic process" EXACT []
is_a: GO:0005979 ! regulation of glycogen biosynthetic process
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0070875 ! positive regulation of glycogen metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0005978 ! glycogen biosynthetic process
relationship: positively_regulates GO:0005978 ! glycogen biosynthetic process

[Term]
id: GO:0045726
name: positive regulation of integrin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins." [GOC:go_curators]
synonym: "activation of integrin biosynthetic process" NARROW []
synonym: "positive regulation of integrin anabolism" EXACT []
synonym: "positive regulation of integrin biosynthesis" EXACT []
synonym: "positive regulation of integrin formation" EXACT []
synonym: "positive regulation of integrin synthesis" EXACT []
synonym: "stimulation of integrin biosynthetic process" NARROW []
synonym: "up regulation of integrin biosynthetic process" EXACT []
synonym: "up-regulation of integrin biosynthetic process" EXACT []
synonym: "upregulation of integrin biosynthetic process" EXACT []
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0045113 ! regulation of integrin biosynthetic process
is_a: GO:0051130 ! positive regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045112 ! integrin biosynthetic process
relationship: positively_regulates GO:0045112 ! integrin biosynthetic process

[Term]
id: GO:0045727
name: positive regulation of translation
namespace: biological_process
alt_id: GO:0045946
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:dph, GOC:go_curators, GOC:tb]
subset: gosubset_prok
synonym: "activation of protein biosynthetic process" NARROW []
synonym: "positive regulation of protein anabolism" EXACT []
synonym: "positive regulation of protein biosynthesis" EXACT []
synonym: "positive regulation of protein biosynthetic process" EXACT [GOC:tb]
synonym: "positive regulation of protein formation" EXACT []
synonym: "positive regulation of protein synthesis" EXACT []
synonym: "stimulation of protein biosynthetic process" NARROW []
synonym: "up regulation of protein biosynthetic process" EXACT []
synonym: "up-regulation of protein biosynthetic process" EXACT []
synonym: "upregulation of protein biosynthetic process" EXACT []
xref: Reactome:REACT_6236 "Activated DTOR phosphorylates DS6K, Drosophila melanogaster"
is_a: GO:0006417 ! regulation of translation
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0010628 ! positive regulation of gene expression
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0032270 ! positive regulation of cellular protein metabolic process
is_a: GO:0034250 ! positive regulation of cellular amide metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006412 ! translation
relationship: positively_regulates GO:0006412 ! translation

[Term]
id: GO:0045728
name: respiratory burst after phagocytosis
namespace: biological_process
def: "A phase of elevated metabolic activity, during which oxygen consumption increases, that occurs in neutrophils, monocytes, and macrophages shortly after phagocytosing material. An enhanced uptake of oxygen leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, which play a part in microbiocidal activity." [GOC:curators, ISBN:0198506732]
synonym: "metabolic burst after phagocytosis" EXACT []
synonym: "oxidative burst after phagocytosis" EXACT []
is_a: GO:0002679 ! respiratory burst involved in defense response

[Term]
id: GO:0045729
name: respiratory burst at fertilization
namespace: biological_process
def: "The phase of elevated metabolic activity, during which oxygen consumption increases, that occurs at fertilization. An enhanced uptake of oxygen leads to the production of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. Capacitation, a necessary prerequisite event to successful fertilization, can be induced by reactive oxygen species in vitro; hydrogen peroxide is used as an extracellular oxidant to cross-link the protective surface envelopes." [ISBN:0198506732, PMID:2537493, PMID:9013127]
synonym: "metabolic burst at fertilization" EXACT []
synonym: "oxidative burst at fertilization" EXACT []
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0045730 ! respiratory burst
intersection_of: GO:0045730 ! respiratory burst
intersection_of: part_of GO:0009566 ! fertilization
relationship: part_of GO:0007338 ! single fertilization
relationship: part_of GO:0009566 ! fertilization

[Term]
id: GO:0045730
name: respiratory burst
namespace: biological_process
def: "A phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [ISBN:0198506732]
synonym: "metabolic burst" EXACT []
synonym: "oxidative burst" EXACT []
xref: Wikipedia:Respiratory_burst
is_a: GO:0044710 ! single-organism metabolic process

[Term]
id: GO:0045732
name: positive regulation of protein catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of protein catabolic process" NARROW []
synonym: "positive regulation of protein breakdown" EXACT []
synonym: "positive regulation of protein catabolism" EXACT []
synonym: "positive regulation of protein degradation" EXACT []
synonym: "stimulation of protein catabolic process" NARROW []
synonym: "up regulation of protein catabolic process" EXACT []
synonym: "up-regulation of protein catabolic process" EXACT []
synonym: "upregulation of protein catabolic process" EXACT []
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0042176 ! regulation of protein catabolic process
is_a: GO:0051247 ! positive regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030163 ! protein catabolic process
relationship: positively_regulates GO:0030163 ! protein catabolic process

[Term]
id: GO:0045733
name: acetate catabolic process
namespace: biological_process
alt_id: GO:0019663
def: "The chemical reactions and pathways resulting in the breakdown of acetate, the anion of acetic acid." [CHEBI:30089, GOC:go_curators]
subset: gosubset_prok
synonym: "acetate breakdown" EXACT []
synonym: "acetate catabolism" EXACT []
synonym: "acetate degradation" EXACT []
synonym: "homoacetate catabolic process" RELATED []
is_a: GO:0006083 ! acetate metabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0045734
name: regulation of acetate catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate, the anion of acetic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of acetate breakdown" EXACT []
synonym: "regulation of acetate catabolism" EXACT []
synonym: "regulation of acetate degradation" EXACT []
is_a: GO:0010565 ! regulation of cellular ketone metabolic process
is_a: GO:0031329 ! regulation of cellular catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045733 ! acetate catabolic process
relationship: regulates GO:0045733 ! acetate catabolic process

[Term]
id: GO:0045735
name: nutrient reservoir activity
namespace: molecular_function
def: "Functions in the storage of nutritious substrates." [GOC:ai]
comment: Note that this term can be used in place of the obsolete terms 'storage protein ; GO:0005187' and 'storage protein of fat body (sensu Insecta) ; GO:0008041'.
subset: goslim_pir
subset: gosubset_prok
synonym: "storage protein" RELATED []
synonym: "storage protein of fat body" RELATED []
synonym: "yolk protein" RELATED []
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0045736
name: negative regulation of cyclin-dependent protein serine/threonine kinase activity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity." [GOC:go_curators, GOC:pr]
synonym: "CDK inhibitor" RELATED []
synonym: "cyclin-dependent kinase inhibitor" RELATED []
synonym: "down regulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "down-regulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "downregulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "inhibition of cyclin-dependent protein kinase activity" NARROW []
synonym: "negative regulation of CDK activity" EXACT []
synonym: "negative regulation of cyclin-dependent protein kinase activity" BROAD []
is_a: GO:0000079 ! regulation of cyclin-dependent protein serine/threonine kinase activity
is_a: GO:0045786 ! negative regulation of cell cycle
is_a: GO:0071901 ! negative regulation of protein serine/threonine kinase activity
is_a: GO:1904030 ! negative regulation of cyclin-dependent protein kinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004693 ! cyclin-dependent protein serine/threonine kinase activity
relationship: negatively_regulates GO:0004693 ! cyclin-dependent protein serine/threonine kinase activity

[Term]
id: GO:0045737
name: positive regulation of cyclin-dependent protein serine/threonine kinase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of CDK activity." [GOC:go_curators, GOC:pr]
synonym: "activation of cyclin-dependent protein kinase activity" NARROW []
synonym: "positive regulation of CDK activity" EXACT []
synonym: "positive regulation of cyclin-dependent protein kinase activity" BROAD [GOC:pr]
synonym: "stimulation of cyclin-dependent protein kinase activity" NARROW []
synonym: "up regulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "up-regulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "upregulation of cyclin-dependent protein kinase activity" EXACT []
is_a: GO:0000079 ! regulation of cyclin-dependent protein serine/threonine kinase activity
is_a: GO:0045787 ! positive regulation of cell cycle
is_a: GO:0071902 ! positive regulation of protein serine/threonine kinase activity
is_a: GO:1904031 ! positive regulation of cyclin-dependent protein kinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004693 ! cyclin-dependent protein serine/threonine kinase activity
relationship: positively_regulates GO:0004693 ! cyclin-dependent protein serine/threonine kinase activity

[Term]
id: GO:0045738
name: negative regulation of DNA repair
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA repair." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of DNA repair" EXACT []
synonym: "down-regulation of DNA repair" EXACT []
synonym: "downregulation of DNA repair" EXACT []
synonym: "inhibition of DNA repair" NARROW []
is_a: GO:0006282 ! regulation of DNA repair
is_a: GO:0051053 ! negative regulation of DNA metabolic process
is_a: GO:2001021 ! negative regulation of response to DNA damage stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006281 ! DNA repair
relationship: negatively_regulates GO:0006281 ! DNA repair

[Term]
id: GO:0045739
name: positive regulation of DNA repair
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA repair." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of DNA repair" NARROW []
synonym: "stimulation of DNA repair" NARROW []
synonym: "up regulation of DNA repair" EXACT []
synonym: "up-regulation of DNA repair" EXACT []
synonym: "upregulation of DNA repair" EXACT []
is_a: GO:0006282 ! regulation of DNA repair
is_a: GO:0051054 ! positive regulation of DNA metabolic process
is_a: GO:2001022 ! positive regulation of response to DNA damage stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006281 ! DNA repair
relationship: positively_regulates GO:0006281 ! DNA repair

[Term]
id: GO:0045740
name: positive regulation of DNA replication
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA replication." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of DNA replication" NARROW []
synonym: "stimulation of DNA replication" NARROW []
synonym: "up regulation of DNA replication" EXACT []
synonym: "up-regulation of DNA replication" EXACT []
synonym: "upregulation of DNA replication" EXACT []
is_a: GO:0006275 ! regulation of DNA replication
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0051054 ! positive regulation of DNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006260 ! DNA replication
relationship: positively_regulates GO:0006260 ! DNA replication

[Term]
id: GO:0045741
name: positive regulation of epidermal growth factor-activated receptor activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of EGF-activated receptor activity." [GOC:go_curators]
synonym: "activation of epidermal growth factor receptor activity" NARROW []
synonym: "positive regulation of EGF receptor activity" EXACT []
synonym: "positive regulation of EGFR activity" EXACT []
synonym: "positive regulation of epidermal growth factor receptor activity" EXACT [GOC:bf, GOC:signaling]
synonym: "stimulation of epidermal growth factor receptor activity" NARROW []
synonym: "up regulation of epidermal growth factor receptor activity" EXACT []
synonym: "up-regulation of epidermal growth factor receptor activity" EXACT []
synonym: "upregulation of epidermal growth factor receptor activity" EXACT []
is_a: GO:0007176 ! regulation of epidermal growth factor-activated receptor activity
is_a: GO:0045742 ! positive regulation of epidermal growth factor receptor signaling pathway
is_a: GO:0061098 ! positive regulation of protein tyrosine kinase activity
is_a: GO:2000273 ! positive regulation of receptor activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0005006 ! epidermal growth factor-activated receptor activity
relationship: positively_regulates GO:0005006 ! epidermal growth factor-activated receptor activity

[Term]
id: GO:0045742
name: positive regulation of epidermal growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators]
synonym: "activation of epidermal growth factor receptor signaling pathway" NARROW []
synonym: "positive regulation of EGF receptor signaling pathway" EXACT []
synonym: "positive regulation of EGF receptor signalling pathway" EXACT []
synonym: "positive regulation of EGFR signaling pathway" EXACT []
synonym: "stimulation of epidermal growth factor receptor signaling pathway" NARROW []
synonym: "up regulation of epidermal growth factor receptor signaling pathway" EXACT []
synonym: "up-regulation of epidermal growth factor receptor signaling pathway" EXACT []
synonym: "upregulation of epidermal growth factor receptor signaling pathway" EXACT []
is_a: GO:0042058 ! regulation of epidermal growth factor receptor signaling pathway
is_a: GO:1901186 ! positive regulation of ERBB signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007173 ! epidermal growth factor receptor signaling pathway
relationship: positively_regulates GO:0007173 ! epidermal growth factor receptor signaling pathway

[Term]
id: GO:0045743
name: positive regulation of fibroblast growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity." [GOC:go_curators]
synonym: "activation of fibroblast growth factor receptor signaling pathway" NARROW []
synonym: "positive regulation of FGF receptor signaling pathway" EXACT []
synonym: "positive regulation of FGF receptor signalling pathway" EXACT []
synonym: "positive regulation of FGFR signaling pathway" EXACT []
synonym: "stimulation of fibroblast growth factor receptor signaling pathway" NARROW []
synonym: "up regulation of fibroblast growth factor receptor signaling pathway" EXACT []
synonym: "up-regulation of fibroblast growth factor receptor signaling pathway" EXACT []
synonym: "upregulation of fibroblast growth factor receptor signaling pathway" EXACT []
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0040036 ! regulation of fibroblast growth factor receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008543 ! fibroblast growth factor receptor signaling pathway
relationship: positively_regulates GO:0008543 ! fibroblast growth factor receptor signaling pathway

[Term]
id: GO:0045744
name: negative regulation of G-protein coupled receptor protein signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity." [GOC:go_curators]
synonym: "down regulation of G-protein coupled receptor protein signaling pathway" EXACT []
synonym: "down-regulation of G-protein coupled receptor protein signaling pathway" EXACT []
synonym: "downregulation of G-protein coupled receptor protein signaling pathway" EXACT []
synonym: "inhibition of G-protein coupled receptor protein signaling pathway" NARROW []
synonym: "negative regulation of G protein coupled receptor protein signaling pathway" EXACT []
synonym: "negative regulation of G protein coupled receptor protein signalling pathway" EXACT []
synonym: "negative regulation of G-protein coupled receptor protein signalling pathway" EXACT []
synonym: "negative regulation of G-protein-coupled receptor protein signaling pathway" EXACT []
synonym: "negative regulation of G-protein-coupled receptor protein signalling pathway" EXACT []
synonym: "negative regulation of GPCR protein signaling pathway" EXACT []
synonym: "negative regulation of GPCR protein signalling pathway" EXACT []
is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:0009968 ! negative regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007186 ! G-protein coupled receptor signaling pathway
relationship: negatively_regulates GO:0007186 ! G-protein coupled receptor signaling pathway

[Term]
id: GO:0045745
name: positive regulation of G-protein coupled receptor protein signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity." [GOC:go_curators]
synonym: "activation of G-protein coupled receptor protein signaling pathway" NARROW []
synonym: "positive regulation of G protein coupled receptor protein signaling pathway" EXACT []
synonym: "positive regulation of G protein coupled receptor protein signalling pathway" EXACT []
synonym: "positive regulation of G-protein coupled receptor protein signalling pathway" EXACT []
synonym: "positive regulation of G-protein-coupled receptor protein signaling pathway" EXACT []
synonym: "positive regulation of G-protein-coupled receptor protein signalling pathway" EXACT []
synonym: "positive regulation of GPCR protein signaling pathway" EXACT []
synonym: "positive regulation of GPCR protein signalling pathway" EXACT []
synonym: "stimulation of G-protein coupled receptor protein signaling pathway" NARROW []
synonym: "up regulation of G-protein coupled receptor protein signaling pathway" EXACT []
synonym: "up-regulation of G-protein coupled receptor protein signaling pathway" EXACT []
synonym: "upregulation of G-protein coupled receptor protein signaling pathway" EXACT []
is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:0009967 ! positive regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007186 ! G-protein coupled receptor signaling pathway
relationship: positively_regulates GO:0007186 ! G-protein coupled receptor signaling pathway

[Term]
id: GO:0045746
name: negative regulation of Notch signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]
synonym: "down regulation of Notch signaling pathway" EXACT []
synonym: "down-regulation of Notch signaling pathway" EXACT []
synonym: "downregulation of Notch signaling pathway" EXACT []
synonym: "inhibition of Notch signaling pathway" NARROW []
synonym: "negative regulation of N signaling pathway" EXACT []
synonym: "negative regulation of N signalling pathway" EXACT []
synonym: "negative regulation of Notch signalling pathway" EXACT []
is_a: GO:0008593 ! regulation of Notch signaling pathway
is_a: GO:0009968 ! negative regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007219 ! Notch signaling pathway
relationship: negatively_regulates GO:0007219 ! Notch signaling pathway

[Term]
id: GO:0045747
name: positive regulation of Notch signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]
synonym: "activation of Notch signaling pathway" NARROW []
synonym: "positive regulation of N signaling pathway" EXACT []
synonym: "positive regulation of N signalling pathway" EXACT []
synonym: "positive regulation of Notch signalling pathway" EXACT []
synonym: "stimulation of Notch signaling pathway" NARROW []
synonym: "up regulation of Notch signaling pathway" EXACT []
synonym: "up-regulation of Notch signaling pathway" EXACT []
synonym: "upregulation of Notch signaling pathway" EXACT []
is_a: GO:0008593 ! regulation of Notch signaling pathway
is_a: GO:0009967 ! positive regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007219 ! Notch signaling pathway
relationship: positively_regulates GO:0007219 ! Notch signaling pathway

[Term]
id: GO:0045748
name: positive regulation of R8 cell spacing in compound eye
namespace: biological_process
def: "Any process that activates or enforces the correct R8 cell spacing in a compound eye." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "activation of R8 spacing" NARROW []
synonym: "positive regulation of R8 spacing" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of R8 spacing" NARROW []
synonym: "up regulation of R8 spacing" EXACT []
synonym: "up-regulation of R8 spacing" EXACT []
synonym: "upregulation of R8 spacing" EXACT []
is_a: GO:0045468 ! regulation of R8 cell spacing in compound eye

[Term]
id: GO:0045749
name: obsolete negative regulation of S phase of mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of S phase of mitotic cell cycle activity." [GOC:go_curators]
comment: This term was made obsolete as part of the cell cycle overhaul. This is because it was decided that cell cycle phases are intervals and so cannot be regulated, rather it is the transitions between the phases that are regulated.
synonym: "down regulation of S phase of mitotic cell cycle" EXACT []
synonym: "down-regulation of S phase of mitotic cell cycle" EXACT []
synonym: "downregulation of S phase of mitotic cell cycle" EXACT []
synonym: "inhibition of S phase of mitotic cell cycle" NARROW []
synonym: "negative regulation of S phase of mitotic cell cycle" EXACT []
synonym: "negative regulation of S-phase of mitotic cell cycle" EXACT []
is_obsolete: true

[Term]
id: GO:0045750
name: obsolete positive regulation of S phase of mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of S phase of mitotic cell cycle activity." [GOC:go_curators]
comment: This term was made obsolete as part of the cell cycle overhaul. This is because it was decided that cell cycle phases are intervals and so cannot be regulated, rather it is the transitions between the phases that are regulated.
synonym: "activation of S phase of mitotic cell cycle" NARROW []
synonym: "positive regulation of S phase of mitotic cell cycle" EXACT []
synonym: "positive regulation of S-phase of mitotic cell cycle" EXACT []
synonym: "stimulation of S phase of mitotic cell cycle" NARROW []
synonym: "up regulation of S phase of mitotic cell cycle" EXACT []
synonym: "up-regulation of S phase of mitotic cell cycle" EXACT []
synonym: "upregulation of S phase of mitotic cell cycle" EXACT []
is_obsolete: true

[Term]
id: GO:0045751
name: negative regulation of Toll signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the Tl signaling pathway." [GOC:go_curators]
synonym: "down regulation of Toll signaling pathway" EXACT []
synonym: "down-regulation of Toll signaling pathway" EXACT []
synonym: "downregulation of Toll signaling pathway" EXACT []
synonym: "inhibition of Toll signaling pathway" NARROW []
synonym: "negative regulation of Tl signaling pathway" EXACT []
synonym: "negative regulation of Tl signalling pathway" EXACT []
is_a: GO:0008592 ! regulation of Toll signaling pathway
is_a: GO:0009968 ! negative regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008063 ! Toll signaling pathway
relationship: negatively_regulates GO:0008063 ! Toll signaling pathway

[Term]
id: GO:0045752
name: positive regulation of Toll signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the Tl signaling pathway." [GOC:go_curators]
synonym: "activation of Toll signaling pathway" NARROW []
synonym: "positive regulation of Tl signaling pathway" EXACT []
synonym: "positive regulation of Tl signalling pathway" EXACT []
synonym: "stimulation of Toll signaling pathway" NARROW []
synonym: "up regulation of Toll signaling pathway" EXACT []
synonym: "up-regulation of Toll signaling pathway" EXACT []
synonym: "upregulation of Toll signaling pathway" EXACT []
is_a: GO:0008592 ! regulation of Toll signaling pathway
is_a: GO:0009967 ! positive regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008063 ! Toll signaling pathway
relationship: positively_regulates GO:0008063 ! Toll signaling pathway

[Term]
id: GO:0045753
name: negative regulation of acetate catabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of acetate catabolic process" EXACT []
synonym: "down-regulation of acetate catabolic process" EXACT []
synonym: "downregulation of acetate catabolic process" EXACT []
synonym: "inhibition of acetate catabolic process" NARROW []
synonym: "negative regulation of acetate breakdown" EXACT []
synonym: "negative regulation of acetate catabolism" EXACT []
synonym: "negative regulation of acetate degradation" EXACT []
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:0045734 ! regulation of acetate catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045733 ! acetate catabolic process
relationship: negatively_regulates GO:0045733 ! acetate catabolic process

[Term]
id: GO:0045754
name: positive regulation of acetate catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of acetate catabolic process" NARROW []
synonym: "positive regulation of acetate breakdown" EXACT []
synonym: "positive regulation of acetate catabolism" EXACT []
synonym: "positive regulation of acetate degradation" EXACT []
synonym: "stimulation of acetate catabolic process" NARROW []
synonym: "up regulation of acetate catabolic process" EXACT []
synonym: "up-regulation of acetate catabolic process" EXACT []
synonym: "upregulation of acetate catabolic process" EXACT []
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:0045734 ! regulation of acetate catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045733 ! acetate catabolic process
relationship: positively_regulates GO:0045733 ! acetate catabolic process

[Term]
id: GO:0045755
name: negative regulation of initiation of acetate catabolic process by acetate
namespace: biological_process
def: "Any process that stops or prevents the activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of initiation of acetate catabolic process by acetate" EXACT []
synonym: "down-regulation of initiation of acetate catabolic process by acetate" EXACT []
synonym: "downregulation of initiation of acetate catabolic process by acetate" EXACT []
synonym: "inhibition of initiation of acetate catabolic process by acetate" NARROW []
synonym: "negative regulation of initiation of acetate breakdown by acetate" EXACT []
synonym: "negative regulation of initiation of acetate degradation by acetate" EXACT []
is_a: GO:0045147 ! regulation of initiation of acetate catabolic process by acetate
is_a: GO:1901458 ! negative regulation of response to acetate
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045146 ! initiation of acetate catabolic process by acetate
relationship: negatively_regulates GO:0045146 ! initiation of acetate catabolic process by acetate

[Term]
id: GO:0045756
name: positive regulation of initiation of acetate catabolic process by acetate
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of initiation of acetate catabolic process by acetate" NARROW []
synonym: "positive regulation of initiation of acetate breakdown by acetate" EXACT []
synonym: "positive regulation of initiation of acetate degradation by acetate" EXACT []
synonym: "stimulation of initiation of acetate catabolic process by acetate" NARROW []
synonym: "up regulation of initiation of acetate catabolic process by acetate" EXACT []
synonym: "up-regulation of initiation of acetate catabolic process by acetate" EXACT []
synonym: "upregulation of initiation of acetate catabolic process by acetate" EXACT []
is_a: GO:0045147 ! regulation of initiation of acetate catabolic process by acetate
is_a: GO:1901459 ! positive regulation of response to acetate
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045146 ! initiation of acetate catabolic process by acetate
relationship: positively_regulates GO:0045146 ! initiation of acetate catabolic process by acetate

[Term]
id: GO:0045757
name: obsolete negative regulation of actin polymerization and/or depolymerization
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization and/or depolymerization." [GOC:go_curators]
comment: This term was made obsolete because it has been split.
synonym: "negative regulation of actin polymerization and/or depolymerization" EXACT []
is_obsolete: true
consider: GO:0030835
consider: GO:0030837

[Term]
id: GO:0045758
name: obsolete positive regulation of actin polymerization and/or depolymerization
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of actin polymerization and/or depolymerization." [GOC:go_curators]
comment: This term was made obsolete because it has been split.
synonym: "positive regulation of actin polymerization and/or depolymerization" EXACT []
is_obsolete: true
consider: GO:0030836
consider: GO:0030838

[Term]
id: GO:0045759
name: negative regulation of action potential
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:go_curators]
synonym: "down regulation of action potential" EXACT []
synonym: "down-regulation of action potential" EXACT []
synonym: "downregulation of action potential" EXACT []
synonym: "inhibition of action potential" NARROW []
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0098900 ! regulation of action potential
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0001508 ! action potential
relationship: negatively_regulates GO:0001508 ! action potential

[Term]
id: GO:0045760
name: positive regulation of action potential
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:go_curators]
synonym: "activation of action potential" NARROW []
synonym: "stimulation of action potential" NARROW []
synonym: "up regulation of action potential" EXACT []
synonym: "up-regulation of action potential" EXACT []
synonym: "upregulation of action potential" EXACT []
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:0098900 ! regulation of action potential
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:0001508 ! action potential
relationship: positively_regulates GO:0001508 ! action potential

[Term]
id: GO:0045761
name: regulation of adenylate cyclase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of adenylate cyclase activity." [GOC:go_curators]
synonym: "adenylate cyclase regulator" RELATED []
synonym: "regulation of adenylyl cyclase activity" EXACT []
is_a: GO:0030817 ! regulation of cAMP biosynthetic process
is_a: GO:0031279 ! regulation of cyclase activity
is_a: GO:0051339 ! regulation of lyase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004016 ! adenylate cyclase activity
relationship: regulates GO:0004016 ! adenylate cyclase activity

[Term]
id: GO:0045762
name: positive regulation of adenylate cyclase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of adenylate cyclase activity." [GOC:go_curators]
synonym: "adenylate cyclase activator" RELATED []
synonym: "positive regulation of adenylyl cyclase activity" EXACT []
synonym: "stimulation of adenylate cyclase activity" NARROW []
synonym: "up regulation of adenylate cyclase activity" EXACT []
synonym: "up-regulation of adenylate cyclase activity" EXACT []
synonym: "upregulation of adenylate cyclase activity" EXACT []
is_a: GO:0030819 ! positive regulation of cAMP biosynthetic process
is_a: GO:0031281 ! positive regulation of cyclase activity
is_a: GO:0045761 ! regulation of adenylate cyclase activity
is_a: GO:0051349 ! positive regulation of lyase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004016 ! adenylate cyclase activity
relationship: positively_regulates GO:0004016 ! adenylate cyclase activity

[Term]
id: GO:0045763
name: negative regulation of cellular amino acid metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amino acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of amino acid metabolic process" EXACT []
synonym: "down-regulation of amino acid metabolic process" EXACT []
synonym: "downregulation of amino acid metabolic process" EXACT []
synonym: "inhibition of amino acid metabolic process" NARROW []
synonym: "negative regulation of amino acid metabolism" EXACT []
is_a: GO:0006521 ! regulation of cellular amino acid metabolic process
is_a: GO:0033239 ! negative regulation of cellular amine metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006520 ! cellular amino acid metabolic process
relationship: negatively_regulates GO:0006520 ! cellular amino acid metabolic process

[Term]
id: GO:0045764
name: positive regulation of cellular amino acid metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amino acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of amino acid metabolic process" NARROW []
synonym: "positive regulation of amino acid metabolism" EXACT []
synonym: "stimulation of amino acid metabolic process" NARROW []
synonym: "up regulation of amino acid metabolic process" EXACT []
synonym: "up-regulation of amino acid metabolic process" EXACT []
synonym: "upregulation of amino acid metabolic process" EXACT []
is_a: GO:0006521 ! regulation of cellular amino acid metabolic process
is_a: GO:0033240 ! positive regulation of cellular amine metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006520 ! cellular amino acid metabolic process
relationship: positively_regulates GO:0006520 ! cellular amino acid metabolic process

[Term]
id: GO:0045765
name: regulation of angiogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of angiogenesis." [GOC:go_curators]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:1901342 ! regulation of vasculature development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001525 ! angiogenesis
relationship: regulates GO:0001525 ! angiogenesis

[Term]
id: GO:0045766
name: positive regulation of angiogenesis
namespace: biological_process
def: "Any process that activates or increases angiogenesis." [GOC:go_curators]
synonym: "activation of angiogenesis" NARROW []
synonym: "stimulation of angiogenesis" NARROW []
synonym: "up regulation of angiogenesis" EXACT []
synonym: "up-regulation of angiogenesis" EXACT []
synonym: "upregulation of angiogenesis" EXACT []
is_a: GO:0045765 ! regulation of angiogenesis
is_a: GO:1904018 ! positive regulation of vasculature development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001525 ! angiogenesis
relationship: positively_regulates GO:0001525 ! angiogenesis

[Term]
id: GO:0045767
name: obsolete regulation of anti-apoptosis
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of anti-apoptosis." [GOC:go_curators, GOC:mtg_apoptosis]
comment: This term was made obsolete because it was ill-defined.
synonym: "regulation of anti-apoptosis" EXACT []
is_obsolete: true

[Term]
id: GO:0045768
name: obsolete positive regulation of anti-apoptosis
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of anti-apoptosis." [GOC:go_curators, GOC:mtg_apoptosis]
comment: This term was made obsolete because it was ill-defined.
synonym: "activation of anti-apoptosis" NARROW []
synonym: "positive regulation of anti-apoptosis" EXACT []
synonym: "stimulation of anti-apoptosis" NARROW []
synonym: "up regulation of anti-apoptosis" EXACT []
synonym: "up-regulation of anti-apoptosis" EXACT []
synonym: "upregulation of anti-apoptosis" EXACT []
is_obsolete: true

[Term]
id: GO:0045769
name: negative regulation of asymmetric cell division
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of asymmetric cell division." [GOC:go_curators]
synonym: "down regulation of asymmetric cell division" EXACT []
synonym: "down-regulation of asymmetric cell division" EXACT []
synonym: "downregulation of asymmetric cell division" EXACT []
synonym: "inhibition of asymmetric cell division" NARROW []
is_a: GO:0009786 ! regulation of asymmetric cell division
is_a: GO:0051782 ! negative regulation of cell division
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008356 ! asymmetric cell division
relationship: negatively_regulates GO:0008356 ! asymmetric cell division

[Term]
id: GO:0045770
name: positive regulation of asymmetric cell division
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of asymmetric cell division." [GOC:go_curators]
synonym: "activation of asymmetric cell division" NARROW []
synonym: "stimulation of asymmetric cell division" NARROW []
synonym: "up regulation of asymmetric cell division" EXACT []
synonym: "up-regulation of asymmetric cell division" EXACT []
synonym: "upregulation of asymmetric cell division" EXACT []
is_a: GO:0009786 ! regulation of asymmetric cell division
is_a: GO:0051781 ! positive regulation of cell division
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008356 ! asymmetric cell division
relationship: positively_regulates GO:0008356 ! asymmetric cell division

[Term]
id: GO:0045771
name: negative regulation of autophagosome size
namespace: biological_process
def: "Any process that reduces autophagosome size." [GOC:autophagy, GOC:go_curators]
synonym: "down regulation of autophagic vacuole size" EXACT []
synonym: "down-regulation of autophagic vacuole size" EXACT []
synonym: "downregulation of autophagic vacuole size" EXACT []
synonym: "inhibition of autophagic vacuole size" NARROW []
synonym: "negative regulation of autophagic vacuole size" EXACT [GOC:autophagy]
is_a: GO:0016243 ! regulation of autophagosome size

[Term]
id: GO:0045772
name: positive regulation of autophagosome size
namespace: biological_process
def: "Any process that increases autophagosome size." [GOC:autophagy, GOC:go_curators]
synonym: "activation of autophagic vacuole size" NARROW []
synonym: "positive regulation of autophagic vacuole size" EXACT [GOC:autophagy]
synonym: "stimulation of autophagic vacuole size" NARROW []
synonym: "up regulation of autophagic vacuole size" EXACT []
synonym: "up-regulation of autophagic vacuole size" EXACT []
synonym: "upregulation of autophagic vacuole size" EXACT []
is_a: GO:0016243 ! regulation of autophagosome size

[Term]
id: GO:0045773
name: positive regulation of axon extension
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of axon extension." [GOC:go_curators]
synonym: "activation of axon extension" NARROW []
synonym: "stimulation of axon extension" NARROW []
synonym: "up regulation of axon extension" EXACT []
synonym: "up-regulation of axon extension" EXACT []
synonym: "upregulation of axon extension" EXACT []
is_a: GO:0030307 ! positive regulation of cell growth
is_a: GO:0030516 ! regulation of axon extension
is_a: GO:0048639 ! positive regulation of developmental growth
is_a: GO:0050772 ! positive regulation of axonogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048675 ! axon extension
relationship: positively_regulates GO:0048675 ! axon extension

[Term]
id: GO:0045774
name: negative regulation of beta 2 integrin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta 2 integrins." [GOC:go_curators]
synonym: "down regulation of beta 2 integrin biosynthetic process" EXACT []
synonym: "down-regulation of beta 2 integrin biosynthetic process" EXACT []
synonym: "downregulation of beta 2 integrin biosynthetic process" EXACT []
synonym: "inhibition of beta 2 integrin biosynthetic process" NARROW []
synonym: "negative regulation of beta 2 integrin anabolism" EXACT []
synonym: "negative regulation of beta 2 integrin biosynthesis" EXACT []
synonym: "negative regulation of beta 2 integrin formation" EXACT []
synonym: "negative regulation of beta 2 integrin synthesis" EXACT []
is_a: GO:0045115 ! regulation of beta 2 integrin biosynthetic process
is_a: GO:0045720 ! negative regulation of integrin biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045114 ! beta 2 integrin biosynthetic process
relationship: negatively_regulates GO:0045114 ! beta 2 integrin biosynthetic process

[Term]
id: GO:0045775
name: positive regulation of beta 2 integrin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta 2 integrins." [GOC:go_curators]
synonym: "activation of beta 2 integrin biosynthetic process" NARROW []
synonym: "positive regulation of beta 2 integrin anabolism" EXACT []
synonym: "positive regulation of beta 2 integrin biosynthesis" EXACT []
synonym: "positive regulation of beta 2 integrin formation" EXACT []
synonym: "positive regulation of beta 2 integrin synthesis" EXACT []
synonym: "stimulation of beta 2 integrin biosynthetic process" NARROW []
synonym: "up regulation of beta 2 integrin biosynthetic process" EXACT []
synonym: "up-regulation of beta 2 integrin biosynthetic process" EXACT []
synonym: "upregulation of beta 2 integrin biosynthetic process" EXACT []
is_a: GO:0045115 ! regulation of beta 2 integrin biosynthetic process
is_a: GO:0045726 ! positive regulation of integrin biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045114 ! beta 2 integrin biosynthetic process
relationship: positively_regulates GO:0045114 ! beta 2 integrin biosynthetic process

[Term]
id: GO:0045776
name: negative regulation of blood pressure
namespace: biological_process
def: "Any process in which the force of blood traveling through the circulatory system is decreased." [GOC:go_curators, GOC:mtg_cardio]
synonym: "down regulation of blood pressure" EXACT []
synonym: "down-regulation of blood pressure" EXACT []
synonym: "downregulation of blood pressure" EXACT []
synonym: "inhibition of blood pressure" NARROW []
is_a: GO:0008217 ! regulation of blood pressure

[Term]
id: GO:0045777
name: positive regulation of blood pressure
namespace: biological_process
def: "Any process in which the force of blood traveling through the circulatory system is increased." [GOC:go_curators, GOC:mtg_cardio]
synonym: "activation of blood pressure" NARROW []
synonym: "stimulation of blood pressure" NARROW []
synonym: "up regulation of blood pressure" EXACT []
synonym: "up-regulation of blood pressure" EXACT []
synonym: "upregulation of blood pressure" EXACT []
is_a: GO:0008217 ! regulation of blood pressure

[Term]
id: GO:0045778
name: positive regulation of ossification
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of bone formation." [GOC:go_curators]
synonym: "activation of ossification" NARROW []
synonym: "positive regulation of bone biosynthesis" EXACT []
synonym: "positive regulation of bone formation" EXACT []
synonym: "stimulation of ossification" NARROW []
synonym: "up regulation of ossification" EXACT []
synonym: "up-regulation of ossification" EXACT []
synonym: "upregulation of ossification" EXACT []
is_a: GO:0030278 ! regulation of ossification
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001503 ! ossification
relationship: positively_regulates GO:0001503 ! ossification

[Term]
id: GO:0045779
name: negative regulation of bone resorption
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of bone resorption." [GOC:go_curators]
synonym: "down regulation of bone resorption" EXACT []
synonym: "down-regulation of bone resorption" EXACT []
synonym: "downregulation of bone resorption" EXACT []
synonym: "inhibition of bone resorption" NARROW []
is_a: GO:0032845 ! negative regulation of homeostatic process
is_a: GO:0045124 ! regulation of bone resorption
is_a: GO:0046851 ! negative regulation of bone remodeling
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045453 ! bone resorption
relationship: negatively_regulates GO:0045453 ! bone resorption

[Term]
id: GO:0045780
name: positive regulation of bone resorption
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of bone resorption." [GOC:go_curators]
synonym: "activation of bone resorption" NARROW []
synonym: "stimulation of bone resorption" NARROW []
synonym: "up regulation of bone resorption" EXACT []
synonym: "up-regulation of bone resorption" EXACT []
synonym: "upregulation of bone resorption" EXACT []
is_a: GO:0032846 ! positive regulation of homeostatic process
is_a: GO:0045124 ! regulation of bone resorption
is_a: GO:0046852 ! positive regulation of bone remodeling
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045453 ! bone resorption
relationship: positively_regulates GO:0045453 ! bone resorption

[Term]
id: GO:0045781
name: negative regulation of cell budding
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell budding." [GOC:go_curators]
synonym: "down regulation of cell budding" EXACT []
synonym: "down-regulation of cell budding" EXACT []
synonym: "downregulation of cell budding" EXACT []
synonym: "inhibition of cell budding" NARROW []
synonym: "negative regulation of budding" BROAD []
is_a: GO:0007116 ! regulation of cell budding
is_a: GO:0051782 ! negative regulation of cell division
is_a: GO:1903665 ! negative regulation of asexual reproduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007114 ! cell budding
relationship: negatively_regulates GO:0007114 ! cell budding

[Term]
id: GO:0045782
name: positive regulation of cell budding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell budding." [GOC:go_curators]
synonym: "activation of cell budding" NARROW []
synonym: "positive regulation of budding" BROAD []
synonym: "stimulation of cell budding" NARROW []
synonym: "up regulation of cell budding" EXACT []
synonym: "up-regulation of cell budding" EXACT []
synonym: "upregulation of cell budding" EXACT []
is_a: GO:0007116 ! regulation of cell budding
is_a: GO:0051781 ! positive regulation of cell division
is_a: GO:1903666 ! positive regulation of asexual reproduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007114 ! cell budding
relationship: positively_regulates GO:0007114 ! cell budding

[Term]
id: GO:0045783
name: obsolete negative regulation of calcium in ER
namespace: biological_process
def: "OBSOLETE. Any process that reduces the concentration of calcium in the ER." [GOC:go_curators]
comment: This term was made obsolete because the term name is ambiguous and as a result, the term was incorrectly placed in the ontology (it was a descendant of 'protein transport').
synonym: "negative regulation of calcium in ER" EXACT []
is_obsolete: true
consider: GO:0005783
consider: GO:0006874

[Term]
id: GO:0045784
name: obsolete positive regulation of calcium in ER
namespace: biological_process
def: "OBSOLETE. Any process that increases the concentration of calcium in the ER." [GOC:go_curators]
comment: This term was made obsolete because the term name is ambiguous and as a result, the term was incorrectly placed in the ontology (it was a descendant of 'protein transport').
synonym: "positive regulation of calcium in ER" EXACT []
is_obsolete: true
consider: GO:0005783
consider: GO:0006874

[Term]
id: GO:0045785
name: positive regulation of cell adhesion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell adhesion." [GOC:go_curators]
synonym: "activation of cell adhesion" NARROW []
synonym: "stimulation of cell adhesion" NARROW []
synonym: "up regulation of cell adhesion" EXACT []
synonym: "up-regulation of cell adhesion" EXACT []
synonym: "upregulation of cell adhesion" EXACT []
is_a: GO:0030155 ! regulation of cell adhesion
is_a: GO:0048522 ! positive regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007155 ! cell adhesion
relationship: positively_regulates GO:0007155 ! cell adhesion

[Term]
id: GO:0045786
name: negative regulation of cell cycle
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "down regulation of progression through cell cycle" EXACT []
synonym: "down-regulation of progression through cell cycle" EXACT []
synonym: "downregulation of progression through cell cycle" EXACT []
synonym: "inhibition of progression through cell cycle" NARROW []
synonym: "negative regulation of cell cycle progression" EXACT []
synonym: "negative regulation of progression through cell cycle" EXACT []
xref: Reactome:REACT_102454 "p75NTR negatively regulates cell cycle via SC1, Taeniopygia guttata"
xref: Reactome:REACT_102880 "p75NTR negatively regulates cell cycle via SC1, Xenopus tropicalis"
xref: Reactome:REACT_112803 "p75NTR negatively regulates cell cycle via SC1, Drosophila melanogaster"
xref: Reactome:REACT_13695 "p75NTR negatively regulates cell cycle via SC1, Homo sapiens"
xref: Reactome:REACT_31060 "p75NTR negatively regulates cell cycle via SC1, Rattus norvegicus"
xref: Reactome:REACT_32970 "p75NTR negatively regulates cell cycle via SC1, Sus scrofa"
xref: Reactome:REACT_78219 "p75NTR negatively regulates cell cycle via SC1, Gallus gallus"
xref: Reactome:REACT_83256 "p75NTR negatively regulates cell cycle via SC1, Bos taurus"
xref: Reactome:REACT_88108 "p75NTR negatively regulates cell cycle via SC1, Canis familiaris"
xref: Reactome:REACT_93253 "p75NTR negatively regulates cell cycle via SC1, Danio rerio"
xref: Reactome:REACT_99982 "p75NTR negatively regulates cell cycle via SC1, Mus musculus"
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051726 ! regulation of cell cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007049 ! cell cycle
relationship: negatively_regulates GO:0007049 ! cell cycle

[Term]
id: GO:0045787
name: positive regulation of cell cycle
namespace: biological_process
def: "Any process that activates or increases the rate or extent of progression through the cell cycle." [GOC:go_curators]
synonym: "activation of progression through cell cycle" NARROW []
synonym: "positive regulation of cell cycle progression" EXACT []
synonym: "positive regulation of progression through cell cycle" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of progression through cell cycle" NARROW []
synonym: "up regulation of progression through cell cycle" EXACT []
synonym: "up-regulation of progression through cell cycle" EXACT []
synonym: "upregulation of progression through cell cycle" EXACT []
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051726 ! regulation of cell cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007049 ! cell cycle
relationship: positively_regulates GO:0007049 ! cell cycle

[Term]
id: GO:0045792
name: negative regulation of cell size
namespace: biological_process
def: "Any process that reduces cell size." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of cell size" EXACT []
synonym: "down-regulation of cell size" EXACT []
synonym: "downregulation of cell size" EXACT []
synonym: "inhibition of cell size" NARROW []
is_a: GO:0008361 ! regulation of cell size

[Term]
id: GO:0045793
name: positive regulation of cell size
namespace: biological_process
def: "Any process that increases cell size." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of cell size" NARROW []
synonym: "stimulation of cell size" NARROW []
synonym: "up regulation of cell size" EXACT []
synonym: "up-regulation of cell size" EXACT []
synonym: "upregulation of cell size" EXACT []
xref: Reactome:REACT_6260 "Activation of DAkt1 by DPDK1, Drosophila melanogaster"
is_a: GO:0008361 ! regulation of cell size

[Term]
id: GO:0045794
name: negative regulation of cell volume
namespace: biological_process
def: "Any process that decreases cell volume." [GOC:go_curators]
synonym: "cell regulatory volume decrease" RELATED [PMID:12388065]
synonym: "RVD" RELATED [PMID:12388065]
is_a: GO:0006884 ! cell volume homeostasis

[Term]
id: GO:0045795
name: positive regulation of cell volume
namespace: biological_process
def: "Any process that increases cell volume." [GOC:go_curators]
is_a: GO:0006884 ! cell volume homeostasis

[Term]
id: GO:0045796
name: negative regulation of intestinal cholesterol absorption
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of uptake of cholesterol into the blood by absorption from the intestine." [GOC:go_curators]
synonym: "down regulation of cholesterol absorption" EXACT []
synonym: "down-regulation of cholesterol absorption" EXACT []
synonym: "downregulation of cholesterol absorption" EXACT []
synonym: "inhibition of cholesterol absorption" NARROW []
is_a: GO:0030300 ! regulation of intestinal cholesterol absorption
is_a: GO:0032375 ! negative regulation of cholesterol transport
is_a: GO:1904730 ! negative regulation of intestinal lipid absorption
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030299 ! intestinal cholesterol absorption
relationship: negatively_regulates GO:0030299 ! intestinal cholesterol absorption

[Term]
id: GO:0045797
name: positive regulation of intestinal cholesterol absorption
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of uptake of cholesterol into the blood by absorption from the intestine." [GOC:go_curators]
synonym: "activation of cholesterol absorption" NARROW []
synonym: "stimulation of cholesterol absorption" NARROW []
synonym: "up regulation of cholesterol absorption" EXACT []
synonym: "up-regulation of cholesterol absorption" EXACT []
synonym: "upregulation of cholesterol absorption" EXACT []
is_a: GO:0030300 ! regulation of intestinal cholesterol absorption
is_a: GO:0032376 ! positive regulation of cholesterol transport
is_a: GO:1904731 ! positive regulation of intestinal lipid absorption
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030299 ! intestinal cholesterol absorption
relationship: positively_regulates GO:0030299 ! intestinal cholesterol absorption

[Term]
id: GO:0045798
name: negative regulation of chromatin assembly or disassembly
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chromatin assembly or disassembly." [GOC:go_curators]
synonym: "down regulation of chromatin assembly or disassembly" EXACT []
synonym: "down-regulation of chromatin assembly or disassembly" EXACT []
synonym: "downregulation of chromatin assembly or disassembly" EXACT []
synonym: "inhibition of chromatin assembly or disassembly" NARROW []
synonym: "negative regulation of chromatin assembly/disassembly" EXACT []
is_a: GO:0001672 ! regulation of chromatin assembly or disassembly
is_a: GO:2001251 ! negative regulation of chromosome organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006333 ! chromatin assembly or disassembly
relationship: negatively_regulates GO:0006333 ! chromatin assembly or disassembly

[Term]
id: GO:0045799
name: positive regulation of chromatin assembly or disassembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chromatin assembly or disassembly." [GOC:go_curators]
synonym: "activation of chromatin assembly or disassembly" NARROW []
synonym: "positive regulation of chromatin assembly/disassembly" EXACT []
synonym: "stimulation of chromatin assembly or disassembly" NARROW []
synonym: "up regulation of chromatin assembly or disassembly" EXACT []
synonym: "up-regulation of chromatin assembly or disassembly" EXACT []
synonym: "upregulation of chromatin assembly or disassembly" EXACT []
is_a: GO:0001672 ! regulation of chromatin assembly or disassembly
is_a: GO:2001252 ! positive regulation of chromosome organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006333 ! chromatin assembly or disassembly
relationship: positively_regulates GO:0006333 ! chromatin assembly or disassembly

[Term]
id: GO:0045800
name: negative regulation of chitin-based cuticle tanning
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chitin-based cuticular tanning." [GOC:go_curators, GOC:jid, GOC:mtg_sensu]
synonym: "down regulation of cuticle tanning" EXACT []
synonym: "down-regulation of cuticle tanning" EXACT []
synonym: "downregulation of cuticle tanning" EXACT []
synonym: "inhibition of cuticle tanning" NARROW []
synonym: "negative regulation of cuticle hardening" NARROW []
synonym: "negative regulation of cuticle tanning" EXACT []
is_a: GO:0007564 ! regulation of chitin-based cuticle tanning
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007593 ! chitin-based cuticle sclerotization
relationship: negatively_regulates GO:0007593 ! chitin-based cuticle sclerotization

[Term]
id: GO:0045801
name: positive regulation of chitin-based cuticle tanning
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chitin-based cuticular tanning." [GOC:go_curators, GOC:jid, GOC:mtg_sensu]
synonym: "activation of cuticle tanning" NARROW []
synonym: "positive regulation of cuticle hardening" NARROW []
synonym: "positive regulation of cuticle tanning" EXACT []
synonym: "stimulation of cuticle tanning" NARROW []
synonym: "up regulation of cuticle tanning" EXACT []
synonym: "up-regulation of cuticle tanning" EXACT []
synonym: "upregulation of cuticle tanning" EXACT []
is_a: GO:0007564 ! regulation of chitin-based cuticle tanning
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007593 ! chitin-based cuticle sclerotization
relationship: positively_regulates GO:0007593 ! chitin-based cuticle sclerotization

[Term]
id: GO:0045802
name: obsolete negative regulation of cytoskeleton
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the organization, biogenesis or maintenance of the cytoskeleton." [GOC:go_curators]
comment: This term was made obsolete because cytoskeleton is not a process, so the term made no sense.
synonym: "negative regulation of cytoskeleton" EXACT []
is_obsolete: true
consider: GO:0007010

[Term]
id: GO:0045803
name: obsolete positive regulation of cytoskeleton
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the organization, biogenesis or maintenance of the cytoskeleton." [GOC:go_curators]
comment: This term was made obsolete because cytoskeleton is not a process, so the term made no sense.
synonym: "positive regulation of cytoskeleton" EXACT []
is_obsolete: true
consider: GO:0007010

[Term]
id: GO:0045804
name: negative regulation of eclosion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of eclosion." [GOC:go_curators]
synonym: "down regulation of eclosion" EXACT []
synonym: "down-regulation of eclosion" EXACT []
synonym: "downregulation of eclosion" EXACT []
synonym: "inhibition of eclosion" NARROW []
is_a: GO:0007563 ! regulation of eclosion
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007562 ! eclosion
relationship: negatively_regulates GO:0007562 ! eclosion

[Term]
id: GO:0045805
name: positive regulation of eclosion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of eclosion." [GOC:go_curators]
synonym: "activation of eclosion" NARROW []
synonym: "stimulation of eclosion" NARROW []
synonym: "up regulation of eclosion" EXACT []
synonym: "up-regulation of eclosion" EXACT []
synonym: "upregulation of eclosion" EXACT []
is_a: GO:0007563 ! regulation of eclosion
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007562 ! eclosion
relationship: positively_regulates GO:0007562 ! eclosion

[Term]
id: GO:0045806
name: negative regulation of endocytosis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis." [GOC:go_curators]
synonym: "down regulation of endocytosis" EXACT []
synonym: "down-regulation of endocytosis" EXACT []
synonym: "downregulation of endocytosis" EXACT []
synonym: "inhibition of endocytosis" NARROW []
is_a: GO:0030100 ! regulation of endocytosis
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:0051129 ! negative regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006897 ! endocytosis
relationship: negatively_regulates GO:0006897 ! endocytosis

[Term]
id: GO:0045807
name: positive regulation of endocytosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endocytosis." [GOC:go_curators]
synonym: "activation of endocytosis" NARROW []
synonym: "stimulation of endocytosis" NARROW []
synonym: "up regulation of endocytosis" EXACT []
synonym: "up-regulation of endocytosis" EXACT []
synonym: "upregulation of endocytosis" EXACT []
is_a: GO:0030100 ! regulation of endocytosis
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:0051130 ! positive regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006897 ! endocytosis
relationship: positively_regulates GO:0006897 ! endocytosis

[Term]
id: GO:0045808
name: negative regulation of establishment of competence for transformation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of competence for transformation." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of establishment of competence for transformation" EXACT []
synonym: "down-regulation of establishment of competence for transformation" EXACT []
synonym: "downregulation of establishment of competence for transformation" EXACT []
synonym: "inhibition of establishment of competence for transformation" NARROW []
synonym: "inhibitor of the establishment of competence for transformation activity" RELATED []
is_a: GO:0010648 ! negative regulation of cell communication
is_a: GO:0032105 ! negative regulation of response to extracellular stimulus
is_a: GO:0043901 ! negative regulation of multi-organism process
is_a: GO:0045304 ! regulation of establishment of competence for transformation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030420 ! establishment of competence for transformation
relationship: negatively_regulates GO:0030420 ! establishment of competence for transformation

[Term]
id: GO:0045809
name: positive regulation of establishment of competence for transformation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment of competence for transformation." [GOC:go_curators]
synonym: "activation of establishment of competence for transformation" NARROW []
synonym: "activator of the establishment of competence for transformation activity" RELATED []
synonym: "stimulation of establishment of competence for transformation" NARROW []
synonym: "up regulation of establishment of competence for transformation" EXACT []
synonym: "up-regulation of establishment of competence for transformation" EXACT []
synonym: "upregulation of establishment of competence for transformation" EXACT []
is_a: GO:0010647 ! positive regulation of cell communication
is_a: GO:0032106 ! positive regulation of response to extracellular stimulus
is_a: GO:0043902 ! positive regulation of multi-organism process
is_a: GO:0045304 ! regulation of establishment of competence for transformation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030420 ! establishment of competence for transformation
relationship: positively_regulates GO:0030420 ! establishment of competence for transformation

[Term]
id: GO:0045812
name: negative regulation of Wnt signaling pathway, calcium modulating pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC)." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "down regulation of frizzled-2 signaling pathway" EXACT []
synonym: "down-regulation of frizzled-2 signaling pathway" EXACT []
synonym: "downregulation of frizzled-2 signaling pathway" EXACT []
synonym: "inhibition of frizzled-2 signaling pathway" NARROW []
synonym: "negative regulation of frizzled-2 signaling pathway" EXACT []
synonym: "negative regulation of frizzled-2 signalling pathway" EXACT []
synonym: "negative regulation of Wnt receptor signaling pathway, calcium modulating pathway" EXACT []
synonym: "negative regulation of Wnt-activated signaling pathway, calcium modulating pathway" EXACT [GOC:signaling]
is_a: GO:0008591 ! regulation of Wnt signaling pathway, calcium modulating pathway
is_a: GO:2000051 ! negative regulation of non-canonical Wnt signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007223 ! Wnt signaling pathway, calcium modulating pathway
relationship: negatively_regulates GO:0007223 ! Wnt signaling pathway, calcium modulating pathway

[Term]
id: GO:0045813
name: positive regulation of Wnt signaling pathway, calcium modulating pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC)." [GOC:go_curators]
synonym: "activation of frizzled-2 signaling pathway" NARROW []
synonym: "positive regulation of frizzled-2 signaling pathway" EXACT []
synonym: "positive regulation of frizzled-2 signalling pathway" EXACT []
synonym: "positive regulation of Wnt receptor signaling pathway, calcium modulating pathway" EXACT []
synonym: "positive regulation of Wnt-activated signaling pathway, calcium modulating pathway" EXACT [GOC:signaling]
synonym: "stimulation of frizzled-2 signaling pathway" NARROW []
synonym: "up regulation of frizzled-2 signaling pathway" EXACT []
synonym: "up-regulation of frizzled-2 signaling pathway" EXACT []
synonym: "upregulation of frizzled-2 signaling pathway" EXACT []
is_a: GO:0008591 ! regulation of Wnt signaling pathway, calcium modulating pathway
is_a: GO:2000052 ! positive regulation of non-canonical Wnt signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007223 ! Wnt signaling pathway, calcium modulating pathway
relationship: positively_regulates GO:0007223 ! Wnt signaling pathway, calcium modulating pathway

[Term]
id: GO:0045814
name: negative regulation of gene expression, epigenetic
namespace: biological_process
def: "Any epigenetic process that stops, prevents or reduces the rate of gene expression." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of gene expression, epigenetic" EXACT []
synonym: "down-regulation of gene expression, epigenetic" EXACT []
synonym: "downregulation of gene expression, epigenetic" EXACT []
synonym: "inhibition of gene expression, epigenetic" NARROW []
is_a: GO:0010629 ! negative regulation of gene expression
is_a: GO:0040029 ! regulation of gene expression, epigenetic

[Term]
id: GO:0045815
name: positive regulation of gene expression, epigenetic
namespace: biological_process
def: "Any epigenetic process that activates or increases the rate of gene expression." [GOC:go_curators]
synonym: "activation of gene expression, epigenetic" NARROW []
synonym: "stimulation of gene expression, epigenetic" NARROW []
synonym: "up regulation of gene expression, epigenetic" EXACT []
synonym: "up-regulation of gene expression, epigenetic" EXACT []
synonym: "upregulation of gene expression, epigenetic" EXACT []
is_a: GO:0010628 ! positive regulation of gene expression
is_a: GO:0040029 ! regulation of gene expression, epigenetic

[Term]
id: GO:0045818
name: negative regulation of glycogen catabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of glycogen catabolic process" EXACT []
synonym: "down-regulation of glycogen catabolic process" EXACT []
synonym: "downregulation of glycogen catabolic process" EXACT []
synonym: "inhibition of glycogen catabolic process" NARROW []
synonym: "negative regulation of glycogen breakdown" EXACT []
synonym: "negative regulation of glycogen catabolism" EXACT []
synonym: "negative regulation of glycogen degradation" EXACT []
synonym: "negative regulation of glycogenolysis" EXACT [GOC:sl]
is_a: GO:0005981 ! regulation of glycogen catabolic process
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:0070874 ! negative regulation of glycogen metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0005980 ! glycogen catabolic process
relationship: negatively_regulates GO:0005980 ! glycogen catabolic process

[Term]
id: GO:0045819
name: positive regulation of glycogen catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of glycogen catabolic process" NARROW []
synonym: "positive regulation of glycogen breakdown" EXACT []
synonym: "positive regulation of glycogen catabolism" EXACT []
synonym: "positive regulation of glycogen degradation" EXACT []
synonym: "positive regulation of glycogenolysis" EXACT [GOC:sl]
synonym: "stimulation of glycogen catabolic process" NARROW []
synonym: "up regulation of glycogen catabolic process" EXACT []
synonym: "up-regulation of glycogen catabolic process" EXACT []
synonym: "upregulation of glycogen catabolic process" EXACT []
is_a: GO:0005981 ! regulation of glycogen catabolic process
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:0070875 ! positive regulation of glycogen metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0005980 ! glycogen catabolic process
relationship: positively_regulates GO:0005980 ! glycogen catabolic process

[Term]
id: GO:0045820
name: negative regulation of glycolytic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of glycolysis." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of glycolysis" EXACT []
synonym: "down-regulation of glycolysis" EXACT []
synonym: "downregulation of glycolysis" EXACT []
synonym: "inhibition of glycolysis" NARROW []
is_a: GO:0006110 ! regulation of glycolytic process
is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process
is_a: GO:0030812 ! negative regulation of nucleotide catabolic process
is_a: GO:0042326 ! negative regulation of phosphorylation
is_a: GO:0051198 ! negative regulation of coenzyme metabolic process
is_a: GO:1903579 ! negative regulation of ATP metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006096 ! glycolytic process
relationship: negatively_regulates GO:0006096 ! glycolytic process

[Term]
id: GO:0045821
name: positive regulation of glycolytic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glycolysis." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of glycolysis" NARROW []
synonym: "stimulation of glycolysis" NARROW []
synonym: "up regulation of glycolysis" EXACT []
synonym: "up-regulation of glycolysis" EXACT []
synonym: "upregulation of glycolysis" EXACT []
is_a: GO:0006110 ! regulation of glycolytic process
is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process
is_a: GO:0030813 ! positive regulation of nucleotide catabolic process
is_a: GO:0042327 ! positive regulation of phosphorylation
is_a: GO:0051197 ! positive regulation of coenzyme metabolic process
is_a: GO:1903580 ! positive regulation of ATP metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006096 ! glycolytic process
relationship: positively_regulates GO:0006096 ! glycolytic process

[Term]
id: GO:0045822
name: negative regulation of heart contraction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction." [GOC:go_curators]
synonym: "down regulation of heart contraction" EXACT []
synonym: "down-regulation of heart contraction" EXACT []
synonym: "downregulation of heart contraction" EXACT []
synonym: "inhibition of heart contraction" NARROW []
synonym: "negative regulation of cardiac contraction" RELATED []
is_a: GO:0008016 ! regulation of heart contraction
is_a: GO:1903523 ! negative regulation of blood circulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060047 ! heart contraction
relationship: negatively_regulates GO:0060047 ! heart contraction

[Term]
id: GO:0045823
name: positive regulation of heart contraction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of heart contraction." [GOC:go_curators]
synonym: "activation of heart contraction" NARROW []
synonym: "positive regulation of cardiac contraction" EXACT []
synonym: "stimulation of heart contraction" NARROW []
synonym: "up regulation of heart contraction" EXACT []
synonym: "up-regulation of heart contraction" EXACT []
synonym: "upregulation of heart contraction" EXACT []
is_a: GO:0008016 ! regulation of heart contraction
is_a: GO:1903524 ! positive regulation of blood circulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060047 ! heart contraction
relationship: positively_regulates GO:0060047 ! heart contraction

[Term]
id: GO:0045824
name: negative regulation of innate immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response." [GOC:go_curators]
synonym: "down regulation of innate immune response" EXACT []
synonym: "down-regulation of innate immune response" EXACT []
synonym: "downregulation of innate immune response" EXACT []
synonym: "inhibition of innate immune response" NARROW []
xref: Reactome:REACT_75851 "Negative Regulation of MDA5 signaling, Gallus gallus"
is_a: GO:0031348 ! negative regulation of defense response
is_a: GO:0045088 ! regulation of innate immune response
is_a: GO:0050777 ! negative regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045087 ! innate immune response
relationship: negatively_regulates GO:0045087 ! innate immune response

[Term]
id: GO:0045825
name: obsolete negative regulation of intermediate filament polymerization and/or depolymerization
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of intermediate filament polymerization and/or depolymerization." [GOC:go_curators]
comment: This term was made obsolete because it has been split.
synonym: "negative regulation of intermediate filament polymerization and/or depolymerization" EXACT []
is_obsolete: true
consider: GO:0030840
consider: GO:0030843

[Term]
id: GO:0045826
name: obsolete positive regulation of intermediate filament polymerization and/or depolymerization
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of intermediate filament polymerization and/or depolymerization." [GOC:go_curators]
comment: This term was made obsolete because it has been split.
synonym: "positive regulation of intermediate filament polymerization and/or depolymerization" EXACT []
is_obsolete: true
consider: GO:0030841
consider: GO:0030844

[Term]
id: GO:0045827
name: negative regulation of isoprenoid metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving isoprenoid." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of isoprenoid metabolic process" EXACT []
synonym: "down-regulation of isoprenoid metabolic process" EXACT []
synonym: "downregulation of isoprenoid metabolic process" EXACT []
synonym: "inhibition of isoprenoid metabolic process" NARROW []
synonym: "negative regulation of isoprenoid metabolism" EXACT []
is_a: GO:0019747 ! regulation of isoprenoid metabolic process
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0045833 ! negative regulation of lipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006720 ! isoprenoid metabolic process
relationship: negatively_regulates GO:0006720 ! isoprenoid metabolic process

[Term]
id: GO:0045828
name: positive regulation of isoprenoid metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving isoprenoid." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of isoprenoid metabolic process" NARROW []
synonym: "positive regulation of isoprenoid metabolism" EXACT []
synonym: "stimulation of isoprenoid metabolic process" NARROW []
synonym: "up regulation of isoprenoid metabolic process" EXACT []
synonym: "up-regulation of isoprenoid metabolic process" EXACT []
synonym: "upregulation of isoprenoid metabolic process" EXACT []
is_a: GO:0019747 ! regulation of isoprenoid metabolic process
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0045834 ! positive regulation of lipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006720 ! isoprenoid metabolic process
relationship: positively_regulates GO:0006720 ! isoprenoid metabolic process

[Term]
id: GO:0045829
name: negative regulation of isotype switching
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching." [GOC:go_curators]
synonym: "down regulation of isotype switching" EXACT []
synonym: "down-regulation of isotype switching" EXACT []
synonym: "downregulation of isotype switching" EXACT []
synonym: "inhibition of isotype switching" NARROW []
synonym: "negative regulation of class switch recombination" EXACT []
synonym: "negative regulation of class switching" EXACT []
synonym: "negative regulation of isotype switch recombination" EXACT []
is_a: GO:0002638 ! negative regulation of immunoglobulin production
is_a: GO:0002890 ! negative regulation of immunoglobulin mediated immune response
is_a: GO:0045191 ! regulation of isotype switching
is_a: GO:0045910 ! negative regulation of DNA recombination
is_a: GO:0050869 ! negative regulation of B cell activation
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045190 ! isotype switching
relationship: negatively_regulates GO:0045190 ! isotype switching

[Term]
id: GO:0045830
name: positive regulation of isotype switching
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of isotype switching." [GOC:go_curators]
synonym: "activation of isotype switching" NARROW []
synonym: "positive regulation of class switch recombination" EXACT []
synonym: "positive regulation of class switching" EXACT []
synonym: "positive regulation of isotype switch recombination" EXACT []
synonym: "stimulation of isotype switching" NARROW []
synonym: "up regulation of isotype switching" EXACT []
synonym: "up-regulation of isotype switching" EXACT []
synonym: "upregulation of isotype switching" EXACT []
is_a: GO:0002639 ! positive regulation of immunoglobulin production
is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response
is_a: GO:0045191 ! regulation of isotype switching
is_a: GO:0045911 ! positive regulation of DNA recombination
is_a: GO:0050871 ! positive regulation of B cell activation
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045190 ! isotype switching
relationship: positively_regulates GO:0045190 ! isotype switching

[Term]
id: GO:0045831
name: negative regulation of light-activated channel activity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of light-activated channel activity." [GOC:go_curators]
synonym: "down regulation of light-activated channel activity" EXACT []
synonym: "down-regulation of light-activated channel activity" EXACT []
synonym: "downregulation of light-activated channel activity" EXACT []
synonym: "inhibition of light-activated channel activity" NARROW []
is_a: GO:0016061 ! regulation of light-activated channel activity
is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010461 ! light-activated ion channel activity
relationship: negatively_regulates GO:0010461 ! light-activated ion channel activity

[Term]
id: GO:0045832
name: positive regulation of light-activated channel activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of light-activated channel activity." [GOC:go_curators]
synonym: "activation of light-activated channel activity" NARROW []
synonym: "stimulation of light-activated channel activity" NARROW []
synonym: "up regulation of light-activated channel activity" EXACT []
synonym: "up-regulation of light-activated channel activity" EXACT []
synonym: "upregulation of light-activated channel activity" EXACT []
is_a: GO:0016061 ! regulation of light-activated channel activity
is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010461 ! light-activated ion channel activity
relationship: positively_regulates GO:0010461 ! light-activated ion channel activity

[Term]
id: GO:0045833
name: negative regulation of lipid metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of lipid metabolic process" EXACT []
synonym: "down-regulation of lipid metabolic process" EXACT []
synonym: "downregulation of lipid metabolic process" EXACT []
synonym: "inhibition of lipid metabolic process" NARROW []
synonym: "negative regulation of lipid metabolism" EXACT []
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0019216 ! regulation of lipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006629 ! lipid metabolic process
relationship: negatively_regulates GO:0006629 ! lipid metabolic process

[Term]
id: GO:0045834
name: positive regulation of lipid metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of lipid metabolic process" NARROW []
synonym: "positive regulation of lipid metabolism" EXACT []
synonym: "stimulation of lipid metabolic process" NARROW []
synonym: "up regulation of lipid metabolic process" EXACT []
synonym: "up-regulation of lipid metabolic process" EXACT []
synonym: "upregulation of lipid metabolic process" EXACT []
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0019216 ! regulation of lipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006629 ! lipid metabolic process
relationship: positively_regulates GO:0006629 ! lipid metabolic process

[Term]
id: GO:0045835
name: negative regulation of meiotic nuclear division
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis." [GOC:go_curators]
synonym: "down regulation of meiosis" EXACT []
synonym: "down-regulation of meiosis" EXACT []
synonym: "downregulation of meiosis" EXACT []
synonym: "inhibition of meiosis" NARROW []
synonym: "negative regulation of meiosis" EXACT []
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0040020 ! regulation of meiotic nuclear division
is_a: GO:0051447 ! negative regulation of meiotic cell cycle
is_a: GO:0051784 ! negative regulation of nuclear division
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007126 ! meiotic nuclear division
relationship: negatively_regulates GO:0007126 ! meiotic nuclear division

[Term]
id: GO:0045836
name: positive regulation of meiotic nuclear division
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of meiosis." [GOC:go_curators]
synonym: "activation of meiosis" NARROW []
synonym: "positive regulation of meiosis" EXACT []
synonym: "stimulation of meiosis" NARROW []
synonym: "up regulation of meiosis" EXACT []
synonym: "up-regulation of meiosis" EXACT []
synonym: "upregulation of meiosis" EXACT []
is_a: GO:0040020 ! regulation of meiotic nuclear division
is_a: GO:0051446 ! positive regulation of meiotic cell cycle
is_a: GO:0051785 ! positive regulation of nuclear division
is_a: GO:0090068 ! positive regulation of cell cycle process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007126 ! meiotic nuclear division
relationship: positively_regulates GO:0007126 ! meiotic nuclear division

[Term]
id: GO:0045837
name: negative regulation of membrane potential
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:go_curators]
synonym: "down regulation of membrane potential" EXACT []
synonym: "down-regulation of membrane potential" EXACT []
synonym: "downregulation of membrane potential" EXACT []
synonym: "inhibition of membrane potential" NARROW []
synonym: "reduction of membrane potential" EXACT [GOC:rph]
is_a: GO:0042391 ! regulation of membrane potential

[Term]
id: GO:0045838
name: positive regulation of membrane potential
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:go_curators]
synonym: "activation of membrane potential" NARROW []
synonym: "elevation of membrane potential" EXACT [GOC:rph]
synonym: "stimulation of membrane potential" NARROW []
synonym: "up regulation of membrane potential" EXACT []
synonym: "up-regulation of membrane potential" EXACT []
synonym: "upregulation of membrane potential" EXACT []
is_a: GO:0042391 ! regulation of membrane potential

[Term]
id: GO:0045839
name: negative regulation of mitotic nuclear division
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "down regulation of mitosis" EXACT []
synonym: "down-regulation of mitosis" EXACT []
synonym: "downregulation of mitosis" EXACT []
synonym: "inhibition of mitosis" NARROW []
synonym: "negative regulation of mitosis" EXACT []
is_a: GO:0007088 ! regulation of mitotic nuclear division
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0045930 ! negative regulation of mitotic cell cycle
is_a: GO:0051784 ! negative regulation of nuclear division
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007067 ! mitotic nuclear division
relationship: negatively_regulates GO:0007067 ! mitotic nuclear division

[Term]
id: GO:0045840
name: positive regulation of mitotic nuclear division
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitosis." [GOC:go_curators]
synonym: "activation of mitosis" NARROW []
synonym: "mitogenic activity" NARROW []
synonym: "positive regulation of mitosis" EXACT []
synonym: "stimulation of mitosis" NARROW []
synonym: "up regulation of mitosis" EXACT []
synonym: "up-regulation of mitosis" EXACT []
synonym: "upregulation of mitosis" EXACT []
is_a: GO:0007088 ! regulation of mitotic nuclear division
is_a: GO:0045931 ! positive regulation of mitotic cell cycle
is_a: GO:0051785 ! positive regulation of nuclear division
is_a: GO:0090068 ! positive regulation of cell cycle process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007067 ! mitotic nuclear division
relationship: positively_regulates GO:0007067 ! mitotic nuclear division

[Term]
id: GO:0045841
name: negative regulation of mitotic metaphase/anaphase transition
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the mitotic metaphase to anaphase transition." [GOC:go_curators]
synonym: "down regulation of mitotic metaphase/anaphase transition" EXACT []
synonym: "down-regulation of mitotic metaphase/anaphase transition" EXACT []
synonym: "downregulation of mitotic metaphase/anaphase transition" EXACT []
synonym: "inhibition of mitotic metaphase/anaphase transition" NARROW []
is_a: GO:0030071 ! regulation of mitotic metaphase/anaphase transition
is_a: GO:0032435 ! negative regulation of proteasomal ubiquitin-dependent protein catabolic process
is_a: GO:1901991 ! negative regulation of mitotic cell cycle phase transition
is_a: GO:1902100 ! negative regulation of metaphase/anaphase transition of cell cycle
is_a: GO:2000816 ! negative regulation of mitotic sister chromatid separation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007091 ! metaphase/anaphase transition of mitotic cell cycle
relationship: negatively_regulates GO:0007091 ! metaphase/anaphase transition of mitotic cell cycle

[Term]
id: GO:0045842
name: positive regulation of mitotic metaphase/anaphase transition
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the mitotic metaphase to anaphase transition." [GOC:go_curators]
synonym: "activation of mitotic metaphase/anaphase transition" NARROW []
synonym: "stimulation of mitotic metaphase/anaphase transition" NARROW []
synonym: "up regulation of mitotic metaphase/anaphase transition" EXACT []
synonym: "up-regulation of mitotic metaphase/anaphase transition" EXACT []
synonym: "upregulation of mitotic metaphase/anaphase transition" EXACT []
is_a: GO:0030071 ! regulation of mitotic metaphase/anaphase transition
is_a: GO:0032436 ! positive regulation of proteasomal ubiquitin-dependent protein catabolic process
is_a: GO:1901970 ! positive regulation of mitotic sister chromatid separation
is_a: GO:1901992 ! positive regulation of mitotic cell cycle phase transition
is_a: GO:1902101 ! positive regulation of metaphase/anaphase transition of cell cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007091 ! metaphase/anaphase transition of mitotic cell cycle
relationship: positively_regulates GO:0007091 ! metaphase/anaphase transition of mitotic cell cycle

[Term]
id: GO:0045843
name: negative regulation of striated muscle tissue development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle development." [GOC:go_curators]
synonym: "down regulation of striated muscle development" EXACT []
synonym: "down-regulation of striated muscle development" EXACT []
synonym: "downregulation of striated muscle development" EXACT []
synonym: "inhibition of striated muscle development" NARROW []
is_a: GO:0016202 ! regulation of striated muscle tissue development
is_a: GO:0048635 ! negative regulation of muscle organ development
is_a: GO:1901862 ! negative regulation of muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0014706 ! striated muscle tissue development
relationship: negatively_regulates GO:0014706 ! striated muscle tissue development

[Term]
id: GO:0045844
name: positive regulation of striated muscle tissue development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of striated muscle development." [GOC:go_curators]
synonym: "activation of striated muscle development" NARROW []
synonym: "stimulation of striated muscle development" NARROW []
synonym: "up regulation of striated muscle development" EXACT []
synonym: "up-regulation of striated muscle development" EXACT []
synonym: "upregulation of striated muscle development" EXACT []
is_a: GO:0016202 ! regulation of striated muscle tissue development
is_a: GO:0048636 ! positive regulation of muscle organ development
is_a: GO:1901863 ! positive regulation of muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0014706 ! striated muscle tissue development
relationship: positively_regulates GO:0014706 ! striated muscle tissue development

[Term]
id: GO:0045847
name: negative regulation of nitrogen utilization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of nitrogen utilization." [GOC:go_curators]
synonym: "down regulation of nitrogen utilization" EXACT []
synonym: "down-regulation of nitrogen utilization" EXACT []
synonym: "downregulation of nitrogen utilization" EXACT []
synonym: "inhibition of nitrogen utilization" NARROW []
is_a: GO:0006808 ! regulation of nitrogen utilization
is_a: GO:0048519 ! negative regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019740 ! nitrogen utilization
relationship: negatively_regulates GO:0019740 ! nitrogen utilization

[Term]
id: GO:0045848
name: positive regulation of nitrogen utilization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of nitrogen utilization." [GOC:go_curators]
synonym: "activation of nitrogen utilization" NARROW []
synonym: "stimulation of nitrogen utilization" NARROW []
synonym: "up regulation of nitrogen utilization" EXACT []
synonym: "up-regulation of nitrogen utilization" EXACT []
synonym: "upregulation of nitrogen utilization" EXACT []
is_a: GO:0006808 ! regulation of nitrogen utilization
is_a: GO:0048518 ! positive regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0019740 ! nitrogen utilization
relationship: positively_regulates GO:0019740 ! nitrogen utilization

[Term]
id: GO:0045849
name: negative regulation of nurse cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of nurse cell apoptotic process." [GOC:go_curators, GOC:mtg_apoptosis]
synonym: "down regulation of nurse cell apoptosis" EXACT []
synonym: "down-regulation of nurse cell apoptosis" EXACT []
synonym: "downregulation of nurse cell apoptosis" EXACT []
synonym: "inhibition of nurse cell apoptosis" NARROW []
synonym: "negative regulation of nurse cell apoptosis" NARROW []
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0043901 ! negative regulation of multi-organism process
is_a: GO:0045477 ! regulation of nurse cell apoptotic process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1904746 ! negative regulation of apoptotic process involved in development
is_a: GO:2000242 ! negative regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045476 ! nurse cell apoptotic process
relationship: negatively_regulates GO:0045476 ! nurse cell apoptotic process

[Term]
id: GO:0045850
name: positive regulation of nurse cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of nurse cell apoptotic process." [GOC:go_curators, GOC:mtg_apoptosis]
synonym: "activation of nurse cell apoptosis" NARROW []
synonym: "positive regulation of nurse cell apoptosis" NARROW []
synonym: "stimulation of nurse cell apoptosis" NARROW []
synonym: "up regulation of nurse cell apoptosis" EXACT []
synonym: "up-regulation of nurse cell apoptosis" EXACT []
synonym: "upregulation of nurse cell apoptosis" EXACT []
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0043902 ! positive regulation of multi-organism process
is_a: GO:0045477 ! regulation of nurse cell apoptotic process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1904747 ! positive regulation of apoptotic process involved in development
is_a: GO:2000243 ! positive regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045476 ! nurse cell apoptotic process
relationship: positively_regulates GO:0045476 ! nurse cell apoptotic process

[Term]
id: GO:0045851
name: pH reduction
namespace: biological_process
def: "Any process that reduces the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion." [GOC:go_curators]
synonym: "acidification" EXACT []
is_a: GO:0006885 ! regulation of pH

[Term]
id: GO:0045852
name: pH elevation
namespace: biological_process
def: "Any process that increases the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion." [GOC:go_curators]
is_a: GO:0006885 ! regulation of pH

[Term]
id: GO:0045853
name: negative regulation of bicoid mRNA localization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the process in which bicoid mRNA is transported to, or maintained in, a specific location." [GOC:go_curators]
synonym: "down regulation of bicoid mRNA localization" EXACT []
synonym: "down-regulation of bicoid mRNA localization" EXACT []
synonym: "downregulation of bicoid mRNA localization" EXACT []
synonym: "inhibition of bicoid mRNA localization" NARROW []
synonym: "negative regulation of bicoid mRNA localisation" EXACT [GOC:mah]
is_a: GO:0008359 ! regulation of bicoid mRNA localization
is_a: GO:0060283 ! negative regulation of oocyte development
is_a: GO:1902876 ! negative regulation of embryonic pattern specification
is_a: GO:1903430 ! negative regulation of cell maturation
is_a: GO:1904581 ! negative regulation of intracellular mRNA localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045450 ! bicoid mRNA localization
relationship: negatively_regulates GO:0045450 ! bicoid mRNA localization

[Term]
id: GO:0045854
name: positive regulation of bicoid mRNA localization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the process in which bicoid mRNA is transported to, or maintained in, a specific location." [GOC:go_curators]
synonym: "activation of bicoid mRNA localization" NARROW []
synonym: "positive regulation of bicoid mRNA localisation" EXACT [GOC:mah]
synonym: "stimulation of bicoid mRNA localization" NARROW []
synonym: "up regulation of bicoid mRNA localization" EXACT []
synonym: "up-regulation of bicoid mRNA localization" EXACT []
synonym: "upregulation of bicoid mRNA localization" EXACT []
is_a: GO:0008359 ! regulation of bicoid mRNA localization
is_a: GO:0060282 ! positive regulation of oocyte development
is_a: GO:1902877 ! positive regulation of embryonic pattern specification
is_a: GO:1903431 ! positive regulation of cell maturation
is_a: GO:1904582 ! positive regulation of intracellular mRNA localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045450 ! bicoid mRNA localization
relationship: positively_regulates GO:0045450 ! bicoid mRNA localization

[Term]
id: GO:0045855
name: negative regulation of pole plasm oskar mRNA localization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators]
synonym: "down regulation of pole plasm oskar mRNA localization" EXACT []
synonym: "down-regulation of pole plasm oskar mRNA localization" EXACT []
synonym: "downregulation of pole plasm oskar mRNA localization" EXACT []
synonym: "inhibition of pole plasm oskar mRNA localization" NARROW []
synonym: "negative regulation of oocyte pole plasm oskar mRNA localization" EXACT []
synonym: "negative regulation of pole plasm oskar mRNA localisation" EXACT [GOC:mah]
is_a: GO:0007317 ! regulation of pole plasm oskar mRNA localization
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:0060283 ! negative regulation of oocyte development
is_a: GO:1902876 ! negative regulation of embryonic pattern specification
is_a: GO:1903430 ! negative regulation of cell maturation
is_a: GO:1904581 ! negative regulation of intracellular mRNA localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045451 ! pole plasm oskar mRNA localization
relationship: negatively_regulates GO:0045451 ! pole plasm oskar mRNA localization

[Term]
id: GO:0045856
name: positive regulation of pole plasm oskar mRNA localization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators]
synonym: "activation of pole plasm oskar mRNA localization" NARROW []
synonym: "positive regulation of oocyte pole plasm oskar mRNA localization" EXACT []
synonym: "positive regulation of pole plasm oskar mRNA localisation" EXACT [GOC:mah]
synonym: "stimulation of pole plasm oskar mRNA localization" NARROW []
synonym: "up regulation of pole plasm oskar mRNA localization" EXACT []
synonym: "up-regulation of pole plasm oskar mRNA localization" EXACT []
synonym: "upregulation of pole plasm oskar mRNA localization" EXACT []
is_a: GO:0007317 ! regulation of pole plasm oskar mRNA localization
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:0060282 ! positive regulation of oocyte development
is_a: GO:1902877 ! positive regulation of embryonic pattern specification
is_a: GO:1903431 ! positive regulation of cell maturation
is_a: GO:1904582 ! positive regulation of intracellular mRNA localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045451 ! pole plasm oskar mRNA localization
relationship: positively_regulates GO:0045451 ! pole plasm oskar mRNA localization

[Term]
id: GO:0045857
name: negative regulation of molecular function, epigenetic
namespace: biological_process
def: "Any heritable epigenetic process that stops, prevents, or reduces the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich ('prion') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "down regulation of protein activity, epigenetic" EXACT []
synonym: "down-regulation of protein activity, epigenetic" EXACT []
synonym: "downregulation of protein activity, epigenetic" EXACT []
synonym: "inhibition of protein activity, epigenetic" NARROW []
synonym: "negative regulation of protein activity, epigenetic" EXACT [GOC:dph, GOC:tb]
is_a: GO:0040030 ! regulation of molecular function, epigenetic
is_a: GO:0044092 ! negative regulation of molecular function

[Term]
id: GO:0045858
name: positive regulation of molecular function, epigenetic
namespace: biological_process
def: "Any heritable epigenetic process that increases the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich ('prion') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "activation of protein activity, epigenetic" NARROW []
synonym: "positive regulation of protein activity, epigenetic" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of protein activity, epigenetic" NARROW []
synonym: "up regulation of protein activity, epigenetic" EXACT []
synonym: "up-regulation of protein activity, epigenetic" EXACT []
synonym: "upregulation of protein activity, epigenetic" EXACT []
is_a: GO:0040030 ! regulation of molecular function, epigenetic
is_a: GO:0044093 ! positive regulation of molecular function

[Term]
id: GO:0045859
name: regulation of protein kinase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein kinase activity." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0001932 ! regulation of protein phosphorylation
is_a: GO:0043549 ! regulation of kinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004672 ! protein kinase activity
relationship: regulates GO:0004672 ! protein kinase activity

[Term]
id: GO:0045860
name: positive regulation of protein kinase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein kinase activity." [GOC:go_curators]
subset: gosubset_prok
synonym: "stimulation of protein kinase activity" NARROW []
synonym: "up regulation of protein kinase activity" EXACT []
synonym: "up-regulation of protein kinase activity" EXACT []
synonym: "upregulation of protein kinase activity" EXACT []
is_a: GO:0001934 ! positive regulation of protein phosphorylation
is_a: GO:0033674 ! positive regulation of kinase activity
is_a: GO:0045859 ! regulation of protein kinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004672 ! protein kinase activity
relationship: positively_regulates GO:0004672 ! protein kinase activity

[Term]
id: GO:0045861
name: negative regulation of proteolysis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of proteolysis" EXACT []
synonym: "down-regulation of proteolysis" EXACT []
synonym: "downregulation of proteolysis" EXACT []
synonym: "inhibition of proteolysis" NARROW []
synonym: "negative regulation of peptidolysis" EXACT []
is_a: GO:0030162 ! regulation of proteolysis
is_a: GO:0032269 ! negative regulation of cellular protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006508 ! proteolysis
relationship: negatively_regulates GO:0006508 ! proteolysis

[Term]
id: GO:0045862
name: positive regulation of proteolysis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of proteolysis" NARROW []
synonym: "positive regulation of peptidolysis" EXACT []
synonym: "stimulation of proteolysis" NARROW []
synonym: "up regulation of proteolysis" EXACT []
synonym: "up-regulation of proteolysis" EXACT []
synonym: "upregulation of proteolysis" EXACT []
is_a: GO:0030162 ! regulation of proteolysis
is_a: GO:0032270 ! positive regulation of cellular protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006508 ! proteolysis
relationship: positively_regulates GO:0006508 ! proteolysis

[Term]
id: GO:0045863
name: negative regulation of pteridine metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving pteridine." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of pteridine metabolic process" EXACT []
synonym: "down-regulation of pteridine metabolic process" EXACT []
synonym: "downregulation of pteridine metabolic process" EXACT []
synonym: "inhibition of pteridine metabolic process" NARROW []
synonym: "negative regulation of pteridine metabolism" EXACT []
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0042068 ! regulation of pteridine metabolic process
is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019889 ! pteridine metabolic process
relationship: negatively_regulates GO:0019889 ! pteridine metabolic process

[Term]
id: GO:0045864
name: positive regulation of pteridine metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving pteridine." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of pteridine metabolic process" NARROW []
synonym: "positive regulation of pteridine metabolism" EXACT []
synonym: "stimulation of pteridine metabolic process" NARROW []
synonym: "up regulation of pteridine metabolic process" EXACT []
synonym: "up-regulation of pteridine metabolic process" EXACT []
synonym: "upregulation of pteridine metabolic process" EXACT []
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0042068 ! regulation of pteridine metabolic process
is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0019889 ! pteridine metabolic process
relationship: positively_regulates GO:0019889 ! pteridine metabolic process

[Term]
id: GO:0045865
name: obsolete regulation of recombination within rDNA repeats
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of genetic recombination within the DNA of the genes coding for ribosomal RNA." [GOC:go_curators, ISBN:0198506732]
comment: This term was made obsolete because it describes a substrate-specific process.
synonym: "regulation of recombination within rDNA repeats" EXACT []
is_obsolete: true
replaced_by: GO:0000019

[Term]
id: GO:0045866
name: obsolete positive regulation of recombination within rDNA repeats
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of genetic recombination within the DNA of the genes coding for ribosomal RNA." [GOC:go_curators, ISBN:0198506732]
comment: This term was made obsolete because it describes a substrate-specific process.
synonym: "positive regulation of recombination within rDNA repeats" EXACT []
is_obsolete: true
consider: GO:0045951

[Term]
id: GO:0045869
name: negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of single stranded viral RNA replication via double stranded DNA intermediate." [GOC:go_curators]
synonym: "down regulation of retroviral genome replication" EXACT []
synonym: "down-regulation of retroviral genome replication" EXACT []
synonym: "downregulation of retroviral genome replication" EXACT []
synonym: "inhibition of retroviral genome replication" NARROW []
synonym: "negative regulation of retroviral genome replication" EXACT [GOC:bf, GOC:jl]
synonym: "regulation of retroviral genome replication" RELATED []
is_a: GO:0045071 ! negative regulation of viral genome replication
is_a: GO:0045091 ! regulation of single stranded viral RNA replication via double stranded DNA intermediate
is_a: GO:0051053 ! negative regulation of DNA metabolic process
is_a: GO:0051253 ! negative regulation of RNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0039692 ! single stranded viral RNA replication via double stranded DNA intermediate
relationship: negatively_regulates GO:0039692 ! single stranded viral RNA replication via double stranded DNA intermediate

[Term]
id: GO:0045870
name: positive regulation of single stranded viral RNA replication via double stranded DNA intermediate
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of retroviral genome replication." [GOC:go_curators]
synonym: "activation of retroviral genome replication" NARROW []
synonym: "positive regulation of retroviral genome replication" EXACT [GOC:bf, GOC:jl]
synonym: "stimulation of retroviral genome replication" NARROW []
synonym: "up regulation of retroviral genome replication" EXACT []
synonym: "up-regulation of retroviral genome replication" EXACT []
synonym: "upregulation of retroviral genome replication" EXACT []
is_a: GO:0045070 ! positive regulation of viral genome replication
is_a: GO:0045091 ! regulation of single stranded viral RNA replication via double stranded DNA intermediate
is_a: GO:0051054 ! positive regulation of DNA metabolic process
is_a: GO:0051254 ! positive regulation of RNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0039692 ! single stranded viral RNA replication via double stranded DNA intermediate
relationship: positively_regulates GO:0039692 ! single stranded viral RNA replication via double stranded DNA intermediate

[Term]
id: GO:0045871
name: negative regulation of rhodopsin gene expression
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of rhodopsin gene expression." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "down regulation of rhodopsin gene activity" EXACT []
synonym: "down-regulation of rhodopsin gene activity" EXACT []
synonym: "downregulation of rhodopsin gene activity" EXACT []
synonym: "inhibition of rhodopsin gene activity" NARROW []
synonym: "negative regulation of rhodopsin gene activity" EXACT [GOC:dph, GOC:tb]
is_a: GO:0007468 ! regulation of rhodopsin gene expression
is_a: GO:0010629 ! negative regulation of gene expression

[Term]
id: GO:0045872
name: positive regulation of rhodopsin gene expression
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of rhodopsin gene expression." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "activation of rhodopsin gene activity" NARROW []
synonym: "positive regulation of rhodopsin gene activity" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of rhodopsin gene activity" NARROW []
synonym: "up regulation of rhodopsin gene activity" EXACT []
synonym: "up-regulation of rhodopsin gene activity" EXACT []
synonym: "upregulation of rhodopsin gene activity" EXACT []
is_a: GO:0007468 ! regulation of rhodopsin gene expression
is_a: GO:0010628 ! positive regulation of gene expression

[Term]
id: GO:0045873
name: negative regulation of sevenless signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the sevenless signaling pathway." [GOC:go_curators]
synonym: "down regulation of sevenless signaling pathway" EXACT []
synonym: "down-regulation of sevenless signaling pathway" EXACT []
synonym: "downregulation of sevenless signaling pathway" EXACT []
synonym: "inhibition of sevenless signaling pathway" NARROW []
synonym: "negative regulation of sev signaling pathway" EXACT []
synonym: "negative regulation of sevenless signalling pathway" EXACT []
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0010454 ! negative regulation of cell fate commitment
is_a: GO:0045501 ! regulation of sevenless signaling pathway
is_a: GO:0045677 ! negative regulation of R7 cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045500 ! sevenless signaling pathway
relationship: negatively_regulates GO:0045500 ! sevenless signaling pathway

[Term]
id: GO:0045874
name: positive regulation of sevenless signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the sevenless signaling pathway." [GOC:go_curators]
synonym: "activation of sevenless signaling pathway" NARROW []
synonym: "positive regulation of sev signaling pathway" EXACT []
synonym: "positive regulation of sevenless signalling pathway" EXACT []
synonym: "stimulation of sevenless signaling pathway" NARROW []
synonym: "up regulation of sevenless signaling pathway" EXACT []
synonym: "up-regulation of sevenless signaling pathway" EXACT []
synonym: "upregulation of sevenless signaling pathway" EXACT []
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0010455 ! positive regulation of cell fate commitment
is_a: GO:0045501 ! regulation of sevenless signaling pathway
is_a: GO:0045678 ! positive regulation of R7 cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045500 ! sevenless signaling pathway
relationship: positively_regulates GO:0045500 ! sevenless signaling pathway

[Term]
id: GO:0045875
name: negative regulation of sister chromatid cohesion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid cohesion." [GOC:go_curators]
synonym: "down regulation of sister chromatid cohesion" EXACT []
synonym: "down-regulation of sister chromatid cohesion" EXACT []
synonym: "downregulation of sister chromatid cohesion" EXACT []
synonym: "inhibition of sister chromatid cohesion" NARROW []
is_a: GO:0007063 ! regulation of sister chromatid cohesion
is_a: GO:0033046 ! negative regulation of sister chromatid segregation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007062 ! sister chromatid cohesion
relationship: negatively_regulates GO:0007062 ! sister chromatid cohesion

[Term]
id: GO:0045876
name: positive regulation of sister chromatid cohesion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sister chromatid cohesion." [GOC:go_curators]
synonym: "activation of sister chromatid cohesion" NARROW []
synonym: "stimulation of sister chromatid cohesion" NARROW []
synonym: "up regulation of sister chromatid cohesion" EXACT []
synonym: "up-regulation of sister chromatid cohesion" EXACT []
synonym: "upregulation of sister chromatid cohesion" EXACT []
is_a: GO:0007063 ! regulation of sister chromatid cohesion
is_a: GO:0051984 ! positive regulation of chromosome segregation
is_a: GO:0090068 ! positive regulation of cell cycle process
is_a: GO:2001252 ! positive regulation of chromosome organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007062 ! sister chromatid cohesion
relationship: positively_regulates GO:0007062 ! sister chromatid cohesion

[Term]
id: GO:0045879
name: negative regulation of smoothened signaling pathway
namespace: biological_process
alt_id: GO:0045877
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling." [GOC:go_curators]
synonym: "down regulation of smoothened signaling pathway" EXACT []
synonym: "down-regulation of smoothened signaling pathway" EXACT []
synonym: "downregulation of smoothened signaling pathway" EXACT []
synonym: "inhibition of smoothened signaling pathway" NARROW []
synonym: "negative regulation of hedgehog signaling pathway" EXACT [GOC:bf, GOC:ecd]
synonym: "negative regulation of hh signaling pathway" EXACT [GOC:bf, GOC:ecd]
synonym: "negative regulation of smoothened activity" RELATED []
synonym: "negative regulation of smoothened by patched" NARROW []
synonym: "negative regulation of smoothened receptor activity by patched" RELATED []
synonym: "negative regulation of smoothened signalling pathway" EXACT []
is_a: GO:0008589 ! regulation of smoothened signaling pathway
is_a: GO:0009968 ! negative regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007224 ! smoothened signaling pathway
relationship: negatively_regulates GO:0007224 ! smoothened signaling pathway

[Term]
id: GO:0045880
name: positive regulation of smoothened signaling pathway
namespace: biological_process
alt_id: GO:0045878
def: "Any process that activates or increases the frequency, rate or extent of smoothened signaling." [GOC:go_curators]
synonym: "activation of smoothened signaling pathway" NARROW []
synonym: "positive regulation of hedgehog signaling pathway" EXACT [GOC:bf, GOC:ecd]
synonym: "positive regulation of hh signaling pathway" EXACT [GOC:bf, GOC:ecd]
synonym: "positive regulation of smoothened by patched" RELATED []
synonym: "positive regulation of smoothened receptor activity by patched" RELATED []
synonym: "positive regulation of smoothened signalling pathway" EXACT []
synonym: "stimulation of smoothened signaling pathway" NARROW []
synonym: "up regulation of smoothened signaling pathway" EXACT []
synonym: "up-regulation of smoothened signaling pathway" EXACT []
synonym: "upregulation of smoothened signaling pathway" EXACT []
is_a: GO:0008589 ! regulation of smoothened signaling pathway
is_a: GO:0009967 ! positive regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007224 ! smoothened signaling pathway
relationship: positively_regulates GO:0007224 ! smoothened signaling pathway

[Term]
id: GO:0045881
name: positive regulation of sporulation resulting in formation of a cellular spore
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sporulation." [GOC:go_curators]
synonym: "activation of sporulation" NARROW []
synonym: "stimulation of sporulation" NARROW []
synonym: "up regulation of sporulation" EXACT []
synonym: "up-regulation of sporulation" EXACT []
synonym: "upregulation of sporulation" EXACT []
is_a: GO:0042173 ! regulation of sporulation resulting in formation of a cellular spore
is_a: GO:0043938 ! positive regulation of sporulation
is_a: GO:0045597 ! positive regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030435 ! sporulation resulting in formation of a cellular spore
relationship: positively_regulates GO:0030435 ! sporulation resulting in formation of a cellular spore

[Term]
id: GO:0045882
name: negative regulation of sulfur utilization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sulfur utilization." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of sulfur utilization" EXACT []
synonym: "down-regulation of sulfur utilization" EXACT []
synonym: "downregulation of sulfur utilization" EXACT []
synonym: "inhibition of sulfur utilization" NARROW []
synonym: "negative regulation of sulphur utilization" EXACT []
is_a: GO:0006792 ! regulation of sulfur utilization
is_a: GO:0048519 ! negative regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006791 ! sulfur utilization
relationship: negatively_regulates GO:0006791 ! sulfur utilization

[Term]
id: GO:0045883
name: positive regulation of sulfur utilization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sulfur utilization." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of sulfur utilization" NARROW []
synonym: "positive regulation of sulphur utilization" EXACT []
synonym: "stimulation of sulfur utilization" NARROW []
synonym: "up regulation of sulfur utilization" EXACT []
synonym: "up-regulation of sulfur utilization" EXACT []
synonym: "upregulation of sulfur utilization" EXACT []
is_a: GO:0006792 ! regulation of sulfur utilization
is_a: GO:0048518 ! positive regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006791 ! sulfur utilization
relationship: positively_regulates GO:0006791 ! sulfur utilization

[Term]
id: GO:0045884
name: obsolete regulation of survival gene product expression
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of survival gene product expression; survival gene products are those that antagonize the apoptotic program. Regulation can be at the transcriptional, translational, or posttranslational level." [GOC:dph, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb]
comment: This term was made obsolete because the meaning of the term is ambiguous: the same gene product may or may not have a role in apoptosis depending on the cell type, tissue type, condition, etc.
synonym: "regulation of survival gene product activity" BROAD [GOC:dph, GOC:tb]
synonym: "regulation of survival gene product expression" EXACT []
synonym: "regulation of survival gene products" BROAD []
is_obsolete: true

[Term]
id: GO:0045885
name: obsolete positive regulation of survival gene product expression
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of survival gene product expression; survival gene products are those that antagonize the apoptotic program. Regulation can be at the transcriptional, translational, or posttranslational level." [GOC:dph, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb]
comment: This term was made obsolete because the meaning of the term is ambiguous: the same gene product may or may not have a role in apoptosis depending on the cell type, tissue type, condition, etc.
synonym: "activation of survival gene product activity" BROAD []
synonym: "positive regulation of survival gene product activity" BROAD [GOC:dph, GOC:tb]
synonym: "positive regulation of survival gene product expression" EXACT []
synonym: "positive regulation of survival gene products" BROAD []
synonym: "stimulation of survival gene product activity" NARROW []
synonym: "up regulation of survival gene product activity" BROAD []
synonym: "up-regulation of survival gene product activity" BROAD []
synonym: "upregulation of survival gene product activity" BROAD []
is_obsolete: true

[Term]
id: GO:0045886
name: negative regulation of synaptic growth at neuromuscular junction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators]
synonym: "down regulation of synaptic growth at neuromuscular junction" EXACT []
synonym: "down-regulation of synaptic growth at neuromuscular junction" EXACT []
synonym: "downregulation of synaptic growth at neuromuscular junction" EXACT []
synonym: "inhibition of synaptic growth at neuromuscular junction" NARROW []
is_a: GO:0008582 ! regulation of synaptic growth at neuromuscular junction
is_a: GO:0048640 ! negative regulation of developmental growth
is_a: GO:0051964 ! negative regulation of synapse assembly
is_a: GO:1904397 ! negative regulation of neuromuscular junction development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051124 ! synaptic growth at neuromuscular junction
relationship: negatively_regulates GO:0051124 ! synaptic growth at neuromuscular junction

[Term]
id: GO:0045887
name: positive regulation of synaptic growth at neuromuscular junction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators]
synonym: "activation of synaptic growth at neuromuscular junction" NARROW []
synonym: "stimulation of synaptic growth at neuromuscular junction" NARROW []
synonym: "up regulation of synaptic growth at neuromuscular junction" EXACT []
synonym: "up-regulation of synaptic growth at neuromuscular junction" EXACT []
synonym: "upregulation of synaptic growth at neuromuscular junction" EXACT []
is_a: GO:0008582 ! regulation of synaptic growth at neuromuscular junction
is_a: GO:0048639 ! positive regulation of developmental growth
is_a: GO:0051965 ! positive regulation of synapse assembly
is_a: GO:1904398 ! positive regulation of neuromuscular junction development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051124 ! synaptic growth at neuromuscular junction
relationship: positively_regulates GO:0051124 ! synaptic growth at neuromuscular junction

[Term]
id: GO:0045888
name: obsolete regulation of transcription of homeotic gene (Polycomb group)
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription of homeotic genes of the Polycomb group." [GOC:go_curators]
comment: This term was made obsolete because it relates to a specific gene family rather than a process.
synonym: "regulation of transcription of homeotic gene (Polycomb group)" EXACT []
is_obsolete: true
consider: GO:0006342
consider: GO:0048096

[Term]
id: GO:0045889
name: obsolete positive regulation of transcription of homeotic gene (Polycomb group)
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription of homeotic genes of the Polycomb group." [GOC:go_curators]
comment: This term was made obsolete because it relates to a specific gene family rather than a process.
synonym: "positive regulation of transcription of homeotic gene (Polycomb group)" EXACT []
is_obsolete: true
consider: GO:0006342
consider: GO:0048096

[Term]
id: GO:0045890
name: obsolete regulation of transcription of homeotic gene (trithorax group)
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription of homeotic genes of the trithorax group." [GOC:go_curators]
comment: This term was made obsolete because it relates to a specific gene family rather than a process.
synonym: "regulation of transcription of homeotic gene (trithorax group)" EXACT []
is_obsolete: true
consider: GO:0006342
consider: GO:0048096

[Term]
id: GO:0045891
name: obsolete negative regulation of transcription of homeotic gene (trithorax group)
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription of homeotic genes of the trithorax group." [GOC:go_curators]
comment: This term was made obsolete because it relates to a specific gene family rather than a process.
synonym: "negative regulation of transcription of homeotic gene (trithorax group)" EXACT []
is_obsolete: true
consider: GO:0006342
consider: GO:0048096

[Term]
id: GO:0045892
name: negative regulation of transcription, DNA-templated
namespace: biological_process
alt_id: GO:0016481
alt_id: GO:0032582
alt_id: GO:0061021
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
subset: gosubset_prok
synonym: "down regulation of gene-specific transcription" RELATED []
synonym: "down regulation of transcription, DNA-dependent" EXACT []
synonym: "down-regulation of gene-specific transcription" RELATED []
synonym: "down-regulation of transcription, DNA-dependent" EXACT []
synonym: "downregulation of gene-specific transcription" RELATED []
synonym: "downregulation of transcription, DNA-dependent" EXACT []
synonym: "inhibition of gene-specific transcription" RELATED []
synonym: "inhibition of transcription, DNA-dependent" NARROW []
synonym: "negative regulation of cellular transcription, DNA-dependent" EXACT []
synonym: "negative regulation of gene-specific transcription" RELATED []
synonym: "negative regulation of transcription, DNA-dependent" EXACT [GOC:txnOH]
synonym: "transcription repressor activity" RELATED []
is_a: GO:0006355 ! regulation of transcription, DNA-templated
is_a: GO:0010629 ! negative regulation of gene expression
is_a: GO:1903507 ! negative regulation of nucleic acid-templated transcription
is_a: GO:2000113 ! negative regulation of cellular macromolecule biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006351 ! transcription, DNA-templated
relationship: negatively_regulates GO:0006351 ! transcription, DNA-templated

[Term]
id: GO:0045893
name: positive regulation of transcription, DNA-templated
namespace: biological_process
alt_id: GO:0043193
alt_id: GO:0045941
alt_id: GO:0061020
def: "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
subset: gosubset_prok
synonym: "activation of gene-specific transcription" RELATED []
synonym: "activation of transcription, DNA-dependent" NARROW []
synonym: "positive regulation of cellular transcription, DNA-dependent" EXACT []
synonym: "positive regulation of gene-specific transcription" RELATED []
synonym: "positive regulation of transcription, DNA-dependent" EXACT [GOC:txnOH]
synonym: "stimulation of gene-specific transcription" NARROW []
synonym: "stimulation of transcription, DNA-dependent" NARROW []
synonym: "transcription activator activity" RELATED []
synonym: "up regulation of gene-specific transcription" RELATED []
synonym: "up regulation of transcription, DNA-dependent" EXACT []
synonym: "up-regulation of gene-specific transcription" RELATED []
synonym: "up-regulation of transcription, DNA-dependent" EXACT []
synonym: "upregulation of gene-specific transcription" RELATED []
synonym: "upregulation of transcription, DNA-dependent" EXACT []
is_a: GO:0006355 ! regulation of transcription, DNA-templated
is_a: GO:0010628 ! positive regulation of gene expression
is_a: GO:1903508 ! positive regulation of nucleic acid-templated transcription
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006351 ! transcription, DNA-templated
relationship: positively_regulates GO:0006351 ! transcription, DNA-templated

[Term]
id: GO:0045894
name: negative regulation of mating-type specific transcription, DNA-templated
namespace: biological_process
def: "Any mating-type specific process that stops, prevents or reduces the rate of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
synonym: "down regulation of transcription, mating-type specific" EXACT []
synonym: "down-regulation of transcription, mating-type specific" EXACT []
synonym: "downregulation of transcription, mating-type specific" EXACT []
synonym: "inhibition of transcription, mating-type specific" NARROW []
synonym: "negative regulation of mating-type specific transcription, DNA-dependent" EXACT [GOC:txnOH]
is_a: GO:0007532 ! regulation of mating-type specific transcription, DNA-templated
is_a: GO:0045892 ! negative regulation of transcription, DNA-templated

[Term]
id: GO:0045895
name: positive regulation of mating-type specific transcription, DNA-templated
namespace: biological_process
def: "Any mating-type specific process that activates or increases the rate of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
synonym: "activation of transcription, mating-type specific" NARROW []
synonym: "positive regulation of mating-type specific transcription, DNA-dependent" EXACT [GOC:txnOH]
synonym: "stimulation of transcription, mating-type specific" NARROW []
synonym: "up regulation of transcription, mating-type specific" EXACT []
synonym: "up-regulation of transcription, mating-type specific" EXACT []
synonym: "upregulation of transcription, mating-type specific" EXACT []
is_a: GO:0007532 ! regulation of mating-type specific transcription, DNA-templated
is_a: GO:0045893 ! positive regulation of transcription, DNA-templated

[Term]
id: GO:0045896
name: regulation of transcription during mitosis
namespace: biological_process
def: "A cell cycle process that modulates the frequency, rate or extent of transcription during mitosis." [GOC:go_curators]
synonym: "mitotic regulation of transcription" EXACT []
synonym: "regulation of transcription, mitotic" EXACT [GOC:mah]
is_a: GO:0006355 ! regulation of transcription, DNA-templated
intersection_of: GO:0006355 ! regulation of transcription, DNA-templated
intersection_of: part_of GO:0007067 ! mitotic nuclear division
relationship: part_of GO:0007067 ! mitotic nuclear division

[Term]
id: GO:0045897
name: positive regulation of transcription during mitosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transcription during mitosis." [GOC:go_curators]
synonym: "activation of transcription during mitosis" NARROW [GOC:mah]
synonym: "mitotic activation of transcription" EXACT []
synonym: "positive regulation of transcription, mitotic" EXACT [GOC:mah]
synonym: "stimulation of transcription during mitosis" NARROW [GOC:mah]
synonym: "up regulation of transcription during mitosis" EXACT [GOC:mah]
synonym: "up-regulation of transcription during mitosis" EXACT [GOC:mah]
synonym: "upregulation of transcription during mitosis" EXACT [GOC:mah]
is_a: GO:0045893 ! positive regulation of transcription, DNA-templated
is_a: GO:0045896 ! regulation of transcription during mitosis
intersection_of: GO:0045893 ! positive regulation of transcription, DNA-templated
intersection_of: part_of GO:0007067 ! mitotic nuclear division
relationship: part_of GO:0007067 ! mitotic nuclear division

[Term]
id: GO:0045898
name: regulation of RNA polymerase II transcriptional preinitiation complex assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly." [GOC:go_curators]
synonym: "regulation of RNA polymerase II transcriptional pre-initiation complex assembly" EXACT []
synonym: "regulation of RNA polymerase II transcriptional pre-initiation complex biosynthesis" EXACT []
synonym: "regulation of RNA polymerase II transcriptional preinitiation complex formation" RELATED []
is_a: GO:0060260 ! regulation of transcription initiation from RNA polymerase II promoter
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051123 ! RNA polymerase II transcriptional preinitiation complex assembly
relationship: regulates GO:0051123 ! RNA polymerase II transcriptional preinitiation complex assembly

[Term]
id: GO:0045899
name: positive regulation of RNA polymerase II transcriptional preinitiation complex assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly." [GOC:go_curators]
synonym: "activation of RNA polymerase II transcriptional preinitiation complex assembly" NARROW []
synonym: "positive regulation of RNA polymerase II transcriptional pre-initiation complex assembly" EXACT []
synonym: "positive regulation of RNA polymerase II transcriptional pre-initiation complex biosynthesis" EXACT []
synonym: "positive regulation of RNA polymerase II transcriptional preinitiation complex formation" EXACT []
synonym: "stimulation of RNA polymerase II transcriptional preinitiation complex assembly" NARROW []
synonym: "up regulation of RNA polymerase II transcriptional preinitiation complex assembly" EXACT []
synonym: "up-regulation of RNA polymerase II transcriptional preinitiation complex assembly" EXACT []
synonym: "upregulation of RNA polymerase II transcriptional preinitiation complex assembly" EXACT []
is_a: GO:0045898 ! regulation of RNA polymerase II transcriptional preinitiation complex assembly
is_a: GO:0060261 ! positive regulation of transcription initiation from RNA polymerase II promoter
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051123 ! RNA polymerase II transcriptional preinitiation complex assembly
relationship: positively_regulates GO:0051123 ! RNA polymerase II transcriptional preinitiation complex assembly

[Term]
id: GO:0045900
name: negative regulation of translational elongation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of translational elongation" EXACT []
synonym: "down-regulation of translational elongation" EXACT []
synonym: "downregulation of translational elongation" EXACT []
synonym: "inhibition of translational elongation" NARROW []
is_a: GO:0006448 ! regulation of translational elongation
is_a: GO:0017148 ! negative regulation of translation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006414 ! translational elongation
relationship: negatively_regulates GO:0006414 ! translational elongation

[Term]
id: GO:0045901
name: positive regulation of translational elongation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of translational elongation." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of translational elongation" NARROW []
synonym: "stimulation of translational elongation" NARROW []
synonym: "up regulation of translational elongation" EXACT []
synonym: "up-regulation of translational elongation" EXACT []
synonym: "upregulation of translational elongation" EXACT []
is_a: GO:0006448 ! regulation of translational elongation
is_a: GO:0045727 ! positive regulation of translation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006414 ! translational elongation
relationship: positively_regulates GO:0006414 ! translational elongation

[Term]
id: GO:0045902
name: negative regulation of translational fidelity
namespace: biological_process
def: "Any process that decreases the ability of the translational apparatus to interpret the genetic code." [GOC:dph, GOC:tb]
subset: gosubset_prok
synonym: "down regulation of translational fidelity" EXACT []
synonym: "down-regulation of translational fidelity" EXACT []
synonym: "downregulation of translational fidelity" EXACT []
synonym: "inhibition of translational fidelity" NARROW []
is_a: GO:0006450 ! regulation of translational fidelity
is_a: GO:0017148 ! negative regulation of translation

[Term]
id: GO:0045903
name: positive regulation of translational fidelity
namespace: biological_process
def: "Any process that increases the ability of the translational apparatus to interpret the genetic code." [GOC:dph, GOC:tb]
subset: gosubset_prok
synonym: "activation of translational fidelity" NARROW []
synonym: "stimulation of translational fidelity" NARROW []
synonym: "up regulation of translational fidelity" EXACT []
synonym: "up-regulation of translational fidelity" EXACT []
synonym: "upregulation of translational fidelity" EXACT []
is_a: GO:0006450 ! regulation of translational fidelity
is_a: GO:0045727 ! positive regulation of translation

[Term]
id: GO:0045904
name: negative regulation of translational termination
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of translational termination." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of translational termination" EXACT []
synonym: "down-regulation of translational termination" EXACT []
synonym: "downregulation of translational termination" EXACT []
synonym: "inhibition of translational termination" NARROW []
is_a: GO:0006449 ! regulation of translational termination
is_a: GO:0017148 ! negative regulation of translation
is_a: GO:0043242 ! negative regulation of protein complex disassembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006415 ! translational termination
relationship: negatively_regulates GO:0006415 ! translational termination

[Term]
id: GO:0045905
name: positive regulation of translational termination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of translational termination." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of translational termination" NARROW []
synonym: "stimulation of translational termination" NARROW []
synonym: "up regulation of translational termination" EXACT []
synonym: "up-regulation of translational termination" EXACT []
synonym: "upregulation of translational termination" EXACT []
is_a: GO:0006449 ! regulation of translational termination
is_a: GO:0043243 ! positive regulation of protein complex disassembly
is_a: GO:0045727 ! positive regulation of translation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006415 ! translational termination
relationship: positively_regulates GO:0006415 ! translational termination

[Term]
id: GO:0045906
name: negative regulation of vasoconstriction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of vasoconstriction." [GOC:go_curators]
synonym: "down regulation of vasoconstriction" EXACT []
synonym: "down-regulation of vasoconstriction" EXACT []
synonym: "downregulation of vasoconstriction" EXACT []
synonym: "inhibition of vasoconstriction" NARROW []
is_a: GO:0019229 ! regulation of vasoconstriction
is_a: GO:1903523 ! negative regulation of blood circulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042310 ! vasoconstriction
relationship: negatively_regulates GO:0042310 ! vasoconstriction

[Term]
id: GO:0045907
name: positive regulation of vasoconstriction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vasoconstriction." [GOC:go_curators]
synonym: "activation of vasoconstriction" NARROW []
synonym: "stimulation of vasoconstriction" NARROW []
synonym: "up regulation of vasoconstriction" EXACT []
synonym: "up-regulation of vasoconstriction" EXACT []
synonym: "upregulation of vasoconstriction" EXACT []
is_a: GO:0019229 ! regulation of vasoconstriction
is_a: GO:1903524 ! positive regulation of blood circulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042310 ! vasoconstriction
relationship: positively_regulates GO:0042310 ! vasoconstriction

[Term]
id: GO:0045908
name: negative regulation of vasodilation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of vasodilation." [GOC:go_curators]
synonym: "down regulation of vasodilation" EXACT []
synonym: "down-regulation of vasodilation" EXACT []
synonym: "downregulation of vasodilation" EXACT []
synonym: "inhibition of vasodilation" NARROW []
is_a: GO:0042312 ! regulation of vasodilation
is_a: GO:1903523 ! negative regulation of blood circulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042311 ! vasodilation
relationship: negatively_regulates GO:0042311 ! vasodilation

[Term]
id: GO:0045909
name: positive regulation of vasodilation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vasodilation." [GOC:go_curators]
synonym: "activation of vasodilation" NARROW []
synonym: "stimulation of vasodilation" NARROW []
synonym: "up regulation of vasodilation" EXACT []
synonym: "up-regulation of vasodilation" EXACT []
synonym: "upregulation of vasodilation" EXACT []
is_a: GO:0042312 ! regulation of vasodilation
is_a: GO:1903524 ! positive regulation of blood circulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042311 ! vasodilation
relationship: positively_regulates GO:0042311 ! vasodilation

[Term]
id: GO:0045910
name: negative regulation of DNA recombination
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of DNA recombination" EXACT []
synonym: "down-regulation of DNA recombination" EXACT []
synonym: "downregulation of DNA recombination" EXACT []
synonym: "inhibition of DNA recombination" NARROW []
is_a: GO:0000018 ! regulation of DNA recombination
is_a: GO:0051053 ! negative regulation of DNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006310 ! DNA recombination
relationship: negatively_regulates GO:0006310 ! DNA recombination

[Term]
id: GO:0045911
name: positive regulation of DNA recombination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA recombination." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of DNA recombination" NARROW []
synonym: "stimulation of DNA recombination" NARROW []
synonym: "up regulation of DNA recombination" EXACT []
synonym: "up-regulation of DNA recombination" EXACT []
synonym: "upregulation of DNA recombination" EXACT []
is_a: GO:0000018 ! regulation of DNA recombination
is_a: GO:0051054 ! positive regulation of DNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006310 ! DNA recombination
relationship: positively_regulates GO:0006310 ! DNA recombination

[Term]
id: GO:0045912
name: negative regulation of carbohydrate metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of carbohydrate metabolic process" EXACT []
synonym: "down-regulation of carbohydrate metabolic process" EXACT []
synonym: "downregulation of carbohydrate metabolic process" EXACT []
synonym: "inhibition of carbohydrate metabolic process" NARROW []
synonym: "negative regulation of carbohydrate metabolism" EXACT []
is_a: GO:0006109 ! regulation of carbohydrate metabolic process
is_a: GO:0009892 ! negative regulation of metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0005975 ! carbohydrate metabolic process
relationship: negatively_regulates GO:0005975 ! carbohydrate metabolic process

[Term]
id: GO:0045913
name: positive regulation of carbohydrate metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of carbohydrate metabolic process" NARROW []
synonym: "positive regulation of carbohydrate metabolism" EXACT []
synonym: "stimulation of carbohydrate metabolic process" NARROW []
synonym: "up regulation of carbohydrate metabolic process" EXACT []
synonym: "up-regulation of carbohydrate metabolic process" EXACT []
synonym: "upregulation of carbohydrate metabolic process" EXACT []
is_a: GO:0006109 ! regulation of carbohydrate metabolic process
is_a: GO:0009893 ! positive regulation of metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0005975 ! carbohydrate metabolic process
relationship: positively_regulates GO:0005975 ! carbohydrate metabolic process

[Term]
id: GO:0045914
name: negative regulation of catecholamine metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving catecholamine." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of catecholamine metabolic process" EXACT []
synonym: "down-regulation of catecholamine metabolic process" EXACT []
synonym: "downregulation of catecholamine metabolic process" EXACT []
synonym: "inhibition of catecholamine metabolic process" NARROW []
synonym: "negative regulation of catecholamine metabolism" EXACT []
is_a: GO:0033239 ! negative regulation of cellular amine metabolic process
is_a: GO:0042069 ! regulation of catecholamine metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006584 ! catecholamine metabolic process
relationship: negatively_regulates GO:0006584 ! catecholamine metabolic process

[Term]
id: GO:0045915
name: positive regulation of catecholamine metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catecholamine." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of catecholamine metabolic process" NARROW []
synonym: "positive regulation of catecholamine metabolism" EXACT []
synonym: "stimulation of catecholamine metabolic process" NARROW []
synonym: "up regulation of catecholamine metabolic process" EXACT []
synonym: "up-regulation of catecholamine metabolic process" EXACT []
synonym: "upregulation of catecholamine metabolic process" EXACT []
is_a: GO:0033240 ! positive regulation of cellular amine metabolic process
is_a: GO:0042069 ! regulation of catecholamine metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006584 ! catecholamine metabolic process
relationship: positively_regulates GO:0006584 ! catecholamine metabolic process

[Term]
id: GO:0045916
name: negative regulation of complement activation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation." [GOC:go_curators]
synonym: "down regulation of complement activation" EXACT []
synonym: "down-regulation of complement activation" EXACT []
synonym: "downregulation of complement activation" EXACT []
synonym: "inhibition of complement activation" NARROW []
synonym: "negative regulation of complement cascade" EXACT [GOC:add]
is_a: GO:0002698 ! negative regulation of immune effector process
is_a: GO:0002921 ! negative regulation of humoral immune response
is_a: GO:0010955 ! negative regulation of protein processing
is_a: GO:0030449 ! regulation of complement activation
is_a: GO:2000258 ! negative regulation of protein activation cascade
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006956 ! complement activation
relationship: negatively_regulates GO:0006956 ! complement activation

[Term]
id: GO:0045917
name: positive regulation of complement activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of complement activation." [GOC:go_curators]
synonym: "activation of complement activation" NARROW []
synonym: "positive regulation of complement cascade" EXACT [GOC:add]
synonym: "stimulation of complement activation" NARROW []
synonym: "up regulation of complement activation" EXACT []
synonym: "up-regulation of complement activation" EXACT []
synonym: "upregulation of complement activation" EXACT []
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0002922 ! positive regulation of humoral immune response
is_a: GO:0010954 ! positive regulation of protein processing
is_a: GO:0030449 ! regulation of complement activation
is_a: GO:2000259 ! positive regulation of protein activation cascade
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006956 ! complement activation
relationship: positively_regulates GO:0006956 ! complement activation

[Term]
id: GO:0045918
name: negative regulation of cytolysis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cytolysis." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of cytolysis" EXACT []
synonym: "down-regulation of cytolysis" EXACT []
synonym: "downregulation of cytolysis" EXACT []
synonym: "inhibition of cytolysis" NARROW []
is_a: GO:0042268 ! regulation of cytolysis
is_a: GO:0060548 ! negative regulation of cell death
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019835 ! cytolysis
relationship: negatively_regulates GO:0019835 ! cytolysis

[Term]
id: GO:0045919
name: positive regulation of cytolysis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cytolysis." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of cytolysis" NARROW []
synonym: "stimulation of cytolysis" NARROW []
synonym: "up regulation of cytolysis" EXACT []
synonym: "up-regulation of cytolysis" EXACT []
synonym: "upregulation of cytolysis" EXACT []
is_a: GO:0010942 ! positive regulation of cell death
is_a: GO:0042268 ! regulation of cytolysis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0019835 ! cytolysis
relationship: positively_regulates GO:0019835 ! cytolysis

[Term]
id: GO:0045920
name: negative regulation of exocytosis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis." [GOC:go_curators]
synonym: "down regulation of exocytosis" EXACT []
synonym: "down-regulation of exocytosis" EXACT []
synonym: "downregulation of exocytosis" EXACT []
synonym: "inhibition of exocytosis" NARROW []
is_a: GO:0017157 ! regulation of exocytosis
is_a: GO:1903531 ! negative regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006887 ! exocytosis
relationship: negatively_regulates GO:0006887 ! exocytosis

[Term]
id: GO:0045921
name: positive regulation of exocytosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of exocytosis." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of exocytosis" NARROW []
synonym: "stimulation of exocytosis" NARROW []
synonym: "up regulation of exocytosis" EXACT []
synonym: "up-regulation of exocytosis" EXACT []
synonym: "upregulation of exocytosis" EXACT []
is_a: GO:0017157 ! regulation of exocytosis
is_a: GO:1903532 ! positive regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006887 ! exocytosis
relationship: positively_regulates GO:0006887 ! exocytosis

[Term]
id: GO:0045922
name: negative regulation of fatty acid metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving fatty acids." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of fatty acid metabolic process" EXACT []
synonym: "down-regulation of fatty acid metabolic process" EXACT []
synonym: "downregulation of fatty acid metabolic process" EXACT []
synonym: "inhibition of fatty acid metabolic process" NARROW []
synonym: "negative regulation of fatty acid metabolism" EXACT []
is_a: GO:0019217 ! regulation of fatty acid metabolic process
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0045833 ! negative regulation of lipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006631 ! fatty acid metabolic process
relationship: negatively_regulates GO:0006631 ! fatty acid metabolic process

[Term]
id: GO:0045923
name: positive regulation of fatty acid metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving fatty acids." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of fatty acid metabolic process" NARROW []
synonym: "positive regulation of fatty acid metabolism" EXACT []
synonym: "stimulation of fatty acid metabolic process" NARROW []
synonym: "up regulation of fatty acid metabolic process" EXACT []
synonym: "up-regulation of fatty acid metabolic process" EXACT []
synonym: "upregulation of fatty acid metabolic process" EXACT []
is_a: GO:0019217 ! regulation of fatty acid metabolic process
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0045834 ! positive regulation of lipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006631 ! fatty acid metabolic process
relationship: positively_regulates GO:0006631 ! fatty acid metabolic process

[Term]
id: GO:0045924
name: regulation of female receptivity
namespace: biological_process
alt_id: GO:0060181
def: "Any process that modulates the frequency, rate or extent of the willingness or readiness of a female to receive male advances." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "female receptivity" RELATED [GOC:dph, GOC:tb]
is_a: GO:0060180 ! female mating behavior
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0045925
name: positive regulation of female receptivity
namespace: biological_process
def: "Any process that activates or increases the receptiveness of a female to male advances." [GOC:go_curators]
synonym: "activation of female receptivity" NARROW []
synonym: "stimulation of female receptivity" NARROW []
synonym: "up regulation of female receptivity" EXACT []
synonym: "up-regulation of female receptivity" EXACT []
synonym: "upregulation of female receptivity" EXACT []
is_a: GO:0045924 ! regulation of female receptivity

[Term]
id: GO:0045926
name: negative regulation of growth
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of growth" EXACT []
synonym: "down-regulation of growth" EXACT []
synonym: "downregulation of growth" EXACT []
synonym: "inhibition of growth" NARROW []
is_a: GO:0040008 ! regulation of growth
is_a: GO:0048519 ! negative regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0040007 ! growth
relationship: negatively_regulates GO:0040007 ! growth

[Term]
id: GO:0045927
name: positive regulation of growth
namespace: biological_process
def: "Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of growth" NARROW []
synonym: "stimulation of growth" NARROW []
synonym: "up regulation of growth" EXACT []
synonym: "up-regulation of growth" EXACT []
synonym: "upregulation of growth" EXACT []
is_a: GO:0040008 ! regulation of growth
is_a: GO:0048518 ! positive regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0040007 ! growth
relationship: positively_regulates GO:0040007 ! growth

[Term]
id: GO:0045928
name: negative regulation of juvenile hormone metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving juvenile hormone." [GOC:go_curators]
synonym: "down regulation of juvenile hormone metabolic process" EXACT []
synonym: "down-regulation of juvenile hormone metabolic process" EXACT []
synonym: "downregulation of juvenile hormone metabolic process" EXACT []
synonym: "inhibition of juvenile hormone metabolic process" NARROW []
synonym: "negative regulation of juvenile hormone metabolism" EXACT []
is_a: GO:0007556 ! regulation of juvenile hormone metabolic process
is_a: GO:0032351 ! negative regulation of hormone metabolic process
is_a: GO:0045827 ! negative regulation of isoprenoid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006716 ! juvenile hormone metabolic process
relationship: negatively_regulates GO:0006716 ! juvenile hormone metabolic process

[Term]
id: GO:0045929
name: positive regulation of juvenile hormone metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving juvenile hormone." [GOC:go_curators]
synonym: "activation of juvenile hormone metabolic process" NARROW []
synonym: "positive regulation of juvenile hormone metabolism" EXACT []
synonym: "stimulation of juvenile hormone metabolic process" NARROW []
synonym: "up regulation of juvenile hormone metabolic process" EXACT []
synonym: "up-regulation of juvenile hormone metabolic process" EXACT []
synonym: "upregulation of juvenile hormone metabolic process" EXACT []
is_a: GO:0007556 ! regulation of juvenile hormone metabolic process
is_a: GO:0032352 ! positive regulation of hormone metabolic process
is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006716 ! juvenile hormone metabolic process
relationship: positively_regulates GO:0006716 ! juvenile hormone metabolic process

[Term]
id: GO:0045930
name: negative regulation of mitotic cell cycle
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "down regulation of progression through mitotic cell cycle" EXACT []
synonym: "down-regulation of progression through mitotic cell cycle" EXACT []
synonym: "downregulation of progression through mitotic cell cycle" EXACT []
synonym: "inhibition of progression through mitotic cell cycle" NARROW []
synonym: "negative regulation of mitotic cell cycle progression" EXACT []
synonym: "negative regulation of progression through mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
is_a: GO:0007346 ! regulation of mitotic cell cycle
is_a: GO:0045786 ! negative regulation of cell cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000278 ! mitotic cell cycle
relationship: negatively_regulates GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0045931
name: positive regulation of mitotic cell cycle
namespace: biological_process
def: "Any process that activates or increases the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "activation of progression through mitotic cell cycle" NARROW []
synonym: "positive regulation of mitotic cell cycle progression" EXACT []
synonym: "positive regulation of progression through mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of progression through mitotic cell cycle" NARROW []
synonym: "up regulation of progression through mitotic cell cycle" EXACT []
synonym: "up-regulation of progression through mitotic cell cycle" EXACT []
synonym: "upregulation of progression through mitotic cell cycle" EXACT []
is_a: GO:0007346 ! regulation of mitotic cell cycle
is_a: GO:0045787 ! positive regulation of cell cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000278 ! mitotic cell cycle
relationship: positively_regulates GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0045932
name: negative regulation of muscle contraction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of muscle contraction." [GOC:go_curators]
synonym: "down regulation of muscle contraction" EXACT []
synonym: "down-regulation of muscle contraction" EXACT []
synonym: "downregulation of muscle contraction" EXACT []
synonym: "inhibition of muscle contraction" NARROW []
is_a: GO:0006937 ! regulation of muscle contraction
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006936 ! muscle contraction
relationship: negatively_regulates GO:0006936 ! muscle contraction

[Term]
id: GO:0045933
name: positive regulation of muscle contraction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of muscle contraction." [GOC:go_curators]
synonym: "activation of muscle contraction" NARROW []
synonym: "stimulation of muscle contraction" NARROW []
synonym: "up regulation of muscle contraction" EXACT []
synonym: "up-regulation of muscle contraction" EXACT []
synonym: "upregulation of muscle contraction" EXACT []
is_a: GO:0006937 ! regulation of muscle contraction
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006936 ! muscle contraction
relationship: positively_regulates GO:0006936 ! muscle contraction

[Term]
id: GO:0045934
name: negative regulation of nucleobase-containing compound metabolic process
namespace: biological_process
def: "Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT []
synonym: "down-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT []
synonym: "downregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT []
synonym: "inhibition of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" NARROW []
synonym: "negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" RELATED [GOC:dph, GOC:tb]
synonym: "negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT []
is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006139 ! nucleobase-containing compound metabolic process
relationship: negatively_regulates GO:0006139 ! nucleobase-containing compound metabolic process

[Term]
id: GO:0045935
name: positive regulation of nucleobase-containing compound metabolic process
namespace: biological_process
def: "Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" NARROW []
synonym: "positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" RELATED [GOC:dph, GOC:tb]
synonym: "positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT []
synonym: "stimulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" NARROW []
synonym: "up regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT []
synonym: "up-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT []
synonym: "upregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT []
is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006139 ! nucleobase-containing compound metabolic process
relationship: positively_regulates GO:0006139 ! nucleobase-containing compound metabolic process

[Term]
id: GO:0045936
name: negative regulation of phosphate metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of phosphate metabolic process" EXACT []
synonym: "down-regulation of phosphate metabolic process" EXACT []
synonym: "downregulation of phosphate metabolic process" EXACT []
synonym: "inhibition of phosphate metabolic process" NARROW []
synonym: "negative regulation of phosphate metabolism" EXACT []
is_a: GO:0010563 ! negative regulation of phosphorus metabolic process
is_a: GO:0019220 ! regulation of phosphate metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006796 ! phosphate-containing compound metabolic process
relationship: negatively_regulates GO:0006796 ! phosphate-containing compound metabolic process

[Term]
id: GO:0045937
name: positive regulation of phosphate metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of phosphate metabolic process" NARROW []
synonym: "positive regulation of phosphate metabolism" EXACT []
synonym: "stimulation of phosphate metabolic process" NARROW []
synonym: "up regulation of phosphate metabolic process" EXACT []
synonym: "up-regulation of phosphate metabolic process" EXACT []
synonym: "upregulation of phosphate metabolic process" EXACT []
is_a: GO:0010562 ! positive regulation of phosphorus metabolic process
is_a: GO:0019220 ! regulation of phosphate metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006796 ! phosphate-containing compound metabolic process
relationship: positively_regulates GO:0006796 ! phosphate-containing compound metabolic process

[Term]
id: GO:0045938
name: positive regulation of circadian sleep/wake cycle, sleep
namespace: biological_process
def: "Any process that activates or increases the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:go_curators]
synonym: "activation of circadian sleep/wake cycle, sleep" NARROW []
synonym: "positive regulation of sleep" EXACT []
synonym: "stimulation of circadian sleep/wake cycle, sleep" NARROW []
synonym: "up regulation of circadian sleep/wake cycle, sleep" EXACT []
synonym: "up-regulation of circadian sleep/wake cycle, sleep" EXACT []
synonym: "upregulation of circadian sleep/wake cycle, sleep" EXACT []
is_a: GO:0042753 ! positive regulation of circadian rhythm
is_a: GO:0045187 ! regulation of circadian sleep/wake cycle, sleep
is_a: GO:0048520 ! positive regulation of behavior
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0050802 ! circadian sleep/wake cycle, sleep
relationship: positively_regulates GO:0050802 ! circadian sleep/wake cycle, sleep

[Term]
id: GO:0045939
name: negative regulation of steroid metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of steroid metabolic process" EXACT []
synonym: "down-regulation of steroid metabolic process" EXACT []
synonym: "downregulation of steroid metabolic process" EXACT []
synonym: "inhibition of steroid metabolic process" NARROW []
synonym: "negative regulation of steroid metabolism" EXACT []
is_a: GO:0019218 ! regulation of steroid metabolic process
is_a: GO:0045833 ! negative regulation of lipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008202 ! steroid metabolic process
relationship: negatively_regulates GO:0008202 ! steroid metabolic process

[Term]
id: GO:0045940
name: positive regulation of steroid metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving steroids." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of steroid metabolic process" NARROW []
synonym: "positive regulation of steroid metabolism" EXACT []
synonym: "stimulation of steroid metabolic process" NARROW []
synonym: "up regulation of steroid metabolic process" EXACT []
synonym: "up-regulation of steroid metabolic process" EXACT []
synonym: "upregulation of steroid metabolic process" EXACT []
is_a: GO:0019218 ! regulation of steroid metabolic process
is_a: GO:0045834 ! positive regulation of lipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008202 ! steroid metabolic process
relationship: positively_regulates GO:0008202 ! steroid metabolic process

[Term]
id: GO:0045942
name: negative regulation of phosphorus utilization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of phosphorus utilization." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of phosphorus utilization" EXACT []
synonym: "down-regulation of phosphorus utilization" EXACT []
synonym: "downregulation of phosphorus utilization" EXACT []
synonym: "inhibition of phosphorus utilization" NARROW []
is_a: GO:0006795 ! regulation of phosphorus utilization
is_a: GO:0048519 ! negative regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006794 ! phosphorus utilization
relationship: negatively_regulates GO:0006794 ! phosphorus utilization

[Term]
id: GO:0045943
name: positive regulation of transcription from RNA polymerase I promoter
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase I promoter." [GOC:go_curators, GOC:txnOH]
synonym: "activation of transcription from RNA polymerase I promoter" NARROW []
synonym: "positive regulation of transcription from Pol I promoter" EXACT []
synonym: "stimulation of transcription from RNA polymerase I promoter" NARROW []
synonym: "up regulation of transcription from RNA polymerase I promoter" EXACT []
synonym: "up-regulation of transcription from RNA polymerase I promoter" EXACT []
synonym: "upregulation of transcription from RNA polymerase I promoter" EXACT []
is_a: GO:0006356 ! regulation of transcription from RNA polymerase I promoter
is_a: GO:0045893 ! positive regulation of transcription, DNA-templated
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006360 ! transcription from RNA polymerase I promoter
relationship: positively_regulates GO:0006360 ! transcription from RNA polymerase I promoter

[Term]
id: GO:0045944
name: positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
alt_id: GO:0010552
alt_id: GO:0045817
def: "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
synonym: "activation of global transcription from RNA polymerase II promoter" RELATED []
synonym: "activation of transcription from RNA polymerase II promoter" EXACT []
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter" RELATED []
synonym: "positive regulation of global transcription from Pol II promoter" RELATED []
synonym: "positive regulation of transcription from Pol II promoter" EXACT []
synonym: "positive regulation of transcription from RNA polymerase II promoter, global" RELATED []
synonym: "stimulation of global transcription from RNA polymerase II promoter" NARROW []
synonym: "stimulation of transcription from RNA polymerase II promoter" EXACT []
synonym: "up regulation of global transcription from RNA polymerase II promoter" RELATED []
synonym: "up regulation of transcription from RNA polymerase II promoter" EXACT []
synonym: "up-regulation of global transcription from RNA polymerase II promoter" RELATED []
synonym: "up-regulation of transcription from RNA polymerase II promoter" EXACT []
synonym: "upregulation of global transcription from RNA polymerase II promoter" RELATED []
synonym: "upregulation of transcription from RNA polymerase II promoter" EXACT []
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0045893 ! positive regulation of transcription, DNA-templated
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006366 ! transcription from RNA polymerase II promoter
relationship: positively_regulates GO:0006366 ! transcription from RNA polymerase II promoter

[Term]
id: GO:0045945
name: positive regulation of transcription from RNA polymerase III promoter
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase III promoter." [GOC:go_curators, GOC:txnOH]
synonym: "activation of transcription from RNA polymerase III promoter" NARROW []
synonym: "positive regulation of transcription from Pol III promoter" EXACT []
synonym: "stimulation of transcription from RNA polymerase III promoter" NARROW []
synonym: "up regulation of transcription from RNA polymerase III promoter" EXACT []
synonym: "up-regulation of transcription from RNA polymerase III promoter" EXACT []
synonym: "upregulation of transcription from RNA polymerase III promoter" EXACT []
is_a: GO:0006359 ! regulation of transcription from RNA polymerase III promoter
is_a: GO:0045893 ! positive regulation of transcription, DNA-templated
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006383 ! transcription from RNA polymerase III promoter
relationship: positively_regulates GO:0006383 ! transcription from RNA polymerase III promoter

[Term]
id: GO:0045947
name: negative regulation of translational initiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of translational initiation" EXACT []
synonym: "down-regulation of translational initiation" EXACT []
synonym: "downregulation of translational initiation" EXACT []
synonym: "inhibition of translational initiation" NARROW []
is_a: GO:0006446 ! regulation of translational initiation
is_a: GO:0017148 ! negative regulation of translation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006413 ! translational initiation
relationship: negatively_regulates GO:0006413 ! translational initiation

[Term]
id: GO:0045948
name: positive regulation of translational initiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of translational initiation." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of translational initiation" NARROW []
synonym: "stimulation of translational initiation" NARROW []
synonym: "up regulation of translational initiation" EXACT []
synonym: "up-regulation of translational initiation" EXACT []
synonym: "upregulation of translational initiation" EXACT []
is_a: GO:0006446 ! regulation of translational initiation
is_a: GO:0045727 ! positive regulation of translation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006413 ! translational initiation
relationship: positively_regulates GO:0006413 ! translational initiation

[Term]
id: GO:0045949
name: positive regulation of phosphorus utilization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phosphorus utilization." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of phosphorus utilization" NARROW []
synonym: "stimulation of phosphorus utilization" NARROW []
synonym: "up regulation of phosphorus utilization" EXACT []
synonym: "up-regulation of phosphorus utilization" EXACT []
synonym: "upregulation of phosphorus utilization" EXACT []
is_a: GO:0006795 ! regulation of phosphorus utilization
is_a: GO:0048518 ! positive regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006794 ! phosphorus utilization
relationship: positively_regulates GO:0006794 ! phosphorus utilization

[Term]
id: GO:0045950
name: negative regulation of mitotic recombination
namespace: biological_process
def: "Any process that inhibits or decreases the rate of DNA recombination during mitosis." [GOC:go_curators, GOC:hjd]
synonym: "down regulation of mitotic recombination" EXACT []
synonym: "down-regulation of mitotic recombination" EXACT []
synonym: "downregulation of mitotic recombination" EXACT []
synonym: "inhibition of mitotic recombination" NARROW []
synonym: "negative regulation of recombination within rDNA repeats" NARROW []
is_a: GO:0000019 ! regulation of mitotic recombination
is_a: GO:0045910 ! negative regulation of DNA recombination
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006312 ! mitotic recombination
relationship: negatively_regulates GO:0006312 ! mitotic recombination

[Term]
id: GO:0045951
name: positive regulation of mitotic recombination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA recombination during mitosis." [GOC:go_curators]
synonym: "activation of mitotic recombination" NARROW []
synonym: "positive regulation of recombination within rDNA repeats" NARROW []
synonym: "stimulation of mitotic recombination" NARROW []
synonym: "up regulation of mitotic recombination" EXACT []
synonym: "up-regulation of mitotic recombination" EXACT []
synonym: "upregulation of mitotic recombination" EXACT []
is_a: GO:0000019 ! regulation of mitotic recombination
is_a: GO:0045911 ! positive regulation of DNA recombination
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006312 ! mitotic recombination
relationship: positively_regulates GO:0006312 ! mitotic recombination

[Term]
id: GO:0045952
name: regulation of juvenile hormone catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of juvenile hormone." [GOC:go_curators]
synonym: "regulation of juvenile hormone breakdown" EXACT []
synonym: "regulation of juvenile hormone catabolism" EXACT []
synonym: "regulation of juvenile hormone degradation" EXACT []
is_a: GO:0007556 ! regulation of juvenile hormone metabolic process
is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:0050994 ! regulation of lipid catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006719 ! juvenile hormone catabolic process
relationship: regulates GO:0006719 ! juvenile hormone catabolic process

[Term]
id: GO:0045953
name: negative regulation of natural killer cell mediated cytotoxicity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of natural killer mediated cytotoxicity." [GOC:add, ISBN:0781735149]
synonym: "down regulation of natural killer cell mediated cytotoxicity" EXACT []
synonym: "down-regulation of natural killer cell mediated cytotoxicity" EXACT []
synonym: "downregulation of natural killer cell mediated cytotoxicity" EXACT []
synonym: "inhibition of natural killer cell mediated cytotoxicity" NARROW []
synonym: "negative regulation of natural killer cell mediated cell death" EXACT []
synonym: "negative regulation of natural killer cell mediated cell killing" EXACT []
synonym: "negative regulation of natural killer cell mediated cytolysis" RELATED []
synonym: "negative regulation of NK cell mediated cell death" EXACT []
synonym: "negative regulation of NK cell mediated cell killing" EXACT []
synonym: "negative regulation of NK cell mediated cytolysis" RELATED []
synonym: "negative regulation of NK cell mediated cytotoxicity" EXACT []
is_a: GO:0001911 ! negative regulation of leukocyte mediated cytotoxicity
is_a: GO:0002716 ! negative regulation of natural killer cell mediated immunity
is_a: GO:0042269 ! regulation of natural killer cell mediated cytotoxicity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042267 ! natural killer cell mediated cytotoxicity
relationship: negatively_regulates GO:0042267 ! natural killer cell mediated cytotoxicity

[Term]
id: GO:0045954
name: positive regulation of natural killer cell mediated cytotoxicity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of natural killer cell mediated cytotoxicity." [GOC:add, ISBN:0781735149]
synonym: "activation of natural killer cell mediated cytotoxicity" NARROW []
synonym: "positive regulation of natural killer cell mediated cell death" EXACT []
synonym: "positive regulation of natural killer cell mediated cell killing" EXACT []
synonym: "positive regulation of natural killer cell mediated cytolysis" RELATED []
synonym: "positive regulation of NK cell mediated cell death" EXACT []
synonym: "positive regulation of NK cell mediated cell killing" EXACT []
synonym: "positive regulation of NK cell mediated cytolysis" RELATED []
synonym: "positive regulation of NK cell mediated cytotoxicity" EXACT []
synonym: "stimulation of natural killer cell mediated cytotoxicity" NARROW []
synonym: "up regulation of natural killer cell mediated cytotoxicity" EXACT []
synonym: "up-regulation of natural killer cell mediated cytotoxicity" EXACT []
synonym: "upregulation of natural killer cell mediated cytotoxicity" EXACT []
is_a: GO:0001912 ! positive regulation of leukocyte mediated cytotoxicity
is_a: GO:0002717 ! positive regulation of natural killer cell mediated immunity
is_a: GO:0042269 ! regulation of natural killer cell mediated cytotoxicity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042267 ! natural killer cell mediated cytotoxicity
relationship: positively_regulates GO:0042267 ! natural killer cell mediated cytotoxicity

[Term]
id: GO:0045955
name: negative regulation of calcium ion-dependent exocytosis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of calcium ion-dependent exocytosis." [GOC:go_curators]
synonym: "down regulation of calcium ion-dependent exocytosis" EXACT []
synonym: "down-regulation of calcium ion-dependent exocytosis" EXACT []
synonym: "downregulation of calcium ion-dependent exocytosis" EXACT []
synonym: "inhibition of calcium ion-dependent exocytosis" NARROW []
is_a: GO:0017158 ! regulation of calcium ion-dependent exocytosis
is_a: GO:1903306 ! negative regulation of regulated secretory pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0017156 ! calcium ion regulated exocytosis
relationship: negatively_regulates GO:0017156 ! calcium ion regulated exocytosis

[Term]
id: GO:0045956
name: positive regulation of calcium ion-dependent exocytosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of calcium ion-dependent exocytosis." [GOC:go_curators]
synonym: "activation of calcium ion-dependent exocytosis" NARROW []
synonym: "stimulation of calcium ion-dependent exocytosis" NARROW []
synonym: "up regulation of calcium ion-dependent exocytosis" EXACT []
synonym: "up-regulation of calcium ion-dependent exocytosis" EXACT []
synonym: "upregulation of calcium ion-dependent exocytosis" EXACT []
is_a: GO:0017158 ! regulation of calcium ion-dependent exocytosis
is_a: GO:1903307 ! positive regulation of regulated secretory pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0017156 ! calcium ion regulated exocytosis
relationship: positively_regulates GO:0017156 ! calcium ion regulated exocytosis

[Term]
id: GO:0045957
name: negative regulation of complement activation, alternative pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the alternative pathway." [GOC:go_curators]
synonym: "down regulation of complement activation, alternative pathway" EXACT []
synonym: "down-regulation of complement activation, alternative pathway" EXACT []
synonym: "downregulation of complement activation, alternative pathway" EXACT []
synonym: "inhibition of complement activation, alternative pathway" NARROW []
synonym: "negative regulation of complement cascade, alternative pathway" EXACT [GOC:add]
is_a: GO:0030451 ! regulation of complement activation, alternative pathway
is_a: GO:0045824 ! negative regulation of innate immune response
is_a: GO:0045916 ! negative regulation of complement activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006957 ! complement activation, alternative pathway
relationship: negatively_regulates GO:0006957 ! complement activation, alternative pathway

[Term]
id: GO:0045958
name: positive regulation of complement activation, alternative pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of complement activation by the alternative pathway." [GOC:go_curators]
synonym: "activation of complement activation, alternative pathway" NARROW []
synonym: "positive regulation of complement cascade, alternative pathway" EXACT [GOC:add]
synonym: "stimulation of complement activation, alternative pathway" NARROW []
synonym: "up regulation of complement activation, alternative pathway" EXACT []
synonym: "up-regulation of complement activation, alternative pathway" EXACT []
synonym: "upregulation of complement activation, alternative pathway" EXACT []
is_a: GO:0030451 ! regulation of complement activation, alternative pathway
is_a: GO:0045089 ! positive regulation of innate immune response
is_a: GO:0045917 ! positive regulation of complement activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006957 ! complement activation, alternative pathway
relationship: positively_regulates GO:0006957 ! complement activation, alternative pathway

[Term]
id: GO:0045959
name: negative regulation of complement activation, classical pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the classical pathway." [GOC:go_curators]
synonym: "down regulation of complement activation, classical pathway" EXACT []
synonym: "down-regulation of complement activation, classical pathway" EXACT []
synonym: "downregulation of complement activation, classical pathway" EXACT []
synonym: "inhibition of complement activation, classical pathway" NARROW []
synonym: "negative regulation of complement cascade, classical pathway" EXACT [GOC:add]
is_a: GO:0002924 ! negative regulation of humoral immune response mediated by circulating immunoglobulin
is_a: GO:0030450 ! regulation of complement activation, classical pathway
is_a: GO:0045916 ! negative regulation of complement activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006958 ! complement activation, classical pathway
relationship: negatively_regulates GO:0006958 ! complement activation, classical pathway

[Term]
id: GO:0045960
name: positive regulation of complement activation, classical pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of complement activation by the classical pathway." [GOC:go_curators]
synonym: "activation of complement activation, classical pathway" NARROW []
synonym: "positive regulation of complement cascade, classical pathway" EXACT [GOC:add]
synonym: "stimulation of complement activation, classical pathway" NARROW []
synonym: "up regulation of complement activation, classical pathway" EXACT []
synonym: "up-regulation of complement activation, classical pathway" EXACT []
synonym: "upregulation of complement activation, classical pathway" EXACT []
is_a: GO:0002925 ! positive regulation of humoral immune response mediated by circulating immunoglobulin
is_a: GO:0030450 ! regulation of complement activation, classical pathway
is_a: GO:0045917 ! positive regulation of complement activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006958 ! complement activation, classical pathway
relationship: positively_regulates GO:0006958 ! complement activation, classical pathway

[Term]
id: GO:0045961
name: negative regulation of development, heterochronic
namespace: biological_process
def: "Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and decreases the rate at which this time point is reached." [GOC:go_curators]
synonym: "down regulation of development, heterochronic" EXACT []
synonym: "down-regulation of development, heterochronic" EXACT []
synonym: "downregulation of development, heterochronic" EXACT []
synonym: "inhibition of development, heterochronic" NARROW []
is_a: GO:0040034 ! regulation of development, heterochronic

[Term]
id: GO:0045962
name: positive regulation of development, heterochronic
namespace: biological_process
def: "Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and increases the rate at which this time point is reached." [GOC:go_curators]
synonym: "activation of development, heterochronic" NARROW []
synonym: "stimulation of development, heterochronic" NARROW []
synonym: "up regulation of development, heterochronic" EXACT []
synonym: "up-regulation of development, heterochronic" EXACT []
synonym: "upregulation of development, heterochronic" EXACT []
is_a: GO:0040034 ! regulation of development, heterochronic

[Term]
id: GO:0045963
name: negative regulation of dopamine metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving dopamine." [GOC:go_curators]
synonym: "down regulation of dopamine metabolic process" EXACT []
synonym: "down-regulation of dopamine metabolic process" EXACT []
synonym: "downregulation of dopamine metabolic process" EXACT []
synonym: "inhibition of dopamine metabolic process" NARROW []
synonym: "negative regulation of dopamine metabolism" EXACT []
is_a: GO:0042053 ! regulation of dopamine metabolic process
is_a: GO:0045914 ! negative regulation of catecholamine metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042417 ! dopamine metabolic process
relationship: negatively_regulates GO:0042417 ! dopamine metabolic process

[Term]
id: GO:0045964
name: positive regulation of dopamine metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving dopamine." [GOC:go_curators]
synonym: "activation of dopamine metabolic process" NARROW []
synonym: "positive regulation of dopamine metabolism" EXACT []
synonym: "stimulation of dopamine metabolic process" NARROW []
synonym: "up regulation of dopamine metabolic process" EXACT []
synonym: "up-regulation of dopamine metabolic process" EXACT []
synonym: "upregulation of dopamine metabolic process" EXACT []
is_a: GO:0042053 ! regulation of dopamine metabolic process
is_a: GO:0045915 ! positive regulation of catecholamine metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042417 ! dopamine metabolic process
relationship: positively_regulates GO:0042417 ! dopamine metabolic process

[Term]
id: GO:0045965
name: negative regulation of ecdysteroid metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving ecdysteroids." [GOC:go_curators]
synonym: "down regulation of ecdysteroid metabolic process" EXACT []
synonym: "down-regulation of ecdysteroid metabolic process" EXACT []
synonym: "downregulation of ecdysteroid metabolic process" EXACT []
synonym: "inhibition of ecdysteroid metabolic process" NARROW []
synonym: "negative regulation of ecdysteroid metabolism" EXACT []
is_a: GO:0007553 ! regulation of ecdysteroid metabolic process
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0032351 ! negative regulation of hormone metabolic process
is_a: GO:0045939 ! negative regulation of steroid metabolic process
is_a: GO:0048581 ! negative regulation of post-embryonic development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045455 ! ecdysteroid metabolic process
relationship: negatively_regulates GO:0045455 ! ecdysteroid metabolic process

[Term]
id: GO:0045966
name: positive regulation of ecdysteroid metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving ecdysteroids." [GOC:go_curators]
synonym: "activation of ecdysteroid metabolic process" NARROW []
synonym: "positive regulation of ecdysteroid metabolism" EXACT []
synonym: "stimulation of ecdysteroid metabolic process" NARROW []
synonym: "up regulation of ecdysteroid metabolic process" EXACT []
synonym: "up-regulation of ecdysteroid metabolic process" EXACT []
synonym: "upregulation of ecdysteroid metabolic process" EXACT []
is_a: GO:0007553 ! regulation of ecdysteroid metabolic process
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0032352 ! positive regulation of hormone metabolic process
is_a: GO:0045940 ! positive regulation of steroid metabolic process
is_a: GO:0048582 ! positive regulation of post-embryonic development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045455 ! ecdysteroid metabolic process
relationship: positively_regulates GO:0045455 ! ecdysteroid metabolic process

[Term]
id: GO:0045967
name: negative regulation of growth rate
namespace: biological_process
def: "Any process that reduces the rate of growth of all or part of an organism." [GOC:mah]
comment: Note that this term and its definition depart from the usual conventions for GO 'regulation' process terms; regulation of rate is not usually distinguished from regulation of extent or frequency, but it makes sense to do so for growth regulation.
synonym: "down regulation of growth rate" EXACT []
synonym: "down-regulation of growth rate" EXACT []
synonym: "downregulation of growth rate" EXACT []
synonym: "inhibition of growth rate" NARROW []
is_a: GO:0040009 ! regulation of growth rate
is_a: GO:0045926 ! negative regulation of growth

[Term]
id: GO:0045968
name: negative regulation of juvenile hormone biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of juvenile hormone." [GOC:go_curators]
synonym: "down regulation of juvenile hormone biosynthetic process" EXACT []
synonym: "down-regulation of juvenile hormone biosynthetic process" EXACT []
synonym: "downregulation of juvenile hormone biosynthetic process" EXACT []
synonym: "inhibition of juvenile hormone biosynthetic process" NARROW []
synonym: "negative regulation of juvenile hormone anabolism" EXACT []
synonym: "negative regulation of juvenile hormone biosynthesis" EXACT []
synonym: "negative regulation of juvenile hormone formation" EXACT []
synonym: "negative regulation of juvenile hormone synthesis" EXACT []
is_a: GO:0007557 ! regulation of juvenile hormone biosynthetic process
is_a: GO:0032353 ! negative regulation of hormone biosynthetic process
is_a: GO:0045928 ! negative regulation of juvenile hormone metabolic process
is_a: GO:0051055 ! negative regulation of lipid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006718 ! juvenile hormone biosynthetic process
relationship: negatively_regulates GO:0006718 ! juvenile hormone biosynthetic process

[Term]
id: GO:0045969
name: positive regulation of juvenile hormone biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of juvenile hormone." [GOC:go_curators]
synonym: "activation of juvenile hormone biosynthetic process" NARROW []
synonym: "positive regulation of juvenile hormone anabolism" EXACT []
synonym: "positive regulation of juvenile hormone biosynthesis" EXACT []
synonym: "positive regulation of juvenile hormone formation" EXACT []
synonym: "positive regulation of juvenile hormone synthesis" EXACT []
synonym: "stimulation of juvenile hormone biosynthetic process" NARROW []
synonym: "up regulation of juvenile hormone biosynthetic process" EXACT []
synonym: "up-regulation of juvenile hormone biosynthetic process" EXACT []
synonym: "upregulation of juvenile hormone biosynthetic process" EXACT []
is_a: GO:0007557 ! regulation of juvenile hormone biosynthetic process
is_a: GO:0045929 ! positive regulation of juvenile hormone metabolic process
is_a: GO:0046886 ! positive regulation of hormone biosynthetic process
is_a: GO:0046889 ! positive regulation of lipid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006718 ! juvenile hormone biosynthetic process
relationship: positively_regulates GO:0006718 ! juvenile hormone biosynthetic process

[Term]
id: GO:0045970
name: negative regulation of juvenile hormone catabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of juvenile hormone." [GOC:go_curators]
synonym: "down regulation of juvenile hormone catabolic process" EXACT []
synonym: "down-regulation of juvenile hormone catabolic process" EXACT []
synonym: "downregulation of juvenile hormone catabolic process" EXACT []
synonym: "inhibition of juvenile hormone catabolic process" NARROW []
synonym: "negative regulation of juvenile hormone breakdown" EXACT []
synonym: "negative regulation of juvenile hormone catabolism" EXACT []
synonym: "negative regulation of juvenile hormone degradation" EXACT []
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:0045928 ! negative regulation of juvenile hormone metabolic process
is_a: GO:0045952 ! regulation of juvenile hormone catabolic process
is_a: GO:0050995 ! negative regulation of lipid catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006719 ! juvenile hormone catabolic process
relationship: negatively_regulates GO:0006719 ! juvenile hormone catabolic process

[Term]
id: GO:0045971
name: positive regulation of juvenile hormone catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of juvenile hormone." [GOC:go_curators]
synonym: "activation of juvenile hormone catabolic process" NARROW []
synonym: "positive regulation of juvenile hormone breakdown" EXACT []
synonym: "positive regulation of juvenile hormone catabolism" EXACT []
synonym: "positive regulation of juvenile hormone degradation" EXACT []
synonym: "stimulation of juvenile hormone catabolic process" NARROW []
synonym: "up regulation of juvenile hormone catabolic process" EXACT []
synonym: "up-regulation of juvenile hormone catabolic process" EXACT []
synonym: "upregulation of juvenile hormone catabolic process" EXACT []
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:0045929 ! positive regulation of juvenile hormone metabolic process
is_a: GO:0045952 ! regulation of juvenile hormone catabolic process
is_a: GO:0050996 ! positive regulation of lipid catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006719 ! juvenile hormone catabolic process
relationship: positively_regulates GO:0006719 ! juvenile hormone catabolic process

[Term]
id: GO:0045972
name: negative regulation of juvenile hormone secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of juvenile hormone." [GOC:go_curators]
synonym: "down regulation of juvenile hormone secretion" EXACT []
synonym: "down-regulation of juvenile hormone secretion" EXACT []
synonym: "downregulation of juvenile hormone secretion" EXACT []
synonym: "inhibition of juvenile hormone secretion" NARROW []
is_a: GO:0007558 ! regulation of juvenile hormone secretion
is_a: GO:0032369 ! negative regulation of lipid transport
is_a: GO:0046888 ! negative regulation of hormone secretion
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045443 ! juvenile hormone secretion
relationship: negatively_regulates GO:0045443 ! juvenile hormone secretion

[Term]
id: GO:0045973
name: positive regulation of juvenile hormone secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of juvenile hormone." [GOC:go_curators]
synonym: "activation of juvenile hormone secretion" NARROW []
synonym: "stimulation of juvenile hormone secretion" NARROW []
synonym: "up regulation of juvenile hormone secretion" EXACT []
synonym: "up-regulation of juvenile hormone secretion" EXACT []
synonym: "upregulation of juvenile hormone secretion" EXACT []
is_a: GO:0007558 ! regulation of juvenile hormone secretion
is_a: GO:0032370 ! positive regulation of lipid transport
is_a: GO:0046887 ! positive regulation of hormone secretion
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045443 ! juvenile hormone secretion
relationship: positively_regulates GO:0045443 ! juvenile hormone secretion

[Term]
id: GO:0045974
name: regulation of translation, ncRNA-mediated
namespace: biological_process
def: "Any process, mediated by small non-coding RNAs, that modulates the frequency, rate or extent that mRNAs are effectively translated into protein." [GOC:dph, GOC:go_curators, GOC:tb]
is_a: GO:0006417 ! regulation of translation

[Term]
id: GO:0045975
name: positive regulation of translation, ncRNA-mediated
namespace: biological_process
def: "Any process, mediated by small non-coding RNAs, that activates or increases the rate that mRNAs are effectively translated into protein." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "activation of mRNA translation, ncRNA-mediated" NARROW []
synonym: "stimulation of mRNA translation, ncRNA-mediated" NARROW []
synonym: "up regulation of mRNA translation, ncRNA-mediated" EXACT []
synonym: "up-regulation of mRNA translation, ncRNA-mediated" EXACT []
synonym: "upregulation of mRNA translation, ncRNA-mediated" EXACT []
is_a: GO:0045727 ! positive regulation of translation
is_a: GO:0045974 ! regulation of translation, ncRNA-mediated

[Term]
id: GO:0045976
name: negative regulation of mitotic cell cycle, embryonic
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of progression through the embryonic mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "down regulation of progression through embryonic mitotic cell cycle" EXACT []
synonym: "down-regulation of progression through embryonic mitotic cell cycle" EXACT []
synonym: "downregulation of progression through embryonic mitotic cell cycle" EXACT []
synonym: "inhibition of progression through embryonic mitotic cell cycle" NARROW []
synonym: "negative regulation of embryonic mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of embryonic mitotic cell cycle progression" EXACT []
synonym: "negative regulation of progression through embryonic mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
is_a: GO:0009794 ! regulation of mitotic cell cycle, embryonic
is_a: GO:0045930 ! negative regulation of mitotic cell cycle
is_a: GO:0045992 ! negative regulation of embryonic development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045448 ! mitotic cell cycle, embryonic
relationship: negatively_regulates GO:0045448 ! mitotic cell cycle, embryonic

[Term]
id: GO:0045977
name: positive regulation of mitotic cell cycle, embryonic
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of progression through the embryonic mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "activation of mitotic cell cycle, embryonic" NARROW []
synonym: "positive regulation of embryonic mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of embryonic mitotic cell cycle progression" EXACT []
synonym: "positive regulation of progression through embryonic mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of mitotic cell cycle, embryonic" NARROW []
synonym: "up regulation of mitotic cell cycle, embryonic" EXACT []
synonym: "up-regulation of mitotic cell cycle, embryonic" EXACT []
synonym: "upregulation of mitotic cell cycle, embryonic" EXACT []
is_a: GO:0009794 ! regulation of mitotic cell cycle, embryonic
is_a: GO:0040019 ! positive regulation of embryonic development
is_a: GO:0045931 ! positive regulation of mitotic cell cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045448 ! mitotic cell cycle, embryonic
relationship: positively_regulates GO:0045448 ! mitotic cell cycle, embryonic

[Term]
id: GO:0045978
name: negative regulation of nucleoside metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleosides." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of nucleoside metabolic process" EXACT []
synonym: "down-regulation of nucleoside metabolic process" EXACT []
synonym: "downregulation of nucleoside metabolic process" EXACT []
synonym: "inhibition of nucleoside metabolic process" NARROW []
synonym: "negative regulation of nucleoside metabolism" EXACT []
is_a: GO:0009118 ! regulation of nucleoside metabolic process
is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009116 ! nucleoside metabolic process
relationship: negatively_regulates GO:0009116 ! nucleoside metabolic process

[Term]
id: GO:0045979
name: positive regulation of nucleoside metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleosides." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of nucleoside metabolic process" NARROW []
synonym: "positive regulation of nucleoside metabolism" EXACT []
synonym: "stimulation of nucleoside metabolic process" NARROW []
synonym: "up regulation of nucleoside metabolic process" EXACT []
synonym: "up-regulation of nucleoside metabolic process" EXACT []
synonym: "upregulation of nucleoside metabolic process" EXACT []
is_a: GO:0009118 ! regulation of nucleoside metabolic process
is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009116 ! nucleoside metabolic process
relationship: positively_regulates GO:0009116 ! nucleoside metabolic process

[Term]
id: GO:0045980
name: negative regulation of nucleotide metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleotides." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of nucleotide metabolic process" EXACT []
synonym: "down-regulation of nucleotide metabolic process" EXACT []
synonym: "downregulation of nucleotide metabolic process" EXACT []
synonym: "inhibition of nucleotide metabolic process" NARROW []
synonym: "negative regulation of nucleotide metabolism" EXACT []
is_a: GO:0006140 ! regulation of nucleotide metabolic process
is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process
is_a: GO:0045936 ! negative regulation of phosphate metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009117 ! nucleotide metabolic process
relationship: negatively_regulates GO:0009117 ! nucleotide metabolic process

[Term]
id: GO:0045981
name: positive regulation of nucleotide metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleotides." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of nucleotide metabolic process" NARROW []
synonym: "positive regulation of nucleotide metabolism" EXACT []
synonym: "stimulation of nucleotide metabolic process" NARROW []
synonym: "up regulation of nucleotide metabolic process" EXACT []
synonym: "up-regulation of nucleotide metabolic process" EXACT []
synonym: "upregulation of nucleotide metabolic process" EXACT []
is_a: GO:0006140 ! regulation of nucleotide metabolic process
is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process
is_a: GO:0045937 ! positive regulation of phosphate metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009117 ! nucleotide metabolic process
relationship: positively_regulates GO:0009117 ! nucleotide metabolic process

[Term]
id: GO:0045982
name: negative regulation of purine nucleobase metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving purine nucleobases." [CHEBI:26386, GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of purine base metabolic process" EXACT []
synonym: "down-regulation of purine base metabolic process" EXACT []
synonym: "downregulation of purine base metabolic process" EXACT []
synonym: "inhibition of purine base metabolic process" NARROW []
synonym: "negative regulation of purine base metabolic process" EXACT [GOC:go_curators]
synonym: "negative regulation of purine base metabolism" EXACT []
is_a: GO:0006141 ! regulation of purine nucleobase metabolic process
is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006144 ! purine nucleobase metabolic process
relationship: negatively_regulates GO:0006144 ! purine nucleobase metabolic process

[Term]
id: GO:0045983
name: positive regulation of purine nucleobase metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving purine bases." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of purine base metabolic process" NARROW []
synonym: "positive regulation of purine base metabolic process" EXACT [GOC:curators]
synonym: "positive regulation of purine base metabolism" EXACT []
synonym: "stimulation of purine base metabolic process" NARROW []
synonym: "up regulation of purine base metabolic process" EXACT []
synonym: "up-regulation of purine base metabolic process" EXACT []
synonym: "upregulation of purine base metabolic process" EXACT []
is_a: GO:0006141 ! regulation of purine nucleobase metabolic process
is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006144 ! purine nucleobase metabolic process
relationship: positively_regulates GO:0006144 ! purine nucleobase metabolic process

[Term]
id: GO:0045984
name: negative regulation of pyrimidine nucleobase metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving pyrimidine nucleobases." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of pyrimidine base metabolic process" EXACT []
synonym: "down-regulation of pyrimidine base metabolic process" EXACT []
synonym: "downregulation of pyrimidine base metabolic process" EXACT []
synonym: "inhibition of pyrimidine base metabolic process" NARROW []
synonym: "negative regulation of pyrimidine base metabolic process" EXACT [GOC:go_curators]
synonym: "negative regulation of pyrimidine base metabolism" EXACT []
is_a: GO:0006142 ! regulation of pyrimidine nucleobase metabolic process
is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006206 ! pyrimidine nucleobase metabolic process
relationship: negatively_regulates GO:0006206 ! pyrimidine nucleobase metabolic process

[Term]
id: GO:0045985
name: positive regulation of pyrimidine nucleobase metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving pyrimidine nucleobases." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of pyrimidine base metabolic process" NARROW []
synonym: "positive regulation of pyrimidine base metabolic process" EXACT [GOC:go_curators]
synonym: "positive regulation of pyrimidine base metabolism" EXACT []
synonym: "stimulation of pyrimidine base metabolic process" NARROW []
synonym: "up regulation of pyrimidine base metabolic process" EXACT []
synonym: "up-regulation of pyrimidine base metabolic process" EXACT []
synonym: "upregulation of pyrimidine base metabolic process" EXACT []
is_a: GO:0006142 ! regulation of pyrimidine nucleobase metabolic process
is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006206 ! pyrimidine nucleobase metabolic process
relationship: positively_regulates GO:0006206 ! pyrimidine nucleobase metabolic process

[Term]
id: GO:0045986
name: negative regulation of smooth muscle contraction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle contraction." [GOC:go_curators]
synonym: "down regulation of smooth muscle contraction" EXACT []
synonym: "down-regulation of smooth muscle contraction" EXACT []
synonym: "downregulation of smooth muscle contraction" EXACT []
synonym: "inhibition of smooth muscle contraction" NARROW []
synonym: "smooth muscle relaxation" RELATED []
is_a: GO:0006940 ! regulation of smooth muscle contraction
is_a: GO:0045932 ! negative regulation of muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006939 ! smooth muscle contraction
relationship: negatively_regulates GO:0006939 ! smooth muscle contraction

[Term]
id: GO:0045987
name: positive regulation of smooth muscle contraction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of smooth muscle contraction." [GOC:go_curators]
synonym: "activation of smooth muscle contraction" NARROW []
synonym: "stimulation of smooth muscle contraction" NARROW []
synonym: "up regulation of smooth muscle contraction" EXACT []
synonym: "up-regulation of smooth muscle contraction" EXACT []
synonym: "upregulation of smooth muscle contraction" EXACT []
is_a: GO:0006940 ! regulation of smooth muscle contraction
is_a: GO:0045933 ! positive regulation of muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006939 ! smooth muscle contraction
relationship: positively_regulates GO:0006939 ! smooth muscle contraction

[Term]
id: GO:0045988
name: negative regulation of striated muscle contraction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle contraction." [GOC:go_curators]
synonym: "down regulation of striated muscle contraction" EXACT []
synonym: "down-regulation of striated muscle contraction" EXACT []
synonym: "downregulation of striated muscle contraction" EXACT []
synonym: "inhibition of striated muscle contraction" NARROW []
is_a: GO:0006942 ! regulation of striated muscle contraction
is_a: GO:0045932 ! negative regulation of muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006941 ! striated muscle contraction
relationship: negatively_regulates GO:0006941 ! striated muscle contraction

[Term]
id: GO:0045989
name: positive regulation of striated muscle contraction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of striated muscle contraction." [GOC:go_curators]
synonym: "activation of striated muscle contraction" NARROW []
synonym: "stimulation of striated muscle contraction" NARROW []
synonym: "up regulation of striated muscle contraction" EXACT []
synonym: "up-regulation of striated muscle contraction" EXACT []
synonym: "upregulation of striated muscle contraction" EXACT []
is_a: GO:0006942 ! regulation of striated muscle contraction
is_a: GO:0045933 ! positive regulation of muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006941 ! striated muscle contraction
relationship: positively_regulates GO:0006941 ! striated muscle contraction

[Term]
id: GO:0045990
name: carbon catabolite regulation of transcription
namespace: biological_process
def: "A transcription regulation process in which the presence of one carbon source leads to the modulation of the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources." [GOC:go_curators, GOC:mah, PMID:18359269, PMID:9618445]
subset: gosubset_prok
synonym: "regulation of transcription by carbon catabolites" EXACT [GOC:mah]
is_a: GO:0006355 ! regulation of transcription, DNA-templated
relationship: part_of GO:0031670 ! cellular response to nutrient

[Term]
id: GO:0045991
name: carbon catabolite activation of transcription
namespace: biological_process
def: "A transcription regulation process in which the presence of one carbon source leads to an increase in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources." [GOC:mah, PMID:10559153]
subset: gosubset_prok
synonym: "positive regulation of transcription by carbon catabolites" EXACT [GOC:mah]
is_a: GO:0045893 ! positive regulation of transcription, DNA-templated
is_a: GO:0045990 ! carbon catabolite regulation of transcription

[Term]
id: GO:0045992
name: negative regulation of embryonic development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of embryonic development." [GOC:go_curators]
synonym: "down regulation of embryonic development" EXACT []
synonym: "down-regulation of embryonic development" EXACT []
synonym: "downregulation of embryonic development" EXACT []
synonym: "inhibition of embryonic development" NARROW []
is_a: GO:0045995 ! regulation of embryonic development
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009790 ! embryo development
relationship: negatively_regulates GO:0009790 ! embryo development

[Term]
id: GO:0045993
name: negative regulation of translational initiation by iron
namespace: biological_process
def: "Any process involving iron that stops, prevents or reduces the rate of translational initiation." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of translational initiation by iron" EXACT []
synonym: "down-regulation of translational initiation by iron" EXACT []
synonym: "downregulation of translational initiation by iron" EXACT []
synonym: "inhibition of translational initiation by iron" NARROW []
is_a: GO:0006447 ! regulation of translational initiation by iron
is_a: GO:0045947 ! negative regulation of translational initiation

[Term]
id: GO:0045994
name: positive regulation of translational initiation by iron
namespace: biological_process
def: "Any process involving iron that activates or increases the rate of translational initiation." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of translational initiation by iron" NARROW []
synonym: "stimulation of translational initiation by iron" NARROW []
synonym: "up regulation of translational initiation by iron" EXACT []
synonym: "up-regulation of translational initiation by iron" EXACT []
synonym: "upregulation of translational initiation by iron" EXACT []
is_a: GO:0006447 ! regulation of translational initiation by iron
is_a: GO:0045948 ! positive regulation of translational initiation

[Term]
id: GO:0045995
name: regulation of embryonic development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of embryonic development." [GOC:go_curators]
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009790 ! embryo development
relationship: regulates GO:0009790 ! embryo development

[Term]
id: GO:0045996
name: negative regulation of transcription by pheromones
namespace: biological_process
def: "Any process involving pheromones that stops, prevents or reduces the rate of transcription." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of transcription by pheromones" EXACT []
synonym: "down-regulation of transcription by pheromones" EXACT []
synonym: "downregulation of transcription by pheromones" EXACT []
synonym: "inhibition of transcription by pheromones" NARROW []
is_a: GO:0009373 ! regulation of transcription by pheromones
is_a: GO:0045892 ! negative regulation of transcription, DNA-templated

[Term]
id: GO:0045997
name: negative regulation of ecdysteroid biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ecdysteroids." [GOC:go_curators]
synonym: "down regulation of ecdysteroid biosynthetic process" EXACT []
synonym: "down-regulation of ecdysteroid biosynthetic process" EXACT []
synonym: "downregulation of ecdysteroid biosynthetic process" EXACT []
synonym: "inhibition of ecdysteroid biosynthetic process" NARROW []
synonym: "negative regulation of ecdysteroid anabolism" EXACT []
synonym: "negative regulation of ecdysteroid biosynthesis" EXACT []
synonym: "negative regulation of ecdysteroid formation" EXACT []
synonym: "negative regulation of ecdysteroid synthesis" EXACT []
is_a: GO:0007554 ! regulation of ecdysteroid biosynthetic process
is_a: GO:0045965 ! negative regulation of ecdysteroid metabolic process
is_a: GO:0090032 ! negative regulation of steroid hormone biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045456 ! ecdysteroid biosynthetic process
relationship: negatively_regulates GO:0045456 ! ecdysteroid biosynthetic process

[Term]
id: GO:0045998
name: positive regulation of ecdysteroid biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ecdysteroids." [GOC:go_curators]
synonym: "activation of ecdysteroid biosynthetic process" NARROW []
synonym: "positive regulation of ecdysteroid anabolism" EXACT []
synonym: "positive regulation of ecdysteroid biosynthesis" EXACT []
synonym: "positive regulation of ecdysteroid formation" EXACT []
synonym: "positive regulation of ecdysteroid synthesis" EXACT []
synonym: "stimulation of ecdysteroid biosynthetic process" NARROW []
synonym: "up regulation of ecdysteroid biosynthetic process" EXACT []
synonym: "up-regulation of ecdysteroid biosynthetic process" EXACT []
synonym: "upregulation of ecdysteroid biosynthetic process" EXACT []
is_a: GO:0007554 ! regulation of ecdysteroid biosynthetic process
is_a: GO:0045966 ! positive regulation of ecdysteroid metabolic process
is_a: GO:0090031 ! positive regulation of steroid hormone biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045456 ! ecdysteroid biosynthetic process
relationship: positively_regulates GO:0045456 ! ecdysteroid biosynthetic process

[Term]
id: GO:0045999
name: negative regulation of ecdysteroid secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of ecdysteroid." [GOC:go_curators]
synonym: "down regulation of ecdysteroid secretion" EXACT []
synonym: "down-regulation of ecdysteroid secretion" EXACT []
synonym: "downregulation of ecdysteroid secretion" EXACT []
synonym: "inhibition of ecdysteroid secretion" NARROW []
is_a: GO:0007555 ! regulation of ecdysteroid secretion
is_a: GO:2000832 ! negative regulation of steroid hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045457 ! ecdysteroid secretion
relationship: negatively_regulates GO:0045457 ! ecdysteroid secretion

[Term]
id: GO:0046000
name: positive regulation of ecdysteroid secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of ecdysteroid." [GOC:go_curators]
synonym: "activation of ecdysteroid secretion" NARROW []
synonym: "stimulation of ecdysteroid secretion" NARROW []
synonym: "up regulation of ecdysteroid secretion" EXACT []
synonym: "up-regulation of ecdysteroid secretion" EXACT []
synonym: "upregulation of ecdysteroid secretion" EXACT []
is_a: GO:0007555 ! regulation of ecdysteroid secretion
is_a: GO:2000833 ! positive regulation of steroid hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045457 ! ecdysteroid secretion
relationship: positively_regulates GO:0045457 ! ecdysteroid secretion

[Term]
id: GO:0046001
name: negative regulation of preblastoderm mitotic cell cycle
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of progression through the preblastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "down regulation of progression through preblastoderm mitotic cell cycle" EXACT []
synonym: "down-regulation of progression through preblastoderm mitotic cell cycle" EXACT []
synonym: "downregulation of progression through preblastoderm mitotic cell cycle" EXACT []
synonym: "inhibition of progression through preblastoderm mitotic cell cycle" NARROW []
synonym: "negative regulation of preblastoderm mitotic cell cycle progression" EXACT []
synonym: "negative regulation of progression through preblastoderm mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
is_a: GO:0007347 ! regulation of preblastoderm mitotic cell cycle
is_a: GO:0045976 ! negative regulation of mitotic cell cycle, embryonic
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035185 ! preblastoderm mitotic cell cycle
relationship: negatively_regulates GO:0035185 ! preblastoderm mitotic cell cycle

[Term]
id: GO:0046002
name: positive regulation of preblastoderm mitotic cell cycle
namespace: biological_process
def: "Any process that activates or increases the rate or extent of progression through the preblastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "activation of progression through preblastoderm mitotic cell cycle" NARROW []
synonym: "positive regulation of preblastoderm mitotic cell cycle progression" EXACT []
synonym: "positive regulation of progression through preblastoderm mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of progression through preblastoderm mitotic cell cycle" NARROW []
synonym: "up regulation of progression through preblastoderm mitotic cell cycle" EXACT []
synonym: "up-regulation of progression through preblastoderm mitotic cell cycle" EXACT []
synonym: "upregulation of progression through preblastoderm mitotic cell cycle" EXACT []
is_a: GO:0007347 ! regulation of preblastoderm mitotic cell cycle
is_a: GO:0045977 ! positive regulation of mitotic cell cycle, embryonic
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035185 ! preblastoderm mitotic cell cycle
relationship: positively_regulates GO:0035185 ! preblastoderm mitotic cell cycle

[Term]
id: GO:0046003
name: negative regulation of syncytial blastoderm mitotic cell cycle
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of progression through the syncytial blastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "down regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT []
synonym: "down-regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT []
synonym: "downregulation of progression through syncytial blastoderm mitotic cell cycle" EXACT []
synonym: "inhibition of progression through syncytial blastoderm mitotic cell cycle" NARROW []
synonym: "negative regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of syncytial blastoderm cell cycle progression" EXACT []
is_a: GO:0007348 ! regulation of syncytial blastoderm mitotic cell cycle
is_a: GO:0045976 ! negative regulation of mitotic cell cycle, embryonic
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035186 ! syncytial blastoderm mitotic cell cycle
relationship: negatively_regulates GO:0035186 ! syncytial blastoderm mitotic cell cycle

[Term]
id: GO:0046004
name: positive regulation of syncytial blastoderm mitotic cell cycle
namespace: biological_process
def: "Any process that activates or increases the rate or extent of progression through the syncytial blastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "activation of progression through syncytial blastoderm mitotic cell cycle" NARROW []
synonym: "positive regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of syncytial blastoderm cell cycle progression" EXACT []
synonym: "stimulation of progression through syncytial blastoderm mitotic cell cycle" NARROW []
synonym: "up regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT []
synonym: "up-regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT []
synonym: "upregulation of progression through syncytial blastoderm mitotic cell cycle" EXACT []
is_a: GO:0007348 ! regulation of syncytial blastoderm mitotic cell cycle
is_a: GO:0045977 ! positive regulation of mitotic cell cycle, embryonic
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035186 ! syncytial blastoderm mitotic cell cycle
relationship: positively_regulates GO:0035186 ! syncytial blastoderm mitotic cell cycle

[Term]
id: GO:0046005
name: positive regulation of circadian sleep/wake cycle, REM sleep
namespace: biological_process
def: "Any process that activates or increases the duration or quality of rapid eye movement (REM) sleep." [GOC:go_curators]
synonym: "activation of circadian sleep/wake cycle, REM sleep" NARROW []
synonym: "positive regulation of REM sleep" EXACT []
synonym: "stimulation of circadian sleep/wake cycle, REM sleep" NARROW []
synonym: "up regulation of circadian sleep/wake cycle, REM sleep" EXACT []
synonym: "up-regulation of circadian sleep/wake cycle, REM sleep" EXACT []
synonym: "upregulation of circadian sleep/wake cycle, REM sleep" EXACT []
is_a: GO:0042320 ! regulation of circadian sleep/wake cycle, REM sleep
is_a: GO:0045938 ! positive regulation of circadian sleep/wake cycle, sleep
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042747 ! circadian sleep/wake cycle, REM sleep
relationship: positively_regulates GO:0042747 ! circadian sleep/wake cycle, REM sleep

[Term]
id: GO:0046006
name: regulation of activated T cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of activated T cell proliferation." [GOC:go_curators]
synonym: "regulation of activated T lymphocyte proliferation" EXACT []
synonym: "regulation of activated T-cell proliferation" EXACT []
synonym: "regulation of activated T-lymphocyte proliferation" EXACT []
is_a: GO:0042129 ! regulation of T cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050798 ! activated T cell proliferation
relationship: regulates GO:0050798 ! activated T cell proliferation

[Term]
id: GO:0046007
name: negative regulation of activated T cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of activated T cell proliferation." [GOC:go_curators]
synonym: "down regulation of activated T cell proliferation" EXACT []
synonym: "down-regulation of activated T cell proliferation" EXACT []
synonym: "downregulation of activated T cell proliferation" EXACT []
synonym: "inhibition of activated T cell proliferation" NARROW []
synonym: "negative regulation of activated T lymphocyte proliferation" EXACT []
synonym: "negative regulation of activated T-cell proliferation" EXACT []
synonym: "negative regulation of activated T-lymphocyte proliferation" EXACT []
is_a: GO:0042130 ! negative regulation of T cell proliferation
is_a: GO:0046006 ! regulation of activated T cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0050798 ! activated T cell proliferation
relationship: negatively_regulates GO:0050798 ! activated T cell proliferation

[Term]
id: GO:0046008
name: regulation of female receptivity, post-mating
namespace: biological_process
def: "Any process that modulates the receptiveness of a female to male advances subsequent to mating." [GOC:go_curators]
is_a: GO:0045924 ! regulation of female receptivity

[Term]
id: GO:0046009
name: positive regulation of female receptivity, post-mating
namespace: biological_process
def: "Any process that increases the receptiveness of a female to male advances subsequent to mating." [GOC:go_curators]
synonym: "activation of female receptivity, post-mating" NARROW []
synonym: "stimulation of female receptivity, post-mating" NARROW []
synonym: "up regulation of female receptivity, post-mating" EXACT []
synonym: "up-regulation of female receptivity, post-mating" EXACT []
synonym: "upregulation of female receptivity, post-mating" EXACT []
is_a: GO:0045925 ! positive regulation of female receptivity
is_a: GO:0046008 ! regulation of female receptivity, post-mating

[Term]
id: GO:0046010
name: positive regulation of circadian sleep/wake cycle, non-REM sleep
namespace: biological_process
def: "Any process that activates or increases the duration or quality of non-rapid eye movement (NREM) sleep." [GOC:go_curators]
synonym: "activation of circadian sleep/wake cycle, non-REM sleep" NARROW []
synonym: "positive regulation of non-REM sleep" EXACT []
synonym: "stimulation of circadian sleep/wake cycle, non-REM sleep" NARROW []
synonym: "up regulation of circadian sleep/wake cycle, non-REM sleep" EXACT []
synonym: "up-regulation of circadian sleep/wake cycle, non-REM sleep" EXACT []
synonym: "upregulation of circadian sleep/wake cycle, non-REM sleep" EXACT []
is_a: GO:0045188 ! regulation of circadian sleep/wake cycle, non-REM sleep
is_a: GO:0045938 ! positive regulation of circadian sleep/wake cycle, sleep
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042748 ! circadian sleep/wake cycle, non-REM sleep
relationship: positively_regulates GO:0042748 ! circadian sleep/wake cycle, non-REM sleep

[Term]
id: GO:0046011
name: regulation of oskar mRNA translation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of oskar mRNA translation. To ensure the localization of Oskar protein at the posterior pole of the oocyte, translation of oskar mRNA is repressed during its transport to the posterior pole and activated upon localization of the mRNA at the posterior cortex." [GOC:go_curators, PMID:12538512]
is_a: GO:0006417 ! regulation of translation

[Term]
id: GO:0046012
name: positive regulation of oskar mRNA translation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of oskar mRNA translation." [GOC:go_curators]
synonym: "activation of oskar mRNA translation" NARROW []
synonym: "stimulation of oskar mRNA translation" NARROW []
synonym: "up regulation of oskar mRNA translation" EXACT []
synonym: "up-regulation of oskar mRNA translation" EXACT []
synonym: "upregulation of oskar mRNA translation" EXACT []
is_a: GO:0045727 ! positive regulation of translation
is_a: GO:0046011 ! regulation of oskar mRNA translation

[Term]
id: GO:0046013
name: regulation of T cell homeostatic proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of resting T cell proliferation." [GOC:go_curators]
synonym: "regulation of resting T cell proliferation" EXACT []
synonym: "regulation of T lymphocyte homeostatic proliferation" EXACT []
synonym: "regulation of T-cell homeostatic proliferation" EXACT []
synonym: "regulation of T-lymphocyte homeostatic proliferation" EXACT []
is_a: GO:0032844 ! regulation of homeostatic process
is_a: GO:0042129 ! regulation of T cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001777 ! T cell homeostatic proliferation
relationship: regulates GO:0001777 ! T cell homeostatic proliferation

[Term]
id: GO:0046014
name: negative regulation of T cell homeostatic proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of resting T cell proliferation." [GOC:go_curators]
synonym: "down regulation of T cell homeostatic proliferation" EXACT []
synonym: "down-regulation of T cell homeostatic proliferation" EXACT []
synonym: "downregulation of T cell homeostatic proliferation" EXACT []
synonym: "inhibition of T cell homeostatic proliferation" NARROW []
synonym: "negative regulation of resting T cell proliferation" EXACT []
synonym: "negative regulation of T lymphocyte homeostatic proliferation" EXACT []
synonym: "negative regulation of T-cell homeostatic proliferation" EXACT []
synonym: "negative regulation of T-lymphocyte homeostatic proliferation" EXACT []
is_a: GO:0032845 ! negative regulation of homeostatic process
is_a: GO:0042130 ! negative regulation of T cell proliferation
is_a: GO:0046013 ! regulation of T cell homeostatic proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001777 ! T cell homeostatic proliferation
relationship: negatively_regulates GO:0001777 ! T cell homeostatic proliferation

[Term]
id: GO:0046015
name: regulation of transcription by glucose
namespace: biological_process
def: "Any process involving glucose that modulates the frequency, rate or extent or transcription." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0006355 ! regulation of transcription, DNA-templated

[Term]
id: GO:0046016
name: positive regulation of transcription by glucose
namespace: biological_process
def: "Any process involving glucose that activates or increases the rate of transcription." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of transcription by glucose" NARROW []
synonym: "stimulation of transcription by glucose" NARROW []
synonym: "up regulation of transcription by glucose" EXACT []
synonym: "up-regulation of transcription by glucose" EXACT []
synonym: "upregulation of transcription by glucose" EXACT []
is_a: GO:0045991 ! carbon catabolite activation of transcription
is_a: GO:0046015 ! regulation of transcription by glucose

[Term]
id: GO:0046017
name: regulation of transcription from RNA polymerase I promoter, mitotic
namespace: biological_process
def: "A cell cycle process that modulates the frequency, rate or extent of transcription from an RNA polymerase I promoter during mitosis." [GOC:go_curators]
synonym: "mitotic regulation of transcription from Pol I promoter" EXACT []
synonym: "regulation of transcription from Pol I promoter during mitosis" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of transcription from RNA polymerase I promoter during mitosis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0006356 ! regulation of transcription from RNA polymerase I promoter
is_a: GO:0045896 ! regulation of transcription during mitosis
intersection_of: GO:0006356 ! regulation of transcription from RNA polymerase I promoter
intersection_of: part_of GO:0007067 ! mitotic nuclear division
relationship: part_of GO:0007067 ! mitotic nuclear division

[Term]
id: GO:0046018
name: positive regulation of transcription from RNA polymerase I promoter during mitosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase I promoter during mitosis." [GOC:go_curators]
synonym: "activation of transcription from RNA polymerase I promoter during mitosis" NARROW [GOC:mah]
synonym: "mitotic activation of transcription from Pol I promoter" EXACT []
synonym: "positive regulation of transcription from Pol I promoter during mitosis" EXACT [GOC:mah]
synonym: "positive regulation of transcription from RNA polymerase I promoter, mitotic" EXACT [GOC:mah]
synonym: "stimulation of transcription from RNA polymerase I promoter during mitosis" NARROW [GOC:mah]
synonym: "up regulation of transcription from RNA polymerase I promoter during mitosis" EXACT [GOC:mah]
synonym: "up-regulation of transcription from RNA polymerase I promoter during mitosis" EXACT [GOC:mah]
synonym: "upregulation of transcription from RNA polymerase I promoter during mitosis" EXACT [GOC:mah]
is_a: GO:0045897 ! positive regulation of transcription during mitosis
is_a: GO:0045943 ! positive regulation of transcription from RNA polymerase I promoter
is_a: GO:0046017 ! regulation of transcription from RNA polymerase I promoter, mitotic
intersection_of: GO:0045943 ! positive regulation of transcription from RNA polymerase I promoter
intersection_of: part_of GO:0007067 ! mitotic nuclear division
relationship: part_of GO:0007067 ! mitotic nuclear division

[Term]
id: GO:0046019
name: regulation of transcription from RNA polymerase II promoter by pheromones
namespace: biological_process
def: "Any process involving pheromones that modulates the frequency, rate or extent or transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
synonym: "regulation of transcription from Pol II promoter by pheromones" EXACT []
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0009373 ! regulation of transcription by pheromones

[Term]
id: GO:0046020
name: negative regulation of transcription from RNA polymerase II promoter by pheromones
namespace: biological_process
def: "Any process involving pheromones that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter." [GOC:go_curators]
synonym: "down regulation of transcription from RNA polymerase II promoter by pheromones" EXACT []
synonym: "down-regulation of transcription from RNA polymerase II promoter by pheromones" EXACT []
synonym: "downregulation of transcription from RNA polymerase II promoter by pheromones" EXACT []
synonym: "inhibition of transcription from RNA polymerase II promoter by pheromones" NARROW []
synonym: "negative regulation of transcription from Pol II promoter by pheromones" EXACT []
is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
is_a: GO:0045996 ! negative regulation of transcription by pheromones
is_a: GO:0046019 ! regulation of transcription from RNA polymerase II promoter by pheromones

[Term]
id: GO:0046021
name: regulation of transcription from RNA polymerase II promoter, mitotic
namespace: biological_process
def: "A cell cycle process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter during mitosis." [GOC:go_curators]
synonym: "mitotic regulation of transcription from Pol II promoter" EXACT []
synonym: "regulation of transcription from Pol II promoter, mitotic" EXACT []
synonym: "regulation of transcription from RNA polymerase II promoter during mitosis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0045896 ! regulation of transcription during mitosis
intersection_of: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
intersection_of: part_of GO:0007067 ! mitotic nuclear division
relationship: part_of GO:0007067 ! mitotic nuclear division

[Term]
id: GO:0046022
name: positive regulation of transcription from RNA polymerase II promoter during mitosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter during mitosis." [GOC:go_curators]
synonym: "activation of transcription from RNA polymerase II promoter during mitosis" NARROW [GOC:mah]
synonym: "mitotic activation of transcription from Pol II promoter" EXACT []
synonym: "positive regulation of transcription from Pol II promoter during mitosis" EXACT [GOC:mah]
synonym: "positive regulation of transcription from RNA polymerase II promoter, mitotic" EXACT [GOC:mah]
synonym: "stimulation of transcription from RNA polymerase II promoter during mitosis" NARROW [GOC:mah]
synonym: "up regulation of transcription from RNA polymerase II promoter during mitosis" EXACT [GOC:mah]
synonym: "up-regulation of transcription from RNA polymerase II promoter during mitosis" EXACT [GOC:mah]
synonym: "upregulation of transcription from RNA polymerase II promoter during mitosis" EXACT [GOC:mah]
is_a: GO:0045897 ! positive regulation of transcription during mitosis
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
is_a: GO:0046021 ! regulation of transcription from RNA polymerase II promoter, mitotic
intersection_of: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
intersection_of: part_of GO:0007067 ! mitotic nuclear division
relationship: part_of GO:0007067 ! mitotic nuclear division

[Term]
id: GO:0046023
name: regulation of transcription from RNA polymerase III promoter, mitotic
namespace: biological_process
def: "A cell cycle process that modulates the frequency, rate or extent of transcription from an RNA polymerase III promoter during mitosis." [GOC:go_curators]
synonym: "mitotic regulation of transcription from Pol III promoter" EXACT []
synonym: "regulation of transcription from Pol III promoter, mitotic" EXACT []
synonym: "regulation of transcription from RNA polymerase III promoter during mitosis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0006359 ! regulation of transcription from RNA polymerase III promoter
is_a: GO:0045896 ! regulation of transcription during mitosis
intersection_of: GO:0006359 ! regulation of transcription from RNA polymerase III promoter
intersection_of: part_of GO:0007067 ! mitotic nuclear division
relationship: part_of GO:0007067 ! mitotic nuclear division

[Term]
id: GO:0046024
name: positive regulation of transcription from RNA polymerase III promoter during mitosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase III promoter during mitosis." [GOC:go_curators]
synonym: "activation of transcription from RNA polymerase III promoter during mitosis" NARROW [GOC:mah]
synonym: "mitotic activation of transcription from Pol III promoter" EXACT []
synonym: "positive regulation of transcription from Pol III promoter during mitosis" EXACT [GOC:mah]
synonym: "positive regulation of transcription from RNA polymerase III promoter, mitotic" EXACT [GOC:mah]
synonym: "stimulation of transcription from RNA polymerase III promoter during mitosis" NARROW [GOC:mah]
synonym: "up regulation of transcription from RNA polymerase III promoter during mitosis" EXACT [GOC:mah]
synonym: "up-regulation of transcription from RNA polymerase III promoter during mitosis" EXACT [GOC:mah]
synonym: "upregulation of transcription from RNA polymerase III promoter during mitosis" EXACT [GOC:mah]
is_a: GO:0045897 ! positive regulation of transcription during mitosis
is_a: GO:0045945 ! positive regulation of transcription from RNA polymerase III promoter
is_a: GO:0046023 ! regulation of transcription from RNA polymerase III promoter, mitotic
intersection_of: GO:0045945 ! positive regulation of transcription from RNA polymerase III promoter
intersection_of: part_of GO:0007067 ! mitotic nuclear division
relationship: part_of GO:0007067 ! mitotic nuclear division

[Term]
id: GO:0046025
name: precorrin-6Y C5,15-methyltransferase (decarboxylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + precorrin-6Y = 2 S-adenosyl-L-homocysteine + precorrin-8X + CO2." [EC:2.1.1.132]
subset: gosubset_prok
synonym: "precorrin-6 methyltransferase activity" BROAD [EC:2.1.1.132]
synonym: "precorrin-6Y methylase activity" BROAD [EC:2.1.1.132]
synonym: "S-adenosyl-L-methionine:1-precorrin-6Y C5,15-methyltransferase (C-12-decarboxylating)" EXACT [EC:2.1.1.132]
xref: EC:2.1.1.132
xref: MetaCyc:2.1.1.132-RXN
xref: RHEA:17480
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0046026
name: precorrin-4 C11-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-4 = S-adenosyl-L-homocysteine + precorrin 5." [EC:2.1.1.133]
subset: gosubset_prok
synonym: "CobM" RELATED [EC:2.1.1.133]
synonym: "S-adenosyl-L-methionine:precorrin-4 C11 methyltransferase activity" EXACT [EC:2.1.1.133]
xref: EC:2.1.1.133
xref: MetaCyc:2.1.1.133-RXN
xref: RHEA:22015
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0046027
name: phospholipid:diacylglycerol acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: phospholipid + 1,2-diacylglycerol = lysophospholipid + triacylglycerol." [EC:2.3.1.158]
synonym: "PDAT activity" EXACT [EC:2.3.1.158]
synonym: "phospholipid:1,2-diacyl-sn-glycerol O-acyltransferase activity" EXACT [EC:2.3.1.158]
xref: EC:2.3.1.158
xref: MetaCyc:2.3.1.158-RXN
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0046028
name: electron transporter, transferring electrons from cytochrome b6/f complex of photosystem II activity
namespace: molecular_function
def: "Enables the directed movement of electrons from the cytochrome b6/f complex of photosystem II." [GOC:ai, ISBN:0716731363]
synonym: "plastocyanin" NARROW []
is_a: GO:0009055 ! electron carrier activity

[Term]
id: GO:0046029
name: mannitol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-mannitol + NAD(+) = D-mannose + H(+) + NADH." [EC:1.1.1.255, RHEA:15032]
synonym: "mannitol:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.255]
synonym: "MTD activity" EXACT [EC:1.1.1.255]
synonym: "NAD-dependent mannitol dehydrogenase activity" BROAD [EC:1.1.1.255]
xref: EC:1.1.1.255
xref: KEGG:R07135
xref: MetaCyc:1.1.1.255-RXN
xref: RHEA:15032
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
is_a: GO:0031320 ! hexitol dehydrogenase activity

[Term]
id: GO:0046030
name: inositol trisphosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: myo-inositol trisphosphate + H2O = myo-inositol bisphosphate + phosphate." [GOC:bf]
synonym: "inositol-1,4,5-trisphosphate phosphatase" NARROW []
synonym: "IP(3) phosphatase activity" EXACT []
synonym: "IP3 phosphatase activity" EXACT []
is_a: GO:0052745 ! inositol phosphate phosphatase activity

[Term]
id: GO:0046031
name: ADP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ADP, adenosine 5'-diphosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "ADP metabolism" EXACT []
is_a: GO:0009150 ! purine ribonucleotide metabolic process
is_a: GO:0009167 ! purine ribonucleoside monophosphate metabolic process
is_a: GO:0009179 ! purine ribonucleoside diphosphate metabolic process
is_a: GO:0046128 ! purine ribonucleoside metabolic process

[Term]
id: GO:0046032
name: ADP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ADP, adenosine 5'-diphosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "ADP breakdown" EXACT []
synonym: "ADP catabolism" EXACT []
synonym: "ADP degradation" EXACT []
is_a: GO:0009154 ! purine ribonucleotide catabolic process
is_a: GO:0009169 ! purine ribonucleoside monophosphate catabolic process
is_a: GO:0009181 ! purine ribonucleoside diphosphate catabolic process
is_a: GO:0046031 ! ADP metabolic process
is_a: GO:0046130 ! purine ribonucleoside catabolic process

[Term]
id: GO:0046033
name: AMP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving AMP, adenosine monophosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "adenylate forming enzyme activity" RELATED []
synonym: "AMP metabolism" EXACT []
is_a: GO:0009150 ! purine ribonucleotide metabolic process
is_a: GO:0009167 ! purine ribonucleoside monophosphate metabolic process
is_a: GO:0046128 ! purine ribonucleoside metabolic process

[Term]
id: GO:0046034
name: ATP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators]
subset: goslim_metagenomics
subset: gosubset_prok
synonym: "ATP metabolism" EXACT []
is_a: GO:0009150 ! purine ribonucleotide metabolic process
is_a: GO:0009167 ! purine ribonucleoside monophosphate metabolic process
is_a: GO:0009205 ! purine ribonucleoside triphosphate metabolic process
is_a: GO:0046128 ! purine ribonucleoside metabolic process

[Term]
id: GO:0046035
name: CMP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving CMP, cytidine monophosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "CMP metabolism" EXACT []
is_a: GO:0009173 ! pyrimidine ribonucleoside monophosphate metabolic process
is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process
is_a: GO:0046131 ! pyrimidine ribonucleoside metabolic process

[Term]
id: GO:0046036
name: CTP metabolic process
namespace: biological_process
alt_id: GO:0006243
def: "The chemical reactions and pathways involving CTP, cytidine triphosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "CTP deamination" NARROW []
synonym: "CTP metabolism" EXACT []
is_a: GO:0009208 ! pyrimidine ribonucleoside triphosphate metabolic process
is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process
is_a: GO:0046131 ! pyrimidine ribonucleoside metabolic process

[Term]
id: GO:0046037
name: GMP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving GMP, guanosine monophosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "GMP metabolism" EXACT []
is_a: GO:0009150 ! purine ribonucleotide metabolic process
is_a: GO:0009167 ! purine ribonucleoside monophosphate metabolic process
is_a: GO:1901068 ! guanosine-containing compound metabolic process

[Term]
id: GO:0046038
name: GMP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of GMP, guanosine monophosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "GMP breakdown" EXACT []
synonym: "GMP catabolism" EXACT []
synonym: "GMP degradation" EXACT []
is_a: GO:0009154 ! purine ribonucleotide catabolic process
is_a: GO:0009169 ! purine ribonucleoside monophosphate catabolic process
is_a: GO:0046037 ! GMP metabolic process
is_a: GO:1901069 ! guanosine-containing compound catabolic process

[Term]
id: GO:0046039
name: GTP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving GTP, guanosine triphosphate." [GOC:go_curators]
subset: goslim_metagenomics
subset: gosubset_prok
synonym: "GTP metabolism" EXACT []
is_a: GO:0009150 ! purine ribonucleotide metabolic process
is_a: GO:0009205 ! purine ribonucleoside triphosphate metabolic process
is_a: GO:1901068 ! guanosine-containing compound metabolic process

[Term]
id: GO:0046040
name: IMP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving IMP, inosine monophosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "IMP metabolism" EXACT []
is_a: GO:0009150 ! purine ribonucleotide metabolic process
is_a: GO:0009167 ! purine ribonucleoside monophosphate metabolic process

[Term]
id: GO:0046041
name: ITP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ITP, inosine triphosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "ITP metabolism" EXACT []
is_a: GO:0009150 ! purine ribonucleotide metabolic process
is_a: GO:0009205 ! purine ribonucleoside triphosphate metabolic process

[Term]
id: GO:0046042
name: ITP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ITP, inosine triphosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "ITP anabolism" EXACT []
synonym: "ITP biosynthesis" EXACT []
synonym: "ITP formation" EXACT []
synonym: "ITP synthesis" EXACT []
is_a: GO:0009152 ! purine ribonucleotide biosynthetic process
is_a: GO:0009206 ! purine ribonucleoside triphosphate biosynthetic process
is_a: GO:0046041 ! ITP metabolic process

[Term]
id: GO:0046043
name: TDP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving TDP, ribosylthymine diphosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "TDP metabolism" EXACT []
is_a: GO:0009193 ! pyrimidine ribonucleoside diphosphate metabolic process
is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process

[Term]
id: GO:0046044
name: TMP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving TMP, ribosylthymine monophosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "TMP metabolism" EXACT []
is_a: GO:0009173 ! pyrimidine ribonucleoside monophosphate metabolic process
is_a: GO:0009176 ! pyrimidine deoxyribonucleoside monophosphate metabolic process
is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process
is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process

[Term]
id: GO:0046045
name: TMP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of TMP, ribosylthymine monophosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "TMP breakdown" EXACT []
synonym: "TMP catabolism" EXACT []
synonym: "TMP degradation" EXACT []
is_a: GO:0009175 ! pyrimidine ribonucleoside monophosphate catabolic process
is_a: GO:0009178 ! pyrimidine deoxyribonucleoside monophosphate catabolic process
is_a: GO:0009222 ! pyrimidine ribonucleotide catabolic process
is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process
is_a: GO:0046044 ! TMP metabolic process

[Term]
id: GO:0046046
name: TTP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving TTP, ribosylthymine triphosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "TTP metabolism" EXACT []
is_a: GO:0009208 ! pyrimidine ribonucleoside triphosphate metabolic process
is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process

[Term]
id: GO:0046047
name: TTP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of TTP, ribosylthymine triphosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "TTP breakdown" EXACT []
synonym: "TTP catabolism" EXACT []
synonym: "TTP degradation" EXACT []
synonym: "TTP hydrolysis" EXACT []
is_a: GO:0009210 ! pyrimidine ribonucleoside triphosphate catabolic process
is_a: GO:0009222 ! pyrimidine ribonucleotide catabolic process
is_a: GO:0046046 ! TTP metabolic process

[Term]
id: GO:0046048
name: UDP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving UDP, uridine (5'-)diphosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "UDP metabolism" EXACT []
is_a: GO:0009193 ! pyrimidine ribonucleoside diphosphate metabolic process
is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process
is_a: GO:0046131 ! pyrimidine ribonucleoside metabolic process

[Term]
id: GO:0046049
name: UMP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving UMP, uridine monophosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "UMP metabolism" EXACT []
is_a: GO:0009173 ! pyrimidine ribonucleoside monophosphate metabolic process
is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process
is_a: GO:0046131 ! pyrimidine ribonucleoside metabolic process

[Term]
id: GO:0046050
name: UMP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of UMP, uridine monophosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "UMP breakdown" EXACT []
synonym: "UMP catabolism" EXACT []
synonym: "UMP degradation" EXACT []
is_a: GO:0009175 ! pyrimidine ribonucleoside monophosphate catabolic process
is_a: GO:0009222 ! pyrimidine ribonucleotide catabolic process
is_a: GO:0046049 ! UMP metabolic process
is_a: GO:0046133 ! pyrimidine ribonucleoside catabolic process

[Term]
id: GO:0046051
name: UTP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving UTP, uridine (5'-)triphosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "UTP metabolism" EXACT []
is_a: GO:0009208 ! pyrimidine ribonucleoside triphosphate metabolic process
is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process
is_a: GO:0046131 ! pyrimidine ribonucleoside metabolic process

[Term]
id: GO:0046052
name: UTP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of UTP, uridine (5'-)triphosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "UTP breakdown" EXACT []
synonym: "UTP catabolism" EXACT []
synonym: "UTP degradation" EXACT []
synonym: "UTP hydrolysis" EXACT []
is_a: GO:0009210 ! pyrimidine ribonucleoside triphosphate catabolic process
is_a: GO:0009222 ! pyrimidine ribonucleotide catabolic process
is_a: GO:0046051 ! UTP metabolic process
is_a: GO:0046133 ! pyrimidine ribonucleoside catabolic process

[Term]
id: GO:0046053
name: dAMP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dAMP, deoxyadenosine monophosphate (2'-deoxyadenosine 5'-phosphate)." [GOC:go_curators]
subset: gosubset_prok
synonym: "dAMP metabolism" EXACT []
is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process
is_a: GO:0009170 ! purine deoxyribonucleoside monophosphate metabolic process

[Term]
id: GO:0046054
name: dGMP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dGMP, deoxyguanosine monophosphate (2'-deoxyguanosine 5'-phosphate)." [GOC:go_curators]
subset: gosubset_prok
synonym: "dGMP metabolism" EXACT []
is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process
is_a: GO:0009170 ! purine deoxyribonucleoside monophosphate metabolic process

[Term]
id: GO:0046055
name: dGMP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dGMP, deoxyguanosine monophosphate (2'-deoxyguanosine 5'-phosphate)." [GOC:go_curators]
subset: gosubset_prok
synonym: "dGMP breakdown" EXACT []
synonym: "dGMP catabolism" EXACT []
synonym: "dGMP degradation" EXACT []
is_a: GO:0009155 ! purine deoxyribonucleotide catabolic process
is_a: GO:0009172 ! purine deoxyribonucleoside monophosphate catabolic process
is_a: GO:0046054 ! dGMP metabolic process

[Term]
id: GO:0046056
name: dADP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dADP, deoxyadenosine diphosphate (2'-deoxyadenosine 5'-diphosphate)." [GOC:go_curators]
subset: gosubset_prok
synonym: "dADP metabolism" EXACT []
is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process
is_a: GO:0009182 ! purine deoxyribonucleoside diphosphate metabolic process

[Term]
id: GO:0046057
name: dADP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dADP, deoxyadenosine diphosphate (2'-deoxyadenosine 5'-diphosphate)." [GOC:go_curators]
subset: gosubset_prok
synonym: "dADP breakdown" EXACT []
synonym: "dADP catabolism" EXACT []
synonym: "dADP degradation" EXACT []
is_a: GO:0009155 ! purine deoxyribonucleotide catabolic process
is_a: GO:0009184 ! purine deoxyribonucleoside diphosphate catabolic process
is_a: GO:0046056 ! dADP metabolic process

[Term]
id: GO:0046058
name: cAMP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:go_curators]
subset: gosubset_prok
synonym: "3',5' cAMP metabolic process" EXACT []
synonym: "3',5' cAMP metabolism" EXACT []
synonym: "3',5'-cAMP metabolic process" EXACT []
synonym: "3',5'-cAMP metabolism" EXACT []
synonym: "adenosine 3',5'-cyclophosphate metabolic process" EXACT []
synonym: "adenosine 3',5'-cyclophosphate metabolism" EXACT []
synonym: "cAMP generating peptide activity" RELATED []
synonym: "cAMP metabolism" EXACT []
synonym: "cyclic AMP metabolic process" EXACT []
synonym: "cyclic AMP metabolism" EXACT []
is_a: GO:0009150 ! purine ribonucleotide metabolic process
is_a: GO:0009187 ! cyclic nucleotide metabolic process

[Term]
id: GO:0046059
name: dAMP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dAMP, deoxyadenosine monophosphate (2'-deoxyadenosine 5'-phosphate)." [GOC:go_curators]
subset: gosubset_prok
synonym: "dAMP breakdown" EXACT []
synonym: "dAMP catabolism" EXACT []
synonym: "dAMP degradation" EXACT []
is_a: GO:0009155 ! purine deoxyribonucleotide catabolic process
is_a: GO:0009172 ! purine deoxyribonucleoside monophosphate catabolic process
is_a: GO:0046053 ! dAMP metabolic process

[Term]
id: GO:0046060
name: dATP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate)." [GOC:go_curators]
subset: gosubset_prok
synonym: "dATP metabolism" EXACT []
is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process
is_a: GO:0009215 ! purine deoxyribonucleoside triphosphate metabolic process

[Term]
id: GO:0046061
name: dATP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate)." [GOC:go_curators]
subset: gosubset_prok
synonym: "dATP breakdown" EXACT []
synonym: "dATP catabolism" EXACT []
synonym: "dATP degradation" EXACT []
is_a: GO:0009155 ! purine deoxyribonucleotide catabolic process
is_a: GO:0009217 ! purine deoxyribonucleoside triphosphate catabolic process
is_a: GO:0046060 ! dATP metabolic process

[Term]
id: GO:0046062
name: dCDP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dCDP, deoxycytidine 5'-diphosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "dCDP metabolism" EXACT []
is_a: GO:0009196 ! pyrimidine deoxyribonucleoside diphosphate metabolic process
is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process

[Term]
id: GO:0046063
name: dCMP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dCMP, deoxycytidine monophosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "dCMP metabolism" EXACT []
is_a: GO:0009176 ! pyrimidine deoxyribonucleoside monophosphate metabolic process
is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process

[Term]
id: GO:0046064
name: dCMP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dCMP, deoxycytidine monophosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "dCMP anabolism" EXACT []
synonym: "dCMP biosynthesis" EXACT []
synonym: "dCMP formation" EXACT []
synonym: "dCMP synthesis" EXACT []
is_a: GO:0009177 ! pyrimidine deoxyribonucleoside monophosphate biosynthetic process
is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process
is_a: GO:0046063 ! dCMP metabolic process

[Term]
id: GO:0046065
name: dCTP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dCTP, deoxycytidine triphosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "dCTP metabolism" EXACT []
is_a: GO:0009211 ! pyrimidine deoxyribonucleoside triphosphate metabolic process
is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process

[Term]
id: GO:0046066
name: dGDP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dGDP, deoxyguanosine diphosphate, (2'-deoxyguanosine 5'-diphosphate)." [GOC:go_curators]
subset: gosubset_prok
synonym: "dGDP metabolism" EXACT []
is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process
is_a: GO:0009182 ! purine deoxyribonucleoside diphosphate metabolic process

[Term]
id: GO:0046067
name: dGDP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dGDP, deoxyguanosine diphosphate, (2'-deoxyguanosine 5'-diphosphate)." [GOC:go_curators]
subset: gosubset_prok
synonym: "dGDP breakdown" EXACT []
synonym: "dGDP catabolism" EXACT []
synonym: "dGDP degradation" EXACT []
is_a: GO:0009155 ! purine deoxyribonucleotide catabolic process
is_a: GO:0009184 ! purine deoxyribonucleoside diphosphate catabolic process
is_a: GO:0046066 ! dGDP metabolic process

[Term]
id: GO:0046068
name: cGMP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cyclic GMP, guanosine 3',5'-phosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "cGMP metabolism" EXACT []
is_a: GO:0009150 ! purine ribonucleotide metabolic process
is_a: GO:0009187 ! cyclic nucleotide metabolic process

[Term]
id: GO:0046069
name: cGMP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cyclic GMP, guanosine 3',5'-phosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "cGMP breakdown" EXACT []
synonym: "cGMP catabolism" EXACT []
synonym: "cGMP degradation" EXACT []
is_a: GO:0009154 ! purine ribonucleotide catabolic process
is_a: GO:0009214 ! cyclic nucleotide catabolic process
is_a: GO:0046068 ! cGMP metabolic process

[Term]
id: GO:0046070
name: dGTP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dGTP, guanosine triphosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "dGTP metabolism" EXACT []
is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process
is_a: GO:0009215 ! purine deoxyribonucleoside triphosphate metabolic process

[Term]
id: GO:0046071
name: dGTP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dGTP, guanosine triphosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "dGTP anabolism" EXACT []
synonym: "dGTP biosynthesis" EXACT []
synonym: "dGTP formation" EXACT []
synonym: "dGTP synthesis" EXACT []
is_a: GO:0009153 ! purine deoxyribonucleotide biosynthetic process
is_a: GO:0009216 ! purine deoxyribonucleoside triphosphate biosynthetic process
is_a: GO:0046070 ! dGTP metabolic process

[Term]
id: GO:0046072
name: dTDP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dTDP, deoxyribosylthymine diphosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "dTDP metabolism" EXACT []
is_a: GO:0009196 ! pyrimidine deoxyribonucleoside diphosphate metabolic process
is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process

[Term]
id: GO:0046073
name: dTMP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate)." [GOC:go_curators]
subset: gosubset_prok
synonym: "dTMP metabolism" EXACT []
is_a: GO:0009176 ! pyrimidine deoxyribonucleoside monophosphate metabolic process
is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process

[Term]
id: GO:0046074
name: dTMP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dTMP, deoxyribosylthymine monophosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "dTMP breakdown" EXACT []
synonym: "dTMP catabolism" EXACT []
synonym: "dTMP degradation" EXACT []
is_a: GO:0009178 ! pyrimidine deoxyribonucleoside monophosphate catabolic process
is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process
is_a: GO:0046073 ! dTMP metabolic process

[Term]
id: GO:0046075
name: dTTP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dTTP, deoxyribosylthymine triphosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "dTTP metabolism" EXACT []
is_a: GO:0009211 ! pyrimidine deoxyribonucleoside triphosphate metabolic process
is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process

[Term]
id: GO:0046076
name: dTTP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dTTP, deoxyribosylthymine triphosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "dTTP breakdown" EXACT []
synonym: "dTTP catabolism" EXACT []
synonym: "dTTP degradation" EXACT []
is_a: GO:0009213 ! pyrimidine deoxyribonucleoside triphosphate catabolic process
is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process
is_a: GO:0046075 ! dTTP metabolic process

[Term]
id: GO:0046077
name: dUDP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dUDP, deoxyuridine (5'-)diphosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "dUDP metabolism" EXACT []
is_a: GO:0009196 ! pyrimidine deoxyribonucleoside diphosphate metabolic process
is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process

[Term]
id: GO:0046078
name: dUMP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dUMP, deoxyuridine (5'-)monophosphate (2'-deoxyuridine 5'-phosphate)." [GOC:go_curators]
subset: gosubset_prok
synonym: "dUMP metabolism" EXACT []
is_a: GO:0009176 ! pyrimidine deoxyribonucleoside monophosphate metabolic process
is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process

[Term]
id: GO:0046079
name: dUMP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dUMP, deoxyuridine (5'-)monophosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "dUMP breakdown" EXACT []
synonym: "dUMP catabolism" EXACT []
synonym: "dUMP degradation" EXACT []
is_a: GO:0009178 ! pyrimidine deoxyribonucleoside monophosphate catabolic process
is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process
is_a: GO:0046078 ! dUMP metabolic process

[Term]
id: GO:0046080
name: dUTP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dUTP, deoxyuridine (5'-)triphosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "dUTP metabolism" EXACT []
is_a: GO:0009211 ! pyrimidine deoxyribonucleoside triphosphate metabolic process
is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process

[Term]
id: GO:0046081
name: dUTP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dUTP, deoxyuridine (5'-)triphosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "dUTP breakdown" EXACT []
synonym: "dUTP catabolism" EXACT []
synonym: "dUTP degradation" EXACT []
is_a: GO:0009213 ! pyrimidine deoxyribonucleoside triphosphate catabolic process
is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process
is_a: GO:0046080 ! dUTP metabolic process

[Term]
id: GO:0046082
name: 5-methylcytosine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 5-methylcytosine, a methylated base of DNA." [GOC:go_curators]
subset: gosubset_prok
synonym: "5-methylcytosine anabolism" EXACT []
synonym: "5-methylcytosine biosynthesis" EXACT []
synonym: "5-methylcytosine formation" EXACT []
synonym: "5-methylcytosine synthesis" EXACT []
is_a: GO:0019857 ! 5-methylcytosine metabolic process
is_a: GO:0072528 ! pyrimidine-containing compound biosynthetic process

[Term]
id: GO:0046083
name: adenine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving adenine, 6-aminopurine, one of the five main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine." [GOC:go_curators]
subset: gosubset_prok
synonym: "adenine metabolism" EXACT []
is_a: GO:0006144 ! purine nucleobase metabolic process

[Term]
id: GO:0046084
name: adenine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of adenine, 6-aminopurine, one of the five main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine." [GOC:go_curators]
subset: gosubset_prok
synonym: "adenine anabolism" EXACT []
synonym: "adenine biosynthesis" EXACT []
synonym: "adenine formation" EXACT []
synonym: "adenine synthesis" EXACT []
is_a: GO:0009113 ! purine nucleobase biosynthetic process
is_a: GO:0046083 ! adenine metabolic process

[Term]
id: GO:0046085
name: adenosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes." [GOC:go_curators]
subset: gosubset_prok
synonym: "adenosine metabolism" EXACT []
is_a: GO:0046128 ! purine ribonucleoside metabolic process

[Term]
id: GO:0046086
name: adenosine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes." [GOC:go_curators]
subset: gosubset_prok
synonym: "adenosine anabolism" EXACT []
synonym: "adenosine biosynthesis" EXACT []
synonym: "adenosine formation" EXACT []
synonym: "adenosine synthesis" EXACT []
is_a: GO:0046085 ! adenosine metabolic process
is_a: GO:0046129 ! purine ribonucleoside biosynthetic process

[Term]
id: GO:0046087
name: cytidine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cytidine, cytosine riboside, a widely distributed nucleoside." [GOC:go_curators]
subset: gosubset_prok
synonym: "cytidine metabolism" EXACT []
is_a: GO:0046131 ! pyrimidine ribonucleoside metabolic process

[Term]
id: GO:0046088
name: cytidine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cytidine, cytosine riboside, a widely distributed nucleoside." [GOC:go_curators]
subset: gosubset_prok
synonym: "cytidine anabolism" EXACT []
synonym: "cytidine biosynthesis" EXACT []
synonym: "cytidine formation" EXACT []
synonym: "cytidine synthesis" EXACT []
is_a: GO:0046087 ! cytidine metabolic process
is_a: GO:0046132 ! pyrimidine ribonucleoside biosynthetic process

[Term]
id: GO:0046089
name: cytosine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cytosine, 4-amino-2-hydroxypyrimidine, a pyrimidine derivative that is one of the five main bases found in nucleic acids; it occurs widely in cytidine derivatives." [GOC:go_curators]
subset: gosubset_prok
synonym: "cytosine anabolism" EXACT []
synonym: "cytosine biosynthesis" EXACT []
synonym: "cytosine formation" EXACT []
synonym: "cytosine synthesis" EXACT []
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0019856 ! pyrimidine nucleobase biosynthetic process
is_a: GO:0019858 ! cytosine metabolic process

[Term]
id: GO:0046090
name: deoxyadenosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving deoxyadenosine, 2-deoxyribosyladenine, one of the four major nucleosides of DNA." [GOC:go_curators]
subset: gosubset_prok
synonym: "deoxyadenosine metabolism" EXACT []
is_a: GO:0046122 ! purine deoxyribonucleoside metabolic process

[Term]
id: GO:0046091
name: deoxyadenosine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of deoxyadenosine, 2-deoxyribosyladenine, one of the four major nucleosides of DNA." [GOC:go_curators]
subset: gosubset_prok
synonym: "deoxyadenosine anabolism" EXACT []
synonym: "deoxyadenosine biosynthesis" EXACT []
synonym: "deoxyadenosine formation" EXACT []
synonym: "deoxyadenosine synthesis" EXACT []
is_a: GO:0046090 ! deoxyadenosine metabolic process
is_a: GO:0046123 ! purine deoxyribonucleoside biosynthetic process

[Term]
id: GO:0046092
name: deoxycytidine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving deoxycytidine, 2-deoxyribosylcytosine, one of the four major nucleosides of DNA." [GOC:go_curators]
subset: gosubset_prok
synonym: "deoxycytidine metabolism" EXACT []
is_a: GO:0046125 ! pyrimidine deoxyribonucleoside metabolic process

[Term]
id: GO:0046093
name: deoxycytidine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of deoxycytidine, 2-deoxyribosylcytosine, one of the four major nucleosides of DNA." [GOC:go_curators]
subset: gosubset_prok
synonym: "deoxycytidine anabolism" EXACT []
synonym: "deoxycytidine biosynthesis" EXACT []
synonym: "deoxycytidine formation" EXACT []
synonym: "deoxycytidine synthesis" EXACT []
is_a: GO:0046092 ! deoxycytidine metabolic process
is_a: GO:0046126 ! pyrimidine deoxyribonucleoside biosynthetic process

[Term]
id: GO:0046094
name: deoxyinosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving deoxyinosine, hypoxanthine deoxyriboside." [GOC:go_curators]
subset: gosubset_prok
synonym: "deoxyinosine metabolism" EXACT []
is_a: GO:0046122 ! purine deoxyribonucleoside metabolic process

[Term]
id: GO:0046095
name: deoxyinosine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of deoxyinosine, hypoxanthine deoxyriboside." [GOC:go_curators]
subset: gosubset_prok
synonym: "deoxyinosine anabolism" EXACT []
synonym: "deoxyinosine biosynthesis" EXACT []
synonym: "deoxyinosine formation" EXACT []
synonym: "deoxyinosine synthesis" EXACT []
is_a: GO:0046094 ! deoxyinosine metabolic process
is_a: GO:0046123 ! purine deoxyribonucleoside biosynthetic process

[Term]
id: GO:0046096
name: deoxyuridine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving deoxyuridine, 2-deoxyribosyluracil, one of the four major nucleosides of DNA." [GOC:go_curators]
subset: gosubset_prok
synonym: "deoxyuridine metabolism" EXACT []
is_a: GO:0046125 ! pyrimidine deoxyribonucleoside metabolic process

[Term]
id: GO:0046097
name: deoxyuridine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of deoxyuridine, 2-deoxyribosyluracil, one of the four major nucleosides of DNA." [GOC:go_curators]
subset: gosubset_prok
synonym: "deoxyuridine anabolism" EXACT []
synonym: "deoxyuridine biosynthesis" EXACT []
synonym: "deoxyuridine formation" EXACT []
synonym: "deoxyuridine synthesis" EXACT []
is_a: GO:0046096 ! deoxyuridine metabolic process
is_a: GO:0046126 ! pyrimidine deoxyribonucleoside biosynthetic process

[Term]
id: GO:0046098
name: guanine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important." [GOC:go_curators]
subset: gosubset_prok
synonym: "guanine metabolism" EXACT []
is_a: GO:0006144 ! purine nucleobase metabolic process

[Term]
id: GO:0046099
name: guanine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important." [GOC:go_curators]
subset: gosubset_prok
synonym: "guanine anabolism" EXACT []
synonym: "guanine biosynthesis" EXACT []
synonym: "guanine formation" EXACT []
synonym: "guanine synthesis" EXACT []
is_a: GO:0009113 ! purine nucleobase biosynthetic process
is_a: GO:0046098 ! guanine metabolic process

[Term]
id: GO:0046100
name: hypoxanthine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate." [GOC:go_curators]
subset: gosubset_prok
synonym: "hypoxanthine metabolism" EXACT []
is_a: GO:0006144 ! purine nucleobase metabolic process

[Term]
id: GO:0046101
name: hypoxanthine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate." [GOC:go_curators]
subset: gosubset_prok
synonym: "hypoxanthine anabolism" EXACT []
synonym: "hypoxanthine biosynthesis" EXACT []
synonym: "hypoxanthine formation" EXACT []
synonym: "hypoxanthine synthesis" EXACT []
is_a: GO:0009113 ! purine nucleobase biosynthetic process
is_a: GO:0046100 ! hypoxanthine metabolic process

[Term]
id: GO:0046102
name: inosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs." [GOC:go_curators]
subset: gosubset_prok
synonym: "inosine metabolism" EXACT []
is_a: GO:0046128 ! purine ribonucleoside metabolic process

[Term]
id: GO:0046103
name: inosine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs." [GOC:go_curators]
subset: gosubset_prok
synonym: "inosine anabolism" EXACT []
synonym: "inosine biosynthesis" EXACT []
synonym: "inosine formation" EXACT []
synonym: "inosine synthesis" EXACT []
is_a: GO:0046102 ! inosine metabolic process
is_a: GO:0046129 ! purine ribonucleoside biosynthetic process

[Term]
id: GO:0046104
name: thymidine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA." [GOC:go_curators]
subset: gosubset_prok
synonym: "deoxyribosylthymine metabolic process" EXACT []
synonym: "deoxyribosylthymine metabolism" EXACT []
synonym: "thymidine metabolism" EXACT []
is_a: GO:0046125 ! pyrimidine deoxyribonucleoside metabolic process

[Term]
id: GO:0046105
name: thymidine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA." [GOC:go_curators]
subset: gosubset_prok
synonym: "deoxyribosylthymine biosynthesis" EXACT []
synonym: "deoxyribosylthymine biosynthetic process" EXACT []
synonym: "thymidine anabolism" EXACT []
synonym: "thymidine biosynthesis" EXACT []
synonym: "thymidine formation" EXACT []
synonym: "thymidine synthesis" EXACT []
is_a: GO:0046104 ! thymidine metabolic process
is_a: GO:0046126 ! pyrimidine deoxyribonucleoside biosynthetic process

[Term]
id: GO:0046106
name: thymine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base." [GOC:go_curators]
subset: gosubset_prok
synonym: "thymine anabolism" EXACT []
synonym: "thymine biosynthesis" EXACT []
synonym: "thymine formation" EXACT []
synonym: "thymine synthesis" EXACT []
is_a: GO:0019856 ! pyrimidine nucleobase biosynthetic process
is_a: GO:0019859 ! thymine metabolic process

[Term]
id: GO:0046107
name: uracil biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA." [GOC:go_curators]
subset: gosubset_prok
synonym: "uracil anabolism" EXACT []
synonym: "uracil biosynthesis" EXACT []
synonym: "uracil formation" EXACT []
synonym: "uracil synthesis" EXACT []
is_a: GO:0019856 ! pyrimidine nucleobase biosynthetic process
is_a: GO:0019860 ! uracil metabolic process

[Term]
id: GO:0046108
name: uridine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids." [GOC:go_curators]
subset: gosubset_prok
synonym: "uridine metabolism" EXACT []
is_a: GO:0046131 ! pyrimidine ribonucleoside metabolic process

[Term]
id: GO:0046109
name: uridine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids." [GOC:go_curators]
subset: gosubset_prok
synonym: "uridine anabolism" EXACT []
synonym: "uridine biosynthesis" EXACT []
synonym: "uridine formation" EXACT []
synonym: "uridine synthesis" EXACT []
is_a: GO:0046108 ! uridine metabolic process
is_a: GO:0046132 ! pyrimidine ribonucleoside biosynthetic process

[Term]
id: GO:0046110
name: xanthine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids." [GOC:go_curators]
subset: gosubset_prok
synonym: "xanthine metabolism" EXACT []
is_a: GO:0006144 ! purine nucleobase metabolic process

[Term]
id: GO:0046111
name: xanthine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids." [GOC:go_curators]
subset: gosubset_prok
synonym: "xanthine anabolism" EXACT []
synonym: "xanthine biosynthesis" EXACT []
synonym: "xanthine formation" EXACT []
synonym: "xanthine synthesis" EXACT []
is_a: GO:0009113 ! purine nucleobase biosynthetic process
is_a: GO:0046110 ! xanthine metabolic process

[Term]
id: GO:0046112
name: nucleobase biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid." [GOC:ai]
subset: gosubset_prok
synonym: "nucleobase anabolism" EXACT []
synonym: "nucleobase biosynthesis" EXACT []
synonym: "nucleobase formation" EXACT []
synonym: "nucleobase synthesis" EXACT []
is_a: GO:0009112 ! nucleobase metabolic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process

[Term]
id: GO:0046113
name: nucleobase catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid." [GOC:ai]
subset: gosubset_prok
synonym: "nucleobase breakdown" EXACT []
synonym: "nucleobase catabolism" EXACT []
synonym: "nucleobase degradation" EXACT []
is_a: GO:0009112 ! nucleobase metabolic process
is_a: GO:0044712 ! single-organism catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process

[Term]
id: GO:0046114
name: guanosine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of guanine, guanine riboside, a nucleoside with a wide species distribution." [GOC:go_curators]
subset: gosubset_prok
synonym: "guanosine anabolism" EXACT []
synonym: "guanosine biosynthesis" EXACT []
synonym: "guanosine formation" EXACT []
synonym: "guanosine synthesis" EXACT []
is_a: GO:0008617 ! guanosine metabolic process
is_a: GO:1901070 ! guanosine-containing compound biosynthetic process

[Term]
id: GO:0046115
name: guanosine catabolic process
namespace: biological_process
alt_id: GO:0006160
def: "The chemical reactions and pathways resulting in the breakdown of guanine, guanine riboside, a nucleoside with a wide species distribution." [GOC:go_curators]
subset: gosubset_prok
synonym: "guanosine breakdown" EXACT []
synonym: "guanosine catabolism" EXACT []
synonym: "guanosine degradation" EXACT []
synonym: "guanosine phosphorolysis" RELATED []
is_a: GO:0008617 ! guanosine metabolic process
is_a: GO:1901069 ! guanosine-containing compound catabolic process

[Term]
id: GO:0046116
name: queuosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving queuosines, any of a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents." [ISBN:0198506732]
subset: gosubset_prok
synonym: "queuosine metabolism" EXACT []
is_a: GO:0009119 ! ribonucleoside metabolic process

[Term]
id: GO:0046117
name: queuosine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of queuosines, any of a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents." [ISBN:0198506732]
subset: gosubset_prok
synonym: "queuosine breakdown" EXACT []
synonym: "queuosine catabolism" EXACT []
synonym: "queuosine degradation" EXACT []
is_a: GO:0042454 ! ribonucleoside catabolic process
is_a: GO:0046116 ! queuosine metabolic process

[Term]
id: GO:0046118
name: 7-methylguanosine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 7-methylguanosine, a modified nucleoside that forms a cap at the 5'-terminus of eukaryotic mRNA." [ISBN:0198506732]
subset: gosubset_prok
synonym: "7-methylguanosine anabolism" EXACT []
synonym: "7-methylguanosine biosynthesis" EXACT []
synonym: "7-methylguanosine formation" EXACT []
synonym: "7-methylguanosine synthesis" EXACT []
is_a: GO:0008618 ! 7-methylguanosine metabolic process
is_a: GO:1901070 ! guanosine-containing compound biosynthetic process

[Term]
id: GO:0046119
name: 7-methylguanosine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 7-methylguanosine, a modified nucleoside that forms a cap at the 5'-terminus of eukaryotic mRNA." [ISBN:0198506732]
subset: gosubset_prok
synonym: "7-methylguanosine breakdown" EXACT []
synonym: "7-methylguanosine catabolism" EXACT []
synonym: "7-methylguanosine degradation" EXACT []
is_a: GO:0008618 ! 7-methylguanosine metabolic process
is_a: GO:1901069 ! guanosine-containing compound catabolic process

[Term]
id: GO:0046120
name: deoxyribonucleoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai]
subset: gosubset_prok
synonym: "deoxyribonucleoside anabolism" EXACT []
synonym: "deoxyribonucleoside biosynthesis" EXACT []
synonym: "deoxyribonucleoside formation" EXACT []
synonym: "deoxyribonucleoside synthesis" EXACT []
is_a: GO:0009120 ! deoxyribonucleoside metabolic process
is_a: GO:0009163 ! nucleoside biosynthetic process

[Term]
id: GO:0046121
name: deoxyribonucleoside catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai]
subset: gosubset_prok
synonym: "deoxyribonucleoside breakdown" EXACT []
synonym: "deoxyribonucleoside catabolism" EXACT []
synonym: "deoxyribonucleoside degradation" EXACT []
is_a: GO:0009120 ! deoxyribonucleoside metabolic process
is_a: GO:0009164 ! nucleoside catabolic process

[Term]
id: GO:0046122
name: purine deoxyribonucleoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any one of a family of organic molecules consisting of a purine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai]
subset: gosubset_prok
synonym: "purine deoxyribonucleoside metabolism" EXACT []
is_a: GO:0009120 ! deoxyribonucleoside metabolic process
is_a: GO:0042278 ! purine nucleoside metabolic process

[Term]
id: GO:0046123
name: purine deoxyribonucleoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any purine deoxyribonucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai]
subset: gosubset_prok
synonym: "purine deoxyribonucleoside anabolism" EXACT []
synonym: "purine deoxyribonucleoside biosynthesis" EXACT []
synonym: "purine deoxyribonucleoside formation" EXACT []
synonym: "purine deoxyribonucleoside synthesis" EXACT []
is_a: GO:0042451 ! purine nucleoside biosynthetic process
is_a: GO:0046120 ! deoxyribonucleoside biosynthetic process
is_a: GO:0046122 ! purine deoxyribonucleoside metabolic process

[Term]
id: GO:0046124
name: purine deoxyribonucleoside catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any one of a family of organic molecules consisting of a purine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai]
subset: gosubset_prok
synonym: "purine deoxyribonucleoside breakdown" EXACT []
synonym: "purine deoxyribonucleoside catabolism" EXACT []
synonym: "purine deoxyribonucleoside degradation" EXACT []
is_a: GO:0006152 ! purine nucleoside catabolic process
is_a: GO:0046121 ! deoxyribonucleoside catabolic process
is_a: GO:0046122 ! purine deoxyribonucleoside metabolic process

[Term]
id: GO:0046125
name: pyrimidine deoxyribonucleoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai]
subset: gosubset_prok
synonym: "pyrimidine deoxyribonucleoside metabolism" EXACT []
is_a: GO:0006213 ! pyrimidine nucleoside metabolic process
is_a: GO:0009120 ! deoxyribonucleoside metabolic process

[Term]
id: GO:0046126
name: pyrimidine deoxyribonucleoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai]
subset: gosubset_prok
synonym: "pyrimidine deoxyribonucleoside anabolism" EXACT []
synonym: "pyrimidine deoxyribonucleoside biosynthesis" EXACT []
synonym: "pyrimidine deoxyribonucleoside formation" EXACT []
synonym: "pyrimidine deoxyribonucleoside synthesis" EXACT []
is_a: GO:0046120 ! deoxyribonucleoside biosynthetic process
is_a: GO:0046125 ! pyrimidine deoxyribonucleoside metabolic process
is_a: GO:0046134 ! pyrimidine nucleoside biosynthetic process

[Term]
id: GO:0046127
name: pyrimidine deoxyribonucleoside catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai]
subset: gosubset_prok
synonym: "pyrimidine deoxyribonucleoside breakdown" EXACT []
synonym: "pyrimidine deoxyribonucleoside catabolism" EXACT []
synonym: "pyrimidine deoxyribonucleoside degradation" EXACT []
is_a: GO:0046121 ! deoxyribonucleoside catabolic process
is_a: GO:0046125 ! pyrimidine deoxyribonucleoside metabolic process
is_a: GO:0046135 ! pyrimidine nucleoside catabolic process

[Term]
id: GO:0046128
name: purine ribonucleoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:ai]
subset: gosubset_prok
synonym: "purine ribonucleoside metabolism" EXACT []
is_a: GO:0009119 ! ribonucleoside metabolic process
is_a: GO:0042278 ! purine nucleoside metabolic process

[Term]
id: GO:0046129
name: purine ribonucleoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any purine ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:ai]
subset: gosubset_prok
synonym: "purine ribonucleoside anabolism" EXACT []
synonym: "purine ribonucleoside biosynthesis" EXACT []
synonym: "purine ribonucleoside formation" EXACT []
synonym: "purine ribonucleoside synthesis" EXACT []
is_a: GO:0042451 ! purine nucleoside biosynthetic process
is_a: GO:0042455 ! ribonucleoside biosynthetic process
is_a: GO:0046128 ! purine ribonucleoside metabolic process

[Term]
id: GO:0046130
name: purine ribonucleoside catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any purine ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:ai]
subset: gosubset_prok
synonym: "purine ribonucleoside breakdown" EXACT []
synonym: "purine ribonucleoside catabolism" EXACT []
synonym: "purine ribonucleoside degradation" EXACT []
is_a: GO:0006152 ! purine nucleoside catabolic process
is_a: GO:0042454 ! ribonucleoside catabolic process
is_a: GO:0046128 ! purine ribonucleoside metabolic process

[Term]
id: GO:0046131
name: pyrimidine ribonucleoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:ai]
subset: gosubset_prok
synonym: "pyrimidine ribonucleoside metabolism" EXACT []
is_a: GO:0006213 ! pyrimidine nucleoside metabolic process
is_a: GO:0009119 ! ribonucleoside metabolic process

[Term]
id: GO:0046132
name: pyrimidine ribonucleoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any ribonucleoside, a nucleoside in which a pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:ai]
subset: gosubset_prok
synonym: "pyrimidine ribonucleoside anabolism" EXACT []
synonym: "pyrimidine ribonucleoside biosynthesis" EXACT []
synonym: "pyrimidine ribonucleoside formation" EXACT []
synonym: "pyrimidine ribonucleoside synthesis" EXACT []
is_a: GO:0042455 ! ribonucleoside biosynthetic process
is_a: GO:0046131 ! pyrimidine ribonucleoside metabolic process
is_a: GO:0046134 ! pyrimidine nucleoside biosynthetic process

[Term]
id: GO:0046133
name: pyrimidine ribonucleoside catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any ribonucleoside, a nucleoside in which a pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:ai]
subset: gosubset_prok
synonym: "pyrimidine ribonucleoside breakdown" EXACT []
synonym: "pyrimidine ribonucleoside catabolism" EXACT []
synonym: "pyrimidine ribonucleoside degradation" EXACT []
is_a: GO:0042454 ! ribonucleoside catabolic process
is_a: GO:0046131 ! pyrimidine ribonucleoside metabolic process
is_a: GO:0046135 ! pyrimidine nucleoside catabolic process

[Term]
id: GO:0046134
name: pyrimidine nucleoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:ai]
subset: gosubset_prok
synonym: "pyrimidine nucleoside anabolism" EXACT []
synonym: "pyrimidine nucleoside biosynthesis" EXACT []
synonym: "pyrimidine nucleoside formation" EXACT []
synonym: "pyrimidine nucleoside synthesis" EXACT []
xref: Reactome:REACT_101136 "Pyrimidine biosynthesis, Plasmodium falciparum"
xref: Reactome:REACT_101153 "Pyrimidine biosynthesis, Danio rerio"
xref: Reactome:REACT_105473 "Pyrimidine biosynthesis, Drosophila melanogaster"
xref: Reactome:REACT_108541 "Pyrimidine biosynthesis, Staphylococcus aureus N315"
xref: Reactome:REACT_21376 "Pyrimidine biosynthesis, Homo sapiens"
xref: Reactome:REACT_29226 "Pyrimidine biosynthesis, Sus scrofa"
xref: Reactome:REACT_30611 "Pyrimidine biosynthesis, Dictyostelium discoideum"
xref: Reactome:REACT_78700 "Pyrimidine biosynthesis, Gallus gallus"
xref: Reactome:REACT_79272 "Pyrimidine biosynthesis, Saccharomyces cerevisiae"
xref: Reactome:REACT_79754 "Pyrimidine biosynthesis, Mycobacterium tuberculosis"
xref: Reactome:REACT_79795 "Pyrimidine biosynthesis, Mus musculus"
xref: Reactome:REACT_81447 "Pyrimidine biosynthesis, Xenopus tropicalis"
xref: Reactome:REACT_82063 "Pyrimidine biosynthesis, Oryza sativa"
xref: Reactome:REACT_84581 "Pyrimidine biosynthesis, Escherichia coli"
xref: Reactome:REACT_85629 "Pyrimidine biosynthesis, Canis familiaris"
xref: Reactome:REACT_86260 "Pyrimidine biosynthesis, Caenorhabditis elegans"
xref: Reactome:REACT_87399 "Pyrimidine biosynthesis, Rattus norvegicus"
xref: Reactome:REACT_88432 "Pyrimidine biosynthesis, Schizosaccharomyces pombe"
xref: Reactome:REACT_95322 "Pyrimidine biosynthesis, Taeniopygia guttata"
xref: Reactome:REACT_99305 "Pyrimidine biosynthesis, Bos taurus"
xref: Reactome:REACT_99653 "Pyrimidine biosynthesis, Arabidopsis thaliana"
is_a: GO:0006213 ! pyrimidine nucleoside metabolic process
is_a: GO:0009163 ! nucleoside biosynthetic process
is_a: GO:0072528 ! pyrimidine-containing compound biosynthetic process

[Term]
id: GO:0046135
name: pyrimidine nucleoside catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:ai]
subset: gosubset_prok
synonym: "pyrimidine nucleoside breakdown" EXACT []
synonym: "pyrimidine nucleoside catabolism" EXACT []
synonym: "pyrimidine nucleoside degradation" EXACT []
xref: Reactome:REACT_100711 "Pyrimidine catabolism, Arabidopsis thaliana"
xref: Reactome:REACT_100843 "Pyrimidine catabolism, Mycobacterium tuberculosis"
xref: Reactome:REACT_1023 "Pyrimidine catabolism, Homo sapiens"
xref: Reactome:REACT_107691 "Pyrimidine catabolism, Dictyostelium discoideum"
xref: Reactome:REACT_110762 "Pyrimidine catabolism, Canis familiaris"
xref: Reactome:REACT_113010 "Pyrimidine catabolism, Schizosaccharomyces pombe"
xref: Reactome:REACT_29523 "Pyrimidine catabolism, Sus scrofa"
xref: Reactome:REACT_29587 "Pyrimidine catabolism, Taeniopygia guttata"
xref: Reactome:REACT_32265 "Pyrimidine catabolism, Xenopus tropicalis"
xref: Reactome:REACT_32812 "Pyrimidine catabolism, Caenorhabditis elegans"
xref: Reactome:REACT_33203 "Pyrimidine catabolism, Gallus gallus"
xref: Reactome:REACT_34641 "Pyrimidine catabolism, Danio rerio"
xref: Reactome:REACT_78915 "Pyrimidine catabolism, Bos taurus"
xref: Reactome:REACT_83442 "Pyrimidine catabolism, Oryza sativa"
xref: Reactome:REACT_83454 "Pyrimidine catabolism, Rattus norvegicus"
xref: Reactome:REACT_86439 "Pyrimidine catabolism, Staphylococcus aureus N315"
xref: Reactome:REACT_87746 "Pyrimidine catabolism, Mus musculus"
xref: Reactome:REACT_98226 "Pyrimidine catabolism, Escherichia coli"
xref: Reactome:REACT_99805 "Pyrimidine catabolism, Drosophila melanogaster"
is_a: GO:0006213 ! pyrimidine nucleoside metabolic process
is_a: GO:0009164 ! nucleoside catabolic process
is_a: GO:0072529 ! pyrimidine-containing compound catabolic process

[Term]
id: GO:0046136
name: positive regulation of vitamin metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]
subset: gosubset_prok
synonym: "activation of vitamin metabolic process" NARROW []
synonym: "positive regulation of vitamin metabolism" EXACT []
synonym: "stimulation of vitamin metabolic process" NARROW []
synonym: "up regulation of vitamin metabolic process" EXACT []
synonym: "up-regulation of vitamin metabolic process" EXACT []
synonym: "upregulation of vitamin metabolic process" EXACT []
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0030656 ! regulation of vitamin metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006766 ! vitamin metabolic process
relationship: positively_regulates GO:0006766 ! vitamin metabolic process

[Term]
id: GO:0046137
name: negative regulation of vitamin metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of vitamin metabolic process" EXACT []
synonym: "down-regulation of vitamin metabolic process" EXACT []
synonym: "downregulation of vitamin metabolic process" EXACT []
synonym: "inhibition of vitamin metabolic process" NARROW []
synonym: "negative regulation of vitamin metabolism" EXACT []
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0030656 ! regulation of vitamin metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006766 ! vitamin metabolic process
relationship: negatively_regulates GO:0006766 ! vitamin metabolic process

[Term]
id: GO:0046138
name: obsolete coenzyme and prosthetic group biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of coenzymes and prosthetic groups." [GOC:ai]
comment: This term was made obsolete because it was replaced by more specific terms.
synonym: "coenzyme and prosthetic group anabolism" EXACT []
synonym: "coenzyme and prosthetic group biosynthesis" EXACT []
synonym: "coenzyme and prosthetic group biosynthetic process" EXACT []
synonym: "coenzyme and prosthetic group formation" EXACT []
synonym: "coenzyme and prosthetic group synthesis" EXACT []
is_obsolete: true
consider: GO:0009108
consider: GO:0051191

[Term]
id: GO:0046139
name: obsolete coenzyme and prosthetic group catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of coenzymes and prosthetic groups." [GOC:ai]
comment: This term was made obsolete because it was replaced by more specific terms.
synonym: "coenzyme and prosthetic group breakdown" EXACT []
synonym: "coenzyme and prosthetic group catabolic process" EXACT []
synonym: "coenzyme and prosthetic group catabolism" EXACT []
synonym: "coenzyme and prosthetic group degradation" EXACT []
is_obsolete: true
consider: GO:0009109
consider: GO:0051190

[Term]
id: GO:0046140
name: corrin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of corrin, C19H22N4, the fundamental heterocyclic skeleton of the corrinoids. It consists of four reduced pyrrole rings joined into a macrocyclic ring. Corrin is the core of the vitamin B12 molecule." [GOC:ai]
subset: gosubset_prok
synonym: "corrin anabolism" EXACT []
synonym: "corrin biosynthesis" EXACT []
synonym: "corrin formation" EXACT []
synonym: "corrin synthesis" EXACT []
is_a: GO:0015009 ! corrin metabolic process
is_a: GO:0033014 ! tetrapyrrole biosynthetic process
is_a: GO:0051188 ! cofactor biosynthetic process

[Term]
id: GO:0046141
name: corrin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of corrin, C19H22N4, the fundamental heterocyclic skeleton of the corrinoids. It consists of four reduced pyrrole rings joined into a macrocyclic ring. Corrin is the core of the vitamin B12 molecule." [GOC:ai]
subset: gosubset_prok
synonym: "corrin breakdown" EXACT []
synonym: "corrin catabolism" EXACT []
synonym: "corrin degradation" EXACT []
is_a: GO:0015009 ! corrin metabolic process
is_a: GO:0033015 ! tetrapyrrole catabolic process
is_a: GO:0051187 ! cofactor catabolic process

[Term]
id: GO:0046142
name: obsolete negative regulation of coenzyme and prosthetic group metabolic process
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving coenzymes and prosthetic groups." [GOC:ai]
comment: This term was made obsolete because it was replaced by more specific terms.
synonym: "negative regulation of coenzyme and prosthetic group metabolic process" EXACT []
is_obsolete: true
consider: GO:0051198
consider: GO:0051201

[Term]
id: GO:0046143
name: obsolete positive regulation of coenzyme and prosthetic group metabolic process
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving coenzymes and prosthetic groups." [GOC:ai]
comment: This term was made obsolete because it was replaced by more specific terms.
synonym: "positive regulation of coenzyme and prosthetic group metabolic process" EXACT []
is_obsolete: true
consider: GO:0051197
consider: GO:0051200

[Term]
id: GO:0046144
name: D-alanine family amino acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-alanine and related amino acids." [GOC:ai]
subset: gosubset_prok
synonym: "D-alanine family amino acid metabolism" EXACT []
is_a: GO:0006522 ! alanine metabolic process

[Term]
id: GO:0046145
name: D-alanine family amino acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of D-alanine and related amino acids." [GOC:ai]
subset: gosubset_prok
synonym: "D-alanine family amino acid anabolism" EXACT []
synonym: "D-alanine family amino acid biosynthesis" EXACT []
synonym: "D-alanine family amino acid formation" EXACT []
synonym: "D-alanine family amino acid synthesis" EXACT []
is_a: GO:0006523 ! alanine biosynthetic process
is_a: GO:0046144 ! D-alanine family amino acid metabolic process

[Term]
id: GO:0046146
name: tetrahydrobiopterin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine." [CHEBI:15372, ISBN:0198506732]
subset: gosubset_prok
synonym: "5,6,7,8-tetrahydrobiopterin metabolic process" EXACT [CHEBI:15372, GOC:curators]
synonym: "tetrahydrobiopterin metabolism" EXACT []
is_a: GO:0006732 ! coenzyme metabolic process
is_a: GO:0042558 ! pteridine-containing compound metabolic process

[Term]
id: GO:0046147
name: tetrahydrobiopterin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine." [CHEBI:15372, ISBN:0198506732]
subset: gosubset_prok
synonym: "5,6,7,8-tetrahydrobiopterin catabolic process" EXACT [CHEBI:15372, GOC:curators]
synonym: "tetrahydrobiopterin breakdown" EXACT []
synonym: "tetrahydrobiopterin catabolism" EXACT []
synonym: "tetrahydrobiopterin degradation" EXACT []
is_a: GO:0009109 ! coenzyme catabolic process
is_a: GO:0042560 ! pteridine-containing compound catabolic process
is_a: GO:0046146 ! tetrahydrobiopterin metabolic process

[Term]
id: GO:0046148
name: pigment biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [ISBN:0198506732]
subset: gosubset_prok
synonym: "pigment anabolism" EXACT []
synonym: "pigment biosynthesis" EXACT []
synonym: "pigment formation" EXACT []
synonym: "pigment synthesis" EXACT []
is_a: GO:0042440 ! pigment metabolic process
is_a: GO:0044711 ! single-organism biosynthetic process

[Term]
id: GO:0046149
name: pigment catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [ISBN:0198506732]
subset: gosubset_prok
synonym: "pigment breakdown" EXACT []
synonym: "pigment catabolism" EXACT []
synonym: "pigment degradation" EXACT []
is_a: GO:0042440 ! pigment metabolic process
is_a: GO:0044712 ! single-organism catabolic process

[Term]
id: GO:0046150
name: melanin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom." [ISBN:0198506732]
subset: gosubset_prok
synonym: "melanin breakdown" EXACT []
synonym: "melanin catabolism" EXACT []
synonym: "melanin degradation" EXACT []
is_a: GO:0006582 ! melanin metabolic process
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0046149 ! pigment catabolic process

[Term]
id: GO:0046151
name: eye pigment catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye." [GOC:ai]
synonym: "eye pigment breakdown" EXACT []
synonym: "eye pigment catabolism" EXACT []
synonym: "eye pigment degradation" EXACT []
is_a: GO:0042441 ! eye pigment metabolic process
is_a: GO:0046149 ! pigment catabolic process

[Term]
id: GO:0046152
name: ommochrome metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye." [ISBN:0198506732]
synonym: "ommochrome metabolism" EXACT []
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0042441 ! eye pigment metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0046158 ! ocellus pigment metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process

[Term]
id: GO:0046153
name: ommochrome catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye." [ISBN:0198506732]
synonym: "ommochrome breakdown" EXACT []
synonym: "ommochrome catabolism" EXACT []
synonym: "ommochrome degradation" EXACT []
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0046151 ! eye pigment catabolic process
is_a: GO:0046152 ! ommochrome metabolic process
is_a: GO:0046159 ! ocellus pigment catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process

[Term]
id: GO:0046154
name: rhodopsin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas." [ISBN:0198506732]
synonym: "rhodopsin metabolism" EXACT []
is_a: GO:0042441 ! eye pigment metabolic process
is_a: GO:0044267 ! cellular protein metabolic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0046155
name: rhodopsin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas." [ISBN:0198506732]
synonym: "rhodopsin breakdown" EXACT []
synonym: "rhodopsin catabolism" EXACT []
synonym: "rhodopsin degradation" EXACT []
is_a: GO:0044257 ! cellular protein catabolic process
is_a: GO:0046151 ! eye pigment catabolic process
is_a: GO:0046154 ! rhodopsin metabolic process

[Term]
id: GO:0046156
name: siroheme metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving siroheme, a tetrahydroporphyrin with adjacent, reduced pyrrole rings." [ISBN:0198506732]
subset: gosubset_prok
synonym: "sirohaem metabolic process" EXACT []
synonym: "sirohaem metabolism" EXACT []
synonym: "siroheme metabolism" EXACT []
is_a: GO:0042168 ! heme metabolic process

[Term]
id: GO:0046157
name: siroheme catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of siroheme, a tetrahydroporphyrin with adjacent, reduced pyrrole rings." [ISBN:0198506732]
subset: gosubset_prok
synonym: "sirohaem catabolic process" EXACT []
synonym: "sirohaem catabolism" EXACT []
synonym: "siroheme breakdown" EXACT []
synonym: "siroheme catabolism" EXACT []
synonym: "siroheme degradation" EXACT []
is_a: GO:0042167 ! heme catabolic process
is_a: GO:0046156 ! siroheme metabolic process

[Term]
id: GO:0046158
name: ocellus pigment metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ocellus pigments, any general or particular coloring matter in living organisms, found or utilized in the ocellus, a minute simple eye found in many invertebrates." [GOC:ai, PMID:15176085, PMID:18421706]
synonym: "ocellus pigment metabolism" EXACT []
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0043474 ! pigment metabolic process involved in pigmentation
relationship: part_of GO:0033060 ! ocellus pigmentation

[Term]
id: GO:0046159
name: ocellus pigment catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ocellus pigments, any general or particular coloring matter in living organisms, found or utilized in the ocellus, a minute simple eye found in many invertebrates." [GOC:ai, PMID:15176085, PMID:18421706]
synonym: "ocellus pigment breakdown" EXACT []
synonym: "ocellus pigment catabolism" EXACT []
synonym: "ocellus pigment degradation" EXACT []
is_a: GO:0046149 ! pigment catabolic process
is_a: GO:0046158 ! ocellus pigment metabolic process

[Term]
id: GO:0046160
name: heme a metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving heme a, a derivative of heme found in cytochrome aa3." [CHEBI:24479, GOC:curators]
subset: gosubset_prok
synonym: "haem a metabolic process" EXACT []
synonym: "haem a metabolism" EXACT []
synonym: "heme a metabolism" EXACT []
is_a: GO:0042168 ! heme metabolic process

[Term]
id: GO:0046161
name: heme a catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of heme a, a derivative of heme found in cytochrome aa3." [CHEBI:24479, GOC:curators]
subset: gosubset_prok
synonym: "haem a catabolic process" EXACT []
synonym: "haem a catabolism" EXACT []
synonym: "heme a breakdown" EXACT []
synonym: "heme a catabolism" EXACT []
synonym: "heme a degradation" EXACT []
is_a: GO:0042167 ! heme catabolic process
is_a: GO:0046160 ! heme a metabolic process

[Term]
id: GO:0046162
name: heme c metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving heme c, a derivative of heme found in cytochromes c, b4, and f." [GOC:curators, PubChem_Compound:122208]
subset: gosubset_prok
synonym: "haem c metabolic process" EXACT []
synonym: "haem c metabolism" EXACT []
synonym: "heme c metabolism" EXACT []
is_a: GO:0042168 ! heme metabolic process

[Term]
id: GO:0046163
name: heme c catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of heme c, a derivative of heme found in cytochromes c, b4, and f." [GOC:curators, PubChem_Compound:122208]
subset: gosubset_prok
synonym: "haem c catabolic process" EXACT []
synonym: "haem c catabolism" EXACT []
synonym: "heme c breakdown" EXACT []
synonym: "heme c catabolism" EXACT []
synonym: "heme c degradation" EXACT []
is_a: GO:0042167 ! heme catabolic process
is_a: GO:0046162 ! heme c metabolic process

[Term]
id: GO:0046164
name: alcohol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, GOC:ai]
subset: gosubset_prok
synonym: "alcohol breakdown" EXACT []
synonym: "alcohol catabolism" EXACT []
synonym: "alcohol degradation" EXACT []
is_a: GO:0006066 ! alcohol metabolic process
is_a: GO:0044282 ! small molecule catabolic process
is_a: GO:1901616 ! organic hydroxy compound catabolic process

[Term]
id: GO:0046165
name: alcohol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, GOC:ai]
subset: gosubset_prok
synonym: "alcohol anabolism" EXACT []
synonym: "alcohol biosynthesis" EXACT []
synonym: "alcohol formation" EXACT []
synonym: "alcohol synthesis" EXACT []
is_a: GO:0006066 ! alcohol metabolic process
is_a: GO:0044283 ! small molecule biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process

[Term]
id: GO:0046166
name: glyceraldehyde-3-phosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glyceraldehyde-3-phosphate, an important intermediate in glycolysis." [GOC:ai]
subset: gosubset_prok
synonym: "glyceraldehyde 3-phosphate biosynthesis" EXACT []
synonym: "glyceraldehyde 3-phosphate biosynthetic process" EXACT []
synonym: "glyceraldehyde-3-phosphate anabolism" EXACT []
synonym: "glyceraldehyde-3-phosphate biosynthesis" EXACT []
synonym: "glyceraldehyde-3-phosphate formation" EXACT []
synonym: "glyceraldehyde-3-phosphate synthesis" EXACT []
is_a: GO:0019682 ! glyceraldehyde-3-phosphate metabolic process
is_a: GO:0046184 ! aldehyde biosynthetic process
is_a: GO:0090407 ! organophosphate biosynthetic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process

[Term]
id: GO:0046167
name: glycerol-3-phosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:ai]
subset: gosubset_prok
synonym: "glycerol-3-phosphate anabolism" EXACT []
synonym: "glycerol-3-phosphate biosynthesis" EXACT []
synonym: "glycerol-3-phosphate formation" EXACT []
synonym: "glycerol-3-phosphate synthesis" EXACT []
is_a: GO:0006072 ! glycerol-3-phosphate metabolic process
is_a: GO:0090407 ! organophosphate biosynthetic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process

[Term]
id: GO:0046168
name: glycerol-3-phosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:ai]
subset: gosubset_prok
synonym: "glycerol-3-phosphate breakdown" EXACT []
synonym: "glycerol-3-phosphate catabolism" EXACT []
synonym: "glycerol-3-phosphate degradation" EXACT []
is_a: GO:0006072 ! glycerol-3-phosphate metabolic process
is_a: GO:0046434 ! organophosphate catabolic process
is_a: GO:1901136 ! carbohydrate derivative catabolic process

[Term]
id: GO:0046169
name: methanol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of methanol, CH3-OH, a colorless, flammable, mobile, poisonous liquid, widely used as a solvent." [GOC:ai]
subset: gosubset_prok
synonym: "methanol anabolism" EXACT []
synonym: "methanol biosynthesis" EXACT []
synonym: "methanol formation" EXACT []
synonym: "methanol synthesis" EXACT []
is_a: GO:0015945 ! methanol metabolic process
is_a: GO:0034309 ! primary alcohol biosynthetic process

[Term]
id: GO:0046170
name: methanol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of methanol, CH3-OH, a colorless, flammable, mobile, poisonous liquid, widely used as a solvent." [GOC:ai]
subset: gosubset_prok
synonym: "methanol breakdown" EXACT []
synonym: "methanol catabolism" EXACT []
synonym: "methanol degradation" EXACT []
is_a: GO:0015945 ! methanol metabolic process
is_a: GO:0034310 ! primary alcohol catabolic process

[Term]
id: GO:0046171
name: octanol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of octanol, the 8-carbon alcohol with the formula C8H17OH." [GOC:ai]
subset: gosubset_prok
synonym: "octanol anabolism" EXACT []
synonym: "octanol biosynthesis" EXACT []
synonym: "octanol formation" EXACT []
synonym: "octanol synthesis" EXACT []
is_a: GO:0006070 ! octanol metabolic process
is_a: GO:0034309 ! primary alcohol biosynthetic process
is_a: GO:1903175 ! fatty alcohol biosynthetic process

[Term]
id: GO:0046172
name: octanol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of octanol, the 8-carbon alcohol with the formula C8H17OH." [GOC:ai]
subset: gosubset_prok
synonym: "octanol breakdown" EXACT []
synonym: "octanol catabolism" EXACT []
synonym: "octanol degradation" EXACT []
is_a: GO:0006070 ! octanol metabolic process
is_a: GO:0034310 ! primary alcohol catabolic process
is_a: GO:1903174 ! fatty alcohol catabolic process

[Term]
id: GO:0046173
name: polyol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms." [CHEBI:26191]
subset: gosubset_prok
synonym: "polyhydric alcohol biosynthetic process" EXACT []
synonym: "polyol anabolism" EXACT []
synonym: "polyol biosynthesis" EXACT []
synonym: "polyol formation" EXACT []
synonym: "polyol synthesis" EXACT []
is_a: GO:0019751 ! polyol metabolic process
is_a: GO:0046165 ! alcohol biosynthetic process

[Term]
id: GO:0046174
name: polyol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms." [CHEBI:26191]
subset: gosubset_prok
synonym: "polyhydric alcohol catabolic process" EXACT []
synonym: "polyol breakdown" EXACT []
synonym: "polyol catabolism" EXACT []
synonym: "polyol degradation" EXACT []
is_a: GO:0019751 ! polyol metabolic process
is_a: GO:0046164 ! alcohol catabolic process

[Term]
id: GO:0046175
name: aldonic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of aldonic acid, a monocarboxylic acid with a chain of three or more carbon atoms, derived from an aldose by oxidation of the aldehydic group." [ISBN:0198506732]
subset: gosubset_prok
synonym: "aldonic acid anabolism" EXACT []
synonym: "aldonic acid biosynthesis" EXACT []
synonym: "aldonic acid formation" EXACT []
synonym: "aldonic acid synthesis" EXACT []
is_a: GO:0019520 ! aldonic acid metabolic process
is_a: GO:0034637 ! cellular carbohydrate biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process

[Term]
id: GO:0046176
name: aldonic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of aldonic acid, a monocarboxylic acid with a chain of three or more carbon atoms, derived from an aldose by oxidation of the aldehydic group." [ISBN:0198506732]
subset: gosubset_prok
synonym: "aldonic acid breakdown" EXACT []
synonym: "aldonic acid catabolism" EXACT []
synonym: "aldonic acid degradation" EXACT []
is_a: GO:0019520 ! aldonic acid metabolic process
is_a: GO:0044275 ! cellular carbohydrate catabolic process
is_a: GO:0044724 ! single-organism carbohydrate catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0046177
name: D-gluconate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-gluconate, the anion of D-gluconic acid, the aldonic acid derived from glucose." [ISBN:0198506732]
subset: gosubset_prok
synonym: "D-gluconate breakdown" EXACT []
synonym: "D-gluconate catabolism" EXACT []
synonym: "D-gluconate degradation" EXACT []
xref: MetaCyc:GLUCONSUPER-PWY
is_a: GO:0019521 ! D-gluconate metabolic process
is_a: GO:0046176 ! aldonic acid catabolic process

[Term]
id: GO:0046178
name: D-gluconate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of D-gluconate, the anion of D-gluconic acid, the aldonic acid derived from glucose." [ISBN:0198506732]
subset: gosubset_prok
synonym: "D-gluconate anabolism" EXACT []
synonym: "D-gluconate biosynthesis" EXACT []
synonym: "D-gluconate formation" EXACT []
synonym: "D-gluconate synthesis" EXACT []
is_a: GO:0019521 ! D-gluconate metabolic process
is_a: GO:0046175 ! aldonic acid biosynthetic process

[Term]
id: GO:0046179
name: keto-D-gluconate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of keto-D-gluconate, the anion of keto-D-gluconic acid, an aldonic acid derived from glucose." [ISBN:0198506732]
subset: gosubset_prok
synonym: "keto-D-gluconate anabolism" EXACT []
synonym: "keto-D-gluconate biosynthesis" EXACT []
synonym: "keto-D-gluconate formation" EXACT []
synonym: "keto-D-gluconate synthesis" EXACT []
is_a: GO:0019525 ! keto-D-gluconate metabolic process
is_a: GO:0046180 ! ketogluconate biosynthetic process

[Term]
id: GO:0046180
name: ketogluconate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ketogluconate, the anion of ketogluconic acid, an aldonic acid derived from glucose containing a ketonic carbonyl group." [ISBN:0198506732]
subset: gosubset_prok
synonym: "ketogluconate anabolism" EXACT []
synonym: "ketogluconate biosynthesis" EXACT []
synonym: "ketogluconate formation" EXACT []
synonym: "ketogluconate synthesis" EXACT []
is_a: GO:0019522 ! ketogluconate metabolic process
is_a: GO:0046175 ! aldonic acid biosynthetic process

[Term]
id: GO:0046181
name: ketogluconate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ketogluconate, the anion of ketogluconic acid, an aldonic acid derived from glucose containing a ketonic carbonyl group." [ISBN:0198506732]
subset: gosubset_prok
synonym: "ketogluconate breakdown" EXACT []
synonym: "ketogluconate catabolism" EXACT []
synonym: "ketogluconate degradation" EXACT []
is_a: GO:0019522 ! ketogluconate metabolic process
is_a: GO:0046176 ! aldonic acid catabolic process

[Term]
id: GO:0046182
name: L-idonate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-idonate, the anion of idonic acid, an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose." [CHEBI:17796, GOC:curators]
subset: gosubset_prok
synonym: "L-idonate anabolism" EXACT []
synonym: "L-idonate biosynthesis" EXACT []
synonym: "L-idonate formation" EXACT []
synonym: "L-idonate synthesis" EXACT []
is_a: GO:0019523 ! L-idonate metabolic process
is_a: GO:0046175 ! aldonic acid biosynthetic process

[Term]
id: GO:0046183
name: L-idonate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-idonate, the anion of idonic acid, an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose." [CHEBI:17796, GOC:curators]
subset: gosubset_prok
synonym: "L-idonate breakdown" EXACT []
synonym: "L-idonate catabolism" EXACT []
synonym: "L-idonate degradation" EXACT []
is_a: GO:0019523 ! L-idonate metabolic process
is_a: GO:0046176 ! aldonic acid catabolic process

[Term]
id: GO:0046184
name: aldehyde biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of aldehydes, any organic compound with the formula R-CH=O." [GOC:ai]
subset: gosubset_prok
synonym: "aldehyde anabolism" EXACT []
synonym: "aldehyde biosynthesis" EXACT []
synonym: "aldehyde formation" EXACT []
synonym: "aldehyde synthesis" EXACT []
is_a: GO:0006081 ! cellular aldehyde metabolic process
is_a: GO:0044249 ! cellular biosynthetic process
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:1901576 ! organic substance biosynthetic process

[Term]
id: GO:0046185
name: aldehyde catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of aldehydes, any organic compound with the formula R-CH=O." [GOC:ai]
subset: gosubset_prok
synonym: "aldehyde breakdown" EXACT []
synonym: "aldehyde catabolism" EXACT []
synonym: "aldehyde degradation" EXACT []
is_a: GO:0006081 ! cellular aldehyde metabolic process
is_a: GO:0044248 ! cellular catabolic process
is_a: GO:0044712 ! single-organism catabolic process
is_a: GO:1901575 ! organic substance catabolic process

[Term]
id: GO:0046186
name: acetaldehyde biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of acetaldehyde, a colorless, flammable liquid intermediate in the metabolism of alcohol." [GOC:ai]
subset: gosubset_prok
synonym: "acetaldehyde anabolism" EXACT []
synonym: "acetaldehyde biosynthesis" EXACT []
synonym: "acetaldehyde formation" EXACT []
synonym: "acetaldehyde synthesis" EXACT []
is_a: GO:0006117 ! acetaldehyde metabolic process
is_a: GO:0046184 ! aldehyde biosynthetic process

[Term]
id: GO:0046187
name: acetaldehyde catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of acetaldehyde, a colorless, flammable liquid intermediate in the metabolism of alcohol." [GOC:ai]
subset: gosubset_prok
synonym: "acetaldehyde breakdown" EXACT []
synonym: "acetaldehyde catabolism" EXACT []
synonym: "acetaldehyde degradation" EXACT []
is_a: GO:0006117 ! acetaldehyde metabolic process
is_a: GO:0046185 ! aldehyde catabolic process

[Term]
id: GO:0046188
name: methane catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of methane, a colorless, odorless, flammable gas with the formula CH4. It is the simplest of the alkanes." [GOC:ai]
subset: gosubset_prok
synonym: "methane breakdown" EXACT []
synonym: "methane catabolism" EXACT []
synonym: "methane degradation" EXACT []
is_a: GO:0015947 ! methane metabolic process
is_a: GO:0043448 ! alkane catabolic process

[Term]
id: GO:0046189
name: phenol-containing compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring." [CHEBI:33853, GOC:ai]
subset: gosubset_prok
synonym: "phenol-containing compound anabolism" EXACT [GOC:curators]
synonym: "phenol-containing compound biosynthesis" EXACT [GOC:curators]
synonym: "phenol-containing compound formation" EXACT [GOC:curators]
synonym: "phenol-containing compound synthesis" EXACT [GOC:curators]
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process

[Term]
id: GO:0046190
name: aerobic phenol-containing compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the presence of oxygen." [CHEBI:33853, GOC:ai]
subset: gosubset_prok
synonym: "aerobic phenol-containing compound anabolism" EXACT [GOC:curators]
synonym: "aerobic phenol-containing compound biosynthesis" EXACT [GOC:curators]
synonym: "aerobic phenol-containing compound formation" EXACT [GOC:curators]
synonym: "aerobic phenol-containing compound synthesis" EXACT [GOC:curators]
is_a: GO:0018959 ! aerobic phenol-containing compound metabolic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process

[Term]
id: GO:0046191
name: aerobic phenol-containing compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the presence of oxygen." [CHEBI:33853, GOC:ai]
subset: gosubset_prok
synonym: "aerobic phenol-containing compound breakdown" EXACT [GOC:curators]
synonym: "aerobic phenol-containing compound catabolism" EXACT [GOC:curators]
synonym: "aerobic phenol-containing compound degradation" EXACT [GOC:curators]
is_a: GO:0018959 ! aerobic phenol-containing compound metabolic process
is_a: GO:0019336 ! phenol-containing compound catabolic process

[Term]
id: GO:0046192
name: anaerobic phenol-containing compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the absence of oxygen." [CHEBI:33853, GOC:ai]
subset: gosubset_prok
synonym: "anaerobic phenol-containing compound anabolism" EXACT [GOC:curators]
synonym: "anaerobic phenol-containing compound biosynthesis" EXACT [GOC:curators]
synonym: "anaerobic phenol-containing compound formation" EXACT [GOC:curators]
synonym: "anaerobic phenol-containing compound synthesis" EXACT [GOC:curators]
is_a: GO:0042215 ! anaerobic phenol-containing compound metabolic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process

[Term]
id: GO:0046193
name: anaerobic phenol-containing compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the absence of oxygen." [CHEBI:33853, GOC:ai]
subset: gosubset_prok
synonym: "anaerobic phenol-containing compound breakdown" EXACT [GOC:curators]
synonym: "anaerobic phenol-containing compound catabolism" EXACT [GOC:curators]
synonym: "anaerobic phenol-containing compound degradation" EXACT [GOC:curators]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0042215 ! anaerobic phenol-containing compound metabolic process

[Term]
id: GO:0046194
name: obsolete pentachlorophenol biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of pentachlorophenol, a chlorinated insecticide and fungicide used primarily to protect timber from fungal rot and wood boring insects. Pentachlorophenol is significantly toxic to mammals, plants, and many microorganisms." [GOC:ai]
comment: This term was made obsolete because pentachlorophenol is not synthesized by living organisms and GO does not cover non-biological processes.
synonym: "pentachlorophenol anabolism" EXACT []
synonym: "pentachlorophenol biosynthesis" EXACT []
synonym: "pentachlorophenol biosynthetic process" EXACT []
synonym: "pentachlorophenol formation" EXACT []
synonym: "pentachlorophenol synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018961

[Term]
id: GO:0046195
name: obsolete 4-nitrophenol biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 4-nitrophenol, a nitroaromatic compound which is used in the production of dyes, leather treatment agents, fungicides and as an intermediate in the production of the insecticide parathion." [GOC:ai]
comment: This term was made obsolete because 4-nitrophenol is not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "4-nitrophenol anabolism" EXACT []
synonym: "4-nitrophenol biosynthesis" EXACT []
synonym: "4-nitrophenol biosynthetic process" EXACT []
synonym: "4-nitrophenol formation" EXACT []
synonym: "4-nitrophenol synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018960

[Term]
id: GO:0046196
name: 4-nitrophenol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 4-nitrophenol, a nitroaromatic compound which is used in the production of dyes, leather treatment agents, fungicides and as an intermediate in the production of the insecticide parathion." [GOC:ai]
subset: gosubset_prok
synonym: "4-nitrophenol breakdown" EXACT []
synonym: "4-nitrophenol catabolism" EXACT []
synonym: "4-nitrophenol degradation" EXACT []
is_a: GO:0018960 ! 4-nitrophenol metabolic process
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0042178 ! xenobiotic catabolic process

[Term]
id: GO:0046197
name: orcinol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of orcinol (5-methyl-1,3-benzenediol), an aromatic compound derived from the fermentation of lichen and synthesized by some higher plants." [GOC:ai]
subset: gosubset_prok
synonym: "orcinol anabolism" EXACT []
synonym: "orcinol biosynthesis" EXACT []
synonym: "orcinol formation" EXACT []
synonym: "orcinol synthesis" EXACT []
is_a: GO:0018940 ! orcinol metabolic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process

[Term]
id: GO:0046198
name: obsolete cresol biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of cresol, a mixture of the aromatic alcohol isoforms o-, p-, and m-cresol, which is obtained from coal tar or petroleum. The isomers are used as disinfectants, textile scouring agents, surfactants and as intermediates in the manufacture of salicylaldehyde, coumarin, and herbicides as well as being a major component of creosote." [GOC:ai]
comment: This term was made obsolete because cresol is not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "cresol anabolism" EXACT []
synonym: "cresol biosynthesis" EXACT []
synonym: "cresol biosynthetic process" EXACT []
synonym: "cresol formation" EXACT []
synonym: "cresol synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0042212

[Term]
id: GO:0046199
name: cresol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cresol, a mixture of the aromatic alcohol isoforms o-, p-, and m-cresol, which is obtained from coal tar or petroleum. The isomers are used as disinfectants, textile scouring agents, surfactants and as intermediates in the manufacture of salicylaldehyde, coumarin, and herbicides as well as being a major component of creosote." [GOC:ai]
subset: gosubset_prok
synonym: "cresol breakdown" EXACT []
synonym: "cresol catabolism" EXACT []
synonym: "cresol degradation" EXACT []
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0042212 ! cresol metabolic process
is_a: GO:0072491 ! toluene-containing compound catabolic process

[Term]
id: GO:0046200
name: obsolete m-cresol biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of m-cresol (3-hydroxytoluene), the meta-isoform of cresol." [GOC:ai]
comment: This term was made obsolete because m-cresol is not synthesized by living organisms and GO does not cover non-biological processes.
synonym: "m-cresol anabolism" EXACT []
synonym: "m-cresol biosynthesis" EXACT []
synonym: "m-cresol biosynthetic process" EXACT []
synonym: "m-cresol formation" EXACT []
synonym: "m-cresol synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018925

[Term]
id: GO:0046201
name: cyanate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cyanate, NCO-, the anion of cyanic acid." [GOC:ai]
subset: gosubset_prok
synonym: "cyanate anabolism" EXACT []
synonym: "cyanate biosynthesis" EXACT []
synonym: "cyanate formation" EXACT []
synonym: "cyanate synthesis" EXACT []
is_a: GO:0009439 ! cyanate metabolic process
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process

[Term]
id: GO:0046202
name: cyanide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cyanide, NC-, the anion of hydrocyanic acid. Cyanide is a potent inhibitor of respiration." [GOC:ai]
subset: gosubset_prok
synonym: "cyanide anabolism" EXACT []
synonym: "cyanide biosynthesis" EXACT []
synonym: "cyanide formation" EXACT []
synonym: "cyanide synthesis" EXACT []
is_a: GO:0019499 ! cyanide metabolic process
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:1901576 ! organic substance biosynthetic process

[Term]
id: GO:0046203
name: spermidine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:ai]
subset: gosubset_prok
synonym: "spermidine breakdown" EXACT []
synonym: "spermidine catabolism" EXACT []
synonym: "spermidine degradation" EXACT []
is_a: GO:0006598 ! polyamine catabolic process
is_a: GO:0008216 ! spermidine metabolic process

[Term]
id: GO:0046204
name: nor-spermidine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nor-spermidine, a compound related to spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:ai]
subset: gosubset_prok
synonym: "nor-spermidine metabolism" EXACT []
is_a: GO:0006595 ! polyamine metabolic process
is_a: GO:0097164 ! ammonium ion metabolic process

[Term]
id: GO:0046205
name: nor-spermidine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of nor-spermidine, a compound related to spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:ai]
subset: gosubset_prok
synonym: "nor-spermidine breakdown" EXACT []
synonym: "nor-spermidine catabolism" EXACT []
synonym: "nor-spermidine degradation" EXACT []
is_a: GO:0006598 ! polyamine catabolic process
is_a: GO:0046204 ! nor-spermidine metabolic process

[Term]
id: GO:0046206
name: trypanothione metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving trypanothione (N1,N6,-bis(glutathionyl)spermidine), an essential redox intermediate in intracellular thiol redox regulation which also plays a role in protecting against oxidative stress." [GOC:ai]
subset: gosubset_prok
synonym: "trypanothione metabolism" EXACT []
is_a: GO:1901685 ! glutathione derivative metabolic process

[Term]
id: GO:0046207
name: trypanothione catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of trypanothione (N1,N6,-bis(glutathionyl)spermidine), an essential redox intermediate in intracellular thiol redox regulation which also plays a role in protecting against oxidative stress." [GOC:ai]
subset: gosubset_prok
synonym: "trypanothione breakdown" EXACT []
synonym: "trypanothione catabolism" EXACT []
synonym: "trypanothione degradation" EXACT []
is_a: GO:0046206 ! trypanothione metabolic process
is_a: GO:1901686 ! glutathione derivative catabolic process

[Term]
id: GO:0046208
name: spermine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses and involved in nucleic acid packaging." [CHEBI:15746, GOC:curators]
subset: gosubset_prok
synonym: "spermine breakdown" EXACT []
synonym: "spermine catabolism" EXACT []
synonym: "spermine degradation" EXACT []
is_a: GO:0006598 ! polyamine catabolic process
is_a: GO:0008215 ! spermine metabolic process

[Term]
id: GO:0046209
name: nitric oxide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water." [GOC:ai]
subset: gosubset_prok
synonym: "nitric oxide metabolism" EXACT []
xref: Reactome:REACT_105812 "Metabolism of nitric oxide, Danio rerio"
xref: Reactome:REACT_114905 "Metabolism of nitric oxide, Taeniopygia guttata"
xref: Reactome:REACT_12508 "Metabolism of nitric oxide, Homo sapiens"
xref: Reactome:REACT_32922 "Metabolism of nitric oxide, Sus scrofa"
xref: Reactome:REACT_34204 "Metabolism of nitric oxide, Xenopus tropicalis"
xref: Reactome:REACT_77746 "Metabolism of nitric oxide, Rattus norvegicus"
xref: Reactome:REACT_84564 "Metabolism of nitric oxide, Canis familiaris"
xref: Reactome:REACT_89877 "Metabolism of nitric oxide, Bos taurus"
xref: Reactome:REACT_95483 "Metabolism of nitric oxide, Mus musculus"
is_a: GO:0072593 ! reactive oxygen species metabolic process
is_a: GO:2001057 ! reactive nitrogen species metabolic process

[Term]
id: GO:0046210
name: nitric oxide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water." [GOC:ai]
subset: gosubset_prok
synonym: "nitric oxide breakdown" EXACT []
synonym: "nitric oxide catabolism" EXACT []
synonym: "nitric oxide degradation" EXACT []
is_a: GO:0044270 ! cellular nitrogen compound catabolic process
is_a: GO:0046209 ! nitric oxide metabolic process

[Term]
id: GO:0046211
name: (+)-camphor biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (+)-camphor, a bicyclic monoterpene ketone." [GOC:ai]
subset: gosubset_prok
synonym: "(+)-camphor anabolism" EXACT []
synonym: "(+)-camphor biosynthesis" EXACT []
synonym: "(+)-camphor formation" EXACT []
synonym: "(+)-camphor synthesis" EXACT []
is_a: GO:0016099 ! monoterpenoid biosynthetic process
is_a: GO:0018882 ! (+)-camphor metabolic process
is_a: GO:0042181 ! ketone biosynthetic process

[Term]
id: GO:0046212
name: obsolete methyl ethyl ketone biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of methyl ethyl ketone, a clear, colorless liquid with a fragrant, mint-like odor. It is used as a solvent and in making plastics, textiles and paints." [GOC:ai]
comment: This term was made obsolete because methyl ethyl ketone is not synthesized by living organisms and GO does not cover non-biological processes.
synonym: "methyl ethyl ketone anabolism" EXACT []
synonym: "methyl ethyl ketone biosynthesis" EXACT []
synonym: "methyl ethyl ketone biosynthetic process" EXACT []
synonym: "methyl ethyl ketone formation" EXACT []
synonym: "methyl ethyl ketone synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018928

[Term]
id: GO:0046213
name: methyl ethyl ketone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of methyl ethyl ketone, a clear, colorless liquid with a fragrant, mint-like odor." [GOC:ai]
subset: gosubset_prok
synonym: "methyl ethyl ketone breakdown" EXACT []
synonym: "methyl ethyl ketone catabolism" EXACT []
synonym: "methyl ethyl ketone degradation" EXACT []
is_a: GO:0018928 ! methyl ethyl ketone metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0042182 ! ketone catabolic process

[Term]
id: GO:0046214
name: enterobactin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway." [GOC:ai]
subset: gosubset_prok
synonym: "enterobactin breakdown" EXACT []
synonym: "enterobactin catabolism" EXACT []
synonym: "enterobactin degradation" EXACT []
is_a: GO:0009238 ! enterobactin metabolic process
is_a: GO:0019614 ! catechol-containing compound catabolic process
is_a: GO:0046215 ! siderophore catabolic process
is_a: GO:0046700 ! heterocycle catabolic process

[Term]
id: GO:0046215
name: siderophore catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action." [GOC:ai]
subset: gosubset_prok
synonym: "siderochrome catabolism" NARROW []
synonym: "siderophore breakdown" EXACT []
synonym: "siderophore catabolism" EXACT []
synonym: "siderophore degradation" EXACT []
is_a: GO:0009237 ! siderophore metabolic process
is_a: GO:0051187 ! cofactor catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process

[Term]
id: GO:0046216
name: indole phytoalexin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of indole phytoalexins, any indole compound produced by plants as part of their defense response." [GOC:ai]
subset: gosubset_prok
synonym: "indole phytoalexin breakdown" EXACT []
synonym: "indole phytoalexin catabolism" EXACT []
synonym: "indole phytoalexin degradation" EXACT []
is_a: GO:0042436 ! indole-containing compound catabolic process
is_a: GO:0046217 ! indole phytoalexin metabolic process
is_a: GO:0052316 ! phytoalexin catabolic process

[Term]
id: GO:0046217
name: indole phytoalexin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving indole phytoalexins, any indole compound produced by plants as part of their defense response." [GOC:ai]
subset: gosubset_prok
synonym: "indole phytoalexin metabolism" EXACT []
is_a: GO:0042430 ! indole-containing compound metabolic process
is_a: GO:0052314 ! phytoalexin metabolic process

[Term]
id: GO:0046218
name: indolalkylamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group." [CHEBI:38631, GOC:curators]
subset: gosubset_prok
synonym: "indolalkylamine breakdown" EXACT []
synonym: "indolalkylamine catabolism" EXACT []
synonym: "indolalkylamine degradation" EXACT []
is_a: GO:0006586 ! indolalkylamine metabolic process
is_a: GO:0042402 ! cellular biogenic amine catabolic process
is_a: GO:0042436 ! indole-containing compound catabolic process

[Term]
id: GO:0046219
name: indolalkylamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group." [CHEBI:38631, GOC:curators]
subset: gosubset_prok
synonym: "indolalkylamine anabolism" EXACT []
synonym: "indolalkylamine biosynthesis" EXACT []
synonym: "indolalkylamine formation" EXACT []
synonym: "indolalkylamine synthesis" EXACT []
xref: Reactome:REACT_101164 "Serotonin and melatonin biosynthesis, Mus musculus"
xref: Reactome:REACT_103672 "Serotonin and melatonin biosynthesis, Taeniopygia guttata"
xref: Reactome:REACT_15439 "Serotonin and melatonin biosynthesis, Homo sapiens"
xref: Reactome:REACT_30358 "Serotonin and melatonin biosynthesis, Drosophila melanogaster"
xref: Reactome:REACT_33335 "Serotonin and melatonin biosynthesis, Gallus gallus"
xref: Reactome:REACT_77232 "Serotonin and melatonin biosynthesis, Mycobacterium tuberculosis"
xref: Reactome:REACT_78688 "Serotonin and melatonin biosynthesis, Dictyostelium discoideum"
xref: Reactome:REACT_80164 "Serotonin and melatonin biosynthesis, Xenopus tropicalis"
xref: Reactome:REACT_81826 "Serotonin and melatonin biosynthesis, Oryza sativa"
xref: Reactome:REACT_85355 "Serotonin and melatonin biosynthesis, Arabidopsis thaliana"
xref: Reactome:REACT_89841 "Serotonin and melatonin biosynthesis, Canis familiaris"
xref: Reactome:REACT_93100 "Serotonin and melatonin biosynthesis, Danio rerio"
xref: Reactome:REACT_93446 "Serotonin and melatonin biosynthesis, Bos taurus"
xref: Reactome:REACT_93673 "Serotonin and melatonin biosynthesis, Sus scrofa"
xref: Reactome:REACT_94712 "Serotonin and melatonin biosynthesis, Caenorhabditis elegans"
xref: Reactome:REACT_95286 "Serotonin and melatonin biosynthesis, Rattus norvegicus"
is_a: GO:0006586 ! indolalkylamine metabolic process
is_a: GO:0042401 ! cellular biogenic amine biosynthetic process
is_a: GO:0042435 ! indole-containing compound biosynthetic process

[Term]
id: GO:0046220
name: pyridine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyridine, a nitrogenous base (C5H5N) obtained from the distillation of bone oil or coal tar, and by the decomposition of certain alkaloids, as a colorless liquid with a peculiar pungent odor." [CHEBI:16227, GOC:ai]
subset: gosubset_prok
synonym: "pyridine anabolism" EXACT []
synonym: "pyridine biosynthesis" EXACT []
synonym: "pyridine formation" EXACT []
synonym: "pyridine synthesis" EXACT []
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0019507 ! pyridine metabolic process
is_a: GO:0072525 ! pyridine-containing compound biosynthetic process

[Term]
id: GO:0046221
name: pyridine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pyridine, a nitrogenous base (C5H5N) obtained from the distillation of bone oil or coal tar, and by the decomposition of certain alkaloids, as a colorless liquid with a peculiar pungent odor." [CHEBI:16227, GOC:ai]
subset: gosubset_prok
synonym: "pyridine breakdown" EXACT []
synonym: "pyridine catabolism" EXACT []
synonym: "pyridine degradation" EXACT []
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0019507 ! pyridine metabolic process
is_a: GO:0072526 ! pyridine-containing compound catabolic process

[Term]
id: GO:0046222
name: aflatoxin metabolic process
namespace: biological_process
alt_id: GO:0043389
def: "The chemical reactions and pathways involving aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450." [GOC:ai]
subset: gosubset_prok
synonym: "aflatoxin B metabolic process" NARROW [GOC:mah]
synonym: "aflatoxin metabolism" EXACT []
is_a: GO:0043385 ! mycotoxin metabolic process
is_a: GO:1901376 ! organic heteropentacyclic compound metabolic process

[Term]
id: GO:0046223
name: aflatoxin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450." [GOC:ai]
subset: gosubset_prok
synonym: "aflatoxin breakdown" EXACT []
synonym: "aflatoxin catabolism" EXACT []
synonym: "aflatoxin degradation" EXACT []
is_a: GO:0043387 ! mycotoxin catabolic process
is_a: GO:0046222 ! aflatoxin metabolic process
is_a: GO:1901377 ! organic heteropentacyclic compound catabolic process

[Term]
id: GO:0046224
name: bacteriocin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving bacteriocins, any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary." [GOC:ai]
subset: gosubset_prok
synonym: "bacteriocin metabolism" EXACT []
is_a: GO:0009404 ! toxin metabolic process
is_a: GO:0030650 ! peptide antibiotic metabolic process

[Term]
id: GO:0046225
name: bacteriocin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a bacteriocin, any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary." [GOC:ai]
subset: gosubset_prok
synonym: "bacteriocin breakdown" EXACT []
synonym: "bacteriocin catabolism" EXACT []
synonym: "bacteriocin degradation" EXACT []
is_a: GO:0009407 ! toxin catabolic process
is_a: GO:0030652 ! peptide antibiotic catabolic process
is_a: GO:0046224 ! bacteriocin metabolic process

[Term]
id: GO:0046226
name: coumarin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of coumarins, compounds derived from the phenylacrylic skeleton of cinnamic acids." [GOC:ai]
subset: gosubset_prok
synonym: "coumarin breakdown" EXACT []
synonym: "coumarin catabolism" EXACT []
synonym: "coumarin degradation" EXACT []
is_a: GO:0009804 ! coumarin metabolic process
is_a: GO:0046271 ! phenylpropanoid catabolic process
is_a: GO:0046700 ! heterocycle catabolic process

[Term]
id: GO:0046227
name: obsolete 2,4,5-trichlorophenoxyacetic acid biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2,4,5-trichlorophenoxyacetic acid, a chlorinated aromatic compound widely used as a herbicide." [GOC:ai]
comment: This term was made obsolete because 2,4,5-trichlorophenoxyacetic acid is not synthesized by living organisms and GO does not cover non-biological processes.
synonym: "2,4,5-trichlorophenoxyacetic acid anabolism" EXACT []
synonym: "2,4,5-trichlorophenoxyacetic acid biosynthesis" EXACT []
synonym: "2,4,5-trichlorophenoxyacetic acid biosynthetic process" EXACT []
synonym: "2,4,5-trichlorophenoxyacetic acid formation" EXACT []
synonym: "2,4,5-trichlorophenoxyacetic acid synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018980

[Term]
id: GO:0046228
name: 2,4,5-trichlorophenoxyacetic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 2,4,5-trichlorophenoxyacetic acid, a chlorinated aromatic compound widely used as a herbicide." [GOC:ai]
subset: gosubset_prok
synonym: "2,4,5-trichlorophenoxyacetic acid breakdown" EXACT []
synonym: "2,4,5-trichlorophenoxyacetic acid catabolism" EXACT []
synonym: "2,4,5-trichlorophenoxyacetic acid degradation" EXACT []
is_a: GO:0018980 ! 2,4,5-trichlorophenoxyacetic acid metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901502 ! ether catabolic process

[Term]
id: GO:0046229
name: obsolete 2-aminobenzenesulfonate biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2-aminobenzenesulfonate, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines." [GOC:ai]
comment: This term was made obsolete because 2-aminobenzenesulfonate is not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "2-aminobenzenesulfonate anabolism" EXACT []
synonym: "2-aminobenzenesulfonate biosynthesis" EXACT []
synonym: "2-aminobenzenesulfonate biosynthetic process" EXACT []
synonym: "2-aminobenzenesulfonate formation" EXACT []
synonym: "2-aminobenzenesulfonate synthesis" EXACT []
synonym: "2-aminobenzenesulphonate biosynthesis" EXACT []
synonym: "2-aminobenzenesulphonate biosynthetic process" EXACT []
is_obsolete: true
replaced_by: GO:0018868

[Term]
id: GO:0046230
name: 2-aminobenzenesulfonate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 2-aminobenzenesulfonate, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines." [GOC:ai]
subset: gosubset_prok
synonym: "2-aminobenzenesulfonate breakdown" EXACT []
synonym: "2-aminobenzenesulfonate catabolism" EXACT []
synonym: "2-aminobenzenesulfonate degradation" EXACT []
synonym: "2-aminobenzenesulphonate catabolic process" EXACT []
synonym: "2-aminobenzenesulphonate catabolism" EXACT []
is_a: GO:0009310 ! amine catabolic process
is_a: GO:0018868 ! 2-aminobenzenesulfonate metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0044712 ! single-organism catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process

[Term]
id: GO:0046231
name: obsolete carbazole biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of carbazole, a heterocyclic aromatic compound containing a dibenzopyrrole system that is produced during coal gasification and is present in cigarette smoke. Coal tar produced at high temperature contains an average of 1.5% carbazole. It is used widely in synthesis of dyes, pharmaceuticals, and plastics and is a suspected carcinogen." [GOC:ai]
comment: This term was made obsolete because carbazole is not synthesized by living organisms and GO does not cover non-biological processes.
synonym: "carbazole anabolism" EXACT []
synonym: "carbazole biosynthesis" EXACT []
synonym: "carbazole biosynthetic process" EXACT []
synonym: "carbazole formation" EXACT []
synonym: "carbazole synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018884

[Term]
id: GO:0046232
name: carbazole catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of carbazole, a heterocyclic aromatic compound containing a dibenzopyrrole system that is produced during coal gasification and is present in cigarette smoke. Coal tar produced at high temperature contains an average of 1.5% carbazole. It is used widely in synthesis of dyes, pharmaceuticals, and plastics and is a suspected carcinogen." [GOC:ai]
subset: gosubset_prok
synonym: "carbazole breakdown" EXACT []
synonym: "carbazole catabolism" EXACT []
synonym: "carbazole degradation" EXACT []
is_a: GO:0018884 ! carbazole metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0044270 ! cellular nitrogen compound catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process

[Term]
id: GO:0046233
name: obsolete 3-hydroxyphenylacetate biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 3-hydroxyphenylacetate, 1,3-benzenediol monoacetate, also known as resorcinol monoacetate." [http://chemfinder.cambridgesoft.com/]
comment: This term was made obsolete because 3-hydroxyphenylacetate is not synthesized by living organisms and GO does not cover non-biological processes.
synonym: "3-hydroxyphenylacetate anabolism" EXACT []
synonym: "3-hydroxyphenylacetate biosynthesis" EXACT []
synonym: "3-hydroxyphenylacetate biosynthetic process" EXACT []
synonym: "3-hydroxyphenylacetate formation" EXACT []
synonym: "3-hydroxyphenylacetate synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0019609

[Term]
id: GO:0046234
name: obsolete fluorene biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of fluorene, a tricyclic polycyclic aromatic hydrocarbon containing a five-membered ring. It is a major component of fossil fuels and their derivatives and is also a by-product of coal-conversion and energy-related industries. It is commonly found in vehicle exhaust emissions, crude oils, motor oils, coal and oil combustion products, waste incineration, and industrial effluents." [GOC:ai]
comment: This term was made obsolete because fluorene is not synthesized by living organisms and GO does not cover non-biological processes.
synonym: "fluorene anabolism" EXACT []
synonym: "fluorene biosynthesis" EXACT []
synonym: "fluorene biosynthetic process" EXACT []
synonym: "fluorene formation" EXACT []
synonym: "fluorene synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018917

[Term]
id: GO:0046235
name: gallate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of gallate, the anion of gallic acid (3,4,5-trihydroxybenzoic acid)." [GOC:ai]
subset: gosubset_prok
synonym: "gallate anabolism" EXACT []
synonym: "gallate biosynthesis" EXACT []
synonym: "gallate formation" EXACT []
synonym: "gallate synthesis" EXACT []
synonym: "gallic acid biosynthesis" EXACT []
synonym: "gallic acid biosynthetic process" EXACT []
is_a: GO:0018918 ! gallate metabolic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process

[Term]
id: GO:0046236
name: mandelate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of mandelate, the anion of mandelic acid. Mandelic acid (alpha-hydroxybenzeneacetic acid) is an 8-carbon alpha-hydroxy acid (AHA) that is used in organic chemistry and as a urinary antiseptic." [GOC:ai]
subset: gosubset_prok
synonym: "mandelate anabolism" EXACT []
synonym: "mandelate biosynthesis" EXACT []
synonym: "mandelate formation" EXACT []
synonym: "mandelate synthesis" EXACT []
is_a: GO:0018924 ! mandelate metabolic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process

[Term]
id: GO:0046237
name: obsolete phenanthrene biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of phenanthrene, a tricyclic aromatic hydrocarbon." [GOC:ai]
comment: This term was made obsolete because phenanthrene is not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "phenanthrene anabolism" EXACT []
synonym: "phenanthrene biosynthesis" EXACT []
synonym: "phenanthrene biosynthetic process" EXACT []
synonym: "phenanthrene formation" EXACT []
synonym: "phenanthrene synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018955

[Term]
id: GO:0046238
name: obsolete phthalate biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of phthalate, any ester or salt of phthalic acid." [GOC:ai]
comment: This term was made obsolete because phthalates are not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "phthalate anabolism" EXACT []
synonym: "phthalate biosynthesis" EXACT []
synonym: "phthalate biosynthetic process" EXACT []
synonym: "phthalate formation" EXACT []
synonym: "phthalate synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018963

[Term]
id: GO:0046239
name: phthalate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phthalate, the anion of phthalic acid." [GOC:ai]
subset: gosubset_prok
synonym: "phthalate breakdown" EXACT []
synonym: "phthalate catabolism" EXACT []
synonym: "phthalate degradation" EXACT []
is_a: GO:0018963 ! phthalate metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0043649 ! dicarboxylic acid catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process

[Term]
id: GO:0046240
name: obsolete xylene biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of xylene, a mixture of three colorless, aromatic hydrocarbon liquids, ortho-, meta- and para-xylene." [GOC:ai]
comment: This term was made obsolete because xylene is not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "xylene anabolism" EXACT []
synonym: "xylene biosynthesis" EXACT []
synonym: "xylene biosynthetic process" EXACT []
synonym: "xylene formation" EXACT []
synonym: "xylene synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018948

[Term]
id: GO:0046241
name: obsolete m-xylene biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of m-xylene, 1,3-dimethylbenzene, a colorless, liquid aromatic hydrocarbon." [GOC:ai]
comment: This term was made obsolete because m-xylene is not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "m-xylene anabolism" EXACT []
synonym: "m-xylene biosynthesis" EXACT []
synonym: "m-xylene biosynthetic process" EXACT []
synonym: "m-xylene formation" EXACT []
synonym: "m-xylene synthesis" EXACT []
synonym: "meta-xylene biosynthesis" EXACT []
synonym: "meta-xylene biosynthetic process" EXACT []
is_obsolete: true
replaced_by: GO:0018949

[Term]
id: GO:0046242
name: obsolete o-xylene biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of o-xylene, (1,2-dimethylbenzene) a colorless, liquid aromatic hydrocarbon." [GOC:ai]
comment: This term was made obsolete because o-xylene is not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "o-xylene anabolism" EXACT []
synonym: "o-xylene biosynthesis" EXACT []
synonym: "o-xylene biosynthetic process" EXACT []
synonym: "o-xylene formation" EXACT []
synonym: "o-xylene synthesis" EXACT []
synonym: "ortho-xylene biosynthesis" EXACT []
synonym: "ortho-xylene biosynthetic process" EXACT []
is_obsolete: true
replaced_by: GO:0018950

[Term]
id: GO:0046243
name: obsolete p-xylene biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of p-xylene (1,4-dimethylbenzene), a colorless, liquid aromatic hydrocarbon." [GOC:ai]
comment: This term was made obsolete because p-xylene is not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "p-xylene anabolism" EXACT []
synonym: "p-xylene biosynthesis" EXACT []
synonym: "p-xylene biosynthetic process" EXACT []
synonym: "p-xylene formation" EXACT []
synonym: "p-xylene synthesis" EXACT []
synonym: "para-xylene biosynthesis" EXACT []
synonym: "para-xylene biosynthetic process" EXACT []
is_obsolete: true
replaced_by: GO:0018951

[Term]
id: GO:0046244
name: salicylic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of salicylic acid (2-hydroxybenzoic acid), a derivative of benzoic acid." [GOC:ai]
subset: gosubset_prok
synonym: "salicylic acid breakdown" EXACT []
synonym: "salicylic acid catabolism" EXACT []
synonym: "salicylic acid degradation" EXACT []
is_a: GO:0009696 ! salicylic acid metabolic process
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0046245
name: obsolete styrene biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of styrene, an aromatic hydrocarbon liquid used in the manufacture of polystyrene." [GOC:ai]
comment: This term was made obsolete because styrene is not synthesized by living organisms and GO does not cover non-biological processes.
synonym: "styrene anabolism" EXACT []
synonym: "styrene biosynthesis" EXACT []
synonym: "styrene biosynthetic process" EXACT []
synonym: "styrene formation" EXACT []
synonym: "styrene synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018966

[Term]
id: GO:0046246
name: terpene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of terpenes, any of a large group of hydrocarbons made up of isoprene units." [GOC:ai]
subset: gosubset_prok
synonym: "terpene anabolism" EXACT []
synonym: "terpene biosynthesis" EXACT []
synonym: "terpene formation" EXACT []
synonym: "terpene synthesis" EXACT []
is_a: GO:0008299 ! isoprenoid biosynthetic process
is_a: GO:0042214 ! terpene metabolic process

[Term]
id: GO:0046247
name: terpene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of terpenes, any of a large group of hydrocarbons made up of isoprene units." [GOC:ai]
subset: gosubset_prok
synonym: "terpene breakdown" EXACT []
synonym: "terpene catabolism" EXACT []
synonym: "terpene degradation" EXACT []
is_a: GO:0008300 ! isoprenoid catabolic process
is_a: GO:0042214 ! terpene metabolic process

[Term]
id: GO:0046248
name: alpha-pinene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of alpha-pinene, a monoterpene that may be a significant factor affecting bacterial activities in nature." [GOC:ai]
subset: gosubset_prok
synonym: "alpha-pinene anabolism" EXACT []
synonym: "alpha-pinene biosynthesis" EXACT []
synonym: "alpha-pinene formation" EXACT []
synonym: "alpha-pinene synthesis" EXACT []
is_a: GO:0018867 ! alpha-pinene metabolic process
is_a: GO:0043693 ! monoterpene biosynthetic process

[Term]
id: GO:0046249
name: alpha-pinene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of alpha-pinene, a monoterpene that may be a significant factor affecting bacterial activities in nature." [GOC:ai]
subset: gosubset_prok
synonym: "alpha-pinene breakdown" EXACT []
synonym: "alpha-pinene catabolism" EXACT []
synonym: "alpha-pinene degradation" EXACT []
is_a: GO:0018867 ! alpha-pinene metabolic process
is_a: GO:0033074 ! pinene catabolic process

[Term]
id: GO:0046250
name: limonene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of limonene (4-isopropenyl-1-methyl-cyclohexene), a monocyclic monoterpene." [GOC:ai]
subset: gosubset_prok
synonym: "limonene anabolism" EXACT []
synonym: "limonene biosynthesis" EXACT []
synonym: "limonene formation" EXACT []
synonym: "limonene synthesis" EXACT []
is_a: GO:0018923 ! limonene metabolic process
is_a: GO:0043693 ! monoterpene biosynthetic process

[Term]
id: GO:0046251
name: limonene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of limonene (4-isopropenyl-1-methyl-cyclohexene), a monocyclic monoterpene." [GOC:ai]
subset: gosubset_prok
synonym: "limonene breakdown" EXACT []
synonym: "limonene catabolism" EXACT []
synonym: "limonene degradation" EXACT []
is_a: GO:0018923 ! limonene metabolic process
is_a: GO:0043694 ! monoterpene catabolic process

[Term]
id: GO:0046252
name: toluene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products." [GOC:ai, PMID:6508079]
comment: This term was reinstated from obsolete.
synonym: "toluene anabolism" EXACT []
synonym: "toluene biosynthesis" EXACT []
synonym: "toluene formation" EXACT []
synonym: "toluene synthesis" EXACT []
is_a: GO:0018970 ! toluene metabolic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process

[Term]
id: GO:0046253
name: anaerobic toluene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products, in the absence of oxygen." [GOC:ai, PMID:8573493]
comment: This term was reinstated from obsolete.
synonym: "anaerobic toluene anabolism" EXACT []
synonym: "anaerobic toluene biosynthesis" EXACT []
synonym: "anaerobic toluene formation" EXACT []
synonym: "anaerobic toluene synthesis" EXACT []
is_a: GO:0018971 ! anaerobic toluene metabolic process
is_a: GO:0046252 ! toluene biosynthetic process

[Term]
id: GO:0046254
name: anaerobic toluene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products, in the absence of oxygen." [GOC:ai]
subset: gosubset_prok
synonym: "anaerobic toluene breakdown" EXACT []
synonym: "anaerobic toluene catabolism" EXACT []
synonym: "anaerobic toluene degradation" EXACT []
xref: MetaCyc:PWY-81
is_a: GO:0042203 ! toluene catabolic process

[Term]
id: GO:0046255
name: obsolete 2,4,6-trinitrotoluene biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene." [GOC:ai]
comment: This term was made obsolete because 2,4,6-trinitrotoluene is not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "2,4,6-trinitrotoluene anabolism" EXACT []
synonym: "2,4,6-trinitrotoluene biosynthesis" EXACT []
synonym: "2,4,6-trinitrotoluene biosynthetic process" EXACT []
synonym: "2,4,6-trinitrotoluene formation" EXACT []
synonym: "2,4,6-trinitrotoluene synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018974

[Term]
id: GO:0046256
name: 2,4,6-trinitrotoluene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid." [GOC:ai]
subset: gosubset_prok
synonym: "2,4,6-trinitrotoluene breakdown" EXACT []
synonym: "2,4,6-trinitrotoluene catabolism" EXACT []
synonym: "2,4,6-trinitrotoluene degradation" EXACT []
is_a: GO:0018974 ! 2,4,6-trinitrotoluene metabolic process
is_a: GO:0046260 ! trinitrotoluene catabolic process

[Term]
id: GO:0046257
name: obsolete anaerobic 2,4,6-trinitrotoluene biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid, in the absence of oxygen." [GOC:ai]
comment: This term was made obsolete because 2,4,6-trinitrotoluene is not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "anaerobic 2,4,6-trinitrotoluene anabolism" EXACT []
synonym: "anaerobic 2,4,6-trinitrotoluene biosynthesis" EXACT []
synonym: "anaerobic 2,4,6-trinitrotoluene biosynthetic process" EXACT []
synonym: "anaerobic 2,4,6-trinitrotoluene formation" EXACT []
synonym: "anaerobic 2,4,6-trinitrotoluene synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018975

[Term]
id: GO:0046258
name: anaerobic 2,4,6-trinitrotoluene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid, in the absence of oxygen." [GOC:ai]
subset: gosubset_prok
synonym: "anaerobic 2,4,6-trinitrotoluene breakdown" EXACT []
synonym: "anaerobic 2,4,6-trinitrotoluene catabolism" EXACT []
synonym: "anaerobic 2,4,6-trinitrotoluene degradation" EXACT []
is_a: GO:0018975 ! anaerobic 2,4,6-trinitrotoluene metabolic process
is_a: GO:0046256 ! 2,4,6-trinitrotoluene catabolic process

[Term]
id: GO:0046259
name: obsolete trinitrotoluene biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of trinitrotoluene, a methylated benzene molecule with three NO2 groups attached to it." [GOC:ai]
comment: This term was made obsolete because trinitrotoluene is not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "trinitrotoluene anabolism" EXACT []
synonym: "trinitrotoluene biosynthesis" EXACT []
synonym: "trinitrotoluene biosynthetic process" EXACT []
synonym: "trinitrotoluene formation" EXACT []
synonym: "trinitrotoluene synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018973

[Term]
id: GO:0046260
name: trinitrotoluene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of trinitrotoluene, a methylated benzene entity with three NO2 groups attached to it. This includes the explosive TNT, 1-methyl-2,4,6-trinitrobenzene." [GOC:ai]
subset: gosubset_prok
synonym: "trinitrotoluene breakdown" EXACT []
synonym: "trinitrotoluene catabolism" EXACT []
synonym: "trinitrotoluene degradation" EXACT []
is_a: GO:0018973 ! trinitrotoluene metabolic process
is_a: GO:0046263 ! nitrotoluene catabolic process

[Term]
id: GO:0046261
name: obsolete 4-nitrotoluene biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 4-nitrotoluene, 1-methyl-4-nitrobenzene." [GOC:ai]
comment: This term was made obsolete because 4-nitrotoluene is not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "4-nitrotoluene anabolism" EXACT []
synonym: "4-nitrotoluene biosynthesis" EXACT []
synonym: "4-nitrotoluene biosynthetic process" EXACT []
synonym: "4-nitrotoluene formation" EXACT []
synonym: "4-nitrotoluene synthesis" EXACT []
synonym: "4NT biosynthesis" EXACT []
synonym: "4NT biosynthetic process" EXACT []
is_obsolete: true
replaced_by: GO:0019257

[Term]
id: GO:0046262
name: obsolete nitrotoluene biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of nitrotoluene, any methylbenzene molecule with NO2 group(s) attached." [GOC:ai]
comment: This term was made obsolete because nitrotoluene is not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "nitrotoluene anabolism" EXACT []
synonym: "nitrotoluene biosynthesis" EXACT []
synonym: "nitrotoluene biosynthetic process" EXACT []
synonym: "nitrotoluene formation" EXACT []
synonym: "nitrotoluene synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0019326

[Term]
id: GO:0046263
name: nitrotoluene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of nitrotoluene, any methylbenzene molecule with NO2 group(s) attached." [GOC:ai]
subset: gosubset_prok
synonym: "nitrotoluene breakdown" EXACT []
synonym: "nitrotoluene catabolism" EXACT []
synonym: "nitrotoluene degradation" EXACT []
is_a: GO:0019326 ! nitrotoluene metabolic process
is_a: GO:0072491 ! toluene-containing compound catabolic process

[Term]
id: GO:0046264
name: obsolete thiocyanate biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of thiocyanate, any anion or salt of thiocyanic acid." [GOC:ai]
comment: This term was made obsolete because thiocyanates are not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "thiocyanate anabolism" EXACT []
synonym: "thiocyanate biosynthesis" EXACT []
synonym: "thiocyanate biosynthetic process" EXACT []
synonym: "thiocyanate formation" EXACT []
synonym: "thiocyanate synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018969

[Term]
id: GO:0046265
name: thiocyanate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of thiocyanate, any anion of thiocyanic acid." [GOC:ai]
subset: gosubset_prok
synonym: "thiocyanate breakdown" EXACT []
synonym: "thiocyanate catabolism" EXACT []
synonym: "thiocyanate degradation" EXACT []
is_a: GO:0018969 ! thiocyanate metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0044282 ! small molecule catabolic process
is_a: GO:1901575 ! organic substance catabolic process

[Term]
id: GO:0046266
name: obsolete triethanolamine biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of triethanolamine, a combustible, hygroscopic, colorless liquid commonly used in dry-cleaning solutions, cosmetics, detergents, textile processing, wool scouring, and as a corrosion inhibitor and pharmaceutical alkalizing agent." [GOC:ai]
comment: This term was made obsolete because triethanolamine is not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "triethanolamine anabolism" EXACT []
synonym: "triethanolamine biosynthesis" EXACT []
synonym: "triethanolamine biosynthetic process" EXACT []
synonym: "triethanolamine formation" EXACT []
synonym: "triethanolamine synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018981

[Term]
id: GO:0046267
name: triethanolamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of triethanolamine, a combustible, hygroscopic, colorless liquid commonly used in dry-cleaning solutions, cosmetics, detergents, textile processing, wool scouring, and as a corrosion inhibitor and pharmaceutical alkalizing agent." [GOC:ai]
subset: gosubset_prok
synonym: "triethanolamine breakdown" EXACT []
synonym: "triethanolamine catabolism" EXACT []
synonym: "triethanolamine degradation" EXACT []
is_a: GO:0018981 ! triethanolamine metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0046164 ! alcohol catabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process

[Term]
id: GO:0046268
name: obsolete toluene-4-sulfonate biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of toluene-4-sulfonate, 4-methylbenzenesulfonate, the anion of sulfonic acid attached to a methylbenzene molecule." [GOC:ai]
comment: This term was made obsolete because toluene-4-sulfonate is not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "4-toluenesulfonate biosynthesis" EXACT []
synonym: "4-toluenesulfonate biosynthetic process" EXACT []
synonym: "toluene-4-sulfonate anabolism" EXACT []
synonym: "toluene-4-sulfonate biosynthesis" EXACT []
synonym: "toluene-4-sulfonate biosynthetic process" EXACT []
synonym: "toluene-4-sulfonate formation" EXACT []
synonym: "toluene-4-sulfonate synthesis" EXACT []
synonym: "toluene-4-sulphonate biosynthesis" EXACT []
synonym: "toluene-4-sulphonate biosynthetic process" EXACT []
is_obsolete: true
replaced_by: GO:0018972

[Term]
id: GO:0046269
name: toluene-4-sulfonate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of toluene-4-sulfonate, 4-methylbenzenesulfonate, the anion of sulfonic acid attached to a methylbenzene molecule." [GOC:ai]
subset: gosubset_prok
synonym: "4-toluenesulfonate catabolic process" EXACT []
synonym: "4-toluenesulfonate catabolism" EXACT []
synonym: "toluene-4-sulfonate breakdown" EXACT []
synonym: "toluene-4-sulfonate catabolism" EXACT []
synonym: "toluene-4-sulfonate degradation" EXACT []
synonym: "toluene-4-sulphonate catabolic process" EXACT []
synonym: "toluene-4-sulphonate catabolism" EXACT []
is_a: GO:0018972 ! toluene-4-sulfonate metabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0044282 ! small molecule catabolic process
is_a: GO:0072491 ! toluene-containing compound catabolic process

[Term]
id: GO:0046270
name: obsolete 4-toluenecarboxylate biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 4-toluenecarboxylate, 4-methylbenzenecarboxylate, the anion of carboxylic acid attached to a methylbenzene molecule." [GOC:ai]
comment: This term was made obsolete because 4-toluenecarboxylate is not synthesized by living organisms and GO does not cover non-biological processes.
synonym: "4-toluenecarboxylate anabolism" EXACT []
synonym: "4-toluenecarboxylate biosynthesis" EXACT []
synonym: "4-toluenecarboxylate biosynthetic process" EXACT []
synonym: "4-toluenecarboxylate formation" EXACT []
synonym: "4-toluenecarboxylate synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0019611

[Term]
id: GO:0046271
name: phenylpropanoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of aromatic derivatives of trans-cinnamic acid." [GOC:ai]
subset: gosubset_prok
synonym: "phenylpropanoid breakdown" EXACT []
synonym: "phenylpropanoid catabolism" EXACT []
synonym: "phenylpropanoid degradation" EXACT []
is_a: GO:0009698 ! phenylpropanoid metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0044712 ! single-organism catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process

[Term]
id: GO:0046272
name: stilbene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of stilbenes, a class of polyketide compounds formed from cinnamic acid and three molecules of malonyl CoA." [GOC:ai]
subset: gosubset_prok
synonym: "stilbene breakdown" EXACT []
synonym: "stilbene catabolism" EXACT []
synonym: "stilbene degradation" EXACT []
is_a: GO:0009810 ! stilbene metabolic process
is_a: GO:0046271 ! phenylpropanoid catabolic process

[Term]
id: GO:0046273
name: lignan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lignans, any member of a class of plant metabolites related to lignins. Lignans are usually found as phenylpropanoid dimers in which the phenylpropanoid units are linked tail to tail and thus having a 2,3 dibenzylbutane skeleton, but higher oligomers can also exist." [GOC:jl, PMID:10074466]
subset: gosubset_prok
synonym: "lignan breakdown" EXACT []
synonym: "lignan catabolism" EXACT []
synonym: "lignan degradation" EXACT []
is_a: GO:0009806 ! lignan metabolic process
is_a: GO:0046271 ! phenylpropanoid catabolic process

[Term]
id: GO:0046274
name: lignin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units." [GOC:ai]
subset: gosubset_prok
synonym: "lignin breakdown" EXACT []
synonym: "lignin catabolism" EXACT []
synonym: "lignin degradation" EXACT []
is_a: GO:0009808 ! lignin metabolic process
is_a: GO:0046271 ! phenylpropanoid catabolic process

[Term]
id: GO:0046275
name: flavonoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of flavonoids, a group of phenolic derivatives containing a flavan skeleton." [GOC:ai]
subset: gosubset_prok
synonym: "flavonoid breakdown" EXACT []
synonym: "flavonoid catabolism" EXACT []
synonym: "flavonoid degradation" EXACT []
is_a: GO:0009812 ! flavonoid metabolic process
is_a: GO:1901575 ! organic substance catabolic process

[Term]
id: GO:0046276
name: methylgallate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of methylgallate, trihydroxymethylbenzoate, the anion of methylgallic acid." [GOC:ai]
subset: gosubset_prok
synonym: "methylgallate breakdown" EXACT []
synonym: "methylgallate catabolism" EXACT []
synonym: "methylgallate degradation" EXACT []
xref: MetaCyc:METHYLGALLATE-DEGRADATION-PWY
is_a: GO:0019489 ! methylgallate metabolic process
is_a: GO:0019614 ! catechol-containing compound catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0046277
name: methylgallate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of methylgallate, trihydroxymethylbenzoate, the anion of methylgallic acid." [GOC:ai]
subset: gosubset_prok
synonym: "methylgallate anabolism" EXACT []
synonym: "methylgallate biosynthesis" EXACT []
synonym: "methylgallate formation" EXACT []
synonym: "methylgallate synthesis" EXACT []
is_a: GO:0009713 ! catechol-containing compound biosynthetic process
is_a: GO:0019489 ! methylgallate metabolic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process

[Term]
id: GO:0046278
name: 3,4-dihydroxybenzoate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving protocatechuate, the anion of protocatechuic acid (3,4-dihydroxybenzoic acid)." [GOC:ai, http://chemfinder.cambridgesoft.com/]
subset: gosubset_prok
synonym: "protocatechuate metabolic process" EXACT [CHEBI:36241]
synonym: "protocatechuate metabolism" EXACT []
is_a: GO:0009712 ! catechol-containing compound metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:0046279
name: 3,4-dihydroxybenzoate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 3,4-dihydroxybenzoate." [GOC:ai]
subset: gosubset_prok
synonym: "protocatechuate anabolism" EXACT []
synonym: "protocatechuate biosynthesis" EXACT []
synonym: "protocatechuate biosynthetic process" EXACT [CHEBI:36241]
synonym: "protocatechuate formation" EXACT []
synonym: "protocatechuate synthesis" EXACT []
is_a: GO:0009713 ! catechol-containing compound biosynthetic process
is_a: GO:0046278 ! 3,4-dihydroxybenzoate metabolic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process

[Term]
id: GO:0046280
name: chalcone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of chalcone, phenyl steryl ketone or its hydroxylated derivatives." [GOC:ai]
subset: gosubset_prok
synonym: "chalcone breakdown" EXACT []
synonym: "chalcone catabolism" EXACT []
synonym: "chalcone degradation" EXACT []
is_a: GO:0009714 ! chalcone metabolic process
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:0046271 ! phenylpropanoid catabolic process

[Term]
id: GO:0046281
name: cinnamic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cinnamic acid, 3-phenyl-2-propenoic acid." [GOC:ai]
subset: gosubset_prok
synonym: "cinnamic acid breakdown" EXACT []
synonym: "cinnamic acid catabolism" EXACT []
synonym: "cinnamic acid degradation" EXACT []
synonym: "cinnamylic acid catabolic process" EXACT []
synonym: "cinnamylic acid catabolism" EXACT []
synonym: "phenylacrylic acid catabolic process" EXACT []
synonym: "phenylacrylic acid catabolism" EXACT []
is_a: GO:0009803 ! cinnamic acid metabolic process
is_a: GO:0046271 ! phenylpropanoid catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0046282
name: cinnamic acid ester catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ester derivatives of cinnamic acid, phenylpropenoic acid." [GOC:ai]
subset: gosubset_prok
synonym: "cinnamic acid ester breakdown" EXACT []
synonym: "cinnamic acid ester catabolism" EXACT []
synonym: "cinnamic acid ester degradation" EXACT []
is_a: GO:0009801 ! cinnamic acid ester metabolic process
is_a: GO:0046271 ! phenylpropanoid catabolic process

[Term]
id: GO:0046283
name: anthocyanin-containing compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins that occur in plants. They are responsible from most of the scarlet, purple, mauve and blue coloring in higher plants, especially of flowers." [ISBN:0198506732]
subset: gosubset_prok
synonym: "anthocyanin metabolic process" EXACT []
synonym: "anthocyanin metabolism" EXACT []
is_a: GO:0009812 ! flavonoid metabolic process
is_a: GO:0042440 ! pigment metabolic process

[Term]
id: GO:0046284
name: anthocyanin-containing compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins." [GOC:ai]
subset: gosubset_prok
synonym: "anthocyanin breakdown" EXACT []
synonym: "anthocyanin catabolic process" EXACT []
synonym: "anthocyanin catabolism" EXACT []
synonym: "anthocyanin degradation" EXACT []
is_a: GO:0016139 ! glycoside catabolic process
is_a: GO:0046149 ! pigment catabolic process
is_a: GO:0046275 ! flavonoid catabolic process
is_a: GO:0046283 ! anthocyanin-containing compound metabolic process

[Term]
id: GO:0046285
name: flavonoid phytoalexin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving flavonoid phytoalexins, a group of water-soluble phenolic derivatives containing a flavan skeleton, which possess antibiotic activity and are produced by plant tissues in response to infection." [ISBN:0198506732]
subset: gosubset_prok
synonym: "flavonoid phytoalexin metabolism" EXACT []
is_a: GO:0009812 ! flavonoid metabolic process

[Term]
id: GO:0046286
name: flavonoid phytoalexin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of flavonoid phytoalexins, a group of water-soluble phenolic derivatives containing a flavan skeleton, which possess antibiotic activity and are produced by plant tissues in response to infection." [GOC:ai]
subset: gosubset_prok
synonym: "flavonoid phytoalexin breakdown" EXACT []
synonym: "flavonoid phytoalexin catabolism" EXACT []
synonym: "flavonoid phytoalexin degradation" EXACT []
is_a: GO:0046275 ! flavonoid catabolic process
is_a: GO:0046285 ! flavonoid phytoalexin metabolic process
is_a: GO:0052316 ! phytoalexin catabolic process

[Term]
id: GO:0046287
name: isoflavonoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving isoflavonoids, a group of water-soluble phenolic derivatives, isomeric with flavonoids, containing a flavan skeleton. They are differentiated from flavonoids by the point of attachment of the aromatic ring group." [CHEBI:50753, GOC:ai]
subset: gosubset_prok
synonym: "isoflavonoid metabolism" EXACT []
is_a: GO:0009698 ! phenylpropanoid metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0046288
name: isoflavonoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of isoflavonoids, a group of water-soluble phenolic derivatives, isomeric with flavonoids." [GOC:ai]
subset: gosubset_prok
synonym: "isoflavonoid breakdown" EXACT []
synonym: "isoflavonoid catabolism" EXACT []
synonym: "isoflavonoid degradation" EXACT []
is_a: GO:0046271 ! phenylpropanoid catabolic process
is_a: GO:0046287 ! isoflavonoid metabolic process
is_a: GO:0046700 ! heterocycle catabolic process

[Term]
id: GO:0046289
name: isoflavonoid phytoalexin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving isoflavonoid phytoalexins, a group of water-soluble phenolic derivatives isomeric with flavonoids that possess antibiotic activity and are produced by plant tissues in response to infection." [GOC:ai]
subset: gosubset_prok
synonym: "isoflavonoid phytoalexin metabolism" EXACT []
is_a: GO:0046287 ! isoflavonoid metabolic process
is_a: GO:0052314 ! phytoalexin metabolic process

[Term]
id: GO:0046290
name: isoflavonoid phytoalexin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of isoflavonoid phytoalexins, a group of water-soluble phenolic derivatives isomeric with flavonoids that possess antibiotic activity and are produced by plant tissues in response to infection." [GOC:ai]
subset: gosubset_prok
synonym: "isoflavonoid phytoalexin breakdown" EXACT []
synonym: "isoflavonoid phytoalexin catabolism" EXACT []
synonym: "isoflavonoid phytoalexin degradation" EXACT []
is_a: GO:0046288 ! isoflavonoid catabolic process
is_a: GO:0046289 ! isoflavonoid phytoalexin metabolic process
is_a: GO:0052316 ! phytoalexin catabolic process

[Term]
id: GO:0046291
name: obsolete 6-hydroxycineole biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 6-hydroxycineole (6-hydroxy-1,8-epoxy-p-menthane), a hydrocarbon with the formula C10H18O2." [GOC:ai]
comment: This term was made obsolete because 6-hydroxycineole is not synthesized by living organisms and GO does not cover non-biological processes.
synonym: "6-endo-hydroxycineole biosynthesis" EXACT []
synonym: "6-endo-hydroxycineole biosynthetic process" EXACT []
synonym: "6-hydroxycineole anabolism" EXACT []
synonym: "6-hydroxycineole biosynthesis" EXACT []
synonym: "6-hydroxycineole biosynthetic process" EXACT []
synonym: "6-hydroxycineole formation" EXACT []
synonym: "6-hydroxycineole synthesis" EXACT []
synonym: "hydroxycineol biosynthesis" EXACT []
synonym: "hydroxycineol biosynthetic process" EXACT []
is_obsolete: true
replaced_by: GO:0019638

[Term]
id: GO:0046292
name: formaldehyde metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving formaldehyde (methanal, H2C=O), a colorless liquid or gas with a pungent odor, commonly used as a fixative or an antibacterial agent." [CHEBI:16842, GOC:ai, http://chemfinder.cambridgesoft.com/]
subset: gosubset_prok
synonym: "formaldehyde metabolism" EXACT []
synonym: "methanal metabolic process" EXACT []
synonym: "methanal metabolism" EXACT []
is_a: GO:0006081 ! cellular aldehyde metabolic process
is_a: GO:0044281 ! small molecule metabolic process

[Term]
id: GO:0046293
name: formaldehyde biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of formaldehyde (methanal, H2C=O), the simplest aldehyde." [GOC:ai]
subset: gosubset_prok
synonym: "formaldehyde anabolism" EXACT []
synonym: "formaldehyde biosynthesis" EXACT []
synonym: "formaldehyde formation" EXACT []
synonym: "formaldehyde synthesis" EXACT []
synonym: "methanal biosynthesis" EXACT []
synonym: "methanal biosynthetic process" EXACT []
is_a: GO:0044283 ! small molecule biosynthetic process
is_a: GO:0046184 ! aldehyde biosynthetic process
is_a: GO:0046292 ! formaldehyde metabolic process

[Term]
id: GO:0046294
name: formaldehyde catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of formaldehyde (methanal, H2C=O), the simplest aldehyde." [GOC:ai]
subset: gosubset_prok
synonym: "formaldehyde breakdown" EXACT []
synonym: "formaldehyde catabolism" EXACT []
synonym: "formaldehyde degradation" EXACT []
synonym: "methanal catabolic process" EXACT []
synonym: "methanal catabolism" EXACT []
is_a: GO:0044282 ! small molecule catabolic process
is_a: GO:0046185 ! aldehyde catabolic process
is_a: GO:0046292 ! formaldehyde metabolic process

[Term]
id: GO:0046295
name: glycolate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycolate, the anion of hydroxyethanoic acid (glycolic acid)." [GOC:ai]
subset: gosubset_prok
synonym: "glycolate anabolism" EXACT []
synonym: "glycolate biosynthesis" EXACT []
synonym: "glycolate formation" EXACT []
synonym: "glycolate synthesis" EXACT []
is_a: GO:0009441 ! glycolate metabolic process
is_a: GO:0034309 ! primary alcohol biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process

[Term]
id: GO:0046296
name: glycolate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycolate, the anion of hydroxyethanoic acid (glycolic acid)." [GOC:ai]
subset: gosubset_prok
synonym: "glycolate breakdown" EXACT []
synonym: "glycolate catabolism" EXACT []
synonym: "glycolate degradation" EXACT []
is_a: GO:0009441 ! glycolate metabolic process
is_a: GO:0034310 ! primary alcohol catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0046297
name: obsolete 2,4-dichlorobenzoate biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2,4-dichlorobenzoate, a chlorinated aromatic compound which is a key intermediate in the aerobic degradation of polychlorinated biphenyls (PCBs)." [GOC:ai]
comment: This term was made obsolete because 2,4-dichlorobenzoate is not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "2,4-dichlorobenzoate anabolism" EXACT []
synonym: "2,4-dichlorobenzoate biosynthesis" EXACT []
synonym: "2,4-dichlorobenzoate biosynthetic process" EXACT []
synonym: "2,4-dichlorobenzoate formation" EXACT []
synonym: "2,4-dichlorobenzoate synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018898

[Term]
id: GO:0046298
name: 2,4-dichlorobenzoate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 2,4-dichlorobenzoate, a chlorinated aromatic compound which is a key intermediate in the aerobic degradation of polychlorinated biphenyls (PCBs)." [GOC:ai]
subset: gosubset_prok
synonym: "2,4-dichlorobenzoate breakdown" EXACT []
synonym: "2,4-dichlorobenzoate catabolism" EXACT []
synonym: "2,4-dichlorobenzoate degradation" EXACT []
is_a: GO:0018898 ! 2,4-dichlorobenzoate metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process

[Term]
id: GO:0046299
name: obsolete 2,4-dichlorophenoxyacetic acid biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2,4-dichlorophenoxyacetic acid, a chlorinated phenoxy compound which functions as a systemic herbicide and is used to control many types of broadleaf weeds." [GOC:ai]
comment: This term was made obsolete because 2,4-dichlorophenoxyacetic acid is not synthesized by living organisms and GO does not cover non-biological processes.
synonym: "2,4-dichlorophenoxyacetic acid anabolism" EXACT []
synonym: "2,4-dichlorophenoxyacetic acid biosynthesis" EXACT []
synonym: "2,4-dichlorophenoxyacetic acid biosynthetic process" EXACT []
synonym: "2,4-dichlorophenoxyacetic acid formation" EXACT []
synonym: "2,4-dichlorophenoxyacetic acid synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018901

[Term]
id: GO:0046300
name: 2,4-dichlorophenoxyacetic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 2,4-dichlorophenoxyacetic acid, a chlorinated phenoxy compound which functions as a systemic herbicide and is used to control many types of broadleaf weeds." [GOC:ai]
subset: gosubset_prok
synonym: "2,4-dichlorophenoxyacetic acid breakdown" EXACT []
synonym: "2,4-dichlorophenoxyacetic acid catabolism" EXACT []
synonym: "2,4-dichlorophenoxyacetic acid degradation" EXACT []
is_a: GO:0018901 ! 2,4-dichlorophenoxyacetic acid metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901502 ! ether catabolic process

[Term]
id: GO:0046301
name: obsolete 2-chloro-N-isopropylacetanilide biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2-chloro-N-isopropylacetanilide, an acylanide herbicide widely used to protect corn, onion, cabbage, rose bushes, and ornamental plants." [GOC:ai]
comment: This term was made obsolete because 2-chloro-N-isopropylacetanilide is not synthesized by living organisms and GO does not cover non-biological processes.
synonym: "2-chloro-N-isopropylacetanilide anabolism" EXACT []
synonym: "2-chloro-N-isopropylacetanilide biosynthesis" EXACT []
synonym: "2-chloro-N-isopropylacetanilide biosynthetic process" EXACT []
synonym: "2-chloro-N-isopropylacetanilide formation" EXACT []
synonym: "2-chloro-N-isopropylacetanilide synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018889

[Term]
id: GO:0046302
name: 2-chloro-N-isopropylacetanilide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 2-chloro-N-isopropylacetanilide, an acylanide herbicide widely used to protect corn, onion, cabbage, rose bushes, and ornamental plants." [GOC:ai]
subset: gosubset_prok
synonym: "2-chloro-N-isopropylacetanilide breakdown" EXACT []
synonym: "2-chloro-N-isopropylacetanilide catabolism" EXACT []
synonym: "2-chloro-N-isopropylacetanilide degradation" EXACT []
is_a: GO:0018889 ! 2-chloro-N-isopropylacetanilide metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process

[Term]
id: GO:0046303
name: obsolete 2-nitropropane biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2-nitropropane, a clear, colorless liquid with a mild, fruity odor." [GOC:ai]
comment: This term was made obsolete because 2-nitropropane is not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "2-nitropropane anabolism" EXACT []
synonym: "2-nitropropane biosynthesis" EXACT []
synonym: "2-nitropropane biosynthetic process" EXACT []
synonym: "2-nitropropane formation" EXACT []
synonym: "2-nitropropane synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018938

[Term]
id: GO:0046304
name: 2-nitropropane catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 2-nitropropane, a clear, colorless liquid with a mild, fruity odor." [GOC:ai]
subset: gosubset_prok
synonym: "2-nitropropane breakdown" EXACT []
synonym: "2-nitropropane catabolism" EXACT []
synonym: "2-nitropropane degradation" EXACT []
is_a: GO:0018938 ! 2-nitropropane metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0044270 ! cellular nitrogen compound catabolic process

[Term]
id: GO:0046305
name: alkanesulfonate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon group." [GOC:ai]
subset: gosubset_prok
synonym: "alkanesulfonate anabolism" EXACT []
synonym: "alkanesulfonate biosynthesis" EXACT []
synonym: "alkanesulfonate formation" EXACT []
synonym: "alkanesulfonate synthesis" EXACT []
synonym: "alkanesulphonate biosynthesis" EXACT []
synonym: "alkanesulphonate biosynthetic process" EXACT []
is_a: GO:0019694 ! alkanesulfonate metabolic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:1901576 ! organic substance biosynthetic process

[Term]
id: GO:0046306
name: alkanesulfonate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon group." [GOC:ai]
subset: gosubset_prok
synonym: "alkanesulfonate breakdown" EXACT []
synonym: "alkanesulfonate catabolism" EXACT []
synonym: "alkanesulfonate degradation" EXACT []
synonym: "alkanesulphonate catabolic process" EXACT []
synonym: "alkanesulphonate catabolism" EXACT []
is_a: GO:0019694 ! alkanesulfonate metabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0044712 ! single-organism catabolic process
is_a: GO:1901575 ! organic substance catabolic process

[Term]
id: GO:0046307
name: Z-phenylacetaldoxime biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of Z-phenylacetaldoxime, a member of the glucosinolate group of compounds." [GOC:ai]
subset: gosubset_prok
synonym: "Z-phenylacetaldoxime anabolism" EXACT []
synonym: "Z-phenylacetaldoxime biosynthesis" EXACT []
synonym: "Z-phenylacetaldoxime formation" EXACT []
synonym: "Z-phenylacetaldoxime synthesis" EXACT []
is_a: GO:0018983 ! Z-phenylacetaldoxime metabolic process
is_a: GO:1901576 ! organic substance biosynthetic process

[Term]
id: GO:0046308
name: Z-phenylacetaldoxime catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of Z-phenylacetaldoxime, a member of the glucosinolate group of compounds." [GOC:ai]
subset: gosubset_prok
synonym: "Z-phenylacetaldoxime breakdown" EXACT []
synonym: "Z-phenylacetaldoxime catabolism" EXACT []
synonym: "Z-phenylacetaldoxime degradation" EXACT []
is_a: GO:0018983 ! Z-phenylacetaldoxime metabolic process
is_a: GO:1901575 ! organic substance catabolic process

[Term]
id: GO:0046309
name: 1,3-dichloro-2-propanol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 1,3-dichloro-2-propanol (DCP), a halohydrin suspected of being carcinogenic, mutagenic and genotoxic." [GOC:ai]
subset: gosubset_prok
synonym: "1,3-dichloro-2-propanol anabolism" EXACT []
synonym: "1,3-dichloro-2-propanol biosynthesis" EXACT []
synonym: "1,3-dichloro-2-propanol formation" EXACT []
synonym: "1,3-dichloro-2-propanol synthesis" EXACT []
is_a: GO:0018902 ! 1,3-dichloro-2-propanol metabolic process
is_a: GO:0044108 ! cellular alcohol biosynthetic process
is_a: GO:1902653 ! secondary alcohol biosynthetic process

[Term]
id: GO:0046310
name: 1,3-dichloro-2-propanol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 1,3-dichloro-2-propanol (DCP), a halohydrin suspected of being carcinogenic, mutagenic and genotoxic." [GOC:ai]
subset: gosubset_prok
synonym: "1,3-dichloro-2-propanol breakdown" EXACT []
synonym: "1,3-dichloro-2-propanol catabolism" EXACT []
synonym: "1,3-dichloro-2-propanol degradation" EXACT []
is_a: GO:0018902 ! 1,3-dichloro-2-propanol metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0044109 ! cellular alcohol catabolic process

[Term]
id: GO:0046311
name: prenylcysteine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue." [GOC:ai]
subset: gosubset_prok
synonym: "prenylcysteine anabolism" EXACT []
synonym: "prenylcysteine biosynthesis" EXACT []
synonym: "prenylcysteine formation" EXACT []
synonym: "prenylcysteine synthesis" EXACT []
is_a: GO:0000097 ! sulfur amino acid biosynthetic process
is_a: GO:0030329 ! prenylcysteine metabolic process
is_a: GO:0042398 ! cellular modified amino acid biosynthetic process

[Term]
id: GO:0046312
name: phosphoarginine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phosphoarginine, a phosphorylated derivative of the amino acid arginine." [GOC:ai]
subset: gosubset_prok
synonym: "phosphoarginine anabolism" EXACT []
synonym: "phosphoarginine biosynthesis" EXACT []
synonym: "phosphoarginine formation" EXACT []
synonym: "phosphoarginine synthesis" EXACT []
is_a: GO:0006604 ! phosphoarginine metabolic process
is_a: GO:0042396 ! phosphagen biosynthetic process
is_a: GO:1901607 ! alpha-amino acid biosynthetic process

[Term]
id: GO:0046313
name: phosphoarginine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phosphoarginine, a phosphorylated derivative of the amino acid arginine." [GOC:ai]
subset: gosubset_prok
synonym: "phosphoarginine breakdown" EXACT []
synonym: "phosphoarginine catabolism" EXACT []
synonym: "phosphoarginine degradation" EXACT []
is_a: GO:0006604 ! phosphoarginine metabolic process
is_a: GO:0042397 ! phosphagen catabolic process
is_a: GO:1901606 ! alpha-amino acid catabolic process

[Term]
id: GO:0046314
name: phosphocreatine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phosphocreatine, a phosphagen of creatine which is synthesized and broken down by creatine phosphokinase." [GOC:ai]
subset: gosubset_prok
synonym: "phosphocreatine anabolism" EXACT []
synonym: "phosphocreatine biosynthesis" EXACT []
synonym: "phosphocreatine formation" EXACT []
synonym: "phosphocreatine synthesis" EXACT []
is_a: GO:0006603 ! phosphocreatine metabolic process
is_a: GO:0042396 ! phosphagen biosynthetic process

[Term]
id: GO:0046315
name: phosphocreatine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phosphocreatine, a phosphagen of creatine which is synthesized and broken down by creatine phosphokinase." [GOC:ai]
subset: gosubset_prok
synonym: "phosphocreatine breakdown" EXACT []
synonym: "phosphocreatine catabolism" EXACT []
synonym: "phosphocreatine degradation" EXACT []
is_a: GO:0006603 ! phosphocreatine metabolic process
is_a: GO:0042397 ! phosphagen catabolic process

[Term]
id: GO:0046316
name: gluconokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-gluconate + ATP = 6-phospho-D-gluconate + ADP + 2 H(+)." [EC:2.7.1.12, RHEA:19436]
subset: gosubset_prok
synonym: "ATP:D-gluconate 6-phosphotransferase activity" EXACT [EC:2.7.1.12]
synonym: "gluconate kinase activity" EXACT [EC:2.7.1.12]
synonym: "gluconokinase (phosphorylating)" EXACT [EC:2.7.1.12]
xref: EC:2.7.1.12
xref: KEGG:R01737
xref: MetaCyc:GLUCONOKIN-RXN
xref: RHEA:19436
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0046317
name: regulation of glucosylceramide biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosylceramide." [GOC:ai, GOC:ascb_2009, GOC:dph, GOC:tb]
subset: gosubset_prok
synonym: "regulation of glucosylceramide anabolism" EXACT []
synonym: "regulation of glucosylceramide biosynthesis" EXACT []
synonym: "regulation of glucosylceramide formation" EXACT []
synonym: "regulation of glucosylceramide synthesis" EXACT []
is_a: GO:2000303 ! regulation of ceramide biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006679 ! glucosylceramide biosynthetic process
relationship: regulates GO:0006679 ! glucosylceramide biosynthetic process

[Term]
id: GO:0046318
name: negative regulation of glucosylceramide biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosylceramide." [GOC:ai, GOC:ascb_2009, GOC:dph, GOC:tb]
subset: gosubset_prok
synonym: "down regulation of glucosylceramide biosynthetic process" EXACT []
synonym: "down-regulation of glucosylceramide biosynthetic process" EXACT []
synonym: "downregulation of glucosylceramide biosynthetic process" EXACT []
synonym: "inhibition of glucosylceramide biosynthetic process" NARROW []
synonym: "negative regulation of glucosylceramide anabolism" EXACT []
synonym: "negative regulation of glucosylceramide biosynthesis" EXACT []
synonym: "negative regulation of glucosylceramide formation" EXACT []
synonym: "negative regulation of glucosylceramide synthesis" EXACT []
is_a: GO:0046317 ! regulation of glucosylceramide biosynthetic process
is_a: GO:1900060 ! negative regulation of ceramide biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006679 ! glucosylceramide biosynthetic process
relationship: negatively_regulates GO:0006679 ! glucosylceramide biosynthetic process

[Term]
id: GO:0046319
name: positive regulation of glucosylceramide biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosylceramide." [GOC:ai]
subset: gosubset_prok
synonym: "activation of glucosylceramide biosynthetic process" NARROW []
synonym: "positive regulation of glucosylceramide anabolism" EXACT []
synonym: "positive regulation of glucosylceramide biosynthesis" EXACT []
synonym: "positive regulation of glucosylceramide formation" EXACT []
synonym: "positive regulation of glucosylceramide synthesis" EXACT []
synonym: "stimulation of glucosylceramide biosynthetic process" NARROW []
synonym: "up regulation of glucosylceramide biosynthetic process" EXACT []
synonym: "up-regulation of glucosylceramide biosynthetic process" EXACT []
synonym: "upregulation of glucosylceramide biosynthetic process" EXACT []
is_a: GO:0046317 ! regulation of glucosylceramide biosynthetic process
is_a: GO:2000304 ! positive regulation of ceramide biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006679 ! glucosylceramide biosynthetic process
relationship: positively_regulates GO:0006679 ! glucosylceramide biosynthetic process

[Term]
id: GO:0046320
name: regulation of fatty acid oxidation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fatty acid oxidation." [GOC:ai]
subset: gosubset_prok
xref: Reactome:REACT_102111 "Activated AMPK stimulates fatty-acid oxidation in muscle, Drosophila melanogaster"
xref: Reactome:REACT_104253 "Activated AMPK stimulates fatty-acid oxidation in muscle, Xenopus tropicalis"
xref: Reactome:REACT_108940 "Activated AMPK stimulates fatty-acid oxidation in muscle, Danio rerio"
xref: Reactome:REACT_110214 "Activated AMPK stimulates fatty-acid oxidation in muscle, Taeniopygia guttata"
xref: Reactome:REACT_110452 "Activated AMPK stimulates fatty-acid oxidation in muscle, Schizosaccharomyces pombe"
xref: Reactome:REACT_11163 "Activated AMPK stimulates fatty-acid oxidation in muscle, Homo sapiens"
xref: Reactome:REACT_114959 "Activated AMPK stimulates fatty-acid oxidation in muscle, Mycobacterium tuberculosis"
xref: Reactome:REACT_28747 "Activated AMPK stimulates fatty-acid oxidation in muscle, Canis familiaris"
xref: Reactome:REACT_30569 "Activated AMPK stimulates fatty-acid oxidation in muscle, Caenorhabditis elegans"
xref: Reactome:REACT_83314 "Activated AMPK stimulates fatty-acid oxidation in muscle, Gallus gallus"
xref: Reactome:REACT_84972 "Activated AMPK stimulates fatty-acid oxidation in muscle, Mus musculus"
xref: Reactome:REACT_86454 "Activated AMPK stimulates fatty-acid oxidation in muscle, Dictyostelium discoideum"
xref: Reactome:REACT_86534 "Activated AMPK stimulates fatty-acid oxidation in muscle, Bos taurus"
xref: Reactome:REACT_90327 "Activated AMPK stimulates fatty-acid oxidation in muscle, Rattus norvegicus"
xref: Reactome:REACT_90516 "Activated AMPK stimulates fatty-acid oxidation in muscle, Arabidopsis thaliana"
xref: Reactome:REACT_92705 "Activated AMPK stimulates fatty-acid oxidation in muscle, Sus scrofa"
xref: Reactome:REACT_94410 "Activated AMPK stimulates fatty-acid oxidation in muscle, Oryza sativa"
xref: Reactome:REACT_95569 "Activated AMPK stimulates fatty-acid oxidation in muscle, Saccharomyces cerevisiae"
is_a: GO:0019217 ! regulation of fatty acid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019395 ! fatty acid oxidation
relationship: regulates GO:0019395 ! fatty acid oxidation

[Term]
id: GO:0046321
name: positive regulation of fatty acid oxidation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of fatty acid oxidation." [GOC:ai]
subset: gosubset_prok
synonym: "activation of fatty acid oxidation" NARROW []
synonym: "stimulation of fatty acid oxidation" NARROW []
synonym: "up regulation of fatty acid oxidation" EXACT []
synonym: "up-regulation of fatty acid oxidation" EXACT []
synonym: "upregulation of fatty acid oxidation" EXACT []
is_a: GO:0045923 ! positive regulation of fatty acid metabolic process
is_a: GO:0046320 ! regulation of fatty acid oxidation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0019395 ! fatty acid oxidation
relationship: positively_regulates GO:0019395 ! fatty acid oxidation

[Term]
id: GO:0046322
name: negative regulation of fatty acid oxidation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid oxidation." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of fatty acid oxidation" EXACT []
synonym: "down-regulation of fatty acid oxidation" EXACT []
synonym: "downregulation of fatty acid oxidation" EXACT []
synonym: "inhibition of fatty acid oxidation" NARROW []
is_a: GO:0045922 ! negative regulation of fatty acid metabolic process
is_a: GO:0046320 ! regulation of fatty acid oxidation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019395 ! fatty acid oxidation
relationship: negatively_regulates GO:0019395 ! fatty acid oxidation

[Term]
id: GO:0046323
name: glucose import
namespace: biological_process
def: "The directed movement of the hexose monosaccharide glucose into a cell or organelle." [GOC:ai]
subset: gosubset_prok
synonym: "glucose uptake" EXACT [GOC:dph, GOC:tb]
xref: Wikipedia:Glucose_uptake
is_a: GO:0015758 ! glucose transport

[Term]
id: GO:0046324
name: regulation of glucose import
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle." [GOC:ai]
subset: gosubset_prok
synonym: "regulation of glucose uptake" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010827 ! regulation of glucose transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0046323 ! glucose import
relationship: regulates GO:0046323 ! glucose import

[Term]
id: GO:0046325
name: negative regulation of glucose import
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle." [GOC:ai]
synonym: "down regulation of glucose import" EXACT []
synonym: "down-regulation of glucose import" EXACT []
synonym: "downregulation of glucose import" EXACT []
synonym: "inhibition of glucose import" NARROW []
synonym: "negative regulation of glucose uptake" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010829 ! negative regulation of glucose transport
is_a: GO:0046324 ! regulation of glucose import
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0046323 ! glucose import
relationship: negatively_regulates GO:0046323 ! glucose import

[Term]
id: GO:0046326
name: positive regulation of glucose import
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle." [GOC:ai, GOC:dph, GOC:tb]
subset: gosubset_prok
synonym: "activation of glucose import" NARROW []
synonym: "positive regulation of glucose uptake" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of glucose import" NARROW []
synonym: "up regulation of glucose import" EXACT []
synonym: "up-regulation of glucose import" EXACT []
synonym: "upregulation of glucose import" EXACT []
is_a: GO:0010828 ! positive regulation of glucose transport
is_a: GO:0046324 ! regulation of glucose import
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0046323 ! glucose import
relationship: positively_regulates GO:0046323 ! glucose import

[Term]
id: GO:0046327
name: glycerol biosynthetic process from pyruvate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycerol, 1,2,3-propanetriol, from other compounds, including pyruvate." [GOC:ai]
subset: gosubset_prok
synonym: "glycerol anabolism from pyruvate" EXACT []
synonym: "glycerol formation from pyruvate" EXACT []
synonym: "glycerol synthesis from pyruvate" EXACT []
synonym: "glyceroneogenesis" EXACT []
is_a: GO:0006090 ! pyruvate metabolic process
is_a: GO:0006114 ! glycerol biosynthetic process
relationship: part_of GO:0019432 ! triglyceride biosynthetic process

[Term]
id: GO:0046328
name: regulation of JNK cascade
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf]
synonym: "regulation of SAPK cascade" BROAD []
is_a: GO:0032872 ! regulation of stress-activated MAPK cascade
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007254 ! JNK cascade
relationship: regulates GO:0007254 ! JNK cascade

[Term]
id: GO:0046329
name: negative regulation of JNK cascade
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf]
synonym: "down regulation of JNK cascade" EXACT []
synonym: "down-regulation of JNK cascade" EXACT []
synonym: "downregulation of JNK cascade" EXACT []
synonym: "inhibition of JNK cascade" NARROW []
is_a: GO:0032873 ! negative regulation of stress-activated MAPK cascade
is_a: GO:0046328 ! regulation of JNK cascade
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007254 ! JNK cascade
relationship: negatively_regulates GO:0007254 ! JNK cascade

[Term]
id: GO:0046330
name: positive regulation of JNK cascade
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf]
synonym: "activation of JNK cascade" NARROW []
synonym: "stimulation of JNK cascade" NARROW []
synonym: "up regulation of JNK cascade" EXACT []
synonym: "up-regulation of JNK cascade" EXACT []
synonym: "upregulation of JNK cascade" EXACT []
is_a: GO:0032874 ! positive regulation of stress-activated MAPK cascade
is_a: GO:0046328 ! regulation of JNK cascade
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007254 ! JNK cascade
relationship: positively_regulates GO:0007254 ! JNK cascade

[Term]
id: GO:0046331
name: lateral inhibition
namespace: biological_process
def: "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
is_a: GO:0045168 ! cell-cell signaling involved in cell fate commitment

[Term]
id: GO:0046332
name: SMAD binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a SMAD signaling protein." [GOC:ai]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0046333
name: octopamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol. The D enantiomer is about one-tenth as active as norepinephrine and is found in the salivary glands of Octopus and Eledone species." [ISBN:0198506732]
synonym: "octopamine metabolism" EXACT []
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0042133 ! neurotransmitter metabolic process
is_a: GO:0042439 ! ethanolamine-containing compound metabolic process
is_a: GO:0097164 ! ammonium ion metabolic process

[Term]
id: GO:0046334
name: octopamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol. The D enantiomer is about one-tenth as active as norepinephrine and is found in the salivary glands of Octopus and Eledone species." [ISBN:0198506732]
synonym: "octopamine breakdown" EXACT []
synonym: "octopamine catabolism" EXACT []
synonym: "octopamine degradation" EXACT []
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0042135 ! neurotransmitter catabolic process
is_a: GO:0042402 ! cellular biogenic amine catabolic process
is_a: GO:0046164 ! alcohol catabolic process
is_a: GO:0046333 ! octopamine metabolic process

[Term]
id: GO:0046335
name: ethanolamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine)." [GOC:ai]
subset: gosubset_prok
synonym: "ethanolamine anabolism" EXACT []
synonym: "ethanolamine biosynthesis" EXACT []
synonym: "ethanolamine formation" EXACT []
synonym: "ethanolamine synthesis" EXACT []
is_a: GO:0006580 ! ethanolamine metabolic process
is_a: GO:0034309 ! primary alcohol biosynthetic process
is_a: GO:0042401 ! cellular biogenic amine biosynthetic process
is_a: GO:1901162 ! primary amino compound biosynthetic process

[Term]
id: GO:0046336
name: ethanolamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine)." [GOC:ai]
subset: gosubset_prok
synonym: "ethanolamine breakdown" EXACT []
synonym: "ethanolamine catabolism" EXACT []
synonym: "ethanolamine degradation" EXACT []
is_a: GO:0006580 ! ethanolamine metabolic process
is_a: GO:0034310 ! primary alcohol catabolic process
is_a: GO:0042402 ! cellular biogenic amine catabolic process
is_a: GO:1901161 ! primary amino compound catabolic process

[Term]
id: GO:0046337
name: phosphatidylethanolamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. It is a major structural phospholipid in mammalian systems. It tends to be more abundant than phosphatidylcholine in the internal membranes of the cell and is an abundant component of prokaryotic membranes." [CHEBI:16038, GOC:curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "phosphatidylethanolamine metabolism" EXACT []
is_a: GO:0006650 ! glycerophospholipid metabolic process

[Term]
id: GO:0046338
name: phosphatidylethanolamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine." [ISBN:0198506732]
subset: gosubset_prok
synonym: "phosphatidylethanolamine breakdown" EXACT []
synonym: "phosphatidylethanolamine catabolism" EXACT []
synonym: "phosphatidylethanolamine degradation" EXACT []
is_a: GO:0046337 ! phosphatidylethanolamine metabolic process
is_a: GO:0046475 ! glycerophospholipid catabolic process

[Term]
id: GO:0046339
name: diacylglycerol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group." [CHEBI:18035, GOC:curators]
subset: gosubset_prok
synonym: "diacylglycerol metabolism" EXACT []
synonym: "diglyceride metabolism" EXACT []
is_a: GO:0006639 ! acylglycerol metabolic process

[Term]
id: GO:0046340
name: diacylglycerol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group." [CHEBI:18035, GOC:curators]
subset: gosubset_prok
synonym: "diacylglycerol breakdown" EXACT []
synonym: "diacylglycerol catabolism" EXACT []
synonym: "diacylglycerol degradation" EXACT []
synonym: "diglyceride catabolism" EXACT []
is_a: GO:0046339 ! diacylglycerol metabolic process
is_a: GO:0046464 ! acylglycerol catabolic process

[Term]
id: GO:0046341
name: CDP-diacylglycerol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate. It is a common intermediate in phospholipid biosynthesis." [CHEBI:17962, GOC:curators]
subset: gosubset_prok
synonym: "CDP-diacylglycerol metabolism" EXACT []
is_a: GO:0006650 ! glycerophospholipid metabolic process

[Term]
id: GO:0046342
name: CDP-diacylglycerol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate." [CHEBI:17962, GOC:curators]
subset: gosubset_prok
synonym: "CDP-diacylglycerol breakdown" EXACT []
synonym: "CDP-diacylglycerol catabolism" EXACT []
synonym: "CDP-diacylglycerol degradation" EXACT []
is_a: GO:0046341 ! CDP-diacylglycerol metabolic process
is_a: GO:0046475 ! glycerophospholipid catabolic process

[Term]
id: GO:0046343
name: streptomycin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving streptomycin, a commonly used antibiotic in cell culture media. It acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome." [CHEBI:17076, GOC:curators]
subset: gosubset_prok
synonym: "streptomycin metabolism" EXACT []
is_a: GO:0019751 ! polyol metabolic process
is_a: GO:0030647 ! aminoglycoside antibiotic metabolic process

[Term]
id: GO:0046344
name: ecdysteroid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development." [GOC:ai]
synonym: "ecdysteroid breakdown" EXACT []
synonym: "ecdysteroid catabolism" EXACT []
synonym: "ecdysteroid degradation" EXACT []
is_a: GO:0006706 ! steroid catabolic process
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:0042447 ! hormone catabolic process
is_a: GO:0045455 ! ecdysteroid metabolic process

[Term]
id: GO:0046345
name: abscisic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of abscisic acid, 5-(1-hydroxy-2,6,6,trimethyl-4-oxocyclohex-2-en-1-y1)-3-methylpenta-2,4-dienoic acid." [GOC:ai]
subset: gosubset_prok
synonym: "abscisic acid breakdown" EXACT []
synonym: "abscisic acid catabolism" EXACT []
synonym: "abscisic acid degradation" EXACT []
is_a: GO:0009687 ! abscisic acid metabolic process
is_a: GO:0016107 ! sesquiterpenoid catabolic process
is_a: GO:0043290 ! apocarotenoid catabolic process
is_a: GO:0046164 ! alcohol catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0046346
name: mannosamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of mannosomine, 2-amino-2-deoxymannose; the D-isomer is a constituent of neuraminic acids as well as mucolipids and mucoproteins." [CHEBI:25166, GOC:curators]
subset: gosubset_prok
synonym: "mannosamine breakdown" EXACT []
synonym: "mannosamine catabolism" EXACT []
synonym: "mannosamine degradation" EXACT []
is_a: GO:0006050 ! mannosamine metabolic process
is_a: GO:0046348 ! amino sugar catabolic process

[Term]
id: GO:0046347
name: mannosamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of mannosomine, 2-amino-2-deoxymannose; the D-isomer is a constituent of neuraminic acids as well as mucolipids and mucoproteins." [CHEBI:25166, GOC:curators]
subset: gosubset_prok
synonym: "mannosamine anabolism" EXACT []
synonym: "mannosamine biosynthesis" EXACT []
synonym: "mannosamine formation" EXACT []
synonym: "mannosamine synthesis" EXACT []
is_a: GO:0006050 ! mannosamine metabolic process
is_a: GO:0046349 ! amino sugar biosynthetic process

[Term]
id: GO:0046348
name: amino sugar catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any amino sugar, sugars containing an amino group in place of a hydroxyl group." [CHEBI:28963, GOC:curators]
subset: gosubset_prok
synonym: "amino sugar breakdown" EXACT []
synonym: "amino sugar catabolism" EXACT []
synonym: "amino sugar degradation" EXACT []
synonym: "aminosaccharide catabolic process" EXACT []
synonym: "aminosaccharide catabolism" EXACT []
is_a: GO:0006040 ! amino sugar metabolic process
is_a: GO:1901136 ! carbohydrate derivative catabolic process

[Term]
id: GO:0046349
name: amino sugar biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any amino sugar, sugars containing an amino group in place of a hydroxyl group." [CHEBI:28963, GOC:curators]
subset: gosubset_prok
synonym: "amino sugar anabolism" EXACT []
synonym: "amino sugar biosynthesis" EXACT []
synonym: "amino sugar formation" EXACT []
synonym: "amino sugar synthesis" EXACT []
synonym: "aminosaccharide biosynthesis" EXACT []
synonym: "aminosaccharide biosynthetic process" EXACT []
is_a: GO:0006040 ! amino sugar metabolic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process

[Term]
id: GO:0046350
name: galactosaminoglycan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving galactosaminoglycans, any one of a group of polysaccharides that contain amino sugars derived from the galactose." [GOC:ai]
subset: gosubset_prok
synonym: "galactosaminoglycan metabolism" EXACT []
is_a: GO:0030203 ! glycosaminoglycan metabolic process

[Term]
id: GO:0046351
name: disaccharide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of disaccharides, sugars composed of two monosaccharide units." [GOC:ai]
subset: gosubset_prok
synonym: "disaccharide anabolism" EXACT []
synonym: "disaccharide biosynthesis" EXACT []
synonym: "disaccharide formation" EXACT []
synonym: "disaccharide synthesis" EXACT []
is_a: GO:0005984 ! disaccharide metabolic process
is_a: GO:0009312 ! oligosaccharide biosynthetic process
is_a: GO:0034637 ! cellular carbohydrate biosynthetic process

[Term]
id: GO:0046352
name: disaccharide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of disaccharides, sugars composed of two monosaccharide units." [GOC:ai]
subset: gosubset_prok
synonym: "disaccharide breakdown" EXACT []
synonym: "disaccharide catabolism" EXACT []
synonym: "disaccharide degradation" EXACT []
is_a: GO:0005984 ! disaccharide metabolic process
is_a: GO:0009313 ! oligosaccharide catabolic process
is_a: GO:0044275 ! cellular carbohydrate catabolic process

[Term]
id: GO:0046353
name: aminoglycoside 3-N-acetyltransferase activity
namespace: molecular_function
alt_id: GO:0016991
def: "Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + 3-N-acetylaminoglycoside. This is acetylation of the 3-amino group of the central deoxystreptamine ring." [GOC:cb]
subset: gosubset_prok
synonym: "3'-aminoglycoside acetyltransferase activity" RELATED [EC:2.3.1.81]
synonym: "3-N-aminoglycoside acetyltransferase activity" EXACT [EC:2.3.1.81]
synonym: "acetyl-CoA:2-deoxystreptamine-antibiotic N3'-acetyltransferase activity" EXACT [EC:2.3.1.81]
synonym: "acetyl-CoA:gentamicin-C N3'-acetyltransferase activity" NARROW [EC:2.3.1.60]
synonym: "aminoglycoside acetyltransferase AAC(3)-1" RELATED [EC:2.3.1.60]
synonym: "aminoglycoside acetyltransferase AAC(3)-I activity" RELATED [EC:2.3.1.60]
synonym: "gentamicin 3'-N-acetyltransferase activity" NARROW []
synonym: "gentamicin acetyltransferase I activity" NARROW [EC:2.3.1.60]
synonym: "gentamicin-(3)-N-acetyltransferase activity" NARROW [EC:2.3.1.81]
synonym: "gentamycin 3'-N-acetyltransferase activity" EXACT []
synonym: "gentamycin acetyltransferase I" RELATED [EC:2.3.1.60]
xref: EC:2.3.1.60
xref: EC:2.3.1.81
xref: MetaCyc:AMINOGLYCOSIDE-N3-ACETYLTRANSFERASE-RXN
xref: MetaCyc:GENTAMICIN-3-N-ACETYLTRANSFERASE-RXN
is_a: GO:0034069 ! aminoglycoside N-acetyltransferase activity

[Term]
id: GO:0046354
name: mannan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of mannan, the main hemicellulose of soft (coniferous) wood, made up of D-mannose, D-glucose and D-galactose." [ISBN:0198506732]
subset: gosubset_prok
synonym: "mannan anabolism" EXACT []
synonym: "mannan biosynthesis" EXACT []
synonym: "mannan formation" EXACT []
synonym: "mannan synthesis" EXACT []
is_a: GO:0010412 ! mannan metabolic process
is_a: GO:0033692 ! cellular polysaccharide biosynthetic process

[Term]
id: GO:0046355
name: mannan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of mannan, the main hemicellulose of soft (coniferous) wood, made up of D-mannose, D-glucose and D-galactose." [ISBN:0198506732]
subset: gosubset_prok
synonym: "mannan breakdown" EXACT []
synonym: "mannan catabolism" EXACT []
synonym: "mannan degradation" EXACT []
is_a: GO:0010412 ! mannan metabolic process
is_a: GO:0016998 ! cell wall macromolecule catabolic process
is_a: GO:0044247 ! cellular polysaccharide catabolic process

[Term]
id: GO:0046356
name: acetyl-CoA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated." [GOC:ai]
subset: gosubset_prok
synonym: "acetyl-CoA breakdown" EXACT []
synonym: "acetyl-CoA catabolism" EXACT []
synonym: "acetyl-CoA degradation" EXACT []
is_a: GO:0006084 ! acetyl-CoA metabolic process
is_a: GO:0009109 ! coenzyme catabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:1901575 ! organic substance catabolic process

[Term]
id: GO:0046357
name: galactarate biosynthetic process
namespace: biological_process
alt_id: GO:0042872
def: "The chemical reactions and pathways resulting in the formation of galactarate, the anion of galactaric acid." [GOC:pr, ISBN:0198506732]
subset: gosubset_prok
synonym: "D-galactarate anabolism" RELATED []
synonym: "D-galactarate biosynthesis" RELATED []
synonym: "D-galactarate biosynthetic process" RELATED []
synonym: "D-galactarate formation" RELATED []
synonym: "D-galactarate synthesis" RELATED []
synonym: "galactarate anabolism" EXACT []
synonym: "galactarate biosynthesis" EXACT []
synonym: "galactarate formation" EXACT []
synonym: "galactarate synthesis" EXACT []
is_a: GO:0019578 ! aldaric acid biosynthetic process
is_a: GO:0019580 ! galactarate metabolic process

[Term]
id: GO:0046358
name: butyrate biosynthetic process
namespace: biological_process
alt_id: GO:0043439
def: "The chemical reactions and pathways resulting in the formation of butyrate, the anion of butyric acid." [ISBN:0198506732]
subset: gosubset_prok
synonym: "butanoic acid anabolism" EXACT []
synonym: "butanoic acid biosynthesis" EXACT []
synonym: "butanoic acid biosynthetic process" EXACT []
synonym: "butanoic acid formation" EXACT []
synonym: "butanoic acid synthesis" EXACT []
synonym: "butyrate anabolism" EXACT []
synonym: "butyrate biosynthesis" EXACT []
synonym: "butyrate formation" EXACT []
synonym: "butyrate synthesis" EXACT []
is_a: GO:0019605 ! butyrate metabolic process
is_a: GO:0051790 ! short-chain fatty acid biosynthetic process

[Term]
id: GO:0046359
name: butyrate catabolic process
namespace: biological_process
alt_id: GO:0043440
def: "The chemical reactions and pathways resulting in the breakdown of butyrate, the anion of butyric acid." [ISBN:0198506732]
subset: gosubset_prok
synonym: "butanoic acid breakdown" EXACT []
synonym: "butanoic acid catabolic process" EXACT []
synonym: "butanoic acid catabolism" EXACT []
synonym: "butanoic acid degradation" EXACT []
synonym: "butyrate breakdown" EXACT []
synonym: "butyrate catabolism" EXACT []
synonym: "butyrate degradation" EXACT []
is_a: GO:0019605 ! butyrate metabolic process
is_a: GO:0019626 ! short-chain fatty acid catabolic process

[Term]
id: GO:0046360
name: 2-oxobutyrate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 2-oxobutyrate, the anion of the organic acid 2-oxobutyric acid, which contains a ketone group on carbon 2." [ISBN:0198506732]
subset: gosubset_prok
synonym: "2-oxobutyrate anabolism" EXACT []
synonym: "2-oxobutyrate biosynthesis" EXACT []
synonym: "2-oxobutyrate formation" EXACT []
synonym: "2-oxobutyrate synthesis" EXACT []
synonym: "alpha-ketobutyrate biosynthesis" EXACT []
synonym: "alpha-ketobutyrate biosynthetic process" EXACT []
is_a: GO:0046361 ! 2-oxobutyrate metabolic process
is_a: GO:0051790 ! short-chain fatty acid biosynthetic process

[Term]
id: GO:0046361
name: 2-oxobutyrate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 2-oxobutyrate, the anion of the organic acid 2-oxobutyric acid, which contains a ketone group on carbon 2." [http://chemfinder.cambridgesoft.com/, ISBN:0198506732]
subset: gosubset_prok
synonym: "2-oxobutyrate metabolism" EXACT []
synonym: "alpha-ketobutyrate metabolic process" EXACT []
synonym: "alpha-ketobutyrate metabolism" EXACT []
is_a: GO:0046459 ! short-chain fatty acid metabolic process

[Term]
id: GO:0046362
name: ribitol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ribitol, a pentitol derived formally by reduction of the -CHO group of either D- or L-ribose." [ISBN:0198506732]
subset: gosubset_prok
synonym: "ribitol anabolism" EXACT []
synonym: "ribitol biosynthesis" EXACT []
synonym: "ribitol formation" EXACT []
synonym: "ribitol synthesis" EXACT []
is_a: GO:0019349 ! ribitol metabolic process
is_a: GO:0019526 ! pentitol biosynthetic process

[Term]
id: GO:0046363
name: ribitol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ribitol, a pentitol derived formally by reduction of the -CHO group of either D- or L-ribose." [ISBN:0198506732]
subset: gosubset_prok
synonym: "ribitol breakdown" EXACT []
synonym: "ribitol catabolism" EXACT []
synonym: "ribitol degradation" EXACT []
is_a: GO:0019349 ! ribitol metabolic process
is_a: GO:0019527 ! pentitol catabolic process

[Term]
id: GO:0046364
name: monosaccharide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms." [ISBN:0198506732]
subset: gosubset_prok
synonym: "monosaccharide anabolism" EXACT []
synonym: "monosaccharide biosynthesis" EXACT []
synonym: "monosaccharide formation" EXACT []
synonym: "monosaccharide synthesis" EXACT []
is_a: GO:0005996 ! monosaccharide metabolic process
is_a: GO:0016051 ! carbohydrate biosynthetic process
is_a: GO:0044283 ! small molecule biosynthetic process

[Term]
id: GO:0046365
name: monosaccharide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms." [ISBN:0198506732]
subset: gosubset_prok
synonym: "monosaccharide breakdown" EXACT []
synonym: "monosaccharide catabolism" EXACT []
synonym: "monosaccharide degradation" EXACT []
is_a: GO:0005996 ! monosaccharide metabolic process
is_a: GO:0044282 ! small molecule catabolic process
is_a: GO:0044724 ! single-organism carbohydrate catabolic process

[Term]
id: GO:0046366
name: allose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of allose, allo-hexose, an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3." [ISBN:0198506732]
subset: gosubset_prok
synonym: "allose anabolism" EXACT []
synonym: "allose biosynthesis" EXACT []
synonym: "allose formation" EXACT []
synonym: "allose synthesis" EXACT []
is_a: GO:0019313 ! allose metabolic process
is_a: GO:0019319 ! hexose biosynthetic process

[Term]
id: GO:0046367
name: allose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of allose, allo-hexose, an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3." [ISBN:0198506732]
subset: gosubset_prok
synonym: "allose breakdown" EXACT []
synonym: "allose catabolism" EXACT []
synonym: "allose degradation" EXACT []
is_a: GO:0019313 ! allose metabolic process
is_a: GO:0019320 ! hexose catabolic process

[Term]
id: GO:0046368
name: GDP-L-fucose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving GDP-L-fucose, a substance composed of L-fucose in glycosidic linkage with guanosine diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "GDP-L-fucose metabolism" EXACT []
is_a: GO:0009225 ! nucleotide-sugar metabolic process

[Term]
id: GO:0046369
name: galactose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of galactose, the aldohexose galacto-hexose." [ISBN:0198506732]
subset: gosubset_prok
synonym: "galactose anabolism" EXACT []
synonym: "galactose biosynthesis" EXACT []
synonym: "galactose formation" EXACT []
synonym: "galactose synthesis" EXACT []
is_a: GO:0006012 ! galactose metabolic process
is_a: GO:0019319 ! hexose biosynthetic process

[Term]
id: GO:0046370
name: fructose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of fructose, the ketohexose arabino-2-hexulose." [GOC:ai]
subset: gosubset_prok
synonym: "fructose anabolism" EXACT []
synonym: "fructose biosynthesis" EXACT []
synonym: "fructose formation" EXACT []
synonym: "fructose synthesis" EXACT []
is_a: GO:0006000 ! fructose metabolic process
is_a: GO:0019319 ! hexose biosynthetic process

[Term]
id: GO:0046371
name: dTDP-mannose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dTDP-mannose, a substance composed of mannose in glycosidic linkage with deoxyribosylthymine diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "dTDP-mannose metabolism" EXACT []
is_a: GO:0009225 ! nucleotide-sugar metabolic process

[Term]
id: GO:0046372
name: D-arabinose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-arabinose, the D-enantiomer of arabino-pentose. D-arabinose occurs in plant glycosides and is a constituent of arabinonucleosides." [CHEBI:17108, GOC:jsg, GOC:mah, ISBN:0198506732]
subset: gosubset_prok
synonym: "D-arabinose metabolism" EXACT []
is_a: GO:0019566 ! arabinose metabolic process

[Term]
id: GO:0046373
name: L-arabinose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving L-arabinose, the D-enantiomer of arabino-pentose. L-arabinose occurs free, e.g. in the heartwood of many conifers, and in the combined state, in both furanose and pyranose forms, as a constituent of various plant hemicelluloses, bacterial polysaccharides etc." [CHEBI:30849, GOC:jsg, GOC:mah, ISBN:0198506732]
subset: gosubset_prok
synonym: "L-arabinose metabolism" EXACT []
is_a: GO:0019566 ! arabinose metabolic process

[Term]
id: GO:0046374
name: teichoic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving teichoic acid, any polymer occurring in the cell wall, membrane or capsule of Gram-positive bacteria and containing chains of glycerol phosphate or ribitol phosphate residues." [ISBN:0198506732]
subset: gosubset_prok
synonym: "teichoic acid metabolism" EXACT []
is_a: GO:0043170 ! macromolecule metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:0046375
name: K antigen metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving K antigen, a capsular polysaccharide antigen carried on the surface of bacterial capsules that masks somatic (O) antigens." [ISBN:0198506732]
subset: gosubset_prok
synonym: "K antigen metabolism" EXACT []
is_a: GO:0044264 ! cellular polysaccharide metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:0046376
name: GDP-alpha-D-mannosylchitobiosyldiphosphodolichol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving GDP-alpha-D-mannosylchitobiosyldiphosphodolichol, a substance composed of mannosylchitobiosyldiphosphodolichol in glycosidic linkage with guanosine diphosphate." [ISBN:0198506732]
synonym: "GDP-alpha-D-mannosylchitobiosyldiphosphodolichol metabolism" EXACT []
is_a: GO:0006644 ! phospholipid metabolic process
is_a: GO:0006664 ! glycolipid metabolic process
is_a: GO:0006721 ! terpenoid metabolic process
is_a: GO:0009117 ! nucleotide metabolic process

[Term]
id: GO:0046377
name: colanic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving colanic acid, a capsular bacterial polysaccharide composed of glucose, galactose, fucose and glucuronic acid residues." [GOC:ai, http://www.science.siu.edu/microbiology/micr425/425Notes/02-CellEnv.html]
subset: gosubset_prok
synonym: "colanic acid metabolism" EXACT []
is_a: GO:0044264 ! cellular polysaccharide metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:0046378
name: enterobacterial common antigen metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving enterobacterial common antigen, an acidic polysaccharide containing N-acetyl-D-glucosamine, N-acetyl-D-mannosaminouronic acid, and 4-acetamido-4,6-dideoxy-D-galactose. A major component of the cell wall outer membrane of Gram-negative bacteria." [GOC:ma]
subset: gosubset_prok
synonym: "enterobacterial common antigen metabolism" EXACT []
is_a: GO:0044264 ! cellular polysaccharide metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:0046379
name: extracellular polysaccharide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving polysaccharides used in extracellular structures." [GOC:ai]
subset: gosubset_prok
synonym: "extracellular polysaccharide metabolism" EXACT []
is_a: GO:0044264 ! cellular polysaccharide metabolic process

[Term]
id: GO:0046380
name: N-acetylneuraminate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of N-acetylneuraminate, the anion of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid." [ISBN:0198506732]
subset: gosubset_prok
synonym: "N-acetylneuraminate anabolism" EXACT []
synonym: "N-acetylneuraminate biosynthesis" EXACT []
synonym: "N-acetylneuraminate formation" EXACT []
synonym: "N-acetylneuraminate synthesis" EXACT []
is_a: GO:0006054 ! N-acetylneuraminate metabolic process
is_a: GO:0046349 ! amino sugar biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process

[Term]
id: GO:0046381
name: CMP-N-acetylneuraminate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving CMP-N-acetylneuraminate, a substance composed of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid in glycosidic linkage with cytidine monophosphate." [GOC:ai]
subset: gosubset_prok
synonym: "CMP-N-acetylneuraminate metabolism" EXACT []
is_a: GO:0009225 ! nucleotide-sugar metabolic process

[Term]
id: GO:0046382
name: GDP-D-rhamnose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving GDP-D-rhamnose, a substance composed of rhamnose in glycosidic linkage with guanosine diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "GDP-D-rhamnose metabolism" EXACT []
is_a: GO:0009225 ! nucleotide-sugar metabolic process

[Term]
id: GO:0046383
name: dTDP-rhamnose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dTDP-rhamnose, a substance composed of rhamnose in glycosidic linkage with deoxyribosylthymine diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "dTDP-rhamnose metabolism" EXACT []
is_a: GO:0009225 ! nucleotide-sugar metabolic process

[Term]
id: GO:0046384
name: 2-deoxyribose 1-phosphate metabolic process
namespace: biological_process
alt_id: GO:0046388
def: "The chemical reactions and pathways involving 2-deoxyribose 1-phosphate, the phosphorylated sugar 1-phospho-2-deoxyribose." [ISBN:0198506732]
subset: gosubset_prok
synonym: "2-deoxyribose 1-phosphate metabolism" EXACT []
synonym: "deoxyribose 1-phosphate metabolic process" EXACT []
synonym: "deoxyribose 1-phosphate metabolism" EXACT []
is_a: GO:0019692 ! deoxyribose phosphate metabolic process

[Term]
id: GO:0046385
name: deoxyribose phosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose." [ISBN:0198506732]
subset: gosubset_prok
synonym: "deoxyribose phosphate anabolism" EXACT []
synonym: "deoxyribose phosphate biosynthesis" EXACT []
synonym: "deoxyribose phosphate formation" EXACT []
synonym: "deoxyribose phosphate synthesis" EXACT []
is_a: GO:0019692 ! deoxyribose phosphate metabolic process
is_a: GO:0090407 ! organophosphate biosynthetic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process

[Term]
id: GO:0046386
name: deoxyribose phosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose." [ISBN:0198506732]
subset: gosubset_prok
synonym: "deoxyribose phosphate breakdown" EXACT []
synonym: "deoxyribose phosphate catabolism" EXACT []
synonym: "deoxyribose phosphate degradation" EXACT []
is_a: GO:0019692 ! deoxyribose phosphate metabolic process
is_a: GO:0046434 ! organophosphate catabolic process
is_a: GO:1901136 ! carbohydrate derivative catabolic process

[Term]
id: GO:0046387
name: deoxyribose 1,5-bisphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving deoxyribose 1,5-bisphosphate, the diphosphorylated sugar 1,5-diphospho-2-deoxyribose." [GOC:ai]
subset: gosubset_prok
synonym: "deoxyribose 1,5-bisphosphate metabolism" EXACT []
is_a: GO:0019692 ! deoxyribose phosphate metabolic process

[Term]
id: GO:0046389
name: deoxyribose 5-phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving deoxyribose 5-phosphate, the phosphorylated sugar 5-phospho-2-deoxyribose." [GOC:ai]
subset: gosubset_prok
synonym: "deoxyribose 5-phosphate metabolism" EXACT []
is_a: GO:0019692 ! deoxyribose phosphate metabolic process

[Term]
id: GO:0046390
name: ribose phosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ribose phosphate, any phosphorylated ribose sugar." [GOC:ai]
subset: gosubset_prok
synonym: "ribose phosphate anabolism" EXACT []
synonym: "ribose phosphate biosynthesis" EXACT []
synonym: "ribose phosphate formation" EXACT []
synonym: "ribose phosphate synthesis" EXACT []
is_a: GO:0019693 ! ribose phosphate metabolic process
is_a: GO:0090407 ! organophosphate biosynthetic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process

[Term]
id: GO:0046391
name: 5-phosphoribose 1-diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 5-phosphoribose 1-diphosphate, also known as 5-phosphoribosyl-1-pyrophosphate." [GOC:ai]
subset: gosubset_prok
synonym: "5-phosphoribose 1-diphosphate metabolism" EXACT []
synonym: "PRPP metabolic process" EXACT []
xref: MetaCyc:PRPP-PWY
is_a: GO:0019693 ! ribose phosphate metabolic process

[Term]
id: GO:0046392
name: galactarate catabolic process
namespace: biological_process
alt_id: GO:0019582
def: "The chemical reactions and pathways resulting in the breakdown of galactarate, the anion of galactaric acid." [GOC:ai, GOC:pr]
subset: gosubset_prok
synonym: "D-galactarate breakdown" RELATED []
synonym: "D-galactarate catabolic process" RELATED []
synonym: "D-galactarate catabolism" RELATED []
synonym: "D-galactarate degradation" RELATED []
synonym: "galactarate breakdown" EXACT []
synonym: "galactarate catabolism" EXACT []
synonym: "galactarate degradation" EXACT []
xref: MetaCyc:GALACTARDEG-PWY
is_a: GO:0019579 ! aldaric acid catabolic process
is_a: GO:0019580 ! galactarate metabolic process

[Term]
id: GO:0046394
name: carboxylic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups." [ISBN:0198506732]
subset: gosubset_prok
synonym: "carboxylic acid anabolism" EXACT []
synonym: "carboxylic acid biosynthesis" EXACT []
synonym: "carboxylic acid formation" EXACT []
synonym: "carboxylic acid synthesis" EXACT []
is_a: GO:0016053 ! organic acid biosynthetic process
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0046395
name: carboxylic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups." [ISBN:0198506732]
subset: gosubset_prok
synonym: "carboxylic acid breakdown" EXACT []
synonym: "carboxylic acid catabolism" EXACT []
synonym: "carboxylic acid degradation" EXACT []
is_a: GO:0016054 ! organic acid catabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0046396
name: D-galacturonate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-galacturonate, the D-enantiomer of galacturonate, the anion of galacturonic acid. D-galacturonic acid is a component of plant gums and bacterial cell walls." [GOC:ai, GOC:jsg, GOC:mah, ISBN:0198506732]
subset: gosubset_prok
synonym: "D-galacturonate metabolism" EXACT []
is_a: GO:0019586 ! galacturonate metabolic process

[Term]
id: GO:0046397
name: galacturonate catabolic process
namespace: biological_process
alt_id: GO:0019587
def: "The chemical reactions and pathways resulting in the breakdown of galacturonate, the anion of galacturonic acid." [GOC:ai]
subset: gosubset_prok
synonym: "galacturonate breakdown" EXACT []
synonym: "galacturonate catabolism" EXACT []
synonym: "galacturonate degradation" EXACT []
is_a: GO:0019586 ! galacturonate metabolic process
is_a: GO:0046365 ! monosaccharide catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process

[Term]
id: GO:0046398
name: UDP-glucuronate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving UDP-glucuronate, a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "UDP-glucuronate metabolism" EXACT []
is_a: GO:0009225 ! nucleotide-sugar metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0046399
name: glucuronate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glucuronate, the anion of glucuronic acid." [GOC:ai]
subset: gosubset_prok
synonym: "glucuronate anabolism" EXACT []
synonym: "glucuronate biosynthesis" EXACT []
synonym: "glucuronate formation" EXACT []
synonym: "glucuronate synthesis" EXACT []
is_a: GO:0019585 ! glucuronate metabolic process
is_a: GO:0046364 ! monosaccharide biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process

[Term]
id: GO:0046400
name: keto-3-deoxy-D-manno-octulosonic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving keto-3-deoxy-D-manno-octulosonic acid, an acidic sugar present in lipopolysaccharides of the outer membranes of some Gram-negative bacteria." [CHEBI:32817, GOC:ai, ISBN:0198506732]
subset: gosubset_prok
synonym: "KDO metabolic process" EXACT [GOC:mah]
synonym: "KDO metabolism" EXACT [GOC:mah]
synonym: "keto-3-deoxy-D-manno-octulosonic acid metabolism" EXACT []
synonym: "ketodeoxyoctanoate metabolic process" RELATED [ISBN:0198506732]
is_a: GO:0005996 ! monosaccharide metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0046401
name: lipopolysaccharide core region metabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the core region of bacterial lipopolysaccharides, which contains ten saccharide residues. The structure of this core oligosaccharide appears to be similar in closely related bacterial strains." [ISBN:0198506732]
subset: gosubset_prok
synonym: "lipopolysaccharide core region metabolism" EXACT []
synonym: "LPS core region metabolic process" EXACT []
is_a: GO:0009311 ! oligosaccharide metabolic process
relationship: part_of GO:0008653 ! lipopolysaccharide metabolic process

[Term]
id: GO:0046402
name: O antigen metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the O side chain of a lipopolysaccharide, which determines the antigenic specificity of the organism. It is made up of about 50 repeating units of a branched tetrasaccharide." [ISBN:0198506732]
subset: gosubset_prok
synonym: "O antigen metabolism" EXACT []
is_a: GO:0044264 ! cellular polysaccharide metabolic process

[Term]
id: GO:0046403
name: polynucleotide 3'-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphopolynucleotide + H2O = a polynucleotide + phosphate. Hydrolyzes the free 3'-phosphate resulting from single strand breaks in DNA due to oxidative damage." [EC:3.1.3.32]
synonym: "2'(3')-polynucleotidase activity" EXACT [EC:3.1.3.32]
synonym: "5'-polynucleotidekinase 3'-phosphatase activity" EXACT [EC:3.1.3.32]
synonym: "deoxyribonucleate 3'-phosphatase activity" EXACT [EC:3.1.3.32]
synonym: "DNA 3'-phosphatase activity" EXACT [EC:3.1.3.32]
synonym: "polynucleotide 3'-phosphohydrolase activity" EXACT [EC:3.1.3.32]
xref: EC:3.1.3.32
xref: MetaCyc:POLYNUCLEOTIDE-3-PHOSPHATASE-RXN
is_a: GO:0098518 ! polynucleotide phosphatase activity
relationship: part_of GO:0098506 ! polynucleotide 3' dephosphorylation

[Term]
id: GO:0046404
name: ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 5'-dephospho-DNA = ADP + 5'-phospho-DNA." [EC:2.7.1.78]
synonym: "ATP-dependent DNA 5'-hydroxyl-kinase activity" EXACT []
synonym: "ATP-dependent DNA kinase activity" EXACT []
synonym: "ATP-dependent polynucleotide 5'-hydroxyl-kinase activity" BROAD []
synonym: "ATP:5'-dephosphopolydeoxyribonucleotide 5'-phosphotransferase activity" EXACT []
xref: EC:2.7.1.78
xref: KEGG:R03840
xref: MetaCyc:POLYNUCLEOTIDE-5-HYDROXYL-KINASE-RXN
is_a: GO:0051733 ! polydeoxyribonucleotide kinase activity
is_a: GO:0051734 ! ATP-dependent polynucleotide kinase activity

[Term]
id: GO:0046405
name: glycerol dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycerol = 3-hydroxypropanal + H2O." [EC:4.2.1.30, PMID:18307109]
subset: gosubset_prok
synonym: "glycerol dehydrase activity" EXACT [EC:4.2.1.30]
synonym: "glycerol hydro-lyase (3-hydroxypropanal-forming)" EXACT [EC:4.2.1.30]
synonym: "glycerol hydro-lyase activity" EXACT [EC:4.2.1.30]
xref: EC:4.2.1.30
xref: MetaCyc:GLYCEROL-DEHYDRATASE-RXN
xref: RHEA:19768
is_a: GO:0016836 ! hydro-lyase activity
is_a: GO:0070283 ! radical SAM enzyme activity

[Term]
id: GO:0046406
name: magnesium protoporphyrin IX methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + magnesium protoporphyrin IX = S-adenosyl-L-homocysteine + H(+) + magnesium protoporphyrin IX 13-monomethyl ester." [EC:2.1.1.11, RHEA:17812]
subset: gosubset_prok
synonym: "(-)-S-adenosyl-L-methionine:magnesium-protoporphyrin IX methyltransferase activity" EXACT [EC:2.1.1.11]
synonym: "magnesium-protoporphyrin O-methyltransferase activity" EXACT []
synonym: "Mg-protoporphyrin IX methyltransferase activity" EXACT [EC:2.1.1.11]
synonym: "S-adenosyl-L-methionine:magnesium-protoporphyrin O-methyltransferase activity" EXACT [EC:2.1.1.11]
synonym: "S-adenosyl-L-methionine:magnesium-protoporphyrin-IX O-methyltransferase activity" EXACT [EC:2.1.1.11]
synonym: "S-adenosyl-L-methionine:Mg protoporphyrin methyltransferase activity" EXACT [EC:2.1.1.11]
synonym: "S-adenosylmethionine-magnesium protoporphyrin methyltransferase activity" EXACT [EC:2.1.1.11]
synonym: "S-adenosylmethioninemagnesium protoporphyrin methyltransferase activity" EXACT [EC:2.1.1.11]
xref: EC:2.1.1.11
xref: KEGG:R04237
xref: MetaCyc:RXN-MG-PROTOPORPHYRIN-METHYLESTER-SYN
xref: RHEA:17812
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0046408
name: chlorophyll synthetase activity
namespace: molecular_function
alt_id: GO:0043787
def: "Catalysis of the reaction: chlorophyllide a + 2 H(+) + phytyl diphosphate = chlorophyll a + diphosphate." [EC:2.5.1.62, RHEA:17320]
synonym: "chlorophyll synthase activity" EXACT []
synonym: "chlorophyllide-a:phytyl-diphosphate phytyltransferase activity" EXACT []
xref: EC:2.5.1.62
xref: KEGG:R06284
xref: MetaCyc:RXN1F-66
xref: RHEA:17320
is_a: GO:0004659 ! prenyltransferase activity

[Term]
id: GO:0046409
name: p-coumarate 3-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: shikimate or quinate ester of p-coumaric acid + NADPH + H+ + O2 = caffeic acid conjugate (caffeoyl shikimic acid or chlorogenic acid) + H2O + NADP+." [PMID:11429408, PMID:11891223]
synonym: "cytochrome P450 CYP98A3" NARROW []
is_a: GO:0004497 ! monooxygenase activity

[Term]
id: GO:0046410
name: obsolete 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-oxoglutarate + isochorismate = 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate + pyruvate + CO2." [EC:2.5.1.64, PMID:1459959]
comment: This term was made obsolete because it was derived from an EC entry (2.5.1.64) that has since been split into two entries.
synonym: "2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity" EXACT []
is_obsolete: true
consider: GO:0070204
consider: GO:0070205

[Term]
id: GO:0046411
name: 2-keto-3-deoxygluconate transport
namespace: biological_process
def: "The directed movement of 2-keto-3-deoxygluconate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore by means of some agent such as a transporter or pore." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0015749 ! monosaccharide transport
is_a: GO:0042873 ! aldonate transport

[Term]
id: GO:0046412
name: phenylmercury acetate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phenylmercury acetate, an organomercurial compound composed of a mercury atom attached to a benzene ring and an acetate group." [GOC:ai]
subset: gosubset_prok
synonym: "phenylmercury acetate metabolism" EXACT []
is_a: GO:0018941 ! organomercury metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:0046413
name: organomercury catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of organomercury compounds, any organic compound containing a mercury atom." [GOC:ai]
subset: gosubset_prok
synonym: "organomercury breakdown" EXACT []
synonym: "organomercury catabolism" EXACT []
synonym: "organomercury degradation" EXACT []
is_a: GO:0018941 ! organomercury metabolic process
is_a: GO:0044248 ! cellular catabolic process
is_a: GO:1901575 ! organic substance catabolic process

[Term]
id: GO:0046414
name: organomercury biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of organomercury compounds, any organic compound containing a mercury atom." [GOC:ai]
subset: gosubset_prok
synonym: "organomercury anabolism" EXACT []
synonym: "organomercury biosynthesis" EXACT []
synonym: "organomercury formation" EXACT []
synonym: "organomercury synthesis" EXACT []
is_a: GO:0018941 ! organomercury metabolic process
is_a: GO:0044249 ! cellular biosynthetic process
is_a: GO:1901576 ! organic substance biosynthetic process

[Term]
id: GO:0046415
name: urate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving urate, the anion of uric acid, 2,6,8-trioxypurine, the end product of purine metabolism in certain mammals and the main excretory product in uricotelic animals." [ISBN:0198506732]
subset: gosubset_prok
synonym: "urate metabolism" EXACT []
is_a: GO:0006082 ! organic acid metabolic process
is_a: GO:0072521 ! purine-containing compound metabolic process

[Term]
id: GO:0046416
name: D-amino acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-amino acids, the D-enantiomers of amino acids." [GOC:ai, GOC:jsg]
subset: gosubset_prok
synonym: "D-amino acid metabolism" EXACT []
is_a: GO:1901605 ! alpha-amino acid metabolic process

[Term]
id: GO:0046417
name: chorismate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving chorismate, the anion of (3R-trans)-3-((1-carboxyethenyl)oxy)-4-hydroxy-1,5-cyclohexadiene-1-carboxylic acid." [ISBN:0198506732]
subset: gosubset_prok
synonym: "chorismate metabolism" EXACT []
is_a: GO:0043648 ! dicarboxylic acid metabolic process

[Term]
id: GO:0046418
name: nopaline metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nopaline, (N-(I-carboxy-4-guanidinobutyl)glutamic acid), a rare amino-acid derivative." [GOC:ai]
subset: gosubset_prok
synonym: "nopaline metabolism" EXACT []
is_a: GO:0006575 ! cellular modified amino acid metabolic process
is_a: GO:0072350 ! tricarboxylic acid metabolic process
is_a: GO:1901605 ! alpha-amino acid metabolic process

[Term]
id: GO:0046419
name: octopine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving octopine, (N-(1-carboxy-4-guanidinobutyl)-L-alanine), an amino acid derived opine." [GOC:ai]
subset: gosubset_prok
synonym: "octopine metabolism" EXACT []
is_a: GO:0006575 ! cellular modified amino acid metabolic process
is_a: GO:0043648 ! dicarboxylic acid metabolic process
is_a: GO:0046416 ! D-amino acid metabolic process

[Term]
id: GO:0046421
name: methylisocitrate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate." [EC:4.1.3.30, RHEA:16812]
subset: gosubset_prok
synonym: "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase (succinate-forming)" EXACT [EC:4.1.3.30]
synonym: "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase activity" EXACT [EC:4.1.3.30]
synonym: "2-methylisocitrate lyase activity" EXACT []
synonym: "MICL" RELATED [EC:4.1.3.30]
xref: EC:4.1.3.30
xref: KEGG:R00409
xref: MetaCyc:METHYLISOCITRATE-LYASE-RXN
xref: RHEA:16812
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0046422
name: violaxanthin de-epoxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: violaxanthin + 2 ascorbate = zeaxanthin + 2 dehydroascorbate + 2 H2O; and antheraxanthin + ascorbate = zeaxanthin + dehydroascorbate + H2O." [EC:1.10.99.3, GOC:ai, ISBN:0471331309]
synonym: "VDE" RELATED [EC:1.10.99.3]
synonym: "violaxanthin:ascorbate oxidoreductase activity" EXACT [EC:1.10.99.3]
xref: EC:1.10.99.3
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0046423
name: allene-oxide cyclase activity
namespace: molecular_function
def: "Catalysis of the reaction: (9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate = (15Z)-12-oxophyto-10,15-dienoate." [EC:5.3.99.6, RHEA:22595]
synonym: "(9Z)-(13S)-12,13-epoxyoctadeca-9,11,15-trienoate isomerase (cyclizing)" EXACT [EC:5.3.99.6]
xref: EC:5.3.99.6
xref: KEGG:R03402
xref: MetaCyc:ALLENE-OXIDE-CYCLASE-RXN
xref: RHEA:22595
is_a: GO:0009975 ! cyclase activity
is_a: GO:0016860 ! intramolecular oxidoreductase activity

[Term]
id: GO:0046424
name: ferulate 5-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: ferulic acid + NADPH + H+ + O2 = 5-hydroxyferulic acid + H2O + NADP+." [PMID:8692910, PMID:9880351]
xref: MetaCyc:RXN-1121
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H

[Term]
id: GO:0046425
name: regulation of JAK-STAT cascade
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the JAK-STAT signaling pathway." [GOC:bf]
is_a: GO:1904892 ! regulation of STAT cascade
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007259 ! JAK-STAT cascade
relationship: regulates GO:0007259 ! JAK-STAT cascade

[Term]
id: GO:0046426
name: negative regulation of JAK-STAT cascade
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the JAK-STAT signaling pathway activity." [GOC:bf]
synonym: "down regulation of JAK-STAT cascade" EXACT []
synonym: "down-regulation of JAK-STAT cascade" EXACT []
synonym: "downregulation of JAK-STAT cascade" EXACT []
synonym: "inhibition of JAK-STAT cascade" NARROW []
is_a: GO:0046425 ! regulation of JAK-STAT cascade
is_a: GO:1904893 ! negative regulation of STAT cascade
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007259 ! JAK-STAT cascade
relationship: negatively_regulates GO:0007259 ! JAK-STAT cascade

[Term]
id: GO:0046427
name: positive regulation of JAK-STAT cascade
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity." [GOC:bf]
synonym: "activation of JAK-STAT cascade" NARROW []
synonym: "stimulation of JAK-STAT cascade" NARROW []
synonym: "up regulation of JAK-STAT cascade" EXACT []
synonym: "up-regulation of JAK-STAT cascade" EXACT []
synonym: "upregulation of JAK-STAT cascade" EXACT []
is_a: GO:0046425 ! regulation of JAK-STAT cascade
is_a: GO:1904894 ! positive regulation of STAT cascade
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007259 ! JAK-STAT cascade
relationship: positively_regulates GO:0007259 ! JAK-STAT cascade

[Term]
id: GO:0046428
name: 1,4-dihydroxy-2-naphthoate octaprenyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,4-dihydroxy-2-naphthoate + polyprenylpyrophosphate = dimethylmenaquinone + diphosphate + CO2." [MetaCyc:DMK-RXN]
synonym: "1,4-Dihydroxy-2-naphtoate prenyltransferase activity" EXACT []
xref: EC:2.5.1.-
xref: MetaCyc:DMK-RXN
is_a: GO:0002094 ! polyprenyltransferase activity

[Term]
id: GO:0046429
name: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + 2 oxidized ferredoxin = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + 2 reduced ferredoxin." [EC:1.17.7.1, PMID:11752431]
subset: gosubset_prok
synonym: "(E)-4-hydroxy-3-methylbut-2-en-1-yl-diphosphate:oxidized ferredoxin oxidoreductase activity" EXACT systematic_synonym [EC:1.17.7.1]
synonym: "(E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase activity" EXACT [EC:1.17.7.1]
synonym: "1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase activity" EXACT [MetaCyc:HYDROXY-METHYL-BUTENYL-DIP]
synonym: "1-hydroxy-2-methyl-2-butenyl 4-diphosphate synthase activity" EXACT [MetaCyc:HYDROXY-METHYL-BUTENYL-DIP]
xref: EC:1.17.7.1
xref: KEGG:R08689
xref: MetaCyc:RXN0-882
is_a: GO:0052592 ! oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor

[Term]
id: GO:0046430
name: non-phosphorylated glucose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving non-phosphorylated forms of glucose." [GOC:ai]
subset: gosubset_prok
synonym: "non-phosphorylated glucose metabolism" EXACT []
is_a: GO:0006006 ! glucose metabolic process

[Term]
id: GO:0046431
name: (R)-4-hydroxymandelate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (R)-4-hydroxymandelate, the anion of a hydroxylated derivative of mandelate (alpha-hydroxybenzeneacetate)." [GOC:ai, ISBN:0198506732]
subset: gosubset_prok
synonym: "(R)-4-hydroxymandelate metabolism" EXACT []
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0046432
name: 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA, a derivative of coenzyme A." [GOC:ai]
subset: gosubset_prok
synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA metabolism" EXACT []
is_a: GO:0006732 ! coenzyme metabolic process
is_a: GO:0009150 ! purine ribonucleotide metabolic process
is_a: GO:0009167 ! purine ribonucleoside monophosphate metabolic process
is_a: GO:0046128 ! purine ribonucleoside metabolic process

[Term]
id: GO:0046433
name: 2-aminoethylphosphonate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 2-aminoethylphosphonate, most abundant and ubiquitous of naturally occurring phosphonates. It is typically found as a conjugate of glycans, lipids, and proteins, which in turn perform essential biochemical functions in specialized lower organisms." [GOC:ai, PMID:12107130]
subset: gosubset_prok
synonym: "2-aminoethylphosphonate metabolism" EXACT []
synonym: "2-phosphonoethylamine metabolic process" EXACT []
synonym: "2-phosphonoethylamine metabolism" EXACT []
synonym: "ciliatine metabolic process" EXACT []
synonym: "ciliatine metabolism" EXACT []
is_a: GO:0006793 ! phosphorus metabolic process
is_a: GO:1901160 ! primary amino compound metabolic process

[Term]
id: GO:0046434
name: organophosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of organophosphates, any phosphate-containing organic compound." [GOC:ai]
subset: gosubset_prok
synonym: "organophosphate breakdown" EXACT []
synonym: "organophosphate catabolism" EXACT []
synonym: "organophosphate degradation" EXACT []
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:1901575 ! organic substance catabolic process

[Term]
id: GO:0046435
name: 3-(3-hydroxy)phenylpropionate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 3-(3-hydroxy)phenylpropionate, a hydroxylated derivative of phenylpropionate." [GOC:ai]
subset: gosubset_prok
synonym: "3-(3-hydroxy)phenylpropionate metabolism" EXACT []
is_a: GO:0006066 ! alcohol metabolic process
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process

[Term]
id: GO:0046436
name: D-alanine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-alanine, the D-enantiomer of the amino acid alanine, i.e. (2R)-2-aminopropanoic acid." [CHEBI:15570, GOC:ai, GOC:jsg]
subset: gosubset_prok
synonym: "D-alanine metabolism" EXACT []
is_a: GO:0046144 ! D-alanine family amino acid metabolic process
is_a: GO:0046416 ! D-amino acid metabolic process

[Term]
id: GO:0046437
name: D-amino acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of D-amino acids, the D-enantiomers of amino acids." [GOC:ai, GOC:jsg]
subset: gosubset_prok
synonym: "D-amino acid anabolism" EXACT []
synonym: "D-amino acid biosynthesis" EXACT []
synonym: "D-amino acid formation" EXACT []
synonym: "D-amino acid synthesis" EXACT []
is_a: GO:0046416 ! D-amino acid metabolic process
is_a: GO:1901607 ! alpha-amino acid biosynthetic process

[Term]
id: GO:0046438
name: D-cysteine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-cysteine, (S)-2-amino-3-mercaptopropanoic acid, which occurs naturally in firefly luciferin." [GOC:ai]
subset: gosubset_prok
synonym: "D-cysteine metabolism" EXACT []
is_a: GO:0006534 ! cysteine metabolic process
is_a: GO:0046416 ! D-amino acid metabolic process

[Term]
id: GO:0046439
name: L-cysteine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving L-cysteine, the L-enantiomer of 2-amino-3-mercaptopropanoic acid, i.e. (2R)-2-amino-3-mercaptopropanoic acid." [CHEBI:17561, GOC:ai, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "L-cysteine metabolism" EXACT []
is_a: GO:0006534 ! cysteine metabolic process

[Term]
id: GO:0046440
name: L-lysine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving L-lysine, the L-enantiomer of (S)-2,6-diaminohexanoic acid, i.e. (2S)-2,6-diaminohexanoic acid." [CHEBI:18019, GOC:ai, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "L-lysine metabolism" EXACT []
is_a: GO:0006553 ! lysine metabolic process

[Term]
id: GO:0046441
name: D-lysine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-lysine, the D-enantiomer of lysine; i.e. (2R)-2,6-diaminohexanoic acid." [CHEBI:16855, GOC:ai, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "D-lysine metabolism" EXACT []
is_a: GO:0006553 ! lysine metabolic process
is_a: GO:0046416 ! D-amino acid metabolic process

[Term]
id: GO:0046442
name: aerobactin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aerobactin (C22H36N4O13), a hydroxamate iron transport compound. It is a conjugate of 6-(N-acetyl-N-hydroxylamine)-2-aminohexanoic acid and citric acid." [GOC:ai]
subset: gosubset_prok
synonym: "aerobactin metabolism" EXACT []
is_a: GO:0006575 ! cellular modified amino acid metabolic process
is_a: GO:0072350 ! tricarboxylic acid metabolic process

[Term]
id: GO:0046443
name: FAD metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving FAD, the oxidized form of flavin adenine dinucleotide." [CHEBI:16238, ISBN:0198506732]
subset: gosubset_prok
synonym: "FAD metabolism" EXACT []
synonym: "oxidized flavin adenine dinucleotide metabolic process" EXACT [GOC:curators]
synonym: "oxidized flavin adenine dinucleotide metabolism" EXACT [GOC:curators]
synonym: "oxidized flavin-adenine dinucleotide metabolic process" EXACT [GOC:curators]
synonym: "oxidized flavin-adenine dinucleotide metabolism" EXACT [GOC:curators]
is_a: GO:0072387 ! flavin adenine dinucleotide metabolic process

[Term]
id: GO:0046444
name: FMN metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving FMN, riboflavin 5'-(dihydrogen phosphate), a coenzyme for a number of oxidative enzymes including NADH dehydrogenase." [CHEBI:17621, GOC:ai]
subset: gosubset_prok
synonym: "FMN metabolism" EXACT []
is_a: GO:0006732 ! coenzyme metabolic process
is_a: GO:0009161 ! ribonucleoside monophosphate metabolic process
is_a: GO:0009259 ! ribonucleotide metabolic process
is_a: GO:0042726 ! flavin-containing compound metabolic process

[Term]
id: GO:0046445
name: benzyl isoquinoline alkaloid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving benzyl isoquinoline alkaloids, compounds with bicyclic N-containing aromatic rings." [GOC:ai, ISBN:0198506732]
subset: gosubset_prok
synonym: "benzyl isoquinoline alkaloid metabolism" EXACT []
is_a: GO:0033076 ! isoquinoline alkaloid metabolic process

[Term]
id: GO:0046446
name: purine alkaloid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving purine alkaloids, compounds derived from purine and composed of an N-containing double ring structure." [GOC:ai]
subset: gosubset_prok
synonym: "purine alkaloid metabolism" EXACT []
is_a: GO:0009820 ! alkaloid metabolic process
is_a: GO:0072521 ! purine-containing compound metabolic process

[Term]
id: GO:0046447
name: terpenoid indole alkaloid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving terpenoid indole alkaloids, compounds formed from the condensation of tryptamine (derived from tryptophan) and secologanin (derived from geranyl pyrophosphate)." [GOC:ai, http://rycomusa.com/aspp2000/public/P29/0525.html]
subset: gosubset_prok
synonym: "terpenoid indole alkaloid metabolism" EXACT []
is_a: GO:0035834 ! indole alkaloid metabolic process

[Term]
id: GO:0046448
name: tropane alkaloid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tropane alkaloids, compounds containing the 8-methyl-8-azabicyclo(3.2.1)octane ring system." [GOC:ai, ISBN:0198506732]
subset: gosubset_prok
synonym: "tropane alkaloid metabolism" EXACT []
is_a: GO:0009820 ! alkaloid metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process

[Term]
id: GO:0046449
name: creatinine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving creatinine, 2-amino-1,5-dihydro-1-methyl-4H-imidazol-4-one, an end product of creatine metabolism and a normal constituent of urine." [ISBN:0198506732]
subset: gosubset_prok
synonym: "creatinine metabolism" EXACT []
is_a: GO:0072338 ! cellular lactam metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process

[Term]
id: GO:0046450
name: dethiobiotin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dethiobiotin, a derivative of biotin formed by replacing the sulfur atom by two hydrogen atoms." [ISBN:0198506732]
subset: gosubset_prok
synonym: "desthiobiotin metabolic process" EXACT []
synonym: "desthiobiotin metabolism" EXACT []
synonym: "dethiobiotin metabolism" EXACT []
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0043603 ! cellular amide metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process

[Term]
id: GO:0046451
name: diaminopimelate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving diaminopimelate, the anion of the dicarboxylic acid 2,6-diaminoheptanedioic acid. It is an intermediate in lysine biosynthesis and as a component (as meso-diaminopimelate) of the peptidoglycan of Gram-negative bacterial cell walls." [GOC:ai, ISBN:0198506732]
subset: gosubset_prok
synonym: "diaminopimelate metabolism" EXACT []
is_a: GO:0006520 ! cellular amino acid metabolic process
is_a: GO:0043648 ! dicarboxylic acid metabolic process

[Term]
id: GO:0046452
name: dihydrofolate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dihydrofolate, the dihydroxylated derivative of folate." [ISBN:0198506732]
subset: gosubset_prok
synonym: "dihydrofolate metabolism" EXACT []
synonym: "dihydrofolate reduction" NARROW []
is_a: GO:0006760 ! folic acid-containing compound metabolic process
is_a: GO:0043648 ! dicarboxylic acid metabolic process

[Term]
id: GO:0046453
name: dipyrrin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dipyrrins (pyrromethanes), compounds containing two pyrrole rings linked through a methine, -CH=, group." [http://www.chem.qmw.ac.uk/iupac/class/tetpy.html#03]
subset: gosubset_prok
synonym: "dipyrrin metabolism" EXACT []
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process

[Term]
id: GO:0046454
name: dimethylsilanediol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dimethylsilanediol, the smallest member of the dialkylsilanediols. Dimethylsilanediol is the monomer of polydimethylsiloxane, a compound which can be found in a wide range of industrial and consumer products." [GOC:ai]
subset: gosubset_prok
synonym: "dimethylsilanediol metabolism" EXACT []
is_a: GO:0018945 ! organosilicon metabolic process
is_a: GO:0044281 ! small molecule metabolic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0046455
name: organosilicon catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of organosilicons, any organic compound that contains silicon." [GOC:ai]
subset: gosubset_prok
synonym: "organosilicon breakdown" EXACT []
synonym: "organosilicon catabolism" EXACT []
synonym: "organosilicon degradation" EXACT []
synonym: "organosilicone catabolic process" EXACT []
synonym: "organosilicone catabolism" EXACT []
is_a: GO:0018945 ! organosilicon metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:1901575 ! organic substance catabolic process

[Term]
id: GO:0046456
name: icosanoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of icosanoids, any of a group of C20 polyunsaturated fatty acids." [ISBN:0198506732]
subset: gosubset_prok
synonym: "eicosanoid biosynthesis" EXACT []
synonym: "eicosanoid biosynthetic process" EXACT []
synonym: "icosanoid anabolism" EXACT []
synonym: "icosanoid biosynthesis" EXACT []
synonym: "icosanoid formation" EXACT []
synonym: "icosanoid synthesis" EXACT []
xref: Wikipedia:Eicosanoid
is_a: GO:0006690 ! icosanoid metabolic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
is_a: GO:1901570 ! fatty acid derivative biosynthetic process

[Term]
id: GO:0046457
name: prostanoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of prostanoids, any compound based on or derived from the prostanoate structure." [GOC:ai]
subset: gosubset_prok
synonym: "prostanoid anabolism" EXACT []
synonym: "prostanoid biosynthesis" EXACT []
synonym: "prostanoid formation" EXACT []
synonym: "prostanoid synthesis" EXACT []
xref: Wikipedia:Prostanoid#Biosynthesis
is_a: GO:0006636 ! unsaturated fatty acid biosynthetic process
is_a: GO:0006692 ! prostanoid metabolic process
is_a: GO:0046456 ! icosanoid biosynthetic process

[Term]
id: GO:0046458
name: hexadecanal metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving hexadecanal, the C16 straight chain aldehyde." [http://chemfinder.cambridgesoft.com/]
subset: gosubset_prok
synonym: "hexadecanal metabolism" EXACT []
is_a: GO:0006081 ! cellular aldehyde metabolic process

[Term]
id: GO:0046459
name: short-chain fatty acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fatty acids with a chain length of less than C6." [CHEBI:26666, ISBN:0198506732]
subset: gosubset_prok
synonym: "short-chain fatty acid metabolism" EXACT []
is_a: GO:0006631 ! fatty acid metabolic process

[Term]
id: GO:0046460
name: neutral lipid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of neutral lipids, lipids only soluble in solvents of very low polarity." [GOC:ai]
subset: gosubset_prok
synonym: "neutral lipid anabolism" EXACT []
synonym: "neutral lipid biosynthesis" EXACT []
synonym: "neutral lipid formation" EXACT []
synonym: "neutral lipid synthesis" EXACT []
is_a: GO:0006638 ! neutral lipid metabolic process
is_a: GO:0008610 ! lipid biosynthetic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0046461
name: neutral lipid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of neutral lipids, lipids only soluble in solvents of very low polarity." [GOC:ai]
subset: gosubset_prok
synonym: "neutral lipid breakdown" EXACT []
synonym: "neutral lipid catabolism" EXACT []
synonym: "neutral lipid degradation" EXACT []
is_a: GO:0006638 ! neutral lipid metabolic process
is_a: GO:0044242 ! cellular lipid catabolic process

[Term]
id: GO:0046462
name: monoacylglycerol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified." [ISBN:0198506732]
subset: gosubset_prok
synonym: "monoacylglycerol metabolism" EXACT []
synonym: "monoglyceride metabolic process" EXACT []
synonym: "monoglyceride metabolism" EXACT []
is_a: GO:0006639 ! acylglycerol metabolic process

[Term]
id: GO:0046463
name: acylglycerol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids." [GOC:ai]
subset: gosubset_prok
synonym: "acylglycerol anabolism" EXACT []
synonym: "acylglycerol biosynthesis" EXACT []
synonym: "acylglycerol formation" EXACT []
synonym: "acylglycerol synthesis" EXACT []
is_a: GO:0006639 ! acylglycerol metabolic process
is_a: GO:0045017 ! glycerolipid biosynthetic process
is_a: GO:0046460 ! neutral lipid biosynthetic process

[Term]
id: GO:0046464
name: acylglycerol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids." [GOC:ai]
subset: gosubset_prok
synonym: "acylglycerol breakdown" EXACT []
synonym: "acylglycerol catabolism" EXACT []
synonym: "acylglycerol degradation" EXACT []
is_a: GO:0006639 ! acylglycerol metabolic process
is_a: GO:0046461 ! neutral lipid catabolic process
is_a: GO:0046503 ! glycerolipid catabolic process

[Term]
id: GO:0046465
name: dolichyl diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dolichyl diphosphate, a diphosphorylated dolichol derivative. In eukaryotes, these function as carriers of mono- and oligosaccharide residues in the glycosylation of lipids and proteins within intracellular membranes." [ISBN:0198506732]
synonym: "dolichyl diphosphate metabolism" EXACT []
is_a: GO:0006644 ! phospholipid metabolic process

[Term]
id: GO:0046466
name: membrane lipid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of membrane lipids, any lipid found in or associated with a biological membrane." [GOC:ai]
subset: gosubset_prok
synonym: "membrane lipid breakdown" EXACT []
synonym: "membrane lipid catabolism" EXACT []
synonym: "membrane lipid degradation" EXACT []
synonym: "membrane lipid peroxidation" BROAD [GOC:tb]
is_a: GO:0006643 ! membrane lipid metabolic process
is_a: GO:0044242 ! cellular lipid catabolic process

[Term]
id: GO:0046467
name: membrane lipid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of membrane lipids, any lipid found in or associated with a biological membrane." [GOC:ai]
subset: gosubset_prok
synonym: "membrane lipid anabolism" EXACT []
synonym: "membrane lipid biosynthesis" EXACT []
synonym: "membrane lipid formation" EXACT []
synonym: "membrane lipid synthesis" EXACT []
is_a: GO:0006643 ! membrane lipid metabolic process
is_a: GO:0008610 ! lipid biosynthetic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0046468
name: phosphatidyl-N-monomethylethanolamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phosphatidyl-N-monomethylethanolamine (PMME), a derivative of phosphatidylethanolamine with a methylated amine group. Present in trace levels in plants and slightly higher in bacteria." [http://www.lipid.co.uk]
subset: gosubset_prok
synonym: "phosphatidyl-N-monomethylethanolamine metabolism" EXACT []
synonym: "PMME metabolic process" EXACT []
synonym: "PMME metabolism" EXACT []
is_a: GO:0046337 ! phosphatidylethanolamine metabolic process

[Term]
id: GO:0046469
name: platelet activating factor metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving platelet activating factor, 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphocholine, where alkyl = hexadecyl or octadecyl. Platelet activating factor is an inflammatory mediator released from a variety of cells in response to various stimuli." [ISBN:0198547684]
synonym: "PAF metabolic process" EXACT []
synonym: "PAF metabolism" EXACT []
synonym: "platelet activating factor metabolism" EXACT []
is_a: GO:0006650 ! glycerophospholipid metabolic process
is_a: GO:0042439 ! ethanolamine-containing compound metabolic process
is_a: GO:0097164 ! ammonium ion metabolic process

[Term]
id: GO:0046470
name: phosphatidylcholine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes." [ISBN:0198506732]
subset: gosubset_prok
synonym: "phosphatidylcholine metabolism" EXACT []
is_a: GO:0006650 ! glycerophospholipid metabolic process
is_a: GO:0042439 ! ethanolamine-containing compound metabolic process
is_a: GO:0097164 ! ammonium ion metabolic process

[Term]
id: GO:0046471
name: phosphatidylglycerol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol. They are important constituents of cell membranes." [ISBN:0198506732]
subset: gosubset_prok
synonym: "phosphatidylglycerol metabolism" EXACT []
is_a: GO:0006650 ! glycerophospholipid metabolic process

[Term]
id: GO:0046473
name: phosphatidic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids." [ISBN:0198506732]
subset: gosubset_prok
synonym: "phosphatidic acid metabolism" EXACT []
is_a: GO:0006650 ! glycerophospholipid metabolic process

[Term]
id: GO:0046474
name: glycerophospholipid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732]
subset: gosubset_prok
synonym: "glycerophospholipid anabolism" EXACT []
synonym: "glycerophospholipid biosynthesis" EXACT []
synonym: "glycerophospholipid formation" EXACT []
synonym: "glycerophospholipid synthesis" EXACT []
synonym: "phosphoglyceride biosynthesis" EXACT []
synonym: "phosphoglyceride biosynthetic process" EXACT []
is_a: GO:0006650 ! glycerophospholipid metabolic process
is_a: GO:0008654 ! phospholipid biosynthetic process
is_a: GO:0045017 ! glycerolipid biosynthetic process

[Term]
id: GO:0046475
name: glycerophospholipid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732]
subset: gosubset_prok
synonym: "glycerophospholipid breakdown" EXACT []
synonym: "glycerophospholipid catabolism" EXACT []
synonym: "glycerophospholipid degradation" EXACT []
synonym: "phosphoglyceride catabolic process" EXACT []
synonym: "phosphoglyceride catabolism" EXACT []
is_a: GO:0006650 ! glycerophospholipid metabolic process
is_a: GO:0009395 ! phospholipid catabolic process
is_a: GO:0046503 ! glycerolipid catabolic process

[Term]
id: GO:0046476
name: glycosylceramide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of a monosaccharide (or derivative) by a ceramide group." [GOC:ai]
subset: gosubset_prok
synonym: "glycosylceramide anabolism" EXACT []
synonym: "glycosylceramide biosynthesis" EXACT []
synonym: "glycosylceramide formation" EXACT []
synonym: "glycosylceramide synthesis" EXACT []
is_a: GO:0006677 ! glycosylceramide metabolic process
is_a: GO:0006688 ! glycosphingolipid biosynthetic process
is_a: GO:0046513 ! ceramide biosynthetic process

[Term]
id: GO:0046477
name: glycosylceramide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of a monosaccharide (or derivative) by a ceramide group." [GOC:ai]
subset: gosubset_prok
synonym: "glycosylceramide breakdown" EXACT []
synonym: "glycosylceramide catabolism" EXACT []
synonym: "glycosylceramide degradation" EXACT []
is_a: GO:0006677 ! glycosylceramide metabolic process
is_a: GO:0046479 ! glycosphingolipid catabolic process
is_a: GO:0046514 ! ceramide catabolic process

[Term]
id: GO:0046478
name: lactosylceramide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lactosylceramides, Gal-beta-(1->4)-Glc-beta-(1->1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group. They are the precursors of both gangliosides and globosides." [ISBN:0198506732]
subset: gosubset_prok
synonym: "lactosylceramide metabolism" EXACT []
is_a: GO:0006672 ! ceramide metabolic process
is_a: GO:0006687 ! glycosphingolipid metabolic process

[Term]
id: GO:0046479
name: glycosphingolipid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide." [ISBN:0198506732]
subset: gosubset_prok
synonym: "glycosphingolipid breakdown" EXACT []
synonym: "glycosphingolipid catabolism" EXACT []
synonym: "glycosphingolipid degradation" EXACT []
is_a: GO:0006687 ! glycosphingolipid metabolic process
is_a: GO:0019377 ! glycolipid catabolic process
is_a: GO:0030149 ! sphingolipid catabolic process

[Term]
id: GO:0046480
name: galactolipid galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 mono-beta-D-galactosyldiacylglycerol = alpha-D-galactosyl-beta-D-galactosyldiacylglycerol + 1,2-diacylglycerol." [EC:2.4.1.184]
synonym: "3-(beta-D-galactosyl)-1,2-diacyl-sn-glycerol:mono-3-(beta-D-galactosyl)-1,2-diacyl-sn-glycerol beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.184]
synonym: "DGDG synthase activity" BROAD [EC:2.4.1.184]
synonym: "digalactosyldiacylglycerol synthase activity" BROAD [EC:2.4.1.184]
synonym: "galactolipid-galactolipid galactosyltransferase activity" EXACT [EC:2.4.1.184]
synonym: "galactolipid:galactolipid galactosyltransferase activity" EXACT []
synonym: "GGGT activity" EXACT [EC:2.4.1.184]
synonym: "interlipid galactosyltransferase activity" RELATED [EC:2.4.1.184]
xref: EC:2.4.1.184
xref: MetaCyc:RXN-1226
xref: RHEA:15924
is_a: GO:0008378 ! galactosyltransferase activity

[Term]
id: GO:0046481
name: digalactosyldiacylglycerol synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + UDP-D-galactose = 3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-1,2-diacyl-sn-glycerol + H(+) + UDP." [EC:2.4.1.241, RHEA:10523]
synonym: "DGD1" NARROW []
synonym: "DGD2" NARROW []
synonym: "DGDG synthase activity" BROAD [EC:2.4.1.241]
synonym: "UDP-galactose-dependent DGDG synthase activity" EXACT [EC:2.4.1.241]
synonym: "UDP-galactose-dependent digalactosyldiacylglycerol synthase activity" EXACT [EC:2.4.1.241]
synonym: "UDP-galactose:3-(beta-D-galactosyl)-1,2-diacyl-sn-glycerol 6-alpha-galactosyltransferase activity" EXACT [EC:2.4.1.241]
synonym: "UDP-galactose:MGDG galactosyltransferase activity" EXACT []
xref: EC:2.4.1.241
xref: KEGG:R04469
xref: MetaCyc:RXN-1225
xref: RHEA:10523
xref: Wikipedia:Digalactosyldiacylglycerol_synthase
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0046482
name: para-aminobenzoic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving para-aminobenzoic acid, an intermediate in the synthesis of folic acid, a compound which some organisms, e.g. prokaryotes, eukaryotic microbes, and plants, can synthesize de novo. Others, notably mammals, cannot. In yeast, it is present as a factor in the B complex of vitamins." [ISBN:0198506732, PMID:11377864, PMID:11960743]
subset: gosubset_prok
synonym: "4-aminobenzoic acid metabolic process" EXACT []
synonym: "4-aminobenzoic acid metabolism" EXACT []
synonym: "p-aminobenzoic acid metabolic process" EXACT []
synonym: "p-aminobenzoic acid metabolism" EXACT []
synonym: "PABA metabolic process" EXACT []
synonym: "PABA metabolism" EXACT []
synonym: "para-aminobenzoic acid metabolism" EXACT []
synonym: "vitamin Bx metabolic process" EXACT []
synonym: "vitamin Bx metabolism" EXACT []
is_a: GO:0009072 ! aromatic amino acid family metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process

[Term]
id: GO:0046483
name: heterocycle metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [CHEBI:5686, ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
synonym: "heterocycle metabolism" EXACT []
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0046484
name: oxazole or thiazole metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving oxazole or thiazole, five-membered heterocyclic ring structures containing an oxygen and a sulfur, respectively, in the 1-position and a nitrogen in the 3-position." [CHEBI:35790, CHEBI:48901, GOC:curators]
subset: gosubset_prok
synonym: "oxazole or thiazole metabolism" EXACT []
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0046485
name: ether lipid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ether lipids, lipids that contain (normally) one lipid alcohol in ether linkage to one of the carbon atoms (normally C-1) of glycerol." [ISBN:0198506732, PMID:15337120]
subset: gosubset_prok
synonym: "ether lipid metabolism" EXACT []
synonym: "plasmalogen metabolic process" NARROW []
xref: Wikipedia:Ether_lipid
is_a: GO:0006662 ! glycerol ether metabolic process
is_a: GO:0044255 ! cellular lipid metabolic process

[Term]
id: GO:0046486
name: glycerolipid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycerolipids, any lipid with a glycerol backbone. Diacylglycerol and phosphatidate are key lipid intermediates of glycerolipid biosynthesis." [GOC:ai, PMID:8906569]
subset: gosubset_prok
synonym: "glycerolipid metabolism" EXACT []
is_a: GO:0044255 ! cellular lipid metabolic process

[Term]
id: GO:0046487
name: glyoxylate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glyoxylate, the anion of glyoxylic acid, HOC-COOH." [ISBN:0198506732]
subset: gosubset_prok
synonym: "glyoxylate metabolism" EXACT []
xref: Reactome:REACT_106613 "Glyoxylate metabolism, Drosophila melanogaster"
xref: Reactome:REACT_115415 "Glyoxylate metabolism, Schizosaccharomyces pombe"
xref: Reactome:REACT_115484 "Glyoxylate metabolism, Mycobacterium tuberculosis"
xref: Reactome:REACT_16925 "Glyoxylate metabolism, Homo sapiens"
xref: Reactome:REACT_28376 "Glyoxylate metabolism, Gallus gallus"
xref: Reactome:REACT_31797 "Glyoxylate metabolism, Rattus norvegicus"
xref: Reactome:REACT_31873 "Glyoxylate metabolism, Caenorhabditis elegans"
xref: Reactome:REACT_77943 "Glyoxylate metabolism, Oryza sativa"
xref: Reactome:REACT_78851 "Glyoxylate metabolism, Danio rerio"
xref: Reactome:REACT_82666 "Glyoxylate metabolism, Saccharomyces cerevisiae"
xref: Reactome:REACT_84343 "Glyoxylate metabolism, Dictyostelium discoideum"
xref: Reactome:REACT_84443 "Glyoxylate metabolism, Taeniopygia guttata"
xref: Reactome:REACT_88386 "Glyoxylate metabolism, Mus musculus"
xref: Reactome:REACT_89087 "Glyoxylate metabolism, Staphylococcus aureus N315"
xref: Reactome:REACT_89811 "Glyoxylate metabolism, Canis familiaris"
xref: Reactome:REACT_93066 "Glyoxylate metabolism, Bos taurus"
xref: Reactome:REACT_95634 "Glyoxylate metabolism, Xenopus tropicalis"
xref: Reactome:REACT_96776 "Glyoxylate metabolism, Arabidopsis thaliana"
xref: Reactome:REACT_96913 "Glyoxylate metabolism, Sus scrofa"
xref: Reactome:REACT_97620 "Glyoxylate metabolism, Escherichia coli"
is_a: GO:0006081 ! cellular aldehyde metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0046488
name: phosphatidylinositol metabolic process
namespace: biological_process
alt_id: GO:0030384
def: "The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [CHEBI:28874, ISBN:0198506732]
subset: gosubset_prok
synonym: "phosphatidylinositol metabolism" EXACT []
synonym: "phosphoinositide metabolic process" EXACT []
synonym: "phosphoinositide metabolism" EXACT []
synonym: "PtdIns metabolic process" EXACT []
synonym: "PtdIns metabolism" EXACT []
is_a: GO:0006650 ! glycerophospholipid metabolic process

[Term]
id: GO:0046490
name: isopentenyl diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving isopentenyl diphosphate, an isomer of dimethylallyl diphosphate and the key precursor of all isoprenoids." [ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
synonym: "IPP metabolic process" EXACT []
synonym: "IPP metabolism" EXACT []
synonym: "isopentenyl diphosphate metabolism" EXACT []
synonym: "isopentenyl pyrophosphate metabolic process" EXACT []
synonym: "isopentenyl pyrophosphate metabolism" EXACT []
is_a: GO:0006644 ! phospholipid metabolic process

[Term]
id: GO:0046491
name: L-methylmalonyl-CoA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving L-methylmalonyl-CoA, the L-enantiomer of 2-carboxypropanoyl-CoA. S-methylmalonyl-CoA is an intermediate in the beta oxidation of odd-numbered fatty acids in animals." [GOC:jsg, GOC:mah, ISBN:0198506732]
subset: gosubset_prok
synonym: "L-methylmalonyl-CoA metabolism" EXACT []
is_a: GO:0015936 ! coenzyme A metabolic process
is_a: GO:0035337 ! fatty-acyl-CoA metabolic process

[Term]
id: GO:0046492
name: heme b metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving heme b, a Fe(II) porphyrin complex readily isolated from the hemoglobin of beef blood, but also found in other proteins including other hemoglobins, myoglobins, cytochromes P-450, catalases, peroxidases as well as b type cytochromes." [GOC:yaf, http://www.chem.qmul.ac.uk/iupac/bioinorg/PR.html#25, MetaCyc:PROTOHEME]
subset: gosubset_prok
synonym: "haem b metabolic process" EXACT []
synonym: "haem b metabolism" EXACT []
synonym: "heme b metabolism" EXACT []
synonym: "protoheme metabolic process" EXACT []
synonym: "protoheme metabolism" EXACT []
is_a: GO:0042168 ! heme metabolic process

[Term]
id: GO:0046493
name: lipid A metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lipid A, the glycolipid group of bacterial lipopolysaccharides, consisting of six fatty acyl chains linked to two glucosamine residues." [ISBN:0198506732]
subset: gosubset_prok
synonym: "lipid A metabolism" EXACT []
is_a: GO:0006644 ! phospholipid metabolic process
is_a: GO:0006664 ! glycolipid metabolic process
is_a: GO:1901269 ! lipooligosaccharide metabolic process

[Term]
id: GO:0046494
name: rhizobactin 1021 metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving rhizobactin 1021, (E)-4-((3-(acetylhydroxyamino)propyl)-amino)-2-hydroxy-(2-(2-(3-(hydroxy(1-oxo-2-decenyl)amino)propyl)amino)-2-oxoethyl)-4-oxobutanoic acid, a siderophore produced by Sinorhizobium meliloti." [MetaCyc:PWY-761, PMID:11274118]
subset: gosubset_prok
synonym: "rhizobactin 1021 metabolism" EXACT []
is_a: GO:0009237 ! siderophore metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0043603 ! cellular amide metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process
is_a: GO:1902644 ! tertiary alcohol metabolic process

[Term]
id: GO:0046495
name: nicotinamide riboside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nicotinamide riboside, the product of the formation of a glycosidic bond between ribose and nicotinamide." [CHEBI:15927, ISBN:0198506732]
subset: gosubset_prok
synonym: "N-ribosylnicotinamide metabolic process" EXACT [CHEBI:15927]
synonym: "nicotinamide riboside metabolism" EXACT []
is_a: GO:0070637 ! pyridine nucleoside metabolic process

[Term]
id: GO:0046496
name: nicotinamide nucleotide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nicotinamide nucleotides, any nucleotide that contains combined nicotinamide." [ISBN:0198506732]
subset: gosubset_prok
synonym: "nicotinamide nucleotide metabolism" EXACT []
is_a: GO:0019362 ! pyridine nucleotide metabolic process

[Term]
id: GO:0046497
name: nicotinate nucleotide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nicotinamide nucleotides, any nucleotide that contains combined nicotinate (pyridine 3-carboxylic acid, or niacin)." [ISBN:0198506732]
subset: gosubset_prok
synonym: "nicotinate nucleotide metabolism" EXACT []
is_a: GO:0019362 ! pyridine nucleotide metabolic process

[Term]
id: GO:0046498
name: S-adenosylhomocysteine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving S-adenosylhomocysteine; the L-enantiomer is formed from S-adenosylmethionine and is a strong inhibitor of S-adenosylmethionine-mediated methylation reactions. It can be cleaved to form adenosine and homocysteine." [ISBN:0198506732]
subset: gosubset_prok
synonym: "S-adenosylhomocysteine metabolism" EXACT []
is_a: GO:0006575 ! cellular modified amino acid metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0046128 ! purine ribonucleoside metabolic process
is_a: GO:1901605 ! alpha-amino acid metabolic process

[Term]
id: GO:0046499
name: S-adenosylmethioninamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving S-adenosylmethioninamine, (5-deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt." [GOC:mah, MetaCyc:S-ADENOSYLMETHIONINAMINE]
subset: gosubset_prok
synonym: "S-adenosylmethioninamine metabolism" EXACT []
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0046128 ! purine ribonucleoside metabolic process
is_a: GO:0097164 ! ammonium ion metabolic process

[Term]
id: GO:0046500
name: S-adenosylmethionine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "S-adenosyl methionine metabolic process" EXACT []
synonym: "S-adenosyl methionine metabolism" EXACT []
synonym: "S-adenosylmethionine metabolism" EXACT []
synonym: "SAM metabolic process" EXACT []
is_a: GO:0006575 ! cellular modified amino acid metabolic process
is_a: GO:0006732 ! coenzyme metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0046128 ! purine ribonucleoside metabolic process

[Term]
id: GO:0046501
name: protoporphyrinogen IX metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving protoporphyrinogen IX, the specific substrate for the enzyme ferrochelatase, which catalyzes the insertion of iron to form protoheme. It is probably also the substrate for chlorophyll formation." [ISBN:0198506732]
comment: See also the molecular function term 'ferrochelatase activity ; GO:0004325'.
subset: gosubset_prok
synonym: "protoporphyrinogen IX metabolism" EXACT []
is_a: GO:0006778 ! porphyrin-containing compound metabolic process

[Term]
id: GO:0046502
name: uroporphyrinogen III metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving uroporphyrinogen III, a precursor for synthesis of vitamin B12, chlorophyll, and heme in organisms that produce these compounds." [GOC:ai]
subset: gosubset_prok
synonym: "uroporphyrinogen III metabolism" EXACT []
is_a: GO:0006778 ! porphyrin-containing compound metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0046503
name: glycerolipid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycerolipids, any lipid with a glycerol backbone." [GOC:ai]
subset: gosubset_prok
synonym: "glycerolipid breakdown" EXACT []
synonym: "glycerolipid catabolism" EXACT []
synonym: "glycerolipid degradation" EXACT []
is_a: GO:0044242 ! cellular lipid catabolic process
is_a: GO:0046486 ! glycerolipid metabolic process

[Term]
id: GO:0046504
name: glycerol ether biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol." [GOC:ai]
subset: gosubset_prok
synonym: "glycerol ether anabolism" EXACT []
synonym: "glycerol ether biosynthesis" EXACT []
synonym: "glycerol ether formation" EXACT []
synonym: "glycerol ether synthesis" EXACT []
is_a: GO:0006662 ! glycerol ether metabolic process
is_a: GO:0044249 ! cellular biosynthetic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:1901503 ! ether biosynthetic process

[Term]
id: GO:0046505
name: sulfolipid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sulfolipids, any compound containing a sulfonic acid residue joined by a carbon-sulfur bond to a lipid." [PMID:9751667]
subset: gosubset_prok
synonym: "sulfolipid metabolism" EXACT []
synonym: "sulpholipid metabolic process" EXACT []
synonym: "sulpholipid metabolism" EXACT []
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0043436 ! oxoacid metabolic process
is_a: GO:0044255 ! cellular lipid metabolic process

[Term]
id: GO:0046506
name: sulfolipid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sulfolipid, a compound containing a sulfonic acid residue joined by a carbon-sulfur bond to a lipid." [PMID:9751667]
subset: gosubset_prok
synonym: "sulfolipid anabolism" EXACT []
synonym: "sulfolipid biosynthesis" EXACT []
synonym: "sulfolipid formation" EXACT []
synonym: "sulfolipid synthesis" EXACT []
synonym: "sulpholipid biosynthesis" EXACT []
synonym: "sulpholipid biosynthetic process" EXACT []
xref: AraCyc:PWYQT-4427
is_a: GO:0008610 ! lipid biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:0046505 ! sulfolipid metabolic process

[Term]
id: GO:0046507
name: UDPsulfoquinovose synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: sulfite + UDP-D-glucose = H(2)O + UDP-6-sulfoquinovose." [EC:3.13.1.1, RHEA:13200]
synonym: "sulfite:UDP-glucose sulfotransferase activity" EXACT []
synonym: "UDP-6-sulfo-6-deoxyglucose sulfohydrolase activity" EXACT [EC:3.13.1.1]
synonym: "UDP-sulfoquinovose synthase activity" EXACT [EC:3.13.1.1]
synonym: "UDPsulphoquinovose synthase activity" EXACT []
xref: EC:3.13.1.1
xref: KEGG:R05775
xref: MetaCyc:RXN-1223
xref: RHEA:13200
is_a: GO:0046508 ! hydrolase activity, acting on carbon-sulfur bonds

[Term]
id: GO:0046508
name: hydrolase activity, acting on carbon-sulfur bonds
namespace: molecular_function
def: "Catalysis of the hydrolysis of any carbon-sulfur bond, C-S." [GOC:jl]
subset: gosubset_prok
synonym: "hydrolase activity, acting on carbon-sulphur bonds" EXACT []
xref: EC:3.13
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0046509
name: 1,2-diacylglycerol 3-beta-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-diacyl-sn-glycerol + UDP-D-galactose = 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP." [EC:2.4.1.46, RHEA:14948]
synonym: "1-beta-MGDG activity" EXACT [EC:2.4.1.46]
synonym: "1beta-MGDG" RELATED [EC:2.4.1.46]
synonym: "MGDG synthase activity" EXACT []
synonym: "monogalactosyldiacylglycerol synthase activity" EXACT []
synonym: "UDP galactose-1,2-diacylglycerol galactosyltransferase activity" EXACT []
synonym: "UDP-galactose-diacylglyceride galactosyltransferase activity" EXACT []
synonym: "UDP-galactose:1,2-diacyl-sn-glycerol 3-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.46]
synonym: "UDP-galactose:diacylglycerol galactosyltransferase activity" EXACT []
synonym: "UDPgalactose:1,2-diacylglycerol 3-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.46]
synonym: "uridine diphosphogalactose-1,2-diacylglycerol galactosyltransferase activity" EXACT []
xref: EC:2.4.1.46
xref: KEGG:R02691
xref: MetaCyc:2.4.1.46-RXN
xref: RHEA:14948
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0046510
name: UDP-sulfoquinovose:DAG sulfoquinovosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-sulfoquinovose + 1,2-diacylglycerol = sulfoquinovosyldiacylglycerol + UDP." [MetaCyc:RXN-1224]
synonym: "sulfolipid synthase" BROAD []
synonym: "UDP-sulphoquinovose:DAG sulphoquinovosyltransferase activity" EXACT []
xref: MetaCyc:RXN-1224
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0046511
name: sphinganine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sphinganine, D-erythro-2-amino-1,3-octadecanediol." [GOC:ai]
subset: gosubset_prok
synonym: "dihydrosphingosine biosynthesis" EXACT []
synonym: "dihydrosphingosine biosynthetic process" EXACT []
synonym: "sphinganine anabolism" EXACT []
synonym: "sphinganine biosynthesis" EXACT []
synonym: "sphinganine formation" EXACT []
synonym: "sphinganine synthesis" EXACT []
is_a: GO:0006667 ! sphinganine metabolic process
is_a: GO:0034312 ! diol biosynthetic process
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process
is_a: GO:0046520 ! sphingoid biosynthetic process

[Term]
id: GO:0046512
name: sphingosine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues." [GOC:ma, ISBN:0198506732]
subset: gosubset_prok
synonym: "sphingosine anabolism" EXACT []
synonym: "sphingosine biosynthesis" EXACT []
synonym: "sphingosine formation" EXACT []
synonym: "sphingosine synthesis" EXACT []
is_a: GO:0006670 ! sphingosine metabolic process
is_a: GO:0034312 ! diol biosynthetic process
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process
is_a: GO:0046520 ! sphingoid biosynthetic process

[Term]
id: GO:0046513
name: ceramide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid." [GOC:ai]
subset: gosubset_prok
synonym: "ceramide anabolism" EXACT []
synonym: "ceramide biosynthesis" EXACT []
synonym: "ceramide formation" EXACT []
synonym: "ceramide synthesis" EXACT []
is_a: GO:0006672 ! ceramide metabolic process
is_a: GO:0030148 ! sphingolipid biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process

[Term]
id: GO:0046514
name: ceramide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ceramides, any N-acetylated sphingoid." [GOC:ai]
subset: gosubset_prok
synonym: "ceramide breakdown" EXACT []
synonym: "ceramide catabolism" EXACT []
synonym: "ceramide degradation" EXACT []
is_a: GO:0006672 ! ceramide metabolic process
is_a: GO:0030149 ! sphingolipid catabolic process

[Term]
id: GO:0046516
name: hypusine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine." [GOC:ai]
subset: gosubset_prok
synonym: "hypusine metabolism" EXACT []
is_a: GO:0006575 ! cellular modified amino acid metabolic process
is_a: GO:1901605 ! alpha-amino acid metabolic process

[Term]
id: GO:0046517
name: octamethylcyclotetrasiloxane catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of octamethylcyclotetrasiloxane, a cyclic silicone-oxygen ring compound with two methyl groups attached to each silicone atom." [GOC:ai, http://chemfinder.cambridgesoft.com/]
subset: gosubset_prok
synonym: "octamethylcyclotetrasiloxane breakdown" EXACT []
synonym: "octamethylcyclotetrasiloxane catabolism" EXACT []
synonym: "octamethylcyclotetrasiloxane degradation" EXACT []
is_a: GO:0046455 ! organosilicon catabolic process
is_a: GO:0046518 ! octamethylcyclotetrasiloxane metabolic process
is_a: GO:0046700 ! heterocycle catabolic process

[Term]
id: GO:0046518
name: octamethylcyclotetrasiloxane metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving octamethylcyclotetrasiloxane, a cyclic silicone-oxygen ring compound with two methyl groups attached to each silicone atom." [GOC:ai, http://chemfinder.cambridgesoft.com/]
subset: gosubset_prok
synonym: "octamethylcyclotetrasiloxane metabolism" EXACT []
is_a: GO:0018945 ! organosilicon metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0046519
name: sphingoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds." [ISBN:0198506732]
subset: gosubset_prok
synonym: "sphingoid base metabolic process" EXACT []
synonym: "sphingoid base metabolism" EXACT []
synonym: "sphingoid metabolism" EXACT []
is_a: GO:0006665 ! sphingolipid metabolic process

[Term]
id: GO:0046520
name: sphingoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds." [ISBN:0198506732]
subset: gosubset_prok
synonym: "sphingoid anabolism" EXACT []
synonym: "sphingoid biosynthesis" EXACT []
synonym: "sphingoid formation" EXACT []
synonym: "sphingoid synthesis" EXACT []
is_a: GO:0030148 ! sphingolipid biosynthetic process
is_a: GO:0046519 ! sphingoid metabolic process

[Term]
id: GO:0046521
name: sphingoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds." [ISBN:0198506732]
subset: gosubset_prok
synonym: "sphingoid breakdown" EXACT []
synonym: "sphingoid catabolism" EXACT []
synonym: "sphingoid degradation" EXACT []
is_a: GO:0030149 ! sphingolipid catabolic process
is_a: GO:0046519 ! sphingoid metabolic process

[Term]
id: GO:0046522
name: S-methyl-5-thioribose kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-methyl-5-thio-D-ribose + ATP = S-methyl-5-thio-alpha-D-ribose 1-phosphate + ADP + 2 H(+)." [EC:2.7.1.100, RHEA:22315]
subset: gosubset_prok
synonym: "5-methylthioribose kinase (phosphorylating)" EXACT [EC:2.7.1.100]
synonym: "5-methylthioribose kinase activity" EXACT []
synonym: "ATP:S-methyl-5-thio-D-ribose 1-phosphotransferase activity" EXACT [EC:2.7.1.100]
synonym: "ATP:S5-methyl-5-thio-D-ribose 1-phosphotransferase activity" EXACT [EC:2.7.1.100]
synonym: "methylthioribose kinase activity" EXACT [EC:2.7.1.100]
synonym: "MTR kinase activity" EXACT [EC:2.7.1.100]
xref: EC:2.7.1.100
xref: KEGG:R04143
xref: MetaCyc:5-METHYLTHIORIBOSE-KINASE-RXN
xref: RHEA:22315
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0046523
name: S-methyl-5-thioribose-1-phosphate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate." [EC:5.3.1.23, RHEA:19992]
subset: gosubset_prok
synonym: "1-phospho-5'-S-methylthioribose isomerase activity" EXACT [EC:5.3.1.23]
synonym: "1-PMTR isomerase activity" EXACT [EC:5.3.1.23]
synonym: "5-methylthio-5-deoxy-D-ribose-1-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.23]
synonym: "5-methylthioribose-1-phosphate isomerase activity" EXACT []
synonym: "methylthioribose 1-phosphate isomerase activity" EXACT [EC:5.3.1.23]
synonym: "MTR-1-P isomerase activity" EXACT [EC:5.3.1.23]
synonym: "S-methyl-5-thio-5-deoxy-D-ribose-1-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.23]
synonym: "S-methyl-5-thio-5-deoxy-D-ribose-1-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.23]
synonym: "S-methyl-5-thio-alpha-D-ribose-1-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.23]
synonym: "S-methyl-5-thio-D-ribose-1-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.23]
xref: EC:5.3.1.23
xref: KEGG:R04420
xref: MetaCyc:5.3.1.23-RXN
xref: Reactome:REACT_75840 "Methylthio-ribulose-P = Methylthio-ribose-P, Homo sapiens"
xref: Reactome:REACT_75853 "Methylthio-ribose-P = Methylthio-ribulose-P, Homo sapiens"
xref: RHEA:19992
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0046524
name: sucrose-phosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + D-fructose 6-phosphate = UDP + sucrose 6-phosphate." [EC:2.4.1.14]
subset: gosubset_prok
synonym: "SPS" RELATED [EC:2.4.1.14]
synonym: "sucrose 6-phosphate synthase activity" EXACT [EC:2.4.1.14]
synonym: "sucrose phosphate synthetase activity" EXACT [EC:2.4.1.14]
synonym: "sucrose phosphate-uridine diphosphate glucosyltransferase activity" EXACT [EC:2.4.1.14]
synonym: "sucrosephosphate-UDP glucosyltransferase activity" EXACT [EC:2.4.1.14]
synonym: "UDP-glucose-fructose-phosphate glucosyltransferase activity" EXACT [EC:2.4.1.14]
synonym: "UDP-glucose:D-fructose-6-phosphate 2-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.14]
synonym: "UDPglucose-fructose-phosphate glucosyltransferase activity" EXACT [EC:2.4.1.14]
synonym: "UDPglucose:D-fructose-6-phosphate 2-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.14]
synonym: "uridine diphosphoglucose-fructose phosphate glucosyltransferase activity" EXACT [EC:2.4.1.14]
xref: EC:2.4.1.14
xref: MetaCyc:SUCROSE-PHOSPHATE-SYNTHASE-RXN
xref: RHEA:22175
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0046525
name: xylosylprotein 4-beta-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-galactose + O-beta-D-xylosylprotein = UDP + 4-beta-D-galactosyl-O-beta-D-xylosylprotein." [EC:2.4.1.133]
synonym: "galactosyltransferase I activity" RELATED [EC:2.4.1.133]
synonym: "UDP-D-galactose:D-xylose galactosyltransferase activity" EXACT [EC:2.4.1.133]
synonym: "UDP-D-galactose:xylose galactosyltransferase activity" EXACT [EC:2.4.1.133]
synonym: "UDP-galactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.133]
synonym: "UDP-galactose:xylose galactosyltransferase activity" EXACT []
synonym: "UDPgalactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.133]
synonym: "uridine diphosphogalactose-xylose galactosyltransferase activity" EXACT [EC:2.4.1.133]
xref: EC:2.4.1.133
xref: MetaCyc:2.4.1.133-RXN
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0046526
name: D-xylulose reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(+) + xylitol = D-xylulose + H(+) + NADH." [EC:1.1.1.9, RHEA:20436]
subset: gosubset_prok
synonym: "xylitol dehydrogenase activity" EXACT [EC:1.1.1.9]
xref: EC:1.1.1.9
xref: KEGG:R01896
xref: MetaCyc:D-XYLULOSE-REDUCTASE-RXN
xref: RHEA:20436
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
is_a: GO:0031320 ! hexitol dehydrogenase activity

[Term]
id: GO:0046527
name: glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a glucosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [ISBN:0198506732]
subset: gosubset_prok
xref: EC:2.4.1.-
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0046528
name: imaginal disc fusion
namespace: biological_process
def: "The process following disc eversion whereby imaginal discs fuse with adjacent disc derivatives to form a continuous adult epidermis." [PMID:11494317]
is_a: GO:0009886 ! post-embryonic morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0007560 ! imaginal disc morphogenesis

[Term]
id: GO:0046529
name: imaginal disc fusion, thorax closure
namespace: biological_process
def: "The joining of the parts of the wing imaginal discs, giving rise to the adult thorax." [http://sdb.bio.purdue.edu/fly/gene/fos4.htm]
is_a: GO:0009886 ! post-embryonic morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0046528 ! imaginal disc fusion

[Term]
id: GO:0046530
name: photoreceptor cell differentiation
namespace: biological_process
alt_id: GO:0007467
def: "The specialization of organization of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. An example of this process is found in Drosophila melanogaster." [GOC:ai, ISBN:0198506732]
is_a: GO:0030182 ! neuron differentiation

[Term]
id: GO:0046532
name: regulation of photoreceptor cell differentiation
namespace: biological_process
alt_id: GO:0045673
def: "Any process that modulates the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster." [GOC:go_curators]
synonym: "regulation of photoreceptor differentiation" EXACT []
is_a: GO:0045664 ! regulation of neuron differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0046530 ! photoreceptor cell differentiation
relationship: regulates GO:0046530 ! photoreceptor cell differentiation

[Term]
id: GO:0046533
name: negative regulation of photoreceptor cell differentiation
namespace: biological_process
alt_id: GO:0045674
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster." [GOC:go_curators]
synonym: "down regulation of photoreceptor cell differentiation" EXACT []
synonym: "down regulation of photoreceptor differentiation" EXACT []
synonym: "down-regulation of photoreceptor cell differentiation" EXACT []
synonym: "down-regulation of photoreceptor differentiation" EXACT []
synonym: "downregulation of photoreceptor cell differentiation" EXACT []
synonym: "downregulation of photoreceptor differentiation" EXACT []
synonym: "inhibition of photoreceptor cell differentiation" NARROW []
synonym: "inhibition of photoreceptor differentiation" NARROW []
synonym: "negative regulation of photoreceptor differentiation" EXACT []
is_a: GO:0045665 ! negative regulation of neuron differentiation
is_a: GO:0046532 ! regulation of photoreceptor cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0046530 ! photoreceptor cell differentiation
relationship: negatively_regulates GO:0046530 ! photoreceptor cell differentiation

[Term]
id: GO:0046534
name: positive regulation of photoreceptor cell differentiation
namespace: biological_process
alt_id: GO:0045675
def: "Any process that activates or increases the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster." [GOC:go_curators]
synonym: "activation of photoreceptor cell differentiation" NARROW []
synonym: "activation of photoreceptor differentiation" NARROW []
synonym: "positive regulation of photoreceptor differentiation" EXACT []
synonym: "stimulation of photoreceptor cell differentiation" NARROW []
synonym: "stimulation of photoreceptor differentiation" NARROW []
synonym: "up regulation of photoreceptor cell differentiation" EXACT []
synonym: "up regulation of photoreceptor differentiation" EXACT []
synonym: "up-regulation of photoreceptor cell differentiation" EXACT []
synonym: "up-regulation of photoreceptor differentiation" EXACT []
synonym: "upregulation of photoreceptor cell differentiation" EXACT []
synonym: "upregulation of photoreceptor differentiation" EXACT []
is_a: GO:0045666 ! positive regulation of neuron differentiation
is_a: GO:0046532 ! regulation of photoreceptor cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0046530 ! photoreceptor cell differentiation
relationship: positively_regulates GO:0046530 ! photoreceptor cell differentiation

[Term]
id: GO:0046535
name: detection of chemical stimulus involved in sensory perception of umami taste
namespace: biological_process
def: "The series of events required for a umami taste stimulus to be received and converted to a molecular signal. Umami taste is the savory taste of meats and other foods that are rich in glutamates." [GOC:ai, GOC:dos, PMID:11894099]
synonym: "perception of umami taste, detection of chemical stimulus" EXACT []
synonym: "perception of umami taste, sensory transduction of chemical stimulus" EXACT []
synonym: "sensory detection of chemical stimulus during perception of umami taste" EXACT []
synonym: "sensory detection of umami taste" EXACT []
synonym: "sensory transduction of chemical stimulus during perception of umami taste" EXACT []
synonym: "sensory transduction of umami taste" EXACT []
synonym: "umami taste detection" EXACT []
is_a: GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste
intersection_of: GO:0009593 ! detection of chemical stimulus
intersection_of: part_of GO:0050917 ! sensory perception of umami taste
relationship: part_of GO:0050917 ! sensory perception of umami taste

[Term]
id: GO:0046536
name: dosage compensation complex
namespace: cellular_component
def: "A protein or protein-RNA complex that localizes to one or more of the sex chromosome(s), where it acts to normalize transcription between different sexes." [GOC:kmv, GOC:mah]
subset: goslim_pir
is_a: GO:0032991 ! macromolecular complex
is_a: GO:0044427 ! chromosomal part
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0000803 ! sex chromosome

[Term]
id: GO:0046537
name: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D glycerate; this reaction does not require the cofactor 2,3-bisphosphoglycerate." [EC:5.4.2.1]
subset: gosubset_prok
synonym: "PGAM-i" RELATED [EC:5.4.2.1]
is_a: GO:0004619 ! phosphoglycerate mutase activity

[Term]
id: GO:0046538
name: 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate; this reaction requires the cofactor 2,3-bisphosphoglycerate." [EC:5.4.2.1]
subset: gosubset_prok
synonym: "glycerate phosphomutase (diphosphoglycerate cofactor) activity" EXACT [EC:5.4.2.1]
synonym: "PGAM-d" RELATED [EC:5.4.2.1]
is_a: GO:0004619 ! phosphoglycerate mutase activity

[Term]
id: GO:0046539
name: histamine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + histamine = N(tau)-methylhistamine + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.8, RHEA:19304]
synonym: "histamine 1-methyltransferase activity" EXACT [EC:2.1.1.8]
synonym: "histamine methyltransferase activity" EXACT [EC:2.1.1.8]
synonym: "histamine-methylating enzyme" RELATED [EC:2.1.1.8]
synonym: "imidazolemethyltransferase activity" EXACT [EC:2.1.1.8]
synonym: "S-adenosyl-L-methionine:histamine N-tele-methyltransferase activity" EXACT [EC:2.1.1.8]
synonym: "S-adenosylmethionine-histamine N-methyltransferase activity" EXACT [EC:2.1.1.8]
xref: EC:2.1.1.8
xref: KEGG:R02155
xref: MetaCyc:HISTAMINE-N-METHYLTRANSFERASE-RXN
xref: RHEA:19304
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0046540
name: U4/U6 x U5 tri-snRNP complex
namespace: cellular_component
def: "A ribonucleoprotein complex formed by the association of the U4/U6 and U5 small nuclear ribonucleoproteins." [GOC:krc, GOC:pr, PMID:11867543]
synonym: "U4/U6.U5 snRNP complex" EXACT []
is_a: GO:0097526 ! spliceosomal tri-snRNP complex
relationship: has_part GO:0005682 ! U5 snRNP
relationship: has_part GO:0071001 ! U4/U6 snRNP

[Term]
id: GO:0046541
name: saliva secretion
namespace: biological_process
def: "The regulated release of saliva from the salivary glands. In man, the saliva is a turbid and slightly viscous fluid, generally of an alkaline reaction, and is secreted by the parotid, submaxillary, and sublingual glands. In the mouth the saliva is mixed with the secretion from the buccal glands. In man and many animals, saliva is an important digestive fluid on account of the presence of the peculiar enzyme, ptyalin." [GOC:curators, UBERON:0001836]
synonym: "salivation" EXACT []
xref: Wikipedia:Salivation
is_a: GO:0007589 ! body fluid secretion
is_a: GO:0022600 ! digestive system process
is_a: GO:0032941 ! secretion by tissue

[Term]
id: GO:0046542
name: obsolete alpha-factor export
namespace: biological_process
def: "OBSOLETE. The directed movement of alpha-factor, one of the two yeast mating factors, out of a cell." [GOC:ai]
comment: This term was made obsolete because it is a gene product based term and it does not involve a unique process.
synonym: "alpha-factor export" EXACT []
is_obsolete: true
consider: GO:0015833

[Term]
id: GO:0046543
name: development of secondary female sexual characteristics
namespace: biological_process
def: "The process whose specific outcome is the progression of the secondary female sexual characteristics over time, from their formation to the mature structures. In female humans, these include growth of axillary and pubic hair, breast development and menstrual periods. Their development occurs in response to sex hormone secretion." [GOC:ai]
is_a: GO:0045136 ! development of secondary sexual characteristics

[Term]
id: GO:0046544
name: development of secondary male sexual characteristics
namespace: biological_process
def: "The process whose specific outcome is the progression of the secondary male sexual characteristics over time, from their formation to the mature structures. In male humans, these include growth of axillary, chest, and pubic hair, voice changes, and testicular/penile enlargement. Development occurs in response to sex hormone secretion." [GOC:ai]
is_a: GO:0045136 ! development of secondary sexual characteristics
relationship: part_of GO:0046661 ! male sex differentiation

[Term]
id: GO:0046545
name: development of primary female sexual characteristics
namespace: biological_process
def: "The process whose specific outcome is the progression of the primary female sexual characteristics over time, from their formation to the mature structure. The primary female sexual characteristics are the ovaries, and they develop in response to sex hormone secretion." [GOC:ai]
is_a: GO:0045137 ! development of primary sexual characteristics
relationship: part_of GO:0046660 ! female sex differentiation

[Term]
id: GO:0046546
name: development of primary male sexual characteristics
namespace: biological_process
def: "The process whose specific outcome is the progression of the primary male sexual characteristics over time, from their formation to the mature structures. The primary male sexual characteristics are the testes, and they develop in response to sex hormone secretion." [GOC:ai]
is_a: GO:0045137 ! development of primary sexual characteristics
relationship: part_of GO:0046661 ! male sex differentiation

[Term]
id: GO:0046547
name: trans-aconitate 3-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + trans-aconitate = (E)-2-(methoxycarbonylmethyl)but-2-enedioate + S-adenosyl-L-homocysteine." [EC:2.1.1.145, RHEA:22203]
synonym: "S-adenosyl-L-methionine:(E)-prop-1-ene-1,2,3-tricarboxylate 3'-O-methyltransferase activity" EXACT [EC:2.1.1.145]
xref: EC:2.1.1.145
xref: KEGG:R05764
xref: MetaCyc:2.1.1.145-RXN
xref: RHEA:22203
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0046548
name: retinal rod cell development
namespace: biological_process
def: "Development of a rod cell, one of the sensory cells in the eye that reacts to the presence of light. Rod cells contain the photopigment rhodopsin or porphyropsin and are responsible for vision in dim light." [ISBN:0198506732]
is_a: GO:0042462 ! eye photoreceptor cell development

[Term]
id: GO:0046549
name: retinal cone cell development
namespace: biological_process
def: "Development of a cone cell, one of the sensory cells in the eye that reacts to the presence of light. Cone cells contain the photopigment iodopsin or cyanopsin and are responsible for photopic (daylight) vision." [ISBN:0198506732]
is_a: GO:0042462 ! eye photoreceptor cell development
relationship: part_of GO:0042670 ! retinal cone cell differentiation

[Term]
id: GO:0046550
name: (3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine biosynthetic process from asparagine
namespace: biological_process
def: "The modification of asparagine to (3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine as found in microcin C7 produced from the mccA gene in E. coli plasmid pMccC7." [RESID:AA0328]
subset: gosubset_prok
synonym: "(3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine anabolism from asparagine" EXACT []
synonym: "(3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine formation from asparagine" EXACT []
synonym: "(3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine synthesis from asparagine" EXACT []
xref: RESID:AA0328
is_a: GO:0006528 ! asparagine metabolic process
is_a: GO:0009165 ! nucleotide biosynthetic process
is_a: GO:0018196 ! peptidyl-asparagine modification
is_a: GO:0042398 ! cellular modified amino acid biosynthetic process

[Term]
id: GO:0046551
name: retinal cone cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal cone cell. A retinal cone cell is one of the two photoreceptor subtypes in a camera-type eye." [GOC:mtg_sensu, PMID:3076112, PMID:3937883]
is_a: GO:0060220 ! camera-type eye photoreceptor cell fate commitment
relationship: part_of GO:0042670 ! retinal cone cell differentiation

[Term]
id: GO:0046552
name: photoreceptor cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments." [GOC:mtg_sensu]
is_a: GO:0048663 ! neuron fate commitment
relationship: part_of GO:0046530 ! photoreceptor cell differentiation

[Term]
id: GO:0046553
name: D-malate dehydrogenase (decarboxylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-malate + NAD(+) = CO(2) + NADH + pyruvate." [EC:1.1.1.83, RHEA:18368]
synonym: "(R)-malate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.83]
synonym: "bifunctional L(+)-tartrate dehydrogenase-D(+)-malate (decarboxylating)" RELATED [EC:1.1.1.83]
synonym: "D-malate dehydrogenase activity" EXACT [EC:1.1.1.83]
synonym: "D-malic enzyme" RELATED [EC:1.1.1.83]
xref: EC:1.1.1.83
xref: KEGG:R00215
xref: MetaCyc:1.1.1.83-RXN
xref: RHEA:18368
is_a: GO:0016615 ! malate dehydrogenase activity
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0046554
name: malate dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-malate + NADP+ = oxaloacetate + NADPH + H+." [EC:1.1.1.82]
subset: gosubset_prok
synonym: "(S)-malate:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.82, KEGG:R00343]
synonym: "malate NADP dehydrogenase activity" EXACT [EC:1.1.1.82]
synonym: "malic dehydrogenase (nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.1.1.82]
synonym: "NADP malate dehydrogenase activity" EXACT [EC:1.1.1.82]
synonym: "NADP-linked malate dehydrogenase activity" EXACT [EC:1.1.1.82]
synonym: "NADP-malate dehydrogenase activity" EXACT [EC:1.1.1.82]
xref: EC:1.1.1.82
xref: KEGG:R00343
xref: MetaCyc:MALATE-DEHYDROGENASE-NADP+-RXN
xref: RHEA:10827
is_a: GO:0016615 ! malate dehydrogenase activity
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0046555
name: acetylxylan esterase activity
namespace: molecular_function
def: "Catalysis of the deacetylation of xylans and xylo-oligosaccharides." [EC:3.1.1.72]
subset: gosubset_prok
xref: EC:3.1.1.72
xref: MetaCyc:3.1.1.72-RXN
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0046556
name: alpha-L-arabinofuranosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides." [EC:3.2.1.55, GOC:mf]
subset: gosubset_prok
synonym: "alpha-arabinofuranosidase activity" EXACT [EC:3.2.1.55]
synonym: "alpha-arabinosidase activity" EXACT [EC:3.2.1.55]
synonym: "alpha-L-arabinanase activity" EXACT [EC:3.2.1.55]
synonym: "alpha-L-arabinofuranoside arabinofuranohydrolase activity" EXACT [EC:3.2.1.55]
synonym: "alpha-L-arabinofuranoside hydrolase activity" EXACT [EC:3.2.1.55]
synonym: "alpha-L-arabinosidase activity" EXACT [EC:3.2.1.55]
synonym: "alpha-N-arabinofuranosidase activity" RELATED []
synonym: "arabinofuranosidase activity" EXACT [EC:3.2.1.55]
synonym: "arabinosidase activity" EXACT [EC:3.2.1.55]
synonym: "L-arabinosidase activity" EXACT [EC:3.2.1.55]
synonym: "polysaccharide alpha-L-arabinofuranosidase activity" EXACT []
xref: EC:3.2.1.55
xref: MetaCyc:3.2.1.55-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0046557
name: glucan endo-1,6-beta-glucosidase activity
namespace: molecular_function
def: "Catalysis of the random hydrolysis of (1->6) linkages in (1->6)-beta-D-glucans." [EC:3.2.1.75]
synonym: "1,6-beta-D-glucan glucanohydrolase activity" EXACT [EC:3.2.1.75]
synonym: "beta-1,6-glucan 6-glucanohydrolase activity" EXACT [EC:3.2.1.75]
synonym: "beta-1,6-glucan hydrolase activity" EXACT [EC:3.2.1.75]
synonym: "beta-1,6-glucanase activity" EXACT [EC:3.2.1.75]
synonym: "beta-1,6-glucanase-pustulanase activity" EXACT [EC:3.2.1.75]
synonym: "beta-1->6-glucan hydrolase activity" EXACT [EC:3.2.1.75]
synonym: "endo-(1,6)-beta-D-glucanase activity" EXACT []
synonym: "endo-(1->6)-beta-D-glucanase activity" EXACT [EC:3.2.1.75]
synonym: "endo-1,6-beta-D-glucanase activity" EXACT [EC:3.2.1.75]
synonym: "endo-1,6-beta-glucanase activity" EXACT [EC:3.2.1.75]
synonym: "endo-beta-1,6-glucanase activity" EXACT [EC:3.2.1.75]
xref: EC:3.2.1.75
xref: MetaCyc:3.2.1.75-RXN
is_a: GO:0008422 ! beta-glucosidase activity

[Term]
id: GO:0046558
name: arabinan endo-1,5-alpha-L-arabinosidase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of (1->5)-alpha-arabinofuranosidic linkages in (1->5) arabinans." [EC:3.2.1.99]
subset: gosubset_prok
synonym: "1,5-alpha-L-arabinan 1,5-alpha-L-arabinanohydrolase activity" EXACT [EC:3.2.1.99]
synonym: "endo-1,5-alpha-L-arabinanase activity" EXACT [EC:3.2.1.99]
synonym: "endo-alpha-1,5-arabanase activity" EXACT [EC:3.2.1.99]
synonym: "endo-arabanase activity" EXACT [EC:3.2.1.99]
xref: EC:3.2.1.99
xref: MetaCyc:3.2.1.99-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0046559
name: alpha-glucuronidase activity
namespace: molecular_function
def: "Catalysis of the reaction: an alpha-D-glucuronoside + H2O = an alcohol + D-glucuronate." [EC:3.2.1.139]
subset: gosubset_prok
synonym: "alpha-D-glucosiduronate glucuronohydrolase activity" EXACT [EC:3.2.1.139]
synonym: "alpha-glucosiduronase activity" EXACT [EC:3.2.1.139]
xref: EC:3.2.1.139
xref: MetaCyc:3.2.1.139-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0046560
name: obsolete scytalidopepsin B activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity, cleaving Phe24-Phe, but not Leu15-Tyr and Phe25-Tyr in the B chain of insulin." [EC:3.4.23.32]
comment: This term was made obsolete because it represents a gene product.
synonym: "Ganoderma lucidum aspartic proteinase activity" EXACT [EC:3.4.23.32]
synonym: "Ganoderma lucidum carboxyl proteinase activity" EXACT [EC:3.4.23.32]
synonym: "Scytalidium aspartic proteinase B activity" RELATED [EC:3.4.23.32]
synonym: "Scytalidium lignicolum aspartic proteinase B" RELATED [EC:3.4.23.32]
synonym: "scytalidopepsin B activity" EXACT []
synonym: "SLB" RELATED [EC:3.4.23.32]
xref: EC:3.4.23.32
xref: MetaCyc:3.4.23.32-RXN
is_obsolete: true
replaced_by: GO:0004190

[Term]
id: GO:0046561
name: obsolete penicillopepsin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1', but also cleaving Gly20-Glu in the B chain of insulin. Clots milk, and activates trypsinogen." [EC:3.4.23.20]
comment: This term was made obsolete because it represents a gene product.
synonym: "acid protease A" EXACT []
synonym: "Penicillium aspartic proteinase activity" EXACT [EC:3.4.23.20]
synonym: "Penicillium caseicolum aspartic proteinase activity" EXACT [EC:3.4.23.20]
synonym: "Penicillium citrinum acid proteinase activity" EXACT [EC:3.4.23.20]
synonym: "Penicillium citrinum aspartic proteinase activity" EXACT [EC:3.4.23.20]
synonym: "Penicillium cyclopium acid proteinase activity" EXACT [EC:3.4.23.20]
synonym: "Penicillium duponti aspartic proteinase activity" EXACT [EC:3.4.23.20]
synonym: "Penicillium expansum acid proteinase activity" EXACT [EC:3.4.23.20]
synonym: "Penicillium expansum aspartic proteinase activity" EXACT [EC:3.4.23.20]
synonym: "Penicillium janthinellum acid proteinase activity" EXACT [EC:3.4.23.20]
synonym: "Penicillium janthinellum aspartic protease activity" EXACT [EC:3.4.23.20]
synonym: "Penicillium janthinellum aspartic proteinase activity" EXACT [EC:3.4.23.20]
synonym: "Penicillium roqueforti acid proteinase activity" EXACT [EC:3.4.23.20]
synonym: "penicillopepsin activity" EXACT []
synonym: "peptidase A activity" BROAD [EC:3.4.23.20]
xref: EC:3.4.23.20
xref: MetaCyc:3.4.23.20-RXN
is_obsolete: true
replaced_by: GO:0004190

[Term]
id: GO:0046562
name: glucose oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-D-glucose + O2 = D-glucono-1,5-lactone + H2O2." [EC:1.1.3.4, GOC:mah]
synonym: "beta-D-glucose oxidase activity" EXACT []
synonym: "beta-D-glucose:oxygen 1-oxido-reductase activity" EXACT [EC:1.1.3.4]
synonym: "beta-D-glucose:oxygen 1-oxidoreductase activity" EXACT [EC:1.1.3.4]
synonym: "beta-D-glucose:quinone oxidoreductase activity" EXACT [EC:1.1.3.4]
synonym: "corylophyline" RELATED [EC:1.1.3.4]
synonym: "D-glucose oxidase activity" EXACT [EC:1.1.3.4]
synonym: "D-glucose-1-oxidase activity" EXACT [EC:1.1.3.4]
synonym: "deoxin-1" RELATED [EC:1.1.3.4]
synonym: "glucose aerodehydrogenase activity" EXACT [EC:1.1.3.4]
synonym: "glucose oxyhydrase activity" EXACT [EC:1.1.3.4]
synonym: "GOD activity" RELATED [EC:1.1.3.4]
synonym: "microcid" RELATED [EC:1.1.3.4]
synonym: "penatin" RELATED [EC:1.1.3.4]
xref: EC:1.1.3.4
xref: KEGG:R01522
xref: MetaCyc:GLUCOSE-OXIDASE-RXN
xref: RHEA:11431
is_a: GO:0047979 ! hexose oxidase activity

[Term]
id: GO:0046563
name: methanol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + methanol = H2O2 + formaldehyde." [MetaCyc:METHANOL-OXIDASE-RXN]
comment: Note that EC:1.1.3.31 was deleted from EC as it cannot be distinguished from alcohol oxidase (EC:1.1.3.13).
xref: EC:1.1.3.-
xref: MetaCyc:METHANOL-OXIDASE-RXN
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0046564
name: oxalate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(+) + oxalate = CO(2) + formate." [EC:4.1.1.2, RHEA:16512]
subset: gosubset_prok
synonym: "oxalate carboxy-lyase (formate-forming)" EXACT [EC:4.1.1.2]
synonym: "oxalate carboxy-lyase activity" EXACT [EC:4.1.1.2]
xref: EC:4.1.1.2
xref: KEGG:R00522
xref: MetaCyc:OXALATE-DECARBOXYLASE-RXN
xref: RHEA:16512
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0046565
name: 3-dehydroshikimate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-dehydroshikimate = 3,4-dihydroxybenzoate + H2O. 3,4-dihydroxybenzoate is also known as protocatechuate." [EC:4.2.1.-, MetaCyc:DHSHIKIMATE-DEHYDRO-RXN]
xref: EC:4.2.1.-
xref: MetaCyc:DHSHIKIMATE-DEHYDRO-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0046566
name: DOPA dioxygenase activity
namespace: molecular_function
def: "Catalysis of the 4,5-ring opening reaction: 3,4-dihydroxyphenylalanine + O2 = 4,5-seco-DOPA. 4,5-seco-DOPA spontaneously recyclizes to form betalamic acid." [PMID:11711071]
synonym: "dihydroxyphenylalanine dioxygenase activity" EXACT []
xref: MetaCyc:RXN-8460
is_a: GO:0051213 ! dioxygenase activity

[Term]
id: GO:0046567
name: aphidicolan-16 beta-ol synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 9-alpha-copalyl diphosphate + H2O = aphidicolan-16-beta-ol + diphosphate." [EC:4.2.3.42, PMID:12149019]
synonym: "9-alpha-copalyl-diphosphate diphosphate-lyase (aphidicolan-16-beta-ol-forming)" EXACT [EC:4.2.3.42]
xref: EC:4.2.3.42
xref: KEGG:R06313
xref: MetaCyc:RXN-10631
xref: RHEA:26216
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0046568
name: 3-methylbutanol:NAD(P) oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-methylbutanol + NAD(P)+ = 3-methylbutanal + NAD(P)H + H+. 3-methylbutanal is also known as isovaleraldehyde." [EC:1.1.1.265]
synonym: "3-methylbutanal reductase [NAD(P)] activity" EXACT [EC:1.1.1.265]
synonym: "3-methylbutyraldehyde reductase activity" EXACT []
synonym: "isoamyl alcohol oxidase activity" EXACT []
xref: EC:1.1.1.265
xref: MetaCyc:1.1.1.265-RXN
is_a: GO:0018455 ! alcohol dehydrogenase [NAD(P)+] activity

[Term]
id: GO:0046569
name: glyoxal oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: glyoxal + O2 + H2O = glyoxalate + H2O2." [EC:1.2.3.-, PMID:11733005]
synonym: "GLOX" EXACT []
xref: EC:1.2.3.-
is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor

[Term]
id: GO:0046570
name: methylthioribulose 1-phosphate dehydratase activity
namespace: molecular_function
alt_id: GO:0043809
def: "Catalysis of the reaction: S-methyl-5-thio-D-ribulose 1-phosphate = 5-(methylthio)-2,3-dioxopentyl phosphate + H(2)O." [EC:4.2.1.109, RHEA:15552]
synonym: "1-PMT-ribulose dehydratase activity" EXACT [EC:4.2.1.109]
synonym: "5-methylthioribulose-1-phosphate 4-dehydratase activity" EXACT [MetaCyc:R145-RXN]
synonym: "methylthioribulose-1-phosphate dehydratase activity" EXACT []
synonym: "S-methyl-5-thio-D-ribulose-1-phosphate hydro-lyase [5-(methylthio)-2,3-dioxopentyl-phosphate-forming]" RELATED [EC:4.2.1.109]
synonym: "S-methyl-5-thio-D-ribulose-1-phosphate hydro-lyase activity" EXACT []
synonym: "S-methyl-5-thio-D-ribulose-1-phosphate hydro-lyase[5-(methylthio)-2,3-dioxopentyl-phosphate-forming]" EXACT []
xref: EC:4.2.1.109
xref: KEGG:R07392
xref: MetaCyc:R145-RXN
xref: Reactome:REACT_75828 "Dehydration of methylthio-ribulose-P, Homo sapiens"
xref: RHEA:15552
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0046571
name: aspartate-2-keto-4-methylthiobutyrate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-keto-4-methylthiobutyrate + aspartate = methionine + oxaloacetate." [MetaCyc:R15-RXN]
xref: EC:2.6.1.-
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0046572
name: versicolorin B synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: versiconal = versicolorin B + H2O." [MetaCyc:RXN-9494, PMID:8784203]
xref: MetaCyc:RXN-9494
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0046573
name: lactonohydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of lactone rings (intramolecular cyclic esters) to produce a hydroxyl group and a carboxyl group." [PMID:11640988]
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0046574
name: glycuronidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of glucuronosides, yielding free glucuronic acid." [PMID:10441389, PMID:12044176]
synonym: "glucuronyl hydrolase activity" EXACT []
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0046575
name: rhamnogalacturonan acetylesterase activity
namespace: molecular_function
def: "Catalysis of the removal of acetylesters (as acetate) from galacturonic acid residues in the backbone of rhamnogalacturonan." [PMID:10801485]
is_a: GO:0008126 ! acetylesterase activity

[Term]
id: GO:0046576
name: rhamnogalacturonan alpha-L-rhamnopyranosyl-(1->4)-alpha-D-galactopyranosyluronide lyase activity
namespace: molecular_function
def: "Catalysis of the cleavage of rhamnogalacturonan, generating oligosaccharides of the form alpha-D-us-galacturonic acid-(1,2)-alpha-L-rhamnose-(1,4)-alpha-D-galacturonate-(1,2)-L-rhamnose-(1,2)-alpha-L-rhamnose-p-(1,4)-alpha-D-galacturonic acid, terminating at the non-reducing end with a hex-4-enopyranosyluronic acid residue." [PMID:8587995, PMID:8720076]
synonym: "rhamnogalacturonase B activity" EXACT [PMID:8587995]
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0046577
name: long-chain-alcohol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 long-chain alcohol + O2 = 2 long-chain aldehyde + 2 H2O." [EC:1.1.3.20]
synonym: "fatty alcohol oxidase activity" EXACT []
synonym: "fatty alcohol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.20]
synonym: "long-chain fatty acid oxidase activity" EXACT [EC:1.1.3.20]
synonym: "long-chain fatty alcohol oxidase activity" EXACT []
synonym: "long-chain-alcohol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.20]
xref: EC:1.1.3.20
xref: MetaCyc:LONG-CHAIN-ALCOHOL-OXIDASE-RXN
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0046578
name: regulation of Ras protein signal transduction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Ras protein signal transduction." [GOC:bf]
is_a: GO:0051056 ! regulation of small GTPase mediated signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007265 ! Ras protein signal transduction
relationship: regulates GO:0007265 ! Ras protein signal transduction

[Term]
id: GO:0046579
name: positive regulation of Ras protein signal transduction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of Ras protein signal transduction." [GOC:bf]
synonym: "activation of Ras protein signal transduction" NARROW []
synonym: "stimulation of Ras protein signal transduction" NARROW []
synonym: "up regulation of Ras protein signal transduction" EXACT []
synonym: "up-regulation of Ras protein signal transduction" EXACT []
synonym: "upregulation of Ras protein signal transduction" EXACT []
is_a: GO:0046578 ! regulation of Ras protein signal transduction
is_a: GO:0051057 ! positive regulation of small GTPase mediated signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007265 ! Ras protein signal transduction
relationship: positively_regulates GO:0007265 ! Ras protein signal transduction

[Term]
id: GO:0046580
name: negative regulation of Ras protein signal transduction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction." [GOC:bf]
synonym: "down regulation of Ras protein signal transduction" EXACT []
synonym: "down-regulation of Ras protein signal transduction" EXACT []
synonym: "downregulation of Ras protein signal transduction" EXACT []
synonym: "inhibition of Ras protein signal transduction" NARROW []
is_a: GO:0046578 ! regulation of Ras protein signal transduction
is_a: GO:0051058 ! negative regulation of small GTPase mediated signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007265 ! Ras protein signal transduction
relationship: negatively_regulates GO:0007265 ! Ras protein signal transduction

[Term]
id: GO:0046581
name: intercellular canaliculus
namespace: cellular_component
def: "An extremely narrow tubular channel located between adjacent cells. An instance of this is the secretory canaliculi occurring between adjacent parietal cells in the gastric mucosa of vertebrates." [ISBN:0721662544]
is_a: GO:0005911 ! cell-cell junction

[Term]
id: GO:0046583
name: cation efflux transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a cation or cations from the inside of the cell to the outside of the cell across a membrane." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "cation efflux permease activity" EXACT []
is_a: GO:0008324 ! cation transmembrane transporter activity
is_a: GO:0015562 ! efflux transmembrane transporter activity

[Term]
id: GO:0046584
name: enniatin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving enniatins, any of various cyclodepsipeptide antibiotics from Fusarium species that function as ionophores." [ISBN:0198506732]
subset: gosubset_prok
synonym: "enniatin metabolism" EXACT []
is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0050761 ! depsipeptide metabolic process
is_a: GO:1901334 ! lactone metabolic process

[Term]
id: GO:0046585
name: enniatin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of enniatins, any of various cyclodepsipeptide antibiotics from Fusarium species that function as ionophores." [ISBN:0198506732]
subset: gosubset_prok
synonym: "enniatin anabolism" EXACT []
synonym: "enniatin biosynthesis" EXACT []
synonym: "enniatin formation" EXACT []
synonym: "enniatin synthesis" EXACT []
is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0046584 ! enniatin metabolic process
is_a: GO:0050763 ! depsipeptide biosynthetic process
is_a: GO:1901336 ! lactone biosynthetic process

[Term]
id: GO:0046586
name: regulation of calcium-dependent cell-cell adhesion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction." [GOC:ai]
is_a: GO:0022407 ! regulation of cell-cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016339 ! calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
relationship: regulates GO:0016339 ! calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules

[Term]
id: GO:0046587
name: positive regulation of calcium-dependent cell-cell adhesion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of calcium-dependent cell-cell adhesion." [GOC:ai]
synonym: "activation of calcium-dependent cell-cell adhesion" NARROW []
synonym: "stimulation of calcium-dependent cell-cell adhesion" NARROW []
synonym: "up regulation of calcium-dependent cell-cell adhesion" EXACT []
synonym: "up-regulation of calcium-dependent cell-cell adhesion" EXACT []
synonym: "upregulation of calcium-dependent cell-cell adhesion" EXACT []
is_a: GO:0022409 ! positive regulation of cell-cell adhesion
is_a: GO:0046586 ! regulation of calcium-dependent cell-cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016339 ! calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
relationship: positively_regulates GO:0016339 ! calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules

[Term]
id: GO:0046588
name: negative regulation of calcium-dependent cell-cell adhesion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of calcium-dependent cell-cell adhesion." [GOC:ai]
synonym: "down regulation of calcium-dependent cell-cell adhesion" EXACT []
synonym: "down-regulation of calcium-dependent cell-cell adhesion" EXACT []
synonym: "downregulation of calcium-dependent cell-cell adhesion" EXACT []
synonym: "inhibition of calcium-dependent cell-cell adhesion" NARROW []
is_a: GO:0022408 ! negative regulation of cell-cell adhesion
is_a: GO:0046586 ! regulation of calcium-dependent cell-cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016339 ! calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
relationship: negatively_regulates GO:0016339 ! calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules

[Term]
id: GO:0046589
name: ribonuclease T1 activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in Gp with 2',3'-cyclic phosphate intermediates." [EC:3.1.27.3]
subset: gosubset_prok
synonym: "Aspergillus oryzae ribonuclease activity" NARROW [EC:3.1.27.3]
synonym: "binase activity" EXACT [EC:3.1.27.3]
synonym: "guanyl-specific RNase activity" EXACT [EC:3.1.27.3]
synonym: "guanyloribonuclease activity" EXACT [EC:3.1.27.3]
synonym: "ribonuclease C2" RELATED [EC:3.1.27.3]
synonym: "ribonuclease Ch" RELATED [EC:3.1.27.3]
synonym: "ribonuclease F1" EXACT []
synonym: "ribonuclease guaninenucleotido-2'-transferase (cyclizing)" EXACT [EC:3.1.27.3]
synonym: "ribonuclease N1" RELATED [EC:3.1.27.3]
synonym: "ribonuclease N3" RELATED [EC:3.1.27.3]
synonym: "ribonuclease PP1" RELATED [EC:3.1.27.3]
synonym: "ribonuclease SA" RELATED [EC:3.1.27.3]
synonym: "ribonuclease U1" RELATED [EC:3.1.27.3]
synonym: "RNase F1" RELATED [EC:3.1.27.3]
synonym: "RNase G" RELATED [EC:3.1.27.3]
synonym: "RNase N1 activity" EXACT [EC:3.1.27.3]
synonym: "RNase N2 activity" EXACT [EC:3.1.27.3]
synonym: "RNase Sa" RELATED [EC:3.1.27.3]
synonym: "RNase T1" RELATED [EC:3.1.27.3]
synonym: "RNase T1 activity" EXACT []
xref: EC:3.1.27.3
xref: MetaCyc:3.1.27.3-RXN
is_a: GO:0004540 ! ribonuclease activity

[Term]
id: GO:0046590
name: obsolete embryonic leg morphogenesis
namespace: biological_process
def: "OBSOLETE. The process, occurring in the embryo, by which the anatomical structures of the leg are generated and organized. A leg is a limb on which an animal walks and stands." [GOC:bf]
comment: This term was made obsolete because leg is a mechano-functional grouping, and having both 'leg morphogenesis' and 'hindlimb morphogenesis' terms causes errors in querying.
synonym: "embryonic leg morphogenesis" EXACT []
is_obsolete: true
consider: GO:0030326
consider: GO:0035116

[Term]
id: GO:0046591
name: obsolete embryonic leg joint morphogenesis
namespace: biological_process
def: "OBSOLETE. The process, occurring in the embryo, by which the anatomical structures of the leg joint are generated and organized. A leg joint is a flexible region that separates the rigid sections of a leg to allow movement in a controlled manner." [GOC:bf, ISBN:0582227089, PMID:12051824]
comment: This term was made obsolete because leg is a mechano-functional grouping, and having both 'leg morphogenesis' and 'hindlimb morphogenesis' terms causes errors in querying.
synonym: "embryonic leg joint morphogenesis" EXACT []
is_obsolete: true
consider: GO:0036023

[Term]
id: GO:0046592
name: polyamine oxidase activity
namespace: molecular_function
def: "Catalysis of the oxidative degradation or interconversion of polyamines." [EC:1.5.3.11, PMID:1567380]
comment: This term represents a deleted EC activity and is scheduled for obsoletion.
subset: mf_needs_review
synonym: "1-N-acetylspermidine:oxygen oxidoreductase (deaminating)" NARROW [EC:1.5.3.11]
synonym: "N1-acetylspermidine:oxygen oxidoreductase (deaminating)" NARROW [EC:1.5.3.11]
xref: EC:1.5.3.11
xref: MetaCyc:POLYAMINE-OXIDASE-RXN
xref: Reactome:REACT_100725 "Spermine is oxidized to spermidine, Xenopus tropicalis"
xref: Reactome:REACT_102677 "N-acetylspermidine is oxidized to putrescine, Xenopus tropicalis"
xref: Reactome:REACT_102996 "Spermine is oxidized to spermidine, Danio rerio"
xref: Reactome:REACT_103785 "N-acetylspermidine is oxidized to putrescine, Oryza sativa"
xref: Reactome:REACT_104101 "Spermine is oxidized to spermidine, Taeniopygia guttata"
xref: Reactome:REACT_104252 "N-acetylspermine is oxidised to spermidine, Taeniopygia guttata"
xref: Reactome:REACT_104278 "N-acetylspermidine is oxidized to putrescine, Mus musculus"
xref: Reactome:REACT_104635 "N-acetylspermine is oxidised to spermidine, Gallus gallus"
xref: Reactome:REACT_106376 "N-acetylspermine is oxidised to spermidine, Canis familiaris"
xref: Reactome:REACT_107167 "N-acetylspermidine is oxidized to putrescine, Arabidopsis thaliana"
xref: Reactome:REACT_108826 "N-acetylspermine is oxidised to spermidine, Saccharomyces cerevisiae"
xref: Reactome:REACT_112199 "N-acetylspermidine is oxidized to putrescine, Drosophila melanogaster"
xref: Reactome:REACT_112853 "N-acetylspermine is oxidised to spermidine, Drosophila melanogaster"
xref: Reactome:REACT_114114 "Spermine is oxidized to spermidine, Caenorhabditis elegans"
xref: Reactome:REACT_114150 "Spermine is oxidized to spermidine, Drosophila melanogaster"
xref: Reactome:REACT_114231 "N-acetylspermine is oxidised to spermidine, Caenorhabditis elegans"
xref: Reactome:REACT_114621 "N-acetylspermidine is oxidized to putrescine, Caenorhabditis elegans"
xref: Reactome:REACT_1548 "N-acetylspermidine is oxidized to putrescine, Homo sapiens"
xref: Reactome:REACT_2194 "Spermine is oxidized to spermidine, Homo sapiens"
xref: Reactome:REACT_2231 "N-acetylspermine is oxidised to spermidine, Homo sapiens"
xref: Reactome:REACT_28547 "N-acetylspermine is oxidised to spermidine, Arabidopsis thaliana"
xref: Reactome:REACT_31491 "N-acetylspermidine is oxidized to putrescine, Taeniopygia guttata"
xref: Reactome:REACT_32103 "N-acetylspermine is oxidised to spermidine, Rattus norvegicus"
xref: Reactome:REACT_33308 "Spermine is oxidized to spermidine, Canis familiaris"
xref: Reactome:REACT_33628 "N-acetylspermine is oxidised to spermidine, Bos taurus"
xref: Reactome:REACT_34337 "Spermine is oxidized to spermidine, Sus scrofa"
xref: Reactome:REACT_77844 "Spermine is oxidized to spermidine, Gallus gallus"
xref: Reactome:REACT_78001 "N-acetylspermidine is oxidized to putrescine, Saccharomyces cerevisiae"
xref: Reactome:REACT_79419 "Spermine is oxidized to spermidine, Mus musculus"
xref: Reactome:REACT_80358 "N-acetylspermidine is oxidized to putrescine, Danio rerio"
xref: Reactome:REACT_81220 "N-acetylspermidine is oxidized to putrescine, Bos taurus"
xref: Reactome:REACT_81986 "N-acetylspermidine is oxidized to putrescine, Canis familiaris"
xref: Reactome:REACT_84150 "N-acetylspermine is oxidised to spermidine, Mus musculus"
xref: Reactome:REACT_84367 "N-acetylspermine is oxidised to spermidine, Xenopus tropicalis"
xref: Reactome:REACT_84703 "Spermine is oxidized to spermidine, Saccharomyces cerevisiae"
xref: Reactome:REACT_85293 "Spermine is oxidized to spermidine, Bos taurus"
xref: Reactome:REACT_86408 "N-acetylspermine is oxidised to spermidine, Oryza sativa"
xref: Reactome:REACT_92172 "Spermine is oxidized to spermidine, Oryza sativa"
xref: Reactome:REACT_93069 "Spermine is oxidized to spermidine, Arabidopsis thaliana"
xref: Reactome:REACT_94623 "Spermine is oxidized to spermidine, Rattus norvegicus"
xref: Reactome:REACT_95871 "N-acetylspermine is oxidised to spermidine, Danio rerio"
xref: Reactome:REACT_98699 "N-acetylspermidine is oxidized to putrescine, Gallus gallus"
xref: Reactome:REACT_99634 "N-acetylspermidine is oxidized to putrescine, Rattus norvegicus"
is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor

[Term]
id: GO:0046593
name: mandelonitrile lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: mandelonitrile = cyanide + benzaldehyde." [EC:4.1.2.10]
synonym: "(R)-oxynitrilase activity" EXACT [EC:4.1.2.10]
synonym: "D-alpha-hydroxynitrile lyase activity" EXACT [EC:4.1.2.10]
synonym: "D-oxynitrilase activity" EXACT [EC:4.1.2.10]
synonym: "hydroxynitrile lyase activity" BROAD []
synonym: "mandelonitrile benzaldehyde-lyase (cyanide-forming)" EXACT [EC:4.1.2.10]
synonym: "mandelonitrile benzaldehyde-lyase activity" EXACT [EC:4.1.2.10]
xref: EC:4.1.2.10
xref: MetaCyc:MANDELONITRILE-LYASE-RXN
xref: RHEA:18316
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0046594
name: maintenance of pole plasm mRNA location
namespace: biological_process
alt_id: GO:0048122
def: "The process of maintaining mRNA in a specific location in the oocyte pole plasm. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:dph, GOC:tb]
synonym: "maintenance of oocyte pole plasm mRNA localization" EXACT []
synonym: "maintenance of pole plasm mRNA localization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0051237 ! maintenance of RNA location
is_a: GO:0051651 ! maintenance of location in cell
relationship: part_of GO:0019094 ! pole plasm mRNA localization

[Term]
id: GO:0046595
name: establishment of pole plasm mRNA localization
namespace: biological_process
alt_id: GO:0048121
def: "Any process that results in the directed movement of mRNA to the oocyte pole plasm." [GOC:bf]
synonym: "establishment of oocyte pole plasm mRNA localization" EXACT []
synonym: "establishment of pole plasm mRNA localisation" EXACT [GOC:mah]
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0051236 ! establishment of RNA localization
is_a: GO:1902578 ! single-organism localization
relationship: part_of GO:0019094 ! pole plasm mRNA localization

[Term]
id: GO:0046596
name: regulation of viral entry into host cell
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the viral entry into the host cell." [GOC:jl]
synonym: "regulation of viral penetration into host cell" EXACT []
synonym: "viral escort protein" RELATED [GOC:bm]
is_a: GO:0040012 ! regulation of locomotion
is_a: GO:1903900 ! regulation of viral life cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0046718 ! viral entry into host cell
relationship: regulates GO:0046718 ! viral entry into host cell

[Term]
id: GO:0046597
name: negative regulation of viral entry into host cell
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the entry of viral entry into a host cell." [GOC:jl]
synonym: "negative regulation of viral penetration into host cell" EXACT []
is_a: GO:0040013 ! negative regulation of locomotion
is_a: GO:0046596 ! regulation of viral entry into host cell
is_a: GO:1903901 ! negative regulation of viral life cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0046718 ! viral entry into host cell
relationship: negatively_regulates GO:0046718 ! viral entry into host cell

[Term]
id: GO:0046598
name: positive regulation of viral entry into host cell
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the introduction of viral entry into the host cell." [GOC:jl]
synonym: "positive regulation of viral penetration into host cell" EXACT []
is_a: GO:0040017 ! positive regulation of locomotion
is_a: GO:0046596 ! regulation of viral entry into host cell
is_a: GO:1903902 ! positive regulation of viral life cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0046718 ! viral entry into host cell
relationship: positively_regulates GO:0046718 ! viral entry into host cell

[Term]
id: GO:0046599
name: regulation of centriole replication
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the formation of a daughter centriole of an existing centriole." [GOC:ai]
is_a: GO:0010824 ! regulation of centrosome duplication
is_a: GO:1902115 ! regulation of organelle assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007099 ! centriole replication
relationship: regulates GO:0007099 ! centriole replication

[Term]
id: GO:0046600
name: negative regulation of centriole replication
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of centriole replication." [GOC:ai]
synonym: "down regulation of centriole replication" EXACT []
synonym: "down-regulation of centriole replication" EXACT []
synonym: "downregulation of centriole replication" EXACT []
synonym: "inhibition of centriole replication" NARROW []
is_a: GO:0010826 ! negative regulation of centrosome duplication
is_a: GO:0046599 ! regulation of centriole replication
is_a: GO:1902116 ! negative regulation of organelle assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007099 ! centriole replication
relationship: negatively_regulates GO:0007099 ! centriole replication

[Term]
id: GO:0046601
name: positive regulation of centriole replication
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of centriole replication." [GOC:ai]
synonym: "activation of centriole replication" NARROW []
synonym: "stimulation of centriole replication" NARROW []
synonym: "up regulation of centriole replication" EXACT []
synonym: "up-regulation of centriole replication" EXACT []
synonym: "upregulation of centriole replication" EXACT []
is_a: GO:0010825 ! positive regulation of centrosome duplication
is_a: GO:0046599 ! regulation of centriole replication
is_a: GO:1902117 ! positive regulation of organelle assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007099 ! centriole replication
relationship: positively_regulates GO:0007099 ! centriole replication

[Term]
id: GO:0046602
name: regulation of mitotic centrosome separation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the separation of duplicated centrosome components at the beginning of mitosis." [GOC:ai]
is_a: GO:0007088 ! regulation of mitotic nuclear division
is_a: GO:0046605 ! regulation of centrosome cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007100 ! mitotic centrosome separation
relationship: regulates GO:0007100 ! mitotic centrosome separation

[Term]
id: GO:0046603
name: negative regulation of mitotic centrosome separation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of centrosome separation." [GOC:ai]
synonym: "down regulation of mitotic centrosome separation" EXACT []
synonym: "down-regulation of mitotic centrosome separation" EXACT []
synonym: "downregulation of mitotic centrosome separation" EXACT []
synonym: "inhibition of mitotic centrosome separation" NARROW []
is_a: GO:0045839 ! negative regulation of mitotic nuclear division
is_a: GO:0046602 ! regulation of mitotic centrosome separation
is_a: GO:0046606 ! negative regulation of centrosome cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007100 ! mitotic centrosome separation
relationship: negatively_regulates GO:0007100 ! mitotic centrosome separation

[Term]
id: GO:0046604
name: positive regulation of mitotic centrosome separation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of centrosome separation." [GOC:ai]
synonym: "activation of mitotic centrosome separation" NARROW []
synonym: "stimulation of mitotic centrosome separation" NARROW []
synonym: "up regulation of mitotic centrosome separation" EXACT []
synonym: "up-regulation of mitotic centrosome separation" EXACT []
synonym: "upregulation of mitotic centrosome separation" EXACT []
is_a: GO:0045840 ! positive regulation of mitotic nuclear division
is_a: GO:0046602 ! regulation of mitotic centrosome separation
is_a: GO:0046607 ! positive regulation of centrosome cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007100 ! mitotic centrosome separation
relationship: positively_regulates GO:0007100 ! mitotic centrosome separation

[Term]
id: GO:0046605
name: regulation of centrosome cycle
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the centrosome cycle, the processes of centrosome duplication and separation." [GOC:ai]
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0070507 ! regulation of microtubule cytoskeleton organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007098 ! centrosome cycle
relationship: regulates GO:0007098 ! centrosome cycle

[Term]
id: GO:0046606
name: negative regulation of centrosome cycle
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the centrosome cycle." [GOC:ai]
synonym: "down regulation of centrosome cycle" EXACT []
synonym: "down-regulation of centrosome cycle" EXACT []
synonym: "downregulation of centrosome cycle" EXACT []
synonym: "inhibition of centrosome cycle" NARROW []
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0046605 ! regulation of centrosome cycle
is_a: GO:0051494 ! negative regulation of cytoskeleton organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007098 ! centrosome cycle
relationship: negatively_regulates GO:0007098 ! centrosome cycle

[Term]
id: GO:0046607
name: positive regulation of centrosome cycle
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the centrosome cycle." [GOC:ai]
synonym: "activation of centrosome cycle" NARROW []
synonym: "stimulation of centrosome cycle" NARROW []
synonym: "up regulation of centrosome cycle" EXACT []
synonym: "up-regulation of centrosome cycle" EXACT []
synonym: "upregulation of centrosome cycle" EXACT []
is_a: GO:0046605 ! regulation of centrosome cycle
is_a: GO:0051495 ! positive regulation of cytoskeleton organization
is_a: GO:0090068 ! positive regulation of cell cycle process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007098 ! centrosome cycle
relationship: positively_regulates GO:0007098 ! centrosome cycle

[Term]
id: GO:0046608
name: carotenoid isomerase activity
namespace: molecular_function
def: "Catalysis of the isomerization of poly-cis-carotenoids to all-trans-carotenoids." [PMID:11884677]
is_a: GO:0016859 ! cis-trans isomerase activity

[Term]
id: GO:0046609
name: voltage-gated sulfate antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + solute(in) = solute(in) + sulfate(out), by a channel in a cell membrane whose opening is governed by the membrane potential." [GOC:mah]
synonym: "prestin" NARROW []
synonym: "voltage gated sulfate antiporter activity" EXACT []
synonym: "voltage-dependent sulfate antiporter activity" EXACT []
synonym: "voltage-sensitive sulfate antiporter activity" EXACT []
synonym: "voltage-sensitive sulphate antiporter activity" EXACT []
is_a: GO:0015297 ! antiporter activity

[Term]
id: GO:0046610
name: lysosomal proton-transporting V-type ATPase, V0 domain
namespace: cellular_component
def: "The V0 domain of a proton-transporting V-type ATPase found in the lysosomal membrane." [GOC:mah]
synonym: "lysosomal hydrogen ion-transporting ATPase V0 domain" EXACT []
is_a: GO:0000220 ! vacuolar proton-transporting V-type ATPase, V0 domain
intersection_of: GO:0033179 ! proton-transporting V-type ATPase, V0 domain
intersection_of: part_of GO:0005764 ! lysosome
relationship: part_of GO:0005764 ! lysosome
relationship: part_of GO:0046611 ! lysosomal proton-transporting V-type ATPase complex

[Term]
id: GO:0046611
name: lysosomal proton-transporting V-type ATPase complex
namespace: cellular_component
def: "A proton-transporting two-sector ATPase complex found in the lysosomal membrane, where it acts as a proton pump to mediate acidification of the lysosomal lumen." [GOC:mah, ISBN:0716743663, PMID:16449553]
synonym: "lysosomal hydrogen-translocating V-type ATPase complex" EXACT []
synonym: "lysosomal membrane hydrogen-transporting ATPase" BROAD []
is_a: GO:0016471 ! vacuolar proton-transporting V-type ATPase complex
intersection_of: GO:0033176 ! proton-transporting V-type ATPase complex
intersection_of: part_of GO:0005764 ! lysosome
relationship: part_of GO:0005764 ! lysosome
relationship: part_of GO:0005765 ! lysosomal membrane

[Term]
id: GO:0046612
name: lysosomal proton-transporting V-type ATPase, V1 domain
namespace: cellular_component
def: "The V1 domain of a proton-transporting V-type ATPase found in the lysosomal membrane." [GOC:mah]
synonym: "lysosomal hydrogen ion-transporting ATPase V1 domain" EXACT []
is_a: GO:0000221 ! vacuolar proton-transporting V-type ATPase, V1 domain
intersection_of: GO:0033180 ! proton-transporting V-type ATPase, V1 domain
intersection_of: part_of GO:0005764 ! lysosome
relationship: part_of GO:0005764 ! lysosome
relationship: part_of GO:0046611 ! lysosomal proton-transporting V-type ATPase complex

[Term]
id: GO:0046615
name: obsolete re-entry into mitotic cell cycle after pheromone arrest (sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. The resumption of the Saccharomyces mitotic cell division cycle by pheromone-arrested cells that have not mated." [GOC:krc, PMID:9927449]
comment: This term was made obsolete because there is no evidence that this process is unique to Saccharomyces.
synonym: "re-entry into mitotic cell cycle after pheromone arrest (sensu Saccharomyces)" EXACT []
is_obsolete: true
replaced_by: GO:0000321

[Term]
id: GO:0046617
name: obsolete nucleolar size increase (sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. The process of nucleolar expansion, as seen in Saccharomyces." [GOC:ai]
comment: This term was made obsolete because it does not describe a biological process.
synonym: "nucleolar size increase (sensu Saccharomyces)" EXACT []
is_obsolete: true
consider: GO:0007571
consider: GO:0007576

[Term]
id: GO:0046618
name: drug export
namespace: biological_process
def: "The directed movement of a drug, a substance used in the diagnosis, treatment or prevention of a disease, out of a cell or organelle." [GOC:go_curators]
is_a: GO:0015893 ! drug transport

[Term]
id: GO:0046619
name: optic placode formation involved in camera-type eye formation
namespace: biological_process
def: "Establishment and formation of the optic placode, paired ectodermal placodes that become invaginated to form the embryonic lens vesicles." [GOC:dph, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb]
synonym: "optic placode formation in camera-type eye" EXACT []
synonym: "optic placode formation involved in camera-style eye" EXACT []
is_a: GO:0001743 ! optic placode formation
relationship: part_of GO:0060900 ! embryonic camera-type eye formation

[Term]
id: GO:0046620
name: regulation of organ growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb]
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035265 ! organ growth
relationship: regulates GO:0035265 ! organ growth

[Term]
id: GO:0046621
name: negative regulation of organ growth
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb]
is_a: GO:0046620 ! regulation of organ growth
is_a: GO:0048640 ! negative regulation of developmental growth
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035265 ! organ growth
relationship: negatively_regulates GO:0035265 ! organ growth

[Term]
id: GO:0046622
name: positive regulation of organ growth
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb]
is_a: GO:0046620 ! regulation of organ growth
is_a: GO:0048639 ! positive regulation of developmental growth
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035265 ! organ growth
relationship: positively_regulates GO:0035265 ! organ growth

[Term]
id: GO:0046623
name: sphingolipid-translocating ATPase activity
namespace: molecular_function
def: "Catalysis of the movement of sphingolipids from one membrane face to the other ('flippase' activity), driven by the hydrolysis of ATP." [GOC:ai, PMID:12034738]
synonym: "sphingolipid flippase activity" EXACT []
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances
is_a: GO:0046624 ! sphingolipid transporter activity

[Term]
id: GO:0046624
name: sphingolipid transporter activity
namespace: molecular_function
def: "Enables the directed movement of sphingolipids into, out of or within a cell, or between cells. Sphingolipids are a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:ai, ISBN:0198506732]
is_a: GO:0005319 ! lipid transporter activity

[Term]
id: GO:0046625
name: sphingolipid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with sphingolipids, a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [ISBN:0198506732]
is_a: GO:0008289 ! lipid binding

[Term]
id: GO:0046626
name: regulation of insulin receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of insulin receptor signaling." [GOC:bf]
synonym: "regulation of insulin receptor signalling pathway" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:1900076 ! regulation of cellular response to insulin stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008286 ! insulin receptor signaling pathway
relationship: regulates GO:0008286 ! insulin receptor signaling pathway

[Term]
id: GO:0046627
name: negative regulation of insulin receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling." [GOC:bf]
synonym: "down regulation of insulin receptor signaling pathway" EXACT []
synonym: "down-regulation of insulin receptor signaling pathway" EXACT []
synonym: "downregulation of insulin receptor signaling pathway" EXACT []
synonym: "inhibition of insulin receptor signaling pathway" NARROW []
synonym: "negative regulation of insulin receptor signalling pathway" EXACT []
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0046626 ! regulation of insulin receptor signaling pathway
is_a: GO:1900077 ! negative regulation of cellular response to insulin stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008286 ! insulin receptor signaling pathway
relationship: negatively_regulates GO:0008286 ! insulin receptor signaling pathway

[Term]
id: GO:0046628
name: positive regulation of insulin receptor signaling pathway
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of insulin receptor signaling." [GOC:bf]
synonym: "activation of insulin receptor signaling pathway" NARROW []
synonym: "positive regulation of insulin receptor signalling pathway" EXACT []
synonym: "stimulation of insulin receptor signaling pathway" NARROW []
synonym: "up regulation of insulin receptor signaling pathway" EXACT []
synonym: "up-regulation of insulin receptor signaling pathway" EXACT []
synonym: "upregulation of insulin receptor signaling pathway" EXACT []
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0046626 ! regulation of insulin receptor signaling pathway
is_a: GO:1900078 ! positive regulation of cellular response to insulin stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008286 ! insulin receptor signaling pathway
relationship: positively_regulates GO:0008286 ! insulin receptor signaling pathway

[Term]
id: GO:0046629
name: gamma-delta T cell activation
namespace: biological_process
def: "The change in morphology and behavior of a gamma-delta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:add]
synonym: "gamma-delta T lymphocyte activation" EXACT []
synonym: "gamma-delta T-cell activation" EXACT []
synonym: "gamma-delta T-lymphocyte activation" EXACT []
is_a: GO:0042110 ! T cell activation

[Term]
id: GO:0046630
name: gamma-delta T cell proliferation
namespace: biological_process
def: "The expansion of a gamma-delta T cell population by cell division." [GOC:ai]
synonym: "gamma-delta T lymphocyte proliferation" EXACT []
synonym: "gamma-delta T-cell proliferation" EXACT []
synonym: "gamma-delta T-lymphocyte proliferation" EXACT []
is_a: GO:0042098 ! T cell proliferation
is_a: GO:0046629 ! gamma-delta T cell activation

[Term]
id: GO:0046631
name: alpha-beta T cell activation
namespace: biological_process
def: "The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:add]
synonym: "alpha-beta T lymphocyte activation" EXACT []
synonym: "alpha-beta T-cell activation" EXACT []
synonym: "alpha-beta T-lymphocyte activation" EXACT []
is_a: GO:0042110 ! T cell activation

[Term]
id: GO:0046632
name: alpha-beta T cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of an alpha-beta T cell. An alpha-beta T cell is a T cell that expresses an alpha-beta T cell receptor complex." [CL:0000789, GOC:ai]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "alpha-beta T cell development" RELATED [GOC:add]
synonym: "alpha-beta T lymphocyte differentiation" EXACT []
synonym: "alpha-beta T-cell differentiation" EXACT []
synonym: "alpha-beta T-lymphocyte differentiation" EXACT []
is_a: GO:0030217 ! T cell differentiation
is_a: GO:0046631 ! alpha-beta T cell activation

[Term]
id: GO:0046633
name: alpha-beta T cell proliferation
namespace: biological_process
def: "The expansion of an alpha-beta T cell population by cell division." [GOC:ai]
synonym: "alpha-beta T lymphocyte proliferation" EXACT []
synonym: "alpha-beta T-cell proliferation" EXACT []
synonym: "alpha-beta T-lymphocyte proliferation" EXACT []
is_a: GO:0042098 ! T cell proliferation
is_a: GO:0046631 ! alpha-beta T cell activation

[Term]
id: GO:0046634
name: regulation of alpha-beta T cell activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of alpha-beta T cell activation." [GOC:ai]
synonym: "regulation of alpha-beta T lymphocyte activation" EXACT []
synonym: "regulation of alpha-beta T-cell activation" EXACT []
synonym: "regulation of alpha-beta T-lymphocyte activation" EXACT []
is_a: GO:0050863 ! regulation of T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0046631 ! alpha-beta T cell activation
relationship: regulates GO:0046631 ! alpha-beta T cell activation

[Term]
id: GO:0046635
name: positive regulation of alpha-beta T cell activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of alpha-beta T cell activation." [GOC:ai]
synonym: "activation of alpha-beta T cell activation" NARROW []
synonym: "positive regulation of alpha-beta T lymphocyte activation" EXACT []
synonym: "positive regulation of alpha-beta T-cell activation" EXACT []
synonym: "positive regulation of alpha-beta T-lymphocyte activation" EXACT []
synonym: "stimulation of alpha-beta T cell activation" NARROW []
synonym: "up regulation of alpha-beta T cell activation" EXACT []
synonym: "up-regulation of alpha-beta T cell activation" EXACT []
synonym: "upregulation of alpha-beta T cell activation" EXACT []
is_a: GO:0046634 ! regulation of alpha-beta T cell activation
is_a: GO:0050870 ! positive regulation of T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0046631 ! alpha-beta T cell activation
relationship: positively_regulates GO:0046631 ! alpha-beta T cell activation

[Term]
id: GO:0046636
name: negative regulation of alpha-beta T cell activation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell activation." [GOC:ai]
synonym: "down regulation of alpha-beta T cell activation" EXACT []
synonym: "down-regulation of alpha-beta T cell activation" EXACT []
synonym: "downregulation of alpha-beta T cell activation" EXACT []
synonym: "inhibition of alpha-beta T cell activation" NARROW []
synonym: "negative regulation of alpha-beta T lymphocyte activation" EXACT []
synonym: "negative regulation of alpha-beta T-cell activation" EXACT []
synonym: "negative regulation of alpha-beta T-lymphocyte activation" EXACT []
is_a: GO:0046634 ! regulation of alpha-beta T cell activation
is_a: GO:0050868 ! negative regulation of T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0046631 ! alpha-beta T cell activation
relationship: negatively_regulates GO:0046631 ! alpha-beta T cell activation

[Term]
id: GO:0046637
name: regulation of alpha-beta T cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of alpha-beta T cell differentiation." [GOC:ai]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "regulation of alpha-beta T cell development" RELATED [GOC:add]
synonym: "regulation of alpha-beta T lymphocyte differentiation" EXACT []
synonym: "regulation of alpha-beta T-cell differentiation" EXACT []
synonym: "regulation of alpha-beta T-lymphocyte differentiation" EXACT []
is_a: GO:0045580 ! regulation of T cell differentiation
is_a: GO:0046634 ! regulation of alpha-beta T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0046632 ! alpha-beta T cell differentiation
relationship: regulates GO:0046632 ! alpha-beta T cell differentiation

[Term]
id: GO:0046638
name: positive regulation of alpha-beta T cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of alpha-beta T cell differentiation." [GOC:ai]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "activation of alpha-beta T cell differentiation" NARROW []
synonym: "positive regulation of alpha-beta T cell development" RELATED [GOC:add]
synonym: "positive regulation of alpha-beta T lymphocyte differentiation" EXACT []
synonym: "positive regulation of alpha-beta T-cell differentiation" EXACT []
synonym: "positive regulation of alpha-beta T-lymphocyte differentiation" EXACT []
synonym: "stimulation of alpha-beta T cell differentiation" NARROW []
synonym: "up regulation of alpha-beta T cell differentiation" EXACT []
synonym: "up-regulation of alpha-beta T cell differentiation" EXACT []
synonym: "upregulation of alpha-beta T cell differentiation" EXACT []
is_a: GO:0045582 ! positive regulation of T cell differentiation
is_a: GO:0046635 ! positive regulation of alpha-beta T cell activation
is_a: GO:0046637 ! regulation of alpha-beta T cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0046632 ! alpha-beta T cell differentiation
relationship: positively_regulates GO:0046632 ! alpha-beta T cell differentiation

[Term]
id: GO:0046639
name: negative regulation of alpha-beta T cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell differentiation." [GOC:ai]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "down regulation of alpha-beta T cell differentiation" EXACT []
synonym: "down-regulation of alpha-beta T cell differentiation" EXACT []
synonym: "downregulation of alpha-beta T cell differentiation" EXACT []
synonym: "inhibition of alpha-beta T cell differentiation" NARROW []
synonym: "negative regulation of alpha-beta T cell development" RELATED [GOC:add]
synonym: "negative regulation of alpha-beta T lymphocyte differentiation" EXACT []
synonym: "negative regulation of alpha-beta T-cell differentiation" EXACT []
synonym: "negative regulation of alpha-beta T-lymphocyte differentiation" EXACT []
is_a: GO:0045581 ! negative regulation of T cell differentiation
is_a: GO:0046636 ! negative regulation of alpha-beta T cell activation
is_a: GO:0046637 ! regulation of alpha-beta T cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0046632 ! alpha-beta T cell differentiation
relationship: negatively_regulates GO:0046632 ! alpha-beta T cell differentiation

[Term]
id: GO:0046640
name: regulation of alpha-beta T cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of alpha-beta T cell proliferation." [GOC:ai]
synonym: "regulation of alpha-beta T lymphocyte proliferation" EXACT []
synonym: "regulation of alpha-beta T-cell proliferation" EXACT []
synonym: "regulation of alpha-beta T-lymphocyte proliferation" EXACT []
is_a: GO:0042129 ! regulation of T cell proliferation
is_a: GO:0046634 ! regulation of alpha-beta T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0046633 ! alpha-beta T cell proliferation
relationship: regulates GO:0046633 ! alpha-beta T cell proliferation

[Term]
id: GO:0046641
name: positive regulation of alpha-beta T cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of alpha-beta T cell proliferation." [GOC:ai]
synonym: "activation of alpha-beta T cell proliferation" NARROW []
synonym: "positive regulation of alpha-beta T lymphocyte proliferation" EXACT []
synonym: "positive regulation of alpha-beta T-cell proliferation" EXACT []
synonym: "positive regulation of alpha-beta T-lymphocyte proliferation" EXACT []
synonym: "stimulation of alpha-beta T cell proliferation" NARROW []
synonym: "up regulation of alpha-beta T cell proliferation" EXACT []
synonym: "up-regulation of alpha-beta T cell proliferation" EXACT []
synonym: "upregulation of alpha-beta T cell proliferation" EXACT []
is_a: GO:0042102 ! positive regulation of T cell proliferation
is_a: GO:0046635 ! positive regulation of alpha-beta T cell activation
is_a: GO:0046640 ! regulation of alpha-beta T cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0046633 ! alpha-beta T cell proliferation
relationship: positively_regulates GO:0046633 ! alpha-beta T cell proliferation

[Term]
id: GO:0046642
name: negative regulation of alpha-beta T cell proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell proliferation." [GOC:ai]
synonym: "down regulation of alpha-beta T cell proliferation" EXACT []
synonym: "down-regulation of alpha-beta T cell proliferation" EXACT []
synonym: "downregulation of alpha-beta T cell proliferation" EXACT []
synonym: "inhibition of alpha-beta T cell proliferation" NARROW []
synonym: "negative regulation of alpha-beta T lymphocyte proliferation" EXACT []
synonym: "negative regulation of alpha-beta T-cell proliferation" EXACT []
synonym: "negative regulation of alpha-beta T-lymphocyte proliferation" EXACT []
is_a: GO:0042130 ! negative regulation of T cell proliferation
is_a: GO:0046636 ! negative regulation of alpha-beta T cell activation
is_a: GO:0046640 ! regulation of alpha-beta T cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0046633 ! alpha-beta T cell proliferation
relationship: negatively_regulates GO:0046633 ! alpha-beta T cell proliferation

[Term]
id: GO:0046643
name: regulation of gamma-delta T cell activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gamma-delta T cell activation." [GOC:ai]
synonym: "regulation of gamma-delta T lymphocyte activation" EXACT []
synonym: "regulation of gamma-delta T-cell activation" EXACT []
synonym: "regulation of gamma-delta T-lymphocyte activation" EXACT []
is_a: GO:0050863 ! regulation of T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0046629 ! gamma-delta T cell activation
relationship: regulates GO:0046629 ! gamma-delta T cell activation

[Term]
id: GO:0046644
name: negative regulation of gamma-delta T cell activation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of gamma-delta T cell activation." [GOC:ai]
synonym: "down regulation of gamma-delta T cell activation" EXACT []
synonym: "down-regulation of gamma-delta T cell activation" EXACT []
synonym: "downregulation of gamma-delta T cell activation" EXACT []
synonym: "inhibition of gamma-delta T cell activation" NARROW []
synonym: "negative regulation of gamma-delta T lymphocyte activation" EXACT []
synonym: "negative regulation of gamma-delta T-cell activation" EXACT []
synonym: "negative regulation of gamma-delta T-lymphocyte activation" EXACT []
is_a: GO:0046643 ! regulation of gamma-delta T cell activation
is_a: GO:0050868 ! negative regulation of T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0046629 ! gamma-delta T cell activation
relationship: negatively_regulates GO:0046629 ! gamma-delta T cell activation

[Term]
id: GO:0046645
name: positive regulation of gamma-delta T cell activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of gamma-delta T cell activation." [GOC:ai]
synonym: "activation of gamma-delta T cell activation" NARROW []
synonym: "positive regulation of gamma-delta T lymphocyte activation" EXACT []
synonym: "positive regulation of gamma-delta T-cell activation" EXACT []
synonym: "positive regulation of gamma-delta T-lymphocyte activation" EXACT []
synonym: "stimulation of gamma-delta T cell activation" NARROW []
synonym: "up regulation of gamma-delta T cell activation" EXACT []
synonym: "up-regulation of gamma-delta T cell activation" EXACT []
synonym: "upregulation of gamma-delta T cell activation" EXACT []
is_a: GO:0046643 ! regulation of gamma-delta T cell activation
is_a: GO:0050870 ! positive regulation of T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0046629 ! gamma-delta T cell activation
relationship: positively_regulates GO:0046629 ! gamma-delta T cell activation

[Term]
id: GO:0046646
name: regulation of gamma-delta T cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gamma-delta T cell proliferation." [GOC:ai]
synonym: "regulation of gamma-delta T lymphocyte proliferation" EXACT []
synonym: "regulation of gamma-delta T-cell proliferation" EXACT []
synonym: "regulation of gamma-delta T-lymphocyte proliferation" EXACT []
is_a: GO:0042129 ! regulation of T cell proliferation
is_a: GO:0046643 ! regulation of gamma-delta T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0046630 ! gamma-delta T cell proliferation
relationship: regulates GO:0046630 ! gamma-delta T cell proliferation

[Term]
id: GO:0046647
name: negative regulation of gamma-delta T cell proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of gamma-delta T cell proliferation." [GOC:ai]
synonym: "down regulation of gamma-delta T cell proliferation" EXACT []
synonym: "down-regulation of gamma-delta T cell proliferation" EXACT []
synonym: "downregulation of gamma-delta T cell proliferation" EXACT []
synonym: "inhibition of gamma-delta T cell proliferation" NARROW []
synonym: "negative regulation of gamma-delta T lymphocyte proliferation" EXACT []
synonym: "negative regulation of gamma-delta T-cell proliferation" EXACT []
synonym: "negative regulation of gamma-delta T-lymphocyte proliferation" EXACT []
is_a: GO:0042130 ! negative regulation of T cell proliferation
is_a: GO:0046644 ! negative regulation of gamma-delta T cell activation
is_a: GO:0046646 ! regulation of gamma-delta T cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0046630 ! gamma-delta T cell proliferation
relationship: negatively_regulates GO:0046630 ! gamma-delta T cell proliferation

[Term]
id: GO:0046648
name: positive regulation of gamma-delta T cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of gamma-delta T cell proliferation." [GOC:ai]
synonym: "activation of gamma-delta T cell proliferation" NARROW []
synonym: "positive regulation of gamma-delta T lymphocyte proliferation" EXACT []
synonym: "positive regulation of gamma-delta T-cell proliferation" EXACT []
synonym: "positive regulation of gamma-delta T-lymphocyte proliferation" EXACT []
synonym: "stimulation of gamma-delta T cell proliferation" NARROW []
synonym: "up regulation of gamma-delta T cell proliferation" EXACT []
synonym: "up-regulation of gamma-delta T cell proliferation" EXACT []
synonym: "upregulation of gamma-delta T cell proliferation" EXACT []
is_a: GO:0042102 ! positive regulation of T cell proliferation
is_a: GO:0046645 ! positive regulation of gamma-delta T cell activation
is_a: GO:0046646 ! regulation of gamma-delta T cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0046630 ! gamma-delta T cell proliferation
relationship: positively_regulates GO:0046630 ! gamma-delta T cell proliferation

[Term]
id: GO:0046649
name: lymphocyte activation
namespace: biological_process
def: "A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735140]
is_a: GO:0045321 ! leukocyte activation

[Term]
id: GO:0046651
name: lymphocyte proliferation
namespace: biological_process
def: "The expansion of a lymphocyte population by cell division." [GOC:ai]
is_a: GO:0032943 ! mononuclear cell proliferation
is_a: GO:0046649 ! lymphocyte activation

[Term]
id: GO:0046653
name: tetrahydrofolate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group." [ISBN:0198506732]
subset: gosubset_prok
synonym: "tetrahydrofolate metabolism" EXACT []
is_a: GO:0006760 ! folic acid-containing compound metabolic process

[Term]
id: GO:0046654
name: tetrahydrofolate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group." [ISBN:0198506732]
subset: gosubset_prok
synonym: "tetrahydrofolate anabolism" EXACT []
synonym: "tetrahydrofolate biosynthesis" EXACT []
synonym: "tetrahydrofolate formation" EXACT []
synonym: "tetrahydrofolate synthesis" EXACT []
xref: MetaCyc:FOLSYN-PWY
is_a: GO:0009396 ! folic acid-containing compound biosynthetic process
is_a: GO:0046653 ! tetrahydrofolate metabolic process

[Term]
id: GO:0046655
name: folic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines." [ISBN:0198506732]
subset: gosubset_prok
synonym: "folate metabolic process" EXACT []
synonym: "folate metabolism" EXACT []
synonym: "folic acid metabolism" EXACT []
synonym: "vitamin B9 metabolic process" EXACT []
synonym: "vitamin B9 metabolism" EXACT []
synonym: "vitamin M metabolic process" EXACT []
synonym: "vitamin M metabolism" EXACT []
xref: Reactome:REACT_100874 "Metabolism of folate and pterines, Gallus gallus"
xref: Reactome:REACT_101254 "Metabolism of folate and pterines, Bos taurus"
xref: Reactome:REACT_101455 "Metabolism of folate and pterines, Xenopus tropicalis"
xref: Reactome:REACT_102698 "Metabolism of folate and pterines, Staphylococcus aureus N315"
xref: Reactome:REACT_102968 "Metabolism of folate and pterines, Taeniopygia guttata"
xref: Reactome:REACT_102980 "Metabolism of folate and pterines, Sus scrofa"
xref: Reactome:REACT_107303 "Metabolism of folate and pterines, Schizosaccharomyces pombe"
xref: Reactome:REACT_108321 "Metabolism of folate and pterines, Oryza sativa"
xref: Reactome:REACT_108536 "Metabolism of folate and pterines, Danio rerio"
xref: Reactome:REACT_11167 "Metabolism of folate and pterines, Homo sapiens"
xref: Reactome:REACT_29358 "Metabolism of folate and pterines, Arabidopsis thaliana"
xref: Reactome:REACT_30259 "Metabolism of folate and pterines, Canis familiaris"
xref: Reactome:REACT_30881 "Metabolism of folate and pterines, Caenorhabditis elegans"
xref: Reactome:REACT_31379 "Metabolism of folate and pterines, Escherichia coli"
xref: Reactome:REACT_34693 "Metabolism of folate and pterines, Plasmodium falciparum"
xref: Reactome:REACT_36785 "Metabolism of folate and pterines, Dictyostelium discoideum"
xref: Reactome:REACT_62805 "Metabolism of folate and pterines, Rattus norvegicus"
xref: Reactome:REACT_86332 "Metabolism of folate and pterines, Mycobacterium tuberculosis"
xref: Reactome:REACT_93230 "Metabolism of folate and pterines, Drosophila melanogaster"
xref: Reactome:REACT_94762 "Metabolism of folate and pterines, Mus musculus"
xref: Reactome:REACT_94877 "Metabolism of folate and pterines, Saccharomyces cerevisiae"
is_a: GO:0006760 ! folic acid-containing compound metabolic process
is_a: GO:0006767 ! water-soluble vitamin metabolic process
is_a: GO:0043648 ! dicarboxylic acid metabolic process

[Term]
id: GO:0046656
name: folic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of folic acid, pteroylglutamic acid." [GOC:ai]
subset: gosubset_prok
synonym: "folate biosynthesis" EXACT []
synonym: "folate biosynthetic process" EXACT []
synonym: "folic acid anabolism" EXACT []
synonym: "folic acid biosynthesis" EXACT []
synonym: "folic acid formation" EXACT []
synonym: "folic acid synthesis" EXACT []
synonym: "vitamin B9 biosynthesis" EXACT []
synonym: "vitamin B9 biosynthetic process" EXACT []
synonym: "vitamin M biosynthesis" EXACT []
synonym: "vitamin M biosynthetic process" EXACT []
xref: MetaCyc:FOLSYN-PWY
xref: Wikipedia:Folic_acid
is_a: GO:0009396 ! folic acid-containing compound biosynthetic process
is_a: GO:0042364 ! water-soluble vitamin biosynthetic process
is_a: GO:0043650 ! dicarboxylic acid biosynthetic process
is_a: GO:0046655 ! folic acid metabolic process

[Term]
id: GO:0046657
name: folic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of folic acid, pteroylglutamic acid." [GOC:ai]
subset: gosubset_prok
synonym: "folate catabolic process" EXACT []
synonym: "folate catabolism" EXACT []
synonym: "folic acid breakdown" EXACT []
synonym: "folic acid catabolism" EXACT []
synonym: "folic acid degradation" EXACT []
synonym: "vitamin B9 catabolic process" EXACT []
synonym: "vitamin B9 catabolism" EXACT []
synonym: "vitamin M catabolic process" EXACT []
synonym: "vitamin M catabolism" EXACT []
is_a: GO:0009397 ! folic acid-containing compound catabolic process
is_a: GO:0042365 ! water-soluble vitamin catabolic process
is_a: GO:0043649 ! dicarboxylic acid catabolic process
is_a: GO:0046655 ! folic acid metabolic process

[Term]
id: GO:0046658
name: anchored component of plasma membrane
namespace: cellular_component
def: "The component of the plasma membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group, that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:mah]
synonym: "anchored to plasma membrane" NARROW []
synonym: "plasma membrane, GPI-anchored" NARROW []
is_a: GO:0031225 ! anchored component of membrane
is_a: GO:0031226 ! intrinsic component of plasma membrane
intersection_of: GO:0031225 ! anchored component of membrane
intersection_of: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0005886 ! plasma membrane

[Term]
id: GO:0046659
name: digestive hormone activity
namespace: molecular_function
def: "The action characteristic of a hormone that takes part in the digestion process." [GOC:ai]
synonym: "secretin" NARROW []
is_a: GO:0005179 ! hormone activity

[Term]
id: GO:0046660
name: female sex differentiation
namespace: biological_process
def: "The establishment of the sex of a female organism by physical differentiation." [GOC:bf]
is_a: GO:0007548 ! sex differentiation
relationship: part_of GO:0007275 ! multicellular organism development

[Term]
id: GO:0046661
name: male sex differentiation
namespace: biological_process
def: "The establishment of the sex of a male organism by physical differentiation." [GOC:bf]
is_a: GO:0007548 ! sex differentiation
relationship: part_of GO:0007275 ! multicellular organism development

[Term]
id: GO:0046662
name: regulation of oviposition
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the deposition of eggs, either fertilized or not, upon a surface or into a medium." [GOC:ai]
is_a: GO:0043900 ! regulation of multi-organism process
is_a: GO:0050795 ! regulation of behavior
is_a: GO:0051239 ! regulation of multicellular organismal process
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0018991 ! oviposition
relationship: regulates GO:0018991 ! oviposition

[Term]
id: GO:0046663
name: dorsal closure, leading edge cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a leading edge cell, the dorsal-most cells of the epidermis that migrates during dorsal closure." [GOC:ai, PMID:12147138]
is_a: GO:0035026 ! leading edge cell differentiation
intersection_of: GO:0035026 ! leading edge cell differentiation
intersection_of: part_of GO:0007391 ! dorsal closure
relationship: part_of GO:0007391 ! dorsal closure
relationship: part_of GO:0007392 ! initiation of dorsal closure

[Term]
id: GO:0046664
name: dorsal closure, amnioserosa morphology change
namespace: biological_process
def: "The changes that occur during dorsal closure of the shape and structure of the amnioserosa, an epithelium that occupies the dorsal side of the embryo." [PMID:12147138]
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0048729 ! tissue morphogenesis
relationship: part_of GO:0007391 ! dorsal closure

[Term]
id: GO:0046665
name: amnioserosa maintenance
namespace: biological_process
def: "Maintenance of the amnioserosa, an epithelium that occupies a hole in the embryonic dorsal epidermis." [GOC:bf]
is_a: GO:0001894 ! tissue homeostasis
relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm

[Term]
id: GO:0046666
name: retinal cell programmed cell death
namespace: biological_process
def: "Programmed cell death that occurs in the developing retina." [GOC:bf]
synonym: "programmed cell death, retina cells" EXACT []
synonym: "programmed cell death, retinal cells" EXACT []
synonym: "retina cell programmed cell death" EXACT []
synonym: "retina programmed cell death" EXACT []
synonym: "retinal programmed cell death" EXACT []
is_a: GO:0010623 ! developmental programmed cell death
relationship: part_of GO:0048592 ! eye morphogenesis

[Term]
id: GO:0046667
name: compound eye retinal cell programmed cell death
namespace: biological_process
def: "Programmed cell death that occurs in the retina to remove excess cells between ommatidia, thus resulting in a hexagonal lattice, precise with respect to cell number and position surrounding each ommatidium." [PMID:12006672]
is_a: GO:0046666 ! retinal cell programmed cell death
relationship: part_of GO:0001745 ! compound eye morphogenesis

[Term]
id: GO:0046668
name: regulation of retinal cell programmed cell death
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the retina." [GOC:ai, GOC:tb]
synonym: "regulation of retinal programmed cell death" EXACT [GOC:tb]
is_a: GO:0043067 ! regulation of programmed cell death
is_a: GO:0060284 ! regulation of cell development
is_a: GO:2000027 ! regulation of organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0046666 ! retinal cell programmed cell death
relationship: regulates GO:0046666 ! retinal cell programmed cell death

[Term]
id: GO:0046669
name: regulation of compound eye retinal cell programmed cell death
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai]
synonym: "regulation of retinal cell programmed cell death" BROAD []
is_a: GO:0046668 ! regulation of retinal cell programmed cell death
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0046667 ! compound eye retinal cell programmed cell death
relationship: regulates GO:0046667 ! compound eye retinal cell programmed cell death

[Term]
id: GO:0046670
name: positive regulation of retinal cell programmed cell death
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the retina." [GOC:ai, GOC:tb]
synonym: "activation of retinal programmed cell death" NARROW []
synonym: "positive regulation of retinal programmed cell death" EXACT [GOC:tb]
synonym: "stimulation of retinal programmed cell death" NARROW []
synonym: "up regulation of retinal programmed cell death" EXACT []
synonym: "up-regulation of retinal programmed cell death" EXACT []
synonym: "upregulation of retinal programmed cell death" EXACT []
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0043068 ! positive regulation of programmed cell death
is_a: GO:0046668 ! regulation of retinal cell programmed cell death
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0046666 ! retinal cell programmed cell death
relationship: positively_regulates GO:0046666 ! retinal cell programmed cell death

[Term]
id: GO:0046671
name: negative regulation of retinal cell programmed cell death
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the retina." [GOC:ai, GOC:tb]
synonym: "down regulation of retinal programmed cell death" EXACT []
synonym: "down-regulation of retinal programmed cell death" EXACT []
synonym: "downregulation of retinal programmed cell death" EXACT []
synonym: "inhibition of retinal programmed cell death" NARROW []
synonym: "negative regulation of retinal programmed cell death" EXACT [GOC:tb]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0043069 ! negative regulation of programmed cell death
is_a: GO:0046668 ! regulation of retinal cell programmed cell death
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0046666 ! retinal cell programmed cell death
relationship: negatively_regulates GO:0046666 ! retinal cell programmed cell death

[Term]
id: GO:0046672
name: positive regulation of compound eye retinal cell programmed cell death
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai]
synonym: "activation of retinal cell programmed cell death" BROAD []
synonym: "positive regulation of retinal cell programmed cell death" BROAD []
synonym: "stimulation of retinal cell programmed cell death" BROAD []
synonym: "up regulation of retinal cell programmed cell death" BROAD []
synonym: "up-regulation of retinal cell programmed cell death" BROAD []
synonym: "upregulation of retinal cell programmed cell death" BROAD []
is_a: GO:0046669 ! regulation of compound eye retinal cell programmed cell death
is_a: GO:0046670 ! positive regulation of retinal cell programmed cell death
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0046667 ! compound eye retinal cell programmed cell death
relationship: positively_regulates GO:0046667 ! compound eye retinal cell programmed cell death

[Term]
id: GO:0046673
name: negative regulation of compound eye retinal cell programmed cell death
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai]
synonym: "down regulation of retinal cell programmed cell death" BROAD []
synonym: "down-regulation of retinal cell programmed cell death" BROAD []
synonym: "downregulation of retinal cell programmed cell death" BROAD []
synonym: "inhibition of retinal cell programmed cell death" BROAD []
synonym: "negative regulation of retina cell programmed cell death" BROAD []
synonym: "negative regulation of retinal cell programmed cell death" BROAD []
is_a: GO:0046669 ! regulation of compound eye retinal cell programmed cell death
is_a: GO:0046671 ! negative regulation of retinal cell programmed cell death
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0046667 ! compound eye retinal cell programmed cell death
relationship: negatively_regulates GO:0046667 ! compound eye retinal cell programmed cell death

[Term]
id: GO:0046676
name: negative regulation of insulin secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin." [GOC:ai]
synonym: "down regulation of insulin secretion" EXACT []
synonym: "down-regulation of insulin secretion" EXACT []
synonym: "downregulation of insulin secretion" EXACT []
synonym: "inhibition of insulin secretion" NARROW []
is_a: GO:0050709 ! negative regulation of protein secretion
is_a: GO:0050796 ! regulation of insulin secretion
is_a: GO:0090278 ! negative regulation of peptide hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030073 ! insulin secretion
relationship: negatively_regulates GO:0030073 ! insulin secretion

[Term]
id: GO:0046677
name: response to antibiotic
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms." [GOC:ai, GOC:ef]
subset: goslim_chembl
subset: gosubset_prok
synonym: "antibiotic susceptibility/resistance" RELATED []
is_a: GO:0009636 ! response to toxic substance

[Term]
id: GO:0046678
name: response to bacteriocin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacteriocin stimulus. A bacteriocin is a protein substance released by certain bacteria that kills but does not lyse closely related strains of bacteria. Specific bacteriocins attach to specific receptors on cell walls and induce specific metabolic block, e.g. cessation of nucleic acid or protein synthesis of oxidative phosphorylation." [ISBN:0721662544]
subset: gosubset_prok
synonym: "bacteriocin susceptibility/resistance" RELATED []
is_a: GO:0046677 ! response to antibiotic
is_a: GO:1901652 ! response to peptide

[Term]
id: GO:0046679
name: response to streptomycin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a streptomycin stimulus. Streptomycin is a commonly used antibiotic in cell culture media which acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome." [CHEBI:17076, GOC:curators]
synonym: "streptomycin susceptibility/resistance" RELATED []
is_a: GO:0046677 ! response to antibiotic
is_a: GO:1903416 ! response to glycoside

[Term]
id: GO:0046680
name: response to DDT
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a DDT stimulus. DDT, dichlorodiphenyltrichloroethane, is a chlorinated hydrocarbon pesticide moderately toxic to humans and other animals." [ISBN:0721662544]
subset: gosubset_prok
synonym: "DDT resistance" RELATED []
synonym: "DDT susceptibility/resistance" RELATED []
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0017085 ! response to insecticide

[Term]
id: GO:0046681
name: response to carbamate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbamate stimulus. Carbamates are a group of insecticides and parasiticides that act by inhibiting cholinesterase." [ISBN:0721662544]
synonym: "carbamate resistance" RELATED []
synonym: "carbamate susceptibility/resistance" RELATED []
is_a: GO:0017085 ! response to insecticide
is_a: GO:0043200 ! response to amino acid

[Term]
id: GO:0046682
name: response to cyclodiene
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclodiene stimulus. A cyclodiene is any organic insecticide (as dieldrin or chlordane) with a chlorinated methylene group forming a bridge across a 6-membered carbon ring." [ISBN:0877797099]
synonym: "cyclodiene resistance" RELATED []
synonym: "cyclodiene susceptibility/resistance" RELATED []
is_a: GO:0010033 ! response to organic substance
is_a: GO:0017085 ! response to insecticide

[Term]
id: GO:0046683
name: response to organophosphorus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organophosphorus stimulus. Organophosphorus is a compound containing phosphorus bound to an organic molecule; several organophosphorus compounds are used as insecticides, and they are highly toxic cholinesterase inhibitors." [ISBN:0721662544]
synonym: "organophosphorus resistance" RELATED []
synonym: "organophosphorus susceptibility/resistance" RELATED []
is_a: GO:0010033 ! response to organic substance

[Term]
id: GO:0046684
name: response to pyrethroid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pyrethroid stimulus. Pyrethroids are a group of growth regulators, analogous to insect juvenile hormones, that interfere with the development of insect larvae and are used in the control of insects that are harmful in the adult stage." [ISBN:0721662544]
synonym: "pyrethroid resistance" RELATED []
synonym: "pyrethroid susceptibility/resistance" RELATED []
is_a: GO:0017085 ! response to insecticide

[Term]
id: GO:0046685
name: response to arsenic-containing substance
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides." [GOC:hjd, ISBN:0721662544]
subset: gosubset_prok
synonym: "arsenate sensitivity/resistance" RELATED []
synonym: "response to arsenic" EXACT [GOC:curators]
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0046686
name: response to cadmium ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus." [GOC:ai]
subset: gosubset_prok
synonym: "cadmium sensitivity/resistance" RELATED []
synonym: "response to cadmium" EXACT []
is_a: GO:0010038 ! response to metal ion

[Term]
id: GO:0046687
name: response to chromate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chromate stimulus." [ISBN:0721662544]
subset: gosubset_prok
synonym: "chromate sensitivity/resistance" RELATED []
is_a: GO:0010035 ! response to inorganic substance
is_a: GO:1901700 ! response to oxygen-containing compound
is_a: GO:1990267 ! response to transition metal nanoparticle

[Term]
id: GO:0046688
name: response to copper ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus." [GOC:ai]
subset: gosubset_prok
synonym: "copper sensitivity/resistance" RELATED []
synonym: "response to copper" EXACT []
is_a: GO:0010038 ! response to metal ion
is_a: GO:1990267 ! response to transition metal nanoparticle

[Term]
id: GO:0046689
name: response to mercury ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus." [GOC:ai]
subset: gosubset_prok
synonym: "mercuric sensitivity/resistance" RELATED []
synonym: "response to mercuric ion" NARROW [GOC:mah]
synonym: "response to mercury" EXACT []
is_a: GO:0010038 ! response to metal ion
is_a: GO:1990267 ! response to transition metal nanoparticle

[Term]
id: GO:0046690
name: response to tellurium ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tellurium ion stimulus." [GOC:ai]
subset: gosubset_prok
synonym: "response to tellurium" EXACT []
synonym: "tellurium sensitivity/resistance" RELATED []
is_a: GO:0010035 ! response to inorganic substance

[Term]
id: GO:0046691
name: intracellular canaliculus
namespace: cellular_component
def: "An apical plasma membrane part that forms a narrow enfolded luminal membrane channel, lined with numerous microvilli, that appears to extend into the cytoplasm of the cell. A specialized network of intracellular canaliculi is a characteristic feature of parietal cells of the gastric mucosa in vertebrates." [GOC:mah, ISBN:0721662544, PMID:10700045]
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0016324 ! apical plasma membrane

[Term]
id: GO:0046692
name: sperm competition
namespace: biological_process
def: "Any process that contributes to the success of sperm fertilization in multiply-mated females." [PMID:10885514]
xref: Wikipedia:Sperm_competition
is_a: GO:0044703 ! multi-organism reproductive process
is_a: GO:0044706 ! multi-multicellular organism process
is_a: GO:0048609 ! multicellular organismal reproductive process
relationship: part_of GO:0007320 ! insemination

[Term]
id: GO:0046693
name: sperm storage
namespace: biological_process
def: "The retention of sperm by a female following mating." [PMID:10885514]
synonym: "retention of sperm" EXACT []
synonym: "sequestering of sperm" EXACT []
synonym: "sequestration of sperm" EXACT []
synonym: "sperm retention" EXACT []
synonym: "sperm sequestering" EXACT []
synonym: "sperm sequestration" EXACT []
synonym: "storage of sperm" EXACT []
is_a: GO:0046692 ! sperm competition

[Term]
id: GO:0046694
name: sperm incapacitation
namespace: biological_process
def: "The process in which the use of stored sperm from the first-mating male is inhibited by the seminal fluid of subsequently mating males." [PMID:10440373]
is_a: GO:0046692 ! sperm competition

[Term]
id: GO:0046695
name: SLIK (SAGA-like) complex
namespace: cellular_component
def: "A SAGA-type histone acetyltransferase complex that contains Rtg2 and a smaller form of Spt7 than the fungal SAGA complex, and lacks Spt8. The complex is involved in the yeast retrograde response pathway, which is important for gene expression changes during mitochondrial dysfunction." [PMID:12101232, PMID:12186975, PMID:17337012]
comment: See also the cellular component term 'SAGA complex ; GO:0000124'.
synonym: "SAGA (alt) complex" EXACT []
synonym: "SALSA complex" EXACT []
synonym: "SLIK/SALSA complex" EXACT []
is_a: GO:0070461 ! SAGA-type complex
relationship: has_part GO:0071819 ! DUBm complex

[Term]
id: GO:0046696
name: lipopolysaccharide receptor complex
namespace: cellular_component
def: "A multiprotein complex that consists of at least three proteins, CD14, TLR4, and MD-2, each of which is glycosylated and which functions as a lipopolysaccharide (LPS) receptor that primes the innate immune response against bacterial pathogens." [PMID:11706042, PMID:9665271]
comment: Note that this term should not be used to refer to CD14 alone, but the multiprotein receptor complex that it is part of.
synonym: "LPS receptor complex" EXACT []
is_a: GO:0043235 ! receptor complex
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0016021 ! integral component of membrane

[Term]
id: GO:0046697
name: decidualization
namespace: biological_process
def: "The cellular and vascular changes occurring in the endometrium of the pregnant uterus just after the onset of blastocyst implantation. This process involves the proliferation and differentiation of the fibroblast-like endometrial stromal cells into large, polyploid decidual cells that eventually form the maternal component of the placenta." [ISBN:0721662544, PMID:11133685]
synonym: "decidual cell reaction" EXACT []
xref: Wikipedia:Decidualization
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0009888 ! tissue development
relationship: part_of GO:0001893 ! maternal placenta development
relationship: part_of GO:0007565 ! female pregnancy

[Term]
id: GO:0046700
name: heterocycle catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [GOC:ai]
subset: gosubset_prok
synonym: "heterocycle breakdown" EXACT []
synonym: "heterocycle catabolism" EXACT []
synonym: "heterocycle degradation" EXACT []
is_a: GO:0044248 ! cellular catabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0046701
name: insecticide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of insecticides, chemicals used to kill insects." [GOC:ai]
subset: gosubset_prok
synonym: "insecticide breakdown" EXACT []
synonym: "insecticide catabolism" EXACT []
synonym: "insecticide degradation" EXACT []
is_a: GO:0009407 ! toxin catabolic process
is_a: GO:0017143 ! insecticide metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process

[Term]
id: GO:0046702
name: galactoside 6-L-fucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to a galactoside acceptor molecule, usually an N-glycan, to form an alpha(1,6)-fucosylated galactoside." [PMID:12413479]
is_a: GO:0046921 ! alpha-(1->6)-fucosyltransferase activity

[Term]
id: GO:0046703
name: natural killer cell lectin-like receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a lectin-like natural killer cell receptor." [GOC:ai]
synonym: "KLRC4 receptor binding" NARROW []
synonym: "NK cell lectin-like receptor binding" EXACT []
synonym: "NKG2D receptor binding" NARROW []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0046704
name: CDP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving CDP, cytidine (5'-)diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "CDP metabolism" EXACT []
is_a: GO:0009193 ! pyrimidine ribonucleoside diphosphate metabolic process
is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process
is_a: GO:0046131 ! pyrimidine ribonucleoside metabolic process

[Term]
id: GO:0046705
name: CDP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of CDP, cytidine (5'-)diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "CDP anabolism" EXACT []
synonym: "CDP biosynthesis" EXACT []
synonym: "CDP formation" EXACT []
synonym: "CDP synthesis" EXACT []
is_a: GO:0009194 ! pyrimidine ribonucleoside diphosphate biosynthetic process
is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process
is_a: GO:0046132 ! pyrimidine ribonucleoside biosynthetic process
is_a: GO:0046704 ! CDP metabolic process

[Term]
id: GO:0046706
name: CDP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of CDP, cytidine (5'-)diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "CDP breakdown" EXACT []
synonym: "CDP catabolism" EXACT []
synonym: "CDP degradation" EXACT []
is_a: GO:0009195 ! pyrimidine ribonucleoside diphosphate catabolic process
is_a: GO:0009222 ! pyrimidine ribonucleotide catabolic process
is_a: GO:0046133 ! pyrimidine ribonucleoside catabolic process
is_a: GO:0046704 ! CDP metabolic process

[Term]
id: GO:0046707
name: IDP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving IDP, inosine 5'-diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "IDP metabolism" EXACT []
is_a: GO:0009150 ! purine ribonucleotide metabolic process
is_a: GO:0009179 ! purine ribonucleoside diphosphate metabolic process

[Term]
id: GO:0046708
name: IDP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of IDP, inosine 5'-diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "IDP anabolism" EXACT []
synonym: "IDP biosynthesis" EXACT []
synonym: "IDP formation" EXACT []
synonym: "IDP synthesis" EXACT []
is_a: GO:0009152 ! purine ribonucleotide biosynthetic process
is_a: GO:0009180 ! purine ribonucleoside diphosphate biosynthetic process
is_a: GO:0046707 ! IDP metabolic process

[Term]
id: GO:0046709
name: IDP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of IDP, inosine 5'-diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "IDP breakdown" EXACT []
synonym: "IDP catabolism" EXACT []
synonym: "IDP degradation" EXACT []
is_a: GO:0009154 ! purine ribonucleotide catabolic process
is_a: GO:0009181 ! purine ribonucleoside diphosphate catabolic process
is_a: GO:0046707 ! IDP metabolic process

[Term]
id: GO:0046710
name: GDP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving GDP, guanosine 5'-diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "GDP metabolism" EXACT []
is_a: GO:0009150 ! purine ribonucleotide metabolic process
is_a: GO:0009179 ! purine ribonucleoside diphosphate metabolic process
is_a: GO:1901068 ! guanosine-containing compound metabolic process

[Term]
id: GO:0046711
name: GDP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of GDP, guanosine 5'-diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "GDP anabolism" EXACT []
synonym: "GDP biosynthesis" EXACT []
synonym: "GDP formation" EXACT []
synonym: "GDP synthesis" EXACT []
is_a: GO:0009152 ! purine ribonucleotide biosynthetic process
is_a: GO:0009180 ! purine ribonucleoside diphosphate biosynthetic process
is_a: GO:0046710 ! GDP metabolic process
is_a: GO:1901070 ! guanosine-containing compound biosynthetic process

[Term]
id: GO:0046712
name: GDP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of GDP, guanosine 5'-diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "GDP breakdown" EXACT []
synonym: "GDP catabolism" EXACT []
synonym: "GDP degradation" EXACT []
is_a: GO:0009154 ! purine ribonucleotide catabolic process
is_a: GO:0009181 ! purine ribonucleoside diphosphate catabolic process
is_a: GO:0046710 ! GDP metabolic process
is_a: GO:1901069 ! guanosine-containing compound catabolic process

[Term]
id: GO:0046713
name: borate transport
namespace: biological_process
def: "The directed movement of borate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Borate is the anion (BO3)3-; boron is a group 13 element, with properties which are borderline between metals and non-metals." [CHEBI:22908, GOC:curators, http://www.webelements.com/]
synonym: "boron transport" RELATED [GOC:curators]
is_a: GO:0015698 ! inorganic anion transport

[Term]
id: GO:0046714
name: borate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with borate, the anion (BO3)3-." [CHEBI:22908, GOC:curators]
subset: gosubset_prok
synonym: "boron binding" RELATED [GOC:curators]
is_a: GO:0043168 ! anion binding

[Term]
id: GO:0046715
name: borate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transport of borate across a membrane against the concentration gradient." [PMID:12447444]
subset: gosubset_prok
synonym: "boron transmembrane transporter activity" RELATED [GOC:curators]
synonym: "efflux-type borate transporter" NARROW [GOC:curators]
synonym: "efflux-type boron transporter" RELATED [GOC:curators]
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity
relationship: part_of GO:0035445 ! borate transmembrane transport

[Term]
id: GO:0046716
name: muscle cell cellular homeostasis
namespace: biological_process
def: "The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state." [GOC:mah, PMID:3091429, PMID:7781901]
synonym: "muscle fiber maintenance" NARROW [GOC:dph, GOC:tb]
synonym: "muscle homeostasis" RELATED [GOC:dph]
is_a: GO:0019725 ! cellular homeostasis
is_a: GO:0060249 ! anatomical structure homeostasis

[Term]
id: GO:0046717
name: acid secretion
namespace: biological_process
def: "The controlled release of acid by a cell or a tissue." [GOC:ai]
is_a: GO:0046903 ! secretion

[Term]
id: GO:0046718
name: viral entry into host cell
namespace: biological_process
alt_id: GO:0019063
def: "The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm." [GOC:jl]
comment: Viral attachment to the host cell is not part of viral entry in GO because virus attachment does not always lead to viral entry: attachment can also result in the virion being carried by the host cell to another location.
subset: goslim_virus
subset: virus_checked
synonym: "entry of virus into host cell" EXACT []
synonym: "phage translocation" EXACT []
synonym: "viral penetration" EXACT []
synonym: "virion penetration" EXACT []
synonym: "virion penetration into host cell" EXACT []
synonym: "virus entry into host cell" EXACT [GOC:bf]
xref: Reactome:REACT_6232 "Binding of the influenza virion to the host cell, Homo sapiens"
xref: Reactome:REACT_6282 "Fusion and Uncoating of the Influenza Virion, Homo sapiens"
xref: VZ:936
is_a: GO:0030260 ! entry into host cell
relationship: part_of GO:0019058 ! viral life cycle

[Term]
id: GO:0046719
name: regulation by virus of viral protein levels in host cell
namespace: biological_process
def: "Any virus-mediated process that modulates the levels of viral proteins in a cell." [GOC:ai]
synonym: "regulation of viral protein levels" EXACT []
is_a: GO:0048878 ! chemical homeostasis
is_a: GO:0050792 ! regulation of viral process

[Term]
id: GO:0046720
name: citric acid secretion
namespace: biological_process
def: "The controlled release of citric acid, 2-hydroxy-1,2,3-propanetricarboxylic acid, by a cell or a tissue." [GOC:ai]
synonym: "citrate secretion" EXACT []
is_a: GO:0015746 ! citrate transport
is_a: GO:0046717 ! acid secretion

[Term]
id: GO:0046721
name: formic acid secretion
namespace: biological_process
def: "The controlled release of formic acid, HCOOH, by a cell or a tissue." [GOC:ai]
synonym: "formate secretion" EXACT []
is_a: GO:0015724 ! formate transport
is_a: GO:0046717 ! acid secretion

[Term]
id: GO:0046722
name: lactic acid secretion
namespace: biological_process
def: "The controlled release of lactic acid, 2-hydroxypropanoic acid, by a cell or a tissue." [GOC:ai]
synonym: "lactate secretion" EXACT []
is_a: GO:0035879 ! plasma membrane lactate transport
is_a: GO:0046717 ! acid secretion

[Term]
id: GO:0046723
name: malic acid secretion
namespace: biological_process
def: "The controlled release of malic acid, hydroxybutanedioic (hydroxysuccinic) acid, by a cell or a tissue." [GOC:ai]
synonym: "hydroxysuccinic acid secretion" EXACT []
synonym: "malate secretion" EXACT []
is_a: GO:0015743 ! malate transport
is_a: GO:0046717 ! acid secretion

[Term]
id: GO:0046724
name: oxalic acid secretion
namespace: biological_process
def: "The controlled release of oxalic acid, ethanedioic acid, by a cell or a tissue." [GOC:ai]
synonym: "oxalate secretion" EXACT []
is_a: GO:0019532 ! oxalate transport
is_a: GO:0046717 ! acid secretion

[Term]
id: GO:0046725
name: negative regulation by virus of viral protein levels in host cell
namespace: biological_process
def: "Any process where the infecting virus reduces the levels of viral proteins in a cell." [GOC:ai]
synonym: "down regulation of viral protein levels in host cell" EXACT []
synonym: "down-regulation of viral protein levels in host cell" EXACT []
synonym: "downregulation of viral protein levels in host cell" EXACT []
synonym: "inhibition of viral protein levels in host cell" NARROW []
synonym: "negative regulation of viral protein levels" EXACT []
is_a: GO:0046719 ! regulation by virus of viral protein levels in host cell
is_a: GO:0048525 ! negative regulation of viral process

[Term]
id: GO:0046726
name: positive regulation by virus of viral protein levels in host cell
namespace: biological_process
def: "Any process where the infecting virus increases the levels of viral proteins in a cell." [GOC:ai]
synonym: "activation of viral protein levels in host cell" NARROW []
synonym: "positive regulation of viral protein levels" EXACT []
synonym: "stimulation of viral protein levels in host cell" NARROW []
synonym: "up regulation of viral protein levels in host cell" EXACT []
synonym: "up-regulation of viral protein levels in host cell" EXACT []
synonym: "upregulation of viral protein levels in host cell" EXACT []
is_a: GO:0046719 ! regulation by virus of viral protein levels in host cell
is_a: GO:0048524 ! positive regulation of viral process

[Term]
id: GO:0046727
name: capsomere
namespace: cellular_component
def: "Any of the protein subunits that comprise the closed shell or coat (capsid) of certain viruses." [ISBN:0198506732]
synonym: "capsomer" EXACT []
xref: Wikipedia:Capsomere
is_a: GO:0044423 ! virion part
relationship: part_of GO:0019028 ! viral capsid

[Term]
id: GO:0046729
name: viral procapsid
namespace: cellular_component
def: "A stable empty viral capsid produced during the assembly of viruses." [ISBN:0072370319, ISBN:1555811272]
is_a: GO:0044423 ! virion part

[Term]
id: GO:0046730
name: induction of host immune response by virus
namespace: biological_process
def: "The induction by a virus of an immune response in the host organism." [ISBN:0781802976]
synonym: "activation of host immune response by virus" EXACT []
is_a: GO:0044416 ! induction by symbiont of host defense response
is_a: GO:0075528 ! modulation by virus of host immune response

[Term]
id: GO:0046731
name: passive induction of host immune response by virus
namespace: biological_process
def: "The unintentional stimulation by a virus of a host defense response to viral infection, as part of the viral infectious cycle." [ISBN:0781802976]
synonym: "passive activation of host immune response by virus" EXACT []
synonym: "passive viral induction of host immune response" EXACT []
is_a: GO:0046730 ! induction of host immune response by virus

[Term]
id: GO:0046732
name: active induction of host immune response by virus
namespace: biological_process
def: "The intentional, virally-encoded stimulation of a host defense response to viral infection." [ISBN:0781802976]
synonym: "active viral induction of host immune response" EXACT []
xref: Reactome:REACT_6213 "Influenza Virus Induced Apoptosis, Homo sapiens"
xref: Reactome:REACT_6229 "NA activation of TGF-beta, Homo sapiens"
xref: Reactome:REACT_6243 "PB1-F2 binds to the mitochondrial adenine nucleotide translocator 3 ANT3, inducing apoptosis, Homo sapiens"
is_a: GO:0046730 ! induction of host immune response by virus

[Term]
id: GO:0046733
name: passive induction of host humoral immune response by virus
namespace: biological_process
def: "The unintentional stimulation by a virus of a host humoral defense response to viral infection, as part of the viral infectious cycle." [ISBN:0781802976]
synonym: "passive induction of humoral immune response in host by virus" EXACT []
synonym: "passive viral activation of humoral immune response in host" EXACT []
synonym: "passive viral induction of humoral immune response in host" EXACT []
is_a: GO:0046731 ! passive induction of host immune response by virus

[Term]
id: GO:0046734
name: passive induction of host cell-mediated immune response by virus
namespace: biological_process
def: "The unintentional stimulation by a virus of a cell-mediated host defense response to viral infection, as part of the viral infectious cycle." [ISBN:0781802976]
synonym: "passive induction of cell-mediated immune response in host by virus" EXACT []
synonym: "passive viral activation of cell-mediated immune response in host" EXACT []
synonym: "passive viral induction of cell-mediated immune response in host" EXACT []
is_a: GO:0046731 ! passive induction of host immune response by virus

[Term]
id: GO:0046735
name: passive induction of host innate immune response by virus
namespace: biological_process
def: "The unintentional stimulation by a virus of an innate host defense response to viral infection, as part of the viral infectious cycle." [GOC:go_curators, ISBN:0781802976]
synonym: "passive induction of innate immune response in host by virus" EXACT []
synonym: "passive viral activation of innate immune response in host" EXACT []
synonym: "passive viral induction of innate immune response in host" EXACT []
is_a: GO:0046731 ! passive induction of host immune response by virus

[Term]
id: GO:0046736
name: active induction of humoral immune response in host by virus
namespace: biological_process
def: "The intentional, virally-encoded stimulation of a host humoral defense response to viral infection." [ISBN:0781802976]
synonym: "active viral induction of humoral immune response in host" EXACT []
is_a: GO:0046732 ! active induction of host immune response by virus

[Term]
id: GO:0046737
name: active induction of cell-mediated immune response in host by virus
namespace: biological_process
def: "The intentional, virally-encoded stimulation of a cell-mediated host defense response to viral infection." [ISBN:0781802976]
synonym: "active viral induction of cell-mediated immune response in host" EXACT []
is_a: GO:0046732 ! active induction of host immune response by virus

[Term]
id: GO:0046738
name: active induction of innate immune response in host by virus
namespace: biological_process
def: "The intentional, virally-encoded stimulation of an innate host defense response to viral infection." [ISBN:0781802976]
synonym: "active viral induction of innate immune response in host" EXACT []
is_a: GO:0046732 ! active induction of host immune response by virus

[Term]
id: GO:0046739
name: transport of virus in multicellular host
namespace: biological_process
def: "The transport of a virus between cells in a multicellular organism. The cells can be adjacent or spatially separated (e.g. in different tissues or organs)." [GOC:bf, GOC:jl, ISBN:0781718325]
subset: virus_checked
synonym: "spread of virus in multicellular host" RELATED [GOC:bf, GOC:jl]
synonym: "spread of virus within multicellular host" EXACT []
synonym: "viral spread within multicellular host" EXACT []
is_a: GO:0044000 ! movement in host
is_a: GO:0046794 ! transport of virus

[Term]
id: GO:0046740
name: transport of virus in host, cell to cell
namespace: biological_process
def: "The transport of a virus between adjacent cells in a multicellular organism." [GOC:bf, GOC:jl, ISBN:0781718325]
subset: goslim_virus
subset: virus_checked
synonym: "cell to cell spread of virus within host" EXACT []
synonym: "intercellular virus transport" EXACT [GOC:bf, GOC:jl]
synonym: "spread of virus in host, cell to cell" RELATED [GOC:bf, GOC:jl]
synonym: "spread of virus within host, cell to cell" EXACT []
synonym: "viral spread within host, cell to cell" EXACT []
is_a: GO:0046739 ! transport of virus in multicellular host
is_a: GO:1902586 ! multi-organism intercellular transport

[Term]
id: GO:0046741
name: transport of virus in host, tissue to tissue
namespace: biological_process
def: "The transport of a virus between tissues in a multicellular organism." [GOC:bf, GOC:jl, ISBN:0781718325]
synonym: "spread of virus in host, tissue to tissue" RELATED [GOC:bf, GOC:jl]
synonym: "spread of virus within host, tissue to tissue" EXACT []
synonym: "tissue to tissue spread of virus within host" EXACT []
synonym: "viral spread within host, tissue to tissue" EXACT []
is_a: GO:0046739 ! transport of virus in multicellular host

[Term]
id: GO:0046745
name: viral capsid secondary envelopment
namespace: biological_process
alt_id: GO:0046746
alt_id: GO:0046747
alt_id: GO:0046748
alt_id: GO:0046768
alt_id: GO:0046769
alt_id: GO:0046770
def: "The process in which a capsid acquires another membrane envelope, subsequent to acquiring an initial membrane envelope." [ISBN:0072370319, ISBN:0781718325, PMID:11533156]
synonym: "endoplasmic reticulum membrane viral budding during viral capsid re-envelopment" RELATED []
synonym: "ER membrane viral budding during viral capsid re-envelopment" RELATED []
synonym: "Golgi membrane viral budding during viral capsid re-envelopment" RELATED []
synonym: "inner nuclear membrane viral budding during viral capsid re-envelopment" RELATED []
synonym: "nuclear membrane viral budding during viral capsid re-envelopment" RELATED []
synonym: "outer nuclear membrane viral budding during viral capsid re-envelopment" EXACT []
synonym: "plasma membrane viral budding during viral capsid re-envelopment" RELATED []
synonym: "viral budding from ER membrane by viral capsid re-envelopment" EXACT []
synonym: "viral budding from ER membrane during viral capsid re-envelopment" RELATED []
synonym: "viral budding from Golgi membrane by viral capsid re-envelopment" EXACT []
synonym: "viral budding from Golgi membrane during viral capsid re-envelopment" RELATED []
synonym: "viral budding from inner nuclear membrane by viral capsid re-envelopment" EXACT []
synonym: "viral budding from inner nuclear membrane during viral capsid re-envelopment" RELATED []
synonym: "viral budding from nuclear membrane by viral capsid re-envelopment" EXACT []
synonym: "viral budding from nuclear membrane during viral capsid re-envelopment" RELATED []
synonym: "viral budding from outer nuclear membrane by viral capsid re-envelopment" EXACT []
synonym: "viral budding from outer nuclear membrane during viral capsid re-envelopment" EXACT []
synonym: "viral budding from plasma membrane by viral capsid re-envelopment" EXACT []
synonym: "viral budding from plasma membrane during viral capsid re-envelopment" RELATED []
synonym: "viral capsid re-envelopment" RELATED [GOC:bf, GOC:jl]
synonym: "virus budding from ER membrane by viral capsid re-envelopment" EXACT []
synonym: "virus budding from ER membrane during viral capsid re-envelopment" RELATED [GOC:tb]
synonym: "virus budding from Golgi membrane by viral capsid re-envelopment" EXACT []
synonym: "virus budding from Golgi membrane during viral capsid re-envelopment" RELATED [GOC:tb]
synonym: "virus budding from inner nuclear membrane by viral capsid re-envelopment" EXACT []
synonym: "virus budding from inner nuclear membrane during viral capsid re-envelopment" RELATED [GOC:tb]
synonym: "virus budding from nuclear membrane by viral capsid re-envelopment" EXACT []
synonym: "virus budding from nuclear membrane during viral capsid re-envelopment" RELATED [GOC:tb]
synonym: "virus budding from outer nuclear membrane by viral capsid re-envelopment" EXACT []
synonym: "virus budding from outer nuclear membrane during viral capsid re-envelopment" RELATED [GOC:tb]
synonym: "virus budding from plasma membrane during viral capsid re-envelopment" RELATED [GOC:tb]
is_a: GO:0016032 ! viral process

[Term]
id: GO:0046752
name: viral capsid precursor transport to host cell nucleus
namespace: biological_process
def: "Any process in which viral capsid precursors are transported to a specific location in the nucleus, thus accumulating the necessary components for assembly of a capsid." [ISBN:0781718325]
subset: virus_checked
synonym: "establishment and maintenance of viral capsid precursor localization in nucleus" BROAD []
synonym: "localization of viral capsid precursors in nucleus" BROAD []
synonym: "nuclear localization of viral capsid precursors" BROAD []
synonym: "viral capsid precursor localisation in host cell nucleus" BROAD [GOC:mah]
synonym: "viral capsid precursor localization in host cell nucleus" BROAD [GOC:curators]
synonym: "viral capsid precursor localization to host cell nucleus" BROAD [GOC:bf, GOC:jl]
is_a: GO:0006886 ! intracellular protein transport
is_a: GO:0075733 ! intracellular transport of virus
relationship: part_of GO:0039708 ! nuclear capsid assembly

[Term]
id: GO:0046753
name: non-lytic viral release
namespace: biological_process
def: "The exit of a viral particle from a cell that does not involve cell lysis." [GOC:bf, GOC:jl, ISBN:0072370319]
subset: virus_checked
is_a: GO:0019076 ! viral release from host cell
is_a: GO:0046794 ! transport of virus

[Term]
id: GO:0046754
name: viral exocytosis
namespace: biological_process
def: "The exit of enveloped or unenveloped virion particles from the host cell by exocytosis, without causing cell lysis." [ISBN:0072370319]
is_a: GO:0046753 ! non-lytic viral release

[Term]
id: GO:0046755
name: viral budding
namespace: biological_process
alt_id: GO:0046744
def: "A viral process by which enveloped viruses acquire a host-derived membrane enriched in viral proteins to form their external envelope. The process starts when nucleocapsids, assembled or in the process of being built, induce formation of a membrane curvature in the host plasma or organelle membrane and wrap up in the forming bud. The process ends when the bud is eventually pinched off by membrane scission to release the enveloped particle into the lumenal or extracellular space." [ISBN:0781718325, VZ:1947]
subset: goslim_virus
subset: virus_checked
synonym: "viral capsid envelopment" RELATED []
synonym: "virion budding" NARROW []
synonym: "virus budding" RELATED []
xref: VZ:1947 "Viral budding"
is_a: GO:0016032 ! viral process
is_a: GO:1902592 ! multi-organism membrane budding
relationship: part_of GO:0019058 ! viral life cycle
relationship: part_of GO:0019068 ! virion assembly

[Term]
id: GO:0046757
name: obsolete lytic virus budding from ER membrane
namespace: biological_process
def: "OBSOLETE. A form of viral release in which the nucleocapsid evaginates from the host endoplasmic reticulum membrane system, resulting in envelopment of the virus and cell lysis." [ISBN:0072370319]
comment: This term was made obsolete because it does not appear to correspond to a real biological process.
synonym: "lytic endoplasmic reticulum membrane viral budding" EXACT []
synonym: "lytic ER membrane viral budding" EXACT []
synonym: "lytic viral budding from ER membrane" EXACT []
synonym: "lytic virus budding from ER membrane" EXACT []
is_obsolete: true

[Term]
id: GO:0046758
name: obsolete lytic virus budding from Golgi membrane
namespace: biological_process
def: "OBSOLETE. A form of viral release in which the nucleocapsid evaginates from the host Golgi membrane system, resulting in envelopment of the virus and cell lysis." [ISBN:0072370319]
comment: This term was made obsolete because it does not appear to correspond to a real biological process.
synonym: "lytic Golgi membrane viral budding" EXACT []
synonym: "lytic viral budding from Golgi membrane" EXACT []
synonym: "lytic virus budding from Golgi membrane" EXACT []
is_obsolete: true

[Term]
id: GO:0046759
name: obsolete lytic virus budding from plasma membrane
namespace: biological_process
def: "OBSOLETE. A form of viral release in which the nucleocapsid evaginates from the host nuclear membrane system, resulting in envelopment of the virus and cell lysis." [ISBN:0072370319]
comment: This term was made obsolete because it does not appear to correspond to a real biological process.
synonym: "lytic plasma membrane viral budding" EXACT []
synonym: "lytic viral budding from plasma membrane" EXACT []
synonym: "lytic virus budding from plasma membrane" EXACT []
is_obsolete: true

[Term]
id: GO:0046760
name: viral budding from Golgi membrane
namespace: biological_process
alt_id: GO:0046750
alt_id: GO:0046763
def: "A viral budding that starts with formation of a membrane curvature in the host Golgi membrane." [GOC:bf, ISBN:0072370319, VZ:1947]
subset: virus_checked
synonym: "Golgi membrane viral budding" EXACT []
synonym: "Golgi membrane viral budding during viral capsid envelopment" RELATED []
synonym: "viral budding from Golgi membrane by viral capsid envelopment" RELATED []
synonym: "viral budding from Golgi membrane during viral capsid envelopment" RELATED []
synonym: "virus budding from Golgi membrane" EXACT []
synonym: "virus budding from Golgi membrane by viral capsid envelopment" RELATED []
synonym: "virus budding from Golgi membrane during viral capsid envelopment" RELATED [GOC:tb]
is_a: GO:0046755 ! viral budding

[Term]
id: GO:0046761
name: viral budding from plasma membrane
namespace: biological_process
alt_id: GO:0046766
alt_id: GO:0046767
def: "A viral budding that starts with formation of a membrane curvature in the host plasma membrane." [GOC:bf, ISBN:0072370319, PMID:9394621, VZ:1947]
subset: virus_checked
synonym: "plasma membrane viral budding" EXACT []
synonym: "plasma membrane viral budding during viral capsid envelopment" RELATED []
synonym: "viral budding from plasma membrane by viral capsid envelopment" RELATED []
synonym: "viral budding from plasma membrane during viral capsid envelopment" RELATED []
synonym: "virus budding from plasma membrane" EXACT []
synonym: "virus budding from plasma membrane by viral capsid envelopment" EXACT []
synonym: "virus budding from plasma membrane during viral capsid envelopment" RELATED [GOC:tb]
xref: Reactome:REACT_6193 "Membrane fusion, Homo sapiens"
is_a: GO:0046753 ! non-lytic viral release
is_a: GO:0046755 ! viral budding

[Term]
id: GO:0046762
name: viral budding from ER membrane
namespace: biological_process
alt_id: GO:0046751
alt_id: GO:0046764
def: "A viral budding that starts with formation of a membrane curvature in the host ER membrane." [GOC:bf, GOC:jl, ISBN:0072370319, VZ:1947]
subset: virus_checked
synonym: "endoplasmic reticulum membrane viral budding" EXACT []
synonym: "endoplasmic reticulum membrane viral budding during viral capsid envelopment" RELATED []
synonym: "ER membrane viral budding" EXACT []
synonym: "ER membrane viral budding during viral capsid envelopment" RELATED []
synonym: "viral budding from ER membrane by viral capsid envelopment" RELATED []
synonym: "viral budding from ER membrane during viral capsid envelopment" RELATED []
synonym: "virus budding from ER membrane" EXACT []
synonym: "virus budding from ER membrane by viral capsid envelopment" EXACT []
synonym: "virus budding from ER membrane during viral capsid envelopment" RELATED [GOC:tb]
is_a: GO:0046755 ! viral budding

[Term]
id: GO:0046765
name: viral budding from nuclear membrane
namespace: biological_process
alt_id: GO:0046749
def: "A viral budding that starts with formation of a membrane curvature in the host nuclear membrane." [GOC:bf, ISBN:0072370319]
synonym: "nuclear membrane viral budding" EXACT []
synonym: "nuclear membrane viral budding during viral capsid envelopment" RELATED []
synonym: "viral budding from nuclear membrane by viral capsid envelopment" RELATED []
synonym: "viral budding from nuclear membrane during viral capsid envelopment" RELATED []
synonym: "virus budding from nuclear membrane" EXACT []
synonym: "virus budding from nuclear membrane by viral capsid envelopment" EXACT []
synonym: "virus budding from nuclear membrane during viral capsid envelopment" RELATED [GOC:tb]
is_a: GO:0046755 ! viral budding
relationship: part_of GO:0046802 ! exit of virus from host cell nucleus by nuclear egress

[Term]
id: GO:0046771
name: viral budding from inner nuclear membrane
namespace: biological_process
def: "The envelopment of a virus, in which the nucleocapsid evaginates from the host inner nuclear membrane system into the perinuclear space, thus acquiring a membrane envelope." [ISBN:0072370319]
synonym: "inner nuclear membrane viral budding during viral capsid envelopment" RELATED []
synonym: "viral budding from inner nuclear membrane by viral capsid envelopment" RELATED []
synonym: "viral budding from inner nuclear membrane during viral capsid envelopment" RELATED []
synonym: "virus budding from inner nuclear membrane by viral capsid envelopment" EXACT []
synonym: "virus budding from inner nuclear membrane during viral capsid envelopment" RELATED [GOC:tb]
is_a: GO:0046765 ! viral budding from nuclear membrane

[Term]
id: GO:0046772
name: viral budding from outer nuclear membrane
namespace: biological_process
def: "The envelopment of a virus, in which the nucleocapsid evaginates from the host outer nuclear membrane system, thus acquiring a membrane envelope." [ISBN:0072370319]
synonym: "outer nuclear membrane viral budding during viral capsid envelopment" RELATED []
synonym: "viral budding from outer nuclear membrane during viral capsid envelopment" RELATED []
synonym: "virus budding from outer nuclear membrane by viral capsid envelopment" EXACT []
synonym: "virus budding from outer nuclear membrane during viral capsid envelopment" RELATED [GOC:tb]
is_a: GO:0046765 ! viral budding from nuclear membrane

[Term]
id: GO:0046773
name: suppression by virus of host translation termination
namespace: biological_process
def: "Any viral process that stops, prevents, or reduces the frequency, rate or extent of translational termination of a host mRNA." [ISBN:0781718325]
synonym: "negative regulation by virus of host cell protein biosynthesis shutoff" EXACT []
synonym: "negative regulation by virus of host cell protein biosynthetic process shutoff" EXACT []
synonym: "suppression by virus of host termination of protein biosynthetic process" RELATED []
synonym: "viral inhibition of host cell protein biosynthesis shutoff" EXACT []
synonym: "viral inhibition of host cell protein biosynthetic process shutoff" EXACT []
synonym: "viral inhibition of termination of host cell protein biosynthesis" EXACT []
synonym: "viral inhibition of termination of host cell protein biosynthetic process" EXACT []
synonym: "viral suppression of termination by host of host cell protein biosynthesis" EXACT []
synonym: "viral suppression of termination by host of host cell protein biosynthetic process" EXACT []
is_a: GO:0006451 ! translational readthrough
is_a: GO:0019057 ! modulation by virus of host translation
is_a: GO:0044034 ! multi-organism biosynthetic process
is_a: GO:0045904 ! negative regulation of translational termination
intersection_of: GO:0019054 ! modulation by virus of host process
intersection_of: negatively_regulates GO:0006415 ! translational termination
relationship: negatively_regulates GO:0006415 ! translational termination

[Term]
id: GO:0046774
name: suppression by virus of host intracellular interferon activity
namespace: biological_process
def: "Any viral process that results in the inhibition of interferon activity within the host cell." [PMID:10859382]
synonym: "negative regulation by virus of intracellular interferon activity" EXACT []
synonym: "suppression by virus of intracellular interferon activity in host" EXACT []
is_a: GO:0030683 ! evasion or tolerance by virus of host immune response
is_a: GO:0075528 ! modulation by virus of host immune response

[Term]
id: GO:0046775
name: suppression by virus of host cytokine production
namespace: biological_process
def: "Any viral process that results in the inhibition of host cell cytokine production." [PMID:10859382]
synonym: "negative regulation by virus of host cytokine production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0044831 ! modulation by virus of host cytokine production
is_a: GO:0052261 ! suppression of defense response of other organism involved in symbiotic interaction
is_a: GO:0052562 ! negative regulation by symbiont of host immune response
intersection_of: GO:0019054 ! modulation by virus of host process
intersection_of: negatively_regulates GO:0001816 ! cytokine production
relationship: negatively_regulates GO:0001816 ! cytokine production

[Term]
id: GO:0046776
name: suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I
namespace: biological_process
def: "Any viral process that inhibits a host antigen-presenting cell expressing a peptide antigen on its cell surface in association with an MHC class I protein complex. Class I here refers to classical class I molecules." [GOC:add, GOC:bf, PMID:10859382, UniProtKB-KW:KW-1115, VZ:819]
synonym: "inhibition of host MHC class I molecule presentation by virus" EXACT [UniProtKB-KW:KW-1115]
synonym: "major histocompatibility complex" RELATED []
synonym: "negative regulation by virus of MHC class I cell surface presentation" EXACT []
synonym: "suppression by virus of host MHC class I cell surface presentation" EXACT [GOC:add]
synonym: "suppression by virus of MHC class I cell surface presentation in host" EXACT []
xref: VZ:819 "Inhibition of host MHC class I molecule presentation by virus"
is_a: GO:0002590 ! negative regulation of antigen processing and presentation of peptide antigen via MHC class I
is_a: GO:0039588 ! suppression by virus of host antigen processing and presentation
intersection_of: GO:0019054 ! modulation by virus of host process
intersection_of: negatively_regulates GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I
relationship: negatively_regulates GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I

[Term]
id: GO:0046777
name: protein autophosphorylation
namespace: biological_process
def: "The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation)." [ISBN:0198506732]
subset: gosubset_prok
synonym: "protein amino acid autophosphorylation" EXACT [GOC:bf]
xref: Reactome:REACT_100311 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Canis familiaris"
xref: Reactome:REACT_100519 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Bos taurus"
xref: Reactome:REACT_106599 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Xenopus tropicalis"
xref: Reactome:REACT_108394 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Danio rerio"
xref: Reactome:REACT_1116 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Homo sapiens"
xref: Reactome:REACT_30997 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Rattus norvegicus"
xref: Reactome:REACT_80689 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Oryza sativa"
xref: Reactome:REACT_80700 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Sus scrofa"
xref: Reactome:REACT_83436 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Arabidopsis thaliana"
xref: Reactome:REACT_83727 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Gallus gallus"
xref: Reactome:REACT_85871 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Mus musculus"
xref: Reactome:REACT_88668 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Drosophila melanogaster"
xref: Reactome:REACT_98066 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Saccharomyces cerevisiae"
xref: Reactome:REACT_99025 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Taeniopygia guttata"
xref: Reactome:REACT_99966 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Schizosaccharomyces pombe"
xref: Wikipedia:Autophosphorylation
is_a: GO:0006468 ! protein phosphorylation

[Term]
id: GO:0046778
name: modification by virus of host mRNA processing
namespace: biological_process
def: "Any viral process that interferes with the processing of mRNA in the host cell." [ISBN:0781718325]
synonym: "viral perturbation of host mRNA processing" EXACT []
xref: Reactome:REACT_6168 "Binding of NS1 to cleavage and host polyadenylation specificity factor (CPSF), Homo sapiens"
xref: Reactome:REACT_6173 "Inhibition of Host mRNA Processing and RNA Silencing, Homo sapiens"
xref: Reactome:REACT_6287 "Binding of NS1 to poly(A)-binding protein II (PABII), Homo sapiens"
is_a: GO:0039656 ! modulation by virus of host gene expression
is_a: GO:0050684 ! regulation of mRNA processing

[Term]
id: GO:0046779
name: suppression by virus of expression of host genes with introns
namespace: biological_process
def: "Any viral process that discriminates against and subsequently inhibits host transcripts containing introns, thus allowing only intronless viral mRNA to be fully processed." [PMID:11598019]
synonym: "negative regulation by virus of expression of host genes with introns" EXACT []
synonym: "viral inhibition of expression of host genes with introns" EXACT []
is_a: GO:0039653 ! suppression by virus of host transcription

[Term]
id: GO:0046780
name: suppression by virus of host mRNA splicing
namespace: biological_process
alt_id: GO:0046781
def: "Any viral process that inhibits the splicing of host mRNA, thus reducing host protein production." [ISBN:0781718325, PMID:19729513]
synonym: "negative regulation by virus of host mRNA splicing" EXACT []
synonym: "suppression by virus of host splicing factor activity" EXACT []
synonym: "viral dispersion of host splicing factors" EXACT []
synonym: "viral inhibition of host mRNA splicing" EXACT []
is_a: GO:0033119 ! negative regulation of RNA splicing
is_a: GO:0039524 ! suppression by virus of host mRNA processing

[Term]
id: GO:0046782
name: regulation of viral transcription
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the transcription of the viral genome." [GOC:ai]
is_a: GO:0010468 ! regulation of gene expression
is_a: GO:1903900 ! regulation of viral life cycle
is_a: GO:2001141 ! regulation of RNA biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019083 ! viral transcription
relationship: regulates GO:0019083 ! viral transcription

[Term]
id: GO:0046783
name: modification by virus of host polysomes
namespace: biological_process
def: "Any viral process that interferes with and inhibits the assembly and function of polysomes." [PMID:10438802]
comment: See also the cellular component term 'polysome ; GO:0005844'.
synonym: "viral perturbation of polysomes" EXACT []
is_a: GO:0019057 ! modulation by virus of host translation

[Term]
id: GO:0046784
name: viral mRNA export from host cell nucleus
namespace: biological_process
def: "The directed movement of intronless viral mRNA from the host nucleus to the cytoplasm for translation." [PMID:11598019]
subset: virus_checked
synonym: "intronless viral mRNA export from host cell nucleus" EXACT []
synonym: "intronless viral mRNA export from host nucleus" RELATED []
synonym: "intronless viral mRNA export out of nucleus" EXACT []
synonym: "intronless viral mRNA transport from nucleus to cytoplasm" EXACT []
synonym: "intronless viral mRNA-nucleus export" EXACT []
is_a: GO:0006406 ! mRNA export from nucleus
is_a: GO:0075733 ! intracellular transport of virus

[Term]
id: GO:0046785
name: microtubule polymerization
namespace: biological_process
def: "The addition of tubulin heterodimers to one or both ends of a microtubule." [GOC:ai, GOC:go_curators]
synonym: "microtubule assembly" EXACT []
synonym: "microtubule formation" RELATED []
is_a: GO:0031109 ! microtubule polymerization or depolymerization
is_a: GO:0051258 ! protein polymerization

[Term]
id: GO:0046786
name: viral replication complex formation and maintenance
namespace: biological_process
def: "The process of organizing and assembling viral replication proteins in preparation for viral replication." [ISBN:0781718325]
is_a: GO:0016032 ! viral process
relationship: part_of GO:0019079 ! viral genome replication

[Term]
id: GO:0046787
name: viral DNA repair
namespace: biological_process
def: "The process of restoring viral DNA after damage or errors in replication." [ISBN:0781718325]
is_a: GO:0006281 ! DNA repair
relationship: part_of GO:0016032 ! viral process

[Term]
id: GO:0046789
name: host cell surface receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a receptor on the host cell surface." [GOC:ai, PMID:11511370]
subset: goslim_chembl
subset: gosubset_prok
synonym: "cell surface antigen activity, host-interacting" RELATED []
synonym: "cell surface receptor ligand" RELATED []
is_a: GO:0005102 ! receptor binding
is_a: GO:0046812 ! host cell surface binding

[Term]
id: GO:0046790
name: virion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a virion, either by binding to components of the capsid or the viral envelope." [GOC:ai]
is_a: GO:0005488 ! binding

[Term]
id: GO:0046791
name: obsolete suppression by virus of host complement neutralization
namespace: biological_process
def: "OBSOLETE. Any viral process that results in the inhibition of complement neutralization of the host cell." [PMID:10587354]
comment: This term was made obsolete because the meaning of the term is unclear. It most likely refers to inhibiting the process by which a virus particle is neutralized by the host cell in a complement-dependent manner.
synonym: "negative regulation by virus of host complement neutralization" EXACT []
synonym: "suppression by virus of host complement neutralization" EXACT []
is_obsolete: true

[Term]
id: GO:0046792
name: suppression by virus of host cell cycle arrest
namespace: biological_process
def: "Viral interference in host cell processes that lead cell cycle arrest, allowing cell division to occur." [PMID:9371605]
synonym: "negative regulation by virus of cell cycle arrest" EXACT []
synonym: "viral inhibition of cell cycle arrest" EXACT []
is_a: GO:0019055 ! modification by virus of host cell cycle regulation

[Term]
id: GO:0046793
name: induction by virus of phosphorylation of host RNA polymerase II
namespace: biological_process
def: "Any process in which a virus activates the frequency, rate or extent of phosphorylation of host RNA polymerase II." [PMID:7637000]
synonym: "induction by virus of modification of host RNA polymerase II" BROAD [GOC:bf, GOC:jl]
synonym: "virus-induced modification of host RNA polymerase II" EXACT []
is_a: GO:0019056 ! modulation by virus of host transcription
is_a: GO:0039614 ! induction by virus of host protein phosphorylation

[Term]
id: GO:0046794
name: transport of virus
namespace: biological_process
def: "The directed movement of a virus, or part of a virus, into, out of, or within a host cell." [GOC:ai]
subset: goslim_pir
subset: virus_checked
synonym: "viral transport" EXACT [GOC:bf, GOC:jl]
synonym: "virion transport" NARROW [GOC:bf, GOC:jl]
is_a: GO:0016032 ! viral process
is_a: GO:0044766 ! multi-organism transport

[Term]
id: GO:0046797
name: viral procapsid maturation
namespace: biological_process
def: "The refolding and structural rearrangements of individual capsid subunits to transition from the intermediate procapsid, to the more stable capsid structure." [GOC:bf, PMID:10627558, PMID:19204733]
subset: virus_checked
synonym: "capsid maturation" EXACT [UniProtKB-KW:KW-0917]
synonym: "viral capsid maturation" EXACT [PMID:19204733]
synonym: "virion maturation" BROAD [UniProtKB-KW:KW-0917]
is_a: GO:0022607 ! cellular component assembly
relationship: part_of GO:0019069 ! viral capsid assembly
relationship: part_of GO:0019075 ! virus maturation

[Term]
id: GO:0046798
name: viral portal complex
namespace: cellular_component
def: "A multimeric ring of proteins through which the DNA enters and exits the viral capsid." [PMID:11602732]
is_a: GO:0043234 ! protein complex
is_a: GO:0044423 ! virion part
relationship: part_of GO:0019028 ! viral capsid

[Term]
id: GO:0046799
name: recruitment of helicase-primase complex to DNA lesions
namespace: biological_process
def: "The recruitment of the helicase-primase complex to viral DNA lesions during viral DNA repair." [ISBN:0781718325]
is_a: GO:0016032 ! viral process
relationship: part_of GO:0046787 ! viral DNA repair

[Term]
id: GO:0046800
name: obsolete enhancement of virulence
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the severity of viral infection and subsequent disease." [PMID:10587354]
comment: This term was made obsolete because 'virulence' is not a biological process; however, alteration of virulence also does not fit under 'regulation of biological quality ; GO:0065008' because it is a product both of the genotype/phenotype of the infecting organism and the genotype/phenotype of the organism being infected and varies by individual within a species both for the infecting organism and the infected organism.
synonym: "enhancement of virulence" EXACT []
is_obsolete: true

[Term]
id: GO:0046802
name: exit of virus from host cell nucleus by nuclear egress
namespace: biological_process
alt_id: GO:0039676
def: "The directed movement of an assembled viral particle out of the host cell nucleus by budding and fusion through the nuclear membranes. In this process, enveloped viral particles are formed by budding through the inner nuclear membrane. These perinuclear enveloped particles then fuse with the outer nuclear membrane to deliver a naked capsid into the host cytoplasm." [PMID:21494278, PMID:22858153, PMID:9601512, PMID:9765421, VZ:1952]
subset: virus_checked
synonym: "capsid egress" EXACT [VZ:2177]
synonym: "egress of viral procapsid from host cell nucleus" RELATED []
synonym: "nuclear egress" EXACT [PMID:22858153]
synonym: "nuclear egress of viral procapsid" EXACT []
xref: VZ:1952 "Nuclear egress"
is_a: GO:0039674 ! exit of virus from host cell nucleus

[Term]
id: GO:0046803
name: obsolete reduction of virulence
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the severity of viral infection and subsequent disease." [PMID:10982346]
comment: This term was made obsolete because 'virulence' is not a biological process; however, alteration of virulence also does not fit under 'regulation of biological quality ; GO:0065008' because it is a product both of the genotype/phenotype of the infecting organism and the genotype/phenotype of the organism being infected and varies by individual within a species both for the infecting organism and the infected organism.
synonym: "reduction of virulence" EXACT []
is_obsolete: true

[Term]
id: GO:0046804
name: peptide cross-linking via (2S,3S,4Xi,6R)-3-methyl-lanthionine sulfoxide
namespace: biological_process
def: "The formation of a protein-protein cross-link between peptidyl-threonine and peptidyl-cysteine by the synthesis of (2S,3S,4Xi,6R)-3-methyl-lanthionine sulfoxide (3-methyl-L-lanthionine sulfoxide), as found in the antibiotic actagardine." [RESID:AA0330]
subset: gosubset_prok
synonym: "peptide cross-linking via (2S,3S,4Xi,6R)-3-methyl-lanthionine sulphoxide" EXACT []
xref: RESID:AA0330
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018210 ! peptidyl-threonine modification

[Term]
id: GO:0046805
name: protein-heme linkage via 1'-L-histidine
namespace: biological_process
def: "The covalent linkage of heme and a protein via 1'-L-histidine (otherwise known as tau-heme-histidine, tele-heme-histidine)." [RESID:AA0329]
subset: gosubset_prok
synonym: "protein-haem linkage via 1'-L-histidine" EXACT []
xref: RESID:AA0329
is_a: GO:0017003 ! protein-heme linkage
is_a: GO:0017004 ! cytochrome complex assembly

[Term]
id: GO:0046806
name: viral scaffold
namespace: cellular_component
def: "A complex of proteins that form a scaffold around which the viral capsid is constructed." [ISBN:0072370319]
is_a: GO:0043234 ! protein complex
is_a: GO:0044423 ! virion part
relationship: part_of GO:0019028 ! viral capsid

[Term]
id: GO:0046807
name: viral scaffold assembly and maintenance
namespace: biological_process
def: "The assembly and maintenance of the viral scaffold around which the viral capsid is constructed." [ISBN:0072370319]
comment: See also the cellular component term 'viral scaffold ; GO:0046806'.
subset: virus_checked
is_a: GO:0006461 ! protein complex assembly
is_a: GO:0016032 ! viral process
relationship: part_of GO:0019069 ! viral capsid assembly

[Term]
id: GO:0046808
name: assemblon
namespace: cellular_component
def: "Antigenically dense structures located at the periphery of nuclei, close to but not abutting nuclear membranes. Assemblons contain the proteins for immature-capsid assembly; they are located at the periphery of a diffuse structure composed of proteins involved in DNA synthesis, which overlaps only minimally with the assemblons. More than one site can be present simultaneously." [PMID:8676489]
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0046809
name: replication compartment
namespace: cellular_component
def: "Globular nuclear domains where the transcription and replication of the viral genome occurs. More than one site can be present simultaneously." [PMID:9499108, VZ:1951]
synonym: "RC" EXACT [VZ:1951]
is_a: GO:0039715 ! nuclear viral factory

[Term]
id: GO:0046810
name: host cell extracellular matrix binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the extracellular matrix of a host cell." [PMID:7996163]
subset: gosubset_prok
is_a: GO:0050840 ! extracellular matrix binding

[Term]
id: GO:0046811
name: histone deacetylase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of histone deacetylase, which catalyzes of the removal of acetyl groups from histones, proteins complexed to DNA in chromatin and chromosomes." [GOC:ai, PMID:10482575]
is_a: GO:0004857 ! enzyme inhibitor activity
is_a: GO:0035033 ! histone deacetylase regulator activity
relationship: negatively_regulates GO:0004407 ! histone deacetylase activity
relationship: part_of GO:0031064 ! negative regulation of histone deacetylation

[Term]
id: GO:0046812
name: host cell surface binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the surface of a host cell." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0046813
name: receptor-mediated virion attachment to host cell
namespace: biological_process
def: "The process by which a virion attaches to a host cell by binding to a receptor on the host cell surface." [ISBN:0879694971]
subset: virus_checked
synonym: "virion attachment, binding of host cell surface receptor" EXACT [GOC:bf, GOC:jl]
is_a: GO:0019062 ! virion attachment to host cell
relationship: has_part GO:0005102 ! receptor binding

[Term]
id: GO:0046814
name: coreceptor-mediated virion attachment to host cell
namespace: biological_process
def: "The process by which a virion attaches to a host cell by binding to a co-receptor on the host cell surface." [ISBN:0879694971]
subset: virus_checked
synonym: "virion attachment, binding of host cell surface coreceptor" EXACT [GOC:bf, GOC:jl]
is_a: GO:0019062 ! virion attachment to host cell
relationship: has_part GO:0039706 ! co-receptor binding

[Term]
id: GO:0046815
name: genome retention in viral capsid
namespace: biological_process
def: "Any process in which the viral genome is retained within the capsid during genome cleavage and packaging." [PMID:9696839]
is_a: GO:0016032 ! viral process
relationship: part_of GO:0019079 ! viral genome replication

[Term]
id: GO:0046816
name: virion transport vesicle
namespace: cellular_component
def: "A vesicle used to transport the partial or complete virion between cellular compartments." [GOC:vesicles, PMID:7933124]
is_a: GO:0097708 ! intracellular vesicle

[Term]
id: GO:0046817
name: chemokine receptor antagonist activity
namespace: molecular_function
def: "Interacts with chemokine receptors to reduce the action of a chemokine." [GOC:ai, ISBN:0781718325]
is_a: GO:0048019 ! receptor antagonist activity
relationship: part_of GO:0070100 ! negative regulation of chemokine-mediated signaling pathway

[Term]
id: GO:0046818
name: dense nuclear body
namespace: cellular_component
def: "A location in the host cell nucleus where viral proteins colocalize late in infection prior to the onset of viral DNA synthesis. More than one site can be present simultaneously." [PMID:10233976]
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0046819
name: protein secretion by the type V secretion system
namespace: biological_process
def: "The process in which proteins mediate their own secretion across the outer membrane through a beta-barrel pore structure formed by the C-terminal domain of the protein precursor. Following passage across the outer membrane, the mature protein is released from the pore by an autocatalytic activity. Proteins secreted by the Type V system are first translocated across the plasma membrane by the Sec pathway." [GOC:pamgo_curators]
subset: gosubset_prok
synonym: "autotransporter system" EXACT []
synonym: "protein secretion by the autotransporter system" EXACT []
synonym: "protein secretion by the type V protein secretion system" EXACT []
synonym: "type V protein secretion system" EXACT []
is_a: GO:0009306 ! protein secretion
is_a: GO:0098776 ! protein transport across the cell outer membrane

[Term]
id: GO:0046820
name: 4-amino-4-deoxychorismate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamine + chorismate = 4-amino-4-deoxychorismate + L-glutamate. It is composed of two enzymatic activities (which may be present on one or two polypeptides); the first is a glutaminase which yields ammonia from glutamine, releasing glutamate. The ammonia is used by the second activity which catalyzes the amination of chorismate to form 4-amino-4-deoxychorismate." [EC:2.6.1.85, RHEA:11675]
comment: Note that the name 'para-aminobenzoic acid synthase' was initially given to the 'aminodeoxychorismate synthase' activity before the additional 4-amino-4-deoxychorismate lyase activity was discovered. It is the lyase activity that actually produces para-aminobenzoic acid from 4-amino-4-deoxychorismate.
subset: gosubset_prok
synonym: "ADC synthase activity" EXACT [EC:2.6.1.85]
synonym: "aminodeoxychorismate synthase activity" RELATED []
synonym: "chorismate:L-glutamine amido-ligase activity" EXACT [EC:2.6.1.85]
synonym: "p-aminobenzoate synthetase" RELATED []
synonym: "PabB activity" RELATED [EC:2.6.1.85]
synonym: "para-aminobenzoic acid (PABA) synthase" RELATED []
synonym: "para-aminobenzoic acid synthase activity" RELATED []
xref: EC:2.6.1.85
xref: KEGG:R01716
xref: MetaCyc:PABASYN-RXN
xref: RHEA:11675
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0046821
name: extrachromosomal DNA
namespace: cellular_component
def: "DNA structures that are not part of a chromosome." [GOC:ai]
subset: gosubset_prok
xref: Wikipedia:Extrachromosomal_DNA
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0046822
name: regulation of nucleocytoplasmic transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm." [GOC:bf]
is_a: GO:1903649 ! regulation of cytoplasmic transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006913 ! nucleocytoplasmic transport
relationship: regulates GO:0006913 ! nucleocytoplasmic transport

[Term]
id: GO:0046823
name: negative regulation of nucleocytoplasmic transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances between the cytoplasm and the nucleus." [GOC:bf]
synonym: "down regulation of nucleocytoplasmic transport" EXACT []
synonym: "down-regulation of nucleocytoplasmic transport" EXACT []
synonym: "downregulation of nucleocytoplasmic transport" EXACT []
synonym: "inhibition of nucleocytoplasmic transport" NARROW []
is_a: GO:0046822 ! regulation of nucleocytoplasmic transport
is_a: GO:1903650 ! negative regulation of cytoplasmic transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006913 ! nucleocytoplasmic transport
relationship: negatively_regulates GO:0006913 ! nucleocytoplasmic transport

[Term]
id: GO:0046824
name: positive regulation of nucleocytoplasmic transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm." [GOC:bf]
synonym: "activation of nucleocytoplasmic transport" NARROW []
synonym: "stimulation of nucleocytoplasmic transport" NARROW []
synonym: "up regulation of nucleocytoplasmic transport" EXACT []
synonym: "up-regulation of nucleocytoplasmic transport" EXACT []
synonym: "upregulation of nucleocytoplasmic transport" EXACT []
is_a: GO:0046822 ! regulation of nucleocytoplasmic transport
is_a: GO:1903651 ! positive regulation of cytoplasmic transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006913 ! nucleocytoplasmic transport
relationship: positively_regulates GO:0006913 ! nucleocytoplasmic transport

[Term]
id: GO:0046825
name: regulation of protein export from nucleus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of proteins from the nucleus to the cytoplasm." [GOC:bf]
synonym: "regulation of protein export from cell nucleus" EXACT []
synonym: "regulation of protein export out of nucleus" EXACT []
synonym: "regulation of protein transport from nucleus to cytoplasm" EXACT []
synonym: "regulation of protein-nucleus export" EXACT []
is_a: GO:0033157 ! regulation of intracellular protein transport
is_a: GO:0046822 ! regulation of nucleocytoplasmic transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006611 ! protein export from nucleus
relationship: regulates GO:0006611 ! protein export from nucleus

[Term]
id: GO:0046826
name: negative regulation of protein export from nucleus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of proteins from the nucleus into the cytoplasm." [GOC:bf]
synonym: "down regulation of protein export from nucleus" EXACT []
synonym: "down-regulation of protein export from nucleus" EXACT []
synonym: "downregulation of protein export from nucleus" EXACT []
synonym: "inhibition of protein export from nucleus" NARROW []
synonym: "negative regulation of protein export from cell nucleus" EXACT []
synonym: "negative regulation of protein export out of nucleus" EXACT []
synonym: "negative regulation of protein transport from nucleus to cytoplasm" EXACT []
synonym: "negative regulation of protein-nucleus export" EXACT []
is_a: GO:0046823 ! negative regulation of nucleocytoplasmic transport
is_a: GO:0046825 ! regulation of protein export from nucleus
is_a: GO:0090317 ! negative regulation of intracellular protein transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006611 ! protein export from nucleus
relationship: negatively_regulates GO:0006611 ! protein export from nucleus

[Term]
id: GO:0046827
name: positive regulation of protein export from nucleus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm." [GOC:bf]
synonym: "activation of protein export from nucleus" NARROW []
synonym: "positive regulation of protein export from cell nucleus" EXACT []
synonym: "positive regulation of protein export out of nucleus" EXACT []
synonym: "positive regulation of protein transport from nucleus to cytoplasm" EXACT []
synonym: "positive regulation of protein-nucleus export" EXACT []
synonym: "stimulation of protein export from nucleus" NARROW []
synonym: "up regulation of protein export from nucleus" EXACT []
synonym: "up-regulation of protein export from nucleus" EXACT []
synonym: "upregulation of protein export from nucleus" EXACT []
is_a: GO:0046824 ! positive regulation of nucleocytoplasmic transport
is_a: GO:0046825 ! regulation of protein export from nucleus
is_a: GO:0090316 ! positive regulation of intracellular protein transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006611 ! protein export from nucleus
relationship: positively_regulates GO:0006611 ! protein export from nucleus

[Term]
id: GO:0046828
name: regulation of RNA import into nucleus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of movement of RNA from the cytoplasm to the nucleus." [GOC:bf]
synonym: "regulation of RNA import into cell nucleus" EXACT []
synonym: "regulation of RNA transport from cytoplasm to nucleus" EXACT []
synonym: "regulation of RNA-nucleus import" EXACT []
is_a: GO:0032239 ! regulation of nucleobase-containing compound transport
is_a: GO:0046822 ! regulation of nucleocytoplasmic transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006404 ! RNA import into nucleus
relationship: regulates GO:0006404 ! RNA import into nucleus

[Term]
id: GO:0046829
name: negative regulation of RNA import into nucleus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of RNA from the cytoplasm into the nucleus." [GOC:bf]
synonym: "down regulation of RNA import into nucleus" EXACT []
synonym: "down-regulation of RNA import into nucleus" EXACT []
synonym: "downregulation of RNA import into nucleus" EXACT []
synonym: "inhibition of RNA import into nucleus" NARROW []
synonym: "negative regulation of RNA import into cell nucleus" EXACT []
synonym: "negative regulation of RNA transport from cytoplasm to nucleus" EXACT []
synonym: "negative regulation of RNA-nucleus import" EXACT []
is_a: GO:0032240 ! negative regulation of nucleobase-containing compound transport
is_a: GO:0046823 ! negative regulation of nucleocytoplasmic transport
is_a: GO:0046828 ! regulation of RNA import into nucleus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006404 ! RNA import into nucleus
relationship: negatively_regulates GO:0006404 ! RNA import into nucleus

[Term]
id: GO:0046830
name: positive regulation of RNA import into nucleus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of movement of RNA from the cytoplasm into the nucleus." [GOC:bf]
synonym: "activation of RNA import into nucleus" NARROW []
synonym: "positive regulation of RNA import into cell nucleus" EXACT []
synonym: "positive regulation of RNA transport from cytoplasm to nucleus" EXACT []
synonym: "positive regulation of RNA-nucleus import" EXACT []
synonym: "stimulation of RNA import into nucleus" NARROW []
synonym: "up regulation of RNA import into nucleus" EXACT []
synonym: "up-regulation of RNA import into nucleus" EXACT []
synonym: "upregulation of RNA import into nucleus" EXACT []
is_a: GO:0032241 ! positive regulation of nucleobase-containing compound transport
is_a: GO:0046824 ! positive regulation of nucleocytoplasmic transport
is_a: GO:0046828 ! regulation of RNA import into nucleus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006404 ! RNA import into nucleus
relationship: positively_regulates GO:0006404 ! RNA import into nucleus

[Term]
id: GO:0046831
name: regulation of RNA export from nucleus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of RNA from the nucleus to the cytoplasm." [GOC:bf]
synonym: "regulation of RNA export from cell nucleus" EXACT []
synonym: "regulation of RNA export out of nucleus" EXACT []
synonym: "regulation of RNA transport from nucleus to cytoplasm" EXACT []
synonym: "regulation of RNA-nucleus export" EXACT []
is_a: GO:0032239 ! regulation of nucleobase-containing compound transport
is_a: GO:0046822 ! regulation of nucleocytoplasmic transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006405 ! RNA export from nucleus
relationship: regulates GO:0006405 ! RNA export from nucleus

[Term]
id: GO:0046832
name: negative regulation of RNA export from nucleus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of RNA from the nucleus into the cytoplasm." [GOC:bf]
synonym: "down regulation of RNA export from nucleus" EXACT []
synonym: "down-regulation of RNA export from nucleus" EXACT []
synonym: "downregulation of RNA export from nucleus" EXACT []
synonym: "inhibition of RNA export from nucleus" NARROW []
synonym: "negative regulation of RNA export from cell nucleus" EXACT []
synonym: "negative regulation of RNA export out of nucleus" EXACT []
synonym: "negative regulation of RNA transport from nucleus to cytoplasm" EXACT []
synonym: "negative regulation of RNA-nucleus export" EXACT []
is_a: GO:0032240 ! negative regulation of nucleobase-containing compound transport
is_a: GO:0046823 ! negative regulation of nucleocytoplasmic transport
is_a: GO:0046831 ! regulation of RNA export from nucleus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006405 ! RNA export from nucleus
relationship: negatively_regulates GO:0006405 ! RNA export from nucleus

[Term]
id: GO:0046833
name: positive regulation of RNA export from nucleus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of directed movement of RNA from the nucleus into the cytoplasm." [GOC:bf]
synonym: "activation of RNA export from nucleus" NARROW []
synonym: "positive regulation of RNA export from cell nucleus" EXACT []
synonym: "positive regulation of RNA export out of nucleus" EXACT []
synonym: "positive regulation of RNA transport from nucleus to cytoplasm" EXACT []
synonym: "positive regulation of RNA-nucleus export" EXACT []
synonym: "stimulation of RNA export from nucleus" NARROW []
synonym: "up regulation of RNA export from nucleus" EXACT []
synonym: "up-regulation of RNA export from nucleus" EXACT []
synonym: "upregulation of RNA export from nucleus" EXACT []
is_a: GO:0032241 ! positive regulation of nucleobase-containing compound transport
is_a: GO:0046824 ! positive regulation of nucleocytoplasmic transport
is_a: GO:0046831 ! regulation of RNA export from nucleus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006405 ! RNA export from nucleus
relationship: positively_regulates GO:0006405 ! RNA export from nucleus

[Term]
id: GO:0046834
name: lipid phosphorylation
namespace: biological_process
def: "The process of introducing one or more phosphate groups into a lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents." [GOC:bf, ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0016310 ! phosphorylation
is_a: GO:0030258 ! lipid modification

[Term]
id: GO:0046835
name: carbohydrate phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y." [ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0016310 ! phosphorylation
is_a: GO:0044262 ! cellular carbohydrate metabolic process

[Term]
id: GO:0046836
name: glycolipid transport
namespace: biological_process
def: "The directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0006869 ! lipid transport
is_a: GO:1901264 ! carbohydrate derivative transport

[Term]
id: GO:0046838
name: phosphorylated carbohydrate dephosphorylation
namespace: biological_process
def: "The process of removing a phosphate group from a phosphorylated carbohydrate, any organic compound based on the general formula Cx(H2O)y with a phosphate group attached to it." [ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0016311 ! dephosphorylation
is_a: GO:0044262 ! cellular carbohydrate metabolic process

[Term]
id: GO:0046839
name: phospholipid dephosphorylation
namespace: biological_process
def: "The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents." [ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0016311 ! dephosphorylation
is_a: GO:0030258 ! lipid modification

[Term]
id: GO:0046841
name: trisporic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving trisporic acid, a carotenoic acid derivative used as a pheromone in some species of Zygomycota." [GOC:ai]
subset: gosubset_prok
synonym: "trisporic acid metabolism" EXACT []
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0046842
name: trisporic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of trisporic acid." [GOC:ai]
subset: gosubset_prok
synonym: "trisporic acid anabolism" EXACT []
synonym: "trisporic acid biosynthesis" EXACT []
synonym: "trisporic acid formation" EXACT []
synonym: "trisporic acid synthesis" EXACT []
is_a: GO:0046841 ! trisporic acid metabolic process

[Term]
id: GO:0046843
name: dorsal appendage formation
namespace: biological_process
def: "Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration." [ISBN:0879694238]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0007306 ! eggshell chorion assembly

[Term]
id: GO:0046844
name: micropyle formation
namespace: biological_process
def: "Establishment of the micropyle, a single cone-shaped specialization of the chorion that allows sperm entry into the egg prior to fertilization." [ISBN:0879694238]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0007306 ! eggshell chorion assembly

[Term]
id: GO:0046845
name: branched duct epithelial cell fate determination, open tracheal system
namespace: biological_process
def: "Allocation of a set number of cells to each primary branch in an open tracheal system, prior to the onset of cell migration. This establishes different domains of cells within the tracheal placode." [GOC:mtg_sensu, PMID:10684581]
synonym: "branch cell fate determination" BROAD []
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0007424 ! open tracheal system development

[Term]
id: GO:0046847
name: filopodium assembly
namespace: biological_process
def: "The assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:dph, GOC:mah, GOC:tb, PMID:16337369, PMID:18464790]
synonym: "filopodia biosynthesis" RELATED []
synonym: "filopodia formation" RELATED []
synonym: "filopodium formation" RELATED [GOC:dph, GOC:tb]
is_a: GO:0030031 ! cell projection assembly

[Term]
id: GO:0046848
name: hydroxyapatite binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with hydroxyapatite, the calcium phosphate mineral of formula Ca10(PO4)6(OH)2 found both in rocks of nonorganic origin and as a component of bone and dentin." [CHEBI:52255, GOC:curators]
synonym: "hydroxylapatite binding" EXACT [GOC:vk]
is_a: GO:0005488 ! binding

[Term]
id: GO:0046849
name: bone remodeling
namespace: biological_process
def: "The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis." [GOC:curators]
synonym: "bone remodelling" EXACT []
xref: Wikipedia:Bone_remodeling
is_a: GO:0048771 ! tissue remodeling

[Term]
id: GO:0046850
name: regulation of bone remodeling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity." [GOC:ai]
is_a: GO:0034103 ! regulation of tissue remodeling
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0046849 ! bone remodeling
relationship: regulates GO:0046849 ! bone remodeling

[Term]
id: GO:0046851
name: negative regulation of bone remodeling
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of bone remodeling." [GOC:ai]
synonym: "down regulation of bone remodeling" EXACT []
synonym: "down-regulation of bone remodeling" EXACT []
synonym: "downregulation of bone remodeling" EXACT []
synonym: "inhibition of bone remodeling" NARROW []
is_a: GO:0034104 ! negative regulation of tissue remodeling
is_a: GO:0046850 ! regulation of bone remodeling
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0046849 ! bone remodeling
relationship: negatively_regulates GO:0046849 ! bone remodeling

[Term]
id: GO:0046852
name: positive regulation of bone remodeling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of bone remodeling." [GOC:ai]
synonym: "activation of bone remodeling" NARROW []
synonym: "stimulation of bone remodeling" NARROW []
synonym: "up regulation of bone remodeling" EXACT []
synonym: "up-regulation of bone remodeling" EXACT []
synonym: "upregulation of bone remodeling" EXACT []
is_a: GO:0034105 ! positive regulation of tissue remodeling
is_a: GO:0046850 ! regulation of bone remodeling
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0046849 ! bone remodeling
relationship: positively_regulates GO:0046849 ! bone remodeling

[Term]
id: GO:0046853
name: obsolete inositol or phosphatidylinositol phosphorylation
namespace: biological_process
def: "OBSOLETE. The process of introducing a phosphate group into inositol or a phosphatidylinositol. Inositol is the cyclic alcohol 1,2,3,4,5,6-cyclohexanehexol, which is widely distributed in nature and acts as a growth factor in animals and microorganisms." [CHEBI:24848, ISBN:0198506732]
comment: This term was made obsolete because it is a grouping term representing two quite different sets of entities, hexose sugars and glycerophospholipids.
synonym: "inositol and derivative phosphorylation" RELATED [GOC:curators]
synonym: "inositol or phosphatidylinositol phosphorylation" EXACT []
synonym: "myo-inositol and derivative phosphorylation" RELATED []
synonym: "myo-inositol or phosphatidyl-myo-inositol phosphorylation" NARROW [GOC:curators]
is_obsolete: true
consider: GO:0046854
consider: GO:0052746

[Term]
id: GO:0046854
name: phosphatidylinositol phosphorylation
namespace: biological_process
alt_id: GO:0046837
def: "The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol." [ISBN:0198506732]
subset: gosubset_prok
synonym: "phosphatidylinositol phosphate biosynthetic process" NARROW []
synonym: "phosphatidylinositol phosphate phosphorylation" NARROW []
synonym: "phosphoinositide phosphorylation" NARROW []
synonym: "PIP biosynthesis" NARROW []
synonym: "PtdInsP biosynthesis" NARROW []
xref: Reactome:REACT_6223 "Phosphorylation of PIP2 to PIP3 by Dp110, Drosophila melanogaster"
is_a: GO:0046488 ! phosphatidylinositol metabolic process
is_a: GO:0046834 ! lipid phosphorylation

[Term]
id: GO:0046855
name: inositol phosphate dephosphorylation
namespace: biological_process
def: "The process of removing a phosphate group from any mono- or polyphosphorylated inositol." [ISBN:0198506732]
subset: gosubset_prok
synonym: "myo-inositol phosphate dephosphorylation" NARROW []
is_a: GO:0044723 ! single-organism carbohydrate metabolic process
is_a: GO:0046838 ! phosphorylated carbohydrate dephosphorylation
is_a: GO:0071545 ! inositol phosphate catabolic process

[Term]
id: GO:0046856
name: phosphatidylinositol dephosphorylation
namespace: biological_process
alt_id: GO:0046840
def: "The process of removing one or more phosphate groups from a phosphatidylinositol." [ISBN:0198506732]
subset: gosubset_prok
synonym: "phosphatidylinositol phosphate catabolic process" NARROW []
synonym: "phosphatidylinositol phosphate dephosphorylation" NARROW []
synonym: "phosphoinositide dephosphorylation" EXACT []
synonym: "PIP catabolism" NARROW []
synonym: "PtdInsP catabolism" NARROW []
synonym: "PtdInsP dephosphorylation" NARROW []
xref: Reactome:REACT_6317 "PIP3 dephosphorylated to PIP2 by DPTEN, Drosophila melanogaster"
is_a: GO:0046488 ! phosphatidylinositol metabolic process
is_a: GO:0046839 ! phospholipid dephosphorylation

[Term]
id: GO:0046857
name: oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]
subset: gosubset_prok
xref: EC:1.7.1
is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors

[Term]
id: GO:0046858
name: chlorosome
namespace: cellular_component
def: "A large enclosure of aggregated pigment, typically bacteriochlorophyll c (BChl c), that acts as a light-harvesting antenna structure and is characteristic of green photosynthetic bacteria (e.g. Chlorobiaceae). The BChl aggregates are organized into lamellar elements by pigment-pigment rather than pigment-protein interactions. Chlorosomes also contain BChl a, carotenoids, quinones, lipids, and proteins, and are attached to the cytoplasmic membrane via a BChl a-containing protein baseplate." [ISBN:0198506732, PMID:14729689, PMID:15298919]
subset: gosubset_prok
xref: Wikipedia:Chlorosome
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle

[Term]
id: GO:0046859
name: hydrogenosomal membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a hydrogenosome." [GOC:ai]
synonym: "hydrogenosome membrane" EXACT []
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0098588 ! bounding membrane of organelle
is_a: GO:0098805 ! whole membrane
relationship: part_of GO:0042566 ! hydrogenosome

[Term]
id: GO:0046860
name: glycosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a glycosome." [GOC:ai]
is_a: GO:0005778 ! peroxisomal membrane
relationship: part_of GO:0020015 ! glycosome

[Term]
id: GO:0046861
name: glyoxysomal membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a glyoxysome." [GOC:ai]
synonym: "glyoxysome membrane" EXACT []
is_a: GO:0005778 ! peroxisomal membrane

[Term]
id: GO:0046862
name: chromoplast membrane
namespace: cellular_component
def: "Either of the lipid bilayers that surround a chromoplast and form the chromoplast envelope." [GOC:ai, GOC:mah]
is_a: GO:0042170 ! plastid membrane
relationship: part_of GO:0031898 ! chromoplast envelope

[Term]
id: GO:0046863
name: ribulose-1,5-bisphosphate carboxylase/oxygenase activator activity
namespace: molecular_function
alt_id: GO:0018236
def: "Increases the activity of rubisco by the removal of otherwise inhibitory sugar phosphates: RuBP, and in some plants, 2-carboxyarabinitol 1-phosphate." [PMID:10430961, PMID:10965036, PMID:2404515]
comment: See also the molecular function term 'ribulose-bisphosphate carboxylase activity ; GO:0016984'.
synonym: "ribulose-1,5-bisphosphate carboxylase/oxygenase activase activity" EXACT [GOC:dph, GOC:tb]
synonym: "ribulose-bisphosphate carboxylase activase activity" EXACT []
synonym: "rubisco activase activity" EXACT []
synonym: "rubisco activator" EXACT []
is_a: GO:0008047 ! enzyme activator activity
relationship: positively_regulates GO:0016984 ! ribulose-bisphosphate carboxylase activity

[Term]
id: GO:0046864
name: isoprenoid transport
namespace: biological_process
def: "The directed movement of isoprenoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Isoprenoids comprise a group of compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [GOC:ai]
subset: goslim_pir
is_a: GO:0006869 ! lipid transport

[Term]
id: GO:0046865
name: terpenoid transport
namespace: biological_process
def: "The directed movement of terpenoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Terpenoids are a class of compounds characterized by an isoprenoid chemical structure and include derivatives with various functional groups." [GOC:ai]
is_a: GO:0046864 ! isoprenoid transport

[Term]
id: GO:0046866
name: tetraterpenoid transport
namespace: biological_process
def: "The directed movement of tetraterpenoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Tetraterpenoids are terpenoids with eight isoprene units." [GOC:ai]
is_a: GO:0046865 ! terpenoid transport

[Term]
id: GO:0046867
name: carotenoid transport
namespace: biological_process
def: "The directed movement of carotenoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carotenoids are tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [GOC:ai]
is_a: GO:0046866 ! tetraterpenoid transport

[Term]
id: GO:0046868
name: mesosome
namespace: cellular_component
def: "An intracellular, often complex, membranous structure, sometimes with additional membranous lamellae inside, found in bacteria. They are associated with synthesis of DNA and secretion of proteins." [ISBN:0198506732, ISBN:0716731363]
subset: gosubset_prok
xref: Wikipedia:Mesosome
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0046869
name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-aspartato diiron disulfide
namespace: biological_process
def: "The incorporation of iron into a 2Fe-2S iron-sulfur cluster via tris-L-cysteinyl-L-aspartato diiron disulfide." [RESID:AA0331]
subset: gosubset_prok
synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-aspartato diiron disulphide" EXACT []
xref: RESID:AA0331
is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster

[Term]
id: GO:0046870
name: cadmium ion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with cadmium (Cd) ions." [GOC:ai]
subset: gosubset_prok
synonym: "cadmium binding" EXACT []
synonym: "copper/cadmium binding" BROAD []
is_a: GO:0046914 ! transition metal ion binding

[Term]
id: GO:0046871
name: N-acetylgalactosamine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with N-acetylgalactosamine, 2-acetamido-2-deoxygalactopyranose, the n-acetyl derivative of galactosamine." [CHEBI:28800, GOC:ai]
synonym: "N-acetylgalactosamine lectin" RELATED []
is_a: GO:0097367 ! carbohydrate derivative binding

[Term]
id: GO:0046872
name: metal ion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any metal ion." [GOC:ai]
subset: goslim_metagenomics
subset: gosubset_prok
synonym: "heavy metal binding" NARROW []
synonym: "metal binding" EXACT []
is_a: GO:0043169 ! cation binding

[Term]
id: GO:0046873
name: metal ion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of metal ions from one side of a membrane to the other." [GOC:ai]
subset: gosubset_prok
synonym: "heavy metal ion porter activity" NARROW []
synonym: "heavy metal ion transporter activity" NARROW []
synonym: "heavy metal ion:hydrogen symporter activity" NARROW []
synonym: "heavy metal-exporting ATPase activity" NARROW []
synonym: "high affinity metal ion uptake transporter activity" NARROW []
synonym: "low affinity metal ion uptake transporter activity" NARROW []
is_a: GO:0022890 ! inorganic cation transmembrane transporter activity
relationship: part_of GO:0030001 ! metal ion transport

[Term]
id: GO:0046874
name: quinolinate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid." [GOC:ai]
subset: gosubset_prok
synonym: "quinolinate metabolism" EXACT []
is_a: GO:0043648 ! dicarboxylic acid metabolic process
is_a: GO:0072524 ! pyridine-containing compound metabolic process

[Term]
id: GO:0046875
name: ephrin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an ephrin receptor." [GOC:ai]
synonym: "Eph receptor binding" EXACT []
synonym: "ephrin" NARROW []
synonym: "GPI-linked ephrin" NARROW []
synonym: "transmembrane ephrin" NARROW []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0046876
name: 3,4-didehydroretinal binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with 3,4-didehydroretinal, a form of retinal that plays a role in the visual process in freshwater fish and some amphibians analogous to that of all-trans retinal in other vertebrates. 3,4-didehydro-11-cis-retinal combines with an opsin to form cyanopsin (cone) or porphyropsin (rod)." [GOC:ai, ISBN:0198506732]
synonym: "blue-sensitive opsin" NARROW []
synonym: "green-sensitive opsin" NARROW []
synonym: "long-wave-sensitive opsin" NARROW []
synonym: "opsin" NARROW []
synonym: "red-sensitive opsin" NARROW []
synonym: "short-wave-sensitive opsin" NARROW []
synonym: "UV-sensitive opsin" NARROW []
synonym: "violet-sensitive opsin" NARROW []
is_a: GO:0005501 ! retinoid binding

[Term]
id: GO:0046877
name: regulation of saliva secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of saliva from a cell or a tissue." [GOC:ai]
is_a: GO:0044058 ! regulation of digestive system process
is_a: GO:0050878 ! regulation of body fluid levels
is_a: GO:0051046 ! regulation of secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0046541 ! saliva secretion
relationship: regulates GO:0046541 ! saliva secretion

[Term]
id: GO:0046878
name: positive regulation of saliva secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of saliva." [GOC:ai]
synonym: "activation of saliva secretion" NARROW []
synonym: "stimulation of saliva secretion" NARROW []
synonym: "up regulation of saliva secretion" EXACT []
synonym: "up-regulation of saliva secretion" EXACT []
synonym: "upregulation of saliva secretion" EXACT []
is_a: GO:0046877 ! regulation of saliva secretion
is_a: GO:0051047 ! positive regulation of secretion
is_a: GO:0060456 ! positive regulation of digestive system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0046541 ! saliva secretion
relationship: positively_regulates GO:0046541 ! saliva secretion

[Term]
id: GO:0046879
name: hormone secretion
namespace: biological_process
def: "The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells." [ISBN:0198506732]
is_a: GO:0009914 ! hormone transport
is_a: GO:0023061 ! signal release

[Term]
id: GO:0046880
name: regulation of follicle-stimulating hormone secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of follicle-stimulating hormone." [GOC:ai]
synonym: "regulation of follicle stimulating hormone secretion" EXACT []
synonym: "regulation of FSH secretion" EXACT []
is_a: GO:0032276 ! regulation of gonadotropin secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0046884 ! follicle-stimulating hormone secretion
relationship: regulates GO:0046884 ! follicle-stimulating hormone secretion

[Term]
id: GO:0046881
name: positive regulation of follicle-stimulating hormone secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of follicle-stimulating hormone." [GOC:ai]
synonym: "activation of follicle-stimulating hormone secretion" NARROW []
synonym: "positive regulation of follicle stimulating hormone secretion" EXACT []
synonym: "stimulation of follicle-stimulating hormone secretion" NARROW []
synonym: "up regulation of follicle-stimulating hormone secretion" EXACT []
synonym: "up-regulation of follicle-stimulating hormone secretion" EXACT []
synonym: "upregulation of follicle-stimulating hormone secretion" EXACT []
is_a: GO:0032278 ! positive regulation of gonadotropin secretion
is_a: GO:0046880 ! regulation of follicle-stimulating hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0046884 ! follicle-stimulating hormone secretion
relationship: positively_regulates GO:0046884 ! follicle-stimulating hormone secretion

[Term]
id: GO:0046882
name: negative regulation of follicle-stimulating hormone secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of follicle-stimulating hormone." [GOC:ai]
synonym: "down regulation of follicle-stimulating hormone secretion" EXACT []
synonym: "down-regulation of follicle-stimulating hormone secretion" EXACT []
synonym: "downregulation of follicle-stimulating hormone secretion" EXACT []
synonym: "inhibition of follicle-stimulating hormone secretion" NARROW []
synonym: "negative regulation of follicle stimulating hormone secretion" EXACT []
is_a: GO:0032277 ! negative regulation of gonadotropin secretion
is_a: GO:0046880 ! regulation of follicle-stimulating hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0046884 ! follicle-stimulating hormone secretion
relationship: negatively_regulates GO:0046884 ! follicle-stimulating hormone secretion

[Term]
id: GO:0046883
name: regulation of hormone secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell." [GOC:ai]
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0010817 ! regulation of hormone levels
is_a: GO:0023051 ! regulation of signaling
is_a: GO:1903530 ! regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0046879 ! hormone secretion
relationship: regulates GO:0046879 ! hormone secretion

[Term]
id: GO:0046884
name: follicle-stimulating hormone secretion
namespace: biological_process
def: "The regulated release of follicle-stimulating hormone, a gonadotropic glycoprotein hormone secreted by the anterior pituitary." [ISBN:0198506732]
synonym: "follicle stimulating hormone secretion" EXACT []
synonym: "follitropin secretion" EXACT []
synonym: "FSH secretion" EXACT []
is_a: GO:0032274 ! gonadotropin secretion

[Term]
id: GO:0046885
name: regulation of hormone biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones." [GOC:ai]
synonym: "regulation of hormone anabolism" EXACT []
synonym: "regulation of hormone biosynthesis" EXACT []
synonym: "regulation of hormone formation" EXACT []
synonym: "regulation of hormone synthesis" EXACT []
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0032350 ! regulation of hormone metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042446 ! hormone biosynthetic process
relationship: regulates GO:0042446 ! hormone biosynthetic process

[Term]
id: GO:0046886
name: positive regulation of hormone biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones." [GOC:ai]
synonym: "activation of hormone biosynthetic process" NARROW []
synonym: "positive regulation of hormone anabolism" EXACT []
synonym: "positive regulation of hormone biosynthesis" EXACT []
synonym: "positive regulation of hormone formation" EXACT []
synonym: "positive regulation of hormone synthesis" EXACT []
synonym: "stimulation of hormone biosynthetic process" NARROW []
synonym: "up regulation of hormone biosynthetic process" EXACT []
synonym: "up-regulation of hormone biosynthetic process" EXACT []
synonym: "upregulation of hormone biosynthetic process" EXACT []
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0032352 ! positive regulation of hormone metabolic process
is_a: GO:0046885 ! regulation of hormone biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042446 ! hormone biosynthetic process
relationship: positively_regulates GO:0042446 ! hormone biosynthetic process

[Term]
id: GO:0046887
name: positive regulation of hormone secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell." [GOC:ai]
synonym: "activation of hormone secretion" NARROW []
synonym: "stimulation of hormone secretion" NARROW []
synonym: "up regulation of hormone secretion" EXACT []
synonym: "up-regulation of hormone secretion" EXACT []
synonym: "upregulation of hormone secretion" EXACT []
is_a: GO:0010647 ! positive regulation of cell communication
is_a: GO:0023056 ! positive regulation of signaling
is_a: GO:0046883 ! regulation of hormone secretion
is_a: GO:1903532 ! positive regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0046879 ! hormone secretion
relationship: positively_regulates GO:0046879 ! hormone secretion

[Term]
id: GO:0046888
name: negative regulation of hormone secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell." [GOC:ai]
synonym: "down regulation of hormone secretion" EXACT []
synonym: "down-regulation of hormone secretion" EXACT []
synonym: "downregulation of hormone secretion" EXACT []
synonym: "inhibition of hormone secretion" NARROW []
is_a: GO:0010648 ! negative regulation of cell communication
is_a: GO:0023057 ! negative regulation of signaling
is_a: GO:0046883 ! regulation of hormone secretion
is_a: GO:1903531 ! negative regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0046879 ! hormone secretion
relationship: negatively_regulates GO:0046879 ! hormone secretion

[Term]
id: GO:0046889
name: positive regulation of lipid biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai]
subset: gosubset_prok
synonym: "activation of lipid biosynthetic process" NARROW []
synonym: "positive regulation of lipid anabolism" EXACT []
synonym: "positive regulation of lipid biosynthesis" EXACT []
synonym: "positive regulation of lipid formation" EXACT []
synonym: "positive regulation of lipid synthesis" EXACT []
synonym: "positive regulation of lipogenesis" EXACT [GOC:sl]
synonym: "stimulation of lipid biosynthetic process" NARROW []
synonym: "up regulation of lipid biosynthetic process" EXACT []
synonym: "up-regulation of lipid biosynthetic process" EXACT []
synonym: "upregulation of lipid biosynthetic process" EXACT []
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:0045834 ! positive regulation of lipid metabolic process
is_a: GO:0046890 ! regulation of lipid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008610 ! lipid biosynthetic process
relationship: positively_regulates GO:0008610 ! lipid biosynthetic process

[Term]
id: GO:0046890
name: regulation of lipid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai]
subset: gosubset_prok
synonym: "regulation of lipid anabolism" EXACT []
synonym: "regulation of lipid biosynthesis" EXACT []
synonym: "regulation of lipid formation" EXACT []
synonym: "regulation of lipid synthesis" EXACT []
synonym: "regulation of lipogenesis" EXACT [GOC:sl]
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0019216 ! regulation of lipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008610 ! lipid biosynthetic process
relationship: regulates GO:0008610 ! lipid biosynthetic process

[Term]
id: GO:0046891
name: peptidyl-cysteine S-carbamoylation
namespace: biological_process
def: "The carbamoylation of peptidyl-cysteine to form peptidyl-S-carbamoyl-L-cysteine." [RESID:AA0332]
subset: gosubset_prok
xref: RESID:AA0332
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0046892
name: peptidyl-S-carbamoyl-L-cysteine dehydration
namespace: biological_process
def: "The dehydration of peptidyl-S-carbamoyl-L-cysteine to form peptidyl-S-cyano-L-cysteine." [PMID:12586941, RESID:AA0333]
subset: gosubset_prok
synonym: "formation of peptidyl-S-cyanocysteine" EXACT []
synonym: "formation of peptidyl-serine thiocyanate ester" EXACT []
xref: RESID:AA0333
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018249 ! protein dehydration

[Term]
id: GO:0046893
name: iron incorporation into hydrogenase diiron subcluster via L-cysteine ligation
namespace: biological_process
def: "The incorporation of iron into an L-cysteinyl diiron subcluster, found in Fe-hydrogenase." [RESID:AA0334]
subset: gosubset_prok
xref: RESID:AA0334
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0046894
name: enzyme active site formation via S-amidino-L-cysteine
namespace: biological_process
def: "Active site formation via the transient amidinylation of peptidyl-cysteine to form peptidyl-S-amidino-L-cysteine." [RESID:AA0335]
subset: gosubset_prok
is_a: GO:0018307 ! enzyme active site formation
is_a: GO:0098823 ! peptidyl-cysteine modification to S-amindino-L-cysteine

[Term]
id: GO:0046895
name: N-terminal peptidyl-isoleucine methylation
namespace: biological_process
def: "The methylation of the N-terminal isoleucine of proteins to form the derivative N-methyl-L-isoleucine." [RESID:AA0336]
subset: gosubset_prok
xref: RESID:AA0336
is_a: GO:0006480 ! N-terminal protein amino acid methylation
is_a: GO:0018203 ! peptidyl-isoleucine modification

[Term]
id: GO:0046896
name: N-terminal peptidyl-leucine methylation
namespace: biological_process
def: "The methylation of the N-terminal leucine of proteins to form the derivative N-methyl-L-leucine." [RESID:AA0337]
subset: gosubset_prok
xref: RESID:AA0337
is_a: GO:0006480 ! N-terminal protein amino acid methylation
is_a: GO:0018204 ! peptidyl-leucine modification

[Term]
id: GO:0046897
name: N-terminal peptidyl-tyrosine methylation
namespace: biological_process
def: "The methylation of the N-terminal tyrosine of proteins to form the derivative N-methyl-L-tyrosine." [RESID:AA0338]
subset: gosubset_prok
xref: RESID:AA0338
is_a: GO:0006480 ! N-terminal protein amino acid methylation
is_a: GO:0018212 ! peptidyl-tyrosine modification

[Term]
id: GO:0046898
name: response to cycloheximide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cycloheximide stimulus. Cycloheximide (actidione) is an antibiotic produced by some Streptomyces species which interferes with protein synthesis in eukaryotes." [CHEBI:27641, GOC:ef, ISBN:0198506732]
synonym: "response to actidione" EXACT []
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0097305 ! response to alcohol
is_a: GO:1901654 ! response to ketone

[Term]
id: GO:0046899
name: nucleoside triphosphate adenylate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside triphosphate + AMP = nucleoside diphosphate + ADP." [EC:2.7.4.10]
synonym: "GTP:AMP phosphotransferase" NARROW []
synonym: "guanosine triphosphate-adenylate kinase" NARROW []
synonym: "isozyme 3 of adenylate kinase activity" EXACT [EC:2.7.4.10]
synonym: "nucleoside triphosphate-adenosine monophosphate transphosphorylase activity" EXACT []
synonym: "nucleoside-triphosphate-adenylate kinase activity" EXACT []
synonym: "nucleoside-triphosphate:AMP phosphotransferase activity" EXACT [EC:2.7.4.10]
xref: EC:2.7.4.10
xref: MetaCyc:2.7.4.10-RXN
xref: Reactome:REACT_25345 "Adenylate Kinase 3 is a GTP-AMP phosphotransferase, Homo sapiens"
xref: RHEA:13752
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor
is_a: GO:0019205 ! nucleobase-containing compound kinase activity

[Term]
id: GO:0046900
name: tetrahydrofolylpolyglutamate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tetrahydrofolylpolyglutamate, a folate derivative comprising tetrahydrofolate attached to a chain of glutamate residues." [GOC:ai]
subset: gosubset_prok
synonym: "tetrahydrofolyl-[Glu](n) metabolic process" EXACT []
synonym: "tetrahydrofolyl-[Glu](n) metabolism" EXACT []
synonym: "tetrahydrofolylpolyglutamate metabolism" EXACT []
is_a: GO:0006760 ! folic acid-containing compound metabolic process

[Term]
id: GO:0046901
name: tetrahydrofolylpolyglutamate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tetrahydrofolylpolyglutamate, a folate derivative comprising tetrahydrofolate attached to a chain of glutamate residues." [GOC:ai]
subset: gosubset_prok
synonym: "folic acid-containing compound polyglutamylation" BROAD [GOC:dhl]
synonym: "tetrahydrofolate polyglutamylation" EXACT [GOC:bf, KEGG:ec00790]
synonym: "tetrahydrofolyl-[Glu](n) biosynthesis" EXACT []
synonym: "tetrahydrofolyl-[Glu](n) biosynthetic process" EXACT []
synonym: "tetrahydrofolylpolyglutamate anabolism" EXACT []
synonym: "tetrahydrofolylpolyglutamate biosynthesis" EXACT []
synonym: "tetrahydrofolylpolyglutamate formation" EXACT []
synonym: "tetrahydrofolylpolyglutamate synthesis" EXACT []
synonym: "THF polyglutamylation" EXACT [GOC:bf, KEGG:ec00790]
is_a: GO:0009396 ! folic acid-containing compound biosynthetic process
is_a: GO:0046900 ! tetrahydrofolylpolyglutamate metabolic process

[Term]
id: GO:0046902
name: regulation of mitochondrial membrane permeability
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane." [GOC:bf]
synonym: "regulation of mitochondrial envelope permeability" RELATED []
synonym: "regulation of transport across mitochondrial membrane" EXACT []
is_a: GO:0007006 ! mitochondrial membrane organization
is_a: GO:0090559 ! regulation of membrane permeability
relationship: part_of GO:0006839 ! mitochondrial transport

[Term]
id: GO:0046903
name: secretion
namespace: biological_process
def: "The controlled release of a substance by a cell or a tissue." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0044765 ! single-organism transport

[Term]
id: GO:0046904
name: calcium oxalate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with calcium oxalate, CaC2O4, a salt of oxalic acid. In animals, it may be excreted in urine or retained in the form of urinary calculi." [ISBN:0721662544]
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0046905
name: phytoene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: prephytoene pyrophosphate = phytoene + diphosphate." [GOC:ai, PMID:12641468]
comment: Note that this should not be confused with 'geranylgeranyl-diphosphate geranylgeranyltransferase activity ; GO:0016767', EC:2.5.1.32. This activity is the second part of the formation of phytoene from geranylgeranyl-diphosphate, the first stage of which is catalyzed by EC:2.5.1.32.
is_a: GO:0003824 ! catalytic activity
relationship: part_of GO:0016120 ! carotene biosynthetic process

[Term]
id: GO:0046906
name: tetrapyrrole binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a tetrapyrrole, a compound containing four pyrrole nuclei variously substituted and linked to each other through carbons at the alpha position." [CHEBI:26932, GOC:curators, ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
synonym: "porphyrin binding" NARROW []
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding

[Term]
id: GO:0046907
name: intracellular transport
namespace: biological_process
def: "The directed movement of substances within a cell." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006810 ! transport
is_a: GO:0051649 ! establishment of localization in cell
intersection_of: GO:0006810 ! transport
intersection_of: occurs_in GO:0005622 ! intracellular
relationship: occurs_in GO:0005622 ! intracellular

[Term]
id: GO:0046908
name: obsolete negative regulation of crystal formation
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the spontaneous (nonenzymatic) formation of crystals in a solution, for example, calcium oxalate crystals in urine." [GOC:ai]
comment: This term was made obsolete because a more appropriate term was created.
synonym: "negative regulation of crystal formation" EXACT []
synonym: "negative regulation of mineralization" RELATED []
is_obsolete: true
replaced_by: GO:0050801

[Term]
id: GO:0046909
name: intermembrane transport
namespace: biological_process
def: "The directed movement of substances between any membrane of a cell, including the plasma membrane and its regions." [GOC:ai, GOC:pr, PMID:10671554]
comment: Examples of intermembrane transport are the transfer of glycolipids from the endoplasmic reticulum to other cellular membrane structures in which they reside, and the movement of proteins between regions of the plasma membrane (where one region could be the ciliary membrane).
is_a: GO:0044765 ! single-organism transport

[Term]
id: GO:0046910
name: pectinesterase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of any pectinesterase enzyme." [GOC:ai, PMID:10880981]
comment: See also the molecular function term 'pectinesterase activity ; GO:0030599'.
is_a: GO:0004857 ! enzyme inhibitor activity
relationship: negatively_regulates GO:0030599 ! pectinesterase activity

[Term]
id: GO:0046911
name: metal chelating activity
namespace: molecular_function
def: "The formation of bonds from two or more atoms within the same ligand to a metal atom in complexes in which the metal is part of a ring." [ISBN:0198506732, ISBN:0716731363]
subset: gosubset_prok
synonym: "heavy metal chelation" NARROW []
synonym: "metal chelation" EXACT []
is_a: GO:0046872 ! metal ion binding

[Term]
id: GO:0046912
name: transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer
namespace: molecular_function
def: "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer." [GOC:jl]
subset: gosubset_prok
xref: EC:2.3.3
is_a: GO:0016746 ! transferase activity, transferring acyl groups

[Term]
id: GO:0046914
name: transition metal ion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0046872 ! metal ion binding

[Term]
id: GO:0046915
name: transition metal ion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of transition metal ions from one side of a membrane to the other. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0046873 ! metal ion transmembrane transporter activity
relationship: part_of GO:0000041 ! transition metal ion transport

[Term]
id: GO:0046916
name: cellular transition metal ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of transition metal ions at the level of a cell. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [GOC:mah, ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0006875 ! cellular metal ion homeostasis
is_a: GO:0055076 ! transition metal ion homeostasis

[Term]
id: GO:0046917
name: triphosphoribosyl-dephospho-CoA synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 3-dephospho-CoA = 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA + adenine." [EC:2.7.8.25]
subset: gosubset_prok
synonym: "2'-(5''-triphosphoribosyl)-3-dephospho-CoA synthase activity" EXACT [EC:2.7.8.25]
synonym: "ATP:3-dephospho-CoA 5''-triphosphoribosyltransferase activity" EXACT [EC:2.7.8.25]
synonym: "ATP:dephospho-CoA 5-triphosphoribosyl transferase activity" EXACT []
synonym: "CitG activity" RELATED [EC:2.7.8.25]
xref: EC:2.7.8.25
xref: MetaCyc:2.7.8.25-RXN
xref: RHEA:15120
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0046918
name: N-terminal peptidyl-glycine N-palmitoylation
namespace: biological_process
def: "The covalent attachment of a palmitoyl group to a nitrogen (N) atom in an N-terminal glycine residue to form N-palmitoyl-glycine." [RESID:AA0339]
comment: Palmitoylation of glycine only occurs when glycine is at the N-terminal position of a protein.
subset: gosubset_prok
xref: RESID:AA0339
is_a: GO:0006500 ! N-terminal protein palmitoylation

[Term]
id: GO:0046919
name: pyruvyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a pyruvyl (oxopropanoyl) group from one compound to another." [GOC:ai]
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0046920
name: alpha-(1->3)-fucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->6) linkage." [GOC:ai]
synonym: "alpha(1,3)-fucosyltransferase activity" EXACT []
synonym: "alpha-(1,3)-fucosyltransferase activity" EXACT []
synonym: "alpha-1,3-fucosyltransferase activity" EXACT []
xref: EC:2.4.1.-
is_a: GO:0008417 ! fucosyltransferase activity

[Term]
id: GO:0046921
name: alpha-(1->6)-fucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->6) linkage." [GOC:ai]
synonym: "alpha(1,6)-fucosyltransferase activity" EXACT []
synonym: "alpha-(1,6)-fucosyltransferase activity" EXACT []
synonym: "alpha-1,6-fucosyltransferase activity" EXACT []
xref: EC:2.4.1.-
is_a: GO:0008417 ! fucosyltransferase activity

[Term]
id: GO:0046922
name: peptide-O-fucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an alpha-L-fucosyl residue from GDP- beta-L-fucose to the serine hydroxy group of a protein acceptor." [EC:2.4.1.221]
synonym: "GDP-beta-L-fucose:polypeptide O-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.221]
synonym: "GDP-fucose protein O-fucosyltransferase activity" EXACT [EC:2.4.1.221]
synonym: "GDP-fucose:polypeptide fucosyltransferase activity" EXACT [EC:2.4.1.221]
synonym: "GDP-L-fucose:polypeptide fucosyltransferase activity" EXACT [EC:2.4.1.221]
xref: EC:2.4.1.221
xref: MetaCyc:2.4.1.221-RXN
is_a: GO:0008417 ! fucosyltransferase activity
relationship: part_of GO:0036066 ! protein O-linked fucosylation

[Term]
id: GO:0046923
name: ER retention sequence binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an endoplasmic reticulum (ER) retention sequence, a specific peptide sequence that ensures a protein is retained within the ER." [GOC:ai]
synonym: "endoplasmic reticulum retention sequence binding" EXACT []
is_a: GO:0005048 ! signal sequence binding

[Term]
id: GO:0046924
name: peptide cross-linking via 2-(S-L-cysteinyl)-L-phenylalanine
namespace: biological_process
def: "The cross-linking of a cysteine residue to an L-phenylalanine residue to form 2-(S-L-cysteinyl)-L-phenylalanine." [PMID:12696888, RESID:AA0340]
subset: gosubset_prok
xref: RESID:AA0340
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018207 ! peptidyl-phenylalanine modification

[Term]
id: GO:0046925
name: peptide cross-linking via 2-(S-L-cysteinyl)-D-phenylalanine
namespace: biological_process
def: "The cross-linking of a cysteine residue to an L-phenylalanine residue to form 2-(S-L-cysteinyl)-D-phenylalanine." [PMID:12696888, RESID:AA0341]
subset: gosubset_prok
xref: RESID:AA0341
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018207 ! peptidyl-phenylalanine modification

[Term]
id: GO:0046926
name: peptide cross-linking via 2-(S-L-cysteinyl)-D-allo-threonine
namespace: biological_process
def: "The post-translational cross-linking of a cysteine residue to an L-threonine residue to form 2-(S-L-cysteinyl)-D-allo-threonine." [PMID:12696888, RESID:AA0342]
subset: gosubset_prok
xref: RESID:AA0342
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018210 ! peptidyl-threonine modification

[Term]
id: GO:0046927
name: peptidyl-threonine racemization
namespace: biological_process
def: "The racemization of peptidyl-L-threo-threonine at the alpha-carbon to form D-allo-threonine. This is coupled with the formation of the cross-link 2-(S-L-cysteinyl)-D-allo-threonine." [PMID:12696888]
subset: gosubset_prok
is_a: GO:0018085 ! peptidyl-L-amino acid racemization
is_a: GO:0018210 ! peptidyl-threonine modification

[Term]
id: GO:0046928
name: regulation of neurotransmitter secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell." [GOC:ai]
is_a: GO:0001505 ! regulation of neurotransmitter levels
is_a: GO:0050804 ! modulation of synaptic transmission
is_a: GO:0051588 ! regulation of neurotransmitter transport
is_a: GO:1903530 ! regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007269 ! neurotransmitter secretion
relationship: regulates GO:0007269 ! neurotransmitter secretion

[Term]
id: GO:0046929
name: negative regulation of neurotransmitter secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a neurotransmitter." [GOC:ai]
synonym: "conotoxin activity" NARROW []
synonym: "down regulation of neurotransmitter secretion" EXACT []
synonym: "down-regulation of neurotransmitter secretion" EXACT []
synonym: "downregulation of neurotransmitter secretion" EXACT []
synonym: "inhibition of neurotransmitter secretion" NARROW []
is_a: GO:0046928 ! regulation of neurotransmitter secretion
is_a: GO:0050805 ! negative regulation of synaptic transmission
is_a: GO:0051589 ! negative regulation of neurotransmitter transport
is_a: GO:1903531 ! negative regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007269 ! neurotransmitter secretion
relationship: negatively_regulates GO:0007269 ! neurotransmitter secretion

[Term]
id: GO:0046930
name: pore complex
namespace: cellular_component
def: "Any small opening in a membrane that allows the passage of gases and/or liquids." [ISBN:0198506732]
subset: gosubset_prok
synonym: "channel-forming toxin activity" RELATED []
synonym: "pore" EXACT []
synonym: "pore-forming toxin activity" RELATED []
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0016021 ! integral component of membrane

[Term]
id: GO:0046931
name: pore complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a pore complex. A pore complex is a small opening in a membrane that allows the passage of liquids and/or gases." [GOC:jl, GOC:mah]
comment: See also the cellular component term 'pore complex ; GO:0046930'.
subset: gosubset_prok
synonym: "pore biosynthesis" EXACT []
synonym: "pore complex biogenesis" RELATED [GOC:mah]
synonym: "pore formation" EXACT []
synonym: "pore-forming toxin activity" RELATED []
is_a: GO:0006461 ! protein complex assembly

[Term]
id: GO:0046932
name: sodium-transporting ATP synthase activity, rotational mechanism
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate + Na+(out) = ATP + H2O + Na+(in), by a rotational mechanism." [EC:3.6.3.15, TC:3.A.2.1.2]
synonym: "sodium-translocating F-type ATPase activity" EXACT []
synonym: "sodium-transporting two-sector ATPase activity" EXACT []
xref: MetaCyc:3.6.3.15-RXN
is_a: GO:0015081 ! sodium ion transmembrane transporter activity
is_a: GO:0019829 ! cation-transporting ATPase activity
is_a: GO:0044769 ! ATPase activity, coupled to transmembrane movement of ions, rotational mechanism

[Term]
id: GO:0046933
name: proton-transporting ATP synthase activity, rotational mechanism
namespace: molecular_function
def: "Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ADP + H2O + phosphate + H+(in) = ATP + H+(out), by a rotational mechanism." [EC:3.6.3.14, TC:3.A.2.1.1]
subset: gosubset_prok
synonym: "H+-transporting ATP synthase activity" EXACT [EC:3.6.3.14]
synonym: "hydrogen ion translocating F-type ATPase activity" EXACT []
synonym: "hydrogen ion transporting ATP synthase activity, rotational mechanism" EXACT []
synonym: "hydrogen ion transporting two-sector ATPase activity" EXACT []
xref: MetaCyc:ATPSYN-RXN
xref: Reactome:REACT_104315 "ATP is synthesized from ADP and Pi by ATPase, Bos taurus"
xref: Reactome:REACT_105384 "ATP is synthesized from ADP and Pi by ATPase, Rattus norvegicus"
xref: Reactome:REACT_106830 "ATP is synthesized from ADP and Pi by ATPase, Canis familiaris"
xref: Reactome:REACT_190 "ATP is synthesized from ADP and Pi by ATPase, Homo sapiens"
xref: Reactome:REACT_33014 "ATP is synthesized from ADP and Pi by ATPase, Danio rerio"
xref: Reactome:REACT_86305 "ATP is synthesized from ADP and Pi by ATPase, Gallus gallus"
xref: Reactome:REACT_92655 "ATP is synthesized from ADP and Pi by ATPase, Mus musculus"
xref: Reactome:REACT_96844 "ATP is synthesized from ADP and Pi by ATPase, Sus scrofa"
is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity
is_a: GO:0019829 ! cation-transporting ATPase activity
is_a: GO:0044769 ! ATPase activity, coupled to transmembrane movement of ions, rotational mechanism

[Term]
id: GO:0046934
name: phosphatidylinositol-4,5-bisphosphate 3-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H(+)." [EC:2.7.1.153, RHEA:21295]
synonym: "ATP:1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 3-phosphotransferase activity" EXACT [EC:2.7.1.153]
synonym: "phosphatidylinositol 3-kinase activity, class I" NARROW []
synonym: "phosphatidylinositol 3-kinase activity, class II" NARROW []
synonym: "phosphatidylinositol 3-kinase, class I, catalyst activity" NARROW []
synonym: "type I phosphoinositide 3-kinase activity" NARROW [EC:2.7.1.153]
xref: EC:2.7.1.153
xref: KEGG:R04545
xref: MetaCyc:2.7.1.153-RXN
xref: Reactome:REACT_100772 "PIK3 converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3), Xenopus tropicalis"
xref: Reactome:REACT_100872 "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3, Taeniopygia guttata"
xref: Reactome:REACT_101016 "CD28 bound PI3K phosphorylates PIP2 to PIP3, Rattus norvegicus"
xref: Reactome:REACT_101575 "PI3K catalyses the phosphorylation of PIP2 to PIP3, Xenopus tropicalis"
xref: Reactome:REACT_102184 "PI3K produces PIP3 and other phosphatidyl inositides, Danio rerio"
xref: Reactome:REACT_102251 "CD28 bound PI3K phosphorylates PIP2 to PIP3, Canis familiaris"
xref: Reactome:REACT_102826 "PI3K alpha, beta, gamma convert PIP2 to PIP3, Xenopus tropicalis"
xref: Reactome:REACT_102896 "PI3K phosphorylates PIP2 to PIP3, Taeniopygia guttata"
xref: Reactome:REACT_103660 "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3, Rattus norvegicus"
xref: Reactome:REACT_104423 "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3, Canis familiaris"
xref: Reactome:REACT_104428 "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3, Mus musculus"
xref: Reactome:REACT_104440 "CD28 bound PI3K phosphorylates PIP2 to PIP3, Sus scrofa"
xref: Reactome:REACT_105498 "PI3K catalyses the phosphorylation of PIP2 to PIP3, Mus musculus"
xref: Reactome:REACT_106690 "PI3K catalyses the phosphorylation of PIP2 to PIP3, Taeniopygia guttata"
xref: Reactome:REACT_106935 "PI3K produces PIP3 and other phosphatidyl inositides, Mus musculus"
xref: Reactome:REACT_108698 "PI3K catalyses the phosphorylation of PIP2 to PIP3, Danio rerio"
xref: Reactome:REACT_109561 "PI3K produces PIP3 and other phosphatidyl inositides, Xenopus tropicalis"
xref: Reactome:REACT_109902 "PI3K alpha, beta, gamma convert PIP2 to PIP3, Sus scrofa"
xref: Reactome:REACT_110442 "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3, Gallus gallus"
xref: Reactome:REACT_110694 "PIK3 converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3), Taeniopygia guttata"
xref: Reactome:REACT_115133 "PI3K phosphorylates PIP2 to PIP3, Xenopus tropicalis"
xref: Reactome:REACT_115884 "Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFR mutants, Homo sapiens"
xref: Reactome:REACT_12561 "PI3K phosphorylates PIP2 to PIP3, Homo sapiens"
xref: Reactome:REACT_12624 "PI3K produces PIP3 and other phosphatidyl inositides, Homo sapiens"
xref: Reactome:REACT_12636 "PIK3 converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3), Homo sapiens"
xref: Reactome:REACT_16877 "PI3K catalyses the phosphorylation of PIP2 to PIP3, Homo sapiens"
xref: Reactome:REACT_19274 "CD28 bound PI3K phosphorylates PIP2 to PIP3, Homo sapiens"
xref: Reactome:REACT_19310 "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3, Homo sapiens"
xref: Reactome:REACT_20608 "PI3K alpha, beta, gamma convert PIP2 to PIP3, Homo sapiens"
xref: Reactome:REACT_28751 "PI3K produces PIP3 and other phosphatidyl inositides, Drosophila melanogaster"
xref: Reactome:REACT_29081 "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3, Danio rerio"
xref: Reactome:REACT_29317 "PI3K alpha, beta, gamma convert PIP2 to PIP3, Mus musculus"
xref: Reactome:REACT_29324 "CD28 bound PI3K phosphorylates PIP2 to PIP3, Taeniopygia guttata"
xref: Reactome:REACT_32230 "PI3K alpha, beta, gamma convert PIP2 to PIP3, Rattus norvegicus"
xref: Reactome:REACT_32593 "PIK3 converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3), Rattus norvegicus"
xref: Reactome:REACT_33239 "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3, Sus scrofa"
xref: Reactome:REACT_33619 "CD28 bound PI3K phosphorylates PIP2 to PIP3, Mus musculus"
xref: Reactome:REACT_6223 "Phosphorylation of PIP2 to PIP3 by Dp110, Drosophila melanogaster"
xref: Reactome:REACT_77031 "CD28 bound PI3K phosphorylates PIP2 to PIP3, Xenopus tropicalis"
xref: Reactome:REACT_77523 "PI3K catalyses the phosphorylation of PIP2 to PIP3, Bos taurus"
xref: Reactome:REACT_77937 "PI3K phosphorylates PIP2 to PIP3, Gallus gallus"
xref: Reactome:REACT_79149 "PI3K catalyses the phosphorylation of PIP2 to PIP3, Rattus norvegicus"
xref: Reactome:REACT_80332 "PIK3 converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3), Canis familiaris"
xref: Reactome:REACT_81604 "PI3K alpha, beta, gamma convert PIP2 to PIP3, Taeniopygia guttata"
xref: Reactome:REACT_81757 "CD28 bound PI3K phosphorylates PIP2 to PIP3, Gallus gallus"
xref: Reactome:REACT_83904 "PIK3 converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3), Bos taurus"
xref: Reactome:REACT_84127 "PI3K produces PIP3 and other phosphatidyl inositides, Taeniopygia guttata"
xref: Reactome:REACT_84814 "PIK3 converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3), Mus musculus"
xref: Reactome:REACT_85588 "PI3K alpha, beta, gamma convert PIP2 to PIP3, Caenorhabditis elegans"
xref: Reactome:REACT_87888 "PI3K phosphorylates PIP2 to PIP3, Canis familiaris"
xref: Reactome:REACT_88487 "PI3K alpha, beta, gamma convert PIP2 to PIP3, Drosophila melanogaster"
xref: Reactome:REACT_88994 "PI3K produces PIP3 and other phosphatidyl inositides, Rattus norvegicus"
xref: Reactome:REACT_90594 "PIK3 converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3), Gallus gallus"
xref: Reactome:REACT_91594 "PI3K produces PIP3 and other phosphatidyl inositides, Gallus gallus"
xref: Reactome:REACT_92719 "PI3K alpha, beta, gamma convert PIP2 to PIP3, Gallus gallus"
xref: Reactome:REACT_92772 "PI3K alpha, beta, gamma convert PIP2 to PIP3, Canis familiaris"
xref: Reactome:REACT_93245 "PI3K catalyses the phosphorylation of PIP2 to PIP3, Gallus gallus"
xref: Reactome:REACT_93516 "CD28 bound PI3K phosphorylates PIP2 to PIP3, Bos taurus"
xref: Reactome:REACT_93862 "PI3K phosphorylates PIP2 to PIP3, Rattus norvegicus"
xref: Reactome:REACT_94133 "PIK3 converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3), Danio rerio"
xref: Reactome:REACT_94856 "PI3K phosphorylates PIP2 to PIP3, Mus musculus"
xref: Reactome:REACT_94871 "PI3K produces PIP3 and other phosphatidyl inositides, Canis familiaris"
xref: Reactome:REACT_94989 "PI3K alpha, beta, gamma convert PIP2 to PIP3, Danio rerio"
xref: Reactome:REACT_95321 "PI3K catalyses the phosphorylation of PIP2 to PIP3, Canis familiaris"
xref: Reactome:REACT_95580 "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3, Bos taurus"
xref: Reactome:REACT_97567 "PI3K produces PIP3 and other phosphatidyl inositides, Bos taurus"
xref: Reactome:REACT_98424 "PI3K alpha, beta, gamma convert PIP2 to PIP3, Bos taurus"
xref: Reactome:REACT_98754 "PI3K phosphorylates PIP2 to PIP3, Bos taurus"
xref: Reactome:REACT_99739 "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3, Xenopus tropicalis"
xref: RHEA:21295
is_a: GO:0035004 ! phosphatidylinositol 3-kinase activity
is_a: GO:0052813 ! phosphatidylinositol bisphosphate kinase activity

[Term]
id: GO:0046935
name: 1-phosphatidylinositol-3-kinase regulator activity
namespace: molecular_function
def: "Modulates the activity of the enzyme 1-phosphatidylinositol-3-kinase activity." [GOC:ai]
comment: See also the molecular function term '1-phosphatidylinositol-3-kinase activity ; GO:0016303'.
synonym: "1-phosphatidylinositol 3-kinase regulator activity" EXACT []
synonym: "phosphatidylinositol 3-kinase, class I, regulator activity" NARROW []
is_a: GO:0035014 ! phosphatidylinositol 3-kinase regulator activity
relationship: regulates GO:0016303 ! 1-phosphatidylinositol-3-kinase activity

[Term]
id: GO:0046936
name: deoxyadenosine deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: deoxyadenosine + H2O = deoxyinosine + NH3." [EC:3.5.4.4, GOC:ai]
synonym: "deoxyadenosine deaminase reaction" EXACT []
xref: MetaCyc:ADDALT-RXN
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0046937
name: phytochelatin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phytochelatins, any of a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes. The structure is of the type (gamma-glutamyl-cysteinyl)n-glycine, where n is 2 to 11." [ISBN:0198506732]
subset: gosubset_prok
synonym: "cadystin metabolic process" RELATED [GOC:vw, http://en.wikipedia.org/wiki/Phytochelatin#History]
synonym: "cadystin metabolism" RELATED [GOC:vw, http://en.wikipedia.org/wiki/Phytochelatin#History]
synonym: "phytochelatin metabolism" EXACT []
is_a: GO:0006518 ! peptide metabolic process
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0046938
name: phytochelatin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phytochelatins, any of a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes. The structure is of the type (gamma-glutamyl-cysteinyl)n-glycine, where n is 2 to 11." [ISBN:0198506732]
subset: gosubset_prok
synonym: "cadystin biosynthetic process" RELATED [GOC:vw, http://en.wikipedia.org/wiki/Phytochelatin#History]
synonym: "phytochelatin anabolism" EXACT []
synonym: "phytochelatin biosynthesis" EXACT []
synonym: "phytochelatin formation" EXACT []
synonym: "phytochelatin synthesis" EXACT []
is_a: GO:0043043 ! peptide biosynthetic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:0046937 ! phytochelatin metabolic process

[Term]
id: GO:0046939
name: nucleotide phosphorylation
namespace: biological_process
def: "The process of introducing one or more phosphate groups into a nucleotide to produce a phosphorylated nucleoside." [GOC:ai]
subset: gosubset_prok
is_a: GO:0009117 ! nucleotide metabolic process
is_a: GO:0016310 ! phosphorylation

[Term]
id: GO:0046940
name: nucleoside monophosphate phosphorylation
namespace: biological_process
def: "The process of introducing one or more phosphate groups into a nucleoside monophosphate to produce a polyphosphorylated nucleoside." [GOC:ai]
subset: gosubset_prok
is_a: GO:0009123 ! nucleoside monophosphate metabolic process
is_a: GO:0009165 ! nucleotide biosynthetic process

[Term]
id: GO:0046941
name: azetidine-2-carboxylic acid acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-azetidine-2-carboxylic acid + acetyl-CoA = CoA-SH + N-acetyl azetidine-2-carboxylic acid." [PMID:12761200]
xref: EC:2.3.1.-
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0046942
name: carboxylic acid transport
namespace: biological_process
def: "The directed movement of carboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015849 ! organic acid transport

[Term]
id: GO:0046943
name: carboxylic acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of carboxylic acids from one side of the membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:ai]
subset: gosubset_prok
xref: Reactome:REACT_16889 "Exchange of isocitrate and 2-oxoglutarate across the peroxisomal membrane, Homo sapiens"
is_a: GO:0005342 ! organic acid transmembrane transporter activity
is_a: GO:0008514 ! organic anion transmembrane transporter activity
relationship: part_of GO:1905039 ! carboxylic acid transmembrane transport

[Term]
id: GO:0046944
name: protein carbamoylation
namespace: biological_process
def: "The addition of a carbamoyl group to a protein amino acid. A carbamoyl group is the acyl group -CO-NH2." [GOC:ai]
subset: gosubset_prok
synonym: "protein amino acid carbamoylation" EXACT [GOC:bf]
is_a: GO:0006464 ! cellular protein modification process

[Term]
id: GO:0046945
name: N-terminal peptidyl-alanine N-carbamoylation
namespace: biological_process
def: "The carbamylation of the N-terminal alanine of proteins to form the derivative N-carbamoyl-L-alanine." [RESID:AA0343]
subset: gosubset_prok
synonym: "N-terminal peptidyl-alanine N-carbamylation" RELATED []
xref: RESID:AA0343
is_a: GO:0018194 ! peptidyl-alanine modification
is_a: GO:0046944 ! protein carbamoylation
is_a: GO:0050990 ! N-terminal protein amino acid carbamoylation

[Term]
id: GO:0046946
name: hydroxylysine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving hydroxylysine (5-hydroxy-2,6-diaminohexanoic acid), a chiral alpha-amino acid. Hydroxylysine is found in collagen and commonly has galactose and then glucose added sequentially by glycosyltransferases." [ISBN:0198506732, PubChem_Compound:1029]
subset: gosubset_prok
synonym: "hydroxylysine metabolism" EXACT []
is_a: GO:0006575 ! cellular modified amino acid metabolic process
is_a: GO:0009066 ! aspartate family amino acid metabolic process

[Term]
id: GO:0046947
name: hydroxylysine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of hydroxylysine (5-hydroxy-2,6-diaminohexanoic acid), a chiral alpha-amino acid." [ISBN:0198506732]
subset: gosubset_prok
synonym: "hydroxylysine anabolism" EXACT []
synonym: "hydroxylysine biosynthesis" EXACT []
synonym: "hydroxylysine formation" EXACT []
synonym: "hydroxylysine synthesis" EXACT []
is_a: GO:0009067 ! aspartate family amino acid biosynthetic process
is_a: GO:0042398 ! cellular modified amino acid biosynthetic process
is_a: GO:0046946 ! hydroxylysine metabolic process

[Term]
id: GO:0046948
name: hydroxylysine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of hydroxylysine (5-hydroxy-2,6-diaminohexanoic acid), a chiral alpha-amino acid." [ISBN:0198506732]
subset: gosubset_prok
synonym: "hydroxylysine breakdown" EXACT []
synonym: "hydroxylysine catabolism" EXACT []
synonym: "hydroxylysine degradation" EXACT []
is_a: GO:0009068 ! aspartate family amino acid catabolic process
is_a: GO:0042219 ! cellular modified amino acid catabolic process
is_a: GO:0046946 ! hydroxylysine metabolic process

[Term]
id: GO:0046949
name: fatty-acyl-CoA biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group." [ISBN:0198506732]
subset: gosubset_prok
synonym: "fatty acyl CoA biosynthetic process" EXACT [GOC:curators]
synonym: "fatty-acyl-CoA anabolism" EXACT []
synonym: "fatty-acyl-CoA biosynthesis" EXACT []
synonym: "fatty-acyl-CoA formation" EXACT []
synonym: "fatty-acyl-CoA synthesis" EXACT []
is_a: GO:0035337 ! fatty-acyl-CoA metabolic process
is_a: GO:0071616 ! acyl-CoA biosynthetic process

[Term]
id: GO:0046950
name: cellular ketone body metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone, as carried out by individual cells. Although 3-hydroxybutyrate is not a ketone, it is classed as a ketone body because it exists in an equilibrium with acetoacetate. Ketone bodies may accumulate in excessive amounts in the body in starvation, diabetes mellitus or in other defects of carbohydrate metabolism." [ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
synonym: "cellular ketone body metabolism" EXACT []
xref: Reactome:REACT_100444 "Ketone body metabolism, Caenorhabditis elegans"
xref: Reactome:REACT_101523 "Ketone body metabolism, Danio rerio"
xref: Reactome:REACT_107371 "Ketone body metabolism, Sus scrofa"
xref: Reactome:REACT_109409 "Ketone body metabolism, Mus musculus"
xref: Reactome:REACT_109752 "Ketone body metabolism, Mycobacterium tuberculosis"
xref: Reactome:REACT_110395 "Ketone body metabolism, Oryza sativa"
xref: Reactome:REACT_110725 "Ketone body metabolism, Xenopus tropicalis"
xref: Reactome:REACT_110872 "Ketone body metabolism, Bos taurus"
xref: Reactome:REACT_1861 "Ketone body metabolism, Homo sapiens"
xref: Reactome:REACT_29105 "Ketone body metabolism, Gallus gallus"
xref: Reactome:REACT_29141 "Ketone body metabolism, Taeniopygia guttata"
xref: Reactome:REACT_29697 "Ketone body metabolism, Canis familiaris"
xref: Reactome:REACT_31341 "Ketone body metabolism, Plasmodium falciparum"
xref: Reactome:REACT_34650 "Ketone body metabolism, Schizosaccharomyces pombe"
xref: Reactome:REACT_77702 "Ketone body metabolism, Saccharomyces cerevisiae"
xref: Reactome:REACT_78769 "Ketone body metabolism, Arabidopsis thaliana"
xref: Reactome:REACT_80825 "Ketone body metabolism, Drosophila melanogaster"
xref: Reactome:REACT_85192 "Ketone body metabolism, Dictyostelium discoideum"
xref: Reactome:REACT_89476 "Ketone body metabolism, Escherichia coli"
xref: Reactome:REACT_90520 "Ketone body metabolism, Rattus norvegicus"
xref: Reactome:REACT_95478 "Ketone body metabolism, Staphylococcus aureus N315"
is_a: GO:0044237 ! cellular metabolic process
is_a: GO:0044281 ! small molecule metabolic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0046951
name: ketone body biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Biosynthesis involves the formation of hydroxymethylglutaryl-CoA, which is cleaved to acetate and acetyl-CoA." [ISBN:0198506732]
subset: gosubset_prok
synonym: "ketone body anabolism" EXACT []
synonym: "ketone body biosynthesis" EXACT []
synonym: "ketone body formation" EXACT []
synonym: "ketone body synthesis" EXACT []
xref: Reactome:REACT_103709 "Synthesis of Ketone Bodies, Gallus gallus"
xref: Reactome:REACT_105780 "Synthesis of Ketone Bodies, Canis familiaris"
xref: Reactome:REACT_106368 "Synthesis of Ketone Bodies, Rattus norvegicus"
xref: Reactome:REACT_108480 "Synthesis of Ketone Bodies, Bos taurus"
xref: Reactome:REACT_1464 "Synthesis of Ketone Bodies, Homo sapiens"
xref: Reactome:REACT_30077 "Synthesis of Ketone Bodies, Arabidopsis thaliana"
xref: Reactome:REACT_32197 "Synthesis of Ketone Bodies, Mycobacterium tuberculosis"
xref: Reactome:REACT_33657 "Synthesis of Ketone Bodies, Taeniopygia guttata"
xref: Reactome:REACT_33817 "Synthesis of Ketone Bodies, Oryza sativa"
xref: Reactome:REACT_79997 "Synthesis of Ketone Bodies, Drosophila melanogaster"
xref: Reactome:REACT_80882 "Synthesis of Ketone Bodies, Staphylococcus aureus N315"
xref: Reactome:REACT_86263 "Synthesis of Ketone Bodies, Plasmodium falciparum"
xref: Reactome:REACT_87039 "Synthesis of Ketone Bodies, Caenorhabditis elegans"
xref: Reactome:REACT_87704 "Synthesis of Ketone Bodies, Saccharomyces cerevisiae"
xref: Reactome:REACT_88027 "Synthesis of Ketone Bodies, Xenopus tropicalis"
xref: Reactome:REACT_88375 "Synthesis of Ketone Bodies, Dictyostelium discoideum"
xref: Reactome:REACT_91631 "Synthesis of Ketone Bodies, Mus musculus"
xref: Reactome:REACT_92114 "Synthesis of Ketone Bodies, Sus scrofa"
xref: Reactome:REACT_93528 "Synthesis of Ketone Bodies, Escherichia coli"
xref: Reactome:REACT_97850 "Synthesis of Ketone Bodies, Schizosaccharomyces pombe"
xref: Reactome:REACT_99664 "Synthesis of Ketone Bodies, Danio rerio"
is_a: GO:0044249 ! cellular biosynthetic process
is_a: GO:0044283 ! small molecule biosynthetic process
is_a: GO:0046950 ! cellular ketone body metabolic process
is_a: GO:1901576 ! organic substance biosynthetic process
is_a: GO:1902224 ! ketone body metabolic process

[Term]
id: GO:0046952
name: ketone body catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Ketone bodies can be used as an energy source as an alternative to glucose. Utilization of ketone bodies in peripheral tissues involves conversion of acetoacetate to acetoacetyl-CoA, which is then converted to two molecules of acetyl-CoA." [ISBN:0198506732]
subset: gosubset_prok
synonym: "ketone body breakdown" EXACT []
synonym: "ketone body catabolism" EXACT []
synonym: "ketone body degradation" EXACT []
xref: Reactome:REACT_104363 "Utilization of Ketone Bodies, Saccharomyces cerevisiae"
xref: Reactome:REACT_104659 "Utilization of Ketone Bodies, Canis familiaris"
xref: Reactome:REACT_107143 "Utilization of Ketone Bodies, Gallus gallus"
xref: Reactome:REACT_107185 "Utilization of Ketone Bodies, Mycobacterium tuberculosis"
xref: Reactome:REACT_111032 "Utilization of Ketone Bodies, Taeniopygia guttata"
xref: Reactome:REACT_31636 "Utilization of Ketone Bodies, Caenorhabditis elegans"
xref: Reactome:REACT_32601 "Utilization of Ketone Bodies, Drosophila melanogaster"
xref: Reactome:REACT_33137 "Utilization of Ketone Bodies, Sus scrofa"
xref: Reactome:REACT_59 "Utilization of Ketone Bodies, Homo sapiens"
xref: Reactome:REACT_81278 "Utilization of Ketone Bodies, Plasmodium falciparum"
xref: Reactome:REACT_85186 "Utilization of Ketone Bodies, Danio rerio"
xref: Reactome:REACT_86132 "Utilization of Ketone Bodies, Bos taurus"
xref: Reactome:REACT_86819 "Utilization of Ketone Bodies, Schizosaccharomyces pombe"
xref: Reactome:REACT_89256 "Utilization of Ketone Bodies, Mus musculus"
xref: Reactome:REACT_89300 "Utilization of Ketone Bodies, Dictyostelium discoideum"
xref: Reactome:REACT_93975 "Utilization of Ketone Bodies, Escherichia coli"
xref: Reactome:REACT_94718 "Utilization of Ketone Bodies, Xenopus tropicalis"
xref: Reactome:REACT_95153 "Utilization of Ketone Bodies, Rattus norvegicus"
is_a: GO:0044248 ! cellular catabolic process
is_a: GO:0044282 ! small molecule catabolic process
is_a: GO:0046950 ! cellular ketone body metabolic process
is_a: GO:1901575 ! organic substance catabolic process
is_a: GO:1902224 ! ketone body metabolic process

[Term]
id: GO:0046956
name: positive phototaxis
namespace: biological_process
alt_id: GO:0046954
def: "The directed movement of a cell or organism towards a source of light." [GOC:ai]
synonym: "positive phototactic behavior" EXACT []
synonym: "positive phototactic behaviour" EXACT []
synonym: "positive taxis in response to light" EXACT []
is_a: GO:0042331 ! phototaxis
is_a: GO:0052128 ! positive energy taxis

[Term]
id: GO:0046957
name: negative phototaxis
namespace: biological_process
alt_id: GO:0046955
def: "The directed movement of a cell or organism away from a source of light." [GOC:ai]
synonym: "negative phototactic behavior" EXACT []
synonym: "negative phototactic behaviour" EXACT []
synonym: "negative taxis in response to light" EXACT []
is_a: GO:0042331 ! phototaxis
is_a: GO:0052129 ! negative energy taxis

[Term]
id: GO:0046958
name: nonassociative learning
namespace: biological_process
def: "A simple form of learning whereby the repeated presence of a stimulus leads to a change in the probability or strength of the response to that stimulus. There is no association of one type of stimulus with another, rather it is a generalized response to the environment." [ISBN:0582227089]
synonym: "unconditional response" EXACT []
is_a: GO:0007612 ! learning

[Term]
id: GO:0046959
name: habituation
namespace: biological_process
def: "A decrease in a behavioral response to a repeated stimulus. This is exemplified by the failure of a person to show a startle response to a loud noise that has been repeatedly presented." [ISBN:0582227089]
xref: Wikipedia:Habituation
is_a: GO:0046958 ! nonassociative learning

[Term]
id: GO:0046960
name: sensitization
namespace: biological_process
def: "An increased in a behavioral response to a repeated stimulus. For example, a shock to the tail of the marine snail Aplysia, to which the snail responds by withdrawing its gill, will result in increased gill withdrawal the next time the skin is touched." [ISBN:0582227089]
xref: Wikipedia:Sensitization
is_a: GO:0046958 ! nonassociative learning

[Term]
id: GO:0046961
name: proton-transporting ATPase activity, rotational mechanism
namespace: molecular_function
def: "Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism." [EC:3.6.3.14]
subset: gosubset_prok
synonym: "ATP phosphohydrolase (H+-transporting) activity" EXACT [EC:3.6.3.14]
synonym: "ATP synthase activity" BROAD [EC:3.6.3.14]
synonym: "bacterial Ca2+/Mg2+ ATPase" NARROW [EC:3.6.3.14]
synonym: "chloroplast ATPase activity" NARROW [EC:3.6.3.14]
synonym: "coupling factors (Fo, F1 and CF1)" RELATED [EC:3.6.3.14]
synonym: "F(0)F(1)-ATPase activity" NARROW [EC:3.6.3.14]
synonym: "F(1)-ATPase activity" NARROW [EC:3.6.3.14]
synonym: "F(o)F(1)-ATPase activity" NARROW [EC:3.6.3.14]
synonym: "F0F1-ATPase" NARROW [EC:3.6.3.14]
synonym: "F1-ATPase" NARROW [EC:3.6.3.14]
synonym: "FoF1-ATPase" NARROW [EC:3.6.3.14]
synonym: "H(+)-transporting ATP synthase activity" EXACT [EC:3.6.3.14]
synonym: "H(+)-transporting ATPase activity" BROAD [EC:3.6.3.14]
synonym: "H+-transporting ATPase activity" EXACT [EC:3.6.3.14]
synonym: "H+-transporting two-sector ATPase" NARROW [EC:3.6.3.14]
synonym: "hydrogen ion translocating A-type ATPase activity" NARROW []
synonym: "hydrogen ion translocating F-type ATPase activity" NARROW []
synonym: "hydrogen ion translocating V-type ATPase activity" NARROW []
synonym: "hydrogen ion transporting ATPase activity, rotational mechanism" EXACT []
synonym: "hydrogen ion transporting two-sector ATPase activity" NARROW []
synonym: "mitochondrial ATPase activity" NARROW [EC:3.6.3.14]
xref: MetaCyc:ATPSYN-RXN
is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity
is_a: GO:0036442 ! hydrogen-exporting ATPase activity
is_a: GO:0044769 ! ATPase activity, coupled to transmembrane movement of ions, rotational mechanism

[Term]
id: GO:0046962
name: sodium-transporting ATPase activity, rotational mechanism
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out), by a rotational mechanism." [EC:3.6.3.15]
synonym: "ATP phosphohydrolase (Na+-transporting) activity" EXACT [EC:3.6.3.15]
synonym: "ATP synthase, sodium ion specific activity" EXACT [EC:3.6.3.145]
synonym: "Na(+)-translocating ATPase activity" BROAD [EC:3.6.3.15]
synonym: "Na(+)-transporting two-sector ATPase activity" EXACT [EC:3.6.3.15]
synonym: "Na+-translocating ATPase activity" EXACT [EC:3.6.3.15]
synonym: "Na+-translocating F1Fo-ATPase" NARROW [EC:3.6.3.15]
synonym: "Na+-transporting two-sector ATPase" NARROW [EC:3.6.3.15]
synonym: "sodium transporting ATPase activity, rotational mechanism" EXACT []
synonym: "sodium-translocating F-type ATPase activity" NARROW []
synonym: "sodium-translocating V-type ATPase activity" NARROW []
synonym: "sodium-transporting two-sector ATPase activity" NARROW []
synonym: "vacuolar-type Na+-ATPase" NARROW [EC:3.6.3.15]
synonym: "vacuolar-type Na+-translocating ATPase" NARROW [EC:3.6.3.15]
xref: MetaCyc:3.6.3.15-RXN
is_a: GO:0015081 ! sodium ion transmembrane transporter activity
is_a: GO:0019829 ! cation-transporting ATPase activity
is_a: GO:0044769 ! ATPase activity, coupled to transmembrane movement of ions, rotational mechanism

[Term]
id: GO:0046963
name: 3'-phosphoadenosine 5'-phosphosulfate transport
namespace: biological_process
def: "The directed movement of 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride synthesized from adenosine 5'-phosphosulfate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [ISBN:0198506732]
synonym: "3'-phosphoadenosine 5'-phosphosulphate transport" EXACT []
synonym: "adenosine 3'-phosphate 5'-phosphosulfate transport" EXACT []
synonym: "PAPS transport" EXACT []
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015858 ! nucleoside transport
is_a: GO:0015868 ! purine ribonucleotide transport
is_a: GO:0051503 ! adenine nucleotide transport
is_a: GO:0072348 ! sulfur compound transport

[Term]
id: GO:0046964
name: 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride synthesized from adenosine 5'-phosphosulfate, from one side of a membrane to the other." [ISBN:0198506732]
synonym: "3'-phosphoadenosine 5'-phosphosulphate transporter activity" EXACT []
synonym: "adenosine 3'-phosphate 5'-phosphosulfate transmembrane transporter activity" EXACT []
synonym: "PAPS transporter activity" EXACT []
xref: Reactome:REACT_22255 "SLC35B2 and SLC35B3 mediate the antiport of PAPS into the Golgi lumen in exchange for PAP, Homo sapiens"
is_a: GO:0000295 ! adenine nucleotide transmembrane transporter activity
is_a: GO:0005346 ! purine ribonucleotide transmembrane transporter activity
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015211 ! purine nucleoside transmembrane transporter activity
is_a: GO:1901682 ! sulfur compound transmembrane transporter activity
relationship: part_of GO:1902559 ! 3'-phospho-5'-adenylyl sulfate transmembrane transport

[Term]
id: GO:0046965
name: retinoid X receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a retinoid X receptor." [GOC:ai]
synonym: "RXR binding" EXACT []
is_a: GO:0042974 ! retinoic acid receptor binding

[Term]
id: GO:0046966
name: thyroid hormone receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a thyroid hormone receptor." [GOC:ai]
synonym: "ligand-dependent thyroid hormone receptor interactor activity" NARROW []
is_a: GO:0008134 ! transcription factor binding
is_a: GO:0035257 ! nuclear hormone receptor binding

[Term]
id: GO:0046967
name: cytosol to ER transport
namespace: biological_process
def: "The directed movement of substances from the cytosol to the endoplasmic reticulum of a cell." [GOC:ai]
synonym: "cytosol to endoplasmic reticulum transport" EXACT []
is_a: GO:1902582 ! single-organism intracellular transport
relationship: occurs_in GO:0005737 ! cytoplasm

[Term]
id: GO:0046968
name: peptide antigen transport
namespace: biological_process
def: "The directed movement of a peptide antigen into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein." [GOC:add, ISBN:0781735149, PMID:15771591]
is_a: GO:0015833 ! peptide transport
relationship: part_of GO:0048002 ! antigen processing and presentation of peptide antigen

[Term]
id: GO:0046969
name: NAD-dependent histone deacetylase activity (H3-K9 specific)
namespace: molecular_function
def: "Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + H2O = histone H3 L-lysine (position 9) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 9 of the histone H3 protein." [EC:3.5.1.17, RHEA:24551]
is_a: GO:0017136 ! NAD-dependent histone deacetylase activity
is_a: GO:0032129 ! histone deacetylase activity (H3-K9 specific)

[Term]
id: GO:0046970
name: NAD-dependent histone deacetylase activity (H4-K16 specific)
namespace: molecular_function
def: "Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + H2O = histone H4 L-lysine (position 16) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 16 of the histone H4 protein." [EC:3.5.1.17, GOC:vw, RHEA:24551]
is_a: GO:0017136 ! NAD-dependent histone deacetylase activity
is_a: GO:0034739 ! histone deacetylase activity (H4-K16 specific)

[Term]
id: GO:0046972
name: histone acetyltransferase activity (H4-K16 specific)
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 16) = CoA + histone H4 N6-acetyl-L-lysine (position 16). This reaction represents the addition of an acetyl group to the lysine at position 16 of histone H4." [EC:2.3.1.48]
synonym: "histone lysine acetyltransferase activity (H4-K16 specific)" EXACT []
is_a: GO:0010485 ! H4 histone acetyltransferase activity
relationship: part_of GO:0043984 ! histone H4-K16 acetylation

[Term]
id: GO:0046973
name: obsolete histone lysine N-methyltransferase activity (H3-K24 specific)
namespace: molecular_function
def: "OBSOLETE. Catalysis of the addition of a methyl group onto lysine at position 24 of the histone H3 protein." [GOC:ai]
comment: This term was made obsolete because there is no lysine at position 24 of histone H3.
synonym: "histone lysine N-methyltransferase activity (H3-K24 specific)" EXACT []
is_obsolete: true
consider: GO:0042800

[Term]
id: GO:0046974
name: histone methyltransferase activity (H3-K9 specific)
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 9) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 9). This reaction is the addition of a methyl group onto lysine at position 9 of the histone H3 protein." [GOC:ai]
synonym: "histone lysine N-methyltransferase activity (H3-K9 specific)" EXACT []
synonym: "histone methylase activity (H3-K9 specific)" EXACT [GOC:mah]
is_a: GO:0018024 ! histone-lysine N-methyltransferase activity
relationship: part_of GO:0051567 ! histone H3-K9 methylation

[Term]
id: GO:0046975
name: histone methyltransferase activity (H3-K36 specific)
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 36) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 36). This reaction is the addition of a methyl group onto lysine at position 36 of the histone H3 protein." [GOC:ai]
synonym: "histone lysine N-methyltransferase activity (H3-K36 specific)" EXACT []
synonym: "histone methylase activity (H3-K36 specific)" EXACT [GOC:mah]
is_a: GO:0018024 ! histone-lysine N-methyltransferase activity
relationship: part_of GO:0010452 ! histone H3-K36 methylation

[Term]
id: GO:0046976
name: histone methyltransferase activity (H3-K27 specific)
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 27) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 27). This reaction is the addition of a methyl group onto lysine at position 27 of the histone H3 protein." [GOC:ai]
synonym: "histone lysine N-methyltransferase activity (H3-K27 specific)" EXACT []
synonym: "histone methylase activity (H3-K27 specific)" EXACT [GOC:mah]
is_a: GO:0018024 ! histone-lysine N-methyltransferase activity
relationship: part_of GO:0070734 ! histone H3-K27 methylation

[Term]
id: GO:0046977
name: TAP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with TAP protein, transporter associated with antigen processing protein. TAP protein is a heterodimeric peptide transporter consisting of the subunits TAP1 and TAP2." [PMID:11133832]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0046978
name: TAP1 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the TAP1 subunit of TAP (transporter associated with antigen processing) protein." [PMID:11133832]
is_a: GO:0046977 ! TAP binding

[Term]
id: GO:0046979
name: TAP2 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the TAP2 subunit of TAP (transporter associated with antigen processing) protein." [PMID:11133832]
is_a: GO:0046977 ! TAP binding

[Term]
id: GO:0046980
name: tapasin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with tapasin, a member of the MHC class I loading complex which bridges the TAP peptide transporter to class I molecules." [PMID:12594855]
synonym: "TAP binding protein binding" EXACT [HGNC:11566]
synonym: "TAPBP binding" RELATED [HGNC:11566]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0046981
name: beta-1,4-mannosylglycolipid beta-1,3-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of N-acetylglucosamine (GlcNAc) in a beta-1,3 linkage to the mannose(beta-1,4)Glc disaccharide core of glycolipids." [GOC:bf, PMID:12130631, PMID:12130651]
synonym: "UDP-N-acetylglucosamine:beta-D-mannosyl-glycolipid beta-1,3-N-acetylglucosaminyltransferase activity" EXACT []
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0046982
name: protein heterodimerization activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai]
subset: goslim_chembl
is_a: GO:0046983 ! protein dimerization activity

[Term]
id: GO:0046983
name: protein dimerization activity
namespace: molecular_function
def: "The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0046984
name: regulation of hemoglobin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin." [GOC:ai]
synonym: "regulation of haemoglobin biosynthesis" EXACT []
synonym: "regulation of haemoglobin biosynthetic process" EXACT []
synonym: "regulation of hemoglobin anabolism" EXACT []
synonym: "regulation of hemoglobin biosynthesis" EXACT []
synonym: "regulation of hemoglobin formation" EXACT []
synonym: "regulation of hemoglobin synthesis" EXACT []
is_a: GO:0051246 ! regulation of protein metabolic process
is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042541 ! hemoglobin biosynthetic process
relationship: regulates GO:0042541 ! hemoglobin biosynthetic process

[Term]
id: GO:0046985
name: positive regulation of hemoglobin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin." [GOC:ai]
synonym: "activation of hemoglobin biosynthetic process" NARROW []
synonym: "positive regulation of haemoglobin biosynthesis" EXACT []
synonym: "positive regulation of haemoglobin biosynthetic process" EXACT []
synonym: "positive regulation of hemoglobin anabolism" EXACT []
synonym: "positive regulation of hemoglobin biosynthesis" EXACT []
synonym: "positive regulation of hemoglobin formation" EXACT []
synonym: "positive regulation of hemoglobin synthesis" EXACT []
synonym: "stimulation of hemoglobin biosynthetic process" NARROW []
synonym: "up regulation of hemoglobin biosynthetic process" EXACT []
synonym: "up-regulation of hemoglobin biosynthetic process" EXACT []
synonym: "upregulation of hemoglobin biosynthetic process" EXACT []
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0046984 ! regulation of hemoglobin biosynthetic process
is_a: GO:0051247 ! positive regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042541 ! hemoglobin biosynthetic process
relationship: positively_regulates GO:0042541 ! hemoglobin biosynthetic process

[Term]
id: GO:0046986
name: negative regulation of hemoglobin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin." [GOC:ai]
synonym: "down regulation of hemoglobin biosynthetic process" EXACT []
synonym: "down-regulation of hemoglobin biosynthetic process" EXACT []
synonym: "downregulation of hemoglobin biosynthetic process" EXACT []
synonym: "inhibition of hemoglobin biosynthetic process" NARROW []
synonym: "negative regulation of haemoglobin biosynthesis" EXACT []
synonym: "negative regulation of haemoglobin biosynthetic process" EXACT []
synonym: "negative regulation of hemoglobin anabolism" EXACT []
synonym: "negative regulation of hemoglobin biosynthesis" EXACT []
synonym: "negative regulation of hemoglobin formation" EXACT []
synonym: "negative regulation of hemoglobin synthesis" EXACT []
is_a: GO:0046984 ! regulation of hemoglobin biosynthetic process
is_a: GO:0051248 ! negative regulation of protein metabolic process
is_a: GO:2000113 ! negative regulation of cellular macromolecule biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042541 ! hemoglobin biosynthetic process
relationship: negatively_regulates GO:0042541 ! hemoglobin biosynthetic process

[Term]
id: GO:0046987
name: N-acetyllactosamine beta-1,3-glucuronosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-D-glucuronic acid to N-acetyllactosamine (galactosyl beta-1,4-N-acetylglucosamine)." [GOC:bf, PMID:12511570]
synonym: "galactosyl beta-1,4 N-acetylglucosamine beta-1,3 glucuronosyltransferase activity" EXACT []
is_a: GO:0015020 ! glucuronosyltransferase activity

[Term]
id: GO:0046988
name: asioloorosomucoid beta-1,3-glucuronosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-GlcUA to asioloorosomucoid." [GOC:bf, PMID:12511570]
is_a: GO:0015020 ! glucuronosyltransferase activity

[Term]
id: GO:0046989
name: galactosyl beta-1,3 N-acetylgalactosamine beta-1,3-glucuronosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-GlcUA to the disaccharide galactosyl beta-1,3 N-acetylgalactosamine, a common component of glycoproteins and glycolipids." [GOC:bf, PMID:12511570]
is_a: GO:0015020 ! glucuronosyltransferase activity

[Term]
id: GO:0046990
name: N-hydroxyarylamine O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + an N-hydroxyarylamine = CoA + an N-acetoxyarylamine." [EC:2.3.1.118, MetaCyc:2.3.1.118-RXN]
subset: gosubset_prok
synonym: "acetyl-CoA:N-hydroxyarylamine O-acetyltransferase activity" EXACT [EC:2.3.1.118]
synonym: "arylhydroxamate N,O-acetyltransferase activity" EXACT [EC:2.3.1.118]
synonym: "N-hydroxy-2-aminofluorene-O-acetyltransferase activity" EXACT [EC:2.3.1.118]
xref: EC:2.3.1.118
xref: MetaCyc:2.3.1.118-RXN
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0046992
name: oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y." [GOC:ai]
comment: Note that enzymes of class EC:1.21.99.- should also be annotated to this term.
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with other acceptors" NARROW []
xref: EC:1.21
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0046993
name: oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y and the acceptor is oxygen." [GOC:ai]
subset: gosubset_prok
xref: EC:1.21.3
is_a: GO:0046992 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond

[Term]
id: GO:0046994
name: oxidoreductase activity, acting on hydrogen as donor, with a quinone or similar compound as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces quinone or similar compound." [GOC:jl]
subset: gosubset_prok
xref: EC:1.12.5
is_a: GO:0016695 ! oxidoreductase activity, acting on hydrogen as donor

[Term]
id: GO:0046995
name: oxidoreductase activity, acting on hydrogen as donor, with other known acceptors
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen reduces a known acceptor other than a cytochrome, an iron-sulfur protein, NAD, NADP, or a quinone or similar compound." [GOC:ai]
subset: gosubset_prok
xref: EC:1.12.98
is_a: GO:0016695 ! oxidoreductase activity, acting on hydrogen as donor

[Term]
id: GO:0046996
name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NAD(P)H as one donor, and the other dehydrogenated
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and the latter donor is dehydrogenated." [GOC:mah]
synonym: "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NADH or NADPH as one donor, and the other dehydrogenated" RELATED []
xref: EC:1.14.21
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0046997
name: oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a flavin." [GOC:jl]
subset: gosubset_prok
xref: EC:1.5.8
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0046998
name: (S)-usnate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (6R)-2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)-3-hydroxy-6-methylcyclohexa-2,4-dien-1-one + NAD(+) = (S)-usnate + 2 H(+) + NADH." [EC:1.1.1.199, RHEA:21879]
synonym: "L-usnic acid dehydrogenase activity" EXACT [EC:1.1.1.199]
synonym: "reduced-(S)-usnate:NAD+ oxidoreductase (ether-bond-forming)" EXACT [EC:1.1.1.199]
xref: EC:1.1.1.199
xref: KEGG:R07345
xref: MetaCyc:1.1.1.199-RXN
xref: RHEA:21879
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0046999
name: regulation of conjugation
namespace: biological_process
def: "Any process that modulates the rate or frequency of conjugation, the union or introduction of genetic information from compatible mating types that results in a genetically different individual." [GOC:ai]
subset: gosubset_prok
is_a: GO:0043900 ! regulation of multi-organism process
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000746 ! conjugation
relationship: regulates GO:0000746 ! conjugation

[Term]
id: GO:0047000
name: 2-dehydro-3-deoxy-D-gluconate 6-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate + NADP(+) = (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + H(+) + NADPH." [EC:1.1.1.126, RHEA:15112]
synonym: "2-dehydro-3-deoxy-D-gluconate:NADP+ 6-oxidoreductase activity" EXACT [EC:1.1.1.126]
synonym: "2-keto-3-deoxy-D-gluconate dehydrogenase activity" EXACT [EC:1.1.1.126]
xref: EC:1.1.1.126
xref: KEGG:R01543
xref: MetaCyc:1.1.1.126-RXN
xref: RHEA:15112
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047001
name: 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + 2-dehydro-3-deoxy-D-gluconate = NADH + (4S)-4,6-dihydroxy-2,5-dioxohexanoate." [EC:1.1.1.127, MetaCyc:1.1.1.127-RXN]
synonym: "2-dehydro-3-deoxy-D-gluconate:NAD+ 5-oxidoreductase activity" EXACT [EC:1.1.1.127]
synonym: "2-keto-3-deoxy-D-gluconate (3-deoxy-D-glycero-2,5-hexodiulosonic acid) dehydrogenase activity" EXACT [EC:1.1.1.127]
synonym: "2-keto-3-deoxygluconate (nicotinamide adenine dinucleotide (phosphate)) dehydrogenase activity" EXACT [EC:1.1.1.127]
synonym: "2-keto-3-deoxygluconate 5-dehydrogenase activity" EXACT [EC:1.1.1.127]
synonym: "2-keto-3-deoxygluconate dehydrogenase activity" EXACT [EC:1.1.1.127]
xref: EC:1.1.1.127
xref: MetaCyc:1.1.1.127-RXN
xref: RHEA:24235
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047002
name: L-arabinitol 2-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arabinitol + NAD(+) = L-ribulose + H(+) + NADH." [EC:1.1.1.13, RHEA:21359]
synonym: "L-arabinitol 2-dehydrogenase (ribulose forming) activity" EXACT []
xref: EC:1.1.1.13
xref: KEGG:R02441
xref: MetaCyc:1.1.1.13-RXN
xref: RHEA:21359
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047003
name: dTDP-6-deoxy-L-talose 4-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: dTDP-6-deoxy-L-talose + NADP(+) = dTDP-4-dehydro-6-deoxy-L-mannose + H(+) + NADPH." [EC:1.1.1.134, RHEA:23651]
synonym: "dTDP-6-deoxy-L-talose dehydrogenase (4-reductase)" EXACT [EC:1.1.1.134]
synonym: "dTDP-6-deoxy-L-talose:NADP+ 4-oxidoreductase activity" EXACT [EC:1.1.1.134]
synonym: "TDP-6-deoxy-L-talose dehydrogenase activity" EXACT [EC:1.1.1.134]
synonym: "thymidine diphospho-6-deoxy-L-talose dehydrogenase activity" EXACT [EC:1.1.1.134]
xref: EC:1.1.1.134
xref: KEGG:R02776
xref: MetaCyc:1.1.1.134-RXN
xref: RHEA:23651
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047004
name: UDP-N-acetylglucosamine 6-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + 2 NAD(+) + UDP-N-acetyl-alpha-D-glucosamine = 3 H(+) + 2 NADH + UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate." [EC:1.1.1.136, RHEA:13328]
synonym: "UDP-2-acetamido-2-deoxy-D-glucose:NAD oxidoreductase activity" EXACT [EC:1.1.1.136]
synonym: "UDP-GLcNAc dehydrogenase activity" EXACT [EC:1.1.1.136]
synonym: "UDP-N-acetyl-D-glucosamine:NAD+ 6-oxidoreductase activity" EXACT [EC:1.1.1.136]
synonym: "UDPacetylglucosamine dehydrogenase activity" EXACT [EC:1.1.1.136]
synonym: "uridine diphosphoacetylglucosamine dehydrogenase activity" EXACT [EC:1.1.1.136]
xref: EC:1.1.1.136
xref: KEGG:R00421
xref: MetaCyc:1.1.1.136-RXN
xref: RHEA:13328
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047005
name: 16-alpha-hydroxysteroid dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + 16-alpha-hydroxysteroid = NADPH + H+ + 16-oxosteroid." [EC:1.1.1.147, MetaCyc:1.1.1.147-RXN]
synonym: "16alpha-hydroxy steroid dehydrogenase activity" EXACT [EC:1.1.1.147]
synonym: "16alpha-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.147]
synonym: "16alpha-hydroxysteroid:NAD(P)+ 16-oxidoreductase activity" EXACT [EC:1.1.1.147]
xref: EC:1.1.1.147
xref: MetaCyc:1.1.1.147-RXN
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047006
name: 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(P)+ + 17-alpha,20-alpha-dihydroxypregn-4-en-3-one = NAD(P)H + H+ + 17-alpha-hydroxyprogesterone." [EC:1.1.1.149, MetaCyc:1.1.1.149-RXN]
subset: gosubset_prok
synonym: "20alpha-HSD" RELATED [EC:1.1.1.149]
synonym: "20alpha-HSDH" RELATED [EC:1.1.1.149]
synonym: "20alpha-hydroxy steroid dehydrogenase activity" BROAD [EC:1.1.1.149]
synonym: "20alpha-hydroxysteroid dehydrogenase" BROAD [EC:1.1.1.149]
synonym: "20alpha-hydroxysteroid:NAD(P)+ 20-oxidoreductase activity" BROAD [EC:1.1.1.149]
xref: EC:1.1.1.149
xref: MetaCyc:1.1.1.149-RXN
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047007
name: pregnan-21-ol dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(+) + pregnan-21-ol = H(+) + NADH + pregnan-21-al." [EC:1.1.1.150, RHEA:11451]
synonym: "21-hydroxysteroid dehydrogenase (NAD+) activity" BROAD [EC:1.1.1.50]
synonym: "21-hydroxysteroid:NAD+ 21-oxidoreductase activity" BROAD [EC:1.1.1.150]
xref: EC:1.1.1.150
xref: KEGG:R03043
xref: MetaCyc:1.1.1.150-RXN
xref: RHEA:11451
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047008
name: pregnan-21-ol dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP(+) + pregnan-21-ol = H(+) + NADPH + pregnan-21-al." [EC:1.1.1.151, RHEA:23715]
synonym: "21-hydroxy steroid (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" BROAD [EC:1.1.1.151]
synonym: "21-hydroxy steroid dehydrogenase (nicotinamide adenine dinucleotide phosphate) activity" BROAD [EC:1.1.1.151]
synonym: "21-hydroxy steroid dehydrogenase activity" BROAD [EC:1.1.1.151]
synonym: "21-hydroxysteroid dehydrogenase (NADP+) activity" BROAD [EC:1.1.1.151]
synonym: "21-hydroxysteroid:NADP+ 21-oxidoreductase activity" BROAD [EC:1.1.1.151]
synonym: "NADP-21-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.151]
xref: EC:1.1.1.151
xref: KEGG:R03044
xref: MetaCyc:1.1.1.151-RXN
xref: RHEA:23715
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047009
name: 3-alpha-hydroxy-5-beta-androstane-17-one 3-alpha-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + 3-alpha-hydroxy-5-beta-androstane-17-one = NADH + H+ + 5-beta-androstane-3,17-dione." [EC:1.1.1.152, MetaCyc:1.1.1.152-RXN]
synonym: "3alpha-hydroxy-5beta-androstane-17-one 3alpha-dehydrogenase activity" EXACT [EC:1.1.1.152]
synonym: "3alpha-hydroxy-5beta-steroid dehydrogenase activity" EXACT [EC:1.1.1.152]
synonym: "3alpha-hydroxy-5beta-steroid:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.152]
synonym: "etiocholanolone 3-alpha-dehydrogenase activity" EXACT [EC:1.1.1.152]
synonym: "etiocholanolone 3alpha-dehydrogenase activity" EXACT [EC:1.1.1.152]
xref: EC:1.1.1.152
xref: MetaCyc:1.1.1.152-RXN
xref: RHEA:10359
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047010
name: hydroxycyclohexanecarboxylate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate + NAD(+) = (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate + H(+) + NADH." [EC:1.1.1.166, RHEA:10519]
synonym: "(-)t-3,t-4-dihydroxycyclohexane-c-1-carboxylate-NAD oxidoreductase activity" EXACT [EC:1.1.1.166]
synonym: "(1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.166]
synonym: "dihydroxycyclohexanecarboxylate dehydrogenase activity" EXACT [EC:1.1.1.166]
xref: EC:1.1.1.166
xref: KEGG:R05315
xref: MetaCyc:1.1.1.166-RXN
xref: RHEA:10519
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047011
name: 2-dehydropantolactone reductase (A-specific) activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NADP+." [EC:1.1.1.168, MetaCyc:1.1.1.168-RXN]
synonym: "(R)-pantolactone:NADP+ oxidoreductase (A-specific)" EXACT [EC:1.1.1.168]
synonym: "2-dehydropantoyl-lactone reductase (A-specific) activity" EXACT [EC:1.1.1.168]
synonym: "2-ketopantoyl lactone reductase activity" BROAD [EC:1.1.1.168]
synonym: "2-oxopantoyl lactone reductase" BROAD [EC:1.1.1.168]
synonym: "ketopantoyl lactone reductase activity" BROAD [EC:1.1.1.168]
xref: EC:1.1.1.168
xref: MetaCyc:1.1.1.168-RXN
is_a: GO:0036441 ! 2-dehydropantolactone reductase activity

[Term]
id: GO:0047012
name: sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(P)+ + 3-beta-hydroxy-4-alpha-methyl-5-alpha-cholest-7-ene-4-beta-carboxylate = NAD(P)H + H+ + CO2 + 4-alpha-methyl-5-alpha-cholest-7-en-3-one." [EC:1.1.1.170, MetaCyc:1.1.1.170-RXN]
synonym: "3-beta-hydroxy-4-alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating) activity" EXACT []
synonym: "3-beta-hydroxy-4-beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating) activity" RELATED [EC:1.1.1.170]
synonym: "3-beta-hydroxy-4-beta-methylcholestenoate dehydrogenase activity" RELATED [EC:1.1.1.170]
synonym: "3beta-hydroxy-4alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)" RELATED [EC:1.1.1.170]
synonym: "sterol 4-alpha-carboxylic decarboxylase activity" RELATED [EC:1.1.1.170]
xref: EC:1.1.1.170
xref: MetaCyc:1.1.1.170-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047013
name: cholate 12-alpha dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cholate + NADP(+) = 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH." [EC:1.1.1.176, RHEA:14132]
subset: gosubset_prok
synonym: "12-alpha-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.176]
synonym: "12alpha-hydroxy steroid dehydrogenase activity" BROAD [EC:1.1.1.176]
synonym: "12alpha-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.176]
synonym: "12alpha-hydroxysteroid:NADP+ 12-oxidoreductase activity" BROAD [EC:1.1.1.176]
synonym: "NAD-dependent 12alpha-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.176]
synonym: "NADP-12alpha-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.176]
xref: EC:1.1.1.176
xref: KEGG:R02793
xref: MetaCyc:1.1.1.176-RXN
xref: RHEA:14132
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047014
name: glycerol-3-phosphate 1-dehydrogenase [NADP+] activity
namespace: molecular_function
def: "Catalysis of the reaction: sn-glycerol 3-phosphate + NADP(+) = D-glyceraldehyde 3-phosphate + H(+) + NADPH." [EC:1.1.1.177, RHEA:19776]
synonym: "glycerin-3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.177]
synonym: "glycerol phosphate (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT [EC:1.1.1.177]
synonym: "L-glycerol 3-phosphate:NADP oxidoreductase activity" EXACT [EC:1.1.1.177]
synonym: "NADPH-dependent glycerin-3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.177]
synonym: "sn-glycerol-3-phosphate:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.177]
xref: EC:1.1.1.177
xref: KEGG:R00845
xref: MetaCyc:1.1.1.177-RXN
xref: RHEA:19776
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047015
name: 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + 2-methyl-3-hydroxybutyryl-CoA = NADH + H+ + 2-methylaceto-acetyl-CoA." [EC:1.1.1.178, MetaCyc:1.1.1.178-RXN]
synonym: "(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.178]
synonym: "2-methyl-3-hydroxy-butyryl CoA dehydrogenase activity" EXACT [EC:1.1.1.178]
synonym: "2-methyl-3-hydroxybutyryl coenzyme A dehydrogenase activity" EXACT [EC:1.1.1.178]
synonym: "2-methyl-3-hydroxybutyryl-CoA dehydrogenase activity" EXACT [EC:1.1.1.178]
xref: EC:1.1.1.178
xref: MetaCyc:1.1.1.178-RXN
xref: RHEA:13284
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047016
name: cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + 7-alpha-hydroxycholesterol = NADH + H+ + 7-alpha-hydroxycholest-4-en-3-one." [EC:1.1.1.181, MetaCyc:1.1.1.181-RXN]
synonym: "3-beta-hydroxy-Delta(5)-C(27)-steroid oxidoreductase activity" EXACT [EC:1.1.1.181]
synonym: "3beta-hydroxy-delta5-C27-steroid oxidoreductase" BROAD [EC:1.1.1.181]
synonym: "cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase activity" EXACT [EC:1.1.1.181]
synonym: "cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.181]
xref: EC:1.1.1.181
xref: MetaCyc:1.1.1.181-RXN
xref: RHEA:11899
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047017
name: prostaglandin-F synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate = NADPH + H+ + (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate." [EC:1.1.1.188, MetaCyc:1.1.1.188-RXN]
synonym: "(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP+ 11-oxidoreductase activity" EXACT [EC:1.1.1.188]
synonym: "NADPH-dependent prostaglandin D2 11-keto reductase activity" EXACT [EC:1.1.1.188]
synonym: "PGD(2) 11-ketoreductase activity" EXACT [EC:1.1.1.188]
synonym: "PGD2 11-ketoreductase activity" EXACT [EC:1.1.1.188]
synonym: "PGF synthetase activity" EXACT [EC:1.1.1.188]
synonym: "PGF2alpha synthetase activity" EXACT [EC:1.1.1.188]
synonym: "prostaglandin 11-keto reductase activity" EXACT [EC:1.1.1.188]
synonym: "prostaglandin 11-ketoreductase activity" EXACT [EC:1.1.1.188]
synonym: "prostaglandin D2-ketoreductase activity" EXACT [EC:1.1.1.188]
synonym: "prostaglandin F synthase activity" EXACT [EC:1.1.1.188]
synonym: "prostaglandin F synthetase activity" EXACT [EC:1.1.1.188]
synonym: "prostaglandin-D(2) 11-ketoreductase activity" EXACT [EC:1.1.1.188]
synonym: "prostaglandin-D(2) 11-reductase activity" EXACT [EC:1.1.1.188]
synonym: "prostaglandin-D(2) ketoreductase activity" EXACT [EC:1.1.1.188]
synonym: "prostaglandin-D2 11-ketoreductase activity" EXACT [EC:1.1.1.188]
synonym: "prostaglandin-D2 11-reductase activity" EXACT [EC:1.1.1.188]
synonym: "prostaglandin-D2 ketoreductase activity" EXACT [EC:1.1.1.188]
synonym: "prostaglandin-F synthetase activity" EXACT [EC:1.1.1.188]
synonym: "reductase, 15-hydroxy-11-oxoprostaglandin" EXACT [EC:1.1.1.188]
synonym: "synthetase, prostaglandin F2alpha" EXACT [EC:1.1.1.188]
xref: EC:1.1.1.188
xref: MetaCyc:1.1.1.188-RXN
xref: RHEA:10143
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047018
name: indole-3-acetaldehyde reductase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: indole-3-ethanol + NAD(+) = (indol-3-yl)acetaldehyde + H(+) + NADH." [EC:1.1.1.190, RHEA:14876]
synonym: "(indol-3-yl)ethanol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.190]
synonym: "indole-3-ethanol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.190]
synonym: "indoleacetaldehyde reductase activity" EXACT [EC:1.1.1.190]
xref: EC:1.1.1.190
xref: KEGG:R02679
xref: MetaCyc:1.1.1.190-RXN
xref: RHEA:14876
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047019
name: indole-3-acetaldehyde reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: indole-3-ethanol + NADP(+) = (indol-3-yl)acetaldehyde + H(+) + NADPH." [EC:1.1.1.191, RHEA:17040]
synonym: "(indol-3-yl)ethanol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.191]
synonym: "indole-3-ethanol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.191]
synonym: "indoleacetaldehyde (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.1.1.191]
xref: EC:1.1.1.191
xref: KEGG:R02680
xref: MetaCyc:1.1.1.191-RXN
xref: RHEA:17040
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047020
name: 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate = NADPH + H+ + (5Z,13E)-9-alpha-hydroxy-11,15-dioxoprosta-5,13-dienoate." [EC:1.1.1.196, MetaCyc:1.1.1.196-RXN]
synonym: "(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate:NADP+ 15-oxidoreductase activity" EXACT [EC:1.1.1.196]
synonym: "15-hydroxy PGD2 dehydrogenase activity" EXACT [EC:1.1.1.196]
synonym: "15-hydroxyprostaglandin dehydrogenase (NADP)" EXACT [EC:1.1.1.196]
synonym: "dehydrogenase, 15-hydroxyprostaglandin (nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.1.1.196]
synonym: "dehydrogenase, prostaglandin D2" EXACT [EC:1.1.1.196]
synonym: "NADP-dependent 15-hydroxyprostaglandin dehydrogenase" BROAD [EC:1.1.1.196]
synonym: "NADP-linked 15-hydroxyprostaglandin dehydrogenase" BROAD [EC:1.1.1.196]
synonym: "NADP-linked prostaglandin D2 dehydrogenase activity" EXACT [EC:1.1.1.196]
synonym: "NADP-PGD2 dehydrogenase activity" EXACT [EC:1.1.1.196]
synonym: "NADP-specific 15-hydroxyprostaglandin dehydrogenase" BROAD [EC:1.1.1.196]
synonym: "prostaglandin D2 dehydrogenase activity" EXACT [EC:1.1.1.196]
synonym: "prostaglandin-D 15-dehydrogenase (NADP(+)) activity" EXACT [EC:1.1.1.196]
synonym: "prostaglandin-D 15-dehydrogenase (NADP)" EXACT [EC:1.1.1.196]
synonym: "prostaglandin-D 15-dehydrogenase (NADP+) activity" EXACT [EC:1.1.1.196]
xref: EC:1.1.1.196
xref: MetaCyc:1.1.1.196-RXN
xref: RHEA:20747
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047021
name: 15-hydroxyprostaglandin dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP(+) + prostaglandin E(1) = 15-dehydro-prostaglandin E1 + H(+) + NADPH." [EC:1.1.1.197, RHEA:11639]
synonym: "(13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NADP+ 15-oxidoreductase activity" EXACT [EC:1.1.1.197]
synonym: "NADP-dependent 15-hydroxyprostaglandin dehydrogenase" BROAD [EC:1.1.1.197]
synonym: "NADP-linked 15-hydroxyprostaglandin dehydrogenase" BROAD [EC:1.1.1.197]
synonym: "NADP-specific 15-hydroxyprostaglandin dehydrogenase" BROAD [EC:1.1.1.197]
synonym: "type II 15-hydroxyprostaglandin dehydrogenase activity" EXACT [EC:1.1.1.197]
xref: EC:1.1.1.197
xref: KEGG:R04552
xref: MetaCyc:1.1.1.197-RXN
xref: RHEA:11639
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047022
name: 7-beta-hydroxysteroid dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + a 7-beta-hydroxysteroid = NADPH + H+ + a 7-oxosteroid." [EC:1.1.1.201, MetaCyc:1.1.1.201-RXN]
synonym: "7beta-hydroxysteroid dehydrogenase (NADP+)" EXACT [EC:1.1.1.201]
synonym: "7beta-hydroxysteroid:NADP+ 7-oxidoreductase activity" EXACT [EC:1.1.1.201]
synonym: "NADP-dependent 7-beta-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.201]
synonym: "NADP-dependent 7beta-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.201]
xref: EC:1.1.1.201
xref: MetaCyc:1.1.1.201-RXN
xref: Wikipedia:7beta-hydroxysteroid_dehydrogenase_(NADP+)
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047023
name: androsterone dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione." [EC:1.1.1.209, MetaCyc:1.1.1.209-RXN]
synonym: "3(17)alpha-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.209]
synonym: "3(or 17)-alpha-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.209]
synonym: "3(or 17)alpha-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.209]
synonym: "3(or 17)alpha-hydroxysteroid:NAD(P)+ oxidoreductase activity" BROAD [EC:1.1.1.209]
xref: EC:1.1.1.209
xref: MetaCyc:1.1.1.209-RXN
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047024
name: 5alpha-androstane-3beta,17beta-diol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH." [EC:1.1.1.210, RHEA:16300]
synonym: "3-beta(or 20-alpha)-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.210]
synonym: "3-beta-HSD activity" RELATED [EC:1.1.1.210]
synonym: "3beta(or 20alpha)-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.210]
synonym: "3beta(or 20alpha)-hydroxysteroid:NADP+ oxidoreductase activity" BROAD [EC:1.1.1.210]
synonym: "3beta,20alpha-hydroxysteroid oxidoreductase activity" BROAD [EC:1.1.1.210]
synonym: "dehydrogenase, 3beta,20alpha-hydroxy steroid" BROAD [EC:1.1.1.210]
synonym: "progesterone reductase activity" RELATED [EC:1.1.1.210]
xref: EC:1.1.1.210
xref: KEGG:R04344
xref: MetaCyc:1.1.1.210-RXN
xref: RHEA:16300
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047025
name: 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + OH-acyl-[acyl-carrier protein] = NADH + H+ + B-ketoacyl-[acyl-carrier protein]." [EC:1.1.1.212, MetaCyc:1.1.1.212-RXN]
synonym: "(3R)-3-hydroxyacyl-acyl-carrier-protein:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.212]
synonym: "3-oxoacyl-[acyl-carrier protein] reductase (NADH) activity" EXACT []
synonym: "3-oxoacyl-ACP reductase (NADH) activity" EXACT []
synonym: "3-oxoacyl-acyl carrier protein (reduced nicotinamide adenine dinucleotide) reductase activity" EXACT [EC:1.1.1.212]
synonym: "3-oxoacyl-acyl-carrier-protein reductase (NADH)" EXACT [EC:1.1.1.212]
xref: EC:1.1.1.212
xref: MetaCyc:1.1.1.212-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047026
name: androsterone dehydrogenase (A-specific) activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD(P)+." [EC:1.1.1.213, MetaCyc:1.1.1.213-RXN]
synonym: "3-alpha-hydroxysteroid dehydrogenase (A-specific) activity" BROAD [EC:1.1.1.213]
synonym: "3alpha-hydroxysteroid dehydrogenase (A-specific)" BROAD [EC:1.1.1.213]
synonym: "3alpha-hydroxysteroid:NAD(P)+ oxidoreductase (A-specific)" BROAD [EC:1.1.1.213]
xref: EC:1.1.1.213
xref: MetaCyc:1.1.1.213-RXN
xref: Wikipedia:3alpha-hydroxysteroid_dehydrogenase_(A-specific)
is_a: GO:0047023 ! androsterone dehydrogenase activity

[Term]
id: GO:0047027
name: benzyl-2-methyl-hydroxybutyrate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzyl (2R,3S)-2-methyl-3-hydroxybutanoate + NADP(+) = benzyl 2-methyl-3-oxobutanoate + H(+) + NADPH." [EC:1.1.1.217, RHEA:16408]
synonym: "benzyl 2-methyl-3-hydroxybutyrate dehydrogenase activity" EXACT [EC:1.1.1.217]
synonym: "benzyl-(2R,3S)-2-methyl-3-hydroxybutanoate:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.217]
xref: EC:1.1.1.217
xref: KEGG:R04370
xref: MetaCyc:1.1.1.217-RXN
xref: RHEA:16408
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047028
name: 6-pyruvoyltetrahydropterin 2'-reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + 6-lactoyl-5,6,7,8-tetrahydropterin = NADPH + H+ + 6-pyruvoyltetrahydropterin." [EC:1.1.1.220, MetaCyc:1.1.1.220-RXN]
subset: gosubset_prok
synonym: "6-lactoyl-5,6,7,8-tetrahydropterin:NADP+ 2'-oxidoreductase activity" EXACT [EC:1.1.1.220]
synonym: "6-pyruvoyl tetrahydropterin (2'-oxo)reductase activity" EXACT [EC:1.1.1.220]
synonym: "6-pyruvoyl-tetrahydropterin 2'-reductase activity" EXACT [EC:1.1.1.220]
synonym: "6-pyruvoyltetrahydropterin reductase activity" EXACT [EC:1.1.1.220]
synonym: "6PPH4(2'-oxo) reductase activity" EXACT [EC:1.1.1.220]
synonym: "pyruvoyl-tetrahydropterin reductase activity" EXACT [EC:1.1.1.220]
xref: EC:1.1.1.220
xref: MetaCyc:1.1.1.220-RXN
xref: RHEA:11775
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047029
name: (R)-4-hydroxyphenyllactate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(P)+ + (R)-3-(4-hydroxyphenyl)lactate = NAD(P)H + H+ + 3-(4-hydroxyphenyl)pyruvate." [EC:1.1.1.222, MetaCyc:1.1.1.222-RXN]
synonym: "(R)-3-(4-hydroxyphenyl)lactate:NAD(P)+ 2-oxidoreductase activity" EXACT [EC:1.1.1.222]
synonym: "(R)-aromatic lactate dehydrogenase activity" EXACT [EC:1.1.1.222]
synonym: "D-hydrogenase, D-aryllactate" EXACT [EC:1.1.1.222]
xref: EC:1.1.1.222
xref: MetaCyc:1.1.1.222-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047030
name: 4-hydroxycyclohexanecarboxylate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-4-hydroxycyclohexanecarboxylate + NAD(+) = 4-oxocyclohexanecarboxylate + H(+) + NADH." [EC:1.1.1.226, RHEA:17432]
synonym: "trans-4-hydroxycyclohexanecarboxylate dehydrogenase activity" EXACT [EC:1.1.1.226]
synonym: "trans-4-hydroxycyclohexanecarboxylate:NAD+ 4-oxidoreductase activity" EXACT [EC:1.1.1.226]
xref: EC:1.1.1.226
xref: KEGG:R04307
xref: MetaCyc:1.1.1.226-RXN
xref: RHEA:17432
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047031
name: diethyl 2-methyl-3-oxosuccinate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: diethyl (2R,3R)-2-methyl-3-hydroxysuccinate + NADP(+) = diethyl 2-methyl-3-oxosuccinate + H(+) + NADPH." [EC:1.1.1.229, RHEA:21011]
synonym: "diethyl-(2R,3R)-2-methyl-3-hydroxysuccinate:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.229]
xref: EC:1.1.1.229
xref: KEGG:R04387
xref: MetaCyc:1.1.1.229-RXN
xref: RHEA:21011
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047032
name: 3-alpha-hydroxyglycyrrhetinate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3alpha-hydroxyglycyrrhetinate + NADP(+) = 3-oxoglycyrrhetinate + H(+) + NADPH." [EC:1.1.1.230, RHEA:20819]
synonym: "3alpha-hydroxyglycyrrhetinate dehydrogenase activity" EXACT [EC:1.1.1.230]
synonym: "3alpha-hydroxyglycyrrhetinate:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.230]
xref: EC:1.1.1.230
xref: KEGG:R04099
xref: MetaCyc:1.1.1.230-RXN
xref: RHEA:20819
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047033
name: 15-hydroxyprostaglandin-I dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP(+) + prostaglandin I(2) = 15-dehydro-prostaglandin I(2) + H(+) + NADPH." [EC:1.1.1.231, RHEA:21423]
synonym: "(5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate:NADP+ 15-oxidoreductase activity" EXACT [EC:1.1.1.231]
synonym: "NADP+-dependent PGI2-specific 15-hydroxyprostaglandin dehydrogenase activity" EXACT [EC:1.1.1.231]
synonym: "NADP-linked 15-hydroxyprostaglandin (prostacyclin) dehydrogenase activity" EXACT [EC:1.1.1.231]
synonym: "PG I2 dehydrogenase activity" EXACT [EC:1.1.1.231]
synonym: "prostacyclin dehydrogenase activity" EXACT [EC:1.1.1.231]
xref: EC:1.1.1.231
xref: KEGG:R03520
xref: MetaCyc:1.1.1.231-RXN
xref: RHEA:21423
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047034
name: 15-hydroxyicosatetraenoate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(P)+ + (15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate = NAD(P)H + H+ + 15-oxo-5,8,11-cis-13-trans-icosatetraenoate." [EC:1.1.1.232, MetaCyc:1.1.1.232-RXN]
synonym: "(15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate:NAD(P)+ 15-oxidoreductase activity" EXACT [EC:1.1.1.232]
synonym: "15-hydroxyeicosatetraenoate dehydrogenase activity" EXACT [EC:1.1.1.232]
xref: EC:1.1.1.232
xref: MetaCyc:1.1.1.232-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047035
name: testosterone dehydrogenase (NAD+) activity
namespace: molecular_function
alt_id: GO:0050327
def: "Catalysis of the reaction: testosterone + NAD+ = androst-4-ene-3,17-dione + NADH." [EC:1.1.1.239, MetaCyc:1.1.1.239-RXN]
synonym: "17-beta-HSD activity" BROAD [EC:1.1.1.63]
synonym: "17-ketoreductase activity" BROAD [EC:1.1.1.63]
synonym: "17beta-HSD" RELATED [EC:1.1.1.63]
synonym: "17beta-hydroxysteroid:NAD+ 17-oxidoreductase activity" EXACT [EC:1.1.1.63]
synonym: "3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity" BROAD [EC:1.1.1.239]
synonym: "3alpha(17beta)-HSD" RELATED [EC:1.1.1.239]
synonym: "3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)" BROAD [EC:1.1.1.239]
synonym: "3alpha(or 17beta)-hydroxysteroid:NAD+ oxidoreductase activity" BROAD [EC:1.1.1.239]
synonym: "3alpha,17beta-hydroxy steroid dehydrogenase activity" BROAD [EC:1.1.1.239]
synonym: "testosterone 17-beta-dehydrogenase (NAD+) activity" EXACT []
synonym: "testosterone 17b-dehydrogenase activity" EXACT []
synonym: "testosterone 17beta-dehydrogenase activity" EXACT [EC:1.1.1.63]
xref: EC:1.1.1.239
xref: KEGG:R01836
xref: MetaCyc:1.1.1.239-RXN
xref: MetaCyc:TESTOSTERONE-17-BETA-DEHYDROGENASE-RXN
xref: Reactome:REACT_100682 "Reduction of androstenedione to testosterone, Rattus norvegicus"
xref: Reactome:REACT_106612 "Reduction of androstenedione to testosterone, Canis familiaris"
xref: Reactome:REACT_107687 "Reduction of androstenedione to testosterone, Saccharomyces cerevisiae"
xref: Reactome:REACT_110242 "Reduction of androstenedione to testosterone, Xenopus tropicalis"
xref: Reactome:REACT_110730 "Reduction of androstenedione to testosterone, Sus scrofa"
xref: Reactome:REACT_112435 "Reduction of androstenedione to testosterone, Mycobacterium tuberculosis"
xref: Reactome:REACT_79596 "Reduction of androstenedione to testosterone, Plasmodium falciparum"
xref: Reactome:REACT_80554 "Reduction of androstenedione to testosterone, Schizosaccharomyces pombe"
xref: Reactome:REACT_84684 "Reduction of androstenedione to testosterone, Bos taurus"
xref: Reactome:REACT_87976 "Reduction of androstenedione to testosterone, Dictyostelium discoideum"
xref: Reactome:REACT_89271 "Reduction of androstenedione to testosterone, Mus musculus"
xref: Reactome:REACT_92209 "Reduction of androstenedione to testosterone, Oryza sativa"
xref: Reactome:REACT_96530 "Reduction of androstenedione to testosterone, Danio rerio"
xref: Reactome:REACT_98037 "Reduction of androstenedione to testosterone, Arabidopsis thaliana"
xref: Reactome:REACT_9948 "Reduction of androstenedione to testosterone, Homo sapiens"
xref: RHEA:14932
xref: Wikipedia:3alpha(17beta)-hydroxysteroid_dehydrogenase_(NAD+)
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047036
name: codeinone reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: codeine + NADP(+) = codeinone + H(+) + NADPH." [EC:1.1.1.247, RHEA:19212]
synonym: "codeine:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.247]
xref: EC:1.1.1.247
xref: KEGG:R05124
xref: MetaCyc:1.1.1.247-RXN
xref: RHEA:19212
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047037
name: salutaridine reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: (7S)-salutaridinol + NADP(+) = H(+) + NADPH + salutaridine." [EC:1.1.1.248, RHEA:10111]
synonym: "salutaridinol:NADP+ 7-oxidoreductase activity" EXACT [EC:1.1.1.248]
xref: EC:1.1.1.248
xref: KEGG:R04697
xref: MetaCyc:1.1.1.248-RXN
xref: RHEA:10111
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047038
name: D-arabinitol 2-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-arabinitol + NAD(+) = D-ribulose + H(+) + NADH." [EC:1.1.1.250, RHEA:17392]
synonym: "D-arabinitol 2-dehydrogenase (ribulose-forming) activity" EXACT [EC:1.1.1.250]
synonym: "D-arabinitol:NAD+ 2-oxidoreductase (D-ribulose-forming)" EXACT [EC:1.1.1.250]
xref: EC:1.1.1.250
xref: KEGG:R07134
xref: MetaCyc:1.1.1.250-RXN
xref: RHEA:17392
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047039
name: tetrahydroxynaphthalene reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + scytalone = NADPH + H+ + 1,3,6,8-naphthalenetetrol." [EC:1.1.1.252, MetaCyc:1.1.1.252-RXN]
synonym: "scytalone:NADP+ delta5-oxidoreductase activity" EXACT [EC:1.1.1.252]
synonym: "T4HN reductase activity" EXACT [EC:1.1.1.252]
xref: EC:1.1.1.252
xref: MetaCyc:1.1.1.252-RXN
xref: RHEA:21911
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047040
name: pteridine reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,6,7,8-tetrahydrobiopterin + 2 NADP(+) = biopterin + 2 H(+) + 2 NADPH." [EC:1.5.1.33, RHEA:19512]
comment: Note that this function was formerly EC:1.1.1.253.
synonym: "5,6,7,8-tetrahydrobiopterin:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.33]
synonym: "dihydrobiopterin reduction" RELATED []
synonym: "pteridine reductase 1 activity" NARROW [EC:1.5.1.33e]
synonym: "PTR1" RELATED [EC:1.5.1.33]
synonym: "ptr1 activity" NARROW [EC:1.5.1.33e]
xref: EC:1.5.1.33
xref: KEGG:R01812
xref: MetaCyc:1.1.1.253-RXN
xref: RHEA:19512
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047041
name: (S)-carnitine 3-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-carnitine + NAD(+) = 3-dehydrocarnitine + H(+) + NADH." [EC:1.1.1.254, RHEA:11559]
synonym: "(S)-carnitine:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.254]
synonym: "D-carnitine dehydrogenase activity" EXACT [EC:1.1.1.254]
xref: EC:1.1.1.254
xref: KEGG:R01921
xref: MetaCyc:1.1.1.254-RXN
xref: RHEA:11559
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047042
name: androsterone dehydrogenase (B-specific) activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD(P)+." [EC:1.1.1.50, MetaCyc:1.1.1.50-RXN]
subset: gosubset_prok
synonym: "3-alpha-HSD activity" RELATED [EC:1.1.1.50]
synonym: "3-alpha-hydroxysteroid dehydrogenase (B-specific) activity" BROAD [EC:1.1.1.50]
synonym: "3alpha-HSD" RELATED [EC:1.1.1.50]
synonym: "3alpha-hydroxysteroid dehydrogenase (B-specific)" BROAD [EC:1.1.1.50]
synonym: "3alpha-hydroxysteroid oxidoreductase activity" BROAD [EC:1.1.1.50]
synonym: "3alpha-hydroxysteroid:NAD(P)+ oxidoreductase (B-specific)" BROAD [EC:1.1.1.50]
synonym: "hydroxyprostaglandin dehydrogenase activity" RELATED [EC:1.1.1.50]
synonym: "sterognost 3alpha" RELATED [EC:1.1.1.50]
xref: EC:1.1.1.50
xref: MetaCyc:1.1.1.50-RXN
xref: Wikipedia:3alpha-hydroxysteroid_dehydrogenase_(B-specific)
is_a: GO:0047023 ! androsterone dehydrogenase activity

[Term]
id: GO:0047043
name: 3-alpha-hydroxycholanate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: lithocholate + NAD(+) = 3-oxo-5beta-cholanate + H(+) + NADH." [EC:1.1.1.52, RHEA:19588]
synonym: "3alpha-hydroxy-5beta-cholanate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.52]
synonym: "3alpha-hydroxycholanate dehydrogenase activity" EXACT [EC:1.1.1.52]
synonym: "alpha-hydroxy-cholanate dehydrogenase activity" EXACT [EC:1.1.1.52]
xref: EC:1.1.1.52
xref: KEGG:R04139
xref: MetaCyc:1.1.1.52-RXN
xref: RHEA:19588
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047044
name: androstan-3-alpha,17-beta-diol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + androstan-3-alpha,17-beta-diol = 17-beta-hydroxyandrostan-3-one + NADH + H+." [EC:1.1.1.53, MetaCyc:1.1.1.53-RXN]
subset: gosubset_prok
synonym: "(R)-20-hydroxysteroid dehydrogenase activity" RELATED [EC:1.1.1.53]
synonym: "20beta-HSD" RELATED [EC:1.1.1.53]
synonym: "20beta-hydroxysteroid dehydrogenase activity" RELATED [EC:1.1.1.53]
synonym: "3-alpha(or 20-beta)-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.53]
synonym: "3alpha(or 20beta)-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.53]
synonym: "3alpha(or 20beta)-hydroxysteroid:NAD+ oxidoreductase activity" BROAD [EC:1.1.1.53]
synonym: "3alpha,20beta-hydroxysteroid:NAD+-oxidoreductase activity" BROAD [EC:1.1.1.53]
synonym: "cortisone reductase activity" RELATED [EC:1.1.1.53]
synonym: "dehydrogenase, 20beta-hydroxy steroid" BROAD [EC:1.1.1.53]
synonym: "delta4-3-ketosteroid hydrogenase activity" BROAD [EC:1.1.1.53]
synonym: "NADH-20beta-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.53]
xref: EC:1.1.1.53
xref: MetaCyc:1.1.1.53-RXN
xref: RHEA:22403
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047045
name: testosterone 17-beta-dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + testosterone = NADPH + H+ + androst-4-ene-3,17-dione." [EC:1.1.1.64, MetaCyc:1.1.1.64-RXN]
synonym: "17-ketoreductase activity" BROAD [EC:1.1.1.64]
synonym: "17beta-hydroxysteroid:NADP+ 17-oxidoreductase activity" EXACT [EC:1.1.1.64]
synonym: "NADP-dependent testosterone-17beta-oxidoreductase activity" EXACT [EC:1.1.1.64]
synonym: "testosterone 17beta-dehydrogenase (NADP+)" EXACT [EC:1.1.1.64]
xref: EC:1.1.1.64
xref: KEGG:R01838
xref: MetaCyc:1.1.1.64-RXN
xref: RHEA:14984
xref: Wikipedia:Testosterone_17beta-dehydrogenase_(NADP+)
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047046
name: homoisocitrate dehydrogenase activity
namespace: molecular_function
alt_id: GO:0047984
def: "Catalysis of the reaction: NAD+ + 3-carboxy-2-hydroxyadipate = NADH + H+ + CO2 + 2-keto-adipate." [EC:1.1.1.155, EC:1.1.1.87, MetaCyc:1.1.1.87-RXN]
comment: Note that EC:1.1.1.155 was merged into EC:1.1.1.87 as they are identical.
synonym: "(-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD(+) oxidoreductase (decarboxylating) activity" EXACT [EC:1.1.1.87]
synonym: "(-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.87]
synonym: "(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.87]
synonym: "2-hydroxy-3-carboxyadipate dehydrogenase activity" EXACT [EC:1.1.1.87]
synonym: "3-carboxy-2-hydroxyadipate dehydrogenase activity" EXACT []
synonym: "3-carboxy-2-hydroxyadipate:NAD(+) oxidoreductase (decarboxylating) activity" EXACT [EC:1.1.1.87]
synonym: "3-carboxy-2-hydroxyadipate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.87]
synonym: "homoisocitric dehydrogenase activity" EXACT [EC:1.1.1.87]
xref: EC:1.1.1.87
xref: MetaCyc:1.1.1.87-RXN
xref: RHEA:11903
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047047
name: oxaloglycolate reductase (decarboxylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: glycerate + CO2 + NAD(P)+ = NAD(P)H + H+ + 2-hydroxy-3-oxosuccinate." [EC:1.1.1.92, MetaCyc:1.1.1.92-RXN]
synonym: "D-glycerate:NAD(P)+ oxidoreductase (carboxylating)" EXACT [EC:1.1.1.92]
xref: EC:1.1.1.92
xref: MetaCyc:1.1.1.92-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047048
name: 3-hydroxybenzyl-alcohol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxybenzyl alcohol + NADP(+) = 3-hydroxybenzaldehyde + H(+) + NADPH." [EC:1.1.1.97, RHEA:22343]
synonym: "3-hydroxybenzyl-alcohol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.97]
synonym: "m-hydroxybenzyl alcohol (NADP) dehydrogenase activity" EXACT [EC:1.1.1.97]
synonym: "m-hydroxybenzyl alcohol dehydrogenase activity" EXACT [EC:1.1.1.97]
synonym: "m-hydroxybenzylalcohol dehydrogenase activity" EXACT [EC:1.1.1.97]
xref: EC:1.1.1.97
xref: KEGG:R04136
xref: MetaCyc:1.1.1.97-RXN
xref: RHEA:22343
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047049
name: (R)-2-hydroxy-fatty acid dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-2-hydroxystearate + NAD(+) = 2-oxostearate + H(+) + NADH." [EC:1.1.1.98, RHEA:15952]
synonym: "(R)-2-hydroxy-fatty-acid dehydrogenase activity" EXACT []
synonym: "(R)-2-hydroxystearate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.98]
synonym: "2-hydroxy fatty acid oxidase" BROAD [EC:1.1.1.98]
synonym: "D-2-hydroxy fatty acid dehydrogenase activity" EXACT [EC:1.1.1.98]
xref: EC:1.1.1.98
xref: KEGG:R03021
xref: MetaCyc:1.1.1.98-RXN
xref: RHEA:15952
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047050
name: (S)-2-hydroxy-fatty acid dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-2-hydroxystearate + NAD(+) = 2-oxostearate + H(+) + NADH." [EC:1.1.1.99, RHEA:11387]
synonym: "(S)-2-hydroxy-fatty-acid dehydrogenase activity" EXACT []
synonym: "(S)-2-hydroxystearate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.99]
synonym: "2-hydroxy fatty acid oxidase" BROAD [EC:1.1.1.99]
synonym: "dehydrogenase, L-2-hydroxy fatty acid" EXACT [EC:1.1.1.99]
synonym: "L-2-hydroxy fatty acid dehydrogenase activity" EXACT [EC:1.1.1.99]
xref: EC:1.1.1.99
xref: KEGG:R03022
xref: MetaCyc:1.1.1.99-RXN
xref: RHEA:11387
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047051
name: D-lactate dehydrogenase (cytochrome c-553) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 ferricytochrome C-553 + D-lactate = 2 ferrocytochrome C-553 + pyruvate." [EC:1.1.2.5, MetaCyc:1.1.2.5-RXN]
synonym: "(R)-lactate:ferricytochrome-c-553 2-oxidoreductase activity" EXACT [EC:1.1.2.5]
xref: EC:1.1.2.5
xref: MetaCyc:1.1.2.5-RXN
is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor

[Term]
id: GO:0047052
name: (S)-stylopine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-cheilanthifoline + H(+) + NADPH + O(2) = (S)-stylopine + 2 H(2)O + NADP(+)." [EC:1.14.21.1, RHEA:13776]
synonym: "(S)-cheilanthifoline oxidase (methylenedioxy-bridge-forming) activity" EXACT [EC:1.14.21.1]
synonym: "(S)-cheilanthifoline,NADPH:oxygen oxidoreductase (methylenedioxy-bridge-forming)" EXACT [EC:1.14.21.1]
xref: EC:1.14.21.1
xref: KEGG:R04690
xref: MetaCyc:1.1.3.32-RXN
xref: RHEA:13776
is_a: GO:0046996 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NAD(P)H as one donor, and the other dehydrogenated

[Term]
id: GO:0047053
name: (S)-cheilanthifoline synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-scoulerine + H(+) + NADPH + O(2) = (S)-cheilanthifoline + 2 H(2)O + NADP(+)." [EC:1.14.21.2, RHEA:20488]
synonym: "(S)-scoulerine oxidase (methylenedioxy-bridge-forming) activity" EXACT []
synonym: "(S)-scoulerine,NADPH:oxygen oxidoreductase (methylenedioxy-bridge-forming)" EXACT [EC:1.14.21.2]
xref: EC:1.14.21.2
xref: KEGG:R03834
xref: MetaCyc:1.14.21.2-RXN
xref: RHEA:20488
is_a: GO:0046996 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NAD(P)H as one donor, and the other dehydrogenated

[Term]
id: GO:0047054
name: berbamunine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + NADPH + H+ + R-N-methylcoclaurine + S-N-methylcoclaurine = 2 H2O + NADP+ + berbamunine." [EC:1.14.21.3, MetaCyc:1.1.3.34-RXN]
synonym: "(S)-N-methylcoclaurine oxidase (C-O phenol-coupling) activity" EXACT [EC:1.14.21.3]
synonym: "(S)-N-methylcoclaurine,NADPH:oxygen oxidoreductase (C-O phenol-coupling)" EXACT [EC:1.14.21.3]
xref: EC:1.14.21.3
xref: MetaCyc:1.1.3.34-RXN
xref: RHEA:23579
is_a: GO:0046996 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NAD(P)H as one donor, and the other dehydrogenated

[Term]
id: GO:0047055
name: salutaridine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-reticuline + H(+) + NADPH + O(2) = 2 H(2)O + NADP(+) + salutaridine." [EC:1.14.21.4, RHEA:17716]
synonym: "(R)-reticuline oxidase (C-C phenol-coupling) activity" EXACT [EC:1.14.21.4]
synonym: "(R)-reticuline,NADPH:oxygen oxidoreductase (C-C phenol-coupling)" EXACT [EC:1.14.21.4]
xref: EC:1.14.21.4
xref: KEGG:R04696
xref: MetaCyc:1.1.3.35-RXN
xref: RHEA:17716
is_a: GO:0046996 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NAD(P)H as one donor, and the other dehydrogenated

[Term]
id: GO:0047056
name: (S)-canadine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-tetrahydrocolumbamine + H(+) + NADPH + O(2) = (S)-canadine + 2 H(2)O + NADP(+)." [EC:1.14.21.5, RHEA:21459]
synonym: "(S)-tetrahydroberberine synthase activity" EXACT [EC:1.14.21.5]
synonym: "(S)-tetrahydrocolumbamine oxidase (methylenedioxy-bridge-forming) activity" EXACT [EC:1.14.21.5]
synonym: "(S)-tetrahydrocolumbamine,NADPH:oxygen oxidoreductase (methylenedioxy-bridge-forming)" EXACT [EC:1.14.21.5]
xref: EC:1.14.21.5
xref: KEGG:R04400
xref: MetaCyc:1.1.3.36-RXN
xref: RHEA:21459
is_a: GO:0046996 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NAD(P)H as one donor, and the other dehydrogenated

[Term]
id: GO:0047057
name: vitamin-K-epoxide reductase (warfarin-sensitive) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol." [EC:1.1.4.1, MetaCyc:1.1.4.1-RXN]
synonym: "2-methyl-3-phytyl-1,4-naphthoquinone:oxidized-dithiothreitol oxidoreductase activity" EXACT [EC:1.1.4.1]
synonym: "phylloquinone epoxide reductase activity" EXACT [EC:1.1.4.1]
synonym: "vitamin K1 epoxide reductase activity" NARROW [EC:1.1.4.1]
xref: EC:1.1.4.1
xref: MetaCyc:1.1.4.1-RXN
xref: Reactome:REACT_103833 "vitamin K epoxide -> vitamin K hydroquinone, Bos taurus"
xref: Reactome:REACT_106636 "vitamin K epoxide -> vitamin K hydroquinone, Sus scrofa"
xref: Reactome:REACT_113699 "vitamin K epoxide -> vitamin K hydroquinone, Drosophila melanogaster"
xref: Reactome:REACT_28305 "vitamin K epoxide -> vitamin K hydroquinone, Canis familiaris"
xref: Reactome:REACT_31765 "vitamin K epoxide -> vitamin K hydroquinone, Mus musculus"
xref: Reactome:REACT_91480 "vitamin K epoxide -> vitamin K hydroquinone, Danio rerio"
xref: Reactome:REACT_950 "vitamin K epoxide -> vitamin K hydroquinone, Homo sapiens"
xref: RHEA:13820
is_a: GO:0016900 ! oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor

[Term]
id: GO:0047058
name: vitamin-K-epoxide reductase (warfarin-insensitive) activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol." [EC:1.1.4.2, MetaCyc:1.1.4.2-RXN]
synonym: "3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone:oxidized-dithiothreitol oxidoreductase activity" EXACT [EC:1.1.4.2]
synonym: "vitamin K 2,3-epoxide reductase activity" EXACT [EC:1.1.4.2]
xref: EC:1.1.4.2
xref: MetaCyc:1.1.4.2-RXN
xref: RHEA:21563
is_a: GO:0016900 ! oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor

[Term]
id: GO:0047059
name: polyvinyl alcohol dehydrogenase (cytochrome) activity
namespace: molecular_function
def: "Catalysis of the reaction: polyvinyl alcohol + ferricytochrome c = oxidized polyvinyl alcohol + ferrocytochrome c + H+." [EC:1.1.2.6]
subset: gosubset_prok
synonym: "polyvinyl alcohol:ferricytochrome-c oxidoreductase activity" EXACT systematic_synonym [EC:1.1.2.6]
synonym: "polyvinyl-alcohol:(acceptor) oxidoreductase activity" BROAD [EC:1.1.99.23]
synonym: "polyvinyl-alcohol:acceptor oxidoreductase activity" BROAD [EC:1.1.99.23]
synonym: "PVA dehydrogenase activity" BROAD [EC:1.1.99.23]
xref: EC:1.1.2.6
xref: KEGG:R03136
xref: MetaCyc:RXN-11316
is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor

[Term]
id: GO:0047060
name: (R)-pantolactone dehydrogenase (flavin) activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-pantolactone + A = 2-dehydropantolactone + AH(2)." [EC:1.1.99.27, RHEA:21007]
synonym: "(R)-pantolactone:acceptor oxidoreductase (flavin-containing)" EXACT [EC:1.1.99.27]
synonym: "(R)-pantoyllactone dehydrogenase (flavin) activity" EXACT [EC:1.1.99.27]
synonym: "2-dehydropantolactone reductase (flavin) activity" EXACT [EC:1.1.99.27]
synonym: "2-dehydropantoyl-lactone reductase (flavin) activity" EXACT [EC:1.1.99.27]
xref: EC:1.1.99.27
xref: KEGG:R03156
xref: MetaCyc:1.1.99.27-RXN
xref: RHEA:21007
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0047061
name: glucose-fructose oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-fructose + D-glucose = D-glucitol + D-glucono-1,5-lactone." [EC:1.1.99.28, RHEA:20640]
subset: gosubset_prok
synonym: "D-glucose:D-fructose oxidoreductase activity" EXACT [EC:1.1.99.28]
xref: EC:1.1.99.28
xref: KEGG:R00874
xref: MetaCyc:1.1.99.28-RXN
xref: RHEA:20640
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0047062
name: trans-acenaphthene-1,2-diol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (+-)-trans-acenaphthene-1,2-diol + 2 NADP(+) = acenaphthene-1,2-dione + 2 H(+) + 2 NADPH." [EC:1.10.1.1, RHEA:22187]
synonym: "(+-)-trans-acenaphthene-1,2-diol:NADP+ oxidoreductase activity" EXACT [EC:1.10.1.1]
synonym: "trans-1,2-acenaphthenediol dehydrogenase activity" EXACT [EC:1.10.1.1]
xref: EC:1.10.1.1
xref: KEGG:R04059
xref: MetaCyc:1.10.1.1-RXN
xref: RHEA:22187
is_a: GO:0016680 ! oxidoreductase activity, acting on diphenols and related substances as donors, NAD or NADP as acceptor

[Term]
id: GO:0047063
name: L-ascorbate-cytochrome-b5 reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: ferricytochrome B5 + ascorbate = ferrocytochrome B5 + monodehydroascorbate." [EC:1.10.2.1, MetaCyc:1.10.2.1-RXN]
synonym: "ascorbate-cytochrome b5 reductase activity" EXACT [EC:1.10.2.1]
synonym: "L-ascorbate:ferricytochrome-b5 oxidoreductase activity" EXACT [EC:1.10.2.1]
xref: EC:1.10.2.1
xref: MetaCyc:1.10.2.1-RXN
is_a: GO:0016681 ! oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor

[Term]
id: GO:0047064
name: sulochrin oxidase [(+)-bisdechlorogeodin-forming] activity
namespace: molecular_function
def: "Catalysis of the reaction: O(2) + 2 sulochrin = 2 (2S)-bisdechlorogeodin + 2 H(2)O." [EC:1.21.3.4, RHEA:24095]
synonym: "sulochrin oxidase activity" EXACT [EC:1.21.3.4]
synonym: "sulochrin:oxygen oxidoreductase (cyclizing, (+)-specific)" EXACT [EC:1.21.3.4]
xref: EC:1.21.3.4
xref: KEGG:R00060
xref: MetaCyc:1.10.3.7-RXN
xref: RHEA:24095
is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor

[Term]
id: GO:0047065
name: sulochrin oxidase [(-)-bisdechlorogeodin-forming] activity
namespace: molecular_function
def: "Catalysis of the reaction: O(2) + 2 sulochrin = 2 (2R)-bisdechlorogeodin + 2 H(2)O." [EC:1.21.3.5, RHEA:22619]
synonym: "sulochrin oxidase activity" BROAD [EC:1.21.3.5]
synonym: "sulochrin:oxygen oxidoreductase (cyclizing, (-)-specific)" EXACT [EC:1.21.3.5]
xref: EC:1.21.3.5
xref: KEGG:R00061
xref: MetaCyc:1.10.3.8-RXN
xref: RHEA:22619
is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor

[Term]
id: GO:0047066
name: phospholipid-hydroperoxide glutathione peroxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a lipid hydroperoxide + 2 reduced glutathione = 2 H2O + lipid + 2 oxidized glutathione." [EC:1.11.1.12, MetaCyc:1.11.1.12-RXN]
synonym: "glutathione:lipid-hydroperoxide oxidoreductase activity" EXACT [EC:1.11.1.12]
synonym: "hydroperoxide glutathione peroxidase activity" EXACT [EC:1.11.1.12]
synonym: "peroxidation-inhibiting protein activity" RELATED [EC:1.11.1.12]
synonym: "peroxidation-inhibiting protein: peroxidase, glutathione (phospholipid hydroperoxide-reducing)" EXACT [EC:1.11.1.12]
synonym: "PHGPX" RELATED [EC:1.11.1.12]
synonym: "phospholipid hydroperoxide glutathione peroxidase activity" EXACT [EC:1.11.1.12]
xref: EC:1.11.1.12
xref: MetaCyc:1.11.1.12-RXN
is_a: GO:0016684 ! oxidoreductase activity, acting on peroxide as acceptor

[Term]
id: GO:0047067
name: hydrogen:quinone oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2) + menaquinone = reduced menaquinone." [EC:1.12.5.1, RHEA:18644]
subset: gosubset_prok
synonym: "hydrogen-ubiquinone oxidoreductase activity" EXACT [EC:1.12.5.1]
synonym: "hydrogen:menaquinone oxidoreductase activity" EXACT [EC:1.12.5.1]
synonym: "membrane-bound hydrogenase activity" NARROW [EC:1.12.5.1]
synonym: "quinone-reactive Ni/Fe-hydrogenase activity" RELATED [EC:1.12.5.1]
xref: EC:1.12.5.1
xref: KEGG:R02965
xref: MetaCyc:1.12.5.1-RXN
xref: RHEA:18644
is_a: GO:0046994 ! oxidoreductase activity, acting on hydrogen as donor, with a quinone or similar compound as acceptor

[Term]
id: GO:0047068
name: N5,N10-methenyltetrahydromethanopterin hydrogenase activity
namespace: molecular_function
alt_id: GO:0016947
def: "Catalysis of the reaction: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H(2) = 5,10-methylenetetrahydromethanopterin + H(+)." [EC:1.12.98.2, RHEA:20020]
subset: gosubset_prok
synonym: "5,10-methenyltetrahydromethanopterin hydrogenase activity" EXACT [EC:1.12.98.2]
synonym: "H(2)-dependent methylene-H(4)MPT dehydrogenase activity" EXACT [EC:1.12.98.2]
synonym: "H(2)-forming N(5),N(10)-methylenetetrahydromethanopterin dehydrogenase activity" EXACT [EC:1.12.98.2]
synonym: "H2-dependent methylene-H4MPT dehydrogenase activity" EXACT [EC:1.12.98.2]
synonym: "H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase activity" EXACT [EC:1.12.98.2]
synonym: "hydrogen:5,10-methenyltetrahydromethanopterin oxidoreductase activity" EXACT [EC:1.12.98.2]
synonym: "hydrogen:N(5),N(10)-methenyltetrahydromethanopterin oxidoreductase activity" EXACT [EC:1.12.98.2]
synonym: "hydrogen:N5,N10-methenyltetrahydromethanopterin oxidoreductase activity" EXACT [EC:1.12.98.2]
synonym: "N(5),N(10)-methenyltetrahydromethanopterin hydrogenase activity" EXACT [EC:1.12.98.2]
synonym: "N5,N10-methylenetetrahydromethanopterin dehydrogenase activity" EXACT []
synonym: "nonmetal hydrogenase activity" RELATED [EC:1.12.98.2]
xref: EC:1.12.98.2
xref: KEGG:R04455
xref: MetaCyc:H2-METHYLENE-THMPT-DEHYDRO-RXN
xref: RHEA:20020
is_a: GO:0046995 ! oxidoreductase activity, acting on hydrogen as donor, with other known acceptors

[Term]
id: GO:0047069
name: 7,8-dihydroxykynurenate 8,8a-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7,8-dihydroxykynurenate + O(2) = 5-(3-carboxylato-3-oxoprop-1-en-1-yl)-4,6-dihydroxypyridine-2-carboxylate + H(+)." [EC:1.13.11.10, RHEA:23403]
synonym: "7,8-dihydroxykynurenate 8,8alpha-dioxygenase activity" EXACT [EC:1.13.11.10]
synonym: "7,8-dihydroxykynurenate oxygenase activity" EXACT [EC:1.13.11.10]
synonym: "7,8-dihydroxykynurenate:oxygen 8,8a-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.10]
synonym: "7,8-dihydroxykynurenate:oxygen 8,8alpha-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.10]
xref: EC:1.13.11.10
xref: KEGG:R03253
xref: MetaCyc:1.13.11.10-RXN
xref: RHEA:23403
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0047070
name: 3-carboxyethylcatechol 2,3-dioxygenase activity
namespace: molecular_function
alt_id: GO:0008669
def: "Catalysis of the reaction: O2 + 3-(2,3-dihydroxyphenyl)propanoate = 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate." [EC:1.13.11.16, MetaCyc:1.13.11.16-RXN]
synonym: "2,3-dihydroxy-beta-phenylpropionate oxygenase activity" EXACT [EC:1.13.11.16]
synonym: "2,3-dihydroxy-beta-phenylpropionic dioxygenase activity" EXACT [EC:1.13.11.16]
synonym: "3-(2,3-dihydroxyphenyl)propanoate:oxygen 1,2-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.16]
synonym: "3-(2,3-dihydroxyphenyl)propanoate:oxygen 1,2-oxidoreductase activity" EXACT [EC:1.13.11.16]
xref: EC:1.13.11.16
xref: MetaCyc:1.13.11.16-RXN
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0047071
name: 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O(2) = 3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H(+)." [EC:1.13.11.25, RHEA:21355]
synonym: "3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione:oxygen 4,5-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.25]
synonym: "3-alkylcatechol 2,3-dioxygenase activity" EXACT [EC:1.13.11.25]
synonym: "steroid 4,5-dioxygenase activity" BROAD [EC:1.13.11.25]
xref: EC:1.13.11.25
xref: KEGG:R04597
xref: MetaCyc:1.13.11.25-RXN
xref: RHEA:21355
xref: UM-BBD_reactionID:r1151
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0047072
name: 2,3-dihydroxybenzoate 2,3-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-dihydroxybenzoate + O(2) = 2-carboxy-cis,cis-muconate + 2 H(+)." [EC:1.13.11.28, RHEA:15372]
synonym: "2,3-dihydroxybenzoate 2,3-oxygenase activity" EXACT [EC:1.13.11.28]
synonym: "2,3-dihydroxybenzoate:oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.28]
xref: EC:1.13.11.28
xref: KEGG:R01506
xref: MetaCyc:1.13.11.28-RXN
xref: RHEA:15372
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0047073
name: 2,4'-dihydroxyacetophenone dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4'-dihydroxyacetophenone + O(2) = 4-hydroxybenzoate + formate + 2 H(+)." [EC:1.13.11.41, RHEA:24419]
subset: gosubset_prok
synonym: "(4-hydroxybenzoyl)methanol oxygenase activity" EXACT [EC:1.13.11.41]
synonym: "2,4'-dihydroxyacetophenone oxidoreductase (C-C-bond-cleaving)" EXACT [EC:1.13.11.41]
xref: EC:1.13.11.41
xref: KEGG:R01305
xref: MetaCyc:1.13.11.41-RXN
xref: RHEA:24419
xref: UM-BBD_reactionID:r1410
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0047074
name: 4-hydroxycatechol 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + benzene-1,2,4-triol = maleylacetate." [EC:1.13.11.-, MetaCyc:R308-RXN]
xref: EC:1.13.11.-
xref: MetaCyc:RXN-10137
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0047075
name: 2,5-dihydroxypyridine 5,6-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + O2 + 2,5-dihydroxypyridine = formate + maleamate." [EC:1.13.11.9, MetaCyc:1.13.11.9-RXN]
synonym: "2,5-dihydroxypyridine oxygenase activity" EXACT [EC:1.13.11.9]
synonym: "2,5-dihydroxypyridine:oxygen 5,6-oxidoreductase activity" EXACT [EC:1.13.11.9]
synonym: "pyridine-2,5-diol dioxygenase activity" EXACT [EC:1.13.11.9]
xref: EC:1.13.11.9
xref: MetaCyc:1.13.11.9-RXN
xref: RHEA:27525
xref: UM-BBD_reactionID:r1443
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0047077
name: Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + ATP + Photinus luciferin = light + diphosphate + AMP + CO2 + oxidized Photinus luciferin." [EC:1.13.12.7, MetaCyc:1.13.12.7-RXN]
synonym: "firefly luciferase activity" EXACT [EC:1.13.12.7]
synonym: "firefly luciferin luciferase activity" EXACT [EC:1.13.12.7]
synonym: "luciferase (firefly luciferin)" EXACT [EC:1.13.12.7]
synonym: "luciferase activity" BROAD [EC:1.13.12.7]
synonym: "Photinus luciferin 4-monooxygenase (adenosine triphosphate-hydrolyzing)" EXACT [EC:1.13.12.7]
synonym: "Photinus pyralis luciferase activity" EXACT [EC:1.13.12.7]
synonym: "Photinus-luciferin 4-monooxygenase (ATP-hydrolysing)" EXACT [EC:1.13.12.7]
synonym: "Photinus-luciferin:oxygen 4-oxidoreductase (decarboxylating, ATP-hydrolysing)" EXACT [EC:1.13.12.7]
xref: EC:1.13.12.7
xref: MetaCyc:1.13.12.7-RXN
xref: RHEA:10735
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)
is_a: GO:0045289 ! luciferin monooxygenase activity

[Term]
id: GO:0047078
name: 3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + 3-hydroxy-1H-quinolin-4-one = carbon monoxide + N-formylanthranilate." [EC:1.13.11.47, MetaCyc:1.13.11.47-RXN]
subset: gosubset_prok
synonym: "(1H)-3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity" EXACT [EC:1.13.11.47]
synonym: "1H-3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity" EXACT []
synonym: "3-hydroxy-1H-quinolin-4-one 2,4-dioxygenase (CO-forming)" EXACT [EC:1.13.11.47]
synonym: "3-hydroxy-4(1H)-one, 2,4-dioxygenase activity" EXACT [EC:1.13.11.47]
synonym: "3-hydroxy-4-oxo-1,4-dihydroquinoline 2,4-dioxygenase activity" EXACT [EC:1.13.11.47]
synonym: "quinoline-3,4-diol 2,4-dioxygenase activity" EXACT [EC:1.13.11.47]
xref: EC:1.13.11.47
xref: MetaCyc:1.13.11.47-RXN
xref: RHEA:17952
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0047079
name: deoxyuridine 1'-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2'-deoxyuridine + 2-oxoglutarate + O(2) = 2-deoxy-D-ribono-1,4-lactone + CO(2) + succinate + uracil." [EC:1.14.11.10, RHEA:23319]
synonym: "2'-deoxyuridine,2-oxoglutarate:oxygen oxidoreductase (1'-hydroxylating)" EXACT [EC:1.14.11.10]
synonym: "pyrimidine-deoxynucleoside 1'-dioxygenase activity" BROAD [EC:1.14.11.10]
synonym: "pyrimidine-deoxynucleoside,2-oxoglutarate 1'-dioxygenase activity" BROAD [EC:1.14.11.10]
xref: EC:1.14.11.10
xref: KEGG:R02486
xref: MetaCyc:1.14.11.10-RXN
xref: RHEA:23319
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0047080
name: deoxyuridine 2'-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2'-deoxyuridine + 2-oxoglutarate + O(2) = CO(2) + succinate + uridine." [EC:1.14.11.3, RHEA:21079]
synonym: "2'-deoxyuridine,2-oxoglutarate:oxygen oxidoreductase (2'-hydroxylating)" EXACT [EC:1.14.11.3]
synonym: "deoxyuridine 2'-hydroxylase activity" EXACT [EC:1.14.11.3]
synonym: "pyrimidine deoxyribonucleoside 2'-hydroxylase activity" BROAD [EC:1.14.11.3]
synonym: "pyrimidine-deoxynucleoside 2'-dioxygenase activity" BROAD [EC:1.14.11.3]
synonym: "pyrimidine-deoxynucleoside,2-oxoglutarate 2'-dioxygenase activity" BROAD [EC:1.14.11.3]
synonym: "thymidine 2'-dioxygenase activity" NARROW [EC:1.14.11.3]
synonym: "thymidine 2'-hydroxylase activity" RELATED [EC:1.14.11.3]
synonym: "thymidine 2-oxoglutarate dioxygenase activity" RELATED [EC:1.14.11.3]
synonym: "thymidine dioxygenase activity" RELATED [EC:1.14.11.3]
xref: EC:1.14.11.3
xref: KEGG:R01879
xref: MetaCyc:1.14.11.3-RXN
xref: RHEA:21079
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0047081
name: 3-hydroxy-2-methylpyridinecarboxylate dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + NAD(P)H + H+ + 3-hydroxy-2-methylpyridine-5-carboxylate = NAD(P)+ + 2-(acetamidomethylene)succinate." [EC:1.14.12.4, MetaCyc:1.14.12.4-RXN]
synonym: "2-methyl-3-hydroxypyridine 5-carboxylic acid dioxygenase activity" EXACT [EC:1.14.12.4]
synonym: "3-hydroxy-2-methylpyridine-5-carboxylate,NAD(P)H:oxygen oxidoreductase (decyclizing)" EXACT [EC:1.14.12.4]
synonym: "3-hydroxy-3-methylpyridinecarboxylate dioxygenase activity" EXACT [EC:1.14.12.4]
synonym: "methylhydroxypyridine carboxylate dioxygenase activity" EXACT [EC:1.14.12.4]
synonym: "methylhydroxypyridinecarboxylate oxidase activity" EXACT [EC:1.14.12.4]
xref: EC:1.14.12.4
xref: MetaCyc:1.14.12.4-RXN
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0047082
name: 3,9-dihydroxypterocarpan 6a-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (6aR,11aR)-3,9-dihydroxypterocarpan + H(+) + NADPH + O(2) = (6aS,11aS)-3,6a,9-trihydroxypterocarpan + H(2)O + NADP(+). (6aS,11aS)-3,6a,9-trihydroxypterocarpan is also known as (-)-glycinol." [EC:1.14.13.28, RHEA:15324]
synonym: "(6aR,11aR)-3,9-dihydroxypterocarpan,NADPH:oxygen oxidoreductase (6a-hydroxylating)" EXACT [EC:1.14.13.28]
synonym: "3,9-dihydroxypterocarpan 6a-hydroxylase activity" EXACT []
synonym: "3,9-dihydroxypterocarpan 6alpha-monooxygenase (erroneous)" EXACT [EC:1.14.13.28]
xref: EC:1.14.13.28
xref: KEGG:R03452
xref: MetaCyc:RXN-4505
xref: RHEA:15324
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047083
name: 5-O-(4-coumaroyl)-D-quinate 3'-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + NADPH + H+ + trans-5-O-(4-coumaroyl)-D-quinate = H2O + NADP+ + trans-5-O-caffeoyl-D-quinate." [EC:1.14.13.36, MetaCyc:1.14.13.36-RXN]
synonym: "5-O-(4-coumaroyl)-D-quinate/shikimate 3'-hydroxylase activity" EXACT []
synonym: "coumaroylquinate(coumaroylshikimate) 3'-monooxygenase activity" EXACT [EC:1.14.13.36]
synonym: "trans-5-O-(4-coumaroyl)-D-quinate,NADPH:oxygen oxidoreductase (3'-hydroxylating)" EXACT [EC:1.14.13.36]
xref: EC:1.14.13.36
xref: MetaCyc:1.14.13.36-RXN
xref: RHEA:16268
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047084
name: methyltetrahydroprotoberberine 14-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + NADPH + H+ + (S)-N-methylcanadine = H2O + NADP+ + allocryptopine." [EC:1.14.13.37, MetaCyc:1.14.13.37-RXN]
synonym: "(S)-cis-N-methyltetrahydroberberine 14-monooxygenase activity" EXACT [EC:1.14.13.37]
synonym: "(S)-cis-N-methyltetrahydroprotoberberine-14-hydroxylase activity" EXACT [EC:1.14.13.37]
synonym: "(S)-N-methylcanadine,NADPH:oxygen oxidoreductase (14-hydroxylating)" EXACT [EC:1.14.13.37]
synonym: "methyltetrahydroprotoberberine 14-hydroxylase activity" EXACT []
xref: EC:1.14.13.37
xref: MetaCyc:1.14.13.37-RXN
xref: RHEA:23687
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047085
name: hydroxyphenylacetonitrile 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxyphenylacetonitrile + H(+) + NADPH + O(2) = 4-hydroxymandelonitrile + H(2)O + NADP(+)." [RHEA:23743]
synonym: "4-hydroxyphenylacetonitrile hydroxylase activity" EXACT [EC:1.14.13.42]
synonym: "4-hydroxyphenylacetonitrile monooxygenase activity" EXACT []
synonym: "4-hydroxyphenylacetonitrile,NADPH:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.13.42]
xref: EC:1.14.13.68
xref: KEGG:R02708
xref: MetaCyc:1.14.13.42-RXN
xref: RHEA:23743
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047086
name: ketosteroid monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + NADPH + progesterone = H2O + NADP+ + testosterone acetate." [EC:1.14.13.54, MetaCyc:1.14.13.54-RXN]
synonym: "17alpha-hydroxyprogesterone, NADPH2:oxygen oxidoreductase (20-hydroxylating, side-chain cleaving)" EXACT [EC:1.14.13.54]
synonym: "androstenedione, NADPH2:oxygen oxidoreductase (17-hydroxylating, lactonizing)" EXACT [EC:1.14.13.54]
synonym: "ketosteroid,NADPH:oxygen oxidoreductase (20-hydroxylating, ester-producing/20-hydroxylating, side-chain cleaving/17-hydroxylating, lactonizing)" EXACT [EC:1.14.13.54]
synonym: "progesterone, NADPH2:oxygen oxidoreductase (20-hydroxylating, ester-producing)" EXACT [EC:1.14.13.54]
synonym: "steroid-ketone monooxygenase activity" EXACT [EC:1.14.13.54]
xref: EC:1.14.13.54
xref: MetaCyc:1.14.13.54-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047087
name: protopine 6-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(+) + NADPH + O(2) + protopine = 6-hydroxyprotopine + H(2)O + NADP(+)." [EC:1.14.13.55, RHEA:22647]
synonym: "protopine 6-hydroxylase activity" EXACT []
synonym: "protopine,NADPH:oxygen oxidoreductase (6-hydroxylating)" EXACT [EC:1.14.13.55]
xref: EC:1.14.13.55
xref: KEGG:R04699
xref: MetaCyc:1.14.13.55-RXN
xref: RHEA:22647
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047088
name: dihydrosanguinarine 10-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: dihydrosanguinarine + H(+) + NADPH + O(2) = 10-hydroxydihydrosanguinarine + H(2)O + NADP(+)." [EC:1.14.13.56, RHEA:10531]
synonym: "dihydrosanguinarine 10-hydroxylase activity" EXACT []
synonym: "dihydrosanguinarine,NADPH:oxygen oxidoreductase (10-hydroxylating)" EXACT [EC:1.14.13.56]
xref: EC:1.14.13.56
xref: KEGG:R04702
xref: MetaCyc:1.14.13.56-RXN
xref: RHEA:10531
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047089
name: dihydrochelirubine 12-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: dihydrochelirubine + H(+) + NADPH + O(2) = 12-hydroxydihydrochelirubine + H(2)O + NADP(+)." [EC:1.14.13.57, RHEA:10159]
synonym: "dihydrochelirubine 12-hydroxylase activity" EXACT []
synonym: "dihydrochelirubine,NADPH:oxygen oxidoreductase (12-hydroxylating)" EXACT [EC:1.14.13.57]
xref: EC:1.14.13.57
xref: KEGG:R04708
xref: MetaCyc:1.14.13.57-RXN
xref: RHEA:10159
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047090
name: benzoyl-CoA 3-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzoyl-CoA + H(+) + NADPH + O(2) = 3-hydroxybenzoyl-CoA + H(2)O + NADP(+)." [EC:1.14.13.58, RHEA:23219]
synonym: "benzoyl-CoA 3-hydroxylase activity" EXACT []
synonym: "benzoyl-CoA,NADPH:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.58]
xref: EC:1.14.13.58
xref: KEGG:R02449
xref: MetaCyc:1.14.13.58-RXN
xref: RHEA:23219
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047091
name: L-lysine 6-monooxygenase (NADPH) activity
namespace: molecular_function
alt_id: GO:0008739
def: "Catalysis of the reaction: L-lysine + NADPH + O(2) = N(6)-hydroxy-L-lysine + H(2)O + NADP(+)." [EC:1.14.13.59, RHEA:23231]
comment: Note that EC:1.13.12.10 was merged into this term.
subset: gosubset_prok
synonym: "L-lysine 6-monooxygenase activity" EXACT []
synonym: "L-lysine,NADPH:oxygen oxidoreductase (6-hydroxylating)" EXACT [EC:1.14.13.59]
synonym: "lysine N(6)-hydroxylase activity" EXACT [EC:1.14.13.59]
synonym: "lysine N6-hydroxylase activity" EXACT []
xref: EC:1.14.13.59
xref: KEGG:R00448
xref: MetaCyc:1.14.13.59-RXN
xref: RHEA:23231
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047092
name: 27-hydroxycholesterol 7-alpha-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + NADPH + 27-hydroxycholesterol = H2O + NADP+ + 7-alpha,27-dihydroxycholesterol." [EC:1.14.13.60, MetaCyc:1.14.13.60-RXN]
synonym: "27-hydroxycholesterol 7-alpha-hydroxylase activity" EXACT [EC:1.14.13.60]
synonym: "27-hydroxycholesterol 7a-hydroxylase activity" EXACT []
synonym: "27-hydroxycholesterol 7alpha-hydroxylase activity" EXACT [EC:1.14.13.60]
synonym: "27-hydroxycholesterol 7alpha-monooxygenase activity" EXACT [EC:1.14.13.60]
synonym: "27-hydroxycholesterol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)" EXACT [EC:1.14.13.60]
xref: EC:1.14.13.60
xref: MetaCyc:1.14.13.60-RXN
xref: RHEA:19044
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047093
name: 4-hydroxyquinoline 3-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(+) + NADH + O(2) + quinolin-4-ol = H(2)O + NAD(+) + quinoline-3,4-diol." [EC:1.14.13.62, RHEA:19328]
synonym: "1-H-4-oxoquinoline 3-monooxygenase activity" EXACT [EC:1.14.13.62]
synonym: "quinolin-4(1H)-one 3-monooxygenase activity" EXACT [EC:1.14.13.62]
synonym: "quinolin-4(1H)-one,NADH:oxygen oxidoreductase (3-oxygenating)" EXACT [EC:1.14.13.62]
xref: EC:1.14.13.62
xref: KEGG:R05154
xref: MetaCyc:1.14.13.62-RXN
xref: RHEA:19328
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047094
name: 3-hydroxyphenylacetate 6-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + NAD(P)H + 3-hydroxyphenylacetate = H2O + NAD(P)+ + homogentisate." [EC:1.14.13.63, MetaCyc:1.14.13.63-RXN]
synonym: "3-hydroxyphenylacetate 6-monooxygenase activity" EXACT [EC:1.14.13.63]
synonym: "3-hydroxyphenylacetate,NAD(P)H:oxygen oxidoreductase (6-hydroxylating)" EXACT [EC:1.14.13.63]
xref: EC:1.14.13.63
xref: MetaCyc:1.14.13.63-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047095
name: 2-hydroxycyclohexanone 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxycyclohexan-1-one + NADPH + O(2) = 6-oxohexanoate + H(2)O + NADP(+)." [EC:1.14.13.66, RHEA:25172]
synonym: "2-hydroxycyclohexan-1-one,NADPH:oxygen 2-oxidoreductase (1,2-lactonizing)" EXACT [EC:1.14.13.66]
xref: EC:1.14.13.66
xref: KEGG:R03281
xref: MetaCyc:1.14.13.66-RXN
xref: RHEA:25172
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047096
name: androst-4-ene-3,17-dione monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: AH(2) + androst-4-ene-3,17-dione + O(2) = A + H(2)O + testololactone." [EC:1.14.99.12, RHEA:22699]
synonym: "4-androstene-3,17-dione monooxygenase activity" EXACT []
synonym: "androst-4-ene-3,17-dione 17-oxidoreductase activity" EXACT [EC:1.14.99.12]
synonym: "androst-4-ene-3,17-dione hydroxylase activity" EXACT [EC:1.14.99.12]
synonym: "androst-4-ene-3,17-dione-hydrogen-donor:oxygen oxidoreductase (13-hydroxylating, lactonizing)" EXACT [EC:1.14.99.12]
synonym: "androstene-3,17-dione hydroxylase activity" EXACT []
synonym: "androstenedione monooxygenase activity" EXACT [EC:1.14.99.12]
xref: EC:1.14.99.12
xref: KEGG:R01833
xref: MetaCyc:1.14.99.12-RXN
xref: RHEA:22699
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0047097
name: phylloquinone monooxygenase (2,3-epoxidizing) activity
namespace: molecular_function
def: "Catalysis of the reaction: AH(2) + O(2) + phylloquinone = 2,3-epoxyphylloquinone + A + H(2)O." [EC:1.14.99.20, RHEA:16748]
synonym: "phylloquinone epoxidase activity" EXACT [EC:1.14.99.20]
synonym: "phylloquinone,hydrogen-donor:oxygen oxidoreductase (2,3-epoxidizing)" EXACT [EC:1.14.99.20]
synonym: "vitamin K 2,3-epoxidase activity" EXACT [EC:1.14.99.20]
synonym: "vitamin K epoxidase activity" EXACT [EC:1.14.99.20]
synonym: "vitamin K1 epoxidase activity" EXACT [EC:1.14.99.20]
xref: EC:1.14.99.20
xref: KEGG:R03510
xref: MetaCyc:1.14.99.20-RXN
xref: RHEA:16748
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0047098
name: Latia-luciferin monooxygenase (demethylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 O2 + donor-H2 + Latia luciferin = light + H2O + acceptor + formate + CO2 + oxidized Latia luciferin." [EC:1.14.99.21, MetaCyc:1.14.99.21-RXN]
synonym: "Latia luciferin monooxygenase (demethylating)" EXACT [EC:1.14.99.21]
synonym: "Latia-luciferin,hydrogen-donor:oxygen oxidoreductase (demethylating)" EXACT [EC:1.14.99.21]
synonym: "luciferase (Latia luciferin)" EXACT [EC:1.14.99.21]
xref: EC:1.14.99.21
xref: MetaCyc:1.14.99.21-RXN
xref: RHEA:12680
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
is_a: GO:0045289 ! luciferin monooxygenase activity

[Term]
id: GO:0047099
name: CDP-4-dehydro-6-deoxyglucose reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + NAD(P)+ + CDP-4-dehydro-3,6-dideoxy-D-glucose = NAD(P)H + CDP-4-dehydro-6-deoxy-D-glucose." [EC:1.17.1.1, MetaCyc:1.17.1.1-RXN]
synonym: "CDP-4-dehydro-3,6-dideoxy-D-glucose:NAD(P)+ 3-oxidoreductase activity" EXACT [EC:1.17.1.1]
synonym: "CDP-4-keto-6-deoxy-D-glucose-3-dehydrogenase system activity" EXACT [EC:1.17.1.1]
synonym: "CDP-4-keto-6-deoxyglucose reductase activity" EXACT [EC:1.17.1.1]
synonym: "CDP-4-keto-deoxy-glucose reductase activity" EXACT [EC:1.17.1.1]
synonym: "cytidine diphosphate 4-keto-6-deoxy-D-glucose-3-dehydrogenase activity" EXACT [EC:1.17.1.1]
synonym: "cytidine diphospho-4-keto-6-deoxy-D-glucose reductase activity" EXACT [EC:1.17.1.1]
synonym: "NAD(P)H:CDP-4-keto-6-deoxy-D-glucose oxidoreductase activity" EXACT [EC:1.17.1.1]
xref: EC:1.17.1.1
xref: MetaCyc:1.17.1.1-RXN
is_a: GO:0016726 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor

[Term]
id: GO:0047100
name: glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphate + NADP+ + glyceraldehyde-3-phosphate = NADPH + 3-phospho-D-glyceroyl-phosphate." [EC:1.2.1.13, MetaCyc:1.2.1.13-RXN]
synonym: "D-glyceraldehyde-3-phosphate:NADP+ oxidoreductase (phosphorylating)" EXACT [EC:1.2.1.13]
synonym: "dehydrogenase, glyceraldehyde phosphate (nicotinamide adenine dinucleotide phosphate) (phosphorylating)" EXACT [EC:1.2.1.13]
synonym: "glyceraldehyde phosphate dehydrogenase (nicotinamide adenine dinucleotide phosphate) (phosphorylating)" EXACT [EC:1.2.1.13]
synonym: "NADP-dependent glyceraldehyde phosphate dehydrogenase activity" EXACT [EC:1.2.1.13]
synonym: "NADP-dependent glyceraldehyde-3-phosphate dehydrogenase activity" EXACT [EC:1.2.1.13]
synonym: "NADP-triose phosphate dehydrogenase activity" EXACT [EC:1.2.1.13]
synonym: "triosephosphate dehydrogenase (NADP(+)) activity" EXACT [EC:1.2.1.13]
synonym: "triosephosphate dehydrogenase (NADP)" EXACT [EC:1.2.1.13]
synonym: "triosephosphate dehydrogenase (NADP+) activity" EXACT [EC:1.2.1.13]
xref: EC:1.2.1.13
xref: MetaCyc:1.2.1.13-RXN
xref: RHEA:10299
is_a: GO:0043891 ! glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity

[Term]
id: GO:0047101
name: 2-oxoisovalerate dehydrogenase (acylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + CoA + 2-keto-isovalerate = NADH + CO2 + isobutyryl-CoA." [EC:1.2.1.25, MetaCyc:1.2.1.25-RXN]
synonym: "2-oxoisovalerate dehydrogenase activity" EXACT [EC:1.2.1.25]
synonym: "3-methyl-2-oxobutanoate:NAD+ 2-oxidoreductase (CoA-methyl-propanoylating)" EXACT [EC:1.2.1.25]
xref: EC:1.2.1.25
xref: MetaCyc:1.2.1.25-RXN
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047102
name: aminomuconate-semialdehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + NAD+ + 2-aminomuconate semialdehyde = NADH + 2-amino-muconate." [EC:1.2.1.32, MetaCyc:1.2.1.32-RXN]
synonym: "2-aminomuconate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.32]
synonym: "2-aminomuconate-6-semialdehyde:NAD+ 6-oxidoreductase activity" EXACT [EC:1.2.1.32]
synonym: "2-hydroxymuconate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.32]
synonym: "2-hydroxymuconic acid semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.32]
synonym: "2-hydroxymuconic semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.32]
synonym: "alpha-aminomuconic epsilon-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.32]
synonym: "alpha-hydroxymuconic epsilon-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.32]
xref: EC:1.2.1.32
xref: MetaCyc:1.2.1.32-RXN
xref: Reactome:REACT_1425 "2-aminomuconate semialdehyde + NAD+ + H2O => aminomuconate + NADH + H+, Homo sapiens"
xref: Reactome:REACT_80 "2-aminomuconate semialdehyde + NAD+ + H2O => aminomuconate + NADH + H+, Felis catus"
xref: RHEA:14472
xref: UM-BBD_reactionID:r1434
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047103
name: 3-alpha,7-alpha,12-alpha-trihydroxycholestan-26-al 26-oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + NAD+ + 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-al = NADH + 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate." [EC:1.2.1.40, MetaCyc:1.2.1.40-RXN]
synonym: "3-alpha,7-alpha,12-alpha-trihydroxycholestan-26-al 26-dehydrogenase activity" EXACT [EC:1.2.1.40]
synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al dehydrogenase activity" EXACT [EC:1.2.1.40]
synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al:NAD+ 26-oxidoreductase activity" EXACT [EC:1.2.1.40]
synonym: "3alpha,7alpha,12alpha-trihydroxycholestan-26-al 26-dehydrogenase activity" EXACT [EC:1.2.1.40]
synonym: "3alpha,7alpha,12alpha-trihydroxycholestan-26-al 26-oxidoreductase activity" EXACT [EC:1.2.1.40]
synonym: "cholestanetriol-26-al 26-dehydrogenase activity" EXACT [EC:1.2.1.40]
synonym: "THAL-NAD oxidoreductase activity" EXACT [EC:1.2.1.40]
synonym: "trihydroxydeoxycoprostanal dehydrogenase activity" EXACT [EC:1.2.1.40]
xref: EC:1.2.1.40
xref: MetaCyc:1.2.1.40-RXN
xref: RHEA:24587
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047104
name: hexadecanal dehydrogenase (acylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: CoA + NAD(+) + palmitaldehyde = H(+) + NADH + palmitoyl-CoA." [EC:1.2.1.42, RHEA:19708]
synonym: "fatty acyl-CoA reductase activity" BROAD [EC:1.2.1.42]
synonym: "hexadecanal:NAD+ oxidoreductase (CoA-acylating)" EXACT [EC:1.2.1.42]
xref: EC:1.2.1.42
xref: KEGG:R01277
xref: MetaCyc:1.2.1.42-RXN
xref: RHEA:19708
xref: UM-BBD_reactionID:r1374
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047105
name: 4-trimethylammoniobutyraldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + 4-trimethylammoniobutanal = NADH + 4-trimethylammoniobutanoate." [EC:1.2.1.47, MetaCyc:1.2.1.47-RXN]
synonym: "4-N-trimethylaminobutyraldehyde dehydrogenase activity" EXACT [EC:1.2.1.47]
synonym: "4-trimethylaminobutyraldehyde dehydrogenase activity" EXACT [EC:1.2.1.47]
synonym: "4-trimethylammoniobutanal:NAD+ 1-oxidoreductase activity" EXACT [EC:1.2.1.47]
xref: EC:1.2.1.47
xref: MetaCyc:1.2.1.47-RXN
xref: RHEA:17988
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047106
name: 4-hydroxyphenylacetaldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + (4-hydroxyphenyl)acetaldehyde + H2O = NADH + 4-hydroxyphenylacetate." [EC:1.2.1.53, MetaCyc:1.2.1.53-RXN]
synonym: "4-HPAL dehydrogenase activity" EXACT [EC:1.2.1.53]
synonym: "4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.53]
xref: EC:1.2.1.53
xref: MetaCyc:1.2.1.53-RXN
xref: RHEA:17276
is_a: GO:0004029 ! aldehyde dehydrogenase (NAD) activity

[Term]
id: GO:0047107
name: gamma-guanidinobutyraldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-guanidinobutanal + H(2)O + NAD(+) = 4-guanidinobutanoate + 2 H(+) + NADH." [EC:1.2.1.54, RHEA:14384]
synonym: "4-guanidinobutanal:NAD+ 1-oxidoreductase activity" EXACT [EC:1.2.1.54]
synonym: "4-guanidinobutyraldehyde dehydrogenase activity" EXACT [EC:1.2.1.54]
synonym: "alpha-guanidinobutyraldehyde dehydrogenase activity" EXACT [EC:1.2.1.54]
synonym: "GBAL dehydrogenase activity" EXACT [EC:1.2.1.54]
xref: EC:1.2.1.54
xref: KEGG:R03177
xref: MetaCyc:1.2.1.54-RXN
xref: RHEA:14384
is_a: GO:0004029 ! aldehyde dehydrogenase (NAD) activity

[Term]
id: GO:0047108
name: (R)-3-hydroxyacid-ester dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: ethyl (R)-3-hydroxyhexanoate + NADP(+) = ethyl 3-oxohexanoate + H(+) + NADPH." [EC:1.1.1.279, RHEA:24355]
comment: Note that this term was EC:1.2.1.55.
synonym: "(R)-3-hydroxyacid ester dehydrogenase activity" EXACT []
synonym: "3-oxo ester (R)-reductase activity" EXACT [EC:1.1.1.279]
synonym: "ethyl-(R)-3-hydroxyhexanoate:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.279]
xref: EC:1.1.1.279
xref: KEGG:R04105
xref: MetaCyc:1.2.1.55-RXN
xref: RHEA:24355
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047109
name: (S)-3-hydroxyacid-ester dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: ethyl (S)-3-hydroxyhexanoate + NADP(+) = ethyl 3-oxohexanoate + H(+) + NADPH." [EC:1.1.1.280, RHEA:18272]
comment: Note that this term was EC:1.2.1.56.
synonym: "(S)-3-hydroxyacid ester dehydrogenase activity" EXACT []
synonym: "3-oxo ester (S)-reductase activity" EXACT [EC:1.1.1.280]
synonym: "ethyl-(S)-3-hydroxyhexanoate:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.280]
xref: EC:1.1.1.280
xref: KEGG:R04106
xref: MetaCyc:1.2.1.56-RXN
xref: RHEA:18272
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047110
name: phenylglyoxylate dehydrogenase (acylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: CoA + NAD(+) + phenylglyoxylate = benzoyl-CoA + CO(2) + NADH." [EC:1.2.1.58, RHEA:10375]
synonym: "phenylglyoxylate:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.58]
xref: EC:1.2.1.58
xref: KEGG:R02450
xref: MetaCyc:1.2.1.58-RXN
xref: RHEA:10375
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047111
name: formate dehydrogenase (cytochrome-c-553) activity
namespace: molecular_function
def: "Catalysis of the reaction: ferricytochrome C-553 + formate = ferrocytochrome C-553 + CO2." [EC:1.2.2.3, MetaCyc:1.2.2.3-RXN]
synonym: "formate dehydrogenase (cytochrome c-553)" EXACT [EC:1.2.2.3]
synonym: "formate:ferricytochrome-c-553 oxidoreductase activity" EXACT [EC:1.2.2.3]
xref: EC:1.2.2.3
xref: MetaCyc:1.2.2.3-RXN
is_a: GO:0016622 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor

[Term]
id: GO:0047112
name: pyruvate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(+) + O(2) + phosphate + pyruvate = acetyl phosphate + CO(2) + H(2)O(2)." [EC:1.2.3.3, RHEA:20851]
subset: gosubset_prok
synonym: "phosphate-dependent pyruvate oxidase activity" EXACT [EC:1.2.3.3]
synonym: "pyruvate:oxygen 2-oxidoreductase (phosphorylating)" EXACT [EC:1.2.3.3]
synonym: "pyruvic oxidase activity" EXACT [EC:1.2.3.3]
xref: EC:1.2.3.3
xref: KEGG:R00207
xref: MetaCyc:1.2.3.3-RXN
xref: RHEA:20851
is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor

[Term]
id: GO:0047113
name: aldehyde dehydrogenase (pyrroloquinoline-quinone) activity
namespace: molecular_function
def: "Catalysis of the reaction: an aldehyde + acceptor + H2O = a carboxylate + reduced acceptor." [EC:1.2.99.3, MetaCyc:1.2.99.3-RXN]
subset: gosubset_prok
synonym: "aldehyde dehydrogenase (acceptor) activity" EXACT [EC:1.2.99.3]
synonym: "aldehyde:(pyrroloquinoline-quinone) oxidoreductase activity" EXACT [EC:1.2.99.3]
xref: EC:1.2.99.3
xref: MetaCyc:1.2.99.3-RXN
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0047114
name: kynurenate-7,8-dihydrodiol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7,8-dihydro-7,8-dihydroxykynurenate + NAD(+) = 7,8-dihydroxykynurenate + H(+) + NADH." [EC:1.3.1.18, RHEA:22251]
synonym: "7,8-dihydro-7,8-dihydroxykynurenate dehydrogenase activity" EXACT [EC:1.3.1.18]
synonym: "7,8-dihydro-7,8-dihydroxykynurenate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.18]
synonym: "7,8-dihydroxykynurenic acid 7,8-diol dehydrogenase activity" EXACT [EC:1.3.1.18]
xref: EC:1.3.1.18
xref: KEGG:R03251
xref: MetaCyc:1.3.1.18-RXN
xref: RHEA:22251
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047115
name: trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + trans-1,2-dihydrobenzene-1,2-diol = NADPH + catechol." [EC:1.3.1.20, MetaCyc:1.3.1.20-RXN]
subset: gosubset_prok
synonym: "dihydrodiol dehydrogenase activity" EXACT [EC:1.3.1.20]
synonym: "trans-1,2-dihydrobenzene-1,2-diol:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.20]
xref: EC:1.3.1.20
xref: MetaCyc:1.3.1.20-RXN
xref: RHEA:16732
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047116
name: 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate = NADH + CO2 + catechol." [EC:1.3.1.25, MetaCyc:1.3.1.25-RXN]
synonym: "(1R,6R)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.3.1.25]
synonym: "2-hydro-1,2-dihydroxybenzoate dehydrogenase activity" EXACT [EC:1.3.1.25]
synonym: "3,5-cyclohexadiene-1,2-diol-1-carboxylate dehydrogenase activity" EXACT [EC:1.3.1.25]
synonym: "3,5-cyclohexadiene-1,2-diol-1-carboxylic acid dehydrogenase activity" EXACT [EC:1.3.1.25]
synonym: "cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate:NAD(+) oxidoreductase activity" EXACT [EC:1.3.1.25]
synonym: "cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.25]
synonym: "DHB dehydrogenase activity" EXACT [EC:1.3.1.25]
synonym: "DHBDH activity" EXACT [EC:1.3.1.25]
synonym: "dihydrodihydroxybenzoate dehydrogenase activity" EXACT [EC:1.3.1.25]
xref: EC:1.3.1.25
xref: MetaCyc:1.3.1.25-RXN
xref: RHEA:11563
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047117
name: enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + NADP+ = trans-D2-enoyl-[acyl-carrier protein] + NADPH + H+." [EC:1.3.1.39, MetaCyc:1.3.1.39-RXN]
synonym: "acyl-acyl-carrier-protein:NADP+ oxidoreductase (A-specific)" EXACT [EC:1.3.1.39]
synonym: "enoyl-[acyl-carrier protein] reductase (NADPH, A-specific) activity" EXACT []
synonym: "enoyl-ACP reductase (NADPH, A-specific) activity" EXACT []
synonym: "enoyl-ACp reductase activity" EXACT [EC:1.3.1.39]
synonym: "enoyl-acyl carrier protein (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.3.1.39]
synonym: "enoyl-acyl-carrier-protein reductase (NADPH, A-specific)" EXACT [EC:1.3.1.39]
xref: EC:1.3.1.39
xref: MetaCyc:1.3.1.39-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047118
name: 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,6-dioxo-6-phenylhexanoate + NADP(+) = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+) + NADPH." [EC:1.3.1.40, RHEA:24271]
synonym: "2,6-dioxo-6-phenylhexanoate:NADP+ delta2-oxidoreductase activity" EXACT [EC:1.3.1.40]
synonym: "2-hydroxy-6-oxo-phenylhexa-2,4-dienoate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.3.1.40]
xref: EC:1.3.1.40
xref: KEGG:R03463
xref: MetaCyc:1.3.1.40-RXN
xref: RHEA:24271
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047119
name: 2-methyl-branched-chain-enoyl-CoA reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-methylbutanoyl-CoA + NAD(+) = 2-methylbut-2-enoyl-CoA + H(+) + NADH." [EC:1.3.1.52, RHEA:24535]
synonym: "2-methyl-branched-chain-acyl-CoA:NAD+ 2-oxidoreductase activity" EXACT [EC:1.3.1.52]
xref: EC:1.3.1.52
xref: KEGG:R03169
xref: MetaCyc:1.3.1.52-RXN
xref: RHEA:24535
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047120
name: (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase activity
namespace: molecular_function
alt_id: GO:0018514
def: "Catalysis of the reaction: (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+) = 3,4-dihydroxybenzoate + CO(2) + NADH." [EC:1.3.1.53, RHEA:10747]
synonym: "(1R,2S)-dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate dehydrogenase activity" EXACT [EC:1.3.1.53]
synonym: "(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.53]
synonym: "cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,4-dicarboxylate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.3.1.53]
synonym: "dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate dehydrogenase activity" EXACT [EC:1.3.1.53]
synonym: "terephthalate 1,2-cis-dihydrodiol dehydrogenase activity" EXACT []
xref: EC:1.3.1.53
xref: KEGG:R01633
xref: MetaCyc:1.3.1.53-RXN
xref: RHEA:10747
xref: UM-BBD_reactionID:r0151
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047121
name: isoquinoline 1-oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: A + H(2)O + isoquinoline = AH(2) + isoquinolin-1(2H)-one." [EC:1.3.99.16, RHEA:11591]
subset: gosubset_prok
synonym: "isoquinoline:acceptor 1-oxidoreductase (hydroxylating)" EXACT [EC:1.3.99.16]
xref: EC:1.3.99.16
xref: KEGG:R05151
xref: MetaCyc:1.3.99.16-RXN
xref: RHEA:11591
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0047122
name: quinaldate 4-oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: A + H(2)O + quinaldate = AH(2) + kynurenate." [EC:1.3.99.18, RHEA:16700]
synonym: "quinaldic acid 4-oxidoreductase activity" EXACT [EC:1.3.99.18]
synonym: "quinoline-2-carboxylate:acceptor 4-oxidoreductase (hydroxylating)" EXACT [EC:1.3.99.18]
xref: EC:1.3.99.18
xref: KEGG:R03687
xref: MetaCyc:1.3.99.18-RXN
xref: RHEA:16700
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0047123
name: quinoline-4-carboxylate 2-oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: A + H(2)O + quinoline-4-carboxylate = 2-oxo-1,2-dihydroquinoline-4-carboxylate + AH(2)." [EC:1.3.99.19, RHEA:14952]
synonym: "quinoline-4-carboxylate:acceptor 2-oxidoreductase (hydroxylating)" EXACT [EC:1.3.99.19]
synonym: "quinoline-4-carboxylic acid 2-oxidoreductase activity" EXACT [EC:1.3.99.19]
xref: EC:1.3.99.19
xref: KEGG:R05183
xref: MetaCyc:1.3.99.19-RXN
xref: RHEA:14952
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0047124
name: L-erythro-3,5-diaminohexanoate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3S,5S)-3,5-diaminohexanoate + H(2)O + NAD(+) = (S)-5-amino-3-oxo-hexanoate + H(+) + NADH + NH(4)(+)." [EC:1.4.1.11, RHEA:19636]
synonym: "L-3,5-diaminohexanoate dehydrogenase activity" EXACT [EC:1.4.1.11]
synonym: "L-erythro-3,5-diaminohexanoate:NAD+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.11]
xref: EC:1.4.1.11
xref: KEGG:R03349
xref: MetaCyc:1.4.1.11-RXN
xref: RHEA:19636
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047125
name: delta1-piperideine-2-carboxylate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + L-pipecolate = NADPH + delta1-piperideine-2-carboxylate." [EC:1.5.1.21]
synonym: "1,2-didehydropipecolate reductase activity" EXACT [EC:1.5.1.21]
synonym: "1,2-didehydropipecolic reductase activity" EXACT [EC:1.5.1.21]
synonym: "D1-piperideine-2-carboxylate reductase activity" EXACT []
synonym: "delta 1-piperideine-2-carboxylate reductase activity" EXACT []
synonym: "L-pipecolate:NADP+ 2-oxidoreductase activity" EXACT [EC:1.5.1.21]
synonym: "P2C reductase activity" EXACT [EC:1.5.1.21]
xref: EC:1.5.1.21
xref: MetaCyc:RXN-8166
xref: RHEA:12527
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047126
name: N5-(carboxyethyl)ornithine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: N(5)-[1(S)-1-carboxyethyl]-L-ornithine + H(2)O + NADP(+) = L-ornithine + H(+) + NADPH + pyruvate." [EC:1.5.1.24, RHEA:18664]
subset: gosubset_prok
synonym: "5-N-(L-1-carboxyethyl)-L-ornithine:NADP+ oxidoreductase (L-ornithine-forming)" EXACT [EC:1.5.1.24]
synonym: "N5-(L-1-carboxyethyl)-L-ornithine:NADP+ oxidoreductase (L-ornithine-forming)" EXACT [EC:1.5.1.24]
xref: EC:1.5.1.24
xref: KEGG:R00666
xref: MetaCyc:1.5.1.24-RXN
xref: RHEA:18664
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047127
name: thiomorpholine-carboxylate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(P)+ + thiomorpholine-3-carboxylate = NAD(P)H + 3,4-dehydro-1,4-thiomorpholine-3-carboxylate." [EC:1.5.1.25, MetaCyc:1.5.1.25-RXN]
synonym: "ketimine reductase activity" EXACT [EC:1.5.1.25]
synonym: "ketimine-reducing enzyme" RELATED [EC:1.5.1.25]
synonym: "thiomorpholine-3-carboxylate:NAD(P)+ 5,6-oxidoreductase activity" EXACT [EC:1.5.1.25]
xref: EC:1.5.1.25
xref: MetaCyc:1.5.1.25-RXN
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047128
name: 1,2-dehydroreticulinium reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-reticuline + NADP(+) = 1,2-dehydroreticuline + H(+) + NADPH." [EC:1.5.1.27, RHEA:17572]
synonym: "(R)-reticuline:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.27]
synonym: "1,2-dehydroreticulinium ion reductase activity" EXACT [EC:1.5.1.27]
xref: EC:1.5.1.27
xref: KEGG:R04695
xref: MetaCyc:1.5.1.27-RXN
xref: RHEA:17572
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047129
name: opine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2S)-2-[(R)-1-carboxyethylamino]pentanoate + H(2)O + NAD(+) = L-2-aminopentanoate + H(+) + NADH + pyruvate." [EC:1.5.1.28, RHEA:21595]
subset: gosubset_prok
synonym: "(2S)-2-{[1-(R)-carboxyethyl]amino}pentanoate dehydrogenase (NAD, L-aminopentanoate-forming)" EXACT [EC:1.5.1.28]
synonym: "(2S)-2-{[1-(R)-carboxyethyl]amino}pentanoate:NAD+ oxidoreductase (L-aminopentanoate-forming)" EXACT [EC:1.5.1.28]
xref: EC:1.5.1.28
xref: KEGG:R03732
xref: MetaCyc:1.5.1.28-RXN
xref: RHEA:21595
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047130
name: saccharopine dehydrogenase (NADP+, L-lysine-forming) activity
namespace: molecular_function
alt_id: GO:0010010
def: "Catalysis of the reaction: L-saccharopine + H(2)O + NADP(+) = 2-oxoglutarate + L-lysine + H(+) + NADPH." [EC:1.5.1.8, RHEA:19376]
subset: gosubset_prok
synonym: "6-N-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)" EXACT [EC:1.5.1.8]
synonym: "L-lysine-alpha-ketoglutarate reductase activity" EXACT [EC:1.5.1.8]
synonym: "lysine:alpha-ketoglutarate:TPNH oxidoreductase (epsilon-N-[gultaryl-2]-L-lysine forming)" EXACT [EC:1.5.1.8]
synonym: "N6-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)" EXACT [EC:1.5.1.8]
synonym: "saccharopine (nicotinamide adenine dinucleotide phosphate, lysine-forming) dehydrogenase activity" EXACT [EC:1.5.1.8]
xref: EC:1.5.1.8
xref: KEGG:R00716
xref: MetaCyc:1.5.1.8-RXN
xref: Reactome:REACT_102914 "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O, Xenopus tropicalis"
xref: Reactome:REACT_105920 "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O, Drosophila melanogaster"
xref: Reactome:REACT_106804 "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O, Danio rerio"
xref: Reactome:REACT_108450 "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O, Dictyostelium discoideum"
xref: Reactome:REACT_28128 "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O, Bos taurus"
xref: Reactome:REACT_31287 "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O, Mus musculus"
xref: Reactome:REACT_75 "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O, Homo sapiens"
xref: Reactome:REACT_78966 "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O, Sus scrofa"
xref: Reactome:REACT_80851 "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O, Saccharomyces cerevisiae"
xref: Reactome:REACT_83042 "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O, Rattus norvegicus"
xref: Reactome:REACT_83747 "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O, Schizosaccharomyces pombe"
xref: Reactome:REACT_87804 "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O, Canis familiaris"
xref: Reactome:REACT_95574 "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O, Oryza sativa"
xref: Reactome:REACT_96269 "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O, Gallus gallus"
xref: Reactome:REACT_99197 "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O, Arabidopsis thaliana"
xref: Reactome:REACT_99253 "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O, Caenorhabditis elegans"
xref: Reactome:REACT_99548 "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O, Taeniopygia guttata"
xref: RHEA:19376
is_a: GO:0004753 ! saccharopine dehydrogenase activity

[Term]
id: GO:0047131
name: saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: L-saccharopine + H(2)O + NAD(+) = L-glutamate + allysine + H(+) + NADH." [EC:1.5.1.9, RHEA:24523]
synonym: "6-N-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-glutamate-forming)" EXACT [EC:1.5.1.9]
synonym: "aminoadipic semialdehyde synthase activity" EXACT [EC:1.5.1.9]
synonym: "dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, glutamate-forming)" EXACT [EC:1.5.1.9]
synonym: "N6-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-glutamate-forming)" EXACT [EC:1.5.1.9]
synonym: "NAD+ oxidoreductase (L-2-aminoadipic-delta-semialdehyde and glutamate forming)" EXACT [EC:1.5.1.9]
synonym: "saccharopin dehydrogenase activity" EXACT [EC:1.5.1.9]
xref: EC:1.5.1.9
xref: KEGG:R02313
xref: MetaCyc:1.5.1.9-RXN
xref: Reactome:REACT_101126 "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+, Gallus gallus"
xref: Reactome:REACT_105271 "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+, Dictyostelium discoideum"
xref: Reactome:REACT_105621 "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+, Saccharomyces cerevisiae"
xref: Reactome:REACT_106339 "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+, Oryza sativa"
xref: Reactome:REACT_106714 "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+, Caenorhabditis elegans"
xref: Reactome:REACT_2132 "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+, Homo sapiens"
xref: Reactome:REACT_32852 "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+, Arabidopsis thaliana"
xref: Reactome:REACT_33639 "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+, Schizosaccharomyces pombe"
xref: Reactome:REACT_33875 "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+, Xenopus tropicalis"
xref: Reactome:REACT_80916 "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+, Bos taurus"
xref: Reactome:REACT_82317 "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+, Rattus norvegicus"
xref: Reactome:REACT_82532 "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+, Sus scrofa"
xref: Reactome:REACT_83676 "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+, Taeniopygia guttata"
xref: Reactome:REACT_88652 "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+, Mus musculus"
xref: Reactome:REACT_91177 "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+, Drosophila melanogaster"
xref: Reactome:REACT_94101 "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+, Canis familiaris"
xref: Reactome:REACT_96670 "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+, Danio rerio"
xref: RHEA:24523
is_a: GO:0004753 ! saccharopine dehydrogenase activity

[Term]
id: GO:0047132
name: dihydrobenzophenanthridine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + dihydrosanguinarine = H2O2 + sanguinarine." [EC:1.5.3.12, MetaCyc:1.5.3.12-RXN]
synonym: "dihydrobenzophenanthridine:oxygen oxidoreductase activity" EXACT [EC:1.5.3.12]
xref: EC:1.5.3.12
xref: MetaCyc:1.5.3.12-RXN
is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor

[Term]
id: GO:0047133
name: dimethylamine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: electron-transferring flavoprotein + H2O + dimethylamine = reduced electron-transferring flavoprotein + formaldehyde + methylamine." [EC:1.5.8.1, MetaCyc:1.5.8.1-RXN]
subset: gosubset_prok
synonym: "dimethylamine:electron-transferring flavoprotein oxidoreductase activity" EXACT [EC:1.5.8.1]
synonym: "DMADh activity" RELATED [EC:1.5.8.1]
xref: EC:1.5.8.1
xref: MetaCyc:1.5.8.1-RXN
xref: UM-BBD_reactionID:r1380
is_a: GO:0046997 ! oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor

[Term]
id: GO:0047134
name: protein-disulfide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein-dithiol + NAD(P)+ = protein-disulfide + NAD(P)H + H+." [EC:1.8.1.8, MetaCyc:1.6.4.4-RXN]
subset: gosubset_prok
synonym: "disulfide reductase activity" EXACT [EC:1.8.1.8]
synonym: "insulin-glutathione transhydrogenase activity" EXACT [EC:1.8.1.8]
synonym: "NAD(P)H2:protein-disulfide oxidoreductase activity" EXACT [EC:1.8.1.8]
synonym: "NAD(P)H:protein-disulfide oxidoreductase activity" EXACT [EC:1.8.1.8]
synonym: "protein disulfide reductase activity" EXACT [EC:1.8.1.8]
synonym: "protein disulphide reductase activity" EXACT [EC:1.8.1.8]
synonym: "protein-disulfide reductase (NAD(P)H) activity" EXACT []
synonym: "protein-disulphide reductase activity" EXACT []
synonym: "protein-dithiol:NAD(P)+ oxidoreductase activity" EXACT [EC:1.8.1.8]
xref: EC:1.8.1.8
xref: MetaCyc:1.6.4.4-RXN
is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor

[Term]
id: GO:0047135
name: bis-gamma-glutamylcystine reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 L-gamma-glutamyl-L-cysteine + NADP(+) = bis-gamma-glutamylcystine + H(+) + NADPH." [EC:1.8.1.13, RHEA:11983]
synonym: "bis-g-glutamylcystine reductase (NADPH) activity" EXACT []
synonym: "Bis-gamma-glutamylcystine reductase (NADPH)" EXACT [EC:1.8.1.13]
synonym: "bis-gamma-glutamylcystine reductase (NADPH) activity" EXACT [EC:1.8.1.13]
synonym: "gamma-glutamylcysteine:NADP+ oxidoreductase activity" EXACT [EC:1.8.1.13]
synonym: "NADPH2:bis-gamma-glutamylcysteine oxidoreductase activity" EXACT [EC:1.8.1.13]
synonym: "NADPH:bis-gamma-glutamylcysteine oxidoreductase activity" EXACT [EC:1.8.1.13]
xref: EC:1.8.1.13
xref: KEGG:R02742
xref: MetaCyc:1.6.4.9-RXN
xref: RHEA:11983
is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor

[Term]
id: GO:0047136
name: 4-(dimethylamino)phenylazoxybenzene reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-(dimethylamino)azobenzene + H(2)O + NADP(+) = 4-(dimethylamino)phenylazoxybenzene + H(+) + NADPH." [EC:1.7.1.11, RHEA:19792]
synonym: "4-(dimethylamino)phenylazobenzene:NADP+ oxidoreductase activity" EXACT [EC:1.7.1.11]
synonym: "dimethylaminoazobenzene N-oxide reductase activity" EXACT [EC:1.7.1.11]
synonym: "N,N-dimethyl-p-aminoazobenzene oxide reductase activity" EXACT [EC:1.7.1.11]
synonym: "NADPH-dependent DMAB N-oxide reductase activity" EXACT [EC:1.7.1.11]
synonym: "NADPH2:4-(dimethylamino)phenylazoxybenzene oxidoreductase activity" EXACT [EC:1.7.1.11]
synonym: "NADPH:4-(dimethylamino)phenylazoxybenzene oxidoreductase activity" EXACT [EC:1.7.1.11]
xref: EC:1.7.1.11
xref: KEGG:R04303
xref: MetaCyc:1.6.6.12-RXN
xref: RHEA:19792
is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor

[Term]
id: GO:0047137
name: N-hydroxy-2-acetamidofluorene reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-acetamidofluorene + NAD(P)+ + H2O = N-hydroxy-2-acetamidofluorene + NAD(P)H + H+." [EC:1.7.1.12, MetaCyc:1.7.1.12-RXN]
synonym: "2-acetamidofluorene:NAD(P)+ oxidoreductase activity" EXACT [EC:1.7.1.12]
synonym: "N-hydroxy-2-acetylaminofluorene reductase activity" EXACT [EC:1.7.1.12]
synonym: "NAD(P)H2:N-hydroxy-2-acetamidofluorene N-oxidoreductase activity" EXACT [EC:1.7.1.12]
synonym: "NAD(P)H:N-hydroxy-2-acetamidofluorene N-oxidoreductase activity" EXACT [EC:1.7.1.12]
xref: EC:1.7.1.12
xref: MetaCyc:1.7.1.12-RXN
is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor

[Term]
id: GO:0047138
name: aquacobalamin reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 cob(II)alamin + NAD+ = 2 aquacob(III)alamin + NADH + H+." [EC:1.16.1.3, MetaCyc:1.6.99.12-RXN]
subset: gosubset_prok
synonym: "aquocobalamin reductase activity" EXACT [EC:1.16.1.3]
synonym: "B(12a) reductase activity" EXACT [EC:1.16.1.3]
synonym: "B12a reductase activity" EXACT [EC:1.16.1.3]
synonym: "cob(II)alamin:NAD+ oxidoreductase activity" EXACT [EC:1.16.1.3]
synonym: "NADH-linked aquacobalamin reductase activity" EXACT [EC:1.16.1.3]
synonym: "NADH2:cob(III)alamin oxidoreductase activity" EXACT [EC:1.16.1.3]
synonym: "NADH:cob(III)alamin oxidoreductase activity" EXACT [EC:1.16.1.3]
synonym: "vitamin B(12a) reductase activity" EXACT [EC:1.16.1.3]
synonym: "vitamin B12a reductase activity" EXACT [EC:1.16.1.3]
xref: EC:1.16.1.3
xref: MetaCyc:AQUACOBALAMIN-REDUCTASE-RXN
xref: RHEA:24475
is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor

[Term]
id: GO:0047139
name: glutathione-homocystine transhydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: homocystine + 2 reduced glutathione = oxidized glutathione + 2 homocysteine." [EC:1.8.4.1, MetaCyc:1.8.4.1-RXN]
synonym: "glutathione:homocystine oxidoreductase activity" EXACT [EC:1.8.4.1]
xref: EC:1.8.4.1
xref: MetaCyc:1.8.4.1-RXN
xref: RHEA:11467
is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor

[Term]
id: GO:0047140
name: glutathione-CoA-glutathione transhydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: oxidized glutathione + CoA = reduced glutathione + CoA-glutathione." [EC:1.8.4.3, MetaCyc:1.8.4.3-RXN]
synonym: "CoA:glutathione-disulfide oxidoreductase activity" EXACT [EC:1.8.4.3]
synonym: "coenzyme A:glutathione-disulfide oxidoreductase activity" EXACT [EC:1.8.4.3]
synonym: "coenzyme A:oxidized-glutathione oxidoreductase activity" EXACT [EC:1.8.4.3]
synonym: "glutathione coenzyme A-glutathione transhydrogenase activity" EXACT [EC:1.8.4.3]
synonym: "glutathione-coenzyme A glutathione disulfide transhydrogenase activity" EXACT [EC:1.8.4.3]
synonym: "glutathione:coenzyme A-glutathione transhydrogenase activity" EXACT [EC:1.8.4.3]
xref: EC:1.8.4.3
xref: MetaCyc:1.8.4.3-RXN
xref: RHEA:13128
is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor

[Term]
id: GO:0047141
name: glutathione-cystine transhydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cystine + 2 reduced glutathione = oxidized glutathione + 2 L-cysteine." [EC:1.8.4.4, MetaCyc:1.8.4.4-RXN]
synonym: "glutathione:cystine oxidoreductase" EXACT [EC:1.8.4.4]
synonym: "GSH-cystine transhydrogenase" EXACT [EC:1.8.4.4]
synonym: "NADPH-dependent GSH-cystine transhydrogenase" EXACT [EC:1.8.4.4]
xref: EC:1.8.4.4
xref: MetaCyc:1.8.4.4-RXN
xref: RHEA:12616
is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor

[Term]
id: GO:0047142
name: enzyme-thiol transhydrogenase (glutathione-disulfide) activity
namespace: molecular_function
def: "Catalysis of the reaction: oxidized glutathione + [xanthine dehydrogenase] = reduced glutathione + xanthine-oxidase." [EC:1.8.4.7, MetaCyc:1.8.4.7-RXN]
synonym: "[xanthine-dehydrogenase]:oxidized-glutathione S-oxidoreductase activity" EXACT [EC:1.8.4.7]
synonym: "enzyme-thiol transhydrogenase (glutathione-disulphide) activity" EXACT []
synonym: "enzyme-thiol transhydrogenase (oxidized-glutathione) activity" EXACT []
synonym: "glutathione-dependent thiol:disulfide oxidoreductase activity" EXACT [EC:1.8.4.7]
synonym: "thiol:disulfide oxidoreductase activity" EXACT [EC:1.8.4.7]
synonym: "thiol:disulphide oxidoreductase activity" EXACT [EC:1.8.4.7]
synonym: "xanthine-dehydrogenase:glutathione-disulfide S-oxidoreductase activity" EXACT [EC:1.8.4.7]
synonym: "xanthine-dehydrogenase:oxidized-glutathione S-oxidoreductase activity" EXACT [EC:1.8.4.7]
xref: EC:1.8.4.7
xref: MetaCyc:1.8.4.7-RXN
is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor

[Term]
id: GO:0047143
name: chlorate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: AH(2) + chlorate = A + chlorite + H(2)O + H(+)." [EC:1.97.1.1, RHEA:16352]
subset: gosubset_prok
synonym: "chlorate reductase C" RELATED [EC:1.97.1.1]
synonym: "chlorite:acceptor oxidoreductase activity" EXACT [EC:1.97.1.1]
xref: EC:1.97.1.1
xref: KEGG:R03575
xref: MetaCyc:1.97.1.1-RXN
xref: RHEA:16352
xref: UM-BBD_reactionID:r0981
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0047144
name: 2-acylglycerol-3-phosphate O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-acyl-sn-glycerol 3-phosphate + acyl-CoA = L-phosphatidate + CoA." [EC:2.3.1.52, GOC:ab, MetaCyc:2-ACYL2.3.1.15-RXN, RHEA:14236]
synonym: "2-acylglycerophosphate acyltransferase activity" EXACT [EC:2.3.1.52]
synonym: "acyl-CoA:2-acyl-sn-glycerol 3-phosphate O-acyltransferase activity" EXACT [EC:2.3.1.52]
xref: EC:2.3.1.52
xref: MetaCyc:2-ACYL2.3.1.15-RXN
is_a: GO:0008374 ! O-acyltransferase activity
is_a: GO:0042171 ! lysophosphatidic acid acyltransferase activity

[Term]
id: GO:0047145
name: demethylsterigmatocystin 6-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-demethylsterigmatocystin + S-adenosyl-L-methionine = sterigmatocystin + S-adenosyl-homocysteine." [EC:2.1.1.109, MetaCyc:2.1.1.109-RXN]
synonym: "demethylsterigmatocystin methyltransferase activity" EXACT [EC:2.1.1.109]
synonym: "O-methyltransferase I" RELATED [EC:2.1.1.109]
synonym: "S-adenosyl-L-methionine:6-demethylsterigmatocystin 6-O-methyltransferase activity" EXACT [EC:2.1.1.109]
xref: EC:2.1.1.109
xref: MetaCyc:2.1.1.109-RXN
xref: RHEA:11507
is_a: GO:0008171 ! O-methyltransferase activity

[Term]
id: GO:0047146
name: sterigmatocystin 7-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: sterigmatocystin + S-adenosyl-L-methionine = 7-O-methylsterigmatocystin + S-adenosyl-homocysteine." [EC:2.1.1.110, MetaCyc:2.1.1.110-RXN]
synonym: "O-methyltransferase II activity" RELATED [EC:2.1.1.110]
synonym: "S-adenosyl-L-methionine:sterigmatocystin 7-O-methyltransferase activity" EXACT [EC:2.1.1.110]
synonym: "S-adenosyl-L-methionine:sterigmatocystin 8-O-methyltransferase activity" EXACT [EC:2.1.1.110]
synonym: "sterigmatocystin 8-O-methyltransferase activity" EXACT [EC:2.1.1.110]
synonym: "sterigmatocystin methyltransferase activity" EXACT [EC:2.1.1.110]
xref: EC:2.1.1.110
xref: MetaCyc:2.1.1.110-RXN
xref: RHEA:15564
is_a: GO:0008171 ! O-methyltransferase activity

[Term]
id: GO:0047147
name: trimethylsulfonium-tetrahydrofolate N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (6S)-5,6,7,8-tetrahydrofolate + trimethylsulfonium = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + dimethyl sulfide + H(+)." [EC:2.1.1.19, RHEA:13696]
synonym: "trimethylsulfonium-tetrahydrofolate methyltransferase activity" EXACT [EC:2.1.1.19]
synonym: "trimethylsulfonium:tetrahydrofolate N-methyltransferase activity" EXACT [EC:2.1.1.19]
synonym: "trimethylsulphonium-tetrahydrofolate N-methyltransferase activity" EXACT []
xref: EC:2.1.1.19
xref: KEGG:R02573
xref: MetaCyc:2.1.1.19-RXN
xref: RHEA:13696
is_a: GO:0008170 ! N-methyltransferase activity

[Term]
id: GO:0047148
name: methylamine-glutamate N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamate + methylammonium = N-methyl-L-glutamate + NH(4)(+)." [EC:2.1.1.21, RHEA:15840]
synonym: "methylamine-glutamate methyltransferase activity" EXACT [EC:2.1.1.21]
synonym: "methylamine:L-glutamate N-methyltransferase activity" EXACT [EC:2.1.1.21]
synonym: "N-methylglutamate synthase activity" EXACT [EC:2.1.1.21]
xref: EC:2.1.1.21
xref: KEGG:R01586
xref: MetaCyc:2.1.1.21-RXN
xref: RHEA:15840
is_a: GO:0008170 ! N-methyltransferase activity

[Term]
id: GO:0047149
name: thetin-homocysteine S-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-homocysteine + dimethylsulfonioacetate = (methylthio)acetate + L-methionine + H(+)." [EC:2.1.1.3, RHEA:22791]
synonym: "dimethylsulfonioacetate:L-homocysteine S-methyltransferase activity" EXACT [EC:2.1.1.3]
synonym: "dimethylthetin-homocysteine methyltransferase activity" EXACT [EC:2.1.1.3]
synonym: "thetin-homocysteine methylpherase activity" EXACT [EC:2.1.1.3]
xref: EC:2.1.1.3
xref: KEGG:R04153
xref: MetaCyc:2.1.1.3-RXN
xref: RHEA:22791
is_a: GO:0008172 ! S-methyltransferase activity

[Term]
id: GO:0047150
name: betaine-homocysteine S-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-homocysteine + betaine = N,N-dimethylglycine + L-methionine." [EC:2.1.1.5, RHEA:22339]
synonym: "betaine-homocysteine methyltransferase activity" EXACT [EC:2.1.1.5]
synonym: "betaine-homocysteine transmethylase activity" EXACT [EC:2.1.1.5]
synonym: "trimethylammonioacetate:L-homocysteine S-methyltransferase activity" EXACT [EC:2.1.1.5]
xref: EC:2.1.1.5
xref: KEGG:R02821
xref: MetaCyc:2.1.1.5-RXN
xref: Reactome:REACT_115861 "Remethylation of homocysteine via betaine degradation, Homo sapiens"
xref: RHEA:22339
is_a: GO:0008172 ! S-methyltransferase activity

[Term]
id: GO:0047151
name: methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + tRNA containing uridine at position 54 + FADH + H+ = tetrahydrofolate + tRNA containing ribothymidine at position 54 + FAD+." [EC:2.1.1.74, MetaCyc:2.1.1.74-RXN]
synonym: "5,10-methylenetetrahydrofolate:tRNA (uracil-5-)-methyltransferase activity" EXACT [EC:2.1.1.74]
synonym: "5,10-methylenetetrahydrofolate:tRNA-UPsiC (uracil-5-)-methyl-transferase activity" EXACT [EC:2.1.1.74]
synonym: "folate-dependent ribothymidyl synthase activity" EXACT [EC:2.1.1.74]
synonym: "methylenetetrahydrofolate-transfer ribonucleate uracil 5-methyltransferase activity" EXACT [EC:2.1.1.74]
synonym: "methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH-oxidizing) activity" EXACT []
xref: EC:2.1.1.74
xref: KEGG:R03704
xref: MetaCyc:2.1.1.74-RXN
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0047152
name: methanol-5-hydroxybenzimidazolylcobamide Co-methyltransferase activity
namespace: molecular_function
alt_id: GO:1990087
def: "Catalysis of the reaction: 5-hydroxybenzimidazolylcobamide + methanol = H2O + Co-methyl-Co-5-hydroxybenzimidazolylcob(I)amide." [EC:2.1.1.90, MetaCyc:2.1.1.90-RXN]
comment: This function is the first step in the pathway of methanogenesis from methanol.
subset: gosubset_prok
synonym: "methanol cobalamin methyltransferase activity" EXACT [EC:2.1.1.90]
synonym: "methanol-corrinoid protein Co-methyltransferase." EXACT []
synonym: "methanol:5-hydroxybenzimidazolylcobamide Co-methyltransferase activity" EXACT [EC:2.1.1.90]
synonym: "methanol:5-hydroxybenzimidazolylcobamide methyltransferase activity" EXACT [EC:2.1.1.90]
synonym: "methanol:corrinoid methyltransferase activity" EXACT []
synonym: "methyltransferase 1" BROAD []
synonym: "MT 1" RELATED [EC:2.1.1.90]
synonym: "MT1" RELATED []
synonym: "MtaB" RELATED []
xref: EC:2.1.1.90
xref: MetaCyc:2.1.1.90-RXN
xref: RHEA:21347
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0047153
name: deoxycytidylate 5-hydroxymethyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dCMP + H(2)O = (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyldeoxycytidylate." [EC:2.1.2.8, RHEA:11283]
synonym: "5,10-methylenetetrahydrofolate:deoxycytidylate 5-hydroxymethyltransferase activity" EXACT [EC:2.1.2.8]
synonym: "d-cytidine 5'-monophosphate hydroxymethylase activity" EXACT [EC:2.1.2.8]
synonym: "dCMP hydroxymethylase activity" EXACT [EC:2.1.2.8]
synonym: "deoxyCMP hydroxymethylase activity" EXACT [EC:2.1.2.8]
synonym: "deoxycytidylate hydroxymethylase activity" EXACT [EC:2.1.2.8]
synonym: "deoxycytidylate hydroxymethyltransferase activity" EXACT []
synonym: "deoxycytidylic hydroxymethylase activity" EXACT [EC:2.1.2.8]
xref: EC:2.1.2.8
xref: KEGG:R01669
xref: MetaCyc:2.1.2.8-RXN
xref: RHEA:11283
is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity

[Term]
id: GO:0047154
name: methylmalonyl-CoA carboxytransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyruvate + D-methylmalonyl-CoA = oxaloacetic acid + propionyl-CoA." [EC:2.1.3.1, MetaCyc:2.1.3.1-RXN]
subset: gosubset_prok
synonym: "(S)-2-methyl-3-oxopropanoyl-CoA:pyruvate" RELATED [EC:2.1.3.1]
synonym: "(S)-2-methyl-3-oxopropanoyl-CoA:pyruvate carboxyltransferase activity" EXACT [EC:2.1.3.1]
synonym: "(S)-methylmalonyl-CoA:pyruvate carboxyltransferase activity" EXACT [EC:2.1.3.1]
synonym: "(S)-methylmalonyl-CoA:pyruvate carboxytransferase activity" EXACT [EC:2.1.3.1]
synonym: "methylmalonyl coenzyme A carboxyltransferase activity" EXACT [EC:2.1.3.1]
synonym: "methylmalonyl-CoA carboxyltransferase activity" EXACT []
synonym: "methylmalonyl-CoA transcarboxylase activity" EXACT [EC:2.1.3.1]
synonym: "oxalacetic transcarboxylase activity" EXACT [EC:2.1.3.1]
synonym: "transcarboxylase activity" RELATED [EC:2.1.3.1]
xref: EC:2.1.3.1
xref: MetaCyc:2.1.3.1-RXN
xref: RHEA:20767
xref: UM-BBD_reactionID:r0923
is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity

[Term]
id: GO:0047155
name: 3-hydroxymethylcephem carbamoyltransferase activity
namespace: molecular_function
alt_id: GO:0045447
def: "Catalysis of the reaction: a 3-hydroxymethylceph-3-em-4-carboxylate + carbamoyl-phosphate = phosphate + a 3-carbamoyloxymethylcephem." [EC:2.1.3.7, MetaCyc:2.1.3.7-RXN]
synonym: "3'-hydroxymethylcephem-O-carbamoyltransferase activity" EXACT []
synonym: "carbamoyl-phosphate:3-hydroxymethylceph-3-em-4-carboxylate carbamoyltransferase activity" EXACT [EC:2.1.3.7]
xref: EC:2.1.3.7
xref: MetaCyc:2.1.3.7-RXN
is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity

[Term]
id: GO:0047156
name: acetoin-ribose-5-phosphate transaldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-ribose 5-phosphate + acetoin = 1-deoxy-D-altro-heptulose 7-phosphate + acetaldehyde." [EC:2.2.1.4, RHEA:21507]
synonym: "1-deoxy-D-altro-heptulose-7-phosphate synthase activity" EXACT [EC:2.2.1.4]
synonym: "1-deoxy-D-altro-heptulose-7-phosphate synthetase activity" EXACT [EC:2.2.1.4]
synonym: "3-hydroxybutan-2-one:D-ribose-5-phosphate aldehydetransferase activity" EXACT [EC:2.2.1.4]
synonym: "3-hydroxybutan-3-one:D-ribose-5-phosphate aldehydetransferase activity" EXACT [EC:2.2.1.4]
xref: EC:2.2.1.4
xref: KEGG:R02345
xref: MetaCyc:2.2.1.4-RXN
xref: RHEA:21507
is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups

[Term]
id: GO:0047157
name: myelin-proteolipid O-palmitoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: [myelin proteolipid] + palmityl-CoA = [myelin proteolipid] O-palmitoylprotein + CoA." [EC:2.3.1.100, MetaCyc:2.3.1.100-RXN]
synonym: "[myelin-proteolipid] O-palmitoyltransferase activity" EXACT [EC:2.3.1.100]
synonym: "acyl-protein synthase activity" BROAD [EC:2.3.1.100]
synonym: "myelin PLP acyltransferase activity" EXACT [EC:2.3.1.100]
synonym: "palmitoyl-CoA:[myelin-proteolipid] O-palmitoyltransferase activity" EXACT [EC:2.3.1.100]
xref: EC:2.3.1.100
xref: MetaCyc:2.3.1.100-RXN
is_a: GO:0016416 ! O-palmitoyltransferase activity

[Term]
id: GO:0047158
name: sinapoylglucose-sinapoylglucose O-sinapoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 1-O-sinapoyl-beta-D-glucose = 1,2-di-O-sinapoyl-beta-D-glucose + D-glucose." [EC:2.3.1.103, RHEA:22667]
synonym: "1-(hydroxycinnamoyl)-glucose:1-(hydroxycinnamoyl)-glucose hydroxycinnamoyltransferase activity" EXACT [EC:2.3.1.103]
synonym: "1-O-(4-hydroxy-3,5-dimethoxycinnamoyl)-beta-D-glucoside:1-O-(4-hydroxy-3,5-dimethoxycinnamoyl-beta-D-glucoside 1-O-sinapoyltransferase activity" EXACT [EC:2.3.1.103]
synonym: "hydroxycinnamoylglucose-hydroxycinnamoylglucose hydroxycinnamoyltransferase activity" EXACT [EC:2.3.1.103]
xref: EC:2.3.1.103
xref: KEGG:R00063
xref: MetaCyc:2.3.1.103-RXN
xref: RHEA:22667
is_a: GO:0016753 ! O-sinapoyltransferase activity

[Term]
id: GO:0047159
name: 1-alkenylglycerophosphocholine O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-alkenylglycerophosphocholine + acyl-CoA = 1-alkenyl-2-acylglycerophosphocholine + CoA." [EC:2.3.1.104, MetaCyc:2.3.1.104-RXN]
synonym: "acyl-CoA:1-alkenylglycerophosphocholine O-acyltransferase activity" EXACT [EC:2.3.1.104]
xref: EC:2.3.1.104
xref: MetaCyc:2.3.1.104-RXN
xref: RHEA:10347
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0047160
name: alkylglycerophosphate 2-O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-alkyl-sn-glycerol 3-phosphate + acetyl-CoA = 1-alkyl-2-acetyl-sn-glycerol 3-phosphate + CoA." [EC:2.3.1.105, RHEA:18560]
synonym: "acetyl-CoA:1-alkyl-sn-glycero-3-phosphate 2-O-acetyltransferase activity" EXACT [EC:2.3.1.105]
synonym: "alkyllyso-GP:acetyl-CoA acetyltransferase activity" EXACT [EC:2.3.1.105]
xref: EC:2.3.1.105
xref: KEGG:R03455
xref: MetaCyc:2.3.1.105-RXN
xref: RHEA:18560
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0047161
name: tartronate O-hydroxycinnamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydroxymalonate + sinapoyl-CoA = CoA + sinapoyltartronate." [EC:2.3.1.106, RHEA:10955]
synonym: "hydroxycinnamoyl-coenzyme-A:tartronate hydroxycinnamoyltransferase activity" EXACT [EC:2.3.1.106]
synonym: "sinapoyl-CoA:2-hydroxymalonate O-(hydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.106]
synonym: "tartronate sinapoyltransferase activity" EXACT [EC:2.3.1.106]
xref: EC:2.3.1.106
xref: KEGG:R03965
xref: MetaCyc:2.3.1.106-RXN
xref: RHEA:10955
is_a: GO:0050737 ! O-hydroxycinnamoyltransferase activity

[Term]
id: GO:0047162
name: 17-O-deacetylvindoline O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (1R,9R,10S,11R,12R,19R)-12-ethyl-10,11-dihydroxy-5-methoxy-10-(methoxycarbonyl)-8-methyl-8,16-diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-2(7),3,5,13-tetraen-16-ium + acetyl-CoA = (1R,9R,10S,11R,12R,19R)-11-(acetyloxy)-12-ethyl-10-hydroxy-5-methoxy-10-(methoxycarbonyl)-8-methyl-8,16-diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-2(7),3,5,13-tetraen-16-ium + CoA." [EC:2.3.1.107, RHEA:24499]
synonym: "17-O-deacetylvindoline-17-O-acetyltransferase activity" EXACT [EC:2.3.1.107]
synonym: "acetyl-CoA-17-O-deacetylvindoline 17-O-acetyltransferase activity" EXACT [EC:2.3.1.107]
synonym: "acetyl-CoA:17-O-deacetylvindoline 17-O-acetyltransferase activity" EXACT [EC:2.3.1.107]
synonym: "acetyl-CoA:deacetylvindoline 4-O-acetyltransferase activity" EXACT [EC:2.3.1.107]
synonym: "acetylcoenzyme A-deacetylvindoline 4-O-acetyltransferase activity" EXACT [EC:2.3.1.107]
synonym: "acetylcoenzyme A:deacetylvindoline 4-O-acetyltransferase activity" EXACT [EC:2.3.1.107]
synonym: "acetylcoenzyme A:deacetylvindoline O-acetyltransferase activity" EXACT [EC:2.3.1.107]
synonym: "DAT activity" EXACT [EC:2.3.1.107]
synonym: "deacetylvindoline acetyltransferase activity" EXACT [EC:2.3.1.107]
synonym: "deacetylvindoline O-acetyltransferase activity" EXACT [EC:2.3.1.107]
xref: EC:2.3.1.107
xref: KEGG:R03230
xref: MetaCyc:2.3.1.107-RXN
xref: RHEA:24499
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0047163
name: 3,4-dichloroaniline N-malonyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,4-dichloroaniline + malonyl-CoA = N-(3,4-dichlorophenyl)malonamate + CoA." [EC:2.3.1.114, RHEA:21063]
synonym: "malonyl-CoA:3,4-dichloroaniline N-malonyltransferase activity" EXACT [EC:2.3.1.114]
xref: EC:2.3.1.114
xref: KEGG:R04050
xref: MetaCyc:2.3.1.114-RXN
xref: RHEA:21063
is_a: GO:0050735 ! N-malonyltransferase activity

[Term]
id: GO:0047164
name: isoflavone-7-O-beta-glucoside 6''-O-malonyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: biochanin-A + malonyl-CoA = 6'-malonyl-biochanin A + CoA." [EC:2.3.1.115, MetaCyc:2.3.1.115-RXN]
synonym: "flavone (flavonol) 7-O-glycoside malonyltransferase activity" EXACT [EC:2.3.1.115]
synonym: "flavone/flavonol 7-O-beta-D-glucoside malonyltransferase activity" EXACT [EC:2.3.1.115]
synonym: "malonyl-CoA:flavone/flavonol 7-O-glucoside malonyltransferase activity" EXACT [EC:2.3.1.115]
synonym: "malonyl-CoA:isoflavone-7-O-beta-D-glucoside 6''-O-malonyltransferase activity" EXACT [EC:2.3.1.115]
synonym: "malonyl-coenzyme A:flavone/flavonol-7-O-glycoside malonyltransferase activity" EXACT [EC:2.3.1.115]
synonym: "malonyl-coenzyme A:isoflavone 7-O-glucoside-6''-malonyltransferase activity" EXACT [EC:2.3.1.115]
synonym: "MAT-7" RELATED [EC:2.3.1.115]
xref: EC:2.3.1.115
xref: MetaCyc:2.3.1.115-RXN
xref: RHEA:15584
is_a: GO:0050736 ! O-malonyltransferase activity

[Term]
id: GO:0047165
name: flavonol-3-O-beta-glucoside O-malonyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: flavonol 3-O-beta-D-glucoside + malonyl-CoA = malonyl-flavonol 3-O-beta-D-glucoside + CoA." [EC:2.3.1.116, MetaCyc:2.3.1.116-RXN]
synonym: "flavonol 3-O-glucoside malonyltransferase activity" EXACT [EC:2.3.1.116]
synonym: "malonyl-CoA:flavonol-3-O-beta-D-glucoside 6''-O-malonyltransferase activity" EXACT [EC:2.3.1.116]
synonym: "malonyl-coenzyme A:flavonol-3-O-glucoside malonyltransferase activity" EXACT [EC:2.3.1.116]
synonym: "MAT-3" RELATED [EC:2.3.1.116]
xref: EC:2.3.1.116
xref: MetaCyc:2.3.1.116-RXN
xref: RHEA:20088
is_a: GO:0050736 ! O-malonyltransferase activity

[Term]
id: GO:0047166
name: 1-alkenylglycerophosphoethanolamine O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-alkenylglycerophosphoethanolamine + acyl-CoA = 1-alkenyl-2-acyl-glycerophosphoethanolamine + CoA." [EC:2.3.1.121, MetaCyc:2.3.1.121-RXN]
synonym: "acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase activity" EXACT [EC:2.3.1.121]
xref: EC:2.3.1.121
xref: MetaCyc:2.3.1.121-RXN
xref: RHEA:16248
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0047167
name: 1-alkyl-2-acetylglycerol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-O-alkyl-2-acetyl-sn-glycerol + acyl-CoA = 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + CoA." [EC:2.3.1.125, MetaCyc:2.3.1.125-RXN]
synonym: "1-hexadecyl-2-acetylglycerol acyltransferase activity" EXACT [EC:2.3.1.125]
synonym: "acyl-CoA:1-O-alkyl-2-acetyl-sn-glycerol O-acyltransferase activity" EXACT [EC:2.3.1.125]
xref: EC:2.3.1.125
xref: MetaCyc:2.3.1.125-RXN
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0047168
name: isocitrate O-dihydroxycinnamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: caffeoyl-CoA + isocitrate = 2-caffeoylisocitrate + CoA." [EC:2.3.1.126, RHEA:20759]
synonym: "caffeoyl-CoA:isocitrate 3-O-(3,4-dihydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.126]
xref: EC:2.3.1.126
xref: KEGG:R01946
xref: MetaCyc:2.3.1.126-RXN
xref: RHEA:20759
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0047169
name: galactarate O-hydroxycinnamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: feruloyl-CoA + galactarate = 2-(E)-O-feruloyl-D-galactarate + CoA." [EC:2.3.1.130, RHEA:13000]
synonym: "feruloyl-CoA:galactarate O-(hydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.130]
synonym: "galacturate hydroxycinnamoyltransferase activity" EXACT [EC:2.3.1.130]
xref: EC:2.3.1.130
xref: KEGG:R03727
xref: MetaCyc:2.3.1.130-RXN
xref: RHEA:13000
is_a: GO:0050737 ! O-hydroxycinnamoyltransferase activity

[Term]
id: GO:0047170
name: glucarate O-hydroxycinnamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucarate + sinapoyl-CoA = 2-O-sinapoyl-D-glucarate + CoA." [EC:2.3.1.131, RHEA:23311]
synonym: "sinapoyl-CoA:glucarate O-(hydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.131]
xref: EC:2.3.1.131
xref: KEGG:R02899
xref: MetaCyc:2.3.1.131-RXN
xref: RHEA:23311
is_a: GO:0050737 ! O-hydroxycinnamoyltransferase activity

[Term]
id: GO:0047171
name: glucarolactone O-hydroxycinnamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: glucarolactone + sinapoyl-CoA = O-sinapoylglucarolactone + CoA." [EC:2.3.1.132, MetaCyc:2.3.1.132-RXN]
synonym: "sinapoyl-CoA:glucarolactone O-(hydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.132]
xref: EC:2.3.1.132
xref: MetaCyc:2.3.1.132-RXN
xref: RHEA:14264
is_a: GO:0050737 ! O-hydroxycinnamoyltransferase activity

[Term]
id: GO:0047172
name: shikimate O-hydroxycinnamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: shikimate + coumaroyl-CoA = 4-coumaroylshikimate + CoA." [EC:2.3.1.133, MetaCyc:2.3.1.133-RXN]
synonym: "4-coumaroyl-CoA:shikimate O-(hydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.133]
synonym: "shikimate hydroxycinnamoyltransferase activity" EXACT [EC:2.3.1.133]
xref: EC:2.3.1.133
xref: MetaCyc:2.3.1.133-RXN
xref: RHEA:12127
is_a: GO:0050737 ! O-hydroxycinnamoyltransferase activity

[Term]
id: GO:0047173
name: phosphatidylcholine-retinol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: retinol-[cellular-retinol-binding-protein] + phosphatidylcholine = retinyl-ester-[cellular-retinol-binding-protein] + 2-acylglycerophosphocholine." [EC:2.3.1.135, MetaCyc:2.3.1.135-RXN]
synonym: "lecithin--retinol acyltransferase activity" EXACT [EC:2.3.1.135]
synonym: "phosphatidylcholine:retinol-(cellular-retinol-binding-protein) O-acyltransferase activity" EXACT [EC:2.3.1.135]
synonym: "phosphatidylcholine:retinol-[cellular-retinol-binding-protein] O-acyltransferase activity" EXACT [EC:2.3.1.135]
xref: EC:2.3.1.135
xref: MetaCyc:2.3.1.135-RXN
xref: Reactome:REACT_25108 "Esterification of retinol, Homo sapiens"
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0047174
name: putrescine N-hydroxycinnamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: caffeoyl-CoA + putrescine = N-caffeoylputrescine + CoA + H(+)." [EC:2.3.1.138, RHEA:12439]
synonym: "caffeoyl-CoA putrescine N-caffeoyl transferase activity" EXACT [EC:2.3.1.138]
synonym: "caffeoyl-CoA:putrescine N-(3,4-dihydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.138]
synonym: "hydroxycinnamoyl-CoA:putrescine hydroxycinnamoyltransferase activity" EXACT [EC:2.3.1.138]
synonym: "PHT" RELATED [EC:2.3.1.138]
synonym: "putrescine hydroxycinnamoyl transferase activity" EXACT [EC:2.3.1.138]
synonym: "putrescine hydroxycinnamoyltransferase activity" EXACT [EC:2.3.1.138]
xref: EC:2.3.1.138
xref: KEGG:R01944
xref: MetaCyc:2.3.1.138-RXN
xref: RHEA:12439
is_a: GO:0016410 ! N-acyltransferase activity
is_a: GO:0050734 ! hydroxycinnamoyltransferase activity

[Term]
id: GO:0047175
name: galactosylacylglycerol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: sn-3-D-galactosyl-sn-2-acylglycerol + acyl-[acyl-carrier protein] = D-galactosyldiacylglycerol + [acyl-carrier protein]." [EC:2.3.1.141, MetaCyc:2.3.1.141-RXN]
synonym: "acyl-ACP:lyso-MGDG acyltransferase activity" EXACT [EC:2.3.1.141]
synonym: "acyl-acyl-carrier protein: lysomonogalactosyldiacylglycerol acyltransferase activity" EXACT [EC:2.3.1.141]
synonym: "acyl-acyl-carrier-protein:D-galactosylacylglycerol O-acyltransferase activity" EXACT [EC:2.3.1.141]
xref: EC:2.3.1.141
xref: MetaCyc:2.3.1.141-RXN
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0047176
name: beta-glucogallin-tetrakisgalloylglucose O-galloyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2,3,6-tetrakis-O-galloyl-beta-D-glucose + 1-O-galloyl-beta-D-glucose = 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + D-glucose." [EC:2.3.1.143, RHEA:19112]
synonym: "1-O-galloyl-beta-D-glucose:1,2,3,6-tetrakis-O-galloyl-beta-D-glucose 4-O-galloyltransferase activity" EXACT [EC:2.3.1.143]
synonym: "beta-glucogallin-tetragalloylglucose 4-galloyltransferase activity" EXACT [EC:2.3.1.143]
synonym: "beta-glucogallin:1,2,3,6-tetra-O-galloyl-beta-D-glucose 4-O-galloyltransferase activity" EXACT [EC:2.3.1.143]
synonym: "beta-glucogallin:1,2,3,6-tetra-O-galloylglucose 4-O-galloyltransferase activity" EXACT [EC:2.3.1.143]
xref: EC:2.3.1.143
xref: KEGG:R04498
xref: MetaCyc:2.3.1.143-RXN
xref: RHEA:19112
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0047177
name: glycerophospholipid arachidonoyl-transferase (CoA-independent) activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-alkyl-2-lyso-sn-glycero-3-phosphoethanolamine + 1-alkyl-2-arachidonyl-sn-glycero-3-phosphocholine = 1-alkyl-2-lyso-sn-glycero-3-phosphocholine + 1-alkyl-2-arachidonyl-sn-glycero-3-phosphoethanolamine." [EC:2.3.1.147, MetaCyc:2.3.1.147-RXN]
synonym: "1-organyl-2-arachidonoyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine arachidonoyltransferase (CoA-independent)" EXACT [EC:2.3.1.147]
synonym: "1-organyl-2-arachidonyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine arachidonoyltransferase (CoA-independent)" EXACT [EC:2.3.1.147]
xref: EC:2.3.1.147
xref: MetaCyc:2.3.1.147-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0047178
name: glycerophospholipid acyltransferase (CoA-dependent) activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-radyl-2-lyso-sn-glycero-3-phosphoethanolamine + 1-radyl-2-acyl-sn-glycero-3-phosphocholine = 1-radyl-2-lyso-sn-glycero-3-phosphocholine + 1-radyl-2-acyl-sn-glycero-3-phosphoethanolamine." [EC:2.3.1.148, MetaCyc:2.3.1.148-RXN]
synonym: "1-organyl-2-acyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine acyltransferase (CoA-dependent)" EXACT [EC:2.3.1.148]
xref: EC:2.3.1.148
xref: MetaCyc:2.3.1.148-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0047179
name: platelet-activating factor acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-radyl-2-acyl-sn-glycero-3-phospholipid + 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine = 1-alkyl-2-lyso-sn-glycero-3-phosphocholine + 1-radyl-2-acetyl-sn-glycero-3-phospholipid." [EC:2.3.1.149, MetaCyc:2.3.1.149-RXN]
synonym: "1-alkyl-2-acyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phospholipid acetyltransferase activity" EXACT [EC:2.3.1.149]
synonym: "PAF acetyltransferase activity" EXACT []
xref: EC:2.3.1.149
xref: MetaCyc:2.3.1.149-RXN
is_a: GO:0016407 ! acetyltransferase activity

[Term]
id: GO:0047180
name: salutaridinol 7-O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (7S)-salutaridinol + acetyl-CoA = (7S)-O-acetylsalutaridinol + CoA." [EC:2.3.1.150, RHEA:22859]
synonym: "acetyl-CoA:salutaridinol 7-O-acetyltransferase activity" EXACT [EC:2.3.1.150]
xref: EC:2.3.1.150
xref: KEGG:R04723
xref: MetaCyc:2.3.1.150-RXN
xref: RHEA:22859
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0047181
name: benzophenone synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxybenzoyl-CoA + 3 malonyl-CoA = 3 CO2 + 2,3',4,6-tetrahydroxybenzophenone + 4 coenzyme A." [EC:2.3.1.151, MetaCyc:2.3.1.151-RXN]
synonym: "malonyl-CoA:3-hydroxybenzoyl-CoA malonyltransferase activity" EXACT [EC:2.3.1.151]
xref: EC:2.3.1.151
xref: MetaCyc:2.3.1.151-RXN
xref: RHEA:19308
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0047182
name: alcohol O-cinnamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: an alcohol + 1-O-trans-cinnamoyl-beta-D-glucopyranose = beta-D-glucose + alkyl cinnamate." [EC:2.3.1.152, MetaCyc:2.3.1.152-RXN]
synonym: "1-O-trans-cinnamoyl-beta-D-glucopyranose:alcohol O-cinnamoyltransferase activity" EXACT [EC:2.3.1.152]
xref: EC:2.3.1.152
xref: MetaCyc:2.3.1.152-RXN
xref: RHEA:23527
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0047183
name: anthocyanin 5-aromatic acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: anthocyanidin-3,5-diglucoside + hydroxycinnamoyl-CoA = anthocyanidin 3-glucoside-5-hydroxycinnamoylglucoside + CoA." [EC:2.3.1.153, MetaCyc:2.3.1.153-RXN]
synonym: "hydroxycinnamoyl-CoA:anthocyanidin 3,5-diglucoside 5-O-glucoside-6'''-O-hydroxycinnamoyltransferase activity" EXACT [EC:2.3.1.153]
xref: EC:2.3.1.153
xref: MetaCyc:RXN-7945
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0047184
name: 1-acylglycerophosphocholine O-acyltransferase activity
namespace: molecular_function
alt_id: GO:0000507
def: "Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine + acyl-CoA = phosphatidylcholine + CoA." [EC:2.3.1.23, MetaCyc:2.3.1.23-RXN]
synonym: "1-acyl-sn-glycero-3-phosphocholine acyltransferase activity" EXACT [EC:2.3.1.23]
synonym: "acyl coenzyme A-monoacylphosphatidylcholine acyltransferase activity" EXACT [EC:2.3.1.23]
synonym: "acyl-CoA:1-acyl-glycero-3-phosphocholine transacylase activity" EXACT [EC:2.3.1.23]
synonym: "acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase activity" EXACT [EC:2.3.1.23]
synonym: "lysolecithin acyltransferase activity" EXACT [EC:2.3.1.23]
synonym: "lysophosphatide acyltransferase activity" EXACT [EC:2.3.1.23]
synonym: "lysophosphatidylcholine acyltransferase activity" EXACT [EC:2.3.1.23]
xref: EC:2.3.1.23
xref: MetaCyc:2.3.1.23-RXN
xref: RHEA:12940
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0047185
name: N-acetylneuraminate 4-O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetylneuraminate + acetyl-CoA = N-acetyl-4-O-acetylneuraminate + CoA." [EC:2.3.1.44, RHEA:18308]
synonym: "acetyl-CoA:N-acetylneuraminate 4-O-acetyltransferase activity" EXACT [EC:2.3.1.44]
synonym: "sialate O-acetyltransferase" BROAD [EC:2.3.1.44]
xref: EC:2.3.1.44
xref: KEGG:R01806
xref: MetaCyc:2.3.1.44-RXN
xref: RHEA:18308
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0047186
name: N-acetylneuraminate 7-O(or 9-O)-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetylneuraminate + acetyl-CoA = N-acetyl-7-O(or 9-O)-acetylneuraminate + CoA." [EC:2.3.1.45, MetaCyc:2.3.1.45-RXN]
synonym: "acetyl-CoA:N-acetylneuraminate 7-O(or 9-O)-acetyltransferase activity" EXACT [EC:2.3.1.45]
synonym: "acetyl-CoA:N-acetylneuraminate-7- and/or 8-O-acetyltransferase activity" EXACT [EC:2.3.1.45]
synonym: "acetyl-CoA:N-acetylneuraminate-7- or 8-O-acetyltransferase activity" EXACT [EC:2.3.1.45]
synonym: "acetyl-CoA:N-acetylneuraminate-9(7)-O-acetyltransferase activity" EXACT [EC:2.3.1.45]
synonym: "acetyl-CoA:N-acetylneuraminate-9(or 7)-O-acetyltransferase activity" EXACT [EC:2.3.1.45]
synonym: "glycoprotein 7(9)-O-acetyltransferase activity" EXACT [EC:2.3.1.45]
synonym: "N-acetylneuraminate 7(8)-O-acetyltransferase activity" EXACT [EC:2.3.1.45]
synonym: "N-acetylneuraminate 7,8-O-acetyltransferase activity" EXACT [EC:2.3.1.45]
synonym: "N-acetylneuraminate O7-(or O9-)acetyltransferase activity" EXACT [EC:2.3.1.45]
synonym: "sialate O-acetyltransferase" BROAD [EC:2.3.1.45]
xref: EC:2.3.1.45
xref: MetaCyc:2.3.1.45-RXN
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0047187
name: deacetyl-[citrate-(pro-3S)-lyase] S-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: deacetyl-[citrate-oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)-acetate)] + S-acetylphosphopantetheine = [citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)-acetate)] + pantetheine 4'-phosphate." [EC:2.3.1.49, MetaCyc:2.3.1.49-RXN]
synonym: "deacetyl-citrate-(pro-3S)-lyase acetyltransferase activity" EXACT [EC:2.3.1.49]
synonym: "deacetyl-citrate-(pro-3S)-lyase S-acetyltransferase activity" EXACT [EC:2.3.1.49]
synonym: "S-acetyl phosphopantetheine:deacetyl citrate lyase S-acetyltransferase activity" EXACT [EC:2.3.1.49]
synonym: "S-acetylphosphopantetheine:deacetyl-citrate-oxaloacetate-lyase((pro-3S)-CH2COO-rightacetate)S-acetyltransferase activity" EXACT [EC:2.3.1.49]
xref: EC:2.3.1.49
xref: MetaCyc:2.3.1.49-RXN
is_a: GO:0016418 ! S-acetyltransferase activity

[Term]
id: GO:0047188
name: aromatic-hydroxylamine O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-hydroxy-4-aminobiphenyl + N-hydroxy-4-acetylaminonbiphenyl = N-acetoxy-4-aminobiphenyl + N-hydroxy-4-aminobiphenyl." [EC:2.3.1.56, MetaCyc:2.3.1.56-RXN]
synonym: "aromatic hydroxylamine acetyltransferase activity" EXACT [EC:2.3.1.56]
synonym: "arylhydroxamate acyltransferase activity" EXACT [EC:2.3.1.56]
synonym: "arylhydroxamic acid N,O-acetyltransferase activity" EXACT [EC:2.3.1.56]
synonym: "arylhydroxamic acyltransferase activity" EXACT [EC:2.3.1.56]
synonym: "N,O-acetyltransferase activity" EXACT [EC:2.3.1.56]
synonym: "N-hydroxy-2-acetylaminofluorene N-O acyltransferase activity" EXACT [EC:2.3.1.56]
synonym: "N-hydroxy-4-acetylaminobiphenyl:N-hydroxy-4-aminobiphenyl O-acetyltransferase activity" EXACT [EC:2.3.1.56]
xref: EC:2.3.1.56
xref: MetaCyc:2.3.1.56-RXN
xref: RHEA:20328
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0047189
name: 2,3-diaminopropionate N-oxalyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-amino-L-alanine + oxalyl-CoA = N(3)-oxalyl-L-2,3-diaminopropanoate + CoA." [EC:2.3.1.58, RHEA:13468]
synonym: "ODAP synthase activity" EXACT [EC:2.3.1.58]
synonym: "oxalyl-CoA:L-2,3-diaminopropanoate 3-N-oxalyltransferase activity" EXACT [EC:2.3.1.58]
synonym: "oxalyl-CoA:L-2,3-diaminopropanoate N3-oxalyltransferase activity" EXACT [EC:2.3.1.58]
synonym: "oxalyl-CoA:L-alpha,beta-diaminopropionic acid oxalyltransferase activity" EXACT [EC:2.3.1.58]
synonym: "oxalyldiaminopropionate synthase activity" EXACT [EC:2.3.1.58]
synonym: "oxalyldiaminopropionic synthase activity" EXACT [EC:2.3.1.58]
xref: EC:2.3.1.58
xref: KEGG:R04211
xref: MetaCyc:2.3.1.58-RXN
xref: RHEA:13468
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0047190
name: 2-acylglycerophosphocholine O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-acyl-sn-glycero-3-phosphocholine + acyl-CoA = 1,2-diacyl-sn-glycero-3-phosphocholine + CoA." [EC:2.3.1.62, RHEA:10335]
synonym: "2-acylglycerol-3-phosphorylcholine acyltransferase activity" EXACT [EC:2.3.1.62]
synonym: "2-acylglycerophosphocholine acyltransferase activity" EXACT [EC:2.3.1.62]
synonym: "acyl-CoA:2-acyl-sn-glycero-3-phosphocholine O-acyltransferase activity" EXACT [EC:2.3.1.62]
xref: EC:2.3.1.62
xref: KEGG:R01319
xref: MetaCyc:2.3.1.62-RXN
xref: RHEA:10335
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0047191
name: 1-alkylglycerophosphocholine O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-alkyl-sn-glycero-3-phosphocholine + acyl-CoA = 1-alkyl-2-acyl-sn-glycero-3-phosphocholine + CoA." [EC:2.3.1.63, MetaCyc:2.3.1.63-RXN]
synonym: "acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine O-acyltransferase activity" EXACT [EC:2.3.1.63]
xref: EC:2.3.1.63
xref: MetaCyc:2.3.1.63-RXN
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0047192
name: 1-alkylglycerophosphocholine O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA." [EC:2.3.1.67, MetaCyc:2.3.1.67-RXN]
synonym: "1-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase activity" EXACT [EC:2.3.1.67]
synonym: "1-alkyl-2-lysolecithin acetyltransferase activity" EXACT [EC:2.3.1.67]
synonym: "acetyl-CoA:1-alkyl-2-lyso-sn-glycero-3-phosphocholine 2-O-acetyltransferase activity" EXACT [EC:2.3.1.67]
synonym: "acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine 2-O-acetyltransferase activity" EXACT [EC:2.3.1.67]
synonym: "acetyl-CoA:lyso-PAF acetyltransferase activity" EXACT [EC:2.3.1.67]
synonym: "acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine acyltransferase activity" EXACT [EC:2.3.1.67]
synonym: "blood platelet-activating factor acetyltransferase activity" BROAD [EC:2.3.1.67]
synonym: "lyso-GPC:acetyl CoA acetyltransferase activity" BROAD [EC:2.3.1.67]
synonym: "lyso-platelet activating factor:acetyl-CoA acetyltransferase activity" BROAD [EC:2.3.1.67]
synonym: "lyso-platelet-activating factor:acetyl-CoA acetyltransferase activity" BROAD [EC:2.3.1.67]
synonym: "lysoPAF:acetyl CoA acetyltransferase activity" EXACT [EC:2.3.1.67]
synonym: "lysopaf:acetyl CoA acetyltransferase activity" BROAD [EC:2.3.1.67]
synonym: "platelet-activating factor acylhydrolase activity" BROAD [EC:2.3.1.67]
synonym: "platelet-activating factor-synthesizing enzyme activity" BROAD [EC:2.3.1.67]
xref: EC:2.3.1.67
xref: MetaCyc:2.3.1.67-RXN
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0047193
name: obsolete CDP-acylglycerol O-arachidonoyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: CDP-acylglycerol + arachidonyl-CoA = CDP-diacylglycerol + CoA." [EC:2.3.1.70, MetaCyc:2.3.1.70-RXN]
comment: This term was made obsolete because the evidence for the existence of this reaction was retracted. Please see PMID:6885763 for more information.
synonym: "arachidonoyl-CoA:CDP-acylglycerol O-arachidonoyltransferase activity" EXACT [EC:2.3.1.70]
synonym: "arachidonyl-CoA:CDP-acylglycerol O-arachidonyltransferase activity" EXACT [EC:2.3.1.70]
synonym: "CDP-acylglycerol O-arachidonoyltransferase activity" EXACT []
synonym: "CDP-acylglycerol O-arachidonyltransferase activity" EXACT []
synonym: "CDPacylglycerol O-arachidonyltransferase activity" EXACT [EC:2.3.1.70]
xref: EC:2.3.1.70
xref: MetaCyc:2.3.1.70-RXN
is_obsolete: true

[Term]
id: GO:0047194
name: indoleacetylglucose-inositol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-O-(indol-3-ylacetyl)-beta-D-glucose + myo-inositol = 1L-1-O-(indol-3-yl)acetyl-myo-inositol + D-glucose." [EC:2.3.1.72, RHEA:21183]
synonym: "1-O-(indol-3-yl)acetyl-beta-D-glucose:myo-inositol (indol-3-yl)acetyltransferase activity" EXACT [EC:2.3.1.72]
synonym: "1-O-(indol-3-ylacetyl)-beta-D-glucose:myo-inositol indole-3-ylacetyltransferase activity" EXACT [EC:2.3.1.72]
synonym: "indole-3-acetyl-beta-1-D-glucoside:myo-inositol indoleacetyltransferase activity" EXACT [EC:2.3.1.72]
xref: EC:2.3.1.72
xref: KEGG:R04333
xref: MetaCyc:2.3.1.72-RXN
xref: RHEA:21183
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0047195
name: diacylglycerol-sterol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: sterol + 1,2-diacylglycerol = sterol ester + acylglycerol." [EC:2.3.1.73, MetaCyc:2.3.1.73-RXN]
synonym: "1,2-diacyl-sn-glycerol:sterol acyl transferase activity" EXACT [EC:2.3.1.73]
synonym: "1,2-diacyl-sn-glycerol:sterol O-acyltransferase activity" EXACT [EC:2.3.1.73]
xref: EC:2.3.1.73
xref: MetaCyc:2.3.1.73-RXN
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0047196
name: long-chain-alcohol O-fatty-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a long-chain-alcohol + acyl-CoA = a long-chain ester + CoA." [EC:2.3.1.75, MetaCyc:2.3.1.75-RXN]
synonym: "acyl-CoA:long-chain-alcohol O-acyltransferase activity" EXACT [EC:2.3.1.75]
synonym: "wax synthase activity" RELATED [EC:2.3.1.75]
synonym: "wax-ester synthase activity" EXACT [EC:2.3.1.75]
xref: EC:2.3.1.75
xref: MetaCyc:2.3.1.75-RXN
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0047197
name: triglyceride-sterol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 3-beta-hydroxysterol + triacylglycerol = a 3-beta-hydroxysterol ester + 1,2-diacylglycerol." [EC:2.3.1.77, MetaCyc:2.3.1.77-RXN]
synonym: "triacylglycerol-sterol O-acyltransferase activity" EXACT [GOC:curators]
synonym: "triacylglycerol:3beta-hydroxysterol O-acyltransferase activity" EXACT [EC:2.3.1.77]
synonym: "triacylglycerol:sterol acyltransferase activity" EXACT [EC:2.3.1.77]
xref: EC:2.3.1.77
xref: MetaCyc:2.3.1.77-RXN
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0047198
name: cysteine-S-conjugate N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-substituted L-cysteine + acetyl-CoA = S-substituted N-acetyl-L-cysteine + CoA + H(+)." [EC:2.3.1.80, RHEA:19216]
synonym: "acetyl-CoA:S-substituted L-cysteine N-acetyltransferase activity" EXACT [EC:2.3.1.80]
xref: EC:2.3.1.80
xref: KEGG:R04950
xref: MetaCyc:2.3.1.80-RXN
xref: RHEA:19216
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0047199
name: phosphatidylcholine-dolichol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-diacyl-sn-glycero-3-phosphocholine + dolichol = 1-acyl-sn-glycero-3-phosphocholine + acyldolichol." [EC:2.3.1.83, RHEA:19288]
synonym: "3-sn-phosphatidylcholine:dolichol O-acyltransferase activity" EXACT [EC:2.3.1.83]
xref: EC:2.3.1.83
xref: KEGG:R04227
xref: MetaCyc:2.3.1.83-RXN
xref: RHEA:19288
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0047200
name: tetrahydrodipicolinate N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA + H(2)O = L-2-acetamido-6-oxopimelate + CoA." [EC:2.3.1.89, RHEA:13088]
subset: gosubset_prok
synonym: "acetyl-CoA:(S)-2,3,4,5-tetrahydrodipicolinate-2,6-dicarboxylate N2-acetyltransferase activity" EXACT [EC:2.3.1.89]
synonym: "acetyl-CoA:(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate 2-N-acetyltransferase activity" EXACT [EC:2.3.1.89]
synonym: "acetyl-CoA:L-2,3,4,5-tetrahydrodipicolinate N2-acetyltransferase activity" EXACT [EC:2.3.1.89]
synonym: "tetrahydrodipicolinate acetylase activity" EXACT [EC:2.3.1.89]
synonym: "tetrahydrodipicolinate:acetyl-CoA acetyltransferase activity" EXACT [EC:2.3.1.89]
xref: EC:2.3.1.89
xref: KEGG:R04364
xref: MetaCyc:2.3.1.89-RXN
xref: RHEA:13088
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0047201
name: beta-glucogallin O-galloyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 1-O-galloyl-beta-D-glucose = 1,6-bis-O-galloyl-beta-D-glucose + D-glucose." [EC:2.3.1.90, RHEA:11419]
synonym: "1-O-galloyl-beta-D-glucose:1-O-galloyl-beta-D-glucose O-galloyltransferase activity" EXACT [EC:2.3.1.90]
xref: EC:2.3.1.90
xref: KEGG:R00049
xref: MetaCyc:2.3.1.90-RXN
xref: RHEA:11419
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0047202
name: sinapoylglucose-choline O-sinapoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-O-sinapoyl-beta-D-glucose + choline = O-sinapoylcholine + D-glucose." [EC:2.3.1.91, RHEA:12027]
synonym: "1-O-(4-hydroxy-3,5-dimethoxycinnamoyl)-beta-D-glucose:choline 1-O-(4-hydroxy-3,5-dimethoxycinnamoyl)transferase activity" EXACT [EC:2.3.1.91]
synonym: "sinapine synthase activity" EXACT [EC:2.3.1.91]
xref: EC:2.3.1.91
xref: KEGG:R03075
xref: MetaCyc:2.3.1.91-RXN
xref: RHEA:12027
is_a: GO:0016753 ! O-sinapoyltransferase activity

[Term]
id: GO:0047203
name: 13-hydroxylupinine O-tigloyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 13-hydroxylupanine + 2-methylcrotonoyl-CoA = 13-(2-methylcrotonoyloxy)lupanine + CoA." [EC:2.3.1.93, RHEA:12363]
synonym: "(E)-2-methylcrotonoyl-CoA:13-hydroxylupinine O-2-methylcrotonoyltransferase activity" EXACT [EC:2.3.1.93]
synonym: "13-hydroxylupanine acyltransferase activity" EXACT [EC:2.3.1.93]
synonym: "tigloyl-CoA:13-hydroxylupanine O-tigloyltransferase activity" EXACT [EC:2.3.1.93]
xref: EC:2.3.1.93
xref: KEGG:R04205
xref: MetaCyc:2.3.1.93-RXN
xref: RHEA:12363
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0047204
name: chlorogenate-glucarate O-hydroxycinnamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucarate + chlorogenate = (-)-quinate + 2-O-caffeoylglucarate." [EC:2.3.1.98, RHEA:23207]
synonym: "chlorogenate:glucarate caffeoyltransferase activity" EXACT [EC:2.3.1.98]
synonym: "chlorogenate:glucarate O-(hydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.98]
synonym: "chlorogenic acid:glucaric acid O-caffeoyltransferase activity" EXACT [EC:2.3.1.98]
xref: EC:2.3.1.98
xref: KEGG:R02998
xref: MetaCyc:2.3.1.98-RXN
xref: RHEA:23207
is_a: GO:0050737 ! O-hydroxycinnamoyltransferase activity

[Term]
id: GO:0047205
name: quinate O-hydroxycinnamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: feruloyl-CoA + quinate = O-feruloylquinate + CoA." [EC:2.3.1.99, MetaCyc:2.3.1.99-RXN]
synonym: "feruloyl-CoA:quinate O-(hydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.99]
synonym: "hydroxycinnamoyl coenzyme A-quinate transferase activity" EXACT [EC:2.3.1.99]
xref: EC:2.3.1.99
xref: MetaCyc:2.3.1.99-RXN
xref: RHEA:15024
is_a: GO:0050737 ! O-hydroxycinnamoyltransferase activity

[Term]
id: GO:0047206
name: UDP-N-acetylmuramoylpentapeptide-lysine N6-alanyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + L-alanyl-tRNA = UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-N6-(L-alanyl)-L-lysyl-D-alanyl-D-alanine + tRNA." [EC:2.3.2.10, MetaCyc:2.3.2.10-RXN]
synonym: "alanyl-transfer ribonucleate-uridine diphosphoacetylmuramoylpentapeptide transferase activity" EXACT [EC:2.3.2.10]
synonym: "L-alanyl-tRNA:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine 6-N-alanyltransferase activity" EXACT [EC:2.3.2.10]
synonym: "L-alanyl-tRNA:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine N6-alanyltransferase activity" EXACT [EC:2.3.2.10]
synonym: "UDP-N-acetylmuramoylpentapeptide lysine N(6)-alanyltransferase activity" EXACT [EC:2.3.2.10]
synonym: "UDP-N-acetylmuramoylpentapeptide lysine N6-alanyltransferase activity" EXACT [EC:2.3.2.10]
synonym: "uridine diphosphoacetylmuramoylpentapeptide lysine N(6)-alanyltransferase activity" EXACT [EC:2.3.2.10]
synonym: "uridine diphosphoacetylmuramoylpentapeptide lysine N6-alanyltransferase activity" EXACT [EC:2.3.2.10]
xref: EC:2.3.2.10
xref: MetaCyc:2.3.2.10-RXN
xref: RHEA:12435
is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups

[Term]
id: GO:0047207
name: 1,2-beta-fructan 1F-fructosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: [(1->2)-beta-D-fructosyl](n) + [(1->2)-beta-D-fructosyl](m) = [(1->2)-beta-D-fructosyl](n+1) + [(1->2)-beta-D-fructosyl](m-1)." [EC:2.4.1.100, MetaCyc:2.4.1.100-RXN]
synonym: "1,2-beta-D-fructan 1(F)-fructosyltransferase activity" EXACT [EC:2.4.1.100]
synonym: "1,2-beta-D-fructan 1F-fructosyltransferase activity" EXACT [EC:2.4.1.100]
synonym: "1,2-beta-D-fructan:1,2-beta-D-fructan 1(F)-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.100]
synonym: "1,2-beta-D-fructan:1,2-beta-D-fructan 1F-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.100]
synonym: "1,2-beta-fructan 1(F)-fructosyltransferase activity" EXACT [EC:2.4.1.100]
synonym: "2,1-beta-D-fructan:2,1-beta-D-fructan 1-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.100]
synonym: "2,1-fructan:2,1-fructan 1-fructosyltransferase activity" EXACT [EC:2.4.1.100]
synonym: "FFT activity" EXACT [EC:2.4.1.100]
synonym: "fructan:fructan fructosyl transferase activity" EXACT [EC:2.4.1.100]
xref: EC:2.4.1.100
xref: MetaCyc:2.4.1.100-RXN
is_a: GO:0050738 ! fructosyltransferase activity

[Term]
id: GO:0047208
name: o-dihydroxycoumarin 7-O-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7,8-dihydroxycoumarin + UDP-D-glucose = daphnin + H(+) + UDP." [EC:2.4.1.104, RHEA:14328]
synonym: "UDP-glucose:7,8-dihydroxycoumarin 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.104]
synonym: "UDP-glucose:o-dihydroxycoumarin glucosyltransferase activity" EXACT [EC:2.4.1.104]
synonym: "UDPglucose:7,8-dihydroxycoumarin 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.104]
synonym: "uridine diphosphoglucose-o-dihydroxycoumarin 7-O-glucosyltransferase activity" EXACT [EC:2.4.1.104]
xref: EC:2.4.1.104
xref: KEGG:R03548
xref: MetaCyc:2.4.1.104-RXN
xref: RHEA:14328
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047209
name: coniferyl-alcohol glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: coniferyl alcohol + UDP-D-glucose = coniferin + UDP." [EC:2.4.1.111, MetaCyc:2.4.1.111-RXN]
synonym: "UDP-glucose coniferyl alcohol glucosyltransferase activity" EXACT [EC:2.4.1.111]
synonym: "UDP-glucose:coniferyl-alcohol 4'-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.111]
synonym: "UDPglucose:coniferyl-alcohol 4'-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.111]
synonym: "uridine diphosphoglucose-coniferyl alcohol glucosyltransferase activity" EXACT [EC:2.4.1.111]
xref: EC:2.4.1.111
xref: MetaCyc:2.4.1.111-RXN
xref: RHEA:23947
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047211
name: alpha-1,4-glucan-protein synthase (ADP-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: ADP-D-glucose + protein = alpha-D-glucosyl-protein + ADP." [EC:2.4.1.113, MetaCyc:2.4.1.113-RXN]
synonym: "1,4alpha-glucan-protein synthase (ADP-forming) activity" EXACT []
synonym: "adenosine diphosphoglucose-protein glucosyltransferase activity" EXACT [EC:2.4.1.113]
synonym: "ADP-glucose:protein 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.113]
synonym: "ADPglucose:protein 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.113]
synonym: "ADPglucose:protein glucosyltransferase activity" EXACT [EC:2.4.1.113]
xref: EC:2.4.1.113
xref: MetaCyc:2.4.1.113-RXN
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0047212
name: 2-coumarate O-beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-2-coumarate + UDP-D-glucose = trans-beta-D-glucosyl-2-hydroxycinnamate + H(+) + UDP." [EC:2.4.1.114, RHEA:10239]
synonym: "UDP-glucose:trans-2-hydroxycinnamate O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.114]
synonym: "UDPG:o-coumaric acid O-glucosyltransferase activity" EXACT [EC:2.4.1.114]
synonym: "UDPglucose:trans-2-hydroxycinnamate O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.114]
synonym: "uridine diphosphoglucose-o-coumarate glucosyltransferase activity" EXACT [EC:2.4.1.114]
xref: EC:2.4.1.114
xref: KEGG:R03710
xref: MetaCyc:2.4.1.114-RXN
xref: RHEA:10239
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047213
name: anthocyanidin 3-O-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: anthocyanidin + UDP-D-glucose = anthocyanidin-3-O-D-glucoside + UDP." [EC:2.4.1.115, MetaCyc:2.4.1.115-RXN]
synonym: "3-GT activity" EXACT [EC:2.4.1.115]
synonym: "UDP-D-glucose:anthocyanidin 3-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.115]
synonym: "UDP-glucose:anthocyanidin 3-O-D-glucosyltransferase activity" EXACT [EC:2.4.1.115]
synonym: "UDP-glucose:anthocyanidin/flavonol 3-O-glucosyltransferase activity" EXACT [EC:2.4.1.115]
synonym: "UDP-glucose:cyanidin-3-O-glucosyltransferase activity" EXACT [EC:2.4.1.115]
synonym: "uridine diphosphoglucose-anthocyanidin 3-O-glucosyltransferase activity" EXACT [EC:2.4.1.115]
xref: EC:2.4.1.115
xref: MetaCyc:2.4.1.115-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047214
name: cyanidin-3-rhamnosylglucoside 5-O-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyanidin-3-O-D-rhamnosyl-(1,6)-D-glucoside + UDP-D-glucose = cyanidin-3-O-[D-rhamnosyl-(1,6)-D-glucoside]-5-O-D-glucoside + UDP." [EC:2.4.1.116, MetaCyc:2.4.1.116-RXN]
synonym: "cyanidin-3-O-rutinoside 5-O-glucosyltransferase activity" EXACT [EC:2.4.1.116]
synonym: "UDP-glucose:cyanidin-3-O-beta-L-rhamnosyl-(1->6)-beta-D-glucoside 5-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.116]
synonym: "UDP-glucose:cyanidin-3-O-D-rhamnosyl-1,6-D-glucoside 5-O-D-glucosyltransferase activity" EXACT [EC:2.4.1.116]
synonym: "uridine diphosphoglucose-cyanidin 3-rhamnosylglucoside 5-O-glucosyltransferase activity" EXACT [EC:2.4.1.116]
xref: EC:2.4.1.116
xref: MetaCyc:2.4.1.116-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047215
name: indole-3-acetate beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (indol-3-yl)acetate + UDP-D-glucose = 1-O-(indol-3-ylacetyl)-beta-D-glucose + UDP." [EC:2.4.1.121, RHEA:14924]
synonym: "IAA-Glu synthetase activity" EXACT [EC:2.4.1.121]
synonym: "IAA-glucose synthase activity" EXACT [EC:2.4.1.121]
synonym: "IAGlu synthase activity" EXACT [EC:2.4.1.121]
synonym: "indol-3-ylacetylglucose synthase activity" EXACT [EC:2.4.1.121]
synonym: "UDP-glucose:(indol-3-yl)acetate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.121]
synonym: "UDP-glucose:auxin glucosyltransferase activity" BROAD []
synonym: "UDP-glucose:indol-3-acetic acid glucosyltransferase activity" EXACT []
synonym: "UDP-glucose:indol-3-ylacetate glucosyl-transferase activity" EXACT [EC:2.4.1.121]
synonym: "UDP-glucose:indol-3-ylacetate glucosyltransferase activity" EXACT [EC:2.4.1.121]
synonym: "UDPG-indol-3-ylacetyl glucosyl transferase activity" EXACT [EC:2.4.1.121]
synonym: "UDPglucose:indole-3-acetate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.121]
synonym: "uridine diphosphoglucose-indoleacetate glucosyltransferase activity" EXACT [EC:2.4.1.121]
xref: EC:2.4.1.121
xref: KEGG:R03094
xref: MetaCyc:2.4.1.121-RXN
xref: RHEA:14924
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047216
name: inositol 3-alpha-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: myo-inositol + UDP-galactose = O-alpha-D-galactosyl-(1,3)-1D-myo-inositol + UDP." [EC:2.4.1.123, MetaCyc:2.4.1.123-RXN]
synonym: "galactinol synthase activity" EXACT [EC:2.4.1.123]
synonym: "inositol 1-alpha-galactosyltransferase activity" EXACT []
synonym: "UDP-D-galactose:inositol galactosyltransferase activity" EXACT [EC:2.4.1.123]
synonym: "UDP-galactose:myo-inositol 1-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.123]
synonym: "UDP-galactose:myo-inositol 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.123]
synonym: "UDPgalactose:myo-inositol 1-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.123]
synonym: "uridine diphosphogalactose-inositol galactosyltransferase activity" EXACT [EC:2.4.1.123]
xref: EC:2.4.1.123
xref: MetaCyc:2.4.1.123-RXN
xref: RHEA:12467
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0047217
name: sucrose-1,6-alpha-glucan 3(6)-alpha-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: sucrose + 1,6-alpha-D-glucosyl(n) = 1,6-alpha-D-glucosyl(n+1) + fructose." [EC:2.4.1.125, MetaCyc:2.4.1.125-RXN]
synonym: "GTF-S" RELATED [EC:2.4.1.125]
synonym: "sucrose:1,6-, 1,3-alpha-D-glucan 3-alpha- and 6-alpha-D-glucosyltransferase" BROAD [EC:2.4.1.125]
synonym: "sucrose:1,6-alpha-D-glucan 3(6)-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.125]
synonym: "sucrose:1,6-alpha-D-glucan 3-alpha- and 6-alpha-glucosyltransferase activity" EXACT [EC:2.4.1.125]
synonym: "water-soluble-glucan synthase activity" RELATED [EC:2.4.1.125]
xref: EC:2.4.1.125
xref: MetaCyc:2.4.1.125-RXN
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0047218
name: hydroxycinnamate 4-beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-coumarate + UDP-D-glucose = 4-O-beta-D-glucosyl-4-hydroxycinnamate + UDP." [EC:2.4.1.126, MetaCyc:2.4.1.126-RXN]
synonym: "hydroxycinnamoyl glucosyltransferase activity" EXACT [EC:2.4.1.126]
synonym: "UDP-glucose-hydroxycinnamate glucosyltransferase activity" EXACT [EC:2.4.1.126]
synonym: "UDP-glucose:trans-4-hydroxycinnamate 4-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.126]
synonym: "UDPglucose:trans-4-hydroxycinnamate 4-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.126]
synonym: "uridine diphosphoglucose-hydroxycinnamate glucosyltransferase activity" EXACT [EC:2.4.1.126]
xref: EC:2.4.1.126
xref: MetaCyc:2.4.1.126-RXN
xref: RHEA:21639
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047219
name: monoterpenol beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (-)-menthol + UDP-D-glucose = (-)-menthyl beta-D-glucoside + H(+) + UDP." [EC:2.4.1.127, RHEA:11523]
synonym: "UDP-glucose:(-)-menthol O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.127]
synonym: "UDPglucose:(-)-menthol O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.127]
synonym: "UDPglucose:monoterpenol glucosyltransferase activity" EXACT [EC:2.4.1.127]
synonym: "uridine diphosphoglucose-monoterpenol glucosyltransferase activity" EXACT [EC:2.4.1.127]
xref: EC:2.4.1.127
xref: KEGG:R02179
xref: MetaCyc:2.4.1.127-RXN
xref: RHEA:11523
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047220
name: galactosylxylosylprotein 3-beta-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-beta-D-galactosyl-O-beta-D-xylosylprotein + UDP-galactose = 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein + UDP." [EC:2.4.1.134, MetaCyc:2.4.1.134-RXN]
synonym: "galactosyltransferase II activity" RELATED [EC:2.4.1.134]
synonym: "UDP-galactose:4-beta-D-galactosyl-O-beta-D-xylosylprotein 3-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.134]
synonym: "UDPgalactose:4-beta-D-galactosyl-O-beta-D-xylosylprotein 3-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.134]
synonym: "uridine diphosphogalactose-galactosylxylose galactosyltransferase activity" EXACT [EC:2.4.1.134]
xref: EC:2.4.1.134
xref: MetaCyc:2.4.1.134-RXN
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0047221
name: sn-glycerol-3-phosphate 2-alpha-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: sn-glycerol 3-phosphate + UDP-D-galactose = 2-(alpha-D-galactosyl)-sn-glycerol 3-phosphate + H(+) + UDP." [EC:2.4.1.137, RHEA:14288]
synonym: "floridoside phosphate synthase activity" EXACT [EC:2.4.1.137]
synonym: "floridoside phosphate synthetase activity" EXACT [EC:2.4.1.137]
synonym: "floridoside-phosphate synthase activity" EXACT [EC:2.4.1.137]
synonym: "FPS" RELATED [EC:2.4.1.137]
synonym: "UDP-galactose, sn-3-glycerol phosphate:1->2' galactosyltransferase activity" EXACT [EC:2.4.1.137]
synonym: "UDP-galactose:sn-glycerol-3-phosphate 2-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.137]
synonym: "UDP-galactose:sn-glycerol-3-phosphate-2-D-galactosyl transferase activity" EXACT [EC:2.4.1.137]
synonym: "UDPgalactose:sn-glycerol-3-phosphate 2-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.137]
xref: EC:2.4.1.137
xref: KEGG:R00853
xref: MetaCyc:2.4.1.137-RXN
xref: RHEA:14288
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0047222
name: mannotetraose 2-alpha-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,3-alpha-D-mannosyl-1,2-alpha-D-mannosyl-1,2-alpha-D-mannosyl-D-mannose + UDP-N-acetyl-D-glucosamine = 1,3-alpha-D-mannosyl-1,2-(N-acetyl-alpha-D-glucosaminyl-alpha-D-mannosyl)-1,2-alpha-D-mannosyl-D-mannose + UDP." [EC:2.4.1.138, MetaCyc:2.4.1.138-RXN]
synonym: "alpha-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.138]
synonym: "UDP-N-acetyl-D-glucosamine:mannotetraose alpha-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.138]
synonym: "uridine diphosphoacetylglucosamine mannoside alpha1->2-alphacetylglucosaminyltransferase activity" EXACT [EC:2.4.1.138]
xref: EC:2.4.1.138
xref: MetaCyc:2.4.1.138-RXN
xref: RHEA:13708
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0047223
name: beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-D-galactosyl-1,3-(N-acetyl-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R + UDP." [EC:2.4.1.146, MetaCyc:2.4.1.146-RXN]
synonym: "elongation 3-beta-GalNAc-transferase activity" RELATED [EC:2.4.1.146]
synonym: "elongation 3beta-GalNAc-transferase activity" EXACT [EC:2.4.1.146]
synonym: "O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II activity" EXACT [EC:2.4.1.146]
synonym: "UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to -D-galactose of beta-D-galactosyl-1,3-(N-acetyl-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R) beta-1,3-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.146]
synonym: "uridine diphosphoacetylglucosamine-mucin beta(1->3)-acetylglucosaminyltransferase (elongating)" EXACT [EC:2.4.1.146]
xref: EC:2.4.1.146
xref: MetaCyc:2.4.1.146-RXN
xref: RHEA:12227
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0047224
name: acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-D-galactosalaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R + UDP." [EC:2.4.1.147, MetaCyc:2.4.1.147-RXN]
synonym: "core 3-beta-GlcNAc-transferase activity" RELATED [EC:2.4.1.147]
synonym: "core 3beta-GlcNAc-transferase activity" EXACT [EC:2.4.1.147]
synonym: "mucin core 3 beta3-GlcNAc-transferase activity" EXACT [EC:2.4.1.147]
synonym: "O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III activity" EXACT [EC:2.4.1.147]
synonym: "UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosaminyl-R) beta-1,3-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.147]
synonym: "uridine diphosphoacetylglucosamine-mucin beta(1->3)-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.147]
xref: EC:2.4.1.147
xref: MetaCyc:2.4.1.147-RXN
xref: RHEA:14252
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0047225
name: acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-galactosaminyl-R + UDP." [EC:2.4.1.148, MetaCyc:2.4.1.148-RXN]
synonym: "core 4 beta6-GalNAc-transferase activity" EXACT [EC:2.4.1.148]
synonym: "core 6-beta-GalNAc-transferase B activity" RELATED [EC:2.4.1.148]
synonym: "core 6beta-GalNAc-transferase B" RELATED [EC:2.4.1.148]
synonym: "O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV activity" EXACT [EC:2.4.1.148]
synonym: "UDP-N-acetyl-D-glucosamine:O-oligosaccharide-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R) beta-1,6-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.148]
synonym: "uridine diphosphoacetylglucosamine-mucin beta(1->6)-acetylglucosaminyltransferase B" RELATED [EC:2.4.1.148]
xref: EC:2.4.1.148
xref: MetaCyc:2.4.1.148-RXN
xref: RHEA:16552
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0047227
name: indolylacetyl-myo-inositol galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1L-1-O-(indol-3-yl)acetyl-myo-inositol + UDP-D-galactose = 5-O-(indol-3-ylacetyl)-myo-inositol D-galactoside + H(+) + UDP." [EC:2.4.1.156, RHEA:21151]
synonym: "indol-3-ylacetyl-myo-inositol galactoside synthase activity" EXACT [EC:2.4.1.156]
synonym: "UDP-galactose:(indol-3-yl)acetyl-myo-inositol 5-O-D-galactosyltransferase activity" EXACT [EC:2.4.1.156]
synonym: "UDP-galactose:indol-3-ylacetyl-myo-inositol 5-O-D-galactosyltransferase activity" EXACT [EC:2.4.1.156]
synonym: "uridine diphosphogalactose-indolylacetylinositol galactosyltransferase activity" EXACT [EC:2.4.1.156]
xref: EC:2.4.1.156
xref: KEGG:R04334
xref: MetaCyc:2.4.1.156-RXN
xref: RHEA:21151
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0047228
name: 1,2-diacylglycerol 3-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-diacylglycerol + UDP-D-glucose = 3-D-glucosyl-1,2-diacylglycerol + UDP." [EC:2.4.1.157, MetaCyc:2.4.1.157-RXN]
subset: gosubset_prok
synonym: "UDP-glucose-diacylglycerol glucosyltransferase activity" EXACT [EC:2.4.1.157]
synonym: "UDP-glucose:1,2-diacylglycerol 3-D-glucosyltransferase activity" EXACT [EC:2.4.1.157]
synonym: "UDP-glucose:1,2-diacylglycerol glucosyltransferase activity" EXACT [EC:2.4.1.157]
synonym: "UDPglucose:1,2-diacylglycerol 3-D-glucosyltransferase activity" EXACT [EC:2.4.1.157]
synonym: "UDPglucose:diacylglycerol glucosyltransferase activity" EXACT [EC:2.4.1.157]
synonym: "uridine diphosphoglucose-diacylglycerol glucosyltransferase activity" EXACT [EC:2.4.1.157]
xref: EC:2.4.1.157
xref: MetaCyc:2.4.1.157-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047229
name: 13-hydroxydocosanoate 13-beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 13-hydroxydocosanoate + UDP-D-glucose = 13-beta-D-glucosyloxydocosanoate + UDP." [EC:2.4.1.158, MetaCyc:2.4.1.158-RXN]
synonym: "13-glucosyloxydocosanoate 2'-beta-glucosyltransferase activity" EXACT [EC:2.4.1.158]
synonym: "UDP-glucose-13-hydroxydocosanoate glucosyltransferase activity" EXACT [EC:2.4.1.158]
synonym: "UDP-glucose:13-hydroxydocosanoate 13-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.158]
synonym: "UDP-glucose:13-hydroxydocosanoic acid glucosyltransferase activity" EXACT [EC:2.4.1.158]
synonym: "UDPglucose:13-hydroxydocosanoate 13-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.158]
synonym: "uridine diphosphoglucose-hydroxydocosanoate glucosyltransferase activity" EXACT [EC:2.4.1.158]
xref: EC:2.4.1.158
xref: MetaCyc:HYDROXYDOCOSANOATE-TRANS-RXN
xref: RHEA:22319
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047230
name: flavonol-3-O-glucoside L-rhamnosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: flavonol 3-O-D-glucoside + UDP-L-rhamnose = flavonol 3-O-L-rhamnosylglucoside + UDP." [EC:2.4.1.159, MetaCyc:2.4.1.159-RXN]
synonym: "UDP-L-rhamnose:flavonol-3-O-D-glucoside 6''-O-L-rhamnosyltransferase activity" EXACT [EC:2.4.1.159]
synonym: "UDP-rhamnose:flavonol 3-O-glucoside rhamnosyltransferase activity" EXACT [EC:2.4.1.159]
synonym: "uridine diphosphorhamnose-flavonol 3-O-glucoside rhamnosyltransferase activity" EXACT [EC:2.4.1.159]
xref: EC:2.4.1.159
xref: MetaCyc:2.4.1.159-RXN
xref: RHEA:22531
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0047231
name: pyridoxine 5'-O-beta-D-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyridoxine + UDP-D-glucose = 5'-O-beta-D-glucosylpyridoxine + H(+) + UDP." [EC:2.4.1.160, RHEA:20180]
synonym: "UDP-glucose-pyridoxine glucosyltransferase activity" EXACT [EC:2.4.1.160]
synonym: "UDP-glucose:pyridoxine 5'-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.160]
synonym: "UDP-glucose:pyridoxine 5'-O-beta-glucosyltransferase activity" EXACT [EC:2.4.1.160]
synonym: "UDPglucose:pyridoxine 5'-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.160]
synonym: "uridine diphosphoglucose-pyridoxine 5'-beta-glucosyltransferase activity" EXACT [EC:2.4.1.160]
xref: EC:2.4.1.160
xref: KEGG:R01912
xref: MetaCyc:2.4.1.160-RXN
xref: RHEA:20180
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047232
name: galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,6-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + UDP-N-acetyl-D-glucosamine = N-acetyl-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosyceramide + UDP." [EC:2.4.1.164, MetaCyc:2.4.1.164-RXN]
synonym: "UDP-N-acetyl-D-glucosamine:D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide beta-1,6-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.164]
synonym: "uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->6-acetylglucosaminyltransferase" BROAD [EC:2.4.1.164]
xref: EC:2.4.1.164
xref: MetaCyc:2.4.1.164-RXN
xref: RHEA:18028
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0047233
name: N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetylneuraminyl-2,3-alpha-D-galactosyl-1,4-beta-D-glucosylceramide + UDP-N-acetylgalactosamine = N-acetyl-beta-D-galactosaminyl-1,4-(N-acetyl-alpha-neuraminyl-2,3)-beta-D-galactosyl-1,4-beta-D-glucosylceramide + UDP." [EC:2.4.1.165, MetaCyc:2.4.1.165-RXN]
synonym: "UDP-N-acetyl-D-galactosamine:N-acetylneuraminyl-2,3-alpha-D-galactosyl-1,4-beta-D-glucosylceramide beta-1,4-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.165]
synonym: "uridine diphosphoacetylgalactosamine-acetylneuraminyl(alpha2->3)galactosyl(beta1->4)glucosyl beta1->4-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.165]
xref: EC:2.4.1.165
xref: MetaCyc:2.4.1.165-RXN
xref: RHEA:13572
is_a: GO:0008376 ! acetylgalactosaminyltransferase activity

[Term]
id: GO:0047234
name: raffinose-raffinose alpha-galactotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 raffinose = sucrose + 1F-alpha-D-galactosylraffinose." [EC:2.4.1.166, MetaCyc:2.4.1.166-RXN]
subset: gosubset_prok
synonym: "raffinose (raffinose donor) galactosyltransferase activity" EXACT [EC:2.4.1.166]
synonym: "raffinose-raffinose a-galactosyltransferase activity" EXACT []
synonym: "raffinose-raffinose alpha-galactosyltransferase activity" EXACT []
synonym: "raffinose:raffinose alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.166]
synonym: "raffinose:raffinose alpha-galactosyltransferase activity" EXACT [EC:2.4.1.166]
xref: EC:2.4.1.166
xref: MetaCyc:2.4.1.166-RXN
xref: RHEA:14128
is_a: GO:0008378 ! galactosyltransferase activity

[Term]
id: GO:0047235
name: sucrose 6F-alpha-galactotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: sucrose + UDP-galactose = 6F-alpha-D-galactosylsucrose + UDP." [EC:2.4.1.167, MetaCyc:2.4.1.167-RXN]
synonym: "sucrose 6(F)-alpha-galactosyltransferase activity" EXACT []
synonym: "sucrose 6F-alpha-galactosyltransferase activity" EXACT [EC:2.4.1.167]
synonym: "UDP-galactose:sucrose 6F-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.167]
synonym: "UDPgalactose:sucrose 6F-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.167]
synonym: "UDPgalactose:sucrose 6fru-alpha-galactosyltransferase activity" EXACT [EC:2.4.1.167]
synonym: "uridine diphosphogalactose-sucrose 6F-alpha-galactosyltransferase activity" EXACT [EC:2.4.1.167]
xref: EC:2.4.1.167
xref: MetaCyc:2.4.1.167-RXN
xref: RHEA:10091
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0047236
name: methyl-ONN-azoxymethanol beta-D-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: methylazoxymethanol + UDP-D-glucose = H+ + cycasin + UDP." [EC:2.4.1.171, MetaCyc:2.4.1.171-RXN]
synonym: "cycasin synthase activity" EXACT [EC:2.4.1.171]
synonym: "methyl-ONN-azoxymethanol glucosyltransferase activity" EXACT []
synonym: "UDP-glucose:methyl-ONN-azoxymethanol beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.171]
synonym: "UDPglucose-methylazoxymethanol glucosyltransferase activity" EXACT [EC:2.4.1.171]
synonym: "uridine diphosphoglucose-methylazoxymethanol glucosyltransferase activity" EXACT [EC:2.4.1.171]
xref: EC:2.4.1.171
xref: MetaCyc:2.4.1.171-RXN
xref: RHEA:20208
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047237
name: glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucuronyl-1,3-beta-D-galactosylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-1,3-beta-D-galactosylproteoglycan + UDP." [EC:2.4.1.174, MetaCyc:2.4.1.174-RXN]
synonym: "glucuronylgalactosylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity" EXACT []
synonym: "N-acetylgalactosaminyltransferase I activity" EXACT []
synonym: "UDP-N-acetyl-D-galactosamine:D-glucuronyl-1,3-beta-D-galactosyl-proteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.174]
synonym: "uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase I" RELATED [EC:2.4.1.174]
synonym: "uridine diphosphoacetylgalactosamine-chondroitinacetylgalactosaminyltransferase I activity" EXACT [EC:2.4.1.174]
xref: EC:2.4.1.174
xref: MetaCyc:2.4.1.174-RXN
is_a: GO:0008376 ! acetylgalactosaminyltransferase activity

[Term]
id: GO:0047238
name: glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP." [EC:2.4.1.175, MetaCyc:2.4.1.175-RXN]
synonym: "chondroitin synthase activity" EXACT [EC:2.4.1.175]
synonym: "glucuronyl-N-acetylgalactosaminylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity" EXACT []
synonym: "glucuronyl-N-acetylgalactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity" EXACT []
synonym: "N-acetylgalactosaminyltransferase II activity" EXACT []
synonym: "UDP-N-acetyl-D-galactosamine:beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.175]
synonym: "UDP-N-acetyl-D-galactosamine:D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.175]
synonym: "uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase II activity" EXACT [EC:2.4.1.175]
xref: EC:2.4.1.175
xref: MetaCyc:2.4.1.175-RXN
is_a: GO:0008376 ! acetylgalactosaminyltransferase activity

[Term]
id: GO:0047239
name: hydroxymandelonitrile glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxymandelonitrile + UDP-D-glucose = H(+) + taxiphyllin + UDP." [EC:2.4.1.178, RHEA:15964]
synonym: "cyanohydrin glucosyltransferase activity" EXACT [EC:2.4.1.178]
synonym: "UDP-glucose:4-hydroxymandelonitrile glucosyltransferase activity" EXACT [EC:2.4.1.178]
synonym: "UDPglucose:4-hydroxymandelonitrile glucosyltransferase activity" EXACT [EC:2.4.1.178]
xref: EC:2.4.1.178
xref: KEGG:R02709
xref: MetaCyc:2.4.1.178-RXN
xref: RHEA:15964
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047240
name: lactosylceramide beta-1,3-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-galactosyl-(1->4)-beta-D-glucosyl-R + UDP-D-galactose = D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-R + H(+) + UDP." [EC:2.4.1.179, RHEA:18416]
synonym: "UDP-galactose:D-galactosyl-1,4-beta-D-glucosyl-R beta-1,3-galactosyltransferase activity" EXACT [EC:2.4.1.179]
synonym: "UDPgalactose:D-galactosyl-1,4-beta-D-glucosyl-R beta-1,3-galactosyltransferase activity" EXACT [EC:2.4.1.179]
synonym: "uridine diphosphogalactose-lactosylceramide beta1->3-galactosyltransferase activity" EXACT [EC:2.4.1.179]
xref: EC:2.4.1.179
xref: KEGG:R04431
xref: MetaCyc:2.4.1.179-RXN
xref: RHEA:18416
is_a: GO:0035250 ! UDP-galactosyltransferase activity
is_a: GO:0048531 ! beta-1,3-galactosyltransferase activity

[Term]
id: GO:0047241
name: lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: lipopolysaccharide + UDP-N-acetylmannosaminouronate = N-acetyl-beta-D-mannosaminouronosyl-1,4-lipopolysaccharide + UDP." [EC:2.4.1.180, MetaCyc:2.4.1.180-RXN]
synonym: "LPS N-acetylmannosaminouronosyltransferase activity" EXACT []
synonym: "ManNAcA transferase activity" EXACT [EC:2.4.1.180]
synonym: "UDP-N-acetyl-beta-D-mannosaminouronate:lipopolysaccharide N-acetyl-beta-D-mannosaminouronosyltransferase activity" EXACT [EC:2.4.1.180]
synonym: "uridine diphosphoacetylmannosaminuronate-acetylglucosaminylpyrophosphorylundecaprenol acetylmannosaminuronosyltransferase activity" EXACT [EC:2.4.1.180]
xref: EC:2.4.1.180
xref: MetaCyc:2.4.1.180-RXN
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0047242
name: hydroxyanthraquinone glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a hydroxyanthraquinone + UDP-D-glucose = a glucosyloxyanthraquinone + UDP." [EC:2.4.1.181, MetaCyc:2.4.1.181-RXN]
synonym: "anthraquinone-specific glucosyltransferase activity" EXACT [EC:2.4.1.181]
synonym: "UDP-glucose:hydroxyanthraquinone O-glucosyltransferase activity" EXACT [EC:2.4.1.181]
synonym: "UDPglucose:hydroxyanthraquinone O-glucosyltransferase activity" EXACT [EC:2.4.1.181]
synonym: "uridine diphosphoglucose-anthraquinone glucosyltransferase activity" EXACT [EC:2.4.1.181]
xref: EC:2.4.1.181
xref: MetaCyc:2.4.1.181-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047243
name: flavanone 7-O-beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a flavanone + UDP-D-glucose = a flavanone 7-O-beta-D-glucoside + UDP." [EC:2.4.1.185, MetaCyc:2.4.1.185-RXN]
synonym: "hesperetin 7-O-glucosyl-transferase activity" EXACT [EC:2.4.1.185]
synonym: "naringenin 7-O-glucosyltransferase activity" EXACT [EC:2.4.1.185]
synonym: "UDP-glucose:flavanone 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.185]
synonym: "UDPglucose:flavanone 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.185]
synonym: "uridine diphosphoglucose-flavanone 7-O-glucosyltransferase activity" EXACT [EC:2.4.1.185]
xref: EC:2.4.1.185
xref: MetaCyc:2.4.1.185-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047244
name: N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP-N-acetyl-D-mannosamine = N-acetyl-beta-D-mannosaminyl-1,4-N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP." [EC:2.4.1.187, MetaCyc:2.4.1.187-RXN]
subset: gosubset_prok
synonym: "N-acetylmannosaminyltransferase activity" EXACT [EC:2.4.1.187]
synonym: "UDP-N-acetyl-D-mannosamine:N-acetyl-beta-D-glucosaminyldiphosphoundecaprenol beta-1,4-N-acetylmannosaminyltransferase activity" EXACT [EC:2.4.1.187]
synonym: "UDP-N-acetylmannosamine:N-acetylglucosaminyl diphosphorylundecaprenol N-acetylmannosaminyltransferase activity" EXACT [EC:2.4.1.187]
synonym: "uridine diphosphoacetyl-mannosamineacetylglucosaminylpyrophosphorylundecaprenol acetylmannosaminyltransferase activity" EXACT [EC:2.4.1.187]
xref: EC:2.4.1.187
xref: MetaCyc:TEICHOICSYN2-RXN
xref: RHEA:16056
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0047245
name: N-acetylglucosaminyldiphosphoundecaprenol glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP-D-glucose = beta-D-glucosyl-1,4-N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP." [EC:2.4.1.188, MetaCyc:2.4.1.188-RXN]
synonym: "UDP-D-glucose:N-acetylglucosaminyl pyrophosphorylundecaprenol glucosyltransferase activity" EXACT [EC:2.4.1.188]
synonym: "UDP-glucose:N-acetyl-D-glucosaminyldiphosphoundecaprenol 4-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.188]
synonym: "UDPglucose:N-acetyl-D-glucosaminyldiphosphoundecaprenol 4-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.188]
synonym: "uridine diphosphoglucose-acetylglucosaminylpyrophosphorylundecaprenol glucosyltransferase activity" EXACT [EC:2.4.1.188]
xref: EC:2.4.1.188
xref: MetaCyc:2.4.1.188-RXN
xref: RHEA:20955
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047246
name: luteolin-7-O-glucuronide 7-O-glucuronosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: luteolin 7-O-beta-D-glucosiduronate + UDP-alpha-D-glucuronate = H(+) + luteolin 7-O-[(beta-D-glucosiduronate)-(1->2)-(beta-D-glucosiduronate)] + UDP." [EC:2.4.1.190, RHEA:14152]
synonym: "LMT activity" RELATED [EC:2.4.1.190]
synonym: "luteolin-7-O-glucuronide 2''-O-glucuronosyltransferase activity" EXACT [EC:2.4.1.190]
synonym: "UDP-glucuronate:luteolin 7-O-glucuronide-glucuronosyltransferase activity" EXACT [EC:2.4.1.190]
synonym: "UDP-glucuronate:luteolin-7-O-beta-D-glucuronide 2''-O-glucuronosyltransferase activity" EXACT [EC:2.4.1.190]
synonym: "uridine diphosphoglucuronate-luteolin 7-O-glucuronide glucuronosyltransferase activity" EXACT [EC:2.4.1.190]
xref: EC:2.4.1.190
xref: KEGG:R06827
xref: MetaCyc:2.4.1.190-RXN
xref: RHEA:14152
is_a: GO:0015020 ! glucuronosyltransferase activity

[Term]
id: GO:0047247
name: luteolin-7-O-diglucuronide 4'-O-glucuronosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: luteolin 7-O-[(beta-D-glucosiduronate)-(1->2)-(beta-D-glucosiduronate)] + UDP-alpha-D-glucuronate = H(+) + luteolin 7-O-[(beta-D-glucosiduronate)-(1->2)-(beta-D-glucosiduronate)] 4'-O-beta-D-glucosiduronate + UDP." [EC:2.4.1.191, RHEA:22119]
synonym: "LDT" RELATED [EC:2.4.1.191]
synonym: "UDP-glucuronate:luteolin 7-O-diglucuronide-glucuronosyltransferase activity" EXACT [EC:2.4.1.191]
synonym: "UDP-glucuronate:luteolin-7-O-beta-D-diglucuronide 4'-O-glucuronosyltransferase activity" EXACT [EC:2.4.1.191]
synonym: "UDPglucuronate:luteolin 7-O-diglucuronide-4'-O-glucuronosyl-transferase activity" EXACT [EC:2.4.1.191]
synonym: "UDPglucuronate:luteolin-7-O-beta-D-diglucuronide 4'-O-glucuronosyltransferase activity" EXACT [EC:2.4.1.191]
synonym: "uridine diphosphoglucuronate-luteolin 7-O-diglucuronide glucuronosyltransferase activity" EXACT [EC:2.4.1.191]
xref: EC:2.4.1.191
xref: KEGG:R06828
xref: MetaCyc:2.4.1.191-RXN
xref: RHEA:22119
is_a: GO:0015020 ! glucuronosyltransferase activity

[Term]
id: GO:0047248
name: nuatigenin 3-beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: nuatigenin + UDP-D-glucose = H(+) + nuatigenin 3-beta-D-glucopyranoside + UDP." [EC:2.4.1.192, RHEA:19332]
synonym: "nuatigenin 3beta-glucosyltransferase activity" EXACT [EC:2.4.1.192]
synonym: "UDP-glucose:(20S,22S,25S)-22,25-epoxyfurost-5-ene-3beta,26-diol 3-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.192]
synonym: "UDPglucose:(20S,22S,25S)-22,25-epoxyfurost-5-ene-3beta,26-diol 3-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.192]
synonym: "uridine diphosphoglucose-nuatigenin glucosyltransferase activity" EXACT [EC:2.4.1.192]
xref: EC:2.4.1.192
xref: KEGG:R04577
xref: MetaCyc:2.4.1.192-RXN
xref: RHEA:19332
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047249
name: sarsapogenin 3-beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (25S)-5beta-spirostan-3beta-ol + UDP-D-glucose = (25S)-5beta-spirostan-3beta-yl beta-D-glucoside + H(+) + UDP." [EC:2.4.1.193, RHEA:14464]
synonym: "sarsapogenin 3beta-glucosyltransferase activity" EXACT [EC:2.4.1.193]
synonym: "UDP-glucose:(25S)-5beta-spirostan-3beta-ol 3-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.193]
synonym: "UDPglucose:(25S)-5beta-spirostan-3beta-ol 3-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.193]
synonym: "uridine diphosphoglucose-sarsapogenin glucosyltransferase activity" EXACT [EC:2.4.1.193]
xref: EC:2.4.1.193
xref: KEGG:R04359
xref: MetaCyc:2.4.1.193-RXN
xref: RHEA:14464
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047250
name: 4-hydroxybenzoate 4-O-beta-D-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxybenzoate + UDP-D-glucose = 4-(beta-D-glucosyloxy)benzoate + H(+) + UDP." [EC:2.4.1.194, RHEA:15156]
synonym: "HBA glucosyltransferase activity" EXACT [EC:2.4.1.194]
synonym: "p-hydroxybenzoate glucosyltransferase activity" EXACT [EC:2.4.1.194]
synonym: "PHB glucosyltransferase activity" EXACT [EC:2.4.1.194]
synonym: "PHB-O-glucosyltransferase activity" EXACT [EC:2.4.1.194]
synonym: "UDP-glucose:4-(beta-D-glucopyranosyloxy)benzoic acid glucosyltransferase activity" EXACT [EC:2.4.1.194]
synonym: "UDP-glucose:4-hydroxybenzoate 4-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.194]
synonym: "UDPglucose:4-hydroxybenzoate 4-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.194]
synonym: "uridine diphosphoglucose-4-hydroxybenzoate glucosyltransferase activity" EXACT [EC:2.4.1.194]
xref: EC:2.4.1.194
xref: KEGG:R01304
xref: MetaCyc:2.4.1.194-RXN
xref: RHEA:15156
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047251
name: thiohydroximate beta-D-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenylthioacetohydroximate + UDP-D-glucose = desulfoglucotropeolin + UDP." [EC:2.4.1.195, MetaCyc:2.4.1.195-RXN]
synonym: "desulfoglucosinolate-uridine diphosphate glucosyltransferase activity" EXACT [EC:2.4.1.195]
synonym: "N-hydroxythioamide S-beta-glucosyltransferase activity" EXACT [EC:2.4.1.195]
synonym: "thiohydroximate glucosyltransferase activity" EXACT [EC:2.4.1.195]
synonym: "thiohydroximate S-glucosyltransferase activity" EXACT [EC:2.4.1.195]
synonym: "UDP-glucose:N-hydroxy-2-phenylethanethioamide S-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.195]
synonym: "UDP-glucose:thiohydroximate S-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.195]
synonym: "UDPG:thiohydroximate glucosyltransferase activity" EXACT [EC:2.4.1.195]
synonym: "uridine diphosphoglucose-thiohydroximate glucosyltransferase activity" EXACT [EC:2.4.1.195]
xref: EC:2.4.1.195
xref: MetaCyc:2.4.1.195-RXN
xref: RHEA:13760
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047252
name: beta-mannosylphosphodecaprenol-mannooligosaccharide 6-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (1->6)-alpha-D-mannosyloligosaccharide + beta-D-mannosylphosphodecaprenol = (1->6)-alpha-D-mannosyl-(1->6)-alpha-D-mannosyl-oligosaccharide + decaprenol phosphate." [EC:2.4.1.199, MetaCyc:2.4.1.199-RXN]
synonym: "beta-D-mannosylphosphodecaprenol:1,6-alpha-D-mannosyloligosaccharide 1,6-alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.199]
synonym: "mannosylphospholipid-methylmannoside alpha-1,6-mannosyltransferase activity" EXACT [EC:2.4.1.199]
xref: EC:2.4.1.199
xref: MetaCyc:2.4.1.199-RXN
is_a: GO:0000030 ! mannosyltransferase activity

[Term]
id: GO:0047253
name: alpha-1,6-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-beta-D-glucosaminyl-1,6-beta-D-(N-acetyl-B-glucosaminyl-1,2)-beta-D-mannosyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,6-beta-D-(N-acetyl-D-glucosaminyl-1,2-beta)-(N-acetyl-D-glucosaminyl-1,4-beta)-D-mannosyl-R + UDP." [EC:2.4.1.201, MetaCyc:2.4.1.201-RXN]
synonym: "alpha-1,6-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase activity" EXACT []
synonym: "mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyl-transferase activity" EXACT []
synonym: "mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.201]
synonym: "N-acetylglucosaminyltransferase VI activity" RELATED [EC:2.4.1.201]
synonym: "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase VI activity" EXACT [EC:2.4.1.201]
synonym: "UDP-N-acetyl-D-glucosamine:2,6-bis(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.201]
synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta-1->4-acetylglucosaminyltransferase VI" RELATED [EC:2.4.1.201]
synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta-1->4-acetylglucosaminyltransferase VI activity" EXACT [EC:2.4.1.201]
xref: EC:2.4.1.201
xref: MetaCyc:2.4.1.201-RXN
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0047254
name: 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one + UDP-D-glucose = 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucoside + UDP." [EC:2.4.1.202, MetaCyc:2.4.1.202-RXN]
synonym: "UDP-glucose:2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase activity" EXACT [EC:2.4.1.202]
synonym: "UDPglucose:2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase activity" EXACT [EC:2.4.1.202]
synonym: "uridine diphosphoglucose-2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-glucosyltransferase activity" EXACT [EC:2.4.1.202]
xref: EC:2.4.1.202
xref: MetaCyc:2.4.1.202-RXN
xref: RHEA:15544
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047255
name: galactogen 6-beta-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: galactogen + UDP-galactose = 1,6-beta-D-galctosylgalactogen + UDP." [EC:2.4.1.205, MetaCyc:2.4.1.205-RXN]
synonym: "1,6-D-galactosyltransferase activity" EXACT [EC:2.4.1.205]
synonym: "beta-(1,6)-D-galactosyltransferase activity" EXACT [EC:2.4.1.205]
synonym: "galactogen 6beta-galactosyltransferase activity" EXACT [EC:2.4.1.205]
synonym: "UDP-galactose:galactogen beta-1,6-D-galactosyltransferase activity" EXACT [EC:2.4.1.205]
synonym: "UDPgalactose:galactogen beta-1,6-D-galactosyltransferase activity" EXACT [EC:2.4.1.205]
synonym: "uridine diphosphogalactose-galactogen galactosyltransferase activity" EXACT [EC:2.4.1.205]
xref: EC:2.4.1.205
xref: MetaCyc:2.4.1.205-RXN
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0047256
name: lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: cytolipin-H + UDP-N-acetyl-D-glucosamine = N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + UDP." [EC:2.4.1.206, MetaCyc:2.4.1.206-RXN]
synonym: "beta1->3-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.206]
synonym: "LA2 synthase activity" EXACT [EC:2.4.1.206]
synonym: "lactosylceramide beta-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.206]
synonym: "UDP-N-acetyl-D-glucosamine:D-galactosyl-1,4-beta-D-glucosylceramide beta-1,3-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.206]
synonym: "uridine diphosphoacetylglucosamine-lactosylceramide beta-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.206]
xref: EC:2.4.1.206
xref: MetaCyc:2.4.1.206-RXN
xref: RHEA:13908
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0047257
name: diglucosyl diacylglycerol synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-D-glucose = UDP + 1,2-diacyl-3-O-(alpha-D-glucopyranosyl(1,2)-O-alpha-D-glucopyranosyl)-sn-glycerol." [EC:2.4.1.208, MetaCyc:2.4.1.208-RXN]
synonym: "DGlcDAG synthase activity" EXACT [EC:2.4.1.208]
synonym: "diglucosyl diacylglycerol (DGlcDAG) synthase activity" EXACT []
synonym: "MGlcDAG (1->2) glucosyltransferase activity" EXACT [EC:2.4.1.208]
synonym: "monoglucosyl diacylglycerol (1->2) glucosyltransferase activity" EXACT [EC:2.4.1.208]
synonym: "UDP-glucose:1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol (1->2) glucosyltransferase activity" EXACT [EC:2.4.1.208]
xref: EC:2.4.1.208
xref: MetaCyc:2.4.1.208-RXN
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0047258
name: sphingosine beta-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: sphingosine + UDP-D-galactose = H(+) + psychosine + UDP." [EC:2.4.1.23, RHEA:19488]
synonym: "galactosyl-sphingosine transferase activity" EXACT [EC:2.4.1.23]
synonym: "psychosine-UDP galactosyltransferase activity" EXACT [EC:2.4.1.23]
synonym: "psychosine-uridine diphosphate galactosyltransferase activity" EXACT [EC:2.4.1.23]
synonym: "UDP-galactose:sphingosine 1-beta-galactotransferase activity" EXACT [EC:2.4.1.23]
synonym: "UDPgalactose:sphingosine 1-beta-galactotransferase activity" EXACT [EC:2.4.1.23]
synonym: "UDPgalactose:sphingosine O-galactosyl transferase activity" EXACT [EC:2.4.1.23]
synonym: "uridine diphosphogalactose-sphingosine beta-galactosyltransferase activity" EXACT [EC:2.4.1.23]
xref: EC:2.4.1.23
xref: KEGG:R01928
xref: MetaCyc:2.4.1.23-RXN
xref: RHEA:19488
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0047259
name: glucomannan 4-beta-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: glucomannan(n) + GDP-mannose = glucomannan(n+1) + GDP." [EC:2.4.1.32, MetaCyc:2.4.1.32-RXN]
synonym: "GDP-man-beta-mannan mannosyltransferase activity" EXACT [EC:2.4.1.32]
synonym: "GDP-mannose:glucomannan 1,4-beta-D-mannosyltransferase activity" EXACT []
synonym: "glucomannan 4-b-mannosyltransferase activity" EXACT []
synonym: "glucomannan-synthase activity" EXACT []
xref: EC:2.4.1.32
xref: MetaCyc:2.4.1.32-RXN
is_a: GO:0019187 ! beta-1,4-mannosyltransferase activity

[Term]
id: GO:0047260
name: alpha,alpha-trehalose-phosphate synthase (GDP-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-D-glucose + glucose-6-phosphate = alpha,alpha-trehalose 6-phosphate + GDP." [EC:2.4.1.36, MetaCyc:2.4.1.36-RXN]
synonym: "GDP-glucose-glucosephosphate glucosyltransferase activity" EXACT [EC:2.4.1.36]
synonym: "GDP-glucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.36]
synonym: "GDPglucose-glucose-phosphate glucosyltransferase activity" EXACT [EC:2.4.1.36]
synonym: "GDPglucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.36]
synonym: "guanosine diphosphoglucose-glucose phosphate glucosyltransferase activity" EXACT [EC:2.4.1.36]
synonym: "trehalose phosphate synthase (GDP-forming) activity" EXACT [EC:2.4.1.36]
xref: EC:2.4.1.36
xref: MetaCyc:2.4.1.36-RXN
xref: RHEA:14608
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0047261
name: steroid N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: estradiol-17alpha 3-D-glucuronoside + UDP-N-acetyl-alpha-D-glucosamine = 17alpha-(N-acetyl-D-glucosaminyl)-estradiol 3-D-glucuronoside + H(+) + UDP." [EC:2.4.1.39, RHEA:14156]
synonym: "hydroxy steroid acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.39]
synonym: "steroid acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.39]
synonym: "UDP-N-acetyl-D-glucosamine:estradiol-17alpha-3-D-glucuronoside 17alpha-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.39]
synonym: "uridine diphosphoacetylglucosamine-steroid acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.39]
xref: EC:2.4.1.39
xref: KEGG:R04451
xref: MetaCyc:2.4.1.39-RXN
xref: RHEA:14156
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0047262
name: polygalacturonate 4-alpha-galacturonosyltransferase activity
namespace: molecular_function
alt_id: GO:0050375
def: "Catalysis of the reaction: UDP-D-galacturonate + 1,4-alpha-D-galacturonosyl(n) = 1,4-alpha-D-galacturonosyl(n+1) + UDP." [EC:2.4.1.43, MetaCyc:2.4.1.43-RXN]
synonym: "UDP galacturonate-polygalacturonate alpha-galacturonosyltransferase activity" EXACT [EC:2.4.1.43]
synonym: "UDP-D-galacturonate:1,4-alpha-poly-D-galacturonate 4-alpha-D-galacturonosyltransferase activity" EXACT [EC:2.4.1.43]
synonym: "uridine diphosphogalacturonate-polygalacturonate alpha-galacturonosyltransferase activity" EXACT [EC:2.4.1.43]
xref: EC:2.4.1.43
xref: MetaCyc:2.4.1.43-RXN
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0047263
name: N-acylsphingosine galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ceramide + UDP-galactose = D-galactosylceramide + UDP." [EC:2.4.1.47, MetaCyc:2.4.1.47-RXN]
synonym: "UDP galactose-N-acylsphingosine galactosyltransferase activity" EXACT [EC:2.4.1.47]
synonym: "UDP-galactose:N-acylsphingosine D-galactosyltransferase activity" EXACT [EC:2.4.1.47]
synonym: "UDPgalactose:N-acylsphingosine D-galactosyltransferase activity" EXACT [EC:2.4.1.47]
synonym: "uridine diphosphogalactose-acylsphingosine galactosyltransferase activity" EXACT [EC:2.4.1.47]
xref: EC:2.4.1.47
xref: MetaCyc:2.4.1.47-RXN
xref: RHEA:13096
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0047264
name: heteroglycan alpha-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: heteroglycan + GDP-mannose = alpha-D-mannosylheteroglycan + GDP." [EC:2.4.1.48]
synonym: "GDP mannose alpha-mannosyltransferase activity" EXACT [EC:2.4.1.48]
synonym: "GDP-mannose:heteroglycan 2-(or 3-)-alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.48]
synonym: "guanosine diphosphomannose-heteroglycan alpha-mannosyltransferase activity" EXACT [EC:2.4.1.48]
synonym: "heteropolysaccharide alpha-mannosyltransferase activity" EXACT [GOC:curators]
xref: EC:2.4.1.48
is_a: GO:0000030 ! mannosyltransferase activity

[Term]
id: GO:0047265
name: poly(glycerol-phosphate) alpha-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: poly(glycerol phosphate) + UDP-D-glucose = alpha-D-glucosylpoly(glycerol phosphate) + UDP." [EC:2.4.1.52, MetaCyc:2.4.1.52-RXN]
subset: gosubset_prok
synonym: "UDP glucose-poly(glycerol-phosphate) alpha-glucosyltransferase activity" EXACT [EC:2.4.1.52]
synonym: "UDP-glucose:poly(glycerol-phosphate) alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.52]
synonym: "UDPglucose:poly(glycerol-phosphate) alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.52]
synonym: "uridine diphosphoglucose-poly(glycerol-phosphate) alpha-glucosyltransferase activity" EXACT [EC:2.4.1.52]
xref: EC:2.4.1.52
xref: MetaCyc:2.4.1.52-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047266
name: poly(ribitol-phosphate) beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: poly(ribitol phosphate) + UDP-D-glucose = beta-D-glucosylpoly(ribitol phosphate) + UDP." [EC:2.4.1.53, MetaCyc:2.4.1.53-RXN]
synonym: "UDP glucose-poly(ribitol-phosphate) beta-glucosyltransferase activity" EXACT [EC:2.4.1.53]
synonym: "UDP-D-glucose polyribitol phosphate glucosyl transferase activity" EXACT [EC:2.4.1.53]
synonym: "UDP-D-glucose:polyribitol phosphate glucosyl transferase activity" EXACT [EC:2.4.1.53]
synonym: "UDP-glucose:poly(ribitol-phosphate) beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.53]
synonym: "UDPglucose:poly(ribitol-phosphate) beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.53]
synonym: "uridine diphosphoglucose-poly(ribitol-phosphate) beta-glucosyltransferase activity" EXACT [EC:2.4.1.53]
xref: EC:2.4.1.53
xref: MetaCyc:2.4.1.53-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047267
name: undecaprenyl-phosphate mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-mannose + undecaprenyl phosphate = GDP + D-mannosyl-1-phosphoundecaprenol." [EC:2.4.1.54]
synonym: "GDP mannose-undecaprenyl phosphate mannosyltransferase activity" EXACT [EC:2.4.1.54]
synonym: "GDP-D-mannose:lipid phosphate transmannosylase activity" EXACT [EC:2.4.1.54]
synonym: "GDP-mannose:undecaprenyl-phosphate D-mannosyltransferase activity" EXACT [EC:2.4.1.54]
synonym: "guanosine diphosphomannose-undecaprenyl phosphate mannosyltransferase activity" EXACT [EC:2.4.1.54]
xref: EC:2.4.1.54
is_a: GO:0000030 ! mannosyltransferase activity

[Term]
id: GO:0047268
name: galactinol-raffinose galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: raffinose + 1-alpha-D-galactosyl-myo-inositol = stachyose + myo-inositol." [EC:2.4.1.67, MetaCyc:2.4.1.67-RXN]
synonym: "alpha-D-(1->3)-galactosyl-myo-inositol:raffinose galactosyltransferase activity" EXACT [EC:2.4.1.67]
synonym: "stachyose synthetase activity" EXACT [EC:2.4.1.67]
xref: EC:2.4.1.67
xref: MetaCyc:2.4.1.67-RXN
xref: RHEA:20779
is_a: GO:0008378 ! galactosyltransferase activity

[Term]
id: GO:0047269
name: poly(ribitol-phosphate) N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: poly(ribitol phosphate) + UDP-N-acetyl-D-glucosamine = N-acetyl-D-glucosaminyl-poly(ribitol phosphate) + UDP." [EC:2.4.1.70, MetaCyc:2.4.1.70-RXN]
synonym: "UDP acetylglucosamine-poly(ribitol phosphate) acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.70]
synonym: "UDP-N-acetyl-D-glucosamine:poly(ribitol-phosphate) N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.70]
synonym: "uridine diphosphoacetylglucosamine-poly(ribitol phosphate) acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.70]
xref: EC:2.4.1.70
xref: MetaCyc:2.4.1.70-RXN
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0047270
name: lipopolysaccharide glucosyltransferase II activity
namespace: molecular_function
def: "Catalysis of the reaction: lipopolysaccharide + UDP-D-glucose = D-glucosyl-lipopolysaccharide + UDP." [EC:2.4.1.73, GOC:mr, GOC:pr, MetaCyc:2.4.1.73-RXN]
synonym: "LPS glucosyltransferase II activity" EXACT []
synonym: "UDP-glucose:galactosyl-lipopolysaccharide alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.73]
synonym: "UDPglucose:galactosyl-lipopolysaccharide alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.73]
synonym: "uridine diphosphoglucose-galactosylpolysaccharide glucosyltransferase activity" EXACT [EC:2.4.1.73]
xref: EC:2.4.1.73
xref: MetaCyc:2.4.1.73-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity
relationship: part_of GO:0009103 ! lipopolysaccharide biosynthetic process

[Term]
id: GO:0047271
name: glycosaminoglycan galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycosaminoglycan + UDP-galactose = D-galactosylglycosaminoglycan + UDP." [EC:2.4.1.74, MetaCyc:2.4.1.74-RXN]
synonym: "UDP-galactose:glycosaminoglycan D-galactosyltransferase activity" EXACT [EC:2.4.1.74]
synonym: "UDPgalactose:glycosaminoglycan D-galactosyltransferase activity" EXACT [EC:2.4.1.74]
synonym: "uridine diphosphogalactose-mucopolysaccharide galactosyltransferase activity" EXACT [EC:2.4.1.74]
xref: EC:2.4.1.74
xref: MetaCyc:2.4.1.74-RXN
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0047272
name: phosphopolyprenol glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: polyprenyl phosphate + UDP-D-glucose = polyprenylphosphate-glucose + UDP." [EC:2.4.1.78, MetaCyc:2.4.1.78-RXN]
synonym: "UDP-glucose:phosphopolyprenol D-glucosyltransferase activity" EXACT [EC:2.4.1.78]
synonym: "UDPglucose:phosphopolyprenol D-glucosyltransferase activity" EXACT [EC:2.4.1.78]
synonym: "UDPglucose:polyprenol monophosphate glucosyltransferase activity" EXACT [EC:2.4.1.78]
synonym: "uridine diphosphoglucose-polyprenol monophosphate glucosyltransferase activity" EXACT [EC:2.4.1.78]
xref: EC:2.4.1.78
xref: MetaCyc:2.4.1.78-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047273
name: galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity
namespace: molecular_function
alt_id: GO:0047226
def: "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide = UDP + beta-N-acetyl-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide." [EC:2.4.1.79, MetaCyc:2.4.1.79-RXN]
synonym: "beta-3GalNAc-T1 activity" EXACT [EC:2.4.1.79]
synonym: "beta3GalNAc-T1" RELATED [EC:2.4.1.79]
synonym: "galactosylgalactosylglucosylceramide beta-D- activity" EXACT [EC:2.4.1.79]
synonym: "globoside synthase activity" EXACT [EC:2.4.1.79]
synonym: "globoside synthetase activity" EXACT [EC:2.4.1.79]
synonym: "globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.79]
synonym: "globotriosylceramide beta-1,6-N-acetylgalactosaminyltransferase activity" EXACT []
synonym: "UDP-N-acetyl-D-galactosamine:alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide 3III-beta-N-acetyl-D-galactosaminyltransferase activity" EXACT [EC:2.4.1.79]
synonym: "UDP-N-acetyl-D-galactosamine:D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide beta-N-acetyl-D-galactosaminyltransferase activity" EXACT [EC:2.4.1.79]
synonym: "UDP-N-acetylgalactosamine:globotriaosylceramide beta-3-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.79]
synonym: "UDP-N-acetylgalactosamine:globotriaosylceramide beta1,3-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.79]
synonym: "uridine diphosphoacetylgalactosamine-galactosylgalactosylglucosylceramide acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.79]
xref: EC:2.4.1.79
xref: MetaCyc:2.4.1.79-RXN
xref: RHEA:22255
is_a: GO:0008376 ! acetylgalactosaminyltransferase activity

[Term]
id: GO:0047274
name: galactinol-sucrose galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: sucrose + 1-alpha-D-galactosyl-myo-inositol = raffinose + myo-inositol." [EC:2.4.1.82, MetaCyc:2.4.1.82-RXN]
synonym: "1-alpha-D-galactosyl-myo-inositol:sucrose 6-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.82]
synonym: "alpha-D-galactosyl-(1->3)-myo-inositol:sucrose 6-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.82]
synonym: "galactinol:sucrose 6-galactosyl transferase activity" EXACT []
synonym: "galactosyltransferase, galactinol-sucrose" EXACT []
synonym: "raffinose synthase activity" EXACT []
xref: EC:2.4.1.82
xref: MetaCyc:2.4.1.82-RXN
xref: RHEA:20164
is_a: GO:0008378 ! galactosyltransferase activity

[Term]
id: GO:0047275
name: glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-D-glucosaminyl-(1,3)-D-galactosyl-(1,4)-D-glucosylceramide + UDP-galactose = D-galactosyl-N-acetyl-D-glucosaminyl-(1,3)-D-galactosyl-(1,4)-D-glucosylceramide + UDP." [EC:2.4.1.86, MetaCyc:2.4.1.86-RXN]
synonym: "GalT-4" RELATED [EC:2.4.1.86]
synonym: "paragloboside synthase activity" EXACT [EC:2.4.1.86]
synonym: "UDP-galactose:N-acetyl-D-glucosaminyl-1,3-D-galactosyl-1,4-D-glucosylceramide beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.86]
synonym: "UDPgalactose:N-acetyl-D-glucosaminyl-1,3-D-galactosyl-1,4-D-glucosylceramide beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.86]
synonym: "uridine diphosphogalactose-acetyl-glucosaminylgalactosylglucosylceramide galactosyltransferase activity" EXACT [EC:2.4.1.86]
xref: EC:2.4.1.86
xref: MetaCyc:2.4.1.86-RXN
xref: RHEA:16048
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0047276
name: N-acetyllactosaminide 3-alpha-galactosyltransferase activity
namespace: molecular_function
alt_id: GO:0003946
def: "Catalysis of the reaction: beta-D-galactosyl-(1,4)-beta-N-acetyl-D-glucosaminyl-R + UDP-galactose = alpha-D-galactosyl-(1,3)-beta-D-galactosyl-(1,4)-beta-N-acetyl-D-glucosaminyl-R + UDP." [EC:2.4.1.87, MetaCyc:2.4.1.87-RXN]
synonym: "alpha-galactosyltransferase activity" RELATED [EC:2.4.1.87]
synonym: "beta-D-galactosyl-N-acetylglucosaminylglycopeptide alpha-1,3-galactosyltransferase activity" EXACT [EC:2.4.1.87]
synonym: "beta-galactosyl-N-acetylglucosaminylglycopeptide alpha-1,3-galactosyltransferase activity" EXACT []
synonym: "glucosaminylglycopeptide alpha-1,3-galactosyltransferase activity" EXACT [EC:2.4.1.87]
synonym: "N-acetyllactosaminide alpha-1,3-galactosyltransferase activity" EXACT []
synonym: "UDP-Gal:beta-D-Gal(1,4)-D-GlcNAc alpha(1,3)-galactosyltransferase activity" EXACT [EC:2.4.1.87]
synonym: "UDP-Gal:beta-D-Gal(1,4)-D-GlcNAc alpha-(1,3)-galactosyltransferase activity" EXACT [EC:2.4.1.87]
synonym: "UDP-Gal:Gal-beta-1->4GlcNAc-R alpha-1->3-galactosyltransferase activity" EXACT [EC:2.4.1.87]
synonym: "UDP-Gal:Galbeta1->4GlcNAc-R alpha1->3-galactosyltransferase activity" EXACT [EC:2.4.1.87]
synonym: "UDP-Gal:N-acetyllactosaminide alpha(1,3)-galactosyltransferase activity" EXACT [EC:2.4.1.87]
synonym: "UDP-Gal:N-acetyllactosaminide alpha-(1,3)-galactosyltransferase activity" EXACT [EC:2.4.1.87]
synonym: "UDP-Gal:N-acetyllactosaminide alpha-1,3-D-galactosyltransferase activity" EXACT [EC:2.4.1.87]
synonym: "UDP-galactose-acetyllactosamine alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.87]
synonym: "UDP-galactose:N-acetyllactosaminide 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.87]
synonym: "UDPgalactose:beta-D-galactosyl-beta-1,4-N-acetyl-D-glucosaminyl-glycopeptide alpha-1,3-D-galactosyltransferase activity" EXACT [EC:2.4.1.87]
synonym: "uridine diphosphogalactose-acetyllactosamine alpha-1->3-galactosyltransferase activity" EXACT [EC:2.4.1.87]
synonym: "uridine diphosphogalactose-acetyllactosamine alpha1->3-galactosyltransferase activity" EXACT [EC:2.4.1.87]
synonym: "uridine diphosphogalactose-acetyllactosamine galactosyltransferase activity" EXACT [EC:2.4.1.87]
synonym: "uridine diphosphogalactose-galactosylacetylglucosaminylgalactosyl-glucosylceramide galactosyltransferase activity" EXACT [EC:2.4.1.87]
synonym: "uridine diphosphogalactose-galactosylacetylglucosaminylgalactosylglucosylceramide galactosyltransferase activity" EXACT [EC:2.4.1.87]
xref: EC:2.4.1.87
xref: MetaCyc:2.4.1.151-RXN
xref: RHEA:13016
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0047277
name: globoside alpha-N-acetylgalactosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-D-galactosaminyl-(1,3)-D-galactosyl-(1,4)-D-galactosyl-(1,4)-D-glucosylceramide + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-N-acetyl-D-galactosaminyl-(1,3)-D-galactosyl-(1,4)-D-galactosyl-(1,4)-D-glucosylceramide + UDP." [EC:2.4.1.88, MetaCyc:2.4.1.88-RXN]
synonym: "Forssman synthase activity" RELATED [EC:2.4.1.88]
synonym: "forssman synthase activity" EXACT [EC:2.4.1.88]
synonym: "globoside acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.88]
synonym: "UDP-N-acetyl-D-galactosamine:N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide alpha-N-acetyl-D-galactosaminyltransferase activity" EXACT [EC:2.4.1.88]
synonym: "uridine diphosphoacetylgalactosamine-globoside alpha-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.88]
xref: EC:2.4.1.88
xref: MetaCyc:2.4.1.88-RXN
xref: RHEA:22167
is_a: GO:0008376 ! acetylgalactosaminyltransferase activity

[Term]
id: GO:0047278
name: bilirubin-glucuronoside glucuronosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 bilirubin-glucuronoside = bilirubin + bilirubin-bisglucuronoside." [EC:2.4.1.95, RHEA:16888]
synonym: "bilirubin glucuronoside glucuronosyltransferase activity" EXACT [EC:2.4.1.95]
synonym: "bilirubin monoglucuronide transglucuronidase activity" EXACT [EC:2.4.1.95]
synonym: "bilirubin-glucuronoside:bilirubin-glucuronoside D-glucuronosyltransferase activity" EXACT [EC:2.4.1.95]
xref: EC:2.4.1.95
xref: KEGG:R00062
xref: MetaCyc:2.4.1.95-RXN
xref: RHEA:16888
is_a: GO:0015020 ! glucuronosyltransferase activity

[Term]
id: GO:0047279
name: sn-glycerol-3-phosphate 1-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: sn-glycerol 3-phosphate + UDP-D-galactose = 1-O-alpha-D-galactosyl-sn-glycerol 3-phosphate + H(+) + UDP." [EC:2.4.1.96, RHEA:20344]
synonym: "glycerol 3-phosphate 1alpha-galactosyltransferase activity" EXACT [EC:2.4.1.96]
synonym: "isofloridoside-phosphate synthase activity" EXACT [EC:2.4.1.96]
synonym: "UDP-Gal:sn-glycero-3-phosphoric acid 1-alpha-galactosyl-transferase activity" EXACT [EC:2.4.1.96]
synonym: "UDP-galactose:sn-glycerol-3-phosphate 1-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.96]
synonym: "UDPgalactose:sn-glycerol-3-phosphate 1-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.96]
synonym: "UDPgalactose:sn-glycerol-3-phosphate alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.96]
synonym: "uridine diphosphogalactose-glycerol phosphate galactosyltransferase activity" EXACT [EC:2.4.1.96]
xref: EC:2.4.1.96
xref: KEGG:R00854
xref: MetaCyc:2.4.1.96-RXN
xref: RHEA:20344
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0047280
name: nicotinamide phosphoribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: diphosphate + nicotinamide mononucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinamide." [EC:2.4.2.12, RHEA:16152]
synonym: "nicotinamide mononucleotide pyrophosphorylase activity" EXACT [EC:2.4.2.12]
synonym: "nicotinamide mononucleotide synthetase activity" EXACT [EC:2.4.2.12]
synonym: "nicotinamide-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.12]
synonym: "NMN diphosphorylase activity" EXACT [EC:2.4.2.12]
synonym: "NMN pyrophosphorylase activity" EXACT [EC:2.4.2.12]
synonym: "NMN synthetase activity" EXACT [EC:2.4.2.12]
xref: EC:2.4.2.12
xref: KEGG:R01271
xref: MetaCyc:2.4.2.12-RXN
xref: Reactome:REACT_102927 "Condensation of nicotinamide to nicotinamide D-ribonucleotide (NMN), Danio rerio"
xref: Reactome:REACT_109246 "Condensation of nicotinamide to nicotinamide D-ribonucleotide (NMN), Rattus norvegicus"
xref: Reactome:REACT_11225 "Condensation of nicotinamide to nicotinamide D-ribonucleotide (NMN), Homo sapiens"
xref: Reactome:REACT_30792 "Condensation of nicotinamide to nicotinamide D-ribonucleotide (NMN), Taeniopygia guttata"
xref: Reactome:REACT_32858 "Condensation of nicotinamide to nicotinamide D-ribonucleotide (NMN), Mus musculus"
xref: Reactome:REACT_79970 "Condensation of nicotinamide to nicotinamide D-ribonucleotide (NMN), Bos taurus"
xref: Reactome:REACT_89766 "Condensation of nicotinamide to nicotinamide D-ribonucleotide (NMN), Canis familiaris"
xref: Reactome:REACT_91270 "Condensation of nicotinamide to nicotinamide D-ribonucleotide (NMN), Gallus gallus"
xref: Reactome:REACT_96040 "Condensation of nicotinamide to nicotinamide D-ribonucleotide (NMN), Sus scrofa"
xref: Reactome:REACT_99287 "Condensation of nicotinamide to nicotinamide D-ribonucleotide (NMN), Xenopus tropicalis"
xref: RHEA:16152
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0047281
name: dioxotetrahydropyrimidine phosphoribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyrophosphate + a 2,4-dioxotetrahydropyrimidine D-ribonucleotide = PRPP + a 2,4-dioxotetrahydropyrimidine." [EC:2.4.2.20, MetaCyc:2.4.2.20-RXN]
synonym: "2,4-dioxotetrahydropyrimidine-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.20]
synonym: "dioxotetrahydropyrimidine phosphoribosyl transferase activity" EXACT [EC:2.4.2.20]
synonym: "dioxotetrahydropyrimidine ribonucleotide pyrophosphorylase activity" EXACT [EC:2.4.2.20]
synonym: "dioxotetrahydropyrimidine-ribonucleotide diphosphorylase activity" EXACT [EC:2.4.2.20]
synonym: "dioxotetrahydropyrimidine-ribonucleotide pyrophosphorylase activity" EXACT [EC:2.4.2.20]
xref: EC:2.4.2.20
xref: MetaCyc:2.4.2.20-RXN
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0047282
name: dTDP-dihydrostreptose-streptidine-6-phosphate dihydrostreptosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: dTDP-L-dihydrostreptose + streptidine 6-phosphate = O-(1->4)-alpha-L-dihydrostreptosyl-streptidine 6-phosphate + dTDP + H(+)." [EC:2.4.2.27, RHEA:24395]
subset: gosubset_prok
synonym: "dTDP-L-dihydrostreptose:streptidine-6-phosphate dihydrostreptosyltransferase activity" EXACT [EC:2.4.2.27]
synonym: "dTDPdihydrostreptose-streptidine-6-phosphate dihydrostreptosyltransferase activity" EXACT [EC:2.4.2.27]
synonym: "thymidine diphosphodihydrostreptose-streptidine 6-phosphate dihydrostreptosyltransferase activity" EXACT [EC:2.4.2.27]
xref: EC:2.4.2.27
xref: KEGG:R04222
xref: MetaCyc:2.4.2.27-RXN
xref: RHEA:24395
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0047283
name: dolichyl-phosphate D-xylosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: dolichol-phosphate + UDP-D-xylose = dolichyl D-xylosyl phosphate + UDP." [EC:2.4.2.32, MetaCyc:2.4.2.32-RXN]
synonym: "UDP-D-xylose:dolichyl-phosphate D-xylosyltransferase activity" EXACT [EC:2.4.2.32]
xref: EC:2.4.2.32
xref: MetaCyc:2.4.2.32-RXN
xref: RHEA:15364
is_a: GO:0035252 ! UDP-xylosyltransferase activity

[Term]
id: GO:0047284
name: dolichyl-xylosyl-phosphate-protein xylosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: dolichyl D-xylosyl phosphate + protein = dolichol-phosphate + D-xylosylprotein." [EC:2.4.2.33, MetaCyc:2.4.2.33-RXN]
synonym: "dolichyl-D-xylosyl-phosphate:protein D-xylosyltransferase activity" EXACT [EC:2.4.2.33]
xref: EC:2.4.2.33
xref: MetaCyc:2.4.2.33-RXN
is_a: GO:0042285 ! xylosyltransferase activity

[Term]
id: GO:0047285
name: flavonol-3-O-glycoside xylosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: flavonol 3-O-glycoside + UDP-D-xylose = flavonol 3-O-D-xylosylglycoside + UDP." [EC:2.4.2.35, MetaCyc:2.4.2.35-RXN]
synonym: "UDP-D-xylose:flavonol-3-O-glycoside 2''-O-beta-D-xylosyltransferase activity" EXACT [EC:2.4.2.35]
xref: EC:2.4.2.35
xref: MetaCyc:2.4.2.35-RXN
xref: RHEA:19704
is_a: GO:0035252 ! UDP-xylosyltransferase activity

[Term]
id: GO:0047286
name: NAD+-diphthamide ADP-ribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: peptide diphthamide + NAD+ = peptide N-(ADP-D-ribosyl)diphthamide + niacinamide." [EC:2.4.2.36]
subset: gosubset_prok
synonym: "ADP-ribosyltransferase activity" BROAD [EC:2.4.2.36]
synonym: "mono(ADP-ribosyl)transferase activity" BROAD [EC:2.4.2.36]
synonym: "NAD+:peptide-diphthamide N-(ADP-D-ribosyl)transferase activity" EXACT [EC:2.4.2.36]
synonym: "NAD-diphthamide ADP-ribosyltransferase activity" EXACT []
xref: EC:2.4.2.36
xref: MetaCyc:RXN-11372
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0047287
name: lactosylceramide alpha-2,6-N-sialyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: cytolipin-H + CMP-N-acetylneuraminate = alpha-N-acetylneuraminyl-2,6-beta-galactosyl-1,4-beta-D-glucosylceramide + CMP." [EC:2.4.99.11, MetaCyc:2.4.99.11-RXN]
synonym: "CMP-acetylneuraminate-lactosylceramide-sialyltransferase" BROAD [EC:2.4.99.11]
synonym: "CMP-N-acetylneuraminate:lactosylceramide alpha-2,6-N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.11]
synonym: "CMP-N-acetylneuraminic acid:lactosylceramide sialyltransferase activity" EXACT [EC:2.4.99.11]
synonym: "CMP-sialic acid:lactosylceramide sialyltransferase activity" EXACT [EC:2.4.99.11]
synonym: "cytidine monophosphoacetylneuraminate-lactosylceramide sialyltransferase" BROAD [EC:2.4.99.11]
xref: EC:2.4.99.11
xref: MetaCyc:2.4.99.11-RXN
xref: RHEA:21555
is_a: GO:0008373 ! sialyltransferase activity

[Term]
id: GO:0047288
name: monosialoganglioside sialyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide + CMP-N-acetylneuraminate = N-acetylneuraminyl-D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide + CMP." [EC:2.4.99.2, MetaCyc:2.4.99.2-RXN]
synonym: "CMP-N-acetylneuraminate:D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.2]
xref: EC:2.4.99.2
xref: MetaCyc:2.4.99.2-RXN
xref: RHEA:18024
is_a: GO:0008373 ! sialyltransferase activity

[Term]
id: GO:0047289
name: galactosyldiacylglycerol alpha-2,3-sialyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + CMP-N-acetyl-beta-neuraminate = 1,2-diacyl-3-[3-(alpha-D-N-acetylneuraminyl)-beta-D-galactosyl]-sn-glycerol + CMP + H(+)." [EC:2.4.99.5, RHEA:11667]
synonym: "CMP-N-acetylneuraminate:1,2-diacyl-3-beta-D-galactosyl-sn-glycerol N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.5]
xref: EC:2.4.99.5
xref: KEGG:R03468
xref: MetaCyc:2.4.99.5-RXN
xref: RHEA:11667
is_a: GO:0008373 ! sialyltransferase activity

[Term]
id: GO:0047290
name: (alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R + CMP-N-acetyl-beta-neuraminate = alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-D-galactosaminyl-R + CMP." [EC:2.4.99.7, RHEA:10479]
synonym: "(alpha-N-acetylneuraminyl-2,3-alpha-galactosyl-1,3)-N-acetyl-galactosaminide alpha-2,6-sialyltransferase activity" EXACT [EC:2.4.99.7]
synonym: "(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity" EXACT []
synonym: "alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase activity" EXACT [EC:2.4.99.7]
synonym: "CMP-N-acetylneuraminate:(alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3)-N-acetyl-D-galactosaminide alpha-2,6-N-acetylneuraminyl-transferase activity" EXACT [EC:2.4.99.7]
synonym: "cytidine monophosphoacetylneuraminate-(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide-alpha-2,6-sialyltransferase activity" EXACT [EC:2.4.99.7]
synonym: "NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc-alpha-2,6-sialyltransferase activity" EXACT [EC:2.4.99.7]
synonym: "sialyltransferase 3C activity" RELATED [EC:2.4.99.7]
synonym: "sialyltransferase 7D activity" RELATED [EC:2.4.99.7]
synonym: "SIAT7" RELATED [EC:2.4.99.7]
synonym: "ST6GALNAC activity" EXACT [EC:2.4.99.7]
xref: EC:2.4.99.7
xref: KEGG:R04635
xref: MetaCyc:2.4.99.7-RXN
xref: Reactome:REACT_115974 "ST6GALNAC3/4 can add a sialic acid to the sialyl T antigen to form the disialyl T antigen, Homo sapiens"
xref: RHEA:10479
is_a: GO:0008373 ! sialyltransferase activity

[Term]
id: GO:0047291
name: lactosylceramide alpha-2,3-sialyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: cytolipin-H + CMP-N-acetylneuraminate = alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + CMP. Alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide is also known as GM3." [EC:2.4.99.9, MetaCyc:2.4.99.9-RXN]
synonym: "CMP-acetylneuraminate-lactosylceramide-sialyltransferase" BROAD [EC:2.4.99.9]
synonym: "CMP-acetylneuraminic acid:lactosylceramide sialyltransferase activity" EXACT [EC:2.4.99.9]
synonym: "CMP-N-acetylneuraminate:lactosylceramide alpha-2,3-N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.9]
synonym: "CMP-sialic acid:lactosylceramide-sialyltransferase activity" EXACT [EC:2.4.99.9]
synonym: "cytidine monophosphoacetylneuraminate-lactosylceramide alpha2,3- sialyltransferase activity" EXACT [EC:2.4.99.9]
synonym: "cytidine monophosphoacetylneuraminate-lactosylceramide sialyltransferase" BROAD [EC:2.4.99.9]
synonym: "ganglioside GM3 synthase activity" EXACT [EC:2.4.99.9]
synonym: "ganglioside GM3 synthetase activity" EXACT [EC:2.4.99.9]
synonym: "GM3 synthase activity" EXACT [EC:2.4.99.9]
synonym: "GM3 synthetase activity" EXACT [EC:2.4.99.9]
synonym: "SAT 1" RELATED [EC:2.4.99.9]
xref: EC:2.4.99.9
xref: MetaCyc:2.4.99.9-RXN
xref: RHEA:18420
is_a: GO:0008373 ! sialyltransferase activity

[Term]
id: GO:0047292
name: trihydroxypterocarpan dimethylallyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (6AS,11AS)-3,6A,9-trihydroxypterocarpan + dimethylallyl-pyrophosphate = glyceollin + diphosphate." [EC:2.5.1.36, MetaCyc:2.5.1.36-RXN]
synonym: "dimethylallyl-diphosphate:(6aS,11aS)-3,6a,9-trihydroxypterocarpan dimethylallyltransferase activity" EXACT [EC:2.5.1.36]
synonym: "dimethylallyl-diphosphate:(6aS,11aS)-3,6a,9-trihydroxypterocarpan dimethyltransferase activity" EXACT [EC:2.5.1.36]
synonym: "dimethylallylpyrophosphate:3,6a,9-trihydroxypterocarpan dimethylallyltransferase activity" EXACT [EC:2.5.1.36]
synonym: "dimethylallylpyrophosphate:trihydroxypterocarpan dimethylallyl transferase activity" EXACT [EC:2.5.1.36]
xref: EC:2.5.1.36
xref: MetaCyc:2.5.1.36-RXN
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0047293
name: 4-hydroxybenzoate nonaprenyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: p-hydroxybenzoate + solanesyl pyrophosphate = nonaprenyl-4-hydroxybenzoate + diphosphate." [EC:2.5.1.39, MetaCyc:2.5.1.39-RXN]
synonym: "4-hydroxybenzoate transferase activity" EXACT [EC:2.5.1.39]
synonym: "nonaprenyl-4-hydroxybenzoate transferase activity" EXACT [EC:2.5.1.39]
synonym: "p-hydroxybenzoate dimethylallyltransferase activity" EXACT [EC:2.5.1.39]
synonym: "p-hydroxybenzoate polyprenyltransferase activity" EXACT [EC:2.5.1.39]
synonym: "p-hydroxybenzoic acid-polyprenyl transferase activity" EXACT [EC:2.5.1.39]
synonym: "p-hydroxybenzoic-polyprenyl transferase activity" EXACT [EC:2.5.1.39]
synonym: "solanesyl-diphosphate:4-hydroxybenzoate nonaprenyltransferase activity" EXACT [EC:2.5.1.39]
xref: EC:2.5.1.39
xref: MetaCyc:2.5.1.39-RXN
is_a: GO:0002094 ! polyprenyltransferase activity

[Term]
id: GO:0047294
name: phosphoglycerol geranylgeranyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: sn-glycerol 1-phosphate + all-trans-geranylgeranyl diphosphate = sn-3-O-(geranylgeranyl)glycerol 1-phosphate + diphosphate." [EC:2.5.1.41, RHEA:23407]
synonym: "geranylgeranyl diphosphate:sn-glyceryl phosphate geranylgeranyltransferase activity" EXACT [EC:2.5.1.41]
synonym: "geranylgeranyl-transferase activity" EXACT [EC:2.5.1.41]
synonym: "glycerol phosphate geranylgeranyltransferase activity" EXACT [EC:2.5.1.41]
xref: EC:2.5.1.41
xref: KEGG:R04158
xref: MetaCyc:2.5.1.41-RXN
xref: RHEA:23407
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0047295
name: geranylgeranylglycerol-phosphate geranylgeranyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: sn-3-O-(geranylgeranyl)glycerol 1-phosphate + all-trans-geranylgeranyl diphosphate = 2,3-di-O-(geranylgeranyl)glycerol 1-phosphate + diphosphate." [EC:2.5.1.42, RHEA:18112]
synonym: "geranylgeranyl diphosphate:sn-3-O-(geranylgeranyl)glycerol 1-phosphate geranylgeranyltransferase activity" EXACT [EC:2.5.1.42]
synonym: "geranylgeranyloxyglycerol phosphate geranylgeranyltransferase activity" EXACT [EC:2.5.1.42]
synonym: "geranylgeranyltransferase II" RELATED [EC:2.5.1.42]
xref: EC:2.5.1.42
xref: KEGG:R04520
xref: MetaCyc:2.5.1.42-RXN
xref: RHEA:18112
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0047296
name: homospermidine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 putrescine = NH3 + sym-homospermidine." [EC:2.5.1.44, MetaCyc:2.5.1.44-RXN]
subset: gosubset_prok
synonym: "putrescine:putrescine 4-aminobutyltransferase (ammonia-forming)" EXACT [EC:2.5.1.44]
xref: EC:2.5.1.44
xref: MetaCyc:2.5.1.44-RXN
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0047297
name: asparagine-oxo-acid transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 2-oxo acid + L-asparagine = an amino acid + 2-oxosuccinamate." [EC:2.6.1.14, MetaCyc:2.6.1.14-RXN]
synonym: "asparagine--oxo-acid aminotransferase activity" EXACT [EC:2.6.1.14]
synonym: "asparagine-keto acid aminotransferase activity" EXACT [EC:2.6.1.14]
synonym: "asparagine-oxo-acid aminotransferase activity" EXACT []
synonym: "L-asparagine:2-oxo-acid aminotransferase activity" EXACT [EC:2.6.1.14]
xref: EC:2.6.1.14
xref: MetaCyc:2.6.1.14-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047298
name: (S)-3-amino-2-methylpropionate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate." [EC:2.6.1.22, RHEA:13996]
subset: gosubset_prok
synonym: "(S)-3-amino-2-methylpropanoate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.22]
synonym: "(S)-3-amino-2-methylpropionate aminotransferase activity" EXACT []
synonym: "beta-aminobutyric transaminase activity" EXACT [EC:2.6.1.22]
synonym: "beta-aminoisobutyrate-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.22]
synonym: "L-3-aminoisobutyrate aminotransferase activity" EXACT [EC:2.6.1.22]
synonym: "L-3-aminoisobutyrate transaminase activity" EXACT [EC:2.6.1.22]
synonym: "L-3-aminoisobutyric aminotransferase activity" EXACT [EC:2.6.1.22]
synonym: "L-AIBAT activity" EXACT [EC:2.6.1.22]
xref: EC:2.6.1.22
xref: KEGG:R04188
xref: MetaCyc:2.6.1.22-RXN
xref: RHEA:13996
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047299
name: tryptophan-phenylpyruvate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: keto-phenylpyruvate + L-tryptophan = 3-(indol-3-yl)pyruvate + L-phenylalanine." [EC:2.6.1.28, RHEA:13744]
synonym: "L-tryptophan-alpha-ketoisocaproate aminotransferase activity" EXACT [EC:2.6.1.28]
synonym: "L-tryptophan:phenylpyruvate aminotransferase activity" EXACT [EC:2.6.1.28]
synonym: "tryptophan--phenylpyruvate aminotransferase activity" EXACT [EC:2.6.1.28]
synonym: "tryptophan-phenylpyruvate aminotransferase activity" EXACT []
xref: EC:2.6.1.28
xref: KEGG:R01376
xref: MetaCyc:2.6.1.28-RXN
xref: RHEA:13744
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047300
name: pyridoxamine-pyruvate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyridoxamine + pyruvate = L-alanine + pyridoxal." [EC:2.6.1.30, RHEA:12844]
synonym: "pyridoxamine--pyruvate aminotransferase activity" EXACT [EC:2.6.1.30]
synonym: "pyridoxamine-pyruvate aminotransferase activity" EXACT []
synonym: "pyridoxamine-pyruvic transaminase" BROAD [EC:2.6.1.30]
synonym: "pyridoxamine:pyruvate aminotransferase activity" EXACT [EC:2.6.1.30]
synonym: "pyridoxamineu-pyruvic transaminase activity" EXACT [EC:2.6.1.30]
xref: EC:2.6.1.30
xref: KEGG:R01712
xref: MetaCyc:2.6.1.30-RXN
xref: RHEA:12844
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047301
name: valine-3-methyl-2-oxovalerate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-3-methyl-2-oxopentanoate + L-valine = 3-methyl-2-oxobutanoate + L-isoleucine." [EC:2.6.1.32, RHEA:11471]
synonym: "L-valine:(S)-3-methyl-2-oxopentanoate aminotransferase activity" EXACT [EC:2.6.1.32]
synonym: "valine--3-methyl-2-oxovalerate aminotransferase activity" EXACT [EC:2.6.1.32]
synonym: "valine--isoleucine aminotransferase activity" EXACT [EC:2.6.1.32]
synonym: "valine--isoleucine transaminase activity" EXACT [EC:2.6.1.32]
synonym: "valine-2-keto-methylvalerate aminotransferase activity" EXACT [EC:2.6.1.32]
synonym: "valine-3-methyl-2-oxovalerate aminotransferase activity" EXACT []
xref: EC:2.6.1.32
xref: KEGG:R02200
xref: MetaCyc:2.6.1.32-RXN
xref: RHEA:11471
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047302
name: UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + UDP-2-acetamido-4-amino-2,4,6-trideoxy-D-glucose = L-glutamate + UDP-2-acetamido-4-dehydro-2,6-dideoxy-beta-D-glucose." [EC:2.6.1.34, RHEA:18716]
synonym: "UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.34]
synonym: "UDP-4-amino-2-acetamido-2,4,6-trideoxyglucose aminotransferase activity" EXACT []
synonym: "UDP-4-amino-2-acetamido-2,4,6-trideoxyglucose transaminase activity" EXACT []
synonym: "uridine diphospho-4-amino-2-acetamido-2,4,6-trideoxyglucose aminotransferase activity" EXACT [EC:2.6.1.34]
xref: EC:2.6.1.34
xref: KEGG:R04529
xref: MetaCyc:2.6.1.34-RXN
xref: RHEA:18716
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047303
name: glycine-oxaloacetate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycine + oxaloacetate = L-aspartate + glyoxylate." [EC:2.6.1.35, RHEA:17144]
synonym: "glycine--oxaloacetate aminotransferase activity" EXACT [EC:2.6.1.35]
synonym: "glycine-oxalacetate aminotransferase activity" EXACT [EC:2.6.1.35]
synonym: "glycine-oxaloacetate aminotransferase activity" EXACT []
synonym: "glycine:oxaloacetate aminotransferase activity" EXACT [EC:2.6.1.35]
xref: EC:2.6.1.35
xref: KEGG:R00373
xref: MetaCyc:2.6.1.35-RXN
xref: RHEA:17144
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047304
name: 2-aminoethylphosphonate-pyruvate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2-aminoethyl)phosphonate + pyruvate = L-alanine + phosphonoacetaldehyde." [EC:2.6.1.37, RHEA:17024]
subset: gosubset_prok
synonym: "(2-aminoethyl)phosphonate aminotransferase activity" EXACT [EC:2.6.1.37]
synonym: "(2-aminoethyl)phosphonate transaminase activity" EXACT [EC:2.6.1.37]
synonym: "(2-aminoethyl)phosphonate--pyruvate aminotransferase activity" EXACT [EC:2.6.1.37]
synonym: "(2-aminoethyl)phosphonate:pyruvate aminotransferase activity" EXACT [EC:2.6.1.37]
synonym: "(2-aminoethyl)phosphonic acid aminotransferase activity" EXACT [EC:2.6.1.37]
synonym: "2-aminoethylphosphonate aminotransferase activity" EXACT [EC:2.6.1.37]
synonym: "2-aminoethylphosphonate--pyruvate aminotransferase activity" EXACT [EC:2.6.1.37]
synonym: "2-aminoethylphosphonate-pyruvate aminotransferase activity" EXACT []
xref: EC:2.6.1.37
xref: KEGG:R04152
xref: MetaCyc:2.6.1.37-RXN
xref: RHEA:17024
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047305
name: (R)-3-amino-2-methylpropionate-pyruvate transaminase activity
namespace: molecular_function
alt_id: GO:0047314
def: "Catalysis of the reaction: (2R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine." [EC:2.6.1.40, RHEA:18396]
comment: Note that this function was EC:2.6.1.61.
synonym: "(R)-3-amino-2-methylpropanoate aminotransferase activity" EXACT []
synonym: "(R)-3-amino-2-methylpropanoate transaminase activity" EXACT []
synonym: "(R)-3-amino-2-methylpropanoate:pyruvate aminotransferase activity" EXACT [EC:2.6.1.40]
synonym: "(R)-3-amino-2-methylpropionate transaminase activity" EXACT []
synonym: "(R)-3-amino-2-methylpropionate--pyruvate aminotransferase activity" EXACT [EC:2.6.1.40]
synonym: "(R)-3-amino-2-methylpropionate-pyruvate aminotransferase activity" EXACT []
synonym: "beta-aminoisobutyrate--pyruvate transaminase activity" EXACT [EC:2.6.1.40]
synonym: "beta-aminoisobutyrate-pyruvate aminotransferase activity" EXACT [EC:2.6.1.40]
synonym: "D-3-aminoisobutyrate--pyruvate aminotransferase activity" EXACT [EC:2.6.1.40]
synonym: "D-3-aminoisobutyrate--pyruvate transaminase activity" EXACT [EC:2.6.1.40]
synonym: "D-3-aminoisobutyrate-pyruvate transaminase activity" EXACT [EC:2.6.1.40]
synonym: "D-AIBAT activity" EXACT [EC:2.6.1.40]
synonym: "D-beta-aminoisobutyrate:pyruvate aminotransferase activity" EXACT [EC:2.6.1.40]
xref: EC:2.6.1.40
xref: KEGG:R02050
xref: MetaCyc:2.6.1.40-RXN
xref: Reactome:REACT_25332 "(R)-3-aminoisobutyric acid + pyruvate => 2-methyl-3-oxopropanoate + alanine, Homo sapiens"
xref: Reactome:REACT_25337 "(R)-3-aminoisobutyric acid + pyruvate => 2-methyl-3-oxopropanoate + alanine, Rattus norvegicus"
xref: RHEA:18396
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047306
name: D-methionine-pyruvate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-methionine + pyruvate = 4-methylthio-2-oxobutanoate + L-alanine." [EC:2.6.1.41, RHEA:23839]
synonym: "D-methionine aminotransferase activity" EXACT [EC:2.6.1.41]
synonym: "D-methionine transaminase activity" EXACT [EC:2.6.1.41]
synonym: "D-methionine--pyruvate aminotransferase activity" EXACT [EC:2.6.1.41]
synonym: "D-methionine-pyruvate aminotransferase activity" EXACT []
synonym: "D-methionine:pyruvate aminotransferase activity" EXACT [EC:2.6.1.41]
xref: EC:2.6.1.41
xref: KEGG:R03001
xref: MetaCyc:2.6.1.41-RXN
xref: RHEA:23839
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047307
name: diaminobutyrate-pyruvate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-2,4-diaminobutyrate + pyruvate = L-alanine + L-aspartate 4-semialdehyde." [EC:2.6.1.46, RHEA:12383]
subset: gosubset_prok
synonym: "diaminobutyrate--pyruvate aminotransferase activity" EXACT [EC:2.6.1.46]
synonym: "diaminobutyrate-pyruvate aminotransferase activity" EXACT []
synonym: "L-2,4-diaminobutanoate:pyruvate aminotransferase activity" EXACT [EC:2.6.1.46]
synonym: "L-diaminobutyric acid transaminase activity" EXACT [EC:2.6.1.46]
xref: EC:2.6.1.46
xref: KEGG:R02293
xref: MetaCyc:2.6.1.46-RXN
xref: RHEA:12383
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047308
name: alanine-oxomalonate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-alanine + oxomalonate = aminomalonate + pyruvate." [EC:2.6.1.47, RHEA:18812]
synonym: "alanine--oxomalonate aminotransferase activity" EXACT [EC:2.6.1.47]
synonym: "alanine-ketomalonate (mesoxalate) transaminase activity" EXACT [EC:2.6.1.47]
synonym: "alanine-oxomalonate aminotransferase activity" EXACT []
synonym: "L-alanine-ketomalonate transaminase activity" EXACT [EC:2.6.1.47]
synonym: "L-alanine:oxomalonate aminotransferase activity" EXACT [EC:2.6.1.47]
xref: EC:2.6.1.47
xref: KEGG:R02970
xref: MetaCyc:2.6.1.47-RXN
xref: RHEA:18812
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047309
name: dihydroxyphenylalanine transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + L-dopa = 3,4-dihydroxyphenylpyruvate + L-glutamate." [EC:2.6.1.49, RHEA:15276]
synonym: "3,4-dihydroxy-L-phenylalanine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.49]
synonym: "aspartate-DOPP transaminase (ADT)" EXACT [EC:2.6.1.49]
synonym: "dihydroxyphenylalanine aminotransferase activity" EXACT []
synonym: "DOPA aminotransferase activity" EXACT [EC:2.6.1.49]
synonym: "dopa transaminase activity" EXACT [EC:2.6.1.49]
synonym: "glutamate-DOPP transaminase (GDT)" EXACT [EC:2.6.1.49]
synonym: "L-dopa transaminase activity" EXACT [EC:2.6.1.49]
synonym: "phenylalanine-DOPP transaminase (PDT)" EXACT [EC:2.6.1.49]
xref: EC:2.6.1.49
xref: KEGG:R02077
xref: MetaCyc:2.6.1.49-RXN
xref: RHEA:15276
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047310
name: glutamine-scyllo-inositol transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4,6/3,5-pentahydroxycyclohexanone + L-glutamine = 1-amino-1-deoxy-scyllo-inositol + 2-oxoglutaramate." [EC:2.6.1.50, RHEA:22923]
subset: gosubset_prok
synonym: "glutamine scyllo-inosose aminotransferase activity" EXACT [EC:2.6.1.50]
synonym: "glutamine--scyllo-inosose aminotransferase activity" EXACT [EC:2.6.1.50]
synonym: "glutamine--scyllo-inosose transaminase activity" EXACT [EC:2.6.1.50]
synonym: "glutamine-scyllo-inosose aminotransferase activity" EXACT []
synonym: "glutamine-scyllo-inosose transaminase activity" EXACT []
synonym: "L-glutamine-keto-scyllo-inositol aminotransferase activity" EXACT [EC:2.6.1.50]
synonym: "L-glutamine-scyllo-inosose transaminase activity" EXACT [EC:2.6.1.50]
synonym: "L-glutamine:2,4,6/3,5-pentahydroxycyclohexanone aminotransferase activity" EXACT [EC:2.6.1.50]
xref: EC:2.6.1.50
xref: KEGG:R02781
xref: MetaCyc:2.6.1.50-RXN
xref: RHEA:22923
is_a: GO:0070548 ! L-glutamine aminotransferase activity

[Term]
id: GO:0047311
name: 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol + pyruvate = 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol + L-alanine." [EC:2.6.1.56, RHEA:15500]
synonym: "1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol aminotransferase activity" EXACT []
synonym: "1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol:pyruvate aminotransferase activity" EXACT [EC:2.6.1.56]
synonym: "guanidinoaminodideoxy-scyllo-inositol-pyruvate aminotransferase activity" EXACT [EC:2.6.1.56]
synonym: "L-alanine-N-amidino-3-(or 5-)keto-scyllo-inosamine transaminase activity" EXACT [EC:2.6.1.56]
xref: EC:2.6.1.56
xref: KEGG:R03502
xref: MetaCyc:2.6.1.56-RXN
xref: RHEA:15500
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047312
name: L-phenylalanine:pyruvate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyruvate + L-phenylalanine = phenylpyruvate + L-alanine." [EC:2.6.1.58, MetaCyc:2.6.1.58-RXN]
synonym: "histidine aminotransferase activity" RELATED [GOC:kad]
synonym: "histidine:pyruvate aminotransferase activity" RELATED [EC:2.6.1.58, GOC:kad]
synonym: "L-histidine:pyruvate aminotransferase activity" RELATED [GOC:kad]
synonym: "L-phenylalanine(L-histidine):pyruvate aminotransferase activity" BROAD [EC:2.6.1.58]
synonym: "L-phenylalanine:pyruvate transaminase activity" EXACT [GOC:kad]
synonym: "phenylalanine (histidine) aminotransferase activity" BROAD [EC:2.6.1.58]
synonym: "phenylalanine(histidine) aminotransferase activity" BROAD []
synonym: "phenylalanine(histidine) transaminase activity" BROAD [EC:2.6.1.58]
synonym: "phenylalanine(histidine):pyruvate aminotransferase activity" BROAD [EC:2.6.1.58]
xref: EC:2.6.1.58
xref: KEGG:R00692
xref: MetaCyc:2.6.1.58-RXN
xref: Reactome:REACT_25224 "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine, Homo sapiens"
is_a: GO:0070546 ! L-phenylalanine aminotransferase activity

[Term]
id: GO:0047313
name: aromatic-amino-acid-glyoxylate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: glyoxylate + an aromatic amino acid = L-glycine + an aromatic oxo acid." [EC:2.6.1.60, MetaCyc:2.6.1.60-RXN]
synonym: "aromatic-amino-acid--glyoxylate aminotransferase activity" EXACT [EC:2.6.1.60]
synonym: "aromatic-amino-acid-glyoxylate aminotransferase activity" EXACT []
synonym: "aromatic-amino-acid:glyoxylate aminotransferase activity" EXACT [EC:2.6.1.60]
xref: EC:2.6.1.60
xref: MetaCyc:2.6.1.60-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047315
name: kynurenine-glyoxylate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-kynurenine + glyoxylate = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine." [EC:2.6.1.63, RHEA:19252]
synonym: "kynurenine--glyoxylate aminotransferase activity" EXACT [EC:2.6.1.63]
synonym: "kynurenine-glyoxylate aminotransferase activity" EXACT []
synonym: "L-kynurenine:glyoxylate aminotransferase (cyclizing)" EXACT [EC:2.6.1.63]
xref: EC:2.6.1.63
xref: KEGG:R01957
xref: MetaCyc:2.6.1.63-RXN
xref: RHEA:19252
is_a: GO:0036137 ! kynurenine aminotransferase activity

[Term]
id: GO:0047316
name: glutamine-phenylpyruvate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: keto-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine." [EC:2.6.1.64, RHEA:17596]
synonym: "glutamine transaminase K activity" RELATED [EC:2.6.1.64]
synonym: "glutamine--phenylpyruvate aminotransferase activity" EXACT [EC:2.6.1.64]
synonym: "glutamine-phenylpyruvate aminotransferase activity" EXACT []
synonym: "L-glutamine:phenylpyruvate aminotransferase activity" EXACT [EC:2.6.1.64]
xref: EC:2.6.1.64
xref: KEGG:R01375
xref: MetaCyc:2.6.1.64-RXN
xref: RHEA:17596
is_a: GO:0070548 ! L-glutamine aminotransferase activity

[Term]
id: GO:0047317
name: N6-acetyl-beta-lysine transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + 3-amino-6-acetamidohexanoate = L-glutamate + 3-oxo-6-acetamidohexanoate." [EC:2.6.1.65, MetaCyc:2.6.1.65-RXN]
synonym: "6-acetamido-3-aminohexanoate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.65]
synonym: "epsilon-acetyl-beta-lysine aminotransferase activity" EXACT [EC:2.6.1.65]
synonym: "N(6)-acetyl-beta-lysine aminotransferase activity" EXACT [EC:2.6.1.65]
synonym: "N6-acetyl-beta-lysine aminotransferase activity" EXACT []
xref: EC:2.6.1.65
xref: MetaCyc:2.6.1.65-RXN
xref: RHEA:16892
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047319
name: aspartate-phenylpyruvate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: keto-phenylpyruvate + L-aspartate = L-phenylalanine + oxaloacetate." [EC:2.6.1.70, RHEA:14100]
synonym: "aspartate--phenylpyruvate aminotransferase activity" EXACT [EC:2.6.1.70]
synonym: "aspartate-phenylpyruvate aminotransferase activity" EXACT []
synonym: "L-aspartate:phenylpyruvate aminotransferase activity" EXACT [EC:2.6.1.70]
xref: EC:2.6.1.70
xref: KEGG:R00695
xref: MetaCyc:2.6.1.70-RXN
xref: RHEA:14100
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047320
name: D-4-hydroxyphenylglycine transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + D-4-hydroxyphenylglycine = 4-hydroxyphenylglyoxylate + L-glutamate." [EC:2.6.1.72, RHEA:15592]
synonym: "D-4-hydroxyphenylglycine aminotransferase activity" EXACT []
synonym: "D-4-hydroxyphenylglycine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.72]
synonym: "D-hydroxyphenylglycine aminotransferase activity" EXACT [EC:2.6.1.72]
xref: EC:2.6.1.72
xref: KEGG:R04234
xref: MetaCyc:2.6.1.72-RXN
xref: RHEA:15592
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047321
name: diphosphate-protein phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: microsomal-membrane protein + diphosphate = diphosphate + O-phospho-microsomal-membrane protein." [EC:2.7.99.1, MetaCyc:2.7.99.1-RXN]
synonym: "diphosphate:microsomal-membrane-protein O-phosphotransferase activity" BROAD [EC:2.7.99.1]
synonym: "DiPPT" RELATED [EC:2.7.99.1]
synonym: "pyrophosphate-protein phosphotransferase activity" EXACT [EC:2.7.99.1]
synonym: "pyrophosphate:protein phosphotransferase activity" EXACT [EC:2.7.99.1]
synonym: "triphosphate-protein phosphotransferase activity" EXACT [EC:2.7.99.1]
synonym: "triphosphate:microsomal-membrane-protein phosphotransferase activity" EXACT [EC:2.7.99.1]
xref: EC:2.7.99.1
xref: MetaCyc:2.7.99.1-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047322
name: [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: [3-hydroxy-3-methylglutaryl-CoA reductase (NADPH)] + ATP = [3-hydroxy-3-methylglutaryl-CoA reductase (NADPH)] phosphate + ADP." [EC:2.7.11.31, MetaCyc:2.7.1.109-RXN]
synonym: "3-hydroxy-3-methylglutaryl coenzyme A reductase kinase activity" EXACT [EC:2.7.11.31]
synonym: "3-hydroxy-3-methylglutaryl-CoA reductase kinase activity" EXACT [EC:2.7.11.31]
synonym: "AMPK" RELATED [EC:2.7.11.31]
synonym: "ATP:hydroxymethylglutaryl-CoA reductase (NADPH) phosphotransferase activity" EXACT [EC:2.7.11.31]
synonym: "beta-hydroxy-beta-methylglutaryl-CoA reductase kinase activity" EXACT [EC:2.7.11.31]
synonym: "HMG-CoA reductase kinase activity" EXACT [EC:2.7.11.31]
synonym: "hydroxymethylglutaryl coenzyme A reductase kinase (phosphorylating) activity" EXACT [EC:2.7.11.31]
synonym: "hydroxymethylglutaryl coenzyme A reductase kinase activity" EXACT [EC:2.7.11.31]
synonym: "hydroxymethylglutaryl-CoA reductase (NADPH) kinase activity" EXACT [EC:2.7.11.31]
synonym: "hydroxymethylglutaryl-CoA reductase (NADPH2) kinase activity" EXACT [EC:2.7.11.31]
synonym: "hydroxymethylglutaryl-CoA reductase kinase activity" EXACT [EC:2.7.11.31]
synonym: "reductase kinase activity" BROAD [EC:2.7.11.31]
synonym: "STK29" RELATED [EC:2.7.11.31]
xref: EC:2.7.11.31
xref: MetaCyc:2.7.1.109-RXN
is_a: GO:0004672 ! protein kinase activity

[Term]
id: GO:0047323
name: [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) = ADP + 3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) phosphate." [EC:2.7.11.4]
synonym: "3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase activity" EXACT [EC:2.7.11.4]
synonym: "[3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] kinase activity" EXACT []
synonym: "ATP:3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) phosphotransferase activity" EXACT [EC:2.7.11.4]
synonym: "BCK" RELATED [EC:2.7.11.4]
synonym: "BCKD kinase activity" EXACT [EC:2.7.11.4]
synonym: "BCODH kinase activity" EXACT [EC:2.7.11.4]
synonym: "branched-chain 2-oxo acid dehydrogenase kinase activity" EXACT [EC:2.7.11.4]
synonym: "branched-chain alpha-ketoacid dehydrogenase kinase activity" EXACT [EC:2.7.11.4]
synonym: "branched-chain keto acid dehydrogenase kinase activity" EXACT [EC:2.7.11.4]
synonym: "branched-chain oxo acid dehydrogenase kinase (phosphorylating) activity" EXACT [EC:2.7.11.4]
synonym: "STK2" RELATED [EC:2.7.11.4]
xref: EC:2.7.11.4
xref: MetaCyc:2.7.11.4-RXN
is_a: GO:0004672 ! protein kinase activity

[Term]
id: GO:0047324
name: phosphoenolpyruvate-glycerone phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycerone + phosphoenolpyruvate = glycerone phosphate + pyruvate." [EC:2.7.1.121, RHEA:18384]
synonym: "phosphoenolpyruvate:glycerone phosphotransferase activity" EXACT [EC:2.7.1.121]
xref: EC:2.7.1.121
xref: KEGG:R01012
xref: MetaCyc:2.7.1.121-RXN
xref: RHEA:18384
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047325
name: inositol tetrakisphosphate 1-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP." [EC:2.7.1.134, MetaCyc:2.7.1.134-RXN]
synonym: "1D-myo-inositol-tetrakisphosphate 1-kinase activity" EXACT [EC:2.7.1.134]
synonym: "1D-myo-inositol-trisphosphate 5-kinase activity" RELATED [EC:2.7.1.134]
synonym: "1D-myo-inositol-trisphosphate 6-kinase activity" RELATED [EC:2.7.1.134]
synonym: "ATP:1D-myo-inositol-3,4,5,6-tetrakisphosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.134]
synonym: "inositol 3,4,5,6-tetrakisphosphate 1-kinase activity" EXACT []
synonym: "inositol-tetrakisphosphate 1-kinase activity" BROAD []
synonym: "inositol-trisphosphate 5-kinase activity" RELATED [EC:2.7.1.134]
synonym: "inositol-trisphosphate 6-kinase activity" RELATED [EC:2.7.1.134]
xref: EC:2.7.1.134
xref: MetaCyc:2.7.1.134-RXN
xref: Reactome:REACT_25076 "ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5, Homo sapiens"
xref: RHEA:12455
is_a: GO:0051765 ! inositol tetrakisphosphate kinase activity

[Term]
id: GO:0047326
name: inositol tetrakisphosphate 5-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP." [EC:2.7.1.140, MetaCyc:2.7.1.140-RXN]
synonym: "1D-myo-inositol-tetrakisphosphate 5-kinase activity" EXACT []
synonym: "ATP:1D-myo-inositol-1,3,4,6-tetrakisphosphate 5-phosphotransferase activity" EXACT [EC:2.7.1.140]
synonym: "inositol 1,3,4,6-tetrakisphosphate 5-kinase activity" EXACT []
synonym: "inositol-tetrakisphosphate 5-kinase activity" EXACT []
xref: EC:2.7.1.140
xref: MetaCyc:2.7.1.140-RXN
xref: RHEA:12720
is_a: GO:0051765 ! inositol tetrakisphosphate kinase activity

[Term]
id: GO:0047327
name: glycerol-3-phosphate-glucose phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: sn-glycerol 3-phosphate + D-glucose = D-glucose 6-phosphate + glycerol." [EC:2.7.1.142, RHEA:21291]
synonym: "sn-glycerol-3-phosphate:D-glucose 6-phosphotransferase activity" EXACT [EC:2.7.1.142]
xref: EC:2.7.1.142
xref: KEGG:R00850
xref: MetaCyc:2.7.1.142-RXN
xref: RHEA:21291
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047328
name: acyl-phosphate-hexose phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-hexose + acyl phosphate = D-hexose phosphate + an acid." [EC:2.7.1.61, MetaCyc:2.7.1.61-RXN]
synonym: "acyl-phosphate:D-hexose phosphotransferase activity" EXACT [EC:2.7.1.61]
synonym: "hexose phosphate:hexose phosphotransferase activity" EXACT [EC:2.7.1.61]
xref: EC:2.7.1.61
xref: MetaCyc:2.7.1.61-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047329
name: phosphoramidate-hexose phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: hexose + phosphoramidate = hexose 1-phosphate + NH3." [EC:2.7.1.62, MetaCyc:2.7.1.62-RXN]
synonym: "phosphoramidate-hexose transphosphorylase activity" EXACT [EC:2.7.1.62]
synonym: "phosphoramidate:hexose 1-phosphotransferase activity" EXACT [EC:2.7.1.62]
synonym: "phosphoramidic-hexose transphosphorylase activity" EXACT [EC:2.7.1.62]
xref: EC:2.7.1.62
xref: MetaCyc:2.7.1.62-RXN
xref: RHEA:10975
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047330
name: polyphosphate-glucose phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-D-glucose + long chain polyphosphate = glucose-6-phosphate + long chain polyphosphate." [EC:2.7.1.63, MetaCyc:2.7.1.63-RXN]
subset: gosubset_prok
synonym: "polyphosphate glucokinase activity" EXACT [EC:2.7.1.63]
synonym: "polyphosphate-D-(+)-glucose-6-phosphotransferase activity" EXACT [EC:2.7.1.63]
synonym: "polyphosphate-glucose 6-phosphotransferase activity" EXACT [EC:2.7.1.63]
synonym: "polyphosphate:D-glucose 6-phosphotransferase activity" EXACT [EC:2.7.1.63]
xref: EC:2.7.1.63
xref: MetaCyc:2.7.1.63-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047331
name: diphosphate-glycerol phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycerol + diphosphate = glycerol 1-phosphate + H(+) + phosphate." [EC:2.7.1.79, RHEA:13692]
synonym: "diphosphate:glycerol 1-phosphotransferase activity" EXACT [EC:2.7.1.79]
synonym: "PPi-glycerol phosphotransferase activity" EXACT [EC:2.7.1.79]
synonym: "pyrophosphate--glycerol phosphotransferase activity" EXACT [EC:2.7.1.79]
xref: EC:2.7.1.79
xref: KEGG:R01044
xref: MetaCyc:2.7.1.79-RXN
xref: RHEA:13692
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047332
name: diphosphate-serine phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-serine + diphosphate = O-phospho-L-serine + H(+) + phosphate." [EC:2.7.1.80, RHEA:23767]
synonym: "diphosphate:L-serine O-phosphotransferase activity" EXACT [EC:2.7.1.80]
synonym: "pyrophosphate--serine phosphotransferase activity" EXACT [EC:2.7.1.80]
synonym: "pyrophosphate-L-serine phosphotransferase activity" EXACT [EC:2.7.1.80]
xref: EC:2.7.1.80
xref: KEGG:R00584
xref: MetaCyc:2.7.1.80-RXN
xref: RHEA:23767
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047333
name: dihydrostreptomycin-6-phosphate 3'-alpha-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + dihydrostreptomycin 6-phosphate = ADP + dihydrostreptomycin 3'alpha,6-bisphosphate + 2 H(+)." [EC:2.7.1.88, RHEA:16284]
synonym: "ATP:dihydrostreptomycin-6-P 3'alpha-phosphotransferase activity" EXACT [EC:2.7.1.88]
synonym: "ATP:dihydrostreptomycin-6-phosphate 3'alpha-phosphotransferase activity" EXACT [EC:2.7.1.88]
synonym: "dihydrostreptomycin 6-phosphate kinase (phosphorylating)" EXACT [EC:2.7.1.88]
synonym: "dihydrostreptomycin-6-phosphate 3'alpha-kinase activity" EXACT [EC:2.7.1.88]
xref: EC:2.7.1.88
xref: KEGG:R03395
xref: MetaCyc:2.7.1.88-RXN
xref: RHEA:16284
is_a: GO:0034071 ! aminoglycoside phosphotransferase activity

[Term]
id: GO:0047334
name: diphosphate-fructose-6-phosphate 1-phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: fructose-6-phosphate + diphosphate = phosphate + fructose-1,6-bisphosphate." [EC:2.7.1.90, MetaCyc:2.7.1.90-RXN]
subset: gosubset_prok
synonym: "6-phosphofructokinase (diphosphate) activity" EXACT [EC:2.7.1.90]
synonym: "6-phosphofructokinase (pyrophosphate) activity" EXACT [EC:2.7.1.90]
synonym: "diphosphate-dependent 6-phosphofructose-1-kinase activity" EXACT [EC:2.7.1.90]
synonym: "diphosphate:D-fructose-6-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.90]
synonym: "inorganic pyrophosphate-dependent phosphofructokinase activity" EXACT [EC:2.7.1.90]
synonym: "inorganic pyrophosphate-phosphofructokinase activity" EXACT [EC:2.7.1.90]
synonym: "pyrophosphate--fructose 6-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.90]
synonym: "pyrophosphate-dependent 6-phosphofructose-1-kinase activity" EXACT [EC:2.7.1.90]
synonym: "pyrophosphate-dependent phosphofructo-1-kinase activity" EXACT [EC:2.7.1.90]
synonym: "pyrophosphate-fructose 6-phosphate phosphotransferase activity" EXACT [EC:2.7.1.90]
xref: EC:2.7.1.90
xref: MetaCyc:2.7.1.90-RXN
xref: RHEA:13616
is_a: GO:0008443 ! phosphofructokinase activity

[Term]
id: GO:0047335
name: 3-phosphoglyceroyl-phosphate-polyphosphate phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: long-chain-polyphosphate + 3-phospho-D-glyceroyl-phosphate = long-chain-polyphosphate + 3-phosphoglycerate." [EC:2.7.4.17, MetaCyc:2.7.4.17-RXN]
synonym: "1,3-diphosphoglycerate-polyphosphate phosphotransferase activity" EXACT [EC:2.7.4.17]
synonym: "3-phospho-D-glyceroyl-phosphate:polyphosphate phosphotransferase activity" EXACT [EC:2.7.4.17]
synonym: "diphosphoglycerate-polyphosphate phosphotransferase activity" EXACT [EC:2.7.4.17]
xref: EC:2.7.4.17
xref: MetaCyc:2.7.4.17-RXN
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor

[Term]
id: GO:0047336
name: 5-methyldeoxycytidine-5'-phosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2'-deoxy-5-methyl-5'-cytidylate + ATP = 5-methyldeoxycytidine diphosphate + ADP + H(+)." [EC:2.7.4.19, RHEA:11399]
synonym: "ATP:5-methyldeoxycytidine-5'-phosphate phosphotransferase activity" EXACT [EC:2.7.4.19]
xref: EC:2.7.4.19
xref: KEGG:R04235
xref: MetaCyc:2.7.4.19-RXN
xref: RHEA:11399
is_a: GO:0016301 ! kinase activity
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor

[Term]
id: GO:0047337
name: dolichyl-diphosphate-polyphosphate phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: dolichyl diphosphate + long-chain-polyphosphate = dolichol-phosphate + long-chain-polyphosphate." [EC:2.7.4.20, MetaCyc:2.7.4.20-RXN]
synonym: "dolichyl-diphosphate:polyphosphate phosphotransferase activity" EXACT [EC:2.7.4.20]
synonym: "dolichylpyrophosphate:polyphosphate phosphotransferase activity" EXACT [EC:2.7.4.20]
xref: EC:2.7.4.20
xref: MetaCyc:2.7.4.20-RXN
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor

[Term]
id: GO:0047338
name: UTP:xylose-1-phosphate uridylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-xylose 1-phosphate + UTP = UDP-D-xylose + diphosphate." [EC:2.7.7.11, MetaCyc:2.7.7.11-RXN]
synonym: "UDP-xylose pyrophosphorylase activity" EXACT [EC:2.7.7.11]
synonym: "uridine diphosphoxylose pyrophosphorylase activity" EXACT [EC:2.7.7.11]
synonym: "uridylyltransferase, xylose 1-phosphate" EXACT [EC:2.7.7.11]
synonym: "UTP-xylose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.11]
synonym: "UTP:alpha-D-xylose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.11]
synonym: "xylose 1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.11]
synonym: "xylose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.11]
xref: EC:2.7.7.11
xref: MetaCyc:2.7.7.11-RXN
xref: RHEA:18392
is_a: GO:0051748 ! UTP-monosaccharide-1-phosphate uridylyltransferase activity

[Term]
id: GO:0047339
name: nucleoside-triphosphate-hexose-1-phosphate nucleotidyltransferase activity
namespace: molecular_function
alt_id: GO:0047340
def: "Catalysis of the reaction: hexose 1-phosphate + nucleoside triphosphate = NDP-hexose + diphosphate." [EC:2.7.7.28, MetaCyc:2.7.7.28-RXN]
synonym: "GDP hexose pyrophosphorylase activity" NARROW [EC:2.7.7.28]
synonym: "GTP:alpha-D-hexose-1-phosphate guanylyltransferase activity" NARROW [EC:2.7.7.28]
synonym: "GTP:hexose-1-phosphate guanylyltransferase activity" NARROW []
synonym: "guanosine diphosphohexose pyrophosphorylase activity" NARROW [EC:2.7.7.28]
synonym: "hexose 1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.28]
synonym: "hexose 1-phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.28]
synonym: "hexose nucleotidylating enzyme activity" EXACT [EC:2.7.7.28]
synonym: "hexose-1-phosphate guanylyltransferase activity" NARROW []
synonym: "NDP hexose pyrophosphorylase activity" EXACT [EC:2.7.7.28]
synonym: "NDP-hexose diphosphorylase activity" EXACT []
synonym: "NDP-hexose pyrophosphorylase activity" EXACT []
synonym: "NTP:alpha-D-aldose-1-phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.28]
synonym: "NTP:hexose-1-phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.28]
synonym: "nucleoside diphosphohexose pyrophosphorylase activity" EXACT [EC:2.7.7.28]
synonym: "nucleoside-triphosphate-aldose-1-phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.28]
xref: EC:2.7.7.28
xref: MetaCyc:2.7.7.28-RXN
is_a: GO:0016779 ! nucleotidyltransferase activity

[Term]
id: GO:0047341
name: fucose-1-phosphate guanylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-L-fucose 1-phosphate + GTP = diphosphate + GDP-L-fucose." [EC:2.7.7.30, RHEA:13552]
synonym: "GDP fucose pyrophosphorylase activity" EXACT [EC:2.7.7.30]
synonym: "GDP-fucose diphosphorylase activity" EXACT [EC:2.7.7.30]
synonym: "GDP-fucose pyrophosphorylase activity" EXACT [EC:2.7.7.30]
synonym: "GDP-L-fucose pyrophosphorylase activity" EXACT [EC:2.7.7.30]
synonym: "GTP:beta-L-fucose-1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.30]
synonym: "GTP:fucose-1-phosphate guanylyltransferase activity" EXACT []
synonym: "GTP:L-fucose-1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.30]
synonym: "guanosine diphosphate L-fucose pyrophosphorylase activity" EXACT [EC:2.7.7.30]
xref: EC:2.7.7.30
xref: KEGG:R01951
xref: MetaCyc:2.7.7.30-RXN
xref: RHEA:13552
is_a: GO:0070568 ! guanylyltransferase activity

[Term]
id: GO:0047342
name: galactose-1-phosphate thymidylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-galactose 1-phosphate + dTTP = diphosphate + dTDP-D-galactose." [EC:2.7.7.32, RHEA:17168]
synonym: "dTDP galactose pyrophosphorylase activity" EXACT [EC:2.7.7.32]
synonym: "dTDP-galactose diphosphorylase activity" EXACT [EC:2.7.7.32]
synonym: "dTDP-galactose pyrophosphorylase activity" EXACT [EC:2.7.7.32]
synonym: "dTTP:alpha-D-galactose-1-phosphate thymidylyltransferase activity" EXACT [EC:2.7.7.32]
synonym: "galactose 1-phosphate thymidylyl transferase activity" EXACT [EC:2.7.7.32]
synonym: "thymidine diphosphogalactose pyrophosphorylase activity" EXACT [EC:2.7.7.32]
synonym: "thymidine triphosphate:alpha-D-galactose 1-phosphate thymidylyltransferase activity" EXACT [EC:2.7.7.32]
xref: EC:2.7.7.32
xref: KEGG:R02329
xref: MetaCyc:2.7.7.32-RXN
xref: RHEA:17168
is_a: GO:0016779 ! nucleotidyltransferase activity

[Term]
id: GO:0047343
name: glucose-1-phosphate cytidylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate + CTP = CDP-D-glucose + diphosphate." [EC:2.7.7.33, RHEA:18216]
subset: gosubset_prok
synonym: "CDP glucose pyrophosphorylase activity" EXACT [EC:2.7.7.33]
synonym: "CDP-glucose diphosphorylase activity" EXACT [EC:2.7.7.33]
synonym: "CDP-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.33]
synonym: "CTP:alpha-D-glucose-1-phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.33]
synonym: "CTP:D-glucose-1-phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.33]
synonym: "CTP:glucose-1-phosphate cytidylyltransferase activity" EXACT []
synonym: "cytidine diphosphate glucose pyrophosphorylase activity" EXACT [EC:2.7.7.33]
synonym: "cytidine diphosphate-D-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.33]
synonym: "cytidine diphosphoglucose pyrophosphorylase activity" EXACT [EC:2.7.7.33]
xref: EC:2.7.7.33
xref: KEGG:R00956
xref: MetaCyc:2.7.7.33-RXN
xref: RHEA:18216
is_a: GO:0070567 ! cytidylyltransferase activity

[Term]
id: GO:0047344
name: glucose-1-phosphate guanylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate + GTP = diphosphate + GDP-D-glucose." [EC:2.7.7.34, RHEA:10711]
synonym: "GDP glucose pyrophosphorylase activity" EXACT [EC:2.7.7.34]
synonym: "GDP-glucose diphosphorylase activity" EXACT [EC:2.7.7.34]
synonym: "GDP-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.34]
synonym: "GTP:alpha-D-glucose-1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.34]
synonym: "GTP:glucose-1-phosphate guanylyltransferase activity" EXACT []
synonym: "guanosine diphosphoglucose pyrophosphorylase activity" EXACT [EC:2.7.7.34]
xref: EC:2.7.7.34
xref: KEGG:R00954
xref: MetaCyc:2.7.7.34-RXN
xref: RHEA:10711
is_a: GO:0070568 ! guanylyltransferase activity

[Term]
id: GO:0047345
name: ribose-5-phosphate adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-ribose 5-phosphate + ADP + H(+) = ADP-ribose + phosphate." [EC:2.7.7.35, RHEA:14532]
synonym: "adenosine diphosphoribose phosphorylase activity" EXACT [EC:2.7.7.35]
synonym: "ADP ribose phosphorylase activity" EXACT [EC:2.7.7.35]
synonym: "ADP-ribose phosphorylase activity" EXACT [EC:2.7.7.35]
synonym: "ADP:D-ribose-5-phosphate adenylyltransferase activity" EXACT [EC:2.7.7.35]
synonym: "ADP:ribose-5-phosphate adenylyltransferase activity" EXACT []
xref: EC:2.7.7.35
xref: KEGG:R01052
xref: MetaCyc:2.7.7.35-RXN
xref: RHEA:14532
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0047346
name: aldose-1-phosphate adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: aldose 1-phosphate + ADP = phosphate + ADP-aldose." [EC:2.7.7.36, MetaCyc:2.7.7.36-RXN]
synonym: "adenosine diphosphate glucose:orthophosphate adenylyltransferase activity" EXACT [EC:2.7.7.36]
synonym: "adenosine diphosphosugar phosphorylase activity" EXACT [EC:2.7.7.36]
synonym: "ADP sugar phosphorylase activity" EXACT [EC:2.7.7.36]
synonym: "ADP-aldose phosphorylase activity" EXACT [EC:2.7.7.36]
synonym: "ADP-sugar phosphorylase activity" BROAD [EC:2.7.7.36]
synonym: "ADP:aldose-1-phosphate adenylyltransferase activity" EXACT []
synonym: "ADP:alpha-D-aldose-1-phosphate adenylyltransferase activity" EXACT [EC:2.7.7.36]
synonym: "ADPaldose phosphorylase activity" EXACT [EC:2.7.7.36]
synonym: "sugar-1-phosphate adenylyltransferase activity" BROAD [EC:2.7.7.36]
xref: EC:2.7.7.36
xref: MetaCyc:2.7.7.36-RXN
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0047347
name: aldose-1-phosphate nucleotidyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: aldose 1-phosphate + NDP = phosphate + NDP-aldose." [EC:2.7.7.37, MetaCyc:2.7.7.37-RXN]
subset: gosubset_prok
synonym: "glucose 1-phosphate inosityltransferase activity" EXACT [EC:2.7.7.37]
synonym: "NDP sugar phosphorylase activity" EXACT [EC:2.7.7.37]
synonym: "NDP-aldose phosphorylase activity" EXACT [EC:2.7.7.37]
synonym: "NDP-sugar phosphorylase activity" BROAD [EC:2.7.7.37]
synonym: "NDP:aldose-1-phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.37]
synonym: "NDP:alpha-D-aldose-1-phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.37]
synonym: "NDPaldose phosphorylase activity" EXACT [EC:2.7.7.37]
synonym: "nucleoside diphosphate sugar:orthophosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.37]
synonym: "nucleoside diphosphosugar phosphorylase activity" EXACT [EC:2.7.7.37]
synonym: "sugar nucleotide phosphorylase activity" EXACT [EC:2.7.7.37]
synonym: "sugar phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.37]
synonym: "sugar-1-phosphate nucleotidyltransferase activity" BROAD [EC:2.7.7.37]
xref: EC:2.7.7.37
xref: MetaCyc:2.7.7.37-RXN
is_a: GO:0016779 ! nucleotidyltransferase activity

[Term]
id: GO:0047348
name: glycerol-3-phosphate cytidylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: sn-glycerol 3-phosphate + CTP = CDP-glycerol + diphosphate." [EC:2.7.7.39, RHEA:13364]
subset: gosubset_prok
synonym: "CDP-glycerol diphosphorylase activity" EXACT [EC:2.7.7.39]
synonym: "CDP-glycerol pyrophosphorylase activity" EXACT [EC:2.7.7.39]
synonym: "CTP:glycerol 3-phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.39]
synonym: "CTP:glycerol-3-phosphate cytidylyltransferase activity" EXACT []
synonym: "CTP:sn-glycerol-3-phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.39]
synonym: "cytidine diphosphate glycerol pyrophosphorylase activity" EXACT [EC:2.7.7.39]
synonym: "cytidine diphosphoglycerol pyrophosphorylase activity" EXACT [EC:2.7.7.39]
synonym: "Gro-PCT" RELATED [EC:2.7.7.39]
xref: EC:2.7.7.39
xref: KEGG:R00856
xref: MetaCyc:2.7.7.39-RXN
xref: RHEA:13364
is_a: GO:0070567 ! cytidylyltransferase activity

[Term]
id: GO:0047349
name: D-ribitol-5-phosphate cytidylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-ribitol 5-phosphate + CTP = CDP-ribitol + diphosphate." [EC:2.7.7.40, RHEA:12459]
subset: gosubset_prok
synonym: "CDP ribitol pyrophosphorylase activity" EXACT [EC:2.7.7.40]
synonym: "CDP-ribitol diphosphorylase activity" EXACT [EC:2.7.7.40]
synonym: "CDP-ribitol pyrophosphorylase activity" EXACT [EC:2.7.7.40]
synonym: "CTP:D-ribitol-5-phosphate cytidylyltransferase activity" EXACT []
synonym: "cytidine diphosphate ribitol pyrophosphorylase activity" EXACT [EC:2.7.7.40]
synonym: "cytidine diphosphoribitol pyrophosphorylase activity" EXACT [EC:2.7.7.40]
synonym: "ribitol 5-phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.40]
xref: EC:2.7.7.40
xref: KEGG:R02921
xref: MetaCyc:2.7.7.40-RXN
xref: RHEA:12459
is_a: GO:0070567 ! cytidylyltransferase activity

[Term]
id: GO:0047350
name: glucuronate-1-phosphate uridylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-phospho-alpha-D-glucuronate + UTP = diphosphate + UDP-alpha-D-glucuronate." [EC:2.7.7.44, RHEA:16328]
synonym: "UDP-D-glucuronic acid pyrophosphorylase activity" EXACT [EC:2.7.7.44]
synonym: "UDP-glucuronate pyrophosphorylase activity" EXACT [EC:2.7.7.44]
synonym: "UDP-glucuronic acid pyrophosphorylase activity" EXACT [EC:2.7.7.44]
synonym: "uridine diphosphoglucuronic pyrophosphorylase activity" EXACT [EC:2.7.7.44]
synonym: "UTP:1-phospho-alpha-D-glucuronate uridylyltransferase activity" EXACT [EC:2.7.7.44]
synonym: "UTP:glucuronate-1-phosphate uridylyltransferase activity" EXACT []
xref: EC:2.7.7.44
xref: KEGG:R01381
xref: MetaCyc:2.7.7.44-RXN
xref: RHEA:16328
is_a: GO:0070569 ! uridylyltransferase activity

[Term]
id: GO:0047351
name: guanosine-triphosphate guanylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 GTP = P(1),P(4)-bis(5'-guanosyl) tetraphosphate + diphosphate + H(+)." [EC:2.7.7.45, RHEA:18156]
synonym: "GTP:GTP guanylyltransferase activity" BROAD []
xref: EC:2.7.7.45
xref: KEGG:R00012
xref: MetaCyc:2.7.7.45-RXN
xref: RHEA:18156
is_a: GO:0070568 ! guanylyltransferase activity

[Term]
id: GO:0047352
name: adenylylsulfate-ammonia adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5'-adenylyl sulfate + NH(4)(+) = adenosine 5'-phosphoramidate + 2 H(+) + sulfate." [EC:2.7.7.51, RHEA:19200]
synonym: "adenylylsulfate:ammonia adenylyltransferase activity" EXACT [EC:2.7.7.51]
synonym: "adenylylsulphate-ammonia adenylyltransferase activity" EXACT []
synonym: "APSAT" RELATED [EC:2.7.7.51]
xref: EC:2.7.7.51
xref: KEGG:R01619
xref: MetaCyc:2.7.7.51-RXN
xref: RHEA:19200
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0047353
name: N-methylphosphoethanolamine cytidylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-methylethanolamine phosphate + CTP = CDP-N-methylethanolamine + diphosphate." [EC:2.7.7.57, RHEA:10579]
synonym: "CTP:N-methylethanolamine-phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.57]
synonym: "CTP:N-methylphosphoethanolamine cytidylyltransferase activity" EXACT []
synonym: "CTP:P-MEA cytidylyltransferase activity" EXACT [EC:2.7.7.57]
synonym: "monomethylethanolamine phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.57]
xref: EC:2.7.7.57
xref: KEGG:R03375
xref: MetaCyc:2.7.7.57-RXN
xref: RHEA:10579
is_a: GO:0070567 ! cytidylyltransferase activity

[Term]
id: GO:0047354
name: sphingosine cholinephosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CDP-choline + sphingosine = CMP + H(+) + sphingosyl-phosphocholine." [EC:2.7.8.10, RHEA:21227]
synonym: "CDP-choline-sphingosine cholinephosphotransferase activity" EXACT [EC:2.7.8.10]
synonym: "CDP-choline:sphingosine cholinephosphotransferase activity" EXACT [EC:2.7.8.10]
synonym: "cytidine diphosphocholine-sphingosine cholinephosphotransferase activity" EXACT [EC:2.7.8.10]
synonym: "phosphorylcholine-sphingosine transferase activity" EXACT [EC:2.7.8.10]
synonym: "sphingosine choline phosphotransferase activity" EXACT []
xref: EC:2.7.8.10
xref: KEGG:R01929
xref: MetaCyc:2.7.8.10-RXN
xref: RHEA:21227
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0047355
name: CDP-glycerol glycerophosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycerophosphate(n) + CDP-glycerol = glycerophosphate(n+1) + CMP." [EC:2.7.8.12, MetaCyc:2.7.8.12-RXN]
subset: gosubset_prok
synonym: "CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase activity" EXACT [EC:2.7.8.12]
synonym: "CDPglycerol glycerophosphotransferase activity" EXACT [EC:2.7.8.12]
synonym: "CGPTase activity" EXACT [EC:2.7.8.12]
synonym: "cytidine diphosphoglycerol glycerophosphotransferase activity" EXACT [EC:2.7.8.12]
synonym: "glycerophosphate synthetase activity" EXACT [EC:2.7.8.12]
synonym: "poly(glycerol phosphate) polymerase activity" EXACT [EC:2.7.8.12]
synonym: "teichoic acid glycerol transferase activity" EXACT [EC:2.7.8.12]
synonym: "teichoic-acid synthase activity" BROAD [EC:2.7.8.12]
xref: EC:2.7.8.12
xref: MetaCyc:2.7.8.12-RXN
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0047356
name: CDP-ribitol ribitolphosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ribitol phosphate(n) + CDP-ribitol = ribitol phosphate(n+1) + CMP." [EC:2.7.8.14, MetaCyc:2.7.8.14-RXN]
subset: gosubset_prok
synonym: "CDP-ribitol:poly(ribitol phosphate) ribitolphosphotransferase activity" EXACT [EC:2.7.8.14]
synonym: "CDPribitol ribitolphosphotransferase activity" EXACT [EC:2.7.8.14]
synonym: "poly(ribitol phosphate) synthetase activity" EXACT [EC:2.7.8.14]
synonym: "polyribitol phosphate polymerase activity" EXACT [EC:2.7.8.14]
synonym: "polyribitol phosphate synthetase activity" EXACT [EC:2.7.8.14]
synonym: "teichoate synthase activity" EXACT [EC:2.7.8.14]
synonym: "teichoate synthetase activity" EXACT [EC:2.7.8.14]
synonym: "teichoic-acid synthase activity" BROAD [EC:2.7.8.14]
xref: EC:2.7.8.14
xref: MetaCyc:2.7.8.14-RXN
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0047357
name: UDP-galactose-UDP-N-acetylglucosamine galactose phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-alpha-D-glucosamine + UDP-D-galactose = H(+) + UDP-N-acetyl-6-(D-galactose-1-phospho)-D-glucosamine + UMP." [EC:2.7.8.18, RHEA:22443]
synonym: "galactose-1-phosphotransferase activity" EXACT [EC:2.7.8.18]
synonym: "galactosyl phosphotransferase activity" EXACT [EC:2.7.8.18]
synonym: "UDP-galactose:UDP-N-acetyl-D-glucosamine galactose phosphotransferase activity" EXACT [EC:2.7.8.18]
synonym: "UDPgalactose-UDP-N-acetylglucosamine galactose phosphotransferase activity" EXACT [EC:2.7.8.18]
synonym: "UDPgalactose:UDP-N-acetyl-D-glucosamine galactose phosphotransferase activity" EXACT [EC:2.7.8.18]
synonym: "uridine diphosphogalactose-uridine diphosphoacetylglucosamine galactose-1-phosphotransferase activity" EXACT [EC:2.7.8.18]
xref: EC:2.7.8.18
xref: KEGG:R00504
xref: MetaCyc:2.7.8.18-RXN
xref: RHEA:22443
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0047358
name: UDP-glucose-glycoprotein glucose phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycoprotein D-mannose + UDP-D-glucose = glycoprotein 6-(D-glucose-1-phospho)-D-mannose + UMP." [EC:2.7.8.19, MetaCyc:2.7.8.19-RXN]
synonym: "Glc-phosphotransferase activity" EXACT [EC:2.7.8.19]
synonym: "GlcPTase activity" EXACT [EC:2.7.8.19]
synonym: "UDP-glucose:glycoprotein glucose-1-phosphotransferase activity" EXACT [EC:2.7.8.19]
synonym: "UDP-glucose:glycoprotein-D-mannose glucosephosphotransferase activity" EXACT [EC:2.7.8.19]
synonym: "UDPglucose-glycoprotein glucose phosphotransferase activity" EXACT [EC:2.7.8.19]
synonym: "UDPglucose:glycoprotein-D-mannose glucosephosphotransferase activity" EXACT [EC:2.7.8.19]
synonym: "uridine diphosphoglucose-glycoprotein glucose-1-phosphotransferase activity" EXACT [EC:2.7.8.19]
xref: EC:2.7.8.19
xref: MetaCyc:2.7.8.19-RXN
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0047359
name: 1-alkenyl-2-acylglycerol choline phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-alkenyl-2-acylglycerol + CDP-choline = plasmenylcholine + CMP." [EC:2.7.8.22, MetaCyc:2.7.8.22-RXN]
synonym: "CDP-choline-1-alkenyl-2-acyl-glycerol phosphocholinetransferase activity" EXACT [EC:2.7.8.22]
synonym: "CDP-choline:1-alkenyl-2-acylglycerol cholinephosphotransferase activity" EXACT [EC:2.7.8.22]
xref: EC:2.7.8.22
xref: MetaCyc:2.7.8.22-RXN
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0047360
name: undecaprenyl-phosphate galactose phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: all-trans-undecaprenyl phosphate + UDP-D-galactose = alpha-D-galactosyl-diphosphoundecaprenol + UMP." [EC:2.7.8.6, RHEA:11655]
subset: gosubset_prok
synonym: "poly(isoprenol)-phosphate galactose phosphotransferase activity" EXACT [EC:2.7.8.6]
synonym: "poly(isoprenol)-phosphate galactosephosphotransferase activity" EXACT [EC:2.7.8.6]
synonym: "poly(isoprenyl)phosphate galactosephosphatetransferase activity" EXACT [EC:2.7.8.6]
synonym: "UDP-galactose:undecaprenyl-phosphate galactose phosphotransferase activity" EXACT [EC:2.7.8.6]
synonym: "undecaprenyl phosphate galactosyl-1-phosphate transferase activity" EXACT [EC:2.7.8.6]
xref: EC:2.7.8.6
xref: KEGG:R01535
xref: MetaCyc:2.7.8.6-RXN
xref: RHEA:11655
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0047361
name: phosphomannan mannosephosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphomannan(n) + GDP-mannose = phosphomannan(n+1) + GMP." [EC:2.7.8.9, MetaCyc:2.7.8.9-RXN]
synonym: "GDP-mannose:phosphomannan mannose phosphotransferase activity" EXACT [EC:2.7.8.9]
xref: EC:2.7.8.9
xref: MetaCyc:2.7.8.9-RXN
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0047362
name: thiosulfate-dithiol sulfurtransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: dithioerythritol + thiosulfate = hydrogen sulfide + dithioerythritol disulfide + sulfite." [EC:2.8.1.5, MetaCyc:2.8.1.5-RXN]
synonym: "thiosulfate reductase activity" EXACT [EC:2.8.1.5]
synonym: "thiosulfate:dithioerythritol sulfurtransferase activity" EXACT [EC:2.8.1.5]
synonym: "thiosulphate-dithiol sulphurtransferase activity" EXACT []
synonym: "TSR" RELATED [EC:2.8.1.5]
xref: EC:2.8.1.5
xref: MetaCyc:2.8.1.5-RXN
xref: RHEA:15124
is_a: GO:0016783 ! sulfurtransferase activity

[Term]
id: GO:0047363
name: triglucosylalkylacylglycerol sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,3-1-O-alkyl-2-O-acylglycerol + 3'-phosphoadenosine 5'-phosphosulfate = 6-sulfo-alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,3-1-O-alkyl-2-O-acylglycerol + adenosine 3',5'-bisphosphate." [EC:2.8.2.19, MetaCyc:2.8.2.19-RXN]
synonym: "3'-phosphoadenylyl-sulfate:triglucosyl-1-O-alkyl-2-O-acylglycerol 6-sulfotransferase activity" EXACT [EC:2.8.2.19]
synonym: "triglucosylalkylacylglycerol sulphotransferase activity" EXACT []
synonym: "triglucosylmonoalkylmonoacyl sulfotransferase activity" EXACT [EC:2.8.2.19]
xref: EC:2.8.2.19
xref: MetaCyc:2.8.2.19-RXN
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0047364
name: desulfoglucosinolate sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + desulfoglucotropeolin = adenosine 3',5'-diphosphate + glucotropeolin + H(+)." [EC:2.8.2.24, RHEA:20284]
synonym: "3'-phosphoadenosine-5'-phosphosulfate:desulfoglucosinolate sulfotransferase activity" EXACT [EC:2.8.2.24]
synonym: "3'-phosphoadenylyl-sulfate:desulfoglucosinolate sulfotransferase activity" EXACT [EC:2.8.2.24]
synonym: "desulphoglucosinolate sulphotransferase activity" EXACT []
synonym: "PAPS-desulfoglucosinolate sulfotransferase activity" EXACT [EC:2.8.2.24]
xref: EC:2.8.2.24
xref: KEGG:R03214
xref: MetaCyc:2.8.2.24-RXN
xref: RHEA:20284
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0047365
name: quercetin-3-sulfate 3'-sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + quercetin 3-sulfate = adenosine 3',5'-diphosphate + H(+) + quercetin 3,3'-disulfate." [EC:2.8.2.26, RHEA:22507]
synonym: "3'-phosphoadenylyl-sulfate:quercetin-3-sulfate 3'-sulfotransferase activity" EXACT [EC:2.8.2.26]
synonym: "3'-sulfotransferase activity" EXACT [EC:2.8.2.26]
synonym: "flavonol 3'-sulfotransferase activity" EXACT [EC:2.8.2.26]
synonym: "PAPS:flavonol 3-sulfate 3'-sulfotransferase activity" EXACT [EC:2.8.2.26]
synonym: "quercetin-3-sulphate 3'-sulphotransferase activity" EXACT []
xref: EC:2.8.2.26
xref: KEGG:R02632
xref: MetaCyc:2.8.2.26-RXN
xref: RHEA:22507
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0047366
name: quercetin-3-sulfate 4'-sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + quercetin 3-sulfate = adenosine 3',5'-diphosphate + H(+) + quercetin 3,4'-disulfate." [EC:2.8.2.27, RHEA:17208]
synonym: "3'-phosphoadenylyl-sulfate:quercetin-3-sulfate 4'-sulfotransferase activity" EXACT [EC:2.8.2.27]
synonym: "flavonol 4'-sulfotransferase activity" EXACT [EC:2.8.2.27]
synonym: "PAPS:flavonol 3-sulfate 4'-sulfotransferase activity" EXACT [EC:2.8.2.27]
synonym: "quercetin-3-sulphate 4'-sulphotransferase activity" EXACT []
xref: EC:2.8.2.27
xref: KEGG:R02633
xref: MetaCyc:2.8.2.27-RXN
xref: RHEA:17208
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0047367
name: quercetin-3,3'-bissulfate 7-sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: quercetin 3,3'-bissulfate + 3'-phosphoadenosine 5'-phosphosulfate = quercetin 3,3',7-trissulfate + adenosine 3',5'-bisphosphate." [EC:2.8.2.28, MetaCyc:2.8.2.28-RXN]
synonym: "3'-phosphoadenylyl-sulfate:quercetin-3,3'-bissulfate 7-sulfotransferase activity" EXACT [EC:2.8.2.28]
synonym: "7-sulfotransferase activity" EXACT [EC:2.8.2.28]
synonym: "flavonol 7-sulfotransferase activity" EXACT [EC:2.8.2.28]
synonym: "PAPS:flavonol 3,3'/3,4'-disulfate 7-sulfotransferase activity" EXACT [EC:2.8.2.28]
synonym: "quercetin-3,3'-bissulphate 7-sulphotransferase activity" EXACT []
xref: EC:2.8.2.28
xref: MetaCyc:2.8.2.28-RXN
xref: RHEA:21863
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0047368
name: UDP-N-acetylgalactosamine-4-sulfate sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + UDP-N-acetyl-D-galactosamine 4-sulfate = adenosine 3',5'-diphosphate + H(+) + UDP-N-acetyl-D-galactosamine 4,6-disulfate." [EC:2.8.2.7, RHEA:14340]
synonym: "3'-phosphoadenylyl-sulfate:UDP-N-acetyl-D-galactosamine-4-sulfate 6-sulfotransferase activity" EXACT [EC:2.8.2.7]
synonym: "UDP-N-acetylgalactosamine-4-sulphate sulphotransferase activity" EXACT []
synonym: "uridine diphospho-N-acetylgalactosamine 4-sulfate sulfotransferase activity" EXACT [EC:2.8.2.7]
synonym: "uridine diphosphoacetylgalactosamine 4-sulfate sulfotransferase activity" EXACT [EC:2.8.2.7]
xref: EC:2.8.2.7
xref: KEGG:R04476
xref: MetaCyc:2.8.2.7-RXN
xref: RHEA:14340
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0047369
name: succinate-hydroxymethylglutarate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-3-hydroxy-3-methylglutarate + succinyl-CoA = 3-hydroxy-3-methyl-glutaryl-CoA + succinate." [EC:2.8.3.13, MetaCyc:2.8.3.13-RXN]
synonym: "dicarboxyl-CoA:dicarboxylic acid coenzyme A transferase activity" EXACT [EC:2.8.3.13]
synonym: "hydroxymethylglutarate coenzyme A-transferase activity" EXACT [EC:2.8.3.13]
synonym: "succinate:(S)-3-hydroxy-3-methylglutarate CoA-transferase activity" EXACT [EC:2.8.3.13]
xref: EC:2.8.3.13
xref: MetaCyc:2.8.3.13-RXN
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0047370
name: succinate-citramalate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-citramalate + succinyl-CoA = citramalyl-CoA + succinate." [EC:2.8.3.7, MetaCyc:2.8.3.7-RXN]
synonym: "citramalate coenzyme A-transferase activity" EXACT [EC:2.8.3.7]
synonym: "itaconate CoA-transferase activity" EXACT [EC:2.8.3.7]
synonym: "succinyl coenzyme A-citramalyl coenzyme A transferase activity" EXACT [EC:2.8.3.7]
synonym: "succinyl-CoA:citramalate CoA-transferase activity" EXACT [EC:2.8.3.7]
xref: EC:2.8.3.7
xref: MetaCyc:2.8.3.7-RXN
xref: RHEA:23531
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0047371
name: butyrate-acetoacetate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetoacetate + butanoyl-CoA = acetoacetyl-CoA + butanoate." [EC:2.8.3.9, RHEA:12964]
subset: gosubset_prok
synonym: "butanoyl-CoA:acetoacetate CoA-transferase activity" EXACT [EC:2.8.3.9]
synonym: "butyryl coenzyme A-acetoacetate coenzyme A-transferase activity" EXACT [EC:2.8.3.9]
synonym: "butyryl-CoA-acetoacetate CoA-transferase activity" EXACT [EC:2.8.3.9]
xref: EC:2.8.3.9
xref: KEGG:R01365
xref: MetaCyc:2.8.3.9-RXN
xref: RHEA:12964
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0047372
name: acylglycerol lipase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + acylglycerol = a fatty acid + glycerol." [EC:3.1.1.23, MetaCyc:3.1.1.23-RXN]
subset: goslim_chembl
subset: gosubset_prok
synonym: "fatty acyl monoester lipase activity" EXACT [EC:3.1.1.23]
synonym: "glycerol-ester acylhydrolase activity" EXACT [EC:3.1.1.23]
synonym: "monoacylglycerol hydrolase activity" EXACT [EC:3.1.1.23]
synonym: "monoacylglycerol lipase activity" EXACT [EC:3.1.1.23]
synonym: "monoacylglycerolipase activity" EXACT [EC:3.1.1.23]
synonym: "monoglyceridase activity" EXACT [EC:3.1.1.23]
synonym: "monoglyceride hydrolase activity" EXACT [EC:3.1.1.23]
synonym: "monoglyceride lipase activity" EXACT [EC:3.1.1.23]
synonym: "monoglyceridyllipase activity" EXACT [EC:3.1.1.23]
xref: EC:3.1.1.23
xref: MetaCyc:3.1.1.23-RXN
xref: Reactome:REACT_100140 "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase), Gallus gallus"
xref: Reactome:REACT_100448 "Digestion of diacylglycerols by extracellular PTL:colipase, Taeniopygia guttata"
xref: Reactome:REACT_100782 "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase), Bos taurus"
xref: Reactome:REACT_101036 "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase), Danio rerio"
xref: Reactome:REACT_102360 "2-acylglycerol + H2O -> glycerol + fatty acid, Canis familiaris"
xref: Reactome:REACT_103536 "2-AG hydrolysis to arachidonate by MAGL, Schizosaccharomyces pombe"
xref: Reactome:REACT_103689 "Digestion of diacylglycerols by extracellular PTL:colipase, Mus musculus"
xref: Reactome:REACT_104272 "2-acylglycerol + H2O -> glycerol + fatty acid, Dictyostelium discoideum"
xref: Reactome:REACT_104481 "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase), Rattus norvegicus"
xref: Reactome:REACT_105008 "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase), Rattus norvegicus"
xref: Reactome:REACT_106113 "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase), Mus musculus"
xref: Reactome:REACT_106352 "2-AG hydrolysis to arachidonate by MAGL, Xenopus tropicalis"
xref: Reactome:REACT_106907 "2-AG hydrolysis to arachidonate by MAGL, Gallus gallus"
xref: Reactome:REACT_107190 "2-acylglycerol + H2O -> glycerol + fatty acid, Mycobacterium tuberculosis"
xref: Reactome:REACT_107266 "Digestion of triacylglycerols by extracellular PTL:colipase, Bos taurus"
xref: Reactome:REACT_107746 "2-AG hydrolysis to arachidonate by MAGL, Rattus norvegicus"
xref: Reactome:REACT_107847 "Digestion of diacylglycerols by extracellular PTL:colipase, Canis familiaris"
xref: Reactome:REACT_107870 "DAG is metabolized by DAGL to 2-AG, Mus musculus"
xref: Reactome:REACT_108459 "DAG is metabolized by DAGL to 2-AG, Bos taurus"
xref: Reactome:REACT_108633 "Digestion of diacylglycerols by extracellular PTL:colipase, Rattus norvegicus"
xref: Reactome:REACT_109762 "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase), Danio rerio"
xref: Reactome:REACT_109931 "2-AG hydrolysis to arachidonate by MAGL, Saccharomyces cerevisiae"
xref: Reactome:REACT_112247 "Digestion of diacylglycerols by extracellular PTL:colipase, Xenopus tropicalis"
xref: Reactome:REACT_112520 "DAG is metabolized by DAGL to 2-AG, Arabidopsis thaliana"
xref: Reactome:REACT_112608 "2-AG hydrolysis to arachidonate by MAGL, Arabidopsis thaliana"
xref: Reactome:REACT_112674 "DAG is metabolized by DAGL to 2-AG, Oryza sativa"
xref: Reactome:REACT_113210 "Digestion of triacylglycerols by extracellular PTL:colipase, Gallus gallus"
xref: Reactome:REACT_113735 "2-acylglycerol + H2O -> glycerol + fatty acid, Arabidopsis thaliana"
xref: Reactome:REACT_114438 "2-acylglycerol + H2O -> glycerol + fatty acid, Staphylococcus aureus N315"
xref: Reactome:REACT_114496 "Digestion of triacylglycerols by extracellular PTL:colipase, Xenopus tropicalis"
xref: Reactome:REACT_114762 "Digestion of diacylglycerols by extracellular PTL:colipase, Gallus gallus"
xref: Reactome:REACT_114842 "2-acylglycerol + H2O -> glycerol + fatty acid, Oryza sativa"
xref: Reactome:REACT_115057 "2-AG hydrolysis to arachidonate by MAGL, Staphylococcus aureus N315"
xref: Reactome:REACT_115200 "2-AG hydrolysis to arachidonate by MAGL, Oryza sativa"
xref: Reactome:REACT_115325 "DAG is metabolized by DAGL to 2-AG, Caenorhabditis elegans"
xref: Reactome:REACT_19135 "DAG is metabolized by DAGL to 2-AG, Homo sapiens"
xref: Reactome:REACT_19155 "2-AG hydrolysis to arachidonate by MAGL, Homo sapiens"
xref: Reactome:REACT_2017 "2-acylglycerol + H2O -> glycerol + fatty acid, Rattus norvegicus"
xref: Reactome:REACT_28317 "DAG is metabolized by DAGL to 2-AG, Canis familiaris"
xref: Reactome:REACT_28378 "Digestion of triacylglycerols by extracellular PTL:colipase, Taeniopygia guttata"
xref: Reactome:REACT_28451 "2-AG hydrolysis to arachidonate by MAGL, Bos taurus"
xref: Reactome:REACT_29329 "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase), Bos taurus"
xref: Reactome:REACT_30437 "Digestion of triacylglycerols by extracellular PTL:colipase, Mus musculus"
xref: Reactome:REACT_30947 "Digestion of triacylglycerols by extracellular PTL:colipase, Canis familiaris"
xref: Reactome:REACT_31803 "2-AG hydrolysis to arachidonate by MAGL, Danio rerio"
xref: Reactome:REACT_31882 "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase), Canis familiaris"
xref: Reactome:REACT_33472 "2-acylglycerol + H2O -> glycerol + fatty acid, Xenopus tropicalis"
xref: Reactome:REACT_33717 "DAG is metabolized by DAGL to 2-AG, Drosophila melanogaster"
xref: Reactome:REACT_33722 "Digestion of diacylglycerols by extracellular PTL:colipase, Sus scrofa"
xref: Reactome:REACT_34461 "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase), Mus musculus"
xref: Reactome:REACT_594 "2-acylglycerol + H2O -> glycerol + fatty acid, Homo sapiens"
xref: Reactome:REACT_77077 "2-AG hydrolysis to arachidonate by MAGL, Taeniopygia guttata"
xref: Reactome:REACT_78957 "2-acylglycerol + H2O -> glycerol + fatty acid, Mus musculus"
xref: Reactome:REACT_79441 "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase), Taeniopygia guttata"
xref: Reactome:REACT_79543 "2-acylglycerol + H2O -> glycerol + fatty acid, Taeniopygia guttata"
xref: Reactome:REACT_81812 "2-AG hydrolysis to arachidonate by MAGL, Dictyostelium discoideum"
xref: Reactome:REACT_81944 "Digestion of triacylglycerols by extracellular PTL:colipase, Rattus norvegicus"
xref: Reactome:REACT_82735 "DAG is metabolized by DAGL to 2-AG, Rattus norvegicus"
xref: Reactome:REACT_83703 "2-acylglycerol + H2O -> glycerol + fatty acid, Danio rerio"
xref: Reactome:REACT_85221 "DAG is metabolized by DAGL to 2-AG, Gallus gallus"
xref: Reactome:REACT_85539 "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase), Gallus gallus"
xref: Reactome:REACT_87188 "Digestion of triacylglycerols by extracellular PTL:colipase, Sus scrofa"
xref: Reactome:REACT_87496 "DAG is metabolized by DAGL to 2-AG, Sus scrofa"
xref: Reactome:REACT_88280 "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase), Xenopus tropicalis"
xref: Reactome:REACT_90857 "2-acylglycerol + H2O -> glycerol + fatty acid, Schizosaccharomyces pombe"
xref: Reactome:REACT_91226 "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase), Taeniopygia guttata"
xref: Reactome:REACT_92458 "DAG is metabolized by DAGL to 2-AG, Xenopus tropicalis"
xref: Reactome:REACT_92811 "DAG is metabolized by DAGL to 2-AG, Danio rerio"
xref: Reactome:REACT_9389 "Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2, Homo sapiens"
xref: Reactome:REACT_9412 "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase), Homo sapiens"
xref: Reactome:REACT_94131 "2-acylglycerol + H2O -> glycerol + fatty acid, Saccharomyces cerevisiae"
xref: Reactome:REACT_9457 "Digestion of diacylglycerols by extracellular PTL:colipase, Homo sapiens"
xref: Reactome:REACT_9501 "Digestion of triacylglycerols by extracellular PTL:colipase, Homo sapiens"
xref: Reactome:REACT_9502 "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase), Homo sapiens"
xref: Reactome:REACT_96506 "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase), Xenopus tropicalis"
xref: Reactome:REACT_97548 "DAG is metabolized by DAGL to 2-AG, Taeniopygia guttata"
xref: Reactome:REACT_97648 "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase), Canis familiaris"
xref: Reactome:REACT_97903 "2-AG hydrolysis to arachidonate by MAGL, Mus musculus"
xref: Reactome:REACT_98049 "2-acylglycerol + H2O -> glycerol + fatty acid, Bos taurus"
xref: Reactome:REACT_98154 "2-AG hydrolysis to arachidonate by MAGL, Mycobacterium tuberculosis"
xref: Reactome:REACT_98390 "2-acylglycerol + H2O -> glycerol + fatty acid, Gallus gallus"
xref: Reactome:REACT_99097 "2-AG hydrolysis to arachidonate by MAGL, Canis familiaris"
xref: Reactome:REACT_99807 "Digestion of diacylglycerols by extracellular PTL:colipase, Bos taurus"
is_a: GO:0016298 ! lipase activity
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0047373
name: acetoxybutynylbithiophene deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene + H(2)O = 5-(4-hydroxy-but-1-ynyl)-2,2'-bithiophene + acetate + H(+)." [EC:3.1.1.54, RHEA:11551]
synonym: "5-(4-acetoxy-1-butynyl)-2,2'-bithiophene:acetate esterase activity" EXACT [EC:3.1.1.54]
synonym: "5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene O-acetylhydrolase activity" EXACT [EC:3.1.1.54]
synonym: "acetoxybutynylbithiophene esterase activity" EXACT [EC:3.1.1.54]
xref: EC:3.1.1.54
xref: KEGG:R04490
xref: MetaCyc:3.1.1.54-RXN
xref: RHEA:11551
is_a: GO:0019213 ! deacetylase activity
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0047374
name: methylumbelliferyl-acetate deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-methylumbelliferyl acetate + H(2)O = 4-methylumbelliferone + acetate + H(+)." [EC:3.1.1.56, RHEA:12211]
synonym: "4-methylumbelliferyl-acetate acylhydrolase activity" EXACT [EC:3.1.1.56]
synonym: "esterase D activity" RELATED [EC:3.1.1.56]
xref: EC:3.1.1.56
xref: KEGG:R04141
xref: MetaCyc:3.1.1.56-RXN
xref: RHEA:12211
is_a: GO:0019213 ! deacetylase activity
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0047375
name: N-acetylgalactosaminoglycan deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + N-acetyl-D-galactosaminoglycan = acetate + D-galactosaminoglycan." [EC:3.1.1.58, MetaCyc:3.1.1.58-RXN]
synonym: "N-acetyl galactosaminoglycan deacetylase activity" EXACT [EC:3.1.1.58]
synonym: "N-acetyl-D-galactosaminoglycan acetylhydrolase activity" EXACT [EC:3.1.1.58]
synonym: "polysaccharide deacetylase activity" EXACT [EC:3.1.1.58]
synonym: "Vi-polysaccharide deacetylase activity" EXACT [EC:3.1.1.58]
xref: EC:3.1.1.58
xref: MetaCyc:3.1.1.58-RXN
is_a: GO:0019213 ! deacetylase activity
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0047376
name: all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity
namespace: molecular_function
def: "Catalysis of the reaction: all-trans-retinyl palmitate + H2O = all-trans-retinol + H+ + palmitate." [MetaCyc:3.1.1.64-RXN, RHEA:13936]
synonym: "all-trans-retinyl-palmitate acylhydrolase activity" BROAD [EC:3.1.1.64]
synonym: "all-trans-retinyl-palmitate hydrolase activity" BROAD [EC:3.1.1.64]
synonym: "retinyl-palmitate palmitohydrolase activity" BROAD [KEGG:R02368]
xref: EC:3.1.1.-
xref: KEGG:R02368
xref: MetaCyc:3.1.1.64-RXN
xref: RHEA:13936
is_a: GO:0052689 ! carboxylic ester hydrolase activity
relationship: part_of GO:0042572 ! retinol metabolic process

[Term]
id: GO:0047377
name: 5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene + H(2)O = 5-(3-hydroxy-4-acetoxybut-1-ynyl)-2,2'-bithiophene + acetate + H(+)." [EC:3.1.1.66, RHEA:16316]
synonym: "3,4-diacetoxybutinylbithiophene:4-acetate esterase activity" EXACT [EC:3.1.1.66]
synonym: "5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene acetylhydrolase activity" EXACT [EC:3.1.1.66]
synonym: "diacetoxybutynylbithiophene acetate esterase activity" EXACT [EC:3.1.1.66]
xref: EC:3.1.1.66
xref: KEGG:R04525
xref: MetaCyc:3.1.1.66-RXN
xref: RHEA:16316
is_a: GO:0019213 ! deacetylase activity
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0047378
name: acetylalkylglycerol acetylhydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycerol + H(2)O = 1-alkyl-sn-glycerol + acetate + H(+)." [EC:3.1.1.71, RHEA:11555]
synonym: "2-acetyl-1-alkyl-sn-glycerol acetylhydrolase activity" EXACT [EC:3.1.1.71]
synonym: "alkylacetylglycerol acetylhydrolase activity" EXACT [EC:3.1.1.71]
xref: EC:3.1.1.71
xref: KEGG:R04043
xref: MetaCyc:3.1.1.71-RXN
xref: RHEA:11555
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0047379
name: ADP-dependent short-chain-acyl-CoA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + a short-chain acyl-CoA = a short-chain carboxylate + CoA." [EC:3.1.2.18, MetaCyc:3.1.2.18-RXN]
synonym: "ADP-dependent propionyl coenzyme A hydrolase activity" NARROW [EC:3.1.2.18]
synonym: "ADP-dependent propionyl-CoA hydrolase activity" NARROW [EC:3.1.2.18]
synonym: "ADP-dependent propionyl-CoA thioesterase activity" NARROW [EC:3.1.2.18]
synonym: "ADP-dependent short-chain acyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.18]
synonym: "ADP-dependent short-chain acyl-CoA hydrolase activity" EXACT [EC:3.1.2.18]
synonym: "ADP-dependent short-chain acyl-CoA thioesterase activity" EXACT [EC:3.1.2.18]
synonym: "ADP-dependent-short-chain-acyl-CoA hydrolase activity" EXACT [EC:3.1.2.18]
xref: EC:3.1.2.18
xref: MetaCyc:3.1.2.18-RXN
is_a: GO:0047617 ! acyl-CoA hydrolase activity

[Term]
id: GO:0047380
name: ADP-dependent medium-chain-acyl-CoA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + a medium-chain acyl-CoA = a medium-chain carboxylate + CoA. Requires ADP." [EC:3.1.2.19, MetaCyc:3.1.2.19-RXN]
subset: gosubset_prok
synonym: "ADP-dependent medium-chain acyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.19]
synonym: "ADP-dependent medium-chain acyl-CoA hydrolase activity" EXACT [EC:3.1.2.19]
synonym: "ADP-dependent medium-chain acyl-thioester hydrolase activity" EXACT [EC:3.1.2.19]
synonym: "ADP-dependent medium-chain hydrolase activity" EXACT [EC:3.1.2.19]
synonym: "ADP-dependent myristoyl-CoA thioesterase activity" NARROW [EC:3.1.2.19]
synonym: "ADP-dependent-medium-chain-acyl-CoA hydrolase activity" EXACT [EC:3.1.2.19]
xref: EC:3.1.2.19
xref: MetaCyc:3.1.2.19-RXN
is_a: GO:0052815 ! medium-chain acyl-CoA hydrolase activity

[Term]
id: GO:0047381
name: dodecanoyl-[acyl-carrier-protein] hydrolase activity
namespace: molecular_function
alt_id: GO:0016294
def: "Catalysis of the reaction: H2O + dodecanoyl-[acyl-carrier protein] = dodecanoate + [acyl-carrier protein]." [EC:3.1.2.21, MetaCyc:3.1.2.21-RXN]
synonym: "dodecanoyl-[acyl-carrier protein] hydrolase activity" EXACT []
synonym: "dodecanoyl-ACP hydrolase activity" EXACT []
synonym: "dodecanoyl-acyl-carrier-protein hydrolase activity" EXACT [EC:3.1.2.21]
synonym: "dodecyl-[acyl-carrier protein] hydrolase activity" EXACT [EC:3.1.2.21]
synonym: "dodecyl-acyl-carrier protein hydrolase" BROAD [EC:3.1.2.21]
synonym: "lauroyl-[acyl-carrier-protein] hydrolase activity" EXACT []
synonym: "lauroyl-ACP hydrolase activity" EXACT []
synonym: "lauryl-[acyl-carrier protein] hydrolase activity" EXACT [EC:3.1.2.21]
synonym: "lauryl-acyl-carrier protein hydrolase activity" EXACT [EC:3.1.2.21]
synonym: "lauryl-acyl-carrier-protein hydrolase activity" EXACT [EC:3.1.2.21]
xref: EC:3.1.2.21
xref: MetaCyc:3.1.2.21-RXN
is_a: GO:0016297 ! acyl-[acyl-carrier-protein] hydrolase activity

[Term]
id: GO:0047382
name: methylphosphothioglycerate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-methyl-3-phospho-1-thio-D-glycerate + H(2)O = S-methyl-1-thio-D-glycerate + phosphate." [EC:3.1.3.14, RHEA:16084]
synonym: "methylthiophosphoglycerate phosphatase activity" EXACT [EC:3.1.3.14]
synonym: "S-methyl-3-phospho-1-thio-D-glycerate phosphohydrolase activity" EXACT [EC:3.1.3.14]
xref: EC:3.1.3.14
xref: KEGG:R04317
xref: MetaCyc:3.1.3.14-RXN
xref: RHEA:16084
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0047383
name: guanidinodeoxy-scyllo-inositol-4-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H(2)O = 1-guanidino-1-deoxy-scyllo-inositol + phosphate." [EC:3.1.3.40, RHEA:15780]
synonym: "1-guanidino-1-deoxy-scyllo-inositol-4-P phosphohydrolase activity" EXACT [EC:3.1.3.40]
synonym: "1-guanidino-1-deoxy-scyllo-inositol-4-phosphate 4-phosphohydrolase activity" EXACT [EC:3.1.3.40]
synonym: "1-guanidino-scyllo-inositol 4-phosphatase activity" EXACT [EC:3.1.3.40]
xref: EC:3.1.3.40
xref: KEGG:R03496
xref: MetaCyc:3.1.3.40-RXN
xref: RHEA:15780
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0047384
name: [hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate = phosphate + [hydroxymethylglutaryl-CoA reductase (NADPH)]." [EC:3.1.3.47, MetaCyc:3.1.3.47-RXN]
synonym: "hydroxymethylglutaryl-CoA reductase (NADPH)-phosphatase activity" EXACT [EC:3.1.3.47]
synonym: "hydroxymethylglutaryl-CoA reductase (NADPH)-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.47]
synonym: "reductase phosphatase activity" BROAD [EC:3.1.3.47]
xref: EC:3.1.3.47
xref: MetaCyc:3.1.3.47-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0047385
name: [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate = phosphate + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]." [EC:3.1.3.52, MetaCyc:3.1.3.52-RXN]
synonym: "3-methyl-2-oxobutanoate dehydrogenase (lipoamide)-phosphatase activity" EXACT [EC:3.1.3.52]
synonym: "3-methyl-2-oxobutanoate dehydrogenase (lipoamide)-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.52]
synonym: "branched-chain 2-keto acid dehydrogenase phosphatase activity" EXACT [EC:3.1.3.52]
synonym: "branched-chain alpha-keto acid dehydrogenase phosphatase" BROAD [EC:3.1.3.52]
synonym: "branched-chain oxo-acid dehydrogenase phosphatase activity" RELATED [EC:3.1.3.52]
xref: EC:3.1.3.52
xref: MetaCyc:3.1.3.52-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0047386
name: fructose-2,6-bisphosphate 6-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-D-fructose 2,6-bisphosphate + H(2)O = beta-D-fructofuranose 2-phosphate + phosphate." [EC:3.1.3.54, RHEA:13336]
synonym: "beta-D-fructose-2,6-bisphosphate 6-phosphohydrolase activity" EXACT [EC:3.1.3.54]
synonym: "D-fructose-2,6-bisphosphate 6-phosphohydrolase activity" EXACT [EC:3.1.3.54]
synonym: "fructose 2,6-bisphosphate-6-phosphohydrolase activity" EXACT [EC:3.1.3.54]
synonym: "fructose-2,6-bisphosphate 6-phosphohydrolase activity" EXACT [EC:3.1.3.54]
xref: EC:3.1.3.54
xref: KEGG:R02730
xref: MetaCyc:3.1.3.54-RXN
xref: RHEA:13336
is_a: GO:0050308 ! sugar-phosphatase activity

[Term]
id: GO:0047387
name: serine-ethanolaminephosphate phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + serine phosphoethanolamine = H(+) + phosphoethanolamine + serine." [EC:3.1.4.13, RHEA:17116]
subset: gosubset_prok
synonym: "SEP diesterase activity" EXACT [EC:3.1.4.13]
synonym: "serine ethanolamine phosphodiester phosphodiesterase activity" EXACT [EC:3.1.4.13]
synonym: "serine-phosphoethanolamine ethanolaminephosphohydrolase activity" EXACT [EC:3.1.4.13]
xref: EC:3.1.4.13
xref: KEGG:R02817
xref: MetaCyc:3.1.4.13-RXN
xref: RHEA:17116
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0047388
name: adenylyl-[glutamate-ammonia ligase] hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: adenylyl-[L-glutamate:ammonia ligase (ADP-forming)] + H2O = AMP + [L-glutamate:ammonia ligase (ADP-forming)]." [EC:3.1.4.15, MetaCyc:3.1.4.15-RXN]
synonym: "adenylyl(glutamine synthetase) hydrolase activity" EXACT [EC:3.1.4.15]
synonym: "adenylyl-glutamate-ammonia ligase hydrolase activity" EXACT [EC:3.1.4.15]
synonym: "adenylyl-glutamine-synthetasehydrolase activity" EXACT [EC:3.1.4.15]
synonym: "adenylyl-L-glutamate:ammonia ligase (ADP-forming) adenylylhydrolase activity" EXACT [EC:3.1.4.15]
xref: EC:3.1.4.15
xref: KEGG:R03474
xref: MetaCyc:3.1.4.15-RXN
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0047389
name: glycerophosphocholine phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + L-1-glycero-3-phosphocholine = glycerol-3-phosphate + choline." [EC:3.1.4.2, MetaCyc:3.1.4.2-RXN]
subset: gosubset_prok
synonym: "glycerolphosphorylcholine phosphodiesterase activity" EXACT [EC:3.1.4.2]
synonym: "glycerophosphinicocholine diesterase activity" EXACT [EC:3.1.4.2]
synonym: "glycerophosphohydrolase activity" EXACT [EC:3.1.4.2]
synonym: "glycerylphosphorylcholinediesterase activity" EXACT [EC:3.1.4.2]
synonym: "sn-glycero-3-phosphocholine glycerophosphohydrolase activity" EXACT [EC:3.1.4.2]
synonym: "sn-glycero-3-phosphorylcholine diesterase activity" EXACT [EC:3.1.4.2]
xref: EC:3.1.4.2
xref: MetaCyc:3.1.4.2-RXN
xref: RHEA:16064
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0047390
name: glycerophosphocholine cholinephosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: sn-glycero-3-phosphocholine + H(2)O = choline phosphate + glycerol + H(+)." [EC:3.1.4.38, RHEA:19548]
synonym: "L-3-glycerylphosphinicocholine cholinephosphohydrolase activity" EXACT [EC:3.1.4.38]
synonym: "sn-glycero-3-phosphocholine cholinephosphohydrolase activity" EXACT [EC:3.1.4.38]
xref: EC:3.1.4.38
xref: KEGG:R02591
xref: MetaCyc:3.1.4.38-RXN
xref: RHEA:19548
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0047391
name: alkylglycerophosphoethanolamine phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + 1-alkyl-sn-glycero-3-phosphoethanolamine = ethanolamine + 1-alkyl-sn-glycerol 3-phosphate." [EC:3.1.4.39, MetaCyc:3.1.4.39-RXN]
synonym: "1-alkyl-sn-glycero-3-phosphoethanolamine ethanolaminehydrolase activity" EXACT [EC:3.1.4.39]
synonym: "lysophospholipase D activity" RELATED [EC:3.1.4.39]
xref: EC:3.1.4.39
xref: MetaCyc:3.1.4.39-RXN
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0047392
name: CMP-N-acylneuraminate phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + CMP-N-acylneuraminate = N-acylneuraminate + CMP." [EC:3.1.4.40, MetaCyc:3.1.4.40-RXN]
synonym: "CMP-N-acetylneuraminate hydrolase activity" EXACT [EC:3.1.4.40]
synonym: "CMP-N-acylneuraminate N-acylneuraminohydrolase activity" EXACT [EC:3.1.4.40]
synonym: "CMP-N-acylneuraminic acid hydrolase activity" EXACT [EC:3.1.4.40]
synonym: "CMP-sialate hydrolase activity" EXACT [EC:3.1.4.40]
synonym: "CMP-sialic acid hydrolase activity" EXACT [EC:3.1.4.40]
synonym: "cytidine monophosphate-N-acetylneuraminic acid hydrolase activity" EXACT [EC:3.1.4.40]
synonym: "cytidine monophosphosialate hydrolase activity" EXACT [EC:3.1.4.40]
synonym: "cytidine monophosphosialic hydrolase activity" EXACT [EC:3.1.4.40]
xref: EC:3.1.4.40
xref: MetaCyc:3.1.4.40-RXN
xref: RHEA:20188
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0047393
name: glycerol-1,2-cyclic-phosphate 2-phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycerol 1,2-cyclic phosphate + H(2)O = glycerol 1-phosphate + H(+)." [EC:3.1.4.42, RHEA:16496]
synonym: "rac-glycerol 1:2-cyclic phosphate 2-phosphodiesterase activity" EXACT [EC:3.1.4.42]
synonym: "rac-glycerol-1,2-cyclic-phosphate 2-glycerophosphohydrolase activity" EXACT [EC:3.1.4.42]
xref: EC:3.1.4.42
xref: KEGG:R02648
xref: MetaCyc:3.1.4.42-RXN
xref: RHEA:16496
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0047394
name: glycerophosphoinositol inositolphosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + 1-(sn-glycero-3-phospho)-1D-myoinositol = 1D-myo-inositol 1-phosphate + glycerol." [EC:3.1.4.43, MetaCyc:3.1.4.43-RXN]
subset: gosubset_prok
synonym: "1,2-cyclic-inositol-phosphate phosphodiesterase activity" EXACT []
synonym: "1-(sn-glycero-3-phospho)-1D-myo-inositol inositolphosphohydrolase activity" EXACT [EC:3.1.4.43]
synonym: "1-D-myo-inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase activity" EXACT [EC:3.1.4.43]
synonym: "D-inositol 1,2-cyclic phosphate 2-phosphohydrolase activity" EXACT [EC:3.1.4.43]
synonym: "D-myo-inositol 1,2-cyclic phosphate 2-phosphohydrolase activity" EXACT [EC:3.1.4.43]
synonym: "D-myo-inositol 1:2-cyclic phosphate 2-phosphohydrolase activity" EXACT [EC:3.1.4.43]
synonym: "inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase activity" EXACT [EC:3.1.4.43]
xref: EC:3.1.4.43
xref: MetaCyc:3.1.4.43-RXN
xref: RHEA:14036
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0047395
name: glycerophosphoinositol glycerophosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-(sn-glycero-3-phospho)-1D-myo-inositol + H(2)O = sn-glycerol 3-phosphate + myo-inositol + H(+)." [EC:3.1.4.44, RHEA:16504]
synonym: "1-(sn-glycero-3-phospho)-1D-myo-inositol glycerophosphohydrolase activity" EXACT [EC:3.1.4.44]
synonym: "sn-glycero(3)phosphoinositol glycerophosphohydrolase activity" EXACT [EC:3.1.4.44]
synonym: "sn-glycero-3-phospho-1-inositol glycerophosphohydrolase activity" EXACT [EC:3.1.4.44]
xref: EC:3.1.4.44
xref: KEGG:R01193
xref: MetaCyc:3.1.4.44-RXN
xref: RHEA:16504
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0047396
name: glycosylphosphatidylinositol diacylglycerol-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol = 1,2-diacyl-sn-glycerol + 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate." [EC:4.6.1.14, MetaCyc:3.1.4.47-RXN]
subset: gosubset_prok
synonym: "(glycosyl)phosphatidylinositol-specific phospholipase C activity" EXACT [EC:4.6.1.14]
synonym: "6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol diacyl-sn-glycerol-lyase [6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate-forming]" RELATED [EC:4.6.1.14]
synonym: "6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase (1,2-cyclic-phosphate-forming) activity" EXACT [EC:4.6.1.14]
synonym: "glycosyl inositol phospholipid anchor-hydrolyzing enzyme activity" EXACT [EC:4.6.1.14]
synonym: "glycosylphosphatidylinositol-phospholipase C activity" NARROW [EC:4.6.1.14]
synonym: "glycosylphosphatidylinositol-specific phospholipase C activity" EXACT [EC:4.6.1.14]
synonym: "GPI-PLC activity" EXACT [EC:4.6.1.14]
synonym: "GPI-specific phospholipase C activity" EXACT [EC:4.6.1.14]
synonym: "variant-surface-glycoprotein phospholipase C activity" EXACT []
synonym: "VSG-lipase activity" EXACT [EC:4.6.1.14]
xref: EC:4.6.1.14
xref: MetaCyc:3.1.4.47-RXN
xref: RHEA:14336
is_a: GO:0009975 ! cyclase activity
is_a: GO:0016849 ! phosphorus-oxygen lyase activity

[Term]
id: GO:0047397
name: dolichylphosphate-glucose phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: dolichyl beta-D-glucosyl phosphate + H2O = dolichol-phosphate + beta-D-glucose." [EC:3.1.4.48, MetaCyc:3.1.4.48-RXN]
synonym: "Dol-P-Glc phosphodiesterase activity" EXACT [EC:3.1.4.48]
synonym: "dolichol phosphoglucose phosphodiesterase activity" EXACT [EC:3.1.4.48]
synonym: "dolichyl-beta-D-glucosyl-phosphate dolichylphosphohydrolase activity" EXACT [EC:3.1.4.48]
synonym: "dolichyl-phosphate-glucose phosphodiesterase activity" EXACT []
xref: EC:3.1.4.48
xref: MetaCyc:3.1.4.48-RXN
xref: RHEA:13860
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0047398
name: dolichylphosphate-mannose phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: dolichyl beta-D-mannosyl phosphate + H2O = dolichol-phosphate + mannose." [EC:3.1.4.49, MetaCyc:3.1.4.49-RXN]
synonym: "dolichyl-beta-D-mannosyl-phosphate dolichylphosphohydrolase activity" EXACT [EC:3.1.4.49]
synonym: "mannosylphosphodolichol phosphodiesterase activity" EXACT [EC:3.1.4.49]
xref: EC:3.1.4.49
xref: MetaCyc:3.1.4.49-RXN
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0047399
name: glucose-1-phospho-D-mannosylglycoprotein phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + 6-(D-glucose-1-phospho)-D-mannosylglycoprotein = D-mannosylglycoprotein + D-glucose-alpha-1-phosphate." [EC:3.1.4.51, MetaCyc:3.1.4.51-RXN]
synonym: "6-(D-glucose-1-phospho)-D-mannosylglycoprotein glucose-1-phosphohydrolase activity" EXACT [EC:3.1.4.51]
synonym: "alpha-glucose-1-phosphate phosphodiesterase activity" EXACT [EC:3.1.4.51]
xref: EC:3.1.4.51
xref: MetaCyc:3.1.4.51-RXN
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0047400
name: phosphonoacetate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + phosphonoacetate = acetate + H(+) + phosphate." [EC:3.11.1.2, RHEA:16752]
synonym: "phosphonoacetate phosphonohydrolase activity" EXACT [EC:3.11.1.2]
xref: EC:3.11.1.2
xref: KEGG:R00318
xref: MetaCyc:3.11.1.2-RXN
xref: RHEA:16752
is_a: GO:0016827 ! hydrolase activity, acting on acid carbon-phosphorus bonds

[Term]
id: GO:0047401
name: trithionate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + trithionate = H(+) + sulfate + thiosulfate." [EC:3.12.1.1, RHEA:21887]
synonym: "trithionate thiosulfohydrolase activity" EXACT [EC:3.12.1.1]
xref: EC:3.12.1.1
xref: KEGG:R01930
xref: MetaCyc:3.12.1.1-RXN
xref: RHEA:21887
is_a: GO:0016828 ! hydrolase activity, acting on acid sulfur-sulfur bonds

[Term]
id: GO:0047402
name: protein-glucosylgalactosylhydroxylysine glucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + protein alpha-D-glucosyl-1,2-beta-D-galactosyl-L-hydroxylysine = protein beta-D-galactosyl-L-hydroxylysine + beta-D-glucose." [EC:3.2.1.107, MetaCyc:3.2.1.107-RXN]
synonym: "2-O-alpha-D-glucopyranosyl-5-O-alpha-D-galactopyranosylhydroxy-L-lysine glucohydrolase activity" EXACT [EC:3.2.1.107]
synonym: "protein-alpha-D-glucosyl-1,2-beta-D-galactosyl-L-hydroxylysine glucohydrolase activity" EXACT [EC:3.2.1.107]
xref: EC:3.2.1.107
xref: MetaCyc:3.2.1.107-RXN
is_a: GO:0015926 ! glucosidase activity

[Term]
id: GO:0047403
name: lacto-N-biosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + beta-D-Gal-(1,3)-beta-D-GlcNAc-(1,3)-beta-D-Gal-(1,4)-D-Glc = beta-D-Gal-(1,4)-D-Glc + beta-D-Gal-(1,3)-D-GlcNAc." [EC:3.2.1.140, MetaCyc:3.2.1.140-RXN]
synonym: "oligosaccharide lacto-N-biosylhydrolase activity" RELATED [EC:3.2.1.140]
xref: EC:3.2.1.140
xref: RHEA:21571
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0047404
name: glucuronosyl-disulfoglucosamine glucuronidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + 3-D-glucuronosyl-N2-,6-disulfo-beta-D-glucosamine = glucuronate + N2,6-disulfo-D-glucosamine." [EC:3.2.1.56, MetaCyc:3.2.1.56-RXN]
synonym: "3-D-glucuronsyl-2-N,6-disulfo-beta-D-glucosamine glucuronohydrolase activity" EXACT [EC:3.2.1.56]
synonym: "3-D-glucuronsyl-N2,6-disulfo-beta-D-glucosamine glucuronohydrolase activity" EXACT [EC:3.2.1.56]
synonym: "glucuronosyl-disulphoglucosamine glucuronidase activity" EXACT []
xref: EC:3.2.1.56
xref: MetaCyc:3.2.1.56-RXN
xref: RHEA:15076
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0047405
name: pyrimidine-5'-nucleotide nucleosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + a pyrimidine 5'-nucleotide = ribose-5-phosphate + a pyrimidine." [EC:3.2.2.10, MetaCyc:3.2.2.10-RXN]
synonym: "Pyr5N activity" EXACT [EC:3.2.2.10]
synonym: "pyrimidine nucleotide N-ribosidase activity" EXACT [EC:3.2.2.10]
synonym: "pyrimidine-5'-nucleotide phosphoribo(deoxyribo)hydrolase activity" EXACT [EC:3.2.2.10]
xref: EC:3.2.2.10
xref: MetaCyc:3.2.2.10-RXN
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0047406
name: beta-aspartyl-N-acetylglucosaminidase activity
namespace: molecular_function
def: "Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H(2)O = N-acetyl-D-glucosamine + L-asparagine." [EC:3.2.2.11, RHEA:12327]
synonym: "1-beta-aspartyl-N-acetyl-D-glucosaminylamine L-asparaginohydrolase activity" EXACT [EC:3.2.2.11]
synonym: "beta-aspartylacetylglucosaminidase activity" EXACT [EC:3.2.2.11]
xref: EC:3.2.2.11
xref: KEGG:R01266
xref: MetaCyc:3.2.2.11-RXN
xref: RHEA:12327
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0047407
name: ADP-ribosyl-[dinitrogen reductase] hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: ADP-ribosyl-[dinitrogen reductase] = adenosine diphosphate ribose + [dinitrogen reductase]." [EC:3.2.2.24, MetaCyc:3.2.2.24-RXN]
subset: gosubset_prok
synonym: "ADP-D-ribosyl-dinitrogen reductase ADP-ribosylhydrolase activity" EXACT [EC:3.2.2.24]
synonym: "ADP-ribosyl glycohydrolase activity" EXACT [EC:3.2.2.24]
synonym: "ADP-ribosyl-dinitrogen reductase hydrolase activity" EXACT [EC:3.2.2.24]
synonym: "azoferredoxin glycosidase activity" EXACT [EC:3.2.2.24]
synonym: "azoferredoxin-activating enzymes" RELATED [EC:3.2.2.24]
synonym: "dinitrogenase reductase activating glycohydrolase activity" RELATED [EC:3.2.2.24]
synonym: "dinitrogenase reductase-activating glycohydrolase activity" EXACT [EC:3.2.2.24]
xref: EC:3.2.2.24
xref: MetaCyc:3.2.2.24-RXN
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0047408
name: alkenylglycerophosphocholine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + 1-(1-alkenyl)-sn-glycero-3-phosphocholine = L-1-glycero-3-phosphocholine + an aldehyde." [EC:3.3.2.2, MetaCyc:3.3.2.2-RXN]
synonym: "1-(1-alkenyl)-sn-glycero-3-phosphocholine aldehydohydrolase activity" EXACT [EC:3.3.2.2]
synonym: "lysoplasmalogenase activity" EXACT [EC:3.3.2.2]
xref: EC:3.3.2.2
xref: MetaCyc:3.3.2.2-RXN
is_a: GO:0016803 ! ether hydrolase activity

[Term]
id: GO:0047409
name: alkenylglycerophosphoethanolamine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + 1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine = sn-glycero-3-phosphoethanolamine + an aldehyde." [EC:3.3.2.5, MetaCyc:3.3.2.5-RXN]
synonym: "1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine aldehydohydrolase activity" EXACT [EC:3.3.2.5]
xref: EC:3.3.2.5
xref: MetaCyc:3.3.2.5-RXN
is_a: GO:0016803 ! ether hydrolase activity

[Term]
id: GO:0047410
name: N-formylmethionylaminoacyl-tRNA deformylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + charged-fMet-tRNAs = L-methionylaminoacyl-tRNA + formate." [EC:3.5.1.27, MetaCyc:3.5.1.27-RXN]
synonym: "N-formyl-L-methionylaminoacyl-tRNA amidohydrolase activity" EXACT [EC:3.5.1.27]
xref: EC:3.5.1.27
xref: MetaCyc:3.5.1.27-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047411
name: 2-(acetamidomethylene)succinate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 H2O + 2-(acetamidomethylene)succinate = CO2 + NH3 + succinate semialdehyde + acetate." [EC:3.5.1.29, MetaCyc:3.5.1.29-RXN]
synonym: "2-(acetamidomethylene)succinate amidohydrolase (deaminating, decarboxylating)" EXACT [EC:3.5.1.29]
synonym: "alpha-(N-acetylaminomethylene)succinic acid hydrolase activity" EXACT [EC:3.5.1.29]
xref: EC:3.5.1.29
xref: MetaCyc:3.5.1.29-RXN
xref: RHEA:10435
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047412
name: N-(long-chain-acyl)ethanolamine deacylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + N-(long-chain-acyl)ethanolamine = ethanolamine + a fatty acid." [EC:3.5.1.60, MetaCyc:3.5.1.60-RXN]
synonym: "acylethanolamine amidase activity" EXACT []
synonym: "N-(long-chain-acyl)ethanolamine amidohydrolase activity" EXACT []
synonym: "N-acylethanolamine amidohydrolase activity" EXACT []
xref: EC:3.5.1.60
xref: MetaCyc:3.5.1.60-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047413
name: N(alpha)-benzyloxycarbonylleucine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-benzyloxycarbonyl-L-leucine + H(2)O + H(+) = L-leucine + benzyl alcohol + CO(2)." [EC:3.5.1.64, RHEA:18904]
synonym: "alpha-N-benzyloxycarbonyl-L-leucine urethanehydrolase activity" EXACT [EC:3.5.1.64]
synonym: "benzyloxycarbonylleucine hydrolase activity" EXACT [EC:3.5.1.64]
synonym: "nalpha-benzyloxycarbonyl amino acid urethane hydrolase IV" RELATED [EC:3.5.1.64]
synonym: "nalpha-benzyloxycarbonyl-L-leucine urethanehydrolase activity" EXACT [EC:3.5.1.64]
synonym: "nalpha-benzyloxycarbonylleucine hydrolase activity" EXACT [EC:3.5.1.64]
xref: EC:3.5.1.64
xref: KEGG:R02552
xref: MetaCyc:3.5.1.64-RXN
xref: RHEA:18904
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047414
name: 2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2Z)-2-(acetamidomethylene)-3-(hydroxymethyl)succinate + 2 H(2)O + H(+) = 2-(hydroxymethyl)-4-oxobutanoate + acetate + CO(2) + NH(4)(+)." [EC:3.5.1.66, RHEA:17680]
synonym: "2-(hydroxymethyl)-3-(acetamidomethylene)succinate amidohydrolase (deaminating, decarboxylating)" EXACT [EC:3.5.1.66]
synonym: "alpha-hydroxymethyl-alpha'-(N-acetylaminomethylene)succinic acid hydrolase activity" EXACT [EC:3.5.1.66]
synonym: "compound B hydrolase activity" EXACT [EC:3.5.1.66]
xref: EC:3.5.1.66
xref: KEGG:R04397
xref: MetaCyc:3.5.1.66-RXN
xref: RHEA:17680
xref: Wikipedia:2-(hydroxymethyl)-3-(acetamidomethylene)succinate_amidohydrolase_(deaminating\,_decarboxylating)
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047415
name: D-benzoylarginine-4-nitroanilide amidase activity
namespace: molecular_function
def: "Catalysis of the reaction: N(2)-benzoyl-D-arginine-4-nitroanilide + H(2)O = 4-nitroaniline + N(2)-benzoyl-D-arginine + H(+)." [EC:3.5.1.72, RHEA:14424]
synonym: "benzoyl-D-arginine arylamidase activity" EXACT [EC:3.5.1.72]
synonym: "D-BAPA-ase activity" EXACT [EC:3.5.1.72]
synonym: "N-benzoyl-D-arginine-4-nitroanilide amidohydrolase activity" EXACT [EC:3.5.1.72]
xref: EC:3.5.1.72
xref: KEGG:R04113
xref: MetaCyc:3.5.1.72-RXN
xref: RHEA:14424
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047416
name: arylalkyl acylamidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + N-acetylarylalkylamine = acetate + arylalkylamine." [EC:3.5.1.76, MetaCyc:3.5.1.76-RXN]
subset: gosubset_prok
synonym: "aralkyl acylamidase activity" EXACT [EC:3.5.1.76]
synonym: "N-acetylarylalkylamine amidohydrolase activity" EXACT [EC:3.5.1.76]
xref: EC:3.5.1.76
xref: MetaCyc:3.5.1.76-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047417
name: N-carbamoyl-D-amino acid hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + N-carbamoyl-D-amino acid = CO2 + NH3 + D-amino acid." [EC:3.5.1.77, MetaCyc:3.5.1.77-RXN]
subset: gosubset_prok
synonym: "N-carbamoyl-D-amino acid amidohydrolase activity" EXACT [EC:3.5.1.77]
xref: EC:3.5.1.77
xref: MetaCyc:3.5.1.77-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047418
name: phthalyl amidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + a phthalylamide = phthalate + substituted amine." [EC:3.5.1.79, MetaCyc:3.5.1.79-RXN]
synonym: "o-phthalyl amidase activity" NARROW [EC:3.5.1.79]
synonym: "phthalyl-amide amidohydrolase activity" EXACT [EC:3.5.1.79]
xref: EC:3.5.1.79
xref: MetaCyc:3.5.1.79-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047419
name: N-acetylgalactosamine-6-phosphate deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + N-acetyl-D-galactosamine 6-phosphate = acetate + D-galactosamine 6-phosphate." [EC:3.5.1.-, MetaCyc:3.5.1.80-RXN]
xref: EC:3.5.1.-
xref: MetaCyc:3.5.1.80-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0019213 ! deacetylase activity

[Term]
id: GO:0047420
name: N-acyl-D-amino-acid deacylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + N-acyl-D-amino acid = D-amino acid + an acid." [EC:3.5.1.81, MetaCyc:3.5.1.81-RXN]
subset: gosubset_prok
synonym: "D-aminoacylase activity" EXACT [EC:3.5.1.81]
synonym: "N-acyl-D-amino acid amidohydrolase activity" EXACT [EC:3.5.1.81]
xref: EC:3.5.1.81
xref: MetaCyc:3.5.1.81-RXN
xref: RHEA:18312
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047421
name: N-acyl-D-glutamate deacylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acyl-D-glutamate + H(2)O = D-glutamate + a carboxylate." [EC:3.5.1.82, RHEA:12836]
subset: gosubset_prok
synonym: "N-acyl-D-glutamate amidohydrolase activity" EXACT [EC:3.5.1.82]
xref: EC:3.5.1.82
xref: KEGG:R01581
xref: MetaCyc:3.5.1.82-RXN
xref: RHEA:12836
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047422
name: N-acyl-D-aspartate deacylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acyl-D-aspartate + H(2)O = D-aspartate + a carboxylate." [EC:3.5.1.83, RHEA:18288]
subset: gosubset_prok
synonym: "N-acyl-D-aspartate amidohydrolase activity" EXACT [EC:3.5.1.83]
xref: EC:3.5.1.83
xref: KEGG:R02182
xref: MetaCyc:3.5.1.83-RXN
xref: RHEA:18288
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047423
name: N-methylhydantoinase (ATP-hydrolyzing) activity
namespace: molecular_function
def: "Catalysis of the reaction: N-methylhydantoin + ATP + 2 H(2)O = N-carbamoylsarcosine + ADP + 3 H(+) + phosphate." [EC:3.5.2.14, RHEA:11723]
subset: gosubset_prok
synonym: "methylhydantoin amidase activity" EXACT [EC:3.5.2.14]
synonym: "N-methylhydantoin amidohydrolase activity" EXACT [EC:3.5.2.14]
synonym: "N-methylhydantoin hydrolase activity" EXACT [EC:3.5.2.14]
synonym: "N-methylhydantoinase (ATP-hydrolysing)" EXACT [EC:3.5.2.14]
synonym: "N-methylhydantoinase activity" EXACT [EC:3.5.2.14]
synonym: "N-methylimidazolidine-2,4-dione amidohydrolase (ATP-hydrolysing)" EXACT [EC:3.5.2.14]
xref: EC:3.5.2.14
xref: KEGG:R03187
xref: MetaCyc:3.5.2.14-RXN
xref: RHEA:11723
xref: Wikipedia:N-methylhydantoinase_(ATP-hydrolysing)
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0047424
name: methylenediurea deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 H2O + methylenediurea = CO2 + 2 NH3 + N-hydroxymethylurea." [EC:3.5.3.21, MetaCyc:3.5.3.21-RXN]
subset: gosubset_prok
synonym: "methylenediurea aminohydrolase activity" EXACT [EC:3.5.3.21]
synonym: "methylenediurease activity" EXACT [EC:3.5.3.21]
xref: EC:3.5.3.21
xref: MetaCyc:3.5.3.21-RXN
xref: RHEA:24651
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0047425
name: 1-pyrroline-4-hydroxy-2-carboxylate deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxy-1-pyrroline-2-carboxylate + H(2)O + H(+) = 2,5-dioxopentanoate + NH(4)(+)." [EC:3.5.4.22, RHEA:10563]
synonym: "1-pyrroline-4-hydroxy-2-carboxylate aminohydrolase (decyclizing)" EXACT [EC:3.5.4.22]
synonym: "HPC deaminase activity" EXACT [EC:3.5.4.22]
xref: EC:3.5.4.22
xref: KEGG:R02280
xref: MetaCyc:3.5.4.22-RXN
xref: RHEA:10563
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0047426
name: ricinine nitrilase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + ricinine = NH3 + 3-carboxy-4-methoxy-N-methyl-2-pyridone." [EC:3.5.5.2, MetaCyc:3.5.5.2-RXN]
synonym: "ricinine aminohydrolase activity" EXACT [EC:3.5.5.2]
xref: EC:3.5.5.2
xref: MetaCyc:3.5.5.2-RXN
xref: RHEA:22707
is_a: GO:0000257 ! nitrilase activity

[Term]
id: GO:0047427
name: cyanoalanine nitrilase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-cyano-L-alanine + 2 H(2)O + H(+) = L-aspartate + NH(4)(+)." [EC:3.5.5.4, RHEA:25310]
synonym: "3-cyano-L-alanine aminohydrolase activity" EXACT [EC:3.5.5.4]
synonym: "beta-cyanoalanine nitrilase activity" EXACT [EC:3.5.5.4]
xref: EC:3.5.5.4
xref: KEGG:R00486
xref: MetaCyc:3.5.5.4-RXN
xref: RHEA:25310
is_a: GO:0000257 ! nitrilase activity

[Term]
id: GO:0047428
name: arylacetonitrilase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 H2O + 4-chlorophenylacetonitrile = 4-chlorophenylacetate + NH3." [EC:3.5.5.5, MetaCyc:3.5.5.5-RXN]
synonym: "arylacetonitrile aminohydrolase activity" EXACT [EC:3.5.5.5]
xref: EC:3.5.5.5
xref: MetaCyc:3.5.5.5-RXN
xref: RHEA:20660
is_a: GO:0000257 ! nitrilase activity

[Term]
id: GO:0047429
name: nucleoside-triphosphate diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + a nucleoside triphosphate = diphosphate + a nucleotide." [EC:3.6.1.19, MetaCyc:3.6.1.19-RXN]
subset: gosubset_prok
synonym: "nucleoside-triphosphate diphosphohydrolase activity" EXACT [EC:3.6.1.19]
synonym: "nucleoside-triphosphate pyrophosphatase activity" EXACT []
xref: EC:3.6.1.19
xref: MetaCyc:3.6.1.19-RXN
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0047430
name: oligosaccharide-diphosphodolichol diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + oligosaccharide-diphosphodolichol = dolichol-phosphate + oligosaccharide phosphate." [EC:3.6.1.44, MetaCyc:3.6.1.44-RXN]
synonym: "oligosaccharide-diphosphodolichol phosphodolichohydrolase activity" EXACT [EC:3.6.1.44]
synonym: "oligosaccharide-diphosphodolichol pyrophosphatase activity" EXACT []
xref: EC:3.6.1.44
xref: MetaCyc:3.6.1.44-RXN
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0047431
name: 3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-hydroxy-6-methylpyridine-3,4-dicarboxylate + H(+) = 5-hydroxy-6-methylpyridine-3-carboxylate + CO(2)." [EC:4.1.1.51, RHEA:13672]
synonym: "3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-carboxy-lyase (3-hydroxy-2-methylpyridine-5-carboxylate-forming)" EXACT [EC:4.1.1.51]
synonym: "3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-carboxy-lyase activity" EXACT [EC:4.1.1.51]
xref: EC:4.1.1.51
xref: KEGG:R03461
xref: MetaCyc:4.1.1.51-RXN
xref: RHEA:13672
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047432
name: 2,2-dialkylglycine decarboxylase (pyruvate) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,2-dialkylglycine + H(+) + pyruvate = L-alanine + CO(2) + dialkyl ketone." [EC:4.1.1.64, RHEA:16076]
subset: gosubset_prok
synonym: "2,2-dialkyl-2-amino acid-pyruvate aminotransferase activity" EXACT [EC:4.1.1.64]
synonym: "2,2-dialkylglycine carboxy-lyase (amino-transferring)" EXACT [EC:4.1.1.64]
synonym: "2,2-dialkylglycine carboxy-lyase (amino-transferring; L-alanine-forming)" EXACT [EC:4.1.1.64]
synonym: "alpha-dialkyl amino acid transaminase activity" EXACT [EC:4.1.1.64]
synonym: "dialkyl amino acid (pyruvate) decarboxylase activity" EXACT [EC:4.1.1.64]
synonym: "dialkylamino-acid decarboxylase (pyruvate)" EXACT [EC:4.1.1.64]
synonym: "L-alanine-alpha-ketobutyrate aminotransferase activity" EXACT [EC:4.1.1.64]
xref: EC:4.1.1.64
xref: KEGG:R03854
xref: MetaCyc:4.1.1.64-RXN
xref: RHEA:16076
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047433
name: branched-chain-2-oxoacid decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-3-methyl-2-oxopentanoate + H(+) = 2-methylbutanal + CO(2)." [EC:4.1.1.72, RHEA:21111]
synonym: "(3S)-3-methyl-2-oxopentanoate carboxy-lyase (2-methylbutanal-forming)" EXACT [EC:4.1.1.72]
synonym: "(3S)-3-methyl-2-oxopentanoate carboxy-lyase activity" EXACT [EC:4.1.1.72]
synonym: "BCKA" RELATED [EC:4.1.1.72]
synonym: "branched-chain alpha-keto acid decarboxylase activity" EXACT [EC:4.1.1.72]
synonym: "branched-chain keto acid decarboxylase activity" EXACT [EC:4.1.1.72]
synonym: "branched-chain oxo acid decarboxylase activity" EXACT [EC:4.1.1.72]
xref: EC:4.1.1.72
xref: KEGG:R03894
xref: MetaCyc:4.1.1.72-RXN
xref: RHEA:21111
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047434
name: indolepyruvate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: indolepyruvate = CO2 + indole acetaldehyde." [EC:4.1.1.74, MetaCyc:4.1.1.74-RXN]
subset: gosubset_prok
synonym: "3-(indol-3-yl)pyruvate carboxy-lyase [(2-indol-3-yl)acetaldehyde-forming]" RELATED [EC:4.1.1.74]
synonym: "3-(indol-3-yl)pyruvate carboxy-lyase activity" EXACT [EC:4.1.1.74]
synonym: "indol-3-yl-pyruvate carboxy-lyase activity" EXACT [EC:4.1.1.74]
synonym: "indole-3-pyruvate decarboxylase activity" EXACT [EC:4.1.1.74]
xref: EC:4.1.1.74
xref: MetaCyc:4.1.1.74-RXN
xref: RHEA:18020
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047435
name: 5-guanidino-2-oxopentanoate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-guanidino-2-oxopentanoate + H(+) = 4-guanidinobutanal + CO(2)." [EC:4.1.1.75, RHEA:11343]
synonym: "2-oxo-5-guanidinopentanoate carboxy-lyase (4-guanidinobutanal-forming)" EXACT [EC:4.1.1.75]
synonym: "2-oxo-5-guanidinopentanoate carboxy-lyase activity" EXACT [EC:4.1.1.75]
synonym: "2-oxo-5-guanidinopentanoate decarboxylase activity" EXACT [EC:4.1.1.75]
synonym: "2-oxo-5-guanidinovalerate alpha-ketoarginine decarboxylase activity" EXACT [EC:4.1.1.75]
synonym: "alpha-ketoarginine decarboxylase activity" EXACT [EC:4.1.1.75]
xref: EC:4.1.1.75
xref: KEGG:R03178
xref: MetaCyc:4.1.1.75-RXN
xref: RHEA:11343
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047436
name: arylmalonate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-aryl-2-methylmalonate + H(+) = 2-arylpropionate + CO(2)." [EC:4.1.1.76, RHEA:20516]
subset: gosubset_prok
synonym: "2-aryl-2-methylmalonate carboxy-lyase (2-arylpropanoate-forming)" EXACT [EC:4.1.1.76]
synonym: "2-aryl-2-methylmalonate carboxy-lyase activity" EXACT [EC:4.1.1.76]
synonym: "AMDASE" RELATED [EC:4.1.1.76]
synonym: "AMDase activity" EXACT [EC:4.1.1.76]
xref: EC:4.1.1.76
xref: KEGG:R05173
xref: MetaCyc:4.1.1.76-RXN
xref: RHEA:20516
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047437
name: 4-oxalocrotonate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-oxalocrotonate = CO2 + 2-oxopent-4-enoate." [EC:4.1.1.77, MetaCyc:4.1.1.77-RXN]
subset: gosubset_prok
synonym: "4-oxalocrotonate carboxy-lyase (2-oxopent-4-enoate-forming)" EXACT [EC:4.1.1.77]
synonym: "4-oxalocrotonate carboxy-lyase activity" EXACT [EC:4.1.1.77]
xref: EC:4.1.1.77
xref: MetaCyc:4.1.1.77-RXN
xref: RHEA:24263
xref: UM-BBD_reactionID:r1435
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047438
name: 2-dehydro-3-deoxy-L-pentonate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-dehydro-3-deoxy-L-pentonate = glycolaldehyde + pyruvate." [EC:4.1.2.18, MetaCyc:4.1.2.18-RXN]
synonym: "2-dehydro-3-deoxy-L-pentonate glycolaldehyde-lyase (pyruvate-forming)" EXACT [EC:4.1.2.18]
synonym: "2-dehydro-3-deoxy-L-pentonate glycolaldehyde-lyase activity" EXACT [EC:4.1.2.18]
synonym: "2-keto-3-deoxy-D-xylonate aldolase activity" EXACT [EC:4.1.2.18]
synonym: "2-keto-3-deoxy-L-arabonate aldolase activity" NARROW [EC:4.1.2.18]
synonym: "2-keto-3-deoxy-L-pentonate aldolase activity" EXACT [EC:4.1.2.18]
synonym: "3-deoxy-D-pentulosonic acid aldolase" BROAD [EC:4.1.2.18]
xref: EC:4.1.2.18
xref: MetaCyc:4.1.2.18-RXN
xref: RHEA:18548
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0047439
name: 3-deoxy-D-manno-octulosonate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-deoxy-D-manno-octulosonate = D-arabinose + pyruvate." [EC:4.1.2.23, RHEA:23343]
synonym: "2-keto-3-deoxyoctonate aldolase activity" EXACT [EC:4.1.2.23]
synonym: "2-keto-3-deoxyoctonic aldolase activity" EXACT [EC:4.1.2.23]
synonym: "3-deoxy-D-manno-octulosonate D-arabinose-lyase (pyruvate-forming)" EXACT [EC:4.1.2.23]
synonym: "3-deoxy-D-manno-octulosonate D-arabinose-lyase activity" EXACT [EC:4.1.2.23]
synonym: "3-deoxy-D-manno-octulosonic aldolase activity" EXACT [EC:4.1.2.23]
synonym: "3-deoxyoctulosonic aldolase activity" EXACT [EC:4.1.2.23]
synonym: "KDOaldolase activity" EXACT [EC:4.1.2.23]
xref: EC:4.1.2.23
xref: KEGG:R01576
xref: MetaCyc:4.1.2.23-RXN
xref: RHEA:23343
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0047440
name: 2-dehydro-3-deoxy-D-pentonate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-dehydro-3-deoxy-D-arabinonate = glycolaldehyde + pyruvate." [EC:4.1.2.28, RHEA:20612]
synonym: "2-dehydro-3-deoxy-D-pentonate glycolaldehyde-lyase activity" EXACT [EC:4.1.2.28]
synonym: "2-keto-3-deoxy-D-pentonate aldolase activity" EXACT [EC:4.1.2.28]
synonym: "3-deoxy-D-pentulosonic acid aldolase" BROAD [EC:4.1.2.28]
xref: EC:4.1.2.28
xref: KEGG:R01782
xref: MetaCyc:4.1.2.28-RXN
xref: RHEA:20612
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0047441
name: 5-dehydro-2-deoxyphosphogluconate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-phospho-5-dehydro-2-deoxy-D-gluconate = 3-oxopropanoate + glycerone phosphate." [EC:4.1.2.29, RHEA:13180]
synonym: "5-dehydro-2-deoxy-D-gluconate-6-phosphate malonate-semialdehyde-lyase (pyruvate-forming)" EXACT [EC:4.1.2.29]
synonym: "5-dehydro-2-deoxy-D-gluconate-6-phosphate malonate-semialdehyde-lyase activity" EXACT [EC:4.1.2.29]
synonym: "phospho-5-dehydro-2-deoxygluconate aldolase activity" EXACT [EC:4.1.2.29]
synonym: "phospho-5-keto-2-deoxygluconate aldolase activity" EXACT [EC:4.1.2.29]
xref: EC:4.1.2.29
xref: KEGG:R05378
xref: MetaCyc:4.1.2.29-RXN
xref: RHEA:13180
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0047442
name: 17-alpha-hydroxyprogesterone aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 17-alpha-hydroxyprogesterone = acetaldehyde + 4-androstene-3,17-dione." [EC:4.1.2.30, MetaCyc:4.1.2.30-RXN]
synonym: "17-alpha-hydroxyprogesterone acetaldehyde-lyase activity" EXACT [EC:4.1.2.30]
synonym: "17alpha-hydroxyprogesterone acetaldehyde-lyase (4-androstene-3,17-dione-forming)" EXACT [EC:4.1.2.30]
synonym: "17alpha-hydroxyprogesterone acetaldehyde-lyase activity" EXACT [EC:4.1.2.30]
synonym: "17alpha-hydroxyprogesterone aldolase activity" EXACT [EC:4.1.2.30]
synonym: "C-17/C-20 lyase activity" EXACT [EC:4.1.2.30]
xref: EC:4.1.2.30
xref: MetaCyc:4.1.2.30-RXN
xref: RHEA:14756
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0047443
name: 4-hydroxy-4-methyl-2-oxoglutarate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate." [EC:4.1.3.17, MetaCyc:4.1.3.17-RXN]
subset: gosubset_prok
synonym: "4-hydroxy-4-methyl-2-ketoglutarate aldolase activity" EXACT [EC:4.1.3.17]
synonym: "4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase (pyruvate-forming)" EXACT [EC:4.1.3.17]
synonym: "4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase activity" EXACT [EC:4.1.3.17]
synonym: "gamma-methyl-gamma-hydroxy-alpha-ketoglutaric aldolase activity" EXACT [EC:4.1.3.17]
synonym: "pyruvate aldolase activity" EXACT [EC:4.1.3.17]
xref: EC:4.1.3.17
xref: MetaCyc:4.1.3.17-RXN
xref: RHEA:22751
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0047444
name: N-acylneuraminate-9-phosphate synthase activity
namespace: molecular_function
alt_id: GO:0019007
def: "Catalysis of the reaction: H2O + phosphoenolpyruvate + N-acyl-D-mannosamine 6-phosphate = phosphate + N-acylneuraminate 9-phosphate." [EC:2.5.1.57, MetaCyc:4.1.3.20-RXN]
synonym: "N-acetylneuraminate 9-phosphate lyase activity" EXACT [EC:2.5.1.57]
synonym: "N-acetylneuraminate 9-phosphate sialic acid 9-phosphate synthase activity" EXACT [EC:2.5.1.57]
synonym: "N-acetylneuraminate 9-phosphate synthetase activity" EXACT [EC:2.5.1.57]
synonym: "N-acetylneuraminic acid phosphate synthase activity" EXACT [GOC:mah]
synonym: "N-acylneuraminate-9-phosphate pyruvate-lyase (pyruvate-phosphorylating) activity" EXACT [EC:2.5.1.57]
synonym: "phosphoenolpyruvate:N-acyl-D-mannosamine-6-phosphate 1-(2-carboxy-2-oxoethyl)transferase activity" EXACT [EC:2.5.1.57]
synonym: "sialic acid 9-phosphate synthetase activity" EXACT [EC:2.5.1.57]
xref: EC:2.5.1.57
xref: MetaCyc:4.1.3.20-RXN
xref: RHEA:13424
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0047445
name: 3-hydroxy-3-isohexenylglutaryl-CoA lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA + 4 H(+) = 7-methyl-3-oxooct-6-enoyl-CoA + acetate." [EC:4.1.3.26, RHEA:23087]
synonym: "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA acetate-lyase (7-methyl-3-oxooct-6-enoyl-CoA-forming)" EXACT [EC:4.1.3.26]
synonym: "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA acetate-lyase activity" EXACT [EC:4.1.3.26]
synonym: "3-hydroxy-3-isohexenylglutaryl coenzyme A lyase activity" EXACT [EC:4.1.3.26]
synonym: "3-hydroxy-3-isohexenylglutaryl-CoA isopentenylacetoacetyl-CoA-lyase activity" EXACT [EC:4.1.3.26]
synonym: "beta-hydroxy-beta-isohexenylglutaryl CoA-lyase activity" EXACT [EC:4.1.3.26]
synonym: "hydroxyisohexenylglutaryl-CoA:acetatelyase activity" EXACT [EC:4.1.3.26]
xref: EC:4.1.3.26
xref: KEGG:R08090
xref: MetaCyc:4.1.3.26-RXN
xref: RHEA:23087
xref: UM-BBD_reactionID:r1168
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0047446
name: (1-hydroxycyclohexan-1-yl)acetyl-CoA lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: (1-hydroxycyclohexan-1-yl)acetyl-CoA = acetyl-CoA + cyclohexanone." [EC:4.1.3.35, RHEA:23871]
synonym: "(1-hydroxycyclohexan-1-yl)acetyl-CoA cyclohexanone-lyase (acetyl-CoA-forming)" EXACT [EC:4.1.3.35]
synonym: "(1-hydroxycyclohexan-1-yl)acetyl-CoA cyclohexanone-lyase activity" EXACT [EC:4.1.3.35]
xref: EC:4.1.3.35
xref: KEGG:R02232
xref: MetaCyc:4.1.3.35-RXN
xref: RHEA:23871
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0047447
name: erythro-3-hydroxyaspartate ammonia-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: erythro-3-hydroxy-L-aspartate = NH3 + oxaloacetic acid." [EC:4.3.1.20, MetaCyc:4.3.1.20-RXN]
synonym: "3-hydroxyaspartate dehydratase activity" BROAD [EC:4.3.1.20]
synonym: "erythro-3-hydroxy-L(s)-aspartate hydro-lyase (deaminating) activity" EXACT [EC:4.3.1.20]
synonym: "erythro-3-hydroxy-Ls-aspartate ammonia-lyase (oxaloacetate-forming)" EXACT [EC:4.3.1.20]
synonym: "erythro-3-hydroxy-Ls-aspartate ammonia-lyase activity" EXACT [EC:4.3.1.20]
synonym: "erythro-3-hydroxy-Ls-aspartate hydro-lyase (deaminating)" EXACT [EC:4.3.1.20]
synonym: "erythro-3-hydroxyaspartate dehydratase activity" EXACT []
synonym: "erythro-beta-hydroxyaspartate dehydratase activity" EXACT [EC:4.3.1.20]
xref: EC:4.3.1.20
xref: MetaCyc:4.3.1.20-RXN
xref: RHEA:19760
is_a: GO:0016841 ! ammonia-lyase activity

[Term]
id: GO:0047448
name: 5-dehydro-4-deoxyglucarate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-dehydro-4-deoxy-D-glucarate + H(+) = 2,5-dioxopentanoate + CO(2) + H(2)O." [EC:4.2.1.41, RHEA:24611]
subset: gosubset_prok
synonym: "5-dehydro-4-deoxy-D-glucarate hydro-lyase (decarboxylating)" EXACT [EC:4.2.1.41]
synonym: "5-dehydro-4-deoxy-D-glucarate hydro-lyase (decarboxylating; 2,5-dioxopentanoate-forming)" EXACT [EC:4.2.1.41]
synonym: "5-keto-4-deoxy-glucarate dehydratase activity" EXACT [EC:4.2.1.41]
synonym: "D-4-deoxy-5-ketoglucarate hydro-lyase activity" EXACT [EC:4.2.1.41]
synonym: "deoxyketoglucarate dehydratase activity" EXACT [EC:4.2.1.41]
xref: EC:4.2.1.41
xref: KEGG:R02279
xref: MetaCyc:4.2.1.41-RXN
xref: RHEA:24611
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047449
name: 2-dehydro-3-deoxy-L-arabinonate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-dehydro-3-deoxy-L-arabinonate = 2,5-dioxopentanoate + H(2)O." [EC:4.2.1.43, RHEA:17204]
synonym: "2-dehydro-3-deoxy-L-arabinonate hydro-lyase (2,5-dioxopentanoate-forming)" EXACT [EC:4.2.1.43]
synonym: "2-dehydro-3-deoxy-L-arabinonate hydro-lyase activity" EXACT [EC:4.2.1.43]
synonym: "2-keto-3-deoxy-L-arabinonate dehydratase activity" EXACT [EC:4.2.1.43]
xref: EC:4.2.1.43
xref: KEGG:R02278
xref: MetaCyc:4.2.1.43-RXN
xref: RHEA:17204
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047450
name: crotonoyl-[acyl-carrier-protein] hydratase activity
namespace: molecular_function
alt_id: GO:0080063
def: "Catalysis of the reaction: (3R)-3-hydroxybutanoyl-[acyl-carrier protein] = H2O + but-2-enoyl-[acyl-carrier protein]." [EC:4.2.1.58, MetaCyc:4.2.1.58-RXN]
synonym: "(3R)-3-hydroxybutanoyl-[acyl-carrier-protein] hydro-lyase activity" EXACT [EC:4.2.1.58]
synonym: "(3R)-3-hydroxybutanoyl-acyl-carrier-protein hydro-lyase (but-2-enoyl-acyl-carrier protein-forming)" EXACT [EC:4.2.1.58]
synonym: "(3R)-3-hydroxybutanoyl-acyl-carrier-protein hydro-lyase activity" EXACT [EC:4.2.1.58]
synonym: "3-hydroxybutyryl acyl carrier protein dehydratase activity" EXACT [EC:4.2.1.58]
synonym: "beta-hydroxybutyryl acyl carrier protein (ACP) dehydrase activity" EXACT [EC:4.2.1.58]
synonym: "beta-hydroxybutyryl acyl carrier protein dehydrase activity" EXACT [EC:4.2.1.58]
synonym: "crotonoyl-[acyl-carrier protein] hydratase activity" EXACT []
synonym: "crotonoyl-ACP hydratase activity" EXACT []
synonym: "crotonoyl-acyl-carrier-protein hydratase activity" EXACT [EC:4.2.1.58]
synonym: "crotonyl acyl carrier protein hydratase activity" EXACT [EC:4.2.1.58]
synonym: "enoyl acyl carrier protein hydrase activity" EXACT [EC:4.2.1.58]
xref: EC:4.2.1.58
xref: KEGG:R04428
xref: MetaCyc:4.2.1.58-RXN
is_a: GO:0019171 ! 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity

[Term]
id: GO:0047451
name: 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3R)-3-hydroxyoctanoyl-[acyl-carrier protein] = H2O + 2-octenoyl-[acyl-carrier protein]." [EC:4.2.1.59, MetaCyc:4.2.1.59-RXN]
synonym: "(3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] hydro-lyase activity" EXACT [EC:4.2.1.59]
synonym: "(3R)-3-hydroxyoctanoyl-acyl-carrier-protein hydro-lyase (oct-2-enoyl-acyl-carrier protein-forming)" EXACT [EC:4.2.1.59]
synonym: "(3R)-3-hydroxyoctanoyl-acyl-carrier-protein hydro-lyase activity" EXACT [EC:4.2.1.59]
synonym: "3-hydroxyoctanoyl-[acyl-carrier protein] dehydratase activity" EXACT []
synonym: "3-hydroxyoctanoyl-ACP dehydratase activity" EXACT []
synonym: "3-hydroxyoctanoyl-acyl-carrier-protein dehydratase activity" EXACT [EC:4.2.1.59]
synonym: "beta-hydroxyoctanoyl thioester dehydratase activity" EXACT [EC:4.2.1.59]
synonym: "beta-hydroxyoctanoyl-ACP-dehydrase activity" EXACT [EC:4.2.1.59]
synonym: "beta-hydroxyoctanoyl-acyl carrier protein dehydrase activity" EXACT [EC:4.2.1.59]
synonym: "D-3-hydroxyoctanoyl-[acyl carrier protein] dehydratase activity" EXACT [EC:4.2.1.59]
synonym: "D-3-hydroxyoctanoyl-acyl carrier protein dehydratase activity" EXACT [EC:4.2.1.59]
xref: EC:4.2.1.59
xref: KEGG:R04537
xref: MetaCyc:4.2.1.59-RXN
is_a: GO:0019171 ! 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity

[Term]
id: GO:0047452
name: protoaphin-aglucone dehydratase (cyclizing) activity
namespace: molecular_function
def: "Catalysis of the reaction: protoaphin aglucone = H(2)O + xanthoaphin." [EC:4.2.1.73, RHEA:23879]
synonym: "protoaphin dehydratase (cyclizing)" EXACT [EC:4.2.1.73]
synonym: "protoaphin dehydratase activity" EXACT [EC:4.2.1.73]
synonym: "protoaphin-aglucone hydro-lyase (cyclizing)" EXACT [EC:4.2.1.73]
synonym: "protoaphin-aglucone hydro-lyase (cyclizing; xanthoaphin-forming)" EXACT [EC:4.2.1.73]
xref: EC:4.2.1.73
xref: KEGG:R03742
xref: MetaCyc:4.2.1.73-RXN
xref: RHEA:23879
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047453
name: ATP-dependent NAD(P)H-hydrate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine dinucleotide + ATP = ADP + 3 H(+) + NADH + phosphate." [EC:4.2.1.93, RHEA:19020]
synonym: "(6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ATP-hydrolysing)" EXACT [EC:4.2.1.93]
synonym: "(6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase(ATP-hydrolysing; NADH-forming)" RELATED [EC:4.2.1.93]
synonym: "ATP-dependent H(4)NAD(P)OH dehydratase activity" EXACT []
synonym: "ATP-dependent H4NAD(P)OH dehydratase activity" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide hydrate dehydratase activity" BROAD [EC:4.2.1.93]
xref: EC:4.2.1.93
xref: KEGG:R00129
xref: MetaCyc:4.2.1.93-RXN
xref: RHEA:19020
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047454
name: phaseollidin hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: phaseollidin hydrate = H(2)O + phaseollidin." [EC:4.2.1.97, RHEA:19772]
synonym: "phaseollidin-hydrate hydro-lyase (phaseollidin-forming)" EXACT [EC:4.2.1.97]
synonym: "phaseollidin-hydrate hydro-lyase activity" EXACT [EC:4.2.1.97]
xref: EC:4.2.1.97
xref: KEGG:R04728
xref: MetaCyc:4.2.1.97-RXN
xref: RHEA:19772
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047455
name: 16-alpha-hydroxyprogesterone dehydratase activity
namespace: molecular_function
alt_id: GO:0047523
def: "Catalysis of the reaction: 16-alpha-hydroxyprogesterone = H2O + 16-dehydroprogesterone." [EC:4.2.1.98, MetaCyc:4.2.1.98-RXN]
synonym: "16-alpha-dehydroxylase activity" EXACT [EC:4.2.1.98]
synonym: "16-alpha-hydroxyprogesterone dehydroxylase activity" EXACT [EC:4.2.1.98]
synonym: "16-dehydroprogesterone hydratase activity" RELATED []
synonym: "16alpha-dehydroxylase activity" EXACT [EC:4.2.1.98]
synonym: "16alpha-hydroxyprogesterone dehydratase activity" EXACT [EC:4.2.1.98]
synonym: "16alpha-hydroxyprogesterone dehydroxylase activity" EXACT [EC:4.2.1.98]
synonym: "16alpha-hydroxyprogesterone hydro-lyase (16,17-didehydroprogesterone-forming)" EXACT [EC:4.2.1.98]
synonym: "16alpha-hydroxyprogesterone hydro-lyase activity" EXACT [EC:4.2.1.98]
synonym: "hydroxyprogesterone dehydroxylase activity" EXACT []
xref: EC:4.2.1.98
xref: MetaCyc:4.2.1.98-RXN
xref: RHEA:12587
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047456
name: 2-methylisocitrate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = cis-2-methylaconitate + H(2)O." [EC:4.2.1.99, RHEA:17944]
subset: gosubset_prok
synonym: "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate hydro-lyase [(Z)-but-2-ene-1,2,3-tricarboxylate-forming]" RELATED [EC:4.2.1.99]
synonym: "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate hydro-lyase activity" EXACT [EC:4.2.1.99]
xref: EC:4.2.1.99
xref: KEGG:R04425
xref: MetaCyc:4.2.1.99-RXN
xref: RHEA:17944
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047457
name: exo-(1,4)-alpha-D-glucan lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: linear alpha-D-glucan = 1,5-anhydro-D-fructose + beta-D-glucose." [EC:4.2.2.13, MetaCyc:4.2.2.13-RXN]
synonym: "(1->4)-alpha-D-glucan exo-4-lyase (1,5-anhydro-D-fructose-forming)" EXACT [EC:4.2.2.13]
synonym: "alpha-(1->4)-glucan 1,5-anhydro-D-fructose eliminase activity" EXACT [EC:4.2.2.13]
synonym: "alpha-1,4-glucan 1,5-anhydro-D-fructose eliminase activity" EXACT [EC:4.2.2.13]
synonym: "alpha-1,4-glucan exo-lyase activity" EXACT [EC:4.2.2.13]
synonym: "alpha-1,4-glucan lyase activity" BROAD [EC:4.2.2.13]
synonym: "exo-(1->4)-alpha-D-glucan lyase activity" EXACT [EC:4.2.2.13]
synonym: "exo-alpha-1,4-glucan lyase activity" EXACT [EC:4.2.2.13]
xref: EC:4.2.2.13
xref: MetaCyc:4.2.2.13-RXN
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0047458
name: beta-pyrazolylalanine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: O-acetyl-L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + acetate + H(+)." [EC:2.5.1.51, RHEA:13120]
synonym: "3-O-acetyl-L-serine:pyrazole 1-(2-amino-2-carboxyethyl)transferase activity" EXACT [EC:2.5.1.51]
synonym: "beta-(1-pyrazolyl)alanine synthase activity" EXACT [EC:2.5.1.51]
synonym: "beta-pyrazolealanine synthase activity" EXACT [EC:2.5.1.51]
synonym: "beta-pyrazolylalanine synthase (acetylserine) activity" EXACT []
synonym: "BPA-synthase activity" EXACT [EC:2.5.1.51]
synonym: "O(3)-acetyl-L-serine acetate-lyase (adding pyrazole) activity" EXACT [EC:2.5.1.51]
synonym: "O3-acetyl-L-serine acetate-lyase (adding pyrazole)" EXACT [EC:2.5.1.51]
synonym: "O3-acetyl-L-serine:pyrazole 1-(2-amino-2-carboxyethyl)transferase activity" EXACT [EC:2.5.1.51]
synonym: "pyrazolealanine synthase activity" EXACT [EC:2.5.1.51]
synonym: "pyrazolylalaninase activity" EXACT [EC:2.5.1.51]
xref: EC:2.5.1.51
xref: KEGG:R03134
xref: MetaCyc:2.5.1.51-RXN
xref: RHEA:13120
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0047459
name: 3-aminobutyryl-CoA ammonia-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-3-aminobutanoyl-CoA = crotonoyl-CoA + NH(4)(+)." [EC:4.3.1.14, RHEA:10059]
synonym: "L-3-aminobutyryl-CoA ammonia-lyase (crotonoyl-CoA-forming)" EXACT [EC:4.3.1.14]
synonym: "L-3-aminobutyryl-CoA ammonia-lyase activity" EXACT [EC:4.3.1.14]
synonym: "L-3-aminobutyryl-CoA deaminase activity" EXACT [EC:4.3.1.14]
xref: EC:4.3.1.14
xref: KEGG:R03030
xref: MetaCyc:4.3.1.14-RXN
xref: RHEA:10059
is_a: GO:0016841 ! ammonia-lyase activity

[Term]
id: GO:0047460
name: L-2-amino-4-chloropent-4-enoate dehydrochlorinase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-2-amino-4-chloropent-4-enoate + H(2)O = 2-oxopent-4-enoate + chloride + H(+) + NH(4)(+)." [EC:4.5.1.4, RHEA:11623]
synonym: "L-2-amino-4-chloro-4-pentenoate dehalogenase activity" EXACT [EC:4.5.1.4]
synonym: "L-2-amino-4-chloropent-4-enoate chloride-lyase (adding H2O; deaminating; 2-oxopent-4-enoate-forming)" EXACT [EC:4.5.1.4]
synonym: "L-2-amino-4-chloropent-4-enoate chloride-lyase (deaminating)" EXACT [EC:4.5.1.4]
xref: EC:4.5.1.4
xref: KEGG:R02605
xref: MetaCyc:4.5.1.4-RXN
xref: RHEA:11623
is_a: GO:0016848 ! carbon-halide lyase activity

[Term]
id: GO:0047461
name: (+)-delta-cadinene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + (+)-delta-cadinene." [EC:4.2.3.13, MetaCyc:4.6.1.11-RXN]
synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, (+)-delta-cadinene-forming)" EXACT [EC:4.2.3.13]
synonym: "D-cadinene synthase activity" EXACT [EC:4.2.3.13]
xref: EC:4.2.3.13
xref: MetaCyc:4.6.1.11-RXN
xref: RHEA:19528
is_a: GO:0010334 ! sesquiterpene synthase activity

[Term]
id: GO:0047462
name: phenylalanine racemase (ATP-hydrolyzing) activity
namespace: molecular_function
def: "Catalysis of the reaction: L-phenylalanine + ATP + H(2)O = D-phenylalanine + AMP + diphosphate + 2 H(+)." [EC:5.1.1.11, RHEA:20204]
subset: gosubset_prok
synonym: "gramicidin S synthetase I" RELATED [EC:5.1.1.11]
synonym: "phenylalanine racemase (adenosine triphosphate-hydrolysing)" EXACT [EC:5.1.1.11]
synonym: "phenylalanine racemase (ATP-hydrolysing)" BROAD [EC:5.1.1.11]
synonym: "phenylalanine racemase activity" EXACT [EC:5.1.1.11]
xref: EC:5.1.1.11
xref: KEGG:R00686
xref: MetaCyc:5.1.1.11-RXN
xref: RHEA:20204
is_a: GO:0047661 ! amino-acid racemase activity

[Term]
id: GO:0047463
name: 2-aminohexano-6-lactam racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-2-aminohexano-6-lactam = D-2-aminohexano-6-lactam." [EC:5.1.1.15, RHEA:14816]
synonym: "2-amino-hexano-6-lactam racemase activity" EXACT [EC:5.1.1.15]
synonym: "alpha-amino-epsilon-caprolactam racemase activity" EXACT [EC:5.1.1.15]
xref: EC:5.1.1.15
xref: KEGG:R04736
xref: MetaCyc:5.1.1.15-RXN
xref: RHEA:14816
is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives

[Term]
id: GO:0047464
name: heparosan-N-sulfate-glucuronate 5-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: heparosan-N-sulfate D-glucuronate = heparosan-N-sulfate L-iduronate." [EC:5.1.3.17, MetaCyc:5.1.3.17-RXN]
synonym: "C-5 uronosyl epimerase activity" EXACT [EC:5.1.3.17]
synonym: "D-glucuronyl C-5 epimerase activity" EXACT [EC:5.1.3.17]
synonym: "heparosan epimerase activity" EXACT [EC:5.1.3.17]
synonym: "heparosan-N-sulfate-D-glucuronosyl 5-epimerase activity" EXACT [EC:5.1.3.17]
synonym: "heparosan-N-sulphate-glucuronate 5-epimerase activity" EXACT []
synonym: "poly[(1,4)-beta-D-glucuronosyl-(1,4)-N-sulfo-alpha-D-glucosaminyl] glucurono-5-epimerase activity" EXACT [EC:5.1.3.17]
synonym: "polyglucuronate epimerase activity" EXACT [EC:5.1.3.17]
xref: EC:5.1.3.17
xref: MetaCyc:5.1.3.17-RXN
xref: RHEA:20200
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0047465
name: N-acylglucosamine-6-phosphate 2-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acyl-D-glucosamine 6-phosphate = N-acyl-D-mannosamine 6-phosphate." [EC:5.1.3.9, MetaCyc:5.1.3.9-RXN]
subset: gosubset_prok
synonym: "acylglucosamine phosphate 2-epimerase activity" EXACT [EC:5.1.3.9]
synonym: "acylglucosamine-6-phosphate 2-epimerase activity" EXACT [EC:5.1.3.9]
synonym: "acylmannosamine phosphate 2-epimerase activity" EXACT [EC:5.1.3.9]
synonym: "N-acetylglucosmamine 6-phosphate 2-epimerase activity" EXACT [EC:5.1.3.9]
synonym: "N-acetylmannosamine-6-phosphate 2-epimerase activity" EXACT [EC:5.1.3.9]
synonym: "N-acyl-D-glucosamine-6-phosphate 2-epimerase activity" EXACT [EC:5.1.3.9]
xref: EC:5.1.3.9
xref: MetaCyc:5.1.3.9-RXN
xref: RHEA:23935
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0047466
name: 2-chloro-4-carboxymethylenebut-2-en-1,4-olide isomerase activity
namespace: molecular_function
alt_id: GO:0018840
def: "Catalysis of the reaction: cis-2-chloro-4-carboxymethylenebut-2-en-1,4-olide = trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide." [EC:5.2.1.10, RHEA:10927]
synonym: "2-chloro-4-carboxymethylenebut-2-en-1,4-olide cis-trans-isomerase activity" EXACT [EC:5.2.1.10]
synonym: "2-chlorocarboxymethylenebutenolide isomerase activity" EXACT [EC:5.2.1.-]
synonym: "chlorodienelactone isomerase activity" EXACT [EC:5.2.1.-]
xref: EC:5.2.1.10
xref: KEGG:R04576
xref: MetaCyc:5.2.1.10-RXN
xref: RHEA:10927
xref: UM-BBD_reactionID:r0278
is_a: GO:0016859 ! cis-trans isomerase activity

[Term]
id: GO:0047467
name: 4-hydroxyphenylacetaldehyde-oxime isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: (E)-4-hydroxyphenylacetaldehyde oxime = (Z)-4-hydroxyphenylacetaldehyde oxime." [EC:5.2.1.11, MetaCyc:5.2.1.11-RXN]
is_a: GO:0016859 ! cis-trans isomerase activity

[Term]
id: GO:0047468
name: phosphoglucomutase (glucose-cofactor) activity
namespace: molecular_function
def: "Catalysis of the reaction: glucose-1-phosphate = glucose-6-phosphate; using D-glucose as a cofactor." [EC:5.4.2.5, MetaCyc:5.4.2.5-RXN]
synonym: "alpha-D-glucose 1,6-phosphomutase (glucose-cofactor)" EXACT [EC:5.4.2.5]
synonym: "glucose-1-phosphate phosphotransferase activity" EXACT [EC:5.4.2.5]
xref: EC:5.4.2.5
xref: MetaCyc:5.4.2.5-RXN
is_a: GO:0004614 ! phosphoglucomutase activity

[Term]
id: GO:0047469
name: 4-carboxymethyl-4-methylbutenolide mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-carboxymethyl-4-methylbut-2-en-1,4-olide = 4-carboxymethyl-3-methylbut-2-en-1,4-olide." [EC:5.4.99.14, RHEA:19240]
synonym: "4-carboxymethyl-4-methylbut-2-en-1,4-olide methylmutase activity" EXACT [EC:5.4.99.14]
synonym: "4-methyl-2-enelactone isomerase activity" EXACT [EC:5.4.99.14]
synonym: "4-methyl-2-enelactone methyl-isomerase activity" EXACT [EC:5.4.99.14]
synonym: "4-methyl-3-enelactone methyl isomerase activity" EXACT [EC:5.4.99.14]
synonym: "4-methylmuconolactone methylisomerase activity" EXACT [EC:5.4.99.14]
xref: EC:5.4.99.14
xref: KEGG:R04510
xref: MetaCyc:5.4.99.14-RXN
xref: RHEA:19240
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0047470
name: (1,4)-alpha-D-glucan 1-alpha-D-glucosylmutase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-[(1->4)-alpha-D-glucosyl](n-1)-D-glucose = 1-alpha-D-[(1->4)-alpha-D-glucosyl](n-1)-alpha-D-glucopyranoside." [EC:5.4.99.15, MetaCyc:5.4.99.15-RXN]
subset: gosubset_prok
synonym: "(1->4)-alpha-D-glucan 1-alpha-D-glucosylmutase" BROAD [EC:5.4.99.15]
synonym: "malto-oligosyltrehalose synthase activity" EXACT [EC:5.4.99.15]
synonym: "maltodextrin alpha-D-glucosyltransferase activity" EXACT [EC:5.4.99.15]
xref: EC:5.4.99.15
xref: MetaCyc:5.4.99.15-RXN
xref: Reactome:REACT_27294 "1,4-alpha-glucan is converted to glucanotrehalose, Mycobacterium tuberculosis"
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0047471
name: maltose alpha-D-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: maltose = trehalose." [EC:5.4.99.16, MetaCyc:5.4.99.16-RXN]
subset: gosubset_prok
synonym: "maltose alpha-D-glucosylmutase activity" EXACT [EC:5.4.99.16]
synonym: "maltose glucosylmutase activity" EXACT [EC:5.4.99.16]
synonym: "trehalose synthase activity" EXACT [EC:5.4.99.16]
xref: EC:5.4.99.16
xref: MetaCyc:5.4.99.16-RXN
xref: Reactome:REACT_27236 "Maltose is converted to trehalose, Mycobacterium tuberculosis"
xref: RHEA:15148
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0047472
name: 3-carboxy-cis,cis-muconate cycloisomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate = 3-carboxy-cis,cis-muconate + H(+)." [EC:5.5.1.2, RHEA:23659]
subset: gosubset_prok
synonym: "2-carboxy-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)" EXACT [EC:5.5.1.2]
synonym: "3-carboxymuconate lactonizing enzyme activity" EXACT [EC:5.5.1.2]
synonym: "3-carboxymuconolactone hydrolase activity" EXACT [EC:5.5.1.2]
synonym: "beta-carboxymuconate lactonizing enzyme activity" EXACT [EC:5.5.1.2]
synonym: "CMLE activity" EXACT [EC:5.5.1.2]
xref: EC:5.5.1.2
xref: KEGG:R03307
xref: MetaCyc:5.5.1.2-RXN
xref: RHEA:23659
is_a: GO:0016872 ! intramolecular lyase activity

[Term]
id: GO:0047473
name: D-alanine-poly(phosphoribitol) ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: poly(ribitol phosphate) + D-alanine + ATP = O-D-alanyl-poly(ribitol phosphate) + diphosphate + AMP." [EC:6.1.1.13, MetaCyc:6.1.1.13-RXN]
subset: gosubset_prok
synonym: "D-alanine-activating enzyme activity" RELATED [EC:6.1.1.13]
synonym: "D-alanine-D-alanyl carrier protein ligase activity" EXACT [EC:6.1.1.13]
synonym: "D-alanine-membrane acceptor ligase activity" EXACT [EC:6.1.1.13]
synonym: "D-alanine: membrane acceptor ligase activity" EXACT [EC:6.1.1.13]
synonym: "D-alanine:poly(phosphoribitol) ligase (AMP-forming)" EXACT [EC:6.1.1.13]
synonym: "D-alanyl-poly(phosphoribitol) synthetase activity" EXACT [EC:6.1.1.13]
xref: EC:6.1.1.13
xref: MetaCyc:6.1.1.13-RXN
is_a: GO:0016876 ! ligase activity, forming aminoacyl-tRNA and related compounds

[Term]
id: GO:0047474
name: long-chain fatty acid luciferin component ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein + an acid + ATP = an acyl-protein thiolester + diphosphate + AMP. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [CHEBI:15904, EC:6.2.1.19, MetaCyc:6.2.1.19-RXN]
subset: gosubset_prok
synonym: "acyl-protein synthetase activity" RELATED [EC:6.2.1.19]
synonym: "long-chain-fatty-acid luciferin component ligase activity" EXACT [GOC:mah]
synonym: "long-chain-fatty-acid-luciferin-component ligase activity" EXACT []
synonym: "long-chain-fatty-acid:protein ligase (AMP-forming)" EXACT [EC:6.2.1.19]
xref: EC:6.2.1.19
xref: MetaCyc:6.2.1.19-RXN
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0047475
name: phenylacetate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + CoA + phenylacetate = AMP + diphosphate + H(+) + phenylacetyl-CoA." [EC:6.2.1.30, RHEA:20959]
subset: gosubset_prok
synonym: "PA-CoA ligase activity" EXACT [EC:6.2.1.30]
synonym: "phenacyl coenzyme A synthetase activity" EXACT [EC:6.2.1.30]
synonym: "phenylacetate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.30]
synonym: "phenylacetyl-CoA ligase (AMP-forming)" EXACT [EC:6.2.1.30]
synonym: "phenylacetyl-CoA ligase activity" EXACT [EC:6.2.1.30]
xref: EC:6.2.1.30
xref: KEGG:R02539
xref: MetaCyc:PHENYLACETATE--COA-LIGASE-RXN
xref: RHEA:20959
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0047476
name: 3-alpha,7-alpha-dihydroxy-5-beta-cholestanate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: CoA + 3-alpha,7-alpha-dihydroxy-5-beta-cholestanate + ATP = 3-alpha,7-alpha-dihydroxy-5-beta-cholestanoyl-CoA + diphosphate + AMP." [EC:6.2.1.28, MetaCyc:6.2.1.28-RXN]
synonym: "3alpha,7alpha-dihydroxy-5beta-cholestanate-CoA ligase activity" EXACT [EC:6.2.1.28]
synonym: "3alpha,7alpha-dihydroxy-5beta-cholestanate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.28]
synonym: "3alpha,7alpha-dihydroxy-5beta-cholestanoyl coenzyme A synthetase activity" EXACT [EC:6.2.1.28]
synonym: "DHCA-CoA ligase activity" EXACT [EC:6.2.1.28]
xref: EC:6.2.1.28
xref: MetaCyc:6.2.1.28-RXN
xref: RHEA:21779
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0047478
name: aspartate-ammonia ligase (ADP-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: L-aspartate + ATP + NH(4)(+) = L-asparagine + ADP + 2 H(+) + phosphate." [EC:6.3.1.4, RHEA:14200]
synonym: "asparagine synthetase (adenosine diphosphate-forming)" EXACT [EC:6.3.1.4]
synonym: "asparagine synthetase (ADP-forming) activity" EXACT [EC:6.3.1.4]
synonym: "L-aspartate:ammonia ligase (ADP-forming)" EXACT [EC:6.3.1.4]
xref: EC:6.3.1.4
xref: KEGG:R00482
xref: MetaCyc:6.3.1.4-RXN
xref: RHEA:14200
is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity

[Term]
id: GO:0047479
name: trypanothione synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: reduced glutathione + glutathionylspermidine + ATP = trypanothione + ADP + phosphate." [EC:6.3.1.9, MetaCyc:6.3.1.9-RXN]
synonym: "glutathionylspermidine:glutathione ligase (ADP-forming)" EXACT [EC:6.3.1.9]
synonym: "TSR synthetase activity" EXACT [EC:6.3.1.9]
xref: EC:6.3.1.9
xref: MetaCyc:6.3.1.9-RXN
xref: RHEA:21535
is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity

[Term]
id: GO:0047480
name: UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine + ATP + D-alanyl-D-alanine = phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + ADP." [EC:6.3.2.10, MetaCyc:6.3.2.10-RXN]
comment: Note that the enzyme UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase also has UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity (GO:0008766).
subset: gosubset_prok
synonym: "MurF synthetase activity" RELATED [EC:6.3.2.10]
synonym: "UDP-MurNAc-L-Ala-D-Glu-L-Lys:D-Ala-D-Ala ligase activity" EXACT [EC:6.3.2.10]
synonym: "UDP-MurNAc-pentapeptide synthetase activity" EXACT [EC:6.3.2.10]
synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine:D-alanyl-D-alanine ligase (ADP-forming)" EXACT [EC:6.3.2.10]
synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine synthetase activity" EXACT [EC:6.3.2.10]
synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine synthetase activity" EXACT [EC:6.3.2.10]
synonym: "UDP-N-acetylmuramoylalanine-D-glutamyl-lysine--D-alanyl-D-alanine ligase activity" EXACT [EC:6.3.2.10]
synonym: "UDP-N-acetylmuramoylalanine-D-glutamyl-lysine-D-alanyl-D-alanine ligase activity" EXACT []
synonym: "UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase activity" EXACT [EC:6.3.2.10]
synonym: "UDP-N-acetylmuramoylalanyl-D-glutamyl-lysine-D-alanyl-D-alanine ligase activity" EXACT [EC:6.3.2.10]
synonym: "UDP-N-acetylmuramoylalanyl-tripeptide-D-alanyl-D-alanine ligase activity" EXACT []
synonym: "UDPacetylmuramoylpentapeptide synthetase activity" EXACT [EC:6.3.2.10]
synonym: "uridine diphosphoacetylmuramoylpentapeptide synthetase activity" EXACT [EC:6.3.2.10]
xref: EC:6.3.2.10
xref: MetaCyc:6.3.2.10-RXN
xref: RHEA:16088
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0047481
name: D-alanine-alanyl-poly(glycerolphosphate) ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: alanyl-poly(glycerolphosphate) + D-alanine + ATP = D-alanyl-alanyl-poly(glycerolphosphate) + phosphate + ADP." [EC:6.3.2.16, MetaCyc:6.3.2.16-RXN]
synonym: "D-alanine-membrane acceptor-ligase activity" EXACT [EC:6.3.2.16]
synonym: "D-alanine:alanyl-poly(glycerolphosphate) ligase (ADP-forming)" EXACT [EC:6.3.2.16]
synonym: "D-alanine:membrane-acceptor ligase activity" EXACT [EC:6.3.2.16]
synonym: "D-alanyl-alanyl-poly(glycerolphosphate) synthetase activity" EXACT [EC:6.3.2.16]
synonym: "D-alanyl-poly(phosphoglycerol) synthetase activity" EXACT [EC:6.3.2.16]
synonym: "D-alanylalanylpoly(phosphoglycerol) synthetase activity" EXACT [EC:6.3.2.16]
xref: EC:6.3.2.16
xref: MetaCyc:6.3.2.16-RXN
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0047482
name: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-lysine + ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate = ADP + 2 H(+) + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine." [EC:6.3.2.7, RHEA:17972]
subset: gosubset_prok
synonym: "L-lysine-adding enzyme activity" RELATED [EC:6.3.2.7]
synonym: "MurE synthetase activity" RELATED [EC:6.3.2.7]
synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:L-lysine gamma-ligase (ADP-forming)" EXACT [EC:6.3.2.7]
synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine synthetase activity" EXACT [EC:6.3.2.7]
synonym: "UPD-MurNAc-L-Ala-D-Glu:L-Lys ligase activity" EXACT [EC:6.3.2.7]
synonym: "uridine diphospho-N-acetylmuramoylalanyl-D-glutamyllysine synthetase activity" EXACT [EC:6.3.2.7]
xref: EC:6.3.2.7
xref: KEGG:R02786
xref: MetaCyc:6.3.2.7-RXN
xref: RHEA:17972
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0047483
name: imidazoleacetate-phosphoribosyldiphosphate ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H(2)O + imidazol-4-ylacetate = 1-(5-phosphoribosyl)imidazol-4-ylacetate + ADP + diphosphate + 2 H(+) + phosphate." [EC:6.3.4.8, RHEA:16488]
synonym: "5-phosphoribosylimidazoleacetate synthetase activity" EXACT [EC:6.3.4.8]
synonym: "imidazoleacetate:5-phosphoribosyl-diphosphate ligase (ADP- and diphosphate-forming)" EXACT [EC:6.3.4.8]
xref: EC:6.3.4.8
xref: KEGG:R04068
xref: MetaCyc:6.3.4.8-RXN
xref: RHEA:16488
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0047484
name: regulation of response to osmotic stress
namespace: biological_process
def: "Any process that modulates the rate or extent of the response to osmotic stress." [GOC:ai]
is_a: GO:0080134 ! regulation of response to stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006970 ! response to osmotic stress
relationship: regulates GO:0006970 ! response to osmotic stress

[Term]
id: GO:0047485
name: protein N-terminus binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue." [ISBN:0198506732]
synonym: "amino-terminal binding" RELATED [GOC:jsg]
synonym: "amino-terminus binding" RELATED [GOC:jsg]
synonym: "N-terminal binding" EXACT []
synonym: "N-terminal end binding" EXACT [GOC:jsg]
synonym: "NH2-terminal binding" NARROW [GOC:jsg]
synonym: "NH2-terminus binding" NARROW [GOC:jsg]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0047486
name: chondroitin ABC lyase activity
namespace: molecular_function
def: "Catalysis of the eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl or 1,3-alpha-L-iduronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups." [EC:4.2.2.4]
comment: This term represents a deleted EC activity and is scheduled for obsoletion.
subset: mf_needs_review
xref: EC:4.2.2.4
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0047487
name: oligogalacturonide lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-(4-deoxy-alpha-D-gluc-4-enuronosyl)-D-galacturonate = 2 5-dehydro-4-deoxy-D-glucuronate." [EC:4.2.2.6, MetaCyc:OLIGOGALACTURONIDE-LYASE-RXN]
subset: gosubset_prok
synonym: "OGTE" RELATED [EC:4.2.2.6]
synonym: "oligogalacturonate lyase activity" EXACT [EC:4.2.2.6]
synonym: "unsaturated oligogalacturonate transeliminase activity" EXACT [EC:4.2.2.6]
xref: EC:4.2.2.6
xref: MetaCyc:OLIGOGALACTURONIDE-LYASE-RXN
xref: RHEA:20272
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0047488
name: heparin lyase activity
namespace: molecular_function
def: "Catalysis of the eliminative cleavage of polysaccharides containing 1,4-linked D-glucuronate or L-iduronate residues and 1,4-alpha-linked 2-sulfoamino-2-deoxy-6-sulfo-D-glucose residues to give oligosaccharides with terminal 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their nonreducing ends." [EC:4.2.2.7, MetaCyc:4.2.2.7-RXN]
subset: gosubset_prok
synonym: "heparan sulfate lyase activity" RELATED []
synonym: "heparin eliminase activity" RELATED [EC:4.2.2.7]
synonym: "heparinase activity" EXACT [EC:4.2.2.7]
xref: EC:4.2.2.7
xref: MetaCyc:4.2.2.7-RXN
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0047489
name: pectate disaccharide-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: a pectate = a pectate + 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate. This reaction is the eliminative cleavage of 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate from the reducing end of pectate, i.e. de-esterified pectin." [EC:4.2.2.9]
subset: gosubset_prok
synonym: "(1->4)-alpha-D-galacturonan reducing-end-disaccharide-lyase activity" EXACT [EC:4.2.2.9]
synonym: "exo-PATE" RELATED [EC:4.2.2.9]
synonym: "Exo-PATE activity" EXACT [EC:4.2.2.9]
synonym: "exo-PGL" RELATED [EC:4.2.2.9]
synonym: "Exo-PGL activity" EXACT [EC:4.2.2.9]
synonym: "exopectate lyase activity" EXACT [EC:4.2.2.9]
synonym: "exopectic acid transeliminase activity" EXACT [EC:4.2.2.9]
synonym: "exopolygalacturonate lyase activity" EXACT [EC:4.2.2.9]
synonym: "exopolygalacturonic acid-trans-eliminase activity" EXACT [EC:4.2.2.9]
synonym: "PATE activity" EXACT [EC:4.2.2.9]
synonym: "pectate exo-lyase activity" EXACT [EC:4.2.2.9]
xref: EC:4.2.2.9
xref: MetaCyc:4.2.2.9-RXN
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0047490
name: pectin lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: a pectin = an oligosaccharide with 4-deoxy-6-O-methyl-alpha-D-galact-4-enuronate end + a pectin. This reaction is the eliminative cleavage of (1->4)-alpha-D-galacturonan methyl ester to give oligosaccharides with 4-deoxy-6-O-methyl-alpha-D-galact-4-enuronosyl groups at their nonreducing ends." [EC:4.2.2.10]
subset: gosubset_prok
synonym: "(1->4)-6-O-methyl-alpha-D-galacturonan lyase activity" EXACT [EC:4.2.2.10]
synonym: "endo-pectin lyase activity" EXACT [EC:4.2.2.10]
synonym: "pectin methyltranseliminase activity" EXACT [EC:4.2.2.10]
synonym: "pectin trans-eliminase activity" BROAD [EC:4.2.2.10]
synonym: "pectolyase activity" EXACT [EC:4.2.2.10]
synonym: "PL activity" EXACT [EC:4.2.2.10]
synonym: "PMGL activity" EXACT [EC:4.2.2.10]
synonym: "PNL activity" EXACT [EC:4.2.2.10]
synonym: "polymethylgalacturonic transeliminase activity" EXACT [EC:4.2.2.10]
xref: EC:4.2.2.10
xref: MetaCyc:4.2.2.10-RXN
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0047491
name: poly(alpha-L-guluronate) lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: polysaccharides containing a terminal alpha-L-guluronate group = oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enuronosyl end. This reaction is the eliminative cleavage of polysaccharides containing a terminal a-L-guluronate group, to give oligopolysaccharides with 4-deoxy-a-L-erythro-hex-4-enuronosyl groups at their nonreducing ends." [EC:4.2.2.11]
subset: gosubset_prok
synonym: "alginase II activity" RELATED [EC:4.2.2.11]
synonym: "guluronate lyase activity" EXACT [EC:4.2.2.11]
synonym: "L-guluronan lyase activity" EXACT [EC:4.2.2.11]
synonym: "L-guluronate lyase activity" EXACT [EC:4.2.2.11]
synonym: "poly(alpha-L-1,4-guluronide) exo-lyase activity" EXACT [EC:4.2.2.11]
synonym: "poly-alpha-L-guluronate lyase activity" EXACT [EC:4.2.2.11]
synonym: "polyguluronate-specific alginate lyase activity" EXACT [EC:4.2.2.11]
xref: EC:4.2.2.11
xref: MetaCyc:4.2.2.11-RXN
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0047492
name: xanthan lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: xanthan = oligosaccharide with 4-deoxy-alpha-L-threo-hex-4-enuronosyl end + pyruvylate mannose. This reaction is the eliminative cleavage of the terminal beta-D-mannosyl-beta-D-1,4-glucuronosyl linkage of the side-chain of the polysaccharide xanthan, leaving a 4-deoxy-alpha-L-threo-hex-4-enuronosyl group at the terminus of the side-chain." [EC:4.2.2.12]
xref: EC:4.2.2.12
xref: MetaCyc:4.2.2.12-RXN
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0047493
name: ceramide cholinephosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CDP-choline + ceramide = CMP + H(+) + sphingomyelin." [EC:2.7.8.3, RHEA:16276]
subset: gosubset_prok
synonym: "CDP-choline:N-acylsphingosine cholinephosphotransferase activity" EXACT [EC:2.7.8.3]
synonym: "phosphorylcholine-ceramide transferase activity" EXACT [EC:2.7.8.3]
xref: EC:2.7.8.3
xref: KEGG:R01891
xref: MetaCyc:CERAMIDE-CHOLINEPHOSPHOTRANSFERASE-RXN
xref: RHEA:16276
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0047494
name: serine-phosphoethanolamine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-serine + CDP-ethanolamine = L-serine-phosphoethanolamine + CMP + H(+)." [EC:2.7.8.4, RHEA:22659]
synonym: "CDP-ethanolamine:L-serine ethanolamine phosphotransferase activity" EXACT [EC:2.7.8.4]
synonym: "serine ethanolamine phosphate synthetase activity" EXACT [EC:2.7.8.4]
synonym: "serine ethanolamine phosphodiester synthase activity" EXACT [EC:2.7.8.4]
synonym: "serine ethanolaminephosphotransferase activity" EXACT [EC:2.7.8.4]
synonym: "serine-phosphinico-ethanolamine synthase activity" EXACT [EC:2.7.8.4]
synonym: "serinephosphoethanolamine synthase activity" EXACT [EC:2.7.8.4]
xref: EC:2.7.8.4
xref: KEGG:R02563
xref: MetaCyc:SERINE-PHOSPHOETHANOLAMINE-SYNTHASE-RXN
xref: RHEA:22659
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0047495
name: membrane-oligosaccharide glycerophosphotransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a glycerophospho group from one membrane-derived oligosaccharide to another." [EC:2.7.8.21]
synonym: "membrane-derived-oligosaccharide-6-(glycerophospho)-D-glucose:membrane-derived-oligosaccharide-D-glucose glycerophosphotransferase activity" EXACT [EC:2.7.8.21]
synonym: "periplasmic phosphoglycerotransferase activity" NARROW [EC:2.7.8.21]
synonym: "phosphoglycerol cyclase activity" RELATED [EC:2.7.8.21]
xref: EC:2.7.8.21
xref: MetaCyc:2.7.8.21-RXN
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0047496
name: vesicle transport along microtubule
namespace: biological_process
def: "The directed movement of a vesicle along a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination." [GOC:ecd, GOC:rl]
synonym: "microtubule-based vesicle localization" EXACT [GOC:rl]
is_a: GO:0072384 ! organelle transport along microtubule
is_a: GO:0099518 ! vesicle cytoskeletal trafficking

[Term]
id: GO:0047497
name: mitochondrion transport along microtubule
namespace: biological_process
def: "The directed movement of a mitochondrion along a microtubule, mediated by motor proteins." [GOC:ecd]
synonym: "mitochondrial migration along microtubule" EXACT []
synonym: "mitochondrial transport along microtubule" EXACT []
is_a: GO:0034643 ! establishment of mitochondrion localization, microtubule-mediated
is_a: GO:0072384 ! organelle transport along microtubule

[Term]
id: GO:0047498
name: calcium-dependent phospholipase A2 activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction requires Ca2+." [EC:3.1.1.4]
synonym: "calcium-dependent cytosolic phospholipase A2 activity" NARROW []
synonym: "calcium-dependent secreted phospholipase A2 activity" NARROW []
is_a: GO:0004623 ! phospholipase A2 activity

[Term]
id: GO:0047499
name: calcium-independent phospholipase A2 activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction does not require Ca2+." [EC:3.1.1.4]
subset: goslim_chembl
synonym: "calcium-independent cytosolic phospholipase A2 activity" NARROW []
is_a: GO:0004623 ! phospholipase A2 activity

[Term]
id: GO:0047500
name: (+)-borneol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (+)-borneol + NAD(+) = (1R, 4R)-camphor + H(+) + NADH." [EC:1.1.1.198, RHEA:17332]
synonym: "(+)-borneol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.198]
synonym: "bicyclic monoterpenol dehydrogenase activity" EXACT [EC:1.1.1.198]
xref: EC:1.1.1.198
xref: KEGG:R02944
xref: MetaCyc:+-BORNEOL-DEHYDROGENASE-RXN
xref: RHEA:17332
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047501
name: (+)-neomenthol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (+)-neomenthol + NADP(+) = (2S,5R)-menthone + H(+) + NADPH." [EC:1.1.1.208, RHEA:23815]
synonym: "(+)-neomenthol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.208]
synonym: "monoterpenoid dehydrogenase activity" BROAD [EC:1.1.1.208]
xref: EC:1.1.1.208
xref: KEGG:R02548
xref: MetaCyc:+-NEOMENTHOL-DEHYDROGENASE-RXN
xref: RHEA:23815
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047502
name: (+)-sabinol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (+)-cis-sabinol + NAD(+) = (1S,5S)-sabinone + H(+) + NADH." [EC:1.1.1.228, RHEA:18332]
synonym: "(+)-cis-sabinol dehydrogenase activity" EXACT [EC:1.1.1.228]
synonym: "(+)-cis-sabinol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.228]
xref: EC:1.1.1.228
xref: KEGG:R03745
xref: MetaCyc:+-SABINOL-DEHYDROGENASE-RXN
xref: RHEA:18332
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047503
name: (-)-borneol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (-)-borneol + NAD(+) = (1S,4S)-camphor + H(+) + NADH." [EC:1.1.1.227, RHEA:22131]
synonym: "(-)-borneol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.227]
xref: EC:1.1.1.227
xref: KEGG:R02945
xref: MetaCyc:--BORNEOL-DEHYDROGENASE-RXN
xref: RHEA:22131
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047504
name: (-)-menthol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (-)-menthol + NADP(+) = (2S,5R)-menthone + H(+) + NADPH." [EC:1.1.1.207, RHEA:13920]
synonym: "(-)-menthol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.207]
synonym: "monoterpenoid dehydrogenase activity" BROAD [EC:1.1.1.207]
xref: EC:1.1.1.207
xref: KEGG:R02177
xref: MetaCyc:--MENTHOL-DEHYDROGENASE-RXN
xref: RHEA:13920
xref: UM-BBD_reactionID:r1182
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047505
name: (-)-menthol monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (-)-menthol + H(+) + NADPH + O(2) = 1,4-menthane-3,8-diol + H(2)O + NADP(+)." [EC:1.14.13.46, RHEA:11651]
synonym: "(-)-menthol,NADPH:oxygen oxidoreductase (8-hydroxylating)" EXACT [EC:1.14.13.46]
synonym: "l-menthol monooxygenase activity" EXACT [EC:1.14.13.46]
xref: EC:1.14.13.46
xref: KEGG:R02178
xref: MetaCyc:--MENTHOL-MONOOXYGENASE-RXN
xref: RHEA:11651
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047506
name: (deoxy)adenylate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + dAMP = ADP + dADP." [EC:2.7.4.11, MetaCyc:DEOXYADENYLATE-KINASE-RXN]
synonym: "ATP:(d)AMP phosphotransferase activity" EXACT [EC:2.7.4.11]
xref: EC:2.7.4.11
xref: MetaCyc:DEOXYADENYLATE-KINASE-RXN
xref: RHEA:23103
is_a: GO:0016301 ! kinase activity
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor

[Term]
id: GO:0047507
name: (deoxy)nucleoside-phosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + deoxynucleoside phosphate = ADP + deoxynucleoside diphosphate." [EC:2.7.4.13, MetaCyc:DEOXYNUCLEOSIDE-PHOSPHATE-KINASE-RXN]
synonym: "ATP:deoxynucleoside-phosphate phosphotransferase activity" EXACT [EC:2.7.4.13]
synonym: "deoxynucleoside monophosphate kinase activity" EXACT [EC:2.7.4.13]
synonym: "deoxynucleoside-5'-monophosphate kinase activity" EXACT [EC:2.7.4.13]
synonym: "deoxyribonucleoside monophosphokinase activity" EXACT [EC:2.7.4.13]
xref: EC:2.7.4.13
xref: MetaCyc:DEOXYNUCLEOSIDE-PHOSPHATE-KINASE-RXN
xref: RHEA:11219
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor
is_a: GO:0019205 ! nucleobase-containing compound kinase activity

[Term]
id: GO:0047508
name: (R)-2-methylmalate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-citramalate = 2-methylmaleate + H(2)O." [EC:4.2.1.35, RHEA:22335]
synonym: "(-)-citramalate hydro-lyase activity" EXACT [EC:4.2.1.35]
synonym: "(R)-2-methylmalate hydro-lyase (2-methylmaleate-forming)" EXACT [EC:4.2.1.35]
synonym: "(R)-2-methylmalate hydro-lyase activity" EXACT [EC:4.2.1.35]
synonym: "citraconase activity" EXACT [EC:4.2.1.35]
synonym: "citraconate hydratase activity" EXACT [EC:4.2.1.35]
synonym: "citramalate hydro-lyase activity" EXACT [EC:4.2.1.35]
xref: EC:4.2.1.35
xref: KEGG:R03896
xref: MetaCyc:R-2-METHYLMALATE-DEHYDRATASE-RXN
xref: RHEA:22335
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047509
name: (R)-dehydropantoate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-4-dehydropantoate + H(2)O + NAD(+) = (R)-3,3-dimethylmalate + 2 H(+) + NADH." [EC:1.2.1.33, RHEA:19352]
synonym: "(R)-4-dehydropantoate:NAD+ 4-oxidoreductase activity" EXACT [EC:1.2.1.33]
synonym: "D-2-hydroxy-3,3-dimethyl-3-formylpropionate:diphosphopyridine nucleotide (DPN+) oxidoreductase activity" EXACT [EC:1.2.1.33]
synonym: "D-aldopantoate dehydrogenase activity" EXACT [EC:1.2.1.33]
xref: EC:1.2.1.33
xref: KEGG:R03198
xref: MetaCyc:R-DEHYDROPANTOATE-DEHYDROGENASE-RXN
xref: RHEA:19352
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047510
name: (S)-2-methylmalate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-citramalate = H(2)O + mesaconate." [EC:4.2.1.34, RHEA:13532]
synonym: "(+)-citramalate hydro-lyase activity" EXACT [EC:4.2.1.34]
synonym: "(+)-citramalic hydro-lyase activity" EXACT [EC:4.2.1.34]
synonym: "(S)-2-methylmalate hydro-lyase (2-methylfumarate-forming)" EXACT [EC:4.2.1.34]
synonym: "(S)-2-methylmalate hydro-lyase activity" EXACT [EC:4.2.1.34]
synonym: "citramalate dehydratase activity" EXACT [EC:4.2.1.34]
synonym: "L-citramalate hydrolase activity" EXACT [EC:4.2.1.34]
synonym: "mesaconase activity" EXACT [EC:4.2.1.34]
synonym: "mesaconate hydratase activity" EXACT [EC:4.2.1.34]
synonym: "mesaconate mesaconase activity" EXACT [EC:4.2.1.34]
xref: EC:4.2.1.34
xref: KEGG:R03693
xref: MetaCyc:S-2-METHYLMALATE-DEHYDRATASE-RXN
xref: RHEA:13532
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047511
name: (S)-methylmalonyl-CoA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-methylmalonyl-CoA + H(2)O = CoA + H(+) + methylmalonate." [EC:3.1.2.17, RHEA:17348]
synonym: "D-methylmalonyl-coenzyme A hydrolase activity" EXACT [EC:3.1.2.17]
xref: EC:3.1.2.17
xref: KEGG:R02764
xref: MetaCyc:S-METHYLMALONYL-COA-HYDROLASE-RXN
xref: RHEA:17348
is_a: GO:0016289 ! CoA hydrolase activity

[Term]
id: GO:0047512
name: (S,S)-butanediol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S,S)-butane-2,3-diol + NAD(+) = acetoin + H(+) + NADH." [EC:1.1.1.76, RHEA:12187]
synonym: "(S,S)-butane-2,3-diol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.76]
synonym: "L(+)-2,3-butanediol dehydrogenase (L-acetoin forming)" EXACT [EC:1.1.1.76]
synonym: "L-BDH" RELATED [EC:1.1.1.76]
synonym: "L-butanediol dehydrogenase activity" EXACT [EC:1.1.1.76]
xref: EC:1.1.1.76
xref: KEGG:R03707
xref: MetaCyc:SS-BUTANEDIOL-DEHYDROGENASE-RXN
xref: RHEA:12187
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047513
name: 1,2-alpha-L-fucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + methyl-2-alpha-L-fucopyranosyl-beta-D-galactoside = L-fucose + methyl beta-D-galactoside." [EC:3.2.1.63, MetaCyc:12-ALPHA-L-FUCOSIDASE-RXN]
synonym: "2-alpha-L-fucopyranosyl-beta-D-galactoside fucohydrolase activity" EXACT [EC:3.2.1.63]
synonym: "almond emulsin fucosidase activity" EXACT [EC:3.2.1.63]
synonym: "almond emulsin fucosidase II activity" NARROW [EC:3.2.1.63]
synonym: "alpha-(1->2)-L-fucosidase activity" EXACT [EC:3.2.1.63]
xref: EC:3.2.1.63
xref: MetaCyc:12-ALPHA-L-FUCOSIDASE-RXN
xref: RHEA:10819
is_a: GO:0004560 ! alpha-L-fucosidase activity

[Term]
id: GO:0047514
name: 1,3-beta-D-glucan phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: [(1->3)-beta-D-glucosyl](n) + phosphate = [(1->3)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate; substrates include laminarin." [EC:2.4.1.97, MetaCyc:13-BETA-GLUCAN-PHOSPHORYLASE-RXN]
synonym: "1,3-beta-D-glucan:orthophosphate glucosyltransferase activity" EXACT [EC:2.4.1.97]
synonym: "1,3-beta-D-glucan:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.97]
synonym: "1,3-beta-glucan phosphorylase activity" EXACT []
synonym: "laminarin phosphorylase activity" RELATED [EC:2.4.1.97]
synonym: "laminarin phosphoryltransferase activity" EXACT [EC:2.4.1.97]
xref: EC:2.4.1.97
xref: MetaCyc:13-BETA-GLUCAN-PHOSPHORYLASE-RXN
is_a: GO:0004645 ! phosphorylase activity

[Term]
id: GO:0047515
name: 1,3-beta-oligoglucan phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: [oligomeric (1->3)-beta-D-glucosyl](n) + phosphate = [(1->3)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate." [EC:2.4.1.30, MetaCyc:13-BETA-OLIGOGLUCAN-PHOSPHORYLASE-RXN]
synonym: "1,3-beta-D-oligoglucan:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.30]
synonym: "beta-1,3-oligoglucan phosphorylase activity" EXACT [EC:2.4.1.30]
synonym: "beta-1,3-oligoglucan:orthophosphate glucosyltransferase II activity" EXACT [EC:2.4.1.30]
xref: EC:2.4.1.30
xref: MetaCyc:13-BETA-OLIGOGLUCAN-PHOSPHORYLASE-RXN
is_a: GO:0004645 ! phosphorylase activity

[Term]
id: GO:0047516
name: 1,3-propanediol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: propane-1,3-diol + NAD+ = 3-hydroxypropanal + NADH + H+." [EC:1.1.1.202, MetaCyc:13-PROPANEDIOL-DEHYDROGENASE-RXN]
subset: gosubset_prok
synonym: "1,3-PD:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.202]
synonym: "1,3-propanediol oxidoreductase activity" EXACT [EC:1.1.1.202]
synonym: "1,3-propanediol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.202]
synonym: "3-hydroxypropionaldehyde reductase activity" EXACT [EC:1.1.1.202]
synonym: "propane-1,3-diol:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.202]
xref: EC:1.1.1.202
xref: MetaCyc:13-PROPANEDIOL-DEHYDROGENASE-RXN
xref: RHEA:23191
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047517
name: 1,4-beta-D-xylan synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-D-xylose + [(1->4)-beta-D-xylan](n) = UDP + [(1->4)-beta-D-xylan](n+1)." [EC:2.4.2.24, MetaCyc:1\,4-BETA-D-XYLAN-SYNTHASE-RXN]
synonym: "1,4-beta-xylan synthase activity" EXACT [EC:2.4.2.24]
synonym: "UDP-D-xylose:1,4-beta-D-xylan 4-beta-D-xylosyltransferase activity" EXACT [EC:2.4.2.24]
synonym: "uridine diphosphoxylose-1,4-beta-xylan xylosyltransferase activity" EXACT [EC:2.4.2.24]
synonym: "xylan synthase activity" EXACT [EC:2.4.2.24]
synonym: "xylan synthetase activity" EXACT [EC:2.4.2.24]
xref: EC:2.4.2.24
xref: MetaCyc:RXN-9104
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0047518
name: 1-methyladenosine nucleosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-methyladenosine + H(2)O = 1-methyladenine + ribofuranose." [EC:3.2.2.13, RHEA:12868]
synonym: "1-methyladenosine hydrolase activity" EXACT [EC:3.2.2.13]
synonym: "1-methyladenosine ribohydrolase activity" EXACT [EC:3.2.2.13]
xref: EC:3.2.2.13
xref: KEGG:R03885
xref: MetaCyc:1-METHYLADENOSINE-NUCLEOSIDASE-RXN
xref: RHEA:12868
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0047519
name: quinate dehydrogenase (quinone) activity
namespace: molecular_function
def: "Catalysis of the reaction: (-)-quinate + pyrroloquinoline-quinone = (-)-3-dehydroquinate + pyrroloquinoline-quinol." [RHEA:23675]
subset: gosubset_prok
synonym: "NAD(P)-independent quinate dehydrogenase activity" EXACT [EC:1.1.5.8]
synonym: "quinate:pyrroloquinoline-quinone 5-oxidoreductase activity" EXACT [EC:1.1.5.8]
synonym: "quinate:quinone 3-oxidoreductase activity" EXACT systematic_synonym [EC:1.1.5.8]
xref: EC:1.1.5.8
xref: KEGG:R01873
xref: MetaCyc:1.1.99.25-RXN
xref: RHEA:23675
is_a: GO:0016901 ! oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor

[Term]
id: GO:0047520
name: 11-cis-retinyl-palmitate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 11-cis-retinyl palmitate + H(2)O = 11-cis-retinol + H(+) + palmitate." [EC:3.1.1.63, RHEA:19700]
synonym: "11-cis-retinol palmitate esterase activity" EXACT [EC:3.1.1.63]
synonym: "11-cis-retinyl-palmitate acylhydrolase activity" EXACT [EC:3.1.1.63]
synonym: "RPH" RELATED [EC:3.1.1.63]
xref: EC:3.1.1.63
xref: KEGG:R03049
xref: MetaCyc:11-CIS-RETINYL-PALMITATE-HYDROLASE-RXN
xref: RHEA:19700
is_a: GO:0052689 ! carboxylic ester hydrolase activity
relationship: part_of GO:0042572 ! retinol metabolic process

[Term]
id: GO:0047521
name: 3alpha,7alpha,12beta-trihydroxy-5beta-cholanate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3alpha,7alpha,12beta-trihydroxy-5beta-cholanate + NADP(+) = 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH." [EC:1.1.1.238, RHEA:21427]
synonym: "12-beta-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.238]
synonym: "12beta-hydroxy steroid (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" BROAD [EC:1.1.1.238]
synonym: "12beta-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.238]
synonym: "12beta-hydroxysteroid:NADP+ 12-oxidoreductase activity" BROAD [EC:1.1.1.238]
xref: EC:1.1.1.238
xref: KEGG:R03495
xref: MetaCyc:12-BETA-HYDROXYSTEROID-DEHYDROGENASE-RXN
xref: RHEA:21427
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047522
name: 15-oxoprostaglandin 13-oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprostanoate + NAD(P)+ -> (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprosta-13-enoate + NAD(P)H + H+." [EC:1.3.1.48, KEGG:R04556, KEGG:R04557, MetaCyc:15-OXOPROSTAGLANDIN-13-REDUCTASE-RXN]
comment: Note that this is the reverse of the reaction described in '13-prostaglandin reductase activity ; GO:0036132'.
synonym: "(5Z)-(15S)-11alpha-hydroxy-9,15-dioxoprostanoate:NAD(P)+ delta13-oxidoreductase activity" EXACT [EC:1.3.1.48]
xref: EC:1.3.1.48
xref: KEGG:R04556
xref: KEGG:R04557
xref: MetaCyc:15-OXOPROSTAGLANDIN-13-REDUCTASE-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047524
name: 16-hydroxysteroid epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 16-alpha-hydroxysteroid = 16-beta-hydroxysteroid." [EC:5.1.99.2, MetaCyc:16-HYDROXYSTEROID-EPIMERASE-RXN]
synonym: "16-hydroxysteroid 16-epimerase activity" EXACT [EC:5.1.99.2]
xref: EC:5.1.99.2
xref: MetaCyc:16-HYDROXYSTEROID-EPIMERASE-RXN
is_a: GO:0016854 ! racemase and epimerase activity

[Term]
id: GO:0047525
name: 2'-hydroxydaidzein reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2'-hydroxydihydrodaidzein + NADP+ = 2'-hydroxydaidzein + NADPH + H+." [EC:1.3.1.51, MetaCyc:2'-HYDROXYDAIDZEIN-REDUCTASE-RXN]
synonym: "2'-hydroxy-2,3-dihydrodaidzein:NADP+ 2'-oxidoreductase activity" EXACT [EC:1.3.1.51]
synonym: "2'-hydroxydihydrodaidzein:NADP(+) 2'-oxidoreductase activity" EXACT [EC:1.3.1.51]
synonym: "2'-hydroxydihydrodaidzein:NADP+ 2'-oxidoreductase activity" EXACT [EC:1.3.1.51]
synonym: "HDR activity" EXACT [EC:1.3.1.51]
synonym: "NADPH:2'-hydroxydaidzein oxidoreductase activity" EXACT [EC:1.3.1.51]
xref: EC:1.3.1.51
xref: MetaCyc:RXN-4502
xref: RHEA:17148
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047526
name: 2'-hydroxyisoflavone reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: vestitone + NADP+ = 2'-hydroxyformononetin + NADPH + H+." [EC:1.3.1.45, MetaCyc:2-HYDROXYISOFLAVONE-REDUCTASE-RXN]
subset: gosubset_prok
synonym: "2',7-dihydroxy-4',5'-methylenedioxyisoflavone reductase activity" EXACT [EC:1.3.1.45]
synonym: "isoflavone reductase activity" EXACT [EC:1.3.1.45]
synonym: "NADPH:2'-hydroxyisoflavone oxidoreductase activity" EXACT [EC:1.3.1.45]
synonym: "vestitone:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.45]
xref: EC:1.3.1.45
xref: MetaCyc:2-HYDROXYISOFLAVONE-REDUCTASE-RXN
xref: RHEA:22563
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047527
name: 2,3-dihydroxybenzoate-serine ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 2,3-dihydroxybenzoate + L-serine = products of ATP breakdown + N-(2,3-dihydroxybenzoyl)-L-serine." [EC:6.3.2.14, MetaCyc:1\,3-DIHYDROXYBENZOATE--SERINE-LIGASE-RXN]
synonym: "2,3-dihydroxybenzoate:L-serine ligase activity" EXACT [EC:6.3.2.14]
synonym: "2,3-dihydroxybenzoylserine synthetase activity" EXACT [EC:6.3.2.14]
synonym: "N-(2,3-dihydroxybenzoyl)-serine synthetase activity" EXACT [EC:6.3.2.14]
xref: EC:6.3.2.14
xref: MetaCyc:23-DIHYDROXYBENZOATE--SERINE-LIGASE-RXN
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0047528
name: 2,3-dihydroxyindole 2,3-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-dihydroxyindole + O(2) = anthranilate + CO(2) + H(+)." [EC:1.13.11.23, RHEA:19448]
synonym: "2,3-dihydroxyindole:oxygen 2,3-oxidoreductase (decyclizing) activity" EXACT [EC:1.13.11.23]
xref: EC:1.13.11.23
xref: KEGG:R00983
xref: MetaCyc:23-DIHYDROXYINDOLE-23-DIOXYGENASE-RXN
xref: RHEA:19448
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0047529
name: 2,3-dimethylmalate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2R,3S)-2,3-dimethylmalate = propanoate + pyruvate." [EC:4.1.3.32, RHEA:10475]
synonym: "(2R,3S)-2,3-dimethylmalate pyruvate-lyase (propanoate-forming)" EXACT [EC:4.1.3.32]
synonym: "(2R,3S)-2,3-dimethylmalate pyruvate-lyase activity" EXACT [EC:4.1.3.32]
synonym: "2,3-dimethylmalate pyruvate-lyase activity" EXACT [EC:4.1.3.32]
xref: EC:4.1.3.32
xref: KEGG:R01355
xref: MetaCyc:23-DIMETHYLMALATE-LYASE-RXN
xref: RHEA:10475
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0047530
name: 2,4-diaminopentanoate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4-diaminopentanoate + H2O + NAD(P)+ = 2-amino-4-oxopentanoate + NH3 + NAD(P)H + H+." [EC:1.4.1.12, MetaCyc:24-DIAMINOPENTANOATE-DEHYDROGENASE-RXN]
synonym: "2,4-diaminopentanoate:NAD(P)+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.12]
synonym: "2,4-diaminopentanoic acid C4 dehydrogenase activity" EXACT [EC:1.4.1.12]
xref: EC:1.4.1.12
xref: MetaCyc:24-DIAMINOPENTANOATE-DEHYDROGENASE-RXN
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047531
name: 2,5-diaminovalerate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + ornithine = 5-amino-2-oxopentanoate + L-glutamate." [EC:2.6.1.8, RHEA:16020]
synonym: "2,5-diaminopentanoate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.8]
synonym: "2,5-diaminovalerate aminotransferase activity" EXACT []
synonym: "diamino acid aminotransferase activity" EXACT [EC:2.6.1.8]
synonym: "diamino-acid aminotransferase activity" RELATED [EC:2.6.1.8]
synonym: "diamino-acid transaminase activity" EXACT [EC:2.6.1.8]
xref: EC:2.6.1.8
xref: KEGG:R03248
xref: MetaCyc:25-DIAMINOVALERATE-AMINOTRANSFERASE-RXN
xref: RHEA:16020
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047532
name: 2,5-dioxopiperazine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,5-dioxopiperazine + H(2)O = glycylglycine." [EC:3.5.2.13, RHEA:21811]
synonym: "2,5-dioxopiperazine amidohydrolase activity" EXACT [EC:3.5.2.13]
synonym: "cyclo(Gly-Gly) hydrolase activity" EXACT [EC:3.5.2.13]
synonym: "cyclo(glycylglycine) hydrolase activity" EXACT [EC:3.5.2.13]
xref: EC:3.5.2.13
xref: KEGG:R03810
xref: MetaCyc:25-DIOXOPIPERAZINE-HYDROLASE-RXN
xref: RHEA:21811
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0047533
name: 2,5-dioxovalerate dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,5-dioxopentanoate + NADP+ + H2O = 2-oxoglutarate + NADPH + H+." [EC:1.2.1.26, IMG:03338, MetaCyc:25-DIOXOVALERATE-DEHYDROGENASE-RXN]
synonym: "2,5-dioxopentanoate:NADP+ 5-oxidoreductase activity" EXACT [EC:1.2.1.26]
synonym: "2-oxoglutarate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.26]
synonym: "alpha-ketoglutaric semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.26]
xref: EC:1.2.1.26
xref: MetaCyc:25-DIOXOVALERATE-DEHYDROGENASE-RXN
xref: RHEA:11299
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047534
name: 2-acetolactate mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-acetolactate = 3-hydroxy-3-methyl-2-oxobutanoate." [EC:5.4.99.3, MetaCyc:2-ACETOLACTATE-MUTASE-RXN]
synonym: "2-acetolactate methylmutase activity" EXACT [EC:5.4.99.3]
synonym: "acetohydroxy acid isomerase activity" BROAD [EC:5.4.99.3]
synonym: "acetolactate mutase activity" EXACT [EC:5.4.99.3]
xref: EC:5.4.99.3
xref: MetaCyc:2-ACETOLACTATE-MUTASE-RXN
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0047535
name: 2-alkyn-1-ol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-butyne-1,4-diol + NAD(+) = 4-hydroxy-2-butynal + H(+) + NADH." [EC:1.1.1.165, RHEA:19104]
synonym: "2-butyne-1,4-diol:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.165]
xref: EC:1.1.1.165
xref: KEGG:R03963
xref: MetaCyc:2-ALKYN-1-OL-DEHYDROGENASE-RXN
xref: RHEA:19104
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047536
name: 2-aminoadipate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + L-2-aminoadipate = 2-oxoadipate + L-glutamate." [EC:2.6.1.39, RHEA:12604]
synonym: "2-aminoadipate aminotransferase activity" EXACT []
synonym: "2-aminoadipic aminotransferase activity" EXACT [EC:2.6.1.39]
synonym: "alpha-aminoadipate aminotransferase activity" EXACT [EC:2.6.1.39]
synonym: "glutamate-alpha-ketoadipate transaminase activity" EXACT [EC:2.6.1.39]
synonym: "glutamic-ketoadipic transaminase activity" EXACT [EC:2.6.1.39]
synonym: "L-2-aminoadipate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.39]
xref: EC:2.6.1.39
xref: KEGG:R01939
xref: MetaCyc:2-AMINOADIPATE-AMINOTRANSFERASE-RXN
xref: Reactome:REACT_102003 "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate, Rattus norvegicus"
xref: Reactome:REACT_108084 "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate, Dictyostelium discoideum"
xref: Reactome:REACT_110718 "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate, Drosophila melanogaster"
xref: Reactome:REACT_112934 "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate, Escherichia coli"
xref: Reactome:REACT_113111 "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate, Staphylococcus aureus N315"
xref: Reactome:REACT_113427 "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate, Saccharomyces cerevisiae"
xref: Reactome:REACT_114940 "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate, Schizosaccharomyces pombe"
xref: Reactome:REACT_2065 "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate, Homo sapiens"
xref: Reactome:REACT_21297 "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate, Homo sapiens"
xref: Reactome:REACT_29354 "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate, Sus scrofa"
xref: Reactome:REACT_30193 "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate, Gallus gallus"
xref: Reactome:REACT_80429 "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate, Mus musculus"
xref: Reactome:REACT_85578 "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate, Xenopus tropicalis"
xref: Reactome:REACT_85893 "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate, Canis familiaris"
xref: Reactome:REACT_90994 "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate, Bos taurus"
xref: Reactome:REACT_92051 "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate, Danio rerio"
xref: Reactome:REACT_94119 "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate, Taeniopygia guttata"
xref: RHEA:12604
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047537
name: 2-aminohexanoate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-2-aminohexanoate + 2-oxoglutarate = 2-oxohexanoate + L-glutamate." [EC:2.6.1.67, MetaCyc:2-AMINOHEXANOATE-AMINOTRANSFERASE-RXN]
synonym: "2-aminohexanoate aminotransferase activity" EXACT []
synonym: "L-2-aminohexanoate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.67]
synonym: "leucine L-norleucine: 2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.67]
synonym: "norleucine (leucine) aminotransferase activity" EXACT [EC:2.6.1.67]
synonym: "norleucine aminotransferase activity" EXACT [EC:2.6.1.67]
synonym: "norleucine transaminase activity" EXACT [EC:2.6.1.67]
xref: EC:2.6.1.67
xref: MetaCyc:2-AMINOHEXANOATE-AMINOTRANSFERASE-RXN
xref: RHEA:23603
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047538
name: 2-carboxy-D-arabinitol-1-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-carboxy-D-arabinitol 1-phosphate + H(2)O = 2-carboxy-D-arabinitol + phosphate." [EC:3.1.3.63, RHEA:17840]
synonym: "2-carboxy-D-arabinitol 1-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.63]
synonym: "2-carboxy-D-arabinitol-1-phosphate 1-phosphohydrolase activity" EXACT [EC:3.1.3.63]
synonym: "2-carboxyarabinitol 1-phosphatase activity" EXACT [EC:3.1.3.63]
xref: EC:3.1.3.63
xref: KEGG:R04167
xref: MetaCyc:2-CARBOXY-D-ARABINITOL-1-PHOSPHATASE-RXN
xref: RHEA:17840
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0047539
name: 2-deoxyglucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + a 2-deoxy-alpha-D-glucoside = 2-deoxy-D-glucose + an alcohol." [EC:3.2.1.112, MetaCyc:2-DEOXYGLUCOSIDASE-RXN]
synonym: "2-deoxy-alpha-D-glucosidase activity" EXACT [EC:3.2.1.112]
synonym: "2-deoxy-alpha-D-glucoside deoxyglucohydrolase activity" EXACT [EC:3.2.1.112]
synonym: "2-deoxy-alpha-glucosidase activity" EXACT [EC:3.2.1.112]
xref: EC:3.2.1.112
xref: MetaCyc:2-DEOXYGLUCOSIDASE-RXN
is_a: GO:0015926 ! glucosidase activity

[Term]
id: GO:0047540
name: 2-enoate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: butanoate + NAD+ = 2-butenoate + NADH + H+." [EC:1.3.1.31, MetaCyc:2-ENOATE-REDUCTASE-RXN]
subset: gosubset_prok
synonym: "butanoate:NAD+ delta2-oxidoreductase activity" EXACT [EC:1.3.1.31]
synonym: "enoate reductase activity" EXACT [EC:1.3.1.31]
xref: EC:1.3.1.31
xref: MetaCyc:2-ENOATE-REDUCTASE-RXN
xref: RHEA:10203
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047541
name: 2-furoate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-furoate + ATP + CoA = 2-furoyl-CoA + AMP + diphosphate + H(+)." [EC:6.2.1.31, RHEA:19272]
synonym: "2-furoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.31]
synonym: "2-furoyl coenzyme A synthetase activity" EXACT [EC:6.2.1.31]
xref: EC:6.2.1.31
xref: KEGG:R02986
xref: MetaCyc:2-FUROATE--COA-LIGASE-RXN
xref: RHEA:19272
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0047542
name: 2-furoyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-furoyl-CoA + A + H(2)O = 5-hydroxy-2-furoyl-CoA + AH(2) + H(+)." [EC:1.3.99.8, RHEA:21483]
synonym: "2-furoyl coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.8]
synonym: "2-furoyl coenzyme A hydroxylase activity" EXACT [EC:1.3.99.8]
synonym: "2-furoyl-CoA:(acceptor) 5-oxidoreductase (hydroxylating)" EXACT [EC:1.3.99.8]
synonym: "2-furoyl-CoA:acceptor 5-oxidoreductase (hydroxylating)" EXACT [EC:1.3.99.8]
synonym: "furoyl-CoA hydroxylase activity" EXACT [EC:1.3.99.8]
xref: EC:1.3.99.8
xref: KEGG:R02987
xref: MetaCyc:2-FUROYL-COA-DEHYDROGENASE-RXN
xref: RHEA:21483
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0047543
name: 2-hexadecenal reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP(+) + palmitaldehyde = trans-hexadec-2-enal + H(+) + NADPH." [EC:1.3.1.27, RHEA:12447]
synonym: "hexadecanal: NADP+ oxidoreductase activity" EXACT [EC:1.3.1.27]
synonym: "hexadecanal:NADP+ delta2-oxidoreductase activity" EXACT [EC:1.3.1.27]
xref: EC:1.3.1.27
xref: KEGG:R02463
xref: MetaCyc:2-HEXADECENAL-REDUCTASE-RXN
xref: RHEA:12447
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047544
name: 2-hydroxybiphenyl 3-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: biphenyl-2-ol + H(+) + NADH + O(2) = biphenyl-2,3-diol + H(2)O + NAD(+)." [EC:1.14.13.44, RHEA:11999]
synonym: "2-hydroxybiphenyl,NADH:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.44]
xref: EC:1.14.13.44
xref: KEGG:R03964
xref: MetaCyc:2-HYDROXYBIPHENYL-3-MONOOXYGENASE-RXN
xref: RHEA:11999
xref: UM-BBD_reactionID:r1423
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047545
name: 2-hydroxyglutarate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor." [EC:1.1.99.2, MetaCyc:2-HYDROXYGLUTARATE-DEHYDROGENASE-RXN]
subset: gosubset_prok
synonym: "(S)-2-hydroxyglutarate:(acceptor) 2-oxidoreductase" EXACT [EC:1.1.99.2]
synonym: "(S)-2-hydroxyglutarate:acceptor 2-oxidoreductase" EXACT [EC:1.1.99.2]
synonym: "alpha-hydroxyglutarate dehydrogenase (NAD+ specific)" NARROW [EC:1.1.99.2]
synonym: "alpha-hydroxyglutarate dehydrogenase activity" EXACT [EC:1.1.99.2]
synonym: "alpha-hydroxyglutarate oxidoreductase activity" EXACT [EC:1.1.99.2]
synonym: "hydroxyglutaric dehydrogenase activity" EXACT [EC:1.1.99.2]
synonym: "L-alpha-hydroxyglutarate dehydrogenase activity" EXACT [EC:1.1.99.2]
synonym: "L-alpha-hydroxyglutarate:NAD+ 2-oxidoreductase" NARROW [EC:1.1.99.2]
xref: EC:1.1.99.2
xref: MetaCyc:2-HYDROXYGLUTARATE-DEHYDROGENASE-RXN
xref: RHEA:21255
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0047546
name: 2-hydroxypyridine 5-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxypyridine + AH(2) + O(2) = 2,5-dihydroxypyridine + A + H(2)O." [EC:1.14.99.26, RHEA:16976]
synonym: "2-hydroxypyridine oxygenase activity" EXACT [EC:1.14.99.26]
synonym: "2-hydroxypyridine,hydrogen-donor:oxygen oxidoreductase (5-hydroxylating)" EXACT [EC:1.14.99.26]
xref: EC:1.14.99.26
xref: KEGG:R03206
xref: MetaCyc:2-HYDROXYPYRIDINE-5-MONOOXYGENASE-RXN
xref: RHEA:16976
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0047547
name: 2-methylcitrate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2S,3S)-2-methylcitrate = cis-2-methylaconitate + H(2)O." [EC:4.2.1.79, RHEA:17728]
subset: gosubset_prok
synonym: "(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase [(Z)-but-2-ene-1,2,3-tricarboxylate-forming]" RELATED [EC:4.2.1.79]
synonym: "2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase activity" EXACT [EC:4.2.1.79]
synonym: "2-methylcitrate hydro-lyase activity" EXACT [EC:4.2.1.79]
synonym: "prpD" RELATED [EC:4.2.1.79]
xref: EC:4.2.1.79
xref: KEGG:R04424
xref: MetaCyc:2-METHYLCITRATE-DEHYDRATASE-RXN
xref: RHEA:17728
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047548
name: 2-methyleneglutarate mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-methyleneglutarate = 2-methylene-3-methylsuccinate." [EC:5.4.99.4, RHEA:13796]
subset: gosubset_prok
synonym: "2-methyleneglutarate carboxy-methylenemethylmutase activity" EXACT [EC:5.4.99.4]
synonym: "alpha-methyleneglutarate mutase activity" EXACT [EC:5.4.99.4]
xref: EC:5.4.99.4
xref: KEGG:R03908
xref: MetaCyc:2-METHYLENEGLUTARATE-MUTASE-RXN
xref: RHEA:13796
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0047549
name: 2-nitrophenol 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-nitrophenol + 2 H(+) + 2 NADPH + O(2) = catechol + H(2)O + 2 NADP(+) + nitrite." [EC:1.14.13.31, RHEA:19460]
synonym: "2-nitrophenol oxygenase activity" EXACT [EC:1.14.13.31]
synonym: "2-nitrophenol,NADPH:oxygen 2-oxidoreductase (2-hydroxylating, nitrite-forming)" EXACT [EC:1.14.13.31]
synonym: "nitrophenol oxygenase activity" BROAD [EC:1.14.13.31]
xref: EC:1.14.13.31
xref: KEGG:R00828
xref: MetaCyc:2-NITROPHENOL-2-MONOOXYGENASE-RXN
xref: RHEA:19460
xref: UM-BBD_reactionID:r1494
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047550
name: 2-oxoadipate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxyadipate + NAD(+) = 2-oxoadipate + H(+) + NADH." [EC:1.1.1.172, RHEA:14796]
synonym: "2-hydroxyadipate:NAD+ 2-oxidoreductase activity" EXACT [EC:1.1.1.172]
synonym: "2-ketoadipate reductase activity" EXACT [EC:1.1.1.172]
synonym: "alpha-ketoadipate reductase activity" EXACT [EC:1.1.1.172]
xref: EC:1.1.1.172
xref: KEGG:R01932
xref: MetaCyc:2-OXOADIPATE-REDUCTASE-RXN
xref: RHEA:14796
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047551
name: 2-oxoaldehyde dehydrogenase (NAD) activity
namespace: molecular_function
def: "Catalysis of the reaction: a 2-oxoaldehyde + NAD+ + H2O = a 2-oxo acid + NADH + H+." [EC:1.2.1.23, MetaCyc:2-OXOALDEHYDE-DEHYDROGENASE-NAD+-RXN]
synonym: "2-ketoaldehyde dehydrogenase" BROAD [EC:1.2.1.23]
synonym: "2-oxoaldehyde dehydrogenase (NAD+)" EXACT [EC:1.2.1.23]
synonym: "2-oxoaldehyde:NAD+ 2-oxidoreductase activity" EXACT [EC:1.2.1.23]
synonym: "alpha-ketoaldehyde dehydrogenase activity" BROAD [EC:1.2.1.23]
synonym: "methylglyoxal dehydrogenase activity" BROAD [EC:1.2.1.23]
synonym: "NAD-dependent alpha-ketoaldehyde dehydrogenase activity" EXACT [EC:1.2.1.23]
synonym: "NAD-linked alpha-ketoaldehyde dehydrogenase activity" EXACT [EC:1.2.1.23]
xref: EC:1.2.1.23
xref: MetaCyc:2-OXOALDEHYDE-DEHYDROGENASE-NAD+-RXN
xref: RHEA:22279
xref: Wikipedia:2-oxoaldehyde_dehydrogenase_(NAD+)
is_a: GO:0004029 ! aldehyde dehydrogenase (NAD) activity

[Term]
id: GO:0047552
name: 2-oxoaldehyde dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: a 2-oxoaldehyde + NADP+ + H2O = a 2-oxo acid + NADPH + H+." [EC:1.2.1.49, MetaCyc:2-OXOALDEHYDE-DEHYDROGENASE-NADP+-RXN]
synonym: "2-ketoaldehyde dehydrogenase" BROAD [EC:1.2.1.49]
synonym: "2-oxoaldehyde:NADP+ 2-oxidoreductase activity" EXACT [EC:1.2.1.49]
synonym: "alpha-ketoaldehyde dehydrogenase activity" BROAD [EC:1.2.1.49]
synonym: "methylglyoxal dehydrogenase activity" BROAD [EC:1.2.1.49]
synonym: "NADP-dependent alpha-ketoaldehyde dehydrogenase activity" EXACT [EC:1.2.1.49]
synonym: "NADP-linked alpha-ketoaldehyde dehydrogenase activity" EXACT [EC:1.2.1.49]
xref: EC:1.2.1.49
xref: MetaCyc:2-OXOALDEHYDE-DEHYDROGENASE-NADP+-RXN
xref: RHEA:18132
is_a: GO:0033721 ! aldehyde dehydrogenase (NADP+) activity

[Term]
id: GO:0047553
name: 2-oxoglutarate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + CoA + oxidized ferredoxin = succinyl-CoA + CO2 + reduced ferredoxin." [EC:1.2.7.3, MetaCyc:2-OXOGLUTARATE-SYNTHASE-RXN]
subset: gosubset_prok
synonym: "2-ketoglutarate ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.3]
synonym: "2-oxoglutarate ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.3]
synonym: "2-oxoglutarate:ferredoxin 2-oxidoreductase (CoA-succinylating)" EXACT [EC:1.2.7.3]
synonym: "2-oxoglutarate:ferredoxin 2-oxidoreductase (decarboxylating)" EXACT [EC:1.2.7.3]
synonym: "2-oxoglutarate:ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.3]
synonym: "alpha-ketoglutarate synthase activity" EXACT [EC:1.2.7.3]
synonym: "alpha-ketoglutarate-ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.3]
synonym: "KGOR activity" EXACT [EC:1.2.7.3]
xref: EC:1.2.7.3
xref: MetaCyc:2-OXOGLUTARATE-SYNTHASE-RXN
is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0047554
name: 2-pyrone-4,6-dicarboxylate lactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxo-2H-pyran-4,6-dicarboxylate + H(2)O = 4-carboxy-2-hydroxyhexa-2,4-dienedioate + H(+)." [EC:3.1.1.57, RHEA:10647]
subset: gosubset_prok
synonym: "2-pyrone-4,6-dicarboxylate lactonohydrolase activity" EXACT [EC:3.1.1.57]
xref: EC:3.1.1.57
xref: KEGG:R04277
xref: MetaCyc:RXN-2462
xref: RHEA:10647
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0047555
name: 3',5'-cyclic-GMP phosphodiesterase activity
namespace: molecular_function
alt_id: GO:0004116
def: "Catalysis of the reaction: guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate." [EC:3.1.4.35, MetaCyc:35-CYCLIC-GMP-PHOSPHODIESTERASE-RXN]
synonym: "3',5' cyclic-GMP phosphodiesterase activity" EXACT []
synonym: "3',5'-cyclic-GMP 5'-nucleotidohydrolase activity" EXACT [EC:3.1.4.35]
synonym: "cGMP phosphodiesterase activity" EXACT []
synonym: "cGMP-PDE" RELATED [EC:3.1.4.35]
synonym: "cGMP-specific phosphodiesterase activity" EXACT []
synonym: "cyclic 3',5'-GMP phosphodiesterase activity" EXACT [EC:3.1.4.35]
synonym: "cyclic GMP phosphodiesterase activity" EXACT []
synonym: "cyclic guanosine 3',5'-monophosphate phosphodiesterase activity" EXACT [EC:3.1.4.35]
synonym: "cyclic guanosine 3',5'-phosphate phosphodiesterase activity" EXACT [EC:3.1.4.35]
synonym: "guanosine cyclic 3',5'-phosphate phosphodiesterase activity" EXACT []
xref: EC:3.1.4.35
xref: MetaCyc:35-CYCLIC-GMP-PHOSPHODIESTERASE-RXN
xref: Reactome:REACT_101417 "cGMP is degraded by PDEs, Xenopus tropicalis"
xref: Reactome:REACT_103009 "cGMP is degraded by PDEs, Mus musculus"
xref: Reactome:REACT_103279 "cGMP is degraded by PDEs, Caenorhabditis elegans"
xref: Reactome:REACT_115190 "cGMP is degraded by PDEs, Plasmodium falciparum"
xref: Reactome:REACT_23959 "cGMP is degraded by PDEs, Homo sapiens"
xref: Reactome:REACT_79830 "cGMP is degraded by PDEs, Taeniopygia guttata"
xref: Reactome:REACT_79860 "cGMP is degraded by PDEs, Bos taurus"
xref: Reactome:REACT_82291 "cGMP is degraded by PDEs, Gallus gallus"
xref: Reactome:REACT_84973 "cGMP is degraded by PDEs, Canis familiaris"
xref: Reactome:REACT_86181 "cGMP is degraded by PDEs, Drosophila melanogaster"
xref: Reactome:REACT_87332 "cGMP is degraded by PDEs, Dictyostelium discoideum"
xref: Reactome:REACT_94300 "cGMP is degraded by PDEs, Sus scrofa"
xref: Reactome:REACT_96221 "cGMP is degraded by PDEs, Danio rerio"
xref: Reactome:REACT_96487 "cGMP is degraded by PDEs, Rattus norvegicus"
xref: RHEA:16960
is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity

[Term]
id: GO:0047556
name: 3,4-dihydroxyphthalate decarboxylase activity
namespace: molecular_function
alt_id: GO:0034913
def: "Catalysis of the reaction: 3,4-dihydroxyphthalate + H(+) = 3,4-dihydroxybenzoate + CO(2)." [EC:4.1.1.69, RHEA:18604]
synonym: "3,4-dihydroxyphthalate 2-decarboxylase activity" EXACT []
synonym: "3,4-dihydroxyphthalate carboxy-lyase (3,4-dihydroxybenzoate-forming)" EXACT [EC:4.1.1.69]
synonym: "3,4-dihydroxyphthalate carboxy-lyase activity" EXACT [EC:4.1.1.69]
xref: EC:4.1.1.69
xref: KEGG:R01634
xref: MetaCyc:34-DIHYDROXYPHTHALATE-DECARBOXYLASE-RXN
xref: RHEA:18604
xref: UM-BBD_reactionID:r1447
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047557
name: 3-aci-nitropropanoate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-aci-nitropropanoate + H(2)O + O(2) = 3-oxopropanoate + H(2)O(2) + nitrite." [EC:1.7.3.5, RHEA:22375]
synonym: "3-aci-nitropropanoate:oxygen oxidoreductase activity" EXACT [EC:1.7.3.5]
synonym: "propionate-3-nitronate oxidase activity" EXACT [EC:1.7.3.5]
xref: EC:1.7.3.5
xref: KEGG:R01609
xref: MetaCyc:3-ACI-NITROPROPANOATE-OXIDASE-RXN
xref: RHEA:22375
is_a: GO:0016663 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor

[Term]
id: GO:0047558
name: 3-cyanoalanine hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-asparagine = 3-cyano-L-alanine + H(2)O + H(+)." [EC:4.2.1.65, RHEA:15388]
synonym: "beta-CNA nitrilase activity" EXACT [EC:4.2.1.65]
synonym: "beta-CNAla hydrolase activity" EXACT [EC:4.2.1.65]
synonym: "beta-cyanoalanine hydratase activity" EXACT [EC:4.2.1.65]
synonym: "beta-cyanoalanine hydrolase activity" EXACT [EC:4.2.1.65]
synonym: "L-asparagine hydro-lyase (3-cyanoalanine-forming)" EXACT [EC:4.2.1.65]
synonym: "L-asparagine hydro-lyase activity" EXACT [EC:4.2.1.65]
xref: EC:4.2.1.65
xref: KEGG:R01267
xref: MetaCyc:3-CYANOALANINE-HYDRATASE-RXN
xref: RHEA:15388
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047559
name: 3-dehydro-L-gulonate 2-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-dehydro-L-gulonate + NAD(P)+ = (4R,5S)-4,5,6-trihydroxy-2,3-dioxohexanoate + NAD(P)H + H+." [EC:1.1.1.130, MetaCyc:3-DEHYDRO-L-GULONATE-2-DEHYDROGENASE-RXN]
synonym: "2,3-diketo-L-gulonate reductase activity" EXACT [EC:1.1.1.130]
synonym: "3-dehydro-L-gulonate:NAD(P)+ 2-oxidoreductase activity" EXACT [EC:1.1.1.130]
synonym: "3-keto-L-gulonate dehydrogenase activity" EXACT [EC:1.1.1.130]
synonym: "3-ketogulonate dehydrogenase activity" EXACT [EC:1.1.1.130]
xref: EC:1.1.1.130
xref: MetaCyc:3-DEHYDRO-L-GULONATE-2-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047560
name: 3-dehydrosphinganine reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP(+) + sphinganine = 3-dehydrosphinganine + H(+) + NADPH." [EC:1.1.1.102, RHEA:22643]
synonym: "3-ketosphinganine reductase activity" EXACT [EC:1.1.1.102]
synonym: "3-oxosphinganine reductase activity" EXACT [EC:1.1.1.102]
synonym: "3-oxosphinganine:NADPH oxidoreductase activity" EXACT [EC:1.1.1.102]
synonym: "D-3-dehydrosphinganine reductase activity" EXACT [EC:1.1.1.102]
synonym: "D-3-oxosphinganine reductase activity" EXACT [EC:1.1.1.102]
synonym: "D-3-oxosphinganine:B-NADPH oxidoreductase activity" EXACT [EC:1.1.1.102]
synonym: "D-erythro-dihydrosphingosine:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.102]
synonym: "DSR activity" EXACT [EC:1.1.1.102]
synonym: "KTS reductase activity" RELATED [EC:1.1.1.102]
xref: EC:1.1.1.102
xref: KEGG:R02978
xref: MetaCyc:3-DEHYDROSPHINGANINE-REDUCTASE-RXN
xref: Reactome:REACT_101332 "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+, Mus musculus"
xref: Reactome:REACT_104516 "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+, Sus scrofa"
xref: Reactome:REACT_104625 "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+, Dictyostelium discoideum"
xref: Reactome:REACT_105191 "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+, Taeniopygia guttata"
xref: Reactome:REACT_107834 "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+, Plasmodium falciparum"
xref: Reactome:REACT_108155 "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+, Oryza sativa"
xref: Reactome:REACT_110549 "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+, Canis familiaris"
xref: Reactome:REACT_116158 "3-dehydrosphinganine + NADPH + H+ => sphinganine + NADP+, Gallus gallus"
xref: Reactome:REACT_19162 "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+, Homo sapiens"
xref: Reactome:REACT_86270 "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+, Gallus gallus"
xref: Reactome:REACT_87447 "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+, Rattus norvegicus"
xref: Reactome:REACT_90694 "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+, Drosophila melanogaster"
xref: Reactome:REACT_93005 "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+, Arabidopsis thaliana"
xref: Reactome:REACT_93273 "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+, Xenopus tropicalis"
xref: Reactome:REACT_94440 "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+, Danio rerio"
xref: Reactome:REACT_97236 "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+, Bos taurus"
xref: RHEA:22643
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047561
name: 3-hydroxyanthranilate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxyanthranilate + O(2) = 6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H(2)O(2)." [EC:1.10.3.5, RHEA:17248]
synonym: "3-hydroxyanthranilate:oxygen oxidoreductase activity" EXACT [EC:1.10.3.5]
synonym: "3-hydroxyanthranilic acid oxidase activity" EXACT [EC:1.10.3.5]
xref: EC:1.10.3.5
xref: KEGG:R02666
xref: MetaCyc:3-HYDROXYANTHRANILATE-OXIDASE-RXN
xref: RHEA:17248
is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor

[Term]
id: GO:0047562
name: 3-hydroxyaspartate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3R)-3-hydroxy-L-aspartate = glycine + glyoxylate." [EC:4.1.3.14, RHEA:14380]
synonym: "erythro-3-hydroxy-L(s)-aspartate glyoxylate-lyase activity" EXACT [EC:4.1.3.14]
synonym: "erythro-3-hydroxy-Ls-aspartate glyoxylate-lyase (glycine-forming)" EXACT [EC:4.1.3.14]
synonym: "erythro-3-hydroxy-Ls-aspartate glyoxylate-lyase activity" EXACT [EC:4.1.3.14]
synonym: "erythro-beta-hydroxyaspartate aldolase activity" EXACT [EC:4.1.3.14]
synonym: "erythro-beta-hydroxyaspartate glycine-lyase activity" EXACT [EC:4.1.3.14]
xref: EC:4.1.3.14
xref: KEGG:R00478
xref: MetaCyc:3-HYDROXYASPARTATE-ALDOLASE-RXN
xref: RHEA:14380
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0047563
name: 3-hydroxybenzoate 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxybenzoate + AH(2) + O(2) = 2,3-dihydroxybenzoate + A + H(2)O." [EC:1.14.99.23, RHEA:14196]
synonym: "3-HBA-2-hydroxylase activity" EXACT [EC:1.14.99.23]
synonym: "3-hydroxybenzoate 2-hydroxylase activity" EXACT []
synonym: "3-hydroxybenzoate,hydrogen-donor:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.99.23]
xref: EC:1.14.99.23
xref: KEGG:R01508
xref: MetaCyc:3-HYDROXYBENZOATE-2-MONOOXYGENASE-RXN
xref: RHEA:14196
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0047564
name: 3-hydroxycyclohexanone dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxycyclohexanone + A = AH(2) + cyclohexane-1,3-dione." [EC:1.1.99.26, RHEA:15908]
synonym: "3-hydroxycyclohexanone:acceptor 1-oxidoreductase activity" EXACT [EC:1.1.99.26]
xref: EC:1.1.99.26
xref: KEGG:R03212
xref: MetaCyc:3-HYDROXYCYCLOHEXANONE-DEHYDROGENASE-RXN
xref: RHEA:15908
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0047565
name: 3-hydroxypropionate dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxypropanoate + NAD(+) = 3-oxopropanoate + H(+) + NADH." [EC:1.1.1.59, RHEA:13360]
synonym: "3-hydroxypropanoate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.59]
xref: EC:1.1.1.59
xref: KEGG:R01608
xref: MetaCyc:3-HYDROXYPROPIONATE-DEHYDROGENASE-RXN
xref: RHEA:13360
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047566
name: 3-ketovalidoxylamine C-N-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-nitrophenyl-3-ketovalidamine = 4-nitroaniline + 5-D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one + H(+)." [EC:4.3.3.1, RHEA:22771]
synonym: "3-ketovalidoxylamine A C-N-lyase activity" EXACT [EC:4.3.3.1]
synonym: "4-nitrophenyl-3-ketovalidamine 4-nitroaniline-lyase [5-D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one-forming]" RELATED [EC:4.3.3.1]
synonym: "4-nitrophenyl-3-ketovalidamine 4-nitroaniline-lyase activity" EXACT [EC:4.3.3.1]
synonym: "p-nitrophenyl-3-ketovalidamine p-nitroaniline lyase activity" EXACT [EC:4.3.3.1]
xref: EC:4.3.3.1
xref: KEGG:R04367
xref: MetaCyc:3-KETOVALIDOXYLAMINE-C-N-LYASE-RXN
xref: RHEA:22771
is_a: GO:0016843 ! amine-lyase activity

[Term]
id: GO:0047567
name: 3-methyleneoxindole reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-methyloxindole + NADP(+) = 3-methyleneoxindole + H(+) + NADPH." [EC:1.3.1.17, RHEA:20260]
synonym: "3-methyl-1,3-dihydroindol-2-one:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.17]
synonym: "3-methyloxindole:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.17]
xref: EC:1.3.1.17
xref: KEGG:R03930
xref: MetaCyc:3-METHYLENEOXINDOLE-REDUCTASE-RXN
xref: RHEA:20260
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047568
name: 3-oxo-5-beta-steroid 4-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 3-oxo-5-beta-steroid + acceptor = a 3-oxo-D4-steroid + reduced acceptor." [EC:1.3.99.6, MetaCyc:3-OXO-5-BETA-STEROID-4-DEHYDROGENASE-RXN]
synonym: "3-oxo-5beta-steroid 4-dehydrogenase activity" EXACT [EC:1.3.99.6]
synonym: "3-oxo-5beta-steroid:(acceptor) delta4-oxidoreductase activity" EXACT [EC:1.3.99.6]
synonym: "3-oxo-5beta-steroid:acceptor delta4-oxidoreductase activity" EXACT [EC:1.3.99.6]
synonym: "delta4-3-ketosteroid 5-beta-reductase activity" EXACT [EC:1.3.99.6]
xref: EC:1.3.99.6
xref: MetaCyc:3-OXO-5-BETA-STEROID-4-DEHYDROGENASE-RXN
is_a: GO:0033765 ! steroid dehydrogenase activity, acting on the CH-CH group of donors

[Term]
id: GO:0047569
name: 3-oxoadipate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: succinyl-CoA + 3-oxoadipate = succinate + 3-oxoadipyl-CoA." [EC:2.8.3.6, MetaCyc:3-OXOADIPATE-COA-TRANSFERASE-RXN]
subset: gosubset_prok
synonym: "3-oxoadipate coenzyme A-transferase activity" EXACT [EC:2.8.3.6]
synonym: "3-oxoadipate succinyl-CoA transferase activity" EXACT [EC:2.8.3.6]
synonym: "beta-ketoadipate:succinyl-CoA transferase activity" EXACT [EC:2.8.3.6]
synonym: "succinyl-CoA:3-oxoadipate CoA-transferase activity" EXACT [EC:2.8.3.6]
xref: EC:2.8.3.6
xref: MetaCyc:3-OXOADIPATE-COA-TRANSFERASE-RXN
xref: RHEA:12051
xref: UM-BBD_reactionID:r1050
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0047570
name: 3-oxoadipate enol-lactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-oxoadipate enol-lactone + H2O = 3-oxoadipate." [EC:3.1.1.24, MetaCyc:3-OXOADIPATE-ENOL-LACTONASE-RXN]
subset: gosubset_prok
synonym: "3-ketoadipate enol-lactonase activity" EXACT [EC:3.1.1.24]
synonym: "3-oxoadipic enol-lactone hydrolase activity" EXACT [EC:3.1.1.24]
synonym: "4-carboxymethylbut-3-en-4-olide enol-lactonohydrolase activity" EXACT [EC:3.1.1.24]
synonym: "beta-ketoadipate enol-lactone hydrolase activity" EXACT [EC:3.1.1.24]
synonym: "beta-ketoadipic enol-lactone hydrolase activity" EXACT [EC:3.1.1.24]
synonym: "carboxymethylbutenolide lactonase activity" EXACT [EC:3.1.1.24]
xref: EC:3.1.1.24
xref: MetaCyc:3-OXOADIPATE-ENOL-LACTONASE-RXN
xref: RHEA:10187
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0047571
name: 3-oxosteroid 1-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 3-oxosteroid + acceptor = a 3-oxo-D1-steroid + reduced acceptor." [EC:1.3.99.4, MetaCyc:3-OXOSTEROID-1-DEHYDROGENASE-RXN]
subset: gosubset_prok
synonym: "1-ene-dehydrogenase activity" EXACT [EC:1.3.99.4]
synonym: "3-ketosteroid-1-en-dehydrogenase activity" EXACT [EC:1.3.99.4]
synonym: "3-ketosteroid-delta1-dehydrogenase activity" EXACT [EC:1.3.99.4]
synonym: "3-oxosteroid delta1-dehydrogenase activity" EXACT [EC:1.3.99.4]
synonym: "3-oxosteroid:(2,6-dichlorphenolindophenol) delta1-oxidoreductase activity" EXACT [EC:1.3.99.4]
synonym: "3-oxosteroid:(acceptor) delta1-oxidoreductase activity" EXACT [EC:1.3.99.4]
synonym: "3-oxosteroid:acceptor delta1-oxidoreductase activity" EXACT [EC:1.3.99.4]
synonym: "4-en-3-oxosteroid:(acceptor)-1-en-oxido-reductase activity" EXACT [EC:1.3.99.4]
synonym: "delta1-dehydrogenase activity" EXACT [EC:1.3.99.4]
synonym: "delta1-steroid reductase activity" EXACT [EC:1.3.99.4]
xref: EC:1.3.99.4
xref: MetaCyc:3-OXOSTEROID-1-DEHYDROGENASE-RXN
xref: UM-BBD_enzymeID:e0712
is_a: GO:0033765 ! steroid dehydrogenase activity, acting on the CH-CH group of donors

[Term]
id: GO:0047572
name: 3-phosphoglycerate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-phospho-D-glycerate + H(2)O = D-glycerate + phosphate." [EC:3.1.3.38, RHEA:12415]
synonym: "3-PGA phosphatase activity" EXACT [EC:3.1.3.38]
synonym: "D-3-phosphoglycerate phosphatase activity" EXACT [EC:3.1.3.38]
synonym: "D-glycerate-3-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.38]
xref: EC:3.1.3.38
xref: KEGG:R01511
xref: MetaCyc:3-PHOSPHOGLYCERATE-PHOSPHATASE-RXN
xref: RHEA:12415
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0047573
name: 4-acetamidobutyrate deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-acetamidobutanoate + H2O = acetate + 4-aminobutanoate." [EC:3.5.1.63, MetaCyc:4-ACETAMIDOBUTYRATE-DEACETYLASE-RXN]
synonym: "4-acetamidobutanoate amidohydrolase activity" EXACT [EC:3.5.1.63]
xref: EC:3.5.1.63
xref: MetaCyc:4-ACETAMIDOBUTYRATE-DEACETYLASE-RXN
xref: RHEA:15900
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0019213 ! deacetylase activity

[Term]
id: GO:0047574
name: 4-acetamidobutyryl-CoA deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-acetamidobutanoyl-CoA + H(2)O = 4-aminobutanoyl-CoA + acetate." [EC:3.5.1.51, RHEA:22931]
synonym: "4-acetamidobutanoyl-CoA amidohydrolase activity" EXACT [EC:3.5.1.51]
synonym: "aminobutyryl-CoA thiolesterase activity" EXACT [EC:3.5.1.51]
synonym: "deacetylase-thiolesterase activity" EXACT [EC:3.5.1.51]
xref: EC:3.5.1.51
xref: KEGG:R04056
xref: MetaCyc:4-ACETAMIDOBUTYRYL-COA-DEACETYLASE-RXN
xref: RHEA:22931
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0019213 ! deacetylase activity

[Term]
id: GO:0047575
name: 4-carboxymuconolactone decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate + H(+) = 5-oxo-4,5-dihydro-2-furylacetate + CO(2)." [EC:4.1.1.44, RHEA:23351]
subset: gosubset_prok
synonym: "4-carboxymonolactone carboxy-lyase activity" EXACT [EC:4.1.1.44]
synonym: "4-carboxymuconolactone carboxy-lyase (4,5-dihydro-5-oxofuran-2-acetate-forming)" EXACT [EC:4.1.1.44]
synonym: "4-carboxymuconolactone carboxy-lyase activity" EXACT [EC:4.1.1.44]
synonym: "gamma-4-carboxymuconolactone decarboxylase activity" EXACT [EC:4.1.1.44]
xref: EC:4.1.1.44
xref: KEGG:R03470
xref: MetaCyc:4-CARBOXYMUCONOLACTONE-DECARBOXYLASE-RXN
xref: RHEA:23351
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047576
name: 4-chlorobenzoate dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-chlorobenzoate + H(2)O = 4-hydroxybenzoate + chloride + H(+)." [EC:3.8.1.6, RHEA:23443]
synonym: "4-chlorobenzoate chlorohydrolase activity" EXACT [EC:3.8.1.6]
synonym: "halobenzoate dehalogenase activity" EXACT [EC:3.8.1.6]
xref: EC:3.8.1.6
xref: KEGG:R01307
xref: MetaCyc:4-CHLOROBENZOATE-DEHALOGENASE-RXN
xref: RHEA:23443
is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds

[Term]
id: GO:0047577
name: 4-hydroxybutyrate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxybutanoate + NAD(+) = H(+) + NADH + succinate semialdehyde." [EC:1.1.1.61, RHEA:23951]
subset: gosubset_prok
synonym: "4-hydroxybutanoate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.61]
synonym: "gamma-hydroxybutyrate dehydrogenase activity" EXACT [EC:1.1.1.61]
xref: EC:1.1.1.61
xref: KEGG:R01644
xref: MetaCyc:4-HYDROXYBUTYRATE-DEHYDROGENASE-RXN
xref: RHEA:23951
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047578
name: 4-hydroxyglutamate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxy-L-glutamate + 2-oxoglutarate = 4-hydroxy-2-oxoglutarate + L-glutamate." [EC:2.6.1.23, MetaCyc:4-HYDROXYGLUTAMATE-AMINOTRANSFERASE-RXN]
synonym: "4-hydroxy-L-glutamate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.23]
synonym: "4-hydroxyglutamate aminotransferase activity" EXACT []
xref: EC:2.6.1.23
xref: MetaCyc:4-HYDROXYGLUTAMATE-AMINOTRANSFERASE-RXN
xref: RHEA:10483
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047579
name: 4-hydroxymandelate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-4-hydroxymandelate + H(+) + O(2) = 4-hydroxybenzaldehyde + CO(2) + H(2)O(2)." [EC:1.1.3.19, RHEA:15836]
synonym: "(S)-2-hydroxy-2-(4-hydroxyphenyl)acetate:oxygen 1-oxidoreductase activity" EXACT [EC:1.1.3.19]
synonym: "L-4-hydroxymandelate oxidase (decarboxylating)" EXACT [EC:1.1.3.19]
xref: EC:1.1.3.19
xref: KEGG:R02673
xref: MetaCyc:4-HYDROXYMANDELATE-OXIDASE-RXN
xref: RHEA:15836
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0047580
name: 4-hydroxyproline epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-4-hydroxy-L-proline = cis-4-hydroxy-D-proline." [EC:5.1.1.8, RHEA:21155]
synonym: "4-hydroxyproline 2-epimerase activity" EXACT [EC:5.1.1.8]
synonym: "hydroxyproline 2-epimerase activity" EXACT [EC:5.1.1.8]
synonym: "hydroxyproline epimerase activity" EXACT [EC:5.1.1.8]
synonym: "L-hydroxyproline epimerase activity" EXACT [EC:5.1.1.8]
xref: EC:5.1.1.8
xref: KEGG:R03296
xref: MetaCyc:4-HYDROXYPROLINE-EPIMERASE-RXN
xref: RHEA:21155
is_a: GO:0047661 ! amino-acid racemase activity

[Term]
id: GO:0047581
name: 4-methyleneglutamate-ammonia ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-methylene-L-glutamate + ATP + NH(4)(+) = 4-methylene-L-glutamine + AMP + diphosphate + 2 H(+)." [EC:6.3.1.7, RHEA:13856]
subset: gosubset_prok
synonym: "4-methylene-L-glutamate:ammonia ligase (AMP-forming)" EXACT [EC:6.3.1.7]
synonym: "4-methyleneglutamine synthetase activity" EXACT [EC:6.3.1.7]
xref: EC:6.3.1.7
xref: KEGG:R02711
xref: MetaCyc:4-METHYLENEGLUTAMATE--AMMONIA-LIGASE-RXN
xref: RHEA:13856
is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity

[Term]
id: GO:0047582
name: 4-methyleneglutaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-methylene-L-glutamine + H(2)O = 4-methylene-L-glutamate + NH(4)(+)." [EC:3.5.1.67, RHEA:14744]
synonym: "4-methylene-L-glutamine amidohydrolase activity" EXACT [EC:3.5.1.67]
synonym: "4-methyleneglutamine amidohydrolase activity" EXACT [EC:3.5.1.67]
synonym: "4-methyleneglutamine deamidase activity" EXACT [EC:3.5.1.67]
xref: EC:3.5.1.67
xref: KEGG:R02712
xref: MetaCyc:4-METHYLENEGLUTAMINASE-RXN
xref: RHEA:14744
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047583
name: 4-methyloxaloacetate esterase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-methoxy-2,4-dioxobutanoate + H(2)O = H(+) + methanol + oxaloacetate." [EC:3.1.1.44, RHEA:10567]
synonym: "oxaloacetate-4-methyl-ester oxaloacetohydrolase activity" EXACT [EC:3.1.1.44]
xref: EC:3.1.1.44
xref: KEGG:R01144
xref: MetaCyc:4-METHYLOXALOACETATE-ESTERASE-RXN
xref: RHEA:10567
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0047584
name: 4-oxalmesaconate hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate = (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + H(2)O." [EC:4.2.1.83, RHEA:17404]
subset: gosubset_prok
synonym: "2-hydroxy-4-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase [(E)-4-oxobut-1-ene-1,2,4-tricarboxylate-forming]" RELATED [EC:4.2.1.83]
synonym: "2-hydroxy-4-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase activity" EXACT [EC:4.2.1.83]
synonym: "4-carboxy-2-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase activity" EXACT [EC:4.2.1.83]
synonym: "4-carboxy-2-oxohexenedioate hydratase activity" EXACT [EC:4.2.1.83]
synonym: "gamma-oxalmesaconate hydratase activity" EXACT [EC:4.2.1.83]
synonym: "oxalmesaconate hydratase activity" EXACT [EC:4.2.1.83]
xref: EC:4.2.1.83
xref: KEGG:R04478
xref: MetaCyc:RXN-2463
xref: RHEA:17404
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047585
name: 4-pyridoxolactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-pyridoxolactone + H(2)O = 4-pyridoxate + H(+)." [EC:3.1.1.27, RHEA:14304]
synonym: "4-pyridoxolactone lactonohydrolase activity" EXACT [EC:3.1.1.27]
xref: EC:3.1.1.27
xref: KEGG:R02992
xref: MetaCyc:4-PYRIDOXOLACTONASE-RXN
xref: RHEA:14304
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0047586
name: 5'-acylphosphoadenosine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5'-acylphosphoadenosine + H2O = AMP + a carboxylate." [EC:3.6.1.20, MetaCyc:5-ACYLPHOSPHOADENOSINE-HYDROLASE-RXN]
synonym: "5'-acylphosphoadenosine acylhydrolase activity" EXACT [EC:3.6.1.20]
synonym: "5-phosphoadenosine hydrolase activity" EXACT [EC:3.6.1.20]
xref: EC:3.6.1.20
xref: MetaCyc:5-ACYLPHOSPHOADENOSINE-HYDROLASE-RXN
xref: RHEA:16840
is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

[Term]
id: GO:0047587
name: 5-alpha-hydroxysteroid dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5alpha-ergosta-7,22-diene-3beta,5-diol = ergosterol + H(2)O." [EC:4.2.1.62, RHEA:22067]
synonym: "5alpha-ergosta-7,22-diene-3beta,5-diol 5,6-hydro-lyase (ergosterol-forming)" EXACT [EC:4.2.1.62]
synonym: "5alpha-ergosta-7,22-diene-3beta,5-diol 5,6-hydro-lyase activity" EXACT [EC:4.2.1.62]
synonym: "5alpha-hydroxysteroid dehydratase activity" EXACT [EC:4.2.1.62]
xref: EC:4.2.1.62
xref: KEGG:R03675
xref: MetaCyc:5-ALPHA-HYDROXYSTEROID-DEHYDRATASE-RXN
xref: RHEA:22067
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047588
name: 5-aminopentanamidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-aminopentanamide + H2O = 5-aminopentanoate + NH3." [EC:3.5.1.30, MetaCyc:5-AMINOPENTANAMIDASE-RXN]
synonym: "5-aminonorvaleramidase activity" EXACT [EC:3.5.1.30]
synonym: "5-aminopentanamide amidohydrolase activity" EXACT [EC:3.5.1.30]
synonym: "5-aminovaleramidase activity" EXACT [EC:3.5.1.30]
xref: EC:3.5.1.30
xref: MetaCyc:5-AMINOPENTANAMIDASE-RXN
xref: RHEA:15680
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047589
name: 5-aminovalerate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + 5-aminopentanoate = 5-oxopentanoate + L-glutamate." [EC:2.6.1.48, RHEA:10215]
synonym: "5-aminopentanoate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.48]
synonym: "5-aminovalerate aminotransferase activity" EXACT []
synonym: "delta-aminovalerate aminotransferase activity" EXACT [EC:2.6.1.48]
synonym: "delta-aminovalerate transaminase activity" EXACT [EC:2.6.1.48]
xref: EC:2.6.1.48
xref: KEGG:R02274
xref: MetaCyc:VAGL-RXN
xref: RHEA:10215
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047590
name: 5-dehydro-2-deoxygluconokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 5-dehydro-2-deoxy-D-gluconate = ADP + 6-phospho-5-dehydro-2-deoxy-D-gluconate." [EC:2.7.1.92, MetaCyc:5-DEHYDRO-2-DEOXYGLUCONOKINASE-RXN]
subset: gosubset_prok
synonym: "5-keto-2-deoxyglucono kinase (phosphorylating)" EXACT [EC:2.7.1.92]
synonym: "5-keto-2-deoxygluconokinase activity" EXACT [EC:2.7.1.92]
synonym: "ATP:5-dehydro-2-deoxy-D-gluconate 6-phosphotransferase activity" EXACT [EC:2.7.1.92]
synonym: "DKH kinase activity" EXACT [EC:2.7.1.92]
xref: EC:2.7.1.92
xref: MetaCyc:5-DEHYDRO-2-DEOXYGLUCONOKINASE-RXN
xref: RHEA:13500
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047591
name: 5-hydroxypentanoate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-hydroxypentanoate + acetyl-CoA = 5-hydroxy-pentanoyl-CoA + acetate." [EC:2.8.3.14, RHEA:23499]
synonym: "5-hydroxyvalerate CoA-transferase activity" EXACT [EC:2.8.3.14]
synonym: "5-hydroxyvalerate coenzyme A transferase activity" EXACT [EC:2.8.3.14]
synonym: "acetyl-CoA:5-hydroxypentanoate CoA-transferase activity" EXACT [EC:2.8.3.14]
xref: EC:2.8.3.14
xref: KEGG:R04057
xref: MetaCyc:5-HYDROXYPENTANOATE-COA-TRANSFERASE-RXN
xref: RHEA:23499
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0047592
name: 5-pyridoxate dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-pyridoxate + NADPH + O(2) = (2Z)-2-(acetamidomethylene)-3-(hydroxymethyl)succinate + NADP(+)." [EC:1.14.12.5, RHEA:11155]
synonym: "5-pyridoxate oxidase activity" EXACT [EC:1.14.12.5]
synonym: "5-pyridoxate,NADPH:oxygen oxidoreductase (decyclizing)" EXACT [EC:1.14.12.5]
xref: EC:1.14.12.5
xref: KEGG:R04570
xref: MetaCyc:5-PYRIDOXATE-DIOXYGENASE-RXN
xref: RHEA:11155
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0047593
name: 6-acetylglucose deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-acetyl-D-glucose + H(2)O = D-glucose + acetate + H(+)." [EC:3.1.1.33, RHEA:18488]
synonym: "6-acetyl-D-glucose acetylhydrolase activity" EXACT [EC:3.1.1.33]
synonym: "6-O-acetylglucose deacetylase activity" EXACT [EC:3.1.1.33]
xref: EC:3.1.1.33
xref: KEGG:R00327
xref: MetaCyc:6-ACETYLGLUCOSE-DEACETYLASE-RXN
xref: RHEA:18488
is_a: GO:0019213 ! deacetylase activity
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0047594
name: 6-beta-hydroxyhyoscyamine epoxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: (6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O(2) = CO(2) + H(2)O + H(+) + scopolamine + succinate." [EC:1.14.11.14, RHEA:12800]
synonym: "(6S)-6-hydroxyhyoscyamine,2-oxoglutarate oxidoreductase (epoxide-forming)" EXACT [EC:1.14.11.14]
synonym: "6beta-hydroxyhyoscyamine epoxidase activity" EXACT [EC:1.14.11.14]
synonym: "hydroxyhyoscyamine dioxygenase activity" EXACT [EC:1.14.11.14]
xref: EC:1.14.11.14
xref: KEGG:R03737
xref: MetaCyc:6-BETA-HYDROXYHYOSCYAMINE-EPOXIDASE-RXN
xref: RHEA:12800
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0047595
name: 6-hydroxynicotinate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,4,5,6-tetrahydro-6-oxonicotinate + oxidized ferredoxin = 6-hydroxynicotinate + reduced ferredoxin." [EC:1.3.7.1, MetaCyc:6-HYDROXYNICOTINATE-REDUCTASE-RXN]
synonym: "1,4,5,6-tetrahydro-6-oxonicotinate:ferredoxin oxidoreductase activity" EXACT [EC:1.3.7.1]
synonym: "6-hydroxynicotinic reductase activity" EXACT [EC:1.3.7.1]
synonym: "6-oxo-1,4,5,6-tetrahydronicotinate:ferredoxin oxidoreductase activity" EXACT [EC:1.3.7.1]
synonym: "6-oxotetrahydro-nicotinate dehydrogenase activity" EXACT [EC:1.3.7.1]
synonym: "6-oxotetrahydronicotinate dehydrogenase activity" EXACT [EC:1.3.7.1]
synonym: "HNA reductase activity" EXACT [EC:1.3.7.1]
xref: EC:1.3.7.1
xref: MetaCyc:6-HYDROXYNICOTINATE-REDUCTASE-RXN
is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0047596
name: 6-methylsalicylate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-methylsalicylate + H(+) = 3-cresol + CO(2)." [EC:4.1.1.52, RHEA:23115]
synonym: "6-methylsalicylate carboxy-lyase (3-cresol-forming)" EXACT [EC:4.1.1.52]
synonym: "6-methylsalicylate carboxy-lyase activity" EXACT [EC:4.1.1.52]
synonym: "6-methylsalicylic acid (2,6-cresotic acid) decarboxylase activity" EXACT [EC:4.1.1.52]
synonym: "6-MSA decarboxylase activity" EXACT [EC:4.1.1.52]
xref: EC:4.1.1.52
xref: KEGG:R03567
xref: MetaCyc:6-METHYLSALICYLATE-DECARBOXYLASE-RXN
xref: RHEA:23115
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047597
name: 6-oxocineole dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-oxocineole + H(+) + NADPH + O(2) = 1,6,6-trimethyl-2,7-dioxabicyclo[3.2.2]nonan-3-one + H(2)O + NADP(+)." [EC:1.14.13.51, RHEA:24327]
synonym: "6-oxocineole oxygenase activity" EXACT [EC:1.14.13.51]
synonym: "6-oxocineole,NADPH:oxygen oxidoreductase activity" EXACT [EC:1.14.13.51]
xref: EC:1.14.13.51
xref: KEGG:R02995
xref: MetaCyc:6-OXOCINEOLE-DEHYDROGENASE-RXN
xref: RHEA:24327
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047598
name: 7-dehydrocholesterol reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: cholesterol + NADP+ = cholesta-5,7-dien-3-beta-ol + NADPH + H+." [EC:1.3.1.21]
synonym: "7-DHC reductase activity" EXACT [EC:1.3.1.21]
synonym: "cholesterol:NADP+ delta7-oxidoreductase activity" EXACT [EC:1.3.1.21]
synonym: "sterol Delta(7)-reductase activity" BROAD [EC:1.3.1.21]
synonym: "sterol delta7-reductase activity" EXACT [EC:1.3.1.21]
xref: EC:1.3.1.21
xref: MetaCyc:RXN66-323
xref: Reactome:REACT_10029 "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol, Homo sapiens"
xref: Reactome:REACT_102740 "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol, Bos taurus"
xref: Reactome:REACT_103448 "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol, Rattus norvegicus"
xref: Reactome:REACT_78943 "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol, Mus musculus"
xref: Reactome:REACT_79896 "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol, Taeniopygia guttata"
xref: Reactome:REACT_80775 "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol, Arabidopsis thaliana"
xref: Reactome:REACT_81232 "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol, Gallus gallus"
xref: Reactome:REACT_81435 "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol, Caenorhabditis elegans"
xref: Reactome:REACT_92821 "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol, Oryza sativa"
xref: Reactome:REACT_93761 "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol, Danio rerio"
xref: Reactome:REACT_96623 "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol, Canis familiaris"
xref: Reactome:REACT_98689 "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol, Xenopus tropicalis"
xref: RHEA:23987
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047599
name: 8-oxocoformycin reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: coformycin + NADP(+) = 8-oxocoformycin + 2 H(+) + NADPH." [EC:1.1.1.235, RHEA:23171]
synonym: "8-ketodeoxycoformycin reductase activity" EXACT [EC:1.1.1.235]
synonym: "coformycin:NADP+ 8-oxidoreductase activity" EXACT [EC:1.1.1.235]
xref: EC:1.1.1.235
xref: KEGG:R03667
xref: MetaCyc:8-OXOCOFORMYCIN-REDUCTASE-RXN
xref: RHEA:23171
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047600
name: abequosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CDP-abequose + D-mannosyl-L-rhamnosyl-D-galactose-1-diphospholipid = CDP + D-abequosyl-D-mannosyl-rhamnosyl-D-galactose-1-diphospholipid." [EC:2.4.1.60, MetaCyc:ABEQUOSYLTRANSFERASE-RXN]
synonym: "CDP-abequose:D-mannosyl-L-rhamnosyl-D-galactose-1-diphospholipid D-abequosyltransferase activity" EXACT [EC:2.4.1.60]
synonym: "trihexose diphospholipid abequosyltransferase activity" EXACT [EC:2.4.1.60]
xref: EC:2.4.1.60
xref: MetaCyc:ABEQUOSYLTRANSFERASE-RXN
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0047601
name: acetate kinase (diphosphate) activity
namespace: molecular_function
def: "Catalysis of the reaction: acetate + diphosphate = acetyl phosphate + phosphate." [EC:2.7.2.12, RHEA:24279]
synonym: "acetate kinase (pyrophosphate) activity" EXACT [EC:2.7.2.12]
synonym: "diphosphate:acetate phosphotransferase activity" EXACT [EC:2.7.2.12]
synonym: "pyrophosphate-acetate phosphotransferase activity" EXACT [EC:2.7.2.12]
xref: EC:2.7.2.12
xref: KEGG:R00320
xref: MetaCyc:ACETATE-KINASE-PYROPHOSPHATE-RXN
xref: RHEA:24279
is_a: GO:0016301 ! kinase activity
is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor

[Term]
id: GO:0047602
name: acetoacetate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetoacetate + H(+) = acetone + CO(2)." [EC:4.1.1.4, RHEA:19732]
subset: gosubset_prok
synonym: "acetoacetate carboxy-lyase (acetone-forming)" EXACT [EC:4.1.1.4]
synonym: "acetoacetate carboxy-lyase activity" EXACT [EC:4.1.1.4]
synonym: "acetoacetic acid decarboxylase activity" EXACT [EC:4.1.1.4]
xref: EC:4.1.1.4
xref: KEGG:R01366
xref: MetaCyc:ACETOACETATE-DECARBOXYLASE-RXN
xref: RHEA:19732
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047603
name: acetoacetyl-CoA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetoacetyl-CoA + H(2)O = acetoacetate + CoA + H(+)." [EC:3.1.2.11, RHEA:15676]
synonym: "acetoacetyl CoA deacylase activity" EXACT [EC:3.1.2.11]
synonym: "acetoacetyl coenzyme A deacylase activity" EXACT [EC:3.1.2.11]
synonym: "acetoacetyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.11]
xref: EC:3.1.2.11
xref: KEGG:R01358
xref: MetaCyc:ACETOACETYL-COA-HYDROLASE-RXN
xref: RHEA:15676
is_a: GO:0016289 ! CoA hydrolase activity

[Term]
id: GO:0047604
name: acetoin racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-acetoin = (R)-acetoin." [EC:5.1.2.4, RHEA:12095]
synonym: "acetylmethylcarbinol racemase activity" EXACT [EC:5.1.2.4]
xref: EC:5.1.2.4
xref: KEGG:R02949
xref: MetaCyc:ACETOIN-RACEMASE-RXN
xref: RHEA:12095
is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives

[Term]
id: GO:0047605
name: acetolactate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-2-hydroxy-2-methyl-3-oxobutanoate = (R)-2-acetoin + CO2." [EC:4.1.1.5, MetaCyc:ACETOLACTATE-DECARBOXYLASE-RXN]
subset: gosubset_prok
synonym: "(S)-2-hydroxy-2-methyl-3-oxobutanoate carboxy-lyase [(R)-2-acetoin-forming]" RELATED [EC:4.1.1.5]
synonym: "(S)-2-hydroxy-2-methyl-3-oxobutanoate carboxy-lyase activity" EXACT [EC:4.1.1.5]
synonym: "alpha-acetolactate decarboxylase activity" EXACT [EC:4.1.1.5]
xref: EC:4.1.1.5
xref: MetaCyc:ACETOLACTATE-DECARBOXYLASE-RXN
xref: RHEA:21583
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047606
name: hydroxynitrilase activity
namespace: molecular_function
alt_id: GO:0046991
def: "Catalysis of the reaction: a hydroxynitrile = cyanide + an aldehyde or ketone." [EC:4.1.2, GOC:mah, MetaCyc:ACETONE-CYANHYDRIN-LYASE-RXN]
comment: This term represents a deleted EC activity and is scheduled for obsoletion.
subset: mf_needs_review
synonym: "(S)-acetone-cyanohydrin lyase activity" NARROW [EC:4.1.2.37]
synonym: "2-hydroxyisobutyronitrile acetone-lyase (cyanide-forming)" NARROW [EC:4.1.2.37]
synonym: "2-hydroxyisobutyronitrile acetone-lyase activity" NARROW [EC:4.1.2.37]
synonym: "acetone-cyanhydrin lyase activity" NARROW [EC:4.1.2.37]
synonym: "acetone-cyanohydrin acetone-lyase (cyanide-forming)" NARROW [EC:4.1.2.37]
synonym: "acetone-cyanohydrin acetone-lyase activity" NARROW [EC:4.1.2.37]
synonym: "acetone-cyanohydrin lyase activity" NARROW [EC:4..1.2.37]
synonym: "alpha-hydroxynitrile lyase activity" NARROW [EC:4.1.2.37]
synonym: "hydroxynitrile lyase activity" EXACT [GOC:curators]
synonym: "oxynitrilase activity" RELATED [EC:4.1.2.37]
xref: EC:4.1.2.37
xref: MetaCyc:4.1.2.39-RXN
xref: MetaCyc:ACETONE-CYANHYDRIN-LYASE-RXN
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0047608
name: acetylindoxyl oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetylindoxyl + O2 = N-acetylisatin + unknown." [EC:1.7.3.2, MetaCyc:ACETYLINDOXYL-OXIDASE-RXN]
synonym: "N-acetylindoxyl:oxygen oxidoreductase activity" EXACT [EC:1.7.3.2]
xref: EC:1.7.3.2
xref: MetaCyc:ACETYLINDOXYL-OXIDASE-RXN
xref: RHEA:16944
is_a: GO:0016663 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor

[Term]
id: GO:0047609
name: acetylputrescine deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetylputrescine + H(2)O = acetate + putrescine." [EC:3.5.1.62, RHEA:23415]
synonym: "N-acetylputrescine acetylhydrolase activity" EXACT [EC:3.5.1.62]
xref: EC:3.5.1.62
xref: KEGG:R01156
xref: MetaCyc:ACETYLPUTRESCINE-DEACETYLASE-RXN
xref: RHEA:23415
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0019213 ! deacetylase activity

[Term]
id: GO:0047610
name: acetylsalicylate deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetylsalicylate + H(2)O = acetate + H(+) + salicylate." [EC:3.1.1.55, RHEA:11755]
synonym: "acetylsalicylate O-acetylhydrolase activity" EXACT [EC:3.1.1.55]
synonym: "acetylsalicylic acid esterase activity" EXACT [EC:3.1.1.55]
synonym: "aspirin esterase activity" EXACT [EC:3.1.1.55]
synonym: "aspirin hydrolase activity" EXACT [EC:3.1.1.55]
xref: EC:3.1.1.55
xref: KEGG:R02942
xref: MetaCyc:ACETYLSALICYLATE-DEACETYLASE-RXN
xref: RHEA:11755
is_a: GO:0019213 ! deacetylase activity
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0047611
name: acetylspermidine deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N(8)-acetylspermidine + H(2)O = acetate + spermidine." [EC:3.5.1.48, RHEA:23931]
subset: gosubset_prok
synonym: "8-N-acetylspermidine amidohydrolase activity" EXACT [EC:3.5.1.48]
synonym: "N(1)-acetylspermidine amidohydrolase activity" EXACT [EC:3.5.1.48]
synonym: "N(8)-acetylspermidine amidohydrolase activity" RELATED [EC:3.5.1.48]
synonym: "N(8)-acetylspermidine deacetylase activity" RELATED [EC:3.5.1.48]
synonym: "N(8)-monoacetylspermidine deacetylase activity" RELATED [EC:3.5.1.48]
synonym: "N-acetylspermidine deacetylase activity" BROAD [EC:3.5.1.48]
synonym: "N1-acetylspermidine amidohydrolase activity" EXACT [EC:3.5.1.48]
synonym: "N8-acetylspermidine amidohydrolase activity" EXACT [EC:3.5.1.48]
synonym: "N8-acetylspermidine deacetylase activity" EXACT [EC:3.5.1.48]
synonym: "N8-monoacetylspermidine deacetylase activity" EXACT [EC:3.5.1.48]
xref: EC:3.5.1.48
xref: KEGG:R07300
xref: MetaCyc:ACETYLSPERMIDINE-DEACETYLASE-RXN
xref: RHEA:23931
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0019213 ! deacetylase activity

[Term]
id: GO:0047612
name: acid-CoA ligase (GDP-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: a carboxylate + CoA + GTP = acyl-CoA + GDP + H(+) + phosphate." [EC:6.2.1.10, RHEA:10971]
synonym: "acid:CoA ligase (GDP-forming)" EXACT [EC:6.2.1.10]
synonym: "acyl coenzyme A synthetase (guanosine diphosphate forming)" EXACT [EC:6.2.1.10]
synonym: "acyl-CoA synthetase (GDP-forming) activity" EXACT [EC:6.2.1.10]
xref: EC:6.2.1.10
xref: KEGG:R00394
xref: MetaCyc:ACID--COA-LIGASE-GDP-FORMING-RXN
xref: RHEA:10971
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0047613
name: aconitate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-aconitate + H(+) = CO(2) + itaconate." [EC:4.1.1.6, RHEA:15256]
synonym: "CAD activity" BROAD [EC:4.1.1.6]
synonym: "cis-aconitate carboxy-lyase (itaconate-forming)" EXACT [EC:4.1.1.6]
synonym: "cis-aconitate carboxy-lyase activity" EXACT [EC:4.1.1.6]
synonym: "cis-aconitic decarboxylase activity" EXACT [EC:4.1.1.6]
xref: EC:4.1.1.6
xref: KEGG:R02243
xref: MetaCyc:ACONITATE-DECARBOXYLASE-RXN
xref: RHEA:15256
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047614
name: aconitate delta-isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-aconitate = cis-aconitate." [EC:5.3.3.7, RHEA:17268]
synonym: "aconitate D-isomerase activity" EXACT []
synonym: "aconitate delta2-delta3-isomerase activity" EXACT [EC:5.3.3.7]
synonym: "aconitate isomerase activity" BROAD [EC:5.3.3.7]
xref: EC:5.3.3.7
xref: KEGG:R02244
xref: MetaCyc:ACONITATE-DELTA-ISOMERASE-RXN
xref: RHEA:17268
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0047615
name: actinomycin lactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: actinomycin + H2O = actinomycinic monolactone." [EC:3.1.1.39, MetaCyc:ACTINOMYCIN-LACTONASE-RXN]
synonym: "actinomycin lactonohydrolase activity" EXACT [EC:3.1.1.39]
xref: EC:3.1.1.39
xref: MetaCyc:ACTINOMYCIN-LACTONASE-RXN
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0047616
name: acyl-CoA dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + NADP+ = 2,3-dehydroacyl-CoA + NADPH + H+." [EC:1.3.1.8, MetaCyc:ACYL-COA-DEHYDROGENASE-NADP+-RXN]
synonym: "2-enoyl-CoA reductase activity" EXACT [EC:1.3.1.8]
synonym: "acyl-CoA:NADP+ 2-oxidoreductase activity" EXACT [EC:1.3.1.8]
synonym: "crotonyl coenzyme A reductase activity" EXACT [EC:1.3.1.8]
synonym: "dehydrogenase, acyl coenzyme A (nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.3.1.8]
synonym: "enoyl coenzyme A reductase activity" EXACT [EC:1.3.1.8]
xref: EC:1.3.1.8
xref: MetaCyc:ACYL-COA-DEHYDROGENASE-NADP+-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047617
name: acyl-CoA hydrolase activity
namespace: molecular_function
alt_id: GO:0008778
alt_id: GO:0016291
alt_id: GO:0016292
def: "Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate." [EC:3.1.2.20, MetaCyc:ACYL-COA-HYDROLASE-RXN]
subset: gosubset_prok
synonym: "acyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.20]
synonym: "acyl coenzyme A thioesterase activity" EXACT [EC:3.1.2.20]
synonym: "acyl-CoA thioesterase activity" EXACT []
synonym: "acyl-CoA thioesterase I activity" NARROW []
synonym: "acyl-CoA thioesterase II activity" NARROW []
synonym: "acyl-CoA thiolesterase activity" EXACT []
synonym: "thioesterase B" RELATED [EC:3.1.2.20]
synonym: "thioesterase II" RELATED [EC:3.1.2.20]
xref: EC:3.1.2.-
xref: EC:3.1.2.20
xref: MetaCyc:ACYL-COA-HYDROLASE-RXN
xref: RHEA:16784
is_a: GO:0016289 ! CoA hydrolase activity

[Term]
id: GO:0047618
name: acylagmatine amidase activity
namespace: molecular_function
def: "Catalysis of the reaction: N(4)-benzoylagmatine + H(2)O = agmatine + benzoate." [EC:3.5.1.40, RHEA:15068]
synonym: "acylagmatine amidohydrolase activity" EXACT [EC:3.5.1.40]
synonym: "acylagmatine deacylase activity" EXACT [EC:3.5.1.40]
synonym: "benzoylagmatine amidohydrolase activity" EXACT [EC:3.5.1.40]
xref: EC:3.5.1.40
xref: KEGG:R01425
xref: MetaCyc:ACYLAGMATINE-AMIDASE-RXN
xref: RHEA:15068
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047619
name: acylcarnitine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: O-acylcarnitine + H2O = a fatty acid + L-carnitine." [EC:3.1.1.28, MetaCyc:ACYLCARNITINE-HYDROLASE-RXN]
synonym: "carnitine ester hydrolase activity" EXACT [EC:3.1.1.28]
synonym: "HACH" RELATED [EC:3.1.1.28]
synonym: "high activity acylcarnitine hydrolase activity" EXACT [EC:3.1.1.28]
synonym: "long-chain acyl-L-carnitine hydrolase activity" EXACT [EC:3.1.1.28]
synonym: "O-acylcarnitine acylhydrolase activity" EXACT [EC:3.1.1.28]
synonym: "palmitoyl carnitine hydrolase activity" EXACT [EC:3.1.1.28]
synonym: "palmitoyl-L-carnitine hydrolase activity" EXACT [EC:3.1.1.28]
synonym: "palmitoylcarnitine hydrolase activity" EXACT [EC:3.1.1.28]
xref: EC:3.1.1.28
xref: MetaCyc:ACYLCARNITINE-HYDROLASE-RXN
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0047620
name: acylglycerol kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + acylglycerol = ADP + acyl-sn-glycerol 3-phosphate." [EC:2.7.1.94, MetaCyc:ACYLGLYCEROL-KINASE-RXN]
synonym: "ATP:acylglycerol 3-phosphotransferase activity" EXACT [EC:2.7.1.94]
synonym: "MGK" RELATED [EC:2.7.1.94]
synonym: "monoacylglycerol kinase (phosphorylating)" EXACT [EC:2.7.1.94]
synonym: "monoacylglycerol kinase activity" EXACT [EC:2.7.1.94]
synonym: "monoglyceride kinase activity" EXACT [EC:2.7.1.94]
synonym: "monoglyceride phosphokinase activity" EXACT [EC:2.7.1.94]
synonym: "sn-2-monoacylglycerol kinase activity" EXACT [EC:2.7.1.94]
xref: EC:2.7.1.94
xref: MetaCyc:ACYLGLYCEROL-KINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047621
name: acylpyruvate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 3-acylpyruvate + H2O = a carboxylate + pyruvate." [EC:3.7.1.5, MetaCyc:ACYLPYRUVATE-HYDROLASE-RXN]
subset: gosubset_prok
synonym: "3-acylpyruvate acylhydrolase activity" EXACT [EC:3.7.1.5]
xref: EC:3.7.1.5
xref: MetaCyc:ACYLPYRUVATE-HYDROLASE-RXN
xref: UM-BBD_reactionID:r1401
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0047622
name: adenosine nucleosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: adenosine + H2O = D-ribose + adenine." [EC:3.2.2.7, MetaCyc:ADENOSINE-NUCLEOSIDASE-RXN]
synonym: "adenosinase activity" EXACT [EC:3.2.2.7]
synonym: "adenosine hydrolase activity" EXACT [EC:3.2.2.7]
synonym: "adenosine ribohydrolase activity" EXACT [EC:3.2.2.7]
synonym: "ANase activity" EXACT [EC:3.2.2.7]
synonym: "N-ribosyladenine ribohydrolase activity" EXACT [EC:3.2.2.7]
xref: EC:3.2.2.7
xref: MetaCyc:ADENOSINE-NUCLEOSIDASE-RXN
xref: RHEA:18672
is_a: GO:0008477 ! purine nucleosidase activity

[Term]
id: GO:0047623
name: adenosine-phosphate deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: an adenosine-phosphate + H20 = an inosine phosphate + NH3. Catalyzes the deamination of AMP, ADP or ATP." [EC:3.5.4.17, GOC:bf, MetaCyc:ADENOSINE-PHOSPHATE-DEAMINASE-RXN]
comment: Consider instead annotating to one of the more specific terms: AMP deaminase activity ; GO:0003876, ADP deaminase activity ; GO:0047629, or ATP deaminase activity ; GO:0047692.
synonym: "adenine nucleotide deaminase activity" EXACT [EC:3.5.4.17]
synonym: "adenosine (phosphate) deaminase activity" EXACT [EC:3.5.4.17]
synonym: "adenosine-phosphate aminohydrolase activity" EXACT [EC:3.5.4.17]
xref: EC:3.5.4.17
xref: MetaCyc:ADENOSINE-PHOSPHATE-DEAMINASE-RXN
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0047624
name: adenosine-tetraphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: adenosine 5'-tetraphosphate + H2O = ATP + phosphate." [EC:3.6.1.14, MetaCyc:ADENOSINE-TETRAPHOSPHATASE-RXN]
subset: gosubset_prok
synonym: "adenosine-tetraphosphate phosphohydrolase activity" EXACT [EC:3.6.1.14]
xref: EC:3.6.1.14
xref: MetaCyc:ADENOSINE-TETRAPHOSPHATASE-RXN
xref: RHEA:24503
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0047625
name: adenosylmethionine cyclotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) = S-methyl-5'-thioadenosine + homoserine lactone." [EC:2.5.1.4, RHEA:21935]
synonym: "adenosyl methionine cyclotransferase activity" EXACT []
synonym: "adenosylmethioninase activity" EXACT [EC:2.5.1.4]
synonym: "S-adenosyl-L-methionine alkyltransferase (cyclizing)" EXACT [EC:2.5.1.4]
xref: EC:2.5.1.4
xref: KEGG:R00180
xref: MetaCyc:ADENOSYLMETHIONINE-CYCLOTRANSFERASE-RXN
xref: RHEA:21935
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0047626
name: adenosylmethionine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + H(2)O = S-methyl-5'-thioadenosine + L-homoserine + H(+)." [EC:3.3.1.2, RHEA:14648]
synonym: "adenosyl methionine hydrolase activity" EXACT []
synonym: "adenosylmethionine lyase activity" EXACT [EC:3.3.1.2]
synonym: "methylmethionine-sulfonium-salt hydrolase activity" EXACT [EC:3.3.1.2]
synonym: "S-adenosyl-L-methionine hydrolase activity" EXACT [EC:3.3.1.2]
synonym: "S-adenosylmethionine cleaving enzyme activity" EXACT [EC:3.3.1.2]
xref: EC:3.3.1.2
xref: KEGG:R00175
xref: MetaCyc:ADENOSYLMETHIONINE-HYDROLASE-RXN
xref: RHEA:14648
is_a: GO:0016802 ! trialkylsulfonium hydrolase activity

[Term]
id: GO:0047627
name: adenylylsulfatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5'-adenylyl sulfate + H(2)O = AMP + 2 H(+) + sulfate." [EC:3.6.2.1, RHEA:17044]
synonym: "adenosine 5-phosphosulfate sulfohydrolase activity" EXACT [EC:3.6.2.1]
synonym: "adenylylsulfate sulfohydrolase activity" EXACT [EC:3.6.2.1]
synonym: "adenylylsulphatase activity" EXACT []
xref: EC:3.6.2.1
xref: KEGG:R00531
xref: MetaCyc:ADENYLYLSULFATASE-RXN
xref: RHEA:17044
is_a: GO:0016819 ! hydrolase activity, acting on acid anhydrides, in sulfonyl-containing anhydrides

[Term]
id: GO:0047628
name: ADP-thymidine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ADP + thymidine = AMP + thymidine 5'-phosphate." [EC:2.7.1.118, MetaCyc:ADP--THYMIDINE-KINASE-RXN]
synonym: "adenosine diphosphate-thymidine phosphotransferase activity" EXACT [EC:2.7.1.118]
synonym: "ADP:dThd phosphotransferase activity" EXACT [EC:2.7.1.118]
synonym: "ADP:thymidine 5'-phosphotransferase activity" EXACT [EC:2.7.1.118]
xref: EC:2.7.1.118
xref: MetaCyc:ADP--THYMIDINE-KINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047629
name: ADP deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: ADP + H2O = IDP + NH3." [EC:3.5.4.7, MetaCyc:ADP-DEAMINASE-RXN]
synonym: "adenosine diphosphate deaminase activity" EXACT [EC:3.5.4.7]
synonym: "adenosinepyrophosphate deaminase activity" EXACT [EC:3.5.4.7]
synonym: "ADP aminohydrolase activity" EXACT [EC:3.5.4.7]
xref: EC:3.5.4.7
xref: MetaCyc:ADP-DEAMINASE-RXN
xref: RHEA:12744
is_a: GO:0047623 ! adenosine-phosphate deaminase activity

[Term]
id: GO:0047630
name: ADP-phosphoglycerate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-ADP-2-phosphoglycerate + H(2)O = 3-ADP-glycerate + phosphate." [EC:3.1.3.28, RHEA:15864]
synonym: "3-(ADP)-2-phosphoglycerate phosphohydrolase activity" EXACT [EC:3.1.3.28]
synonym: "adenosine diphosphate phosphoglycerate phosphatase activity" EXACT [EC:3.1.3.28]
synonym: "ADPphosphoglycerate phosphatase activity" EXACT [EC:3.1.3.28]
xref: EC:3.1.3.28
xref: KEGG:R03969
xref: MetaCyc:ADP-PHOSPHOGLYCERATE-PHOSPHATASE-RXN
xref: RHEA:15864
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0047631
name: ADP-ribose diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: ADP-ribose + H2O = AMP + D-ribose 5-phosphate." [EC:3.6.1.13, MetaCyc:ADP-RIBOSE-PYROPHOSPHATASE-RXN]
subset: gosubset_prok
synonym: "adenosine diphosphoribose pyrophosphatase activity" EXACT []
synonym: "ADP-ribose phosphohydrolase activity" EXACT []
synonym: "ADP-ribose pyrophosphatase activity" EXACT []
synonym: "ADP-ribose ribophosphohydrolase activity" EXACT [EC:3.6.1.13]
synonym: "ADPR-PPase activity" EXACT []
synonym: "ADPribose diphosphatase activity" EXACT [EC:3.6.1.13]
synonym: "ADPribose pyrophosphatase activity" EXACT [EC:3.6.1.13]
xref: EC:3.6.1.13
xref: MetaCyc:RXN0-1441
xref: RHEA:10415
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0047632
name: agmatine deiminase activity
namespace: molecular_function
def: "Catalysis of the reaction: agmatine + H2O = N-carbamoylputrescine + NH3." [EC:3.5.3.12, MetaCyc:AGMATINE-DEIMINASE-RXN]
subset: gosubset_prok
synonym: "agmatine amidinohydrolase" BROAD [EC:3.5.3.12]
synonym: "agmatine iminohydrolase activity" EXACT [EC:3.5.3.12]
xref: EC:3.5.3.12
xref: MetaCyc:AGMATINE-DEIMINASE-RXN
xref: RHEA:18040
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0047633
name: agmatine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: agmatine + ATP = N(4)-phosphoagmatine + ADP + 3 H(+)." [EC:2.7.3.10, RHEA:15956]
synonym: "ATP:agmatine 4-N-phosphotransferase activity" EXACT [EC:2.7.3.10]
synonym: "ATP:agmatine N4-phosphotransferase activity" EXACT [EC:2.7.3.10]
synonym: "phosphagen phosphokinase activity" RELATED [EC:2.7.3.10]
xref: EC:2.7.3.10
xref: KEGG:R01417
xref: MetaCyc:AGMATINE-KINASE-RXN
xref: RHEA:15956
is_a: GO:0016301 ! kinase activity
is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor

[Term]
id: GO:0047634
name: agmatine N4-coumaroyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-coumaroyl-CoA + agmatine = N-(4-guanidiniumylbutyl)-4-hydroxycinnamamide + CoA + H(+)." [EC:2.3.1.64, RHEA:13408]
synonym: "4-coumaroyl-CoA:agmatine 4-N-coumaroyltransferase activity" EXACT [EC:2.3.1.64]
synonym: "4-coumaroyl-CoA:agmatine N4-coumaroyltransferase activity" EXACT [EC:2.3.1.64]
synonym: "agmatine coumaroyltransferase activity" EXACT [EC:2.3.1.64]
synonym: "p-coumaroyl-CoA-agmatine N-p-coumaroyltransferase activity" EXACT [EC:2.3.1.64]
xref: EC:2.3.1.64
xref: KEGG:R01617
xref: MetaCyc:AGMATINE-N4-COUMAROYLTRANSFERASE-RXN
xref: RHEA:13408
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0047635
name: alanine-oxo-acid transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-alanine + a 2-oxo acid = pyruvate + an L-amino acid." [EC:2.6.1.12, MetaCyc:ALANINE--OXO-ACID-AMINOTRANSFERASE-RXN]
subset: gosubset_prok
synonym: "alanine--oxo-acid aminotransferase activity" EXACT [EC:2.6.1.12]
synonym: "alanine-keto acid aminotransferase activity" EXACT [EC:2.6.1.12]
synonym: "alanine-oxo acid aminotransferase activity" EXACT [EC:2.6.1.12]
synonym: "alanine-oxo-acid aminotransferase activity" EXACT []
synonym: "L-alanine-alpha-keto acid aminotransferase activity" EXACT [EC:2.6.1.12]
synonym: "L-alanine:2-oxo-acid aminotransferase activity" EXACT [EC:2.6.1.12]
synonym: "leucine-alanine transaminase activity" EXACT [EC:2.6.1.12]
xref: EC:2.6.1.12
xref: MetaCyc:ALANINE--OXO-ACID-AMINOTRANSFERASE-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047636
name: alanopine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,2'-iminodipropanoate + H(2)O + NAD(+) = L-alanine + H(+) + NADH + pyruvate." [EC:1.5.1.17, RHEA:17592]
synonym: "2,2'-iminodipropanoate:NAD+ oxidoreductase (L-alanine-forming)" EXACT [EC:1.5.1.17]
synonym: "ADH" RELATED [EC:1.5.1.17]
synonym: "alanopine: NAD oxidoreductase activity" EXACT [EC:1.5.1.17]
synonym: "alanopine:NAD oxidoreductase activity" EXACT [EC:1.5.1.17]
synonym: "alanopine[meso-N-(1-carboxyethyl)-alanine]dehydrogenase activity" EXACT [EC:1.5.1.17]
synonym: "ALPDH" RELATED [EC:1.5.1.17]
synonym: "meso-N-(1-carboxyethyl)-alanine:NAD+ oxidoreductase activity" EXACT [EC:1.5.1.17]
xref: EC:1.5.1.17
xref: KEGG:R00398
xref: MetaCyc:ALANOPINE-DEHYDROGENASE-RXN
xref: RHEA:17592
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047637
name: alanylphosphatidylglycerol synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-alanyl-tRNA + phosphatidylglycerol = tRNA + 3-O-L-alanyl-1-O-phosphatidylglycerol." [EC:2.3.2.11, MetaCyc:ALANYLPHOSPHATIDYLGLYCEROL-SYNTHASE-RXN]
synonym: "alanyl phosphatidylglycerol synthetase activity" EXACT [EC:2.3.2.11]
synonym: "L-alanyl-tRNA:phosphatidylglycerol alanyltransferase activity" EXACT [EC:2.3.2.11]
synonym: "O-alanylphosphatidylglycerol synthase activity" EXACT [EC:2.3.2.11]
xref: EC:2.3.2.11
xref: MetaCyc:ALANYLPHOSPHATIDYLGLYCEROL-SYNTHASE-RXN
is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups

[Term]
id: GO:0047638
name: albendazole monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: albendazole + H(+) + NADPH + O(2) = albendazole S-oxide + H(2)O + NADP(+)." [EC:1.14.13.32, RHEA:10799]
synonym: "albendazole oxidase activity" EXACT [EC:1.14.13.32]
synonym: "albendazole sulfoxidase activity" EXACT [EC:1.14.13.32]
synonym: "albendazole,NADPH:oxygen oxidoreductase (sulfoxide-forming)" EXACT [EC:1.14.13.32]
xref: EC:1.14.13.32
xref: KEGG:R03712
xref: MetaCyc:ALBENDAZOLE-MONOOXYGENASE-RXN
xref: RHEA:10799
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047639
name: alcohol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a primary alcohol + O2 = an aldehyde + H2O2." [EC:1.1.3.13, MetaCyc:ALCOHOL-OXIDASE-RXN]
comment: Note that the enzyme alcohol oxidase also has methanol oxidase activity (GO:0046563).
synonym: "alcohol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.13]
synonym: "AOX activity" EXACT [EC:1.1.3.13]
synonym: "ethanol oxidase activity" EXACT [EC:1.1.3.13]
xref: EC:1.1.3.13
xref: MetaCyc:ALCOHOL-OXIDASE-RXN
xref: RHEA:19832
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0047640
name: aldose 1-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-aldose + NAD+ = D-aldonolactone + NADH." [EC:1.1.1.121, MetaCyc:ALDOSE-1-DEHYDROGENASE-RXN]
synonym: "aldose dehydrogenase activity" EXACT [EC:1.1.1.121]
synonym: "D-aldose:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.121]
synonym: "dehydrogenase, D-aldohexose" EXACT [EC:1.1.1.121]
xref: EC:1.1.1.121
xref: MetaCyc:ALDOSE-1-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047641
name: aldose-6-phosphate reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucitol 6-phosphate + NADP(+) = D-glucose 6-phosphate + H(+) + NADPH." [EC:1.1.1.200, RHEA:20040]
synonym: "A6PR" RELATED [EC:1.1.1.200]
synonym: "alditol 6-phosphate:NADP 1-oxidoreductase activity" EXACT [EC:1.1.1.200]
synonym: "aldose 6-phosphate reductase activity" EXACT [EC:1.1.1.200]
synonym: "aldose-6-P reductase activity" EXACT [EC:1.1.1.200]
synonym: "aldose-6-phosphate reductase activity" EXACT [EC:1.1.1.200]
synonym: "D-aldose-6-phosphate:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.200]
synonym: "NADP-dependent aldose 6-phosphate reductase activity" EXACT [EC:1.1.1.200]
synonym: "NADP-dependent D-sorbitol-6-phosphate dehydrogenase activity" EXACT [EC:1.1.1.200]
xref: EC:1.1.1.200
xref: KEGG:R00834
xref: MetaCyc:ALDOSE-6-PHOSPHATE-REDUCTASE-NADPH-RXN
xref: RHEA:20040
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047642
name: aldose beta-D-fructosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-aldosyl1 beta-D-fructoside + D-aldose2 = D-aldose1 + alpha-D-aldosyl2 beta-D-fructoside." [EC:2.4.1.162, MetaCyc:ALDOSE-BETA-FRUCTOSYLTRANSFERASE-RXN]
synonym: "aldose b-D-fructosyltransferase activity" EXACT []
synonym: "alpha-D-aldosyl-beta-D-fructoside:aldose 1-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.162]
xref: EC:2.4.1.162
xref: MetaCyc:ALDOSE-BETA-FRUCTOSYLTRANSFERASE-RXN
is_a: GO:0050738 ! fructosyltransferase activity

[Term]
id: GO:0047643
name: alginate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-D-mannuronate + alginate(n) = GDP + alginate(n+1)." [EC:2.4.1.33, MetaCyc:ALGINATE-SYNTHASE-RXN]
synonym: "GDP-D-mannuronate:alginate D-mannuronyltransferase activity" EXACT [EC:2.4.1.33]
synonym: "mannuronosyl transferase activity" EXACT [EC:2.4.1.33]
xref: EC:2.4.1.33
xref: MetaCyc:ALGINATE-SYNTHASE-RXN
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0047644
name: alizarin 2-beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: alizarin + UDP-D-glucose = 1-hydroxy-2-(beta-D-glucosyloxy)-9,10-anthraquinone + H(+) + UDP." [EC:2.4.1.103, RHEA:20680]
synonym: "alizarin 2-b-glucosyltransferase activity" EXACT []
synonym: "UDP-glucose:1,2-dihydroxy-9,10-anthraquinone 2-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.103]
synonym: "UDPglucose:1,2-dihydroxy-9,10-anthraquinone 2-O-beta-D-glucosyl-transferase activity" EXACT [EC:2.4.1.103]
synonym: "uridine diphosphoglucose-alizarin glucosyltransferase activity" EXACT [EC:2.4.1.103]
xref: EC:2.4.1.103
xref: KEGG:R03573
xref: MetaCyc:ALIZARIN-2-BETA-GLUCOSYLTRANSFERASE-RXN
xref: RHEA:20680
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047645
name: alkan-1-ol dehydrogenase (acceptor) activity
namespace: molecular_function
def: "Catalysis of the reaction: primary alcohol + acceptor = aldehyde + reduced acceptor." [EC:1.1.99.20, MetaCyc:ALKAN-1-OL-DEHYDROGENASE-ACCEPTOR-RXN]
synonym: "alkan-1-ol:(acceptor) oxidoreductase activity" EXACT [EC:1.1.99.20]
synonym: "alkan-1-ol:acceptor oxidoreductase activity" EXACT [EC:1.1.99.20]
synonym: "polyethylene glycol dehydrogenase activity" NARROW [EC:1.1.99.20]
xref: EC:1.1.99.20
xref: MetaCyc:ALKAN-1-OL-DEHYDROGENASE-ACCEPTOR-RXN
xref: RHEA:14688
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0047646
name: alkanal monooxygenase (FMN-linked) activity
namespace: molecular_function
def: "Catalysis of the reaction: R-CHO + reduced FMN + O2 = R-COOH + FMN + H2O + light." [EC:1.14.14.3, MetaCyc:ALKANAL-MONOOXYGENASE-FMN-LINKED-RXN]
subset: gosubset_prok
synonym: "aldehyde monooxygenase activity" BROAD [EC:1.14.14.3]
synonym: "alkanal,reduced-FMN:oxygen oxidoreductase (1-hydroxylating, luminescing)" EXACT [EC:1.14.14.3]
synonym: "bacterial luciferase activity" EXACT [EC:1.14.14.3]
synonym: "vibrio fischeri luciferase activity" EXACT [EC:1.14.14.3]
xref: EC:1.14.14.3
xref: MetaCyc:ALKANAL-MONOOXYGENASE-FMN-LINKED-RXN
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047647
name: alkylacetylglycerophosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-alkyl-2-acetyl-sn-glycerol 3-phosphate + H(2)O = 2-acetyl-1-alkyl-sn-glycerol + phosphate." [EC:3.1.3.59, RHEA:18224]
synonym: "1-alkyl-2-acetyl-sn-glycero-3-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.59]
synonym: "1-alkyl-2-lyso-sn-glycero-3-P:acetyl-CoA acetyltransferase activity" EXACT [EC:3.1.3.59]
synonym: "alkylacetylglycerophosphate phosphatase activity" EXACT [EC:3.1.3.59]
xref: EC:3.1.3.59
xref: KEGG:R03454
xref: MetaCyc:ALKYLACETYLGLYCEROPHOSPHATASE-RXN
xref: RHEA:18224
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0047648
name: alkylamidase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-methylhexanamide + H(2)O = hexanoate + methylammonium." [EC:3.5.1.39, RHEA:20084]
synonym: "N-methylhexanamide amidohydrolase activity" EXACT [EC:3.5.1.39]
xref: EC:3.5.1.39
xref: KEGG:R03620
xref: MetaCyc:ALKYLAMIDASE-RXN
xref: RHEA:20084
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047649
name: alkylglycerol kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-alkyl-sn-glycerol + ATP = 1-alkyl-sn-glycerol 3-phosphate + ADP + 2 H(+)." [EC:2.7.1.93, RHEA:16940]
synonym: "1-alkylglycerol kinase (phosphorylating)" EXACT [EC:2.7.1.93]
synonym: "alkylglycerol phosphotransferase activity" EXACT [EC:2.7.1.93]
synonym: "ATP-alkylglycerol phosphotransferase activity" EXACT [EC:2.7.1.93]
synonym: "ATP:1-alkyl-sn-glycerol phosphotransferase activity" EXACT [EC:2.7.1.93]
synonym: "ATP:1-O-alkyl-sn-glycerol 3-phosphotransferase activity" EXACT [EC:2.7.1.93]
xref: EC:2.7.1.93
xref: KEGG:R04126
xref: MetaCyc:ALKYLGLYCEROL-KINASE-RXN
xref: RHEA:16940
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047650
name: alkylglycerone kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: O-alkylglycerone + ATP = O-alkylglycerone phosphate + ADP + 2 H(+)." [EC:2.7.1.84, RHEA:23091]
synonym: "alkyldihydroxyacetone kinase (phosphorylating)" EXACT [EC:2.7.1.84]
synonym: "alkyldihydroxyacetone kinase activity" EXACT [EC:2.7.1.84]
synonym: "ATP:O-alkylglycerone phosphotransferase activity" EXACT [EC:2.7.1.84]
xref: EC:2.7.1.84
xref: KEGG:R03944
xref: MetaCyc:ALKYLGLYCERONE-KINASE-RXN
xref: RHEA:23091
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047651
name: alkylhalidase activity
namespace: molecular_function
def: "Catalysis of the reaction: bromochloromethane + H(2)O = bromide + chloride + formaldehyde + 2 H(+)." [EC:3.8.1.1, RHEA:13768]
subset: gosubset_prok
synonym: "alkyl-halide halidohydrolase activity" EXACT [EC:3.8.1.1]
synonym: "haloalkane halidohydrolase activity" EXACT [EC:3.8.1.1]
synonym: "halogenase activity" RELATED [EC:3.8.1.1]
xref: EC:3.8.1.1
xref: KEGG:R03523
xref: MetaCyc:ALKYLHALIDASE-RXN
xref: RHEA:13768
is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds

[Term]
id: GO:0047652
name: allantoate deiminase activity
namespace: molecular_function
def: "Catalysis of the reaction: allantoate + H2O + H+ = CO2 + NH3 + ureidoglycine." [EC:3.5.3.9, MetaCyc:ALLANTOATE-DEIMINASE-RXN]
synonym: "allantoate amidinohydrolase (decarboxylating)" EXACT [EC:3.5.3.9]
synonym: "allantoate amidohydrolase activity" EXACT [EC:3.5.3.9]
xref: EC:3.5.3.9
xref: MetaCyc:ALLANTOATE-DEIMINASE-RXN
xref: RHEA:27488
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0047653
name: allantoin racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-(+)-allantoin = (R)-(-)-allantoin." [EC:5.1.99.3, RHEA:10807]
xref: EC:5.1.99.3
xref: KEGG:R03925
xref: MetaCyc:ALLANTOIN-RACEMASE-RXN
xref: RHEA:10807
is_a: GO:0016854 ! racemase and epimerase activity

[Term]
id: GO:0047654
name: alliin lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: an S-alkyl-L-cysteine S-oxide = an alkyl sulfenate + 2-aminoacrylate." [EC:4.4.1.4, MetaCyc:ALLIIN-LYASE-RXN]
synonym: "alkylcysteine sulfoxide lyase activity" EXACT [EC:4.4.1.4]
synonym: "alliin alkyl-sulfenate-lyase activity" EXACT [EC:4.4.1.4]
synonym: "alliinase activity" EXACT [EC:4.4.1.4]
synonym: "cysteine sulfoxide lyase activity" EXACT [EC:4.4.1.4]
synonym: "cysteine sulphoxide lyase activity" EXACT [EC:4.4.1.4]
synonym: "L-cysteine sulfoxide lyase activity" EXACT [EC:4.4.1.4]
synonym: "S-alkyl-L-cysteine S-oxide alkyl-sulfenate-lyase (2-aminoacrylate-forming)" EXACT [EC:4.4.1.4]
synonym: "S-alkylcysteine sulfoxide lyase activity" EXACT [EC:4.4.1.4]
xref: EC:4.4.1.4
xref: MetaCyc:ALLIIN-LYASE-RXN
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0047655
name: allyl-alcohol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: allyl alcohol + NADP(+) = acrolein + H(+) + NADPH." [EC:1.1.1.54, RHEA:12171]
synonym: "allyl-alcohol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.54]
xref: EC:1.1.1.54
xref: KEGG:R03572
xref: MetaCyc:ALLYL-ALCOHOL-DEHYDROGENASE-RXN
xref: RHEA:12171
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047656
name: alpha,alpha-trehalose phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha,alpha-trehalose + phosphate = D-glucose + beta-D-glucose 1-phosphate." [EC:2.4.1.64, MetaCyc:ALPHAALPHA-TREHALOSE-PHOSPHORYLASE-RXN]
subset: gosubset_prok
synonym: "a,a-trehalose phosphorylase activity" EXACT []
synonym: "alpha,alpha-trehalose:phosphate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.64]
synonym: "trehalose phosphorylase" BROAD [EC:2.4.1.64]
xref: EC:2.4.1.64
xref: MetaCyc:ALPHAALPHA-TREHALOSE-PHOSPHORYLASE-RXN
xref: RHEA:23515
is_a: GO:0004645 ! phosphorylase activity

[Term]
id: GO:0047657
name: alpha-1,3-glucan synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + [alpha-D-glucosyl-(1,3)]n = UDP + [alpha-D-glucosyl-(1,3)]n+1." [EC:2.4.1.183, MetaCyc:ALPHA-13-GLUCAN-SYNTHASE-RXN]
synonym: "1,3-alpha-D-glucan synthase activity" EXACT [EC:2.4.1.183]
synonym: "1,3-alpha-glucan synthase activity" EXACT []
synonym: "a-1,3-glucan synthase activity" EXACT []
synonym: "UDP-glucose:alpha-D-(1->3)-glucan 3-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.183]
synonym: "UDPglucose:alpha-D-(1->3)-glucan 3-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.183]
synonym: "uridine diphosphoglucose-1,3-alpha-glucan glucosyltransferase activity" EXACT [EC:2.4.1.183]
xref: EC:2.4.1.183
xref: MetaCyc:ALPHA-13-GLUCAN-SYNTHASE-RXN
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0047658
name: alpha-amino-acid esterase activity
namespace: molecular_function
def: "Catalysis of the reaction: an alpha-amino acid ester + H2O = an alpha-amino acid + an alcohol." [EC:3.1.1.43, MetaCyc:ALPHA-AMINO-ACID-ESTERASE-RXN]
subset: gosubset_prok
synonym: "a-amino-acid esterase activity" EXACT []
synonym: "alpha-amino acid ester hydrolase activity" EXACT [EC:3.1.1.43]
synonym: "alpha-amino-acid ester hydrolase activity" EXACT [EC:3.1.1.43]
synonym: "alpha-amino-acid-ester aminoacylhydrolase activity" EXACT [EC:3.1.1.43]
xref: EC:3.1.1.43
xref: MetaCyc:ALPHA-AMINO-ACID-ESTERASE-RXN
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0047659
name: alpha-santonin 1,2-reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-dihydrosantonin + NAD(P)+ = alpha-santonin + NAD(P)H + H+." [EC:1.3.1.47, MetaCyc:ALPHA-SANTONIN-12-REDUCTASE-RXN]
synonym: "1,2-dihydrosantonin:NAD(P)+ 1,2-oxidoreductase activity" EXACT [EC:1.3.1.47]
synonym: "a-santonin 1,2-reductase activity" EXACT []
xref: EC:1.3.1.47
xref: MetaCyc:ALPHA-SANTONIN-12-REDUCTASE-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047660
name: amidinoaspartase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-amidino-L-aspartate + H(2)O = L-aspartate + urea." [EC:3.5.3.14, RHEA:14852]
synonym: "amidinoaspartic amidinohydrolase activity" EXACT [EC:3.5.3.14]
synonym: "N-amidino-L-aspartate amidinohydrolase activity" EXACT [EC:3.5.3.14]
xref: EC:3.5.3.14
xref: KEGG:R00777
xref: MetaCyc:AMIDINOASPARTASE-RXN
xref: RHEA:14852
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0047661
name: amino-acid racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: an L-amino acid = a D-amino acid." [EC:5.1.1.10, MetaCyc:AMINO-ACID-RACEMASE-RXN]
subset: gosubset_prok
synonym: "L-amino acid racemase activity" EXACT [EC:5.1.1.10]
xref: EC:5.1.1.10
xref: MetaCyc:AMINO-ACID-RACEMASE-RXN
xref: RHEA:18320
is_a: GO:0036361 ! racemase activity, acting on amino acids and derivatives

[Term]
id: GO:0047662
name: aminobenzoate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4(or 2)-aminobenzoate = aniline + CO2." [EC:4.1.1.24, MetaCyc:AMINOBENZOATE-DECARBOXYLASE-RXN]
synonym: "aminobenzoate carboxy-lyase (aniline-forming)" EXACT [EC:4.1.1.24]
synonym: "aminobenzoate carboxy-lyase activity" EXACT [EC:4.1.1.24]
xref: EC:4.1.1.24
xref: MetaCyc:AMINOBENZOATE-DECARBOXYLASE-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047663
name: aminoglycoside 6'-N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + kanamycin B = N(6')-acetylkanamycin B + CoA + H(+). This is acetylation of the 6'-amino group of the 6-deoxy-6-aminoglucose ring." [EC:2.3.1.82, RHEA:16452]
subset: gosubset_prok
synonym: "6'-aminoglycoside-N-acetyltransferase activity" EXACT [EC:2.3.1.82]
synonym: "AAC(6') activity" RELATED [EC:2.3.1.82]
synonym: "acetyl-CoA:kanamycin-B N6'-acetyltransferase activity" NARROW [EC:2.3.1.82]
synonym: "aminoglycoside N6'-acetyltransferase activity" EXACT []
synonym: "aminoglycoside-6'-acetyltransferase activity" EXACT [EC:2.3.1.82]
synonym: "aminoglycoside-6-N-acetyltransferase activity" EXACT [EC:2.3.1.82]
synonym: "kanamycin 6'-N-acetyltransferase activity" NARROW []
xref: EC:2.3.1.82
xref: KEGG:R01889
xref: MetaCyc:AMINOGLYCOSIDE-N6-ACETYLTRANSFERASE-RXN
xref: RHEA:16452
is_a: GO:0034069 ! aminoglycoside N-acetyltransferase activity

[Term]
id: GO:0047664
name: aminoimidazolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-aminoimidazole + H2O = unidentified product + NH3." [EC:3.5.4.8, MetaCyc:AMINOIMIDAZOLASE-RXN]
synonym: "4-aminoimidazole aminohydrolase activity" EXACT [EC:3.5.4.8]
synonym: "4-aminoimidazole hydrolase activity" EXACT [EC:3.5.4.8]
xref: EC:3.5.4.8
xref: MetaCyc:R13-RXN
xref: RHEA:24947
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines

[Term]
id: GO:0047665
name: aminolevulinate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-aminolevulinate + pyruvate = 4,5-dioxopentanoate + L-alanine." [EC:2.6.1.43, RHEA:12483]
synonym: "4,5-dioxovalerate aminotransferase activity" EXACT [EC:2.6.1.43]
synonym: "4,5-dioxovaleric acid aminotransferase activity" EXACT [EC:2.6.1.43]
synonym: "4,5-dioxovaleric acid transaminase activity" EXACT [EC:2.6.1.43]
synonym: "4,5-dioxovaleric transaminase activity" EXACT [EC:2.6.1.43]
synonym: "5-aminolevulinate:pyruvate aminotransferase activity" EXACT [EC:2.6.1.43]
synonym: "5-aminolevulinic acid transaminase activity" EXACT [EC:2.6.1.43]
synonym: "alanine-dioxovalerate aminotransferase activity" EXACT [EC:2.6.1.43]
synonym: "alanine-gamma,delta-dioxovalerate aminotransferase activity" EXACT [EC:2.6.1.43]
synonym: "alanine:4,5-dioxovalerate aminotransferase activity" EXACT [EC:2.6.1.43]
synonym: "aminolevulinate aminotransferase activity" EXACT []
synonym: "aminolevulinic acid transaminase activity" EXACT [EC:2.6.1.43]
synonym: "dioxovalerate transaminase activity" EXACT [EC:2.6.1.43]
synonym: "DOVA transaminase activity" EXACT [EC:2.6.1.43]
synonym: "gamma,delta-dioxovalerate aminotransferase activity" EXACT [EC:2.6.1.43]
synonym: "gamma,delta-dioxovaleric acid transaminase activity" EXACT [EC:2.6.1.43]
synonym: "L-alanine-4,5-dioxovalerate aminotransferase activity" EXACT [EC:2.6.1.43]
synonym: "L-alanine:4,5-dioxovaleric acid transaminase activity" EXACT [EC:2.6.1.43]
synonym: "L-alanine:dioxovalerate transaminase activity" EXACT [EC:2.6.1.43]
xref: EC:2.6.1.43
xref: KEGG:R02271
xref: MetaCyc:AMINOLEVULINATE-AMINOTRANSFERASE-RXN
xref: RHEA:12483
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047666
name: ammonia kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + NH(4)(+) = ADP + 3 H(+) + phosphoramidate." [EC:2.7.3.8, RHEA:11027]
synonym: "ATP:ammonia phosphotransferase activity" EXACT [EC:2.7.3.8]
synonym: "phosphoramidate-adenosine diphosphate phosphotransferase activity" EXACT [EC:2.7.3.8]
synonym: "phosphoramidate-ADP-phosphotransferase activity" EXACT [EC:2.7.3.8]
xref: EC:2.7.3.8
xref: KEGG:R00141
xref: MetaCyc:AMMONIA-KINASE-RXN
xref: RHEA:11027
is_a: GO:0016301 ! kinase activity
is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor

[Term]
id: GO:0047667
name: AMP-thymidine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: AMP + thymidine = adenosine + thymidine 5'-phosphate." [EC:2.7.1.114, MetaCyc:AMP--THYMIDINE-KINASE-RXN]
synonym: "adenylate-nucleoside phosphotransferase activity" EXACT [EC:2.7.1.114]
synonym: "adenylic acid:deoxythymidine 5'-phosphotransferase activity" EXACT [EC:2.7.1.114]
synonym: "AMP:deoxythymidine 5'-phosphotransferase activity" EXACT [EC:2.7.1.114]
synonym: "AMP:deoxythymidine kinase activity" EXACT [EC:2.7.1.114]
synonym: "AMP:dThd kinase activity" EXACT [EC:2.7.1.114]
synonym: "AMP:thymidine 5'-phosphotransferase activity" EXACT [EC:2.7.1.114]
synonym: "thymidine phosphotransferase activity" EXACT [EC:2.7.1.114]
xref: EC:2.7.1.114
xref: MetaCyc:AMP--THYMIDINE-KINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047668
name: amygdalin beta-glucosidase activity
namespace: molecular_function
alt_id: GO:0080080
def: "Catalysis of the reaction: (R)-amygdalin + H(2)O = (R)-prunasin + D-glucose." [EC:3.2.1.117, RHEA:14180]
synonym: "(R)-amygdalin beta-glucosidase activity" EXACT []
synonym: "amygdalin b-glucosidase activity" EXACT []
synonym: "amygdalin beta-D-glucohydrolase activity" EXACT [EC:3.2.1.117]
synonym: "amygdalin glucosidase activity" EXACT [EC:3.2.1.117]
synonym: "amygdalin hydrolase activity" EXACT [EC:3.2.1.117]
synonym: "amygdalinase" BROAD [EC:3.2.1.117]
xref: EC:3.2.1.117
xref: KEGG:R02985
xref: MetaCyc:AMYGDALIN-BETA-GLUCOSIDASE-RXN
xref: RHEA:14180
is_a: GO:0008422 ! beta-glucosidase activity

[Term]
id: GO:0047669
name: amylosucrase activity
namespace: molecular_function
def: "Catalysis of the reaction: sucrose + 1,4-alpha-D-glucosyl(n) = D-fructose + 1,4-alpha-D-glucosyl(n+1)." [EC:2.4.1.4, MetaCyc:AMYLOSUCRASE-RXN]
subset: gosubset_prok
synonym: "sucrose-1,4-alpha-glucan glucosyltransferase activity" EXACT [EC:2.4.1.4]
synonym: "sucrose-glucan glucosyltransferase activity" EXACT [EC:2.4.1.4]
synonym: "sucrose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.4]
xref: EC:2.4.1.4
xref: MetaCyc:AMYLOSUCRASE-RXN
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0047670
name: anhydrotetracycline monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: anhydrotetracycline + H(+) + NADPH + O(2) = 12-dehydrotetracycline + H(2)O + NADP(+)." [EC:1.14.13.38, RHEA:11979]
synonym: "anhydrotetracycline oxygenase activity" EXACT [EC:1.14.13.38]
synonym: "anhydrotetracycline,NADPH:oxygen oxidoreductase (6-hydroxylating)" EXACT [EC:1.14.13.38]
synonym: "ATC oxygenase activity" EXACT [EC:1.14.13.38]
xref: EC:1.14.13.38
xref: KEGG:R04060
xref: MetaCyc:ANHYDROTETRACYCLINE-MONOOXYGENASE-RXN
xref: RHEA:11979
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047671
name: anthranilate adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: anthranilate + ATP = N-adenylylanthranilate + diphosphate + H(+)." [EC:2.7.7.55, RHEA:22415]
synonym: "anthranilic acid adenylyltransferase activity" EXACT [EC:2.7.7.55]
synonym: "ATP:anthranilate adenylyltransferase activity" EXACT []
synonym: "ATP:anthranilate N-adenylyltransferase activity" EXACT [EC:2.7.7.55]
xref: EC:2.7.7.55
xref: KEGG:R00979
xref: MetaCyc:ANTHRANILATE-ADENYLYLTRANSFERASE-RXN
xref: RHEA:22415
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0047672
name: anthranilate N-benzoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: anthranilate + benzoyl-CoA = N-benzoylanthranilate + CoA." [EC:2.3.1.144, RHEA:21603]
synonym: "benzoyl-CoA:anthranilate N-benzoyltransferase" BROAD [EC:2.3.1.144]
xref: EC:2.3.1.144
xref: KEGG:R02453
xref: MetaCyc:ANTHRANILATE-N-BENZOYLTRANSFERASE-RXN
xref: RHEA:21603
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0047673
name: anthranilate N-malonyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: anthranilate + malonyl-CoA = N-malonylanthranilate + CoA." [EC:2.3.1.113, RHEA:17560]
synonym: "malonyl-CoA:anthranilate N-malonyltransferase activity" EXACT [EC:2.3.1.113]
xref: EC:2.3.1.113
xref: KEGG:R00989
xref: MetaCyc:ANTHRANILATE-N-MALONYLTRANSFERASE-RXN
xref: RHEA:17560
is_a: GO:0050735 ! N-malonyltransferase activity

[Term]
id: GO:0047674
name: apiose 1-reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-apiitol + NAD(+) = D-apiose + H(+) + NADH." [EC:1.1.1.114, RHEA:15304]
synonym: "D-apiitol reductase activity" EXACT [EC:1.1.1.114]
synonym: "D-apiitol:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.114]
synonym: "D-apiose reductase activity" EXACT [EC:1.1.1.114]
xref: EC:1.1.1.114
xref: KEGG:R03577
xref: MetaCyc:APIOSE-1-REDUCTASE-RXN
xref: RHEA:15304
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047675
name: arabinonate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-arabinonate = 2-dehydro-3-deoxy-D-arabinonate + H(2)O." [EC:4.2.1.5, RHEA:21839]
synonym: "D-arabinonate hydro-lyase (2-dehydro-3-deoxy-D-arabinonate-forming)" EXACT [EC:4.2.1.5]
synonym: "D-arabinonate hydro-lyase activity" EXACT [EC:4.2.1.5]
xref: EC:4.2.1.5
xref: KEGG:R03032
xref: MetaCyc:ARABINONATE-DEHYDRATASE-RXN
xref: RHEA:21839
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047676
name: arachidonate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: arachidonate + ATP + CoA = AMP + arachidonoyl-CoA + diphosphate + H(+)." [EC:6.2.1.15, RHEA:19716]
synonym: "arachidonate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.15]
synonym: "arachidonoyl-CoA synthetase activity" EXACT [EC:6.2.1.15]
xref: EC:6.2.1.15
xref: KEGG:R01598
xref: MetaCyc:ARACHIDONATE--COA-LIGASE-RXN
xref: RHEA:19716
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0047677
name: arachidonate 8(R)-lipoxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: arachidonate + O(2) = (5Z,8R,9E,11Z,14Z)-8-hydroperoxyicosa-5,9,11,14-tetraenoate." [EC:1.13.11.40, RHEA:14988]
comment: This activity produces the R-enantiomer of HPETE, 8(R)-HPETE. For the reaction producing the S-enantiomer, see GO:0036403.
synonym: "8(R)-lipoxygenase activity" EXACT [EC:1.13.11.40]
synonym: "8-lipoxygenase activity" NARROW [EC:1.13.11.40]
synonym: "arachidonate 8-lipoxygenase activity" BROAD [GOC:lb]
synonym: "arachidonate:oxygen 8-oxidoreductase activity" EXACT [EC:1.13.11.40]
xref: EC:1.13.11.40
xref: KEGG:R01594
xref: MetaCyc:ARACHIDONATE-8-LIPOXYGENASE-RXN
xref: RHEA:14988
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0047678
name: arginine 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arginine + O(2) = 4-guanidinobutanamide + CO(2) + H(2)O." [EC:1.13.12.1, RHEA:10551]
synonym: "arginine decarboxy-oxidase activity" EXACT [EC:1.13.12.1]
synonym: "arginine monooxygenase activity" EXACT [EC:1.13.12.1]
synonym: "arginine oxygenase (decarboxylating) activity" EXACT [EC:1.13.12.1]
synonym: "L-arginine:oxygen 2-oxidoreductase (decarboxylating)" EXACT [EC:1.13.12.1]
xref: EC:1.13.12.1
xref: KEGG:R00559
xref: MetaCyc:ARGININE-2-MONOOXYGENASE-RXN
xref: RHEA:10551
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)

[Term]
id: GO:0047679
name: arginine racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arginine = D-arginine." [EC:5.1.1.9, MetaCyc:ARGININE-RACEMASE-RXN]
xref: EC:5.1.1.9
xref: MetaCyc:ARGININE-RACEMASE-RXN
xref: RHEA:18072
is_a: GO:0047661 ! amino-acid racemase activity

[Term]
id: GO:0047680
name: aryl-acylamidase activity
namespace: molecular_function
def: "Catalysis of the reaction: anilide + H(2)O = a carboxylate + aniline + H(+)." [EC:3.5.1.13, RHEA:20300]
subset: gosubset_prok
synonym: "AAA-1" RELATED [EC:3.5.1.13]
synonym: "AAA-2" RELATED [EC:3.5.1.13]
synonym: "aryl-acylamide amidohydrolase activity" EXACT [EC:3.5.1.13]
synonym: "brain acetylcholinesterase (is associated with AAA-2)" EXACT [EC:3.5.1.13]
synonym: "pseudocholinesterase (associated with arylacylamidase)" EXACT [EC:3.5.1.13]
xref: EC:3.5.1.13
xref: KEGG:R01862
xref: MetaCyc:ARYL-ACYLAMIDASE-RXN
xref: RHEA:20300
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047681
name: aryl-alcohol dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: an aromatic alcohol + NADP+ = an aromatic aldehyde + NADPH." [EC:1.1.1.91, MetaCyc:ARYL-ALCOHOL-DEHYDROGENASE-NADP+-RXN]
synonym: "aryl alcohol dehydrogenase (nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.1.1.91]
synonym: "aryl-alcohol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.91]
synonym: "NADPH-linked benzaldehyde reductase activity" EXACT [EC:1.1.1.91]
xref: EC:1.1.1.91
xref: MetaCyc:ARYL-ALCOHOL-DEHYDROGENASE-NADP+-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047682
name: aryl-alcohol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: an aromatic primary alcohol + O2 = an aromatic aldehyde + H2O2." [EC:1.1.3.7, MetaCyc:ARYL-ALCOHOL-OXIDASE-RXN]
synonym: "arom. alcohol oxidase activity" EXACT [EC:1.1.3.7]
synonym: "aryl alcohol oxidase activity" EXACT [EC:1.1.3.7]
synonym: "aryl-alcohol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.7]
synonym: "veratryl alcohol oxidase activity" NARROW [EC:1.1.3.7]
xref: EC:1.1.3.7
xref: MetaCyc:ARYL-ALCOHOL-OXIDASE-RXN
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0047683
name: aryl-aldehyde dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: an aromatic aldehyde + NADP+ + AMP + diphosphate + H2O = an aromatic acid + NADPH + ATP." [EC:1.2.1.30, MetaCyc:ARYL-ALDEHYDE-DEHYDROGENASE-NADP+-RXN]
synonym: "aromatic acid reductase activity" EXACT [EC:1.2.1.30]
synonym: "aryl-aldehyde:NADP+ oxidoreductase (ATP-forming)" EXACT [EC:1.2.1.30]
xref: EC:1.2.1.30
xref: MetaCyc:ARYL-ALDEHYDE-DEHYDROGENASE-NADP+-RXN
is_a: GO:0033721 ! aldehyde dehydrogenase (NADP+) activity

[Term]
id: GO:0047684
name: arylamine glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + an arylamine = UDP + an N-D-glucosylarylamine." [EC:2.4.1.71, MetaCyc:ARYLAMINE-GLUCOSYLTRANSFERASE-RXN]
synonym: "UDP glucose-arylamine glucosyltransferase activity" EXACT [EC:2.4.1.71]
synonym: "UDP-glucose:arylamine N-D-glucosyltransferase activity" EXACT [EC:2.4.1.71]
synonym: "UDPglucose:arylamine N-D-glucosyltransferase activity" EXACT [EC:2.4.1.71]
synonym: "uridine diphosphoglucose-arylamine glucosyltransferase activity" EXACT [EC:2.4.1.71]
xref: EC:2.4.1.71
xref: MetaCyc:ARYLAMINE-GLUCOSYLTRANSFERASE-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047685
name: amine sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an amine = adenosine 3',5'-bisphosphate + a sulfamate." [EC:2.8.2.3, MetaCyc:ARYLAMINE-SULFOTRANSFERASE-RXN]
synonym: "3'-phosphoadenylyl-sulfate:amine N-sulfotransferase activity" EXACT [EC:2.8.2.3]
synonym: "amine N-sulfotransferase activity" EXACT [EC:2.8.2.3]
synonym: "amine sulphotransferase activity" EXACT []
synonym: "arylamine sulfotransferase activity" EXACT []
xref: EC:2.8.2.3
xref: MetaCyc:ARYLAMINE-SULFOTRANSFERASE-RXN
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0047686
name: arylsulfate sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: an aryl sulfate + a phenol = a phenol + an aryl sulfate." [EC:2.8.2.22, MetaCyc:ARYLSULFATE-SULFOTRANSFERASE-RXN]
subset: gosubset_prok
synonym: "arylsulfate-phenol sulfotransferase activity" EXACT [EC:2.8.2.22]
synonym: "arylsulfate:phenol sulfotransferase activity" EXACT [EC:2.8.2.22]
synonym: "arylsulfotransferase" BROAD [EC:2.8.2.22]
synonym: "arylsulphate sulphotransferase activity" EXACT []
synonym: "ASST" RELATED [EC:2.8.2.22]
xref: EC:2.8.2.22
xref: MetaCyc:ARYLSULFATE-SULFOTRANSFERASE-RXN
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0047687
name: obsolete ascorbate 2,3-dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: L-ascorbate + H(2)O + O(2) = L-threonate + 2 H(+) + oxalate." [EC:1.13.11.13, RHEA:21787]
comment: This term was made obsolete because EC:1.13.11.13 was deleted; the activity is the sum of several enzymatic and spontaneous reactions.
synonym: "AAoxygenase activity" EXACT [EC:1.13.11.13]
synonym: "ascorbate 2,3-dioxygenase activity" EXACT []
synonym: "ascorbate:oxygen 2,3-oxidoreductase (bond-cleaving)" EXACT [EC:1.13.11.13]
xref: EC:1.13.11.13
xref: KEGG:R00646
xref: MetaCyc:ASCORBATE-23-DIOXYGENASE-RXN
xref: RHEA:21787
is_obsolete: true

[Term]
id: GO:0047688
name: aspartate 4-decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-aspartate = L-alanine + CO2." [EC:4.1.1.12, MetaCyc:ASPARTATE-4-DECARBOXYLASE-RXN]
subset: gosubset_prok
synonym: "aminomalonic decarboxylase activity" EXACT [EC:4.1.1.12]
synonym: "aspartate beta-decarboxylase activity" EXACT [EC:4.1.1.12]
synonym: "aspartate omega-decarboxylase activity" EXACT [EC:4.1.1.12]
synonym: "aspartic beta-decarboxylase activity" EXACT [EC:4.1.1.12]
synonym: "aspartic omega-decarboxylase activity" EXACT [EC:4.1.1.12]
synonym: "cysteine sulfinic desulfinase activity" EXACT [EC:4.1.1.12]
synonym: "desulfinase activity" EXACT [EC:4.1.1.12]
synonym: "L-aspartate 4-carboxy-lyase (L-alanine-forming)" EXACT [EC:4.1.1.12]
synonym: "L-aspartate 4-carboxy-lyase activity" EXACT [EC:4.1.1.12]
synonym: "L-aspartate beta-decarboxylase activity" EXACT [EC:4.1.1.12]
synonym: "L-cysteine sulfinate acid desulfinase activity" EXACT [EC:4.1.1.12]
xref: EC:4.1.1.12
xref: MetaCyc:ASPARTATE-4-DECARBOXYLASE-RXN
xref: RHEA:12624
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047689
name: aspartate racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-aspartate = D-aspartate." [EC:5.1.1.13, RHEA:14976]
subset: gosubset_prok
synonym: "D-aspartate racemase activity" EXACT [EC:5.1.1.13]
xref: EC:5.1.1.13
xref: KEGG:R00491
xref: MetaCyc:ASPARTATE-RACEMASE-RXN
xref: RHEA:14976
is_a: GO:0047661 ! amino-acid racemase activity

[Term]
id: GO:0047690
name: aspartyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-asparagine + H(+) + hydroxylamine = beta-L-aspartylhydroxamate + NH(4)(+)." [EC:2.3.2.7, RHEA:11255]
synonym: "aspartotransferase activity" EXACT [EC:2.3.2.7]
synonym: "beta-aspartyl transferase activity" EXACT [EC:2.3.2.7]
synonym: "L-asparagine:hydroxylamine gamma-aspartyltransferase activity" EXACT [EC:2.3.2.7]
xref: EC:2.3.2.7
xref: KEGG:R01485
xref: MetaCyc:ASPARTYLTRANSFERASE-RXN
xref: RHEA:11255
is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups

[Term]
id: GO:0047691
name: aspulvinone dimethylallyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: aspulvinone E + 2 dimethylallyl diphosphate = aspulvinone H + 2 diphosphate." [EC:2.5.1.35, RHEA:13812]
synonym: "dimethylallyl pyrophosphate:aspulvinone dimethylallyltransferase activity" EXACT [EC:2.5.1.35]
synonym: "dimethylallyl-diphosphate:aspulvinone-E dimethylallyltransferase activity" EXACT [EC:2.5.1.35]
xref: EC:2.5.1.35
xref: KEGG:R03799
xref: MetaCyc:ASPULVINONE-DIMETHYLALLYLTRANSFERASE-RXN
xref: RHEA:13812
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0047692
name: ATP deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ITP + NH3." [EC:3.5.4.18, MetaCyc:ATP-DEAMINASE-RXN]
synonym: "adenosine triphosphate deaminase activity" EXACT [EC:3.5.4.18]
synonym: "ATP aminohydrolase activity" EXACT [EC:3.5.4.18]
xref: EC:3.5.4.18
xref: MetaCyc:ATP-DEAMINASE-RXN
xref: RHEA:13040
is_a: GO:0047623 ! adenosine-phosphate deaminase activity

[Term]
id: GO:0047693
name: ATP diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = AMP + diphosphate." [EC:3.6.1.8, MetaCyc:ATP-PYROPHOSPHATASE-RXN]
subset: gosubset_prok
synonym: "adenosine triphosphate pyrophosphatase activity" EXACT [EC:3.6.1.8]
synonym: "ATP diphosphohydrolase" BROAD [EC:3.6.1.8]
synonym: "ATP diphosphohydrolase (diphosphate-forming)" EXACT [EC:3.6.1.8]
synonym: "ATP pyrophosphatase activity" EXACT []
xref: EC:3.6.1.8
xref: MetaCyc:ATP-PYROPHOSPHATASE-RXN
xref: RHEA:14248
is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity

[Term]
id: GO:0047694
name: barbiturase activity
namespace: molecular_function
def: "Catalysis of the reaction: barbiturate + H2O = malonate + urea." [EC:3.5.2.1, MetaCyc:BARBITURASE-RXN]
synonym: "barbiturate amidohydrolase (3-oxo-3-ureidopropanoate-forming)" EXACT [EC:3.5.2.1]
xref: EC:3.5.2.1
xref: MetaCyc:BARBITURASE-RXN
xref: RHEA:18656
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0047695
name: benzoin aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzoin = 2 benzaldehyde." [EC:4.1.2.38, RHEA:21463]
subset: gosubset_prok
synonym: "2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase 2-hydroxy-1,2- activity" EXACT [EC:4.1.2.38]
synonym: "2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase 2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase (benzaldehyde-forming)" EXACT [EC:4.1.2.38]
synonym: "2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase 2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase activity" EXACT [EC:4.1.2.38]
synonym: "benzaldehyde lyase activity" EXACT [EC:4.1.2.38]
synonym: "diphenylethanone benzaldehyde-lyase activity" EXACT [EC:4.1.2.38]
xref: EC:4.1.2.38
xref: KEGG:R00027
xref: MetaCyc:BENZOIN-ALDOLASE-RXN
xref: RHEA:21463
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0047696
name: beta-adrenergic receptor kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + beta-adrenergic receptor = ADP + phospho-beta-adrenergic receptor." [EC:2.7.11.15, MetaCyc:BETA-ADRENERGIC-RECEPTOR-KINASE-RXN]
synonym: "[b-adrenergic-receptor] kinase activity" EXACT [EC:2.7.11.15]
synonym: "ADRBK1" RELATED [EC:2.7.11.15]
synonym: "adrenergic receptor kinase activity" BROAD [EC:2.7.11.15]
synonym: "ATP:beta-adrenergic-receptor phosphotransferase activity" BROAD [EC:2.7.11.15]
synonym: "BARK1" RELATED [EC:2.7.11.15]
synonym: "beta-adrenergic receptor-specific kinase activity" EXACT [EC:2.7.11.15]
synonym: "beta-adrenergic-receptor kinase (phosphorylating) activity" EXACT [EC:2.7.11.15]
synonym: "beta-adrenergic-receptor kinase activity" EXACT [EC:2.7.11.15]
synonym: "beta-adrenoceptor kinase 1 activity" NARROW [EC:2.7.11.15]
synonym: "beta-adrenoceptor kinase 2 activity" NARROW [EC:2.7.11.15]
synonym: "beta-adrenoceptor kinase activity" EXACT [EC:2.7.11.15]
synonym: "beta-AR kinase activity" EXACT [EC:2.7.11.15]
synonym: "beta-ARK" RELATED [EC:2.7.11.15]
synonym: "beta-ARK 1" RELATED [EC:2.7.11.15]
synonym: "beta-ARK 2" RELATED [EC:2.7.11.15]
synonym: "beta-receptor kinase activity" EXACT [EC:2.7.11.15]
synonym: "beta2ARK" RELATED [EC:2.7.11.15]
synonym: "betaARK1" RELATED [EC:2.7.11.15]
synonym: "GRK2" RELATED [EC:2.7.11.15]
synonym: "GRK3" RELATED [EC:2.7.11.15]
synonym: "STK15" RELATED [EC:2.7.11.15]
xref: EC:2.7.11.15
is_a: GO:0004672 ! protein kinase activity

[Term]
id: GO:0047697
name: beta-alanopine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-beta-alanopine + H(2)O + NAD(+) = beta-alanine + H(+) + NADH + pyruvate." [EC:1.5.1.26, RHEA:21687]
synonym: "b-alanopine dehydrogenase activity" EXACT []
synonym: "N-(D-1-carboxyethyl)-beta-alanine:NAD+ oxidoreductase (beta-alanine-forming)" EXACT [EC:1.5.1.26]
xref: EC:1.5.1.26
xref: KEGG:R00906
xref: MetaCyc:BETA-ALANOPINE-DEHYDROGENASE-RXN
xref: RHEA:21687
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047698
name: beta-alanyl-CoA ammonia-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-alanyl-CoA = acryloyl-CoA + NH3." [EC:4.3.1.6, MetaCyc:BETA-ALANYL-COA-AMMONIA-LYASE-RXN]
synonym: "b-alanyl-CoA ammonia-lyase activity" EXACT []
synonym: "beta-alanyl coenzyme A ammonia-lyase activity" EXACT [EC:4.3.1.6]
synonym: "beta-alanyl-CoA ammonia-lyase (acryloyl-CoA-forming)" EXACT [EC:4.3.1.6]
xref: EC:4.3.1.6
xref: MetaCyc:BETA-ALANYL-COA-AMMONIA-LYASE-RXN
xref: RHEA:12419
is_a: GO:0016841 ! ammonia-lyase activity

[Term]
id: GO:0047699
name: beta-diketone hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + nonane-4,6-dione = butanoate + H(+) + pentan-2-one." [EC:3.7.1.7, RHEA:11911]
synonym: "b-diketone hydrolase activity" EXACT []
synonym: "nonane-4,6-dione acylhydrolase activity" EXACT [EC:3.7.1.7]
synonym: "oxidized PVA hydrolase activity" EXACT [EC:3.7.1.7]
xref: EC:3.7.1.7
xref: KEGG:R03781
xref: MetaCyc:BETA-DIKETONE-HYDROLASE-RXN
xref: RHEA:11911
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0047700
name: beta-glucoside kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + cellobiose = ADP + 6-phospho-beta-D-glucosyl-(1,4)-D-glucose." [EC:2.7.1.85, MetaCyc:BETA-GLUCOSIDE-KINASE-RXN]
subset: gosubset_prok
synonym: "ATP:cellobiose 6-phosphotransferase activity" EXACT [EC:2.7.1.85]
synonym: "b-glucoside kinase activity" EXACT []
synonym: "beta-D-glucoside kinase (phosphorylating)" EXACT [EC:2.7.1.85]
xref: EC:2.7.1.85
xref: MetaCyc:BETA-GLUCOSIDE-KINASE-RXN
xref: RHEA:21947
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047701
name: beta-L-arabinosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + a beta-L-arabinoside = L-arabinose + an alcohol." [EC:3.2.1.88, MetaCyc:BETA-L-ARABINOSIDASE-RXN]
synonym: "b-L-arabinosidase activity" EXACT []
synonym: "beta-L-arabinoside arabinohydrolase activity" EXACT [EC:3.2.1.88]
synonym: "vicianosidase activity" EXACT [EC:3.2.1.88]
xref: EC:3.2.1.88
xref: MetaCyc:BETA-L-ARABINOSIDASE-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0047702
name: beta-lysine 5,6-aminomutase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3S)-3,6-diaminohexanoate = (3S,5S)-3,5-diaminohexanoate." [EC:5.4.3.3, RHEA:21739]
subset: gosubset_prok
synonym: "(3S)-3,6-diaminohexanoate 5,6-aminomutase activity" EXACT [EC:5.4.3.3]
synonym: "b-lysine 5,6-aminomutase activity" EXACT []
synonym: "beta-lysine mutase activity" EXACT [EC:5.4.3.3]
synonym: "L-beta-lysine 5,6-aminomutase activity" EXACT [EC:5.4.3.3]
xref: EC:5.4.3.3
xref: KEGG:R03275
xref: MetaCyc:BETA-LYSINE-56-AMINOMUTASE-RXN
xref: RHEA:21739
is_a: GO:0016869 ! intramolecular transferase activity, transferring amino groups

[Term]
id: GO:0047703
name: beta-nitroacrylate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-nitropropanoate + NADP(+) = 3-nitroacrylate + H(+) + NADPH." [EC:1.3.1.16, RHEA:23895]
synonym: "3-nitropropanoate:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.16]
synonym: "b-nitroacrylate reductase activity" EXACT []
xref: EC:1.3.1.16
xref: KEGG:R03900
xref: MetaCyc:BETA-NITROACRYLATE-REDUCTASE-RXN
xref: RHEA:23895
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047704
name: bile-salt sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate." [EC:2.8.2.14, MetaCyc:BILE-SALT-SULFOTRANSFERASE-RXN]
subset: goslim_chembl
synonym: "3'-phosphoadenylyl-sulfate:glycolithocholate sulfotransferase activity" EXACT [EC:2.8.2.14]
synonym: "BAST I activity" NARROW [EC:2.8.2.14]
synonym: "bile acid sulfotransferase I activity" NARROW [EC:2.8.2.14]
synonym: "bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase activity" EXACT [EC:2.8.2.14]
synonym: "bile salt:3'phosphoadenosine-5'-phosphosulfate:sulfotransferase activity" EXACT [EC:2.8.2.14]
synonym: "bile-salt sulphotransferase activity" EXACT []
synonym: "glycolithocholate sulfotransferase activity" NARROW [EC:2.8.2.14]
xref: EC:2.8.2.14
xref: MetaCyc:BILE-SALT-SULFOTRANSFERASE-RXN
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0047705
name: bilirubin oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 bilirubin + O(2) = 2 biliverdin + 2 H(2)O." [EC:1.3.3.5, RHEA:20983]
synonym: "bilirubin oxidase M-1" RELATED [EC:1.3.3.5]
synonym: "bilirubin:oxygen oxidoreductase activity" EXACT [EC:1.3.3.5]
xref: EC:1.3.3.5
xref: KEGG:R02394
xref: MetaCyc:BILIRUBIN-OXIDASE-RXN
xref: RHEA:20983
is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor

[Term]
id: GO:0047706
name: biochanin-A reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: dihydrobiochanin A + NADP(+) = biochanin A + H(+) + NADPH." [EC:1.3.1.46, RHEA:12820]
synonym: "dihydrobiochanin-A:NADP+ delta2-oxidoreductase activity" EXACT [EC:1.3.1.46]
xref: EC:1.3.1.46
xref: KEGG:R02954
xref: MetaCyc:BIOCHANIN-A-REDUCTASE-RXN
xref: RHEA:12820
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047707
name: biotin-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + biotin + CoA = AMP + diphosphate + biotinyl-CoA." [EC:6.2.1.11, MetaCyc:BIOTIN--COA-LIGASE-RXN]
synonym: "biotin CoA synthetase activity" EXACT [EC:6.2.1.11]
synonym: "biotin:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.11]
synonym: "biotinyl coenzyme A synthetase activity" EXACT [EC:6.2.1.11]
synonym: "biotinyl-CoA synthetase activity" EXACT [EC:6.2.1.11]
xref: EC:6.2.1.11
xref: MetaCyc:BIOTIN--COA-LIGASE-RXN
xref: RHEA:19684
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0047708
name: biotinidase activity
namespace: molecular_function
def: "Catalysis of the reaction: biotin amide + H2O = biotin + NH3." [EC:3.5.1.12, MetaCyc:BIOTINIDASE-RXN]
synonym: "amidohydrolase biotinidase activity" EXACT [EC:3.5.1.12]
synonym: "biotin-amide amidohydrolase activity" EXACT [EC:3.5.1.12]
xref: EC:3.5.1.12
xref: MetaCyc:BIOTINIDASE-RXN
xref: RHEA:13084
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047709
name: bis(2-ethylhexyl)phthalate esterase activity
namespace: molecular_function
def: "Catalysis of the reaction: bis(2-ethylhexyl)phthalate + H(2)O = 2-ethylhexan-1-ol + 2-ethylhexyl phthalate + H(+)." [EC:3.1.1.60, RHEA:15532]
synonym: "bis(2-ethylhexyl)phthalate acylhydrolase activity" EXACT [EC:3.1.1.60]
synonym: "DEHP esterase activity" EXACT [EC:3.1.1.60]
xref: EC:3.1.1.60
xref: KEGG:R04202
xref: MetaCyc:BIS2-ETHYLHEXYLPHTHALATE-ESTERASE-RXN
xref: RHEA:15532
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0047710
name: bis(5'-adenosyl)-triphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: P(1),P(3)-bis(5'-adenosyl) triphosphate + H(2)O = ADP + AMP + 2 H(+)." [EC:3.6.1.29, RHEA:13896]
synonym: "1-P,3-P-bis(5'-adenosyl)-triphosphate adenylohydrolase activity" EXACT [EC:3.6.1.29]
synonym: "AP(3)A hydrolase activity" EXACT [EC:3.6.1.29]
synonym: "AP(3)Aase activity" EXACT [EC:3.6.1.29]
synonym: "AP3A hydrolase activity" EXACT [EC:3.6.1.29]
synonym: "AP3Aase activity" EXACT [EC:3.6.1.29]
synonym: "diadenosine 5',5'''-P(1),P(3)-triphosphate hydrolase activity" EXACT [EC:3.6.1.29]
synonym: "diadenosine 5',5'''-P1,P3-triphosphate hydrolase activity" EXACT [EC:3.6.1.29]
synonym: "diadenosine 5,5-P1,P3-triphosphatase activity" EXACT [EC:3.6.1.29]
synonym: "dinucleosidetriphosphatase activity" EXACT [EC:3.6.1.29]
synonym: "P1,P3-bis(5'-adenosyl)-triphosphate adenylohydrolase activity" EXACT [EC:3.6.1.29]
xref: EC:3.6.1.29
xref: KEGG:R00187
xref: MetaCyc:BIS5-ADENOSYL-TRIPHOSPHATASE-RXN
xref: RHEA:13896
is_a: GO:0004551 ! nucleotide diphosphatase activity

[Term]
id: GO:0047711
name: blasticidin-S deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: blasticidin S + H2O = deaminohydroxyblasticidin S + NH3." [EC:3.5.4.23, MetaCyc:BLASTICIDIN-S-DEAMINASE-RXN]
subset: gosubset_prok
synonym: "blasticidin-S aminohydrolase activity" EXACT [EC:3.5.4.23]
xref: EC:3.5.4.23
xref: MetaCyc:BLASTICIDIN-S-DEAMINASE-RXN
xref: RHEA:10151
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0047712
name: Cypridina-luciferin 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: Cypridina luciferin + O2 = oxidized Cypridina luciferin + CO2 + light." [EC:1.13.12.6, MetaCyc:CYPRIDINA-LUCIFERIN-2-MONOOXYGENASE-RXN]
synonym: "Cypridina luciferase activity" EXACT [EC:1.13.12.6]
synonym: "Cypridina-luciferin:oxygen 2-oxidoreductase (decarboxylating)" EXACT [EC:1.13.12.6]
synonym: "Cypridina-type luciferase activity" EXACT [EC:1.13.12.6]
synonym: "luciferase (Cypridina luciferin)" EXACT [EC:1.13.12.6]
synonym: "luciferase activity" BROAD [EC:1.13.12.6]
xref: EC:1.13.12.6
xref: MetaCyc:CYPRIDINA-LUCIFERIN-2-MONOOXYGENASE-RXN
xref: RHEA:22763
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)
is_a: GO:0045289 ! luciferin monooxygenase activity

[Term]
id: GO:0047713
name: galactitol 2-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: galactitol + NAD(+) = D-tagatose + H(+) + NADH." [EC:1.1.1.16, RHEA:20688]
xref: EC:1.1.1.16
xref: KEGG:R02928
xref: MetaCyc:GALACTITOL-2-DEHYDROGENASE-RXN
xref: RHEA:20688
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
is_a: GO:0031320 ! hexitol dehydrogenase activity

[Term]
id: GO:0047714
name: galactolipase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 carboxylates." [EC:3.1.1.26, MetaCyc:GALACTOLIPASE-RXN]
synonym: "1,2-diacyl-3-beta-D-galactosyl-sn-glycerol acylhydrolase activity" EXACT [EC:3.1.1.26]
synonym: "galactolipid acylhydrolase activity" EXACT [EC:3.1.1.26]
synonym: "galactolipid lipase activity" EXACT [EC:3.1.1.26]
synonym: "polygalactolipase activity" EXACT [EC:3.1.1.26]
xref: EC:3.1.1.26
xref: MetaCyc:GALACTOLIPASE-RXN
xref: RHEA:13192
is_a: GO:0016298 ! lipase activity
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0047715
name: hypotaurocyamine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + hypotaurocyamine = N(omega)-phosphohypotaurocyamine + ADP + 2 H(+)." [EC:2.7.3.6, RHEA:24011]
synonym: "ATP:hypotaurocyamine N-phosphotransferase activity" EXACT [EC:2.7.3.6]
xref: EC:2.7.3.6
xref: KEGG:R03939
xref: MetaCyc:HYPOTAUROCYAMINE-KINASE-RXN
xref: RHEA:24011
is_a: GO:0016301 ! kinase activity
is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor

[Term]
id: GO:0047716
name: imidazole N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1H-imidazole + acetyl-CoA = N-acetylimidazole + CoA." [EC:2.3.1.2, RHEA:15816]
synonym: "acetyl-CoA:imidazole N-acetyltransferase activity" EXACT [EC:2.3.1.2]
synonym: "imidazole acetylase activity" EXACT [EC:2.3.1.2]
synonym: "imidazole acetyltransferase activity" EXACT [EC:2.3.1.2]
xref: EC:2.3.1.2
xref: KEGG:R03621
xref: MetaCyc:IMIDAZOLE-N-ACETYLTRANSFERASE-RXN
xref: RHEA:15816
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0047717
name: imidazoleacetate 4-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(+) + imidazol-4-ylacetate + NADH + O(2) = 5-hydroxyimidazole-4-acetate + H(2)O + NAD(+)." [EC:1.14.13.5, RHEA:19428]
synonym: "4-imidazoleacetate,NADH:oxygen oxidoreductase (5-hydroxylating)" EXACT [EC:1.14.13.5]
synonym: "imidazoleacetate hydroxylase activity" EXACT [EC:1.14.13.5]
synonym: "imidazoleacetic hydroxylase activity" EXACT []
synonym: "imidazoleacetic monooxygenase activity" EXACT [EC:1.14.13.5]
xref: EC:1.14.13.5
xref: KEGG:R04066
xref: MetaCyc:IMIDAZOLEACETATE-4-MONOOXYGENASE-RXN
xref: RHEA:19428
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047718
name: indanol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: indan-1-ol + NAD(P)+ = indanone + NAD(P)H + H+." [EC:1.1.1.112, MetaCyc:INDANOL-DEHYDROGENASE-RXN]
synonym: "indan-1-ol:NAD(P)+ 1-oxidoreductase activity" EXACT [EC:1.1.1.112]
xref: EC:1.1.1.112
xref: MetaCyc:INDANOL-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047719
name: indole 2,3-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: indole + O(2) = 2-formamidobenzaldehyde." [EC:1.13.11.17, RHEA:11215]
synonym: "IDO" RELATED [EC:1.13.11.17]
synonym: "indole oxidase activity" EXACT [EC:1.13.11.17]
synonym: "indole-oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.17]
synonym: "indole:O2 oxidoreductase activity" EXACT [EC:1.13.11.17]
synonym: "indole:oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.17]
xref: EC:1.13.11.17
xref: KEGG:R02338
xref: MetaCyc:INDOLE-23-DIOXYGENASE-RXN
xref: RHEA:11215
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0047720
name: indoleacetaldoxime dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (indol-3-yl)acetaldehyde oxime = (indol-3-yl)acetonitrile + H(2)O." [EC:4.99.1.6, RHEA:23159]
synonym: "(indol-3-yl)acetaldehyde-oxime hydro-lyase [(indol-3-yl)acetonitrile-forming]" RELATED [EC:4.99.1.6]
synonym: "(indol-3-yl)acetaldehyde-oxime hydro-lyase activity" EXACT [EC:4.99.1.6]
synonym: "3-indoleacetaldoxime hydro-lyase activity" EXACT [EC:4.99.1.6]
synonym: "indole-3-acetaldehyde-oxime hydro-lyase activity" EXACT [EC:4.99.1.6]
synonym: "indole-3-acetaldoxime hydro-lyase activity" EXACT [EC:4.99.1.6]
synonym: "indoleacetaldoxime hydro-lyase activity" EXACT [EC:4.99.1.6]
xref: EC:4.99.1.6
xref: KEGG:R04093
xref: MetaCyc:RXN-1403
xref: RHEA:23159
is_a: GO:0016829 ! lyase activity

[Term]
id: GO:0047721
name: indoleacetate-lysine synthetase activity
namespace: molecular_function
def: "Catalysis of the reaction: (indol-3-yl)acetate + L-lysine + ATP = N(6)-[(indole-3-yl)acetyl]-L-lysine + ADP + 2 H(+) + phosphate." [EC:6.3.2.20, RHEA:14860]
subset: gosubset_prok
synonym: "(indol-3-yl)acetate:L-lysine ligase (ADP-forming)" EXACT [EC:6.3.2.20]
synonym: "IAA-lysine synthetase activity" EXACT [EC:6.3.2.20]
synonym: "indoleacetate-lysine ligase activity" EXACT []
synonym: "indoleacetate:L-lysine ligase (ADP-forming)" EXACT [EC:6.3.2.20]
synonym: "N-(indole-3-acetyl)-L-lysine synthetase activity" EXACT [EC:6.3.2.20]
xref: EC:6.3.2.20
xref: KEGG:R03095
xref: MetaCyc:INDOLEACETATE--LYSINE-LIGASE-RXN
xref: RHEA:14860
is_a: GO:0010279 ! indole-3-acetic acid amido synthetase activity

[Term]
id: GO:0047722
name: indolelactate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-(indol-3-yl)lactate + NAD(+) = 3-(indol-3-yl)pyruvate + H(+) + NADH." [EC:1.1.1.110, RHEA:20136]
synonym: "(indol-3-yl)lactate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.110]
synonym: "indole-3-lactate dehydrogenase activity" EXACT []
synonym: "indolelactate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.110]
xref: EC:1.1.1.110
xref: KEGG:R01971
xref: MetaCyc:INDOLELACTATE-DEHYDROGENASE-RXN
xref: RHEA:20136
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047723
name: inosinate nucleosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + IMP = D-ribose 5-phosphate + hypoxanthine." [EC:3.2.2.12, RHEA:20472]
synonym: "5'-inosinate phosphoribohydrolase activity" EXACT [EC:3.2.2.12]
xref: EC:3.2.2.12
xref: KEGG:R01128
xref: MetaCyc:INOSINATE-NUCLEOSIDASE-RXN
xref: RHEA:20472
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0047724
name: inosine nucleosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: inosine + H2O = D-ribose + hypoxanthine." [EC:3.2.2.2, MetaCyc:INOSINE-NUCLEOSIDASE-RXN]
synonym: "inosinase activity" EXACT [EC:3.2.2.2]
synonym: "inosine ribohydrolase activity" EXACT [EC:3.2.2.2]
synonym: "inosine-guanosine nucleosidase activity" EXACT [EC:3.2.2.2]
xref: EC:3.2.2.2
xref: MetaCyc:INOSINE-NUCLEOSIDASE-RXN
xref: RHEA:16660
is_a: GO:0008477 ! purine nucleosidase activity

[Term]
id: GO:0047725
name: inulosucrase activity
namespace: molecular_function
def: "Catalysis of the reaction: sucrose + 2,1-beta-D-fructosyl(n) = glucose + 2,1-beta-D-fructosyl(n+1)." [EC:2.4.1.9, MetaCyc:INULOSUCRASE-RXN]
subset: gosubset_prok
synonym: "sucrose 1-fructosyl transferase activity" EXACT [EC:2.4.1.9]
synonym: "sucrose 1-fructosyltransferase activity" EXACT [EC:2.4.1.9]
synonym: "sucrose:2,1-beta-D-fructan 1-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.9]
xref: EC:2.4.1.9
xref: MetaCyc:INULOSUCRASE-RXN
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0047726
name: iron-cytochrome-c reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: ferrocytochrome c + Fe3+ = ferricytochrome c + Fe2+." [EC:1.9.99.1, MetaCyc:IRON--CYTOCHROME-C-REDUCTASE-RXN]
synonym: "ferrocytochrome-c:Fe3+ oxidoreductase activity" EXACT [EC:1.9.99.1]
synonym: "iron-cytochrome c reductase activity" EXACT [EC:1.9.99.1]
xref: EC:1.9.99.1
xref: MetaCyc:IRON--CYTOCHROME-C-REDUCTASE-RXN
is_a: GO:0016675 ! oxidoreductase activity, acting on a heme group of donors

[Term]
id: GO:0047727
name: isobutyryl-CoA mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: isobutyryl-CoA = butanoyl-CoA." [EC:5.4.99.13, RHEA:13144]
subset: gosubset_prok
synonym: "2-methylpropanoyl-CoA CoA-carbonylmutase activity" EXACT [EC:5.4.99.13]
synonym: "butyryl-CoA:isobutyryl-CoA mutase activity" EXACT [EC:5.4.99.13]
synonym: "isobutyryl coenzyme A mutase activity" EXACT [EC:5.4.99.13]
xref: EC:5.4.99.13
xref: KEGG:R01181
xref: MetaCyc:ISOBUTYRYL-COA-MUTASE-RXN
xref: RHEA:13144
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0047728
name: carnitine 3-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: carnitine + NAD(+) = 3-dehydrocarnitine + H(+) + NADH." [EC:1.1.1.108, RHEA:19268]
subset: gosubset_prok
synonym: "carnitine:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.108]
xref: EC:1.1.1.108
xref: KEGG:R02395
xref: MetaCyc:CARNITINE-3-DEHYDROGENASE-RXN
xref: RHEA:19268
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047729
name: carnitine decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: carnitine + H(+) = 2-methylcholine + CO(2)." [EC:4.1.1.42, RHEA:21579]
synonym: "carnitine carboxy-lyase (2-methylcholine-forming)" EXACT [EC:4.1.1.42]
synonym: "carnitine carboxy-lyase activity" EXACT [EC:4.1.1.42]
xref: EC:4.1.1.42
xref: KEGG:R02398
xref: MetaCyc:CARNITINE-DECARBOXYLASE-RXN
xref: RHEA:21579
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047730
name: carnosine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-histidine + beta-alanine = AMP + diphosphate + carnosine." [EC:6.3.2.11, MetaCyc:CARNOSINE-SYNTHASE-RXN]
synonym: "carnosine synthetase activity" EXACT [EC:6.3.2.11]
synonym: "carnosine-anserine synthetase activity" EXACT [EC:6.3.2.11]
synonym: "carnosine-homocarnosine synthetase activity" EXACT [EC:6.3.2.11]
synonym: "homocarnosine-carnosine synthetase activity" EXACT [EC:6.3.2.11]
synonym: "L-histidine:beta-alanine ligase (AMP-forming)" EXACT [EC:6.3.2.11]
xref: EC:6.3.2.11
xref: MetaCyc:CARNOSINE-SYNTHASE-RXN
xref: RHEA:19300
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0047731
name: catechol oxidase (dimerizing) activity
namespace: molecular_function
def: "Catalysis of the reaction: 4 catechol + 3 O2 = 2 dibenzo[1,4]dioxin-2,3-dione + 6 H2O." [EC:1.1.3.14, MetaCyc:CATECHOL-OXIDASE-DIMERIZING-RXN]
synonym: "catechol:oxygen oxidoreductase (dimerizing)" EXACT [EC:1.1.3.14]
xref: EC:1.1.3.14
xref: MetaCyc:CATECHOL-OXIDASE-DIMERIZING-RXN
xref: RHEA:12812
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0047732
name: CDP-abequose epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: CDP-3,6-dideoxy-D-glucose = CDP-3,6-dideoxy-D-mannose." [EC:5.1.3.10, RHEA:21659]
synonym: "CDP-3,6-dideoxy-D-glucose 2-epimerase activity" EXACT [EC:5.1.3.10]
synonym: "CDP-D-abequose 2-epimerase activity" EXACT [EC:5.1.3.10]
synonym: "CDP-paratose 2-epimerase activity" EXACT [EC:5.1.3.10]
synonym: "CDP-paratose epimerase activity" EXACT [EC:5.1.3.10]
synonym: "CDP-tyvelose 2-epimerase activity" EXACT [EC:5.1.3.10]
synonym: "cytidine diphosphate paratose-2-epimerase activity" EXACT [EC:5.1.3.10]
synonym: "cytidine diphosphoabequose epimerase activity" EXACT [EC:5.1.3.10]
synonym: "cytidine diphosphodideoxyglucose epimerase activity" EXACT [EC:5.1.3.10]
synonym: "cytidine diphosphoparatose epimerase activity" EXACT [EC:5.1.3.10]
xref: EC:5.1.3.10
xref: KEGG:R04266
xref: MetaCyc:RXN-9160
xref: RHEA:21659
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0047733
name: CDP-glucose 4,6-dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: CDP-D-glucose = CDP-4-dehydro-6-deoxy-D-glucose + H(2)O." [EC:4.2.1.45, RHEA:17156]
subset: gosubset_prok
synonym: "CDP-glucose 4,6-hydro-lyase (CDP-4-dehydro-6-deoxy-D-glucose-forming)" EXACT [EC:4.2.1.45]
synonym: "CDP-glucose 4,6-hydro-lyase activity" EXACT [EC:4.2.1.45]
synonym: "CDPglucose 4,6-dehydratase activity" EXACT [EC:4.2.1.45]
synonym: "CDPglucose 4,6-hydro-lyase activity" EXACT [EC:4.2.1.45]
synonym: "cytidine diphosphoglucose oxidoreductase activity" EXACT [EC:4.2.1.45]
xref: EC:4.2.1.45
xref: KEGG:R02426
xref: MetaCyc:CDP-GLUCOSE-46-DEHYDRATASE-RXN
xref: RHEA:17156
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047734
name: CDP-glycerol diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: CDP-glycerol + H(2)O = sn-glycerol 3-phosphate + CMP + 2 H(+)." [EC:3.6.1.16, RHEA:21695]
synonym: "CDP-glycerol phosphoglycerohydrolase activity" EXACT [EC:3.6.1.16]
synonym: "CDP-glycerol pyrophosphatase activity" EXACT []
synonym: "CDPglycerol diphosphatase activity" EXACT [EC:3.6.1.16]
synonym: "CDPglycerol phosphoglycerohydrolase activity" EXACT [EC:3.6.1.16]
synonym: "CDPglycerol pyrophosphatase activity" EXACT [EC:3.6.1.16]
synonym: "cytidine diphosphoglycerol pyrophosphatase activity" EXACT [EC:3.6.1.16]
xref: EC:3.6.1.16
xref: KEGG:R00855
xref: MetaCyc:CDP-GLYCEROL-PYROPHOSPHATASE-RXN
xref: RHEA:21695
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0047735
name: cellobiose dehydrogenase (acceptor) activity
namespace: molecular_function
alt_id: GO:0047737
def: "Catalysis of the reaction: cellobiose + acceptor = cellobiono-1,5-lactone + reduced acceptor." [EC:1.1.99.18, MetaCyc:CELLOBIOSE-DEHYDROGENASE-ACCEPTOR-RXN]
synonym: "CBOR activity" RELATED [EC:1.1.99.18]
synonym: "CDH activity" RELATED [EC:1.1.99.18]
synonym: "cellobiose dehydrogenase (quinone) activity" NARROW [EC:1.1.99.18]
synonym: "cellobiose dehydrogenase activity" EXACT [EC:1.1.99.18]
synonym: "cellobiose oxidase activity" EXACT [EC:1.1.99.18]
synonym: "cellobiose oxidoreductase activity" EXACT [EC:1.1.99.18]
synonym: "cellobiose-quinone oxidoreductase activity" NARROW [EC:1.1.99.18]
synonym: "cellobiose:(acceptor) 1-oxidoreductase activity" EXACT [EC:1.1.99.18]
synonym: "cellobiose:acceptor 1-oxidoreductase activity" EXACT [EC:1.1.99.18]
synonym: "cellobiose:oxygen 1-oxidoreductase activity" EXACT [EC:1.1.99.18]
synonym: "phanerochaete chrysosporium cellobiose oxidoreductase activity" EXACT [EC:1.1.99.18]
xref: EC:1.1.99.18
xref: MetaCyc:CELLOBIOSE-DEHYDROGENASE-ACCEPTOR-RXN
xref: RHEA:23487
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0047736
name: cellobiose epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: cellobiose = D-glucosyl-D-mannose." [EC:5.1.3.11, MetaCyc:CELLOBIOSE-EPIMERASE-RXN]
synonym: "cellobiose 2-epimerase activity" EXACT [EC:5.1.3.11]
xref: EC:5.1.3.11
xref: MetaCyc:CELLOBIOSE-EPIMERASE-RXN
xref: RHEA:23387
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0047738
name: cellobiose phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: cellobiose + phosphate = alpha-D-glucose 1-phosphate + D-glucose." [EC:2.4.1.20, MetaCyc:CELLOBIOSE-PHOSPHORYLASE-RXN]
subset: gosubset_prok
synonym: "cellobiose:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.20]
xref: EC:2.4.1.20
xref: MetaCyc:CELLOBIOSE-PHOSPHORYLASE-RXN
xref: RHEA:19496
is_a: GO:0004645 ! phosphorylase activity

[Term]
id: GO:0047739
name: cephalosporin-C deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: cephalosporin C + H(2)O = acetate + deacetylcephalosporin C + H(+)." [EC:3.1.1.41, RHEA:22599]
subset: gosubset_prok
synonym: "cephalosporin acetylesterase activity" EXACT [EC:3.1.1.41]
synonym: "cephalosporin C acetyl-esterase activity" EXACT [EC:3.1.1.41]
synonym: "cephalosporin C acetyl-hydrolase activity" EXACT [EC:3.1.1.41]
synonym: "cephalosporin C acetylase activity" EXACT [EC:3.1.1.41]
synonym: "cephalosporin C acetylesterase activity" EXACT [EC:3.1.1.41]
synonym: "cephalosporin C deacetylase activity" EXACT [EC:3.1.1.41]
synonym: "cephalosporin-C acetylhydrolase activity" EXACT [EC:3.1.1.41]
xref: EC:3.1.1.41
xref: KEGG:R03062
xref: MetaCyc:CEPHALOSPORIN-C-DEACETYLASE-RXN
xref: RHEA:22599
is_a: GO:0019213 ! deacetylase activity
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0047740
name: cephalosporin-C transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: (7R)-7-(5-carboxylato-5-oxopentanamido)deacetylcephalosporanate + D-glutamate = 2-oxoglutarate + cephalosporin C." [EC:2.6.1.74, RHEA:14556]
synonym: "cephalosporin C aminotransferase activity" EXACT [EC:2.6.1.74]
synonym: "cephalosporin-C:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.74]
synonym: "L-alanine:cephalosporin-C aminotransferase activity" EXACT [EC:2.6.1.74]
xref: EC:2.6.1.74
xref: KEGG:R03063
xref: MetaCyc:CEPHALOSPORIN-C-TRANSAMINASE-RXN
xref: RHEA:14556
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047741
name: cetraxate benzylesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzyl cetraxate + H(2)O = benzyl alcohol + cetraxate + H(+)." [EC:3.1.1.70, RHEA:23463]
synonym: "cetraxate-benzyl-ester benzylhydrolase activity" EXACT [EC:3.1.1.70]
xref: EC:3.1.1.70
xref: KEGG:R03612
xref: MetaCyc:CETRAXATE-BENZYLESTERASE-RXN
xref: RHEA:23463
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0047742
name: chenodeoxycholoyltaurine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: chenodeoxycholoyltaurine + H2O = chenodeoxycholate + taurine." [EC:3.5.1.74, MetaCyc:CHENODEOXYCHOLOYLTAURINE-HYDROLASE-RXN]
synonym: "chenodeoxycholoyltaurine amidohydrolase activity" EXACT [EC:3.5.1.74]
xref: EC:3.5.1.74
xref: MetaCyc:CHENODEOXYCHOLOYLTAURINE-HYDROLASE-RXN
xref: RHEA:16312
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047743
name: chlordecone reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: chlordecone alcohol + NADP(+) = chlordecone + H(+) + NADPH." [EC:1.1.1.225, RHEA:14404]
synonym: "CDR activity" RELATED [EC:1.1.1.225]
synonym: "chlordecone-alcohol:NADP+ 2-oxidoreductase activity" EXACT [EC:1.1.1.225]
xref: EC:1.1.1.225
xref: KEGG:R03716
xref: MetaCyc:CHLORDECONE-REDUCTASE-RXN
xref: RHEA:14404
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047744
name: chloridazon-catechol dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-amino-4-chloro-2-(2,3-dihydroxyphenyl)pyridazin-3(2H)-one + O(2) = 5-amino-4-chloro-2-(2-hydroxymuconoyl)pyridazin-3(2H)-one + 2 H(+)." [EC:1.13.11.36, RHEA:20452]
synonym: "5-amino-4-chloro-2-(2,3-dihydroxyphenyl)-3(2H)-pyridazinone 1,2-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.36]
xref: EC:1.13.11.36
xref: KEGG:R04602
xref: MetaCyc:CHLORIDAZON-CATECHOL-DIOXYGENASE-RXN
xref: RHEA:20452
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0047745
name: chlorogenate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: chlorogenate + H(2)O = (-)-quinate + cis-caffeate + H(+)." [EC:3.1.1.42, RHEA:20692]
synonym: "chlorogenase activity" EXACT [EC:3.1.1.42]
synonym: "chlorogenic acid esterase activity" EXACT [EC:3.1.1.42]
xref: EC:3.1.1.42
xref: KEGG:R02997
xref: MetaCyc:CHLOROGENATE-HYDROLASE-RXN
xref: RHEA:20692
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0047746
name: chlorophyllase activity
namespace: molecular_function
def: "Catalysis of the reaction: chlorophyll + H2O = phytol + chlorophyllide." [EC:3.1.1.14, MetaCyc:CHLOROPHYLLASE-RXN]
synonym: "chlorophyll chlorophyllidohydrolase activity" EXACT [EC:3.1.1.14]
xref: EC:3.1.1.14
xref: MetaCyc:CHLOROPHYLLASE-RXN
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0047747
name: cholate-CoA ligase activity
namespace: molecular_function
alt_id: GO:0047477
def: "Catalysis of the reactions: (1) ATP + cholate + CoA = AMP + diphosphate + choloyl-CoA and (2) ATP + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA = AMP + diphosphate + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA." [EC:6.2.1.7, MetaCyc:CHOLATE--COA-LIGASE-RXN]
synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate--CoA ligase activity" EXACT [EC:6.2.1.29]
synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate-CoA ligase activity" EXACT []
synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate:CoA ligase (AMP-forming) activity" EXACT [EC:6.2.1.29]
synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoate-CoA ligase activity" EXACT [EC:6.2.1.29]
synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoate-CoA synthetase activity" EXACT [EC:6.2.1.29]
synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl coenzyme A synthetase activity" EXACT [EC:6.2.1.29]
synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate-CoA ligase activity" EXACT [EC:6.2.1.29]
synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.29]
synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA ligase activity" EXACT [EC:6.2.1.29]
synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA synthetase activity" EXACT [EC:6.2.1.29]
synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl coenzyme A synthetase activity" EXACT [EC:6.2.1.29]
synonym: "BAL activity" RELATED [EC:6.2.1.29]
synonym: "bile acid CoA ligase activity" RELATED [EC:6.2.1.29]
synonym: "bile acid coenzyme A ligase activity" RELATED [EC:6.2.1.29]
synonym: "cholate thiokinase activity" EXACT [EC:6.2.1.29]
synonym: "cholate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.29]
synonym: "cholic acid:CoA ligase activity" EXACT [EC:6.2.1.29]
synonym: "cholic thiokinase activity" EXACT [EC:6.2.1.29]
synonym: "choloyl coenzyme A synthetase activity" EXACT [EC:6.2.1.29]
synonym: "choloyl-CoA synthetase activity" EXACT [EC:6.2.1.29]
synonym: "cholyl-CoA synthetase activity" EXACT [EC:6.2.1.29]
synonym: "THCA-CoA ligase activity" RELATED [EC:6.2.1.29]
synonym: "trihydroxycoprostanoyl-CoA synthetase activity" RELATED [EC:6.2.1.29]
xref: EC:6.2.1.7
xref: MetaCyc:CHOLATE--COA-LIGASE-RXN
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0047748
name: cholestanetetraol 26-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-beta-cholestane-3-alpha,7-alpha,12-alpha,26-tetraol + NAD+ = 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-al + NADH." [EC:1.1.1.161, MetaCyc:CHOLESTANETETRAOL-26-DEHYDROGENASE-RXN]
synonym: "5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol:NAD+ 26-oxidoreductase activity" EXACT [EC:1.1.1.161]
synonym: "5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol dehydrogenase activity" EXACT [EC:1.1.1.161]
synonym: "cholestanetetrol 26-dehydrogenase activity" EXACT [EC:1.1.1.161]
synonym: "TEHC-NAD oxidoreductase activity" EXACT [EC:1.1.1.161]
xref: EC:1.1.1.161
xref: MetaCyc:CHOLESTANETETRAOL-26-DEHYDROGENASE-RXN
xref: RHEA:12395
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047749
name: cholestanetriol 26-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol + NADPH + O2 = 5-beta-cholestane-3-alpha,7-alpha,12-alpha,26-tetraol + NADP+ + H2O." [EC:1.14.13.15, MetaCyc:CHOLESTANETRIOL-26-MONOOXYGENASE-RXN]
synonym: "5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 26-hydroxylase activity" EXACT [EC:1.14.13.15]
synonym: "5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol hydroxylase activity" BROAD [EC:1.14.13.15]
synonym: "5beta-cholestane-3alpha,7alpha,12alpha-triol 26-hydroxylase activity" EXACT [EC:1.14.13.15]
synonym: "5beta-cholestane-3alpha,7alpha,12alpha-triol hydroxylase activity" EXACT [EC:1.14.13.15]
synonym: "5beta-cholestane-3alpha,7alpha,12alpha-triol,NADPH:oxygen oxidoreductase (26-hydroxylating)" EXACT [EC:1.14.13.15]
synonym: "cholestanetriol 26-hydroxylase activity" EXACT []
synonym: "cholesterol 27-hydroxylase activity" RELATED [EC:1.14.13.15]
synonym: "CYP27A" RELATED [EC:1.14.13.15]
synonym: "CYP27A1" RELATED [EC:1.14.13.15]
synonym: "cytochrome P450 27A1' activity" NARROW [EC:1.14.13.15]
synonym: "sterol 26-hydroxylase activity" BROAD [EC:1.14.13.15]
synonym: "sterol 27-hydroxylase activity" RELATED [EC:1.14.13.15]
xref: EC:1.14.13.15
xref: MetaCyc:CHOLESTANETRIOL-26-MONOOXYGENASE-RXN
xref: RHEA:14376
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047750
name: cholestenol delta-isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-alpha-cholest-7-en-3-beta-ol = 5-alpha-cholest-8-en-3-beta-ol." [EC:5.3.3.5, MetaCyc:CHOLESTENOL-DELTA-ISOMERASE-RXN]
synonym: "cholestenol D-isomerase activity" EXACT []
synonym: "delta7-cholestenol delta7-delta8-isomerase activity" EXACT [EC:5.3.3.5]
xref: EC:5.3.3.5
xref: MetaCyc:RXN66-25
xref: RHEA:15284
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0047751
name: cholestenone 5-alpha-reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5alpha-cholestan-3-one + NADP(+) = cholest-4-en-3-one + H(+) + NADPH." [EC:1.3.1.22, RHEA:24555]
synonym: "3-oxo-5alpha-steroid:NADP+ delta4-oxidoreductase activity" EXACT [EC:1.3.1.22]
synonym: "3-oxosteroid 5alpha-reductase activity" EXACT [EC:1.3.1.22]
synonym: "3-oxosteroid delta4-dehydrogenase" BROAD [EC:1.3.1.22]
synonym: "4-ene-3-oxosteroid 5alpha-reductase activity" EXACT [EC:1.3.1.22]
synonym: "4-ene-5alpha-reductase activity" EXACT [EC:1.3.1.22]
synonym: "5alpha-reductase" BROAD [EC:1.3.1.22]
synonym: "cholest-4-en-3-one 5alpha-reductase activity" EXACT [EC:1.3.1.22]
synonym: "cholestenone 5a-reductase activity" EXACT []
synonym: "cholestenone 5alpha-reductase activity" EXACT [EC:1.3.1.22]
synonym: "delta4-3-ketosteroid 5alpha-oxidoreductase activity" EXACT [EC:1.3.1.22]
synonym: "reduced nicotinamide adenine dinucleotide phosphate:Delta4-3-ketosteroid 5alpha-oxidoreductase activity" EXACT [EC:1.3.1.22]
synonym: "steroid 5alpha-hydrogenase activity" EXACT [EC:1.3.1.22]
synonym: "steroid 5alpha-reductase" BROAD [EC:1.3.1.22]
synonym: "testosterone 5alpha-reductase" BROAD [EC:1.3.1.22]
synonym: "testosterone delta4-5alpha-reductase activity" EXACT [EC:1.3.1.22]
synonym: "testosterone delta4-hydrogenase activity" EXACT [EC:1.3.1.22]
xref: EC:1.3.1.22
xref: KEGG:R02610
xref: MetaCyc:CHOLESTENONE-5-ALPHA-REDUCTASE-RXN
xref: RHEA:24555
is_a: GO:0035671 ! enone reductase activity

[Term]
id: GO:0047753
name: choline-sulfatase activity
namespace: molecular_function
def: "Catalysis of the reaction: choline sulfate + H(2)O = choline + H(+) + sulfate." [EC:3.1.6.6, RHEA:20823]
subset: gosubset_prok
synonym: "choline-sulfate sulfohydrolase activity" EXACT [EC:3.1.6.6]
synonym: "choline-sulphatase activity" EXACT []
xref: EC:3.1.6.6
xref: KEGG:R01028
xref: MetaCyc:CHOLINE-SULFATASE-RXN
xref: RHEA:20823
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0047754
name: choline sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + choline = adenosine 3',5'-diphosphate + choline sulfate + H(+)." [EC:2.8.2.6, RHEA:21987]
synonym: "3'-phosphoadenylyl-sulfate:choline sulfotransferase activity" EXACT [EC:2.8.2.6]
synonym: "choline sulphokinase activity" EXACT [EC:2.8.2.6]
synonym: "choline sulphotransferase activity" EXACT []
xref: EC:2.8.2.6
xref: KEGG:R01027
xref: MetaCyc:CHOLINE-SULFOTRANSFERASE-RXN
xref: RHEA:21987
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0047755
name: isocitrate epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-threo-isocitrate = D-erythro-isocitrate." [EC:5.1.2.6, RHEA:10823]
synonym: "(1R,2S)-1-hydroxypropane-1,2,3-tricarboxylate 1-epimerase activity" EXACT [EC:5.1.2.6]
xref: EC:5.1.2.6
xref: KEGG:R02318
xref: MetaCyc:ISOCITRATE-EPIMERASE-RXN
xref: RHEA:10823
is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives

[Term]
id: GO:0047756
name: chondroitin 4-sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate." [EC:2.8.2.5, MetaCyc:CHONDROITIN-4-SULFOTRANSFERASE-RXN]
synonym: "3'-phosphoadenylyl-sulfate:chondroitin 4'-sulfotransferase activity" EXACT [EC:2.8.2.5]
synonym: "chondroitin 4-sulphotransferase activity" EXACT []
xref: EC:2.8.2.5
xref: MetaCyc:CHONDROITIN-4-SULFOTRANSFERASE-RXN
is_a: GO:0034481 ! chondroitin sulfotransferase activity

[Term]
id: GO:0047757
name: chondroitin-glucuronate 5-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: chondroitin D-glucuronate = dermatan L-iduronate." [EC:5.1.3.19, MetaCyc:CHONDROITIN-GLUCURONATE-5-EPIMERASE-RXN]
synonym: "chondroitin D-glucuronosyl 5-epimerase activity" EXACT [EC:5.1.3.19]
synonym: "chondroitin-D-glucuronate 5-epimerase activity" EXACT [EC:5.1.3.19]
synonym: "dermatan-sulfate 5-epimerase activity" EXACT [EC:5.1.3.19]
synonym: "polyglucuronate 5-epimerase activity" RELATED [EC:5.1.3.19]
synonym: "urunosyl C-5 epimerase activity" EXACT [EC:5.1.3.19]
xref: EC:5.1.3.19
xref: MetaCyc:CHONDROITIN-GLUCURONATE-5-EPIMERASE-RXN
xref: RHEA:21087
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0047758
name: ATP:2-methylpropanoate phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-methylpropanoate + ATP = 2-methylpropanoyl phosphate + ADP + H(+)." [EC:2.7.2.14, RHEA:24159]
synonym: "ATP:2-methylpropanoate 1-phosphotransferase activity" EXACT []
synonym: "ATP:2-methylpropanoate kinase activity" EXACT []
synonym: "ATP:branched-chain-fatty-acid 1-phosphotransferase activity" BROAD [EC:2.7.2.14, KEGG:R04002]
synonym: "ATP:isobutyrate 1-phosphotransferase activity" EXACT []
synonym: "branched-chain fatty acid kinase activity" BROAD [EC:2.7.2.14]
synonym: "branched-chain-fatty-acid kinase activity" BROAD [EC:2.7.2.14]
synonym: "isobutyrate kinase activity" BROAD [EC:2.7.2.14]
xref: EC:2.7.2.14
xref: KEGG:R04002
xref: MetaCyc:BRANCHED-CHAIN-FATTY-ACID-KINASE-RXN
xref: RHEA:24159
is_a: GO:0016301 ! kinase activity
is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor

[Term]
id: GO:0047759
name: butanal dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: butanal + CoA + NAD(P)+ = butanoyl-CoA + NAD(P)H + H+." [EC:1.2.1.57, MetaCyc:BUTANAL-DEHYDROGENASE-RXN]
synonym: "butanal:NAD(P)+ oxidoreductase (CoA-acylating)" EXACT [EC:1.2.1.57]
xref: EC:1.2.1.57
xref: MetaCyc:BUTANAL-DEHYDROGENASE-RXN
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047760
name: butyrate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + an acid + CoA = AMP + diphosphate + an acyl-CoA." [EC:6.2.1.2, MetaCyc:BUTYRATE--COA-LIGASE-RXN]
synonym: "acyl-activating enzyme activity" RELATED [EC:6.2.1.2]
synonym: "butanoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.2]
synonym: "butyryl-CoA synthetase activity" EXACT [EC:6.2.1.2]
synonym: "butyryl-coenzyme A synthetase activity" EXACT [EC:6.2.1.2]
synonym: "fatty acid activating enzyme" RELATED [EC:6.2.1.2]
synonym: "fatty acid thiokinase (medium chain) activity" RELATED [EC:6.2.1.2]
synonym: "fatty acyl coenzyme A synthetase activity" EXACT [EC:6.2.1.2]
synonym: "L-(+)-3-hydroxybutyryl CoA ligase activity" EXACT [EC:6.2.1.2]
synonym: "medium chain acyl-CoA synthetase activity" EXACT [EC:6.2.1.2]
synonym: "short-chain acyl-CoA synthetase activity" EXACT [EC:6.2.1.2]
xref: EC:6.2.1.2
xref: MetaCyc:BUTYRATE--COA-LIGASE-RXN
xref: RHEA:24339
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0047761
name: butyrate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + butanoate = ADP + butanoyl phosphate + H(+)." [EC:2.7.2.7, RHEA:13588]
subset: gosubset_prok
synonym: "ATP:butanoate 1-phosphotransferase activity" EXACT [EC:2.7.2.7]
xref: EC:2.7.2.7
xref: KEGG:R01688
xref: MetaCyc:BUTYRATE-KINASE-RXN
xref: RHEA:13588
is_a: GO:0016301 ! kinase activity
is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor

[Term]
id: GO:0047762
name: caffeate 3,4-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-caffeate + O(2) = 3-(2-carboxyethenyl)-cis,cis-muconate + 2 H(+)." [EC:1.13.11.22, RHEA:22219]
synonym: "3,4-dihydroxy-trans-cinnamate:oxygen 3,4-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.22]
xref: EC:1.13.11.22
xref: KEGG:R03365
xref: MetaCyc:CAFFEATE-34-DIOXYGENASE-RXN
xref: RHEA:22219
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0047763
name: caffeate O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3,4-dihydroxy-trans-cinnamate = S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-trans-cinnamate." [EC:2.1.1.68, MetaCyc:CAFFEATE-O-METHYLTRANSFERASE-RXN]
synonym: "caffeate 3-O-methyltransferase activity" EXACT [EC:2.1.1.68]
synonym: "caffeate methyltransferase activity" EXACT [EC:2.1.1.68]
synonym: "S-adenosyl-L-methionine:3,4-dihydroxy-trans-cinnamate 3-O-methyltransferase activity" EXACT [EC:2.1.1.68]
synonym: "S-adenosyl-L-methionine:caffeic acid-O-methyltransferase activity" EXACT [EC:2.1.1.68]
xref: EC:2.1.1.68
xref: MetaCyc:RXN-1104
xref: RHEA:20228
is_a: GO:0008171 ! O-methyltransferase activity

[Term]
id: GO:0047764
name: caldesmon kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + caldesmon = ADP + caldesmon phosphate." [GOC:curators]
xref: MetaCyc:2.7.11.17-RXN
is_a: GO:0004672 ! protein kinase activity

[Term]
id: GO:0047765
name: caldesmon-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: caldesmon phosphate + H2O = caldesmon + phosphate." [EC:3.1.3.55, MetaCyc:CALDESMON-PHOSPHATASE-RXN]
synonym: "caldesmon-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.55]
synonym: "smooth muscle caldesmon phosphatase activity" EXACT [EC:3.1.3.55]
synonym: "SMP-I" RELATED [EC:3.1.3.55]
xref: EC:3.1.3.55
xref: MetaCyc:CALDESMON-PHOSPHATASE-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0047766
name: carbamoyl-serine ammonia-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: O-carbamoyl-L-serine + H(2)O + H(+) = CO(2) + 2 NH(4)(+) + pyruvate." [EC:4.3.1.13, RHEA:15448]
synonym: "carbamoylserine deaminase activity" EXACT [EC:4.3.1.13]
synonym: "O-carbamoyl-L-serine ammonia-lyase (decarboxylating; pyruvate-forming)" EXACT [EC:4.3.1.13]
synonym: "O-carbamoyl-L-serine ammonia-lyase (pyruvate-forming)" EXACT [EC:4.3.1.13]
synonym: "O-carbamoyl-L-serine deaminase activity" EXACT [EC:4.3.1.13]
xref: EC:4.3.1.13
xref: KEGG:R00213
xref: MetaCyc:CARBAMOYL-SERINE-AMMONIA-LYASE-RXN
xref: RHEA:15448
is_a: GO:0016841 ! ammonia-lyase activity

[Term]
id: GO:0047768
name: carboxy-cis,cis-muconate cyclase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 3-carboxy-cis,cis-muconate." [EC:5.5.1.5, RHEA:14980]
synonym: "3-carboxy-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)" EXACT [EC:5.5.1.5]
synonym: "3-carboxy-cis,cis-muconate lactonizing enzyme activity" EXACT [EC:5.5.1.5]
synonym: "3-carboxymuconate cyclase activity" EXACT [EC:5.5.1.5]
xref: EC:5.5.1.5
xref: KEGG:R03308
xref: MetaCyc:CARBOXY-CISCIS-MUCONATE-CYCLASE-RXN
xref: RHEA:14980
is_a: GO:0009975 ! cyclase activity
is_a: GO:0016872 ! intramolecular lyase activity

[Term]
id: GO:0047769
name: arogenate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arogenate = L-phenylalanine + H2O + CO2." [EC:4.2.1.91, MetaCyc:CARBOXYCYCLOHEXADIENYL-DEHYDRATASE-RXN]
subset: gosubset_prok
synonym: "carboxycyclohexadienyl dehydratase activity" EXACT []
synonym: "L-arogenate hydro-lyase (decarboxylating)" EXACT [EC:4.2.1.91]
synonym: "L-arogenate hydro-lyase (decarboxylating; L-phenylalanine-forming)" EXACT [EC:4.2.1.91]
xref: EC:4.2.1.91
xref: MetaCyc:CARBOXYCYCLOHEXADIENYL-DEHYDRATASE-RXN
xref: RHEA:12539
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047770
name: carboxylate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: an aldehyde + acceptor + H2O = a carboxylate + reduced acceptor." [EC:1.2.99.6, MetaCyc:CARBOXYLATE-REDUCTASE-RXN]
synonym: "aldehyde:(acceptor) oxidoreductase activity" EXACT [EC:1.2.99.6]
synonym: "aldehyde:acceptor oxidoreductase activity" EXACT [EC:1.2.99.6]
synonym: "carboxylic acid reductase activity" EXACT [EC:1.2.99.6]
xref: EC:1.2.99.6
xref: MetaCyc:CARBOXYLATE-REDUCTASE-RXN
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0047771
name: carboxymethylhydantoinase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-5-carboxymethylhydantoin + H(2)O = N-carbamoyl-L-aspartate + H(+)." [EC:3.5.2.4, RHEA:12031]
synonym: "hydantoin hydrolase activity" EXACT [EC:3.5.2.4]
synonym: "L-5-carboxymethylhydantoin amidohydrolase activity" EXACT [EC:3.5.2.4]
xref: EC:3.5.2.4
xref: KEGG:R02284
xref: MetaCyc:CARBOXYMETHYLHYDANTOINASE-RXN
xref: RHEA:12031
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0047772
name: carboxymethyloxysuccinate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: carboxymethoxysuccinate = fumarate + glycolate." [EC:4.2.99.12, RHEA:12339]
synonym: "carboxymethyloxysuccinate glycolate-lyase (fumarate-forming)" EXACT [EC:4.2.99.12]
synonym: "carboxymethyloxysuccinate glycolate-lyase activity" EXACT [EC:4.2.99.12]
xref: EC:4.2.99.12
xref: KEGG:R01336
xref: MetaCyc:CARBOXYMETHYLOXYSUCCINATE-LYASE-RXN
xref: RHEA:12339
is_a: GO:0016835 ! carbon-oxygen lyase activity

[Term]
id: GO:0047773
name: carnitinamidase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-carnitinamide + H(2)O = (R)-carnitine + NH(4)(+)." [EC:3.5.1.73, RHEA:17540]
synonym: "carnitine amidase activity" EXACT [EC:3.5.1.73]
synonym: "L-carnitinamidase activity" EXACT [EC:3.5.1.73]
synonym: "L-carnitinamide amidohydrolase activity" EXACT [EC:3.5.1.73]
synonym: "L-carnitine amidase activity" EXACT [EC:3.5.1.73]
xref: EC:3.5.1.73
xref: KEGG:R01922
xref: MetaCyc:CARNITINAMIDASE-RXN
xref: RHEA:17540
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047774
name: cis-2-enoyl-CoA reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + NADP+ = cis-2,3-dehydroacyl-CoA + NADPH." [EC:1.3.1.37, MetaCyc:CIS-2-ENOYL-COA-REDUCTASE-NADPH-RXN]
synonym: "acyl-CoA:NADP+ cis-2-oxidoreductase activity" EXACT [EC:1.3.1.37]
synonym: "cis-2-enoyl-coenzyme A reductase activity" EXACT [EC:1.3.1.37]
synonym: "NADPH-dependent cis-enoyl-CoA reductase activity" EXACT [EC:1.3.1.37]
synonym: "reductase, cis-2-enoyl coenzyme A" EXACT [EC:1.3.1.37]
xref: EC:1.3.1.37
xref: MetaCyc:CIS-2-ENOYL-COA-REDUCTASE-NADPH-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047775
name: citramalate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + citramalate = acetate + (3S)-citramalyl-CoA." [EC:2.8.3.11, MetaCyc:CITRAMALATE-COA-TRANSFERASE-RXN]
synonym: "acetyl-CoA:citramalate CoA-transferase activity" EXACT [EC:2.8.3.11]
xref: EC:2.8.3.11
xref: MetaCyc:CITRAMALATE-COA-TRANSFERASE-RXN
xref: RHEA:17624
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0047776
name: citramalate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-citramalate = acetate + pyruvate." [EC:4.1.3.22, RHEA:15548]
synonym: "(+)-citramalate pyruvate-lyase activity" EXACT [EC:4.1.3.22]
synonym: "(3S)-citramalate pyruvate-lyase (acetate-forming)" EXACT [EC:4.1.3.22]
synonym: "(3S)-citramalate pyruvate-lyase activity" EXACT [EC:4.1.3.22]
synonym: "(S)-citramalate lyase activity" EXACT [EC:4.1.3.22]
synonym: "citramalate pyruvate lyase activity" EXACT [EC:4.1.3.22]
synonym: "citramalate pyruvate-lyase activity" EXACT [EC:4.1.3.22]
synonym: "citramalate synthetase activity" EXACT [EC:4.1.3.22]
synonym: "citramalic synthase activity" EXACT [EC:4.1.3.22]
synonym: "citramalic-condensing enzyme" RELATED [EC:4.1.3.22]
xref: EC:4.1.3.22
xref: KEGG:R00325
xref: MetaCyc:CITRAMALATE-LYASE-RXN
xref: RHEA:15548
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0047777
name: (3S)-citramalyl-CoA lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3S)-citramalyl-CoA = acetyl-CoA + pyruvate." [EC:4.1.3.25, RHEA:22615]
synonym: "(+)-CMA-CoA lyase activity" EXACT [EC:4.1.3.25]
synonym: "(3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)" EXACT [EC:4.1.3.25]
synonym: "(3S)-citramalyl-CoA pyruvate-lyase activity" EXACT [EC:4.1.3.25]
synonym: "citramalyl coenzyme A lyase activity" EXACT [EC:4.1.3.25]
synonym: "citramalyl-CoA lyase activity" BROAD []
xref: EC:4.1.3.25
xref: KEGG:R00237
xref: MetaCyc:CITRAMALYL-COA-LYASE-RXN
xref: RHEA:22615
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0047778
name: [citrate-(pro-3S)-lyase] thiolesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: [citrate (pro-3S)-lyase](acetyl form) + H2O = [citrate (pro-3S)-lyase](thiol form) + acetate." [EC:3.1.2.16, MetaCyc:CITRATE-PRO-3S-LYASE-THIOLESTERASE-RXN]
synonym: "[citrate-(pro-3S)-lyase] thioesterase activity" EXACT [EC:3.1.2.16]
synonym: "citrate (pro-3S)-lyase thiolesterase activity" EXACT []
synonym: "citrate lyase deacetylase activity" EXACT [EC:3.1.2.16]
synonym: "citrate-(pro-3S)-lyase thioesterase activity" EXACT [EC:3.1.2.16]
synonym: "citrate-(pro-3S)-lyase thiolesterase activity" EXACT [EC:3.1.2.16]
synonym: "citrate-(pro-3S)-lyase(acetyl-form) hydrolase activity" EXACT [EC:3.1.2.16]
xref: EC:3.1.2.16
xref: MetaCyc:CITRATE-PRO-3S-LYASE-THIOLESTERASE-RXN
is_a: GO:0016790 ! thiolester hydrolase activity

[Term]
id: GO:0047779
name: citrate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + citrate + CoA = (3S)-citryl-CoA + ADP + H(+) + phosphate." [EC:6.2.1.18, RHEA:21475]
synonym: "citrate thiokinase activity" EXACT [EC:6.2.1.18]
synonym: "citrate:CoA ligase (ADP-forming)" EXACT [EC:6.2.1.18]
synonym: "citrate:CoA ligase activity" EXACT [EC:6.2.1.18]
synonym: "citryl-CoA synthetase activity" EXACT [EC:6.2.1.18]
xref: EC:6.2.1.18
xref: KEGG:R01322
xref: MetaCyc:CITRATE--COA-LIGASE-RXN
xref: RHEA:21475
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0047780
name: citrate dehydratase activity
namespace: molecular_function
alt_id: GO:0052632
def: "Catalysis of the reaction: citrate = cis-aconitate + H2O." [EC:4.2.1.4]
comment: This term is also a sub-reaction of 'aconitate hydratase activity ; GO:0003994 (EC:4.2.1.3)'.
synonym: "aconitate hydratase activity" BROAD [EC:4.2.1.3]
synonym: "citrate hydro-lyase (cis-aconitate-forming)" EXACT [EC:4.2.1.4]
synonym: "citrate hydro-lyase (cis-aconitate-forming) activity" EXACT []
synonym: "citrate hydro-lyase activity" BROAD [EC:4.2.1.3, EC:4.2.1.4]
xref: EC:4.2.1.4
xref: KEGG:R01325
xref: MetaCyc:ACONITATEDEHYDR-RXN
xref: MetaCyc:CITRATE-DEHYDRATASE-RXN
xref: RHEA:10231
is_a: GO:0016836 ! hydro-lyase activity
relationship: has_part GO:0003994 ! aconitate hydratase activity

[Term]
id: GO:0047781
name: citrullinase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + citrulline = NH3 + CO2 + L-ornithine." [EC:3.5.1.20, MetaCyc:CITRULLINASE-RXN]
synonym: "citrulline hydrolase activity" EXACT [EC:3.5.1.20]
synonym: "citrulline ureidase activity" EXACT [EC:3.5.1.20]
synonym: "L-citrulline 5-N-carbamoyldihydrolase activity" EXACT [EC:3.5.1.20]
synonym: "L-citrulline N5-carbamoyldihydrolase activity" EXACT [EC:3.5.1.20]
xref: EC:3.5.1.20
xref: MetaCyc:CITRULLINASE-RXN
xref: RHEA:11943
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047782
name: coniferin beta-glucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + coniferin = D-glucose + coniferol." [EC:3.2.1.126, MetaCyc:CONIFERIN-BETA-GLUCOSIDASE-RXN]
synonym: "coniferin b-glucosidase activity" EXACT []
synonym: "coniferin beta-D-glucosidase activity" EXACT [EC:3.2.1.126]
synonym: "coniferin-hydrolyzing beta-glucosidase activity" EXACT [EC:3.2.1.126]
xref: EC:3.2.1.126
xref: MetaCyc:CONIFERIN-BETA-GLUCOSIDASE-RXN
xref: RHEA:12255
is_a: GO:0008422 ! beta-glucosidase activity

[Term]
id: GO:0047783
name: corticosterone 18-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: corticosterone + reduced adrenal ferredoxin + O2 = 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O." [EC:1.14.15.5, MetaCyc:CORTICOSTERONE-18-MONOOXYGENASE-RXN]
synonym: "corticosterone 18-hydroxylase activity" EXACT []
synonym: "corticosterone methyl oxidase activity" RELATED [EC:1.14.15.5]
synonym: "corticosterone,reduced-adrenal-ferredoxin:oxygen oxidoreductase (18-hydroxylating)" EXACT [EC:1.14.15.5]
xref: EC:1.14.15.5
xref: MetaCyc:CORTICOSTERONE-18-MONOOXYGENASE-RXN
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047784
name: cortisol O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + cortisol = CoA + cortisol 21-acetate." [EC:2.3.1.27, RHEA:17076]
synonym: "acetyl-CoA:cortisol O-acetyltransferase activity" EXACT [EC:2.3.1.27]
synonym: "corticosteroid acetyltransferase activity" EXACT [EC:2.3.1.27]
synonym: "corticosteroid-21-O-acetyltransferase activity" EXACT [EC:2.3.1.27]
synonym: "cortisol acetyltransferase activity" EXACT [EC:2.3.1.27]
xref: EC:2.3.1.27
xref: KEGG:R02837
xref: MetaCyc:CORTISOL-O-ACETYLTRANSFERASE-RXN
xref: RHEA:17076
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0047785
name: cortisol sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + cortisol = adenosine 3',5'-diphosphate + cortisol 21-sulfate + H(+)." [EC:2.8.2.18, RHEA:11887]
synonym: "3'-phosphoadenylyl-sulfate:cortisol 21-sulfotransferase activity" EXACT [EC:2.8.2.18]
synonym: "cortisol sulphotransferase activity" EXACT []
synonym: "glucocorticoid sulfotransferase activity" EXACT [EC:2.8.2.18]
synonym: "glucocorticosteroid sulfotransferase activity" BROAD [EC:2.8.2.18]
xref: EC:2.8.2.18
xref: KEGG:R02839
xref: MetaCyc:CORTISOL-SULFOTRANSFERASE-RXN
xref: RHEA:11887
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0047786
name: cortisone alpha-reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4,5alpha-dihydrocortisone + NADP(+) = cortisone + H(+) + NADPH." [EC:1.3.1.4, RHEA:17984]
synonym: "4,5alpha-dihydrocortisone:NADP+ delta4-oxidoreductase activity" EXACT [EC:1.3.1.4]
synonym: "cortisone a-reductase activity" EXACT []
synonym: "cortisone delta4-5alpha-reductase activity" EXACT [EC:1.3.1.4]
synonym: "delta4-3-ketosteroid reductase (5alpha)" EXACT [EC:1.3.1.4]
synonym: "delta4-3-oxosteroid-5alpha-reductase" BROAD [EC:1.3.1.4]
synonym: "delta4-5alpha-reductase activity" EXACT [EC:1.3.1.4]
synonym: "microsomal steroid reductase (5alpha)" EXACT [EC:1.3.1.4]
synonym: "NADPH:Delta4-3-oxosteroid-5alpha-oxidoreductase activity" EXACT [EC:1.3.1.4]
xref: EC:1.3.1.4
xref: KEGG:R02892
xref: MetaCyc:CORTISONE-ALPHA-REDUCTASE-RXN
xref: RHEA:17984
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047787
name: delta4-3-oxosteroid 5beta-reductase activity
namespace: molecular_function
alt_id: GO:0047752
def: "Catalysis of the reactions: (1) 5beta-cholestan-3-one + NADP+ = cholest-4-en-3-one + NADPH + H+ and (2) 17,21-dihydroxy-5beta-pregnane-3,11,20-trione + NADP+ = cortisone + NADPH + H+." [EC:1.3.1.3, MetaCyc:CORTISONE-BETA-REDUCTASE-RXN]
synonym: "3-oxo-5beta-steroid:NADP+ delta4-oxidoreductase activity" EXACT [EC:1.3.1.23]
synonym: "3-oxo-Delta(4)-steroid 5-beta-reductase activity" EXACT [EC:1.3.1.23]
synonym: "3-oxo-delta4-steroid 5beta-reductase activity" EXACT [EC:1.3.1.23]
synonym: "4,5beta-dihydrocortisone:NADP+ delta4-oxidoreductase activity" EXACT [EC:1.3.1.23]
synonym: "5-beta-reductase activity" BROAD [EC:1.3.1.23]
synonym: "5beta-cholestan-3-one:NADP+ 4,5-oxidoreductase activity" EXACT [EC:1.3.1.23]
synonym: "5beta-reductase activity" EXACT [EC:1.3.1.23]
synonym: "androstenedione 5-beta-reductase activity" EXACT [EC:1.3.1.23]
synonym: "androstenedione 5beta-reductase activity" EXACT [EC:1.3.1.23]
synonym: "cholestenone 5-beta-reductase activity" EXACT []
synonym: "cholestenone 5b-reductase activity" EXACT []
synonym: "cholestenone 5beta-reductase activity" EXACT [EC:1.3.1.23]
synonym: "cortisone 5-beta-reductase activity" EXACT [EC:1.3.1.23]
synonym: "cortisone 5beta-reductase activity" EXACT [EC:1.3.1.23]
synonym: "cortisone b-reductase activity" EXACT []
synonym: "cortisone beta-reductase activity" EXACT []
synonym: "cortisone delta(4)-5-beta-reductase activity" EXACT [EC:1.3.1.23]
synonym: "cortisone delta4-5beta-reductase activity" EXACT [EC:1.3.1.23]
synonym: "delta(4)-3-ketosteroid 5-beta-reductase activity" EXACT [EC:1.3.1.23]
synonym: "delta(4)-5-beta-reductase activity" EXACT [EC:1.3.1.23]
synonym: "delta(4)-hydrogenase activity" EXACT [EC:1.3.1.23]
synonym: "delta4-3-ketosteroid 5beta-reductase activity" EXACT [EC:1.3.1.23]
synonym: "delta4-3-oxosteroid 5-beta-reductase activity" EXACT []
synonym: "delta4-5beta-reductase activity" EXACT [EC:1.3.1.23]
synonym: "delta4-hydrogenase activity" EXACT [EC:1.3.1.23]
synonym: "steroid 5-beta-reductase activity" EXACT [EC:1.3.1.23]
synonym: "steroid 5beta-reductase activity" EXACT [EC:1.3.1.23]
synonym: "testosterone 5-beta-reductase activity" EXACT [EC:1.3.1.23]
synonym: "testosterone 5beta-reductase activity" EXACT [EC:1.3.1.23]
xref: EC:1.3.1.3
xref: MetaCyc:CHOLESTENONE-5-BETA-REDUCTASE-RXN
xref: MetaCyc:CORTISONE-BETA-REDUCTASE-RXN
is_a: GO:0035671 ! enone reductase activity

[Term]
id: GO:0047788
name: 2-coumarate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-(2-hydroxyphenyl)propanoate + NAD(+) = trans-2-coumarate + H(+) + NADH." [EC:1.3.1.11, RHEA:21447]
synonym: "3-(2-hydroxyphenyl)propanoate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.11]
synonym: "coumarate reductase activity" EXACT []
synonym: "melilotate dehydrogenase activity" EXACT [EC:1.3.1.11]
xref: EC:1.3.1.11
xref: KEGG:R03709
xref: MetaCyc:COUMARATE-REDUCTASE-RXN
xref: RHEA:21447
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047789
name: creatininase activity
namespace: molecular_function
def: "Catalysis of the reaction: creatinine + H(2)O = creatine." [EC:3.5.2.10, RHEA:14536]
subset: gosubset_prok
synonym: "creatinine amidohydrolase activity" EXACT [EC:3.5.2.10]
synonym: "creatinine hydrolase" BROAD [EC:3.5.2.10]
xref: EC:3.5.2.10
xref: KEGG:R01884
xref: MetaCyc:CREATININASE-RXN
xref: RHEA:14536
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0047790
name: creatinine deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: creatinine + H2O = N-methylhydantoin + NH3." [EC:3.5.4.21, MetaCyc:CREATININE-DEAMINASE-RXN]
subset: gosubset_prok
synonym: "creatinine desiminase activity" EXACT [EC:3.5.4.21]
synonym: "creatinine hydrolase" BROAD [EC:3.5.4.21]
synonym: "creatinine iminohydrolase activity" EXACT [EC:3.5.4.21]
xref: EC:3.5.4.21
xref: MetaCyc:CREATININE-DEAMINASE-RXN
xref: RHEA:12684
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0047791
name: cucurbitacin delta23-reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 23,24-dihydrocucurbitacin + NAD(P)+ = cucurbitacin + NAD(P)H + H+." [EC:1.3.1.5, MetaCyc:CUCURBITACIN-DELTA-23-REDUCTASE-RXN]
synonym: "23,24-dihydrocucurbitacin:NAD(P)+ delta23-oxidoreductase activity" EXACT [EC:1.3.1.5]
synonym: "cucurbitacin D23-reductase activity" EXACT []
synonym: "cucurbitacin delta(23) reductase activity" EXACT []
synonym: "NAD(P)H: cucurbitacin B delta23-oxidoreductase activity" EXACT [EC:1.3.1.5]
xref: EC:1.3.1.5
xref: MetaCyc:CUCURBITACIN-DELTA-23-REDUCTASE-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047792
name: cyanohydrin beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + (S)-4-hydroxymandelonitrile = UDP + (S)-4-hydroxy-mandelonitrile beta-D-glucoside." [EC:2.4.1.85, MetaCyc:CYANOHYDRIN-BETA-GLUCOSYLTRANSFERASE-RXN]
synonym: "cyanohydrin b-glucosyltransferase activity" EXACT []
synonym: "UDP-D-glucose:(S)-4-hydroxymandelonitrile beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.85]
synonym: "UDP-glucose-p-hydroxymandelonitrile glucosyltransferase activity" EXACT [EC:2.4.1.85]
synonym: "UDP-glucose:(S)-4-hydroxymandelonitrile beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.85]
synonym: "UDP-glucose:p-hydroxymandelonitrile-O-glucosyltransferase activity" EXACT [EC:2.4.1.85]
synonym: "UGT85B1 activity" NARROW [EC:2.4.1.85]
synonym: "uridine diphosphoglucose-cyanohydrin glucosyltransferase activity" EXACT [EC:2.4.1.85]
synonym: "uridine diphosphoglucose-p-hydroxymandelonitrile glucosyltransferase activity" EXACT [EC:2.4.1.85]
synonym: "uridine diphosphoglucose:aldehyde cyanohydrin beta-glucosyltransferase activity" EXACT [EC:2.4.1.85]
xref: EC:2.4.1.85
xref: RHEA:12856
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047793
name: cycloeucalenol cycloisomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: cycloeucalenol = obtusifoliol." [EC:5.5.1.9, RHEA:22803]
synonym: "cycloeucalenol lyase (cyclopropane-decyclizing)" EXACT [EC:5.5.1.9]
synonym: "cycloeucalenol--obtusifoliol isomerase activity" EXACT [EC:5.5.1.9]
synonym: "cycloeucalenol-obtusifoliol isomerase activity" EXACT []
xref: EC:5.5.1.9
xref: KEGG:R03775
xref: MetaCyc:CYCLOEUCALENOL-CYCLOISOMERASE-RXN
xref: RHEA:22803
is_a: GO:0016872 ! intramolecular lyase activity

[Term]
id: GO:0047794
name: cyclohexadienyl dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arogenate + NAD+ = L-tyrosine + NADH + CO2." [EC:1.3.1.43, MetaCyc:CYCLOHEXADIENYL-DEHYDROGENASE-RXN]
subset: gosubset_prok
synonym: "arogenate dehydrogenase activity" EXACT [EC:1.3.1.43]
synonym: "arogenic dehydrogenase activity" EXACT [EC:1.3.1.43]
synonym: "L-arogenate:NAD(+) oxidoreductase activity" EXACT [EC:1.3.1.43]
synonym: "L-arogenate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.3.1.43]
synonym: "L-arogenate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.43]
synonym: "pretyrosine dehydrogenase activity" EXACT [EC:1.3.1.43]
xref: EC:1.3.1.43
xref: MetaCyc:CYCLOHEXADIENYL-DEHYDROGENASE-RXN
xref: RHEA:12259
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047795
name: cyclohexane-1,2-diol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-cyclohexane-1,2-diol + NAD+ = 2-hydroxycyclohexan-1-one + NADH." [EC:1.1.1.174, MetaCyc:CYCLOHEXANE-12-DIOL-DEHYDROGENASE-RXN]
synonym: "trans-cyclohexane-1,2-diol:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.174]
xref: EC:1.1.1.174
xref: MetaCyc:CYCLOHEXANE-12-DIOL-DEHYDROGENASE-RXN
xref: RHEA:18144
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047796
name: cyclohexane-1,3-dione hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyclohexane-1,3-dione + H(2)O = 5-oxohexanoate + H(+)." [EC:3.7.1.10, RHEA:16476]
synonym: "1,3-cyclohexanedione hydrolase activity" EXACT [EC:3.7.1.10]
synonym: "cyclohexane-1,3-dione acylhydrolase (decyclizing)" EXACT [EC:3.7.1.10]
xref: EC:3.7.1.10
xref: KEGG:R03211
xref: MetaCyc:CYCLOHEXANE-13-DIONE-HYDROLASE-RXN
xref: RHEA:16476
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0047797
name: cyclohexanone dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: A + cyclohexanone = AH(2) + cyclohex-2-enone." [EC:1.3.99.14, RHEA:21783]
synonym: "cyclohexanone:(acceptor) 2-oxidoreductase activity" EXACT [EC:1.3.99.14]
synonym: "cyclohexanone:acceptor 2-oxidoreductase activity" EXACT [EC:1.3.99.14]
xref: EC:1.3.99.14
xref: KEGG:R02234
xref: MetaCyc:CYCLOHEXANONE-DEHYDROGENASE-RXN
xref: RHEA:21783
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0047798
name: cyclomaltodextrinase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + cyclomaltodextrin = linear maltodextrin." [EC:3.2.1.54, MetaCyc:CYCLOMALTODEXTRINASE-RXN]
subset: gosubset_prok
synonym: "cyclodextrinase activity" EXACT [EC:3.2.1.54]
synonym: "cycloheptaglucanase activity" EXACT [EC:3.2.1.54]
synonym: "cyclohexaglucanase activity" EXACT [EC:3.2.1.54]
synonym: "cyclomaltodextrin dextrin-hydrolase (decyclizing)" EXACT [EC:3.2.1.54]
xref: EC:3.2.1.54
xref: MetaCyc:CYCLOMALTODEXTRINASE-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0047799
name: cyclopentanone monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyclopentanone + H(+) + NADPH + O(2) = 5-valerolactone + H(2)O + NADP(+)." [EC:1.14.13.16, RHEA:15740]
synonym: "cyclopentanone 1,2-monooxygenase activity" EXACT [EC:1.14.13.16]
synonym: "cyclopentanone oxygenase activity" EXACT [EC:1.14.13.16]
synonym: "cyclopentanone,NADPH:oxygen oxidoreductase (5-hydroxylating, lactonizing)" EXACT [EC:1.14.13.16]
xref: EC:1.14.13.16
xref: KEGG:R02554
xref: MetaCyc:CYCLOPENTANONE-MONOOXYGENASE-RXN
xref: RHEA:15740
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047800
name: cysteamine dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cysteamine + O(2) = H(+) + hypotaurine." [EC:1.13.11.19, RHEA:14412]
synonym: "2-aminoethanethiol:oxygen oxidoreductase activity" EXACT [EC:1.13.11.19]
synonym: "cysteamine oxygenase activity" EXACT [EC:1.13.11.19]
synonym: "cysteamine:oxygen oxidoreductase activity" EXACT [EC:1.13.11.19]
synonym: "persulfurase activity" RELATED [EC:1.13.11.19]
xref: EC:1.13.11.19
xref: KEGG:R02467
xref: MetaCyc:CYSTEAMINE-DIOXYGENASE-RXN
xref: RHEA:14412
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0047801
name: L-cysteine:2-oxoglutarate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-cysteine + 2-oxoglutarate = mercaptopyruvate + L-glutamate." [EC:2.6.1.3, MetaCyc:CYSTEINE-AMINOTRANSFERASE-RXN]
synonym: "CGT" RELATED [EC:2.6.1.3]
synonym: "cysteine aminotransferase activity" BROAD []
synonym: "cysteine transaminase activity" BROAD [EC:2.6.1.3]
synonym: "L-cysteine aminotransferase activity" BROAD [EC:2.6.1.3]
xref: EC:2.6.1.3
xref: MetaCyc:CYSTEINE-AMINOTRANSFERASE-RXN
xref: RHEA:17444
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047802
name: cysteine-conjugate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + S-(4-bromophenyl)-L-cysteine = (4-bromophenylsulfanyl)pyruvate + L-glutamate." [EC:2.6.1.75, RHEA:13488]
synonym: "cysteine conjugate aminotransferase activity" EXACT [EC:2.6.1.75]
synonym: "cysteine-conjugate alpha-ketoglutarate transaminase (CAT-1)" EXACT [EC:2.6.1.75]
synonym: "S-(4-bromophenyl)-L-cysteine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.75]
xref: EC:2.6.1.75
xref: KEGG:R04338
xref: MetaCyc:CYSTEINE-CONJUGATE-TRANSAMINASE-RXN
xref: RHEA:13488
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047803
name: cysteine lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-cysteine + sulfite = L-cysteate + sulfide." [EC:4.4.1.10, MetaCyc:CYSTEINE-LYASE-RXN]
synonym: "cysteine (sulfite) lyase activity" EXACT [EC:4.4.1.10]
synonym: "L-cysteine hydrogen-sulfide-lyase (adding sulfite)" EXACT [EC:4.4.1.10]
synonym: "L-cysteine hydrogen-sulfide-lyase (adding sulfite; L-cysteate-forming)" EXACT [EC:4.4.1.10]
xref: EC:4.4.1.10
xref: MetaCyc:CYSTEINE-LYASE-RXN
xref: RHEA:20919
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0047804
name: cysteine-S-conjugate beta-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: RS-CH2-CH(NH3+)COO- = RSH + NH3 + pyruvate." [EC:4.4.1.13, MetaCyc:CYSTEINE-S-CONJUGATE-BETA-LYASE-RXN]
subset: gosubset_prok
synonym: "cysteine conjugate beta-lyase activity" EXACT [EC:4.4.1.13]
synonym: "cysteine-S-conjugate b-lyase activity" EXACT []
synonym: "glutamine transaminase K/cysteine conjugate beta-lyase activity" EXACT [EC:4.4.1.13]
synonym: "L-cysteine-S-conjugate thiol-lyase (deaminating) activity" EXACT [EC:4.4.1.13]
synonym: "L-cysteine-S-conjugate thiol-lyase (deaminating; pyruvate-forming)" EXACT [EC:4.4.1.13]
xref: EC:4.4.1.13
xref: MetaCyc:CYSTEINE-S-CONJUGATE-BETA-LYASE-RXN
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0047805
name: cytidylate cyclase activity
namespace: molecular_function
def: "Catalysis of the reaction: CTP = 3',5'-cyclic CMP + diphosphate + H(+)." [EC:4.6.1.6, RHEA:14740]
synonym: "3',5'-cyclic-CMP synthase activity" EXACT [EC:4.6.1.6]
synonym: "3'5'-cyclic-CMP synthase activity" EXACT [EC:4.6.1.6]
synonym: "CTP diphosphate-lyase (cyclizing)" EXACT [EC:4.6.1.6]
synonym: "CTP diphosphate-lyase (cyclizing; 3',5'-cyclic-CMP-forming)" EXACT [EC:4.6.1.6]
synonym: "cytidyl cyclase activity" EXACT [EC:4.6.1.6]
synonym: "cytidylyl cyclase activity" EXACT [EC:4.6.1.6]
xref: EC:4.6.1.6
xref: KEGG:R00574
xref: MetaCyc:CYTIDYLATE-CYCLASE-RXN
xref: RHEA:14740
is_a: GO:0009975 ! cyclase activity
is_a: GO:0016849 ! phosphorus-oxygen lyase activity
relationship: part_of GO:0009190 ! cyclic nucleotide biosynthetic process

[Term]
id: GO:0047806
name: cytochrome-c3 hydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 H2 + ferricytochrome c3 = 4 H+ + ferrocytochrome c3." [EC:1.12.2.1, MetaCyc:CYTOCHROME-C3-HYDROGENASE-RXN]
subset: gosubset_prok
synonym: "cytochrome c3 reductase activity" EXACT [EC:1.12.2.1]
synonym: "cytochrome hydrogenase activity" BROAD [EC:1.12.2.1]
synonym: "H(2):ferricytochrome c3 oxidoreductase activity" EXACT [EC:1.12.2.1]
synonym: "H2:ferricytochrome c3 oxidoreductase activity" EXACT [EC:1.12.2.1]
synonym: "hydrogen:ferricytochrome-c3 oxidoreductase activity" EXACT [EC:1.12.2.1]
xref: EC:1.12.2.1
xref: MetaCyc:CYTOCHROME-C3-HYDROGENASE-RXN
xref: UM-BBD_enzymeID:e0481
is_a: GO:0016697 ! oxidoreductase activity, acting on hydrogen as donor, cytochrome as acceptor

[Term]
id: GO:0047807
name: cytokinin 7-beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-alkylaminopurine + UDP-D-glucose = 6-alkylamino-7-beta-D-glucosylpurine + H+ + UDP. This reaction is an N-glucosylation event." [EC:2.4.1.118, MetaCyc:CYTOKININ-7-BETA-GLUCOSYLTRANSFERASE-RXN]
synonym: "cytokinin 7-b-glucosyltransferase activity" EXACT []
synonym: "cytokinin 7-glucosyltransferase activity" EXACT [EC:2.4.1.118]
synonym: "UDP-glucose-zeatin 7-glucosyltransferase activity" EXACT [EC:2.4.1.118]
synonym: "UDP-glucose:zeatin 7-glucosyltransferase activity" EXACT [EC:2.4.1.118]
synonym: "UDPglucose:zeatin 7-glucosyltransferase activity" EXACT [EC:2.4.1.118]
synonym: "uridine diphosphoglucose-zeatin 7-glucosyltransferase activity" EXACT [EC:2.4.1.118]
xref: EC:2.4.1.118
xref: KEGG:R04071
xref: MetaCyc:CYTOKININ-7-BETA-GLUCOSYLTRANSFERASE-RXN
xref: RHEA:23275
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047808
name: D(-)-tartrate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-tartrate = H(2)O + oxaloacetate." [EC:4.2.1.81, RHEA:18292]
synonym: "(S,S)-tartrate hydro-lyase (oxaloacetate-forming)" EXACT [EC:4.2.1.81]
synonym: "(S,S)-tartrate hydro-lyase activity" EXACT [EC:4.2.1.81]
synonym: "D-tartrate dehydratase activity" EXACT [EC:4.2.1.81]
xref: EC:4.2.1.81
xref: KEGG:R00340
xref: MetaCyc:D--TARTRATE-DEHYDRATASE-RXN
xref: RHEA:18292
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047809
name: D-2-hydroxy-acid dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-lactate + A = AH(2) + pyruvate." [EC:1.1.99.6, RHEA:15092]
synonym: "(R)-2-hydroxy-acid:(acceptor) 2-oxidoreductase activity" EXACT [EC:1.1.99.6]
synonym: "2-hydroxy acid dehydrogenase activity" EXACT [EC:1.1.99.6]
xref: EC:1.1.99.6
xref: KEGG:R00297
xref: MetaCyc:D-2-HYDROXY-ACID-DEHYDROGENASE-RXN
xref: RHEA:15092
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0047810
name: D-alanine:2-oxoglutarate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-alanine + 2-oxoglutarate = pyruvate + D-glutamate." [EC:2.6.1.21, MetaCyc:D-ALANINE-AMINOTRANSFERASE-RXN]
subset: gosubset_prok
synonym: "D-alanine aminotransferase activity" EXACT []
synonym: "D-alanine transaminase activity" BROAD [EC:2.6.1.21]
synonym: "D-alanine-D-glutamate transaminase activity" EXACT [EC:2.6.1.21]
synonym: "D-amino acid aminotransferase activity" BROAD [EC:2.6.1.21]
synonym: "D-amino acid transaminase activity" BROAD [EC:2.6.1.21]
synonym: "D-amino-acid transaminase activity" BROAD [EC:2.6.1.21]
synonym: "D-aspartate aminotransferase activity" RELATED [EC:2.6.1.21]
synonym: "D-aspartate transaminase activity" RELATED [EC:2.6.1.21]
synonym: "D-aspartic aminotransferase activity" RELATED [EC:2.6.1.21]
xref: EC:2.6.1.21
xref: MetaCyc:D-ALANINE-AMINOTRANSFERASE-RXN
xref: RHEA:15872
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047811
name: D-alanine gamma-glutamyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-alanine + L-glutamine = gamma-L-glutamyl-D-alanine + NH(4)(+)." [EC:2.3.2.14, RHEA:23559]
synonym: "D-alanine g-glutamyltransferase activity" EXACT []
synonym: "L-glutamine:D-alanine gamma-glutamyltransferase activity" EXACT [EC:2.3.2.14]
xref: EC:2.3.2.14
xref: KEGG:R01149
xref: MetaCyc:D-ALANINE-GAMMA-GLUTAMYLTRANSFERASE-RXN
xref: RHEA:23559
is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups

[Term]
id: GO:0047812
name: D-amino-acid N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + a D-amino acid = CoA + an N-acetyl-D-amino-acid." [EC:2.3.1.36, MetaCyc:D-AMINO-ACID-N-ACETYLTRANSFERASE-RXN]
synonym: "acetyl-CoA:D-amino-acid N-acetyltransferase activity" EXACT [EC:2.3.1.36]
synonym: "D-amino acid acetyltransferase activity" EXACT [EC:2.3.1.36]
synonym: "D-amino acid-alpha-N-acetyltransferase activity" EXACT [EC:2.3.1.36]
xref: EC:2.3.1.36
xref: MetaCyc:D-AMINO-ACID-N-ACETYLTRANSFERASE-RXN
xref: RHEA:20707
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0047813
name: D-arabinitol 4-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-arabinitol + NAD+ = D-xylulose + NADH." [EC:1.1.1.11, MetaCyc:D-ARABINITOL-4-DEHYDROGENASE-RXN]
subset: gosubset_prok
xref: EC:1.1.1.11
xref: MetaCyc:D-ARABINITOL-4-DEHYDROGENASE-RXN
xref: RHEA:17924
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047814
name: D-arabinokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-arabinose + ATP = D-arabinose 5-phosphate + ADP." [EC:2.7.1.54, RHEA:24591]
synonym: "ATP:D-arabinose 5-phosphotransferase activity" EXACT [EC:2.7.1.54]
synonym: "D-arabinokinase (phosphorylating)" EXACT [EC:2.7.1.54]
xref: EC:2.7.1.54
xref: KEGG:R01573
xref: MetaCyc:D-ARABINOKINASE-RXN
xref: RHEA:24591
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047815
name: D-arabinonolactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-arabinono-1,4-lactone + H(2)O = D-arabinonate + H(+)." [EC:3.1.1.30, RHEA:23111]
synonym: "D-arabinono-1,4-lactone lactonohydrolase activity" EXACT [EC:3.1.1.30]
xref: EC:3.1.1.30
xref: KEGG:R02714
xref: MetaCyc:D-ARABINONOLACTONASE-RXN
xref: RHEA:23111
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0047816
name: D-arabinose 1-dehydrogenase (NAD) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-arabinose + NAD+ = D-arabinono-1,4-lactone + NADH." [EC:1.1.1.116, MetaCyc:D-ARABINOSE-1-DEHYDROGENASE-RXN]
synonym: "arabinose(fucose)dehydrogenase activity" EXACT [EC:1.1.1.116]
synonym: "D-arabinose:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.116]
synonym: "NAD-pentose-dehydrogenase activity" EXACT [EC:1.1.1.116]
xref: EC:1.1.1.116
xref: MetaCyc:D-ARABINOSE-1-DEHYDROGENASE-RXN
xref: RHEA:20460
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047817
name: D-arginase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-arginine + H(2)O = D-ornithine + urea." [EC:3.5.3.10, RHEA:12904]
synonym: "D-arginine amidinohydrolase activity" EXACT [EC:3.5.3.10]
xref: EC:3.5.3.10
xref: KEGG:R02458
xref: MetaCyc:D-ARGINASE-RXN
xref: RHEA:12904
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0047818
name: D-fuconate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-fuconate = 2-dehydro-3-deoxy-D-fuconate + H(2)O." [EC:4.2.1.67, RHEA:12952]
synonym: "D-fuconate hydratase activity" EXACT []
synonym: "D-fuconate hydro-lyase (2-dehydro-3-deoxy-D-fuconate-forming)" EXACT [EC:4.2.1.67]
synonym: "D-fuconate hydro-lyase activity" EXACT [EC:4.2.1.67]
xref: EC:4.2.1.67
xref: KEGG:R03671
xref: MetaCyc:D-FUCONATE-HYDRATASE-RXN
xref: RHEA:12952
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047819
name: D-glutamate(D-aspartate) oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glutamate + H2O + O2 = 2-oxoglutarate + NH3 + H2O2, and D-aspartate + H2O + O2 = oxaloacetate + NH3 + H2O2." [EC:1.4.3.15, MetaCyc:D-GLUTAMATED-ASPARTATE-OXIDASE-RXN]
comment: For the individual reactions, see instead 'D-glutamate oxidase activity ;GO:0047821' and 'D-aspartate oxidase activity ; GO:0008445'.
synonym: "D-glutamate(D-aspartate):oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.15]
synonym: "D-glutamic-aspartic oxidase activity" EXACT [EC:1.4.3.15]
synonym: "D-monoaminodicarboxylic acid oxidase activity" EXACT [EC:1.4.3.15]
xref: EC:1.4.3.15
xref: MetaCyc:D-GLUTAMATED-ASPARTATE-OXIDASE-RXN
is_a: GO:0003884 ! D-amino-acid oxidase activity

[Term]
id: GO:0047820
name: D-glutamate cyclase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glutamate = 5-oxo-D-proline + H(2)O." [EC:4.2.1.48, RHEA:22363]
synonym: "D-glutamate hydro-lyase (cyclizing)" EXACT [EC:4.2.1.48]
synonym: "D-glutamate hydro-lyase (cyclizing; 5-oxo-D-proline-forming)" EXACT [EC:4.2.1.48]
xref: EC:4.2.1.48
xref: KEGG:R01583
xref: MetaCyc:D-GLUTAMATE-CYCLASE-RXN
xref: RHEA:22363
is_a: GO:0009975 ! cyclase activity
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047821
name: D-glutamate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glutamate + H2O + O2 = 2-oxoglutarate + NH3 + H2O2." [EC:1.4.3.7, MetaCyc:D-GLUTAMATE-OXIDASE-RXN]
synonym: "D-glutamate:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.7]
synonym: "D-glutamic acid oxidase activity" EXACT [EC:1.4.3.7]
synonym: "D-glutamic oxidase activity" EXACT [EC:1.4.3.7]
xref: EC:1.4.3.7
xref: KEGG:R00279
xref: MetaCyc:D-GLUTAMATE-OXIDASE-RXN
xref: RHEA:10031
is_a: GO:0003884 ! D-amino-acid oxidase activity

[Term]
id: GO:0047822
name: hypotaurine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + hypotaurine + NAD(+) = H(+) + NADH + taurine." [EC:1.8.1.3, RHEA:17388]
synonym: "hypotaurine:NAD+ oxidoreductase activity" EXACT [EC:1.8.1.3]
xref: EC:1.8.1.3
xref: KEGG:R01681
xref: MetaCyc:HYPOTAURINE-DEHYDROGENASE-RXN
xref: Reactome:REACT_115982 "Oxidation of hypotaurine to taurine, Homo sapiens"
xref: RHEA:17388
is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor

[Term]
id: GO:0047823
name: D-glutamyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L(or D)-glutamine + D-glutamyl-peptide = NH3 + 5-glutamyl-D-glutamyl-peptide." [EC:2.3.2.1, MetaCyc:D-GLUTAMYLTRANSFERASE-RXN]
synonym: "D-gamma-glutamyl transpeptidase activity" EXACT [EC:2.3.2.1]
synonym: "D-glutamyl transpeptidase activity" EXACT [EC:2.3.2.1]
synonym: "glutamine:D-glutamyl-peptide 5-glutamyltransferase activity" EXACT [EC:2.3.2.1]
xref: EC:2.3.2.1
xref: MetaCyc:D-GLUTAMYLTRANSFERASE-RXN
is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups

[Term]
id: GO:0047824
name: D-iditol 2-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-iditol + NAD+ = D-sorbose + NADH." [EC:1.1.1.15, MetaCyc:D-IDITOL-2-DEHYDROGENASE-RXN]
xref: EC:1.1.1.15
xref: MetaCyc:D-IDITOL-2-DEHYDROGENASE-RXN
xref: RHEA:12728
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
is_a: GO:0031320 ! hexitol dehydrogenase activity

[Term]
id: GO:0047825
name: D-lactate-2-sulfatase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-2-O-sulfolactate + H(2)O = (R)-lactate + H(+) + sulfate." [EC:3.1.6.17, RHEA:20340]
synonym: "(S)-2-O-sulfolactate 2-sulfohydrolase activity" EXACT [EC:3.1.6.17]
synonym: "D-lactate-2-sulphatase activity" EXACT []
xref: EC:3.1.6.17
xref: KEGG:R01448
xref: MetaCyc:D-LACTATE-2-SULFATASE-RXN
xref: RHEA:20340
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0047826
name: D-lysine 5,6-aminomutase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-lysine = 2,5-diaminohexanoate." [EC:5.4.3.4, RHEA:18244]
synonym: "adenosylcobalamin-dependent D-lysine 5,6-aminomutase activity" EXACT [EC:5.4.3.4]
synonym: "D-2,6-diaminohexanoate 5,6-aminomutase activity" EXACT [EC:5.4.3.4]
synonym: "D-alpha-lysine mutase activity" EXACT [EC:5.4.3.4]
xref: EC:5.4.3.4
xref: KEGG:R02852
xref: MetaCyc:D-LYSINE-56-AMINOMUTASE-RXN
xref: RHEA:18244
is_a: GO:0016869 ! intramolecular transferase activity, transferring amino groups

[Term]
id: GO:0047827
name: D-lysopine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-lysopine + H(2)O + NADP(+) = L-lysine + H(+) + NADPH + pyruvate." [EC:1.5.1.16, RHEA:17628]
subset: gosubset_prok
synonym: "2-N-(D-1-carboxyethyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)" EXACT [EC:1.5.1.16]
synonym: "D(+)-lysopine dehydrogenase activity" EXACT [EC:1.5.1.16]
synonym: "D-lysopine synthase activity" EXACT [EC:1.5.1.16]
synonym: "lysopine dehydrogenase activity" EXACT [EC:1.5.1.16]
synonym: "N2-(D-1-carboxyethyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)" EXACT [EC:1.5.1.16]
xref: EC:1.5.1.16
xref: KEGG:R00452
xref: MetaCyc:D-LYSOPINE-DEHYDROGENASE-RXN
xref: RHEA:17628
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047828
name: D-lyxose ketol-isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-lyxose = D-xylulose." [EC:5.3.1.15, RHEA:14204]
synonym: "D-lyxose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.15]
synonym: "D-lyxose isomerase activity" EXACT [EC:5.3.1.15]
xref: EC:5.3.1.15
xref: KEGG:R01898
xref: MetaCyc:D-LYXOSE-KETOL-ISOMERASE-RXN
xref: RHEA:14204
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0047829
name: D-nopaline dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: N2-(D-1,3-dicarboxypropyl)-L-arginine + NADP+ + H2O = L-arginine + 2-oxoglutarate + NADPH." [EC:1.5.1.19, MetaCyc:D-NOPALINE-DEHYDROGENASE-RXN]
subset: gosubset_prok
synonym: "2-N-(D-1,3-dicarboxypropyl)-L-arginine:NADP+ oxidoreductase (L-arginine-forming)" EXACT [EC:1.5.1.19]
synonym: "D-nopaline synthase activity" EXACT [EC:1.5.1.19]
synonym: "N2-(D-1,3-dicarboxypropyl)-L-arginine:NADP+ oxidoreductase (L-arginine-forming)" EXACT [EC:1.5.1.19]
synonym: "nopaline dehydrogenase activity" EXACT [EC:1.5.1.19]
synonym: "nopaline synthase activity" EXACT [EC:1.5.1.19]
synonym: "NOS activity" EXACT [EC:1.5.1.19]
xref: EC:1.5.1.19
xref: MetaCyc:D-NOPALINE-DEHYDROGENASE-RXN
xref: RHEA:19640
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047830
name: D-octopine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: N2-(D-1-carboxyethyl)-L-arginine + NAD+ + H2O = L-arginine + pyruvate + NADH." [EC:1.5.1.11, MetaCyc:D-OCTOPINE-DEHYDROGENASE-RXN]
subset: gosubset_prok
synonym: "2-N-(D-1-carboxyethyl)-L-arginine:NAD+ oxidoreductase (L-arginine-forming)" EXACT [EC:1.5.1.11]
synonym: "D-octopine synthase activity" EXACT [EC:1.5.1.11]
synonym: "N2-(D-1-carboxyethyl)-L-arginine:NAD+ oxidoreductase (L-arginine-forming)" EXACT [EC:1.5.1.11]
synonym: "octopine dehydrogenase activity" EXACT [EC:1.5.1.11]
synonym: "octopine:NAD oxidoreductase activity" EXACT [EC:1.5.1.11]
synonym: "ODH activity" EXACT [EC:1.5.1.11]
xref: EC:1.5.1.11
xref: MetaCyc:D-OCTOPINE-DEHYDROGENASE-RXN
xref: RHEA:16288
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047831
name: D-ornithine 4,5-aminomutase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-ornithine = (2R,4S)-2,4-diaminopentanoate." [EC:5.4.3.5, RHEA:14896]
synonym: "D-alpha-ornithine 5,4-aminomutase activity" EXACT [EC:5.4.3.5]
synonym: "D-ornithine aminomutase activity" EXACT [EC:5.4.3.5]
xref: EC:5.4.3.5
xref: KEGG:R02461
xref: MetaCyc:ORNMUTST-RXN
xref: RHEA:14896
is_a: GO:0016869 ! intramolecular transferase activity, transferring amino groups

[Term]
id: GO:0047832
name: D-pinitol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5D-5-O-methyl-chiro-inositol + NADP(+) = 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADPH." [EC:1.1.1.142, RHEA:20440]
subset: gosubset_prok
synonym: "1D-3-O-methyl-chiro-inositol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.142]
synonym: "5D-5-O-methyl-chiro-inositol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.142]
xref: EC:1.1.1.142
xref: KEGG:R03498
xref: MetaCyc:D-PINITOL-DEHYDROGENASE-RXN
xref: RHEA:20440
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047833
name: D-sorbitol dehydrogenase (acceptor) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-sorbitol + acceptor = L-sorbose + reduced acceptor." [EC:1.1.99.21, MetaCyc:D-SORBITOL-DEHYDROGENASE-RXN]
synonym: "D-sorbitol dehydrogenase activity" EXACT []
synonym: "D-sorbitol:(acceptor) 1-oxidoreductase activity" EXACT [EC:1.1.99.21]
synonym: "D-sorbitol:acceptor 1-oxidoreductase activity" EXACT [EC:1.1.99.21]
xref: EC:1.1.99.21
xref: MetaCyc:D-SORBITOL-DEHYDROGENASE-RXN
xref: RHEA:21323
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0047834
name: D-threo-aldose 1-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a D-threo-aldose + NAD+ = a D-threo-aldono-1,5-lactone + NADH." [EC:1.1.1.122, MetaCyc:D-THREO-ALDOSE-1-DEHYDROGENASE-RXN]
subset: gosubset_prok
synonym: "(2S,3R)-aldose dehydrogenase activity" EXACT [EC:1.1.1.122]
synonym: "D-threo-aldose:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.122]
synonym: "dehydrogenase, L-fucose" EXACT [EC:1.1.1.122]
synonym: "L-fucose (D-arabinose) dehydrogenase activity" EXACT [EC:1.1.1.122]
synonym: "L-fucose dehydrogenase activity" EXACT [EC:1.1.1.122]
xref: EC:1.1.1.122
xref: MetaCyc:D-THREO-ALDOSE-1-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047835
name: D-tryptophan N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-tryptophan + acetyl-CoA = N-acetyl-D-tryptophan + CoA + H(+)." [EC:2.3.1.34, RHEA:10063]
synonym: "acetyl-CoA-D-tryptophan-alpha-N-acetyltransferase activity" EXACT [EC:2.3.1.34]
synonym: "acetyl-CoA:D-tryptophan N-acetyltransferase activity" EXACT [EC:2.3.1.34]
synonym: "D-tryptophan acetyltransferase activity" EXACT [EC:2.3.1.34]
xref: EC:2.3.1.34
xref: KEGG:R02481
xref: MetaCyc:D-TRYPTOPHAN-N-ACETYLTRANSFERASE-RXN
xref: RHEA:10063
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0047836
name: D-tryptophan N-malonyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-tryptophan + malonyl-CoA = N(2)-malonyl-D-tryptophan + CoA + H(+)." [EC:2.3.1.112, RHEA:23323]
synonym: "malonyl-CoA:D-tryptophan N-malonyltransferase activity" EXACT [EC:2.3.1.112]
xref: EC:2.3.1.112
xref: KEGG:R02482
xref: MetaCyc:D-TRYPTOPHAN-N-MALONYLTRANSFERASE-RXN
xref: RHEA:23323
is_a: GO:0050735 ! N-malonyltransferase activity

[Term]
id: GO:0047837
name: D-xylose 1-dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-xylose + NADP(+) = D-xylono-1,5-lactone + H(+) + NADPH." [EC:1.1.1.179, RHEA:22003]
subset: gosubset_prok
synonym: "D-xylose (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT [EC:1.1.1.179]
synonym: "D-xylose-NADP dehydrogenase activity" EXACT [EC:1.1.1.179]
synonym: "D-xylose:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.179]
synonym: "D-xylose:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.179]
xref: EC:1.1.1.179
xref: KEGG:R01430
xref: MetaCyc:D-XYLOSE-1-DEHYDROGENASE-NADP+-RXN
xref: RHEA:22003
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047838
name: D-xylose 1-dehydrogenase (NAD) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-xylose + NAD+ = D-xylonolactone + NADH." [EC:1.1.1.175, MetaCyc:D-XYLOSE-1-DEHYDROGENASE-RXN]
synonym: "(NAD)-linked D-xylose dehydrogenase activity" EXACT [EC:1.1.1.175]
synonym: "D-xylose dehydrogenase activity" EXACT [EC:1.1.1.175]
synonym: "D-xylose:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.175]
synonym: "NAD-D-xylose" RELATED [EC:1.1.1.175]
synonym: "NAD-D-xylose dehydrogenase activity" EXACT [EC:1.1.1.175]
synonym: "NAD-linked D-xylose dehydrogenase activity" EXACT [EC:1.1.1.175]
xref: EC:1.1.1.175
xref: MetaCyc:D-XYLOSE-1-DEHYDROGENASE-RXN
xref: RHEA:13864
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047839
name: dATP(dGTP)-DNA purinetransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: dATP + depurinated DNA = ribose triphosphate + DNA." [EC:2.6.99.1, MetaCyc:DATPDGTP--DNA-PURINE-TRANSFERASE-RXN]
synonym: "dATP(dGTP)--DNA purine transferase activity" EXACT []
synonym: "dATP(dGTP):depurinated-DNA purine transferase activity" EXACT [EC:2.6.99.1]
xref: EC:2.6.99.1
xref: MetaCyc:DATPDGTP--DNA-PURINE-TRANSFERASE-RXN
is_a: GO:0016769 ! transferase activity, transferring nitrogenous groups

[Term]
id: GO:0047840
name: dCTP diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: dCTP + H2O = dCMP + diphosphate." [EC:3.6.1.12, MetaCyc:DCTP-PYROPHOSPHATASE-RXN]
synonym: "dCTP nucleotidohydrolase activity" EXACT [EC:3.6.1.12]
synonym: "dCTP pyrophosphatase activity" EXACT []
synonym: "dCTPase activity" EXACT [EC:3.6.1.12]
synonym: "deoxy-CTPase activity" EXACT [EC:3.6.1.12]
synonym: "deoxycytidine triphosphatase activity" EXACT [EC:3.6.1.12]
synonym: "deoxycytidine-triphosphatase activity" EXACT [EC:3.6.1.12]
xref: EC:3.6.1.12
xref: MetaCyc:DCTP-PYROPHOSPHATASE-RXN
xref: RHEA:22639
is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity

[Term]
id: GO:0047841
name: dehydrogluconokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-dehydro-D-gluconate + ATP = 6-phospho-2-dehydro-D-gluconate + ADP + 2 H(+)." [EC:2.7.1.13, RHEA:10791]
synonym: "2-ketogluconate kinase activity" EXACT [EC:2.7.1.13]
synonym: "2-ketogluconokinase activity" EXACT [EC:2.7.1.13]
synonym: "ATP:2-dehydro-D-gluconate 6-phosphotransferase activity" EXACT [EC:2.7.1.13]
synonym: "dehydogluconokinase activity" EXACT []
synonym: "ketogluconokinase (phosphorylating)" EXACT [EC:2.7.1.13]
synonym: "ketogluconokinase activity" EXACT [EC:2.7.1.13]
xref: EC:2.7.1.13
xref: KEGG:R02658
xref: MetaCyc:DEHYDOGLUCONOKINASE-RXN
xref: RHEA:10791
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047842
name: dehydro-L-gulonate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-dehydro-L-gulonate + H(+) = L-xylulose + CO(2)." [EC:4.1.1.34, RHEA:11087]
synonym: "3-dehydro-L-gulonate carboxy-lyase (L-xylulose-forming)" EXACT [EC:4.1.1.34]
synonym: "3-dehydro-L-gulonate carboxy-lyase activity" EXACT [EC:4.1.1.34]
synonym: "3-keto-L-gulonate decarboxylase activity" EXACT [EC:4.1.1.34]
synonym: "keto-L-gulonate decarboxylase activity" EXACT [EC:4.1.1.34]
xref: EC:4.1.1.34
xref: KEGG:R01905
xref: MetaCyc:DEHYDRO-L-GULONATE-DECARBOXYLASE-RXN
xref: RHEA:11087
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047843
name: dehydrogluconate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-dehydro-D-gluconate + A = 2,5-didehydro-D-gluconate + AH(2)." [EC:1.1.99.4, RHEA:12371]
synonym: "2-dehydro-D-gluconate:acceptor 2-oxidoreductase activity" EXACT [EC:1.1.99.4]
synonym: "2-keto-D-gluconate dehydrogenase activity" EXACT [EC:1.1.99.4]
synonym: "2-oxogluconate dehydrogenase activity" EXACT [EC:1.1.99.4]
synonym: "alpha-ketogluconate dehydrogenase activity" EXACT [EC:1.1.99.4]
synonym: "ketogluconate dehydrogenase activity" EXACT [EC:1.1.99.4]
xref: EC:1.1.99.4
xref: KEGG:R07153
xref: MetaCyc:DEHYDROGLUCONATE-DEHYDROGENASE-RXN
xref: RHEA:12371
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0047844
name: deoxycytidine deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: deoxycytidine + H2O = deoxyuridine + NH3." [EC:3.5.4.14, MetaCyc:DEOXYCYTIDINE-DEAMINASE-RXN]
subset: gosubset_prok
synonym: "deoxycytidine aminohydrolase activity" EXACT [EC:3.5.4.14]
xref: EC:3.5.4.14
xref: MetaCyc:CYTIDEAM-RXN
xref: RHEA:13436
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0047845
name: deoxylimonate A-ring-lactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: deoxylimonoate + H(2)O = deoxylimononate D-ring-lactone + H(+)." [EC:3.1.1.46, RHEA:15000]
synonym: "deoxylimonate A-ring-lactonohydrolase activity" EXACT [EC:3.1.1.46]
xref: EC:3.1.1.46
xref: KEGG:R03803
xref: MetaCyc:DEOXYLIMONATE-A-RING-LACTONASE-RXN
xref: RHEA:15000
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0047846
name: deoxynucleotide 3'-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: a deoxynucleoside 3'-phosphate + H2O = a deoxynucleoside + phosphate." [EC:3.1.3.34, MetaCyc:DEOXYNUCLEOTIDE-3-PHOSPHATASE-RXN]
synonym: "3'-deoxynucleotidase activity" EXACT [EC:3.1.3.34]
synonym: "3'-deoxyribonucleotidase activity" EXACT [EC:3.1.3.34]
synonym: "deoxyribonucleotide 3'-phosphohydrolase activity" EXACT [EC:3.1.3.34]
xref: EC:3.1.3.34
xref: MetaCyc:DEOXYNUCLEOTIDE-3-PHOSPHATASE-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0047847
name: deoxyuridine phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: deoxyuridine + phosphate = uracil + deoxy-D-ribose 1-phosphate." [EC:2.4.2.23, MetaCyc:DEOXYURIDINE-PHOSPHORYLASE-RXN]
synonym: "2'-deoxyuridine:phosphate 2-deoxy-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.23]
synonym: "deoxyuridine:phosphate deoxy-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.23]
synonym: "deoxyuridine:phosphate deoxy-D-ribosyltransferase activity" EXACT [EC:2.4.2.23]
xref: EC:2.4.2.23
xref: MetaCyc:DEOXYURIDINE-PHOSPHORYLASE-RXN
xref: RHEA:22827
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0047848
name: dephospho-[reductase kinase] kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] = ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]." [EC:2.7.11.3, MetaCyc:DEPHOSPHO-REDUCTASE-KINASE-KINASE-RXN]
synonym: "AMP-activated kinase activity" EXACT [EC:2.7.11.3]
synonym: "AMP-activated protein kinase kinase activity" EXACT [EC:2.7.11.3]
synonym: "ATP:dephospho-{hydroxymethylglutaryl-CoA reductase (NADPH)kinase} phosphotransferase activity" EXACT [EC:2.7.11.3]
synonym: "dephospho-reductase kinase kinase activity" EXACT [EC:2.7.11.3]
synonym: "hydroxymethylglutaryl coenzyme A reductase kinase kinase (phosphorylating) activity" EXACT [EC:2.7.11.3]
synonym: "hydroxymethylglutaryl coenzyme A reductase kinase kinase activity" EXACT [EC:2.7.11.3]
synonym: "reductase kinase activity" BROAD [EC:2.7.11.3]
synonym: "reductase kinase kinase activity" EXACT [EC:2.7.11.3]
synonym: "STK30" RELATED [EC:2.7.11.3]
xref: EC:2.7.11.3
xref: MetaCyc:DEPHOSPHO-REDUCTASE-KINASE-KINASE-RXN
is_a: GO:0004672 ! protein kinase activity

[Term]
id: GO:0047849
name: dextransucrase activity
namespace: molecular_function
def: "Catalysis of the reaction: sucrose + 1,6-alpha-D-glucosyl(n) = D-fructose + 1,6-alpha-D-glucosyl(n+1)." [EC:2.4.1.5, MetaCyc:DEXTRANSUCRASE-RXN]
subset: gosubset_prok
synonym: "CEP" RELATED [EC:2.4.1.5]
synonym: "SGE" RELATED [EC:2.4.1.5]
synonym: "sucrose 6-glucosyltransferase activity" EXACT [EC:2.4.1.5]
synonym: "sucrose-1,6-alpha-glucan glucosyltransferase activity" EXACT [EC:2.4.1.5]
synonym: "sucrose:1,6-alpha-D-glucan 6-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.5]
xref: EC:2.4.1.5
xref: MetaCyc:DEXTRANSUCRASE-RXN
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0047850
name: diaminopimelate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: meso-2,6-diaminopimelate + H(2)O + NADP(+) = L-2-amino-6-oxopimelate + H(+) + NADPH + NH(4)(+)." [EC:1.4.1.16, RHEA:13564]
subset: gosubset_prok
synonym: "meso-2,6-diaminoheptanedioate:NADP+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.16]
synonym: "meso-alpha,epsilon-diaminopimelate dehydrogenase activity" EXACT [EC:1.4.1.16]
synonym: "meso-diaminopimelate D-dehydrogenase activity" EXACT [EC:1.4.1.16]
synonym: "meso-diaminopimelate dehydrogenase activity" EXACT [EC:1.4.1.16]
xref: EC:1.4.1.16
xref: KEGG:R02755
xref: MetaCyc:DIAMINOPIMELATE-DEHYDROGENASE-RXN
xref: RHEA:13564
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047851
name: dicarboxylate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + an omega-dicarboxylic acid = AMP + diphosphate + an omega-carboxyacyl-CoA." [EC:6.2.1.23, MetaCyc:DICARBOXYLATE--COA-LIGASE-RXN]
synonym: "carboxylyl-CoA synthetase activity" EXACT [EC:6.2.1.23]
synonym: "omega-dicarboxylate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.23]
xref: EC:6.2.1.23
xref: MetaCyc:DICARBOXYLATE--COA-LIGASE-RXN
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0047852
name: diferric-transferrin reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: transferrin[Fe2+]2 + NAD+ = transferrin[Fe3+]2 + NADH." [EC:1.16.1.2, MetaCyc:DIFFERIC-TRANSFERRIN-REDUCTASE-RXN]
synonym: "diferric transferrin reductase activity" EXACT [EC:1.16.1.2]
synonym: "NADH diferric transferrin reductase activity" EXACT [EC:1.16.1.2]
synonym: "transferrin reductase activity" EXACT [EC:1.16.1.2]
synonym: "transferrin[Fe(II)]2:NAD+ oxidoreductase activity" EXACT [EC:1.16.1.2]
xref: EC:1.16.1.2
xref: MetaCyc:DIFFERIC-TRANSFERRIN-REDUCTASE-RXN
is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor

[Term]
id: GO:0047853
name: difructose-anhydride synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + bis-D-fructose 2',1:2,1'-dianhydride = inulobiose." [EC:3.2.1.134, MetaCyc:DIFRUCTOSE-ANHYDRIDE-SYNTHASE-RXN]
synonym: "bis-D-fructose 2',1:2,1'-dianhydride fructohydrolase activity" EXACT [EC:3.2.1.134]
synonym: "inulobiose hydrolase activity" EXACT [EC:3.2.1.134]
xref: EC:3.2.1.134
xref: MetaCyc:DIFRUCTOSE-ANHYDRIDE-SYNTHASE-RXN
xref: RHEA:15044
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0047854
name: diguanidinobutanase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,4-diguanidinobutane + H(2)O = agmatine + urea." [EC:3.5.3.20, RHEA:13600]
synonym: "1,4-diguanidinobutane amidinohydrolase activity" EXACT [EC:3.5.3.20]
xref: EC:3.5.3.20
xref: KEGG:R01418
xref: MetaCyc:DIGUANIDINOBUTANASE-RXN
xref: RHEA:13600
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0047855
name: dihydrobunolol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: dihydrobunolol + NADP(+) = bunolol + H(+) + NADPH." [EC:1.1.1.160, RHEA:15928]
synonym: "(+-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-1,2,3,4-tetrahydro-1-naphthol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.160]
synonym: "bunolol reductase activity" EXACT [EC:1.1.1.160]
xref: EC:1.1.1.160
xref: KEGG:R04623
xref: MetaCyc:DIHYDROBUNOLOL-DEHYDROGENASE-RXN
xref: RHEA:15928
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047856
name: dihydrocoumarin hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,4-dihydrocoumarin + H(2)O = 3-(2-hydroxyphenyl)propanoate + H(+)." [EC:3.1.1.35, RHEA:10363]
subset: gosubset_prok
synonym: "dihydrocoumarin lactonohydrolase activity" EXACT [EC:3.1.1.35]
synonym: "dihydrocoumarin lipase activity" EXACT []
xref: EC:3.1.1.35
xref: KEGG:R03692
xref: MetaCyc:DIHYDROCOUMARIN-LIPASE-RXN
xref: RHEA:10363
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0047857
name: dihydrouracil oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,6-dihydrouracil + O(2) = H(2)O(2) + uracil." [EC:1.3.3.7, RHEA:12387]
synonym: "5,6-dihydrouracil:oxygen oxidoreductase activity" EXACT [EC:1.3.3.7]
xref: EC:1.3.3.7
xref: KEGG:R00975
xref: MetaCyc:DIHYDROURACIL-OXIDASE-RXN
xref: RHEA:12387
is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor

[Term]
id: GO:0047858
name: dihydroxyfumarate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: dihydroxyfumarate + H(+) = 2-hydroxy-3-oxopropanoate + CO(2)." [EC:4.1.1.54, RHEA:13848]
synonym: "dihydroxyfumarate carboxy-lyase (tartronate-semialdehyde-forming)" EXACT [EC:4.1.1.54]
synonym: "dihydroxyfumarate carboxy-lyase activity" EXACT [EC:4.1.1.54]
xref: EC:4.1.1.54
xref: KEGG:R03127
xref: MetaCyc:DIHYDROXYFUMARATE-DECARBOXYLASE-RXN
xref: RHEA:13848
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047859
name: obsolete dihydroxyphenylalanine ammonia-lyase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3,4-dihydroxy-L-phenylalanine = trans-caffeate + NH3." [EC:4.3.1.11, MetaCyc:DIHYDROXYPHENYLALANINE-AMMONIA-LYASE-RXN]
comment: This term was made obsolete because the corresponding EC reaction has been deleted from the EC.
synonym: "3,4-dihydroxy-L-phenylalanine ammonia-lyase (trans-caffeate-forming)" EXACT [EC:4.3.1.11]
synonym: "3,4-dihydroxy-L-phenylalanine ammonia-lyase activity" EXACT [EC:4.3.1.11]
synonym: "beta-(3,4-dihydroxyphenyl)-L-alanine (DOPA) ammonia-lyase activity" EXACT [EC:4.3.1.11]
synonym: "dihydroxyphenylalanine ammonia-lyase activity" EXACT []
xref: EC:4.3.1.11
is_obsolete: true

[Term]
id: GO:0047860
name: diiodophenylpyruvate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD(+) = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + H(+) + NADH." [EC:1.1.1.96, RHEA:20296]
synonym: "2-oxo acid reductase activity" EXACT [EC:1.1.1.96]
synonym: "3-(3,5-diiodo-4-hydroxyphenyl)lactate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.96]
synonym: "aromatic alpha-keto acid" RELATED [EC:1.1.1.96]
synonym: "KAR" RELATED [EC:1.1.1.96]
xref: EC:1.1.1.96
xref: KEGG:R03431
xref: MetaCyc:DIIODOPHENYLPYRUVATE-REDUCTASE-RXN
xref: RHEA:20296
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047861
name: diiodotyrosine transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + 3,5-diiodo-L-tyrosine = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + L-glutamate." [EC:2.6.1.24, RHEA:19784]
synonym: "3,5-diiodo-L-tyrosine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.24]
synonym: "diiodotyrosine aminotransferase activity" EXACT []
synonym: "halogenated tyrosine aminotransferase activity" EXACT [EC:2.6.1.24]
synonym: "halogenated tyrosine transaminase activity" EXACT [EC:2.6.1.24]
xref: EC:2.6.1.24
xref: KEGG:R03207
xref: MetaCyc:DIIODOTYROSINE-AMINOTRANSFERASE-RXN
xref: RHEA:19784
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047862
name: diisopropyl-fluorophosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: diisopropyl fluorophosphate + H(2)O = diisopropyl phosphate + 2 H(+) + hydrogen fluoride." [EC:3.1.8.2, RHEA:24103]
synonym: "DFPase activity" EXACT [EC:3.1.8.2]
synonym: "dialkylfluorophosphatase activity" EXACT [EC:3.1.8.2]
synonym: "diisopropyl phosphorofluoridate hydrolase activity" EXACT [EC:3.1.8.2]
synonym: "diisopropyl-fluorophosphate fluorohydrolase activity" EXACT [EC:3.1.8.2]
synonym: "diisopropylfluorophosphonate dehalogenase activity" EXACT [EC:3.1.8.2]
synonym: "diisopropylphosphofluoridase activity" EXACT [EC:3.1.8.2]
synonym: "isopropylphosphorofluoridase activity" EXACT [EC:3.1.8.2]
synonym: "OPA anhydrase activity" EXACT [EC:3.1.8.2]
synonym: "OPAA activity" EXACT [EC:3.1.8.2]
synonym: "organophosphate acid anhydrase activity" EXACT [EC:3.1.8.2]
synonym: "organophosphorus acid anhydrolase activity" EXACT [EC:3.1.8.2]
synonym: "somanase activity" EXACT [EC:3.1.8.2]
synonym: "tabunase activity" EXACT [EC:3.1.8.2]
xref: EC:3.1.8.2
xref: KEGG:R01533
xref: MetaCyc:DIISOPROPYL-FLUOROPHOSPHATASE-RXN
xref: RHEA:24103
is_a: GO:0016795 ! phosphoric triester hydrolase activity

[Term]
id: GO:0047863
name: dimethylallylcistransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + neryl diphosphate." [EC:2.5.1.28, RHEA:11331]
synonym: "dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallylcistransferase activity" EXACT [EC:2.5.1.28]
synonym: "neryl-diphosphate synthase activity" EXACT [EC:2.5.1.28]
xref: EC:2.5.1.28
xref: KEGG:R01659
xref: MetaCyc:DIMETHYLALLYLCISTRANSFERASE-RXN
xref: RHEA:11331
is_a: GO:0004659 ! prenyltransferase activity

[Term]
id: GO:0047864
name: dimethylaniline-N-oxide aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N,N-dimethylaniline N-oxide = N-methylaniline + formaldehyde." [EC:4.1.2.24, RHEA:19324]
subset: gosubset_prok
synonym: "microsomal N-oxide dealkylase activity" EXACT [EC:4.1.2.24]
synonym: "microsomal oxidase II" RELATED [EC:4.1.2.24]
synonym: "N,N-dimethylaniline-N-oxide formaldehyde-lyase (N-methylaniline-forming)" EXACT [EC:4.1.2.24]
synonym: "N,N-dimethylaniline-N-oxide formaldehyde-lyase activity" EXACT [EC:4.1.2.24]
xref: EC:4.1.2.24
xref: KEGG:R03345
xref: MetaCyc:DIMETHYLANILINE-N-OXIDE-ALDOLASE-RXN
xref: RHEA:19324
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0047865
name: dimethylglycine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: N,N-dimethylglycine + electron-transfer flavoprotein + H2O = sarcosine + formaldehyde + reduced electron-transfer flavoprotein." [EC:1.5.8.4, RHEA:22499]
comment: Note that this was EC:1.5.99.2.
subset: gosubset_prok
synonym: "N,N-dimethylglycine oxidase activity" EXACT [EC:1.5.8.4]
synonym: "N,N-dimethylglycine:(acceptor) oxidoreductase (demethylating)" EXACT [EC:1.5.8.4]
synonym: "N,N-dimethylglycine:acceptor oxidoreductase (demethylating)" EXACT [EC:1.5.8.4]
xref: EC:1.5.8.4
xref: KEGG:R01565
xref: MetaCyc:DIMETHYLGLYCINE-DEHYDROGENASE-RXN
xref: RHEA:22499
is_a: GO:0046997 ! oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor

[Term]
id: GO:0047866
name: dimethylglycine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: N,N-dimethylglycine + H(2)O + O(2) = formaldehyde + H(2)O(2) + sarcosine." [EC:1.5.3.10, RHEA:17080]
synonym: "N,N-dimethylglycine:oxygen oxidoreductase (demethylating)" EXACT [EC:1.5.3.10]
xref: EC:1.5.3.10
xref: KEGG:R01564
xref: MetaCyc:DIMETHYLGLYCINE-OXIDASE-RXN
xref: RHEA:17080
is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor

[Term]
id: GO:0047867
name: dimethylmalate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-3,3-dimethylmalate + NAD(+) = 3-methyl-2-oxobutanoate + CO(2) + NADH." [EC:1.1.1.84, RHEA:13324]
synonym: "(R)-3,3-dimethylmalate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.84]
synonym: "beta,beta-dimethylmalate dehydrogenase activity" EXACT [EC:1.1.1.84]
xref: EC:1.1.1.84
xref: KEGG:R01211
xref: MetaCyc:DIMETHYLMALATE-DEHYDROGENASE-RXN
xref: RHEA:13324
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047868
name: dimethylmaleate hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2R,3S)-2,3-dimethylmalate = dimethylmaleate + H(2)O." [EC:4.2.1.85, RHEA:20256]
synonym: "(2R,3S)-2,3-dimethylmalate hydro-lyase (dimethylmaleate-forming)" EXACT [EC:4.2.1.85]
synonym: "(2R,3S)-2,3-dimethylmalate hydro-lyase activity" EXACT [EC:4.2.1.85]
xref: EC:4.2.1.85
xref: KEGG:R03069
xref: MetaCyc:DIMETHYLMALEATE-HYDRATASE-RXN
xref: RHEA:20256
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047869
name: dimethylpropiothetin dethiomethylase activity
namespace: molecular_function
def: "Catalysis of the reaction: S,S-dimethyl-beta-propiothetin = acrylate + dimethyl sulfide + H(+)." [EC:4.4.1.3, RHEA:19968]
synonym: "desulfhydrase activity" EXACT [EC:4.4.1.3]
synonym: "S,S-dimethyl-beta-propiothetin dimethyl-sulfide-lyase (acrylate-forming)" EXACT [EC:4.4.1.3]
synonym: "S,S-dimethyl-beta-propiothetin dimethyl-sulfide-lyase activity" EXACT [EC:4.4.1.3]
xref: EC:4.4.1.3
xref: KEGG:R02574
xref: MetaCyc:DIMETHYLPROPIOTHETIN-DETHIOMETHYLASE-RXN
xref: RHEA:19968
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0047870
name: discadenine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: N(6)-dimethylallyladenine + S-adenosyl-L-methionine(1+) = S-methyl-5'-thioadenosine + discadenine + H(+)." [EC:2.5.1.24, RHEA:19584]
synonym: "discadenine synthetase activity" EXACT [EC:2.5.1.24]
synonym: "S-adenosyl-L-methionine:6-N-(Delta2-isopentenyl)-adenine 3-(3-amino-3-carboxypropyl)-transferase activity" EXACT [EC:2.5.1.24]
synonym: "S-adenosyl-L-methionine:N6-(Delta2-isopentenyl)-adenine 3-(3-amino-3-carboxypropyl)-transferas" RELATED [EC:2.5.1.24]
xref: EC:2.5.1.24
xref: KEGG:R03726
xref: MetaCyc:DISCADENINE-SYNTHASE-RXN
xref: RHEA:19584
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0047871
name: disulfoglucosamine-6-sulfatase activity
namespace: molecular_function
def: "Catalysis of the reaction: N(2),6-disulfo-D-glucosamine + H(2)O = N-sulfo-D-glucosamine + H(+) + sulfate." [EC:3.1.6.11, RHEA:15520]
synonym: "6,N-disulfoglucosamine 6-O-sulfohydrolase activity" EXACT [EC:3.1.6.11]
synonym: "disulphoglucosamine-6-sulphatase activity" EXACT []
synonym: "N,6-O-disulfo-D-glucosamine 6-sulfohydrolase activity" EXACT [EC:3.1.6.11]
synonym: "N-sulfoglucosamine-6-sulfatase activity" EXACT [EC:3.1.6.11]
xref: EC:3.1.6.11
xref: KEGG:R03216
xref: MetaCyc:DISULFOGLUCOSAMINE-6-SULFATASE-RXN
xref: RHEA:15520
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0047872
name: dolichol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: palmitoyl-CoA + dolichol = CoA + dolichyl palmitate." [EC:2.3.1.123, MetaCyc:DOLICHOL-O-ACYLTRANSFERASE-RXN]
synonym: "acyl-CoA:dolichol acyltransferase activity" EXACT [EC:2.3.1.123]
synonym: "palmitoyl-CoA:dolichol O-palmitoyltransferase activity" EXACT [EC:2.3.1.123]
xref: EC:2.3.1.123
xref: MetaCyc:DOLICHOL-O-ACYLTRANSFERASE-RXN
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0047873
name: dolichyl-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: dolichyl phosphate + H2O = dolichol + phosphate." [EC:3.1.3.51, MetaCyc:DOLICHYL-PHOSPHATASE-RXN]
synonym: "Dol-P phosphatase activity" EXACT [EC:3.1.3.51]
synonym: "Dol-P-P phosphohydrolase activity" EXACT []
synonym: "dolichol monophosphatase activity" EXACT [EC:3.1.3.51]
synonym: "dolichol phosphatase activity" EXACT [EC:3.1.3.51]
synonym: "dolichol phosphate phosphatase activity" EXACT [EC:3.1.3.51]
synonym: "dolichyl monophosphate phosphatase activity" EXACT [EC:3.1.3.51]
synonym: "dolichyl phosphate phosphatase activity" EXACT [EC:3.1.3.51]
synonym: "dolichyl pyrophosphate phosphatase activity" EXACT []
synonym: "dolichyl-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.51]
synonym: "polyisoprenyl phosphate phosphatase activity" EXACT [EC:3.1.3.51]
synonym: "polyprenylphosphate phosphatase activity" EXACT [EC:3.1.3.51]
xref: EC:3.1.3.51
xref: MetaCyc:DOLICHYL-PHOSPHATASE-RXN
xref: RHEA:13800
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0047874
name: dolichyldiphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: dolichyl diphosphate + H2O = dolichyl phosphate + phosphate." [EC:3.6.1.43, MetaCyc:DOLICHYLDIPHOSPHATASE-RXN]
synonym: "dolichol diphosphatase activity" EXACT [EC:3.6.1.43]
synonym: "dolichyl diphosphate phosphohydrolase activity" EXACT [EC:3.6.1.43]
synonym: "dolichyl pyrophosphatase activity" EXACT [EC:3.6.1.43]
synonym: "dolichyl-diphosphate phosphohydrolase activity" EXACT [EC:3.6.1.43]
xref: EC:3.6.1.43
xref: MetaCyc:DOLICHYLDIPHOSPHATASE-RXN
xref: Reactome:REACT_22114 "Dephosphorylation of dolichyl diphosphate, Homo sapiens"
xref: RHEA:14388
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0047875
name: ecdysone oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: Ecdysone + O(2) = 3-dehydroecdysone + H(2)O(2)." [EC:1.1.3.16, RHEA:11799]
synonym: "beta-ecdysone oxidase activity" EXACT [EC:1.1.3.16]
synonym: "ecdysone:oxygen 3-oxidoreductase activity" EXACT [EC:1.1.3.16]
xref: EC:1.1.3.16
xref: KEGG:R02373
xref: MetaCyc:ECDYSONE-OXIDASE-RXN
xref: RHEA:11799
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0047876
name: endoglycosylceramidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + oligoglycosylglucosylceramide = ceramide + oligoglycosylglucose." [EC:3.2.1.123, MetaCyc:ENDOGLYCOSYLCERAMIDASE-RXN]
subset: gosubset_prok
synonym: "EGCase activity" EXACT [EC:3.2.1.123]
synonym: "endo-glucosylceramidase activity" EXACT [EC:3.2.1.123]
synonym: "endoglycoceramidase activity" EXACT [EC:3.2.1.123]
synonym: "glycosyl-N-acetyl-sphingosine 1,1-beta-D-glucanohydrolase activity" EXACT [EC:3.2.1.123]
synonym: "oligoglycosylglucosylceramide glycohydrolase activity" EXACT [EC:3.2.1.123]
xref: EC:3.2.1.123
xref: MetaCyc:ENDOGLYCOSYLCERAMIDASE-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0047877
name: ephedrine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (1R,2S)-ephedrine + NAD(+) = (R)-2-methylimino-1-phenylpropan-1-ol + 2 H(+) + NADH." [EC:1.5.1.18, RHEA:16292]
synonym: "(-)-ephedrine:NAD+ 2-oxidoreductase activity" EXACT [EC:1.5.1.18]
xref: EC:1.5.1.18
xref: KEGG:R03614
xref: MetaCyc:EPHEDRINE-DEHYDROGENASE-RXN
xref: RHEA:16292
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047878
name: erythritol kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + erythritol = D-erythritol 4-phosphate + ADP + 2 H(+)." [EC:2.7.1.27, RHEA:20711]
subset: gosubset_prok
synonym: "ATP:erythritol 4-phosphotransferase activity" EXACT [EC:2.7.1.27]
synonym: "erythritol kinase (phosphorylating)" EXACT [EC:2.7.1.27]
xref: EC:2.7.1.27
xref: KEGG:R02430
xref: MetaCyc:ERYTHRITOL-KINASE-RXN
xref: RHEA:20711
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047879
name: erythronolide synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6 malonyl-CoA + propionyl-CoA = 7 CoA + 6-deoxyerythronolide B." [EC:2.3.1.94, MetaCyc:ERYTHRONOLIDE-SYNTHASE-RXN]
subset: gosubset_prok
synonym: "erythronolide condensing enzyme activity" EXACT [EC:2.3.1.94]
synonym: "malonyl-CoA:propionyl-CoA malonyltransferase (cyclizing)" EXACT [EC:2.3.1.94]
xref: EC:2.3.1.94
xref: MetaCyc:ERYTHRONOLIDE-SYNTHASE-RXN
xref: RHEA:23071
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0047880
name: erythrulose reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-threitol + NADP(+) = D-erythrulose + H(+) + NADPH." [EC:1.1.1.162, RHEA:18008]
synonym: "D-erythrulose reductase activity" EXACT [EC:1.1.1.162]
synonym: "erythritol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.162]
xref: EC:1.1.1.162
xref: KEGG:R08573
xref: MetaCyc:ERYTHRULOSE-REDUCTASE-RXN
xref: RHEA:18008
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047881
name: estradiol 17-alpha-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: estradiol-17-alpha + NAD(P)+ = estrone + NAD(P)H + H+." [EC:1.1.1.148, MetaCyc:ESTRADIOL-17-ALPHA-DEHYDROGENASE-RXN]
synonym: "17alpha-estradiol dehydrogenase activity" EXACT [EC:1.1.1.148]
synonym: "17alpha-hydroxy steroid dehydrogenase activity" EXACT [EC:1.1.1.148]
synonym: "17alpha-hydroxy steroid oxidoreductase activity" EXACT [EC:1.1.1.148]
synonym: "17alpha-hydroxysteroid oxidoreductase activity" EXACT [EC:1.1.1.148]
synonym: "17alpha-hydroxysteroid:NAD(P)+ 17-oxidoreductase activity" EXACT [EC:1.1.1.148]
synonym: "estradiol 17a-dehydrogenase activity" EXACT []
synonym: "estradiol 17alpha-dehydrogenase activity" EXACT [EC:1.1.1.148]
synonym: "estradiol 17alpha-oxidoreductase activity" EXACT [EC:1.1.1.148]
xref: EC:1.1.1.148
xref: MetaCyc:ESTRADIOL-17-ALPHA-DEHYDROGENASE-RXN
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047882
name: estradiol 6-beta-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: AH(2) + estradiol-17beta + O(2) = 6beta-hydroxyestradiol-17beta + A + H(2)O." [EC:1.14.99.11, RHEA:19140]
synonym: "estradiol 6-beta-hydroxylase activity" EXACT [EC:1.14.99.11]
synonym: "estradiol 6b-hydroxylase activity" EXACT []
synonym: "estradiol 6b-monooxygenase activity" EXACT []
synonym: "estradiol 6beta-hydroxylase activity" EXACT [EC:1.14.99.11]
synonym: "estradiol 6beta-monooxygenase activity" EXACT [EC:1.14.99.11]
synonym: "estradiol-17beta,hydrogen-donor:oxygen oxidoreductase (6beta-hydroxylating)" EXACT [EC:1.14.99.11]
xref: EC:1.14.99.11
xref: KEGG:R03086
xref: MetaCyc:ESTRADIOL-6-BETA-MONOOXYGENASE-RXN
xref: RHEA:19140
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0047883
name: ethanolamine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: ethanolamine + H2O + O2 = glycolaldehyde + NH3 + H2O2." [EC:1.4.3.8, MetaCyc:ETHANOLAMINE-OXIDASE-RXN]
synonym: "ethanolamine:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.8]
xref: EC:1.4.3.8
xref: MetaCyc:ETHANOLAMINE-OXIDASE-RXN
xref: RHEA:18584
is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

[Term]
id: GO:0047884
name: FAD diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: FAD + H2O = AMP + FMN." [EC:3.6.1.18, MetaCyc:FAD-PYROPHOSPHATASE-RXN]
synonym: "FAD nucleotidohydrolase activity" EXACT [EC:3.6.1.18]
synonym: "FAD pyrophosphatase activity" EXACT []
synonym: "FAD pyrophosphohydrolase activity" EXACT [GOC:tb]
synonym: "flavin adenine dinucleotide pyrophosphatase activity" EXACT [EC:3.6.1.18]
synonym: "flavine adenine dinucleotide pyrophosphatase activity" EXACT [EC:3.6.1.18]
synonym: "riboflavin adenine dinucleotide pyrophosphatase activity" EXACT [EC:3.6.1.18]
synonym: "riboflavine adenine dinucleotide pyrophosphatase activity" EXACT [EC:3.6.1.18]
xref: EC:3.6.1.18
xref: MetaCyc:FAD-PYROPHOSPHATASE-RXN
xref: RHEA:13892
is_a: GO:0004551 ! nucleotide diphosphatase activity

[Term]
id: GO:0047885
name: farnesol 2-isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesol = 2-cis,6-trans-farnesol." [EC:5.2.1.9, RHEA:13404]
subset: gosubset_prok
synonym: "2-trans,6-trans-farnesol 2-cis-trans-isomerase activity" EXACT [EC:5.2.1.9]
synonym: "farnesol isomerase activity" EXACT [EC:5.2.1.9]
xref: EC:5.2.1.9
xref: KEGG:R03265
xref: MetaCyc:FARNESOL-2-ISOMERASE-RXN
xref: RHEA:13404
is_a: GO:0016859 ! cis-trans isomerase activity

[Term]
id: GO:0047886
name: farnesol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesol + NADP(+) = 2-trans,6-trans-farnesal + H(+) + NADPH." [EC:1.1.1.216, RHEA:14700]
synonym: "2-trans,6-trans-farnesol:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.216]
synonym: "farnesol (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT [EC:1.1.1.216]
synonym: "NADP-farnesol dehydrogenase activity" EXACT [EC:1.1.1.216]
xref: EC:1.1.1.216
xref: KEGG:R03264
xref: MetaCyc:FARNESOL-DEHYDROGENASE-RXN
xref: RHEA:14700
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047887
name: farnesyl diphosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + ATP = 2-trans,6-trans-farnesyl triphosphate + ADP." [EC:2.7.4.18, RHEA:21547]
synonym: "ATP:farnesyl-diphosphate phosphotransferase activity" EXACT [EC:2.7.4.18]
synonym: "farnesyl pyrophosphate kinase activity" EXACT [EC:2.7.4.18]
synonym: "farnesyl-diphosphate kinase activity" EXACT []
xref: EC:2.7.4.18
xref: KEGG:R02303
xref: MetaCyc:FARNESYL-DIPHOSPHATE-KINASE-RXN
xref: RHEA:21547
is_a: GO:0016301 ! kinase activity
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor

[Term]
id: GO:0047888
name: fatty acid peroxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 H(2)O(2) + H(+) + palmitate = CO(2) + 3 H(2)O + pentadecanal." [EC:1.11.1.3, RHEA:23963]
synonym: "fatty-acid peroxidase activity" EXACT []
synonym: "hexadecanoate:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.3]
synonym: "long chain fatty acid peroxidase activity" EXACT [EC:1.11.1.3]
xref: EC:1.11.1.3
xref: KEGG:R01703
xref: MetaCyc:FATTY-ACID-PEROXIDASE-RXN
xref: RHEA:23963
is_a: GO:0004601 ! peroxidase activity

[Term]
id: GO:0047889
name: ferredoxin-nitrate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: nitrite + H2O + 2 oxidized ferredoxin = nitrate + 2 reduced ferredoxin." [EC:1.7.7.2, MetaCyc:FERREDOXIN--NITRATE-REDUCTASE-RXN]
synonym: "assimilatory ferredoxin-nitrate reductase activity" EXACT [EC:1.7.7.2]
synonym: "assimilatory nitrate reductase activity" BROAD [EC:1.7.7.2]
synonym: "nitrate (ferredoxin) reductase activity" EXACT [EC:1.7.7.2]
synonym: "nitrite:ferredoxin oxidoreductase activity" EXACT [EC:1.7.7.2]
xref: EC:1.7.7.2
xref: MetaCyc:1.7.7.2-RXN
is_a: GO:0016664 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulfur protein as acceptor

[Term]
id: GO:0047890
name: flavanone 4-reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2S)-flavan-4-ol + NADP+ = (2S)-flavanone + NADPH." [EC:1.1.1.234, MetaCyc:FLAVANONE-4-REDUCTASE-RXN]
synonym: "(2S)-flavan-4-ol:NADP+ 4-oxidoreductase activity" EXACT [EC:1.1.1.234]
synonym: "flavonone 4-reductase activity" EXACT []
xref: EC:1.1.1.234
xref: MetaCyc:FLAVANONE-4-REDUCTASE-RXN
xref: RHEA:11231
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047891
name: flavone 7-O-beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + 5,7,3',4'-tetrahydroxyflavone = UDP + 7-O-beta-D-glucosyl-5,7,3',4'-tetrahydroxyflavone." [EC:2.4.1.81, MetaCyc:FLAVONE-7-O-BETA-GLUCOSYLTRANSFERASE-RXN]
synonym: "flavone 7-O-b-glucosyltransferase activity" EXACT []
synonym: "UDP-glucose-apigenin beta-glucosyltransferase activity" EXACT [EC:2.4.1.81]
synonym: "UDP-glucose-luteolin beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.81]
synonym: "UDP-glucose:5,7,3',4'-tetrahydroxyflavone 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.81]
synonym: "UDPglucose-apigenin beta-glucosyltransferase activity" EXACT [EC:2.4.1.81]
synonym: "UDPglucose-luteolin beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.81]
synonym: "UDPglucose:5,7,3',4'-tetrahydroxyflavone 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.81]
synonym: "uridine diphosphoglucose-apigenin 7-O-glucosyltransferase activity" EXACT [EC:2.4.1.81]
synonym: "uridine diphosphoglucose-luteolin glucosyltransferase activity" EXACT [EC:2.4.1.81]
xref: EC:2.4.1.81
xref: MetaCyc:FLAVONE-7-O-BETA-GLUCOSYLTRANSFERASE-RXN
xref: RHEA:19580
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047892
name: flavone apiosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-apiose + 7-O-beta-D-glucosyl-5,7,4'-trihydroxyflavone = UDP + 7-O-(beta-D-apiofuranosyl-1,2-beta-D-glucosyl)-5,7,4'-trihydroxyflavone." [EC:2.4.2.25, MetaCyc:FLAVONE-APIOSYLTRANSFERASE-RXN]
synonym: "UDP-apiose:5,4'-dihydroxyflavone 7-O-beta-D-glucoside 2''-O-beta-D-apiofuranosyltransferase activity" EXACT [EC:2.4.2.25]
synonym: "UDP-apiose:7-O-(beta-D-glucosyl)-flavone apiosyltransferase activity" EXACT [EC:2.4.2.25]
synonym: "uridine diphosphoapiose-flavone apiosyltransferase activity" EXACT [EC:2.4.2.25]
xref: EC:2.4.2.25
xref: MetaCyc:FLAVONE-APIOSYLTRANSFERASE-RXN
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0047893
name: flavonol 3-O-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + a flavonol = UDP + a flavonol 3-O-D-glucoside." [EC:2.4.1.91, MetaCyc:FLAVONOL-3-O-GLUCOSYLTRANSFERASE-RXN]
synonym: "GTI" RELATED [EC:2.4.1.91]
synonym: "UDP-glucose flavonol 3-O-glucosyltransferase activity" EXACT [EC:2.4.1.91]
synonym: "UDP-glucose:flavonol 3-O-D-glucosyltransferase activity" EXACT [EC:2.4.1.91]
synonym: "UDP-glucose:flavonol 3-O-glucosyltransferase activity" EXACT [EC:2.4.1.91]
synonym: "UDPG:flavonoid-3-O-glucosyltransferase activity" EXACT [EC:2.4.1.91]
synonym: "UDPglucose:flavonol 3-O-D-glucosyltransferase activity" EXACT [EC:2.4.1.91]
synonym: "uridine diphosphoglucose-flavonol 3-O-glucosyltransferase activity" EXACT [EC:2.4.1.91]
xref: EC:2.4.1.91
xref: MetaCyc:FLAVONOL-3-O-GLUCOSYLTRANSFERASE-RXN
xref: RHEA:22303
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047894
name: flavonol 3-sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + quercetin = adenosine 3',5'-diphosphate + H(+) + quercetin 3-sulfate." [EC:2.8.2.25, RHEA:13456]
subset: goslim_chembl
synonym: "3'-phosphoadenylyl-sulfate:quercetin 3-sulfotransferase activity" EXACT systematic_synonym [EC:2.8.2.25]
synonym: "flavonol 3-sulphotransferase activity" EXACT []
xref: EC:2.8.2.25
xref: KEGG:R02159
xref: MetaCyc:FLAVONOL-3-SULFOTRANSFERASE-RXN
xref: RHEA:13456
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0047895
name: formaldehyde dismutase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 formaldehyde + H2O = methanol + formate." [EC:1.2.99.4, MetaCyc:FORMALDEHYDE-DISMUTASE-RXN]
synonym: "aldehyde dismutase activity" EXACT [EC:1.2.99.4]
synonym: "cannizzanase activity" EXACT [EC:1.2.99.4]
synonym: "formaldehyde:formaldehyde oxidoreductase activity" EXACT [EC:1.2.99.4]
synonym: "nicotinoprotein aldehyde dismutase" EXACT [EC:1.2.99.4]
xref: EC:1.2.99.4
xref: MetaCyc:FORMALDEHYDE-DISMUTASE-RXN
xref: RHEA:19224
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0047896
name: formaldehyde transketolase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-xylulose 5-phosphate + formaldehyde = glyceraldehyde 3-phosphate + glycerone." [EC:2.2.1.3, MetaCyc:FORMALDEHYDE-TRANSKETOLASE-RXN]
synonym: "D-xylulose-5-phosphate:formaldehyde glycolaldehydetransferase activity" EXACT [EC:2.2.1.3]
synonym: "DHAS activity" EXACT [EC:2.2.1.3]
synonym: "dihydroxyacetone synthase activity" EXACT [EC:2.2.1.3]
synonym: "glycerone synthase activity" EXACT [EC:2.2.1.3]
xref: EC:2.2.1.3
xref: MetaCyc:FORMALDEHYDE-TRANSKETOLASE-RXN
xref: RHEA:24267
is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups

[Term]
id: GO:0047897
name: formate-dihydrofolate ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7,8-dihydrofolate + ATP + formate = 10-formyldihydrofolate + ADP + H(+) + phosphate." [EC:6.3.4.17, RHEA:24331]
synonym: "dihydrofolate formyltransferase activity" EXACT [EC:6.3.4.17]
synonym: "formate:dihydrofolate ligase (ADP-forming)" EXACT [EC:6.3.4.17]
synonym: "formyl dihydrofolate synthase activity" EXACT [EC:6.3.4.17]
xref: EC:6.3.4.17
xref: KEGG:R02238
xref: MetaCyc:FORMATE--DIHYDROFOLATE-LIGASE-RXN
xref: RHEA:24331
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0047898
name: formate dehydrogenase (cytochrome) activity
namespace: molecular_function
def: "Catalysis of the reaction: formate + ferricytochrome b1 = CO2 + ferrocytochrome b1." [EC:1.2.2.1, MetaCyc:FORMATE-DEHYDROGENASE-CYTOCHROME-RXN]
synonym: "formate:cytochrome b1 oxidoreductase activity" EXACT [EC:1.2.2.1]
synonym: "formate:ferricytochrome-b1 oxidoreductase activity" EXACT [EC:1.2.2.1]
xref: EC:1.2.2.1
xref: MetaCyc:FORMATE-DEHYDROGENASE-CYTOCHROME-RXN
is_a: GO:0016622 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor

[Term]
id: GO:0047899
name: formate dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: formate + NADP(+) = CO(2) + NADPH." [EC:1.2.1.43, RHEA:12003]
subset: gosubset_prok
synonym: "formate:NADP+ oxidoreductase activity" EXACT [EC:1.2.1.43]
synonym: "NADP-dependent formate dehydrogenase activity" EXACT [EC:1.2.1.43]
xref: EC:1.2.1.43
xref: KEGG:R00134
xref: MetaCyc:FORMATE-DEHYDROGENASE-NADP+-RXN
xref: RHEA:12003
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047900
name: formate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + formate = ADP + formyl phosphate + H(+)." [EC:2.7.2.6, RHEA:16012]
synonym: "ATP:formate phosphotransferase activity" EXACT [EC:2.7.2.6]
xref: EC:2.7.2.6
xref: KEGG:R00518
xref: MetaCyc:FORMATE-KINASE-RXN
xref: RHEA:16012
is_a: GO:0016301 ! kinase activity
is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor

[Term]
id: GO:0047901
name: formyl-CoA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: formyl-CoA + H(2)O = CoA + formate + H(+)." [EC:3.1.2.10, RHEA:19744]
synonym: "formyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.10]
xref: EC:3.1.2.10
xref: KEGG:R00521
xref: MetaCyc:FORMYL-COA-HYDROLASE-RXN
xref: RHEA:19744
is_a: GO:0016289 ! CoA hydrolase activity

[Term]
id: GO:0047902
name: formylaspartate deformylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-formyl-L-aspartate + H2O = formate + L-aspartate." [EC:3.5.1.8, MetaCyc:FORMYLASPARTATE-DEFORMYLASE-RXN]
synonym: "formylaspartic formylase (formylase I, formylase II)" EXACT [EC:3.5.1.8]
synonym: "N-formyl-L-aspartate amidohydrolase activity" EXACT [EC:3.5.1.8]
xref: EC:3.5.1.8
xref: MetaCyc:FORMYLASPARTATE-DEFORMYLASE-RXN
xref: RHEA:22043
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047903
name: fructose 5-dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-fructose + NADP+ = 5-dehydro-D-fructose + NADPH." [EC:1.1.1.124, MetaCyc:FRUCTOSE-5-DEHYDROGENASE-NADP+-RXN]
subset: gosubset_prok
synonym: "5-keto-D-fructose reductase (NADP+)" EXACT [EC:1.1.1.124]
synonym: "5-ketofructose reductase (NADP(+)) activity" EXACT [EC:1.1.1.124]
synonym: "5-ketofructose reductase (NADP)" EXACT [EC:1.1.1.124]
synonym: "5-ketofructose reductase (NADP+) activity" EXACT [EC:1.1.1.124]
synonym: "D-(-)fructose:(NADP+) 5-oxidoreductase activity" EXACT [EC:1.1.1.124]
synonym: "D-fructose:NADP+ 5-oxidoreductase activity" EXACT [EC:1.1.1.124]
synonym: "fructose 5-(nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT [EC:1.1.1.124]
xref: EC:1.1.1.124
xref: MetaCyc:FRUCTOSE-5-DEHYDROGENASE-NADP+-RXN
xref: RHEA:14072
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047904
name: fructose 5-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-fructose + A = 5-dehydro-D-fructose + AH(2)." [EC:1.1.99.11, RHEA:22307]
synonym: "D-fructose dehydrogenase activity" EXACT [EC:1.1.99.11]
synonym: "D-fructose:(acceptor) 5-oxidoreductase activity" EXACT [EC:1.1.99.11]
synonym: "D-fructose:acceptor 5-oxidoreductase activity" EXACT [EC:1.1.99.11]
synonym: "fructose 5-dehydrogenase (acceptor)" EXACT [EC:1.1.99.11]
xref: EC:1.1.99.11
xref: KEGG:R00873
xref: MetaCyc:FRUCTOSE-5-DEHYDROGENASE-RXN
xref: RHEA:22307
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0047905
name: fructose-6-phosphate phosphoketolase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-fructose 6-phosphate + phosphate = acetyl phosphate + D-erythrose 4-phosphate + H2O." [EC:4.1.2.22, MetaCyc:FRUCTOSE-6-PHOSPHATE-PHOSPHOKETOLASE-RXN]
subset: gosubset_prok
synonym: "D-fructose-6-phosphate D-erythrose-4-phosphate-lyase (adding phosphate; acetyl-phosphate-forming)" EXACT [EC:4.1.2.22]
synonym: "D-fructose-6-phosphate D-erythrose-4-phosphate-lyase (phosphate-acetylating) activity" EXACT [EC:4.1.2.22]
xref: EC:4.1.2.22
xref: MetaCyc:FRUCTOSE-6-PHOSPHATE-PHOSPHOKETOLASE-RXN
xref: RHEA:12199
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0047906
name: fucosterol-epoxide lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: (24R,24'R)-fucosterol epoxide = acetaldehyde + desmosterol." [EC:4.1.2.33, RHEA:10887]
synonym: "(24R,24'R)-fucosterol-epoxide acetaldehyde-lyase (desmosterol-forming)" EXACT [EC:4.1.2.33]
synonym: "(24R,24'R)-fucosterol-epoxide acetaldehyde-lyase activity" EXACT [EC:4.1.2.33]
xref: EC:4.1.2.33
xref: KEGG:R03723
xref: MetaCyc:FUCOSTEROL-EPOXIDE-LYASE-RXN
xref: RHEA:10887
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0047907
name: furylfuramide isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: (E)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide = (Z)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide." [EC:5.2.1.6, RHEA:21851]
synonym: "2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide cis-trans-isomerase activity" EXACT [EC:5.2.1.6]
xref: EC:5.2.1.6
xref: KEGG:R04538
xref: MetaCyc:FURYLFURAMIDE-ISOMERASE-RXN
xref: RHEA:21851
is_a: GO:0016859 ! cis-trans isomerase activity

[Term]
id: GO:0047908
name: fusarinine-C ornithinesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: N5-acyl-L-ornithine ester + H2O = N5-acyl-L-ornithine + an alcohol." [EC:3.1.1.48, MetaCyc:FUSARININE-C-ORNITHINESTERASE-RXN]
synonym: "5-N-acyl-L-ornithine-ester hydrolase activity" EXACT [EC:3.1.1.48]
synonym: "N5-acyl-L-ornithine-ester hydrolase activity" EXACT [EC:3.1.1.48]
synonym: "ornithine esterase activity" EXACT [EC:3.1.1.48]
xref: EC:3.1.1.48
xref: MetaCyc:FUSARININE-C-ORNITHINESTERASE-RXN
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0047909
name: galactolipid O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 mono-beta-D-galactosyldiacylglycerol = acylmono-beta-D-galactosyl-diacylglycerol + mono-beta-D-galactosylacylglycerol." [EC:2.3.1.134, MetaCyc:GALACTOLIPID-O-ACYLTRANSFERASE-RXN]
synonym: "galactolipid:galactolipid acyltransferase activity" EXACT [EC:2.3.1.134]
synonym: "mono-beta-D-galactosyldiacylglycerol:mono-beta-D-galactosyldiacylglycerol acyltransferase activity" EXACT [EC:2.3.1.134]
xref: EC:2.3.1.134
xref: MetaCyc:GALACTOLIPID-O-ACYLTRANSFERASE-RXN
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0047910
name: galactose 1-dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-galactose + NADP+ = D-galactonolactone + NADPH." [EC:1.1.1.120, MetaCyc:GALACTOSE-1-DEHYDROGENASE-NADP+-RXN]
synonym: "D-galactose dehydrogenase (NADP+)" EXACT [EC:1.1.1.120]
synonym: "D-galactose:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.120]
xref: EC:1.1.1.120
xref: MetaCyc:GALACTOSE-1-DEHYDROGENASE-NADP+-RXN
xref: RHEA:18628
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047911
name: galacturan 1,4-alpha-galacturonidase activity
namespace: molecular_function
def: "Catalysis of the reaction: [(1->4)-alpha-D-galacturonide](n) + H2O = [(1->4)-alpha-D-galacturonide](n-1) + D-galacturonate." [EC:3.2.1.67, MetaCyc:GALACTURAN-14-ALPHA-GALACTURONIDASE-RXN]
synonym: "exo-D-galacturonanase activity" EXACT [EC:3.2.1.67]
synonym: "exo-D-galacturonase activity" EXACT []
synonym: "exo-polygalacturonase activity" EXACT []
synonym: "exopoly-D-galacturonase activity" EXACT []
synonym: "exopolygalacturonase activity" EXACT [EC:3.2.1.67]
synonym: "galacturan alpha-1,4-galacturonidase activity" EXACT []
synonym: "poly(1,4-alpha-D-galacturonide) galacturonohydrolase activity" EXACT [EC:3.2.1.67]
synonym: "poly(galacturonate) hydrolase activity" EXACT [EC:3.2.1.67]
xref: EC:3.2.1.67
xref: MetaCyc:GALACTURAN-14-ALPHA-GALACTURONIDASE-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0047912
name: galacturonokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-galacturonate + ATP = 1-phospho-alpha-D-galacturonate + ADP + 2 H(+)." [EC:2.7.1.44, RHEA:12968]
synonym: "ATP:D-galacturonate 1-phosphotransferase activity" EXACT [EC:2.7.1.44]
synonym: "galacturonokinase (phosphorylating) D-galacturonic acid kinase activity" EXACT [EC:2.7.1.44]
xref: EC:2.7.1.44
xref: KEGG:R01980
xref: MetaCyc:GALACTURONOKINASE-RXN
xref: RHEA:12968
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047913
name: gallate 1-beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: gallate + UDP-D-glucose = 1-O-galloyl-beta-D-glucose + UDP." [EC:2.4.1.136, RHEA:15252]
synonym: "gallate 1-b-glucosyltransferase activity" EXACT []
synonym: "UDP-glucose-vanillate 1-glucosyltransferase activity" EXACT [EC:2.4.1.136]
synonym: "UDP-glucose:gallate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.136]
synonym: "UDPglucose-vanillate 1-glucosyltransferase activity" EXACT [EC:2.4.1.136]
synonym: "UDPglucose:gallate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.136]
synonym: "UDPglucose:gallate glucosyltransferase activity" EXACT [EC:2.4.1.136]
synonym: "UDPglucose:vanillate 1-O-glucosyltransferase activity" EXACT [EC:2.4.1.136]
xref: EC:2.4.1.136
xref: KEGG:R03297
xref: MetaCyc:GALLATE-1-BETA-GLUCOSYLTRANSFERASE-RXN
xref: RHEA:15252
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047914
name: gamma-glutamylhistamine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: histamine + L-glutamate + ATP = N(alpha)-gamma-L-glutamylhistamine + products of ATP breakdown." [EC:6.3.2.18, MetaCyc:GAMMA-GLUTAMYLHISTAMINE-SYNTHASE-RXN]
synonym: "g-glutamylhistamine synthase activity" EXACT []
synonym: "gamma-GHA synthetase activity" EXACT [EC:6.3.2.18]
synonym: "gamma-glutaminylhistamine synthetase activity" EXACT [EC:6.3.2.18]
synonym: "L-glutamate:histamine ligase activity" EXACT [EC:6.3.2.18]
xref: EC:6.3.2.18
xref: MetaCyc:GAMMA-GLUTAMYLHISTAMINE-SYNTHASE-RXN
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0047915
name: ganglioside galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-galactose + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-1,4-beta-D-glucosyl-N-acylsphingosine = UDP + D-galactosyl-1,3-beta-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine." [EC:2.4.1.62, MetaCyc:GANGLIOSIDE-GALACTOSYLTRANSFERASE-RXN]
synonym: "GM1-synthase activity" EXACT [EC:2.4.1.62]
synonym: "UDP galactose-LAC Tet-ceramide alpha-galactosyltransferase activity" EXACT [EC:2.4.1.62]
synonym: "UDP-galactose-GM2 galactosyltransferase activity" EXACT [EC:2.4.1.62]
synonym: "UDP-galactose-GM2 ganglioside galactosyltransferase activity" EXACT [EC:2.4.1.62]
synonym: "UDP-galactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine beta-1,3-D-galactosyltransferase activity" EXACT [EC:2.4.1.62]
synonym: "UDP-galactose:N-acetylgalactosaminyl-(N-acetylneuraminyl) galactosyl-glucosyl-ceramide galactosyltransferase activity" EXACT [EC:2.4.1.62]
synonym: "UDPgalactose-ceramide galactosyltransferase activity" EXACT [EC:2.4.1.62]
synonym: "UDPgalactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine beta-1,3-D-galactosyltransferase activity" EXACT [EC:2.4.1.62]
synonym: "uridine diphosphate D-galactose:glycolipid galactosyltransferase activity" EXACT [EC:2.4.1.62]
synonym: "uridine diphosphogalactose-ceramide galactosyltransferase activity" EXACT [EC:2.4.1.62]
synonym: "uridine diphosphogalactose-GM2 galactosyltransferase activity" EXACT [EC:2.4.1.62]
xref: EC:2.4.1.62
xref: MetaCyc:GANGLIOSIDE-GALACTOSYLTRANSFERASE-RXN
xref: RHEA:16776
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0047916
name: GDP-6-deoxy-D-talose 4-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-6-deoxy-D-talose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-talose + NAD(P)H + H+." [EC:1.1.1.135, MetaCyc:GDP-6-DEOXY-D-TALOSE-4-DEHYDROGENASE-RXN]
synonym: "GDP-6-deoxy-D-talose:NAD(P)+ 4-oxidoreductase activity" EXACT [EC:1.1.1.135]
synonym: "guanosine diphospho-6-deoxy-D-talose dehydrogenase activity" EXACT [EC:1.1.1.135]
xref: EC:1.1.1.135
xref: MetaCyc:GDP-6-DEOXY-D-TALOSE-4-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047917
name: GDP-glucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-D-glucose + H(2)O = D-glucose + GDP + H(+)." [EC:3.2.1.42, RHEA:15052]
synonym: "GDP-glucose glucohydrolase activity" EXACT [EC:3.2.1.42]
synonym: "GDPglucose glucohydrolase activity" EXACT [EC:3.2.1.42]
synonym: "GDPglucosidase activity" EXACT [EC:3.2.1.42]
synonym: "guanosine diphosphate D-glucose glucohydrolase activity" EXACT [EC:3.2.1.42]
synonym: "guanosine diphosphoglucosidase activity" EXACT [EC:3.2.1.42]
xref: EC:3.2.1.42
xref: KEGG:R00337
xref: MetaCyc:GDP-GLUCOSIDASE-RXN
xref: RHEA:15052
is_a: GO:0015926 ! glucosidase activity

[Term]
id: GO:0047918
name: GDP-mannose 3,5-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-mannose = GDP-L-galactose." [EC:5.1.3.18]
synonym: "GDP-D-mannose:GDP-L-galactose epimerase activity" EXACT [EC:5.1.3.18]
synonym: "GDPmannose 3,5-epimerase activity" EXACT [EC:5.1.3.18]
synonym: "guanosine 5'-diphosphate D-mannose:guanosine 5'-diphosphate L-galactose epimerase activity" EXACT [EC:5.1.3.18]
xref: EC:5.1.3.18
xref: MetaCyc:RXN-1882
xref: RHEA:11147
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0047919
name: GDP-mannose 6-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-alpha-D-mannose + H(2)O + 2 NAD(+) = GDP-D-mannuronate + 3 H(+) + 2 NADH." [EC:1.1.1.132, RHEA:21731]
subset: gosubset_prok
synonym: "GDP mannose dehydrogenase activity" EXACT [EC:1.1.1.132]
synonym: "GDP-D-mannose:NAD+ 6-oxidoreductase activity" EXACT [EC:1.1.1.132]
synonym: "GDPmannose 6-dehydrogenase activity" EXACT [EC:1.1.1.132]
synonym: "guanosine diphospho-D-mannose dehydrogenase activity" EXACT [EC:1.1.1.132]
synonym: "guanosine diphosphomannose dehydrogenase activity" EXACT [EC:1.1.1.132]
xref: EC:1.1.1.132
xref: KEGG:R00880
xref: MetaCyc:GDP-MANNOSE-6-DEHYDROGENASE-RXN
xref: RHEA:21731
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047920
name: geissoschizine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: geissoschizine + NADP(+) = 4,21-dehydrogeissoschizine + H(+) + NADPH." [EC:1.3.1.36, RHEA:11379]
synonym: "geissoschizine:NADP+ 4,21-oxidoreductase activity" EXACT [EC:1.3.1.36]
xref: EC:1.3.1.36
xref: KEGG:R03860
xref: MetaCyc:GEISSOSCHIZINE-DEHYDROGENASE-RXN
xref: RHEA:11379
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047921
name: aminoglycoside 2'-N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + gentamicin C(1a) = N(2')-acetylgentamicin C(1a) + CoA + H(+). This is acetylation of the 2'-amino group of the 6-deoxy-6-aminoglucose ring." [EC:2.3.1.59, RHEA:24519]
synonym: "acetyl-CoA:gentamicin-C1a N2'-acetyltransferase activity" NARROW [EC:2.3.1.59]
synonym: "acetyl-CoA:gentamycin-C1a N2'-acetyltransferase activity" NARROW [EC:2.3.1.59]
synonym: "gentamicin 2'-N-acetyltransferase activity" NARROW []
synonym: "gentamicin acetyltransferase II activity" NARROW [EC:2.3.1.59]
synonym: "gentamycin 2'-N-acetyltransferase activity" NARROW []
synonym: "gentamycin acetyltransferase II" RELATED [EC:2.3.1.59]
xref: EC:2.3.1.59
xref: KEGG:R03056
xref: MetaCyc:GENTAMICIN-2-N-ACETYLTRANSFERASE-RXN
xref: RHEA:24519
is_a: GO:0034069 ! aminoglycoside N-acetyltransferase activity

[Term]
id: GO:0047922
name: gentisate 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,5-dihydroxybenzoate + O(2) = 3-maleylpyruvate + H(+)." [EC:1.13.11.4, RHEA:18240]
subset: gosubset_prok
synonym: "2,5-dihydroxybenzoate dioxygenase activity" EXACT [EC:1.13.11.4]
synonym: "gentisate dioxygenase activity" EXACT [EC:1.13.11.4]
synonym: "gentisate oxygenase activity" EXACT [EC:1.13.11.4]
synonym: "gentisate:oxygen 1,2-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.4]
synonym: "gentisic acid oxidase activity" EXACT [EC:1.13.11.4]
xref: EC:1.13.11.4
xref: KEGG:R02656
xref: MetaCyc:GENTISATE-12-DIOXYGENASE-RXN
xref: RHEA:18240
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0047923
name: gentisate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,5-dihydroxybenzoate + H(+) = CO(2) + hydroquinone." [EC:4.1.1.62, RHEA:21315]
synonym: "2,5-dihydroxybenzoate carboxy-lyase (hydroquinone-forming)" EXACT [EC:4.1.1.62]
synonym: "2,5-dihydroxybenzoate decarboxylase activity" EXACT [EC:4.1.1.62]
synonym: "gentisate carboxy-lyase activity" EXACT [EC:4.1.1.62]
xref: EC:4.1.1.62
xref: KEGG:R02489
xref: MetaCyc:GENTISATE-DECARBOXYLASE-RXN
xref: RHEA:21315
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047924
name: geraniol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: geraniol + NADP+ = geranial + NADPH." [EC:1.1.1.183, MetaCyc:GERANIOL-DEHYDROGENASE-RXN]
synonym: "geraniol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.183]
xref: EC:1.1.1.183
xref: MetaCyc:GERANIOL-DEHYDROGENASE-RXN
xref: RHEA:14524
xref: UM-BBD_reactionID:r1163
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047925
name: geranoyl-CoA carboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + bicarbonate + geranoyl-CoA = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + ADP + 2 H(+) + phosphate." [EC:6.4.1.5, RHEA:17704]
synonym: "geranoyl coenzyme A carboxylase activity" EXACT [EC:6.4.1.5]
synonym: "geranoyl-CoA:carbon-dioxide ligase (ADP-forming)" EXACT [EC:6.4.1.5]
synonym: "geranyl-CoA carboxylase activity" EXACT [EC:6.4.1.5]
xref: EC:6.4.1.5
xref: KEGG:R03494
xref: MetaCyc:GERANOYL-COA-CARBOXYLASE-RXN
xref: RHEA:17704
xref: UM-BBD_reactionID:r1166
is_a: GO:0016421 ! CoA carboxylase activity

[Term]
id: GO:0047926
name: geranyl-diphosphate cyclase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranyl diphosphate = (2S)-bornyl diphosphate." [EC:5.5.1.8, RHEA:18212]
synonym: "(+)-bornyl-diphosphate lyase (decyclizing)" EXACT [EC:5.5.1.8]
synonym: "(+)-bornylpyrophosphate cyclase activity" EXACT [EC:5.5.1.8]
synonym: "bornyl diphosphate synthase activity" EXACT [EC:5.5.1.8]
synonym: "bornyl pyrophosphate synthase activity" EXACT [EC:5.5.1.8]
synonym: "bornyl pyrophosphate synthetase activity" EXACT [EC:5.5.1.8]
xref: EC:5.5.1.8
xref: KEGG:R02007
xref: MetaCyc:GERANYL-DIPHOSPHATE-CYCLASE-RXN
xref: RHEA:18212
is_a: GO:0009975 ! cyclase activity
is_a: GO:0016872 ! intramolecular lyase activity

[Term]
id: GO:0047927
name: gibberellin-44 dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: gibberellin 44 + 2-oxoglutarate + O2 = gibberellin 19 + succinate + CO2." [EC:1.14.11.12, MetaCyc:GIBBERELLIN-44-DIOXYGENASE-RXN]
synonym: "(gibberellin-44), 2-oxoglutarate:oxygen oxidoreductase activity" EXACT [EC:1.14.11.12]
synonym: "(gibberellin-44),2-oxoglutarate:oxygen oxidoreductase activity" EXACT [EC:1.14.11.12]
synonym: "gibberellin A44 oxidase activity" EXACT [EC:1.14.11.12]
synonym: "oxygenase, gibberellin A44 oxidase activity" EXACT [EC:1.14.11.12]
xref: EC:1.14.11.12
xref: MetaCyc:RXN1F-168
xref: RHEA:16036
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0047928
name: gibberellin beta-D-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + gibberellin = UDP + gibberellin 2-O-beta-D-glucoside." [EC:2.4.1.176, MetaCyc:GIBBERELLIN-BETA-GLUCOSYLTRANSFERASE-RXN]
synonym: "gibberellin b-glucosyltransferase activity" EXACT []
synonym: "UDP-glucose:gibberellin 2-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.176]
synonym: "UDPglucose:gibberellin 2-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.176]
synonym: "uridine diphosphoglucose-gibberellate 3-O-glucosyltransferase activity" EXACT [EC:2.4.1.176]
synonym: "uridine diphosphoglucose-gibberellate 7-glucosyltransferase activity" EXACT [EC:2.4.1.176]
xref: EC:2.4.1.176
xref: MetaCyc:GIBBERELLIN-BETA-GLUCOSYLTRANSFERASE-RXN
xref: RHEA:20028
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047929
name: gluconate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-gluconate = 2-dehydro-3-deoxy-D-gluconate + H(2)O." [EC:4.2.1.39, RHEA:21615]
subset: gosubset_prok
synonym: "D-gluconate dehydratase activity" EXACT [EC:4.2.1.39]
synonym: "D-gluconate hydro-lyase (2-dehydro-3-deoxy-D-gluconate-forming)" EXACT [EC:4.2.1.39]
synonym: "D-gluconate hydro-lyase activity" EXACT [EC:4.2.1.39]
xref: EC:4.2.1.39
xref: KEGG:R01538
xref: MetaCyc:GLUCONATE-DEHYDRATASE-RXN
xref: RHEA:21615
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047930
name: glucosaminate ammonia-lyase activity
namespace: molecular_function
alt_id: GO:0050443
def: "Catalysis of the reaction: D-glucosaminate = 2-dehydro-3-deoxy-D-gluconate + NH3." [EC:4.3.1.9, MetaCyc:GLUCOSAMINATE-AMMONIA-LYASE-RXN]
comment: Note that this function was EC:4.3.1.21.
synonym: "2-amino-2-deoxy-D-gluconate ammonia-lyase activity" EXACT [EC:4.3.1.9]
synonym: "2-amino-2-deoxy-D-gluconate hydro-lyase (deaminating) activity" EXACT [EC:4.3.1.9]
synonym: "acetylenemonocarboxylic acid hydrase activity" EXACT [EC:4.3.1.9]
synonym: "aminodeoxygluconate ammonia-lyase activity" EXACT []
synonym: "aminodeoxygluconate dehydratase activity" EXACT []
synonym: "D-glucosaminate ammonia-lyase (isomerizing; 2-dehydro-3-deoxy-D-gluconate-forming)" EXACT [EC:4.3.1.9]
synonym: "D-glucosaminate ammonia-lyase activity" EXACT [EC:4.3.1.9]
synonym: "D-glucosaminate dehydratase activity" EXACT [EC:4.3.1.9]
synonym: "D-glucosaminic acid dehydrase activity" EXACT [EC:4.3.1.9]
synonym: "glucosaminic dehydrase activity" EXACT [EC:4.3.1.9]
xref: EC:4.3.1.9
xref: MetaCyc:4.3.1.21-RXN
xref: RHEA:12491
is_a: GO:0016841 ! ammonia-lyase activity

[Term]
id: GO:0047931
name: glucosamine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-glucosamine = ADP + D-glucosamine phosphate." [EC:2.7.1.8, MetaCyc:GLUCOSAMINE-KINASE-RXN]
synonym: "aminodeoxyglucose kinase activity" EXACT [EC:2.7.1.8]
synonym: "ATP:2-amino-2-deoxy-D-glucose-6-phosphotransferase activity" EXACT [EC:2.7.1.8]
synonym: "ATP:D-glucosamine phosphotransferase activity" EXACT [EC:2.7.1.8]
synonym: "glucosamine kinase (phosphorylating)" EXACT [EC:2.7.1.8]
xref: EC:2.7.1.8
xref: MetaCyc:GLUCOSAMINE-KINASE-RXN
xref: RHEA:10951
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047932
name: glucosamine N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucosamine + acetyl-CoA = N-acetyl-D-glucosamine + CoA + H(+)." [EC:2.3.1.3, RHEA:21335]
synonym: "acetyl-CoA:D-glucosamine N-acetyltransferase activity" EXACT [EC:2.3.1.3]
synonym: "glucosamine acetylase activity" EXACT [EC:2.3.1.3]
synonym: "glucosamine acetyltransferase activity" EXACT [EC:2.3.1.3]
xref: EC:2.3.1.3
xref: KEGG:R01204
xref: MetaCyc:GLUCOSAMINE-N-ACETYLTRANSFERASE-RXN
xref: RHEA:21335
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0047933
name: glucose-1,6-bisphosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate + alpha-D-glucose 1-phosphate = 3-phospho-D-glycerate + alpha-D-glucose 1,6-bisphosphate + H(+)." [EC:2.7.1.106, RHEA:16772]
synonym: "3-phospho-D-glyceroyl-phosphate:alpha-D-glucose-1-phosphate 6-phosphotransferase activity" EXACT [EC:2.7.1.106]
synonym: "3-phospho-D-glyceroyl-phosphate:D-glucose-1-phosphate 6-phosphotransferase activity" EXACT [EC:2.7.1.106]
synonym: "glucose 1,6-diphosphate synthase activity" EXACT [EC:2.7.1.106]
synonym: "glucose-1,6-bisphosphate synthetase activity" EXACT [EC:2.7.1.106]
xref: EC:2.7.1.106
xref: KEGG:R01660
xref: MetaCyc:GLUCOSE-16-BISPHOSPHATE-SYNTHASE-RXN
xref: RHEA:16772
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047934
name: glucose 1-dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucose + NAD+ = D-glucono-1,5-lactone + NADH." [EC:1.1.1.118, MetaCyc:GLUCOSE-1-DEHYDROGENASE-NAD+-RXN]
synonym: "D-aldohexose dehydrogenase activity" EXACT [EC:1.1.1.118]
synonym: "D-glucose:NAD oxidoreductase activity" EXACT [EC:1.1.1.118]
synonym: "D-glucose:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.118]
xref: EC:1.1.1.118
xref: MetaCyc:GLUCOSE-1-DEHYDROGENASE-NAD+-RXN
xref: RHEA:14296
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047935
name: glucose 1-dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucose + NADP+ = D-glucono-1,4-lactone + NADPH." [EC:1.1.1.119, MetaCyc:GLUCOSE-1-DEHYDROGENASE-NADP+-RXN]
synonym: "D-glucose:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.119]
synonym: "NADP-dependent glucose dehydrogenase activity" EXACT [EC:1.1.1.119]
synonym: "NADP-linked aldohexose dehydrogenase activity" EXACT [EC:1.1.1.119]
synonym: "nicotinamide adenine dinucleotide phosphate-linked aldohexose dehydrogenase activity" EXACT [EC:1.1.1.119]
xref: EC:1.1.1.119
xref: MetaCyc:GLUCOSE-1-DEHYDROGENASE-NADP+-RXN
xref: RHEA:14408
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047936
name: glucose 1-dehydrogenase [NAD(P)] activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-D-glucose + NAD(P)+ = D-glucono-1,5-lactone + NAD(P)H." [EC:1.1.1.47, MetaCyc:GLUCOSE-1-DEHYDROGENASE-RXN]
subset: gosubset_prok
synonym: "beta-D-glucose:NAD(P)+ 1-oxidoreductase activity" EXACT [EC:1.1.1.47]
synonym: "D-glucose dehydrogenase (NAD(P))" EXACT [EC:1.1.1.47]
synonym: "hexose phosphate dehydrogenase activity" EXACT [EC:1.1.1.47]
xref: EC:1.1.1.47
xref: MetaCyc:GLUCOSE-1-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047937
name: glucose-1-phosphate phosphodismutase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 D-glucose 1-phosphate = D-glucose + D-glucose 1,6-bisphosphate." [EC:2.7.1.41, MetaCyc:GLUCOSE-1-PHOSPHATE-PHOSPHODISMUTASE-RXN]
subset: gosubset_prok
synonym: "D-glucose-1-phosphate:D-glucose-1-phosphate 6-phosphotransferase activity" EXACT [EC:2.7.1.41]
synonym: "glucose 1-phosphate transphosphorylase activity" EXACT [EC:2.7.1.41]
synonym: "phosphodismutase activity" EXACT [EC:2.7.1.41]
xref: EC:2.7.1.41
xref: MetaCyc:GLUCOSE-1-PHOSPHATE-PHOSPHODISMUTASE-RXN
xref: RHEA:16400
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047938
name: glucose-6-phosphate 1-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate." [EC:5.1.3.15, MetaCyc:GLUCOSE-6-PHOSPHATE-1-EPIMERASE-RXN]
synonym: "D-glucose-6-phosphate 1-epimerase activity" EXACT [EC:5.1.3.15]
synonym: "glucose-6 phosphate 1-epimerase activity" EXACT []
xref: EC:5.1.3.15
xref: MetaCyc:GLUCOSE-6-PHOSPHATE-1-EPIMERASE-RXN
xref: RHEA:16252
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0047939
name: L-glucuronate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-gulonate + NADP(+) = D-glucuronate + H(+) + NADPH." [EC:1.1.1.19, RHEA:14912]
synonym: "aldehyde reductase II activity" RELATED [EC:1.1.1.19]
synonym: "D-glucuronate dehydrogenase activity" EXACT [EC:1.1.1.19]
synonym: "D-glucuronate reductase activity" NARROW [EC:1.1.1.19]
synonym: "glucuronate dehydrogenase activity" EXACT [EC:1.1.1.19]
synonym: "glucuronate reductase activity" EXACT []
synonym: "NADP-L-gulonate dehydrogenase activity" EXACT [EC:1.1.1.19]
synonym: "TPN-L-gulonate dehydrogenase activity" EXACT [EC:1.1.1.19]
xref: EC:1.1.1.19
xref: KEGG:R01481
xref: MetaCyc:GLUCURONATE-REDUCTASE-RXN
xref: RHEA:14912
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047940
name: glucuronokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucuronate + ATP = 1-phospho-alpha-D-glucuronate + ADP + 2 H(+)." [EC:2.7.1.43, RHEA:17008]
synonym: "ATP:D-glucuronate 1-phosphotransferase activity" EXACT [EC:2.7.1.43]
synonym: "glucurono-glucuronokinase activity" EXACT [EC:2.7.1.43]
synonym: "glucuronokinase (phosphorylating)" EXACT [EC:2.7.1.43]
xref: EC:2.7.1.43
xref: KEGG:R01476
xref: MetaCyc:GLUCURONOKINASE-RXN
xref: RHEA:17008
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047941
name: glucuronolactone reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-gulono-1,4-lactone + NADP(+) = D-glucurono-3,6-lactone + H(+) + NADPH." [EC:1.1.1.20, RHEA:18928]
subset: gosubset_prok
xref: EC:1.1.1.20
xref: KEGG:R03183
xref: MetaCyc:GLUCURONOLACTONE-REDUCTASE-RXN
xref: RHEA:18928
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047942
name: glutamate-ethylamine ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamate + ATP + ethylamine = N(5)-ethyl-L-glutamine + ADP + 2 H(+) + phosphate." [EC:6.3.1.6, RHEA:20528]
synonym: "L-glutamate:ethylamine ligase (ADP-forming)" EXACT [EC:6.3.1.6]
synonym: "N(5)-ethyl-L-glutamine synthetase activity" EXACT [EC:6.3.1.6]
synonym: "N5-ethyl-L-glutamine synthetase activity" EXACT [EC:6.3.1.6]
synonym: "N5-ethylglutamine synthetase activity" EXACT [EC:6.3.1.6]
synonym: "theanine synthetase activity" EXACT [EC:6.3.1.6]
xref: EC:6.3.1.6
xref: KEGG:R02929
xref: MetaCyc:GLUTAMATE--ETHYLAMINE-LIGASE-RXN
xref: RHEA:20528
is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity

[Term]
id: GO:0047943
name: glutamate-methylamine ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamate + ATP + methylammonium = N(5)-methyl-L-glutamine + ADP + 2 H(+) + phosphate." [EC:6.3.4.12, RHEA:17120]
synonym: "gamma-glutamylmethylamide synthetase activity" EXACT [EC:6.3.4.12]
synonym: "L-glutamate:methylamine ligase (ADP-forming)" EXACT [EC:6.3.4.12]
xref: EC:6.3.4.12
xref: KEGG:R01585
xref: MetaCyc:GLUTAMATE--METHYLAMINE-LIGASE-RXN
xref: RHEA:17120
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0047944
name: glutamate 1-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamate + ATP = alpha-L-glutamyl phosphate + ADP + H(+)." [EC:2.7.2.13, RHEA:17220]
synonym: "ATP:L-glutamate 1-phosphotransferase activity" EXACT [EC:2.7.2.13]
xref: EC:2.7.2.13
xref: KEGG:R00241
xref: MetaCyc:GLUTAMATE-1-KINASE-RXN
xref: RHEA:17220
is_a: GO:0016301 ! kinase activity
is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor

[Term]
id: GO:0047945
name: L-glutamine:pyruvate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamine + pyruvate = 2-oxoglutaramate + L-alanine." [EC:2.6.1.15, RHEA:10403]
subset: gosubset_prok
synonym: "gamma-glutaminyltransferase activity" RELATED [EC:2.6.1.15]
synonym: "glutaminase II activity" RELATED [EC:2.6.1.15]
synonym: "glutamine transaminase activity" BROAD [EC:2.6.1.15]
synonym: "glutamine transaminase L activity" BROAD [EC:2.6.1.15]
synonym: "glutamine--oxo-acid transaminase activity" BROAD [EC:2.6.1.15]
synonym: "glutamine--pyruvate aminotransferase activity" BROAD []
synonym: "glutamine-alpha-keto acid transamidase activity" BROAD [EC:2.6.1.15]
synonym: "glutamine-alpha-keto acid transaminase activity" BROAD [EC:2.6.1.15]
synonym: "glutamine-keto acid aminotransferase activity" BROAD [EC:2.6.1.15]
synonym: "glutamine-oxo acid aminotransferase activity" BROAD [EC:2.6.1.15]
synonym: "glutamine-pyruvate transaminase activity" BROAD [EC:2.6.1.15]
synonym: "L-glutamine transaminase L" RELATED [EC:2.6.1.15]
xref: EC:2.6.1.15
xref: KEGG:R00576
xref: MetaCyc:GLUTAMINE--PYRUVATE-AMINOTRANSFERASE-RXN
xref: Reactome:REACT_25034 "glutamine + pyruvate => 2-oxoglutaramate + alanine, Homo sapiens"
xref: RHEA:10403
is_a: GO:0070548 ! L-glutamine aminotransferase activity

[Term]
id: GO:0047946
name: glutamine N-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + L-glutamine = CoA + N-acyl-L-glutamine." [EC:2.3.1.68, MetaCyc:GLUTAMINE-N-ACYLTRANSFERASE-RXN]
synonym: "acyl-CoA:L-glutamine N-acyltransferase activity" EXACT [EC:2.3.1.68]
xref: EC:2.3.1.68
xref: MetaCyc:GLUTAMINE-N-ACYLTRANSFERASE-RXN
is_a: GO:0016410 ! N-acyltransferase activity

[Term]
id: GO:0047947
name: glutamine N-phenylacetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenylacetyl-CoA + L-glutamine = CoA + alpha-N-phenylacetyl-L-glutamine." [EC:2.3.1.14, MetaCyc:GLUTAMINE-N-PHENYLACETYLTRANSFERASE-RXN]
synonym: "glutamine phenylacetyltransferase activity" EXACT [EC:2.3.1.14]
synonym: "phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase activity" EXACT [EC:2.3.1.14]
synonym: "phenylacetyl-CoA:L-glutamine N-acetyltransferase activity" EXACT [EC:2.3.1.14]
xref: EC:2.3.1.14
xref: MetaCyc:GLUTAMINE-N-PHENYLACETYLTRANSFERASE-RXN
xref: RHEA:21847
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0047948
name: glutarate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + CoA + glutarate = ADP + glutaryl-CoA + H(+) + phosphate." [EC:6.2.1.6, RHEA:14172]
synonym: "glutarate:CoA ligase (ADP-forming)" EXACT [EC:6.2.1.6]
synonym: "glutaryl coenzyme A synthetase activity" EXACT [EC:6.2.1.6]
synonym: "glutaryl-CoA synthetase activity" EXACT [EC:6.2.1.6]
xref: EC:6.2.1.6
xref: KEGG:R02402
xref: MetaCyc:GLUTARATE--COA-LIGASE-RXN
xref: RHEA:14172
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0047949
name: glutarate-semialdehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: glutarate semialdehyde + NAD+ + H2O = glutarate + NADH." [EC:1.2.1.20, MetaCyc:GLUTARATE-SEMIALDEHYDE-DEHYDROGENASE-RXN]
synonym: "glutarate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.20]
synonym: "glutarate-semialdehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.20]
xref: EC:1.2.1.20
xref: MetaCyc:GLUTARATE-SEMIALDEHYDE-DEHYDROGENASE-RXN
xref: RHEA:12067
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047950
name: glutathione oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 glutathione + O(2) = glutathione disulfide + H(2)O(2)." [EC:1.8.3.3, RHEA:24115]
synonym: "glutathione:oxygen oxidoreductase activity" EXACT [EC:1.8.3.3]
xref: EC:1.8.3.3
xref: KEGG:R00120
xref: MetaCyc:GLUTATHIONE-OXIDASE-RXN
xref: RHEA:24115
is_a: GO:0016670 ! oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor

[Term]
id: GO:0047951
name: glutathione thiolesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-acylglutathione + H(2)O = a carboxylate + glutathione + H(+)." [EC:3.1.2.7, RHEA:22711]
synonym: "citryl-glutathione thioesterhydrolase activity" EXACT [EC:3.1.2.7]
synonym: "glutathione thioesterase activity" EXACT []
synonym: "S-acylglutathione hydrolase activity" EXACT [EC:3.1.2.7]
xref: EC:3.1.2.7
xref: KEGG:R00547
xref: MetaCyc:GLUTATHIONE-THIOESTERASE-RXN
xref: RHEA:22711
is_a: GO:0016790 ! thiolester hydrolase activity

[Term]
id: GO:0047952
name: glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
namespace: molecular_function
def: "Catalysis of the reaction: sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H + H+." [EC:1.1.1.94, MetaCyc:GLYC3PDEHYDROGBIOSYN-RXN]
subset: gosubset_prok
synonym: "glycerol 3-phosphate dehydrogenase (NAD(P)) activity" EXACT [EC:1.1.1.94]
synonym: "glycerol 3-phosphate dehydrogenase (NADP) activity" EXACT [EC:1.1.1.94]
synonym: "glycerol phosphate dehydrogenase (nicotinamide adenine dinucleotide (phosphate)) activity" EXACT [EC:1.1.1.94]
synonym: "glycerol-3-phosphate dehydrogenase (NAD(P)+) activity" EXACT []
synonym: "L-glycerol-3-phosphate:NAD(P) oxidoreductase activity" EXACT [EC:1.1.1.94]
synonym: "sn-glycerol-3-phosphate:NAD(P)+ 2-oxidoreductase activity" EXACT [EC:1.1.1.94]
xref: EC:1.1.1.94
xref: MetaCyc:GLYC3PDEHYDROGBIOSYN-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047953
name: glycerol 2-dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: glycerol + NADP(+) = glycerone + H(+) + NADPH." [EC:1.1.1.156, RHEA:12756]
synonym: "DHA oxidoreductase activity" EXACT [EC:1.1.1.156]
synonym: "dihydroxyacetone (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.1.1.156]
synonym: "dihydroxyacetone reductase (NADPH)" EXACT [EC:1.1.1.156]
synonym: "dihydroxyacetone reductase activity" EXACT [EC:1.1.1.156]
synonym: "glycerol:NADP+ 2-oxidoreductase (glycerone-forming)" EXACT [EC:1.1.1.156]
xref: EC:1.1.1.156
xref: KEGG:R01039
xref: MetaCyc:GLYCEROL-2-DEHYDROGENASE-NADP+-RXN
xref: RHEA:12756
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047954
name: glycerol-2-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycerol 2-phosphate + H(2)O = glycerol + phosphate." [EC:3.1.3.19, RHEA:13108]
synonym: "2-glycerophosphatase activity" EXACT [EC:3.1.3.19]
synonym: "beta-glycerophosphatase activity" EXACT [EC:3.1.3.19]
synonym: "beta-glycerophosphate phosphatase activity" EXACT [EC:3.1.3.19]
synonym: "glycerol-2-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.19]
xref: EC:3.1.3.19
xref: KEGG:R01043
xref: MetaCyc:GLYCEROL-2-PHOSPHATASE-RXN
xref: RHEA:13108
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0047955
name: glycerol dehydrogenase (acceptor) activity
namespace: molecular_function
def: "Catalysis of the reaction: A + glycerol = AH(2) + glycerone." [EC:1.1.99.22, RHEA:17496]
synonym: "glycerol:(acceptor) 1-oxidoreductase activity" EXACT [EC:1.1.99.22]
synonym: "glycerol:acceptor 1-oxidoreductase activity" EXACT [EC:1.1.99.22]
xref: EC:1.1.99.22
xref: KEGG:R01045
xref: MetaCyc:GLYCEROL-DEHYDROGENASE-ACCEPTOR-RXN
xref: RHEA:17496
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0047956
name: glycerol dehydrogenase [NADP+] activity
namespace: molecular_function
def: "Catalysis of the reaction: glycerol + NADP+ = D-glyceraldehyde + NADPH." [EC:1.1.1.72, MetaCyc:GLYCEROL-DEHYDROGENASE-NADP+-RXN]
synonym: "glycerol dehydrogenase (NADP+) activity" RELATED []
synonym: "glycerol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.72]
xref: EC:1.1.1.72
xref: MetaCyc:GLYCEROL-DEHYDROGENASE-NADP+-RXN
xref: RHEA:23595
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047957
name: 4'-methoxyisoflavone 2'-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: formononetin + NADPH + O2 = 2'-hydroxyformononetin + NADP+ + H2O." [EC:1.14.13.53, MetaCyc:ISOFLAVONE-2-HYDROXYLASE-RXN]
synonym: "formononetin,NADPH:oxygen oxidoreductase (2'-hydroxylating)" EXACT [EC:1.14.13.53]
synonym: "isoflavone 2'-monooxygenase activity" BROAD [EC:1.14.13.53]
xref: EC:1.14.13.53
xref: MetaCyc:ISOFLAVONE-2-HYDROXYLASE-RXN
xref: RHEA:12391
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047958
name: glycine:2-oxoglutarate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycine + 2-oxoglutarate = glyoxylate + L-glutamate." [EC:2.6.1.4, MetaCyc:GLYCINE-AMINOTRANSFERASE-RXN]
synonym: "glutamate-glyoxylate transaminase activity" EXACT []
synonym: "glutamic-glyoxylic transaminase activity" EXACT [EC:2.6.1.4]
synonym: "glycine aminotransferase activity" BROAD []
synonym: "glycine transaminase activity" BROAD [EC:2.6.1.4]
synonym: "glyoxylate-glutamate aminotransferase activity" EXACT [EC:2.6.1.4]
synonym: "glyoxylate-glutamic transaminase activity" EXACT [EC:2.6.1.4]
synonym: "L-glutamate:glyoxylate aminotransferase activity" EXACT []
xref: EC:2.6.1.4
xref: MetaCyc:GLYCINE-AMINOTRANSFERASE-RXN
xref: RHEA:14092
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047959
name: glycine dehydrogenase (cytochrome) activity
namespace: molecular_function
def: "Catalysis of the reaction: glycine + H2O + 2 ferricytochrome c = glyoxylate + NH3 + 2 ferrocytochrome c." [EC:1.4.2.1, MetaCyc:GLYCINE-DEHYDROGENASE-CYTOCHROME-RXN]
synonym: "glycine-cytochrome c reductase activity" EXACT [EC:1.4.2.1]
synonym: "glycine:ferricytochrome-c oxidoreductase (deaminating)" EXACT [EC:1.4.2.1]
synonym: "reductase, glycine-cytochrome c" EXACT [EC:1.4.2.1]
xref: EC:1.4.2.1
xref: MetaCyc:GLYCINE-DEHYDROGENASE-CYTOCHROME-RXN
is_a: GO:0016640 ! oxidoreductase activity, acting on the CH-NH2 group of donors, cytochrome as acceptor

[Term]
id: GO:0047960
name: glycine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycine + H2O + NAD+ = glyoxylate + NH3 + NADH." [EC:1.4.1.10, MetaCyc:GLYCINE-DEHYDROGENASE-RXN]
synonym: "glycine:NAD+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.10]
xref: EC:1.4.1.10
xref: MetaCyc:GLYCINE-DEHYDROGENASE-RXN
xref: RHEA:15724
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047961
name: glycine N-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + glycine = CoA + N-acylglycine." [EC:2.3.1.13, MetaCyc:GLYCINE-N-ACYLTRANSFERASE-RXN]
synonym: "acyl-CoA:glycine N-acyltransferase activity" EXACT [EC:2.3.1.13]
synonym: "glycine acyltransferase activity" EXACT [EC:2.3.1.13]
synonym: "glycine-N-acylase activity" EXACT [EC:2.3.1.13]
xref: EC:2.3.1.13
xref: MetaCyc:GLYCINE-N-ACYLTRANSFERASE-RXN
is_a: GO:0016410 ! N-acyltransferase activity

[Term]
id: GO:0047962
name: glycine N-benzoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzoyl-CoA + glycine = N-benzoylglycine + CoA + H(+)." [EC:2.3.1.71, RHEA:18496]
synonym: "benzoyl CoA-amino acid N-acyltransferase activity" EXACT [EC:2.3.1.71]
synonym: "benzoyl-CoA:glycine N-acyltransferase activity" EXACT [EC:2.3.1.71]
synonym: "benzoyl-CoA:glycine N-benzoyltransferase activity" EXACT [EC:2.3.1.71]
xref: EC:2.3.1.71
xref: KEGG:R02452
xref: MetaCyc:GLYCINE-N-BENZOYLTRANSFERASE-RXN
xref: Reactome:REACT_100176 "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A, Sus scrofa"
xref: Reactome:REACT_102524 "salicylate-CoA + glycine => salicyluric acid + Coenzyme A, Mus musculus"
xref: Reactome:REACT_104375 "salicylate-CoA + glycine => salicyluric acid + Coenzyme A, Bos taurus"
xref: Reactome:REACT_107126 "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A, Mus musculus"
xref: Reactome:REACT_109083 "salicylate-CoA + glycine => salicyluric acid + Coenzyme A, Rattus norvegicus"
xref: Reactome:REACT_109892 "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A, Rattus norvegicus"
xref: Reactome:REACT_28340 "salicylate-CoA + glycine => salicyluric acid + Coenzyme A, Canis familiaris"
xref: Reactome:REACT_57774 "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A, Canis familiaris"
xref: Reactome:REACT_6950 "salicylate-CoA + glycine => salicyluric acid + Coenzyme A, Homo sapiens"
xref: Reactome:REACT_6953 "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A, Homo sapiens"
xref: Reactome:REACT_77101 "salicylate-CoA + glycine => salicyluric acid + Coenzyme A, Danio rerio"
xref: Reactome:REACT_81307 "salicylate-CoA + glycine => salicyluric acid + Coenzyme A, Sus scrofa"
xref: Reactome:REACT_89838 "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A, Danio rerio"
xref: Reactome:REACT_95521 "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A, Bos taurus"
xref: RHEA:18496
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0047963
name: glycine N-choloyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: choloyl-CoA + glycine = CoA + glycocholate." [EC:2.3.1.65, MetaCyc:GLYCINE-N-CHOLOYLTRANSFERASE-RXN]
synonym: "amino acid N-choloyltransferase activity" EXACT [EC:2.3.1.65]
synonym: "BACAT activity" EXACT [EC:2.3.1.65]
synonym: "BAT activity" EXACT [EC:2.3.1.65]
synonym: "bile acid-CoA:amino acid N-acyltransferase activity" EXACT [EC:2.3.1.65]
synonym: "choloyl-CoA:glycine N-choloyltransferase activity" EXACT [EC:2.3.1.65]
synonym: "cholyl-CoA glycine-taurine N-acyltransferase activity" EXACT [EC:2.3.1.65]
synonym: "cholyl-CoA:taurine N-acyltransferase activity" EXACT [EC:2.3.1.65]
synonym: "glycine--taurine N-acyltransferase activity" EXACT [EC:2.3.1.65]
xref: EC:2.3.1.65
xref: MetaCyc:GLYCINE-N-CHOLOYLTRANSFERASE-RXN
xref: RHEA:14004
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0047964
name: glyoxylate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycolate + NAD+ = glyoxylate + NADH." [EC:1.1.1.26, MetaCyc:GLYCOLATE-REDUCTASE-RXN]
subset: gosubset_prok
synonym: "glycolate reductase activity" EXACT []
synonym: "glyoxylic acid reductase activity" EXACT [EC:1.1.1.26]
synonym: "NADH-dependent glyoxylate reductase activity" EXACT [EC:1.1.1.26]
xref: EC:1.1.1.26
xref: MetaCyc:GLYCOLATE-REDUCTASE-RXN
xref: RHEA:18232
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047965
name: glycoprotein O-fatty-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: palmitoyl-CoA + mucus glycoprotein = CoA + O-palmitoylglycoprotein." [EC:2.3.1.142, MetaCyc:GLYCOPROTEIN-O-FATTY-ACYLTRANSFERASE-RXN]
synonym: "fatty-acyl-CoA:mucus-glycoprotein fatty-acyltransferase activity" EXACT [EC:2.3.1.142]
synonym: "protein acyltransferase activity" EXACT [EC:2.3.1.142]
xref: EC:2.3.1.142
xref: MetaCyc:GLYCOPROTEIN-O-FATTY-ACYLTRANSFERASE-RXN
is_a: GO:0016416 ! O-palmitoyltransferase activity

[Term]
id: GO:0047966
name: glycosulfatase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucose 6-sulfate + H(2)O = D-glucose + H(+) + sulfate." [EC:3.1.6.3, RHEA:19148]
synonym: "glucosulfatase activity" EXACT [EC:3.1.6.3]
synonym: "glycosulphatase activity" EXACT []
synonym: "sugar-sulfate sulfohydrolase activity" EXACT [EC:3.1.6.3]
xref: EC:3.1.6.3
xref: KEGG:R00534
xref: MetaCyc:GLYCOSULFATASE-RXN
xref: RHEA:19148
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0047967
name: glycyrrhizinate beta-glucuronidase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycyrrhizate + H(2)O = 2-(beta-D-glucuronosyl)-D-glucuronate + glycyrrhetinate." [EC:3.2.1.128, RHEA:17372]
synonym: "glycyrrhizin beta-hydrolase activity" EXACT [EC:3.2.1.128]
synonym: "glycyrrhizin hydrolase activity" EXACT [EC:3.2.1.128]
synonym: "glycyrrhizinate b-glucuronidase activity" EXACT []
synonym: "glycyrrhizinate glucuronosylhydrolase activity" EXACT [EC:3.2.1.128]
synonym: "glycyrrhizinic acid hydrolase activity" EXACT [EC:3.2.1.128]
xref: EC:3.2.1.128
xref: KEGG:R03906
xref: MetaCyc:GLYCYRRHIZINATE-BETA-GLUCURONIDASE-RXN
xref: RHEA:17372
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0047968
name: glyoxylate dehydrogenase (acylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: CoA + glyoxylate + NADP(+) = H(+) + NADPH + oxalyl-CoA." [EC:1.2.1.17, RHEA:21027]
synonym: "glyoxylate:NADP+ oxidoreductase (CoA-oxalylating)" EXACT [EC:1.2.1.17]
xref: EC:1.2.1.17
xref: KEGG:R00468
xref: MetaCyc:GLYOXYLATE-DEHYDROGENASE-ACYLATING-RXN
xref: RHEA:21027
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047969
name: glyoxylate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: glyoxylate + H(2)O + O(2) = H(2)O(2) + H(+) + oxalate." [EC:1.2.3.5, RHEA:14840]
synonym: "glyoxylate:oxygen oxidoreductase activity" EXACT [EC:1.2.3.5]
xref: EC:1.2.3.5
xref: KEGG:R00466
xref: MetaCyc:GLYOXYLATE-OXIDASE-RXN
xref: Reactome:REACT_103094 "Conversion of glyoxylate to oxalate, Canis familiaris"
xref: Reactome:REACT_112040 "Conversion of glyoxylate to oxalate, Dictyostelium discoideum"
xref: Reactome:REACT_112588 "Conversion of glyoxylate to oxalate, Arabidopsis thaliana"
xref: Reactome:REACT_112724 "Conversion of glyoxylate to oxalate, Drosophila melanogaster"
xref: Reactome:REACT_113190 "Conversion of glyoxylate to oxalate, Escherichia coli"
xref: Reactome:REACT_113242 "Conversion of glyoxylate to oxalate, Mycobacterium tuberculosis"
xref: Reactome:REACT_114948 "Conversion of glyoxylate to oxalate, Oryza sativa"
xref: Reactome:REACT_16979 "Conversion of glyoxylate to oxalate, Homo sapiens"
xref: Reactome:REACT_29127 "Conversion of glyoxylate to oxalate, Taeniopygia guttata"
xref: Reactome:REACT_81506 "Conversion of glyoxylate to oxalate, Caenorhabditis elegans"
xref: Reactome:REACT_83110 "Conversion of glyoxylate to oxalate, Danio rerio"
xref: Reactome:REACT_84808 "Conversion of glyoxylate to oxalate, Xenopus tropicalis"
xref: Reactome:REACT_88840 "Conversion of glyoxylate to oxalate, Bos taurus"
xref: Reactome:REACT_89377 "Conversion of glyoxylate to oxalate, Gallus gallus"
xref: Reactome:REACT_90822 "Conversion of glyoxylate to oxalate, Rattus norvegicus"
xref: Reactome:REACT_93529 "Conversion of glyoxylate to oxalate, Mus musculus"
xref: RHEA:14840
is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor

[Term]
id: GO:0047970
name: guanidinoacetase activity
namespace: molecular_function
def: "Catalysis of the reaction: guanidinoacetate + H(2)O = glycine + urea." [EC:3.5.3.2, RHEA:23271]
synonym: "glycocyaminase activity" EXACT [EC:3.5.3.2]
synonym: "guanidinoacetate amidinohydrolase activity" EXACT [EC:3.5.3.2]
xref: EC:3.5.3.2
xref: KEGG:R00775
xref: MetaCyc:GUANIDINOACETASE-RXN
xref: RHEA:23271
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0047971
name: guanidinobutyrase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-guanidinobutanoate + H(2)O = 4-aminobutanoate + urea." [EC:3.5.3.7, RHEA:19504]
subset: gosubset_prok
synonym: "4-guanidinobutanoate amidinohydrolase activity" EXACT [EC:3.5.3.7]
synonym: "4-guanidinobutyrate amidinobutyrase activity" EXACT [EC:3.5.3.7]
synonym: "G-base activity" EXACT [EC:3.5.3.7]
synonym: "gamma-guanidinobutyrate amidinohydrolase activity" EXACT [EC:3.5.3.7]
synonym: "gamma-guanidobutyrase activity" EXACT [EC:3.5.3.7]
synonym: "GBH" RELATED [EC:3.5.3.7]
synonym: "guanidinobutyrate ureahydrolase activity" EXACT [EC:3.5.3.7]
xref: EC:3.5.3.7
xref: KEGG:R01990
xref: MetaCyc:GUANIDINOBUTYRASE-RXN
xref: RHEA:19504
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0047972
name: guanidinopropionase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-guanidinopropanoate + H(2)O = beta-alanine + urea." [EC:3.5.3.17, RHEA:16032]
synonym: "3-guanidinopropanoate amidinopropionase activity" EXACT [EC:3.5.3.17]
synonym: "GPase activity" EXACT [EC:3.5.3.17]
synonym: "GPH" RELATED [EC:3.5.3.17]
xref: EC:3.5.3.17
xref: KEGG:R00913
xref: MetaCyc:GUANIDINOPROPIONASE-RXN
xref: RHEA:16032
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0047973
name: guanidinoacetate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + guanidinoacetate = ADP + 2 H(+) + phosphoguanidinoacetate." [EC:2.7.3.1, RHEA:14148]
synonym: "ATP:guanidinoacetate N-phosphotransferase activity" EXACT [EC:2.7.3.1]
synonym: "glycocyamine kinase activity" EXACT [EC:2.7.3.1]
synonym: "guanidoacetate kinase activity" EXACT []
xref: EC:2.7.3.1
xref: KEGG:R02575
xref: MetaCyc:GUANIDOACETATE-KINASE-RXN
xref: RHEA:14148
is_a: GO:0016301 ! kinase activity
is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor

[Term]
id: GO:0047974
name: guanosine deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: guanosine + H2O = xanthosine + NH3." [EC:3.5.4.15, MetaCyc:GUANOSINE-DEAMINASE-RXN]
synonym: "guanosine aminase activity" EXACT [EC:3.5.4.15]
synonym: "guanosine aminohydrolase activity" EXACT [EC:3.5.4.15]
xref: EC:3.5.4.15
xref: MetaCyc:GUANOSINE-DEAMINASE-RXN
xref: RHEA:12864
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0047975
name: guanosine phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: guanosine + phosphate = guanine + D-ribose 1-phosphate." [EC:2.4.2.15, MetaCyc:GUANPHOSPHOR-RXN]
synonym: "guanosine:phosphate alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.15]
synonym: "guanosine:phosphate D-ribosyltransferase activity" EXACT [EC:2.4.2.15]
xref: EC:2.4.2.15
xref: MetaCyc:GUANPHOSPHOR-RXN
xref: RHEA:13236
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0047976
name: hamamelose kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-hamamelose + ATP = D-hamamelose 2'-phosphate + ADP + 2 H(+)." [EC:2.7.1.102, RHEA:22799]
synonym: "ATP/hamamelose 2'-phosphotransferase activity" EXACT [EC:2.7.1.102]
synonym: "ATP:D-hamamelose 2'-phosphotransferase activity" EXACT [EC:2.7.1.102]
synonym: "hamamelose kinase (phosphorylating)" EXACT [EC:2.7.1.102]
synonym: "hamamelosekinase (ATP: hamamelose 2'-phosphotransferase)" EXACT [EC:2.7.1.102]
xref: EC:2.7.1.102
xref: KEGG:R03766
xref: MetaCyc:HAMAMELOSE-KINASE-RXN
xref: RHEA:22799
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047977
name: hepoxilin-epoxide hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (5Z,9E,14Z)-(8x,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O = (5Z,9E,14Z)-(8x,11x,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate." [EC:3.3.2.7, MetaCyc:HEPOXILIN-EPOXIDE-HYDROLASE-RXN]
synonym: "(5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate hydrolase activity" EXACT [EC:3.3.2.7]
synonym: "hepoxilin A(3) hydrolase activity" RELATED [EC:3.3.2.7]
synonym: "hepoxilin A3 hydrolase activity" EXACT [EC:3.3.2.7]
synonym: "hepoxilin epoxide hydrolase activity" EXACT [EC:3.3.2.7]
synonym: "hepoxylin hydrolase activity" RELATED [EC:3.3.2.7]
xref: EC:3.3.2.7
xref: MetaCyc:HEPOXILIN-EPOXIDE-HYDROLASE-RXN
xref: RHEA:16668
is_a: GO:0016803 ! ether hydrolase activity

[Term]
id: GO:0047978
name: hexadecanol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: hexadecanol + NAD+ = hexadecanal + NADH." [EC:1.1.1.164, MetaCyc:HEXADECANOL-DEHYDROGENASE-RXN]
synonym: "hexadecanol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.164]
xref: EC:1.1.1.164
xref: MetaCyc:HEXADECANOL-DEHYDROGENASE-RXN
xref: RHEA:22059
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047979
name: hexose oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: hexose + O2 = aldono-1,5-lactone + H202." [EC:1.1.3.5, MetaCyc:HEXOSE-OXIDASE-RXN]
synonym: "D-hexose:oxygen 1-oxidoreductase activity" EXACT [EC:1.1.3.5]
xref: EC:1.1.3.5
xref: MetaCyc:HEXOSE-OXIDASE-RXN
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0047980
name: hippurate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-benzoylglycine + H(2)O = benzoate + glycine." [EC:3.5.1.32, RHEA:10427]
subset: gosubset_prok
synonym: "benzoylglycine amidohydrolase activity" EXACT [EC:3.5.1.32]
synonym: "hippuricase activity" EXACT [EC:3.5.1.32]
synonym: "N-benzoylamino-acid amidohydrolase activity" EXACT [EC:3.5.1.32]
xref: EC:3.5.1.32
xref: KEGG:R01424
xref: MetaCyc:HIPPURATE-HYDROLASE-RXN
xref: RHEA:10427
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047981
name: histidine N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-histidine + acetyl-CoA = N(alpha)-acetyl-L-histidine + CoA + H(+)." [EC:2.3.1.33, RHEA:24599]
synonym: "acetyl-CoA:L-histidine N-acetyltransferase activity" EXACT [EC:2.3.1.33]
synonym: "acetylhistidine synthetase activity" EXACT [EC:2.3.1.33]
synonym: "histidine acetyltransferase activity" EXACT [EC:2.3.1.33]
xref: EC:2.3.1.33
xref: KEGG:R01160
xref: MetaCyc:HISTIDINE-N-ACETYLTRANSFERASE-RXN
xref: RHEA:24599
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0047982
name: homocysteine desulfhydrase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-homocysteine + H2O = sulfide + NH3 + 2-oxobutanoate." [EC:4.4.1.2, MetaCyc:HOMOCYSTEINE-DESULFHYDRASE-RXN]
synonym: "homocysteine desulfurase activity" EXACT [EC:4.4.1.2]
synonym: "L-homocysteine hydrogen-sulfide-lyase (deaminating)" EXACT [EC:4.4.1.2]
synonym: "L-homocysteine hydrogen-sulfide-lyase (deaminating; 2-oxobutanoate-forming)" EXACT [EC:4.4.1.2]
xref: EC:4.4.1.2
xref: MetaCyc:HOMOCYSTEINE-DESULFHYDRASE-RXN
xref: Reactome:REACT_116033 "Homocysteine is degraded to oxobutanoate and H2S, Homo sapiens"
xref: RHEA:14504
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0047983
name: homoglutathione synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-alanine + L-gamma-glutamyl-L-cysteine + ATP = gamma-L-glutamyl-L-cysteinyl-beta-alanine + ADP + 2 H(+) + phosphate." [EC:6.3.2.23, RHEA:17996]
synonym: "beta-alanine specific hGSH synthetase activity" EXACT [EC:6.3.2.23]
synonym: "gamma-L-glutamyl-L-cysteine:beta-alanine ligase (ADP-forming)" EXACT [EC:6.3.2.23]
synonym: "homoglutathione synthetase activity" EXACT [EC:6.3.2.23]
xref: EC:6.3.2.23
xref: KEGG:R02741
xref: MetaCyc:HOMOGLUTATHIONE-SYNTHASE-RXN
xref: RHEA:17996
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0047985
name: hydrogen dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2 + NAD+ = H+ + NADH." [EC:1.12.1.2, MetaCyc:HYDROGEN-DEHYDROGENASE-RXN]
subset: gosubset_prok
synonym: "bidirectional hydrogenase activity" BROAD [EC:1.12.1.2]
synonym: "H(2):NAD(+) oxidoreductase activity" EXACT [EC:1.12.1.2]
synonym: "H2:NAD+ oxidoreductase activity" EXACT [EC:1.12.1.2]
synonym: "hydrogen:NAD+ oxidoreductase activity" EXACT [EC:1.12.1.2]
synonym: "hydrogenase activity" BROAD [EC:1.12.1.2]
synonym: "NAD-linked hydrogenase activity" EXACT [EC:1.12.1.2]
xref: EC:1.12.1.2
xref: MetaCyc:HYDROGEN-DEHYDROGENASE-RXN
xref: RHEA:24639
is_a: GO:0016696 ! oxidoreductase activity, acting on hydrogen as donor, NAD or NADP as acceptor

[Term]
id: GO:0047986
name: hydrogen-sulfide S-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + S(2-) = CoA + thioacetate." [EC:2.3.1.10, RHEA:16628]
synonym: "acetyl-CoA:hydrogen-sulfide S-acetyltransferase activity" EXACT [EC:2.3.1.10]
synonym: "hydrogen-sulfide acetyltransferase activity" EXACT [EC:2.3.1.10]
synonym: "hydrogen-sulphide S-acetyltransferase activity" EXACT []
xref: EC:2.3.1.10
xref: KEGG:R01850
xref: MetaCyc:HYDROGEN-SULFIDE-S-ACETYLTRANSFERASE-RXN
xref: RHEA:16628
is_a: GO:0016418 ! S-acetyltransferase activity

[Term]
id: GO:0047987
name: hydroperoxide dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate = (9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate + H2O." [EC:4.2.1.92, MetaCyc:HYDROPEROXIDE-DEHYDRATASE-RXN]
synonym: "(9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate 12,13-hydro-lyase [(9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate-forming]" RELATED [EC:4.2.1.92]
synonym: "(9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate 12,13-hydro-lyase activity" EXACT [EC:4.2.1.92]
synonym: "HPI" RELATED [EC:4.2.1.92]
synonym: "hydroperoxide isomerase activity" EXACT [EC:4.2.1.92]
synonym: "linoleate hydroperoxide isomerase" RELATED [EC:4.2.1.92]
synonym: "linoleic acid hydroperoxide isomerase" RELATED [EC:4.2.1.92]
xref: EC:4.2.1.92
xref: MetaCyc:HYDROPEROXIDE-DEHYDRATASE-RXN
xref: RHEA:25075
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047988
name: hydroxyacid-oxoacid transhydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-3-hydroxybutanoate + 2-oxoglutarate = acetoacetate + (R)-2-hydroxyglutarate." [EC:1.1.99.24, MetaCyc:HYDROXYACID-OXOACID-TRANSHYDROGENASE-RXN]
synonym: "(S)-3-hydroxybutanoate:2-oxoglutarate oxidoreductase activity" EXACT [EC:1.1.99.24]
synonym: "transhydrogenase, hydroxy acid-oxo acid" EXACT [EC:1.1.99.24]
xref: EC:1.1.99.24
xref: MetaCyc:HYDROXYACID-OXOACID-TRANSHYDROGENASE-RXN
xref: Reactome:REACT_25041 "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate, Homo sapiens"
xref: Reactome:REACT_25102 "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde, Homo sapiens"
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0047989
name: hydroxybutyrate-dimer hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-3-[(R)-3-hydroxybutanoyloxy]butanoate + H(2)O = 2 (R)-3-hydroxybutanoate + H(+)." [EC:3.1.1.22, RHEA:10175]
subset: gosubset_prok
synonym: "(R)-3-((R)-3-hydroxybutanoyloxy)butanoate hydroxybutanoylhydrolase activity" EXACT [EC:3.1.1.22]
synonym: "D-(-)-3-hydroxybutyrate-dimer hydrolase activity" EXACT [EC:3.1.1.22]
xref: EC:3.1.1.22
xref: KEGG:R00048
xref: MetaCyc:HYDROXYBUTYRATE-DIMER-HYDROLASE-RXN
xref: RHEA:10175
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0047990
name: hydroxyglutamate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxy-L-glutamate + H(+) = 4-amino-3-hydroxybutanoate + CO(2)." [EC:4.1.1.16, RHEA:14076]
synonym: "3-hydroxy-L-glutamate 1-carboxy-lyase (4-amino-3-hydroxybutanoate-forming)" EXACT [EC:4.1.1.16]
synonym: "3-hydroxy-L-glutamate 1-carboxy-lyase activity" EXACT [EC:4.1.1.16]
xref: EC:4.1.1.16
xref: KEGG:R04135
xref: MetaCyc:HYDROXYGLUTAMATE-DECARBOXYLASE-RXN
xref: RHEA:14076
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047991
name: hydroxylamine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydroxylamine + O(2) = H(2)O + H(+) + nitrite." [EC:1.7.3.4, RHEA:19972]
subset: gosubset_prok
synonym: "HAO" RELATED [EC:1.7.3.4]
synonym: "hydroxylamine oxidoreductase" BROAD [EC:1.7.3.4]
synonym: "hydroxylamine:oxygen oxidoreductase activity" EXACT [EC:1.7.3.4]
xref: EC:1.7.3.4
xref: KEGG:R00793
xref: MetaCyc:HAONITRO-RXN
xref: RHEA:19972
is_a: GO:0016663 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor

[Term]
id: GO:0047992
name: hydroxylysine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: erythro-5-hydroxy-L-lysine + GTP = 5-phosphonooxy-L-lysine + GDP + 2 H(+)." [EC:2.7.1.81, RHEA:19052]
synonym: "GTP:5-hydroxy-L-lysine O-phosphotransferase activity" EXACT [EC:2.7.1.81]
synonym: "guanosine triphosphate:5-hydroxy-L-lysine O-phosphotransferase activity" EXACT [EC:2.7.1.81]
synonym: "hydroxylysine kinase (phosphorylating)" EXACT [EC:2.7.1.81]
xref: EC:2.7.1.81
xref: KEGG:R03378
xref: MetaCyc:HYDROXYLYSINE-KINASE-RXN
xref: RHEA:19052
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047993
name: hydroxymalonate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydroxymalonate + NAD(+) = H(+) + NADH + oxomalonate." [EC:1.1.1.167, RHEA:11287]
synonym: "hydroxymalonate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.167]
xref: EC:1.1.1.167
xref: KEGG:R02969
xref: MetaCyc:HYDROXYMALONATE-DEHYDROGENASE-RXN
xref: RHEA:11287
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047994
name: hydroxymethylglutaryl-CoA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA + H(2)O = 3-hydroxy-3-methylglutarate + CoA + H(+)." [EC:3.1.2.5, RHEA:16308]
synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA hydrolase activity" EXACT [EC:3.1.2.5]
synonym: "3-hydroxy-3-methylglutaryl-CoA hydrolase activity" EXACT [EC:3.1.2.5]
synonym: "beta-hydroxy-beta-methylglutaryl coenzyme A deacylase activity" EXACT [EC:3.1.2.5]
synonym: "beta-hydroxy-beta-methylglutaryl coenzyme A hydrolase activity" EXACT [EC:3.1.2.5]
synonym: "hydroxymethylglutaryl coenzyme A deacylase activity" EXACT [EC:3.1.2.5]
synonym: "hydroxymethylglutaryl coenzyme A hydrolase activity" EXACT [EC:3.1.2.5]
xref: EC:3.1.2.5
xref: KEGG:R02083
xref: MetaCyc:HYDROXYMETHYLGLUTARYL-COA-HYDROLASE-RXN
xref: RHEA:16308
is_a: GO:0016289 ! CoA hydrolase activity

[Term]
id: GO:0047995
name: hydroxyphenylpyruvate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-(4-hydroxyphenyl)lactate + NAD+ = 3-(4-hydroxyphenyl)pyruvate + NADH." [EC:1.1.1.237, MetaCyc:HYDROXYPHENYLPYRUVATE-REDUCTASE-RXN]
synonym: "4-hydroxyphenyllactate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.237]
synonym: "HPRP" RELATED [EC:1.1.1.237]
xref: EC:1.1.1.237
xref: MetaCyc:HYDROXYPHENYLPYRUVATE-REDUCTASE-RXN
xref: RHEA:23367
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047996
name: hydroxyphytanate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2S)-2-hydroxyphytanate + O(2) = 2-oxophytanate + H(2)O(2)." [EC:1.1.3.27, RHEA:21683]
synonym: "L-2-hydroxyphytanate:oxygen 2-oxidoreductase" BROAD [EC:1.1.3.27]
xref: EC:1.1.3.27
xref: KEGG:R07151
xref: MetaCyc:HYDROXYPHYTANATE-OXIDASE-RXN
xref: RHEA:21683
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0047997
name: hydroxypyruvate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxypyruvate + H(+) = CO(2) + glycolaldehyde." [EC:4.1.1.40, RHEA:20564]
synonym: "hydroxypyruvate carboxy-lyase (glycolaldehyde-forming)" EXACT [EC:4.1.1.40]
synonym: "hydroxypyruvate carboxy-lyase activity" EXACT [EC:4.1.1.40]
xref: EC:4.1.1.40
xref: KEGG:R01393
xref: MetaCyc:HYDROXYPYRUVATE-DECARBOXYLASE-RXN
xref: RHEA:20564
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047998
name: hyoscyamine (6S)-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + L-hyoscyamine + O(2) = (6S)-6-hydroxyhyoscyamine + CO(2) + succinate." [EC:1.14.11.11, RHEA:12632]
synonym: "hyoscyamine (6S)-hydroxylase activity" EXACT [EC:1.14.11.11]
synonym: "hyoscyamine 6-beta-hydroxylase activity" EXACT [EC:1.14.11.11]
synonym: "hyoscyamine 6-hydroxylase activity" EXACT [EC:1.14.11.11]
synonym: "hyoscyamine 6beta-dioxygenase activity" EXACT [EC:1.14.11.11]
synonym: "hyoscyamine 6beta-hydroxylase activity" EXACT [EC:1.14.11.11]
synonym: "L-hyoscyamine,2-oxoglutarate:oxygen oxidoreductase ((6S)-hydroxylating)" EXACT [EC:1.14.11.11]
xref: EC:1.14.11.11
xref: KEGG:R03812
xref: MetaCyc:HYOSCYAMINE-6-DIOXYGENASE-RXN
xref: RHEA:12632
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0047999
name: hyponitrite reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 hydroxylamine + 2 NAD(+) = 2 H(+) + hyponitrous acid + 2 NADH." [EC:1.7.1.5, RHEA:19340]
synonym: "hydroxylamine:NAD+ oxidoreductase activity" EXACT [EC:1.7.1.5]
synonym: "NADH2:hyponitrite oxidoreductase activity" EXACT [EC:1.7.1.5]
synonym: "NADH:hyponitrite oxidoreductase activity" EXACT [EC:1.7.1.5]
xref: EC:1.7.1.5
xref: KEGG:R00023
xref: MetaCyc:HYPONITRITE-REDUCTASE-RXN
xref: RHEA:19340
is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor

[Term]
id: GO:0048000
name: isoflavone 3'-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: formononetin + NADPH + O2 = calycosin + NADP+ + H2O." [EC:1.14.13.52, MetaCyc:ISOFLAVONE-3'-HYDROXYLASE-RXN]
synonym: "formononetin,NADPH:oxygen oxidoreductase (3'-hydroxylating)" EXACT [EC:1.14.13.52]
synonym: "isoflavone 3'-monooxygenase activity" EXACT [EC:1.14.13.52]
xref: EC:1.14.13.52
xref: MetaCyc:RXN-3762
xref: RHEA:22963
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0048001
name: erythrose-4-phosphate dehydrogenase activity
namespace: molecular_function
alt_id: GO:0033724
def: "Catalysis of the reaction: D-erythrose 4-phosphate + H(2)O + NAD(+) = 4-phospho-D-erythronate + 2 H(+) + NADH." [EC:1.2.1.72, RHEA:12059]
synonym: "D-erythrose 4-phosphate:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.72]
synonym: "E4P dehydrogenase activity" EXACT [EC:1.2.1.72]
synonym: "E4PDH" EXACT [EC:1.2.1.72]
synonym: "Epd dehydrogenase activity" EXACT [EC:1.2.1.72]
synonym: "erythrose 4-phosphate dehydrogenase activity" EXACT [EC:1.2.1.72]
synonym: "GapB" RELATED [EC:1.2.1.72]
xref: EC:1.2.1.72
xref: KEGG:R01825
xref: MetaCyc:ERYTH4PDEHYDROG-RXN
xref: RHEA:12059
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0048002
name: antigen processing and presentation of peptide antigen
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses peptide antigen in association with an MHC protein complex on its cell surface, including proteolysis and transport steps for the peptide antigen both prior to and following assembly with the MHC protein complex. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein." [GOC:add, ISBN:0781735149, PMID:15771591]
synonym: "antigen presentation, peptide antigen" EXACT []
synonym: "peptide antigen processing and presentation" EXACT []
is_a: GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0048003
name: antigen processing and presentation of lipid antigen via MHC class Ib
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses lipid antigen in association with an MHC class Ib protein complex on its cell surface, including lipid extraction, degradation, and transport steps for the lipid antigen both prior to and following assembly with the MHC protein complex. The lipid antigen may originate from an endogenous or exogenous source of lipid. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family." [GOC:add, PMID:10375559, PMID:15928678, PMID:15928680]
synonym: "antigen presentation, lipid antigen" EXACT []
synonym: "lipid antigen processing and presentation via MHC class Ib" EXACT []
is_a: GO:0002475 ! antigen processing and presentation via MHC class Ib

[Term]
id: GO:0048006
name: antigen processing and presentation, endogenous lipid antigen via MHC class Ib
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses lipid antigen of endogenous origin in association with an MHC class Ib protein complex on its cell surface. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family." [GOC:add, PMID:10375559, PMID:15928678, PMID:15928680]
synonym: "antigen presentation, endogenous lipid antigen" EXACT []
synonym: "endogenous lipid antigen processing and presentation via MHC class Ib" EXACT []
is_a: GO:0019883 ! antigen processing and presentation of endogenous antigen
is_a: GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib

[Term]
id: GO:0048007
name: antigen processing and presentation, exogenous lipid antigen via MHC class Ib
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses lipid antigen of exogenous origin in association with an MHC class Ib protein complex on its cell surface. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family." [GOC:add, PMID:10375559, PMID:15928678, PMID:15928680]
synonym: "antigen presentation, exogenous peptide antigen" EXACT []
synonym: "exogenous lipid antigen processing and presentation via MHC class Ib" EXACT []
is_a: GO:0019884 ! antigen processing and presentation of exogenous antigen
is_a: GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib

[Term]
id: GO:0048008
name: platelet-derived growth factor receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor binding to one of its physiological ligands." [GOC:ceb]
synonym: "PDGF receptor signaling pathway" EXACT []
synonym: "PDGF receptor signalling pathway" EXACT []
synonym: "PDGFR signaling pathway" EXACT []
is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway

[Term]
id: GO:0048009
name: insulin-like growth factor receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of the insulin-like growth factor receptor binding to one of its physiological ligands." [GOC:ceb]
synonym: "IGF receptor signaling pathway" EXACT []
synonym: "IGF receptor signalling pathway" EXACT []
is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway

[Term]
id: GO:0048010
name: vascular endothelial growth factor receptor signaling pathway
namespace: biological_process
def: "Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling, PR:000001971]
comment: In GO, a gene product with 'vascular endothelial growth factor-activated receptor activity ; GO:0005021' necessarily binds VEGF to transduce a signal. In contrast, the VEGFR refers to PR:000001971. To represent cross-talk between ligands and receptors, signaling pathways in GO are starting to be named after the receptor and/or the signal. GO:0048010 is for annotation of any pathway in which a ligand (VEGF or an alternative growth factor) binds and activates a VEGFR (PR:000001971). For annotation of signaling pathways where a VEGF binds to a cell surface receptor (VEGFR, PDGFR etc.), consider 'vascular endothelial growth factor signaling pathway ; GO:0038084'.
synonym: "VEGF receptor signaling pathway" EXACT []
synonym: "VEGF receptor signalling pathway" EXACT []
synonym: "VEGFR signaling pathway" EXACT []
xref: Reactome:REACT_100751 "Signaling by VEGF, Xenopus tropicalis"
xref: Reactome:REACT_102305 "Signaling by VEGF, Gallus gallus"
xref: Reactome:REACT_105684 "Signaling by VEGF, Taeniopygia guttata"
xref: Reactome:REACT_106374 "Signaling by VEGF, Sus scrofa"
xref: Reactome:REACT_108554 "VEGF ligand-receptor interactions, Mus musculus"
xref: Reactome:REACT_110014 "Signaling by VEGF, Canis familiaris"
xref: Reactome:REACT_12380 "VEGF ligand-receptor interactions, Homo sapiens"
xref: Reactome:REACT_12529 "Signaling by VEGF, Homo sapiens"
xref: Reactome:REACT_28600 "VEGF ligand-receptor interactions, Rattus norvegicus"
xref: Reactome:REACT_29612 "VEGF ligand-receptor interactions, Danio rerio"
xref: Reactome:REACT_79122 "VEGF ligand-receptor interactions, Bos taurus"
xref: Reactome:REACT_82633 "VEGF ligand-receptor interactions, Taeniopygia guttata"
xref: Reactome:REACT_82784 "Signaling by VEGF, Danio rerio"
xref: Reactome:REACT_82920 "Signaling by VEGF, Bos taurus"
xref: Reactome:REACT_85693 "Signaling by VEGF, Rattus norvegicus"
xref: Reactome:REACT_86899 "VEGF ligand-receptor interactions, Sus scrofa"
xref: Reactome:REACT_90528 "Signaling by VEGF, Mus musculus"
xref: Reactome:REACT_94269 "VEGF ligand-receptor interactions, Canis familiaris"
xref: Reactome:REACT_98511 "VEGF ligand-receptor interactions, Gallus gallus"
xref: Reactome:REACT_99958 "VEGF ligand-receptor interactions, Xenopus tropicalis"
is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway

[Term]
id: GO:0048011
name: neurotrophin TRK receptor signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of a neurotrophin to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:ceb, GOC:jc, GOC:signaling, PMID:12065629, Wikipedia:Trk_receptor]
synonym: "TrkA signaling pathway" NARROW [Wikipedia:TrkA]
synonym: "TrkB signaling pathway" NARROW [Wikipedia:TrkB]
synonym: "TrkC signaling pathway" NARROW [Wikipedia:TrkC]
synonym: "tropomyosin-receptor-kinase signaling" EXACT [Wikipedia:Trk_receptor]
xref: Reactome:REACT_100491 "TRKA activation by NGF, Xenopus tropicalis"
xref: Reactome:REACT_102185 "TRKA activation by NGF, Rattus norvegicus"
xref: Reactome:REACT_102596 "TRKA activation by NGF, Sus scrofa"
xref: Reactome:REACT_103421 "Signalling by NGF, Danio rerio"
xref: Reactome:REACT_104456 "p75 NTR receptor-mediated signalling, Bos taurus"
xref: Reactome:REACT_105007 "NFG and proNGF binds to p75NTR, Xenopus tropicalis"
xref: Reactome:REACT_105350 "TRKA activation by NGF, Gallus gallus"
xref: Reactome:REACT_105497 "Signalling by NGF, Taeniopygia guttata"
xref: Reactome:REACT_105533 "p75 NTR receptor-mediated signalling, Xenopus tropicalis"
xref: Reactome:REACT_106137 "NFG and proNGF binds to p75NTR, Canis familiaris"
xref: Reactome:REACT_106661 "TRKA activation by NGF, Canis familiaris"
xref: Reactome:REACT_110112 "NFG and proNGF binds to p75NTR, Rattus norvegicus"
xref: Reactome:REACT_110454 "p75 NTR receptor-mediated signalling, Taeniopygia guttata"
xref: Reactome:REACT_11060 "TRKA activation by NGF, Homo sapiens"
xref: Reactome:REACT_11061 "Signalling by NGF, Homo sapiens"
xref: Reactome:REACT_112151 "Signalling by NGF, Plasmodium falciparum"
xref: Reactome:REACT_112852 "p75 NTR receptor-mediated signalling, Dictyostelium discoideum"
xref: Reactome:REACT_13724 "NFG and proNGF binds to p75NTR, Homo sapiens"
xref: Reactome:REACT_13776 "p75 NTR receptor-mediated signalling, Homo sapiens"
xref: Reactome:REACT_30900 "Signalling by NGF, Mycobacterium tuberculosis"
xref: Reactome:REACT_31356 "p75 NTR receptor-mediated signalling, Gallus gallus"
xref: Reactome:REACT_31983 "Signalling by NGF, Dictyostelium discoideum"
xref: Reactome:REACT_32667 "NFG and proNGF binds to p75NTR, Danio rerio"
xref: Reactome:REACT_32837 "NFG and proNGF binds to p75NTR, Bos taurus"
xref: Reactome:REACT_33617 "Signalling by NGF, Sus scrofa"
xref: Reactome:REACT_76926 "NFG and proNGF binds to p75NTR, Sus scrofa"
xref: Reactome:REACT_77946 "p75 NTR receptor-mediated signalling, Oryza sativa"
xref: Reactome:REACT_78398 "p75 NTR receptor-mediated signalling, Rattus norvegicus"
xref: Reactome:REACT_78786 "TRKA activation by NGF, Danio rerio"
xref: Reactome:REACT_80900 "p75 NTR receptor-mediated signalling, Schizosaccharomyces pombe"
xref: Reactome:REACT_81498 "NFG and proNGF binds to p75NTR, Gallus gallus"
xref: Reactome:REACT_82003 "p75 NTR receptor-mediated signalling, Arabidopsis thaliana"
xref: Reactome:REACT_82110 "Signalling by NGF, Caenorhabditis elegans"
xref: Reactome:REACT_82686 "Signalling by NGF, Arabidopsis thaliana"
xref: Reactome:REACT_83545 "p75 NTR receptor-mediated signalling, Caenorhabditis elegans"
xref: Reactome:REACT_83987 "NFG and proNGF binds to p75NTR, Mus musculus"
xref: Reactome:REACT_84223 "TRKA activation by NGF, Mus musculus"
xref: Reactome:REACT_85941 "Signalling by NGF, Canis familiaris"
xref: Reactome:REACT_86675 "Signalling by NGF, Mus musculus"
xref: Reactome:REACT_90112 "Signalling by NGF, Oryza sativa"
xref: Reactome:REACT_90509 "TRKA activation by NGF, Bos taurus"
xref: Reactome:REACT_90598 "Signalling by NGF, Saccharomyces cerevisiae"
xref: Reactome:REACT_93200 "p75 NTR receptor-mediated signalling, Drosophila melanogaster"
xref: Reactome:REACT_93733 "Signalling by NGF, Bos taurus"
xref: Reactome:REACT_94799 "p75 NTR receptor-mediated signalling, Mus musculus"
xref: Reactome:REACT_96194 "Signalling by NGF, Rattus norvegicus"
xref: Reactome:REACT_97378 "Signalling by NGF, Drosophila melanogaster"
xref: Reactome:REACT_98121 "p75 NTR receptor-mediated signalling, Saccharomyces cerevisiae"
xref: Reactome:REACT_98186 "Signalling by NGF, Schizosaccharomyces pombe"
xref: Reactome:REACT_98567 "p75 NTR receptor-mediated signalling, Canis familiaris"
xref: Reactome:REACT_98933 "Signalling by NGF, Xenopus tropicalis"
xref: Reactome:REACT_99175 "p75 NTR receptor-mediated signalling, Sus scrofa"
xref: Reactome:REACT_99519 "Signalling by NGF, Gallus gallus"
xref: Reactome:REACT_99699 "p75 NTR receptor-mediated signalling, Danio rerio"
is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway
is_a: GO:0038179 ! neurotrophin signaling pathway

[Term]
id: GO:0048012
name: hepatocyte growth factor receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of the hepatocyte growth factor receptor binding to one of its physiological ligands." [GOC:ceb]
synonym: "HGF receptor signaling pathway" EXACT []
synonym: "HGF receptor signalling pathway" EXACT []
synonym: "Met signaling pathway" NARROW []
is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway

[Term]
id: GO:0048013
name: ephrin receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin." [GOC:ceb]
synonym: "Eph receptor signaling pathway" EXACT []
synonym: "Eph receptor signalling pathway" EXACT []
is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway

[Term]
id: GO:0048014
name: Tie signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a Tie protein (a receptor) binding to one of its physiological ligands (an angiopoietin)." [GOC:ceb, GOC:signaling, PMID:11283723, PMID:11566266]
synonym: "angiopoietin-Tie signaling pathway" NARROW [PMID:22951441]
synonym: "angiopoietin/Tie signaling pathway" NARROW [PMID:11566266]
synonym: "Tek receptor signaling" EXACT []
synonym: "Tie receptor signaling pathway" EXACT [GOC:ceb]
synonym: "Tie receptor signalling pathway" EXACT []
is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway

[Term]
id: GO:0048015
name: phosphatidylinositol-mediated signaling
namespace: biological_process
def: "A series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, GOC:ceb, ISBN:0198506732]
subset: gosubset_prok
synonym: "inositol phospholipid-mediated signaling" BROAD []
synonym: "phosphatidylinositol-mediated signal transduction" EXACT [GOC:signaling]
synonym: "phosphatidylinositol-mediated signalling" EXACT [GOC:curators]
synonym: "phosphoinositide-mediated signaling" EXACT [GOC:curators]
synonym: "phosphoinositide-mediated signalling" EXACT []
xref: Reactome:REACT_100700 "PI3K/AKT activation, Drosophila melanogaster"
xref: Reactome:REACT_100744 "PI3K/AKT activation, Canis familiaris"
xref: Reactome:REACT_102918 "PI3K/AKT activation, Dictyostelium discoideum"
xref: Reactome:REACT_103414 "PI3K/AKT activation, Schizosaccharomyces pombe"
xref: Reactome:REACT_12464 "PI3K/AKT activation, Homo sapiens"
xref: Reactome:REACT_30485 "PI3K/AKT activation, Sus scrofa"
xref: Reactome:REACT_30540 "PI3K/AKT activation, Bos taurus"
xref: Reactome:REACT_31601 "PI3K/AKT activation, Rattus norvegicus"
xref: Reactome:REACT_34273 "PI3K/AKT activation, Danio rerio"
xref: Reactome:REACT_80094 "PI3K/AKT activation, Xenopus tropicalis"
xref: Reactome:REACT_82991 "PI3K/AKT activation, Gallus gallus"
xref: Reactome:REACT_83574 "PI3K/AKT activation, Saccharomyces cerevisiae"
xref: Reactome:REACT_88072 "PI3K/AKT activation, Oryza sativa"
xref: Reactome:REACT_90315 "PI3K/AKT activation, Mus musculus"
xref: Reactome:REACT_96510 "PI3K/AKT activation, Taeniopygia guttata"
xref: Reactome:REACT_97318 "PI3K/AKT activation, Arabidopsis thaliana"
xref: Reactome:REACT_97931 "PI3K/AKT activation, Caenorhabditis elegans"
is_a: GO:0048017 ! inositol lipid-mediated signaling

[Term]
id: GO:0048016
name: inositol phosphate-mediated signaling
namespace: biological_process
def: "Any intracellular signal transduction in which the signal is passed on within the cell via an inositol phosphate. Includes production of the inositol phosphate, and downstream effectors that further transmit the signal within the cell. Inositol phosphates are a group of mono- to poly-phosphorylated inositols, and include inositol monophosphate (IP), inositol trisphosphate (IP3), inositol pentakisphosphate (IP5) and inositol hexaphosphate (IP6)." [GOC:bf, GOC:ceb, GOC:signaling, ISBN:0198506732, PMID:11331907]
synonym: "inositol phosphate-mediated signalling" EXACT []
is_a: GO:0019932 ! second-messenger-mediated signaling

[Term]
id: GO:0048017
name: inositol lipid-mediated signaling
namespace: biological_process
def: "A series of molecular signals in which a cell uses an inositol-containing lipid to convert a signal into a response. Inositol lipids include the phosphoinositides (phosphatidylinositol and its phosphorylated derivatives), ceramides containing inositol, and inositol glycolipids." [GOC:bf, GOC:ceb, PMID:16088939]
synonym: "inositol lipid-mediated signal transduction" EXACT [GOC:signaling]
synonym: "inositol lipid-mediated signalling" EXACT []
synonym: "inositol phospholipid-mediated signaling" NARROW []
is_a: GO:0035556 ! intracellular signal transduction

[Term]
id: GO:0048018
name: receptor agonist activity
namespace: molecular_function
def: "Interacts with receptors such that the proportion of receptors in the active form is increased." [GOC:ceb, ISBN:0198506732]
subset: goslim_chembl
synonym: "receptor ligand activity" BROAD [GOC:mtg_signaling]
is_a: GO:0004871 ! signal transducer activity
is_a: GO:0005102 ! receptor binding
is_a: GO:0030546 ! receptor activator activity
relationship: part_of GO:0007165 ! signal transduction

[Term]
id: GO:0048019
name: receptor antagonist activity
namespace: molecular_function
def: "Interacts with receptors to reduce the action of another ligand, the agonist." [GOC:ceb, ISBN:0198506732]
synonym: "receptor ligand activity" BROAD [GOC:mtg_signaling]
is_a: GO:0005102 ! receptor binding
is_a: GO:0030547 ! receptor inhibitor activity
relationship: part_of GO:1900116 ! extracellular negative regulation of signal transduction

[Term]
id: GO:0048020
name: CCR chemokine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a CCR chemokine receptor." [GOC:ai]
synonym: "beta chemokine receptor binding" EXACT []
synonym: "beta chemokine receptor ligand" NARROW []
synonym: "CCR chemokine receptor ligand" NARROW []
is_a: GO:0042379 ! chemokine receptor binding

[Term]
id: GO:0048021
name: regulation of melanin biosynthetic process
namespace: biological_process
def: "Any process that alters the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of melanin." [GOC:jid]
subset: gosubset_prok
synonym: "regulation of melanin anabolism" EXACT []
synonym: "regulation of melanin biosynthesis" EXACT []
synonym: "regulation of melanin formation" EXACT []
synonym: "regulation of melanin synthesis" EXACT []
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042438 ! melanin biosynthetic process
relationship: regulates GO:0042438 ! melanin biosynthetic process

[Term]
id: GO:0048022
name: negative regulation of melanin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of melanin." [GOC:jid]
subset: gosubset_prok
synonym: "down regulation of melanin biosynthetic process" EXACT []
synonym: "down-regulation of melanin biosynthetic process" EXACT []
synonym: "downregulation of melanin biosynthetic process" EXACT []
synonym: "inhibition of melanin biosynthetic process" NARROW []
synonym: "negative regulation of melanin anabolism" EXACT []
synonym: "negative regulation of melanin biosynthesis" EXACT []
synonym: "negative regulation of melanin formation" EXACT []
synonym: "negative regulation of melanin synthesis" EXACT []
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0048021 ! regulation of melanin biosynthetic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042438 ! melanin biosynthetic process
relationship: negatively_regulates GO:0042438 ! melanin biosynthetic process

[Term]
id: GO:0048023
name: positive regulation of melanin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the rate or extent of the chemical reactions and pathways resulting in the formation of melanin." [GOC:jid]
subset: gosubset_prok
synonym: "activation of melanin biosynthetic process" NARROW []
synonym: "positive regulation of melanin anabolism" EXACT []
synonym: "positive regulation of melanin biosynthesis" EXACT []
synonym: "positive regulation of melanin formation" EXACT []
synonym: "positive regulation of melanin synthesis" EXACT []
synonym: "stimulation of melanin biosynthetic process" NARROW []
synonym: "up regulation of melanin biosynthetic process" EXACT []
synonym: "up-regulation of melanin biosynthetic process" EXACT []
synonym: "upregulation of melanin biosynthetic process" EXACT []
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0048021 ! regulation of melanin biosynthetic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042438 ! melanin biosynthetic process
relationship: positively_regulates GO:0042438 ! melanin biosynthetic process

[Term]
id: GO:0048024
name: regulation of mRNA splicing, via spliceosome
namespace: biological_process
alt_id: GO:0035055
def: "Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid]
synonym: "regulation of nuclear mRNA splicing via U2-type spliceosome" NARROW []
synonym: "regulation of nuclear mRNA splicing, via spliceosome" EXACT [GOC:vw]
synonym: "regulation of pre-mRNA splicing" BROAD []
is_a: GO:0043484 ! regulation of RNA splicing
is_a: GO:0050684 ! regulation of mRNA processing
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000398 ! mRNA splicing, via spliceosome
relationship: regulates GO:0000398 ! mRNA splicing, via spliceosome

[Term]
id: GO:0048025
name: negative regulation of mRNA splicing, via spliceosome
namespace: biological_process
alt_id: GO:0035056
def: "Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid]
synonym: "down regulation of nuclear mRNA splicing via U2-type spliceosome" NARROW []
synonym: "down regulation of nuclear mRNA splicing, via spliceosome" EXACT []
synonym: "down-regulation of nuclear mRNA splicing via U2-type spliceosome" NARROW []
synonym: "down-regulation of nuclear mRNA splicing, via spliceosome" EXACT []
synonym: "downregulation of nuclear mRNA splicing via U2-type spliceosome" NARROW []
synonym: "downregulation of nuclear mRNA splicing, via spliceosome" EXACT []
synonym: "inhibition of nuclear mRNA splicing via U2-type spliceosome" NARROW []
synonym: "inhibition of nuclear mRNA splicing, via spliceosome" NARROW []
synonym: "negative regulation of nuclear mRNA splicing via U2-type spliceosome" NARROW []
synonym: "negative regulation of nuclear mRNA splicing, via spliceosome" EXACT [GOC:vw]
synonym: "negative regulation of pre-mRNA splicing" BROAD []
is_a: GO:0033119 ! negative regulation of RNA splicing
is_a: GO:0048024 ! regulation of mRNA splicing, via spliceosome
is_a: GO:0050686 ! negative regulation of mRNA processing
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000398 ! mRNA splicing, via spliceosome
relationship: negatively_regulates GO:0000398 ! mRNA splicing, via spliceosome

[Term]
id: GO:0048026
name: positive regulation of mRNA splicing, via spliceosome
namespace: biological_process
alt_id: GO:0035057
def: "Any process that activates or increases the rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid]
synonym: "activation of nuclear mRNA splicing via U2-type spliceosome" NARROW []
synonym: "activation of nuclear mRNA splicing, via spliceosome" NARROW []
synonym: "positive regulation of nuclear mRNA splicing via U2-type spliceosome" NARROW []
synonym: "positive regulation of nuclear mRNA splicing, via spliceosome" EXACT [GOC:vw]
synonym: "positive regulation of pre-mRNA splicing" BROAD []
synonym: "stimulation of nuclear mRNA splicing via U2-type spliceosome" NARROW []
synonym: "stimulation of nuclear mRNA splicing, via spliceosome" NARROW []
synonym: "up regulation of nuclear mRNA splicing via U2-type spliceosome" NARROW []
synonym: "up regulation of nuclear mRNA splicing, via spliceosome" EXACT []
synonym: "up-regulation of nuclear mRNA splicing via U2-type spliceosome" NARROW []
synonym: "up-regulation of nuclear mRNA splicing, via spliceosome" EXACT []
synonym: "upregulation of nuclear mRNA splicing via U2-type spliceosome" NARROW []
synonym: "upregulation of nuclear mRNA splicing, via spliceosome" EXACT []
is_a: GO:0033120 ! positive regulation of RNA splicing
is_a: GO:0048024 ! regulation of mRNA splicing, via spliceosome
is_a: GO:0050685 ! positive regulation of mRNA processing
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000398 ! mRNA splicing, via spliceosome
relationship: positively_regulates GO:0000398 ! mRNA splicing, via spliceosome

[Term]
id: GO:0048027
name: mRNA 5'-UTR binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the 5' untranslated region of an mRNA molecule." [GOC:jid]
subset: gosubset_prok
synonym: "mRNA 5' UTR binding" EXACT []
is_a: GO:0003729 ! mRNA binding

[Term]
id: GO:0048028
name: galacturonan binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any simple or complex galacturonan. Galacturonan is any glycan composed solely of galacturonic acid residues, a specific type of glycuronan, and a constituent of some pectins." [GOC:jid]
subset: gosubset_prok
synonym: "polygalacturonide binding" RELATED []
is_a: GO:0030247 ! polysaccharide binding

[Term]
id: GO:0048029
name: monosaccharide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [CHEBI:35381, GOC:jid]
subset: gosubset_prok
is_a: GO:0030246 ! carbohydrate binding
is_a: GO:0036094 ! small molecule binding

[Term]
id: GO:0048030
name: disaccharide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any disaccharide. Disaccharides are sugars composed of two monosaccharide units." [GOC:jid]
is_a: GO:0070492 ! oligosaccharide binding

[Term]
id: GO:0048031
name: trisaccharide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any trisaccharide. Trisaccharides are sugars composed of three monosaccharide units." [GOC:jid]
is_a: GO:0070492 ! oligosaccharide binding

[Term]
id: GO:0048032
name: galacturonate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any galacturonate. Galacturonate is the anion of galacturonic acid, the uronic acid formally derived from galactose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group." [CHEBI:33812, GOC:jid]
synonym: "galacturonic acid binding" EXACT []
is_a: GO:0033293 ! monocarboxylic acid binding
is_a: GO:0048029 ! monosaccharide binding

[Term]
id: GO:0048033
name: heme o metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving heme O, a derivative of heme containing a 17-carbon hydroxyethylfarnesyl side chain at position 8 of the tetrapyrrole macrocycle." [GOC:jid]
subset: gosubset_prok
synonym: "haem o metabolic process" EXACT []
synonym: "haem o metabolism" EXACT []
synonym: "heme o metabolism" EXACT []
is_a: GO:0042168 ! heme metabolic process

[Term]
id: GO:0048034
name: heme O biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of heme O, a derivative of heme containing a 17-carbon hydroxyethylfarnesyl side chain at position 8 of the tetrapyrrole macrocycle." [GOC:jid]
subset: gosubset_prok
synonym: "haem O biosynthesis" EXACT []
synonym: "haem O biosynthetic process" EXACT []
synonym: "heme O anabolism" EXACT []
synonym: "heme O biosynthesis" EXACT []
synonym: "heme O formation" EXACT []
synonym: "heme O synthesis" EXACT []
is_a: GO:0006783 ! heme biosynthetic process
is_a: GO:0048033 ! heme o metabolic process

[Term]
id: GO:0048035
name: heme o catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of heme O, a derivative of heme containing a 17-carbon hydroxyethylfarnesyl side chain at position 8 of the tetrapyrrole macrocycle." [GOC:jid]
subset: gosubset_prok
synonym: "haem o catabolic process" EXACT []
synonym: "haem o catabolism" EXACT []
synonym: "heme o breakdown" EXACT []
synonym: "heme o catabolism" EXACT []
synonym: "heme o degradation" EXACT []
is_a: GO:0042167 ! heme catabolic process
is_a: GO:0048033 ! heme o metabolic process

[Term]
id: GO:0048036
name: central complex development
namespace: biological_process
def: "The process whose specific outcome is the progression of the central complex over time, from its formation to the mature structure. The central complex region of the insect brain is thought to be crucial for control of locomotive behavior. Located in the middle of the two protocerebral hemispheres, it comprises four neuropilar regions, the fan-shaped body, the ellipsoid body, the protocerebral bridge and the paired noduli." [PMID:12490252]
synonym: "central body development" EXACT []
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007420 ! brain development

[Term]
id: GO:0048037
name: cofactor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate." [ISBN:0198506732]
subset: goslim_metagenomics
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0048038
name: quinone binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds." [ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0048037 ! cofactor binding

[Term]
id: GO:0048039
name: ubiquinone binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with ubiquinone, a quinone derivative with a tail of isoprene units." [GOC:jid, ISBN:0582227089]
subset: gosubset_prok
synonym: "coenzyme Q binding" EXACT []
synonym: "coenzyme Q6 binding" NARROW []
is_a: GO:0048038 ! quinone binding

[Term]
id: GO:0048040
name: UDP-glucuronate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(+) + UDP-alpha-D-glucuronate = CO(2) + UDP-alpha-D-xylose." [EC:4.1.1.35, RHEA:23919]
synonym: "UDP-D-glucuronate carboxy-lyase (UDP-D-xylose-forming)" EXACT [EC:4.1.1.35]
synonym: "UDP-D-glucuronate carboxy-lyase activity" EXACT [EC:4.1.1.35]
synonym: "UDP-glucuronic acid decarboxylase activity" EXACT []
synonym: "UDPglucuronate decarboxylase activity" EXACT [EC:4.1.1.35]
synonym: "uridine-diphosphoglucuronate decarboxylase activity" EXACT [EC:4.1.1.35]
xref: EC:4.1.1.35
xref: KEGG:R01384
xref: MetaCyc:UDP-GLUCURONATE-DECARBOXYLASE-RXN
xref: RHEA:23919
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0048041
name: focal adhesion assembly
namespace: biological_process
def: "The aggregation and bonding together of a set of components to form a focal adhesion, a complex of intracellular signaling and structural proteins that provides a structural link between the internal actin cytoskeleton and the ECM, and also function as a locus of signal transduction activity." [GOC:jid, GOC:mah]
synonym: "adhesion plaque assembly" RELATED []
synonym: "focal adhesion formation" RELATED [GOC:mah]
is_a: GO:0007045 ! cell-substrate adherens junction assembly
relationship: part_of GO:0007160 ! cell-matrix adhesion

[Term]
id: GO:0048042
name: regulation of post-mating oviposition
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the deposition of eggs, either fertilized or not, upon a surface or into a medium, following mating." [GOC:dph, GOC:tb, PMID:11932766]
synonym: "regulation of oviposition, post-mating" EXACT [GOC:dph, GOC:tb]
is_a: GO:0046662 ! regulation of oviposition
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060403 ! post-mating oviposition
relationship: regulates GO:0060403 ! post-mating oviposition

[Term]
id: GO:0048045
name: trans-pentaprenyltranstransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: all-trans-pentaprenyl diphosphate + isopentenyl diphosphate = all-trans-hexaprenyl diphosphate + diphosphate." [RHEA:22635]
comment: This term represents a deleted EC activity and is scheduled for obsoletion.
subset: mf_needs_review
synonym: "all-trans-hexaprenyl-diphosphate synthase activity" EXACT [EC:2.5.1.-]
synonym: "all-trans-pentaprenyl-diphosphate:isopentenyl-diphosphate pentaprenyltranstransferase activity" EXACT [EC:2.5.1.-]
synonym: "hexaprenyl diphosphate synthase activity" EXACT [EC:2.5.1.-]
synonym: "hexaprenyl pyrophosphate synthetase activity" EXACT []
xref: EC:2.5.1.-
xref: KEGG:R05613
xref: RHEA:22635
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0048046
name: apoplast
namespace: cellular_component
def: "The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it." [GOC:jid]
xref: Wikipedia:Apoplast
is_a: GO:0005576 ! extracellular region

[Term]
id: GO:0048047
name: mating behavior, sex discrimination
namespace: biological_process
def: "The behavior of individuals for the purpose of discriminating between the sexes, for the purpose of finding a suitable mating partner." [GOC:jid, GOC:pr, PMID:12486700]
synonym: "mating behaviour, sex discrimination" EXACT []
is_a: GO:0007617 ! mating behavior

[Term]
id: GO:0048048
name: embryonic eye morphogenesis
namespace: biological_process
def: "The process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized." [GOC:jid]
is_a: GO:0048562 ! embryonic organ morphogenesis
is_a: GO:0048592 ! eye morphogenesis

[Term]
id: GO:0048050
name: post-embryonic eye morphogenesis
namespace: biological_process
alt_id: GO:0048051
def: "The process, occurring after embryonic development, by which the anatomical structures of the eye are generated and organized. The eye is the organ of sight." [GOC:jid, GOC:sensu]
is_a: GO:0048563 ! post-embryonic organ morphogenesis
is_a: GO:0048592 ! eye morphogenesis

[Term]
id: GO:0048052
name: R1/R6 cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire the specialized features of R1 and R6 photoreceptors. An example of this process is found in Drosophila melanogaster." [GOC:jid]
is_a: GO:0001751 ! compound eye photoreceptor cell differentiation

[Term]
id: GO:0048053
name: R1/R6 development
namespace: biological_process
def: "The process whose specific outcome is the progression of the R1 and R6 pair of photoreceptors in the eye over time, from their formation to the mature structures. R1 and R6 are paired photoreceptors that contribute to the outer rhabdomeres. An example of this process is found in Drosophila melanogaster." [GOC:jid]
is_a: GO:0042051 ! compound eye photoreceptor development
relationship: part_of GO:0048052 ! R1/R6 cell differentiation

[Term]
id: GO:0048054
name: R2/R5 cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire the specialized features of R2 and R5 photoreceptors. An example of this process is found in Drosophila melanogaster." [GOC:jid]
is_a: GO:0001751 ! compound eye photoreceptor cell differentiation

[Term]
id: GO:0048055
name: R2/R5 development
namespace: biological_process
def: "The process whose specific outcome is the progression of the R2 and R5 pair of photoreceptors in the eye over time, from their formation to the mature structures. R2 and R5 are paired photoreceptors that contribute to the outer rhabdomeres. An example of this process is found in Drosophila melanogaster." [GOC:jid]
is_a: GO:0042051 ! compound eye photoreceptor development
relationship: part_of GO:0048054 ! R2/R5 cell differentiation

[Term]
id: GO:0048056
name: R3/R4 cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire the specialized features of R3 and R4 photoreceptors. An example of this process is found in Drosophila melanogaster." [GOC:jid]
is_a: GO:0001751 ! compound eye photoreceptor cell differentiation

[Term]
id: GO:0048057
name: R3/R4 development
namespace: biological_process
def: "The process whose specific outcome is the progression of the R3 and R4 pair of photoreceptors in the eye over time, from their formation to the mature structures. R3 and R4 are paired photoreceptors that contribute to the outer rhabdomeres. An example of this process is found in Drosophila melanogaster." [GOC:jid]
is_a: GO:0042051 ! compound eye photoreceptor development
relationship: part_of GO:0048056 ! R3/R4 cell differentiation

[Term]
id: GO:0048058
name: compound eye corneal lens development
namespace: biological_process
def: "The process whose specific outcome is the progression of the corneal lens in the compound eye over time, from its formation to the mature structure. The corneal lens is a chitinous extracellular secretion of the four underlying cone cells and the pigment cells." [GOC:jid]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048749 ! compound eye development

[Term]
id: GO:0048060
name: negative gravitaxis
namespace: biological_process
alt_id: GO:0048063
def: "The directed movement of a motile cell or organism away from the source of gravity." [GOC:jid]
synonym: "negative geotactic behavior" EXACT []
synonym: "negative geotactic behaviour" EXACT []
synonym: "negative gravitactic behavior" EXACT []
synonym: "negative gravitactic behaviour" EXACT []
synonym: "negative taxis in response to gravity" EXACT []
synonym: "negative taxis in response to gravitytaxis in response to gravitational stimulus" EXACT []
is_a: GO:0042332 ! gravitaxis

[Term]
id: GO:0048061
name: positive gravitaxis
namespace: biological_process
alt_id: GO:0048064
def: "The directed movement of a motile cell or organism towards the source of gravity." [GOC:jid]
synonym: "positive geotactic behavior" EXACT []
synonym: "positive geotactic behaviour" EXACT []
synonym: "positive gravitactic behavior" EXACT []
synonym: "positive gravitactic behaviour" EXACT []
synonym: "positive taxis in response to gravity" EXACT []
synonym: "positive taxis in response to gravitytaxis in response to gravitational stimulus" EXACT []
is_a: GO:0042332 ! gravitaxis

[Term]
id: GO:0048065
name: male courtship behavior, veined wing extension
namespace: biological_process
def: "The process during courtship where the male insect extends his wings. An example of this process is found in Drosophila melanogaster." [GOC:jid, GOC:mtg_sensu]
synonym: "male courtship behavior, wing extension" BROAD []
synonym: "male courtship behaviour, veined wing extension" EXACT []
synonym: "male courtship behaviour, wing extension" BROAD []
is_a: GO:0008049 ! male courtship behavior

[Term]
id: GO:0048066
name: developmental pigmentation
namespace: biological_process
def: "The developmental process that results in the deposition of coloring matter in an organism, tissue or cell." [ISBN:0582227089]
subset: gosubset_prok
synonym: "pigmentation during development" RELATED []
is_a: GO:0043473 ! pigmentation
is_a: GO:0044767 ! single-organism developmental process

[Term]
id: GO:0048067
name: cuticle pigmentation
namespace: biological_process
def: "Establishment of a pattern of pigment in the cuticle of an organism." [GOC:jid]
is_a: GO:0048066 ! developmental pigmentation
relationship: part_of GO:0042335 ! cuticle development

[Term]
id: GO:0048069
name: eye pigmentation
namespace: biological_process
def: "Establishment of a pattern of pigment in the eye of an organism." [GOC:jid]
xref: Wikipedia:Eye_color
is_a: GO:0048066 ! developmental pigmentation

[Term]
id: GO:0048070
name: regulation of developmental pigmentation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism." [GOC:dph, GOC:jid, GOC:tb]
synonym: "regulation of pigmentation during development" EXACT [GOC:dph, GOC:tb]
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048066 ! developmental pigmentation
relationship: regulates GO:0048066 ! developmental pigmentation

[Term]
id: GO:0048071
name: sex-specific pigmentation
namespace: biological_process
def: "Establishment of a pattern of pigment in one sex that is not observed in the other sex." [GOC:jid]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0048066 ! developmental pigmentation
relationship: part_of GO:0007548 ! sex differentiation

[Term]
id: GO:0048072
name: compound eye pigmentation
namespace: biological_process
def: "Establishment of a pattern of pigment in the compound eye." [GOC:jid]
is_a: GO:0048069 ! eye pigmentation

[Term]
id: GO:0048073
name: regulation of eye pigmentation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in the eye of an organism." [GOC:jid]
is_a: GO:0048070 ! regulation of developmental pigmentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048069 ! eye pigmentation
relationship: regulates GO:0048069 ! eye pigmentation

[Term]
id: GO:0048074
name: negative regulation of eye pigmentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of a pattern of pigment in the eye of an organism." [GOC:jid]
synonym: "down regulation of eye pigmentation" EXACT []
synonym: "down-regulation of eye pigmentation" EXACT []
synonym: "downregulation of eye pigmentation" EXACT []
synonym: "inhibition of eye pigmentation" NARROW []
is_a: GO:0048073 ! regulation of eye pigmentation
is_a: GO:0048086 ! negative regulation of developmental pigmentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048069 ! eye pigmentation
relationship: negatively_regulates GO:0048069 ! eye pigmentation

[Term]
id: GO:0048075
name: positive regulation of eye pigmentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in the eye of an organism." [GOC:jid]
synonym: "activation of eye pigmentation" NARROW []
synonym: "stimulation of eye pigmentation" NARROW []
synonym: "up regulation of eye pigmentation" EXACT []
synonym: "up-regulation of eye pigmentation" EXACT []
synonym: "upregulation of eye pigmentation" EXACT []
is_a: GO:0048073 ! regulation of eye pigmentation
is_a: GO:0048087 ! positive regulation of developmental pigmentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048069 ! eye pigmentation
relationship: positively_regulates GO:0048069 ! eye pigmentation

[Term]
id: GO:0048076
name: regulation of compound eye pigmentation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in the compound eye." [GOC:jid]
is_a: GO:0048073 ! regulation of eye pigmentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048072 ! compound eye pigmentation
relationship: regulates GO:0048072 ! compound eye pigmentation

[Term]
id: GO:0048077
name: negative regulation of compound eye pigmentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of a pattern of pigment in the compound eye." [GOC:jid]
synonym: "down regulation of eye pigmentation" BROAD []
synonym: "down-regulation of eye pigmentation" BROAD []
synonym: "downregulation of eye pigmentation" BROAD []
synonym: "inhibition of eye pigmentation" BROAD []
synonym: "negative regulation of eye pigmentation" BROAD []
is_a: GO:0048074 ! negative regulation of eye pigmentation
is_a: GO:0048076 ! regulation of compound eye pigmentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048072 ! compound eye pigmentation
relationship: negatively_regulates GO:0048072 ! compound eye pigmentation

[Term]
id: GO:0048078
name: positive regulation of compound eye pigmentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in the compound eye." [GOC:jid]
synonym: "activation of eye pigmentation" BROAD []
synonym: "positive regulation of eye pigmentation" BROAD []
synonym: "stimulation of eye pigmentation" BROAD []
synonym: "up regulation of eye pigmentation" BROAD []
synonym: "up-regulation of eye pigmentation" BROAD []
synonym: "upregulation of eye pigmentation" BROAD []
is_a: GO:0048075 ! positive regulation of eye pigmentation
is_a: GO:0048076 ! regulation of compound eye pigmentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048072 ! compound eye pigmentation
relationship: positively_regulates GO:0048072 ! compound eye pigmentation

[Term]
id: GO:0048079
name: regulation of cuticle pigmentation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in the cuticle of an organism." [GOC:jid]
is_a: GO:0048070 ! regulation of developmental pigmentation
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048067 ! cuticle pigmentation
relationship: regulates GO:0048067 ! cuticle pigmentation

[Term]
id: GO:0048080
name: negative regulation of cuticle pigmentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of a pattern of pigment in the cuticle of an organism." [GOC:jid]
synonym: "down regulation of cuticle pigmentation" EXACT []
synonym: "down-regulation of cuticle pigmentation" EXACT []
synonym: "downregulation of cuticle pigmentation" EXACT []
synonym: "inhibition of cuticle pigmentation" NARROW []
is_a: GO:0048079 ! regulation of cuticle pigmentation
is_a: GO:0048086 ! negative regulation of developmental pigmentation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048067 ! cuticle pigmentation
relationship: negatively_regulates GO:0048067 ! cuticle pigmentation

[Term]
id: GO:0048081
name: positive regulation of cuticle pigmentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in the cuticle of an organism." [GOC:jid]
synonym: "activation of cuticle pigmentation" NARROW []
synonym: "stimulation of cuticle pigmentation" NARROW []
synonym: "up regulation of cuticle pigmentation" EXACT []
synonym: "up-regulation of cuticle pigmentation" EXACT []
synonym: "upregulation of cuticle pigmentation" EXACT []
is_a: GO:0048079 ! regulation of cuticle pigmentation
is_a: GO:0048087 ! positive regulation of developmental pigmentation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048067 ! cuticle pigmentation
relationship: positively_regulates GO:0048067 ! cuticle pigmentation

[Term]
id: GO:0048082
name: regulation of adult chitin-containing cuticle pigmentation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism." [GOC:jid, GOC:mtg_sensu]
is_a: GO:0007564 ! regulation of chitin-based cuticle tanning
is_a: GO:0048079 ! regulation of cuticle pigmentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048085 ! adult chitin-containing cuticle pigmentation
relationship: regulates GO:0048085 ! adult chitin-containing cuticle pigmentation

[Term]
id: GO:0048083
name: negative regulation of adult chitin-containing cuticle pigmentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism." [GOC:jid, GOC:mtg_sensu]
synonym: "down regulation of adult chitin-containing cuticle pigmentation" EXACT []
synonym: "down-regulation of adult chitin-containing cuticle pigmentation" EXACT []
synonym: "downregulation of adult chitin-containing cuticle pigmentation" EXACT []
synonym: "inhibition of adult chitin-containing cuticle pigmentation" NARROW []
is_a: GO:0045800 ! negative regulation of chitin-based cuticle tanning
is_a: GO:0048080 ! negative regulation of cuticle pigmentation
is_a: GO:0048082 ! regulation of adult chitin-containing cuticle pigmentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048085 ! adult chitin-containing cuticle pigmentation
relationship: negatively_regulates GO:0048085 ! adult chitin-containing cuticle pigmentation

[Term]
id: GO:0048084
name: positive regulation of adult chitin-containing cuticle pigmentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism." [GOC:jid, GOC:mtg_sensu]
synonym: "activation of adult chitin-containing cuticle pigmentation" NARROW []
synonym: "stimulation of adult chitin-containing cuticle pigmentation" NARROW []
synonym: "up regulation of adult chitin-containing cuticle pigmentation" EXACT []
synonym: "up-regulation of adult chitin-containing cuticle pigmentation" EXACT []
synonym: "upregulation of adult chitin-containing cuticle pigmentation" EXACT []
is_a: GO:0045801 ! positive regulation of chitin-based cuticle tanning
is_a: GO:0048081 ! positive regulation of cuticle pigmentation
is_a: GO:0048082 ! regulation of adult chitin-containing cuticle pigmentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048085 ! adult chitin-containing cuticle pigmentation
relationship: positively_regulates GO:0048085 ! adult chitin-containing cuticle pigmentation

[Term]
id: GO:0048085
name: adult chitin-containing cuticle pigmentation
namespace: biological_process
alt_id: GO:0048068
def: "Establishment of the adult pattern of pigmentation in the chitin-containing cuticle of an organism. An example of this is the adult cuticle pigmentation process in Drosophila melanogaster." [GOC:jid, GOC:mtg_sensu]
synonym: "adult cuticle pigmentation" BROAD []
is_a: GO:0048067 ! cuticle pigmentation
relationship: part_of GO:0007593 ! chitin-based cuticle sclerotization

[Term]
id: GO:0048086
name: negative regulation of developmental pigmentation
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism." [GOC:dph, GOC:jid, GOC:tb]
synonym: "down regulation of developmental pigmentation" EXACT [GOC:dph, GOC:tb]
synonym: "down-regulation of developmental pigmentation" EXACT [GOC:dph, GOC:tb]
synonym: "downregulation of developmental pigmentation" EXACT [GOC:dph, GOC:tb]
synonym: "inhibition of pigmentation" NARROW []
is_a: GO:0048070 ! regulation of developmental pigmentation
is_a: GO:0051093 ! negative regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048066 ! developmental pigmentation
relationship: negatively_regulates GO:0048066 ! developmental pigmentation

[Term]
id: GO:0048087
name: positive regulation of developmental pigmentation
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism." [GOC:dph, GOC:jid, GOC:tb]
synonym: "activation of developmental pigmentation" NARROW [GOC:dph, GOC:tb]
synonym: "stimulation of developmental pigmentation" NARROW [GOC:dph, GOC:tb]
synonym: "up regulation of developmental pigmentation" EXACT [GOC:dph]
synonym: "up-regulation of developmental pigmentation" EXACT [GOC:dph, GOC:tb]
synonym: "upregulation of developmental pigmentation" EXACT [GOC:dph, goc:tb]
is_a: GO:0048070 ! regulation of developmental pigmentation
is_a: GO:0051094 ! positive regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048066 ! developmental pigmentation
relationship: positively_regulates GO:0048066 ! developmental pigmentation

[Term]
id: GO:0048088
name: regulation of male pigmentation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in males." [GOC:jid]
is_a: GO:0048070 ! regulation of developmental pigmentation
is_a: GO:2000026 ! regulation of multicellular organismal development
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048094 ! male pigmentation
relationship: regulates GO:0048094 ! male pigmentation

[Term]
id: GO:0048089
name: regulation of female pigmentation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in females." [GOC:jid]
is_a: GO:0048070 ! regulation of developmental pigmentation
is_a: GO:2000026 ! regulation of multicellular organismal development
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048095 ! female pigmentation
relationship: regulates GO:0048095 ! female pigmentation

[Term]
id: GO:0048090
name: negative regulation of female pigmentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of a pattern of pigment in females." [GOC:jid]
synonym: "down regulation of female pigmentation" EXACT []
synonym: "down-regulation of female pigmentation" EXACT []
synonym: "downregulation of female pigmentation" EXACT []
synonym: "inhibition of female pigmentation" NARROW []
is_a: GO:0048086 ! negative regulation of developmental pigmentation
is_a: GO:0048089 ! regulation of female pigmentation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000242 ! negative regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048095 ! female pigmentation
relationship: negatively_regulates GO:0048095 ! female pigmentation

[Term]
id: GO:0048091
name: positive regulation of female pigmentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in females." [GOC:jid]
synonym: "activation of female pigmentation" NARROW []
synonym: "stimulation of female pigmentation" NARROW []
synonym: "up regulation of female pigmentation" EXACT []
synonym: "up-regulation of female pigmentation" EXACT []
synonym: "upregulation of female pigmentation" EXACT []
is_a: GO:0048087 ! positive regulation of developmental pigmentation
is_a: GO:0048089 ! regulation of female pigmentation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000243 ! positive regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048095 ! female pigmentation
relationship: positively_regulates GO:0048095 ! female pigmentation

[Term]
id: GO:0048092
name: negative regulation of male pigmentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of a pattern of pigment in males." [GOC:jid]
synonym: "down regulation of male pigmentation" EXACT []
synonym: "down-regulation of male pigmentation" EXACT []
synonym: "downregulation of male pigmentation" EXACT []
synonym: "inhibition of male pigmentation" NARROW []
is_a: GO:0048086 ! negative regulation of developmental pigmentation
is_a: GO:0048088 ! regulation of male pigmentation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000242 ! negative regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048094 ! male pigmentation
relationship: negatively_regulates GO:0048094 ! male pigmentation

[Term]
id: GO:0048093
name: positive regulation of male pigmentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in males." [GOC:jid]
synonym: "activation of male pigmentation" NARROW []
synonym: "stimulation of male pigmentation" NARROW []
synonym: "up regulation of male pigmentation" EXACT []
synonym: "up-regulation of male pigmentation" EXACT []
synonym: "upregulation of male pigmentation" EXACT []
is_a: GO:0048087 ! positive regulation of developmental pigmentation
is_a: GO:0048088 ! regulation of male pigmentation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000243 ! positive regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048094 ! male pigmentation
relationship: positively_regulates GO:0048094 ! male pigmentation

[Term]
id: GO:0048094
name: male pigmentation
namespace: biological_process
def: "Establishment of a pattern of pigment in males." [GOC:jid]
is_a: GO:0048071 ! sex-specific pigmentation
relationship: part_of GO:0046661 ! male sex differentiation

[Term]
id: GO:0048095
name: female pigmentation
namespace: biological_process
def: "Establishment of a pattern of pigment in females." [GOC:jid]
is_a: GO:0048071 ! sex-specific pigmentation
relationship: part_of GO:0046660 ! female sex differentiation

[Term]
id: GO:0048096
name: chromatin-mediated maintenance of transcription
namespace: biological_process
def: "Maintenance of transcription by remodelling of chromatin into an 'open configuration'. Once established, this regulation is mitotically stable and is maintained over many cell divisions. It is also heritable." [GOC:jid]
comment: Note that this process is the opposite of chromatin silencing. This regulation is exemplified by members of the trithorax group, which maintain the active state of homeotic gene transcription.
is_a: GO:0006338 ! chromatin remodeling
is_a: GO:0045815 ! positive regulation of gene expression, epigenetic
is_a: GO:0045893 ! positive regulation of transcription, DNA-templated

[Term]
id: GO:0048097
name: long-term maintenance of gene activation
namespace: biological_process
def: "Any mechanism, at the level of transcription or post-transcription, maintaining gene activation in the long-term." [GOC:jid]
comment: Note that this process is the opposite of gene silencing.
is_a: GO:0045815 ! positive regulation of gene expression, epigenetic

[Term]
id: GO:0048098
name: antennal joint development
namespace: biological_process
def: "The process whose specific outcome is the progression of the antennal joint over time, from its formation to the mature structure. The antennal joint is the joint between antennal segments." [GOC:jid]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007469 ! antennal development

[Term]
id: GO:0048099
name: anterior/posterior lineage restriction, imaginal disc
namespace: biological_process
def: "Formation and/or maintenance of a lineage boundary between anterior and posterior compartments that cells cannot cross, thus separating the populations of cells in each compartment." [GOC:jid, PMID:10625531, PMID:9374402]
is_a: GO:0035161 ! imaginal disc lineage restriction
relationship: part_of GO:0007448 ! anterior/posterior pattern specification, imaginal disc

[Term]
id: GO:0048100
name: wing disc anterior/posterior pattern formation
namespace: biological_process
def: "The establishment, maintenance and elaboration of the anterior/posterior axis of the wing disc, a precursor to the wing." [GOC:jid, PMID:10625531]
is_a: GO:0007448 ! anterior/posterior pattern specification, imaginal disc
is_a: GO:0035222 ! wing disc pattern formation

[Term]
id: GO:0048101
name: calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate. The reaction is calmodulin and calcium-sensitive." [GOC:jid]
synonym: "calcium- and calmodulin-regulated cGMP phosphodiesterase activity" RELATED []
synonym: "calcium- and calmodulin-regulated cGMP-specific phosphodiesterase activity" EXACT []
synonym: "calcium- and calmodulin-regulated cyclic-GMP phosphodiesterase activity" EXACT []
synonym: "calcium/calmodulin-regulated cGMP-specific phosphodiesterase activity" EXACT []
is_a: GO:0047555 ! 3',5'-cyclic-GMP phosphodiesterase activity

[Term]
id: GO:0048102
name: autophagic cell death
namespace: biological_process
def: "A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, GOC:mtg_apoptosis, PMID:18846107, PMID:23347517]
comment: The precise nature of autophagic cell death is still being debated, and the link between autophagy and cell death unclear. As autophagy is often induced under conditions of stress that could also lead to cell death, there has been a propagation of the idea that autophagy can act as a cell death mechanism; but others suggest that autophagy may simply be an attempt of dying cells to adapt to lethal stress rather than a mechanism to execute a cell death program. Further studies are required to resolve this controversy (see e.g. PMID:22082964, PMID:22052193, PMID:25236395). In the meantime, curators should carefully examine the experimental evidence presented in papers concerning autophagic cell death, and annotate accordingly. Recently, an instance of autophagic cell death, termed autosis, was discovered that relies on the plasma membrane Na+/K+-ATPase. Autosis was observed in vivo in the brain of rats subjected to an ischemic insult. It's still unclear if all cases of autophagic cell death require the Na+/K+-ATPase or not.
synonym: "autophagic death" BROAD []
synonym: "autosis" RELATED [PMID:25236395]
synonym: "programmed cell death by autophagy" BROAD [GOC:pr]
synonym: "programmed cell death by macroautophagy" EXACT [GOC:cjm]
synonym: "type II programmed cell death" RELATED [GOC:sl]
is_a: GO:0012501 ! programmed cell death
intersection_of: GO:0012501 ! programmed cell death
intersection_of: has_part GO:0016236 ! macroautophagy
relationship: has_part GO:0016236 ! macroautophagy

[Term]
id: GO:0048103
name: somatic stem cell division
namespace: biological_process
def: "The self-renewing division of a somatic stem cell, a stem cell that can give rise to cell types of the body other than those of the germ-line." [GOC:jid, ISBN:0582227089]
synonym: "somatic stem cell renewal" EXACT []
is_a: GO:0017145 ! stem cell division

[Term]
id: GO:0048104
name: establishment of body hair or bristle planar orientation
namespace: biological_process
def: "Orientation of hairs or sensory bristles that cover the body surface of an adult, such that they all point in a uniform direction along the plane of the epithelium from which they project." [GOC:ascb_2009, GOC:dph, GOC:jid, GOC:tb]
is_a: GO:0001736 ! establishment of planar polarity

[Term]
id: GO:0048105
name: establishment of body hair planar orientation
namespace: biological_process
def: "Orientation of body hairs, projections from the surface of an organism, such that the hairs all point in a uniform direction along the surface." [GOC:ascb_2009, GOC:dph, GOC:jid, GOC:tb]
is_a: GO:0048104 ! establishment of body hair or bristle planar orientation

[Term]
id: GO:0048106
name: establishment of thoracic bristle planar orientation
namespace: biological_process
def: "Orientation along the body surface of bristles, sensory organs originating from a sensory organ precursor cell, such that they all point in a uniform direction." [FBbt:00004298, FBbt:00004408, GOC:ascb_2009, GOC:dph, GOC:jid, GOC:tb]
synonym: "establishment of body bristle planar orientation" EXACT [GOC:bf]
is_a: GO:0048104 ! establishment of body hair or bristle planar orientation
relationship: part_of GO:0008407 ! chaeta morphogenesis

[Term]
id: GO:0048107
name: 4-amino-3-isothiazolidinone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 4-amino-3-isothiazolinone, five-membered saturated heterocyclic ring structures containing a sulfur and a nitrogen in the 1-position and 2-positions respectively." [GOC:jid]
subset: gosubset_prok
synonym: "4-amino-3-isothiazolidinone anabolism" EXACT []
synonym: "4-amino-3-isothiazolidinone biosynthesis" EXACT []
synonym: "4-amino-3-isothiazolidinone formation" EXACT []
synonym: "4-amino-3-isothiazolidinone synthesis" EXACT []
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process

[Term]
id: GO:0048108
name: peptide cross-linking via 4-amino-3-isothiazolidinone
namespace: biological_process
def: "The formation of 4-amino-3-isothiazolinone cross-links by the formation of a sulfenylamide bond between cysteine or cysteine sulfenic acid, and the alpha-amido of the following residue." [GOC:jid, GOC:jsg]
comment: Note that this is a generic parent because the identity of the second amino acid is not critical for formation of the cross-link.
subset: gosubset_prok
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0048109
name: peptide cross-linking via 2-amino-3-isothiazolidinone-L-serine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl serine cross-link through a process of forming first an intermediate cysteine sulfenic acid by peroxide oxidation, followed by condensation with the alpha-amido of the following serine residue and the release of water." [GOC:jid, PMID:12802338, PMID:12802339, RESID:AA0344]
subset: gosubset_prok
xref: RESID:AA0344
is_a: GO:0018209 ! peptidyl-serine modification
is_a: GO:0048108 ! peptide cross-linking via 4-amino-3-isothiazolidinone

[Term]
id: GO:0048132
name: female germ-line stem cell asymmetric division
namespace: biological_process
alt_id: GO:0048141
def: "The self-renewing division of a germline stem cell in the female gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the female gametes." [GOC:jid, GOC:mtg_sensu]
synonym: "female germ-line stem cell renewal" EXACT []
is_a: GO:0098728 ! germline stem cell asymmetric division
relationship: part_of GO:0048477 ! oogenesis

[Term]
id: GO:0048133
name: male germ-line stem cell asymmetric division
namespace: biological_process
def: "The self-renewing division of a germline stem cell in the male gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the male gametes." [GOC:jid]
synonym: "male germ-line stem cell renewal" EXACT []
is_a: GO:0098728 ! germline stem cell asymmetric division
relationship: part_of GO:0007283 ! spermatogenesis

[Term]
id: GO:0048134
name: germ-line cyst formation
namespace: biological_process
def: "Formation of a group of interconnected cells derived from a single gonial founder cell." [GOC:jid, PMID:10370240, PMID:21681920]
synonym: "germline cyst formation" EXACT [PMID:10370240]
is_a: GO:0008283 ! cell proliferation
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
relationship: part_of GO:0007281 ! germ cell development

[Term]
id: GO:0048135
name: female germ-line cyst formation
namespace: biological_process
def: "Formation of a group of interconnected cells derived from a single female gonial founder cell." [GOC:jid, PMID:10370240]
synonym: "female germline cyst formation" EXACT [PMID:10370240]
is_a: GO:0048134 ! germ-line cyst formation
relationship: part_of GO:0048477 ! oogenesis

[Term]
id: GO:0048136
name: male germ-line cyst formation
namespace: biological_process
def: "Formation of a group of interconnected cells derived from a single male gonial founder cell." [GOC:jid, PMID:10370240]
synonym: "male germline cyst formation" EXACT [PMID:10370240]
is_a: GO:0048134 ! germ-line cyst formation
relationship: has_part GO:0007284 ! spermatogonial cell division
relationship: has_part GO:0048137 ! spermatocyte division
relationship: part_of GO:0007283 ! spermatogenesis

[Term]
id: GO:0048137
name: spermatocyte division
namespace: biological_process
def: "The meiotic divisions undergone by the primary and secondary spermatocytes to produce haploid spermatids." [GOC:jid, GOC:pr, ISBN:0879694238]
synonym: "spermatocyte cell division" EXACT []
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0051301 ! cell division
relationship: part_of GO:0007283 ! spermatogenesis

[Term]
id: GO:0048138
name: germ-line cyst encapsulation
namespace: biological_process
def: "Formation of a single follicular epithelium around the germ-line derived cells of a cyst." [GOC:jid]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007276 ! gamete generation
relationship: part_of GO:0016333 ! morphogenesis of follicular epithelium

[Term]
id: GO:0048139
name: female germ-line cyst encapsulation
namespace: biological_process
def: "Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the female gonad." [GOC:jid]
is_a: GO:0048138 ! germ-line cyst encapsulation
relationship: part_of GO:0007292 ! female gamete generation

[Term]
id: GO:0048140
name: male germ-line cyst encapsulation
namespace: biological_process
def: "Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the male gonad." [GOC:jid, PMID:11591336]
is_a: GO:0048138 ! germ-line cyst encapsulation
relationship: part_of GO:0007283 ! spermatogenesis

[Term]
id: GO:0048142
name: germarium-derived cystoblast division
namespace: biological_process
def: "The four rounds of incomplete mitosis undergone by a cystoblast to form a 16-cell cyst of interconnected cells within a germarium. Within the cyst, one cell differentiates into an oocyte while the rest become nurse cells. An example of this process is found in Drosophila melanogaster." [GOC:jid, GOC:mtg_sensu, PMID:11131529]
synonym: "germarium-derived cystoblast cell division" EXACT []
is_a: GO:0007282 ! cystoblast division
relationship: part_of GO:0030727 ! germarium-derived female germ-line cyst formation

[Term]
id: GO:0048143
name: astrocyte activation
namespace: biological_process
def: "A change in morphology and behavior of an astrocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, PMID:10526094, PMID:10695728, PMID:12529254, PMID:12580336, PMID:9585813]
is_a: GO:0001775 ! cell activation
relationship: part_of GO:0014002 ! astrocyte development

[Term]
id: GO:0048144
name: fibroblast proliferation
namespace: biological_process
def: "The multiplication or reproduction of fibroblast cells, resulting in the expansion of the fibroblast population." [GOC:jid]
is_a: GO:0008283 ! cell proliferation

[Term]
id: GO:0048145
name: regulation of fibroblast proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of multiplication or reproduction of fibroblast cells." [GOC:jid]
is_a: GO:0042127 ! regulation of cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048144 ! fibroblast proliferation
relationship: regulates GO:0048144 ! fibroblast proliferation

[Term]
id: GO:0048146
name: positive regulation of fibroblast proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells." [GOC:jid]
synonym: "activation of fibroblast proliferation" NARROW []
synonym: "stimulation of fibroblast proliferation" NARROW []
synonym: "up regulation of fibroblast proliferation" EXACT []
synonym: "up-regulation of fibroblast proliferation" EXACT []
synonym: "upregulation of fibroblast proliferation" EXACT []
is_a: GO:0008284 ! positive regulation of cell proliferation
is_a: GO:0048145 ! regulation of fibroblast proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048144 ! fibroblast proliferation
relationship: positively_regulates GO:0048144 ! fibroblast proliferation

[Term]
id: GO:0048147
name: negative regulation of fibroblast proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells." [GOC:jid]
synonym: "down regulation of fibroblast proliferation" EXACT []
synonym: "down-regulation of fibroblast proliferation" EXACT []
synonym: "downregulation of fibroblast proliferation" EXACT []
synonym: "inhibition of fibroblast proliferation" NARROW []
is_a: GO:0008285 ! negative regulation of cell proliferation
is_a: GO:0048145 ! regulation of fibroblast proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048144 ! fibroblast proliferation
relationship: negatively_regulates GO:0048144 ! fibroblast proliferation

[Term]
id: GO:0048148
name: behavioral response to cocaine
namespace: biological_process
def: "Any process that results in a change in the behavior of an organism as a result of a cocaine stimulus." [GOC:jid]
synonym: "behavioural response to cocaine" EXACT []
is_a: GO:0030534 ! adult behavior
relationship: part_of GO:0042220 ! response to cocaine

[Term]
id: GO:0048149
name: behavioral response to ethanol
namespace: biological_process
def: "Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid]
synonym: "behavioural response to ethanol" EXACT []
is_a: GO:0030534 ! adult behavior
relationship: part_of GO:0045471 ! response to ethanol

[Term]
id: GO:0048150
name: behavioral response to ether
namespace: biological_process
def: "Any process that results in a change in the behavior of an organism as a result of an ether stimulus." [GOC:jid]
synonym: "behavioural response to ether" EXACT []
is_a: GO:0030534 ! adult behavior
relationship: part_of GO:0045472 ! response to ether

[Term]
id: GO:0048151
name: obsolete hyperphosphorylation
namespace: biological_process
def: "OBSOLETE. The excessive phosphorylation of a protein, as a result of activation of kinases, deactivation of phosphatases, or both." [GOC:jid, ISBN:039751820X, PMID:12859672]
comment: This term was made obsolete because it is an unnecessary grouping term and was poorly defined.
synonym: "hyperphosphorylation" EXACT []
is_obsolete: true
replaced_by: GO:0016310

[Term]
id: GO:0048152
name: S100 beta biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of S100 beta protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS." [GOC:jid]
synonym: "S100 beta anabolism" EXACT []
synonym: "S100 beta biosynthesis" EXACT []
synonym: "S100 beta formation" EXACT []
synonym: "S100 beta synthesis" EXACT []
is_a: GO:0009059 ! macromolecule biosynthetic process

[Term]
id: GO:0048153
name: S100 alpha biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of S100 alpha protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS." [GOC:jid]
synonym: "S100 alpha anabolism" EXACT []
synonym: "S100 alpha biosynthesis" EXACT []
synonym: "S100 alpha formation" EXACT []
synonym: "S100 alpha synthesis" EXACT []
is_a: GO:0009059 ! macromolecule biosynthetic process

[Term]
id: GO:0048156
name: tau protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS." [GOC:jid]
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0048158
name: oogonium stage
namespace: biological_process
def: "The stage in mammalian oogenesis when the primordial germ cell is hardly distinguishable from other cortical cells of the ovary." [GOC:jid, GOC:mtg_sensu, ISBN:0198542771]
synonym: "mammalian oogenesis stage 1" EXACT []
is_a: GO:0022605 ! oogenesis stage

[Term]
id: GO:0048159
name: primary oocyte stage
namespace: biological_process
def: "The stage in oogenesis when the oocyte has a nucleus slightly larger than those of the adjacent cells and is surrounded by a layer of loose squamous epithelial cells." [GOC:jid, GOC:mtg_sensu, ISBN:0198542771]
synonym: "mammalian oogenesis stage 2" EXACT []
is_a: GO:0022605 ! oogenesis stage

[Term]
id: GO:0048160
name: primary follicle stage
namespace: biological_process
def: "The stage in oogenesis when a single layer of cuboidal follicle cells surrounds the oocyte. The oocyte nucleus is large." [GOC:jid, GOC:mtg_sensu, ISBN:0198542771]
synonym: "mammalian oogenesis stage 3" EXACT []
is_a: GO:0022605 ! oogenesis stage

[Term]
id: GO:0048161
name: double layer follicle stage
namespace: biological_process
def: "The stage in oogenesis when a double layer of distinct follicle cells surrounds the oocyte. An example of this process is found in Mus musculus." [GOC:jid, GOC:mtg_sensu, ISBN:0198542771]
synonym: "mammalian oogenesis stage 4" EXACT []
is_a: GO:0022605 ! oogenesis stage

[Term]
id: GO:0048162
name: multi-layer follicle stage
namespace: biological_process
def: "The stage in oogenesis when many layers of follicle cells surround the oocyte. There is a yolk nucleus (Balbiani's Body) near the germinal vesicle." [GOC:jid, GOC:mtg_sensu, ISBN:0198542771]
synonym: "mammalian oogenesis stage 5" EXACT []
is_a: GO:0022605 ! oogenesis stage

[Term]
id: GO:0048163
name: scattered antral spaces stage
namespace: biological_process
def: "The stage in oogenesis when antral spaces begin to form in the follicle cells. Mitochondria form centers for yolk concentration." [GOC:jid, GOC:mtg_sensu, ISBN:0198542771]
synonym: "mammalian oogenesis stage 6" EXACT []
is_a: GO:0022605 ! oogenesis stage

[Term]
id: GO:0048164
name: distinct antral spaces stage
namespace: biological_process
def: "The stage in oogenesis when the antral spaces become distinct and the first polar body forms." [GOC:jid, GOC:mtg_sensu, ISBN:0198542771]
synonym: "mammalian oogenesis stage 7" EXACT []
is_a: GO:0022605 ! oogenesis stage

[Term]
id: GO:0048165
name: fused antrum stage
namespace: biological_process
def: "The stage in oogenesis when the antral spaces fuse to form a single antral space. The oocyte is suspended in the cumulus oophorous and the first polar body in the perivitelline space." [GOC:jid, GOC:mtg_sensu, ISBN:0198542771]
synonym: "mammalian oogenesis stage 8" EXACT []
is_a: GO:0022605 ! oogenesis stage

[Term]
id: GO:0048166
name: mature follicle stage
namespace: biological_process
def: "The stage in oogenesis when the antrum is swollen with follicular fluid. The ovum is ready to erupt from the ovary and is arrested at metaphase of the second meiotic division." [GOC:jid, GOC:mtg_sensu, ISBN:0198542771]
synonym: "mammalian oogenesis stage 9" EXACT []
is_a: GO:0022605 ! oogenesis stage

[Term]
id: GO:0048167
name: regulation of synaptic plasticity
namespace: biological_process
def: "A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:dph, GOC:jid, GOC:tb, http://www.mercksource.com, PMID:11891290]
comment: Note that the syntax of the definition of the this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process.
is_a: GO:0050803 ! regulation of synapse structure or activity
is_a: GO:0050804 ! modulation of synaptic transmission

[Term]
id: GO:0048168
name: regulation of neuronal synaptic plasticity
namespace: biological_process
def: "A process that modulates neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:jid, http://www.mercksource.com, PMID:11891290]
comment: Note that the syntax of the definition of the this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process.
is_a: GO:0048167 ! regulation of synaptic plasticity

[Term]
id: GO:0048169
name: regulation of long-term neuronal synaptic plasticity
namespace: biological_process
def: "A process that modulates long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers." [GOC:jid, http://www.mercksource.com, PMID:11891290]
comment: Note that the syntax of the definition of the this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process.
is_a: GO:0048168 ! regulation of neuronal synaptic plasticity

[Term]
id: GO:0048170
name: positive regulation of long-term neuronal synaptic plasticity
namespace: biological_process
def: "A process that increases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers." [GOC:jid, http://www.mercksource.com, PMID:11891290]
comment: Note that the syntax of the definition of the this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process.
synonym: "activation of long-term neuronal synaptic plasticity" NARROW []
synonym: "stimulation of long-term neuronal synaptic plasticity" NARROW []
synonym: "up regulation of long-term neuronal synaptic plasticity" EXACT []
synonym: "up-regulation of long-term neuronal synaptic plasticity" EXACT []
synonym: "upregulation of long-term neuronal synaptic plasticity" EXACT []
is_a: GO:0048169 ! regulation of long-term neuronal synaptic plasticity
is_a: GO:0050769 ! positive regulation of neurogenesis

[Term]
id: GO:0048171
name: negative regulation of long-term neuronal synaptic plasticity
namespace: biological_process
def: "A process that decreases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers." [GOC:jid, http://www.mercksource.com, PMID:11891290]
comment: Note that the syntax of the definition of the this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process.
synonym: "down regulation of long-term neuronal synaptic plasticity" EXACT []
synonym: "down-regulation of long-term neuronal synaptic plasticity" EXACT []
synonym: "downregulation of long-term neuronal synaptic plasticity" EXACT []
synonym: "inhibition of long-term neuronal synaptic plasticity" NARROW []
is_a: GO:0048169 ! regulation of long-term neuronal synaptic plasticity
is_a: GO:0050768 ! negative regulation of neurogenesis

[Term]
id: GO:0048172
name: regulation of short-term neuronal synaptic plasticity
namespace: biological_process
def: "A process that modulates short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity." [GOC:jid, http://www.mercksource.com, PMID:11891290]
comment: Note that the syntax of the definition of the this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process.
is_a: GO:0048168 ! regulation of neuronal synaptic plasticity

[Term]
id: GO:0048173
name: positive regulation of short-term neuronal synaptic plasticity
namespace: biological_process
def: "A process that increases short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity." [GOC:jid, http://www.mercksource.com, PMID:11891290]
comment: Note that the syntax of the definition of the this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process.
synonym: "activation of short-term neuronal synaptic plasticity" NARROW []
synonym: "stimulation of short-term neuronal synaptic plasticity" NARROW []
synonym: "up regulation of short-term neuronal synaptic plasticity" EXACT []
synonym: "up-regulation of short-term neuronal synaptic plasticity" EXACT []
synonym: "upregulation of short-term neuronal synaptic plasticity" EXACT []
is_a: GO:0048172 ! regulation of short-term neuronal synaptic plasticity
is_a: GO:0050769 ! positive regulation of neurogenesis

[Term]
id: GO:0048174
name: negative regulation of short-term neuronal synaptic plasticity
namespace: biological_process
def: "A process that decreases short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity." [GOC:jid, http://www.mercksource.com, PMID:11891290]
comment: Note that the syntax of the definition of the this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process.
synonym: "down regulation of short-term neuronal synaptic plasticity" EXACT []
synonym: "down-regulation of short-term neuronal synaptic plasticity" EXACT []
synonym: "downregulation of short-term neuronal synaptic plasticity" EXACT []
synonym: "inhibition of short-term neuronal synaptic plasticity" NARROW []
is_a: GO:0048172 ! regulation of short-term neuronal synaptic plasticity
is_a: GO:0050768 ! negative regulation of neurogenesis

[Term]
id: GO:0048175
name: hepatocyte growth factor biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of hepacyte growth factor. Hepatocyte growth factor is a mitogen for a number of cell types and it is found in liver cells and in many other cell types, including platelets." [GOC:jid, PMID:1838014]
synonym: "hepatocyte growth factor anabolism" EXACT []
synonym: "hepatocyte growth factor biosynthesis" EXACT []
synonym: "hepatocyte growth factor formation" EXACT []
synonym: "hepatocyte growth factor synthesis" EXACT []
synonym: "HGF biosynthesis" EXACT []
synonym: "HGF biosynthetic process" EXACT []
synonym: "scatter factor biosynthesis" EXACT []
synonym: "scatter factor biosynthetic process" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032605 ! hepatocyte growth factor production

[Term]
id: GO:0048176
name: regulation of hepatocyte growth factor biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hepatocyte growth factor." [GOC:jid, PMID:1838014]
synonym: "regulation of hepatocyte growth factor anabolism" EXACT []
synonym: "regulation of hepatocyte growth factor biosynthesis" EXACT []
synonym: "regulation of hepatocyte growth factor formation" EXACT []
synonym: "regulation of hepatocyte growth factor synthesis" EXACT []
synonym: "regulation of HGF biosynthesis" EXACT []
synonym: "regulation of HGF biosynthetic process" EXACT []
synonym: "regulation of scatter factor biosynthesis" EXACT []
synonym: "regulation of scatter factor biosynthetic process" EXACT []
is_a: GO:0032646 ! regulation of hepatocyte growth factor production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048175 ! hepatocyte growth factor biosynthetic process
relationship: regulates GO:0048175 ! hepatocyte growth factor biosynthetic process

[Term]
id: GO:0048177
name: positive regulation of hepatocyte growth factor biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hepatocyte growth factor." [GOC:jid, PMID:1838014]
synonym: "activation of hepatocyte growth factor biosynthetic process" NARROW []
synonym: "positive regulation of hepatocyte growth factor anabolism" EXACT []
synonym: "positive regulation of hepatocyte growth factor biosynthesis" EXACT []
synonym: "positive regulation of hepatocyte growth factor formation" EXACT []
synonym: "positive regulation of hepatocyte growth factor synthesis" EXACT []
synonym: "positive regulation of HGF biosynthesis" EXACT []
synonym: "positive regulation of HGF biosynthetic process" EXACT []
synonym: "positive regulation of scatter factor biosynthesis" EXACT []
synonym: "positive regulation of scatter factor biosynthetic process" EXACT []
synonym: "stimulation of hepatocyte growth factor biosynthetic process" NARROW []
synonym: "up regulation of hepatocyte growth factor biosynthetic process" EXACT []
synonym: "up-regulation of hepatocyte growth factor biosynthetic process" EXACT []
synonym: "upregulation of hepatocyte growth factor biosynthetic process" EXACT []
is_a: GO:0032726 ! positive regulation of hepatocyte growth factor production
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0048176 ! regulation of hepatocyte growth factor biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048175 ! hepatocyte growth factor biosynthetic process
relationship: positively_regulates GO:0048175 ! hepatocyte growth factor biosynthetic process

[Term]
id: GO:0048178
name: negative regulation of hepatocyte growth factor biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hepatocyte growth factor." [GOC:jid, PMID:1838014]
synonym: "down regulation of hepatocyte growth factor biosynthetic process" EXACT []
synonym: "down-regulation of hepatocyte growth factor biosynthetic process" EXACT []
synonym: "downregulation of hepatocyte growth factor biosynthetic process" EXACT []
synonym: "inhibition of hepatocyte growth factor biosynthetic process" NARROW []
synonym: "negative regulation of hepatocyte growth factor anabolism" EXACT []
synonym: "negative regulation of hepatocyte growth factor biosynthesis" EXACT []
synonym: "negative regulation of hepatocyte growth factor formation" EXACT []
synonym: "negative regulation of hepatocyte growth factor synthesis" EXACT []
synonym: "negative regulation of HGF biosynthesis" EXACT []
synonym: "negative regulation of HGF biosynthetic process" EXACT []
synonym: "negative regulation of scatter factor biosynthesis" EXACT []
synonym: "negative regulation of scatter factor biosynthetic process" EXACT []
is_a: GO:0032686 ! negative regulation of hepatocyte growth factor production
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0048176 ! regulation of hepatocyte growth factor biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048175 ! hepatocyte growth factor biosynthetic process
relationship: negatively_regulates GO:0048175 ! hepatocyte growth factor biosynthetic process

[Term]
id: GO:0048179
name: activin receptor complex
namespace: cellular_component
def: "A protein complex that acts as an activin receptor. Heterodimeric activin receptors, comprising one Type I activin receptor and one Type II receptor polypeptide, and heterotrimeric receptors have been observed." [PMID:8307945, PMID:8622651]
is_a: GO:0098802 ! plasma membrane receptor complex
is_a: GO:1902554 ! serine/threonine protein kinase complex
relationship: part_of GO:0005887 ! integral component of plasma membrane

[Term]
id: GO:0048180
name: activin complex
namespace: cellular_component
def: "A nonsteroidal regulator, composed of two covalently linked inhibin beta subunits, inhibin beta-A and inhibin beta-B (sometimes known as activin beta or activin/inhibin beta). There are three forms of activin complex, activin A, which is composed of 2 inhibin beta-A subunits, activin B, which is composed of 2 inhibin beta-B subunits, and activin AB, which is composed of an inhibin beta-A and an inhibin beta-B subunit." [GOC:go_curators, http://www.mercksource.com, http://www.stedmans.com/]
comment: Note that the actions of the activin complex are the opposite of those of the inhibin complex, which is a dimer of an inhibin beta-A or inhibin beta-B subunit and a inhibin alpha subunit. See 'inhibin complex ; GO:0043511'.
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0048183
name: activin AB complex
namespace: cellular_component
def: "A nonsteroidal regulator, composed of two covalently linked inhibin beta subunits (sometimes known as activin beta or activin/inhibin beta), inhibin beta-A and inhibin beta-B." [GOC:go_curators, http://www.mercksource.com, http://www.stedmans.com/]
comment: Note that the actions of the activin complex are the opposite of those of the inhibin complex, which is a dimer of an inhibin beta-A or inhibin beta-B subunit and a inhibin alpha subunit. See 'inhibin complex ; GO:0043511'.
synonym: "inhibin beta-A" NARROW []
synonym: "inhibin beta-B" NARROW []
is_a: GO:0048180 ! activin complex

[Term]
id: GO:0048184
name: obsolete follistatin binding
namespace: molecular_function
def: "OBSOLETE. Interacting selectively and non-covalently with the peptide hormone follistatin." [GOC:jid, GOC:mah]
comment: This term was made obsolete because it represents binding to an individual protein.
synonym: "follistatin binding" EXACT []
is_obsolete: true
replaced_by: GO:0017046

[Term]
id: GO:0048185
name: activin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with activin, a dimer of inhibin-beta subunits." [GOC:jid, GOC:mah]
is_a: GO:0032403 ! protein complex binding

[Term]
id: GO:0048188
name: Set1C/COMPASS complex
namespace: cellular_component
def: "A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30." [PMID:11687631, PMID:11742990, PMID:11805083, PMID:12488447, PMID:18508253, PMID:18838538]
synonym: "COMPASS complex" EXACT [GOC:vw]
synonym: "Set1/COMPASS complex" EXACT [GOC:mah]
synonym: "Set1C" EXACT [GOC:vw]
is_a: GO:0035097 ! histone methyltransferase complex

[Term]
id: GO:0048189
name: Lid2 complex
namespace: cellular_component
def: "A protein complex that is thought to be involved in regulation of chromatin remodeling. In Schizosaccharomyces the complex contains Lid1p, Ash2p, Ecm5p, Snt2p, and Sdc1p." [PMID:12488447]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0048190
name: wing disc dorsal/ventral pattern formation
namespace: biological_process
def: "The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid]
synonym: "wing disc dorsal-ventral pattern formation" EXACT [GOC:mah]
synonym: "wing disc dorsoventral pattern formation" EXACT [GOC:mah]
is_a: GO:0007450 ! dorsal/ventral pattern formation, imaginal disc
is_a: GO:0035222 ! wing disc pattern formation

[Term]
id: GO:0048191
name: obsolete peptide stabilization activity
namespace: molecular_function
def: "OBSOLETE. Strengthening of a bond between peptides. Peptides are compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:jid]
comment: This term was made obsolete because it represents a biological process.
synonym: "peptide stabilization activity" EXACT []
is_obsolete: true
replaced_by: GO:0050822

[Term]
id: GO:0048192
name: obsolete peptide antigen stabilization activity
namespace: molecular_function
def: "OBSOLETE. Strengthening of a bond with a peptide antigen; a fragment of a foreign protein derived by proteolysis within the cell." [GOC:jid]
comment: This term was made obsolete because it represents a biological process.
synonym: "peptide antigen stabilization activity" EXACT []
is_obsolete: true
replaced_by: GO:0050823

[Term]
id: GO:0048193
name: Golgi vesicle transport
namespace: biological_process
def: "The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233]
subset: goslim_yeast
synonym: "Golgi-derived vesicle transport" RELATED []
is_a: GO:0016192 ! vesicle-mediated transport
is_a: GO:1902582 ! single-organism intracellular transport

[Term]
id: GO:0048194
name: Golgi vesicle budding
namespace: biological_process
def: "The evagination of the Golgi membrane, resulting in formation of a vesicle." [GOC:jid, ISBN:0716731363, PMID:10219233]
synonym: "dictyosome vesicle budding" NARROW []
synonym: "Golgi-derived vesicle budding" EXACT []
is_a: GO:1902591 ! single-organism membrane budding
relationship: occurs_in GO:0000139 ! Golgi membrane
relationship: part_of GO:0048193 ! Golgi vesicle transport

[Term]
id: GO:0048195
name: Golgi membrane priming complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a membrane priming complex. An incoming coat component recognizes both GTPase and a membrane protein to form the priming complex." [GOC:jid, ISBN:0716731363, PMID:10219233]
synonym: "formation of dictyosome membrane priming complex" NARROW []
synonym: "formation of Golgi membrane priming complex" EXACT []
is_a: GO:0043623 ! cellular protein complex assembly
relationship: part_of GO:0048200 ! Golgi transport vesicle coating

[Term]
id: GO:0048196
name: obsolete plant extracellular matrix
namespace: cellular_component
def: "The matrix external to the plant plasma membrane, composed of the cell wall and middle lamella." [GOC:jid, GOC:mtg_sensu, PMID:11351084, PMID:4327466]
comment: Note that this term does not have 'extracellular region ; GO:0005576' as a parent because in plants the extracellular matrix is considered part of the cell.
subset: goslim_pir
synonym: "middle lamella-containing extracellular matrix" RELATED [GOC:tb]
synonym: "plant extracellular matrix" EXACT []
is_obsolete: true

[Term]
id: GO:0048197
name: Golgi membrane coat protein complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of priming complexes to form a coat on a Golgi membrane. Priming complexes associate laterally and additional coat proteins are recruited from the cytosol to the forming coat. Cargo proteins diffuse into the budding site and become trapped by their interactions with the coat." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233]
synonym: "dictyosome membrane binding by cytosolic coat proteins" NARROW []
synonym: "dictyosome membrane bud coat oligomerisation" NARROW []
synonym: "Golgi membrane bud coat oligomerisation" NARROW []
is_a: GO:0043623 ! cellular protein complex assembly
relationship: part_of GO:0048200 ! Golgi transport vesicle coating

[Term]
id: GO:0048198
name: Golgi vesicle bud deformation and release
namespace: biological_process
def: "The process in which cytosolic coat proteins fit together in a basketlike convex framework to form a coated deformed region on the cytoplasmic surface of the membrane. The deformed region forms into a complete vesicle and is released." [GOC:jid, ISBN:0716731363, PMID:10219233]
synonym: "dictyosome vesicle bud deformation" NARROW []
synonym: "Golgi-derived vesicle bud deformation and release" EXACT []
is_a: GO:0044802 ! single-organism membrane organization
relationship: part_of GO:0048194 ! Golgi vesicle budding

[Term]
id: GO:0048199
name: vesicle targeting, to, from or within Golgi
namespace: biological_process
def: "The process in which vesicles are directed to specific destination membranes during transport to, from or within the Golgi apparatus; mediated by the addition of specific coat proteins, including COPI and COPII proteins and clathrin, to the membrane during vesicle formation." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233]
synonym: "dictyosome vesicle targeting" NARROW []
synonym: "Golgi vesicle targeting" EXACT []
synonym: "vesicle targeting, to, from or within dictyosome" NARROW []
is_a: GO:0006903 ! vesicle targeting
relationship: part_of GO:0048193 ! Golgi vesicle transport

[Term]
id: GO:0048200
name: Golgi transport vesicle coating
namespace: biological_process
def: "The addition of specific coat proteins to Golgi membranes during the formation of transport vesicles." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233]
synonym: "dictyosome transport vesicle coating" NARROW []
is_a: GO:0006901 ! vesicle coating
relationship: part_of GO:0048194 ! Golgi vesicle budding
relationship: part_of GO:0048199 ! vesicle targeting, to, from or within Golgi

[Term]
id: GO:0048201
name: vesicle targeting, plasma membrane to endosome
namespace: biological_process
def: "The process in which vesicles formed at the plasma membrane are directed to specific destinations in endosome membranes, mediated by molecules at the vesicle membrane and target membrane surfaces." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233]
synonym: "plasma membrane to endosome targeting" EXACT []
is_a: GO:0006903 ! vesicle targeting

[Term]
id: GO:0048202
name: clathrin coating of Golgi vesicle
namespace: biological_process
def: "The addition of clathrin and adaptor proteins to Golgi membranes during the formation of transport vesicles, forming a vesicle coat." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233]
synonym: "clathrin coating of Golgi-derived vesicle" EXACT []
is_a: GO:0048200 ! Golgi transport vesicle coating
is_a: GO:0048268 ! clathrin coat assembly

[Term]
id: GO:0048203
name: vesicle targeting, trans-Golgi to endosome
namespace: biological_process
def: "The process in which vesicles are directed to specific destination membranes during transport from the trans-Golgi to the endosome." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233]
synonym: "trans-Golgi to endosome targeting" EXACT []
is_a: GO:0048199 ! vesicle targeting, to, from or within Golgi
relationship: part_of GO:0006895 ! Golgi to endosome transport

[Term]
id: GO:0048204
name: vesicle targeting, inter-Golgi cisterna
namespace: biological_process
def: "The process in which vesicles are directed to specific destination membranes during transport from one Golgi cisterna to another." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233]
synonym: "inter-Golgi cisterna targeting" EXACT []
is_a: GO:0048199 ! vesicle targeting, to, from or within Golgi
relationship: part_of GO:0048219 ! inter-Golgi cisterna vesicle-mediated transport

[Term]
id: GO:0048205
name: COPI coating of Golgi vesicle
namespace: biological_process
def: "The addition of COPI proteins and adaptor proteins to Golgi membranes during the formation of transport vesicles, forming a vesicle coat." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233]
synonym: "COPI coating of Golgi-derived vesicle" EXACT []
synonym: "COPI vesicle coating" RELATED [GOC:br]
xref: Reactome:REACT_100340 "COPI Mediated Transport, Canis familiaris"
xref: Reactome:REACT_104458 "COPI Mediated Transport, Sus scrofa"
xref: Reactome:REACT_11096 "COPI Mediated Transport, Homo sapiens"
xref: Reactome:REACT_28932 "COPI Mediated Transport, Oryza sativa"
xref: Reactome:REACT_31768 "COPI Mediated Transport, Taeniopygia guttata"
xref: Reactome:REACT_31968 "COPI Mediated Transport, Danio rerio"
xref: Reactome:REACT_33101 "COPI Mediated Transport, Saccharomyces cerevisiae"
xref: Reactome:REACT_34581 "COPI Mediated Transport, Schizosaccharomyces pombe"
xref: Reactome:REACT_76996 "COPI Mediated Transport, Plasmodium falciparum"
xref: Reactome:REACT_78003 "COPI Mediated Transport, Rattus norvegicus"
xref: Reactome:REACT_78191 "COPI Mediated Transport, Bos taurus"
xref: Reactome:REACT_82601 "COPI Mediated Transport, Drosophila melanogaster"
xref: Reactome:REACT_85460 "COPI Mediated Transport, Arabidopsis thaliana"
xref: Reactome:REACT_86118 "COPI Mediated Transport, Gallus gallus"
xref: Reactome:REACT_92281 "COPI Mediated Transport, Dictyostelium discoideum"
xref: Reactome:REACT_94052 "COPI Mediated Transport, Xenopus tropicalis"
xref: Reactome:REACT_95898 "COPI Mediated Transport, Mus musculus"
xref: Reactome:REACT_97338 "COPI Mediated Transport, Caenorhabditis elegans"
is_a: GO:0048200 ! Golgi transport vesicle coating
relationship: part_of GO:0035964 ! COPI-coated vesicle budding

[Term]
id: GO:0048206
name: vesicle targeting, cis-Golgi to rough ER
namespace: biological_process
def: "The process in which vesicles are directed to specific destination membranes during transport from the cis-Golgi to the rough ER." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233]
synonym: "cis-Golgi to rough endoplasmic reticulum targeting" EXACT []
synonym: "cis-Golgi to rough ER targeting" EXACT []
synonym: "vesicle targeting, cis-Golgi to rough endoplasmic reticulum" EXACT []
is_a: GO:0006890 ! retrograde vesicle-mediated transport, Golgi to ER
is_a: GO:0048199 ! vesicle targeting, to, from or within Golgi
is_a: GO:0051650 ! establishment of vesicle localization
is_a: GO:1902580 ! single-organism cellular localization

[Term]
id: GO:0048207
name: vesicle targeting, rough ER to cis-Golgi
namespace: biological_process
def: "The process in which vesicles are directed to specific destination membranes during transport from the rough endoplasmic reticulum to the cis-Golgi." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233]
synonym: "rough endoplasmic reticulum to cis-Golgi targeting" EXACT []
synonym: "rough ER to cis-Golgi targeting" EXACT []
synonym: "vesicle targeting, rough endoplasmic reticulum to cis-Golgi" EXACT []
is_a: GO:0048199 ! vesicle targeting, to, from or within Golgi
relationship: part_of GO:0006888 ! ER to Golgi vesicle-mediated transport

[Term]
id: GO:0048208
name: COPII vesicle coating
namespace: biological_process
def: "The addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat." [GOC:ascb_2009, GOC:dph, GOC:jid, GOC:mah, GOC:tb, ISBN:0716731363, PMID:10219233]
synonym: "COPII coating of ER-derived vesicle" EXACT [GOC:tb]
synonym: "COPII vesicle coat assembly" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "COPII vesicle coat formation" EXACT [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb]
xref: Reactome:REACT_104367 "COPII (Coat Protein 2) Mediated Vesicle Transport, Gallus gallus"
xref: Reactome:REACT_105888 "COPII (Coat Protein 2) Mediated Vesicle Transport, Saccharomyces cerevisiae"
xref: Reactome:REACT_110782 "COPII (Coat Protein 2) Mediated Vesicle Transport, Sus scrofa"
xref: Reactome:REACT_110946 "COPII (Coat Protein 2) Mediated Vesicle Transport, Oryza sativa"
xref: Reactome:REACT_12507 "COPII (Coat Protein 2) Mediated Vesicle Transport, Homo sapiens"
xref: Reactome:REACT_29439 "COPII (Coat Protein 2) Mediated Vesicle Transport, Taeniopygia guttata"
xref: Reactome:REACT_77017 "COPII (Coat Protein 2) Mediated Vesicle Transport, Arabidopsis thaliana"
xref: Reactome:REACT_77075 "COPII (Coat Protein 2) Mediated Vesicle Transport, Danio rerio"
xref: Reactome:REACT_78619 "COPII (Coat Protein 2) Mediated Vesicle Transport, Bos taurus"
xref: Reactome:REACT_82700 "COPII (Coat Protein 2) Mediated Vesicle Transport, Mus musculus"
xref: Reactome:REACT_83562 "COPII (Coat Protein 2) Mediated Vesicle Transport, Plasmodium falciparum"
xref: Reactome:REACT_88864 "COPII (Coat Protein 2) Mediated Vesicle Transport, Xenopus tropicalis"
xref: Reactome:REACT_89635 "COPII (Coat Protein 2) Mediated Vesicle Transport, Drosophila melanogaster"
xref: Reactome:REACT_89847 "COPII (Coat Protein 2) Mediated Vesicle Transport, Dictyostelium discoideum"
xref: Reactome:REACT_95605 "COPII (Coat Protein 2) Mediated Vesicle Transport, Rattus norvegicus"
xref: Reactome:REACT_97446 "COPII (Coat Protein 2) Mediated Vesicle Transport, Schizosaccharomyces pombe"
xref: Reactome:REACT_99504 "COPII (Coat Protein 2) Mediated Vesicle Transport, Canis familiaris"
is_a: GO:0006461 ! protein complex assembly
is_a: GO:0006901 ! vesicle coating
relationship: part_of GO:0048207 ! vesicle targeting, rough ER to cis-Golgi
relationship: part_of GO:0090114 ! COPII-coated vesicle budding

[Term]
id: GO:0048209
name: regulation of vesicle targeting, to, from or within Golgi
namespace: biological_process
def: "Any process that modulates the frequency, rate, or destination of vesicle-mediated transport to, from or within the Golgi apparatus." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233]
synonym: "regulation of Golgi vesicle targeting" EXACT []
is_a: GO:0032386 ! regulation of intracellular transport
is_a: GO:0060627 ! regulation of vesicle-mediated transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048199 ! vesicle targeting, to, from or within Golgi
relationship: regulates GO:0048199 ! vesicle targeting, to, from or within Golgi

[Term]
id: GO:0048210
name: Golgi vesicle fusion to target membrane
namespace: biological_process
def: "The joining of the lipid bilayer membrane around a Golgi transport vesicle to the target lipid bilayer membrane." [GOC:jid, ISBN:0716731363, PMID:10219233]
synonym: "dictyosome vesicle fusion to target membrane" NARROW []
synonym: "Golgi-derived vesicle fusion to target membrane" EXACT []
is_a: GO:0006906 ! vesicle fusion
relationship: part_of GO:0048193 ! Golgi vesicle transport

[Term]
id: GO:0048211
name: Golgi vesicle docking
namespace: biological_process
def: "The initial attachment of a Golgi transport vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the Golgi vesicle and the target membrane." [GOC:jid, ISBN:0716731363, PMID:10219233]
synonym: "dictyosome vesicle docking to target membrane" NARROW []
synonym: "Golgi vesicle docking with target membrane" EXACT []
synonym: "Golgi vesicle to membrane docking" EXACT []
synonym: "Golgi-derived vesicle docking" EXACT []
is_a: GO:0048278 ! vesicle docking
relationship: part_of GO:0048193 ! Golgi vesicle transport

[Term]
id: GO:0048212
name: Golgi vesicle uncoating
namespace: biological_process
def: "The process in which Golgi vesicle coat proteins are depolymerized, and released for reuse." [GOC:jid, ISBN:0716731363, PMID:10219233]
synonym: "dictyosome vesicle coat depolymerization" NARROW []
synonym: "Golgi vesicle coat depolymerization" EXACT []
synonym: "Golgi vesicle coat protein depolymerization" EXACT []
synonym: "Golgi-derived vesicle uncoating" EXACT []
is_a: GO:0072319 ! vesicle uncoating
relationship: part_of GO:0048193 ! Golgi vesicle transport

[Term]
id: GO:0048213
name: Golgi vesicle prefusion complex stabilization
namespace: biological_process
def: "The binding of specific proteins to the t-SNARE/v-SNARE/SNAP25 complex, by which the Golgi vesicle prefusion complex is stabilized." [GOC:jid, ISBN:0716731363, PMID:10219233]
synonym: "dictyosome vesicle prefusion complex stabilisation" NARROW []
synonym: "Golgi vesicle prefusion complex assembly" EXACT []
synonym: "Golgi-derived vesicle prefusion complex stabilization" EXACT []
is_a: GO:0043623 ! cellular protein complex assembly
relationship: part_of GO:0048193 ! Golgi vesicle transport

[Term]
id: GO:0048214
name: regulation of Golgi vesicle fusion to target membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Golgi vesicle fusion to target membrane." [GOC:jid, ISBN:0716731363, PMID:10219233]
comment: Note that GTP-binding Rab proteins serve as regulators of vesicle targeting and fusion.
is_a: GO:0031338 ! regulation of vesicle fusion
is_a: GO:0032386 ! regulation of intracellular transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048210 ! Golgi vesicle fusion to target membrane
relationship: regulates GO:0048210 ! Golgi vesicle fusion to target membrane

[Term]
id: GO:0048215
name: positive regulation of Golgi vesicle fusion to target membrane
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of Golgi vesicle fusion to target membrane." [GOC:jid, ISBN:0716731363, PMID:10219233]
synonym: "activation of Golgi vesicle fusion to target membrane" NARROW []
synonym: "stimulation of Golgi vesicle fusion to target membrane" NARROW []
synonym: "up regulation of Golgi vesicle fusion to target membrane" EXACT []
synonym: "up-regulation of Golgi vesicle fusion to target membrane" EXACT []
synonym: "upregulation of Golgi vesicle fusion to target membrane" EXACT []
is_a: GO:0031340 ! positive regulation of vesicle fusion
is_a: GO:0032388 ! positive regulation of intracellular transport
is_a: GO:0048214 ! regulation of Golgi vesicle fusion to target membrane
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048210 ! Golgi vesicle fusion to target membrane
relationship: positively_regulates GO:0048210 ! Golgi vesicle fusion to target membrane

[Term]
id: GO:0048216
name: negative regulation of Golgi vesicle fusion to target membrane
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Golgi vesicle fusion to target membrane." [GOC:jid, ISBN:0716731363, PMID:10219233]
synonym: "down regulation of Golgi vesicle fusion to target membrane" EXACT []
synonym: "down-regulation of Golgi vesicle fusion to target membrane" EXACT []
synonym: "downregulation of Golgi vesicle fusion to target membrane" EXACT []
synonym: "inhibition of Golgi vesicle fusion to target membrane" NARROW []
is_a: GO:0031339 ! negative regulation of vesicle fusion
is_a: GO:0032387 ! negative regulation of intracellular transport
is_a: GO:0048214 ! regulation of Golgi vesicle fusion to target membrane
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048210 ! Golgi vesicle fusion to target membrane
relationship: negatively_regulates GO:0048210 ! Golgi vesicle fusion to target membrane

[Term]
id: GO:0048217
name: pectic matrix
namespace: cellular_component
def: "The gel-like pectin matrix consists of the interlinked acidic and neutral pectin networks that are further cross-linked by calcium bridges. Pectins consist largely of long chains of mostly galacturonic acid units (typically 1,4 linkages and sometimes methyl esters). Three major pectic polysaccharides (homogalacturonan, rhamnogalacturonan I and rhamnogalacturonan II) are thought to occur in all primary cell walls." [GOC:jid, PMID:11554482]
is_a: GO:0044426 ! cell wall part
relationship: part_of GO:0009530 ! primary cell wall
relationship: part_of GO:0009531 ! secondary cell wall

[Term]
id: GO:0048219
name: inter-Golgi cisterna vesicle-mediated transport
namespace: biological_process
def: "The directed movement of substances from one Golgi cisterna to another, mediated by small transport vesicles." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233]
synonym: "inter-Golgi cisterna transport" EXACT []
is_a: GO:0006891 ! intra-Golgi vesicle-mediated transport

[Term]
id: GO:0048222
name: glycoprotein network
namespace: cellular_component
def: "An extracellular matrix part that consists of cross-linked glycoproteins." [GOC:mah, PMID:18508691, PMID:7048321]
synonym: "extensin" EXACT []
xref: Wikipedia:Extensin
is_a: GO:0044426 ! cell wall part
relationship: part_of GO:0009530 ! primary cell wall

[Term]
id: GO:0048223
name: hemicellulose network
namespace: cellular_component
def: "Network composed of hemicelluloses; members of a class of plant cell wall polysaccharide that cannot be extracted from the wall by hot water or chelating agents, but can be extracted by aqueous alkali. Includes xylan, glucuronoxylan, arabinoxylan, arabinogalactan II, glucomannan, xyloglucan and galactomannan." [DOI:10.1016/j.foodchem.2008.11.065, GOC:jid]
is_a: GO:0044426 ! cell wall part
relationship: part_of GO:0009530 ! primary cell wall
relationship: part_of GO:0009531 ! secondary cell wall

[Term]
id: GO:0048224
name: lignin network
namespace: cellular_component
def: "An extracellular matrix part that consists of lignin in the form of a three-dimensional polymeric network. Lignins are complex racemic aromatic heteropolymers derived from a variety of phenylpropane monomers coupled together by an assortment of carbon-carbon and ether linkages. Lignin is crucial for structural integrity of the cell wall and stiffness and strength of the stem. In addition, lignin waterproofs the cell wall, enabling transport of water and solutes through the vascular system, and plays a role in protecting plants against pathogens." [GOC:jid, GOC:mah, PMID:14503002, PMID:16662709]
is_a: GO:0044426 ! cell wall part
relationship: part_of GO:0009531 ! secondary cell wall

[Term]
id: GO:0048225
name: suberin network
namespace: cellular_component
def: "An extracellular matrix part that consists of fatty acid-derived polymers, including both aromatic and aliphatic components. The suberin network is found in specialized plant cell walls, where it is laid down between the primary wall and plasma membrane, forms protective and wound-healing layers, and provides a water-impermeable diffusion barrier." [GOC:jid, GOC:mah, PMID:18440267, PMID:7706282]
is_a: GO:0044426 ! cell wall part
relationship: part_of GO:0009531 ! secondary cell wall

[Term]
id: GO:0048226
name: Casparian strip
namespace: cellular_component
def: "Region of plant cell wall specialised to act as a seal to prevent back leakage of secreted material (analogous to tight junction between epithelial cells). Found particularly where root parenchymal cells secrete solutes into xylem vessels. The barrier is composed of suberin; a fatty substance, containing long chain fatty acids and fatty esters, also found in the cell walls of cork cells (phellem) in higher plants." [GOC:jid]
xref: Wikipedia:Casparian_strip
is_a: GO:0044426 ! cell wall part
relationship: part_of GO:0009531 ! secondary cell wall

[Term]
id: GO:0048227
name: plasma membrane to endosome transport
namespace: biological_process
def: "Transport of a vesicle from the plasma membrane to the endosome." [GOC:jid]
is_a: GO:0016192 ! vesicle-mediated transport
is_a: GO:0016197 ! endosomal transport

[Term]
id: GO:0048228
name: obsolete actin cortical patch distribution
namespace: biological_process
def: "OBSOLETE. Any process that establishes the spatial arrangement of actin cortical patches. An actin cortical patch is a discrete actin-containing structure found at the plasma membrane in fungal cells." [GOC:jid]
comment: This term was made obsolete because its definition is very similar to that of its parent term, actin cortical patch localization (GO:0051666), but somewhat unclear, and not similar enough to merge the terms.
synonym: "actin cortical patch distribution" EXACT []
is_obsolete: true

[Term]
id: GO:0048229
name: gametophyte development
namespace: biological_process
def: "The process whose specific outcome is the progression of the gametophyte over time, from its formation to the mature structure. The gametophyte is the gamete-producing individual or phase in the life cycle having alternation of generations. An example of this process is found in Arabidopsis thaliana." [GOC:jid, PO:0009004]
synonym: "gametogenesis" BROAD []
is_a: GO:0007275 ! multicellular organism development

[Term]
id: GO:0048232
name: male gamete generation
namespace: biological_process
def: "Generation of the male gamete; specialised haploid cells produced by meiosis and along with a female gamete takes part in sexual reproduction." [GOC:dph, GOC:jid]
is_a: GO:0007276 ! gamete generation

[Term]
id: GO:0048235
name: pollen sperm cell differentiation
namespace: biological_process
alt_id: GO:0048234
def: "The process in which a relatively unspecialized cell acquires specialized features of a haploid sperm cell within the plant gametophyte." [CL:0000366, GOC:jid, GOC:mtg_sensu]
synonym: "male gamete generation" BROAD []
synonym: "male gametophyte sperm cell differentiation" EXACT []
synonym: "sperm cell differentiation" BROAD []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0048232 ! male gamete generation
relationship: part_of GO:0055046 ! microgametogenesis

[Term]
id: GO:0048236
name: plant-type spore development
namespace: biological_process
def: "The process whose specific outcome is the progression of the spore over time, from its formation to the mature structure. The spore gives rise to gametophytes." [GOC:jid, http://www.m-w.com]
synonym: "plant spore development" EXACT []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048856 ! anatomical structure development
is_a: GO:0048869 ! cellular developmental process
is_a: GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0048237
name: rough endoplasmic reticulum lumen
namespace: cellular_component
def: "The volume enclosed by the membranes of the rough endoplasmic reticulum." [GOC:jid]
synonym: "RER lumen" EXACT []
synonym: "rough ER lumen" EXACT []
xref: NIF_Subcellular:sao1819509473
is_a: GO:0005788 ! endoplasmic reticulum lumen
relationship: part_of GO:0005791 ! rough endoplasmic reticulum

[Term]
id: GO:0048238
name: smooth endoplasmic reticulum lumen
namespace: cellular_component
def: "The volume enclosed by the membranes of the smooth endoplasmic reticulum." [GOC:jid]
synonym: "SER lumen" EXACT []
synonym: "smooth ER lumen" EXACT []
xref: NIF_Subcellular:sao927884761
is_a: GO:0005788 ! endoplasmic reticulum lumen
is_a: GO:0097425 ! smooth endoplasmic reticulum part
relationship: part_of GO:0005790 ! smooth endoplasmic reticulum

[Term]
id: GO:0048239
name: negative regulation of DNA recombination at telomere
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of genetic recombination within the telomere." [GOC:jid, PMID:9635193]
synonym: "down regulation of telomeric recombination at telomere" EXACT []
synonym: "down-regulation of telomeric recombination at telomere" EXACT []
synonym: "downregulation of telomeric recombination at telomere" EXACT []
synonym: "inhibition of telomeric recombination at telomere" NARROW []
synonym: "negative regulation of telomeric recombination at telomere" EXACT [GOC:tb]
synonym: "suppression of telomeric recombination at telomere" EXACT []
is_a: GO:0045910 ! negative regulation of DNA recombination
is_a: GO:0072695 ! regulation of DNA recombination at telomere

[Term]
id: GO:0048240
name: sperm capacitation
namespace: biological_process
def: "A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium." [GOC:jid, PMID:11820818]
synonym: "sperm activation" RELATED [PMID:23180860]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0048469 ! cell maturation
relationship: part_of GO:0007286 ! spermatid development

[Term]
id: GO:0048241
name: epinephrine transport
namespace: biological_process
def: "The directed movement of epinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jid]
synonym: "adrenaline transport" EXACT []
is_a: GO:0009914 ! hormone transport
is_a: GO:0051937 ! catecholamine transport

[Term]
id: GO:0048242
name: epinephrine secretion
namespace: biological_process
def: "The regulated release of epinephrine by a cell. Epinephrine is a catecholamine hormone secreted by the adrenal medulla and a neurotransmitter, released by certain neurons and active in the central nervous system." [GOC:ef, GOC:jid]
synonym: "adrenaline secretion" EXACT []
is_a: GO:0046879 ! hormone secretion
is_a: GO:0048241 ! epinephrine transport
is_a: GO:0050432 ! catecholamine secretion

[Term]
id: GO:0048243
name: norepinephrine secretion
namespace: biological_process
def: "The regulated release of norepinephrine by a cell. Norepinephrine is a catecholamine and it acts as a hormone and as a neurotransmitter of most of the sympathetic nervous system." [GOC:ef, GOC:jid]
synonym: "noradrenaline secretion" EXACT []
is_a: GO:0015874 ! norepinephrine transport
is_a: GO:0050432 ! catecholamine secretion

[Term]
id: GO:0048244
name: phytanoyl-CoA dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + O(2) + phytanoyl-CoA = 2-hydroxyphytanoyl-CoA + CO(2) + succinate." [EC:1.14.11.18, RHEA:16068]
synonym: "phytanoyl-CoA 2 oxoglutarate dioxygenase activity" EXACT [EC:1.14.11.18]
synonym: "phytanoyl-CoA 2-hydroxylase activity" EXACT [EC:1.14.11.18]
synonym: "phytanoyl-CoA alpha-hydroxylase activity" EXACT [EC:1.14.11.18]
synonym: "phytanoyl-CoA hydroxylase activity" EXACT [EC:1.14.11.18]
synonym: "phytanoyl-CoA, 2-oxoglutarate:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.11.18]
xref: EC:1.14.11.18
xref: KEGG:R05722
xref: MetaCyc:1.14.11.18-RXN
xref: Reactome:REACT_100986 "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2, Xenopus tropicalis"
xref: Reactome:REACT_103708 "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2, Canis familiaris"
xref: Reactome:REACT_17021 "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2, Homo sapiens"
xref: Reactome:REACT_28909 "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2, Taeniopygia guttata"
xref: Reactome:REACT_33181 "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2, Bos taurus"
xref: Reactome:REACT_34659 "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2, Danio rerio"
xref: Reactome:REACT_76940 "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2, Mus musculus"
xref: Reactome:REACT_79033 "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2, Rattus norvegicus"
xref: Reactome:REACT_81723 "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2, Gallus gallus"
xref: Reactome:REACT_88317 "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2, Caenorhabditis elegans"
xref: RHEA:16068
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0048245
name: eosinophil chemotaxis
namespace: biological_process
def: "The movement of an eosinophil in response to an external stimulus." [GOC:jid, PMID:11292027, PMID:12391252]
is_a: GO:0071621 ! granulocyte chemotaxis
is_a: GO:0072677 ! eosinophil migration

[Term]
id: GO:0048246
name: macrophage chemotaxis
namespace: biological_process
def: "The movement of a macrophage in response to an external stimulus." [GOC:jid]
is_a: GO:0030595 ! leukocyte chemotaxis
is_a: GO:0097529 ! myeloid leukocyte migration

[Term]
id: GO:0048247
name: lymphocyte chemotaxis
namespace: biological_process
def: "The directed movement of a lymphocyte in response to an external stimulus." [GOC:hjd, GOC:jid, PMID:12391252]
is_a: GO:0030595 ! leukocyte chemotaxis
is_a: GO:0072676 ! lymphocyte migration

[Term]
id: GO:0048248
name: CXCR3 chemokine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a the CXCR3 chemokine receptor." [GOC:jid, PMID:10556837]
is_a: GO:0045236 ! CXCR chemokine receptor binding

[Term]
id: GO:0048249
name: high-affinity phosphate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of phosphate from one side of the membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:jid, PMID:8709965]
synonym: "high affinity phosphate transmembrane transporter activity" EXACT []
is_a: GO:0015114 ! phosphate ion transmembrane transporter activity

[Term]
id: GO:0048250
name: mitochondrial iron ion transport
namespace: biological_process
def: "The directed movement of iron ions into, out of or within a mitochondrion." [GOC:jid, PMID:12006577]
synonym: "mitochondrial iron transport" EXACT []
is_a: GO:0006826 ! iron ion transport
is_a: GO:0006839 ! mitochondrial transport

[Term]
id: GO:0048251
name: elastic fiber assembly
namespace: biological_process
def: "Assembly of the extracellular matrix fibers that enables the matrix to recoil after transient stretching." [GOC:jid, PMID:10841810, PMID:12615674]
synonym: "elastic fibre assembly" EXACT []
synonym: "elastin fiber assembly" EXACT [GOC:BHF]
synonym: "elastin fibre assembly" EXACT [GOC:BHF]
is_a: GO:0085029 ! extracellular matrix assembly

[Term]
id: GO:0048252
name: lauric acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lauric acid, a fatty acid with the formula CH3(CH2)10COOH. Derived from vegetable sources." [CHEBI:30805, GOC:jid]
subset: gosubset_prok
synonym: "lauric acid metabolism" EXACT []
synonym: "n-dodecanoic acid metabolic process" EXACT []
synonym: "n-dodecanoic acid metabolism" EXACT []
is_a: GO:0051791 ! medium-chain fatty acid metabolic process

[Term]
id: GO:0048254
name: snoRNA localization
namespace: biological_process
def: "Any process in which small nucleolar RNA is transported to, or maintained in, a specific location." [ISBN:0716731363]
synonym: "establishment and maintenance of snoRNA localization" EXACT []
synonym: "small nucleolar RNA localization" EXACT []
synonym: "snoRNA localisation" EXACT [GOC:mah]
is_a: GO:0006403 ! RNA localization

[Term]
id: GO:0048255
name: mRNA stabilization
namespace: biological_process
def: "Prevention of degradation of mRNA molecules. In the absence of compensating changes in other processes, the slowing of mRNA degradation can result in an overall increase in the population of active mRNA molecules." [GOC:jid]
subset: gosubset_prok
is_a: GO:0043488 ! regulation of mRNA stability
is_a: GO:0043489 ! RNA stabilization

[Term]
id: GO:0048256
name: flap endonuclease activity
namespace: molecular_function
def: "Catalysis of the cleavage of a flap structure in DNA, but not other DNA structures; processes the ends of Okazaki fragments in lagging strand DNA synthesis." [GOC:jid]
subset: gosubset_prok
xref: EC:3.1.-.-.
is_a: GO:0004520 ! endodeoxyribonuclease activity

[Term]
id: GO:0048257
name: 3'-flap endonuclease activity
namespace: molecular_function
def: "Catalysis of the cleavage of a 3' flap structure in DNA, but not other DNA structures; processes the 3' ends of Okazaki fragments in lagging strand DNA synthesis." [GOC:jid, PMID:10635319]
synonym: "3' flap endonuclease activity" EXACT []
is_a: GO:0016889 ! endodeoxyribonuclease activity, producing 3'-phosphomonoesters
is_a: GO:0048256 ! flap endonuclease activity

[Term]
id: GO:0048258
name: 3-ketoglucose-reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + 3-dehydro-alpha-D-glucose = NADPH + alpha-D-glucose." [MetaCyc:KETOGLUCOSE-REDUCTASE-RXN]
xref: EC:1.1.1.-
xref: MetaCyc:KETOGLUCOSE-REDUCTASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0048259
name: regulation of receptor-mediated endocytosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport." [GOC:go_curators, GOC:tb]
synonym: "regulation of receptor mediated endocytosis" EXACT [GOC:tb]
is_a: GO:0030100 ! regulation of endocytosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006898 ! receptor-mediated endocytosis
relationship: regulates GO:0006898 ! receptor-mediated endocytosis

[Term]
id: GO:0048260
name: positive regulation of receptor-mediated endocytosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport." [GOC:go_curators, GOC:tb]
synonym: "activation of receptor mediated endocytosis" NARROW []
synonym: "positive regulation of receptor mediated endocytosis" EXACT [GOC:tb]
synonym: "stimulation of receptor mediated endocytosis" NARROW []
synonym: "up regulation of receptor mediated endocytosis" EXACT []
synonym: "up-regulation of receptor mediated endocytosis" EXACT []
synonym: "upregulation of receptor mediated endocytosis" EXACT []
is_a: GO:0045807 ! positive regulation of endocytosis
is_a: GO:0048259 ! regulation of receptor-mediated endocytosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006898 ! receptor-mediated endocytosis
relationship: positively_regulates GO:0006898 ! receptor-mediated endocytosis

[Term]
id: GO:0048261
name: negative regulation of receptor-mediated endocytosis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport." [GOC:go_curators]
synonym: "down regulation of receptor mediated endocytosis" EXACT []
synonym: "down-regulation of receptor mediated endocytosis" EXACT []
synonym: "downregulation of receptor mediated endocytosis" EXACT []
synonym: "inhibition of receptor mediated endocytosis" NARROW []
synonym: "negative regulation of receptor mediated endocytosis" EXACT []
is_a: GO:0045806 ! negative regulation of endocytosis
is_a: GO:0048259 ! regulation of receptor-mediated endocytosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006898 ! receptor-mediated endocytosis
relationship: negatively_regulates GO:0006898 ! receptor-mediated endocytosis

[Term]
id: GO:0048262
name: determination of dorsal/ventral asymmetry
namespace: biological_process
def: "Determination of asymmetry from the dorsal to the ventral side; as, the dorsoventral axis." [GOC:jid]
synonym: "determination of adaxial/abaxial asymmetry" RELATED [GOC:dph, GOC:tb]
synonym: "determination of dorsal-ventral asymmetry" EXACT [GOC:mah]
synonym: "determination of dorsoventral asymmetry" EXACT [GOC:mah]
is_a: GO:0009855 ! determination of bilateral symmetry
relationship: part_of GO:0009953 ! dorsal/ventral pattern formation

[Term]
id: GO:0048263
name: determination of dorsal identity
namespace: biological_process
def: "Determination of the identity of part of an organism or organ where those parts are of the type that occur in the dorsal region. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:jid]
synonym: "determination of adaxial identity" RELATED [GOC:dph, GOC:tb]
is_a: GO:0009953 ! dorsal/ventral pattern formation
relationship: part_of GO:0048262 ! determination of dorsal/ventral asymmetry

[Term]
id: GO:0048264
name: determination of ventral identity
namespace: biological_process
def: "The regionalization process that results in the determination of the identity of part of an organism or organ where those parts are of the type that occur in the ventral region. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:dph, GOC:isa_complete, GOC:jid]
synonym: "determination of abaxial identity" EXACT []
is_a: GO:0009953 ! dorsal/ventral pattern formation
relationship: part_of GO:0048262 ! determination of dorsal/ventral asymmetry

[Term]
id: GO:0048265
name: response to pain
namespace: biological_process
alt_id: GO:0048267
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli." [GOC:jid, PMID:10203867, PMID:12723742, PMID:12843304, Wikipedia:Pain]
synonym: "physiological response to pain" EXACT []
is_a: GO:0033555 ! multicellular organismal response to stress

[Term]
id: GO:0048266
name: behavioral response to pain
namespace: biological_process
def: "Any process that results in a change in the behavior of an organism as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli." [GOC:jid]
synonym: "behavioural response to pain" EXACT []
is_a: GO:0044708 ! single-organism behavior
relationship: part_of GO:0048265 ! response to pain

[Term]
id: GO:0048268
name: clathrin coat assembly
namespace: biological_process
def: "The process that results in the assembly of clathrin triskelia into the ordered structure known as a clathrin cage." [GOC:jid, PMID:11460887, PMID:11977118, PMID:9531549]
synonym: "clathrin cage assembly" EXACT []
is_a: GO:0006901 ! vesicle coating
is_a: GO:0043623 ! cellular protein complex assembly

[Term]
id: GO:0048269
name: methionine adenosyltransferase complex
namespace: cellular_component
def: "A multimeric enzyme complex composed of variable numbers of catalytic alpha subunits, and noncatalytic beta subunits. The beta subunits are believed to have a regulatory function. The enzyme complex catalyzes the synthesis of S-adenosylmethionine (AdoMet), which is the major methyl group donor, participating in the methylation of proteins, DNA, RNA, phospholipids, and other small molecules." [EC:2.5.1.6, GOC:jid, PMID:10644686]
synonym: "MAT complex" EXACT []
is_a: GO:0044424 ! intracellular part
is_a: GO:1990234 ! transferase complex

[Term]
id: GO:0048270
name: methionine adenosyltransferase regulator activity
namespace: molecular_function
def: "Modulates the activity of methionine adenosyltransferase." [EC:2.5.1.6, GOC:jid, PMID:10644686]
comment: See also the molecular function term 'methionine adenosyltransferase activity ; GO:0004478'.
synonym: "MAT regulator activity" EXACT []
is_a: GO:0030234 ! enzyme regulator activity
relationship: regulates GO:0004478 ! methionine adenosyltransferase activity

[Term]
id: GO:0048273
name: mitogen-activated protein kinase p38 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with mitogen-activated protein kinase p38, an enzyme that catalyzes the transfer of phosphate from ATP to hydroxyl side chains on proteins in response to mitogen activation." [GOC:curators, PMID:17827184]
synonym: "MAPK p38 binding" EXACT []
is_a: GO:0051019 ! mitogen-activated protein kinase binding

[Term]
id: GO:0048275
name: N-terminal peptidyl-arginine acetylation
namespace: biological_process
def: "The acetylation of the N-terminal arginine of proteins; catalyzed by an uncharacterized arginyl-peptide alpha-N-acetyltransferase." [GOC:jsg, PMID:12883043, RESID:AA0354]
subset: gosubset_prok
xref: RESID:AA0354
is_a: GO:0006474 ! N-terminal protein amino acid acetylation
is_a: GO:0018195 ! peptidyl-arginine modification

[Term]
id: GO:0048277
name: obsolete nonexocytotic vesicle docking
namespace: biological_process
def: "OBSOLETE. The initial attachment of a transport vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, during a non-exocytotic process." [GOC:jid]
comment: This term was made obsolete because it violates the principle of positivity.
synonym: "non-exocytotic vesicle docking" EXACT []
synonym: "nonexocytotic vesicle docking" EXACT []
is_obsolete: true
replaced_by: GO:0048278

[Term]
id: GO:0048278
name: vesicle docking
namespace: biological_process
def: "The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere." [GOC:ai, GOC:jid]
subset: gosubset_prok
synonym: "vesicle to membrane docking" EXACT []
is_a: GO:0022406 ! membrane docking
relationship: part_of GO:0016192 ! vesicle-mediated transport

[Term]
id: GO:0048279
name: vesicle fusion with endoplasmic reticulum
namespace: biological_process
def: "The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the endoplasmic reticulum." [GOC:jid]
synonym: "vesicle fusion with ER" EXACT []
is_a: GO:0006906 ! vesicle fusion

[Term]
id: GO:0048280
name: vesicle fusion with Golgi apparatus
namespace: biological_process
def: "The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi." [GOC:jid]
is_a: GO:0006906 ! vesicle fusion
relationship: part_of GO:0048193 ! Golgi vesicle transport

[Term]
id: GO:0048281
name: inflorescence morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of inflorescences are generated and organized. An inflorescence is the part of a seed plant body that is usually above ground and that can bear flowers." [GOC:jid]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0009886 ! post-embryonic morphogenesis
is_a: GO:0010016 ! shoot system morphogenesis
relationship: part_of GO:0010229 ! inflorescence development

[Term]
id: GO:0048282
name: determinate inflorescence morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of determinate inflorescences are generated and organized. A determinate inflorescence is one that can only produce a predetermined number of floral meristems." [GOC:jid, PMID:9553044]
is_a: GO:0048281 ! inflorescence morphogenesis

[Term]
id: GO:0048283
name: indeterminate inflorescence morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of determinate inflorescences are generated and organized. A determinate inflorescence is one that can produce an undefined number of floral meristems." [GOC:jid]
is_a: GO:0048281 ! inflorescence morphogenesis

[Term]
id: GO:0048284
name: organelle fusion
namespace: biological_process
def: "The creation of a single organelle from two or more organelles." [GOC:jid]
subset: goslim_pir
subset: goslim_yeast
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0048285
name: organelle fission
namespace: biological_process
def: "The creation of two or more organelles by division of one organelle." [GOC:jid]
subset: goslim_pir
subset: goslim_yeast
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0048286
name: lung alveolus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways." [GOC:mtg_lung, PMID:9751757]
synonym: "alveolarization" EXACT [PMID:17911382]
synonym: "alveologenesis" EXACT [GOC:17911382]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0030324 ! lung development

[Term]
id: GO:0048288
name: nuclear membrane fusion involved in karyogamy
namespace: biological_process
def: "The joining of 2 or more lipid bilayer membranes that surround the nucleus during the creation of a single nucleus from multiple nuclei." [GOC:jid]
synonym: "nuclear membrane fusion during karyogamy" RELATED [GOC:dph, GOC:tb]
is_a: GO:0000740 ! nuclear membrane fusion
intersection_of: GO:0000740 ! nuclear membrane fusion
intersection_of: part_of GO:0000741 ! karyogamy
relationship: part_of GO:0000741 ! karyogamy

[Term]
id: GO:0048289
name: isotype switching to IgE isotypes
namespace: biological_process
def: "The switching of activated B cells from IgM biosynthesis to IgE biosynthesis, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and IgE constant region gene segments in the immunoglobulin heavy chain locus." [ISBN:0781735149, PMID:12370374, PMID:2113175, PMID:9186655]
synonym: "class switch recombination to IgE isotypes" EXACT []
synonym: "class switching to IgE isotypes" EXACT []
synonym: "isotype switch recombination to IgE isotypes" EXACT []
is_a: GO:0045190 ! isotype switching

[Term]
id: GO:0048290
name: isotype switching to IgA isotypes
namespace: biological_process
def: "The switching of activated B cells from IgM biosynthesis to biosynthesis of an IgA isotype, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and one of the IgA constant region gene segments in the immunoglobulin heavy chain locus." [ISBN:0781735149, PMID:12370374, PMID:2113175, PMID:9186655]
synonym: "class switching to IgA isotypes" EXACT []
synonym: "isotype switch recombination to IgA isotypes" EXACT []
is_a: GO:0045190 ! isotype switching

[Term]
id: GO:0048291
name: isotype switching to IgG isotypes
namespace: biological_process
def: "The switching of activated B cells from IgM biosynthesis to biosynthesis of an IgG isotype, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and one of the IgG constant region gene segments in the immunoglobulin heavy chain locus." [ISBN:0781735149, PMID:12370374, PMID:2113175, PMID:9186655]
synonym: "class switching to IgG isotypes" EXACT []
synonym: "isotype switch recombination to IgG isotypes" EXACT []
is_a: GO:0045190 ! isotype switching

[Term]
id: GO:0048292
name: isotype switching to IgD isotypes
namespace: biological_process
def: "The switching of activated B cells from IgM biosynthesis to IgD biosynthesis, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and IgD constant region gene segments in the immunoglobulin heavy chain locus." [ISBN:0781735149, PMID:12370374, PMID:2113175, PMID:9186655]
comment: Note that this term is to be used only for gene products involved in the expression of IgD through recombinational switching into the vestigial switch region at the 5' end of the IgD gene segment, rather than gene products involved in the expression of IgD through alternative splicing mechanisms.
synonym: "class switching to IgD isotypes" EXACT []
synonym: "isotype switch recombination to IgD isotypes" EXACT []
is_a: GO:0045190 ! isotype switching

[Term]
id: GO:0048293
name: regulation of isotype switching to IgE isotypes
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of isotype switching to IgE isotypes." [GOC:jid]
synonym: "regulation of class switch recombination to IgE isotypes" EXACT []
synonym: "regulation of class switching to IgE isotypes" EXACT []
synonym: "regulation of isotype switch recombination to IgE isotypes" EXACT []
is_a: GO:0045191 ! regulation of isotype switching
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048289 ! isotype switching to IgE isotypes
relationship: regulates GO:0048289 ! isotype switching to IgE isotypes

[Term]
id: GO:0048294
name: negative regulation of isotype switching to IgE isotypes
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching to IgE isotypes." [GOC:jid]
synonym: "down regulation of isotype switching to IgE isotypes" EXACT []
synonym: "down-regulation of isotype switching to IgE isotypes" EXACT []
synonym: "downregulation of isotype switching to IgE isotypes" EXACT []
synonym: "inhibition of isotype switching to IgE isotypes" NARROW []
synonym: "negative regulation of class switch recombination to IgE isotypes" EXACT []
synonym: "negative regulation of class switching to IgE isotypes" EXACT []
synonym: "negative regulation of isotype switch recombination to IgE isotypes" EXACT []
is_a: GO:0045829 ! negative regulation of isotype switching
is_a: GO:0048293 ! regulation of isotype switching to IgE isotypes
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048289 ! isotype switching to IgE isotypes
relationship: negatively_regulates GO:0048289 ! isotype switching to IgE isotypes

[Term]
id: GO:0048295
name: positive regulation of isotype switching to IgE isotypes
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of isotype switching to IgE isotypes." [GOC:jid]
synonym: "activation of isotype switching to IgE isotypes" NARROW []
synonym: "positive regulation of class switch recombination to IgE isotypes" EXACT []
synonym: "positive regulation of class switching to IgE isotypes" EXACT []
synonym: "positive regulation of isotype switch recombination to IgE isotypes" EXACT []
synonym: "stimulation of isotype switching to IgE isotypes" NARROW []
synonym: "up regulation of isotype switching to IgE isotypes" EXACT []
synonym: "up-regulation of isotype switching to IgE isotypes" EXACT []
synonym: "upregulation of isotype switching to IgE isotypes" EXACT []
is_a: GO:0045830 ! positive regulation of isotype switching
is_a: GO:0048293 ! regulation of isotype switching to IgE isotypes
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048289 ! isotype switching to IgE isotypes
relationship: positively_regulates GO:0048289 ! isotype switching to IgE isotypes

[Term]
id: GO:0048296
name: regulation of isotype switching to IgA isotypes
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of isotype switching to IgA isotypes." [GOC:jid]
synonym: "regulation of class switch recombination to IgA isotypes" EXACT []
synonym: "regulation of class switching to IgA isotypes" EXACT []
synonym: "regulation of isotype switch recombination to IgA isotypes" EXACT []
is_a: GO:0045191 ! regulation of isotype switching
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048290 ! isotype switching to IgA isotypes
relationship: regulates GO:0048290 ! isotype switching to IgA isotypes

[Term]
id: GO:0048297
name: negative regulation of isotype switching to IgA isotypes
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching to IgA isotypes." [GOC:jid]
synonym: "down regulation of isotype switching to IgA isotypes" EXACT []
synonym: "down-regulation of isotype switching to IgA isotypes" EXACT []
synonym: "downregulation of isotype switching to IgA isotypes" EXACT []
synonym: "inhibition of isotype switching to IgA isotypes" NARROW []
synonym: "negative regulation of class switch recombination to IgA isotypes" EXACT []
synonym: "negative regulation of class switching to IgA isotypes" EXACT []
synonym: "negative regulation of isotype switch recombination to IgA isotypes" EXACT []
is_a: GO:0045829 ! negative regulation of isotype switching
is_a: GO:0048296 ! regulation of isotype switching to IgA isotypes
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048290 ! isotype switching to IgA isotypes
relationship: negatively_regulates GO:0048290 ! isotype switching to IgA isotypes

[Term]
id: GO:0048298
name: positive regulation of isotype switching to IgA isotypes
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of isotype switching to IgA isotypes." [GOC:jid]
synonym: "activation of isotype switching to IgA isotypes" NARROW []
synonym: "positive regulation of class switch recombination to IgA isotypes" EXACT []
synonym: "positive regulation of class switching to IgA isotypes" EXACT []
synonym: "positive regulation of isotype switch recombination to IgA isotypes" EXACT []
synonym: "stimulation of isotype switching to IgA isotypes" NARROW []
synonym: "up regulation of isotype switching to IgA isotypes" EXACT []
synonym: "up-regulation of isotype switching to IgA isotypes" EXACT []
synonym: "upregulation of isotype switching to IgA isotypes" EXACT []
is_a: GO:0045830 ! positive regulation of isotype switching
is_a: GO:0048296 ! regulation of isotype switching to IgA isotypes
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048290 ! isotype switching to IgA isotypes
relationship: positively_regulates GO:0048290 ! isotype switching to IgA isotypes

[Term]
id: GO:0048299
name: regulation of isotype switching to IgD isotypes
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of isotype switching to IgD isotypes." [GOC:jid]
synonym: "regulation of class switch recombination to IgD isotypes" EXACT []
synonym: "regulation of class switching to IgD isotypes" EXACT []
synonym: "regulation of isotype switch recombination to IgD isotypes" EXACT []
is_a: GO:0045191 ! regulation of isotype switching
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048292 ! isotype switching to IgD isotypes
relationship: regulates GO:0048292 ! isotype switching to IgD isotypes

[Term]
id: GO:0048300
name: negative regulation of isotype switching to IgD isotypes
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching to IgD isotypes." [GOC:jid]
synonym: "down regulation of isotype switching to IgD isotypes" EXACT []
synonym: "down-regulation of isotype switching to IgD isotypes" EXACT []
synonym: "downregulation of isotype switching to IgD isotypes" EXACT []
synonym: "inhibition of isotype switching to IgD isotypes" NARROW []
synonym: "negative regulation of class switch recombination to IgD isotypes" EXACT []
synonym: "negative regulation of class switching to IgD isotypes" EXACT []
synonym: "negative regulation of isotype switch recombination to IgD isotypes" EXACT []
is_a: GO:0045829 ! negative regulation of isotype switching
is_a: GO:0048299 ! regulation of isotype switching to IgD isotypes
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048292 ! isotype switching to IgD isotypes
relationship: negatively_regulates GO:0048292 ! isotype switching to IgD isotypes

[Term]
id: GO:0048301
name: positive regulation of isotype switching to IgD isotypes
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of isotype switching to IgD isotypes." [GOC:jid]
synonym: "activation of isotype switching to IgD isotypes" NARROW []
synonym: "positive regulation of class switch recombination to IgD isotypes" EXACT []
synonym: "positive regulation of class switching to IgD isotypes" EXACT []
synonym: "positive regulation of isotype switch recombination to IgD isotypes" EXACT []
synonym: "stimulation of isotype switching to IgD isotypes" NARROW []
synonym: "up regulation of isotype switching to IgD isotypes" EXACT []
synonym: "up-regulation of isotype switching to IgD isotypes" EXACT []
synonym: "upregulation of isotype switching to IgD isotypes" EXACT []
is_a: GO:0045830 ! positive regulation of isotype switching
is_a: GO:0048299 ! regulation of isotype switching to IgD isotypes
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048292 ! isotype switching to IgD isotypes
relationship: positively_regulates GO:0048292 ! isotype switching to IgD isotypes

[Term]
id: GO:0048302
name: regulation of isotype switching to IgG isotypes
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of isotype switching to IgG isotypes." [GOC:jid]
synonym: "regulation of class switch recombination to IgG isotypes" EXACT []
synonym: "regulation of class switching to IgG isotypes" EXACT []
synonym: "regulation of isotype switch recombination to IgG isotypes" EXACT []
is_a: GO:0045191 ! regulation of isotype switching
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048291 ! isotype switching to IgG isotypes
relationship: regulates GO:0048291 ! isotype switching to IgG isotypes

[Term]
id: GO:0048303
name: negative regulation of isotype switching to IgG isotypes
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching to IgG isotypes." [GOC:jid]
synonym: "down regulation of isotype switching to IgG isotypes" EXACT []
synonym: "down-regulation of isotype switching to IgG isotypes" EXACT []
synonym: "downregulation of isotype switching to IgG isotypes" EXACT []
synonym: "inhibition of isotype switching to IgG isotypes" NARROW []
synonym: "negative regulation of class switch recombination to IgG isotypes" EXACT []
synonym: "negative regulation of class switching to IgG isotypes" EXACT []
synonym: "negative regulation of isotype switch recombination to IgG isotypes" EXACT []
is_a: GO:0045829 ! negative regulation of isotype switching
is_a: GO:0048302 ! regulation of isotype switching to IgG isotypes
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048291 ! isotype switching to IgG isotypes
relationship: negatively_regulates GO:0048291 ! isotype switching to IgG isotypes

[Term]
id: GO:0048304
name: positive regulation of isotype switching to IgG isotypes
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of isotype switching to IgG isotypes." [GOC:jid]
synonym: "activation of isotype switching to IgG isotypes" NARROW []
synonym: "positive regulation of class switch recombination to IgG isotypes" EXACT []
synonym: "positive regulation of class switching to IgG isotypes" EXACT []
synonym: "positive regulation of isotype switch recombination to IgG isotypes" EXACT []
synonym: "stimulation of isotype switching to IgG isotypes" NARROW []
synonym: "up regulation of isotype switching to IgG isotypes" EXACT []
synonym: "up-regulation of isotype switching to IgG isotypes" EXACT []
synonym: "upregulation of isotype switching to IgG isotypes" EXACT []
is_a: GO:0045830 ! positive regulation of isotype switching
is_a: GO:0048302 ! regulation of isotype switching to IgG isotypes
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048291 ! isotype switching to IgG isotypes
relationship: positively_regulates GO:0048291 ! isotype switching to IgG isotypes

[Term]
id: GO:0048305
name: immunoglobulin secretion
namespace: biological_process
def: "The regulated release of immunoglobulins from a B cell or plasma cell, whose mechanism includes the use of alternate polyadenylylation signals to favor the biosynthesis of secreted forms of immunoglobulin over membrane-bound immunoglobulin." [GOC:add, ISBN:0781735149, PMID:9185563]
synonym: "antibody secretion" EXACT []
is_a: GO:0009306 ! protein secretion
relationship: part_of GO:0002377 ! immunoglobulin production

[Term]
id: GO:0048306
name: calcium-dependent protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium." [GOC:jid, PMID:10485905]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0048307
name: ferredoxin-nitrite reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NH3 + 2 H2O + 6 oxidized ferredoxin = nitrite + 6 reduced ferredoxin + 7 H+." [EC:1.7.7.1, GOC:jid]
subset: gosubset_prok
synonym: "ammonia:ferredoxin oxidoreductase activity" EXACT [EC:1.7.7.1]
xref: EC:1.7.7.1
xref: MetaCyc:FERREDOXIN--NITRITE-REDUCTASE-RXN
is_a: GO:0016664 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulfur protein as acceptor
is_a: GO:0098809 ! nitrite reductase activity

[Term]
id: GO:0048308
name: organelle inheritance
namespace: biological_process
def: "The partitioning of organelles between daughter cells at cell division." [GOC:jid]
subset: goslim_pir
subset: goslim_yeast
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0048309
name: endoplasmic reticulum inheritance
namespace: biological_process
def: "The partitioning of endoplasmic reticulum between daughter cells at cell division." [GOC:jid]
synonym: "ER inheritance" EXACT []
is_a: GO:0007029 ! endoplasmic reticulum organization
is_a: GO:0048308 ! organelle inheritance

[Term]
id: GO:0048310
name: nucleus inheritance
namespace: biological_process
def: "The partitioning of nuclei between daughter cells at cell division." [GOC:jid]
synonym: "cell nucleus inheritance" EXACT []
is_a: GO:0006997 ! nucleus organization
is_a: GO:0048308 ! organelle inheritance

[Term]
id: GO:0048311
name: mitochondrion distribution
namespace: biological_process
def: "Any process that establishes the spatial arrangement of mitochondria between and within cells." [GOC:jid]
synonym: "distribution of mitochondria" EXACT []
synonym: "mitochondrial distribution" EXACT []
synonym: "positioning of mitochondria" RELATED []
is_a: GO:0007005 ! mitochondrion organization
is_a: GO:0051646 ! mitochondrion localization
is_a: GO:1902580 ! single-organism cellular localization
is_a: GO:1902589 ! single-organism organelle organization

[Term]
id: GO:0048312
name: intracellular distribution of mitochondria
namespace: biological_process
def: "Any process that establishes the spatial arrangement of mitochondria within the cell." [GOC:jid]
synonym: "mitochondria positioning within cell" EXACT []
synonym: "mitochondrion positioning within cell" EXACT []
is_a: GO:0048311 ! mitochondrion distribution
intersection_of: GO:0048311 ! mitochondrion distribution
intersection_of: occurs_in GO:0005622 ! intracellular
relationship: occurs_in GO:0005622 ! intracellular

[Term]
id: GO:0048313
name: Golgi inheritance
namespace: biological_process
def: "The partitioning of Golgi apparatus between daughter cells at cell division." [GOC:jid, PMID:12851069]
synonym: "Golgi division" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "Golgi partitioning" EXACT []
is_a: GO:0007030 ! Golgi organization
is_a: GO:0048308 ! organelle inheritance

[Term]
id: GO:0048314
name: embryo sac morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the embryo sac are generated and organized. The embryo sac develops from the megaspore in heterosporous plants." [GOC:jid, GOC:mtg_plant, http://www.bio.uu.nl]
synonym: "female gametophyte morphogenesis" EXACT []
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0009561 ! megagametogenesis

[Term]
id: GO:0048315
name: conidium formation
namespace: biological_process
def: "Formation of asexual, nonmotile spores in fungi, by conversion of hyphal elements or arising from specialized sporogenous cells." [ISBN:0963117211, PMID:2524423, PMID:9529886]
synonym: "conidia biosynthesis" EXACT []
synonym: "conidia formation" EXACT []
is_a: GO:0030436 ! asexual sporulation
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis

[Term]
id: GO:0048316
name: seed development
namespace: biological_process
def: "The process whose specific outcome is the progression of the seed over time, from its formation to the mature structure. A seed is a propagating organ formed in the sexual reproductive cycle of gymnosperms and angiosperms, consisting of a protective coat enclosing an embryo and food reserves." [GOC:jid, PO:0009010]
is_a: GO:0009791 ! post-embryonic development
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0048608 ! reproductive structure development
relationship: part_of GO:0010154 ! fruit development

[Term]
id: GO:0048317
name: seed morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the seed are generated and organized." [GOC:go_curators]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0009886 ! post-embryonic morphogenesis
relationship: part_of GO:0048316 ! seed development

[Term]
id: GO:0048318
name: axial mesoderm development
namespace: biological_process
def: "The process whose specific outcome is the progression of the axial mesoderm over time, from its formation to the mature structure. The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord." [GOC:dgh]
is_a: GO:0007498 ! mesoderm development

[Term]
id: GO:0048319
name: axial mesoderm morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the axial mesoderm are generated and organized." [GOC:go_curators]
is_a: GO:0048332 ! mesoderm morphogenesis
relationship: part_of GO:0048318 ! axial mesoderm development

[Term]
id: GO:0048320
name: axial mesoderm formation
namespace: biological_process
def: "The process that gives rise to the axial mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:dgh]
is_a: GO:0001707 ! mesoderm formation
relationship: part_of GO:0048319 ! axial mesoderm morphogenesis

[Term]
id: GO:0048321
name: axial mesodermal cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an axial mesoderm cell." [GOC:dgh]
synonym: "axial mesoderm cell differentiation" EXACT []
is_a: GO:0048333 ! mesodermal cell differentiation
relationship: part_of GO:0048320 ! axial mesoderm formation

[Term]
id: GO:0048322
name: axial mesodermal cell fate commitment
namespace: biological_process
def: "The process in which a cell becomes committed to become an axial mesoderm cell." [GOC:dgh]
synonym: "axial mesoderm cell fate commitment" EXACT []
is_a: GO:0001710 ! mesodermal cell fate commitment
relationship: part_of GO:0048321 ! axial mesodermal cell differentiation

[Term]
id: GO:0048323
name: axial mesodermal cell fate determination
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into an axial mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:dgh]
synonym: "axial mesoderm cell fate determination" EXACT []
is_a: GO:0007500 ! mesodermal cell fate determination
relationship: part_of GO:0048322 ! axial mesodermal cell fate commitment

[Term]
id: GO:0048324
name: regulation of axial mesodermal cell fate determination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of axial mesoderm cell fate determination." [GOC:dgh]
is_a: GO:0048334 ! regulation of mesodermal cell fate determination
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048323 ! axial mesodermal cell fate determination
relationship: regulates GO:0048323 ! axial mesodermal cell fate determination

[Term]
id: GO:0048325
name: negative regulation of axial mesodermal cell fate determination
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of axial mesoderm cell fate determination." [GOC:dgh]
synonym: "down regulation of axial mesodermal cell fate determination" EXACT []
synonym: "down-regulation of axial mesodermal cell fate determination" EXACT []
synonym: "downregulation of axial mesodermal cell fate determination" EXACT []
synonym: "inhibition of axial mesodermal cell fate determination" NARROW []
is_a: GO:0048324 ! regulation of axial mesodermal cell fate determination
is_a: GO:0048335 ! negative regulation of mesodermal cell fate determination
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048323 ! axial mesodermal cell fate determination
relationship: negatively_regulates GO:0048323 ! axial mesodermal cell fate determination

[Term]
id: GO:0048326
name: positive regulation of axial mesodermal cell fate determination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of axial mesoderm cell fate determination." [GOC:dgh]
synonym: "activation of axial mesodermal cell fate determination" NARROW []
synonym: "stimulation of axial mesodermal cell fate determination" NARROW []
synonym: "up regulation of axial mesodermal cell fate determination" EXACT []
synonym: "up-regulation of axial mesodermal cell fate determination" EXACT []
synonym: "upregulation of axial mesodermal cell fate determination" EXACT []
is_a: GO:0048324 ! regulation of axial mesodermal cell fate determination
is_a: GO:0048336 ! positive regulation of mesodermal cell fate determination
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048323 ! axial mesodermal cell fate determination
relationship: positively_regulates GO:0048323 ! axial mesodermal cell fate determination

[Term]
id: GO:0048327
name: axial mesodermal cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into an axial mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:dgh]
synonym: "axial mesoderm cell fate specification" EXACT []
is_a: GO:0007501 ! mesodermal cell fate specification
relationship: part_of GO:0048322 ! axial mesodermal cell fate commitment

[Term]
id: GO:0048328
name: regulation of axial mesodermal cell fate specification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of axial mesoderm cell fate specification." [GOC:dgh]
is_a: GO:0042661 ! regulation of mesodermal cell fate specification
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048327 ! axial mesodermal cell fate specification
relationship: regulates GO:0048327 ! axial mesodermal cell fate specification

[Term]
id: GO:0048329
name: negative regulation of axial mesodermal cell fate specification
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of axial mesoderm cell fate specification." [GOC:dgh]
synonym: "down regulation of axial mesodermal cell fate specification" EXACT []
synonym: "down-regulation of axial mesodermal cell fate specification" EXACT []
synonym: "downregulation of axial mesodermal cell fate specification" EXACT []
synonym: "inhibition of axial mesodermal cell fate specification" NARROW []
is_a: GO:0042662 ! negative regulation of mesodermal cell fate specification
is_a: GO:0048328 ! regulation of axial mesodermal cell fate specification
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048327 ! axial mesodermal cell fate specification
relationship: negatively_regulates GO:0048327 ! axial mesodermal cell fate specification

[Term]
id: GO:0048330
name: positive regulation of axial mesodermal cell fate specification
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of axial mesoderm cell fate specification." [GOC:dgh]
synonym: "activation of axial mesodermal cell fate specification" NARROW []
synonym: "stimulation of axial mesodermal cell fate specification" NARROW []
synonym: "up regulation of axial mesodermal cell fate specification" EXACT []
synonym: "up-regulation of axial mesodermal cell fate specification" EXACT []
synonym: "upregulation of axial mesodermal cell fate specification" EXACT []
is_a: GO:0048328 ! regulation of axial mesodermal cell fate specification
is_a: GO:0048337 ! positive regulation of mesodermal cell fate specification
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048327 ! axial mesodermal cell fate specification
relationship: positively_regulates GO:0048327 ! axial mesodermal cell fate specification

[Term]
id: GO:0048331
name: axial mesoderm structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the axial mesoderm. This process pertains to the physical shaping of a rudimentary structure." [GOC:dgh]
synonym: "axial mesoderm structural organisation" EXACT [GOC:curators]
is_a: GO:0048338 ! mesoderm structural organization
relationship: part_of GO:0048319 ! axial mesoderm morphogenesis

[Term]
id: GO:0048332
name: mesoderm morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the mesoderm are generated and organized." [GOC:go_curators]
is_a: GO:0048729 ! tissue morphogenesis
relationship: part_of GO:0007498 ! mesoderm development

[Term]
id: GO:0048333
name: mesodermal cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a mesoderm cell." [GOC:dgh]
synonym: "mesoderm cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0001707 ! mesoderm formation

[Term]
id: GO:0048334
name: regulation of mesodermal cell fate determination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesoderm cell fate determination." [GOC:dgh]
is_a: GO:0010453 ! regulation of cell fate commitment
is_a: GO:0010470 ! regulation of gastrulation
is_a: GO:2000027 ! regulation of organ morphogenesis
is_a: GO:2000380 ! regulation of mesoderm development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007500 ! mesodermal cell fate determination
relationship: regulates GO:0007500 ! mesodermal cell fate determination

[Term]
id: GO:0048335
name: negative regulation of mesodermal cell fate determination
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mesoderm cell fate determination." [GOC:dgh]
synonym: "down regulation of mesodermal cell fate determination" EXACT []
synonym: "down-regulation of mesodermal cell fate determination" EXACT []
synonym: "downregulation of mesodermal cell fate determination" EXACT []
synonym: "inhibition of mesodermal cell fate determination" NARROW []
is_a: GO:0010454 ! negative regulation of cell fate commitment
is_a: GO:0048334 ! regulation of mesodermal cell fate determination
is_a: GO:2000381 ! negative regulation of mesoderm development
is_a: GO:2000542 ! negative regulation of gastrulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007500 ! mesodermal cell fate determination
relationship: negatively_regulates GO:0007500 ! mesodermal cell fate determination

[Term]
id: GO:0048336
name: positive regulation of mesodermal cell fate determination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mesoderm cell fate determination." [GOC:dgh]
synonym: "activation of mesodermal cell fate determination" NARROW []
synonym: "stimulation of mesodermal cell fate determination" NARROW []
synonym: "up regulation of mesodermal cell fate determination" EXACT []
synonym: "up-regulation of mesodermal cell fate determination" EXACT []
synonym: "upregulation of mesodermal cell fate determination" EXACT []
is_a: GO:0010455 ! positive regulation of cell fate commitment
is_a: GO:0048334 ! regulation of mesodermal cell fate determination
is_a: GO:2000382 ! positive regulation of mesoderm development
is_a: GO:2000543 ! positive regulation of gastrulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007500 ! mesodermal cell fate determination
relationship: positively_regulates GO:0007500 ! mesodermal cell fate determination

[Term]
id: GO:0048337
name: positive regulation of mesodermal cell fate specification
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mesoderm cell fate specification." [GOC:dgh]
synonym: "activation of mesodermal cell fate specification" NARROW []
synonym: "stimulation of mesodermal cell fate specification" NARROW []
synonym: "up regulation of mesodermal cell fate specification" EXACT []
synonym: "up-regulation of mesodermal cell fate specification" EXACT []
synonym: "upregulation of mesodermal cell fate specification" EXACT []
is_a: GO:0042660 ! positive regulation of cell fate specification
is_a: GO:0042661 ! regulation of mesodermal cell fate specification
is_a: GO:2000382 ! positive regulation of mesoderm development
is_a: GO:2000543 ! positive regulation of gastrulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007501 ! mesodermal cell fate specification
relationship: positively_regulates GO:0007501 ! mesodermal cell fate specification

[Term]
id: GO:0048338
name: mesoderm structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the mesoderm. This process pertains to the physical shaping of a rudimentary structure." [GOC:dgh]
synonym: "mesoderm structural organisation" EXACT [GOC:curators]
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0048332 ! mesoderm morphogenesis

[Term]
id: GO:0048339
name: paraxial mesoderm development
namespace: biological_process
def: "The process whose specific outcome is the progression of the paraxial mesoderm over time, from its formation to the mature structure. The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube." [GOC:dgh]
is_a: GO:0007498 ! mesoderm development
is_a: GO:0060485 ! mesenchyme development

[Term]
id: GO:0048340
name: paraxial mesoderm morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the paraxial mesoderm are generated and organized." [GOC:go_curators]
is_a: GO:0048332 ! mesoderm morphogenesis
is_a: GO:0072132 ! mesenchyme morphogenesis
relationship: part_of GO:0048339 ! paraxial mesoderm development

[Term]
id: GO:0048341
name: paraxial mesoderm formation
namespace: biological_process
def: "The process that gives rise to the paraxial mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:dgh]
is_a: GO:0001707 ! mesoderm formation
relationship: part_of GO:0048340 ! paraxial mesoderm morphogenesis

[Term]
id: GO:0048342
name: paraxial mesodermal cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a paraxial mesoderm cell." [GOC:dgh]
is_a: GO:0048333 ! mesodermal cell differentiation
relationship: part_of GO:0048341 ! paraxial mesoderm formation

[Term]
id: GO:0048343
name: paraxial mesodermal cell fate commitment
namespace: biological_process
def: "The process in which a cell becomes committed to become a paraxial mesoderm cell." [GOC:dgh]
is_a: GO:0001710 ! mesodermal cell fate commitment
relationship: part_of GO:0048342 ! paraxial mesodermal cell differentiation

[Term]
id: GO:0048344
name: paraxial mesodermal cell fate determination
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a paraxial mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:dgh]
is_a: GO:0007500 ! mesodermal cell fate determination
relationship: part_of GO:0048343 ! paraxial mesodermal cell fate commitment

[Term]
id: GO:0048345
name: regulation of paraxial mesodermal cell fate determination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of paraxial mesoderm cell fate determination." [GOC:dgh]
is_a: GO:0048334 ! regulation of mesodermal cell fate determination
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048344 ! paraxial mesodermal cell fate determination
relationship: regulates GO:0048344 ! paraxial mesodermal cell fate determination

[Term]
id: GO:0048346
name: positive regulation of paraxial mesodermal cell fate determination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of paraxial mesoderm cell fate determination." [GOC:dgh]
synonym: "activation of paraxial mesodermal cell fate determination" NARROW []
synonym: "stimulation of paraxial mesodermal cell fate determination" NARROW []
synonym: "up regulation of paraxial mesodermal cell fate determination" EXACT []
synonym: "up-regulation of paraxial mesodermal cell fate determination" EXACT []
synonym: "upregulation of paraxial mesodermal cell fate determination" EXACT []
is_a: GO:0048336 ! positive regulation of mesodermal cell fate determination
is_a: GO:0048345 ! regulation of paraxial mesodermal cell fate determination
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048344 ! paraxial mesodermal cell fate determination
relationship: positively_regulates GO:0048344 ! paraxial mesodermal cell fate determination

[Term]
id: GO:0048347
name: negative regulation of paraxial mesodermal cell fate determination
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of paraxial mesoderm cell fate determination." [GOC:dgh]
synonym: "down regulation of paraxial mesodermal cell fate determination" EXACT []
synonym: "down-regulation of paraxial mesodermal cell fate determination" EXACT []
synonym: "downregulation of paraxial mesodermal cell fate determination" EXACT []
synonym: "inhibition of paraxial mesodermal cell fate determination" NARROW []
is_a: GO:0048335 ! negative regulation of mesodermal cell fate determination
is_a: GO:0048345 ! regulation of paraxial mesodermal cell fate determination
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048344 ! paraxial mesodermal cell fate determination
relationship: negatively_regulates GO:0048344 ! paraxial mesodermal cell fate determination

[Term]
id: GO:0048348
name: paraxial mesodermal cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a paraxial mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:dgh]
is_a: GO:0007501 ! mesodermal cell fate specification
relationship: part_of GO:0048343 ! paraxial mesodermal cell fate commitment

[Term]
id: GO:0048349
name: regulation of paraxial mesodermal cell fate specification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of paraxial mesoderm cell fate specification." [GOC:dgh]
is_a: GO:0042661 ! regulation of mesodermal cell fate specification
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048348 ! paraxial mesodermal cell fate specification
relationship: regulates GO:0048348 ! paraxial mesodermal cell fate specification

[Term]
id: GO:0048350
name: positive regulation of paraxial mesodermal cell fate specification
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of paraxial mesoderm cell fate specification." [GOC:dgh]
synonym: "activation of paraxial mesodermal cell fate specification" NARROW []
synonym: "stimulation of paraxial mesodermal cell fate specification" NARROW []
synonym: "up regulation of paraxial mesodermal cell fate specification" EXACT []
synonym: "up-regulation of paraxial mesodermal cell fate specification" EXACT []
synonym: "upregulation of paraxial mesodermal cell fate specification" EXACT []
is_a: GO:0048337 ! positive regulation of mesodermal cell fate specification
is_a: GO:0048349 ! regulation of paraxial mesodermal cell fate specification
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048348 ! paraxial mesodermal cell fate specification
relationship: positively_regulates GO:0048348 ! paraxial mesodermal cell fate specification

[Term]
id: GO:0048351
name: negative regulation of paraxial mesodermal cell fate specification
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of paraxial mesoderm cell fate specification." [GOC:dgh]
synonym: "down regulation of paraxial mesodermal cell fate specification" EXACT []
synonym: "down-regulation of paraxial mesodermal cell fate specification" EXACT []
synonym: "downregulation of paraxial mesodermal cell fate specification" EXACT []
synonym: "inhibition of paraxial mesodermal cell fate specification" NARROW []
is_a: GO:0042662 ! negative regulation of mesodermal cell fate specification
is_a: GO:0048349 ! regulation of paraxial mesodermal cell fate specification
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048348 ! paraxial mesodermal cell fate specification
relationship: negatively_regulates GO:0048348 ! paraxial mesodermal cell fate specification

[Term]
id: GO:0048352
name: paraxial mesoderm structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the paraxial mesoderm. This process pertains to the physical shaping of a rudimentary structure." [GOC:dgh]
synonym: "paraxial mesoderm structural organisation" EXACT [GOC:curators]
is_a: GO:0048338 ! mesoderm structural organization
relationship: part_of GO:0048340 ! paraxial mesoderm morphogenesis

[Term]
id: GO:0048353
name: primary endosperm nucleus
namespace: cellular_component
def: "Nucleus resulting from the fusion of the male gamete and two polar nuclei in the central cell of the embryo sac." [ISBN:0471245208]
is_a: GO:0005634 ! nucleus

[Term]
id: GO:0048354
name: mucilage biosynthetic process involved in seed coat development
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of mucilage that occur as part of seed coat development; mucilage is normally synthesized during seed coat development." [GOC:dph, GOC:jid, GOC:tb]
synonym: "mucilage anabolism during seed coat development" EXACT []
synonym: "mucilage biosynthetic process during seed coat development" RELATED [GOC:dph, GOC:tb]
synonym: "mucilage formation during seed coat development" EXACT []
synonym: "mucilage synthesis during seed coat development" EXACT []
is_a: GO:0010192 ! mucilage biosynthetic process
is_a: GO:0048359 ! mucilage metabolic process involved in seed coat development
intersection_of: GO:0010192 ! mucilage biosynthetic process
intersection_of: part_of GO:0010214 ! seed coat development
relationship: part_of GO:0010214 ! seed coat development

[Term]
id: GO:0048355
name: root cap mucilage biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of mucilage that occur in the root cap; mucilage is normally synthesized during root growth." [GOC:jid]
synonym: "root cap mucilage anabolism" EXACT []
synonym: "root cap mucilage biosynthesis" EXACT []
synonym: "root cap mucilage formation" EXACT []
synonym: "root cap mucilage synthesis" EXACT []
is_a: GO:0010192 ! mucilage biosynthetic process
relationship: part_of GO:0048360 ! root cap mucilage metabolic process

[Term]
id: GO:0048356
name: root epithelial mucilage biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of mucilage that occur in the root epithelium; mucilage is normally synthesized during root growth." [GOC:jid]
synonym: "root epithelial mucilage anabolism" EXACT []
synonym: "root epithelial mucilage biosynthesis" EXACT []
synonym: "root epithelial mucilage formation" EXACT []
synonym: "root epithelial mucilage synthesis" EXACT []
is_a: GO:0010192 ! mucilage biosynthetic process
relationship: part_of GO:0048361 ! root epithelial mucilage metabolic process

[Term]
id: GO:0048357
name: pedicel mucilage biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of mucilage that occur in the flower stem." [GOC:jid]
synonym: "pedicel mucilage anabolism" EXACT []
synonym: "pedicel mucilage biosynthesis" EXACT []
synonym: "pedicel mucilage formation" EXACT []
synonym: "pedicel mucilage synthesis" EXACT []
is_a: GO:0010192 ! mucilage biosynthetic process
relationship: part_of GO:0048362 ! pedicel mucilage metabolic process

[Term]
id: GO:0048358
name: mucilage pectin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the pectin component of mucilage." [GOC:jid]
synonym: "mucilage pectin anabolism" EXACT []
synonym: "mucilage pectin biosynthesis" EXACT []
synonym: "mucilage pectin formation" EXACT []
synonym: "mucilage pectin synthesis" EXACT []
is_a: GO:0045489 ! pectin biosynthetic process
is_a: GO:0048363 ! mucilage pectin metabolic process
relationship: part_of GO:0010192 ! mucilage biosynthetic process

[Term]
id: GO:0048359
name: mucilage metabolic process involved in seed coat development
namespace: biological_process
def: "The chemical reactions and pathways involving mucilage that occur as part of seed coat development; mucilage is normally synthesized during seed coat development." [GOC:dph, GOC:jid, GOC:tb]
synonym: "mucilage metabolic process during seed coat development" RELATED [GOC:dph, GOC:tb]
synonym: "mucilage metabolism during seed coat development" EXACT []
is_a: GO:0010191 ! mucilage metabolic process
is_a: GO:0022414 ! reproductive process
intersection_of: GO:0010191 ! mucilage metabolic process
intersection_of: part_of GO:0010214 ! seed coat development
relationship: part_of GO:0010214 ! seed coat development

[Term]
id: GO:0048360
name: root cap mucilage metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mucilage that occur in the root cap; mucilage is normally synthesized during root growth." [GOC:jid]
synonym: "root cap mucilage metabolism" EXACT []
is_a: GO:0010191 ! mucilage metabolic process

[Term]
id: GO:0048361
name: root epithelial mucilage metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mucilage that occur in the root epithelium; mucilage is normally synthesized during root growth." [GOC:jid]
synonym: "root epithelial mucilage metabolism" EXACT []
is_a: GO:0010191 ! mucilage metabolic process

[Term]
id: GO:0048362
name: pedicel mucilage metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mucilage that occur in the flower stem." [GOC:jid]
synonym: "pedicel mucilage metabolism" EXACT []
is_a: GO:0010191 ! mucilage metabolic process

[Term]
id: GO:0048363
name: mucilage pectin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the pectin component of mucilage." [GOC:jid]
synonym: "mucilage pectin metabolism" EXACT []
is_a: GO:0045488 ! pectin metabolic process
relationship: part_of GO:0010191 ! mucilage metabolic process

[Term]
id: GO:0048364
name: root development
namespace: biological_process
def: "The process whose specific outcome is the progression of the root over time, from its formation to the mature structure. The root is the water- and mineral-absorbing part of a plant which is usually underground, does not bear leaves, tends to grow downwards and is typically derived from the radicle of the embryo." [GOC:jid, PO:0009005]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0099402 ! plant organ development
relationship: part_of GO:0022622 ! root system development

[Term]
id: GO:0048365
name: Rac GTPase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with Rac protein, any member of the Rac subfamily of the Ras superfamily of monomeric GTPases." [GOC:ebc, PMID:11702775]
is_a: GO:0017048 ! Rho GTPase binding

[Term]
id: GO:0048366
name: leaf development
namespace: biological_process
def: "The process whose specific outcome is the progression of the leaf over time, from its formation to the mature structure." [GOC:go_curators]
is_a: GO:0048827 ! phyllome development

[Term]
id: GO:0048367
name: shoot system development
namespace: biological_process
alt_id: GO:0022621
def: "The process whose specific outcome is the progression of the shoot system over time, from its formation to the mature structure." [GOC:go_curators]
synonym: "shoot development" EXACT []
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048731 ! system development

[Term]
id: GO:0048368
name: lateral mesoderm development
namespace: biological_process
def: "The process whose specific outcome is the progression of the lateral mesoderm over time, from its formation to the mature structure." [GOC:go_curators]
synonym: "lateral plate mesoderm development" EXACT []
is_a: GO:0007498 ! mesoderm development
is_a: GO:0060485 ! mesenchyme development

[Term]
id: GO:0048369
name: lateral mesoderm morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the lateral mesoderm are generated and organized." [GOC:go_curators]
synonym: "lateral plate mesoderm morphogenesis" EXACT []
is_a: GO:0048332 ! mesoderm morphogenesis
is_a: GO:0072132 ! mesenchyme morphogenesis
relationship: part_of GO:0048368 ! lateral mesoderm development

[Term]
id: GO:0048370
name: lateral mesoderm formation
namespace: biological_process
def: "The process that gives rise to the lateral mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:jid]
synonym: "lateral plate mesoderm biosynthesis" EXACT []
synonym: "lateral plate mesoderm formation" EXACT []
is_a: GO:0001707 ! mesoderm formation
relationship: part_of GO:0048369 ! lateral mesoderm morphogenesis

[Term]
id: GO:0048371
name: lateral mesodermal cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a lateral mesoderm cell." [GOC:jid]
synonym: "lateral mesoderm cell differentiation" EXACT []
synonym: "lateral plate mesoderm cell differentiation" EXACT []
synonym: "lateral plate mesodermal cell differentiation" EXACT []
is_a: GO:0048333 ! mesodermal cell differentiation
relationship: part_of GO:0048370 ! lateral mesoderm formation

[Term]
id: GO:0048372
name: lateral mesodermal cell fate commitment
namespace: biological_process
def: "The process in which a cell becomes committed to become a lateral mesoderm cell." [GOC:jid]
synonym: "lateral mesoderm cell fate commitment" EXACT []
synonym: "lateral plate mesoderm cell fate commitment" EXACT []
synonym: "lateral plate mesodermal cell fate commitment" EXACT []
is_a: GO:0001710 ! mesodermal cell fate commitment
relationship: part_of GO:0048371 ! lateral mesodermal cell differentiation

[Term]
id: GO:0048373
name: lateral mesodermal cell fate determination
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a lateral mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:jid]
synonym: "lateral mesoderm cell fate determination" EXACT []
synonym: "lateral plate mesoderm cell fate determination" EXACT []
synonym: "lateral plate mesodermal cell fate determination" EXACT []
is_a: GO:0007500 ! mesodermal cell fate determination
relationship: part_of GO:0048372 ! lateral mesodermal cell fate commitment

[Term]
id: GO:0048374
name: regulation of lateral mesodermal cell fate determination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lateral mesoderm cell fate determination." [GOC:jid]
synonym: "regulation of lateral mesoderm cell fate determination" EXACT []
synonym: "regulation of lateral plate mesoderm cell fate determination" EXACT []
synonym: "regulation of lateral plate mesodermal cell fate determination" EXACT []
is_a: GO:0048334 ! regulation of mesodermal cell fate determination
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048373 ! lateral mesodermal cell fate determination
relationship: regulates GO:0048373 ! lateral mesodermal cell fate determination

[Term]
id: GO:0048375
name: negative regulation of lateral mesodermal cell fate determination
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lateral mesoderm cell fate determination." [GOC:jid]
synonym: "down regulation of lateral mesodermal cell fate determination" EXACT []
synonym: "down-regulation of lateral mesodermal cell fate determination" EXACT []
synonym: "downregulation of lateral mesodermal cell fate determination" EXACT []
synonym: "inhibition of lateral mesodermal cell fate determination" NARROW []
synonym: "negative regulation of lateral plate mesodermal cell fate determination" EXACT []
is_a: GO:0048335 ! negative regulation of mesodermal cell fate determination
is_a: GO:0048374 ! regulation of lateral mesodermal cell fate determination
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048373 ! lateral mesodermal cell fate determination
relationship: negatively_regulates GO:0048373 ! lateral mesodermal cell fate determination

[Term]
id: GO:0048376
name: positive regulation of lateral mesodermal cell fate determination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lateral mesoderm cell fate determination." [GOC:jid]
synonym: "activation of lateral mesodermal cell fate determination" NARROW []
synonym: "positive regulation of lateral plate mesodermal cell fate determination" EXACT []
synonym: "stimulation of lateral mesodermal cell fate determination" NARROW []
synonym: "up regulation of lateral mesodermal cell fate determination" EXACT []
synonym: "up-regulation of lateral mesodermal cell fate determination" EXACT []
synonym: "upregulation of lateral mesodermal cell fate determination" EXACT []
is_a: GO:0048336 ! positive regulation of mesodermal cell fate determination
is_a: GO:0048374 ! regulation of lateral mesodermal cell fate determination
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048373 ! lateral mesodermal cell fate determination
relationship: positively_regulates GO:0048373 ! lateral mesodermal cell fate determination

[Term]
id: GO:0048377
name: lateral mesodermal cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a lateral mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:jid]
synonym: "lateral mesoderm cell fate specification" EXACT []
synonym: "lateral plate mesoderm cell fate specification" EXACT []
synonym: "lateral plate mesodermal cell fate specification" EXACT []
is_a: GO:0007501 ! mesodermal cell fate specification
relationship: part_of GO:0048372 ! lateral mesodermal cell fate commitment

[Term]
id: GO:0048378
name: regulation of lateral mesodermal cell fate specification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lateral mesoderm cell fate specification." [GOC:jid]
synonym: "regulation of lateral plate mesodermal cell fate specification" EXACT []
is_a: GO:0042661 ! regulation of mesodermal cell fate specification
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048377 ! lateral mesodermal cell fate specification
relationship: regulates GO:0048377 ! lateral mesodermal cell fate specification

[Term]
id: GO:0048379
name: positive regulation of lateral mesodermal cell fate specification
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lateral mesoderm cell fate specification." [GOC:jid]
synonym: "activation of lateral mesodermal cell fate specification" NARROW []
synonym: "positive regulation of lateral plate mesodermal cell fate specification" EXACT []
synonym: "stimulation of lateral mesodermal cell fate specification" NARROW []
synonym: "up regulation of lateral mesodermal cell fate specification" EXACT []
synonym: "up-regulation of lateral mesodermal cell fate specification" EXACT []
synonym: "upregulation of lateral mesodermal cell fate specification" EXACT []
is_a: GO:0048337 ! positive regulation of mesodermal cell fate specification
is_a: GO:0048378 ! regulation of lateral mesodermal cell fate specification
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048377 ! lateral mesodermal cell fate specification
relationship: positively_regulates GO:0048377 ! lateral mesodermal cell fate specification

[Term]
id: GO:0048380
name: negative regulation of lateral mesodermal cell fate specification
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lateral mesoderm cell fate specification." [GOC:jid]
synonym: "down regulation of lateral mesodermal cell fate specification" EXACT []
synonym: "down-regulation of lateral mesodermal cell fate specification" EXACT []
synonym: "downregulation of lateral mesodermal cell fate specification" EXACT []
synonym: "inhibition of lateral mesodermal cell fate specification" NARROW []
synonym: "negative regulation of lateral plate mesodermal cell fate specification" EXACT []
is_a: GO:0042662 ! negative regulation of mesodermal cell fate specification
is_a: GO:0048378 ! regulation of lateral mesodermal cell fate specification
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048377 ! lateral mesodermal cell fate specification
relationship: negatively_regulates GO:0048377 ! lateral mesodermal cell fate specification

[Term]
id: GO:0048381
name: lateral mesoderm structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the lateral mesoderm. This process pertains to the physical shaping of a rudimentary structure." [GOC:jid]
synonym: "lateral mesoderm structural organisation" EXACT [GOC:curators]
synonym: "lateral plate mesoderm structural organization" EXACT []
is_a: GO:0048338 ! mesoderm structural organization
relationship: part_of GO:0048369 ! lateral mesoderm morphogenesis

[Term]
id: GO:0048382
name: mesendoderm development
namespace: biological_process
def: "The process whose specific outcome is the progression of the mesendoderm over time, from its formation to the mature structure. In animal embryos, mesendoderm development gives rise to both mesoderm and endoderm tissues." [GOC:jid]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007492 ! endoderm development
relationship: part_of GO:0007498 ! mesoderm development

[Term]
id: GO:0048383
name: mesectoderm development
namespace: biological_process
def: "The process whose specific outcome is the progression of the mesectoderm over time, from its formation to the mature structure. In animal embryos, mesectoderm development processes give rise to both mesoderm and ectoderm tissues." [GOC:jid]
is_a: GO:0009888 ! tissue development
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0007398 ! ectoderm development
relationship: part_of GO:0007498 ! mesoderm development

[Term]
id: GO:0048384
name: retinoic acid receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands." [GOC:dgh]
synonym: "RAR signaling pathway" EXACT []
synonym: "retinoic acid receptor signalling pathway" EXACT []
is_a: GO:0030522 ! intracellular receptor signaling pathway

[Term]
id: GO:0048385
name: regulation of retinoic acid receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of retinoic acid receptor signaling pathway activity." [GOC:dgh]
synonym: "regulation of RAR signaling pathway" EXACT []
synonym: "regulation of retinoic acid receptor signalling pathway" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048384 ! retinoic acid receptor signaling pathway
relationship: regulates GO:0048384 ! retinoic acid receptor signaling pathway

[Term]
id: GO:0048386
name: positive regulation of retinoic acid receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of retinoic acid receptor signaling pathway activity." [GOC:dgh]
synonym: "activation of retinoic acid receptor signaling pathway" NARROW []
synonym: "positive regulation of RAR signaling pathway" EXACT []
synonym: "positive regulation of retinoic acid receptor signalling pathway" EXACT []
synonym: "stimulation of retinoic acid receptor signaling pathway" NARROW []
synonym: "up regulation of retinoic acid receptor signaling pathway" EXACT []
synonym: "up-regulation of retinoic acid receptor signaling pathway" EXACT []
synonym: "upregulation of retinoic acid receptor signaling pathway" EXACT []
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0048385 ! regulation of retinoic acid receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048384 ! retinoic acid receptor signaling pathway
relationship: positively_regulates GO:0048384 ! retinoic acid receptor signaling pathway

[Term]
id: GO:0048387
name: negative regulation of retinoic acid receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of retinoic acid receptor signaling pathway activity." [GOC:dgh]
synonym: "down regulation of retinoic acid receptor signaling pathway" EXACT []
synonym: "down-regulation of retinoic acid receptor signaling pathway" EXACT []
synonym: "downregulation of retinoic acid receptor signaling pathway" EXACT []
synonym: "inhibition of retinoic acid receptor signaling pathway" NARROW []
synonym: "negative regulation of RAR signaling pathway" EXACT []
synonym: "negative regulation of RAR signalling pathway" EXACT []
synonym: "negative regulation of retinoic acid receptor signalling pathway" EXACT []
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0048385 ! regulation of retinoic acid receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048384 ! retinoic acid receptor signaling pathway
relationship: negatively_regulates GO:0048384 ! retinoic acid receptor signaling pathway

[Term]
id: GO:0048388
name: endosomal lumen acidification
namespace: biological_process
def: "Any process that reduces the pH of the endosomal lumen, measured by the concentration of the hydrogen ion." [GOC:jid]
is_a: GO:0051452 ! intracellular pH reduction
relationship: part_of GO:0007032 ! endosome organization

[Term]
id: GO:0048389
name: intermediate mesoderm development
namespace: biological_process
def: "The process whose specific outcome is the progression of the intermediate mesoderm over time, from its formation to the mature structure. The intermediate mesoderm is located between the lateral mesoderm and the paraxial mesoderm. It develops into the kidney and gonads." [GOC:dgh]
is_a: GO:0007498 ! mesoderm development

[Term]
id: GO:0048390
name: intermediate mesoderm morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the intermediate mesoderm are generated and organized." [GOC:go_curators]
is_a: GO:0048332 ! mesoderm morphogenesis
relationship: part_of GO:0048389 ! intermediate mesoderm development

[Term]
id: GO:0048391
name: intermediate mesoderm formation
namespace: biological_process
def: "The process that gives rise to the intermediate mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:dgh]
is_a: GO:0001707 ! mesoderm formation
relationship: part_of GO:0048390 ! intermediate mesoderm morphogenesis

[Term]
id: GO:0048392
name: intermediate mesodermal cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an intermediate mesoderm cell." [GOC:dgh]
synonym: "intermediate mesoderm cell differentiation" EXACT []
is_a: GO:0048333 ! mesodermal cell differentiation
relationship: part_of GO:0048391 ! intermediate mesoderm formation

[Term]
id: GO:0048393
name: intermediate mesodermal cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into an intermediate mesoderm cell." [GOC:dgh]
synonym: "intermediate mesoderm cell fate commitment" EXACT []
is_a: GO:0001710 ! mesodermal cell fate commitment
relationship: part_of GO:0048392 ! intermediate mesodermal cell differentiation

[Term]
id: GO:0048394
name: intermediate mesodermal cell fate determination
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a intermediate mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:dgh]
synonym: "intermediate mesoderm cell fate determination" EXACT []
is_a: GO:0007500 ! mesodermal cell fate determination
relationship: part_of GO:0048393 ! intermediate mesodermal cell fate commitment

[Term]
id: GO:0048395
name: regulation of intermediate mesodermal cell fate determination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of intermediate mesoderm cell fate determination." [GOC:dgh]
is_a: GO:0048334 ! regulation of mesodermal cell fate determination
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048394 ! intermediate mesodermal cell fate determination
relationship: regulates GO:0048394 ! intermediate mesodermal cell fate determination

[Term]
id: GO:0048396
name: negative regulation of intermediate mesodermal cell fate determination
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of intermediate mesoderm cell fate determination." [GOC:dgh]
synonym: "down regulation of intermediate mesodermal cell fate determination" EXACT []
synonym: "down-regulation of intermediate mesodermal cell fate determination" EXACT []
synonym: "downregulation of intermediate mesodermal cell fate determination" EXACT []
synonym: "inhibition of intermediate mesodermal cell fate determination" NARROW []
is_a: GO:0048335 ! negative regulation of mesodermal cell fate determination
is_a: GO:0048395 ! regulation of intermediate mesodermal cell fate determination
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048394 ! intermediate mesodermal cell fate determination
relationship: negatively_regulates GO:0048394 ! intermediate mesodermal cell fate determination

[Term]
id: GO:0048397
name: positive regulation of intermediate mesodermal cell fate determination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of intermediate mesoderm cell fate determination." [GOC:dgh]
synonym: "activation of intermediate mesodermal cell fate determination" NARROW []
synonym: "stimulation of intermediate mesodermal cell fate determination" NARROW []
synonym: "up regulation of intermediate mesodermal cell fate determination" EXACT []
synonym: "up-regulation of intermediate mesodermal cell fate determination" EXACT []
synonym: "upregulation of intermediate mesodermal cell fate determination" EXACT []
is_a: GO:0048336 ! positive regulation of mesodermal cell fate determination
is_a: GO:0048395 ! regulation of intermediate mesodermal cell fate determination
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048394 ! intermediate mesodermal cell fate determination
relationship: positively_regulates GO:0048394 ! intermediate mesodermal cell fate determination

[Term]
id: GO:0048398
name: intermediate mesodermal cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into an intermediate mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:dgh]
synonym: "intermediate mesoderm cell fate specification" EXACT []
is_a: GO:0007501 ! mesodermal cell fate specification
relationship: part_of GO:0048393 ! intermediate mesodermal cell fate commitment

[Term]
id: GO:0048399
name: regulation of intermediate mesodermal cell fate specification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of intermediate mesoderm cell fate specification." [GOC:dgh]
is_a: GO:0042661 ! regulation of mesodermal cell fate specification
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048398 ! intermediate mesodermal cell fate specification
relationship: regulates GO:0048398 ! intermediate mesodermal cell fate specification

[Term]
id: GO:0048400
name: positive regulation of intermediate mesodermal cell fate specification
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of intermediate mesoderm cell fate specification." [GOC:dgh]
synonym: "activation of intermediate mesodermal cell fate specification" NARROW []
synonym: "stimulation of intermediate mesodermal cell fate specification" NARROW []
synonym: "up regulation of intermediate mesodermal cell fate specification" EXACT []
synonym: "up-regulation of intermediate mesodermal cell fate specification" EXACT []
synonym: "upregulation of intermediate mesodermal cell fate specification" EXACT []
is_a: GO:0048337 ! positive regulation of mesodermal cell fate specification
is_a: GO:0048399 ! regulation of intermediate mesodermal cell fate specification
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048398 ! intermediate mesodermal cell fate specification
relationship: positively_regulates GO:0048398 ! intermediate mesodermal cell fate specification

[Term]
id: GO:0048401
name: negative regulation of intermediate mesodermal cell fate specification
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of intermediate mesoderm cell fate specification." [GOC:dgh]
synonym: "down regulation of intermediate mesodermal cell fate specification" EXACT []
synonym: "down-regulation of intermediate mesodermal cell fate specification" EXACT []
synonym: "downregulation of intermediate mesodermal cell fate specification" EXACT []
synonym: "inhibition of intermediate mesodermal cell fate specification" NARROW []
is_a: GO:0042662 ! negative regulation of mesodermal cell fate specification
is_a: GO:0048399 ! regulation of intermediate mesodermal cell fate specification
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048398 ! intermediate mesodermal cell fate specification
relationship: negatively_regulates GO:0048398 ! intermediate mesodermal cell fate specification

[Term]
id: GO:0048402
name: intermediate mesoderm structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the intermediate mesoderm. This process pertains to the physical shaping of a rudimentary structure." [GOC:dgh]
synonym: "intermediate mesoderm structural organisation" EXACT [GOC:curators]
is_a: GO:0048338 ! mesoderm structural organization
relationship: part_of GO:0048390 ! intermediate mesoderm morphogenesis

[Term]
id: GO:0048403
name: brain-derived neurotrophic factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with brain-derived neurotrophic factor." [GOC:dgh]
synonym: "BDNF binding" EXACT []
synonym: "neurotrophin TRKB receptor activity" RELATED []
is_a: GO:0043121 ! neurotrophin binding

[Term]
id: GO:0048406
name: nerve growth factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with nerve growth factor (NGF)." [GOC:dgh]
synonym: "beta-nerve growth factor binding" EXACT [PR:000011194]
synonym: "neurotrophin TRKA receptor activity" RELATED []
synonym: "NGF binding" EXACT [PR:000011194]
is_a: GO:0043121 ! neurotrophin binding

[Term]
id: GO:0048407
name: platelet-derived growth factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with platelet-derived growth factor." [GOC:dgh]
synonym: "PDGF binding" EXACT []
is_a: GO:0019838 ! growth factor binding

[Term]
id: GO:0048408
name: epidermal growth factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with epidermal growth factor." [GOC:dgh]
synonym: "EGF binding" EXACT []
is_a: GO:0019838 ! growth factor binding
is_a: GO:0042562 ! hormone binding

[Term]
id: GO:0048437
name: floral organ development
namespace: biological_process
alt_id: GO:0048433
def: "The process whose specific outcome is the progression of the floral organ over time, from its formation to the mature structure." [GOC:go_curators, GOC:PO_curators, PO:0025395]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0099402 ! plant organ development
relationship: part_of GO:0009908 ! flower development

[Term]
id: GO:0048438
name: floral whorl development
namespace: biological_process
alt_id: GO:0048413
def: "The process whose specific outcome is the progression of a floral whorl over time, from its formation to the mature structure. A floral whorl is a circular arrangement of parts of a flower arising from a stem of a plant." [GOC:dph, GOC:go_curators, GOC:PO_curators, GOC:tb, PO:0025023]
comment: Consider instead annotating to one of the more specific child terms, or to 'floral organ development ; GO:0048438' or one of its child terms.
synonym: "collective phyllome structure development" BROAD [GOC:PO_curators, PO:0025023]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0009908 ! flower development

[Term]
id: GO:0048439
name: flower morphogenesis
namespace: biological_process
alt_id: GO:0048411
def: "The process in which the anatomical structures of the flower are generated and organized." [GOC:go_curators]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0009886 ! post-embryonic morphogenesis
is_a: GO:0010016 ! shoot system morphogenesis
relationship: part_of GO:0009908 ! flower development

[Term]
id: GO:0048440
name: carpel development
namespace: biological_process
alt_id: GO:0048429
def: "The process whose specific outcome is the progression of the carpel over time, from its formation to the mature structure. A carpel is an organ (generally believed to be a modified foliar unit) at the centre of a flower, bearing one or more ovules and having its margins fused together or with other carpels to enclose the ovule in an ovary, and consisting also of a stigma and usually a style." [GOC:go_curators]
is_a: GO:0048437 ! floral organ development
is_a: GO:0048827 ! phyllome development
relationship: part_of GO:0048467 ! gynoecium development

[Term]
id: GO:0048441
name: petal development
namespace: biological_process
alt_id: GO:0048417
def: "The process whose specific outcome is the progression of the petal over time, from its formation to the mature structure." [GOC:go_curators]
is_a: GO:0048437 ! floral organ development
is_a: GO:0048827 ! phyllome development
relationship: part_of GO:0048465 ! corolla development

[Term]
id: GO:0048442
name: sepal development
namespace: biological_process
alt_id: GO:0048421
def: "The process whose specific outcome is the progression of the sepal over time, from its formation to the mature structure." [GOC:go_curators]
is_a: GO:0048437 ! floral organ development
is_a: GO:0048827 ! phyllome development
relationship: part_of GO:0048464 ! flower calyx development

[Term]
id: GO:0048443
name: stamen development
namespace: biological_process
alt_id: GO:0048425
def: "The process whose specific outcome is the progression of the stamen over time, from its formation to the mature structure." [GOC:go_curators]
is_a: GO:0048437 ! floral organ development
is_a: GO:0048827 ! phyllome development
relationship: part_of GO:0048466 ! androecium development

[Term]
id: GO:0048444
name: floral organ morphogenesis
namespace: biological_process
alt_id: GO:0048434
def: "The process in which the anatomical structures of the floral organ are generated and organized." [GOC:go_curators, GOC:PO_curators, PO:0025395]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0048563 ! post-embryonic organ morphogenesis
relationship: part_of GO:0048437 ! floral organ development

[Term]
id: GO:0048445
name: carpel morphogenesis
namespace: biological_process
alt_id: GO:0048430
def: "The process in which the anatomical structures of the carpel are generated and organized." [GOC:go_curators]
is_a: GO:0048444 ! floral organ morphogenesis
relationship: part_of GO:0048440 ! carpel development

[Term]
id: GO:0048446
name: petal morphogenesis
namespace: biological_process
alt_id: GO:0048418
def: "The process in which the anatomical structures of the petal are generated and organized." [GOC:go_curators]
is_a: GO:0048444 ! floral organ morphogenesis
relationship: part_of GO:0048441 ! petal development

[Term]
id: GO:0048447
name: sepal morphogenesis
namespace: biological_process
alt_id: GO:0048422
def: "The process in which the anatomical structures of the sepal are generated and organized." [GOC:go_curators]
is_a: GO:0048444 ! floral organ morphogenesis
relationship: part_of GO:0048442 ! sepal development

[Term]
id: GO:0048448
name: stamen morphogenesis
namespace: biological_process
alt_id: GO:0048426
def: "The process in which the anatomical structures of the stamen are generated and organized." [GOC:go_curators]
is_a: GO:0048444 ! floral organ morphogenesis
relationship: part_of GO:0048443 ! stamen development

[Term]
id: GO:0048449
name: floral organ formation
namespace: biological_process
alt_id: GO:0048436
def: "The process that gives rise to floral organs. This process pertains to the initial formation of a structure from unspecified parts." [GOC:jid, GOC:PO_curators, PO:0025395]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0048444 ! floral organ morphogenesis

[Term]
id: GO:0048450
name: floral organ structural organization
namespace: biological_process
alt_id: GO:0048435
def: "The process that contributes to the act of creating the structural organization of floral organs. This process pertains to the physical shaping of a rudimentary structure." [GOC:jid, GOC:PO_curators, PO:0025395]
synonym: "floral organ structural organisation" EXACT [GOC:curators]
is_a: GO:0048444 ! floral organ morphogenesis
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0048461 ! flower structural organization

[Term]
id: GO:0048451
name: petal formation
namespace: biological_process
alt_id: GO:0048419
def: "The process that gives rise to the petal. This process pertains to the initial formation of a structure from unspecified parts." [GOC:jid]
is_a: GO:0048449 ! floral organ formation
relationship: part_of GO:0048446 ! petal morphogenesis

[Term]
id: GO:0048452
name: petal structural organization
namespace: biological_process
alt_id: GO:0048420
def: "The process that contributes to the act of creating the structural organization of the petal. This process pertains to the physical shaping of a rudimentary structure." [GOC:jid]
synonym: "petal structural organisation" EXACT [GOC:curators]
is_a: GO:0048450 ! floral organ structural organization
relationship: part_of GO:0048446 ! petal morphogenesis

[Term]
id: GO:0048453
name: sepal formation
namespace: biological_process
alt_id: GO:0048423
def: "The process that gives rise to the sepal. This process pertains to the initial formation of a structure from unspecified parts." [GOC:jid]
is_a: GO:0048449 ! floral organ formation
relationship: part_of GO:0048447 ! sepal morphogenesis

[Term]
id: GO:0048454
name: sepal structural organization
namespace: biological_process
alt_id: GO:0048424
def: "The process that contributes to the act of creating the structural organization of the sepal. This process pertains to the physical shaping of a rudimentary structure." [GOC:jid]
synonym: "sepal structural organisation" EXACT [GOC:curators]
is_a: GO:0048450 ! floral organ structural organization
relationship: part_of GO:0048447 ! sepal morphogenesis

[Term]
id: GO:0048455
name: stamen formation
namespace: biological_process
alt_id: GO:0048427
def: "The process that contributes to the act of giving rise to the stamen. This process pertains to the initial formation of a structure from unspecified parts." [GOC:jid]
is_a: GO:0048449 ! floral organ formation
relationship: part_of GO:0048448 ! stamen morphogenesis

[Term]
id: GO:0048456
name: stamen structural organization
namespace: biological_process
alt_id: GO:0048428
def: "The process that contributes to the act of creating the structural organization of the stamen. This process pertains to the physical shaping of a rudimentary structure." [GOC:jid]
synonym: "stamen structural organisation" EXACT [GOC:curators]
is_a: GO:0048450 ! floral organ structural organization
relationship: part_of GO:0048448 ! stamen morphogenesis

[Term]
id: GO:0048457
name: floral whorl morphogenesis
namespace: biological_process
alt_id: GO:0048414
def: "The process in which the anatomical structures of the floral whorl are generated and organized." [GOC:go_curators, GOC:PO_curators, PO:0025023]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0009886 ! post-embryonic morphogenesis
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0048438 ! floral whorl development
relationship: part_of GO:0048439 ! flower morphogenesis

[Term]
id: GO:0048458
name: floral whorl formation
namespace: biological_process
alt_id: GO:0048415
def: "The process that gives rise to the floral whorl. This process pertains to the initial formation of a structure from unspecified parts." [GOC:jid, GOC:PO_curators, PO:0025023]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0048457 ! floral whorl morphogenesis

[Term]
id: GO:0048459
name: floral whorl structural organization
namespace: biological_process
alt_id: GO:0048416
def: "The process that contributes to the act of creating the structural organization of the floral whorl. This process pertains to the physical shaping of a rudimentary structure." [GOC:jid, GOC:PO_curators, PO:0025023]
synonym: "floral whorl structural organisation" EXACT [GOC:curators]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0048457 ! floral whorl morphogenesis
relationship: part_of GO:0048461 ! flower structural organization

[Term]
id: GO:0048460
name: flower formation
namespace: biological_process
alt_id: GO:0048410
def: "The process that gives rise to the flower. This process pertains to the initial formation of a structure from unspecified parts." [GOC:jid]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0048439 ! flower morphogenesis

[Term]
id: GO:0048461
name: flower structural organization
namespace: biological_process
alt_id: GO:0048412
def: "The process that contributes to the act of creating the structural organization of the flower. This process pertains to the physical shaping of a rudimentary structure." [GOC:jid]
synonym: "flower structural organisation" EXACT [GOC:curators]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0048439 ! flower morphogenesis

[Term]
id: GO:0048462
name: carpel formation
namespace: biological_process
alt_id: GO:0048431
def: "The process that gives rise to the carpel. This process pertains to the initial formation of a structure from unspecified parts." [GOC:jid]
is_a: GO:0048449 ! floral organ formation
relationship: part_of GO:0048445 ! carpel morphogenesis

[Term]
id: GO:0048463
name: carpel structural organization
namespace: biological_process
alt_id: GO:0048432
def: "The process that contributes to the act of creating the structural organization of the carpel. This process pertains to the physical shaping of a rudimentary structure." [GOC:jid]
synonym: "carpel structural organisation" EXACT [GOC:curators]
is_a: GO:0048450 ! floral organ structural organization
relationship: part_of GO:0048445 ! carpel morphogenesis

[Term]
id: GO:0048464
name: flower calyx development
namespace: biological_process
def: "The process whose specific outcome is the progression of the flower calyx over time, from its formation to the mature structure." [GOC:go_curators]
is_a: GO:0048438 ! floral whorl development

[Term]
id: GO:0048465
name: corolla development
namespace: biological_process
def: "The process whose specific outcome is the progression of the corolla over time, from its formation to the mature structure." [GOC:go_curators]
is_a: GO:0048438 ! floral whorl development

[Term]
id: GO:0048466
name: androecium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the androecium over time, from its formation to the mature structure." [GOC:go_curators]
is_a: GO:0048438 ! floral whorl development

[Term]
id: GO:0048467
name: gynoecium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the gynoecium over time, from its formation to the mature structure. The gynoecium is the collective name for the carpels of a flower." [GOC:go_curators, PO:0008062]
synonym: "pistil development" EXACT []
is_a: GO:0048438 ! floral whorl development

[Term]
id: GO:0048468
name: cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:go_curators]
subset: goslim_candida
subset: gosubset_prok
synonym: "terminal differentiation" RELATED [GOC:dph, GOC:tb]
is_a: GO:0048856 ! anatomical structure development
is_a: GO:0048869 ! cellular developmental process
relationship: part_of GO:0030154 ! cell differentiation

[Term]
id: GO:0048469
name: cell maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a cell to attain its fully functional state." [GOC:go_curators]
subset: goslim_pir
subset: gosubset_prok
synonym: "functional differentiation" RELATED [GOC:dph]
is_a: GO:0021700 ! developmental maturation
is_a: GO:0048869 ! cellular developmental process
relationship: part_of GO:0048468 ! cell development

[Term]
id: GO:0048471
name: perinuclear region of cytoplasm
namespace: cellular_component
def: "Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]
comment: Note that this term should not be confused with the cellular component term 'nuclear membrane lumen ; GO:0005641', which has the synonym 'perinuclear space'.
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0048472
name: threonine-phosphate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: O-phospho-L-threonine + H(+) = (R)-1-aminopropan-2-yl phosphate + CO(2)." [EC:4.1.1.81, RHEA:11495]
subset: gosubset_prok
synonym: "CobD" RELATED [EC:4.1.1.81]
synonym: "L-threonine O-3-phosphate carboxy-lyase [(R)-1-aminopropan-2-yl-phosphate-forming]" RELATED [EC:4.1.1.81]
synonym: "L-threonine O-3-phosphate carboxy-lyase activity" EXACT [EC:4.1.1.81]
synonym: "L-threonine-O-3-phosphate decarboxylase activity" EXACT []
xref: EC:4.1.1.81
xref: KEGG:R06530
xref: MetaCyc:4.1.1.81-RXN
xref: RHEA:11495
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0048473
name: D-methionine transport
namespace: biological_process
def: "The directed movement of D-methionine into, out of, within, or between cells." [GOC:mlg, PMID:12169620]
subset: gosubset_prok
is_a: GO:0015821 ! methionine transport
is_a: GO:0042940 ! D-amino acid transport

[Term]
id: GO:0048474
name: D-methionine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of D-methionine from one side of a membrane to the other." [GOC:mlg, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "D-methionine transporter activity" BROAD []
is_a: GO:0042943 ! D-amino acid transmembrane transporter activity
is_a: GO:0043865 ! methionine transmembrane transporter activity
relationship: part_of GO:0048473 ! D-methionine transport

[Term]
id: GO:0048475
name: coated membrane
namespace: cellular_component
def: "A single or double lipid bilayer with any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes." [GOC:jid]
is_a: GO:0016020 ! membrane

[Term]
id: GO:0048476
name: Holliday junction resolvase complex
namespace: cellular_component
def: "A protein complex that mediates the conversion of a Holliday junction into two separate duplex DNA molecules; the complex includes a single- or multisubunit helicase that catalyzes the extension of heteroduplex DNA by branch migration and a nuclease that resolves the junction by nucleolytic cleavage." [PMID:11207366, PMID:12374758]
subset: goslim_pir
synonym: "Mus81-Eme1 complex" NARROW []
synonym: "resolvasome" EXACT [PMID:11207366]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0048477
name: oogenesis
namespace: biological_process
alt_id: GO:0009993
alt_id: GO:0048157
def: "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
synonym: "ovum development" EXACT systematic_synonym []
xref: Wikipedia:Oogenesis
is_a: GO:0007281 ! germ cell development
is_a: GO:0007292 ! female gamete generation

[Term]
id: GO:0048478
name: replication fork protection
namespace: biological_process
def: "Any process that prevents the collapse of stalled replication forks." [GOC:vw, PMID:14560029]
synonym: "replication fork maintenance" BROAD []
synonym: "replication fork stabilization" BROAD []
is_a: GO:0045005 ! DNA-dependent DNA replication maintenance of fidelity
is_a: GO:2000104 ! negative regulation of DNA-dependent DNA replication

[Term]
id: GO:0048479
name: style development
namespace: biological_process
def: "The process whose specific outcome is the progression of the style over time, from its formation to the mature structure. The style is an elongated part of a carpel, or group of fused carpels, and it lies between the ovary and the stigma." [GOC:jid, PO:0009074]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048440 ! carpel development

[Term]
id: GO:0048480
name: stigma development
namespace: biological_process
def: "The process whose specific outcome is the progression of the stigma over time, from its formation to the mature structure. The stigma is the pollen-receptive surface of a carpel or group of fused carpels, usually sticky." [GOC:jid, PO:0009073]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048440 ! carpel development

[Term]
id: GO:0048481
name: plant ovule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the ovule over time, from its formation to the mature structure. The ovule is the structure in seed plants enclosing the female gametophyte, and is composed of the nucellus, one or two integuments, and the funiculus; it develops into the seed." [GOC:tb]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0099402 ! plant organ development
relationship: part_of GO:0035670 ! plant-type ovary development

[Term]
id: GO:0048482
name: plant ovule morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the ovule are generated and organized. The ovule is the structure in seed plants enclosing the female gametophyte, and is composed of the nucellus, one or two integuments, and the funiculus; it develops into the seed." [GOC:tb]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0009886 ! post-embryonic morphogenesis
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0048445 ! carpel morphogenesis
relationship: part_of GO:0048481 ! plant ovule development

[Term]
id: GO:0048483
name: autonomic nervous system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the autonomic nervous system over time, from its formation to the mature structure. The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands." [FMA:9905, GOC:jid, GOC:sr]
is_a: GO:0048731 ! system development
relationship: part_of GO:0007399 ! nervous system development

[Term]
id: GO:0048484
name: enteric nervous system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the enteric nervous system over time, from its formation to the mature structure. The enteric nervous system is composed of two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gall bladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation." [FMA:66070, GOC:jid, GOC:sr]
is_a: GO:0048731 ! system development
relationship: part_of GO:0048483 ! autonomic nervous system development

[Term]
id: GO:0048485
name: sympathetic nervous system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the sympathetic nervous system over time, from its formation to the mature structure. The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter." [FMA:9906, GOC:jid, GOC:sr]
is_a: GO:0048731 ! system development
relationship: part_of GO:0048483 ! autonomic nervous system development

[Term]
id: GO:0048486
name: parasympathetic nervous system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the parasympathetic nervous system over time, from its formation to the mature structure. The parasympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia." [FMA:9907, GOC:jid, GOC:sr]
is_a: GO:0048731 ! system development
relationship: part_of GO:0048483 ! autonomic nervous system development

[Term]
id: GO:0048487
name: beta-tubulin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the microtubule constituent protein beta-tubulin." [GOC:krc]
synonym: "beta tubulin binding" EXACT []
is_a: GO:0015631 ! tubulin binding

[Term]
id: GO:0048488
name: synaptic vesicle endocytosis
namespace: biological_process
alt_id: GO:0008099
def: "Clathrin-mediated endocytosis of presynaptic membrane that recycles synaptic vesicle membrane and its components following synaptic vesicle exocytosis. This process starts with coating of the membrane with adaptor proteins and clathrin prior to invagination and ends when uncoating has finished." [GOC:jid, GOC:lmg, GOC:mah, PMID:20448150]
subset: goslim_synapse
subset: gosubset_prok
synonym: "synaptic vesicle retrieval" RELATED []
is_a: GO:0016482 ! cytosolic transport
is_a: GO:0072583 ! clathrin-mediated endocytosis
relationship: part_of GO:0036465 ! synaptic vesicle recycling

[Term]
id: GO:0048489
name: synaptic vesicle transport
namespace: biological_process
alt_id: GO:0016181
def: "The directed movement of synaptic vesicles." [GOC:jid, GOC:lmg, GOC:pr]
subset: gosubset_prok
synonym: "synaptic vesicle fission" RELATED []
synonym: "synaptic vesicle fusion" RELATED []
synonym: "synaptic vesicle trafficking" RELATED [PMID:15217342]
is_a: GO:0016192 ! vesicle-mediated transport
is_a: GO:0016482 ! cytosolic transport
is_a: GO:0097479 ! synaptic vesicle localization
is_a: GO:0097480 ! establishment of synaptic vesicle localization
is_a: GO:1902580 ! single-organism cellular localization
is_a: GO:1902582 ! single-organism intracellular transport
relationship: occurs_in GO:0005829 ! cytosol

[Term]
id: GO:0048490
name: anterograde synaptic vesicle transport
namespace: biological_process
def: "The directed movement of synaptic vesicle along axonal microtubules from the cell body to the presynapse." [GOC:jid, GOC:lmg]
subset: goslim_synapse
synonym: "anterograde axonal transport of synaptic vesicle" EXACT []
is_a: GO:0008089 ! anterograde axonal transport
is_a: GO:0099517 ! synaptic vesicle transport along microtubule
relationship: occurs_in GO:1904115 ! axon cytoplasm

[Term]
id: GO:0048491
name: retrograde synaptic vesicle transport
namespace: biological_process
def: "The directed movement of synaptic vesicle along axonal microtubules from the presynapse to the cell body." [GOC:jid, GOC:lmg, PMID:24762653]
subset: goslim_synapse
synonym: "retrograde axonal transport of synaptic vesicle" EXACT []
is_a: GO:0008090 ! retrograde axonal transport
is_a: GO:0099517 ! synaptic vesicle transport along microtubule
relationship: occurs_in GO:1904115 ! axon cytoplasm

[Term]
id: GO:0048492
name: ribulose bisphosphate carboxylase complex
namespace: cellular_component
def: "A complex containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate." [GOC:mlg]
subset: goslim_pir
subset: gosubset_prok
synonym: "RubisCO complex" EXACT []
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:1902494 ! catalytic complex

[Term]
id: GO:0048493
name: plasma membrane-derived thylakoid ribulose bisphosphate carboxylase complex
namespace: cellular_component
def: "A complex, located in the plasma membrane-derived thylakoid, containing either both large and small subunits or just small subunits. It carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate." [GOC:mlg, GOC:mtg_sensu]
subset: gosubset_prok
synonym: "plasma membrane ribulose bisphosphate carboxylase complex" EXACT []
synonym: "ribulose bisphosphate carboxylase complex" BROAD []
synonym: "RubisCO complex" BROAD []
is_a: GO:0044422 ! organelle part
is_a: GO:0044436 ! thylakoid part
is_a: GO:0048494 ! chromatophore ribulose bisphosphate carboxylase complex
is_a: GO:0098797 ! plasma membrane protein complex
intersection_of: GO:0048492 ! ribulose bisphosphate carboxylase complex
intersection_of: part_of GO:0030075 ! bacterial thylakoid
relationship: part_of GO:0030075 ! bacterial thylakoid

[Term]
id: GO:0048494
name: chromatophore ribulose bisphosphate carboxylase complex
namespace: cellular_component
def: "A complex, located in the chromatophore, containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate." [GOC:mlg, GOC:mtg_sensu]
subset: gosubset_prok
synonym: "RubisCO complex" BROAD []
is_a: GO:0048492 ! ribulose bisphosphate carboxylase complex
intersection_of: GO:0048492 ! ribulose bisphosphate carboxylase complex
intersection_of: part_of GO:0042716 ! plasma membrane-derived chromatophore
relationship: part_of GO:0042716 ! plasma membrane-derived chromatophore

[Term]
id: GO:0048495
name: Roundabout binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the Roundabout (ROBO) receptor, a transmembrane receptor." [GOC:ecd, PMID:10102268, PMID:10197527]
synonym: "Roundabout receptor binding" RELATED []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0048496
name: maintenance of organ identity
namespace: biological_process
def: "The process in which the identity of an organ is maintained. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tair_curators, PMID:9090883]
is_a: GO:0045596 ! negative regulation of cell differentiation
relationship: part_of GO:0048513 ! animal organ development

[Term]
id: GO:0048497
name: maintenance of floral organ identity
namespace: biological_process
def: "The process in which the identity of a floral organ is maintained. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:PO_curators, GOC:tair_curators, PMID:9090883, PO:0025395]
is_a: GO:0022414 ! reproductive process
is_a: GO:0048496 ! maintenance of organ identity
relationship: part_of GO:0048437 ! floral organ development

[Term]
id: GO:0048498
name: establishment of petal orientation
namespace: biological_process
def: "The process that determines the orientation of petals with reference to the central axis." [GOC:tb, PMID:10572040]
is_a: GO:0048559 ! establishment of floral organ orientation
relationship: part_of GO:0048446 ! petal morphogenesis

[Term]
id: GO:0048499
name: synaptic vesicle membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the membrane surrounding a synaptic vesicle." [GOC:dph, GOC:jl, GOC:mah, PMID:10620806]
synonym: "SLMV biogenesis" NARROW []
synonym: "synaptic vesicle membrane organisation" EXACT [GOC:curators]
synonym: "synaptic vesicle membrane organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0044802 ! single-organism membrane organization
relationship: part_of GO:0010256 ! endomembrane system organization

[Term]
id: GO:0048500
name: signal recognition particle
namespace: cellular_component
def: "A complex of protein and RNA which facilitates translocation of proteins across membranes." [GOC:mlg]
subset: goslim_pir
subset: gosubset_prok
xref: Wikipedia:Signal_recognition_particle
is_a: GO:0030529 ! intracellular ribonucleoprotein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0048501
name: signal recognition particle, plasma membrane targeting
namespace: cellular_component
def: "A complex consisting of a protein and RNA component which binds the signal sequence of some proteins and facilitates their export to or across the plasma membrane." [GOC:mlg, GOC:mtg_sensu]
subset: gosubset_prok
is_a: GO:0048500 ! signal recognition particle

[Term]
id: GO:0048502
name: thiamine-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O + thiamine(out) = ADP + phosphate + thiamine(in)." [GOC:mlg, PMID:9535878]
synonym: "thiamin-transporting ATPase activity" EXACT [GOC:curators]
synonym: "thiamine ABC transporter" NARROW []
xref: RHEA:29814
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances

[Term]
id: GO:0048503
name: obsolete GPI anchor binding
namespace: molecular_function
def: "OBSOLETE. Interacting selectively with any glycosylphosphatidylinositol anchor. GPI anchors serve to attach membrane proteins to the lipid bilayer of cell membranes." [GOC:vw]
comment: This term was made obsolete because it has been widely, and incorrectly, used to annotate proteins that have GPI anchors covalently attached. A new term has been created that can be used to annotate gene products that interact non-covalently with GPI anchors.
synonym: "glycosylphosphatidylinositol binding" EXACT []
synonym: "GPI anchor binding" EXACT []
is_obsolete: true

[Term]
id: GO:0048504
name: regulation of timing of organ formation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of organ formation at a consistent predetermined time point during development." [GOC:bf, GOC:dph, GOC:jid, GOC:tb]
synonym: "timing of organ biosynthesis" RELATED []
synonym: "timing of organ formation" RELATED []
is_a: GO:0003156 ! regulation of organ formation
is_a: GO:0040034 ! regulation of development, heterochronic

[Term]
id: GO:0048505
name: regulation of timing of cell differentiation
namespace: biological_process
def: "The process controlling the activation and/or rate at which relatively unspecialized cells acquire specialized features. Any process that modulates the rate, frequency or extent of the XXX at a consistent predetermined time point during its development." [GOC:bf, GOC:dph, GOC:jid, GOC:tb]
synonym: "timing of cell differentiation" RELATED []
is_a: GO:0040034 ! regulation of development, heterochronic
is_a: GO:0045595 ! regulation of cell differentiation

[Term]
id: GO:0048506
name: regulation of timing of meristematic phase transition
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of a change in identity of a meristem at a characteristic predetermined time point." [GOC:dph, GOC:jid, GOC:tb]
is_a: GO:0040034 ! regulation of development, heterochronic
is_a: GO:0048509 ! regulation of meristem development

[Term]
id: GO:0048507
name: meristem development
namespace: biological_process
def: "The process whose specific outcome is the progression of the meristem over time, from its formation to the mature structure." [GOC:jid]
is_a: GO:0009888 ! tissue development

[Term]
id: GO:0048508
name: embryonic meristem development
namespace: biological_process
def: "The process whose specific outcome is the progression of the embryonic meristem over time, from its formation to the mature structure." [GOC:jid]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048507 ! meristem development
relationship: part_of GO:0009793 ! embryo development ending in seed dormancy

[Term]
id: GO:0048509
name: regulation of meristem development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of meristem development, the biological process whose specific outcome is the progression of the meristem over time, from its formation to the mature structure." [GOC:jid]
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048507 ! meristem development
relationship: regulates GO:0048507 ! meristem development

[Term]
id: GO:0048510
name: regulation of timing of transition from vegetative to reproductive phase
namespace: biological_process
def: "The process controlling the point in time during development when a vegetative meristem will change its identity to become an inflorescence or floral meristem, and/or the rate at which the change occurs." [GOC:jid, PMID:8974397]
is_a: GO:0048506 ! regulation of timing of meristematic phase transition

[Term]
id: GO:0048511
name: rhythmic process
namespace: biological_process
def: "Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism." [GOC:jid]
subset: goslim_pir
subset: gosubset_prok
synonym: "rhythm" RELATED []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0048512
name: circadian behavior
namespace: biological_process
def: "The specific behavior of an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators, GOC:pr]
synonym: "circadian rhythm behavior" EXACT []
is_a: GO:0007622 ! rhythmic behavior
is_a: GO:0007623 ! circadian rhythm

[Term]
id: GO:0048513
name: animal organ development
namespace: biological_process
def: "Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]
synonym: "development of an organ" EXACT []
synonym: "organogenesis" EXACT []
xref: Wikipedia:Organogenesis
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048731 ! system development

[Term]
id: GO:0048514
name: blood vessel morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood." [GOC:jid]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0001568 ! blood vessel development

[Term]
id: GO:0048515
name: spermatid differentiation
namespace: biological_process
def: "The process whose specific outcome is the progression of a spermatid over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:jid]
synonym: "spermatid cell differentiation" EXACT []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0007283 ! spermatogenesis

[Term]
id: GO:0048516
name: obsolete trichome initiation (sensu Magnoliophyta)
namespace: biological_process
def: "OBSOLETE. Processes causing the differentiation of an epidermal cell into a trichome cell; as in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398)." [GOC:lr]
comment: This term was made obsolete because more appropriate terms were created.
synonym: "trichome initiation (sensu Magnoliophyta)" EXACT []
is_obsolete: true
consider: GO:0048629

[Term]
id: GO:0048517
name: obsolete positive regulation of trichome initiation (sensu Magnoliophyta)
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of trichome initiation; as in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398)." [GOC:lr]
comment: This term was made obsolete because more appropriate terms were created.
synonym: "positive regulation of trichome initiation (sensu Magnoliophyta)" EXACT []
is_obsolete: true
consider: GO:0048629

[Term]
id: GO:0048518
name: positive regulation of biological process
namespace: biological_process
alt_id: GO:0043119
def: "Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid]
subset: gosubset_prok
synonym: "activation of biological process" NARROW []
synonym: "positive regulation of physiological process" EXACT []
synonym: "stimulation of biological process" NARROW []
synonym: "up regulation of biological process" EXACT []
synonym: "up-regulation of biological process" EXACT []
synonym: "upregulation of biological process" EXACT []
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008150 ! biological_process
relationship: positively_regulates GO:0008150 ! biological_process

[Term]
id: GO:0048519
name: negative regulation of biological process
namespace: biological_process
alt_id: GO:0043118
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid]
subset: gosubset_prok
synonym: "down regulation of biological process" EXACT []
synonym: "down-regulation of biological process" EXACT []
synonym: "downregulation of biological process" EXACT []
synonym: "inhibition of biological process" NARROW []
synonym: "negative regulation of physiological process" EXACT []
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008150 ! biological_process
relationship: negatively_regulates GO:0008150 ! biological_process

[Term]
id: GO:0048520
name: positive regulation of behavior
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." [GOC:jid, GOC:pr]
synonym: "activation of behavior" NARROW []
synonym: "stimulation of behavior" NARROW []
synonym: "up regulation of behavior" EXACT []
synonym: "up-regulation of behavior" EXACT []
synonym: "upregulation of behavior" EXACT []
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:0050795 ! regulation of behavior
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007610 ! behavior
relationship: positively_regulates GO:0007610 ! behavior

[Term]
id: GO:0048521
name: negative regulation of behavior
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." [GOC:jid, GOC:pr]
synonym: "down regulation of behavior" EXACT []
synonym: "down-regulation of behavior" EXACT []
synonym: "downregulation of behavior" EXACT []
synonym: "inhibition of behavior" NARROW []
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:0050795 ! regulation of behavior
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007610 ! behavior
relationship: negatively_regulates GO:0007610 ! behavior

[Term]
id: GO:0048522
name: positive regulation of cellular process
namespace: biological_process
alt_id: GO:0051242
def: "Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]
subset: gosubset_prok
synonym: "activation of cellular process" NARROW []
synonym: "positive regulation of cellular physiological process" EXACT []
synonym: "stimulation of cellular process" NARROW []
synonym: "up regulation of cellular process" EXACT []
synonym: "up-regulation of cellular process" EXACT []
synonym: "upregulation of cellular process" EXACT []
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009987 ! cellular process
relationship: positively_regulates GO:0009987 ! cellular process

[Term]
id: GO:0048523
name: negative regulation of cellular process
namespace: biological_process
alt_id: GO:0051243
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]
subset: gosubset_prok
synonym: "down regulation of cellular process" EXACT []
synonym: "down-regulation of cellular process" EXACT []
synonym: "downregulation of cellular process" EXACT []
synonym: "inhibition of cellular process" NARROW []
synonym: "negative regulation of cellular physiological process" EXACT []
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009987 ! cellular process
relationship: negatively_regulates GO:0009987 ! cellular process

[Term]
id: GO:0048524
name: positive regulation of viral process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a multi-organism process in which a virus is a participant." [GOC:bf, GOC:jl]
synonym: "activation of viral life cycle" NARROW []
synonym: "positive regulation of viral life cycle" NARROW [GOC:tb]
synonym: "positive regulation of viral reproduction" NARROW [GOC:bf, GOC:jl]
synonym: "stimulation of viral life cycle" NARROW []
synonym: "up regulation of viral life cycle" NARROW []
synonym: "up-regulation of viral life cycle" NARROW []
synonym: "upregulation of viral life cycle" NARROW []
is_a: GO:0043902 ! positive regulation of multi-organism process
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0050792 ! regulation of viral process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016032 ! viral process
relationship: positively_regulates GO:0016032 ! viral process

[Term]
id: GO:0048525
name: negative regulation of viral process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a multi-organism process in which a virus is a participant." [GOC:bf, GOC:jl]
synonym: "down regulation of viral life cycle" NARROW []
synonym: "down-regulation of viral life cycle" NARROW []
synonym: "downregulation of viral life cycle" NARROW []
synonym: "inhibition of viral life cycle" NARROW []
synonym: "negative regulation of viral life cycle" NARROW [GOC:tb]
synonym: "negative regulation of viral reproduction" NARROW [GOC:bf, GOC:jl]
is_a: GO:0043901 ! negative regulation of multi-organism process
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0050792 ! regulation of viral process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016032 ! viral process
relationship: negatively_regulates GO:0016032 ! viral process

[Term]
id: GO:0048526
name: imaginal disc-derived wing expansion
namespace: biological_process
def: "The process of expanding or inflating the folded imaginal disc-derived pupal wing, and the adhering of the dorsal and ventral surfaces, to form the mature adult wing." [GOC:mtg_sensu, GOC:rc]
synonym: "wing expansion" EXACT []
synonym: "wing inflation" EXACT []
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis

[Term]
id: GO:0048527
name: lateral root development
namespace: biological_process
def: "The process whose specific outcome is the progression of the lateral root over time, from its formation to the mature structure. A lateral root is one formed from pericycle cells located on the xylem radius of the root, as opposed to the initiation of the main root from the embryo proper." [GOC:tb]
is_a: GO:0048528 ! post-embryonic root development

[Term]
id: GO:0048528
name: post-embryonic root development
namespace: biological_process
def: "The process whose specific outcome is the progression of the post-embryonic root over time, from its formation to the mature structure." [GOC:tb]
is_a: GO:0009791 ! post-embryonic development
is_a: GO:0048364 ! root development
is_a: GO:0048569 ! post-embryonic organ development

[Term]
id: GO:0048529
name: magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase activity
namespace: molecular_function
def: "Catalysis of the reaction: magnesium protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 H+ + 3 O2 = divinylprotochlorophyllide + 3 NADP+ + 5 H2O." [EC:1.14.13.81]
synonym: "magnesium-protoporphyrin-IX 13-monomethyl ester,NADPH:oxygen oxidoreductase (hydroxylating)" EXACT [EC:1.14.13.81]
synonym: "Mg-protoporphyrin IX monomethyl ester (oxidative) cyclase activity" EXACT [EC:1.14.13.81]
synonym: "Mg-protoporphyrin IX monomethyl ester oxidative cyclase activity" EXACT [EC:1.14.13.81]
xref: EC:1.14.13.81
xref: RHEA:25089
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0048530
name: fruit morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a fruit are generated and organized. A fruit is a reproductive body of a seed plant." [GOC:sm]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0009886 ! post-embryonic morphogenesis
relationship: part_of GO:0010154 ! fruit development

[Term]
id: GO:0048531
name: beta-1,3-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a galactose residue from a donor molecule to an oligosaccharide, forming a beta-1,3-linkage." [PMID:11551958]
is_a: GO:0008378 ! galactosyltransferase activity

[Term]
id: GO:0048532
name: anatomical structure arrangement
namespace: biological_process
def: "The process that gives rise to the configuration of the constituent parts of an anatomical structure. This process pertains to the physical shaping of a rudimentary structure. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:go_curators]
synonym: "anatomical structure organization" BROAD []
synonym: "anatomical structure structural organization" EXACT []
synonym: "organization of an anatomical structure" EXACT []
synonym: "structural organization" EXACT []
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0009653 ! anatomical structure morphogenesis

[Term]
id: GO:0048533
name: sporocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized floral cell acquires the specialized features of a sporocyte. Sporocytes are the haploid spores of angiosperms. Once formed, they undergo meiotic divisions to form microspores and megaspores." [GOC:tair_curators]
synonym: "sporocyte development" NARROW []
synonym: "sporocyte morphogenesis" RELATED []
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0048534
name: hematopoietic or lymphoid organ development
namespace: biological_process
def: "The process whose specific outcome is the progression of any organ involved in hematopoiesis (also known as hemopoiesis) or lymphoid cell activation over time, from its formation to the mature structure. Such development includes differentiation of resident cell types (stromal cells) and of migratory cell types dependent on the unique microenvironment afforded by the organ for their proper differentiation." [GOC:add, GOC:rl, ISBN:0781735149]
synonym: "haematopoietic or lymphoid organ development" EXACT []
synonym: "haemopoietic or lymphoid organ development" EXACT []
synonym: "hemopoietic or lymphoid organ development" EXACT []
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048513 ! animal organ development
relationship: part_of GO:0002520 ! immune system development

[Term]
id: GO:0048535
name: lymph node development
namespace: biological_process
def: "The process whose specific outcome is the progression of lymph nodes over time, from their formation to the mature structure. A lymph node is a round, oval, or bean shaped structure localized in clusters along the lymphatic vessels, with a distinct internal structure including specialized vasculature and B- and T-zones for the activation of lymphocytes." [GOC:add, ISBN:068340007X, ISBN:0781735149]
synonym: "lymph gland development" BROAD []
is_a: GO:0048534 ! hematopoietic or lymphoid organ development

[Term]
id: GO:0048536
name: spleen development
namespace: biological_process
def: "The process whose specific outcome is the progression of the spleen over time, from its formation to the mature structure. The spleen is a large vascular lymphatic organ composed of white and red pulp, involved both in hemopoietic and immune system functions." [GOC:add, ISBN:0781735149]
is_a: GO:0048534 ! hematopoietic or lymphoid organ development

[Term]
id: GO:0048537
name: mucosal-associated lymphoid tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of mucosal-associated lymphoid tissue over time, from its formation to the mature structure. Mucosal-associated lymphoid tissue is typically found as nodules associated with mucosal epithelia with distinct internal structures including B- and T-zones for the activation of lymphocytes." [GOC:add, ISBN:0781735149]
synonym: "BALT development" NARROW []
synonym: "bronchial-associated lymphoid tissue development" NARROW []
synonym: "GALT development" NARROW []
synonym: "gut-associated lymphoid tissue development" NARROW []
synonym: "NALT development" NARROW []
synonym: "nasopharyngeal-associated lymphoid tissue development" NARROW []
is_a: GO:0009888 ! tissue development
is_a: GO:0048534 ! hematopoietic or lymphoid organ development

[Term]
id: GO:0048538
name: thymus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the thymus over time, from its formation to the mature structure. The thymus is a symmetric bi-lobed organ involved primarily in the differentiation of immature to mature T cells, with unique vascular, nervous, epithelial, and lymphoid cell components." [GOC:add, ISBN:0781735149]
comment: Note that this term is reserved for annotation of gene products involved in the formation of the thymus itself, not for gene products involved in T cell differentiation in the thymus or elsewhere.
is_a: GO:0048534 ! hematopoietic or lymphoid organ development
is_a: GO:0048732 ! gland development

[Term]
id: GO:0048539
name: bone marrow development
namespace: biological_process
def: "The process whose specific outcome is the progression of the bone marrow over time, from its formation to the mature structure." [GOC:add, ISBN:0781735149]
is_a: GO:0009888 ! tissue development
is_a: GO:0048534 ! hematopoietic or lymphoid organ development
relationship: part_of GO:0060348 ! bone development

[Term]
id: GO:0048540
name: bursa of Fabricius development
namespace: biological_process
def: "The process whose specific outcome is the progression of the bursa of Fabricius over time, from its formation to the mature structure. The bursa of Fabricius is an organ found in birds involved in B cell differentiation." [GOC:add, ISBN:0781735149]
is_a: GO:0048534 ! hematopoietic or lymphoid organ development

[Term]
id: GO:0048541
name: Peyer's patch development
namespace: biological_process
def: "The process whose specific outcome is the progression of Peyer's patches over time, from their formation to the mature structure. Peyer's patches are typically found as nodules associated with gut epithelium with distinct internal structures including B- and T-zones for the activation of lymphocytes." [GOC:add, ISBN:0781735149]
synonym: "GALT development" RELATED []
synonym: "gut-associated lymphoid tissue development" RELATED []
is_a: GO:0048537 ! mucosal-associated lymphoid tissue development

[Term]
id: GO:0048542
name: lymph gland development
namespace: biological_process
def: "The process whose specific outcome is the progression of the lymph gland over time, from its formation to the mature structure. The lymph gland is one of the sites of hemocyte differentiation. It consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages." [GOC:mtg_sensu, GOC:rc]
synonym: "haematopoietic organ development" BROAD []
synonym: "haemopoietic organ development" BROAD []
synonym: "hematopoietic organ development" BROAD []
synonym: "hemopoietic organ development" BROAD []
is_a: GO:0048534 ! hematopoietic or lymphoid organ development
is_a: GO:0048732 ! gland development

[Term]
id: GO:0048543
name: phytochrome chromophore biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the phytochrome chromophore. The phytochrome chromophore is a linear tetrapyrrolic prosthetic group covalently attached to the large soluble protein phytochrome. Light absorption by the phytochrome chromophore triggers photoconversion between two spectrally distinct forms of the photoreceptor: Pr, the red light absorbing form, and Pfr, the far red light absorbing form." [GOC:pj, PMID:2909515]
synonym: "phytochrome chromophore anabolism" EXACT []
synonym: "phytochrome chromophore biosynthesis" EXACT []
synonym: "phytochrome chromophore formation" EXACT []
synonym: "phytochrome chromophore synthesis" EXACT []
is_a: GO:0046148 ! pigment biosynthetic process

[Term]
id: GO:0048544
name: recognition of pollen
namespace: biological_process
alt_id: GO:0009857
def: "The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species." [GOC:dph, GOC:pj, GOC:tb]
synonym: "pollen recognition" EXACT []
synonym: "recognition or rejection of self pollen" RELATED [GOC:dph, GOC:tb]
synonym: "self incompatibility" RELATED []
is_a: GO:0008037 ! cell recognition
is_a: GO:0044702 ! single organism reproductive process
relationship: part_of GO:0009875 ! pollen-pistil interaction

[Term]
id: GO:0048545
name: response to steroid hormone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus." [GOC:go_curators]
synonym: "response to steroid hormone stimulus" EXACT [GOC:dos]
is_a: GO:0009725 ! response to hormone
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033993 ! response to lipid

[Term]
id: GO:0048546
name: digestive tract morphogenesis
namespace: biological_process
alt_id: GO:0048547
def: "The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:dph, GOC:go_curators, PMID:12618131]
synonym: "alimentary canal morphogenesis" EXACT []
synonym: "digestive tube morphogenesis" EXACT []
synonym: "gastrointestinal tract morphogenesis" EXACT []
synonym: "gut morphogenesis" BROAD [GOC:dph]
synonym: "intestinal morphogenesis" NARROW []
is_a: GO:0035239 ! tube morphogenesis
relationship: part_of GO:0048565 ! digestive tract development

[Term]
id: GO:0048548
name: regulation of pinocytosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pinocytosis. Pinocytosis is the process in which cells take in liquid material from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes." [GOC:go_curators]
is_a: GO:0030100 ! regulation of endocytosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006907 ! pinocytosis
relationship: regulates GO:0006907 ! pinocytosis

[Term]
id: GO:0048549
name: positive regulation of pinocytosis
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of pinocytosis. Pinocytosis is the process in which cells take in liquid material from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes." [GOC:go_curators]
synonym: "activation of pinocytosis" NARROW []
synonym: "stimulation of pinocytosis" NARROW []
synonym: "up regulation of pinocytosis" EXACT []
synonym: "up-regulation of pinocytosis" EXACT []
synonym: "upregulation of pinocytosis" EXACT []
is_a: GO:0045807 ! positive regulation of endocytosis
is_a: GO:0048548 ! regulation of pinocytosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006907 ! pinocytosis
relationship: positively_regulates GO:0006907 ! pinocytosis

[Term]
id: GO:0048550
name: negative regulation of pinocytosis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pinocytosis. Pinocytosis is the process in which cells take in liquid material from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes." [GOC:go_curators]
synonym: "down regulation of pinocytosis" EXACT []
synonym: "down-regulation of pinocytosis" EXACT []
synonym: "downregulation of pinocytosis" EXACT []
synonym: "inhibition of pinocytosis" NARROW []
is_a: GO:0045806 ! negative regulation of endocytosis
is_a: GO:0048548 ! regulation of pinocytosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006907 ! pinocytosis
relationship: negatively_regulates GO:0006907 ! pinocytosis

[Term]
id: GO:0048555
name: generative cell nucleus
namespace: cellular_component
def: "The nucleus of the generative cell, a cell contained within the pollen grain that will divide to produce two haploid sperm cells." [GOC:tair_curators]
synonym: "male germ cell nucleus" BROAD []
synonym: "sperm cell nucleus" BROAD []
is_a: GO:0005634 ! nucleus

[Term]
id: GO:0048556
name: microsporocyte nucleus
namespace: cellular_component
alt_id: GO:0043074
def: "The nucleus of the microsporocyte. The microsporocyte is a diploid cell in which meiosis will occur, resulting in four microspores. A microspore is a spore that, in vascular plants, gives rise to a male gametophyte." [GOC:tair_curators, ISBN:047186840X]
synonym: "microspore mother cell nucleus" EXACT []
synonym: "pollen mother cell nucleus" EXACT []
is_a: GO:0005634 ! nucleus

[Term]
id: GO:0048557
name: embryonic digestive tract morphogenesis
namespace: biological_process
alt_id: GO:0048558
def: "The process in which the anatomical structures of the digestive tract are generated and organized during embryonic development. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:go_curators]
synonym: "embryonic gut morphogenesis" BROAD [GOC:dph]
is_a: GO:0048562 ! embryonic organ morphogenesis
relationship: part_of GO:0048546 ! digestive tract morphogenesis
relationship: part_of GO:0048566 ! embryonic digestive tract development

[Term]
id: GO:0048559
name: establishment of floral organ orientation
namespace: biological_process
def: "The process that determines the orientation of the floral organs with reference to the central axis of the flower." [GOC:jid]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0048561 ! establishment of organ orientation
relationship: part_of GO:0048439 ! flower morphogenesis

[Term]
id: GO:0048560
name: establishment of anatomical structure orientation
namespace: biological_process
def: "The process that determines the orientation of an anatomical structure with reference to an axis." [GOC:jid]
is_a: GO:0009798 ! axis specification
relationship: part_of GO:0009653 ! anatomical structure morphogenesis

[Term]
id: GO:0048561
name: establishment of organ orientation
namespace: biological_process
def: "The process that determines the orientation of an organ or tissue with reference to an axis." [GOC:jid]
is_a: GO:0048560 ! establishment of anatomical structure orientation
relationship: part_of GO:0009887 ! organ morphogenesis

[Term]
id: GO:0048562
name: embryonic organ morphogenesis
namespace: biological_process
def: "Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jid]
is_a: GO:0009887 ! organ morphogenesis
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0048568 ! embryonic organ development

[Term]
id: GO:0048563
name: post-embryonic organ morphogenesis
namespace: biological_process
def: "Morphogenesis, during the post-embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis pertains to process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jid]
is_a: GO:0009886 ! post-embryonic morphogenesis
is_a: GO:0009887 ! organ morphogenesis
relationship: part_of GO:0048569 ! post-embryonic organ development

[Term]
id: GO:0048564
name: photosystem I assembly
namespace: biological_process
alt_id: GO:0010251
def: "The aggregation, arrangement and bonding together of a set of components to form a photosystem I complex on the thylakoid membrane." [GOC:go_curators]
is_a: GO:0043623 ! cellular protein complex assembly
relationship: part_of GO:0019684 ! photosynthesis, light reaction

[Term]
id: GO:0048565
name: digestive tract development
namespace: biological_process
def: "The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:go_curators]
synonym: "gut development" BROAD [GOC:dph]
synonym: "intestinal development" NARROW []
synonym: "intestine development" NARROW []
is_a: GO:0035295 ! tube development
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0055123 ! digestive system development

[Term]
id: GO:0048566
name: embryonic digestive tract development
namespace: biological_process
def: "The process whose specific outcome is the progression of the gut over time, from its formation to the mature structure during embryonic development. The gut is the region of the digestive tract extending from the beginning of the intestines to the anus." [GOC:go_curators]
synonym: "embryonic digestive tract development" BROAD [GOC:dph]
is_a: GO:0048565 ! digestive tract development
is_a: GO:0048568 ! embryonic organ development

[Term]
id: GO:0048567
name: ectodermal digestive tract morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the ectodermal digestive tract are generated and organized. The ectodermal digestive tract includes those portions of the digestive tract that are derived from ectoderm." [GOC:jid]
synonym: "ectodermal gut morphogenesis" RELATED [GOC:dph]
is_a: GO:0007439 ! ectodermal digestive tract development
relationship: part_of GO:0048546 ! digestive tract morphogenesis

[Term]
id: GO:0048568
name: embryonic organ development
namespace: biological_process
def: "Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jid]
synonym: "embryonic organogenesis" EXACT []
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048513 ! animal organ development
relationship: part_of GO:0009790 ! embryo development

[Term]
id: GO:0048569
name: post-embryonic organ development
namespace: biological_process
def: "Development, taking place during the post-embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jid]
synonym: "post-embryonic organogenesis" EXACT []
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048513 ! animal organ development

[Term]
id: GO:0048570
name: notochord morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the notochord are generated and organized. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column." [GOC:jid]
is_a: GO:0048562 ! embryonic organ morphogenesis
relationship: part_of GO:0030903 ! notochord development

[Term]
id: GO:0048571
name: long-day photoperiodism
namespace: biological_process
def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a day length that exceeds a particular duration known as the 'critical day length'. The critical day length varies between species. Although the term long-day is used, most species actually respond to the duration of the night, so that the response will occur when a period of darkness falls short of the number of hours defined by 24 hours minus the critical day length." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862]
synonym: "response to long-day" EXACT []
synonym: "response to long-day photoperiod" RELATED []
synonym: "response to short-night" EXACT []
synonym: "short-night photoperiodism" EXACT []
is_a: GO:0009648 ! photoperiodism

[Term]
id: GO:0048572
name: short-day photoperiodism
namespace: biological_process
def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a day length that falls short of a particular duration known as the 'critical day length'. The critical day length varies between species. Although the term short-day is used, most species actually respond to the duration of the night, so that the response will occur when a period of darkness exceeds the number of hours defined by 24 hours minus the critical day length." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862]
synonym: "long-night photoperiodism" EXACT []
synonym: "response to long-night" EXACT []
synonym: "response to short-day" EXACT []
synonym: "response to short-day photoperiod" RELATED []
is_a: GO:0009648 ! photoperiodism

[Term]
id: GO:0048573
name: photoperiodism, flowering
namespace: biological_process
def: "A change from the vegetative to the reproductive phase as a result of detection of, or exposure to, a period of light or dark of a given length. The length of the period of light or dark required to initiate the change is set relative to a particular duration known as the 'critical day length'. The critical day length varies between species." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862]
synonym: "photoperiodic control of flowering time" EXACT []
synonym: "photoperiodic control of inflorescence development" EXACT []
synonym: "response to day length, flowering" EXACT []
synonym: "response to night length, flowering" EXACT []
synonym: "response to photoperiod, flowering" EXACT []
is_a: GO:0009648 ! photoperiodism
is_a: GO:0022414 ! reproductive process
relationship: part_of GO:0010228 ! vegetative to reproductive phase transition of meristem

[Term]
id: GO:0048574
name: long-day photoperiodism, flowering
namespace: biological_process
def: "A change from the vegetative to the reproductive phase as a result of detection of, or exposure to, a period of light that exceeds the critical day length. The critical day length varies between species. Although the term is long-day is used, most species actually respond to the duration of the night, so that the response will occur when a period of darkness falls short of the number of hours defined by 24 minus the critical day length." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862]
synonym: "long-day photoperiodic control of flowering" EXACT []
synonym: "long-day photoperiodic control of flowering time" EXACT []
synonym: "long-day photoperiodic control of inflorescence development" EXACT []
synonym: "response to long-day, flowering" EXACT []
synonym: "response to short-night, flowering" EXACT []
synonym: "short-night photoperiodism, flowering" EXACT []
is_a: GO:0048571 ! long-day photoperiodism
is_a: GO:0048573 ! photoperiodism, flowering

[Term]
id: GO:0048575
name: short-day photoperiodism, flowering
namespace: biological_process
def: "A change from vegetative to reproductive phase as a result of detection of, or exposure to, a period of light that falls short of the critical day length. The critical day length varies between species. Although the term is short-day is used, most species actually respond to the duration of the night, so that the response will occur when a period of darkness exceeds the number of hours defined by 24 minus the critical day length." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862]
synonym: "long-night photoperiodism, flowering" EXACT []
synonym: "response to long-night, flowering" EXACT []
synonym: "response to short-day, flowering" EXACT []
synonym: "short-day photoperiodic control of flowering" EXACT []
synonym: "short-day photoperiodic control of flowering time" EXACT []
synonym: "short-day photoperiodic control of inflorescence development" EXACT []
is_a: GO:0048572 ! short-day photoperiodism
is_a: GO:0048573 ! photoperiodism, flowering

[Term]
id: GO:0048576
name: positive regulation of short-day photoperiodism, flowering
namespace: biological_process
def: "Any process that activates, maintains or increases short-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862]
synonym: "activation of short-day photoperiodism, flowering" NARROW []
synonym: "stimulation of short-day photoperiodism, flowering" NARROW []
synonym: "up regulation of short-day photoperiodism, flowering" EXACT []
synonym: "up-regulation of short-day photoperiodism, flowering" EXACT []
synonym: "upregulation of short-day photoperiodism, flowering" EXACT []
is_a: GO:0048582 ! positive regulation of post-embryonic development
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:0048587 ! regulation of short-day photoperiodism, flowering
is_a: GO:2000243 ! positive regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048575 ! short-day photoperiodism, flowering
relationship: positively_regulates GO:0048575 ! short-day photoperiodism, flowering

[Term]
id: GO:0048577
name: negative regulation of short-day photoperiodism, flowering
namespace: biological_process
def: "Any process that stops, prevents or reduces short-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862]
synonym: "down regulation of short-day photoperiodism, flowering" EXACT []
synonym: "down-regulation of short-day photoperiodism, flowering" EXACT []
synonym: "downregulation of short-day photoperiodism, flowering" EXACT []
synonym: "inhibition of short-day photoperiodism, flowering" NARROW []
is_a: GO:0048581 ! negative regulation of post-embryonic development
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:0048587 ! regulation of short-day photoperiodism, flowering
is_a: GO:2000242 ! negative regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048575 ! short-day photoperiodism, flowering
relationship: negatively_regulates GO:0048575 ! short-day photoperiodism, flowering

[Term]
id: GO:0048578
name: positive regulation of long-day photoperiodism, flowering
namespace: biological_process
def: "Any process that activates, maintains or increases long-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862]
synonym: "activation of long-day photoperiodism, flowering" NARROW []
synonym: "stimulation of long-day photoperiodism, flowering" NARROW []
synonym: "up regulation of long-day photoperiodism, flowering" EXACT []
synonym: "up-regulation of long-day photoperiodism, flowering" EXACT []
synonym: "upregulation of long-day photoperiodism, flowering" EXACT []
is_a: GO:0048582 ! positive regulation of post-embryonic development
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:0048586 ! regulation of long-day photoperiodism, flowering
is_a: GO:2000243 ! positive regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048574 ! long-day photoperiodism, flowering
relationship: positively_regulates GO:0048574 ! long-day photoperiodism, flowering

[Term]
id: GO:0048579
name: negative regulation of long-day photoperiodism, flowering
namespace: biological_process
def: "Any process that stops, prevents or reduces long-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862]
synonym: "down regulation of long-day photoperiodism, flowering" EXACT []
synonym: "down-regulation of long-day photoperiodism, flowering" EXACT []
synonym: "downregulation of long-day photoperiodism, flowering" EXACT []
synonym: "inhibition of long-day photoperiodism, flowering" NARROW []
is_a: GO:0048581 ! negative regulation of post-embryonic development
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:0048586 ! regulation of long-day photoperiodism, flowering
is_a: GO:2000242 ! negative regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048574 ! long-day photoperiodism, flowering
relationship: negatively_regulates GO:0048574 ! long-day photoperiodism, flowering

[Term]
id: GO:0048580
name: regulation of post-embryonic development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure." [GOC:jid]
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009791 ! post-embryonic development
relationship: regulates GO:0009791 ! post-embryonic development

[Term]
id: GO:0048581
name: negative regulation of post-embryonic development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure." [GOC:jid]
synonym: "down regulation of post-embryonic development" EXACT []
synonym: "down-regulation of post-embryonic development" EXACT []
synonym: "downregulation of post-embryonic development" EXACT []
synonym: "inhibition of post-embryonic development" NARROW []
is_a: GO:0048580 ! regulation of post-embryonic development
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009791 ! post-embryonic development
relationship: negatively_regulates GO:0009791 ! post-embryonic development

[Term]
id: GO:0048582
name: positive regulation of post-embryonic development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure." [GOC:jid]
synonym: "activation of post-embryonic development" NARROW []
synonym: "stimulation of post-embryonic development" NARROW []
synonym: "up regulation of post-embryonic development" EXACT []
synonym: "up-regulation of post-embryonic development" EXACT []
synonym: "upregulation of post-embryonic development" EXACT []
is_a: GO:0048580 ! regulation of post-embryonic development
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009791 ! post-embryonic development
relationship: positively_regulates GO:0009791 ! post-embryonic development

[Term]
id: GO:0048583
name: regulation of response to stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
subset: gosubset_prok
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050896 ! response to stimulus
relationship: regulates GO:0050896 ! response to stimulus

[Term]
id: GO:0048584
name: positive regulation of response to stimulus
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
synonym: "activation of response to stimulus" NARROW []
synonym: "stimulation of response to stimulus" NARROW []
synonym: "up regulation of response to stimulus" EXACT []
synonym: "up-regulation of response to stimulus" EXACT []
synonym: "upregulation of response to stimulus" EXACT []
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:0048583 ! regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0050896 ! response to stimulus
relationship: positively_regulates GO:0050896 ! response to stimulus

[Term]
id: GO:0048585
name: negative regulation of response to stimulus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
synonym: "down regulation of response to stimulus" EXACT []
synonym: "down-regulation of response to stimulus" EXACT []
synonym: "downregulation of response to stimulus" EXACT []
synonym: "inhibition of response to stimulus" NARROW []
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0048583 ! regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0050896 ! response to stimulus
relationship: negatively_regulates GO:0050896 ! response to stimulus

[Term]
id: GO:0048586
name: regulation of long-day photoperiodism, flowering
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of long-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862]
is_a: GO:2000028 ! regulation of photoperiodism, flowering
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048574 ! long-day photoperiodism, flowering
relationship: regulates GO:0048574 ! long-day photoperiodism, flowering

[Term]
id: GO:0048587
name: regulation of short-day photoperiodism, flowering
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of short-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862]
is_a: GO:2000028 ! regulation of photoperiodism, flowering
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048575 ! short-day photoperiodism, flowering
relationship: regulates GO:0048575 ! short-day photoperiodism, flowering

[Term]
id: GO:0048588
name: developmental cell growth
namespace: biological_process
def: "The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another." [GOC:go_curators, GOC:isa_complete]
synonym: "developmental growth of a unicellular organism" EXACT []
is_a: GO:0016049 ! cell growth
is_a: GO:0048589 ! developmental growth
relationship: part_of GO:0048468 ! cell development

[Term]
id: GO:0048589
name: developmental growth
namespace: biological_process
def: "The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another." [GOC:go_curators]
is_a: GO:0040007 ! growth
is_a: GO:0044767 ! single-organism developmental process

[Term]
id: GO:0048592
name: eye morphogenesis
namespace: biological_process
alt_id: GO:0048748
def: "The process in which the anatomical structures of the eye are generated and organized." [GOC:jid, GOC:mtg_sensu]
is_a: GO:0090596 ! sensory organ morphogenesis
relationship: part_of GO:0001654 ! eye development

[Term]
id: GO:0048593
name: camera-type eye morphogenesis
namespace: biological_process
alt_id: GO:0048594
alt_id: GO:0048595
def: "The process in which the anatomical structures of the eye are generated and organized. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field." [GOC:jid, GOC:mtg_sensu]
synonym: "camera-style eye morphogenesis" EXACT [GOC:dph]
is_a: GO:0048592 ! eye morphogenesis
relationship: part_of GO:0043010 ! camera-type eye development

[Term]
id: GO:0048596
name: embryonic camera-type eye morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the eye are generated and organized during embryonic development." [GOC:jid, GOC:mtg_sensu]
synonym: "embryonic eye morphogenesis" BROAD []
is_a: GO:0048048 ! embryonic eye morphogenesis
relationship: part_of GO:0031076 ! embryonic camera-type eye development
relationship: part_of GO:0048593 ! camera-type eye morphogenesis

[Term]
id: GO:0048597
name: post-embryonic camera-type eye morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the eye are generated and organized during post-embryonic development." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]
synonym: "post-embryonic camera-style eye morphogenesis" EXACT []
synonym: "post-embryonic eye morphogenesis" BROAD []
is_a: GO:0048050 ! post-embryonic eye morphogenesis
relationship: part_of GO:0031077 ! post-embryonic camera-type eye development
relationship: part_of GO:0048593 ! camera-type eye morphogenesis

[Term]
id: GO:0048598
name: embryonic morphogenesis
namespace: biological_process
alt_id: GO:0048828
def: "The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants." [GOC:jid, GOC:mtg_sensu]
synonym: "embryonic anatomical structure morphogenesis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0009790 ! embryo development

[Term]
id: GO:0048599
name: oocyte development
namespace: biological_process
def: "The process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:go_curators]
is_a: GO:0007281 ! germ cell development
relationship: part_of GO:0009994 ! oocyte differentiation

[Term]
id: GO:0048600
name: oocyte fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into an oocyte." [GOC:go_curators]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0009994 ! oocyte differentiation

[Term]
id: GO:0048601
name: oocyte morphogenesis
namespace: biological_process
def: "The process in which the structures of an oocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of an oocyte." [GOC:go_curators]
synonym: "oocyte morphogenesis during differentiation" EXACT []
is_a: GO:0000904 ! cell morphogenesis involved in differentiation
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
relationship: part_of GO:0048599 ! oocyte development

[Term]
id: GO:0048608
name: reproductive structure development
namespace: biological_process
def: "The reproductive developmental process whose specific outcome is the progression of structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures." [GOC:dph, GOC:isa_complete, GOC:jid]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0061458 ! reproductive system development

[Term]
id: GO:0048609
name: multicellular organismal reproductive process
namespace: biological_process
def: "The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs." [GOC:dph, GOC:jid, GOC:tb]
synonym: "organismal reproductive process" BROAD [GOC:curators]
synonym: "reproductive process in a multicellular organism" EXACT [GOC:curators]
is_a: GO:0022414 ! reproductive process
relationship: part_of GO:0032504 ! multicellular organism reproduction

[Term]
id: GO:0048610
name: obsolete cellular process involved in reproduction
namespace: biological_process
def: "OBSOLETE. A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular or single-celled organism." [GOC:dph, GOC:jid]
comment: This process was made obsolete because we felt it not provide a particularly useful classification, and its very broad logical definition caused regular problems in our inference pipelines.
subset: gosubset_prok
synonym: "cellular process involved in reproduction" EXACT []
synonym: "reproductive cellular process" RELATED [GOC:dph, GOC:tb]
is_obsolete: true

[Term]
id: GO:0048611
name: embryonic ectodermal digestive tract development
namespace: biological_process
def: "The process, occurring during the embryonic phase, whose specific outcome is the progression of the ectodermal gut over time, from its formation to the mature structure." [GOC:jid, GOC:rc]
synonym: "embryonic ectodermal gut development" RELATED [GOC:dph]
is_a: GO:0048566 ! embryonic digestive tract development
relationship: part_of GO:0007439 ! ectodermal digestive tract development

[Term]
id: GO:0048612
name: post-embryonic ectodermal digestive tract development
namespace: biological_process
def: "The process, occurring during the post-embryonic phase, whose specific outcome is the progression of the ectodermal gut over time, from its formation to the mature structure." [GOC:jid, GOC:rc]
synonym: "post-embryonic ectodermal gut development" RELATED [GOC:dph]
is_a: GO:0048569 ! post-embryonic organ development
relationship: part_of GO:0007439 ! ectodermal digestive tract development

[Term]
id: GO:0048613
name: embryonic ectodermal digestive tract morphogenesis
namespace: biological_process
def: "The process, occurring during the embryonic phase, by which the anatomical structures of the ectodermal digestive tract are generated and organized." [GOC:jid, GOC:rc]
synonym: "embryonic ectodermal gut morphogenesis" RELATED [GOC:dph]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0048557 ! embryonic digestive tract morphogenesis
relationship: part_of GO:0048567 ! ectodermal digestive tract morphogenesis
relationship: part_of GO:0048611 ! embryonic ectodermal digestive tract development

[Term]
id: GO:0048614
name: post-embryonic ectodermal digestive tract morphogenesis
namespace: biological_process
def: "The process, occurring during the post-embryonic phase, by which the anatomical structures of the ectodermal gut are generated and organized." [GOC:jid, GOC:rc]
synonym: "post-embryonic ectodermal gut morphogenesis" RELATED [GOC:dph]
is_a: GO:0009886 ! post-embryonic morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0048567 ! ectodermal digestive tract morphogenesis
relationship: part_of GO:0048612 ! post-embryonic ectodermal digestive tract development
relationship: part_of GO:0048621 ! post-embryonic digestive tract morphogenesis

[Term]
id: GO:0048615
name: embryonic anterior midgut (ectodermal) morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the anterior midgut (ectodermal) are generated and organized, during the embryonic phase." [GOC:jid, GOC:rc]
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
relationship: part_of GO:0007441 ! anterior midgut (ectodermal) morphogenesis
relationship: part_of GO:0048613 ! embryonic ectodermal digestive tract morphogenesis

[Term]
id: GO:0048616
name: post-embryonic anterior midgut (ectodermal) morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the anterior midgut (ectodermal) are generated and organized, during the post-embryonic phase." [GOC:jid, GOC:rc]
is_a: GO:0009886 ! post-embryonic morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0007441 ! anterior midgut (ectodermal) morphogenesis
relationship: part_of GO:0048614 ! post-embryonic ectodermal digestive tract morphogenesis

[Term]
id: GO:0048617
name: embryonic foregut morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the foregut are generated and organized, during the embryonic phase." [GOC:jid, GOC:rc]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0007440 ! foregut morphogenesis

[Term]
id: GO:0048618
name: post-embryonic foregut morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the foregut are generated and organized, during the post-embryonic phase." [GOC:jid, GOC:rc]
is_a: GO:0009886 ! post-embryonic morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0007440 ! foregut morphogenesis

[Term]
id: GO:0048619
name: embryonic hindgut morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the hindgut are generated and organized, during the embryonic phase." [GOC:jid, GOC:rc]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0007442 ! hindgut morphogenesis

[Term]
id: GO:0048620
name: post-embryonic hindgut morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the hindgut are generated and organized, during the post-embryonic phase." [GOC:jid, GOC:rc]
is_a: GO:0009886 ! post-embryonic morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0007442 ! hindgut morphogenesis

[Term]
id: GO:0048621
name: post-embryonic digestive tract morphogenesis
namespace: biological_process
def: "The process, occurring during the post-embryonic phase, by which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:jid, GOC:rc]
synonym: "post-embryonic gut morphogenesis" BROAD [GOC:dph]
is_a: GO:0009886 ! post-embryonic morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0048546 ! digestive tract morphogenesis

[Term]
id: GO:0048622
name: obsolete reproductive sporulation
namespace: biological_process
def: "OBSOLETE. The formation of reproductive spores." [GOC:jid]
comment: This term was made obsolete because it was ambiguously defined and incorrectly placed in the ontology.
synonym: "reproductive sporulation" EXACT []
is_obsolete: true

[Term]
id: GO:0048623
name: seed germination on parent plant
namespace: biological_process
def: "The process in which a seed germinates before being shed from the parent plant." [GOC:go_curators]
synonym: "non-vegetative vivipary" BROAD []
synonym: "pre-harvest sprouting" EXACT []
synonym: "vivipary" BROAD []
is_a: GO:0009845 ! seed germination

[Term]
id: GO:0048624
name: plantlet formation on parent plant
namespace: biological_process
def: "The process in which a new plantlet develops from a meristem on the plant body. As part of this process, when the plantlet is large enough to live independently, the physical connection between the new plantlet and the main plant is severed." [GOC:go_curators]
synonym: "vegetative vivipary" BROAD []
synonym: "vivipary" BROAD []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0019954 ! asexual reproduction
is_a: GO:0044703 ! multi-organism reproductive process
is_a: GO:0044706 ! multi-multicellular organism process
is_a: GO:0048507 ! meristem development
is_a: GO:0048609 ! multicellular organismal reproductive process

[Term]
id: GO:0048625
name: myoblast fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:dph, GOC:mtg_muscle]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0045445 ! myoblast differentiation

[Term]
id: GO:0048626
name: myoblast fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a myoblast in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:dph, GOC:mtg_muscle]
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0048625 ! myoblast fate commitment

[Term]
id: GO:0048627
name: myoblast development
namespace: biological_process
def: "The process whose specific outcome is the progression of the myoblast over time, from its formation to the mature structure. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:dph, GOC:mtg_muscle]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0045445 ! myoblast differentiation

[Term]
id: GO:0048628
name: myoblast maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a myoblast to attain its fully functional state. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:dph, GOC:mtg_muscle]
is_a: GO:0048469 ! cell maturation
relationship: part_of GO:0048627 ! myoblast development

[Term]
id: GO:0048629
name: trichome patterning
namespace: biological_process
def: "The regionalization process of establishing the non-random spatial arrangement of trichomes on the surface and margin of a leaf. Process involves signaling between adjacent epidermal cells that results in differentiation of some epidermal cells into trichomes." [GOC:jid, GOC:mtg_sensu, GOC:sm, GOC:tb, ISBN:0865427429, PMID:10368181]
synonym: "trichome distribution" BROAD []
synonym: "trichome pattern biosynthesis" EXACT []
synonym: "trichome pattern formation" EXACT []
synonym: "trichome pattern specification" RELATED []
synonym: "trichome spacing" EXACT []
is_a: GO:0003002 ! regionalization
is_a: GO:0045168 ! cell-cell signaling involved in cell fate commitment
relationship: part_of GO:0010026 ! trichome differentiation

[Term]
id: GO:0048630
name: skeletal muscle tissue growth
namespace: biological_process
def: "The increase in size or mass of a skeletal muscle. This may be due to a change in the fiber number or size." [GOC:lm, PMID:15726494, PMID:15907921]
is_a: GO:0048589 ! developmental growth
relationship: part_of GO:0007519 ! skeletal muscle tissue development

[Term]
id: GO:0048631
name: regulation of skeletal muscle tissue growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle growth." [GOC:lm, PMID:15726494, PMID:15907921]
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:0048641 ! regulation of skeletal muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048630 ! skeletal muscle tissue growth
relationship: regulates GO:0048630 ! skeletal muscle tissue growth

[Term]
id: GO:0048632
name: negative regulation of skeletal muscle tissue growth
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle growth." [GOC:lm, PMID:15726494, PMID:15907921]
synonym: "down regulation of skeletal muscle growth" EXACT []
synonym: "down-regulation of skeletal muscle growth" EXACT []
synonym: "downregulation of skeletal muscle growth" EXACT []
synonym: "inhibition of skeletal muscle growth" NARROW []
is_a: GO:0048631 ! regulation of skeletal muscle tissue growth
is_a: GO:0048640 ! negative regulation of developmental growth
is_a: GO:0048642 ! negative regulation of skeletal muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048630 ! skeletal muscle tissue growth
relationship: negatively_regulates GO:0048630 ! skeletal muscle tissue growth

[Term]
id: GO:0048633
name: positive regulation of skeletal muscle tissue growth
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of skeletal muscle growth." [GOC:lm, PMID:15726494, PMID:15907921]
synonym: "activation of skeletal muscle growth" NARROW []
synonym: "stimulation of skeletal muscle growth" NARROW []
synonym: "up regulation of skeletal muscle growth" EXACT []
synonym: "up-regulation of skeletal muscle growth" EXACT []
synonym: "upregulation of skeletal muscle growth" EXACT []
is_a: GO:0048631 ! regulation of skeletal muscle tissue growth
is_a: GO:0048639 ! positive regulation of developmental growth
is_a: GO:0048643 ! positive regulation of skeletal muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048630 ! skeletal muscle tissue growth
relationship: positively_regulates GO:0048630 ! skeletal muscle tissue growth

[Term]
id: GO:0048634
name: regulation of muscle organ development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of muscle development." [GOC:go_curators]
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007517 ! muscle organ development
relationship: regulates GO:0007517 ! muscle organ development

[Term]
id: GO:0048635
name: negative regulation of muscle organ development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of muscle development." [GOC:go_curators]
synonym: "down regulation of muscle development" EXACT []
synonym: "down-regulation of muscle development" EXACT []
synonym: "downregulation of muscle development" EXACT []
synonym: "inhibition of muscle development" NARROW []
is_a: GO:0048634 ! regulation of muscle organ development
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007517 ! muscle organ development
relationship: negatively_regulates GO:0007517 ! muscle organ development

[Term]
id: GO:0048636
name: positive regulation of muscle organ development
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of muscle development." [GOC:go_curators]
synonym: "activation of muscle development" NARROW []
synonym: "stimulation of muscle development" NARROW []
synonym: "up regulation of muscle development" EXACT []
synonym: "up-regulation of muscle development" EXACT []
synonym: "upregulation of muscle development" EXACT []
is_a: GO:0048634 ! regulation of muscle organ development
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007517 ! muscle organ development
relationship: positively_regulates GO:0007517 ! muscle organ development

[Term]
id: GO:0048638
name: regulation of developmental growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of developmental growth." [GOC:go_curators]
is_a: GO:0040008 ! regulation of growth
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048589 ! developmental growth
relationship: regulates GO:0048589 ! developmental growth

[Term]
id: GO:0048639
name: positive regulation of developmental growth
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of developmental growth." [GOC:go_curators]
synonym: "activation of developmental growth" NARROW []
synonym: "stimulation of developmental growth" NARROW []
synonym: "up regulation of developmental growth" EXACT []
synonym: "up-regulation of developmental growth" EXACT []
synonym: "upregulation of developmental growth" EXACT []
is_a: GO:0045927 ! positive regulation of growth
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:0051094 ! positive regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048589 ! developmental growth
relationship: positively_regulates GO:0048589 ! developmental growth

[Term]
id: GO:0048640
name: negative regulation of developmental growth
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of developmental growth." [GOC:go_curators]
synonym: "down regulation of developmental growth" EXACT []
synonym: "down-regulation of developmental growth" EXACT []
synonym: "downregulation of developmental growth" EXACT []
synonym: "inhibition of developmental growth" NARROW []
is_a: GO:0045926 ! negative regulation of growth
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:0051093 ! negative regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048589 ! developmental growth
relationship: negatively_regulates GO:0048589 ! developmental growth

[Term]
id: GO:0048641
name: regulation of skeletal muscle tissue development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle tissue development." [GOC:go_curators]
is_a: GO:0016202 ! regulation of striated muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007519 ! skeletal muscle tissue development
relationship: regulates GO:0007519 ! skeletal muscle tissue development

[Term]
id: GO:0048642
name: negative regulation of skeletal muscle tissue development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle tissue development." [GOC:go_curators]
synonym: "down regulation of skeletal muscle development" EXACT []
synonym: "down-regulation of skeletal muscle development" EXACT []
synonym: "downregulation of skeletal muscle development" EXACT []
synonym: "inhibition of skeletal muscle development" NARROW []
is_a: GO:0045843 ! negative regulation of striated muscle tissue development
is_a: GO:0048641 ! regulation of skeletal muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007519 ! skeletal muscle tissue development
relationship: negatively_regulates GO:0007519 ! skeletal muscle tissue development

[Term]
id: GO:0048643
name: positive regulation of skeletal muscle tissue development
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of skeletal muscle tissue development." [GOC:go_curators]
synonym: "activation of skeletal muscle development" NARROW []
synonym: "stimulation of skeletal muscle development" NARROW []
synonym: "up regulation of skeletal muscle development" EXACT []
synonym: "up-regulation of skeletal muscle development" EXACT []
synonym: "upregulation of skeletal muscle development" EXACT []
is_a: GO:0045844 ! positive regulation of striated muscle tissue development
is_a: GO:0048641 ! regulation of skeletal muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007519 ! skeletal muscle tissue development
relationship: positively_regulates GO:0007519 ! skeletal muscle tissue development

[Term]
id: GO:0048644
name: muscle organ morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of muscle are generated and organized." [GOC:jid]
is_a: GO:0009887 ! organ morphogenesis
relationship: part_of GO:0007517 ! muscle organ development

[Term]
id: GO:0048645
name: organ formation
namespace: biological_process
def: "The process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. Organs are a natural part or structure in an animal or a plant, capable of performing some special action (termed its function), which is essential to the life or well-being of the whole. The heart and lungs are organs of animals, and the petal and leaf are organs of plants. In animals the organs are generally made up of several tissues, one of which usually predominates, and determines the principal function of the organ." [GOC:dph, GOC:jid]
synonym: "initiation of an organ primordium" NARROW []
synonym: "organ primordium initiation" NARROW []
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0009887 ! organ morphogenesis

[Term]
id: GO:0048646
name: anatomical structure formation involved in morphogenesis
namespace: biological_process
def: "The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:jid, GOC:tb]
comment: Note that, for example, the formation of a pseudopod in an amoeba would not be considered formation involved in morphogenesis because it would not be thought of as the formation of an anatomical structure that was part of the shaping of the amoeba during its development. The formation of an axon from a neuron would be considered the formation of an anatomical structure involved in morphogenesis because it contributes to the creation of the form of the neuron in a developmental sense.
subset: goslim_chembl
subset: goslim_generic
synonym: "formation of an anatomical structure involved in morphogenesis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0032502 ! developmental process
relationship: part_of GO:0009653 ! anatomical structure morphogenesis

[Term]
id: GO:0048647
name: polyphenic determination
namespace: biological_process
def: "The process in which individuals that have the potential to develop any of several possible distinct developmental paths have their individual developmental fates determined in response to environmental and/or genetic cues." [GOC:jid]
is_a: GO:0044707 ! single-multicellular organism process
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0007275 ! multicellular organism development

[Term]
id: GO:0048648
name: caste determination
namespace: biological_process
def: "The process in which individuals, having the potential to develop any of several distinct developmental paths, have their individual developmental fate determined in response to environmental and/or genetic cues. Individuals with distinct developmental fates perform different functions in a colony of social insects." [GOC:jid]
is_a: GO:0048647 ! polyphenic determination

[Term]
id: GO:0048649
name: caste determination, influence by genetic factors
namespace: biological_process
def: "The process in which individuals, having the potential to develop any of several distinct developmental paths, have their individual developmental fate determined in response to genetic cues. Individuals with distinct developmental fates perform different functions in a colony of social insects." [GOC:jid]
is_a: GO:0048648 ! caste determination
is_a: GO:0048652 ! polyphenic determination, influence by genetic factors

[Term]
id: GO:0048650
name: caste determination, influence by environmental factors
namespace: biological_process
def: "The process in which individuals, having the potential to develop any of several distinct developmental paths, have their individual developmental fate determined in response to environmental cues. Individuals with distinct developmental fates perform different functions in a colony of social insects." [GOC:jid]
is_a: GO:0048648 ! caste determination
is_a: GO:0048651 ! polyphenic determination, influence by environmental factors

[Term]
id: GO:0048651
name: polyphenic determination, influence by environmental factors
namespace: biological_process
def: "The process in which individuals that have the potential to develop any of several possible distinct developmental paths have their individual developmental fates determined in response to environmental cues." [GOC:jid]
is_a: GO:0009605 ! response to external stimulus
is_a: GO:0048647 ! polyphenic determination

[Term]
id: GO:0048652
name: polyphenic determination, influence by genetic factors
namespace: biological_process
def: "The process in which individuals that have the potential to develop any of several possible distinct developmental paths have their individual developmental fates determined in response to genetic cues." [GOC:jid]
is_a: GO:0048647 ! polyphenic determination

[Term]
id: GO:0048653
name: anther development
namespace: biological_process
def: "The process whose specific outcome is the progression of the anther over time, from its formation to the mature structure." [GOC:jid, GOC:sm]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048443 ! stamen development

[Term]
id: GO:0048654
name: anther morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the anther are generated and organized." [GOC:jid, GOC:sm]
is_a: GO:0048444 ! floral organ morphogenesis
relationship: part_of GO:0048448 ! stamen morphogenesis
relationship: part_of GO:0048653 ! anther development

[Term]
id: GO:0048655
name: anther wall tapetum morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the anther wall tapetum are generated and organized. The anther wall tapetum is a layer of cells that provides a source of nutrition for the pollen grains as they mature." [GOC:jid, GOC:sm, GOC:tb]
synonym: "differentiation of tapetal layer" NARROW []
synonym: "tapetal layer morphogenesis" BROAD [GOC:tb]
synonym: "tapetum morphogenesis" BROAD [GOC:tb]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0009886 ! post-embryonic morphogenesis
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0048654 ! anther morphogenesis
relationship: part_of GO:0048658 ! anther wall tapetum development

[Term]
id: GO:0048656
name: anther wall tapetum formation
namespace: biological_process
def: "The process that gives rise to the anther wall tapetum. This process pertains to the initial formation of a structure from unspecified parts. The anther wall tapetum is a layer of cells that provides a source of nutrition for the pollen grains as they mature." [GOC:jid, GOC:sm, GOC:tb]
synonym: "tapetal layer formation" BROAD [GOC:tb]
synonym: "tapetum formation" BROAD [GOC:tb]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0048455 ! stamen formation
relationship: part_of GO:0048655 ! anther wall tapetum morphogenesis

[Term]
id: GO:0048657
name: anther wall tapetum cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an anther cell wall tapetum cell. The tapetum is a layer of cells that provides a source of nutrition for the pollen grains as they mature." [GOC:jid, GOC:sm]
synonym: "tapetal cell differentiation" BROAD [GOC:tb]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0030154 ! cell differentiation
is_a: GO:0044702 ! single organism reproductive process
relationship: part_of GO:0048656 ! anther wall tapetum formation

[Term]
id: GO:0048658
name: anther wall tapetum development
namespace: biological_process
def: "The process whose specific outcome is the progression of the anther wall tapetum over time, from its formation to the mature structure." [GOC:jid, GOC:sm, GOC:tb]
synonym: "tapetal layer development" BROAD [GOC:tb]
synonym: "tapetum development" BROAD [GOC:tb]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048653 ! anther development

[Term]
id: GO:0048659
name: smooth muscle cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of smooth muscle cells, resulting in the expansion of a cell population." [CL:0000192, GOC:ebc, PMID:1840698]
synonym: "SMC proliferation" EXACT []
is_a: GO:0033002 ! muscle cell proliferation

[Term]
id: GO:0048660
name: regulation of smooth muscle cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of smooth muscle cell proliferation." [CL:0000192, GOC:ebc]
synonym: "regulation of SMC proliferation" EXACT []
is_a: GO:0042127 ! regulation of cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048659 ! smooth muscle cell proliferation
relationship: regulates GO:0048659 ! smooth muscle cell proliferation

[Term]
id: GO:0048661
name: positive regulation of smooth muscle cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of smooth muscle cell proliferation." [CL:0000192, GOC:ebc]
synonym: "activation of smooth muscle cell proliferation" NARROW []
synonym: "positive regulation of SMC proliferation" EXACT []
synonym: "stimulation of smooth muscle cell proliferation" NARROW []
synonym: "up regulation of smooth muscle cell proliferation" EXACT []
synonym: "up-regulation of smooth muscle cell proliferation" EXACT []
synonym: "upregulation of smooth muscle cell proliferation" EXACT []
is_a: GO:0008284 ! positive regulation of cell proliferation
is_a: GO:0048660 ! regulation of smooth muscle cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048659 ! smooth muscle cell proliferation
relationship: positively_regulates GO:0048659 ! smooth muscle cell proliferation

[Term]
id: GO:0048662
name: negative regulation of smooth muscle cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation." [CL:0000192, GOC:ebc]
synonym: "down regulation of smooth muscle cell proliferation" EXACT []
synonym: "down-regulation of smooth muscle cell proliferation" EXACT []
synonym: "downregulation of smooth muscle cell proliferation" EXACT []
synonym: "inhibition of smooth muscle cell proliferation" NARROW []
synonym: "negative regulation of SMC proliferation" EXACT []
is_a: GO:0008285 ! negative regulation of cell proliferation
is_a: GO:0048660 ! regulation of smooth muscle cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048659 ! smooth muscle cell proliferation
relationship: negatively_regulates GO:0048659 ! smooth muscle cell proliferation

[Term]
id: GO:0048663
name: neuron fate commitment
namespace: biological_process
alt_id: GO:0042055
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron." [GOC:dph]
synonym: "neuron lineage restriction" EXACT []
synonym: "neuronal lineage restriction" EXACT []
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0030182 ! neuron differentiation

[Term]
id: GO:0048664
name: neuron fate determination
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a neuron regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:dph]
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0048663 ! neuron fate commitment

[Term]
id: GO:0048665
name: neuron fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:dph]
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0048663 ! neuron fate commitment

[Term]
id: GO:0048666
name: neuron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0030182 ! neuron differentiation

[Term]
id: GO:0048667
name: cell morphogenesis involved in neuron differentiation
namespace: biological_process
def: "The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron." [GOC:dph, GOC:tb]
synonym: "neuron morphogenesis involved in differentiation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0000904 ! cell morphogenesis involved in differentiation
intersection_of: GO:0000902 ! cell morphogenesis
intersection_of: part_of GO:0030182 ! neuron differentiation
relationship: part_of GO:0030182 ! neuron differentiation
relationship: part_of GO:0048666 ! neuron development

[Term]
id: GO:0048668
name: collateral sprouting
namespace: biological_process
def: "The process in which outgrowths develop from the shafts of existing axons." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
synonym: "axon branching" BROAD [GOC:BHF, PMID:21463686]
is_a: GO:0048588 ! developmental cell growth
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0007409 ! axonogenesis

[Term]
id: GO:0048669
name: collateral sprouting in absence of injury
namespace: biological_process
def: "The process in which outgrowths develop from the axons of intact undamaged neurons." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
is_a: GO:0048668 ! collateral sprouting

[Term]
id: GO:0048670
name: regulation of collateral sprouting
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of collateral sprouting." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:0050770 ! regulation of axonogenesis
is_a: GO:0061387 ! regulation of extent of cell growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048668 ! collateral sprouting
relationship: regulates GO:0048668 ! collateral sprouting

[Term]
id: GO:0048671
name: negative regulation of collateral sprouting
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of collateral sprouting." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
synonym: "down regulation of collateral sprouting" EXACT []
synonym: "down-regulation of collateral sprouting" EXACT []
synonym: "downregulation of collateral sprouting" EXACT []
synonym: "inhibition of collateral sprouting" NARROW []
is_a: GO:0030308 ! negative regulation of cell growth
is_a: GO:0048640 ! negative regulation of developmental growth
is_a: GO:0048670 ! regulation of collateral sprouting
is_a: GO:0050771 ! negative regulation of axonogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048668 ! collateral sprouting
relationship: negatively_regulates GO:0048668 ! collateral sprouting

[Term]
id: GO:0048672
name: positive regulation of collateral sprouting
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of collateral sprouting." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
synonym: "activation of collateral sprouting" NARROW []
synonym: "stimulation of collateral sprouting" NARROW []
synonym: "up regulation of collateral sprouting" EXACT []
synonym: "up-regulation of collateral sprouting" EXACT []
synonym: "upregulation of collateral sprouting" EXACT []
is_a: GO:0030307 ! positive regulation of cell growth
is_a: GO:0048639 ! positive regulation of developmental growth
is_a: GO:0048670 ! regulation of collateral sprouting
is_a: GO:0050772 ! positive regulation of axonogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048668 ! collateral sprouting
relationship: positively_regulates GO:0048668 ! collateral sprouting

[Term]
id: GO:0048673
name: collateral sprouting of intact axon in response to injury
namespace: biological_process
def: "The process in which outgrowths develop from the axons of intact undamaged neurons as a result of injury to an axon. The collateral sprouts typically appear from undamaged axons in a tissue which has had part of its nerve supply removed, and they can often innervate successfully any cells that have lost some or all of their original synaptic input." [GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0031103 ! axon regeneration
is_a: GO:0048668 ! collateral sprouting

[Term]
id: GO:0048674
name: collateral sprouting of injured axon
namespace: biological_process
def: "The process resulting in reformation of a growth cone by the tip of an injured axon, or in collateral sprouting of the axon. Collateral sprouting is the process in which outgrowths develop from the shafts of existing axons." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
is_a: GO:0048668 ! collateral sprouting
is_a: GO:0048682 ! sprouting of injured axon

[Term]
id: GO:0048675
name: axon extension
namespace: biological_process
alt_id: GO:0048676
def: "Long distance growth of a single axon process involved in cellular development." [GOC:BHF, GOC:dgh, GOC:dph, GOC:jid, GOC:lm, GOC:rl]
synonym: "axon extension involved in development" EXACT []
is_a: GO:1990138 ! neuron projection extension
relationship: part_of GO:0007409 ! axonogenesis

[Term]
id: GO:0048677
name: axon extension involved in regeneration
namespace: biological_process
def: "Long distance growth of a single axon process involved in regeneration of the neuron." [GOC:jid]
is_a: GO:0048675 ! axon extension
is_a: GO:0048682 ! sprouting of injured axon
intersection_of: GO:0048675 ! axon extension
intersection_of: part_of GO:0031099 ! regeneration
relationship: part_of GO:0031099 ! regeneration

[Term]
id: GO:0048678
name: response to axon injury
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an axon injury stimulus." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
is_a: GO:0009611 ! response to wounding

[Term]
id: GO:0048679
name: regulation of axon regeneration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of axon regeneration." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
is_a: GO:0032101 ! regulation of response to external stimulus
is_a: GO:0070570 ! regulation of neuron projection regeneration
is_a: GO:1903034 ! regulation of response to wounding
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031103 ! axon regeneration
relationship: regulates GO:0031103 ! axon regeneration

[Term]
id: GO:0048680
name: positive regulation of axon regeneration
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of axon regeneration." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
synonym: "activation of axon regeneration" NARROW []
synonym: "stimulation of axon regeneration" NARROW []
synonym: "up regulation of axon regeneration" EXACT []
synonym: "up-regulation of axon regeneration" EXACT []
synonym: "upregulation of axon regeneration" EXACT []
is_a: GO:0032103 ! positive regulation of response to external stimulus
is_a: GO:0048679 ! regulation of axon regeneration
is_a: GO:0070572 ! positive regulation of neuron projection regeneration
is_a: GO:1903036 ! positive regulation of response to wounding
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0031103 ! axon regeneration
relationship: positively_regulates GO:0031103 ! axon regeneration

[Term]
id: GO:0048681
name: negative regulation of axon regeneration
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of axon regeneration." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
synonym: "down regulation of axon regeneration" EXACT []
synonym: "down-regulation of axon regeneration" EXACT []
synonym: "downregulation of axon regeneration" EXACT []
synonym: "inhibition of axon regeneration" NARROW []
is_a: GO:0032102 ! negative regulation of response to external stimulus
is_a: GO:0048679 ! regulation of axon regeneration
is_a: GO:0070571 ! negative regulation of neuron projection regeneration
is_a: GO:1903035 ! negative regulation of response to wounding
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0031103 ! axon regeneration
relationship: negatively_regulates GO:0031103 ! axon regeneration

[Term]
id: GO:0048682
name: sprouting of injured axon
namespace: biological_process
def: "The process involved in sprouting of an injured axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
is_a: GO:0048588 ! developmental cell growth
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0031103 ! axon regeneration

[Term]
id: GO:0048683
name: regulation of collateral sprouting of intact axon in response to injury
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of collateral sprouting of an intact axon as a result of injury to an axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
is_a: GO:0048670 ! regulation of collateral sprouting
is_a: GO:0048679 ! regulation of axon regeneration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048673 ! collateral sprouting of intact axon in response to injury
relationship: regulates GO:0048673 ! collateral sprouting of intact axon in response to injury

[Term]
id: GO:0048684
name: positive regulation of collateral sprouting of intact axon in response to injury
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of collateral sprouting of an intact axon as a result of injury to an axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
synonym: "activation of collateral sprouting of intact axon in response to injury" NARROW []
synonym: "stimulation of collateral sprouting of intact axon in response to injury" NARROW []
synonym: "up regulation of collateral sprouting of intact axon in response to injury" EXACT []
synonym: "up-regulation of collateral sprouting of intact axon in response to injury" EXACT []
synonym: "upregulation of collateral sprouting of intact axon in response to injury" EXACT []
is_a: GO:0048672 ! positive regulation of collateral sprouting
is_a: GO:0048680 ! positive regulation of axon regeneration
is_a: GO:0048683 ! regulation of collateral sprouting of intact axon in response to injury
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048673 ! collateral sprouting of intact axon in response to injury
relationship: positively_regulates GO:0048673 ! collateral sprouting of intact axon in response to injury

[Term]
id: GO:0048685
name: negative regulation of collateral sprouting of intact axon in response to injury
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of collateral sprouting of an intact axon as a result of injury to an axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
synonym: "down regulation of collateral sprouting of intact axon in response to injury" EXACT []
synonym: "down-regulation of collateral sprouting of intact axon in response to injury" EXACT []
synonym: "downregulation of collateral sprouting of intact axon in response to injury" EXACT []
synonym: "inhibition of collateral sprouting of intact axon in response to injury" NARROW []
is_a: GO:0048671 ! negative regulation of collateral sprouting
is_a: GO:0048681 ! negative regulation of axon regeneration
is_a: GO:0048683 ! regulation of collateral sprouting of intact axon in response to injury
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048673 ! collateral sprouting of intact axon in response to injury
relationship: negatively_regulates GO:0048673 ! collateral sprouting of intact axon in response to injury

[Term]
id: GO:0048686
name: regulation of sprouting of injured axon
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sprouting of an injured axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:0048679 ! regulation of axon regeneration
is_a: GO:0061387 ! regulation of extent of cell growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048682 ! sprouting of injured axon
relationship: regulates GO:0048682 ! sprouting of injured axon

[Term]
id: GO:0048687
name: positive regulation of sprouting of injured axon
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of sprouting of an injured axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
synonym: "activation of sprouting of injured axon" NARROW []
synonym: "stimulation of sprouting of injured axon" NARROW []
synonym: "up regulation of sprouting of injured axon" EXACT []
synonym: "up-regulation of sprouting of injured axon" EXACT []
synonym: "upregulation of sprouting of injured axon" EXACT []
is_a: GO:0030307 ! positive regulation of cell growth
is_a: GO:0048639 ! positive regulation of developmental growth
is_a: GO:0048680 ! positive regulation of axon regeneration
is_a: GO:0048686 ! regulation of sprouting of injured axon
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048682 ! sprouting of injured axon
relationship: positively_regulates GO:0048682 ! sprouting of injured axon

[Term]
id: GO:0048688
name: negative regulation of sprouting of injured axon
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sprouting of an injured axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
synonym: "down regulation of sprouting of injured axon" EXACT []
synonym: "down-regulation of sprouting of injured axon" EXACT []
synonym: "downregulation of sprouting of injured axon" EXACT []
synonym: "inhibition of sprouting of injured axon" NARROW []
is_a: GO:0030308 ! negative regulation of cell growth
is_a: GO:0048640 ! negative regulation of developmental growth
is_a: GO:0048681 ! negative regulation of axon regeneration
is_a: GO:0048686 ! regulation of sprouting of injured axon
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048682 ! sprouting of injured axon
relationship: negatively_regulates GO:0048682 ! sprouting of injured axon

[Term]
id: GO:0048689
name: formation of growth cone in injured axon
namespace: biological_process
def: "The formation of a growth cone in an injured axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
is_a: GO:0048682 ! sprouting of injured axon

[Term]
id: GO:0048690
name: regulation of axon extension involved in regeneration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of axon extension involved in regeneration." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
is_a: GO:0030516 ! regulation of axon extension
is_a: GO:0048686 ! regulation of sprouting of injured axon
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048677 ! axon extension involved in regeneration
relationship: regulates GO:0048677 ! axon extension involved in regeneration

[Term]
id: GO:0048691
name: positive regulation of axon extension involved in regeneration
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of axon extension involved in regeneration." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
synonym: "activation of axon extension involved in regeneration" NARROW []
synonym: "stimulation of axon extension involved in regeneration" NARROW []
synonym: "up regulation of axon extension involved in regeneration" EXACT []
synonym: "up-regulation of axon extension involved in regeneration" EXACT []
synonym: "upregulation of axon extension involved in regeneration" EXACT []
is_a: GO:0045773 ! positive regulation of axon extension
is_a: GO:0048687 ! positive regulation of sprouting of injured axon
is_a: GO:0048690 ! regulation of axon extension involved in regeneration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048677 ! axon extension involved in regeneration
relationship: positively_regulates GO:0048677 ! axon extension involved in regeneration

[Term]
id: GO:0048692
name: negative regulation of axon extension involved in regeneration
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of axon extension involved in regeneration." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
synonym: "down regulation of axon extension involved in regeneration" EXACT []
synonym: "down-regulation of axon extension involved in regeneration" EXACT []
synonym: "downregulation of axon extension involved in regeneration" EXACT []
synonym: "inhibition of axon extension involved in regeneration" NARROW []
is_a: GO:0030517 ! negative regulation of axon extension
is_a: GO:0048688 ! negative regulation of sprouting of injured axon
is_a: GO:0048690 ! regulation of axon extension involved in regeneration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048677 ! axon extension involved in regeneration
relationship: negatively_regulates GO:0048677 ! axon extension involved in regeneration

[Term]
id: GO:0048693
name: regulation of collateral sprouting of injured axon
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of collateral sprouting of an injured axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
is_a: GO:0048670 ! regulation of collateral sprouting
is_a: GO:0048686 ! regulation of sprouting of injured axon
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048674 ! collateral sprouting of injured axon
relationship: regulates GO:0048674 ! collateral sprouting of injured axon

[Term]
id: GO:0048694
name: positive regulation of collateral sprouting of injured axon
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of collateral sprouting of an injured axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
synonym: "activation of collateral sprouting of injured axon" NARROW []
synonym: "stimulation of collateral sprouting of injured axon" NARROW []
synonym: "up regulation of collateral sprouting of injured axon" EXACT []
synonym: "up-regulation of collateral sprouting of injured axon" EXACT []
synonym: "upregulation of collateral sprouting of injured axon" EXACT []
is_a: GO:0048672 ! positive regulation of collateral sprouting
is_a: GO:0048687 ! positive regulation of sprouting of injured axon
is_a: GO:0048693 ! regulation of collateral sprouting of injured axon
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048674 ! collateral sprouting of injured axon
relationship: positively_regulates GO:0048674 ! collateral sprouting of injured axon

[Term]
id: GO:0048695
name: negative regulation of collateral sprouting of injured axon
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of collateral sprouting of an injured axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
synonym: "down regulation of collateral sprouting of injured axon" EXACT []
synonym: "down-regulation of collateral sprouting of injured axon" EXACT []
synonym: "downregulation of collateral sprouting of injured axon" EXACT []
synonym: "inhibition of collateral sprouting of injured axon" NARROW []
is_a: GO:0048671 ! negative regulation of collateral sprouting
is_a: GO:0048688 ! negative regulation of sprouting of injured axon
is_a: GO:0048693 ! regulation of collateral sprouting of injured axon
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048674 ! collateral sprouting of injured axon
relationship: negatively_regulates GO:0048674 ! collateral sprouting of injured axon

[Term]
id: GO:0048696
name: regulation of collateral sprouting in absence of injury
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of collateral sprouting in the absence of injury." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
is_a: GO:0048670 ! regulation of collateral sprouting
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048669 ! collateral sprouting in absence of injury
relationship: regulates GO:0048669 ! collateral sprouting in absence of injury

[Term]
id: GO:0048697
name: positive regulation of collateral sprouting in absence of injury
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of collateral sprouting in the absence of injury." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
synonym: "activation of collateral sprouting in the absence of injury" NARROW []
synonym: "stimulation of collateral sprouting in the absence of injury" NARROW []
synonym: "up regulation of collateral sprouting in the absence of injury" EXACT []
synonym: "up-regulation of collateral sprouting in the absence of injury" EXACT []
synonym: "upregulation of collateral sprouting in the absence of injury" EXACT []
is_a: GO:0048672 ! positive regulation of collateral sprouting
is_a: GO:0048696 ! regulation of collateral sprouting in absence of injury
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048669 ! collateral sprouting in absence of injury
relationship: positively_regulates GO:0048669 ! collateral sprouting in absence of injury

[Term]
id: GO:0048698
name: negative regulation of collateral sprouting in absence of injury
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of collateral sprouting in the absence of injury." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
synonym: "down regulation of collateral sprouting in the absence of injury" EXACT []
synonym: "down-regulation of collateral sprouting in the absence of injury" EXACT []
synonym: "downregulation of collateral sprouting in the absence of injury" EXACT []
synonym: "inhibition of collateral sprouting in the absence of injury" NARROW []
is_a: GO:0048671 ! negative regulation of collateral sprouting
is_a: GO:0048696 ! regulation of collateral sprouting in absence of injury
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048669 ! collateral sprouting in absence of injury
relationship: negatively_regulates GO:0048669 ! collateral sprouting in absence of injury

[Term]
id: GO:0048699
name: generation of neurons
namespace: biological_process
def: "The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons." [GOC:nln]
synonym: "neuron generation" EXACT [GOC:curators]
is_a: GO:0022008 ! neurogenesis

[Term]
id: GO:0048700
name: acquisition of desiccation tolerance in seed
namespace: biological_process
def: "The process in which a seed acquires tolerance to severe drying, before entering into a dry, either dormant or quiescent state." [GOC:jid, GOC:ki, GOC:PO_curators, ISBN:9781405139830]
synonym: "acquisition of desiccation tolerance" BROAD []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0097439 ! acquisition of desiccation tolerance
relationship: part_of GO:0010162 ! seed dormancy process

[Term]
id: GO:0048701
name: embryonic cranial skeleton morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the cranial skeleton are generated and organized during the embryonic phase." [GOC:dsf, GOC:jid, PMID:16049113]
synonym: "embryonic cranium morphogenesis" EXACT []
is_a: GO:0048704 ! embryonic skeletal system morphogenesis
relationship: part_of GO:1904888 ! cranial skeletal system development

[Term]
id: GO:0048702
name: embryonic neurocranium morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the neurocranium are generated and organized during the embryonic phase. The neurocranium is the portion of the vertebrate skull surrounding the brain." [GOC:dsf, GOC:jid, PMID:16049113]
synonym: "embryonic braincase morphogenesis" EXACT []
synonym: "embryonic chondrocranium morphogenesis" EXACT [GOC:dph]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0048701 ! embryonic cranial skeleton morphogenesis

[Term]
id: GO:0048703
name: embryonic viscerocranium morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the viscerocranium are generated and organized during the embryonic phase. The viscerocranium is the part of the skull comprising the facial bones." [GOC:dsf, GOC:jid, PMID:16049113]
synonym: "embryonic pharyngeal skeleton morphogenesis" EXACT []
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0048701 ! embryonic cranial skeleton morphogenesis

[Term]
id: GO:0048704
name: embryonic skeletal system morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the skeleton are generated and organized during the embryonic phase." [GOC:dph, GOC:dsf, GOC:jid, GOC:tb, PMID:16049113]
synonym: "embryonic skeletal morphogenesis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0048562 ! embryonic organ morphogenesis
is_a: GO:0048705 ! skeletal system morphogenesis
relationship: part_of GO:0048706 ! embryonic skeletal system development

[Term]
id: GO:0048705
name: skeletal system morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the skeleton are generated and organized." [GOC:dph, GOC:dsf, GOC:jid, GOC:tb]
synonym: "skeletal morphogenesis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0009887 ! organ morphogenesis
relationship: part_of GO:0001501 ! skeletal system development

[Term]
id: GO:0048706
name: embryonic skeletal system development
namespace: biological_process
def: "The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure." [GOC:dph, GOC:dsf, GOC:jid, GOC:tb, PMID:16049113]
synonym: "embryonic skeletal development" EXACT [GOC:dph, GOC:tb]
is_a: GO:0001501 ! skeletal system development
relationship: part_of GO:0043009 ! chordate embryonic development

[Term]
id: GO:0048707
name: instar larval or pupal morphogenesis
namespace: biological_process
def: "The process, occurring during instar larval or pupal development, by which anatomical structures are generated and organized." [GOC:mtg_sensu, GOC:rc]
is_a: GO:0009886 ! post-embryonic morphogenesis
relationship: part_of GO:0002165 ! instar larval or pupal development

[Term]
id: GO:0048708
name: astrocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function." [GOC:vp, PMID:15139015]
is_a: GO:0010001 ! glial cell differentiation
relationship: part_of GO:0007417 ! central nervous system development

[Term]
id: GO:0048709
name: oligodendrocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system." [GOC:vp, PMID:15139015]
is_a: GO:0010001 ! glial cell differentiation
relationship: part_of GO:0007417 ! central nervous system development

[Term]
id: GO:0048710
name: regulation of astrocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of astrocyte differentiation." [GOC:vp, PMID:15139015]
is_a: GO:0045685 ! regulation of glial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048708 ! astrocyte differentiation
relationship: regulates GO:0048708 ! astrocyte differentiation

[Term]
id: GO:0048711
name: positive regulation of astrocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of astrocyte differentiation." [GOC:vp, PMID:15139015]
synonym: "activation of astrocyte differentiation" NARROW []
synonym: "stimulation of astrocyte differentiation" NARROW []
synonym: "up regulation of astrocyte differentiation" EXACT []
synonym: "up-regulation of astrocyte differentiation" EXACT []
synonym: "upregulation of astrocyte differentiation" EXACT []
is_a: GO:0045687 ! positive regulation of glial cell differentiation
is_a: GO:0048710 ! regulation of astrocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048708 ! astrocyte differentiation
relationship: positively_regulates GO:0048708 ! astrocyte differentiation

[Term]
id: GO:0048712
name: negative regulation of astrocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of astrocyte differentiation." [GOC:vp, PMID:15139015]
synonym: "down regulation of astrocyte differentiation" EXACT []
synonym: "down-regulation of astrocyte differentiation" EXACT []
synonym: "downregulation of astrocyte differentiation" EXACT []
synonym: "inhibition of astrocyte differentiation" NARROW []
is_a: GO:0045686 ! negative regulation of glial cell differentiation
is_a: GO:0048710 ! regulation of astrocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048708 ! astrocyte differentiation
relationship: negatively_regulates GO:0048708 ! astrocyte differentiation

[Term]
id: GO:0048713
name: regulation of oligodendrocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of oligodendrocyte differentiation." [GOC:vp, PMID:15139015]
is_a: GO:0045685 ! regulation of glial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048709 ! oligodendrocyte differentiation
relationship: regulates GO:0048709 ! oligodendrocyte differentiation

[Term]
id: GO:0048714
name: positive regulation of oligodendrocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of oligodendrocyte differentiation." [GOC:vp, PMID:15139015]
synonym: "activation of oligodendrocyte differentiation" NARROW []
synonym: "stimulation of oligodendrocyte differentiation" NARROW []
synonym: "up regulation of oligodendrocyte differentiation" EXACT []
synonym: "up-regulation of oligodendrocyte differentiation" EXACT []
synonym: "upregulation of oligodendrocyte differentiation" EXACT []
is_a: GO:0045687 ! positive regulation of glial cell differentiation
is_a: GO:0048713 ! regulation of oligodendrocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048709 ! oligodendrocyte differentiation
relationship: positively_regulates GO:0048709 ! oligodendrocyte differentiation

[Term]
id: GO:0048715
name: negative regulation of oligodendrocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of oligodendrocyte differentiation." [GOC:vp, PMID:15139015]
synonym: "down regulation of oligodendrocyte differentiation" EXACT []
synonym: "down-regulation of oligodendrocyte differentiation" EXACT []
synonym: "downregulation of oligodendrocyte differentiation" EXACT []
synonym: "inhibition of oligodendrocyte differentiation" NARROW []
is_a: GO:0045686 ! negative regulation of glial cell differentiation
is_a: GO:0048713 ! regulation of oligodendrocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048709 ! oligodendrocyte differentiation
relationship: negatively_regulates GO:0048709 ! oligodendrocyte differentiation

[Term]
id: GO:0048716
name: labrum morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of labrum are generated and organized." [GOC:rc]
is_a: GO:0009886 ! post-embryonic morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0007453 ! clypeo-labral disc morphogenesis
relationship: part_of GO:0048726 ! labrum development

[Term]
id: GO:0048717
name: anterior cibarial plate morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the anterior cibarial plate are generated and organized." [GOC:rc]
is_a: GO:0009886 ! post-embryonic morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0007453 ! clypeo-labral disc morphogenesis
relationship: part_of GO:0048722 ! anterior cibarial plate development

[Term]
id: GO:0048718
name: cibarial fish-trap bristle morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a cibarial fish-trap bristle are generated and organized. A cibarial fish-trap bristle is a sensory bristle on the anterior plate of the cibarium." [FBbt:00004136, GOC:rc]
synonym: "fish trap bristle morphogenesis" RELATED [GOC:rc]
is_a: GO:0008407 ! chaeta morphogenesis
is_a: GO:0048563 ! post-embryonic organ morphogenesis
relationship: part_of GO:0007453 ! clypeo-labral disc morphogenesis
relationship: part_of GO:0048725 ! cibarial fish-trap bristle development

[Term]
id: GO:0048719
name: epistomal sclerite morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the epistomal sclerite are generated and organized." [GOC:rc]
is_a: GO:0009886 ! post-embryonic morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0007453 ! clypeo-labral disc morphogenesis
relationship: part_of GO:0048724 ! epistomal sclerite development

[Term]
id: GO:0048720
name: posterior cibarial plate morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the posterior cibarial plate are generated and organized." [GOC:rc]
is_a: GO:0009886 ! post-embryonic morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0007453 ! clypeo-labral disc morphogenesis
relationship: part_of GO:0048727 ! posterior cibarial plate development

[Term]
id: GO:0048721
name: clypeus morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the clypeus are generated and organized." [GOC:rc]
is_a: GO:0009886 ! post-embryonic morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0007453 ! clypeo-labral disc morphogenesis
relationship: part_of GO:0048723 ! clypeus development

[Term]
id: GO:0048722
name: anterior cibarial plate development
namespace: biological_process
def: "The process whose specific outcome is the progression of the anterior cibarial plate over time, from their formation to the mature structure." [GOC:rc]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0035213 ! clypeo-labral disc development

[Term]
id: GO:0048723
name: clypeus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the clypeus over time, from its formation to the mature structure. The clypeus is the shield-shaped plate on an insect's head." [GOC:rc]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0035213 ! clypeo-labral disc development

[Term]
id: GO:0048724
name: epistomal sclerite development
namespace: biological_process
def: "The process whose specific outcome is the progression of the epistomal sclerite over time, from its formation to the mature structure." [GOC:rc]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0035213 ! clypeo-labral disc development

[Term]
id: GO:0048725
name: cibarial fish-trap bristle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cibarial fish-trap bristle over time, from its formation to the mature structure. A cibarial fish-trap bristle is a sensory bristle on the anterior plate of the cibarium." [FBbt:00004136, GOC:rc]
synonym: "fish-trap bristle development" EXACT [GOC:rc]
is_a: GO:0022416 ! chaeta development
relationship: part_of GO:0035213 ! clypeo-labral disc development

[Term]
id: GO:0048726
name: labrum development
namespace: biological_process
def: "The process whose specific outcome is the progression of the labrum over time, from its formation to the mature structure." [GOC:rc]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0035213 ! clypeo-labral disc development

[Term]
id: GO:0048727
name: posterior cibarial plate development
namespace: biological_process
def: "The process whose specific outcome is the progression of the posterior cibarial plate over time, from its formation to the mature structure." [GOC:rc]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0035213 ! clypeo-labral disc development

[Term]
id: GO:0048728
name: proboscis development
namespace: biological_process
alt_id: GO:0016349
def: "The process whose specific outcome is the progression of the proboscis over time, from its formation to the mature structure." [GOC:rc]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048513 ! animal organ development
relationship: part_of GO:0035213 ! clypeo-labral disc development

[Term]
id: GO:0048729
name: tissue morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a tissue are generated and organized." [GOC:dph, GOC:jid]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0009888 ! tissue development

[Term]
id: GO:0048730
name: epidermis morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the epidermis are generated and organized. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species." [GOC:jid, UBERON:0001003]
synonym: "hypodermis morphogenesis" RELATED [GOC:kmv, GOC:rk]
is_a: GO:0002009 ! morphogenesis of an epithelium
relationship: part_of GO:0008544 ! epidermis development

[Term]
id: GO:0048731
name: system development
namespace: biological_process
def: "The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007275 ! multicellular organism development

[Term]
id: GO:0048732
name: gland development
namespace: biological_process
def: "The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion." [GOC:jid]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048513 ! animal organ development

[Term]
id: GO:0048733
name: sebaceous gland development
namespace: biological_process
def: "The process whose specific outcome is the progression of the sebaceous gland over time, from its formation to the mature structure." [GOC:jid]
is_a: GO:0048732 ! gland development
relationship: part_of GO:0043588 ! skin development

[Term]
id: GO:0048734
name: proboscis morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the proboscis are generated and organized. The proboscis is the trunk-like extension of the mouthparts on the adult head." [GOC:jid, GOC:rc]
is_a: GO:0009887 ! organ morphogenesis
relationship: part_of GO:0048728 ! proboscis development

[Term]
id: GO:0048735
name: haltere morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a haltere are generated and organized." [GOC:jid, GOC:rc]
is_a: GO:0035114 ! imaginal disc-derived appendage morphogenesis
is_a: GO:0035120 ! post-embryonic appendage morphogenesis
relationship: part_of GO:0007481 ! haltere disc morphogenesis
relationship: part_of GO:0007482 ! haltere development

[Term]
id: GO:0048736
name: appendage development
namespace: biological_process
def: "The process whose specific outcome is the progression of an appendage over time, from its formation to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch." [GOC:jid, GOC:rc]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007275 ! multicellular organism development

[Term]
id: GO:0048737
name: imaginal disc-derived appendage development
namespace: biological_process
def: "The process whose specific outcome is the progression of an appendage over time, from its formation in the imaginal disc to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism." [GOC:jid, GOC:mtg_sensu, GOC:rc]
is_a: GO:0048736 ! appendage development

[Term]
id: GO:0048738
name: cardiac muscle tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:lm]
synonym: "heart muscle development" EXACT []
is_a: GO:0014706 ! striated muscle tissue development
relationship: part_of GO:0007507 ! heart development

[Term]
id: GO:0048739
name: cardiac muscle fiber development
namespace: biological_process
def: "The process whose specific outcome is the progression of cardiac muscle fiber over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:lm]
synonym: "cardiac muscle fibre development" EXACT []
synonym: "heart muscle fiber development" RELATED []
is_a: GO:0048747 ! muscle fiber development
is_a: GO:0055013 ! cardiac muscle cell development
relationship: part_of GO:0048738 ! cardiac muscle tissue development

[Term]
id: GO:0048740
name: obsolete striated muscle fiber development
namespace: biological_process
def: "OBSOLETE. The process whose specific outcome is the amplification and progression of myoblasts (muscle precursor cells) into terminally differentiated multinucleated muscle fibers." [GOC:dph, GOC:jid, GOC:lm, GOC:mtg_muscle]
comment: This term was made obsolete because it was an unnecessary grouping term. Striated muscle comprises skeletal and cardiac muscle, but GO has opted not to group the muscle fiber development terms.
synonym: "myogenesis" EXACT []
synonym: "striated muscle fiber development" EXACT []
synonym: "striated muscle fibre development" EXACT []
is_obsolete: true

[Term]
id: GO:0048741
name: skeletal muscle fiber development
namespace: biological_process
def: "The process whose specific outcome is the progression of the skeletal muscle fiber over time, from its formation to the mature structure. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:ef, GOC:jid, GOC:lm, GOC:mtg_muscle]
synonym: "skeletal muscle fibre development" EXACT []
synonym: "skeletal myofiber development" EXACT []
synonym: "skeletal myofibre development" EXACT []
is_a: GO:0014904 ! myotube cell development
is_a: GO:0048747 ! muscle fiber development
relationship: part_of GO:0007519 ! skeletal muscle tissue development

[Term]
id: GO:0048742
name: regulation of skeletal muscle fiber development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:jid, GOC:mtg_muscle, GOC:sm]
synonym: "regulation of skeletal muscle fibre development" EXACT []
synonym: "regulation of skeletal myofiber development" EXACT []
synonym: "regulation of skeletal myofibre development" EXACT []
is_a: GO:0010830 ! regulation of myotube differentiation
is_a: GO:0048641 ! regulation of skeletal muscle tissue development
is_a: GO:0060284 ! regulation of cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048741 ! skeletal muscle fiber development
relationship: regulates GO:0048741 ! skeletal muscle fiber development

[Term]
id: GO:0048743
name: positive regulation of skeletal muscle fiber development
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:jid, GOC:lm, GOC:mtg_muscle]
synonym: "activation of skeletal muscle fiber development" NARROW []
synonym: "positive regulation of skeletal muscle fibre development" EXACT []
synonym: "positive regulation of skeletal myofiber development" EXACT []
synonym: "positive regulation of skeletal myofibre development" EXACT []
synonym: "stimulation of skeletal muscle fiber development" NARROW []
synonym: "up regulation of skeletal muscle fiber development" EXACT []
synonym: "up-regulation of skeletal muscle fiber development" EXACT []
synonym: "upregulation of skeletal muscle fiber development" EXACT []
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0010831 ! positive regulation of myotube differentiation
is_a: GO:0048643 ! positive regulation of skeletal muscle tissue development
is_a: GO:0048742 ! regulation of skeletal muscle fiber development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048741 ! skeletal muscle fiber development
relationship: positively_regulates GO:0048741 ! skeletal muscle fiber development

[Term]
id: GO:0048744
name: negative regulation of skeletal muscle fiber development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:jid, GOC:lm, GOC:mtg_muscle]
synonym: "down regulation of skeletal muscle fiber development" EXACT []
synonym: "down-regulation of skeletal muscle fiber development" EXACT []
synonym: "downregulation of skeletal muscle fiber development" EXACT []
synonym: "inhibition of skeletal muscle fiber development" NARROW []
synonym: "negative regulation of skeletal muscle fibre development" EXACT []
synonym: "negative regulation of skeletal myofiber development" EXACT []
synonym: "negative regulation of skeletal myofibre development" EXACT []
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0010832 ! negative regulation of myotube differentiation
is_a: GO:0048642 ! negative regulation of skeletal muscle tissue development
is_a: GO:0048742 ! regulation of skeletal muscle fiber development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048741 ! skeletal muscle fiber development
relationship: negatively_regulates GO:0048741 ! skeletal muscle fiber development

[Term]
id: GO:0048745
name: smooth muscle tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of smooth muscle over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:lm]
is_a: GO:0060537 ! muscle tissue development

[Term]
id: GO:0048746
name: obsolete smooth muscle fiber development
namespace: biological_process
def: "OBSOLETE. The process whose specific outcome is the progression of smooth muscle fiber over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:lm, GOC:mtg_muscle]
comment: This term was made obsolete because smooth muscle does not have fibers.
synonym: "smooth muscle fiber development" EXACT []
synonym: "smooth muscle fibre development" EXACT []
is_obsolete: true

[Term]
id: GO:0048747
name: muscle fiber development
namespace: biological_process
def: "The process whose specific outcome is the progression of the muscle fiber over time, from its formation to the mature structure. In skeletal muscle, fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:jid, GOC:lm, GOC:mtg_muscle]
synonym: "muscle fibre development" EXACT []
synonym: "myofiber development" EXACT []
synonym: "myofibre development" EXACT []
is_a: GO:0055002 ! striated muscle cell development

[Term]
id: GO:0048749
name: compound eye development
namespace: biological_process
alt_id: GO:0007456
def: "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
synonym: "insect-type retina development" EXACT [PMID:11735386]
is_a: GO:0001654 ! eye development

[Term]
id: GO:0048750
name: compound eye corneal lens morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the compound eye corneal lens are generated and organized." [GOC:jid]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0001745 ! compound eye morphogenesis
relationship: part_of GO:0048058 ! compound eye corneal lens development

[Term]
id: GO:0048752
name: semicircular canal morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the semicircular canals are generated and organized." [GOC:dgh, GOC:dph, GOC:jid]
synonym: "embryonic semicircular canal morphogenesis" EXACT []
is_a: GO:0035239 ! tube morphogenesis
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0042472 ! inner ear morphogenesis
relationship: part_of GO:0060872 ! semicircular canal development

[Term]
id: GO:0048753
name: pigment granule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pigment granule." [GOC:rc]
subset: goslim_pir
synonym: "pigment granule organisation" EXACT [GOC:curators]
synonym: "pigment granule organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0016050 ! vesicle organization
relationship: part_of GO:0033059 ! cellular pigmentation

[Term]
id: GO:0048754
name: branching morphogenesis of an epithelial tube
namespace: biological_process
def: "The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder." [GOC:dgh, GOC:dph, GOC:jid]
synonym: "tubulogenesis" RELATED [GOC:dph, GOC:tb]
is_a: GO:0035239 ! tube morphogenesis
is_a: GO:0061138 ! morphogenesis of a branching epithelium
relationship: part_of GO:0060562 ! epithelial tube morphogenesis

[Term]
id: GO:0048755
name: branching morphogenesis of a nerve
namespace: biological_process
def: "The process in which the anatomical structures of branches in a nerve are generated and organized. This term refers to an anatomical structure (nerve) not a cell (neuron)." [GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0001763 ! morphogenesis of a branching structure
relationship: part_of GO:0007399 ! nervous system development

[Term]
id: GO:0048756
name: sieve cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a sieve cell. A sieve cell is a type of sieve element that has relatively undifferentiated sieve areas (with narrow pores). The sieve areas are rather uniform in structure on all walls; that is, there are no sieve plates. Typical of gymnosperms and lower vascular plants. The sieve element is the cell in the phloem tissue concerned with mainly longitudinal conduction of food materials." [GOC:jid, PO:0025415, POC:curators]
is_a: GO:0090603 ! sieve element differentiation
relationship: part_of GO:0010088 ! phloem development

[Term]
id: GO:0048757
name: pigment granule maturation
namespace: biological_process
def: "Steps required to form a membrane-bounded organelle into a pigment granule containing pigment. Maturation is a developmental process, independent of morphogenetic (shape) change, that is required for a cell or structure to attain its fully functional state." [GOC:dgh, GOC:jid, GOC:mh]
is_a: GO:0021700 ! developmental maturation
is_a: GO:0043482 ! cellular pigment accumulation
relationship: part_of GO:0050931 ! pigment cell differentiation

[Term]
id: GO:0048758
name: companion cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a companion cell. The companion cell is the specialized parenchyma cell associated with a sieve-tube member in angiosperm phloem and arising from the same mother cell as the sieve-tube member." [CL:0000284, GOC:jid]
is_a: GO:0048760 ! plant parenchymal cell differentiation
relationship: part_of GO:0010088 ! phloem development

[Term]
id: GO:0048759
name: xylem vessel member cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a vessel member cell. A vessel member cell is one of the components of a vessel in the xylem. It is a dead cell with the wall between adjacent members being variously perforated and the walls that persist variously thickened." [GOC:jid, PO:0002003]
synonym: "vessel element cell differentiation" BROAD []
synonym: "vessel member cell differentiation" BROAD []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0010089 ! xylem development

[Term]
id: GO:0048760
name: plant parenchymal cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a parenchymal cell. Parenchymal cells are the most abundant and versatile cells in plants. They have very few distinguishing characteristics and botanists classify them as any cell type that cannot be assigned to any other structural or functional class. They can redifferentiate and dedifferentiate and are involved in storage, basic metabolism and other processes. The cells are polyhedral, typically with thin, non-lignified cellulose cell walls and nucleate living protoplasm. They vary in size, form, and wall structure." [CL:0000668, GOC:jid, ISBN:069716957X, PO:0005421]
synonym: "parenchymal cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0048761
name: collenchyma cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a collenchyma cell. This is a plant cell in which the primary cell walls are unevenly thickened, with most thickening occurring at the cell corners. Cells are living and able to grow, they are elongated, and lignin and secondary walls absent. Collenchyma cells make up collenchyma tissue which acts as a supporting tissue in growing shoots, leaves and petioles. This tissue is often arranged in cortical ribs, as seen prominently in celery and rhubarb petioles." [CL:0000330, GOC:jid, PO:0000075]
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0048762
name: mesenchymal cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types." [GOC:dph, GOC:jid]
is_a: GO:0048863 ! stem cell differentiation
relationship: part_of GO:0060485 ! mesenchyme development

[Term]
id: GO:0048763
name: calcium-induced calcium release activity
namespace: molecular_function
def: "Enables transmembrane transfer of calcium ions from an intracellular store to the cytosol on induction by increased calcium concentration." [GOC:jid, GOC:nln, PMID:2990997, PMID:8381210, PMID:8653752]
is_a: GO:0015278 ! calcium-release channel activity

[Term]
id: GO:0048764
name: trichoblast maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a trichoblast cell to attain its fully functional state." [GOC:jid]
is_a: GO:0048469 ! cell maturation
relationship: part_of GO:0010054 ! trichoblast differentiation

[Term]
id: GO:0048765
name: root hair cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a root hair cell." [GOC:jid]
is_a: GO:0010053 ! root epidermal cell differentiation
is_a: GO:0048764 ! trichoblast maturation

[Term]
id: GO:0048766
name: root hair initiation
namespace: biological_process
def: "The process in which a protrusion or bulge is formed at the site of plant root hair outgrowth." [GOC:jid, PMID:12468740]
is_a: GO:0000904 ! cell morphogenesis involved in differentiation
relationship: part_of GO:0048765 ! root hair cell differentiation

[Term]
id: GO:0048767
name: root hair elongation
namespace: biological_process
def: "The process in which the root hair grows longer." [GOC:jid, PMID:12468740]
is_a: GO:0048588 ! developmental cell growth
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0080147 ! root hair cell development

[Term]
id: GO:0048768
name: root hair cell tip growth
namespace: biological_process
def: "Localized growth of a plant root hair tip by extension of the cell wall." [GOC:jid, GOC:ki, PMID:12468740]
synonym: "root hair tip growth" EXACT []
is_a: GO:0000904 ! cell morphogenesis involved in differentiation
is_a: GO:0009932 ! cell tip growth
relationship: part_of GO:0048767 ! root hair elongation

[Term]
id: GO:0048769
name: sarcomerogenesis
namespace: biological_process
def: "The process in which sarcomeres are added in series within a fiber." [GOC:jid, GOC:lm, PMID:15947030]
synonym: "myofibril production" EXACT systematic_synonym []
is_a: GO:0031032 ! actomyosin structure organization
relationship: part_of GO:0030239 ! myofibril assembly

[Term]
id: GO:0048770
name: pigment granule
namespace: cellular_component
def: "A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes." [GOC:jid, GOC:mh]
is_a: GO:0016023 ! cytoplasmic, membrane-bounded vesicle

[Term]
id: GO:0048771
name: tissue remodeling
namespace: biological_process
def: "The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling." [GOC:ebc]
subset: goslim_pir
is_a: GO:0044707 ! single-multicellular organism process

[Term]
id: GO:0048772
name: leucophore differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a leucophore cell. Leucophores are pigment cells derived from the neural crest. They contain uric acid or other purine crystals, deposited in stacks called leucosomes. This gives them a white appearance." [GOC:jid, GOC:mh]
synonym: "leucophore cell differentiation" EXACT []
is_a: GO:0050931 ! pigment cell differentiation

[Term]
id: GO:0048773
name: erythrophore differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of an erythrophore cell. Erythrophores are pigment cells derived from the neural crest. They contain pteridine and/or carotenoid pigments in structures called pterinosomes or erythrosomes. This gives them an orange to red appearance." [GOC:jid, GOC:mh]
synonym: "erythrophore cell differentiation" EXACT []
is_a: GO:0050931 ! pigment cell differentiation

[Term]
id: GO:0048774
name: cyanophore differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a cyanophore cell. Cyanophores are pigment cells derived from the neural crest. They contain a blue pigment of unknown chemical composition. The pigment is stored in fibrous organelles termed cyanosomes." [GOC:jid, GOC:mh]
synonym: "cyanophore cell differentiation" EXACT []
is_a: GO:0050931 ! pigment cell differentiation

[Term]
id: GO:0048775
name: regulation of leucophore differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of leucophore differentiation." [GOC:mh]
is_a: GO:0050932 ! regulation of pigment cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048772 ! leucophore differentiation
relationship: regulates GO:0048772 ! leucophore differentiation

[Term]
id: GO:0048776
name: negative regulation of leucophore differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of leucophore differentiation." [GOC:mh]
synonym: "down regulation of leucophore differentiation" EXACT []
synonym: "down-regulation of leucophore differentiation" EXACT []
synonym: "downregulation of leucophore differentiation" EXACT []
synonym: "inhibition of leucophore differentiation" NARROW []
is_a: GO:0048775 ! regulation of leucophore differentiation
is_a: GO:0050941 ! negative regulation of pigment cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048772 ! leucophore differentiation
relationship: negatively_regulates GO:0048772 ! leucophore differentiation

[Term]
id: GO:0048777
name: positive regulation of leucophore differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of leucophore differentiation." [GOC:mh]
synonym: "activation of leucophore differentiation" NARROW []
synonym: "stimulation of leucophore differentiation" NARROW []
synonym: "up regulation of leucophore differentiation" EXACT []
synonym: "up-regulation of leucophore differentiation" EXACT []
synonym: "upregulation of leucophore differentiation" EXACT []
is_a: GO:0048775 ! regulation of leucophore differentiation
is_a: GO:0050942 ! positive regulation of pigment cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048772 ! leucophore differentiation
relationship: positively_regulates GO:0048772 ! leucophore differentiation

[Term]
id: GO:0048778
name: regulation of erythrophore differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of erythrophore differentiation." [GOC:mh]
is_a: GO:0050932 ! regulation of pigment cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048773 ! erythrophore differentiation
relationship: regulates GO:0048773 ! erythrophore differentiation

[Term]
id: GO:0048779
name: negative regulation of erythrophore differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of erythrophore differentiation." [GOC:mh]
synonym: "down regulation of erythrophore differentiation" EXACT []
synonym: "down-regulation of erythrophore differentiation" EXACT []
synonym: "downregulation of erythrophore differentiation" EXACT []
synonym: "inhibition of erythrophore differentiation" NARROW []
is_a: GO:0048778 ! regulation of erythrophore differentiation
is_a: GO:0050941 ! negative regulation of pigment cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048773 ! erythrophore differentiation
relationship: negatively_regulates GO:0048773 ! erythrophore differentiation

[Term]
id: GO:0048780
name: positive regulation of erythrophore differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of erythrophore differentiation." [GOC:mh]
synonym: "activation of erythrophore differentiation" NARROW []
synonym: "stimulation of erythrophore differentiation" NARROW []
synonym: "up regulation of erythrophore differentiation" EXACT []
synonym: "up-regulation of erythrophore differentiation" EXACT []
synonym: "upregulation of erythrophore differentiation" EXACT []
is_a: GO:0048778 ! regulation of erythrophore differentiation
is_a: GO:0050942 ! positive regulation of pigment cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048773 ! erythrophore differentiation
relationship: positively_regulates GO:0048773 ! erythrophore differentiation

[Term]
id: GO:0048781
name: regulation of cyanophore differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cyanophore differentiation." [GOC:mh]
is_a: GO:0050932 ! regulation of pigment cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048774 ! cyanophore differentiation
relationship: regulates GO:0048774 ! cyanophore differentiation

[Term]
id: GO:0048782
name: negative regulation of cyanophore differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cyanophore differentiation." [GOC:mh]
synonym: "down regulation of cyanophore differentiation" EXACT []
synonym: "down-regulation of cyanophore differentiation" EXACT []
synonym: "downregulation of cyanophore differentiation" EXACT []
synonym: "inhibition of cyanophore differentiation" NARROW []
is_a: GO:0048781 ! regulation of cyanophore differentiation
is_a: GO:0050941 ! negative regulation of pigment cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048774 ! cyanophore differentiation
relationship: negatively_regulates GO:0048774 ! cyanophore differentiation

[Term]
id: GO:0048783
name: positive regulation of cyanophore differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cyanophore differentiation." [GOC:mh]
synonym: "activation of cyanophore differentiation" NARROW []
synonym: "stimulation of cyanophore differentiation" NARROW []
synonym: "up regulation of cyanophore differentiation" EXACT []
synonym: "up-regulation of cyanophore differentiation" EXACT []
synonym: "upregulation of cyanophore differentiation" EXACT []
is_a: GO:0048781 ! regulation of cyanophore differentiation
is_a: GO:0050942 ! positive regulation of pigment cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048774 ! cyanophore differentiation
relationship: positively_regulates GO:0048774 ! cyanophore differentiation

[Term]
id: GO:0048784
name: pigment biosynthetic process involved in pigment granule maturation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a pigment, contributing to the process in which a membrane-bounded organelle develops into a pigment granule. Maturation is a developmental process, independent of morphogenetic (shape) change, that is required for a cell or structure to attain its fully functional state." [GOC:jid]
synonym: "pigment biosynthetic process during pigment granule maturation" RELATED [GOC:dph, GOC:tb]
is_a: GO:0043324 ! pigment metabolic process involved in developmental pigmentation
is_a: GO:0043477 ! pigment biosynthetic process involved in pigment accumulation
intersection_of: GO:0046148 ! pigment biosynthetic process
intersection_of: part_of GO:0048757 ! pigment granule maturation
relationship: part_of GO:0048757 ! pigment granule maturation

[Term]
id: GO:0048785
name: hatching gland development
namespace: biological_process
def: "The process whose specific outcome is the progression of the hatching gland over time, from its formation to the mature structure. The cells of the hatching gland contain enzymes responsible for solubilization of the egg chorion, facilitating the hatching process." [GOC:bf, GOC:dh, GOC:jid]
is_a: GO:0048732 ! gland development

[Term]
id: GO:0048786
name: presynaptic active zone
namespace: cellular_component
def: "A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix." [GOC:dh, GOC:dl, GOC:ef, GOC:jid, GOC:pr, PMID:3152289]
subset: goslim_synapse
synonym: "pre-synaptic active zone" EXACT []
synonym: "pre-synaptic active zone component" NARROW [NIF_Subcellular:sao1911631652]
xref: NIF_Subcellular:sao792027222
is_a: GO:0044456 ! synapse part
is_a: GO:0097458 ! neuron part
relationship: part_of GO:0098793 ! presynapse

[Term]
id: GO:0048787
name: presynaptic active zone membrane
namespace: cellular_component
def: "The membrane portion of the presynaptic active zone; it is the site where docking and fusion of synaptic vesicles occurs for the release of neurotransmitters." [PMID:12812759, PMID:12923177, PMID:3152289]
subset: goslim_synapse
synonym: "active zone plasma membrane" EXACT [NIF_Subcellular:sao2038461087]
synonym: "active zone pre-synaptic plasma membrane" EXACT []
synonym: "active zone presynaptic plasma membrane" EXACT []
synonym: "pre-synaptic active zone membrane" EXACT []
xref: NIF_Subcellular:sao2038461087
is_a: GO:0097060 ! synaptic membrane
is_a: GO:0097458 ! neuron part
intersection_of: GO:0016020 ! membrane
intersection_of: part_of GO:0042734 ! presynaptic membrane
intersection_of: part_of GO:0048786 ! presynaptic active zone
relationship: part_of GO:0042734 ! presynaptic membrane
relationship: part_of GO:0048786 ! presynaptic active zone

[Term]
id: GO:0048788
name: cytoskeleton of presynaptic active zone
namespace: cellular_component
def: "The specialized cytoskeletal matrix of the presynaptic active zone. It has specialized functions in organizing synaptic events such as immobilisation or translocation of synaptic vesicles, and assembling active zone components. It is believed to form a molecular scaffold that organizes neurotransmitter release sites." [GOC:dh, GOC:dl, GOC:ef, GOC:jid, NIF_Subcellular:sao1470121605, PMID:10944438]
subset: goslim_synapse
synonym: "active zone cytomatrix" EXACT []
synonym: "CAZ" NARROW []
synonym: "pre-synaptic cytoskeletal matrix assembled at active zones" RELATED []
synonym: "pre-synaptic dense body" NARROW [NIF_Subcellular:sao1111202255, PMID:12575947]
synonym: "pre-synaptic ribbon" RELATED [ISBN:0716723808, NIF_Subcellular:sao-1488888179, NIF_Subcellular:sao1488888179]
synonym: "presynaptic cytomatrix assembled at active zones" EXACT []
synonym: "presynaptic cytoskeletal matrix assembled at active zones" EXACT []
synonym: "presynaptic dense body" NARROW [PMID:16709774]
synonym: "presynaptic ribbon" RELATED [ISBN:0716723808, NIF_Subcellular:sao1488888179]
synonym: "ribbon" RELATED [NIF_Subcellular:sao1111202255, PMID:12575947]
synonym: "synaptic ribbon" NARROW [PMID:19264728]
synonym: "T-bar" NARROW [PMID:20127822]
synonym: "T-bar ribbon" NARROW [PMID:16384719]
xref: NIF_Subcellular:sao1470121605
is_a: GO:0030863 ! cortical cytoskeleton
is_a: GO:0099569 ! presynaptic cytoskeleton
intersection_of: GO:0030863 ! cortical cytoskeleton
intersection_of: part_of GO:0098831 ! presynaptic active zone cytoplasmic component
relationship: part_of GO:0048786 ! presynaptic active zone
relationship: part_of GO:0098831 ! presynaptic active zone cytoplasmic component

[Term]
id: GO:0048789
name: cytoskeletal matrix organization at active zone
namespace: biological_process
def: "The assembly and arrangement of cytomatrix proteins to form complexes in the cell cortex beneath the active zone, i.e. just beneath the presynaptic plasma membrane." [GOC:dh, GOC:ef, GOC:jid, PMID:12812759]
synonym: "cytoskeletal matrix organisation at active zone" EXACT [GOC:mah]
is_a: GO:0030865 ! cortical cytoskeleton organization

[Term]
id: GO:0048790
name: maintenance of presynaptic active zone structure
namespace: biological_process
def: "A process which maintains the organization and the arrangement of proteins at the active zone to ensure the fusion and docking of vesicles and the release of neurotransmitters." [GOC:curators, GOC:dph, GOC:pr]
subset: goslim_synapse
synonym: "maintenance of pre-synaptic active zone structure" EXACT []
is_a: GO:0099558 ! maintenance of synapse structure
is_a: GO:1990709 ! presynaptic active zone organization

[Term]
id: GO:0048791
name: calcium ion-regulated exocytosis of neurotransmitter
namespace: biological_process
def: "The release of a neurotransmitter into the synaptic cleft by exocytosis of synaptic vesicles, where the release step is dependent on a rise in cytosolic calcium ion levels. " [GOC:curators]
is_a: GO:0016079 ! synaptic vesicle exocytosis
relationship: occurs_in GO:0098793 ! presynapse
relationship: part_of GO:0007268 ! synaptic transmission

[Term]
id: GO:0048792
name: spontaneous exocytosis of neurotransmitter
namespace: biological_process
def: "The release of a neurotransmitter into the synaptic cleft, where the release step is independent of the presence of calcium ions (Ca2+). The neurotransmitter is contained within a membrane-bounded vesicle, and is released by fusion of the vesicle with the presynaptic plasma membrane of a nerve cell." [GOC:curators]
synonym: "spontaneous synaptic vesicle exocytosis" EXACT []
is_a: GO:0007269 ! neurotransmitter secretion
is_a: GO:0016079 ! synaptic vesicle exocytosis

[Term]
id: GO:0048793
name: pronephros development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pronephros over time, from its formation to the mature structure. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life." [GOC:bf, GOC:mtg_kidney_jan10, PMID:10535314, PMID:15968585, PMID:18322540, XAO:00002000, ZFA:0000151]
synonym: "pronephric kidney development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0001822 ! kidney development

[Term]
id: GO:0048794
name: swim bladder development
namespace: biological_process
def: "The process whose specific outcome is the progression of the swim bladder over time, from its formation to the mature structure. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ." [GOC:mh]
synonym: "gas bladder development" EXACT []
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048513 ! animal organ development

[Term]
id: GO:0048795
name: swim bladder morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the swim bladder is generated and organized. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ." [GOC:mh]
synonym: "gas bladder morphogenesis" EXACT []
is_a: GO:0009887 ! organ morphogenesis
relationship: part_of GO:0048794 ! swim bladder development

[Term]
id: GO:0048796
name: swim bladder maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a swim bladder to attain its fully functional state. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ." [GOC:devbiol]
synonym: "gas bladder maturation" EXACT []
is_a: GO:0048799 ! organ maturation
relationship: part_of GO:0048794 ! swim bladder development

[Term]
id: GO:0048797
name: swim bladder formation
namespace: biological_process
def: "The process that gives rise to the swim bladder. This process pertains to the initial formation of a structure from unspecified parts. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ." [GOC:mh]
synonym: "gas bladder biosynthesis" EXACT []
synonym: "gas bladder formation" EXACT []
is_a: GO:0048645 ! organ formation
relationship: part_of GO:0048795 ! swim bladder morphogenesis

[Term]
id: GO:0048798
name: swim bladder inflation
namespace: biological_process
def: "The expansion of the swim bladder by trapped gases. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ." [GOC:mh]
synonym: "gas bladder inflation" EXACT []
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0048796 ! swim bladder maturation

[Term]
id: GO:0048799
name: organ maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for an organ to attain its fully functional state. An organ is a tissue or set of tissues that work together to perform a specific function or functions." [GOC:curators]
is_a: GO:0071695 ! anatomical structure maturation
relationship: part_of GO:0048513 ! animal organ development

[Term]
id: GO:0048800
name: antennal morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the antenna are generated and organized." [GOC:jid]
is_a: GO:0009886 ! post-embryonic morphogenesis
is_a: GO:0035107 ! appendage morphogenesis
relationship: part_of GO:0007455 ! eye-antennal disc morphogenesis
relationship: part_of GO:0007469 ! antennal development

[Term]
id: GO:0048801
name: antennal joint morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the antennal joint are generated and organized." [GOC:jid]
is_a: GO:0009886 ! post-embryonic morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0048098 ! antennal joint development
relationship: part_of GO:0048800 ! antennal morphogenesis

[Term]
id: GO:0048802
name: notum morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the dorsal part of the body are generated and organized." [GOC:jid]
is_a: GO:0009886 ! post-embryonic morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0007472 ! wing disc morphogenesis
relationship: part_of GO:0007477 ! notum development

[Term]
id: GO:0048803
name: imaginal disc-derived male genitalia morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of male genitalia are generated and organized from the genital imaginal disc." [GOC:ai, GOC:sensu]
synonym: "male genital morphogenesis" BROAD []
is_a: GO:0048805 ! imaginal disc-derived genitalia morphogenesis
is_a: GO:0048808 ! male genitalia morphogenesis
relationship: part_of GO:0007485 ! imaginal disc-derived male genitalia development

[Term]
id: GO:0048804
name: imaginal disc-derived female genitalia morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of female genitalia are generated and organized from the genital disc." [GOC:ai, GOC:sensu]
synonym: "female genital morphogenesis" BROAD []
is_a: GO:0048805 ! imaginal disc-derived genitalia morphogenesis
is_a: GO:0048807 ! female genitalia morphogenesis
relationship: part_of GO:0007486 ! imaginal disc-derived female genitalia development

[Term]
id: GO:0048805
name: imaginal disc-derived genitalia morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of genitalia are generated and organized from the genital imaginal disc." [GOC:ai, GOC:sensu]
synonym: "genital morphogenesis" BROAD []
is_a: GO:0035126 ! post-embryonic genitalia morphogenesis
relationship: part_of GO:0007483 ! genital disc morphogenesis
relationship: part_of GO:0007484 ! imaginal disc-derived genitalia development

[Term]
id: GO:0048806
name: genitalia development
namespace: biological_process
def: "The process whose specific outcome is the progression of the genitalia over time, from its formation to the mature structure." [GOC:jid]
synonym: "genital development" EXACT []
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048513 ! animal organ development
is_a: GO:0048608 ! reproductive structure development
is_a: GO:0048731 ! system development
relationship: part_of GO:0007548 ! sex differentiation

[Term]
id: GO:0048807
name: female genitalia morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of female genitalia are generated and organized." [GOC:mah]
synonym: "female genital morphogenesis" RELATED []
is_a: GO:0035112 ! genitalia morphogenesis
relationship: part_of GO:0030540 ! female genitalia development

[Term]
id: GO:0048808
name: male genitalia morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of male genitalia are generated and organized." [GOC:ems, ISBN:0140512888]
synonym: "male genital morphogenesis" RELATED []
is_a: GO:0035112 ! genitalia morphogenesis
is_a: GO:0090598 ! male anatomical structure morphogenesis
relationship: part_of GO:0030539 ! male genitalia development

[Term]
id: GO:0048809
name: analia morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of analia are generated and organized. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is analia morphogenesis in Drosophila melanogaster." [GOC:ai, GOC:mtg_sensu]
is_a: GO:0009886 ! post-embryonic morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0007483 ! genital disc morphogenesis
relationship: part_of GO:0007487 ! analia development

[Term]
id: GO:0048810
name: female analia morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the analia of the female are generated and organized. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11494318]
is_a: GO:0048809 ! analia morphogenesis
relationship: part_of GO:0045497 ! female analia development

[Term]
id: GO:0048811
name: male analia morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the analia of the male are generated and organized. The analia is the posterior-most vertral appendage that develops from the genital disc." [GOC:mtg_sensu, PMID:11494318]
is_a: GO:0048809 ! analia morphogenesis
relationship: part_of GO:0045496 ! male analia development

[Term]
id: GO:0048812
name: neuron projection morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
synonym: "neurite biosynthesis" NARROW []
synonym: "neurite formation" NARROW []
synonym: "neurite growth" NARROW []
synonym: "neurite morphogenesis" RELATED [GOC:dph, GOC:tb]
is_a: GO:0048858 ! cell projection morphogenesis
relationship: part_of GO:0031175 ! neuron projection development

[Term]
id: GO:0048813
name: dendrite morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
is_a: GO:0048812 ! neuron projection morphogenesis
relationship: part_of GO:0016358 ! dendrite development
relationship: part_of GO:0048667 ! cell morphogenesis involved in neuron differentiation

[Term]
id: GO:0048814
name: regulation of dendrite morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dendrite morphogenesis." [GOC:ai]
is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation
is_a: GO:0050773 ! regulation of dendrite development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048813 ! dendrite morphogenesis
relationship: regulates GO:0048813 ! dendrite morphogenesis

[Term]
id: GO:0048815
name: hermaphrodite genitalia morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of hermaphrodite genitalia are generated and organized." [GOC:ems, ISBN:0140512888]
is_a: GO:0035112 ! genitalia morphogenesis
is_a: GO:0035262 ! gonad morphogenesis
relationship: part_of GO:0040035 ! hermaphrodite genitalia development

[Term]
id: GO:0048816
name: ocellus morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the ocellus are generated and organized. The ocellus is a simple visual organ of insects." [http://fly.ebi.ac.uk/.bin/cvreport2?id=FBcv0004540]
is_a: GO:0009886 ! post-embryonic morphogenesis
is_a: GO:0090596 ! sensory organ morphogenesis
relationship: part_of GO:0007455 ! eye-antennal disc morphogenesis
relationship: part_of GO:0008056 ! ocellus development

[Term]
id: GO:0048817
name: negative regulation of hair follicle maturation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of hair follicle maturation." [GOC:devbiol]
synonym: "down regulation of hair follicle maturation" EXACT []
synonym: "down-regulation of hair follicle maturation" EXACT []
synonym: "downregulation of hair follicle maturation" EXACT []
synonym: "inhibition of hair follicle maturation" NARROW []
is_a: GO:0048819 ! regulation of hair follicle maturation
is_a: GO:0051799 ! negative regulation of hair follicle development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048820 ! hair follicle maturation
relationship: negatively_regulates GO:0048820 ! hair follicle maturation

[Term]
id: GO:0048818
name: positive regulation of hair follicle maturation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hair follicle maturation." [GOC:devbiol]
synonym: "activation of hair follicle maturation" NARROW []
synonym: "stimulation of hair follicle maturation" NARROW []
synonym: "up regulation of hair follicle maturation" EXACT []
synonym: "up-regulation of hair follicle maturation" EXACT []
synonym: "upregulation of hair follicle maturation" EXACT []
is_a: GO:0048819 ! regulation of hair follicle maturation
is_a: GO:0051798 ! positive regulation of hair follicle development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048820 ! hair follicle maturation
relationship: positively_regulates GO:0048820 ! hair follicle maturation

[Term]
id: GO:0048819
name: regulation of hair follicle maturation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hair follicle maturation." [GOC:devbiol]
is_a: GO:0051797 ! regulation of hair follicle development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048820 ! hair follicle maturation
relationship: regulates GO:0048820 ! hair follicle maturation

[Term]
id: GO:0048820
name: hair follicle maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a hair follicle to attain its fully functional state." [GOC:devbiol]
is_a: GO:0022405 ! hair cycle process
is_a: GO:0071695 ! anatomical structure maturation
relationship: part_of GO:0001942 ! hair follicle development

[Term]
id: GO:0048821
name: erythrocyte development
namespace: biological_process
def: "The process whose specific outcome is the progression of an erythrocyte over time, from its formation to the mature structure." [GOC:devbiol]
synonym: "RBC development" EXACT [CL:0000232]
synonym: "red blood cell development" EXACT [CL:0000232]
is_a: GO:0061515 ! myeloid cell development
relationship: part_of GO:0030218 ! erythrocyte differentiation

[Term]
id: GO:0048822
name: enucleate erythrocyte development
namespace: biological_process
def: "The process aimed at the progression of an enucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:devbiol]
synonym: "enucleate RBC development" EXACT [CL:0000232]
synonym: "enucleate red blood cell development" EXACT [CL:0000232]
is_a: GO:0048821 ! erythrocyte development
relationship: part_of GO:0043353 ! enucleate erythrocyte differentiation

[Term]
id: GO:0048823
name: nucleate erythrocyte development
namespace: biological_process
def: "The process aimed at the progression of a nucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:devbiol]
synonym: "nucleate RBC development" EXACT [CL:0000232]
synonym: "nucleate red blood cell development" EXACT [CL:0000232]
is_a: GO:0048821 ! erythrocyte development
relationship: part_of GO:0043363 ! nucleate erythrocyte differentiation

[Term]
id: GO:0048824
name: pigment cell precursor differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a pigment cell precursor." [GOC:dgh, PMID:16499899]
synonym: "chromatophore precursor differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0048825
name: cotyledon development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cotyledon over time, from its formation to the mature structure. The cotyledon is the modified leaf (seed leaf), found as part of the embryo in plant seeds. It is involved in either storage or absorption of food reserves. Dicotyledonous seeds contain two cotyledons, while monocotyledonous seeds contain only one. The cotyledons may appear above ground and show photosynthetic activity in the seedling." [GOC:devbiol, GOC:tb, PO:0020030]
is_a: GO:0009793 ! embryo development ending in seed dormancy
is_a: GO:0048366 ! leaf development

[Term]
id: GO:0048826
name: cotyledon morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the cotyledon are generated and organized. The cotyledon is the modified leaf (seed leaf), found as part of the embryo in plant seeds. It is involved in either storage or absorption of food reserves. Dicotyledonous seeds contain two cotyledons, while monocotyledonous seeds contain only one. The cotyledons may appear above ground and show photosynthetic activity in the seedling." [GOC:devbiol, GOC:tb, PO:0020030]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0009886 ! post-embryonic morphogenesis
is_a: GO:0009965 ! leaf morphogenesis
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0048825 ! cotyledon development

[Term]
id: GO:0048827
name: phyllome development
namespace: biological_process
def: "The process whose specific outcome is the progression of a phyllome over time, from its formation to the mature structure. A phyllome is a collective term for all the different types of leaves appearing on plants." [GOC:devbiol, GOC:tb, PO:0006001]
is_a: GO:0099402 ! plant organ development
relationship: part_of GO:0048367 ! shoot system development

[Term]
id: GO:0048829
name: root cap development
namespace: biological_process
def: "The process whose specific outcome is the progression of the root cap over time, from its formation to the mature structure. The root cap protects the root meristem from friction as the root grows through the soil. The cap is made up of a group of parenchyma cells which secrete a glycoprotein mucilage as a lubricant." [GOC:tb]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048364 ! root development

[Term]
id: GO:0048830
name: adventitious root development
namespace: biological_process
def: "The process whose specific outcome is the progression of adventitious root over time, from its formation to the mature structure. Adventitious roots are post-embryonic roots that develop from the plant shoot." [GOC:tb]
is_a: GO:0048364 ! root development

[Term]
id: GO:0048831
name: regulation of shoot system development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of shoot development." [GOC:tb, PMID:16361392]
synonym: "regulation of shoot development" EXACT []
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048367 ! shoot system development
relationship: regulates GO:0048367 ! shoot system development

[Term]
id: GO:0048832
name: specification of organ number
namespace: biological_process
def: "The regionalization process that modulates the quantity of a particular type of organ." [GOC:dph, GOC:isa_complete, GOC:tb]
is_a: GO:0003002 ! regionalization
is_a: GO:0050793 ! regulation of developmental process

[Term]
id: GO:0048833
name: specification of floral organ number
namespace: biological_process
def: "Any process that modulates the number of floral organs formed in a floral whorl." [GOC:tb]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0048832 ! specification of organ number
relationship: part_of GO:0009908 ! flower development

[Term]
id: GO:0048834
name: specification of petal number
namespace: biological_process
def: "Any process that modulates the number of petals formed in a flower." [GOC:tb]
is_a: GO:0048833 ! specification of floral organ number
relationship: part_of GO:0048465 ! corolla development

[Term]
id: GO:0048835
name: specification of decreased petal number
namespace: biological_process
def: "Any process that reduces the number of petals produced in a developing flower." [GOC:tb]
is_a: GO:0048834 ! specification of petal number

[Term]
id: GO:0048836
name: specification of increased petal number
namespace: biological_process
def: "Any process that increases the number of petals produced in a developing flower." [GOC:tb]
is_a: GO:0048834 ! specification of petal number

[Term]
id: GO:0048837
name: sorus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the sorus over time, from its formation to the mature structure. A sorus is a mass of spores." [dictyBase_REF:2530, GOC:devbiol, GOC:mtg_sensu]
synonym: "sorus biosynthesis" EXACT []
synonym: "sorus formation" EXACT []
synonym: "spore head biosynthesis" EXACT []
synonym: "spore head formation" EXACT []
synonym: "spore head morphogenesis" EXACT []
is_a: GO:0048608 ! reproductive structure development
relationship: part_of GO:0031154 ! culmination involved in sorocarp development

[Term]
id: GO:0048838
name: release of seed from dormancy
namespace: biological_process
def: "The process in which the dormant state is broken in a seed. Dormancy is characterized by a suspension of physiological activity that can be reactivated upon release." [GOC:dph, GOC:jid, GOC:tb, ISBN:9781405139830]
is_a: GO:0010162 ! seed dormancy process
is_a: GO:0097438 ! exit from dormancy

[Term]
id: GO:0048839
name: inner ear development
namespace: biological_process
def: "The process whose specific outcome is the progression of the inner ear over time, from its formation to the mature structure." [GOC:sr]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0043583 ! ear development

[Term]
id: GO:0048840
name: otolith development
namespace: biological_process
def: "The process whose specific outcome is the progression of the otolith over time, from its formation to the mature structure." [GOC:sr]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048839 ! inner ear development

[Term]
id: GO:0048841
name: regulation of axon extension involved in axon guidance
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of axon extension involved in axon guidance." [GOC:devbiol]
is_a: GO:0030516 ! regulation of axon extension
is_a: GO:1902667 ! regulation of axon guidance
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048846 ! axon extension involved in axon guidance
relationship: regulates GO:0048846 ! axon extension involved in axon guidance

[Term]
id: GO:0048842
name: positive regulation of axon extension involved in axon guidance
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of axon extension involved in axon guidance." [GOC:devbiol]
synonym: "activation of axon extension involved in axon guidance" NARROW []
synonym: "stimulation of axon extension involved in axon guidance" NARROW []
synonym: "up regulation of axon extension involved in axon guidance" EXACT []
synonym: "up-regulation of axon extension involved in axon guidance" EXACT []
synonym: "upregulation of axon extension involved in axon guidance" EXACT []
is_a: GO:0045773 ! positive regulation of axon extension
is_a: GO:0048841 ! regulation of axon extension involved in axon guidance
is_a: GO:1902669 ! positive regulation of axon guidance
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048846 ! axon extension involved in axon guidance
relationship: positively_regulates GO:0048846 ! axon extension involved in axon guidance

[Term]
id: GO:0048843
name: negative regulation of axon extension involved in axon guidance
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of axon extension involved in axon guidance." [GOC:devbiol]
synonym: "down regulation of axon extension involved in axon guidance" EXACT []
synonym: "down-regulation of axon extension involved in axon guidance" EXACT []
synonym: "downregulation of axon extension involved in axon guidance" EXACT []
synonym: "inhibition of axon extension involved in axon guidance" NARROW []
is_a: GO:0030517 ! negative regulation of axon extension
is_a: GO:0048841 ! regulation of axon extension involved in axon guidance
is_a: GO:1902668 ! negative regulation of axon guidance
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048846 ! axon extension involved in axon guidance
relationship: negatively_regulates GO:0048846 ! axon extension involved in axon guidance

[Term]
id: GO:0048844
name: artery morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of arterial blood vessels are generated and organized. Arteries are blood vessels that transport blood from the heart to the body and its organs." [GOC:dsf, PMID:16740480]
synonym: "arterial morphogenesis" EXACT []
synonym: "arteriogenesis" EXACT [GOC:mtg_heart]
is_a: GO:0048514 ! blood vessel morphogenesis
relationship: part_of GO:0060840 ! artery development

[Term]
id: GO:0048845
name: venous blood vessel morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of venous blood vessels are generated and organized. Veins are blood vessels that transport blood from the body and its organs to the heart." [GOC:dsf, PMID:16740480]
synonym: "vein morphogenesis" BROAD []
synonym: "venous morphogenesis" EXACT []
is_a: GO:0048514 ! blood vessel morphogenesis
relationship: part_of GO:0060841 ! venous blood vessel development

[Term]
id: GO:0048846
name: axon extension involved in axon guidance
namespace: biological_process
def: "The long distance growth of a single cell process, that is involved in the migration of an axon growth cone, where the migration is directed to a specific target site by a combination of attractive and repulsive cues." [GOC:ef, GOC:jid]
is_a: GO:0048675 ! axon extension
is_a: GO:1902284 ! neuron projection extension involved in neuron projection guidance
intersection_of: GO:0048675 ! axon extension
intersection_of: part_of GO:0007411 ! axon guidance
relationship: part_of GO:0007411 ! axon guidance

[Term]
id: GO:0048847
name: adenohypophysis formation
namespace: biological_process
def: "The process that gives rise to adenohypophysis. This process pertains to the initial formation of a structure from unspecified parts. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus." [GOC:cvs, GOC:dgh, GOC:dph, GOC:jid]
synonym: "adenophysis biosynthesis" EXACT []
synonym: "adenophysis formation" EXACT []
synonym: "anterior pituitary biosynthesis" EXACT []
synonym: "anterior pituitary formation" EXACT []
synonym: "anterior pituitary gland biosynthesis" EXACT []
synonym: "anterior pituitary gland formation" EXACT []
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0048855 ! adenohypophysis morphogenesis

[Term]
id: GO:0048848
name: neurohypophysis morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the neurohypophysis are generated and organized. The neurohypophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation." [GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "neurophysis morphogenesis" EXACT []
synonym: "posterior pituitary gland morphogenesis" EXACT []
synonym: "posterior pituitary morphogenesis" EXACT []
is_a: GO:0022612 ! gland morphogenesis
relationship: part_of GO:0021985 ! neurohypophysis development
relationship: part_of GO:0048850 ! hypophysis morphogenesis

[Term]
id: GO:0048849
name: neurohypophysis formation
namespace: biological_process
def: "The process that gives rise to neurohypophysis. This process pertains to the initial formation of a structure from unspecified parts. The neurohypophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation." [GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "neurophysis biosynthesis" EXACT []
synonym: "neurophysis formation" EXACT []
synonym: "posterior pituitary biosynthesis" EXACT []
synonym: "posterior pituitary formation" EXACT []
synonym: "posterior pituitary gland biosynthesis" EXACT []
synonym: "posterior pituitary gland formation" EXACT []
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0048848 ! neurohypophysis morphogenesis

[Term]
id: GO:0048850
name: hypophysis morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the hypophysis are generated and organized. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands." [GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "pituitary gland morphogenesis" EXACT []
is_a: GO:0022612 ! gland morphogenesis
relationship: part_of GO:0021983 ! pituitary gland development
relationship: part_of GO:0048852 ! diencephalon morphogenesis

[Term]
id: GO:0048851
name: hypophysis formation
namespace: biological_process
def: "The process in which the anatomical structures of the hypophysis are generated and organized. The hypophysis is an endocrine gland that secretes hormones that regulate many other glands." [GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "hypophysis biosynthesis" EXACT []
synonym: "pituitary gland biosynthesis" EXACT []
synonym: "pituitary gland formation" EXACT []
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0048850 ! hypophysis morphogenesis

[Term]
id: GO:0048852
name: diencephalon morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the diencephalon are generated and organized. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex." [GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0021536 ! diencephalon development
relationship: part_of GO:0048853 ! forebrain morphogenesis

[Term]
id: GO:0048853
name: forebrain morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the forebrain are generated and organized. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)." [GOC:cvs, GOC:dgh, GOC:dph, GOC:jid]
synonym: "prosencephalon morphogenesis" EXACT []
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0030900 ! forebrain development
relationship: part_of GO:0048854 ! brain morphogenesis

[Term]
id: GO:0048854
name: brain morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dgh, GOC:jid]
is_a: GO:0009887 ! organ morphogenesis
relationship: part_of GO:0007420 ! brain development

[Term]
id: GO:0048855
name: adenohypophysis morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the adenohypophysis are generated and organized. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus." [GOC:cvs, GOC:dgh, GOC:dph, GOC:jid]
synonym: "adenophysis morphogenesis" EXACT []
synonym: "anterior pituitary gland morphogenesis" EXACT []
synonym: "anterior pituitary morphogenesis" EXACT []
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0021984 ! adenohypophysis development
relationship: part_of GO:0048850 ! hypophysis morphogenesis

[Term]
id: GO:0048856
name: anatomical structure development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
subset: goslim_chembl
subset: goslim_generic
synonym: "development of an anatomical structure" EXACT []
is_a: GO:0032502 ! developmental process

[Term]
id: GO:0048857
name: neural nucleus development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a neural nucleus from its initial condition to its mature state. A neural nucleus is an anatomical structure consisting of a discrete aggregate of neuronal soma." [GO_REF:0000021, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development

[Term]
id: GO:0048858
name: cell projection morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a cell projection are generated and organized." [GO_REF:0000021, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0030030 ! cell projection organization
is_a: GO:0032990 ! cell part morphogenesis
relationship: part_of GO:0000902 ! cell morphogenesis

[Term]
id: GO:0048859
name: formation of anatomical boundary
namespace: biological_process
def: "The process in which the limits of an anatomical structure are generated. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis

[Term]
id: GO:0048860
name: glioblast division
namespace: biological_process
def: "The process resulting in the physical partitioning and separation of a glioblast into daughter cells." [GOC:devbiol]
is_a: GO:0051301 ! cell division

[Term]
id: GO:0048861
name: leukemia inhibitory factor signaling pathway
namespace: biological_process
def: "Any series of molecular signals initiated by the binding of leukemia inhibitory factor to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:devbiol, GOC:signaling]
synonym: "leukemia inhibitory factor signalling pathway" EXACT []
is_a: GO:0007167 ! enzyme linked receptor protein signaling pathway

[Term]
id: GO:0048863
name: stem cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [CL:0000034, GOC:isa_complete]
xref: Wikipedia:Stem_cell_differentiation
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0048864
name: stem cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of the stem cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to its specific fate." [CL:0000034, GOC:isa_complete]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0048863 ! stem cell differentiation

[Term]
id: GO:0048865
name: stem cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a stem cell." [CL:0000034, GOC:isa_complete]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0048863 ! stem cell differentiation

[Term]
id: GO:0048866
name: stem cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a stem cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [CL:0000034, GOC:isa_complete]
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0048865 ! stem cell fate commitment

[Term]
id: GO:0048867
name: stem cell fate determination
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a stem cell regardless of its environment; upon determination, the cell fate cannot be reversed." [CL:0000034, GOC:isa_complete]
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0048865 ! stem cell fate commitment

[Term]
id: GO:0048868
name: pollen tube development
namespace: biological_process
def: "The process whose specific outcome is the progression of a pollen tube over time, from its initial formation to a mature structure." [GOC:isa_complete]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0009856 ! pollination

[Term]
id: GO:0048869
name: cellular developmental process
namespace: biological_process
def: "A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition." [GOC:isa_complete]
subset: gosubset_prok
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0044767 ! single-organism developmental process

[Term]
id: GO:0048870
name: cell motility
namespace: biological_process
def: "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another." [GOC:dgh, GOC:dph, GOC:isa_complete, GOC:mlg]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: gosubset_prok
synonym: "cell locomotion" EXACT []
synonym: "cell movement" RELATED []
synonym: "movement of a cell" EXACT []
is_a: GO:0006928 ! movement of cell or subcellular component
is_a: GO:0040011 ! locomotion
relationship: part_of GO:0051674 ! localization of cell

[Term]
id: GO:0048871
name: multicellular organismal homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state at the level of the multicellular organism." [GOC:isa_complete]
is_a: GO:0042592 ! homeostatic process
is_a: GO:0044707 ! single-multicellular organism process

[Term]
id: GO:0048872
name: homeostasis of number of cells
namespace: biological_process
def: "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells." [GOC:isa_complete]
synonym: "cell population homeostasis" EXACT []
synonym: "homeostasis of cell number" EXACT [GOC:dph]
is_a: GO:0042592 ! homeostatic process

[Term]
id: GO:0048873
name: homeostasis of number of cells within a tissue
namespace: biological_process
def: "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in a tissue." [GOC:isa_complete]
is_a: GO:0001894 ! tissue homeostasis
is_a: GO:0048872 ! homeostasis of number of cells

[Term]
id: GO:0048874
name: homeostasis of number of cells in a free-living population
namespace: biological_process
def: "The biological process involved in maintaining the steady-state number of cells within a population of free-living cells such as the bacteria in the gut." [GOC:isa_complete]
subset: gosubset_prok
is_a: GO:0044764 ! multi-organism cellular process
is_a: GO:0048872 ! homeostasis of number of cells

[Term]
id: GO:0048875
name: chemical homeostasis within a tissue
namespace: biological_process
def: "Any process involved in the maintenance of the internal steady state of the amount of a chemical at the level of the tissue." [GOC:isa_complete]
is_a: GO:0001894 ! tissue homeostasis
is_a: GO:0048878 ! chemical homeostasis

[Term]
id: GO:0048876
name: chemical homeostasis within retina
namespace: biological_process
def: "Any process involved in the maintenance of the internal steady state of the amount of a chemical at the level of the retina." [GOC:isa_complete]
is_a: GO:0001895 ! retina homeostasis
is_a: GO:0048875 ! chemical homeostasis within a tissue

[Term]
id: GO:0048877
name: homeostasis of number of retina cells
namespace: biological_process
def: "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in the retina." [GOC:dph, GOC:isa_complete, GOC:tb]
is_a: GO:0001895 ! retina homeostasis
is_a: GO:0048873 ! homeostasis of number of cells within a tissue

[Term]
id: GO:0048878
name: chemical homeostasis
namespace: biological_process
def: "Any biological process involved in the maintenance of an internal steady state of a chemical." [GOC:isa_complete]
subset: gosubset_prok
is_a: GO:0042592 ! homeostatic process

[Term]
id: GO:0048880
name: sensory system development
namespace: biological_process
def: "The process whose specific outcome is the progression of a sensory system over time from its formation to the mature structure." [GOC:dgh]
is_a: GO:0048731 ! system development

[Term]
id: GO:0048881
name: mechanosensory lateral line system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the mechanosensory lateral line system over time, from its formation to the mature structure. The mechanosensory lateral line system consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head and body of all fishes and most amphibians. The neuromasts are innervated by several lateral line nerves, which project primarily to the hindbrain. The mechanosensory lateral line system is stimulated by local water displacements and vibrations, and detects propulsion of the fish through the water, as well as facilitating shoaling, prey capture, and predator and obstacle avoidance." [ISBN:0125296509]
synonym: "LL system development" EXACT [ISBN:0125296509]
is_a: GO:0048925 ! lateral line system development

[Term]
id: GO:0048882
name: lateral line development
namespace: biological_process
def: "The process whose specific outcome is the progression of the lateral line over time, from its formation to the mature structure. The lateral line consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head and body of all fishes and most amphibians. The lateral line develops from cranial ectodermal placodes situated behind the ear and between the eye and ear." [ISBN:0125296509]
synonym: "LL development" EXACT []
is_a: GO:0009888 ! tissue development
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0048925 ! lateral line system development

[Term]
id: GO:0048883
name: neuromast primordium migration
namespace: biological_process
def: "The migration of a cluster of a relatively undifferentiated cell originating at specific cephalic placodes and depositing proneuromasts along a developing lateral line, from which the neuromasts will develop." [PMID:15018940, PMID:15832385]
synonym: "lateral line primordium migration" EXACT []
is_a: GO:0016477 ! cell migration
relationship: part_of GO:0048882 ! lateral line development

[Term]
id: GO:0048884
name: neuromast development
namespace: biological_process
def: "The process whose specific outcome is the progression of the neuromast over time, from its formation to the mature structure. The neuromast is the sensory organ of the lateral line and is composed of a population of sensory hair cells, and nonsensory supporting cells and mantle cells. Neuromasts are located superficially on the epithelium or in lateral line canals." [ISBN:0125296509]
is_a: GO:0007423 ! sensory organ development
relationship: part_of GO:0048882 ! lateral line development

[Term]
id: GO:0048885
name: neuromast deposition
namespace: biological_process
def: "The process in which a migrating neuromast primordium deposits clusters of undifferentiated cells (proneuromasts) along its migratory path in a developing lateral line." [PMID:15018940]
is_a: GO:0030336 ! negative regulation of cell migration
relationship: part_of GO:0048884 ! neuromast development

[Term]
id: GO:0048886
name: neuromast hair cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neuromast hair cell. Hair cells are the sensory receptors of the neuromast and are located in a portion of the neuromast called the sensory strip. Each hair cell of the neuromast is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. There are approximately seven hair cells within each neuromast, with each hair cell innervated by afferent and efferent neurons." [CL:0000856, ISBN:0125296509]
is_a: GO:0035315 ! hair cell differentiation
is_a: GO:0042490 ! mechanoreceptor differentiation
is_a: GO:0048934 ! peripheral nervous system neuron differentiation
relationship: part_of GO:0048884 ! neuromast development

[Term]
id: GO:0048887
name: cupula development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cupula over time, from its formation to the mature structure. The cupula is secreted by mantle cells and the ciliary bundles of all of the hair cells of the neuromast are embedded in it. The cupula provides a mechanical linkage between the hair cells and the external hydrodynamic environment. The cupula of superficial neuromasts grows continuously, while the height of the cupula of canal neuromasts is limited by canal diameter." [ISBN:0125296509]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048884 ! neuromast development

[Term]
id: GO:0048888
name: neuromast mantle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neuromast mantle cell. Mantle cells are non-sensory cells that surround the sensory strip, separating the neuromast from the epidermis. Mantle cells secrete the cupula in which the ciliary bundles of all of the hair cells are embedded." [ISBN:0125296509]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0048884 ! neuromast development

[Term]
id: GO:0048889
name: neuromast support cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neuromast support cell. Support cells are non-sensory cells of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; they are surrounded by mantle cells." [ISBN:0125296509]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0048884 ! neuromast development

[Term]
id: GO:0048890
name: lateral line ganglion development
namespace: biological_process
def: "The process whose specific outcome is the progression of the lateral line ganglion over time, from its formation to the mature structure. The lateral line ganglion develops from cranial ectodermal placodes situated between the eye and ear and behind the ear." [ISBN:0125296509, ISBN:0387968377]
synonym: "gLL ganglion development" EXACT []
is_a: GO:0061550 ! cranial ganglion development
relationship: part_of GO:0007422 ! peripheral nervous system development
relationship: part_of GO:0048925 ! lateral line system development

[Term]
id: GO:0048891
name: lateral line ganglion neuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a lateral line ganglion neuron." [PMID:15018940]
synonym: "gLL neuron differentiation" EXACT []
is_a: GO:0048934 ! peripheral nervous system neuron differentiation
relationship: part_of GO:0048890 ! lateral line ganglion development

[Term]
id: GO:0048892
name: lateral line nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of the lateral line nerve over time, form its formation to the mature structure. Lateral line nerves project primarily to an octavolateralis column in the hindbrain that consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus." [ISBN:0125296509]
synonym: "nLL development" EXACT []
is_a: GO:0021545 ! cranial nerve development
relationship: part_of GO:0048925 ! lateral line system development

[Term]
id: GO:0048893
name: afferent axon development in lateral line nerve
namespace: biological_process
def: "The process whose specific outcome is the progression of an afferent axon in a lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the afferent axons in any lateral line nerve." [PMID:15832385]
is_a: GO:0061564 ! axon development
relationship: part_of GO:0048892 ! lateral line nerve development

[Term]
id: GO:0048894
name: efferent axon development in a lateral line nerve
namespace: biological_process
def: "The process whose specific outcome is the progression of an efferent axon in a lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the efferent axons in any lateral line nerve." [PMID:15832385]
is_a: GO:0021955 ! central nervous system neuron axonogenesis
relationship: part_of GO:0048892 ! lateral line nerve development

[Term]
id: GO:0048895
name: lateral line nerve glial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a glial cell in a lateral line nerve." [PMID:12062041]
is_a: GO:0010001 ! glial cell differentiation
relationship: part_of GO:0048892 ! lateral line nerve development

[Term]
id: GO:0048896
name: lateral line nerve glial cell migration
namespace: biological_process
def: "The movement of a glial cell along the axons in a lateral line nerve." [PMID:12062041]
synonym: "glial cell migration in lateral line nerve" EXACT [GOC:curators]
is_a: GO:0008347 ! glial cell migration
relationship: part_of GO:0048892 ! lateral line nerve development

[Term]
id: GO:0048897
name: myelination of lateral line nerve axons
namespace: biological_process
def: "The formation of compact myelin sheaths around the axons of a lateral line nerve." [PMID:12112375]
is_a: GO:0042552 ! myelination
relationship: part_of GO:0048938 ! lateral line nerve glial cell morphogenesis involved in differentiation

[Term]
id: GO:0048898
name: anterior lateral line system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the anterior lateral line system over time, from its formation to the mature structure. The anterior lateral line system develops from cranial ectodermal placodes, situated between the eye and the ear, that give rise to both the neuromasts and the anterior lateral line sensory nerves that innervate the neuromasts. The anterior lateral line system consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head of all fishes and most amphibians and are innervated by several lateral line nerves, which project to the hindbrain. The anterior lateral line system is stimulated by local water displacements and vibrations, and detects propulsion of the fish through the water, as well as facilitating shoaling, prey capture, and predator and obstacle avoidance." [ISBN:0125296509, PMID:15018940]
synonym: "ALL system development" RELATED []
is_a: GO:0048925 ! lateral line system development
relationship: part_of GO:0048881 ! mechanosensory lateral line system development

[Term]
id: GO:0048899
name: anterior lateral line development
namespace: biological_process
def: "The process whose specific outcome is the progression of the anterior lateral line over time, from its formation to the mature structure. The anterior lateral line consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head of all fishes and most amphibians. The anterior lateral line develops from cranial ectodermal placodes situated between the eye and ear." [ISBN:0125296509]
synonym: "anterior LL development" EXACT []
is_a: GO:0048882 ! lateral line development
relationship: part_of GO:0048898 ! anterior lateral line system development

[Term]
id: GO:0048900
name: anterior lateral line neuromast primordium migration
namespace: biological_process
def: "The migration of a cluster of a relatively undifferentiated cell along the developing anterior lateral line, originating from cranial ectodermal placodes situated between the eye and the ear. The neuromast primordium deposits proneuromasts along the lateral line, from which the neuromasts will develop." [GOC:dgh, PMID:15832385]
synonym: "ALL neuromast primordium migration" EXACT []
is_a: GO:0048883 ! neuromast primordium migration
relationship: part_of GO:0048899 ! anterior lateral line development

[Term]
id: GO:0048901
name: anterior lateral line neuromast development
namespace: biological_process
def: "The process whose specific outcome is the progression of the anterior lateral line neuromast over time, from its formation to the mature structure. The neuromast is the sensory receptor of the anterior lateral line system and is composed of a population of sensory hair cells, and nonsensory supporting cells and mantle cells. Neuromast are located superficially on the epithelium or in lateral line canals." [ISBN:0125296509]
is_a: GO:0048884 ! neuromast development
relationship: part_of GO:0048899 ! anterior lateral line development

[Term]
id: GO:0048902
name: anterior lateral line neuromast deposition
namespace: biological_process
def: "The process in which a migrating neuromast primordium deposits clusters of undifferentiated cells (proneuromasts) along its migratory path in the developing anterior lateral line." [PMID:15832385]
is_a: GO:0048885 ! neuromast deposition
relationship: part_of GO:0048901 ! anterior lateral line neuromast development

[Term]
id: GO:0048903
name: anterior lateral line neuromast hair cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an anterior lateral line neuromast hair cell. Neuromast hair cells are the sensory receptors of the neuromast and are located in a portion of the neuromast called the sensory strip. Each hair cell of the neuromast is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. There are approximately seven hair cells within each neuromast, with each hair cell innervated by afferent and efferent neurons." [ISBN:0125296509, ISBN:0387968377]
is_a: GO:0048886 ! neuromast hair cell differentiation
relationship: part_of GO:0048901 ! anterior lateral line neuromast development

[Term]
id: GO:0048904
name: anterior lateral line neuromast cupula development
namespace: biological_process
def: "The process whose specific outcome is the progression of the anterior lateral line neuromast cupula over time, from its formation to the mature structure. The cupula is secreted by mantle cells and the ciliary bundles of all of the hair cells of the neuromast are embedded in it. The cupula provides a mechanical linkage between the hair cells and the external hydrodynamic environment. The cupula of superficial neuromasts grows continuously, while the height of the cupula of canal neuromasts is limited by canal diameter." [ISBN:0125296509]
is_a: GO:0048887 ! cupula development
relationship: part_of GO:0048901 ! anterior lateral line neuromast development

[Term]
id: GO:0048905
name: anterior lateral line neuromast mantle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an anterior lateral line neuromast mantle cell. Mantle cells are non-sensory cells that surround the sensory strip, separating the neuromast from the epidermis. Mantle cells secrete the cupula in which the ciliary bundles of all of the hair cells are embedded." [ISBN:0125296509]
is_a: GO:0048888 ! neuromast mantle cell differentiation
relationship: part_of GO:0048901 ! anterior lateral line neuromast development

[Term]
id: GO:0048906
name: anterior lateral line neuromast support cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an anterior lateral line neuromast support cell. Support cells are non-sensory cells of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; they are surrounded by mantle cells." [ISBN:0387968377]
is_a: GO:0048889 ! neuromast support cell differentiation
relationship: part_of GO:0048901 ! anterior lateral line neuromast development

[Term]
id: GO:0048907
name: anterior lateral line ganglion development
namespace: biological_process
def: "The process whose specific outcome is the progression of the anterior lateral line ganglion over time, from its formation to the mature structure. The anterior lateral line ganglion develops from cranial ectodermal placodes situated between the eye and ear." [ISBN:0125296509]
synonym: "gALL development" EXACT []
is_a: GO:0048890 ! lateral line ganglion development
relationship: part_of GO:0048898 ! anterior lateral line system development

[Term]
id: GO:0048908
name: anterior lateral line ganglion neuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron of the anterior lateral line ganglion." [PMID:15018940]
is_a: GO:0048891 ! lateral line ganglion neuron differentiation
relationship: part_of GO:0048907 ! anterior lateral line ganglion development

[Term]
id: GO:0048909
name: anterior lateral line nerve development
namespace: biological_process
alt_id: GO:0021734
def: "The process whose specific outcome is the progression of the anterior lateral line nerve over time, form its formation to the mature structure. The anterior lateral line nerve contains efferent axons that innervate hair cells of the ALL and afferent axons that project to an octavolateralis column in the hindbrain. The octavolateralis column consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0125296509]
comment: This term was added by GO_REF:0000021.
synonym: "ALLN development" EXACT []
synonym: "nALL development" EXACT []
synonym: "rostral lateral line nerve development" EXACT []
is_a: GO:0048892 ! lateral line nerve development
relationship: part_of GO:0048898 ! anterior lateral line system development

[Term]
id: GO:0048910
name: afferent axon development in anterior lateral line nerve
namespace: biological_process
def: "The process whose specific outcome is the progression of an afferent axon in the anterior lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the afferent axons in the anterior lateral line nerve." [PMID:15018940]
is_a: GO:0048893 ! afferent axon development in lateral line nerve
relationship: part_of GO:0048909 ! anterior lateral line nerve development

[Term]
id: GO:0048911
name: efferent axon development in anterior lateral line nerve
namespace: biological_process
def: "The process whose specific outcome is the progression of an efferent axon in the anterior lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the efferent axons in the anterior lateral line nerve." [PMID:15018940]
is_a: GO:0048894 ! efferent axon development in a lateral line nerve
relationship: part_of GO:0048909 ! anterior lateral line nerve development

[Term]
id: GO:0048912
name: glial cell migration in anterior lateral line nerve
namespace: biological_process
def: "The movement of a glial cell along the axons in the anterior lateral line nerve." [PMID:12062041]
is_a: GO:0048896 ! lateral line nerve glial cell migration
relationship: part_of GO:0048909 ! anterior lateral line nerve development

[Term]
id: GO:0048913
name: anterior lateral line nerve glial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a glial cell in the anterior lateral line nerve." [PMID:15832385]
is_a: GO:0048895 ! lateral line nerve glial cell differentiation
relationship: part_of GO:0048909 ! anterior lateral line nerve development

[Term]
id: GO:0048914
name: myelination of anterior lateral line nerve axons
namespace: biological_process
def: "The formation of compact myelin sheaths around the axons of the anterior lateral line nerve." [PMID:12112375]
is_a: GO:0048897 ! myelination of lateral line nerve axons
relationship: part_of GO:0048940 ! anterior lateral line nerve glial cell morphogenesis involved in differentiation

[Term]
id: GO:0048915
name: posterior lateral line system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the posterior lateral line system over time, from its formation to the mature structure. The posterior lateral line system develops from cranial ectodermal placodes, situated behind the ear, that give rise to both the neuromasts and the posterior lateral line sensory nerves that innervate the neuromasts. The posterior lateral line system consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head of all fishes and most amphibians. The neuromasts are innervated by several lateral line nerves, which project primarily to the hindbrain. The posterior mechanosensory lateral line system is stimulated by local water displacements and vibrations, and detects propulsion of the fish through the water, as well as facilitating shoaling, prey capture, and predator and obstacle avoidance." [ISBN:0125296509, PMID:15018940]
synonym: "PLL" RELATED []
is_a: GO:0048925 ! lateral line system development
relationship: part_of GO:0048881 ! mechanosensory lateral line system development

[Term]
id: GO:0048916
name: posterior lateral line development
namespace: biological_process
def: "The process whose specific outcome is the progression of the posterior lateral line over time, from its formation to the mature structure. The posterior lateral line consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the body and trunk of all fishes and most amphibians. The posterior lateral line develops from cranial ectodermal placodes situated behind the ear." [ISBN:0125296509]
synonym: "PLL development" EXACT []
is_a: GO:0048882 ! lateral line development
relationship: part_of GO:0048915 ! posterior lateral line system development

[Term]
id: GO:0048917
name: posterior lateral line ganglion development
namespace: biological_process
def: "The process whose specific outcome is the progression of the posterior lateral line ganglion over time, from its formation to the mature structure. The posterior lateral line ganglion develops from cranial ectodermal placodes situated behind the ear." [ISBN:0125296509, ISBN:0387968377]
synonym: "gPLL development" EXACT []
is_a: GO:0048890 ! lateral line ganglion development
relationship: part_of GO:0048915 ! posterior lateral line system development

[Term]
id: GO:0048918
name: posterior lateral line nerve development
namespace: biological_process
alt_id: GO:0021733
def: "The process whose specific outcome is the progression of the posterior lateral line nerve over time, from its formation to the mature structure. The posterior lateral line nerve innervates hair cells of the PLL and projects to an octavolateralis column in the hindbrain that consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0125296509]
comment: This term was added by GO_REF:0000021.
synonym: "caudal lateral line nerve development" EXACT []
synonym: "PLLN development" EXACT []
is_a: GO:0048892 ! lateral line nerve development
relationship: part_of GO:0048915 ! posterior lateral line system development

[Term]
id: GO:0048919
name: posterior lateral line neuromast development
namespace: biological_process
def: "The process whose specific outcome is the progression of the posterior lateral line neuromast over time, from its formation to the mature structure. The neuromast is the sensory receptor of the anterior lateral line system and is composed of a population of sensory hair cells, and nonsensory supporting cells and mantle cells. Neuromast are located superficially on the epithelium or in lateral line canals." [ISBN:0125296509]
is_a: GO:0048884 ! neuromast development
relationship: part_of GO:0048916 ! posterior lateral line development

[Term]
id: GO:0048920
name: posterior lateral line neuromast primordium migration
namespace: biological_process
def: "The migration of a relatively undifferentiated cell along the developing posterior lateral line, originating from cranial ectodermal placodes situated behind the ear. The neuromast primordium deposits proneuromasts along the lateral line, from which the neuromasts will develop." [GOC:dgh, PMID:15832385]
synonym: "PLL neuromast primordium migration" EXACT []
is_a: GO:0048883 ! neuromast primordium migration
relationship: part_of GO:0048916 ! posterior lateral line development

[Term]
id: GO:0048921
name: posterior lateral line neuromast cupula development
namespace: biological_process
def: "The process whose specific outcome is the progression of the posterior lateral line neuromast cupula over time, from its formation to the mature structure. The cupula is secreted by mantle cells and the ciliary bundles of all of the hair cells of the neuromast are embedded in it. The cupula provides a mechanical linkage between the hair cells and the external hydrodynamic environment. The cupula of superficial neuromasts grows continuously, while the height of the cupula of canal neuromasts is limited by canal diameter." [ISBN:0125296509]
is_a: GO:0048887 ! cupula development
relationship: part_of GO:0048919 ! posterior lateral line neuromast development

[Term]
id: GO:0048922
name: posterior lateral line neuromast deposition
namespace: biological_process
def: "The process in which a migrating neuromast primordium deposits clusters of undifferentiated cells (proneuromasts) along its migratory path in the developing posterior lateral line." [PMID:15832385]
is_a: GO:0048885 ! neuromast deposition
relationship: part_of GO:0048919 ! posterior lateral line neuromast development

[Term]
id: GO:0048923
name: posterior lateral line neuromast hair cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a posterior lateral line neuromast hair cell. (N.B. This may be development of neuromast hair cell type or a set of cell of neuromast hair cell type. This will involve the change of a cell or set of cells from one cell identity to another). Hair cells are the sensory receptors of the neuromast and are located in a portion of the neuromast called the sensory strip. Each hair cell of the neuromast is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. There are approximately seven hair cells within each neuromast, with each hair cell innervated by afferent and efferent neurons." [ISBN:0125296509]
is_a: GO:0048886 ! neuromast hair cell differentiation
relationship: part_of GO:0048919 ! posterior lateral line neuromast development

[Term]
id: GO:0048924
name: posterior lateral line neuromast mantle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a posterior lateral line neuromast mantle cell. (N.B. This may be development of neuromast mantle cell type or a set of cells of neuromast mantle cell type. This will involve the change of a cell or set of cells from one cell identity to another). Mantle cells are non-sensory cells that surround the sensory strip, separating the neuromast from the epidermis. Mantle cells secrete the cupula in which the ciliary bundles of all of the hair cells are embedded." [ISBN:0125296509]
is_a: GO:0048888 ! neuromast mantle cell differentiation
relationship: part_of GO:0048919 ! posterior lateral line neuromast development

[Term]
id: GO:0048925
name: lateral line system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the lateral line system over time, from its formation to the mature structure. The lateral line system is a network of sensory organs (neuromasts) and lateral line nerves located superficially on the skin or just under the skin in fluid-filled canals on the head and body of all fishes and most amphibians. The lateral line system develops from cranial ectodermal placodes situated between the eye and ear." [GOC:dgh, ISBN:0125296509]
is_a: GO:0048880 ! sensory system development

[Term]
id: GO:0048926
name: electrosensory lateral line system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the electrosensory lateral line system over time, from its formation to the mature structure." [GOC:dgh]
is_a: GO:0048925 ! lateral line system development

[Term]
id: GO:0048927
name: posterior lateral line neuromast support cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a posterior lateral line neuromast support cell. Support cells are non-sensory cells of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; they are surrounded by mantle cells." [ISBN:0387968377]
is_a: GO:0048889 ! neuromast support cell differentiation
relationship: part_of GO:0048919 ! posterior lateral line neuromast development

[Term]
id: GO:0048928
name: posterior lateral line ganglion neuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron of the posterior lateral line ganglion." [PMID:15018940]
is_a: GO:0048891 ! lateral line ganglion neuron differentiation
relationship: part_of GO:0048917 ! posterior lateral line ganglion development

[Term]
id: GO:0048929
name: efferent axon development in posterior lateral line nerve
namespace: biological_process
def: "The process whose specific outcome is the progression of an efferent axon in the posterior lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the efferent axons in the posterior lateral line nerve." [PMID:15018940]
is_a: GO:0048894 ! efferent axon development in a lateral line nerve
relationship: part_of GO:0048918 ! posterior lateral line nerve development

[Term]
id: GO:0048930
name: glial cell migration in posterior lateral line nerve
namespace: biological_process
def: "The movement of a glial cell along the axons in the posterior lateral line nerve." [PMID:12062041]
is_a: GO:0048896 ! lateral line nerve glial cell migration
relationship: part_of GO:0048918 ! posterior lateral line nerve development

[Term]
id: GO:0048931
name: posterior lateral line nerve glial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a glial cell in the posterior lateral line nerve." [PMID:15832385]
is_a: GO:0048895 ! lateral line nerve glial cell differentiation
relationship: part_of GO:0048918 ! posterior lateral line nerve development

[Term]
id: GO:0048932
name: myelination of posterior lateral line nerve axons
namespace: biological_process
def: "The formation of compact myelin sheaths around the axons of the posterior lateral line nerve." [PMID:12112375]
is_a: GO:0048897 ! myelination of lateral line nerve axons
relationship: part_of GO:0048942 ! posterior lateral line nerve glial cell morphogenesis involved in differentiation

[Term]
id: GO:0048933
name: afferent axon development in posterior lateral line nerve
namespace: biological_process
def: "The process whose specific outcome is the progression of an afferent axon in the posterior lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the afferent axons in the posterior lateral line nerve." [PMID:15018940]
is_a: GO:0048893 ! afferent axon development in lateral line nerve
relationship: part_of GO:0048918 ! posterior lateral line nerve development

[Term]
id: GO:0048934
name: peripheral nervous system neuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the peripheral nervous system." [GOC:dgh]
is_a: GO:0030182 ! neuron differentiation
relationship: part_of GO:0007422 ! peripheral nervous system development

[Term]
id: GO:0048935
name: peripheral nervous system neuron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron." [GOC:dgh]
is_a: GO:0048666 ! neuron development
relationship: part_of GO:0048934 ! peripheral nervous system neuron differentiation

[Term]
id: GO:0048936
name: peripheral nervous system neuron axonogenesis
namespace: biological_process
def: "Generation of a long process from a neuron whose cell body resides in the peripheral nervous system. The axon carries action potential from the cell body towards target cells." [GOC:dgh]
is_a: GO:0007409 ! axonogenesis
relationship: part_of GO:0048935 ! peripheral nervous system neuron development

[Term]
id: GO:0048937
name: lateral line nerve glial cell development
namespace: biological_process
def: "The process aimed at the progression of a lateral line glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dgh]
is_a: GO:0021782 ! glial cell development
relationship: part_of GO:0048895 ! lateral line nerve glial cell differentiation

[Term]
id: GO:0048938
name: lateral line nerve glial cell morphogenesis involved in differentiation
namespace: biological_process
def: "The process in which the structure of a glial cell in a lateral line nerve is generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a glial cell in a lateral line nerve." [GOC:dgh]
is_a: GO:0000904 ! cell morphogenesis involved in differentiation
intersection_of: GO:0000904 ! cell morphogenesis involved in differentiation
intersection_of: part_of GO:0048937 ! lateral line nerve glial cell development
relationship: part_of GO:0048937 ! lateral line nerve glial cell development

[Term]
id: GO:0048939
name: anterior lateral line nerve glial cell development
namespace: biological_process
def: "The process aimed at the progression of a glial cell in the anterior lateral line nerve over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dgh]
is_a: GO:0048937 ! lateral line nerve glial cell development
relationship: part_of GO:0048913 ! anterior lateral line nerve glial cell differentiation

[Term]
id: GO:0048940
name: anterior lateral line nerve glial cell morphogenesis involved in differentiation
namespace: biological_process
def: "The process in which the structures of a glial cell in the anterior lateral line nerve are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a glial cell in the anterior lateral line nerve." [GOC:dgh]
is_a: GO:0048938 ! lateral line nerve glial cell morphogenesis involved in differentiation
intersection_of: GO:0000904 ! cell morphogenesis involved in differentiation
intersection_of: part_of GO:0048939 ! anterior lateral line nerve glial cell development
relationship: part_of GO:0048939 ! anterior lateral line nerve glial cell development

[Term]
id: GO:0048941
name: posterior lateral line nerve glial cell development
namespace: biological_process
def: "The process aimed at the progression of a glial cell in the posterior lateral line nerve over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dgh]
is_a: GO:0048937 ! lateral line nerve glial cell development
relationship: part_of GO:0048931 ! posterior lateral line nerve glial cell differentiation

[Term]
id: GO:0048942
name: posterior lateral line nerve glial cell morphogenesis involved in differentiation
namespace: biological_process
def: "The process in which the structures of a glial cell in the posterior lateral line nerve are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a glial cell in the posterior lateral line nerve." [GOC:dgh]
is_a: GO:0048938 ! lateral line nerve glial cell morphogenesis involved in differentiation
intersection_of: GO:0000904 ! cell morphogenesis involved in differentiation
intersection_of: part_of GO:0048941 ! posterior lateral line nerve glial cell development
relationship: part_of GO:0048941 ! posterior lateral line nerve glial cell development

[Term]
id: GO:0050000
name: chromosome localization
namespace: biological_process
def: "Any process in which a chromosome is transported to, or maintained in, a specific location." [GOC:ai]
synonym: "chromosome localisation" EXACT [GOC:mah]
synonym: "establishment and maintenance of chromosome localization" EXACT []
synonym: "establishment and maintenance of chromosome position" EXACT []
is_a: GO:0051640 ! organelle localization

[Term]
id: GO:0050001
name: D-glutaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + L-glutamine = NH3 + D-glutamate." [EC:3.5.1.35, MetaCyc:D-GLUTAMINASE-RXN]
synonym: "D-glutamine amidohydrolase activity" EXACT [EC:3.5.1.35]
xref: EC:3.5.1.35
xref: MetaCyc:D-GLUTAMINASE-RXN
xref: RHEA:22843
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050002
name: D-proline reductase (dithiol) activity
namespace: molecular_function
def: "Catalysis of the reaction: lipoate + 5-aminopentanoate = dihydrolipoate + D-proline." [EC:1.21.4.1, MetaCyc:D-PROLINE-REDUCTASE-(DITHIOL)-RXN]
comment: Note that this function was formerly EC:1.4.4.1.
synonym: "5-aminopentanoate:lipoate oxidoreductase (cyclizing)" EXACT [EC:1.21.4.1]
xref: EC:1.21.4.1
xref: MetaCyc:1.21.4.1-RXN
xref: RHEA:12740
is_a: GO:0050485 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor

[Term]
id: GO:0050003
name: deoxycytidylate C-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dCMP = 2'-deoxy-5-methyl-5'-cytidylate + 7,8-dihydrofolate." [EC:2.1.1.54, RHEA:11571]
synonym: "5,10-methylenetetrahydrofolate:dCMP C-methyltransferase activity" EXACT [EC:2.1.1.54]
synonym: "dCMP methyltransferase activity" EXACT [EC:2.1.1.54]
synonym: "deoxycytidylate methyltransferase activity" EXACT [EC:2.1.1.54]
xref: EC:2.1.1.54
xref: KEGG:R01670
xref: MetaCyc:DEOXYCYTIDYLATE-C-METHYLTRANSFERASE-RXN
xref: RHEA:11571
is_a: GO:0008169 ! C-methyltransferase activity

[Term]
id: GO:0050004
name: isoflavone 7-O-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + isoflavone = UDP + isoflavone 7-O-beta-D-glucoside." [EC:2.4.1.170, MetaCyc:ISOFLAVONE-7-O-GLUCOSYLTRANSFERASE-RXN]
synonym: "UDP-glucose:isoflavone 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.170]
synonym: "UDPglucose-flavonoid 7-O-glucosyltransferase activity" EXACT [EC:2.4.1.170]
synonym: "UDPglucose:isoflavone 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.170]
synonym: "UDPglucose:isoflavone 7-O-glucosyltransferase activity" EXACT [EC:2.4.1.170]
synonym: "uridine diphosphoglucose-isoflavone 7-O-glucosyltransferase activity" EXACT [EC:2.4.1.170]
xref: EC:2.4.1.170
xref: MetaCyc:ISOFLAVONE-7-O-GLUCOSYLTRANSFERASE-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0050005
name: isohexenylglutaconyl-CoA hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H(2)O." [EC:4.2.1.57, RHEA:24147]
synonym: "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA hydro-lyase [3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA-forming]" RELATED [EC:4.2.1.57]
synonym: "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA hydro-lyase activity" EXACT [EC:4.2.1.57]
synonym: "3-hydroxy-3-isohexenylglutaryl-CoA-hydrolase activity" EXACT [EC:4.2.1.57]
synonym: "beta-isohexenylglutaconyl-CoA-hydratase activity" EXACT [EC:4.2.1.57]
synonym: "isohexenylglutaconyl coenzyme A hydratase activity" EXACT [EC:4.2.1.57]
xref: EC:4.2.1.57
xref: KEGG:R03493
xref: MetaCyc:ISOHEXENYLGLUTACONYL-COA-HYDRATASE-RXN
xref: RHEA:24147
xref: UM-BBD_reactionID:r1167
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050006
name: isomaltulose synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: sucrose = 6-O-alpha-D-glucopyranosyl-D-fructofuranose." [EC:5.4.99.11, MetaCyc:ISOMALTULOSE-SYNTHASE-RXN]
synonym: "isomaltulose synthetase activity" EXACT [EC:5.4.99.11]
synonym: "sucrose alpha-glucosyltransferase activity" EXACT [EC:5.4.99.11]
synonym: "sucrose glucosylmutase activity" EXACT [EC:5.4.99.11]
synonym: "trehalulose synthase activity" EXACT [EC:5.4.99.11]
xref: EC:5.4.99.11
xref: MetaCyc:ISOMALTULOSE-SYNTHASE-RXN
xref: RHEA:24035
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0050007
name: isonocardicin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nocardicin E = S-methyl-5'-thioadenosine + H(+) + isonocardicin A." [EC:2.5.1.38, RHEA:19848]
synonym: "nocardicin aminocarboxypropyltransferase activity" EXACT [EC:2.5.1.38]
synonym: "S-adenosyl-L-methionine:nocardicin-E 3-amino-3-carboxypropyltransferase activity" EXACT [EC:2.5.1.38]
xref: EC:2.5.1.38
xref: KEGG:R03072
xref: MetaCyc:ISONOCARDICIN-SYNTHASE-RXN
xref: RHEA:19848
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0050008
name: isopiperitenone delta-isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: isopiperitenone = piperitenone." [EC:5.3.3.11, RHEA:21519]
synonym: "isopiperitenone D-isomerase activity" EXACT []
synonym: "isopiperitenone delta8-delta4-isomerase activity" EXACT [EC:5.3.3.11]
xref: EC:5.3.3.11
xref: KEGG:R03782
xref: MetaCyc:ISOPIPERITENONE-DELTA-ISOMERASE-RXN
xref: RHEA:21519
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0050009
name: isopropanol dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP(+) + propan-2-ol = acetone + H(+) + NADPH." [EC:1.1.1.80, RHEA:21795]
synonym: "propan-2-ol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.80]
xref: EC:1.1.1.80
xref: KEGG:R01550
xref: MetaCyc:ISOPROPANOL-DEHYDROGENASE-NADP+-RXN
xref: RHEA:21795
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050010
name: isovitexin beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: isovitexin + UDP-D-glucose = H(+) + isovitexin 2''-O-beta-D-glucoside + UDP." [EC:2.4.1.106, RHEA:19532]
synonym: "isovitexin b-glucosyltransferase activity" EXACT []
synonym: "UDP-glucose:isovitexin 2''-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.106]
synonym: "UDPglucose:isovitexin 2''-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.106]
synonym: "uridine diphosphoglucose-isovitexin 2''-glucosyltransferase activity" EXACT [EC:2.4.1.106]
xref: EC:2.4.1.106
xref: KEGG:R03686
xref: MetaCyc:ISOVITEXIN-BETA-GLUCOSYLTRANSFERASE-RXN
xref: RHEA:19532
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0050011
name: itaconyl-CoA hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: citramalyl-CoA = itaconyl-CoA + H2O." [EC:4.2.1.56, MetaCyc:ITACONYL-COA-HYDRATASE-RXN]
synonym: "citramalyl-CoA hydro-lyase (itaconyl-CoA-forming)" EXACT [EC:4.2.1.56]
synonym: "citramalyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.56]
synonym: "itaconyl coenzyme A hydratase activity" EXACT [EC:4.2.1.56]
xref: EC:4.2.1.56
xref: MetaCyc:ITACONYL-COA-HYDRATASE-RXN
xref: RHEA:13788
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050012
name: juglone 3-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-hydroxy-1,4-naphthoquinone + AH(2) + O(2) = 3,5-dihydroxy-1,4-naphthoquinone + A + H(2)O + H(+)." [EC:1.14.99.27, RHEA:18748]
synonym: "5-hydroxy-1,4-naphthoquinone,hydrogen-donor:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.99.27]
synonym: "juglone hydroxylase activity" EXACT []
synonym: "naphthoquinone hydroxylase activity" EXACT [EC:1.14.99.27]
synonym: "naphthoquinone-hydroxylase activity" EXACT [EC:1.14.99.27]
xref: EC:1.14.99.27
xref: KEGG:R04327
xref: MetaCyc:JUGLONE-3-MONOOXYGENASE-RXN
xref: RHEA:18748
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0050013
name: 2-dehydropantoate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-dehydropantoate = 3-methyl-2-oxobutanoate + formaldehyde." [EC:4.1.2.12, MetaCyc:KETOPANTOALDOLASE-RXN]
synonym: "2-dehydropantoate formaldehyde-lyase (3-methyl-2-oxobutanoate-forming)" EXACT [EC:4.1.2.12]
synonym: "2-dehydropantoate formaldehyde-lyase activity" EXACT [EC:4.1.2.12]
synonym: "ketopantoaldolase activity" EXACT []
xref: EC:4.1.2.12
xref: MetaCyc:KETOPANTOALDOLASE-RXN
xref: RHEA:23279
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0050014
name: ketotetrose-phosphate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-erythrulose 1-phosphate = formaldehyde + glycerone phosphate." [EC:4.1.2.2, RHEA:20935]
synonym: "erythrose-1-phosphate synthase activity" EXACT [EC:4.1.2.2]
synonym: "erythrulose-1-phosphate formaldehyde-lyase (glycerone-phosphate-forming)" EXACT [EC:4.1.2.2]
synonym: "erythrulose-1-phosphate formaldehyde-lyase activity" EXACT [EC:4.1.2.2]
synonym: "erythrulose-1-phosphate synthetase activity" EXACT [EC:4.1.2.2]
synonym: "phosphoketotetrose aldolase activity" EXACT [EC:4.1.2.2]
xref: EC:4.1.2.2
xref: KEGG:R01014
xref: MetaCyc:KETOTETROSE-PHOSPHATE-ALDOLASE-RXN
xref: RHEA:20935
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0050015
name: kievitone hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: kievitone hydrate = H(2)O + H(+) + kievitone." [EC:4.2.1.95, RHEA:23607]
synonym: "KHase activity" EXACT [EC:4.2.1.95]
synonym: "kievitone-hydrate hydro-lyase (kievitone-forming)" EXACT [EC:4.2.1.95]
synonym: "kievitone-hydrate hydro-lyase activity" EXACT [EC:4.2.1.95]
xref: EC:4.2.1.95
xref: KEGG:R03622
xref: MetaCyc:KIEVITONE-HYDRATASE-RXN
xref: RHEA:23607
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050016
name: kynurenine 7,8-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: kynurenate + donor-H2 + O2 = 7,8-dihydro-7,8-dihydroxykynurenate + acceptor." [EC:1.14.99.2, MetaCyc:KYNURENINE-78-HYDROXYLASE-RXN]
synonym: "kynurenate 7,8-hydroxylase activity" EXACT [EC:1.14.99.2]
synonym: "kynurenate,hydrogen-donor:oxygen oxidoreductase (hydroxylating)" EXACT [EC:1.14.99.2]
synonym: "kynurenic acid hydroxylase activity" EXACT [EC:1.14.99.2]
synonym: "kynurenic hydroxylase activity" EXACT [EC:1.14.99.2]
xref: EC:1.14.99.2
xref: MetaCyc:KYNURENINE-78-HYDROXYLASE-RXN
xref: RHEA:11971
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0050017
name: L-3-cyanoalanine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-cysteine + HCN = sulfide + L-3-cyanoalanine." [EC:4.4.1.9, MetaCyc:L-3-CYANOALANINE-SYNTHASE-RXN]
synonym: "beta-cyano-L-alanine synthase activity" EXACT [EC:4.4.1.9]
synonym: "beta-cyanoalanine synthase activity" EXACT [EC:4.4.1.9]
synonym: "beta-cyanoalanine synthetase activity" EXACT [EC:4.4.1.9]
synonym: "L-cysteine hydrogen-sulfide-lyase (adding HCN)" EXACT [EC:4.4.1.9]
synonym: "L-cysteine hydrogen-sulfide-lyase (adding hydrogen cyanide; L-3-cyanoalanine-forming)" EXACT [EC:4.4.1.9]
xref: EC:4.4.1.9
xref: MetaCyc:L-3-CYANOALANINE-SYNTHASE-RXN
xref: RHEA:17824
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0050018
name: L-amino-acid dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: an L-amino acid + H2O + NAD+ = a 2-oxo acid + NH3 + NADH." [EC:1.4.1.5, MetaCyc:L-AMINO-ACID-DEHYDROGENASE-RXN]
synonym: "L-amino-acid:NAD+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.5]
xref: EC:1.4.1.5
xref: MetaCyc:L-AMINO-ACID-DEHYDROGENASE-RXN
xref: RHEA:10399
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050019
name: L-arabinitol 4-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arabinitol + NAD(+) = L-xylulose + H(+) + NADH." [EC:1.1.1.12, RHEA:16384]
xref: EC:1.1.1.12
xref: KEGG:R01903
xref: MetaCyc:L-ARABINITOL-4-DEHYDROGENASE-RXN
xref: RHEA:16384
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050020
name: L-arabinonate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arabinonate = 2-dehydro-3-deoxy-L-arabinonate + H(2)O." [EC:4.2.1.25, RHEA:20971]
synonym: "L-arabinonate hydro-lyase (2-dehydro-3-deoxy-L-arabinonate-forming)" EXACT [EC:4.2.1.25]
synonym: "L-arabinonate hydro-lyase activity" EXACT [EC:4.2.1.25]
synonym: "L-arabonate dehydrase activity" EXACT [EC:4.2.1.25]
synonym: "L-arabonate dehydratase activity" EXACT [EC:4.2.1.25]
xref: EC:4.2.1.25
xref: KEGG:R02522
xref: MetaCyc:L-ARABINONATE-DEHYDRATASE-RXN
xref: RHEA:20971
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050021
name: L-arabinonolactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arabinono-1,4-lactone + H(2)O = L-arabinonate + H(+)." [EC:3.1.1.15, RHEA:16220]
synonym: "L-arabinono-1,4-lactone lactonohydrolase activity" EXACT [EC:3.1.1.15]
xref: EC:3.1.1.15
xref: KEGG:R02526
xref: MetaCyc:L-ARABINONOLACTONASE-RXN
xref: RHEA:16220
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0050022
name: L-arabinose 1-dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arabinose + NAD+ = L-arabinono-1,4-lactone + NADH." [EC:1.1.1.46, MetaCyc:L-ARABINOSE-1-DEHYDROGENASE-RXN]
synonym: "L-arabinose 1-dehydrogenase activity" BROAD []
synonym: "L-arabinose:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.46]
xref: EC:1.1.1.46
xref: MetaCyc:L-ARABINOSE-1-DEHYDROGENASE-RXN
xref: RHEA:17928
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050023
name: L-fuconate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H(2)O." [EC:4.2.1.68, RHEA:22775]
synonym: "L-fuconate hydratase activity" EXACT []
synonym: "L-fuconate hydro-lyase (2-dehydro-3-deoxy-L-fuconate-forming)" EXACT [EC:4.2.1.68]
synonym: "L-fuconate hydro-lyase activity" EXACT [EC:4.2.1.68]
xref: EC:4.2.1.68
xref: KEGG:R03688
xref: MetaCyc:L-FUCONATE-HYDRATASE-RXN
xref: RHEA:22775
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050024
name: L-galactonolactone oxidase activity
namespace: molecular_function
alt_id: GO:0033733
def: "Catalysis of the reaction: L-galactono-1,4-lactone + O(2) = L-ascorbate + H(2)O(2) + H(+)." [EC:1.3.3.12, RHEA:20620]
synonym: "L-galactono-1,4-lactone oxidase activity" EXACT [EC:1.3.3.12]
synonym: "L-galactono-1,4-lactone:oxygen 3-oxidoreductase activity" EXACT [EC:1.3.3.12]
synonym: "L-xylono-1,4-lactone oxidase activity" EXACT [EC:1.3.3.12]
xref: EC:1.3.3.12
xref: KEGG:R00643
xref: MetaCyc:1.3.3.12-RXN
xref: RHEA:20620
is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0050025
name: L-glutamate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamate + O2 + H2O = 2-oxoglutarate + NH3 + H2O2." [EC:1.4.3.11, MetaCyc:L-GLUTAMATE-OXIDASE-RXN]
subset: gosubset_prok
synonym: "glutamate (acceptor) dehydrogenase activity" EXACT [EC:1.4.3.11]
synonym: "glutamate oxidase activity" EXACT [EC:1.4.3.11]
synonym: "glutamic acid oxidase activity" EXACT [EC:1.4.3.11]
synonym: "glutamic dehydrogenase (acceptor)" EXACT [EC:1.4.3.11]
synonym: "L-glutamate:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.11]
synonym: "L-glutamic acid oxidase activity" EXACT [EC:1.4.3.11]
xref: EC:1.4.3.11
xref: MetaCyc:L-GLUTAMATE-OXIDASE-RXN
xref: RHEA:20731
is_a: GO:0001716 ! L-amino-acid oxidase activity

[Term]
id: GO:0050026
name: L-glycol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: an L-glycol + NAD(P)+ = a 2-hydroxycarbonyl compound + NAD(P)H + H+." [EC:1.1.1.185, MetaCyc:L-GLYCOL-DEHYDROGENASE-RXN]
synonym: "glycol (nicotinamide adenine dinucleotide (phosphate)) dehydrogenase activity" EXACT [EC:1.1.1.185]
synonym: "L-(+)-glycol:NAD(P) oxidoreductase activity" EXACT [EC:1.1.1.185]
synonym: "L-glycol:NAD(P) dehydrogenase activity" EXACT [EC:1.1.1.185]
synonym: "L-glycol:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.185]
xref: EC:1.1.1.185
xref: MetaCyc:L-GLYCOL-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050027
name: obsolete L-idonate 2-dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: L-idonate + NADP+ = 5-dehydro-D-gluconate + NADPH." [EC:1.1.1.128, MetaCyc:L-IDONATE-2-DEHYDROGENASE-RXN]
comment: This term was made obsolete because EC:1.1.1.128 was deleted: the reaction described is covered by EC 1.1.1.264.
synonym: "5-keto-D-gluconate 2-reductase activity" EXACT [EC:1.1.1.128]
synonym: "5-ketogluconate 2-reductase activity" EXACT [EC:1.1.1.128]
synonym: "5-ketoglucono-idono-reductase activity" EXACT [EC:1.1.1.128]
synonym: "5KGR" RELATED [EC:1.1.1.128]
synonym: "L-idonate 2-dehydrogenase activity" EXACT []
synonym: "L-idonate dehydrogenase activity" EXACT [EC:1.1.1.128]
synonym: "L-idonate:NADP+ 2-oxidoreductase activity" EXACT [EC:1.1.1.128]
synonym: "reductase, 5-ketogluconate 5- (L-idonate-forming)" EXACT [EC:1.1.1.128]
xref: EC:1.1.1.128
xref: MetaCyc:L-IDONATE-2-DEHYDROGENASE-RXN
xref: RHEA:21179
is_obsolete: true
consider: GO:0050572

[Term]
id: GO:0050028
name: L-lysine-lactamase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-2-aminohexano-6-lactam + H(2)O = L-lysine." [EC:3.5.2.11, RHEA:21391]
synonym: "L-alpha-aminocaprolactam hydrolase activity" EXACT [EC:3.5.2.11]
synonym: "L-lysinamidase activity" EXACT [EC:3.5.2.11]
synonym: "L-lysine-1,6-lactam lactamhydrolase activity" EXACT [EC:3.5.2.11]
xref: EC:3.5.2.11
xref: KEGG:R00463
xref: MetaCyc:L-LYSINE-LACTAMASE-RXN
xref: RHEA:21391
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0050029
name: L-lysine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-lysine + H(2)O + O(2) = 6-amino-2-oxohexanoate + H(2)O(2) + NH(4)(+)." [EC:1.4.3.14, RHEA:14440]
synonym: "L-lysine alpha-oxidase activity" EXACT [EC:1.4.3.14]
synonym: "L-lysine:oxygen 2-oxidoreductase (deaminating)" EXACT [EC:1.4.3.14]
synonym: "L-lysyl-alpha-oxidase activity" EXACT [EC:1.4.3.14]
xref: EC:1.4.3.14
xref: KEGG:R00447
xref: MetaCyc:L-LYSINE-OXIDASE-RXN
xref: MetaCyc:PWY-5311
xref: RHEA:14440
is_a: GO:0001716 ! L-amino-acid oxidase activity

[Term]
id: GO:0050030
name: L-pipecolate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-pipecolate + acceptor = delta1-piperideine-6-carboxylate + reduced acceptor. Delta1-piperideine-6-carboxylate is also known as 2,3,4,5-tetrahydropyridine-2-carboxylate." [EC:1.5.99.3, MetaCyc:L-PIPECOLATE-DEHYDROGENASE-RXN]
synonym: "L-pipecolate:(acceptor) 1,6-oxidoreductase activity" EXACT [EC:1.5.99.3]
synonym: "L-pipecolate:acceptor 1,6-oxidoreductase activity" EXACT [EC:1.5.99.3]
xref: EC:1.5.99.3
xref: MetaCyc:L-PIPECOLATE-DEHYDROGENASE-RXN
xref: RHEA:19780
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0050031
name: L-pipecolate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-pipecolate + O(2) = 2,3,4,5-tetrahydropyridine-2-carboxylate + H(2)O(2) + H(+). Delta1-piperideine-6-carboxylate is also known as 2,3,4,5-tetrahydropyridine-2-carboxylate." [EC:1.5.3.7, RHEA:11995]
synonym: "L-pipecolate:oxygen 1,6-oxidoreductase activity" EXACT [EC:1.5.3.7]
synonym: "L-pipecolic acid oxidase activity" EXACT [EC:1.5.3.7]
xref: EC:1.5.3.7
xref: KEGG:R02204
xref: MetaCyc:L-PIPECOLATE-OXIDASE-RXN
xref: RHEA:11995
is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor

[Term]
id: GO:0050032
name: L-rhamnonate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-rhamnonate = 2-dehydro-3-deoxy-L-rhamnonate + H(2)O." [EC:4.2.1.90, RHEA:23083]
synonym: "L-rhamnonate hydro-lyase (2-dehydro-3-deoxy-L-rhamnonate-forming)" EXACT [EC:4.2.1.90]
synonym: "L-rhamnonate hydro-lyase activity" EXACT [EC:4.2.1.90]
xref: EC:4.2.1.90
xref: KEGG:R03774
xref: MetaCyc:L-RHAMNONATE-DEHYDRATASE-RXN
xref: RHEA:23083
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050033
name: L-rhamnono-1,4-lactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-rhamnono-1,4-lactone + H(2)O = L-rhamnonate + H(+)." [EC:3.1.1.65, RHEA:10291]
synonym: "L-rhamno-gamma-lactonase activity" EXACT [EC:3.1.1.65]
synonym: "L-rhamnono-1,4-lactone lactonohydrolase activity" EXACT [EC:3.1.1.65]
synonym: "L-rhamnono-gamma-lactonase activity" EXACT [EC:3.1.1.65]
xref: EC:3.1.1.65
xref: KEGG:R03772
xref: MetaCyc:L-RHAMNONO-14-LACTONASE-RXN
xref: RHEA:10291
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0050034
name: L-rhamnose 1-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-rhamnofuranose + NAD(+) = L-rhamnono-1,4-lactone + H(+) + NADH." [EC:1.1.1.173, RHEA:12652]
synonym: "L-rhamnofuranose:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.173]
xref: EC:1.1.1.173
xref: KEGG:R03942
xref: MetaCyc:L-RHAMNOSE-1-DEHYDROGENASE-RXN
xref: RHEA:12652
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050035
name: L-sorbose oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-sorbose + O(2) = 5-dehydro-D-fructose + H(2)O(2)." [EC:1.1.3.11, RHEA:17856]
synonym: "L-sorbose:oxygen 5-oxidoreductase activity" EXACT [EC:1.1.3.11]
xref: EC:1.1.3.11
xref: KEGG:R01695
xref: MetaCyc:L-SORBOSE-OXIDASE-RXN
xref: RHEA:17856
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0050036
name: L-threonate 3-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-threonate + NAD(+) = 3-dehydro-L-threonate + H(+) + NADH." [EC:1.1.1.129, RHEA:23379]
synonym: "L-threonate:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.129]
synonym: "L-threonic acid dehydrogenase activity" EXACT [EC:1.1.1.129]
synonym: "threonate dehydrogenase activity" EXACT [EC:1.1.1.129]
xref: EC:1.1.1.129
xref: KEGG:R03733
xref: MetaCyc:L-THREONATE-3-DEHYDROGENASE-RXN
xref: RHEA:23379
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050037
name: L-xylose 1-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: aldehydo-L-xylose + NADP(+) = L-xylono-1,4-lactone + H(+) + NADPH." [EC:1.1.1.113, RHEA:15792]
synonym: "L-xylose dehydrogenase activity" EXACT [EC:1.1.1.113]
synonym: "L-xylose:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.113]
synonym: "NADPH-xylose reductase activity" EXACT [EC:1.1.1.113]
xref: EC:1.1.1.113
xref: KEGG:R03586
xref: MetaCyc:L-XYLOSE-1-DEHYDROGENASE-RXN
xref: RHEA:15792
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050038
name: L-xylulose reductase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP(+) + xylitol = L-xylulose + H(+) + NADPH." [EC:1.1.1.10, RHEA:17028]
synonym: "L-xylulose reductase activity" BROAD []
xref: EC:1.1.1.10
xref: KEGG:R01904
xref: MetaCyc:L-XYLULOSE-REDUCTASE-RXN
xref: RHEA:17028
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050039
name: lactaldehyde reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP(+) + propane-1,2-diol = (S)-lactaldehyde + H(+) + NADPH." [EC:1.1.1.55, RHEA:15888]
synonym: "1,2-propanediol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.55]
synonym: "lactaldehyde (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.1.1.55]
synonym: "NADP-1,2-propanediol dehydrogenase activity" EXACT [EC:1.1.1.55]
synonym: "propane-1,2-diol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.55]
synonym: "propanediol dehydrogenase activity" EXACT [EC:1.1.1.55]
xref: EC:1.1.1.55
xref: KEGG:R02259
xref: MetaCyc:LACTALDEHYDE-REDUCTASE-NADPH-RXN
xref: RHEA:15888
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050040
name: lactate 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-lactate + O(2) = acetate + CO(2) + H(2)O." [EC:1.13.12.4, RHEA:16516]
subset: gosubset_prok
synonym: "(S)-lactate:oxygen 2-oxidoreductase (decarboxylating)" EXACT [EC:1.13.12.4]
synonym: "L-lactate monooxygenase activity" EXACT [EC:1.13.12.4]
synonym: "L-lactate-2-monooxygenase activity" EXACT [EC:1.13.12.4]
synonym: "lactate monooxygenase activity" EXACT [EC:1.13.12.4]
synonym: "lactate oxidase activity" EXACT [EC:1.13.12.4]
synonym: "lactate oxidative decarboxylase activity" EXACT [EC:1.13.12.4]
synonym: "lactate oxygenase activity" EXACT [EC:1.13.12.4]
synonym: "lactic oxidase activity" EXACT [EC:1.13.12.4]
synonym: "lactic oxygenase activity" EXACT [EC:1.13.12.4]
xref: EC:1.13.12.4
xref: KEGG:R00319
xref: MetaCyc:LACTATE-2-MONOOXYGENASE-RXN
xref: RHEA:16516
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)

[Term]
id: GO:0050041
name: lactate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-lactate = acetaldehyde + formate." [EC:4.1.2.36, RHEA:17912]
synonym: "(S)-lactate acetaldehyde-lyase (formate-forming)" EXACT [EC:4.1.2.36]
synonym: "(S)-lactate acetaldehyde-lyase activity" EXACT [EC:4.1.2.36]
synonym: "lactate synthase activity" EXACT [EC:4.1.2.36]
xref: EC:4.1.2.36
xref: KEGG:R00753
xref: MetaCyc:LACTATE-ALDOLASE-RXN
xref: RHEA:17912
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0050042
name: lactate-malate transhydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-lactate + oxaloacetate = malate + pyruvate." [EC:1.1.99.7, RHEA:10987]
synonym: "(S)-lactate:oxaloacetate oxidoreductase activity" EXACT [EC:1.1.99.7]
synonym: "malate-lactate transhydrogenase activity" EXACT [EC:1.1.99.7]
xref: EC:1.1.99.7
xref: KEGG:R01447
xref: MetaCyc:LACTATE-MALATE-TRANSHYDROGENASE-RXN
xref: RHEA:10987
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0050043
name: lactate racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-lactate = (R)-lactate." [EC:5.1.2.1, RHEA:10963]
synonym: "hydroxyacid racemase activity" EXACT [EC:5.1.2.1]
synonym: "lactic acid racemase activity" EXACT [EC:5.1.2.1]
synonym: "lacticoracemase activity" EXACT [EC:5.1.2.1]
xref: EC:5.1.2.1
xref: KEGG:R01450
xref: MetaCyc:LACTATE-RACEMASE-RXN
xref: RHEA:10963
is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives

[Term]
id: GO:0050044
name: galactose-6-phosphate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-galactose 6-phosphate = D-tagatose 6-phosphate." [EC:5.3.1.26, RHEA:13036]
subset: gosubset_prok
synonym: "D-galactose-6-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.26]
synonym: "D-galactose-6-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.26]
xref: EC:5.3.1.26
xref: KEGG:R03240
xref: MetaCyc:LACTOSE-6-PHOSPHATE-ISOMERASE-RXN
xref: RHEA:13036
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0050045
name: laminaribiose phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-beta-D-glucosyl-D-glucose + phosphate = D-glucose + alpha-D-glucose 1-phosphate." [EC:2.4.1.31, MetaCyc:LAMINARIBIOSE-PHOSPHORYLASE-RXN]
synonym: "3-beta-D-glucosyl-D-glucose:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.31]
xref: EC:2.4.1.31
xref: MetaCyc:LAMINARIBIOSE-PHOSPHORYLASE-RXN
xref: RHEA:16620
is_a: GO:0004645 ! phosphorylase activity

[Term]
id: GO:0050046
name: lathosterol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-alpha-cholest-7-en-3-beta-ol + O2 = cholesta-5,7-dien-3-beta-ol + H2O2." [EC:1.14.21.6, MetaCyc:LATHOSTEROL-OXIDASE-RXN]
synonym: "5-DES" RELATED [EC:1.14.21.6]
synonym: "5alpha-cholest-7-en-3beta-ol, NAD(P)H:oxygen 5-oxidoreductase activity" EXACT [EC:1.14.21.6]
synonym: "delta7-sterol 5-desaturase activity" EXACT [EC:1.14.21.6]
synonym: "delta7-sterol delta5-dehydrogenase activity" EXACT [EC:1.14.21.6]
synonym: "delta7-sterol-C5(6)-desaturase activity" EXACT [EC:1.14.21.6]
synonym: "lathosterol 5-desaturase activity" EXACT [EC:1.14.21.6]
xref: EC:1.14.21.6
xref: MetaCyc:1.14.21.6-RXN
is_a: GO:0046996 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NAD(P)H as one donor, and the other dehydrogenated
is_a: GO:0070704 ! sterol desaturase activity

[Term]
id: GO:0050047
name: leucine 2,3-aminomutase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-leucine = (3R)-beta-leucine." [EC:5.4.3.7, RHEA:10287]
synonym: "(2S)-alpha-leucine 2,3-aminomutase activity" EXACT [EC:5.4.3.7]
xref: EC:5.4.3.7
xref: KEGG:R01091
xref: MetaCyc:LEUCINE-23-AMINOMUTASE-RXN
xref: RHEA:10287
is_a: GO:0016869 ! intramolecular transferase activity, transferring amino groups

[Term]
id: GO:0050048
name: L-leucine:2-oxoglutarate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate." [EC:2.6.1.6, MetaCyc:LEUCINE-AMINOTRANSFERASE-RXN]
synonym: "L-leucine aminotransferase activity" BROAD [EC:2.6.1.6]
synonym: "leucine 2-oxoglutarate transaminase activity" EXACT [EC:2.6.1.6]
synonym: "leucine aminotransferase activity" BROAD []
synonym: "leucine transaminase activity" BROAD [EC:2.6.1.6]
synonym: "leucine-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.6]
xref: EC:2.6.1.6
xref: MetaCyc:LEUCINE-AMINOTRANSFERASE-RXN
xref: RHEA:18324
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0050049
name: leucine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-leucine + H2O + NAD+ = 4-methyl-2-oxopentanoate + NH3 + NADH." [EC:1.4.1.9, MetaCyc:LEUCINE-DEHYDROGENASE-RXN]
subset: gosubset_prok
synonym: "L-leucine dehydrogenase activity" EXACT [EC:1.4.1.9]
synonym: "L-leucine:NAD+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.9]
synonym: "L-leucine:NAD+ oxidoreductase, deaminating" EXACT [EC:1.4.1.9]
synonym: "LeuDH activity" EXACT [EC:1.4.1.9]
xref: EC:1.4.1.9
xref: MetaCyc:LEUCINE-DEHYDROGENASE-RXN
xref: RHEA:12223
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050050
name: leucine N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-leucine + acetyl-CoA = N-acetyl-L-leucine + CoA + H(+)." [EC:2.3.1.66, RHEA:20092]
synonym: "acetyl-CoA:L-leucine N-acetyltransferase activity" EXACT [EC:2.3.1.66]
synonym: "leucine acetyltransferase activity" EXACT [EC:2.3.1.66]
xref: EC:2.3.1.66
xref: KEGG:R01089
xref: MetaCyc:LEUCINE-N-ACETYLTRANSFERASE-RXN
xref: RHEA:20092
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0050051
name: leukotriene-B4 20-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + NADPH + H+ + O2 = (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + NADP+ + H2O." [EC:1.14.13.30, MetaCyc:LEUKOTRIENE-B4-20-MONOOXYGENASE-RXN]
synonym: "(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate,NADPH:oxygen oxidoreductase (20-hydroxylating)" EXACT [EC:1.14.13.30]
synonym: "leucotriene-B4 omega-hydroxylase activity" EXACT [EC:1.14.13.30]
synonym: "leukotriene-B(4) 20-hydroxylase activity" EXACT [EC:1.14.13.30]
synonym: "leukotriene-B(4) omega-hydroxylase activity" EXACT [EC:1.14.13.30]
synonym: "leukotriene-B4 20-hydroxylase activity" EXACT []
synonym: "leukotriene-B4 omega-hydroxylase activity" EXACT [EC:1.14.13.30]
synonym: "LTB(4) 20-hydroxylase activity" EXACT [EC:1.14.13.30]
synonym: "LTB(4) omega-hydroxylase activity" EXACT [EC:1.14.13.30]
synonym: "LTB4 20-hydroxylase activity" EXACT [EC:1.14.13.30]
synonym: "LTB4 omega-hydroxylase activity" EXACT [EC:1.14.13.30]
xref: EC:1.14.13.30
xref: MetaCyc:LEUKOTRIENE-B4-20-MONOOXYGENASE-RXN
xref: RHEA:22179
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
relationship: part_of GO:0036101 ! leukotriene B4 catabolic process

[Term]
id: GO:0050052
name: leukotriene-E4 20-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(+) + leukotriene E(4) + NADPH + O(2) = 20-hydroxy-leukotriene E(4) + H(2)O + NADP(+)." [EC:1.14.13.34, RHEA:24123]
synonym: "(7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate,NADPH:oxygen oxidoreductase (20-hydroxylating)" EXACT [EC:1.14.13.34]
synonym: "leukotriene-E(4) omega-hydroxylase activity" EXACT [EC:1.14.13.34]
synonym: "leukotriene-E4 omega-hydroxylase activity" EXACT [EC:1.14.13.34]
synonym: "leukotriene-E4 w-hydroxylase activity" EXACT []
xref: EC:1.14.13.34
xref: KEGG:R04256
xref: MetaCyc:LEUKOTRIENE-E4-20-MONOOXYGENASE-RXN
xref: RHEA:24123
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050053
name: levansucrase activity
namespace: molecular_function
def: "Catalysis of the reaction: sucrose + 2,6-beta-D-fructosyl(n) = glucose + 2,6-beta-D-fructosyl(n+1)." [EC:2.4.1.10, MetaCyc:LEVANSUCRASE-RXN]
subset: gosubset_prok
synonym: "beta-2,6-fructan:D-glucose 1-fructosyltransferase activity" EXACT [EC:2.4.1.10]
synonym: "beta-2,6-fructosyltransferase activity" EXACT [EC:2.4.1.10]
synonym: "sucrose 6-fructosyl transferase activity" EXACT [EC:2.4.1.10]
synonym: "sucrose 6-fructosyltransferase activity" EXACT [EC:2.4.1.10]
synonym: "sucrose:2,6-beta-D-fructan 6-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.10]
xref: EC:2.4.1.10
xref: MetaCyc:LEVANSUCRASE-RXN
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0050054
name: lignostilbene alpha beta-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene + O(2) = 2 vanillin." [EC:1.13.11.43, RHEA:21343]
synonym: "1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene:oxygen oxidoreductase (alphabeta-bond-cleaving)" EXACT [EC:1.13.11.43]
synonym: "lignostilbene ab-dioxygenase activity" EXACT []
synonym: "lignostilbene alphabeta-dioxygenase activity" EXACT [EC:1.13.11.43]
xref: EC:1.13.11.43
xref: KEGG:R00043
xref: MetaCyc:LIGNOSTILBENE-ALPHA-BETA-DIOXYGENASE-RXN
xref: RHEA:21343
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0050055
name: limonin-D-ring-lactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: limonoate D-ring-lactone + H2O = limonoate." [EC:3.1.1.36, MetaCyc:LIMONIN-D-RING-LACTONASE-RXN]
synonym: "limonin lactone hydrolase activity" EXACT [EC:3.1.1.36]
synonym: "limonin-D-ring-lactone hydrolase activity" EXACT [EC:3.1.1.36]
synonym: "limonoate-D-ring-lactone lactonohydrolase activity" EXACT [EC:3.1.1.36]
xref: EC:3.1.1.36
xref: MetaCyc:LIMONIN-D-RING-LACTONASE-RXN
xref: RHEA:10899
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0050056
name: linalool 8-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: AH(2) + linalool + O(2) = (2E)-2,6-dimethylocta-2,7-diene-1,6-diol + A + H(2)O." [EC:1.14.99.28, RHEA:20763]
subset: gosubset_prok
synonym: "3,7-dimethylocta-1,6-dien-3-ol,hydrogen-donor:oxygen oxidoreductase (8-hydroxylating)" EXACT [EC:1.14.99.28]
xref: EC:1.14.99.28
xref: KEGG:R04366
xref: MetaCyc:LINALOOL-8-MONOOXYGENASE-RXN
xref: RHEA:20763
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0050057
name: linamarin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + 2-hydroxy-2-methylpropanenitrile = UDP + linamarin." [EC:2.4.1.63, MetaCyc:LINAMARIN-SYNTHASE-RXN]
synonym: "UDP glucose ketone cyanohydrin glucosyltransferase activity" EXACT [EC:2.4.1.63]
synonym: "UDP-glucose:2-hydroxy-2-methylpropanenitrile beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.63]
synonym: "UDPglucose:2-hydroxy-2-methylpropanenitrile beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.63]
synonym: "UDPglucose:ketone cyanohydrin beta-glucosyltransferase activity" EXACT [EC:2.4.1.63]
synonym: "uridine diphosphate-glucose-ketone cyanohydrin beta-glucosyltransferase activity" EXACT [EC:2.4.1.63]
synonym: "uridine diphosphoglucose-ketone cyanohydrin glucosyltransferase activity" EXACT [EC:2.4.1.63]
synonym: "uridine diphosphoglucose-ketone glucosyltransferase activity" EXACT [EC:2.4.1.63]
xref: EC:2.4.1.63
xref: MetaCyc:LINAMARIN-SYNTHASE-RXN
xref: RHEA:20012
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0050058
name: linoleate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: linoleate = 9-cis,11-trans-octadecadienoate." [EC:5.2.1.5, RHEA:17384]
synonym: "linoleate delta12-cis-delta11-trans-isomerase activity" EXACT [EC:5.2.1.5]
synonym: "linoleic acid isomerase activity" EXACT [EC:5.2.1.5]
xref: EC:5.2.1.5
xref: KEGG:R03627
xref: MetaCyc:LINOLEATE-ISOMERASE-RXN
xref: RHEA:17384
is_a: GO:0016859 ! cis-trans isomerase activity

[Term]
id: GO:0050059
name: lombricine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + lombricine = ADP + N-phospholombricine." [EC:2.7.3.5, MetaCyc:LOMBRICINE-KINASE-RXN]
synonym: "ATP:lombricine N-phosphotransferase activity" EXACT [EC:2.7.3.5]
xref: EC:2.7.3.5
xref: MetaCyc:LOMBRICINE-KINASE-RXN
xref: RHEA:23295
is_a: GO:0016301 ! kinase activity
is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor

[Term]
id: GO:0050060
name: long-chain-alcohol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a long-chain alcohol + 2 NAD+ + H2O = a long-chain carboxylate + 2 NADH." [EC:1.1.1.192, MetaCyc:LONG-CHAIN-ALCOHOL-DEHYDROGENASE-RXN]
synonym: "fatty alcohol oxidoreductase activity" EXACT [EC:1.1.1.192]
synonym: "long-chain alcohol dehydrogenase activity" EXACT [EC:1.1.1.192]
synonym: "long-chain-alcohol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.192]
xref: EC:1.1.1.192
xref: MetaCyc:LONG-CHAIN-ALCOHOL-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050061
name: long-chain-aldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a long-chain aldehyde + NAD+ = a long-chain carboxylate + NADH + H+. A long-chain aldehyde is one with more than 12 carbons." [EC:1.2.1.48, MetaCyc:LONG-CHAIN-ALDEHYDE-DEHYDROGENASE-RXN]
synonym: "fatty aldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.48]
synonym: "long-chain aliphatic aldehyde dehydrogenase activity" EXACT [EC:1.2.1.48]
synonym: "long-chain fatty aldehyde dehydrogenase activity" EXACT [EC:1.2.1.48]
synonym: "long-chain-aldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.48]
xref: EC:1.2.1.48
xref: MetaCyc:LONG-CHAIN-ALDEHYDE-DEHYDROGENASE-RXN
xref: UM-BBD_reactionID:r1404
is_a: GO:0004029 ! aldehyde dehydrogenase (NAD) activity

[Term]
id: GO:0050062
name: long-chain-fatty-acyl-CoA reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: a long-chain aldehyde + CoA + NADP+ = a long-chain acyl-CoA + NADPH." [EC:1.2.1.50, MetaCyc:LONG-CHAIN-FATTY-ACYL-COA-REDUCTASE-RXN]
subset: gosubset_prok
synonym: "acyl coenzyme A reductase activity" EXACT [EC:1.2.1.50]
synonym: "long-chain fatty acyl CoA reductase activity" EXACT [GOC:curators]
synonym: "long-chain fatty acyl-CoA reductase activity" EXACT [GOC:mah]
synonym: "long-chain-aldehyde:NADP+ oxidoreductase (acyl-CoA-forming)" EXACT [EC:1.2.1.50]
xref: EC:1.2.1.50
xref: MetaCyc:LONG-CHAIN-FATTY-ACYL-COA-REDUCTASE-RXN
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050063
name: low-density-lipoprotein particle receptor kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + low-density lipoprotein L-serine = ADP + low-density lipoprotein O-phospho-L-serine." [EC:2.7.11.29, MetaCyc:LOW-DENSITY-LIPOPROTEIN-KINASE-RXN]
synonym: "[low-density lipoprotein receptor] kinase activity" EXACT []
synonym: "ATP:low-density-lipoprotein receptor-L-serine O-phosphotransferase activity" EXACT [EC:2.7.11.29]
synonym: "ATP:low-density-lipoprotein-L-serine O-phosphotransferase activity" EXACT [EC:2.7.11.29]
synonym: "LDL receptor kinase activity" EXACT [EC:2.7.11.29]
synonym: "low-density lipoprotein receptor kinase activity" EXACT [EC:2.7.11.29]
synonym: "low-density-lipoprotein kinase activity" BROAD [EC:2.7.11.29]
synonym: "low-density-lipoprotein receptor kinase (phosphorylating) activity" EXACT [EC:2.7.11.29]
synonym: "low-density-lipoprotein receptor kinase activity" EXACT [GOC:dph]
synonym: "STK7" RELATED [EC:2.7.11.29]
xref: EC:2.7.11.29
xref: MetaCyc:2.7.11.29-RXN
is_a: GO:0004672 ! protein kinase activity

[Term]
id: GO:0050064
name: luteolin 7-O-glucuronosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: luteolin + UDP-alpha-D-glucuronate = luteolin 7-O-beta-D-glucosiduronate + UDP." [EC:2.4.1.189, RHEA:10571]
synonym: "LGT" RELATED [EC:2.4.1.189]
synonym: "luteolin 7-O-glucoronosyltransferase activity" EXACT []
synonym: "UDP-glucuronate:luteolin 7-O-glucuronosyltransferase activity" EXACT [EC:2.4.1.189]
synonym: "UDPglucuronate:luteolin 7-O-glucuronosyltransferase activity" EXACT [EC:2.4.1.189]
synonym: "uridine diphosphoglucuronate-luteolin 7-O-glucuronosyltransferase activity" EXACT [EC:2.4.1.189]
xref: EC:2.4.1.189
xref: KEGG:R03589
xref: MetaCyc:LUTEOLIN-7-O-GLUCORONOSYLTRANSFERASE-RXN
xref: RHEA:10571
is_a: GO:0015020 ! glucuronosyltransferase activity

[Term]
id: GO:0050065
name: lysine-pyruvate 6-transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-lysine + pyruvate = L-alanine + L-allysine." [EC:2.6.1.71, RHEA:19396]
synonym: "L-lysine:pyruvate aminotransferase activity" EXACT [EC:2.6.1.71]
synonym: "Lys-AT" RELATED [EC:2.6.1.71]
synonym: "lysine--pyruvate 6-aminotransferase activity" EXACT []
synonym: "lysine-pyruvate aminotransferase activity" EXACT [EC:2.6.1.71]
xref: EC:2.6.1.71
xref: KEGG:R00453
xref: MetaCyc:LYSINE--PYRUVATE-6-AMINOTRANSFERASE-RXN
xref: MetaCyc:PWY-5324
xref: RHEA:19396
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0050066
name: lysine 2,3-aminomutase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-lysine = (3S)-3,6-diaminohexanoate." [EC:5.4.3.2, RHEA:19180]
subset: gosubset_prok
synonym: "L-lysine 2,3-aminomutase activity" EXACT [EC:5.4.3.2]
xref: EC:5.4.3.2
xref: KEGG:R00461
xref: MetaCyc:LYSINE-23-AMINOMUTASE-RXN
xref: RHEA:19180
is_a: GO:0016869 ! intramolecular transferase activity, transferring amino groups
is_a: GO:0070283 ! radical SAM enzyme activity

[Term]
id: GO:0050067
name: lysine 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-lysine + O(2) = 5-aminopentanamide + CO(2) + H(2)O." [EC:1.13.12.2, RHEA:14604]
synonym: "L-lysine-2-monooxygenase activity" EXACT [EC:1.13.12.2]
synonym: "L-lysine:oxygen 2-oxidoreductase (decarboxylating)" EXACT [EC:1.13.12.2]
synonym: "lysine monooxygenase activity" EXACT [EC:1.13.12.2]
synonym: "lysine oxygenase activity" EXACT [EC:1.13.12.2]
xref: EC:1.13.12.2
xref: KEGG:R00449
xref: MetaCyc:LYSINE-2-MONOOXYGENASE-RXN
xref: RHEA:14604
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)

[Term]
id: GO:0050068
name: lysine carbamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-lysine + carbamoyl phosphate = L-homocitrulline + H(+) + phosphate." [EC:2.1.3.8, RHEA:17124]
synonym: "carbamoyl-phosphate:L-lysine carbamoyltransferase activity" EXACT [EC:2.1.3.8]
synonym: "lysine transcarbamylase activity" EXACT [EC:2.1.3.8]
xref: EC:2.1.3.8
xref: KEGG:R01396
xref: MetaCyc:LYSINE-CARBAMOYLTRANSFERASE-RXN
xref: RHEA:17124
is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity

[Term]
id: GO:0050069
name: lysine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-lysine + NAD+ = 1,2-didehydropiperidine-2-carboxylate + NH3 + NADH." [EC:1.4.1.15, MetaCyc:LYSINE-DEHYDROGENASE-RXN]
synonym: "L-lysine:NAD+ oxidoreductase (deaminating, cyclizing)" EXACT [EC:1.4.1.15]
xref: EC:1.4.1.15
xref: MetaCyc:LYSINE-DEHYDROGENASE-RXN
xref: RHEA:18508
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050070
name: lysolecithin acylmutase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine = 2-acyl-sn-glycero-3-phosphocholine." [EC:5.4.1.1, RHEA:24359]
synonym: "lysolecithin 2,3-acylmutase activity" EXACT [EC:5.4.1.1]
synonym: "lysolecithin migratase activity" RELATED [EC:5.4.1.1]
xref: EC:5.4.1.1
xref: KEGG:R03334
xref: MetaCyc:LYSOLECITHIN-ACYLMUTASE-RXN
xref: RHEA:24359
is_a: GO:0016867 ! intramolecular transferase activity, transferring acyl groups

[Term]
id: GO:0050071
name: lysyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-lysyl-tRNA + phosphatidylglycerol = tRNA + 3-phosphatidyl-1'-(3'-O-L-lysyl)glycerol." [EC:2.3.2.3, MetaCyc:LYSYLTRANSFERASE-RXN]
subset: gosubset_prok
synonym: "L-lysyl-tRNA:phosphatidylglycerol 3-O-lysyltransferase activity" EXACT [EC:2.3.2.3]
synonym: "L-lysyl-tRNA:phosphatidylglycerol O3-lysyltransferase activity" EXACT [EC:2.3.2.3]
xref: EC:2.3.2.3
xref: MetaCyc:LYSYLTRANSFERASE-RXN
is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups

[Term]
id: GO:0050072
name: m7G(5')pppN diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7-methylguanosine 5'-triphospho-5'-polynucleotide + H2O = 7-methylguanosine 5'-phosphate + polynucleotide." [EC:3.6.1.30, MetaCyc:M7G5PPPN-PYROPHOSPHATASE-RXN]
synonym: "7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity" EXACT [EC:3.6.1.30]
synonym: "decapase activity" RELATED [EC:3.6.1.30]
synonym: "M(7)G(5')pppN pyrophosphatase activity" EXACT []
synonym: "m7G(5')pppN pyrophosphatase activity" EXACT [EC:3.6.1.30]
xref: EC:3.6.1.30
xref: MetaCyc:M7G5PPPN-PYROPHOSPHATASE-RXN
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0050073
name: macrolide 2'-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + oleandomycin = ADP + 2 H(+) + oleandomycin 2'-O-phosphate." [EC:2.7.1.136, RHEA:18336]
synonym: "ATP:macrolide 2'-O-phosphotransferase activity" EXACT [EC:2.7.1.136]
xref: EC:2.7.1.136
xref: KEGG:R03780
xref: MetaCyc:MACROLIDE-2-KINASE-RXN
xref: RHEA:18336
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0050074
name: malate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + malate + CoA = ADP + phosphate + malyl-CoA." [EC:6.2.1.9, MetaCyc:MALATE--COA-LIGASE-RXN]
subset: gosubset_prok
synonym: "malate thiokinase activity" RELATED [EC:6.2.1.9]
synonym: "malate:CoA ligase (ADP-forming)" EXACT [EC:6.2.1.9]
synonym: "malyl coenzyme A synthetase activity" EXACT [EC:6.2.1.9]
synonym: "malyl-CoA synthetase activity" EXACT [EC:6.2.1.9]
xref: EC:6.2.1.9
xref: MetaCyc:MALATE--COA-LIGASE-RXN
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0050075
name: maleate hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-malate = H(2)O + maleate." [EC:4.2.1.31, RHEA:23695]
synonym: "(R)-malate hydro-lyase (maleate-forming)" EXACT [EC:4.2.1.31]
synonym: "(R)-malate hydro-lyase activity" EXACT [EC:4.2.1.31]
synonym: "D-malate hydro-lyase activity" EXACT [EC:4.2.1.31]
synonym: "malease activity" EXACT [EC:4.2.1.31]
xref: EC:4.2.1.31
xref: KEGG:R02419
xref: MetaCyc:MALEATE-HYDRATASE-RXN
xref: RHEA:23695
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050076
name: maleate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: maleate = fumarate." [EC:5.2.1.1, RHEA:13172]
subset: gosubset_prok
synonym: "maleate cis-trans-isomerase activity" EXACT [EC:5.2.1.1]
xref: EC:5.2.1.1
xref: KEGG:R01087
xref: MetaCyc:MALEATE-ISOMERASE-RXN
xref: RHEA:13172
is_a: GO:0016859 ! cis-trans isomerase activity

[Term]
id: GO:0050077
name: maleylpyruvate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-maleylpyruvate = 3-fumarylpyruvate." [EC:5.2.1.4, MetaCyc:MALEYLPYRUVATE-ISOMERASE-RXN]
subset: gosubset_prok
synonym: "3-maleylpyruvate cis-trans-isomerase activity" EXACT [EC:5.2.1.4]
xref: EC:5.2.1.4
xref: MetaCyc:MALEYLPYRUVATE-ISOMERASE-RXN
xref: RHEA:17396
is_a: GO:0016859 ! cis-trans isomerase activity

[Term]
id: GO:0050078
name: malonate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + malonate = acetate + malonyl-CoA." [EC:2.8.3.3, RHEA:18820]
synonym: "acetyl-CoA:malonate CoA-transferase activity" EXACT [EC:2.8.3.3]
synonym: "malonate coenzyme A-transferase activity" EXACT [EC:2.8.3.3]
xref: EC:2.8.3.3
xref: KEGG:R00743
xref: MetaCyc:MALONATE-COA-TRANSFERASE-RXN
xref: RHEA:18820
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0050079
name: acetylenecarboxylate hydratase activity, producing 3-oxopropanoate
namespace: molecular_function
alt_id: GO:0047607
def: "Catalysis of the reaction: 3-oxopropanoate = propynoate + H2O." [EC:4.2.1.27, MetaCyc:MALONATE-SEMIALDEHYDE-DEHYDRATASE-RXN]
comment: Note that this function was formerly EC:4.2.1.71.
synonym: "3-oxopropanoate hydro-lyase (propynoate-forming)" EXACT [EC:4.2.1.27]
synonym: "3-oxopropanoate hydro-lyase activity" EXACT [EC:4.2.1.27]
synonym: "acetylenecarboxylate hydratase activity" BROAD []
synonym: "acetylenecarboxylate hydratase activity, producing malonate-semialdehyde" EXACT []
synonym: "acetylenemonocarboxylate hydrase activity" EXACT [EC:4.2.1.27]
synonym: "acetylenemonocarboxylate hydratase activity" BROAD []
synonym: "acetylmonocarboxylic acid hydrase activity" EXACT [EC:4.2.1.27]
synonym: "alkynoate hydratase activity" BROAD []
synonym: "malonate-semialdehyde dehydratase activity" EXACT []
xref: EC:4.2.1.27
xref: MetaCyc:MALONATE-SEMIALDEHYDE-DEHYDRATASE-RXN
xref: RHEA:17960
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050080
name: malonyl-CoA decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: malonyl-CoA = acetyl-CoA + CO2." [EC:4.1.1.9, MetaCyc:MALONYL-COA-DECARBOXYLASE-RXN]
subset: gosubset_prok
synonym: "malonyl coenzyme A decarboxylase activity" EXACT [EC:4.1.1.9]
synonym: "malonyl-CoA carboxy-lyase (acetyl-CoA-forming)" EXACT [EC:4.1.1.9]
synonym: "malonyl-CoA carboxy-lyase activity" EXACT [EC:4.1.1.9]
xref: EC:4.1.1.9
xref: MetaCyc:MALONYL-COA-DECARBOXYLASE-RXN
xref: RHEA:18784
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050081
name: maltose-6'-phosphate glucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + maltose 6'-phosphate = D-glucose + D-glucose 6-phosphate." [EC:3.2.1.122, MetaCyc:MALTOSE-6-PHOSPHATE-GLUCOSIDASE-RXN]
subset: gosubset_prok
synonym: "maltose-6'-phosphate 6-phosphoglucohydrolase activity" EXACT [EC:3.2.1.122]
synonym: "phospho-alpha-glucosidase activity" EXACT [EC:3.2.1.122]
xref: EC:3.2.1.122
xref: MetaCyc:MALTOSE-6-PHOSPHATE-GLUCOSIDASE-RXN
xref: RHEA:20424
is_a: GO:0015926 ! glucosidase activity

[Term]
id: GO:0050082
name: maltose phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: maltose + phosphate = D-glucose + beta-D-glucose 1-phosphate." [EC:2.4.1.8, MetaCyc:MALTOSE-PHOSPHORYLASE-RXN]
subset: gosubset_prok
synonym: "maltose:phosphate 1-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.8]
xref: EC:2.4.1.8
xref: MetaCyc:MALTOSE-PHOSPHORYLASE-RXN
xref: RHEA:21119
is_a: GO:0004645 ! phosphorylase activity

[Term]
id: GO:0050083
name: malyl-CoA lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3S)-3-carboxy-3-hydroxypropanoyl-CoA = acetyl-CoA + glyoxylate." [EC:4.1.3.24, MetaCyc:MALYL-COA-LYASE-RXN]
synonym: "(3S)-3-carboxy-3-hydroxypropanoyl-CoA glyoxylate-lyase (acetyl-CoA-forming)" EXACT [EC:4.1.3.24]
synonym: "(3S)-3-carboxy-3-hydroxypropanoyl-CoA glyoxylate-lyase activity" EXACT [EC:4.1.3.24]
synonym: "malyl-coenzyme A lyase activity" EXACT [EC:4.1.3.24]
xref: EC:4.1.3.24
xref: MetaCyc:MALYL-COA-LYASE-RXN
xref: RHEA:16632
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0050084
name: mannitol-1-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-mannitol 1-phosphate + H(2)O = D-mannitol + 2 H(+) + phosphate." [EC:3.1.3.22, RHEA:19540]
synonym: "D-mannitol-1-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.22]
synonym: "mannitol-1-phosphate phosphatase activity" EXACT [EC:3.1.3.22]
xref: EC:3.1.3.22
xref: KEGG:R02167
xref: MetaCyc:MANNITOL-1-PHOSPHATASE-RXN
xref: RHEA:19540
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0050085
name: mannitol 2-dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-mannitol + NADP(+) = D-fructose + H(+) + NADPH." [EC:1.1.1.138, RHEA:16768]
synonym: "D-mannitol:NADP+ 2-oxidoreductase activity" EXACT [EC:1.1.1.138]
synonym: "NADP-dependent mannitol dehydrogenase activity" EXACT [EC:1.1.1.138]
xref: EC:1.1.1.138
xref: KEGG:R00870
xref: MetaCyc:MANNITOL-2-DEHYDROGENASE-NADP+-RXN
xref: RHEA:16768
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050086
name: mannitol 2-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-mannitol + NAD+ = D-fructose + NADH." [EC:1.1.1.67, MetaCyc:MANNITOL-2-DEHYDROGENASE-RXN]
subset: gosubset_prok
synonym: "D-mannitol dehydrogenase activity" EXACT [EC:1.1.1.67]
synonym: "D-mannitol:NAD+ 2-oxidoreductase activity" EXACT [EC:1.1.1.67]
xref: EC:1.1.1.67
xref: MetaCyc:MANNITOL-2-DEHYDROGENASE-RXN
xref: RHEA:12087
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050087
name: mannitol dehydrogenase (cytochrome) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-mannitol + ferricytochrome c = D-fructose + ferrocytochrome c." [EC:1.1.2.2, MetaCyc:MANNITOL-DEHYDROGENASE-CYTOCHROME-RXN]
synonym: "D-mannitol:ferricytochrome-c 2-oxidoreductase activity" EXACT [EC:1.1.2.2]
synonym: "polyol dehydrogenase activity" BROAD [EC:1.1.2.2]
xref: EC:1.1.2.2
xref: MetaCyc:MANNITOL-DEHYDROGENASE-CYTOCHROME-RXN
is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor

[Term]
id: GO:0050088
name: mannose-6-phosphate 6-reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-mannitol 1-phosphate + NADP(+) = D-mannose 6-phosphate + 3 H(+) + NADPH." [EC:1.1.1.224, RHEA:14928]
synonym: "6-phosphomannose reductase activity" EXACT [EC:1.1.1.224]
synonym: "D-mannitol-1-phosphate:NADP+ 6-oxidoreductase activity" EXACT [EC:1.1.1.224]
synonym: "mannose-6-phosphate reductase activity" EXACT [EC:1.1.1.224]
synonym: "NADP-dependent mannose-6-P:mannitol-1-P oxidoreductase activity" EXACT [EC:1.1.1.224]
synonym: "NADPH-dependent M6P reductase activity" EXACT [EC:1.1.1.224]
synonym: "NADPH-dependent mannose 6-phosphate reductase activity" EXACT [EC:1.1.1.224]
synonym: "NADPH-mannose-6-P reductase activity" EXACT [EC:1.1.1.224]
xref: EC:1.1.1.224
xref: KEGG:R01817
xref: MetaCyc:MANNOSE-6-PHOSPHATE-6-REDUCTASE-RXN
xref: RHEA:14928
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050089
name: mannose isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-mannose = D-fructose." [EC:5.3.1.7, RHEA:22607]
synonym: "D-mannose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.7]
synonym: "D-mannose isomerase activity" EXACT [EC:5.3.1.7]
synonym: "D-mannose ketol-isomerase activity" EXACT [EC:5.3.1.7]
xref: EC:5.3.1.7
xref: KEGG:R00877
xref: MetaCyc:MANNOSE-ISOMERASE-RXN
xref: RHEA:22607
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0050090
name: mannuronate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-mannonate + NAD(P)+ = D-mannuronate + NAD(P)H + H+." [EC:1.1.1.131, MetaCyc:MANNURONATE-REDUCTASE-RXN]
synonym: "D-mannonate:NAD(P)+ 6-oxidoreductase activity" EXACT [EC:1.1.1.131]
synonym: "D-mannonate:nicotinamide adenine dinucleotide (phosphate oxidoreductase (D-mannuronate-forming))" EXACT [EC:1.1.1.131]
synonym: "mannonate (nicotinamide adenine dinucleotide (phosphate))dehydrogenase activity" EXACT [EC:1.1.1.131]
synonym: "mannonate dehydrogenase (NAD(P)+)" EXACT [EC:1.1.1.131]
synonym: "mannonate dehydrogenase activity" EXACT [EC:1.1.1.131]
xref: EC:1.1.1.131
xref: MetaCyc:MANNURONATE-REDUCTASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050091
name: melilotate 3-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-(2-hydroxyphenyl)propanoate + H(+) + NADH + O(2) = 3-(2,3-dihydroxyphenyl)propanoate + H(2)O + NAD(+)." [EC:1.14.13.4, RHEA:17672]
synonym: "2-hydroxyphenylpropionate hydroxylase activity" EXACT [EC:1.14.13.4]
synonym: "2-hydroxyphenylpropionic hydroxylase activity" EXACT [EC:1.14.13.4]
synonym: "3-(2-hydroxyphenyl)propanoate,NADH:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.4]
synonym: "melilotate hydroxylase activity" EXACT []
synonym: "melilotic hydroxylase activity" EXACT [EC:1.14.13.4]
xref: EC:1.14.13.4
xref: KEGG:R03369
xref: MetaCyc:MELILOTATE-3-MONOOXYGENASE-RXN
xref: RHEA:17672
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050092
name: meso-tartrate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2R,3S)-tartrate + NAD(+) = dihydroxyfumarate + H(+) + NADH." [EC:1.3.1.7, RHEA:18556]
synonym: "meso-tartrate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.7]
xref: EC:1.3.1.7
xref: KEGG:R02544
xref: MetaCyc:MESO-TARTRATE-DEHYDROGENASE-RXN
xref: RHEA:18556
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050093
name: methanol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: methanol + NAD(+) = formaldehyde + H(+) + NADH." [EC:1.1.1.244, RHEA:19404]
subset: gosubset_prok
synonym: "methanol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.244]
xref: EC:1.1.1.244
xref: KEGG:R00605
xref: MetaCyc:METHANOL-DEHYDROGENASE-RXN
xref: RHEA:19404
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050094
name: methionine-glyoxylate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-methionine + glyoxylate = 4-methylthio-2-oxobutanoate + glycine." [EC:2.6.1.73, RHEA:22887]
synonym: "L-methionine:glyoxylate aminotransferase activity" EXACT [EC:2.6.1.73]
synonym: "methionine-glyoxylate aminotransferase activity" EXACT [EC:2.6.1.73]
synonym: "MGAT activity" EXACT [EC:2.6.1.73]
xref: EC:2.6.1.73
xref: KEGG:R00652
xref: MetaCyc:METHIONINE--GLYOXYLATE-TRANSAMINASE-RXN
xref: RHEA:22887
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0050095
name: methionine decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-methionine + H(+) = 3-methylthiopropanamine + CO(2)." [EC:4.1.1.57, RHEA:17760]
synonym: "L-methionine carboxy-lyase (3-methylthiopropanamine-forming)" EXACT [EC:4.1.1.57]
synonym: "L-methionine carboxy-lyase activity" EXACT [EC:4.1.1.57]
synonym: "L-methionine decarboxylase activity" EXACT [EC:4.1.1.57]
xref: EC:4.1.1.57
xref: KEGG:R00656
xref: MetaCyc:METHIONINE-DECARBOXYLASE-RXN
xref: RHEA:17760
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050096
name: methylaspartate ammonia-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: threo-3-methyl-L-aspartate = mesaconate + NH(4)(+)." [EC:4.3.1.2, RHEA:12832]
subset: gosubset_prok
synonym: "3-methylaspartase activity" EXACT [EC:4.3.1.2]
synonym: "beta-methylaspartase activity" EXACT [EC:4.3.1.2]
synonym: "L-threo-3-methylaspartate ammonia-lyase (mesaconate-forming)" EXACT [EC:4.3.1.2]
synonym: "L-threo-3-methylaspartate ammonia-lyase activity" EXACT [EC:4.3.1.2]
xref: EC:4.3.1.2
xref: KEGG:R03696
xref: MetaCyc:METHYLASPARTATE-AMMONIA-LYASE-RXN
xref: RHEA:12832
is_a: GO:0016841 ! ammonia-lyase activity

[Term]
id: GO:0050097
name: methylaspartate mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: threo-3-methyl-L-aspartate = L-glutamate." [EC:5.4.99.1, RHEA:12860]
subset: gosubset_prok
synonym: "b-methylaspartate-glutamate mutase activity" EXACT [EC:5.4.99.1]
synonym: "beta-methylaspartate-glutamate mutase activity" EXACT [EC:5.4.99.1]
synonym: "glutamate isomerase activity" EXACT [EC:5.4.99.1]
synonym: "glutamate mutase activity" EXACT [EC:5.4.99.1]
synonym: "glutamic acid isomerase activity" EXACT [EC:5.4.99.1]
synonym: "glutamic acid mutase activity" EXACT [EC:5.4.99.1]
synonym: "glutamic isomerase activity" EXACT [EC:5.4.99.1]
synonym: "glutamic mutase activity" EXACT [EC:5.4.99.1]
synonym: "L-threo-3-methylaspartate carboxy-aminomethylmutase activity" EXACT [EC:5.4.99.1]
synonym: "methylaspartic acid mutase activity" EXACT [EC:5.4.99.1]
xref: EC:5.4.99.1
xref: KEGG:R00262
xref: MetaCyc:METHYLASPARTATE-MUTASE-RXN
xref: RHEA:12860
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0050098
name: methylguanidinase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + methylguanidine = methylammonium + urea." [EC:3.5.3.16, RHEA:11767]
synonym: "methylguanidine amidinohydrolase activity" EXACT [EC:3.5.3.16]
synonym: "methylguanidine hydrolase activity" EXACT [EC:3.5.3.16]
xref: EC:3.5.3.16
xref: KEGG:R01589
xref: MetaCyc:METHYLGUANIDINASE-RXN
xref: RHEA:11767
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0050099
name: methylglutamate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-methyl-L-glutamate + A + H(2)O = L-glutamate + AH(2) + formaldehyde." [EC:1.5.99.5, RHEA:22575]
synonym: "N-methyl-L-glutamate:(acceptor) oxidoreductase (demethylating)" EXACT [EC:1.5.99.5]
synonym: "N-methyl-L-glutamate:acceptor oxidoreductase (demethylating)" EXACT [EC:1.5.99.5]
synonym: "N-methylglutamate dehydrogenase activity" EXACT [EC:1.5.99.5]
xref: EC:1.5.99.5
xref: KEGG:R00609
xref: MetaCyc:METHYLGUTAMATE-DEHYDROGENASE-RXN
xref: RHEA:22575
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0050100
name: methylitaconate delta-isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-methylene-3-methylsuccinate = dimethylmaleate." [EC:5.3.3.6, RHEA:23483]
synonym: "methylitaconate D-isomerase activity" EXACT []
synonym: "methylitaconate delta2-delta3-isomerase activity" EXACT [EC:5.3.3.6]
synonym: "methylitaconate isomerase activity" EXACT [EC:5.3.3.6]
xref: EC:5.3.3.6
xref: KEGG:R03070
xref: MetaCyc:METHYLITACONATE-DELTA-ISOMERASE-RXN
xref: RHEA:23483
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0050101
name: mimosinase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-mimosine + H(2)O = 3-hydroxy-4H-pyrid-4-one + L-serine." [EC:3.5.1.61, RHEA:13376]
synonym: "mimosine amidohydrolase activity" EXACT [EC:3.5.1.61]
xref: EC:3.5.1.61
xref: KEGG:R04350
xref: MetaCyc:MIMOSINASE-RXN
xref: RHEA:13376
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050102
name: cellodextrin phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,4-beta-D-glucosyl(n) + phosphate = 1,4-beta-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate." [EC:2.4.1.49, MetaCyc:CELLODEXTRIN-PHOSPHORYLASE-RXN]
subset: gosubset_prok
synonym: "1,4-beta-D-oligo-D-glucan:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.49]
synonym: "beta-1,4-oligoglucan:orthophosphate glucosyltransferase activity" EXACT [EC:2.4.1.49]
xref: EC:2.4.1.49
xref: MetaCyc:CELLODEXTRIN-PHOSPHORYLASE-RXN
is_a: GO:0004645 ! phosphorylase activity

[Term]
id: GO:0050103
name: dextrin dextranase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + 1,6-alpha-D-glucosyl(m) = 1,4-alpha-D-glucosyl(n-1) + 1,6-alpha-D-glucosyl(m+1)." [EC:2.4.1.2, MetaCyc:DEXTRIN-DEXTRANASE-RXN]
synonym: "1,4-alpha-D-glucan:1,6-alpha-D-glucan 6-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.2]
synonym: "dextran dextrinase activity" EXACT [EC:2.4.1.2]
synonym: "dextrin 6-glucosyltransferase activity" EXACT [EC:2.4.1.2]
xref: EC:2.4.1.2
xref: MetaCyc:DEXTRIN-DEXTRANASE-RXN
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0050104
name: L-gulonate 3-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-gulonate + NAD(+) = 3-dehydro-L-gulonate + H(+) + NADH." [EC:1.1.1.45, RHEA:12892]
subset: gosubset_prok
synonym: "L-3-aldonate dehydrogenase activity" EXACT [EC:1.1.1.45]
synonym: "L-3-aldonic dehydrogenase activity" EXACT [EC:1.1.1.45]
synonym: "L-3-hydroxyacid dehydrogenase activity" EXACT [EC:1.1.1.45]
synonym: "L-beta-hydroxy-acid-NAD-oxidoreductase activity" EXACT [EC:1.1.1.45]
synonym: "L-beta-hydroxyacid dehydrogenase activity" EXACT [EC:1.1.1.45]
synonym: "L-gulonate:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.45]
synonym: "L-gulonic acid dehydrogenase activity" EXACT [EC:1.1.1.45]
xref: EC:1.1.1.45
xref: KEGG:R02640
xref: MetaCyc:L-GULONATE-3-DEHYDROGENASE-RXN
xref: RHEA:12892
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050105
name: L-gulonolactone oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-gulono-1,4-lactone + O2 = L-xylo-hex-3-ulonolactone + H2O2." [EC:1.1.3.8, MetaCyc:L-GULONOLACTONE-OXIDASE-RXN]
subset: gosubset_prok
synonym: "GLO activity" EXACT [EC:1.1.3.8]
synonym: "L-gulono-1,4-lactone:oxygen 3-oxidoreductase activity" EXACT [EC:1.1.3.8]
synonym: "L-gulono-gamma-lactone oxidase activity" EXACT [EC:1.1.3.8]
synonym: "L-gulono-gamma-lactone:O2 oxidoreductase activity" EXACT [EC:1.1.3.8]
synonym: "L-gulono-gamma-lactone:oxidoreductase activity" EXACT [EC:1.1.3.8]
xref: EC:1.1.3.8
xref: MetaCyc:L-GULONOLACTONE-OXIDASE-RXN
xref: RHEA:25083
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0050106
name: monomethyl-sulfatase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + monomethyl sulfate = H(+) + methanol + sulfate." [EC:3.1.6.16, RHEA:14224]
synonym: "monomethyl-sulfate sulfohydrolase activity" EXACT [EC:3.1.6.16]
synonym: "monomethyl-sulphatase activity" EXACT []
xref: EC:3.1.6.16
xref: KEGG:R01145
xref: MetaCyc:MONOMETHYL-SULFATASE-RXN
xref: RHEA:14224
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0050107
name: monoterpenol O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + a monoterpenol = CoA + a monoterpenol acetate ester." [EC:2.3.1.69, MetaCyc:MONOTERPENOL-O-ACETYLTRANSFERASE-RXN]
synonym: "acetyl-CoA:monoterpenol O-acetyltransferase activity" EXACT [EC:2.3.1.69]
synonym: "menthol transacetylase activity" NARROW [EC:2.3.1.69]
xref: EC:2.3.1.69
xref: MetaCyc:MONOTERPENOL-O-ACETYLTRANSFERASE-RXN
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0050108
name: monoterpenyl-diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: monoterpenyl diphosphate + H2O = monoterpenol + diphosphate." [EC:3.1.7.3, MetaCyc:MONOTERPENYL-PYROPHOSPHATASE-RXN]
synonym: "bornyl diphosphate hydrolase activity" EXACT [EC:3.1.7.3]
synonym: "bornyl pyrophosphate hydrolase activity" EXACT [EC:3.1.7.3]
synonym: "monoterpenyl-diphosphate diphosphohydrolase activity" EXACT [EC:3.1.7.3]
synonym: "monoterpenyl-pyrophosphatase activity" EXACT []
xref: EC:3.1.7.3
xref: MetaCyc:MONOTERPENYL-PYROPHOSPHATASE-RXN
is_a: GO:0016794 ! diphosphoric monoester hydrolase activity

[Term]
id: GO:0050109
name: morphine 6-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: morphine + NAD(P)+ = morphinone + NAD(P)H + H+." [EC:1.1.1.218, MetaCyc:MORPHINE-6-DEHYDROGENASE-RXN]
subset: gosubset_prok
synonym: "morphine:NAD(P)+ 6-oxidoreductase activity" EXACT [EC:1.1.1.218]
synonym: "naloxone reductase activity" EXACT [EC:1.1.1.218]
synonym: "reductase, naloxone" EXACT [EC:1.1.1.218]
xref: EC:1.1.1.218
xref: MetaCyc:MORPHINE-6-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050110
name: mucinaminylserine mucinaminidase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-galactosyl-3-(N-acetyl-beta-D-galactosaminyl)-L-serine + H2O = D-galactosyl-3-N-acetyl-beta-D-galactosamine + L-serine." [MetaCyc:3.2.1.110-RXN]
synonym: "D-galactosyl-3-(N-acetyl-beta-D-galactosaminyl)-L-serine mucinaminohydrolase activity" EXACT [EC:3.2.1.110]
synonym: "endo-beta-N-acetyl-D-galactosaminidase activity" BROAD [EC:3.2.1.110]
synonym: "endo-beta-N-acetylgalactosaminidase" BROAD [EC:3.2.1.110]
xref: EC:3.2.1.97
xref: KEGG:R04527
xref: MetaCyc:3.2.1.110-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0050111
name: mycocerosate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + 7n H(+) + n methylmalonyl-CoA + 2n NADPH = n CO(2) + n CoA + n H(2)O + multi-methyl-branched acyl-CoA + 2n NADP(+)." [EC:2.3.1.111, RHEA:10591]
synonym: "acyl-CoA:methylmalonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing)" EXACT [EC:2.3.1.111]
synonym: "mycocerosic acid synthase activity" EXACT [EC:2.3.1.111]
xref: EC:2.3.1.111
xref: KEGG:R05189
xref: MetaCyc:MYCOCEROSATE-SYNTHASE-RXN
xref: RHEA:10591
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0050112
name: inositol 2-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: myo-inositol + NAD(+) = 2,4,6/3,5-pentahydroxycyclohexanone + H(+) + NADH." [EC:1.1.1.18, RHEA:16952]
subset: gosubset_prok
synonym: "inositol:NAD 2-dehydrogenase activity" EXACT []
synonym: "myo-inositol 2-dehydrogenase activity" EXACT []
xref: EC:1.1.1.18
xref: KEGG:R01183
xref: MetaCyc:MYO-INOSITOL-2-DEHYDROGENASE-RXN
xref: RHEA:16952
is_a: GO:0004022 ! alcohol dehydrogenase (NAD) activity

[Term]
id: GO:0050113
name: inositol oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: myo-inositol + O(2) = D-glucuronate + H(2)O + H(+)." [EC:1.13.99.1, RHEA:23699]
synonym: "meso-inositol oxygenase activity" EXACT [EC:1.13.99.1]
synonym: "MOO activity" EXACT [EC:1.13.99.1]
synonym: "myo-inositol oxygenase activity" EXACT []
synonym: "myo-inositol:oxygen oxidoreductase activity" EXACT [EC:1.13.99.1]
xref: EC:1.13.99.1
xref: KEGG:R01184
xref: MetaCyc:MYO-INOSITOL-OXYGENASE-RXN
xref: RHEA:23699
is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen

[Term]
id: GO:0050114
name: myo-inosose-2 dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4,6/3,5-pentahydroxycyclohexanone = 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H(2)O." [EC:4.2.1.44, RHEA:14068]
synonym: "2,4,6/3,5-pentahydroxycyclohexanone hydro-lyase (3,5/4-trihydroxycyclohexa-1,2-dione-forming)" EXACT [EC:4.2.1.44]
synonym: "2,4,6/3,5-pentahydroxycyclohexanone hydro-lyase activity" EXACT [EC:4.2.1.44]
synonym: "inosose 2,3-dehydratase activity" EXACT [EC:4.2.1.44]
synonym: "ketoinositol dehydratase activity" EXACT [EC:4.2.1.44]
xref: EC:4.2.1.44
xref: KEGG:R02782
xref: MetaCyc:MYO-INOSOSE-2-DEHYDRATASE-RXN
xref: RHEA:14068
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050115
name: myosin-light-chain-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: myosin light-chain phosphate + H2O = myosin light chain + phosphate." [EC:3.1.3.53, MetaCyc:MYOSIN-LIGHT-CHAIN-PHOSPHATASE-RXN]
synonym: "[Myosin light-chain]-phosphatase activity" EXACT []
synonym: "myosin light chain kinase phosphatase activity" EXACT [EC:3.1.3.53]
synonym: "myosin light-chain kinase phosphatase activity" RELATED [EC:3.1.3.53]
synonym: "myosin-light-chain phosphatase activity" EXACT [EC:3.1.3.53]
synonym: "myosin-light-chain-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.53]
synonym: "protein phosphatase 2A" RELATED [EC:3.1.3.53]
xref: EC:3.1.3.53
xref: MetaCyc:MYOSIN-LIGHT-CHAIN-PHOSPHATASE-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0050116
name: N,N-dimethylformamidase activity
namespace: molecular_function
def: "Catalysis of the reaction: N,N-dimethylformamide + H(2)O = dimethylamine + formate." [EC:3.5.1.56, RHEA:19520]
synonym: "dimethylformamidase activity" EXACT [EC:3.5.1.56]
synonym: "DMFase activity" EXACT [EC:3.5.1.56]
synonym: "N,N-dimethylformamide amidohydrolase activity" EXACT [EC:3.5.1.56]
xref: EC:3.5.1.56
xref: KEGG:R02509
xref: MetaCyc:NN-DIMETHYLFORMAMIDASE-RXN
xref: RHEA:19520
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050117
name: N-acetyl-beta-alanine deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-beta-alanine + H(2)O = beta-alanine + acetate." [EC:3.5.1.21, RHEA:23215]
synonym: "N-acetyl-beta-alanine amidohydrolase activity" EXACT [EC:3.5.1.21]
xref: EC:3.5.1.21
xref: KEGG:R00909
xref: MetaCyc:N-ACETYL-BETA-ALANINE-DEACETYLASE-RXN
xref: RHEA:23215
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0019213 ! deacetylase activity

[Term]
id: GO:0050118
name: N-acetyldiaminopimelate deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-LL-2,6-diaminopimelate + H(2)O = LL-2,6-diaminopimelate + acetate." [EC:3.5.1.47, RHEA:20408]
subset: gosubset_prok
synonym: "6-N-acetyl-LL-2,6-diaminoheptanedioate amidohydrolase activity" EXACT [EC:3.5.1.47]
synonym: "N-acetyl-L-diaminopimelic acid deacylase activity" EXACT [EC:3.5.1.47]
synonym: "N-acetyl-LL-diaminopimelate deacylase activity" EXACT [EC:3.5.1.47]
synonym: "N6-acetyl-LL-2,6-diaminoheptanedioate amidohydrolase activity" EXACT [EC:3.5.1.47]
xref: EC:3.5.1.47
xref: KEGG:R02733
xref: MetaCyc:N-ACETYLDIAMINOPIMELATE-DEACETYLASE-RXN
xref: RHEA:20408
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0019213 ! deacetylase activity

[Term]
id: GO:0050119
name: N-acetylglucosamine deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-D-glucosamine + H(2)O = D-glucosamine + acetate." [EC:3.5.1.33, RHEA:20596]
synonym: "acetylaminodeoxyglucose acetylhydrolase activity" EXACT [EC:3.5.1.33]
synonym: "N-acetyl-D-glucosamine amidohydrolase activity" EXACT [EC:3.5.1.33]
synonym: "N-acetyl-D-glucosaminyl N-deacetylase activity" EXACT [EC:3.5.1.33]
xref: EC:3.5.1.33
xref: KEGG:R01200
xref: MetaCyc:N-ACETYLGLUCOSAMINE-DEACETYLASE-RXN
xref: RHEA:20596
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0019213 ! deacetylase activity

[Term]
id: GO:0050120
name: N-acetylhexosamine 1-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-D-glucosamine + H(2)O + NAD(+) = N-acetyl-D-glucosaminate + 2 H(+) + NADH." [EC:1.1.1.240, RHEA:23147]
synonym: "N-acetyl-D-hexosamine dehydrogenase activity" EXACT [EC:1.1.1.240]
synonym: "N-acetyl-D-hexosamine:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.240]
synonym: "N-acetylhexosamine dehydrogenase activity" EXACT [EC:1.1.1.240]
xref: EC:1.1.1.240
xref: KEGG:R01202
xref: MetaCyc:N-ACETYLHEXOSAMINE-1-DEHYDROGENASE-RXN
xref: RHEA:23147
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050121
name: N-acylglucosamine 2-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acyl-D-glucosamine = N-acyl-D-mannosamine." [EC:5.1.3.8, MetaCyc:N-ACYLGLUCOSAMINE-2-EPIMERASE-RXN]
subset: gosubset_prok
synonym: "acylglucosamine 2-epimerase activity" EXACT [EC:5.1.3.8]
synonym: "GlcNAc 2-epimerase activity" EXACT [EC:5.1.3.8]
synonym: "N-acetyl-D-glucosamine 2-epimerase activity" EXACT [EC:5.1.3.8]
synonym: "N-acetylglucosamine 2-epimerase activity" EXACT [EC:5.1.3.8]
synonym: "N-acyl-D-glucosamine 2-epimerase activity" EXACT [EC:5.1.3.8]
xref: EC:5.1.3.8
xref: MetaCyc:N-ACYLGLUCOSAMINE-2-EPIMERASE-RXN
xref: RHEA:19036
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0050122
name: N-acylhexosamine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-D-glucosamine + H(2)O + O(2) = N-acetyl-D-glucosaminate + H(2)O(2) + H(+)." [EC:1.1.3.29, RHEA:13032]
synonym: "N-acyl-beta-D-hexosamine:oxygen 1-oxidoreductase activity" EXACT [EC:1.1.3.29]
synonym: "N-acyl-D-hexosamine oxidase activity" EXACT [EC:1.1.3.29]
synonym: "N-acyl-D-hexosamine:oxygen 1-oxidoreductase activity" EXACT [EC:1.1.3.29]
xref: EC:1.1.3.29
xref: KEGG:R01203
xref: MetaCyc:N-ACYLHEXOSAMINE-OXIDASE-RXN
xref: RHEA:13032
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0050123
name: N-acylmannosamine 1-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acyl-D-mannosamine + NAD(+) = N-acyl-D-mannosaminolactone + H(+) + NADH." [EC:1.1.1.233, RHEA:11543]
subset: gosubset_prok
synonym: "N-acetyl-D-mannosamine dehydrogenase activity" EXACT [EC:1.1.1.233]
synonym: "N-acyl-D-mannosamine dehydrogenase activity" EXACT [EC:1.1.1.233]
synonym: "N-acyl-D-mannosamine:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.233]
synonym: "N-acylmannosamine dehydrogenase activity" EXACT [EC:1.1.1.233]
xref: EC:1.1.1.233
xref: KEGG:R02651
xref: MetaCyc:N-ACYLMANNOSAMINE-1-DEHYDROGENASE-RXN
xref: RHEA:11543
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050124
name: N-acylneuraminate-9-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acylneuraminate 9-phosphate + H2O = N-acylneuraminate + phosphate." [EC:3.1.3.29, MetaCyc:N-ACYLNEURAMINATE-9-PHOSPHATASE-RXN]
subset: gosubset_prok
synonym: "acylneuraminate 9-phosphatase activity" EXACT [EC:3.1.3.29]
synonym: "N-acylneuraminate-9-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.29]
synonym: "N-acylneuraminic (sialic) acid 9-phosphatase activity" EXACT [EC:3.1.3.29]
synonym: "N-acylneuraminic acid 9-phosphate phosphatase activity" EXACT [EC:3.1.3.29]
xref: EC:3.1.3.29
xref: MetaCyc:N-ACYLNEURAMINATE-9-PHOSPHATASE-RXN
xref: RHEA:13060
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0050125
name: N-benzyloxycarbonylglycine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-benzyloxycarbonylglycine + H(2)O + H(+) = benzyl alcohol + CO(2) + glycine." [EC:3.5.1.58, RHEA:20903]
synonym: "benzyloxycarbonylglycine hydrolase activity" EXACT [EC:3.5.1.58]
synonym: "N-benzyloxycarbonylglycine urethanehydrolase activity" EXACT [EC:3.5.1.58]
synonym: "nalpha-benzyloxycarbonyl amino acid urethane hydrolase activity" EXACT [EC:3.5.1.58]
synonym: "nalpha-benzyloxycarbonyl amino acid urethane hydrolase I" RELATED [EC:3.5.1.58]
synonym: "nalpha-carbobenzoxyamino acid amidohydrolase activity" EXACT [EC:3.5.1.58]
xref: EC:3.5.1.58
xref: KEGG:R02551
xref: MetaCyc:N-BENZYLOXYCARBONYLGLYCINE-HYDROLASE-RXN
xref: RHEA:20903
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050126
name: N-carbamoylputrescine amidase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-carbamoylputrescine + H(2)O + 2 H(+) = CO(2) + NH(4)(+) + putrescine." [EC:3.5.1.53, RHEA:22287]
synonym: "carbamoylputrescine hydrolase activity" EXACT [EC:3.5.1.53]
synonym: "N-carbamoylputrescine amidohydrolase activity" EXACT [EC:3.5.1.53]
synonym: "NCP" RELATED [EC:3.5.1.53]
xref: EC:3.5.1.53
xref: KEGG:R01152
xref: MetaCyc:N-CARBAMOYLPUTRESCINE-AMIDASE-RXN
xref: RHEA:22287
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050127
name: N-carbamoylsarcosine amidase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-carbamoylsarcosine + H(2)O + 2 H(+) = CO(2) + NH(4)(+) + sarcosine." [EC:3.5.1.59, RHEA:20060]
subset: gosubset_prok
synonym: "carbamoylsarcosine amidase activity" EXACT [EC:3.5.1.59]
synonym: "CSHase activity" EXACT [EC:3.5.1.59]
synonym: "N-carbamoylsarcosine amidohydrolase activity" EXACT [EC:3.5.1.59]
xref: EC:3.5.1.59
xref: KEGG:R01563
xref: MetaCyc:N-CARBAMOYLSARCOSINE-AMIDASE-RXN
xref: RHEA:20060
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050128
name: N-feruloylglycine deacylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-feruloylglycine + H(2)O = ferulate + glycine." [EC:3.5.1.71, RHEA:10487]
synonym: "N-feruloylglycine amidohydrolase activity" EXACT [EC:3.5.1.71]
synonym: "N-feruloylglycine hydrolase activity" EXACT [EC:3.5.1.71]
xref: EC:3.5.1.71
xref: KEGG:R03579
xref: MetaCyc:N-FERULOYLGLYCINE-DEACYLASE-RXN
xref: RHEA:10487
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050129
name: N-formylglutamate deformylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-formyl-L-glutamate + H(2)O = L-glutamate + formate." [EC:3.5.1.68, RHEA:12479]
subset: gosubset_prok
synonym: "beta-citryl-L-glutamate amidase activity" EXACT [EC:3.5.1.68]
synonym: "beta-citryl-L-glutamate amidohydrolase activity" EXACT [EC:3.5.1.68]
synonym: "beta-citryl-L-glutamate hydrolase activity" EXACT [EC:3.5.1.68]
synonym: "beta-citryl-L-glutamate-hydrolyzing enzyme" RELATED [EC:3.5.1.68]
synonym: "beta-citrylglutamate amidase activity" EXACT [EC:3.5.1.68]
synonym: "formylglutamate deformylase activity" EXACT [EC:3.5.1.68]
synonym: "N-formyl-L-glutamate amidohydrolase activity" EXACT [EC:3.5.1.68]
synonym: "N-formylglutamate hydrolase activity" EXACT [EC:3.5.1.68]
xref: EC:3.5.1.68
xref: KEGG:R00525
xref: MetaCyc:N-FORMYLGLUTAMATE-DEFORMYLASE-RXN
xref: RHEA:12479
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050130
name: N-methyl-2-oxoglutaramate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-methyl-2-oxoglutaramate + H(2)O = 2-oxoglutarate + methylammonium." [EC:3.5.1.36, RHEA:24111]
synonym: "5-hydroxy-N-methylpyroglutamate synthase activity" EXACT [EC:3.5.1.36]
synonym: "N-methyl-2-oxoglutaramate methylamidohydrolase activity" EXACT [EC:3.5.1.36]
xref: EC:3.5.1.36
xref: KEGG:R01587
xref: MetaCyc:N-METHYL-2-OXOGLUTARAMATE-HYDROLASE-RXN
xref: RHEA:24111
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050131
name: N-methyl-L-amino-acid oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: an N-methyl-L-amino acid + H2O + O2 = an L-amino acid + formaldehyde + H2O2." [EC:1.5.3.2, MetaCyc:N-METHYL-L-AMINO-ACID-OXIDASE-RXN]
synonym: "N-methyl-L-amino-acid:oxygen oxidoreductase (demethylating)" EXACT [EC:1.5.3.2]
synonym: "N-methylamino acid oxidase activity" EXACT [EC:1.5.3.2]
xref: EC:1.5.3.2
xref: MetaCyc:N-METHYL-L-AMINO-ACID-OXIDASE-RXN
is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor

[Term]
id: GO:0050132
name: N-methylalanine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-methyl-L-alanine + H(2)O + NADP(+) = H(+) + methylammonium + NADPH + pyruvate." [EC:1.4.1.17, RHEA:21771]
synonym: "N-methyl-L-alanine:NADP+ oxidoreductase (demethylating, deaminating)" EXACT [EC:1.4.1.17]
xref: EC:1.4.1.17
xref: KEGG:R01584
xref: MetaCyc:N-METHYLALANINE-DEHYDROGENASE-RXN
xref: RHEA:21771
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050133
name: N6-hydroxylysine O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N(6)-hydroxy-L-lysine + acetyl-CoA = N(6)-acetyl-N(6)-hydroxy-L-lysine + CoA." [EC:2.3.1.102, RHEA:22391]
synonym: "acetyl-CoA:6-N-hydroxy-L-lysine 6-acetyltransferase activity" EXACT [EC:2.3.1.102]
synonym: "acetyl-CoA:N6-hydroxy-L-lysine 6-acetyltransferase activity" EXACT [EC:2.3.1.102]
synonym: "N(6)-hydroxylysine acetylase activity" EXACT [EC:2.3.1.102]
synonym: "N6-hydroxylysine acetylase activity" EXACT [EC:2.3.1.102]
synonym: "N6-hydroxylysine:acetyl CoA N6-transacetylase activity" EXACT [EC:2.3.1.102]
xref: EC:2.3.1.102
xref: KEGG:R03168
xref: MetaCyc:N6-HYDROXYLYSINE-O-ACETYLTRANSFERASE-RXN
xref: RHEA:22391
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0050134
name: N6-methyl-lysine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: N(6)-methyl-L-lysine + H(2)O + O(2) = L-lysine + formaldehyde + H(2)O(2)." [EC:1.5.3.4, RHEA:23203]
synonym: "6-N-methyl-L-lysine:oxygen oxidoreductase (demethylating)" EXACT [EC:1.5.3.4]
synonym: "epsilon-alkyl-L-lysine:oxygen oxidoreductase activity" EXACT [EC:1.5.3.4]
synonym: "epsilon-alkyllysinase activity" EXACT [EC:1.5.3.4]
synonym: "epsilon-N-methyllysine demethylase activity" EXACT [EC:1.5.3.4]
synonym: "N(6)-methyllysine oxidase activity" EXACT [EC:1.5.3.4]
synonym: "N6-methyl-L-lysine:oxygen oxidoreductase (demethylating)" EXACT [EC:1.5.3.4]
synonym: "N6-methyllysine oxidase activity" EXACT [EC:1.5.3.4]
xref: EC:1.5.3.4
xref: KEGG:R00612
xref: MetaCyc:N6-METHYL-LYSINE-OXIDASE-RXN
xref: RHEA:23203
is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor

[Term]
id: GO:0050135
name: NAD(P)+ nucleosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(P)+ + H2O = ADP-ribose(P) + nicotinamide." [EC:3.2.2.6, MetaCyc:NADP+-NUCLEOSIDASE-RXN]
synonym: "NAD(P) nucleosidase activity" EXACT []
synonym: "NAD(P)(+) nucleosidase activity" EXACT []
synonym: "NAD(P)+ glycohydrolase activity" EXACT [EC:3.2.2.6]
synonym: "NAD(P)ase activity" EXACT [EC:3.2.2.6]
synonym: "nicotinamide adenine dinucleotide (phosphate) glycohydrolase activity" EXACT [EC:3.2.2.6]
synonym: "nicotinamide adenine dinucleotide (phosphate) nucleosidase activity" EXACT [EC:3.2.2.6]
synonym: "triphosphopyridine nucleotidase activity" EXACT [EC:3.2.2.6]
xref: EC:3.2.2.6
xref: MetaCyc:NADP+-NUCLEOSIDASE-RXN
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0050136
name: NADH dehydrogenase (quinone) activity
namespace: molecular_function
def: "Catalysis of the reaction: NADH + H+ + a quinone = NAD+ + a quinol." [EC:1.6.99.5, GOC:mah, MetaCyc:NADH-DEHYDROGENASE-QUINONE-RXN]
subset: gosubset_prok
synonym: "D-diaphorase activity" EXACT [EC:1.6.99.5]
synonym: "DPNH-menadione reductase activity" EXACT [EC:1.6.99.5]
synonym: "NADH-quinone oxidoreductase activity" EXACT [EC:1.6.99.5]
synonym: "NADH:(quinone-acceptor) oxidoreductase activity" EXACT [EC:1.6.99.5]
synonym: "reduced nicotinamide adenine dinucleotide (quinone) dehydrogenase activity" EXACT [EC:1.6.99.5]
xref: EC:1.6.99.5
xref: MetaCyc:NADH-DEHYDROGENASE-QUINONE-RXN
is_a: GO:0003954 ! NADH dehydrogenase activity
is_a: GO:0016655 ! oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor

[Term]
id: GO:0050137
name: NADPH peroxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O(2) + H(+) + NADPH = 2 H(2)O + NADP(+)." [EC:1.11.1.2, RHEA:15176]
synonym: "NADP peroxidase activity" EXACT [EC:1.11.1.2]
synonym: "NADPH:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.2]
synonym: "nicotinamide adenine dinucleotide phosphate peroxidase activity" EXACT [EC:1.11.1.2]
synonym: "TPN peroxidase activity" EXACT [EC:1.11.1.2]
synonym: "TPNH peroxidase activity" EXACT [EC:1.11.1.2]
synonym: "triphosphopyridine nucleotide peroxidase activity" EXACT [EC:1.11.1.2]
xref: EC:1.11.1.2
xref: KEGG:R00113
xref: MetaCyc:NADPH-PEROXIDASE-RXN
xref: RHEA:15176
is_a: GO:0004601 ! peroxidase activity

[Term]
id: GO:0050138
name: nicotinate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + NADP(+) + nicotinate = 6-hydroxynicotinate + H(+) + NADPH." [EC:1.17.1.5, RHEA:12239]
synonym: "nicotinate hydroxylase activity" EXACT [EC:1.17.1.5]
synonym: "nicotinate:NADP+ 6-oxidoreductase (hydroxylating)" EXACT [EC:1.17.1.5]
synonym: "nicotinic acid hydroxylase activity" EXACT [EC:1.17.1.5]
xref: EC:1.17.1.5
xref: KEGG:R01720
xref: MetaCyc:NICOTINATE-DEHYDROGENASE-RXN
xref: MetaCyc:RXN-7637
xref: RHEA:12239
is_a: GO:0016726 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor

[Term]
id: GO:0050139
name: nicotinate glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: nicotinate + UDP-D-glucose = N-(beta-D-glucosyl)nicotinate + UDP." [EC:2.4.1.196, RHEA:19440]
synonym: "UDP-glucose:nicotinate N-glucosyltransferase activity" EXACT [EC:2.4.1.196]
synonym: "UDP-glucose:nicotinic acid-N-glucosyltransferase activity" EXACT [EC:2.4.1.196]
synonym: "UDPglucose:nicotinate N-glucosyltransferase activity" EXACT [EC:2.4.1.196]
synonym: "uridine diphosphoglucose-nicotinate N-glucosyltransferase activity" EXACT [EC:2.4.1.196]
xref: EC:2.4.1.196
xref: KEGG:R01722
xref: MetaCyc:NICOTINATE-GLUCOSYLTRANSFERASE-RXN
xref: RHEA:19440
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0050140
name: nitrate reductase (cytochrome) activity
namespace: molecular_function
def: "Catalysis of the reaction: ferrocytochrome + nitrate = ferricytochrome + nitrite." [EC:1.9.6.1, MetaCyc:NITRATE-REDUCTASE-CYTOCHROME-RXN]
synonym: "benzyl viologen-nitrate reductase activity" EXACT [EC:1.9.6.1]
synonym: "ferrocytochrome:nitrate oxidoreductase activity" EXACT [EC:1.9.6.1]
xref: EC:1.9.6.1
xref: MetaCyc:NITRATE-REDUCTASE-CYTOCHROME-RXN
is_a: GO:0016677 ! oxidoreductase activity, acting on a heme group of donors, nitrogenous group as acceptor

[Term]
id: GO:0050141
name: nitroethane oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: nitroethane + H2O + O2 = acetaldehyde + nitrite + H2O2." [EC:1.7.3.1, MetaCyc:NITROETHANE-OXIDASE-RXN]
synonym: "nitroethane reductase activity" EXACT [EC:1.7.3.1]
synonym: "nitroethane:oxygen oxidoreductase activity" EXACT [EC:1.7.3.1]
xref: EC:1.7.3.1
xref: MetaCyc:NITROETHANE-OXIDASE-RXN
is_a: GO:0052664 ! nitroalkane oxidase activity

[Term]
id: GO:0050142
name: nitrogenase (flavodoxin) activity
namespace: molecular_function
def: "Catalysis of the reaction: 6 reduced flavodoxin + 6 H+ + N2 + n ATP = 6 oxidized flavodoxin + 2 NH3 + n ADP + n phosphate." [EC:1.19.6.1, MetaCyc:NITROGENASE-FLAVODOXIN-RXN]
subset: gosubset_prok
synonym: "reduced flavodoxin:dinitrogen oxidoreductase (ATP-hydrolysing)" EXACT [EC:1.19.6.1]
xref: EC:1.19.6.1
xref: MetaCyc:NITROGENASE-FLAVODOXIN-RXN
is_a: GO:0016738 ! oxidoreductase activity, acting on reduced flavodoxin as donor, dinitrogen as acceptor

[Term]
id: GO:0050143
name: nocardicin-A epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: isonocardicin A = nocardicin A." [EC:5.1.1.14, RHEA:22795]
synonym: "isonocardicin A epimerase activity" EXACT [EC:5.1.1.14]
xref: EC:5.1.1.14
xref: KEGG:R03073
xref: MetaCyc:NOCARDICIN-A-EPIMERASE-RXN
xref: RHEA:22795
is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives

[Term]
id: GO:0050144
name: nucleoside deoxyribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-deoxy-D-ribosyl-base1 + base2 = 2-deoxy-D-ribosyl-base2 + base1." [EC:2.4.2.6, MetaCyc:NUCLEOSIDE-DEOXYRIBOSYLTRANSFERASE-RXN]
subset: gosubset_prok
synonym: "deoxyribose transferase activity" EXACT [EC:2.4.2.6]
synonym: "nucleoside deoxyribosyltransferase I (purine nucleoside:purine deoxyribosyltransferase: strictly specific for transfer between purine bases)" RELATED [EC:2.4.2.6]
synonym: "nucleoside deoxyribosyltransferase II [purine(pyrimidine) nucleoside:purine(pyrimidine) deoxyribosyltransferase]" RELATED [EC:2.4.2.6]
synonym: "nucleoside trans-N-deoxyribosylase activity" EXACT [EC:2.4.2.6]
synonym: "nucleoside:purine(pyrimidine) deoxy-D-ribosyltransferase activity" EXACT [EC:2.4.2.6]
synonym: "purine(pyrimidine) nucleoside:purine(pyrimidine) deoxyribosyl transferase activity" EXACT [EC:2.4.2.6]
synonym: "trans-deoxyribosylase activity" EXACT [EC:2.4.2.6]
synonym: "trans-N-deoxyribosylase activity" EXACT [EC:2.4.2.6]
synonym: "trans-N-glycosidase activity" EXACT [EC:2.4.2.6]
xref: EC:2.4.2.6
xref: MetaCyc:NUCLEOSIDE-DEOXYRIBOSYLTRANSFERASE-RXN
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0050145
name: nucleoside phosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + nucleoside phosphate = ADP + nucleoside diphosphate." [EC:2.7.4.4, MetaCyc:NUCLEOSIDE-PHOSPHATE-KINASE-RXN]
synonym: "ATP:nucleoside-phosphate phosphotransferase activity" EXACT [EC:2.7.4.4]
synonym: "NMP-kinase activity" EXACT [EC:2.7.4.4]
synonym: "nucleoside monophosphate kinase activity" EXACT [GOC:dph, GOC:tb]
synonym: "nucleoside-phosphate kinase activity" EXACT []
xref: EC:2.7.4.4
xref: MetaCyc:NUCLEOSIDE-PHOSPHATE-KINASE-RXN
xref: Reactome:REACT_101025 "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP [CMPK1], Schizosaccharomyces pombe"
xref: Reactome:REACT_101237 "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK], Schizosaccharomyces pombe"
xref: Reactome:REACT_102492 "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK], Oryza sativa"
xref: Reactome:REACT_102668 "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP [CMPK1], Arabidopsis thaliana"
xref: Reactome:REACT_102869 "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK], Dictyostelium discoideum"
xref: Reactome:REACT_103092 "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK], Caenorhabditis elegans"
xref: Reactome:REACT_103095 "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK], Danio rerio"
xref: Reactome:REACT_104503 "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK], Canis familiaris"
xref: Reactome:REACT_105781 "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK], Danio rerio"
xref: Reactome:REACT_106187 "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP [CMPK1], Xenopus tropicalis"
xref: Reactome:REACT_106271 "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP [CMPK1], Taeniopygia guttata"
xref: Reactome:REACT_106859 "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK], Taeniopygia guttata"
xref: Reactome:REACT_107155 "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK], Saccharomyces cerevisiae"
xref: Reactome:REACT_107396 "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP [CMPK1], Gallus gallus"
xref: Reactome:REACT_107431 "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP [CMPK1], Dictyostelium discoideum"
xref: Reactome:REACT_110406 "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK], Xenopus tropicalis"
xref: Reactome:REACT_110802 "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP [CMPK1], Schizosaccharomyces pombe"
xref: Reactome:REACT_110894 "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP [CMPK1], Drosophila melanogaster"
xref: Reactome:REACT_112506 "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP [CMPK1], Escherichia coli"
xref: Reactome:REACT_112761 "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP [CMPK1], Escherichia coli"
xref: Reactome:REACT_1618 "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP [CMPK1], Homo sapiens"
xref: Reactome:REACT_247 "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP [CMPK1], Homo sapiens"
xref: Reactome:REACT_273 "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK], Homo sapiens"
xref: Reactome:REACT_28035 "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK], Mus musculus"
xref: Reactome:REACT_28517 "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK], Canis familiaris"
xref: Reactome:REACT_29056 "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP [CMPK1], Bos taurus"
xref: Reactome:REACT_29742 "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP [CMPK1], Arabidopsis thaliana"
xref: Reactome:REACT_30912 "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP [CMPK1], Oryza sativa"
xref: Reactome:REACT_31184 "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK], Taeniopygia guttata"
xref: Reactome:REACT_31211 "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK], Schizosaccharomyces pombe"
xref: Reactome:REACT_31326 "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP [CMPK1], Canis familiaris"
xref: Reactome:REACT_31393 "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP [CMPK1], Danio rerio"
xref: Reactome:REACT_31814 "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP [CMPK1], Saccharomyces cerevisiae"
xref: Reactome:REACT_32116 "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK], Xenopus tropicalis"
xref: Reactome:REACT_33118 "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP [CMPK1], Bos taurus"
xref: Reactome:REACT_33162 "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP [CMPK1], Oryza sativa"
xref: Reactome:REACT_33989 "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP [CMPK1], Sus scrofa"
xref: Reactome:REACT_34334 "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP [CMPK1], Plasmodium falciparum"
xref: Reactome:REACT_47194 "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK], Bos taurus"
xref: Reactome:REACT_58658 "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK], Mus musculus"
xref: Reactome:REACT_636 "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK], Homo sapiens"
xref: Reactome:REACT_77103 "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK], Drosophila melanogaster"
xref: Reactome:REACT_79119 "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK], Saccharomyces cerevisiae"
xref: Reactome:REACT_79556 "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP [CMPK1], Xenopus tropicalis"
xref: Reactome:REACT_80626 "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP [CMPK1], Mus musculus"
xref: Reactome:REACT_80836 "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP [CMPK1], Canis familiaris"
xref: Reactome:REACT_81211 "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP [CMPK1], Saccharomyces cerevisiae"
xref: Reactome:REACT_81450 "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK], Gallus gallus"
xref: Reactome:REACT_81753 "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK], Plasmodium falciparum"
xref: Reactome:REACT_82294 "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP [CMPK1], Dictyostelium discoideum"
xref: Reactome:REACT_83351 "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP [CMPK1], Caenorhabditis elegans"
xref: Reactome:REACT_84720 "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK], Rattus norvegicus"
xref: Reactome:REACT_85301 "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK], Arabidopsis thaliana"
xref: Reactome:REACT_85919 "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK], Bos taurus"
xref: Reactome:REACT_86480 "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK], Rattus norvegicus"
xref: Reactome:REACT_87258 "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP [CMPK1], Gallus gallus"
xref: Reactome:REACT_87777 "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK], Oryza sativa"
xref: Reactome:REACT_87908 "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP [CMPK1], Rattus norvegicus"
xref: Reactome:REACT_87994 "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK], Drosophila melanogaster"
xref: Reactome:REACT_88127 "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK], Caenorhabditis elegans"
xref: Reactome:REACT_88406 "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP [CMPK1], Plasmodium falciparum"
xref: Reactome:REACT_88472 "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK], Dictyostelium discoideum"
xref: Reactome:REACT_89024 "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP [CMPK1], Mus musculus"
xref: Reactome:REACT_90614 "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP [CMPK1], Caenorhabditis elegans"
xref: Reactome:REACT_93429 "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK], Plasmodium falciparum"
xref: Reactome:REACT_93544 "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP [CMPK1], Rattus norvegicus"
xref: Reactome:REACT_93611 "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP [CMPK1], Danio rerio"
xref: Reactome:REACT_93688 "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP [CMPK1], Sus scrofa"
xref: Reactome:REACT_93804 "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK], Gallus gallus"
xref: Reactome:REACT_94414 "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP [CMPK1], Taeniopygia guttata"
xref: Reactome:REACT_95672 "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP [CMPK1], Drosophila melanogaster"
xref: Reactome:REACT_96825 "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK], Arabidopsis thaliana"
xref: RHEA:24039
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor
is_a: GO:0019205 ! nucleobase-containing compound kinase activity
relationship: part_of GO:0046940 ! nucleoside monophosphate phosphorylation

[Term]
id: GO:0050146
name: nucleoside phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a nucleotide + a 2'-deoxynucleoside = a nucleoside + a 2'-deoxynucleoside 5'-monophosphate." [EC:2.7.1.77, MetaCyc:NUCLEOSIDE-PHOSPHOTRANSFERASE-RXN]
synonym: "nonspecific nucleoside phosphotransferase activity" EXACT [EC:2.7.1.77]
synonym: "nucleotide:2'-nucleoside 5'-phosphotransferase activity" EXACT [EC:2.7.1.77]
synonym: "nucleotide:3'-deoxynucleoside 5'-phosphotransferase activity" EXACT [EC:2.7.1.77]
synonym: "nucleotide:nucleoside 5'-phosphotransferase activity" EXACT [EC:2.7.1.77]
xref: EC:2.7.1.77
xref: MetaCyc:NUCLEOSIDE-PHOSPHOTRANSFERASE-RXN
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019205 ! nucleobase-containing compound kinase activity

[Term]
id: GO:0050147
name: nucleoside ribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-ribosyl-base1 + base2 = D-ribosyl-base2 + base1." [EC:2.4.2.5, MetaCyc:NUCLEOSIDE-RIBOSYLTRANSFERASE-RXN]
synonym: "nucleoside N-ribosyltransferase activity" EXACT [EC:2.4.2.5]
synonym: "nucleoside:purine(pyrimidine) D-ribosyltransferase activity" EXACT [EC:2.4.2.5]
xref: EC:2.4.2.5
xref: MetaCyc:NUCLEOSIDE-RIBOSYLTRANSFERASE-RXN
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0050148
name: nucleotide diphosphokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + nucleoside 5'-phosphate = AMP + 5'-phosphonucleoside 3'-diphosphate." [EC:2.7.6.4, MetaCyc:NUCLEOTIDE-PYROPHOSPHOKINASE-RXN]
synonym: "ATP nucleotide 3'-pyrophosphokinase activity" EXACT [EC:2.7.6.4]
synonym: "ATP:nucleoside-5'-phosphate diphosphotransferase activity" EXACT [EC:2.7.6.4]
synonym: "ATP:nucleotide pyrophosphotransferase activity" EXACT [EC:2.7.6.4]
synonym: "nucleotide 3'-pyrophosphokinase activity" EXACT [EC:2.7.6.4]
synonym: "nucleotide pyrophosphokinase activity" EXACT []
xref: EC:2.7.6.4
xref: MetaCyc:NUCLEOTIDE-PYROPHOSPHOKINASE-RXN
is_a: GO:0016778 ! diphosphotransferase activity

[Term]
id: GO:0050149
name: o-aminophenol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 2-aminophenol + 3 O2 = 2 isophenoxazine + 6 H2O." [EC:1.10.3.4, MetaCyc:O-AMINOPHENOL-OXIDASE-RXN]
synonym: "2-aminophenol:O2 oxidoreductase activity" EXACT [EC:1.10.3.4]
synonym: "2-aminophenol:oxygen oxidoreductase activity" EXACT [EC:1.10.3.4]
synonym: "GriF" RELATED [EC:1.10.3.4]
synonym: "isophenoxazine synthase activity" EXACT [EC:1.10.3.4]
synonym: "o-aminophenol:O2 oxidoreductase activity" EXACT [EC:1.10.3.4]
xref: EC:1.10.3.4
xref: MetaCyc:O-AMINOPHENOL-OXIDASE-RXN
is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor

[Term]
id: GO:0050150
name: o-pyrocatechuate decarboxylase activity
namespace: molecular_function
alt_id: GO:0018790
def: "Catalysis of the reaction: 2,3-dihydroxybenzoate + H(+) = catechol + CO(2)." [EC:4.1.1.46, RHEA:21495]
synonym: "2,3-DHBA decarboxylase activity" EXACT [EC:4.1.1.46]
synonym: "2,3-dihydroxybenzoate carboxy-lyase (catechol-forming)" EXACT [EC:4.1.1.46]
synonym: "2,3-dihydroxybenzoate carboxy-lyase activity" EXACT [EC:4.1.1.46]
synonym: "2,3-dihydroxybenzoate decarboxylase activity" EXACT []
synonym: "2,3-dihydroxybenzoic acid decarboxylase activity" EXACT [EC:4.1.1.46]
xref: EC:4.1.1.46
xref: KEGG:R00821
xref: MetaCyc:O-PYROCATECHUATE-DECARBOXYLASE-RXN
xref: RHEA:21495
xref: UM-BBD_reactionID:r0579
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050151
name: oleate hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-10-hydroxystearate = H(2)O + oleate." [EC:4.2.1.53, RHEA:21855]
synonym: "(R)-10-hydroxystearate 10-hydro-lyase (oleate-forming)" EXACT [EC:4.2.1.53]
synonym: "(R)-10-hydroxystearate 10-hydro-lyase activity" EXACT [EC:4.2.1.53]
xref: EC:4.2.1.53
xref: KEGG:R02813
xref: MetaCyc:OLEATE-HYDRATASE-RXN
xref: RHEA:21855
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050152
name: omega-amidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a monoamide of a dicarboxylic acid + H2O = a dicarboxylate + NH3." [EC:3.5.1.3, MetaCyc:OMEGA-AMIDASE-RXN]
synonym: "alpha-keto acid-omega-amidase activity" EXACT [EC:3.5.1.3]
synonym: "omega-amidodicarboxylate amidohydrolase activity" EXACT [EC:3.5.1.3]
synonym: "w-amidase activity" EXACT []
xref: EC:3.5.1.3
xref: MetaCyc:OMEGA-AMIDASE-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050153
name: omega-hydroxydecanoate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 10-hydroxydecanoate + NAD(+) = 10-oxodecanoate + H(+) + NADH." [EC:1.1.1.66, RHEA:20883]
synonym: "10-hydroxydecanoate:NAD+ 10-oxidoreductase activity" EXACT [EC:1.1.1.66]
synonym: "w-hydroxydecanoate dehydrogenase activity" EXACT []
xref: EC:1.1.1.66
xref: KEGG:R03886
xref: MetaCyc:OMEGA-HYDROXYDECANOATE-DEHYDROGENASE-RXN
xref: RHEA:20883
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050154
name: opheline kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + guanidinoethyl methyl phosphate = N'-phosphoguanidinoethyl methylphosphate + ADP + 2 H(+)." [EC:2.7.3.7, RHEA:17556]
synonym: "ATP:guanidinoethyl-methyl-phosphate phosphotransferase activity" EXACT [EC:2.7.3.7]
xref: EC:2.7.3.7
xref: KEGG:R04388
xref: MetaCyc:OPHELINE-KINASE-RXN
xref: RHEA:17556
is_a: GO:0016301 ! kinase activity
is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor

[Term]
id: GO:0050155
name: ornithine(lysine) transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + L-ornithine = H2O + L-glutamate + 3,4-dihydro-2H-pyrrole-2-carboxylate." [EC:2.6.1.68, MetaCyc:ORNITHINELYSINE-AMINOTRANSFERASE-RXN]
synonym: "L-ornithine(L-lysine):2-oxoglutarate-aminotransferase activity" EXACT [EC:2.6.1.68]
synonym: "L-ornithine:2-oxoglutarate-aminotransferase activity" EXACT [EC:2.6.1.68]
synonym: "lysine/ornithine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.68]
synonym: "ornithine(lysine) aminotransferase activity" EXACT []
xref: EC:2.6.1.68
xref: MetaCyc:ORNITHINELYSINE-AMINOTRANSFERASE-RXN
xref: RHEA:23795
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0050156
name: ornithine N-benzoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-ornithine + 2 benzoyl-CoA = N(2),N(5)-dibenzoyl-L-ornithine + 2 CoA + 2 H(+)." [EC:2.3.1.127, RHEA:16932]
synonym: "benzoyl-CoA:L-ornithine N-benzoyltransferase activity" EXACT [EC:2.3.1.127]
synonym: "ornithine N-acyltransferase activity" EXACT [EC:2.3.1.127]
xref: EC:2.3.1.127
xref: KEGG:R00664
xref: MetaCyc:ORNITHINE-N-BENZOYLTRANSFERASE-RXN
xref: RHEA:16932
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0050157
name: ornithine racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-ornithine = D-ornithine." [EC:5.1.1.12, MetaCyc:ORNITHINE-RACEMASE-RXN]
subset: gosubset_prok
xref: EC:5.1.1.12
xref: MetaCyc:ORNITHINE-RACEMASE-RXN
xref: RHEA:11587
is_a: GO:0047661 ! amino-acid racemase activity

[Term]
id: GO:0050158
name: orotate reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-dihydroorotate + NADP(+) = H(+) + NADPH + orotate." [EC:1.3.1.15, RHEA:14864]
synonym: "(S)-dihydroorotate:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.15]
synonym: "dihydro-orotic dehydrogenase activity" EXACT [EC:1.3.1.15]
synonym: "L-5,6-dihydro-orotate:NAD oxidoreductase activity" EXACT [EC:1.3.1.15]
synonym: "orotate reductase activity" EXACT [EC:1.3.1.15]
xref: EC:1.3.1.15
xref: KEGG:R01866
xref: MetaCyc:OROTATE-REDUCTASE-NADPH-RXN
xref: RHEA:14864
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050159
name: orsellinate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: o-orsellinate + H(+) = CO(2) + orcinol." [EC:4.1.1.58, RHEA:16736]
synonym: "orsellinate carboxy-lyase (orcinol-forming)" EXACT [EC:4.1.1.58]
synonym: "orsellinate carboxy-lyase activity" EXACT [EC:4.1.1.58]
xref: EC:4.1.1.58
xref: KEGG:R02831
xref: MetaCyc:ORSELLINATE-DECARBOXYLASE-RXN
xref: RHEA:16736
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050160
name: orsellinate-depside hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + orsellinate depside = 2 o-orsellinate + H(+)." [EC:3.1.1.40, RHEA:19552]
synonym: "lecanorate hydrolase activity" EXACT [EC:3.1.1.40]
xref: EC:3.1.1.40
xref: KEGG:R00054
xref: MetaCyc:ORSELLINATE-DEPSIDE-HYDROLASE-RXN
xref: RHEA:19552
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0050161
name: succinyl-CoA:oxalate CoA-transferase
namespace: molecular_function
def: "Catalysis of the reaction: oxalate + succinyl-CoA = oxalyl-CoA + succinate." [EC:2.8.3.2, RHEA:23591]
synonym: "oxalate CoA-transferase activity" EXACT [EC:2.8.3.2]
synonym: "oxalate coenzyme A-transferase activity" EXACT [EC:2.8.3.2]
synonym: "succinyl-beta-ketoacyl-CoA transferase activity" EXACT [EC:2.8.3.2]
synonym: "succinyl-CoA:oxalate CoA-transferase activity" EXACT [EC:2.8.3.2]
xref: EC:2.8.3.2
xref: KEGG:R01559
xref: MetaCyc:OXALATE-COA-TRANSFERASE-RXN
xref: RHEA:23591
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0050162
name: oxalate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 H(+) + O(2) + oxalate = 2 CO(2) + H(2)O(2)." [EC:1.2.3.4, RHEA:21881]
synonym: "aero-oxalo dehydrogenase activity" EXACT [EC:1.2.3.4]
synonym: "oxalate:oxygen oxidoreductase activity" EXACT [EC:1.2.3.4]
synonym: "oxalic acid oxidase activity" EXACT [EC:1.2.3.4]
xref: EC:1.2.3.4
xref: KEGG:R00273
xref: MetaCyc:OXALATE-OXIDASE-RXN
xref: RHEA:21881
is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor

[Term]
id: GO:0050163
name: oxaloacetate tautomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: oxaloacetate = <stereo>enol</stereo>-oxaloacetate." [EC:5.3.2.2, RHEA:16024]
synonym: "oxalacetic keto-enol isomerase activity" EXACT [EC:5.3.2.2]
synonym: "oxaloacetate keto-enol tautomerase activity" EXACT [EC:5.3.2.2]
synonym: "oxaloacetate keto-enol-isomerase activity" EXACT [EC:5.3.2.2]
xref: EC:5.3.2.2
xref: KEGG:R00363
xref: MetaCyc:OXALOACETATE-TAUTOMERASE-RXN
xref: RHEA:16024
is_a: GO:0016862 ! intramolecular oxidoreductase activity, interconverting keto- and enol-groups

[Term]
id: GO:0050164
name: oxoglutarate dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + CoA + NADP(+) = CO(2) + NADPH + succinyl-CoA." [EC:1.2.1.52, RHEA:21403]
synonym: "2-oxoglutarate:NADP+ 2-oxidoreductase (CoA-succinylating)" EXACT [EC:1.2.1.52]
xref: EC:1.2.1.52
xref: KEGG:R00265
xref: MetaCyc:OXOGLUTARATE-DEHYDROGENASE-NADP+-RXN
xref: RHEA:21403
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050165
name: pantetheine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + pantetheine = ADP + pantetheine 4'-phosphate." [EC:2.7.1.34, MetaCyc:PANTETHEINE-KINASE-RXN]
synonym: "ATP:pantetheine 4'-phosphotransferase activity" EXACT [EC:2.7.1.34]
synonym: "pantetheine kinase (phosphorylating)" EXACT [EC:2.7.1.34]
xref: EC:2.7.1.34
xref: MetaCyc:PANTETHEINE-KINASE-RXN
xref: RHEA:22475
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0050166
name: pantoate 4-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-pantoate + NAD(+) = (R)-4-dehydropantoate + H(+) + NADH." [EC:1.1.1.106, RHEA:23003]
synonym: "(R)-pantoate:NAD+ 4-oxidoreductase activity" EXACT [EC:1.1.1.106]
synonym: "D-pantoate:NAD+ 4-oxidoreductase activity" EXACT [EC:1.1.1.106]
synonym: "panthothenase activity" EXACT [EC:1.1.1.106]
synonym: "pantoate dehydrogenase activity" EXACT [EC:1.1.1.106]
xref: EC:1.1.1.106
xref: KEGG:R02471
xref: MetaCyc:PANTOATE-4-DEHYDROGENASE-RXN
xref: RHEA:23003
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050167
name: pantothenoylcysteine decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-[(R)-pantothenoyl]-L-cysteine + H(+) = (R)-pantetheine + CO(2)." [EC:4.1.1.30, RHEA:15080]
synonym: "N-((R)-pantothenoyl)-L-cysteine carboxy-lyase activity" EXACT [EC:4.1.1.30]
synonym: "N-[(R)-pantothenoyl]-L-cysteine carboxy-lyase (pantetheine-forming)" EXACT [EC:4.1.1.30]
synonym: "N-[(R)-pantothenoyl]-L-cysteine carboxy-lyase activity" EXACT [EC:4.1.1.30]
synonym: "pantothenylcysteine decarboxylase activity" EXACT [EC:4.1.1.30]
xref: EC:4.1.1.30
xref: KEGG:R02972
xref: MetaCyc:PANTOTHENOYLCYSTEINE-DECARBOXYLASE-RXN
xref: RHEA:15080
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050168
name: pentanamidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + pentanamide = NH(4)(+) + valerate." [EC:3.5.1.50, RHEA:10003]
synonym: "pentanamide amidohydrolase activity" EXACT [EC:3.5.1.50]
synonym: "valeramidase activity" EXACT [EC:3.5.1.50]
xref: EC:3.5.1.50
xref: KEGG:R02938
xref: MetaCyc:PENTANAMIDASE-RXN
xref: RHEA:10003
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050169
name: peptide-tryptophan 2,3-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: peptide tryptophan + O2 = peptide formylkynurenine." [EC:1.13.11.26, MetaCyc:PEPTIDE-TRYPTOPHAN-23-DIOXYGENASE-RXN]
synonym: "peptide-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.26]
synonym: "peptidyltryptophan 2,3-dioxygenase activity" EXACT [EC:1.13.11.26]
synonym: "pyrrolooxygenase activity" EXACT [EC:1.13.11.26]
synonym: "tryptophan pyrrolooxygenase activity" EXACT [EC:1.13.11.26]
xref: EC:1.13.11.26
xref: MetaCyc:PEPTIDE-TRYPTOPHAN-23-DIOXYGENASE-RXN
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0050170
name: peptidyl-glutaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-N-peptidyl-L-glutamine + H2O = alpha-N-peptidyl-L-glutamate + NH3." [EC:3.5.1.43, MetaCyc:PEPTIDYL-GLUTAMINASE-RXN]
synonym: "peptideglutaminase activity" EXACT [EC:3.5.1.43]
synonym: "peptidoglutaminase activity" EXACT [EC:3.5.1.43]
synonym: "peptidoglutaminase I activity" NARROW [EC:3.5.1.43]
synonym: "peptidyl-L-glutamine amidohydrolase activity" EXACT [EC:3.5.1.43]
xref: EC:3.5.1.43
xref: MetaCyc:PEPTIDYL-GLUTAMINASE-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050171
name: phenol beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + a phenol = UDP + an aryl beta-D-glucoside." [EC:2.4.1.35, MetaCyc:PHENOL-BETA-GLUCOSYLTRANSFERASE-RXN]
synonym: "phenol b-glucosyltransferase activity" EXACT []
synonym: "phenol-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.35]
synonym: "UDP glucosyltransferase activity" EXACT [EC:2.4.1.35]
synonym: "UDP-glucose glucosyltransferase activity" EXACT [EC:2.4.1.35]
synonym: "UDP-glucose:phenol beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.35]
synonym: "UDPglucose:phenol beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.35]
synonym: "UDPglucosyltransferase activity" EXACT [EC:2.4.1.35]
synonym: "uridine diphosphoglucosyltransferase activity" EXACT [EC:2.4.1.35]
xref: EC:2.4.1.35
xref: MetaCyc:PHENOL-BETA-GLUCOSYLTRANSFERASE-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0050172
name: phenylalanine 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-phenylalanine + O(2) = 2-phenylacetamide + CO(2) + H(2)O." [EC:1.13.12.9, RHEA:10715]
subset: gosubset_prok
synonym: "L-phenylalanine oxidase (deaminating and decarboxylating)" EXACT [EC:1.13.12.9]
synonym: "l-phenylalanine oxidase (deaminating and decarboxylating) activity" EXACT [EC:1.13.12.9]
synonym: "L-phenylalanine:oxygen 2-oxidoreductase (decarboxylating)" EXACT [EC:1.13.12.9]
synonym: "phenylalanine (deaminating, decarboxylating) oxidase activity" EXACT [EC:1.13.12.9]
synonym: "phenylalanine (deaminating, decarboxylating)oxidase activity" EXACT [EC:1.13.12.9]
xref: EC:1.13.12.9
xref: KEGG:R00690
xref: MetaCyc:PHENYLALANINE-2-MONOOXYGENASE-RXN
xref: RHEA:10715
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)

[Term]
id: GO:0050173
name: phenylalanine adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-phenylalanine + ATP = N-adenylyl-L-phenylalanine + diphosphate + 2 H(+)." [EC:2.7.7.54, RHEA:17192]
synonym: "ATP:L-phenylalanine adenylyltransferase activity" EXACT [EC:2.7.7.54]
synonym: "ATP:phenylalanine adenylyltransferase activity" EXACT []
synonym: "L-phenylalanine adenylyltransferase activity" EXACT [EC:2.7.7.54]
xref: EC:2.7.7.54
xref: KEGG:R00687
xref: MetaCyc:PHENYLALANINE-ADENYLYLTRANSFERASE-RXN
xref: RHEA:17192
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0050174
name: phenylalanine decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-phenylalanine = phenylethylamine + CO2." [EC:4.1.1.53, MetaCyc:PHENYLALANINE-DECARBOXYLASE-RXN]
synonym: "aromatic L-amino acid decarboxylase activity" EXACT [EC:4.1.1.53]
synonym: "L-phenylalanine carboxy-lyase (phenylethylamine-forming)" EXACT [EC:4.1.1.53]
synonym: "L-phenylalanine carboxy-lyase activity" EXACT [EC:4.1.1.53]
synonym: "L-phenylalanine decarboxylase activity" EXACT [EC:4.1.1.53]
xref: EC:4.1.1.53
xref: MetaCyc:PHENYLALANINE-DECARBOXYLASE-RXN
xref: RHEA:19720
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050175
name: phenylalanine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-phenylalanine + H2O + NAD+ = phenylpyruvate + NH3 + NADH." [EC:1.4.1.20, MetaCyc:PHENYLALANINE-DEHYDROGENASE-RXN]
subset: gosubset_prok
synonym: "L-phenylalanine dehydrogenase activity" EXACT [EC:1.4.1.20]
synonym: "L-phenylalanine:NAD+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.20]
synonym: "PHD" RELATED [EC:1.4.1.20]
synonym: "PheDH activity" EXACT [EC:1.4.1.20]
xref: EC:1.4.1.20
xref: MetaCyc:PHENYLALANINE-DEHYDROGENASE-RXN
xref: RHEA:21411
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050176
name: phenylalanine N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-phenylalanine + acetyl-CoA = N-acetyl-L-phenylalanine + CoA + H(+)." [EC:2.3.1.53, RHEA:17804]
synonym: "acetyl-CoA-L-phenylalanine alpha-N-acetyltransferase activity" EXACT [EC:2.3.1.53]
synonym: "acetyl-CoA:L-phenylalanine N-acetyltransferase activity" EXACT [EC:2.3.1.53]
xref: EC:2.3.1.53
xref: KEGG:R00693
xref: MetaCyc:PHENYLALANINE-N-ACETYLTRANSFERASE-RXN
xref: RHEA:17804
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0050177
name: phenylpyruvate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenylpyruvate = phenylacetaldehyde + CO2." [EC:4.1.1.43, MetaCyc:PHENYLPYRUVATE-DECARBOXYLASE-RXN]
synonym: "phenylpyruvate carboxy-lyase (phenylacetaldehyde-forming)" EXACT [EC:4.1.1.43]
synonym: "phenylpyruvate carboxy-lyase activity" EXACT [EC:4.1.1.43]
xref: EC:4.1.1.43
xref: MetaCyc:PHENYLPYRUVATE-DECARBOXYLASE-RXN
xref: RHEA:14188
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050178
name: phenylpyruvate tautomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: keto-phenylpyruvate = enol-phenylpyruvate." [EC:5.3.2.1, MetaCyc:PHENYLPYRUVATE-TAUTOMERASE-RXN]
subset: gosubset_prok
synonym: "phenylpyruvate keto--enol tautomerase activity" EXACT [EC:5.3.2.1]
synonym: "phenylpyruvate keto-enol-isomerase activity" EXACT [EC:5.3.2.1]
synonym: "phenylpyruvic keto--enol isomerase activity" EXACT [EC:5.3.2.1]
xref: EC:5.3.2.1
xref: MetaCyc:PHENYLPYRUVATE-TAUTOMERASE-RXN
xref: RHEA:17100
is_a: GO:0016862 ! intramolecular oxidoreductase activity, interconverting keto- and enol-groups

[Term]
id: GO:0050179
name: phenylserine aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-threo-3-phenylserine = benzaldehyde + glycine." [EC:4.1.2.26, RHEA:21715]
synonym: "L-threo-3-phenylserine benzaldehyde-lyase (glycine-forming)" EXACT [EC:4.1.2.26]
synonym: "L-threo-3-phenylserine benzaldehyde-lyase activity" EXACT [EC:4.1.2.26]
xref: EC:4.1.2.26
xref: KEGG:R01766
xref: MetaCyc:PHENYLSERINE-ALDOLASE-RXN
xref: RHEA:21715
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0050180
name: phloretin hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + phloretin = H(+) + phloretate + phloroglucinol." [EC:3.7.1.4, RHEA:23399]
synonym: "2',4,4',6'-tetrahydroxydehydrochalcone 1,3,5-trihydroxybenzenehydrolase activity" EXACT [EC:3.7.1.4]
synonym: "lactase-phlorizin hydrolase" BROAD [EC:3.7.1.4]
xref: EC:3.7.1.4
xref: KEGG:R02901
xref: MetaCyc:PHLORETIN-HYDROLASE-RXN
xref: RHEA:23399
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0050181
name: phorbol-diester hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + phorbol 12,13-dibutanoate = butanoate + H(+) + phorbol 13-butanoate." [EC:3.1.1.51, RHEA:21319]
synonym: "12,13-diacylphorbate 12-acylhydrolase activity" EXACT [EC:3.1.1.51]
synonym: "diacylphorbate 12-hydrolase activity" EXACT [EC:3.1.1.51]
synonym: "PDEH" RELATED [EC:3.1.1.51]
synonym: "phorbol-12,13-diester 12-ester hydrolase activity" EXACT [EC:3.1.1.51]
xref: EC:3.1.1.51
xref: KEGG:R04119
xref: MetaCyc:PHORBOL-DIESTER-HYDROLASE-RXN
xref: RHEA:21319
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0050182
name: phosphate butyryltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: butanoyl-CoA + phosphate = butanoyl phosphate + CoA." [EC:2.3.1.19, RHEA:20895]
subset: gosubset_prok
synonym: "butanoyl-CoA:phosphate butanoyltransferase activity" EXACT [EC:2.3.1.19]
synonym: "phosphotransbutyrylase activity" EXACT [EC:2.3.1.19]
xref: EC:2.3.1.19
xref: KEGG:R01174
xref: MetaCyc:PHOSPHATE-BUTYRYLTRANSFERASE-RXN
xref: RHEA:20895
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0050183
name: phosphatidylcholine 12-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + H(+) + NADH + O(2) = 1-acyl-2-[(S)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + H(2)O + NAD(+)." [EC:1.14.13.26, RHEA:11371]
synonym: "1-acyl-2-oleoyl-sn-glycero-3-phosphocholine,NADH:oxygen oxidoreductase (12-hydroxylating)" EXACT [EC:1.14.13.26]
synonym: "oleate D12-hydroxylase activity" EXACT []
synonym: "oleate Delta(12)-hydroxylase activity" EXACT [EC:1.14.13.26]
synonym: "oleate delta12-hydroxylase activity" EXACT [EC:1.14.13.26]
synonym: "oleate delta12-monooxygenase activity" EXACT [EC:1.14.13.26]
synonym: "ricinoleic acid synthase activity" EXACT [EC:1.14.13.26]
xref: EC:1.14.13.26
xref: KEGG:R03476
xref: MetaCyc:PHOSPHATIDYLCHOLINE-12-MONOOXYGENASE-RXN
xref: RHEA:11371
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050184
name: phosphatidylcholine desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + NAD(+) = 1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine + H(+) + NADH." [EC:1.3.1.35, RHEA:12567]
synonym: "1-acyl-2-oleoyl-sn-glycero-3-phosphocholine:NAD+ delta12-oxidoreductase activity" EXACT [EC:1.3.1.35]
synonym: "linoleate synthase activity" EXACT [EC:1.3.1.35]
synonym: "oleate desaturase activity" EXACT [EC:1.3.1.35]
synonym: "oleoyl-CoA desaturase activity" EXACT [EC:1.3.1.35]
synonym: "oleoylphosphatidylcholine desaturase activity" EXACT [EC:1.3.1.35]
xref: EC:1.3.1.35
xref: KEGG:R03475
xref: MetaCyc:PHOSPHATIDYLCHOLINE-DESATURASE-RXN
xref: RHEA:12567
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050185
name: phosphatidylinositol deacylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + H(2)O = 1-acyl-sn-glycero-3-phospho-D-myo-inositol + a carboxylate + H(+)." [EC:3.1.1.52, RHEA:18004]
synonym: "1-phosphatidyl-D-myo-inositol 2-acylhydrolase activity" EXACT [EC:3.1.1.52]
synonym: "phosphatidylinositol phospholipase A2 activity" EXACT [EC:3.1.1.52]
xref: EC:3.1.1.52
xref: KEGG:R03360
xref: MetaCyc:PHOSPHATIDYLINOSITOL-DEACYLASE-RXN
xref: RHEA:18004
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0050186
name: phosphoadenylylsulfatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + H2O = adenosine 3',5'-bisphosphate + sulfate." [EC:3.6.2.2, MetaCyc:PHOSPHOADENYLYLSULFATASE-RXN]
synonym: "3'-phosphoadenylylsulfate sulfohydrolase activity" EXACT [EC:3.6.2.2]
synonym: "3-phosphoadenosine 5-phosphosulfate sulfatase activity" EXACT [EC:3.6.2.2]
synonym: "3-phosphoadenylyl sulfatase activity" EXACT [EC:3.6.2.2]
synonym: "PAPS sulfatase activity" EXACT [EC:3.6.2.2]
synonym: "phosphoadenylylsulphatase activity" EXACT []
xref: EC:3.6.2.2
xref: MetaCyc:PHOSPHOADENYLYLSULFATASE-RXN
xref: RHEA:11235
is_a: GO:0016819 ! hydrolase activity, acting on acid anhydrides, in sulfonyl-containing anhydrides

[Term]
id: GO:0050187
name: phosphoamidase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-phosphocreatine + H(2)O = creatine + phosphate." [EC:3.9.1.1, RHEA:12980]
synonym: "creatine phosphatase activity" EXACT [EC:3.9.1.1]
synonym: "phosphamide hydrolase activity" EXACT [EC:3.9.1.1]
xref: EC:3.9.1.1
xref: KEGG:R01882
xref: MetaCyc:PHOSPHOAMIDASE-RXN
xref: RHEA:12980
is_a: GO:0016825 ! hydrolase activity, acting on acid phosphorus-nitrogen bonds

[Term]
id: GO:0050188
name: phosphoenolpyruvate mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphoenolpyruvate = 3-phosphonopyruvate." [EC:5.4.2.9, RHEA:17016]
subset: gosubset_prok
synonym: "PEP mutase activity" EXACT [EC:5.4.2.9]
synonym: "PEP phosphomutase activity" EXACT [EC:5.4.2.9]
synonym: "PEPPM" RELATED [EC:5.4.2.9]
synonym: "phosphoenolpyruvate 2,3-phosphonomutase activity" EXACT [EC:5.4.2.9]
synonym: "phosphoenolpyruvate phosphomutase activity" EXACT [EC:5.4.2.9]
synonym: "phosphoenolpyruvate-phosphonopyruvate phosphomutase activity" EXACT [EC:5.4.2.9]
xref: EC:5.4.2.9
xref: KEGG:R00661
xref: MetaCyc:PHOSPHOENOLPYRUVATE-MUTASE-RXN
xref: RHEA:17016
is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases

[Term]
id: GO:0050189
name: phosphoenolpyruvate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + phosphoenolpyruvate = phosphate + pyruvate." [EC:3.1.3.60, RHEA:20000]
synonym: "PEP phosphatase activity" EXACT [EC:3.1.3.60]
synonym: "phosphoenolpyruvate phosphohydrolase activity" EXACT [EC:3.1.3.60]
xref: EC:3.1.3.60
xref: KEGG:R00208
xref: MetaCyc:PHOSPHOENOLPYRUVATE-PHOSPHATASE-RXN
xref: RHEA:20000
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0050190
name: phosphoglucokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate + ATP = alpha-D-glucose 1,6-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.10, RHEA:13380]
synonym: "ATP:alpha-D-glucose-1-phosphate 6-phosphotransferase activity" EXACT [EC:2.7.1.10]
synonym: "ATP:D-glucose-1-phosphate 6-phosphotransferase activity" EXACT [EC:2.7.1.10]
synonym: "glucose-phosphate kinase activity" EXACT [EC:2.7.1.10]
synonym: "phosphoglucokinase (phosphorylating)" EXACT [EC:2.7.1.10]
xref: EC:2.7.1.10
xref: KEGG:R00949
xref: MetaCyc:PHOSPHOGLUCOKINASE-RXN
xref: RHEA:13380
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0050191
name: phosphoglycerate kinase (GTP) activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-phospho-D-glycerate + GTP = 3-phospho-D-glyceroyl phosphate + GDP + H(+)." [EC:2.7.2.10, RHEA:23335]
synonym: "GTP:3-phospho-D-glycerate 1-phosphotransferase activity" EXACT [EC:2.7.2.10]
xref: EC:2.7.2.10
xref: KEGG:R01517
xref: MetaCyc:PHOSPHOGLYCERATE-KINASE-GTP-RXN
xref: RHEA:23335
is_a: GO:0016301 ! kinase activity
is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor

[Term]
id: GO:0050192
name: phosphoglycerate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-phospho-D-glycerate + H(2)O = D-glycerate + phosphate." [EC:3.1.3.20, RHEA:21159]
synonym: "D-2-phosphoglycerate phosphatase activity" EXACT [EC:3.1.3.20]
synonym: "D-glycerate-2-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.20]
synonym: "glycerophosphate phosphatase activity" EXACT [EC:3.1.3.20]
xref: EC:3.1.3.20
xref: KEGG:R01748
xref: MetaCyc:PHOSPHOGLYCERATE-PHOSPHATASE-RXN
xref: RHEA:21159
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0050193
name: phosphoketolase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-xylulose 5-phosphate + phosphate = acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O." [EC:4.1.2.9, MetaCyc:PHOSPHOKETOLASE-RXN]
subset: gosubset_prok
synonym: "D-xylulose-5-phosphate D-glyceraldehyde-3-phosphate-lyase (adding phosphate; acetyl-phosphate-forming)" EXACT [EC:4.1.2.9]
synonym: "D-xylulose-5-phosphate D-glyceraldehyde-3-phosphate-lyase (phosphate-acetylating) activity" EXACT [EC:4.1.2.9]
synonym: "xylulose-5-phosphate phosphoketolase activity" EXACT [EC:4.1.2.9]
xref: EC:4.1.2.9
xref: MetaCyc:PHOSPHOKETOLASE-RXN
xref: RHEA:10471
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0050194
name: phosphonoacetaldehyde hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + phosphonoacetaldehyde = acetaldehyde + H(+) + phosphate." [EC:3.11.1.1, RHEA:18908]
subset: gosubset_prok
synonym: "2-oxoethylphosphonate phosphonohydrolase activity" EXACT [EC:3.11.1.1]
synonym: "2-phosphonoacetylaldehyde phosphonohydrolase activity" EXACT [EC:3.11.1.1]
synonym: "phosphonatase activity" EXACT [EC:3.11.1.1]
synonym: "phosphonoacetylaldehyde phosphonohydrolase activity" EXACT [EC:3.11.1.1]
xref: EC:3.11.1.1
xref: KEGG:R00747
xref: MetaCyc:PHOSPHONOACETALDEHYDE-HYDROLASE-RXN
xref: RHEA:18908
is_a: GO:0016827 ! hydrolase activity, acting on acid carbon-phosphorus bonds

[Term]
id: GO:0050195
name: phosphoribokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-ribose 5-phosphate + ATP = D-ribose 1,5-diphosphate + ADP + 2 H(+)." [EC:2.7.1.18, RHEA:21219]
synonym: "ATP:D-ribose-5-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.18]
synonym: "phosphoribokinase (phosphorylating)" EXACT [EC:2.7.1.18]
xref: EC:2.7.1.18
xref: KEGG:R01050
xref: MetaCyc:PHOSPHORIBOKINASE-RXN
xref: RHEA:21219
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0050196
name: [phosphorylase] phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: [phosphorylase a] + 4 H2O = 2 [phosphorylase b] + 4 phosphate." [EC:3.1.3.17, MetaCyc:PHOSPHORYLASE-PHOSPHATASE-RXN]
synonym: "glycogen phosphorylase phosphatase activity" EXACT [EC:3.1.3.17]
synonym: "phosphorylase a phosphatase activity" EXACT [EC:3.1.3.17]
synonym: "phosphorylase a phosphohydrolase activity" EXACT [EC:3.1.3.17]
synonym: "phosphorylase phosphatase activity" EXACT []
synonym: "PR-enzyme" RELATED [EC:3.1.3.17]
synonym: "protein phosphatase C" RELATED [EC:3.1.3.17]
synonym: "type 1 protein phosphatase activity" EXACT [EC:3.1.3.17]
xref: EC:3.1.3.17
xref: MetaCyc:PHOSPHORYLASE-PHOSPHATASE-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0050197
name: phytanate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + CoA + phytanate = AMP + diphosphate + H(+) + phytanoyl-CoA." [EC:6.2.1.24, RHEA:21383]
subset: gosubset_prok
synonym: "phytanate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.24]
synonym: "phytanoyl-CoA ligase activity" EXACT [EC:6.2.1.24]
xref: EC:6.2.1.24
xref: KEGG:R03631
xref: MetaCyc:PHYTANATE--COA-LIGASE-RXN
xref: Reactome:REACT_113403 "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate, Taeniopygia guttata"
xref: Reactome:REACT_114248 "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_17000 "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate, Homo sapiens"
xref: Reactome:REACT_30479 "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate, Xenopus tropicalis"
xref: Reactome:REACT_32058 "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate, Canis familiaris"
xref: Reactome:REACT_34780 "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate, Danio rerio"
xref: Reactome:REACT_82853 "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate, Sus scrofa"
xref: Reactome:REACT_86583 "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate, Bos taurus"
xref: Reactome:REACT_88801 "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate, Mus musculus"
xref: Reactome:REACT_89795 "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate, Rattus norvegicus"
xref: Reactome:REACT_92899 "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate, Mycobacterium tuberculosis"
xref: RHEA:21383
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0050198
name: pinosylvin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-cinnamoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4 CO(2) + 4 CoA + pinosylvin." [EC:2.3.1.146, RHEA:12555]
synonym: "malonyl-CoA:cinnamoyl-CoA malonyltransferase (cyclizing)" EXACT [EC:2.3.1.146]
synonym: "pine stilbene synthase activity" EXACT [EC:2.3.1.146]
synonym: "stilbene synthase activity" BROAD [EC:2.3.1.146]
xref: EC:2.3.1.146
xref: KEGG:R02505
xref: MetaCyc:PINOSYLVIN-SYNTHASE-RXN
xref: RHEA:12555
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0050199
name: piperidine N-piperoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (E,E)-piperoyl-CoA + piperidine = N-[(E,E)-piperoyl]piperidine + CoA + H(+)." [EC:2.3.1.145, RHEA:14564]
synonym: "(E,E)-piperoyl-CoA:piperidine N-piperoyltransferase activity" EXACT [EC:2.3.1.145]
synonym: "piperidine piperoyltransferase activity" EXACT [EC:2.3.1.145]
synonym: "piperoyl-CoA:piperidine N-piperoyltransferase activity" EXACT [EC:2.3.1.145]
xref: EC:2.3.1.145
xref: KEGG:R03994
xref: MetaCyc:PIPERIDINE-N-PIPEROYLTRANSFERASE-RXN
xref: RHEA:14564
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0050200
name: plasmalogen synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + 1-O-alk-1-enyl-glycero-3-phosphocholine = CoA + plasmenylcholine." [EC:2.3.1.25, MetaCyc:PLASMALOGEN-SYNTHASE-RXN]
synonym: "1-alkenyl-glycero-3-phosphorylcholine:acyl-CoA acyltransferase activity" EXACT [EC:2.3.1.25]
synonym: "acyl-CoA:1-O-alk-1-enyl-glycero-3-phosphocholine 2-O-acyltransferase activity" EXACT [EC:2.3.1.25]
synonym: "lysoplasmenylcholine acyltransferase activity" EXACT [EC:2.3.1.25]
synonym: "O-1-alkenylglycero-3-phosphorylcholine acyltransferase activity" EXACT [EC:2.3.1.25]
xref: EC:2.3.1.25
xref: MetaCyc:PLASMALOGEN-SYNTHASE-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0050201
name: fucokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-fucose + ATP = beta-L-fucose 1-phosphate + ADP + 2 H(+)." [EC:2.7.1.52, RHEA:13244]
synonym: "ATP:6-deoxy-L-galactose 1-phosphotransferase activity" EXACT [EC:2.7.1.52]
synonym: "ATP:beta-L-fucose 1-phosphotransferase activity" EXACT [EC:2.7.1.52]
synonym: "fucokinase (phosphorylating) activity" EXACT [EC:2.7.1.52]
synonym: "fucose kinase activity" EXACT [EC:2.7.1.52]
synonym: "L-fucokinase activity" EXACT [EC:2.7.1.52]
synonym: "L-fucose kinase activity" EXACT [EC:2.7.1.52]
xref: EC:2.7.1.52
xref: KEGG:R03161
xref: MetaCyc:FUCOKINASE-RXN
xref: RHEA:13244
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0050202
name: octopamine dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-(4-hydroxyphenyl)-2-aminoethanol = (4-hydroxyphenyl)acetaldehyde + NH(4)(+)." [EC:4.2.1.87, RHEA:18176]
synonym: "octopamine hydro-lyase (deaminating)" EXACT [EC:4.2.1.87]
synonym: "octopamine hydro-lyase [deaminating; (4-hydroxyphenyl)acetaldehyde-forming]" RELATED [EC:4.2.1.87]
synonym: "octopamine hydrolyase activity" EXACT [EC:4.2.1.87]
xref: EC:4.2.1.87
xref: KEGG:R03358
xref: MetaCyc:OCTOPAMINE-DEHYDRATASE-RXN
xref: RHEA:18176
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050203
name: oxalate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + CoA + oxalate = AMP + diphosphate + H(+) + oxalyl-CoA." [EC:6.2.1.8, RHEA:18296]
synonym: "oxalate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.8]
synonym: "oxalyl coenzyme A synthetase activity" EXACT [EC:6.2.1.8]
synonym: "oxalyl-CoA synthetase activity" EXACT [EC:6.2.1.8]
xref: EC:6.2.1.8
xref: KEGG:R01558
xref: MetaCyc:OXALATE--COA-LIGASE-RXN
xref: RHEA:18296
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0050204
name: oxalomalate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-oxalomalate = glyoxylate + oxaloacetate." [EC:4.1.3.13, RHEA:22035]
synonym: "3-oxalomalate glyoxylate-lyase (oxaloacetate-forming)" EXACT [EC:4.1.3.13]
synonym: "3-oxalomalate glyoxylate-lyase activity" EXACT [EC:4.1.3.13]
xref: EC:4.1.3.13
xref: KEGG:R00477
xref: MetaCyc:OXALOMALATE-LYASE-RXN
xref: RHEA:22035
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0050205
name: oxamate carbamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: carbamoyl phosphate + oxamate = oxalurate + phosphate." [EC:2.1.3.5, RHEA:22987]
synonym: "carbamoyl-phosphate:oxamate carbamoyltransferase activity" EXACT [EC:2.1.3.5]
synonym: "oxamic transcarbamylase activity" EXACT [EC:2.1.3.5]
xref: EC:2.1.3.5
xref: KEGG:R02937
xref: MetaCyc:OXAMATE-CARBAMOYLTRANSFERASE-RXN
xref: RHEA:22987
is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity

[Term]
id: GO:0050206
name: oximinotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-(hydroxyimino)propanoate + acetone = acetone oxime + pyruvate." [EC:2.6.3.1, RHEA:11627]
synonym: "oximase activity" EXACT [EC:2.6.3.1]
synonym: "pyruvate-acetone oximinotransferase activity" EXACT [EC:2.6.3.1]
synonym: "pyruvate-oxime:acetone oximinotransferase activity" EXACT [EC:2.6.3.1]
synonym: "transoximase activity" EXACT [EC:2.6.3.1]
synonym: "transoximinase activity" EXACT [EC:2.6.3.1]
xref: EC:2.6.3.1
xref: KEGG:R03796
xref: MetaCyc:OXIMINOTRANSFERASE-RXN
xref: RHEA:11627
is_a: GO:0016770 ! oximinotransaminase activity

[Term]
id: GO:0050207
name: plasmanylethanolamine desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + donor-H2 + O2 = O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + acceptor + 2 H2O." [EC:1.14.99.19, MetaCyc:PLASMANYLETHANOLAMINE-DESATURASE-RXN]
synonym: "1-O-alkyl 2-acyl-sn-glycero-3-phosphorylethanolamine desaturase activity" EXACT [EC:1.14.99.19]
synonym: "1-O-alkyl-2-acyl-sn-glycero-3-phosphorylethanolamine desaturase activity" EXACT [EC:1.14.99.19]
synonym: "alkylacylglycero-phosphorylethanolamine dehydrogenase activity" EXACT [EC:1.14.99.19]
synonym: "alkylacylglycerophosphoethanolamine desaturase activity" EXACT [EC:1.14.99.19]
synonym: "dehydrogenase, alkyl-acylglycerophosphorylethanolamine" EXACT [EC:1.14.99.19]
synonym: "O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine,hydrogen-donor:oxygen oxidoreductase activity" EXACT [EC:1.14.99.19]
synonym: "plasmenylethanolamine desaturase activity" EXACT []
xref: EC:1.14.99.19
xref: MetaCyc:PLASMANYLETHANOLAMINE-DESATURASE-RXN
xref: RHEA:22959
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0050208
name: polysialic-acid O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + an alpha-2,8-linked polymer of sialic acid = CoA + polysialic acid acetylated at O-7 or O-9." [EC:2.3.1.136, MetaCyc:POLYSIALIC-ACID-O-ACETYLTRANSFERASE-RXN]
synonym: "acetyl-CoA:polysialic-acid O-acetyltransferase activity" EXACT [EC:2.3.1.136]
synonym: "lecithin retinol acyl transferase activity" EXACT [EC:2.3.1.136]
synonym: "lecithin:retinol acyltransferase activity" EXACT [EC:2.3.1.136]
synonym: "LRAT" RELATED [EC:2.3.1.136]
synonym: "retinyl ester synthase activity" EXACT [EC:2.3.1.136]
xref: EC:2.3.1.136
xref: MetaCyc:POLYSIALIC-ACID-O-ACETYLTRANSFERASE-RXN
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0050209
name: polyvinyl-alcohol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: polyvinyl alcohol + O2 = oxidized polyvinyl alcohol + H2O2." [EC:1.1.3.30, MetaCyc:POLYVINYL-ALCOHOL-OXIDASE-RXN]
synonym: "dehydrogenase, polyvinyl alcohol" EXACT [EC:1.1.3.30]
synonym: "polyvinyl-alcohol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.30]
synonym: "PVA oxidase activity" EXACT [EC:1.1.3.30]
xref: EC:1.1.3.30
xref: MetaCyc:POLYVINYL-ALCOHOL-OXIDASE-RXN
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0050210
name: prenyl-diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: prenyl diphosphate + H2O = prenol + diphosphate." [EC:3.1.7.1, MetaCyc:PRENYL-PYROPHOSPHATASE-RXN]
synonym: "prenol pyrophosphatase activity" EXACT [EC:3.1.7.1]
synonym: "prenyl-diphosphate diphosphohydrolase activity" EXACT [EC:3.1.7.1]
synonym: "prenyl-pyrophosphatase activity" EXACT []
synonym: "prenylphosphatase activity" EXACT [EC:3.1.7.1]
xref: EC:3.1.7.1
xref: MetaCyc:PRENYL-PYROPHOSPHATASE-RXN
xref: RHEA:21499
is_a: GO:0016794 ! diphosphoric monoester hydrolase activity

[Term]
id: GO:0050211
name: procollagen galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-galactose + procollagen 5-hydroxy-L-lysine = UDP + procollagen 5-(D-galactosyloxy)-L-lysine." [EC:2.4.1.50, MetaCyc:PROCOLLAGEN-GALACTOSYLTRANSFERASE-RXN]
synonym: "collagen galactosyltransferase activity" EXACT [EC:2.4.1.50]
synonym: "collagen hydroxylysyl galactosyltransferase activity" EXACT [EC:2.4.1.50]
synonym: "hydroxylysine galactosyltransferase activity" EXACT [EC:2.4.1.50]
synonym: "UDP galactose-collagen galactosyltransferase activity" EXACT [EC:2.4.1.50]
synonym: "UDP-galactose:procollagen-5-hydroxy-L-lysine D-galactosyltransferase activity" EXACT [EC:2.4.1.50]
synonym: "UDPgalactose:5-hydroxylysine-collagen galactosyltransferase activity" EXACT [EC:2.4.1.50]
synonym: "UDPgalactose:procollagen-5-hydroxy-L-lysine D-galactosyltransferase activity" EXACT [EC:2.4.1.50]
synonym: "uridine diphosphogalactose-collagen galactosyltransferase activity" EXACT [EC:2.4.1.50]
xref: EC:2.4.1.50
xref: MetaCyc:PROCOLLAGEN-GALACTOSYLTRANSFERASE-RXN
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0050212
name: progesterone 11-alpha-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: AH(2) + O(2) + progesterone = 11alpha-hydroxyprogesterone + A + H(2)O." [EC:1.14.99.14, RHEA:18208]
synonym: "progesterone 11-alpha-hydroxylase activity" EXACT [EC:1.14.99.14]
synonym: "progesterone 11a-monooxygenase activity" EXACT []
synonym: "progesterone 11alpha-hydroxylase activity" EXACT [EC:1.14.99.14]
synonym: "progesterone 11alpha-monooxygenase activity" EXACT [EC:1.14.99.14]
synonym: "progesterone,hydrogen-donor:oxygen oxidoreductase (11alpha-hydroxylating)" EXACT [EC:1.14.99.14]
xref: EC:1.14.99.14
xref: KEGG:R02214
xref: MetaCyc:PROGESTERONE-11-ALPHA-MONOOXYGENASE-RXN
xref: RHEA:18208
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0050213
name: progesterone 5-alpha-reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-alpha-pregnan-3,20-dione + NADP+ = progesterone + NADPH." [EC:1.3.1.30, MetaCyc:PROGESTERONE-5-ALPHA-REDUCTASE-RXN]
synonym: "5alpha-pregnan-3,20-dione:NADP+ 5-oxidoreductase activity" EXACT [EC:1.3.1.30]
synonym: "delta4-steroid 5alpha-reductase (progesterone)" EXACT [EC:1.3.1.30]
synonym: "progesterone 5a-reductase activity" EXACT []
synonym: "progesterone 5alpha-reductase activity" EXACT [EC:1.3.1.30]
synonym: "steroid 5-alpha-reductase activity" BROAD [EC:1.3.1.30]
xref: EC:1.3.1.30
xref: MetaCyc:PROGESTERONE-5-ALPHA-REDUCTASE-RXN
xref: RHEA:21955
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050214
name: progesterone monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: AH(2) + O(2) + progesterone = A + H(2)O + testosterone acetate." [EC:1.14.99.4, RHEA:11987]
synonym: "progesterone hydroxylase activity" EXACT [EC:1.14.99.4]
synonym: "progesterone,hydrogen-donor:oxygen oxidoreductase (hydroxylating)" EXACT [EC:1.14.99.4]
xref: EC:1.14.99.4
xref: KEGG:R02212
xref: MetaCyc:PROGESTERONE-MONOOXYGENASE-RXN
xref: RHEA:11987
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0050215
name: propanediol dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: propane-1,2-diol = H(2)O + propanal." [EC:4.2.1.28, RHEA:14572]
subset: gosubset_prok
synonym: "1,2-propanediol dehydratase activity" EXACT [EC:4.2.1.28]
synonym: "adenosylcobalamin-dependent diol dehydratase activity" EXACT [EC:4.2.1.28]
synonym: "coenzyme B12-dependent diol dehydrase activity" EXACT [EC:4.2.1.28]
synonym: "diol dehydrase activity" EXACT [EC:4.2.1.28]
synonym: "diol dehydratase activity" EXACT [EC:4.2.1.28]
synonym: "dioldehydratase activity" EXACT [EC:4.2.1.28]
synonym: "DL-1,2-propanediol hydro-lyase activity" EXACT [EC:4.2.1.28]
synonym: "meso-2,3-butanediol dehydrase activity" EXACT [EC:4.2.1.28]
synonym: "propane-1,2-diol hydro-lyase (propanal-forming)" EXACT [EC:4.2.1.28]
synonym: "propane-1,2-diol hydro-lyase activity" EXACT [EC:4.2.1.28]
synonym: "propanediol dehydrase activity" EXACT [EC:4.2.1.28]
xref: EC:4.2.1.28
xref: KEGG:R02376
xref: MetaCyc:PROPANEDIOL-DEHYDRATASE-RXN
xref: RHEA:14572
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050216
name: propanediol-phosphate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(+) + propane-1,2-diol 1-phosphate = H(+) + hydroxyacetone phosphate + NADH." [EC:1.1.1.7, RHEA:21587]
xref: EC:1.1.1.7
xref: KEGG:R04236
xref: MetaCyc:PROPANEDIOL-PHOSPHATE-DEHYDROGENASE-RXN
xref: RHEA:21587
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050217
name: propioin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxyhexan-3-one = 2 propanal." [EC:4.1.2.35, RHEA:11103]
synonym: "4-hydroxy-3-hexanone aldolase activity" EXACT [EC:4.1.2.35]
synonym: "4-hydroxy-3-hexanone propanal-lyase (propanal-forming)" EXACT [EC:4.1.2.35]
synonym: "4-hydroxy-3-hexanone propanal-lyase activity" EXACT [EC:4.1.2.35]
xref: EC:4.1.2.35
xref: KEGG:R00038
xref: MetaCyc:PROPIOIN-SYNTHASE-RXN
xref: RHEA:11103
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0050218
name: propionate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA." [EC:6.2.1.17, MetaCyc:PROPIONATE--COA-LIGASE-RXN]
subset: gosubset_prok
synonym: "propanoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.17]
synonym: "propionyl-CoA synthetase activity" EXACT [EC:6.2.1.17]
xref: EC:6.2.1.17
xref: MetaCyc:PROPIONATE--COA-LIGASE-RXN
xref: RHEA:20376
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0050219
name: prostaglandin-A1 delta-isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: prostaglandin A1 = prostaglandin C1." [EC:5.3.3.9, RHEA:10463]
synonym: "(13E)-(15S)-15-hydroxy-9-oxoprosta-10,13-dienoate delta10-delta11-isomerase activity" EXACT [EC:5.3.3.9]
synonym: "prostaglandin A isomerase activity" EXACT [EC:5.3.3.9]
synonym: "prostaglandin-A1 D-isomerase activity" EXACT []
xref: EC:5.3.3.9
xref: KEGG:R04565
xref: MetaCyc:PROSTAGLANDIN-A1-DELTA-ISOMERASE-RXN
xref: RHEA:10463
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0050220
name: prostaglandin-E synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: prostaglandin H(2) = prostaglandin E(2)." [EC:5.3.99.3, RHEA:12896]
synonym: "(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate E-isomerase activity" EXACT [EC:5.3.99.3]
synonym: "endoperoxide isomerase activity" EXACT [EC:5.3.99.3]
synonym: "PGE isomerase activity" EXACT [EC:5.3.99.3]
synonym: "PGE2 isomerase activity" EXACT [EC:5.3.99.3]
synonym: "PGH-PGE isomerase activity" EXACT [EC:5.3.99.3]
synonym: "prostaglandin endoperoxide E isomerase activity" EXACT [EC:5.3.99.3]
synonym: "prostaglandin endoperoxide E2 isomerase activity" EXACT [EC:5.3.99.3]
synonym: "prostaglandin H-E isomerase activity" EXACT [EC:5.3.99.3]
synonym: "prostaglandin R-prostaglandin E isomerase activity" EXACT [EC:5.3.99.3]
synonym: "Prostaglandin-H(2) E-isomerase activity" EXACT [EC:5.3.99.3]
synonym: "prostaglandin-H2 E-isomerase activity" EXACT [EC:5.3.99.3]
xref: EC:5.3.99.3
xref: KEGG:R02265
xref: MetaCyc:PROSTAGLANDIN-E-SYNTHASE-RXN
xref: Reactome:REACT_108636 "Prostaglandin E synthase isomerizes PGH2 to PGE2, Sus scrofa"
xref: Reactome:REACT_15459 "Prostaglandin E synthase isomerizes PGH2 to PGE2, Homo sapiens"
xref: Reactome:REACT_29551 "Prostaglandin E synthase isomerizes PGH2 to PGE2, Schizosaccharomyces pombe"
xref: Reactome:REACT_34225 "Prostaglandin E synthase isomerizes PGH2 to PGE2, Drosophila melanogaster"
xref: Reactome:REACT_80918 "Prostaglandin E synthase isomerizes PGH2 to PGE2, Xenopus tropicalis"
xref: Reactome:REACT_81983 "Prostaglandin E synthase isomerizes PGH2 to PGE2, Mus musculus"
xref: Reactome:REACT_83117 "Prostaglandin E synthase isomerizes PGH2 to PGE2, Taeniopygia guttata"
xref: Reactome:REACT_85007 "Prostaglandin E synthase isomerizes PGH2 to PGE2, Arabidopsis thaliana"
xref: Reactome:REACT_85731 "Prostaglandin E synthase isomerizes PGH2 to PGE2, Gallus gallus"
xref: Reactome:REACT_89871 "Prostaglandin E synthase isomerizes PGH2 to PGE2, Saccharomyces cerevisiae"
xref: Reactome:REACT_92557 "Prostaglandin E synthase isomerizes PGH2 to PGE2, Plasmodium falciparum"
xref: Reactome:REACT_93928 "Prostaglandin E synthase isomerizes PGH2 to PGE2, Oryza sativa"
xref: Reactome:REACT_93943 "Prostaglandin E synthase isomerizes PGH2 to PGE2, Caenorhabditis elegans"
xref: Reactome:REACT_96399 "Prostaglandin E synthase isomerizes PGH2 to PGE2, Canis familiaris"
xref: Reactome:REACT_96402 "Prostaglandin E synthase isomerizes PGH2 to PGE2, Dictyostelium discoideum"
xref: Reactome:REACT_96862 "Prostaglandin E synthase isomerizes PGH2 to PGE2, Bos taurus"
xref: Reactome:REACT_99780 "Prostaglandin E synthase isomerizes PGH2 to PGE2, Danio rerio"
xref: RHEA:12896
is_a: GO:0016860 ! intramolecular oxidoreductase activity

[Term]
id: GO:0050221
name: prostaglandin-E2 9-reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH." [EC:1.1.1.189, MetaCyc:PROSTAGLANDIN-E2-9-REDUCTASE-RXN]
synonym: "(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP+ 9-oxidoreductase activity" EXACT [EC:1.1.1.189]
synonym: "9-keto-prostaglandin E(2) reductase activity" EXACT [EC:1.1.1.189]
synonym: "9-keto-prostaglandin E2 reductase activity" EXACT [EC:1.1.1.189]
synonym: "9-ketoprostaglandin reductase activity" EXACT [EC:1.1.1.189]
synonym: "PGE(2) 9-ketoreductase activity" EXACT [EC:1.1.1.189]
synonym: "PGE(2) 9-oxoreductase activity" EXACT [EC:1.1.1.189]
synonym: "PGE-9-ketoreductase activity" EXACT [EC:1.1.1.189]
synonym: "PGE2 9-ketoreductase activity" EXACT [EC:1.1.1.189]
synonym: "PGE2 9-oxoreductase activity" EXACT [EC:1.1.1.189]
synonym: "PGE2-9-ketoreductase activity" EXACT [EC:1.1.1.189]
synonym: "PGE2-9-OR" RELATED [EC:1.1.1.189]
synonym: "prostaglandin E 9-ketoreductase activity" EXACT [EC:1.1.1.189]
synonym: "prostaglandin E2-9-oxoreductase activity" EXACT [EC:1.1.1.189]
synonym: "prostaglandin-E(2) 9-oxoreductase activity" EXACT [EC:1.1.1.189]
synonym: "prostaglandin-E2 9-oxoreductase activity" EXACT [EC:1.1.1.189]
synonym: "reductase, 15-hydroxy-9-oxoprostaglandin" EXACT [EC:1.1.1.189]
xref: EC:1.1.1.189
xref: MetaCyc:PROSTAGLANDIN-E2-9-REDUCTASE-RXN
xref: RHEA:24511
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050223
name: protocatechuate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,4-dihydroxybenzoate + H(+) = catechol + CO(2)." [EC:4.1.1.63, RHEA:22419]
synonym: "3,4-dihydrobenzoate decarboxylase activity" EXACT [EC:4.1.1.63]
synonym: "3,4-dihydroxybenzoate carboxy-lyase (catechol-forming)" EXACT [EC:4.1.1.63]
synonym: "3,4-dihydroxybenzoate decarboxylase activity" EXACT [EC:4.1.1.63]
synonym: "protocatechuate carboxy-lyase activity" EXACT [EC:4.1.1.63]
xref: EC:4.1.1.63
xref: KEGG:R00822
xref: MetaCyc:PROTOCATECHUATE-DECARBOXYLASE-RXN
xref: RHEA:22419
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050224
name: prunasin beta-glucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-prunasin + H(2)O = D-glucose + mandelonitrile." [EC:3.2.1.118, RHEA:16492]
synonym: "prunasin b-glucosidase activity" EXACT []
synonym: "prunasin beta-D-glucohydrolase activity" EXACT [EC:3.2.1.118]
synonym: "prunasin hydrolase activity" EXACT [EC:3.2.1.118]
xref: EC:3.2.1.118
xref: KEGG:R02558
xref: MetaCyc:PRUNASIN-BETA-GLUCOSIDASE-RXN
xref: RHEA:16492
is_a: GO:0008422 ! beta-glucosidase activity

[Term]
id: GO:0050225
name: pseudouridine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + pseudouridine = ADP + 2 H(+) + pseudouridine 5'-phosphate." [EC:2.7.1.83, RHEA:22451]
synonym: "ATP:pseudouridine 5'-phosphotransferase activity" EXACT [EC:2.7.1.83]
synonym: "pseudouridine kinase (phosphorylating)" EXACT [EC:2.7.1.83]
xref: EC:2.7.1.83
xref: KEGG:R03315
xref: MetaCyc:PSEUDOURIDINE-KINASE-RXN
xref: RHEA:22451
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0050226
name: psychosine sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + galactosylsphingosine = adenosine 3',5'-bisphosphate + psychosine sulfate." [EC:2.8.2.13, MetaCyc:PSYCHOSINE-SULFOTRANSFERASE-RXN]
synonym: "3'-phosphoadenosine 5'-phosphosulfate-psychosine sulphotransferase activity" EXACT [EC:2.8.2.13]
synonym: "3'-phosphoadenylyl-sulfate:galactosylsphingosine sulfotransferase activity" EXACT [EC:2.8.2.13]
synonym: "PAPS:psychosine sulphotransferase activity" EXACT [EC:2.8.2.13]
synonym: "psychosine sulphotransferase activity" EXACT []
xref: EC:2.8.2.13
xref: MetaCyc:PSYCHOSINE-SULFOTRANSFERASE-RXN
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0050227
name: pteridine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-amino-4-hydroxypteridine + O2 = 2-amino-4,7-dihydroxypteridine + unknown." [EC:1.17.3.1, MetaCyc:PTERIDINE-OXIDASE-RXN]
synonym: "2-amino-4-hydroxypteridine:oxygen oxidoreductase (7-hydroxylating)" EXACT [EC:1.17.3.1]
xref: EC:1.17.3.1
xref: MetaCyc:PTERIDINE-OXIDASE-RXN
is_a: GO:0016727 ! oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor

[Term]
id: GO:0050228
name: pterin deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-amino-4-hydroxypteridine + H2O = 2,4-dihydroxypteridine + NH3." [EC:3.5.4.11, MetaCyc:PTERIN-DEAMINASE-RXN]
synonym: "2-amino-4-hydroxypteridine aminohydrolase activity" EXACT [EC:3.5.4.11]
synonym: "acrasinase activity" EXACT [EC:3.5.4.11]
xref: EC:3.5.4.11
xref: MetaCyc:PTERIN-DEAMINASE-RXN
xref: RHEA:11907
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0050229
name: pterocarpin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: medicarpin + NADP+ = vestitone + NADPH." [EC:1.1.1.246, MetaCyc:PTEROCARPIN-SYNTHASE-RXN]
synonym: "medicarpin:NADP+ 2'-oxidoreductase activity" EXACT [EC:1.1.1.246]
synonym: "pterocarpan synthase activity" EXACT [EC:1.1.1.246]
xref: EC:1.1.1.246
xref: MetaCyc:PTEROCARPIN-SYNTHASE-RXN
xref: RHEA:13536
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050230
name: purine imidazole-ring cyclase activity
namespace: molecular_function
def: "Catalysis of the reaction: DNA 4,6-diamino-5-formamidopyrimidine = DNA adenine + H2O." [EC:4.3.2.4, MetaCyc:PURINE-IMIDAZOLE-RING-CYCLASE-RXN]
synonym: "DNA-4,6-diamino-5-formamidopyrimidine 8-C,9-N-lyase (cyclizing)" EXACT [EC:4.3.2.4]
synonym: "DNA-4,6-diamino-5-formamidopyrimidine 8-C,9-N-lyase (cyclizing; DNA-adenine-forming)" EXACT [EC:4.3.2.4]
synonym: "DNA-4,6-diamino-5-formamidopyrimidine C8-N9-lyase (cyclizing; DNA-adenine-forming)" EXACT [EC:4.3.2.4]
xref: EC:4.3.2.4
xref: MetaCyc:PURINE-IMIDAZOLE-RING-CYCLASE-RXN
is_a: GO:0009975 ! cyclase activity
is_a: GO:0016842 ! amidine-lyase activity

[Term]
id: GO:0050231
name: putrescine carbamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: carbamoyl phosphate + putrescine = N-carbamoylputrescine + H(+) + phosphate." [EC:2.1.3.6, RHEA:21939]
subset: gosubset_prok
synonym: "carbamoyl-phosphate:putrescine carbamoyltransferase activity" EXACT [EC:2.1.3.6]
synonym: "PTCase activity" EXACT [EC:2.1.3.6]
synonym: "putrescine synthase activity" EXACT [EC:2.1.3.6]
synonym: "putrescine transcarbamylase activity" EXACT [EC:2.1.3.6]
xref: EC:2.1.3.6
xref: KEGG:R01399
xref: MetaCyc:PUTRESCINE-CARBAMOYLTRANSFERASE-RXN
xref: RHEA:21939
is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity

[Term]
id: GO:0050232
name: putrescine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: putrescine + O2 + H2O = 4-aminobutanal + NH3 + H2O2." [EC:1.4.3.10, MetaCyc:PUTRESCINE-OXIDASE-RXN]
subset: gosubset_prok
synonym: "putrescine:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.10]
xref: EC:1.4.3.10
xref: MetaCyc:PUTRESCINE-OXIDASE-RXN
xref: RHEA:18276
is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

[Term]
id: GO:0050233
name: pyranose oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucose + O(2) = 2-dehydro-D-glucose + H(2)O(2)." [EC:1.1.3.10, RHEA:10555]
synonym: "glucose 2-oxidase activity" EXACT [EC:1.1.3.10]
synonym: "pyranose-2-oxidase activity" EXACT [EC:1.1.3.10]
synonym: "pyranose:oxygen 2-oxidoreductase activity" EXACT [EC:1.1.3.10]
xref: EC:1.1.3.10
xref: KEGG:R00302
xref: MetaCyc:PYRANOSE-OXIDASE-RXN
xref: RHEA:10555
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0050234
name: pyrazolylalanine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + H(2)O." [EC:4.2.1.50, RHEA:24515]
synonym: "beta-pyrazolylalaninase activity" EXACT [EC:4.2.1.50]
synonym: "L-serine hydro-lyase (adding pyrazole)" EXACT [EC:4.2.1.50]
synonym: "L-serine hydro-lyase [adding pyrazole; 3-(pyrazol-1-yl)-L-alanine-forming]" RELATED [EC:4.2.1.50]
xref: EC:4.2.1.50
xref: KEGG:R02378
xref: MetaCyc:PYRAZOLYLALANINE-SYNTHASE-RXN
xref: RHEA:24515
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050235
name: pyridoxal 4-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(+) + pyridoxal = 4-pyridoxolactone + H(+) + NADH." [EC:1.1.1.107, RHEA:21339]
synonym: "pyridoxal dehydrogenase activity" EXACT [EC:1.1.1.107]
synonym: "pyridoxal:NAD+ 4-oxidoreductase activity" EXACT [EC:1.1.1.107]
xref: EC:1.1.1.107
xref: KEGG:R01707
xref: MetaCyc:PYRIDOXAL-4-DEHYDROGENASE-RXN
xref: RHEA:21339
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050236
name: pyridoxine:NADP 4-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP(+) + pyridoxine = H(+) + NADPH + pyridoxal." [EC:1.1.1.65, RHEA:16132]
synonym: "PL reductase activity" EXACT [EC:1.1.1.65]
synonym: "pyridoxal reductase activity" EXACT [EC:1.1.1.65]
synonym: "pyridoxin dehydrogenase activity" EXACT [EC:1.1.1.65]
synonym: "pyridoxine dehydrogenase activity" EXACT [EC:1.1.1.65]
synonym: "pyridoxine:NADP 4-oxidoreductase activity" EXACT [EC:1.1.1.65]
synonym: "pyridoxol dehydrogenase activity" EXACT [EC:1.1.1.65]
xref: EC:1.1.1.65
xref: KEGG:R01708
xref: MetaCyc:PYRIDOXINE-4-DEHYDROGENASE-RXN
xref: RHEA:16132
is_a: GO:0004033 ! aldo-keto reductase (NADP) activity

[Term]
id: GO:0050237
name: pyridoxine 4-oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyridoxine + O2 = pyridoxal + H2O2." [EC:1.1.3.12, MetaCyc:PYRIDOXINE-4-OXIDASE-RXN]
synonym: "pyridoxin 4-oxidase activity" EXACT [EC:1.1.3.12]
synonym: "pyridoxine:oxygen 4-oxidoreductase activity" EXACT [EC:1.1.3.12]
synonym: "pyridoxol 4-oxidase activity" EXACT [EC:1.1.3.12]
xref: EC:1.1.3.12
xref: MetaCyc:PYRIDOXINE-4-OXIDASE-RXN
xref: RHEA:15036
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0050238
name: pyridoxine 5-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyridoxine + acceptor = isopyridoxal + reduced acceptor." [EC:1.1.99.9, MetaCyc:PYRIDOXINE-5-DEHYDROGENASE-RXN]
synonym: "pyridoxal-5-dehydrogenase activity" EXACT [EC:1.1.99.9]
synonym: "pyridoxin 5-dehydrogenase activity" EXACT [EC:1.1.99.9]
synonym: "pyridoxine 5'-dehydrogenase activity" EXACT [EC:1.1.99.9]
synonym: "pyridoxine:(acceptor) 5-oxidoreductase activity" EXACT [EC:1.1.99.9]
synonym: "pyridoxine:acceptor 5-oxidoreductase activity" EXACT [EC:1.1.99.9]
synonym: "pyridoxol 5-dehydrogenase activity" EXACT [EC:1.1.99.9]
xref: EC:1.1.99.9
xref: MetaCyc:PYRIDOXINE-5-DEHYDROGENASE-RXN
xref: RHEA:14500
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0050239
name: pyrithiamine deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium bromide + H2O = 1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium bromide + NH3." [EC:3.5.4.20, MetaCyc:PYRITHIAMIN-DEAMINASE-RXN]
synonym: "1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium-bromide aminohydrolase activity" EXACT [EC:3.5.4.20]
xref: EC:3.5.4.20
xref: MetaCyc:PYRITHIAMIN-DEAMINASE-RXN
xref: RHEA:14540
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0050240
name: pyrogallol 1,2-oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: O(2) + pyrogallol = (Z)-5-oxohex-2-enedioate + 2 H(+)." [EC:1.13.11.35, RHEA:19676]
synonym: "1,2,3-trihydroxybenzene:oxygen 1,2-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.35]
synonym: "pyrogallol 1,2-dioxygenase activity" EXACT [EC:1.13.11.35]
xref: EC:1.13.11.35
xref: KEGG:R03246
xref: MetaCyc:PYROGALLOL-12-OXYGENASE-RXN
xref: RHEA:19676
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0050241
name: pyrroline-2-carboxylate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-proline + NAD(P)+ = 1-pyrroline-2-carboxylate + NAD(P)H + H+." [EC:1.5.1.1, MetaCyc:PYRROLINE-2-CARBOXYLATE-REDUCTASE-RXN]
synonym: "delta1-pyrroline-2-carboxylate reductase activity" EXACT [EC:1.5.1.1]
synonym: "L-proline:NAD(P)+ 2-oxidoreductase activity" EXACT [EC:1.5.1.1]
xref: EC:1.5.1.1
xref: MetaCyc:PYRROLINE-2-CARBOXYLATE-REDUCTASE-RXN
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050242
name: pyruvate, phosphate dikinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + phosphate + pyruvate = AMP + diphosphate + 2 H(+) + phosphoenolpyruvate." [EC:2.7.9.1, RHEA:10759]
subset: gosubset_prok
synonym: "ATP:pyruvate, phosphate phosphotransferase activity" EXACT [EC:2.7.9.1]
synonym: "orthophosphate dikinase pyruvate" RELATED [EC:2.7.9.1]
synonym: "PPDK" RELATED [EC:2.7.9.1]
synonym: "pyruvate, Pi dikinase activity" EXACT [EC:2.7.9.1]
synonym: "pyruvate,orthophosphate dikinase activity" EXACT [EC:2.7.9.1]
synonym: "pyruvate,phosphate dikinase activity" EXACT [EC:2.7.9.1]
synonym: "pyruvate-inorganic phosphate dikinase activity" EXACT [EC:2.7.9.1]
synonym: "pyruvate-phosphate dikinase (phosphorylating)" EXACT [EC:2.7.9.1]
synonym: "pyruvate-phosphate dikinase activity" EXACT [EC:2.7.9.1]
synonym: "pyruvate-phosphate ligase activity" EXACT [EC:2.7.9.1]
synonym: "pyruvic-phosphate dikinase activity" EXACT [EC:2.7.9.1]
synonym: "pyruvic-phosphate ligase activity" EXACT [EC:2.7.9.1]
xref: EC:2.7.9.1
xref: KEGG:R00206
xref: MetaCyc:PYRUVATEORTHOPHOSPHATE-DIKINASE-RXN
xref: RHEA:10759
is_a: GO:0016781 ! phosphotransferase activity, paired acceptors

[Term]
id: GO:0050243
name: pyruvate dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: CoA + NADP(+) + pyruvate = acetyl-CoA + CO(2) + NADPH." [EC:1.2.1.51, RHEA:17428]
synonym: "pyruvate:NADP(+) oxidoreductase activity" EXACT [EC:1.2.1.51]
synonym: "pyruvate:NADP+ 2-oxidoreductase (CoA-acetylating)" EXACT [EC:1.2.1.51]
synonym: "pyruvate:NADP+ oxidoreductase activity" EXACT [EC:1.2.1.51]
xref: EC:1.2.1.51
xref: KEGG:R00210
xref: MetaCyc:PYRUVATE-DEHYDROGENASE-NADP%2b-RXN
xref: RHEA:17428
is_a: GO:0034603 ! pyruvate dehydrogenase [NAD(P)+] activity

[Term]
id: GO:0050244
name: pyruvate oxidase (CoA-acetylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: CoA + H(+) + O(2) + pyruvate = acetyl-CoA + CO(2) + H(2)O(2)." [EC:1.2.3.6, RHEA:21915]
synonym: "pyruvate:oxygen 2-oxidoreductase (CoA-acetylating)" EXACT [EC:1.2.3.6]
xref: EC:1.2.3.6
xref: KEGG:R00211
xref: MetaCyc:PYRUVATE-OXIDASE-COA-ACETYLATING-RXN
xref: RHEA:21915
is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor

[Term]
id: GO:0050245
name: quercitrinase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + quercitrin = L-rhamnose + quercetin." [EC:3.2.1.66, RHEA:17468]
synonym: "quercitrin 3-L-rhamnohydrolase activity" EXACT [EC:3.2.1.66]
xref: EC:3.2.1.66
xref: KEGG:R02436
xref: MetaCyc:QUERCITRINASE-RXN
xref: RHEA:17468
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0050246
name: questin monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(+) + NADPH + O(2) + questin = demethylsulochrin + NADP(+)." [EC:1.14.13.43, RHEA:10839]
synonym: "questin oxygenase activity" EXACT [EC:1.14.13.43]
synonym: "questin,NADPH:oxygen oxidoreductase (hydroxylating, anthraquinone-ring-opening)" EXACT [EC:1.14.13.43]
xref: EC:1.14.13.43
xref: KEGG:R02417
xref: MetaCyc:QUESTIN-MONOOXYGENASE-RXN
xref: RHEA:10839
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050247
name: raucaffricine beta-glucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + raucaffricine = D-glucose + vomilenine." [EC:3.2.1.125, RHEA:14560]
synonym: "raucaffricine b-glucosidase activity" EXACT []
synonym: "raucaffricine beta-D-glucohydrolase activity" EXACT [EC:3.2.1.125]
synonym: "raucaffricine beta-D-glucosidase activity" EXACT [EC:3.2.1.125]
synonym: "raucaffricine glucosidase activity" EXACT [EC:3.2.1.125]
xref: EC:3.2.1.125
xref: KEGG:R03703
xref: MetaCyc:RAUCAFFRICINE-BETA-GLUCOSIDASE-RXN
xref: RHEA:14560
is_a: GO:0008422 ! beta-glucosidase activity

[Term]
id: GO:0050248
name: Renilla-luciferin 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: Renilla luciferin + O2 = oxidized Renilla luciferin + CO2 + light." [EC:1.13.12.5, MetaCyc:RENILLA-LUCIFERIN-2-MONOOXYGENASE-RXN]
synonym: "aequorin activity" NARROW [EC:1.13.12.5]
synonym: "luciferase (Renilla luciferin)" EXACT [EC:1.13.12.5]
synonym: "luciferase activity" BROAD [EC:1.13.12.5]
synonym: "Renilla-luciferin:oxygen 2-oxidoreductase (decarboxylating)" EXACT [EC:1.13.12.5]
synonym: "Renilla-type luciferase activity" EXACT [EC:1.13.12.5]
xref: EC:1.13.12.5
xref: MetaCyc:RENILLA-LUCIFERIN-2-MONOOXYGENASE-RXN
xref: RHEA:14768
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)
is_a: GO:0045289 ! luciferin monooxygenase activity

[Term]
id: GO:0050249
name: Renilla-luciferin sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + Renilla luciferin = adenosine 3',5'-diphosphate + H(+) + luciferyl sulfate." [EC:2.8.2.10, RHEA:20484]
synonym: "3'-phosphoadenylyl-sulfate:Renilla luciferin sulfotransferase activity" EXACT [EC:2.8.2.10]
synonym: "luciferin sulfokinase (3'-phosphoadenylyl sulfate:luciferin sulfotransferase)" EXACT [EC:2.8.2.10]
synonym: "luciferin sulfokinase activity" EXACT [EC:2.8.2.10]
synonym: "luciferin sulfotransferase activity" BROAD [EC:2.8.2.10]
synonym: "Renilla-luciferin sulphotransferase activity" EXACT []
xref: EC:2.8.2.10
xref: KEGG:R03138
xref: MetaCyc:RENILLA-LUCIFERIN-SULFOTRANSFERASE-RXN
xref: RHEA:20484
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0050250
name: retinal oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: retinal + O2 + H2O = retinoate + H2O2." [EC:1.2.3.11, MetaCyc:RETINAL-OXIDASE-RXN]
synonym: "retinal:oxygen oxidoreductase activity" EXACT [EC:1.2.3.11]
synonym: "retinene oxidase activity" RELATED [EC:1.2.3.11]
xref: EC:1.2.3.11
xref: MetaCyc:RETINAL-OXIDASE-RXN
xref: RHEA:22523
is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor

[Term]
id: GO:0050251
name: retinol isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: all-trans-retinol = 11-cis-retinol." [EC:5.2.1.7, RHEA:19144]
comment: This term represents a deleted EC activity and is scheduled for obsoletion.
subset: mf_needs_review
synonym: "all-trans-retinol 11-cis-trans-isomerase activity" EXACT [EC:5.2.1.7]
synonym: "all-trans-retinol isomerase activity" EXACT [EC:5.2.1.7]
xref: EC:5.2.1.7
xref: KEGG:R02369
xref: MetaCyc:RETINOL-ISOMERASE-RXN
xref: RHEA:19144
is_a: GO:0016859 ! cis-trans isomerase activity

[Term]
id: GO:0050252
name: retinol O-fatty-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + retinol = CoA + retinyl ester." [EC:2.3.1.76, MetaCyc:RETINOL-O-FATTY-ACYLTRANSFERASE-RXN]
synonym: "acyl-CoA:retinol O-acyltransferase activity" EXACT [EC:2.3.1.76]
synonym: "retinol acyltransferase activity" EXACT [EC:2.3.1.76]
synonym: "retinol fatty-acyltransferase activity" EXACT [EC:2.3.1.76]
xref: EC:2.3.1.76
xref: MetaCyc:RETINOL-O-FATTY-ACYLTRANSFERASE-RXN
xref: RHEA:11491
is_a: GO:0008374 ! O-acyltransferase activity
relationship: part_of GO:0042572 ! retinol metabolic process

[Term]
id: GO:0050253
name: retinyl-palmitate esterase activity
namespace: molecular_function
def: "Catalysis of the reaction: retinyl palmitate + H2O = retinol + palmitate + H+." [MetaCyc:RETINYL-PALMITATE-ESTERASE-RXN, RHEA:21511]
synonym: "retinyl ester hydrolase activity" EXACT [EC:3.1.1.21]
synonym: "retinyl palmitate hydrolase activity" EXACT [EC:3.1.1.21]
synonym: "retinyl palmitate hydrolyase activity" EXACT [EC:3.1.1.21]
synonym: "retinyl-palmitate palmitohydrolase activity" EXACT [EC:3.1.1.21]
xref: EC:3.1.1.-
xref: KEGG:R02368
xref: MetaCyc:RETINYL-PALMITATE-ESTERASE-RXN
xref: Reactome:REACT_25063 "Cleavage of retinyl palmitate by PLB, Homo sapiens"
xref: Reactome:REACT_25240 "Digestion of retinyl palmitate by extracellular PTL:colipase, Homo sapiens"
xref: RHEA:21511
is_a: GO:0052689 ! carboxylic ester hydrolase activity
relationship: part_of GO:0042572 ! retinol metabolic process

[Term]
id: GO:0050254
name: rhodopsin kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN]
synonym: "ATP:rhodopsin phosphotransferase activity" EXACT [EC:2.7.11.14]
synonym: "cone opsin kinase activity" NARROW [EC:2.7.11.14]
synonym: "G-protein-coupled receptor kinase 1 activity" NARROW [EC:2.7.11.14]
synonym: "GPCR kinase 1 activity" NARROW [EC:2.7.11.14]
synonym: "GRK1" RELATED [EC:2.7.11.14]
synonym: "GRK7" RELATED [EC:2.7.11.14]
synonym: "opsin kinase (phosphorylating) activity" EXACT [EC:2.7.11.14]
synonym: "opsin kinase activity" EXACT [EC:2.7.11.14]
synonym: "rhodopsin kinase (phosphorylating) activity" EXACT [EC:2.7.11.14]
synonym: "RK" RELATED [EC:2.7.11.14]
synonym: "STK14" RELATED [EC:2.7.11.14]
xref: EC:2.7.11.14
xref: MetaCyc:2.7.11.14-RXN
is_a: GO:0004672 ! protein kinase activity

[Term]
id: GO:0050255
name: ribitol 2-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-ribitol + NAD(+) = D-ribulose + H(+) + NADH." [EC:1.1.1.56, RHEA:20056]
subset: gosubset_prok
synonym: "adonitol dehydrogenase activity" EXACT [EC:1.1.1.56]
synonym: "ribitol dehydrogenase A (wild type)" RELATED [EC:1.1.1.56]
synonym: "ribitol dehydrogenase B (mutant enzyme with different properties)" RELATED [EC:1.1.1.56]
synonym: "ribitol dehydrogenase D (mutant enzyme with different properties)" RELATED [EC:1.1.1.56]
synonym: "ribitol:NAD+ 2-oxidoreductase activity" EXACT [EC:1.1.1.56]
xref: EC:1.1.1.56
xref: KEGG:R01895
xref: MetaCyc:RIBITOL-2-DEHYDROGENASE-RXN
xref: RHEA:20056
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050256
name: ribitol-5-phosphate 2-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-ribitol 5-phosphate + NAD(P)+ = D-ribulose 5-phosphate + NAD(P)H + H+." [EC:1.1.1.137, MetaCyc:RIBITOL-5-PHOSPHATE-2-DEHYDROGENASE-RXN]
subset: gosubset_prok
synonym: "D-ribitol-5-phosphate:NAD(P)+ 2-oxidoreductase activity" EXACT [EC:1.1.1.137]
synonym: "dehydrogenase, ribitol 5-phosphate" EXACT [EC:1.1.1.137]
xref: EC:1.1.1.137
xref: MetaCyc:RIBITOL-5-PHOSPHATE-2-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050257
name: riboflavin phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate + riboflavin = D-glucose + FMN." [EC:2.7.1.42, RHEA:20412]
synonym: "alpha-D-glucose-1-phosphate:riboflavin 5'-phosphotransferase activity" EXACT [EC:2.7.1.42]
synonym: "D-glucose-1-phosphate:riboflavin 5'-phosphotransferase activity" EXACT [EC:2.7.1.42]
synonym: "G-1-P phosphotransferase activity" EXACT [EC:2.7.1.42]
synonym: "riboflavine phosphotransferase activity" EXACT [EC:2.7.1.42]
xref: EC:2.7.1.42
xref: KEGG:R00550
xref: MetaCyc:RIBOFLAVIN-PHOSPHOTRANSFERASE-RXN
xref: RHEA:20412
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0050258
name: riboflavinase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + H(+) + riboflavin = D-ribitol + lumichrome." [EC:3.5.99.1, RHEA:11411]
synonym: "riboflavin hydrolase activity" EXACT [EC:3.5.99.1]
xref: EC:3.5.99.1
xref: KEGG:R01732
xref: MetaCyc:RIBOFLAVINASE-RXN
xref: RHEA:11411
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

[Term]
id: GO:0050259
name: ribose 1-dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + NADP(+) + ribofuranose = D-ribonate + 2 H(+) + NADPH." [EC:1.1.1.115, RHEA:11679]
synonym: "D-ribose dehydrogenase (NADP+)" EXACT [EC:1.1.1.115]
synonym: "D-ribose:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.115]
synonym: "NADP-pentose-dehydrogenase activity" EXACT [EC:1.1.1.115]
xref: EC:1.1.1.115
xref: KEGG:R01079
xref: MetaCyc:RIBOSE-1-DEHYDROGENASE-NADP+-RXN
xref: RHEA:11679
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050260
name: ribose-5-phosphate-ammonia ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-ribose 5-phosphate + ATP + NH(4)(+) = 5-phospho-D-ribosylamine + ADP + 2 H(+) + phosphate." [EC:6.3.4.7, RHEA:13780]
synonym: "5-phosphoribosylamine synthetase activity" EXACT [EC:6.3.4.7]
synonym: "ammonia-ribose 5-phosphate aminotransferase activity" EXACT [EC:6.3.4.7]
synonym: "ribose 5-phosphate aminotransferase activity" EXACT [EC:6.3.4.7]
synonym: "ribose-5-phosphate:ammonia ligase (ADP-forming)" EXACT [EC:6.3.4.7]
xref: EC:6.3.4.7
xref: KEGG:R01053
xref: MetaCyc:RIBOSE-5-PHOSPHATE--AMMONIA-LIGASE-RXN
xref: RHEA:13780
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0050261
name: ribose isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: ribofuranose = D-ribulose." [EC:5.3.1.20, RHEA:20799]
synonym: "D-ribose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.20]
synonym: "D-ribose isomerase activity" EXACT [EC:5.3.1.20]
synonym: "D-ribose ketol-isomerase activity" EXACT [EC:5.3.1.20]
xref: EC:5.3.1.20
xref: KEGG:R01081
xref: MetaCyc:RIBOSE-ISOMERASE-RXN
xref: RHEA:20799
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0050262
name: ribosylnicotinamide kinase activity
namespace: molecular_function
alt_id: GO:0000816
def: "Catalysis of the reaction: N-ribosylnicotinamide + ATP = ADP + 2 H(+) + nicotinamide mononucleotide." [EC:2.7.1.22, RHEA:14020]
synonym: "ATP:N-ribosylnicotinamide 5'-phosphotransferase activity" EXACT [EC:2.7.1.22]
synonym: "nicotinamide riboside kinase activity" EXACT [PMID:15137942]
synonym: "ribosylnicotinamide kinase (phosphorylating)" EXACT [EC:2.7.1.22]
xref: EC:2.7.1.22
xref: KEGG:R02324
xref: MetaCyc:RIBOSYLNICOTINAMIDE-KINASE-RXN
xref: RHEA:14020
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0050263
name: ribosylpyrimidine nucleosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: an N-D-ribosylpyrimidine + H2O = D-ribose + a pyrimidine." [EC:3.2.2.8, MetaCyc:RIBOSYLPYRIMIDINE-NUCLEOSIDASE-RXN]
synonym: "N-ribosylpyrimidine nucleosidase activity" EXACT [EC:3.2.2.8]
synonym: "N-ribosylpyrimidine ribohydrolase activity" EXACT [EC:3.2.2.8]
synonym: "nucleoside ribohydrolase activity" BROAD [EC:3.2.2.8]
synonym: "pyrimidine nucleosidase activity" EXACT [EC:3.2.2.8]
synonym: "pyrimidine-nucleoside ribohydrolase activity" EXACT [EC:3.2.2.8]
synonym: "RihB" RELATED [EC:3.2.2.8]
synonym: "YeiK" RELATED [EC:3.2.2.8]
xref: EC:3.2.2.8
xref: MetaCyc:RIBOSYLPYRIMIDINE-NUCLEOSIDASE-RXN
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0050264
name: rifamycin-B oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 H(+) + O(2) + rifamycin B = H(2)O(2) + rifamycin O." [EC:1.10.3.6, RHEA:11295]
synonym: "rifamycin B oxidase activity" EXACT [EC:1.10.3.6]
synonym: "rifamycin-B-oxidase activity" EXACT []
synonym: "rifamycin-B:oxygen oxidoreductase activity" EXACT [EC:1.10.3.6]
xref: EC:1.10.3.6
xref: KEGG:R03736
xref: MetaCyc:RIFAMYCIN-B-OXIDASE-RXN
xref: RHEA:11295
is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor

[Term]
id: GO:0050265
name: RNA uridylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UTP + RNA(n) = diphosphate + RNA(n+1)." [EC:2.7.7.52, MetaCyc:RNA-URIDYLYLTRANSFERASE-RXN]
synonym: "poly(U) polymerase activity" EXACT [GOC:dph, GOC:mah]
synonym: "polynucleotide uridylyltransferase activity" EXACT [GOC:dph, GOC:mah]
synonym: "terminal uridylyltransferase activity" EXACT [EC:2.7.7.52]
synonym: "TUT activity" EXACT [EC:2.7.7.52]
synonym: "UTP:RNA uridylyltransferase activity" EXACT []
xref: EC:2.7.7.52
xref: MetaCyc:RNA-URIDYLYLTRANSFERASE-RXN
is_a: GO:0070569 ! uridylyltransferase activity

[Term]
id: GO:0050266
name: rosmarinate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: caffeoyl-CoA + 3-(3,4-dihydroxyphenyl)lactate = CoA + rosmarinate." [EC:2.3.1.140, MetaCyc:ROSMARINATE-SYNTHASE-RXN]
synonym: "4-coumaroyl-CoA:4-hydroxyphenyllactic acid 4-coumaroyl transferase activity" EXACT [EC:2.3.1.140]
synonym: "caffeoyl-CoA:3-(3,4-dihydroxyphenyl)lactate 2'-O-caffeoyl-transferase activity" EXACT [EC:2.3.1.140]
synonym: "caffeoyl-coenzyme A:3,4-dihydroxyphenyllactic acid caffeoyltransferase activity" EXACT [EC:2.3.1.140]
synonym: "rosmarinic acid synthase activity" EXACT [EC:2.3.1.140]
xref: EC:2.3.1.140
xref: MetaCyc:ROSMARINATE-SYNTHASE-RXN
xref: RHEA:22347
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0050267
name: rubber cis-polyprenylcistransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: poly-cis-polyprenyl diphosphate + isopentenyl diphosphate = diphosphate + a poly-cis-polyprenyl diphosphate longer by one C5 unit." [EC:2.5.1.20, MetaCyc:RUBBER-CIS-POLYPRENYLCISTRANSFERASE-RXN]
synonym: "cis-prenyl transferase activity" EXACT [EC:2.5.1.20]
synonym: "isopentenyl pyrophosphate cis-1,4-polyisoprenyl transferase activity" EXACT [EC:2.5.1.20]
synonym: "poly-cis-polyprenyl-diphosphate:isopentenyl-diphosphate polyprenylcistransferase activity" EXACT [EC:2.5.1.20]
synonym: "rubber allyltransferase activity" EXACT [EC:2.5.1.20]
synonym: "rubber polymerase activity" EXACT [EC:2.5.1.20]
synonym: "rubber prenyltransferase activity" EXACT [EC:2.5.1.20]
synonym: "rubber transferase activity" BROAD [EC:2.5.1.20]
xref: EC:2.5.1.20
xref: MetaCyc:2.5.1.20-RXN
is_a: GO:0002094 ! polyprenyltransferase activity

[Term]
id: GO:0050268
name: coniferyl-alcohol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: coniferyl alcohol + NADP+ = coniferyl aldehyde + NADPH." [EC:1.1.1.194, MetaCyc:RXN-1107]
synonym: "coniferyl-alcohol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.194]
xref: EC:1.1.1.194
xref: MetaCyc:RXN-2602
xref: RHEA:22447
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050269
name: coniferyl-aldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: coniferyl aldehyde + H2O + NAD(P)+ = ferulate + NAD(P)H + H+." [EC:1.2.1.68, MetaCyc:RXN-1241]
subset: gosubset_prok
synonym: "coniferyl aldehyde:NAD(P)+ oxidoreductase activity" EXACT [EC:1.2.1.68]
xref: EC:1.2.1.68
xref: MetaCyc:RXN-1241
is_a: GO:0004030 ! aldehyde dehydrogenase [NAD(P)+] activity

[Term]
id: GO:0050270
name: S-adenosylhomocysteine deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-homocysteine + H(2)O + H(+) = S-inosyl-L-homocysteine + NH(4)(+)." [EC:3.5.4.28, RHEA:20719]
synonym: "adenosylhomocysteine deaminase activity" EXACT [EC:3.5.4.28]
synonym: "S-adenosyl-L-homocysteine aminohydrolase activity" EXACT [EC:3.5.4.28]
xref: EC:3.5.4.28
xref: KEGG:R00193
xref: MetaCyc:S-ADENOSYLHOMOCYSTEINE-DEAMINASE-RXN
xref: RHEA:20719
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0050271
name: S-alkylcysteine lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: an S-alkyl-L-cysteine + H2O = an alkyl thiol + NH3 + pyruvate." [EC:4.4.1.6, MetaCyc:S-ALKYLCYSTEINE-LYASE-RXN]
synonym: "alkyl cysteine lyase activity" EXACT [EC:4.4.1.6]
synonym: "alkylcysteine lyase activity" EXACT [EC:4.4.1.6]
synonym: "S-alkyl-L-cysteinase activity" EXACT [EC:4.4.1.6]
synonym: "S-alkyl-L-cysteine alkylthiol-lyase (deaminating) activity" EXACT [EC:4.4.1.6]
synonym: "S-alkyl-L-cysteine alkylthiol-lyase (deaminating; pyruvate-forming)" EXACT [EC:4.4.1.6]
synonym: "S-alkyl-L-cysteine lyase activity" EXACT [EC:4.4.1.6]
synonym: "S-alkyl-L-cysteine sulfoxide lyase activity" EXACT [EC:4.4.1.6]
synonym: "S-alkylcysteinase activity" EXACT [EC:4.4.1.6]
xref: EC:4.4.1.6
xref: MetaCyc:S-ALKYLCYSTEINE-LYASE-RXN
xref: RHEA:22427
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0050272
name: S-carboxymethylcysteine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-chloro-L-alanine + thioglycolate = S-carboxymethyl-L-cysteine + chloride + H(+)." [EC:4.5.1.5, RHEA:22871]
synonym: "3-chloro-L-alanine chloride-lyase (adding thioglycolate)" EXACT [EC:4.5.1.5]
synonym: "3-chloro-L-alanine chloride-lyase (adding thioglycolate; S-carboxymethyl-L-cysteine-forming)" EXACT [EC:4.5.1.5]
synonym: "S-carboxymethyl-L-cysteine synthase activity" EXACT [EC:4.5.1.5]
xref: EC:4.5.1.5
xref: KEGG:R04003
xref: MetaCyc:S-CARBOXYMETHYLCYSTEINE-SYNTHASE-RXN
xref: RHEA:22871
is_a: GO:0016848 ! carbon-halide lyase activity

[Term]
id: GO:0050273
name: S-succinylglutathione hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-succinylglutathione + H(2)O = glutathione + H(+) + succinate." [EC:3.1.2.13, RHEA:16716]
xref: EC:3.1.2.13
xref: KEGG:R00499
xref: MetaCyc:S-SUCCINYLGLUTATHIONE-HYDROLASE-RXN
xref: RHEA:16716
is_a: GO:0016790 ! thiolester hydrolase activity

[Term]
id: GO:0050274
name: salicyl-alcohol beta-D-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: salicyl alcohol + UDP-D-glucose = H(+) + salicin + UDP." [EC:2.4.1.172, RHEA:11515]
synonym: "salicyl-alcohol b-D-glucosyltransferase activity" EXACT []
synonym: "salicyl-alcohol glucosyltransferase activity" EXACT []
synonym: "UDP-glucose:salicyl-alcohol beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.172]
synonym: "UDPglucose:salicyl alcohol phenyl-glucosyltransferase activity" EXACT [EC:2.4.1.172]
synonym: "UDPglucose:salicyl-alcohol beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.172]
synonym: "uridine diphosphoglucose-salicyl alcohol 2-glucosyltransferase activity" EXACT [EC:2.4.1.172]
xref: EC:2.4.1.172
xref: KEGG:R03558
xref: MetaCyc:SALICYL-ALCOHOL-GLUCOSYLTRANSFERASE-RXN
xref: RHEA:11515
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0050275
name: scopoletin glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: scopoletin + UDP-D-glucose = H(+) + scopolin + UDP." [EC:2.4.1.128, RHEA:20456]
synonym: "SGTase activity" EXACT [EC:2.4.1.128]
synonym: "UDP-glucose:scopoletin O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.128]
synonym: "UDPglucose:scopoletin glucosyltransferase activity" EXACT [EC:2.4.1.128]
synonym: "UDPglucose:scopoletin O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.128]
synonym: "uridine diphosphoglucose-scopoletin glucosyltransferase activity" EXACT [EC:2.4.1.128]
xref: EC:2.4.1.128
xref: KEGG:R03594
xref: MetaCyc:SCOPOLETIN-GLUCOSYLTRANSFERASE-RXN
xref: RHEA:20456
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0050276
name: scyllo-inosamine 4-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-amino-1-deoxy-scyllo-inositol + ATP = 1-amino-1-deoxy-scyllo-inositol 4-phosphate + ADP + 2 H(+)." [EC:2.7.1.65, RHEA:18608]
synonym: "ATP:1-amino-1-deoxy-scyllo-inositol 4-phosphotransferase activity" EXACT [EC:2.7.1.65]
synonym: "ATP:inosamine phosphotransferase activity" EXACT [EC:2.7.1.65]
synonym: "scyllo-inosamine kinase (phosphorylating)" EXACT [EC:2.7.1.65]
synonym: "scyllo-inosamine kinase activity" EXACT []
xref: EC:2.7.1.65
xref: KEGG:R03384
xref: MetaCyc:SCYLLO-INOSAMINE-KINASE-RXN
xref: RHEA:18608
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0050277
name: sedoheptulokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + sedoheptulose = ADP + 2 H(+) + sedoheptulose 7-phosphate." [EC:2.7.1.14, RHEA:23847]
synonym: "ATP:sedoheptulose 7-phosphotransferase activity" EXACT [EC:2.7.1.14]
synonym: "heptulokinase activity" EXACT [EC:2.7.1.14]
synonym: "sedoheptulokinase (phosphorylating)" EXACT [EC:2.7.1.14]
xref: EC:2.7.1.14
xref: KEGG:R01844
xref: MetaCyc:SEDOHEPTULOKINASE-RXN
xref: RHEA:23847
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0050278
name: sedoheptulose-bisphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: sedoheptulose 1,7-bisphosphate + H2O = sedoheptulose 7-phosphate + phosphate." [EC:3.1.3.37, MetaCyc:SEDOHEPTULOSE-BISPHOSPHATASE-RXN]
subset: gosubset_prok
synonym: "SBPase activity" EXACT [EC:3.1.3.37]
synonym: "sedoheptulose 1,7-bisphosphatase activity" EXACT [EC:3.1.3.37]
synonym: "sedoheptulose 1,7-diphosphatase activity" EXACT [EC:3.1.3.37]
synonym: "sedoheptulose 1,7-diphosphate phosphatase activity" EXACT [EC:3.1.3.37]
synonym: "sedoheptulose bisphosphatase activity" EXACT [EC:3.1.3.37]
synonym: "sedoheptulose diphosphatase activity" EXACT [EC:3.1.3.37]
synonym: "sedoheptulose-1,7-bisphosphatase activity" EXACT [EC:3.1.3.37]
synonym: "sedoheptulose-1,7-bisphosphate 1-phosphohydrolase activity" EXACT [EC:3.1.3.37]
xref: EC:3.1.3.37
xref: MetaCyc:SEDOHEPTULOSE-BISPHOSPHATASE-RXN
xref: RHEA:17464
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0050279
name: sepiapterin deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: sepiapterin + H2O = xanthopterin-B2 + NH3." [EC:3.5.4.24, MetaCyc:SEPIAPTERIN-DEAMINASE-RXN]
synonym: "sepiapterin aminohydrolase activity" EXACT [EC:3.5.4.24]
xref: EC:3.5.4.24
xref: MetaCyc:SEPIAPTERIN-DEAMINASE-RXN
xref: RHEA:14028
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0050280
name: sequoyitol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-5-O-methyl-myo-inositol + NAD(+) = 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADH." [EC:1.1.1.143, RHEA:11303]
synonym: "5-O-methyl-myo-inositol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.143]
xref: EC:1.1.1.143
xref: KEGG:R03497
xref: MetaCyc:SEQUOYITOL-DEHYDROGENASE-RXN
xref: RHEA:11303
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050281
name: serine-glyoxylate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-serine + glyoxylate = 3-hydroxypyruvate + glycine." [EC:2.6.1.45, MetaCyc:SERINE--GLYOXYLATE-AMINOTRANSFERASE-RXN]
subset: gosubset_prok
synonym: "L-serine:glyoxylate aminotransferase activity" EXACT [EC:2.6.1.45]
synonym: "serine--glyoxylate aminotransferase activity" EXACT []
synonym: "SGAT activity" EXACT [EC:2.6.1.45]
xref: EC:2.6.1.45
xref: MetaCyc:SERINE--GLYOXYLATE-AMINOTRANSFERASE-RXN
xref: RHEA:19128
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0050282
name: serine 2-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-serine + H2O + NAD+ = 3-hydroxypyruvate + NH3 + NADH." [EC:1.4.1.7, MetaCyc:SERINE-DEHYDROGENASE-RXN]
synonym: "L-serine:NAD oxidoreductase (deaminating) activity" EXACT [EC:1.4.1.7]
synonym: "L-serine:NAD+ 2-oxidoreductase (deaminating)" EXACT [EC:1.4.1.7]
synonym: "serine dehydrogenase activity" EXACT []
xref: EC:1.4.1.7
xref: MetaCyc:SERINE-DEHYDROGENASE-RXN
xref: RHEA:20887
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050283
name: serine-sulfate ammonia-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-serine O-sulfate + H2O = pyruvate + NH3 + sulfate." [EC:4.3.1.10, MetaCyc:SERINE-SULFATE-AMMONIA-LYASE-RXN]
synonym: "(L-SOS)lyase activity" EXACT [EC:4.3.1.10]
synonym: "L-serine-O-sulfate ammonia-lyase (pyruvate-forming)" EXACT [EC:4.3.1.10]
synonym: "serine-sulphate ammonia-lyase activity" EXACT []
xref: EC:4.3.1.10
xref: MetaCyc:SERINE-SULFATE-AMMONIA-LYASE-RXN
xref: RHEA:15608
is_a: GO:0016841 ! ammonia-lyase activity

[Term]
id: GO:0050284
name: sinapate 1-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + sinapate = UDP + 1-sinapoyl-D-glucose." [EC:2.4.1.120, MetaCyc:SINAPATE-1-GLUCOSYLTRANSFERASE-RXN]
synonym: "UDP-glucose:sinapate D-glucosyltransferase activity" EXACT [EC:2.4.1.120]
synonym: "UDPglucose:sinapate D-glucosyltransferase activity" EXACT [EC:2.4.1.120]
synonym: "UDPglucose:sinapic acid glucosyltransferase activity" EXACT [EC:2.4.1.120]
synonym: "uridine 5'-diphosphoglucose-hydroxycinnamic acid acylglucosyltransferase activity" EXACT [EC:2.4.1.120]
synonym: "uridine diphosphoglucose-sinapate glucosyltransferase activity" EXACT [EC:2.4.1.120]
xref: EC:2.4.1.120
xref: MetaCyc:SINAPATE-1-GLUCOSYLTRANSFERASE-RXN
xref: RHEA:13308
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0050285
name: sinapine esterase activity
namespace: molecular_function
def: "Catalysis of the reaction: O-sinapoylcholine + H(2)O = choline + H(+) + sinapate." [EC:3.1.1.49, RHEA:10019]
synonym: "aromatic choline esterase activity" EXACT [EC:3.1.1.49]
synonym: "sinapoylcholine sinapohydrolase activity" EXACT [EC:3.1.1.49]
xref: EC:3.1.1.49
xref: KEGG:R02381
xref: MetaCyc:SINAPINE-ESTERASE-RXN
xref: RHEA:10019
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0050286
name: sorbitol-6-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucitol 6-phosphate + H(2)O = D-glucitol + phosphate." [EC:3.1.3.50, RHEA:24583]
synonym: "sorbitol-6-phosphate phosphatase activity" EXACT [EC:3.1.3.50]
synonym: "sorbitol-6-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.50]
xref: EC:3.1.3.50
xref: KEGG:R02866
xref: MetaCyc:SORBITOL-6-PHOSPHATASE-RXN
xref: RHEA:24583
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0050287
name: sorbose 5-dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: L-sorbose + NADP(+) = 5-dehydro-D-fructose + H(+) + NADPH." [EC:1.1.1.123, RHEA:15004]
synonym: "5-keto-D-fructose reductase activity" EXACT [EC:1.1.1.123]
synonym: "5-ketofructose reductase activity" EXACT [EC:1.1.1.123]
synonym: "L-sorbose:NADP+ 5-oxidoreductase activity" EXACT [EC:1.1.1.123]
synonym: "reduced nicotinamide adenine dinucleotide phosphate-linked reductase activity" EXACT [EC:1.1.1.123]
synonym: "sorbose (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT [EC:1.1.1.123]
xref: EC:1.1.1.123
xref: KEGG:R01694
xref: MetaCyc:SORBOSE-5-DEHYDROGENASE-NADP+-RXN
xref: RHEA:15004
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050288
name: sorbose dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-sorbose + A = 5-dehydro-D-fructose + AH(2)." [EC:1.1.99.12, RHEA:14716]
synonym: "L-sorbose:(acceptor) 5-oxidoreductase activity" EXACT [EC:1.1.99.12]
synonym: "L-sorbose:acceptor 5-oxidoreductase activity" EXACT [EC:1.1.99.12]
xref: EC:1.1.99.12
xref: KEGG:R01696
xref: MetaCyc:SORBOSE-DEHYDROGENASE-RXN
xref: RHEA:14716
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0050289
name: spermidine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: spermidine + acceptor + H2O = 1,3-diaminopropane + 4-aminobutanal + reduced acceptor." [EC:1.5.99.6, MetaCyc:SPERMIDINE-DEHYDROGENASE-RXN]
synonym: "spermidine:(acceptor) oxidoreductase activity" EXACT [EC:1.5.99.6]
synonym: "spermidine:acceptor oxidoreductase activity" EXACT [EC:1.5.99.6]
xref: EC:1.5.99.6
xref: MetaCyc:SPERMIDINE-DEHYDROGENASE-RXN
xref: RHEA:14276
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0050290
name: sphingomyelin phosphodiesterase D activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + sphingomyelin = ceramide 1-phosphate + choline + H(+)." [EC:3.1.4.41, RHEA:20987]
synonym: "sphingomyelin ceramide-phosphohydrolase activity" EXACT [EC:3.1.4.41]
synonym: "sphingomyelinase D" RELATED [EC:3.1.4.41]
xref: EC:3.1.4.41
xref: KEGG:R02542
xref: MetaCyc:SPHINGOMYELIN-PHOSPHODIESTERASE-D-RXN
xref: RHEA:20987
is_a: GO:0004620 ! phospholipase activity
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0050291
name: sphingosine N-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + sphingosine = CoA + N-acylsphingosine." [EC:2.3.1.24, MetaCyc:SPHINGOSINE-N-ACYLTRANSFERASE-RXN, PMID:12069845]
synonym: "acyl-CoA:sphingosine N-acyltransferase activity" EXACT [EC:2.3.1.24]
synonym: "ceramide synthase activity" EXACT []
synonym: "ceramide synthetase activity" EXACT [EC:2.3.1.24]
synonym: "dihydroceramide synthase activity" EXACT []
synonym: "sphingosine acyltransferase activity" EXACT [EC:2.3.1.24]
xref: EC:2.3.1.24
xref: MetaCyc:SPHINGOSINE-N-ACYLTRANSFERASE-RXN
xref: Reactome:REACT_102694 "sphinganine + stearyl-CoA => dihydroceramide + CoASH, Xenopus tropicalis"
xref: Reactome:REACT_103601 "sphinganine + stearyl-CoA => dihydroceramide + CoASH, Caenorhabditis elegans"
xref: Reactome:REACT_108906 "sphinganine + stearyl-CoA => dihydroceramide + CoASH, Gallus gallus"
xref: Reactome:REACT_110873 "sphinganine + stearyl-CoA => dihydroceramide + CoASH, Oryza sativa"
xref: Reactome:REACT_115485 "sphinganine + stearyl-CoA => dihydroceramide + CoASH, Drosophila melanogaster"
xref: Reactome:REACT_116027 "sphinganine + stearyl-CoA => dihydroceramide + CoASH, Gallus gallus"
xref: Reactome:REACT_19234 "sphinganine + stearyl-CoA => dihydroceramide + CoASH, Homo sapiens"
xref: Reactome:REACT_28189 "sphinganine + stearyl-CoA => dihydroceramide + CoASH, Rattus norvegicus"
xref: Reactome:REACT_77268 "sphinganine + stearyl-CoA => dihydroceramide + CoASH, Saccharomyces cerevisiae"
xref: Reactome:REACT_77732 "sphinganine + stearyl-CoA => dihydroceramide + CoASH, Plasmodium falciparum"
xref: Reactome:REACT_78387 "sphinganine + stearyl-CoA => dihydroceramide + CoASH, Canis familiaris"
xref: Reactome:REACT_83505 "sphinganine + stearyl-CoA => dihydroceramide + CoASH, Dictyostelium discoideum"
xref: Reactome:REACT_85311 "sphinganine + stearyl-CoA => dihydroceramide + CoASH, Schizosaccharomyces pombe"
xref: Reactome:REACT_86801 "sphinganine + stearyl-CoA => dihydroceramide + CoASH, Mus musculus"
xref: Reactome:REACT_86924 "sphinganine + stearyl-CoA => dihydroceramide + CoASH, Danio rerio"
xref: Reactome:REACT_88414 "sphinganine + stearyl-CoA => dihydroceramide + CoASH, Sus scrofa"
xref: Reactome:REACT_89801 "sphinganine + stearyl-CoA => dihydroceramide + CoASH, Arabidopsis thaliana"
xref: Reactome:REACT_90561 "sphinganine + stearyl-CoA => dihydroceramide + CoASH, Bos taurus"
xref: Reactome:REACT_92256 "sphinganine + stearyl-CoA => dihydroceramide + CoASH, Taeniopygia guttata"
xref: RHEA:23771
is_a: GO:0016410 ! N-acyltransferase activity

[Term]
id: GO:0050292
name: steroid 9-alpha-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: AH(2) + O(2) + pregna-4,9(11)-diene-3,20-dione = 9,11alpha-epoxypregn-4-ene-3,20-dione + A + H(2)O." [EC:1.14.99.24, RHEA:19560]
synonym: "steroid 9-alpha-hydroxylase activity" EXACT [EC:1.14.99.24]
synonym: "steroid 9a-monooxygenase activity" EXACT []
synonym: "steroid 9alpha-hydroxylase activity" EXACT [EC:1.14.99.24]
synonym: "steroid 9alpha-monooxygenase activity" EXACT [EC:1.14.99.24]
synonym: "steroid,hydrogen-donor:oxygen oxidoreductase (9-epoxidizing)" EXACT [EC:1.14.99.24]
xref: EC:1.14.99.24
xref: KEGG:R04392
xref: MetaCyc:STEROID-9-ALPHA-MONOOXYGENASE-RXN
xref: RHEA:19560
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0050293
name: steroid-lactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + testololactone = H(+) + testolate." [EC:3.1.1.37, RHEA:13724]
synonym: "testololactone lactonohydrolase activity" EXACT [EC:3.1.1.37]
xref: EC:3.1.1.37
xref: KEGG:R03641
xref: MetaCyc:STEROID-LACTONASE-RXN
xref: RHEA:13724
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0050294
name: steroid sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenolic steroid = adenosine 3',5'-bisphosphate + steroid O-sulfate." [EC:2.8.2.15, MetaCyc:STEROID-SULFOTRANSFERASE-RXN]
subset: goslim_chembl
synonym: "3'-phosphoadenylyl-sulfate:phenolic-steroid sulfotransferase activity" EXACT [EC:2.8.2.15]
synonym: "steroid alcohol sulfotransferase" BROAD [EC:2.8.2.15]
synonym: "steroid sulphotransferase activity" EXACT []
xref: EC:2.8.2.15
xref: MetaCyc:STEROID-SULFOTRANSFERASE-RXN
xref: Reactome:REACT_100713 "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP, Xenopus tropicalis"
xref: Reactome:REACT_101023 "pregnenolone + PAPS => pregnenolone sulfate + PAP, Xenopus tropicalis"
xref: Reactome:REACT_101639 "pregnenolone + PAPS => pregnenolone sulfate + PAP, Canis familiaris"
xref: Reactome:REACT_102701 "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP, Gallus gallus"
xref: Reactome:REACT_104351 "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP, Danio rerio"
xref: Reactome:REACT_106171 "pregnenolone + PAPS => pregnenolone sulfate + PAP, Bos taurus"
xref: Reactome:REACT_107395 "pregnenolone + PAPS => pregnenolone sulfate + PAP, Gallus gallus"
xref: Reactome:REACT_110277 "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP, Rattus norvegicus"
xref: Reactome:REACT_112914 "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP, Danio rerio"
xref: Reactome:REACT_115144 "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP, Gallus gallus"
xref: Reactome:REACT_29849 "pregnenolone + PAPS => pregnenolone sulfate + PAP, Taeniopygia guttata"
xref: Reactome:REACT_30410 "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP, Taeniopygia guttata"
xref: Reactome:REACT_6805 "pregnenolone + PAPS => pregnenolone sulfate + PAP, Homo sapiens"
xref: Reactome:REACT_6949 "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP, Homo sapiens"
xref: Reactome:REACT_6969 "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP, Homo sapiens"
xref: Reactome:REACT_79278 "pregnenolone + PAPS => pregnenolone sulfate + PAP, Rattus norvegicus"
xref: Reactome:REACT_80906 "pregnenolone + PAPS => pregnenolone sulfate + PAP, Mus musculus"
xref: Reactome:REACT_81388 "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP, Rattus norvegicus"
xref: Reactome:REACT_85290 "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP, Canis familiaris"
xref: Reactome:REACT_85350 "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP, Taeniopygia guttata"
xref: Reactome:REACT_85457 "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP, Mus musculus"
xref: Reactome:REACT_87765 "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP, Canis familiaris"
xref: Reactome:REACT_89252 "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP, Bos taurus"
xref: Reactome:REACT_93059 "pregnenolone + PAPS => pregnenolone sulfate + PAP, Danio rerio"
xref: Reactome:REACT_97439 "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP, Mus musculus"
xref: Reactome:REACT_98750 "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP, Xenopus tropicalis"
xref: Reactome:REACT_99329 "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP, Bos taurus"
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0050295
name: steryl-beta-glucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: cholesteryl-beta-D-glucoside + H(2)O = D-glucose + cholesterol." [EC:3.2.1.104, RHEA:11959]
synonym: "cholesteryl-beta-D-glucoside glucohydrolase activity" EXACT [EC:3.2.1.104]
synonym: "steryl-b-glucosidase activity" EXACT []
xref: EC:3.2.1.104
xref: KEGG:R01460
xref: MetaCyc:STERYL-BETA-GLUCOSIDASE-RXN
xref: RHEA:11959
is_a: GO:0008422 ! beta-glucosidase activity

[Term]
id: GO:0050296
name: stipitatonate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + stipitatonate = CO(2) + H(+) + stipitatate." [EC:4.1.1.60, RHEA:13888]
synonym: "stipitatonate carboxy-lyase (decyclizing)" EXACT [EC:4.1.1.60]
synonym: "stipitatonate carboxy-lyase (decyclizing, stipitatate-forming)" EXACT [EC:4.1.1.60]
xref: EC:4.1.1.60
xref: KEGG:R03739
xref: MetaCyc:STIPITATONATE-DECARBOXYLASE-RXN
xref: RHEA:13888
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050297
name: stizolobate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,4-dihydroxy-L-phenylalanine + O2 = 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde." [EC:1.13.11.29, MetaCyc:STIZOLOBATE-SYNTHASE-RXN]
synonym: "3,4-dihydroxy-L-phenylalanine:oxygen 4,5-oxidoreductase (recyclizing)" EXACT [EC:1.13.11.29]
xref: EC:1.13.11.29
xref: MetaCyc:STIZOLOBATE-SYNTHASE-RXN
xref: RHEA:21223
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0050298
name: stizolobinate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,4-dihydroxy-L-phenylalanine + O2 = 5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde." [EC:1.13.11.30, MetaCyc:STIZOLOBINATE-SYNTHASE-RXN]
synonym: "3,4-dihydroxy-L-phenylalanine:oxygen 2,3-oxidoreductase (recyclizing)" EXACT [EC:1.13.11.30]
xref: EC:1.13.11.30
xref: MetaCyc:STIZOLOBINATE-SYNTHASE-RXN
xref: RHEA:18468
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0050299
name: streptomycin 3''-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + streptomycin = ADP + 2 H(+) + streptomycin 3''-phosphate." [EC:2.7.1.87, RHEA:18380]
subset: gosubset_prok
synonym: "ATP:streptomycin 3''-phosphotransferase activity" EXACT [EC:2.7.1.87]
synonym: "streptomycin 3''-kinase (phosphorylating)" EXACT [EC:2.7.1.87]
synonym: "streptomycin 3''-phosphotransferase activity" EXACT [EC:2.7.1.87]
xref: EC:2.7.1.87
xref: KEGG:R02227
xref: MetaCyc:STREPTOMYCIN-3-KINASE-RXN
xref: RHEA:18380
is_a: GO:0034071 ! aminoglycoside phosphotransferase activity

[Term]
id: GO:0050300
name: aminoglycoside 6-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + streptomycin = ADP + 2 H(+) + streptomycin 6-phosphate." [EC:2.7.1.72, RHEA:22271]
subset: gosubset_prok
synonym: "APH(6) activity" EXACT [EC:2.7.1.72]
synonym: "ATP:streptomycin 6-phosphotransferase activity" NARROW [EC:2.7.1.72]
synonym: "SM 6-kinase activity" NARROW [EC:2.7.1.72]
synonym: "streptidine kinase (phosphorylating)" NARROW [EC:2.7.1.72]
synonym: "streptidine kinase activity" NARROW [EC:2.7.1.72]
synonym: "streptomycin 6-kinase (phosphorylating)" NARROW [EC:2.7.1.72]
synonym: "streptomycin 6-kinase activity" NARROW []
synonym: "streptomycin 6-O-phosphotransferase activity" NARROW [EC:2.7.1.72]
synonym: "streptomycin 6-phosphotransferase activity" NARROW [EC:2.7.1.72]
xref: EC:2.7.1.72
xref: KEGG:R02225
xref: MetaCyc:STREPTOMYCIN-6-KINASE-RXN
xref: RHEA:22271
is_a: GO:0034071 ! aminoglycoside phosphotransferase activity

[Term]
id: GO:0050301
name: streptomycin-6-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + streptomycin 6-phosphate = phosphate + streptomycin." [EC:3.1.3.39, RHEA:10691]
subset: gosubset_prok
synonym: "streptomycin 6-phosphate phosphatase activity" EXACT [EC:3.1.3.39]
synonym: "streptomycin 6-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.39]
synonym: "streptomycin-6-P phosphohydrolase activity" EXACT [EC:3.1.3.39]
synonym: "streptomycin-6-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.39]
xref: EC:3.1.3.39
xref: KEGG:R02228
xref: MetaCyc:STREPTOMYCIN-6-PHOSPHATASE-RXN
xref: RHEA:10691
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0050302
name: indole-3-acetaldehyde oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: (indol-3-yl)acetaldehyde + H(2)O + O(2) = (indol-3-yl)acetate + H(2)O(2) + H(+)." [EC:1.2.3.7, RHEA:16280]
synonym: "(indol-3-yl)acetaldehyde:oxygen oxidoreductase activity" EXACT [EC:1.2.3.7]
synonym: "AO1" RELATED [EC:1.2.3.7]
synonym: "IAA oxidase activity" EXACT [EC:1.2.3.7]
synonym: "IAAld oxidase activity" EXACT [EC:1.2.3.7]
synonym: "indole-3-acetaldehyde:oxygen oxidoreductase activity" EXACT [EC:1.2.3.7]
synonym: "indoleacetaldehyde oxidase activity" EXACT [EC:1.2.3.7]
xref: EC:1.2.3.7
xref: KEGG:R02681
xref: MetaCyc:INDOLE-3-ACETALDEHYDE-OXIDASE-RXN
xref: RHEA:16280
is_a: GO:0018488 ! aryl-aldehyde oxidase activity

[Term]
id: GO:0050303
name: lysine 6-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + NAD+ + L-lysine = NH3 + NADH + allysine." [EC:1.4.1.18, MetaCyc:LYSINE-6-DEHYDROGENASE-RXN]
synonym: "L-lysine 6-dehydrogenase activity" EXACT [EC:1.4.1.18]
synonym: "L-lysine epsilon-dehydrogenase activity" EXACT [EC:1.4.1.18]
synonym: "L-lysine:NAD+ 6-oxidoreductase (deaminating)" EXACT [EC:1.4.1.18]
synonym: "LysDH activity" EXACT [EC:1.4.1.18]
xref: EC:1.4.1.18
xref: MetaCyc:LYSINE-6-DEHYDROGENASE-RXN
xref: MetaCyc:PWY-5314
xref: RHEA:25125
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050304
name: nitrous-oxide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + 2 cytochrome c + nitrogen = 2 reduced cytochrome c + nitrous oxide." [EC:1.7.2.4, MetaCyc:RXN-12130]
synonym: "N2O reductase activity" EXACT [EC:1.7.2.4]
synonym: "nitrogen:(acceptor) oxidoreductase (N2O-forming)" EXACT [EC:1.7.2.4]
synonym: "nitrogen:acceptor oxidoreductase (N2O-forming)" EXACT [EC:1.7.2.4]
synonym: "nitrous oxide reductase activity" EXACT [EC:1.7.2.4]
xref: EC:1.7.2.4
xref: KEGG:R02804
xref: MetaCyc:RXN-12130
is_a: GO:0016662 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor

[Term]
id: GO:0050305
name: strombine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-(carboxymethyl)-D-alanine + H(2)O + NAD(+) = glycine + H(+) + NADH + pyruvate." [EC:1.5.1.22, RHEA:14064]
synonym: "N-(carboxymethyl)-D-alanine: NAD+ oxidoreductase activity" EXACT [EC:1.5.1.22]
synonym: "N-(carboxymethyl)-D-alanine:NAD+ oxidoreductase (glycine-forming)" EXACT [EC:1.5.1.22]
synonym: "strombine[N-(carboxymethyl)-D-alanine]dehydrogenase activity" EXACT [EC:1.5.1.22]
xref: EC:1.5.1.22
xref: KEGG:R00368
xref: MetaCyc:STROMBINE-DEHYDROGENASE-RXN
xref: RHEA:14064
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050306
name: sucrose 1F-fructosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 sucrose = D-glucose + 1F-beta-D-fructosylsucrose." [EC:2.4.1.99, MetaCyc:SUCROSE-1F-FRUCTOSYLTRANSFERASE-RXN]
synonym: "SST activity" EXACT [EC:2.4.1.99]
synonym: "sucrose 1(F)-fructosyltransferase activity" EXACT [EC:2.4.1.99]
synonym: "sucrose-sucrose 1-fructosyltransferase activity" EXACT [EC:2.4.1.99]
synonym: "sucrose:sucrose 1'-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.99]
synonym: "sucrose:sucrose 1(F)-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.99]
synonym: "sucrose:sucrose 1-fructosyltransferase activity" EXACT [EC:2.4.1.99]
synonym: "sucrose:sucrose 1F-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.99]
synonym: "sucrose:sucrose fructosyltransferase activity" EXACT [EC:2.4.1.99]
xref: EC:2.4.1.99
xref: MetaCyc:SUCROSE-1F-FRUCTOSYLTRANSFERASE-RXN
xref: RHEA:23315
is_a: GO:0050738 ! fructosyltransferase activity

[Term]
id: GO:0050307
name: sucrose-phosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: sucrose 6F-phosphate + H2O = sucrose + phosphate." [EC:3.1.3.24, MetaCyc:SUCROSE-PHOSPHATASE-RXN]
subset: gosubset_prok
synonym: "sucrose 6-phosphate hydrolase activity" EXACT [EC:3.1.3.24]
synonym: "sucrose-6F-phosphate phosphohydrolase activity" EXACT systematic_synonym [EC:3.1.3.24]
synonym: "sucrose-phosphate hydrolase activity" EXACT [EC:3.1.3.24]
synonym: "sucrose-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.24]
xref: EC:3.1.3.24
xref: KEGG:R00805
xref: KEGG:R06211
xref: MetaCyc:SUCROSE-PHOSPHATASE-RXN
xref: RHEA:19292
is_a: GO:0050308 ! sugar-phosphatase activity

[Term]
id: GO:0050308
name: sugar-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: sugar phosphate + H2O = sugar + phosphate." [EC:3.1.3.23, MetaCyc:SUGAR-PHOSPHATASE-RXN]
synonym: "sugar-phosphate phosphatase activity" EXACT []
synonym: "sugar-phosphate phosphohydrolase activity" EXACT systematic_synonym [EC:3.1.3.23]
xref: EC:3.1.3.23
xref: KEGG:R00804
xref: MetaCyc:SUGAR-PHOSPHATASE-RXN
is_a: GO:0019203 ! carbohydrate phosphatase activity

[Term]
id: GO:0050309
name: sugar-terminal-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + sugar phosphorylated on the terminal carbon = a sugar + phosphate." [EC:3.1.3.58, MetaCyc:SUGAR-TERMINAL-PHOSPHATASE-RXN]
synonym: "sugar-omega-phosphate phosphohydrolase activity" EXACT systematic_synonym [EC:3.1.3.58]
synonym: "xylitol-5-phosphatase activity" NARROW [EC:3.1.3.58]
xref: EC:3.1.3.58
is_a: GO:0050308 ! sugar-phosphatase activity

[Term]
id: GO:0050310
name: sulfite dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: sulfite + 2 ferricytochrome c + H2O = sulfate + 2 ferrocytochrome c." [EC:1.8.2.1, MetaCyc:SULFITE-DEHYDROGENASE-RXN]
subset: gosubset_prok
synonym: "sulfite cytochrome c reductase activity" EXACT [EC:1.8.2.1]
synonym: "sulfite-cytochrome c oxidoreductase activity" EXACT [EC:1.8.2.1]
synonym: "sulfite:ferricytochrome-c oxidoreductase activity" EXACT [EC:1.8.2.1]
synonym: "sulphite dehydrogenase activity" EXACT []
xref: EC:1.8.2.1
xref: MetaCyc:SULFITE-DEHYDROGENASE-RXN
is_a: GO:0016669 ! oxidoreductase activity, acting on a sulfur group of donors, cytochrome as acceptor

[Term]
id: GO:0050311
name: sulfite reductase (ferredoxin) activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrogen sulfide + 3 oxidized ferredoxin + 3 H2O = sulfite + 3 reduced ferredoxin." [EC:1.8.7.1, MetaCyc:SULFITE-REDUCTASE-FERREDOXIN-RXN]
subset: gosubset_prok
synonym: "ferredoxin-sulfite reductase activity" EXACT [EC:1.8.7.1]
synonym: "hydrogen-sulfide:ferredoxin oxidoreductase activity" EXACT [EC:1.8.7.1]
synonym: "sulphite reductase (ferredoxin) activity" EXACT []
xref: EC:1.8.7.1
xref: MetaCyc:SULFITE-REDUCTASE-FERREDOXIN-RXN
xref: Reactome:REACT_27285 "sulfite is reduced to sulfide, Mycobacterium tuberculosis"
is_a: GO:0016673 ! oxidoreductase activity, acting on a sulfur group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0050312
name: sulfoacetaldehyde lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-sulfoacetaldehyde + H2O = acetate + sulfite." [EC:4.4.1.12, MetaCyc:SULFOACETALDEHYDE-LYASE-RXN]
comment: Note that EC:4.4.1.12 was deleted from EC as the reaction is performed by sulfoacetaldehyde acetyltransferase (EC:2.3.3.15).
synonym: "sulphoacetaldehyde lyase activity" EXACT []
xref: EC:4.4.1.-
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0050313
name: sulfur dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: sulfur + O2 + H2O = sulfite." [EC:1.13.11.18, MetaCyc:SULFUR-DIOXYGENASE-RXN]
synonym: "S-sulfanylglutathione:oxygen oxidoreductase activity" EXACT [EC:1.13.11.18]
synonym: "sulfur oxygenase activity" EXACT [EC:1.13.11.18]
synonym: "sulfur:oxygen oxidoreductase activity" EXACT [EC:1.13.11.18]
synonym: "sulphur dioxygenase activity" EXACT []
xref: EC:1.13.11.18
xref: MetaCyc:FESGSHTHIO-RXN
xref: Reactome:REACT_115730 "Persulfide sulfur is dioxygenated, Homo sapiens"
xref: RHEA:24652
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0050314
name: sym-norspermidine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,3-diaminopropane + S-adenosylmethioninamine = S-methyl-5'-thioadenosine + bis(3-aminopropyl)amine + H(+)." [EC:2.5.1.23, RHEA:23247]
synonym: "S-adenosylmethioninamine:propane-1,3-diamine 3-aminopropyltransferase activity" EXACT [EC:2.5.1.23]
xref: EC:2.5.1.23
xref: KEGG:R03271
xref: MetaCyc:SYM-NORSPERMIDINE-SYNTHASE-RXN
xref: RHEA:23247
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0050315
name: synephrine dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: synephrine = (4-hydroxyphenyl)acetaldehyde + methylammonium." [EC:4.2.1.88, RHEA:17516]
synonym: "1-(4-hydroxyphenyl)-2-(methylamino)ethanol hydro-lyase (methylamine-forming)" EXACT [EC:4.2.1.88]
xref: EC:4.2.1.88
xref: KEGG:R03359
xref: MetaCyc:SYNEPHRINE-DEHYDRATASE-RXN
xref: RHEA:17516
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050316
name: T2-induced deoxynucleotide kinase activity
namespace: molecular_function
def: "Catalysis of the reactions: ATP + dGMP = ADP + dGDP, and ATP + dTMP = ADP + dTDP." [EC:2.7.4.12, MetaCyc:T2-INDUCED-DEOXYNUCLEOTIDE-KINASE-RXN]
synonym: "ATP:(d)NMP phosphotransferase activity" EXACT [EC:2.7.4.12]
xref: EC:2.7.4.12
xref: MetaCyc:GMKALT-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor

[Term]
id: GO:0050317
name: tagatose kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-tagatose + ATP = D-tagatose 6-phosphate + ADP + 2 H(+)." [EC:2.7.1.101, RHEA:15516]
synonym: "ATP:D-tagatose 6-phosphotransferase activity" EXACT [EC:2.7.1.101]
synonym: "D-tagatose 6-phosphate kinase activity" EXACT [EC:2.7.1.101]
synonym: "tagatose 6-phosphate kinase (phosphorylating)" EXACT [EC:2.7.1.101]
xref: EC:2.7.1.101
xref: KEGG:R02927
xref: MetaCyc:TAGATOSE-KINASE-RXN
xref: RHEA:15516
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0050318
name: tannase activity
namespace: molecular_function
def: "Catalysis of the reaction: digallate + H(2)O = 2 gallate + H(+)." [EC:3.1.1.20, RHEA:16368]
synonym: "tannase S" RELATED [EC:3.1.1.20]
synonym: "tannin acetylhydrolase activity" EXACT [EC:3.1.1.20]
synonym: "tannin acylhydrolase activity" EXACT [EC:3.1.1.20]
xref: EC:3.1.1.20
xref: KEGG:R00053
xref: MetaCyc:TANNASE-RXN
xref: RHEA:16368
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0050319
name: tartrate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tartrate + H(+) = D-glycerate + CO(2)." [EC:4.1.1.73, RHEA:13320]
synonym: "(R,R)-tartrate carboxy-lyase (D-glycerate-forming)" EXACT [EC:4.1.1.73]
synonym: "(R,R)-tartrate carboxy-lyase activity" EXACT [EC:4.1.1.73]
xref: EC:4.1.1.73
xref: KEGG:R01751
xref: MetaCyc:TARTRATE-DECARBOXYLASE-RXN
xref: RHEA:13320
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050320
name: tartrate epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tartrate = (2R,3S)-tartrate." [EC:5.1.2.5, RHEA:22215]
synonym: "tartaric racemase activity" EXACT [EC:5.1.2.5]
xref: EC:5.1.2.5
xref: KEGG:R02546
xref: MetaCyc:TARTRATE-EPIMERASE-RXN
xref: RHEA:22215
is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives

[Term]
id: GO:0050321
name: tau-protein kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein." [EC:2.7.11.26, MetaCyc:TAU-PROTEIN-KINASE-RXN]
synonym: "[Tau protein] kinase activity" EXACT []
synonym: "ATP:tau-protein O-phosphotransferase activity" BROAD [EC:2.7.11.26]
synonym: "brain protein kinase PK40erk activity" NARROW [EC:2.7.11.26]
synonym: "cdk5/p20" RELATED [EC:2.7.11.26]
synonym: "CDK5/p23" RELATED [EC:2.7.11.26]
synonym: "glycogen synthase kinase-3beta activity" EXACT [EC:2.7.11.26]
synonym: "GSK" RELATED [EC:2.7.11.26]
synonym: "protein tau kinase activity" EXACT [EC:2.7.11.26]
synonym: "STK31" RELATED [EC:2.7.11.26]
synonym: "tau kinase activity" EXACT [EC:2.7.11.26]
synonym: "tau protein kinase activity" EXACT [EC:2.7.11.26]
synonym: "tau-protein kinase I activity" NARROW [EC:2.7.11.26]
synonym: "tau-protein kinase II activity" NARROW [EC:2.7.11.26]
synonym: "tau-tubulin kinase activity" NARROW [EC:2.7.11.26]
synonym: "TPK" RELATED [EC:2.7.11.26]
synonym: "TPK I" RELATED [EC:2.7.11.26]
synonym: "TPK II" RELATED [EC:2.7.11.26]
synonym: "TTK" RELATED [EC:2.7.11.26]
xref: EC:2.7.11.26
xref: MetaCyc:TAU-PROTEIN-KINASE-RXN
is_a: GO:0004672 ! protein kinase activity

[Term]
id: GO:0050322
name: taurine-2-oxoglutarate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: taurine + 2-oxoglutarate = sulfoacetaldehyde + L-glutamate." [EC:2.6.1.55, MetaCyc:RXN-2301]
synonym: "taurine aminotransferase activity" EXACT []
synonym: "taurine transaminase activity" EXACT []
synonym: "taurine--alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.55]
synonym: "taurine--glutamate transaminase activity" EXACT [EC:2.6.1.55]
synonym: "taurine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.55]
xref: EC:2.6.1.55
xref: MetaCyc:RXN-2301
xref: RHEA:16356
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0050323
name: taurine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: A + H(2)O + taurine = AH(2) + NH(4)(+) + sulfoacetaldehyde." [EC:1.4.99.2, RHEA:18712]
subset: gosubset_prok
synonym: "taurine:(acceptor) oxidoreductase (deaminating)" EXACT [EC:1.4.99.2]
synonym: "taurine:acceptor oxidoreductase (deaminating)" EXACT [EC:1.4.99.2]
xref: EC:1.4.99.2
xref: KEGG:R07167
xref: MetaCyc:TAURINE-DEHYDROGENASE-RXN
xref: RHEA:18712
is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors

[Term]
id: GO:0050324
name: taurocyamine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + taurocyamine = N-phosphotaurocyamine + ADP + 2 H(+)." [EC:2.7.3.4, RHEA:22519]
synonym: "ATP:taurocyamine N-phosphotransferase activity" EXACT [EC:2.7.3.4]
synonym: "ATP:taurocyamine phosphotransferase activity" EXACT [EC:2.7.3.4]
synonym: "taurocyamine phosphotransferase activity" EXACT [EC:2.7.3.4]
xref: EC:2.7.3.4
xref: KEGG:R03785
xref: MetaCyc:TAUROCYAMINE-KINASE-RXN
xref: RHEA:22519
is_a: GO:0016301 ! kinase activity
is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor

[Term]
id: GO:0050325
name: tauropine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + NAD(+) + tauropine = H(+) + NADH + pyruvate + taurine." [EC:1.5.1.23, RHEA:12583]
synonym: "2-N-(D-1-carboxyethyl)taurine:NAD+ oxidoreductase (taurine-forming)" EXACT [EC:1.5.1.23]
synonym: "N2-(D-1-carboxyethyl)taurine:NAD+ oxidoreductase (taurine-forming)" EXACT [EC:1.5.1.23]
xref: EC:1.5.1.23
xref: KEGG:R01683
xref: MetaCyc:TAUROPINE-DEHYDROGENASE-RXN
xref: RHEA:12583
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050326
name: taxifolin 8-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: taxifolin + NAD(P)H + H+ + O2 = 2,3-dihydrogossypetin + NAD(P)+ + H2O." [EC:1.14.13.19, MetaCyc:TAXIFOLIN-8-MONOOXYGENASE-RXN]
synonym: "taxifolin hydroxylase activity" EXACT []
synonym: "taxifolin,NAD(P)H:oxygen oxidoreductase (8-hydroxylating)" EXACT [EC:1.14.13.19]
xref: EC:1.14.13.19
xref: MetaCyc:TAXIFOLIN-8-MONOOXYGENASE-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050328
name: tetrahydroberberine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-tetrahydroberberine + 2 O2 = berberine + 2 H2O2." [EC:1.3.3.8, MetaCyc:TETRAHYDROBERBERINE-OXIDASE-RXN]
synonym: "(S)-tetrahydroberberine:oxygen oxidoreductase activity" EXACT [EC:1.3.3.8]
synonym: "(S)-THB oxidase activity" EXACT [EC:1.3.3.8]
synonym: "THB oxidase activity" EXACT [EC:1.3.3.8]
xref: EC:1.3.3.8
xref: MetaCyc:TETRAHYDROBERBERINE-OXIDASE-RXN
xref: RHEA:13492
is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor

[Term]
id: GO:0050329
name: tetrahydroxypteridine cycloisomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: tetrahydroxypteridine = H(+) + xanthine-8-carboxylate." [EC:5.5.1.3, RHEA:18100]
synonym: "tetrahydroxypteridine lyase (isomerizing)" EXACT [EC:5.5.1.3]
xref: EC:5.5.1.3
xref: KEGG:R04154
xref: MetaCyc:TETRAHYDROXYPTERIDINE-CYCLOISOMERASE-RXN
xref: RHEA:18100
is_a: GO:0016872 ! intramolecular lyase activity

[Term]
id: GO:0050330
name: theanine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N(5)-ethyl-L-glutamine + H(2)O = L-glutamate + ethylamine." [EC:3.5.1.65, RHEA:18016]
synonym: "5-N-ethyl-L-glutamine amidohydrolase activity" EXACT [EC:3.5.1.65]
synonym: "L-theanine amidohydrolase activity" EXACT [EC:3.5.1.65]
synonym: "N5-ethyl-L-glutamine amidohydrolase activity" EXACT [EC:3.5.1.65]
xref: EC:3.5.1.65
xref: KEGG:R02930
xref: MetaCyc:THEANINE-HYDROLASE-RXN
xref: RHEA:18016
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050331
name: thiamine-diphosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + thiamin diphosphate = ADP + thiamin triphosphate." [EC:2.7.4.15, MetaCyc:THIAMIN-DIPHOSPHATE-KINASE-RXN]
synonym: "ATP:thiamin-diphosphate phosphotransferase activity" EXACT [EC:2.7.4.15]
synonym: "ATP:thiamine-diphosphate phosphotransferase activity" EXACT [EC:2.7.4.15]
synonym: "protein bound thiamin diphosphate:ATP phosphoryltransferase activity" EXACT [EC:2.7.4.15]
synonym: "TDP kinase activity" EXACT [EC:2.7.4.15]
synonym: "thiamin diphosphate kinase activity" EXACT [GOC:curators]
synonym: "thiamin diphosphate phosphotransferase activity" EXACT [EC:2.7.4.15]
synonym: "thiamin pyrophosphate kinase activity" EXACT [EC:2.7.4.15]
synonym: "thiamin-diphosphate kinase activity" EXACT []
synonym: "thiamine diphosphate kinase activity" EXACT [EC:2.7.4.15]
xref: EC:2.7.4.15
xref: MetaCyc:THIAMIN-DIPHOSPHATE-KINASE-RXN
xref: Reactome:REACT_25070 "ThDP + ATP <-> ThTP + ADP, Homo sapiens"
xref: RHEA:11243
is_a: GO:0016301 ! kinase activity
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor

[Term]
id: GO:0050332
name: thiamine pyridinylase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyridine + thiamine = 5-(2-hydroxyethyl)-4-methylthiazole + heteropyrithiamine." [EC:2.5.1.2, RHEA:17700]
subset: gosubset_prok
synonym: "pyrimidine transferase activity" EXACT [EC:2.5.1.2]
synonym: "thiamin hydrolase activity" EXACT [EC:2.5.1.2]
synonym: "thiamin pyridinolase activity" EXACT [EC:2.5.1.2]
synonym: "thiamin pyridinylase activity" EXACT [GOC:curators]
synonym: "thiamin:base 2-methyl-4-aminopyrimidine-5-methenyltransferase activity" EXACT [EC:2.5.1.2]
synonym: "thiaminase I activity" NARROW [EC:2.5.1.2]
synonym: "thiamine hydrolase activity" EXACT [EC:2.5.1.2]
synonym: "thiamine pyridinolase activity" EXACT [EC:2.5.1.2]
synonym: "thiamine:base 2-methyl-4-aminopyrimidine-5-methenyltransferase activity" EXACT [EC:2.5.1.2]
xref: EC:2.5.1.2
xref: KEGG:R02863
xref: MetaCyc:THIAMIN-PYRIDINYLASE-RXN
xref: RHEA:17700
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0050333
name: thiamin-triphosphatase activity
namespace: molecular_function
alt_id: GO:0048253
def: "Catalysis of the reaction: H(2)O + thiamine triphosphate = H(+) + phosphate + thiamine diphosphate." [EC:3.6.1.28, RHEA:11747]
synonym: "thiamine-triphosphatase activity" EXACT []
synonym: "thiamine-triphosphate phosphohydrolase activity" EXACT [EC:3.6.1.28]
synonym: "ThTPase activity" EXACT [EC:3.6.1.28]
xref: EC:3.6.1.28
xref: KEGG:R00618
xref: MetaCyc:THIAMIN-TRIPHOSPHATASE-RXN
xref: Reactome:REACT_25137 "Thiamin triphosphate can be hydrolysed back to thiamin diphosphate, Homo sapiens"
xref: RHEA:11747
is_a: GO:0017111 ! nucleoside-triphosphatase activity

[Term]
id: GO:0050334
name: thiaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + thiamine = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H(+)." [EC:3.5.99.2, RHEA:17512]
synonym: "thiaminase II activity" NARROW [EC:3.5.99.2]
xref: EC:3.5.99.2
xref: KEGG:R02133
xref: MetaCyc:THIAMINASE-RXN
xref: RHEA:17512
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

[Term]
id: GO:0050335
name: thiocyanate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzyl isothiocyanate = benzyl thiocyanate." [EC:5.99.1.1, RHEA:10007]
synonym: "benzyl-thiocyanate isomerase activity" EXACT [EC:5.99.1.1]
synonym: "isothiocyanate isomerase activity" EXACT [EC:5.99.1.1]
xref: EC:5.99.1.1
xref: KEGG:R04010
xref: MetaCyc:THIOCYANATE-ISOMERASE-RXN
xref: RHEA:10007
is_a: GO:0016853 ! isomerase activity

[Term]
id: GO:0050336
name: thioethanolamine S-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + cysteamine = S-acetylcysteamine + CoA." [EC:2.3.1.11, RHEA:23283]
synonym: "acetyl-CoA:2-aminoethanethiol S-acetyltransferase activity" EXACT [EC:2.3.1.11]
synonym: "acetyl-CoA:thioethanolamine S-acetyltransferase activity" EXACT [EC:2.3.1.11]
synonym: "thioethanolamine acetyltransferase activity" EXACT [EC:2.3.1.11]
synonym: "thioltransacetylase B activity" EXACT [EC:2.3.1.11]
xref: EC:2.3.1.11
xref: KEGG:R03668
xref: MetaCyc:THIOETHANOLAMINE-S-ACETYLTRANSFERASE-RXN
xref: RHEA:23283
is_a: GO:0016418 ! S-acetyltransferase activity

[Term]
id: GO:0050337
name: thiosulfate-thiol sulfurtransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: thiosulfate + 2 glutathione = sulfite + glutathione disulfide + sulfide." [EC:2.8.1.3, MetaCyc:THIOSULFATE--THIOL-SULFURTRANSFERASE-RXN]
synonym: "glutathione-dependent thiosulfate reductase activity" EXACT [EC:2.8.1.3]
synonym: "sulfane reductase activity" EXACT [EC:2.8.1.3]
synonym: "sulfane sulfurtransferase activity" EXACT [EC:2.8.1.3]
synonym: "thiosulfate:thiol sulfurtransferase activity" EXACT [EC:2.8.1.3]
synonym: "thiosulphate-thiol sulphurtransferase activity" EXACT []
xref: EC:2.8.1.3
xref: MetaCyc:THIOSULFATE--THIOL-SULFURTRANSFERASE-RXN
xref: RHEA:14508
is_a: GO:0016783 ! sulfurtransferase activity

[Term]
id: GO:0050338
name: thiosulfate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 thiosulfate + 2 ferricytochrome c = tetrathionate + 2 ferrocytochrome c." [EC:1.8.2.2, MetaCyc:THIOSULFATE-DEHYDROGENASE-RXN]
synonym: "tetrathionate synthase activity" EXACT [EC:1.8.2.2]
synonym: "thiosulfate oxidase activity" EXACT [EC:1.8.2.2]
synonym: "thiosulfate-acceptor oxidoreductase activity" EXACT [EC:1.8.2.2]
synonym: "thiosulfate-oxidizing enzyme" RELATED [EC:1.8.2.2]
synonym: "thiosulfate:ferricytochrome-c oxidoreductase activity" EXACT [EC:1.8.2.2]
synonym: "thiosulphate dehydrogenase activity" EXACT []
xref: EC:1.8.2.2
xref: MetaCyc:THIOSULFATE-DEHYDROGENASE-RXN
is_a: GO:0016669 ! oxidoreductase activity, acting on a sulfur group of donors, cytochrome as acceptor

[Term]
id: GO:0050339
name: thymidine-triphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: dTTP + H2O = dTDP + phosphate." [EC:3.6.1.39, MetaCyc:THYMIDINE-TRIPHOSPHATASE-RXN]
synonym: "deoxythymidine-5'-triphosphatase activity" EXACT [EC:3.6.1.39]
synonym: "dTTP nucleotidohydrolase activity" EXACT [EC:3.6.1.39]
synonym: "dTTPase activity" EXACT [EC:3.6.1.39]
synonym: "thymidine triphosphate nucleotidohydrolase activity" EXACT [EC:3.6.1.39]
xref: EC:3.6.1.39
xref: MetaCyc:THYMIDINE-TRIPHOSPHATASE-RXN
xref: RHEA:19016
is_a: GO:0017111 ! nucleoside-triphosphatase activity

[Term]
id: GO:0050340
name: thymidylate 5'-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: thymidylate + H2O = thymidine + phosphate." [EC:3.1.3.35, MetaCyc:THYMIDYLATE-5-PHOSPHATASE-RXN]
synonym: "deoxythymidylate 5'-nucleotidase activity" EXACT [EC:3.1.3.35]
synonym: "deoxythymidylate phosphohydrolase activity" EXACT [EC:3.1.3.35]
synonym: "deoxythymidylic 5'-nucleotidase activity" EXACT [EC:3.1.3.35]
synonym: "dTMPase activity" EXACT [EC:3.1.3.35]
synonym: "thymidylate 5' phosphatase activity" EXACT []
synonym: "thymidylate 5'-nucleotidase activity" EXACT [EC:3.1.3.35]
synonym: "thymidylate 5'-phosphohydrolase activity" EXACT [EC:3.1.3.35]
synonym: "thymidylate nucleotidase activity" EXACT [EC:3.1.3.35]
xref: EC:3.1.3.35
xref: MetaCyc:THYMIDYLATE-5-PHOSPHATASE-RXN
xref: RHEA:11083
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0050341
name: thymine dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: thymine + 2-oxoglutarate + O2 = 5-hydroxymethyluracil + succinate + CO2." [EC:1.14.11.6, MetaCyc:THYMINE-DIOXYGENASE-RXN]
synonym: "5-hydroxy-methyluracil dioxygenase activity" EXACT [EC:1.14.11.6]
synonym: "5-hydroxymethyluracil oxygenase activity" EXACT [EC:1.14.11.6]
synonym: "thymine 7-hydroxylase activity" EXACT [EC:1.14.11.6]
synonym: "thymine,2-oxoglutarate dioxygenase activity" EXACT [EC:1.14.11.6]
synonym: "thymine,2-oxoglutarate:oxygen oxidoreductase (7-hydroxylating)" EXACT [EC:1.14.11.6]
xref: EC:1.14.11.6
xref: MetaCyc:THYMINE-DIOXYGENASE-RXN
xref: RHEA:10319
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0050342
name: tocopherol O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + gamma-tocopherol = S-adenosyl-L-homocysteine + alpha-tocopherol." [EC:2.1.1.95, MetaCyc:TOCOPHEROL-O-METHYLTRANSFERASE-RXN]
synonym: "gamma-tocopherol methyltransferase activity" EXACT []
synonym: "S-adenosyl-L-methionine:gamma-tocopherol 5-O-methyltransferase activity" EXACT [EC:2.1.1.95]
xref: EC:2.1.1.95
xref: MetaCyc:TOCOPHEROL-O-METHYLTRANSFERASE-RXN
xref: RHEA:24015
is_a: GO:0008171 ! O-methyltransferase activity

[Term]
id: GO:0050343
name: trans-2-enoyl-CoA reductase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + NAD+ = trans-didehydroacyl-CoA + NADH." [EC:1.3.1.44, MetaCyc:TRANS-2-ENOYL-COA-REDUCTASE-NAD+-RXN]
synonym: "acyl-CoA:NAD+ trans-2-oxidoreductase activity" EXACT [EC:1.3.1.44]
xref: EC:1.3.1.44
xref: MetaCyc:TRANS-2-ENOYL-COA-REDUCTASE-NAD+-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050344
name: trans-cinnamate 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-cinnamate + H(+) + NADPH + O(2) = 2-coumarate + H(2)O + NADP(+)." [EC:1.14.13.14, RHEA:10959]
synonym: "cinnamate 2-hydroxylase activity" EXACT [EC:1.14.13.14]
synonym: "cinnamate 2-monooxygenase activity" EXACT [EC:1.14.13.14]
synonym: "cinnamic 2-hydroxylase activity" EXACT [EC:1.14.13.14]
synonym: "cinnamic acid 2-hydroxylase activity" EXACT [EC:1.14.13.14]
synonym: "trans-cinnamate,NADPH:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.13.14]
synonym: "trans-cinnamic acid 2-hydroxylase activity" EXACT []
xref: EC:1.14.13.14
xref: KEGG:R02254
xref: MetaCyc:TRANS-CINNAMATE-2-MONOOXYGENASE-RXN
xref: RHEA:10959
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050345
name: trans-epoxysuccinate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-2,3-epoxysuccinate + H(2)O = (2R,3S)-tartrate." [EC:3.3.2.4, RHEA:20743]
synonym: "tartrate epoxydase activity" EXACT [EC:3.3.2.4]
synonym: "trans-2,3-epoxysuccinate hydrolase activity" EXACT [EC:3.3.2.4]
synonym: "trans-epoxysuccinate hydratase activity" EXACT [EC:3.3.2.4]
xref: EC:3.3.2.4
xref: KEGG:R02547
xref: MetaCyc:TRANS-EPOXYSUCCINATE-HYDROLASE-RXN
xref: RHEA:20743
is_a: GO:0016803 ! ether hydrolase activity

[Term]
id: GO:0050346
name: trans-L-3-hydroxyproline dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-L-3-hydroxyproline = 1-pyrroline-2-carboxylate + H(2)O + H(+)." [EC:4.2.1.77, RHEA:10323]
synonym: "trans-L-3-hydroxyproline hydro-lyase (Delta1-pyrroline 2-carboxylate-forming)" EXACT [EC:4.2.1.77]
synonym: "trans-L-3-hydroxyproline hydro-lyase activity" EXACT [EC:4.2.1.77]
xref: EC:4.2.1.77
xref: KEGG:R04374
xref: MetaCyc:TRANS-L-3-HYDROXYPROLINE-DEHYDRATASE-RXN
xref: RHEA:10323
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050347
name: trans-octaprenyltranstransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: all-trans-octaprenyl diphosphate + isopentenyl diphosphate = all-trans-nonaprenyl diphosphate + diphosphate." [RHEA:11327]
comment: This term represents a deleted EC activity and is scheduled for obsoletion.
subset: mf_needs_review
synonym: "(E)-octaprenyl-diphosphate:isopentenyl-diphosphate octaprenyltranstransferase activity" EXACT [EC:2.5.1.11]
synonym: "all-trans-nonaprenyl-diphosphate synthase activity" EXACT [EC:2.5.1.11]
synonym: "nonaprenyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.11]
synonym: "polyprenylpyrophosphate synthetase activity" EXACT [EC:2.5.1.11]
synonym: "solanesyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.11]
synonym: "solanesyl-diphosphate synthase activity" EXACT [EC:2.5.1.11]
synonym: "SPP synthase activity" EXACT [EC:2.5.1.11]
synonym: "terpenoidallyltransferase activity" EXACT [EC:2.5.1.11]
synonym: "terpenyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.11]
synonym: "trans-prenyltransferase activity" EXACT [EC:2.5.1.11]
xref: EC:2.5.1.84
xref: EC:2.5.1.85
xref: KEGG:R07267
xref: RHEA:11327
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0050348
name: trehalose O-mycolyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 alpha,alpha'-trehalose 6-mycolate = alpha,alpha'-trehalose 6,6'-bismycolate + alpha,alpha-trehalose." [EC:2.3.1.122, RHEA:23475]
subset: gosubset_prok
synonym: "alpha,alpha'-trehalose 6-monomycolate:alpha,alpha'-trehalose mycolyltransferase activity" EXACT [EC:2.3.1.122]
synonym: "alpha,alpha'-trehalose-6-mycolate:alpha,alpha'-trehalose-6-mycolate 6'-mycolyltransferase activity" EXACT [EC:2.3.1.122]
xref: EC:2.3.1.122
xref: KEGG:R07248
xref: MetaCyc:RXN1G-874
xref: RHEA:23475
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0050349
name: triacetate-lactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + triacetate lactone = triacetate." [EC:3.1.1.38, RHEA:22263]
synonym: "TAL hydrolase activity" EXACT [EC:3.1.1.38]
synonym: "triacetate lactone hydrolase activity" EXACT [EC:3.1.1.38]
synonym: "triacetic acid lactone hydrolase activity" EXACT [EC:3.1.1.38]
synonym: "triacetic lactone hydrolase activity" EXACT [EC:3.1.1.38]
synonym: "triacetolactone lactonohydrolase activity" EXACT [EC:3.1.1.38]
xref: EC:3.1.1.38
xref: KEGG:R03702
xref: MetaCyc:TRIACETATE-LACTONASE-RXN
xref: RHEA:22263
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0050350
name: trihydroxystilbene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + 3,4',5-trihydroxy-stilbene + 4 CO2." [EC:2.3.1.95, MetaCyc:TRIHYDROXYSTILBENE-SYNTHASE-RXN]
synonym: "malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)" BROAD [EC:2.3.1.95]
synonym: "resveratrol synthase activity" EXACT [EC:2.3.1.95]
synonym: "stilbene synthase activity" BROAD [EC:2.3.1.95]
xref: EC:2.3.1.95
xref: MetaCyc:TRIHYDROXYSTILBENE-SYNTHASE-RXN
xref: RHEA:11939
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0050351
name: trimetaphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + trimetaphosphate = 2 H(+) + triphosphate." [EC:3.6.1.2, RHEA:11091]
subset: gosubset_prok
synonym: "inorganic trimetaphosphatase activity" EXACT [EC:3.6.1.2]
synonym: "trimetaphosphate hydrolase activity" EXACT [EC:3.6.1.2]
xref: EC:3.6.1.2
xref: KEGG:R02504
xref: MetaCyc:TRIMETAPHOSPHATASE-RXN
xref: RHEA:11091
is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

[Term]
id: GO:0050352
name: trimethylamine-oxide aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(+) + trimethylamine N-oxide = dimethylamine + formaldehyde." [EC:4.1.2.32, RHEA:20220]
synonym: "trimethylamine N-oxide aldolase activity" EXACT [EC:4.1.2.32]
synonym: "trimethylamine N-oxide demethylase activity" EXACT [EC:4.1.2.32]
synonym: "trimethylamine N-oxide formaldehyde-lyase activity" EXACT [EC:4.1.2.32]
synonym: "trimethylamine-N-oxide formaldehyde-lyase (dimethylamine-forming)" EXACT [EC:4.1.2.32]
synonym: "trimethylamine-N-oxide formaldehyde-lyase activity" EXACT [EC:4.1.2.32]
xref: EC:4.1.2.32
xref: KEGG:R02512
xref: MetaCyc:TRIMETHYLAMINE-OXIDE-ALDOLASE-RXN
xref: RHEA:20220
xref: UM-BBD_reactionID:r1409
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0050353
name: trimethyllysine dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O(2) = 3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO(2) + succinate." [EC:1.14.11.8, RHEA:14184]
synonym: "6-N,6-N,6-N-trimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.11.8]
synonym: "epsilon-trimethyllysine 2-oxoglutarate dioxygenase activity" EXACT [EC:1.14.11.8]
synonym: "N6,N6,N6-trimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.11.8]
synonym: "TML dioxygenase activity" EXACT [EC:1.14.11.8]
synonym: "TML hydroxylase activity" EXACT [EC:1.14.11.8]
synonym: "TML-alpha-ketoglutarate dioxygenase activity" EXACT [EC:1.14.11.8]
synonym: "TMLD activity" EXACT [EC:1.14.11.8]
synonym: "trimethyllysine alpha-ketoglutarate dioxygenase activity" EXACT [EC:1.14.11.8]
synonym: "trimethyllysine,2-oxoglutarate dioxygenase activity" EXACT [EC:1.14.11.8]
xref: EC:1.14.11.8
xref: KEGG:R03451
xref: MetaCyc:TRIMETHYLLYSINE-DIOXYGENASE-RXN
xref: Reactome:REACT_1814 "trimethyllysine + alpha-ketoglutarate + O2 => beta-hydroxy-trimethyllysine + succinate + CO2, Homo sapiens"
xref: Reactome:REACT_32214 "trimethyllysine + alpha-ketoglutarate + O2 => beta-hydroxy-trimethyllysine + succinate + CO2, Caenorhabditis elegans"
xref: Reactome:REACT_32390 "trimethyllysine + alpha-ketoglutarate + O2 => beta-hydroxy-trimethyllysine + succinate + CO2, Sus scrofa"
xref: Reactome:REACT_33145 "trimethyllysine + alpha-ketoglutarate + O2 => beta-hydroxy-trimethyllysine + succinate + CO2, Drosophila melanogaster"
xref: Reactome:REACT_34450 "trimethyllysine + alpha-ketoglutarate + O2 => beta-hydroxy-trimethyllysine + succinate + CO2, Danio rerio"
xref: Reactome:REACT_82844 "trimethyllysine + alpha-ketoglutarate + O2 => beta-hydroxy-trimethyllysine + succinate + CO2, Gallus gallus"
xref: Reactome:REACT_83991 "trimethyllysine + alpha-ketoglutarate + O2 => beta-hydroxy-trimethyllysine + succinate + CO2, Rattus norvegicus"
xref: Reactome:REACT_86984 "trimethyllysine + alpha-ketoglutarate + O2 => beta-hydroxy-trimethyllysine + succinate + CO2, Canis familiaris"
xref: Reactome:REACT_95510 "trimethyllysine + alpha-ketoglutarate + O2 => beta-hydroxy-trimethyllysine + succinate + CO2, Xenopus tropicalis"
xref: Reactome:REACT_96684 "trimethyllysine + alpha-ketoglutarate + O2 => beta-hydroxy-trimethyllysine + succinate + CO2, Taeniopygia guttata"
xref: Reactome:REACT_97817 "trimethyllysine + alpha-ketoglutarate + O2 => beta-hydroxy-trimethyllysine + succinate + CO2, Mus musculus"
xref: Reactome:REACT_97973 "trimethyllysine + alpha-ketoglutarate + O2 => beta-hydroxy-trimethyllysine + succinate + CO2, Bos taurus"
xref: RHEA:14184
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0050354
name: triokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + 2 H(+)." [EC:2.7.1.28, RHEA:13944]
synonym: "ATP:D-glyceraldehyde 3-phosphotransferase activity" EXACT [EC:2.7.1.28]
synonym: "D-triokinase activity" EXACT [EC:2.7.1.28]
synonym: "trio triose kinase (phosphorylating)" EXACT [EC:2.7.1.28]
synonym: "triose kinase activity" EXACT [EC:2.7.1.28]
xref: EC:2.7.1.28
xref: KEGG:R01059
xref: MetaCyc:TRIOKINASE-RXN
xref: Reactome:REACT_21407 "ATP + D-glyceraldehyde => ADP + D-glyceraldehyde 3-phosphate, Cavia porcellus"
xref: Reactome:REACT_52 "ATP + D-glyceraldehyde => ADP + D-glyceraldehyde 3-phosphate, Homo sapiens"
xref: RHEA:13944
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0050355
name: triphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + triphosphate = diphosphate + phosphate." [EC:3.6.1.25, RHEA:14160]
subset: gosubset_prok
synonym: "inorganic triphosphatase activity" EXACT [EC:3.6.1.25]
synonym: "triphosphate phosphohydrolase activity" EXACT [EC:3.6.1.25]
synonym: "tripolyphosphatase activity" EXACT [PMID:24004165]
xref: EC:3.6.1.25
xref: KEGG:R00138
xref: MetaCyc:TRIPHOSPHATASE-RXN
xref: RHEA:14160
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0050356
name: tropine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP(+) + tropine = H(+) + NADPH + tropinone." [EC:1.1.1.206, RHEA:18360]
synonym: "tropine:NADP+ 3alpha-oxidoreductase activity" EXACT [EC:1.1.1.206]
xref: EC:1.1.1.206
xref: KEGG:R02832
xref: MetaCyc:TROPINE-DEHYDROGENASE-RXN
xref: RHEA:18360
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050357
name: tropinesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: atropine + H(2)O = H(+) + tropate + tropine." [EC:3.1.1.10, RHEA:23307]
subset: gosubset_prok
synonym: "atropinase activity" EXACT [EC:3.1.1.10]
synonym: "atropine acylhydrolase activity" EXACT [EC:3.1.1.10]
synonym: "atropine esterase activity" EXACT [EC:3.1.1.10]
synonym: "atropinesterase activity" EXACT [EC:3.1.1.10]
synonym: "tropine esterase activity" EXACT [EC:3.1.1.10]
xref: EC:3.1.1.10
xref: KEGG:R03563
xref: MetaCyc:TROPINESTERASE-RXN
xref: RHEA:23307
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0050358
name: tropinone reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP(+) + pseudotropine = H(+) + NADPH + tropinone." [EC:1.1.1.236, RHEA:24247]
synonym: "pseudotropine forming tropinone reductase activity" EXACT [EC:1.1.1.236]
synonym: "pseudotropine:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.236]
synonym: "tropinone (psi-tropine-forming) reductase activity" EXACT [EC:1.1.1.236]
synonym: "tropinone reductase II activity" RELATED [EC:1.1.1.236]
xref: EC:1.1.1.236
xref: KEGG:R06734
xref: MetaCyc:TROPINONE-REDUCTASE-RXN
xref: RHEA:24247
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050359
name: tropomyosin kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + tropomyosin = ADP + O-phosphotropomyosin." [EC:2.7.11.28, MetaCyc:TROPOMYOSIN-KINASE-RXN]
synonym: "ATP:tropomyosin O-phosphotransferase activity" EXACT [EC:2.7.11.28]
synonym: "STK" RELATED [EC:2.7.11.28]
synonym: "tropomyosin kinase (phosphorylating) activity" EXACT [EC:2.7.11.28]
xref: EC:2.7.11.28
xref: MetaCyc:TROPOMYOSIN-KINASE-RXN
is_a: GO:0004672 ! protein kinase activity

[Term]
id: GO:0050360
name: tryptophan 2'-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tryptophan + O2 = 3-indoleglycolaldehyde + CO2 + NH3." [EC:1.13.99.3, MetaCyc:TRYPTOPHAN-2-DIOXYGENASE-RXN]
synonym: "indole-3-alkane alpha-hydroxylase activity" EXACT [EC:1.13.99.3]
synonym: "indolyl-3-alkan alpha-hydroxylase activity" EXACT [EC:1.13.99.3]
synonym: "L-tryptophan:oxygen 2'-oxidoreductase (side-chain-cleaving)" EXACT [EC:1.13.99.3]
synonym: "tryptophan side chain oxidase activity" EXACT [EC:1.13.99.3]
synonym: "tryptophan side chain oxidase II" RELATED [EC:1.13.99.3]
synonym: "tryptophan side chain oxidase type I" RELATED [EC:1.13.99.3]
synonym: "tryptophan side-chain alpha,beta-oxidase activity" RELATED [EC:1.13.99.3]
synonym: "tryptophan side-chain oxidase activity" RELATED [EC:1.13.99.3]
synonym: "TSO activity" RELATED [EC:1.13.99.3]
synonym: "TSO I" RELATED [EC:1.13.99.3]
synonym: "TSO II" RELATED [EC:1.13.99.3]
xref: EC:1.13.99.3
xref: MetaCyc:TRYPTOPHAN-2-DIOXYGENASE-RXN
xref: RHEA:22623
is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen

[Term]
id: GO:0050361
name: tryptophan 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tryptophan + O(2) = CO(2) + H(2)O + indole-3-acetamide." [EC:1.13.12.3, RHEA:16168]
subset: gosubset_prok
synonym: "L-tryptophan:oxygen 2-oxidoreductase (decarboxylating)" EXACT [EC:1.13.12.3]
xref: EC:1.13.12.3
xref: KEGG:R00679
xref: MetaCyc:TRYPTOPHAN-2-MONOOXYGENASE-RXN
xref: RHEA:16168
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)

[Term]
id: GO:0050362
name: L-tryptophan:2-oxoglutarate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tryptophan + 2-oxoglutarate = indolepyruvate + L-glutamate." [EC:2.6.1.27, MetaCyc:TRYPTOPHAN-AMINOTRANSFERASE-RXN]
synonym: "5-hydroxytryptophan-ketoglutaric transaminase activity" RELATED [EC:2.6.1.27]
synonym: "hydroxytryptophan aminotransferase activity" RELATED [EC:2.6.1.27]
synonym: "L-phenylalanine-2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.27]
synonym: "L-tryptophan aminotransferase activity" BROAD [EC:2.6.1.27]
synonym: "L-tryptophan transaminase activity" BROAD [EC:2.6.1.27]
synonym: "tryptophan aminotransferase activity" EXACT []
synonym: "tryptophan transaminase activity" BROAD [EC:2.6.1.27]
xref: EC:2.6.1.27
xref: MetaCyc:TRYPTOPHAN-AMINOTRANSFERASE-RXN
xref: RHEA:14096
is_a: GO:0070529 ! L-tryptophan aminotransferase activity

[Term]
id: GO:0050363
name: tryptophan dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tryptophan + NAD(P)+ = (indol-3-yl)pyruvate + NH3 + NAD(P)H + H+." [EC:1.4.1.19, MetaCyc:TRYPTOPHAN-DEHYDROGENASE-RXN]
synonym: "L-Trp-dehydrogenase activity" EXACT [EC:1.4.1.19]
synonym: "L-tryptophan dehydrogenase activity" EXACT [EC:1.4.1.19]
synonym: "L-tryptophan:NAD(P)+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.19]
synonym: "NAD(P)+-L-tryptophan dehydrogenase activity" EXACT [EC:1.4.1.19]
synonym: "TDH" RELATED [EC:1.4.1.19]
synonym: "TrpDH activity" EXACT [EC:1.4.1.19]
xref: EC:1.4.1.19
xref: MetaCyc:TRYPTOPHAN-DEHYDROGENASE-RXN
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050364
name: tryptophan dimethylallyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: dimethylallyl diphosphate + L-tryptophan = diphosphate + 4-(3-methylbut-2-enyl)-L-tryptophan." [EC:2.5.1.34, MetaCyc:TRYPTOPHAN-DIMETHYLALLYLTRANSFERASE-RXN]
synonym: "4-(gamma,gamma-dimethylallyl)tryptophan synthase activity" EXACT [EC:2.5.1.34]
synonym: "dimethylallyl-diphosphate:L-tryptophan dimethylallyltransferase activity" EXACT [EC:2.5.1.34]
synonym: "dimethylallylpyrophosphate:L-tryptophan dimethylallyltransferase activity" EXACT [EC:2.5.1.34]
synonym: "dimethylallylpyrophosphate:tryptophan dimethylallyl transferase activity" EXACT [EC:2.5.1.34]
synonym: "dimethylallyltryptophan synthetase activity" EXACT [EC:2.5.1.34]
synonym: "DMAT synthetase activity" EXACT [EC:2.5.1.34]
xref: EC:2.5.1.34
xref: MetaCyc:TRYPTOPHAN-DIMETHYLALLYLTRANSFERASE-RXN
xref: RHEA:14176
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0050365
name: tryptophanamidase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tryptophanamide + H(2)O = L-tryptophan + NH(4)(+)." [EC:3.5.1.57, RHEA:11015]
synonym: "L-tryptophan aminopeptidase" BROAD [EC:3.5.1.57]
synonym: "L-tryptophanamide amidohydrolase activity" EXACT [EC:3.5.1.57]
synonym: "tryptophan aminopeptidase" BROAD [EC:3.5.1.57]
xref: EC:3.5.1.57
xref: KEGG:R00682
xref: MetaCyc:TRYPTOPHANAMIDASE-RXN
xref: RHEA:11015
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050366
name: tyramine N-feruloyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: feruloyl-CoA + tyramine = CoA + N-feruloyltyramine." [EC:2.3.1.110, MetaCyc:TYRAMINE-N-FERULOYLTRANSFERASE-RXN]
synonym: "feruloyl-CoA tyramine N-feruloyl-CoA transferase activity" EXACT [EC:2.3.1.110]
synonym: "feruloyl-CoA:tyramine N-(hydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.110]
synonym: "feruloyltyramine synthase activity" EXACT [EC:2.3.1.110]
synonym: "tyramine feruloyltransferase activity" EXACT [EC:2.3.1.110]
synonym: "tyramine N-feruloyl-CoA transferase activity" EXACT [EC:2.3.1.110]
xref: EC:2.3.1.110
xref: MetaCyc:TYRAMINE-N-FERULOYLTRANSFERASE-RXN
xref: RHEA:19688
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0050367
name: tyrosine-arginine ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arginine + L-tyrosine + ATP = L-tyrosyl-L-arginine + AMP + diphosphate + 2 H(+)." [EC:6.3.2.24, RHEA:15348]
synonym: "kyotorphin synthase activity" EXACT [EC:6.3.2.24]
synonym: "kyotorphin synthetase activity" EXACT [EC:6.3.2.24]
synonym: "kyotorphin-synthesizing enzyme activity" EXACT [EC:6.3.2.24]
synonym: "L-tyrosine:L-arginine ligase (AMP-forming)" EXACT [EC:6.3.2.24]
synonym: "tyrosyl-arginine synthase activity" EXACT [EC:6.3.2.24]
xref: EC:6.3.2.24
xref: KEGG:R00735
xref: MetaCyc:TYROSINE--ARGININE-LIGASE-RXN
xref: RHEA:15348
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0050368
name: tyrosine 2,3-aminomutase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tyrosine = 3-amino-3-(4-hydroxyphenyl)propanoate." [EC:5.4.3.6, RHEA:15784]
synonym: "L-tyrosine 2,3-aminomutase activity" EXACT [EC:5.4.3.6]
synonym: "tyrosine alpha,beta-mutase activity" EXACT [EC:5.4.3.6]
xref: EC:5.4.3.6
xref: KEGG:R00739
xref: MetaCyc:TYROSINE-23-AMINOMUTASE-RXN
xref: RHEA:15784
is_a: GO:0016869 ! intramolecular transferase activity, transferring amino groups

[Term]
id: GO:0050369
name: [tyrosine 3-monooxygenase] kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + [tyrosine-3-monooxygenase] = ADP + phospho-[tyrosine-3-monooxygenase]." [EC:2.7.11.6, MetaCyc:TYROSINE-3-MONOOXYGENASE-KINASE-RXN]
synonym: "ATP:tyrosine-3-monoxygenase phosphotransferase activity" EXACT [EC:2.7.11.6]
synonym: "pheochromocytoma tyrosine hydroxylase-associated kinase activity" EXACT [EC:2.7.11.6]
synonym: "STK4" RELATED [EC:2.7.11.6]
synonym: "tyrosine 3-monooxygenase kinase (phosphorylating) activity" EXACT [EC:2.7.11.6]
synonym: "tyrosine 3-monooxygenase kinase activity" EXACT []
xref: EC:2.7.11.6
xref: MetaCyc:2.7.11.6-RXN
is_a: GO:0004672 ! protein kinase activity

[Term]
id: GO:0050370
name: tyrosine N-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: tyrosine + O2 + NADPH + H+ = N-hydroxytyrosine + NADP+ + H2O." [EC:1.14.13.41, MetaCyc:TYROSINE-N-MONOOXYGENASE-RXN]
synonym: "CYP79A1 activity" NARROW [EC:1.14.13.41]
synonym: "L-tyrosine,NADPH:oxygen oxidoreductase (N-hydroxylating)" EXACT [EC:1.14.13.41]
synonym: "tyrosine N-hydroxylase activity" EXACT []
xref: EC:1.14.13.41
xref: MetaCyc:TYROSINE-N-MONOOXYGENASE-RXN
xref: RHEA:25084
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050371
name: tyrosine phenol-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tyrosine + H(2)O = NH(4)(+) + phenol + pyruvate." [EC:4.1.99.2, RHEA:21707]
subset: gosubset_prok
synonym: "beta-tyrosinase activity" EXACT [EC:4.1.99.2]
synonym: "L-tyrosine phenol-lyase (deaminating)" EXACT [EC:4.1.99.2]
synonym: "L-tyrosine phenol-lyase (deaminating; pyruvate-forming)" EXACT [EC:4.1.99.2]
xref: EC:4.1.99.2
xref: KEGG:R00728
xref: MetaCyc:TYROSINE-PHENOL-LYASE-RXN
xref: RHEA:21707
is_a: GO:0016830 ! carbon-carbon lyase activity

[Term]
id: GO:0050372
name: ubiquitin-calmodulin ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: n ATP + calmodulin + n ubiquitin = n AMP + n diphosphate + ubiquitin(n)-calmodulin." [MetaCyc:UBIQUITIN--CALMODULIN-LIGASE-RXN]
synonym: "calmodulin:ubiquitin ligase (AMP-forming)" EXACT [EC:6.3.2.21]
synonym: "ubiquitin-calmodulin synthetase activity" EXACT [EC:6.3.2.21]
synonym: "ubiquityl-calmodulin synthase activity" EXACT [EC:6.3.2.21]
synonym: "ubiquityl-calmodulin synthetase activity" EXACT [EC:6.3.2.21]
synonym: "uCaM-synthetase activity" EXACT [EC:6.3.2.21]
xref: MetaCyc:UBIQUITIN--CALMODULIN-LIGASE-RXN
is_a: GO:0004842 ! ubiquitin-protein transferase activity

[Term]
id: GO:0050373
name: UDP-arabinose 4-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-L-arabinose = UDP-alpha-D-xylose." [EC:5.1.3.5, RHEA:11323]
synonym: "UDP arabinose epimerase activity" EXACT [EC:5.1.3.5]
synonym: "UDP-D-xylose 4-epimerase activity" EXACT [EC:5.1.3.5]
synonym: "UDP-D-xylose-4-epimerase activity" EXACT []
synonym: "UDP-L-arabinose 4-epimerase activity" EXACT [EC:5.1.3.5]
synonym: "UDParabinose 4-epimerase activity" EXACT [EC:5.1.3.5]
synonym: "uridine 5'-diphosphate-D-xylose 4-epimerase activity" EXACT [EC:5.1.3.5]
synonym: "uridine diphosphoarabinose epimerase activity" EXACT [EC:5.1.3.5]
xref: EC:5.1.3.5
xref: KEGG:R01473
xref: MetaCyc:UDP-ARABINOSE-4-EPIMERASE-RXN
xref: RHEA:11323
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0050374
name: UDP-galacturonate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(+) + UDP-alpha-D-galacturonate = CO(2) + UDP-L-arabinose." [EC:4.1.1.67, RHEA:19728]
synonym: "UDP-D-galacturonate carboxy-lyase (UDP-L-arabinose-forming)" EXACT [EC:4.1.1.67]
synonym: "UDP-D-galacturonate carboxy-lyase activity" EXACT [EC:4.1.1.67]
synonym: "UDP-galacturonic acid decarboxylase activity" EXACT [EC:4.1.1.67]
synonym: "UDPgalacturonate decarboxylase activity" EXACT [EC:4.1.1.67]
synonym: "UDPGalUA carboxy lyase activity" EXACT [EC:4.1.1.67]
xref: EC:4.1.1.67
xref: KEGG:R02636
xref: MetaCyc:UDP-GALACTURONATE-DECARBOXYLASE-RXN
xref: RHEA:19728
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050376
name: UDP-glucosamine 4-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucosamine = UDP-galactosamine." [EC:5.1.3.16, MetaCyc:UDP-GLUCOSAMINE-EPIMERASE-RXN]
synonym: "UDP-glucosamine epimerase activity" EXACT []
synonym: "UDPglucosamine 4-epimerase activity" EXACT [EC:5.1.3.16]
xref: EC:5.1.3.16
xref: MetaCyc:UDP-GLUCOSAMINE-EPIMERASE-RXN
xref: RHEA:23495
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0050377
name: UDP-glucose 4,6-dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-D-glucose = H(2)O + UDP-4-dehydro-6-deoxy-D-glucose." [EC:4.2.1.76, RHEA:21503]
synonym: "UDP-D-glucose oxidoreductase activity" EXACT [EC:4.2.1.76]
synonym: "UDP-D-glucose-4,6-hydrolyase activity" EXACT [EC:4.2.1.76]
synonym: "UDP-glucose 4,6-hydro-lyase (UDP-4-dehydro-6-deoxy-D-glucose-forming)" EXACT [EC:4.2.1.76]
synonym: "UDP-glucose 4,6-hydro-lyase activity" EXACT [EC:4.2.1.76]
synonym: "UDPglucose 4,6-dehydratase activity" EXACT [EC:4.2.1.76]
synonym: "UDPglucose 4,6-hydro-lyase activity" EXACT [EC:4.2.1.76]
xref: EC:4.2.1.76
xref: KEGG:R00293
xref: MetaCyc:UDP-GLUCOSE-46-DEHYDRATASE-RXN
xref: RHEA:21503
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050378
name: UDP-glucuronate 4-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-alpha-D-glucuronate = UDP-alpha-D-galacturonate." [EC:5.1.3.6, RHEA:11407]
synonym: "UDP glucuronic epimerase activity" EXACT [EC:5.1.3.6]
synonym: "UDP-D-galacturonic acid 4-epimerase activity" EXACT [EC:5.1.3.6]
synonym: "UDP-galacturonate 4-epimerase activity" EXACT [EC:5.1.3.6]
synonym: "UDPglucuronate 4-epimerase activity" EXACT [EC:5.1.3.6]
synonym: "uridine diphospho-D-galacturonic acid" RELATED [EC:5.1.3.6]
synonym: "uridine diphosphoglucuronate epimerase activity" EXACT [EC:5.1.3.6]
synonym: "uridine diphosphoglucuronic epimerase activity" EXACT [EC:5.1.3.6]
xref: EC:5.1.3.6
xref: KEGG:R01385
xref: MetaCyc:PWY-4861
xref: MetaCyc:UDP-GLUCURONATE-4-EPIMERASE-RXN
xref: RHEA:11407
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0050379
name: UDP-glucuronate 5'-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-alpha-D-glucuronate = UDP-L-iduronate." [EC:5.1.3.12, RHEA:14680]
subset: gosubset_prok
synonym: "C-5-uronosyl epimerase activity" EXACT [EC:5.1.3.12]
synonym: "UDP-glucuronate 5' epimerase activity" EXACT []
synonym: "UDP-glucuronic acid 5'-epimerase activity" EXACT [EC:5.1.3.12]
synonym: "UDP-glucuronic acid epimerase activity" EXACT [EC:5.1.3.12]
synonym: "UDPglucuronate 5'-epimerase activity" EXACT [EC:5.1.3.12]
synonym: "uridine diphosphoglucuronate 5'-epimerase activity" EXACT [EC:5.1.3.12]
xref: EC:5.1.3.12
xref: KEGG:R01387
xref: MetaCyc:UDP-GLUCURONATE-5-EPIMERASE-RXN
xref: RHEA:14680
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0050380
name: undecaprenyl-diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: all-trans-undecaprenyl diphosphate + H(2)O = all-trans-undecaprenyl phosphate + H(+) + phosphate." [EC:3.6.1.27, RHEA:17072]
subset: gosubset_prok
synonym: "C(55)-isoprenyl diphosphatase activity" EXACT [EC:3.6.1.27]
synonym: "C(55)-isoprenyl pyrophosphatase activity" EXACT [EC:3.6.1.27]
synonym: "C55-isoprenyl diphosphatase activity" EXACT [EC:3.6.1.27]
synonym: "C55-isoprenyl pyrophosphatase activity" EXACT [EC:3.6.1.27]
synonym: "isoprenyl pyrophosphatase activity" EXACT [EC:3.6.1.27]
synonym: "undecaprenyl-diphosphate phosphohydrolase activity" EXACT [EC:3.6.1.27]
xref: EC:3.6.1.27
xref: KEGG:R05627
xref: MetaCyc:UNDECAPRENYL-DIPHOSPHATASE-RXN
xref: RHEA:17072
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0050382
name: uracil-5-carboxylate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(+) + uracil 5-carboxylate = CO(2) + uracil." [EC:4.1.1.66, RHEA:17688]
synonym: "uracil-5-carboxylate carboxy-lyase (uracil-forming)" EXACT [EC:4.1.1.66]
synonym: "uracil-5-carboxylate carboxy-lyase activity" EXACT [EC:4.1.1.66]
synonym: "uracil-5-carboxylic acid decarboxylase activity" EXACT [EC:4.1.1.66]
xref: EC:4.1.1.66
xref: KEGG:R00973
xref: MetaCyc:URACIL-5-CARBOXYLATE-DECARBOXYLASE-RXN
xref: RHEA:17688
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050383
name: uracil dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: uracil + acceptor = barbiturate + reduced acceptor." [EC:1.17.99.4, MetaCyc:URACIL-DEHYDROGENASE-RXN]
xref: EC:1.17.99.4
xref: MetaCyc:URACIL-DEHYDROGENASE-RXN
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0050384
name: urate-ribonucleotide phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-(beta-D-ribofuranosyl)uric acid + phosphate = alpha-D-ribose 1-phosphate + H(+) + urate." [EC:2.4.2.16, RHEA:13912]
synonym: "UAR phosphorylase activity" EXACT [EC:2.4.2.16]
synonym: "urate-ribonucleotide:phosphate alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.16]
synonym: "urate-ribonucleotide:phosphate D-ribosyltransferase activity" EXACT [EC:2.4.2.16]
xref: EC:2.4.2.16
xref: KEGG:R02646
xref: MetaCyc:URATE-RIBONUCLEOTIDE-PHOSPHORYLASE-RXN
xref: RHEA:13912
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0050385
name: ureidoglycolate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-ureidoglycolate = glyoxylate + urea." [EC:4.3.2.3, RHEA:11307]
comment: Take care to annotate to the reaction, not simply by enzyme name. Note that the name "ureidoglycolate hydrolase" (listed as a synonym here) has variously been used to refer to two distinctly different enzymes. Both enzymes act on ureidoglycolate and produce glyoxylate, but the mechanism and reaction products are different. The "ureidoglycolate hydrolase" listed in the Enzyme commission (EC) is a ureidoglycolate amidohydrolase, releasing ammonia, (EC 3.5.3.19, GO:0004848). The "ureidoglycolate hydrolase" characterized in PMID:3915539 (published prior to the EC designation of EC 3.5.3.19) is a ureidoglycolate lyase, releasing urea (EC 4.3.2.3, GO:0050385). The inappropriate labelling of ureidoglycolate lyase as EC 3.5.3.19 has caused much confusion in the literature (see PMID:24107613). Take care to correctly annotate based on the reaction products, rather than name.
synonym: "(S)-ureidoglycolate urea-lyase (glyoxylate-forming)" EXACT [EC:4.3.2.3]
synonym: "(S)-ureidoglycolate urea-lyase activity" EXACT [EC:4.3.2.3]
synonym: "ureidoglycolase activity" RELATED [EC:4.3.2.3]
synonym: "ureidoglycolatase activity" RELATED [EC:4.3.2.3]
synonym: "ureidoglycolate hydrolase activity" RELATED [PMID:24107613]
xref: EC:4.3.2.3
xref: KEGG:R00776
xref: MetaCyc:UREIDOGLYCOLATE-LYASE-RXN
xref: RHEA:11307
is_a: GO:0016842 ! amidine-lyase activity

[Term]
id: GO:0050386
name: ureidosuccinase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-carbamoyl-L-aspartate + H(2)O + 2 H(+) = L-aspartate + CO(2) + NH(4)(+)." [EC:3.5.1.7, RHEA:14368]
synonym: "N-carbamoyl-L-aspartate amidohydrolase activity" EXACT [EC:3.5.1.7]
xref: EC:3.5.1.7
xref: KEGG:R00484
xref: MetaCyc:UREIDOSUCCINASE-RXN
xref: RHEA:14368
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050387
name: urethanase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + H(+) + urethane = CO(2) + ethanol + NH(4)(+)." [EC:3.5.1.75, RHEA:21375]
synonym: "urethane amidohydrolase (decarboxylating)" EXACT [EC:3.5.1.75]
synonym: "urethane hydrolase activity" EXACT [EC:3.5.1.75]
xref: EC:3.5.1.75
xref: KEGG:R02359
xref: MetaCyc:URETHANASE-RXN
xref: RHEA:21375
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050388
name: uronate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-galacturonate + H(2)O + NAD(+) = galactarate + 2 H(+) + NADH." [EC:1.1.1.203, RHEA:22407]
synonym: "uronate: NAD-oxidoreductase activity" EXACT [EC:1.1.1.203]
synonym: "uronate:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.203]
synonym: "uronic acid dehydrogenase activity" EXACT [EC:1.1.1.203]
xref: EC:1.1.1.203
xref: KEGG:R01981
xref: MetaCyc:URONATE-DEHYDROGENASE-RXN
xref: RHEA:22407
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050389
name: uronolactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucurono-6,2-lactone + H2O = D-glucuronate." [EC:3.1.1.19, MetaCyc:URONOLACTONASE-RXN]
synonym: "D-glucurono-6,2-lactone lactonohydrolase activity" EXACT [EC:3.1.1.19]
synonym: "glucuronolactonase activity" EXACT [EC:3.1.1.19]
xref: EC:3.1.1.19
xref: MetaCyc:URONOLACTONASE-RXN
xref: RHEA:13340
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0050390
name: valine decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-valine + H(+) = 2-methylpropanamine + CO(2)." [EC:4.1.1.14, RHEA:18992]
synonym: "L-valine carboxy-lyase (2-methylpropanamine-forming)" EXACT [EC:4.1.1.14]
synonym: "L-valine carboxy-lyase activity" EXACT [EC:4.1.1.14]
synonym: "leucine decarboxylase activity" EXACT [EC:4.1.1.14]
xref: EC:4.1.1.14
xref: KEGG:R01437
xref: MetaCyc:VALINE-DECARBOXYLASE-RXN
xref: RHEA:18992
xref: UM-BBD_reactionID:r1052
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050391
name: valine dehydrogenase (NADP) activity
namespace: molecular_function
def: "Catalysis of the reaction: L-valine + H2O + NADP+ = 3-methyl-2-oxobutanoate + NH3 + NADPH." [EC:1.4.1.8, MetaCyc:VALINE-DEHYDROGENASE-NADP+-RXN]
synonym: "L-valine:NADP+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.8]
synonym: "valine dehydrogenase (NADP+) activity" EXACT []
synonym: "valine dehydrogenase (nicotinanide adenine dinucleotide phosphate)" EXACT [EC:1.4.1.8]
xref: EC:1.4.1.8
xref: MetaCyc:VALINE-DEHYDROGENASE-NADP+-RXN
xref: RHEA:11159
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050392
name: vicianin beta-glucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-vicianin + H(2)O = mandelonitrile + vicianose." [EC:3.2.1.119, RHEA:14044]
synonym: "(R)-vicianin beta-D-glucohydrolase activity" EXACT [EC:3.2.1.119]
synonym: "vicianin b-glucosidase activity" EXACT []
synonym: "vicianin hydrolase activity" EXACT [EC:3.2.1.119]
xref: EC:3.2.1.119
xref: KEGG:R03642
xref: MetaCyc:VICIANIN-BETA-GLUCOSIDASE-RXN
xref: RHEA:14044
is_a: GO:0008422 ! beta-glucosidase activity

[Term]
id: GO:0050393
name: vinylacetyl-CoA delta-isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: vinylacetyl-CoA = crotonoyl-CoA." [EC:5.3.3.3, RHEA:10575]
subset: gosubset_prok
synonym: "delta3-cis-delta2-trans-enoyl-CoA isomerase" BROAD [EC:5.3.3.3]
synonym: "vinylacetyl coenzyme A delta-isomerase activity" EXACT [EC:5.3.3.3]
synonym: "vinylacetyl coenzyme A isomerase activity" EXACT [EC:5.3.3.3]
synonym: "vinylacetyl-CoA D-isomerase activity" EXACT []
synonym: "vinylacetyl-CoA delta3-delta2-isomerase activity" EXACT [EC:5.3.3.3]
xref: EC:5.3.3.3
xref: KEGG:R03031
xref: MetaCyc:VINYLACETYL-COA-DELTA-ISOMERASE-RXN
xref: RHEA:10575
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0050394
name: viomycin kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + viomycin = ADP + O-phosphoviomycin." [EC:2.7.1.103, MetaCyc:VIOMYCIN-KINASE-RXN]
subset: gosubset_prok
synonym: "ATP:viomycin O-phosphotransferase activity" EXACT [EC:2.7.1.103]
synonym: "capreomycin phosphotransferase activity" EXACT [EC:2.7.1.103]
synonym: "viomycin phosphotransferase activity" EXACT [EC:2.7.1.103]
xref: EC:2.7.1.103
xref: MetaCyc:VIOMYCIN-KINASE-RXN
xref: RHEA:20512
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0050395
name: vitexin beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-D-glucose + vitexin = H(+) + UDP + vitexin 2''-O-beta-D-glucoside." [EC:2.4.1.105, RHEA:21959]
synonym: "UDP-glucose:vitexin 2''-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.105]
synonym: "UDPglucose:vitexin 2''-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.105]
synonym: "uridine diphosphoglucose-vitexin 2''-glucosyltransferase activity" EXACT [EC:2.4.1.105]
synonym: "vitexin b-glucosyltransferase activity" EXACT []
xref: EC:2.4.1.105
xref: KEGG:R03565
xref: MetaCyc:VITEXIN-BETA-GLUCOSYLTRANSFERASE-RXN
xref: RHEA:21959
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0050396
name: vomifoliol 4'-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (6S,9R)-6-hydroxy-3-oxo-alpha-ionol + NAD(+) = (6S)-6-hydroxy-3-oxo-alpha-ionone + H(+) + NADH." [EC:1.1.1.221, RHEA:22807]
synonym: "vomifoliol:NAD+ 4'-oxidoreductase activity" EXACT [EC:1.1.1.221]
xref: EC:1.1.1.221
xref: KEGG:R04412
xref: MetaCyc:VOMIFOLIOL-4-DEHYDROGENASE-RXN
xref: RHEA:22807
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050397
name: Watasenia-luciferin 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: Watasenia luciferin + O2 = oxidized Watasenia luciferin + CO2 + light." [EC:1.13.12.8, MetaCyc:WATASEMIA-LUCIFERIN-2-MONOOXYGENASE-RXN]
synonym: "luciferase activity" BROAD [EC:1.13.12.8]
synonym: "Watasenia-luciferin:oxygen 2-oxidoreductase (decarboxylating)" EXACT [EC:1.13.12.8]
synonym: "Watasenia-type luciferase activity" EXACT [EC:1.13.12.8]
xref: EC:1.13.12.8
xref: MetaCyc:WATASEMIA-LUCIFERIN-2-MONOOXYGENASE-RXN
xref: RHEA:18060
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)
is_a: GO:0045289 ! luciferin monooxygenase activity

[Term]
id: GO:0050398
name: wax-ester hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: a wax ester + H2O = a long-chain alcohol + a long-chain carboxylate." [EC:3.1.1.50, MetaCyc:WAX-ESTER-HYDROLASE-RXN]
synonym: "jojoba wax esterase" NARROW [EC:3.1.1.50]
synonym: "wax-ester acylhydrolase activity" EXACT [EC:3.1.1.50]
synonym: "WEH" RELATED [EC:3.1.1.50]
xref: EC:3.1.1.50
xref: MetaCyc:WAX-ESTER-HYDROLASE-RXN
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0050399
name: xanthommatin reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,12-dihydroxanthommatin + NAD(+) = H(+) + NADH + xanthommatin." [EC:1.3.1.41, RHEA:13420]
synonym: "5,12-dihydroxanthommatin:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.41]
xref: EC:1.3.1.41
xref: KEGG:R03787
xref: MetaCyc:XANTHOMMATIN-REDUCTASE-RXN
xref: RHEA:13420
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050400
name: xylitol kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + xylitol = ADP + 2 H(+) + xylitol 5-phosphate." [EC:2.7.1.122, RHEA:20212]
synonym: "ATP:xylitol 5-phosphotransferase activity" EXACT [EC:2.7.1.122]
synonym: "xylitol phosphotransferase activity" EXACT [EC:2.7.1.122]
xref: EC:2.7.1.122
xref: KEGG:R02136
xref: MetaCyc:XYLITOL-KINASE-RXN
xref: RHEA:20212
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0050401
name: xylonate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-xylonate = 2-dehydro-3-deoxy-D-arabinonate + H(2)O." [EC:4.2.1.82, RHEA:19160]
synonym: "D-xylo-aldonate dehydratase activity" EXACT [EC:4.2.1.82]
synonym: "D-xylonate dehydratase activity" EXACT [EC:4.2.1.82]
synonym: "D-xylonate hydro-lyase (2-dehydro-3-deoxy-D-xylonate-forming)" EXACT [EC:4.2.1.82]
synonym: "D-xylonate hydro-lyase activity" EXACT [EC:4.2.1.82]
xref: EC:4.2.1.82
xref: KEGG:R02429
xref: MetaCyc:XYLONATE-DEHYDRATASE-RXN
xref: RHEA:19160
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050402
name: xylono-1,4-lactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-xylono-1,4-lactone + H2O = D-xylonate." [EC:3.1.1.68, MetaCyc:XYLONO-14-LACTONASE-RXN]
synonym: "D-xylono-1,4-lactone lactonohydrolase activity" EXACT [EC:3.1.1.68]
synonym: "xylono-g-lactonase activity" EXACT [EC:3.1.1.68]
synonym: "xylonolactonase activity" EXACT [EC:3.1.1.68]
xref: EC:3.1.1.68
xref: MetaCyc:XYLONO-14-LACTONASE-RXN
xref: RHEA:18344
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0050403
name: trans-zeatin O-beta-D-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-zeatin + UDP-D-glucose = O-beta-D-glucosyl-trans-zeatin + H(+) + UDP." [EC:2.4.1.203, RHEA:23227]
synonym: "UDP-glucose:trans-zeatin O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.203]
synonym: "UDPglucose:trans-zeatin O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.203]
synonym: "uridine diphosphoglucose-zeatin O-glucosyltransferase activity" EXACT [EC:2.4.1.203]
synonym: "zeatin O-b-D-glucosyltransferase activity" EXACT []
synonym: "zeatin O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.203]
synonym: "zeatin O-glucosyltransferase activity" EXACT [EC:2.4.1.203]
xref: EC:2.4.1.203
xref: KEGG:R02118
xref: MetaCyc:RXN-4723
xref: RHEA:23227
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0050404
name: zeatin O-beta-D-xylosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-alpha-D-xylose + zeatin = O-beta-D-xylosylzeatin + H(+) + UDP." [EC:2.4.2.40, RHEA:14724]
comment: Note that this function was formerly EC:2.4.1.204.
synonym: "UDP-D-xylose:zeatin O-beta-D-xylosyltransferase activity" EXACT [EC:2.4.2.40]
synonym: "uridine diphosphoxylose-zeatin xylosyltransferase activity" EXACT [EC:2.4.2.40]
synonym: "zeatin O-b-D-xylosyltransferase activity" EXACT []
synonym: "zeatin O-xylosyltransferase activity" EXACT [EC:2.4.2.40]
xref: EC:2.4.2.40
xref: KEGG:R02119
xref: MetaCyc:ZEATIN-O-BETA-D-XYLOSYLTRANSFERASE-RXN
xref: RHEA:14724
is_a: GO:0035252 ! UDP-xylosyltransferase activity

[Term]
id: GO:0050405
name: [acetyl-CoA carboxylase] kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + [acetyl-CoA carboxylase] = ADP + [acetyl-CoA carboxylase] phosphate." [EC:2.7.11.27, MetaCyc:[ACETYL-COA-CARBOXYLASE\]-KINASE-RXN]
synonym: "acetyl coenzyme A carboxylase kinase (phosphorylating) activity" EXACT [EC:2.7.11.27]
synonym: "acetyl-CoA carboxylase bound kinase activity" NARROW [EC:2.7.11.27]
synonym: "acetyl-CoA carboxylase kinase (AMP-activated) activity" EXACT [EC:2.7.11.27]
synonym: "acetyl-CoA carboxylase kinase (cAMP-independent) activity" EXACT [EC:2.7.11.27]
synonym: "acetyl-CoA carboxylase kinase 2 activity" NARROW [EC:2.7.11.27]
synonym: "acetyl-CoA carboxylase kinase activity" EXACT [EC:2.7.11.27]
synonym: "acetyl-CoA carboxylase kinase-2 activity" NARROW [EC:2.7.11.27]
synonym: "acetyl-CoA carboxylase kinase-3 (AMP-activated) activity" NARROW [EC:2.7.11.27]
synonym: "acetyl-coenzyme A carboxylase kinase activity" EXACT [EC:2.7.11.27]
synonym: "ACK2" RELATED [EC:2.7.11.27]
synonym: "ACK3" RELATED [EC:2.7.11.27]
synonym: "AMPK" RELATED [EC:2.7.11.27]
synonym: "ATP:acetyl-CoA carboxylase phosphotransferase activity" EXACT [EC:2.7.11.27]
synonym: "I-peptide kinase activity" NARROW [EC:2.7.11.27]
synonym: "STK5" RELATED [EC:2.7.11.27]
xref: EC:2.7.11.27
xref: MetaCyc:2.7.11.27-RXN
is_a: GO:0004672 ! protein kinase activity

[Term]
id: GO:0050406
name: [acetyl-CoA carboxylase]-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: [acetyl-CoA carboxylase]-phosphate + H2O = [acetyl-CoA carboxylase] + phosphate." [EC:3.1.3.44, MetaCyc:ACETYL-COA-CARBOXYLASE-PHOSPHATASE-RXN]
synonym: "acetyl-CoA carboxylase-phosphatase activity" EXACT [EC:3.1.3.44]
synonym: "acetyl-CoA:carbon-dioxide ligase (ADP-forming)-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.44]
xref: EC:3.1.3.44
xref: MetaCyc:ACETYL-COA-CARBOXYLASE-PHOSPHATASE-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0050407
name: [glycogen-synthase-D] phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: [glycogen-synthase D] + H2O = [glycogen-synthase I] + phosphate." [EC:3.1.3.42, MetaCyc:GLYCOGEN-SYNTHASE-D-PHOSPHATASE-RXN]
synonym: "glycogen glucosyltransferase phosphatase activity" EXACT [EC:3.1.3.42]
synonym: "glycogen synthase D phosphatase activity" EXACT [EC:3.1.3.42]
synonym: "glycogen synthase phosphatase activity" EXACT [EC:3.1.3.42]
synonym: "glycogen synthetase phosphatase activity" EXACT [EC:3.1.3.42]
synonym: "glycogen-synthase-D phosphatase activity" EXACT [EC:3.1.3.42]
synonym: "Mg2+ dependent glycogen synthase phosphatase activity" EXACT [EC:3.1.3.42]
synonym: "phosphatase type 2oC" RELATED [EC:3.1.3.42]
synonym: "UDP-glucose:glycogen 4-alpha-D-glucosyltransferase-D phosphohydrolase activity" EXACT [EC:3.1.3.42]
synonym: "UDP-glycogen glucosyltransferase phosphatase activity" EXACT [EC:3.1.3.42]
synonym: "UDPglucose-glycogen glucosyltransferase phosphatase activity" EXACT [EC:3.1.3.42]
synonym: "UDPglucose:glycogen 4-alpha-D-glucosyltransferase-D phosphohydrolase activity" EXACT [EC:3.1.3.42]
synonym: "uridine diphosphoglucose-glycogen glucosyltransferase phosphatase activity" EXACT [EC:3.1.3.42]
xref: EC:3.1.3.42
xref: MetaCyc:GLYCOGEN-SYNTHASE-D-PHOSPHATASE-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0050408
name: [pyruvate kinase]-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: [pyruvate kinase] phosphate + H2O = [pyruvate kinase] + phosphate." [EC:3.1.3.49, MetaCyc:PYRUVATE-KINASE-PHOSPHATASE-RXN]
synonym: "ATP:pyruvate 2-O-phosphotransferase-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.49]
synonym: "pyruvate kinase phosphatase activity" EXACT [EC:3.1.3.49]
synonym: "pyruvate kinase-phosphatase activity" EXACT [EC:3.1.3.49]
xref: EC:3.1.3.49
xref: MetaCyc:PYRUVATE-KINASE-PHOSPHATASE-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0050409
name: indolylacetylinositol arabinosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1L-1-O-(indol-3-yl)acetyl-myo-inositol + UDP-L-arabinose = (indol-3-yl)acetyl-myo-inositol 3-L-arabinoside + H(+) + UDP." [EC:2.4.2.34, RHEA:19508]
subset: gosubset_prok
synonym: "arabinosylindolylacetylinositol synthase activity" EXACT [EC:2.4.2.34]
synonym: "UDP-L-arabinose:(indol-3-yl)acetyl-myo-inositol L-arabinosyltransferase activity" EXACT [EC:2.4.2.34]
synonym: "UDP-L-arabinose:indol-3-ylacetyl-myo-inositol L-arabinosyltransferase activity" EXACT [EC:2.4.2.34]
xref: EC:2.4.2.34
xref: KEGG:R04335
xref: MetaCyc:2.4.2.34-RXN
xref: RHEA:19508
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0052636 ! arabinosyltransferase activity

[Term]
id: GO:0050410
name: 3-oxolaurate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-oxolaurate + H(+) = 2-undecanone + CO(2)." [EC:4.1.1.56, RHEA:13388]
synonym: "3-oxododecanoate carboxy-lyase (2-undecanone-forming)" EXACT [EC:4.1.1.56]
synonym: "3-oxododecanoate carboxy-lyase activity" EXACT [EC:4.1.1.56]
synonym: "beta-ketoacyl decarboxylase activity" EXACT [EC:4.1.1.56]
synonym: "beta-ketolaurate decarboxylase activity" EXACT [EC:4.1.1.56]
xref: EC:4.1.1.56
xref: KEGG:R03747
xref: MetaCyc:3-OXOLAURATE-DECARBOXYLASE-RXN
xref: RHEA:13388
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050411
name: agaritine gamma-glutamyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: agaritine + acceptor-NH2 = 4-hydroxymethylphenylhydrazine + gamma-L-glutamyl-acceptor." [EC:2.3.2.9, MetaCyc:AGARITINE-GAMMA-GLUTAMYLTRANSFERASE-RXN]
synonym: "(gamma-L-glutamyl)-1-N-(4-hydroxymethylphenyl)hydrazine:(acceptor) gamma-glutamyltransferase activity" EXACT [EC:2.3.2.9]
synonym: "(gamma-L-glutamyl)-N1-(4-hydroxymethylphenyl)hydrazine:(acceptor) gamma-glutamyltransferase activity" EXACT [EC:2.3.2.9]
synonym: "agaritine g-glutamyltransferase activity" EXACT []
xref: EC:2.3.2.9
xref: MetaCyc:AGARITINE-GAMMA-GLUTAMYLTRANSFERASE-RXN
is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups

[Term]
id: GO:0050412
name: cinnamate beta-D-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-cinnamate + UDP-D-glucose = 1-O-trans-cinnamoyl-beta-D-glucopyranose + UDP." [EC:2.4.1.177, RHEA:13440]
synonym: "cinnamate b-D-glucosyltransferase activity" EXACT []
synonym: "cinnamate glucosyltransferase activity" EXACT []
synonym: "UDP-glucose:trans-cinnamate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.177]
synonym: "UDPG:t-cinnamate glucosyltransferase activity" EXACT [EC:2.4.1.177]
synonym: "UDPglucose:trans-cinnamate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.177]
synonym: "uridine diphosphoglucose-cinnamate glucosyltransferase activity" EXACT [EC:2.4.1.177]
xref: EC:2.4.1.177
xref: KEGG:R02256
xref: MetaCyc:CINNAMATE-GLUCOSYLTRANSFERASE-RXN
xref: RHEA:13440
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0050413
name: D-alanine 2-hydroxymethyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + D-alanine + H(2)O = (6S)-5,6,7,8-tetrahydrofolate + 2-methylserine." [EC:2.1.2.7, RHEA:10067]
synonym: "2-methylserine hydroxymethyltransferase activity" EXACT [EC:2.1.2.7]
synonym: "5,10-methylenetetrahydrofolate:D-alanine 2-hydroxymethyltransferase activity" EXACT [EC:2.1.2.7]
synonym: "D-alanine hydroxymethyltransferase activity" EXACT []
xref: EC:2.1.2.7
xref: KEGG:R01225
xref: MetaCyc:D-ALANINE-HYDROXYMETHYLTRANSFERASE-RXN
xref: RHEA:10067
is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity

[Term]
id: GO:0050414
name: formimidoylaspartate deiminase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-formimidoyl-L-aspartate + H2O = N-formyl-L-aspartate + NH3." [EC:3.5.3.5, MetaCyc:FORMIMINOASPARTATE-DEIMINASE-RXN]
synonym: "formiminoaspartate deiminase activity" EXACT []
synonym: "N-formimidoyl-L-aspartate iminohydrolase activity" EXACT [EC:3.5.3.5]
xref: EC:3.5.3.5
xref: MetaCyc:FORMIMINOASPARTATE-DEIMINASE-RXN
xref: RHEA:13664
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0050415
name: formimidoylglutamase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-formimidoyl-L-glutamate + H(2)O = L-glutamate + formamide." [EC:3.5.3.8, RHEA:22495]
subset: gosubset_prok
synonym: "formiminoglutamase activity" EXACT []
synonym: "formiminoglutamate hydrolase activity" EXACT [EC:3.5.3.8]
synonym: "N-formimidoyl-L-glutamate formimidoylhydrolase activity" EXACT [EC:3.5.3.8]
synonym: "N-formimino-L-glutamate formiminohydrolase activity" EXACT [EC:3.5.3.8]
synonym: "N-formiminoglutamate hydrolase activity" EXACT [EC:3.5.3.8]
xref: EC:3.5.3.8
xref: KEGG:R02285
xref: MetaCyc:FORMIMINOGLUTAMASE-RXN
xref: RHEA:22495
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0050416
name: formimidoylglutamate deiminase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-formimidoyl-L-glutamate + H2O = N-formyl-L-glutamate + NH3." [EC:3.5.3.13, MetaCyc:FORMIMINOGLUTAMATE-DEIMINASE-RXN]
subset: gosubset_prok
synonym: "formiminoglutamate deiminase activity" EXACT []
synonym: "formiminoglutamic iminohydrolase activity" EXACT [EC:3.5.3.13]
synonym: "N-formimidoyl-L-glutamate iminohydrolase activity" EXACT [EC:3.5.3.13]
xref: EC:3.5.3.13
xref: MetaCyc:FORMIMINOGLUTAMATE-DEIMINASE-RXN
xref: RHEA:22835
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0050417
name: glutamin-(asparagin-)ase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + L-glutamine = NH3 + L-glutamate; and H2O + L-asparagine = NH3 + L-aspartate." [EC:3.5.1.38, MetaCyc:GLUTAMINASE-ASPARAGIN-ASE-RXN]
subset: gosubset_prok
subset: mf_needs_review
synonym: "glutaminase-(asparagin-)ase activity" EXACT []
synonym: "glutaminase-asparaginase activity" EXACT [EC:3.5.1.38]
synonym: "L-ASNase/L-GLNase activity" EXACT [EC:3.5.1.38]
synonym: "L-asparagine/L-glutamine amidohydrolase activity" EXACT [EC:3.5.1.38]
synonym: "L-glutamine(L-asparagine) amidohydrolase activity" EXACT [EC:3.5.1.38]
xref: EC:3.5.1.38
xref: MetaCyc:GLUTAMINASE-ASPARAGIN-ASE-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050418
name: hydroxylamine reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NH3 + H2O + acceptor = hydroxylamine + reduced acceptor." [EC:1.7.99.1, MetaCyc:HYDROXYLAMINE-REDUCTASE-RXN]
subset: gosubset_prok
synonym: "ammonia:(acceptor) oxidoreductase activity" EXACT [EC:1.7.99.1]
synonym: "ammonia:acceptor oxidoreductase activity" EXACT [EC:1.7.99.1]
synonym: "hydroxylamine (acceptor) reductase activity" EXACT [EC:1.7.99.1]
xref: EC:1.7.99.1
xref: MetaCyc:HYDROXYLAMINE-REDUCTASE-RXN
xref: RHEA:22055
is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors

[Term]
id: GO:0050419
name: hydroxymandelonitrile lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxymandelonitrile = 4-hydroxybenzaldehyde + hydrocyanate." [EC:4.1.2.11, MetaCyc:HYDROXYMANDELONITRILE-LYASE-RXN]
synonym: "(S)-4-hydroxymandelonitrile 4-hydroxybenzaldehyde-lyase (cyanide-forming)" EXACT [EC:4.1.2.11]
synonym: "(S)-4-hydroxymandelonitrile hydroxybenzaldehyde-lyase activity" EXACT [EC:4.1.2.11]
synonym: "hydroxynitrile lyase activity" BROAD [EC:4.1.2.11]
synonym: "sorghum hydroxynitrile lyase activity" EXACT [EC:4.1.2.11]
xref: EC:4.1.2.11
xref: MetaCyc:HYDROXYMANDELONITRILE-LYASE-RXN
xref: RHEA:15980
is_a: GO:0047606 ! hydroxynitrilase activity

[Term]
id: GO:0050420
name: maltose synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 alpha-D-glucose 1-phosphate = maltose + 2 phosphate." [EC:2.4.1.139, MetaCyc:MALTOSE-SYNTHASE-RXN]
synonym: "alpha-D-glucose-1-phosphate:alpha-D-glucose-1-phosphate 4-alpha-D-glucosyltransferase (dephosphorylating)" EXACT [EC:2.4.1.139]
xref: EC:2.4.1.139
xref: MetaCyc:MALTOSE-SYNTHASE-RXN
xref: RHEA:22323
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0050421
name: nitrite reductase (NO-forming) activity
namespace: molecular_function
alt_id: GO:0016666
def: "Catalysis of the reaction: nitric oxide + H2O + ferricytochrome c = nitrite + ferrocytochrome c + 2 H+." [EC:1.7.2.1, MetaCyc:NITRITE-REDUCTASE-CYTOCHROME-RXN]
comment: Note that EC:1.7.99.3 was merged into this term.
subset: gosubset_prok
synonym: "[nitrite reductase (cytochrome)]" RELATED [EC:1.7.2.1]
synonym: "cd-cytochrome nitrite reductase activity" NARROW [EC:1.7.2.1]
synonym: "cytochrome c-551:O(2), NO(2)(+) oxidoreductase activity" NARROW [EC:1.7.2.1]
synonym: "cytochrome c-551:O2, NO2+ oxidoreductase activity" EXACT [EC:1.7.2.1]
synonym: "cytochrome cd activity" NARROW [EC:1.7.2.1]
synonym: "cytochrome cd1 activity" NARROW [EC:1.7.2.1]
synonym: "methyl viologen-nitrite reductase activity" NARROW [EC:1.7.2.1]
synonym: "nitric-oxide:ferricytochrome-c oxidoreductase activity" EXACT [EC:1.7.2.1]
synonym: "nitrite reductase (cytochrome) activity" EXACT []
synonym: "nitrite reductase (cytochrome; NO-forming) activity" EXACT [EC:1.7.2.1]
synonym: "nitrite reductase activity" EXACT []
synonym: "Pseudomonas cytochrome oxidase activity" NARROW [EC:1.7.2.1]
xref: EC:1.7.2.1
xref: MetaCyc:NITRITE-REDUCTASE-CYTOCHROME-RXN
is_a: GO:0016662 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor
is_a: GO:0098809 ! nitrite reductase activity

[Term]
id: GO:0050422
name: strictosidine beta-glucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3alpha(S)-strictosidine + H(2)O = D-glucose + strictosidine aglycone." [EC:3.2.1.105, RHEA:12920]
synonym: "strictosidine b-glucosidase activity" EXACT []
synonym: "strictosidine beta-D-glucohydrolase activity" EXACT [EC:3.2.1.105]
xref: EC:3.2.1.105
xref: KEGG:R03820
xref: MetaCyc:STRICTOSIDINE-BETA-GLUCOSIDASE-RXN
xref: RHEA:12920
is_a: GO:0008422 ! beta-glucosidase activity

[Term]
id: GO:0050423
name: thiamine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: thiamine + 2 O2 = thiamine acetic acid + 2 H2O2." [EC:1.1.3.23, MetaCyc:THIAMIN-OXIDASE-RXN]
synonym: "thiamin dehydrogenase activity" EXACT [EC:1.1.3.23]
synonym: "thiamin oxidase activity" EXACT [GOC:curators]
synonym: "thiamin:oxygen 5-oxidoreductase activity" EXACT [EC:1.1.3.23]
synonym: "thiamine dehydrogenase activity" EXACT [EC:1.1.3.23]
synonym: "thiamine:oxygen 5-oxidoreductase activity" EXACT [EC:1.1.3.23]
xref: EC:1.1.3.23
xref: MetaCyc:THIAMIN-OXIDASE-RXN
xref: RHEA:21283
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0050424
name: obsolete alanine carboxypeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H2O + peptidyl-L-alanine = L-alanine + peptide. The release of a C-terminal alanine from a peptide or a variety of pteroyl or acyl groups." [EC:3.4.17.6, MetaCyc:ALANINE-CARBOXYPEPTIDASE-RXN]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "alanine carboxypeptidase activity" EXACT []
synonym: "N-benzoyl-L-alanine-amidohydrolase activity" EXACT [EC:3.4.17.6]
xref: EC:3.4.17.6
xref: MetaCyc:ALANINE-CARBOXYPEPTIDASE-RXN
is_obsolete: true
replaced_by: GO:0004181

[Term]
id: GO:0050425
name: obsolete carboxypeptidase B activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H2O + peptidyl-L-lysine (or L-arginine) = L-lysine (or L-arginine) + peptide. Preferential release of a C-terminal lysine or arginine amino acid." [EC:3.4.17.2, MetaCyc:CARBOXYPEPTIDASE-B-RXN]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "carboxypeptidase B activity" EXACT []
synonym: "pancreatic carboxypeptidase B" RELATED [EC:3.4.17.2]
synonym: "peptidyl-L-lysine [L-arginine]hydrolase activity" EXACT [EC:3.4.17.2]
synonym: "protaminase activity" RELATED [EC:3.4.17.2]
synonym: "tissue carboxypeptidase B" RELATED [EC:3.4.17.2]
xref: EC:3.4.17.2
xref: MetaCyc:CARBOXYPEPTIDASE-B-RXN
is_obsolete: true
replaced_by: GO:0004181

[Term]
id: GO:0050426
name: obsolete peptidyl-glycinamidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H2O + peptidyl-glycinamide = glycinamide + peptide. Cleavage of C-terminal glycinamide from a polypeptide." [EC:3.4.19.2, MetaCyc:PEPTIDYL-GLYCINAMIDASE-RXN]
comment: This term was made obsolete because it represents a gene product.
synonym: "carboxamidopeptidase activity" EXACT [EC:3.4.19.2]
synonym: "carboxyamidase activity" EXACT [EC:3.4.19.2]
synonym: "peptidyl amino acid amide hydrolase activity" EXACT [EC:3.4.19.2]
synonym: "peptidyl carboxy-amidase activity" EXACT [EC:3.4.19.2]
synonym: "peptidyl carboxyamidase activity" EXACT [EC:3.4.19.2]
synonym: "peptidyl-glycinamidase activity" EXACT []
xref: EC:3.4.19.2
xref: MetaCyc:PEPTIDYL-GLYCINAMIDASE-RXN
is_obsolete: true
replaced_by: GO:0008242

[Term]
id: GO:0050427
name: 3'-phosphoadenosine 5'-phosphosulfate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems." [ISBN:0198506732]
subset: gosubset_prok
synonym: "3'-phosphoadenosine 5'-phosphosulfate metabolism" EXACT []
synonym: "3'-phosphoadenosine 5'-phosphosulphate metabolic process" EXACT []
synonym: "3'-phosphoadenosine 5'-phosphosulphate metabolism" EXACT []
synonym: "3'-phosphoadenylyl-sulfate metabolic process" EXACT []
synonym: "3'-phosphoadenylyl-sulfate metabolism" EXACT []
synonym: "adenosine 3'-phosphate 5'-phosphosulfate metabolic process" EXACT []
synonym: "adenosine 3'-phosphate 5'-phosphosulfate metabolism" EXACT []
synonym: "PAPS metabolic process" EXACT []
synonym: "PAPS metabolism" EXACT []
synonym: "phosphoadenosine phosphosulfate metabolic process" EXACT []
synonym: "phosphoadenosine phosphosulfate metabolism" EXACT []
xref: MetaCyc:PWY-5340
xref: Reactome:REACT_101365 "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate, Caenorhabditis elegans"
xref: Reactome:REACT_104279 "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate, Canis familiaris"
xref: Reactome:REACT_105414 "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate, Gallus gallus"
xref: Reactome:REACT_105791 "Cytosolic sulfonation of small molecules, Mus musculus"
xref: Reactome:REACT_106211 "Cytosolic sulfonation of small molecules, Caenorhabditis elegans"
xref: Reactome:REACT_106483 "Cytosolic sulfonation of small molecules, Bos taurus"
xref: Reactome:REACT_107127 "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_108586 "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate, Rattus norvegicus"
xref: Reactome:REACT_108591 "Cytosolic sulfonation of small molecules, Danio rerio"
xref: Reactome:REACT_110074 "Cytosolic sulfonation of small molecules, Sus scrofa"
xref: Reactome:REACT_114637 "Cytosolic sulfonation of small molecules, Escherichia coli"
xref: Reactome:REACT_28278 "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate, Xenopus tropicalis"
xref: Reactome:REACT_32292 "Cytosolic sulfonation of small molecules, Dictyostelium discoideum"
xref: Reactome:REACT_32764 "Cytosolic sulfonation of small molecules, Taeniopygia guttata"
xref: Reactome:REACT_33593 "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate, Drosophila melanogaster"
xref: Reactome:REACT_6763 "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate, Homo sapiens"
xref: Reactome:REACT_6913 "Cytosolic sulfonation of small molecules, Homo sapiens"
xref: Reactome:REACT_76997 "Cytosolic sulfonation of small molecules, Rattus norvegicus"
xref: Reactome:REACT_77119 "Cytosolic sulfonation of small molecules, Gallus gallus"
xref: Reactome:REACT_77194 "Cytosolic sulfonation of small molecules, Drosophila melanogaster"
xref: Reactome:REACT_78599 "Cytosolic sulfonation of small molecules, Oryza sativa"
xref: Reactome:REACT_78675 "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate, Mus musculus"
xref: Reactome:REACT_83375 "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate, Bos taurus"
xref: Reactome:REACT_84547 "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate, Sus scrofa"
xref: Reactome:REACT_85986 "Cytosolic sulfonation of small molecules, Canis familiaris"
xref: Reactome:REACT_90473 "Cytosolic sulfonation of small molecules, Xenopus tropicalis"
xref: Reactome:REACT_91830 "Cytosolic sulfonation of small molecules, Arabidopsis thaliana"
xref: Reactome:REACT_94834 "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate, Taeniopygia guttata"
xref: Reactome:REACT_95761 "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate, Danio rerio"
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0009150 ! purine ribonucleotide metabolic process
is_a: GO:0034035 ! purine ribonucleoside bisphosphate metabolic process
is_a: GO:0043436 ! oxoacid metabolic process
is_a: GO:0046128 ! purine ribonucleoside metabolic process

[Term]
id: GO:0050428
name: 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems." [ISBN:0198506732]
subset: gosubset_prok
synonym: "3'-phosphoadenosine 5'-phosphosulfate anabolism" EXACT []
synonym: "3'-phosphoadenosine 5'-phosphosulfate biosynthesis" EXACT []
synonym: "3'-phosphoadenosine 5'-phosphosulfate formation" EXACT []
synonym: "3'-phosphoadenosine 5'-phosphosulfate synthesis" EXACT []
synonym: "3'-phosphoadenosine 5'-phosphosulphate biosynthesis" EXACT []
synonym: "3'-phosphoadenosine 5'-phosphosulphate biosynthetic process" EXACT []
synonym: "3'-phosphoadenylyl-sulfate biosynthesis" EXACT []
synonym: "3'-phosphoadenylyl-sulfate biosynthetic process" EXACT []
synonym: "adenosine 3'-phosphate 5'-phosphosulfate biosynthesis" EXACT []
synonym: "adenosine 3'-phosphate 5'-phosphosulfate biosynthetic process" EXACT []
synonym: "PAPS biosynthesis" EXACT []
synonym: "PAPS biosynthetic process" EXACT []
synonym: "phosphoadenosine phosphosulfate biosynthesis" EXACT []
synonym: "phosphoadenosine phosphosulfate biosynthetic process" EXACT []
xref: Reactome:REACT_101203 "Formation of PAPS, Sus scrofa"
xref: Reactome:REACT_104357 "Formation of PAPS, Mus musculus"
xref: Reactome:REACT_106490 "Formation of PAPS, Taeniopygia guttata"
xref: Reactome:REACT_106506 "Formation of PAPS, Oryza sativa"
xref: Reactome:REACT_114402 "Formation of PAPS, Escherichia coli"
xref: Reactome:REACT_28489 "Formation of PAPS, Caenorhabditis elegans"
xref: Reactome:REACT_30373 "Formation of PAPS, Bos taurus"
xref: Reactome:REACT_31531 "Formation of PAPS, Danio rerio"
xref: Reactome:REACT_6840 "Formation of PAPS, Homo sapiens"
xref: Reactome:REACT_81356 "Formation of PAPS, Rattus norvegicus"
xref: Reactome:REACT_82544 "Formation of PAPS, Canis familiaris"
xref: Reactome:REACT_82624 "Formation of PAPS, Gallus gallus"
xref: Reactome:REACT_82760 "Formation of PAPS, Xenopus tropicalis"
xref: Reactome:REACT_90799 "Formation of PAPS, Drosophila melanogaster"
xref: Reactome:REACT_92258 "Formation of PAPS, Arabidopsis thaliana"
is_a: GO:0009152 ! purine ribonucleotide biosynthetic process
is_a: GO:0034036 ! purine ribonucleoside bisphosphate biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:0046129 ! purine ribonucleoside biosynthetic process
is_a: GO:0050427 ! 3'-phosphoadenosine 5'-phosphosulfate metabolic process

[Term]
id: GO:0050429
name: calcium-dependent phospholipase C activity
namespace: molecular_function
def: "Catalysis of the reaction: a phosphatidylcholine + H2O = 1,2-diacylglycerol + choline phosphate. This reaction requires Ca2+." [EC:3.1.4.3]
is_a: GO:0004629 ! phospholipase C activity

[Term]
id: GO:0050431
name: transforming growth factor beta binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with TGF-beta, transforming growth factor beta, a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types." [ISBN:0198506732]
synonym: "TGF-beta binding" EXACT []
synonym: "TGFbeta binding" EXACT []
synonym: "transforming growth factor beta ligand binding to type I receptor" RELATED []
synonym: "transforming growth factor beta ligand binding to type II receptor" RELATED []
is_a: GO:0019838 ! growth factor binding
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0050432
name: catecholamine secretion
namespace: biological_process
def: "The regulated release of catecholamines by a cell. The catecholamines are a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:ai, GOC:ef]
is_a: GO:0032940 ! secretion by cell
is_a: GO:0051937 ! catecholamine transport

[Term]
id: GO:0050433
name: regulation of catecholamine secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of catecholamines." [GOC:ai]
is_a: GO:0051952 ! regulation of amine transport
is_a: GO:1903530 ! regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050432 ! catecholamine secretion
relationship: regulates GO:0050432 ! catecholamine secretion

[Term]
id: GO:0050434
name: positive regulation of viral transcription
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of viral transcription." [GOC:ai]
synonym: "activation of viral transcription" NARROW []
synonym: "stimulation of viral transcription" NARROW []
synonym: "up regulation of viral transcription" EXACT []
synonym: "up-regulation of viral transcription" EXACT []
synonym: "upregulation of viral transcription" EXACT []
xref: Reactome:REACT_6162 "Tat-mediated elongation of the HIV-1 transcript, Homo sapiens"
is_a: GO:0010628 ! positive regulation of gene expression
is_a: GO:0046782 ! regulation of viral transcription
is_a: GO:1902680 ! positive regulation of RNA biosynthetic process
is_a: GO:1903902 ! positive regulation of viral life cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0019083 ! viral transcription
relationship: positively_regulates GO:0019083 ! viral transcription

[Term]
id: GO:0050435
name: beta-amyloid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving beta-amyloid, a glycoprotein associated with Alzheimer's disease, and its precursor, amyloid precursor protein (APP)." [GOC:ai]
subset: gosubset_prok
synonym: "beta-amyloid metabolism" EXACT []
is_a: GO:0006518 ! peptide metabolic process

[Term]
id: GO:0050436
name: microfibril binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a microfibril, any small fibril occurring in biological material." [GOC:ai]
comment: See also the cellular component term 'microfibril ; GO:0001527'.
is_a: GO:0005488 ! binding

[Term]
id: GO:0050437
name: (-)-endo-fenchol synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranyl diphosphate + H(2)O = (-)-endo-fenchol + diphosphate." [EC:4.2.3.10, RHEA:20568]
synonym: "(-)-endo-fenchol cyclase activity" EXACT [EC:4.2.3.10]
synonym: "geranyl pyrophosphate:(-)-endo-fenchol cyclase activity" EXACT [EC:4.2.3.10]
synonym: "geranyl-diphosphate diphosphate-lyase [cyclizing, (-)-endo-fenchol-forming]" RELATED [EC:4.2.3.10]
xref: EC:4.2.3.10
xref: KEGG:R02004
xref: MetaCyc:4.2.3.10-RXN
xref: RHEA:20568
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0050438
name: 2-ethylmalate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxobutanate + acetyl-CoA + H(2)O = (R)-2-ethylmalate + CoA + H(+)." [EC:2.3.3.6, RHEA:23043]
synonym: "(R)-2-ethylmalate 2-oxobutanoyl-lyase (CoA-acetylating) activity" EXACT [EC:2.3.3.6]
synonym: "2-ethylmalate-3-hydroxybutanedioate synthase activity" EXACT [EC:2.3.3.6]
synonym: "acetyl-CoA:2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)" EXACT [EC:2.3.3.6]
synonym: "propylmalate synthase activity" EXACT [EC:2.3.3.6]
synonym: "propylmalic synthase activity" EXACT [EC:2.3.3.6]
xref: EC:2.3.3.6
xref: KEGG:R00998
xref: MetaCyc:2-ETHYLMALATE-SYNTHASE-RXN
xref: RHEA:23043
is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

[Term]
id: GO:0050439
name: 2-hydroxy-3-oxoadipate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + glyoxylate + H(+) = 2-hydroxy-3-oxoadipate + CO(2)." [EC:2.2.1.5, RHEA:14344]
synonym: "2-hydroxy-3-oxoadipate glyoxylate-lyase (carboxylating) activity" EXACT [EC:2.2.1.5]
synonym: "2-hydroxy-3-oxoadipate synthetase activity" EXACT [EC:2.2.1.5]
synonym: "2-oxoglutarate:glyoxylate succinaldehydetransferase (decarboxylating)" EXACT [EC:2.2.1.5]
synonym: "alpha-ketoglutaric-glyoxylic carboligase activity" EXACT [EC:2.2.1.5]
synonym: "oxoglutarate: glyoxylate carboligase activity" EXACT [EC:2.2.1.5]
synonym: "oxoglutarate:glyoxylate carboligase activity" EXACT [EC:2.2.1.5]
xref: EC:2.2.1.5
xref: KEGG:R00474
xref: MetaCyc:2-HYDROXY-3-OXOADIPATE-SYNTHASE-RXN
xref: RHEA:14344
is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups

[Term]
id: GO:0050440
name: 2-methylcitrate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + oxaloacetate + propanoyl-CoA = (2R,3S)-2-methylcitrate + CoA + H(+)." [EC:2.3.3.5, RHEA:23783]
subset: gosubset_prok
synonym: "2-methylcitrate oxaloacetate-lyase activity" EXACT [EC:2.3.3.5]
synonym: "MCS activity" EXACT [EC:2.3.3.5]
synonym: "methylcitrate synthase activity" EXACT [EC:2.3.3.5]
synonym: "methylcitrate synthetase activity" EXACT [EC:2.3.3.5]
synonym: "propanoyl-CoA:oxaloacetate C-propanoyltransferase (thioester-hydrolysing, 1-carboxyethyl-forming)" EXACT [EC:2.3.3.5]
xref: EC:2.3.3.5
xref: KEGG:R00931
xref: MetaCyc:2-METHYLCITRATE-SYNTHASE-RXN
xref: RHEA:23783
is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

[Term]
id: GO:0050441
name: 3-ethylmalate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: butanoyl-CoA + glyoxylate + H(2)O = 3-ethylmalate + CoA + H(+)." [EC:2.3.3.7, RHEA:10503]
synonym: "2-ethyl-3-hydroxybutanedioate synthase activity" EXACT [EC:2.3.3.7]
synonym: "3-ethylmalate glyoxylate-lyase (CoA-butanoylating) activity" EXACT [EC:2.3.3.7]
synonym: "butanoyl-CoA:glyoxylate C-butanoyltransferase (thioester-hydrolysing, 1-carboxypropyl-forming)" EXACT [EC:2.3.3.7]
xref: EC:2.3.3.7
xref: KEGG:R01180
xref: MetaCyc:3-ETHYLMALATE-SYNTHASE-RXN
xref: RHEA:10503
is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

[Term]
id: GO:0050442
name: 3-propylmalate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: glyoxylate + H(2)O + pentanoyl-CoA = 3-propylmalate + CoA + H(+)." [EC:2.3.3.12, RHEA:14460]
synonym: "3-(n-propyl)-malate synthase activity" EXACT [EC:2.3.3.12]
synonym: "3-propylmalate glyoxylate-lyase (CoA-pentanoylating) activity" EXACT [EC:2.3.3.12]
synonym: "beta-n-propylmalate synthase activity" EXACT [EC:2.3.3.12]
synonym: "N-propylmalate synthase activity" EXACT [EC:2.3.3.12]
synonym: "pentanoyl-CoA:glyoxylate C-pentanoyltransferase (thioester-hydrolysing, 1-carboxybutyl-forming)" EXACT [EC:2.3.3.12]
xref: EC:2.3.3.12
xref: KEGG:R03040
xref: MetaCyc:3-PROPYLMALATE-SYNTHASE-RXN
xref: RHEA:14460
is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

[Term]
id: GO:0050444
name: aquacobalamin reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 cob(II)alamin + NADP+ = 2 aquacob(III)alamin + NADPH + H+." [EC:1.16.1.5, MetaCyc:AQUACOBALAMIN-REDUCTASE-NADPH-RXN]
synonym: "aquacobalamin (reduced nicotinamide adenine dinucleotide phosphate) activity" EXACT [EC:1.16.1.5]
synonym: "aquacobalamin (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.16.1.5]
synonym: "cob(II)alamin:NADP+ oxidoreductase activity" EXACT [EC:1.16.1.5]
synonym: "NADPH-linked aquacobalamin reductase activity" EXACT [EC:1.16.1.5]
synonym: "NADPH2:aquacob(III)alamin oxidoreductase activity" EXACT [EC:1.16.1.5]
synonym: "NADPH:aquacob(III)alamin oxidoreductase activity" EXACT [EC:1.16.1.5]
xref: EC:1.16.1.5
xref: MetaCyc:AQUACOBALAMIN-REDUCTASE-NADPH-RXN
xref: RHEA:20755
is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor

[Term]
id: GO:0050445
name: asparagusate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-mercapto-2-mercaptomethylpropanoate + NAD(+) = asparagusate + H(+) + NADH." [EC:1.8.1.11, RHEA:14884]
synonym: "3-mercapto-2-mercaptomethylpropanoate:NAD+ oxidoreductase activity" EXACT [EC:1.8.1.11]
synonym: "asparagusate dehydrogenase activity" EXACT [EC:1.8.1.11]
synonym: "asparagusate reductase (NADH) activity" EXACT []
synonym: "asparagusate reductase (NADH2)" EXACT [EC:1.8.1.11]
synonym: "asparagusic dehydrogenase activity" EXACT [EC:1.8.1.11]
synonym: "NADH2:asparagusate oxidoreductase activity" EXACT [EC:1.8.1.11]
synonym: "NADH:asparagusate oxidoreductase activity" EXACT [EC:1.8.1.11]
xref: EC:1.8.1.11
xref: KEGG:R03761
xref: MetaCyc:ASPARAGUSATE-REDUCTASE-NADH-RXN
xref: RHEA:14884
is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor

[Term]
id: GO:0050446
name: azobenzene reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: N,N-dimethyl-1,4-phenylenediamine + aniline + NADP+ = 4-(dimethylamino)azobenzene + NADPH + H+." [EC:1.7.1.6, MetaCyc:AZOBENZENE-REDUCTASE-RXN]
synonym: "azo reductase activity" BROAD [EC:1.7.1.6]
synonym: "azo-dye reductase activity" BROAD [EC:1.7.1.6]
synonym: "azoreductase activity" BROAD [EC:1.7.1.6]
synonym: "dibromopropylaminophenylazobenzoic azoreductase activity" EXACT [EC:1.7.1.6]
synonym: "dimethylaminobenzene reductase activity" EXACT [EC:1.7.1.6]
synonym: "methyl red azoreductase activity" NARROW [EC:1.7.1.6]
synonym: "N,N-dimethyl-1,4-phenylenediamine, aniline:NADP+ oxidoreductase activity" EXACT [EC:1.7.1.6]
synonym: "N,N-dimethyl-4-phenylazoaniline azoreductase activity" EXACT [EC:1.7.1.6]
synonym: "NAD(P)H:1-(4'-sulfophenylazo)-2-naphthol oxidoreductase activity" EXACT [EC:1.7.1.6]
synonym: "NADPH-dependent azoreductase activity" BROAD [EC:1.7.1.6]
synonym: "NADPH2-dependent azoreductase activity" EXACT [EC:1.7.1.6]
synonym: "NADPH2:4-(dimethylamino)azobenzene oxidoreductase activity" EXACT [EC:1.7.1.6]
synonym: "NADPH:4-(dimethylamino)azobenzene oxidoreductase activity" EXACT [EC:1.7.1.6]
synonym: "NC-reductase activity" NARROW [EC:1.7.1.6]
synonym: "new coccine (NC)-reductase" RELATED [EC:1.7.1.6]
synonym: "New coccine (NC)-reductase activity" NARROW [EC:1.7.1.6]
synonym: "nicotinamide adenine dinucleotide (phosphate) azoreductase activity" EXACT [EC:1.7.1.6]
synonym: "orange I azoreductase activity" NARROW [EC:1.7.1.6]
synonym: "orange II azoreductase activity" NARROW [EC:1.7.1.6]
synonym: "p-aminoazobenzene reductase activity" EXACT [EC:1.7.1.6]
synonym: "p-dimethylaminoazobenzene azoreductase activity" EXACT [EC:1.7.1.6]
xref: EC:1.7.1.6
xref: MetaCyc:AZOBENZENE-REDUCTASE-RXN
xref: RHEA:16272
xref: UM-BBD_reactionID:r0808
is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor

[Term]
id: GO:0050447
name: zeatin 9-aminocarboxyethyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: O-acetyl-L-serine + zeatin = L-lupinate + acetate + H(+)." [EC:2.5.1.50, RHEA:17336]
synonym: "3-O-acetyl-L-serine:zeatin 2-amino-2-carboxyethyltransferase activity" EXACT [EC:2.5.1.50]
synonym: "beta-(9-cytokinin)-alanine synthase activity" EXACT []
synonym: "beta-(9-cytokinin)alanine synthase activity" EXACT [EC:2.5.1.50]
synonym: "lupinate synthetase activity" EXACT [EC:2.5.1.50]
synonym: "lupinic acid synthase activity" EXACT [EC:2.5.1.50]
synonym: "lupinic acid synthetase activity" EXACT [EC:2.5.1.50]
synonym: "O-acetyl-L-serine acetate-lyase (adding N(6)-substituted adenine) activity" EXACT [EC:2.5.1.50]
synonym: "O-acetyl-L-serine acetate-lyase (adding N6-substituted adenine)" EXACT [EC:2.5.1.50]
synonym: "O3-acetyl-L-serine:zeatin 2-amino-2-carboxyethyltransferase activity" EXACT [EC:2.5.1.50]
xref: EC:2.5.1.50
xref: KEGG:R03133
xref: MetaCyc:BETA-9-CYTOKININ-ALANINE-SYNTHASE-RXN
xref: RHEA:17336
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0050448
name: beta-cyclopiazonate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-cyclopiazonate + A = alpha-cyclopiazonate + AH(2)." [EC:1.21.99.1, RHEA:14526]
synonym: "b-cyclopiazonate dehydrogenase activity" EXACT []
synonym: "beta-cyclopiazonate oxidocyclase activity" EXACT [EC:1.21.99.1]
synonym: "beta-cyclopiazonate:(acceptor) oxidoreductase (cyclizing)" EXACT [EC:1.21.99.1]
synonym: "beta-cyclopiazonate:acceptor oxidoreductase (cyclizing)" EXACT [EC:1.21.99.1]
synonym: "beta-cyclopiazonic oxidocyclase activity" EXACT [EC:1.21.99.1]
xref: EC:1.21.99.1
xref: KEGG:R04080
xref: MetaCyc:BETA-CYCLOPIAZONATE-DEHYDROGENASE-RXN
xref: RHEA:14526
is_a: GO:0046992 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond

[Term]
id: GO:0050449
name: casbene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = casbene + diphosphate." [EC:4.2.3.8, RHEA:14904]
synonym: "casbene synthetase activity" EXACT [EC:4.2.3.8]
synonym: "geranylgeranyl-diphosphate diphosphate-lyase (cyclizing)" EXACT [EC:4.2.3.8]
synonym: "geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, casbene-forming)" EXACT [EC:4.2.3.8]
xref: EC:4.2.3.8
xref: KEGG:R02064
xref: MetaCyc:CASBENE-SYNTHASE-RXN
xref: RHEA:14904
is_a: GO:0010333 ! terpene synthase activity

[Term]
id: GO:0050450
name: citrate (Re)-synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the re-face of oxaloacetate; acetyl-CoA provides the two carbon atoms of the pro-R carboxymethyl group." [EC:2.3.3.3, ISBN:0121227073, MetaCyc:CITRATE-RE-SYNTHASE-RXN]
synonym: "(R)-citrate synthase activity" EXACT [EC:2.3.3.3]
synonym: "acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-R)-carboxymethyl-forming]" RELATED [EC:2.3.3.3]
synonym: "citrate oxaloacetate-lyase ((pro-3R)-CH(2)COO(-)->acetyl-CoA) activity" EXACT [EC:2.3.3.3]
synonym: "citrate oxaloacetate-lyase [(pro-3R)-CH2COO-rightacetyl-CoA]" RELATED [EC:2.3.3.3]
synonym: "Re-citrate-synthase activity" EXACT [EC:2.3.3.3]
xref: EC:2.3.3.3
xref: MetaCyc:CITRATE-RE-SYNTHASE-RXN
is_a: GO:0036440 ! citrate synthase activity

[Term]
id: GO:0050451
name: CoA-disulfide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 CoA + NAD+ = CoA-disulfide + NADH + H+." [EC:1.8.1.14, MetaCyc:COA-DISULFIDE-REDUCTASE-NADH-RXN]
synonym: "CoA-disulfide reductase (NAD(P)H) activity" RELATED [EC:1.8.1.14]
synonym: "CoA-disulfide reductase (NADH) activity" EXACT []
synonym: "CoA-disulfide reductase (NADH2)" EXACT [EC:1.8.1.14]
synonym: "CoA-disulfide reductase [NAD(P)H]" RELATED [EC:1.8.1.14]
synonym: "CoA-disulphide reductase activity" EXACT []
synonym: "CoA:NAD(P)+ oxidoreductase activity" EXACT [EC:1.8.1.14]
synonym: "CoA:NAD+ oxidoreductase activity" EXACT [EC:1.8.1.14]
synonym: "CoADR activity" EXACT [EC:1.8.1.14]
synonym: "coenzyme A disulfide reductase activity" EXACT [EC:1.8.1.14]
synonym: "NADH2:CoA-disulfide oxidoreductase activity" EXACT [EC:1.8.1.14]
synonym: "NADH:CoA-disulfide oxidoreductase activity" EXACT [EC:1.8.1.14]
xref: EC:1.8.1.14
xref: MetaCyc:COA-DISULFIDE-REDUCTASE-NADH-RXN
is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor

[Term]
id: GO:0050452
name: CoA-glutathione reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: CoA + glutathione + NADP+ = CoA-glutathione + NADPH + H+." [EC:1.8.1.10, MetaCyc:COA-GLUTATHIONE-REDUCTASE-NADPH-RXN]
synonym: "CoA-glutathione reductase (NADPH) activity" EXACT []
synonym: "coenzyme A disulfide-glutathione reductase activity" EXACT [EC:1.8.1.10]
synonym: "coenzyme A glutathione disulfide reductase activity" EXACT [EC:1.8.1.10]
synonym: "glutathione:NADP+ oxidoreductase (CoA-acylating)" EXACT [EC:1.8.1.10]
synonym: "NADPH-dependent coenzyme A-SS-glutathione reductase activity" EXACT [EC:1.8.1.10]
synonym: "NADPH2:CoA-glutathione oxidoreductase activity" EXACT [EC:1.8.1.10]
synonym: "NADPH:CoA-glutathione oxidoreductase activity" EXACT [EC:1.8.1.10]
xref: EC:1.8.1.10
xref: MetaCyc:COA-GLUTATHIONE-REDUCTASE-NADPH-RXN
xref: RHEA:14620
is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor

[Term]
id: GO:0050453
name: cob(II)alamin reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 cob(I)alamin + H(+) + NAD(+) = 2 cob(II)alamin + NADH." [EC:1.16.1.4, RHEA:17484]
synonym: "B(12r) reductase activity" EXACT [EC:1.16.1.4]
synonym: "B12r reductase activity" EXACT [EC:1.16.1.4]
synonym: "cob(I)alamin:NAD+ oxidoreductase activity" EXACT [EC:1.16.1.4]
synonym: "NADH2:cob(II)alamin oxidoreductase activity" EXACT [EC:1.16.1.4]
synonym: "NADH:cob(II)alamin oxidoreductase activity" EXACT [EC:1.16.1.4]
synonym: "vitamin B(12r) reductase activity" EXACT [EC:1.16.1.4]
synonym: "vitamin B12 reductase activity" EXACT []
synonym: "vitamin B12 reduction" RELATED []
synonym: "vitamin B12r reductase activity" EXACT [EC:1.16.1.4]
xref: EC:1.16.1.4
xref: KEGG:R00099
xref: MetaCyc:COBIIALAMIN-REDUCTASE-RXN
xref: RHEA:17484
is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor

[Term]
id: GO:0050454
name: coenzyme F420 hydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: coenzyme F420 + H(2) + H(+) = reduced coenzyme F420." [EC:1.12.98.1, RHEA:23763]
subset: gosubset_prok
synonym: "8-hydroxy-5-deazaflavin-reducing hydrogenase activity" EXACT [EC:1.12.98.1]
synonym: "coenzyme F420-dependent hydrogenase activity" EXACT [EC:1.12.98.1]
synonym: "F420-reducing hydrogenase activity" EXACT [EC:1.12.98.1]
synonym: "hydrogen:coenzyme F420 oxidoreductase activity" EXACT [EC:1.12.98.1]
xref: EC:1.12.98.1
xref: KEGG:R03025
xref: MetaCyc:COENZYME-F420-HYDROGENASE-RXN
xref: RHEA:23763
is_a: GO:0046995 ! oxidoreductase activity, acting on hydrogen as donor, with other known acceptors

[Term]
id: GO:0050455
name: columbamine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 columbamine + O(2) = 2 berberine + 2 H(2)O." [EC:1.21.3.2, RHEA:23567]
synonym: "berberine synthase activity" EXACT [EC:1.21.3.2]
synonym: "columbamine:oxygen oxidoreductase (cyclizing)" EXACT [EC:1.21.3.2]
xref: EC:1.21.3.2
xref: KEGG:R00044
xref: MetaCyc:COLUMBAMINE-OXIDASE-RXN
xref: RHEA:23567
is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor

[Term]
id: GO:0050456
name: cystine reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 L-cysteine + NAD(+) = L-cystine + H(+) + NADH." [EC:1.8.1.6, RHEA:20600]
subset: gosubset_prok
synonym: "cystine reductase (NADH) activity" EXACT [EC:1.8.1.6]
synonym: "cystine reductase (NADH2)" EXACT [EC:1.8.1.6]
synonym: "L-cysteine:NAD+ oxidoreductase" EXACT [EC:1.8.1.6]
synonym: "NADH-dependent cystine reductase activity" EXACT [EC:1.8.1.6]
synonym: "NADH2:L-cystine oxidoreductase" EXACT [EC:1.8.1.6]
synonym: "NADH:L-cystine oxidoreductase activity" EXACT [EC:1.8.1.6]
xref: EC:1.8.1.6
xref: KEGG:R00892
xref: MetaCyc:CYSTINE-REDUCTASE-NADH-RXN
xref: RHEA:20600
is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor

[Term]
id: GO:0050457
name: decylcitrate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + lauroyl-CoA + oxaloacetate = (2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate + CoA + H(+)." [EC:2.3.3.2, RHEA:16608]
synonym: "(2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate oxaloacetate-lyase (CoA- acylating) activity" EXACT [EC:2.3.3.2]
synonym: "(2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate oxaloacetate-lyase (CoA-acylating)" EXACT [EC:2.3.3.2]
synonym: "2-decylcitrate synthase activity" EXACT [EC:2.3.3.2]
synonym: "dodecanoyl-CoA:oxaloacetate C-dodecanoyltransferase (thioester-hydrolysing, 1-carboxyundecyl-forming)" EXACT [EC:2.3.3.2]
xref: EC:2.3.3.2
xref: KEGG:R03735
xref: MetaCyc:DECYLCITRATE-SYNTHASE-RXN
xref: RHEA:16608
is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

[Term]
id: GO:0050458
name: decylhomocitrate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + H(2)O + lauroyl-CoA = (3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA + H(+)." [EC:2.3.3.4, RHEA:10367]
synonym: "2-decylhomocitrate synthase activity" EXACT [EC:2.3.3.4]
synonym: "3-hydroxytetradecane-1,3,4-tricarboxylate 2-oxoglutarate-lyase (CoA- acylating) activity" EXACT [EC:2.3.3.4]
synonym: "3-hydroxytetradecane-1,3,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acylating)" EXACT [EC:2.3.3.4]
synonym: "dodecanoyl-CoA:2-oxoglutarate C-dodecanoyltransferase (thioester-hydrolysing, 1-carboxyundecyl-forming)" EXACT [EC:2.3.3.4]
xref: EC:2.3.3.4
xref: KEGG:R03859
xref: MetaCyc:DECYLHOMOCITRATE-SYNTHASE-RXN
xref: RHEA:10367
is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

[Term]
id: GO:0050459
name: ethanolamine-phosphate phospho-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + phosphoethanolamine = acetaldehyde + NH(4)(+) + phosphate." [EC:4.2.3.2, RHEA:17892]
synonym: "amino alcohol O-phosphate phospholyase activity" BROAD [EC:4.2.3.2]
synonym: "ethanolamine-phosphate phospho-lyase (deaminating)" EXACT [EC:4.2.3.2]
synonym: "ethanolamine-phosphate phospho-lyase (deaminating; acetaldehyde-forming)" EXACT [EC:4.2.3.2]
synonym: "O-phosphoethanolamine-phospholyase activity" EXACT [EC:4.2.3.2]
synonym: "O-phosphorylethanol-amine phospho-lyase activity" EXACT [EC:4.2.3.2]
xref: EC:4.2.3.2
xref: KEGG:R00748
xref: MetaCyc:ETHANOLAMINE-PHOSPHATE-PHOSPHO-LYASE-RXN
xref: RHEA:17892
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0050460
name: hydroxylamine reductase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: NH3 + NAD+ + H2O = hydroxylamine + NADH + H+." [EC:1.7.1.10, MetaCyc:HYDROXYLAMINE-REDUCTASE-NADH-RXN]
synonym: "ammonium dehydrogenase activity" EXACT [EC:1.7.1.10]
synonym: "ammonium:NAD+ oxidoreductase activity" EXACT [EC:1.7.1.10]
synonym: "hydroxylamine reductase (NADH2)" EXACT [EC:1.7.1.10]
synonym: "N-hydroxy amine reductase activity" EXACT [EC:1.7.1.10]
synonym: "NADH-hydroxylamine reductase activity" EXACT [EC:1.7.1.10]
synonym: "NADH2:hydroxylamine oxidoreductase activity" EXACT [EC:1.7.1.10]
synonym: "NADH:hydroxylamine oxidoreductase activity" EXACT [EC:1.7.1.10]
xref: EC:1.7.1.10
xref: MetaCyc:HYDROXYLAMINE-REDUCTASE-NADH-RXN
xref: RHEA:20584
is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor

[Term]
id: GO:0050461
name: L-mimosine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,4-dihydroxypyridine + O-acetyl-L-serine = 3-(3,4-dihydroxypyridinium-1-yl)-L-alanine + acetate." [EC:2.5.1.52, RHEA:12696]
synonym: "3-O-acetyl-L-serine:3,4-dihydroxypyridine 1-(2-amino-2-carboxyethyl)transferase activity" EXACT [EC:2.5.1.52]
synonym: "O(3)-acetyl-L-serine acetate-lyase (adding 3,4-dihydroxypyridin-1-yl) activity" EXACT [EC:2.5.1.52]
synonym: "O3-acetyl-L-serine acetate-lyase (adding 3,4-dihydroxypyridin-1-yl)" EXACT [EC:2.5.1.52]
synonym: "O3-acetyl-L-serine:3,4-dihydroxypyridine 1-(2-amino-2-carboxyethyl)transferase activity" EXACT [EC:2.5.1.52]
xref: EC:2.5.1.52
xref: KEGG:R04091
xref: MetaCyc:RXN-7461
xref: RHEA:12696
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0050462
name: N-acetylneuraminate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphoenolpyruvate + N-acetyl-D-mannosamine + H2O = phosphate + N-acetylneuraminate." [EC:2.5.1.56, MetaCyc:N-ACETYLNEURAMINATE-SYNTHASE-RXN]
synonym: "(NANA)condensing enzyme activity" EXACT [EC:2.5.1.56]
synonym: "N-acetylneuraminate pyruvate-lyase (pyruvate-phosphorylating) activity" EXACT [EC:2.5.1.56]
synonym: "N-acetylneuraminic acid synthase activity" EXACT [EC:2.5.1.56]
synonym: "NeuAc synthase activity" EXACT [EC:2.5.1.56]
synonym: "phosphoenolpyruvate:N-acetyl-D-mannosamine C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)" EXACT [EC:2.5.1.56]
xref: EC:2.5.1.56
xref: MetaCyc:N-ACETYLNEURAMINATE-SYNTHASE-RXN
xref: RHEA:19276
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0050463
name: nitrate reductase [NAD(P)H] activity
namespace: molecular_function
def: "Catalysis of the reaction: nitrite + NAD(P)+ + H2O = nitrate + NAD(P)H + H+." [EC:1.7.1.2, MetaCyc:NITRATE-REDUCTASE-NADPH-RXN]
synonym: "assimilatory NAD(P)H-nitrate reductase activity" RELATED [EC:1.7.1.2]
synonym: "assimilatory nitrate reductase activity" RELATED [EC:1.7.1.2]
synonym: "NAD(P)H bispecific nitrate reductase activity" EXACT [EC:1.7.1.2]
synonym: "NAD(P)H-nitrate reductase activity" EXACT [EC:1.7.1.2]
synonym: "NAD(P)H2:nitrate oxidoreductase activity" EXACT [EC:1.7.1.2]
synonym: "NAD(P)H:nitrate oxidoreductase activity" EXACT [EC:1.7.1.2]
synonym: "nitrate reductase (reduced nicotinamide adenine dinucleotide (phosphate)) activity" EXACT [EC:1.7.1.2]
synonym: "nitrate reductase [NAD(P)H2]" RELATED [EC:1.7.1.2]
synonym: "nitrate reductase NAD(P)H activity" EXACT [EC:1.7.1.2]
synonym: "nitrite:NAD(P)+ oxidoreductase activity" EXACT [EC:1.7.1.2]
xref: EC:1.7.1.2
is_a: GO:0008940 ! nitrate reductase activity
is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor

[Term]
id: GO:0050464
name: nitrate reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: nitrite + NADP+ + H2O = nitrate + NADPH + H+." [EC:1.7.1.3, MetaCyc:NITRATE-REDUCTASE-NADPH-RXN]
synonym: "assimilatory NADPH-nitrate reductase activity" EXACT [EC:1.7.1.3]
synonym: "assimilatory nitrate reductase activity" BROAD [EC:1.7.1.3]
synonym: "assimilatory reduced nicotinamide adenine dinucleotide phosphate-nitrate reductase activity" EXACT [EC:1.7.1.3]
synonym: "NADPH-nitrate reductase activity" EXACT [EC:1.7.1.3]
synonym: "NADPH:nitrate oxidoreductase activity" EXACT [EC:1.7.1.3]
synonym: "NADPH:nitrate reductase activity" EXACT [EC:1.7.1.3]
synonym: "nitrate reductase (NADPH(2)) activity" EXACT [EC:1.7.1.3]
synonym: "nitrate reductase (NADPH2)" EXACT [EC:1.7.1.3]
synonym: "nitrite:NADP+ oxidoreductase activity" EXACT [EC:1.7.1.3]
synonym: "triphosphopyridine nucleotide-nitrate reductase activity" EXACT [EC:1.7.1.3]
xref: EC:1.7.1.3
xref: MetaCyc:NITRATE-REDUCTASE-NADPH-RXN
xref: RHEA:19064
is_a: GO:0008940 ! nitrate reductase activity
is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor

[Term]
id: GO:0050465
name: nitroquinoline-N-oxide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-(hydroxyamino)quinoline N-oxide + 2 NAD(P)+ + H2O = 4-nitroquinoline N-oxide + 2 NAD(P)H + 2 H+." [EC:1.7.1.9, MetaCyc:1.7.1.9-RXN]
synonym: "4-(hydroxyamino)quinoline N-oxide:NADP+ oxidoreductase activity" EXACT [EC:1.7.1.9]
synonym: "4-nitroquinoline 1-oxide reductase activity" EXACT [EC:1.7.1.9]
synonym: "4NQO reductase activity" EXACT [EC:1.7.1.9]
synonym: "NAD(P)H2:4-nitroquinoline-N-oxide oxidoreductase activity" EXACT [EC:1.7.1.9]
synonym: "NAD(P)H:4-nitroquinoline-N-oxide oxidoreductase activity" EXACT [EC:1.7.1.9]
xref: EC:1.7.1.9
xref: MetaCyc:1.7.1.9-RXN
is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor

[Term]
id: GO:0050466
name: obsolete oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with other acceptors
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y and the acceptor is not disulfide or oxygen." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with other acceptors" EXACT []
is_obsolete: true
consider: GO:0046992

[Term]
id: GO:0050467
name: pentalenene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + pentalenene." [EC:4.2.3.7, RHEA:18084]
subset: gosubset_prok
synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, pentalenene-forming)" EXACT [EC:4.2.3.7]
synonym: "2-trans,6-trans-farnesyldiphosphate diphosphate-lyase (cyclizing, pentalenene-forming)" EXACT [EC:4.2.3.7]
synonym: "pentalenene synthetase activity" EXACT [EC:4.2.3.7]
xref: EC:4.2.3.7
xref: KEGG:R02305
xref: MetaCyc:PENTALENENE-SYNTHASE-RXN
xref: RHEA:18084
is_a: GO:0010334 ! sesquiterpene synthase activity

[Term]
id: GO:0050468
name: reticuline oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-reticuline + O(2) = (S)-scoulerine + H(2)O(2) + H(+)." [EC:1.21.3.3, RHEA:19888]
synonym: "(S)-reticuline:oxygen oxidoreductase (methylene-bridge-forming)" EXACT [EC:1.21.3.3]
synonym: "BBE" RELATED [EC:1.21.3.3]
synonym: "berberine bridge enzyme activity" EXACT [EC:1.21.3.3]
synonym: "berberine-bridge-forming enzyme activity" EXACT [EC:1.21.3.3]
synonym: "tetrahydroprotoberberine synthase activity" EXACT [EC:1.21.3.3]
xref: EC:1.21.3.3
xref: KEGG:R03831
xref: MetaCyc:RETICULINE-OXIDASE-RXN
xref: RHEA:19888
is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor

[Term]
id: GO:0050469
name: sabinene-hydrate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranyl diphosphate + H(2)O = diphosphate + sabinene hydrate." [EC:4.2.3.11, RHEA:19568]
synonym: "geranyl-diphosphate diphosphate-lyase (cyclizing, sabinene-hydrate-forming)" EXACT [EC:4.2.3.11]
synonym: "sabinene hydrate cyclase activity" EXACT [EC:4.2.3.11]
xref: EC:4.2.3.11
xref: KEGG:R02006
xref: MetaCyc:4.2.3.11-RXN
xref: RHEA:19568
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0050470
name: trimethylamine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: trimethylamine + H2O + electron-transferring flavoprotein = dimethylamine + formaldehyde + reduced electron-transferring flavoprotein." [EC:1.5.8.2, MetaCyc:1.5.8.2-RXN]
subset: gosubset_prok
synonym: "TMADh activity" RELATED [EC:1.5.8.2]
synonym: "trimethylamine:electron-transferring flavoprotein oxidoreductase (demethylating)" EXACT [EC:1.5.8.2]
xref: EC:1.5.8.2
xref: MetaCyc:1.5.8.2-RXN
xref: UM-BBD_enzymeID:e0854
is_a: GO:0046997 ! oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor

[Term]
id: GO:0050471
name: uracilylalanine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: O3-acetyl-L-serine + uracil = 3-(uracil-1-yl)-L-alanine + acetate." [EC:2.5.1.53, MetaCyc:URACILYLALANINE-SYNTHASE-RXN]
synonym: "3-O-acetyl-L-serine:uracil 1-(2-amino-2-carboxyethyl)transferase activity" EXACT [EC:2.5.1.53]
synonym: "isowillardiine synthase activity" EXACT [EC:2.5.1.53]
synonym: "O(3)-acetyl-L-serine acetate-lyase (adding uracil) activity" EXACT [EC:2.5.1.53]
synonym: "O3-acetyl-L-serine acetate-lyase (adding uracil)" EXACT [EC:2.5.1.53]
synonym: "O3-acetyl-L-serine:uracil 1-(2-amino-2-carboxyethyl)transferase activity" EXACT [EC:2.5.1.53]
synonym: "Willardiine synthase activity" EXACT [EC:2.5.1.53]
xref: EC:2.5.1.53
xref: MetaCyc:URACILYLALANINE-SYNTHASE-RXN
xref: RHEA:11499
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0050472
name: zeatin reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: dihydrozeatin + NADP(+) = H(+) + NADPH + zeatin." [EC:1.3.1.69, RHEA:12760]
synonym: "dihydrozeatin:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.69]
xref: EC:1.3.1.69
xref: KEGG:R05702
xref: MetaCyc:ZEATIN-REDUCTASE-RXN
xref: RHEA:12760
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050473
name: arachidonate 15-lipoxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate." [EC:1.13.11.33]
subset: gosubset_prok
synonym: "15-lipoxygenase activity" EXACT [EC:1.13.11.33]
synonym: "arachidonate omega(6) lipoxygenase activity" EXACT [EC:1.13.11.33]
synonym: "arachidonate omega6 lipoxygenase activity" EXACT [EC:1.13.11.33]
synonym: "arachidonate:oxygen 15-oxidoreductase activity" EXACT [EC:1.13.11.33]
synonym: "linoleic acid omega6-lipoxygenase activity" EXACT [EC:1.13.11.33]
synonym: "omega6 lipoxygenase activity" EXACT [EC:1.13.11.33]
xref: EC:1.13.11.33
xref: MetaCyc:ARACHIDONATE-15-LIPOXYGENASE-RXN
xref: RHEA:16872
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0050474
name: (S)-norcoclaurine synthase activity
namespace: molecular_function
alt_id: GO:0050475
def: "Catalysis of the reaction: 4-(2-aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde = (S)-norcoclaurine + H2O." [EC:4.2.1.78]
synonym: "(S)-norlaudanosoline synthase activity" EXACT [EC:4.2.1.78]
synonym: "4-hydroxyphenylacetaldehyde hydro-lyase (adding dopamine)" EXACT [EC:4.2.1.78]
synonym: "4-hydroxyphenylacetaldehyde hydro-lyase [adding dopamine; (S)-norcoclaurine-forming]" RELATED [EC:4.2.1.78]
xref: EC:4.2.1.78
xref: MetaCyc:S-NORLAUDANOSOLINE-SYNTHASE-RXN
xref: RHEA:16176
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050476
name: acetylenedicarboxylate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + acetylenedicarboxylate = CO2 + pyruvate." [EC:4.1.1.78]
synonym: "acetylenedicarboxylate carboxy-lyase (pyruvate-forming)" EXACT [EC:4.1.1.78]
synonym: "acetylenedicarboxylate carboxy-lyase activity" EXACT [EC:4.1.1.78]
synonym: "acetylenedicarboxylate hydrase activity" EXACT [EC:4.1.1.78]
synonym: "acetylenedicarboxylate hydratase activity" EXACT [EC:4.1.1.78]
xref: EC:4.1.1.78
xref: MetaCyc:4.1.1.78-RXN
xref: RHEA:17736
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050477
name: acyl-lysine deacylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + N6-acyl-L-lysine = L-lysine + a carboxylate." [EC:3.5.1.17]
synonym: "6-N-acyl-L-lysine amidohydrolase activity" EXACT [EC:3.5.1.17]
synonym: "epsilon-lysine acylase activity" EXACT [EC:3.5.1.17]
synonym: "N6-acyl-L-lysine amidohydrolase activity" EXACT [EC:3.5.1.17]
xref: EC:3.5.1.17
xref: MetaCyc:ACYL-LYSINE-DEACYLASE-RXN
xref: RHEA:24551
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050478
name: anthranilate 3-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,6,7,8-tetrahydrobiopterin + anthranilate + O(2) = 3-hydroxyanthranilate + 7,8-dihydrobiopterin + H(2)O." [EC:1.14.16.3, RHEA:21171]
synonym: "anthranilate 3-hydroxylase activity" EXACT []
synonym: "anthranilate,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.16.3]
synonym: "anthranilic acid hydroxylase activity" BROAD [EC:1.14.16.3]
synonym: "anthranilic hydroxylase activity" BROAD [EC:1.14.16.3]
xref: EC:1.14.16.3
xref: KEGG:R01816
xref: MetaCyc:1.14.16.3-RXN
xref: RHEA:21171
is_a: GO:0016714 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050479
name: glyceryl-ether monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-alkyl-sn-glycerol + O2 + (tetrahydrobiopterin/tetrahydropteridine) = 1-hydroxyalkyl-sn-glycerol + H2O + (dihydrobiopterin/dihydropteridine)." [EC:1.14.16.5, MetaCyc:GLYCERYL-ETHER-MONOOXYGENASE-RXN]
synonym: "1-alkyl-sn-glycerol,tetrahydrobiopterin:oxygen oxidoreductase activity" EXACT [EC:1.14.16.5]
synonym: "alkylglycerol monooxygenase activity" EXACT [EC:1.14.16.5]
synonym: "glyceryl ether oxygenase activity" EXACT [EC:1.14.16.5]
synonym: "glyceryl etherase activity" EXACT [EC:1.14.16.5]
synonym: "glyceryl-ether cleaving enzyme activity" EXACT [EC:1.14.16.5]
synonym: "O-alkylglycerol monooxygenase activity" EXACT [EC:1.14.16.5]
xref: EC:1.14.16.5
xref: MetaCyc:GLYCERYL-ETHER-MONOOXYGENASE-RXN
is_a: GO:0016714 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050480
name: imidazolonepropionase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-3-(4-oxo-4,5-dihydro-1H-imidazol-5-yl)propanoic acid + H(2)O = N-formimidoyl-L-glutamate + H(+)." [EC:3.5.2.7, RHEA:23663]
subset: gosubset_prok
synonym: "3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate amidohydrolase activity" EXACT [EC:3.5.2.7]
synonym: "4(5)-imidazolone-5(4)-propionic acid hydrolase activity" EXACT [EC:3.5.2.7]
synonym: "imidazolone propionic acid hydrolase activity" EXACT [EC:3.5.2.7]
synonym: "imidazolone-5-propionate hydrolase activity" EXACT [EC:3.5.2.7]
xref: EC:3.5.2.7
xref: KEGG:R02288
xref: MetaCyc:IMIDAZOLONEPROPIONASE-RXN
xref: RHEA:23663
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0050481
name: mandelate 4-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-mandelate + 5,6,7,8-tetrahydrobiopterin + O(2) = (S)-4-hydroxymandelate + 7,8-dihydrobiopterin + H(2)O. (S)-2-hydroxy-2-phenylacetate is also known as S-mandelate." [EC:1.14.16.6, RHEA:21719]
synonym: "(S)-2-hydroxy-2-phenylacetate,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)" EXACT [EC:1.14.16.6]
synonym: "L-mandelate 4-hydroxylase activity" EXACT []
synonym: "mandelic acid 4-hydroxylase activity" EXACT [EC:1.14.16.6]
xref: EC:1.14.16.6
xref: KEGG:R03794
xref: MetaCyc:MANDELATE-4-MONOOXYGENASE-RXN
xref: RHEA:21719
is_a: GO:0016714 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050482
name: arachidonic acid secretion
namespace: biological_process
def: "The controlled release of arachidonic acid from a cell or a tissue." [GOC:ai]
comment: This term should be used to annotate release of arachidonic acid from the cell. For the hydrolytic release of arachidonic acid from a phospholipid, consider instead annotating to 'phospholipase A2 activity ; GO:0004623'.
is_a: GO:0032309 ! icosanoid secretion
is_a: GO:1903963 ! arachidonate transport

[Term]
id: GO:0050483
name: IMP 5'-nucleotidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5'-IMP + H2O = inosine + phosphate." [GOC:ai]
synonym: "IMP 5' nucleotidase activity" EXACT []
synonym: "IMP-GMP specific 5'-nucleotidase activity" RELATED []
xref: MetaCyc:RXN-7607
xref: Reactome:REACT_115780 "inosine 5'-monophosphate (IMP) + H2O => inosine + orthophosphate, Gallus gallus"
is_a: GO:0008253 ! 5'-nucleotidase activity

[Term]
id: GO:0050484
name: GMP 5'-nucleotidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5'-GMP + H2O = guanosine + phosphate." [GOC:ai]
synonym: "GMP 5' nucleotidase activity" EXACT []
synonym: "IMP-GMP specific 5'-nucleotidase activity" RELATED []
xref: MetaCyc:RXN-7609
is_a: GO:0008253 ! 5'-nucleotidase activity

[Term]
id: GO:0050485
name: oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y and the acceptor is disulfide." [GOC:ai]
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulphide as acceptor" EXACT []
xref: EC:1.21.4
is_a: GO:0046992 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond

[Term]
id: GO:0050486
name: intramolecular transferase activity, transferring hydroxy groups
namespace: molecular_function
def: "Catalysis of the transfer of a hydroxyl group from one position to another within a single molecule." [GOC:mah]
subset: gosubset_prok
xref: EC:5.4.4
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0050487
name: sulfoacetaldehyde acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl phosphate + sulfite = phosphate + sulfoacetaldehyde." [EC:2.3.3.15, RHEA:24207]
comment: Note that the enzyme sulfoacetaldehyde acetyltransferase also has sulfoacetaldehyde lyase activity (GO:0050312).
subset: gosubset_prok
synonym: "acetyl-phosphate:sulfite S-acetyltransferase (acyl-phosphate hydrolysing, 2-oxoethyl-forming)" EXACT [EC:2.3.3.15]
synonym: "sulphoacetaldehyde acetyltransferase activity" EXACT []
xref: EC:2.3.3.15
xref: KEGG:R05651
xref: MetaCyc:RXN-2364
xref: RHEA:24207
is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

[Term]
id: GO:0050488
name: ecdysteroid UDP-glucosyltransferase activity
namespace: molecular_function
alt_id: GO:0050489
def: "Catalysis of the reaction: UDP-glucose + ecdysteroid = UDP + glucosyl-ecdysteroid." [GOC:ai, PMID:10073711]
synonym: "ecdysteroid UDP-glucosyl/UDP-glucuronosyl transferase activity" RELATED []
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0050490
name: 1,4-lactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + a 1,4-lactone = a 4-hydroxyacid." [EC:3.1.1.25, MetaCyc:14-LACTONASE-RXN]
synonym: "1,4-lactone hydroxyacylhydrolase activity" EXACT [EC:3.1.1.25]
synonym: "gamma-lactonase activity" EXACT [EC:3.1.1.25]
xref: EC:3.1.1.25
xref: MetaCyc:14-LACTONASE-RXN
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0050491
name: sulcatone reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(+) + sulcatol = H(+) + NADH + sulcatone." [EC:1.1.1.260, RHEA:24487]
synonym: "sulcatol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.260]
xref: EC:1.1.1.260
xref: KEGG:R05678
xref: MetaCyc:1.1.1.260-RXN
xref: RHEA:24487
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050492
name: glycerol-1-phosphate dehydrogenase [NAD(P)+] activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(P)+ + sn-glycerol-1-phosphate = NAD(P)H + H+ + dihydroxy-acetone-phosphate." [EC:1.1.1.261, MetaCyc:1.1.1.261-RXN]
subset: gosubset_prok
synonym: "sn-glycerol-1-phosphate:NAD(P)+ 2-oxidoreductase activity" EXACT [EC:1.1.1.261]
xref: EC:1.1.1.261
xref: MetaCyc:1.1.1.261-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050493
name: GPI anchor biosynthetic process via N-threonyl-glycosylphosphatidylinositolethanolamine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-threonyl ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a threonyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0164]
subset: gosubset_prok
synonym: "GPI anchor anabolism via N-threonyl-glycosylphosphatidylinositolethanolamine" EXACT []
synonym: "GPI anchor formation via N-threonyl-glycosylphosphatidylinositolethanolamine" EXACT []
synonym: "GPI anchor synthesis via N-threonyl-glycosylphosphatidylinositolethanolamine" EXACT []
xref: RESID:AA0164
is_a: GO:0006506 ! GPI anchor biosynthetic process
is_a: GO:0018210 ! peptidyl-threonine modification

[Term]
id: GO:0050494
name: GSI anchor biosynthetic process via N-glycyl-glycosylsphingolipidinositolethanolamine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-glycine ethanolamide-linked glycosylsphingolipidinositol (GSI) anchor following hydrolysis of a glycyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0165]
subset: gosubset_prok
synonym: "GSI anchor anabolism via N-glycyl-glycosylsphingolipidinositolethanolamine" EXACT []
synonym: "GSI anchor formation via N-glycyl-glycosylsphingolipidinositolethanolamine" EXACT []
synonym: "GSI anchor synthesis via N-glycyl-glycosylsphingolipidinositolethanolamine" EXACT []
xref: RESID:AA0165
is_a: GO:0018201 ! peptidyl-glycine modification
is_a: GO:0042082 ! GSI anchor biosynthetic process

[Term]
id: GO:0050495
name: peptidyl-glycyl-phosphatidylethanolamine biosynthetic process from peptidyl-glycine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-glycine ethanolamide-linked phosphatide following hydrolysis of a glycyl-peptide bond, as in the cleavage of arginine from the carboxy-terminal of Apg8 followed by its amidation with phosphatidylethanolamine." [RESID:AA0346]
subset: gosubset_prok
synonym: "peptidyl-glycyl-phosphatidylethanolamine anabolism from peptidyl-glycine" EXACT []
synonym: "peptidyl-glycyl-phosphatidylethanolamine formation from peptidyl-glycine" EXACT []
synonym: "peptidyl-glycyl-phosphatidylethanolamine synthesis from peptidyl-glycine" EXACT []
xref: RESID:AA0346
is_a: GO:0018201 ! peptidyl-glycine modification

[Term]
id: GO:0050496
name: peptidyl-L-glutamyl 5-omega-hydroxyceramide ester biosynthetic process from peptidyl-glutamine
namespace: biological_process
def: "The modification of peptidyl-glutamine residues by deamidation and esterification with omega-hydroxyceramide." [PMID:10411887, RESID:AA0347]
subset: gosubset_prok
synonym: "peptidyl-L-glutamyl 5-omega-hydroxyceramide ester anabolism from peptidyl-glutamine" EXACT []
synonym: "peptidyl-L-glutamyl 5-omega-hydroxyceramide ester formation from peptidyl-glutamine" EXACT []
synonym: "peptidyl-L-glutamyl 5-omega-hydroxyceramide ester synthesis from peptidyl-glutamine" EXACT []
xref: RESID:AA0340
is_a: GO:0018199 ! peptidyl-glutamine modification

[Term]
id: GO:0050497
name: transferase activity, transferring alkylthio groups
namespace: molecular_function
def: "Catalysis of the transfer of an alkylthio group from one compound (donor) to another (acceptor)." [GOC:ai]
subset: gosubset_prok
xref: EC:2.8.4
is_a: GO:0016782 ! transferase activity, transferring sulfur-containing groups

[Term]
id: GO:0050498
name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with 2-oxoglutarate as one donor, and the other dehydrogenated
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and the latter donor is dehydrogenated." [GOC:mah]
subset: gosubset_prok
xref: EC:1.14.20
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0050499
name: oxidoreductase activity, acting on phosphorus or arsenic in donors, with NAD(P)+ as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a NAD(P)+ to NAD(P)H." [GOC:mah]
subset: gosubset_prok
xref: EC:1.20.1
is_a: GO:0030613 ! oxidoreductase activity, acting on phosphorus or arsenic in donors

[Term]
id: GO:0050500
name: 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphate + beta-D-galactopyranosyl-(1->3)-N-acetyl-D-glucosamine = N-acetyl-D-glucosamine + alpha-D-galactopyranose 1-phosphate." [EC:2.4.1.211, MetaCyc:2.4.1.211-RXN]
synonym: "beta-1,3-galactosyl-N-acetylhexosamine phosphorylase activity" EXACT []
synonym: "beta-D-galactopyranosyl-(1,3)-N-acetyl-D-hexosamine:phosphate galactosyltransferase activity" EXACT [EC:2.4.1.211]
synonym: "beta-D-galactopyranosyl-(1->3)-N-acetyl-D-hexosamine:phosphate galactosyltransferase activity" EXACT [EC:2.4.1.211]
xref: EC:2.4.1.211
xref: MetaCyc:2.4.1.211-RXN
xref: RHEA:20288
is_a: GO:0004645 ! phosphorylase activity

[Term]
id: GO:0050501
name: hyaluronan synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-D-glucuronate + UDP-N-acetyl-D-glucosamine = [beta-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)](n) + 2n UDP." [EC:2.4.1.212, MetaCyc:2.4.1.212-RXN]
subset: gosubset_prok
synonym: "alternating UDP-alpha-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1,3)-[nascent hyaluronan] 4-N-acetyl-beta-D-glucosaminyltransferase and UDP-alpha-D-glucuronate:N-acetyl-beta-D-glucosaminyl-(1,4)-[nascent hyaluronan] 3-beta-D-glucuronosyltransferase activity" EXACT [EC:2.4.1.212]
synonym: "alternating UDP-alpha-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->3)-[nascent hyaluronan] 4-N-acetyl-beta-D-glucosaminyltransferase and UDP-alpha-D-glucuronate:N-acetyl-beta-D-glucosaminyl-(1->4)-[nascent hyaluronan] 3-beta-D-glucuronosyltransferase activity" EXACT [EC:2.4.1.212]
synonym: "HAS activity" BROAD [EC:2.4.1.212]
synonym: "seHAS" RELATED [EC:2.4.1.212]
synonym: "spHAS" RELATED [EC:2.4.1.212]
xref: EC:2.4.1.212
xref: MetaCyc:2.4.1.212-RXN
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0050502
name: cis-zeatin O-beta-D-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-zeatin + UDP-D-glucose = O-beta-D-glucosyl-cis-zeatin + H(+) + UDP." [EC:2.4.1.215, RHEA:20684]
synonym: "cis-zeatin O-b-D-glucosyltransferase activity" EXACT []
synonym: "UDP-glucose:cis-zeatin O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.215]
synonym: "UDPglucose:cis-zeatin O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.215]
xref: EC:2.4.1.215
xref: KEGG:R07260
xref: MetaCyc:RXN-4735
xref: RHEA:20684
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0050503
name: trehalose 6-phosphate phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: trehalose 6-phosphate + phosphate = glucose 6-phosphate + beta-D-glucose 1-phosphate." [EC:2.4.1.216, MetaCyc:2.4.1.216-RXN]
subset: gosubset_prok
synonym: "trehalose 6-phosphate:phosphate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.216]
xref: EC:2.4.1.216
xref: MetaCyc:2.4.1.216-RXN
xref: RHEA:20867
is_a: GO:0004645 ! phosphorylase activity

[Term]
id: GO:0050504
name: mannosyl-3-phosphoglycerate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-phospho-D-glycerate + GDP-alpha-D-mannose = 2-(alpha-D-mannosyl)-3-phosphoglycerate + GDP + H(+)." [EC:2.4.1.217, RHEA:13540]
subset: gosubset_prok
synonym: "GDP-mannose:3-phosphoglycerate 3-alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.217]
synonym: "MPG synthase activity" EXACT [EC:2.4.1.217]
xref: EC:2.4.1.217
xref: KEGG:R05768
xref: MetaCyc:2.4.1.217-RXN
xref: RHEA:13540
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0050505
name: hydroquinone glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydroquinone + UDP-D-glucose = H(+) + hydroquinone O-beta-D-glucopyranoside + UDP." [EC:2.4.1.218, RHEA:12563]
synonym: "arbutin synthase activity" EXACT [EC:2.4.1.218]
synonym: "hydroquinone:O-glucosyltransferase activity" EXACT [EC:2.4.1.218]
synonym: "UDP-glucose:hydroquinone-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.218]
synonym: "UDPglucose:hydroquinone-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.218]
xref: EC:2.4.1.218
xref: KEGG:R05769
xref: MetaCyc:2.4.1.218-RXN
xref: RHEA:12563
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0050506
name: vomilenine glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-D-glucose + vomilenine = H(+) + raucaffricine + UDP." [EC:2.4.1.219, RHEA:19388]
synonym: "UDP-glucose:vomilenine 21-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.219]
synonym: "UDPG:vomilenine 21-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.219]
synonym: "UDPG:vomilenine 21beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.219]
synonym: "vomilenine-glucosyltransferase activity" EXACT [EC:2.4.1.219]
xref: EC:2.4.1.219
xref: KEGG:R05882
xref: MetaCyc:2.4.1.219-RXN
xref: RHEA:19388
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0050507
name: indoxyl-UDPG glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: indoxyl + UDP-D-glucose = H(+) + indican + UDP." [EC:2.4.1.220, RHEA:12007]
synonym: "indoxyl-UDPG-glucosyltransferase activity" EXACT [EC:2.4.1.220]
synonym: "UDP-glucose:indoxyl 3-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.220]
xref: EC:2.4.1.220
xref: KEGG:R06048
xref: MetaCyc:2.4.1.220-RXN
xref: RHEA:12007
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0050508
name: glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP-N-acetyl-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP." [EC:2.4.1.224, MetaCyc:2.4.1.224-RXN]
synonym: "alpha-N-acetylglucosaminyltransferase II activity" EXACT [EC:2.4.1.224]
synonym: "glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-a-N-acetylglucosaminyltransferase activity" EXACT []
synonym: "glucuronyl-N-acetylglucosaminylproteoglycan alpha-1,4-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.224]
synonym: "UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.224]
xref: EC:2.4.1.224
xref: MetaCyc:2.4.1.224-RXN
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0050509
name: N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP." [EC:2.4.1.225, MetaCyc:2.4.1.225-RXN]
synonym: "heparan glucuronyltransferase II activity" EXACT [EC:2.4.1.225]
synonym: "N-acetylglucosaminyl-proteoglycan 4-b-glucuronosyltransferase activity" EXACT []
synonym: "N-acetylglucosaminylproteoglycan beta-1,4-glucuronyltransferase activity" EXACT [EC:2.4.1.225]
synonym: "UDP-alpha-D-glucuronate:N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan 4-beta-glucuronosyltransferase activity" EXACT [EC:2.4.1.225]
xref: EC:2.4.1.225
xref: MetaCyc:2.4.1.225-RXN
is_a: GO:0015020 ! glucuronosyltransferase activity

[Term]
id: GO:0050510
name: N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,3)-N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP." [EC:2.4.1.226, MetaCyc:2.4.1.226-RXN]
synonym: "alpha-D-glucuronate:N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan 3-beta-glucuronosyltransferase activity" EXACT [EC:2.4.1.226]
synonym: "chondroitin glucuronyltransferase II activity" EXACT [EC:2.4.1.226]
synonym: "N-acetylgalactosaminyl-proteoglycan 3-b-glucuronosyltransferase activity" EXACT []
xref: EC:2.4.1.226
xref: MetaCyc:2.4.1.226-RXN
is_a: GO:0015020 ! glucuronosyltransferase activity

[Term]
id: GO:0050511
name: undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol + UDP-N-acetyl-D-glucosamine = GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol + UDP." [EC:2.4.1.227, MetaCyc:2.4.1.227-RXN]
comment: Note that EC classifies 'UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity ; GO:0051991' and 'undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity ; GO:0050511' under the same EC number, EC:2.4.1.227.
subset: gosubset_prok
synonym: "MurG transferase activity" RELATED [EC:2.4.1.227]
synonym: "UDP-N-acetyl-D-glucosamine:N-acetyl-alpha-D-muramyl(oyl-L-Ala- gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol beta-1,4-N-acetylglucosaminlytransferase activity" EXACT [EC:2.4.1.227]
synonym: "UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase activity" EXACT [EC:2.4.1.227]
synonym: "undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase activity" EXACT [EC:2.4.1.227]
synonym: "undecaprenyldiphospho-muramoylpentapeptide b-N-acetylglucosaminyltransferase activity" EXACT []
xref: EC:2.4.1.227
xref: MetaCyc:RXN-8976
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0050512
name: lactosylceramide 4-alpha-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-D-galactosyl-(1,4)-D-glucosylceramide + UDP-galactose = alpha-D-galactosyl-(1,4)-beta-D-galactosyl-(1,4)-D-glucosylceramide + UDP." [EC:2.4.1.228, MetaCyc:2.4.1.228-RXN]
synonym: "Gal-beta-(1,4)-Glc-beta-1-Cer alpha-(1,4)-galactosyltransferase activity" EXACT [EC:2.4.1.228]
synonym: "Gal-beta-1,4-Glc-beta-1-Cer alpha-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.228]
synonym: "globotriaosylceramide/CD77 synthase activity" NARROW [EC:2.4.1.228]
synonym: "histo-blood group P(k) UDP-galactose activity" NARROW [EC:2.4.1.228]
synonym: "histo-blood group Pk UDP-galactose" RELATED [EC:2.4.1.228]
synonym: "lactosylceramide 4-a-galactosyltransferase activity" EXACT []
synonym: "UDP-galactose:lactosylceramide 4II-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.228]
xref: EC:2.4.1.228
xref: MetaCyc:2.4.1.228-RXN
xref: RHEA:11927
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0050513
name: glycoprotein 2-beta-D-xylosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + UDP-alpha-D-xylose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-[beta-D-xylosyl-(1->2)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + H(+) + UDP." [EC:2.4.2.38, RHEA:10615]
synonym: "1,2-beta-xylosyltransferase activity" EXACT [EC:2.4.2.38]
synonym: "beta-1,2-xylosyltransferase activity" EXACT [EC:2.4.2.38]
synonym: "glycoprotein 2-b-D-xylosyltransferase activity" EXACT []
xref: EC:2.4.2.38
xref: KEGG:R06016
xref: MetaCyc:2.4.2.38-RXN
xref: RHEA:10615
is_a: GO:0035252 ! UDP-xylosyltransferase activity

[Term]
id: GO:0050514
name: homospermidine synthase (spermidine-specific) activity
namespace: molecular_function
def: "Catalysis of the reaction: spermidine + putrescine = sym-homospermidine + propane-1,3-diamine." [EC:2.5.1.45, MetaCyc:2.5.1.45-RXN]
synonym: "spermidine:putrescine 4-aminobutyltransferase (propane-1,3-diamine-forming)" EXACT [EC:2.5.1.45]
xref: EC:2.5.1.45
xref: MetaCyc:2.5.1.45-RXN
xref: RHEA:11239
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0050515
name: 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity
namespace: molecular_function
alt_id: GO:0008698
def: "Catalysis of the reaction: 4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + 2 H(+)." [EC:2.7.1.148, RHEA:18440]
subset: gosubset_prok
synonym: "4-diphosphocytidyl-2-C-methyl-D-erythritol kinase activity" EXACT [EC:2.7.1.148]
synonym: "4-diphosphocytidyl-2C-methyl-D-erythritol kinase activity" EXACT []
synonym: "ATP:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol 2-phosphotransferase activity" EXACT [EC:2.7.1.148]
synonym: "CDP-ME kinase activity" EXACT [EC:2.7.1.148]
synonym: "CMK activity" RELATED [EC:2.7.1.148]
xref: EC:2.7.1.148
xref: KEGG:R05634
xref: MetaCyc:2.7.1.148-RXN
xref: RHEA:18440
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0050516
name: obsolete inositol polyphosphate multikinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reactions: ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate, and ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate." [EC:2.7.1.151, MetaCyc:2.7.1.151-RXN]
comment: This term was made obsolete because this activity is currently defined as catalyzing two sequential reactions based on a gene product. However, "inositol polyphosphate multikinase activity" in some organisms can catalyze additional reactions. In addition, the reactions listed in the definition can be catalyzed independently by other gene products.
synonym: "ArgRIII" RELATED [EC:2.7.1.151]
synonym: "AtIpk2-alpha activity" NARROW [EC:2.7.1.151]
synonym: "AtIpk2-beta activity" NARROW [EC:2.7.1.151]
synonym: "AtIpk2alpha" RELATED [EC:2.7.1.151]
synonym: "AtIpk2beta" RELATED [EC:2.7.1.151]
synonym: "ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase activity" EXACT [EC:2.7.1.151]
synonym: "inositol polyphosphate 6-/3-/5-kinase activity" EXACT [EC:2.7.1.151]
synonym: "inositol polyphosphate multikinase activity" EXACT []
synonym: "inositol-polyphosphate multikinase activity" EXACT []
synonym: "IP3/IP4 6-/3-kinase activity" EXACT [EC:2.7.1.151]
synonym: "IP3/IP4 dual-specificity 6-/3-kinase activity" EXACT [EC:2.7.1.151]
synonym: "IpK2 activity" RELATED [EC:2.7.1.151]
synonym: "IpmK" RELATED [EC:2.7.1.151]
xref: EC:2.7.1.151
xref: MetaCyc:2.7.1.151-RXN
is_obsolete: true

[Term]
id: GO:0050517
name: obsolete inositol hexakisphosphate kinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reactions: ATP + 1D-myo-inositol hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate, and ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate (isomeric configuration unknown)." [EC:2.7.4.21, MetaCyc:2.7.4.21-RXN]
comment: Note that this was EC:2.7.1.152. This term was made obsolete because this activity is currently defined as catalyzing two reactions based on a gene product. The reactions listed in the definition can be catalyzed independently by other gene products.
synonym: "ATP:1D-myo-inositol-hexakisphosphate 5-phosphotransferase activity" EXACT [EC:2.7.4.21]
synonym: "ATP:1D-myo-inositol-hexakisphosphate phosphotransferase activity" EXACT [EC:2.7.4.21]
synonym: "inositol hexakisphosphate kinase activity" EXACT []
synonym: "inositol-hexakisphosphate kinase activity" EXACT []
xref: EC:2.7.4.21
xref: MetaCyc:2.7.1.152-RXN
is_obsolete: true

[Term]
id: GO:0050518
name: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
namespace: molecular_function
alt_id: GO:0008699
def: "Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + CTP = 4-CDP-2-C-methyl-D-erythritol + diphosphate." [EC:2.7.7.60, RHEA:13432]
subset: gosubset_prok
synonym: "4-diphosphocytidyl-2-C-methyl-D-erythritol synthase activity" EXACT [EC:2.7.7.60]
synonym: "4-diphosphocytidyl-2C-methyl-D-erythritol synthase activity" EXACT []
synonym: "CTP:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity" EXACT []
synonym: "MCT activity" RELATED [EC:2.7.7.60]
synonym: "MEP cytidylyltransferase activity" EXACT []
xref: EC:2.7.7.60
xref: KEGG:R05633
xref: MetaCyc:2.7.7.60-RXN
xref: RHEA:13432
is_a: GO:0070567 ! cytidylyltransferase activity

[Term]
id: GO:0050519
name: holo-citrate lyase synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: apo-citrate lyase + 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA = diphosphate + holo-citrate lyase." [EC:2.7.7.61, MetaCyc:2.7.7.61-RXN]
subset: gosubset_prok
synonym: "2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase activity" EXACT [EC:2.7.7.61]
synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase activity" EXACT [EC:2.7.7.61]
synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase adenylyltransferase activity" EXACT [EC:2.7.7.61]
synonym: "CitX" RELATED [EC:2.7.7.61]
synonym: "holo-ACP synthase activity" RELATED [EC:2.7.7.61]
xref: EC:2.7.7.61
xref: MetaCyc:2.7.7.61-RXN
is_a: GO:0016779 ! nucleotidyltransferase activity

[Term]
id: GO:0050520
name: phosphatidylcholine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: CDP-diacylglycerol + choline = 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)." [EC:2.7.8.24, RHEA:14600]
subset: gosubset_prok
synonym: "CDP-diacylglycerol:choline O-phosphatidyltransferase activity" EXACT [EC:2.7.8.24]
synonym: "CDP-diglyceride-choline O-phosphatidyltransferase activity" EXACT [EC:2.7.8.24]
synonym: "CDPdiglyceride-choline O-phosphatidyltransferase activity" EXACT [EC:2.7.8.24]
synonym: "PC synthase activity" EXACT [EC:2.7.8.24]
xref: EC:2.7.8.24
xref: KEGG:R05794
xref: MetaCyc:2.7.8.24-RXN
xref: RHEA:14600
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0050521
name: alpha-glucan, water dikinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + alpha-glucan + H2O = AMP + phospho-alpha-glucan + phosphate." [EC:2.7.9.4, MetaCyc:2.7.9.4-RXN]
synonym: "a-glucan, water dikinase activity" EXACT []
synonym: "alpha-glucan,water dikinase activity" EXACT [EC:2.7.9.4]
synonym: "ATP:alpha-glucan, water phosphotransferase activity" EXACT [EC:2.7.9.4]
synonym: "GWD" RELATED [EC:2.7.9.4]
synonym: "starch-related R1 protein activity" EXACT [EC:2.7.9.4]
xref: EC:2.7.9.4
xref: MetaCyc:2.7.9.4-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016781 ! phosphotransferase activity, paired acceptors

[Term]
id: GO:0050522
name: oxidoreductase activity, acting on phosphorus or arsenic in donors, with other known acceptors
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which phosphorus or arsenic acts as a hydrogen or electron donor and reduces a known acceptor other than disulfide, NAD or NADP." [GOC:ai]
subset: gosubset_prok
xref: EC:1.20.98
is_a: GO:0030613 ! oxidoreductase activity, acting on phosphorus or arsenic in donors

[Term]
id: GO:0050523
name: obsolete oxidoreductase activity, acting on phosphorus or arsenic in donors, with other acceptors
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which phosphorus or arsenic acts as a hydrogen or electron donor and reduces an acceptor other than disulfide, NAD or NADP." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "oxidoreductase activity, acting on phosphorus or arsenic in donors, with other acceptors" EXACT []
is_obsolete: true
consider: GO:0030613

[Term]
id: GO:0050524
name: coenzyme-B sulfoethylthiotransferase activity
namespace: molecular_function
alt_id: GO:0018552
def: "Catalysis of the reaction: coenzyme B + methyl-coenzyme M = coenzyme M-coenzyme B heterodisulfide + methane. Methyl-CoM is also known as 2-(methylthio)ethanesulfonate, coenzyme B as N-(7-mercaptoheptanoyl)threonine 3-O-phosphate, and coenzyme M-coenzyme B heterodisulfide as CoM-S-S-CoB." [EC:2.8.4.1, RHEA:12535]
subset: gosubset_prok
synonym: "2-(methylthio)ethanesulfonate:N-(7-thioheptanoyl)-3-O-phosphothreonine S-(2-sulfoethyl)thiotransferase activity" EXACT [EC:2.8.4.1]
synonym: "coenzyme-B sulphoethylthiotransferase activity" EXACT []
synonym: "methyl coenzyme M reductase activity" EXACT [EC:2.8.4.1]
synonym: "methyl-coenzyme-M reductase activity" EXACT []
synonym: "methyl-CoM reductase activity" EXACT [EC:2.8.4.1]
xref: EC:2.8.4.1
xref: KEGG:R04541
xref: MetaCyc:METHYL-COM-HTP-RXN
xref: RHEA:12535
xref: UM-BBD_reactionID:r0356
is_a: GO:0050497 ! transferase activity, transferring alkylthio groups

[Term]
id: GO:0050525
name: cutinase activity
namespace: molecular_function
def: "Catalysis of the reaction: cutin + H2O = cutin monomers." [EC:3.1.1.74, MetaCyc:3.1.1.74-RXN]
subset: gosubset_prok
synonym: "cutin hydrolase activity" EXACT [EC:3.1.1.74]
xref: EC:3.1.1.74
xref: MetaCyc:3.1.1.74-RXN
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0050526
name: poly(3-hydroxybutyrate) depolymerase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + poly[(R)-3-hydroxybutanoate](n) = poly[(R)-3-hydroxybutanoate](x) + poly[(R)-3-hydroxybutanoate](n-x); x is 1-5." [EC:3.1.1.75, MetaCyc:3.1.1.75-RXN]
subset: gosubset_prok
synonym: "PHB depolymerase activity" EXACT [EC:3.1.1.75]
synonym: "poly((R)-hydroxyalkanoic acid) depolymerase activity" BROAD [EC:3.1.1.75]
synonym: "poly(3HB) depolymerase activity" EXACT [EC:3.1.1.75]
synonym: "poly(HA(SCL)) depolymerase activity" EXACT [EC:3.1.1.75]
synonym: "poly(HA) depolymerase activity" RELATED [EC:3.1.1.75]
synonym: "poly(HASCL) depolymerase activity" EXACT [EC:3.1.1.75]
synonym: "poly[(R)-3-hydroxybutyrate] hydrolase activity" EXACT [EC:3.1.1.75]
synonym: "poly[(R)-hydroxyalkanoic acid] depolymerase" BROAD [EC:3.1.1.75]
xref: EC:3.1.1.75
xref: MetaCyc:3.1.1.75-RXN
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0050527
name: poly(3-hydroxyoctanoate) depolymerase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + poly[(R)-3-hydroxyoctanoate](n) = poly[(R)-3-hydroxyoctanoate](x) + poly[(R)-3-hydroxyoctanoate](n-x); x is 1-5." [EC:3.1.1.76, MetaCyc:3.1.1.76-RXN]
subset: gosubset_prok
synonym: "PHA depolymerase activity" BROAD [EC:3.1.1.76]
synonym: "PHO depolymerase activity" EXACT [EC:3.1.1.76]
synonym: "poly((R)-3-hydroxyoctanoate) hydrolase activity" EXACT [EC:3.1.1.76]
synonym: "poly((R)-hydroxyalkanoic acid) depolymerase activity" BROAD [EC:3.1.1.76]
synonym: "poly(3HO) depolymerase activity" EXACT [EC:3.1.1.76]
synonym: "poly(HA(MCL)) depolymerase activity" EXACT [EC:3.1.1.76]
synonym: "poly(HA) depolymerase activity" BROAD [EC:3.1.1.76]
synonym: "poly(HAMCL) depolymerase activity" EXACT [EC:3.1.1.76]
synonym: "poly[(R)-3-hydroxyoctanoate] hydrolase activity" EXACT [EC:3.1.1.76]
synonym: "poly[(R)-hydroxyalkanoic acid] depolymerase" BROAD [EC:3.1.1.76]
synonym: "poly{oxycarbonyl[(R)-2-pentylethylene]} hydrolase activity" EXACT [EC:3.1.1.76]
xref: EC:3.1.1.76
xref: MetaCyc:3.1.1.76-RXN
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0050528
name: acyloxyacyl hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-(acyloxy)acyl group of bacterial toxin = 3-hydroxyacyl group of bacterial toxin + a fatty acid." [EC:3.1.1.77, MetaCyc:3.1.1.77-RXN]
xref: EC:3.1.1.77
xref: MetaCyc:3.1.1.77-RXN
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0050529
name: polyneuridine-aldehyde esterase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + polyneuridine aldehyde = 16-epivellosimine + CO(2) + methanol." [EC:3.1.1.78, RHEA:17504]
synonym: "PNAE activity" EXACT [EC:3.1.1.78]
synonym: "polyneuridine aldehyde esterase activity" EXACT [EC:3.1.1.78]
synonym: "polyneuridine aldehyde hydrolase (decarboxylating)" EXACT [EC:3.1.1.78]
xref: EC:3.1.1.78
xref: KEGG:R05825
xref: MetaCyc:3.1.1.78-RXN
xref: RHEA:17504
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0050530
name: glucosylglycerol 3-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-O-(beta-D-glucosyl)-sn-glycerol 3-phosphate + H(2)O = 2-O-(beta-D-glucosyl)-sn-glycerol + phosphate." [EC:3.1.3.69, RHEA:22655]
subset: gosubset_prok
synonym: "2-(beta-D-glucosyl)-sn-glycerol-3-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.69]
synonym: "salt tolerance protein A" RELATED [EC:3.1.3.69]
synonym: "StpA" RELATED [EC:3.1.3.69]
xref: EC:3.1.3.69
xref: KEGG:R05791
xref: MetaCyc:3.1.3.69-RXN
xref: RHEA:22655
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0050531
name: mannosyl-3-phosphoglycerate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-(alpha-D-mannosyl)-3-phosphoglycerate + H(2)O = 2-(alpha-D-mannosyl)-D-glycerate + phosphate." [EC:3.1.3.70, RHEA:19312]
subset: gosubset_prok
synonym: "alpha-D-mannosyl-3-phosphoglycerate phosphohydrolase activity" EXACT [EC:3.1.3.70]
xref: EC:3.1.3.70
xref: KEGG:R05790
xref: MetaCyc:3.1.3.70-RXN
xref: RHEA:19312
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0050532
name: 2-phosphosulfolactate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2R)-O-phospho-3-sulfolactate + H(2)O = (R)-3-sulfolactate + phosphate." [EC:3.1.3.71, RHEA:23419]
subset: gosubset_prok
synonym: "(2R)-phosphosulfolactate phosphohydrolase activity" EXACT [EC:3.1.3.71]
synonym: "(R)-2-phospho-3-sulfolactate phosphohydrolase activity" EXACT [EC:3.1.3.71]
synonym: "2-phosphosulpholactate phosphatase activity" EXACT []
synonym: "ComB phosphatase activity" RELATED [EC:3.1.3.71]
xref: EC:3.1.3.71
xref: KEGG:R05789
xref: MetaCyc:R229-RXN
xref: RHEA:23419
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0050533
name: 5-phytase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + myo-inositol hexakisphosphate = phosphate + 1L-myo-inositol 1,2,3,4,6-pentakisphosphate." [EC:3.1.3.72, MetaCyc:3.1.3.72-RXN]
synonym: "myo-inositol-hexakisphosphate 5-phosphohydrolase activity" EXACT [EC:3.1.3.72]
xref: EC:3.1.3.72
xref: MetaCyc:3.1.3.72-RXN
xref: RHEA:13004
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0050534
name: 3-deoxyoctulosonase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-deoxyoctulosonyl-lipopolysaccharide + H2O = 3-deoxyoctulosonic acid + lipopolysaccharide." [EC:3.2.1.144, MetaCyc:3.2.1.144-RXN]
synonym: "3-deoxyoctulosonyl-lipopolysaccharide hydrolase activity" EXACT [EC:3.2.1.144]
synonym: "alpha-Kdo-ase activity" EXACT [EC:3.2.1.144]
xref: EC:3.2.1.144
xref: MetaCyc:3.2.1.144-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0050535
name: beta-primeverosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside + H2O = 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose + an alcohol." [EC:3.2.1.149, MetaCyc:3.2.1.149-RXN]
synonym: "6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside 6-O-(beta-D-xylosyl)-beta-D-glucohydrolase activity" EXACT [EC:3.2.1.149]
synonym: "b-primeverosidase activity" EXACT []
xref: EC:3.2.1.149
xref: MetaCyc:3.2.1.149-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0050536
name: (S)-N-acetyl-1-phenylethylamine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetylphenylethylamine + H(2)O = acetate + phenylethylamine." [EC:3.5.1.85, RHEA:23955]
synonym: "(S)-N-acetyl-1-phenylethylamine amidohydrolase activity" EXACT [EC:3.5.1.85]
synonym: "(S)-N-acetylphenylethylamine:H2O hydrolase activity" EXACT [EC:3.5.1.85]
xref: EC:3.5.1.85
xref: KEGG:R07301
xref: MetaCyc:3.5.1.85-RXN
xref: RHEA:23955
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050537
name: mandelamide amidase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-mandelamide + H(2)O = (R)-mandelate + NH(4)(+)." [EC:3.5.1.86, RHEA:22879]
synonym: "mandelamide hydrolase activity" EXACT [EC:3.5.1.86]
synonym: "Pseudomonas mandelamide hydrolase activity" EXACT [EC:3.5.1.86]
xref: EC:3.5.1.86
xref: KEGG:R05783
xref: MetaCyc:3.5.1.86-RXN
xref: RHEA:22879
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050538
name: N-carbamoyl-L-amino-acid hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-carbamoyl-L-2-amino acid + H2O = L-2-amino acid + NH3 + CO2. The N-carbamoyl-L-2-amino acid is a 2-ureido carboxylate." [EC:3.5.1.87, MetaCyc:3.5.1.87-RXN]
subset: gosubset_prok
synonym: "L-carbamoylase activity" EXACT [EC:3.5.1.87]
synonym: "N-carbamoyl-L-amino acid amidohydrolase activity" EXACT [EC:3.5.1.87]
xref: EC:3.5.1.87
xref: MetaCyc:3.5.1.87-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050539
name: maleimide hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + maleimide = H(+) + maleamate." [EC:3.5.2.16, RHEA:24479]
synonym: "cyclic imide hydrolase activity" EXACT [EC:3.5.2.16]
synonym: "cyclic-imide amidohydrolase (decyclicizing)" EXACT [EC:3.5.2.16]
synonym: "cyclic-imide amidohydrolase (decyclizing)" EXACT [EC:3.5.2.16]
synonym: "imidase activity" BROAD [EC:3.5.2.16]
xref: EC:3.5.2.16
xref: KEGG:R05781
xref: MetaCyc:3.5.2.16-RXN
xref: RHEA:24479
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0050540
name: 2-aminomuconate deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-aminomuconate + H(2)O + H(+) = (Z)-5-oxohex-2-enedioate + NH(4)(+)." [EC:3.5.99.5, RHEA:20999]
subset: gosubset_prok
synonym: "2-aminomuconate aminohydrolase activity" EXACT [EC:3.5.99.5]
xref: EC:3.5.99.5
xref: KEGG:R03887
xref: MetaCyc:3.5.99.5-RXN
xref: RHEA:20999
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0050541
name: beta,beta-carotene-9',10'-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-carotene + O2 = beta-apo-10'-carotenal + beta-ionone." [PMID:11278918]
synonym: "b,b-carotene-9',10'-dioxygenase activity" EXACT []
is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor

[Term]
id: GO:0050542
name: icosanoid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with icosanoids, any C20 polyunsaturated fatty acids or their derivatives, including the leukotrienes and the prostanoids." [ISBN:0198506732]
synonym: "eicosanoid binding" EXACT []
is_a: GO:0031406 ! carboxylic acid binding
is_a: GO:1901567 ! fatty acid derivative binding

[Term]
id: GO:0050543
name: icosatetraenoic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with icosatetraenoic acid, any straight-chain fatty acid with twenty carbon atoms and four double bonds per molecule." [ISBN:0198506732]
synonym: "eicosatetraenoic acid binding" EXACT []
is_a: GO:0036041 ! long-chain fatty acid binding

[Term]
id: GO:0050544
name: arachidonic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer." [GOC:ai]
synonym: "arachidonate binding" EXACT []
is_a: GO:0050542 ! icosanoid binding
is_a: GO:0050543 ! icosatetraenoic acid binding

[Term]
id: GO:0050545
name: sulfopyruvate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-sulfopyruvate + H(+) = CO(2) + sulfoacetaldehyde." [EC:4.1.1.79, RHEA:20951]
subset: gosubset_prok
synonym: "sulfopyruvate carboxy-lyase (2-sulfoacetaldehyde-forming)" EXACT [EC:4.1.1.79]
synonym: "sulfopyruvate carboxy-lyase activity" EXACT [EC:4.1.1.79]
synonym: "sulphopyruvate decarboxylase activity" EXACT []
xref: EC:4.1.1.79
xref: KEGG:R05774
xref: MetaCyc:R231-RXN
xref: RHEA:20951
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050546
name: 4-hydroxyphenylpyruvate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: (4-hydroxyphenyl)pyruvate + H(+) = (4-hydroxyphenyl)acetaldehyde + CO(2)." [EC:4.1.1.80, RHEA:18700]
synonym: "4-hydroxyphenylpyruvate carboxy-lyase (4-hydroxyphenylacetaldehyde-forming)" EXACT [EC:4.1.1.80]
synonym: "4-hydroxyphenylpyruvate carboxy-lyase activity" EXACT [EC:4.1.1.80]
xref: EC:4.1.1.80
xref: KEGG:R03341
xref: MetaCyc:4.1.1.80-RXN
xref: RHEA:18700
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050547
name: vanillin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA = acetyl-CoA + vanillin." [EC:4.1.2.41, RHEA:18728]
synonym: "3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA vanillin-lyase (acetyl-CoA-forming)" EXACT [EC:4.1.2.41]
synonym: "3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propionyl-CoA:vanillin lyase (acetyl-CoA-forming)" EXACT [EC:4.1.2.41]
xref: EC:4.1.2.41
xref: KEGG:R05773
xref: MetaCyc:4.1.2.41-RXN
xref: RHEA:18728
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0050548
name: trans-feruloyl-CoA hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-feruloyl-CoA + H2O = 4-hydroxy-3-methoxyphenyl-beta-hydroxypropionyl-CoA." [EC:4.2.1.101, MetaCyc:4.2.1.101-RXN]
synonym: "4-hydroxy-3-methoxyphenyl-beta-hydroxypropanoyl-CoA hydro-lyase (trans-feruloyl-CoA-forming)" EXACT [EC:4.2.1.101]
synonym: "trans-feruloyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.101]
xref: EC:4.2.1.101
xref: MetaCyc:4.2.1.101-RXN
xref: RHEA:14520
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050549
name: cyclohexyl-isocyanide hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-cyclohexylformamide + H(+) = cyclohexyl isocyanide + H(2)O." [EC:4.2.1.103, RHEA:18200]
subset: gosubset_prok
synonym: "isonitrile hydratase activity" EXACT [EC:4.2.1.103]
synonym: "N-cyclohexylformamide hydro-lyase (cyclohexyl-isocyanide-forming)" EXACT [EC:4.2.1.103]
synonym: "N-cyclohexylformamide hydro-lyase activity" EXACT [EC:4.2.1.103]
xref: EC:4.2.1.103
xref: KEGG:R05771
xref: MetaCyc:4.2.1.103-RXN
xref: RHEA:18200
xref: UM-BBD_reactionID:r1029
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050550
name: pinene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranyl diphosphate = pinene + diphosphate." [EC:4.2.3.14, MetaCyc:4.2.3.14-RXN]
synonym: "(-)-(1S,5S)-pinene synthase activity" EXACT [EC:4.2.3.14]
synonym: "beta-geraniolene synthase activity" EXACT [EC:4.2.3.14]
synonym: "geranyl-diphosphate diphosphate-lyase (cyclizing, pinene-forming)" EXACT [EC:4.2.3.14]
synonym: "geranyldiphosphate diphosphate lyase (pinene forming)" EXACT [EC:4.2.3.14]
xref: EC:4.2.3.14
xref: MetaCyc:4.2.3.14-RXN
is_a: GO:0010333 ! terpene synthase activity

[Term]
id: GO:0050551
name: myrcene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranyl diphosphate = diphosphate + myrcene." [EC:4.2.3.15, RHEA:16968]
synonym: "geranyl-diphosphate diphosphate-lyase (myrcene-forming) activity" EXACT []
xref: EC:4.2.3.15
xref: KEGG:R02009
xref: MetaCyc:RXN-5110
xref: RHEA:16968
is_a: GO:0010333 ! terpene synthase activity

[Term]
id: GO:0050552
name: (4S)-limonene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranyl diphosphate = (4S)-limonene + diphosphate." [EC:4.2.3.16, MetaCyc:4.2.3.16-RXN]
synonym: "(-)-(4S)-limonene synthase activity" EXACT []
synonym: "4S-(-)-limonene synthase activity" EXACT [EC:4.2.3.16]
synonym: "geranyl-diphosphate diphosphate-lyase [cyclizing, (-)-(4S)-limonene-forming]" RELATED [EC:4.2.3.16]
synonym: "geranyldiphosphate diphosphate lyase (limonene forming)" EXACT [EC:4.2.3.16]
synonym: "geranyldiphosphate diphosphate lyase [cyclizing, (4S)-limonene-forming]" RELATED [EC:4.2.3.16]
xref: EC:4.2.3.16
xref: MetaCyc:4.2.3.16-RXN
xref: RHEA:12872
is_a: GO:0010333 ! terpene synthase activity

[Term]
id: GO:0050553
name: taxadiene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = diphosphate + taxa-4,11-diene." [EC:4.2.3.17, RHEA:20915]
synonym: "geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, taxa-4,11-diene-forming)" EXACT [EC:4.2.3.17]
synonym: "geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, taxadiene-forming)" EXACT [EC:4.2.3.17]
synonym: "taxa-4(5),11(12)-diene synthase activity" EXACT [EC:4.2.3.17]
xref: EC:4.2.3.17
xref: KEGG:R06305
xref: MetaCyc:4.2.3.17-RXN
xref: RHEA:20915
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0050554
name: abietadiene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (+)-copalyl diphosphate = (-)-abietadiene + diphosphate." [EC:4.2.3.18, RHEA:13876]
synonym: "(+)-copalyl-diphosphate diphosphate-lyase (cyclizing, (-)-abietadiene-forming)" EXACT [EC:4.2.3.18]
synonym: "abietadiene cyclase activity" EXACT [EC:4.2.3.18]
synonym: "copalyl-diphosphate diphosphate-lyase (cyclizing)" EXACT [EC:4.2.3.18]
xref: EC:4.2.3.18
xref: KEGG:R06301
xref: MetaCyc:4.2.3.18-RXN
xref: RHEA:13876
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0050555
name: 2-hydroxypropyl-CoM lyase activity
namespace: molecular_function
def: "Catalysis of the reactions: (R)-2-hydroxypropyl-CoM = H-S-CoM + (R)-1,2-epoxypropane, and (S)-2-hydroxypropyl-CoM = H-S-CoM + (S)-1,2-epoxypropane." [EC:4.2.99.19, MetaCyc:4.2.99.19-RXN]
subset: gosubset_prok
synonym: "(R)-2-hydroxypropyl-CoM 2-mercaptoethanesulfonate lyase (cyclizing; epoxyalkane-ring-forming)" EXACT [EC:4.4.1.23]
synonym: "(R)-[or (S)-]2-hydroxypropyl-CoM:2-mercaptoethanesulfonate lyase (epoxyalkane-ring-forming)" EXACT [EC:4.4.1.23]
synonym: "2-hydroxypropyl-CoM:2-mercaptoethanesulfonate lyase (epoxyalkane-ring-forming)" EXACT [EC:4.4.1.23]
synonym: "coenzyme M-epoxyalkane ligase activity" EXACT [EC:4.4.1.23]
synonym: "EaCoMT activity" EXACT [EC:4.4.1.23]
synonym: "epoxyalkane:2-mercaptoethanesulfonate transferase activity" EXACT [EC:4.4.1.23]
synonym: "epoxyalkane:coenzyme M transferase activity" EXACT [EC:4.4.1.23]
synonym: "epoxyalkane:CoM transferase activity" EXACT [EC:4.4.1.23]
synonym: "epoxyalkyl:CoM transferase activity" EXACT [EC:4.4.1.23]
synonym: "epoxypropane:coenzyme M transferase activity" EXACT [EC:4.4.1.23]
synonym: "epoxypropyl:CoM transferase activity" EXACT [EC:4.4.1.23]
xref: EC:4.4.1.23
xref: MetaCyc:4.2.99.19-RXN
xref: UM-BBD_enzymeID:e0538
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0050556
name: deacetylisoipecoside synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: deacetylisoipecoside + H(2)O = dopamine + secologanin." [EC:4.3.3.3, RHEA:21759]
synonym: "deacetylisoipecoside dopamine-lyase (secologanin-forming)" EXACT [EC:4.3.3.3]
synonym: "deacetylisoipecoside dopamine-lyase activity" EXACT [EC:4.3.3.3]
xref: EC:4.3.3.3
xref: KEGG:R05750
xref: MetaCyc:4.3.3.3-RXN
xref: RHEA:21759
is_a: GO:0016843 ! amine-lyase activity

[Term]
id: GO:0050557
name: deacetylipecoside synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: deacetylipecoside + H(2)O = dopamine + secologanin." [EC:4.3.3.4, RHEA:12299]
synonym: "deacetylipecoside dopamine-lyase (secologanin-forming)" EXACT [EC:4.3.3.4]
synonym: "deacetylipecoside dopamine-lyase activity" EXACT [EC:4.3.3.4]
xref: EC:4.3.3.4
xref: KEGG:R05749
xref: MetaCyc:4.3.3.4-RXN
xref: RHEA:12299
is_a: GO:0016843 ! amine-lyase activity

[Term]
id: GO:0050558
name: maltose epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-maltose = beta-maltose." [EC:5.1.3.21, RHEA:21231]
synonym: "maltose 1-epimerase activity" EXACT [EC:5.1.3.21]
xref: EC:5.1.3.21
xref: KEGG:R07319
xref: MetaCyc:5.1.3.21-RXN
xref: RHEA:21231
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0050559
name: copalyl diphosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = (+)-copalyl diphosphate." [EC:5.5.1.12, RHEA:24319]
synonym: "(+)-copalyl-diphosphate lyase (decyclizing)" EXACT [EC:5.5.1.12]
synonym: "diterpene cyclase activity" BROAD []
xref: EC:5.5.1.12
xref: KEGG:R06298
xref: MetaCyc:RXN-4861
xref: RHEA:24319
is_a: GO:0016872 ! intramolecular lyase activity

[Term]
id: GO:0050560
name: aspartate-tRNA(Asn) ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: tRNA(Asx) + L-aspartate + ATP = aspartyl-tRNA(Asx) + diphosphate + AMP." [EC:6.1.1.23, MetaCyc:6.1.1.23-RXN]
synonym: "aspartate-tRNAAsn ligase activity" EXACT []
synonym: "L-aspartate:tRNAAsx ligase (AMP-forming)" EXACT [EC:6.1.1.23]
synonym: "nondiscriminating aspartyl-tRNA synthetase activity" RELATED [EC:6.1.1.23]
xref: EC:6.1.1.23
xref: MetaCyc:6.1.1.23-RXN
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0050561
name: glutamate-tRNA(Gln) ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: tRNA(Glx) + L-glutamate + ATP = glutamyl-tRNA(Glx) + diphosphate + AMP." [EC:6.1.1.24, MetaCyc:6.1.1.24-RXN]
synonym: "glutamate-tRNAGln ligase activity" EXACT []
synonym: "L-glutamate:tRNAGlx ligase (AMP-forming)" EXACT [EC:6.1.1.24]
synonym: "nondiscriminating glutamyl-tRNA synthetase activity" RELATED [EC:6.1.1.24]
xref: EC:6.1.1.24
xref: MetaCyc:6.1.1.24-RXN
xref: RHEA:18400
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0050562
name: lysine-tRNA(Pyl) ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: tRNA(Pyl) + L-lysine + ATP = L-lysyl-tRNA(Pyl) + diphosphate + AMP." [EC:6.1.1.25, MetaCyc:6.1.1.25-RXN]
synonym: "L-lysine:tRNAPyl ligase (AMP-forming)" EXACT [EC:6.1.1.25]
synonym: "lysine-tRNAPyl ligase activity" EXACT []
xref: EC:6.1.1.25
xref: MetaCyc:6.1.1.25-RXN
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0050563
name: trans-feruloyl-CoA synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ferulic acid + CoASH + ATP = trans-feruloyl-CoA + products of ATP breakdown." [EC:6.2.1.34, MetaCyc:6.2.1.34-RXN]
synonym: "trans-ferulate:CoASH ligase (ATP-hydrolysing)" EXACT [EC:6.2.1.34]
synonym: "trans-feruloyl-CoA synthetase activity" EXACT [EC:6.2.1.34]
xref: EC:6.2.1.34
xref: MetaCyc:6.2.1.34-RXN
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0050564
name: N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-2-aminoadipate + L-cysteine + L-valine + 3 ATP + H(2)O = N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + 3 AMP + 3 diphosphate + 6 H(+)." [EC:6.3.2.26, RHEA:23199]
subset: gosubset_prok
synonym: "ACV synthetase activity" BROAD [EC:6.3.2.26]
synonym: "L-2-aminohexanedioate:L-cysteine:L-valine ligase (AMP-forming, valine-inverting)" EXACT [EC:6.3.2.26]
synonym: "L-alpha-aminoadipyl-cysteinyl-valine synthetase activity" EXACT [EC:6.3.2.26]
synonym: "L-delta-(alpha-aminoadipoyl)-L-cysteinyl-D-valine synthetase activity" EXACT [EC:6.3.2.26]
xref: EC:6.3.2.26
xref: KEGG:R04870
xref: MetaCyc:6.3.2.26-RXN
xref: RHEA:23199
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0050565
name: aerobactin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 N(6)-acetyl-N(6)-hydroxy-L-lysine + 4 ATP + citrate + 2 H(2)O = 4 ADP + aerobactin + 8 H(+) + 4 phosphate." [EC:6.3.2.27, RHEA:11763]
synonym: "citrate:6-N-acetyl-6-N-hydroxy-L-lysine ligase (ADP-forming)" EXACT [EC:6.3.2.27]
synonym: "citrate:N6-acetyl-N6-hydroxy-L-lysine ligase (ADP-forming)" EXACT [EC:6.3.2.27]
xref: EC:6.3.2.27
xref: KEGG:R04357
xref: MetaCyc:6.3.2.27-RXN
xref: RHEA:11763
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0050566
name: asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamine + aspartyl-tRNA(Asn) + ATP = L-glutamate + asparaginyl-tRNA(Asn) + phosphate + ADP." [EC:6.3.5.6, MetaCyc:6.3.5.6-RXN]
synonym: "Asp-AdT activity" EXACT [EC:6.3.5.6]
synonym: "Asp-tRNA(Asn) amidotransferase activity" EXACT [EC:6.3.5.6]
synonym: "Asp-tRNAAsn amidotransferase activity" EXACT [EC:6.3.5.6]
synonym: "Asp-tRNAAsn:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.6]
synonym: "asparaginyl-tRNA synthase (glutamine-hydrolysing)" EXACT [EC:6.3.5.6]
synonym: "aspartyl-tRNA(Asn) amidotransferase activity" EXACT [EC:6.3.5.6]
synonym: "aspartyl-tRNAAsn amidotransferase activity" EXACT [EC:6.3.5.6]
synonym: "aspartyl-tRNAAsn:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.6]
xref: EC:6.3.5.6
xref: MetaCyc:6.3.5.6-RXN
xref: RHEA:14516
xref: Wikipedia:Asparaginyl-tRNA_synthase_(glutamine-hydrolysing)
is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor

[Term]
id: GO:0050567
name: glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity
namespace: molecular_function
alt_id: GO:0008264
alt_id: GO:0017068
def: "Catalysis of the reaction: L-glutamine + glutamyl-tRNA(Gln) + ATP = L-glutamate + glutaminyl-tRNA(Gln) + phosphate + ADP." [EC:6.3.5.7, MetaCyc:6.3.5.7-RXN]
subset: gosubset_prok
synonym: "Glu-AdT activity" EXACT [EC:6.3.5.-]
synonym: "Glu-tRNA(Gln) amidotransferase activity" EXACT [EC:6.3.5.-]
synonym: "Glu-tRNAGln amidotransferase activity" EXACT [EC:6.3.5.7]
synonym: "Glu-tRNAGln:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.7]
synonym: "glutaminyl-tRNA synthase (glutamine-hydrolysing)" EXACT [EC:6.3.5.7]
synonym: "glutamyl-tRNA(Gln) amidotransferase activity" EXACT [EC:6.3.5.-]
synonym: "glutamyl-tRNAGln amidotransferase activity" EXACT [EC:6.3.5.7]
synonym: "glutamyl-tRNAGln:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.7]
xref: EC:6.3.5.7
xref: MetaCyc:6.3.5.7-RXN
xref: RHEA:17524
xref: Wikipedia:Glutaminyl-tRNA_synthase_(glutamine-hydrolysing)
is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor

[Term]
id: GO:0050568
name: protein-glutamine glutaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein L-glutamine + H2O = protein L-glutamate + NH3." [EC:3.5.1.44, MetaCyc:CHEBDEAMID-RXN]
synonym: "destabilase activity" EXACT [EC:3.5.1.44]
synonym: "glutaminyl-peptide glutaminase activity" EXACT [EC:3.5.1.44]
synonym: "glutaminylpeptide glutaminase activity" EXACT [EC:3.5.1.44]
synonym: "peptidoglutaminase II activity" RELATED [EC:3.5.1.44]
synonym: "peptidylglutaminase II" RELATED [EC:3.5.1.44]
synonym: "protein-L-glutamine amidohydrolase activity" EXACT [EC:3.5.1.44]
xref: EC:3.5.1.44
xref: MetaCyc:CHEBDEAMID-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050569
name: glycolaldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycolaldehyde + H(2)O + NAD(+) = glycolate + 2 H(+) + NADH." [EC:1.2.1.21, RHEA:20004]
subset: gosubset_prok
synonym: "glycol aldehyde dehydrogenase activity" EXACT [EC:1.2.1.21]
synonym: "glycolaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.21]
xref: EC:1.2.1.21
xref: KEGG:R01333
xref: MetaCyc:GLYCOLALD-DEHYDROG-RXN
xref: RHEA:20004
is_a: GO:0004029 ! aldehyde dehydrogenase (NAD) activity

[Term]
id: GO:0050570
name: 4-hydroxythreonine-4-phosphate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-(phosphonooxy)-threonine + NAD+ = 2-amino-3-oxo-4-phosphonooxybutyrate + NADH + H+." [EC:1.1.1.262, MetaCyc:1.1.1.262-RXN]
subset: gosubset_prok
synonym: "4-(phosphohydroxy)-L-threonine dehydrogenase activity" EXACT [EC:1.1.1.262]
synonym: "4-(phosphonooxy)-L-threonine:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.262]
synonym: "L-threonine 4-phosphate dehydrogenase activity" EXACT [EC:1.1.1.262]
synonym: "NAD(+)-dependent threonine 4-phosphate dehydrogenase activity" EXACT [EC:1.1.1.262]
synonym: "NAD+-dependent threonine 4-phosphate dehydrogenase activity" EXACT [EC:1.1.1.262]
synonym: "PdxA" RELATED [EC:1.1.1.262]
xref: EC:1.1.1.262
xref: MetaCyc:1.1.1.262-RXN
xref: RHEA:25319
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050571
name: 1,5-anhydro-D-fructose reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,5-anhydro-D-glucitol + NADP(+) = 1,5-anhydro-D-fructose + H(+) + NADPH." [EC:1.1.1.263, RHEA:20668]
synonym: "1,5-anhydro-D-glucitol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.263]
synonym: "AF reductase activity" EXACT [EC:1.1.1.263]
xref: EC:1.1.1.263
xref: KEGG:R05682
xref: MetaCyc:1.1.1.263-RXN
xref: RHEA:20668
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050572
name: L-idonate 5-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-idonate + NAD(P)+ = 5-dehydrogluconate + NAD(P)H + H+." [EC:1.1.1.264, MetaCyc:1.1.1.264-RXN]
subset: gosubset_prok
synonym: "L-idonate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.264]
xref: EC:1.1.1.264
xref: MetaCyc:1.1.1.264-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050573
name: dTDP-4-dehydro-6-deoxyglucose reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: dTDP-D-fucose + NADP(+) = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH." [EC:1.1.1.266, RHEA:21903]
synonym: "dTDP-4-keto-6-deoxyglucose reductase activity" EXACT [EC:1.1.1.266]
synonym: "dTDP-D-fucose:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.266]
xref: EC:1.1.1.266
xref: KEGG:R05687
xref: MetaCyc:1.1.1.266-RXN
xref: RHEA:21903
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050574
name: 2-(R)-hydroxypropyl-CoM dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-(R)-hydroxypropyl-coenzyme M + NAD(+) = 2-oxopropyl-coenzyme M + H(+) + NADH." [EC:1.1.1.268, RHEA:13252]
subset: gosubset_prok
synonym: "2-(2-(R)-hydroxypropylthio)ethanesulfonate dehydrogenase activity" EXACT [EC:1.1.1.268]
synonym: "2-[2-(R)-hydroxypropylthio]ethanesulfonate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.268]
xref: EC:1.1.1.268
xref: KEGG:R05689
xref: MetaCyc:1.1.1.268-RXN
xref: RHEA:13252
xref: UM-BBD_reactionID:r0852
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050575
name: 2-(S)-hydroxypropyl-CoM dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-(S)-hydroxypropyl-coenzyme M + NAD(+) = 2-oxopropyl-coenzyme M + H(+) + NADH." [EC:1.1.1.269, RHEA:21055]
subset: gosubset_prok
synonym: "2-(2-(S)-hydroxypropylthio)ethanesulfonate dehydrogenase activity" EXACT [EC:1.1.1.269]
synonym: "2-[2-(S)-hydroxypropylthio]ethanesulfonate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.269]
xref: EC:1.1.1.269
xref: KEGG:R05690
xref: MetaCyc:1.1.1.269-RXN
xref: RHEA:21055
xref: UM-BBD_reactionID:r0853
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050577
name: GDP-L-fucose synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-L-fucose + NAD+ = GDP-4-dehydro-6-deoxy-D-mannose + NADH + H+." [EC:1.1.1.271, MetaCyc:1.1.1.271-RXN]
subset: gosubset_prok
synonym: "GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase activity" EXACT [EC:1.1.1.271]
synonym: "GDP-fucose synthetase activity" EXACT [EC:1.1.1.271]
synonym: "GDP-L-fucose:NADP+ 4-oxidoreductase (3,5-epimerizing)" EXACT [EC:1.1.1.271]
xref: EC:1.1.1.271
xref: MetaCyc:1.1.1.271-RXN
xref: RHEA:18888
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
relationship: part_of GO:0042350 ! GDP-L-fucose biosynthetic process

[Term]
id: GO:0050578
name: (R)-2-hydroxyacid dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-3-sulfolactate + NAD(P)+ = 3-sulfopyruvate + NAD(P)H + H+." [EC:1.1.1.272, MetaCyc:1.1.1.272-RXN]
subset: gosubset_prok
synonym: "(R)-2-hydroxyacid:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.272]
synonym: "(R)-sulfolactate:NAD(P)(+) oxidoreductase activity" EXACT [EC:1.1.1.272]
synonym: "(R)-sulfolactate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.272]
synonym: "L-sulfolactate dehydrogenase activity" EXACT [EC:1.1.1.272]
xref: EC:1.1.1.272
xref: MetaCyc:1.1.1.272-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050579
name: vellosimine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 10-deoxysarpagine + NADP(+) = H(+) + NADPH + vellosimine." [EC:1.1.1.273, RHEA:20032]
synonym: "10-deoxysarpagine:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.273]
xref: EC:1.1.1.273
xref: KEGG:R05827
xref: MetaCyc:1.1.1.273-RXN
xref: RHEA:20032
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050580
name: 2,5-didehydrogluconate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-dehydro-D-gluconate + NADP+ = 2,5-didehydro-D-gluconate + NADPH + H+." [EC:1.1.1.274, MetaCyc:1.1.1.274-RXN]
subset: gosubset_prok
synonym: "2,5-diketo-D-gluconate reductase activity" EXACT [EC:1.1.1.274]
synonym: "2-dehydro-D-gluconate:NADP+ 2-oxidoreductase activity" EXACT [EC:1.1.1.274]
synonym: "YqhE reductase" RELATED [EC:1.1.1.274]
xref: EC:1.1.1.274
xref: MetaCyc:1.1.1.274-RXN
xref: RHEA:23831
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050581
name: D-mannitol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: mannitol + O2 = mannose + H2O2." [EC:1.1.3.40, MetaCyc:1.1.3.40-RXN]
synonym: "D-arabinitol oxidase activity" RELATED [EC:1.1.3.40]
synonym: "D-arabitol oxidase activity" EXACT [EC:1.1.3.40]
synonym: "mannitol oxidase activity" EXACT [EC:1.1.3.40]
synonym: "mannitol:oxygen oxidoreductase (cyclizing)" EXACT [EC:1.1.3.40]
xref: EC:1.1.3.40
xref: MetaCyc:1.1.3.40-RXN
xref: RHEA:18516
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0050582
name: xylitol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: xylitol + O2 = xylose + H2O2." [EC:1.1.3.41, MetaCyc:1.1.3.41-RXN]
subset: gosubset_prok
synonym: "xylitol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.41]
xref: EC:1.1.3.41
xref: MetaCyc:1.1.3.41-RXN
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0050583
name: hydrogen dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + H2 = NADPH + H+." [EC:1.12.1.3, MetaCyc:1.12.1.3-RXN]
synonym: "hydrogen:NADP+ oxidoreductase activity" EXACT [EC:1.12.1.3]
synonym: "NADP-linked hydrogenase activity" RELATED [EC:1.12.1.3]
synonym: "NADP-reducing hydrogenase activity" RELATED [EC:1.12.1.3]
xref: EC:1.12.1.3
xref: MetaCyc:1.12.1.3-RXN
xref: RHEA:18640
is_a: GO:0016696 ! oxidoreductase activity, acting on hydrogen as donor, NAD or NADP as acceptor

[Term]
id: GO:0050584
name: linoleate 11-lipoxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: linoleate + O(2) = (9Z,11S,12Z)-11-hydroperoxyoctadeca-9,12-dienoate." [EC:1.13.11.45, RHEA:18996]
synonym: "linoleate dioxygenase activity" EXACT [EC:1.13.11.45]
synonym: "linoleate:oxygen 11S-oxidoreductase activity" EXACT [EC:1.13.11.45]
synonym: "manganese lipoxygenase activity" EXACT [EC:1.13.11.45]
xref: EC:1.13.11.45
xref: KEGG:R05718
xref: MetaCyc:1.13.11.45-RXN
xref: RHEA:18996
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0050585
name: 4-hydroxymandelate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = 4-hydroxymandelate + CO2." [EC:1.13.11.46, MetaCyc:1.13.11.46-RXN]
synonym: "4-hydroxyphenylpyruvate dioxygenase II activity" NARROW [EC:1.13.11.46]
synonym: "4-hydroxyphenylpyruvate:oxygen oxidoreductase (decarboxylating)" BROAD [EC:1.13.11.46]
xref: EC:1.13.11.46
xref: MetaCyc:1.13.11.46-RXN
xref: RHEA:21379
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0050586
name: 3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxy-2-methylquinolin-4(1H)-one + H(+) + O(2) = N-acetylanthranilate + CO." [EC:1.13.11.48, RHEA:21575]
subset: gosubset_prok
synonym: "(1H)-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase activity" EXACT [EC:1.13.11.48]
synonym: "1H-3-hydroxy-4-oxo quinaldine 2,4-dioxygenase activity" EXACT []
synonym: "1H-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase activity" EXACT []
synonym: "3-hydroxy-2-methyl-1H-quinolin-4-one 2,4-dioxygenase (CO-forming)" EXACT [EC:1.13.11.48]
synonym: "3-hydroxy-2-methyl-quinolin-4-one 2,4-dioxygenase activity" EXACT []
xref: EC:1.13.11.48
xref: KEGG:R05720
xref: MetaCyc:1.13.11.48-RXN
xref: RHEA:21575
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0050587
name: chlorite O2-lyase activity
namespace: molecular_function
alt_id: GO:0030065
def: "Catalysis of the reaction: chloride + O(2) = chlorite." [EC:1.13.11.49, RHEA:21407]
synonym: "chloride:oxygen oxidoreductase activity" EXACT [EC:1.13.11.49]
synonym: "chlorite dismutase activity" EXACT [EC:1.13.11.49]
xref: EC:1.13.11.49
xref: KEGG:R05721
xref: MetaCyc:1.13.11.49-RXN
xref: RHEA:21407
xref: UM-BBD_reactionID:r0982
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0050588
name: apo-beta-carotenoid-14',13'-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 8'-apo-beta-carotenol + O(2) = (E,E)-7-hydroxy-6-methylhepta-3,5-dienal + 14'-apo-beta-carotenal." [EC:1.13.12.12, RHEA:26026]
synonym: "8'-apo-beta-carotenol:O2 oxidoreductase activity" EXACT [EC:1.13.12.12]
synonym: "apo-b-carotenoid-14',13'-dioxygenase activity" EXACT []
xref: EC:1.13.12.12
xref: KEGG:R08889
xref: MetaCyc:1.13.12.12-RXN
xref: RHEA:26026
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)

[Term]
id: GO:0050589
name: leucocyanidin oxygenase activity
namespace: molecular_function
alt_id: GO:0045432
def: "Catalysis of the reaction: leucocyanidin + 2-oxoglutarate + O2 = cis- or trans-dihydroquercetin + succinate + CO2 + 2 H2O." [EC:1.14.11.19, MetaCyc:1.14.11.19-RXN]
synonym: "anthocyanidin synthase activity" RELATED [EC:1.14.11.19]
synonym: "leucoanthocyanidin dioxygenase activity" EXACT [EC:1.14.11.19]
synonym: "leucoanthocyanidin hydroxylase" RELATED [EC:1.14.11.19]
synonym: "leucocyanidin,2-oxoglutarate:oxygen oxidoreductase activity" EXACT [EC:1.14.11.19]
xref: EC:1.14.11.19
xref: MetaCyc:RXN-602
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0050590
name: desacetoxyvindoline 4-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: desacetoxyvindoline + 2-oxoglutarate + O2 = desacetylvindoline + succinate + CO2." [EC:1.14.11.20, MetaCyc:1.14.11.20-RXN]
synonym: "D17H activity" RELATED [EC:1.14.11.20]
synonym: "deacetoxyvindoline,2-oxoglutarate:oxygen oxidoreductase (4beta-hydroxylating)" EXACT [EC:1.14.11.20]
synonym: "desacetoxyvindoline,2-oxoglutarate:oxygen oxidoreductase (4-beta-hydroxylating) activity" EXACT [EC:1.14.11.20]
synonym: "desacetoxyvindoline,2-oxoglutarate:oxygen oxidoreductase (4beta-hydroxylating)" EXACT [EC:1.14.11.20]
synonym: "desacetoxyvindoline-4-hydroxylase activity" EXACT [EC:1.14.11.20]
synonym: "desacetyoxyvindoline-17-hydroxylase activity" EXACT [EC:1.14.11.20]
xref: EC:1.14.11.20
xref: KEGG:R05857
xref: MetaCyc:1.14.11.20-RXN
xref: RHEA:18976
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0050591
name: quinine 3-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(+) + NADPH + O(2) + quinine = 3-hydroxyquinine + H(2)O + NADP(+)." [EC:1.14.13.67, RHEA:20152]
synonym: "nifedipine oxidase activity" EXACT [EC:1.14.13.67]
synonym: "quinine 3-hydroxylase activity" EXACT []
synonym: "quinine,NADPH:oxygen oxidoreductase activity" EXACT [EC:1.14.13.67]
xref: EC:1.14.13.67
xref: KEGG:R05727
xref: MetaCyc:1.14.13.67-RXN
xref: RHEA:20152
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050592
name: 4-hydroxyphenylacetaldehyde oxime monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (Z)-(4-hydroxyphenyl)acetaldehyde oxime + H(+) + NADPH + O(2) = (S)-4-hydroxymandelonitrile + 2 H(2)O + NADP(+)." [EC:1.14.13.68, RHEA:18404]
synonym: "(Z)-4-hydroxyphenylacetaldehyde oxime,NADPH:oxygen oxidoreductase activity" EXACT [EC:1.14.13.68]
synonym: "4-hydroxybenzeneacetaldehyde oxime monooxygenase activity" EXACT [EC:1.14.13.68]
synonym: "4-hydroxyphenylacetaldehyde oxime,NADPH:oxygen oxidoreductase activity" EXACT [EC:1.14.13.68]
synonym: "CYP71E1 activity" NARROW [EC:1.14.13.68]
synonym: "cytochrome P450-II-dependent monooxygenase activity" NARROW [EC:1.14.13.68]
synonym: "cytochrome P450II-dependent monooxygenase activity" EXACT [EC:1.14.13.68]
synonym: "NADPH-cytochrome P450 reductase (CYP71E1)" EXACT [EC:1.14.13.68]
xref: EC:1.14.13.68
xref: KEGG:R05728
xref: MetaCyc:1.14.13.68-RXN
xref: RHEA:18404
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050593
name: N-methylcoclaurine 3'-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-N-methylcoclaurine + H(+) + NADPH + O(2) = (S)-3'-hydroxy-N-methylcoclaurine + H(2)O + NADP(+)." [EC:1.14.13.71, RHEA:16652]
synonym: "(S)-N-methylcoclaurine 3'-hydroxylase activity" EXACT [EC:1.14.13.71]
synonym: "(S)-N-methylcoclaurine,NADPH:oxygen oxidoreductase (3'-hydroxylating)" EXACT [EC:1.14.13.71]
synonym: "cytochrome P450 80B1 activity" EXACT [EC:1.14.13.71]
synonym: "N-methylcoclaurine 3'-hydroxylase activity" EXACT []
xref: EC:1.14.13.71
xref: KEGG:R05732
xref: MetaCyc:1.14.13.71-RXN
xref: RHEA:16652
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050594
name: tabersonine 16-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(+) + NADPH + O(2) + tabersonine = 16-hydroxytabersonine + H(2)O + NADP(+)." [EC:1.14.13.73, RHEA:14136]
synonym: "tabersonine,NADPH:oxygen oxidoreductase (16-hydroxylating)" EXACT [EC:1.14.13.73]
xref: EC:1.14.13.73
xref: KEGG:R05855
xref: MetaCyc:1.14.13.73-RXN
xref: RHEA:14136
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050595
name: 7-deoxyloganin 7-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7-deoxyloganin + NADPH + H+ + O2 = loganin + NADP+ + H2O." [EC:1.14.13.74, MetaCyc:1.14.13.74-RXN]
synonym: "7-deoxyloganin,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)" EXACT [EC:1.14.13.74]
xref: EC:1.14.13.74
xref: MetaCyc:1.14.13.74-RXN
xref: RHEA:11455
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050596
name: vinorine hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(+) + NADPH + O(2) + vinorine = H(2)O + NADP(+) + vomilenine." [EC:1.14.13.75, RHEA:17260]
synonym: "vinorine,NADPH:oxygen oxidoreductase (21alpha-hydroxylating)" EXACT [EC:1.14.13.75]
xref: EC:1.14.13.75
xref: KEGG:R05877
xref: MetaCyc:1.14.13.75-RXN
xref: RHEA:17260
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050597
name: taxane 10-beta-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(+) + NADPH + O(2) + taxa-4(20),11-dien-5alpha-yl acetate = 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(2)O + NADP(+)." [EC:1.14.13.76, RHEA:15244]
synonym: "5-alpha-taxadienol-10-beta-hydroxylase activity" EXACT [EC:1.14.13.76]
synonym: "taxa-4(20),11-dien-5alpha-yl acetate,NADPH:oxygen oxidoreductase (10beta-hydroxylating)" EXACT [EC:1.14.13.76]
synonym: "taxane 10b-hydroxylase activity" EXACT []
synonym: "taxane 10beta-hydroxylase activity" EXACT [EC:1.14.13.76]
xref: EC:1.14.13.76
xref: KEGG:R06309
xref: MetaCyc:1.14.13.76-RXN
xref: RHEA:15244
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050598
name: taxane 13-alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(+) + NADPH + O(2) + taxa-4(20),11-dien-5alpha-ol = H(2)O + NADP(+) + taxa-4(20),11-dien-5alpha,13alpha-diol." [EC:1.14.13.77, RHEA:18952]
synonym: "taxa-4(20),11-dien-5alpha-ol,NADPH:oxygen oxidoreductase (13alpha-hydroxylating)" EXACT [EC:1.14.13.77]
synonym: "taxane 13a-hydroxylase activity" EXACT []
synonym: "taxane 13alpha-hydroxylase activity" EXACT [EC:1.14.13.77]
xref: EC:1.14.13.77
xref: KEGG:R06308
xref: MetaCyc:1.14.13.77-RXN
xref: RHEA:18952
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050599
name: deacetoxycephalosporin-C synthase activity
namespace: molecular_function
alt_id: GO:0045441
def: "Catalysis of the reaction: 2-oxoglutarate + O(2) + penicillin N = CO(2) + deacetoxycephalosporin C + H(2)O + succinate." [EC:1.14.20.1, RHEA:20751]
subset: gosubset_prok
synonym: "DAOC synthase activity" EXACT [EC:1.14.20.1]
synonym: "DAOCS activity" EXACT [EC:1.14.20.1]
synonym: "deacetoxycephalosporin C synthetase activity" EXACT []
synonym: "expandase activity" EXACT []
synonym: "penicillin N expandase activity" RELATED [EC:1.14.20.1]
synonym: "penicillin-N,2-oxoglutarate:oxygen oxidoreductase (ring-expanding)" EXACT [EC:1.14.20.1]
xref: EC:1.14.20.1
xref: KEGG:R05301
xref: MetaCyc:1.14.20.1-RXN
xref: RHEA:20751
is_a: GO:0050498 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with 2-oxoglutarate as one donor, and the other dehydrogenated

[Term]
id: GO:0050600
name: myristoyl-CoA 11-(E) desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: myristoyl-CoA + NAD(P)H + H+ + O2 = (E)-11-tetradecenoyl-CoA + NAD(P)+ + 2 H2O." [EC:1.14.99.31, MetaCyc:1.14.99.31-RXN]
synonym: "n-tetradecanoyl-CoA,NAD(P)H:O2 oxidoreductase [11-(E) desaturating]" RELATED [EC:1.14.99.31]
synonym: "n-tetradecanoyl-CoA,NADPH:O2 oxidoreductase [11-(E) desaturating]" RELATED [EC:1.14.99.31]
xref: EC:1.14.99.31
xref: MetaCyc:1.14.99.31-RXN
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0050601
name: myristoyl-CoA 11-(Z) desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: myristoyl-CoA + NAD(P)H + H+ + O2 = (Z)-11-tetradecenoyl-CoA + NAD(P)+ + 2 H2O." [EC:1.14.99.32, MetaCyc:1.14.99.32-RXN]
synonym: "n-tetradecanoyl-CoA,NAD(P)H:O2 oxidoreductase [11-(Z) desaturating]" RELATED [EC:1.14.99.32]
synonym: "n-tetradecanoyl-CoA,NADPH:O2 oxidoreductase [11-(Z) desaturating]" RELATED [EC:1.14.99.32]
xref: EC:1.14.99.32
xref: MetaCyc:1.14.99.32-RXN
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0050602
name: monoprenyl isoflavone epoxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + NADPH + H+ + 7-O-methylluteone = H2O + NADP+ + dihydrofurano derivatives." [EC:1.14.99.34, MetaCyc:1.14.99.34-RXN]
synonym: "7-O-methylluteone,NADPH:O2 oxidoreductase activity" EXACT [EC:1.14.99.34]
synonym: "7-O-methylluteone:O2 oxidoreductase activity" EXACT [EC:1.14.99.34]
synonym: "monoprenyl isoflavone monooxygenase activity" EXACT [EC:1.14.99.34]
xref: EC:1.14.99.34
xref: MetaCyc:1.14.99.34-RXN
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0050603
name: thiophene-2-carbonyl-CoA monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: AH(2) + O(2) + thiophene-2-carbonyl-CoA = 5-hydroxythiophene-2-carbonyl-CoA + A + H(2)O + H(+)." [EC:1.14.99.35, RHEA:18932]
synonym: "thiophene-2-carbonyl-CoA, hydrogen-donor:oxygen oxidoreductase activity" EXACT [EC:1.14.99.35]
synonym: "thiophene-2-carboxyl-CoA dehydrogenase activity" EXACT [EC:1.14.99.35]
synonym: "thiophene-2-carboxyl-CoA hydroxylase activity" EXACT [EC:1.14.99.35]
synonym: "thiophene-2-carboxyl-CoA monooxygenase activity" EXACT [EC:1.14.99.35]
xref: EC:1.14.99.35
xref: KEGG:R05742
xref: MetaCyc:1.14.99.35-RXN
xref: RHEA:18932
xref: UM-BBD_reactionID:r1235
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0050604
name: taxadiene 5-alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: AH(2) + O(2) + taxa-4,11-diene = A + H(2)O + taxa-4(20),11-dien-5alpha-ol." [EC:1.14.99.37, RHEA:14052]
synonym: "taxa-4,11-diene,hydrogen-donor:oxygen oxidoreductase (5alpha-hydroxylating)" EXACT [EC:1.14.99.37]
synonym: "taxadiene 5a-hydroxylase activity" EXACT []
synonym: "taxadiene 5alpha-hydroxylase activity" EXACT [EC:1.14.99.37]
xref: EC:1.14.99.37
xref: KEGG:R06306
xref: MetaCyc:1.14.99.37-RXN
xref: RHEA:14052
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0050605
name: superoxide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: superoxide + reduced rubredoxin + 2 H+ = H2O2 + rubredoxin." [EC:1.15.1.2, MetaCyc:1.15.1.2-RXN]
subset: gosubset_prok
synonym: "desulfoferrodoxin activity" RELATED [EC:1.15.1.2]
synonym: "neelaredoxin activity" RELATED [EC:1.15.1.2]
synonym: "rubredoxin:superoxide oxidoreductase activity" EXACT [EC:1.15.1.2]
xref: EC:1.15.1.2
xref: MetaCyc:1.15.1.2-RXN
is_a: GO:0016209 ! antioxidant activity
is_a: GO:0016721 ! oxidoreductase activity, acting on superoxide radicals as acceptor

[Term]
id: GO:0050606
name: 4-carboxy-2-hydroxymuconate semialdehyde hemiacetal dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP(+) = 2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + NADPH." [RHEA:29590]
synonym: "2-hydroxy-4-carboxymuconate 6-semialdehyde dehydrogenase activity" EXACT [EC:1.1.1.312]
synonym: "4-carboxy-2-hydroxy-cis,cis-muconate-6-semialdehyde:NADP(+) oxidoreductase activity" EXACT [EC:1.1.1.312]
synonym: "4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase activity" EXACT [EC:1.1.1.312]
synonym: "alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase activity" EXACT [EC:1.1.1.312]
xref: EC:1.1.1.312
xref: KEGG:R04279
xref: MetaCyc:1.2.1.45-RXN
xref: RHEA:29590 "4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP(+) = 2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + NADPH"
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050607
name: mycothiol-dependent formaldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: formaldehyde + mycothiol + NAD+ = S-formylmycothiol + NADH + H+." [EC:1.2.1.66, MetaCyc:1.2.1.66-RXN]
subset: gosubset_prok
synonym: "formaldehyde:NAD+ oxidoreductase (mycothiol-formylating)" EXACT [EC:1.2.1.66]
synonym: "NAD/factor-dependent formaldehyde dehydrogenase activity" EXACT [EC:1.2.1.66]
xref: EC:1.2.1.66
xref: MetaCyc:1.2.1.66-RXN
xref: Reactome:REACT_27190 "mycothiol binds formaldehyde and is dehydrogenated, Mycobacterium tuberculosis"
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050608
name: vanillin dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + NAD(+) + vanillin = 2 H(+) + NADH + vanillate." [EC:1.2.1.67, RHEA:13312]
synonym: "vanillin:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.67]
xref: EC:1.2.1.67
xref: KEGG:R05699
xref: MetaCyc:1.2.1.67-RXN
xref: RHEA:13312
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050609
name: phosphonate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + NAD(+) + phosphonate = 2 H(+) + NADH + phosphate." [EC:1.20.1.1, RHEA:13176]
subset: gosubset_prok
synonym: "NAD-dependent phosphite dehydrogenas activity" EXACT [EC:1.20.1.1]
synonym: "NAD:phosphite oxidoreductase activity" EXACT [EC:1.20.1.1]
synonym: "phosphite dehydrogenase activity" EXACT [EC:1.20.1.1]
synonym: "phosphonate:NAD+ oxidoreductase activity" EXACT [EC:1.20.1.1]
xref: EC:1.20.1.1
xref: KEGG:R05746
xref: MetaCyc:1.20.1.1-RXN
xref: RHEA:13176
xref: UM-BBD_reactionID:r1055
is_a: GO:0050499 ! oxidoreductase activity, acting on phosphorus or arsenic in donors, with NAD(P)+ as acceptor

[Term]
id: GO:0050610
name: methylarsonate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 glutathione + H(+) + methylarsonate = glutathione disulfide + H(2)O + methylarsonous acid." [EC:1.20.4.2, RHEA:15972]
synonym: "gluthathione:methylarsonate oxidoreductase activity" EXACT [EC:1.20.4.2]
synonym: "MMA(V) reductase activity" EXACT [EC:1.20.4.2]
xref: EC:1.20.4.2
xref: KEGG:R05748
xref: MetaCyc:1.20.4.2-RXN
xref: RHEA:15972
xref: UM-BBD_reactionID:r0837
is_a: GO:0030614 ! oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor

[Term]
id: GO:0050611
name: arsenate reductase (azurin) activity
namespace: molecular_function
alt_id: GO:0018691
def: "Catalysis of the reaction: H(2)O + arsenite + 2 oxidized azurin = 2 H(+) + 2 reduced azurin + arsenate." [EC:1.20.9.1, MetaCyc:1.20.98.1-RXN]
subset: gosubset_prok
synonym: "arsenite oxidase activity" EXACT [EC:1.20.9.1]
synonym: "arsenite:azurin oxidoreductase activity" EXACT [EC:1.20.9.1]
xref: EC:1.20.9.1
xref: MetaCyc:1.20.98.1-RXN
xref: UM-BBD_reactionID:r0634
is_a: GO:0052882 ! oxidoreductase activity, acting on phosphorus or arsenic in donors, with a copper protein as acceptor

[Term]
id: GO:0050612
name: arsenate reductase (donor) activity
namespace: molecular_function
def: "Catalysis of the reaction: A + arsenite + H(2)O = AH(2) + arsenate + 2 H(+)." [EC:1.20.99.1, RHEA:18452]
synonym: "arsenate:(acceptor) oxidoreductase activity" EXACT [EC:1.20.99.1]
synonym: "arsenate:acceptor oxidoreductase activity" EXACT [EC:1.20.99.1]
xref: EC:1.20.99.1
xref: KEGG:R05752
xref: MetaCyc:1.20.99.1-RXN
xref: RHEA:18452
is_a: GO:0030613 ! oxidoreductase activity, acting on phosphorus or arsenic in donors

[Term]
id: GO:0050613
name: delta14-sterol reductase activity
namespace: molecular_function
alt_id: GO:0000251
def: "Catalysis of the reaction: NADP+ + 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol = NADPH + H+ + 4,4-dimethyl-5-alpha-cholesta-8,14,24-trien-3-beta-ol." [EC:1.3.1.70, MetaCyc:1.3.1.70-RXN]
comment: Note that zymosterol is cholesta-8,24-dien-3-ol.
synonym: "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol:NADP+ delta14-oxidoreductase activity" EXACT [EC:1.3.1.70]
synonym: "C-14 sterol reductase activity" EXACT []
synonym: "D14-sterol reductase activity" EXACT []
synonym: "sterol C-14 reductase activity" EXACT []
synonym: "sterol C14-reductase activity" EXACT [EC:1.3.1.70]
xref: EC:1.3.1.70
xref: MetaCyc:1.3.1.70-RXN
xref: Reactome:REACT_10081 "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2], Homo sapiens"
xref: Reactome:REACT_100840 "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR], Taeniopygia guttata"
xref: Reactome:REACT_103229 "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR], Dictyostelium discoideum"
xref: Reactome:REACT_104908 "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR], Mus musculus"
xref: Reactome:REACT_105788 "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2], Saccharomyces cerevisiae"
xref: Reactome:REACT_109461 "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR], Rattus norvegicus"
xref: Reactome:REACT_110089 "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2], Xenopus tropicalis"
xref: Reactome:REACT_113353 "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR], Drosophila melanogaster"
xref: Reactome:REACT_115123 "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2], Drosophila melanogaster"
xref: Reactome:REACT_77840 "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR], Oryza sativa"
xref: Reactome:REACT_78162 "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR], Arabidopsis thaliana"
xref: Reactome:REACT_84048 "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR], Danio rerio"
xref: Reactome:REACT_84067 "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR], Gallus gallus"
xref: Reactome:REACT_84076 "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR], Schizosaccharomyces pombe"
xref: Reactome:REACT_84647 "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2], Schizosaccharomyces pombe"
xref: Reactome:REACT_85361 "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2], Arabidopsis thaliana"
xref: Reactome:REACT_85449 "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2], Oryza sativa"
xref: Reactome:REACT_85695 "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2], Canis familiaris"
xref: Reactome:REACT_88036 "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR], Canis familiaris"
xref: Reactome:REACT_88073 "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2], Mus musculus"
xref: Reactome:REACT_90470 "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR], Saccharomyces cerevisiae"
xref: Reactome:REACT_91494 "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2], Dictyostelium discoideum"
xref: Reactome:REACT_91659 "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2], Danio rerio"
xref: Reactome:REACT_92161 "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2], Rattus norvegicus"
xref: Reactome:REACT_95974 "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2], Sus scrofa"
xref: Reactome:REACT_96585 "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR], Bos taurus"
xref: Reactome:REACT_98864 "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR], Xenopus tropicalis"
xref: Reactome:REACT_99055 "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2], Bos taurus"
xref: Reactome:REACT_9995 "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR], Homo sapiens"
xref: RHEA:18564
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050614
name: delta24-sterol reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + 5-alpha-cholest-7-en-3-beta-ol = NADPH + H+ + 5-alpha-cholesta-7,24-dien-3-beta-ol." [EC:1.3.1.72, MetaCyc:1.3.1.72-RXN]
synonym: "D24-sterol reductase activity" EXACT []
synonym: "lanosterol Delta(24)-reductase activity" NARROW [EC:1.3.1.72]
synonym: "lanosterol delta24-reductase activity" EXACT [EC:1.3.1.72]
synonym: "sterol:NADP+ delta24-oxidoreductase activity" EXACT [EC:1.3.1.72]
xref: EC:1.3.1.72
xref: MetaCyc:1.3.1.72-RXN
xref: Reactome:REACT_10122 "Reduction of desmosterol to cholesterol, Homo sapiens"
xref: Reactome:REACT_104881 "Reduction of desmosterol to cholesterol, Canis familiaris"
xref: Reactome:REACT_106601 "Reduction of desmosterol to cholesterol, Bos taurus"
xref: Reactome:REACT_108393 "Reduction of desmosterol to cholesterol, Gallus gallus"
xref: Reactome:REACT_108976 "Reduction of desmosterol to cholesterol, Oryza sativa"
xref: Reactome:REACT_109205 "Reduction of desmosterol to cholesterol, Danio rerio"
xref: Reactome:REACT_28290 "Reduction of desmosterol to cholesterol, Arabidopsis thaliana"
xref: Reactome:REACT_82239 "Reduction of desmosterol to cholesterol, Mus musculus"
xref: Reactome:REACT_84519 "Reduction of desmosterol to cholesterol, Taeniopygia guttata"
xref: Reactome:REACT_90195 "Reduction of desmosterol to cholesterol, Mycobacterium tuberculosis"
xref: Reactome:REACT_90692 "Reduction of desmosterol to cholesterol, Rattus norvegicus"
xref: Reactome:REACT_95246 "Reduction of desmosterol to cholesterol, Xenopus tropicalis"
xref: RHEA:13688
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050615
name: 1,2-dihydrovomilenine reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 17-O-acetylnorajmaline + NADP(+) = 1,2-dihydrovomilenine + H(+) + NADPH." [EC:1.3.1.73, RHEA:12323]
synonym: "17-O-acetylnorajmaline:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.73]
xref: EC:1.3.1.73
xref: KEGG:R05879
xref: MetaCyc:1.3.1.73-RXN
xref: RHEA:12323
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050616
name: secologanin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: loganin + NADPH + H+ + O2 = secologanin + NADP+ + 2 H2O." [EC:1.3.3.9, MetaCyc:1.3.3.9-RXN]
synonym: "loganin:oxygen oxidoreductase (ring-cleaving)" EXACT [EC:1.3.3.9]
xref: EC:1.3.3.9
xref: MetaCyc:1.3.3.9-RXN
xref: RHEA:20588
is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor

[Term]
id: GO:0050617
name: 15,16-dihydrobiliverdin:ferredoxin oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 15,16-dihydrobiliverdin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin." [EC:1.3.7.2, MetaCyc:1.3.7.2-RXN]
subset: gosubset_prok
synonym: "PebA" RELATED [EC:1.3.7.2]
xref: EC:1.3.7.2
xref: MetaCyc:1.3.7.2-RXN
is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0050618
name: phycoerythrobilin:ferredoxin oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3Z)-phycoerythrobilin + oxidized ferredoxin = 15,16-dihydrobiliverdin + reduced ferredoxin." [EC:1.3.7.3, MetaCyc:1.3.7.3-RXN]
subset: gosubset_prok
synonym: "(3Z)-phycoerythrobilin:ferredoxin oxidoreductase activity" EXACT [EC:1.3.7.3]
synonym: "PebB" RELATED [EC:1.3.7.3]
xref: EC:1.3.7.3
xref: MetaCyc:1.3.7.3-RXN
is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0050619
name: phytochromobilin:ferredoxin oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3Z)-phytochromobilin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin." [EC:1.3.7.4, MetaCyc:1.3.7.4-RXN]
synonym: "(3Z)-phytochromobilin:ferredoxin oxidoreductase activity" EXACT [EC:1.3.7.4]
synonym: "HY2" RELATED [EC:1.3.7.4]
synonym: "P-Phi-B synthase activity" RELATED [EC:1.3.7.4]
synonym: "PFB synthase activity" EXACT [EC:1.3.7.4]
synonym: "phytochromobilin synthase activity" EXACT [EC:1.3.7.4]
synonym: "PPhiB synthase activity" EXACT [EC:1.3.7.4]
xref: EC:1.3.7.4
xref: MetaCyc:1.3.7.4-RXN
is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0050620
name: phycocyanobilin:ferredoxin oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3Z)-phycocyanobilin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin." [EC:1.3.7.5, MetaCyc:1.3.7.5-RXN]
subset: gosubset_prok
synonym: "(3Z)-phycocyanobilin:ferredoxin oxidoreductase activity" EXACT [EC:1.3.7.5]
xref: EC:1.3.7.5
xref: MetaCyc:1.3.7.5-RXN
is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0050621
name: tryptophan alpha,beta-oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tryptophan + O(2) = alpha,beta-didehydrotryptophan + H(2)O(2) + H(+)." [EC:1.3.3.10, RHEA:19904]
comment: Note that this was EC:1.4.3.17.
synonym: "L-tryptophan 2',3'-oxidase activity" EXACT [EC:1.3.3.10]
synonym: "L-tryptophan alpha,beta-dehydrogenase activity" EXACT [EC:1.3.3.10]
synonym: "L-tryptophan:oxygen alpha,beta-oxidoreductase activity" EXACT [EC:1.3.3.10]
synonym: "tryptophan a,b-oxidase activity" EXACT []
xref: EC:1.3.3.10
xref: KEGG:R05317
xref: MetaCyc:1.4.3.17-RXN
xref: RHEA:19904
is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor

[Term]
id: GO:0050622
name: glycine dehydrogenase (cyanide-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: glycine + 2 A = HCN + CO2 + 2 AH2." [EC:1.4.99.5, MetaCyc:1.4.99.5-RXN]
synonym: "glycine:acceptor oxidoreductase (hydrogen-cyanide-forming)" EXACT [EC:1.4.99.5]
synonym: "HCN synthase activity" EXACT [EC:1.4.99.5]
synonym: "hydrogen cyanide synthase activity" EXACT [EC:1.4.99.5]
xref: EC:1.4.99.5
xref: MetaCyc:1.4.99.5-RXN
xref: RHEA:15824
is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors

[Term]
id: GO:0050623
name: berberine reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-canadine + 2 NADP(+) = berberine + H(+) + 2 NADPH." [EC:1.5.1.31, RHEA:21271]
synonym: "(R)-canadine synthase activity" EXACT [EC:1.5.1.31]
synonym: "(R)-tetrahydroberberine:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.31]
xref: EC:1.5.1.31
xref: KEGG:R07169
xref: MetaCyc:1.5.1.31-RXN
xref: RHEA:21271
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050624
name: vomilenine reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-dihydrovomilenine + NADP(+) = H(+) + NADPH + vomilenine." [EC:1.5.1.32, RHEA:16412]
synonym: "1,2-dihydrovomilenine:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.32]
xref: EC:1.5.1.32
xref: KEGG:R05878
xref: MetaCyc:1.5.1.32-RXN
xref: RHEA:16412
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050625
name: 2-hydroxy-1,4-benzoquinone reductase activity
namespace: molecular_function
alt_id: GO:0018540
def: "Catalysis of the reaction: 2-hydroxy-1,4-benzoquinone + 2 H(+) + NADH = benzene-1,2,4-triol + NAD(+)." [EC:1.6.5.7, RHEA:12431]
synonym: "1,2,4-trihydroxybenzene:NAD oxidoreductase activity" EXACT [EC:1.6.5.7]
synonym: "1,2,4-trihydroxybenzene:NAD+ oxidoreductase activity" EXACT [EC:1.6.5.7]
synonym: "2-hydroxy-1,4-benzoquinone:NADH oxidoreductase activity" EXACT [EC:1.6.5.7]
synonym: "hydroxybenzoquinone reductase activity" EXACT [EC:1.6.5.-]
synonym: "NADH:2-hydroxy-1,4-benzoquinone oxidoreductase activity" EXACT [EC:1.6.5.7]
xref: EC:1.6.5.7
xref: KEGG:R05399
xref: MetaCyc:1.6.5.7-RXN
xref: RHEA:12431
xref: UM-BBD_reactionID:r0667
is_a: GO:0016655 ! oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor

[Term]
id: GO:0050626
name: trimethylamine-N-oxide reductase (cytochrome c) activity
namespace: molecular_function
def: "Catalysis of the reaction: trimethylamine + 2 (ferricytochrome c)-subunit + H2O = trimethylamine-N-oxide + 2 (ferrocytochrome c)-subunit + 2 H+." [EC:1.7.2.3, MetaCyc:1.7.2.3-RXN]
subset: gosubset_prok
synonym: "TMAO reductase activity" EXACT [EC:1.7.2.3]
synonym: "TOR activity" EXACT [EC:1.7.2.3]
synonym: "trimethylamine:cytochrome c oxidoreductase activity" EXACT [EC:1.7.2.3]
xref: EC:1.7.2.3
xref: MetaCyc:1.7.2.3-RXN
xref: Wikipedia:Trimethylamine_N-oxide_reductase
is_a: GO:0016662 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor

[Term]
id: GO:0050627
name: mycothione reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(P)+ + mycothiol = NAD(P)H + H+ + mycothione." [EC:1.8.1.15, MetaCyc:1.8.1.15-RXN]
synonym: "mycothiol-disulfide reductase activity" EXACT [EC:1.8.1.15]
synonym: "mycothiol:NAD(P)+ oxidoreductase activity" EXACT [EC:1.8.1.15]
xref: EC:1.8.1.15
xref: MetaCyc:1.8.1.15-RXN
xref: Reactome:REACT_27243 "mycothione is reduced to mycothiol, Mycobacterium tuberculosis"
is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor

[Term]
id: GO:0050628
name: 2-oxopropyl-CoM reductase (carboxylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: acetoacetate + coenzyme M + NADP(+) = 2-oxopropyl-coenzyme M + CO(2) + NADPH." [EC:1.8.1.5, RHEA:16980]
subset: gosubset_prok
synonym: "2-KPCC activity" EXACT [EC:1.8.1.5]
synonym: "2-mercaptoethanesulfonate,acetoacetate:NADP+ oxidoreductase (decarboxylating)" EXACT [EC:1.8.1.5]
synonym: "NADPH:2-(2-ketopropylthio)ethanesulfonate oxidoreductase/carboxylase activity" EXACT [EC:1.8.1.5]
synonym: "NADPH:2-ketopropyl-coenzyme M oxidoreductase/carboxylase activity" EXACT [EC:1.8.1.5]
xref: EC:1.8.1.5
xref: KEGG:R05713
xref: MetaCyc:1.8.1.5-RXN
xref: RHEA:16980
xref: UM-BBD_reactionID:r0854
is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor

[Term]
id: GO:0050629
name: tetrachloroethene reductive dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: trichloroethene + chloride + acceptor = tetrachloroethene + reduced acceptor." [EC:1.97.1.8, MetaCyc:1.97.1.8-RXN]
subset: gosubset_prok
synonym: "acceptor:trichloroethene oxidoreductase (chlorinating)" EXACT [EC:1.97.1.8]
synonym: "tetrachloroethene reductase activity" EXACT [EC:1.97.1.8]
xref: EC:1.97.1.8
xref: MetaCyc:1.97.1.8-RXN
xref: RHEA:20356
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0050630
name: (iso)eugenol O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + isoeugenol = S-adenosyl-L-homocysteine + isomethyleugenol." [EC:2.1.1.146, MetaCyc:2.1.1.146-RXN]
synonym: "isoeugenol O-methyltransferase activity" EXACT []
synonym: "S-adenosyl-L-methionine:isoeugenol O-methyltransferase activity" EXACT [EC:2.1.1.146]
xref: EC:2.1.1.146
xref: MetaCyc:2.1.1.146-RXN
xref: RHEA:17084
is_a: GO:0008171 ! O-methyltransferase activity

[Term]
id: GO:0050631
name: corydaline synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 2 NADPH + palmatine = S-adenosyl-L-homocysteine + corydaline + 2 NADP(+)." [EC:2.1.1.147, RHEA:14776]
synonym: "S-adenosyl-L-methionine:protoberberine 13-C-methyltransferase activity" EXACT [EC:2.1.1.147]
xref: EC:2.1.1.147
xref: KEGG:R07241
xref: MetaCyc:2.1.1.147-RXN
xref: RHEA:14776
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0050632
name: propionyl-CoA C2-trimethyltridecanoyltransferase activity
namespace: molecular_function
alt_id: GO:0004770
def: "Catalysis of the reaction: 4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA = 3-oxopristanoyl-CoA + CoA." [EC:2.3.1.154, RHEA:10411]
synonym: "3-oxopristanoyl-CoA hydrolase activity" EXACT [EC:2.3.1.154]
synonym: "3-oxopristanoyl-CoA thiolase activity" EXACT [EC:2.3.1.154]
synonym: "4,8,12-trimethyltridecanoyl-CoA:propanoyl-CoA 2-C-4,8,12-trimethyltridecanoyltransferase activity" EXACT [EC:2.3.1.154]
synonym: "4,8,12-trimethyltridecanoyl-CoA:propanoyl-CoA C2-4,8,12-trimethyltridecanoyltransferase activity" EXACT [EC:2.3.1.154]
synonym: "oxopristanoyl-CoA thiolase activity" EXACT [EC:2.3.1.154]
synonym: "peroxisomal 3-oxoacyl coenzyme A thiolase" NARROW [EC:2.3.1.154]
synonym: "peroxisome sterol carrier protein thiolase" NARROW [EC:2.3.1.154]
synonym: "propionyl-CoA C(2)-trimethyltridecanoyltransferase activity" EXACT []
synonym: "SCPx" RELATED [EC:2.3.1.154]
synonym: "sterol carrier protein" RELATED [EC:2.3.1.154]
synonym: "sterol carrier protein X-related thiolase activity" RELATED []
xref: EC:2.3.1.154
xref: KEGG:R05330
xref: MetaCyc:2.3.1.154-RXN
xref: Reactome:REACT_100013 "3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA, Xenopus tropicalis"
xref: Reactome:REACT_10103 "Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA, Homo sapiens"
xref: Reactome:REACT_10113 "Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA, Homo sapiens"
xref: Reactome:REACT_103602 "Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA, Danio rerio"
xref: Reactome:REACT_104558 "Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA, Caenorhabditis elegans"
xref: Reactome:REACT_104587 "3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA, Mus musculus"
xref: Reactome:REACT_104943 "3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA, Danio rerio"
xref: Reactome:REACT_105102 "Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA, Danio rerio"
xref: Reactome:REACT_105774 "Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA, Mycobacterium tuberculosis"
xref: Reactome:REACT_106537 "Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA, Sus scrofa"
xref: Reactome:REACT_106600 "3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA, Sus scrofa"
xref: Reactome:REACT_107283 "3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA, Taeniopygia guttata"
xref: Reactome:REACT_107318 "Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA, Sus scrofa"
xref: Reactome:REACT_17019 "3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA, Homo sapiens"
xref: Reactome:REACT_30272 "Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA, Xenopus tropicalis"
xref: Reactome:REACT_30631 "Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA, Mus musculus"
xref: Reactome:REACT_30668 "Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA, Taeniopygia guttata"
xref: Reactome:REACT_34076 "Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA, Gallus gallus"
xref: Reactome:REACT_34110 "3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA, Bos taurus"
xref: Reactome:REACT_34164 "Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA, Caenorhabditis elegans"
xref: Reactome:REACT_77524 "Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA, Mus musculus"
xref: Reactome:REACT_78210 "Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA, Mycobacterium tuberculosis"
xref: Reactome:REACT_81392 "Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA, Xenopus tropicalis"
xref: Reactome:REACT_86720 "Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA, Gallus gallus"
xref: Reactome:REACT_87730 "Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA, Taeniopygia guttata"
xref: Reactome:REACT_87739 "3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA, Caenorhabditis elegans"
xref: Reactome:REACT_89127 "3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA, Gallus gallus"
xref: Reactome:REACT_94262 "Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA, Bos taurus"
xref: Reactome:REACT_95403 "3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA, Mycobacterium tuberculosis"
xref: Reactome:REACT_95599 "Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA, Bos taurus"
xref: RHEA:10411
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0050633
name: acetyl-CoA C-myristoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: myristoyl-CoA + acetyl-CoA = 3-oxopalmitoyl-CoA + CoA." [EC:2.3.1.155, MetaCyc:2.3.1.155-RXN]
synonym: "3-oxopalmitoyl-CoA hydrolase activity" EXACT [EC:2.3.1.155]
synonym: "3-oxopalmitoyl-CoA-CoA acetyltransferase activity" EXACT [EC:2.3.1.155]
synonym: "myristoyl-CoA C-acetyltransferase activity" EXACT [EC:2.3.1.155]
synonym: "myristoyl-CoA:acetyl-CoA C-myristoyltransferase activity" EXACT [EC:2.3.1.155]
xref: EC:2.3.1.155
xref: MetaCyc:2.3.1.155-RXN
xref: Reactome:REACT_100615 "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA, Caenorhabditis elegans"
xref: Reactome:REACT_101292 "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA, Gallus gallus"
xref: Reactome:REACT_101897 "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA, Drosophila melanogaster"
xref: Reactome:REACT_102432 "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA, Taeniopygia guttata"
xref: Reactome:REACT_102598 "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA, Bos taurus"
xref: Reactome:REACT_102613 "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA, Sus scrofa"
xref: Reactome:REACT_103468 "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA, Caenorhabditis elegans"
xref: Reactome:REACT_103773 "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA, Mus musculus"
xref: Reactome:REACT_105034 "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA, Drosophila melanogaster"
xref: Reactome:REACT_105300 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Sus scrofa"
xref: Reactome:REACT_106367 "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA, Gallus gallus"
xref: Reactome:REACT_107615 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Danio rerio"
xref: Reactome:REACT_108044 "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA, Xenopus tropicalis"
xref: Reactome:REACT_108311 "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA, Mus musculus"
xref: Reactome:REACT_108644 "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA, Danio rerio"
xref: Reactome:REACT_108748 "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA, Xenopus tropicalis"
xref: Reactome:REACT_110668 "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA, Mycobacterium tuberculosis"
xref: Reactome:REACT_110677 "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA, Mycobacterium tuberculosis"
xref: Reactome:REACT_1519 "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA, Homo sapiens"
xref: Reactome:REACT_1749 "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA, Homo sapiens"
xref: Reactome:REACT_2140 "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA, Homo sapiens"
xref: Reactome:REACT_2238 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Homo sapiens"
xref: Reactome:REACT_250 "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA, Homo sapiens"
xref: Reactome:REACT_28072 "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA, Danio rerio"
xref: Reactome:REACT_29655 "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA, Bos taurus"
xref: Reactome:REACT_29955 "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA, Rattus norvegicus"
xref: Reactome:REACT_30517 "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA, Mus musculus"
xref: Reactome:REACT_30775 "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA, Taeniopygia guttata"
xref: Reactome:REACT_30844 "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA, Rattus norvegicus"
xref: Reactome:REACT_31072 "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA, Gallus gallus"
xref: Reactome:REACT_31820 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Rattus norvegicus"
xref: Reactome:REACT_32141 "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA, Taeniopygia guttata"
xref: Reactome:REACT_32695 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Danio rerio"
xref: Reactome:REACT_33031 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Sus scrofa"
xref: Reactome:REACT_33661 "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA, Gallus gallus"
xref: Reactome:REACT_33795 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Taeniopygia guttata"
xref: Reactome:REACT_34330 "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA, Mus musculus"
xref: Reactome:REACT_34572 "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA, Mycobacterium tuberculosis"
xref: Reactome:REACT_35110 "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA, Bos taurus"
xref: Reactome:REACT_41977 "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA, Bos taurus"
xref: Reactome:REACT_440 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Homo sapiens"
xref: Reactome:REACT_481 "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA, Homo sapiens"
xref: Reactome:REACT_582 "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA, Homo sapiens"
xref: Reactome:REACT_63096 "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA, Bos taurus"
xref: Reactome:REACT_77376 "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA, Rattus norvegicus"
xref: Reactome:REACT_77914 "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA, Caenorhabditis elegans"
xref: Reactome:REACT_78011 "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA, Sus scrofa"
xref: Reactome:REACT_78418 "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA, Danio rerio"
xref: Reactome:REACT_79057 "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA, Caenorhabditis elegans"
xref: Reactome:REACT_79136 "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA, Xenopus tropicalis"
xref: Reactome:REACT_79288 "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA, Sus scrofa"
xref: Reactome:REACT_79870 "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA, Bos taurus"
xref: Reactome:REACT_80236 "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA, Danio rerio"
xref: Reactome:REACT_80706 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Rattus norvegicus"
xref: Reactome:REACT_80710 "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA, Drosophila melanogaster"
xref: Reactome:REACT_80921 "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA, Drosophila melanogaster"
xref: Reactome:REACT_81483 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Mus musculus"
xref: Reactome:REACT_81776 "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA, Mycobacterium tuberculosis"
xref: Reactome:REACT_83205 "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA, Rattus norvegicus"
xref: Reactome:REACT_83723 "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA, Rattus norvegicus"
xref: Reactome:REACT_85203 "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA, Mycobacterium tuberculosis"
xref: Reactome:REACT_85894 "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA, Gallus gallus"
xref: Reactome:REACT_86074 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Taeniopygia guttata"
xref: Reactome:REACT_86077 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Gallus gallus"
xref: Reactome:REACT_86330 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Mus musculus"
xref: Reactome:REACT_86642 "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA, Drosophila melanogaster"
xref: Reactome:REACT_87006 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Bos taurus"
xref: Reactome:REACT_87244 "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA, Danio rerio"
xref: Reactome:REACT_87671 "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA, Sus scrofa"
xref: Reactome:REACT_88762 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Mycobacterium tuberculosis"
xref: Reactome:REACT_89342 "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA, Caenorhabditis elegans"
xref: Reactome:REACT_89670 "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA, Rattus norvegicus"
xref: Reactome:REACT_90049 "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA, Xenopus tropicalis"
xref: Reactome:REACT_90542 "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA, Mus musculus"
xref: Reactome:REACT_90562 "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA, Caenorhabditis elegans"
xref: Reactome:REACT_92535 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Xenopus tropicalis"
xref: Reactome:REACT_92681 "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA, Gallus gallus"
xref: Reactome:REACT_93579 "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA, Taeniopygia guttata"
xref: Reactome:REACT_93856 "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA, Danio rerio"
xref: Reactome:REACT_94076 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Mycobacterium tuberculosis"
xref: Reactome:REACT_94352 "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA, Xenopus tropicalis"
xref: Reactome:REACT_94548 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Gallus gallus"
xref: Reactome:REACT_95378 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Xenopus tropicalis"
xref: Reactome:REACT_95654 "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA, Taeniopygia guttata"
xref: Reactome:REACT_96434 "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA, Mus musculus"
xref: Reactome:REACT_96695 "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA, Mycobacterium tuberculosis"
xref: Reactome:REACT_96710 "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA, Sus scrofa"
xref: Reactome:REACT_98620 "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA, Sus scrofa"
xref: Reactome:REACT_98737 "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA, Drosophila melanogaster"
xref: Reactome:REACT_99223 "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA, Taeniopygia guttata"
xref: Reactome:REACT_99499 "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA, Xenopus tropicalis"
xref: Reactome:REACT_99776 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Bos taurus"
xref: RHEA:18164
is_a: GO:0016408 ! C-acyltransferase activity
is_a: GO:0019107 ! myristoyltransferase activity

[Term]
id: GO:0050634
name: phloroisovalerophenone synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: isovaleryl-CoA + 3 malonyl-CoA = 4 CoASH + 3 CO2 + 3-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one." [EC:2.3.1.156, MetaCyc:2.3.1.156-RXN]
synonym: "3-methyl-1-(trihydroxyphenyl)butan-1-one synthase activity" EXACT [EC:2.3.1.156]
synonym: "isovaleryl-CoA:malonyl-CoA acyltransferase activity" EXACT [EC:2.3.1.156]
synonym: "valerophenone synthase activity" EXACT [EC:2.3.1.156]
xref: EC:2.3.1.156
xref: MetaCyc:2.3.1.156-RXN
xref: RHEA:23575
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0050635
name: acridone synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-methylanthranilyl-CoA + 3 H(+) + 3 malonyl-CoA = 1,3-dihydroxy-N-methylacridone + 3 CO(2) + 4 CoA + H(2)O." [EC:2.3.1.159, RHEA:22227]
synonym: "malonyl-CoA:N-methylanthraniloyl-CoA malonyltransferase (cyclizing)" EXACT [EC:2.3.1.159]
xref: EC:2.3.1.159
xref: KEGG:R07250
xref: MetaCyc:2.3.1.159-RXN
xref: RHEA:22227
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0050636
name: vinorine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 16-epivellosimine + acetyl-CoA = CoA + vinorine." [EC:2.3.1.160, RHEA:24019]
synonym: "acyl-CoA:16-epivellosimine O-acetyltransferase (cyclizing)" EXACT [EC:2.3.1.160]
xref: EC:2.3.1.160
xref: KEGG:R05876
xref: MetaCyc:2.3.1.160-RXN
xref: RHEA:24019
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0050637
name: lovastatin nonaketide synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + acetyl-CoA + 18 H(+) + 8 malonyl-CoA + 11 NADPH = S-adenosyl-L-homocysteine + 8 CO(2) + 9 CoA + dihydromonacolin L + 6 H(2)O + 11 NADP(+)." [EC:2.3.1.161, RHEA:18568]
synonym: "acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing, thioester-hydrolysing)" EXACT [EC:2.3.1.161]
xref: EC:2.3.1.161
xref: KEGG:R07251
xref: MetaCyc:2.3.1.161-RXN
xref: RHEA:18568
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0050638
name: taxadien-5-alpha-ol O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + taxa-4(20),11-dien-5alpha-ol = CoA + taxa-4(20),11-dien-5alpha-yl acetate." [EC:2.3.1.162, RHEA:22031]
synonym: "acetyl coenzyme A: taxa-4(20),11(12)-dien-5alpha-ol O-acetyl transferase activity" EXACT [EC:2.3.1.162]
synonym: "acetyl coenzyme A:taxa-4(20),11(12)-dien-5-alpha-ol O-acetyl transferase activity" EXACT [EC:2.3.1.162]
synonym: "acetyl-CoA:taxa-4(20),11-dien-5alpha-ol O-acetyltransferase activity" EXACT [EC:2.3.1.162]
synonym: "taxa-4(20),11(12)-dien-5alpha-ol-O-acetyltransferase activity" EXACT [EC:2.3.1.162]
synonym: "taxadien-5a-ol O-acetyltransferase activity" EXACT []
synonym: "taxadien-5alpha-ol O-acetyltransferase activity" EXACT [EC:2.3.1.162]
synonym: "taxadienol acetyltransferase activity" EXACT [EC:2.3.1.162]
xref: EC:2.3.1.162
xref: KEGG:R06307
xref: MetaCyc:2.3.1.162-RXN
xref: RHEA:22031
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0050639
name: 10-hydroxytaxane O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 10-desacetyltaxuyunnanin C + acetyl-CoA = CoA + taxuyunnanin C." [EC:2.3.1.163, RHEA:18840]
synonym: "acetyl coenzyme A: 10-hydroxytaxane O-acetyltransferase activity" EXACT [EC:2.3.1.163]
synonym: "acetyl coenzyme A:10-hydroxytaxane O-acetyltransferase activity" EXACT [EC:2.3.1.163]
synonym: "acetyl-CoA:taxan-10beta-ol O-acetyltransferase" BROAD [EC:2.3.1.163]
xref: EC:2.3.1.163
xref: KEGG:R07252
xref: MetaCyc:2.3.1.163-RXN
xref: RHEA:18840
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0050640
name: isopenicillin-N N-acyltransferase activity
namespace: molecular_function
alt_id: GO:0042319
alt_id: GO:0045440
def: "Catalysis of the reaction: phenylacetyl-CoA + isopenicillin N + H2O = CoA + penicillin G + L-2-aminohexanedioate." [EC:2.3.1.164, MetaCyc:2.3.1.164-RXN]
synonym: "acyl-CoA:isopenicillin N N-acyltransferase activity" EXACT [EC:2.3.1.164]
synonym: "acyl-coenzyme A:6-aminopenicillanic-acid-acyltransferase activity" EXACT [EC:2.3.1.164]
synonym: "acyl-coenzyme A:isopenicillin N acyltransferase activity" EXACT [EC:2.3.1.164]
synonym: "isopenicillin N:acyl-CoA acyltransferase activity" EXACT [EC:2.3.1.164]
synonym: "isopenicillin-N acyltransferase activity" EXACT []
xref: EC:2.3.1.164
xref: MetaCyc:2.3.1.164-RXN
xref: RHEA:20723
is_a: GO:0016410 ! N-acyltransferase activity

[Term]
id: GO:0050641
name: 6-methylsalicylic acid synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH = 6-methylsalicylate + 3 CO(2) + 4 CoA + H(2)O + NADP(+)." [EC:2.3.1.165, RHEA:12243]
synonym: "6-MSAS activity" EXACT [EC:2.3.1.165]
synonym: "acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl-reducing, thioester-hydrolysing and cyclizing)" EXACT [EC:2.3.1.165]
synonym: "MSAS activity" EXACT [EC:2.3.1.165]
xref: EC:2.3.1.165
xref: KEGG:R07253
xref: MetaCyc:2.3.1.165-RXN
xref: RHEA:12243
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0050642
name: 2-alpha-hydroxytaxane 2-O-benzoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 10-deacetyl-2-debenzoylbaccatin III + benzoyl-CoA = 10-deacetylbaccatin III + CoA." [EC:2.3.1.166, RHEA:18744]
synonym: "2-debenzoyl-7,13-diacetylbaccatin III-2-O-benzoyl transferase activity" EXACT [EC:2.3.1.166]
synonym: "2a-hydroxytaxane 2-O-benzoyltransferase activity" EXACT []
synonym: "2alpha-hydroxytaxane 2-O-benzoyltransferase activity" EXACT [EC:2.3.1.166]
synonym: "benzoyl-CoA:taxan-2alpha-ol O-benzoyltransferase activity" EXACT [EC:2.3.1.166]
synonym: "benzoyl-CoA:taxane 2-alpha-O-benzoyltransferase activity" EXACT [EC:2.3.1.166]
synonym: "benzoyl-CoA:taxane 2alpha-O-benzoyltransferase activity" EXACT [EC:2.3.1.166]
xref: EC:2.3.1.166
xref: KEGG:R06310
xref: MetaCyc:2.3.1.166-RXN
xref: RHEA:18744
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0050643
name: 10-deacetylbaccatin III 10-O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 10-deacetylbaccatin III + acetyl-CoA = baccatin III + CoA." [EC:2.3.1.167, RHEA:20140]
synonym: "acetyl-CoA:taxan-10beta-ol O-acetyltransferase" BROAD [EC:2.3.1.167]
xref: EC:2.3.1.167
xref: KEGG:R06311
xref: MetaCyc:2.3.1.167-RXN
xref: RHEA:20140
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0050644
name: cis-p-coumarate glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-4-coumarate + UDP-D-glucose = 4'-O-beta-D-glucosyl-cis-4-coumarate + H(+) + UDP." [EC:2.4.1.209, RHEA:13132]
synonym: "UDP-glucose:cis-p-coumarate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.209]
xref: EC:2.4.1.209
xref: KEGG:R05324
xref: MetaCyc:2.4.1.209-RXN
xref: RHEA:13132
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0050645
name: limonoid glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + limonin = glucosyl-limonin + UDP." [EC:2.4.1.210]
synonym: "LGTase activity" EXACT [EC:2.4.1.210]
synonym: "limonoid UDP-glucosyltransferase activity" EXACT [EC:2.4.1.210]
synonym: "uridine diphosphoglucose-limonoid glucosyltransferase activity" EXACT [EC:2.4.1.210]
xref: EC:2.4.1.210
xref: MetaCyc:2.4.1.210-RXN
xref: RHEA:11259
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0050646
name: 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds." [GOC:ai]
synonym: "5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid binding" EXACT []
is_a: GO:0036041 ! long-chain fatty acid binding

[Term]
id: GO:0050647
name: 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds." [GOC:ai]
synonym: "5-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid binding" EXACT []
is_a: GO:0036041 ! long-chain fatty acid binding
is_a: GO:0050542 ! icosanoid binding

[Term]
id: GO:0050648
name: 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds." [GOC:ai]
synonym: "5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid binding" EXACT []
is_a: GO:0036041 ! long-chain fatty acid binding
is_a: GO:0050542 ! icosanoid binding

[Term]
id: GO:0050649
name: testosterone 6-beta-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: testosterone + donor-H2 + O2 = 6-beta-hydroxytestosterone + H2O." [GOC:ai, PMID:11726664]
synonym: "testosterone 6b-hydroxylase activity" EXACT []
is_a: GO:0008395 ! steroid hydroxylase activity

[Term]
id: GO:0050650
name: chondroitin sulfate proteoglycan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:ai]
subset: gosubset_prok
synonym: "chondroitin sulfate proteoglycan anabolism" EXACT []
synonym: "chondroitin sulfate proteoglycan biosynthesis" EXACT []
synonym: "chondroitin sulfate proteoglycan formation" EXACT []
synonym: "chondroitin sulfate proteoglycan synthesis" EXACT []
synonym: "chondroitin sulphate proteoglycan biosynthesis" EXACT []
synonym: "chondroitin sulphate proteoglycan biosynthetic process" EXACT []
is_a: GO:0006024 ! glycosaminoglycan biosynthetic process
is_a: GO:0030166 ! proteoglycan biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:0050654 ! chondroitin sulfate proteoglycan metabolic process

[Term]
id: GO:0050651
name: dermatan sulfate proteoglycan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dermatan sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are dermatan sulfate (chondroitin sulfate B). Dermatan sulfate is a glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units." [GOC:ai]
subset: gosubset_prok
synonym: "chondroitin sulfate B proteoglycan biosynthesis" EXACT []
synonym: "chondroitin sulfate B proteoglycan biosynthetic process" EXACT []
synonym: "dermatan sulfate proteoglycan anabolism" EXACT []
synonym: "dermatan sulfate proteoglycan biosynthesis" EXACT []
synonym: "dermatan sulfate proteoglycan formation" EXACT []
synonym: "dermatan sulfate proteoglycan synthesis" EXACT []
synonym: "dermatan sulphate proteoglycan biosynthesis" EXACT []
synonym: "dermatan sulphate proteoglycan biosynthetic process" EXACT []
is_a: GO:0030166 ! proteoglycan biosynthetic process
is_a: GO:0050655 ! dermatan sulfate proteoglycan metabolic process

[Term]
id: GO:0050652
name: dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
namespace: biological_process
def: "The elongation of dermatan sulfate proteoglycan chains by alternate addition of N-acetylhexosamine and GlcUA residues to the GAG-protein linkage region tetrasaccharide of dermatan sulfate." [GOC:ai, PMID:11788602]
subset: gosubset_prok
synonym: "chondroitin sulfate B proteoglycan biosynthesis, polysaccharide chain biosynthesis" EXACT []
synonym: "chondroitin sulfate B proteoglycan biosynthesis, polysaccharide chain biosynthetic process" EXACT []
synonym: "chondroitin sulfate B proteoglycan chain elongation" EXACT []
synonym: "dermatan sulfate proteoglycan anabolism, polysaccharide chain anabolism" EXACT []
synonym: "dermatan sulfate proteoglycan chain elongation" EXACT []
synonym: "dermatan sulfate proteoglycan formation, polysaccharide chain biosynthesis" EXACT []
synonym: "dermatan sulfate proteoglycan formation, polysaccharide chain formation" EXACT []
synonym: "dermatan sulfate proteoglycan synthesis, polysaccharide chain synthesis" EXACT []
synonym: "dermatan sulphate proteoglycan biosynthesis, polysaccharide chain biosynthesis" EXACT []
synonym: "dermatan sulphate proteoglycan biosynthesis, polysaccharide chain biosynthetic process" EXACT []
is_a: GO:0033692 ! cellular polysaccharide biosynthetic process
relationship: part_of GO:0050651 ! dermatan sulfate proteoglycan biosynthetic process

[Term]
id: GO:0050653
name: chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
namespace: biological_process
def: "The elongation of chondroitin sulfate proteoglycan chains by alternate addition of N-acetylhexosamine and GlcUA residues to the GAG-protein linkage region tetrasaccharide of chondroitin sulfate." [GOC:ai, PMID:11788602]
subset: gosubset_prok
synonym: "chondroitin sulfate proteoglycan anabolism, polysaccharide chain anabolism" EXACT []
synonym: "chondroitin sulfate proteoglycan chain elongation" EXACT []
synonym: "chondroitin sulfate proteoglycan formation, polysaccharide chain biosynthesis" EXACT []
synonym: "chondroitin sulfate proteoglycan formation, polysaccharide chain formation" EXACT []
synonym: "chondroitin sulfate proteoglycan synthesis, polysaccharide chain synthesis" EXACT []
synonym: "chondroitin sulphate proteoglycan biosynthesis, polysaccharide chain biosynthesis" EXACT []
synonym: "chondroitin sulphate proteoglycan biosynthesis, polysaccharide chain biosynthetic process" EXACT []
is_a: GO:0033692 ! cellular polysaccharide biosynthetic process
relationship: part_of GO:0050650 ! chondroitin sulfate proteoglycan biosynthetic process

[Term]
id: GO:0050654
name: chondroitin sulfate proteoglycan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:ai]
subset: gosubset_prok
synonym: "chondroitin sulfate proteoglycan metabolism" EXACT []
synonym: "chondroitin sulphate proteoglycan metabolic process" EXACT []
synonym: "chondroitin sulphate proteoglycan metabolism" EXACT []
is_a: GO:0006029 ! proteoglycan metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0030203 ! glycosaminoglycan metabolic process
is_a: GO:0043436 ! oxoacid metabolic process

[Term]
id: GO:0050655
name: dermatan sulfate proteoglycan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dermatan sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are dermatan sulfate (chondroitin sulfate B). Dermatan sulfate is a glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units." [GOC:ai]
subset: gosubset_prok
synonym: "chondroitin sulfate B proteoglycan metabolic process" EXACT []
synonym: "chondroitin sulfate B proteoglycan metabolism" EXACT []
synonym: "dermatan sulfate proteoglycan metabolism" EXACT []
synonym: "dermatan sulphate proteoglycan metabolic process" EXACT []
synonym: "dermatan sulphate proteoglycan metabolism" EXACT []
is_a: GO:0006029 ! proteoglycan metabolic process

[Term]
id: GO:0050656
name: 3'-phosphoadenosine 5'-phosphosulfate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with 3'-phosphoadenosine 5'-phosphosulfate (PAPS), a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems." [GOC:ai]
synonym: "3'-phosphoadenosine 5'-phosphosulphate binding" EXACT []
synonym: "3'-phosphoadenylyl-sulfate binding" EXACT []
synonym: "adenosine 3'-phosphate 5'-phosphosulfate binding" EXACT []
synonym: "PAPS binding" EXACT []
synonym: "phosphoadenosine phosphosulfate binding" EXACT []
is_a: GO:0032550 ! purine ribonucleoside binding
is_a: GO:0032559 ! adenyl ribonucleotide binding
is_a: GO:0043168 ! anion binding
is_a: GO:1901681 ! sulfur compound binding

[Term]
id: GO:0050657
name: nucleic acid transport
namespace: biological_process
def: "The directed movement of nucleic acids, single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0015931 ! nucleobase-containing compound transport

[Term]
id: GO:0050658
name: RNA transport
namespace: biological_process
def: "The directed movement of RNA, ribonucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0050657 ! nucleic acid transport
is_a: GO:0051236 ! establishment of RNA localization

[Term]
id: GO:0050659
name: N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reactions: 3'-phosphoadenylyl sulfate + dermatan = adenosine 3',5'-bisphosphate + dermatan 6'-sulfate and 3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate." [EC:2.8.2.33]
comment: Consider instead annotating to the individual reactions: 'chondroitin 6-sulfotransferase activity ; GO:0008459' and 'dermatan 6-sulfotransferase activity ; GO:0036443'.
synonym: "3'-phosphoadenylyl-sulfate:dermatan 6'-sulfotransferase activity" EXACT [EC:2.8.2.33]
synonym: "GalNAc4S-6ST" RELATED [EC:2.8.2.33]
synonym: "N-acetylgalactosamine 4-sulfate 6-O-sulphotransferase activity" EXACT [EC:2.8.2.33]
xref: EC:2.8.2.33
xref: KEGG:R02181
xref: KEGG:R07288
xref: MetaCyc:RXN-7953
xref: MetaCyc:RXN-7954
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0050660
name: flavin adenine dinucleotide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
subset: gosubset_prok
synonym: "FAD or FADH2 binding" EXACT []
synonym: "flavine-adenine dinucleotide binding" EXACT []
is_a: GO:0000166 ! nucleotide binding
is_a: GO:0043168 ! anion binding
is_a: GO:0050662 ! coenzyme binding

[Term]
id: GO:0050661
name: NADP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai]
synonym: "NADP or NADPH binding" RELATED [GOC:mah]
synonym: "NADP+ or NADPH binding" RELATED []
synonym: "nicotinamide adenine dinucleotide phosphate binding" EXACT []
is_a: GO:0000166 ! nucleotide binding
is_a: GO:0050662 ! coenzyme binding

[Term]
id: GO:0050662
name: coenzyme binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0048037 ! cofactor binding

[Term]
id: GO:0050663
name: cytokine secretion
namespace: biological_process
def: "The regulated release of cytokines from a cell. Cytokines are any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity." [GOC:ai, GOC:bf, ISBN:0198599471]
synonym: "interferon secretion" NARROW [GOC:add, GOC:mah]
synonym: "interleukin secretion" NARROW [GOC:add, GOC:mah]
is_a: GO:0009306 ! protein secretion
relationship: part_of GO:0001816 ! cytokine production

[Term]
id: GO:0050664
name: oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule." [EC:1.6.3.-]
synonym: "oxidoreductase activity, acting on NADH or NADPH, oxygen as acceptor" RELATED []
xref: EC:1.6.3
is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H

[Term]
id: GO:0050665
name: hydrogen peroxide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA." [GOC:ai]
subset: gosubset_prok
synonym: "H2O2 biosynthetic process" EXACT [GOC:mah]
synonym: "hydrogen peroxide anabolism" EXACT []
synonym: "hydrogen peroxide biosynthesis" EXACT []
synonym: "hydrogen peroxide formation" EXACT []
synonym: "hydrogen peroxide generation" EXACT []
synonym: "hydrogen peroxide synthesis" EXACT []
is_a: GO:0042743 ! hydrogen peroxide metabolic process
is_a: GO:0044249 ! cellular biosynthetic process
is_a: GO:1903409 ! reactive oxygen species biosynthetic process

[Term]
id: GO:0050666
name: regulation of homocysteine metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid." [GOC:ai]
subset: gosubset_prok
synonym: "regulation of Hcy metabolic process" EXACT []
synonym: "regulation of Hcy metabolism" EXACT []
synonym: "regulation of homocysteine metabolism" EXACT []
is_a: GO:0031335 ! regulation of sulfur amino acid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050667 ! homocysteine metabolic process
relationship: regulates GO:0050667 ! homocysteine metabolic process

[Term]
id: GO:0050667
name: homocysteine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. Homocysteine is an important intermediate in the metabolic reactions of its S-methyl derivative, methionine." [ISBN:0198506732]
subset: gosubset_prok
synonym: "Hcy metabolic process" EXACT []
synonym: "Hcy metabolism" EXACT []
synonym: "homocysteine metabolism" EXACT []
is_a: GO:0000096 ! sulfur amino acid metabolic process
is_a: GO:0006575 ! cellular modified amino acid metabolic process
is_a: GO:1901605 ! alpha-amino acid metabolic process

[Term]
id: GO:0050668
name: positive regulation of homocysteine metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving homocysteine." [GOC:ai]
subset: gosubset_prok
synonym: "activation of homocysteine metabolic process" NARROW []
synonym: "positive regulation of Hcy metabolic process" EXACT []
synonym: "positive regulation of Hcy metabolism" EXACT []
synonym: "positive regulation of homocysteine metabolism" EXACT []
synonym: "stimulation of homocysteine metabolic process" NARROW []
synonym: "up regulation of homocysteine metabolic process" EXACT []
synonym: "up-regulation of homocysteine metabolic process" EXACT []
synonym: "upregulation of homocysteine metabolic process" EXACT []
is_a: GO:0031337 ! positive regulation of sulfur amino acid metabolic process
is_a: GO:0050666 ! regulation of homocysteine metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0050667 ! homocysteine metabolic process
relationship: positively_regulates GO:0050667 ! homocysteine metabolic process

[Term]
id: GO:0050669
name: negative regulation of homocysteine metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving homocysteine." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of homocysteine metabolic process" EXACT []
synonym: "down-regulation of homocysteine metabolic process" EXACT []
synonym: "downregulation of homocysteine metabolic process" EXACT []
synonym: "inhibition of homocysteine metabolic process" NARROW []
synonym: "negative regulation of Hcy metabolic process" EXACT []
synonym: "negative regulation of Hcy metabolism" EXACT []
synonym: "negative regulation of homocysteine metabolism" EXACT []
is_a: GO:0031336 ! negative regulation of sulfur amino acid metabolic process
is_a: GO:0050666 ! regulation of homocysteine metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0050667 ! homocysteine metabolic process
relationship: negatively_regulates GO:0050667 ! homocysteine metabolic process

[Term]
id: GO:0050670
name: regulation of lymphocyte proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lymphocyte proliferation." [GOC:ai]
is_a: GO:0032944 ! regulation of mononuclear cell proliferation
is_a: GO:0051249 ! regulation of lymphocyte activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0046651 ! lymphocyte proliferation
relationship: regulates GO:0046651 ! lymphocyte proliferation

[Term]
id: GO:0050671
name: positive regulation of lymphocyte proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of lymphocyte proliferation." [GOC:ai]
synonym: "activation of lymphocyte proliferation" NARROW []
synonym: "stimulation of lymphocyte proliferation" NARROW []
synonym: "up regulation of lymphocyte proliferation" EXACT []
synonym: "up-regulation of lymphocyte proliferation" EXACT []
synonym: "upregulation of lymphocyte proliferation" EXACT []
is_a: GO:0032946 ! positive regulation of mononuclear cell proliferation
is_a: GO:0050670 ! regulation of lymphocyte proliferation
is_a: GO:0051251 ! positive regulation of lymphocyte activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0046651 ! lymphocyte proliferation
relationship: positively_regulates GO:0046651 ! lymphocyte proliferation

[Term]
id: GO:0050672
name: negative regulation of lymphocyte proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of lymphocyte proliferation." [GOC:ai]
synonym: "down regulation of lymphocyte proliferation" EXACT []
synonym: "down-regulation of lymphocyte proliferation" EXACT []
synonym: "downregulation of lymphocyte proliferation" EXACT []
synonym: "inhibition of lymphocyte proliferation" NARROW []
is_a: GO:0032945 ! negative regulation of mononuclear cell proliferation
is_a: GO:0050670 ! regulation of lymphocyte proliferation
is_a: GO:0051250 ! negative regulation of lymphocyte activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0046651 ! lymphocyte proliferation
relationship: negatively_regulates GO:0046651 ! lymphocyte proliferation

[Term]
id: GO:0050673
name: epithelial cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances." [ISBN:0721662544]
is_a: GO:0008283 ! cell proliferation

[Term]
id: GO:0050674
name: urothelial cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of urothelial cells, resulting in the expansion of a cell population. Urothelial cells make up a layer of transitional epithelium in the wall of the bladder, ureter, and renal pelvis, external to the lamina propria." [ISBN:0721662544]
is_a: GO:0050673 ! epithelial cell proliferation

[Term]
id: GO:0050675
name: regulation of urothelial cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of urothelial cell proliferation." [GOC:ai]
is_a: GO:0050678 ! regulation of epithelial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050674 ! urothelial cell proliferation
relationship: regulates GO:0050674 ! urothelial cell proliferation

[Term]
id: GO:0050676
name: negative regulation of urothelial cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of urothelial cell proliferation." [GOC:ai]
synonym: "down regulation of urothelial cell proliferation" EXACT []
synonym: "down-regulation of urothelial cell proliferation" EXACT []
synonym: "downregulation of urothelial cell proliferation" EXACT []
synonym: "inhibition of urothelial cell proliferation" NARROW []
is_a: GO:0050675 ! regulation of urothelial cell proliferation
is_a: GO:0050680 ! negative regulation of epithelial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0050674 ! urothelial cell proliferation
relationship: negatively_regulates GO:0050674 ! urothelial cell proliferation

[Term]
id: GO:0050677
name: positive regulation of urothelial cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of urothelial cell proliferation." [GOC:ai]
synonym: "activation of urothelial cell proliferation" NARROW []
synonym: "stimulation of urothelial cell proliferation" NARROW []
synonym: "up regulation of urothelial cell proliferation" EXACT []
synonym: "up-regulation of urothelial cell proliferation" EXACT []
synonym: "upregulation of urothelial cell proliferation" EXACT []
is_a: GO:0050675 ! regulation of urothelial cell proliferation
is_a: GO:0050679 ! positive regulation of epithelial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0050674 ! urothelial cell proliferation
relationship: positively_regulates GO:0050674 ! urothelial cell proliferation

[Term]
id: GO:0050678
name: regulation of epithelial cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of epithelial cell proliferation." [GOC:ai]
is_a: GO:0042127 ! regulation of cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050673 ! epithelial cell proliferation
relationship: regulates GO:0050673 ! epithelial cell proliferation

[Term]
id: GO:0050679
name: positive regulation of epithelial cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of epithelial cell proliferation." [GOC:ai]
synonym: "activation of epithelial cell proliferation" NARROW []
synonym: "stimulation of epithelial cell proliferation" NARROW []
synonym: "up regulation of epithelial cell proliferation" EXACT []
synonym: "up-regulation of epithelial cell proliferation" EXACT []
synonym: "upregulation of epithelial cell proliferation" EXACT []
is_a: GO:0008284 ! positive regulation of cell proliferation
is_a: GO:0050678 ! regulation of epithelial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0050673 ! epithelial cell proliferation
relationship: positively_regulates GO:0050673 ! epithelial cell proliferation

[Term]
id: GO:0050680
name: negative regulation of epithelial cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation." [GOC:ai]
synonym: "down regulation of epithelial cell proliferation" EXACT []
synonym: "down-regulation of epithelial cell proliferation" EXACT []
synonym: "downregulation of epithelial cell proliferation" EXACT []
synonym: "inhibition of epithelial cell proliferation" NARROW []
is_a: GO:0008285 ! negative regulation of cell proliferation
is_a: GO:0050678 ! regulation of epithelial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0050673 ! epithelial cell proliferation
relationship: negatively_regulates GO:0050673 ! epithelial cell proliferation

[Term]
id: GO:0050681
name: androgen receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an androgen receptor." [GOC:ai]
synonym: "AR binding" EXACT []
is_a: GO:0035258 ! steroid hormone receptor binding

[Term]
id: GO:0050682
name: AF-2 domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the AF-2 domain of a protein, a highly conserved ligand-dependent transactivation domain which is essential for receptor-mediated transcriptional activation." [PMID:9682036]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0050683
name: AF-1 domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the AF-1 domain of a protein, a ligand-independent transactivation domain which is required for the full transcriptional activity of the receptor." [PMID:9682036]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0050684
name: regulation of mRNA processing
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide." [GOC:ai]
subset: gosubset_prok
is_a: GO:0010468 ! regulation of gene expression
is_a: GO:1903311 ! regulation of mRNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006397 ! mRNA processing
relationship: regulates GO:0006397 ! mRNA processing

[Term]
id: GO:0050685
name: positive regulation of mRNA processing
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mRNA processing." [GOC:ai]
subset: gosubset_prok
synonym: "activation of mRNA processing" NARROW []
synonym: "stimulation of mRNA processing" NARROW []
synonym: "up regulation of mRNA processing" EXACT []
synonym: "up-regulation of mRNA processing" EXACT []
synonym: "upregulation of mRNA processing" EXACT []
is_a: GO:0010628 ! positive regulation of gene expression
is_a: GO:0050684 ! regulation of mRNA processing
is_a: GO:1903313 ! positive regulation of mRNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006397 ! mRNA processing
relationship: positively_regulates GO:0006397 ! mRNA processing

[Term]
id: GO:0050686
name: negative regulation of mRNA processing
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mRNA processing." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of mRNA processing" EXACT []
synonym: "down-regulation of mRNA processing" EXACT []
synonym: "downregulation of mRNA processing" EXACT []
synonym: "inhibition of mRNA processing" NARROW []
is_a: GO:0010629 ! negative regulation of gene expression
is_a: GO:0050684 ! regulation of mRNA processing
is_a: GO:1903312 ! negative regulation of mRNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006397 ! mRNA processing
relationship: negatively_regulates GO:0006397 ! mRNA processing

[Term]
id: GO:0050687
name: negative regulation of defense response to virus
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of antiviral mechanisms, thereby facilitating viral replication." [GOC:ai]
synonym: "down regulation of antiviral response" EXACT []
synonym: "down-regulation of antiviral response" EXACT []
synonym: "downregulation of antiviral response" EXACT []
synonym: "inhibition of antiviral response" NARROW []
synonym: "negative regulation of antiviral response" EXACT [GOC:dph]
is_a: GO:0002698 ! negative regulation of immune effector process
is_a: GO:0002832 ! negative regulation of response to biotic stimulus
is_a: GO:0031348 ! negative regulation of defense response
is_a: GO:0032102 ! negative regulation of response to external stimulus
is_a: GO:0043901 ! negative regulation of multi-organism process
is_a: GO:0050688 ! regulation of defense response to virus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051607 ! defense response to virus
relationship: negatively_regulates GO:0051607 ! defense response to virus

[Term]
id: GO:0050688
name: regulation of defense response to virus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the antiviral response of a cell or organism." [GOC:ai]
synonym: "regulation of antiviral response" EXACT []
is_a: GO:0002697 ! regulation of immune effector process
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0032101 ! regulation of response to external stimulus
is_a: GO:0043900 ! regulation of multi-organism process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051607 ! defense response to virus
relationship: regulates GO:0051607 ! defense response to virus

[Term]
id: GO:0050689
name: negative regulation of defense response to virus by host
namespace: biological_process
def: "Any host process that results in the inhibition of antiviral immune response mechanisms, thereby facilitating viral replication. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:ai, GOC:dph, GOC:tb]
synonym: "down regulation of antiviral response by host" EXACT []
synonym: "down-regulation of antiviral response by host" EXACT []
synonym: "downregulation of antiviral response by host" EXACT []
synonym: "inhibition of antiviral response by host" NARROW []
synonym: "negative regulation by host of antiviral response" EXACT []
synonym: "negative regulation of antiviral response by host" EXACT [GOC:dph, GOC:tb]
is_a: GO:0050687 ! negative regulation of defense response to virus
is_a: GO:0050691 ! regulation of defense response to virus by host

[Term]
id: GO:0050690
name: regulation of defense response to virus by virus
namespace: biological_process
def: "Any viral process that modulates the frequency, rate, or extent of the antiviral response of the host cell or organism." [GOC:ai, GOC:dph]
synonym: "regulation by virus of antiviral response" EXACT []
synonym: "regulation of antiviral response by virus" EXACT [GOC:dph]
synonym: "viral regulation of antiviral response" EXACT []
xref: Reactome:REACT_11068 "Nef and signal transduction, Homo sapiens"
xref: Reactome:REACT_11103 "Nef mediated downregulation of MHC class I complex cell surface expression, Homo sapiens"
xref: Reactome:REACT_11139 "Nef mediated downregulation of CD28 cell surface expression, Homo sapiens"
xref: Reactome:REACT_11149 "Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters, Homo sapiens"
xref: Reactome:REACT_11166 "Nef Mediated CD4 Down-regulation, Homo sapiens"
xref: Reactome:REACT_11200 "Nef Mediated CD8 Down-regulation, Homo sapiens"
xref: Reactome:REACT_11221 "Nef mediated activation of the T-cell receptor, Homo sapiens"
is_a: GO:0050688 ! regulation of defense response to virus

[Term]
id: GO:0050691
name: regulation of defense response to virus by host
namespace: biological_process
def: "Any host process that modulates the frequency, rate, or extent of the antiviral response of a host cell or organism." [GOC:ai, GOC:dph]
synonym: "host regulation of antiviral response" EXACT []
synonym: "regulation by host of antiviral response" EXACT []
synonym: "regulation of antiviral response by host" RELATED [GOC:dph]
is_a: GO:0050688 ! regulation of defense response to virus

[Term]
id: GO:0050692
name: DBD domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the DBD, DNA binding domain, of a protein. The DNA binding domain of the vitamin D receptor, one of a family of receptors with the DBD, is split into three regions, the P, D and T boxes. Residues that are critical for target sequence selectivity form the P-box. The D-box contains residues that are important for homodimerization of class I nuclear receptors. The T-box is essential for both DNA-binding and transactivation of the VDR; this region may also be important for dimerization with RXR for class II nuclear receptors." [PMID:9682036]
synonym: "DNA binding domain binding" EXACT []
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0050693
name: LBD domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the LBD, the ligand binding domain found in nuclear receptors. In general, the LBDs consist of three layers comprised of twelve alpha-helices and several beta-strands that are organized around a lipophilic ligand-binding pocket." [PMID:9682036]
synonym: "ligand binding domain binding" EXACT []
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0050694
name: galactose 3-O-sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyllactosamine + 3'-phosphoadenosine 5'-phosphosulfate = 3-sulfo-N-acetyllactosamine + adenosine 3',5'-bisphosphate. N-acetyllactosamine residues are found in a number of different carbohydrate types. N-acetyllactosamine can also be written as Gal-beta-(1,4)-GlcNAc." [GOC:ai, PMID:11323440, PMID:11356829]
synonym: "Gal-3-O-sulfotransferase activity" EXACT []
synonym: "galactose 3-O-sulphotransferase activity" EXACT []
xref: EC:2.8.2.-
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0050695
name: benzoylformate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzoylformate = benzaldehyde + CO2." [EC:4.1.1.7, MetaCyc:BENZOYLFORMATE-DECARBOXYLASE-RXN]
subset: gosubset_prok
synonym: "benzoylformate carboxy-lyase (benzaldehyde-forming)" EXACT [EC:4.1.1.7]
synonym: "benzoylformate carboxy-lyase activity" EXACT [EC:4.1.1.7]
synonym: "phenylglyoxylate decarboxylase activity" EXACT []
xref: EC:4.1.1.7
xref: MetaCyc:BENZOYLFORMATE-DECARBOXYLASE-RXN
xref: RHEA:23371
xref: UM-BBD_reactionID:r1049
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050696
name: trichloroethylene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of trichloroethylene, a toxic, colorless, photoreactive, chlorinated hydrocarbon liquid, commonly used as a metal degreaser and solvent." [GOC:ai]
subset: gosubset_prok
synonym: "trichloroethene catabolic process" EXACT []
synonym: "trichloroethene catabolism" EXACT []
synonym: "trichloroethylene breakdown" EXACT []
synonym: "trichloroethylene catabolism" EXACT []
synonym: "trichloroethylene degradation" EXACT []
is_a: GO:0018979 ! trichloroethylene metabolic process
is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process

[Term]
id: GO:0050697
name: 1,1,2-trichloroethene reductive dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: trichloroethene + 2 H+ + 2 e- = HCl + 1,2-dichloroethene." [MetaCyc:TCEREDCHLOR-RXN, UM-BBD_enzymeID:e0271]
synonym: "1,1,2-trichloroethylene reductive dehalogenase activity" EXACT []
synonym: "TCE-reductive dehalogenase activity" EXACT []
xref: MetaCyc:TCEREDCHLOR-RXN
xref: UM-BBD_enzymeID:e0271
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0050698
name: proteoglycan sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + proteoglycan = adenosine 3',5'-bisphosphate + proteoglycan sulfate. A proteoglycan is a glycoprotein whose carbohydrate units are glycosaminoglycans." [EC:2.8.2.-, GOC:ai]
synonym: "proteoglycan sulfate transfer" RELATED []
synonym: "proteoglycan sulphotransferase activity" EXACT []
xref: EC:2.8.2.-
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0050699
name: WW domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions." [PMID:14531730]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0050700
name: CARD domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a CARD (N-terminal caspase recruitment) domain, a protein-protein interaction domain that belongs to the death domain-fold superfamily. These protein molecule families are similar in structure with each consisting of six or seven anti-parallel alpha-helices that form highly specific homophilic interactions between signaling partners. CARD exists in the N-terminal prodomains of several caspases and in apoptosis-regulatory proteins and mediates the assembly of CARD-containing proteins that participate in activation or suppression of CARD carrying members of the caspase family." [PMID:12054670]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0050701
name: interleukin-1 secretion
namespace: biological_process
def: "The regulated release of interleukin-1 from a cell. Interleukin 1 is produced mainly by activated macrophages; it stimulates thymocyte proliferation by inducing interleukin 2 release and it is involved in the inflammatory response." [GOC:ai, ISBN:0198506732]
synonym: "IL-1 secretion" EXACT []
is_a: GO:0050663 ! cytokine secretion
relationship: part_of GO:0032612 ! interleukin-1 production

[Term]
id: GO:0050702
name: interleukin-1 beta secretion
namespace: biological_process
def: "The regulated release of interleukin 1 beta from a cell." [GOC:ai]
synonym: "IL-1b secretion" EXACT []
is_a: GO:0050701 ! interleukin-1 secretion
relationship: part_of GO:0032611 ! interleukin-1 beta production

[Term]
id: GO:0050703
name: interleukin-1 alpha secretion
namespace: biological_process
def: "The regulated release of interleukin-1 alpha from a cell." [GOC:ai]
synonym: "IL-1a secretion" EXACT []
is_a: GO:0050701 ! interleukin-1 secretion
relationship: part_of GO:0032610 ! interleukin-1 alpha production

[Term]
id: GO:0050704
name: regulation of interleukin-1 secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of interleukin-1 from a cell." [GOC:ai]
is_a: GO:0032652 ! regulation of interleukin-1 production
is_a: GO:0050707 ! regulation of cytokine secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050701 ! interleukin-1 secretion
relationship: regulates GO:0050701 ! interleukin-1 secretion

[Term]
id: GO:0050705
name: regulation of interleukin-1 alpha secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of interleukin-1 alpha from a cell." [GOC:ai]
is_a: GO:0032650 ! regulation of interleukin-1 alpha production
is_a: GO:0050704 ! regulation of interleukin-1 secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050703 ! interleukin-1 alpha secretion
relationship: regulates GO:0050703 ! interleukin-1 alpha secretion

[Term]
id: GO:0050706
name: regulation of interleukin-1 beta secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell." [GOC:ai]
is_a: GO:0032651 ! regulation of interleukin-1 beta production
is_a: GO:0050704 ! regulation of interleukin-1 secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050702 ! interleukin-1 beta secretion
relationship: regulates GO:0050702 ! interleukin-1 beta secretion

[Term]
id: GO:0050707
name: regulation of cytokine secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of cytokines from a cell." [GOC:ai]
is_a: GO:0001817 ! regulation of cytokine production
is_a: GO:0050708 ! regulation of protein secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050663 ! cytokine secretion
relationship: regulates GO:0050663 ! cytokine secretion

[Term]
id: GO:0050708
name: regulation of protein secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell." [GOC:ai]
subset: gosubset_prok
is_a: GO:0051223 ! regulation of protein transport
is_a: GO:1903530 ! regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009306 ! protein secretion
relationship: regulates GO:0009306 ! protein secretion

[Term]
id: GO:0050709
name: negative regulation of protein secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell." [GOC:ai]
synonym: "down regulation of protein secretion" EXACT []
synonym: "down-regulation of protein secretion" EXACT []
synonym: "downregulation of protein secretion" EXACT []
synonym: "inhibition of protein secretion" NARROW []
is_a: GO:0050708 ! regulation of protein secretion
is_a: GO:0051224 ! negative regulation of protein transport
is_a: GO:1903531 ! negative regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009306 ! protein secretion
relationship: negatively_regulates GO:0009306 ! protein secretion

[Term]
id: GO:0050710
name: negative regulation of cytokine secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of cytokines from a cell." [GOC:ai]
synonym: "down regulation of cytokine secretion" EXACT []
synonym: "down-regulation of cytokine secretion" EXACT []
synonym: "downregulation of cytokine secretion" EXACT []
synonym: "inhibition of cytokine secretion" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0050707 ! regulation of cytokine secretion
is_a: GO:0050709 ! negative regulation of protein secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0050663 ! cytokine secretion
relationship: negatively_regulates GO:0050663 ! cytokine secretion

[Term]
id: GO:0050711
name: negative regulation of interleukin-1 secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of interleukin-1 from a cell." [GOC:ai]
synonym: "down regulation of interleukin-1 secretion" EXACT []
synonym: "down-regulation of interleukin-1 secretion" EXACT []
synonym: "downregulation of interleukin-1 secretion" EXACT []
synonym: "inhibition of interleukin-1 secretion" NARROW []
is_a: GO:0032692 ! negative regulation of interleukin-1 production
is_a: GO:0050704 ! regulation of interleukin-1 secretion
is_a: GO:0050710 ! negative regulation of cytokine secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0050701 ! interleukin-1 secretion
relationship: negatively_regulates GO:0050701 ! interleukin-1 secretion

[Term]
id: GO:0050712
name: negative regulation of interleukin-1 alpha secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of interleukin-1 alpha from a cell." [GOC:ai]
synonym: "down regulation of interleukin-1 alpha secretion" EXACT []
synonym: "down-regulation of interleukin-1 alpha secretion" EXACT []
synonym: "downregulation of interleukin-1 alpha secretion" EXACT []
synonym: "inhibition of interleukin-1 alpha secretion" NARROW []
is_a: GO:0032690 ! negative regulation of interleukin-1 alpha production
is_a: GO:0050705 ! regulation of interleukin-1 alpha secretion
is_a: GO:0050711 ! negative regulation of interleukin-1 secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0050703 ! interleukin-1 alpha secretion
relationship: negatively_regulates GO:0050703 ! interleukin-1 alpha secretion

[Term]
id: GO:0050713
name: negative regulation of interleukin-1 beta secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell." [GOC:ai]
synonym: "down regulation of interleukin-1 beta secretion" EXACT []
synonym: "down-regulation of interleukin-1 beta secretion" EXACT []
synonym: "downregulation of interleukin-1 beta secretion" EXACT []
synonym: "inhibition of interleukin-1 beta secretion" NARROW []
is_a: GO:0032691 ! negative regulation of interleukin-1 beta production
is_a: GO:0050706 ! regulation of interleukin-1 beta secretion
is_a: GO:0050711 ! negative regulation of interleukin-1 secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0050702 ! interleukin-1 beta secretion
relationship: negatively_regulates GO:0050702 ! interleukin-1 beta secretion

[Term]
id: GO:0050714
name: positive regulation of protein secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell." [GOC:ai]
synonym: "activation of protein secretion" NARROW []
synonym: "stimulation of protein secretion" NARROW []
synonym: "up regulation of protein secretion" EXACT []
synonym: "up-regulation of protein secretion" EXACT []
synonym: "upregulation of protein secretion" EXACT []
is_a: GO:0050708 ! regulation of protein secretion
is_a: GO:0051222 ! positive regulation of protein transport
is_a: GO:1903532 ! positive regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009306 ! protein secretion
relationship: positively_regulates GO:0009306 ! protein secretion

[Term]
id: GO:0050715
name: positive regulation of cytokine secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of cytokines from a cell." [GOC:ai]
synonym: "activation of cytokine secretion" NARROW []
synonym: "stimulation of cytokine secretion" NARROW []
synonym: "up regulation of cytokine secretion" EXACT []
synonym: "up-regulation of cytokine secretion" EXACT []
synonym: "upregulation of cytokine secretion" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0050707 ! regulation of cytokine secretion
is_a: GO:0050714 ! positive regulation of protein secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0050663 ! cytokine secretion
relationship: positively_regulates GO:0050663 ! cytokine secretion

[Term]
id: GO:0050716
name: positive regulation of interleukin-1 secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 from a cell." [GOC:ai]
synonym: "activation of interleukin-1 secretion" NARROW []
synonym: "stimulation of interleukin-1 secretion" NARROW []
synonym: "up regulation of interleukin-1 secretion" EXACT []
synonym: "up-regulation of interleukin-1 secretion" EXACT []
synonym: "upregulation of interleukin-1 secretion" EXACT []
is_a: GO:0032732 ! positive regulation of interleukin-1 production
is_a: GO:0050704 ! regulation of interleukin-1 secretion
is_a: GO:0050715 ! positive regulation of cytokine secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0050701 ! interleukin-1 secretion
relationship: positively_regulates GO:0050701 ! interleukin-1 secretion

[Term]
id: GO:0050717
name: positive regulation of interleukin-1 alpha secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 alpha from a cell." [GOC:ai]
synonym: "activation of interleukin-1 alpha secretion" NARROW []
synonym: "stimulation of interleukin-1 alpha secretion" NARROW []
synonym: "up regulation of interleukin-1 alpha secretion" EXACT []
synonym: "up-regulation of interleukin-1 alpha secretion" EXACT []
synonym: "upregulation of interleukin-1 alpha secretion" EXACT []
is_a: GO:0032730 ! positive regulation of interleukin-1 alpha production
is_a: GO:0050705 ! regulation of interleukin-1 alpha secretion
is_a: GO:0050716 ! positive regulation of interleukin-1 secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0050703 ! interleukin-1 alpha secretion
relationship: positively_regulates GO:0050703 ! interleukin-1 alpha secretion

[Term]
id: GO:0050718
name: positive regulation of interleukin-1 beta secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell." [GOC:ai]
synonym: "activation of interleukin-1 beta secretion" NARROW []
synonym: "stimulation of interleukin-1 beta secretion" NARROW []
synonym: "up regulation of interleukin-1 beta secretion" EXACT []
synonym: "up-regulation of interleukin-1 beta secretion" EXACT []
synonym: "upregulation of interleukin-1 beta secretion" EXACT []
is_a: GO:0032731 ! positive regulation of interleukin-1 beta production
is_a: GO:0050706 ! regulation of interleukin-1 beta secretion
is_a: GO:0050716 ! positive regulation of interleukin-1 secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0050702 ! interleukin-1 beta secretion
relationship: positively_regulates GO:0050702 ! interleukin-1 beta secretion

[Term]
id: GO:0050719
name: interleukin-1 alpha biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-1 alpha." [GOC:ai]
synonym: "interleukin-1 alpha anabolism" EXACT []
synonym: "interleukin-1 alpha biosynthesis" EXACT []
synonym: "interleukin-1 alpha formation" EXACT []
synonym: "interleukin-1 alpha synthesis" EXACT []
is_a: GO:0042222 ! interleukin-1 biosynthetic process
relationship: part_of GO:0032610 ! interleukin-1 alpha production

[Term]
id: GO:0050720
name: interleukin-1 beta biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-1 beta." [GOC:ai]
synonym: "interleukin-1 beta anabolism" EXACT []
synonym: "interleukin-1 beta biosynthesis" EXACT []
synonym: "interleukin-1 beta formation" EXACT []
synonym: "interleukin-1 beta synthesis" EXACT []
is_a: GO:0042222 ! interleukin-1 biosynthetic process
relationship: part_of GO:0032611 ! interleukin-1 beta production

[Term]
id: GO:0050721
name: regulation of interleukin-1 alpha biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 alpha." [GOC:ai]
synonym: "regulation of interleukin-1 alpha anabolism" EXACT []
synonym: "regulation of interleukin-1 alpha biosynthesis" EXACT []
synonym: "regulation of interleukin-1 alpha formation" EXACT []
synonym: "regulation of interleukin-1 alpha synthesis" EXACT []
is_a: GO:0032650 ! regulation of interleukin-1 alpha production
is_a: GO:0045360 ! regulation of interleukin-1 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050719 ! interleukin-1 alpha biosynthetic process
relationship: regulates GO:0050719 ! interleukin-1 alpha biosynthetic process

[Term]
id: GO:0050722
name: regulation of interleukin-1 beta biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 beta." [GOC:ai]
synonym: "regulation of interleukin-1 beta anabolism" EXACT []
synonym: "regulation of interleukin-1 beta biosynthesis" EXACT []
synonym: "regulation of interleukin-1 beta formation" EXACT []
synonym: "regulation of interleukin-1 beta synthesis" EXACT []
is_a: GO:0032651 ! regulation of interleukin-1 beta production
is_a: GO:0045360 ! regulation of interleukin-1 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050720 ! interleukin-1 beta biosynthetic process
relationship: regulates GO:0050720 ! interleukin-1 beta biosynthetic process

[Term]
id: GO:0050723
name: negative regulation of interleukin-1 alpha biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 alpha." [GOC:ai]
synonym: "down regulation of interleukin-1 alpha biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-1 alpha biosynthetic process" EXACT []
synonym: "downregulation of interleukin-1 alpha biosynthetic process" EXACT []
synonym: "inhibition of interleukin-1 alpha biosynthetic process" NARROW []
synonym: "negative regulation of interleukin-1 alpha anabolism" EXACT []
synonym: "negative regulation of interleukin-1 alpha biosynthesis" EXACT []
synonym: "negative regulation of interleukin-1 alpha formation" EXACT []
synonym: "negative regulation of interleukin-1 alpha synthesis" EXACT []
is_a: GO:0032690 ! negative regulation of interleukin-1 alpha production
is_a: GO:0045361 ! negative regulation of interleukin-1 biosynthetic process
is_a: GO:0050721 ! regulation of interleukin-1 alpha biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0050719 ! interleukin-1 alpha biosynthetic process
relationship: negatively_regulates GO:0050719 ! interleukin-1 alpha biosynthetic process

[Term]
id: GO:0050724
name: negative regulation of interleukin-1 beta biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 beta." [GOC:ai]
synonym: "down regulation of interleukin-1 beta biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-1 beta biosynthetic process" EXACT []
synonym: "downregulation of interleukin-1 beta biosynthetic process" EXACT []
synonym: "inhibition of interleukin-1 beta biosynthetic process" NARROW []
synonym: "negative regulation of interleukin-1 beta anabolism" EXACT []
synonym: "negative regulation of interleukin-1 beta biosynthesis" EXACT []
synonym: "negative regulation of interleukin-1 beta formation" EXACT []
synonym: "negative regulation of interleukin-1 beta synthesis" EXACT []
is_a: GO:0032691 ! negative regulation of interleukin-1 beta production
is_a: GO:0045361 ! negative regulation of interleukin-1 biosynthetic process
is_a: GO:0050722 ! regulation of interleukin-1 beta biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0050720 ! interleukin-1 beta biosynthetic process
relationship: negatively_regulates GO:0050720 ! interleukin-1 beta biosynthetic process

[Term]
id: GO:0050725
name: positive regulation of interleukin-1 beta biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 beta." [GOC:ai]
synonym: "activation of interleukin-1 beta biosynthetic process" NARROW []
synonym: "positive regulation of interleukin-1 beta anabolism" EXACT []
synonym: "positive regulation of interleukin-1 beta biosynthesis" EXACT []
synonym: "positive regulation of interleukin-1 beta formation" EXACT []
synonym: "positive regulation of interleukin-1 beta synthesis" EXACT []
synonym: "stimulation of interleukin-1 beta biosynthetic process" NARROW []
synonym: "up regulation of interleukin-1 beta biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-1 beta biosynthetic process" EXACT []
synonym: "upregulation of interleukin-1 beta biosynthetic process" EXACT []
is_a: GO:0032731 ! positive regulation of interleukin-1 beta production
is_a: GO:0045362 ! positive regulation of interleukin-1 biosynthetic process
is_a: GO:0050722 ! regulation of interleukin-1 beta biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0050720 ! interleukin-1 beta biosynthetic process
relationship: positively_regulates GO:0050720 ! interleukin-1 beta biosynthetic process

[Term]
id: GO:0050726
name: positive regulation of interleukin-1 alpha biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 alpha." [GOC:ai]
synonym: "activation of interleukin-1 alpha biosynthetic process" NARROW []
synonym: "positive regulation of interleukin-1 alpha anabolism" EXACT []
synonym: "positive regulation of interleukin-1 alpha biosynthesis" EXACT []
synonym: "positive regulation of interleukin-1 alpha formation" EXACT []
synonym: "positive regulation of interleukin-1 alpha synthesis" EXACT []
synonym: "stimulation of interleukin-1 alpha biosynthetic process" NARROW []
synonym: "up regulation of interleukin-1 alpha biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-1 alpha biosynthetic process" EXACT []
synonym: "upregulation of interleukin-1 alpha biosynthetic process" EXACT []
is_a: GO:0032730 ! positive regulation of interleukin-1 alpha production
is_a: GO:0045362 ! positive regulation of interleukin-1 biosynthetic process
is_a: GO:0050721 ! regulation of interleukin-1 alpha biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0050719 ! interleukin-1 alpha biosynthetic process
relationship: positively_regulates GO:0050719 ! interleukin-1 alpha biosynthetic process

[Term]
id: GO:0050727
name: regulation of inflammatory response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents." [GOC:ai]
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0032101 ! regulation of response to external stimulus
is_a: GO:1903034 ! regulation of response to wounding
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006954 ! inflammatory response
relationship: regulates GO:0006954 ! inflammatory response

[Term]
id: GO:0050728
name: negative regulation of inflammatory response
namespace: biological_process
alt_id: GO:0030236
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response." [GOC:ai]
synonym: "anti-inflammatory response" EXACT []
synonym: "down regulation of inflammatory response" EXACT []
synonym: "down-regulation of inflammatory response" EXACT []
synonym: "downregulation of inflammatory response" EXACT []
synonym: "inhibition of inflammatory response" NARROW []
is_a: GO:0031348 ! negative regulation of defense response
is_a: GO:0032102 ! negative regulation of response to external stimulus
is_a: GO:0050727 ! regulation of inflammatory response
is_a: GO:1903035 ! negative regulation of response to wounding
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006954 ! inflammatory response
relationship: negatively_regulates GO:0006954 ! inflammatory response

[Term]
id: GO:0050729
name: positive regulation of inflammatory response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the inflammatory response." [GOC:ai]
synonym: "activation of inflammatory response" NARROW []
synonym: "stimulation of inflammatory response" NARROW []
synonym: "up regulation of inflammatory response" EXACT []
synonym: "up-regulation of inflammatory response" EXACT []
synonym: "upregulation of inflammatory response" EXACT []
is_a: GO:0031349 ! positive regulation of defense response
is_a: GO:0032103 ! positive regulation of response to external stimulus
is_a: GO:0050727 ! regulation of inflammatory response
is_a: GO:1903036 ! positive regulation of response to wounding
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006954 ! inflammatory response
relationship: positively_regulates GO:0006954 ! inflammatory response

[Term]
id: GO:0050730
name: regulation of peptidyl-tyrosine phosphorylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine." [GOC:ai]
subset: gosubset_prok
is_a: GO:0001932 ! regulation of protein phosphorylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0018108 ! peptidyl-tyrosine phosphorylation
relationship: regulates GO:0018108 ! peptidyl-tyrosine phosphorylation

[Term]
id: GO:0050731
name: positive regulation of peptidyl-tyrosine phosphorylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine." [GOC:ai]
subset: gosubset_prok
synonym: "activation of peptidyl-tyrosine phosphorylation" NARROW []
synonym: "stimulation of peptidyl-tyrosine phosphorylation" NARROW []
synonym: "up regulation of peptidyl-tyrosine phosphorylation" EXACT []
synonym: "up-regulation of peptidyl-tyrosine phosphorylation" EXACT []
synonym: "upregulation of peptidyl-tyrosine phosphorylation" EXACT []
is_a: GO:0001934 ! positive regulation of protein phosphorylation
is_a: GO:0050730 ! regulation of peptidyl-tyrosine phosphorylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0018108 ! peptidyl-tyrosine phosphorylation
relationship: positively_regulates GO:0018108 ! peptidyl-tyrosine phosphorylation

[Term]
id: GO:0050732
name: negative regulation of peptidyl-tyrosine phosphorylation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of peptidyl-tyrosine phosphorylation" EXACT []
synonym: "down-regulation of peptidyl-tyrosine phosphorylation" EXACT []
synonym: "downregulation of peptidyl-tyrosine phosphorylation" EXACT []
synonym: "inhibition of peptidyl-tyrosine phosphorylation" NARROW []
is_a: GO:0001933 ! negative regulation of protein phosphorylation
is_a: GO:0050730 ! regulation of peptidyl-tyrosine phosphorylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0018108 ! peptidyl-tyrosine phosphorylation
relationship: negatively_regulates GO:0018108 ! peptidyl-tyrosine phosphorylation

[Term]
id: GO:0050733
name: RS domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RS domain of a protein; RS domains are usually highly phosphorylated and characterized by the presence of arginine (R)/serine (S) dipeptides. The RS domain promotes protein-protein interactions and directs subcellular localization and, in certain situations, nucleocytoplasmic shuttling of individual SR proteins. They also play a role in splicing." [PMID:11684676, PMID:12215544]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0050734
name: hydroxycinnamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a hydroxycinnamoyl group to an acceptor molecule." [GOC:ai]
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0050735
name: N-malonyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a malonyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]
is_a: GO:0016410 ! N-acyltransferase activity
is_a: GO:0016420 ! malonyltransferase activity

[Term]
id: GO:0050736
name: O-malonyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a malonyl group to an oxygen atom on the acceptor molecule." [GOC:ai]
is_a: GO:0008374 ! O-acyltransferase activity
is_a: GO:0016420 ! malonyltransferase activity

[Term]
id: GO:0050737
name: O-hydroxycinnamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a hydroxycinnamoyl group to an oxygen atom on the acceptor molecule." [GOC:ai]
is_a: GO:0008374 ! O-acyltransferase activity
is_a: GO:0050734 ! hydroxycinnamoyltransferase activity

[Term]
id: GO:0050738
name: fructosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a fructosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai]
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0050739
name: peptide cross-linking via S-[5'-(L-tryptoph-6'-yl)-L-tyrosin-3'-yl]-L-methionin-S-ium
namespace: biological_process
def: "The cross-linking of a tyrosine residue to a tryptophan residue and a methionine residue to form S-[5'-(L-tryptoph-6'-yl)-L-tyrosin-3'-yl]-L-methionin-S-ium." [RESID:AA0348]
subset: gosubset_prok
xref: RESID:AA0348
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018206 ! peptidyl-methionine modification
is_a: GO:0018211 ! peptidyl-tryptophan modification
is_a: GO:0018212 ! peptidyl-tyrosine modification

[Term]
id: GO:0050740
name: protein-FMN linkage via O3-riboflavin phosphoryl-L-threonine
namespace: biological_process
def: "The formation of a protein-FMN linkage via O3-riboflavin phosphoryl-L-threonine." [RESID:AA0349]
subset: gosubset_prok
xref: RESID:AA0349
is_a: GO:0018309 ! protein-FMN linkage

[Term]
id: GO:0050741
name: protein-FMN linkage via O3-riboflavin phosphoryl-L-serine
namespace: biological_process
def: "The formation of a protein-FMN linkage via O3-riboflavin phosphoryl-L-serine." [RESID:AA0350]
subset: gosubset_prok
xref: RESID:AA0350
is_a: GO:0018309 ! protein-FMN linkage

[Term]
id: GO:0050742
name: protein-FMN linkage via S-(4a-FMN)-L-cysteine
namespace: biological_process
def: "The formation of a protein-FMN linkage via S-(4a-FMN)-L-cysteine." [RESID:AA0351]
subset: gosubset_prok
xref: RESID:AA0351
is_a: GO:0018309 ! protein-FMN linkage

[Term]
id: GO:0050743
name: protein-FMN linkage via 1'-(8alpha-FMN)-L-histidine
namespace: biological_process
def: "The formation of a protein-FMN linkage via 1'-(8alpha-FMN)-L-histidine." [PMID:8611516, RESID:AA0352]
subset: gosubset_prok
xref: RESID:AA0352
is_a: GO:0018309 ! protein-FMN linkage

[Term]
id: GO:0050744
name: protein-FMN linkage via 3'-(8alpha-FMN)-L-histidine
namespace: biological_process
def: "The formation of a protein-FMN linkage via 3'-(8alpha-FMN)-L-histidine." [RESID:AA0353]
subset: gosubset_prok
xref: RESID:AA0353
is_a: GO:0018309 ! protein-FMN linkage

[Term]
id: GO:0050745
name: peptide cross-linking via L-cysteinyl-5-imidazolinone glycine
namespace: biological_process
def: "The formation of a protein active site cross-link from the alpha-carboxyl carbon of residue N, a cysteine, to the alpha-amino nitrogen of residue N+2, a glycine, coupled with the formation of a double bond to the alpha-amino nitrogen of residue N+1 which loses one hydrogen, and the loss of a molecule of water." [RESID:AA0188]
subset: gosubset_prok
xref: RESID:AA0188
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018253 ! peptide cross-linking via 5-imidazolinone glycine

[Term]
id: GO:0050746
name: regulation of lipoprotein metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids." [GOC:ai]
subset: gosubset_prok
synonym: "regulation of lipoprotein metabolism" EXACT []
is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:0051246 ! regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042157 ! lipoprotein metabolic process
relationship: regulates GO:0042157 ! lipoprotein metabolic process

[Term]
id: GO:0050747
name: positive regulation of lipoprotein metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids." [GOC:ai]
subset: gosubset_prok
synonym: "activation of lipoprotein metabolic process" NARROW []
synonym: "positive regulation of lipoprotein metabolism" EXACT []
synonym: "stimulation of lipoprotein metabolic process" NARROW []
synonym: "up regulation of lipoprotein metabolic process" EXACT []
synonym: "up-regulation of lipoprotein metabolic process" EXACT []
synonym: "upregulation of lipoprotein metabolic process" EXACT []
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0050746 ! regulation of lipoprotein metabolic process
is_a: GO:0051247 ! positive regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042157 ! lipoprotein metabolic process
relationship: positively_regulates GO:0042157 ! lipoprotein metabolic process

[Term]
id: GO:0050748
name: negative regulation of lipoprotein metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of lipoprotein metabolic process" EXACT []
synonym: "down-regulation of lipoprotein metabolic process" EXACT []
synonym: "downregulation of lipoprotein metabolic process" EXACT []
synonym: "inhibition of lipoprotein metabolic process" NARROW []
synonym: "negative regulation of lipoprotein metabolism" EXACT []
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0050746 ! regulation of lipoprotein metabolic process
is_a: GO:0051248 ! negative regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042157 ! lipoprotein metabolic process
relationship: negatively_regulates GO:0042157 ! lipoprotein metabolic process

[Term]
id: GO:0050749
name: obsolete apolipoprotein E receptor binding
namespace: molecular_function
def: "OBSOLETE. Interacting selectively with an apolipoprotein E receptor." [GOC:ai]
comment: This term was made obsolete because no known receptor binds apolipoprotein E; instead, receptors bind holo-lipoprotein E (apolipoprotein E + bound lipid).
synonym: "apolipoprotein E receptor binding" EXACT []
is_obsolete: true
replaced_by: GO:0070326

[Term]
id: GO:0050750
name: low-density lipoprotein particle receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a low-density lipoprotein receptor." [GOC:ai]
synonym: "LDL receptor binding" EXACT []
synonym: "low-density lipoprotein receptor binding" EXACT [GOC:dph]
is_a: GO:0070325 ! lipoprotein particle receptor binding

[Term]
id: GO:0050751
name: fractalkine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of fractalkine, a chemokine involved in the control of the key regulatory mechanisms of cell trafficking at sites of inflammation. It exists as a secreted protein and in a membrane-bound form, and exhibits a novel C-X-X-X-C cysteine signature motif. The counterpart of human fractalkine is murine neurotactin; fractalkine is also referred to as CX3C membrane-anchored chemokine or ABCD-3 and has been renamed CX3CL1." [http://www.copewithcytokines.de]
synonym: "ABCD-3 biosynthesis" EXACT []
synonym: "ABCD-3 biosynthetic process" EXACT []
synonym: "CX3C membrane-anchored chemokine biosynthesis" EXACT []
synonym: "CX3C membrane-anchored chemokine biosynthetic process" EXACT []
synonym: "CX3CL1 biosynthesis" EXACT []
synonym: "CX3CL1 biosynthetic process" EXACT []
synonym: "fractalkine anabolism" EXACT []
synonym: "fractalkine biosynthesis" EXACT []
synonym: "fractalkine formation" EXACT []
synonym: "fractalkine synthesis" EXACT []
synonym: "neurotactin biosynthesis" EXACT []
synonym: "neurotactin biosynthetic process" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0042033 ! chemokine biosynthetic process
is_a: GO:0050756 ! fractalkine metabolic process
relationship: part_of GO:0032603 ! fractalkine production

[Term]
id: GO:0050752
name: regulation of fractalkine biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fractalkine, a chemokine involved in the control of the key regulatory mechanisms of cell trafficking at sites of inflammation." [http://www.copewithcytokines.de]
synonym: "regulation of CX3CL1 biosynthesis" EXACT []
synonym: "regulation of CX3CL1 biosynthetic process" EXACT []
synonym: "regulation of fractalkine anabolism" EXACT []
synonym: "regulation of fractalkine biosynthesis" EXACT []
synonym: "regulation of fractalkine formation" EXACT []
synonym: "regulation of fractalkine synthesis" EXACT []
synonym: "regulation of neurotactin biosynthesis" EXACT []
synonym: "regulation of neurotactin biosynthetic process" EXACT []
is_a: GO:0032644 ! regulation of fractalkine production
is_a: GO:0045073 ! regulation of chemokine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050751 ! fractalkine biosynthetic process
relationship: regulates GO:0050751 ! fractalkine biosynthetic process

[Term]
id: GO:0050753
name: negative regulation of fractalkine biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fractalkine, a chemokine involved in the control of the key regulatory mechanisms of cell trafficking at sites of inflammation." [http://www.copewithcytokines.de]
synonym: "down regulation of fractalkine biosynthetic process" EXACT []
synonym: "down-regulation of fractalkine biosynthetic process" EXACT []
synonym: "downregulation of fractalkine biosynthetic process" EXACT []
synonym: "inhibition of fractalkine biosynthetic process" NARROW []
synonym: "negative regulation of CX3CL1 biosynthesis" EXACT []
synonym: "negative regulation of CX3CL1 biosynthetic process" EXACT []
synonym: "negative regulation of fractalkine anabolism" EXACT []
synonym: "negative regulation of fractalkine biosynthesis" EXACT []
synonym: "negative regulation of fractalkine formation" EXACT []
synonym: "negative regulation of fractalkine synthesis" EXACT []
synonym: "negative regulation of neurotactin biosynthesis" EXACT []
synonym: "negative regulation of neurotactin biosynthetic process" EXACT []
is_a: GO:0032684 ! negative regulation of fractalkine production
is_a: GO:0045079 ! negative regulation of chemokine biosynthetic process
is_a: GO:0050752 ! regulation of fractalkine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0050751 ! fractalkine biosynthetic process
relationship: negatively_regulates GO:0050751 ! fractalkine biosynthetic process

[Term]
id: GO:0050754
name: positive regulation of fractalkine biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fractalkine, a chemokine involved in the control of the key regulatory mechanisms of cell trafficking at sites of inflammation." [http://www.copewithcytokines.de]
synonym: "activation of fractalkine biosynthetic process" NARROW []
synonym: "positive regulation of CX3CL1 biosynthesis" EXACT []
synonym: "positive regulation of CX3CL1 biosynthetic process" EXACT []
synonym: "positive regulation of fractalkine anabolism" EXACT []
synonym: "positive regulation of fractalkine biosynthesis" EXACT []
synonym: "positive regulation of fractalkine formation" EXACT []
synonym: "positive regulation of fractalkine synthesis" EXACT []
synonym: "positive regulation of neurotactin biosynthesis" EXACT []
synonym: "positive regulation of neurotactin biosynthetic process" EXACT []
synonym: "stimulation of fractalkine biosynthetic process" NARROW []
synonym: "up regulation of fractalkine biosynthetic process" EXACT []
synonym: "up-regulation of fractalkine biosynthetic process" EXACT []
synonym: "upregulation of fractalkine biosynthetic process" EXACT []
is_a: GO:0032724 ! positive regulation of fractalkine production
is_a: GO:0045080 ! positive regulation of chemokine biosynthetic process
is_a: GO:0050752 ! regulation of fractalkine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0050751 ! fractalkine biosynthetic process
relationship: positively_regulates GO:0050751 ! fractalkine biosynthetic process

[Term]
id: GO:0050755
name: chemokine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving chemokines, any member of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria." [GOC:BHF, GOC:rl, http://en.wikipedia.org/wiki/Chemokine, ISBN:0198506732, PMID:12183377]
synonym: "chemokine metabolism" EXACT []
is_a: GO:0042107 ! cytokine metabolic process

[Term]
id: GO:0050756
name: fractalkine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fractalkine, a chemokine involved in the control of the key regulatory mechanisms of cell trafficking at sites of inflammation. It exists as a secreted protein and in a membrane-bound form, and exhibits a novel C-X-X-X-C cysteine signature motif. The counterpart of human fractalkine is murine neurotactin; fractalkine is also referred to as CX3C membrane-anchored chemokine or ABCD-3 and has been renamed CX3CL1." [http://www.copewithcytokines.de]
synonym: "ABCD-3 metabolic process" EXACT []
synonym: "ABCD-3 metabolism" EXACT []
synonym: "CX3C membrane-anchored chemokine metabolic process" EXACT []
synonym: "CX3C membrane-anchored chemokine metabolism" EXACT []
synonym: "CX3CL1 metabolic process" EXACT []
synonym: "CX3CL1 metabolism" EXACT []
synonym: "fractalkine metabolism" EXACT []
synonym: "neurotactin metabolic process" EXACT []
synonym: "neurotactin metabolism" EXACT []
is_a: GO:0050755 ! chemokine metabolic process

[Term]
id: GO:0050757
name: thymidylate synthase biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the enzyme thymidylate synthase, which catalyzes the reaction: 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP." [EC:2.1.1.45]
subset: gosubset_prok
synonym: "thymidylate synthase anabolism" EXACT []
synonym: "thymidylate synthase biosynthesis" EXACT []
synonym: "thymidylate synthase formation" EXACT []
synonym: "thymidylate synthase synthesis" EXACT []
is_a: GO:0009059 ! macromolecule biosynthetic process
is_a: GO:0019538 ! protein metabolic process

[Term]
id: GO:0050758
name: regulation of thymidylate synthase biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme thymidylate synthase." [GOC:ai]
subset: gosubset_prok
synonym: "regulation of thymidylate synthase anabolism" EXACT []
synonym: "regulation of thymidylate synthase biosynthesis" EXACT []
synonym: "regulation of thymidylate synthase formation" EXACT []
synonym: "regulation of thymidylate synthase synthesis" EXACT []
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
is_a: GO:0051246 ! regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050757 ! thymidylate synthase biosynthetic process
relationship: regulates GO:0050757 ! thymidylate synthase biosynthetic process

[Term]
id: GO:0050759
name: positive regulation of thymidylate synthase biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme thymidylate synthase." [GOC:ai]
subset: gosubset_prok
synonym: "activation of thymidylate synthase biosynthetic process" NARROW []
synonym: "positive regulation of thymidylate synthase anabolism" EXACT []
synonym: "positive regulation of thymidylate synthase biosynthesis" EXACT []
synonym: "positive regulation of thymidylate synthase formation" EXACT []
synonym: "positive regulation of thymidylate synthase synthesis" EXACT []
synonym: "stimulation of thymidylate synthase biosynthetic process" NARROW []
synonym: "up regulation of thymidylate synthase biosynthetic process" EXACT []
synonym: "up-regulation of thymidylate synthase biosynthetic process" EXACT []
synonym: "upregulation of thymidylate synthase biosynthetic process" EXACT []
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0050758 ! regulation of thymidylate synthase biosynthetic process
is_a: GO:0051247 ! positive regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0050757 ! thymidylate synthase biosynthetic process
relationship: positively_regulates GO:0050757 ! thymidylate synthase biosynthetic process

[Term]
id: GO:0050760
name: negative regulation of thymidylate synthase biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme thymidylate synthase." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of thymidylate synthase biosynthetic process" EXACT []
synonym: "down-regulation of thymidylate synthase biosynthetic process" EXACT []
synonym: "downregulation of thymidylate synthase biosynthetic process" EXACT []
synonym: "inhibition of thymidylate synthase biosynthetic process" NARROW []
synonym: "negative regulation of thymidylate synthase anabolism" EXACT []
synonym: "negative regulation of thymidylate synthase biosynthesis" EXACT []
synonym: "negative regulation of thymidylate synthase formation" EXACT []
synonym: "negative regulation of thymidylate synthase synthesis" EXACT []
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
is_a: GO:0050758 ! regulation of thymidylate synthase biosynthetic process
is_a: GO:0051248 ! negative regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0050757 ! thymidylate synthase biosynthetic process
relationship: negatively_regulates GO:0050757 ! thymidylate synthase biosynthetic process

[Term]
id: GO:0050761
name: depsipeptide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving depsipeptides, a linear or cyclic compound composed of both amino acids and hydroxy acids in peptide and ester bonds respectively." [GOC:go_curators]
subset: goslim_pir
subset: gosubset_prok
synonym: "depsipeptide metabolism" EXACT []
is_a: GO:0006518 ! peptide metabolic process

[Term]
id: GO:0050762
name: depsipeptide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of depsipeptides, a linear or cyclic compound composed of both amino acids and hydroxy acids in peptide and ester bonds respectively." [GOC:go_curators]
subset: gosubset_prok
synonym: "depsipeptide breakdown" EXACT []
synonym: "depsipeptide catabolism" EXACT []
synonym: "depsipeptide degradation" EXACT []
is_a: GO:0043171 ! peptide catabolic process
is_a: GO:0050761 ! depsipeptide metabolic process

[Term]
id: GO:0050763
name: depsipeptide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of depsipeptides, a linear or cyclic compound composed of both amino acids and hydroxy acids in peptide and ester bonds respectively." [GOC:go_curators]
subset: gosubset_prok
synonym: "depsipeptide anabolism" EXACT []
synonym: "depsipeptide biosynthesis" EXACT []
synonym: "depsipeptide formation" EXACT []
synonym: "depsipeptide synthesis" EXACT []
is_a: GO:0043043 ! peptide biosynthetic process
is_a: GO:0050761 ! depsipeptide metabolic process

[Term]
id: GO:0050764
name: regulation of phagocytosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material." [GOC:ai]
is_a: GO:0030100 ! regulation of endocytosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006909 ! phagocytosis
relationship: regulates GO:0006909 ! phagocytosis

[Term]
id: GO:0050765
name: negative regulation of phagocytosis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of phagocytosis." [GOC:ai]
synonym: "down regulation of phagocytosis" EXACT []
synonym: "down-regulation of phagocytosis" EXACT []
synonym: "downregulation of phagocytosis" EXACT []
synonym: "inhibition of phagocytosis" NARROW []
is_a: GO:0045806 ! negative regulation of endocytosis
is_a: GO:0050764 ! regulation of phagocytosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006909 ! phagocytosis
relationship: negatively_regulates GO:0006909 ! phagocytosis

[Term]
id: GO:0050766
name: positive regulation of phagocytosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phagocytosis." [GOC:ai]
synonym: "activation of phagocytosis" NARROW []
synonym: "stimulation of phagocytosis" NARROW []
synonym: "up regulation of phagocytosis" EXACT []
synonym: "up-regulation of phagocytosis" EXACT []
synonym: "upregulation of phagocytosis" EXACT []
is_a: GO:0045807 ! positive regulation of endocytosis
is_a: GO:0050764 ! regulation of phagocytosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006909 ! phagocytosis
relationship: positively_regulates GO:0006909 ! phagocytosis

[Term]
id: GO:0050767
name: regulation of neurogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neurogenesis, the origin and formation of neurons." [GOC:ai]
is_a: GO:0051960 ! regulation of nervous system development
is_a: GO:0060284 ! regulation of cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0022008 ! neurogenesis
relationship: part_of GO:0048699 ! generation of neurons
relationship: regulates GO:0022008 ! neurogenesis

[Term]
id: GO:0050768
name: negative regulation of neurogenesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the origin and formation of neurons." [GOC:ai]
synonym: "down regulation of neurogenesis" EXACT []
synonym: "down-regulation of neurogenesis" EXACT []
synonym: "downregulation of neurogenesis" EXACT []
synonym: "inhibition of neurogenesis" NARROW []
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0050767 ! regulation of neurogenesis
is_a: GO:0051961 ! negative regulation of nervous system development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0022008 ! neurogenesis
relationship: negatively_regulates GO:0022008 ! neurogenesis

[Term]
id: GO:0050769
name: positive regulation of neurogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neurogenesis, the origin and formation of neurons." [GOC:ai]
synonym: "activation of neurogenesis" NARROW []
synonym: "stimulation of neurogenesis" NARROW []
synonym: "up regulation of neurogenesis" EXACT []
synonym: "up-regulation of neurogenesis" EXACT []
synonym: "upregulation of neurogenesis" EXACT []
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0050767 ! regulation of neurogenesis
is_a: GO:0051962 ! positive regulation of nervous system development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0022008 ! neurogenesis
relationship: positively_regulates GO:0022008 ! neurogenesis

[Term]
id: GO:0050770
name: regulation of axonogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron." [GOC:ai]
xref: Reactome:REACT_100877 "p75NTR regulates axonogenesis, Taeniopygia guttata"
xref: Reactome:REACT_103034 "p75NTR regulates axonogenesis, Sus scrofa"
xref: Reactome:REACT_105471 "p75NTR regulates axonogenesis, Xenopus tropicalis"
xref: Reactome:REACT_109191 "p75NTR regulates axonogenesis, Gallus gallus"
xref: Reactome:REACT_13620 "p75NTR regulates axonogenesis, Homo sapiens"
xref: Reactome:REACT_28624 "p75NTR regulates axonogenesis, Rattus norvegicus"
xref: Reactome:REACT_31549 "p75NTR regulates axonogenesis, Danio rerio"
xref: Reactome:REACT_78884 "p75NTR regulates axonogenesis, Caenorhabditis elegans"
xref: Reactome:REACT_89480 "p75NTR regulates axonogenesis, Canis familiaris"
xref: Reactome:REACT_89995 "p75NTR regulates axonogenesis, Mus musculus"
xref: Reactome:REACT_93864 "p75NTR regulates axonogenesis, Bos taurus"
xref: Reactome:REACT_96905 "p75NTR regulates axonogenesis, Drosophila melanogaster"
is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation
is_a: GO:0010975 ! regulation of neuron projection development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007409 ! axonogenesis
relationship: regulates GO:0007409 ! axonogenesis

[Term]
id: GO:0050771
name: negative regulation of axonogenesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of axonogenesis." [GOC:ai]
synonym: "down regulation of axonogenesis" EXACT []
synonym: "down-regulation of axonogenesis" EXACT []
synonym: "downregulation of axonogenesis" EXACT []
synonym: "inhibition of axonogenesis" NARROW []
xref: Reactome:REACT_103974 "Axonal growth inhibition (RHOA activation), Danio rerio"
xref: Reactome:REACT_105638 "Axonal growth inhibition (RHOA activation), Mus musculus"
xref: Reactome:REACT_13815 "Axonal growth inhibition (RHOA activation), Homo sapiens"
xref: Reactome:REACT_29558 "Axonal growth inhibition (RHOA activation), Caenorhabditis elegans"
xref: Reactome:REACT_32480 "Axonal growth inhibition (RHOA activation), Rattus norvegicus"
xref: Reactome:REACT_79935 "Axonal growth inhibition (RHOA activation), Drosophila melanogaster"
xref: Reactome:REACT_84319 "Axonal growth inhibition (RHOA activation), Xenopus tropicalis"
xref: Reactome:REACT_89521 "Axonal growth inhibition (RHOA activation), Bos taurus"
xref: Reactome:REACT_95704 "Axonal growth inhibition (RHOA activation), Canis familiaris"
xref: Reactome:REACT_97524 "Axonal growth inhibition (RHOA activation), Sus scrofa"
xref: Reactome:REACT_97819 "Axonal growth inhibition (RHOA activation), Gallus gallus"
xref: Reactome:REACT_99775 "Axonal growth inhibition (RHOA activation), Taeniopygia guttata"
is_a: GO:0010771 ! negative regulation of cell morphogenesis involved in differentiation
is_a: GO:0010977 ! negative regulation of neuron projection development
is_a: GO:0050770 ! regulation of axonogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007409 ! axonogenesis
relationship: negatively_regulates GO:0007409 ! axonogenesis

[Term]
id: GO:0050772
name: positive regulation of axonogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of axonogenesis." [GOC:ai]
synonym: "activation of axonogenesis" NARROW []
synonym: "stimulation of axonogenesis" NARROW []
synonym: "up regulation of axonogenesis" EXACT []
synonym: "up-regulation of axonogenesis" EXACT []
synonym: "upregulation of axonogenesis" EXACT []
xref: Reactome:REACT_104800 "Axonal growth stimulation, Bos taurus"
xref: Reactome:REACT_108274 "Axonal growth stimulation, Canis familiaris"
xref: Reactome:REACT_112731 "Axonal growth stimulation, Danio rerio"
xref: Reactome:REACT_113936 "Axonal growth stimulation, Rattus norvegicus"
xref: Reactome:REACT_13779 "Axonal growth stimulation, Homo sapiens"
xref: Reactome:REACT_29835 "Axonal growth stimulation, Xenopus tropicalis"
xref: Reactome:REACT_80113 "Axonal growth stimulation, Mus musculus"
xref: Reactome:REACT_84675 "Axonal growth stimulation, Gallus gallus"
is_a: GO:0010770 ! positive regulation of cell morphogenesis involved in differentiation
is_a: GO:0010976 ! positive regulation of neuron projection development
is_a: GO:0050770 ! regulation of axonogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007409 ! axonogenesis
relationship: positively_regulates GO:0007409 ! axonogenesis

[Term]
id: GO:0050773
name: regulation of dendrite development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dendrite development." [GOC:ai]
is_a: GO:0010975 ! regulation of neuron projection development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016358 ! dendrite development
relationship: regulates GO:0016358 ! dendrite development

[Term]
id: GO:0050774
name: negative regulation of dendrite morphogenesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite morphogenesis." [GOC:ai]
synonym: "down regulation of dendrite morphogenesis" EXACT []
synonym: "down-regulation of dendrite morphogenesis" EXACT []
synonym: "downregulation of dendrite morphogenesis" EXACT []
synonym: "inhibition of dendrite morphogenesis" NARROW []
is_a: GO:0010771 ! negative regulation of cell morphogenesis involved in differentiation
is_a: GO:0048814 ! regulation of dendrite morphogenesis
is_a: GO:2000171 ! negative regulation of dendrite development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048813 ! dendrite morphogenesis
relationship: negatively_regulates GO:0048813 ! dendrite morphogenesis

[Term]
id: GO:0050775
name: positive regulation of dendrite morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis." [GOC:ai]
synonym: "activation of dendrite morphogenesis" NARROW []
synonym: "stimulation of dendrite morphogenesis" NARROW []
synonym: "up regulation of dendrite morphogenesis" EXACT []
synonym: "up-regulation of dendrite morphogenesis" EXACT []
synonym: "upregulation of dendrite morphogenesis" EXACT []
is_a: GO:0010770 ! positive regulation of cell morphogenesis involved in differentiation
is_a: GO:0048814 ! regulation of dendrite morphogenesis
is_a: GO:1900006 ! positive regulation of dendrite development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048813 ! dendrite morphogenesis
relationship: positively_regulates GO:0048813 ! dendrite morphogenesis

[Term]
id: GO:0050776
name: regulation of immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai]
xref: Reactome:REACT_101484 "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Gallus gallus"
xref: Reactome:REACT_106667 "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Rattus norvegicus"
xref: Reactome:REACT_107426 "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Mus musculus"
xref: Reactome:REACT_11152 "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Homo sapiens"
xref: Reactome:REACT_81657 "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Danio rerio"
xref: Reactome:REACT_82803 "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Canis familiaris"
xref: Reactome:REACT_87475 "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Bos taurus"
xref: Reactome:REACT_94152 "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Sus scrofa"
xref: Reactome:REACT_95389 "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Taeniopygia guttata"
xref: Reactome:REACT_97860 "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Xenopus tropicalis"
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0048583 ! regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006955 ! immune response
relationship: regulates GO:0006955 ! immune response

[Term]
id: GO:0050777
name: negative regulation of immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai]
synonym: "down regulation of immune response" EXACT []
synonym: "down-regulation of immune response" EXACT []
synonym: "downregulation of immune response" EXACT []
synonym: "inhibition of immune response" NARROW []
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:0050776 ! regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006955 ! immune response
relationship: negatively_regulates GO:0006955 ! immune response

[Term]
id: GO:0050778
name: positive regulation of immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai]
synonym: "stimulation of immune response" NARROW []
synonym: "up regulation of immune response" EXACT []
synonym: "up-regulation of immune response" EXACT []
synonym: "upregulation of immune response" EXACT []
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:0050776 ! regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006955 ! immune response
relationship: positively_regulates GO:0006955 ! immune response

[Term]
id: GO:0050779
name: RNA destabilization
namespace: biological_process
def: "Any process that decreases the stability of an RNA molecule, making it more vulnerable to degradative processes." [GOC:ai]
subset: gosubset_prok
is_a: GO:0043487 ! regulation of RNA stability

[Term]
id: GO:0050780
name: dopamine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a dopamine receptor." [GOC:ai]
is_a: GO:0001664 ! G-protein coupled receptor binding

[Term]
id: GO:0050781
name: ortho-trichlorophenol reductive dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4,6-trichlorophenol + 2 H+ + 2 e- = 2,4-dichlorophenol + HCl." [GOC:ai, PMID:12697029]
subset: gosubset_prok
synonym: "2,4,6-TCP reductive dehalogenase activity" EXACT []
synonym: "2,4,6-trichlorophenol reductive dehalogenase activity" EXACT []
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0050782
name: galactose uniporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose (out) = galactose(in)." [GOC:ai, TC:2.A.1.1.6]
synonym: "galactose, glucose uniporter activity" BROAD []
is_a: GO:0005354 ! galactose transmembrane transporter activity
is_a: GO:0008516 ! hexose uniporter activity

[Term]
id: GO:0050783
name: cocaine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cocaine, an alkaloid obtained from the dried leaves of the shrub Erythroxylon coca. It is a cerebral stimulant and narcotic." [ISBN:0198506732]
subset: gosubset_prok
synonym: "cocaine metabolism" EXACT []
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0017144 ! drug metabolic process
is_a: GO:0046448 ! tropane alkaloid metabolic process
is_a: GO:0097164 ! ammonium ion metabolic process

[Term]
id: GO:0050784
name: cocaine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cocaine, an alkaloid obtained from the dried leaves of the shrub Erythroxylon coca. It is a cerebral stimulant and narcotic." [ISBN:0198506732]
subset: gosubset_prok
synonym: "cocaine breakdown" EXACT []
synonym: "cocaine catabolism" EXACT []
synonym: "cocaine degradation" EXACT []
is_a: GO:0009822 ! alkaloid catabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042737 ! drug catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:0050783 ! cocaine metabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process

[Term]
id: GO:0050785
name: advanced glycation end-product receptor activity
namespace: molecular_function
def: "Combining with advanced glycation end-products and transmitting the signal to initiate a change in cell activity. Advanced glycation end-products (AGEs) form from a series of chemical reactions after an initial glycation event (a non-enzymatic reaction between reducing sugars and free amino groups of proteins)." [GOC:signaling, PMID:12453678, PMID:12707408, PMID:7592757, PMID:9224812, Wikipedia:RAGE_(receptor)]
synonym: "AGE receptor activity" EXACT [PMID:21590515]
synonym: "RAGE activity" EXACT [PMID:21590515]
is_a: GO:0038023 ! signaling receptor activity

[Term]
id: GO:0050786
name: RAGE receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the RAGE receptor, the receptor for advanced glycation end-products." [GOC:ai]
synonym: "advanced glycation end-product receptor binding" EXACT []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0050787
name: detoxification of mercury ion
namespace: biological_process
def: "Any process that reduce or remove the toxicity of mercuric ion. These include transport of mercury away from sensitive areas and to compartments or complexes whose purpose is sequestration of mercury ion and/or reduction of mercury ion (Hg[II]) to metallic mercury (Hg[0])." [PMID:10774920]
subset: gosubset_prok
is_a: GO:0061687 ! detoxification of inorganic compound
relationship: part_of GO:0046689 ! response to mercury ion

[Term]
id: GO:0050788
name: sequestering of mercury
namespace: biological_process
def: "The process of binding or confining toxic mercury ions or atoms such that they are separated from sensitive components of a biological system." [PMID:10774920]
synonym: "mercuric ion (Hg2+) sequestering" EXACT []
synonym: "mercuric ion (Hg2+) sequestration" EXACT []
synonym: "mercury (Hg) ion sequestering" EXACT []
synonym: "mercury (Hg) ion sequestration" EXACT []
synonym: "mercury (Hg2+) ion retention" EXACT []
synonym: "mercury (Hg2+) ion storage" EXACT []
synonym: "retention of mercury (Hg2+) ion" EXACT []
synonym: "sequestering of mercuric ion (Hg2+)" EXACT []
synonym: "sequestering of mercury (Hg) ion" EXACT []
synonym: "sequestration of mercuric ion (Hg2+)" EXACT []
synonym: "sequestration of mercury (Hg) ion" EXACT []
synonym: "storage of mercury (Hg2+) ion" EXACT []
is_a: GO:0051238 ! sequestering of metal ion
relationship: part_of GO:0050787 ! detoxification of mercury ion

[Term]
id: GO:0050789
name: regulation of biological process
namespace: biological_process
alt_id: GO:0050791
def: "Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:ai, GOC:go_curators]
subset: goslim_aspergillus
subset: goslim_candida
subset: gosubset_prok
synonym: "regulation of physiological process" EXACT []
is_a: GO:0065007 ! biological regulation
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0008150 ! biological_process
relationship: regulates GO:0008150 ! biological_process

[Term]
id: GO:0050790
name: regulation of catalytic activity
namespace: biological_process
alt_id: GO:0048552
def: "Any process that modulates the activity of an enzyme." [GOC:ai, GOC:ebc]
subset: goslim_chembl
subset: gosubset_prok
synonym: "regulation of enzyme activity" EXACT []
synonym: "regulation of metalloenzyme activity" NARROW []
is_a: GO:0019222 ! regulation of metabolic process
is_a: GO:0065009 ! regulation of molecular function
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003824 ! catalytic activity
relationship: regulates GO:0003824 ! catalytic activity

[Term]
id: GO:0050792
name: regulation of viral process
namespace: biological_process
def: "Any process that modulates the rate or extent of the viral life cycle, the set of processes by which a virus reproduces and spreads among hosts." [GOC:go_curators, GOC:tb]
synonym: "regulation of viral life cycle" EXACT [GOC:tb]
synonym: "regulation of viral reproduction" NARROW [GOC:bf, GOC:jl]
is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016032 ! viral process
relationship: regulates GO:0016032 ! viral process

[Term]
id: GO:0050793
name: regulation of developmental process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032502 ! developmental process
relationship: regulates GO:0032502 ! developmental process

[Term]
id: GO:0050794
name: regulation of cellular process
namespace: biological_process
alt_id: GO:0051244
def: "Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of cellular physiological process" EXACT []
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009987 ! cellular process
relationship: regulates GO:0009987 ! cellular process

[Term]
id: GO:0050795
name: regulation of behavior
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." [GOC:go_curators, GOC:pr]
subset: gosubset_prok
synonym: "regulation of behaviour" EXACT []
is_a: GO:0048583 ! regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007610 ! behavior
relationship: regulates GO:0007610 ! behavior

[Term]
id: GO:0050796
name: regulation of insulin secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of insulin." [GOC:ai]
xref: Reactome:REACT_101597 "Regulation of Insulin Secretion, Xenopus tropicalis"
xref: Reactome:REACT_104758 "Incretin Synthesis, Secretion, and Inactivation, Mus musculus"
xref: Reactome:REACT_105869 "Regulation of Insulin Secretion, Taeniopygia guttata"
xref: Reactome:REACT_107553 "Incretin Synthesis, Secretion, and Inactivation, Sus scrofa"
xref: Reactome:REACT_108613 "Regulation of Insulin Secretion, Gallus gallus"
xref: Reactome:REACT_114254 "Regulation of Insulin Secretion, Oryza sativa"
xref: Reactome:REACT_114277 "Regulation of Insulin Secretion, Saccharomyces cerevisiae"
xref: Reactome:REACT_114911 "Regulation of Insulin Secretion, Arabidopsis thaliana"
xref: Reactome:REACT_115218 "Regulation of Insulin Secretion, Schizosaccharomyces pombe"
xref: Reactome:REACT_18325 "Regulation of Insulin Secretion, Homo sapiens"
xref: Reactome:REACT_23974 "Incretin Synthesis, Secretion, and Inactivation, Homo sapiens"
xref: Reactome:REACT_28774 "Regulation of Insulin Secretion, Canis familiaris"
xref: Reactome:REACT_30526 "Incretin Synthesis, Secretion, and Inactivation, Canis familiaris"
xref: Reactome:REACT_35721 "Regulation of Insulin Secretion, Dictyostelium discoideum"
xref: Reactome:REACT_82381 "Regulation of Insulin Secretion, Rattus norvegicus"
xref: Reactome:REACT_82648 "Incretin Synthesis, Secretion, and Inactivation, Bos taurus"
xref: Reactome:REACT_84459 "Regulation of Insulin Secretion, Bos taurus"
xref: Reactome:REACT_87602 "Regulation of Insulin Secretion, Drosophila melanogaster"
xref: Reactome:REACT_88056 "Regulation of Insulin Secretion, Mus musculus"
xref: Reactome:REACT_88814 "Regulation of Insulin Secretion, Caenorhabditis elegans"
xref: Reactome:REACT_89023 "Incretin Synthesis, Secretion, and Inactivation, Danio rerio"
xref: Reactome:REACT_90639 "Incretin Synthesis, Secretion, and Inactivation, Taeniopygia guttata"
xref: Reactome:REACT_92637 "Regulation of Insulin Secretion, Danio rerio"
xref: Reactome:REACT_94670 "Incretin Synthesis, Secretion, and Inactivation, Rattus norvegicus"
xref: Reactome:REACT_95188 "Regulation of Insulin Secretion, Sus scrofa"
xref: Reactome:REACT_96232 "Incretin Synthesis, Secretion, and Inactivation, Gallus gallus"
xref: Reactome:REACT_99834 "Incretin Synthesis, Secretion, and Inactivation, Xenopus tropicalis"
is_a: GO:0050708 ! regulation of protein secretion
is_a: GO:0090276 ! regulation of peptide hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030073 ! insulin secretion
relationship: regulates GO:0030073 ! insulin secretion

[Term]
id: GO:0050797
name: thymidylate synthase (FAD) activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP + NADPH + H+ = dTMP + tetrahydrofolate + NADP+." [EC:2.1.1.148]
subset: gosubset_prok
synonym: "5,10-methylenetetrahydrofolate,FADH2:dUMP C-methyltransferase activity" EXACT [EC:2.1.1.148]
synonym: "FDTS activity" EXACT [EC:2.1.1.148]
synonym: "flavin dependent thymidylate synthase activity" EXACT [EC:2.1.1.148]
synonym: "Thy1 activity" EXACT []
synonym: "ThyX activity" EXACT []
xref: EC:2.1.1.148
xref: KEGG:R06613
xref: MetaCyc:RXN-8850
xref: RHEA:29046
is_a: GO:0042083 ! 5,10-methylenetetrahydrofolate-dependent methyltransferase activity

[Term]
id: GO:0050798
name: activated T cell proliferation
namespace: biological_process
def: "The expansion of a T cell population following activation by an antigenic stimulus." [GOC:add, GOC:dph]
comment: Note that this term refers to the proliferation of previously activated T cells; it is to be used for gene products involved in T cell proliferation following an antigenic stimulus, including both proteins internal to the T cell and external factors, such as IL-2, which specifically promote proliferation of activated T cells.
synonym: "activated T lymphocyte proliferation" EXACT []
synonym: "activated T-cell proliferation" EXACT []
synonym: "activated T-lymphocyte proliferation" EXACT []
synonym: "proliferation of activated T cells" EXACT [GOC:mah]
is_a: GO:0042098 ! T cell proliferation

[Term]
id: GO:0050799
name: cocaine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cocaine, an alkaloid obtained from the dried leaves of the shrub Erythroxylon coca. It is a cerebral stimulant and narcotic." [GOC:ai]
subset: gosubset_prok
synonym: "cocaine anabolism" EXACT []
synonym: "cocaine biosynthesis" EXACT []
synonym: "cocaine formation" EXACT []
synonym: "cocaine synthesis" EXACT []
is_a: GO:0009710 ! tropane alkaloid biosynthetic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0050783 ! cocaine metabolic process

[Term]
id: GO:0050800
name: obsolete hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of GTP to directly drive the cellular or subcellular transport of a substance." [EC:3.6.5.-, GOC:ai]
comment: This term was made obsolete because it represents both process and function information.
synonym: "hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement" EXACT []
is_obsolete: true
consider: GO:0003924
consider: GO:0006810

[Term]
id: GO:0050801
name: ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of ions within an organism or cell." [GOC:ai]
subset: gosubset_prok
synonym: "electrolyte homeostasis" RELATED []
synonym: "negative regulation of crystal biosynthesis" RELATED []
synonym: "negative regulation of crystal formation" RELATED []
is_a: GO:0048878 ! chemical homeostasis

[Term]
id: GO:0050802
name: circadian sleep/wake cycle, sleep
namespace: biological_process
def: "The part of the circadian sleep/wake cycle where the organism is asleep." [GOC:ai]
is_a: GO:0022410 ! circadian sleep/wake cycle process
is_a: GO:0030431 ! sleep
is_a: GO:0044708 ! single-organism behavior
intersection_of: GO:0030431 ! sleep
intersection_of: part_of GO:0042745 ! circadian sleep/wake cycle
relationship: part_of GO:0042745 ! circadian sleep/wake cycle

[Term]
id: GO:0050803
name: regulation of synapse structure or activity
namespace: biological_process
def: "Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai]
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0050804
name: modulation of synaptic transmission
namespace: biological_process
def: "Any process that modulates the frequency or rate of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:ai]
synonym: "regulation of synaptic transmission" EXACT []
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0023051 ! regulation of signaling
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0007268 ! synaptic transmission
relationship: regulates GO:0007268 ! synaptic transmission

[Term]
id: GO:0050805
name: negative regulation of synaptic transmission
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:ai]
synonym: "down regulation of synaptic transmission" EXACT []
synonym: "down-regulation of synaptic transmission" EXACT []
synonym: "downregulation of synaptic transmission" EXACT []
synonym: "inhibition of synaptic transmission" NARROW []
is_a: GO:0010648 ! negative regulation of cell communication
is_a: GO:0023057 ! negative regulation of signaling
is_a: GO:0050804 ! modulation of synaptic transmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007268 ! synaptic transmission
relationship: negatively_regulates GO:0007268 ! synaptic transmission

[Term]
id: GO:0050806
name: positive regulation of synaptic transmission
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:ai]
synonym: "activation of synaptic transmission" NARROW []
synonym: "stimulation of synaptic transmission" NARROW []
synonym: "up regulation of synaptic transmission" EXACT []
synonym: "up-regulation of synaptic transmission" EXACT []
synonym: "upregulation of synaptic transmission" EXACT []
is_a: GO:0010647 ! positive regulation of cell communication
is_a: GO:0023056 ! positive regulation of signaling
is_a: GO:0050804 ! modulation of synaptic transmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007268 ! synaptic transmission
relationship: positively_regulates GO:0007268 ! synaptic transmission

[Term]
id: GO:0050807
name: regulation of synapse organization
namespace: biological_process
def: "Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:dph, GOC:tb]
synonym: "regulation of synapse organisation" EXACT [GOC:mah]
synonym: "regulation of synapse organization and biogenesis" RELATED [GOC:mah]
synonym: "regulation of synapse structure" EXACT []
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050808 ! synapse organization
relationship: part_of GO:0050803 ! regulation of synapse structure or activity
relationship: regulates GO:0050808 ! synapse organization

[Term]
id: GO:0050808
name: synapse organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr]
subset: goslim_synapse
synonym: "synapse development" EXACT []
synonym: "synapse morphogenesis" RELATED [GOC:BHF]
synonym: "synapse organisation" EXACT [GOC:curators]
synonym: "synapse organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0016043 ! cellular component organization
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0050809
name: diazepam binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with diazepam, one of the most widely used benzodiazepine drugs. It is used as an anti-anxiety-hypnotic agent and has the proprietary name Valium." [ISBN:0198506732]
synonym: "diazepam binding inhibitor activity" RELATED []
synonym: "Valium binding" EXACT []
is_a: GO:0008144 ! drug binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding

[Term]
id: GO:0050810
name: regulation of steroid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:ai]
subset: gosubset_prok
synonym: "regulation of steroid anabolism" EXACT []
synonym: "regulation of steroid biosynthesis" EXACT []
synonym: "regulation of steroid formation" EXACT []
synonym: "regulation of steroid synthesis" EXACT []
synonym: "regulation of steroidogenesis" EXACT []
is_a: GO:0019218 ! regulation of steroid metabolic process
is_a: GO:0046890 ! regulation of lipid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006694 ! steroid biosynthetic process
relationship: regulates GO:0006694 ! steroid biosynthetic process

[Term]
id: GO:0050811
name: GABA receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the gamma-aminobutyric acid (GABA, 4-aminobutyrate) receptor." [GOC:ai]
synonym: "4-aminobutanoate receptor binding" EXACT []
synonym: "4-aminobutyrate receptor binding" EXACT []
synonym: "diazepam binding inhibitor activity" RELATED []
synonym: "gamma-aminobutyric acid receptor binding" EXACT []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0050812
name: regulation of acyl-CoA biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acyl-CoA." [GOC:ai]
subset: gosubset_prok
synonym: "regulation of acyl-CoA anabolism" EXACT []
synonym: "regulation of acyl-CoA biosynthesis" EXACT []
synonym: "regulation of acyl-CoA formation" EXACT []
synonym: "regulation of acyl-CoA synthesis" EXACT []
is_a: GO:0019217 ! regulation of fatty acid metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
is_a: GO:0051174 ! regulation of phosphorus metabolic process
is_a: GO:0051196 ! regulation of coenzyme metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071616 ! acyl-CoA biosynthetic process
relationship: regulates GO:0071616 ! acyl-CoA biosynthetic process

[Term]
id: GO:0050813
name: epothilone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving epothilone, a drug obtained from the myxobacteria Sporangium cellulosum that interferes with cell division. Some epothilones are being studied as treatments for cancer." [http://www.onelook.com/, ISBN:0198506732]
subset: gosubset_prok
synonym: "epothilone metabolism" EXACT []
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0033067 ! macrolide metabolic process
is_a: GO:0042180 ! cellular ketone metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process

[Term]
id: GO:0050814
name: epothilone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of epothilone, a drug obtained from the myxobacteria Sporangium cellulosum that interferes with cell division. Some epothilones are being studied as treatments for cancer." [GOC:ai]
subset: gosubset_prok
synonym: "epothilone anabolism" EXACT []
synonym: "epothilone biosynthesis" EXACT []
synonym: "epothilone formation" EXACT []
synonym: "epothilone synthesis" EXACT []
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0033068 ! macrolide biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:0050813 ! epothilone metabolic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process

[Term]
id: GO:0050815
name: phosphoserine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a phosphorylated serine residue within a protein." [GOC:ai]
synonym: "phosphoserine/phosphothreonine binding" BROAD []
is_a: GO:0016597 ! amino acid binding
is_a: GO:0045309 ! protein phosphorylated amino acid binding

[Term]
id: GO:0050816
name: phosphothreonine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a phosphorylated threonine residue within a protein." [GOC:ai]
synonym: "phosphoserine/phosphothreonine binding" BROAD []
is_a: GO:0045309 ! protein phosphorylated amino acid binding

[Term]
id: GO:0050817
name: coagulation
namespace: biological_process
def: "The process in which a fluid solution, or part of it, changes into a solid or semisolid mass." [ISBN:0198506732]
subset: goslim_pir
synonym: "clotting" EXACT []
is_a: GO:0044707 ! single-multicellular organism process

[Term]
id: GO:0050818
name: regulation of coagulation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of coagulation, the process in which a fluid solution, or part of it, changes into a solid or semisolid mass." [GOC:ai]
synonym: "regulation of clotting" EXACT []
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050817 ! coagulation
relationship: regulates GO:0050817 ! coagulation

[Term]
id: GO:0050819
name: negative regulation of coagulation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of coagulation." [GOC:ai]
synonym: "anticoagulant activity" RELATED []
synonym: "down regulation of coagulation" EXACT []
synonym: "down-regulation of coagulation" EXACT []
synonym: "downregulation of coagulation" EXACT []
synonym: "inhibition of coagulation" NARROW []
synonym: "negative regulation of clotting." EXACT []
is_a: GO:0050818 ! regulation of coagulation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0050817 ! coagulation
relationship: negatively_regulates GO:0050817 ! coagulation

[Term]
id: GO:0050820
name: positive regulation of coagulation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of coagulation." [GOC:ai]
synonym: "activation of coagulation" NARROW []
synonym: "positive regulation of clotting" EXACT []
synonym: "stimulation of coagulation" NARROW []
synonym: "up regulation of coagulation" EXACT []
synonym: "up-regulation of coagulation" EXACT []
synonym: "upregulation of coagulation" EXACT []
is_a: GO:0050818 ! regulation of coagulation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0050817 ! coagulation
relationship: positively_regulates GO:0050817 ! coagulation

[Term]
id: GO:0050821
name: protein stabilization
namespace: biological_process
def: "Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai]
subset: goslim_chembl
subset: gosubset_prok
synonym: "lysosomal protein stabilization" NARROW []
synonym: "positive regulation of protein stability" EXACT []
synonym: "protein sequestering" RELATED []
synonym: "protein stabilisation" EXACT [GOC:ah]
synonym: "protein stabilization activity" RELATED []
is_a: GO:0031647 ! regulation of protein stability

[Term]
id: GO:0050822
name: peptide stabilization
namespace: biological_process
def: "Any process involved in maintaining the structure and integrity of a peptide and preventing it from being degraded." [GOC:ai]
subset: gosubset_prok
synonym: "peptide stabilisation" EXACT [GOC:ah]
synonym: "peptide stabilization activity" RELATED []
is_a: GO:0006518 ! peptide metabolic process

[Term]
id: GO:0050823
name: peptide antigen stabilization
namespace: biological_process
def: "Any process involved in maintaining the structure and integrity of a peptide antigen and preventing it from being degraded." [GOC:ai]
subset: gosubset_prok
synonym: "peptide antigen stabilization activity" RELATED []
is_a: GO:0050822 ! peptide stabilization
relationship: part_of GO:0048002 ! antigen processing and presentation of peptide antigen

[Term]
id: GO:0050824
name: water binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with water (H2O)." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0050825
name: ice binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal." [GOC:curators]
subset: gosubset_prok
synonym: "antifreeze activity" RELATED []
synonym: "ice crystal binding" EXACT []
synonym: "ice nucleation activity" RELATED []
synonym: "ice nucleation inhibitor activity" RELATED []
is_a: GO:0050824 ! water binding

[Term]
id: GO:0050826
name: response to freezing
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius." [GOC:jl]
subset: gosubset_prok
synonym: "antifreeze activity" RELATED []
synonym: "ice nucleation inhibitor activity" RELATED []
is_a: GO:0009409 ! response to cold

[Term]
id: GO:0050827
name: toxin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a toxin receptor, a receptor for substances that cause injury to living organisms." [GOC:ai]
synonym: "channel-forming toxin activity" RELATED []
synonym: "cytotoxin activity" RELATED []
synonym: "endotoxin activity" RELATED []
synonym: "enterotoxin activity" RELATED []
synonym: "exotoxin activity" RELATED []
synonym: "lipoprotein toxin" RELATED []
synonym: "neurotoxin activity" RELATED []
synonym: "pore-forming toxin activity" RELATED []
synonym: "toxin activity" RELATED []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0050828
name: regulation of liquid surface tension
namespace: biological_process
def: "Any process that modulates the surface tension of a liquid. Surface tension is the property that makes a liquid behave as if it had an elastic skin on its surface at the interface with a gas or an immiscible liquid." [ISBN:0198506732]
synonym: "regulation of surface tension of a liquid" EXACT []
synonym: "surfactant activity" RELATED []
is_a: GO:0042592 ! homeostatic process

[Term]
id: GO:0050829
name: defense response to Gram-negative bacterium
namespace: biological_process
def: "Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
synonym: "defence response to Gram-negative bacteria" EXACT []
synonym: "defence response to Gram-negative bacterium" EXACT []
synonym: "defense response to Gram-negative bacteria" EXACT []
synonym: "Gram-negative antibacterial peptide activity" RELATED []
is_a: GO:0042742 ! defense response to bacterium

[Term]
id: GO:0050830
name: defense response to Gram-positive bacterium
namespace: biological_process
def: "Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism." [GOC:ai]
subset: gosubset_prok
synonym: "defence response to Gram-positive bacteria" EXACT []
synonym: "defence response to Gram-positive bacterium" EXACT []
synonym: "defense response to Gram-positive bacteria" EXACT []
synonym: "Gram-positive antibacterial peptide activity" RELATED []
is_a: GO:0042742 ! defense response to bacterium

[Term]
id: GO:0050831
name: male-specific defense response to bacterium
namespace: biological_process
def: "A set of reactions, specific to males, that are triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:ai]
synonym: "male-specific antibacterial peptide activity" RELATED []
synonym: "male-specific defence response to bacteria" EXACT []
synonym: "male-specific defence response to bacterium" EXACT []
synonym: "male-specific defense response to bacteria" EXACT []
is_a: GO:0042742 ! defense response to bacterium

[Term]
id: GO:0050832
name: defense response to fungus
namespace: biological_process
alt_id: GO:0042831
def: "Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai]
synonym: "defence response to fungi" EXACT []
synonym: "defence response to fungus" EXACT []
synonym: "defense response to fungi" EXACT []
is_a: GO:0009620 ! response to fungus
is_a: GO:0098542 ! defense response to other organism

[Term]
id: GO:0050833
name: pyruvate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of pyruvate, 2-oxopropanoate, from one side of the membrane to the other." [GOC:ai]
synonym: "monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity" RELATED []
xref: Reactome:REACT_116055 "pyruvate + H+ [cytosol] => pyruvate + H+ [mitochondrial matrix], Gallus gallus"
xref: Reactome:REACT_14789 "pyruvate + H+ [cytosol] => pyruvate + H+ [mitochondrial matrix], Rattus norvegicus"
xref: Reactome:REACT_14833 "pyruvate + H+ [cytosol] => pyruvate + H+ [mitochondrial matrix], Homo sapiens"
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
relationship: part_of GO:1901475 ! pyruvate transmembrane transport

[Term]
id: GO:0050834
name: molybdenum incorporation via L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide
namespace: biological_process
def: "The incorporation of molybdenum into a protein by L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide." [RESID:AA0355]
subset: gosubset_prok
xref: RESID:AA0355
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018315 ! molybdenum incorporation into molybdenum-molybdopterin complex

[Term]
id: GO:0050835
name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl S-adenosylmethion-N,O-diyl tetrairon tetrasulfide
namespace: biological_process
def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl S-adenosylmethion-N,O-diyl tetrairon tetrasulfide." [RESID:AA0356]
subset: gosubset_prok
xref: RESID:AA0356
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:0050843 ! S-adenosylmethionine catabolic process

[Term]
id: GO:0050836
name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl L-arginyl diiron disulfide
namespace: biological_process
def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl L-arginyl diiron disulfide." [RESID:AA0357]
subset: gosubset_prok
xref: RESID:AA0357
is_a: GO:0018195 ! peptidyl-arginine modification
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0050837
name: peptide cross-linking via L-cysteinyl-L-selenocysteine
namespace: biological_process
def: "The formation of a selenide-sulfide bond to form the cystine-like L-cysteinyl-L-selenocysteine, as in vertebrate selenopeptide P." [RESID:AA0358]
subset: gosubset_prok
xref: RESID:AA0358
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0050844 ! peptidyl-selenocysteine modification

[Term]
id: GO:0050838
name: peptidyl-5-hydroxy-L-lysine trimethylation
namespace: biological_process
def: "The methylation of 5-hydroxy-L-lysine to form peptidyl-N6,N6,N6-trimethyl-5-hydroxy-L-lysine." [RESID:AA0359]
subset: gosubset_prok
xref: RESID:AA0359
is_a: GO:0018022 ! peptidyl-lysine methylation

[Term]
id: GO:0050839
name: cell adhesion molecule binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a cell adhesion molecule." [GOC:ai]
synonym: "adhesive extracellular matrix constituent" RELATED []
synonym: "CAM binding" EXACT []
synonym: "cell adhesion molecule activity" RELATED []
synonym: "cell adhesion receptor activity" RELATED []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0050840
name: extracellular matrix binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a component of the extracellular matrix." [GOC:ai]
subset: goslim_chembl
subset: goslim_pir
subset: gosubset_prok
synonym: "adhesive extracellular matrix constituent" RELATED []
synonym: "extracellular matrix constituent binding" EXACT []
is_a: GO:0005488 ! binding

[Term]
id: GO:0050841
name: peptidyl-N6,N6,N6-trimethyl-lysine hydroxylation to peptidyl-N6,N6,N6-trimethyl-5-hydroxy-L-lysine
namespace: biological_process
def: "The hydroxylation of peptidyl-N6,N6,N6-trimethyl-L-lysine to form peptidyl-N6,N6,N6-trimethyl-5-hydroxy-L-lysine." [RESID:AA0359]
subset: gosubset_prok
synonym: "peptidyl trimethyl lysine hydroxylase activity" EXACT []
synonym: "peptidyl-trimethyl-lysine hydroxylase activity" EXACT []
xref: RESID:AA0359
is_a: GO:0017185 ! peptidyl-lysine hydroxylation

[Term]
id: GO:0050842
name: copper incorporation via L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide
namespace: biological_process
def: "The incorporation of copper into a protein by L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide." [RESID:AA0355]
subset: gosubset_prok
xref: RESID:AA0355
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018427 ! copper incorporation into metallo-sulfur cluster

[Term]
id: GO:0050843
name: S-adenosylmethionine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism." [GOC:ai]
subset: gosubset_prok
synonym: "S-adenosyl methionine catabolic process" EXACT []
synonym: "S-adenosyl methionine catabolism" EXACT []
synonym: "S-adenosylmethionine breakdown" EXACT []
synonym: "S-adenosylmethionine catabolism" EXACT []
synonym: "S-adenosylmethionine degradation" EXACT []
synonym: "SAM catabolic process" EXACT []
is_a: GO:0009109 ! coenzyme catabolic process
is_a: GO:0042219 ! cellular modified amino acid catabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0046130 ! purine ribonucleoside catabolic process
is_a: GO:0046500 ! S-adenosylmethionine metabolic process

[Term]
id: GO:0050844
name: peptidyl-selenocysteine modification
namespace: biological_process
def: "The modification of peptidyl-selenocysteine." [GOC:ai]
subset: gosubset_prok
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0050845
name: teichuronic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of teichuronic acid, a polymer containing chains of uronic acids and N-acetylglucosamine found in the cell wall, membrane or capsule of Gram-positive bacteria." [ISBN:0815108893]
subset: gosubset_prok
synonym: "teichuronic acid anabolism" EXACT []
synonym: "teichuronic acid biosynthesis" EXACT []
synonym: "teichuronic acid formation" EXACT []
synonym: "teichuronic acid synthesis" EXACT []
is_a: GO:0016053 ! organic acid biosynthetic process
is_a: GO:0044038 ! cell wall macromolecule biosynthetic process
is_a: GO:0050846 ! teichuronic acid metabolic process
relationship: part_of GO:0009273 ! peptidoglycan-based cell wall biogenesis

[Term]
id: GO:0050846
name: teichuronic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving teichuronic acid, a polymer containing chains of uronic acids and N-acetylglucosamine found in the cell wall, membrane or capsule of Gram-positive bacteria." [ISBN:0815108893]
subset: gosubset_prok
synonym: "teichuronic acid metabolism" EXACT []
is_a: GO:0006082 ! organic acid metabolic process

[Term]
id: GO:0050847
name: progesterone receptor signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of a progesterone binding to its receptor." [GOC:ai, GOC:mah, PMID:14744870]
synonym: "progesterone receptor signalling pathway" EXACT []
is_a: GO:0030518 ! intracellular steroid hormone receptor signaling pathway

[Term]
id: GO:0050848
name: regulation of calcium-mediated signaling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of calcium-mediated signaling, the process in which a cell uses calcium ions to convert an extracellular signal into a response." [GOC:ai]
synonym: "regulation of calcium-mediated signalling" EXACT []
is_a: GO:1902531 ! regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019722 ! calcium-mediated signaling
relationship: regulates GO:0019722 ! calcium-mediated signaling

[Term]
id: GO:0050849
name: negative regulation of calcium-mediated signaling
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of calcium-mediated signaling." [GOC:ai, PMID:11696592]
synonym: "down regulation of calcium-mediated signaling" EXACT []
synonym: "down-regulation of calcium-mediated signaling" EXACT []
synonym: "downregulation of calcium-mediated signaling" EXACT []
synonym: "inhibition of calcium-mediated signaling" NARROW []
synonym: "negative regulation of calcium-mediated signalling" EXACT []
is_a: GO:0050848 ! regulation of calcium-mediated signaling
is_a: GO:1902532 ! negative regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019722 ! calcium-mediated signaling
relationship: negatively_regulates GO:0019722 ! calcium-mediated signaling

[Term]
id: GO:0050850
name: positive regulation of calcium-mediated signaling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of calcium-mediated signaling." [GOC:ai]
synonym: "activation of calcium-mediated signaling" NARROW []
synonym: "positive regulation of calcium-mediated signalling" EXACT []
synonym: "stimulation of calcium-mediated signaling" NARROW []
synonym: "up regulation of calcium-mediated signaling" EXACT []
synonym: "up-regulation of calcium-mediated signaling" EXACT []
synonym: "upregulation of calcium-mediated signaling" EXACT []
is_a: GO:0050848 ! regulation of calcium-mediated signaling
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0019722 ! calcium-mediated signaling
relationship: positively_regulates GO:0019722 ! calcium-mediated signaling

[Term]
id: GO:0050851
name: antigen receptor-mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the cross-linking of an antigen receptor on a B or T cell." [GOC:add]
synonym: "antigen receptor-mediated signalling pathway" EXACT []
is_a: GO:0002429 ! immune response-activating cell surface receptor signaling pathway

[Term]
id: GO:0050852
name: T cell receptor signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell." [GOC:add]
synonym: "T lymphocyte receptor signaling pathway" EXACT []
synonym: "T lymphocyte receptor signalling pathway" EXACT []
synonym: "T-cell receptor signaling pathway" EXACT []
synonym: "T-cell receptor signalling pathway" EXACT []
synonym: "T-lymphocyte receptor signaling pathway" EXACT []
synonym: "T-lymphocyte receptor signalling pathway" EXACT []
synonym: "TCR signaling pathway" EXACT []
xref: Reactome:REACT_102534 "TCR signaling, Gallus gallus"
xref: Reactome:REACT_102907 "TCR signaling, Arabidopsis thaliana"
xref: Reactome:REACT_103838 "TCR signaling, Taeniopygia guttata"
xref: Reactome:REACT_106959 "TCR signaling, Canis familiaris"
xref: Reactome:REACT_109039 "TCR signaling, Mus musculus"
xref: Reactome:REACT_110226 "TCR signaling, Rattus norvegicus"
xref: Reactome:REACT_112881 "TCR signaling, Plasmodium falciparum"
xref: Reactome:REACT_12526 "TCR signaling, Homo sapiens"
xref: Reactome:REACT_29560 "TCR signaling, Oryza sativa"
xref: Reactome:REACT_30398 "TCR signaling, Bos taurus"
xref: Reactome:REACT_31031 "TCR signaling, Drosophila melanogaster"
xref: Reactome:REACT_33984 "TCR signaling, Xenopus tropicalis"
xref: Reactome:REACT_85467 "TCR signaling, Sus scrofa"
xref: Reactome:REACT_87508 "TCR signaling, Schizosaccharomyces pombe"
xref: Reactome:REACT_88130 "TCR signaling, Dictyostelium discoideum"
xref: Reactome:REACT_89628 "TCR signaling, Caenorhabditis elegans"
xref: Reactome:REACT_96029 "TCR signaling, Saccharomyces cerevisiae"
xref: Reactome:REACT_96807 "TCR signaling, Danio rerio"
is_a: GO:0050851 ! antigen receptor-mediated signaling pathway

[Term]
id: GO:0050853
name: B cell receptor signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell." [GOC:add]
synonym: "B cell receptor signalling pathway" EXACT []
synonym: "B lymphocyte receptor signaling pathway" EXACT []
synonym: "B lymphocyte receptor signalling pathway" EXACT []
synonym: "B-cell receptor signaling pathway" EXACT []
synonym: "B-cell receptor signalling pathway" EXACT []
synonym: "B-lymphocyte receptor signaling pathway" EXACT []
synonym: "B-lymphocyte receptor signalling pathway" EXACT []
is_a: GO:0050851 ! antigen receptor-mediated signaling pathway

[Term]
id: GO:0050854
name: regulation of antigen receptor-mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell." [GOC:ai]
synonym: "regulation of antigen receptor mediated signalling pathway" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0050776 ! regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050851 ! antigen receptor-mediated signaling pathway
relationship: regulates GO:0050851 ! antigen receptor-mediated signaling pathway

[Term]
id: GO:0050855
name: regulation of B cell receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell." [GOC:ai]
synonym: "regulation of B cell receptor signalling pathway" EXACT []
synonym: "regulation of B lymphocyte receptor signaling pathway" EXACT []
synonym: "regulation of B lymphocyte receptor signalling pathway" EXACT []
synonym: "regulation of B-cell receptor signaling pathway" EXACT []
synonym: "regulation of B-cell receptor signalling pathway" EXACT []
synonym: "regulation of B-lymphocyte receptor signaling pathway" EXACT []
synonym: "regulation of B-lymphocyte receptor signalling pathway" EXACT []
is_a: GO:0050854 ! regulation of antigen receptor-mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050853 ! B cell receptor signaling pathway
relationship: regulates GO:0050853 ! B cell receptor signaling pathway

[Term]
id: GO:0050856
name: regulation of T cell receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell." [GOC:ai]
synonym: "regulation of T lymphocyte receptor signaling pathway" EXACT []
synonym: "regulation of T lymphocyte receptor signalling pathway" EXACT []
synonym: "regulation of T-cell receptor signaling pathway" EXACT []
synonym: "regulation of T-cell receptor signalling pathway" EXACT []
synonym: "regulation of T-lymphocyte receptor signaling pathway" EXACT []
synonym: "regulation of T-lymphocyte receptor signalling pathway" EXACT []
synonym: "regulation of TCR signaling pathway" EXACT []
is_a: GO:0050854 ! regulation of antigen receptor-mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050852 ! T cell receptor signaling pathway
relationship: regulates GO:0050852 ! T cell receptor signaling pathway

[Term]
id: GO:0050857
name: positive regulation of antigen receptor-mediated signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell." [GOC:ai]
synonym: "activation of antigen receptor-mediated signaling pathway" NARROW []
synonym: "positive regulation of antigen receptor mediated signalling pathway" EXACT []
synonym: "stimulation of antigen receptor-mediated signaling pathway" NARROW []
synonym: "up regulation of antigen receptor-mediated signaling pathway" EXACT []
synonym: "up-regulation of antigen receptor-mediated signaling pathway" EXACT []
synonym: "upregulation of antigen receptor-mediated signaling pathway" EXACT []
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0050854 ! regulation of antigen receptor-mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0050851 ! antigen receptor-mediated signaling pathway
relationship: positively_regulates GO:0050851 ! antigen receptor-mediated signaling pathway

[Term]
id: GO:0050858
name: negative regulation of antigen receptor-mediated signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell." [GOC:ai]
synonym: "down regulation of antigen receptor-mediated signaling pathway" EXACT []
synonym: "down-regulation of antigen receptor-mediated signaling pathway" EXACT []
synonym: "downregulation of antigen receptor-mediated signaling pathway" EXACT []
synonym: "inhibition of antigen receptor-mediated signaling pathway" NARROW []
synonym: "negative regulation of antigen receptor mediated signalling pathway" EXACT []
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0050854 ! regulation of antigen receptor-mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0050851 ! antigen receptor-mediated signaling pathway
relationship: negatively_regulates GO:0050851 ! antigen receptor-mediated signaling pathway

[Term]
id: GO:0050859
name: negative regulation of B cell receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell." [GOC:ai]
synonym: "down regulation of B cell receptor signaling pathway" EXACT []
synonym: "down-regulation of B cell receptor signaling pathway" EXACT []
synonym: "downregulation of B cell receptor signaling pathway" EXACT []
synonym: "inhibition of B cell receptor signaling pathway" NARROW []
synonym: "negative regulation of B cell receptor signalling pathway" EXACT []
synonym: "negative regulation of B lymphocyte receptor signaling pathway" EXACT []
synonym: "negative regulation of B lymphocyte receptor signalling pathway" EXACT []
synonym: "negative regulation of B-cell receptor signaling pathway" EXACT []
synonym: "negative regulation of B-cell receptor signalling pathway" EXACT []
synonym: "negative regulation of B-lymphocyte receptor signaling pathway" EXACT []
synonym: "negative regulation of B-lymphocyte receptor signalling pathway" EXACT []
is_a: GO:0050855 ! regulation of B cell receptor signaling pathway
is_a: GO:0050858 ! negative regulation of antigen receptor-mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0050853 ! B cell receptor signaling pathway
relationship: negatively_regulates GO:0050853 ! B cell receptor signaling pathway

[Term]
id: GO:0050860
name: negative regulation of T cell receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell." [GOC:ai]
synonym: "down regulation of T cell receptor signaling pathway" EXACT []
synonym: "down-regulation of T cell receptor signaling pathway" EXACT []
synonym: "downregulation of T cell receptor signaling pathway" EXACT []
synonym: "inhibition of T cell receptor signaling pathway" NARROW []
synonym: "negative regulation of T cell receptor signalling pathway" EXACT []
synonym: "negative regulation of T lymphocyte receptor signaling pathway" EXACT []
synonym: "negative regulation of T lymphocyte receptor signalling pathway" EXACT []
synonym: "negative regulation of T-cell receptor signaling pathway" EXACT []
synonym: "negative regulation of T-lymphocyte receptor signaling pathway" EXACT []
synonym: "negative regulation of T-lymphocyte receptor signalling pathway" EXACT []
synonym: "negative regulation of TCR signaling pathway" EXACT []
is_a: GO:0050856 ! regulation of T cell receptor signaling pathway
is_a: GO:0050858 ! negative regulation of antigen receptor-mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0050852 ! T cell receptor signaling pathway
relationship: negatively_regulates GO:0050852 ! T cell receptor signaling pathway

[Term]
id: GO:0050861
name: positive regulation of B cell receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell." [GOC:ai]
synonym: "activation of B cell receptor signaling pathway" NARROW []
synonym: "positive regulation of B cell receptor signalling pathway" EXACT []
synonym: "positive regulation of B lymphocyte receptor signaling pathway" EXACT []
synonym: "positive regulation of B lymphocyte receptor signalling pathway" EXACT []
synonym: "positive regulation of B-cell receptor signaling pathway" EXACT []
synonym: "positive regulation of B-cell receptor signalling pathway" EXACT []
synonym: "positive regulation of B-lymphocyte receptor signaling pathway" EXACT []
synonym: "positive regulation of B-lymphocyte receptor signalling pathway" EXACT []
synonym: "stimulation of B cell receptor signaling pathway" NARROW []
synonym: "up regulation of B cell receptor signaling pathway" EXACT []
synonym: "up-regulation of B cell receptor signaling pathway" EXACT []
synonym: "upregulation of B cell receptor signaling pathway" EXACT []
is_a: GO:0050855 ! regulation of B cell receptor signaling pathway
is_a: GO:0050857 ! positive regulation of antigen receptor-mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0050853 ! B cell receptor signaling pathway
relationship: positively_regulates GO:0050853 ! B cell receptor signaling pathway

[Term]
id: GO:0050862
name: positive regulation of T cell receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell." [GOC:ai]
synonym: "activation of T cell receptor signaling pathway" NARROW []
synonym: "positive regulation of T cell receptor signalling pathway" EXACT []
synonym: "positive regulation of T lymphocyte receptor signaling pathway" EXACT []
synonym: "positive regulation of T lymphocyte receptor signalling pathway" EXACT []
synonym: "positive regulation of T-cell receptor signaling pathway" EXACT []
synonym: "positive regulation of T-lymphocyte receptor signaling pathway" EXACT []
synonym: "positive regulation of T-lymphocyte receptor signalling pathway" EXACT []
synonym: "positive regulation of TCR signaling pathway" EXACT []
synonym: "stimulation of T cell receptor signaling pathway" NARROW []
synonym: "up regulation of T cell receptor signaling pathway" EXACT []
synonym: "up-regulation of T cell receptor signaling pathway" EXACT []
synonym: "upregulation of T cell receptor signaling pathway" EXACT []
is_a: GO:0050856 ! regulation of T cell receptor signaling pathway
is_a: GO:0050857 ! positive regulation of antigen receptor-mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0050852 ! T cell receptor signaling pathway
relationship: positively_regulates GO:0050852 ! T cell receptor signaling pathway

[Term]
id: GO:0050863
name: regulation of T cell activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of T cell activation." [GOC:ai]
synonym: "regulation of T lymphocyte activation" EXACT []
synonym: "regulation of T-cell activation" EXACT []
synonym: "regulation of T-lymphocyte activation" EXACT []
is_a: GO:0034110 ! regulation of homotypic cell-cell adhesion
is_a: GO:0051249 ! regulation of lymphocyte activation
is_a: GO:1903037 ! regulation of leukocyte cell-cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042110 ! T cell activation
relationship: regulates GO:0042110 ! T cell activation

[Term]
id: GO:0050864
name: regulation of B cell activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of B cell activation." [GOC:ai]
synonym: "regulation of B lymphocyte activation" EXACT []
synonym: "regulation of B-cell activation" EXACT []
synonym: "regulation of B-lymphocyte activation" EXACT []
is_a: GO:0051249 ! regulation of lymphocyte activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042113 ! B cell activation
relationship: regulates GO:0042113 ! B cell activation

[Term]
id: GO:0050865
name: regulation of cell activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell activation, the change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:ai]
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001775 ! cell activation
relationship: regulates GO:0001775 ! cell activation

[Term]
id: GO:0050866
name: negative regulation of cell activation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell activation." [GOC:ai]
synonym: "down regulation of cell activation" EXACT []
synonym: "down-regulation of cell activation" EXACT []
synonym: "downregulation of cell activation" EXACT []
synonym: "inhibition of cell activation" NARROW []
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0050865 ! regulation of cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001775 ! cell activation
relationship: negatively_regulates GO:0001775 ! cell activation

[Term]
id: GO:0050867
name: positive regulation of cell activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of activation." [GOC:ai]
synonym: "activation of cell activation" NARROW []
synonym: "stimulation of cell activation" NARROW []
synonym: "up regulation of cell activation" EXACT []
synonym: "up-regulation of cell activation" EXACT []
synonym: "upregulation of cell activation" EXACT []
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0050865 ! regulation of cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001775 ! cell activation
relationship: positively_regulates GO:0001775 ! cell activation

[Term]
id: GO:0050868
name: negative regulation of T cell activation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell activation." [GOC:ai]
synonym: "down regulation of T cell activation" EXACT []
synonym: "down-regulation of T cell activation" EXACT []
synonym: "downregulation of T cell activation" EXACT []
synonym: "inhibition of T cell activation" NARROW []
synonym: "negative regulation of T lymphocyte activation" EXACT []
synonym: "negative regulation of T-cell activation" EXACT []
synonym: "negative regulation of T-lymphocyte activation" EXACT []
is_a: GO:0034111 ! negative regulation of homotypic cell-cell adhesion
is_a: GO:0050863 ! regulation of T cell activation
is_a: GO:0051250 ! negative regulation of lymphocyte activation
is_a: GO:1903038 ! negative regulation of leukocyte cell-cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042110 ! T cell activation
relationship: negatively_regulates GO:0042110 ! T cell activation

[Term]
id: GO:0050869
name: negative regulation of B cell activation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of B cell activation." [GOC:ai]
synonym: "down regulation of B cell activation" EXACT []
synonym: "down-regulation of B cell activation" EXACT []
synonym: "downregulation of B cell activation" EXACT []
synonym: "inhibition of B cell activation" NARROW []
synonym: "negative regulation of B lymphocyte activation" EXACT []
synonym: "negative regulation of B-cell activation" EXACT []
synonym: "negative regulation of B-lymphocyte activation" EXACT []
is_a: GO:0050864 ! regulation of B cell activation
is_a: GO:0051250 ! negative regulation of lymphocyte activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042113 ! B cell activation
relationship: negatively_regulates GO:0042113 ! B cell activation

[Term]
id: GO:0050870
name: positive regulation of T cell activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T cell activation." [GOC:ai]
synonym: "activation of T cell activation" NARROW []
synonym: "positive regulation of T lymphocyte activation" EXACT []
synonym: "positive regulation of T-cell activation" EXACT []
synonym: "positive regulation of T-lymphocyte activation" EXACT []
synonym: "stimulation of T cell activation" NARROW []
synonym: "up regulation of T cell activation" EXACT []
synonym: "up-regulation of T cell activation" EXACT []
synonym: "upregulation of T cell activation" EXACT []
is_a: GO:0034112 ! positive regulation of homotypic cell-cell adhesion
is_a: GO:0050863 ! regulation of T cell activation
is_a: GO:0051251 ! positive regulation of lymphocyte activation
is_a: GO:1903039 ! positive regulation of leukocyte cell-cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042110 ! T cell activation
relationship: positively_regulates GO:0042110 ! T cell activation

[Term]
id: GO:0050871
name: positive regulation of B cell activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of B cell activation." [GOC:ai]
synonym: "activation of B cell activation" NARROW []
synonym: "positive regulation of B lymphocyte activation" EXACT []
synonym: "positive regulation of B-cell activation" EXACT []
synonym: "positive regulation of B-lymphocyte activation" EXACT []
synonym: "stimulation of B cell activation" NARROW []
synonym: "up regulation of B cell activation" EXACT []
synonym: "up-regulation of B cell activation" EXACT []
synonym: "upregulation of B cell activation" EXACT []
is_a: GO:0050864 ! regulation of B cell activation
is_a: GO:0051251 ! positive regulation of lymphocyte activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042113 ! B cell activation
relationship: positively_regulates GO:0042113 ! B cell activation

[Term]
id: GO:0050872
name: white fat cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a white adipocyte, an animal connective tissue cell involved in energy storage. White adipocytes have cytoplasmic lipids arranged in a unique vacuole." [PMID:12508945]
synonym: "white adipocyte cell differentiation" EXACT []
synonym: "white adipocyte differentiation" EXACT []
is_a: GO:0045444 ! fat cell differentiation

[Term]
id: GO:0050873
name: brown fat cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria." [PMID:12588810]
synonym: "brown adipocyte cell differentiation" EXACT []
synonym: "brown adipocyte differentiation" EXACT []
is_a: GO:0045444 ! fat cell differentiation

[Term]
id: GO:0050877
name: neurological system process
namespace: biological_process
def: "A organ system process carried out by any of the organs or tissues of neurological system." [GOC:ai, GOC:mtg_cardio]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_pir
synonym: "neurophysiological process" EXACT []
synonym: "pan-neural process" RELATED []
is_a: GO:0003008 ! system process

[Term]
id: GO:0050878
name: regulation of body fluid levels
namespace: biological_process
def: "Any process that modulates the levels of body fluids." [GOC:ai, GOC:dph, GOC:tb]
subset: goslim_pir
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0050879
name: multicellular organismal movement
namespace: biological_process
def: "Any physiological process involved in changing the position of a multicellular organism or an anatomical part of a multicellular organism." [GOC:dph, GOC:mtg_muscle, GOC:tb]
subset: goslim_pir
is_a: GO:0044707 ! single-multicellular organism process

[Term]
id: GO:0050880
name: regulation of blood vessel size
namespace: biological_process
def: "Any process that modulates the size of blood vessels." [GOC:ai]
is_a: GO:0003018 ! vascular process in circulatory system
is_a: GO:0035150 ! regulation of tube size
relationship: part_of GO:0008015 ! blood circulation

[Term]
id: GO:0050881
name: musculoskeletal movement
namespace: biological_process
def: "The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system." [GOC:dph]
is_a: GO:0050879 ! multicellular organismal movement

[Term]
id: GO:0050882
name: voluntary musculoskeletal movement
namespace: biological_process
def: "The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system that can be controlled at will." [GOC:dph]
is_a: GO:0050881 ! musculoskeletal movement

[Term]
id: GO:0050883
name: musculoskeletal movement, spinal reflex action
namespace: biological_process
def: "Involuntary movement caused by the application of a stimulus to an organism and a subsequent movement. The signal processing of this movement takes place in the spinal cord." [GOC:dph]
is_a: GO:0050881 ! musculoskeletal movement
is_a: GO:0060004 ! reflex

[Term]
id: GO:0050884
name: neuromuscular process controlling posture
namespace: biological_process
def: "Any process in which an organism voluntarily modulates its posture, the alignment of its anatomical parts." [GOC:dph, GOC:tb]
synonym: "regulation of posture" EXACT []
is_a: GO:0050905 ! neuromuscular process

[Term]
id: GO:0050885
name: neuromuscular process controlling balance
namespace: biological_process
def: "Any process that an organism uses to control its balance, the orientation of the organism (or the head of the organism) in relation to the source of gravity. In humans and animals, balance is perceived through visual cues, the labyrinth system of the inner ears and information from skin pressure receptors and muscle and joint receptors." [GOC:ai, GOC:dph, http://www.onelook.com/]
synonym: "regulation of balance" RELATED []
is_a: GO:0050905 ! neuromuscular process

[Term]
id: GO:0050886
name: endocrine process
namespace: biological_process
def: "The process that involves the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system." [ISBN:0721662544]
subset: goslim_pir
synonym: "endocrine physiological process" EXACT []
synonym: "endocrine physiology" EXACT []
is_a: GO:0003008 ! system process

[Term]
id: GO:0050887
name: determination of sensory modality
namespace: biological_process
def: "The determination of the type or quality of a sensation. Sensory modalities include touch, thermal sensation, visual sensation, auditory sensation and pain." [ISBN:0721619908]
is_a: GO:0050893 ! sensory processing

[Term]
id: GO:0050888
name: determination of stimulus location
namespace: biological_process
def: "The determination of where on the body surface, within the body or in the environment a stimulus originates." [ISBN:0721619908]
is_a: GO:0050893 ! sensory processing

[Term]
id: GO:0050889
name: determination of stimulus intensity
namespace: biological_process
def: "The determination of the perceived strength of a sensory stimulus." [ISBN:0721619908]
is_a: GO:0050893 ! sensory processing

[Term]
id: GO:0050890
name: cognition
namespace: biological_process
def: "The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory." [http://www.onelook.com/, ISBN:0721619908]
xref: Wikipedia:Cognition
is_a: GO:0050877 ! neurological system process

[Term]
id: GO:0050891
name: multicellular organismal water homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of water within a tissue, organ, or a multicellular organism." [GOC:dph, GOC:tb]
synonym: "body fluid osmoregulation" RELATED [GOC:dph, GOC:tb]
is_a: GO:0030104 ! water homeostasis
is_a: GO:0048871 ! multicellular organismal homeostasis
is_a: GO:0050878 ! regulation of body fluid levels

[Term]
id: GO:0050892
name: intestinal absorption
namespace: biological_process
def: "Any process in which nutrients are taken up from the contents of the intestine." [GOC:ai, GOC:dph]
is_a: GO:0022600 ! digestive system process
is_a: GO:0044707 ! single-multicellular organism process
is_a: GO:0044765 ! single-organism transport
relationship: part_of GO:0007586 ! digestion

[Term]
id: GO:0050893
name: sensory processing
namespace: biological_process
def: "Any neural process required for an organism to sense and interpret the dimensions of a sensory experience: modality, location, intensity and affect." [GOC:dph, ISBN:0721662544]
is_a: GO:0050890 ! cognition
relationship: part_of GO:0007600 ! sensory perception

[Term]
id: GO:0050894
name: determination of affect
namespace: biological_process
def: "Any process in which an emotional response is associated with a particular sensory stimulation." [GOC:ai, GOC:dph, ISBN:0721662544]
is_a: GO:0050893 ! sensory processing

[Term]
id: GO:0050896
name: response to stimulus
namespace: biological_process
alt_id: GO:0051869
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
subset: goslim_pir
subset: gosubset_prok
synonym: "physiological response to stimulus" EXACT []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0050897
name: cobalt ion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a cobalt (Co) ion." [GOC:ai]
subset: gosubset_prok
synonym: "cobalt binding" EXACT []
is_a: GO:0046914 ! transition metal ion binding

[Term]
id: GO:0050898
name: nitrile metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nitriles, an organic compound containing trivalent nitrogen attached to one carbon atom. The nitriles are named with reference to the acids produced by their decomposition; for example, hydrocyanic acid is formic nitrile, and methyl cyanide is acetic nitrile." [CHEBI:18379, GOC:curators, ISBN:0721662544]
subset: gosubset_prok
synonym: "nitrile metabolism" EXACT []
is_a: GO:1901564 ! organonitrogen compound metabolic process

[Term]
id: GO:0050899
name: nitrile catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a nitrile, an organic compound containing trivalent nitrogen attached to one carbon atom." [ISBN:0721662544]
subset: gosubset_prok
synonym: "nitrile breakdown" EXACT []
synonym: "nitrile catabolism" EXACT []
synonym: "nitrile degradation" EXACT []
is_a: GO:0044270 ! cellular nitrogen compound catabolic process
is_a: GO:0050898 ! nitrile metabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process

[Term]
id: GO:0050900
name: leukocyte migration
namespace: biological_process
def: "The movement of a leukocyte within or between different tissues and organs of the body." [GOC:add, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538]
synonym: "immune cell migration" EXACT []
synonym: "immune cell trafficking" EXACT []
synonym: "leucocyte migration" EXACT []
synonym: "leucocyte trafficking" EXACT []
synonym: "leukocyte trafficking" EXACT []
xref: Reactome:REACT_100059 "Cell surface interactions at the vascular wall, Sus scrofa"
xref: Reactome:REACT_12051 "Cell surface interactions at the vascular wall, Homo sapiens"
xref: Reactome:REACT_28425 "Cell surface interactions at the vascular wall, Bos taurus"
xref: Reactome:REACT_34071 "Cell surface interactions at the vascular wall, Xenopus tropicalis"
xref: Reactome:REACT_77198 "Cell surface interactions at the vascular wall, Taeniopygia guttata"
xref: Reactome:REACT_83057 "Cell surface interactions at the vascular wall, Danio rerio"
xref: Reactome:REACT_86476 "Cell surface interactions at the vascular wall, Canis familiaris"
xref: Reactome:REACT_86886 "Cell surface interactions at the vascular wall, Mus musculus"
xref: Reactome:REACT_89386 "Cell surface interactions at the vascular wall, Gallus gallus"
xref: Reactome:REACT_93252 "Cell surface interactions at the vascular wall, Rattus norvegicus"
xref: Reactome:REACT_98799 "Cell surface interactions at the vascular wall, Drosophila melanogaster"
is_a: GO:0002376 ! immune system process
is_a: GO:0016477 ! cell migration

[Term]
id: GO:0050901
name: leukocyte tethering or rolling
namespace: biological_process
def: "Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels. Carbohydrates on circulating leukocytes bind selectins on the vessel wall causing the leukocytes to slow down and roll along the inner surface of the vessel wall. During this rolling motion, transitory bonds are formed and broken between selectins and their ligands. Typically the first step in cellular extravasation (the movement of leukocytes out of the circulatory system, towards the site of tissue damage or infection)." [GOC:bf, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538, Wikipedia:Leukocyte_extravasation]
is_a: GO:0061756 ! leukocyte adhesion to vascular endothelial cell
relationship: part_of GO:0045123 ! cellular extravasation

[Term]
id: GO:0050902
name: leukocyte adhesive activation
namespace: biological_process
def: "The activation of loosely bound or rolling leukocytes by signals displayed on blood vessel endothelial cells, which is typically the second step in cellular extravasation." [ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538]
synonym: "leukocyte adhesive triggering" EXACT []
is_a: GO:0045321 ! leukocyte activation
relationship: part_of GO:0045123 ! cellular extravasation

[Term]
id: GO:0050903
name: leukocyte activation-dependent arrest
namespace: biological_process
def: "The formation of an integrin-dependent strong adhesive bond between leukocytes and blood vessel endothelial cells which is dependent on prior activation of the leukocyte and leads to the firm attachment of the leukocyte to the endothelial surface, typically the third step in cellular extravasation." [ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538]
is_a: GO:0061756 ! leukocyte adhesion to vascular endothelial cell
relationship: part_of GO:0045123 ! cellular extravasation

[Term]
id: GO:0050904
name: diapedesis
namespace: biological_process
def: "The passage of a leukocyte between the tight junctions of endothelial cells lining blood vessels, typically the fourth and final step of cellular extravasation." [ISBN:078173514, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538]
comment: Note that the term diapedesis, although sometimes used as a direct synonym for cellular extravasation, is used here for the specific final step of the process, in concordance with recent reviews of the topic.
is_a: GO:0050900 ! leukocyte migration
relationship: part_of GO:0045123 ! cellular extravasation

[Term]
id: GO:0050905
name: neuromuscular process
namespace: biological_process
def: "Any process pertaining to the functions of the nervous and muscular systems of an organism." [GOC:ai]
synonym: "neuromotor process" EXACT []
synonym: "neuromuscular physiological process" EXACT []
is_a: GO:0050877 ! neurological system process

[Term]
id: GO:0050906
name: detection of stimulus involved in sensory perception
namespace: biological_process
def: "The series of events involved in sensory perception in which a sensory stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos, GOC:dph]
synonym: "sensory detection of stimulus" EXACT []
synonym: "sensory perception, sensory transduction of stimulus" EXACT []
synonym: "sensory perception, stimulus detection" EXACT []
synonym: "sensory transduction" EXACT []
xref: Wikipedia:Transduction_(physiology)
is_a: GO:0051606 ! detection of stimulus
intersection_of: GO:0051606 ! detection of stimulus
intersection_of: part_of GO:0007600 ! sensory perception
relationship: part_of GO:0007600 ! sensory perception

[Term]
id: GO:0050907
name: detection of chemical stimulus involved in sensory perception
namespace: biological_process
def: "The series of events in which a chemical stimulus is received and converted into a molecular signal as part of sensory perception." [GOC:ai, GOC:dos]
synonym: "sensory detection of chemical stimulus" EXACT []
synonym: "sensory detection of chemical stimulus during sensory perception" EXACT []
synonym: "sensory perception, sensory detection of chemical stimulus" EXACT []
synonym: "sensory perception, sensory transduction of chemical stimulus" EXACT []
synonym: "sensory transduction of chemical stimulus" EXACT []
synonym: "sensory transduction of chemical stimulus during sensory perception" EXACT []
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0050906 ! detection of stimulus involved in sensory perception
intersection_of: GO:0009593 ! detection of chemical stimulus
intersection_of: part_of GO:0007600 ! sensory perception
relationship: part_of GO:0007600 ! sensory perception
relationship: part_of GO:0007606 ! sensory perception of chemical stimulus

[Term]
id: GO:0050908
name: detection of light stimulus involved in visual perception
namespace: biological_process
def: "The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]
synonym: "sensory detection of light during visual perception" EXACT []
synonym: "sensory detection of light stimulus during visual perception" EXACT []
synonym: "sensory transduction of light during visual perception" EXACT []
synonym: "sensory transduction of light stimulus during visual perception" EXACT []
synonym: "visual perception, detection of light stimulus" EXACT []
synonym: "visual perception, sensory transduction during perception of light" EXACT []
synonym: "visual perception, sensory transduction of light stimulus" EXACT []
is_a: GO:0009584 ! detection of visible light
is_a: GO:0050962 ! detection of light stimulus involved in sensory perception
intersection_of: GO:0009583 ! detection of light stimulus
intersection_of: part_of GO:0007601 ! visual perception
relationship: part_of GO:0007601 ! visual perception

[Term]
id: GO:0050909
name: sensory perception of taste
namespace: biological_process
def: "The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]
synonym: "gustation" EXACT []
synonym: "sense of taste" EXACT []
synonym: "taste" EXACT []
synonym: "taste perception" EXACT []
xref: Wikipedia:Taste
is_a: GO:0007606 ! sensory perception of chemical stimulus

[Term]
id: GO:0050910
name: detection of mechanical stimulus involved in sensory perception of sound
namespace: biological_process
alt_id: GO:0009592
alt_id: GO:0055128
def: "The series of events involved in the perception of sound vibration in which the vibration is received and converted into a molecular signal." [GOC:ai]
synonym: "detection of sound" EXACT []
synonym: "hearing, sensory transduction of sound" EXACT []
synonym: "perception of sound, detection of mechanical stimulus" EXACT []
synonym: "perception of sound, sensory detection of mechanical stimulus" EXACT []
synonym: "perception of sound, sensory transduction of mechanical stimulus" EXACT []
synonym: "sensory detection of mechanical stimulus during perception of sound" EXACT []
synonym: "sensory transduction of mechanical stimulus during perception of sound" EXACT []
synonym: "sensory transduction of sound" EXACT []
is_a: GO:0050877 ! neurological system process
is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception
intersection_of: GO:0050982 ! detection of mechanical stimulus
intersection_of: part_of GO:0007605 ! sensory perception of sound
relationship: part_of GO:0007605 ! sensory perception of sound

[Term]
id: GO:0050911
name: detection of chemical stimulus involved in sensory perception of smell
namespace: biological_process
def: "The series of events involved in the perception of smell in which an olfactory chemical stimulus is received and converted into a molecular signal." [GOC:ai]
synonym: "perception of smell, detection of chemical stimulus" EXACT []
synonym: "perception of smell, sensory detection of chemical stimulus" EXACT []
synonym: "perception of smell, sensory transduction of chemical stimulus" EXACT []
synonym: "sensory detection of chemical stimulus during perception of smell" EXACT []
synonym: "sensory detection of scent" EXACT []
synonym: "sensory detection of smell" EXACT []
synonym: "sensory transduction of chemical stimulus during perception of smell" EXACT []
synonym: "sensory transduction of scent" EXACT []
synonym: "sensory transduction of smell" EXACT []
is_a: GO:0050907 ! detection of chemical stimulus involved in sensory perception
intersection_of: GO:0009593 ! detection of chemical stimulus
intersection_of: part_of GO:0007608 ! sensory perception of smell
relationship: part_of GO:0007608 ! sensory perception of smell

[Term]
id: GO:0050912
name: detection of chemical stimulus involved in sensory perception of taste
namespace: biological_process
def: "The series of events involved in the perception of taste in which a gustatory chemical stimulus is received and converted into a molecular signal." [GOC:ai]
synonym: "perception of taste, detection of chemical stimulus" EXACT []
synonym: "perception of taste, sensory detection of chemical stimulus" EXACT []
synonym: "perception of taste, sensory transduction of chemical stimulus" EXACT []
synonym: "sensory detection of chemical stimulus during perception of taste" EXACT []
synonym: "sensory detection of taste" EXACT []
synonym: "sensory transduction of chemical stimulus during perception of taste" EXACT []
synonym: "sensory transduction of taste" EXACT []
synonym: "taste perception" BROAD []
is_a: GO:0050907 ! detection of chemical stimulus involved in sensory perception
intersection_of: GO:0009593 ! detection of chemical stimulus
intersection_of: part_of GO:0050909 ! sensory perception of taste
relationship: part_of GO:0050909 ! sensory perception of taste

[Term]
id: GO:0050913
name: sensory perception of bitter taste
namespace: biological_process
def: "The series of events required to receive a bitter taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
synonym: "bitter taste perception" EXACT []
is_a: GO:0050909 ! sensory perception of taste

[Term]
id: GO:0050914
name: sensory perception of salty taste
namespace: biological_process
def: "The series of events required to receive a salty taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
synonym: "salty taste perception" EXACT []
is_a: GO:0050909 ! sensory perception of taste

[Term]
id: GO:0050915
name: sensory perception of sour taste
namespace: biological_process
def: "The series of events required to receive a sour taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
synonym: "sour taste perception" EXACT []
is_a: GO:0050909 ! sensory perception of taste

[Term]
id: GO:0050916
name: sensory perception of sweet taste
namespace: biological_process
def: "The series of events required to receive a sweet taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
synonym: "sweet taste perception" EXACT []
is_a: GO:0050909 ! sensory perception of taste

[Term]
id: GO:0050917
name: sensory perception of umami taste
namespace: biological_process
def: "The series of events required to receive an umami taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. Umami taste is the savory taste of meats and other foods that are rich in glutamates. This is a neurological process." [GOC:ai]
synonym: "umami taste perception" EXACT []
is_a: GO:0050909 ! sensory perception of taste

[Term]
id: GO:0050918
name: positive chemotaxis
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a higher concentration of a chemical." [GOC:ai, GOC:bf, GOC:isa_complete]
subset: gosubset_prok
synonym: "chemoattraction" EXACT []
is_a: GO:0006935 ! chemotaxis

[Term]
id: GO:0050919
name: negative chemotaxis
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a lower concentration of a chemical." [GOC:ai, GOC:bf, GOC:isa_complete]
synonym: "chemoaversion" EXACT []
synonym: "chemorepulsion" EXACT []
is_a: GO:0006935 ! chemotaxis

[Term]
id: GO:0050920
name: regulation of chemotaxis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient." [GOC:ai]
subset: gosubset_prok
is_a: GO:0032101 ! regulation of response to external stimulus
is_a: GO:0040012 ! regulation of locomotion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006935 ! chemotaxis
relationship: regulates GO:0006935 ! chemotaxis

[Term]
id: GO:0050921
name: positive regulation of chemotaxis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient." [GOC:ai]
subset: gosubset_prok
synonym: "activation of chemotaxis" NARROW []
synonym: "stimulation of chemotaxis" NARROW []
synonym: "up regulation of chemotaxis" EXACT []
synonym: "up-regulation of chemotaxis" EXACT []
synonym: "upregulation of chemotaxis" EXACT []
is_a: GO:0032103 ! positive regulation of response to external stimulus
is_a: GO:0040017 ! positive regulation of locomotion
is_a: GO:0050920 ! regulation of chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006935 ! chemotaxis
relationship: positively_regulates GO:0006935 ! chemotaxis

[Term]
id: GO:0050922
name: negative regulation of chemotaxis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient." [GOC:ai]
synonym: "down regulation of chemotaxis" EXACT []
synonym: "down-regulation of chemotaxis" EXACT []
synonym: "downregulation of chemotaxis" EXACT []
synonym: "inhibition of chemotaxis" NARROW []
is_a: GO:0032102 ! negative regulation of response to external stimulus
is_a: GO:0040013 ! negative regulation of locomotion
is_a: GO:0050920 ! regulation of chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006935 ! chemotaxis
relationship: negatively_regulates GO:0006935 ! chemotaxis

[Term]
id: GO:0050923
name: regulation of negative chemotaxis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical." [GOC:ai]
is_a: GO:0050920 ! regulation of chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050919 ! negative chemotaxis
relationship: regulates GO:0050919 ! negative chemotaxis

[Term]
id: GO:0050924
name: positive regulation of negative chemotaxis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical." [GOC:ai]
synonym: "activation of negative chemotaxis" NARROW []
synonym: "stimulation of negative chemotaxis" NARROW []
synonym: "up regulation of negative chemotaxis" EXACT []
synonym: "up-regulation of negative chemotaxis" EXACT []
synonym: "upregulation of negative chemotaxis" EXACT []
is_a: GO:0050921 ! positive regulation of chemotaxis
is_a: GO:0050923 ! regulation of negative chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0050919 ! negative chemotaxis
relationship: positively_regulates GO:0050919 ! negative chemotaxis

[Term]
id: GO:0050925
name: negative regulation of negative chemotaxis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical." [GOC:ai]
synonym: "down regulation of negative chemotaxis" EXACT []
synonym: "down-regulation of negative chemotaxis" EXACT []
synonym: "downregulation of negative chemotaxis" EXACT []
synonym: "inhibition of negative chemotaxis" NARROW []
is_a: GO:0050922 ! negative regulation of chemotaxis
is_a: GO:0050923 ! regulation of negative chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0050919 ! negative chemotaxis
relationship: negatively_regulates GO:0050919 ! negative chemotaxis

[Term]
id: GO:0050926
name: regulation of positive chemotaxis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical." [GOC:ai]
subset: gosubset_prok
is_a: GO:0050920 ! regulation of chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050918 ! positive chemotaxis
relationship: regulates GO:0050918 ! positive chemotaxis

[Term]
id: GO:0050927
name: positive regulation of positive chemotaxis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical." [GOC:ai]
subset: gosubset_prok
synonym: "activation of positive chemotaxis" NARROW []
synonym: "stimulation of positive chemotaxis" NARROW []
synonym: "up regulation of positive chemotaxis" EXACT []
synonym: "up-regulation of positive chemotaxis" EXACT []
synonym: "upregulation of positive chemotaxis" EXACT []
is_a: GO:0050921 ! positive regulation of chemotaxis
is_a: GO:0050926 ! regulation of positive chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0050918 ! positive chemotaxis
relationship: positively_regulates GO:0050918 ! positive chemotaxis

[Term]
id: GO:0050928
name: negative regulation of positive chemotaxis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical." [GOC:ai]
synonym: "down regulation of positive chemotaxis" EXACT []
synonym: "down-regulation of positive chemotaxis" EXACT []
synonym: "downregulation of positive chemotaxis" EXACT []
synonym: "inhibition of positive chemotaxis" NARROW []
is_a: GO:0050922 ! negative regulation of chemotaxis
is_a: GO:0050926 ! regulation of positive chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0050918 ! positive chemotaxis
relationship: negatively_regulates GO:0050918 ! positive chemotaxis

[Term]
id: GO:0050929
name: induction of negative chemotaxis
namespace: biological_process
def: "Any process that initiates the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical." [GOC:ai]
is_a: GO:0050924 ! positive regulation of negative chemotaxis

[Term]
id: GO:0050930
name: induction of positive chemotaxis
namespace: biological_process
def: "Any process that initiates the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical." [GOC:ai]
subset: gosubset_prok
is_a: GO:0050927 ! positive regulation of positive chemotaxis

[Term]
id: GO:0050931
name: pigment cell differentiation
namespace: biological_process
alt_id: GO:0043357
alt_id: GO:0043358
def: "The process in which a relatively unspecialized cell acquires the specialized features of a pigmented cell, such as a melanocyte." [GOC:dgh]
comment: Note that the chromatophore mentioned here is distinct from the pigment bearing structure found in certain photosynthetic bacteria and cyanobacteria. It is also different from the plant chromoplast, which is also sometimes called a chromatophore.
synonym: "chromatophore differentiation" EXACT []
synonym: "pigmented cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0048066 ! developmental pigmentation

[Term]
id: GO:0050932
name: regulation of pigment cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pigmented cell differentiation." [GOC:ai]
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:0048070 ! regulation of developmental pigmentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050931 ! pigment cell differentiation
relationship: regulates GO:0050931 ! pigment cell differentiation

[Term]
id: GO:0050933
name: early stripe melanocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of an early stripe melanocyte (ESM). In zebrafish, ESMs develop during the first phase (2-3 weeks of development) of the larva to adult transition (2-4 weeks of development)." [PMID:11858836]
synonym: "early stripe melanocyte cell differentiation" EXACT []
synonym: "early stripe melanophore differentiation" EXACT []
is_a: GO:0030318 ! melanocyte differentiation

[Term]
id: GO:0050934
name: late stripe melanocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a late stripe melanocyte (LSM). In zebrafish, LSMs develop during the second phase (3-4 weeks of development) of the larva-to-adult transition (2-4 weeks of development)." [PMID:11858836]
synonym: "late stripe melanocyte cell differentiation" EXACT []
synonym: "late stripe melanophore differentiation" EXACT []
is_a: GO:0030318 ! melanocyte differentiation

[Term]
id: GO:0050935
name: iridophore differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of an iridophore. Iridophores are pigment cells derived from the neural crest. They contain guanidine or other purine crystals deposited in stacks called reflecting platets or iridisomes. This gives them a silver, gold, or iridescent appearance." [GOC:jid, GOC:mh, PMID:11858836]
synonym: "iridophore cell differentiation" EXACT []
is_a: GO:0050931 ! pigment cell differentiation

[Term]
id: GO:0050936
name: xanthophore differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a xanthophore cell. Xanthophores are pigment cells derived from the neural crest. They contain pteridine and/or carotenoid pigments in structures called pterinosomes or xanthosomes. This makes them yellow to orange in appearance." [GOC:jid, GOC:mh, PMID:11858836]
comment: Note that this term refers to xanthophores in the sense of specialized pigment-producing cells, and should not be confused with the cellular component term 'xanthophore ; GO:0031633', which refers to a subcellular structure.
synonym: "xanthophore cell differentiation" EXACT []
is_a: GO:0050931 ! pigment cell differentiation

[Term]
id: GO:0050937
name: regulation of iridophore differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of iridophore differentiation." [GOC:ai]
is_a: GO:0050932 ! regulation of pigment cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050935 ! iridophore differentiation
relationship: regulates GO:0050935 ! iridophore differentiation

[Term]
id: GO:0050938
name: regulation of xanthophore differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of xanthophore differentiation." [GOC:ai]
comment: Note that this term refers to xanthophores in the sense of specialized pigment-producing cells, and should not be confused with the cellular component term 'xanthophore ; GO:0031633', which refers to a subcellular structure.
is_a: GO:0050932 ! regulation of pigment cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050936 ! xanthophore differentiation
relationship: regulates GO:0050936 ! xanthophore differentiation

[Term]
id: GO:0050939
name: regulation of early stripe melanocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of early stripe melanocyte differentiation." [GOC:ai]
synonym: "regulation of early stripe melanophore differentiation" EXACT []
is_a: GO:0045634 ! regulation of melanocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050933 ! early stripe melanocyte differentiation
relationship: regulates GO:0050933 ! early stripe melanocyte differentiation

[Term]
id: GO:0050940
name: regulation of late stripe melanocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of late stripe melanocyte differentiation." [GOC:ai]
synonym: "regulation of late stripe melanophore differentiation" EXACT []
is_a: GO:0045634 ! regulation of melanocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050934 ! late stripe melanocyte differentiation
relationship: regulates GO:0050934 ! late stripe melanocyte differentiation

[Term]
id: GO:0050941
name: negative regulation of pigment cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pigment cell differentiation." [GOC:ai]
synonym: "down regulation of pigment cell differentiation" EXACT []
synonym: "down-regulation of pigment cell differentiation" EXACT []
synonym: "downregulation of pigment cell differentiation" EXACT []
synonym: "inhibition of pigment cell differentiation" NARROW []
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0048086 ! negative regulation of developmental pigmentation
is_a: GO:0050932 ! regulation of pigment cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0050931 ! pigment cell differentiation
relationship: negatively_regulates GO:0050931 ! pigment cell differentiation

[Term]
id: GO:0050942
name: positive regulation of pigment cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pigment cell differentiation." [GOC:ai]
synonym: "activation of pigment cell differentiation" NARROW []
synonym: "stimulation of pigment cell differentiation" NARROW []
synonym: "up regulation of pigment cell differentiation" EXACT []
synonym: "up-regulation of pigment cell differentiation" EXACT []
synonym: "upregulation of pigment cell differentiation" EXACT []
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0048087 ! positive regulation of developmental pigmentation
is_a: GO:0050932 ! regulation of pigment cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0050931 ! pigment cell differentiation
relationship: positively_regulates GO:0050931 ! pigment cell differentiation

[Term]
id: GO:0050943
name: negative regulation of iridophore differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of iridophore differentiation." [GOC:ai]
synonym: "down regulation of iridophore differentiation" EXACT []
synonym: "down-regulation of iridophore differentiation" EXACT []
synonym: "downregulation of iridophore differentiation" EXACT []
synonym: "inhibition of iridophore differentiation" NARROW []
is_a: GO:0050937 ! regulation of iridophore differentiation
is_a: GO:0050941 ! negative regulation of pigment cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0050935 ! iridophore differentiation
relationship: negatively_regulates GO:0050935 ! iridophore differentiation

[Term]
id: GO:0050944
name: negative regulation of xanthophore differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of xanthophore differentiation." [GOC:ai]
comment: Note that this term refers to xanthophores in the sense of specialized pigment-producing cells, and should not be confused with the cellular component term 'xanthophore ; GO:0031633', which refers to a subcellular structure.
synonym: "down regulation of xanthophore differentiation" EXACT []
synonym: "down-regulation of xanthophore differentiation" EXACT []
synonym: "downregulation of xanthophore differentiation" EXACT []
synonym: "inhibition of xanthophore differentiation" NARROW []
is_a: GO:0050938 ! regulation of xanthophore differentiation
is_a: GO:0050941 ! negative regulation of pigment cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0050936 ! xanthophore differentiation
relationship: negatively_regulates GO:0050936 ! xanthophore differentiation

[Term]
id: GO:0050945
name: positive regulation of iridophore differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of iridophore differentiation." [GOC:ai]
synonym: "activation of iridophore differentiation" NARROW []
synonym: "stimulation of iridophore differentiation" NARROW []
synonym: "up regulation of iridophore differentiation" EXACT []
synonym: "up-regulation of iridophore differentiation" EXACT []
synonym: "upregulation of iridophore differentiation" EXACT []
is_a: GO:0050937 ! regulation of iridophore differentiation
is_a: GO:0050942 ! positive regulation of pigment cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0050935 ! iridophore differentiation
relationship: positively_regulates GO:0050935 ! iridophore differentiation

[Term]
id: GO:0050946
name: positive regulation of xanthophore differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of xanthophore differentiation." [GOC:ai]
comment: Note that this term refers to xanthophores in the sense of specialized pigment-producing cells, and should not be confused with the cellular component term 'xanthophore ; GO:0031633', which refers to a subcellular structure.
synonym: "activation of xanthophore differentiation" NARROW []
synonym: "stimulation of xanthophore differentiation" NARROW []
synonym: "up regulation of xanthophore differentiation" EXACT []
synonym: "up-regulation of xanthophore differentiation" EXACT []
synonym: "upregulation of xanthophore differentiation" EXACT []
is_a: GO:0050938 ! regulation of xanthophore differentiation
is_a: GO:0050942 ! positive regulation of pigment cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0050936 ! xanthophore differentiation
relationship: positively_regulates GO:0050936 ! xanthophore differentiation

[Term]
id: GO:0050947
name: negative regulation of early stripe melanocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of early stripe melanocyte differentiation." [GOC:ai]
synonym: "down regulation of early stripe melanocyte differentiation" EXACT []
synonym: "down-regulation of early stripe melanocyte differentiation" EXACT []
synonym: "downregulation of early stripe melanocyte differentiation" EXACT []
synonym: "inhibition of early stripe melanocyte differentiation" NARROW []
synonym: "negative regulation of early stripe melanophore differentiation" EXACT []
is_a: GO:0045635 ! negative regulation of melanocyte differentiation
is_a: GO:0050939 ! regulation of early stripe melanocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0050933 ! early stripe melanocyte differentiation
relationship: negatively_regulates GO:0050933 ! early stripe melanocyte differentiation

[Term]
id: GO:0050948
name: positive regulation of early stripe melanocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of early stripe melanocyte differentiation." [GOC:ai]
synonym: "activation of early stripe melanocyte differentiation" NARROW []
synonym: "positive regulation of early stripe melanophore differentiation" EXACT []
synonym: "stimulation of early stripe melanocyte differentiation" NARROW []
synonym: "up regulation of early stripe melanocyte differentiation" EXACT []
synonym: "up-regulation of early stripe melanocyte differentiation" EXACT []
synonym: "upregulation of early stripe melanocyte differentiation" EXACT []
is_a: GO:0045636 ! positive regulation of melanocyte differentiation
is_a: GO:0050939 ! regulation of early stripe melanocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0050933 ! early stripe melanocyte differentiation
relationship: positively_regulates GO:0050933 ! early stripe melanocyte differentiation

[Term]
id: GO:0050949
name: negative regulation of late stripe melanocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of late stripe melanocyte differentiation." [GOC:ai]
synonym: "down regulation of late stripe melanocyte differentiation" EXACT []
synonym: "down-regulation of late stripe melanocyte differentiation" EXACT []
synonym: "downregulation of late stripe melanocyte differentiation" EXACT []
synonym: "inhibition of late stripe melanocyte differentiation" NARROW []
synonym: "negative regulation of late stripe melanophore differentiation" EXACT []
is_a: GO:0045635 ! negative regulation of melanocyte differentiation
is_a: GO:0050940 ! regulation of late stripe melanocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0050934 ! late stripe melanocyte differentiation
relationship: negatively_regulates GO:0050934 ! late stripe melanocyte differentiation

[Term]
id: GO:0050950
name: positive regulation of late stripe melanocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of late stripe melanocyte differentiation." [GOC:ai]
synonym: "activation of late stripe melanocyte differentiation" NARROW []
synonym: "positive regulation of late stripe melanophore differentiation" EXACT []
synonym: "stimulation of late stripe melanocyte differentiation" NARROW []
synonym: "up regulation of late stripe melanocyte differentiation" EXACT []
synonym: "up-regulation of late stripe melanocyte differentiation" EXACT []
synonym: "upregulation of late stripe melanocyte differentiation" EXACT []
is_a: GO:0045636 ! positive regulation of melanocyte differentiation
is_a: GO:0050940 ! regulation of late stripe melanocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0050934 ! late stripe melanocyte differentiation
relationship: positively_regulates GO:0050934 ! late stripe melanocyte differentiation

[Term]
id: GO:0050951
name: sensory perception of temperature stimulus
namespace: biological_process
def: "The series of events required for an organism to receive a sensory temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
synonym: "sensory perception of thermal stimulus" EXACT []
is_a: GO:0007600 ! sensory perception

[Term]
id: GO:0050952
name: sensory perception of electrical stimulus
namespace: biological_process
def: "The series of events required for an organism to receive a sensory electrical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
is_a: GO:0007600 ! sensory perception

[Term]
id: GO:0050953
name: sensory perception of light stimulus
namespace: biological_process
def: "The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
is_a: GO:0007600 ! sensory perception

[Term]
id: GO:0050954
name: sensory perception of mechanical stimulus
namespace: biological_process
def: "The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
synonym: "chemi-mechanical coupling" RELATED []
synonym: "mechanosensory perception" EXACT []
synonym: "perception of mechanical stimulus" EXACT []
is_a: GO:0007600 ! sensory perception

[Term]
id: GO:0050955
name: thermoception
namespace: biological_process
def: "The series of events required for an organism to receive a temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal. Thermoception in larger animals is mainly done in the skin; mammals have at least two types of sensor, for detecting heat (temperatures above body temperature) and cold (temperatures below body temperature)." [GOC:ai, Wikipedia:Thermoception]
synonym: "thermoreception" EXACT []
xref: Wikipedia:Thermoception
is_a: GO:0050951 ! sensory perception of temperature stimulus

[Term]
id: GO:0050956
name: electroception
namespace: biological_process
def: "The series of events required for an organism to receive an electrical stimulus, convert it to a molecular signal, and recognize and characterize the signal. Many fish possess an electroception sense; for example, the electric eel uses low voltage pulses of electricity for navigation and prey location." [GOC:ai, PMID:10210663, Wikipedia:Electroreception]
synonym: "electroception sense" EXACT []
synonym: "electroceptive sense" EXACT []
xref: Wikipedia:Electroreception
is_a: GO:0050952 ! sensory perception of electrical stimulus

[Term]
id: GO:0050957
name: equilibrioception
namespace: biological_process
def: "The series of events required for an organism to receive an orientational stimulus, convert it to a molecular signal, and recognize and characterize the signal. Equilibrioception refers to a combination of processes by which an organism can perceive its orientation with respect to gravity. In animals, stimuli come from labyrinth system of the inner ears, monitoring the direction of motion; visual stimuli, with information on orientation and motion; pressure receptors, which tell the organism which body surfaces are in contact with the ground; and proprioceptive cues, which report which parts of the body are in motion." [http://www.medterms.com, http://www.onelook.com/]
synonym: "sensory perception of orientation with respect to gravity" EXACT []
xref: Wikipedia:Equilibrioception
is_a: GO:0007600 ! sensory perception
relationship: part_of GO:0050885 ! neuromuscular process controlling balance

[Term]
id: GO:0050958
name: magnetoreception
namespace: biological_process
def: "The series of events required for an organism to receive a stimulus relating to a magnetic field, convert it to a molecular signal, and recognize and characterize the signal. Stimuli may be chemical, mechanical or electrical and interpreting these stimuli allows an organism to determine the orientation of a magnetic field. Magnetoreception also involves the perception of light; birds cannot orient without the presence of short wavelength (blue/green) light." [GOC:ai, PMID:15886990, Wikipedia:Magnetoception]
synonym: "magnetoception" EXACT []
synonym: "sensory perception of magnetic field" EXACT []
xref: Wikipedia:Magnetoception
is_a: GO:0007600 ! sensory perception

[Term]
id: GO:0050959
name: echolocation
namespace: biological_process
def: "Echolocation is the method used by some animals (e.g. bats, dolphins and some whales) to determine the location of something by measuring the time it takes for an echo to return from it. These animals emit sound waves and listen for the echo, calculating the distance to the object from the time lapse between sound emission and the echo returning." [http://www.onelook.com/, PMID:16005275, Wikipedia:Animal_echolocation]
synonym: "perception of environment using reflected sound waves" EXACT []
xref: Wikipedia:Echolocation
is_a: GO:0050877 ! neurological system process

[Term]
id: GO:0050960
name: detection of temperature stimulus involved in thermoception
namespace: biological_process
def: "The series of events in which a temperature stimulus is received and converted into a molecular signal as part of thermoception." [GOC:ai, GOC:dos]
synonym: "sensory detection of heat stimulus during thermoception" NARROW []
synonym: "sensory detection of temperature stimulus during thermoception" EXACT []
synonym: "sensory detection of thermal stimulus during thermoception" EXACT []
synonym: "sensory transduction of heat stimulus during thermoception" NARROW []
synonym: "sensory transduction of temperature stimulus during thermoception" EXACT []
synonym: "sensory transduction of thermal stimulus during thermoception" EXACT []
synonym: "thermoception, sensory detection of heat stimulus" NARROW []
synonym: "thermoception, sensory detection of temperature stimulus" EXACT []
synonym: "thermoception, sensory detection of thermal stimulus" EXACT []
synonym: "thermoception, sensory transduction of heat stimulus" NARROW []
synonym: "thermoception, sensory transduction of temperature stimulus" EXACT []
synonym: "thermoception, sensory transduction of thermal stimulus" EXACT []
is_a: GO:0050961 ! detection of temperature stimulus involved in sensory perception
intersection_of: GO:0016048 ! detection of temperature stimulus
intersection_of: part_of GO:0050955 ! thermoception
relationship: part_of GO:0050955 ! thermoception

[Term]
id: GO:0050961
name: detection of temperature stimulus involved in sensory perception
namespace: biological_process
def: "The series of events in which a temperature stimulus is received and converted into a molecular signal as part of sensory perception." [GOC:ai, GOC:dos]
synonym: "sensory detection of heat stimulus during sensory perception" NARROW []
synonym: "sensory detection of temperature stimulus" EXACT []
synonym: "sensory detection of temperature stimulus during sensory perception" EXACT []
synonym: "sensory detection of thermal stimulus during sensory perception" EXACT []
synonym: "sensory perception, sensory detection of heat stimulus" NARROW []
synonym: "sensory perception, sensory detection of temperature stimulus" EXACT []
synonym: "sensory perception, sensory detection of thermal stimulus" EXACT []
synonym: "sensory perception, sensory transduction of heat stimulus" NARROW []
synonym: "sensory perception, sensory transduction of temperature stimulus" EXACT []
synonym: "sensory perception, sensory transduction of thermal stimulus" EXACT []
synonym: "sensory transduction of heat stimulus during sensory perception" NARROW []
synonym: "sensory transduction of temperature stimulus" EXACT []
synonym: "sensory transduction of temperature stimulus during sensory perception" EXACT []
synonym: "sensory transduction of thermal stimulus during sensory perception" EXACT []
is_a: GO:0016048 ! detection of temperature stimulus
is_a: GO:0050906 ! detection of stimulus involved in sensory perception
intersection_of: GO:0016048 ! detection of temperature stimulus
intersection_of: part_of GO:0007600 ! sensory perception
relationship: part_of GO:0007600 ! sensory perception
relationship: part_of GO:0050951 ! sensory perception of temperature stimulus

[Term]
id: GO:0050962
name: detection of light stimulus involved in sensory perception
namespace: biological_process
def: "The series of events in which a light stimulus is received by a cell and converted into a molecular signal as part of the sensory perception of light." [GOC:ai, GOC:dos]
synonym: "sensory detection of light stimulus" EXACT []
synonym: "sensory detection of light stimulus during sensory perception" EXACT []
synonym: "sensory perception, sensory detection of light stimulus" EXACT []
synonym: "sensory perception, sensory transduction of light stimulus" EXACT []
synonym: "sensory transduction of light stimulus" EXACT []
synonym: "sensory transduction of light stimulus during sensory perception" EXACT []
is_a: GO:0009583 ! detection of light stimulus
is_a: GO:0050906 ! detection of stimulus involved in sensory perception
intersection_of: GO:0009583 ! detection of light stimulus
intersection_of: part_of GO:0007600 ! sensory perception
relationship: part_of GO:0007600 ! sensory perception
relationship: part_of GO:0050953 ! sensory perception of light stimulus

[Term]
id: GO:0050963
name: detection of electrical stimulus involved in sensory perception
namespace: biological_process
def: "The series of events in which an electrical stimulus is received by a cell and converted into a molecular signal as part of sensory perception." [GOC:ai, GOC:dos]
synonym: "sensory detection of electrical stimulus" EXACT []
synonym: "sensory detection of electrical stimulus during sensory perception" EXACT []
synonym: "sensory perception, sensory detection of electrical stimulus" EXACT []
synonym: "sensory perception, sensory transduction of electrical stimulus" EXACT []
synonym: "sensory transduction of electrical stimulus" EXACT []
synonym: "sensory transduction of electrical stimulus during sensory perception" EXACT []
is_a: GO:0050906 ! detection of stimulus involved in sensory perception
is_a: GO:0050981 ! detection of electrical stimulus
intersection_of: GO:0050981 ! detection of electrical stimulus
intersection_of: part_of GO:0007600 ! sensory perception
relationship: part_of GO:0007600 ! sensory perception
relationship: part_of GO:0050952 ! sensory perception of electrical stimulus

[Term]
id: GO:0050964
name: detection of electrical stimulus involved in electroception
namespace: biological_process
def: "The series of events that contribute to electroception in which an electrical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]
synonym: "detection of electrical stimulus during electroreception" RELATED [GOC:dph, GOC:tb]
synonym: "electroception, detection of electrical stimulus" EXACT []
synonym: "electroception, sensory detection of electrical stimulus" EXACT []
synonym: "electroception, sensory transduction" EXACT []
synonym: "electroception, sensory transduction of electrical stimulus" EXACT []
synonym: "sensory detection of electrical stimulus during electroception" RELATED []
synonym: "sensory transduction of electrical stimulus during electroception" RELATED []
is_a: GO:0050963 ! detection of electrical stimulus involved in sensory perception
intersection_of: GO:0050981 ! detection of electrical stimulus
intersection_of: part_of GO:0050956 ! electroception
relationship: part_of GO:0050956 ! electroception

[Term]
id: GO:0050965
name: detection of temperature stimulus involved in sensory perception of pain
namespace: biological_process
def: "The series of events involved in the perception of pain in which a temperature stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]
synonym: "perception of pain, detection of temperature stimulus" EXACT []
synonym: "perception of pain, sensory detection of temperature stimulus" EXACT []
synonym: "perception of pain, sensory transduction of temperature stimulus" EXACT []
synonym: "sensory detection of temperature stimulus during perception of pain" EXACT []
synonym: "sensory detection of thermal stimulus during sensory perception of pain" EXACT []
synonym: "sensory perception of pain, sensory detection of thermal stimulus" EXACT []
synonym: "sensory perception of pain, sensory transduction of thermal stimulus" EXACT []
synonym: "sensory transduction of temperature stimulus during perception of pain" EXACT []
synonym: "sensory transduction of thermal stimulus during sensory perception of pain" EXACT []
synonym: "thermal nociception" RELATED [GOC:pr]
is_a: GO:0050961 ! detection of temperature stimulus involved in sensory perception
intersection_of: GO:0016048 ! detection of temperature stimulus
intersection_of: part_of GO:0019233 ! sensory perception of pain
relationship: part_of GO:0019233 ! sensory perception of pain

[Term]
id: GO:0050966
name: detection of mechanical stimulus involved in sensory perception of pain
namespace: biological_process
def: "The series of events involved in the perception of pain in which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]
synonym: "mechanical nociception" RELATED [GOC:pr]
synonym: "perception of pain, detection of mechanical stimulus" EXACT []
synonym: "perception of pain, sensory detection of mechanical stimulus" EXACT []
synonym: "perception of pain, sensory transduction of mechanical stimulus" EXACT []
synonym: "sensory detection of mechanical stimulus during perception of pain" EXACT []
synonym: "sensory transduction of mechanical stimulus during perception of pain" EXACT []
is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception
intersection_of: GO:0050982 ! detection of mechanical stimulus
intersection_of: part_of GO:0019233 ! sensory perception of pain
relationship: part_of GO:0019233 ! sensory perception of pain

[Term]
id: GO:0050967
name: detection of electrical stimulus involved in sensory perception of pain
namespace: biological_process
def: "The series of events that contribute to the perception of pain in which an electrical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos, GOC:dph, GOC:tb]
synonym: "detection of electrical stimulus during sensory perception of pain" RELATED [GOC:dph, GOC:tb]
synonym: "perception of pain, detection of electrical stimulus" EXACT []
synonym: "perception of pain, sensory detection of electrical stimulus" EXACT []
synonym: "perception of pain, sensory transduction of electrical stimulus" EXACT []
synonym: "sensory detection of electrical stimulus during perception of pain" RELATED []
synonym: "sensory transduction of electrical stimulus during perception of pain" RELATED []
is_a: GO:0050963 ! detection of electrical stimulus involved in sensory perception
intersection_of: GO:0050981 ! detection of electrical stimulus
intersection_of: part_of GO:0019233 ! sensory perception of pain
relationship: part_of GO:0019233 ! sensory perception of pain

[Term]
id: GO:0050968
name: detection of chemical stimulus involved in sensory perception of pain
namespace: biological_process
def: "The series of events involved in the perception of pain in which a chemical stimulus is received and converted into a molecular signal." [GOC:ai]
synonym: "chemical nociception" RELATED [GOC:pr]
synonym: "perception of pain, detection of chemical stimulus" EXACT []
synonym: "perception of pain, sensory detection of chemical stimulus" EXACT []
synonym: "perception of pain, sensory transduction of chemical stimulus" EXACT []
synonym: "sensory detection of chemical stimulus during perception of pain" EXACT []
synonym: "sensory transduction of chemical stimulus during perception of pain" EXACT []
is_a: GO:0050907 ! detection of chemical stimulus involved in sensory perception
intersection_of: GO:0009593 ! detection of chemical stimulus
intersection_of: part_of GO:0019233 ! sensory perception of pain
relationship: part_of GO:0019233 ! sensory perception of pain

[Term]
id: GO:0050969
name: detection of chemical stimulus involved in magnetoreception
namespace: biological_process
def: "The series of events involved in magnetoception in which a chemical stimulus is received and converted into a molecular signal. It is believed that organisms such as birds and salamanders interpret product ratios in chemical reactions which involve transitions between different spin states." [GOC:ai, GOC:dos]
synonym: "magnetoception, sensory transduction of chemical stimulus" EXACT []
synonym: "magnetoreception, detection of chemical stimulus" EXACT []
synonym: "magnetoreception, sensory detection of chemical stimulus" EXACT []
synonym: "magnetoreception, sensory transduction of chemical stimulus" EXACT []
synonym: "sensory detection of chemical stimulus during magnetoreception" EXACT []
synonym: "sensory transduction of chemical stimulus during magnetoreception" EXACT []
is_a: GO:0050907 ! detection of chemical stimulus involved in sensory perception
intersection_of: GO:0009593 ! detection of chemical stimulus
intersection_of: part_of GO:0050958 ! magnetoreception
relationship: part_of GO:0050958 ! magnetoreception
relationship: part_of GO:0050977 ! magnetoreception by sensory perception of chemical stimulus

[Term]
id: GO:0050970
name: detection of electrical stimulus involved in magnetoreception
namespace: biological_process
def: "The series of events that contribute to magnetoception in which an electrical stimulus is received and converted into a molecular signal. The stimulus is in the form of an induced electric field resulting from movement in a magnetic field." [GOC:ai, GOC:dos, GOC:dph, GOC:tb, PMID:15886990, Wikipedia:Magnetoception]
synonym: "detection of electrical stimulus during magnetoreception" RELATED [GOC:dph, GOC:tb]
synonym: "magnetoception, sensory transduction of electrical stimulus" EXACT []
synonym: "magnetoreception, detection of electrical stimulus" EXACT []
synonym: "magnetoreception, sensory detection of electrical stimulus" EXACT []
synonym: "magnetoreception, sensory transduction of electrical stimulus" EXACT []
synonym: "sensory detection of electrical stimulus during magnetoreception" RELATED []
synonym: "sensory transduction of electrical stimulus during magnetoreception" RELATED []
is_a: GO:0050963 ! detection of electrical stimulus involved in sensory perception
intersection_of: GO:0050981 ! detection of electrical stimulus
intersection_of: part_of GO:0050958 ! magnetoreception
relationship: part_of GO:0050958 ! magnetoreception
relationship: part_of GO:0050978 ! magnetoreception by sensory perception of electrical stimulus

[Term]
id: GO:0050971
name: detection of mechanical stimulus involved in magnetoreception
namespace: biological_process
def: "The series of events involved in magnetoception in which a mechanical stimulus is received and converted into a molecular signal. The stimulus is in the form of torque on particles such as magnetite which respond to a magnetic field." [GOC:ai, GOC:dos]
synonym: "magnetoception, sensory transduction of mechanical stimulus" EXACT []
synonym: "magnetoreception, detection of mechanical stimulus" EXACT []
synonym: "magnetoreception, sensory detection of mechanical stimulus" EXACT []
synonym: "magnetoreception, sensory transduction of mechanical stimulus" EXACT []
synonym: "sensory detection of mechanical stimulus during magnetoreception" EXACT []
synonym: "sensory transduction of mechanical stimulus during magnetoreception" EXACT []
is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception
intersection_of: GO:0050982 ! detection of mechanical stimulus
intersection_of: part_of GO:0050958 ! magnetoreception
relationship: part_of GO:0050958 ! magnetoreception
relationship: part_of GO:0050979 ! magnetoreception by sensory perception of mechanical stimulus

[Term]
id: GO:0050972
name: detection of mechanical stimulus involved in echolocation
namespace: biological_process
def: "The series of events involved in echolocation in which a mechanical stimulus is received and converted into a molecular signal. The stimulus is in the form of a reflected sound wave (an echo), which the organism uses to determine the distance to the object that reflected the sound wave." [GOC:ai, GOC:dos]
synonym: "echolocation, detection of mechanical stimulus" EXACT []
synonym: "echolocation, sensory detection of mechanical stimulus" EXACT []
synonym: "echolocation, sensory transduction of mechanical stimulus" EXACT []
synonym: "sensory detection of mechanical stimulus during echolocation" EXACT []
synonym: "sensory transduction of mechanical stimulus during echolocation" EXACT []
is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception
intersection_of: GO:0050982 ! detection of mechanical stimulus
intersection_of: part_of GO:0050959 ! echolocation
relationship: part_of GO:0050959 ! echolocation

[Term]
id: GO:0050973
name: detection of mechanical stimulus involved in equilibrioception
namespace: biological_process
def: "The series of events involved in equilibrioception in which a mechanical stimulus is received and converted into a molecular signal. During equilibrioception, mechanical stimuli may be in the form of input from pressure receptors or from the labyrinth system of the inner ears." [GOC:ai, GOC:dos]
synonym: "equilibrioception, detection of mechanical stimulus" EXACT []
synonym: "equilibrioception, sensory detection of mechanical stimulus" EXACT []
synonym: "equilibrioception, sensory transduction of mechanical stimulus" EXACT []
synonym: "sensory detection of mechanical stimulus during equilibrioception" EXACT []
synonym: "sensory transduction of mechanical stimulus during equilibrioception" EXACT []
is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception
intersection_of: GO:0050982 ! detection of mechanical stimulus
intersection_of: part_of GO:0050957 ! equilibrioception
relationship: part_of GO:0050957 ! equilibrioception

[Term]
id: GO:0050974
name: detection of mechanical stimulus involved in sensory perception
namespace: biological_process
def: "The series of events in which a mechanical stimulus is received and converted into a molecular signal as part of sensory perception." [GOC:ai, GOC:dos]
synonym: "sensory detection of mechanical stimulus" EXACT []
synonym: "sensory detection of mechanical stimulus during sensory perception" EXACT []
synonym: "sensory perception, sensory detection of mechanical stimulus" EXACT []
synonym: "sensory perception, sensory transduction of mechanical stimulus" EXACT []
synonym: "sensory transduction of mechanical stimulus" EXACT []
synonym: "sensory transduction of mechanical stimulus during sensory perception" EXACT []
is_a: GO:0050906 ! detection of stimulus involved in sensory perception
is_a: GO:0050982 ! detection of mechanical stimulus
intersection_of: GO:0050982 ! detection of mechanical stimulus
intersection_of: part_of GO:0007600 ! sensory perception
relationship: part_of GO:0007600 ! sensory perception
relationship: part_of GO:0050954 ! sensory perception of mechanical stimulus

[Term]
id: GO:0050975
name: sensory perception of touch
namespace: biological_process
def: "The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach)." [GOC:ai]
synonym: "perception of touch" EXACT []
synonym: "tactile sense" EXACT []
synonym: "taction" EXACT []
synonym: "tactition" EXACT []
xref: Wikipedia:Touch
is_a: GO:0050954 ! sensory perception of mechanical stimulus

[Term]
id: GO:0050976
name: detection of mechanical stimulus involved in sensory perception of touch
namespace: biological_process
def: "The series of events involved in the perception of touch in which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]
synonym: "perception of touch, detection of mechanical stimulus" EXACT []
synonym: "perception of touch, sensory detection of mechanical stimulus" EXACT []
synonym: "perception of touch, sensory transduction of mechanical stimulus" EXACT []
synonym: "sensory detection of mechanical stimulus during perception of touch" EXACT []
synonym: "sensory transduction of mechanical stimulus during perception of touch" EXACT []
synonym: "tactition, sensory detection of mechanical stimulus" EXACT []
is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception
intersection_of: GO:0050982 ! detection of mechanical stimulus
intersection_of: part_of GO:0050975 ! sensory perception of touch
relationship: part_of GO:0050975 ! sensory perception of touch

[Term]
id: GO:0050977
name: magnetoreception by sensory perception of chemical stimulus
namespace: biological_process
def: "The series of events required for an organism to receive a chemical stimulus relating to a magnetic field, convert it to a molecular signal, and recognize and characterize the signal. It is believed that organisms such as birds and salamanders use a 'chemical compass': chemical reactions that involve transitions between different spin states can be influenced by magnetic fields and by detecting the different product ratios, these organisms can perceive the direction of the magnetic field. The mechanism by which this is detected is not certain but it may also involve light stimuli." [GOC:ai, PMID:15886990, Wikipedia:Magnetoception]
synonym: "magnetoreception by chemical stimulus" EXACT []
synonym: "magnetoreception through chemical stimulus" EXACT []
synonym: "magnetoreception, sensory perception of chemical stimulus" EXACT []
synonym: "magnetoreception, using chemical stimulus" EXACT [GOC:dph, GOC:tb]
is_a: GO:0007606 ! sensory perception of chemical stimulus
is_a: GO:0050958 ! magnetoreception

[Term]
id: GO:0050978
name: magnetoreception by sensory perception of electrical stimulus
namespace: biological_process
def: "The series of events required for an organism to receive an electrical stimulus relating to a magnetic field, convert it to a molecular signal, and recognize and characterize the signal. Movement in a magnetic field results in an induced electric field, which can be perceived by organisms such as elasmobranch fish." [GOC:ai, PMID:15886990, Wikipedia:Magnetoception]
synonym: "magnetoreception by electrical stimulus" EXACT []
synonym: "magnetoreception through electrical stimulus" EXACT []
synonym: "magnetoreception, sensory perception of electrical stimulus" EXACT []
synonym: "magnetoreception, using electrical stimulus" EXACT [GOC:dph, GOC:tb]
is_a: GO:0050952 ! sensory perception of electrical stimulus
is_a: GO:0050958 ! magnetoreception

[Term]
id: GO:0050979
name: magnetoreception by sensory perception of mechanical stimulus
namespace: biological_process
def: "The series of events required for an organism to receive a mechanical stimulus relating to a magnetic field, convert it to a molecular signal, and recognize and characterize the signal. A magnetic field exerts a torque on a ferromagnetic material (e.g. magnetite) or on a material with diamagnetic anisotropy; organisms that can detect this torque can use it to determine the orientation of the magnetic field." [GOC:ai, PMID:15886990, Wikipedia:Magnetoception]
synonym: "magnetoreception through mechanical stimulus" EXACT []
synonym: "magnetoreception, sensory perception of mechanical stimulus" EXACT []
synonym: "magnetoreception, using mechanical stimulus" EXACT [GOC:dph, GOC:tb]
is_a: GO:0050954 ! sensory perception of mechanical stimulus
is_a: GO:0050958 ! magnetoreception

[Term]
id: GO:0050980
name: detection of light stimulus involved in magnetoreception
namespace: biological_process
def: "The series of events involved in magnetoception in which a light stimulus is received and converted into a molecular signal. Downstream processing of the light information in addition to other sensory data allows organisms to perceive the orientation of a magnetic field." [GOC:ai, GOC:dos, PMID:15886990, Wikipedia:Magnetoception]
synonym: "magnetoreception, detection of light stimulus" EXACT []
synonym: "magnetoreception, sensory detection of light stimulus" EXACT []
synonym: "magnetoreception, sensory transduction of light stimulus" EXACT []
synonym: "sensory detection of light stimulus during magnetoreception" EXACT []
synonym: "sensory transduction of light stimulus during magnetoreception" EXACT []
is_a: GO:0050962 ! detection of light stimulus involved in sensory perception
intersection_of: GO:0009583 ! detection of light stimulus
intersection_of: part_of GO:0050958 ! magnetoreception
relationship: part_of GO:0050958 ! magnetoreception

[Term]
id: GO:0050981
name: detection of electrical stimulus
namespace: biological_process
def: "The series of events by which an electrical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]
is_a: GO:0009582 ! detection of abiotic stimulus
is_a: GO:0051602 ! response to electrical stimulus

[Term]
id: GO:0050982
name: detection of mechanical stimulus
namespace: biological_process
def: "The series of events by which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]
is_a: GO:0009581 ! detection of external stimulus
is_a: GO:0009582 ! detection of abiotic stimulus
is_a: GO:0009612 ! response to mechanical stimulus

[Term]
id: GO:0050983
name: deoxyhypusine biosynthetic process from spermidine
namespace: biological_process
def: "The chemical reactions resulting in the formation of deoxyhypusine from spermidine by the enzyme [eIF-5A]-deoxyhypusine synthase. The reaction occurs in four steps: 1. spermidine + NAD+ = dehydrospermidine + NADH + H+; 2. dehydrospermidine + [enzyme]-lysine = 1,3-diaminopropane + [enzyme]-lysine-N6=CH(CH2)3NH2; 3. [enzyme]-lysine-N6=CH(CH2)3NH2 = [eIF-5A]-lysine-N6=CH(CH2)3NH2; 4. [eIF-5A]-lysine-N6=CH(CH2)3NH2 + NADH + H+ = [eIF-5A]-deoxyhypusine + NAD+." [MetaCyc:1.1.1.249-RXN]
comment: Note that this reaction is catalyzed by a single enzyme but since it has multiple steps, it appears in the process ontology.
subset: gosubset_prok
synonym: "(4-aminobutyl)lysine synthase activity" RELATED [EC:2.5.1.46]
synonym: "[eIF-5A]-deoxyhypusine synthase activity" RELATED [EC:2.5.1.46]
synonym: "deoxyhypusine anabolism from spermidine, using deoxyhypusine synthase" EXACT []
synonym: "deoxyhypusine biosynthesis from spermidine, using deoxyhypusine synthase" EXACT []
synonym: "deoxyhypusine biosynthetic process from spermidine, using deoxyhypusine synthase" EXACT []
synonym: "deoxyhypusine formation from spermidine, using deoxyhypusine synthase" EXACT []
synonym: "spermidine breakdown to deoxyhypusine, using deoxyhypusine synthase" EXACT []
synonym: "spermidine catabolic process to deoxyhypusine, using deoxyhypusine synthase" EXACT []
synonym: "spermidine degradation to deoxyhypusine, using deoxyhypusine synthase" EXACT []
xref: EC:2.5.1.46
xref: MetaCyc:2.5.1.46-RXN
is_a: GO:0042398 ! cellular modified amino acid biosynthetic process
is_a: GO:0044712 ! single-organism catabolic process
is_a: GO:0046203 ! spermidine catabolic process
is_a: GO:1901607 ! alpha-amino acid biosynthetic process

[Term]
id: GO:0050984
name: peptidyl-serine sulfation
namespace: biological_process
def: "The sulfation of peptidyl-serine to form peptidyl-O-sulfo-L-serine." [RESID:AA0361]
subset: gosubset_prok
xref: RESID:AA0361
is_a: GO:0006477 ! protein sulfation
is_a: GO:0018209 ! peptidyl-serine modification

[Term]
id: GO:0050985
name: peptidyl-threonine sulfation
namespace: biological_process
def: "The sulfation of peptidyl-threonine to form peptidyl-O-sulfo-L-threonine." [RESID:AA0362]
subset: gosubset_prok
xref: RESID:AA0362
is_a: GO:0006477 ! protein sulfation
is_a: GO:0018210 ! peptidyl-threonine modification

[Term]
id: GO:0050986
name: isopeptide cross-linking via N-(L-isoglutamyl)-glycine
namespace: biological_process
def: "The formation of an isopeptide cross-link between peptidyl-glutamate and peptidyl-glycine to produce N-(L-isoglutamyl)-glycine, as found in the antibiotic microcin J25." [PMID:14531691, RESID:AA0360]
subset: gosubset_prok
xref: RESID:AA0360
is_a: GO:0018200 ! peptidyl-glutamic acid modification
is_a: GO:0018201 ! peptidyl-glycine modification
is_a: GO:0018262 ! isopeptide cross-linking

[Term]
id: GO:0050987
name: enzyme active site formation via O-sulfo-L-serine
namespace: biological_process
def: "The transient sulfation of peptidyl-serine to form O-sulfo-L-serine." [RESID:AA0361]
subset: gosubset_prok
xref: RESID:AA0361
is_a: GO:0018307 ! enzyme active site formation
is_a: GO:0050984 ! peptidyl-serine sulfation

[Term]
id: GO:0050988
name: N-terminal peptidyl-methionine carboxylation
namespace: biological_process
def: "The carboxylation of the N-terminal methionine of proteins to form the derivative N-carboxy-L-methionine." [RESID:AA0363]
subset: gosubset_prok
xref: RESID:AA0363
is_a: GO:0018206 ! peptidyl-methionine modification
is_a: GO:0050989 ! N-terminal protein amino acid carboxylation

[Term]
id: GO:0050989
name: N-terminal protein amino acid carboxylation
namespace: biological_process
def: "The carboxylation of the N-terminal amino acid of proteins." [GOC:ai]
subset: gosubset_prok
is_a: GO:0031365 ! N-terminal protein amino acid modification

[Term]
id: GO:0050990
name: N-terminal protein amino acid carbamoylation
namespace: biological_process
def: "The carbamoylation of the N-terminal amino acid of proteins." [GOC:ai]
subset: gosubset_prok
synonym: "N-terminal protein amino acid carbamylation" EXACT []
is_a: GO:0031365 ! N-terminal protein amino acid modification

[Term]
id: GO:0050991
name: enzyme active site formation via O-sulfo-L-threonine
namespace: biological_process
def: "The transient sulfation of peptidyl-threonine to form O-sulfo-L-threonine." [RESID:AA0362]
subset: gosubset_prok
xref: RESID:AA0362
is_a: GO:0018307 ! enzyme active site formation
is_a: GO:0050985 ! peptidyl-threonine sulfation

[Term]
id: GO:0050992
name: dimethylallyl diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dimethylallyl diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "dimethylallyl diphosphate anabolism" EXACT []
synonym: "dimethylallyl diphosphate biosynthesis" EXACT []
synonym: "dimethylallyl diphosphate formation" EXACT []
synonym: "dimethylallyl diphosphate synthesis" EXACT []
synonym: "dimethylallyl pyrophosphate biosynthesis" EXACT []
synonym: "dimethylallyl pyrophosphate biosynthetic process" EXACT []
synonym: "DPP biosynthesis" EXACT []
synonym: "DPP biosynthetic process" EXACT []
is_a: GO:0008654 ! phospholipid biosynthetic process
is_a: GO:0050993 ! dimethylallyl diphosphate metabolic process

[Term]
id: GO:0050993
name: dimethylallyl diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dimethylallyl diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "dimethylallyl diphosphate metabolism" EXACT []
synonym: "dimethylallyl pyrophosphate metabolic process" EXACT []
synonym: "dimethylallyl pyrophosphate metabolism" EXACT []
synonym: "DPP metabolic process" EXACT []
synonym: "DPP metabolism" EXACT []
is_a: GO:0006644 ! phospholipid metabolic process

[Term]
id: GO:0050994
name: regulation of lipid catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of lipids." [GOC:ai]
synonym: "regulation of lipid breakdown" EXACT []
synonym: "regulation of lipid catabolism" EXACT []
synonym: "regulation of lipid degradation" EXACT []
is_a: GO:0009894 ! regulation of catabolic process
is_a: GO:0019216 ! regulation of lipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016042 ! lipid catabolic process
relationship: regulates GO:0016042 ! lipid catabolic process

[Term]
id: GO:0050995
name: negative regulation of lipid catabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids." [GOC:ai]
synonym: "down regulation of lipid catabolic process" EXACT []
synonym: "down-regulation of lipid catabolic process" EXACT []
synonym: "downregulation of lipid catabolic process" EXACT []
synonym: "inhibition of lipid catabolic process" NARROW []
synonym: "negative regulation of lipid breakdown" EXACT []
synonym: "negative regulation of lipid catabolism" EXACT []
synonym: "negative regulation of lipid degradation" EXACT []
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0045833 ! negative regulation of lipid metabolic process
is_a: GO:0050994 ! regulation of lipid catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016042 ! lipid catabolic process
relationship: negatively_regulates GO:0016042 ! lipid catabolic process

[Term]
id: GO:0050996
name: positive regulation of lipid catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids." [GOC:ai]
synonym: "activation of lipid catabolic process" NARROW []
synonym: "positive regulation of lipid breakdown" EXACT []
synonym: "positive regulation of lipid catabolism" EXACT []
synonym: "positive regulation of lipid degradation" EXACT []
synonym: "stimulation of lipid catabolic process" NARROW []
synonym: "up regulation of lipid catabolic process" EXACT []
synonym: "up-regulation of lipid catabolic process" EXACT []
synonym: "upregulation of lipid catabolic process" EXACT []
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0045834 ! positive regulation of lipid metabolic process
is_a: GO:0050994 ! regulation of lipid catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016042 ! lipid catabolic process
relationship: positively_regulates GO:0016042 ! lipid catabolic process

[Term]
id: GO:0050997
name: quaternary ammonium group binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a quaternary ammonium group, including glycine betaine, choline, carnitine and proline. A quaternary ammonium group is any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups." [GOC:ai]
subset: gosubset_prok
synonym: "quaternary amine binding" EXACT []
is_a: GO:0005488 ! binding

[Term]
id: GO:0050998
name: nitric-oxide synthase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the enzyme nitric-oxide synthase." [GOC:ai]
synonym: "NOS binding" EXACT []
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0050999
name: regulation of nitric-oxide synthase activity
namespace: biological_process
def: "Any process that modulates the activity of the enzyme nitric-oxide synthase." [GOC:ai]
subset: gosubset_prok
synonym: "nitric-oxide synthase regulator" EXACT []
synonym: "NOS regulator" EXACT []
synonym: "regulation of NOS activity" EXACT []
xref: Reactome:REACT_102045 "eNOS activation, Canis familiaris"
xref: Reactome:REACT_104058 "NOSIP mediated eNOS trafficking, Canis familiaris"
xref: Reactome:REACT_105771 "NOSTRIN mediated eNOS trafficking, Mus musculus"
xref: Reactome:REACT_106896 "NOSTRIN mediated eNOS trafficking, Sus scrofa"
xref: Reactome:REACT_107269 "NOSTRIN mediated eNOS trafficking, Canis familiaris"
xref: Reactome:REACT_110353 "eNOS activation and regulation, Rattus norvegicus"
xref: Reactome:REACT_112087 "eNOS activation and regulation, Taeniopygia guttata"
xref: Reactome:REACT_114898 "eNOS activation, Taeniopygia guttata"
xref: Reactome:REACT_12389 "eNOS activation and regulation, Homo sapiens"
xref: Reactome:REACT_12477 "eNOS activation, Homo sapiens"
xref: Reactome:REACT_12510 "NOSIP mediated eNOS trafficking, Homo sapiens"
xref: Reactome:REACT_12541 "NOSTRIN mediated eNOS trafficking, Homo sapiens"
xref: Reactome:REACT_31862 "NOSIP mediated eNOS trafficking, Rattus norvegicus"
xref: Reactome:REACT_32061 "NOSIP mediated eNOS trafficking, Mus musculus"
xref: Reactome:REACT_77988 "NOSTRIN mediated eNOS trafficking, Rattus norvegicus"
xref: Reactome:REACT_79216 "eNOS activation, Mus musculus"
xref: Reactome:REACT_79354 "eNOS activation and regulation, Danio rerio"
xref: Reactome:REACT_80459 "eNOS activation, Bos taurus"
xref: Reactome:REACT_81129 "NOSTRIN mediated eNOS trafficking, Xenopus tropicalis"
xref: Reactome:REACT_81422 "NOSTRIN mediated eNOS trafficking, Bos taurus"
xref: Reactome:REACT_82078 "eNOS activation, Sus scrofa"
xref: Reactome:REACT_83935 "eNOS activation and regulation, Mus musculus"
xref: Reactome:REACT_84064 "eNOS activation and regulation, Sus scrofa"
xref: Reactome:REACT_85809 "eNOS activation, Rattus norvegicus"
xref: Reactome:REACT_87479 "NOSIP mediated eNOS trafficking, Xenopus tropicalis"
xref: Reactome:REACT_89374 "eNOS activation and regulation, Xenopus tropicalis"
xref: Reactome:REACT_90081 "eNOS activation, Xenopus tropicalis"
xref: Reactome:REACT_90181 "NOSIP mediated eNOS trafficking, Sus scrofa"
xref: Reactome:REACT_93737 "eNOS activation and regulation, Canis familiaris"
xref: Reactome:REACT_95559 "NOSTRIN mediated eNOS trafficking, Danio rerio"
xref: Reactome:REACT_96914 "NOSIP mediated eNOS trafficking, Bos taurus"
xref: Reactome:REACT_98362 "eNOS activation and regulation, Bos taurus"
is_a: GO:0032768 ! regulation of monooxygenase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004517 ! nitric-oxide synthase activity
relationship: regulates GO:0004517 ! nitric-oxide synthase activity

[Term]
id: GO:0051000
name: positive regulation of nitric-oxide synthase activity
namespace: biological_process
def: "Any process that activates or increases the activity of the enzyme nitric-oxide synthase." [GOC:ai]
subset: gosubset_prok
synonym: "activation of nitric-oxide synthase activity" NARROW []
synonym: "nitric-oxide synthase activator" EXACT []
synonym: "NOS activator" EXACT []
synonym: "positive regulation of NOS activity" EXACT []
synonym: "stimulation of nitric-oxide synthase activity" NARROW []
synonym: "up regulation of nitric-oxide synthase activity" EXACT []
synonym: "up-regulation of nitric-oxide synthase activity" EXACT []
synonym: "upregulation of nitric-oxide synthase activity" EXACT []
is_a: GO:0032770 ! positive regulation of monooxygenase activity
is_a: GO:0050999 ! regulation of nitric-oxide synthase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004517 ! nitric-oxide synthase activity
relationship: positively_regulates GO:0004517 ! nitric-oxide synthase activity

[Term]
id: GO:0051001
name: negative regulation of nitric-oxide synthase activity
namespace: biological_process
def: "Any process that stops or reduces the activity of the enzyme nitric-oxide synthase." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of nitric-oxide synthase activity" EXACT []
synonym: "down-regulation of nitric-oxide synthase activity" EXACT []
synonym: "downregulation of nitric-oxide synthase activity" EXACT []
synonym: "inhibition of nitric-oxide synthase activity" NARROW []
synonym: "negative regulation of NOS activity" EXACT []
synonym: "nitric-oxide synthase inhibitor" NARROW []
synonym: "NOS inhibitor" NARROW []
is_a: GO:0032769 ! negative regulation of monooxygenase activity
is_a: GO:0050999 ! regulation of nitric-oxide synthase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004517 ! nitric-oxide synthase activity
relationship: negatively_regulates GO:0004517 ! nitric-oxide synthase activity

[Term]
id: GO:0051002
name: ligase activity, forming nitrogen-metal bonds
namespace: molecular_function
def: "Catalysis of the joining of a metal ion to a molecule via a nitrogen-metal bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.6, GOC:mah]
subset: gosubset_prok
xref: EC:6.6
is_a: GO:0016874 ! ligase activity

[Term]
id: GO:0051003
name: ligase activity, forming nitrogen-metal bonds, forming coordination complexes
namespace: molecular_function
def: "Catalysis of the ligation of two substances via a nitrogen-metal bond, forming a coordination complex." [EC:6.6.1.-]
subset: gosubset_prok
xref: EC:6.6.1
is_a: GO:0051002 ! ligase activity, forming nitrogen-metal bonds

[Term]
id: GO:0051004
name: regulation of lipoprotein lipase activity
namespace: biological_process
def: "Any process that modulates the activity of the enzyme lipoprotein lipase." [GOC:ai]
subset: gosubset_prok
is_a: GO:0060191 ! regulation of lipase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004465 ! lipoprotein lipase activity
relationship: regulates GO:0004465 ! lipoprotein lipase activity

[Term]
id: GO:0051005
name: negative regulation of lipoprotein lipase activity
namespace: biological_process
def: "Any process that stops or reduces the activity of the enzyme lipoprotein lipase." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of lipoprotein lipase activity" EXACT []
synonym: "down-regulation of lipoprotein lipase activity" EXACT []
synonym: "downregulation of lipoprotein lipase activity" EXACT []
synonym: "inhibition of lipoprotein lipase activity" NARROW []
is_a: GO:0051004 ! regulation of lipoprotein lipase activity
is_a: GO:0060192 ! negative regulation of lipase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004465 ! lipoprotein lipase activity
relationship: negatively_regulates GO:0004465 ! lipoprotein lipase activity

[Term]
id: GO:0051006
name: positive regulation of lipoprotein lipase activity
namespace: biological_process
def: "Any process that activates or increases the activity of the enzyme lipoprotein lipase." [GOC:ai]
subset: gosubset_prok
synonym: "activation of lipoprotein lipase activity" NARROW []
synonym: "stimulation of lipoprotein lipase activity" NARROW []
synonym: "up regulation of lipoprotein lipase activity" EXACT []
synonym: "up-regulation of lipoprotein lipase activity" EXACT []
synonym: "upregulation of lipoprotein lipase activity" EXACT []
is_a: GO:0051004 ! regulation of lipoprotein lipase activity
is_a: GO:0061365 ! positive regulation of triglyceride lipase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004465 ! lipoprotein lipase activity
relationship: positively_regulates GO:0004465 ! lipoprotein lipase activity

[Term]
id: GO:0051007
name: squalene-hopene cyclase activity
namespace: molecular_function
def: "Catalysis of the reaction: squalene = hop-22(29)-ene." [EC:5.4.99.17]
subset: gosubset_prok
synonym: "squalene mutase (cyclizing)" EXACT [EC:5.4.99.17]
synonym: "squalene:hopene cyclase activity" EXACT [PMID:18033581]
xref: EC:5.4.99.17
xref: MetaCyc:5.4.99.17-RXN
is_a: GO:0016866 ! intramolecular transferase activity
is_a: GO:0034072 ! squalene cyclase activity

[Term]
id: GO:0051008
name: Hsp27 protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with Hsp27 proteins, a lightweight heat shock protein." [GOC:ai]
is_a: GO:0031072 ! heat shock protein binding

[Term]
id: GO:0051009
name: O-acetylhomoserine sulfhydrylase activity
namespace: molecular_function
def: "Catalysis of the reaction: O-acetyl-L-homoserine + hydrogen sulfide = homocysteine + acetate." [MetaCyc:ACETYLHOMOSER-CYS-RXN, RHEA:27825]
xref: MetaCyc:ACETYLHOMOSER-CYS-RXN
is_a: GO:0016835 ! carbon-oxygen lyase activity

[Term]
id: GO:0051010
name: microtubule plus-end binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the plus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826]
is_a: GO:0008017 ! microtubule binding

[Term]
id: GO:0051011
name: microtubule minus-end binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the minus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826]
is_a: GO:0008017 ! microtubule binding

[Term]
id: GO:0051012
name: microtubule sliding
namespace: biological_process
def: "The movement of one microtubule along another microtubule." [PMID:14557818, PMID:14614826]
synonym: "microtubule translocation" EXACT []
is_a: GO:0007018 ! microtubule-based movement

[Term]
id: GO:0051013
name: microtubule severing
namespace: biological_process
def: "The process in which a microtubule is broken down into smaller segments." [GOC:ai, PMID:14657234]
synonym: "microtubule severing activity" RELATED []
is_a: GO:0007017 ! microtubule-based process

[Term]
id: GO:0051014
name: actin filament severing
namespace: biological_process
def: "The process in which an actin filament is broken down into smaller filaments." [GOC:ai, PMID:14657234]
synonym: "actin filament severing activity" RELATED []
synonym: "barbed-end actin capping/severing activity" RELATED []
synonym: "F-actin severing" EXACT []
is_a: GO:0030029 ! actin filament-based process

[Term]
id: GO:0051015
name: actin filament binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]
synonym: "actin cross-linking activity" RELATED []
synonym: "F-actin binding" EXACT []
is_a: GO:0003779 ! actin binding
is_a: GO:0032403 ! protein complex binding

[Term]
id: GO:0051016
name: barbed-end actin filament capping
namespace: biological_process
def: "The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X]
synonym: "barbed-end actin capping activity" EXACT []
synonym: "barbed-end F-actin capping activity" EXACT []
synonym: "plus-end actin filament capping activity" EXACT []
synonym: "plus-end F-actin capping activity" EXACT []
is_a: GO:0051693 ! actin filament capping

[Term]
id: GO:0051017
name: actin filament bundle assembly
namespace: biological_process
alt_id: GO:0045011
def: "The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:ai]
synonym: "actin bundling activity" RELATED []
synonym: "actin cable assembly" RELATED [GOC:mah]
synonym: "actin cable formation" RELATED [GOC:mah]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0061572 ! actin filament bundle organization

[Term]
id: GO:0051018
name: protein kinase A binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any subunit of protein kinase A." [GOC:ai]
comment: Note that this term is a direct child of 'protein binding ; GO:0005515' because it encompasses binding to either the catalytic or regulatory subunit of protein kinase A, and the latter does not have kinase activity.
synonym: "PKA binding" EXACT []
synonym: "protein kinase A anchoring activity" RELATED []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0051019
name: mitogen-activated protein kinase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a mitogen-activated protein kinase." [GOC:ai]
synonym: "MAP kinase binding" EXACT []
synonym: "MAP-kinase anchoring activity" RELATED []
synonym: "MAPK binding" EXACT []
is_a: GO:0019901 ! protein kinase binding

[Term]
id: GO:0051020
name: GTPase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a GTPase, any enzyme that catalyzes the hydrolysis of GTP." [GOC:ai]
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0051021
name: GDP-dissociation inhibitor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a GDP-dissociation inhibitor protein." [GOC:ai]
synonym: "GDI binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0051022
name: Rho GDP-dissociation inhibitor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a Rho GDP-dissociation inhibitor protein." [GOC:ai]
synonym: "Rho GDI binding" EXACT []
is_a: GO:0051021 ! GDP-dissociation inhibitor binding

[Term]
id: GO:0051023
name: regulation of immunoglobulin secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of immunoglobulins from a cell." [GOC:ai]
synonym: "regulation of antibody secretion" EXACT []
is_a: GO:0002637 ! regulation of immunoglobulin production
is_a: GO:0050708 ! regulation of protein secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048305 ! immunoglobulin secretion
relationship: regulates GO:0048305 ! immunoglobulin secretion

[Term]
id: GO:0051024
name: positive regulation of immunoglobulin secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of immunoglobulins from a cell." [GOC:ai]
synonym: "activation of immunoglobulin secretion" NARROW []
synonym: "positive regulation of antibody secretion" EXACT []
synonym: "stimulation of immunoglobulin secretion" NARROW []
synonym: "up regulation of immunoglobulin secretion" EXACT []
synonym: "up-regulation of immunoglobulin secretion" EXACT []
synonym: "upregulation of immunoglobulin secretion" EXACT []
is_a: GO:0002639 ! positive regulation of immunoglobulin production
is_a: GO:0050714 ! positive regulation of protein secretion
is_a: GO:0051023 ! regulation of immunoglobulin secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048305 ! immunoglobulin secretion
relationship: positively_regulates GO:0048305 ! immunoglobulin secretion

[Term]
id: GO:0051025
name: negative regulation of immunoglobulin secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of immunoglobulins from a cell." [GOC:ai]
synonym: "down regulation of immunoglobulin secretion" EXACT []
synonym: "down-regulation of immunoglobulin secretion" EXACT []
synonym: "downregulation of immunoglobulin secretion" EXACT []
synonym: "inhibition of immunoglobulin secretion" NARROW []
synonym: "negative regulation of antibody secretion" EXACT []
is_a: GO:0002638 ! negative regulation of immunoglobulin production
is_a: GO:0050709 ! negative regulation of protein secretion
is_a: GO:0051023 ! regulation of immunoglobulin secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048305 ! immunoglobulin secretion
relationship: negatively_regulates GO:0048305 ! immunoglobulin secretion

[Term]
id: GO:0051026
name: chiasma assembly
namespace: biological_process
def: "The cell cycle process in which a connection between chromatids assembles, indicating where an exchange of homologous segments has taken place by the crossing-over of non-sister chromatids." [http://www.onelook.com]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0007129 ! synapsis
relationship: part_of GO:0007131 ! reciprocal meiotic recombination

[Term]
id: GO:0051027
name: DNA transport
namespace: biological_process
def: "The directed movement of RNA, deoxyribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
is_a: GO:0050657 ! nucleic acid transport

[Term]
id: GO:0051028
name: mRNA transport
namespace: biological_process
def: "The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0050658 ! RNA transport

[Term]
id: GO:0051029
name: rRNA transport
namespace: biological_process
def: "The directed movement of rRNA, ribosomal ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0044765 ! single-organism transport
is_a: GO:0050658 ! RNA transport

[Term]
id: GO:0051030
name: snRNA transport
namespace: biological_process
def: "The directed movement of snRNA, small nuclear ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0044765 ! single-organism transport
is_a: GO:0050658 ! RNA transport

[Term]
id: GO:0051031
name: tRNA transport
namespace: biological_process
def: "The directed movement of tRNA, transfer ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0044765 ! single-organism transport
is_a: GO:0050658 ! RNA transport

[Term]
id: GO:0051032
name: nucleic acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of nucleic acids from one side of a membrane to the other. Nucleic acids are single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information." [GOC:ai]
is_a: GO:0015932 ! nucleobase-containing compound transmembrane transporter activity
is_a: GO:0022884 ! macromolecule transmembrane transporter activity
relationship: part_of GO:0050657 ! nucleic acid transport

[Term]
id: GO:0051033
name: RNA transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of RNA, ribonucleic acid, from one side of a membrane to the other." [GOC:ai]
xref: Reactome:REACT_102675 "Exportin complex translocates pre-miRNA to cytosol, Rattus norvegicus"
xref: Reactome:REACT_104565 "Exportin complex translocates pre-miRNA to cytosol, Canis familiaris"
xref: Reactome:REACT_106664 "Exportin complex translocates pre-miRNA to cytosol, Drosophila melanogaster"
xref: Reactome:REACT_107340 "Exportin complex translocates pre-miRNA to cytosol, Taeniopygia guttata"
xref: Reactome:REACT_12608 "Exportin complex translocates pre-miRNA to cytosol, Homo sapiens"
xref: Reactome:REACT_79194 "Exportin complex translocates pre-miRNA to cytosol, Schizosaccharomyces pombe"
xref: Reactome:REACT_83711 "Exportin complex translocates pre-miRNA to cytosol, Dictyostelium discoideum"
xref: Reactome:REACT_85733 "Exportin complex translocates pre-miRNA to cytosol, Mus musculus"
xref: Reactome:REACT_86714 "Exportin complex translocates pre-miRNA to cytosol, Danio rerio"
xref: Reactome:REACT_89206 "Exportin complex translocates pre-miRNA to cytosol, Saccharomyces cerevisiae"
xref: Reactome:REACT_91905 "Exportin complex translocates pre-miRNA to cytosol, Arabidopsis thaliana"
xref: Reactome:REACT_94411 "Exportin complex translocates pre-miRNA to cytosol, Gallus gallus"
xref: Reactome:REACT_95358 "Exportin complex translocates pre-miRNA to cytosol, Sus scrofa"
xref: Reactome:REACT_95753 "Exportin complex translocates pre-miRNA to cytosol, Xenopus tropicalis"
xref: Reactome:REACT_98122 "Exportin complex translocates pre-miRNA to cytosol, Oryza sativa"
is_a: GO:0051032 ! nucleic acid transmembrane transporter activity
relationship: part_of GO:0050658 ! RNA transport

[Term]
id: GO:0051034
name: tRNA transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of tRNA, transfer ribonucleic acid, from one side of a membrane to the other." [GOC:ai]
is_a: GO:0051033 ! RNA transmembrane transporter activity
relationship: part_of GO:0051031 ! tRNA transport

[Term]
id: GO:0051035
name: DNA transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of DNA, deoxyribonucleic acid, from one side of a membrane to the other." [GOC:ai]
is_a: GO:0051032 ! nucleic acid transmembrane transporter activity
relationship: part_of GO:0051027 ! DNA transport

[Term]
id: GO:0051036
name: regulation of endosome size
namespace: biological_process
def: "Any process that modulates the volume of an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis." [GOC:ai]
synonym: "endosome enlargement" RELATED []
is_a: GO:0032535 ! regulation of cellular component size

[Term]
id: GO:0051037
name: regulation of transcription involved in meiotic cell cycle
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription as part of a meiotic cell cycle." [GOC:go_curators]
synonym: "meiotic regulation of transcription" EXACT []
synonym: "regulation of transcription, meiotic" EXACT [GOC:mah]
is_a: GO:0006355 ! regulation of transcription, DNA-templated
is_a: GO:0022414 ! reproductive process
intersection_of: GO:0006355 ! regulation of transcription, DNA-templated
intersection_of: part_of GO:0051321 ! meiotic cell cycle
relationship: part_of GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0051038
name: negative regulation of transcription involved in meiotic cell cycle
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription involved in the meiotic cell cycle." [GOC:ai]
synonym: "down regulation of transcription during meiosis" EXACT [GOC:mah]
synonym: "down-regulation of transcription during meiosis" EXACT [GOC:mah]
synonym: "downregulation of transcription during meiosis" EXACT [GOC:mah]
synonym: "inhibition of transcription during meiosis" NARROW [GOC:mah]
synonym: "meiotic repression of transcription" EXACT []
synonym: "negative regulation of meiotic transcription" EXACT []
synonym: "negative regulation of transcription, meiotic" EXACT [GOC:mah]
is_a: GO:0045892 ! negative regulation of transcription, DNA-templated
is_a: GO:0051037 ! regulation of transcription involved in meiotic cell cycle

[Term]
id: GO:0051039
name: positive regulation of transcription involved in meiotic cell cycle
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transcription as part of a meiotic cell cycle." [GOC:ai]
synonym: "activation of transcription during meiosis" NARROW [GOC:mah]
synonym: "positive regulation of meiotic transcription" EXACT []
synonym: "positive regulation of transcription, meiotic" EXACT [GOC:mah]
synonym: "stimulation of transcription during meiosis" NARROW [GOC:mah]
synonym: "up regulation of transcription during meiosis" EXACT [GOC:mah]
synonym: "up-regulation of transcription during meiosis" EXACT [GOC:mah]
synonym: "upregulation of transcription during meiosis" EXACT [GOC:mah]
is_a: GO:0045893 ! positive regulation of transcription, DNA-templated
is_a: GO:0051037 ! regulation of transcription involved in meiotic cell cycle

[Term]
id: GO:0051040
name: regulation of calcium-independent cell-cell adhesion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the attachment of one cell to another cell via adhesion molecules that do not require the presence of calcium for the interaction." [GOC:ai]
is_a: GO:0022407 ! regulation of cell-cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016338 ! calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
relationship: regulates GO:0016338 ! calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules

[Term]
id: GO:0051041
name: positive regulation of calcium-independent cell-cell adhesion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of calcium-independent cell-cell adhesion." [GOC:ai]
synonym: "activation of calcium-independent cell-cell adhesion" NARROW []
synonym: "stimulation of calcium-independent cell-cell adhesion" NARROW []
synonym: "up regulation of calcium-independent cell-cell adhesion" EXACT []
synonym: "up-regulation of calcium-independent cell-cell adhesion" EXACT []
synonym: "upregulation of calcium-independent cell-cell adhesion" EXACT []
is_a: GO:0022409 ! positive regulation of cell-cell adhesion
is_a: GO:0051040 ! regulation of calcium-independent cell-cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016338 ! calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
relationship: positively_regulates GO:0016338 ! calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules

[Term]
id: GO:0051042
name: negative regulation of calcium-independent cell-cell adhesion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of calcium-independent cell-cell adhesion." [GOC:ai]
synonym: "down regulation of calcium-independent cell-cell adhesion" EXACT []
synonym: "down-regulation of calcium-independent cell-cell adhesion" EXACT []
synonym: "downregulation of calcium-independent cell-cell adhesion" EXACT []
synonym: "inhibition of calcium-independent cell-cell adhesion" NARROW []
is_a: GO:0022408 ! negative regulation of cell-cell adhesion
is_a: GO:0051040 ! regulation of calcium-independent cell-cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016338 ! calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
relationship: negatively_regulates GO:0016338 ! calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules

[Term]
id: GO:0051043
name: regulation of membrane protein ectodomain proteolysis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain)." [GOC:ai]
subset: gosubset_prok
is_a: GO:0030162 ! regulation of proteolysis
is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:0032268 ! regulation of cellular protein metabolic process
is_a: GO:0042176 ! regulation of protein catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006509 ! membrane protein ectodomain proteolysis
relationship: regulates GO:0006509 ! membrane protein ectodomain proteolysis

[Term]
id: GO:0051044
name: positive regulation of membrane protein ectodomain proteolysis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of membrane protein ectodomain peptidolysis." [GOC:ai]
subset: gosubset_prok
synonym: "activation of membrane protein ectodomain proteolysis" NARROW []
synonym: "stimulation of membrane protein ectodomain proteolysis" NARROW []
synonym: "up regulation of membrane protein ectodomain proteolysis" EXACT []
synonym: "up-regulation of membrane protein ectodomain proteolysis" EXACT []
synonym: "upregulation of membrane protein ectodomain proteolysis" EXACT []
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:0045732 ! positive regulation of protein catabolic process
is_a: GO:0045862 ! positive regulation of proteolysis
is_a: GO:0051043 ! regulation of membrane protein ectodomain proteolysis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006509 ! membrane protein ectodomain proteolysis
relationship: positively_regulates GO:0006509 ! membrane protein ectodomain proteolysis

[Term]
id: GO:0051045
name: negative regulation of membrane protein ectodomain proteolysis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of membrane protein ectodomain proteolysis." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of membrane protein ectodomain proteolysis" EXACT []
synonym: "down-regulation of membrane protein ectodomain proteolysis" EXACT []
synonym: "downregulation of membrane protein ectodomain proteolysis" EXACT []
synonym: "inhibition of membrane protein ectodomain proteolysis" NARROW []
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:0042177 ! negative regulation of protein catabolic process
is_a: GO:0045861 ! negative regulation of proteolysis
is_a: GO:0051043 ! regulation of membrane protein ectodomain proteolysis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006509 ! membrane protein ectodomain proteolysis
relationship: negatively_regulates GO:0006509 ! membrane protein ectodomain proteolysis

[Term]
id: GO:0051046
name: regulation of secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue." [GOC:ai]
subset: gosubset_prok
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0046903 ! secretion
relationship: regulates GO:0046903 ! secretion

[Term]
id: GO:0051047
name: positive regulation of secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue." [GOC:ai]
synonym: "activation of secretion" NARROW []
synonym: "stimulation of secretion" NARROW []
synonym: "up regulation of secretion" EXACT []
synonym: "up-regulation of secretion" EXACT []
synonym: "upregulation of secretion" EXACT []
is_a: GO:0051046 ! regulation of secretion
is_a: GO:0051050 ! positive regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0046903 ! secretion
relationship: positively_regulates GO:0046903 ! secretion

[Term]
id: GO:0051048
name: negative regulation of secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a substance from a cell or a tissue." [GOC:ai]
synonym: "down regulation of secretion" EXACT []
synonym: "down-regulation of secretion" EXACT []
synonym: "downregulation of secretion" EXACT []
synonym: "inhibition of secretion" NARROW []
is_a: GO:0051046 ! regulation of secretion
is_a: GO:0051051 ! negative regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0046903 ! secretion
relationship: negatively_regulates GO:0046903 ! secretion

[Term]
id: GO:0051049
name: regulation of transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: goslim_yeast
subset: gosubset_prok
is_a: GO:0032879 ! regulation of localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006810 ! transport
relationship: regulates GO:0006810 ! transport

[Term]
id: GO:0051050
name: positive regulation of transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "activation of transport" NARROW []
synonym: "stimulation of transport" NARROW []
synonym: "up regulation of transport" EXACT []
synonym: "up-regulation of transport" EXACT []
synonym: "upregulation of transport" EXACT []
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006810 ! transport
relationship: positively_regulates GO:0006810 ! transport

[Term]
id: GO:0051051
name: negative regulation of transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of transport" EXACT []
synonym: "down-regulation of transport" EXACT []
synonym: "downregulation of transport" EXACT []
synonym: "inhibition of transport" NARROW []
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006810 ! transport
relationship: negatively_regulates GO:0006810 ! transport

[Term]
id: GO:0051052
name: regulation of DNA metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai]
subset: goslim_yeast
subset: gosubset_prok
synonym: "regulation of DNA metabolism" EXACT []
is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process
is_a: GO:0060255 ! regulation of macromolecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006259 ! DNA metabolic process
relationship: regulates GO:0006259 ! DNA metabolic process

[Term]
id: GO:0051053
name: negative regulation of DNA metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of DNA metabolic process" EXACT []
synonym: "down-regulation of DNA metabolic process" EXACT []
synonym: "downregulation of DNA metabolic process" EXACT []
synonym: "inhibition of DNA metabolic process" NARROW []
synonym: "negative regulation of DNA metabolism" EXACT []
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process
is_a: GO:0051052 ! regulation of DNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006259 ! DNA metabolic process
relationship: negatively_regulates GO:0006259 ! DNA metabolic process

[Term]
id: GO:0051054
name: positive regulation of DNA metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai]
subset: gosubset_prok
synonym: "activation of DNA metabolic process" NARROW []
synonym: "positive regulation of DNA metabolism" EXACT []
synonym: "stimulation of DNA metabolic process" NARROW []
synonym: "up regulation of DNA metabolic process" EXACT []
synonym: "up-regulation of DNA metabolic process" EXACT []
synonym: "upregulation of DNA metabolic process" EXACT []
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process
is_a: GO:0051052 ! regulation of DNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006259 ! DNA metabolic process
relationship: positively_regulates GO:0006259 ! DNA metabolic process

[Term]
id: GO:0051055
name: negative regulation of lipid biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of lipid biosynthetic process" EXACT []
synonym: "down-regulation of lipid biosynthetic process" EXACT []
synonym: "downregulation of lipid biosynthetic process" EXACT []
synonym: "inhibition of lipid biosynthetic process" NARROW []
synonym: "negative regulation of lipid anabolism" EXACT []
synonym: "negative regulation of lipid biosynthesis" EXACT []
synonym: "negative regulation of lipid formation" EXACT []
synonym: "negative regulation of lipid synthesis" EXACT []
synonym: "negative regulation of lipogenesis" EXACT [GOC:sl]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0045833 ! negative regulation of lipid metabolic process
is_a: GO:0046890 ! regulation of lipid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008610 ! lipid biosynthetic process
relationship: negatively_regulates GO:0008610 ! lipid biosynthetic process

[Term]
id: GO:0051056
name: regulation of small GTPase mediated signal transduction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]
synonym: "regulation of small GTPase-mediated signal transduction" EXACT []
xref: Reactome:REACT_101392 "Rho GTPase cycle, Canis familiaris"
xref: Reactome:REACT_105151 "Rho GTPase cycle, Xenopus tropicalis"
xref: Reactome:REACT_110059 "Rho GTPase cycle, Bos taurus"
xref: Reactome:REACT_11051 "Rho GTPase cycle, Homo sapiens"
xref: Reactome:REACT_28304 "Rho GTPase cycle, Taeniopygia guttata"
xref: Reactome:REACT_30809 "Rho GTPase cycle, Saccharomyces cerevisiae"
xref: Reactome:REACT_32940 "Rho GTPase cycle, Gallus gallus"
xref: Reactome:REACT_77671 "Rho GTPase cycle, Caenorhabditis elegans"
xref: Reactome:REACT_77929 "Rho GTPase cycle, Mus musculus"
xref: Reactome:REACT_78559 "Rho GTPase cycle, Arabidopsis thaliana"
xref: Reactome:REACT_82220 "Rho GTPase cycle, Drosophila melanogaster"
xref: Reactome:REACT_88001 "Rho GTPase cycle, Oryza sativa"
xref: Reactome:REACT_88549 "Rho GTPase cycle, Dictyostelium discoideum"
xref: Reactome:REACT_90249 "Rho GTPase cycle, Sus scrofa"
xref: Reactome:REACT_91095 "Rho GTPase cycle, Danio rerio"
xref: Reactome:REACT_92646 "Rho GTPase cycle, Rattus norvegicus"
xref: Reactome:REACT_99648 "Rho GTPase cycle, Schizosaccharomyces pombe"
is_a: GO:1902531 ! regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007264 ! small GTPase mediated signal transduction
relationship: regulates GO:0007264 ! small GTPase mediated signal transduction

[Term]
id: GO:0051057
name: positive regulation of small GTPase mediated signal transduction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:ai]
synonym: "activation of small GTPase mediated signal transduction" NARROW []
synonym: "positive regulation of small GTPase-mediated signal transduction" EXACT []
synonym: "stimulation of small GTPase mediated signal transduction" NARROW []
synonym: "up regulation of small GTPase mediated signal transduction" EXACT []
synonym: "up-regulation of small GTPase mediated signal transduction" EXACT []
synonym: "upregulation of small GTPase mediated signal transduction" EXACT []
is_a: GO:0051056 ! regulation of small GTPase mediated signal transduction
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007264 ! small GTPase mediated signal transduction
relationship: positively_regulates GO:0007264 ! small GTPase mediated signal transduction

[Term]
id: GO:0051058
name: negative regulation of small GTPase mediated signal transduction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:ai]
synonym: "down regulation of small GTPase mediated signal transduction" EXACT []
synonym: "down-regulation of small GTPase mediated signal transduction" EXACT []
synonym: "downregulation of small GTPase mediated signal transduction" EXACT []
synonym: "inhibition of small GTPase mediated signal transduction" NARROW []
synonym: "negative regulation of small GTPase-mediated signal transduction" EXACT []
is_a: GO:0051056 ! regulation of small GTPase mediated signal transduction
is_a: GO:1902532 ! negative regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007264 ! small GTPase mediated signal transduction
relationship: negatively_regulates GO:0007264 ! small GTPase mediated signal transduction

[Term]
id: GO:0051059
name: NF-kappaB binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters." [GOC:ai]
is_a: GO:0008134 ! transcription factor binding

[Term]
id: GO:0051060
name: pullulanase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1,6)-alpha-D-glucosidic linkages in pullulan (a linear polymer of alpha-(1,6)-linked maltotriose units) and in amylopectin and glycogen, and the a- and b-limit dextrins of amylopectin and glycogen." [EC:3.2.1.41]
subset: gosubset_prok
synonym: "alpha-dextrin endo-1,6-alpha-glucosidase activity" EXACT []
synonym: "amylopectin 6-glucanohydrolase activity" EXACT []
synonym: "bacterial debranching enzyme" RELATED [EC:3.2.1.41]
synonym: "debranching enzyme activity" BROAD [EC:3.2.1.41]
synonym: "limit dextrinase (erroneous)" BROAD [EC:3.2.1.41]
synonym: "pullulan 6-glucanohydrolase activity" EXACT []
synonym: "pullulan alpha-1,6-glucanohydrolase activity" EXACT [EC:3.2.1.41]
synonym: "R-enzyme" RELATED [EC:3.2.1.41]
xref: EC:3.2.1.41
xref: MetaCyc:RXN-1824
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0051061
name: ADP reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: dADP + thioredoxin disulfide + H2O = ADP + thioredoxin." [MetaCyc:ADPREDUCT-RXN]
synonym: "ADP reduction" RELATED []
xref: MetaCyc:ADPREDUCT-RXN
is_a: GO:0004748 ! ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor

[Term]
id: GO:0051062
name: UDP reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: dUDP + thioredoxin disulfide + H2O = UDP + thioredoxin." [MetaCyc:UDPREDUCT-RXN]
synonym: "UDP reduction" RELATED []
xref: MetaCyc:UDPREDUCT-RXN
is_a: GO:0004748 ! ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor

[Term]
id: GO:0051063
name: CDP reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: dCDP + thioredoxin disulfide + H2O = CDP + thioredoxin." [MetaCyc:CDPREDUCT-RXN]
synonym: "CDP reduction" RELATED []
xref: MetaCyc:CDPREDUCT-RXN
is_a: GO:0004748 ! ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor

[Term]
id: GO:0051064
name: TTP reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: dTTP + thioredoxin disulfide + H2O = TTP + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin." [MetaCyc:1.17.4.2-RXN]
synonym: "TTP reduction" RELATED []
xref: EC:1.17.4.-
is_a: GO:0008998 ! ribonucleoside-triphosphate reductase activity

[Term]
id: GO:0051065
name: CTP reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: dCTP + thioredoxin disulfide + H2O = CTP + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin." [MetaCyc:1.17.4.2-RXN]
synonym: "CTP reduction" RELATED []
xref: EC:1.17.4.-
is_a: GO:0008998 ! ribonucleoside-triphosphate reductase activity

[Term]
id: GO:0051066
name: dihydrobiopterin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a dihydrobiopterin, a reduced pteridine derivative related to folic acid; it acts as an electron carrier in tyrosine biosynthesis and its quinoid form is produced by oxidation of tetrahydrobiopterin in several biological hydroxylation reactions." [CHEBI:38797, http://www.onelook.com]
subset: gosubset_prok
synonym: "6,7-dihydrobiopterin metabolic process" NARROW [CHEBI:20680, GOC:curators]
synonym: "7,8-dihydrobiopterin metabolic process" NARROW [CHEBI:15375, GOC:curators]
synonym: "dihydrobiopterin reduction" NARROW [GOC:curators]
synonym: "dihydropterin metabolic process" EXACT [CHEBI:38797]
synonym: "dihydropterin metabolism" EXACT [GOC:curators]
is_a: GO:0042558 ! pteridine-containing compound metabolic process

[Term]
id: GO:0051067
name: dihydropteridine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 6,7-dihydropteridine, a bicyclic compound with the formula C6H6N4." [CHEBI:30156, GOC:ai]
subset: gosubset_prok
synonym: "6,7-dihydropteridine metabolic process" EXACT [CHEBI:30156, GOC:curators]
synonym: "dihydropteridine metabolism" EXACT []
synonym: "dihydropteridine reduction" NARROW []
is_a: GO:0042558 ! pteridine-containing compound metabolic process

[Term]
id: GO:0051068
name: dihydrolipoamide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dihydrolipoamide, the reduced form of lipoamide, produced as an intermediate in the reactions in which lipoamide acts as a cofactor." [ISBN:0721601464]
subset: gosubset_prok
synonym: "dihydrolipoamide metabolism" EXACT []
synonym: "dihydrolipoamide reduction" NARROW []
synonym: "dihydrothioctamide metabolic process" EXACT []
synonym: "dihydrothioctamide metabolism" EXACT []
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0043603 ! cellular amide metabolic process
is_a: GO:0051186 ! cofactor metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process

[Term]
id: GO:0051069
name: galactomannan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving galactomannan, a polysaccharide composed of D-galactose and D-mannose. The mannose units form the backbone structure (a linear main chain) with the D-galactose as single side units." [http://www.els.net/els/public/glossary/]
subset: gosubset_prok
synonym: "galactomannan metabolism" EXACT []
is_a: GO:0006080 ! substituted mannan metabolic process

[Term]
id: GO:0051070
name: galactomannan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of galactomannan, a polysaccharide composed of D-galactosyl and D-mannosyl. The mannosyl units form the backbone structure (a linear main chain) with the D-galactosyl as single side units." [GOC:ai]
subset: gosubset_prok
synonym: "galactomannan anabolism" EXACT []
synonym: "galactomannan biosynthesis" EXACT []
synonym: "galactomannan formation" EXACT []
synonym: "galactomannan synthesis" EXACT []
is_a: GO:0000271 ! polysaccharide biosynthetic process
is_a: GO:0051069 ! galactomannan metabolic process

[Term]
id: GO:0051071
name: 4,6-pyruvylated galactose residue metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the pyruvylated galactose residue 4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3-. The galactose residue is part of a larger polysaccharide chain." [GOC:ai, PMID:15173185]
subset: gosubset_prok
synonym: "4,6-pyruvylated galactose residue metabolism" EXACT []
synonym: "4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3 metabolic process" EXACT []
synonym: "4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3 metabolism" EXACT []
synonym: "PvGal metabolic process" EXACT []
synonym: "PvGal metabolism" EXACT []
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0044264 ! cellular polysaccharide metabolic process
is_a: GO:0044723 ! single-organism carbohydrate metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:0051072
name: 4,6-pyruvylated galactose residue biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the pyruvylated galactose residue 4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3-. The galactose residue is part of a larger polysaccharide chain." [GOC:ai, PMID:15173185]
subset: gosubset_prok
synonym: "4,6-pyruvylated galactose residue anabolism" EXACT []
synonym: "4,6-pyruvylated galactose residue biosynthesis" EXACT []
synonym: "4,6-pyruvylated galactose residue formation" EXACT []
synonym: "4,6-pyruvylated galactose residue synthesis" EXACT []
synonym: "4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3 biosynthesis" EXACT []
synonym: "4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3 biosynthetic process" EXACT []
synonym: "PvGal biosynthesis" EXACT []
synonym: "PvGal biosynthetic process" EXACT []
is_a: GO:0033692 ! cellular polysaccharide biosynthetic process
is_a: GO:0051071 ! 4,6-pyruvylated galactose residue metabolic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process

[Term]
id: GO:0051073
name: adenosylcobinamide-GDP ribazoletransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: adenosylcobinamide-GDP + alpha-ribazole = GMP + adenosylcobalamin." [EC:2.7.8.26, MetaCyc:COBALAMINSYN-RXN]
synonym: "adenosylcobinamide-GDP:alpha-ribazole ribazoletransferase activity" EXACT [EC:2.7.8.26]
synonym: "cobalamin (5'-phosphate) synthase activity" EXACT [EC:2.7.8.26]
synonym: "cobalamin synthase activity" EXACT []
synonym: "cobalamin-5'-phosphate synthase activity" EXACT [EC:2.7.8.26]
synonym: "CobS" RELATED [EC:2.7.8.26]
xref: EC:2.7.8.26
xref: MetaCyc:COBALAMINSYN-RXN
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0051074
name: obsolete protein tetramerization activity
namespace: molecular_function
def: "OBSOLETE. The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits." [GOC:ecd]
comment: This term was made obsolete because it represents a process.
synonym: "protein tetramerization activity" EXACT []
is_obsolete: true
replaced_by: GO:0051262

[Term]
id: GO:0051075
name: S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosylmethionine + 7-(aminomethyl)-7-deazaguanosine-tRNA = adenine + methionine + epoxyqueuosine-tRNA. 7-(aminomethyl)-7-deazaguanosine-tRNA is also known as preQ1-tRNA, and epoxyqueuosine-tRNA as oQ-tRNA." [PMID:12731872]
subset: gosubset_prok
synonym: "S-adenosyl methionine:tRNA ribosyltransferase-isomerase activity" EXACT []
is_a: GO:0016740 ! transferase activity
is_a: GO:0016853 ! isomerase activity

[Term]
id: GO:0051077
name: secondary cell septum
namespace: cellular_component
def: "Cell wall structures composed of linear polysaccharides which are deposited at both sides of the primary septum at 90 degrees to the primary septum." [GOC:mtg_sensu, PMID:15194814]
synonym: "secondary septum" BROAD []
is_a: GO:0030428 ! cell septum

[Term]
id: GO:0051078
name: meiotic nuclear envelope disassembly
namespace: biological_process
def: "The cell cycle process in which the controlled breakdown of the nuclear envelope during meiotic cell division occurs." [GOC:bf]
synonym: "meiotic nuclear envelope breakdown" EXACT []
synonym: "meiotic nuclear envelope catabolism" EXACT []
synonym: "meiotic nuclear envelope degradation" EXACT []
is_a: GO:0051081 ! nuclear envelope disassembly
is_a: GO:1903046 ! meiotic cell cycle process
intersection_of: GO:0051081 ! nuclear envelope disassembly
intersection_of: part_of GO:0051321 ! meiotic cell cycle
relationship: part_of GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0051079
name: meiosis I nuclear envelope disassembly
namespace: biological_process
def: "The controlled breakdown of the nuclear envelope during the first division of meiosis." [GOC:bf]
synonym: "meiosis I nuclear envelope breakdown" EXACT []
synonym: "meiosis I nuclear envelope catabolism" EXACT []
synonym: "meiosis I nuclear envelope degradation" EXACT []
is_a: GO:0051078 ! meiotic nuclear envelope disassembly
intersection_of: GO:0051081 ! nuclear envelope disassembly
intersection_of: part_of GO:0007127 ! meiosis I
relationship: part_of GO:0007127 ! meiosis I

[Term]
id: GO:0051080
name: meiosis II nuclear envelope disassembly
namespace: biological_process
def: "The controlled breakdown of the nuclear envelope during the second division of meiosis." [GOC:bf]
synonym: "meiosis II nuclear envelope breakdown" EXACT []
synonym: "meiosis II nuclear envelope catabolism" EXACT []
synonym: "meiosis II nuclear envelope degradation" EXACT []
is_a: GO:0051078 ! meiotic nuclear envelope disassembly
intersection_of: GO:0051081 ! nuclear envelope disassembly
intersection_of: part_of GO:0007135 ! meiosis II
relationship: part_of GO:0007135 ! meiosis II

[Term]
id: GO:0051081
name: nuclear envelope disassembly
namespace: biological_process
def: "The controlled breakdown of the nuclear envelope in the context of a normal process." [GOC:ai]
synonym: "nuclear envelope breakdown" EXACT []
synonym: "nuclear envelope catabolism" EXACT []
synonym: "nuclear envelope degradation" EXACT []
is_a: GO:0006998 ! nuclear envelope organization
is_a: GO:0030397 ! membrane disassembly

[Term]
id: GO:0051082
name: unfolded protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an unfolded protein." [GOC:ai]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_yeast
subset: gosubset_prok
synonym: "binding unfolded ER proteins" NARROW []
synonym: "chaperone activity" RELATED []
synonym: "fimbrium-specific chaperone activity" RELATED []
synonym: "glycoprotein-specific chaperone activity" RELATED []
synonym: "histone-specific chaperone activity" RELATED []
synonym: "ribosomal chaperone activity" RELATED []
synonym: "tubulin-specific chaperone activity" RELATED []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0051083
name: 'de novo' cotranslational protein folding
namespace: biological_process
alt_id: GO:0006444
def: "The process of assisting in the correct noncovalent assembly of the ribosome-bound nascent chains of a multidomain protein whilst other parts of the protein are still being translated." [GOC:rb]
subset: gosubset_prok
synonym: "'de novo' co-translational protein folding" EXACT []
synonym: "multidomain protein assembly" EXACT []
synonym: "nascent polypeptide association" EXACT []
is_a: GO:0006458 ! 'de novo' protein folding

[Term]
id: GO:0051084
name: 'de novo' posttranslational protein folding
namespace: biological_process
def: "The process of assisting in the correct noncovalent folding of newly formed polypeptides or folding intermediates of polypeptides that have exited the ribosome and/or have been stabilized and transferred by other chaperone proteins. This process could involve several cycles of ATP hydrolysis." [GOC:rb]
subset: gosubset_prok
synonym: "'de novo' post-translational protein folding" EXACT []
xref: Reactome:REACT_100416 "Protein folding, Arabidopsis thaliana"
xref: Reactome:REACT_101817 "Protein folding, Sus scrofa"
xref: Reactome:REACT_106260 "Protein folding, Mus musculus"
xref: Reactome:REACT_16952 "Protein folding, Homo sapiens"
xref: Reactome:REACT_28876 "Protein folding, Danio rerio"
xref: Reactome:REACT_28983 "Protein folding, Schizosaccharomyces pombe"
xref: Reactome:REACT_30135 "Protein folding, Saccharomyces cerevisiae"
xref: Reactome:REACT_34382 "Protein folding, Oryza sativa"
xref: Reactome:REACT_77664 "Protein folding, Canis familiaris"
xref: Reactome:REACT_84791 "Protein folding, Xenopus tropicalis"
xref: Reactome:REACT_85464 "Protein folding, Drosophila melanogaster"
xref: Reactome:REACT_88302 "Protein folding, Bos taurus"
xref: Reactome:REACT_89117 "Protein folding, Gallus gallus"
xref: Reactome:REACT_89746 "Protein folding, Taeniopygia guttata"
xref: Reactome:REACT_90293 "Protein folding, Plasmodium falciparum"
xref: Reactome:REACT_90475 "Protein folding, Caenorhabditis elegans"
xref: Reactome:REACT_91665 "Protein folding, Rattus norvegicus"
xref: Reactome:REACT_96282 "Protein folding, Dictyostelium discoideum"
is_a: GO:0006458 ! 'de novo' protein folding

[Term]
id: GO:0051085
name: chaperone mediated protein folding requiring cofactor
namespace: biological_process
def: "The process of assisting in the correct posttranslational noncovalent assembly of proteins, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release." [GOC:rb]
subset: gosubset_prok
synonym: "chaperone co-factor-dependent protein folding" EXACT []
synonym: "chaperone cofactor-dependent 'de novo' protein folding" EXACT [GOC:mah]
synonym: "chaperone cofactor-dependent protein folding" EXACT [GOC:rb]
is_a: GO:0051084 ! 'de novo' posttranslational protein folding
is_a: GO:0061077 ! chaperone-mediated protein folding

[Term]
id: GO:0051086
name: chaperone mediated protein folding independent of cofactor
namespace: biological_process
def: "The process of assisting in the correct noncovalent assembly of posttranslational proteins and does not depend on additional protein cofactors. This function occurs over one or more cycles of nucleotide-dependent binding and release." [GOC:rb]
subset: gosubset_prok
synonym: "chaperone cofactor-independent protein folding" EXACT [GOC:rb]
xref: Reactome:REACT_101718 "Folding of actin by CCT/TriC, Taeniopygia guttata"
xref: Reactome:REACT_103530 "Folding of actin by CCT/TriC, Xenopus tropicalis"
xref: Reactome:REACT_105225 "Folding of actin by CCT/TriC, Canis familiaris"
xref: Reactome:REACT_106967 "Folding of actin by CCT/TriC, Schizosaccharomyces pombe"
xref: Reactome:REACT_16890 "Folding of actin by CCT/TriC, Bos taurus"
xref: Reactome:REACT_17050 "Folding of actin by CCT/TriC, Homo sapiens"
xref: Reactome:REACT_28081 "Folding of actin by CCT/TriC, Gallus gallus"
xref: Reactome:REACT_30363 "Folding of actin by CCT/TriC, Plasmodium falciparum"
xref: Reactome:REACT_30720 "Folding of actin by CCT/TriC, Rattus norvegicus"
xref: Reactome:REACT_84125 "Folding of actin by CCT/TriC, Arabidopsis thaliana"
xref: Reactome:REACT_84283 "Folding of actin by CCT/TriC, Mus musculus"
xref: Reactome:REACT_84927 "Folding of actin by CCT/TriC, Dictyostelium discoideum"
xref: Reactome:REACT_86026 "Folding of actin by CCT/TriC, Drosophila melanogaster"
xref: Reactome:REACT_88264 "Folding of actin by CCT/TriC, Caenorhabditis elegans"
xref: Reactome:REACT_90976 "Folding of actin by CCT/TriC, Sus scrofa"
xref: Reactome:REACT_91038 "Folding of actin by CCT/TriC, Saccharomyces cerevisiae"
xref: Reactome:REACT_93546 "Folding of actin by CCT/TriC, Bos taurus"
xref: Reactome:REACT_95493 "Folding of actin by CCT/TriC, Oryza sativa"
xref: Reactome:REACT_97856 "Folding of actin by CCT/TriC, Danio rerio"
is_a: GO:0051084 ! 'de novo' posttranslational protein folding
is_a: GO:0061077 ! chaperone-mediated protein folding

[Term]
id: GO:0051087
name: chaperone binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [http://www.onelook.com]
subset: gosubset_prok
synonym: "chaperone protein binding" EXACT []
synonym: "co-chaperone activity" RELATED []
synonym: "co-chaperonin activity" RELATED []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0051088
name: PMA-inducible membrane protein ectodomain proteolysis
namespace: biological_process
def: "The proteolytic cleavage of transmembrane proteins and release of their ectodomain that occurs after induction by phorbol-12-myristate-13-acetate (PMA), a protein kinase C agonist." [PMID:12714508]
is_a: GO:0006509 ! membrane protein ectodomain proteolysis

[Term]
id: GO:0051089
name: constitutive protein ectodomain proteolysis
namespace: biological_process
def: "The proteolytic cleavage of transmembrane proteins and release of their ectodomain that occurs constantly, regardless of environmental conditions or demands." [PMID:12714508]
subset: gosubset_prok
is_a: GO:0006509 ! membrane protein ectodomain proteolysis

[Term]
id: GO:0051090
name: regulation of sequence-specific DNA binding transcription factor activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:ai]
subset: gosubset_prok
synonym: "regulation of transcription factor activity" BROAD [GOC:dph, GOC:tb]
xref: Reactome:REACT_104536 "Activation of the AP-1 family of transcription factors, Bos taurus"
xref: Reactome:REACT_107559 "Activation of the AP-1 family of transcription factors, Danio rerio"
xref: Reactome:REACT_109535 "Activation of the AP-1 family of transcription factors, Schizosaccharomyces pombe"
xref: Reactome:REACT_110257 "Activation of the AP-1 family of transcription factors, Drosophila melanogaster"
xref: Reactome:REACT_110693 "Activation of the AP-1 family of transcription factors, Gallus gallus"
xref: Reactome:REACT_21326 "Activation of the AP-1 family of transcription factors, Homo sapiens"
xref: Reactome:REACT_82719 "Activation of the AP-1 family of transcription factors, Xenopus tropicalis"
xref: Reactome:REACT_83365 "Activation of the AP-1 family of transcription factors, Sus scrofa"
xref: Reactome:REACT_90659 "Activation of the AP-1 family of transcription factors, Taeniopygia guttata"
xref: Reactome:REACT_92725 "Activation of the AP-1 family of transcription factors, Canis familiaris"
xref: Reactome:REACT_96476 "Activation of the AP-1 family of transcription factors, Rattus norvegicus"
xref: Reactome:REACT_99415 "Activation of the AP-1 family of transcription factors, Mus musculus"
is_a: GO:0006355 ! regulation of transcription, DNA-templated
is_a: GO:0065009 ! regulation of molecular function
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003700 ! transcription factor activity, sequence-specific DNA binding
relationship: regulates GO:0003700 ! transcription factor activity, sequence-specific DNA binding

[Term]
id: GO:0051091
name: positive regulation of sequence-specific DNA binding transcription factor activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:ai]
subset: gosubset_prok
synonym: "activation of transcription factor activity" NARROW []
synonym: "positive regulation of transcription factor activity" BROAD [GOC:dph, GOC:tb]
synonym: "stimulation of transcription factor activity" NARROW []
synonym: "up regulation of transcription factor activity" EXACT []
synonym: "up-regulation of transcription factor activity" EXACT []
synonym: "upregulation of transcription factor activity" EXACT []
is_a: GO:0044093 ! positive regulation of molecular function
is_a: GO:0045893 ! positive regulation of transcription, DNA-templated
is_a: GO:0051090 ! regulation of sequence-specific DNA binding transcription factor activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003700 ! transcription factor activity, sequence-specific DNA binding
relationship: positively_regulates GO:0003700 ! transcription factor activity, sequence-specific DNA binding

[Term]
id: GO:0051092
name: positive regulation of NF-kappaB transcription factor activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB." [GOC:dph, GOC:tb, PMID:15087454, PMID:15170030]
synonym: "activation of NF-kappaB" EXACT []
synonym: "activation of NF-kappaB transcription factor" EXACT [GOC:dph, GOC:tb]
synonym: "NF-kappaB activation" EXACT []
xref: Reactome:REACT_107873 "TAK1 activates NFkB by phosphorylation and activation of IKKs complex, Rattus norvegicus"
xref: Reactome:REACT_113398 "TAK1 activates NFkB by phosphorylation and activation of IKKs complex, Taeniopygia guttata"
xref: Reactome:REACT_113766 "TAK1 activates NFkB by phosphorylation and activation of IKKs complex, Drosophila melanogaster"
xref: Reactome:REACT_21281 "TAK1 activates NFkB by phosphorylation and activation of IKKs complex, Homo sapiens"
xref: Reactome:REACT_31084 "TAK1 activates NFkB by phosphorylation and activation of IKKs complex, Canis familiaris"
xref: Reactome:REACT_33907 "TAK1 activates NFkB by phosphorylation and activation of IKKs complex, Danio rerio"
xref: Reactome:REACT_34168 "TAK1 activates NFkB by phosphorylation and activation of IKKs complex, Sus scrofa"
xref: Reactome:REACT_34256 "TAK1 activates NFkB by phosphorylation and activation of IKKs complex, Bos taurus"
xref: Reactome:REACT_87914 "TAK1 activates NFkB by phosphorylation and activation of IKKs complex, Xenopus tropicalis"
xref: Reactome:REACT_95400 "TAK1 activates NFkB by phosphorylation and activation of IKKs complex, Mus musculus"
is_a: GO:0051091 ! positive regulation of sequence-specific DNA binding transcription factor activity

[Term]
id: GO:0051093
name: negative regulation of developmental process
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of developmental process" EXACT []
synonym: "down-regulation of developmental process" EXACT []
synonym: "downregulation of developmental process" EXACT []
synonym: "inhibition of developmental process" NARROW []
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032502 ! developmental process
relationship: negatively_regulates GO:0032502 ! developmental process

[Term]
id: GO:0051094
name: positive regulation of developmental process
namespace: biological_process
def: "Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai]
subset: gosubset_prok
synonym: "activation of developmental process" NARROW []
synonym: "stimulation of developmental process" NARROW []
synonym: "up regulation of developmental process" EXACT []
synonym: "up-regulation of developmental process" EXACT []
synonym: "upregulation of developmental process" EXACT []
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032502 ! developmental process
relationship: positively_regulates GO:0032502 ! developmental process

[Term]
id: GO:0051095
name: regulation of helicase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of helicase activity." [GOC:ai]
subset: gosubset_prok
is_a: GO:0051336 ! regulation of hydrolase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004386 ! helicase activity
relationship: regulates GO:0004386 ! helicase activity

[Term]
id: GO:0051096
name: positive regulation of helicase activity
namespace: biological_process
def: "Any process that activates or increases the activity of a helicase." [GOC:ai]
subset: gosubset_prok
synonym: "activation of helicase activity" NARROW []
synonym: "stimulation of helicase activity" NARROW []
synonym: "up regulation of helicase activity" EXACT []
synonym: "up-regulation of helicase activity" EXACT []
synonym: "upregulation of helicase activity" EXACT []
is_a: GO:0051095 ! regulation of helicase activity
is_a: GO:0051345 ! positive regulation of hydrolase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004386 ! helicase activity
relationship: positively_regulates GO:0004386 ! helicase activity

[Term]
id: GO:0051097
name: negative regulation of helicase activity
namespace: biological_process
def: "Any process that stops or reduces the activity of a helicase." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of helicase activity" EXACT []
synonym: "down-regulation of helicase activity" EXACT []
synonym: "downregulation of helicase activity" EXACT []
synonym: "inhibition of helicase activity" NARROW []
is_a: GO:0051095 ! regulation of helicase activity
is_a: GO:0051346 ! negative regulation of hydrolase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004386 ! helicase activity
relationship: negatively_regulates GO:0004386 ! helicase activity

[Term]
id: GO:0051098
name: regulation of binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule." [GOC:ai]
subset: gosubset_prok
is_a: GO:0065009 ! regulation of molecular function
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0005488 ! binding
relationship: regulates GO:0005488 ! binding

[Term]
id: GO:0051099
name: positive regulation of binding
namespace: biological_process
def: "Any process that activates or increases the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule." [GOC:ai]
subset: gosubset_prok
synonym: "activation of binding" NARROW []
synonym: "stimulation of binding" NARROW []
synonym: "up regulation of binding" EXACT []
synonym: "up-regulation of binding" EXACT []
synonym: "upregulation of binding" EXACT []
is_a: GO:0044093 ! positive regulation of molecular function
is_a: GO:0051098 ! regulation of binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0005488 ! binding
relationship: positively_regulates GO:0005488 ! binding

[Term]
id: GO:0051100
name: negative regulation of binding
namespace: biological_process
def: "Any process that stops or reduces the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of binding" EXACT []
synonym: "down-regulation of binding" EXACT []
synonym: "downregulation of binding" EXACT []
synonym: "inhibition of binding" NARROW []
is_a: GO:0044092 ! negative regulation of molecular function
is_a: GO:0051098 ! regulation of binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0005488 ! binding
relationship: negatively_regulates GO:0005488 ! binding

[Term]
id: GO:0051101
name: regulation of DNA binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:ai, GOC:dph, GOC:tb]
subset: gosubset_prok
is_a: GO:0051098 ! regulation of binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003677 ! DNA binding
relationship: regulates GO:0003677 ! DNA binding

[Term]
id: GO:0051102
name: DNA ligation involved in DNA recombination
namespace: biological_process
def: "The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, that contributes to DNA recombination." [GOC:ai]
subset: gosubset_prok
synonym: "DNA ligation during DNA recombination" RELATED [GOC:dph, GOC:tb]
is_a: GO:0006266 ! DNA ligation
intersection_of: GO:0006266 ! DNA ligation
intersection_of: part_of GO:0006310 ! DNA recombination
relationship: part_of GO:0006310 ! DNA recombination

[Term]
id: GO:0051103
name: DNA ligation involved in DNA repair
namespace: biological_process
def: "The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, that contributes to DNA repair." [GOC:ai]
subset: gosubset_prok
synonym: "DNA ligation during DNA repair" RELATED [GOC:dph, GOC:tb]
is_a: GO:0006266 ! DNA ligation
intersection_of: GO:0006266 ! DNA ligation
intersection_of: part_of GO:0006281 ! DNA repair
relationship: part_of GO:0006281 ! DNA repair

[Term]
id: GO:0051104
name: DNA-dependent DNA replication DNA ligation
namespace: biological_process
def: "The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, that contributes to DNA-dependent DNA replication." [GOC:ai, GOC:dph, GOC:tb]
subset: gosubset_prok
synonym: "DNA ligation during DNA-dependent DNA replication" RELATED [GOC:dph, GOC:tb]
synonym: "DNA ligation involved in DNA-dependent DNA replication" EXACT []
is_a: GO:0006266 ! DNA ligation
intersection_of: GO:0006266 ! DNA ligation
intersection_of: part_of GO:0006261 ! DNA-dependent DNA replication
relationship: part_of GO:0006261 ! DNA-dependent DNA replication

[Term]
id: GO:0051105
name: regulation of DNA ligation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA ligation, the re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase." [GOC:ai]
subset: gosubset_prok
is_a: GO:0051052 ! regulation of DNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006266 ! DNA ligation
relationship: regulates GO:0006266 ! DNA ligation

[Term]
id: GO:0051106
name: positive regulation of DNA ligation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA ligation, the re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase." [GOC:ai]
subset: gosubset_prok
synonym: "activation of DNA ligation" NARROW []
synonym: "stimulation of DNA ligation" NARROW []
synonym: "up regulation of DNA ligation" EXACT []
synonym: "up-regulation of DNA ligation" EXACT []
synonym: "upregulation of DNA ligation" EXACT []
is_a: GO:0051054 ! positive regulation of DNA metabolic process
is_a: GO:0051105 ! regulation of DNA ligation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006266 ! DNA ligation
relationship: positively_regulates GO:0006266 ! DNA ligation

[Term]
id: GO:0051107
name: negative regulation of DNA ligation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA ligation, the re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of DNA ligation" EXACT []
synonym: "down-regulation of DNA ligation" EXACT []
synonym: "downregulation of DNA ligation" EXACT []
synonym: "inhibition of DNA ligation" NARROW []
is_a: GO:0051053 ! negative regulation of DNA metabolic process
is_a: GO:0051105 ! regulation of DNA ligation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006266 ! DNA ligation
relationship: negatively_regulates GO:0006266 ! DNA ligation

[Term]
id: GO:0051108
name: carnitine-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-carnitine + CoA + ATP = AMP + diphosphate + D-carnitinyl-CoA." [MetaCyc:DCARNCOALIG-RXN]
synonym: "carnitine synthetase activity" EXACT []
synonym: "crotonobetaine/carnitine-CoA ligase activity" BROAD []
xref: MetaCyc:DCARNCOALIG-RXN
xref: RHEA:30546
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0051109
name: crotonobetaine-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: CoA + crotono-betaine + ATP = AMP + diphosphate + crotonobetainyl-CoA." [MetaCyc:CROTCOALIG-RXN]
synonym: "crotonobetaine-CoA synthase activity" EXACT []
synonym: "crotonobetaine/carnitine-CoA ligase activity" BROAD []
xref: MetaCyc:CROTCOALIG-RXN
xref: RHEA:30082
is_a: GO:0016405 ! CoA-ligase activity

[Term]
id: GO:0051110
name: peptidyl-histidine uridylylation, to form peptidyl-1'-(phospho-5'-uridine)-L-histidine
namespace: biological_process
def: "The uridylylation of peptidyl-histidine to form peptidyl-1'-(phospho-5'-uridine)-L-histidine (otherwise known as tau-UMP-histidine, tele-UMP-histidine)." [RESID:AA0372]
subset: gosubset_prok
xref: RESID:AA0372
is_a: GO:0051114 ! peptidyl-histidine uridylylation

[Term]
id: GO:0051111
name: peptidyl-histidine adenylylation
namespace: biological_process
def: "The adenylylation of peptidyl-histidine to form peptidyl-1'-(phospho-5'-adenosine)-L-histidine (otherwise known as tau-AMP-histidine, tele-AMP-histidine) or peptidyl-3'-(phospho-5'-adenosine)-L-histidine (otherwise known as pi-AMP-histidine, pros-AMP-histidine)." [RESID:AA0371]
subset: gosubset_prok
xref: RESID:AA0371
is_a: GO:0018117 ! protein adenylylation
is_a: GO:0018202 ! peptidyl-histidine modification

[Term]
id: GO:0051112
name: peptidyl-histidine adenylylation, to form peptidyl-1'-(phospho-5'-adenosine)-L-histidine
namespace: biological_process
def: "The adenylylation of peptidyl-histidine to form peptidyl-1'-(phospho-5'-adenosine)-L-histidine (otherwise known as tau-AMP-histidine, tele-AMP-histidine)." [RESID:AA0371]
subset: gosubset_prok
xref: RESID:AA0371
is_a: GO:0051111 ! peptidyl-histidine adenylylation

[Term]
id: GO:0051113
name: enzyme active site formation via 1'-(phospho-5'-adenosine)-L-histidine
namespace: biological_process
def: "The transient adenylylation of peptidyl-histidine to form 1'-(phospho-5'-adenosine)-L-histidine (otherwise known as tau-AMP-histidine, tele-AMP-histidine)." [RESID:AA0371]
subset: gosubset_prok
xref: RESID:AA0371
is_a: GO:0018307 ! enzyme active site formation
is_a: GO:0051112 ! peptidyl-histidine adenylylation, to form peptidyl-1'-(phospho-5'-adenosine)-L-histidine

[Term]
id: GO:0051114
name: peptidyl-histidine uridylylation
namespace: biological_process
def: "The uridylylation of peptidyl-histidine to form peptidyl-1'-(phospho-5'-uridine)-L-histidine (otherwise known as tau-UMP-histidine, tele-UMP-histidine) or peptidyl-3'-(phospho-5'-uridine)-L-histidine (otherwise known as pi-UMP-histidine, pros-UMP-histidine)." [RESID:AA0372]
subset: gosubset_prok
xref: RESID:AA0372
is_a: GO:0018177 ! protein uridylylation
is_a: GO:0018202 ! peptidyl-histidine modification

[Term]
id: GO:0051115
name: enzyme active site formation via 1'-(phospho-5'-uridine)-L-histidine
namespace: biological_process
def: "The transient uridylylation of peptidyl-histidine to form 1'-(phospho-5'-uridine)-L-histidine (otherwise known as tau-UMP-histidine, tele-UMP-histidine)." [RESID:AA0372]
subset: gosubset_prok
xref: RESID:AA0372
is_a: GO:0018307 ! enzyme active site formation
is_a: GO:0051110 ! peptidyl-histidine uridylylation, to form peptidyl-1'-(phospho-5'-uridine)-L-histidine

[Term]
id: GO:0051116
name: cobaltochelatase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + Co(2+) + H(2)O + hydrogenobyrinate a,c-diamide = ADP + cob(II)yrinate a,c diamide + 4 H(+) + phosphate." [EC:6.6.1.2, RHEA:15344]
subset: gosubset_prok
synonym: "CobN-CobST" RELATED [EC:6.6.1.2]
synonym: "CobNST" NARROW []
synonym: "hydrogenobyrinic acid a,c-diamide cobaltochelatase activity" EXACT []
synonym: "hydrogenobyrinic-acid-a,c-diamide:cobalt cobalt-ligase (ADP-forming)" EXACT [EC:6.6.1.2]
xref: EC:6.6.1.2
xref: KEGG:R05227
xref: MetaCyc:R342-RXN
xref: RHEA:15344
is_a: GO:0051003 ! ligase activity, forming nitrogen-metal bonds, forming coordination complexes

[Term]
id: GO:0051117
name: ATPase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an ATPase, any enzyme that catalyzes the hydrolysis of ATP." [GOC:ai]
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0051118
name: glucan endo-1,3-alpha-glucosidase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of (1->3)-alpha-D-glucosidic linkages in isolichenin, pseudonigeran and nigeran." [EC:3.2.1.59]
synonym: "1,3(1,3;1,4)-alpha-D-glucan 3-glucanohydrolase activity" EXACT [EC:3.2.1.59]
synonym: "cariogenanase activity" EXACT [EC:3.2.1.59]
synonym: "cariogenase activity" EXACT [EC:3.2.1.59]
synonym: "endo-(1->3)-alpha-glucanase activity" EXACT [EC:3.2.1.59]
synonym: "endo-1,3-alpha-D-glucanase activity" EXACT [EC:3.2.1.59]
synonym: "endo-1,3-alpha-glucanase activity" EXACT [EC:3.2.1.59]
synonym: "mutanase activity" EXACT [EC:3.2.1.59]
xref: EC:3.2.1.59
xref: MetaCyc:3.2.1.59-RXN
is_a: GO:0015926 ! glucosidase activity

[Term]
id: GO:0051119
name: sugar transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a sugar from one side of the membrane to the other. A sugar is any member of a class of sweet, water-soluble, crystallizable carbohydrates, which are the monosaccharides and smaller oligosaccharides." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "sugar/polyol channel activity" NARROW []
xref: Reactome:REACT_112187 "GLUT7 and GLUT11 transport glucose and fructose, Plasmodium falciparum"
xref: Reactome:REACT_113009 "GLUT7 and GLUT11 transport glucose and fructose, Dictyostelium discoideum"
xref: Reactome:REACT_113132 "GLUT7 and GLUT11 transport glucose and fructose, Oryza sativa"
xref: Reactome:REACT_113932 "GLUT7 and GLUT11 transport glucose and fructose, Mycobacterium tuberculosis"
xref: Reactome:REACT_113992 "GLUT7 and GLUT11 transport glucose and fructose, Arabidopsis thaliana"
xref: Reactome:REACT_19138 "GLUT7 and GLUT11 transport glucose and fructose, Homo sapiens"
xref: Reactome:REACT_28280 "GLUT7 and GLUT11 transport glucose and fructose, Sus scrofa"
xref: Reactome:REACT_32625 "GLUT7 and GLUT11 transport glucose and fructose, Bos taurus"
xref: Reactome:REACT_81989 "GLUT7 and GLUT11 transport glucose and fructose, Xenopus tropicalis"
xref: Reactome:REACT_83614 "GLUT7 and GLUT11 transport glucose and fructose, Danio rerio"
xref: Reactome:REACT_84634 "GLUT7 and GLUT11 transport glucose and fructose, Taeniopygia guttata"
xref: Reactome:REACT_87921 "GLUT7 and GLUT11 transport glucose and fructose, Gallus gallus"
xref: Reactome:REACT_93286 "GLUT7 and GLUT11 transport glucose and fructose, Canis familiaris"
xref: Reactome:REACT_96496 "GLUT7 and GLUT11 transport glucose and fructose, Rattus norvegicus"
xref: Reactome:REACT_97145 "GLUT7 and GLUT11 transport glucose and fructose, Mus musculus"
is_a: GO:0015144 ! carbohydrate transmembrane transporter activity

[Term]
id: GO:0051120
name: hepoxilin A3 synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid = (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate. 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid is also known as 12S-HpETE, and (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate as hepoxilin A3." [PMID:15123652]
is_a: GO:0016853 ! isomerase activity

[Term]
id: GO:0051121
name: hepoxilin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving hepoxilins, a class of bioactive icosanoids with roles in the regulation of cell physiology." [PMID:15123652]
subset: gosubset_prok
synonym: "hepoxilin metabolism" EXACT []
is_a: GO:0001676 ! long-chain fatty acid metabolic process
is_a: GO:0033559 ! unsaturated fatty acid metabolic process

[Term]
id: GO:0051122
name: hepoxilin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of hepoxilins, a class of bioactive icosanoids with roles in the regulation of cell physiology." [GOC:ai]
subset: gosubset_prok
synonym: "hepoxilin anabolism" EXACT []
synonym: "hepoxilin biosynthesis" EXACT []
synonym: "hepoxilin formation" EXACT []
synonym: "hepoxilin synthesis" EXACT []
is_a: GO:0006636 ! unsaturated fatty acid biosynthetic process
is_a: GO:0042759 ! long-chain fatty acid biosynthetic process
is_a: GO:0051121 ! hepoxilin metabolic process

[Term]
id: GO:0051123
name: RNA polymerase II transcriptional preinitiation complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase." [GOC:txnOH, PMID:10882737, PMID:15020047]
synonym: "RNA polymerase II transcription PIC biosynthesis" EXACT []
synonym: "RNA polymerase II transcription PIC formation" EXACT []
synonym: "RNA polymerase II transcriptional preinitiation complex formation" EXACT []
is_a: GO:0070897 ! DNA-templated transcriptional preinitiation complex assembly
relationship: part_of GO:0006367 ! transcription initiation from RNA polymerase II promoter

[Term]
id: GO:0051124
name: synaptic growth at neuromuscular junction
namespace: biological_process
def: "The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates." [ISBN:0721662544]
synonym: "cholinergic synaptogenesis" RELATED []
is_a: GO:0007416 ! synapse assembly
is_a: GO:0007528 ! neuromuscular junction development
is_a: GO:0048589 ! developmental growth

[Term]
id: GO:0051125
name: regulation of actin nucleation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament." [GOC:ai]
is_a: GO:0030833 ! regulation of actin filament polymerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045010 ! actin nucleation
relationship: regulates GO:0045010 ! actin nucleation

[Term]
id: GO:0051126
name: negative regulation of actin nucleation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament." [GOC:ai]
synonym: "down regulation of actin nucleation" EXACT []
synonym: "down-regulation of actin nucleation" EXACT []
synonym: "downregulation of actin nucleation" EXACT []
synonym: "inhibition of actin nucleation" NARROW []
is_a: GO:0051125 ! regulation of actin nucleation
is_a: GO:0051494 ! negative regulation of cytoskeleton organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045010 ! actin nucleation
relationship: negatively_regulates GO:0045010 ! actin nucleation

[Term]
id: GO:0051127
name: positive regulation of actin nucleation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament." [GOC:ai]
synonym: "activation of actin nucleation" NARROW []
synonym: "stimulation of actin nucleation" NARROW []
synonym: "up regulation of actin nucleation" EXACT []
synonym: "up-regulation of actin nucleation" EXACT []
synonym: "upregulation of actin nucleation" EXACT []
is_a: GO:0051125 ! regulation of actin nucleation
is_a: GO:0051495 ! positive regulation of cytoskeleton organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045010 ! actin nucleation
relationship: positively_regulates GO:0045010 ! actin nucleation

[Term]
id: GO:0051128
name: regulation of cellular component organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]
subset: gosubset_prok
synonym: "regulation of cell organisation" RELATED [GOC:mah]
synonym: "regulation of cell organization" RELATED [GOC:mah]
synonym: "regulation of cellular component organisation" EXACT [GOC:curators]
synonym: "regulation of cellular component organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016043 ! cellular component organization
relationship: regulates GO:0016043 ! cellular component organization

[Term]
id: GO:0051129
name: negative regulation of cellular component organization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of cell organization" EXACT []
synonym: "down-regulation of cell organization" EXACT []
synonym: "downregulation of cell organization" EXACT []
synonym: "inhibition of cell organization" NARROW []
synonym: "negative regulation of cell organisation" RELATED [GOC:mah]
synonym: "negative regulation of cellular component organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016043 ! cellular component organization
relationship: negatively_regulates GO:0016043 ! cellular component organization

[Term]
id: GO:0051130
name: positive regulation of cellular component organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]
synonym: "activation of cell organization" NARROW []
synonym: "positive regulation of cell organisation" EXACT []
synonym: "positive regulation of cellular component organization and biogenesis" RELATED [GOC:mah]
synonym: "stimulation of cell organization" NARROW []
synonym: "up regulation of cell organization" EXACT []
synonym: "up-regulation of cell organization" EXACT []
synonym: "upregulation of cell organization" EXACT []
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016043 ! cellular component organization
relationship: positively_regulates GO:0016043 ! cellular component organization

[Term]
id: GO:0051131
name: chaperone-mediated protein complex assembly
namespace: biological_process
alt_id: GO:0034619
def: "The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex." [GOC:ai]
subset: gosubset_prok
synonym: "cellular chaperone-mediated protein complex assembly" EXACT []
synonym: "chaperone activity" RELATED []
synonym: "protein complex assembly, multichaperone pathway" EXACT []
is_a: GO:0043623 ! cellular protein complex assembly

[Term]
id: GO:0051132
name: NK T cell activation
namespace: biological_process
def: "The change in morphology and behavior of a mature or immature natural killer T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [ISBN:0781735149, PMID:12154375, PMID:9133426]
comment: Note that NK T cells are a distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repetoire of variable region gene segments.
synonym: "natural killer T cell activation" EXACT []
synonym: "natural T cell activation" EXACT []
synonym: "NK T lymphocyte activation" EXACT []
synonym: "NK T-cell activation" EXACT []
synonym: "NK T-lymphocyte activation" EXACT []
synonym: "NKT cell activation" EXACT []
synonym: "NT cell activation" EXACT []
is_a: GO:0046631 ! alpha-beta T cell activation

[Term]
id: GO:0051133
name: regulation of NK T cell activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of natural killer T cell activation." [ISBN:0781735149, PMID:12154375, PMID:9133426]
synonym: "regulation of natural killer T cell activation" EXACT []
synonym: "regulation of natural T cell activation" EXACT []
synonym: "regulation of NK T lymphocyte activation" EXACT []
synonym: "regulation of NK T-cell activation" EXACT []
synonym: "regulation of NK T-lymphocyte activation" EXACT []
synonym: "regulation of NKT cell activation" EXACT []
synonym: "regulation of NT cell activation" EXACT []
is_a: GO:0046634 ! regulation of alpha-beta T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051132 ! NK T cell activation
relationship: regulates GO:0051132 ! NK T cell activation

[Term]
id: GO:0051134
name: negative regulation of NK T cell activation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer T cell activation." [ISBN:0781735149, PMID:12154375, PMID:9133426]
synonym: "down regulation of NK T cell activation" EXACT []
synonym: "down-regulation of NK T cell activation" EXACT []
synonym: "downregulation of NK T cell activation" EXACT []
synonym: "inhibition of NK T cell activation" NARROW []
synonym: "negative regulation of natural killer T cell activation" EXACT []
synonym: "negative regulation of natural T cell activation" EXACT []
synonym: "negative regulation of NK T lymphocyte activation" EXACT []
synonym: "negative regulation of NK T-cell activation" EXACT []
synonym: "negative regulation of NK T-lymphocyte activation" EXACT []
synonym: "negative regulation of NKT cell activation" EXACT []
synonym: "negative regulation of NT cell activation" EXACT []
is_a: GO:0046636 ! negative regulation of alpha-beta T cell activation
is_a: GO:0051133 ! regulation of NK T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051132 ! NK T cell activation
relationship: negatively_regulates GO:0051132 ! NK T cell activation

[Term]
id: GO:0051135
name: positive regulation of NK T cell activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of natural killer T cell activation." [ISBN:0781735149, PMID:12154375, PMID:9133426]
synonym: "activation of NK T cell activation" NARROW []
synonym: "positive regulation of natural killer T cell activation" EXACT []
synonym: "positive regulation of natural T cell activation" EXACT []
synonym: "positive regulation of NK T lymphocyte activation" EXACT []
synonym: "positive regulation of NK T-cell activation" EXACT []
synonym: "positive regulation of NK T-lymphocyte activation" EXACT []
synonym: "positive regulation of NKT cell activation" EXACT []
synonym: "positive regulation of NT cell activation" EXACT []
synonym: "stimulation of NK T cell activation" NARROW []
synonym: "up regulation of NK T cell activation" EXACT []
synonym: "up-regulation of NK T cell activation" EXACT []
synonym: "upregulation of NK T cell activation" EXACT []
is_a: GO:0046635 ! positive regulation of alpha-beta T cell activation
is_a: GO:0051133 ! regulation of NK T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051132 ! NK T cell activation
relationship: positively_regulates GO:0051132 ! NK T cell activation

[Term]
id: GO:0051136
name: regulation of NK T cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of natural killer T cell differentiation." [ISBN:0781735149, PMID:12154375, PMID:9133426]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "regulation of natural killer T cell differentiation" EXACT []
synonym: "regulation of natural T cell differentiation" EXACT []
synonym: "regulation of NK T cell development" RELATED [GOC:add]
synonym: "regulation of NK T lymphocyte differentiation" EXACT []
synonym: "regulation of NK T-cell differentiation" EXACT []
synonym: "regulation of NK T-lymphocyte differentiation" EXACT []
synonym: "regulation of NKT cell differentiation" EXACT []
synonym: "regulation of NT cell differentiation" EXACT []
is_a: GO:0046637 ! regulation of alpha-beta T cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001865 ! NK T cell differentiation
relationship: regulates GO:0001865 ! NK T cell differentiation

[Term]
id: GO:0051137
name: negative regulation of NK T cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer T cell differentiation." [ISBN:0781735149, PMID:12154375, PMID:9133426]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "down regulation of NK T cell differentiation" EXACT []
synonym: "down-regulation of NK T cell differentiation" EXACT []
synonym: "downregulation of NK T cell differentiation" EXACT []
synonym: "inhibition of NK T cell differentiation" NARROW []
synonym: "negative regulation of natural killer T cell differentiation" EXACT []
synonym: "negative regulation of natural T cell differentiation" EXACT []
synonym: "negative regulation of NK T cell development" RELATED [GOC:add]
synonym: "negative regulation of NK T lymphocyte differentiation" EXACT []
synonym: "negative regulation of NK T-cell differentiation" EXACT []
synonym: "negative regulation of NK T-lymphocyte differentiation" EXACT []
synonym: "negative regulation of NKT cell differentiation" EXACT []
synonym: "negative regulation of NT cell differentiation" EXACT []
is_a: GO:0046639 ! negative regulation of alpha-beta T cell differentiation
is_a: GO:0051136 ! regulation of NK T cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001865 ! NK T cell differentiation
relationship: negatively_regulates GO:0001865 ! NK T cell differentiation

[Term]
id: GO:0051138
name: positive regulation of NK T cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of natural killer T cell differentiation." [ISBN:0781735149, PMID:12154375, PMID:9133426]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "activation of NK T cell differentiation" NARROW []
synonym: "positive regulation of natural killer T cell differentiation" EXACT []
synonym: "positive regulation of natural T cell differentiation" EXACT []
synonym: "positive regulation of NK T cell development" RELATED [GOC:add]
synonym: "positive regulation of NK T lymphocyte differentiation" EXACT []
synonym: "positive regulation of NK T-cell differentiation" EXACT []
synonym: "positive regulation of NK T-lymphocyte differentiation" EXACT []
synonym: "positive regulation of NKT cell differentiation" EXACT []
synonym: "positive regulation of NT cell differentiation" EXACT []
synonym: "stimulation of NK T cell differentiation" NARROW []
synonym: "up regulation of NK T cell differentiation" EXACT []
synonym: "up-regulation of NK T cell differentiation" EXACT []
synonym: "upregulation of NK T cell differentiation" EXACT []
is_a: GO:0046638 ! positive regulation of alpha-beta T cell differentiation
is_a: GO:0051136 ! regulation of NK T cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001865 ! NK T cell differentiation
relationship: positively_regulates GO:0001865 ! NK T cell differentiation

[Term]
id: GO:0051139
name: metal ion:proton antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: metal ion(in) + H+(out) = metal ion(out) + H+(in)." [GOC:mlg]
subset: gosubset_prok
synonym: "metal ion:hydrogen antiporter activity" EXACT []
xref: Reactome:REACT_112591 "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages, Staphylococcus aureus N315"
xref: Reactome:REACT_20522 "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages, Homo sapiens"
xref: Reactome:REACT_28197 "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages, Taeniopygia guttata"
xref: Reactome:REACT_32699 "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages, Oryza sativa"
xref: Reactome:REACT_33441 "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages, Mus musculus"
xref: Reactome:REACT_77716 "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages, Plasmodium falciparum"
xref: Reactome:REACT_78795 "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages, Rattus norvegicus"
xref: Reactome:REACT_80602 "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages, Caenorhabditis elegans"
xref: Reactome:REACT_81351 "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages, Drosophila melanogaster"
xref: Reactome:REACT_84689 "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages, Dictyostelium discoideum"
xref: Reactome:REACT_86097 "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages, Sus scrofa"
xref: Reactome:REACT_88038 "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages, Arabidopsis thaliana"
xref: Reactome:REACT_90440 "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages, Xenopus tropicalis"
xref: Reactome:REACT_92067 "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages, Bos taurus"
xref: Reactome:REACT_92165 "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages, Gallus gallus"
xref: Reactome:REACT_95330 "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages, Canis familiaris"
is_a: GO:0015299 ! solute:proton antiporter activity
is_a: GO:0015491 ! cation:cation antiporter activity
is_a: GO:0046873 ! metal ion transmembrane transporter activity

[Term]
id: GO:0051140
name: regulation of NK T cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of natural killer T cell proliferation." [ISBN:0781735149, PMID:12154375, PMID:9133426]
synonym: "regulation of natural killer T cell proliferation" EXACT []
synonym: "regulation of natural T cell proliferation" EXACT []
synonym: "regulation of NK T lymphocyte proliferation" EXACT []
synonym: "regulation of NK T-cell proliferation" EXACT []
synonym: "regulation of NK T-lymphocyte proliferation" EXACT []
synonym: "regulation of NKT cell proliferation" EXACT []
synonym: "regulation of NT cell proliferation" EXACT []
is_a: GO:0046640 ! regulation of alpha-beta T cell proliferation
is_a: GO:0051133 ! regulation of NK T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001866 ! NK T cell proliferation
relationship: regulates GO:0001866 ! NK T cell proliferation

[Term]
id: GO:0051141
name: negative regulation of NK T cell proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer T cell proliferation." [ISBN:0781735149, PMID:12154375, PMID:9133426]
synonym: "down regulation of NK T cell proliferation" EXACT []
synonym: "down-regulation of NK T cell proliferation" EXACT []
synonym: "downregulation of NK T cell proliferation" EXACT []
synonym: "inhibition of NK T cell proliferation" NARROW []
synonym: "negative regulation of natural killer T cell proliferation" EXACT []
synonym: "negative regulation of natural T cell proliferation" EXACT []
synonym: "negative regulation of NK T lymphocyte proliferation" EXACT []
synonym: "negative regulation of NK T-cell proliferation" EXACT []
synonym: "negative regulation of NK T-lymphocyte proliferation" EXACT []
synonym: "negative regulation of NKT cell proliferation" EXACT []
synonym: "negative regulation of NT cell proliferation" EXACT []
is_a: GO:0046642 ! negative regulation of alpha-beta T cell proliferation
is_a: GO:0051134 ! negative regulation of NK T cell activation
is_a: GO:0051140 ! regulation of NK T cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001866 ! NK T cell proliferation
relationship: negatively_regulates GO:0001866 ! NK T cell proliferation

[Term]
id: GO:0051142
name: positive regulation of NK T cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of natural killer T cell proliferation." [ISBN:0781735149, PMID:12154375, PMID:9133426]
synonym: "activation of NK T cell proliferation" NARROW []
synonym: "positive regulation of natural killer T cell proliferation" EXACT []
synonym: "positive regulation of natural T cell proliferation" EXACT []
synonym: "positive regulation of NK T lymphocyte proliferation" EXACT []
synonym: "positive regulation of NK T-cell proliferation" EXACT []
synonym: "positive regulation of NK T-lymphocyte proliferation" EXACT []
synonym: "positive regulation of NKT cell proliferation" EXACT []
synonym: "positive regulation of NT cell proliferation" EXACT []
synonym: "stimulation of NK T cell proliferation" NARROW []
synonym: "up regulation of NK T cell proliferation" EXACT []
synonym: "up-regulation of NK T cell proliferation" EXACT []
synonym: "upregulation of NK T cell proliferation" EXACT []
is_a: GO:0046641 ! positive regulation of alpha-beta T cell proliferation
is_a: GO:0051135 ! positive regulation of NK T cell activation
is_a: GO:0051140 ! regulation of NK T cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001866 ! NK T cell proliferation
relationship: positively_regulates GO:0001866 ! NK T cell proliferation

[Term]
id: GO:0051143
name: propanediol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving propanediol, CH3-CHOH-CH2OH, a sweet, colorless, viscous, hygroscopic liquid used as an antifreeze, in brake fluid and as a humectant in cosmetics and personal care items." [http://www.onelook.com]
subset: gosubset_prok
synonym: "1,2-dihydroxypropane metabolic process" EXACT []
synonym: "1,2-dihydroxypropane metabolism" EXACT []
synonym: "propanediol metabolism" EXACT []
synonym: "propylene glycol metabolic process" EXACT []
synonym: "propylene glycol metabolism" EXACT []
is_a: GO:0042844 ! glycol metabolic process

[Term]
id: GO:0051144
name: propanediol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of propanediol, a sweet, colorless, viscous, hygroscopic liquid with the formula CH3-CHOH-CH2OH." [GOC:ai]
subset: gosubset_prok
synonym: "1,2-dihydroxypropane catabolic process" EXACT []
synonym: "1,2-dihydroxypropane catabolism" EXACT []
synonym: "propanediol breakdown" EXACT []
synonym: "propanediol catabolism" EXACT []
synonym: "propanediol degradation" EXACT []
synonym: "propylene glycol catabolic process" EXACT []
synonym: "propylene glycol catabolism" EXACT []
is_a: GO:0042846 ! glycol catabolic process
is_a: GO:0051143 ! propanediol metabolic process

[Term]
id: GO:0051145
name: smooth muscle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary." [CL:0000192, GOC:ai]
synonym: "nonstriated muscle cell differentiation" EXACT []
is_a: GO:0042692 ! muscle cell differentiation

[Term]
id: GO:0051146
name: striated muscle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle." [CL:0000737, GOC:ai]
synonym: "voluntary muscle cell differentiation" NARROW []
is_a: GO:0042692 ! muscle cell differentiation

[Term]
id: GO:0051147
name: regulation of muscle cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai]
is_a: GO:0045595 ! regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042692 ! muscle cell differentiation
relationship: regulates GO:0042692 ! muscle cell differentiation

[Term]
id: GO:0051148
name: negative regulation of muscle cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai]
synonym: "down regulation of muscle cell differentiation" EXACT []
synonym: "down-regulation of muscle cell differentiation" EXACT []
synonym: "downregulation of muscle cell differentiation" EXACT []
synonym: "inhibition of muscle cell differentiation" NARROW []
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0051147 ! regulation of muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042692 ! muscle cell differentiation
relationship: negatively_regulates GO:0042692 ! muscle cell differentiation

[Term]
id: GO:0051149
name: positive regulation of muscle cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai]
synonym: "activation of muscle cell differentiation" NARROW []
synonym: "stimulation of muscle cell differentiation" NARROW []
synonym: "up regulation of muscle cell differentiation" EXACT []
synonym: "up-regulation of muscle cell differentiation" EXACT []
synonym: "upregulation of muscle cell differentiation" EXACT []
xref: Reactome:REACT_106354 "CDO in myogenesis, Gallus gallus"
xref: Reactome:REACT_113620 "CDO in myogenesis, Caenorhabditis elegans"
xref: Reactome:REACT_21402 "CDO in myogenesis, Homo sapiens"
xref: Reactome:REACT_33069 "CDO in myogenesis, Xenopus tropicalis"
xref: Reactome:REACT_77777 "CDO in myogenesis, Sus scrofa"
xref: Reactome:REACT_78092 "CDO in myogenesis, Drosophila melanogaster"
xref: Reactome:REACT_85123 "CDO in myogenesis, Danio rerio"
xref: Reactome:REACT_85269 "CDO in myogenesis, Taeniopygia guttata"
xref: Reactome:REACT_86878 "CDO in myogenesis, Bos taurus"
xref: Reactome:REACT_94854 "CDO in myogenesis, Rattus norvegicus"
xref: Reactome:REACT_96248 "CDO in myogenesis, Mus musculus"
xref: Reactome:REACT_97269 "CDO in myogenesis, Canis familiaris"
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0051147 ! regulation of muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042692 ! muscle cell differentiation
relationship: positively_regulates GO:0042692 ! muscle cell differentiation

[Term]
id: GO:0051150
name: regulation of smooth muscle cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of smooth muscle cell differentiation." [CL:0000192, GOC:ai]
is_a: GO:0051147 ! regulation of muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051145 ! smooth muscle cell differentiation
relationship: regulates GO:0051145 ! smooth muscle cell differentiation

[Term]
id: GO:0051151
name: negative regulation of smooth muscle cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell differentiation." [CL:0000192, GOC:ai]
synonym: "down regulation of smooth muscle cell differentiation" EXACT []
synonym: "down-regulation of smooth muscle cell differentiation" EXACT []
synonym: "downregulation of smooth muscle cell differentiation" EXACT []
synonym: "inhibition of smooth muscle cell differentiation" NARROW []
is_a: GO:0051148 ! negative regulation of muscle cell differentiation
is_a: GO:0051150 ! regulation of smooth muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051145 ! smooth muscle cell differentiation
relationship: negatively_regulates GO:0051145 ! smooth muscle cell differentiation

[Term]
id: GO:0051152
name: positive regulation of smooth muscle cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of smooth muscle cell differentiation." [CL:0000192, GOC:ai]
synonym: "activation of smooth muscle cell differentiation" NARROW []
synonym: "stimulation of smooth muscle cell differentiation" NARROW []
synonym: "up regulation of smooth muscle cell differentiation" EXACT []
synonym: "up-regulation of smooth muscle cell differentiation" EXACT []
synonym: "upregulation of smooth muscle cell differentiation" EXACT []
is_a: GO:0051149 ! positive regulation of muscle cell differentiation
is_a: GO:0051150 ! regulation of smooth muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051145 ! smooth muscle cell differentiation
relationship: positively_regulates GO:0051145 ! smooth muscle cell differentiation

[Term]
id: GO:0051153
name: regulation of striated muscle cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of striated muscle cell differentiation." [CL:0000737, GOC:ai]
is_a: GO:0051147 ! regulation of muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051146 ! striated muscle cell differentiation
relationship: regulates GO:0051146 ! striated muscle cell differentiation

[Term]
id: GO:0051154
name: negative regulation of striated muscle cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle cell differentiation." [CL:0000737, GOC:ai]
synonym: "down regulation of striated muscle cell differentiation" EXACT []
synonym: "down-regulation of striated muscle cell differentiation" EXACT []
synonym: "downregulation of striated muscle cell differentiation" EXACT []
synonym: "inhibition of striated muscle cell differentiation" NARROW []
is_a: GO:0051148 ! negative regulation of muscle cell differentiation
is_a: GO:0051153 ! regulation of striated muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051146 ! striated muscle cell differentiation
relationship: negatively_regulates GO:0051146 ! striated muscle cell differentiation

[Term]
id: GO:0051155
name: positive regulation of striated muscle cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of striated muscle cell differentiation." [CL:0000737, GOC:ai]
synonym: "activation of striated muscle cell differentiation" NARROW []
synonym: "stimulation of striated muscle cell differentiation" NARROW []
synonym: "up regulation of striated muscle cell differentiation" EXACT []
synonym: "up-regulation of striated muscle cell differentiation" EXACT []
synonym: "upregulation of striated muscle cell differentiation" EXACT []
is_a: GO:0051149 ! positive regulation of muscle cell differentiation
is_a: GO:0051153 ! regulation of striated muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051146 ! striated muscle cell differentiation
relationship: positively_regulates GO:0051146 ! striated muscle cell differentiation

[Term]
id: GO:0051156
name: glucose 6-phosphate metabolic process
namespace: biological_process
alt_id: GO:0006010
def: "The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-6." [GOC:ai]
subset: gosubset_prok
synonym: "glucose 6-phosphate metabolism" EXACT []
synonym: "glucose 6-phosphate utilization" RELATED [GOC:mah]
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:0051157
name: arabitol catabolic process
namespace: biological_process
alt_id: GO:0019591
def: "The chemical reactions and pathways resulting in the breakdown of arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group." [ISBN:0198506732]
subset: gosubset_prok
synonym: "arabitol breakdown" EXACT []
synonym: "arabitol catabolism" EXACT []
synonym: "arabitol degradation" EXACT []
synonym: "arabitol utilization" RELATED [GOC:mah]
is_a: GO:0019527 ! pentitol catabolic process
is_a: GO:0051161 ! arabitol metabolic process

[Term]
id: GO:0051158
name: L-arabitol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group." [ISBN:0198506732]
subset: gosubset_prok
synonym: "L-arabitol breakdown" EXACT []
synonym: "L-arabitol catabolism" EXACT []
synonym: "L-arabitol degradation" EXACT []
is_a: GO:0051157 ! arabitol catabolic process
is_a: GO:0051162 ! L-arabitol metabolic process

[Term]
id: GO:0051159
name: D-arabitol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. The D enantiomer is present in lichens and mushrooms." [ISBN:0198506732]
subset: gosubset_prok
synonym: "D-arabitol breakdown" EXACT []
synonym: "D-arabitol catabolism" EXACT []
synonym: "D-arabitol degradation" EXACT []
is_a: GO:0051157 ! arabitol catabolic process
is_a: GO:0051163 ! D-arabitol metabolic process

[Term]
id: GO:0051160
name: L-xylitol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-xylitol, a five-carbon sugar alcohol derived from xylose by reduction of the carbonyl group." [GOC:ai]
subset: gosubset_prok
synonym: "L-xylitol breakdown" EXACT []
synonym: "L-xylitol catabolism" EXACT []
synonym: "L-xylitol degradation" EXACT []
is_a: GO:0019527 ! pentitol catabolic process
is_a: GO:0051164 ! L-xylitol metabolic process

[Term]
id: GO:0051161
name: arabitol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group." [ISBN:0198506732]
subset: gosubset_prok
synonym: "arabitol metabolism" EXACT []
is_a: GO:0019519 ! pentitol metabolic process

[Term]
id: GO:0051162
name: L-arabitol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving L-arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group." [ISBN:0198506732]
subset: gosubset_prok
synonym: "L-arabitol metabolism" EXACT []
is_a: GO:0051161 ! arabitol metabolic process

[Term]
id: GO:0051163
name: D-arabitol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. The D enantiomer is present in lichens and mushrooms." [ISBN:0198506732]
subset: gosubset_prok
synonym: "D-arabitol metabolism" EXACT []
is_a: GO:0051161 ! arabitol metabolic process

[Term]
id: GO:0051164
name: L-xylitol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving L-xylitol, a five-carbon sugar alcohol derived from xylose by reduction of the carbonyl group. It is as sweet as sucrose and is used as a noncariogenic sweetner and as a sugar substitute in diabetic diets." [GOC:ai, http://www.onelook.com]
subset: gosubset_prok
synonym: "L-xylitol metabolism" EXACT []
is_a: GO:0019519 ! pentitol metabolic process

[Term]
id: GO:0051165
name: 2,5-dihydroxypyridine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 2,5-dihydroxypyridine." [CHEBI:16364, GOC:ai]
subset: gosubset_prok
synonym: "2,5-dihydroxypyridine metabolism" EXACT []
synonym: "pyridine-2,5-diol metabolic process" EXACT [CHEBI:16364]
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0072524 ! pyridine-containing compound metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process

[Term]
id: GO:0051166
name: 2,5-dihydroxypyridine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 2,5-dihydroxypyridine." [CHEBI:16364, GOC:ai]
subset: gosubset_prok
synonym: "2,5-dihydroxypyridine breakdown" EXACT []
synonym: "2,5-dihydroxypyridine catabolism" EXACT []
synonym: "2,5-dihydroxypyridine degradation" EXACT []
synonym: "pyridine-2,5-diol catabolic process" EXACT [CHEBI:16364]
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0051165 ! 2,5-dihydroxypyridine metabolic process
is_a: GO:0072526 ! pyridine-containing compound catabolic process
is_a: GO:1901616 ! organic hydroxy compound catabolic process

[Term]
id: GO:0051167
name: xylulose 5-phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving xylulose 5-phosphate, a derivative of the ketopentose xylulose phosphorylated at the 5 carbon; it is an intermediate in the pentose phosphate pathway." [ISBN:0721662544]
subset: gosubset_prok
synonym: "D-xylulose 5-phosphate metabolic process" EXACT []
synonym: "D-xylulose 5-phosphate metabolism" EXACT []
synonym: "D-xylulose-5-phosphate metabolic process" EXACT []
synonym: "D-xylulose-5-phosphate metabolism" EXACT []
synonym: "xylulose 5-phosphate metabolism" EXACT []
synonym: "xylulose-5-phosphate metabolic process" EXACT []
synonym: "xylulose-5-phosphate metabolism" EXACT []
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:0051168
name: nuclear export
namespace: biological_process
def: "The directed movement of substances out of the nucleus." [GOC:ai]
synonym: "export from nucleus" EXACT []
synonym: "nucleus export" EXACT []
synonym: "substance nuclear export" EXACT []
xref: Reactome:REACT_10069 "Nuclear export of snRNA transcripts, Homo sapiens"
xref: Reactome:REACT_103510 "Nuclear export of snRNA transcripts, Xenopus tropicalis"
xref: Reactome:REACT_112801 "Nuclear export of snRNA transcripts, Drosophila melanogaster"
xref: Reactome:REACT_113944 "Nuclear export of snRNA transcripts, Danio rerio"
xref: Reactome:REACT_31254 "Nuclear export of snRNA transcripts, Canis familiaris"
xref: Reactome:REACT_83378 "Nuclear export of snRNA transcripts, Gallus gallus"
xref: Reactome:REACT_89070 "Nuclear export of snRNA transcripts, Taeniopygia guttata"
xref: Reactome:REACT_92337 "Nuclear export of snRNA transcripts, Rattus norvegicus"
xref: Reactome:REACT_92521 "Nuclear export of snRNA transcripts, Sus scrofa"
xref: Reactome:REACT_92868 "Nuclear export of snRNA transcripts, Mus musculus"
xref: Reactome:REACT_96465 "Nuclear export of snRNA transcripts, Bos taurus"
is_a: GO:0006913 ! nucleocytoplasmic transport

[Term]
id: GO:0051169
name: nuclear transport
namespace: biological_process
def: "The directed movement of substances into, out of, or within the nucleus." [GOC:ai]
subset: goslim_yeast
synonym: "nucleus transport" EXACT []
xref: Reactome:REACT_9004 "Import of PIC to the Host Nucleus, Homo sapiens"
xref: Wikipedia:Nuclear_transport
is_a: GO:0046907 ! intracellular transport

[Term]
id: GO:0051170
name: nuclear import
namespace: biological_process
def: "The directed movement of substances into the nucleus." [GOC:ai]
synonym: "import into nucleus" EXACT []
synonym: "nucleus import" EXACT []
synonym: "substance nuclear import" EXACT []
xref: Reactome:REACT_10010 "snRNP nuclear import and release, Homo sapiens"
xref: Reactome:REACT_32050 "snRNP nuclear import and release, Xenopus tropicalis"
xref: Reactome:REACT_91459 "snRNP nuclear import and release, Mus musculus"
xref: Reactome:REACT_97007 "snRNP nuclear import and release, Danio rerio"
is_a: GO:0006913 ! nucleocytoplasmic transport

[Term]
id: GO:0051171
name: regulation of nitrogen compound metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." [GOC:ai, GOC:tb]
subset: gosubset_prok
synonym: "regulation of nitrogen metabolic process" EXACT [GOC:tb]
synonym: "regulation of nitrogen metabolism" EXACT []
is_a: GO:0019222 ! regulation of metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006807 ! nitrogen compound metabolic process
relationship: regulates GO:0006807 ! nitrogen compound metabolic process

[Term]
id: GO:0051172
name: negative regulation of nitrogen compound metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." [GOC:ai, GOC:tb]
synonym: "down regulation of nitrogen metabolic process" EXACT []
synonym: "down-regulation of nitrogen metabolic process" EXACT []
synonym: "downregulation of nitrogen metabolic process" EXACT []
synonym: "inhibition of nitrogen metabolic process" NARROW []
synonym: "negative regulation of nitrogen metabolic process" EXACT [GOC:tb]
synonym: "negative regulation of nitrogen metabolism" EXACT []
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006807 ! nitrogen compound metabolic process
relationship: negatively_regulates GO:0006807 ! nitrogen compound metabolic process

[Term]
id: GO:0051173
name: positive regulation of nitrogen compound metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." [GOC:ai, GOC:tb]
synonym: "activation of nitrogen metabolic process" NARROW []
synonym: "positive regulation of nitrogen metabolic process" EXACT [GOC:tb]
synonym: "positive regulation of nitrogen metabolism" EXACT []
synonym: "stimulation of nitrogen metabolic process" NARROW []
synonym: "up regulation of nitrogen metabolic process" EXACT []
synonym: "up-regulation of nitrogen metabolic process" EXACT []
synonym: "upregulation of nitrogen metabolic process" EXACT []
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006807 ! nitrogen compound metabolic process
relationship: positively_regulates GO:0006807 ! nitrogen compound metabolic process

[Term]
id: GO:0051174
name: regulation of phosphorus metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:ai]
subset: gosubset_prok
synonym: "regulation of phosphorus metabolism" EXACT []
is_a: GO:0031323 ! regulation of cellular metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006793 ! phosphorus metabolic process
relationship: regulates GO:0006793 ! phosphorus metabolic process

[Term]
id: GO:0051175
name: negative regulation of sulfur metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving sulfur or compounds containing sulfur." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of sulfur metabolic process" EXACT []
synonym: "down-regulation of sulfur metabolic process" EXACT []
synonym: "downregulation of sulfur metabolic process" EXACT []
synonym: "inhibition of sulfur metabolic process" NARROW []
synonym: "negative regulation of sulfur metabolism" EXACT []
synonym: "negative regulation of sulphur metabolic process" EXACT []
synonym: "negative regulation of sulphur metabolism" EXACT []
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006790 ! sulfur compound metabolic process
relationship: negatively_regulates GO:0006790 ! sulfur compound metabolic process

[Term]
id: GO:0051176
name: positive regulation of sulfur metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving sulfur or compounds containing sulfur." [GOC:ai]
subset: gosubset_prok
synonym: "activation of sulfur metabolic process" NARROW []
synonym: "positive regulation of sulfur metabolism" EXACT []
synonym: "positive regulation of sulphur metabolic process" EXACT []
synonym: "positive regulation of sulphur metabolism" EXACT []
synonym: "stimulation of sulfur metabolic process" NARROW []
synonym: "up regulation of sulfur metabolic process" EXACT []
synonym: "up-regulation of sulfur metabolic process" EXACT []
synonym: "upregulation of sulfur metabolic process" EXACT []
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006790 ! sulfur compound metabolic process
relationship: positively_regulates GO:0006790 ! sulfur compound metabolic process

[Term]
id: GO:0051177
name: meiotic sister chromatid cohesion
namespace: biological_process
def: "The cell cycle process in which sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during meiosis." [GOC:ai]
is_a: GO:0007062 ! sister chromatid cohesion
is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle
relationship: part_of GO:0045144 ! meiotic sister chromatid segregation

[Term]
id: GO:0051178
name: meiotic chromosome decondensation
namespace: biological_process
def: "The cell cycle process in which chromosome structure is altered from the condensed form held during meiosis to the relaxed dispersed form held in resting cells." [GOC:ai]
is_a: GO:0051312 ! chromosome decondensation
is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle
intersection_of: GO:0051312 ! chromosome decondensation
intersection_of: part_of GO:0051321 ! meiotic cell cycle
relationship: part_of GO:0045132 ! meiotic chromosome segregation
relationship: part_of GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0051179
name: localization
namespace: biological_process
def: "Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to or maintained in a specific location." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "establishment and maintenance of cellular component location" NARROW []
synonym: "establishment and maintenance of localization" EXACT []
synonym: "establishment and maintenance of position" EXACT []
synonym: "establishment and maintenance of substance location" NARROW []
synonym: "establishment and maintenance of substrate location" NARROW []
synonym: "localisation" EXACT [GOC:mah]
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0051180
name: vitamin transport
namespace: biological_process
def: "The directed movement of vitamins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "vitamin or cofactor transport" BROAD []
is_a: GO:0044765 ! single-organism transport

[Term]
id: GO:0051181
name: cofactor transport
namespace: biological_process
def: "The directed movement of a cofactor into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A cofactor is a substance that is required for the activity of an enzyme or other protein." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "vitamin or cofactor transport" BROAD []
is_a: GO:0044765 ! single-organism transport

[Term]
id: GO:0051182
name: coenzyme transport
namespace: biological_process
def: "The directed movement of a coenzyme into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A coenzyme is any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [GOC:ai]
is_a: GO:0051181 ! cofactor transport

[Term]
id: GO:0051183
name: vitamin transporter activity
namespace: molecular_function
def: "Enables the directed movement of vitamins into, out of or within a cell, or between cells. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]
subset: gosubset_prok
synonym: "vitamin or cofactor transporter activity" BROAD []
is_a: GO:0005215 ! transporter activity
relationship: part_of GO:0051180 ! vitamin transport

[Term]
id: GO:0051184
name: cofactor transporter activity
namespace: molecular_function
def: "Enables the directed movement of a cofactor into, out of or within a cell, or between cells. A cofactor is a substance that is required for the activity of an enzyme or other protein." [GOC:ai]
subset: gosubset_prok
synonym: "vitamin or cofactor transporter activity" BROAD []
is_a: GO:0005215 ! transporter activity
relationship: part_of GO:0051181 ! cofactor transport

[Term]
id: GO:0051185
name: coenzyme transporter activity
namespace: molecular_function
def: "Enables the directed movement of a coenzyme into, out of or within a cell, or between cells. A coenzyme is any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [GOC:ai]
is_a: GO:0051184 ! cofactor transporter activity
relationship: part_of GO:0051182 ! coenzyme transport

[Term]
id: GO:0051186
name: cofactor metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate." [GOC:ai]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "cofactor metabolism" EXACT []
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0051187
name: cofactor catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a cofactor, a substance that is required for the activity of an enzyme or other protein." [GOC:ai]
subset: gosubset_prok
synonym: "cofactor breakdown" EXACT []
synonym: "cofactor catabolism" EXACT []
synonym: "cofactor degradation" EXACT []
is_a: GO:0044248 ! cellular catabolic process
is_a: GO:0051186 ! cofactor metabolic process

[Term]
id: GO:0051188
name: cofactor biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a cofactor, a substance that is required for the activity of an enzyme or other protein." [GOC:ai]
subset: gosubset_prok
synonym: "cofactor anabolism" EXACT []
synonym: "cofactor biosynthesis" EXACT []
synonym: "cofactor formation" EXACT []
synonym: "cofactor synthesis" EXACT []
is_a: GO:0044249 ! cellular biosynthetic process
is_a: GO:0051186 ! cofactor metabolic process

[Term]
id: GO:0051189
name: prosthetic group metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "coenzyme and prosthetic group metabolic process" BROAD []
synonym: "coenzyme and prosthetic group metabolism" BROAD []
synonym: "prosthetic group metabolism" EXACT []
is_a: GO:0051186 ! cofactor metabolic process
relationship: part_of GO:0044267 ! cellular protein metabolic process

[Term]
id: GO:0051190
name: prosthetic group catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein." [GOC:ai]
subset: gosubset_prok
synonym: "coenzyme and prosthetic group catabolic process" BROAD []
synonym: "coenzyme and prosthetic group catabolism" BROAD []
synonym: "prosthetic group breakdown" EXACT []
synonym: "prosthetic group catabolism" EXACT []
synonym: "prosthetic group degradation" EXACT []
is_a: GO:0051187 ! cofactor catabolic process
is_a: GO:0051189 ! prosthetic group metabolic process
relationship: part_of GO:0044257 ! cellular protein catabolic process

[Term]
id: GO:0051191
name: prosthetic group biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein." [GOC:ai]
subset: gosubset_prok
synonym: "coenzyme and prosthetic group biosynthesis" BROAD []
synonym: "coenzyme and prosthetic group biosynthetic process" BROAD []
synonym: "prosthetic group anabolism" EXACT []
synonym: "prosthetic group biosynthesis" EXACT []
synonym: "prosthetic group formation" EXACT []
synonym: "prosthetic group synthesis" EXACT []
is_a: GO:0051188 ! cofactor biosynthetic process
is_a: GO:0051189 ! prosthetic group metabolic process
relationship: part_of GO:0009059 ! macromolecule biosynthetic process

[Term]
id: GO:0051192
name: prosthetic group binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein." [GOC:ai, GOC:vw]
subset: gosubset_prok
is_a: GO:0048037 ! cofactor binding

[Term]
id: GO:0051193
name: regulation of cofactor metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a cofactor." [GOC:ai]
subset: gosubset_prok
synonym: "regulation of cofactor metabolism" EXACT []
is_a: GO:0031323 ! regulation of cellular metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051186 ! cofactor metabolic process
relationship: regulates GO:0051186 ! cofactor metabolic process

[Term]
id: GO:0051194
name: positive regulation of cofactor metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a cofactor." [GOC:ai]
subset: gosubset_prok
synonym: "activation of cofactor metabolic process" NARROW []
synonym: "positive regulation of cofactor metabolism" EXACT []
synonym: "stimulation of cofactor metabolic process" NARROW []
synonym: "up regulation of cofactor metabolic process" EXACT []
synonym: "up-regulation of cofactor metabolic process" EXACT []
synonym: "upregulation of cofactor metabolic process" EXACT []
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0051193 ! regulation of cofactor metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051186 ! cofactor metabolic process
relationship: positively_regulates GO:0051186 ! cofactor metabolic process

[Term]
id: GO:0051195
name: negative regulation of cofactor metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a cofactor." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of cofactor metabolic process" EXACT []
synonym: "down-regulation of cofactor metabolic process" EXACT []
synonym: "downregulation of cofactor metabolic process" EXACT []
synonym: "inhibition of cofactor metabolic process" NARROW []
synonym: "negative regulation of cofactor metabolism" EXACT []
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0051193 ! regulation of cofactor metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051186 ! cofactor metabolic process
relationship: negatively_regulates GO:0051186 ! cofactor metabolic process

[Term]
id: GO:0051196
name: regulation of coenzyme metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme." [GOC:ai]
subset: gosubset_prok
synonym: "regulation of coenzyme and prosthetic group metabolic process" BROAD []
synonym: "regulation of coenzyme and prosthetic group metabolism" BROAD []
synonym: "regulation of coenzyme metabolism" EXACT []
is_a: GO:0051193 ! regulation of cofactor metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006732 ! coenzyme metabolic process
relationship: regulates GO:0006732 ! coenzyme metabolic process

[Term]
id: GO:0051197
name: positive regulation of coenzyme metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme." [GOC:ai]
subset: gosubset_prok
synonym: "activation of coenzyme metabolic process" NARROW []
synonym: "positive regulation of coenzyme and prosthetic group metabolic process" BROAD []
synonym: "positive regulation of coenzyme and prosthetic group metabolism" BROAD []
synonym: "positive regulation of coenzyme metabolism" EXACT []
synonym: "stimulation of coenzyme metabolic process" NARROW []
synonym: "up regulation of coenzyme metabolic process" EXACT []
synonym: "up-regulation of coenzyme metabolic process" EXACT []
synonym: "upregulation of coenzyme metabolic process" EXACT []
is_a: GO:0051194 ! positive regulation of cofactor metabolic process
is_a: GO:0051196 ! regulation of coenzyme metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006732 ! coenzyme metabolic process
relationship: positively_regulates GO:0006732 ! coenzyme metabolic process

[Term]
id: GO:0051198
name: negative regulation of coenzyme metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of coenzyme metabolic process" EXACT []
synonym: "down-regulation of coenzyme metabolic process" EXACT []
synonym: "downregulation of coenzyme metabolic process" EXACT []
synonym: "inhibition of coenzyme metabolic process" NARROW []
synonym: "negative regulation of coenzyme and prosthetic group metabolic process" BROAD []
synonym: "negative regulation of coenzyme and prosthetic group metabolism" BROAD []
synonym: "negative regulation of coenzyme metabolism" EXACT []
is_a: GO:0051195 ! negative regulation of cofactor metabolic process
is_a: GO:0051196 ! regulation of coenzyme metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006732 ! coenzyme metabolic process
relationship: negatively_regulates GO:0006732 ! coenzyme metabolic process

[Term]
id: GO:0051199
name: regulation of prosthetic group metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a prosthetic group." [GOC:ai]
subset: gosubset_prok
synonym: "regulation of coenzyme and prosthetic group metabolic process" BROAD []
synonym: "regulation of coenzyme and prosthetic group metabolism" BROAD []
synonym: "regulation of prosthetic group metabolism" EXACT []
is_a: GO:0032268 ! regulation of cellular protein metabolic process
is_a: GO:0051193 ! regulation of cofactor metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051189 ! prosthetic group metabolic process
relationship: regulates GO:0051189 ! prosthetic group metabolic process

[Term]
id: GO:0051200
name: positive regulation of prosthetic group metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a prosthetic group." [GOC:ai]
subset: gosubset_prok
synonym: "activation of prosthetic group metabolic process" NARROW []
synonym: "positive regulation of coenzyme and prosthetic group metabolic process" BROAD []
synonym: "positive regulation of coenzyme and prosthetic group metabolism" BROAD []
synonym: "positive regulation of prosthetic group metabolism" EXACT []
synonym: "stimulation of prosthetic group metabolic process" NARROW []
synonym: "up regulation of prosthetic group metabolic process" EXACT []
synonym: "up-regulation of prosthetic group metabolic process" EXACT []
synonym: "upregulation of prosthetic group metabolic process" EXACT []
is_a: GO:0032270 ! positive regulation of cellular protein metabolic process
is_a: GO:0051194 ! positive regulation of cofactor metabolic process
is_a: GO:0051199 ! regulation of prosthetic group metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051189 ! prosthetic group metabolic process
relationship: positively_regulates GO:0051189 ! prosthetic group metabolic process

[Term]
id: GO:0051201
name: negative regulation of prosthetic group metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a prosthetic group." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of prosthetic group metabolic process" EXACT []
synonym: "down-regulation of prosthetic group metabolic process" EXACT []
synonym: "downregulation of prosthetic group metabolic process" EXACT []
synonym: "inhibition of prosthetic group metabolic process" NARROW []
synonym: "negative regulation of coenzyme and prosthetic group metabolic process" BROAD []
synonym: "negative regulation of coenzyme and prosthetic group metabolism" BROAD []
synonym: "negative regulation of prosthetic group metabolism" EXACT []
is_a: GO:0032269 ! negative regulation of cellular protein metabolic process
is_a: GO:0051195 ! negative regulation of cofactor metabolic process
is_a: GO:0051199 ! regulation of prosthetic group metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051189 ! prosthetic group metabolic process
relationship: negatively_regulates GO:0051189 ! prosthetic group metabolic process

[Term]
id: GO:0051202
name: phytochromobilin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phytochromobilin, the linear tetrapyrrole chromophore required for plant phytochrome photoactivity." [PMID:11500553]
subset: gosubset_prok
synonym: "phytochromobilin metabolism" EXACT []
is_a: GO:0033013 ! tetrapyrrole metabolic process
is_a: GO:0051186 ! cofactor metabolic process

[Term]
id: GO:0051203
name: peptidyl-aspartic acid reduction to form L-aspartyl aldehyde
namespace: biological_process
def: "The reduction of peptidyl-aspartic acid to form peptidyl-L-aspartyl aldehyde, as found photosystem II P680 chlorophyll A apoprotein." [PMID:15237995, RESID:AA0373]
comment: See also UniProtKB:P04160.
subset: gosubset_prok
synonym: "peptidyl-aspartic acid reduction to form L-aspartate-beta-semialdehyde" EXACT []
synonym: "peptidyl-aspartic acid reduction to form L-beta-formylalanine" EXACT []
xref: RESID:AA0373
is_a: GO:0018197 ! peptidyl-aspartic acid modification

[Term]
id: GO:0051204
name: protein insertion into mitochondrial membrane
namespace: biological_process
def: "The process that results in the incorporation of a protein into a mitochondrial membrane." [GOC:ai]
synonym: "integral mitochondrial membrane protein localization" EXACT []
synonym: "integral mitochondrial membrane protein positioning" EXACT []
synonym: "localization of protein in mitochondrial membrane" EXACT []
synonym: "positioning of protein in mitochondrial membrane" EXACT []
synonym: "protein insertion into mitochondrion membrane" EXACT []
synonym: "protein-mitochondrial membrane insertion" EXACT []
synonym: "protein-mitochondrion membrane insertion" EXACT []
is_a: GO:0007006 ! mitochondrial membrane organization
is_a: GO:0051205 ! protein insertion into membrane
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0072655 ! establishment of protein localization to mitochondrion
is_a: GO:1902578 ! single-organism localization
relationship: part_of GO:0070585 ! protein localization to mitochondrion

[Term]
id: GO:0051205
name: protein insertion into membrane
namespace: biological_process
def: "The process that results in the incorporation of a protein into a biological membrane.  Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers." [GOC:ai]
subset: gosubset_prok
synonym: "integral membrane protein localization" EXACT []
synonym: "integral membrane protein positioning" EXACT []
synonym: "membrane protein localization" EXACT []
synonym: "membrane protein positioning" EXACT []
synonym: "protein-membrane insertion" EXACT []
is_a: GO:0090150 ! establishment of protein localization to membrane
relationship: part_of GO:0034613 ! cellular protein localization
relationship: part_of GO:0044802 ! single-organism membrane organization

[Term]
id: GO:0051206
name: silicate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving silicates, the salts of silicic acids. Silicates are usually composed of silicon and oxygen (Si[x]O[y]), one or more metals, and possibly hydrogen. Types of silicate include unisilicates, metasilicates and hydrous silicates." [GOC:ai]
subset: gosubset_prok
synonym: "silicate metabolism" EXACT []
is_a: GO:0043436 ! oxoacid metabolic process

[Term]
id: GO:0051208
name: sequestering of calcium ion
namespace: biological_process
def: "The process of binding or confining calcium ions such that they are separated from other components of a biological system." [GOC:ai]
synonym: "calcium ion (Ca2+) retention" EXACT []
synonym: "calcium ion (Ca2+) sequestering" EXACT []
synonym: "calcium ion (Ca2+) sequestration" EXACT []
synonym: "calcium ion (Ca2+) storage" EXACT []
synonym: "calcium ion storage activity" RELATED []
synonym: "negative regulation of calcium ion (Ca2+) transport" RELATED []
synonym: "retention of calcium ion (Ca2+)" EXACT []
synonym: "sequestering of calcium ion (Ca2+)" EXACT []
synonym: "sequestration of calcium ion (Ca2+)" EXACT []
synonym: "storage of calcium ion (Ca2+)" EXACT []
is_a: GO:0051238 ! sequestering of metal ion
relationship: part_of GO:0006874 ! cellular calcium ion homeostasis

[Term]
id: GO:0051209
name: release of sequestered calcium ion into cytosol
namespace: biological_process
def: "The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment." [GOC:dph, GOC:hjd, GOC:mtg_lung, PMID:1814929]
synonym: "calcium ion (Ca2+) mobilization" BROAD []
synonym: "calcium mobilization" BROAD []
synonym: "cytoplasmic release of sequestered calcium ion (Ca2+)" BROAD []
synonym: "cytoplasmic release of stored calcium ion (Ca2+)" BROAD []
synonym: "cytosolic release of sequestered calcium ion (Ca2+)" EXACT []
synonym: "cytosolic release of stored calcium ion (Ca2+)" EXACT []
synonym: "release of sequestered calcium ion (Ca2+)" BROAD []
synonym: "release of sequestered calcium ion into cytoplasm" BROAD []
synonym: "release of stored calcium ion (Ca2+)" BROAD []
synonym: "release of stored calcium ion (Ca2+) into cytoplasm" BROAD []
synonym: "release of stored calcium ion (Ca2+) into cytosol" EXACT []
is_a: GO:0051283 ! negative regulation of sequestering of calcium ion
is_a: GO:0097553 ! calcium ion transmembrane import into cytosol

[Term]
id: GO:0051210
name: isotropic cell growth
namespace: biological_process
def: "The process in which a cell irreversibly increases in size uniformly in all directions. In general, a rounded cell morphology reflects isotropic cell growth." [GOC:ai, GOC:jid]
synonym: "uniform cell growth" RELATED []
is_a: GO:0016049 ! cell growth

[Term]
id: GO:0051211
name: anisotropic cell growth
namespace: biological_process
def: "The process in which a cell irreversibly increases in size in one or more axes, where the growth rate varies according to the direction of growth. Growth may be limited to a particular axis, axes, or to particular locations on the surface of the cell." [GOC:ai]
synonym: "non-isotropic cell growth" EXACT []
is_a: GO:0016049 ! cell growth

[Term]
id: GO:0051212
name: vanadium ion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with vanadium (V) ions." [GOC:ai]
subset: gosubset_prok
is_a: GO:0046914 ! transition metal ion binding

[Term]
id: GO:0051213
name: dioxygenase activity
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which both atoms of oxygen from one molecule of O2 are incorporated into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products." [DOI:10.1016/S0040-4020(03)00944-X, GOC:bf, http://www.onelook.com/]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0051214
name: RNA virus induced gene silencing
namespace: biological_process
def: "Gene silencing induced by RNA viruses leading to a sequence-specific degradation of target mRNAs or post-transcriptional gene silencing." [PMID:15165191]
synonym: "RNA VIGS" EXACT []
synonym: "RNA virus-induced gene silencing" EXACT []
is_a: GO:0009616 ! virus induced gene silencing

[Term]
id: GO:0051215
name: DNA virus induced gene silencing
namespace: biological_process
def: "Gene silencing induced by DNA viruses leading to a sequence-specific degradation of target mRNAs or post-transcriptional gene silencing." [PMID:15165191]
synonym: "DNA VIGS" EXACT []
synonym: "DNA virus-induced gene silencing" EXACT []
is_a: GO:0009616 ! virus induced gene silencing

[Term]
id: GO:0051216
name: cartilage development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [DOI:10.1371/journal.pone.0051070, GOC:cjm, http://www.onelook.com]
synonym: "cartilage biogenesis" EXACT []
synonym: "cartilage biosynthesis" EXACT []
synonym: "cartilage element development" EXACT []
synonym: "cartilage formation" EXACT []
synonym: "cartilage organ development" EXACT []
synonym: "chondrogenesis" EXACT []
xref: Wikipedia:Chondrogenesis
is_a: GO:0048513 ! animal organ development
relationship: part_of GO:0001501 ! skeletal system development
relationship: part_of GO:0061448 ! connective tissue development

[Term]
id: GO:0051217
name: molybdenum incorporation via L-aspartyl molybdenum bis(molybdopterin guanine dinucleotide)
namespace: biological_process
def: "The incorporation of molybdenum into a protein via L-aspartyl molybdenum bis(molybdopterin guanine dinucleotide)." [PDB:1Q16, PMID:12910261, RESID:AA0375]
subset: gosubset_prok
xref: RESID:AA0375
is_a: GO:0018197 ! peptidyl-aspartic acid modification
is_a: GO:0018315 ! molybdenum incorporation into molybdenum-molybdopterin complex

[Term]
id: GO:0051218
name: tungsten incorporation via L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide)
namespace: biological_process
def: "The incorporation of tungsten into a protein via L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide)." [PDB:1HOH, PMID:12220497, RESID:AA0376]
subset: gosubset_prok
xref: RESID:AA02376
is_a: GO:0042042 ! tungsten incorporation into tungsten-molybdopterin complex
is_a: GO:0050844 ! peptidyl-selenocysteine modification

[Term]
id: GO:0051219
name: phosphoprotein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a phosphorylated protein." [GOC:ai]
subset: goslim_chembl
synonym: "phosphorylated protein binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0051220
name: cytoplasmic sequestering of protein
namespace: biological_process
def: "The selective interaction of a protein with specific molecules in the cytoplasm, thereby inhibiting its transport into other areas of the cell." [GOC:ai]
synonym: "cytoplasmic retention of protein" EXACT []
synonym: "cytoplasmic sequestration of protein" EXACT []
synonym: "cytoplasmic storage of protein" EXACT []
synonym: "maintenance of protein location in cytoplasm" EXACT [GOC:dph, GOC:tb]
synonym: "retention of protein in cytoplasm" EXACT []
synonym: "sequestering of protein in cytoplasm" EXACT []
synonym: "sequestration of protein in cytoplasm" EXACT []
synonym: "storage of protein in cytoplasm" EXACT []
is_a: GO:0032507 ! maintenance of protein location in cell
intersection_of: GO:0045185 ! maintenance of protein location
intersection_of: occurs_in GO:0005737 ! cytoplasm
relationship: occurs_in GO:0005737 ! cytoplasm

[Term]
id: GO:0051221
name: tungsten incorporation into metallo-sulfur cluster
namespace: biological_process
def: "The incorporation of tungsten into a metallo-sulfur cluster." [GOC:ai]
subset: gosubset_prok
synonym: "tungsten incorporation into metallo-sulphur cluster" EXACT []
is_a: GO:0018282 ! metal incorporation into metallo-sulfur cluster

[Term]
id: GO:0051222
name: positive regulation of protein transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "activation of protein transport" NARROW []
synonym: "stimulation of protein transport" NARROW []
synonym: "up regulation of protein transport" EXACT []
synonym: "up-regulation of protein transport" EXACT []
synonym: "upregulation of protein transport" EXACT []
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:0051223 ! regulation of protein transport
is_a: GO:1904951 ! positive regulation of establishment of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0015031 ! protein transport
relationship: positively_regulates GO:0015031 ! protein transport

[Term]
id: GO:0051223
name: regulation of protein transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0051049 ! regulation of transport
is_a: GO:0070201 ! regulation of establishment of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0015031 ! protein transport
relationship: regulates GO:0015031 ! protein transport

[Term]
id: GO:0051224
name: negative regulation of protein transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "down regulation of protein transport" EXACT []
synonym: "down-regulation of protein transport" EXACT []
synonym: "downregulation of protein transport" EXACT []
synonym: "inhibition of protein transport" NARROW []
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:0051223 ! regulation of protein transport
is_a: GO:1904950 ! negative regulation of establishment of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0015031 ! protein transport
relationship: negatively_regulates GO:0015031 ! protein transport

[Term]
id: GO:0051225
name: spindle assembly
namespace: biological_process
alt_id: GO:0051226
alt_id: GO:0051227
def: "The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb]
synonym: "bipolar spindle biosynthesis" EXACT []
synonym: "bipolar spindle formation" EXACT []
synonym: "spindle biosynthesis" EXACT []
synonym: "spindle formation" EXACT []
is_a: GO:0006461 ! protein complex assembly
is_a: GO:0007051 ! spindle organization
is_a: GO:0070925 ! organelle assembly

[Term]
id: GO:0051228
name: mitotic spindle disassembly
namespace: biological_process
def: "The controlled breakdown of the spindle during a mitotic cell cycle." [GOC:ai]
synonym: "mitotic spindle breakdown" EXACT []
synonym: "mitotic spindle catabolism" EXACT []
synonym: "mitotic spindle degradation" EXACT []
synonym: "spindle breakdown during mitosis" EXACT []
synonym: "spindle degradation during mitosis" EXACT []
synonym: "spindle disassembly during mitosis" EXACT []
is_a: GO:0007052 ! mitotic spindle organization
is_a: GO:0051230 ! spindle disassembly
intersection_of: GO:0051230 ! spindle disassembly
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0051229
name: meiotic spindle disassembly
namespace: biological_process
def: "The controlled breakdown of the spindle during a meiotic cell cycle." [GOC:ai]
synonym: "meiotic spindle breakdown" EXACT []
synonym: "meiotic spindle catabolism" EXACT []
synonym: "meiotic spindle degradation" EXACT []
synonym: "spindle breakdown during meiosis" EXACT []
synonym: "spindle degradation during meiosis" EXACT []
synonym: "spindle disassembly during meiosis" EXACT []
is_a: GO:0000212 ! meiotic spindle organization
is_a: GO:0051230 ! spindle disassembly
intersection_of: GO:0051230 ! spindle disassembly
intersection_of: part_of GO:0051321 ! meiotic cell cycle
relationship: part_of GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0051230
name: spindle disassembly
namespace: biological_process
def: "The controlled breakdown of the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai]
synonym: "spindle breakdown" EXACT []
synonym: "spindle catabolism" EXACT []
synonym: "spindle degradation" EXACT []
is_a: GO:0007051 ! spindle organization
is_a: GO:0043241 ! protein complex disassembly
is_a: GO:1903008 ! organelle disassembly

[Term]
id: GO:0051231
name: spindle elongation
namespace: biological_process
def: "The cell cycle process in which the distance is lengthened between poles of the spindle." [GOC:ai]
is_a: GO:0007017 ! microtubule-based process
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0007051 ! spindle organization
relationship: part_of GO:0098813 ! nuclear chromosome segregation

[Term]
id: GO:0051232
name: meiotic spindle elongation
namespace: biological_process
def: "The lengthening of the distance between poles of the spindle during a meiotic cell cycle." [GOC:ai]
synonym: "spindle elongation during meiosis" EXACT []
is_a: GO:0051231 ! spindle elongation
is_a: GO:1903046 ! meiotic cell cycle process
intersection_of: GO:0051231 ! spindle elongation
intersection_of: part_of GO:0051321 ! meiotic cell cycle
relationship: part_of GO:0000212 ! meiotic spindle organization
relationship: part_of GO:0045132 ! meiotic chromosome segregation
relationship: part_of GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0051233
name: spindle midzone
namespace: cellular_component
def: "The area in the center of the spindle where the spindle microtubules from opposite poles overlap." [GOC:ai, PMID:15296749]
synonym: "central spindle" EXACT [PMID:14528012]
synonym: "spindle equator" EXACT []
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0005819 ! spindle

[Term]
id: GO:0051234
name: establishment of localization
namespace: biological_process
def: "The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "establishment of localisation" EXACT [GOC:mah]
is_a: GO:0051179 ! localization

[Term]
id: GO:0051235
name: maintenance of location
namespace: biological_process
def: "Any process in which a cell, substance or cellular entity, such as a protein complex or organelle, is maintained in a location and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb]
subset: gosubset_prok
synonym: "maintenance of localization" EXACT []
synonym: "retention" NARROW []
synonym: "sequestering" NARROW []
synonym: "storage" NARROW []
is_a: GO:0051179 ! localization
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0051236
name: establishment of RNA localization
namespace: biological_process
def: "The directed movement of RNA to a specific location." [GOC:ai]
synonym: "establishment of RNA localisation" EXACT [GOC:mah]
synonym: "RNA positioning" EXACT []
synonym: "RNA recruitment" EXACT []
is_a: GO:0051234 ! establishment of localization
relationship: part_of GO:0006403 ! RNA localization

[Term]
id: GO:0051237
name: maintenance of RNA location
namespace: biological_process
def: "Any process in which RNA is maintained in a location and prevented from moving elsewhere." [GOC:ai]
synonym: "maintenance of RNA localization" RELATED [GOC:dph, GOC:tb]
synonym: "RNA retention" EXACT []
is_a: GO:0051235 ! maintenance of location
relationship: part_of GO:0006403 ! RNA localization

[Term]
id: GO:0051238
name: sequestering of metal ion
namespace: biological_process
def: "The process of binding or confining metal ions such that they are separated from other components of a biological system." [GOC:ai]
subset: gosubset_prok
synonym: "metal ion retention" EXACT []
synonym: "metal ion sequestering" EXACT []
synonym: "metal ion sequestration" EXACT []
synonym: "metal ion storage" EXACT []
synonym: "retention of metal ion" EXACT []
synonym: "sequestration of metal ion" EXACT []
synonym: "storage of metal ion" EXACT []
is_a: GO:0051235 ! maintenance of location

[Term]
id: GO:0051239
name: regulation of multicellular organismal process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai, GOC:dph, GOC:tb]
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032501 ! multicellular organismal process
relationship: regulates GO:0032501 ! multicellular organismal process

[Term]
id: GO:0051240
name: positive regulation of multicellular organismal process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]
synonym: "activation of multicellular organismal process" NARROW []
synonym: "stimulation of multicellular organismal process" NARROW []
synonym: "up regulation of multicellular organismal process" EXACT []
synonym: "up-regulation of multicellular organismal process" EXACT []
synonym: "upregulation of multicellular organismal process" EXACT []
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032501 ! multicellular organismal process
relationship: positively_regulates GO:0032501 ! multicellular organismal process
relationship: positively_regulates GO:0044707 ! single-multicellular organism process

[Term]
id: GO:0051241
name: negative regulation of multicellular organismal process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]
synonym: "down regulation of multicellular organismal process" EXACT []
synonym: "down-regulation of multicellular organismal process" EXACT []
synonym: "downregulation of multicellular organismal process" EXACT []
synonym: "inhibition of multicellular organismal process" NARROW []
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032501 ! multicellular organismal process
relationship: negatively_regulates GO:0032501 ! multicellular organismal process
relationship: negatively_regulates GO:0044707 ! single-multicellular organism process

[Term]
id: GO:0051245
name: negative regulation of cellular defense response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of the cellular defense response." [GOC:ai]
synonym: "down regulation of cellular defense response" EXACT []
synonym: "down-regulation of cellular defense response" EXACT []
synonym: "downregulation of cellular defense response" EXACT []
synonym: "inhibition of cellular defense response" NARROW []
synonym: "negative regulation of cellular defence response" EXACT []
is_a: GO:0010185 ! regulation of cellular defense response
is_a: GO:0031348 ! negative regulation of defense response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006968 ! cellular defense response
relationship: negatively_regulates GO:0006968 ! cellular defense response

[Term]
id: GO:0051246
name: regulation of protein metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai]
subset: gosubset_prok
synonym: "regulation of protein metabolism" EXACT []
is_a: GO:0060255 ! regulation of macromolecule metabolic process
is_a: GO:0080090 ! regulation of primary metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019538 ! protein metabolic process
relationship: regulates GO:0019538 ! protein metabolic process

[Term]
id: GO:0051247
name: positive regulation of protein metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai]
subset: gosubset_prok
synonym: "activation of protein metabolic process" NARROW []
synonym: "positive regulation of protein metabolism" EXACT []
synonym: "stimulation of protein metabolic process" NARROW []
synonym: "up regulation of protein metabolic process" EXACT []
synonym: "up-regulation of protein metabolic process" EXACT []
synonym: "upregulation of protein metabolic process" EXACT []
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0051246 ! regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0019538 ! protein metabolic process
relationship: positively_regulates GO:0019538 ! protein metabolic process

[Term]
id: GO:0051248
name: negative regulation of protein metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of protein metabolic process" EXACT []
synonym: "down-regulation of protein metabolic process" EXACT []
synonym: "downregulation of protein metabolic process" EXACT []
synonym: "inhibition of protein metabolic process" NARROW []
synonym: "negative regulation of protein metabolism" EXACT []
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0051246 ! regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019538 ! protein metabolic process
relationship: negatively_regulates GO:0019538 ! protein metabolic process

[Term]
id: GO:0051249
name: regulation of lymphocyte activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lymphocyte activation." [GOC:ai]
is_a: GO:0002694 ! regulation of leukocyte activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0046649 ! lymphocyte activation
relationship: regulates GO:0046649 ! lymphocyte activation

[Term]
id: GO:0051250
name: negative regulation of lymphocyte activation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte activation." [GOC:ai]
synonym: "down regulation of lymphocyte activation" EXACT []
synonym: "down-regulation of lymphocyte activation" EXACT []
synonym: "downregulation of lymphocyte activation" EXACT []
synonym: "inhibition of lymphocyte activation" NARROW []
is_a: GO:0002695 ! negative regulation of leukocyte activation
is_a: GO:0051249 ! regulation of lymphocyte activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0046649 ! lymphocyte activation
relationship: negatively_regulates GO:0046649 ! lymphocyte activation

[Term]
id: GO:0051251
name: positive regulation of lymphocyte activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lymphocyte activation." [GOC:ai]
synonym: "activation of lymphocyte activation" NARROW []
synonym: "stimulation of lymphocyte activation" NARROW []
synonym: "up regulation of lymphocyte activation" EXACT []
synonym: "up-regulation of lymphocyte activation" EXACT []
synonym: "upregulation of lymphocyte activation" EXACT []
is_a: GO:0002696 ! positive regulation of leukocyte activation
is_a: GO:0051249 ! regulation of lymphocyte activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0046649 ! lymphocyte activation
relationship: positively_regulates GO:0046649 ! lymphocyte activation

[Term]
id: GO:0051252
name: regulation of RNA metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai]
subset: gosubset_prok
synonym: "regulation of RNA metabolism" EXACT []
is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process
is_a: GO:0060255 ! regulation of macromolecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016070 ! RNA metabolic process
relationship: regulates GO:0016070 ! RNA metabolic process

[Term]
id: GO:0051253
name: negative regulation of RNA metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of RNA metabolic process" EXACT []
synonym: "down-regulation of RNA metabolic process" EXACT []
synonym: "downregulation of RNA metabolic process" EXACT []
synonym: "inhibition of RNA metabolic process" NARROW []
synonym: "negative regulation of RNA metabolism" EXACT []
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process
is_a: GO:0051252 ! regulation of RNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016070 ! RNA metabolic process
relationship: negatively_regulates GO:0016070 ! RNA metabolic process

[Term]
id: GO:0051254
name: positive regulation of RNA metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai]
subset: gosubset_prok
synonym: "activation of RNA metabolic process" NARROW []
synonym: "positive regulation of RNA metabolism" EXACT []
synonym: "stimulation of RNA metabolic process" NARROW []
synonym: "up regulation of RNA metabolic process" EXACT []
synonym: "up-regulation of RNA metabolic process" EXACT []
synonym: "upregulation of RNA metabolic process" EXACT []
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process
is_a: GO:0051252 ! regulation of RNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016070 ! RNA metabolic process
relationship: positively_regulates GO:0016070 ! RNA metabolic process

[Term]
id: GO:0051255
name: spindle midzone assembly
namespace: biological_process
def: "The cell cycle process in which aggregation, arrangement and bonding together of a set of components to form the spindle midzone. The spindle midzone is the area in the center of the spindle where the spindle microtubules from opposite poles overlap." [GOC:ai, PMID:15296749]
synonym: "spindle midzone biogenesis" EXACT []
synonym: "spindle midzone biosynthesis" EXACT []
synonym: "spindle midzone formation" EXACT []
is_a: GO:0007017 ! microtubule-based process
is_a: GO:0022402 ! cell cycle process
is_a: GO:0022607 ! cellular component assembly
relationship: part_of GO:0051225 ! spindle assembly

[Term]
id: GO:0051256
name: mitotic spindle midzone assembly
namespace: biological_process
def: "The cell cycle process in which the aggregation, arrangement and bonding together of a set of components forms the spindle midzone." [GOC:mtg_cell_cycle, GOC:vw, PMID:24239120]
synonym: "mitotic spindle midzone biogenesis" EXACT []
synonym: "mitotic spindle midzone biosynthesis" EXACT []
synonym: "mitotic spindle midzone formation" EXACT []
synonym: "spindle midzone assembly involved in mitosis" EXACT []
synonym: "spindle midzone biogenesis involved in mitosis" EXACT []
synonym: "spindle midzone formation involved in mitosis" EXACT []
is_a: GO:0051255 ! spindle midzone assembly
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0051255 ! spindle midzone assembly
intersection_of: part_of GO:0007067 ! mitotic nuclear division
relationship: part_of GO:0000022 ! mitotic spindle elongation
relationship: part_of GO:0007067 ! mitotic nuclear division
relationship: part_of GO:0090307 ! mitotic spindle assembly

[Term]
id: GO:0051257
name: meiotic spindle midzone assembly
namespace: biological_process
def: "The formation of the spindle midzone, the area in the center of the spindle where the spindle microtubules from opposite poles overlap, as a part of the process of meiosis." [GOC:ai, GOC:expert_rg, GOC:tb]
synonym: "meiotic spindle midzone biogenesis" EXACT []
synonym: "meiotic spindle midzone biosynthesis" EXACT []
synonym: "meiotic spindle midzone formation" EXACT []
synonym: "spindle midzone assembly involved in meiosis" EXACT []
synonym: "spindle midzone biogenesis involved in meiosis" EXACT []
synonym: "spindle midzone biosynthesis involved in meiosis" EXACT []
synonym: "spindle midzone formation involved in meiosis" EXACT []
is_a: GO:0051255 ! spindle midzone assembly
is_a: GO:1903046 ! meiotic cell cycle process
intersection_of: GO:0051255 ! spindle midzone assembly
intersection_of: part_of GO:0007126 ! meiotic nuclear division
relationship: part_of GO:0007126 ! meiotic nuclear division

[Term]
id: GO:0051258
name: protein polymerization
namespace: biological_process
def: "The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "protein polymer biosynthesis" EXACT []
synonym: "protein polymer biosynthetic process" EXACT []
synonym: "protein polymer formation" EXACT []
is_a: GO:0043623 ! cellular protein complex assembly

[Term]
id: GO:0051259
name: protein oligomerization
namespace: biological_process
def: "The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]
subset: gosubset_prok
synonym: "protein multimerization" RELATED [GOC:bf]
synonym: "protein oligomer assembly" EXACT []
synonym: "protein oligomer biosynthesis" EXACT []
synonym: "protein oligomer biosynthetic process" EXACT []
synonym: "protein oligomer formation" EXACT []
is_a: GO:0006461 ! protein complex assembly

[Term]
id: GO:0051260
name: protein homooligomerization
namespace: biological_process
def: "The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]
subset: gosubset_prok
synonym: "protein homooligomer assembly" EXACT []
synonym: "protein homooligomer biosynthesis" EXACT []
synonym: "protein homooligomer biosynthetic process" EXACT []
synonym: "protein homooligomer formation" EXACT []
synonym: "protein homooligomerization activity" RELATED []
is_a: GO:0051259 ! protein oligomerization

[Term]
id: GO:0051261
name: protein depolymerization
namespace: biological_process
def: "The process in which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "protein polymer breakdown" EXACT []
synonym: "protein polymer catabolic process" EXACT []
synonym: "protein polymer catabolism" EXACT []
synonym: "protein polymer degradation" EXACT []
is_a: GO:0043624 ! cellular protein complex disassembly

[Term]
id: GO:0051262
name: protein tetramerization
namespace: biological_process
def: "The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits." [GOC:ecd]
subset: gosubset_prok
synonym: "protein tetramer assembly" EXACT []
synonym: "protein tetramer biosynthesis" EXACT []
synonym: "protein tetramer biosynthetic process" EXACT []
synonym: "protein tetramer formation" EXACT []
is_a: GO:0051259 ! protein oligomerization

[Term]
id: GO:0051263
name: microcin E492 biosynthetic process by siderophore ester modification of peptidyl-serine
namespace: biological_process
def: "The modification of serine to N-[5-(6-O-seryl-beta-glucosyl)-2,3-dihydroxybenzoyl]-O-[N-(2,3-dihydroxybenzoyl)-O-[N-(2,3-dihydroxybenzoyl)seryl]seryl]serine as found in microcin E492 produced from the mceA gene in plasmid pJAM229 of the E. coli VCS257 strain and the K. pneumoniae RYC492 strain." [RESID:AA0374]
subset: gosubset_prok
synonym: "microcin E492 anabolism by siderophore ester modification of peptidyl-serine" EXACT []
synonym: "microcin E492 formation by siderophore ester modification of peptidyl-serine" EXACT []
synonym: "microcin E492 synthesis by siderophore ester modification of peptidyl-serine" EXACT []
xref: RESID:AA0374
is_a: GO:0018209 ! peptidyl-serine modification
is_a: GO:0018350 ! protein esterification

[Term]
id: GO:0051264
name: mono-olein transacylation activity
namespace: molecular_function
def: "Catalysis of the reaction: mono-olein + mono-olein = diolein + glycerol. Mono-olein, also known as mono-oleoylglycerol, is the monoglyceride formed from oleic acid, 9-octodecenoic acid; diolein is also known as dioleoylglycerol." [GOC:ai, PMID:15364929]
synonym: "acyl-CoA-independent mono-olein transacylation" EXACT []
synonym: "MOG transacylation" EXACT []
synonym: "mono-oleoylglycerol O-acyltransferase activity" EXACT []
synonym: "mono-oleoylglycerol transacylase activity" EXACT []
synonym: "monoolein transacylation" EXACT []
synonym: "monooleoylglycerol O-acyltransferase activity" EXACT []
synonym: "monooleoylglycerol transacylase activity" EXACT []
is_a: GO:0016411 ! acylglycerol O-acyltransferase activity

[Term]
id: GO:0051265
name: diolein transacylation activity
namespace: molecular_function
def: "Catalysis of the reaction: diolein + mono-olein = triolein + glycerol. Mono-olein, also known as mono-oleoylglycerol, is the monoglyceride formed from oleic acid, 9-octodecenoic acid; diolein is also known as dioleoylglycerol, and triolein as trioleoylglycerol and olein." [GOC:ai, PMID:15364929]
synonym: "acyl-CoA-independent diolein transacylation" EXACT []
synonym: "dioleoylglycerol O-acyltransferase activity" EXACT []
synonym: "dioleoylglycerol transacylase activity" EXACT []
synonym: "DOG transacylation" EXACT []
is_a: GO:0016411 ! acylglycerol O-acyltransferase activity

[Term]
id: GO:0051266
name: sirohydrochlorin ferrochelatase activity
namespace: molecular_function
def: "Catalysis of the reaction: siroheme + 2 H+ = Fe(2+) + sirohydrochlorin." [EC:4.99.1.4, RHEA:24363]
subset: gosubset_prok
synonym: "CysG" RELATED [EC:4.99.1.4]
synonym: "Met8P" RELATED [EC:4.99.1.4]
synonym: "SirB" RELATED [EC:4.99.1.4]
synonym: "siroheme ferro-lyase (sirohydrochlorin-forming)" EXACT [EC:4.99.1.4]
synonym: "siroheme synthase activity" BROAD []
synonym: "sirohydrochlorin ferro-lyase activity" EXACT []
xref: EC:4.99.1.4
xref: KEGG:R02864
xref: MetaCyc:SIROHEME-FERROCHELAT-RXN
xref: RHEA:24363
is_a: GO:0004325 ! ferrochelatase activity

[Term]
id: GO:0051267
name: CP2 mannose-ethanolamine phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ethanolamine phosphate + Man-alpha-(1,2)-Man-alpha-(1,2)-Man-alpha-(1,6)-R = Man-alpha-(1,2)-Man-alpha-6-P-EtN-(1,2)-Man-alpha-(1,6)-R; R is Man-alpha(1,4)-GlcNH2-inositol-PO4-lipid. This reaction is the transfer of ethanolamine phosphate to C6 of second mannose in the GPI lipid precursor CP2." [PMID:14985347, PMID:15452134]
synonym: "addition of ethanolamine phosphate to mannose of GPI precursor CP2" EXACT []
synonym: "CP2 ethanolamine phosphate transferase activity" EXACT []
synonym: "CP2 EtN-P transferase activity" EXACT []
synonym: "CP2 phosphoethanolamine transferase activity" EXACT []
synonym: "gpi7 activity" RELATED []
is_a: GO:0051377 ! mannose-ethanolamine phosphotransferase activity

[Term]
id: GO:0051268
name: alpha-keto amide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-keto amide + 2 H+ (from donor) = (R)-hydroxy amide. Alpha-keto amides are of the form R-CO-CONH2, where R may be aromatic or aliphatic." [GOC:ai, PMID:15564669]
xref: EC:1.2.-.-
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0051269
name: alpha-keto ester reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-keto ester + 2 H+ (from donor) = (R)-hydroxy ester. Alpha-keto esters are of the form R(1)-CO-CO-O-R(2), where the R groups may be aromatic or aliphatic." [GOC:ai, PMID:15564669]
xref: EC:1.2.-.-
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0051270
name: regulation of cellular component movement
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the movement of a cellular component." [GOC:ai, GOC:dph, GOC:jl]
subset: gosubset_prok
synonym: "regulation of cell movement" RELATED []
synonym: "regulation of cellular component motion" EXACT [GOC:mah]
is_a: GO:0032879 ! regulation of localization
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006928 ! movement of cell or subcellular component
relationship: regulates GO:0006928 ! movement of cell or subcellular component

[Term]
id: GO:0051271
name: negative regulation of cellular component movement
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of a cellular component." [GOC:ai, GOC:dph, GOC:jl]
subset: gosubset_prok
synonym: "down regulation of cell motility" EXACT []
synonym: "down-regulation of cell motility" EXACT []
synonym: "downregulation of cell motility" EXACT []
synonym: "inhibition of cell motility" NARROW []
synonym: "negative regulation of cell movement" RELATED []
synonym: "negative regulation of cellular component motion" EXACT [GOC:mah]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051270 ! regulation of cellular component movement
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006928 ! movement of cell or subcellular component
relationship: negatively_regulates GO:0006928 ! movement of cell or subcellular component

[Term]
id: GO:0051272
name: positive regulation of cellular component movement
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the movement of a cellular component." [GOC:ai, GOC:dph, GOC:jl]
subset: gosubset_prok
synonym: "activation of cell motility" NARROW []
synonym: "positive regulation of cell movement" RELATED []
synonym: "positive regulation of cellular component motion" EXACT [GOC:mah]
synonym: "stimulation of cell motility" NARROW []
synonym: "up regulation of cell motility" EXACT []
synonym: "up-regulation of cell motility" EXACT []
synonym: "upregulation of cell motility" EXACT []
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051270 ! regulation of cellular component movement
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006928 ! movement of cell or subcellular component
relationship: positively_regulates GO:0006928 ! movement of cell or subcellular component

[Term]
id: GO:0051273
name: beta-glucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds." [GOC:ai]
subset: gosubset_prok
synonym: "beta-glucan metabolism" EXACT []
is_a: GO:0006073 ! cellular glucan metabolic process

[Term]
id: GO:0051274
name: beta-glucan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of beta-glucans." [GOC:ai]
subset: gosubset_prok
synonym: "beta-glucan anabolism" EXACT []
synonym: "beta-glucan biosynthesis" EXACT []
synonym: "beta-glucan formation" EXACT []
synonym: "beta-glucan synthesis" EXACT []
is_a: GO:0009250 ! glucan biosynthetic process
is_a: GO:0051273 ! beta-glucan metabolic process

[Term]
id: GO:0051275
name: beta-glucan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of beta-glucans." [GOC:ai]
subset: gosubset_prok
synonym: "beta-glucan breakdown" EXACT []
synonym: "beta-glucan catabolism" EXACT []
synonym: "beta-glucan degradation" EXACT []
is_a: GO:0009251 ! glucan catabolic process
is_a: GO:0044247 ! cellular polysaccharide catabolic process
is_a: GO:0051273 ! beta-glucan metabolic process

[Term]
id: GO:0051276
name: chromosome organization
namespace: biological_process
alt_id: GO:0007001
alt_id: GO:0051277
def: "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_pir
subset: gosubset_prok
synonym: "chromosome organisation" EXACT []
synonym: "chromosome organization and biogenesis" RELATED [GOC:mah]
synonym: "maintenance of genome integrity" RELATED []
synonym: "nuclear genome maintenance" RELATED []
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0051278
name: fungal-type cell wall polysaccharide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the polysaccharides which make up the fungal-type cell wall." [GOC:ai, GOC:mtg_sensu]
synonym: "cell wall polysaccharide anabolism" BROAD []
synonym: "cell wall polysaccharide formation" BROAD []
synonym: "cell wall polysaccharide synthesis" BROAD []
synonym: "chitin- and beta-glucan-containing cell wall polysaccharide biosynthetic process" NARROW []
is_a: GO:0070592 ! cell wall polysaccharide biosynthetic process
is_a: GO:0071966 ! fungal-type cell wall polysaccharide metabolic process
relationship: part_of GO:0009272 ! fungal-type cell wall biogenesis

[Term]
id: GO:0051279
name: regulation of release of sequestered calcium ion into cytosol
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria." [GOC:ai, GOC:tb]
synonym: "regulation of calcium ion (Ca2+) mobilization" EXACT []
synonym: "regulation of calcium mobilization" EXACT []
synonym: "regulation of cytoplasmic release of sequestered calcium ion (Ca2+)" EXACT []
synonym: "regulation of cytoplasmic release of stored calcium ion (Ca2+)" EXACT []
synonym: "regulation of release of sequestered calcium ion (Ca2+)" BROAD []
synonym: "regulation of release of stored calcium ion (Ca2+)" BROAD []
synonym: "regulation of release of stored calcium ion (Ca2+) into cytoplasm" EXACT []
synonym: "regulation of release of stored calcium ion (Ca2+) into cytosol" EXACT []
is_a: GO:0010522 ! regulation of calcium ion transport into cytosol
is_a: GO:0051282 ! regulation of sequestering of calcium ion
is_a: GO:0090279 ! regulation of calcium ion import
is_a: GO:1903169 ! regulation of calcium ion transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051209 ! release of sequestered calcium ion into cytosol
relationship: regulates GO:0051209 ! release of sequestered calcium ion into cytosol

[Term]
id: GO:0051280
name: negative regulation of release of sequestered calcium ion into cytosol
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria." [GOC:ai]
synonym: "down regulation of release of sequestered calcium ion into cytosol" EXACT []
synonym: "down-regulation of release of sequestered calcium ion into cytosol" EXACT []
synonym: "downregulation of release of sequestered calcium ion into cytosol" EXACT []
synonym: "inhibition of release of sequestered calcium ion into cytosol" NARROW []
synonym: "negative regulation of calcium ion (Ca2+) mobilization" BROAD []
synonym: "negative regulation of calcium mobilization" BROAD []
synonym: "negative regulation of cytoplasmic release of sequestered calcium ion (Ca2+)" BROAD []
synonym: "negative regulation of cytoplasmic release of stored calcium ion (Ca2+)" BROAD []
synonym: "negative regulation of cytosolic release of sequestered calcium ion (Ca2+)" EXACT []
synonym: "negative regulation of cytosolic release of stored calcium ion (Ca2+)" EXACT []
synonym: "negative regulation of release of sequestered calcium ion (Ca2+)" BROAD []
synonym: "negative regulation of release of sequestered calcium ion into cytoplasm" BROAD []
synonym: "negative regulation of release of stored calcium ion (Ca2+)" BROAD []
synonym: "negative regulation of release of stored calcium ion (Ca2+) into cytoplasm" BROAD []
synonym: "negative regulation of release of stored calcium ion (Ca2+) into cytosol" EXACT []
is_a: GO:0010523 ! negative regulation of calcium ion transport into cytosol
is_a: GO:0051279 ! regulation of release of sequestered calcium ion into cytosol
is_a: GO:0051284 ! positive regulation of sequestering of calcium ion
is_a: GO:0090281 ! negative regulation of calcium ion import
is_a: GO:1903170 ! negative regulation of calcium ion transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051209 ! release of sequestered calcium ion into cytosol
relationship: negatively_regulates GO:0051209 ! release of sequestered calcium ion into cytosol

[Term]
id: GO:0051281
name: positive regulation of release of sequestered calcium ion into cytosol
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria." [GOC:ai]
synonym: "activation of release of sequestered calcium ion into cytosol" NARROW []
synonym: "positive regulation of calcium ion (Ca2+) mobilization" BROAD []
synonym: "positive regulation of calcium mobilization" BROAD []
synonym: "positive regulation of cytoplasmic release of sequestered calcium ion (Ca2+)" BROAD []
synonym: "positive regulation of cytoplasmic release of stored calcium ion (Ca2+)" BROAD []
synonym: "positive regulation of cytosolic release of sequestered calcium ion (Ca2+)" EXACT []
synonym: "positive regulation of cytosolic release of stored calcium ion (Ca2+)" EXACT []
synonym: "positive regulation of release of sequestered calcium ion (Ca2+)" BROAD []
synonym: "positive regulation of release of sequestered calcium ion into cytoplasm" BROAD []
synonym: "positive regulation of release of stored calcium ion (Ca2+)" BROAD []
synonym: "positive regulation of release of stored calcium ion (Ca2+) into cytoplasm" BROAD []
synonym: "positive regulation of release of stored calcium ion (Ca2+) into cytosol" EXACT []
synonym: "stimulation of release of sequestered calcium ion into cytosol" NARROW []
synonym: "up regulation of release of sequestered calcium ion into cytosol" EXACT []
synonym: "up-regulation of release of sequestered calcium ion into cytosol" EXACT []
synonym: "upregulation of release of sequestered calcium ion into cytosol" EXACT []
is_a: GO:0010524 ! positive regulation of calcium ion transport into cytosol
is_a: GO:0051279 ! regulation of release of sequestered calcium ion into cytosol
is_a: GO:0090280 ! positive regulation of calcium ion import
is_a: GO:1904427 ! positive regulation of calcium ion transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051209 ! release of sequestered calcium ion into cytosol
relationship: positively_regulates GO:0051209 ! release of sequestered calcium ion into cytosol

[Term]
id: GO:0051282
name: regulation of sequestering of calcium ion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system." [GOC:ai]
synonym: "regulation of calcium ion (Ca2+) retention" EXACT []
synonym: "regulation of calcium ion (Ca2+) sequestering" EXACT []
synonym: "regulation of calcium ion (Ca2+) sequestration" EXACT []
synonym: "regulation of calcium ion (Ca2+) storage" EXACT []
synonym: "regulation of retention of calcium ion (Ca2+)" EXACT []
synonym: "regulation of sequestering of calcium ion (Ca2+)" EXACT []
synonym: "regulation of sequestration of calcium ion (Ca2+)" EXACT []
synonym: "regulation of storage of calcium ion (Ca2+)" EXACT []
is_a: GO:0032879 ! regulation of localization
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:2000021 ! regulation of ion homeostasis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051208 ! sequestering of calcium ion
relationship: regulates GO:0051208 ! sequestering of calcium ion

[Term]
id: GO:0051283
name: negative regulation of sequestering of calcium ion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system." [GOC:ai]
synonym: "down regulation of sequestering of calcium ion" EXACT []
synonym: "down-regulation of sequestering of calcium ion" EXACT []
synonym: "downregulation of sequestering of calcium ion" EXACT []
synonym: "inhibition of sequestering of calcium ion" NARROW []
synonym: "negative regulation of calcium ion (Ca2+) retention" EXACT []
synonym: "negative regulation of calcium ion (Ca2+) sequestering" EXACT []
synonym: "negative regulation of calcium ion (Ca2+) sequestration" EXACT []
synonym: "negative regulation of calcium ion (Ca2+) storage" EXACT []
synonym: "negative regulation of retention of calcium ion (Ca2+)" EXACT []
synonym: "negative regulation of sequestering of calcium ion (Ca2+)" EXACT []
synonym: "negative regulation of sequestration of calcium ion (Ca2+)" EXACT []
synonym: "negative regulation of storage of calcium ion (Ca2+)" EXACT []
is_a: GO:0032845 ! negative regulation of homeostatic process
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051282 ! regulation of sequestering of calcium ion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051208 ! sequestering of calcium ion
relationship: negatively_regulates GO:0051208 ! sequestering of calcium ion

[Term]
id: GO:0051284
name: positive regulation of sequestering of calcium ion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system." [GOC:ai]
synonym: "activation of sequestering of calcium ion" NARROW []
synonym: "positive regulation of calcium ion (Ca2+) retention" EXACT []
synonym: "positive regulation of calcium ion (Ca2+) sequestering" EXACT []
synonym: "positive regulation of calcium ion (Ca2+) sequestration" EXACT []
synonym: "positive regulation of calcium ion (Ca2+) storage" EXACT []
synonym: "positive regulation of retention of calcium ion (Ca2+)" EXACT []
synonym: "positive regulation of sequestering of calcium ion (Ca2+)" EXACT []
synonym: "positive regulation of sequestration of calcium ion (Ca2+)" EXACT []
synonym: "positive regulation of storage of calcium ion (Ca2+)" EXACT []
synonym: "stimulation of sequestering of calcium ion" NARROW []
synonym: "up regulation of sequestering of calcium ion" EXACT []
synonym: "up-regulation of sequestering of calcium ion" EXACT []
synonym: "upregulation of sequestering of calcium ion" EXACT []
is_a: GO:0032846 ! positive regulation of homeostatic process
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051282 ! regulation of sequestering of calcium ion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051208 ! sequestering of calcium ion
relationship: positively_regulates GO:0051208 ! sequestering of calcium ion

[Term]
id: GO:0051285
name: cell cortex of cell tip
namespace: cellular_component
def: "The region directly beneath the plasma membrane at the cell tip. The cell tip is the region at either end of the longest axis of a cylindrical or elongated cell." [GOC:ai]
synonym: "cell cortex of cell end" EXACT []
is_a: GO:0099738 ! cell cortex region
intersection_of: GO:0099738 ! cell cortex region
intersection_of: part_of GO:0051286 ! cell tip
relationship: part_of GO:0051286 ! cell tip

[Term]
id: GO:0051286
name: cell tip
namespace: cellular_component
def: "The region at the end of the longest axis of a cylindrical or elongated cell." [GOC:ai, GOC:mah]
comment: Note that this term differs from 'cell pole ; GO:0060187' in that it is applicable to the thin ends of elongated cells, such as the ends of axons or dendrites.
synonym: "cell end" EXACT [GOC:mah]
is_a: GO:0044464 ! cell part

[Term]
id: GO:0051287
name: NAD binding
namespace: molecular_function
alt_id: GO:0051288
def: "Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]
subset: goslim_chembl
synonym: "NAD or NADH binding" RELATED [GOC:mah]
synonym: "NAD+ or NADH binding" RELATED []
synonym: "nicotinamide adenine dinucleotide binding" EXACT []
is_a: GO:0000166 ! nucleotide binding
is_a: GO:0050662 ! coenzyme binding

[Term]
id: GO:0051289
name: protein homotetramerization
namespace: biological_process
def: "The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits." [GOC:go_curators]
subset: gosubset_prok
synonym: "protein homotetramer assembly" EXACT []
synonym: "protein homotetramer biosynthesis" EXACT []
synonym: "protein homotetramer biosynthetic process" EXACT []
synonym: "protein homotetramer formation" EXACT []
is_a: GO:0051260 ! protein homooligomerization
is_a: GO:0051262 ! protein tetramerization

[Term]
id: GO:0051290
name: protein heterotetramerization
namespace: biological_process
def: "The formation of a protein heterotetramer, a macromolecular structure consisting of four noncovalently associated subunits, of which not all are identical." [GOC:go_curators]
subset: gosubset_prok
synonym: "protein heterotetramer assembly" EXACT []
synonym: "protein heterotetramer biosynthesis" EXACT []
synonym: "protein heterotetramer biosynthetic process" EXACT []
synonym: "protein heterotetramer formation" EXACT []
is_a: GO:0051262 ! protein tetramerization
is_a: GO:0051291 ! protein heterooligomerization

[Term]
id: GO:0051291
name: protein heterooligomerization
namespace: biological_process
def: "The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]
subset: gosubset_prok
synonym: "protein heterooligomer assembly" EXACT []
synonym: "protein heterooligomer biosynthesis" EXACT []
synonym: "protein heterooligomer biosynthetic process" EXACT []
synonym: "protein heterooligomer formation" EXACT []
is_a: GO:0051259 ! protein oligomerization

[Term]
id: GO:0051292
name: nuclear pore complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a nuclear pore complex." [GOC:ai, GOC:mah]
synonym: "NPC assembly" EXACT []
synonym: "nuclear pore assembly" EXACT []
synonym: "nuclear pore biogenesis" EXACT []
synonym: "nuclear pore biosynthesis" EXACT []
synonym: "nuclear pore complex biogenesis" EXACT []
synonym: "nuclear pore complex biosynthesis" EXACT []
synonym: "nuclear pore complex formation" EXACT []
synonym: "nuclear pore formation" EXACT []
is_a: GO:0006999 ! nuclear pore organization
is_a: GO:0043623 ! cellular protein complex assembly
is_a: GO:0046931 ! pore complex assembly

[Term]
id: GO:0051293
name: establishment of spindle localization
namespace: biological_process
def: "The directed movement of the spindle to a specific location in the cell." [GOC:ai]
synonym: "establishment of spindle localisation" EXACT [GOC:mah]
synonym: "spindle positioning" EXACT []
is_a: GO:0000226 ! microtubule cytoskeleton organization
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0051653 ! spindle localization
is_a: GO:0051656 ! establishment of organelle localization

[Term]
id: GO:0051294
name: establishment of spindle orientation
namespace: biological_process
def: "Any process that set the alignment of spindle relative to other cellular structures." [GOC:ai]
synonym: "orienting of spindle" EXACT []
synonym: "spindle orientation" EXACT []
is_a: GO:0051293 ! establishment of spindle localization
relationship: part_of GO:0030010 ! establishment of cell polarity

[Term]
id: GO:0051295
name: establishment of meiotic spindle localization
namespace: biological_process
def: "The cell cycle process in which the directed movement of the meiotic spindle to a specific location in the cell occurs." [GOC:ai]
synonym: "establishment of meiotic spindle localisation" EXACT [GOC:mah]
synonym: "meiotic spindle positioning" EXACT []
synonym: "spindle positioning during meiosis" RELATED []
synonym: "spindle positioning involved in meiotic cell cycle" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051293 ! establishment of spindle localization
is_a: GO:1903046 ! meiotic cell cycle process
intersection_of: GO:0051293 ! establishment of spindle localization
intersection_of: part_of GO:0051321 ! meiotic cell cycle
relationship: part_of GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0051296
name: establishment of meiotic spindle orientation
namespace: biological_process
def: "Any process that set the alignment of meiotic spindle relative to other cellular structures." [GOC:ai]
synonym: "establishment of spindle orientation during meiosis" RELATED []
synonym: "establishment of spindle orientation involved in meiotic cell cycle" EXACT [GOC:dph, GOC:tb]
synonym: "meiotic spindle orientation" EXACT []
synonym: "orienting of meiotic spindle" EXACT []
is_a: GO:0051294 ! establishment of spindle orientation
is_a: GO:0051295 ! establishment of meiotic spindle localization
intersection_of: GO:0051294 ! establishment of spindle orientation
intersection_of: part_of GO:0051321 ! meiotic cell cycle
relationship: part_of GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0051297
name: centrosome organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
synonym: "centrosome organisation" EXACT [GOC:curators]
synonym: "centrosome organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0031023 ! microtubule organizing center organization

[Term]
id: GO:0051298
name: centrosome duplication
namespace: biological_process
def: "The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai]
synonym: "centrosome replication" EXACT []
is_a: GO:0022402 ! cell cycle process
is_a: GO:0051297 ! centrosome organization
is_a: GO:1902589 ! single-organism organelle organization
relationship: part_of GO:0007098 ! centrosome cycle

[Term]
id: GO:0051299
name: centrosome separation
namespace: biological_process
def: "The process in which duplicated centrosome components move away from each other. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle." [GOC:ai]
is_a: GO:0022402 ! cell cycle process
is_a: GO:0051297 ! centrosome organization
is_a: GO:1902589 ! single-organism organelle organization
relationship: part_of GO:0007098 ! centrosome cycle

[Term]
id: GO:0051300
name: spindle pole body organization
namespace: biological_process
alt_id: GO:0051426
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle pole body (SPB). The SPB is the microtubule organizing center in fungi, and is functionally homologous to the animal cell centrosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
synonym: "SPB maturation" RELATED [GOC:vw]
synonym: "SPB organization" EXACT []
synonym: "spindle pole body maturation" RELATED [GOC:vw]
synonym: "spindle pole body organisation" EXACT [GOC:curators]
synonym: "spindle pole body organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0022402 ! cell cycle process
is_a: GO:0031023 ! microtubule organizing center organization
is_a: GO:0071822 ! protein complex subunit organization
is_a: GO:1902589 ! single-organism organelle organization

[Term]
id: GO:0051301
name: cell division
namespace: biological_process
def: "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr]
comment: Note that this term differs from 'cytokinesis ; GO:0000910' in that cytokinesis does not include nuclear division.
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: gosubset_prok
xref: Wikipedia:Cell_division
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0051302
name: regulation of cell division
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051301 ! cell division
relationship: regulates GO:0051301 ! cell division

[Term]
id: GO:0051303
name: establishment of chromosome localization
namespace: biological_process
def: "The directed movement of a chromosome to a specific location." [GOC:ai]
synonym: "chromosome positioning" EXACT []
synonym: "establishment of chromosome localisation" EXACT [GOC:mah]
is_a: GO:0050000 ! chromosome localization
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0051656 ! establishment of organelle localization

[Term]
id: GO:0051304
name: chromosome separation
namespace: biological_process
alt_id: GO:0034500
def: "The cell cycle process in which paired chromosomes are detached from each other. Chromosome separation begins with the release of cohesin complexes from chromosomes; in budding yeast, this includes the cleavage of cohesin complexes along the chromosome arms, followed by the separation of the centromeric regions. Chromosome separation also includes formation of chromatid axes mediated by condensins, and ends with the disentangling of inter-sister catenation catalyzed by topoisomerase II (topo II)." [GOC:ai, GOC:lb, GOC:mah, GOC:mtg_cell_cycle, PMID:20352243]
synonym: "chromatid release" RELATED [GOC:lb, GOC:mah, PMID:20352243]
synonym: "rDNA separation" NARROW []
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0007059 ! chromosome segregation

[Term]
id: GO:0051305
name: chromosome movement towards spindle pole
namespace: biological_process
def: "The directed movement of chromosomes in the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes." [GOC:ai]
synonym: "chromosome migration to spindle pole" EXACT []
synonym: "chromosome movement" BROAD []
synonym: "chromosome movement to spindle pole" EXACT []
is_a: GO:0007018 ! microtubule-based movement
is_a: GO:0022402 ! cell cycle process
is_a: GO:0051303 ! establishment of chromosome localization
is_a: GO:1902580 ! single-organism cellular localization
relationship: part_of GO:0098813 ! nuclear chromosome segregation

[Term]
id: GO:0051306
name: mitotic sister chromatid separation
namespace: biological_process
def: "The process in which sister chromatids are physically detached from each other during mitosis." [GOC:ai]
synonym: "chromosome separation during mitosis" RELATED []
synonym: "mitotic chromosome separation" RELATED []
synonym: "mitotic sister chromatid resolution" EXACT [GOC:mah]
synonym: "sister chromatid separation during mitosis" EXACT []
is_a: GO:0051304 ! chromosome separation
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:0000070 ! mitotic sister chromatid segregation

[Term]
id: GO:0051307
name: meiotic chromosome separation
namespace: biological_process
def: "The process in which chromosomes are physically detached from each other during meiosis." [GOC:ai]
synonym: "chromosome separation during meiosis" EXACT []
synonym: "meiotic chromosome resolution" EXACT [GOC:mah]
is_a: GO:0051304 ! chromosome separation
is_a: GO:1903046 ! meiotic cell cycle process
intersection_of: GO:0051304 ! chromosome separation
intersection_of: part_of GO:0051321 ! meiotic cell cycle
relationship: part_of GO:0045132 ! meiotic chromosome segregation
relationship: part_of GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0051308
name: male meiosis chromosome separation
namespace: biological_process
def: "The process in which paired chromosomes are physically detached from each other during male meiosis." [GOC:ai]
synonym: "chromosome separation during male meiosis" EXACT []
synonym: "male meiosis chromosome resolution" EXACT [GOC:mah]
is_a: GO:0007060 ! male meiosis chromosome segregation
is_a: GO:0051307 ! meiotic chromosome separation
intersection_of: GO:0051304 ! chromosome separation
intersection_of: part_of GO:0007140 ! male meiosis
relationship: part_of GO:0007140 ! male meiosis

[Term]
id: GO:0051309
name: female meiosis chromosome separation
namespace: biological_process
def: "The process in which paired chromosomes are physically detached from each other during female meiosis." [GOC:ai]
synonym: "chromosome separation during female meiosis" EXACT []
synonym: "female meiosis chromosome resolution" EXACT [GOC:mah]
is_a: GO:0016321 ! female meiosis chromosome segregation
is_a: GO:0051307 ! meiotic chromosome separation
intersection_of: GO:0051304 ! chromosome separation
intersection_of: part_of GO:0007143 ! female meiotic division
relationship: part_of GO:0007143 ! female meiotic division

[Term]
id: GO:0051310
name: metaphase plate congression
namespace: biological_process
def: "The alignment of chromosomes at the metaphase plate (spindle equator), a plane halfway between the poles of the spindle." [GOC:ai]
synonym: "chromosome congression" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0051303 ! establishment of chromosome localization
relationship: part_of GO:0098813 ! nuclear chromosome segregation

[Term]
id: GO:0051311
name: meiotic metaphase plate congression
namespace: biological_process
def: "The cell cycle process in which chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the meiotic spindle, during meiosis." [GOC:ai]
synonym: "metaphase plate congression during meiosis" EXACT []
is_a: GO:0051310 ! metaphase plate congression
is_a: GO:1902580 ! single-organism cellular localization
is_a: GO:1903046 ! meiotic cell cycle process
intersection_of: GO:0051310 ! metaphase plate congression
intersection_of: part_of GO:0051321 ! meiotic cell cycle
relationship: part_of GO:0045132 ! meiotic chromosome segregation
relationship: part_of GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0051312
name: chromosome decondensation
namespace: biological_process
def: "The alteration of chromosome structure from the condensed form to a relaxed disperse form." [GOC:ai]
is_a: GO:0051276 ! chromosome organization

[Term]
id: GO:0051315
name: attachment of mitotic spindle microtubules to kinetochore
namespace: biological_process
alt_id: GO:0051314
def: "The cell cycle process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex during mitosis." [GOC:ai, GOC:clt, GOC:dph, GOC:tb, PMID:26258632, PMID:26705896]
comment: This class covers transient, lateral attachment to microtubules as well as stable, correctly oriented, end-on attachment (biorientation)
synonym: "attachment of spindle microtubules to kinetochore during mitosis" RELATED [GOC:dph, GOC:tb]
synonym: "attachment of spindle microtubules to kinetochore involved in mitosis" EXACT [GOC:dph, GOC:tb]
synonym: "attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation" EXACT []
synonym: "attachment of spindle microtubules to mitotic chromosome" EXACT []
synonym: "mitotic bipolar attachment" RELATED [GOC:vw]
is_a: GO:0008608 ! attachment of spindle microtubules to kinetochore
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0008608 ! attachment of spindle microtubules to kinetochore
intersection_of: part_of GO:0000070 ! mitotic sister chromatid segregation
relationship: part_of GO:0000070 ! mitotic sister chromatid segregation

[Term]
id: GO:0051316
name: attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation
namespace: biological_process
alt_id: GO:0051317
def: "The cell cycle process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex contributing to meiotic chromosome segregation." [GOC:ai, GOC:dph, GOC:tb]
synonym: "attachment of spindle microtubules to kinetochore during meiosis" RELATED []
synonym: "attachment of spindle microtubules to kinetochore during meiotic chromosome segregation" RELATED [GOC:dph, GOC:tb]
synonym: "attachment of spindle microtubules to meiotic chromosome" EXACT []
is_a: GO:0008608 ! attachment of spindle microtubules to kinetochore
is_a: GO:1903046 ! meiotic cell cycle process
intersection_of: GO:0008608 ! attachment of spindle microtubules to kinetochore
intersection_of: part_of GO:0045132 ! meiotic chromosome segregation
relationship: part_of GO:0045132 ! meiotic chromosome segregation

[Term]
id: GO:0051318
name: G1 phase
namespace: biological_process
def: "The cell cycle 'gap' phase which is the interval between the completion of DNA segregation (usually by mitosis or meiosis) and the beginning of DNA synthesis." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
xref: Wikipedia:G1_phase
is_a: GO:0022403 ! cell cycle phase
relationship: part_of GO:0051325 ! interphase

[Term]
id: GO:0051319
name: G2 phase
namespace: biological_process
def: "The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation (usually by mitosis or meiosis)." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
xref: Wikipedia:G2_phase
is_a: GO:0022403 ! cell cycle phase
relationship: part_of GO:0051325 ! interphase

[Term]
id: GO:0051320
name: S phase
namespace: biological_process
def: "The cell cycle phase, following G1, during which DNA synthesis takes place." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "S-phase" EXACT []
xref: Wikipedia:S_phase
is_a: GO:0022403 ! cell cycle phase
relationship: part_of GO:0051325 ! interphase

[Term]
id: GO:0051321
name: meiotic cell cycle
namespace: biological_process
def: "Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions." [GOC:ai]
subset: goslim_yeast
synonym: "meiosis" BROAD []
xref: Wikipedia:Meiosis
is_a: GO:0007049 ! cell cycle
is_a: GO:0044702 ! single organism reproductive process
intersection_of: GO:0007049 ! cell cycle
intersection_of: has_part GO:0007126 ! meiotic nuclear division
relationship: has_part GO:0007126 ! meiotic nuclear division
relationship: part_of GO:0000003 ! reproduction

[Term]
id: GO:0051322
name: anaphase
namespace: biological_process
def: "The cell cycle phase, following metaphase, during which the chromosomes separate and migrate towards the poles of the spindle." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
xref: Wikipedia:Anaphase
is_a: GO:0022403 ! cell cycle phase

[Term]
id: GO:0051323
name: metaphase
namespace: biological_process
def: "The cell cycle phase, following prophase or prometaphase in higher eukaryotes, during which chromosomes become aligned on the equatorial plate of the cell." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
xref: Wikipedia:Metaphase
is_a: GO:0022403 ! cell cycle phase
relationship: part_of GO:0000279 ! M phase

[Term]
id: GO:0051324
name: prophase
namespace: biological_process
def: "The cell cycle phase which is the first stage of M phase of meiosis and mitosis and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
xref: Wikipedia:Prophase
is_a: GO:0022403 ! cell cycle phase
relationship: part_of GO:0000279 ! M phase

[Term]
id: GO:0051325
name: interphase
namespace: biological_process
def: "The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when prophase of meiosis or mitosis begins. During interphase the cell readies itself for meiosis or mitosis and the replication of its DNA occurs." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "karyostasis" EXACT []
synonym: "resting phase" BROAD []
xref: Wikipedia:Interphase
is_a: GO:0022403 ! cell cycle phase

[Term]
id: GO:0051326
name: telophase
namespace: biological_process
def: "The cell cycle phase which follows anaphase during M phase of mitosis and meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts." [GOC:mtg_cell_cycle]
comment: note that this term should not be used for direct annotation. if you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic s-phase). to capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
xref: Wikipedia:Telophase
is_a: GO:0022403 ! cell cycle phase
relationship: part_of GO:0000279 ! M phase

[Term]
id: GO:0051327
name: meiotic M phase
namespace: biological_process
def: "A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a meiotic cell cycle." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "M phase of meiotic cell cycle" EXACT []
is_a: GO:0000279 ! M phase
is_a: GO:0098762 ! meiotic cell cycle phase
intersection_of: GO:0000279 ! M phase
intersection_of: happens_during GO:0051321 ! meiotic cell cycle
relationship: happens_during GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0051328
name: meiotic interphase
namespace: biological_process
def: "The cell cycle phase which begins after cytokinesis and ends when meiotic prophase begins. Meiotic cells have an interphase after each meiotic division, but only interphase I involves replication of the cell's DNA." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "interphase of meiotic cell cycle" EXACT []
is_a: GO:0051325 ! interphase
is_a: GO:0098762 ! meiotic cell cycle phase
intersection_of: GO:0051325 ! interphase
intersection_of: happens_during GO:0051321 ! meiotic cell cycle
relationship: happens_during GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0051329
name: mitotic interphase
namespace: biological_process
def: "The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when mitotic prophase begins. During interphase the cell readies itself for mitosis and the replication of its DNA occurs." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "interphase of mitotic cell cycle" EXACT []
is_a: GO:0051325 ! interphase
is_a: GO:0098763 ! mitotic cell cycle phase
intersection_of: GO:0051325 ! interphase
intersection_of: happens_during GO:0000278 ! mitotic cell cycle
relationship: happens_during GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0051330
name: meiotic G1 phase
namespace: biological_process
def: "The cell cycle 'gap' phase which is the interval between the completion of DNA segregation by meiosis and the beginning of DNA synthesis." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "G1 phase of meiotic cell cycle" EXACT []
is_a: GO:0051318 ! G1 phase
is_a: GO:0098762 ! meiotic cell cycle phase
relationship: part_of GO:0051328 ! meiotic interphase

[Term]
id: GO:0051331
name: meiotic G2 phase
namespace: biological_process
def: "The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation by meiosis." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "G2 phase of meiotic cell cycle" EXACT []
is_a: GO:0051319 ! G2 phase
is_a: GO:0098762 ! meiotic cell cycle phase
relationship: part_of GO:0051328 ! meiotic interphase

[Term]
id: GO:0051332
name: meiotic S phase
namespace: biological_process
def: "The cell cycle phase, following G1, during which DNA synthesis takes place as part of a meiotic cell cycle." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "S phase of meiotic cell cycle" EXACT []
synonym: "S-phase of meiotic cell cycle" EXACT []
is_a: GO:0051320 ! S phase
is_a: GO:0098762 ! meiotic cell cycle phase
relationship: part_of GO:0051328 ! meiotic interphase

[Term]
id: GO:0051333
name: meiotic nuclear envelope reassembly
namespace: biological_process
def: "The cell cycle process in which the reformation of the nuclear envelope during meiosis occurs." [GOC:ai]
is_a: GO:0031468 ! nuclear envelope reassembly
is_a: GO:1903046 ! meiotic cell cycle process
intersection_of: GO:0031468 ! nuclear envelope reassembly
intersection_of: part_of GO:0051321 ! meiotic cell cycle
relationship: part_of GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0051334
name: meiosis I nuclear envelope reassembly
namespace: biological_process
def: "The reformation of the nuclear envelope during meiosis I." [GOC:ai]
is_a: GO:0051333 ! meiotic nuclear envelope reassembly
intersection_of: GO:0031468 ! nuclear envelope reassembly
intersection_of: part_of GO:0007127 ! meiosis I
relationship: part_of GO:0007127 ! meiosis I

[Term]
id: GO:0051335
name: meiosis II nuclear envelope reassembly
namespace: biological_process
def: "The reformation of the nuclear envelope during meiosis II." [GOC:ai]
is_a: GO:0051333 ! meiotic nuclear envelope reassembly
intersection_of: GO:0031468 ! nuclear envelope reassembly
intersection_of: part_of GO:0007135 ! meiosis II
relationship: part_of GO:0007135 ! meiosis II

[Term]
id: GO:0051336
name: regulation of hydrolase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [EC:3.-.-.-, GOC:ai]
subset: gosubset_prok
synonym: "hydrolase regulator" EXACT []
is_a: GO:0050790 ! regulation of catalytic activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016787 ! hydrolase activity
relationship: regulates GO:0016787 ! hydrolase activity

[Term]
id: GO:0051337
name: amitosis
namespace: biological_process
def: "Nuclear division that occurs by simple constriction of the nucleus without chromosome condensation or spindle formation." [GOC:curators, ISBN:0721662544]
synonym: "direct nuclear division" EXACT []
synonym: "Remak nuclear division" EXACT []
is_a: GO:0000280 ! nuclear division

[Term]
id: GO:0051338
name: regulation of transferase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [EC:2.-.-.-, GOC:ai]
comment: This term is useful for grouping, but is too general for manual annotation. Please use a child term instead.
subset: gocheck_do_not_manually_annotate
subset: gosubset_prok
synonym: "transferase regulator" EXACT []
is_a: GO:0050790 ! regulation of catalytic activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016740 ! transferase activity
relationship: regulates GO:0016740 ! transferase activity

[Term]
id: GO:0051339
name: regulation of lyase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, GOC:ai]
subset: gosubset_prok
synonym: "lyase regulator" EXACT []
is_a: GO:0050790 ! regulation of catalytic activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016829 ! lyase activity
relationship: regulates GO:0016829 ! lyase activity

[Term]
id: GO:0051340
name: regulation of ligase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6." [EC:6.-.-.-, GOC:ai]
subset: gosubset_prok
synonym: "ligase regulator" EXACT []
is_a: GO:0050790 ! regulation of catalytic activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016874 ! ligase activity
relationship: regulates GO:0016874 ! ligase activity

[Term]
id: GO:0051341
name: regulation of oxidoreductase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [EC:1.-.-.-, GOC:ai]
subset: gosubset_prok
synonym: "oxidoreductase regulator" EXACT []
is_a: GO:0050790 ! regulation of catalytic activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016491 ! oxidoreductase activity
relationship: regulates GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0051342
name: regulation of cyclic-nucleotide phosphodiesterase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate." [EC:3.1.4.17, GOC:ai, GOC:tb]
synonym: "3',5' cyclic nucleotide phosphodiesterase regulator" EXACT []
synonym: "3',5'-cyclic-AMP phosphodiesterase regulator" NARROW []
synonym: "cAMP phosphodiesterase regulator" NARROW []
synonym: "phosphodiesterase regulator" RELATED []
synonym: "regulation of 3',5' cyclic nucleotide phosphodiesterase activity" EXACT []
synonym: "regulation of 3',5'-cyclic-AMP phosphodiesterase activity" NARROW []
synonym: "regulation of cAMP phosphodiesterase activity" NARROW []
synonym: "regulation of cGMP phosphodiesterase activity" NARROW [GOC:tb]
synonym: "regulation of cyclic nucleotide phosphodiesterase activity" EXACT [GOC:tb]
is_a: GO:0051336 ! regulation of hydrolase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004112 ! cyclic-nucleotide phosphodiesterase activity
relationship: regulates GO:0004112 ! cyclic-nucleotide phosphodiesterase activity

[Term]
id: GO:0051343
name: positive regulation of cyclic-nucleotide phosphodiesterase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate." [GOC:ai, GOC:tb]
synonym: "3',5' cyclic nucleotide phosphodiesterase activator" EXACT []
synonym: "3',5'-cyclic-AMP phosphodiesterase activator" NARROW []
synonym: "activation of cyclic nucleotide phosphodiesterase activity" NARROW []
synonym: "cAMP phosphodiesterase activator" NARROW []
synonym: "phosphodiesterase activator" RELATED []
synonym: "positive regulation of 3',5' cyclic nucleotide phosphodiesterase activity" EXACT []
synonym: "positive regulation of 3',5'-cyclic-AMP phosphodiesterase activity" NARROW []
synonym: "positive regulation of cAMP phosphodiesterase activity" NARROW []
synonym: "positive regulation of cGMP phosphodiesterase activity" NARROW [GOC:tb]
synonym: "positive regulation of cyclic nucleotide phosphodiesterase activity" EXACT [GOC:tb]
synonym: "stimulation of cyclic nucleotide phosphodiesterase activity" NARROW []
synonym: "up regulation of cyclic nucleotide phosphodiesterase activity" EXACT []
synonym: "up-regulation of cyclic nucleotide phosphodiesterase activity" EXACT []
synonym: "upregulation of cyclic nucleotide phosphodiesterase activity" EXACT []
is_a: GO:0051342 ! regulation of cyclic-nucleotide phosphodiesterase activity
is_a: GO:0051345 ! positive regulation of hydrolase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004112 ! cyclic-nucleotide phosphodiesterase activity
relationship: positively_regulates GO:0004112 ! cyclic-nucleotide phosphodiesterase activity

[Term]
id: GO:0051344
name: negative regulation of cyclic-nucleotide phosphodiesterase activity
namespace: biological_process
def: "Any process that stops or reduces the rate of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate." [GOC:ai, GOC:tb]
synonym: "3',5' cyclic nucleotide phosphodiesterase inhibitor" EXACT []
synonym: "3',5'-cyclic-AMP phosphodiesterase inhibitor" NARROW []
synonym: "cAMP phosphodiesterase inhibitor" NARROW []
synonym: "down regulation of cyclic nucleotide phosphodiesterase activity" EXACT []
synonym: "down-regulation of cyclic nucleotide phosphodiesterase activity" EXACT []
synonym: "downregulation of cyclic nucleotide phosphodiesterase activity" EXACT []
synonym: "inhibition of cyclic nucleotide phosphodiesterase activity" NARROW []
synonym: "negative regulation of 3',5' cyclic nucleotide phosphodiesterase activity" EXACT []
synonym: "negative regulation of 3',5'-cyclic-AMP phosphodiesterase activity" NARROW []
synonym: "negative regulation of cAMP phosphodiesterase activity" NARROW []
synonym: "negative regulation of cGMP phosphodiesterase activity" NARROW [GOC:tb]
synonym: "negative regulation of cyclic nucleotide phosphodiesterase activity" EXACT [GOC:tb]
synonym: "phosphodiesterase inhibitor" RELATED []
is_a: GO:0051342 ! regulation of cyclic-nucleotide phosphodiesterase activity
is_a: GO:0051346 ! negative regulation of hydrolase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004112 ! cyclic-nucleotide phosphodiesterase activity
relationship: negatively_regulates GO:0004112 ! cyclic-nucleotide phosphodiesterase activity

[Term]
id: GO:0051345
name: positive regulation of hydrolase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds." [GOC:ai]
subset: gosubset_prok
synonym: "activation of hydrolase activity" NARROW []
synonym: "hydrolase activator" EXACT []
synonym: "stimulation of hydrolase activity" NARROW []
synonym: "up regulation of hydrolase activity" EXACT []
synonym: "up-regulation of hydrolase activity" EXACT []
synonym: "upregulation of hydrolase activity" EXACT []
is_a: GO:0043085 ! positive regulation of catalytic activity
is_a: GO:0051336 ! regulation of hydrolase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016787 ! hydrolase activity
relationship: positively_regulates GO:0016787 ! hydrolase activity

[Term]
id: GO:0051346
name: negative regulation of hydrolase activity
namespace: biological_process
def: "Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of hydrolase activity" EXACT []
synonym: "down-regulation of hydrolase activity" EXACT []
synonym: "downregulation of hydrolase activity" EXACT []
synonym: "hydrolase inhibitor" EXACT []
synonym: "inhibition of hydrolase activity" NARROW []
is_a: GO:0043086 ! negative regulation of catalytic activity
is_a: GO:0051336 ! regulation of hydrolase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016787 ! hydrolase activity
relationship: negatively_regulates GO:0016787 ! hydrolase activity

[Term]
id: GO:0051347
name: positive regulation of transferase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor." [GOC:ai]
comment: This term is useful for grouping, but is too general for manual annotation. Please use a child term instead.
subset: gocheck_do_not_manually_annotate
subset: gosubset_prok
synonym: "activation of transferase activity" NARROW []
synonym: "stimulation of transferase activity" NARROW []
synonym: "transferase activator" EXACT []
synonym: "up regulation of transferase activity" EXACT []
synonym: "up-regulation of transferase activity" EXACT []
synonym: "upregulation of transferase activity" EXACT []
is_a: GO:0043085 ! positive regulation of catalytic activity
is_a: GO:0051338 ! regulation of transferase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016740 ! transferase activity
relationship: positively_regulates GO:0016740 ! transferase activity

[Term]
id: GO:0051348
name: negative regulation of transferase activity
namespace: biological_process
def: "Any process that stops or reduces the rate of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor." [GOC:ai]
comment: This term is useful for grouping, but is too general for manual annotation. Please use a child term instead.
subset: gocheck_do_not_manually_annotate
subset: gosubset_prok
synonym: "down regulation of transferase activity" EXACT []
synonym: "down-regulation of transferase activity" EXACT []
synonym: "downregulation of transferase activity" EXACT []
synonym: "inhibition of transferase activity" NARROW []
synonym: "transferase inhibitor" EXACT []
is_a: GO:0043086 ! negative regulation of catalytic activity
is_a: GO:0051338 ! regulation of transferase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016740 ! transferase activity
relationship: negatively_regulates GO:0016740 ! transferase activity

[Term]
id: GO:0051349
name: positive regulation of lyase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:ai]
synonym: "activation of lyase activity" NARROW []
synonym: "lyase activator" EXACT []
synonym: "stimulation of lyase activity" NARROW []
synonym: "up regulation of lyase activity" EXACT []
synonym: "up-regulation of lyase activity" EXACT []
synonym: "upregulation of lyase activity" EXACT []
is_a: GO:0043085 ! positive regulation of catalytic activity
is_a: GO:0051339 ! regulation of lyase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016829 ! lyase activity
relationship: positively_regulates GO:0016829 ! lyase activity

[Term]
id: GO:0051350
name: negative regulation of lyase activity
namespace: biological_process
def: "Any process that stops or reduces the rate of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:ai]
synonym: "down regulation of lyase activity" EXACT []
synonym: "down-regulation of lyase activity" EXACT []
synonym: "downregulation of lyase activity" EXACT []
synonym: "inhibition of lyase activity" NARROW []
synonym: "lyase inhibitor" EXACT []
is_a: GO:0043086 ! negative regulation of catalytic activity
is_a: GO:0051339 ! regulation of lyase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016829 ! lyase activity
relationship: negatively_regulates GO:0016829 ! lyase activity

[Term]
id: GO:0051351
name: positive regulation of ligase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "activation of ligase activity" NARROW []
synonym: "ligase activator" EXACT []
synonym: "stimulation of ligase activity" NARROW []
synonym: "up regulation of ligase activity" EXACT []
synonym: "up-regulation of ligase activity" EXACT []
synonym: "upregulation of ligase activity" EXACT []
is_a: GO:0043085 ! positive regulation of catalytic activity
is_a: GO:0051340 ! regulation of ligase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016874 ! ligase activity
relationship: positively_regulates GO:0016874 ! ligase activity

[Term]
id: GO:0051352
name: negative regulation of ligase activity
namespace: biological_process
def: "Any process that stops or reduces the rate of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of ligase activity" EXACT []
synonym: "down-regulation of ligase activity" EXACT []
synonym: "downregulation of ligase activity" EXACT []
synonym: "inhibition of ligase activity" NARROW []
synonym: "ligase inhibitor" EXACT []
is_a: GO:0043086 ! negative regulation of catalytic activity
is_a: GO:0051340 ! regulation of ligase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016874 ! ligase activity
relationship: negatively_regulates GO:0016874 ! ligase activity

[Term]
id: GO:0051353
name: positive regulation of oxidoreductase activity
namespace: biological_process
alt_id: GO:0009391
def: "Any process that activates or increases the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered." [GOC:ai]
subset: gosubset_prok
synonym: "activation of oxidoreductase activity" NARROW []
synonym: "oxidoreductase activator" EXACT []
synonym: "ribonucleotide reductase activating enzyme activity" NARROW []
synonym: "stimulation of oxidoreductase activity" NARROW []
synonym: "up regulation of oxidoreductase activity" EXACT []
synonym: "up-regulation of oxidoreductase activity" EXACT []
synonym: "upregulation of oxidoreductase activity" EXACT []
xref: EC:1.97.1.-
is_a: GO:0043085 ! positive regulation of catalytic activity
is_a: GO:0051341 ! regulation of oxidoreductase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016491 ! oxidoreductase activity
relationship: positively_regulates GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0051354
name: negative regulation of oxidoreductase activity
namespace: biological_process
def: "Any process that stops or reduces the rate of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of oxidoreductase activity" EXACT []
synonym: "down-regulation of oxidoreductase activity" EXACT []
synonym: "downregulation of oxidoreductase activity" EXACT []
synonym: "inhibition of oxidoreductase activity" NARROW []
synonym: "oxidoreductase inhibitor" EXACT []
is_a: GO:0043086 ! negative regulation of catalytic activity
is_a: GO:0051341 ! regulation of oxidoreductase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016491 ! oxidoreductase activity
relationship: negatively_regulates GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0051355
name: proprioception involved in equilibrioception
namespace: biological_process
def: "The series of events contributing to equilibrioception by which an organism senses the position, location, orientation, and movement of the body and its parts. Proprioception plays an important role in the ability of an organism to perceive its orientation with respect to gravity." [GOC:ai]
synonym: "equilibrioception by proprioception" EXACT []
synonym: "perception of orientation with respect to gravity by proprioception" EXACT []
synonym: "proprioception during equilibrioception" RELATED [GOC:dph, GOC:tb]
is_a: GO:0019230 ! proprioception
intersection_of: GO:0019230 ! proprioception
intersection_of: part_of GO:0050957 ! equilibrioception
relationship: part_of GO:0050957 ! equilibrioception

[Term]
id: GO:0051356
name: visual perception involved in equilibrioception
namespace: biological_process
def: "The series of events during equilibrioception required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual input plays an important role in the ability of an organism to perceive its orientation with respect to gravity." [GOC:ai]
synonym: "equilibrioception by visual perception" NARROW []
synonym: "perception of orientation with respect to gravity by visual perception" EXACT []
synonym: "visual perception during equilibrioception" RELATED [GOC:dph, GOC:tb]
is_a: GO:0007601 ! visual perception
intersection_of: GO:0007601 ! visual perception
intersection_of: part_of GO:0050957 ! equilibrioception
relationship: part_of GO:0050957 ! equilibrioception

[Term]
id: GO:0051357
name: peptide cross-linking via 3-(2-methylthio)ethyl-6-(4-hydroxybenzylidene)-5-iminopiperazin-2-one
namespace: biological_process
def: "The formation of a 2-keto-5-iminopiperazine protein chromophore cross-link from the alpha-amino nitrogen of residue n, a methionine, to the alpha-carboxyl carbon of residue n+1, a tyrosine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+2. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons." [PMID:10852900, PMID:11259412, PMID:15491166, RESID:AA0377]
comment: Note that this predicted modification is now thought not to exist. See the biological process term 'peptide cross-linking via 2-imino-methionine 5-imidazolinone glycine ; GO:0051359'.
synonym: "biosynthesis of protein-protein cross-link via L-methionyl-L-tyrosyl-2-keto-5-iminopiperazine" EXACT []
synonym: "biosynthetic process of protein-protein cross-link via L-methionyl-L-tyrosyl-2-keto-5-iminopiperazine" EXACT []
xref: RESID:AA0377
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018206 ! peptidyl-methionine modification
is_a: GO:0018212 ! peptidyl-tyrosine modification
is_a: GO:0018298 ! protein-chromophore linkage

[Term]
id: GO:0051358
name: peptide cross-linking via 2-imino-glutamic acid 5-imidazolinone glycine
namespace: biological_process
def: "The formation of the non-fluorescent protein chromophore cross-link from the alpha-carboxyl carbon of residue n, a glutamic acid, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons. This modification is found in the GFP-like non-fluorescent red chromoprotein from the sea anemone Radianthus macrodactylus." [PMID:11682051, RESID:AA0378]
comment: See also the biological process term 'peptidyl-tyrosine dehydrogenation ; GO:0018251'.
synonym: "biosynthesis of protein-protein cross-link via 2-imino-glutamic acid 5-imidazolinone glycine" EXACT []
synonym: "biosynthetic process of protein-protein cross-link via 2-imino-glutamic acid 5-imidazolinone glycine" EXACT []
xref: RESID:AA0378
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018200 ! peptidyl-glutamic acid modification
is_a: GO:0018201 ! peptidyl-glycine modification
is_a: GO:0018298 ! protein-chromophore linkage

[Term]
id: GO:0051359
name: peptide cross-linking via 2-imino-methionine 5-imidazolinone glycine
namespace: biological_process
def: "The formation of the fluorescent protein FP611 chromophore cross-link from the alpha-carboxyl carbon of residue n, a methionine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons. This modification is found in the GFP-like fluorescent chromoprotein from the sea anemone Entacmaea quadricolor." [PDB:1UIS, PDB:1XQM, PMID:10852900, PMID:12185250, PMID:12909624, PMID:15542608, RESID:AA0379]
comment: See also the biological process term 'peptidyl-tyrosine dehydrogenation ; GO:0018251'.
synonym: "biosynthesis of protein-protein cross-link via 2-imino-methionine 5-imidazolinone glycine" EXACT []
synonym: "biosynthetic process of protein-protein cross-link via 2-imino-methionine 5-imidazolinone glycine" EXACT []
xref: RESID:AA0379
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018201 ! peptidyl-glycine modification
is_a: GO:0018206 ! peptidyl-methionine modification
is_a: GO:0018298 ! protein-chromophore linkage

[Term]
id: GO:0051360
name: peptide cross-linking via L-asparagine 5-imidazolinone glycine
namespace: biological_process
def: "The formation of the fluorescent protein FP506 chromophore cross-link from the alpha-carboxyl carbon of residue n, an asparagine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons." [PMID:10504696, RESID:AA0380]
comment: See also the biological process term 'peptidyl-tyrosine dehydrogenation ; GO:0018251'.
synonym: "biosynthesis of protein-protein cross-link via L-asparagine 5-imidazolinone glycine" EXACT []
synonym: "biosynthetic process of protein-protein cross-link via L-asparagine 5-imidazolinone glycine" EXACT []
xref: RESID:AA0380
is_a: GO:0018196 ! peptidyl-asparagine modification
is_a: GO:0018253 ! peptide cross-linking via 5-imidazolinone glycine
is_a: GO:0018298 ! protein-chromophore linkage

[Term]
id: GO:0051361
name: peptide cross-linking via L-lysine 5-imidazolinone glycine
namespace: biological_process
def: "The formation of a fluorescent protein chromophore cross-link from the alpha-carboxyl carbon of residue n, a lysine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons." [PMID:10504696, RESID:AA0381]
comment: See also the biological process term 'peptidyl-tyrosine dehydrogenation ; GO:0018251'.
synonym: "biosynthesis of protein-protein cross-link via L-lysine 5-imidazolinone glycine" EXACT []
synonym: "biosynthetic process of protein-protein cross-link via L-lysine 5-imidazolinone glycine" EXACT []
xref: RESID:AA0381
is_a: GO:0018205 ! peptidyl-lysine modification
is_a: GO:0018253 ! peptide cross-linking via 5-imidazolinone glycine
is_a: GO:0018298 ! protein-chromophore linkage

[Term]
id: GO:0051362
name: peptide cross-linking via 2-tetrahydropyridinyl-5-imidazolinone glycine
namespace: biological_process
def: "The formation of a 2-tetrahydropyridinyl-5-imidazolinone protein chromophore cross-link from the alpha-carboxyl carbon of residue n, a lysine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons. In addition, the residue N lysine undergoes cyclization. The alpha-amino nitrogen is replaced by the epsilon-amino nitrogen, the peptide chain is broken, residue N-1 is released as an amide, and a double bond is formed between the alpha-carbon and the nitrogen so that a tetrahydropyridine ring results. This modification is found in the GFP-like fluorescent chromoprotein FP538 from the sea anemone Zoanthus species." [PDB:1XAE, PMID:10504696, PMID:15628861, RESID:AA0382]
comment: See also the biological process term 'peptidyl-tyrosine dehydrogenation ; GO:0018251'.
synonym: "biosynthesis of protein-protein cross-link via 2-tetrahydropyridinyl-5-imidazolinone glycine" EXACT []
synonym: "biosynthetic process of protein-protein cross-link via 2-tetrahydropyridinyl-5-imidazolinone glycine" EXACT []
xref: RESID:AA0382
is_a: GO:0018205 ! peptidyl-lysine modification
is_a: GO:0018253 ! peptide cross-linking via 5-imidazolinone glycine
is_a: GO:0018298 ! protein-chromophore linkage

[Term]
id: GO:0051363
name: peptidoglycan-protein cross-linking via L-alanyl-pentaglycyl-murein
namespace: biological_process
def: "The process of linking a protein to peptidoglycan via a carboxy terminal alanine carboxyl group through a pentaglycyl peptide to the lysine or diaminopimelic acid of the peptidoglycan." [PMID:8163519, PMID:9086265, RESID:AA0383]
comment: Note that this modification may be unique to the species Finegoldia (Peptostreptococcus) magnus.
subset: gosubset_prok
xref: RESID:AA0383
is_a: GO:0018104 ! peptidoglycan-protein cross-linking
is_a: GO:0018194 ! peptidyl-alanine modification

[Term]
id: GO:0051364
name: N-terminal peptidyl-proline N-formylation
namespace: biological_process
def: "The formylation of the N-terminal proline of proteins to form the derivative N-formylproline." [PMID:12051774, PMID:5464655, RESID:AA0384]
xref: RESID:AA0384
is_a: GO:0018004 ! N-terminal protein formylation
is_a: GO:0018208 ! peptidyl-proline modification

[Term]
id: GO:0051365
name: cellular response to potassium ion starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of potassium ions." [GOC:sm]
synonym: "cellular response to K+ ion deprivation" EXACT []
synonym: "cellular response to K+ ion starvation" EXACT []
synonym: "cellular response to potassium ion deprivation" EXACT []
synonym: "cellular response to potassium starvation" EXACT []
is_a: GO:0009267 ! cellular response to starvation

[Term]
id: GO:0051366
name: protein decanoylation
namespace: biological_process
def: "The modification of a protein amino acid by formation of an ester or amide with decanoic acid." [GOC:jsg]
synonym: "protein amino acid decanoylation" EXACT [GOC:bf]
is_a: GO:0006497 ! protein lipidation
is_a: GO:0043543 ! protein acylation

[Term]
id: GO:0051367
name: peptidyl-serine decanoylation
namespace: biological_process
def: "The decanoylation of peptidyl-serine to form peptidyl-O3-decanoyl-L-serine, typical of the protein ghrelin." [GOC:jsg, PMID:12630926, RESID:AA0385]
xref: RESID:AA0385
is_a: GO:0018209 ! peptidyl-serine modification
is_a: GO:0051366 ! protein decanoylation

[Term]
id: GO:0051368
name: peptidyl-threonine octanoylation
namespace: biological_process
def: "The octanoylation of peptidyl-threonine to form peptidyl-O3-octanoyl-L-threonine, typical of the protein ghrelin." [GOC:jsg, PMID:11546772, RESID:AA0387]
xref: RESID:AA0386
is_a: GO:0018190 ! protein octanoylation
is_a: GO:0018210 ! peptidyl-threonine modification

[Term]
id: GO:0051369
name: peptidyl-threonine decanoylation
namespace: biological_process
def: "The decanoylation of peptidyl-threonine to form peptidyl-O3-decanoyl-L-threonine, typical of the protein ghrelin." [GOC:jsg, PMID:11546772, RESID:AA0387]
xref: RESID:AA0387
is_a: GO:0018210 ! peptidyl-threonine modification
is_a: GO:0051366 ! protein decanoylation

[Term]
id: GO:0051370
name: obsolete ZASP binding
namespace: molecular_function
def: "OBSOLETE. Interacting selectively and non-covalently with Z-band alternatively spliced PDZ motif protein (ZASP). ZASP is a Z-band protein specifically expressed in heart and skeletal muscle. This protein contains N-terminal PDZ domain and C-terminal LIM domain." [PMID:10427098, PMID:11699871]
comment: This term was made obsolete because it represents binding to an individual protein.
synonym: "Z-band alternatively spliced PDZ-motif protein binding" EXACT []
synonym: "ZASP binding" EXACT []
is_obsolete: true
replaced_by: GO:0008092

[Term]
id: GO:0051371
name: muscle alpha-actinin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with muscle isoforms of actinin. Muscle alpha-actinin isoforms are found in skeletal and cardiac muscle and are localized to the Z-disc." [PMID:10984498, PMID:11699871, PMID:15014165]
synonym: "alpha-actinin 2 binding" NARROW []
synonym: "alpha-actinin 3 binding" NARROW []
is_a: GO:0051393 ! alpha-actinin binding

[Term]
id: GO:0051373
name: FATZ binding
namespace: molecular_function
alt_id: GO:0051374
alt_id: GO:0051375
alt_id: GO:0051376
def: "Interacting selectively and non-covalently with a member of the FATZ family of proteins, filamin-, actinin-, and telethonin-binding proteins of the Z-disc of striated muscle. FATZ proteins are located in the Z-disc of the sarcomere and are involved in a complex network of interactions with other Z-band components." [PMID:10984498, PMID:11699871]
synonym: "calsarcin 1 binding" EXACT []
synonym: "calsarcin 2 binding" EXACT []
synonym: "calsarcin 3 binding" EXACT []
synonym: "calsarcin binding" EXACT []
synonym: "FATZ 1 binding" EXACT []
synonym: "FATZ 2 binding" EXACT []
synonym: "FATZ 3 binding" EXACT []
synonym: "filamin-, actinin- and telethonin-binding protein of the Z-disc of striated muscle" EXACT []
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0051377
name: mannose-ethanolamine phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of ethanolamine phosphate to a mannose residue in the GPI lipid precursor." [PMID:15632136]
synonym: "addition of ethanolamine phosphate to mannose of GPI precursor" EXACT []
synonym: "ethanolamine phosphate transferase activity" BROAD []
synonym: "EtN-P transferase activity" EXACT []
synonym: "phosphoethanolamine transferase activity" BROAD []
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0051378
name: serotonin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:ai]
synonym: "5-hydroxytryptamine binding" EXACT []
is_a: GO:0043176 ! amine binding
is_a: GO:0070405 ! ammonium ion binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding

[Term]
id: GO:0051379
name: epinephrine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine." [GOC:ai]
synonym: "adrenaline binding" EXACT []
is_a: GO:1901338 ! catecholamine binding

[Term]
id: GO:0051380
name: norepinephrine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with norepinephrine, (3,4-dihydroxyphenyl-2-aminoethanol), a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine." [GOC:ai]
synonym: "noradrenaline binding" EXACT []
is_a: GO:1901338 ! catecholamine binding

[Term]
id: GO:0051381
name: histamine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:ai]
is_a: GO:0070405 ! ammonium ion binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding

[Term]
id: GO:0051382
name: kinetochore assembly
namespace: biological_process
alt_id: GO:0000069
def: "The aggregation, arrangement and bonding together of a set of components to form the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:ai]
synonym: "centromere and kinetochore complex maturation" NARROW []
synonym: "centromere/kinetochore complex maturation" NARROW []
synonym: "chromosome-kinetochore attachment" NARROW [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "kinetochore biogenesis" EXACT []
synonym: "kinetochore biosynthesis" EXACT []
synonym: "kinetochore formation" RELATED []
is_a: GO:0022402 ! cell cycle process
is_a: GO:0043623 ! cellular protein complex assembly
is_a: GO:0051383 ! kinetochore organization
is_a: GO:0070925 ! organelle assembly
is_a: GO:1902589 ! single-organism organelle organization
relationship: part_of GO:0034508 ! centromere complex assembly

[Term]
id: GO:0051383
name: kinetochore organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
synonym: "kinetochore organisation" EXACT [GOC:curators]
synonym: "kinetochore organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0051276 ! chromosome organization
is_a: GO:0071822 ! protein complex subunit organization

[Term]
id: GO:0051384
name: response to glucocorticoid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects." [CHEBI:24261, GOC:ai, PMID:9884123]
synonym: "response to glucocorticoid stimulus" EXACT [GOC:dos]
is_a: GO:0031960 ! response to corticosteroid

[Term]
id: GO:0051385
name: response to mineralocorticoid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mineralocorticoid stimulus. Mineralocorticoids are hormonal C21 corticosteroids synthesized from cholesterol and characterized by their similarity to aldosterone. Mineralocorticoids act primarily on water and electrolyte balance." [GOC:ai, PMID:9884123]
synonym: "response to mineralocorticoid stimulus" EXACT [GOC:dos]
is_a: GO:0031960 ! response to corticosteroid

[Term]
id: GO:0051386
name: regulation of neurotrophin TRK receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the neurotrophin TRK receptor signaling pathway." [GOC:ai]
synonym: "regulation of nerve growth factor receptor signaling pathway" RELATED [GOC:jc]
synonym: "regulation of nerve growth factor receptor signalling pathway" EXACT []
synonym: "regulation of NGF receptor signaling pathway" EXACT []
synonym: "regulation of NGF receptor signalling pathway" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0090287 ! regulation of cellular response to growth factor stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048011 ! neurotrophin TRK receptor signaling pathway
relationship: regulates GO:0048011 ! neurotrophin TRK receptor signaling pathway

[Term]
id: GO:0051387
name: negative regulation of neurotrophin TRK receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the neurotrophin TRK receptor signaling pathway." [GOC:ai]
synonym: "down regulation of nerve growth factor receptor signaling pathway" EXACT []
synonym: "down-regulation of nerve growth factor receptor signaling pathway" EXACT []
synonym: "downregulation of nerve growth factor receptor signaling pathway" EXACT []
synonym: "inhibition of nerve growth factor receptor signaling pathway" NARROW []
synonym: "negative regulation of nerve growth factor receptor signaling pathway" RELATED [GOC:jc]
synonym: "negative regulation of nerve growth factor receptor signalling pathway" EXACT []
synonym: "negative regulation of NGF receptor signaling pathway" EXACT []
synonym: "negative regulation of NGF receptor signalling pathway" EXACT []
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0051386 ! regulation of neurotrophin TRK receptor signaling pathway
is_a: GO:0090288 ! negative regulation of cellular response to growth factor stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048011 ! neurotrophin TRK receptor signaling pathway
relationship: negatively_regulates GO:0048011 ! neurotrophin TRK receptor signaling pathway

[Term]
id: GO:0051388
name: positive regulation of neurotrophin TRK receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the neurotrophin TRK receptor signaling pathway." [GOC:ai]
synonym: "activation of nerve growth factor receptor signaling pathway" NARROW []
synonym: "positive regulation of nerve growth factor receptor signaling pathway" RELATED [GOC:jc]
synonym: "positive regulation of nerve growth factor receptor signalling pathway" EXACT []
synonym: "positive regulation of NGF receptor signaling pathway" EXACT []
synonym: "positive regulation of NGF receptor signalling pathway" EXACT []
synonym: "stimulation of nerve growth factor receptor signaling pathway" NARROW []
synonym: "up regulation of nerve growth factor receptor signaling pathway" EXACT []
synonym: "up-regulation of nerve growth factor receptor signaling pathway" EXACT []
synonym: "upregulation of nerve growth factor receptor signaling pathway" EXACT []
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0051386 ! regulation of neurotrophin TRK receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048011 ! neurotrophin TRK receptor signaling pathway
relationship: positively_regulates GO:0048011 ! neurotrophin TRK receptor signaling pathway

[Term]
id: GO:0051389
name: inactivation of MAPKK activity
namespace: biological_process
def: "Any process that terminates the activity of the active enzyme MAP kinase kinase (MAPKK)." [GOC:ai]
synonym: "inactivation of MAP kinase kinase activity" EXACT []
synonym: "termination of MAP kinase kinase activity" EXACT []
synonym: "termination of MAPKK activity" EXACT []
is_a: GO:0006469 ! negative regulation of protein kinase activity
is_a: GO:0043405 ! regulation of MAP kinase activity
is_a: GO:0043409 ! negative regulation of MAPK cascade
relationship: negatively_regulates GO:0004708 ! MAP kinase kinase activity

[Term]
id: GO:0051390
name: inactivation of MAPKKK activity
namespace: biological_process
def: "Any process that terminates the activity of the active enzyme MAP kinase kinase kinase (MAPKKK)." [GOC:ai]
synonym: "inactivation of MAP kinase kinase kinase activity" EXACT []
synonym: "termination of MAP kinase kinase kinase activity" EXACT []
synonym: "termination of MAPKKK activity" EXACT []
is_a: GO:0043405 ! regulation of MAP kinase activity
is_a: GO:0043409 ! negative regulation of MAPK cascade
is_a: GO:0071901 ! negative regulation of protein serine/threonine kinase activity
relationship: negatively_regulates GO:0004709 ! MAP kinase kinase kinase activity

[Term]
id: GO:0051391
name: tRNA acetylation
namespace: biological_process
def: "The modification of tRNA structure by addition of an acetyl group to tRNA. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai]
is_a: GO:0006400 ! tRNA modification
is_a: GO:1990884 ! RNA acetylation

[Term]
id: GO:0051392
name: tRNA N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + cytidine = CoA + N4-acetylcytidine. The cytidine is within the polynucleotide chain of a tRNA." [PMID:15037780]
synonym: "tRNA cytidine N-acetyltransferase activity" EXACT []
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0051393
name: alpha-actinin binding
namespace: molecular_function
alt_id: GO:0051372
def: "Interacting selectively and non-covalently with alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats." [PMID:10984498, PMID:11699871, PMID:15014165]
synonym: "alpha-actinin 1 binding" NARROW []
synonym: "alpha-actinin 4 binding" NARROW []
synonym: "nonmuscle alpha-actinin binding" NARROW []
is_a: GO:0042805 ! actinin binding

[Term]
id: GO:0051394
name: regulation of nerve growth factor receptor activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the activity of the nerve growth factor (NGF) receptor." [GOC:ai]
synonym: "regulation of NGF receptor activity" EXACT []
is_a: GO:0010469 ! regulation of receptor activity
is_a: GO:0090287 ! regulation of cellular response to growth factor stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010465 ! nerve growth factor receptor activity
relationship: regulates GO:0010465 ! nerve growth factor receptor activity

[Term]
id: GO:0051395
name: negative regulation of nerve growth factor receptor activity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the nerve growth factor (NGF) receptor." [GOC:ai]
synonym: "down regulation of nerve growth factor receptor activity" EXACT []
synonym: "down-regulation of nerve growth factor receptor activity" EXACT []
synonym: "downregulation of nerve growth factor receptor activity" EXACT []
synonym: "inhibition of nerve growth factor receptor activity" NARROW []
synonym: "negative regulation of NGF receptor activity" EXACT []
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0051394 ! regulation of nerve growth factor receptor activity
is_a: GO:0090288 ! negative regulation of cellular response to growth factor stimulus
is_a: GO:2000272 ! negative regulation of receptor activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010465 ! nerve growth factor receptor activity
relationship: negatively_regulates GO:0010465 ! nerve growth factor receptor activity

[Term]
id: GO:0051396
name: positive regulation of nerve growth factor receptor activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the activity of the nerve growth factor (NGF) receptor." [GOC:ai]
synonym: "activation of nerve growth factor receptor activity" NARROW []
synonym: "positive regulation of NGF receptor activity" EXACT []
synonym: "stimulation of nerve growth factor receptor activity" NARROW []
synonym: "up regulation of nerve growth factor receptor activity" EXACT []
synonym: "up-regulation of nerve growth factor receptor activity" EXACT []
synonym: "upregulation of nerve growth factor receptor activity" EXACT []
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0051394 ! regulation of nerve growth factor receptor activity
is_a: GO:2000273 ! positive regulation of receptor activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010465 ! nerve growth factor receptor activity
relationship: positively_regulates GO:0010465 ! nerve growth factor receptor activity

[Term]
id: GO:0051397
name: obsolete N-terminal basic amino acid aminopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of basic amino acid residues at the N-terminal of an oligopeptide or polypeptide chain." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "N-terminal basic amino acid aminopeptidase activity" EXACT []
is_obsolete: true
replaced_by: GO:0004177

[Term]
id: GO:0051398
name: obsolete N-terminal lysine aminopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of a lysine residue from the N-terminal of an oligopeptide or polypeptide chain." [GOC:ai, PMID:12799365]
comment: This term was made obsolete because it represents a gene product.
synonym: "lysine aminopeptidase activity" BROAD []
synonym: "lysyl aminopeptidase activity" BROAD []
synonym: "N-terminal lysine aminopeptidase activity" EXACT []
is_obsolete: true
replaced_by: GO:0004177

[Term]
id: GO:0051399
name: obsolete N-terminal arginine aminopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of an arginine residue from the N-terminal of an oligopeptide or polypeptide chain." [GOC:ai, PMID:12799365]
comment: This term was made obsolete because it represents a gene product.
synonym: "arginine aminopeptidase activity" BROAD []
synonym: "argininyl aminopeptidase activity" BROAD []
synonym: "N-terminal arginine aminopeptidase activity" EXACT []
is_obsolete: true
replaced_by: GO:0004177

[Term]
id: GO:0051400
name: BH domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the Bcl-2 homology (BH) domain of a protein. Bcl-2-related proteins share homology in one to four conserved regions designated the Bcl-2 homology (BH) domains BH1, BH2, BH3 and BH4. These domains contribute at multiple levels to the function of these proteins in cell death and survival. Anti-apoptotic members of the Bcl-2 family have four BH domains (BH1-BH4). Pro-apoptotic members have fewer BH domains." [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409]
subset: goslim_chembl
synonym: "Bcl-2 homology domain binding" EXACT []
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0051401
name: CH domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the calponin homology domain of a protein, a domain of 100 residues that occurs in signaling and cytoskeletal proteins." [PMID:11911887, Prosite:PDOC50021]
synonym: "calponin homology domain binding" EXACT []
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0051402
name: neuron apoptotic process
namespace: biological_process
def: "Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." [CL:0000540, GOC:mtg_apoptosis, MeSH:A.08.663]
synonym: "apoptosis of neuronal cells" EXACT []
synonym: "apoptosis of neurons" EXACT []
synonym: "neuron apoptosis" NARROW []
synonym: "neuron programmed cell death by apoptosis" EXACT []
synonym: "neuronal cell apoptosis" EXACT []
synonym: "neuronal cell programmed cell death by apoptosis" EXACT []
synonym: "programmed cell death of neuronal cells by apoptosis" EXACT []
synonym: "programmed cell death of neurons by apoptosis" EXACT []
synonym: "programmed cell death, neuronal cells" EXACT []
synonym: "programmed cell death, neurons" EXACT []
is_a: GO:0006915 ! apoptotic process
is_a: GO:0070997 ! neuron death

[Term]
id: GO:0051403
name: stress-activated MAPK cascade
namespace: biological_process
def: "A series of molecular signals in which a stress-activated MAP kinase cascade relays one or more of the signals; MAP kinase cascades involve at least three protein kinase activities and culminate in the phosphorylation and activation of a MAP kinase." [GOC:ai, PMID:15936270]
synonym: "MAPK11 cascade" NARROW [GOC:add]
synonym: "MAPK12 cascade" NARROW [GOC:add]
synonym: "MAPK13 cascade" NARROW [GOC:add]
synonym: "MAPK14 cascade" NARROW [GOC:add]
synonym: "p38 cascade" NARROW [GOC:add]
synonym: "p38 MAPK signaling" NARROW []
synonym: "p38 MAPK signalling" NARROW []
synonym: "SAPK cascade" BROAD [GOC:add]
synonym: "stress-activated MAPK signaling pathway" EXACT []
synonym: "stress-activated MAPK signalling pathway" EXACT []
synonym: "stress-activated MAPKKK cascade" EXACT []
synonym: "stress-activated MAPKKK signaling pathway" EXACT []
synonym: "stress-activated MAPKKK signalling pathway" EXACT []
xref: Reactome:REACT_103389 "MAP kinase activation in TLR cascade, Dictyostelium discoideum"
xref: Reactome:REACT_104595 "MAP kinase activation in TLR cascade, Taeniopygia guttata"
xref: Reactome:REACT_104796 "MAP kinase activation in TLR cascade, Mus musculus"
xref: Reactome:REACT_105109 "MAP kinase activation in TLR cascade, Danio rerio"
xref: Reactome:REACT_109896 "MAP kinase activation in TLR cascade, Canis familiaris"
xref: Reactome:REACT_21308 "MAP kinase activation in TLR cascade, Homo sapiens"
xref: Reactome:REACT_30115 "MAP kinase activation in TLR cascade, Rattus norvegicus"
xref: Reactome:REACT_32136 "MAP kinase activation in TLR cascade, Caenorhabditis elegans"
xref: Reactome:REACT_34622 "MAP kinase activation in TLR cascade, Oryza sativa"
xref: Reactome:REACT_79433 "MAP kinase activation in TLR cascade, Xenopus tropicalis"
xref: Reactome:REACT_82500 "MAP kinase activation in TLR cascade, Drosophila melanogaster"
xref: Reactome:REACT_85645 "MAP kinase activation in TLR cascade, Saccharomyces cerevisiae"
xref: Reactome:REACT_85847 "MAP kinase activation in TLR cascade, Bos taurus"
xref: Reactome:REACT_89123 "MAP kinase activation in TLR cascade, Sus scrofa"
xref: Reactome:REACT_95758 "MAP kinase activation in TLR cascade, Gallus gallus"
xref: Reactome:REACT_95991 "MAP kinase activation in TLR cascade, Schizosaccharomyces pombe"
xref: Reactome:REACT_98311 "MAP kinase activation in TLR cascade, Arabidopsis thaliana"
is_a: GO:0000165 ! MAPK cascade
is_a: GO:0031098 ! stress-activated protein kinase signaling cascade

[Term]
id: GO:0051404
name: obsolete clostripain activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of Arg-Xaa bonds." [EC:3.4.22.8]
comment: This term was made obsolete because it represents a gene product.
synonym: "alpha-clostridipain" RELATED [EC:3.4.22.8]
synonym: "clostridiopeptidase B activity" EXACT []
synonym: "Clostridium histolyticum proteinase B" RELATED [EC:3.4.22.8]
synonym: "clostripain activity" EXACT []
xref: EC:3.4.22.8
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0051405
name: obsolete microbial collagenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the digestion of native collagen in the triple helical region at Xaa-Gly bonds." [EC:3.4.24.3]
comment: This term was made obsolete because it represents a gene product.
synonym: "Achromobacter iophagus collagenase" RELATED [EC:3.4.24.3]
synonym: "aspergillopeptidase C" RELATED [EC:3.4.24.3]
synonym: "azocollase activity" EXACT [EC:3.4.24.3]
synonym: "clostridiopeptidase A activity" EXACT []
synonym: "clostridiopeptidase I" RELATED [EC:3.4.24.3]
synonym: "clostridiopeptidase II" RELATED [EC:3.4.24.3]
synonym: "Clostridium histolyticum collagenase activity" NARROW [EC:3.4.24.3]
synonym: "Clostridium histolyticum proteinase A" RELATED [EC:3.4.24.3]
synonym: "collagen peptidase activity" EXACT [EC:3.4.24.3]
synonym: "collagen protease activity" EXACT [EC:3.4.24.3]
synonym: "collagenase 1 activity" EXACT []
synonym: "collagenase A activity" EXACT []
synonym: "collagenase I activity" EXACT [EC:3.4.24.3]
synonym: "collagenase MMP-1" RELATED [EC:3.4.24.3]
synonym: "kollaza" RELATED [EC:3.4.24.3]
synonym: "matirx metalloproteinase-18" RELATED [EC:3.4.24.3]
synonym: "matrix metalloproteinase-1" RELATED [EC:3.4.24.3]
synonym: "matrix metalloproteinase-8" RELATED [EC:3.4.24.3]
synonym: "metallocollagenase activity" EXACT [EC:3.4.24.3]
synonym: "metalloproteinase-1" RELATED [EC:3.4.24.3]
synonym: "microbial collagenase activity" EXACT []
synonym: "nucleolysin" RELATED [EC:3.4.24.3]
synonym: "soycollagestin" RELATED [EC:3.4.24.3]
xref: EC:3.4.24.3
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0051407
name: glycerone phosphate:inorganic phosphate antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycerone phosphate(out) + phosphate(in) = glycerone phosphate(in) + phosphate(out)." [GOC:ai]
synonym: "dihydroxyacetone-phosphate:inorganic phosphate antiporter activity" EXACT []
is_a: GO:0005315 ! inorganic phosphate transmembrane transporter activity
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015315 ! organophosphate:inorganic phosphate antiporter activity
is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity
is_a: GO:1901505 ! carbohydrate derivative transporter activity

[Term]
id: GO:0051408
name: glyceraldehyde 3-phosphate:inorganic phosphate antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glyceraldehyde 3-phosphate(out) + phosphate(in) = glyceraldehyde 3-phosphate(in) + phosphate(out)." [GOC:ai]
is_a: GO:0005315 ! inorganic phosphate transmembrane transporter activity
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015315 ! organophosphate:inorganic phosphate antiporter activity
is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity
is_a: GO:1901505 ! carbohydrate derivative transporter activity

[Term]
id: GO:0051409
name: response to nitrosative stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions." [PMID:15925705]
is_a: GO:0006950 ! response to stress

[Term]
id: GO:0051410
name: detoxification of nitrogen compound
namespace: biological_process
def: "Any process that reduces or removes the toxicity of nitrogenous compounds which are dangerous or toxic. This includes the aerobic conversion of toxic compounds to harmless substances." [GOC:ai]
synonym: "detoxification of nitrogenous compound" EXACT []
synonym: "nitric oxide (NO) detoxification" NARROW []
is_a: GO:0006807 ! nitrogen compound metabolic process
is_a: GO:0098754 ! detoxification
relationship: part_of GO:1901698 ! response to nitrogen compound

[Term]
id: GO:0051411
name: obsolete ALP binding
namespace: molecular_function
def: "OBSOLETE. Interacting selectively and non-covalently wih ALP, actinin-associated LIM protein of the Z band. ALP is a PDZ/LIM domain protein found in the Z band." [PMID:11699871]
comment: This term was made obsolete because it represents binding to an individual protein.
synonym: "actinin-associated LIM protein binding" EXACT []
synonym: "ALP binding" EXACT []
is_obsolete: true
replaced_by: GO:0008092

[Term]
id: GO:0051412
name: response to corticosterone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosterone stimulus. Corticosterone is a 21 carbon steroid hormone of the corticosteroid type, produced in the cortex of the adrenal glands. In many species, corticosterone is the principal glucocorticoid, involved in regulation of fuel metabolism, immune reactions, and stress responses." [PMID:15240347]
synonym: "response to corticosterone stimulus" EXACT [GOC:dos]
is_a: GO:0051384 ! response to glucocorticoid
is_a: GO:0051385 ! response to mineralocorticoid
is_a: GO:0097305 ! response to alcohol
is_a: GO:1901654 ! response to ketone

[Term]
id: GO:0051413
name: response to cortisone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisone stimulus. Cortisone is a natural glucocorticoid steroid hormone that is metabolically convertible to cortisol. Cortisone is synthesized from cholesterol in the cortex of the adrenal gland under the stimulation of adrenocorticotropin hormone (ACTH). The main physiological effect of cortisone is on carbohydrate metabolism; it can stimulate increased glucose release from the liver, increased liver glycogen synthesis, and decreased utilization of glucose by the tissues." [ISBN:0721662544, PMID:11276391]
synonym: "response to cortisone stimulus" EXACT [GOC:dos]
is_a: GO:0051384 ! response to glucocorticoid
is_a: GO:0097305 ! response to alcohol
is_a: GO:1901654 ! response to ketone

[Term]
id: GO:0051414
name: response to cortisol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisol stimulus. Cortisol is the major natural glucocorticoid synthesized in the zona fasciculata of the adrenal cortex; it affects the metabolism of glucose, protein, and fats and has appreciable mineralocorticoid activity. It also regulates the immune system and affects many other functions." [ISBN:0721662544, PMID:11276391]
synonym: "response to cortisol stimulus" EXACT [GOC:dos]
synonym: "response to hydrocortisone stimulus" EXACT []
is_a: GO:0051384 ! response to glucocorticoid
is_a: GO:0097305 ! response to alcohol
is_a: GO:1901654 ! response to ketone

[Term]
id: GO:0051415
name: interphase microtubule nucleation by interphase microtubule organizing center
namespace: biological_process
def: "The 'de novo' formation of a microtubule by the interphase microtubule organizing center during interphase, the stage of cell cycle between successive rounds of chromosome segregation." [GOC:ai]
synonym: "IMTOC-mediated microtubule nucleation during interphase" EXACT []
synonym: "interphase microtubule nucleation by interphase microtubule organising centre" EXACT []
synonym: "interphase microtubule organizing center-mediated microtubule nucleation during interphase" EXACT []
synonym: "microtubule nucleation during interphase by IMTOC" EXACT []
synonym: "microtubule nucleation during interphase by interphase microtubule organizing center" EXACT []
is_a: GO:0022402 ! cell cycle process
is_a: GO:0051418 ! microtubule nucleation by microtubule organizing center

[Term]
id: GO:0051416
name: obsolete myotilin binding
namespace: molecular_function
def: "OBSOLETE. Interacting selectively and non-covalently with myotilin, a structural component of the Z-discs in human skeletal and cardiac muscle. Its C-terminus contains two immunoglobulin-like domains and the unique N-terminal half has a serine-rich region, with numerous potential phosphorylation sites, and a stretch of hydrophobic amino acids. Myotilin forms homodimers and binds to alpha-actinin, F-actin, and filamin C." [PMID:11699871, PMID:15752755]
comment: This term was made obsolete because it represents binding to an individual protein.
synonym: "myotilin binding" EXACT []
is_obsolete: true
replaced_by: GO:0008092

[Term]
id: GO:0051417
name: microtubule nucleation by spindle pole body
namespace: biological_process
def: "The 'de novo' formation of a microtubule, mediated by the spindle pole body." [GOC:ai]
synonym: "microtubule nucleation by SPB" EXACT []
synonym: "SPB-mediated microtubule nucleation" EXACT []
synonym: "spindle pole body-mediated microtubule nucleation" EXACT []
is_a: GO:0051418 ! microtubule nucleation by microtubule organizing center

[Term]
id: GO:0051418
name: microtubule nucleation by microtubule organizing center
namespace: biological_process
def: "The 'de novo' formation of a microtubule, mediated by the microtubule organizing center." [GOC:ai]
synonym: "microtubule nucleation by microtubule organising centre" EXACT []
synonym: "microtubule nucleation by MTOC" EXACT []
synonym: "microtubule organizing center-mediated microtubule nucleation" EXACT []
synonym: "MTOC-mediated microtubule nucleation" EXACT []
is_a: GO:0007020 ! microtubule nucleation

[Term]
id: GO:0051419
name: obsolete nebulin binding
namespace: molecular_function
def: "OBSOLETE. Interacting selectively and non-covalently with nebulin, a large protein (approximately 800kD) that is anchored at the Z-disc by its C-terminal region and spans the length of the thin filament, ending at the edge of the H-zone." [PMID:11699871]
comment: This term was made obsolete because it represents binding to an individual protein.
synonym: "nebulin binding" EXACT []
is_obsolete: true
replaced_by: GO:0008092

[Term]
id: GO:0051420
name: obsolete nebulette binding
namespace: molecular_function
def: "OBSOLETE. Interacting selectively and non-covalently with nebulette, a 107 kDa protein associated with the I-Z-I complex of cardiac myofibrils. It shows a high degree of homology with skeletal muscle nebulin." [PMID:11699871]
comment: This term was made obsolete because it represents binding to an individual protein.
synonym: "nebulette binding" EXACT []
is_obsolete: true
replaced_by: GO:0008092

[Term]
id: GO:0051421
name: regulation of endo-1,4-beta-xylanase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endo-(1->4)-beta-xylanase activity, the catalysis of the endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans." [EC:3.2.1.8, GOC:ai]
synonym: "endo-1,4-beta-xylanase regulator" RELATED []
synonym: "xylanase regulator" RELATED []
is_a: GO:0051336 ! regulation of hydrolase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031176 ! endo-1,4-beta-xylanase activity
relationship: regulates GO:0031176 ! endo-1,4-beta-xylanase activity

[Term]
id: GO:0051422
name: negative regulation of endo-1,4-beta-xylanase activity
namespace: biological_process
def: "Any process that stops or reduces the rate of endo-(1->4)-beta-xylanase activity, the catalysis of the endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans." [EC:3.2.1.8, GOC:ai]
synonym: "down regulation of endo-1,4-beta-xylanase activity" EXACT []
synonym: "down-regulation of endo-1,4-beta-xylanase activity" EXACT []
synonym: "downregulation of endo-1,4-beta-xylanase activity" EXACT []
synonym: "endo-1,4-beta-xylanase inhibitor" RELATED []
synonym: "inhibition of endo-1,4-beta-xylanase activity" NARROW []
synonym: "xylanase inhibitor" RELATED []
is_a: GO:0051346 ! negative regulation of hydrolase activity
is_a: GO:0051421 ! regulation of endo-1,4-beta-xylanase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0031176 ! endo-1,4-beta-xylanase activity
relationship: negatively_regulates GO:0031176 ! endo-1,4-beta-xylanase activity

[Term]
id: GO:0051423
name: positive regulation of endo-1,4-beta-xylanase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endo-(1->4)-beta-xylanase activity, the catalysis of the endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans." [EC:3.2.1.8, GOC:ai]
synonym: "activation of endo-1,4-beta-xylanase activity" NARROW []
synonym: "endo-1,4-beta-xylanase activator" RELATED []
synonym: "stimulation of endo-1,4-beta-xylanase activity" NARROW []
synonym: "up regulation of endo-1,4-beta-xylanase activity" EXACT []
synonym: "up-regulation of endo-1,4-beta-xylanase activity" EXACT []
synonym: "upregulation of endo-1,4-beta-xylanase activity" EXACT []
synonym: "xylanase activator" RELATED []
is_a: GO:0051345 ! positive regulation of hydrolase activity
is_a: GO:0051421 ! regulation of endo-1,4-beta-xylanase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0031176 ! endo-1,4-beta-xylanase activity
relationship: positively_regulates GO:0031176 ! endo-1,4-beta-xylanase activity

[Term]
id: GO:0051424
name: corticotropin-releasing hormone binding
namespace: molecular_function
alt_id: GO:0017047
def: "Interacting selectively and non-covalently with corticotropin-releasing hormone, a polypeptide hormone involved in the stress response. It is released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland." [http://www.onelook.com]
synonym: "corticoliberin binding" EXACT []
synonym: "corticotropin-releasing factor binding" EXACT []
synonym: "CRF binding" EXACT [GOC:bf]
synonym: "CRH binding" EXACT []
is_a: GO:0017046 ! peptide hormone binding

[Term]
id: GO:0051425
name: PTB domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a phosphotyrosine-binding (PTB) domain of a protein." [Pfam:PF02174.5, PMID:15924411]
synonym: "phosphotyrosine-interacting domain binding" EXACT []
synonym: "PID binding" BROAD []
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0051427
name: hormone receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a receptor for hormones." [GOC:ai]
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0051428
name: peptide hormone receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a receptor for peptide hormones." [GOC:ai]
subset: goslim_chembl
synonym: "polypeptide hormone receptor binding" EXACT []
is_a: GO:0051427 ! hormone receptor binding

[Term]
id: GO:0051429
name: corticotropin-releasing hormone receptor binding
namespace: molecular_function
alt_id: GO:0031742
def: "Interacting selectively and non-covalently with a receptor for corticotropin-releasing hormone (CRH), a polypeptide hormone involved in the stress response. It is released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland." [GOC:ai]
synonym: "corticotropin releasing factor receptor binding" EXACT []
synonym: "corticotropin releasing factor receptor ligand" NARROW []
synonym: "corticotropin-releasing factor receptor binding" EXACT [GOC:bf]
synonym: "CRF receptor binding" EXACT [GOC:bf]
synonym: "CRH receptor binding" EXACT [GOC:bf]
synonym: "CRHR binding" EXACT [GOC:bf]
is_a: GO:0051428 ! peptide hormone receptor binding
is_a: GO:0071855 ! neuropeptide receptor binding

[Term]
id: GO:0051430
name: corticotropin-releasing hormone receptor 1 binding
namespace: molecular_function
alt_id: GO:0031743
def: "Interacting selectively and non-covalently with the corticotropin-releasing hormone receptor 1 (CRHR1). CRHR1 is the major subtype in the pituitary corticotroph, and mediates the stimulatory actions of corticotropin-releasing hormone on corticotropin hormone secretion. CRHR1 are also located in cortical areas of the brain, cerebellum and limbic system." [PMID:15134857]
synonym: "CRHR1 binding" EXACT []
synonym: "type 1 corticotropin releasing factor receptor binding" EXACT []
synonym: "type 1 corticotropin releasing factor receptor ligand" NARROW []
synonym: "type 1 corticotropin-releasing factor receptor binding" EXACT [GOC:bf]
is_a: GO:0051429 ! corticotropin-releasing hormone receptor binding

[Term]
id: GO:0051431
name: corticotropin-releasing hormone receptor 2 binding
namespace: molecular_function
alt_id: GO:0031744
def: "Interacting selectively and non-covalently with the corticotropin-releasing hormone receptor type 2 (CRHR2). The CRHR2 has several splice variants that are located in sub-cortical areas of the brain and in the periphery." [PMID:15134857]
synonym: "CRHR2 binding" EXACT []
synonym: "type 2 corticotropin releasing factor receptor binding" EXACT []
synonym: "type 2 corticotropin releasing factor receptor ligand" NARROW []
synonym: "type 2 corticotropin-releasing factor receptor binding" EXACT [GOC:bf]
is_a: GO:0051429 ! corticotropin-releasing hormone receptor binding

[Term]
id: GO:0051432
name: BH1 domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the BH1 domain of a protein of the Bcl-2 family. Proteins that act as inhibitors of apoptosis harbour at least three BH domains: BH1, BH2 and BH3; the BH1 and BH2 domains are found in all death antagonists of the Bcl-2 family but only in one class of death agonists." [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409, Prosite:PS01080]
is_a: GO:0051400 ! BH domain binding

[Term]
id: GO:0051433
name: BH2 domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the BH2 domain of a protein of the Bcl-2 family. Proteins that act as inhibitors of apoptosis harbour at least three BH domains: BH1, BH2 and BH3; the BH1 and BH2 domains are found in all death antagonists of the Bcl-2 family but only in one class of death agonists." [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409, Prosite:PS01258]
is_a: GO:0051400 ! BH domain binding

[Term]
id: GO:0051434
name: BH3 domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the BH3 domain of a protein of the Bcl-2 family. The BH3 domain is a potent death domain and has an important role in protein-protein interactions and in cell death." [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409, Prosite:PS01259]
subset: goslim_chembl
is_a: GO:0051400 ! BH domain binding
is_a: GO:0070513 ! death domain binding

[Term]
id: GO:0051435
name: BH4 domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the BH4 domain of a protein of the Bcl-2 family. All anti-apoptotic proteins contain BH1 and BH2 domains; some also contain an additional N-terminal BH4 domain, which is almost never seen in pro-apoptotic proteins. Loss of the BH4 domain can diminish or abrogate anti-apoptotic function or even impart outright death-promoting properties to the protein." [InterPro:IPR003093, PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409, Prosite:PS01260, Prosite:PS50063]
is_a: GO:0051400 ! BH domain binding

[Term]
id: GO:0051436
name: negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin ligase activity that contributes to the mitotic cell cycle." [GOC:ai, GOC:tb]
synonym: "anaphase promoting complex inhibition during mitotic cell cycle" NARROW []
synonym: "anaphase-promoting complex inhibition during mitotic cell cycle" NARROW []
synonym: "APC inhibition during mitotic cell cycle" NARROW []
synonym: "down regulation of ubiquitin ligase activity during mitotic cell cycle" RELATED []
synonym: "down-regulation of ubiquitin ligase activity during mitotic cell cycle" RELATED []
synonym: "downregulation of ubiquitin ligase activity during mitotic cell cycle" RELATED []
synonym: "inhibition of ubiquitin ligase activity during mitotic cell cycle" NARROW []
synonym: "mitotic anaphase promoting complex inhibition" NARROW []
synonym: "mitotic anaphase promoting complex inhibitor" NARROW []
synonym: "mitotic anaphase-promoting complex inhibition" NARROW []
synonym: "mitotic anaphase-promoting complex inhibitor" NARROW []
synonym: "mitotic APC inhibition" NARROW []
synonym: "mitotic APC inhibitor" NARROW []
synonym: "mitotic SCF complex inhibitor" NARROW []
synonym: "mitotic ubiquitin ligase inhibitor" NARROW []
synonym: "negative regulation of ubiquitin ligase activity during mitotic cell cycle" RELATED [GOC:tb]
synonym: "negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle" RELATED [GOC:dph, GOC:tb]
xref: Reactome:REACT_100142 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Mus musculus"
xref: Reactome:REACT_100445 "Dissociation of phospho-Cdh1 from the APC/C complex, Drosophila melanogaster"
xref: Reactome:REACT_101151 "Dissociation of phospho-Cdh1 from the APC/C complex, Gallus gallus"
xref: Reactome:REACT_101227 "Association of Emi1 with Cdh1, Sus scrofa"
xref: Reactome:REACT_101353 "Autodegradation of Cdh1 by Cdh1:APC/C, Rattus norvegicus"
xref: Reactome:REACT_101600 "Autodegradation of Cdh1 by Cdh1:APC/C, Oryza sativa"
xref: Reactome:REACT_101893 "Association of Emi1 with Cdh1, Taeniopygia guttata"
xref: Reactome:REACT_1041 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, Homo sapiens"
xref: Reactome:REACT_107016 "Association of Emi1 with Cdc20, Sus scrofa"
xref: Reactome:REACT_107407 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, Canis familiaris"
xref: Reactome:REACT_108334 "Association of Emi1 with Cdh1, Gallus gallus"
xref: Reactome:REACT_108949 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, Gallus gallus"
xref: Reactome:REACT_109419 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Drosophila melanogaster"
xref: Reactome:REACT_109619 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, Taeniopygia guttata"
xref: Reactome:REACT_110332 "Autodegradation of Cdh1 by Cdh1:APC/C, Mus musculus"
xref: Reactome:REACT_110505 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Mus musculus"
xref: Reactome:REACT_110936 "Autodegradation of Cdh1 by Cdh1:APC/C, Xenopus tropicalis"
xref: Reactome:REACT_110945 "Association of Emi1 with Cdc20, Mus musculus"
xref: Reactome:REACT_113042 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Saccharomyces cerevisiae"
xref: Reactome:REACT_113195 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, Arabidopsis thaliana"
xref: Reactome:REACT_113808 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Schizosaccharomyces pombe"
xref: Reactome:REACT_114563 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, Oryza sativa"
xref: Reactome:REACT_28043 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Rattus norvegicus"
xref: Reactome:REACT_28963 "Association of Emi1 with Cdh1, Xenopus tropicalis"
xref: Reactome:REACT_29737 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Bos taurus"
xref: Reactome:REACT_30026 "Dissociation of phospho-Cdh1 from the APC/C complex, Arabidopsis thaliana"
xref: Reactome:REACT_30516 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, Drosophila melanogaster"
xref: Reactome:REACT_30857 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Canis familiaris"
xref: Reactome:REACT_30946 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Taeniopygia guttata"
xref: Reactome:REACT_31067 "Autodegradation of Cdh1 by Cdh1:APC/C, Taeniopygia guttata"
xref: Reactome:REACT_31098 "Association of Emi1 with Cdh1, Bos taurus"
xref: Reactome:REACT_31143 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Arabidopsis thaliana"
xref: Reactome:REACT_31936 "Autodegradation of Cdh1 by Cdh1:APC/C, Gallus gallus"
xref: Reactome:REACT_33157 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, Mus musculus"
xref: Reactome:REACT_33255 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Oryza sativa"
xref: Reactome:REACT_33337 "Dissociation of phospho-Cdh1 from the APC/C complex, Danio rerio"
xref: Reactome:REACT_33422 "Association of Emi1 with Cdc20, Danio rerio"
xref: Reactome:REACT_6721 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Homo sapiens"
xref: Reactome:REACT_6745 "Association of Emi1 with Cdc20, Homo sapiens"
xref: Reactome:REACT_6773 "Association of Emi1 with Cdh1, Homo sapiens"
xref: Reactome:REACT_6785 "Autodegradation of Cdh1 by Cdh1:APC/C, Homo sapiens"
xref: Reactome:REACT_6811 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Homo sapiens"
xref: Reactome:REACT_6845 "Dissociation of phospho-Cdh1 from the APC/C complex, Homo sapiens"
xref: Reactome:REACT_78275 "Association of Emi1 with Cdc20, Bos taurus"
xref: Reactome:REACT_81772 "Autodegradation of Cdh1 by Cdh1:APC/C, Bos taurus"
xref: Reactome:REACT_81857 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, Bos taurus"
xref: Reactome:REACT_81918 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Drosophila melanogaster"
xref: Reactome:REACT_81946 "Autodegradation of Cdh1 by Cdh1:APC/C, Drosophila melanogaster"
xref: Reactome:REACT_82578 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Danio rerio"
xref: Reactome:REACT_83000 "Association of Emi1 with Cdc20, Xenopus tropicalis"
xref: Reactome:REACT_83890 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, Xenopus tropicalis"
xref: Reactome:REACT_84020 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Xenopus tropicalis"
xref: Reactome:REACT_84061 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Rattus norvegicus"
xref: Reactome:REACT_84462 "Dissociation of phospho-Cdh1 from the APC/C complex, Taeniopygia guttata"
xref: Reactome:REACT_85360 "Association of Emi1 with Cdh1, Danio rerio"
xref: Reactome:REACT_85707 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Canis familiaris"
xref: Reactome:REACT_85766 "Dissociation of phospho-Cdh1 from the APC/C complex, Oryza sativa"
xref: Reactome:REACT_86349 "Association of Emi1 with Cdh1, Canis familiaris"
xref: Reactome:REACT_88500 "Association of Emi1 with Cdh1, Mus musculus"
xref: Reactome:REACT_88651 "Autodegradation of Cdh1 by Cdh1:APC/C, Canis familiaris"
xref: Reactome:REACT_88799 "Dissociation of phospho-Cdh1 from the APC/C complex, Mus musculus"
xref: Reactome:REACT_90365 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, Sus scrofa"
xref: Reactome:REACT_90596 "Dissociation of phospho-Cdh1 from the APC/C complex, Canis familiaris"
xref: Reactome:REACT_91269 "Association of Emi1 with Cdh1, Rattus norvegicus"
xref: Reactome:REACT_91998 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, Dictyostelium discoideum"
xref: Reactome:REACT_92690 "Dissociation of phospho-Cdh1 from the APC/C complex, Rattus norvegicus"
xref: Reactome:REACT_93689 "Autodegradation of Cdh1 by Cdh1:APC/C, Danio rerio"
xref: Reactome:REACT_93696 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Danio rerio"
xref: Reactome:REACT_94003 "Association of Emi1 with Cdc20, Gallus gallus"
xref: Reactome:REACT_94092 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Xenopus tropicalis"
xref: Reactome:REACT_95146 "Dissociation of phospho-Cdh1 from the APC/C complex, Xenopus tropicalis"
xref: Reactome:REACT_96413 "Association of Emi1 with Cdc20, Canis familiaris"
xref: Reactome:REACT_96435 "Association of Emi1 with Cdc20, Taeniopygia guttata"
xref: Reactome:REACT_96450 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, Rattus norvegicus"
xref: Reactome:REACT_98168 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, Danio rerio"
xref: Reactome:REACT_98605 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Bos taurus"
xref: Reactome:REACT_99005 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Gallus gallus"
xref: Reactome:REACT_99200 "Dissociation of phospho-Cdh1 from the APC/C complex, Bos taurus"
xref: Reactome:REACT_99420 "Association of Emi1 with Cdc20, Rattus norvegicus"
is_a: GO:0051439 ! regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
is_a: GO:0051444 ! negative regulation of ubiquitin-protein transferase activity
intersection_of: GO:0051444 ! negative regulation of ubiquitin-protein transferase activity
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0051437
name: positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of ubiquitin ligase activity that contributes to the regulation of the mitotic cell cycle phase transition." [GOC:ai, GOC:tb]
synonym: "activation of ubiquitin ligase activity during mitotic cell cycle" NARROW []
synonym: "mitotic SCF complex activator" NARROW []
synonym: "mitotic ubiquitin ligase activator" NARROW []
synonym: "positive regulation of ubiquitin ligase activity during mitotic cell cycle" RELATED [GOC:tb]
synonym: "positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle" RELATED [GOC:dph, GOC:tb]
synonym: "stimulation of ubiquitin ligase activity during mitotic cell cycle" NARROW []
synonym: "up regulation of ubiquitin ligase activity during mitotic cell cycle" RELATED []
synonym: "up-regulation of ubiquitin ligase activity during mitotic cell cycle" RELATED []
synonym: "upregulation of ubiquitin ligase activity during mitotic cell cycle" RELATED []
xref: Reactome:REACT_101805 "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1, Danio rerio"
xref: Reactome:REACT_101941 "Phosphorylation of the APC/C, Taeniopygia guttata"
xref: Reactome:REACT_101955 "Phosphorylation of the APC/C, Danio rerio"
xref: Reactome:REACT_105145 "Phosphorylation of the APC/C, Rattus norvegicus"
xref: Reactome:REACT_106123 "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1, Mus musculus"
xref: Reactome:REACT_106884 "SCF-beta-TrCP mediated degradation of Emi1, Drosophila melanogaster"
xref: Reactome:REACT_107186 "SCF-beta-TrCP mediated degradation of Emi1, Mus musculus"
xref: Reactome:REACT_110529 "SCF-beta-TrCP mediated degradation of Emi1, Canis familiaris"
xref: Reactome:REACT_112598 "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1, Bos taurus"
xref: Reactome:REACT_113510 "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1, Arabidopsis thaliana"
xref: Reactome:REACT_29165 "SCF-beta-TrCP mediated degradation of Emi1, Taeniopygia guttata"
xref: Reactome:REACT_32501 "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1, Canis familiaris"
xref: Reactome:REACT_33604 "Phosphorylation of the APC/C, Canis familiaris"
xref: Reactome:REACT_34546 "Phosphorylation of the APC/C, Drosophila melanogaster"
xref: Reactome:REACT_6733 "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1, Homo sapiens"
xref: Reactome:REACT_6821 "SCF-beta-TrCP mediated degradation of Emi1, Homo sapiens"
xref: Reactome:REACT_6904 "Phosphorylation of the APC/C, Homo sapiens"
xref: Reactome:REACT_77684 "SCF-beta-TrCP mediated degradation of Emi1, Xenopus tropicalis"
xref: Reactome:REACT_77765 "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1, Rattus norvegicus"
xref: Reactome:REACT_78093 "Phosphorylation of the APC/C, Xenopus tropicalis"
xref: Reactome:REACT_80081 "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1, Taeniopygia guttata"
xref: Reactome:REACT_82338 "SCF-beta-TrCP mediated degradation of Emi1, Rattus norvegicus"
xref: Reactome:REACT_84583 "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1, Gallus gallus"
xref: Reactome:REACT_86267 "Phosphorylation of the APC/C, Mus musculus"
xref: Reactome:REACT_90212 "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1, Xenopus tropicalis"
xref: Reactome:REACT_91329 "Phosphorylation of the APC/C, Bos taurus"
xref: Reactome:REACT_91690 "SCF-beta-TrCP mediated degradation of Emi1, Bos taurus"
xref: Reactome:REACT_92784 "Phosphorylation of the APC/C, Gallus gallus"
xref: Reactome:REACT_97729 "SCF-beta-TrCP mediated degradation of Emi1, Gallus gallus"
is_a: GO:0051443 ! positive regulation of ubiquitin-protein transferase activity
is_a: GO:2000060 ! positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
intersection_of: GO:0051443 ! positive regulation of ubiquitin-protein transferase activity
intersection_of: part_of GO:1901990 ! regulation of mitotic cell cycle phase transition
relationship: part_of GO:1901990 ! regulation of mitotic cell cycle phase transition

[Term]
id: GO:0051438
name: regulation of ubiquitin-protein transferase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ubiquitin transferase activity." [GOC:ai, GOC:tb]
synonym: "anaphase-promoting complex regulator" NARROW []
synonym: "APC regulator" NARROW []
synonym: "regulation of ubiquitin transferase activity" EXACT [GOC:tb]
synonym: "SCF complex regulator" NARROW []
synonym: "ubiquitin transferase regulator" RELATED []
synonym: "ubiquitin-protein transferase regulator" RELATED []
is_a: GO:0031396 ! regulation of protein ubiquitination
is_a: GO:0051338 ! regulation of transferase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004842 ! ubiquitin-protein transferase activity
relationship: regulates GO:0004842 ! ubiquitin-protein transferase activity

[Term]
id: GO:0051439
name: regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
namespace: biological_process
def: "A cell cycle process that modulates the frequency, rate or extent of ubiquitin ligase activity that contributes to the mitotic cell cycle." [GOC:ai]
synonym: "mitotic anaphase-promoting complex regulator" NARROW []
synonym: "mitotic APC regulator" NARROW []
synonym: "mitotic SCF complex regulator" NARROW []
synonym: "mitotic ubiquitin ligase regulator" RELATED []
synonym: "mitotic ubiquitin-protein ligase regulator" RELATED []
synonym: "regulation of ubiquitin ligase activity during mitotic cell cycle" RELATED [GOC:tb]
synonym: "regulation of ubiquitin-protein ligase activity during mitotic cell cycle" RELATED [GOC:dph, GOC:tb]
xref: Reactome:REACT_101451 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, Gallus gallus"
xref: Reactome:REACT_102310 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, Xenopus tropicalis"
xref: Reactome:REACT_105248 "Regulation of APC/C activators between G1/S and early anaphase, Oryza sativa"
xref: Reactome:REACT_106660 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, Arabidopsis thaliana"
xref: Reactome:REACT_106902 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, Oryza sativa"
xref: Reactome:REACT_109987 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, Taeniopygia guttata"
xref: Reactome:REACT_114183 "Regulation of APC/C activators between G1/S and early anaphase, Saccharomyces cerevisiae"
xref: Reactome:REACT_28152 "Regulation of APC/C activators between G1/S and early anaphase, Drosophila melanogaster"
xref: Reactome:REACT_29664 "Regulation of APC/C activators between G1/S and early anaphase, Dictyostelium discoideum"
xref: Reactome:REACT_32993 "Regulation of APC/C activators between G1/S and early anaphase, Bos taurus"
xref: Reactome:REACT_6837 "Regulation of APC/C activators between G1/S and early anaphase, Homo sapiens"
xref: Reactome:REACT_6867 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, Homo sapiens"
xref: Reactome:REACT_79510 "Regulation of APC/C activators between G1/S and early anaphase, Schizosaccharomyces pombe"
xref: Reactome:REACT_79637 "Regulation of APC/C activators between G1/S and early anaphase, Rattus norvegicus"
xref: Reactome:REACT_81889 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, Schizosaccharomyces pombe"
xref: Reactome:REACT_82881 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, Canis familiaris"
xref: Reactome:REACT_84326 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, Danio rerio"
xref: Reactome:REACT_85472 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, Sus scrofa"
xref: Reactome:REACT_86217 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, Rattus norvegicus"
xref: Reactome:REACT_86939 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, Mus musculus"
xref: Reactome:REACT_87214 "Regulation of APC/C activators between G1/S and early anaphase, Mus musculus"
xref: Reactome:REACT_90721 "Regulation of APC/C activators between G1/S and early anaphase, Danio rerio"
xref: Reactome:REACT_90808 "Regulation of APC/C activators between G1/S and early anaphase, Canis familiaris"
xref: Reactome:REACT_93090 "Regulation of APC/C activators between G1/S and early anaphase, Xenopus tropicalis"
xref: Reactome:REACT_93672 "Regulation of APC/C activators between G1/S and early anaphase, Gallus gallus"
xref: Reactome:REACT_95909 "Regulation of APC/C activators between G1/S and early anaphase, Taeniopygia guttata"
xref: Reactome:REACT_96088 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, Drosophila melanogaster"
xref: Reactome:REACT_97346 "Regulation of APC/C activators between G1/S and early anaphase, Arabidopsis thaliana"
xref: Reactome:REACT_97869 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, Bos taurus"
xref: Reactome:REACT_97959 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, Saccharomyces cerevisiae"
xref: Reactome:REACT_99134 "Regulation of APC/C activators between G1/S and early anaphase, Sus scrofa"
is_a: GO:0051438 ! regulation of ubiquitin-protein transferase activity
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0051438 ! regulation of ubiquitin-protein transferase activity
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0051440
name: regulation of ubiquitin-protein ligase activity involved in meiotic cell cycle
namespace: biological_process
def: "A cell cycle process that modulates the frequency, rate or extent of ubiquitin ligase activity during the meiotic cell cycle." [GOC:ai, GOC:tb]
synonym: "meiotic anaphase-promoting complex regulator" NARROW []
synonym: "meiotic APC regulator" NARROW []
synonym: "meiotic SCF complex regulator" NARROW []
synonym: "meiotic ubiquitin ligase regulator" RELATED []
synonym: "meiotic ubiquitin-protein ligase regulator" RELATED []
synonym: "regulation of ubiquitin ligase activity during meiotic cell cycle" RELATED [GOC:tb]
synonym: "regulation of ubiquitin-protein ligase activity during meiotic cell cycle" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051438 ! regulation of ubiquitin-protein transferase activity
is_a: GO:1903046 ! meiotic cell cycle process
intersection_of: GO:0051438 ! regulation of ubiquitin-protein transferase activity
intersection_of: part_of GO:0051321 ! meiotic cell cycle
relationship: part_of GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0051441
name: positive regulation of ubiquitin-protein ligase activity involved in meiotic cell cycle
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of ubiquitin ligase activity during the meiotic cell cycle." [GOC:ai, GOC:tb]
synonym: "activation of ubiquitin ligase activity during meiotic cell cycle" NARROW []
synonym: "meiotic SCF complex activator" NARROW []
synonym: "meiotic ubiquitin ligase activator" NARROW []
synonym: "positive regulation of ubiquitin ligase activity during meiotic cell cycle" RELATED [GOC:tb]
synonym: "positive regulation of ubiquitin-protein ligase activity during meiotic cell cycle" RELATED [GOC:dph, GOC:tb]
synonym: "stimulation of ubiquitin ligase activity during meiotic cell cycle" NARROW []
synonym: "up regulation of ubiquitin ligase activity during meiotic cell cycle" RELATED []
synonym: "up-regulation of ubiquitin ligase activity during meiotic cell cycle" RELATED []
synonym: "upregulation of ubiquitin ligase activity during meiotic cell cycle" RELATED []
is_a: GO:0051440 ! regulation of ubiquitin-protein ligase activity involved in meiotic cell cycle
is_a: GO:0051443 ! positive regulation of ubiquitin-protein transferase activity
intersection_of: GO:0051443 ! positive regulation of ubiquitin-protein transferase activity
intersection_of: part_of GO:0051321 ! meiotic cell cycle
relationship: part_of GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0051442
name: negative regulation of ubiquitin-protein ligase activity involved in meiotic cell cycle
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin ligase activity during the meiotic cell cycle." [GOC:ai, GOC:tb]
synonym: "anaphase promoting complex inhibition during meiotic cell cycle" NARROW []
synonym: "anaphase-promoting complex inhibition during meiotic cell cycle" NARROW []
synonym: "APC inhibition during meiotic cell cycle" NARROW []
synonym: "down regulation of ubiquitin ligase activity during meiotic cell cycle" RELATED []
synonym: "down-regulation of ubiquitin ligase activity during meiotic cell cycle" RELATED []
synonym: "downregulation of ubiquitin ligase activity during meiotic cell cycle" RELATED []
synonym: "inhibition of ubiquitin ligase activity during meiotic cell cycle" NARROW []
synonym: "meiotic anaphase promoting complex inhibition" NARROW []
synonym: "meiotic anaphase promoting complex inhibitor" NARROW []
synonym: "meiotic anaphase-promoting complex inhibition" NARROW []
synonym: "meiotic anaphase-promoting complex inhibitor" NARROW []
synonym: "meiotic APC inhibition" NARROW []
synonym: "meiotic APC inhibitor" NARROW []
synonym: "meiotic SCF complex inhibitor" NARROW []
synonym: "meiotic ubiquitin ligase inhibitor" NARROW []
synonym: "negative regulation of ubiquitin ligase activity during meiotic cell cycle" RELATED [GOC:tb]
is_a: GO:0051440 ! regulation of ubiquitin-protein ligase activity involved in meiotic cell cycle
is_a: GO:0051444 ! negative regulation of ubiquitin-protein transferase activity
intersection_of: GO:0051444 ! negative regulation of ubiquitin-protein transferase activity
intersection_of: part_of GO:0051321 ! meiotic cell cycle
relationship: part_of GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0051443
name: positive regulation of ubiquitin-protein transferase activity
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of ubiquitin transferase activity." [GOC:ai, GOC:tb]
synonym: "activation of ubiquitin transferase activity" NARROW []
synonym: "anaphase promoting complex activator" NARROW []
synonym: "anaphase-promoting complex activator" NARROW []
synonym: "APC activation" NARROW []
synonym: "APC activator" NARROW []
synonym: "positive regulation of ubiquitin transferase activity" EXACT [GOC:tb]
synonym: "SCF complex activator" NARROW []
synonym: "stimulation of ubiquitin transferase activity" NARROW []
synonym: "ubiquitin transferase activator" NARROW []
synonym: "up regulation of ubiquitin ligase activity" EXACT []
synonym: "up-regulation of ubiquitin transferase activity" EXACT []
synonym: "upregulation of ubiquitin transferase activity" EXACT []
is_a: GO:0031398 ! positive regulation of protein ubiquitination
is_a: GO:0051347 ! positive regulation of transferase activity
is_a: GO:0051351 ! positive regulation of ligase activity
is_a: GO:0051438 ! regulation of ubiquitin-protein transferase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004842 ! ubiquitin-protein transferase activity
relationship: positively_regulates GO:0004842 ! ubiquitin-protein transferase activity

[Term]
id: GO:0051444
name: negative regulation of ubiquitin-protein transferase activity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin transferase activity." [GOC:ai, GOC:tb]
synonym: "anaphase promoting complex inhibition" NARROW []
synonym: "anaphase promoting complex inhibitor" NARROW []
synonym: "anaphase-promoting complex inhibition" NARROW []
synonym: "anaphase-promoting complex inhibitor" NARROW []
synonym: "APC inhibition" NARROW []
synonym: "APC inhibitor" NARROW []
synonym: "down regulation of ubiquitin transferase activity" EXACT []
synonym: "down-regulation of ubiquitin transferase activity" EXACT []
synonym: "downregulation of ubiquitin transferase activity" EXACT []
synonym: "inhibition of ubiquitin transferase activity" NARROW []
synonym: "negative regulation of ubiquitin transferase activity" EXACT [GOC:tb]
synonym: "SCF complex inhibitor" NARROW []
synonym: "ubiquitin transferase inhibitor" NARROW []
is_a: GO:0031397 ! negative regulation of protein ubiquitination
is_a: GO:0051348 ! negative regulation of transferase activity
is_a: GO:0051352 ! negative regulation of ligase activity
is_a: GO:0051438 ! regulation of ubiquitin-protein transferase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004842 ! ubiquitin-protein transferase activity
relationship: negatively_regulates GO:0004842 ! ubiquitin-protein transferase activity

[Term]
id: GO:0051445
name: regulation of meiotic cell cycle
namespace: biological_process
def: "Any process that modulates the rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb]
synonym: "meiotic cell cycle modulation" EXACT []
synonym: "meiotic cell cycle regulation" EXACT []
synonym: "meiotic cell cycle regulator" RELATED []
synonym: "modulation of meiotic cell cycle progression" EXACT []
synonym: "regulation of meiotic cell cycle progression" EXACT []
synonym: "regulation of progression through meiotic cell cycle" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051726 ! regulation of cell cycle
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051321 ! meiotic cell cycle
relationship: regulates GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0051446
name: positive regulation of meiotic cell cycle
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb]
synonym: "activation of progression through meiotic cell cycle" NARROW []
synonym: "positive regulation of meiotic cell cycle progression" EXACT []
synonym: "positive regulation of progression through meiotic cell cycle" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of progression through meiotic cell cycle" NARROW []
synonym: "up regulation of progression through meiotic cell cycle" EXACT []
synonym: "up-regulation of progression through meiotic cell cycle" EXACT []
synonym: "upregulation of progression through meiotic cell cycle" EXACT []
is_a: GO:0045787 ! positive regulation of cell cycle
is_a: GO:0051445 ! regulation of meiotic cell cycle
is_a: GO:2000243 ! positive regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051321 ! meiotic cell cycle
relationship: positively_regulates GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0051447
name: negative regulation of meiotic cell cycle
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb]
synonym: "down regulation of progression through meiotic cell cycle" EXACT []
synonym: "down-regulation of progression through meiotic cell cycle" EXACT []
synonym: "downregulation of progression through meiotic cell cycle" EXACT []
synonym: "inhibition of progression through meiotic cell cycle" NARROW []
synonym: "negative regulation of meiotic cell cycle progression" EXACT []
synonym: "negative regulation of progression through meiotic cell cycle" EXACT [GOC:dph, GOC:tb]
is_a: GO:0045786 ! negative regulation of cell cycle
is_a: GO:0051445 ! regulation of meiotic cell cycle
is_a: GO:2000242 ! negative regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051321 ! meiotic cell cycle
relationship: negatively_regulates GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0051448
name: gonadotropin-releasing hormone binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with gonadotropin-releasing hormone (GnRH), a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus." [GOC:pr, PMID:1984190]
synonym: "GnRH binding" EXACT []
synonym: "gonadotrophin releasing hormone binding" EXACT []
is_a: GO:0017046 ! peptide hormone binding

[Term]
id: GO:0051449
name: thyrotropin-releasing hormone binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with thyrotropin-releasing hormone, a tripeptide hormone that stimulates the release of thyroid-stimulating hormone (TSH) and prolactin by the anterior pituitary and it is produced by the hypothalamus and travels across the median eminence to the pituitary via the pituitary portal system." [GOC:ai]
synonym: "thyrotropin releasing hormone binding" EXACT []
is_a: GO:0017046 ! peptide hormone binding

[Term]
id: GO:0051450
name: myoblast proliferation
namespace: biological_process
def: "The multiplication or reproduction of myoblasts, resulting in the expansion of a myoblast cell population. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ai, GOC:mtg_muscle]
is_a: GO:0008283 ! cell proliferation

[Term]
id: GO:0051451
name: myoblast migration
namespace: biological_process
def: "The orderly movement of a myoblast from one site to another, often during the development of a multicellular organism. A myoblast is a cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ai, GOC:mtg_muscle]
is_a: GO:0014812 ! muscle cell migration

[Term]
id: GO:0051452
name: intracellular pH reduction
namespace: biological_process
def: "Any process that reduces the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai]
synonym: "cell pH reduction" EXACT []
synonym: "cellular acidification" EXACT []
synonym: "intracellular acidification" RELATED []
synonym: "reduction of cellular pH" EXACT []
synonym: "reduction of pH in cell" EXACT []
is_a: GO:0045851 ! pH reduction
is_a: GO:0051453 ! regulation of intracellular pH

[Term]
id: GO:0051453
name: regulation of intracellular pH
namespace: biological_process
def: "Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]
synonym: "cell pH regulation" EXACT []
synonym: "cellular pH regulation" EXACT []
synonym: "pH regulation in cell" EXACT []
synonym: "regulation of cell pH" EXACT []
is_a: GO:0030641 ! regulation of cellular pH

[Term]
id: GO:0051454
name: intracellular pH elevation
namespace: biological_process
def: "Any process that increases the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai]
synonym: "cell pH elevation" EXACT []
synonym: "cellular alkalinization" EXACT []
synonym: "elevation of cellular pH" EXACT []
synonym: "intracellular alkalinization" EXACT []
synonym: "pH elevation in cell" EXACT []
is_a: GO:0045852 ! pH elevation
is_a: GO:0051453 ! regulation of intracellular pH

[Term]
id: GO:0051455
name: attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation
namespace: biological_process
def: "The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex during meiosis I. During meiosis I sister kinetochores are lying next to each other facing the same spindle pole and monopolar attachment of the chromatid to the spindle occurs." [GOC:ai, GOC:clt, GOC:dph, GOC:tb]
comment: Note that the synonym 'monopolar attachment' refers to the normal attachment of sister chromosomes to the spindle in meiosis I, and not to the aberrant attachment of sister kinetochores to a single pole in mitosis.
synonym: "attachment of spindle microtubules to kinetochore during meiosis I" RELATED [GOC:dph, GOC:tb]
synonym: "attachment of spindle microtubules to kinetochore involved in meiosis I" EXACT [GOC:dph, GOC:tb]
synonym: "monopolar attachment" EXACT []
synonym: "sister kinetochore mono-orientation" EXACT []
is_a: GO:0051316 ! attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation
is_a: GO:0090172 ! microtubule cytoskeleton organization involved in homologous chromosome segregation
intersection_of: GO:0008608 ! attachment of spindle microtubules to kinetochore
intersection_of: part_of GO:0045143 ! homologous chromosome segregation
relationship: part_of GO:0045143 ! homologous chromosome segregation

[Term]
id: GO:0051456
name: attachment of spindle microtubules to kinetochore involved in meiotic sister chromatid segregation
namespace: biological_process
def: "The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex during meiosis II. During meiosis II sister kinetochores are situated facing opposite spindle poles and bipolar attachment of the sister chromosomes to the spindle occurs." [GOC:ai, GOC:clt, GOC:dph, GOC:tb]
synonym: "attachment of spindle microtubules to kinetochore during meiosis II" RELATED [GOC:dph, GOC:tb]
synonym: "attachment of spindle microtubules to kinetochore involved in meiosis II" RELATED [GOC:dph, GOC:tb]
synonym: "meiotic bipolar attachment" RELATED [GOC:vw]
is_a: GO:0051316 ! attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation
intersection_of: GO:0008608 ! attachment of spindle microtubules to kinetochore
intersection_of: part_of GO:0045144 ! meiotic sister chromatid segregation
relationship: part_of GO:0045144 ! meiotic sister chromatid segregation

[Term]
id: GO:0051457
name: maintenance of protein location in nucleus
namespace: biological_process
def: "Any process in which a protein is maintained in the nucleus and prevented from moving elsewhere. These include sequestration within the nucleus, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the nucleus." [GOC:ai]
synonym: "maintenance of nuclear protein localization" EXACT []
synonym: "maintenance of protein localization in nucleus" RELATED [GOC:dph, GOC:tb]
synonym: "maintenance of protein location in cell nucleus" EXACT []
synonym: "nuclear protein retention" NARROW []
synonym: "nuclear protein sequestering" NARROW []
synonym: "nuclear protein sequestration" NARROW []
synonym: "protein retention in nucleus" NARROW []
synonym: "protein sequestration in nucleus" NARROW []
synonym: "protein storage in nucleus" NARROW []
synonym: "protein-nuclear retention" NARROW []
synonym: "sequestration of protein in nucleus" NARROW []
synonym: "storage of protein in nucleus" NARROW []
is_a: GO:0072595 ! maintenance of protein localization in organelle
intersection_of: GO:0045185 ! maintenance of protein location
intersection_of: occurs_in GO:0005634 ! nucleus
relationship: occurs_in GO:0005634 ! nucleus
relationship: part_of GO:0034504 ! protein localization to nucleus

[Term]
id: GO:0051458
name: corticotropin secretion
namespace: biological_process
def: "The regulated release of corticotropin by a cell. Corticotropin hormone is a polypeptide hormone synthesized and secreted from corticotropes in the anterior lobe of the pituitary gland in response to corticotropin-releasing hormone (CRH) released by the hypothalamus." [CHEBI:3892, GOC:cjm, PMID:11027914]
synonym: "ACTH secretion" EXACT []
synonym: "adrenocorticotropic hormone secretion" EXACT []
synonym: "adrenocorticotropin secretion" RELATED [GOC:dph, GOC:tb]
synonym: "adrenotropic hormone secretion" EXACT []
synonym: "adrenotropin secretion" EXACT []
synonym: "corticotropic hormone secretion" EXACT []
is_a: GO:0030072 ! peptide hormone secretion
is_a: GO:0060986 ! endocrine hormone secretion

[Term]
id: GO:0051459
name: regulation of corticotropin secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of corticotropic hormone from a cell." [GOC:ai, GOC:dph]
synonym: "regulation of ACTH secretion" EXACT []
synonym: "regulation of adrenocorticotropic hormone secretion" EXACT [GOC:dph]
synonym: "regulation of adrenocorticotropin secretion" EXACT []
synonym: "regulation of adrenotropin hormone secretion" EXACT []
synonym: "regulation of adrenotropin secretion" EXACT []
synonym: "regulation of corticotropic hormone secretion" EXACT []
is_a: GO:0044060 ! regulation of endocrine process
is_a: GO:0090276 ! regulation of peptide hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051458 ! corticotropin secretion
relationship: regulates GO:0051458 ! corticotropin secretion

[Term]
id: GO:0051460
name: negative regulation of corticotropin secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of corticotropic hormone from a cell." [GOC:ai]
synonym: "down regulation of adrenocorticotropin secretion" EXACT []
synonym: "down-regulation of adrenocorticotropin secretion" EXACT []
synonym: "downregulation of adrenocorticotropin secretion" EXACT []
synonym: "inhibition of adrenocorticotropin secretion" NARROW []
synonym: "negative regulation of ACTH secretion" EXACT []
synonym: "negative regulation of adrenocorticotropic hormone secretion" EXACT []
synonym: "negative regulation of adrenocorticotropin secretion" EXACT []
synonym: "negative regulation of adrenotropic hormone secretion" EXACT []
synonym: "negative regulation of adrenotropin secretion" EXACT []
synonym: "negative regulation of corticotropic hormone secretion" EXACT []
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0051459 ! regulation of corticotropin secretion
is_a: GO:0090278 ! negative regulation of peptide hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051458 ! corticotropin secretion
relationship: negatively_regulates GO:0051458 ! corticotropin secretion

[Term]
id: GO:0051461
name: positive regulation of corticotropin secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of corticotropin hormone from a cell." [GOC:ai]
synonym: "activation of adrenocorticotropin secretion" NARROW []
synonym: "positive regulation of ACTH secretion" EXACT []
synonym: "positive regulation of adrenocorticotropic hormone secretion" EXACT []
synonym: "positive regulation of adrenocorticotropin secretion" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of adrenotropic hormone secretion" EXACT []
synonym: "positive regulation of adrenotropin secretion" EXACT []
synonym: "positive regulation of corticotropic hormone secretion" EXACT []
synonym: "stimulation of adrenocorticotropin secretion" NARROW []
synonym: "up regulation of adrenocorticotropin secretion" EXACT []
synonym: "up-regulation of adrenocorticotropin secretion" EXACT []
synonym: "upregulation of adrenocorticotropin secretion" EXACT []
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0051459 ! regulation of corticotropin secretion
is_a: GO:0090277 ! positive regulation of peptide hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051458 ! corticotropin secretion
relationship: positively_regulates GO:0051458 ! corticotropin secretion

[Term]
id: GO:0051462
name: regulation of cortisol secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of cortisol from a cell." [GOC:ai]
is_a: GO:2000849 ! regulation of glucocorticoid secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043400 ! cortisol secretion
relationship: regulates GO:0043400 ! cortisol secretion

[Term]
id: GO:0051463
name: negative regulation of cortisol secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of cortisol from a cell." [GOC:ai]
synonym: "down regulation of cortisol secretion" EXACT []
synonym: "down-regulation of cortisol secretion" EXACT []
synonym: "downregulation of cortisol secretion" EXACT []
synonym: "inhibition of cortisol secretion" NARROW []
is_a: GO:0051462 ! regulation of cortisol secretion
is_a: GO:2000850 ! negative regulation of glucocorticoid secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043400 ! cortisol secretion
relationship: negatively_regulates GO:0043400 ! cortisol secretion

[Term]
id: GO:0051464
name: positive regulation of cortisol secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of cortisol from a cell." [GOC:ai]
synonym: "activation of cortisol secretion" NARROW []
synonym: "stimulation of cortisol secretion" NARROW []
synonym: "up regulation of cortisol secretion" EXACT []
synonym: "up-regulation of cortisol secretion" EXACT []
synonym: "upregulation of cortisol secretion" EXACT []
is_a: GO:0051462 ! regulation of cortisol secretion
is_a: GO:2000851 ! positive regulation of glucocorticoid secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043400 ! cortisol secretion
relationship: positively_regulates GO:0043400 ! cortisol secretion

[Term]
id: GO:0051465
name: negative regulation of corticotropin-releasing hormone secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of corticotropin-releasing hormone from a cell." [GOC:ai]
synonym: "down regulation of corticotropin-releasing hormone secretion" EXACT []
synonym: "down-regulation of corticotropin-releasing hormone secretion" EXACT []
synonym: "downregulation of corticotropin-releasing hormone secretion" EXACT []
synonym: "inhibition of corticotropin-releasing hormone secretion" NARROW []
synonym: "negative regulation of corticotropin-releasing factor secretion" EXACT []
synonym: "negative regulation of CRF secretion" EXACT []
synonym: "negative regulation of CRH secretion" EXACT []
is_a: GO:0043397 ! regulation of corticotropin-releasing hormone secretion
is_a: GO:0090278 ! negative regulation of peptide hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043396 ! corticotropin-releasing hormone secretion
relationship: negatively_regulates GO:0043396 ! corticotropin-releasing hormone secretion

[Term]
id: GO:0051466
name: positive regulation of corticotropin-releasing hormone secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of corticotropin-releasing hormone from a cell." [GOC:ai]
synonym: "activation of corticotropin-releasing hormone secretion" NARROW []
synonym: "positive regulation of corticotropin-releasing factor secretion" EXACT []
synonym: "positive regulation of CRF secretion" EXACT []
synonym: "positive regulation of CRH secretion" EXACT []
synonym: "stimulation of corticotropin-releasing hormone secretion" NARROW []
synonym: "up regulation of corticotropin-releasing hormone secretion" EXACT []
synonym: "up-regulation of corticotropin-releasing hormone secretion" EXACT []
synonym: "upregulation of corticotropin-releasing hormone secretion" EXACT []
is_a: GO:0043397 ! regulation of corticotropin-releasing hormone secretion
is_a: GO:0090277 ! positive regulation of peptide hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043396 ! corticotropin-releasing hormone secretion
relationship: positively_regulates GO:0043396 ! corticotropin-releasing hormone secretion

[Term]
id: GO:0051467
name: detection of steroid hormone stimulus
namespace: biological_process
def: "The series of events by which a steroid hormone stimulus is received by a cell and converted into a molecular signal." [GOC:ai]
is_a: GO:0009720 ! detection of hormone stimulus
is_a: GO:0048545 ! response to steroid hormone

[Term]
id: GO:0051468
name: detection of glucocorticoid hormone stimulus
namespace: biological_process
def: "The series of events by which a glucocorticoid hormone stimulus is received by a cell and converted into a molecular signal. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects." [GOC:ai]
is_a: GO:0051384 ! response to glucocorticoid
is_a: GO:0051467 ! detection of steroid hormone stimulus

[Term]
id: GO:0051469
name: vesicle fusion with vacuole
namespace: biological_process
alt_id: GO:0042146
def: "The joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the vacuole." [GOC:ai]
synonym: "heterotypic vacuole fusion (non-autophagic)" RELATED []
synonym: "heterotypic vacuole fusion, non-autophagic" RELATED []
is_a: GO:0006906 ! vesicle fusion
is_a: GO:0097576 ! vacuole fusion

[Term]
id: GO:0051470
name: ectoine transport
namespace: biological_process
def: "The directed movement of ectoine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid) is a tetrahydropyrimidine commonly synthesized by halophilic bacteria." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0071705 ! nitrogen compound transport

[Term]
id: GO:0051471
name: ectoine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of ectoine from one side of the membrane to the other. Ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid) is a tetrahydropyrimidine commonly synthesized by halophilic bacteria." [GOC:ai]
subset: gosubset_prok
xref: RHEA:32794
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
relationship: part_of GO:0051470 ! ectoine transport

[Term]
id: GO:0051472
name: glucosylglycerol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glucosylglycerol, alpha-D-glucopyranosyl-alpha-(1,2)-glycerol." [GOC:ai]
synonym: "glucosylglycerol metabolism" EXACT []
is_a: GO:0006073 ! cellular glucan metabolic process
is_a: GO:0019400 ! alditol metabolic process

[Term]
id: GO:0051473
name: glucosylglycerol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glucosylglycerol, alpha-D-glucopyranosyl-alpha-(1,2)-glycerol." [GOC:ai]
synonym: "glucosylglycerol anabolism" EXACT []
synonym: "glucosylglycerol biosynthesis" EXACT []
synonym: "glucosylglycerol formation" EXACT []
synonym: "glucosylglycerol synthesis" EXACT []
is_a: GO:0019401 ! alditol biosynthetic process
is_a: GO:0051472 ! glucosylglycerol metabolic process

[Term]
id: GO:0051474
name: glucosylglycerol transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a glucosylglycerol from one side of the membrane to the other. A glucosylglycerol is an alpha-D-glucopyranosyl-alpha-(1,2)-glycerol." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015144 ! carbohydrate transmembrane transporter activity
is_a: GO:0015166 ! polyol transmembrane transporter activity
relationship: part_of GO:0051475 ! glucosylglycerol transport

[Term]
id: GO:0051475
name: glucosylglycerol transport
namespace: biological_process
def: "The directed movement of glucosylglycerol, alpha-D-glucopyranosyl-alpha-(1,2)-glycerol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0008643 ! carbohydrate transport
is_a: GO:0015791 ! polyol transport

[Term]
id: GO:0051476
name: mannosylglycerate transport
namespace: biological_process
def: "The directed movement of mannosylglycerate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0008643 ! carbohydrate transport
is_a: GO:0046942 ! carboxylic acid transport
is_a: GO:1901656 ! glycoside transport

[Term]
id: GO:0051477
name: mannosylglycerate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a mannosylglycerate from one side of the membrane to the other." [GOC:ai, PMID:15034926]
is_a: GO:0015144 ! carbohydrate transmembrane transporter activity
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity
is_a: GO:1901505 ! carbohydrate derivative transporter activity
relationship: part_of GO:0051476 ! mannosylglycerate transport

[Term]
id: GO:0051478
name: mannosylglycerate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mannosylglycerate, a very common compatible solute in thermophilic and hyperthermophilic organisms." [GOC:ai, PMID:11562374]
synonym: "mannosylglycerate metabolism" EXACT []
is_a: GO:0016137 ! glycoside metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process
is_a: GO:0044262 ! cellular carbohydrate metabolic process
is_a: GO:0044723 ! single-organism carbohydrate metabolic process

[Term]
id: GO:0051479
name: mannosylglycerate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of mannosylglycerate, a very common compatible solute in thermophilic and hyperthermophilic organisms." [GOC:ai]
synonym: "mannosylglycerate anabolism" EXACT []
synonym: "mannosylglycerate biosynthesis" EXACT []
synonym: "mannosylglycerate formation" EXACT []
synonym: "mannosylglycerate synthesis" EXACT []
is_a: GO:0016138 ! glycoside biosynthetic process
is_a: GO:0034637 ! cellular carbohydrate biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
is_a: GO:0051478 ! mannosylglycerate metabolic process

[Term]
id: GO:0051480
name: regulation of cytosolic calcium ion concentration
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings." [GOC:ai, GOC:mah, GOC:rph]
synonym: "calcium ion homeostasis in cytoplasm" BROAD []
synonym: "calcium ion homeostasis in cytosol" EXACT []
synonym: "cytoplasmic calcium ion concentration regulation" BROAD []
synonym: "cytoplasmic calcium ion homeostasis" BROAD []
synonym: "cytosolic calcium ion concentration regulation" EXACT []
synonym: "regulation of calcium ion concentration in cytoplasm" BROAD []
synonym: "regulation of calcium ion concentration in cytosol" EXACT []
synonym: "regulation of cytoplasmic calcium ion concentration" BROAD []
synonym: "regulation of cytosolic calcium ion concentration" EXACT []
is_a: GO:0006874 ! cellular calcium ion homeostasis

[Term]
id: GO:0051481
name: negative regulation of cytosolic calcium ion concentration
namespace: biological_process
def: "Any process that decreases the concentration of calcium ions in the cytosol." [GOC:ai]
synonym: "cytoplasmic calcium ion concentration reduction" BROAD []
synonym: "cytosolic calcium ion concentration reduction" EXACT []
synonym: "reduction of calcium ion concentration in cytoplasm" BROAD []
synonym: "reduction of calcium ion concentration in cytosol" EXACT []
synonym: "reduction of cytoplasmic calcium ion concentration" BROAD []
synonym: "reduction of cytosolic calcium ion concentration" EXACT []
is_a: GO:0051480 ! regulation of cytosolic calcium ion concentration

[Term]
id: GO:0051482
name: positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
namespace: biological_process
def: "Any process that increases the concentration of calcium ions in the cytosol that occurs as part of a PLC-activating G-protein coupled receptor signaling pathway. G-protein-activated PLC hydrolyses phosphatidylinositol-bisphosphate (PIP2) to release diacylglycerol (DAG) and inositol trisphosphate (IP3). IP3 then binds to calcium release channels in the endoplasmic reticulum (ER) to trigger calcium ion release into the cytosol." [GOC:ai, GOC:signaling]
synonym: "elevation of calcium ion concentration in cytoplasm during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" BROAD []
synonym: "elevation of calcium ion concentration in cytosol during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" RELATED []
synonym: "elevation of cytoplasmic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" BROAD []
synonym: "elevation of cytoplasmic calcium ion concentration during G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" BROAD []
synonym: "elevation of cytosolic calcium ion concentration during G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" RELATED []
synonym: "elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger" EXACT [GOC:signaling]
synonym: "elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway" EXACT []
is_a: GO:0007204 ! positive regulation of cytosolic calcium ion concentration
intersection_of: GO:0007204 ! positive regulation of cytosolic calcium ion concentration
intersection_of: part_of GO:0007200 ! phospholipase C-activating G-protein coupled receptor signaling pathway
relationship: part_of GO:0007200 ! phospholipase C-activating G-protein coupled receptor signaling pathway

[Term]
id: GO:0051483
name: terpenoid biosynthetic process, mevalonate-independent
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of terpenoids, independent of mevalonate. Isopentenyl diphosphate (IPP) is the fundamental unit in terpenoid biosynthesis, and in mevalonate-independent biosynthesis, it is produced from pyruvate and glyceraldehyde 3-phosphate via intermediates including 1-deoxy-D-xylulose 5-phosphate." [GOC:ai]
synonym: "mevalonate-independent terpene biosynthesis" NARROW []
synonym: "mevalonate-independent terpene biosynthetic process" NARROW []
synonym: "mevalonate-independent terpenoid biosynthesis" EXACT []
synonym: "mevalonate-independent terpenoid biosynthetic process" EXACT []
synonym: "terpene biosynthesis, mevalonate-independent" NARROW []
synonym: "terpene biosynthetic process, mevalonate-independent" NARROW []
synonym: "terpenoid anabolism, mevalonate-independent" EXACT []
synonym: "terpenoid formation, mevalonate-independent" EXACT []
synonym: "terpenoid synthesis, mevalonate-independent" EXACT []
is_a: GO:0016114 ! terpenoid biosynthetic process

[Term]
id: GO:0051484
name: isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate-independent pathway that contributes to terpenoid biosynthesis. Isopentenyl diphosphate (IPP) is the fundamental unit in isoprenoid biosynthesis and is biosynthesized from pyruvate and glyceraldehyde 3-phosphate via intermediates, including 1-deoxy-D-xylulose 5-phosphate." [GOC:ai]
synonym: "isopentenyl diphosphate anabolism, mevalonate-independent pathway, during terpenoid anabolism" RELATED []
synonym: "isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway involved in terpenoid biosynthetic process" RELATED []
synonym: "isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway, during terpenoid biosynthetic process" RELATED [GOC:dph, GOC:tb]
synonym: "isopentenyl diphosphate formation, mevalonate-independent pathway, during terpenoid biosynthesis" RELATED []
synonym: "isopentenyl diphosphate formation, mevalonate-independent pathway, during terpenoid formation" RELATED []
synonym: "isopentenyl diphosphate synthesis, mevalonate-independent pathway, during terpenoid synthesis" RELATED []
xref: MetaCyc:NONMEVIPP-PWY
is_a: GO:0019288 ! isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
intersection_of: GO:0019288 ! isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
intersection_of: part_of GO:0016114 ! terpenoid biosynthetic process
relationship: part_of GO:0016114 ! terpenoid biosynthetic process
relationship: part_of GO:0051483 ! terpenoid biosynthetic process, mevalonate-independent

[Term]
id: GO:0051485
name: terpenoid biosynthetic process, mevalonate-dependent
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of terpenoids via isopentenyl diphosphate, synthesized by the mevalonate pathway. Isopentenyl diphosphate (IPP) is the fundamental unit in terpenoid biosynthesis, and in mevalonate-dependent terpenoid biosynthesis, acetate, in the form of acetyl-CoA, is converted to isopentenyl diphosphate (IPP) through a series of mevalonate intermediates." [GOC:ai]
synonym: "terpene biosynthesis, mevalonate-dependent" NARROW []
synonym: "terpene biosynthetic process, mevalonate-dependent" NARROW []
synonym: "terpenoid anabolism, mevalonate-dependent" EXACT []
synonym: "terpenoid formation, mevalonate-dependent" EXACT []
synonym: "terpenoid synthesis, mevalonate-dependent" EXACT []
is_a: GO:0016114 ! terpenoid biosynthetic process

[Term]
id: GO:0051486
name: isopentenyl diphosphate biosynthetic process, mevalonate pathway involved in terpenoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate pathway that contributes to terpenoid biosynthesis. This pathway converts acetate, in the form of acetyl-CoA, to isopentenyl diphosphate (IPP) through a series of mevalonate intermediates." [GOC:ai]
synonym: "isopentenyl diphosphate anabolism, mevalonate pathway, during terpenoid anabolism" RELATED []
synonym: "isopentenyl diphosphate biosynthetic process, mevalonate pathway, during terpenoid biosynthetic process" RELATED [GOC:dph, GOC:tb]
synonym: "isopentenyl diphosphate formation, mevalonate pathway, during terpenoid biosynthesis" RELATED []
synonym: "isopentenyl diphosphate formation, mevalonate pathway, during terpenoid formation" RELATED []
synonym: "isopentenyl diphosphate synthesis, mevalonate pathway, during terpenoid synthesis" RELATED []
is_a: GO:0019287 ! isopentenyl diphosphate biosynthetic process, mevalonate pathway
intersection_of: GO:0019287 ! isopentenyl diphosphate biosynthetic process, mevalonate pathway
intersection_of: part_of GO:0016114 ! terpenoid biosynthetic process
relationship: part_of GO:0016114 ! terpenoid biosynthetic process
relationship: part_of GO:0051485 ! terpenoid biosynthetic process, mevalonate-dependent

[Term]
id: GO:0051487
name: activation of anaphase-promoting complex activity involved in meiotic cell cycle
namespace: biological_process
def: "Any process that initiates the ubiquitin ligase activity of the anaphase-promoting complex during the meiotic cell cycle." [GOC:dph, GOC:mah, GOC:tb, PMID:10871297]
synonym: "activation of anaphase-promoting complex activity during meiotic cell cycle" RELATED [GOC:dph, GOC:tb]
synonym: "activation of ubiquitin ligase activity of anaphase promoting complex during meiotic cell cycle" RELATED []
synonym: "activation of ubiquitin ligase activity of anaphase-promoting complex during meiotic cell cycle" RELATED []
synonym: "activation of ubiquitin ligase activity of APC during meiotic cell cycle" RELATED []
synonym: "anaphase promoting complex activation during meiotic cell cycle" RELATED []
synonym: "anaphase-promoting complex activation during meiotic cell cycle" RELATED []
synonym: "APC activation during meiotic cell cycle" RELATED []
synonym: "meiotic anaphase promoting complex activation" RELATED []
synonym: "meiotic anaphase promoting complex activator" NARROW []
synonym: "meiotic anaphase-promoting complex activator" NARROW []
synonym: "meiotic APC activation" EXACT []
synonym: "meiotic APC activator" NARROW []
is_a: GO:0051441 ! positive regulation of ubiquitin-protein ligase activity involved in meiotic cell cycle
is_a: GO:0051488 ! activation of anaphase-promoting complex activity
intersection_of: GO:0051488 ! activation of anaphase-promoting complex activity
intersection_of: part_of GO:0051321 ! meiotic cell cycle
relationship: part_of GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0051488
name: activation of anaphase-promoting complex activity
namespace: biological_process
def: "Any process that initiates the ubiquitin ligase activity of the anaphase-promoting complex." [GOC:dph, GOC:mah, GOC:tb, PMID:10871297]
synonym: "activation of ubiquitin ligase activity of anaphase promoting complex" EXACT []
synonym: "activation of ubiquitin ligase activity of anaphase-promoting complex" EXACT []
synonym: "activation of ubiquitin ligase activity of APC" EXACT []
synonym: "anaphase promoting complex activation" EXACT []
synonym: "anaphase promoting complex activator" NARROW []
synonym: "anaphase-promoting complex activation" EXACT []
synonym: "anaphase-promoting complex activator" NARROW []
synonym: "APC activation" EXACT []
synonym: "APC activator" NARROW []
is_a: GO:0051443 ! positive regulation of ubiquitin-protein transferase activity

[Term]
id: GO:0051489
name: regulation of filopodium assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:ai, GOC:dph, GOC:tb]
synonym: "regulation of filopodia biosynthesis" EXACT []
synonym: "regulation of filopodia formation" EXACT []
synonym: "regulation of filopodium formation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0060491 ! regulation of cell projection assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0046847 ! filopodium assembly
relationship: regulates GO:0046847 ! filopodium assembly

[Term]
id: GO:0051490
name: negative regulation of filopodium assembly
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:ai]
synonym: "down regulation of filopodium formation" EXACT []
synonym: "down-regulation of filopodium formation" EXACT []
synonym: "downregulation of filopodium formation" EXACT []
synonym: "inhibition of filopodium formation" NARROW []
synonym: "negative regulation of filopodia biosynthesis" EXACT []
synonym: "negative regulation of filopodia formation" EXACT []
synonym: "negative regulation of filopodium formation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0031345 ! negative regulation of cell projection organization
is_a: GO:0051489 ! regulation of filopodium assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0046847 ! filopodium assembly
relationship: negatively_regulates GO:0046847 ! filopodium assembly

[Term]
id: GO:0051491
name: positive regulation of filopodium assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:ai, GOC:dph, GOC:tb]
synonym: "activation of filopodium formation" NARROW []
synonym: "positive regulation of filopodia biosynthesis" EXACT []
synonym: "positive regulation of filopodia formation" EXACT []
synonym: "positive regulation of filopodium formation" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of filopodium formation" NARROW []
synonym: "up regulation of filopodium formation" EXACT []
synonym: "up-regulation of filopodium formation" EXACT []
synonym: "upregulation of filopodium formation" EXACT []
is_a: GO:0031346 ! positive regulation of cell projection organization
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:0051489 ! regulation of filopodium assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0046847 ! filopodium assembly
relationship: positively_regulates GO:0046847 ! filopodium assembly

[Term]
id: GO:0051492
name: regulation of stress fiber assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts." [GOC:ai]
synonym: "regulation of stress fibre biosynthesis" RELATED []
synonym: "regulation of stress fibre formation" EXACT []
is_a: GO:0032231 ! regulation of actin filament bundle assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043149 ! stress fiber assembly
relationship: regulates GO:0043149 ! stress fiber assembly

[Term]
id: GO:0051493
name: regulation of cytoskeleton organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai]
synonym: "regulation of cytoskeleton organisation" EXACT [GOC:mah]
synonym: "regulation of cytoskeleton organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0033043 ! regulation of organelle organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007010 ! cytoskeleton organization
relationship: regulates GO:0007010 ! cytoskeleton organization

[Term]
id: GO:0051494
name: negative regulation of cytoskeleton organization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai]
synonym: "down regulation of cytoskeleton organization" EXACT []
synonym: "down-regulation of cytoskeleton organization" EXACT []
synonym: "downregulation of cytoskeleton organization" EXACT []
synonym: "inhibition of cytoskeleton organization" NARROW []
synonym: "negative regulation of cytoskeleton organisation" EXACT [GOC:mah]
synonym: "negative regulation of cytoskeleton organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:0051493 ! regulation of cytoskeleton organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007010 ! cytoskeleton organization
relationship: negatively_regulates GO:0007010 ! cytoskeleton organization

[Term]
id: GO:0051495
name: positive regulation of cytoskeleton organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai]
synonym: "activation of cytoskeleton organization" NARROW []
synonym: "positive regulation of cytoskeleton organisation" EXACT [GOC:mah]
synonym: "positive regulation of cytoskeleton organization and biogenesis" RELATED [GOC:mah]
synonym: "stimulation of cytoskeleton organization" NARROW []
synonym: "up regulation of cytoskeleton organization" EXACT []
synonym: "up-regulation of cytoskeleton organization" EXACT []
synonym: "upregulation of cytoskeleton organization" EXACT []
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:0051493 ! regulation of cytoskeleton organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007010 ! cytoskeleton organization
relationship: positively_regulates GO:0007010 ! cytoskeleton organization

[Term]
id: GO:0051496
name: positive regulation of stress fiber assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts." [GOC:ai]
synonym: "activation of stress fiber formation" NARROW []
synonym: "positive regulation of stress fibre biosynthesis" RELATED []
synonym: "positive regulation of stress fibre formation" RELATED []
synonym: "stimulation of stress fiber formation" NARROW []
synonym: "up regulation of stress fiber formation" RELATED []
synonym: "up-regulation of stress fiber formation" EXACT []
synonym: "upregulation of stress fiber formation" RELATED []
is_a: GO:0032233 ! positive regulation of actin filament bundle assembly
is_a: GO:0051492 ! regulation of stress fiber assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043149 ! stress fiber assembly
relationship: positively_regulates GO:0043149 ! stress fiber assembly

[Term]
id: GO:0051497
name: negative regulation of stress fiber assembly
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts." [GOC:ai]
synonym: "down regulation of stress fiber formation" RELATED []
synonym: "down-regulation of stress fiber formation" EXACT []
synonym: "downregulation of stress fiber formation" RELATED []
synonym: "inhibition of stress fiber formation" NARROW []
synonym: "negative regulation of stress fibre biosynthesis" RELATED []
synonym: "negative regulation of stress fibre formation" RELATED []
is_a: GO:0032232 ! negative regulation of actin filament bundle assembly
is_a: GO:0051492 ! regulation of stress fiber assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043149 ! stress fiber assembly
relationship: negatively_regulates GO:0043149 ! stress fiber assembly

[Term]
id: GO:0051498
name: syn-copalyl diphosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranylgeranyl diphosphate = 9alpha-copalyl diphosphate." [MetaCyc:RXN-8528]
synonym: "diterpene cyclase activity" BROAD []
xref: EC:5.5.1.14
xref: MetaCyc:RXN-8528
xref: RHEA:25527
is_a: GO:0016872 ! intramolecular lyase activity

[Term]
id: GO:0051499
name: D-aminoacyl-tRNA deacylase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-aminoacyl-tRNA = D-amino acid + tRNA. Hydrolysis of the removal of D-amino acids from residues in charged tRNA." [PMID:14527667]
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0051500
name: D-tyrosyl-tRNA(Tyr) deacylase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-tyrosyl-tRNA(Tyr) = D-tyrosine + tRNA(Tyr). Hydrolysis of the removal of D-tyrosine from tyrosine residues in charged tRNA." [PMID:14527667]
is_a: GO:0051499 ! D-aminoacyl-tRNA deacylase activity

[Term]
id: GO:0051501
name: diterpene phytoalexin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving diterpene phytoalexins, a class of diterpene formed in plants in response to fungal infection, physical damage, chemical injury, or a pathogenic process; they are sometimes referred to as plant antibiotics. Diterpenes are unsaturated hydrocarbons containing 20 carbon atoms and 4 branched methyl groups and are made up of isoprenoid units." [GOC:ai, http://www.onelook.com, ISBN:0721662544]
synonym: "diterpene phytoalexin metabolism" EXACT []
is_a: GO:0016101 ! diterpenoid metabolic process
is_a: GO:0052314 ! phytoalexin metabolic process

[Term]
id: GO:0051502
name: diterpene phytoalexin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of diterpene phytoalexins, terpenoids with 20 carbons produced by plants in response to environmental stresses." [GOC:ai]
synonym: "diterpene phytoalexin anabolism" EXACT []
synonym: "diterpene phytoalexin biosynthesis" EXACT []
synonym: "diterpene phytoalexin formation" EXACT []
synonym: "diterpene phytoalexin synthesis" EXACT []
is_a: GO:0016102 ! diterpenoid biosynthetic process
is_a: GO:0051501 ! diterpene phytoalexin metabolic process
is_a: GO:0052315 ! phytoalexin biosynthetic process

[Term]
id: GO:0051503
name: adenine nucleotide transport
namespace: biological_process
def: "The directed movement of adenine nucleotides, ATP, ADP, and/or AMP, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0015865 ! purine nucleotide transport

[Term]
id: GO:0051504
name: diterpene phytoalexin precursor biosynthetic process pathway
namespace: biological_process
def: "A branched pathway that produces the precursors to four structurally distinct types of polycyclic diterpenes. The pathway starts with the cyclization of geranylgeranyl diphosphate into ent-copalyl diphosphate and syn-copalyl diphosphate. The catalytic conversion by diterpene cyclases of these two compounds produces the four diterpene hydrocarbons which are precursors to the four structurally distinct classes of diterpene phytoalexins." [MetaCyc:PWY-2981]
synonym: "diterpene phytoalexin precursor anabolism pathway" EXACT []
synonym: "diterpene phytoalexin precursor formation pathway" EXACT []
synonym: "diterpene phytoalexin precursor synthesis pathway" EXACT []
xref: MetaCyc:PWY-2981
is_a: GO:0046246 ! terpene biosynthetic process
relationship: part_of GO:0051502 ! diterpene phytoalexin biosynthetic process

[Term]
id: GO:0051505
name: cholesterol UDP-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + a sterol = UDP + O-glucosyl-cholesterol." [GOC:ai]
is_a: GO:0016906 ! sterol 3-beta-glucosyltransferase activity

[Term]
id: GO:0051506
name: ergosterol UDP-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + a sterol = UDP + O-glucosyl-ergosterol." [GOC:ai]
is_a: GO:0016906 ! sterol 3-beta-glucosyltransferase activity

[Term]
id: GO:0051507
name: beta-sitosterol UDP-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + a sterol = UDP + O-glucosyl-beta-sitosterol." [GOC:ai]
is_a: GO:0016906 ! sterol 3-beta-glucosyltransferase activity

[Term]
id: GO:0051508
name: stigmasterol UDP-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + a sterol = UDP + O-glucosyl-stigmasterol." [GOC:ai]
is_a: GO:0016906 ! sterol 3-beta-glucosyltransferase activity

[Term]
id: GO:0051509
name: tomatidine UDP-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + a sterol = UDP + O-glucosyl-tomatidine." [GOC:ai]
is_a: GO:0016906 ! sterol 3-beta-glucosyltransferase activity

[Term]
id: GO:0051510
name: regulation of unidimensional cell growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of unidimensional cell growth, the process in which a cell irreversibly increases in size in one [spatial] dimension or along one axis." [GOC:ai]
is_a: GO:0001558 ! regulation of cell growth
is_a: GO:0022604 ! regulation of cell morphogenesis
is_a: GO:0048638 ! regulation of developmental growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009826 ! unidimensional cell growth
relationship: regulates GO:0009826 ! unidimensional cell growth

[Term]
id: GO:0051511
name: negative regulation of unidimensional cell growth
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of unidimensional cell growth, the process in which a cell irreversibly increases in size in one [spatial] dimension or along one axis." [GOC:ai]
synonym: "down regulation of unidimensional cell growth" EXACT []
synonym: "down-regulation of unidimensional cell growth" EXACT []
synonym: "downregulation of unidimensional cell growth" EXACT []
synonym: "inhibition of unidimensional cell growth" NARROW []
is_a: GO:0030308 ! negative regulation of cell growth
is_a: GO:0048640 ! negative regulation of developmental growth
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:0051510 ! regulation of unidimensional cell growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009826 ! unidimensional cell growth
relationship: negatively_regulates GO:0009826 ! unidimensional cell growth

[Term]
id: GO:0051512
name: positive regulation of unidimensional cell growth
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of unidimensional cell growth, the process in which a cell irreversibly increases in size in one [spatial] dimension or along one axis." [GOC:ai]
synonym: "activation of unidimensional cell growth" NARROW []
synonym: "stimulation of unidimensional cell growth" NARROW []
synonym: "up regulation of unidimensional cell growth" EXACT []
synonym: "up-regulation of unidimensional cell growth" EXACT []
synonym: "upregulation of unidimensional cell growth" EXACT []
is_a: GO:0030307 ! positive regulation of cell growth
is_a: GO:0048639 ! positive regulation of developmental growth
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:0051510 ! regulation of unidimensional cell growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009826 ! unidimensional cell growth
relationship: positively_regulates GO:0009826 ! unidimensional cell growth

[Term]
id: GO:0051513
name: regulation of monopolar cell growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of monopolar cell growth, polarized growth from one end of a cell." [GOC:ai]
is_a: GO:0051510 ! regulation of unidimensional cell growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042814 ! monopolar cell growth
relationship: regulates GO:0042814 ! monopolar cell growth

[Term]
id: GO:0051514
name: negative regulation of monopolar cell growth
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of monopolar cell growth, polarized growth from one end of a cell." [GOC:ai]
synonym: "down regulation of monopolar cell growth" EXACT []
synonym: "down-regulation of monopolar cell growth" EXACT []
synonym: "downregulation of monopolar cell growth" EXACT []
synonym: "inhibition of monopolar cell growth" NARROW []
is_a: GO:0051511 ! negative regulation of unidimensional cell growth
is_a: GO:0051513 ! regulation of monopolar cell growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042814 ! monopolar cell growth
relationship: negatively_regulates GO:0042814 ! monopolar cell growth

[Term]
id: GO:0051515
name: positive regulation of monopolar cell growth
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of monopolar cell growth, polarized growth from one end of a cell." [GOC:ai]
synonym: "stimulation of monopolar cell growth" NARROW []
synonym: "up regulation of monopolar cell growth" EXACT []
synonym: "up-regulation of monopolar cell growth" EXACT []
synonym: "upregulation of monopolar cell growth" EXACT []
is_a: GO:0051512 ! positive regulation of unidimensional cell growth
is_a: GO:0051513 ! regulation of monopolar cell growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042814 ! monopolar cell growth
relationship: positively_regulates GO:0042814 ! monopolar cell growth

[Term]
id: GO:0051516
name: regulation of bipolar cell growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of bipolar cell growth, polarized growth from both ends of a cell." [GOC:ai]
is_a: GO:0051510 ! regulation of unidimensional cell growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042815 ! bipolar cell growth
relationship: regulates GO:0042815 ! bipolar cell growth

[Term]
id: GO:0051517
name: negative regulation of bipolar cell growth
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of bipolar cell growth, polarized growth from both ends of a cell." [GOC:ai]
synonym: "down regulation of bipolar cell growth" EXACT []
synonym: "down-regulation of bipolar cell growth" EXACT []
synonym: "downregulation of bipolar cell growth" EXACT []
synonym: "inhibition of bipolar cell growth" NARROW []
is_a: GO:0051511 ! negative regulation of unidimensional cell growth
is_a: GO:0051516 ! regulation of bipolar cell growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042815 ! bipolar cell growth
relationship: negatively_regulates GO:0042815 ! bipolar cell growth

[Term]
id: GO:0051518
name: positive regulation of bipolar cell growth
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of bipolar cell growth, polarized growth from both ends of a cell." [GOC:ai]
synonym: "stimulation of bipolar cell growth" NARROW []
synonym: "up regulation of bipolar cell growth" EXACT []
synonym: "up-regulation of bipolar cell growth" EXACT []
synonym: "upregulation of bipolar cell growth" EXACT []
is_a: GO:0051512 ! positive regulation of unidimensional cell growth
is_a: GO:0051516 ! regulation of bipolar cell growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042815 ! bipolar cell growth
relationship: positively_regulates GO:0042815 ! bipolar cell growth

[Term]
id: GO:0051519
name: activation of bipolar cell growth
namespace: biological_process
def: "Any process that initiates the inactive process of bipolar cell growth, polarized growth from both ends of a cell." [GOC:ai]
synonym: "NETO" EXACT [GOC:mah, GOC:vw]
synonym: "new end take off" EXACT [GOC:mah, GOC:vw]
is_a: GO:0051518 ! positive regulation of bipolar cell growth

[Term]
id: GO:0051520
name: termination of bipolar cell growth
namespace: biological_process
def: "Any process that stops the active process of bipolar cell growth, polarized growth from both ends of a cell." [GOC:ai]
is_a: GO:0051517 ! negative regulation of bipolar cell growth

[Term]
id: GO:0051521
name: termination of monopolar cell growth
namespace: biological_process
def: "Any process that stops the active process of bipolar cell growth, polarized growth from one end of a cell." [GOC:ai]
is_a: GO:0051514 ! negative regulation of monopolar cell growth

[Term]
id: GO:0051522
name: activation of monopolar cell growth
namespace: biological_process
def: "Any process that initiates the inactive process of monopolar cell growth, polarized growth from one end of a cell." [GOC:ai]
is_a: GO:0051515 ! positive regulation of monopolar cell growth

[Term]
id: GO:0051523
name: cell growth mode switching, monopolar to bipolar
namespace: biological_process
def: "The process in which a cell switches from monopolar cell growth to bipolar cell growth." [GOC:ai]
is_a: GO:0051519 ! activation of bipolar cell growth
is_a: GO:0061389 ! regulation of direction of cell growth

[Term]
id: GO:0051524
name: cell growth mode switching, bipolar to monopolar
namespace: biological_process
def: "The process in which a cell switches from bipolar cell growth to monopolar cell growth." [GOC:ai]
is_a: GO:0051510 ! regulation of unidimensional cell growth
is_a: GO:0061389 ! regulation of direction of cell growth

[Term]
id: GO:0051525
name: NFAT protein binding
namespace: molecular_function
alt_id: GO:0051526
alt_id: GO:0051527
alt_id: GO:0051528
alt_id: GO:0051529
alt_id: GO:0051530
def: "Interacting selectively and non-covalently with NFAT (nuclear factor of activated T cells) proteins, a family of transcription factors. NFAT proteins have crucial roles in the development and function of the immune system." [PMID:15928679]
synonym: "NFAT binding" EXACT []
synonym: "NFAT1 protein binding" NARROW []
synonym: "NFAT2 protein binding" NARROW []
synonym: "NFAT3 protein binding" NARROW []
synonym: "NFAT4 protein binding" NARROW []
synonym: "NFAT5 protein binding" NARROW []
synonym: "NFATc binding" NARROW []
synonym: "NFATc1 binding" NARROW []
synonym: "NFATc2 binding" NARROW []
synonym: "NFATc3 binding" NARROW []
synonym: "NFATc4 binding" NARROW []
synonym: "NFATp binding" NARROW []
synonym: "NFATx binding" NARROW []
synonym: "non-calcium-regulated NFAT protein binding" NARROW []
synonym: "nuclear factor of activated T cell protein binding" EXACT []
is_a: GO:0008134 ! transcription factor binding

[Term]
id: GO:0051531
name: NFAT protein import into nucleus
namespace: biological_process
def: "The directed movement of NFAT (nuclear factor of activated T cells) proteins, a family of transcription factors, from the cytoplasm into the nucleus. NFAT proteins are dephosphorylated in the cytoplasm by activated calcineurin, which leads to their translocation across the nuclear membrane." [PMID:11983154, PMID:15870113, PMID:15928679]
synonym: "NFAT protein import into cell nucleus" EXACT []
synonym: "NFAT protein nuclear translocation" EXACT []
synonym: "NFAT protein nucleus import" EXACT []
synonym: "NFAT protein transport from cytoplasm to nucleus" EXACT []
synonym: "NFAT protein-nucleus import" EXACT []
is_a: GO:0042991 ! transcription factor import into nucleus

[Term]
id: GO:0051532
name: regulation of NFAT protein import into nucleus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the movement of an NFAT protein from the cytoplasm to the nucleus." [GOC:ai]
synonym: "regulation of NFAT protein import into cell nucleus" EXACT []
synonym: "regulation of NFAT protein transport from cytoplasm to nucleus" EXACT []
synonym: "regulation of NFAT protein-nucleus import" EXACT []
is_a: GO:0042990 ! regulation of transcription factor import into nucleus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051531 ! NFAT protein import into nucleus
relationship: regulates GO:0051531 ! NFAT protein import into nucleus

[Term]
id: GO:0051533
name: positive regulation of NFAT protein import into nucleus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the movement of an NFAT protein from the cytoplasm to the nucleus." [GOC:ai]
synonym: "activation of NFAT protein import into nucleus" NARROW []
synonym: "positive regulation of NFAT protein import into cell nucleus" EXACT []
synonym: "positive regulation of NFAT protein transport from cytoplasm to nucleus" EXACT []
synonym: "positive regulation of NFAT protein-nucleus import" EXACT []
synonym: "stimulation of NFAT protein import into nucleus" NARROW []
synonym: "up regulation of NFAT protein import into nucleus" EXACT []
synonym: "up-regulation of NFAT protein import into nucleus" EXACT []
synonym: "upregulation of NFAT protein import into nucleus" EXACT []
is_a: GO:0042993 ! positive regulation of transcription factor import into nucleus
is_a: GO:0051532 ! regulation of NFAT protein import into nucleus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051531 ! NFAT protein import into nucleus
relationship: positively_regulates GO:0051531 ! NFAT protein import into nucleus

[Term]
id: GO:0051534
name: negative regulation of NFAT protein import into nucleus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of an NFAT protein from the cytoplasm to the nucleus." [GOC:ai]
synonym: "down regulation of NFAT protein import into nucleus" EXACT []
synonym: "down-regulation of NFAT protein import into nucleus" EXACT []
synonym: "downregulation of NFAT protein import into nucleus" EXACT []
synonym: "inhibition of NFAT protein import into nucleus" NARROW []
synonym: "negative regulation of NFAT protein import into cell nucleus" EXACT []
synonym: "negative regulation of NFAT protein transport from cytoplasm to nucleus" EXACT []
synonym: "negative regulation of NFAT protein-nucleus import" EXACT []
is_a: GO:0042992 ! negative regulation of transcription factor import into nucleus
is_a: GO:0051532 ! regulation of NFAT protein import into nucleus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051531 ! NFAT protein import into nucleus
relationship: negatively_regulates GO:0051531 ! NFAT protein import into nucleus

[Term]
id: GO:0051536
name: iron-sulfur cluster binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]
synonym: "Fe/S binding" EXACT []
synonym: "iron sulfur cluster binding" EXACT []
synonym: "iron sulphur cluster binding" EXACT []
synonym: "iron-sulphur cluster binding" EXACT []
is_a: GO:0051540 ! metal cluster binding

[Term]
id: GO:0051537
name: 2 iron, 2 sulfur cluster binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]
synonym: "2 Fe 2 S cluster binding" EXACT []
synonym: "2 iron, 2 sulphur cluster binding" EXACT []
synonym: "2Fe-2S cluster binding" EXACT []
synonym: "diiron disulfide cluster binding" EXACT []
synonym: "diiron disulphide cluster binding" EXACT []
synonym: "iron-sulfur cluster 2Fe-2S binding" EXACT []
synonym: "iron-sulphur cluster 2Fe-2S binding" EXACT []
is_a: GO:0051536 ! iron-sulfur cluster binding

[Term]
id: GO:0051538
name: 3 iron, 4 sulfur cluster binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a 3 iron, 4 sulfur (3Fe-4S) cluster; this cluster consists of three iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. It is essentially a 4Fe-4S cluster with one iron missing." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]
synonym: "3 Fe 4 S cluster binding" EXACT []
synonym: "3 iron, 4 sulphur cluster binding" EXACT []
synonym: "3Fe-4S cluster binding" EXACT []
synonym: "iron-sulfur cluster 3Fe-4S binding" EXACT []
synonym: "iron-sulphur cluster 3Fe-4S binding" EXACT []
synonym: "triiron tetrasulfide cluster binding" EXACT []
synonym: "triiron tetrasulphide cluster binding" EXACT []
is_a: GO:0051536 ! iron-sulfur cluster binding

[Term]
id: GO:0051539
name: 4 iron, 4 sulfur cluster binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]
synonym: "4 Fe 4 S cluster binding" EXACT []
synonym: "4 iron, 4 sulphur cluster binding" EXACT []
synonym: "4Fe-4S cluster binding" EXACT []
synonym: "iron-sulfur cluster 4Fe-4S binding" EXACT []
synonym: "iron-sulphur cluster 4Fe-4S binding" EXACT []
synonym: "tetrairon tetrasulfide cluster binding" EXACT []
synonym: "tetrairon tetrasulphide cluster binding" EXACT []
is_a: GO:0051536 ! iron-sulfur cluster binding

[Term]
id: GO:0051540
name: metal cluster binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a cluster of atoms including both metal ions and nonmetal atoms, usually sulfur and oxygen. Examples include iron-sulfur clusters and nickel-iron-sulfur clusters." [GOC:jsg]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0051541
name: elastin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving elastin, a glycoprotein which is randomly coiled and crosslinked to form elastic fibers that are found in connective tissue." [http://www.onelook.com]
synonym: "elastin metabolism" EXACT []
is_a: GO:0009100 ! glycoprotein metabolic process

[Term]
id: GO:0051542
name: elastin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of elastin, a fibrous glycoprotein found in elastic tissues such as the walls of arteries." [GOC:ai]
is_a: GO:0009101 ! glycoprotein biosynthetic process
is_a: GO:0051541 ! elastin metabolic process

[Term]
id: GO:0051543
name: regulation of elastin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of elastin." [GOC:ai]
is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051542 ! elastin biosynthetic process
relationship: regulates GO:0051542 ! elastin biosynthetic process

[Term]
id: GO:0051544
name: positive regulation of elastin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of elastin." [GOC:ai]
synonym: "activation of elastin biosynthetic process" NARROW []
synonym: "stimulation of elastin biosynthetic process" NARROW []
synonym: "up regulation of elastin biosynthetic process" EXACT []
synonym: "up-regulation of elastin biosynthetic process" EXACT []
synonym: "upregulation of elastin biosynthetic process" EXACT []
is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process
is_a: GO:0051543 ! regulation of elastin biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051542 ! elastin biosynthetic process
relationship: positively_regulates GO:0051542 ! elastin biosynthetic process

[Term]
id: GO:0051545
name: negative regulation of elastin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of elastin." [GOC:ai]
synonym: "down regulation of elastin biosynthetic process" EXACT []
synonym: "down-regulation of elastin biosynthetic process" EXACT []
synonym: "downregulation of elastin biosynthetic process" EXACT []
synonym: "inhibition of elastin biosynthetic process" NARROW []
is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process
is_a: GO:0051543 ! regulation of elastin biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051542 ! elastin biosynthetic process
relationship: negatively_regulates GO:0051542 ! elastin biosynthetic process

[Term]
id: GO:0051546
name: keratinocyte migration
namespace: biological_process
def: "The directed movement of a keratinocyte, epidermal cells which synthesize keratin, from one site to another." [ISBN:0721662544]
is_a: GO:0010631 ! epithelial cell migration

[Term]
id: GO:0051547
name: regulation of keratinocyte migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of keratinocyte migration." [GOC:ai]
is_a: GO:0010632 ! regulation of epithelial cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051546 ! keratinocyte migration
relationship: regulates GO:0051546 ! keratinocyte migration

[Term]
id: GO:0051548
name: negative regulation of keratinocyte migration
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of keratinocyte migration." [GOC:ai]
synonym: "down regulation of keratinocyte migration" EXACT []
synonym: "down-regulation of keratinocyte migration" EXACT []
synonym: "downregulation of keratinocyte migration" EXACT []
synonym: "inhibition of keratinocyte migration" NARROW []
is_a: GO:0010633 ! negative regulation of epithelial cell migration
is_a: GO:0051547 ! regulation of keratinocyte migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051546 ! keratinocyte migration
relationship: negatively_regulates GO:0051546 ! keratinocyte migration

[Term]
id: GO:0051549
name: positive regulation of keratinocyte migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of keratinocyte migration." [GOC:ai]
synonym: "activation of keratinocyte migration" NARROW []
synonym: "stimulation of keratinocyte migration" NARROW []
synonym: "up regulation of keratinocyte migration" EXACT []
synonym: "up-regulation of keratinocyte migration" EXACT []
synonym: "upregulation of keratinocyte migration" EXACT []
is_a: GO:0010634 ! positive regulation of epithelial cell migration
is_a: GO:0051547 ! regulation of keratinocyte migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051546 ! keratinocyte migration
relationship: positively_regulates GO:0051546 ! keratinocyte migration

[Term]
id: GO:0051550
name: aurone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aurones, a series of plant flavonoids that provide a yellow colour to flowers. They have the basic skeletal structure of two benzene rings joined by a linear C3 chain (C6-C3-C6). Aurones exist mostly as 6-O-glucosides." [CHEBI:47964, GOC:curators]
synonym: "aurone metabolism" EXACT []
synonym: "benzalcoumaran-3-one metabolic process" EXACT []
synonym: "benzalcoumaran-3-one metabolism" EXACT []
is_a: GO:0009812 ! flavonoid metabolic process
is_a: GO:0042180 ! cellular ketone metabolic process
is_a: GO:0042440 ! pigment metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process

[Term]
id: GO:0051551
name: aurone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of aurones, a series of yellow plant pigments." [GOC:ai]
synonym: "benzalcoumaran-3-one biosynthesis" EXACT []
synonym: "benzalcoumaran-3-one biosynthetic process" EXACT []
is_a: GO:0009813 ! flavonoid biosynthetic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0046148 ! pigment biosynthetic process
is_a: GO:0051550 ! aurone metabolic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process

[Term]
id: GO:0051552
name: flavone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving flavones, a class of pigmented plant compounds based on 2-phenyl-4H-1-benzopyran-4-one (2-phenylchromone)." [http://www.onelook.com]
synonym: "2-phenyl-4H-1-benzopyran-4-one metabolic process" NARROW []
synonym: "2-phenyl-4H-1-benzopyran-4-one metabolism" NARROW []
synonym: "2-phenylchromone metabolic process" NARROW []
synonym: "2-phenylchromone metabolism" NARROW []
synonym: "flavone metabolism" EXACT []
is_a: GO:0009812 ! flavonoid metabolic process
is_a: GO:0042440 ! pigment metabolic process

[Term]
id: GO:0051553
name: flavone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of flavones, a class of pigmented plant compounds based on 2-phenyl-4H-1-benzopyran-4-one (2-phenylchromone)." [GOC:ai]
synonym: "2-phenyl-4H-1-benzopyran-4-one biosynthesis" NARROW []
synonym: "2-phenyl-4H-1-benzopyran-4-one biosynthetic process" NARROW []
synonym: "2-phenylchromone biosynthesis" NARROW []
synonym: "2-phenylchromone biosynthetic process" NARROW []
is_a: GO:0009813 ! flavonoid biosynthetic process
is_a: GO:0046148 ! pigment biosynthetic process
is_a: GO:0051552 ! flavone metabolic process

[Term]
id: GO:0051554
name: flavonol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving flavonols, a member of a class of vascular pigments formed by consecutive oxidative processes from the flavonoid intermediates flavanones and dihydroflavonols. Flavonols are the most widespread of the flavonoids and have a wide array of physiological activities." [PMID:11402179]
synonym: "flavonol metabolism" EXACT []
is_a: GO:0051552 ! flavone metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process

[Term]
id: GO:0051555
name: flavonol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of flavonols, a member of a class of vascular pigments formed by consecutive oxidative processes from the flavonoid intermediates flavanones and dihydroflavonols. Flavonols are the most widespread of the flavonoids and have a wide array of physiological activities." [GOC:ai]
xref: MetaCyc:PWY-3101
is_a: GO:0051553 ! flavone biosynthetic process
is_a: GO:0051554 ! flavonol metabolic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process

[Term]
id: GO:0051556
name: leucoanthocyanidin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving leucoanthocyanidins, a class of colorless intermediates in the biosynthetic pathway of the pigmented flavonoids." [GOC:ai]
synonym: "leucoanthocyanidin metabolism" EXACT []
xref: MetaCyc:PWY1F-823
is_a: GO:0009698 ! phenylpropanoid metabolic process
is_a: GO:0009812 ! flavonoid metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process

[Term]
id: GO:0051557
name: leucoanthocyanidin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of leucoanthocyanidins, a class of colorless intermediates in the biosynthetic pathway of the pigmented flavonoids." [GOC:ai]
is_a: GO:0009699 ! phenylpropanoid biosynthetic process
is_a: GO:0009813 ! flavonoid biosynthetic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0051556 ! leucoanthocyanidin metabolic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process

[Term]
id: GO:0051558
name: phlobaphene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phlobaphenes, red pigments with oligomeric or polymeric structure derived from the flavonoid intermediate flavan-4-ols." [PMID:11402179]
synonym: "phlobaphene metabolism" EXACT []
is_a: GO:0042440 ! pigment metabolic process

[Term]
id: GO:0051559
name: phlobaphene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phlobaphenes, red pigments with oligomeric or polymeric structure derived from the flavonoid intermediate flavan-4-ols." [PMID:11402179]
is_a: GO:0046148 ! pigment biosynthetic process
is_a: GO:0051558 ! phlobaphene metabolic process

[Term]
id: GO:0051560
name: mitochondrial calcium ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings." [GOC:ai, GOC:mah]
synonym: "calcium ion homeostasis in mitochondria" EXACT []
synonym: "calcium ion homeostasis in mitochondrion" EXACT []
synonym: "mitochondrial calcium ion concentration regulation" EXACT []
synonym: "regulation of calcium ion concentration in mitochondria" EXACT []
synonym: "regulation of calcium ion concentration in mitochondrion" EXACT []
synonym: "regulation of mitochondrial calcium ion concentration" EXACT []
is_a: GO:0006874 ! cellular calcium ion homeostasis
intersection_of: GO:0055074 ! calcium ion homeostasis
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion

[Term]
id: GO:0051561
name: positive regulation of mitochondrial calcium ion concentration
namespace: biological_process
def: "Any process that increases the concentration of calcium ions in mitochondria." [GOC:ai]
synonym: "elevation of calcium ion concentration in mitochondria" EXACT []
synonym: "elevation of calcium ion concentration in mitochondrion" EXACT []
synonym: "elevation of mitochondrial calcium ion concentration" EXACT []
synonym: "mitochondrial calcium ion concentration elevation" EXACT []
is_a: GO:0051560 ! mitochondrial calcium ion homeostasis

[Term]
id: GO:0051562
name: negative regulation of mitochondrial calcium ion concentration
namespace: biological_process
def: "Any process that decreases the concentration of calcium ions in mitochondria." [GOC:ai]
synonym: "mitochondrial calcium ion concentration reduction" EXACT []
synonym: "reduction of calcium ion concentration in mitochondria" EXACT []
synonym: "reduction of calcium ion concentration in mitochondrion" EXACT []
synonym: "reduction of mitochondrial calcium ion concentration" EXACT []
is_a: GO:0051560 ! mitochondrial calcium ion homeostasis

[Term]
id: GO:0051563
name: smooth endoplasmic reticulum calcium ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of calcium ions within the smooth endoplasmic reticulum of a cell or between the smooth endoplasmic reticulum and its surroundings." [GOC:ai, GOC:mah]
synonym: "calcium ion homeostasis in smooth endoplasmic reticulum" EXACT []
synonym: "calcium ion homeostasis in smooth ER" EXACT []
synonym: "regulation of calcium ion concentration in smooth endoplasmic reticulum" EXACT []
synonym: "regulation of calcium ion concentration in smooth ER" EXACT []
synonym: "regulation of smooth endoplasmic reticulum calcium ion concentration" EXACT []
synonym: "regulation of smooth ER calcium ion concentration" EXACT []
synonym: "smooth endoplasmic reticulum calcium ion concentration regulation" EXACT []
synonym: "smooth ER calcium ion concentration regulation" EXACT []
synonym: "smooth ER calcium ion homeostasis" EXACT []
is_a: GO:0032469 ! endoplasmic reticulum calcium ion homeostasis
intersection_of: GO:0055074 ! calcium ion homeostasis
intersection_of: occurs_in GO:0005790 ! smooth endoplasmic reticulum
relationship: occurs_in GO:0005790 ! smooth endoplasmic reticulum

[Term]
id: GO:0051564
name: positive regulation of smooth endoplasmic reticulum calcium ion concentration
namespace: biological_process
def: "Any process that increases the concentration of calcium ions in the smooth endoplasmic reticulum." [GOC:ai]
synonym: "elevation of calcium ion concentration in smooth endoplasmic reticulum" EXACT []
synonym: "elevation of smooth endoplasmic reticulum calcium ion concentration" EXACT []
synonym: "elevation of smooth ER calcium ion concentration" EXACT []
synonym: "smooth endoplasmic reticulum calcium ion concentration elevation" EXACT []
is_a: GO:0032470 ! positive regulation of endoplasmic reticulum calcium ion concentration
is_a: GO:0051563 ! smooth endoplasmic reticulum calcium ion homeostasis

[Term]
id: GO:0051565
name: negative regulation of smooth endoplasmic reticulum calcium ion concentration
namespace: biological_process
def: "Any process that decreases the concentration of calcium ions in the smooth endoplasmic reticulum." [GOC:ai]
synonym: "reduction of calcium ion concentration in smooth endoplasmic reticulum" EXACT []
synonym: "reduction of calcium ion concentration in smooth ER" EXACT []
synonym: "reduction of smooth endoplasmic reticulum calcium ion concentration" EXACT []
synonym: "reduction of smooth ER calcium ion concentration" EXACT []
synonym: "smooth endoplasmic reticulum calcium ion concentration reduction" EXACT []
synonym: "smooth ER calcium ion concentration reduction" EXACT []
is_a: GO:0032471 ! negative regulation of endoplasmic reticulum calcium ion concentration
is_a: GO:0051563 ! smooth endoplasmic reticulum calcium ion homeostasis

[Term]
id: GO:0051566
name: anthocyanidin-3-glucoside rhamnosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: anthocyanidin 3-glucoside + UDP-rhamnose = anthocyanidin 3-rutinoside + UDP." [PMID:8130800]
synonym: "3RT activity" BROAD []
synonym: "anthocyanidin 3-glucoside-rhamnosyltransferase activity" EXACT []
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0051567
name: histone H3-K9 methylation
namespace: biological_process
def: "The modification of histone H3 by addition of one or more methyl groups to lysine at position 9 of the histone." [GOC:ai, GOC:pr]
synonym: "histone H3 K9 methylation" EXACT []
synonym: "histone H3K9me" EXACT []
synonym: "histone lysine H3 K9 methylation" EXACT []
is_a: GO:0034968 ! histone lysine methylation
is_a: GO:0061647 ! histone H3-K9 modification

[Term]
id: GO:0051568
name: histone H3-K4 methylation
namespace: biological_process
def: "The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone." [GOC:ai, GOC:pr]
synonym: "histone H3 K4 methylation" EXACT []
synonym: "histone H3K4me" EXACT []
synonym: "histone lysine H3 K4 methylation" EXACT []
is_a: GO:0034968 ! histone lysine methylation

[Term]
id: GO:0051569
name: regulation of histone H3-K4 methylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3." [GOC:ai]
is_a: GO:0031060 ! regulation of histone methylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051568 ! histone H3-K4 methylation
relationship: regulates GO:0051568 ! histone H3-K4 methylation

[Term]
id: GO:0051570
name: regulation of histone H3-K9 methylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3." [GOC:ai]
is_a: GO:0031060 ! regulation of histone methylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051567 ! histone H3-K9 methylation
relationship: regulates GO:0051567 ! histone H3-K9 methylation

[Term]
id: GO:0051571
name: positive regulation of histone H3-K4 methylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3." [GOC:mah]
synonym: "activation of histone H3-K4 methylation" NARROW []
synonym: "stimulation of histone H3-K4 methylation" NARROW []
synonym: "up regulation of histone H3-K4 methylation" EXACT []
synonym: "up-regulation of histone H3-K4 methylation" EXACT []
synonym: "upregulation of histone H3-K4 methylation" EXACT []
is_a: GO:0031062 ! positive regulation of histone methylation
is_a: GO:0051569 ! regulation of histone H3-K4 methylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051568 ! histone H3-K4 methylation
relationship: positively_regulates GO:0051568 ! histone H3-K4 methylation

[Term]
id: GO:0051572
name: negative regulation of histone H3-K4 methylation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3." [GOC:mah]
synonym: "down regulation of histone H3-K4 methylation" EXACT []
synonym: "down-regulation of histone H3-K4 methylation" EXACT []
synonym: "downregulation of histone H3-K4 methylation" EXACT []
synonym: "inhibition of histone H3-K4 methylation" NARROW []
is_a: GO:0031061 ! negative regulation of histone methylation
is_a: GO:0051569 ! regulation of histone H3-K4 methylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051568 ! histone H3-K4 methylation
relationship: negatively_regulates GO:0051568 ! histone H3-K4 methylation

[Term]
id: GO:0051573
name: negative regulation of histone H3-K9 methylation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3." [GOC:ai]
synonym: "down regulation of histone H3-K9 methylation" EXACT []
synonym: "down-regulation of histone H3-K9 methylation" EXACT []
synonym: "downregulation of histone H3-K9 methylation" EXACT []
synonym: "inhibition of histone H3-K9 methylation" NARROW []
is_a: GO:0031061 ! negative regulation of histone methylation
is_a: GO:0051570 ! regulation of histone H3-K9 methylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051567 ! histone H3-K9 methylation
relationship: negatively_regulates GO:0051567 ! histone H3-K9 methylation

[Term]
id: GO:0051574
name: positive regulation of histone H3-K9 methylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3." [GOC:ai]
synonym: "activation of histone H3-K9 methylation" NARROW []
synonym: "stimulation of histone H3-K9 methylation" NARROW []
synonym: "up regulation of histone H3-K9 methylation" EXACT []
synonym: "up-regulation of histone H3-K9 methylation" EXACT []
synonym: "upregulation of histone H3-K9 methylation" EXACT []
is_a: GO:0031062 ! positive regulation of histone methylation
is_a: GO:0051570 ! regulation of histone H3-K9 methylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051567 ! histone H3-K9 methylation
relationship: positively_regulates GO:0051567 ! histone H3-K9 methylation

[Term]
id: GO:0051575
name: 5'-deoxyribose-5-phosphate lyase activity
namespace: molecular_function
def: "Catalysis of the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site in DNA where a DNA-(apurinic or apyrimidinic site) lyase has already cleaved the C-O-P bond 3' to the apurinic or apyrimidinic site." [PMID:11251121, PMID:16120966]
synonym: "5'-deoxyribose phosphate activity" EXACT []
synonym: "dRP lyase activity" BROAD []
synonym: "dRPase activity" BROAD []
is_a: GO:0016835 ! carbon-oxygen lyase activity

[Term]
id: GO:0051580
name: regulation of neurotransmitter uptake
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell." [GOC:ai]
synonym: "regulation of neurotransmitter import" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of neurotransmitter reuptake" EXACT []
is_a: GO:0001505 ! regulation of neurotransmitter levels
is_a: GO:0050804 ! modulation of synaptic transmission
is_a: GO:0051588 ! regulation of neurotransmitter transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001504 ! neurotransmitter uptake
relationship: regulates GO:0001504 ! neurotransmitter uptake

[Term]
id: GO:0051581
name: negative regulation of neurotransmitter uptake
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell." [GOC:ai]
synonym: "down regulation of neurotransmitter uptake" EXACT []
synonym: "down-regulation of neurotransmitter uptake" EXACT []
synonym: "downregulation of neurotransmitter uptake" EXACT []
synonym: "negative regulation of neurotransmitter import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0050805 ! negative regulation of synaptic transmission
is_a: GO:0051580 ! regulation of neurotransmitter uptake
is_a: GO:0051589 ! negative regulation of neurotransmitter transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001504 ! neurotransmitter uptake
relationship: negatively_regulates GO:0001504 ! neurotransmitter uptake

[Term]
id: GO:0051582
name: positive regulation of neurotransmitter uptake
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell." [GOC:ai]
synonym: "activation of neurotransmitter uptake" NARROW []
synonym: "positive regulation of neurotransmitter import" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of neurotransmitter uptake" NARROW []
synonym: "up regulation of neurotransmitter uptake" EXACT []
synonym: "up-regulation of neurotransmitter uptake" EXACT []
synonym: "upregulation of neurotransmitter uptake" EXACT []
is_a: GO:0050806 ! positive regulation of synaptic transmission
is_a: GO:0051580 ! regulation of neurotransmitter uptake
is_a: GO:0051590 ! positive regulation of neurotransmitter transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001504 ! neurotransmitter uptake
relationship: positively_regulates GO:0001504 ! neurotransmitter uptake

[Term]
id: GO:0051583
name: dopamine uptake involved in synaptic transmission
namespace: biological_process
def: "The directed movement of dopamine into a presynaptic neuron or glial cell. In this context, dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:ai]
synonym: "dopamine import involved in synaptic transmission" EXACT [GOC:dph, GOC:tb]
synonym: "dopamine reuptake involved in synaptic transmission" EXACT []
is_a: GO:0051934 ! catecholamine uptake involved in synaptic transmission
is_a: GO:0090494 ! dopamine uptake
is_a: GO:0099531 ! presynaptic process involved in synaptic transmission
relationship: part_of GO:0001963 ! synaptic transmission, dopaminergic

[Term]
id: GO:0051584
name: regulation of dopamine uptake involved in synaptic transmission
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of the catecholamine neurotransmitter dopamine into a cell." [GOC:ai]
synonym: "regulation of dopamine import involved in synaptic transmission" EXACT [GOC:dph, GOC:tb]
is_a: GO:0032225 ! regulation of synaptic transmission, dopaminergic
is_a: GO:0044070 ! regulation of anion transport
is_a: GO:0051940 ! regulation of catecholamine uptake involved in synaptic transmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051583 ! dopamine uptake involved in synaptic transmission
relationship: regulates GO:0051583 ! dopamine uptake involved in synaptic transmission

[Term]
id: GO:0051585
name: negative regulation of dopamine uptake involved in synaptic transmission
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of dopamine into a presynaptic neuron or glial cell." [GOC:ai]
synonym: "down regulation of dopamine uptake involved in synaptic transmission" EXACT []
synonym: "down-regulation of dopamine uptake involved in synaptic transmission" EXACT []
synonym: "downregulation of dopamine uptake involved in synaptic transmission" EXACT []
synonym: "negative regulation of dopamine import involved in synaptic transmission" EXACT [GOC:dph, GOC:tb]
is_a: GO:0032227 ! negative regulation of synaptic transmission, dopaminergic
is_a: GO:0051584 ! regulation of dopamine uptake involved in synaptic transmission
is_a: GO:0051945 ! negative regulation of catecholamine uptake involved in synaptic transmission
is_a: GO:1903792 ! negative regulation of anion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051583 ! dopamine uptake involved in synaptic transmission
relationship: negatively_regulates GO:0051583 ! dopamine uptake involved in synaptic transmission

[Term]
id: GO:0051586
name: positive regulation of dopamine uptake involved in synaptic transmission
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of dopamine into a cell." [GOC:ai]
synonym: "activation of dopamine uptake involved in synaptic transmission" NARROW []
synonym: "positive regulation of dopamine import involved in synaptic transmission" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of dopamine uptake involved in synaptic transmission" NARROW []
synonym: "up regulation of dopamine uptake involved in synaptic transmission" EXACT []
synonym: "up-regulation of dopamine uptake involved in synaptic transmission" EXACT []
synonym: "upregulation of dopamine uptake involved in synaptic transmission" EXACT []
is_a: GO:0032226 ! positive regulation of synaptic transmission, dopaminergic
is_a: GO:0051584 ! regulation of dopamine uptake involved in synaptic transmission
is_a: GO:0051944 ! positive regulation of catecholamine uptake involved in synaptic transmission
is_a: GO:1903793 ! positive regulation of anion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051583 ! dopamine uptake involved in synaptic transmission
relationship: positively_regulates GO:0051583 ! dopamine uptake involved in synaptic transmission

[Term]
id: GO:0051587
name: inhibition of dopamine uptake involved in synaptic transmission
namespace: biological_process
def: "Any process that prevents the activation of the directed movement of dopamine into a cell." [GOC:ai]
synonym: "inhibition of dopamine import involved in synaptic transmission" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051585 ! negative regulation of dopamine uptake involved in synaptic transmission
is_a: GO:0051609 ! inhibition of neurotransmitter uptake

[Term]
id: GO:0051588
name: regulation of neurotransmitter transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006836 ! neurotransmitter transport
relationship: regulates GO:0006836 ! neurotransmitter transport

[Term]
id: GO:0051589
name: negative regulation of neurotransmitter transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "down regulation of neurotransmitter transport" EXACT []
synonym: "down-regulation of neurotransmitter transport" EXACT []
synonym: "downregulation of neurotransmitter transport" EXACT []
synonym: "inhibition of neurotransmitter transport" NARROW []
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:0051588 ! regulation of neurotransmitter transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006836 ! neurotransmitter transport
relationship: negatively_regulates GO:0006836 ! neurotransmitter transport

[Term]
id: GO:0051590
name: positive regulation of neurotransmitter transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "activation of neurotransmitter transport" NARROW []
synonym: "stimulation of neurotransmitter transport" NARROW []
synonym: "up regulation of neurotransmitter transport" EXACT []
synonym: "up-regulation of neurotransmitter transport" EXACT []
synonym: "upregulation of neurotransmitter transport" EXACT []
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:0051588 ! regulation of neurotransmitter transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006836 ! neurotransmitter transport
relationship: positively_regulates GO:0006836 ! neurotransmitter transport

[Term]
id: GO:0051591
name: response to cAMP
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus." [GOC:ai]
synonym: "response to 3',5' cAMP" EXACT []
synonym: "response to 3',5'-cAMP" EXACT []
synonym: "response to adenosine 3',5'-cyclophosphate" EXACT []
synonym: "response to cyclic AMP" EXACT []
is_a: GO:0014074 ! response to purine-containing compound
is_a: GO:0046683 ! response to organophosphorus
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0051592
name: response to calcium ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:ai]
synonym: "response to Ca2+ ion" EXACT []
is_a: GO:0010038 ! response to metal ion

[Term]
id: GO:0051593
name: response to folic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a folic acid stimulus." [GOC:ai]
synonym: "cellular response to folate" EXACT [GOC:mah]
synonym: "cellular response to vitamin B9" EXACT [GOC:mah]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033273 ! response to vitamin
is_a: GO:0043200 ! response to amino acid

[Term]
id: GO:0051594
name: detection of glucose
namespace: biological_process
def: "The series of events in which a glucose stimulus is received by a cell and converted into a molecular signal." [GOC:ai]
synonym: "glucose detection" EXACT []
synonym: "glucose perception" RELATED []
synonym: "glucose sensing" RELATED []
is_a: GO:0009732 ! detection of hexose stimulus
is_a: GO:0009749 ! response to glucose

[Term]
id: GO:0051595
name: response to methylglyoxal
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylglyoxal stimulus. Methylglyoxal is a 2-oxoaldehyde derived from propanal." [GOC:ai]
subset: gosubset_prok
synonym: "response to pyruvaldehyde" EXACT []
is_a: GO:1901654 ! response to ketone

[Term]
id: GO:0051596
name: methylglyoxal catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid." [GOC:ai]
subset: gosubset_prok
synonym: "methylglyoxal breakdown" EXACT []
synonym: "methylglyoxal catabolism" EXACT []
synonym: "methylglyoxal degradation" EXACT []
xref: MetaCyc:METHGLYUT-PWY
xref: MetaCyc:Methylglyoxal-Detoxification
is_a: GO:0009438 ! methylglyoxal metabolic process
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:0046185 ! aldehyde catabolic process

[Term]
id: GO:0051597
name: response to methylmercury
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylmercury stimulus." [GOC:ai]
synonym: "response to CH3-Hg+" EXACT []
synonym: "response to MeHg+" EXACT []
is_a: GO:0010033 ! response to organic substance
is_a: GO:1990267 ! response to transition metal nanoparticle

[Term]
id: GO:0051598
name: meiotic recombination checkpoint
namespace: biological_process
def: "A checkpoint that acts during late prophase I (pachytene) and prevents segregation of homologous chromosomes until recombination is completed, ensuring proper distribution of the genetic material to the gametes." [PMID:14718568]
synonym: "pachytene checkpoint" EXACT []
is_a: GO:0033313 ! meiotic cell cycle checkpoint
is_a: GO:0045835 ! negative regulation of meiotic nuclear division

[Term]
id: GO:0051599
name: response to hydrostatic pressure
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrostatic pressure stimulus. Hydrostatic pressure is the force acting on an object in a system where the fluid is at rest (as opposed to moving). The weight of the fluid above the object creates pressure on it." [Wikipedia:Hydrostatic_pressure]
synonym: "response to biomechanical stress" BROAD []
synonym: "response to static fluid pressure" EXACT []
is_a: GO:0006950 ! response to stress
is_a: GO:0009415 ! response to water

[Term]
id: GO:0051600
name: regulation of endocytosis by exocyst localization
namespace: biological_process
def: "Any process in which an exocyst is transported to, or maintained in, a specific location that results in the modulation of endocytosis. An exocyst is a protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse." [GOC:ai, GOC:dph, GOC:tb]
synonym: "regulation of endocytosis by exocyst localisation" EXACT [GOC:mah]
synonym: "regulation of site selection of endocytosis" RELATED []
synonym: "relocation of endocytosis" RELATED []
synonym: "spatial regulation of endocytosis" RELATED []
is_a: GO:0030100 ! regulation of endocytosis
is_a: GO:0051601 ! exocyst localization
intersection_of: GO:0051601 ! exocyst localization
intersection_of: regulates GO:0006897 ! endocytosis
relationship: regulates GO:0006897 ! endocytosis

[Term]
id: GO:0051601
name: exocyst localization
namespace: biological_process
def: "Any process in which an exocyst is transported to, or maintained in, a specific location. An exocyst is a protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse." [GOC:ai]
synonym: "establishment and maintenance of exocyst localization" EXACT []
synonym: "exocyst localisation" EXACT [GOC:mah]
is_a: GO:0034629 ! cellular protein complex localization

[Term]
id: GO:0051602
name: response to electrical stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus." [GOC:ai]
synonym: "response to electricity" RELATED []
is_a: GO:0009628 ! response to abiotic stimulus

[Term]
id: GO:0051603
name: proteolysis involved in cellular protein catabolic process
namespace: biological_process
def: "The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]
subset: goslim_yeast
subset: gosubset_prok
synonym: "peptidolysis during cellular protein catabolic process" RELATED []
synonym: "peptidolysis during cellular protein catabolism" RELATED []
synonym: "peptidolysis involved in cellular protein catabolic process" EXACT []
synonym: "peptidolysis involved in cellular protein catabolism" EXACT []
synonym: "proteolysis during cellular protein catabolic process" RELATED []
synonym: "proteolysis during cellular protein catabolism" RELATED []
is_a: GO:0006508 ! proteolysis
intersection_of: GO:0006508 ! proteolysis
intersection_of: part_of GO:0044257 ! cellular protein catabolic process
relationship: part_of GO:0044257 ! cellular protein catabolic process

[Term]
id: GO:0051604
name: protein maturation
namespace: biological_process
def: "Any process leading to the attainment of the full functional capacity of a protein." [GOC:ai]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_pir
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
is_a: GO:0019538 ! protein metabolic process
relationship: part_of GO:0010467 ! gene expression

[Term]
id: GO:0051606
name: detection of stimulus
namespace: biological_process
def: "The series of events in which a stimulus is received by a cell or organism and converted into a molecular signal." [GOC:add, GOC:ai, GOC:dph, GOC:mah]
subset: goslim_pir
subset: gosubset_prok
synonym: "perception of stimulus" RELATED []
synonym: "stimulus detection" EXACT []
synonym: "stimulus sensing" RELATED []
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0051607
name: defense response to virus
namespace: biological_process
def: "Reactions triggered in response to the presence of a virus that act to protect the cell or organism." [GOC:ai]
synonym: "antiviral response" EXACT []
synonym: "defence response to virus" EXACT []
synonym: "defense response to viruses" EXACT []
is_a: GO:0002252 ! immune effector process
is_a: GO:0009615 ! response to virus
is_a: GO:0098542 ! defense response to other organism

[Term]
id: GO:0051608
name: histamine transport
namespace: biological_process
def: "The directed movement of histamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:ai]
is_a: GO:0015696 ! ammonium transport
is_a: GO:0045117 ! azole transport

[Term]
id: GO:0051609
name: inhibition of neurotransmitter uptake
namespace: biological_process
def: "Any process that prevents the activation of the directed movement of a neurotransmitter into a cell." [GOC:ai]
synonym: "inhibition of neurotransmitter import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051581 ! negative regulation of neurotransmitter uptake

[Term]
id: GO:0051610
name: serotonin uptake
namespace: biological_process
def: "The directed movement of serotonin into a cell, typically presynaptic neurons or glial cells. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems." [GOC:ai]
synonym: "5-HT uptake" EXACT []
synonym: "5-hydroxytryptamine uptake" EXACT []
synonym: "5HT uptake" EXACT []
synonym: "serotonin import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0006837 ! serotonin transport
is_a: GO:0098810 ! neurotransmitter reuptake

[Term]
id: GO:0051611
name: regulation of serotonin uptake
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of the monoamine neurotransmitter serotonin into a cell." [GOC:ai]
synonym: "regulation of 5-HT uptake" EXACT []
synonym: "regulation of 5-hydroxytryptamine uptake" EXACT []
synonym: "regulation of 5HT uptake" EXACT []
synonym: "regulation of serotonin import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0044070 ! regulation of anion transport
is_a: GO:0051580 ! regulation of neurotransmitter uptake
is_a: GO:0060341 ! regulation of cellular localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051610 ! serotonin uptake
relationship: regulates GO:0051610 ! serotonin uptake

[Term]
id: GO:0051612
name: negative regulation of serotonin uptake
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of serotonin into a cell." [GOC:ai]
synonym: "down regulation of serotonin uptake" EXACT []
synonym: "down-regulation of serotonin uptake" EXACT []
synonym: "downregulation of serotonin uptake" EXACT []
synonym: "negative regulation of 5-HT uptake" EXACT []
synonym: "negative regulation of 5-hydroxytryptamine uptake" EXACT []
synonym: "negative regulation of 5HT uptake" EXACT []
synonym: "negative regulation of serotonin import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051581 ! negative regulation of neurotransmitter uptake
is_a: GO:0051611 ! regulation of serotonin uptake
is_a: GO:1903792 ! negative regulation of anion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051610 ! serotonin uptake
relationship: negatively_regulates GO:0051610 ! serotonin uptake

[Term]
id: GO:0051613
name: positive regulation of serotonin uptake
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of serotonin into a cell." [GOC:ai]
synonym: "activation of serotonin uptake" NARROW []
synonym: "positive regulation of 5-HT uptake" EXACT []
synonym: "positive regulation of 5-hydroxytryptamine uptake" EXACT []
synonym: "positive regulation of 5HT uptake" EXACT []
synonym: "positive regulation of serotonin import" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of serotonin uptake" NARROW []
synonym: "up regulation of serotonin uptake" EXACT []
synonym: "up-regulation of serotonin uptake" EXACT []
synonym: "upregulation of serotonin uptake" EXACT []
is_a: GO:0051582 ! positive regulation of neurotransmitter uptake
is_a: GO:0051611 ! regulation of serotonin uptake
is_a: GO:1903793 ! positive regulation of anion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051610 ! serotonin uptake
relationship: positively_regulates GO:0051610 ! serotonin uptake

[Term]
id: GO:0051614
name: inhibition of serotonin uptake
namespace: biological_process
def: "Any process that prevents the activation of the directed movement of serotonin into a cell." [GOC:ai]
synonym: "inhibition of 5-HT uptake" EXACT []
synonym: "inhibition of 5-hydroxytryptamine uptake" EXACT []
synonym: "inhibition of 5HT uptake" EXACT []
synonym: "inhibition of serotonin import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051609 ! inhibition of neurotransmitter uptake
is_a: GO:0051612 ! negative regulation of serotonin uptake

[Term]
id: GO:0051615
name: histamine uptake
namespace: biological_process
def: "The directed movement of histamine into a cell, typically presynaptic neurons or glial cells. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:ai]
synonym: "histamine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0001504 ! neurotransmitter uptake
is_a: GO:0051608 ! histamine transport

[Term]
id: GO:0051616
name: regulation of histamine uptake
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter histamine into a cell." [GOC:ai]
synonym: "regulation of histamine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0044070 ! regulation of anion transport
is_a: GO:0051580 ! regulation of neurotransmitter uptake
is_a: GO:2001023 ! regulation of response to drug
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051615 ! histamine uptake
relationship: regulates GO:0051615 ! histamine uptake

[Term]
id: GO:0051617
name: negative regulation of histamine uptake
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of histamine into a cell." [GOC:ai]
synonym: "down regulation of histamine uptake" EXACT []
synonym: "down-regulation of histamine uptake" EXACT []
synonym: "downregulation of histamine uptake" EXACT []
synonym: "negative regulation of histamine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051581 ! negative regulation of neurotransmitter uptake
is_a: GO:0051616 ! regulation of histamine uptake
is_a: GO:1903792 ! negative regulation of anion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051615 ! histamine uptake
relationship: negatively_regulates GO:0051615 ! histamine uptake

[Term]
id: GO:0051618
name: positive regulation of histamine uptake
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of histamine into a cell." [GOC:ai]
synonym: "activation of histamine uptake" NARROW []
synonym: "positive regulation of histamine import" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of histamine uptake" NARROW []
synonym: "up regulation of histamine uptake" EXACT []
synonym: "up-regulation of histamine uptake" EXACT []
synonym: "upregulation of histamine uptake" EXACT []
is_a: GO:0051582 ! positive regulation of neurotransmitter uptake
is_a: GO:0051616 ! regulation of histamine uptake
is_a: GO:1903793 ! positive regulation of anion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051615 ! histamine uptake
relationship: positively_regulates GO:0051615 ! histamine uptake

[Term]
id: GO:0051619
name: inhibition of histamine uptake
namespace: biological_process
def: "Any process that prevents the activation of the directed movement of histamine into a cell." [GOC:ai]
synonym: "inhibition of histamine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051609 ! inhibition of neurotransmitter uptake
is_a: GO:0051617 ! negative regulation of histamine uptake

[Term]
id: GO:0051620
name: norepinephrine uptake
namespace: biological_process
def: "The directed movement of norepinephrine into a cell, typically presynaptic neurons or glial cells. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine." [GOC:ai]
synonym: "levarterenol reuptake" EXACT []
synonym: "levarterenol uptake" EXACT []
synonym: "noradrenaline reuptake" EXACT []
synonym: "noradrenaline uptake" EXACT []
synonym: "norepinephrine import" EXACT [GOC:dph, GOC:tb]
synonym: "norepinephrine reuptake" EXACT []
is_a: GO:0015874 ! norepinephrine transport
is_a: GO:0090493 ! catecholamine uptake

[Term]
id: GO:0051621
name: regulation of norepinephrine uptake
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter norepinephrine into a cell." [GOC:ai]
synonym: "regulation of levarterenol uptake" EXACT []
synonym: "regulation of noradrenaline uptake" EXACT []
synonym: "regulation of norepinephrine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051940 ! regulation of catecholamine uptake involved in synaptic transmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051620 ! norepinephrine uptake
relationship: regulates GO:0051620 ! norepinephrine uptake

[Term]
id: GO:0051622
name: negative regulation of norepinephrine uptake
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of norepinephrine into a cell." [GOC:ai]
synonym: "down regulation of norepinephrine uptake" EXACT []
synonym: "down-regulation of norepinephrine uptake" EXACT []
synonym: "downregulation of norepinephrine uptake" EXACT []
synonym: "negative regulation of levarterenol uptake" EXACT []
synonym: "negative regulation of noradrenaline uptake" EXACT []
synonym: "negative regulation of norepinephrine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051621 ! regulation of norepinephrine uptake
is_a: GO:0051945 ! negative regulation of catecholamine uptake involved in synaptic transmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051620 ! norepinephrine uptake
relationship: negatively_regulates GO:0051620 ! norepinephrine uptake

[Term]
id: GO:0051623
name: positive regulation of norepinephrine uptake
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of norepinephrine into a cell." [GOC:ai]
synonym: "activation of norepinephrine uptake" NARROW []
synonym: "positive regulation of levarterenol uptake" EXACT []
synonym: "positive regulation of noradrenaline uptake" EXACT []
synonym: "positive regulation of norepinephrine import" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of norepinephrine uptake" NARROW []
synonym: "up regulation of norepinephrine uptake" EXACT []
synonym: "up-regulation of norepinephrine uptake" EXACT []
synonym: "upregulation of norepinephrine uptake" EXACT []
is_a: GO:0051621 ! regulation of norepinephrine uptake
is_a: GO:0051944 ! positive regulation of catecholamine uptake involved in synaptic transmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051620 ! norepinephrine uptake
relationship: positively_regulates GO:0051620 ! norepinephrine uptake

[Term]
id: GO:0051624
name: inhibition of norepinephrine uptake
namespace: biological_process
def: "Any process that prevents the activation of the directed movement of norepinephrine into a cell." [GOC:ai]
synonym: "inhibition of levarterenol uptake" EXACT []
synonym: "inhibition of noradrenaline uptake" EXACT []
synonym: "inhibition of norepinephrine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051609 ! inhibition of neurotransmitter uptake
is_a: GO:0051622 ! negative regulation of norepinephrine uptake

[Term]
id: GO:0051625
name: epinephrine uptake
namespace: biological_process
def: "The directed movement of epinephrine into a cell, typically presynaptic neurons or glial cells. Epinephrine is a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine." [GOC:ai]
synonym: "adrenaline reuptake" EXACT []
synonym: "adrenaline uptake" EXACT []
synonym: "epinephrine import" EXACT [GOC:dph, GOC:tb]
synonym: "epinephrine reuptake" EXACT []
is_a: GO:0048241 ! epinephrine transport
is_a: GO:0090493 ! catecholamine uptake

[Term]
id: GO:0051626
name: regulation of epinephrine uptake
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter epinephrine into a cell." [GOC:ai]
synonym: "regulation of adrenaline uptake" EXACT []
synonym: "regulation of epinephrine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010817 ! regulation of hormone levels
is_a: GO:0051940 ! regulation of catecholamine uptake involved in synaptic transmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051625 ! epinephrine uptake
relationship: regulates GO:0051625 ! epinephrine uptake

[Term]
id: GO:0051627
name: negative regulation of epinephrine uptake
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of epinephrine into a cell." [GOC:ai]
synonym: "down regulation of epinephrine uptake" EXACT []
synonym: "down-regulation of epinephrine uptake" EXACT []
synonym: "downregulation of epinephrine uptake" EXACT []
synonym: "negative regulation of adrenaline uptake" EXACT []
synonym: "negative regulation of epinephrine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051626 ! regulation of epinephrine uptake
is_a: GO:0051945 ! negative regulation of catecholamine uptake involved in synaptic transmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051625 ! epinephrine uptake
relationship: negatively_regulates GO:0051625 ! epinephrine uptake

[Term]
id: GO:0051628
name: positive regulation of epinephrine uptake
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of epinephrine into a cell." [GOC:ai]
synonym: "activation of epinephrine uptake" NARROW []
synonym: "positive regulation of adrenaline uptake" EXACT []
synonym: "positive regulation of epinephrine import" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of epinephrine uptake" NARROW []
synonym: "up regulation of epinephrine uptake" EXACT []
synonym: "up-regulation of epinephrine uptake" EXACT []
synonym: "upregulation of epinephrine uptake" EXACT []
is_a: GO:0051626 ! regulation of epinephrine uptake
is_a: GO:0051944 ! positive regulation of catecholamine uptake involved in synaptic transmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051625 ! epinephrine uptake
relationship: positively_regulates GO:0051625 ! epinephrine uptake

[Term]
id: GO:0051629
name: inhibition of epinephrine uptake
namespace: biological_process
def: "Any process that prevents the activation of the directed movement of epinephrine into a cell." [GOC:ai]
synonym: "inhibition of adrenaline uptake" EXACT []
synonym: "inhibition of epinephrine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051609 ! inhibition of neurotransmitter uptake
is_a: GO:0051627 ! negative regulation of epinephrine uptake

[Term]
id: GO:0051630
name: acetylcholine uptake
namespace: biological_process
def: "The directed movement of acetylcholine into a cell, typically presynaptic neurons or glial cells. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:ai]
synonym: "acetylcholine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0001504 ! neurotransmitter uptake
is_a: GO:0015870 ! acetylcholine transport

[Term]
id: GO:0051631
name: regulation of acetylcholine uptake
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter acetylcholine into a cell." [GOC:ai]
synonym: "regulation of acetylcholine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0044070 ! regulation of anion transport
is_a: GO:0051580 ! regulation of neurotransmitter uptake
is_a: GO:0051952 ! regulation of amine transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051630 ! acetylcholine uptake
relationship: regulates GO:0051630 ! acetylcholine uptake

[Term]
id: GO:0051632
name: negative regulation of acetylcholine uptake
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of acetylcholine into a cell." [GOC:ai]
synonym: "down regulation of acetylcholine uptake" EXACT []
synonym: "down-regulation of acetylcholine uptake" EXACT []
synonym: "downregulation of acetylcholine uptake" EXACT []
synonym: "negative regulation of acetylcholine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051581 ! negative regulation of neurotransmitter uptake
is_a: GO:0051631 ! regulation of acetylcholine uptake
is_a: GO:0051953 ! negative regulation of amine transport
is_a: GO:1903792 ! negative regulation of anion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051630 ! acetylcholine uptake
relationship: negatively_regulates GO:0051630 ! acetylcholine uptake

[Term]
id: GO:0051633
name: positive regulation of acetylcholine uptake
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of acetylcholine into a cell." [GOC:ai]
synonym: "activation of acetylcholine uptake" NARROW []
synonym: "positive regulation of acetylcholine import" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of acetylcholine uptake" NARROW []
synonym: "up regulation of acetylcholine uptake" EXACT []
synonym: "up-regulation of acetylcholine uptake" EXACT []
synonym: "upregulation of acetylcholine uptake" EXACT []
is_a: GO:0051582 ! positive regulation of neurotransmitter uptake
is_a: GO:0051631 ! regulation of acetylcholine uptake
is_a: GO:0051954 ! positive regulation of amine transport
is_a: GO:1903793 ! positive regulation of anion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051630 ! acetylcholine uptake
relationship: positively_regulates GO:0051630 ! acetylcholine uptake

[Term]
id: GO:0051634
name: inhibition of acetylcholine uptake
namespace: biological_process
def: "Any process that prevents the activation of the directed movement of acetylcholine into a cell." [GOC:ai]
synonym: "inhibition of acetylcholine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051609 ! inhibition of neurotransmitter uptake
is_a: GO:0051632 ! negative regulation of acetylcholine uptake

[Term]
id: GO:0051635
name: obsolete bacterial cell surface binding
namespace: molecular_function
alt_id: GO:0008367
def: "OBSOLETE. Interacting selectively and non-covalently with any component on the surface of a bacterial cell." [GOC:ai]
comment: This term was made obsolete because it is ambiguous and causing confusion, and is an unnecessary grouping term.
subset: gosubset_prok
synonym: "bacterial binding" EXACT []
synonym: "bacterial cell surface binding" EXACT []
synonym: "bacterium binding" EXACT []
synonym: "bacterium cell surface binding" EXACT []
synonym: "binding to bacterium" EXACT []
is_obsolete: true
consider: GO:0003823
consider: GO:0005102
consider: GO:0042742

[Term]
id: GO:0051636
name: obsolete Gram-negative bacterial cell surface binding
namespace: molecular_function
alt_id: GO:0008368
def: "OBSOLETE. Interacting selectively and non-covalently with any component on the surface of a Gram-negative bacterial cell." [GOC:ai]
comment: This term was made obsolete because it is an unnecessary grouping term and was causing confusion.
subset: gosubset_prok
synonym: "binding to Gram-negative bacterium" EXACT []
synonym: "Gram-negative bacterial binding" EXACT []
synonym: "Gram-negative bacterial cell surface binding" EXACT []
synonym: "Gram-negative bacterium binding" EXACT []
synonym: "Gram-negative bacterium cell surface binding" EXACT []
is_obsolete: true
consider: GO:0003823
consider: GO:0050829

[Term]
id: GO:0051637
name: obsolete Gram-positive bacterial cell surface binding
namespace: molecular_function
alt_id: GO:0051076
def: "OBSOLETE. Interacting selectively and non-covalently with any component on the surface of a Gram-positive bacterium." [GOC:ai]
comment: This term was made obsolete because it is an unnecessary grouping term and was causing confusion.
subset: gosubset_prok
synonym: "binding to Gram-positive bacterium" EXACT []
synonym: "Gram-positive bacterial binding" EXACT []
synonym: "Gram-positive bacterial cell surface binding" EXACT []
synonym: "Gram-positive bacterium binding" EXACT []
synonym: "Gram-positive bacterium cell surface binding" EXACT []
is_obsolete: true
consider: GO:0003823
consider: GO:0050830

[Term]
id: GO:0051638
name: barbed-end actin filament uncapping
namespace: biological_process
def: "The removal of capping protein from the barbed (or plus) end of actin filaments to free the ends for addition, exchange or removal of further actin subunits." [GOC:pf]
synonym: "barbed end actin filament uncapping" EXACT []
synonym: "barbed end F-actin uncapping" EXACT []
synonym: "barbed-end F-actin uncapping" EXACT []
synonym: "plus end actin filament uncapping" EXACT []
synonym: "plus end F-actin uncapping" EXACT []
synonym: "plus-end actin filament uncapping" EXACT []
synonym: "plus-end F-actin uncapping" EXACT []
is_a: GO:0051695 ! actin filament uncapping

[Term]
id: GO:0051639
name: actin filament network formation
namespace: biological_process
def: "The assembly of a network of actin filaments; actin filaments on different axes and with differing orientations are crosslinked together to form a mesh of filaments." [GOC:ai]
synonym: "actin gel biosynthesis" EXACT []
synonym: "actin gel formation" EXACT []
is_a: GO:0007015 ! actin filament organization

[Term]
id: GO:0051640
name: organelle localization
namespace: biological_process
def: "Any process in which an organelle is transported to, and/or maintained in, a specific location." [GOC:ai]
subset: goslim_pir
synonym: "establishment and maintenance of organelle localization" EXACT []
synonym: "organelle localisation" EXACT [GOC:mah]
is_a: GO:0051641 ! cellular localization

[Term]
id: GO:0051641
name: cellular localization
namespace: biological_process
def: "A localization process that takes place at the cellular level; as a result of a cellular localization process, a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within or in the membrane of a cell." [GOC:ai, GOC:mah]
subset: goslim_pir
subset: gosubset_prok
synonym: "cellular localisation" EXACT [GOC:mah]
synonym: "establishment and maintenance of cellular localization" EXACT []
synonym: "establishment and maintenance of localization in cell or cell membrane" EXACT []
synonym: "intracellular localization" NARROW []
synonym: "localization within cell" NARROW []
is_a: GO:0051179 ! localization

[Term]
id: GO:0051642
name: centrosome localization
namespace: biological_process
def: "Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell." [GOC:ai]
synonym: "centrosome localisation" EXACT [GOC:mah]
synonym: "establishment and maintenance of centrosome localization" EXACT []
is_a: GO:0051640 ! organelle localization

[Term]
id: GO:0051643
name: endoplasmic reticulum localization
namespace: biological_process
def: "Any process in which endoplasmic reticulum is transported to, and/or maintained in, a specific location within the cell." [GOC:ai]
synonym: "endoplasmic reticulum localisation" EXACT [GOC:mah]
synonym: "ER localization" EXACT [GOC:dph]
synonym: "establishment and maintenance of ER localization" EXACT []
is_a: GO:0051640 ! organelle localization

[Term]
id: GO:0051644
name: plastid localization
namespace: biological_process
def: "Any process in which a plastid is transported to, and/or maintained in, a specific location within the cell." [GOC:ai]
synonym: "establishment and maintenance of plastid localization" EXACT []
synonym: "plastid localisation" EXACT [GOC:mah]
is_a: GO:0051640 ! organelle localization

[Term]
id: GO:0051645
name: Golgi localization
namespace: biological_process
def: "Any process in which the Golgi is transported to, and/or maintained in, a specific location within the cell." [GOC:ai]
synonym: "establishment and maintenance of Golgi localization" EXACT []
synonym: "Golgi apparatus localization" EXACT []
synonym: "Golgi body localization" EXACT []
synonym: "Golgi localisation" EXACT [GOC:mah]
is_a: GO:0051640 ! organelle localization

[Term]
id: GO:0051646
name: mitochondrion localization
namespace: biological_process
def: "Any process in which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell." [GOC:ai]
synonym: "establishment and maintenance of mitochondria localization" EXACT []
synonym: "establishment and maintenance of mitochondrion localization" EXACT []
synonym: "localization of mitochondria" EXACT []
synonym: "localization of mitochondrion" EXACT []
synonym: "mitochondria localization" EXACT []
synonym: "mitochondrial localization" EXACT []
synonym: "mitochondrion localisation" EXACT [GOC:mah]
is_a: GO:0051640 ! organelle localization

[Term]
id: GO:0051647
name: nucleus localization
namespace: biological_process
def: "Any process in which the nucleus is transported to, and/or maintained in, a specific location within the cell." [GOC:ai]
synonym: "cell nucleus localization" EXACT []
synonym: "establishment and maintenance of nucleus localization" EXACT []
synonym: "localization of nucleus" EXACT []
synonym: "nucleus localisation" EXACT [GOC:mah]
is_a: GO:0051640 ! organelle localization

[Term]
id: GO:0051648
name: vesicle localization
namespace: biological_process
def: "Any process in which a vesicle or vesicles are transported to, and/or maintained in, a specific location." [GOC:ai]
synonym: "cytoplasmic vesicle localization" EXACT []
synonym: "establishment and maintenance of vesicle localization" EXACT []
synonym: "vesicle localisation" EXACT [GOC:mah]
is_a: GO:0051640 ! organelle localization

[Term]
id: GO:0051649
name: establishment of localization in cell
namespace: biological_process
def: "The directed movement of a substance or cellular entity, such as a protein complex or organelle, to a specific location within, or in the membrane of, a cell." [GOC:ai, GOC:dph, GOC:tb]
subset: gosubset_prok
synonym: "establishment of cellular localization" RELATED [GOC:dph, GOC:tb]
synonym: "establishment of intracellular localization" NARROW []
synonym: "establishment of localisation in cell" EXACT [GOC:mah]
synonym: "establishment of localization within cell" NARROW []
synonym: "positioning within cell" NARROW []
is_a: GO:0051234 ! establishment of localization
intersection_of: GO:0051234 ! establishment of localization
intersection_of: occurs_in GO:0005623 ! cell
relationship: occurs_in GO:0005623 ! cell
relationship: part_of GO:0051641 ! cellular localization

[Term]
id: GO:0051650
name: establishment of vesicle localization
namespace: biological_process
def: "The directed movement of a vesicle to a specific location." [GOC:ai]
subset: goslim_aspergillus
synonym: "establishment of vesicle localisation" EXACT [GOC:mah]
is_a: GO:0051648 ! vesicle localization
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0051656 ! establishment of organelle localization

[Term]
id: GO:0051651
name: maintenance of location in cell
namespace: biological_process
def: "Any process in which a substance or cellular entity, such as a protein complex or organelle, is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere." [GOC:ai]
subset: gosubset_prok
synonym: "cellular retention" NARROW []
synonym: "cellular sequestering" NARROW []
synonym: "cellular storage" NARROW []
synonym: "intracellular retention" NARROW []
synonym: "intracellular sequestering" NARROW []
synonym: "intracellular storage" NARROW []
synonym: "maintenance of cellular localization" RELATED [GOC:dph, GOC:tb]
synonym: "maintenance of intracellular localization" NARROW []
synonym: "maintenance of localization in cell" RELATED [GOC:dph, GOC:tb]
synonym: "maintenance of localization within cell" NARROW []
synonym: "retention within cell" NARROW []
synonym: "sequestering within cell" NARROW []
synonym: "storage within cell" NARROW []
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0051235 ! maintenance of location
is_a: GO:1902578 ! single-organism localization
relationship: part_of GO:0051641 ! cellular localization

[Term]
id: GO:0051652
name: maintenance of chromosome location
namespace: biological_process
def: "Any process in which a chromosome is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb]
synonym: "maintenance of chromosome localization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0050000 ! chromosome localization
is_a: GO:0051657 ! maintenance of organelle location
is_a: GO:1902580 ! single-organism cellular localization

[Term]
id: GO:0051653
name: spindle localization
namespace: biological_process
def: "Any process in which is the spindle is transported to, and/or maintained in, a specific location." [GOC:ai]
synonym: "establishment and maintenance of spindle localization" EXACT []
synonym: "spindle localisation" EXACT [GOC:mah]
is_a: GO:0022402 ! cell cycle process
is_a: GO:0051640 ! organelle localization
is_a: GO:1902580 ! single-organism cellular localization

[Term]
id: GO:0051654
name: establishment of mitochondrion localization
namespace: biological_process
def: "The directed movement of the mitochondrion to a specific location." [GOC:ai]
synonym: "establishment of mitochondria localization" EXACT []
synonym: "establishment of mitochondrion localisation" EXACT [GOC:mah]
synonym: "mitochondria positioning" EXACT []
synonym: "mitochondrial migration" EXACT []
synonym: "mitochondrion positioning" EXACT []
is_a: GO:0051646 ! mitochondrion localization
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0051656 ! establishment of organelle localization

[Term]
id: GO:0051655
name: maintenance of vesicle location
namespace: biological_process
def: "Any process in which a vesicle is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb]
synonym: "maintenance of vesicle localization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051648 ! vesicle localization
is_a: GO:0051657 ! maintenance of organelle location
is_a: GO:1902580 ! single-organism cellular localization

[Term]
id: GO:0051656
name: establishment of organelle localization
namespace: biological_process
def: "The directed movement of an organelle to a specific location." [GOC:ai]
synonym: "establishment of organelle localisation" EXACT [GOC:mah]
is_a: GO:0051234 ! establishment of localization
is_a: GO:0051640 ! organelle localization

[Term]
id: GO:0051657
name: maintenance of organelle location
namespace: biological_process
def: "Any process in which an organelle is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb]
synonym: "maintenance of organelle localization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051651 ! maintenance of location in cell
relationship: part_of GO:0051640 ! organelle localization

[Term]
id: GO:0051658
name: maintenance of nucleus location
namespace: biological_process
def: "Any process in which the nucleus is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb]
synonym: "maintenance of cell nucleus location" EXACT []
synonym: "maintenance of nucleus localization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051647 ! nucleus localization
is_a: GO:0051657 ! maintenance of organelle location
is_a: GO:1902580 ! single-organism cellular localization

[Term]
id: GO:0051659
name: maintenance of mitochondrion location
namespace: biological_process
def: "Any process in which a mitochondrion is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb]
synonym: "maintenance of mitochondria localization" EXACT []
synonym: "maintenance of mitochondrion localization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051646 ! mitochondrion localization
is_a: GO:0051657 ! maintenance of organelle location
is_a: GO:1902580 ! single-organism cellular localization

[Term]
id: GO:0051660
name: establishment of centrosome localization
namespace: biological_process
def: "The directed movement of the centrosome to a specific location." [GOC:ai]
synonym: "centrosome positioning" EXACT []
synonym: "establishment of centrosome localisation" EXACT [GOC:mah]
is_a: GO:0051642 ! centrosome localization
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0051656 ! establishment of organelle localization

[Term]
id: GO:0051661
name: maintenance of centrosome location
namespace: biological_process
def: "Any process in which a centrosome is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb]
synonym: "maintenance of centrosome localization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051642 ! centrosome localization
is_a: GO:0051657 ! maintenance of organelle location
is_a: GO:1902580 ! single-organism cellular localization

[Term]
id: GO:0051663
name: oocyte nucleus localization involved in oocyte dorsal/ventral axis specification
namespace: biological_process
alt_id: GO:0051662
def: "The directed movement of the nucleus to a specific location within a cell during the establishment and maintenance of the dorsal/ventral axis of the oocyte." [GOC:ai, GOC:dph, GOC:mtg_sensu, GOC:tb]
synonym: "establishment and maintenance of oocyte nucleus localization during oocyte axis determination" EXACT []
synonym: "oocyte axis determination, oocyte nucleus localization" EXACT []
synonym: "oocyte nucleus localisation involved in oocyte dorsal/ventral axis specification" EXACT [GOC:mah]
synonym: "oocyte nucleus localization during oocyte axis determination" RELATED [GOC:dph, GOC:tb]
synonym: "oocyte nucleus localization involved in oocyte dorsal-ventral axis specification" EXACT [GOC:mah]
synonym: "oocyte nucleus localization involved in oocyte dorsal/ventral axis determination" EXACT [GOC:dph, GOC:tb]
synonym: "oocyte nucleus localization involved in oocyte dorsoventral axis specification" EXACT [GOC:mah]
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0051647 ! nucleus localization
is_a: GO:1902580 ! single-organism cellular localization
relationship: part_of GO:0007310 ! oocyte dorsal/ventral axis specification

[Term]
id: GO:0051664
name: nuclear pore localization
namespace: biological_process
def: "Any process in which nuclear pores are transported to, or maintained in, a specific location." [GOC:ai]
synonym: "establishment and maintenance of nuclear pore localization" EXACT []
synonym: "nuclear pore localisation" EXACT [GOC:mah]
is_a: GO:0034629 ! cellular protein complex localization
is_a: GO:0051668 ! localization within membrane

[Term]
id: GO:0051665
name: membrane raft localization
namespace: biological_process
def: "Any process in which membrane rafts are transported to, or maintained in, a specific location. Membrane rafts are small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes." [GOC:ai, PMID:16645198]
synonym: "establishment and maintenance of membrane raft localization" EXACT []
synonym: "lipid raft localization" EXACT []
synonym: "membrane raft localisation" EXACT [GOC:mah]
is_a: GO:0051668 ! localization within membrane

[Term]
id: GO:0051666
name: actin cortical patch localization
namespace: biological_process
def: "Any process in which actin cortical patches are transported to, or maintained in, a specific location. An actin cortical patch is a discrete actin-containing structure found just beneath the plasma membrane in fungal cells." [GOC:mah]
synonym: "actin cortical patch localisation" EXACT [GOC:mah]
synonym: "establishment and maintenance of actin cortical patch localization" EXACT []
is_a: GO:0051641 ! cellular localization

[Term]
id: GO:0051667
name: establishment of plastid localization
namespace: biological_process
def: "The directed movement of a plastid to a specific location in the cell." [GOC:ai]
synonym: "establishment of plastid localisation" EXACT [GOC:mah]
is_a: GO:0051644 ! plastid localization
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0051656 ! establishment of organelle localization

[Term]
id: GO:0051668
name: localization within membrane
namespace: biological_process
def: "Any process in which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a membrane." [GOC:ai]
subset: gosubset_prok
synonym: "establishment and maintenance of localization in membrane" EXACT []
synonym: "establishment and maintenance of position in membrane" EXACT []
synonym: "localisation within membrane" EXACT [GOC:mah]
synonym: "localization to membrane" EXACT []
synonym: "positioning within membrane" NARROW []
is_a: GO:0051641 ! cellular localization
intersection_of: GO:0051179 ! localization
intersection_of: occurs_in GO:0016020 ! membrane
relationship: occurs_in GO:0016020 ! membrane

[Term]
id: GO:0051669
name: fructan beta-fructosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal, non-reducing 2,1- and 2,6-linked beta-D-fructofuranose residues in fructans." [EC:3.2.1.80]
synonym: "beta-D-fructan fructohydrolase activity" EXACT [EC:3.2.1.80]
synonym: "exo-beta-D-fructosidase activity" EXACT []
synonym: "exo-beta-fructosidase activity" EXACT []
synonym: "fructan b-fructosidase activity" EXACT []
synonym: "fructan exohydrolase activity" EXACT []
synonym: "fructanase activity" EXACT [EC:3.2.1.80]
synonym: "polysaccharide beta-fructofuranosidase activity" EXACT []
xref: EC:3.2.1.80
xref: MetaCyc:3.2.1.80-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0051670
name: inulinase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of 2,1-beta-D-fructosidic linkages in inulin." [EC:3.2.1.7]
synonym: "2,1-beta-D-fructan fructanohydrolase activity" EXACT []
synonym: "endo-inulinase activity" EXACT []
synonym: "exoinulinase activity" EXACT []
synonym: "indoinulinase activity" EXACT []
synonym: "inulase activity" EXACT []
xref: EC:3.2.1.7
xref: MetaCyc:3.2.1.7-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0051671
name: induction of autolysin activity in other organism
namespace: biological_process
def: "Any process in which an organism initiates the activity of the inactive enzyme autolysin in another organism. The autolysin enzyme belongs to, and is active in, the other organism." [GOC:ai]
subset: gosubset_prok
synonym: "activation of autolysin activity in another organism" EXACT []
synonym: "activation of autolysis in other organism" NARROW []
synonym: "activation of autolytic activity in other organism" NARROW []
synonym: "induction of autolysin activity in another organism" EXACT [GOC:bf]
synonym: "induction of autolysis in other organism" NARROW []
synonym: "induction of autolytic activity in other organism" NARROW []
synonym: "positive regulation of autolysin activity in another organism" BROAD []
is_a: GO:0043946 ! positive regulation of catalytic activity in other organism involved in symbiotic interaction

[Term]
id: GO:0051672
name: catabolism by organism of cell wall peptidoglycan in other organism
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the cell wall peptidoglycans of another organism." [GOC:ai]
subset: gosubset_prok
synonym: "catabolic process of cell wall peptidoglycans of other organism" EXACT []
synonym: "catabolism of cell wall peptidoglycans of other organism" EXACT []
synonym: "cell wall catabolic process in other organism" NARROW []
synonym: "cell wall catabolism in other organism" NARROW []
synonym: "cell wall peptidoglycan catabolic process in another organism" EXACT []
is_a: GO:0009253 ! peptidoglycan catabolic process
is_a: GO:0044041 ! multi-organism carbohydrate catabolic process
relationship: part_of GO:0009617 ! response to bacterium
relationship: part_of GO:0044278 ! cell wall disruption in other organism

[Term]
id: GO:0051673
name: membrane disruption in other organism
namespace: biological_process
def: "The disruption of the membranes of another organism, leading to damage to its cells and possibly death of that organism." [GOC:ai]
subset: gosubset_prok
synonym: "cytolysis, by membrane disruption, in other organism" NARROW []
synonym: "membrane disruption in another organism" EXACT [GOC:bf]
is_a: GO:0035821 ! modification of morphology or physiology of other organism

[Term]
id: GO:0051674
name: localization of cell
namespace: biological_process
def: "Any process in which a cell is transported to, and/or maintained in, a specific location." [GOC:ai]
subset: gosubset_prok
synonym: "cell localization" EXACT []
synonym: "establishment and maintenance of cell localization" EXACT []
synonym: "establishment and maintenance of localization of cell" EXACT []
synonym: "localisation of cell" EXACT [GOC:mah]
is_a: GO:0051179 ! localization

[Term]
id: GO:0051675
name: isopullulanase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of pullulan to isopanose (6-alpha-maltosylglucose)." [EC:3.2.1.57]
synonym: "pullulan 4-glucanohydrolase (isopanose-forming) activity" EXACT []
xref: EC:3.2.1.57
xref: MetaCyc:3.2.1.57-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0051676
name: pullulan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pullulan, a neutral linear polysaccharide composed of repeating units of maltotriose joined by alpha-(1,6)-linkages." [PMID:15013381]
synonym: "pullulan metabolism" EXACT []
is_a: GO:0006073 ! cellular glucan metabolic process

[Term]
id: GO:0051677
name: pullulan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pullulan, a neutral linear polysaccharide composed of repeating units of maltotriose joined by alpha-(1,6)-linkages." [GOC:ai]
is_a: GO:0009250 ! glucan biosynthetic process
is_a: GO:0051676 ! pullulan metabolic process

[Term]
id: GO:0051678
name: pullulan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pullulan, a neutral linear polysaccharide composed of repeating units of maltotriose joined by alpha-(1,6)-linkages." [GOC:ai]
is_a: GO:0009251 ! glucan catabolic process
is_a: GO:0044247 ! cellular polysaccharide catabolic process
is_a: GO:0051676 ! pullulan metabolic process

[Term]
id: GO:0051679
name: 6-alpha-maltosylglucose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 6-alpha-maltosylglucose, also known as isopanose." [GOC:ai, LIGAND:C03367, PubChem_Compound:439991]
synonym: "6-alpha-maltosylglucose metabolism" EXACT []
synonym: "isopanose metabolic process" EXACT []
synonym: "isopanose metabolism" EXACT []
is_a: GO:0009311 ! oligosaccharide metabolic process
is_a: GO:0044264 ! cellular polysaccharide metabolic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0051680
name: 6-alpha-maltosylglucose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 6-alpha-maltosylglucose, also known as isopanose." [GOC:ai]
synonym: "isopanose biosynthesis" EXACT []
synonym: "isopanose biosynthetic process" EXACT []
is_a: GO:0009312 ! oligosaccharide biosynthetic process
is_a: GO:0033692 ! cellular polysaccharide biosynthetic process
is_a: GO:0051679 ! 6-alpha-maltosylglucose metabolic process

[Term]
id: GO:0051681
name: 6-alpha-maltosylglucose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 6-alpha-maltosylglucose, also known as isopanose." [GOC:ai]
synonym: "isopanose catabolic process" EXACT []
synonym: "isopanose catabolism" EXACT []
is_a: GO:0009313 ! oligosaccharide catabolic process
is_a: GO:0044247 ! cellular polysaccharide catabolic process
is_a: GO:0051679 ! 6-alpha-maltosylglucose metabolic process

[Term]
id: GO:0051682
name: galactomannan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of galactomannan, a polysaccharide composed of D-galactosyl and D-mannosyl. The mannosyl units form the backbone structure (a linear main chain) with the D-galactosyl as single side units." [GOC:ai]
is_a: GO:0000272 ! polysaccharide catabolic process
is_a: GO:0051069 ! galactomannan metabolic process

[Term]
id: GO:0051683
name: establishment of Golgi localization
namespace: biological_process
def: "The directed movement of the Golgi to a specific location." [GOC:ai]
synonym: "establishment of Golgi apparatus localization" EXACT []
synonym: "establishment of Golgi body localization" EXACT []
synonym: "establishment of Golgi localisation" EXACT [GOC:mah]
is_a: GO:0051645 ! Golgi localization
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0051656 ! establishment of organelle localization

[Term]
id: GO:0051684
name: maintenance of Golgi location
namespace: biological_process
def: "Any process in which the Golgi is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb]
synonym: "maintenance of Golgi apparatus localization" EXACT []
synonym: "maintenance of Golgi body localization" EXACT []
synonym: "maintenance of Golgi localization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051645 ! Golgi localization
is_a: GO:0051657 ! maintenance of organelle location
is_a: GO:1902580 ! single-organism cellular localization

[Term]
id: GO:0051685
name: maintenance of ER location
namespace: biological_process
def: "Any process in which the endoplasmic reticulum is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb]
synonym: "maintenance of endoplasmic reticulum localization" EXACT []
synonym: "maintenance of ER localization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051643 ! endoplasmic reticulum localization
is_a: GO:0051657 ! maintenance of organelle location
is_a: GO:1902580 ! single-organism cellular localization

[Term]
id: GO:0051686
name: establishment of ER localization
namespace: biological_process
def: "The directed movement of the endoplasmic reticulum to a specific location." [GOC:ai]
synonym: "establishment of endoplasmic reticulum localization" EXACT []
synonym: "establishment of ER localisation" EXACT [GOC:mah]
is_a: GO:0051643 ! endoplasmic reticulum localization
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0051656 ! establishment of organelle localization

[Term]
id: GO:0051687
name: maintenance of spindle location
namespace: biological_process
def: "Any process in which the spindle is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb]
synonym: "maintenance of spindle localization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051653 ! spindle localization
is_a: GO:0051657 ! maintenance of organelle location

[Term]
id: GO:0051688
name: maintenance of plastid location
namespace: biological_process
def: "Any process in which a plastid is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb]
synonym: "maintenance of plastid localization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051644 ! plastid localization
is_a: GO:0051657 ! maintenance of organelle location
is_a: GO:1902580 ! single-organism cellular localization

[Term]
id: GO:0051689
name: multicellular organismal oligosaccharide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages, in multicellular organisms, occurring at the tissue, organ, or organismal level." [GOC:ai]
synonym: "organismal oligosaccharide breakdown" EXACT []
synonym: "organismal oligosaccharide catabolism" EXACT []
synonym: "organismal oligosaccharide degradation" EXACT []
is_a: GO:0009313 ! oligosaccharide catabolic process
is_a: GO:0044276 ! multicellular organism carbohydrate catabolic process
is_a: GO:0051690 ! multicellular organismal oligosaccharide metabolic process

[Term]
id: GO:0051690
name: multicellular organismal oligosaccharide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages, in multicellular organisms, occurring at the tissue, organ, or organismal level." [GOC:ai]
synonym: "organismal oligosaccharide metabolism" EXACT []
is_a: GO:0009311 ! oligosaccharide metabolic process
is_a: GO:0044261 ! multicellular organism carbohydrate metabolic process

[Term]
id: GO:0051691
name: cellular oligosaccharide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages, as carried out by individual cells." [GOC:ai]
synonym: "cellular oligosaccharide metabolism" EXACT []
is_a: GO:0009311 ! oligosaccharide metabolic process
is_a: GO:0044262 ! cellular carbohydrate metabolic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0051692
name: cellular oligosaccharide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages, as carried out by individual cells." [GOC:ai]
synonym: "cellular oligosaccharide breakdown" EXACT []
synonym: "cellular oligosaccharide catabolism" EXACT []
synonym: "cellular oligosaccharide degradation" EXACT []
is_a: GO:0009313 ! oligosaccharide catabolic process
is_a: GO:0044275 ! cellular carbohydrate catabolic process
is_a: GO:0051691 ! cellular oligosaccharide metabolic process

[Term]
id: GO:0051693
name: actin filament capping
namespace: biological_process
def: "The binding of a protein or protein complex to the end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X]
synonym: "actin capping activity" RELATED []
synonym: "F-actin capping activity" RELATED []
is_a: GO:0030835 ! negative regulation of actin filament depolymerization
is_a: GO:0030837 ! negative regulation of actin filament polymerization

[Term]
id: GO:0051694
name: pointed-end actin filament capping
namespace: biological_process
def: "The binding of a protein or protein complex to the pointed (or minus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X]
synonym: "minus-end actin filament capping activity" EXACT []
synonym: "minus-end F-actin capping activity" EXACT []
synonym: "pointed-end actin capping activity" EXACT []
synonym: "pointed-end F-actin capping activity" EXACT []
is_a: GO:0051693 ! actin filament capping

[Term]
id: GO:0051695
name: actin filament uncapping
namespace: biological_process
def: "The removal of capping protein from the end of actin filaments to free the ends for addition, exchange or removal of further actin subunits." [GOC:pf]
synonym: "F-actin uncapping" EXACT []
is_a: GO:0030836 ! positive regulation of actin filament depolymerization

[Term]
id: GO:0051696
name: pointed-end actin filament uncapping
namespace: biological_process
def: "The removal of capping protein from the pointed (or minus) end of actin filaments to free the ends for addition, exchange or removal of further actin subunits." [GOC:pf]
synonym: "minus end actin filament uncapping" EXACT []
synonym: "minus end F-actin uncapping" EXACT []
synonym: "minus-end actin filament uncapping" EXACT []
synonym: "minus-end F-actin uncapping" EXACT []
synonym: "pointed end actin filament uncapping" EXACT []
synonym: "pointed end F-actin uncapping" EXACT []
synonym: "pointed-end F-actin uncapping" EXACT []
is_a: GO:0051695 ! actin filament uncapping

[Term]
id: GO:0051697
name: protein delipidation
namespace: biological_process
def: "The breakage of covalent bonds to detach lipid groups from a protein." [GOC:ai]
is_a: GO:0006464 ! cellular protein modification process

[Term]
id: GO:0051698
name: saccharopine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-saccharopine + O2 = L-2-aminoadipic 6-semialdehyde + L-glutamate + H2O2." [PMID:16233628]
synonym: "SAX activity" BROAD []
is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor

[Term]
id: GO:0051699
name: proline oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-proline + O2 + H2O = L-delta1-pyrroline-5-carboxylate + H2O2." [MetaCyc:RXN-821]
xref: EC:1.5.3.-
xref: MetaCyc:RXN-821
is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor

[Term]
id: GO:0051700
name: fructosyl-amino acid oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: fructosyl-amino acid + O2 = corresponding amino acid + glucosone + H2O2." [PMID:16233628]
synonym: "FAOD activity" EXACT []
xref: EC:1.5.3.-
is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor

[Term]
id: GO:0051701
name: interaction with host
namespace: biological_process
def: "An interaction between two organisms living together in more or less intimate association. The term host is used for the larger (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism." [GOC:cc]
subset: gosubset_prok
is_a: GO:0044419 ! interspecies interaction between organisms
relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism

[Term]
id: GO:0051702
name: interaction with symbiont
namespace: biological_process
def: "An interaction between two organisms living together in more or less intimate association. The term symbiont is used for the smaller (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism." [GOC:cc]
subset: gosubset_prok
is_a: GO:0044419 ! interspecies interaction between organisms
relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism

[Term]
id: GO:0051703
name: intraspecies interaction between organisms
namespace: biological_process
def: "Any process in which an organism has an effect on an organism of the same species." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "intraspecies interaction with other organisms" EXACT []
is_a: GO:0051704 ! multi-organism process

[Term]
id: GO:0051704
name: multi-organism process
namespace: biological_process
alt_id: GO:0051706
def: "A biological process which involves another organism of the same or different species." [GOC:jl]
subset: goslim_pir
subset: gosubset_prok
synonym: "interaction between organisms" EXACT []
synonym: "physiological interaction between organisms" EXACT []
synonym: "physiological interaction with other organism" EXACT []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0051705
name: multi-organism behavior
namespace: biological_process
alt_id: GO:0023032
alt_id: GO:0044709
def: "Any process in which an organism has a behavioral effect on another organism of the same or different species." [GOC:ai]
subset: goslim_pir
synonym: "behavioral interaction between organisms" EXACT []
synonym: "behavioral interaction with other organism" EXACT []
synonym: "behavioral signaling" NARROW []
synonym: "behavioral signalling" NARROW [GOC:mah]
synonym: "behavioural interaction between organisms" EXACT []
synonym: "behavioural interaction with other organism" EXACT []
is_a: GO:0007610 ! behavior
is_a: GO:0051704 ! multi-organism process

[Term]
id: GO:0051707
name: response to other organism
namespace: biological_process
alt_id: GO:0009613
alt_id: GO:0042828
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism." [GOC:ai]
subset: gosubset_prok
is_a: GO:0043207 ! response to external biotic stimulus
is_a: GO:0051704 ! multi-organism process

[Term]
id: GO:0051708
name: intracellular protein transport in other organism involved in symbiotic interaction
namespace: biological_process
def: "The directed movement of an organism's proteins within a cell of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "intracellular protein transport in other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0006886 ! intracellular protein transport
is_a: GO:1902583 ! multi-organism intracellular transport
relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism

[Term]
id: GO:0051709
name: regulation of killing of cells of other organism
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the killing by an organism of cells in another organism." [GOC:ai]
subset: gosubset_prok
synonym: "regulation of killing of cells of another organism" EXACT [GOC:bf]
is_a: GO:0031341 ! regulation of cell killing
is_a: GO:0043900 ! regulation of multi-organism process
is_a: GO:0065008 ! regulation of biological quality
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031640 ! killing of cells of other organism
relationship: regulates GO:0031640 ! killing of cells of other organism

[Term]
id: GO:0051710
name: regulation of cytolysis in other organism
namespace: biological_process
alt_id: GO:0001902
def: "Any process that modulates the frequency, rate or extent of the cytolysis by an organism of cells in another organism." [GOC:ai]
subset: gosubset_prok
synonym: "regulation of cytolysis of cells of another organism" EXACT [GOC:bf]
synonym: "regulation of cytolysis of cells of another, non-host, organism" NARROW []
is_a: GO:0042268 ! regulation of cytolysis
is_a: GO:0051709 ! regulation of killing of cells of other organism
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051715 ! cytolysis in other organism
relationship: regulates GO:0051715 ! cytolysis in other organism

[Term]
id: GO:0051711
name: negative regulation of killing of cells of other organism
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the killing by an organism of cells in another organism." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of killing of cells of another organism" EXACT []
synonym: "down-regulation of killing of cells of another organism" EXACT []
synonym: "downregulation of killing of cells of another organism" EXACT []
synonym: "inhibition of killing of cells of another organism" NARROW []
synonym: "negative regulation of killing of cells of another organism" EXACT [GOC:bf]
is_a: GO:0031342 ! negative regulation of cell killing
is_a: GO:0043901 ! negative regulation of multi-organism process
is_a: GO:0051709 ! regulation of killing of cells of other organism
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0031640 ! killing of cells of other organism
relationship: negatively_regulates GO:0031640 ! killing of cells of other organism

[Term]
id: GO:0051712
name: positive regulation of killing of cells of other organism
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the killing by an organism of cells in another organism." [GOC:ai]
subset: gosubset_prok
synonym: "activation of killing of cells of another organism" NARROW []
synonym: "stimulation of killing of cells of another organism" NARROW []
synonym: "up regulation of killing of cells of another organism" EXACT []
synonym: "up-regulation of killing of cells of another organism" EXACT []
synonym: "upregulation of killing of cells of another organism" EXACT []
is_a: GO:0031343 ! positive regulation of cell killing
is_a: GO:0043902 ! positive regulation of multi-organism process
is_a: GO:0051709 ! regulation of killing of cells of other organism
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0031640 ! killing of cells of other organism
relationship: positively_regulates GO:0031640 ! killing of cells of other organism

[Term]
id: GO:0051713
name: negative regulation of cytolysis in other organism
namespace: biological_process
alt_id: GO:0001903
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the cytolysis of cells in another organism." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of cytolysis of cells of another organism" EXACT []
synonym: "down-regulation of cytolysis of cells of another organism" EXACT []
synonym: "downregulation of cytolysis of cells of another organism" EXACT []
synonym: "inhibition of cytolysis of cells of another organism" NARROW []
synonym: "negative regulation of cytolysis of cells of another organism" EXACT [GOC:bf]
synonym: "negative regulation of cytolysis of cells of another, non-host, organism" NARROW []
is_a: GO:0045918 ! negative regulation of cytolysis
is_a: GO:0051710 ! regulation of cytolysis in other organism
is_a: GO:0051711 ! negative regulation of killing of cells of other organism
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051715 ! cytolysis in other organism
relationship: negatively_regulates GO:0051715 ! cytolysis in other organism

[Term]
id: GO:0051714
name: positive regulation of cytolysis in other organism
namespace: biological_process
alt_id: GO:0001904
def: "Any process that activates or increases the frequency, rate or extent of the cytolysis by an organism of cells in another organism." [GOC:ai]
subset: gosubset_prok
synonym: "activation of cytolysis of cells of another organism" NARROW []
synonym: "positive regulation of cytolysis of cells of another organism" EXACT [GOC:bf]
synonym: "positive regulation of cytolysis of cells of another, non-host, organism" NARROW []
synonym: "stimulation of cytolysis of cells of another organism" NARROW []
synonym: "up regulation of cytolysis of cells of another organism" EXACT []
synonym: "up-regulation of cytolysis of cells of another organism" EXACT []
synonym: "upregulation of cytolysis of cells of another organism" EXACT []
is_a: GO:0045919 ! positive regulation of cytolysis
is_a: GO:0051710 ! regulation of cytolysis in other organism
is_a: GO:0051712 ! positive regulation of killing of cells of other organism
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051715 ! cytolysis in other organism
relationship: positively_regulates GO:0051715 ! cytolysis in other organism

[Term]
id: GO:0051715
name: cytolysis in other organism
namespace: biological_process
alt_id: GO:0001901
def: "The killing by an organism of a cell in another organism by means of the rupture of cell membranes and the loss of cytoplasm." [GOC:ai]
subset: gosubset_prok
synonym: "cytolysis of cells of another organism" EXACT [GOC:bf]
synonym: "cytolysis of cells of another, non-host, organism" NARROW []
synonym: "cytolysis of cells of competing organism" NARROW []
is_a: GO:0019835 ! cytolysis
is_a: GO:0031640 ! killing of cells of other organism
is_a: GO:0044764 ! multi-organism cellular process

[Term]
id: GO:0051716
name: cellular response to stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell." [GOC:bf, GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
subset: gosubset_prok
is_a: GO:0009987 ! cellular process
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0051717
name: inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: inositol-1,3,4,5-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate." [GOC:bf, MetaCyc:3.1.3.62-RXN]
synonym: "inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase activity" EXACT [EC:2.7.1.-]
synonym: "inositol 1,3,4,5-tetrakisphosphate 3-phosphomonoesterase activity" EXACT [EC:2.7.1.-]
synonym: "inositol 1,3,4,5-tetrakisphosphate-5-phosphomonoesterase activity" EXACT [EC:2.7.1.-]
xref: MetaCyc:3.1.3.62-RXN
is_a: GO:0052743 ! inositol tetrakisphosphate phosphatase activity

[Term]
id: GO:0051718
name: DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + CpG (in DNA) = S-adenosyl-L-homocysteine + 5-MeCpG (in DNA)." [EC:2.1.1.37, PMID:15689527]
synonym: "HpaII methylase" NARROW [EC:2.1.1.37]
synonym: "HpaII' methylase" NARROW [EC:2.1.1.37]
synonym: "M.BsuRIa" NARROW [EC:2.1.1.37]
synonym: "M.BsuRIb" NARROW [EC:2.1.1.37]
is_a: GO:0003886 ! DNA (cytosine-5-)-methyltransferase activity

[Term]
id: GO:0051719
name: DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing CpN = S-adenosyl-L-homocysteine + DNA containing 5-MeCpN." [EC:2.1.1.37, PMID:15689527]
is_a: GO:0003886 ! DNA (cytosine-5-)-methyltransferase activity

[Term]
id: GO:0051720
name: DNA (cytosine-5-)-methyltransferase activity, acting on CpNpG substrates
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing CpNpG = S-adenosyl-L-homocysteine + DNA containing 5-MeCpNpG." [EC:2.1.1.37, PMID:15689527]
is_a: GO:0003886 ! DNA (cytosine-5-)-methyltransferase activity

[Term]
id: GO:0051721
name: protein phosphatase 2A binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the enzyme protein phosphatase 2A." [GOC:ai]
synonym: "protein phosphatase 2 binding" RELATED [GOC:rl]
is_a: GO:0019903 ! protein phosphatase binding

[Term]
id: GO:0051722
name: protein C-terminal methylesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: C-terminal protein amino acid methyl ester + H2O = protein amino acid + methanol." [PMID:10318862, PMID:8650216]
synonym: "protein phosphatase methylesterase activity" NARROW []
is_a: GO:0051723 ! protein methylesterase activity

[Term]
id: GO:0051723
name: protein methylesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein amino acid methyl ester + H2O = protein amino acid + methanol." [GOC:ai]
subset: gosubset_prok
synonym: "PME activity" EXACT [EC:2.7.1.-]
synonym: "protein carboxyl methylesterase activity" EXACT [EC:2.7.1.-]
synonym: "protein carboxylic ester hydrolase activity" EXACT []
synonym: "protein methyl-esterase activity" EXACT [EC:2.7.1.-]
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0051724
name: NAD transporter activity
namespace: molecular_function
def: "Enables the directed movement of nicotinamide adenine dinucleotide into, out of or within a cell, or between cells; transport may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:ai]
synonym: "NAD (oxidized) transporter activity" EXACT []
synonym: "NAD (reduced) transporter activity" EXACT []
synonym: "NAD+ transporter activity" EXACT []
synonym: "NADH transporter activity" EXACT []
synonym: "oxidized NAD transporter activity" EXACT []
synonym: "reduced NAD transporter activity" EXACT []
is_a: GO:0051184 ! cofactor transporter activity
relationship: part_of GO:0043132 ! NAD transport

[Term]
id: GO:0051725
name: protein de-ADP-ribosylation
namespace: biological_process
def: "The process of removing one or more ADP-ribose residues from a protein." [GOC:ai]
synonym: "poly(ADP-ribose) removal from protein" EXACT []
synonym: "protein amino acid de-ADP-ribosylation" EXACT [GOC:bf]
synonym: "protein poly(ADP-ribose) catabolic process" EXACT []
synonym: "protein poly(ADP-ribose) catabolism" EXACT []
synonym: "protein poly(ADP-ribose) degradation" EXACT []
synonym: "protein poly(ADP-ribose) hydrolysis" EXACT []
synonym: "removal of ADP-ribose from protein" EXACT []
is_a: GO:0006464 ! cellular protein modification process

[Term]
id: GO:0051726
name: regulation of cell cycle
namespace: biological_process
alt_id: GO:0000074
def: "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]
subset: goslim_yeast
subset: gosubset_prok
synonym: "cell cycle modulation" EXACT []
synonym: "cell cycle regulation" EXACT []
synonym: "cell cycle regulator" RELATED []
synonym: "control of cell cycle progression" EXACT []
synonym: "modulation of cell cycle progression" EXACT []
synonym: "regulation of cell cycle progression" EXACT []
synonym: "regulation of progression through cell cycle" EXACT []
synonym: "tumor suppressor" RELATED []
xref: Reactome:REACT_100159 "Inactivation of Myt1 kinase, Mus musculus"
xref: Reactome:REACT_1006 "Polo-like kinase mediated events, Homo sapiens"
xref: Reactome:REACT_102418 "Polo-like kinase mediated events, Schizosaccharomyces pombe"
xref: Reactome:REACT_102475 "Inactivation of Myt1 kinase, Rattus norvegicus"
xref: Reactome:REACT_103468 "Activation of Cdc25C, Drosophila melanogaster"
xref: Reactome:REACT_104523 "Inactivation of Wee1 kinase, Bos taurus"
xref: Reactome:REACT_105454 "Polo-like kinase mediated events, Dictyostelium discoideum"
xref: Reactome:REACT_106237 "Polo-like kinase mediated events, Caenorhabditis elegans"
xref: Reactome:REACT_106324 "Activation of Cdc25C, Mus musculus"
xref: Reactome:REACT_107424 "Inactivation of Myt1 kinase, Canis familiaris"
xref: Reactome:REACT_108578 "Inactivation of Myt1 kinase, Xenopus tropicalis"
xref: Reactome:REACT_109244 "Inactivation of Myt1 kinase, Schizosaccharomyces pombe"
xref: Reactome:REACT_109507 "Polo-like kinase mediated events, Taeniopygia guttata"
xref: Reactome:REACT_109584 "Polo-like kinase mediated events, Saccharomyces cerevisiae"
xref: Reactome:REACT_110774 "Inactivation of Myt1 kinase, Drosophila melanogaster"
xref: Reactome:REACT_112480 "Inactivation of Wee1 kinase, Dictyostelium discoideum"
xref: Reactome:REACT_113569 "Activation of Cdc25C, Saccharomyces cerevisiae"
xref: Reactome:REACT_113990 "Activation of Cdc25C, Schizosaccharomyces pombe"
xref: Reactome:REACT_114323 "Activation of Cdc25C, Caenorhabditis elegans"
xref: Reactome:REACT_1944 "Inactivation of Wee1 kinase, Homo sapiens"
xref: Reactome:REACT_2119 "Activation of Cdc25C, Homo sapiens"
xref: Reactome:REACT_28091 "Inactivation of Wee1 kinase, Canis familiaris"
xref: Reactome:REACT_29213 "Activation of Cdc25C, Rattus norvegicus"
xref: Reactome:REACT_30490 "Inactivation of Myt1 kinase, Danio rerio"
xref: Reactome:REACT_30836 "Inactivation of Myt1 kinase, Bos taurus"
xref: Reactome:REACT_30859 "Polo-like kinase mediated events, Gallus gallus"
xref: Reactome:REACT_32077 "Inactivation of Myt1 kinase, Dictyostelium discoideum"
xref: Reactome:REACT_34285 "Activation of Cdc25C, Bos taurus"
xref: Reactome:REACT_414 "Inactivation of Myt1 kinase, Homo sapiens"
xref: Reactome:REACT_80617 "Inactivation of Wee1 kinase, Xenopus tropicalis"
xref: Reactome:REACT_81789 "Polo-like kinase mediated events, Drosophila melanogaster"
xref: Reactome:REACT_82824 "Inactivation of Wee1 kinase, Rattus norvegicus"
xref: Reactome:REACT_83089 "Inactivation of Myt1 kinase, Saccharomyces cerevisiae"
xref: Reactome:REACT_83883 "Polo-like kinase mediated events, Canis familiaris"
xref: Reactome:REACT_87352 "Polo-like kinase mediated events, Danio rerio"
xref: Reactome:REACT_88486 "Inactivation of Wee1 kinase, Taeniopygia guttata"
xref: Reactome:REACT_89122 "Activation of Cdc25C, Canis familiaris"
xref: Reactome:REACT_91085 "Inactivation of Wee1 kinase, Danio rerio"
xref: Reactome:REACT_92033 "Inactivation of Myt1 kinase, Caenorhabditis elegans"
xref: Reactome:REACT_93521 "Polo-like kinase mediated events, Mus musculus"
xref: Reactome:REACT_93702 "Polo-like kinase mediated events, Rattus norvegicus"
xref: Reactome:REACT_95088 "Inactivation of Wee1 kinase, Mus musculus"
xref: Reactome:REACT_96524 "Activation of Cdc25C, Xenopus tropicalis"
xref: Reactome:REACT_97306 "Polo-like kinase mediated events, Bos taurus"
xref: Reactome:REACT_97384 "Polo-like kinase mediated events, Xenopus tropicalis"
xref: Reactome:REACT_98443 "Inactivation of Wee1 kinase, Gallus gallus"
xref: Reactome:REACT_99158 "Inactivation of Wee1 kinase, Drosophila melanogaster"
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007049 ! cell cycle
relationship: regulates GO:0007049 ! cell cycle

[Term]
id: GO:0051727
name: obsolete cell cycle switching, meiotic to mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. The process in which a cell switches cell cycle mode from meiotic to mitotic division." [GOC:ai, GOC:mtg_cell_cycle]
comment: This term was made obsolete because it does not refer to a real biological process.
synonym: "cell cycle switching, meiosis to mitosis" NARROW []
synonym: "cell cycle switching, meiotic to mitotic cell cycle" EXACT []
synonym: "conversion to mitosis" NARROW []
synonym: "conversion to mitotic cell cycle" EXACT []
synonym: "entry into mitosis" NARROW []
synonym: "entry into mitotic cell cycle" EXACT []
synonym: "initiation of mitosis" NARROW []
synonym: "initiation of mitotic cell cycle" EXACT []
synonym: "mitotic entry" NARROW []
is_obsolete: true

[Term]
id: GO:0051728
name: cell cycle switching, mitotic to meiotic cell cycle
namespace: biological_process
alt_id: GO:0042061
def: "The process in which a cell switches cell cycle mode from mitotic to meiotic division." [GOC:ai, GOC:mtg_cell_cycle]
synonym: "cell cycle switching, mitosis to meiosis" NARROW []
synonym: "conversion to meiosis" NARROW []
synonym: "conversion to meiotic cell cycle" EXACT []
synonym: "entry into meiosis" NARROW []
synonym: "entry into meiotic cell cycle" EXACT []
synonym: "initiation of meiosis" NARROW []
synonym: "initiation of meiotic cell cycle" EXACT []
synonym: "meiotic entry" NARROW []
is_a: GO:0045930 ! negative regulation of mitotic cell cycle
is_a: GO:0051446 ! positive regulation of meiotic cell cycle
is_a: GO:0060184 ! cell cycle switching

[Term]
id: GO:0051729
name: germline cell cycle switching, mitotic to meiotic cell cycle
namespace: biological_process
def: "The process in which a germline cell switches cell cycle mode from mitotic to meiotic division." [GOC:ai]
synonym: "germline cell cycle switching, mitosis to meiosis" NARROW []
synonym: "germline conversion to meiosis" NARROW []
synonym: "germline conversion to meiotic cell cycle" EXACT []
synonym: "germline entry into meiosis" NARROW []
synonym: "germline entry into meiotic cell cycle" EXACT []
synonym: "germline initiation of meiosis" NARROW []
synonym: "germline initiation of meiotic cell cycle" EXACT []
synonym: "germline meiotic entry" NARROW []
is_a: GO:0051728 ! cell cycle switching, mitotic to meiotic cell cycle

[Term]
id: GO:0051730
name: GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP + 5'-dephospho-RNA = GDP + 5'-phospho-RNA." [EC:2.7.1.78, PMID:8428918]
synonym: "GTP-dependent polynucleotide 5'-hydroxyl-kinase activity" BROAD []
synonym: "GTP-dependent polyribonucleotide kinase activity" EXACT []
synonym: "GTP-dependent RNA 5'-hydroxyl-kinase activity" EXACT []
synonym: "GTP-dependent RNA kinase activity" EXACT []
synonym: "GTP:5'-dephosphopolyribonucleotide 5'-phosphotransferase activity" EXACT []
is_a: GO:0051732 ! polyribonucleotide kinase activity
is_a: GO:0051735 ! GTP-dependent polynucleotide kinase activity

[Term]
id: GO:0051731
name: polynucleotide 5'-hydroxyl-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: NTP + 5'-dephosphopolynucleotide = NDP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA." [EC:2.7.1.78]
synonym: "5'-dephosphopolynucleotide kinase activity" EXACT []
synonym: "5'-hydroxyl polynucleotide kinase activity" EXACT [EC:2.7.1.78]
synonym: "PNK" RELATED [EC:2.7.1.78]
synonym: "polynucleotide 5'-hydroxy-kinase activity" EXACT [EC:2.7.1.78]
synonym: "polynucleotide 5'-hydroxyl kinase (phosphorylating) activity" EXACT [EC:2.7.1.78]
synonym: "polynucleotide kinase activity" BROAD [EC:2.7.1.78]
xref: EC:2.7.1.-
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019205 ! nucleobase-containing compound kinase activity

[Term]
id: GO:0051732
name: polyribonucleotide kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: NTP + 5'-dephospho-RNA = NDP + 5'-phospho-RNA." [EC:2.7.1.78]
synonym: "5'-hydroxyl polyribonucleotide kinase activity" EXACT [EC:2.7.1.78]
synonym: "5'-hydroxyl RNA kinase activity" EXACT [EC:2.7.1.78]
synonym: "RNA 5'-hydroxyl kinase activity" EXACT []
synonym: "RNA kinase activity" EXACT []
is_a: GO:0051731 ! polynucleotide 5'-hydroxyl-kinase activity

[Term]
id: GO:0051733
name: polydeoxyribonucleotide kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: NTP + 5'-dephospho-DNA = NDP + 5'-phospho-DNA." [EC:2.7.1.78]
synonym: "DNA 5'-hydroxyl kinase activity" EXACT []
synonym: "DNA kinase activity" EXACT []
is_a: GO:0051731 ! polynucleotide 5'-hydroxyl-kinase activity

[Term]
id: GO:0051734
name: ATP-dependent polynucleotide kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 5'-dephosphopolynucleotide = ADP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA." [EC:2.7.1.78]
synonym: "ATP-dependent polynucleotide 5'-hydroxyl-kinase activity" EXACT []
synonym: "ATP:5'-dephosphopolynucleotide 5'-phosphatase activity" EXACT [EC:2.7.1.78]
synonym: "ATP:5'-dephosphopolynucleotide 5'-phosphotransferase activity" EXACT []
xref: EC:2.7.1.-
is_a: GO:0051731 ! polynucleotide 5'-hydroxyl-kinase activity

[Term]
id: GO:0051735
name: GTP-dependent polynucleotide kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP + 5'-dephosphopolynucleotide = GDP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA." [EC:2.7.1.78]
synonym: "GTP-dependent polynucleotide 5'-hydroxyl-kinase activity" EXACT []
synonym: "GTP:5'-dephosphopolynucleotide 5'-phosphotransferase activity" EXACT []
xref: EC:2.7.1.-
is_a: GO:0051731 ! polynucleotide 5'-hydroxyl-kinase activity

[Term]
id: GO:0051736
name: ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 5'-dephospho-RNA = ADP + 5'-phospho-RNA." [EC:2.7.1.78]
synonym: "ATP-dependent polynucleotide 5'-hydroxyl-kinase activity" BROAD []
synonym: "ATP-dependent polyribonucleotide kinase activity" EXACT []
synonym: "ATP-dependent RNA 5'-hydroxyl-kinase activity" EXACT []
synonym: "ATP-dependent RNA kinase activity" EXACT []
synonym: "ATP:5'-dephosphopolyribonucleotide 5'-phosphotransferase activity" EXACT []
is_a: GO:0051732 ! polyribonucleotide kinase activity
is_a: GO:0051734 ! ATP-dependent polynucleotide kinase activity

[Term]
id: GO:0051737
name: GTP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP + 5'-dephospho-DNA = GDP + 5'-phospho-DNA." [EC:2.7.1.78, PMID:8428918]
synonym: "GTP-dependent DNA 5'-hydroxyl-kinase activity" EXACT []
synonym: "GTP-dependent DNA kinase activity" EXACT []
synonym: "GTP-dependent polydeoxyribonucleotide kinase activity" EXACT []
synonym: "GTP-dependent polynucleotide 5'-hydroxyl-kinase activity" BROAD []
synonym: "GTP:5'-dephosphopolydeoxyribonucleotide 5'-phosphotransferase activity" EXACT []
is_a: GO:0051733 ! polydeoxyribonucleotide kinase activity
is_a: GO:0051735 ! GTP-dependent polynucleotide kinase activity

[Term]
id: GO:0051738
name: xanthophyll binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with xanthophylls, any of several neutral yellow to orange carotenoid pigments containing oxygen." [ISBN:0122146743]
is_a: GO:0019840 ! isoprenoid binding
is_a: GO:0031409 ! pigment binding

[Term]
id: GO:0051740
name: ethylene binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator." [GOC:ai]
synonym: "ethene binding" EXACT []
is_a: GO:0072328 ! alkene binding

[Term]
id: GO:0051741
name: 2-methyl-6-phytyl-1,4-benzoquinone methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-methyl-6-phytyl-1,4-benzoquinone + S-adenosyl-methionine = 2,3-dimethyl-6-phytyl-1,4-benzoquinone + S-adenosyl-homocysteine." [MetaCyc:RXN-2542]
synonym: "MPBQ methyltransferase activity" EXACT []
xref: MetaCyc:RXN-2542
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0051742
name: 2-methyl-6-solanyl-1,4-benzoquinone methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-methyl-6-solanyl-1,4-benzoquinone + S-adenosyl-methionine = 2,3-dimethyl-6-solanyl-1,4-benzoquinone + S-adenosyl-homocysteine." [MetaCyc:RXN-2762]
synonym: "MSBQ methyltransferase activity" EXACT []
xref: MetaCyc:RXN-2762
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0051743
name: red chlorophyll catabolite reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: red chlorophyll catabolite + reduced ferredoxin + 2 H+ = primary fluorescent catabolite + oxidized ferredoxin. This reaction is the reduction of the C20/C1 double bond in the pyrrole system of red chlorophyll catabolite (RCC) to a colorless tetrapyrrole (pFCC) with a strong blue fluorescence." [PMID:10743659]
synonym: "RCC reductase activity" EXACT []
xref: EC:1.3.7.-
xref: MetaCyc:RXN-7741
is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0051744
name: 3,8-divinyl protochlorophyllide a 8-vinyl reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: divinyl protochlorophyllide a + NADPH + H+ = monovinyl protochlorophyllide a + NADP+." [MetaCyc:RXN1F-72]
xref: MetaCyc:RXN1F-72
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0051745
name: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H + H+ = isopentenyl diphosphate + NAD(P)+ + H2O. Note that (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate is an alternative name for 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate." [EC:1.17.1.2]
synonym: "4-hydroxy-3-methylbut-2-enyl diphosphate reductase activity" EXACT [EC:1.17.1.2]
synonym: "isopentenyl-diphosphate:NAD(P)+ oxidoreductase activity" EXACT []
xref: EC:1.17.1.2
xref: MetaCyc:ISPH2-RXN
is_a: GO:0016726 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor

[Term]
id: GO:0051746
name: thalianol synthase activity
namespace: molecular_function
def: "Catalysis of the cyclization of 3(S)-oxidosqualene to (3S,13S,14R)-malabarica-8,17,21-trien-3-ol (thalianol)." [PMID:15125655]
subset: mf_needs_review
is_a: GO:0031559 ! oxidosqualene cyclase activity

[Term]
id: GO:0051747
name: cytosine C-5 DNA demethylase activity
namespace: molecular_function
def: "Catalysis of the reaction: methyl-dCpdG DNA + H2O = dCpdG DNA + methanol. This reaction is the hydrolytic removal of the methyl group on the 5 position of cytosine in DNA." [PMID:10050851]
synonym: "DNA demethylase activity" BROAD [PMID:10050851]
synonym: "DNA methyltransferase activity acting on cytosine C-5" EXACT []
synonym: "hydrolytic DNA demethylase activity" BROAD []
is_a: GO:0016787 ! hydrolase activity
is_a: GO:0035514 ! DNA demethylase activity

[Term]
id: GO:0051748
name: UTP-monosaccharide-1-phosphate uridylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UTP + a monosaccharide 1-phosphate = diphosphate + UDP-monosaccharide." [EC:2.7.7.64, PMID:15326166]
subset: gosubset_prok
synonym: "PsUSP" RELATED [EC:2.7.7.64]
synonym: "UDP-monosaccharide diphosphorylase activity" EXACT []
synonym: "UDP-monosaccharide pyrophosphorylase activity" EXACT []
synonym: "UDP-sugar pyrophosphorylase activity" EXACT [EC:2.7.7.64]
synonym: "USP" RELATED [EC:2.7.7.64]
xref: EC:2.7.7.64
xref: MetaCyc:2.7.7.64-RXN
is_a: GO:0070569 ! uridylyltransferase activity

[Term]
id: GO:0051749
name: indole acetic acid carboxyl methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: indole acetic acid + S-adenosyl-methionine = methyl indole acetic acid ester + S-adenosyl-homocysteine." [PMID:16169896]
synonym: "IAA carboxyl methyltransferase activity" EXACT []
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0051750
name: delta3,5-delta2,4-dienoyl-CoA isomerase activity
namespace: molecular_function
def: "Catalysis of the isomerization of 3,5-dienoyl-CoA to 2,4-dienoyl-CoA." [PMID:16040662]
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0051751
name: alpha-1,4-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->4) linkage." [PMID:15772281]
is_a: GO:0000030 ! mannosyltransferase activity

[Term]
id: GO:0051752
name: phosphoglucan, water dikinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + [phospho-alpha-glucan] + H2O = AMP + O-phospho-[phospho-alpha-glucan] + phosphate." [EC:2.7.9.5, PMID:15618411]
synonym: "ATP:phospho-alpha-glucan, water phosphotransferase activity" EXACT [EC:2.7.9.5]
synonym: "OK1" RELATED [EC:2.7.9.5]
synonym: "PWD" RELATED [EC:2.7.9.5]
xref: EC:2.7.9.5
xref: MetaCyc:2.7.9.5-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016781 ! phosphotransferase activity, paired acceptors

[Term]
id: GO:0051753
name: mannan synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: mannan(n) + GDP-mannose = mannan(n+1) + GDP. This reaction is the formation of the beta-(1->4)-linked mannan backbone in substrates such as galactomannan." [PMID:14726589]
synonym: "galactomannan beta-1,4-mannosyltransferase activity" NARROW []
synonym: "mannan beta-1,4-mannosyltransferase activity" EXACT []
is_a: GO:0019187 ! beta-1,4-mannosyltransferase activity

[Term]
id: GO:0051754
name: meiotic sister chromatid cohesion, centromeric
namespace: biological_process
def: "The cell cycle process in which centromeres of sister chromatids are joined during meiosis." [PMID:14730319, PMID:16325576]
synonym: "centromeric meiotic sister chromatin cohesion" EXACT [GOC:bf]
synonym: "meiotic sister chromatid cohesion at centromere" EXACT []
synonym: "sister chromatid cohesion at centromere at meiosis I" EXACT []
is_a: GO:0051177 ! meiotic sister chromatid cohesion
is_a: GO:0070601 ! centromeric sister chromatid cohesion

[Term]
id: GO:0051755
name: meiotic sister chromatid arm separation
namespace: biological_process
def: "The cell cycle process in which sister chromatid arms are physically detached from each other during meiosis." [GOC:ai]
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0007127 ! meiosis I
relationship: part_of GO:0051757 ! meiotic sister chromatid separation

[Term]
id: GO:0051756
name: meiotic sister chromatid centromere separation
namespace: biological_process
def: "The cell cycle process in which the centromeres of sister chromatids are physically detached from each other during meiosis." [GOC:ai, PMID:14730319, PMID:16325576]
is_a: GO:0034510 ! centromere separation
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0045144 ! meiotic sister chromatid segregation
relationship: part_of GO:0051757 ! meiotic sister chromatid separation

[Term]
id: GO:0051757
name: meiotic sister chromatid separation
namespace: biological_process
def: "The process in which sister chromatids are physically detached from each other during meiosis." [GOC:ai, PMID:14730319, PMID:16325576]
synonym: "meiotic sister chromatid resolution" EXACT [GOC:mah]
is_a: GO:0051307 ! meiotic chromosome separation

[Term]
id: GO:0051758
name: homologous chromosome movement towards spindle pole involved in homologous chromosome segregation
namespace: biological_process
def: "The directed movement of homologous chromosomes from the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, that contributes to meiosis I." [GOC:ai]
synonym: "homologous chromosome movement towards spindle pole during meiosis I" RELATED [GOC:dph, GOC:tb]
synonym: "meiosis I, homologous chromosome movement towards spindle pole" EXACT []
is_a: GO:0016344 ! meiotic chromosome movement towards spindle pole
relationship: part_of GO:0045143 ! homologous chromosome segregation

[Term]
id: GO:0051759
name: sister chromosome movement towards spindle pole involved in meiotic sister chromatid segregation
namespace: biological_process
def: "The directed movement of sister chromosomes from the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during meiosis II." [GOC:ai]
synonym: "meiosis II, sister chromosome movement towards spindle pole" EXACT []
synonym: "sister chromosome movement towards spindle pole during meiosis II" RELATED [GOC:dph, GOC:tb]
is_a: GO:0016344 ! meiotic chromosome movement towards spindle pole
relationship: part_of GO:0045144 ! meiotic sister chromatid segregation

[Term]
id: GO:0051760
name: meiotic sister chromatid cohesion, arms
namespace: biological_process
def: "The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the length of the chromosome arms during meiosis." [PMID:14730319, PMID:16325576]
synonym: "meiotic sister chromatid cohesion along arms" EXACT []
synonym: "sister chromatid cohesion along arms at meiosis I" EXACT []
is_a: GO:0051177 ! meiotic sister chromatid cohesion

[Term]
id: GO:0051761
name: sesquiterpene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sesquiterpenes, any of a class of terpenes of the formula C15H24 or a derivative of such a terpene." [GOC:ai]
subset: gosubset_prok
synonym: "sesquiterpene metabolism" EXACT []
is_a: GO:0042214 ! terpene metabolic process

[Term]
id: GO:0051762
name: sesquiterpene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sesquiterpenes, any of a class of terpenes of the formula C15H24 or a derivative of such a terpene." [GOC:ai]
subset: gosubset_prok
is_a: GO:0046246 ! terpene biosynthetic process
is_a: GO:0051761 ! sesquiterpene metabolic process

[Term]
id: GO:0051763
name: sesquiterpene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of sesquiterpenes, any of a class of terpenes of the formula C15H24 or a derivative of such a terpene." [GOC:ai]
subset: gosubset_prok
is_a: GO:0046247 ! terpene catabolic process
is_a: GO:0051761 ! sesquiterpene metabolic process

[Term]
id: GO:0051764
name: actin crosslink formation
namespace: biological_process
def: "The process in which two or more actin filaments are connected together by proteins that act as crosslinks between the filaments. The crosslinked filaments may be on the same or differing axes." [GOC:ai]
comment: See also the molecular function term 'protein binding, bridging ; GO:0030674'.
synonym: "actin bundling" RELATED []
synonym: "actin crosslinking" EXACT []
synonym: "bridging actin filaments" NARROW []
synonym: "formation of actin crosslink" EXACT []
is_a: GO:0007015 ! actin filament organization

[Term]
id: GO:0051765
name: inositol tetrakisphosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: inositol tetrakisphosphate + ATP = inositol pentakisphosphate + ADP." [GOC:ai]
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0051766
name: inositol trisphosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: inositol trisphosphate + ATP = inositol tetrakisphosphate + ADP." [GOC:ai]
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0051767
name: nitric-oxide synthase biosynthetic process
namespace: biological_process
alt_id: GO:0051768
def: "The chemical reactions and pathways resulting in the formation of a nitric-oxide synthase, an enzyme which catalyzes the reaction L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+." [EC:1.14.13.39, GOC:ai]
synonym: "brain nitric-oxide synthase biosynthetic process" NARROW [GOC:bf]
synonym: "endothelial nitric-oxide synthase biosynthetic process" NARROW [GOC:bf]
synonym: "inducible nitric-oxide synthase biosynthetic process" NARROW [GOC:bf]
synonym: "nitric-oxide synthase (type 2) biosynthesis" NARROW []
synonym: "nitric-oxide synthase (type 2) biosynthetic process" NARROW []
synonym: "nitric-oxide synthase (type II) biosynthesis" NARROW []
synonym: "nitric-oxide synthase (type II) biosynthetic process" NARROW []
synonym: "nitric-oxide synthase 2 biosynthetic process" NARROW []
synonym: "nitric-oxide synthase-1 biosynthetic process" NARROW [GOC:bf]
synonym: "nitric-oxide synthase-2 biosynthetic process" NARROW [GOC:bf]
synonym: "nitric-oxide synthase-3 biosynthetic process" NARROW [GOC:bf]
synonym: "NO synthase biosynthesis" EXACT []
synonym: "NO synthase biosynthetic process" EXACT []
synonym: "NOS biosynthesis" EXACT []
synonym: "NOS biosynthetic process" EXACT []
synonym: "NOS1 biosynthesis" NARROW [GOC:bf]
synonym: "NOS2 biosynthesis" NARROW [GOC:bf]
synonym: "NOS2 synthase biosynthesis" NARROW []
synonym: "NOS2 synthase biosynthetic process" NARROW []
synonym: "NOS3 biosynthesis" NARROW [GOC:bf]
is_a: GO:0009059 ! macromolecule biosynthetic process

[Term]
id: GO:0051769
name: regulation of nitric-oxide synthase biosynthetic process
namespace: biological_process
alt_id: GO:0051772
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric-oxide synthase enzyme." [GOC:ai]
synonym: "regulation of nitric-oxide synthase (type 2) biosynthesis" NARROW []
synonym: "regulation of nitric-oxide synthase (type 2) biosynthetic process" NARROW []
synonym: "regulation of nitric-oxide synthase (type II) biosynthesis" NARROW []
synonym: "regulation of nitric-oxide synthase (type II) biosynthetic process" NARROW []
synonym: "regulation of nitric-oxide synthase 2 biosynthetic process" NARROW []
synonym: "regulation of NO synthase biosynthesis" EXACT []
synonym: "regulation of NO synthase biosynthetic process" EXACT []
synonym: "regulation of NOS biosynthesis" EXACT []
synonym: "regulation of NOS biosynthetic process" EXACT []
synonym: "regulation of NOS2 synthase biosynthesis" NARROW []
synonym: "regulation of NOS2 synthase biosynthetic process" NARROW []
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051767 ! nitric-oxide synthase biosynthetic process
relationship: regulates GO:0051767 ! nitric-oxide synthase biosynthetic process

[Term]
id: GO:0051770
name: positive regulation of nitric-oxide synthase biosynthetic process
namespace: biological_process
alt_id: GO:0051773
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric oxide synthase enzyme." [GOC:ai]
synonym: "activation of nitric-oxide synthase 2 biosynthetic process" NARROW []
synonym: "activation of nitric-oxide synthase biosynthetic process" NARROW []
synonym: "positive regulation of nitric-oxide synthase (type 2) biosynthesis" NARROW []
synonym: "positive regulation of nitric-oxide synthase (type 2) biosynthetic process" NARROW []
synonym: "positive regulation of nitric-oxide synthase (type II) biosynthesis" NARROW []
synonym: "positive regulation of nitric-oxide synthase (type II) biosynthetic process" NARROW []
synonym: "positive regulation of nitric-oxide synthase 2 biosynthetic process" NARROW []
synonym: "positive regulation of NO synthase biosynthesis" EXACT []
synonym: "positive regulation of NO synthase biosynthetic process" EXACT []
synonym: "positive regulation of NOS biosynthesis" EXACT []
synonym: "positive regulation of NOS biosynthetic process" EXACT []
synonym: "positive regulation of NOS2 synthase biosynthesis" NARROW []
synonym: "positive regulation of NOS2 synthase biosynthetic process" NARROW []
synonym: "stimulation of nitric-oxide synthase 2 biosynthetic process" NARROW []
synonym: "stimulation of nitric-oxide synthase biosynthetic process" NARROW []
synonym: "up regulation of nitric-oxide synthase 2 biosynthetic process" NARROW []
synonym: "up regulation of nitric-oxide synthase biosynthetic process" EXACT []
synonym: "up-regulation of nitric-oxide synthase 2 biosynthetic process" NARROW []
synonym: "up-regulation of nitric-oxide synthase biosynthetic process" EXACT []
synonym: "upregulation of nitric-oxide synthase 2 biosynthetic process" NARROW []
synonym: "upregulation of nitric-oxide synthase biosynthetic process" EXACT []
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0051769 ! regulation of nitric-oxide synthase biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051767 ! nitric-oxide synthase biosynthetic process
relationship: positively_regulates GO:0051767 ! nitric-oxide synthase biosynthetic process

[Term]
id: GO:0051771
name: negative regulation of nitric-oxide synthase biosynthetic process
namespace: biological_process
alt_id: GO:0051774
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric-oxide synthase enzyme." [GOC:ai]
synonym: "down regulation of nitric-oxide synthase 2 biosynthetic process" NARROW []
synonym: "down regulation of nitric-oxide synthase biosynthetic process" EXACT []
synonym: "down-regulation of nitric-oxide synthase 2 biosynthetic process" NARROW []
synonym: "down-regulation of nitric-oxide synthase biosynthetic process" EXACT []
synonym: "downregulation of nitric-oxide synthase 2 biosynthetic process" NARROW []
synonym: "downregulation of nitric-oxide synthase biosynthetic process" EXACT []
synonym: "inhibition of nitric-oxide synthase 2 biosynthetic process" NARROW []
synonym: "inhibition of nitric-oxide synthase biosynthetic process" NARROW []
synonym: "negative regulation of nitric-oxide synthase (type 2) biosynthesis" NARROW []
synonym: "negative regulation of nitric-oxide synthase (type 2) biosynthetic process" NARROW []
synonym: "negative regulation of nitric-oxide synthase (type II) biosynthesis" NARROW []
synonym: "negative regulation of nitric-oxide synthase (type II) biosynthetic process" NARROW []
synonym: "negative regulation of nitric-oxide synthase 2 biosynthetic process" NARROW []
synonym: "negative regulation of NO synthase biosynthesis" EXACT []
synonym: "negative regulation of NO synthase biosynthetic process" EXACT []
synonym: "negative regulation of NOS biosynthesis" EXACT []
synonym: "negative regulation of NOS biosynthetic process" EXACT []
synonym: "negative regulation of NOS2 synthase biosynthesis" NARROW []
synonym: "negative regulation of NOS2 synthase biosynthetic process" NARROW []
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
is_a: GO:0051769 ! regulation of nitric-oxide synthase biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051767 ! nitric-oxide synthase biosynthetic process
relationship: negatively_regulates GO:0051767 ! nitric-oxide synthase biosynthetic process

[Term]
id: GO:0051775
name: response to redox state
namespace: biological_process
alt_id: GO:0006980
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating redox state. Redox state refers to the balance of oxidized versus reduced forms of electron donors and acceptors in an organelle, cell or organ; plastoquinone, glutathione (GSH/GSSG), and nicotinamide nucleotides (NAD+/NADH and NADP+/NADPH) are among the most important." [GOC:mah, PMID:15131240, PMID:16987039]
subset: gosubset_prok
synonym: "redox signal response" EXACT []
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0051776
name: detection of redox state
namespace: biological_process
def: "The series of events in which a chemical stimulus indicating redox state is received and converted into a molecular signal. Redox state refers to the balance of oxidized versus reduced forms of electron donors and acceptors in an organelle, cell or organ; plastoquinone, glutathione (GSH/GSSG), and nicotinamide nucleotides (NAD+/NADH and NADP+/NADPH) are among the most important." [GOC:mah, PMID:15131240, PMID:16987039]
synonym: "redox sensing" EXACT []
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0051775 ! response to redox state

[Term]
id: GO:0051777
name: ent-kaurenoate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: ent-kaurenoate + NADPH + O2 = ent-7-alpha-hydroxykaurenoate + NADP+ + H2O. This is the first of three successive reactions resulting in the oxidation of ent-kaurenoate (ent-kaurenoic acid) to gibberellin 12 (GA12)." [EC:1.14.13.79, MetaCyc:RXN1F-159]
comment: Note that the enzyme ent-kaurenoate oxidase also catalyzes the reactions represented by the molecular function terms 'ent-7-alpha-hydroxykaurenoate oxidase activity ; GO:0051778' and 'gibberellin 12-aldehyde oxidase activity ; GO:0051779'.
synonym: "ent-kaur-16-en-19-oate,NADPH:oxygen oxidoreductase (hydroxylating) activity" EXACT [EC:1.14.13.79]
synonym: "ent-kaurenoic acid oxidase activity" EXACT []
xref: MetaCyc:1.14.13.79-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0051778
name: ent-7-alpha-hydroxykaurenoate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: ent-7-alpha-hydroxykaurenoate + NADPH + H+ + O2 = gibberellin 12-aldehyde + NADP+ + 2 H2O. This is the second of three successive reactions resulting in the oxidation of ent-kaurenoate (ent-kaurenoic acid) to gibberellin 12 (GA12)." [EC:1.14.13.79, MetaCyc:RXN1F-160]
comment: Note that the enzyme ent-kaurenoate oxidase also catalyzes the reactions represented by the molecular function terms 'ent-kaurenoate oxidase activity ; GO:0051777' and 'gibberellin 12-aldehyde oxidase activity ; GO:0051779'.
xref: MetaCyc:RXN1F-160
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0051779
name: gibberellin 12-aldehyde oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: gibberellin 12-aldehyde + NADPH + H+ + O2 = gibberellin 12 + NADP+ + H2O. This is the third of three successive reactions resulting in the oxidation of ent-kaurenoate (ent-kaurenoic acid) to gibberellin 12 (GA12)." [EC:1.14.13.79, MetaCyc:RXN1F-161]
comment: Note that the enzyme ent-kaurenoate oxidase also catalyzes the reactions represented by the molecular function terms 'ent-kaurenoate oxidase activity ; GO:0051777' and 'ent-7-alpha-hydroxykaurenoate oxidase activity ; GO:0051778'.
synonym: "GA12-aldehyde oxidase activity" EXACT []
xref: MetaCyc:RXN1F-161
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0051780
name: behavioral response to nutrient
namespace: biological_process
def: "Any process that results in a change in the behavior of an organism as a result of a nutrient stimulus." [GOC:ai]
synonym: "behavioural response to nutrient" EXACT []
is_a: GO:0007610 ! behavior
relationship: part_of GO:0007584 ! response to nutrient

[Term]
id: GO:0051781
name: positive regulation of cell division
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell division." [GOC:ai]
synonym: "activation of cell division" NARROW []
synonym: "stimulation of cell division" NARROW []
synonym: "up regulation of cell division" EXACT []
synonym: "up-regulation of cell division" EXACT []
synonym: "upregulation of cell division" EXACT []
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051302 ! regulation of cell division
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051301 ! cell division
relationship: positively_regulates GO:0051301 ! cell division

[Term]
id: GO:0051782
name: negative regulation of cell division
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell division." [GOC:ai]
synonym: "down regulation of cell division" EXACT []
synonym: "down-regulation of cell division" EXACT []
synonym: "downregulation of cell division" EXACT []
synonym: "inhibition of cell division" NARROW []
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051302 ! regulation of cell division
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051301 ! cell division
relationship: negatively_regulates GO:0051301 ! cell division

[Term]
id: GO:0051783
name: regulation of nuclear division
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." [GOC:ai]
is_a: GO:0033043 ! regulation of organelle organization
is_a: GO:0051302 ! regulation of cell division
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000280 ! nuclear division
relationship: regulates GO:0000280 ! nuclear division

[Term]
id: GO:0051784
name: negative regulation of nuclear division
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." [GOC:ai]
synonym: "down regulation of nuclear division" EXACT []
synonym: "down-regulation of nuclear division" EXACT []
synonym: "downregulation of nuclear division" EXACT []
synonym: "inhibition of nuclear division" NARROW []
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:0051782 ! negative regulation of cell division
is_a: GO:0051783 ! regulation of nuclear division
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000280 ! nuclear division
relationship: negatively_regulates GO:0000280 ! nuclear division

[Term]
id: GO:0051785
name: positive regulation of nuclear division
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." [GOC:ai]
synonym: "activation of nuclear division" NARROW []
synonym: "stimulation of nuclear division" NARROW []
synonym: "up regulation of nuclear division" EXACT []
synonym: "up-regulation of nuclear division" EXACT []
synonym: "upregulation of nuclear division" EXACT []
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:0051781 ! positive regulation of cell division
is_a: GO:0051783 ! regulation of nuclear division
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000280 ! nuclear division
relationship: positively_regulates GO:0000280 ! nuclear division

[Term]
id: GO:0051786
name: all-trans-retinol 13,14-reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH(2). Note that this reaction has only been observed to occur in the opposite direction." [EC:1.3.99.23, RHEA:19196]
synonym: "(13,14)-all-trans-retinol saturase activity" EXACT []
synonym: "all-trans-13,14-dihydroretinol:acceptor 13,14-oxidoreductase activity" EXACT []
synonym: "all-trans-retinol:all-trans-13,14-dihydroretinol saturase activity" EXACT []
synonym: "retinol saturase activity" EXACT [EC:1.3.99.23]
synonym: "RetSat activity" EXACT [EC:1.3.99.23]
xref: EC:1.3.99.23
xref: KEGG:R07163
xref: MetaCyc:1.3.99.23-RXN
xref: RHEA:19196
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors
relationship: part_of GO:0042572 ! retinol metabolic process

[Term]
id: GO:0051787
name: misfolded protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a misfolded protein." [GOC:ai]
xref: Reactome:REACT_25207 "Glycoproteins with major folding defects are sent to degradation by EDEMs, Homo sapiens"
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0051788
name: response to misfolded protein
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus." [GOC:go_curators]
is_a: GO:0035966 ! response to topologically incorrect protein

[Term]
id: GO:0051789
name: obsolete response to protein
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein stimulus." [GOC:ai]
comment: This term was made obsolete because more specific terms exist.
subset: gosubset_prok
synonym: "response to protein" EXACT []
synonym: "response to protein stimulus" EXACT [GOC:dos]
is_obsolete: true
consider: GO:0006986
consider: GO:0009725
consider: GO:0034097
consider: GO:0051788
consider: GO:0070848

[Term]
id: GO:0051790
name: short-chain fatty acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of fatty acids with a chain length of less than C6." [CHEBI:26666, GOC:go_curators]
synonym: "short chain fatty acid biosynthesis" EXACT []
synonym: "short chain fatty acid biosynthetic process" EXACT []
synonym: "short-chain fatty acid anabolism" EXACT []
synonym: "short-chain fatty acid biosynthesis" EXACT []
synonym: "short-chain fatty acid formation" EXACT []
synonym: "short-chain fatty acid synthesis" EXACT []
is_a: GO:0006633 ! fatty acid biosynthetic process
is_a: GO:0046459 ! short-chain fatty acid metabolic process

[Term]
id: GO:0051791
name: medium-chain fatty acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving medium-chain fatty acids, any fatty acid with a chain length of between C6 and C12." [CHEBI:59554, GOC:go_curators]
synonym: "medium chain fatty acid metabolic process" EXACT []
synonym: "medium chain fatty acid metabolism" EXACT []
synonym: "medium-chain fatty acid metabolism" EXACT []
is_a: GO:0006631 ! fatty acid metabolic process

[Term]
id: GO:0051792
name: medium-chain fatty acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any fatty acid with a chain length of between C6 and C12." [CHEBI:59554, GOC:ai]
synonym: "medium chain fatty acid biosynthesis" EXACT []
synonym: "medium chain fatty acid biosynthetic process" EXACT []
synonym: "medium-chain fatty acid anabolism" EXACT []
synonym: "medium-chain fatty acid biosynthesis" EXACT []
synonym: "medium-chain fatty acid formation" EXACT []
synonym: "medium-chain fatty acid synthesis" EXACT []
is_a: GO:0006633 ! fatty acid biosynthetic process
is_a: GO:0051791 ! medium-chain fatty acid metabolic process

[Term]
id: GO:0051793
name: medium-chain fatty acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any fatty acid with a chain length of between C6 and C12." [CHEBI:59554, GOC:ai]
synonym: "medium chain fatty acid catabolic process" EXACT []
synonym: "medium chain fatty acid catabolism" EXACT []
synonym: "medium-chain fatty acid breakdown" EXACT []
synonym: "medium-chain fatty acid catabolism" EXACT []
synonym: "medium-chain fatty acid degradation" EXACT []
is_a: GO:0009062 ! fatty acid catabolic process
is_a: GO:0051791 ! medium-chain fatty acid metabolic process

[Term]
id: GO:0051794
name: regulation of catagen
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of catagen, the regression phase of the hair cycle." [GOC:ai]
is_a: GO:0048819 ! regulation of hair follicle maturation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042637 ! catagen
relationship: regulates GO:0042637 ! catagen

[Term]
id: GO:0051795
name: positive regulation of catagen
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of catagen, the regression phase of the hair cycle." [GOC:ai]
synonym: "activation of catagen" NARROW []
synonym: "stimulation of catagen" NARROW []
synonym: "up regulation of catagen" EXACT []
synonym: "up-regulation of catagen" EXACT []
synonym: "upregulation of catagen" EXACT []
is_a: GO:0048818 ! positive regulation of hair follicle maturation
is_a: GO:0051794 ! regulation of catagen
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042637 ! catagen
relationship: positively_regulates GO:0042637 ! catagen

[Term]
id: GO:0051796
name: negative regulation of catagen
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of catagen, the regression phase of the hair cycle." [GOC:ai]
synonym: "down regulation of catagen" EXACT []
synonym: "down-regulation of catagen" EXACT []
synonym: "downregulation of catagen" EXACT []
synonym: "inhibition of catagen" NARROW []
is_a: GO:0048817 ! negative regulation of hair follicle maturation
is_a: GO:0051794 ! regulation of catagen
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042637 ! catagen
relationship: negatively_regulates GO:0042637 ! catagen

[Term]
id: GO:0051797
name: regulation of hair follicle development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hair follicle development." [GOC:ai]
is_a: GO:0042634 ! regulation of hair cycle
is_a: GO:0045682 ! regulation of epidermis development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001942 ! hair follicle development
relationship: regulates GO:0001942 ! hair follicle development

[Term]
id: GO:0051798
name: positive regulation of hair follicle development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hair follicle development." [GOC:ai]
synonym: "activation of hair follicle development" NARROW []
synonym: "stimulation of hair follicle development" NARROW []
synonym: "up regulation of hair follicle development" EXACT []
synonym: "up-regulation of hair follicle development" EXACT []
synonym: "upregulation of hair follicle development" EXACT []
is_a: GO:0042635 ! positive regulation of hair cycle
is_a: GO:0045684 ! positive regulation of epidermis development
is_a: GO:0051797 ! regulation of hair follicle development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001942 ! hair follicle development
relationship: positively_regulates GO:0001942 ! hair follicle development

[Term]
id: GO:0051799
name: negative regulation of hair follicle development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of hair follicle development." [GOC:ai]
synonym: "down regulation of hair follicle development" EXACT []
synonym: "down-regulation of hair follicle development" EXACT []
synonym: "downregulation of hair follicle development" EXACT []
synonym: "inhibition of hair follicle development" NARROW []
is_a: GO:0042636 ! negative regulation of hair cycle
is_a: GO:0045683 ! negative regulation of epidermis development
is_a: GO:0051797 ! regulation of hair follicle development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001942 ! hair follicle development
relationship: negatively_regulates GO:0001942 ! hair follicle development

[Term]
id: GO:0051800
name: phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphatidylinositol-3,4-bisphosphate + H2O = phosphatidylinositol-4-phosphate + phosphate." [GOC:bf, PMID:9811831]
synonym: "PTEN activity" BROAD []
is_a: GO:0034593 ! phosphatidylinositol bisphosphate phosphatase activity

[Term]
id: GO:0051801
name: cytolysis in other organism involved in symbiotic interaction
namespace: biological_process
def: "The killing by an organism of a cell in a second organism by means of the rupture of cell membranes and the loss of cytoplasm, where the two organisms are in a symbiotic interaction." [GOC:add]
subset: gosubset_prok
synonym: "cytolysis of cells in other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "cytolysis of cells in other organism involved in symbiotic interaction" EXACT [GOC:bf]
is_a: GO:0051715 ! cytolysis in other organism
is_a: GO:0051883 ! killing of cells in other organism involved in symbiotic interaction

[Term]
id: GO:0051802
name: regulation of cytolysis in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of the cytolysis by that organism of cells in a second organism, where the two organisms are in a symbiotic interaction." [GOC:add]
subset: gosubset_prok
synonym: "regulation of cytolysis of cells in other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "regulation of cytolysis of cells in other organism involved in symbiotic interaction" EXACT [GOC:bf]
is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism
is_a: GO:0051710 ! regulation of cytolysis in other organism
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051801 ! cytolysis in other organism involved in symbiotic interaction
relationship: regulates GO:0051801 ! cytolysis in other organism involved in symbiotic interaction

[Term]
id: GO:0051803
name: negative regulation of cytolysis in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of cytolysis by that organism of cells in a second organism, where the two organisms are in a symbiotic interaction." [GOC:add]
subset: gosubset_prok
synonym: "down regulation of cytolysis of cells in other organism during symbiotic interaction" RELATED []
synonym: "down-regulation of cytolysis of cells in other organism during symbiotic interaction" RELATED []
synonym: "downregulation of cytolysis of cells in other organism during symbiotic interaction" RELATED []
synonym: "inhibition of cytolysis of cells in other organism during symbiotic interaction" NARROW []
synonym: "negative regulation of cytolysis of cells in other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "negative regulation of cytolysis of cells in other organism involved in symbiotic interaction" EXACT [GOC:bf]
is_a: GO:0051713 ! negative regulation of cytolysis in other organism
is_a: GO:0051802 ! regulation of cytolysis in other organism involved in symbiotic interaction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051801 ! cytolysis in other organism involved in symbiotic interaction
relationship: negatively_regulates GO:0051801 ! cytolysis in other organism involved in symbiotic interaction

[Term]
id: GO:0051804
name: positive regulation of cytolysis in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism activates or increases the frequency, rate or extent of cytolysis by that organism of cells in a second organism, where the two organisms are in a symbiotic interaction." [GOC:add]
subset: gosubset_prok
synonym: "activation of cytolysis of cells in other organism during symbiotic interaction" NARROW []
synonym: "positive regulation of cytolysis of cells in other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "positive regulation of cytolysis of cells in other organism involved in symbiotic interaction" EXACT [GOC:bf]
synonym: "stimulation of cytolysis of cells in other organism during symbiotic interaction" NARROW []
synonym: "up regulation of cytolysis of cells in other organism during symbiotic interaction" EXACT []
synonym: "up-regulation of cytolysis of cells in other organism during symbiotic interaction" EXACT []
synonym: "upregulation of cytolysis of cells in other organism during symbiotic interaction" EXACT []
is_a: GO:0051714 ! positive regulation of cytolysis in other organism
is_a: GO:0051802 ! regulation of cytolysis in other organism involved in symbiotic interaction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051801 ! cytolysis in other organism involved in symbiotic interaction
relationship: positively_regulates GO:0051801 ! cytolysis in other organism involved in symbiotic interaction

[Term]
id: GO:0051805
name: evasion or tolerance of immune response of other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism avoids the immune response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mb]
subset: gosubset_prok
synonym: "evasion or tolerance of immune response of other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "immune evasion" EXACT []
is_a: GO:0051807 ! evasion or tolerance of defense response of other organism involved in symbiotic interaction
is_a: GO:0052564 ! response to immune response of other organism involved in symbiotic interaction

[Term]
id: GO:0051806
name: entry into cell of other organism involved in symbiotic interaction
namespace: biological_process
def: "The invasion by an organism of a cell of a second organism, where the two organisms are in a symbiotic interaction." [GOC:njm]
subset: gosubset_prok
synonym: "entry into cell of other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "other organism cell invasion" EXACT []
is_a: GO:0051828 ! entry into other organism involved in symbiotic interaction

[Term]
id: GO:0051807
name: evasion or tolerance of defense response of other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process, either active or passive, by which an organism avoids or tolerates the effects of a second organism's defense response; the defense response is mounted by the second organism in response to the presence of the first organism, where the two organisms are in a symbiotic interaction." [GOC:mah]
subset: gosubset_prok
synonym: "evasion of other organism defence response" EXACT []
synonym: "evasion or tolerance of defense response of other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0051834 ! evasion or tolerance of defenses of other organism involved in symbiotic interaction

[Term]
id: GO:0051808
name: translocation of peptides or proteins into other organism involved in symbiotic interaction
namespace: biological_process
def: "The directed movement of peptides or proteins produced by an organism to a location inside a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
synonym: "translocation of peptides or proteins into other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "transport of peptides or proteins into other organism during symbiotic interaction" RELATED []
is_a: GO:0015031 ! protein transport
is_a: GO:0051836 ! translocation of molecules into other organism involved in symbiotic interaction

[Term]
id: GO:0051809
name: passive evasion of immune response of other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism avoids the immune response of a second organism without directly interfering with the second organism's immune system, where the two organisms are in a symbiotic interaction." [PMID:12439615]
subset: gosubset_prok
synonym: "passive evasion of immune response of other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "passive immune evasion" EXACT []
is_a: GO:0051805 ! evasion or tolerance of immune response of other organism involved in symbiotic interaction

[Term]
id: GO:0051810
name: active evasion of immune response of other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism avoids the immune response of a second organism which directly affects the second organism's immune system, where the two organisms are in a symbiotic interaction." [PMID:12439615]
subset: gosubset_prok
synonym: "active evasion of immune response of other organism during symbiotic interaction" RELATED [GOC:dph, GOC:tb]
synonym: "active immune evasion" EXACT []
is_a: GO:0051805 ! evasion or tolerance of immune response of other organism involved in symbiotic interaction

[Term]
id: GO:0051811
name: active evasion of immune response of other organism via regulation of complement system of other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism avoids the immune response of a second organism by regulating the second organism's complement system, where the two organisms are in a symbiotic interaction." [http://www.brown.edu/Courses/Bio_160/Projects1999/ies/ces.html]
synonym: "active evasion of immune response of other organism via regulation of complement system of other organism during symbiotic interaction" RELATED [GOC:dph, GOC:tb]
synonym: "active immune evasion via modulation of complement system of other organism" EXACT []
synonym: "active immune evasion via regulation of complement system of other organism" EXACT []
is_a: GO:0051810 ! active evasion of immune response of other organism involved in symbiotic interaction

[Term]
id: GO:0051812
name: active evasion of immune response of other organism via regulation of cytokine network of other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism avoids the immune response of a second organism by regulating the second organism's cytokine networks, where the two organisms are in a symbiotic interaction." [http://www.brown.edu/Courses/Bio_160/Projects1999/ies/cytok.html#Manipulation]
synonym: "active evasion of immune response of other organism via regulation of cytokine network of other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "active immune evasion via modulation of cytokine network of other organism" EXACT []
synonym: "active immune evasion via regulation of cytokine network of other organism" EXACT []
is_a: GO:0051810 ! active evasion of immune response of other organism involved in symbiotic interaction

[Term]
id: GO:0051813
name: active evasion of immune response of other organism via regulation of antigen processing and presentation in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism avoids the immune response of a second organism by regulating the second organism's antigen processing or presentation pathways, where the two organisms are in a symbiotic interaction." [PMID:12439615]
synonym: "active evasion of immune response of other organism via regulation of antigen processing and presentation in other organism during symbiotic interaction" RELATED [GOC:dph, GOC:tb]
synonym: "active evasion of immune response of other organism via regulation of antigen processing and presentation pathway in other organism during symbiotic interaction" EXACT []
synonym: "active immune evasion via modulation of antigen processing and presentation in other organism" EXACT []
synonym: "active immune evasion via modulation of antigen processing/presentation in other organism" EXACT []
synonym: "active immune evasion via regulation of antigen processing and presentation in other organism" EXACT []
is_a: GO:0042786 ! active evasion of host immune response via regulation of host antigen processing and presentation

[Term]
id: GO:0051814
name: movement in other organism involved in symbiotic interaction
namespace: biological_process
def: "The process in which an organism or its progeny spreads from one location to another within a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
synonym: "movement in other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "movement within other organism during symbiotic interaction" EXACT []
is_a: GO:0052192 ! movement in environment of other organism involved in symbiotic interaction

[Term]
id: GO:0051815
name: migration in other organism involved in symbiotic interaction
namespace: biological_process
def: "The directional movement of an organism from one place to another within a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
synonym: "migration in other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "migration within other organism during symbiotic interaction" RELATED []
is_a: GO:0051814 ! movement in other organism involved in symbiotic interaction

[Term]
id: GO:0051816
name: acquisition of nutrients from other organism during symbiotic interaction
namespace: biological_process
def: "The production of structures and/or molecules in an organism that are required for the acquisition and/or utilization of nutrients obtained from a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
is_a: GO:0051704 ! multi-organism process
relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism

[Term]
id: GO:0051817
name: modification of morphology or physiology of other organism involved in symbiotic interaction
namespace: biological_process
def: "The process in which an organism effects a change in the structure or processes of a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
synonym: "modification of morphology or physiology of other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "modulation of morphology or physiology of other organism during symbiotic interaction" RELATED []
synonym: "regulation of morphology of other organism during symbiotic interaction" NARROW []
synonym: "regulation of morphology or physiology of other organism during symbiotic interaction" RELATED []
synonym: "regulation of physiological process in other organism during symbiotic interaction" NARROW []
synonym: "regulation of physiology of other organism during symbiotic interaction" NARROW []
is_a: GO:0035821 ! modification of morphology or physiology of other organism
intersection_of: GO:0035821 ! modification of morphology or physiology of other organism
intersection_of: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism
relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism

[Term]
id: GO:0051818
name: disruption of cells of other organism involved in symbiotic interaction
namespace: biological_process
def: "A process in which an organism has a negative effect on the functioning of the second organism's cells, where the two organisms are in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
synonym: "disruption of cells of other organism during symbiotic interaction" RELATED [GOC:tb]
is_a: GO:0044364 ! disruption of cells of other organism
is_a: GO:0051817 ! modification of morphology or physiology of other organism involved in symbiotic interaction

[Term]
id: GO:0051819
name: induction of tumor, nodule, or growth in other organism involved in symbiotic interaction
namespace: biological_process
def: "The process in which an organism causes the formation of a mass of cells in a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
synonym: "induction of tumor, nodule, or growth in other organism during symbiotic interaction" RELATED [GOC:tb]
is_a: GO:0051817 ! modification of morphology or physiology of other organism involved in symbiotic interaction

[Term]
id: GO:0051820
name: induction of tumor, nodule, or growth containing transformed cells in other organism involved in symbiotic interaction
namespace: biological_process
def: "The process in which an organism causes the formation in a second organism of a growth whose cells have been transformed and continue to exist in the absence of the first organism, where the two organisms are in a symbiotic interaction." [GOC:cc]
synonym: "induction of tumor, nodule, or growth containing transformed cells in other organism during symbiotic interaction" RELATED [GOC:tb]
is_a: GO:0051819 ! induction of tumor, nodule, or growth in other organism involved in symbiotic interaction

[Term]
id: GO:0051821
name: dissemination or transmission of organism from other organism involved in symbiotic interaction
namespace: biological_process
def: "The movement of an organism from a second organism to another place in the environment, where the two organisms are in a symbiotic interaction. The first organism may also move to a different organism." [GOC:cc]
subset: gosubset_prok
synonym: "dissemination or transmission of organism from other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0040011 ! locomotion
relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism

[Term]
id: GO:0051822
name: dissemination or transmission of organism from other organism by vector involved in symbiotic interaction
namespace: biological_process
def: "The movement of an organism from a second organism to another place in the environment by means of a vector, where the two organisms are in a symbiotic interaction. The first organism may also move to a different organism, and the vector organism is often an insect or an animal." [GOC:cc]
subset: gosubset_prok
synonym: "dissemination or transmission of organism from other organism by vector during symbiotic interaction" RELATED [GOC:tb]
is_a: GO:0051821 ! dissemination or transmission of organism from other organism involved in symbiotic interaction

[Term]
id: GO:0051823
name: regulation of synapse structural plasticity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synapse structural plasticity. Synapse structural plasticity is a type of cytoskeletal remodeling; this remodeling is induced by stimuli that can lead to long term potentiation and it can be activity-dependent or -independent. Examples of cytoskeletal changes include the formation of new spines and increase in spine size; this can be accompanied by the insertion of greater numbers of glutamate (or other neurotransmitter) receptors into the post-synaptic membrane." [PMID:11063967, PMID:14976517, PMID:9884123]
synonym: "regulation of synaptic structural plasticity" EXACT []
is_a: GO:0050807 ! regulation of synapse organization

[Term]
id: GO:0051824
name: recognition of other organism involved in symbiotic interaction
namespace: biological_process
def: "The set of specific processes that allow an organism to detect the presence of a second organism via physical or chemical signals, where the two organisms are in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
synonym: "recognition of other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0098543 ! detection of other organism
relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism

[Term]
id: GO:0051826
name: negative regulation of synapse structural plasticity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of synapse structural plasticity." [GOC:ai]
synonym: "down regulation of synapse structural plasticity" EXACT []
synonym: "down-regulation of synapse structural plasticity" EXACT []
synonym: "downregulation of synapse structural plasticity" EXACT []
synonym: "inhibition of synapse structural plasticity" NARROW []
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:0051823 ! regulation of synapse structural plasticity

[Term]
id: GO:0051827
name: obsolete growth or development on or near surface of other organism during symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring on or near the exterior of a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc]
comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'growth on or near surface of other organism during symbiotic interaction ; GO:0044153' and 'development on or near surface of other organism during symbiotic interaction ; GO:0044152'.
subset: gosubset_prok
synonym: "growth or development on or near surface of other organism during symbiotic interaction" EXACT []
is_obsolete: true
consider: GO:0044152
consider: GO:0044153

[Term]
id: GO:0051828
name: entry into other organism involved in symbiotic interaction
namespace: biological_process
def: "Penetration by an organism into the body, tissues, or cells of a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
synonym: "entry into other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "invasion into other organism" EXACT []
synonym: "invasion of other organism" EXACT []
synonym: "invasive growth" RELATED []
synonym: "other organism invasion" EXACT []
is_a: GO:0052192 ! movement in environment of other organism involved in symbiotic interaction

[Term]
id: GO:0051829
name: entry into other organism through natural portals involved in symbiotic interaction
namespace: biological_process
def: "Penetration by an organism into a second organism via naturally occurring openings in the second organism, where the two organisms are in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
synonym: "entry into other organism through natural portals during symbiotic interaction" RELATED [GOC:tb]
is_a: GO:0051828 ! entry into other organism involved in symbiotic interaction

[Term]
id: GO:0051830
name: entry into other organism through barriers of other organism involved in symbiotic interaction
namespace: biological_process
def: "Penetration by an organism into a second organism via active breaching of physical barriers, where the two organisms are in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
synonym: "entry into other organism through barriers of other organism during symbiotic interaction" RELATED [GOC:tb]
is_a: GO:0051828 ! entry into other organism involved in symbiotic interaction

[Term]
id: GO:0051831
name: obsolete growth or development in other organism during symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring within the cells or tissues of a second organism, where the two organisms are in a symbiotic interaction. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down the tissue of the second organism." [GOC:cc]
comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'growth in other organism during symbiotic interaction ; GO:0044112' and 'development in other organism during symbiotic interaction ; GO:0044113'.
subset: gosubset_prok
synonym: "growth or development in other organism during symbiotic interaction" EXACT []
synonym: "growth or development within other organism during symbiotic interaction" EXACT []
synonym: "invasive growth" BROAD []
is_obsolete: true
consider: GO:0044112
consider: GO:0044113

[Term]
id: GO:0051832
name: avoidance of defenses of other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process, either constitutive or induced, by which an organism evades, minimizes, or suppresses the effects of a second organism's defense(s), where the two organisms are in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
synonym: "avoidance of defenses of other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0052173 ! response to defenses of other organism involved in symbiotic interaction

[Term]
id: GO:0051833
name: suppression of defenses of other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the defense(s) of a second organism, where the two organisms are in a symbiotic interaction. Suppression occurs by active mechanisms that normally result in the shutting down of pathways in the second organism." [GOC:cc]
subset: gosubset_prok
synonym: "negative regulation of defenses of other organism during symbiotic interaction" RELATED []
synonym: "suppression of defenses of other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0051832 ! avoidance of defenses of other organism involved in symbiotic interaction

[Term]
id: GO:0051834
name: evasion or tolerance of defenses of other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process, either active or passive, by which an organism avoids or tolerates the effects of a second organism's defense(s), where the two organisms are in a symbiotic interaction. Defenses may be induced by the presence of the organism or may be preformed (e.g. physical barriers)." [GOC:cc]
subset: gosubset_prok
synonym: "evasion or tolerance of defenses of other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0051832 ! avoidance of defenses of other organism involved in symbiotic interaction

[Term]
id: GO:0051835
name: positive regulation of synapse structural plasticity
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of synaptic structural plasticity." [GOC:ai]
synonym: "activation of synapse structural plasticity" NARROW []
synonym: "stimulation of synapse structural plasticity" NARROW []
synonym: "up regulation of synapse structural plasticity" EXACT []
synonym: "up-regulation of synapse structural plasticity" EXACT []
synonym: "upregulation of synapse structural plasticity" EXACT []
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:0051823 ! regulation of synapse structural plasticity

[Term]
id: GO:0051836
name: translocation of molecules into other organism involved in symbiotic interaction
namespace: biological_process
def: "The directed movement of a molecule(s) produced by an organism to a location inside a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
synonym: "translocation of molecules into other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "transport of molecules into other organism during symbiotic interaction" RELATED []
is_a: GO:0044766 ! multi-organism transport
relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism

[Term]
id: GO:0051837
name: translocation of DNA into other organism involved in symbiotic interaction
namespace: biological_process
def: "The directed movement of DNA from an organism to a location inside a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc]
synonym: "translocation of DNA into other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "transport of DNA into other organism during symbiotic interaction" RELATED []
is_a: GO:0051027 ! DNA transport
is_a: GO:0051836 ! translocation of molecules into other organism involved in symbiotic interaction

[Term]
id: GO:0051838
name: cytolysis by host of symbiont cells
namespace: biological_process
def: "The killing by an organism of a cell in its symbiont organism by means of the rupture of cell membranes and the loss of cytoplasm. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:add]
subset: gosubset_prok
is_a: GO:0051801 ! cytolysis in other organism involved in symbiotic interaction
is_a: GO:0051873 ! killing by host of symbiont cells
relationship: has_part GO:0052337 ! modification by host of symbiont membrane

[Term]
id: GO:0051839
name: regulation by host of cytolysis of symbiont cells
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of the cytolysis by that organism of cells in its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:add]
subset: gosubset_prok
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0032101 ! regulation of response to external stimulus
is_a: GO:0051802 ! regulation of cytolysis in other organism involved in symbiotic interaction
relationship: regulates GO:0051838 ! cytolysis by host of symbiont cells

[Term]
id: GO:0051840
name: negative regulation by host of cytolysis of symbiont cells
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of cytolysis by that organism of cells in its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:add]
subset: gosubset_prok
synonym: "down regulation by host of cytolysis of symbiont cells" EXACT []
synonym: "down-regulation by host of cytolysis of symbiont cells" EXACT []
synonym: "downregulation by host of cytolysis of symbiont cells" EXACT []
synonym: "inhibition by host of cytolysis of symbiont cells" NARROW []
is_a: GO:0051803 ! negative regulation of cytolysis in other organism involved in symbiotic interaction
is_a: GO:0051839 ! regulation by host of cytolysis of symbiont cells

[Term]
id: GO:0051841
name: positive regulation by host of cytolysis of symbiont cells
namespace: biological_process
def: "Any process in which an organism activates or increases the frequency, rate or extent of cytolysis by that organism of cells in its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:add]
subset: gosubset_prok
synonym: "activation by host of cytolysis of symbiont cells" NARROW []
synonym: "stimulation by host of cytolysis of symbiont cells" NARROW []
synonym: "up regulation by host of cytolysis of symbiont cells" EXACT []
synonym: "up-regulation by host of cytolysis of symbiont cells" EXACT []
synonym: "upregulation by host of cytolysis of symbiont cells" EXACT []
is_a: GO:0051804 ! positive regulation of cytolysis in other organism involved in symbiotic interaction
is_a: GO:0051839 ! regulation by host of cytolysis of symbiont cells

[Term]
id: GO:0051842
name: obsolete evasion or tolerance of symbiont immune response
namespace: biological_process
def: "OBSOLETE. Any process, either active or passive, by which an organism avoids the effects of the symbiont organism's immune response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mb]
comment: This term was made obsolete because it does not represent a valid biological process that occurs in nature.
synonym: "evasion or tolerance of symbiont immune response" EXACT []
synonym: "immune evasion" BROAD []
is_obsolete: true

[Term]
id: GO:0051843
name: obsolete evasion or tolerance of symbiont defense response
namespace: biological_process
def: "OBSOLETE. Any process, either active or passive, by which an organism avoids or tolerates the effects of a symbiont organism's defense response. The symbiont defense response is mounted by the symbiont in response to the presence of the organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mah]
comment: This term was made obsolete because it does not represent a real process that exists in nature.
synonym: "evasion of symbiont defence response" EXACT []
synonym: "evasion or tolerance of symbiont defense response" EXACT []
is_obsolete: true

[Term]
id: GO:0051844
name: translocation of peptides or proteins into symbiont
namespace: biological_process
def: "The directed movement of peptides or proteins produced by an organism to a location inside the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
synonym: "transport of peptides or proteins into symbiont" EXACT []
is_a: GO:0051808 ! translocation of peptides or proteins into other organism involved in symbiotic interaction
is_a: GO:0051862 ! translocation of molecules into symbiont

[Term]
id: GO:0051845
name: obsolete passive evasion of symbiont immune response
namespace: biological_process
def: "OBSOLETE. Any mechanism of immune avoidance that does not directly interfere with the symbiont immune system. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [PMID:12439615]
comment: This term was made obsolete because it does not represent a real process that exists in nature.
synonym: "passive evasion of symbiont immune response" EXACT []
synonym: "passive immune evasion" BROAD []
is_obsolete: true

[Term]
id: GO:0051846
name: obsolete active evasion of symbiont immune response
namespace: biological_process
def: "OBSOLETE. Any mechanism of immune avoidance that directly affects the symbiont immune system, e.g. blocking any stage in symbiont MHC class I and II presentation. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [PMID:12439615]
comment: This term was made obsolete because it does not represent a real process that exists in nature.
synonym: "active evasion of symbiont immune response" EXACT []
synonym: "active immune evasion" BROAD []
is_obsolete: true

[Term]
id: GO:0051847
name: obsolete active evasion of symbiont immune response via regulation of symbiont complement system
namespace: biological_process
def: "OBSOLETE. Any mechanism of active immune avoidance which works by regulating the symbiont complement system, e.g. by possessing complement receptors which mediate attachment to, then infection of, symbiont macrophages, which are eventually destroyed. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [http://www.brown.edu/Courses/Bio_160/Projects1999/ies/ces.html]
comment: This term was made obsolete because it does not represent a real process that exists in nature.
synonym: "active evasion of symbiont immune response via regulation of symbiont complement system" EXACT []
synonym: "active immune evasion via modulation of symbiont complement system" EXACT []
synonym: "active immune evasion via regulation of symbiont complement system" EXACT []
is_obsolete: true

[Term]
id: GO:0051848
name: obsolete active evasion of symbiont immune response via regulation of symbiont cytokine network
namespace: biological_process
def: "OBSOLETE. Any mechanism of active immune avoidance which works by regulating symbiont cytokine networks, e.g. by secreting proteins that mimic cytokine receptors that act to sequester symbiont cytokines and inhibit action. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [http://www.brown.edu/Courses/Bio_160/Projects1999/ies/cytok.html#Manipulation]
comment: This term was made obsolete because it does not represent a real process that exists in nature.
synonym: "active evasion of symbiont immune response via regulation of symbiont cytokine network" EXACT []
synonym: "active immune evasion via modulation of symbiont cytokine network" EXACT []
synonym: "active immune evasion via regulation of symbiont cytokine network" EXACT []
is_obsolete: true

[Term]
id: GO:0051849
name: obsolete active evasion of symbiont immune response via regulation of symbiont antigen processing and presentation
namespace: biological_process
def: "OBSOLETE. Any mechanism of active immune avoidance which works by regulating the symbiont's antigen processing or presentation pathways, e.g. by blocking any stage in MHC class II presentation. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [PMID:12439615]
comment: This term was made obsolete because it does not represent a real process that exists in nature.
synonym: "active evasion of symbiont immune response via regulation of symbiont antigen processing and presentation" EXACT []
synonym: "active evasion of symbiont immune response via regulation of symbiont antigen processing and presentation pathway" EXACT []
synonym: "active immune evasion via modulation of symbiont antigen processing and presentation" EXACT []
synonym: "active immune evasion via modulation of symbiont antigen processing/presentation" EXACT []
synonym: "active immune evasion via regulation of symbiont antigen processing or presentation" EXACT []
is_obsolete: true

[Term]
id: GO:0051850
name: acquisition of nutrients from symbiont
namespace: biological_process
def: "The production of structures and/or molecules in an organism that are required for the acquisition and/or utilization of nutrients obtained from its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
is_a: GO:0051702 ! interaction with symbiont
is_a: GO:0051816 ! acquisition of nutrients from other organism during symbiotic interaction

[Term]
id: GO:0051851
name: modification by host of symbiont morphology or physiology
namespace: biological_process
def: "The process in which an organism effects a change in the structure or processes of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
is_a: GO:0051702 ! interaction with symbiont
is_a: GO:0051817 ! modification of morphology or physiology of other organism involved in symbiotic interaction

[Term]
id: GO:0051852
name: disruption by host of symbiont cells
namespace: biological_process
def: "Any process in which an organism has a negative effect on the functioning of the symbiont's cells. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
is_a: GO:0051818 ! disruption of cells of other organism involved in symbiotic interaction
is_a: GO:0051851 ! modification by host of symbiont morphology or physiology
is_a: GO:0098542 ! defense response to other organism

[Term]
id: GO:0051853
name: obsolete induction in symbiont of tumor, nodule, or growth
namespace: biological_process
def: "OBSOLETE. The process by which an associated organism causes the formation of an abnormal mass of cells in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc]
comment: This term was made obsolete because it does not represent a real process that exists in nature.
synonym: "induction in symbiont of tumor, nodule, or growth" EXACT []
is_obsolete: true

[Term]
id: GO:0051854
name: obsolete induction in symbiont of tumor, nodule, or growth containing transformed cells
namespace: biological_process
def: "OBSOLETE. The process by which an organism causes the formation in its symbiont organism of an abnormal growth whose cells have been transformed and continue to exist in the absence of the first organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc]
comment: This term was made obsolete because it does not represent a real process that exists in nature.
synonym: "induction in symbiont of tumor, nodule, or growth containing transformed cells" EXACT []
is_obsolete: true

[Term]
id: GO:0051855
name: recognition of symbiont
namespace: biological_process
def: "The set of specific processes that allow an organism to detect the presence of its symbiont via physical or chemical signals. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
is_a: GO:0009602 ! detection of symbiont
is_a: GO:0051702 ! interaction with symbiont
is_a: GO:0051824 ! recognition of other organism involved in symbiotic interaction

[Term]
id: GO:0051857
name: obsolete growth or development of organism on or near symbiont surface
namespace: biological_process
def: "OBSOLETE. The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring on or near the exterior of its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc]
comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'growth of organism on or near symbiont surface ; GO:0044151' and 'development of organism on or near symbiont surface ; GO:0044150'.
subset: gosubset_prok
synonym: "growth or development of organism during interaction with symbiont" EXACT []
synonym: "growth or development of organism on or near symbiont surface" EXACT []
is_obsolete: true
consider: GO:0044150
consider: GO:0044151

[Term]
id: GO:0051858
name: avoidance of symbiont defenses
namespace: biological_process
def: "Any process, either constitutive or induced, by which an organism evades, minimizes, or suppresses the effects of its symbiont organism's defense(s). The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
is_a: GO:0051702 ! interaction with symbiont
is_a: GO:0051832 ! avoidance of defenses of other organism involved in symbiotic interaction
is_a: GO:0052201 ! response to symbiont defenses

[Term]
id: GO:0051859
name: suppression of symbiont defenses
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of symbiont defense(s) by active mechanisms that normally result in the shutting down of a symbiont pathway. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
is_a: GO:0051833 ! suppression of defenses of other organism involved in symbiotic interaction
is_a: GO:0051858 ! avoidance of symbiont defenses

[Term]
id: GO:0051860
name: evasion or tolerance of symbiont defenses
namespace: biological_process
def: "The process, either active or passive, by which an organism evades or tolerates the effects of the defense(s) or defense molecules of a symbiont organism. Symbiont defenses may be induced by the presence of the organism or may be preformed (e.g. physical barriers). The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
is_a: GO:0051834 ! evasion or tolerance of defenses of other organism involved in symbiotic interaction
is_a: GO:0051858 ! avoidance of symbiont defenses

[Term]
id: GO:0051861
name: glycolipid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic group such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate." [http://www.chem.qmul.ac.uk/iupac/misc/glylp.html#2.1]
is_a: GO:0008289 ! lipid binding
is_a: GO:0097367 ! carbohydrate derivative binding

[Term]
id: GO:0051862
name: translocation of molecules into symbiont
namespace: biological_process
def: "The directed movement of molecule(s) produced by an organism to a location inside the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
synonym: "transport of molecules into symbiont" EXACT []
is_a: GO:0051702 ! interaction with symbiont
is_a: GO:0051836 ! translocation of molecules into other organism involved in symbiotic interaction

[Term]
id: GO:0051863
name: obsolete translocation of DNA into symbiont
namespace: biological_process
def: "OBSOLETE. The directed movement of DNA from an organism to a location inside the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc]
comment: This term was made obsolete because it does not represent a real process that exists in nature.
synonym: "translocation of DNA into symbiont" EXACT []
is_obsolete: true

[Term]
id: GO:0051864
name: histone demethylase activity (H3-K36 specific)
namespace: molecular_function
def: "Catalysis of the reaction: histone H3 N6-methyl-L-lysine (position 36) + alpha-ketoglutarate + O2 = succinate + CO2 + formaldehyde + lysine. This reaction is the removal of a methyl group from lysine at position 36 of the histone H3 protein." [PMID:16362057]
synonym: "[histone-H3]-lysine-36 demethylase activity" EXACT []
synonym: "H3-K36-specific demethylase activity" EXACT [EC:1.14.11.27]
synonym: "histone H3-lysine-36 demethylase activity" EXACT [EC:1.14.11.27]
synonym: "histone-lysine (H3-K36) demethylase activity" EXACT [EC:1.14.11.27]
synonym: "histone-lysine demethylase activity (H3-K36 specific)" EXACT []
synonym: "histone-lysine(H3-K36) demethylase activity" EXACT []
synonym: "JHDM1A activity" NARROW [EC:1.14.11.27]
synonym: "JmjC domain-containing histone demethylase 1A activity" NARROW [EC:1.14.11.27]
synonym: "protein-6-N,6-N-dimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase activity" EXACT [EC:1.14.11.27]
synonym: "protein-N6,N6-dimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase activity" EXACT [EC:1.14.11.27]
xref: EC:1.14.11.27
xref: MetaCyc:RXN-8660
xref: MetaCyc:RXN-8661
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
is_a: GO:0032452 ! histone demethylase activity
relationship: part_of GO:0070544 ! histone H3-K36 demethylation

[Term]
id: GO:0051865
name: protein autoubiquitination
namespace: biological_process
def: "The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink." [GOC:ai]
synonym: "protein auto-ubiquitination" EXACT []
synonym: "protein auto-ubiquitinylation" EXACT []
synonym: "protein autoubiquitinylation" EXACT []
synonym: "protein self-ubiquitination" EXACT []
synonym: "protein self-ubiquitinylation" EXACT []
is_a: GO:0016567 ! protein ubiquitination

[Term]
id: GO:0051866
name: general adaptation syndrome
namespace: biological_process
alt_id: GO:0051868
def: "General adaptation syndrome is the set of changes in various organ systems of the body, especially the pituitary-endocrine system, in response to a wide range of strong external stimuli, both physiological and psychological. It is described as having three stages: alarm reaction, where the body detects the external stimulus; adaptation, where the body engages defensive countermeasures against the stressor; and exhaustion, where the body begins to run out of defenses." [http://www.onelook.com, PMID:14847556, Wikipedia:General_adaptation_syndrome]
synonym: "general adaptation syndrome, physiological process" EXACT []
synonym: "general adaptation syndrome, physiological response" EXACT []
synonym: "physiological process during general adaptation syndrome" EXACT []
synonym: "physiological response during general adaptation syndrome" EXACT []
is_a: GO:0033555 ! multicellular organismal response to stress

[Term]
id: GO:0051867
name: general adaptation syndrome, behavioral process
namespace: biological_process
def: "The set of behavioral processes that occur as part of the general adaptation syndrome, the response of the body to a strong, stressful stimulus." [GOC:ai]
synonym: "behavioral process during general adaptation syndrome" EXACT []
synonym: "behavioral response during general adaptation syndrome" EXACT []
synonym: "behavioural process during general adaptation syndrome" EXACT []
synonym: "behavioural response during general adaptation syndrome" EXACT []
synonym: "general adaptation syndrome, behavioral response" EXACT []
synonym: "general adaptation syndrome, behavioural process" EXACT []
synonym: "general adaptation syndrome, behavioural response" EXACT []
is_a: GO:0044708 ! single-organism behavior
relationship: part_of GO:0051866 ! general adaptation syndrome

[Term]
id: GO:0051870
name: methotrexate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with methotrexate, an antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofolate reductase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA." [GOC:nln]
subset: gosubset_prok
is_a: GO:0008144 ! drug binding
is_a: GO:0031406 ! carboxylic acid binding
is_a: GO:0033218 ! amide binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding

[Term]
id: GO:0051871
name: dihydrofolic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with dihydrofolic acid, a folic acid in which the bicyclic pteridine structure is in the dihydro, partially reduced form; they are intermediates in folate metabolism and are reduced to their tetrahydro, reduced forms." [ISBN:0721662544]
synonym: "DHF binding" RELATED []
synonym: "dihydrofolate binding" RELATED []
is_a: GO:0016597 ! amino acid binding
is_a: GO:0033218 ! amide binding
is_a: GO:0072341 ! modified amino acid binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding

[Term]
id: GO:0051872
name: sphingosine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues." [GOC:ai]
synonym: "(4E)-sphing-4-enine catabolic process" EXACT []
synonym: "(4E)-sphing-4-enine catabolism" EXACT []
synonym: "sphing-4-enine catabolic process" EXACT []
synonym: "sphing-4-enine catabolism" EXACT []
is_a: GO:0006670 ! sphingosine metabolic process
is_a: GO:0034313 ! diol catabolic process
is_a: GO:0046521 ! sphingoid catabolic process

[Term]
id: GO:0051873
name: killing by host of symbiont cells
namespace: biological_process
def: "Any process mediated by an organism that results in the death of cells in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:add]
subset: gosubset_prok
is_a: GO:0051852 ! disruption by host of symbiont cells
is_a: GO:0051883 ! killing of cells in other organism involved in symbiotic interaction

[Term]
id: GO:0051874
name: sphinganine-1-phosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of sphinganine-1-phosphate, the phosphorylated derivative of D-erythro-2-amino-1,3-octadecanediol." [GOC:ai]
synonym: "dihydrosphingosine-1-phosphate catabolic process" EXACT []
synonym: "dihydrosphingosine-1-phosphate catabolism" EXACT []
is_a: GO:0006668 ! sphinganine-1-phosphate metabolic process
is_a: GO:0009395 ! phospholipid catabolic process
is_a: GO:0030149 ! sphingolipid catabolic process

[Term]
id: GO:0051875
name: pigment granule localization
namespace: biological_process
def: "Any process in which a pigment granule is transported to, and/or maintained in, a specific location within the cell." [GOC:ai]
synonym: "pigment granule localisation" EXACT [GOC:mah]
is_a: GO:0051648 ! vesicle localization
relationship: part_of GO:0033059 ! cellular pigmentation

[Term]
id: GO:0051876
name: pigment granule dispersal
namespace: biological_process
def: "The directed movement of pigment granules within a cell towards the cell periphery." [GOC:mh]
is_a: GO:0051905 ! establishment of pigment granule localization

[Term]
id: GO:0051877
name: pigment granule aggregation in cell center
namespace: biological_process
def: "The directed movement of dispersed pigment granules towards the center of the cell." [GOC:mh]
is_a: GO:0051905 ! establishment of pigment granule localization

[Term]
id: GO:0051878
name: lateral element assembly
namespace: biological_process
def: "The cell cycle process in which lateral elements are formed. Axial elements form a proteinaceous core between the two sister chromatids of each chromosome; the two axial elements then connect along their entire lengths by fine fibers known as transverse filaments, forming the lateral elements." [PMID:11463847]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0007130 ! synaptonemal complex assembly

[Term]
id: GO:0051879
name: Hsp90 protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size." [GOC:ai]
synonym: "Hsp90 binding" EXACT []
synonym: "Hsp90 class protein binding" EXACT []
is_a: GO:0031072 ! heat shock protein binding

[Term]
id: GO:0051880
name: G-quadruplex DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad. The stacking of guanine tetrads results in G-quadruplex DNA structures. G-quadruplex DNA can form under physiological conditions from some G-rich sequences, such as those found in telomeres, immunoglobulin switch regions, gene promoters, fragile X repeats, and the dimerization domain in the human immunodeficiency virus (HIV) genome." [PMID:16142245, PMID:9512530]
synonym: "G quadruplex DNA binding" EXACT [GOC:mah]
synonym: "G quartet binding" BROAD [GOC:mah]
synonym: "G quartet DNA binding" EXACT [GOC:mah]
synonym: "G-DNA binding" EXACT []
synonym: "G-quartet binding" BROAD [GOC:mah]
synonym: "G-quartet DNA binding" EXACT [GOC:mah]
synonym: "quadruplex DNA binding" EXACT []
synonym: "tetraplex DNA binding" EXACT []
is_a: GO:0043566 ! structure-specific DNA binding

[Term]
id: GO:0051881
name: regulation of mitochondrial membrane potential
namespace: biological_process
def: "Any process that modulates the establishment or extent of the mitochondrial membrane potential, the electric potential existing across the mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:ai]
is_a: GO:0042391 ! regulation of membrane potential

[Term]
id: GO:0051882
name: mitochondrial depolarization
namespace: biological_process
def: "The process in which the potential difference across the mitochondrial membrane is reduced from its steady state level." [Wikipedia:Depolarization, Wikipedia:Mitochondrion]
synonym: "mitochondria depolarization" EXACT []
synonym: "mitochondrial depolarisation" EXACT []
synonym: "mitochondrial membrane depolarization" EXACT []
synonym: "mitochondrion depolarization" EXACT []
is_a: GO:0051881 ! regulation of mitochondrial membrane potential
is_a: GO:0051899 ! membrane depolarization
intersection_of: GO:0051899 ! membrane depolarization
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion

[Term]
id: GO:0051883
name: killing of cells in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process mediated by an organism that results in the death of cells in a second organism, where the two organisms are in a symbiotic interaction." [GOC:add]
subset: gosubset_prok
synonym: "killing of cells in other organism during symbiotic interaction" RELATED [GOC:tb]
is_a: GO:0031640 ! killing of cells of other organism
is_a: GO:0051818 ! disruption of cells of other organism involved in symbiotic interaction

[Term]
id: GO:0051884
name: regulation of anagen
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of anagen, the growth phase of the hair cycle." [GOC:ai]
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:0048819 ! regulation of hair follicle maturation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042640 ! anagen
relationship: regulates GO:0042640 ! anagen

[Term]
id: GO:0051885
name: positive regulation of anagen
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of anagen, the growth phase of the hair cycle." [GOC:ai]
synonym: "activation of anagen" NARROW []
synonym: "stimulation of anagen" NARROW []
synonym: "up regulation of anagen" EXACT []
synonym: "up-regulation of anagen" EXACT []
synonym: "upregulation of anagen" EXACT []
is_a: GO:0048639 ! positive regulation of developmental growth
is_a: GO:0048818 ! positive regulation of hair follicle maturation
is_a: GO:0051884 ! regulation of anagen
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042640 ! anagen
relationship: positively_regulates GO:0042640 ! anagen

[Term]
id: GO:0051886
name: negative regulation of anagen
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of anagen, the growth phase of the hair cycle." [GOC:ai]
synonym: "down regulation of anagen" EXACT []
synonym: "down-regulation of anagen" EXACT []
synonym: "downregulation of anagen" EXACT []
synonym: "inhibition of anagen" NARROW []
is_a: GO:0048640 ! negative regulation of developmental growth
is_a: GO:0048817 ! negative regulation of hair follicle maturation
is_a: GO:0051884 ! regulation of anagen
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042640 ! anagen
relationship: negatively_regulates GO:0042640 ! anagen

[Term]
id: GO:0051887
name: regulation of exogen
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of exogen, the shedding phase of the hair cycle." [GOC:ai]
is_a: GO:0048819 ! regulation of hair follicle maturation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042638 ! exogen
relationship: regulates GO:0042638 ! exogen

[Term]
id: GO:0051888
name: positive regulation of exogen
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of exogen, the shedding phase of the hair cycle." [GOC:ai]
synonym: "activation of exogen" NARROW []
synonym: "stimulation of exogen" NARROW []
synonym: "up regulation of exogen" EXACT []
synonym: "up-regulation of exogen" EXACT []
synonym: "upregulation of exogen" EXACT []
is_a: GO:0048818 ! positive regulation of hair follicle maturation
is_a: GO:0051887 ! regulation of exogen
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042638 ! exogen
relationship: positively_regulates GO:0042638 ! exogen

[Term]
id: GO:0051889
name: negative regulation of exogen
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of exogen, the shedding phase of the hair cycle." [GOC:ai]
synonym: "down regulation of exogen" EXACT []
synonym: "down-regulation of exogen" EXACT []
synonym: "downregulation of exogen" EXACT []
synonym: "inhibition of exogen" NARROW []
is_a: GO:0048817 ! negative regulation of hair follicle maturation
is_a: GO:0051887 ! regulation of exogen
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042638 ! exogen
relationship: negatively_regulates GO:0042638 ! exogen

[Term]
id: GO:0051890
name: regulation of cardioblast differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:ai]
is_a: GO:2000026 ! regulation of multicellular organismal development
is_a: GO:2000736 ! regulation of stem cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010002 ! cardioblast differentiation
relationship: regulates GO:0010002 ! cardioblast differentiation

[Term]
id: GO:0051891
name: positive regulation of cardioblast differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:ai]
synonym: "activation of cardioblast differentiation" NARROW []
synonym: "stimulation of cardioblast differentiation" NARROW []
synonym: "up regulation of cardioblast differentiation" EXACT []
synonym: "up-regulation of cardioblast differentiation" EXACT []
synonym: "upregulation of cardioblast differentiation" EXACT []
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0051890 ! regulation of cardioblast differentiation
is_a: GO:2000738 ! positive regulation of stem cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010002 ! cardioblast differentiation
relationship: positively_regulates GO:0010002 ! cardioblast differentiation

[Term]
id: GO:0051892
name: negative regulation of cardioblast differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:ai]
synonym: "down regulation of cardioblast differentiation" EXACT []
synonym: "down-regulation of cardioblast differentiation" EXACT []
synonym: "downregulation of cardioblast differentiation" EXACT []
synonym: "inhibition of cardioblast differentiation" NARROW []
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0051890 ! regulation of cardioblast differentiation
is_a: GO:2000737 ! negative regulation of stem cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010002 ! cardioblast differentiation
relationship: negatively_regulates GO:0010002 ! cardioblast differentiation

[Term]
id: GO:0051893
name: regulation of focal adhesion assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of focal adhesion formation, the establishment and maturation of focal adhesions." [GOC:ai]
synonym: "regulation of adhesion plaque assembly" RELATED []
is_a: GO:0001952 ! regulation of cell-matrix adhesion
is_a: GO:0090109 ! regulation of cell-substrate junction assembly
is_a: GO:1903391 ! regulation of adherens junction organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048041 ! focal adhesion assembly
relationship: regulates GO:0048041 ! focal adhesion assembly

[Term]
id: GO:0051894
name: positive regulation of focal adhesion assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions." [GOC:ai]
synonym: "activation of focal adhesion formation" NARROW []
synonym: "stimulation of focal adhesion formation" NARROW []
synonym: "up regulation of focal adhesion formation" EXACT []
synonym: "up-regulation of focal adhesion formation" EXACT []
synonym: "upregulation of focal adhesion formation" EXACT []
is_a: GO:0001954 ! positive regulation of cell-matrix adhesion
is_a: GO:0051893 ! regulation of focal adhesion assembly
is_a: GO:1901890 ! positive regulation of cell junction assembly
is_a: GO:1903393 ! positive regulation of adherens junction organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048041 ! focal adhesion assembly
relationship: positively_regulates GO:0048041 ! focal adhesion assembly

[Term]
id: GO:0051895
name: negative regulation of focal adhesion assembly
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions." [GOC:ai]
synonym: "down regulation of focal adhesion formation" EXACT []
synonym: "down-regulation of focal adhesion formation" EXACT []
synonym: "downregulation of focal adhesion formation" EXACT []
synonym: "inhibition of focal adhesion formation" NARROW []
is_a: GO:0001953 ! negative regulation of cell-matrix adhesion
is_a: GO:0051893 ! regulation of focal adhesion assembly
is_a: GO:1901889 ! negative regulation of cell junction assembly
is_a: GO:1903392 ! negative regulation of adherens junction organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048041 ! focal adhesion assembly
relationship: negatively_regulates GO:0048041 ! focal adhesion assembly

[Term]
id: GO:0051896
name: regulation of protein kinase B signaling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B." [GOC:ai]
synonym: "regulation of AKT signaling cascade" RELATED []
synonym: "regulation of AKT signalling cascade" RELATED []
synonym: "regulation of PKB signaling cascade" RELATED []
synonym: "regulation of PKB signalling cascade" RELATED []
synonym: "regulation of protein kinase B signaling cascade" RELATED [GOC:signaling]
synonym: "regulation of protein kinase B signalling cascade" RELATED []
is_a: GO:1902531 ! regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043491 ! protein kinase B signaling
relationship: regulates GO:0043491 ! protein kinase B signaling

[Term]
id: GO:0051897
name: positive regulation of protein kinase B signaling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B." [GOC:ai]
synonym: "activation of protein kinase B signaling cascade" NARROW []
synonym: "positive regulation of AKT signaling cascade" RELATED []
synonym: "positive regulation of AKT signalling cascade" EXACT []
synonym: "positive regulation of PKB signaling cascade" EXACT []
synonym: "positive regulation of PKB signalling cascade" RELATED []
synonym: "positive regulation of protein kinase B signaling cascade" RELATED [GOC:signaling]
synonym: "positive regulation of protein kinase B signalling cascade" RELATED []
synonym: "stimulation of protein kinase B signaling cascade" NARROW []
synonym: "up regulation of protein kinase B signaling cascade" RELATED []
synonym: "up-regulation of protein kinase B signaling cascade" RELATED []
synonym: "upregulation of protein kinase B signaling cascade" RELATED []
is_a: GO:0051896 ! regulation of protein kinase B signaling
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043491 ! protein kinase B signaling
relationship: positively_regulates GO:0043491 ! protein kinase B signaling

[Term]
id: GO:0051898
name: negative regulation of protein kinase B signaling
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B." [GOC:ai]
synonym: "down regulation of protein kinase B signaling cascade" RELATED []
synonym: "down-regulation of protein kinase B signaling cascade" RELATED []
synonym: "downregulation of protein kinase B signaling cascade" RELATED []
synonym: "inhibition of protein kinase B signaling cascade" NARROW []
synonym: "negative regulation of AKT signaling cascade" RELATED []
synonym: "negative regulation of AKT signalling cascade" EXACT []
synonym: "negative regulation of PKB signaling cascade" EXACT []
synonym: "negative regulation of PKB signalling cascade" RELATED []
synonym: "negative regulation of protein kinase B signaling cascade" RELATED [GOC:signaling]
synonym: "negative regulation of protein kinase B signalling cascade" RELATED []
is_a: GO:0051896 ! regulation of protein kinase B signaling
is_a: GO:1902532 ! negative regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043491 ! protein kinase B signaling
relationship: negatively_regulates GO:0043491 ! protein kinase B signaling

[Term]
id: GO:0051899
name: membrane depolarization
namespace: biological_process
def: "The process in which membrane potential decreases with respect to its steady-state potential, usually from negative potential to a more positive potential. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative steady-state resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:dh, Wikipedia:Depolarization]
xref: Reactome:REACT_100841 "Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels, Rattus norvegicus"
xref: Reactome:REACT_109886 "Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels, Taeniopygia guttata"
xref: Reactome:REACT_114683 "Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels, Xenopus tropicalis"
xref: Reactome:REACT_13606 "Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels, Homo sapiens"
xref: Reactome:REACT_80752 "Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels, Sus scrofa"
xref: Reactome:REACT_83163 "Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels, Canis familiaris"
xref: Reactome:REACT_89275 "Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels, Mus musculus"
xref: Reactome:REACT_91353 "Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels, Danio rerio"
xref: Reactome:REACT_91520 "Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels, Bos taurus"
is_a: GO:0042391 ! regulation of membrane potential

[Term]
id: GO:0051900
name: regulation of mitochondrial depolarization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive." [GOC:ai]
is_a: GO:0003254 ! regulation of membrane depolarization
is_a: GO:0051881 ! regulation of mitochondrial membrane potential
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051882 ! mitochondrial depolarization
relationship: regulates GO:0051882 ! mitochondrial depolarization

[Term]
id: GO:0051901
name: positive regulation of mitochondrial depolarization
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive." [GOC:ai]
synonym: "activation of mitochondrial depolarization" NARROW []
synonym: "stimulation of mitochondrial depolarization" NARROW []
synonym: "up regulation of mitochondrial depolarization" EXACT []
synonym: "up-regulation of mitochondrial depolarization" EXACT []
synonym: "upregulation of mitochondrial depolarization" EXACT []
is_a: GO:0051900 ! regulation of mitochondrial depolarization
is_a: GO:1904181 ! positive regulation of membrane depolarization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051882 ! mitochondrial depolarization
relationship: positively_regulates GO:0051882 ! mitochondrial depolarization

[Term]
id: GO:0051902
name: negative regulation of mitochondrial depolarization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive." [GOC:ai]
synonym: "down regulation of mitochondrial depolarization" EXACT []
synonym: "down-regulation of mitochondrial depolarization" EXACT []
synonym: "downregulation of mitochondrial depolarization" EXACT []
synonym: "inhibition of mitochondrial depolarization" NARROW []
is_a: GO:0051900 ! regulation of mitochondrial depolarization
is_a: GO:1904180 ! negative regulation of membrane depolarization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051882 ! mitochondrial depolarization
relationship: negatively_regulates GO:0051882 ! mitochondrial depolarization

[Term]
id: GO:0051903
name: S-(hydroxymethyl)glutathione dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+." [EC:1.1.1.284]
synonym: "ADH3 activity" NARROW [EC:1.1.1.284]
synonym: "chi-ADH activity" NARROW [EC:1.1.1.284]
synonym: "class III alcohol dehydrogenase activity" RELATED [EC:1.1.1.284]
synonym: "FDH activity" RELATED [EC:1.1.1.284]
synonym: "formic dehydrogenase activity" RELATED [EC:1.1.1.284]
synonym: "GD-FALDH activity" EXACT [EC:1.1.1.284]
synonym: "glutathione-dependent formaldehyde dehydrogenase activity" EXACT [EC:1.1.1.284]
synonym: "GS-FDH activity" EXACT [EC:1.1.1.284]
synonym: "NAD- and glutathione-dependent formaldehyde dehydrogenase activity" EXACT [EC:1.1.1.284]
synonym: "NAD-dependent formaldehyde dehydrogenase activity" EXACT [EC:1.1.1.284]
synonym: "NAD-linked formaldehyde dehydrogenase activity" EXACT [EC:1.1.1.284]
synonym: "S-(hydroxymethyl)glutathione:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.284]
xref: EC:1.1.1.284
xref: KEGG:R06983
xref: KEGG:R07140
xref: MetaCyc:RXN-2962
xref: RHEA:19984
xref: RHEA:19988
xref: UM-BBD_reactionID:r1146
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0051904
name: pigment granule transport
namespace: biological_process
def: "The directed movement of pigment granules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "pigment granule translocation" EXACT []
is_a: GO:0044765 ! single-organism transport
is_a: GO:0051875 ! pigment granule localization
is_a: GO:0051905 ! establishment of pigment granule localization
is_a: GO:1902580 ! single-organism cellular localization

[Term]
id: GO:0051905
name: establishment of pigment granule localization
namespace: biological_process
def: "The directed movement of a pigment granule to a specific location." [GOC:ai]
synonym: "establishment of pigment granule localisation" EXACT [GOC:mah]
is_a: GO:0051650 ! establishment of vesicle localization
relationship: part_of GO:0051875 ! pigment granule localization

[Term]
id: GO:0051906
name: maintenance of pigment granule location
namespace: biological_process
def: "Any process in which a pigment granule is maintained in a location and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb]
synonym: "maintenance of pigment granule localization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051655 ! maintenance of vesicle location
relationship: part_of GO:0051875 ! pigment granule localization

[Term]
id: GO:0051907
name: S-(hydroxymethyl)glutathione synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-(hydroxymethyl)glutathione = formaldehyde + glutathione." [EC:4.4.1.22, RHEA:22491]
synonym: "Gfa" RELATED [EC:4.4.1.22]
synonym: "glutathione-dependent formaldehyde-activating enzyme activity" EXACT []
synonym: "S-(hydroxymethyl)glutathione formaldehyde-lyase (glutathione-forming)" EXACT [EC:4.4.1.22]
synonym: "S-(hydroxymethyl)glutathione formaldehyde-lyase activity" EXACT [EC:4.4.1.22]
xref: EC:4.4.1.22
xref: KEGG:R06982
xref: MetaCyc:RXN-2961
xref: RHEA:22491
xref: UM-BBD_reactionID:r1145
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0051908
name: double-stranded DNA 5'-3' exodeoxyribonuclease activity
namespace: molecular_function
def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a double-stranded DNA molecule." [GOC:ai]
synonym: "double-stranded DNA specific 5'-3' exodeoxyribonuclease activity" RELATED []
is_a: GO:0008309 ! double-stranded DNA exodeoxyribonuclease activity
is_a: GO:0035312 ! 5'-3' exodeoxyribonuclease activity

[Term]
id: GO:0051909
name: acetylenecarboxylate hydratase activity, producing 3-hydroxypropenoate
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxypropenoate = propynoate + H2O." [MetaCyc:ACETYLENECARBOXYLATE-HYDRATASE-RXN]
synonym: "3-hydroxypropenoate dehydratase activity" EXACT []
synonym: "acetylenecarboxylate hydratase activity" BROAD []
synonym: "acetylenemonocarboxylate hydratase activity" BROAD []
synonym: "alkynoate hydratase activity" BROAD []
xref: EC:4.2.1.-
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0051911
name: Methanosarcina-phenazine hydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2 + 2-(2,3-dihydropentaprenyloxy)phenazine = 2-dihydropentaprenyloxyphenazine." [EC:1.12.98.3]
synonym: "coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide hydrogenase activity" RELATED []
synonym: "hydrogen:2-(2,3-dihydropentaprenyloxy)phenazine oxidoreductase activity" EXACT [EC:1.12.98.3]
synonym: "methanophenazine hydrogenase activity" EXACT []
synonym: "methylviologen-reducing hydrogenase activity" EXACT []
xref: EC:1.12.98.3
xref: MetaCyc:RXN-7733
xref: RHEA:24439
is_a: GO:0046995 ! oxidoreductase activity, acting on hydrogen as donor, with other known acceptors

[Term]
id: GO:0051912
name: CoB--CoM heterodisulfide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: coenzyme B + coenzyme M + methanophenazine = N-{7-[(2-sulfoethyl)dithio]heptanoyl}-3-O-phospho-L-threonine + dihydromethanophenazine." [EC:1.8.98.1]
synonym: "CoB-CoM heterodisulfide reductase activity" EXACT []
synonym: "coenzyme B--coenzyme M heterodisulfide reductase activity" EXACT []
synonym: "coenzyme B:coenzyme M:methanophenazine oxidoreductase activity" EXACT [EC:1.8.98.1]
synonym: "coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide hydrogenase activity" RELATED []
synonym: "heterodisulfide reductase activity" BROAD []
synonym: "soluble heterodisulfide reductase activity" RELATED [EC:1.8.98.1]
xref: EC:1.8.98.1
xref: MetaCyc:1.8.98.1-RXN
xref: RHEA:18088
is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors

[Term]
id: GO:0051913
name: regulation of synaptic plasticity by chemical substance
namespace: biological_process
def: "The process in which a chemical substance modulates synaptic plasticity, the ability of synapses to change as circumstances require." [GOC:ai]
synonym: "regulation of synaptic plasticity by drug" NARROW []
is_a: GO:0048167 ! regulation of synaptic plasticity
relationship: part_of GO:0042221 ! response to chemical

[Term]
id: GO:0051914
name: positive regulation of synaptic plasticity by chemical substance
namespace: biological_process
def: "The process in which a chemical substance increases synaptic plasticity, the ability of synapses to change as circumstances require." [GOC:ai]
synonym: "activation of synaptic plasticity by chemical substance" NARROW []
synonym: "positive regulation of synaptic plasticity by drug" NARROW []
synonym: "stimulation of synaptic plasticity by chemical substance" NARROW []
synonym: "up regulation of synaptic plasticity by chemical substance" EXACT []
synonym: "up-regulation of synaptic plasticity by chemical substance" EXACT []
synonym: "upregulation of synaptic plasticity by chemical substance" EXACT []
is_a: GO:0031915 ! positive regulation of synaptic plasticity
is_a: GO:0051913 ! regulation of synaptic plasticity by chemical substance

[Term]
id: GO:0051915
name: induction of synaptic plasticity by chemical substance
namespace: biological_process
def: "The process in which a chemical substance activates synaptic plasticity, the ability of synapses to change as circumstances require." [GOC:ai]
synonym: "activation of synaptic plasticity by chemical substance" EXACT []
synonym: "activation of synaptic plasticity by drug" NARROW []
synonym: "induction of synaptic plasticity by drug" NARROW []
is_a: GO:0051914 ! positive regulation of synaptic plasticity by chemical substance

[Term]
id: GO:0051916
name: granulocyte colony-stimulating factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with granulocyte colony-stimulating factor, G-CSF." [GOC:ai]
synonym: "G-CSF binding" EXACT []
synonym: "granulocyte colony stimulating factor binding" EXACT []
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0051917
name: regulation of fibrinolysis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots." [GOC:ai]
is_a: GO:0030193 ! regulation of blood coagulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042730 ! fibrinolysis
relationship: regulates GO:0042730 ! fibrinolysis

[Term]
id: GO:0051918
name: negative regulation of fibrinolysis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots." [GOC:ai]
synonym: "down regulation of fibrinolysis" EXACT []
synonym: "down-regulation of fibrinolysis" EXACT []
synonym: "downregulation of fibrinolysis" EXACT []
synonym: "inhibition of fibrinolysis" NARROW []
is_a: GO:0030194 ! positive regulation of blood coagulation
is_a: GO:0032103 ! positive regulation of response to external stimulus
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0051917 ! regulation of fibrinolysis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042730 ! fibrinolysis
relationship: negatively_regulates GO:0042730 ! fibrinolysis

[Term]
id: GO:0051919
name: positive regulation of fibrinolysis
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots." [GOC:ai]
synonym: "activation of fibrinolysis" NARROW []
synonym: "stimulation of fibrinolysis" NARROW []
synonym: "up regulation of fibrinolysis" EXACT []
synonym: "up-regulation of fibrinolysis" EXACT []
synonym: "upregulation of fibrinolysis" EXACT []
is_a: GO:0030195 ! negative regulation of blood coagulation
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:0051917 ! regulation of fibrinolysis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042730 ! fibrinolysis
relationship: positively_regulates GO:0042730 ! fibrinolysis

[Term]
id: GO:0051920
name: peroxiredoxin activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH." [EC:1.11.1.15]
comment: Includes redox chemistry as part of the catalytic reaction (2 R'-SH = R'-S-S-R'), where R' refers to peroxiredoxin itself). Not to be confused with GO:0004601 (peroxidase activity, EC:1.11.1.7), which has a different reaction mechanism.
subset: gosubset_prok
synonym: "AhpC activity" NARROW []
synonym: "alkyl hydroperoxide reductase C22 activity" NARROW []
synonym: "PRDX activity" EXACT []
synonym: "Prx activity" EXACT []
synonym: "thiol-containing-reductant:hydroperoxide oxidoreductase activity" EXACT [EC:1.11.1.15]
xref: EC:1.11.1.15
xref: MetaCyc:1.11.1.15-RXN
is_a: GO:0016209 ! antioxidant activity
is_a: GO:0016684 ! oxidoreductase activity, acting on peroxide as acceptor

[Term]
id: GO:0051921
name: adenosylcobyric acid synthase (glutamine-hydrolyzing) activity
namespace: molecular_function
def: "Catalysis of the reaction: 4 L-glutamine + adenosylcob(III)yrinate a,c-diamide + 4 ATP + 4 H(2)O = 4 L-glutamate + adenosylcobyrate + 4 ADP + 8 H(+) + 4 phosphate." [EC:6.3.5.10, RHEA:23259]
synonym: "5'-deoxy-5'-adenosylcobyrinic-acid-a,c-diamide:L-glutamine amido-ligase activity" EXACT []
synonym: "adenosylcobyric acid synthase (glutamine-hydrolysing) activity" EXACT []
synonym: "adenosylcobyrinic-acid-a,c-diamide:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.10]
synonym: "Ado-cobyric acid synthase [glutamine hydrolyzing] activity" EXACT []
synonym: "CobQ activity" BROAD []
synonym: "cobyric acid synthase activity" RELATED []
xref: EC:6.3.5.10
xref: KEGG:R05225
xref: MetaCyc:R345-RXN
xref: RHEA:23259
is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor

[Term]
id: GO:0051922
name: cholesterol sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + cholesterol = adenosine 3',5'-bisphosphate + cholesterol sulfate." [PMID:12730293]
xref: EC:2.8.2.-
is_a: GO:0004027 ! alcohol sulfotransferase activity

[Term]
id: GO:0051923
name: sulfation
namespace: biological_process
def: "The addition of a sulfate group to a molecule." [http://www.onelook.com]
subset: gosubset_prok
synonym: "phase II metabolism" BROAD [PMID:20056724]
synonym: "sulfonation" EXACT []
synonym: "sulfur addition" EXACT []
synonym: "sulphation" EXACT []
synonym: "sulphur addition" EXACT []
is_a: GO:0006790 ! sulfur compound metabolic process

[Term]
id: GO:0051924
name: regulation of calcium ion transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "regulation of calcium transport" EXACT []
is_a: GO:0010959 ! regulation of metal ion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006816 ! calcium ion transport
relationship: regulates GO:0006816 ! calcium ion transport

[Term]
id: GO:0051925
name: obsolete regulation of calcium ion transport via voltage-gated calcium channel activity
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the directed movement of calcium ions via a voltage-gated calcium channel." [GOC:ai]
comment: This term was made obsolete because it is ill-defined: channel activities are part of ion transport processes, and not the other way round.
synonym: "regulation of calcium ion transport via voltage-gated calcium channel activity" EXACT []
synonym: "regulation of calcium transport via voltage-gated calcium channel" EXACT []
is_obsolete: true
consider: GO:0005245

[Term]
id: GO:0051926
name: negative regulation of calcium ion transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "down regulation of calcium ion transport" EXACT []
synonym: "down-regulation of calcium ion transport" EXACT []
synonym: "downregulation of calcium ion transport" EXACT []
synonym: "inhibition of calcium ion transport" NARROW []
synonym: "negative regulation of calcium transport" EXACT []
is_a: GO:0043271 ! negative regulation of ion transport
is_a: GO:0051924 ! regulation of calcium ion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006816 ! calcium ion transport
relationship: negatively_regulates GO:0006816 ! calcium ion transport

[Term]
id: GO:0051927
name: obsolete negative regulation of calcium ion transport via voltage-gated calcium channel activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of calcium ions via a voltage-gated calcium channel." [GOC:ai]
comment: This term was made obsolete because it is ill-defined: channel activities are part of ion transport processes, and not the other way round.
synonym: "down regulation of calcium ion transport via voltage gated calcium channel" EXACT []
synonym: "down-regulation of calcium ion transport via voltage gated calcium channel" EXACT []
synonym: "downregulation of calcium ion transport via voltage gated calcium channel" EXACT []
synonym: "inhibition of calcium ion transport via voltage gated calcium channel" NARROW []
synonym: "negative regulation of calcium ion transport via voltage-gated calcium channel activity" EXACT []
synonym: "negative regulation of calcium transport via voltage gated calcium channel" RELATED []
is_obsolete: true
consider: GO:0005245

[Term]
id: GO:0051928
name: positive regulation of calcium ion transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "activation of calcium ion transport" NARROW []
synonym: "positive regulation of calcium transport" EXACT []
synonym: "stimulation of calcium ion transport" NARROW []
synonym: "up regulation of calcium ion transport" EXACT []
synonym: "up-regulation of calcium ion transport" EXACT []
synonym: "upregulation of calcium ion transport" EXACT []
is_a: GO:0043270 ! positive regulation of ion transport
is_a: GO:0051924 ! regulation of calcium ion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006816 ! calcium ion transport
relationship: positively_regulates GO:0006816 ! calcium ion transport

[Term]
id: GO:0051929
name: obsolete positive regulation of calcium ion transport via voltage-gated calcium channel activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions via the activity of voltage-gated calcium channels." [GOC:ai]
comment: This term was made obsolete because it is ill-defined: channel activities are part of ion transport processes, and not the other way round.
synonym: "activation of calcium ion transport via voltage gated calcium channel" NARROW []
synonym: "positive regulation of calcium ion transport via voltage-gated calcium channel activity" EXACT []
synonym: "positive regulation of calcium transport via voltage gated calcium channel" EXACT []
synonym: "stimulation of calcium ion transport via voltage gated calcium channel" NARROW []
synonym: "up regulation of calcium ion transport via voltage gated calcium channel" EXACT []
synonym: "up-regulation of calcium ion transport via voltage gated calcium channel" EXACT []
synonym: "upregulation of calcium ion transport via voltage gated calcium channel" EXACT []
is_obsolete: true
consider: GO:0005245

[Term]
id: GO:0051930
name: regulation of sensory perception of pain
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal." [GOC:ai]
is_a: GO:0051931 ! regulation of sensory perception
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019233 ! sensory perception of pain
relationship: regulates GO:0019233 ! sensory perception of pain

[Term]
id: GO:0051931
name: regulation of sensory perception
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sensory perception, the series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal." [GOC:ai]
is_a: GO:0031644 ! regulation of neurological system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007600 ! sensory perception
relationship: regulates GO:0007600 ! sensory perception

[Term]
id: GO:0051932
name: synaptic transmission, GABAergic
namespace: biological_process
def: "The process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA)." [ISBN:0126603030]
synonym: "synaptic transmission, GABA mediated" EXACT []
synonym: "synaptic transmission, gamma-aminobutyric acid mediated" EXACT []
synonym: "synaptic transmission, gamma-aminobutyric acid-ergic" EXACT []
is_a: GO:0007270 ! neuron-neuron synaptic transmission

[Term]
id: GO:0051933
name: amino acid neurotransmitter reuptake
namespace: biological_process
def: "The uptake of amino acid neurotransmitters by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters." [ISBN:0123668387]
synonym: "amino acid neurotransmitter import into glial cell" NARROW []
synonym: "amino acid neurotransmitter import into neuron" NARROW []
synonym: "amino acid neurotransmitter recycling" BROAD []
synonym: "amino acid uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb]
is_a: GO:0098810 ! neurotransmitter reuptake
is_a: GO:1902837 ! amino acid import into cell

[Term]
id: GO:0051934
name: catecholamine uptake involved in synaptic transmission
namespace: biological_process
def: "The uptake of catecholamine neurotransmitters by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters." [ISBN:0123668387]
synonym: "catecholamine neurotransmitter import into glial cell" NARROW []
synonym: "catecholamine neurotransmitter import into neuron" NARROW []
synonym: "catecholamine neurotransmitter recycling" BROAD []
synonym: "catecholamine neurotransmitter reuptake" EXACT []
synonym: "catecholamine reuptake during transmission of nerve impulse" RELATED []
synonym: "catecholamine uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb]
is_a: GO:0090493 ! catecholamine uptake
is_a: GO:0098810 ! neurotransmitter reuptake

[Term]
id: GO:0051935
name: glutamate reuptake
namespace: biological_process
def: "The uptake of L-glutamate by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters." [ISBN:0123668387]
synonym: "glutamate import into glial cell" NARROW []
synonym: "glutamate import into neuron" NARROW []
synonym: "glutamate recycling" BROAD []
synonym: "glutamate reuptake" EXACT []
synonym: "glutamate uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb]
synonym: "L-glutamate reuptake" EXACT []
synonym: "L-glutamate uptake during transmission of nerve impulse" RELATED []
synonym: "L-glutamate uptake involved in synaptic transmission" EXACT []
is_a: GO:0051933 ! amino acid neurotransmitter reuptake
is_a: GO:1990123 ! L-glutamate import into cell

[Term]
id: GO:0051936
name: gamma-aminobutyric acid reuptake
namespace: biological_process
def: "The uptake of gamma-aminobutyric acid (GABA, 4-aminobutyrate) by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters." [ISBN:0123668387]
synonym: "GABA import into glial cell" NARROW []
synonym: "GABA import into neuron" NARROW []
synonym: "GABA recycling" BROAD []
synonym: "GABA reuptake" EXACT []
synonym: "gamma-aminobutyric acid import into glial cell" NARROW []
synonym: "gamma-aminobutyric acid import into neuron" NARROW []
synonym: "gamma-aminobutyric acid recycling" BROAD []
synonym: "gamma-aminobutyric acid uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb]
synonym: "gamma-aminobutyric acid uptake involved in synaptic transmission" EXACT []
is_a: GO:0051933 ! amino acid neurotransmitter reuptake
is_a: GO:0051939 ! gamma-aminobutyric acid import

[Term]
id: GO:0051937
name: catecholamine transport
namespace: biological_process
def: "The directed movement of catecholamines, a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:ai, ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0015844 ! monoamine transport
is_a: GO:0015850 ! organic hydroxy compound transport

[Term]
id: GO:0051938
name: L-glutamate import
namespace: biological_process
def: "The directed movement of L-glutamate, the L-enantiomer of the anion of 2-aminopentanedioic acid, into a cell or organelle." [GOC:ai, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "L-glutamate uptake" EXACT [GOC:dph, GOC:tb]
is_a: GO:0015813 ! L-glutamate transport
is_a: GO:0043092 ! L-amino acid import

[Term]
id: GO:0051939
name: gamma-aminobutyric acid import
namespace: biological_process
def: "The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a cell or organelle." [GOC:ai]
subset: gosubset_prok
synonym: "4-aminobutyrate import" EXACT []
synonym: "GABA import" EXACT []
synonym: "gamma-aminobutyrate import" EXACT []
synonym: "gamma-aminobutyric acid uptake" EXACT [GOC:dph, GOC:tb]
is_a: GO:0015800 ! acidic amino acid transport
is_a: GO:0015812 ! gamma-aminobutyric acid transport
is_a: GO:0043090 ! amino acid import

[Term]
id: GO:0051940
name: regulation of catecholamine uptake involved in synaptic transmission
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of catecholamine neurotransmitters into a neuron or glial cell." [GOC:ai]
synonym: "regulation of catecholamine neurotransmitter reuptake" EXACT []
synonym: "regulation of catecholamine neurotransmitter uptake" EXACT []
synonym: "regulation of catecholamine uptake during transmission of nerve impulse" BROAD [GOC:dph, GOC:tb]
is_a: GO:0051580 ! regulation of neurotransmitter uptake
is_a: GO:0051952 ! regulation of amine transport
is_a: GO:0060341 ! regulation of cellular localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051934 ! catecholamine uptake involved in synaptic transmission
relationship: regulates GO:0051934 ! catecholamine uptake involved in synaptic transmission

[Term]
id: GO:0051941
name: regulation of amino acid uptake involved in synaptic transmission
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of amino acid neurotransmitters into a neuron or glial cell." [GOC:ai]
synonym: "regulation of amino acid neurotransmitter reuptake" EXACT []
synonym: "regulation of amino acid neurotransmitter uptake" EXACT []
synonym: "regulation of amino acid uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb]
is_a: GO:0010958 ! regulation of amino acid import
is_a: GO:0051580 ! regulation of neurotransmitter uptake
is_a: GO:0060341 ! regulation of cellular localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051933 ! amino acid neurotransmitter reuptake
relationship: regulates GO:0051933 ! amino acid neurotransmitter reuptake

[Term]
id: GO:0051942
name: negative regulation of amino acid uptake involved in synaptic transmission
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amino acid neurotransmitters into a neuron or glial cell." [GOC:ai]
synonym: "down regulation of amino acid uptake during transmission of nerve impulse" RELATED []
synonym: "down-regulation of amino acid uptake during transmission of nerve impulse" RELATED []
synonym: "downregulation of amino acid uptake during transmission of nerve impulse" RELATED []
synonym: "inhibition of amino acid uptake during transmission of nerve impulse" RELATED []
synonym: "negative regulation of amino acid neurotransmitter reuptake" EXACT []
synonym: "negative regulation of amino acid neurotransmitter uptake" EXACT []
synonym: "negative regulation of amino acid uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051581 ! negative regulation of neurotransmitter uptake
is_a: GO:0051941 ! regulation of amino acid uptake involved in synaptic transmission
is_a: GO:0051956 ! negative regulation of amino acid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051933 ! amino acid neurotransmitter reuptake
relationship: negatively_regulates GO:0051933 ! amino acid neurotransmitter reuptake

[Term]
id: GO:0051943
name: positive regulation of amino acid uptake involved in synaptic transmission
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amino acid neurotransmitters into a neuron or glial cell." [GOC:ai]
synonym: "activation of amino acid uptake during transmission of nerve impulse" RELATED []
synonym: "positive regulation of amino acid neurotransmitter reuptake" EXACT []
synonym: "positive regulation of amino acid neurotransmitter uptake" EXACT []
synonym: "stimulation of amino acid uptake during transmission of nerve impulse" NARROW []
synonym: "up regulation of amino acid uptake during transmission of nerve impulse" RELATED []
synonym: "up-regulation of amino acid uptake during transmission of nerve impulse" RELATED []
synonym: "upregulation of amino acid uptake during transmission of nerve impulse" RELATED []
is_a: GO:0051582 ! positive regulation of neurotransmitter uptake
is_a: GO:0051941 ! regulation of amino acid uptake involved in synaptic transmission
is_a: GO:0051957 ! positive regulation of amino acid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051933 ! amino acid neurotransmitter reuptake
relationship: positively_regulates GO:0051933 ! amino acid neurotransmitter reuptake

[Term]
id: GO:0051944
name: positive regulation of catecholamine uptake involved in synaptic transmission
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of catecholamine neurotransmitters into a neuron or glial cell." [GOC:ai, GOC:dph, GOC:tb]
synonym: "activation of catecholamine uptake during transmission of nerve impulse" NARROW []
synonym: "positive regulation of catecholamine neurotransmitter reuptake" EXACT []
synonym: "positive regulation of catecholamine neurotransmitter uptake" EXACT []
synonym: "positive regulation of catecholamine uptake during transmission of nerve impulse" BROAD [GOC:dph, GOC:tb]
synonym: "stimulation of catecholamine uptake during transmission of nerve impulse" NARROW []
synonym: "up regulation of catecholamine uptake during transmission of nerve impulse" EXACT []
synonym: "up-regulation of catecholamine uptake during transmission of nerve impulse" EXACT []
synonym: "upregulation of catecholamine uptake during transmission of nerve impulse" EXACT []
is_a: GO:0051582 ! positive regulation of neurotransmitter uptake
is_a: GO:0051940 ! regulation of catecholamine uptake involved in synaptic transmission
is_a: GO:0051954 ! positive regulation of amine transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051934 ! catecholamine uptake involved in synaptic transmission
relationship: positively_regulates GO:0051934 ! catecholamine uptake involved in synaptic transmission

[Term]
id: GO:0051945
name: negative regulation of catecholamine uptake involved in synaptic transmission
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of catecholamine neurotransmitters into a neuron or glial cell." [GOC:ai, GOC:dph, GOC:tb]
synonym: "down regulation of catecholamine uptake during transmission of nerve impulse" EXACT []
synonym: "down-regulation of catecholamine uptake during transmission of nerve impulse" EXACT []
synonym: "downregulation of catecholamine uptake during transmission of nerve impulse" EXACT []
synonym: "inhibition of catecholamine uptake during transmission of nerve impulse" NARROW []
synonym: "negative regulation of catecholamine neurotransmitter reuptake" EXACT []
synonym: "negative regulation of catecholamine neurotransmitter uptake" EXACT []
synonym: "negative regulation of catecholamine uptake during transmission of nerve impulse" BROAD [GOC:dph, GOC:tb]
is_a: GO:0051581 ! negative regulation of neurotransmitter uptake
is_a: GO:0051940 ! regulation of catecholamine uptake involved in synaptic transmission
is_a: GO:0051953 ! negative regulation of amine transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051934 ! catecholamine uptake involved in synaptic transmission
relationship: negatively_regulates GO:0051934 ! catecholamine uptake involved in synaptic transmission

[Term]
id: GO:0051946
name: regulation of glutamate uptake involved in transmission of nerve impulse
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of L-glutamate into a neuron or glial cell." [GOC:ai]
synonym: "regulation of glutamate reuptake" EXACT []
synonym: "regulation of glutamate uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb]
synonym: "regulation of glutamate uptake involved in conduction of nerve impulse" EXACT [GOC:dph]
synonym: "regulation of L-glutamate reuptake" EXACT []
synonym: "regulation of L-glutamate uptake during transmission of nerve impulse" EXACT []
is_a: GO:0051941 ! regulation of amino acid uptake involved in synaptic transmission
is_a: GO:1900920 ! regulation of L-glutamate import
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051935 ! glutamate reuptake
relationship: regulates GO:0051935 ! glutamate reuptake

[Term]
id: GO:0051947
name: regulation of gamma-aminobutyric acid uptake involved in transmission of nerve impulse
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a neuron or glial cell." [GOC:ai]
synonym: "regulation of 4-aminobutyrate reuptake" EXACT []
synonym: "regulation of 4-aminobutyrate uptake during transmission of nerve impulse" EXACT []
synonym: "regulation of GABA reuptake" EXACT []
synonym: "regulation of GABA uptake during transmission of nerve impulse" EXACT []
synonym: "regulation of gamma-aminobutyric acid reuptake" EXACT []
synonym: "regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb]
synonym: "regulation of gamma-aminobutyric acid uptake involved in conduction of nerve impulse" EXACT [GOC:dph]
is_a: GO:0051941 ! regulation of amino acid uptake involved in synaptic transmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051936 ! gamma-aminobutyric acid reuptake
relationship: regulates GO:0051936 ! gamma-aminobutyric acid reuptake

[Term]
id: GO:0051948
name: negative regulation of glutamate uptake involved in transmission of nerve impulse
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of L-glutamate into a neuron or glial cell." [GOC:ai]
synonym: "down regulation of glutamate uptake during transmission of nerve impulse" EXACT []
synonym: "down-regulation of glutamate uptake during transmission of nerve impulse" EXACT []
synonym: "downregulation of glutamate uptake during transmission of nerve impulse" EXACT []
synonym: "inhibition of glutamate uptake during transmission of nerve impulse" NARROW []
synonym: "negative regulation of glutamate reuptake" EXACT []
synonym: "negative regulation of glutamate uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb]
synonym: "negative regulation of glutamate uptake involved in conduction of nerve impulse" RELATED [GOC:dph]
is_a: GO:0051942 ! negative regulation of amino acid uptake involved in synaptic transmission
is_a: GO:0051946 ! regulation of glutamate uptake involved in transmission of nerve impulse
is_a: GO:1900921 ! negative regulation of L-glutamate import
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051935 ! glutamate reuptake
relationship: negatively_regulates GO:0051935 ! glutamate reuptake

[Term]
id: GO:0051949
name: negative regulation of gamma-aminobutyric acid uptake involved in transmission of nerve impulse
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a neuron or glial cell." [GOC:ai]
synonym: "down regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" EXACT []
synonym: "down-regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" EXACT []
synonym: "downregulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" EXACT []
synonym: "inhibition of gamma-aminobutyric acid uptake during transmission of nerve impulse" NARROW []
synonym: "negative regulation of 4-aminobutyrate reuptake" EXACT []
synonym: "negative regulation of 4-aminobutyrate uptake during transmission of nerve impulse" EXACT []
synonym: "negative regulation of GABA reuptake" EXACT []
synonym: "negative regulation of GABA uptake during transmission of nerve impulse" EXACT []
synonym: "negative regulation of gamma-aminobutyric acid reuptake" EXACT []
synonym: "negative regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb]
synonym: "negative regulation of gamma-aminobutyric acid uptake involved in conduction of nerve impulse" EXACT [GOC:dph]
is_a: GO:0051942 ! negative regulation of amino acid uptake involved in synaptic transmission
is_a: GO:0051947 ! regulation of gamma-aminobutyric acid uptake involved in transmission of nerve impulse
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051936 ! gamma-aminobutyric acid reuptake
relationship: negatively_regulates GO:0051936 ! gamma-aminobutyric acid reuptake

[Term]
id: GO:0051950
name: positive regulation of gamma-aminobutyric acid uptake involved in transmission of nerve impulse
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a neuron or glial cell." [GOC:ai]
synonym: "activation of gamma-aminobutyric acid uptake during transmission of nerve impulse" NARROW []
synonym: "positive regulation of 4-aminobutyrate reuptake" EXACT []
synonym: "positive regulation of 4-aminobutyrate uptake during transmission of nerve impulse" EXACT []
synonym: "positive regulation of GABA reuptake" EXACT []
synonym: "positive regulation of GABA uptake during transmission of nerve impulse" EXACT []
synonym: "positive regulation of gamma-aminobutyric acid reuptake" EXACT []
synonym: "positive regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb]
synonym: "positive regulation of gamma-aminobutyric acid uptake involved in conduction of nerve impulse" EXACT [GOC:dph]
synonym: "stimulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" NARROW []
synonym: "up regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" EXACT []
synonym: "up-regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" EXACT []
synonym: "upregulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" EXACT []
is_a: GO:0051943 ! positive regulation of amino acid uptake involved in synaptic transmission
is_a: GO:0051947 ! regulation of gamma-aminobutyric acid uptake involved in transmission of nerve impulse
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051936 ! gamma-aminobutyric acid reuptake
relationship: positively_regulates GO:0051936 ! gamma-aminobutyric acid reuptake

[Term]
id: GO:0051951
name: positive regulation of glutamate uptake involved in transmission of nerve impulse
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of L-glutamate into a neuron or glial cell." [GOC:ai]
synonym: "activation of glutamate uptake during transmission of nerve impulse" NARROW []
synonym: "positive regulation of glutamate reuptake" EXACT []
synonym: "positive regulation of glutamate uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb]
synonym: "positive regulation of glutamate uptake involved in conduction of nerve impulse" EXACT [GOC:dph]
synonym: "stimulation of glutamate uptake during transmission of nerve impulse" NARROW []
synonym: "up regulation of glutamate uptake during transmission of nerve impulse" EXACT []
synonym: "up-regulation of glutamate uptake during transmission of nerve impulse" EXACT []
synonym: "upregulation of glutamate uptake during transmission of nerve impulse" EXACT []
is_a: GO:0051943 ! positive regulation of amino acid uptake involved in synaptic transmission
is_a: GO:0051946 ! regulation of glutamate uptake involved in transmission of nerve impulse
is_a: GO:1900922 ! positive regulation of L-glutamate import
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051935 ! glutamate reuptake
relationship: positively_regulates GO:0051935 ! glutamate reuptake

[Term]
id: GO:0051952
name: regulation of amine transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0015837 ! amine transport
relationship: regulates GO:0015837 ! amine transport

[Term]
id: GO:0051953
name: negative regulation of amine transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "down regulation of amine transport" EXACT []
synonym: "down-regulation of amine transport" EXACT []
synonym: "downregulation of amine transport" EXACT []
synonym: "inhibition of amine transport" NARROW []
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:0051952 ! regulation of amine transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0015837 ! amine transport
relationship: negatively_regulates GO:0015837 ! amine transport

[Term]
id: GO:0051954
name: positive regulation of amine transport
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "activation of amine transport" NARROW []
synonym: "stimulation of amine transport" NARROW []
synonym: "up regulation of amine transport" EXACT []
synonym: "up-regulation of amine transport" EXACT []
synonym: "upregulation of amine transport" EXACT []
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:0051952 ! regulation of amine transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0015837 ! amine transport
relationship: positively_regulates GO:0015837 ! amine transport

[Term]
id: GO:0051955
name: regulation of amino acid transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0032890 ! regulation of organic acid transport
is_a: GO:0044070 ! regulation of anion transport
is_a: GO:0051952 ! regulation of amine transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006865 ! amino acid transport
relationship: regulates GO:0006865 ! amino acid transport

[Term]
id: GO:0051956
name: negative regulation of amino acid transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "down regulation of amino acid transport" EXACT []
synonym: "down-regulation of amino acid transport" EXACT []
synonym: "downregulation of amino acid transport" EXACT []
synonym: "inhibition of amino acid transport" NARROW []
synonym: "negative regulation of amino acid transmembrane transport" EXACT [GOC:mah]
is_a: GO:0032891 ! negative regulation of organic acid transport
is_a: GO:0051953 ! negative regulation of amine transport
is_a: GO:0051955 ! regulation of amino acid transport
is_a: GO:1903792 ! negative regulation of anion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006865 ! amino acid transport
relationship: negatively_regulates GO:0006865 ! amino acid transport

[Term]
id: GO:0051957
name: positive regulation of amino acid transport
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "activation of amino acid transport" NARROW []
synonym: "positive regulation of amino acid transmembrane transport" EXACT [GOC:mah]
synonym: "stimulation of amino acid transport" NARROW []
synonym: "up regulation of amino acid transport" EXACT []
synonym: "up-regulation of amino acid transport" EXACT []
synonym: "upregulation of amino acid transport" EXACT []
is_a: GO:0032892 ! positive regulation of organic acid transport
is_a: GO:0051954 ! positive regulation of amine transport
is_a: GO:0051955 ! regulation of amino acid transport
is_a: GO:1903793 ! positive regulation of anion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006865 ! amino acid transport
relationship: positively_regulates GO:0006865 ! amino acid transport

[Term]
id: GO:0051958
name: methotrexate transport
namespace: biological_process
def: "The directed movement of methotrexate, 4-amino-10-methylformic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase." [GOC:ai]
is_a: GO:0006835 ! dicarboxylic acid transport
is_a: GO:0015893 ! drug transport
is_a: GO:0042886 ! amide transport

[Term]
id: GO:0051959
name: dynein light intermediate chain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a light intermediate chain of the dynein complex." [GOC:bf]
is_a: GO:0045502 ! dynein binding

[Term]
id: GO:0051960
name: regulation of nervous system development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai]
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007399 ! nervous system development
relationship: regulates GO:0007399 ! nervous system development

[Term]
id: GO:0051961
name: negative regulation of nervous system development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai]
synonym: "down regulation of nervous system development" EXACT []
synonym: "down-regulation of nervous system development" EXACT []
synonym: "downregulation of nervous system development" EXACT []
synonym: "inhibition of nervous system development" NARROW []
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0051960 ! regulation of nervous system development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007399 ! nervous system development
relationship: negatively_regulates GO:0007399 ! nervous system development

[Term]
id: GO:0051962
name: positive regulation of nervous system development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai]
synonym: "activation of nervous system development" NARROW []
synonym: "stimulation of nervous system development" NARROW []
synonym: "up regulation of nervous system development" EXACT []
synonym: "up-regulation of nervous system development" EXACT []
synonym: "upregulation of nervous system development" EXACT []
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0051960 ! regulation of nervous system development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007399 ! nervous system development
relationship: positively_regulates GO:0007399 ! nervous system development

[Term]
id: GO:0051963
name: regulation of synapse assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:ai, GOC:pr]
subset: goslim_synapse
synonym: "regulation of synapse biogenesis" EXACT []
synonym: "regulation of synaptogenesis" EXACT []
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0050807 ! regulation of synapse organization
is_a: GO:0051960 ! regulation of nervous system development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007416 ! synapse assembly
relationship: regulates GO:0007416 ! synapse assembly

[Term]
id: GO:0051964
name: negative regulation of synapse assembly
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:ai, GOC:pr]
synonym: "down regulation of synapse assembly" EXACT []
synonym: "down-regulation of synapse assembly" EXACT []
synonym: "downregulation of synapse assembly" EXACT []
synonym: "inhibition of synapse assembly" NARROW []
synonym: "negative regulation of synapse biogenesis" EXACT []
synonym: "negative regulation of synaptogenesis" EXACT []
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:0051961 ! negative regulation of nervous system development
is_a: GO:0051963 ! regulation of synapse assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007416 ! synapse assembly
relationship: negatively_regulates GO:0007416 ! synapse assembly

[Term]
id: GO:0051965
name: positive regulation of synapse assembly
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:ai, GOC:pr]
synonym: "activation of synapse assembly" NARROW []
synonym: "positive regulation of synapse biogenesis" EXACT []
synonym: "positive regulation of synaptogenesis" EXACT []
synonym: "stimulation of synapse assembly" NARROW []
synonym: "up regulation of synapse assembly" EXACT []
synonym: "up-regulation of synapse assembly" EXACT []
synonym: "upregulation of synapse assembly" EXACT []
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:0051962 ! positive regulation of nervous system development
is_a: GO:0051963 ! regulation of synapse assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007416 ! synapse assembly
relationship: positively_regulates GO:0007416 ! synapse assembly

[Term]
id: GO:0051966
name: regulation of synaptic transmission, glutamatergic
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]
is_a: GO:0050804 ! modulation of synaptic transmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035249 ! synaptic transmission, glutamatergic
relationship: regulates GO:0035249 ! synaptic transmission, glutamatergic

[Term]
id: GO:0051967
name: negative regulation of synaptic transmission, glutamatergic
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]
synonym: "down regulation of synaptic transmission, glutamatergic" EXACT []
synonym: "down-regulation of synaptic transmission, glutamatergic" EXACT []
synonym: "downregulation of synaptic transmission, glutamatergic" EXACT []
synonym: "inhibition of synaptic transmission, glutamatergic" NARROW []
is_a: GO:0050805 ! negative regulation of synaptic transmission
is_a: GO:0051966 ! regulation of synaptic transmission, glutamatergic
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035249 ! synaptic transmission, glutamatergic
relationship: negatively_regulates GO:0035249 ! synaptic transmission, glutamatergic

[Term]
id: GO:0051968
name: positive regulation of synaptic transmission, glutamatergic
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]
synonym: "activation of synaptic transmission, glutamatergic" NARROW []
synonym: "stimulation of synaptic transmission, glutamatergic" NARROW []
synonym: "up regulation of synaptic transmission, glutamatergic" EXACT []
synonym: "up-regulation of synaptic transmission, glutamatergic" EXACT []
synonym: "upregulation of synaptic transmission, glutamatergic" EXACT []
is_a: GO:0050806 ! positive regulation of synaptic transmission
is_a: GO:0051966 ! regulation of synaptic transmission, glutamatergic
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035249 ! synaptic transmission, glutamatergic
relationship: positively_regulates GO:0035249 ! synaptic transmission, glutamatergic

[Term]
id: GO:0051969
name: regulation of transmission of nerve impulse
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation." [GOC:ai]
synonym: "regulation of conduction of nerve impulse" EXACT [GOC:dph]
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0023051 ! regulation of signaling
is_a: GO:0031644 ! regulation of neurological system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019226 ! transmission of nerve impulse
relationship: regulates GO:0019226 ! transmission of nerve impulse

[Term]
id: GO:0051970
name: negative regulation of transmission of nerve impulse
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation." [GOC:ai]
synonym: "down regulation of transmission of nerve impulse" EXACT []
synonym: "down-regulation of transmission of nerve impulse" EXACT []
synonym: "downregulation of transmission of nerve impulse" EXACT []
synonym: "inhibition of transmission of nerve impulse" NARROW []
synonym: "negative regulation of conduction of nerve impulse" EXACT [GOC:dph]
is_a: GO:0010648 ! negative regulation of cell communication
is_a: GO:0023057 ! negative regulation of signaling
is_a: GO:0031645 ! negative regulation of neurological system process
is_a: GO:0051969 ! regulation of transmission of nerve impulse
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019226 ! transmission of nerve impulse
relationship: negatively_regulates GO:0019226 ! transmission of nerve impulse

[Term]
id: GO:0051971
name: positive regulation of transmission of nerve impulse
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation." [GOC:ai]
synonym: "activation of transmission of nerve impulse" NARROW []
synonym: "positive regulation of conduction of nerve impulse" EXACT [GOC:dph]
synonym: "stimulation of transmission of nerve impulse" NARROW []
synonym: "up regulation of transmission of nerve impulse" EXACT []
synonym: "up-regulation of transmission of nerve impulse" EXACT []
synonym: "upregulation of transmission of nerve impulse" EXACT []
is_a: GO:0010647 ! positive regulation of cell communication
is_a: GO:0023056 ! positive regulation of signaling
is_a: GO:0031646 ! positive regulation of neurological system process
is_a: GO:0051969 ! regulation of transmission of nerve impulse
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0019226 ! transmission of nerve impulse
relationship: positively_regulates GO:0019226 ! transmission of nerve impulse

[Term]
id: GO:0051972
name: regulation of telomerase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Telomerases catalyze extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence." [EC:2.-.-.-, GOC:ai]
synonym: "telomerase regulator" EXACT []
is_a: GO:0006275 ! regulation of DNA replication
is_a: GO:0051338 ! regulation of transferase activity
is_a: GO:2000278 ! regulation of DNA biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003720 ! telomerase activity
relationship: regulates GO:0003720 ! telomerase activity

[Term]
id: GO:0051973
name: positive regulation of telomerase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)." [GOC:ai]
synonym: "activation of telomerase activity" NARROW []
synonym: "stimulation of telomerase activity" NARROW []
synonym: "telomerase activator" RELATED []
synonym: "up regulation of telomerase activity" EXACT []
synonym: "up-regulation of telomerase activity" EXACT []
synonym: "upregulation of telomerase activity" EXACT []
is_a: GO:0045740 ! positive regulation of DNA replication
is_a: GO:0051347 ! positive regulation of transferase activity
is_a: GO:0051972 ! regulation of telomerase activity
is_a: GO:2000573 ! positive regulation of DNA biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003720 ! telomerase activity
relationship: positively_regulates GO:0003720 ! telomerase activity

[Term]
id: GO:0051974
name: negative regulation of telomerase activity
namespace: biological_process
def: "Any process that stops or reduces the activity of the enzyme telomerase, which catalyzes of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)." [GOC:ai]
synonym: "down regulation of telomerase activity" EXACT []
synonym: "down-regulation of telomerase activity" EXACT []
synonym: "downregulation of telomerase activity" EXACT []
synonym: "inhibition of telomerase activity" NARROW []
synonym: "telomerase inhibitor" RELATED []
is_a: GO:0008156 ! negative regulation of DNA replication
is_a: GO:0051348 ! negative regulation of transferase activity
is_a: GO:0051972 ! regulation of telomerase activity
is_a: GO:2000279 ! negative regulation of DNA biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003720 ! telomerase activity
relationship: negatively_regulates GO:0003720 ! telomerase activity

[Term]
id: GO:0051975
name: lysine biosynthetic process via alpha-aminoadipate and saccharopine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lysine via the intermediates alpha-aminoadipic acid and saccharopine. This pathway is used by yeast and fungi to synthesize the essential amino acid L-lysine, and pathway intermediates are often incorporated into secondary metabolic processes. The pathway proceeds as follows: alpha-ketoglutarate is converted to homocitrate, which is metabolized to 3-carboxyhex-2-enedioate and then homoisocitrate. This is then decarboxylated to form alpha-ketoadipate, which is then converted to alpha-aminoadipate. This is then reduced to form alpha-aminoadipate 6-semialdehyde, which is metabolized to saccharopine and finally L-lysine." [MetaCyc:LYSINE-AMINOAD-PWY]
synonym: "lysine biosynthesis via aminoadipic acid and saccharopine" EXACT []
synonym: "lysine biosynthetic process via aminoadipic acid and saccharopine" EXACT []
xref: MetaCyc:LYSINE-AMINOAD-PWY
is_a: GO:0019878 ! lysine biosynthetic process via aminoadipic acid

[Term]
id: GO:0051976
name: lysine biosynthetic process via alpha-aminoadipate and N2-acetyl-alpha-aminoadipate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lysine via the intermediates alpha-aminoadipic acid and N2-acetyl-alpha-aminoadipate. This pathway of prokaryotic lysine biosynthesis via alpha-aminoadipate was discovered in the hyper-thermophilic Gram-negative eubacterium Thermus thermophilus. The pathway proceeds as follows: alpha-ketoglutarate is converted to homocitrate, which is metabolized to 3-carboxyhex-2-enedioate and then homoisocitrate. This is then decarboxylated to form alpha-ketoadipate, which is then converted to alpha-aminoadipate. This undergoes acetylation, to form N2-acetyl-alpha-aminoadipate, and is then phosphorylated to give N2-acetyl-alpha-aminoadipyl-delta-phosphate. This is converted to N2-acetyl-alpha-aminoadipate semialdehyde, which is then converted to N2-acetyl-L-lysine. A final deacetylation reaction produces L-lysine." [MetaCyc:PWY-3081]
synonym: "lysine biosynthesis via aminoadipic acid and N2-acetyl-alpha-aminoadipate" EXACT []
synonym: "lysine biosynthetic process via aminoadipic acid and N2-acetyl-alpha-aminoadipate" EXACT []
xref: MetaCyc:PWY-3081
is_a: GO:0019878 ! lysine biosynthetic process via aminoadipic acid

[Term]
id: GO:0051977
name: lysophospholipid transport
namespace: biological_process
def: "The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A lysophospholipid is a phospholipid that lacks one of its fatty acyl chains; it is an intermediate formed during digestion of dietary and biliary phospholipids." [GOC:ai]
is_a: GO:0015914 ! phospholipid transport
is_a: GO:1901264 ! carbohydrate derivative transport

[Term]
id: GO:0051978
name: lysophospholipid transporter activity
namespace: molecular_function
def: "Enables the directed movement of lysophospholipids into, out of or within a cell, or between cells. A lysophospholipid is a phospholipid that lacks one of its fatty acyl chains; it is an intermediate formed during digestion of dietary and biliary phospholipids." [GOC:ai]
subset: gosubset_prok
is_a: GO:0005548 ! phospholipid transporter activity
is_a: GO:1901505 ! carbohydrate derivative transporter activity
relationship: part_of GO:0051977 ! lysophospholipid transport

[Term]
id: GO:0051979
name: alginic acid acetylation
namespace: biological_process
def: "The addition of O-acetyl ester groups to alginic acid, a linear polymer of D-mannuronate and L-guluronate." [GOC:mlg]
synonym: "alginate acetylation" EXACT []
is_a: GO:0042120 ! alginic acid metabolic process

[Term]
id: GO:0051980
name: iron-nicotianamine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of the iron chelate iron-nicotianamine (Fe-NA) from one side of a membrane to the other." [GOC:ai]
synonym: "Fe-NA chelate transporter activity" EXACT []
is_a: GO:0015603 ! iron chelate transmembrane transporter activity

[Term]
id: GO:0051981
name: copper chelate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a copper chelate from one side of a membrane to the other. A copper chelate is a heterocyclic compound having a metal ion attached by coordinate bonds to at least two nonmetal ions." [http://www.onelook.com]
subset: gosubset_prok
is_a: GO:0005375 ! copper ion transmembrane transporter activity

[Term]
id: GO:0051982
name: copper-nicotianamine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of the copper chelate copper-nicotianamine (Cu-NA) from one side of a membrane to the other." [GOC:ai]
synonym: "Cu-NA chelate transporter activity" EXACT []
is_a: GO:0051981 ! copper chelate transmembrane transporter activity

[Term]
id: GO:0051983
name: regulation of chromosome segregation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai]
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007059 ! chromosome segregation
relationship: regulates GO:0007059 ! chromosome segregation

[Term]
id: GO:0051984
name: positive regulation of chromosome segregation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai]
synonym: "activation of chromosome segregation" NARROW []
synonym: "stimulation of chromosome segregation" NARROW []
synonym: "up regulation of chromosome segregation" EXACT []
synonym: "up-regulation of chromosome segregation" EXACT []
synonym: "upregulation of chromosome segregation" EXACT []
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051983 ! regulation of chromosome segregation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007059 ! chromosome segregation
relationship: positively_regulates GO:0007059 ! chromosome segregation

[Term]
id: GO:0051985
name: negative regulation of chromosome segregation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai]
synonym: "down regulation of chromosome segregation" EXACT []
synonym: "down-regulation of chromosome segregation" EXACT []
synonym: "downregulation of chromosome segregation" EXACT []
synonym: "inhibition of chromosome segregation" NARROW []
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051983 ! regulation of chromosome segregation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007059 ! chromosome segregation
relationship: negatively_regulates GO:0007059 ! chromosome segregation

[Term]
id: GO:0051986
name: negative regulation of attachment of spindle microtubules to kinetochore
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore." [GOC:ai]
synonym: "down regulation of attachment of spindle microtubules to kinetochore" EXACT []
synonym: "down-regulation of attachment of spindle microtubules to kinetochore" EXACT []
synonym: "downregulation of attachment of spindle microtubules to kinetochore" EXACT []
synonym: "inhibition of attachment of spindle microtubules to kinetochore" NARROW []
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0051494 ! negative regulation of cytoskeleton organization
is_a: GO:0051985 ! negative regulation of chromosome segregation
is_a: GO:0051988 ! regulation of attachment of spindle microtubules to kinetochore
is_a: GO:1903828 ! negative regulation of cellular protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008608 ! attachment of spindle microtubules to kinetochore
relationship: negatively_regulates GO:0008608 ! attachment of spindle microtubules to kinetochore

[Term]
id: GO:0051987
name: positive regulation of attachment of spindle microtubules to kinetochore
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore." [GOC:ai]
synonym: "activation of attachment of spindle microtubules to kinetochore" NARROW []
synonym: "stimulation of attachment of spindle microtubules to kinetochore" NARROW []
synonym: "up regulation of attachment of spindle microtubules to kinetochore" EXACT []
synonym: "up-regulation of attachment of spindle microtubules to kinetochore" EXACT []
synonym: "upregulation of attachment of spindle microtubules to kinetochore" EXACT []
is_a: GO:0051495 ! positive regulation of cytoskeleton organization
is_a: GO:0051984 ! positive regulation of chromosome segregation
is_a: GO:0051988 ! regulation of attachment of spindle microtubules to kinetochore
is_a: GO:0090068 ! positive regulation of cell cycle process
is_a: GO:1903829 ! positive regulation of cellular protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008608 ! attachment of spindle microtubules to kinetochore
relationship: positively_regulates GO:0008608 ! attachment of spindle microtubules to kinetochore

[Term]
id: GO:0051988
name: regulation of attachment of spindle microtubules to kinetochore
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore." [GOC:ai]
synonym: "regulation of kinetochore-microtubule attachment" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0051983 ! regulation of chromosome segregation
is_a: GO:0070507 ! regulation of microtubule cytoskeleton organization
is_a: GO:1903827 ! regulation of cellular protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008608 ! attachment of spindle microtubules to kinetochore
relationship: regulates GO:0008608 ! attachment of spindle microtubules to kinetochore

[Term]
id: GO:0051989
name: coproporphyrinogen dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: coproporphyrinogen III + 2 S-adenosyl-L-methionine = protoporphyrinogen IX + 2 CO2 + 2 L-methionine + 2 5'-deoxyadenosine." [EC:1.3.99.22]
synonym: "coproporphyrinogen III oxidase activity" EXACT [EC:1.3.99.22]
synonym: "coproporphyrinogen-III:S-adenosyl-L-methionine oxidoreductase (decarboxylating)" EXACT [EC:1.3.99.22]
synonym: "HemN" RELATED [EC:1.3.99.22]
synonym: "oxygen-independent coproporphyrinogen-III oxidase activity" EXACT []
synonym: "radical SAM enzyme activity" RELATED [EC:1.3.99.22]
xref: EC:1.3.99.22
xref: MetaCyc:HEMN-RXN
xref: RHEA:15428
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0051990
name: (R)-2-hydroxyglutarate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor." [EC:1.1.99.2, MetaCyc:2-HYDROXYGLUTARATE-DEHYDROGENASE-RXN]
subset: gosubset_prok
synonym: "D-2-hydroxyglutarate dehydrogenase activity" EXACT []
xref: EC:1.1.1.-
xref: Reactome:REACT_25008 "2-oxoglutarate + NADPH + H+ => (R)-2-hydroxyglutarate + NADP+ [mutant IDH1], Homo sapiens"
xref: Reactome:REACT_25270 "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2, Homo sapiens"
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0051991
name: UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol + UDP-N-acetyl-D-glucosamine = N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine + UDP." [MetaCyc:NACGLCTRANS-RXN]
comment: Note that EC classifies 'UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity ; GO:0051991' and 'undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity ; GO:0050511' under the same EC number, EC:2.4.1.227.
subset: gosubset_prok
xref: EC:2.4.1.227
xref: MetaCyc:NACGLCTRANS-RXN
is_a: GO:0008375 ! acetylglucosaminyltransferase activity
created_by: gwg
creation_date: 2010-07-06T11:53:19Z

[Term]
id: GO:0051992
name: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine + di-trans,poly-cis-undecaprenyl phosphate = UMP + N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol." [EC:2.7.8.13, MetaCyc:PHOSNACMURPENTATRANS-RXN]
comment: Note that EC classifies 'UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity ; GO:0051992' and 'phospho-N-acetylmuramoyl-pentapeptide-transferase activity ; GO:0008963' under the same EC number, EC:2.7.8.13.
subset: goslim_chembl
subset: gosubset_prok
xref: EC:2.7.8.13
xref: MetaCyc:PHOSNACMURPENTATRANS-RXN
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups
created_by: gwg
creation_date: 2010-07-06T12:10:01Z

[Term]
id: GO:0051993
name: abscisic acid glucose ester beta-glucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: abscisic acid glucose ester + H2O = abscisic acid + beta-D-glucose." [PMID:16990135]
synonym: "ABA-GE beta-glucosidase activity" EXACT []
is_a: GO:0008422 ! beta-glucosidase activity
created_by: gwg
creation_date: 2010-07-16T02:16:59Z

[Term]
id: GO:0051994
name: P-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group to the phosphorus atom of an acceptor molecule." [GOC:ai]
xref: EC:2.1.1.-
is_a: GO:0008168 ! methyltransferase activity
created_by: gwg
creation_date: 2010-07-16T04:39:34Z

[Term]
id: GO:0051995
name: Se-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group to the selenium atom of an acceptor molecule." [GOC:ai]
xref: EC:2.1.1.-
is_a: GO:0008168 ! methyltransferase activity
created_by: gwg
creation_date: 2010-07-16T04:48:08Z

[Term]
id: GO:0051996
name: squalene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: presqualene diphosphate + NADPH = squalene + NADP+ + diphosphate." [EC:2.5.1.21]
comment: Note that the two reactions performed by EC:2.5.1.21 are represented in GO by 'farnesyl-diphosphate farnesyltransferase activity ; GO:0004310' and 'squalene synthase activity ; GO:0051996'.
subset: gosubset_prok
synonym: "squalene synthetase activity" EXACT [EC:2.5.1.21]
xref: EC:2.5.1.21
xref: MetaCyc:RXN66-281
is_a: GO:0004311 ! farnesyltranstransferase activity
created_by: gwg
creation_date: 2010-07-16T05:10:24Z

[Term]
id: GO:0051997
name: 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H imidazole-5-carboxylate + H+ = S-allantoin + CO2." [MetaCyc:RXN-6201]
synonym: "4-(carbamoylamino)-5-hydroxy-2-oxo-2,5-dihydro-1H-imidazole-5-carboxylate decarboxylase activity" EXACT []
synonym: "OHCU decarboxylase activity" EXACT []
xref: EC:4.1.1.-
xref: KEGG:R06604
xref: MetaCyc:RXN-6201
is_a: GO:0016831 ! carboxy-lyase activity
created_by: gwg
creation_date: 2010-07-19T10:47:15Z

[Term]
id: GO:0051998
name: protein carboxyl O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group to a carboxyl group on a protein." [GOC:ai]
synonym: "protein carboxyl methyltransferase activity" EXACT []
is_a: GO:0008276 ! protein methyltransferase activity
is_a: GO:0010340 ! carboxyl-O-methyltransferase activity
created_by: gwg
creation_date: 2010-07-20T09:23:00Z

[Term]
id: GO:0051999
name: mannosyl-inositol phosphorylceramide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of mannosyl-inositol phosphorylceramide, any lipid with a phosphodiester bridge between an inositol residue and the ceramide group which contains a phosphoryl (-P(O)=) groups and a mannose derivative." [GOC:ai]
synonym: "mannose inositol phosphoceramide biosynthetic process" EXACT []
synonym: "mannose-inositol-P-ceramide (MIPC) biosynthetic process" EXACT []
synonym: "mannosyl-inositol phosphorylceramide anabolism" EXACT []
synonym: "mannosyl-inositol phosphorylceramide biosynthesis" EXACT []
synonym: "mannosyl-inositol phosphorylceramide formation" EXACT []
synonym: "mannosyl-inositol phosphorylceramide synthesis" EXACT []
synonym: "MIPC biosynthetic process" EXACT []
is_a: GO:0006675 ! mannosyl-inositol phosphorylceramide metabolic process
is_a: GO:0006688 ! glycosphingolipid biosynthetic process
is_a: GO:0008654 ! phospholipid biosynthetic process
created_by: gwg
creation_date: 2010-07-20T10:16:26Z

[Term]
id: GO:0052000
name: Type IV pili-dependent aggregation
namespace: biological_process
def: "The formation of bacterial aggregates in liquid culture dependent on the presence of Type IV pili." [GOC:ml]
subset: gosubset_prok
synonym: "auto-aggregation" BROAD []
synonym: "bfp-dependent aggregation" EXACT []
synonym: "bundle-forming fimbriae-dependent aggregation" EXACT []
synonym: "bundle-forming pili-dependent aggregation" EXACT []
synonym: "tfp-dependent aggregation" EXACT []
is_a: GO:0098630 ! aggregation of unicellular organisms

[Term]
id: GO:0052001
name: Type IV pili-dependent localized adherence to host
namespace: biological_process
def: "Attachment of bacterial clusters to the surface of the host in a type IV pili dependent manner. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:ml]
subset: gosubset_prok
is_a: GO:0044406 ! adhesion of symbiont to host

[Term]
id: GO:0052002
name: metabolism by symbiont of substance in host
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0044003 ! modification by symbiont of host morphology or physiology
is_a: GO:0052214 ! metabolism of substance in other organism involved in symbiotic interaction

[Term]
id: GO:0052003
name: negative regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of host salicylic acid-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" EXACT []
synonym: "down-regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" EXACT []
synonym: "downregulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" EXACT []
synonym: "inhibition by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" NARROW []
synonym: "negative modulation by organism of defense-related host SA-mediated signal transduction pathway" EXACT []
synonym: "negative modulation by organism of defense-related host salicylic acid-mediated signal transduction pathway" EXACT []
synonym: "negative regulation by organism of defense-related host SA-mediated signal transduction pathway" EXACT []
is_a: GO:0052004 ! negative regulation by symbiont of host salicylic acid-mediated defense response
is_a: GO:0052029 ! negative regulation by symbiont of host signal transduction pathway
is_a: GO:0052081 ! modulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway
is_a: GO:0052252 ! negative regulation by organism of defense-related salicylic acid-mediated signal transduction pathway of other organism involved in symbiotic interaction

[Term]
id: GO:0052004
name: negative regulation by symbiont of host salicylic acid-mediated defense response
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the salicylic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by symbiont of host salicylic acid-mediated defense response" EXACT []
synonym: "down-regulation by symbiont of host salicylic acid-mediated defense response" EXACT []
synonym: "downregulation by symbiont of host salicylic acid-mediated defense response" EXACT []
synonym: "inhibition by symbiont of host salicylic acid-mediated defense response" NARROW []
synonym: "negative regulation of host SA-mediated defense response" EXACT []
synonym: "suppression by organism of host salicylic acid-mediated defense response" EXACT []
synonym: "suppression of host SA mediated defense response" EXACT []
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0010113 ! negative regulation of systemic acquired resistance
is_a: GO:0052037 ! negative regulation by symbiont of host defense response
is_a: GO:0052089 ! modulation by symbiont of host salicylic acid-mediated defense response
is_a: GO:0052253 ! negative regulation by organism of salicylic acid-mediated defense response of other organism involved in symbiotic interaction
relationship: negatively_regulates GO:0009862 ! systemic acquired resistance, salicylic acid mediated signaling pathway

[Term]
id: GO:0052005
name: negative regulation by symbiont of host ethylene-mediated defense response
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the ethylene-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by symbiont of host ethylene-mediated defense response" EXACT []
synonym: "down-regulation by symbiont of host ethylene-mediated defense response" EXACT []
synonym: "downregulation by symbiont of host ethylene-mediated defense response" EXACT []
synonym: "inhibition by symbiont of host ethylene-mediated defense response" NARROW []
synonym: "suppression by organism of host ethylene-mediated defense response" EXACT []
is_a: GO:0052037 ! negative regulation by symbiont of host defense response
is_a: GO:0052084 ! modulation by symbiont of host ethylene-mediated defense response
is_a: GO:0052254 ! negative regulation by organism of ethylene-mediated defense response of other organism involved in symbiotic interaction

[Term]
id: GO:0052006
name: catabolism by symbiont of substance in host
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism in its host resulting in the breakdown of substances. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
synonym: "catabolism by organism of substance in host" EXACT []
is_a: GO:0052002 ! metabolism by symbiont of substance in host
is_a: GO:0052227 ! catabolism of substance in other organism involved in symbiotic interaction

[Term]
id: GO:0052007
name: biosynthesis by symbiont of substance in host
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism in its host resulting in the formation of substances. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
synonym: "biosynthesis by organism of substance in host" EXACT []
is_a: GO:0052002 ! metabolism by symbiont of substance in host
is_a: GO:0052226 ! biosynthesis of substance in other organism involved in symbiotic interaction

[Term]
id: GO:0052008
name: disruption by symbiont of host cellular component
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of cellular components of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
subset: gosubset_prok
synonym: "catabolism of host cellular component by organism" EXACT []
synonym: "catabolism of host structural constituent by organism" EXACT []
synonym: "degradation of host cellular component by organism" EXACT []
synonym: "disassembly by organism of host cellular component" EXACT []
synonym: "disassembly by symbiont of host cellular component" RELATED []
is_a: GO:0052043 ! modification by symbiont of host cellular component
is_a: GO:0052368 ! disruption by organism of cellular component in other organism involved in symbiotic interaction

[Term]
id: GO:0052009
name: disruption by symbiont of host cell wall
namespace: biological_process
def: "A process carried out by a symbiont that breaks down the cell wall of its host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
subset: gosubset_prok
synonym: "catabolism of host cell wall by organism" EXACT []
synonym: "degradation of host cell wall by organism" EXACT []
synonym: "disassembly by organism of host cell wall" EXACT []
synonym: "disassembly by symbiont of host cell wall" EXACT []
is_a: GO:0098933 ! disruption by symbiont of host cell envelope

[Term]
id: GO:0052010
name: catabolism by symbiont of host cell wall cellulose
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of cellulose in the host cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
subset: gosubset_prok
synonym: "catabolism by organism of host cell wall cellulose" EXACT []
is_a: GO:0052015 ! catabolism by symbiont of host carbohydrate
is_a: GO:0052172 ! metabolism by symbiont of host cell wall cellulose
is_a: GO:0052340 ! catabolism by organism of cell wall cellulose in other organism involved in symbiotic interaction
relationship: part_of GO:0052009 ! disruption by symbiont of host cell wall

[Term]
id: GO:0052011
name: catabolism by symbiont of host cell wall pectin
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of pectin in the host cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
subset: gosubset_prok
synonym: "catabolism by organism of host cell wall pectin" EXACT []
is_a: GO:0052015 ! catabolism by symbiont of host carbohydrate
is_a: GO:0052179 ! metabolism by symbiont of host cell wall pectin
is_a: GO:0052341 ! catabolism by organism of cell wall pectin in other organism involved in symbiotic interaction
relationship: part_of GO:0052009 ! disruption by symbiont of host cell wall

[Term]
id: GO:0052012
name: catabolism by symbiont of host cell wall chitin
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of chitin in the host cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
subset: gosubset_prok
synonym: "catabolism by organism of host cell wall chitin" EXACT []
is_a: GO:0052015 ! catabolism by symbiont of host carbohydrate
is_a: GO:0052178 ! metabolism by symbiont of host cell wall chitin
is_a: GO:0052342 ! catabolism by organism of cell wall chitin in other organism involved in symbiotic interaction
relationship: part_of GO:0052009 ! disruption by symbiont of host cell wall

[Term]
id: GO:0052013
name: catabolism by symbiont of host macromolecule
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of macromolecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
synonym: "catabolism by organism of host macromolecule" EXACT []
is_a: GO:0052006 ! catabolism by symbiont of substance in host
is_a: GO:0052174 ! metabolism by symbiont of host macromolecule
is_a: GO:0052361 ! catabolism by organism of macromolecule in other organism involved in symbiotic interaction

[Term]
id: GO:0052014
name: catabolism by symbiont of host protein
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of protein macromolecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
synonym: "catabolism by organism of host protein" EXACT []
is_a: GO:0052013 ! catabolism by symbiont of host macromolecule
is_a: GO:0052228 ! metabolism by symbiont of host protein
is_a: GO:0052363 ! catabolism by organism of protein in other organism involved in symbiotic interaction

[Term]
id: GO:0052015
name: catabolism by symbiont of host carbohydrate
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of carbohydrate molecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
synonym: "catabolism by organism of host carbohydrate" EXACT []
is_a: GO:0052013 ! catabolism by symbiont of host macromolecule
is_a: GO:0052175 ! metabolism by symbiont of host carbohydrate
is_a: GO:0052354 ! catabolism by organism of carbohydrate in other organism involved in symbiotic interaction

[Term]
id: GO:0052016
name: catabolism by symbiont of host glucan
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of glucan molecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
synonym: "catabolism by organism of host glucan" EXACT []
is_a: GO:0052015 ! catabolism by symbiont of host carbohydrate
is_a: GO:0052176 ! metabolism by symbiont of host glucan
is_a: GO:0052359 ! catabolism by organism of glucan in other organism involved in symbiotic interaction

[Term]
id: GO:0052017
name: catabolism by symbiont of host xylan
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of xylan within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
synonym: "catabolism by organism of host xylan" EXACT []
is_a: GO:0052015 ! catabolism by symbiont of host carbohydrate
is_a: GO:0052177 ! metabolism by symbiont of host xylan
is_a: GO:0052366 ! catabolism by organism of xylan in other organism involved in symbiotic interaction

[Term]
id: GO:0052018
name: modulation by symbiont of RNA levels in host
namespace: biological_process
def: "The alteration by an organism of the levels of RNA in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by symbiont of host RNA levels" EXACT []
is_a: GO:0044003 ! modification by symbiont of host morphology or physiology
is_a: GO:0052249 ! modulation of RNA levels in other organism involved in symbiotic interaction

[Term]
id: GO:0052019
name: modulation by symbiont of host hormone or growth regulator levels
namespace: biological_process
def: "The alteration by an organism of the levels of hormones or growth regulators in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0044003 ! modification by symbiont of host morphology or physiology
is_a: GO:0052186 ! modulation by organism of hormone or growth regulator levels in other organism involved in symbiotic interaction

[Term]
id: GO:0052020
name: modification by symbiont of host cell wall
namespace: biological_process
def: "The process in which an organism effects a change in the structure or function of the host cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
subset: gosubset_prok
synonym: "metabolism of host cell wall by organism" EXACT []
is_a: GO:0052043 ! modification by symbiont of host cellular component
is_a: GO:0052333 ! modification by organism of cell wall of other organism involved in symbiotic interaction

[Term]
id: GO:0052021
name: modulation by symbiont of ethylene levels in host
namespace: biological_process
def: "The alteration by an organism of the levels of ethylene in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052019 ! modulation by symbiont of host hormone or growth regulator levels
is_a: GO:0052449 ! modulation by organism of ethylene levels in other organism involved in symbiotic interaction

[Term]
id: GO:0052022
name: modulation by symbiont of jasmonic acid levels in host
namespace: biological_process
def: "The alteration by an organism of the levels of jasmonic acid in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052019 ! modulation by symbiont of host hormone or growth regulator levels
is_a: GO:0052456 ! modulation by organism of jasmonic acid levels in other organism involved in symbiotic interaction

[Term]
id: GO:0052023
name: modulation by symbiont of salicylic acid levels in host
namespace: biological_process
def: "The alteration by an organism of the levels of salicylic acid in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052019 ! modulation by symbiont of host hormone or growth regulator levels
is_a: GO:0052469 ! modulation by organism of salicylic acid levels in other organism involved in symbiotic interaction

[Term]
id: GO:0052024
name: positive regulation by symbiont of hormone or growth regulator levels in host
namespace: biological_process
def: "The increase by an organism of the levels of hormones or growth regulators in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by symbiont of hormone or growth regulator levels in host" NARROW []
synonym: "positive modulation of hormone or growth regulator levels in host" EXACT []
synonym: "stimulation by symbiont of hormone or growth regulator levels in host" NARROW []
synonym: "up regulation by symbiont of hormone or growth regulator levels in host" EXACT []
synonym: "up-regulation by symbiont of hormone or growth regulator levels in host" EXACT []
synonym: "upregulation by symbiont of hormone or growth regulator levels in host" EXACT []
is_a: GO:0052019 ! modulation by symbiont of host hormone or growth regulator levels
is_a: GO:0052513 ! positive regulation by organism of hormone or growth regulator levels in other organism involved in symbiotic interaction

[Term]
id: GO:0052025
name: modification by symbiont of host cell membrane
namespace: biological_process
def: "The process in which an organism effects a change in the structure or function of a host cellular membrane. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modification by symbiont of host cell membrane" NARROW [GOC:bf, GOC:jl]
is_a: GO:0052043 ! modification by symbiont of host cellular component
is_a: GO:0052332 ! modification by organism of membrane in other organism involved in symbiotic interaction

[Term]
id: GO:0052026
name: modulation by symbiont of host transcription
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of its host's transcription. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0044068 ! modulation by symbiont of host cellular process
is_a: GO:0052312 ! modulation of transcription in other organism involved in symbiotic interaction

[Term]
id: GO:0052027
name: modulation by symbiont of host signal transduction pathway
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of the host signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by symbiont of host signal transduction" RELATED []
synonym: "modulation of host signal transduction by symbiont" EXACT []
synonym: "regulation by symbiont of host signal transduction pathway" EXACT []
is_a: GO:0044068 ! modulation by symbiont of host cellular process
is_a: GO:0052250 ! modulation of signal transduction in other organism involved in symbiotic interaction

[Term]
id: GO:0052028
name: positive regulation by symbiont of host signal transduction pathway
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the host signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by symbiont of host signal transduction pathway" NARROW []
synonym: "stimulation by symbiont of host signal transduction pathway" NARROW []
synonym: "up regulation by symbiont of host signal transduction pathway" EXACT []
synonym: "up-regulation by symbiont of host signal transduction pathway" EXACT []
synonym: "upregulation by symbiont of host signal transduction pathway" EXACT []
is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway
is_a: GO:0052526 ! positive regulation by organism of signal transduction in other organism involved in symbiotic interaction

[Term]
id: GO:0052029
name: negative regulation by symbiont of host signal transduction pathway
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the host signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by symbiont of host signal transduction pathway" EXACT []
synonym: "down-regulation by symbiont of host signal transduction pathway" EXACT []
synonym: "downregulation by symbiont of host signal transduction pathway" EXACT []
synonym: "inhibition by symbiont of host signal transduction pathway" NARROW []
synonym: "negative modulation by organism of host signal transduction pathway" EXACT []
is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway
is_a: GO:0052493 ! negative regulation by organism of signal transduction in other organism involved in symbiotic interaction

[Term]
id: GO:0052031
name: modulation by symbiont of host defense response
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of the defense response of its host, the response mounted by the host in response to the presence of the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0044003 ! modification by symbiont of host morphology or physiology
is_a: GO:0052200 ! response to host defenses
is_a: GO:0052255 ! modulation by organism of defense response of other organism involved in symbiotic interaction

[Term]
id: GO:0052032
name: modulation by symbiont of host inflammatory response
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of the inflammatory response of the host organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052031 ! modulation by symbiont of host defense response
is_a: GO:0052256 ! modulation by organism of inflammatory response of other organism involved in symbiotic interaction

[Term]
id: GO:0052033
name: pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response
namespace: biological_process
def: "Any process that involves recognition of a pathogen-associated molecular pattern, and by which an organism activates, maintains or increases the frequency, rate or extent of the innate immune response of the host organism; the innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mah]
subset: gosubset_prok
synonym: "general elicitor-dependent activation of host innate immunity" EXACT []
synonym: "general elicitor-dependent induction of host innate immunity" EXACT []
synonym: "MAMP dependent activation of host innate immunity" EXACT []
synonym: "MAMP dependent induction of host innate immunity" EXACT []
synonym: "PAMP dependent activation of host innate immunity" EXACT []
synonym: "PAMP dependent induction of host innate immunity" EXACT []
synonym: "pathogen-associated molecular pattern dependent activation by organism of host innate immunity" EXACT []
synonym: "pathogen-associated molecular pattern dependent induction by symbiont of host innate immunity" EXACT [GOC:pg]
is_a: GO:0052166 ! positive regulation by symbiont of host innate immune response
is_a: GO:0052169 ! pathogen-associated molecular pattern dependent modulation by symbiont of host innate immune response
is_a: GO:0052257 ! pathogen-associated molecular pattern dependent induction by organism of innate immune response of other organism involved in symbiotic interaction

[Term]
id: GO:0052034
name: negative regulation by symbiont of microbe-associated molecular pattern-induced host innate immune response
namespace: biological_process
def: "Any process that involves recognition of a microbe-associated molecular pattern, and by which an organism tops, prevents, or reduces the frequency, rate or extent of the innate immune response of the host organism; the innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation by symbiont of pathogen-associated molecular pattern-induced host innate immunity" EXACT []
synonym: "down-regulation by symbiont of pathogen-associated molecular pattern-induced host innate immunity" EXACT []
synonym: "downregulation by symbiont of pathogen-associated molecular pattern-induced host innate immunity" EXACT []
synonym: "inhibition by symbiont of pathogen-associated molecular pattern-induced host innate immunity" NARROW []
synonym: "negative regulation by symbiont of microbe-associated molecular pattern-induced host innate immunity" EXACT [GOC:pg]
synonym: "suppression of general elicitor induced host innate immunity" EXACT []
synonym: "suppression of general elicitor-induced host innate immunity" EXACT []
synonym: "suppression of MAMP induced host innate immunity" EXACT []
synonym: "suppression of MAMP-induced host innate immunity" EXACT []
synonym: "suppression of PAMP induced host innate immunity" EXACT []
synonym: "suppression of PAMP-induced host innate immunity" EXACT []
synonym: "suppression of pathogen-associated molecular pattern-induced host innate immunity" EXACT []
is_a: GO:0052157 ! modulation by symbiont of microbe-associated molecular pattern-induced host innate immune response
is_a: GO:0052170 ! negative regulation by symbiont of host innate immune response
is_a: GO:0052258 ! negative regulation by organism of pathogen-associated molecular pattern-induced innate immune response of other organism involved in symbiotic interaction

[Term]
id: GO:0052035
name: positive regulation by symbiont of host inflammatory response
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the inflammatory response of the host organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by symbiont of host inflammatory response" NARROW []
synonym: "stimulation by symbiont of host inflammatory response" NARROW []
synonym: "up regulation by symbiont of host inflammatory response" EXACT []
synonym: "up-regulation by symbiont of host inflammatory response" EXACT []
synonym: "upregulation by symbiont of host inflammatory response" EXACT []
is_a: GO:0052032 ! modulation by symbiont of host inflammatory response
is_a: GO:0052259 ! positive regulation by organism of inflammatory response of other organism involved in symbiotic interaction
is_a: GO:0052509 ! positive regulation by symbiont of host defense response

[Term]
id: GO:0052036
name: negative regulation by symbiont of host inflammatory response
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the inflammatory response of the host organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by symbiont of host inflammatory response" EXACT []
synonym: "down-regulation by symbiont of host inflammatory response" EXACT []
synonym: "downregulation by symbiont of host inflammatory response" EXACT []
synonym: "inhibition by symbiont of host inflammatory response" NARROW []
is_a: GO:0052032 ! modulation by symbiont of host inflammatory response
is_a: GO:0052037 ! negative regulation by symbiont of host defense response
is_a: GO:0052260 ! negative regulation by organism of inflammatory response of other organism involved in symbiotic interaction

[Term]
id: GO:0052037
name: negative regulation by symbiont of host defense response
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by symbiont of host defense response" EXACT []
synonym: "down-regulation by symbiont of host defense response" EXACT []
synonym: "downregulation by symbiont of host defense response" EXACT []
synonym: "inhibition by symbiont of host defense response" NARROW []
synonym: "suppression of host defense response" EXACT []
is_a: GO:0044414 ! suppression of host defenses
is_a: GO:0052031 ! modulation by symbiont of host defense response
is_a: GO:0052261 ! suppression of defense response of other organism involved in symbiotic interaction

[Term]
id: GO:0052038
name: modulation by symbiont of host intracellular transport
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of the directed movement of substances within the cell or cells of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation of host intracellular trafficking" EXACT []
is_a: GO:0044068 ! modulation by symbiont of host cellular process
is_a: GO:0052230 ! modulation of intracellular transport in other organism involved in symbiotic interaction
intersection_of: GO:0044068 ! modulation by symbiont of host cellular process
intersection_of: regulates GO:0046907 ! intracellular transport
relationship: regulates GO:0046907 ! intracellular transport

[Term]
id: GO:0052039
name: modification by symbiont of host cytoskeleton
namespace: biological_process
def: "The process in which an organism effects a change in the structure or function of the host cytoskeleton. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052043 ! modification by symbiont of host cellular component
is_a: GO:0052334 ! modification by organism of cytoskeleton of other organism involved in symbiotic interaction

[Term]
id: GO:0052040
name: modulation by symbiont of host programmed cell death
namespace: biological_process
alt_id: GO:0052152
def: "Any process in which an organism modulates the frequency, rate or extent of programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by symbiont of host non-apoptotic programmed cell death" NARROW []
synonym: "modulation of host PCD" EXACT []
is_a: GO:0044068 ! modulation by symbiont of host cellular process
is_a: GO:0052248 ! modulation of programmed cell death in other organism involved in symbiotic interaction

[Term]
id: GO:0052041
name: negative regulation by symbiont of host programmed cell death
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by symbiont of host programmed cell death" EXACT []
synonym: "down-regulation by symbiont of host programmed cell death" EXACT []
synonym: "downregulation by symbiont of host programmed cell death" EXACT []
synonym: "inhibition by symbiont of host programmed cell death" NARROW []
synonym: "inhibition of host programmed cell death" EXACT []
synonym: "suppression by symbiont of host PCD" EXACT []
synonym: "suppression by symbiont of host programmed cell death" EXACT []
is_a: GO:0052040 ! modulation by symbiont of host programmed cell death
is_a: GO:0052490 ! negative regulation by organism of programmed cell death in other organism involved in symbiotic interaction

[Term]
id: GO:0052042
name: positive regulation by symbiont of host programmed cell death
namespace: biological_process
alt_id: GO:0012504
alt_id: GO:0052044
alt_id: GO:0052045
alt_id: GO:0052153
alt_id: GO:0052397
alt_id: GO:0052400
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of host programmed cell death" EXACT []
synonym: "activation by organism of non-apoptotic programmed cell death in other organism" NARROW []
synonym: "activation by organism of programmed cell death in other organism during symbiotic interaction" EXACT []
synonym: "activation by symbiont of host programmed cell death" NARROW []
synonym: "enhancement of host programmed cell death" EXACT []
synonym: "enhancement of host programmed cell death by organism" EXACT []
synonym: "induction by organism of non-apoptotic programmed cell death in other organism during symbiotic interaction" NARROW []
synonym: "induction by organism of programmed cell death in other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "induction by organism of programmed cell death in other organism involved in symbiotic interaction" EXACT []
synonym: "induction by symbiont of host programmed cell death" EXACT []
synonym: "induction of non-apoptotic programmed cell death by other organism" RELATED []
synonym: "positive regulation by symbiont of host non-apoptotic programmed cell death" NARROW []
synonym: "stimulation by symbiont of host programmed cell death" NARROW []
synonym: "upregulation by symbiont of host programmed cell death" EXACT []
is_a: GO:0012502 ! induction of programmed cell death
is_a: GO:0052040 ! modulation by symbiont of host programmed cell death
is_a: GO:0052330 ! positive regulation by organism of programmed cell death in other organism involved in symbiotic interaction
relationship: part_of GO:0001907 ! killing by symbiont of host cells

[Term]
id: GO:0052043
name: modification by symbiont of host cellular component
namespace: biological_process
def: "The process in which an organism effects a change in the structure or function of a host cellular component. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052111 ! modification by symbiont of host structure
is_a: GO:0052188 ! modification of cellular component in other organism involved in symbiotic interaction

[Term]
id: GO:0052046
name: modification by symbiont of host morphology or physiology via secreted substance
namespace: biological_process
def: "The process in which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by one of the organisms. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modification of host morphology or physiology via effector molecule" NARROW []
synonym: "modification of host morphology or physiology via ellicitor" NARROW []
is_a: GO:0044003 ! modification by symbiont of host morphology or physiology
is_a: GO:0052048 ! interaction with host via secreted substance involved in symbiotic interaction
is_a: GO:0052212 ! modification of morphology or physiology of other organism via secreted substance involved in symbiotic interaction

[Term]
id: GO:0052047
name: interaction with other organism via secreted substance involved in symbiotic interaction
namespace: biological_process
def: "An interaction with a second organism mediated by a substance secreted by the first organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "interaction with other organism via secreted substance during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0044419 ! interspecies interaction between organisms
relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism

[Term]
id: GO:0052048
name: interaction with host via secreted substance involved in symbiotic interaction
namespace: biological_process
def: "An interaction with the host organism mediated by a substance secreted by the other (symbiont) organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "interaction with host via secreted substance during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0044046 ! interaction with host via substance released outside of symbiont
is_a: GO:0052047 ! interaction with other organism via secreted substance involved in symbiotic interaction

[Term]
id: GO:0052049
name: interaction with host via protein secreted by type III secretion system
namespace: biological_process
def: "An interaction with the host organism mediated by a substance secreted by the symbiont organism by a type III secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052048 ! interaction with host via secreted substance involved in symbiotic interaction
is_a: GO:0052210 ! interaction with other organism via protein secreted by type III secretion system involved in symbiotic interaction

[Term]
id: GO:0052050
name: interaction with host via substance secreted by type IV secretion system
namespace: biological_process
def: "An interaction with the host organism mediated by a substance secreted by the other organism by a type IV secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052048 ! interaction with host via secreted substance involved in symbiotic interaction
is_a: GO:0052209 ! interaction with other organism via substance secreted by type IV secretion system involved in symbiotic interaction

[Term]
id: GO:0052051
name: interaction with host via protein secreted by type II secretion system
namespace: biological_process
def: "An interaction with the host organism mediated by a substance secreted by the other organism by a type II secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052048 ! interaction with host via secreted substance involved in symbiotic interaction
is_a: GO:0052211 ! interaction with other organism via protein secreted by type II secretion system involved in symbiotic interaction

[Term]
id: GO:0052052
name: modification by symbiont of host morphology or physiology via protein secreted by type II secretion system
namespace: biological_process
def: "The process in which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by a type II secretion system in the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052046 ! modification by symbiont of host morphology or physiology via secreted substance
is_a: GO:0052051 ! interaction with host via protein secreted by type II secretion system
is_a: GO:0052206 ! modification of morphology or physiology of other organism via protein secreted by type II secretion system involved in symbiotic interaction

[Term]
id: GO:0052053
name: negative regulation by symbiont of host catalytic activity
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of host enzyme activity. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by symbiont of host enzyme activity" EXACT []
synonym: "down-regulation by symbiont of host enzyme activity" EXACT []
synonym: "downregulation by symbiont of host enzyme activity" EXACT []
synonym: "inhibition by symbiont of host enzyme activity" NARROW []
synonym: "inhibition of host enzyme activity" EXACT []
synonym: "negative regulation by symbiont of host enzyme activity" EXACT []
is_a: GO:0052056 ! negative regulation by symbiont of host molecular function
is_a: GO:0052148 ! modulation by symbiont of host catalytic activity
is_a: GO:0052199 ! negative regulation of catalytic activity in other organism involved in symbiotic interaction
intersection_of: GO:0052056 ! negative regulation by symbiont of host molecular function
intersection_of: negatively_regulates GO:0003824 ! catalytic activity
relationship: negatively_regulates GO:0003824 ! catalytic activity

[Term]
id: GO:0052054
name: negative regulation by symbiont of host peptidase activity
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of host protease activity, the catalysis of the hydrolysis of peptide bonds in a protein. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb]
subset: gosubset_prok
synonym: "down regulation by symbiont of host protease activity" NARROW []
synonym: "down-regulation by symbiont of host protease activity" NARROW []
synonym: "downregulation by symbiont of host protease activity" NARROW []
synonym: "inhibition by symbiont of host protease activity" NARROW []
synonym: "inhibition of host protease activity" NARROW []
synonym: "negative regulation by symbiont of host protease activity" NARROW [GOC:dph, GOC:tb]
is_a: GO:0052053 ! negative regulation by symbiont of host catalytic activity
is_a: GO:0052149 ! modulation by symbiont of host peptidase activity
is_a: GO:0052180 ! negative regulation of peptidase activity in other organism involved in symbiotic interaction

[Term]
id: GO:0052055
name: modulation by symbiont of host molecular function
namespace: biological_process
def: "The process in which an organism effects a change in the function of a host protein via a direct interaction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb]
subset: gosubset_prok
synonym: "modification by symbiont of host molecular function" EXACT []
synonym: "modification by symbiont of host protein function" EXACT [GOC:dph, GOC:tb]
is_a: GO:0044003 ! modification by symbiont of host morphology or physiology
is_a: GO:0052205 ! modulation of molecular function in other organism involved in symbiotic interaction

[Term]
id: GO:0052056
name: negative regulation by symbiont of host molecular function
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the functional activity of host proteins. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb]
subset: gosubset_prok
synonym: "down regulation by symbiont of host protein function" EXACT []
synonym: "down-regulation by symbiont of host protein function" EXACT []
synonym: "downregulation by symbiont of host protein function" EXACT []
synonym: "inhibition by symbiont of host protein function" NARROW []
synonym: "inhibition of host protein function" EXACT []
synonym: "negative regulation by symbiont of host protein function" EXACT [GOC:dph, GOC:tb]
is_a: GO:0052055 ! modulation by symbiont of host molecular function
is_a: GO:0052204 ! negative regulation of molecular function in other organism involved in symbiotic interaction

[Term]
id: GO:0052057
name: modification by symbiont of host morphology or physiology via protein secreted by type III secretion system
namespace: biological_process
def: "The process in which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by a type III secretion system in the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052046 ! modification by symbiont of host morphology or physiology via secreted substance
is_a: GO:0052049 ! interaction with host via protein secreted by type III secretion system
is_a: GO:0052207 ! modification of morphology or physiology of other organism via protein secreted by type III secretion system involved in symbiotic interaction

[Term]
id: GO:0052058
name: modification by symbiont of host morphology or physiology via substance secreted by type IV secretion system
namespace: biological_process
def: "The process in which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by a type IV secretion system in the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052046 ! modification by symbiont of host morphology or physiology via secreted substance
is_a: GO:0052050 ! interaction with host via substance secreted by type IV secretion system
is_a: GO:0052208 ! modification of morphology or physiology of other organism via substance secreted by type IV secretion system involved in symbiotic interaction

[Term]
id: GO:0052059
name: evasion or tolerance by symbiont of host-produced reactive oxygen species
namespace: biological_process
def: "The process in which an organism avoids the effects of reactive oxygen species produced as a defense response by the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "evasion by organism of cellular damage caused by host oxidative burst" NARROW []
synonym: "evasion or tolerance by organism of host-produced reactive oxygen species" EXACT []
synonym: "evasion or tolerance by organism of reactive oxygen species produced during host defense response" EXACT []
synonym: "evasion or tolerance of defense-related host metabolic burst" EXACT []
synonym: "evasion or tolerance of defense-related host oxidative burst" EXACT []
synonym: "evasion or tolerance of defense-related host respiratory burst" EXACT []
synonym: "evasion or tolerance of host-produced active oxygen species" EXACT []
synonym: "evasion or tolerance of host-produced AOS" EXACT []
synonym: "evasion or tolerance of host-produced reactive oxygen intermediates" EXACT []
synonym: "evasion or tolerance of host-produced ROIs" EXACT []
synonym: "evasion or tolerance of host-produced ROS" EXACT []
synonym: "evasion or tolerance of reactive oxygen species produced by host in response to organism" EXACT []
is_a: GO:0020012 ! evasion or tolerance of host immune response
is_a: GO:0052385 ! evasion or tolerance by organism of reactive oxygen species produced by other organism involved in symbiotic interaction
is_a: GO:0052567 ! response to defense-related host reactive oxygen species production

[Term]
id: GO:0052060
name: evasion or tolerance by symbiont of host-produced nitric oxide
namespace: biological_process
def: "The process in which an organism avoids the effects of nitric oxide produced as a defense response by the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "evasion or tolerance by organism of host nitric oxide" EXACT []
synonym: "evasion or tolerance by organism of host NO" EXACT []
synonym: "evasion or tolerance by organism of host-produced nitric oxide" EXACT []
synonym: "evasion or tolerance by organism of host-produced NO" EXACT []
synonym: "evasion or tolerance of nitric oxide produced by host in response to organism" EXACT []
synonym: "evasion or tolerance of NO produced by host in response to organism" EXACT []
is_a: GO:0020012 ! evasion or tolerance of host immune response
is_a: GO:0052376 ! evasion or tolerance by organism of nitric oxide produced by other organism involved in symbiotic interaction
is_a: GO:0052565 ! response to defense-related host nitric oxide production

[Term]
id: GO:0052061
name: evasion or tolerance by symbiont of host-produced phytoalexins
namespace: biological_process
def: "The process in which an organism avoids the effects of phytoalexins produced as a defense response by the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "evasion or tolerance by organism of host phytoalexins" EXACT []
synonym: "evasion or tolerance by organism of host-produced phytoalexins" EXACT []
synonym: "evasion or tolerance of phytoalexins produced by host in response to organism" EXACT []
synonym: "host phytoalexin detoxification" NARROW []
is_a: GO:0020012 ! evasion or tolerance of host immune response
is_a: GO:0052378 ! evasion or tolerance by organism of phytoalexins produced by other organism involved in symbiotic interaction
is_a: GO:0052566 ! response to host phytoalexin production

[Term]
id: GO:0052062
name: induction by symbiont of host phytoalexin production
namespace: biological_process
def: "The activation by an organism of the production of phytoalexins as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of host phytoalexin production" EXACT []
is_a: GO:0052262 ! induction by organism of phytoalexin production in other organism involved in symbiotic interaction
is_a: GO:0052344 ! positive regulation by symbiont of host phytoalexin production
is_a: GO:0052559 ! induction by symbiont of host immune response

[Term]
id: GO:0052063
name: induction by symbiont of defense-related host nitric oxide production
namespace: biological_process
def: "The activation by an organism of the production of nitric oxide as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of defense-related host nitric oxide production" EXACT []
synonym: "activation by organism of defense-related host NO production" EXACT []
synonym: "induction by organism of defense-related host NO production" EXACT []
is_a: GO:0052263 ! induction by organism of defense-related nitric oxide production in other organism involved in symbiotic interaction
is_a: GO:0052347 ! positive regulation by symbiont of defense-related host nitric oxide production
is_a: GO:0052509 ! positive regulation by symbiont of host defense response
is_a: GO:0052559 ! induction by symbiont of host immune response

[Term]
id: GO:0052064
name: induction by symbiont of defense-related host reactive oxygen species production
namespace: biological_process
def: "The activation by an organism of the production of reactive oxygen species as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of defense-related host active oxygen species production" EXACT []
synonym: "activation by organism of defense-related host AOS production" EXACT []
synonym: "activation by organism of defense-related host metabolic burst" EXACT []
synonym: "activation by organism of defense-related host oxidative burst" EXACT []
synonym: "activation by organism of defense-related host reactive oxidative species production" EXACT []
synonym: "activation by organism of defense-related host reactive oxygen intermediate production" EXACT []
synonym: "activation by organism of defense-related host reactive oxygen species production" EXACT []
synonym: "activation by organism of defense-related host respiratory burst" EXACT []
synonym: "activation by organism of defense-related host ROI production" EXACT []
synonym: "activation by organism of defense-related host ROS production" EXACT []
synonym: "induction by organism of defense-related host active oxygen species production" EXACT []
synonym: "induction by organism of defense-related host AOS production" EXACT []
synonym: "induction by organism of defense-related host metabolic burst" EXACT []
synonym: "induction by organism of defense-related host oxidative burst" EXACT []
synonym: "induction by organism of defense-related host reactive oxidative species production" EXACT []
synonym: "induction by organism of defense-related host reactive oxygen intermediate production" EXACT []
synonym: "induction by organism of defense-related host respiratory burst" EXACT []
synonym: "induction by organism of defense-related host ROI production" EXACT []
synonym: "induction by organism of defense-related host ROS production" EXACT []
is_a: GO:0052264 ! induction by organism of defense-related reactive oxygen species production in other organism involved in symbiotic interaction
is_a: GO:0052369 ! positive regulation by symbiont of defense-related host reactive oxygen species production
is_a: GO:0052559 ! induction by symbiont of host immune response

[Term]
id: GO:0052065
name: positive regulation by organism of defense-related calcium ion flux in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of fluxes of calcium ions that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of defense-related calcium ion flux in other organism during symbiotic interaction" NARROW []
synonym: "positive regulation by organism of defense-related Ca2+ flux in other organism during symbiotic interaction" RELATED []
synonym: "positive regulation by organism of defense-related calcium ion flux in other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "stimulation by organism of defense-related calcium ion flux in other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of defense-related calcium ion flux in other organism during symbiotic interaction" RELATED []
synonym: "up-regulation by organism of defense-related calcium ion flux in other organism during symbiotic interaction" RELATED []
synonym: "upregulation by organism of defense-related calcium ion flux in other organism during symbiotic interaction" RELATED []
is_a: GO:0052301 ! modulation by organism of defense-related calcium ion flux in other organism involved in symbiotic interaction
is_a: GO:0052510 ! positive regulation by organism of defense response of other organism involved in symbiotic interaction

[Term]
id: GO:0052066
name: entry of symbiont into host cell by promotion of host phagocytosis
namespace: biological_process
def: "The invasion by an organism of a cell of its host organism by utilizing the host phagocytosis mechanism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "entry of organism into host cell by promotion of host phagocytosis" EXACT []
is_a: GO:0030260 ! entry into host cell
is_a: GO:0052191 ! positive regulation by symbiont of host phagocytosis
is_a: GO:0052370 ! entry of organism into cell of other organism by promotion of phagocytosis in other organism involved in symbiotic interaction

[Term]
id: GO:0052067
name: negative regulation by symbiont of entry into host cell via phagocytosis
namespace: biological_process
def: "Any process in which an organism stops or prevents itself undergoing phagocytosis into a cell in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "down regulation by symbiont of entry into host cell via phagocytosis" EXACT []
synonym: "down-regulation by symbiont of entry into host cell via phagocytosis" EXACT []
synonym: "downregulation by symbiont of entry into host cell via phagocytosis" EXACT []
synonym: "inhibition by symbiont of entry into host cell via phagocytosis" NARROW []
synonym: "negative regulation by organism of entry into host cell via host phagocytosis" EXACT []
is_a: GO:0044415 ! evasion or tolerance of host defenses
is_a: GO:0052374 ! negative regulation by symbiont of entry into host
is_a: GO:0052380 ! modulation by symbiont of entry into host via phagocytosis
is_a: GO:0052483 ! negative regulation by organism of entry into cell of other organism via phagocytosis involved in symbiotic interaction

[Term]
id: GO:0052068
name: negative regulation by symbiont of host jasmonic acid-mediated defense response
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the jasmonic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by symbiont of host jasmonic acid-mediated defense response" EXACT []
synonym: "down-regulation by symbiont of host jasmonic acid-mediated defense response" EXACT []
synonym: "downregulation by symbiont of host jasmonic acid-mediated defense response" EXACT []
synonym: "inhibition by symbiont of host jasmonic acid-mediated defense response" NARROW []
synonym: "suppression by organism of host JA-mediated defense response" EXACT []
is_a: GO:0052037 ! negative regulation by symbiont of host defense response
is_a: GO:0052088 ! modulation by symbiont of host jasmonic acid-mediated defense response
is_a: GO:0052266 ! negative regulation by organism of jasmonic acid-mediated defense response of other organism involved in symbiotic interaction
is_a: GO:0052562 ! negative regulation by symbiont of host immune response

[Term]
id: GO:0052069
name: negative regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of host jasmonic acid-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" EXACT []
synonym: "down-regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" EXACT []
synonym: "downregulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" EXACT []
synonym: "inhibition by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW []
synonym: "negative regulation by organism of defense-related host JA-mediated signal transduction pathway" EXACT []
is_a: GO:0052029 ! negative regulation by symbiont of host signal transduction pathway
is_a: GO:0052068 ! negative regulation by symbiont of host jasmonic acid-mediated defense response
is_a: GO:0052082 ! modulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway
is_a: GO:0052267 ! negative regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction

[Term]
id: GO:0052070
name: negative regulation by symbiont of defense-related host ethylene-mediated signal transduction pathway
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of host ethylene-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by symbiont of defense-related host ethylene-mediated signal transduction pathway" EXACT []
synonym: "down-regulation by symbiont of defense-related host ethylene-mediated signal transduction pathway" EXACT []
synonym: "downregulation by symbiont of defense-related host ethylene-mediated signal transduction pathway" EXACT []
synonym: "inhibition by symbiont of defense-related host ethylene-mediated signal transduction pathway" NARROW []
synonym: "suppression by organism of defense-related host ethylene-mediated signal transduction pathway" EXACT []
is_a: GO:0052005 ! negative regulation by symbiont of host ethylene-mediated defense response
is_a: GO:0052029 ! negative regulation by symbiont of host signal transduction pathway
is_a: GO:0052077 ! modulation by symbiont of defense-related host ethylene-mediated signal transduction pathway
is_a: GO:0052268 ! negative regulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism involved in symbiotic interaction

[Term]
id: GO:0052071
name: positive regulation by symbiont of defense-related host ethylene-mediated signal transduction pathway
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of host ethylene-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of defense-related host ethylene-mediated signal transduction pathway" NARROW []
synonym: "activation by symbiont of defense-related host ethylene-mediated signal transduction pathway" NARROW []
synonym: "induction by organism of defense-related host ethylene-mediated signal transduction pathway" NARROW []
synonym: "stimulation by symbiont of defense-related host ethylene-mediated signal transduction pathway" NARROW []
synonym: "up regulation by symbiont of defense-related host ethylene-mediated signal transduction pathway" EXACT []
synonym: "up-regulation by symbiont of defense-related host ethylene-mediated signal transduction pathway" EXACT []
synonym: "upregulation by organism of defense-related host ethylene-mediated signal transduction pathway" NARROW []
synonym: "upregulation by symbiont of defense-related host ethylene-mediated signal transduction pathway" EXACT []
is_a: GO:0052028 ! positive regulation by symbiont of host signal transduction pathway
is_a: GO:0052076 ! positive regulation by symbiont of host ethylene-mediated defense response
is_a: GO:0052077 ! modulation by symbiont of defense-related host ethylene-mediated signal transduction pathway
is_a: GO:0052269 ! positive regulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism involved in symbiotic interaction

[Term]
id: GO:0052072
name: positive regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of host salicylic acid-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of defense-related host SA-mediated signal transduction pathway" NARROW []
synonym: "activation by organism of defense-related host salicylic acid-mediated signal transduction pathway" NARROW []
synonym: "activation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" NARROW []
synonym: "induction by organism of defense-related host SA-mediated signal transduction pathway" NARROW []
synonym: "induction by organism of defense-related host salicylic acid-mediated signal transduction pathway" NARROW []
synonym: "positive regulation by organism of defense-related host SA-mediated signal transduction pathway" NARROW []
synonym: "stimulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" NARROW []
synonym: "up regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" EXACT []
synonym: "up-regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" EXACT []
synonym: "upregulation by organism of defense-related host SA-mediated signal transduction pathway" NARROW []
synonym: "upregulation by organism of defense-related host salicylic acid-mediated signal transduction pathway" NARROW []
synonym: "upregulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" EXACT []
is_a: GO:0052028 ! positive regulation by symbiont of host signal transduction pathway
is_a: GO:0052074 ! positive regulation by symbiont of host salicylic acid-mediated defense response
is_a: GO:0052081 ! modulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway
is_a: GO:0052270 ! positive regulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction

[Term]
id: GO:0052073
name: positive regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of host jasmonic acid-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW []
synonym: "activation by organism of defense-related host SA-mediated signal transduction pathway" NARROW []
synonym: "activation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW []
synonym: "induction by organism of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW []
synonym: "induction by organism of defense-related host SA-mediated signal transduction pathway" NARROW []
synonym: "positive regulation by organism of defense-related host SA-mediated signal transduction pathway" EXACT []
synonym: "stimulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW []
synonym: "up regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" EXACT []
synonym: "up-regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" EXACT []
synonym: "upregulation by organism of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW []
synonym: "upregulation by organism of defense-related host SA-mediated signal transduction pathway" NARROW []
synonym: "upregulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" EXACT []
is_a: GO:0052028 ! positive regulation by symbiont of host signal transduction pathway
is_a: GO:0052075 ! positive regulation by symbiont of host jasmonic acid-mediated defense response
is_a: GO:0052082 ! modulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway
is_a: GO:0052271 ! positive regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction

[Term]
id: GO:0052074
name: positive regulation by symbiont of host salicylic acid-mediated defense response
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the salicylic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by symbiont of host salicylic acid-mediated defense response" NARROW []
synonym: "induction by organism of host SA-mediated defense response" NARROW []
synonym: "induction by organism of host salicylic acid-mediated defense response" NARROW []
synonym: "positive regulation by organism of host SA-mediated defense response" EXACT []
synonym: "stimulation by symbiont of host salicylic acid-mediated defense response" NARROW []
synonym: "up regulation by symbiont of host salicylic acid-mediated defense response" EXACT []
synonym: "up-regulation by symbiont of host salicylic acid-mediated defense response" EXACT []
synonym: "upregulation by symbiont of host salicylic acid-mediated defense response" EXACT []
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0052089 ! modulation by symbiont of host salicylic acid-mediated defense response
is_a: GO:0052272 ! positive regulation by organism of salicylic acid-mediated defense response of other organism involved in symbiotic interaction
is_a: GO:0052509 ! positive regulation by symbiont of host defense response
is_a: GO:1901672 ! positive regulation of systemic acquired resistance
relationship: positively_regulates GO:0009862 ! systemic acquired resistance, salicylic acid mediated signaling pathway

[Term]
id: GO:0052075
name: positive regulation by symbiont of host jasmonic acid-mediated defense response
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the jasmonic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by symbiont of host jasmonic acid-mediated defense response" NARROW []
synonym: "induction by organism of host JA-mediated defense response" NARROW []
synonym: "induction by organism of host jasmonic acid-mediated defense response" NARROW []
synonym: "positive regulation by organism of host JA-mediated defense response" EXACT []
synonym: "stimulation by symbiont of host jasmonic acid-mediated defense response" NARROW []
synonym: "up regulation by symbiont of host jasmonic acid-mediated defense response" EXACT []
synonym: "up-regulation by symbiont of host jasmonic acid-mediated defense response" EXACT []
synonym: "upregulation by symbiont of host jasmonic acid-mediated defense response" EXACT []
is_a: GO:0052088 ! modulation by symbiont of host jasmonic acid-mediated defense response
is_a: GO:0052273 ! positive regulation by organism of jasmonic acid-mediated defense response of other organism involved in symbiotic interaction
is_a: GO:0052509 ! positive regulation by symbiont of host defense response
is_a: GO:0052556 ! positive regulation by symbiont of host immune response

[Term]
id: GO:0052076
name: positive regulation by symbiont of host ethylene-mediated defense response
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the ethylene-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of host ethylene-mediated defense response" NARROW []
synonym: "activation by symbiont of host ethylene-mediated defense response" NARROW []
synonym: "induction by organism of host ethylene-mediated defense response" NARROW []
synonym: "stimulation by symbiont of host ethylene-mediated defense response" NARROW []
synonym: "up regulation by symbiont of host ethylene-mediated defense response" EXACT []
synonym: "up-regulation by symbiont of host ethylene-mediated defense response" EXACT []
synonym: "upregulation by organism of host ethylene-mediated defense response" NARROW []
synonym: "upregulation by symbiont of host ethylene-mediated defense response" EXACT []
is_a: GO:0052084 ! modulation by symbiont of host ethylene-mediated defense response
is_a: GO:0052274 ! positive regulation by organism of ethylene-mediated defense response of other organism involved in symbiotic interaction
is_a: GO:0052509 ! positive regulation by symbiont of host defense response

[Term]
id: GO:0052077
name: modulation by symbiont of defense-related host ethylene-mediated signal transduction pathway
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of host ethylene-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway
is_a: GO:0052031 ! modulation by symbiont of host defense response
is_a: GO:0052441 ! modulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism involved in symbiotic interaction

[Term]
id: GO:0052078
name: negative regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of host MAP kinase-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" EXACT []
synonym: "down-regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" EXACT []
synonym: "downregulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" EXACT []
synonym: "inhibition by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" NARROW []
synonym: "negative regulation by organism of defense-related host MAPK-mediated signal transduction pathway" EXACT []
synonym: "negative regulation by organism of defense-related host mitogen-activated protein kinase-mediated signal transduction pathway" EXACT []
synonym: "suppression by organism of defense-related host MAP kinase-mediated signal transduction pathway" EXACT []
is_a: GO:0052037 ! negative regulation by symbiont of host defense response
is_a: GO:0052080 ! modulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway
is_a: GO:0052275 ! negative regulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism involved in symbiotic interaction
is_a: GO:0075132 ! negative regulation by symbiont of host protein kinase-mediated signal transduction

[Term]
id: GO:0052079
name: positive regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of host MAP kinase-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of defense-related host MAP kinase-mediated signal transduction pathway" NARROW []
synonym: "activation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" NARROW []
synonym: "induction by organism of defense-related host MAP kinase-mediated signal transduction pathway" NARROW []
synonym: "positive regulation by organism of defense-related host MAPK-mediated signal transduction pathway" EXACT []
synonym: "positive regulation by organism of defense-related host mitogen-activated protein kinase-mediated signal transduction pathway" EXACT []
synonym: "stimulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" NARROW []
synonym: "up regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" EXACT []
synonym: "up-regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" EXACT []
synonym: "upregulation by organism of defense-related host MAP kinase-mediated signal transduction pathway" NARROW []
synonym: "upregulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" EXACT []
is_a: GO:0052080 ! modulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway
is_a: GO:0052276 ! positive regulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism involved in symbiotic interaction
is_a: GO:0052509 ! positive regulation by symbiont of host defense response
is_a: GO:0075131 ! positive regulation by symbiont of host protein kinase-mediated signal transduction

[Term]
id: GO:0052080
name: modulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of host MAP kinase-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation of defense-related host MAPK-mediated signal transduction pathway by organism" EXACT []
synonym: "modulation of defense-related host mitogen activated protein kinase-mediated signal transduction pathway by organism" EXACT []
is_a: GO:0052031 ! modulation by symbiont of host defense response
is_a: GO:0052277 ! modulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism involved in symbiotic interaction
is_a: GO:0075130 ! modulation by symbiont of host protein kinase-mediated signal transduction

[Term]
id: GO:0052081
name: modulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of host salicylic acid-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation of defense-related host SA-mediated signal transduction pathway by organism" EXACT []
is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway
is_a: GO:0052031 ! modulation by symbiont of host defense response
is_a: GO:0052445 ! modulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction

[Term]
id: GO:0052082
name: modulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of host jasmonic acid-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation of defense-related host JA-mediated signal transduction pathway by organism" EXACT []
is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway
is_a: GO:0052031 ! modulation by symbiont of host defense response
is_a: GO:0052443 ! modulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction

[Term]
id: GO:0052083
name: negative regulation by symbiont of host cell-mediated immune response
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by symbiont of host cell-mediated immune response" EXACT []
synonym: "down-regulation by symbiont of host cell-mediated immune response" EXACT []
synonym: "downregulation by symbiont of host cell-mediated immune response" EXACT []
synonym: "inhibition by symbiont of host cell-mediated immune response" NARROW []
synonym: "negative regulation by organism of host cell-based immune response" EXACT []
is_a: GO:0052155 ! modulation by symbiont of host cell-mediated immune response
is_a: GO:0052278 ! negative regulation by organism of cell-mediated immune response of other organism involved in symbiotic interaction
is_a: GO:0052562 ! negative regulation by symbiont of host immune response

[Term]
id: GO:0052084
name: modulation by symbiont of host ethylene-mediated defense response
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of the ethylene-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052031 ! modulation by symbiont of host defense response
is_a: GO:0052279 ! modulation by organism of ethylene-mediated defense response of other organism involved in symbiotic interaction

[Term]
id: GO:0052085
name: negative regulation by symbiont of host T-cell mediated immune response
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the T-cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by symbiont of host T-cell mediated immune response" EXACT []
synonym: "down-regulation by symbiont of host T-cell mediated immune response" EXACT []
synonym: "downregulation by symbiont of host T-cell mediated immune response" EXACT []
synonym: "inhibition by symbiont of host T-cell mediated immune response" NARROW []
is_a: GO:0052083 ! negative regulation by symbiont of host cell-mediated immune response
is_a: GO:0052156 ! modulation by symbiont of host T-cell mediated immune response
is_a: GO:0052280 ! negative regulation by organism of T-cell mediated immune response of other organism involved in symbiotic interaction

[Term]
id: GO:0052086
name: negative regulation by symbiont of host B-cell mediated immune response
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the B-cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by symbiont of host B-cell mediated immune response" EXACT []
synonym: "down-regulation by symbiont of host B-cell mediated immune response" EXACT []
synonym: "downregulation by symbiont of host B-cell mediated immune response" EXACT []
synonym: "inhibition by symbiont of host B-cell mediated immune response" NARROW []
is_a: GO:0052083 ! negative regulation by symbiont of host cell-mediated immune response
is_a: GO:0052154 ! modulation by symbiont of host B-cell mediated immune response
is_a: GO:0052281 ! negative regulation by organism of B-cell mediated immune response of other organism involved in symbiotic interaction

[Term]
id: GO:0052087
name: negative regulation by symbiont of defense-related host callose deposition
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of callose deposition performed by the host as part of its defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by symbiont of defense-related host callose deposition" EXACT []
synonym: "down-regulation by symbiont of defense-related host callose deposition" EXACT []
synonym: "downregulation by symbiont of defense-related host callose deposition" EXACT []
synonym: "inhibition by symbiont of defense-related host callose deposition" NARROW []
synonym: "suppression by organism of defense-related host callose deposition" EXACT []
is_a: GO:0052037 ! negative regulation by symbiont of host defense response
is_a: GO:0052090 ! modulation by symbiont of defense-related host callose deposition
is_a: GO:0052282 ! negative regulation by organism of defense-related callose deposition in other organism involved in symbiotic interaction

[Term]
id: GO:0052088
name: modulation by symbiont of host jasmonic acid-mediated defense response
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of the jasmonic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of host JA-mediated defense response" EXACT []
is_a: GO:0052283 ! modulation by organism of jasmonic acid-mediated defense response of other organism involved in symbiotic interaction
is_a: GO:0052553 ! modulation by symbiont of host immune response

[Term]
id: GO:0052089
name: modulation by symbiont of host salicylic acid-mediated defense response
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of the salicylic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of host SA-mediated defense response" EXACT []
is_a: GO:0010112 ! regulation of systemic acquired resistance
is_a: GO:0052031 ! modulation by symbiont of host defense response
is_a: GO:0052284 ! modulation by organism of salicylic acid-mediated defense response of other organism involved in symbiotic interaction
is_a: GO:2000031 ! regulation of salicylic acid mediated signaling pathway
relationship: regulates GO:0009862 ! systemic acquired resistance, salicylic acid mediated signaling pathway

[Term]
id: GO:0052090
name: modulation by symbiont of defense-related host callose deposition
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of callose deposition by the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052031 ! modulation by symbiont of host defense response
is_a: GO:0052285 ! modulation by organism of defense-related callose deposition of other organism involved in symbiotic interaction

[Term]
id: GO:0052091
name: modulation by symbiont of nutrient release from host
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of the release of nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0044003 ! modification by symbiont of host morphology or physiology
is_a: GO:0052313 ! modulation of nutrient release from other organism involved in symbiotic interaction
relationship: part_of GO:0044002 ! acquisition of nutrients from host

[Term]
id: GO:0052092
name: positive regulation by symbiont of nutrient release from host
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the release of nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by symbiont of nutrient release from host" NARROW []
synonym: "promotion of nutrient release from host" EXACT []
synonym: "stimulation by symbiont of nutrient release from host" NARROW []
synonym: "up regulation by symbiont of nutrient release from host" EXACT []
synonym: "up-regulation by symbiont of nutrient release from host" EXACT []
synonym: "upregulation by symbiont of nutrient release from host" EXACT []
is_a: GO:0052091 ! modulation by symbiont of nutrient release from host
is_a: GO:0052520 ! positive regulation by organism of nutrient release from other organism involved in symbiotic interaction

[Term]
id: GO:0052093
name: formation of specialized structure for nutrient acquisition from host
namespace: biological_process
def: "The assembly by an organism of a cellular component or anatomical structure for the purpose of obtaining nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "formation by organism of specialized structure for nutrient acquisition from host" EXACT []
synonym: "formation by symbiont of specialized structure for nutrient acquisition from host" EXACT []
is_a: GO:0044115 ! development of symbiont involved in interaction with host
is_a: GO:0052095 ! formation of specialized structure for nutrient acquisition from other organism involved in symbiotic interaction
relationship: part_of GO:0044002 ! acquisition of nutrients from host

[Term]
id: GO:0052094
name: formation by symbiont of haustorium for nutrient acquisition from host
namespace: biological_process
def: "The assembly by an organism of a haustorium, a projection from a cell or tissue that penetrates the host's tissues for the purpose of obtaining nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, http://www.onelook.com]
synonym: "formation by organism of haustoria for nutrient acquisition from host" EXACT []
synonym: "formation by organism of haustorium for nutrient acquisition from host" EXACT []
is_a: GO:0044118 ! development of symbiont in host cell
is_a: GO:0052093 ! formation of specialized structure for nutrient acquisition from host

[Term]
id: GO:0052095
name: formation of specialized structure for nutrient acquisition from other organism involved in symbiotic interaction
namespace: biological_process
def: "The assembly by an organism of a cellular component or anatomical structure for the purpose of obtaining nutrients from a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "formation of specialized structure for nutrient acquisition from other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0044111 ! development involved in symbiotic interaction
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0051816 ! acquisition of nutrients from other organism during symbiotic interaction

[Term]
id: GO:0052096
name: formation by symbiont of syncytium involving giant cell for nutrient acquisition from host
namespace: biological_process
def: "The assembly by an organism of a syncytium, a nematode-induced multi-nucleate and physiologically active aggregation of fused root cells which exclusively provides the nematode with nourishment during its sedentary life, for the purpose of obtaining nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "formation by organism of syncytium involving giant cell for nutrient acquisition from host" EXACT []
is_a: GO:0052093 ! formation of specialized structure for nutrient acquisition from host

[Term]
id: GO:0052097
name: interspecies quorum sensing
namespace: biological_process
def: "The process in which a community of single-celled organisms of different species monitors population density by detecting the concentration of small diffusible signal molecules." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0009372 ! quorum sensing
is_a: GO:0044419 ! interspecies interaction between organisms

[Term]
id: GO:0052098
name: formation by host of specialized structure for nutrient acquisition from symbiont
namespace: biological_process
def: "The assembly by an organism of a cellular component or anatomical structure for the purpose of obtaining nutrients from a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0052095 ! formation of specialized structure for nutrient acquisition from other organism involved in symbiotic interaction
relationship: part_of GO:0051850 ! acquisition of nutrients from symbiont

[Term]
id: GO:0052099
name: acquisition by symbiont of nutrients from host via siderophores
namespace: biological_process
def: "The process that begins with the production and formation of siderophores in an organism that are required for the acquisition and utilization of nutrients from its host organism, and the ends with the acquirement of the nutrients. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mah]
synonym: "acquisition by organism of nutrients from host via siderophores" EXACT []
is_a: GO:0044002 ! acquisition of nutrients from host

[Term]
id: GO:0052100
name: intraspecies quorum sensing
namespace: biological_process
def: "The process in which single-celled organisms of the same species monitor population density by detecting the concentration of small, diffusible signal molecules." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0009372 ! quorum sensing
is_a: GO:0051703 ! intraspecies interaction between organisms

[Term]
id: GO:0052101
name: induction by symbiont of host resistance gene-dependent defense response
namespace: biological_process
def: "The activation by an organism of the resistance gene-dependent defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of defense response in host by specific elicitors" EXACT []
synonym: "activation by organism of host gene-for-gene resistance" EXACT []
synonym: "activation by organism of host resistance gene-dependent defense response" EXACT []
synonym: "activation by organism of pathogen-race/host plant cultivar-specific resistance in host" EXACT []
synonym: "induction by organism of defense response in host by specific elicitors" EXACT []
synonym: "induction by organism of host gene-for-gene resistance" EXACT []
synonym: "induction by organism of pathogen-race/host plant cultivar-specific resistance in host" EXACT []
is_a: GO:0052286 ! induction by organism of resistance gene-dependent defense response of other organism involved in symbiotic interaction
is_a: GO:0052527 ! positive regulation by symbiont of host resistance gene-dependent defense response
is_a: GO:0052559 ! induction by symbiont of host immune response

[Term]
id: GO:0052102
name: positive regulation by symbiont of defense-related host calcium-dependent protein kinase pathway
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the host calcium-dependent protein kinase pathway during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by symbiont of defense-related host calcium-dependent protein kinase pathway" NARROW []
synonym: "positive regulation of defense-related host CDPK pathway by organism" EXACT []
synonym: "stimulation by symbiont of defense-related host calcium-dependent protein kinase pathway" NARROW []
synonym: "up regulation by symbiont of defense-related host calcium-dependent protein kinase pathway" EXACT []
synonym: "up-regulation by symbiont of defense-related host calcium-dependent protein kinase pathway" EXACT []
synonym: "upregulation by symbiont of defense-related host calcium-dependent protein kinase pathway" EXACT []
is_a: GO:0052168 ! modulation by symbiont of defense-related host calcium-dependent protein kinase pathway
is_a: GO:0052287 ! positive regulation by organism of defense-related calcium-dependent protein kinase pathway in other organism involved in symbiotic interaction
is_a: GO:0052509 ! positive regulation by symbiont of host defense response

[Term]
id: GO:0052103
name: induction by symbiont of host induced systemic resistance
namespace: biological_process
def: "Any process in which an organism activates induced systemic resistance in the host; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of induced systemic resistance in host" EXACT []
synonym: "activation by organism of ISR in host" EXACT []
synonym: "induction by organism of ISR in host" EXACT []
synonym: "induction by symbiont of induced systemic resistance in host" EXACT []
is_a: GO:0052288 ! induction by organism of induced systemic resistance in other organism involved in symbiotic interaction
is_a: GO:0052390 ! induction by symbiont of host innate immune response
is_a: GO:0052533 ! positive regulation by symbiont of host induced systemic resistance

[Term]
id: GO:0052104
name: induction by symbiont of host systemic acquired resistance
namespace: biological_process
def: "Any process in which an organism activates systemic acquired resistance in the host organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of SAR in host" EXACT []
synonym: "activation by organism of systemic acquired resistance in host" EXACT []
synonym: "induction by organism of SAR in host" EXACT []
synonym: "induction by symbiont of systemic acquired resistance in host" EXACT []
is_a: GO:0052289 ! induction by organism of systemic acquired resistance in other organism involved in symbiotic interaction
is_a: GO:0052390 ! induction by symbiont of host innate immune response
is_a: GO:0052537 ! positive regulation by symbiont of host systemic acquired resistance

[Term]
id: GO:0052105
name: induction by symbiont of defense-related host cell wall thickening
namespace: biological_process
def: "The activation by an organism of host processes resulting in the thickening of its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of defense-related host cell wall thickening" EXACT []
synonym: "activation by organism of host defensive cell wall thickening" EXACT []
synonym: "induction by organism of host defensive cell wall thickening" EXACT []
is_a: GO:0044416 ! induction by symbiont of host defense response
is_a: GO:0052290 ! induction by organism of defense-related cell wall thickening in other organism involved in symbiotic interaction
is_a: GO:0052539 ! positive regulation by symbiont of defense-related host cell wall thickening

[Term]
id: GO:0052106
name: quorum sensing involved in interaction with host
namespace: biological_process
def: "The process in which a community of single-celled organisms living in intimate contact with a host organism monitors population density by detecting the concentration of small diffusible signal molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "quorum sensing during interaction with host" RELATED [GOC:tb]
is_a: GO:0052097 ! interspecies quorum sensing
intersection_of: GO:0009372 ! quorum sensing
intersection_of: part_of GO:0051701 ! interaction with host
relationship: part_of GO:0051701 ! interaction with host

[Term]
id: GO:0052107
name: positive regulation by symbiont of defense-related host callose deposition
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of callose deposition by the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by symbiont of defense-related host callose deposition" NARROW []
synonym: "induction by organism of defense-related host callose deposition" NARROW []
synonym: "induction by organism of defense-related papilla formation in host" NARROW []
synonym: "positive regulation by organism of defense-related papilla formation in host" EXACT []
synonym: "stimulation by symbiont of defense-related host callose deposition" NARROW []
synonym: "up regulation by symbiont of defense-related host callose deposition" EXACT []
synonym: "up-regulation by symbiont of defense-related host callose deposition" EXACT []
synonym: "upregulation by symbiont of defense-related host callose deposition" EXACT []
is_a: GO:0052090 ! modulation by symbiont of defense-related host callose deposition
is_a: GO:0052291 ! positive regulation by organism of defense-related callose deposition in other organism involved in symbiotic interaction
is_a: GO:0052509 ! positive regulation by symbiont of host defense response

[Term]
id: GO:0052108
name: obsolete growth or development of symbiont during interaction with host
namespace: biological_process
def: "OBSOLETE. The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'growth of symbiont during interaction with host ; GO:0044116' and 'development of symbiont during interaction with host ; GO:0044115'.
subset: gosubset_prok
synonym: "growth or development of organism during interaction with host" EXACT []
synonym: "growth or development of organism in response to host" EXACT []
synonym: "growth or development of symbiont during interaction with host" EXACT []
is_obsolete: true
consider: GO:0044115
consider: GO:0044116

[Term]
id: GO:0052109
name: positive regulation by symbiont of defense-related host cell wall callose deposition
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the deposition of callose by the host in its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by symbiont of defense-related host cell wall callose deposition" NARROW []
synonym: "induction by organism of defense-related host cell wall callose deposition" NARROW []
synonym: "positive regulation by organism of defense-related host cell wall callose deposition" EXACT []
synonym: "stimulation by symbiont of defense-related host cell wall callose deposition" NARROW []
synonym: "up regulation by symbiont of defense-related host cell wall callose deposition" EXACT []
synonym: "up-regulation by symbiont of defense-related host cell wall callose deposition" EXACT []
synonym: "upregulation by symbiont of defense-related host cell wall callose deposition" EXACT []
is_a: GO:0052107 ! positive regulation by symbiont of defense-related host callose deposition
is_a: GO:0052189 ! modulation by symbiont of defense-related host cell wall callose deposition
is_a: GO:0052292 ! positive regulation by organism of defense-related cell wall callose deposition in other organism involved in symbiotic interaction
is_a: GO:0052539 ! positive regulation by symbiont of defense-related host cell wall thickening

[Term]
id: GO:0052110
name: occlusion by symbiont of host vascular system
namespace: biological_process
def: "The process in which an organism reduces the flow of fluid within its host's vascular system, the vessels and tissue that carry or circulate fluids, such as blood, lymph or sap, through the body of an animal or plant. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, http://www.thefreedictionary.com]
subset: gosubset_prok
is_a: GO:0052111 ! modification by symbiont of host structure
is_a: GO:0052495 ! occlusion by organism of vascular system in other organism involved in symbiotic interaction

[Term]
id: GO:0052111
name: modification by symbiont of host structure
namespace: biological_process
def: "The process in which an organism effects a change in an anatomical part or cellular component of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0044003 ! modification by symbiont of host morphology or physiology
is_a: GO:0052185 ! modification of structure of other organism involved in symbiotic interaction

[Term]
id: GO:0052112
name: occlusion by symbiont of host xylem
namespace: biological_process
def: "The process in which an organism reduces the flow of fluid within the host xylem, the tissue in plants that carries water and nutrients up from the roots to the shoot and leaves. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052110 ! occlusion by symbiont of host vascular system
is_a: GO:0052497 ! occlusion by organism of xylem in other organism involved in symbiotic interaction

[Term]
id: GO:0052113
name: obsolete adaptation to host osmotic environment
namespace: biological_process
def: "OBSOLETE. The responsive adjustment of an organism to the osmotic conditions in or around its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was made obsolete because adaptation was not deemed to be a valid biological process.
subset: gosubset_prok
synonym: "adaptation to host osmotic environment" EXACT []
synonym: "osmotic tolerance to host environment" EXACT []
is_obsolete: true

[Term]
id: GO:0052114
name: obsolete adaptation to host pH environment
namespace: biological_process
def: "OBSOLETE. The responsive adjustment of an organism to the pH conditions in or around its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was made obsolete because adaptation was not deemed to be a valid biological process.
subset: gosubset_prok
synonym: "adaptation to host pH environment" EXACT []
synonym: "pH tolerance to host environment" EXACT []
is_obsolete: true

[Term]
id: GO:0052115
name: energy taxis in host environment
namespace: biological_process
def: "The directed movement of a motile cell or organism in the environment of its host organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "energy taxis in response to host environment" EXACT []
is_a: GO:0052126 ! movement in host environment
is_a: GO:0052215 ! energy taxis in environment of other organism involved in symbiotic interaction

[Term]
id: GO:0052116
name: chemotaxis in host environment
namespace: biological_process
def: "The directed movement of a motile cell or organism in response to a specific chemical concentration gradient on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "chemotaxis in response to host environment" EXACT []
is_a: GO:0052126 ! movement in host environment
is_a: GO:0052216 ! chemotaxis in environment of other organism involved in symbiotic interaction

[Term]
id: GO:0052117
name: aerotaxis in host environment
namespace: biological_process
def: "The movement of a motile cell or organism in response to environmental oxygen on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "aerotaxis in response to host environment" EXACT []
is_a: GO:0052115 ! energy taxis in host environment
is_a: GO:0052116 ! chemotaxis in host environment
is_a: GO:0052217 ! aerotaxis in environment of other organism involved in symbiotic interaction

[Term]
id: GO:0052118
name: positive energy taxis in host environment
namespace: biological_process
def: "The directed movement of a motile cell or organism on, within or near its host organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "positive energy taxis in response to host environment" EXACT []
is_a: GO:0052115 ! energy taxis in host environment
is_a: GO:0052218 ! positive energy taxis in environment of other organism involved in symbiotic interaction

[Term]
id: GO:0052119
name: negative energy taxis in host environment
namespace: biological_process
def: "The directed movement of a motile cell or organism on, within or near its host organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "negative energy taxis in response to host environment" EXACT []
is_a: GO:0052115 ! energy taxis in host environment
is_a: GO:0052219 ! negative energy taxis in environment of other organism involved in symbiotic interaction

[Term]
id: GO:0052120
name: positive aerotaxis in host environment
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "positive aerotaxis in response to host environment" EXACT []
is_a: GO:0052117 ! aerotaxis in host environment
is_a: GO:0052118 ! positive energy taxis in host environment
is_a: GO:0052121 ! positive chemotaxis in host environment
is_a: GO:0052220 ! positive aerotaxis in environment of other organism involved in symbiotic interaction

[Term]
id: GO:0052121
name: positive chemotaxis in host environment
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a higher concentration of a chemical on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "positive chemotaxis in response to host environment" EXACT []
is_a: GO:0052116 ! chemotaxis in host environment
is_a: GO:0052221 ! positive chemotaxis in environment of other organism involved in symbiotic interaction

[Term]
id: GO:0052122
name: negative aerotaxis in host environment
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "negative aerotaxis in response to host environment" EXACT []
is_a: GO:0052117 ! aerotaxis in host environment
is_a: GO:0052119 ! negative energy taxis in host environment
is_a: GO:0052123 ! negative chemotaxis in host environment
is_a: GO:0052222 ! negative aerotaxis in environment of other organism involved in symbiotic interaction

[Term]
id: GO:0052123
name: negative chemotaxis in host environment
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a lower concentration of a specific chemical on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "negative chemotaxis in response to host environment" EXACT []
is_a: GO:0052116 ! chemotaxis in host environment
is_a: GO:0052223 ! negative chemotaxis in environment of other organism involved in symbiotic interaction

[Term]
id: GO:0052124
name: energy taxis within host
namespace: biological_process
def: "The directed movement of a motile cell or organism within its host organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0044000 ! movement in host
is_a: GO:0052115 ! energy taxis in host environment
is_a: GO:0052224 ! energy taxis in other organism involved in symbiotic interaction

[Term]
id: GO:0052125
name: energy taxis on or near host
namespace: biological_process
def: "The directed movement of a motile cell or organism on or near its host organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052115 ! energy taxis in host environment
is_a: GO:0052127 ! movement on or near host
is_a: GO:0052225 ! energy taxis on or near other organism involved in symbiotic interaction

[Term]
id: GO:0052126
name: movement in host environment
namespace: biological_process
def: "The directed movement of an organism or motile cell on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "movement in response to host" EXACT []
is_a: GO:0051701 ! interaction with host
is_a: GO:0052192 ! movement in environment of other organism involved in symbiotic interaction

[Term]
id: GO:0052127
name: movement on or near host
namespace: biological_process
def: "The directed movement of an organism or motile cell on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052126 ! movement in host environment
is_a: GO:0052195 ! movement on or near other organism involved in symbiotic interaction

[Term]
id: GO:0052128
name: positive energy taxis
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates." [GOC:mtg_pamgo_17jul06]
is_a: GO:0009453 ! energy taxis

[Term]
id: GO:0052129
name: negative energy taxis
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates." [GOC:mtg_pamgo_17jul06]
is_a: GO:0009453 ! energy taxis

[Term]
id: GO:0052130
name: negative aerotaxis
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen." [GOC:dph, GOC:mtg_pamgo_17jul06]
is_a: GO:0009454 ! aerotaxis
is_a: GO:0050919 ! negative chemotaxis
is_a: GO:0052129 ! negative energy taxis

[Term]
id: GO:0052131
name: positive aerotaxis
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen." [GOC:dph, GOC:mtg_pamgo_17jul06]
is_a: GO:0009454 ! aerotaxis
is_a: GO:0050918 ! positive chemotaxis
is_a: GO:0052128 ! positive energy taxis

[Term]
id: GO:0052132
name: positive aerotaxis on or near host
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052120 ! positive aerotaxis in host environment
is_a: GO:0052138 ! aerotaxis on or near host
is_a: GO:0052141 ! positive chemotaxis on or near host
is_a: GO:0052146 ! positive energy taxis on or near host
is_a: GO:0052232 ! positive aerotaxis on or near other organism involved in symbiotic interaction

[Term]
id: GO:0052133
name: positive aerotaxis in host
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "positive aerotaxis within host" EXACT []
is_a: GO:0052120 ! positive aerotaxis in host environment
is_a: GO:0052137 ! aerotaxis in host
is_a: GO:0052140 ! positive chemotaxis in host
is_a: GO:0052147 ! positive energy taxis in host
is_a: GO:0052233 ! positive aerotaxis in other organism involved in symbiotic interaction

[Term]
id: GO:0052134
name: negative aerotaxis on or near host
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052122 ! negative aerotaxis in host environment
is_a: GO:0052136 ! negative chemotaxis on or near host
is_a: GO:0052138 ! aerotaxis on or near host
is_a: GO:0052145 ! negative energy taxis on or near host
is_a: GO:0052234 ! negative aerotaxis on or near other organism involved in symbiotic interaction

[Term]
id: GO:0052135
name: negative aerotaxis in host
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "negative aerotaxis within host" EXACT []
is_a: GO:0052122 ! negative aerotaxis in host environment
is_a: GO:0052137 ! aerotaxis in host
is_a: GO:0052139 ! negative chemotaxis in host
is_a: GO:0052144 ! negative energy taxis in host
is_a: GO:0052235 ! negative aerotaxis in other organism involved in symbiotic interaction

[Term]
id: GO:0052136
name: negative chemotaxis on or near host
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a lower concentration of a specific chemical on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052123 ! negative chemotaxis in host environment
is_a: GO:0052143 ! chemotaxis on or near host involved in symbiotic interaction
is_a: GO:0052236 ! negative chemotaxis on or near other organism involved in symbiotic interaction

[Term]
id: GO:0052137
name: aerotaxis in host
namespace: biological_process
def: "The movement of a motile cell or organism in response to environmental oxygen within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "aerotaxis within host" EXACT []
is_a: GO:0052117 ! aerotaxis in host environment
is_a: GO:0052124 ! energy taxis within host
is_a: GO:0052142 ! chemotaxis within host
is_a: GO:0052237 ! aerotaxis in other organism involved in symbiotic interaction

[Term]
id: GO:0052138
name: aerotaxis on or near host
namespace: biological_process
def: "The movement of a motile cell or organism in response to environmental oxygen on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052117 ! aerotaxis in host environment
is_a: GO:0052125 ! energy taxis on or near host
is_a: GO:0052143 ! chemotaxis on or near host involved in symbiotic interaction
is_a: GO:0052238 ! aerotaxis on or near other organism involved in symbiotic interaction

[Term]
id: GO:0052139
name: negative chemotaxis in host
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a lower concentration of a specific chemical within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "negative chemotaxis within host" EXACT []
is_a: GO:0052123 ! negative chemotaxis in host environment
is_a: GO:0052142 ! chemotaxis within host
is_a: GO:0052239 ! negative chemotaxis in other organism involved in symbiotic interaction

[Term]
id: GO:0052140
name: positive chemotaxis in host
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a higher concentration of a specific chemical within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "positive chemotaxis within host" EXACT []
is_a: GO:0052121 ! positive chemotaxis in host environment
is_a: GO:0052142 ! chemotaxis within host
is_a: GO:0052240 ! positive chemotaxis in other organism involved in symbiotic interaction

[Term]
id: GO:0052141
name: positive chemotaxis on or near host
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a higher concentration of a specific chemical on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052121 ! positive chemotaxis in host environment
is_a: GO:0052143 ! chemotaxis on or near host involved in symbiotic interaction
is_a: GO:0052241 ! positive chemotaxis on or near other organism involved in symbiotic interaction

[Term]
id: GO:0052142
name: chemotaxis within host
namespace: biological_process
def: "The directed movement of a motile cell or organism in response to a specific chemical concentration gradient within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0044000 ! movement in host
is_a: GO:0052116 ! chemotaxis in host environment
is_a: GO:0052242 ! chemotaxis in other organism involved in symbiotic interaction

[Term]
id: GO:0052143
name: chemotaxis on or near host involved in symbiotic interaction
namespace: biological_process
def: "The directed movement of a motile cell or organism in response to a specific chemical concentration gradient on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "chemotaxis on or near host during symbiotic interaction" RELATED [GOC:tb]
is_a: GO:0052116 ! chemotaxis in host environment
is_a: GO:0052127 ! movement on or near host
is_a: GO:0052243 ! chemotaxis on or near other organism involved in symbiotic interaction

[Term]
id: GO:0052144
name: negative energy taxis in host
namespace: biological_process
def: "The directed movement of a motile cell or organism within its host organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "negative energy taxis within host" EXACT []
is_a: GO:0052119 ! negative energy taxis in host environment
is_a: GO:0052124 ! energy taxis within host
is_a: GO:0052244 ! negative energy taxis in other organism involved in symbiotic interaction

[Term]
id: GO:0052145
name: negative energy taxis on or near host
namespace: biological_process
def: "The directed movement of a motile cell or organism on or near its host organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052119 ! negative energy taxis in host environment
is_a: GO:0052125 ! energy taxis on or near host
is_a: GO:0052245 ! negative energy taxis on or near other organism involved in symbiotic interaction

[Term]
id: GO:0052146
name: positive energy taxis on or near host
namespace: biological_process
def: "The directed movement of a motile cell or organism on or near its host organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052118 ! positive energy taxis in host environment
is_a: GO:0052125 ! energy taxis on or near host
is_a: GO:0052246 ! positive energy taxis on or near other organism involved in symbiotic interaction

[Term]
id: GO:0052147
name: positive energy taxis in host
namespace: biological_process
def: "The directed movement of a motile cell or organism within its host organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "positive energy taxis within host" EXACT []
is_a: GO:0052118 ! positive energy taxis in host environment
is_a: GO:0052124 ! energy taxis within host
is_a: GO:0052247 ! positive energy taxis in other organism involved in symbiotic interaction

[Term]
id: GO:0052148
name: modulation by symbiont of host catalytic activity
namespace: biological_process
def: "The process in which an organism effects a change in host enzyme activity. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, GOC:tb]
subset: gosubset_prok
synonym: "modulation by symbiont of host enzyme activity" EXACT [GOC:tb]
synonym: "modulation of catalytic activity of host by symbiont" EXACT []
synonym: "regulation by symbiont of host catalytic activity" EXACT []
synonym: "regulation of catalytic activity of host by symbiont" EXACT []
synonym: "regulation of host catalytic activity by symbiont" EXACT []
is_a: GO:0052422 ! modulation by host of symbiont catalytic activity

[Term]
id: GO:0052149
name: modulation by symbiont of host peptidase activity
namespace: biological_process
def: "The process in which an organism effects a change in host peptidase activity, the catalysis of the hydrolysis of peptide bonds in a protein. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by symbiont of host protease activity" NARROW [GOC:bf]
is_a: GO:0052148 ! modulation by symbiont of host catalytic activity
is_a: GO:0052198 ! modulation of peptidase activity in other organism involved in symbiotic interaction

[Term]
id: GO:0052150
name: modulation by symbiont of host apoptotic process
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of programmed cell death in the host, where programmed cell death proceeds by apoptosis. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: Note that term is to be used to annotate gene products in the symbiont. To annotate host gene products, consider the biological process term 'regulation of apoptosis ; GO:0042981'.
subset: gosubset_prok
synonym: "modulation by organism of host apoptotic programmed cell death" EXACT []
synonym: "modulation by symbiont of host apoptosis" NARROW []
is_a: GO:0052040 ! modulation by symbiont of host programmed cell death
is_a: GO:0052433 ! modulation by organism of apoptotic process in other organism involved in symbiotic interaction

[Term]
id: GO:0052151
name: positive regulation by symbiont of host apoptotic process
namespace: biological_process
alt_id: GO:0033669
alt_id: GO:0052030
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in the host, where programmed cell death proceeds by apoptosis. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:mtg_pamgo_17jul06]
comment: Note that term is to be used to annotate gene products in the symbiont. To annotate host gene products, consider the biological process term 'positive regulation of apoptosis ; GO:0043065'.
subset: gosubset_prok
synonym: "activation by organism of host apoptosis" EXACT []
synonym: "activation by organism of host apoptotic programmed cell death" EXACT []
synonym: "activation by symbiont of host apoptosis" NARROW []
synonym: "induction by organism of host apoptotic programmed cell death" EXACT []
synonym: "induction by symbiont of host apoptosis" EXACT []
synonym: "positive regulation by organism of host apoptotic programmed cell death" EXACT []
synonym: "positive regulation by symbiont of host apoptosis" NARROW []
synonym: "stimulation by symbiont of host apoptosis" NARROW []
synonym: "up regulation by organism of host apoptotic programmed cell death" EXACT []
synonym: "up regulation by symbiont of host apoptosis" EXACT []
synonym: "up-regulation by organism of host apoptotic programmed cell death" EXACT []
synonym: "up-regulation by symbiont of host apoptosis" EXACT []
synonym: "upregulation by organism of host apoptotic programmed cell death" EXACT []
synonym: "upregulation by symbiont of host apoptosis" EXACT []
is_a: GO:0052150 ! modulation by symbiont of host apoptotic process
is_a: GO:0052501 ! positive regulation by organism of apoptotic process in other organism involved in symbiotic interaction

[Term]
id: GO:0052154
name: modulation by symbiont of host B-cell mediated immune response
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of the B-cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "regulation by organism of host B-cell mediated immune response" EXACT []
is_a: GO:0052293 ! modulation by organism of B-cell mediated immune response of other organism involved in symbiotic interaction
is_a: GO:0052553 ! modulation by symbiont of host immune response

[Term]
id: GO:0052155
name: modulation by symbiont of host cell-mediated immune response
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of any form of cell-based immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of host cell-based immune response" EXACT []
is_a: GO:0052294 ! modulation by organism of cell-mediated immune response of other organism involved in symbiotic interaction
is_a: GO:0052553 ! modulation by symbiont of host immune response

[Term]
id: GO:0052156
name: modulation by symbiont of host T-cell mediated immune response
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of the T-cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052155 ! modulation by symbiont of host cell-mediated immune response
is_a: GO:0052295 ! modulation by organism of T-cell mediated immune response of other organism involved in symbiotic interaction

[Term]
id: GO:0052157
name: modulation by symbiont of microbe-associated molecular pattern-induced host innate immune response
namespace: biological_process
def: "Any process that involves recognition of a microbe-associated molecular pattern, and by which an organism modulates the frequency, rate or extent of the innate immune response of the host organism; the innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mah]
subset: gosubset_prok
synonym: "modulation by symbiont of microbe-associated molecular pattern-induced host innate immunity" EXACT [GOC:pg]
synonym: "modulation by symbiont of pathogen-associated molecular pattern-induced host innate immunity" NARROW []
is_a: GO:0052167 ! modulation by symbiont of host innate immune response
is_a: GO:0052296 ! modulation by organism of microbe-associated molecular pattern-induced innate immune response in other organism involved in symbiotic interaction

[Term]
id: GO:0052158
name: modulation by symbiont of host resistance gene-dependent defense response
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of the resistance gene-dependent defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of defense response in host by specific elicitors" EXACT []
synonym: "modulation by organism of host gene-for-gene resistance" EXACT []
synonym: "modulation by organism of pathogen-race/host plant cultivar-specific resistance in symbiont" EXACT []
is_a: GO:0052297 ! modulation by organism of resistance gene-dependent defense response of other organism involved in symbiotic interaction
is_a: GO:0052553 ! modulation by symbiont of host immune response

[Term]
id: GO:0052159
name: modulation by symbiont of host induced systemic resistance
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of induced systemic resistance in the host organism; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by symbiont of induced systemic resistance in host" EXACT []
is_a: GO:0052298 ! modulation by organism of induced systemic resistance in other organism involved in symbiotic interaction
is_a: GO:0052553 ! modulation by symbiont of host immune response

[Term]
id: GO:0052160
name: modulation by symbiont of host systemic acquired resistance
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of systemic acquired resistance in the host organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by symbiont of systemic acquired resistance in host" EXACT []
is_a: GO:0052299 ! modulation by organism of systemic acquired resistance in other organism involved in symbiotic interaction
is_a: GO:0052553 ! modulation by symbiont of host immune response

[Term]
id: GO:0052161
name: modulation by symbiont of defense-related host cell wall thickening
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of host processes resulting in the thickening of its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of host defensive cell wall thickening" RELATED []
is_a: GO:0044068 ! modulation by symbiont of host cellular process
is_a: GO:0052031 ! modulation by symbiont of host defense response
is_a: GO:0052300 ! modulation by organism of defense-related cell wall thickening in other organism involved in symbiotic interaction

[Term]
id: GO:0052162
name: modulation by symbiont of defense-related host calcium ion flux
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of calcium ion fluxes as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of defense-related host Ca2+ flux" EXACT []
is_a: GO:0052031 ! modulation by symbiont of host defense response
is_a: GO:0052301 ! modulation by organism of defense-related calcium ion flux in other organism involved in symbiotic interaction

[Term]
id: GO:0052163
name: modulation by symbiont of defense-related host nitric oxide production
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of the production of nitric oxide as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of defense-related host NO production" EXACT []
is_a: GO:0052302 ! modulation by organism of defense-related nitric oxide production in other organism involved in symbiotic interaction
is_a: GO:0052553 ! modulation by symbiont of host immune response
is_a: GO:0052565 ! response to defense-related host nitric oxide production

[Term]
id: GO:0052164
name: modulation by symbiont of defense-related host reactive oxygen species production
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of the production of reactive oxygen species as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of defense-related host active oxygen species production" EXACT []
synonym: "modulation by organism of defense-related host AOS production" EXACT []
synonym: "modulation by organism of defense-related host metabolic burst" EXACT []
synonym: "modulation by organism of defense-related host oxidative burst" EXACT []
synonym: "modulation by organism of defense-related host reactive oxidative species production" EXACT []
synonym: "modulation by organism of defense-related host reactive oxygen intermediate production" EXACT []
synonym: "modulation by organism of defense-related host respiratory burst" EXACT []
synonym: "modulation by organism of defense-related host ROI production" EXACT []
synonym: "modulation by organism of defense-related host ROS production" EXACT []
is_a: GO:0052303 ! modulation by organism of defense-related reactive oxygen species production in other organism involved in symbiotic interaction
is_a: GO:0052553 ! modulation by symbiont of host immune response
is_a: GO:0052567 ! response to defense-related host reactive oxygen species production

[Term]
id: GO:0052165
name: modulation by symbiont of host phytoalexin production
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of production of phytoalexins as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052304 ! modulation by organism of phytoalexin production in other organism involved in symbiotic interaction
is_a: GO:0052553 ! modulation by symbiont of host immune response
is_a: GO:0052566 ! response to host phytoalexin production

[Term]
id: GO:0052166
name: positive regulation by symbiont of host innate immune response
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the innate immune response of the host organism; the innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by symbiont of host innate immunity" NARROW []
synonym: "induction of host innate immune response" NARROW []
synonym: "induction of host innate immunity" NARROW []
synonym: "positive regulation by symbiont of host innate immunity" EXACT [GOC:pg]
synonym: "positive regulation of host innate immune response" EXACT []
synonym: "stimulation by symbiont of host innate immunity" NARROW []
synonym: "up regulation by symbiont of host innate immunity" EXACT []
synonym: "up-regulation by symbiont of host innate immunity" EXACT []
synonym: "upregulation by symbiont of host innate immunity" EXACT []
is_a: GO:0052167 ! modulation by symbiont of host innate immune response
is_a: GO:0052305 ! positive regulation by organism of innate immune response in other organism involved in symbiotic interaction
is_a: GO:0052509 ! positive regulation by symbiont of host defense response
is_a: GO:0052556 ! positive regulation by symbiont of host immune response

[Term]
id: GO:0052167
name: modulation by symbiont of host innate immune response
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of the innate immune response of the host organism; the innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by symbiont of host innate immunity" EXACT [GOC:pg]
synonym: "modulation of host innate immune response" EXACT []
is_a: GO:0052306 ! modulation by organism of innate immune response in other organism involved in symbiotic interaction
is_a: GO:0052553 ! modulation by symbiont of host immune response

[Term]
id: GO:0052168
name: modulation by symbiont of defense-related host calcium-dependent protein kinase pathway
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of the host calcium-dependent protein kinase signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of defense-related host CDPK pathway" EXACT []
is_a: GO:0052031 ! modulation by symbiont of host defense response
is_a: GO:0052307 ! modulation by organism of defense-related calcium-dependent protein kinase pathway in other organism involved in symbiotic interaction

[Term]
id: GO:0052169
name: pathogen-associated molecular pattern dependent modulation by symbiont of host innate immune response
namespace: biological_process
def: "Any process that involves recognition of a pathogen-associated molecular pattern, and by which an organism modulates the frequency, rate or extent of the innate immune response of the host organism; the innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mah]
subset: gosubset_prok
synonym: "pathogen-associated molecular pattern dependent modulation by symbiont of host innate immunity" EXACT [GOC:pg]
is_a: GO:0052167 ! modulation by symbiont of host innate immune response
is_a: GO:0052308 ! pathogen-associated molecular pattern dependent modulation by organism of innate immune response in other organism involved in symbiotic interaction

[Term]
id: GO:0052170
name: negative regulation by symbiont of host innate immune response
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the innate immune response of the host organism, the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by symbiont of host innate immunity" EXACT []
synonym: "down-regulation by symbiont of host innate immunity" EXACT []
synonym: "downregulation by symbiont of host innate immunity" EXACT []
synonym: "inhibition by symbiont of host innate immunity" NARROW []
synonym: "negative regulation by symbiont of host innate immunity" EXACT [GOC:pg]
synonym: "negative regulation of host innate immune response" EXACT []
is_a: GO:0052037 ! negative regulation by symbiont of host defense response
is_a: GO:0052167 ! modulation by symbiont of host innate immune response
is_a: GO:0052309 ! negative regulation by organism of innate immune response in other organism involved in symbiotic interaction
is_a: GO:0052562 ! negative regulation by symbiont of host immune response

[Term]
id: GO:0052171
name: obsolete growth or development during symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring when the organism is in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'development during symbiotic interaction ; GO:0044111' and 'growth during symbiotic interaction ; GO:0044110'.
subset: gosubset_prok
synonym: "growth or development during symbiotic interaction" EXACT []
is_obsolete: true
consider: GO:0044110
consider: GO:0044111

[Term]
id: GO:0052172
name: metabolism by symbiont of host cell wall cellulose
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism involving cellulose in the cell wall of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0052175 ! metabolism by symbiont of host carbohydrate
is_a: GO:0052409 ! metabolism by organism of cell wall cellulose in other organism involved in symbiotic interaction

[Term]
id: GO:0052173
name: response to defenses of other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the defenses of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "response to defenses of other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0051707 ! response to other organism
relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism

[Term]
id: GO:0052174
name: metabolism by symbiont of host macromolecule
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism involving macromolecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0052002 ! metabolism by symbiont of substance in host
is_a: GO:0052229 ! metabolism of macromolecule in other organism involved in symbiotic interaction

[Term]
id: GO:0052175
name: metabolism by symbiont of host carbohydrate
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism involving carbohydrates within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0052174 ! metabolism by symbiont of host macromolecule
is_a: GO:0052407 ! metabolism by organism of carbohydrate in other organism involved in symbiotic interaction

[Term]
id: GO:0052176
name: metabolism by symbiont of host glucan
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism involving glucans within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0052175 ! metabolism by symbiont of host carbohydrate
is_a: GO:0052415 ! metabolism by organism of glucan in other organism involved in symbiotic interaction

[Term]
id: GO:0052177
name: metabolism by symbiont of host xylan
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism involving xylan within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0052175 ! metabolism by symbiont of host carbohydrate
is_a: GO:0052421 ! metabolism by organism of xylan in other organism involved in symbiotic interaction

[Term]
id: GO:0052178
name: metabolism by symbiont of host cell wall chitin
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism involving chitin in the cell wall of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0052175 ! metabolism by symbiont of host carbohydrate
is_a: GO:0052411 ! metabolism by organism of cell wall chitin in other organism involved in symbiotic interaction

[Term]
id: GO:0052179
name: metabolism by symbiont of host cell wall pectin
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism involving pectin in the cell wall of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0052175 ! metabolism by symbiont of host carbohydrate
is_a: GO:0052413 ! metabolism by organism of cell wall pectin in other organism involved in symbiotic interaction

[Term]
id: GO:0052180
name: negative regulation of peptidase activity in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of protease activity, the catalysis of the hydrolysis of peptide bonds in a protein, in a second organism, where the two organisms are in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb]
subset: gosubset_prok
synonym: "down regulation of protease activity in other organism during symbiotic interaction" EXACT []
synonym: "down-regulation of protease activity in other organism during symbiotic interaction" EXACT []
synonym: "downregulation of protease activity in other organism during symbiotic interaction" EXACT []
synonym: "inhibition of protease activity in other organism during symbiotic interaction" NARROW []
synonym: "negative regulation of protease activity in other organism during symbiotic interaction" EXACT [GOC:dph, GOC:tb]
is_a: GO:0035940 ! negative regulation of peptidase activity in other organism
is_a: GO:0052198 ! modulation of peptidase activity in other organism involved in symbiotic interaction
is_a: GO:0052199 ! negative regulation of catalytic activity in other organism involved in symbiotic interaction

[Term]
id: GO:0052181
name: modulation by host of symbiont defense response
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the resistance gene-dependent defense response of the symbiont. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0052201 ! response to symbiont defenses
is_a: GO:0052255 ! modulation by organism of defense response of other organism involved in symbiotic interaction

[Term]
id: GO:0052182
name: modification by host of symbiont morphology or physiology via secreted substance
namespace: biological_process
def: "The process in which an organism effects a change in the structure or function of a symbiont organism, mediated by a substance secreted by one of the organisms. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0051851 ! modification by host of symbiont morphology or physiology
is_a: GO:0052212 ! modification of morphology or physiology of other organism via secreted substance involved in symbiotic interaction
is_a: GO:0052213 ! interaction with symbiont via secreted substance involved in symbiotic interaction

[Term]
id: GO:0052183
name: modification by host of symbiont structure
namespace: biological_process
def: "The process in which an organism effects a change in an anatomical part or cellular component of the host organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0051851 ! modification by host of symbiont morphology or physiology
is_a: GO:0052185 ! modification of structure of other organism involved in symbiotic interaction

[Term]
id: GO:0052184
name: obsolete modulation by organism of symbiont hormone or growth regulator levels
namespace: biological_process
def: "OBSOLETE. The alteration by an organism of the levels of hormones or growth regulators in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of symbiont hormone or growth regulator levels" EXACT []
is_obsolete: true

[Term]
id: GO:0052185
name: modification of structure of other organism involved in symbiotic interaction
namespace: biological_process
def: "The process in which an organism effects a change in an anatomical part or cellular component of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modification of structure of other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0051817 ! modification of morphology or physiology of other organism involved in symbiotic interaction

[Term]
id: GO:0052186
name: modulation by organism of hormone or growth regulator levels in other organism involved in symbiotic interaction
namespace: biological_process
def: "The alteration by an organism of the levels of hormones or growth regulators in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of hormone or growth regulator levels in other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0051817 ! modification of morphology or physiology of other organism involved in symbiotic interaction

[Term]
id: GO:0052187
name: modification by host of symbiont cellular component
namespace: biological_process
def: "The process in which an organism effects a change in the structure or function of a symbiont cellular component. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0052183 ! modification by host of symbiont structure
is_a: GO:0052188 ! modification of cellular component in other organism involved in symbiotic interaction

[Term]
id: GO:0052188
name: modification of cellular component in other organism involved in symbiotic interaction
namespace: biological_process
def: "The process in which an organism effects a change in the structure or function of a cellular component in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modification of cellular component in other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0052185 ! modification of structure of other organism involved in symbiotic interaction

[Term]
id: GO:0052189
name: modulation by symbiont of defense-related host cell wall callose deposition
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of the deposition of callose by the host in its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052090 ! modulation by symbiont of defense-related host callose deposition
is_a: GO:0052161 ! modulation by symbiont of defense-related host cell wall thickening
is_a: GO:0052310 ! modulation by organism of defense-related cell wall callose deposition in other organism involved in symbiotic interaction

[Term]
id: GO:0052190
name: modulation by symbiont of host phagocytosis
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0044068 ! modulation by symbiont of host cellular process
is_a: GO:0052231 ! modulation of phagocytosis in other organism involved in symbiotic interaction

[Term]
id: GO:0052191
name: positive regulation by symbiont of host phagocytosis
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "activation by symbiont of host phagocytosis" NARROW []
synonym: "stimulation by symbiont of host phagocytosis" NARROW []
synonym: "up regulation by symbiont of host phagocytosis" EXACT []
synonym: "up-regulation by symbiont of host phagocytosis" EXACT []
synonym: "upregulation by symbiont of host phagocytosis" EXACT []
is_a: GO:0052190 ! modulation by symbiont of host phagocytosis
is_a: GO:0052522 ! positive regulation by organism of phagocytosis in other organism involved in symbiotic interaction

[Term]
id: GO:0052192
name: movement in environment of other organism involved in symbiotic interaction
namespace: biological_process
def: "The directed movement of an organism or motile cell on, within or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "locomotion in environment of other organism during symbiotic interaction" RELATED []
synonym: "movement in environment of other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0040011 ! locomotion
relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism

[Term]
id: GO:0052193
name: movement in symbiont environment
namespace: biological_process
def: "The directed movement of an organism or motile cell on, within or near its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0051702 ! interaction with symbiont
is_a: GO:0052192 ! movement in environment of other organism involved in symbiotic interaction

[Term]
id: GO:0052194
name: movement on or near symbiont
namespace: biological_process
def: "The directed movement of an organism or motile cell on or near its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052193 ! movement in symbiont environment
is_a: GO:0052195 ! movement on or near other organism involved in symbiotic interaction

[Term]
id: GO:0052195
name: movement on or near other organism involved in symbiotic interaction
namespace: biological_process
def: "The directed movement of an organism or motile cell on or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "movement on or near other organism during symbiotic interaction" RELATED [GOC:tb]
is_a: GO:0052192 ! movement in environment of other organism involved in symbiotic interaction

[Term]
id: GO:0052196
name: negative regulation by host of symbiont defense response
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "down regulation by host of symbiont defense response" EXACT []
synonym: "down-regulation by host of symbiont defense response" EXACT []
synonym: "downregulation by host of symbiont defense response" EXACT []
synonym: "inhibition by host of symbiont defense response" NARROW []
is_a: GO:0051859 ! suppression of symbiont defenses
is_a: GO:0052181 ! modulation by host of symbiont defense response
is_a: GO:0052261 ! suppression of defense response of other organism involved in symbiotic interaction

[Term]
id: GO:0052197
name: positive regulation by host of symbiont defense response
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "activation by host of symbiont defense response" NARROW []
synonym: "stimulation by host of symbiont defense response" NARROW []
synonym: "up regulation by host of symbiont defense response" EXACT []
synonym: "up-regulation by host of symbiont defense response" EXACT []
synonym: "upregulation by host of symbiont defense response" EXACT []
is_a: GO:0052181 ! modulation by host of symbiont defense response
is_a: GO:0052510 ! positive regulation by organism of defense response of other organism involved in symbiotic interaction

[Term]
id: GO:0052198
name: modulation of peptidase activity in other organism involved in symbiotic interaction
namespace: biological_process
def: "The process in which an organism effects a change in peptidase activity, the catalysis of the hydrolysis of peptide bonds in a protein, in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation of protease activity in other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "modulation of protease activity in other organism involved in symbiotic interaction" NARROW [GOC:bf]
is_a: GO:0052203 ! modulation of catalytic activity in other organism involved in symbiotic interaction

[Term]
id: GO:0052199
name: negative regulation of catalytic activity in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of enzyme activity in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, GOC:tb]
subset: gosubset_prok
synonym: "down regulation of enzyme activity in other organism during symbiotic interaction" RELATED []
synonym: "down-regulation of enzyme activity in other organism during symbiotic interaction" RELATED []
synonym: "downregulation of enzyme activity in other organism during symbiotic interaction" RELATED []
synonym: "inhibition of enzyme activity in other organism" EXACT []
synonym: "inhibition of enzyme activity in other organism during symbiotic interaction" NARROW []
synonym: "negative regulation of enzyme activity in other organism during symbiotic interaction" EXACT [GOC:tb]
is_a: GO:0043086 ! negative regulation of catalytic activity
is_a: GO:0052203 ! modulation of catalytic activity in other organism involved in symbiotic interaction
is_a: GO:0052204 ! negative regulation of molecular function in other organism involved in symbiotic interaction

[Term]
id: GO:0052200
name: response to host defenses
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the defenses of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052173 ! response to defenses of other organism involved in symbiotic interaction
is_a: GO:0075136 ! response to host

[Term]
id: GO:0052201
name: response to symbiont defenses
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the defenses of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0009608 ! response to symbiont
is_a: GO:0052173 ! response to defenses of other organism involved in symbiotic interaction

[Term]
id: GO:0052202
name: negative regulation by symbiont of defense-related host cell wall callose deposition
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the deposition of callose by the host in its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by symbiont of defense-related host cell wall callose deposition" EXACT []
synonym: "down-regulation by symbiont of defense-related host cell wall callose deposition" EXACT []
synonym: "downregulation by symbiont of defense-related host cell wall callose deposition" EXACT []
synonym: "inhibition by symbiont of defense-related host cell wall callose deposition" NARROW []
is_a: GO:0052087 ! negative regulation by symbiont of defense-related host callose deposition
is_a: GO:0052189 ! modulation by symbiont of defense-related host cell wall callose deposition
is_a: GO:0052311 ! negative regulation by organism of defense-related cell wall callose deposition in other organism involved in symbiotic interaction

[Term]
id: GO:0052203
name: modulation of catalytic activity in other organism involved in symbiotic interaction
namespace: biological_process
def: "The process in which an organism effects a change in enzyme activity in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, GOC:tb]
subset: gosubset_prok
synonym: "modulation of enzyme activity within other organism during symbiotic interaction" EXACT [GOC:tb]
is_a: GO:0050790 ! regulation of catalytic activity
is_a: GO:0052205 ! modulation of molecular function in other organism involved in symbiotic interaction

[Term]
id: GO:0052204
name: negative regulation of molecular function in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the functional activity of proteins in a second organism, where the two organisms are in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb]
subset: gosubset_prok
synonym: "down regulation of protein function in other organism during symbiotic interaction" EXACT []
synonym: "down-regulation of protein function in other organism during symbiotic interaction" EXACT []
synonym: "downregulation of protein function in other organism during symbiotic interaction" EXACT []
synonym: "inhibition of protein function in other organism" EXACT []
synonym: "inhibition of protein function in other organism during symbiotic interaction" NARROW []
synonym: "negative regulation of protein function in other organism during symbiotic interaction" EXACT [GOC:dph, GOC:tb]
is_a: GO:0044362 ! negative regulation of molecular function in other organism
is_a: GO:0052205 ! modulation of molecular function in other organism involved in symbiotic interaction

[Term]
id: GO:0052205
name: modulation of molecular function in other organism involved in symbiotic interaction
namespace: biological_process
def: "The process in which an organism effects a change in the function of proteins in a second organism, where the two organisms are in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb]
subset: gosubset_prok
synonym: "modification of molecular function in other organism during symbiotic interaction" EXACT []
synonym: "modification of protein function in other organism during symbiotic interaction" EXACT [GOC:dph, GOC:tb]
synonym: "modulation of molecular function in other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0044359 ! modulation of molecular function in other organism
is_a: GO:0051817 ! modification of morphology or physiology of other organism involved in symbiotic interaction

[Term]
id: GO:0052206
name: modification of morphology or physiology of other organism via protein secreted by type II secretion system involved in symbiotic interaction
namespace: biological_process
def: "The process in which an organism effects a change in the structure or function of a second organism, mediated by a substance secreted by a type II secretion system in the first organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modification of morphology or physiology of other organism via protein secreted by type II secretion system during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0052211 ! interaction with other organism via protein secreted by type II secretion system involved in symbiotic interaction
is_a: GO:0052212 ! modification of morphology or physiology of other organism via secreted substance involved in symbiotic interaction

[Term]
id: GO:0052207
name: modification of morphology or physiology of other organism via protein secreted by type III secretion system involved in symbiotic interaction
namespace: biological_process
def: "The process in which an organism effects a change in the structure or function of a second organism, mediated by a substance secreted by a type III secretion system in the first organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modification of morphology or physiology of other organism via protein secreted by type III secretion system during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0052210 ! interaction with other organism via protein secreted by type III secretion system involved in symbiotic interaction
is_a: GO:0052212 ! modification of morphology or physiology of other organism via secreted substance involved in symbiotic interaction

[Term]
id: GO:0052208
name: modification of morphology or physiology of other organism via substance secreted by type IV secretion system involved in symbiotic interaction
namespace: biological_process
def: "The process in which an organism effects a change in the structure or function of a second organism, mediated by a substance secreted by a type IV secretion system in the first organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modification of morphology or physiology of other organism via substance secreted by type IV secretion system during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0052209 ! interaction with other organism via substance secreted by type IV secretion system involved in symbiotic interaction
is_a: GO:0052212 ! modification of morphology or physiology of other organism via secreted substance involved in symbiotic interaction

[Term]
id: GO:0052209
name: interaction with other organism via substance secreted by type IV secretion system involved in symbiotic interaction
namespace: biological_process
def: "An interaction with a second organism mediated by a substance secreted by the first organism by a type IV secretion system, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "interaction with other organism via substance secreted by type IV secretion system during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0052047 ! interaction with other organism via secreted substance involved in symbiotic interaction

[Term]
id: GO:0052210
name: interaction with other organism via protein secreted by type III secretion system involved in symbiotic interaction
namespace: biological_process
def: "An interaction with a second organism mediated by a substance secreted by the first organism by a type III secretion system, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "interaction with other organism via protein secreted by type III secretion system during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0052047 ! interaction with other organism via secreted substance involved in symbiotic interaction

[Term]
id: GO:0052211
name: interaction with other organism via protein secreted by type II secretion system involved in symbiotic interaction
namespace: biological_process
def: "An interaction with a second organism mediated by a substance secreted by the first organism by a type II secretion system, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "interaction with other organism via protein secreted by type II secretion system during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0052047 ! interaction with other organism via secreted substance involved in symbiotic interaction

[Term]
id: GO:0052212
name: modification of morphology or physiology of other organism via secreted substance involved in symbiotic interaction
namespace: biological_process
def: "The process in which an organism effects a change in the structure or function of a second organism, mediated by a substance secreted by one of the organisms, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modification of host morphology or physiology via effector molecule" NARROW []
synonym: "modification of host morphology or physiology via ellicitor" NARROW []
synonym: "modification of morphology or physiology of other organism via secreted substance during symbiotic interaction" RELATED [GOC:tb]
is_a: GO:0051817 ! modification of morphology or physiology of other organism involved in symbiotic interaction
is_a: GO:0052047 ! interaction with other organism via secreted substance involved in symbiotic interaction

[Term]
id: GO:0052213
name: interaction with symbiont via secreted substance involved in symbiotic interaction
namespace: biological_process
def: "An interaction with the symbiont organism mediated by a substance secreted by the other (host) organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "interaction with symbiont via secreted substance during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0051702 ! interaction with symbiont
is_a: GO:0052047 ! interaction with other organism via secreted substance involved in symbiotic interaction

[Term]
id: GO:0052214
name: metabolism of substance in other organism involved in symbiotic interaction
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "metabolism of substance in other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0044033 ! multi-organism metabolic process
relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism

[Term]
id: GO:0052215
name: energy taxis in environment of other organism involved in symbiotic interaction
namespace: biological_process
def: "The directed movement of a motile cell or organism in the environment of a second organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "energy taxis in environment of other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "energy taxis in response to environment of other organism" EXACT []
is_a: GO:0009453 ! energy taxis
is_a: GO:0052192 ! movement in environment of other organism involved in symbiotic interaction

[Term]
id: GO:0052216
name: chemotaxis in environment of other organism involved in symbiotic interaction
namespace: biological_process
def: "The directed movement of a motile cell or organism in response to a specific chemical concentration gradient on, within or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "chemotaxis in environment of other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "chemotaxis in response to environment of other organism" EXACT []
is_a: GO:0006935 ! chemotaxis
is_a: GO:0052192 ! movement in environment of other organism involved in symbiotic interaction

[Term]
id: GO:0052217
name: aerotaxis in environment of other organism involved in symbiotic interaction
namespace: biological_process
def: "The movement of a motile cell or organism in response to environmental oxygen on, within or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "aerotaxis in environment of other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "aerotaxis in response to environment of other organism" EXACT []
is_a: GO:0009454 ! aerotaxis
is_a: GO:0052215 ! energy taxis in environment of other organism involved in symbiotic interaction
is_a: GO:0052216 ! chemotaxis in environment of other organism involved in symbiotic interaction

[Term]
id: GO:0052218
name: positive energy taxis in environment of other organism involved in symbiotic interaction
namespace: biological_process
def: "The directed movement of a motile cell or organism on, within or near a second organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "positive energy taxis in environment of other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "positive energy taxis in response to environment of other organism" EXACT []
is_a: GO:0052128 ! positive energy taxis
is_a: GO:0052215 ! energy taxis in environment of other organism involved in symbiotic interaction

[Term]
id: GO:0052219
name: negative energy taxis in environment of other organism involved in symbiotic interaction
namespace: biological_process
def: "The directed movement of a motile cell or organism on, within or near a second organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "negative energy taxis in environment of other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "negative energy taxis in response to environment of other organism" EXACT []
is_a: GO:0052129 ! negative energy taxis
is_a: GO:0052215 ! energy taxis in environment of other organism involved in symbiotic interaction

[Term]
id: GO:0052220
name: positive aerotaxis in environment of other organism involved in symbiotic interaction
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen on, within or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "positive aerotaxis in environment of other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "positive aerotaxis in response to environment of other organism" EXACT []
is_a: GO:0052131 ! positive aerotaxis
is_a: GO:0052217 ! aerotaxis in environment of other organism involved in symbiotic interaction
is_a: GO:0052218 ! positive energy taxis in environment of other organism involved in symbiotic interaction
is_a: GO:0052221 ! positive chemotaxis in environment of other organism involved in symbiotic interaction

[Term]
id: GO:0052221
name: positive chemotaxis in environment of other organism involved in symbiotic interaction
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a higher concentration of a chemical on, within or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "positive chemotaxis in environment of other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "positive chemotaxis in response to environment of other organism" EXACT []
is_a: GO:0050918 ! positive chemotaxis
is_a: GO:0052216 ! chemotaxis in environment of other organism involved in symbiotic interaction

[Term]
id: GO:0052222
name: negative aerotaxis in environment of other organism involved in symbiotic interaction
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen on, within or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "negative aerotaxis in environment of other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "negative aerotaxis in response to environment of other organism" EXACT []
is_a: GO:0052130 ! negative aerotaxis
is_a: GO:0052217 ! aerotaxis in environment of other organism involved in symbiotic interaction
is_a: GO:0052219 ! negative energy taxis in environment of other organism involved in symbiotic interaction
is_a: GO:0052223 ! negative chemotaxis in environment of other organism involved in symbiotic interaction

[Term]
id: GO:0052223
name: negative chemotaxis in environment of other organism involved in symbiotic interaction
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a lower concentration of a specific chemical on, within or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "negative chemotaxis in environment of other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "negative chemotaxis in response to environment of other organism" EXACT []
is_a: GO:0050919 ! negative chemotaxis
is_a: GO:0052216 ! chemotaxis in environment of other organism involved in symbiotic interaction

[Term]
id: GO:0052224
name: energy taxis in other organism involved in symbiotic interaction
namespace: biological_process
def: "The directed movement of a motile cell or organism within a second organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "energy taxis in other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "energy taxis within other organism during symbiotic interaction" EXACT []
is_a: GO:0051814 ! movement in other organism involved in symbiotic interaction
is_a: GO:0052215 ! energy taxis in environment of other organism involved in symbiotic interaction

[Term]
id: GO:0052225
name: energy taxis on or near other organism involved in symbiotic interaction
namespace: biological_process
def: "The directed movement of a motile cell or organism on or near a second organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "energy taxis on or near other organism during symbiotic interaction" RELATED [GOC:tb]
is_a: GO:0052195 ! movement on or near other organism involved in symbiotic interaction
is_a: GO:0052215 ! energy taxis in environment of other organism involved in symbiotic interaction

[Term]
id: GO:0052226
name: biosynthesis of substance in other organism involved in symbiotic interaction
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism in a second organism resulting in the formation of substances, where the two organisms are in a symbiotic interaction." [ISBN:0198547684]
synonym: "biosynthesis of substance in other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0044034 ! multi-organism biosynthetic process
is_a: GO:0052214 ! metabolism of substance in other organism involved in symbiotic interaction

[Term]
id: GO:0052227
name: catabolism of substance in other organism involved in symbiotic interaction
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism in a second organism resulting in the breakdown of substances, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "catabolism of substance in other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0044035 ! multi-organism catabolic process
is_a: GO:0052214 ! metabolism of substance in other organism involved in symbiotic interaction

[Term]
id: GO:0052228
name: metabolism by symbiont of host protein
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism involving protein macromolecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052174 ! metabolism by symbiont of host macromolecule
is_a: GO:0052418 ! metabolism by organism of protein in other organism involved in symbiotic interaction

[Term]
id: GO:0052229
name: metabolism of macromolecule in other organism involved in symbiotic interaction
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism involving macromolecules within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "metabolism of macromolecule in other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0043170 ! macromolecule metabolic process
is_a: GO:0052214 ! metabolism of substance in other organism involved in symbiotic interaction

[Term]
id: GO:0052230
name: modulation of intracellular transport in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of the directed movement of substances within the cell or cells of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation of intracellular trafficking in other organism" EXACT []
synonym: "modulation of intracellular transport in other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0032386 ! regulation of intracellular transport
is_a: GO:0051817 ! modification of morphology or physiology of other organism involved in symbiotic interaction

[Term]
id: GO:0052231
name: modulation of phagocytosis in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "modulation of phagocytosis in other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0050764 ! regulation of phagocytosis
is_a: GO:0051817 ! modification of morphology or physiology of other organism involved in symbiotic interaction

[Term]
id: GO:0052232
name: positive aerotaxis on or near other organism involved in symbiotic interaction
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen on or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "positive aerotaxis on or near other organism during symbiotic interaction" RELATED [GOC:tb]
is_a: GO:0052220 ! positive aerotaxis in environment of other organism involved in symbiotic interaction
is_a: GO:0052238 ! aerotaxis on or near other organism involved in symbiotic interaction
is_a: GO:0052241 ! positive chemotaxis on or near other organism involved in symbiotic interaction
is_a: GO:0052246 ! positive energy taxis on or near other organism involved in symbiotic interaction

[Term]
id: GO:0052233
name: positive aerotaxis in other organism involved in symbiotic interaction
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "positive aerotaxis in other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "positive aerotaxis within other organism during symbiotic interaction" EXACT []
is_a: GO:0052220 ! positive aerotaxis in environment of other organism involved in symbiotic interaction
is_a: GO:0052237 ! aerotaxis in other organism involved in symbiotic interaction
is_a: GO:0052240 ! positive chemotaxis in other organism involved in symbiotic interaction
is_a: GO:0052247 ! positive energy taxis in other organism involved in symbiotic interaction

[Term]
id: GO:0052234
name: negative aerotaxis on or near other organism involved in symbiotic interaction
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen on or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "negative aerotaxis on or near other organism during symbiotic interaction" RELATED [GOC:tb]
is_a: GO:0052222 ! negative aerotaxis in environment of other organism involved in symbiotic interaction
is_a: GO:0052236 ! negative chemotaxis on or near other organism involved in symbiotic interaction
is_a: GO:0052238 ! aerotaxis on or near other organism involved in symbiotic interaction
is_a: GO:0052245 ! negative energy taxis on or near other organism involved in symbiotic interaction

[Term]
id: GO:0052235
name: negative aerotaxis in other organism involved in symbiotic interaction
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "negative aerotaxis in other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "negative aerotaxis within other organism during symbiotic interaction" EXACT []
is_a: GO:0052222 ! negative aerotaxis in environment of other organism involved in symbiotic interaction
is_a: GO:0052237 ! aerotaxis in other organism involved in symbiotic interaction
is_a: GO:0052239 ! negative chemotaxis in other organism involved in symbiotic interaction
is_a: GO:0052244 ! negative energy taxis in other organism involved in symbiotic interaction

[Term]
id: GO:0052236
name: negative chemotaxis on or near other organism involved in symbiotic interaction
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a lower concentration of a specific chemical on or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "negative chemotaxis on or near other organism during symbiotic interaction" RELATED [GOC:tb]
is_a: GO:0052223 ! negative chemotaxis in environment of other organism involved in symbiotic interaction
is_a: GO:0052243 ! chemotaxis on or near other organism involved in symbiotic interaction

[Term]
id: GO:0052237
name: aerotaxis in other organism involved in symbiotic interaction
namespace: biological_process
def: "The movement of a motile cell or organism in response to environmental oxygen within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "aerotaxis in other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "aerotaxis within other organism during symbiotic interaction" EXACT []
is_a: GO:0052217 ! aerotaxis in environment of other organism involved in symbiotic interaction
is_a: GO:0052224 ! energy taxis in other organism involved in symbiotic interaction
is_a: GO:0052242 ! chemotaxis in other organism involved in symbiotic interaction

[Term]
id: GO:0052238
name: aerotaxis on or near other organism involved in symbiotic interaction
namespace: biological_process
def: "The movement of a motile cell or organism in response to environmental oxygen on or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "aerotaxis on or near other organism during symbiotic interaction" RELATED [GOC:tb]
is_a: GO:0052217 ! aerotaxis in environment of other organism involved in symbiotic interaction
is_a: GO:0052225 ! energy taxis on or near other organism involved in symbiotic interaction
is_a: GO:0052243 ! chemotaxis on or near other organism involved in symbiotic interaction

[Term]
id: GO:0052239
name: negative chemotaxis in other organism involved in symbiotic interaction
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a lower concentration of a specific chemical within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "negative chemotaxis in other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "negative chemotaxis within other organism during symbiotic interaction" RELATED []
is_a: GO:0052223 ! negative chemotaxis in environment of other organism involved in symbiotic interaction
is_a: GO:0052242 ! chemotaxis in other organism involved in symbiotic interaction

[Term]
id: GO:0052240
name: positive chemotaxis in other organism involved in symbiotic interaction
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a higher concentration of a specific chemical within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "positive chemotaxis in other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "positive chemotaxis within other organism during symbiotic interaction" RELATED []
is_a: GO:0052221 ! positive chemotaxis in environment of other organism involved in symbiotic interaction
is_a: GO:0052242 ! chemotaxis in other organism involved in symbiotic interaction

[Term]
id: GO:0052241
name: positive chemotaxis on or near other organism involved in symbiotic interaction
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a higher concentration of a specific chemical on or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "positive chemotaxis on or near other organism during symbiotic interaction" RELATED [GOC:tb]
is_a: GO:0052221 ! positive chemotaxis in environment of other organism involved in symbiotic interaction
is_a: GO:0052243 ! chemotaxis on or near other organism involved in symbiotic interaction

[Term]
id: GO:0052242
name: chemotaxis in other organism involved in symbiotic interaction
namespace: biological_process
def: "The directed movement of a motile cell or organism in response to a specific chemical concentration gradient within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "chemotaxis in other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "chemotaxis within other organism during symbiotic interaction" EXACT []
is_a: GO:0051814 ! movement in other organism involved in symbiotic interaction
is_a: GO:0052216 ! chemotaxis in environment of other organism involved in symbiotic interaction

[Term]
id: GO:0052243
name: chemotaxis on or near other organism involved in symbiotic interaction
namespace: biological_process
def: "The directed movement of a motile cell or organism in response to a specific chemical concentration gradient on or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "chemotaxis on or near other organism during symbiotic interaction" RELATED [GOC:tb]
is_a: GO:0052195 ! movement on or near other organism involved in symbiotic interaction
is_a: GO:0052216 ! chemotaxis in environment of other organism involved in symbiotic interaction

[Term]
id: GO:0052244
name: negative energy taxis in other organism involved in symbiotic interaction
namespace: biological_process
def: "The directed movement of a motile cell or organism within a second organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "negative energy taxis in other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "negative energy taxis within other organism during symbiotic interaction" RELATED []
is_a: GO:0052219 ! negative energy taxis in environment of other organism involved in symbiotic interaction
is_a: GO:0052224 ! energy taxis in other organism involved in symbiotic interaction

[Term]
id: GO:0052245
name: negative energy taxis on or near other organism involved in symbiotic interaction
namespace: biological_process
def: "The directed movement of a motile cell or organism on or near a second organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "negative energy taxis on or near other organism during symbiotic interaction" RELATED [GOC:tb]
is_a: GO:0052219 ! negative energy taxis in environment of other organism involved in symbiotic interaction
is_a: GO:0052225 ! energy taxis on or near other organism involved in symbiotic interaction

[Term]
id: GO:0052246
name: positive energy taxis on or near other organism involved in symbiotic interaction
namespace: biological_process
def: "The directed movement of a motile cell or organism on or near a second organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "positive energy taxis on or near other organism during symbiotic interaction" RELATED [GOC:tb]
is_a: GO:0052218 ! positive energy taxis in environment of other organism involved in symbiotic interaction
is_a: GO:0052225 ! energy taxis on or near other organism involved in symbiotic interaction

[Term]
id: GO:0052247
name: positive energy taxis in other organism involved in symbiotic interaction
namespace: biological_process
def: "The directed movement of a motile cell or organism within a second organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "positive energy taxis in other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "positive energy taxis within other organism during symbiotic interaction" RELATED []
is_a: GO:0052218 ! positive energy taxis in environment of other organism involved in symbiotic interaction
is_a: GO:0052224 ! energy taxis in other organism involved in symbiotic interaction

[Term]
id: GO:0052248
name: modulation of programmed cell death in other organism involved in symbiotic interaction
namespace: biological_process
alt_id: GO:0052459
def: "Any process in which an organism modulates the frequency, rate or extent of programmed cell death in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of non-apoptotic programmed cell death in other organism during symbiotic interaction" NARROW []
synonym: "modulation of programmed cell death in other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0044531 ! modulation of programmed cell death in other organism
is_a: GO:0051817 ! modification of morphology or physiology of other organism involved in symbiotic interaction

[Term]
id: GO:0052249
name: modulation of RNA levels in other organism involved in symbiotic interaction
namespace: biological_process
def: "The alteration by an organism of the levels of RNA in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation of RNA levels in other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0051817 ! modification of morphology or physiology of other organism involved in symbiotic interaction

[Term]
id: GO:0052250
name: modulation of signal transduction in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of the signal transduction pathways, the cascade of processes by which a signal interacts with a receptor, occurring in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation of signal transduction pathway in other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0044501 ! modulation of signal transduction in other organism
is_a: GO:0051817 ! modification of morphology or physiology of other organism involved in symbiotic interaction

[Term]
id: GO:0052251
name: induction by organism of defense response of other organism involved in symbiotic interaction
namespace: biological_process
def: "The activation by an organism of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
synonym: "activation of defense response of other organism" EXACT []
synonym: "induction by organism of defense response of other organism during symbiotic interaction" RELATED [GOC:tb]
is_a: GO:0052510 ! positive regulation by organism of defense response of other organism involved in symbiotic interaction

[Term]
id: GO:0052252
name: negative regulation by organism of defense-related salicylic acid-mediated signal transduction pathway of other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of salicylic acid-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by organism of defense-related salicylic acid-mediated signal transduction pathway of other organism during symbiotic interaction" RELATED []
synonym: "down-regulation by organism of defense-related salicylic acid-mediated signal transduction pathway of other organism during symbiotic interaction" RELATED []
synonym: "downregulation by organism of defense-related salicylic acid-mediated signal transduction pathway of other organism during symbiotic interaction" RELATED []
synonym: "inhibition by organism of defense-related salicylic acid-mediated signal transduction pathway of other organism during symbiotic interaction" NARROW []
synonym: "negative modulation by organism of defense-related SA-mediated signal transduction pathway in other organism" EXACT []
synonym: "negative modulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism" EXACT []
synonym: "negative regulation by organism of defense-related SA-mediated signal transduction pathway in other organism" EXACT []
synonym: "negative regulation by organism of defense-related salicylic acid-mediated signal transduction pathway of other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0052253 ! negative regulation by organism of salicylic acid-mediated defense response of other organism involved in symbiotic interaction
is_a: GO:0052445 ! modulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction
is_a: GO:0052493 ! negative regulation by organism of signal transduction in other organism involved in symbiotic interaction

[Term]
id: GO:0052253
name: negative regulation by organism of salicylic acid-mediated defense response of other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the salicylic acid-mediated defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction" RELATED []
synonym: "down-regulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction" RELATED []
synonym: "downregulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction" RELATED []
synonym: "inhibition by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction" NARROW []
synonym: "negative regulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "negative regulation of SA-mediated defense response of other organism" EXACT []
synonym: "suppression by organism of salicylic acid-mediated defense response of other organism" EXACT []
synonym: "suppression of SA mediated defense response of other organism" EXACT []
is_a: GO:0052261 ! suppression of defense response of other organism involved in symbiotic interaction
is_a: GO:0052284 ! modulation by organism of salicylic acid-mediated defense response of other organism involved in symbiotic interaction

[Term]
id: GO:0052254
name: negative regulation by organism of ethylene-mediated defense response of other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the ethylene-mediated defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction" RELATED []
synonym: "down-regulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction" RELATED []
synonym: "downregulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction" RELATED []
synonym: "inhibition by organism of ethylene-mediated defense response of other organism during symbiotic interaction" NARROW []
synonym: "negative regulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "suppression by organism of ethylene-mediated defense response of other organism" EXACT []
is_a: GO:0052261 ! suppression of defense response of other organism involved in symbiotic interaction
is_a: GO:0052279 ! modulation by organism of ethylene-mediated defense response of other organism involved in symbiotic interaction

[Term]
id: GO:0052255
name: modulation by organism of defense response of other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of the defense response of a second organism, the response mounted by that organism in response to the presence of the first organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of defense response of other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0051817 ! modification of morphology or physiology of other organism involved in symbiotic interaction
is_a: GO:0052173 ! response to defenses of other organism involved in symbiotic interaction

[Term]
id: GO:0052256
name: modulation by organism of inflammatory response of other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents, of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of inflammatory response of other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0050727 ! regulation of inflammatory response
is_a: GO:0052255 ! modulation by organism of defense response of other organism involved in symbiotic interaction

[Term]
id: GO:0052257
name: pathogen-associated molecular pattern dependent induction by organism of innate immune response of other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process that involves recognition of a pathogen-associated molecular pattern, and by which an organism activates, maintains or increases the frequency, rate or extent of the innate immune response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mah]
subset: gosubset_prok
synonym: "general elicitor dependent induction of innate immunity of other organism" EXACT []
synonym: "general elicitor-dependent induction of innate immunity of other organism" EXACT []
synonym: "MAMP dependent induction of innate immunity of other organism" EXACT []
synonym: "MAMP-dependent induction of innate immunity of other organism" EXACT []
synonym: "PAMP dependent induction of innate immunity of other organism" EXACT []
synonym: "PAMP-dependent induction of innate immunity of other organism" EXACT []
synonym: "pathogen-associated molecular pattern dependent induction by organism of innate immunity of other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "pathogen-associated molecular pattern dependent induction by organism of innate immunity of other organism involved in symbiotic interaction" EXACT [GOC:pg]
is_a: GO:0052305 ! positive regulation by organism of innate immune response in other organism involved in symbiotic interaction
is_a: GO:0052308 ! pathogen-associated molecular pattern dependent modulation by organism of innate immune response in other organism involved in symbiotic interaction

[Term]
id: GO:0052258
name: negative regulation by organism of pathogen-associated molecular pattern-induced innate immune response of other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process that involves recognition of a microbe-associated molecular pattern, and by which an organism stops, prevents, or reduces the frequency, rate or extent of the innate immune response, the first line of defense against infection, of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation by organism of pathogen-associated molecular pattern-induced innate immunity of other organism during symbiotic interaction" RELATED []
synonym: "down-regulation by organism of pathogen-associated molecular pattern-induced innate immunity of other organism during symbiotic interaction" RELATED []
synonym: "downregulation by organism of pathogen-associated molecular pattern-induced innate immunity of other organism during symbiotic interaction" RELATED []
synonym: "inhibition by organism of pathogen-associated molecular pattern-induced innate immunity of other organism during symbiotic interaction" NARROW []
synonym: "negative regulation by organism of pathogen-associated molecular pattern-induced innate immunity of other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "negative regulation by organism of pathogen-associated molecular pattern-induced innate immunity of other organism involved in symbiotic interaction" EXACT [GOC:pg]
synonym: "suppression of general elicitor induced innate immunity of other organism" EXACT []
synonym: "suppression of general elicitor-induced innate immunity of other organism" EXACT []
synonym: "suppression of MAMP induced innate immunity of other organism" EXACT []
synonym: "suppression of MAMP-induced innate immunity of other organism" EXACT []
synonym: "suppression of PAMP induced innate immunity of other organism" EXACT []
synonym: "suppression of PAMP-induced innate immunity of other organism" EXACT []
synonym: "suppression of pathogen-associated molecular pattern-induced innate immunity of other organism" EXACT []
is_a: GO:0052296 ! modulation by organism of microbe-associated molecular pattern-induced innate immune response in other organism involved in symbiotic interaction
is_a: GO:0052309 ! negative regulation by organism of innate immune response in other organism involved in symbiotic interaction

[Term]
id: GO:0052259
name: positive regulation by organism of inflammatory response of other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents, of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of inflammatory response of other organism during symbiotic interaction" NARROW []
synonym: "positive regulation by organism of inflammatory response of other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "stimulation by organism of inflammatory response of other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of inflammatory response of other organism during symbiotic interaction" RELATED []
synonym: "up-regulation by organism of inflammatory response of other organism during symbiotic interaction" RELATED []
synonym: "upregulation by organism of inflammatory response of other organism during symbiotic interaction" RELATED []
is_a: GO:0050729 ! positive regulation of inflammatory response
is_a: GO:0052256 ! modulation by organism of inflammatory response of other organism involved in symbiotic interaction
is_a: GO:0052510 ! positive regulation by organism of defense response of other organism involved in symbiotic interaction

[Term]
id: GO:0052260
name: negative regulation by organism of inflammatory response of other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the inflammatory response; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents, of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by organism of inflammatory response of other organism during symbiotic interaction" RELATED []
synonym: "down-regulation by organism of inflammatory response of other organism during symbiotic interaction" RELATED []
synonym: "downregulation by organism of inflammatory response of other organism during symbiotic interaction" RELATED []
synonym: "inhibition by organism of inflammatory response of other organism during symbiotic interaction" NARROW []
synonym: "negative regulation by organism of inflammatory response of other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0050728 ! negative regulation of inflammatory response
is_a: GO:0052256 ! modulation by organism of inflammatory response of other organism involved in symbiotic interaction
is_a: GO:0052261 ! suppression of defense response of other organism involved in symbiotic interaction

[Term]
id: GO:0052261
name: suppression of defense response of other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by organism of defense response of other organism during symbiotic interaction" RELATED []
synonym: "down-regulation by organism of defense response of other organism during symbiotic interaction" RELATED []
synonym: "downregulation by organism of defense response of other organism during symbiotic interaction" RELATED []
synonym: "inhibition by organism of defense response of other organism during symbiotic interaction" NARROW []
synonym: "negative regulation by organism of defense response of other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "negative regulation by organism of defense response of other organism involved in symbiotic interaction" EXACT []
synonym: "suppression of defense response of other organism" EXACT []
is_a: GO:0031348 ! negative regulation of defense response
is_a: GO:0051833 ! suppression of defenses of other organism involved in symbiotic interaction
is_a: GO:0052255 ! modulation by organism of defense response of other organism involved in symbiotic interaction

[Term]
id: GO:0052262
name: induction by organism of phytoalexin production in other organism involved in symbiotic interaction
namespace: biological_process
def: "The activation by an organism of the production of phytoalexins that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of phytoalexin production in other organism during symbiotic interaction" RELATED []
synonym: "induction by organism of phytoalexin production in other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0052329 ! positive regulation by organism of phytoalexin production in other organism involved in symbiotic interaction
is_a: GO:0052558 ! induction by organism of immune response of other organism involved in symbiotic interaction

[Term]
id: GO:0052263
name: induction by organism of defense-related nitric oxide production in other organism involved in symbiotic interaction
namespace: biological_process
def: "The activation by an organism of the production of nitric oxide that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of defense-related nitric oxide production in other organism" EXACT []
synonym: "activation by organism of defense-related NO production in other organism" EXACT []
synonym: "induction by organism of defense-related nitric oxide production in other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "induction by organism of defense-related NO production in other organism" EXACT []
is_a: GO:0052251 ! induction by organism of defense response of other organism involved in symbiotic interaction
is_a: GO:0052345 ! positive regulation by organism of defense-related nitric oxide production in other organism involved in symbiotic interaction
is_a: GO:0052558 ! induction by organism of immune response of other organism involved in symbiotic interaction

[Term]
id: GO:0052264
name: induction by organism of defense-related reactive oxygen species production in other organism involved in symbiotic interaction
namespace: biological_process
def: "The activation by an organism of the production of reactive oxygen species that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of defense-related active oxygen species production in other organism" EXACT []
synonym: "activation by organism of defense-related AOS production in other organism" EXACT []
synonym: "activation by organism of defense-related metabolic burst in other organism" EXACT []
synonym: "activation by organism of defense-related oxidative burst in other organism" EXACT []
synonym: "activation by organism of defense-related reactive oxidative species production in other organism" EXACT []
synonym: "activation by organism of defense-related reactive oxygen intermediate production in other organism" EXACT []
synonym: "activation by organism of defense-related reactive oxygen species production in other organism" EXACT []
synonym: "activation by organism of defense-related respiratory burst in other organism" EXACT []
synonym: "activation by organism of defense-related ROI production in other organism" EXACT []
synonym: "activation by organism of defense-related ROS production in other organism" EXACT []
synonym: "induction by organism of defense-related active oxygen species production in other organism" EXACT []
synonym: "induction by organism of defense-related AOS production in other organism" EXACT []
synonym: "induction by organism of defense-related metabolic burst in other organism" EXACT []
synonym: "induction by organism of defense-related oxidative burst in other organism" EXACT []
synonym: "induction by organism of defense-related reactive oxidative species production in other organism" EXACT []
synonym: "induction by organism of defense-related reactive oxygen intermediate production in other organism" EXACT []
synonym: "induction by organism of defense-related reactive oxygen species production in other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "induction by organism of defense-related respiratory burst in other organism" EXACT []
synonym: "induction by organism of defense-related ROI production in other organism" EXACT []
synonym: "induction by organism of defense-related ROS production in other organism" EXACT []
is_a: GO:0052251 ! induction by organism of defense response of other organism involved in symbiotic interaction
is_a: GO:0052348 ! positive regulation by organism of defense-related reactive oxygen species production in other organism involved in symbiotic interaction
is_a: GO:0052558 ! induction by organism of immune response of other organism involved in symbiotic interaction

[Term]
id: GO:0052265
name: induction by organism of defense-related calcium ion flux in other organism involved in symbiotic interaction
namespace: biological_process
def: "The activation by an organism of a flux of calcium ions that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of Ca2+ flux of other organism" EXACT []
synonym: "activation by organism of defense-related calcium ion flux in other organism during symbiotic interaction" RELATED []
synonym: "induction by organism of Ca2+ flux of other organism" EXACT []
synonym: "induction by organism of defense-related calcium ion flux in other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0052065 ! positive regulation by organism of defense-related calcium ion flux in other organism involved in symbiotic interaction
is_a: GO:0052251 ! induction by organism of defense response of other organism involved in symbiotic interaction

[Term]
id: GO:0052266
name: negative regulation by organism of jasmonic acid-mediated defense response of other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the jasmonic acid-mediated defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction" RELATED []
synonym: "down-regulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction" RELATED []
synonym: "downregulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction" RELATED []
synonym: "inhibition by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction" NARROW []
synonym: "negative regulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "suppression by organism of JA-mediated defense response of other organism" EXACT []
is_a: GO:0052261 ! suppression of defense response of other organism involved in symbiotic interaction
is_a: GO:0052283 ! modulation by organism of jasmonic acid-mediated defense response of other organism involved in symbiotic interaction

[Term]
id: GO:0052267
name: negative regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of jasmonic acid-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED []
synonym: "down-regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED []
synonym: "downregulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED []
synonym: "inhibition by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction" NARROW []
synonym: "negative regulation by organism of defense-related JA-mediated signal transduction pathway in other organism" EXACT []
synonym: "negative regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0052266 ! negative regulation by organism of jasmonic acid-mediated defense response of other organism involved in symbiotic interaction
is_a: GO:0052443 ! modulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction
is_a: GO:0052493 ! negative regulation by organism of signal transduction in other organism involved in symbiotic interaction

[Term]
id: GO:0052268
name: negative regulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of ethylene-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED []
synonym: "down-regulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED []
synonym: "downregulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED []
synonym: "inhibition by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction" NARROW []
synonym: "negative regulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0052254 ! negative regulation by organism of ethylene-mediated defense response of other organism involved in symbiotic interaction
is_a: GO:0052441 ! modulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism involved in symbiotic interaction
is_a: GO:0052493 ! negative regulation by organism of signal transduction in other organism involved in symbiotic interaction

[Term]
id: GO:0052269
name: positive regulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of ethylene-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of defense-related ethylene-mediated signal transduction pathway in other organism" NARROW []
synonym: "activation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction" NARROW []
synonym: "induction by organism of defense-related ethylene-mediated signal transduction pathway in other organism" NARROW []
synonym: "positive regulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "stimulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED []
synonym: "up-regulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED []
synonym: "upregulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism" NARROW []
synonym: "upregulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED []
is_a: GO:0052274 ! positive regulation by organism of ethylene-mediated defense response of other organism involved in symbiotic interaction
is_a: GO:0052441 ! modulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism involved in symbiotic interaction
is_a: GO:0052526 ! positive regulation by organism of signal transduction in other organism involved in symbiotic interaction

[Term]
id: GO:0052270
name: positive regulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of salicylic acid-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of defense-related SA-mediated signal transduction pathway in other organism" NARROW []
synonym: "activation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism" NARROW []
synonym: "activation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism during symbiotic interaction" NARROW []
synonym: "induction by organism of defense-related SA-mediated signal transduction pathway in other organism" NARROW []
synonym: "induction by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism" NARROW []
synonym: "positive regulation by organism of defense-related SA-mediated signal transduction pathway in other organism" NARROW []
synonym: "positive regulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "stimulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED []
synonym: "up-regulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED []
synonym: "upregulation by organism of defense-related SA-mediated signal transduction pathway in other organism" NARROW []
synonym: "upregulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism" NARROW []
synonym: "upregulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED []
is_a: GO:0052272 ! positive regulation by organism of salicylic acid-mediated defense response of other organism involved in symbiotic interaction
is_a: GO:0052445 ! modulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction
is_a: GO:0052526 ! positive regulation by organism of signal transduction in other organism involved in symbiotic interaction

[Term]
id: GO:0052271
name: positive regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of jasmonic acid-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism" NARROW []
synonym: "activation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction" NARROW []
synonym: "activation by organism of defense-related SA-mediated signal transduction pathway in other organism" NARROW []
synonym: "induction by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism" NARROW []
synonym: "induction by organism of defense-related SA-mediated signal transduction pathway in other organism" NARROW []
synonym: "positive regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "positive regulation by organism of defense-related SA-mediated signal transduction pathway in other organism" EXACT []
synonym: "stimulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED []
synonym: "up-regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED []
synonym: "upregulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism" NARROW []
synonym: "upregulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED []
synonym: "upregulation by organism of defense-related SA-mediated signal transduction pathway in other organism" NARROW []
is_a: GO:0052273 ! positive regulation by organism of jasmonic acid-mediated defense response of other organism involved in symbiotic interaction
is_a: GO:0052443 ! modulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction
is_a: GO:0052526 ! positive regulation by organism of signal transduction in other organism involved in symbiotic interaction

[Term]
id: GO:0052272
name: positive regulation by organism of salicylic acid-mediated defense response of other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the salicylic acid-mediated defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction" NARROW []
synonym: "induction by organism of SA-mediated defense response of other organism" NARROW []
synonym: "induction by organism of salicylic acid-mediated defense response of other organism" NARROW []
synonym: "positive regulation by organism of SA-mediated defense response of other organism" EXACT []
synonym: "positive regulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "stimulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction" RELATED []
synonym: "up-regulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction" RELATED []
synonym: "upregulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction" RELATED []
is_a: GO:0052284 ! modulation by organism of salicylic acid-mediated defense response of other organism involved in symbiotic interaction
is_a: GO:0052510 ! positive regulation by organism of defense response of other organism involved in symbiotic interaction

[Term]
id: GO:0052273
name: positive regulation by organism of jasmonic acid-mediated defense response of other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the jasmonic acid-mediated defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction" NARROW []
synonym: "induction by organism of JA-mediated defense response of other organism" NARROW []
synonym: "induction by organism of jasmonic acid-mediated defense response of other organism" NARROW []
synonym: "positive regulation by organism of JA-mediated defense response of other organism" EXACT []
synonym: "positive regulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "stimulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction" RELATED []
synonym: "up-regulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction" RELATED []
synonym: "upregulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction" RELATED []
is_a: GO:0052283 ! modulation by organism of jasmonic acid-mediated defense response of other organism involved in symbiotic interaction
is_a: GO:0052510 ! positive regulation by organism of defense response of other organism involved in symbiotic interaction

[Term]
id: GO:0052274
name: positive regulation by organism of ethylene-mediated defense response of other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the ethylene-mediated defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of ethylene-mediated defense response of other organism" NARROW []
synonym: "activation by organism of ethylene-mediated defense response of other organism during symbiotic interaction" NARROW []
synonym: "induction by organism of ethylene-mediated defense response of other organism" NARROW []
synonym: "positive regulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "stimulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction" RELATED []
synonym: "up-regulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction" RELATED []
synonym: "upregulation by organism of ethylene-mediated defense response of other organism" NARROW []
synonym: "upregulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction" RELATED []
is_a: GO:0052279 ! modulation by organism of ethylene-mediated defense response of other organism involved in symbiotic interaction
is_a: GO:0052510 ! positive regulation by organism of defense response of other organism involved in symbiotic interaction

[Term]
id: GO:0052275
name: negative regulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of MAP kinase-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED []
synonym: "down-regulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED []
synonym: "downregulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED []
synonym: "inhibition by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction" NARROW []
synonym: "negative regulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "negative regulation by organism of defense-related MAPK-mediated signal transduction pathway in other organism" EXACT []
synonym: "negative regulation by organism of defense-related mitogen-activated protein kinase-mediated signal transduction pathway in other organism" EXACT []
is_a: GO:0052261 ! suppression of defense response of other organism involved in symbiotic interaction

[Term]
id: GO:0052276
name: positive regulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of MAP kinase-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of defense-related ethylene-mediated signal transduction pathway in other organism" NARROW []
synonym: "activation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction" NARROW []
synonym: "induction by organism of defense-related ethylene-mediated signal transduction pathway in other organism" NARROW []
synonym: "positive regulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "positive regulation by organism of defense-related MAPK-mediated signal transduction pathway in other organism" EXACT []
synonym: "positive regulation by organism of defense-related mitogen-activated protein kinase-mediated signal transduction pathway in other organism" EXACT []
synonym: "stimulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED []
synonym: "up-regulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED []
synonym: "upregulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism" NARROW []
synonym: "upregulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED []
is_a: GO:0052277 ! modulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism involved in symbiotic interaction
is_a: GO:0052510 ! positive regulation by organism of defense response of other organism involved in symbiotic interaction
is_a: GO:0052526 ! positive regulation by organism of signal transduction in other organism involved in symbiotic interaction

[Term]
id: GO:0052277
name: modulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of MAP kinase-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "modulation of defense-related MAPK-mediated signal transduction pathway of other organism" EXACT []
synonym: "modulation of defense-related mitogen activated protein kinase-mediated signal transduction pathway of other organism" EXACT []
is_a: GO:0052250 ! modulation of signal transduction in other organism involved in symbiotic interaction
is_a: GO:0052255 ! modulation by organism of defense response of other organism involved in symbiotic interaction

[Term]
id: GO:0052278
name: negative regulation by organism of cell-mediated immune response of other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the cell-based immune response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by organism of cell-mediated immune response of other organism during symbiotic interaction" RELATED []
synonym: "down-regulation by organism of cell-mediated immune response of other organism during symbiotic interaction" RELATED []
synonym: "downregulation by organism of cell-mediated immune response of other organism during symbiotic interaction" RELATED []
synonym: "inhibition by organism of cell-mediated immune response of other organism during symbiotic interaction" NARROW []
synonym: "negative regulation by organism of cell-based immune response of other organism during symbiotic interaction" RELATED []
synonym: "negative regulation by organism of cell-mediated immune response of other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0052294 ! modulation by organism of cell-mediated immune response of other organism involved in symbiotic interaction
is_a: GO:0052561 ! negative regulation by organism of immune response of other organism involved in symbiotic interaction

[Term]
id: GO:0052279
name: modulation by organism of ethylene-mediated defense response of other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of the ethylene-mediated defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0052255 ! modulation by organism of defense response of other organism involved in symbiotic interaction

[Term]
id: GO:0052280
name: negative regulation by organism of T-cell mediated immune response of other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the T-cell mediated immune response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by organism of T-cell mediated immune response of other organism during symbiotic interaction" RELATED []
synonym: "down-regulation by organism of T-cell mediated immune response of other organism during symbiotic interaction" RELATED []
synonym: "downregulation by organism of T-cell mediated immune response of other organism during symbiotic interaction" RELATED []
synonym: "inhibition by organism of T-cell mediated immune response of other organism during symbiotic interaction" NARROW []
synonym: "negative regulation by organism of T-cell mediated immune response of other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0052278 ! negative regulation by organism of cell-mediated immune response of other organism involved in symbiotic interaction
is_a: GO:0052295 ! modulation by organism of T-cell mediated immune response of other organism involved in symbiotic interaction

[Term]
id: GO:0052281
name: negative regulation by organism of B-cell mediated immune response of other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the B-cell mediated immune response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by organism of B-cell mediated immune response of other organism during symbiotic interaction" RELATED []
synonym: "down-regulation by organism of B-cell mediated immune response of other organism during symbiotic interaction" RELATED []
synonym: "downregulation by organism of B-cell mediated immune response of other organism during symbiotic interaction" RELATED []
synonym: "inhibition by organism of B-cell mediated immune response of other organism during symbiotic interaction" NARROW []
synonym: "negative regulation by organism of B-cell mediated immune response of other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0052293 ! modulation by organism of B-cell mediated immune response of other organism involved in symbiotic interaction
is_a: GO:0052561 ! negative regulation by organism of immune response of other organism involved in symbiotic interaction

[Term]
id: GO:0052282
name: negative regulation by organism of defense-related callose deposition in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the accumulation of callose that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by organism of defense-related callose deposition in other organism during symbiotic interaction" RELATED []
synonym: "down-regulation by organism of defense-related callose deposition in other organism during symbiotic interaction" RELATED []
synonym: "downregulation by organism of defense-related callose deposition in other organism during symbiotic interaction" RELATED []
synonym: "inhibition by organism of defense-related callose deposition in other organism during symbiotic interaction" NARROW []
synonym: "negative regulation by organism of defense-related callose deposition in other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "suppression by organism of defense-related callose deposition of other organism" EXACT []
is_a: GO:0052261 ! suppression of defense response of other organism involved in symbiotic interaction
is_a: GO:0052285 ! modulation by organism of defense-related callose deposition of other organism involved in symbiotic interaction

[Term]
id: GO:0052283
name: modulation by organism of jasmonic acid-mediated defense response of other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of the jasmonic acid-mediated defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of JA-mediated defense response of other organism" EXACT []
synonym: "modulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0052552 ! modulation by organism of immune response of other organism involved in symbiotic interaction

[Term]
id: GO:0052284
name: modulation by organism of salicylic acid-mediated defense response of other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of the salicylic acid-mediated defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of SA-mediated defense response of other organism" EXACT []
synonym: "modulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction" RELATED [GOC:tb]
is_a: GO:0052255 ! modulation by organism of defense response of other organism involved in symbiotic interaction

[Term]
id: GO:0052285
name: modulation by organism of defense-related callose deposition of other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of the accumulation of callose that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of defense-related callose deposition of other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0052255 ! modulation by organism of defense response of other organism involved in symbiotic interaction

[Term]
id: GO:0052286
name: induction by organism of resistance gene-dependent defense response of other organism involved in symbiotic interaction
namespace: biological_process
def: "The activation by an organism of the resistance gene-dependent defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of defense response of other organism by specific elicitors" EXACT []
synonym: "activation by organism of gene-for-gene resistance in other organism" EXACT []
synonym: "activation by organism of resistance gene-dependent defense response of other organism" EXACT []
synonym: "induction by organism of defense response of other organism by specific elicitors" EXACT []
synonym: "induction by organism of gene-for-gene resistance in other organism" EXACT []
synonym: "induction by organism of resistance gene-dependent defense response of other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0052423 ! positive regulation by organism of resistance gene-dependent defense response of other organism involved in symbiotic interaction
is_a: GO:0052558 ! induction by organism of immune response of other organism involved in symbiotic interaction

[Term]
id: GO:0052287
name: positive regulation by organism of defense-related calcium-dependent protein kinase pathway in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of calcium-dependent protein kinase pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of defense-related calcium-dependent protein kinase pathway in other organism during symbiotic interaction" NARROW []
synonym: "positive regulation by organism of defense-related calcium-dependent protein kinase pathway in other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "positive regulation by organism of defense-related CDPK pathway of other organism" RELATED []
synonym: "stimulation by organism of defense-related calcium-dependent protein kinase pathway in other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of defense-related calcium-dependent protein kinase pathway in other organism during symbiotic interaction" RELATED []
synonym: "up-regulation by organism of defense-related calcium-dependent protein kinase pathway in other organism during symbiotic interaction" RELATED []
synonym: "upregulation by organism of defense-related calcium-dependent protein kinase pathway in other organism during symbiotic interaction" RELATED []
is_a: GO:0050850 ! positive regulation of calcium-mediated signaling
is_a: GO:0052307 ! modulation by organism of defense-related calcium-dependent protein kinase pathway in other organism involved in symbiotic interaction
is_a: GO:0052510 ! positive regulation by organism of defense response of other organism involved in symbiotic interaction

[Term]
id: GO:0052288
name: induction by organism of induced systemic resistance in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism activates induced systemic resistance, a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling, in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of induced systemic resistance in other organism during symbiotic interaction" RELATED []
synonym: "activation by organism of ISR in other organism" EXACT []
synonym: "induction by organism of induced systemic resistance in other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "induction by organism of ISR in other organism" EXACT []
is_a: GO:0052382 ! induction by organism of innate immune response in other organism involved in symbiotic interaction
is_a: GO:0052532 ! positive regulation by organism of induced systemic resistance in other organism involved in symbiotic interaction

[Term]
id: GO:0052289
name: induction by organism of systemic acquired resistance in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism activates systemic acquired resistance, a salicylic acid-mediated response that confers broad spectrum systemic resistance, in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of SAR in other organism" EXACT []
synonym: "activation by organism of systemic acquired resistance in other organism" EXACT []
synonym: "induction by organism of SAR in other organism" EXACT []
synonym: "induction by organism of systemic acquired resistance in other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0052382 ! induction by organism of innate immune response in other organism involved in symbiotic interaction
is_a: GO:0052535 ! positive regulation by organism of systemic acquired resistance in other organism involved in symbiotic interaction

[Term]
id: GO:0052290
name: induction by organism of defense-related cell wall thickening in other organism involved in symbiotic interaction
namespace: biological_process
def: "The activation by an organism of the thickening of cell walls that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of defense-related cell wall thickening in other organism during symbiotic interaction" RELATED []
synonym: "activation by organism of defensive cell wall thickening in other organism during symbiotic interaction" RELATED []
synonym: "induction by organism of defense-related cell wall thickening in other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "induction by organism of defensive cell wall thickening in other organism during symbiotic interaction" RELATED []
is_a: GO:0052251 ! induction by organism of defense response of other organism involved in symbiotic interaction
is_a: GO:0052538 ! positive regulation by organism of defense-related cell wall thickening in other organism involved in symbiotic interaction

[Term]
id: GO:0052291
name: positive regulation by organism of defense-related callose deposition in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the accumulation of callose that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of defense-related callose deposition in other organism during symbiotic interaction" NARROW []
synonym: "induction by organism of defense-related callose deposition of other organism" NARROW []
synonym: "induction by organism of defense-related papilla formation in other organism" NARROW []
synonym: "positive regulation by organism of defense-related callose deposition in other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "positive regulation by organism of defense-related papilla formation in other organism" EXACT []
synonym: "stimulation by organism of defense-related callose deposition in other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of defense-related callose deposition in other organism during symbiotic interaction" EXACT []
synonym: "up-regulation by organism of defense-related callose deposition in other organism during symbiotic interaction" EXACT []
synonym: "upregulation by organism of defense-related callose deposition in other organism during symbiotic interaction" EXACT []
is_a: GO:0052285 ! modulation by organism of defense-related callose deposition of other organism involved in symbiotic interaction
is_a: GO:0052510 ! positive regulation by organism of defense response of other organism involved in symbiotic interaction

[Term]
id: GO:0052292
name: positive regulation by organism of defense-related cell wall callose deposition in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the deposition by a second organism of callose in its cell walls, occurring as part of the defense response, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction" NARROW []
synonym: "induction by organism of defense-related cell wall callose deposition in other organism" NARROW []
synonym: "positive regulation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "stimulation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction" RELATED []
synonym: "up-regulation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction" RELATED []
synonym: "upregulation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction" RELATED []
is_a: GO:0052291 ! positive regulation by organism of defense-related callose deposition in other organism involved in symbiotic interaction
is_a: GO:0052310 ! modulation by organism of defense-related cell wall callose deposition in other organism involved in symbiotic interaction
is_a: GO:0052538 ! positive regulation by organism of defense-related cell wall thickening in other organism involved in symbiotic interaction

[Term]
id: GO:0052293
name: modulation by organism of B-cell mediated immune response of other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of the B-cell mediated immune response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of B-cell mediated immune response of other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "regulation by organism of B-cell mediated immune response of other organism" EXACT []
is_a: GO:0052552 ! modulation by organism of immune response of other organism involved in symbiotic interaction

[Term]
id: GO:0052294
name: modulation by organism of cell-mediated immune response of other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of any form of cell-based immune response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of cell-based immune response of other organism during symbiotic interaction" RELATED []
synonym: "modulation by organism of cell-mediated immune response of other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0052552 ! modulation by organism of immune response of other organism involved in symbiotic interaction

[Term]
id: GO:0052295
name: modulation by organism of T-cell mediated immune response of other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of the T-cell mediated immune response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "modulation by organism of T-cell mediated immune response of other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0052294 ! modulation by organism of cell-mediated immune response of other organism involved in symbiotic interaction

[Term]
id: GO:0052296
name: modulation by organism of microbe-associated molecular pattern-induced innate immune response in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process that involves recognition of a microbe-associated molecular pattern, and by which an organism modulates the frequency, rate or extent of the innate immune response, the first line of defense against infection, of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mah]
synonym: "modulation by organism of microbe-associated molecular pattern-induced innate immunity in other organism involved in symbiotic interaction" EXACT [GOC:pg]
synonym: "modulation by organism of pathogen-associated molecular pattern-induced innate immunity in other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "modulation by organism of pathogen-associated molecular pattern-induced innate immunity in other organism involved in symbiotic interaction" NARROW []
is_a: GO:0052306 ! modulation by organism of innate immune response in other organism involved in symbiotic interaction

[Term]
id: GO:0052297
name: modulation by organism of resistance gene-dependent defense response of other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of the resistance gene-dependent defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of defense response in other organism by specific elicitors" EXACT []
synonym: "modulation by organism of gene-for-gene resistance in other organism" EXACT []
synonym: "modulation by organism of resistance gene-dependent defense response of other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0052552 ! modulation by organism of immune response of other organism involved in symbiotic interaction

[Term]
id: GO:0052298
name: modulation by organism of induced systemic resistance in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of induced systemic resistance, a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling, in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of induced systemic resistance in other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0045088 ! regulation of innate immune response
is_a: GO:0052306 ! modulation by organism of innate immune response in other organism involved in symbiotic interaction

[Term]
id: GO:0052299
name: modulation by organism of systemic acquired resistance in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of systemic acquired resistance, a salicylic acid-mediated response that confers broad spectrum systemic resistance, in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of systemic acquired resistance in other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0010112 ! regulation of systemic acquired resistance
is_a: GO:0052552 ! modulation by organism of immune response of other organism involved in symbiotic interaction

[Term]
id: GO:0052300
name: modulation by organism of defense-related cell wall thickening in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of the thickening of cell walls that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of defense-related cell wall thickening in other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "modulation by organism of defensive cell wall thickening in other organism during symbiotic interaction" RELATED []
is_a: GO:0052255 ! modulation by organism of defense response of other organism involved in symbiotic interaction

[Term]
id: GO:0052301
name: modulation by organism of defense-related calcium ion flux in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of fluxes of calcium ions that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of defense-related Ca2+ flux in other organism during symbiotic interaction" EXACT []
synonym: "modulation by organism of defense-related calcium ion flux in other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0050848 ! regulation of calcium-mediated signaling
is_a: GO:0052255 ! modulation by organism of defense response of other organism involved in symbiotic interaction

[Term]
id: GO:0052302
name: modulation by organism of defense-related nitric oxide production in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of the production of nitric oxide that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of defense-related nitric oxide production in other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "modulation by organism of defense-related NO production in other organism during symbiotic interaction" RELATED []
is_a: GO:0052551 ! response to defense-related nitric oxide production by other organism involved in symbiotic interaction
is_a: GO:0052552 ! modulation by organism of immune response of other organism involved in symbiotic interaction

[Term]
id: GO:0052303
name: modulation by organism of defense-related reactive oxygen species production in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of the production of reactive oxygen species that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of defense-related active oxygen species production in other organism" EXACT []
synonym: "modulation by organism of defense-related AOS production in other organism" EXACT []
synonym: "modulation by organism of defense-related metabolic burst in other organism" EXACT []
synonym: "modulation by organism of defense-related oxidative burst in other organism" EXACT []
synonym: "modulation by organism of defense-related reactive oxidative species production in other organism" EXACT []
synonym: "modulation by organism of defense-related reactive oxygen intermediate production in other organism" EXACT []
synonym: "modulation by organism of defense-related reactive oxygen species production in other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "modulation by organism of defense-related respiratory burst in other organism" EXACT []
synonym: "modulation by organism of defense-related ROI production in other organism" EXACT []
synonym: "modulation by organism of defense-related ROS production in other organism" EXACT []
is_a: GO:0052550 ! response to defense-related reactive oxygen species production by other organism involved in symbiotic interaction
is_a: GO:0052552 ! modulation by organism of immune response of other organism involved in symbiotic interaction

[Term]
id: GO:0052304
name: modulation by organism of phytoalexin production in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of production of phytoalexins that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of phytoalexin production in other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0052549 ! response to phytoalexin production by other organism involved in symbiotic interaction
is_a: GO:0052552 ! modulation by organism of immune response of other organism involved in symbiotic interaction

[Term]
id: GO:0052305
name: positive regulation by organism of innate immune response in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the innate immune response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of innate immunity in other organism during symbiotic interaction" NARROW []
synonym: "positive regulation by organism of innate immunity in other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "positive regulation by organism of innate immunity in other organism involved in symbiotic interaction" EXACT [GOC:pg]
synonym: "positive regulation of innate immune response of other organism" EXACT []
synonym: "stimulation by organism of innate immunity in other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of innate immunity in other organism during symbiotic interaction" RELATED []
synonym: "up-regulation by organism of innate immunity in other organism during symbiotic interaction" RELATED []
synonym: "upregulation by organism of innate immunity in other organism during symbiotic interaction" RELATED []
is_a: GO:0045089 ! positive regulation of innate immune response
is_a: GO:0052306 ! modulation by organism of innate immune response in other organism involved in symbiotic interaction
is_a: GO:0052510 ! positive regulation by organism of defense response of other organism involved in symbiotic interaction
is_a: GO:0052555 ! positive regulation by organism of immune response of other organism involved in symbiotic interaction

[Term]
id: GO:0052306
name: modulation by organism of innate immune response in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of the innate immune response, the first line of defense against infection, of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of innate immunity in other organism involved in symbiotic interaction" EXACT [GOC:dph, GOC:pg]
synonym: "modulation of innate immune response of other organism" EXACT []
is_a: GO:0052552 ! modulation by organism of immune response of other organism involved in symbiotic interaction

[Term]
id: GO:0052307
name: modulation by organism of defense-related calcium-dependent protein kinase pathway in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of calcium-dependent protein kinase signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of defense-related calcium-dependent protein kinase pathway in other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "modulation by organism of defense-related CDPK pathway in other organism during symbiotic interaction" EXACT []
is_a: GO:0050848 ! regulation of calcium-mediated signaling
is_a: GO:0052255 ! modulation by organism of defense response of other organism involved in symbiotic interaction

[Term]
id: GO:0052308
name: pathogen-associated molecular pattern dependent modulation by organism of innate immune response in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process that involves recognition of a pathogen-associated molecular pattern, and by which an organism modulates the frequency, rate or extent of the innate immune response, the first line of defense against infection, of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mah]
synonym: "pathogen-associated molecular pattern dependent modulation by organism of innate immunity in other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "pathogen-associated molecular pattern dependent modulation by organism of innate immunity in other organism involved in symbiotic interaction" EXACT [GOC:pg]
is_a: GO:0052306 ! modulation by organism of innate immune response in other organism involved in symbiotic interaction

[Term]
id: GO:0052309
name: negative regulation by organism of innate immune response in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the innate immune response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by organism of innate immunity in other organism during symbiotic interaction" RELATED []
synonym: "down-regulation by organism of innate immunity in other organism during symbiotic interaction" RELATED []
synonym: "downregulation by organism of innate immunity in other organism during symbiotic interaction" RELATED []
synonym: "inhibition by organism of innate immunity in other organism during symbiotic interaction" NARROW []
synonym: "negative regulation by organism of innate immunity in other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "negative regulation of innate immune response of other organism" EXACT []
is_a: GO:0045824 ! negative regulation of innate immune response
is_a: GO:0052261 ! suppression of defense response of other organism involved in symbiotic interaction
is_a: GO:0052306 ! modulation by organism of innate immune response in other organism involved in symbiotic interaction
is_a: GO:0052561 ! negative regulation by organism of immune response of other organism involved in symbiotic interaction

[Term]
id: GO:0052310
name: modulation by organism of defense-related cell wall callose deposition in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of the accumulation of callose in cell walls that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0052285 ! modulation by organism of defense-related callose deposition of other organism involved in symbiotic interaction
is_a: GO:0052300 ! modulation by organism of defense-related cell wall thickening in other organism involved in symbiotic interaction

[Term]
id: GO:0052311
name: negative regulation by organism of defense-related cell wall callose deposition in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the accumulation of callose in cell walls that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction" RELATED []
synonym: "down-regulation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction" RELATED []
synonym: "downregulation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction" RELATED []
synonym: "inhibition by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction" NARROW []
synonym: "negative regulation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0052282 ! negative regulation by organism of defense-related callose deposition in other organism involved in symbiotic interaction
is_a: GO:0052310 ! modulation by organism of defense-related cell wall callose deposition in other organism involved in symbiotic interaction

[Term]
id: GO:0052312
name: modulation of transcription in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of transcription in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation of transcription in other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0051817 ! modification of morphology or physiology of other organism involved in symbiotic interaction
is_a: GO:2001141 ! regulation of RNA biosynthetic process

[Term]
id: GO:0052313
name: modulation of nutrient release from other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of the release of nutrients from a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation of nutrient release from other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0051817 ! modification of morphology or physiology of other organism involved in symbiotic interaction
relationship: part_of GO:0051816 ! acquisition of nutrients from other organism during symbiotic interaction

[Term]
id: GO:0052314
name: phytoalexin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phytoalexins, any of a range of substances produced by plants as part of their defense response." [Wikipedia:Phytoalexin]
subset: goslim_pir
subset: gosubset_prok
synonym: "phytoalexin metabolism" EXACT []
is_a: GO:0009404 ! toxin metabolic process

[Term]
id: GO:0052315
name: phytoalexin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phytoalexins, any of a range of substances produced by plants as part of their defense response." [Wikipedia:Phytoalexin]
synonym: "phytoalexin biosynthesis" EXACT []
is_a: GO:0009403 ! toxin biosynthetic process
is_a: GO:0052314 ! phytoalexin metabolic process

[Term]
id: GO:0052316
name: phytoalexin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phytoalexins, any of a range of substances produced by plants as part of their defense response." [GOC:ai]
synonym: "phytoalexin catabolism" EXACT []
is_a: GO:0009407 ! toxin catabolic process
is_a: GO:0052314 ! phytoalexin metabolic process

[Term]
id: GO:0052317
name: camalexin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving camalexin, an indole phytoalexin." [GOC:ai]
synonym: "camalexin metabolism" EXACT []
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0046217 ! indole phytoalexin metabolic process

[Term]
id: GO:0052318
name: regulation of phytoalexin metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phytoalexin metabolism, the chemical reactions and pathways involving phytoalexins, any of a range of substances produced by plants as part of their defense response." [GOC:ai]
synonym: "regulation of phytoalexin metabolism" EXACT []
is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:0043455 ! regulation of secondary metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0052314 ! phytoalexin metabolic process
relationship: regulates GO:0052314 ! phytoalexin metabolic process

[Term]
id: GO:0052319
name: regulation of phytoalexin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phytoalexin biosynthesis, the chemical reactions and pathways resulting in the formation of phytoalexins." [GOC:ai]
synonym: "regulation of phytoalexin biosynthesis" EXACT []
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0052318 ! regulation of phytoalexin metabolic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0052315 ! phytoalexin biosynthetic process
relationship: regulates GO:0052315 ! phytoalexin biosynthetic process

[Term]
id: GO:0052320
name: positive regulation of phytoalexin metabolic process
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of phytoalexin metabolism, the chemical reactions and pathways involving phytoalexins." [GOC:mtg_pamgo_17jul06]
synonym: "activation of phytoalexin metabolism" NARROW []
synonym: "positive regulation of phytoalexin metabolism" RELATED []
synonym: "stimulation of phytoalexin metabolism" NARROW []
synonym: "up regulation of phytoalexin metabolism" EXACT []
synonym: "up-regulation of phytoalexin metabolism" EXACT []
synonym: "upregulation of phytoalexin metabolism" EXACT []
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0052318 ! regulation of phytoalexin metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0052314 ! phytoalexin metabolic process
relationship: positively_regulates GO:0052314 ! phytoalexin metabolic process

[Term]
id: GO:0052321
name: negative regulation of phytoalexin metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of phytoalexin metabolism, the chemical reactions and pathways involving phytoalexins." [GOC:ai]
synonym: "down regulation of phytoalexin metabolism" EXACT []
synonym: "down-regulation of phytoalexin metabolism" EXACT []
synonym: "downregulation of phytoalexin metabolism" EXACT []
synonym: "inhibition of phytoalexin metabolism" NARROW []
synonym: "negative regulation of phytoalexin metabolism" EXACT []
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0052318 ! regulation of phytoalexin metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0052314 ! phytoalexin metabolic process
relationship: negatively_regulates GO:0052314 ! phytoalexin metabolic process

[Term]
id: GO:0052322
name: positive regulation of phytoalexin biosynthetic process
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of phytoalexin biosynthesis, the chemical reactions and pathways resulting in the formation of phytoalexins." [GOC:mtg_pamgo_17jul06]
synonym: "activation of phytoalexin biosynthesis" NARROW []
synonym: "positive regulation of phytoalexin biosynthesis" EXACT []
synonym: "stimulation of phytoalexin biosynthesis" NARROW []
synonym: "up regulation of phytoalexin biosynthesis" EXACT []
synonym: "up-regulation of phytoalexin biosynthesis" EXACT []
synonym: "upregulation of phytoalexin biosynthesis" EXACT []
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0052319 ! regulation of phytoalexin biosynthetic process
is_a: GO:0052320 ! positive regulation of phytoalexin metabolic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0052315 ! phytoalexin biosynthetic process
relationship: positively_regulates GO:0052315 ! phytoalexin biosynthetic process

[Term]
id: GO:0052323
name: negative regulation of phytoalexin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of phytoalexin biosynthesis, the chemical reactions and pathways resulting in the formation of phytoalexins." [GOC:ai]
synonym: "down regulation of phytoalexin biosynthesis" EXACT []
synonym: "down-regulation of phytoalexin biosynthesis" EXACT []
synonym: "downregulation of phytoalexin biosynthesis" EXACT []
synonym: "inhibition of phytoalexin biosynthesis" NARROW []
synonym: "negative regulation of phytoalexin biosynthesis" EXACT []
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0052319 ! regulation of phytoalexin biosynthetic process
is_a: GO:0052321 ! negative regulation of phytoalexin metabolic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0052315 ! phytoalexin biosynthetic process
relationship: negatively_regulates GO:0052315 ! phytoalexin biosynthetic process

[Term]
id: GO:0052324
name: plant-type cell wall cellulose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, as part of the organization and biogenesis of the cell wall." [GOC:ai]
synonym: "cell wall cellulose biosynthesis" EXACT []
synonym: "cellulose biosynthesis during cell wall biosynthesis" RELATED []
is_a: GO:0030244 ! cellulose biosynthetic process
is_a: GO:0052541 ! plant-type cell wall cellulose metabolic process
is_a: GO:0070592 ! cell wall polysaccharide biosynthetic process
relationship: part_of GO:0009832 ! plant-type cell wall biogenesis

[Term]
id: GO:0052325
name: cell wall pectin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues, as part of the organization and biogenesis of the cell wall." [GOC:ai]
synonym: "cell wall pectin biosynthesis" EXACT []
synonym: "pectin biosynthesis during cell wall organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0045489 ! pectin biosynthetic process
is_a: GO:0052546 ! cell wall pectin metabolic process
is_a: GO:0070592 ! cell wall polysaccharide biosynthetic process
relationship: part_of GO:0009832 ! plant-type cell wall biogenesis
relationship: part_of GO:0071555 ! cell wall organization

[Term]
id: GO:0052326
name: obsolete interaction with symbiont via protein secreted by type IV secretion system
namespace: biological_process
def: "OBSOLETE. An interaction with the symbiont organism mediated by a substance secreted by the other organism by a type IV secretion system. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "interaction with symbiont via protein secreted by type IV secretion system" EXACT []
is_obsolete: true

[Term]
id: GO:0052327
name: obsolete interaction with symbiont via protein secreted by type II secretion system
namespace: biological_process
def: "OBSOLETE. An interaction with the symbiont organism mediated by a substance secreted by the other organism by a type II secretion system. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "interaction with symbiont via protein secreted by type II secretion system" EXACT []
is_obsolete: true

[Term]
id: GO:0052328
name: obsolete interaction with symbiont via protein secreted by type III secretion system
namespace: biological_process
def: "OBSOLETE. An interaction with the symbiont organism mediated by a substance secreted by the other organism by a type III secretion system. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "interaction with symbiont via protein secreted by type III secretion system" EXACT []
is_obsolete: true

[Term]
id: GO:0052329
name: positive regulation by organism of phytoalexin production in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the production of phytoalexins that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of phytoalexin production in other organism during symbiotic interaction" NARROW []
synonym: "positive regulation by organism of phytoalexin production in other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "stimulation by organism of phytoalexin production in other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of phytoalexin production in other organism during symbiotic interaction" RELATED []
synonym: "up-regulation by organism of phytoalexin production in other organism during symbiotic interaction" RELATED []
synonym: "upregulation by organism of phytoalexin production in other organism during symbiotic interaction" RELATED []
is_a: GO:0052304 ! modulation by organism of phytoalexin production in other organism involved in symbiotic interaction
is_a: GO:0052555 ! positive regulation by organism of immune response of other organism involved in symbiotic interaction

[Term]
id: GO:0052330
name: positive regulation by organism of programmed cell death in other organism involved in symbiotic interaction
namespace: biological_process
alt_id: GO:0052518
alt_id: GO:0052529
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in a second organism, where the two organisms are in a symbiotic interaction." [GOC:jl, GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of programmed cell death in other organism during symbiotic interaction" NARROW []
synonym: "enhancement of other organism programmed cell death by organism" RELATED []
synonym: "positive regulation by organism of non-apoptotic programmed cell death in other organism during symbiotic interaction" NARROW []
synonym: "positive regulation by organism of programmed cell death in other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "stimulation by organism of programmed cell death in other organism during symbiotic interaction" NARROW []
synonym: "upregulation by organism of programmed cell death in other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "upregulation by organism of programmed cell death in other organism involved in symbiotic interaction" EXACT []
is_a: GO:0043068 ! positive regulation of programmed cell death
is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism
is_a: GO:0051712 ! positive regulation of killing of cells of other organism
is_a: GO:0052248 ! modulation of programmed cell death in other organism involved in symbiotic interaction
relationship: positively_regulates GO:0051883 ! killing of cells in other organism involved in symbiotic interaction

[Term]
id: GO:0052331
name: hemolysis in other organism involved in symbiotic interaction
namespace: biological_process
def: "The cytolytic destruction of red blood cells, with the release of intracellular hemoglobin, in one organism by another, where two organisms are in a symbiotic interaction." [GOC:add, UniProtKB-KW:KW-0354]
subset: gosubset_prok
synonym: "haemolysis in other organism involved in symbiotic interaction" EXACT []
synonym: "hemolysin activity" RELATED []
synonym: "hemolysis by organism of erythrocytes in other organism during symbiotic interaction" RELATED []
synonym: "hemolysis by organism of RBCs in other organism during symbiotic interaction" RELATED [CL:0000232]
synonym: "hemolysis by organism of red blood cells in other organism during symbiotic interaction" RELATED [CL:0000232]
synonym: "hemolysis of cells in other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "hemolysis of cells in other organism involved in symbiotic interaction" EXACT [GOC:bf]
is_a: GO:0044179 ! hemolysis in other organism
is_a: GO:0051801 ! cytolysis in other organism involved in symbiotic interaction
intersection_of: GO:0044179 ! hemolysis in other organism
intersection_of: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism
relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism

[Term]
id: GO:0052332
name: modification by organism of membrane in other organism involved in symbiotic interaction
namespace: biological_process
def: "The process in which an organism effects a change in the structure or function of a cellular membrane of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modification by organism of cell membrane in other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "modification by organism of cell membrane in other organism involved in symbiotic interaction" NARROW [GOC:bf, GOC:jl]
is_a: GO:0052188 ! modification of cellular component in other organism involved in symbiotic interaction

[Term]
id: GO:0052333
name: modification by organism of cell wall of other organism involved in symbiotic interaction
namespace: biological_process
def: "The process in which an organism effects a change in the structure or function of the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "metabolism by organism of cell wall of other organism" RELATED []
synonym: "modification by organism of cell wall of other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0052188 ! modification of cellular component in other organism involved in symbiotic interaction

[Term]
id: GO:0052334
name: modification by organism of cytoskeleton of other organism involved in symbiotic interaction
namespace: biological_process
def: "The process in which an organism effects a change in the structure or function of the cytoskeleton of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modification by organism of cytoskeleton of other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0052188 ! modification of cellular component in other organism involved in symbiotic interaction

[Term]
id: GO:0052335
name: modification by host of symbiont cytoskeleton
namespace: biological_process
def: "The process in which an organism effects a change in the structure or function of the symbiont cytoskeleton. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0052187 ! modification by host of symbiont cellular component
is_a: GO:0052334 ! modification by organism of cytoskeleton of other organism involved in symbiotic interaction

[Term]
id: GO:0052336
name: modification by host of symbiont cell wall
namespace: biological_process
def: "The process in which an organism effects a change in the structure or function of the symbiont cell wall. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
synonym: "metabolism of symbiont cell wall by organism" EXACT []
is_a: GO:0052187 ! modification by host of symbiont cellular component
is_a: GO:0052333 ! modification by organism of cell wall of other organism involved in symbiotic interaction

[Term]
id: GO:0052337
name: modification by host of symbiont membrane
namespace: biological_process
def: "The process in which an organism effects a change in the structure or function of a symbiont cellular membrane. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "modification by host of symbiont cell membrane" NARROW [GOC:bf, GOC:jl]
is_a: GO:0052187 ! modification by host of symbiont cellular component
is_a: GO:0052332 ! modification by organism of membrane in other organism involved in symbiotic interaction

[Term]
id: GO:0052338
name: disruption by host of symbiont cell wall
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of the symbiont cell wall. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
synonym: "catabolism of symbiont cell wall by organism" EXACT []
synonym: "degradation of symbiont cell wall by organism" EXACT []
synonym: "disassembly by host of symbiont cell wall" EXACT []
is_a: GO:0052336 ! modification by host of symbiont cell wall
is_a: GO:0052339 ! disruption by organism of cell wall of other organism involved in symbiotic interaction
is_a: GO:0052367 ! disruption by host of symbiont cellular component

[Term]
id: GO:0052339
name: disruption by organism of cell wall of other organism involved in symbiotic interaction
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "disassembly by organism of cell wall of other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0052333 ! modification by organism of cell wall of other organism involved in symbiotic interaction

[Term]
id: GO:0052340
name: catabolism by organism of cell wall cellulose in other organism involved in symbiotic interaction
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of cellulose in the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684]
subset: gosubset_prok
synonym: "catabolism by organism of cell wall cellulose in other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0030245 ! cellulose catabolic process
is_a: GO:0052354 ! catabolism by organism of carbohydrate in other organism involved in symbiotic interaction
is_a: GO:0052409 ! metabolism by organism of cell wall cellulose in other organism involved in symbiotic interaction
relationship: part_of GO:0044278 ! cell wall disruption in other organism
relationship: part_of GO:0052339 ! disruption by organism of cell wall of other organism involved in symbiotic interaction

[Term]
id: GO:0052341
name: catabolism by organism of cell wall pectin in other organism involved in symbiotic interaction
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of pectin in the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684]
subset: gosubset_prok
synonym: "catabolism by organism of cell wall pectin in other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0052354 ! catabolism by organism of carbohydrate in other organism involved in symbiotic interaction
is_a: GO:0052413 ! metabolism by organism of cell wall pectin in other organism involved in symbiotic interaction
relationship: part_of GO:0044278 ! cell wall disruption in other organism
relationship: part_of GO:0052339 ! disruption by organism of cell wall of other organism involved in symbiotic interaction

[Term]
id: GO:0052342
name: catabolism by organism of cell wall chitin in other organism involved in symbiotic interaction
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of chitin in the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684]
subset: gosubset_prok
synonym: "catabolism by organism of cell wall chitin in other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0006039 ! cell wall chitin catabolic process
is_a: GO:0052354 ! catabolism by organism of carbohydrate in other organism involved in symbiotic interaction
is_a: GO:0052411 ! metabolism by organism of cell wall chitin in other organism involved in symbiotic interaction
relationship: part_of GO:0052339 ! disruption by organism of cell wall of other organism involved in symbiotic interaction

[Term]
id: GO:0052343
name: obsolete positive regulation by organism of symbiont phytoalexin production
namespace: biological_process
def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of the production of phytoalexins as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "positive regulation by organism of symbiont phytoalexin production" EXACT []
is_obsolete: true

[Term]
id: GO:0052344
name: positive regulation by symbiont of host phytoalexin production
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the production of phytoalexins as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by symbiont of host phytoalexin production" NARROW []
synonym: "stimulation by symbiont of host phytoalexin production" NARROW []
synonym: "up regulation by symbiont of host phytoalexin production" EXACT []
synonym: "up-regulation by symbiont of host phytoalexin production" EXACT []
synonym: "upregulation by symbiont of host phytoalexin production" EXACT []
is_a: GO:0052165 ! modulation by symbiont of host phytoalexin production
is_a: GO:0052329 ! positive regulation by organism of phytoalexin production in other organism involved in symbiotic interaction
is_a: GO:0052556 ! positive regulation by symbiont of host immune response

[Term]
id: GO:0052345
name: positive regulation by organism of defense-related nitric oxide production in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the production of nitric oxide that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of defense-related nitric oxide production in other organism during symbiotic interaction" NARROW []
synonym: "positive regulation by organism of defense-related nitric oxide production in other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "positive regulation by organism of defense-related NO production in other organism during symbiotic interaction" RELATED []
synonym: "stimulation by organism of defense-related nitric oxide production in other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of defense-related nitric oxide production in other organism during symbiotic interaction" RELATED []
synonym: "up-regulation by organism of defense-related nitric oxide production in other organism during symbiotic interaction" RELATED []
synonym: "upregulation by organism of defense-related nitric oxide production in other organism during symbiotic interaction" RELATED []
is_a: GO:0052302 ! modulation by organism of defense-related nitric oxide production in other organism involved in symbiotic interaction
is_a: GO:0052555 ! positive regulation by organism of immune response of other organism involved in symbiotic interaction

[Term]
id: GO:0052346
name: obsolete positive regulation by organism of defense-related symbiont nitric oxide production
namespace: biological_process
def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of the production of nitric oxide as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "positive regulation by organism of defense-related symbiont nitric oxide production" EXACT []
synonym: "positive regulation by organism of defense-related symbiont NO production" EXACT []
is_obsolete: true

[Term]
id: GO:0052347
name: positive regulation by symbiont of defense-related host nitric oxide production
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the production of nitric oxide as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by symbiont of defense-related host nitric oxide production" NARROW []
synonym: "positive regulation by organism of defense-related host NO production" EXACT []
synonym: "stimulation by symbiont of defense-related host nitric oxide production" NARROW []
synonym: "up regulation by symbiont of defense-related host nitric oxide production" EXACT []
synonym: "up-regulation by symbiont of defense-related host nitric oxide production" EXACT []
synonym: "upregulation by symbiont of defense-related host nitric oxide production" EXACT []
is_a: GO:0052163 ! modulation by symbiont of defense-related host nitric oxide production
is_a: GO:0052345 ! positive regulation by organism of defense-related nitric oxide production in other organism involved in symbiotic interaction
is_a: GO:0052556 ! positive regulation by symbiont of host immune response

[Term]
id: GO:0052348
name: positive regulation by organism of defense-related reactive oxygen species production in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the production of reactive oxygen species that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of defense-related reactive oxygen species production in other organism during symbiotic interaction" NARROW []
synonym: "positive regulation by organism of defense-related active oxygen species production in other organism" EXACT []
synonym: "positive regulation by organism of defense-related AOS production in other organism" EXACT []
synonym: "positive regulation by organism of defense-related metabolic burst in other organism" EXACT []
synonym: "positive regulation by organism of defense-related oxidative burst in other organism" EXACT []
synonym: "positive regulation by organism of defense-related reactive oxidative species production in other organism" EXACT []
synonym: "positive regulation by organism of defense-related reactive oxygen intermediate production in other organism" EXACT []
synonym: "positive regulation by organism of defense-related reactive oxygen species production in other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "positive regulation by organism of defense-related respiratory burst in other organism" EXACT []
synonym: "positive regulation by organism of defense-related ROI production in other organism" EXACT []
synonym: "positive regulation by organism of defense-related ROS production in other organism" EXACT []
synonym: "stimulation by organism of defense-related reactive oxygen species production in other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of defense-related reactive oxygen species production in other organism during symbiotic interaction" RELATED []
synonym: "up-regulation by organism of defense-related reactive oxygen species production in other organism during symbiotic interaction" RELATED []
synonym: "upregulation by organism of defense-related reactive oxygen species production in other organism during symbiotic interaction" RELATED []
is_a: GO:0052303 ! modulation by organism of defense-related reactive oxygen species production in other organism involved in symbiotic interaction
is_a: GO:0052510 ! positive regulation by organism of defense response of other organism involved in symbiotic interaction
is_a: GO:0052555 ! positive regulation by organism of immune response of other organism involved in symbiotic interaction

[Term]
id: GO:0052349
name: obsolete positive regulation by organism of defense-related symbiont reactive oxygen species production
namespace: biological_process
def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of the production of reactive oxygen species as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "positive regulation by organism of defense-related symbiont active oxygen species production" EXACT []
synonym: "positive regulation by organism of defense-related symbiont AOS production" EXACT []
synonym: "positive regulation by organism of defense-related symbiont metabolic burst" EXACT []
synonym: "positive regulation by organism of defense-related symbiont oxidative burst" EXACT []
synonym: "positive regulation by organism of defense-related symbiont reactive oxidative species production" EXACT []
synonym: "positive regulation by organism of defense-related symbiont reactive oxygen intermediate production" EXACT []
synonym: "positive regulation by organism of defense-related symbiont reactive oxygen species production" EXACT []
synonym: "positive regulation by organism of defense-related symbiont respiratory burst" EXACT []
synonym: "positive regulation by organism of defense-related symbiont ROI production" EXACT []
synonym: "positive regulation by organism of defense-related symbiont ROS production" EXACT []
is_obsolete: true

[Term]
id: GO:0052350
name: obsolete induction by organism of induced systemic resistance in symbiont
namespace: biological_process
def: "OBSOLETE. Any process in which an organism activates induced systemic resistance in the symbiont; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "activation by organism of induced systemic resistance in symbiont" EXACT []
synonym: "activation by organism of ISR in symbiont" EXACT []
synonym: "induction by organism of induced systemic resistance in symbiont" EXACT []
synonym: "induction by organism of ISR in symbiont" EXACT []
is_obsolete: true

[Term]
id: GO:0052351
name: obsolete induction by organism of systemic acquired resistance in symbiont
namespace: biological_process
def: "OBSOLETE. Any process in which an organism activates systemic acquired resistance in the symbiont organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "activation by organism of SAR in symbiont" EXACT []
synonym: "activation by organism of systemic acquired resistance in symbiont" EXACT []
synonym: "induction by organism of SAR in symbiont" EXACT []
synonym: "induction by organism of systemic acquired resistance in symbiont" EXACT []
is_obsolete: true

[Term]
id: GO:0052352
name: biosynthesis by host of substance in symbiont
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism in its symbiont resulting in the formation of substances. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
is_a: GO:0052226 ! biosynthesis of substance in other organism involved in symbiotic interaction
is_a: GO:0052419 ! metabolism by host of substance in symbiont

[Term]
id: GO:0052353
name: catabolism by host of symbiont carbohydrate
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of carbohydrate molecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
is_a: GO:0052354 ! catabolism by organism of carbohydrate in other organism involved in symbiotic interaction
is_a: GO:0052360 ! catabolism by host of symbiont macromolecule
is_a: GO:0052406 ! metabolism by host of symbiont carbohydrate

[Term]
id: GO:0052354
name: catabolism by organism of carbohydrate in other organism involved in symbiotic interaction
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of carbohydrate molecules within a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684]
synonym: "catabolism by organism of carbohydrate in other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0044041 ! multi-organism carbohydrate catabolic process
is_a: GO:0052361 ! catabolism by organism of macromolecule in other organism involved in symbiotic interaction
is_a: GO:0052407 ! metabolism by organism of carbohydrate in other organism involved in symbiotic interaction

[Term]
id: GO:0052355
name: catabolism by host of symbiont cell wall cellulose
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of cellulose in the symbiont cell wall. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
is_a: GO:0052340 ! catabolism by organism of cell wall cellulose in other organism involved in symbiotic interaction
is_a: GO:0052353 ! catabolism by host of symbiont carbohydrate
is_a: GO:0052408 ! metabolism by host of symbiont cell wall cellulose
relationship: part_of GO:0052338 ! disruption by host of symbiont cell wall

[Term]
id: GO:0052356
name: catabolism by host of symbiont cell wall chitin
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of chitin in the symbiont cell wall. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
is_a: GO:0052342 ! catabolism by organism of cell wall chitin in other organism involved in symbiotic interaction
is_a: GO:0052353 ! catabolism by host of symbiont carbohydrate
is_a: GO:0052410 ! metabolism by host of symbiont cell wall chitin
relationship: part_of GO:0052338 ! disruption by host of symbiont cell wall

[Term]
id: GO:0052357
name: catabolism by host of symbiont cell wall pectin
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of pectin in the symbiont cell wall. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
is_a: GO:0052341 ! catabolism by organism of cell wall pectin in other organism involved in symbiotic interaction
is_a: GO:0052353 ! catabolism by host of symbiont carbohydrate
is_a: GO:0052412 ! metabolism by host of symbiont cell wall pectin
relationship: part_of GO:0052338 ! disruption by host of symbiont cell wall

[Term]
id: GO:0052358
name: catabolism by host of symbiont glucan
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of glucan molecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
is_a: GO:0052353 ! catabolism by host of symbiont carbohydrate
is_a: GO:0052359 ! catabolism by organism of glucan in other organism involved in symbiotic interaction
is_a: GO:0052414 ! metabolism by host of symbiont glucan

[Term]
id: GO:0052359
name: catabolism by organism of glucan in other organism involved in symbiotic interaction
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of glucan molecules within a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684]
synonym: "catabolism by organism of glucan in other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0000272 ! polysaccharide catabolic process
is_a: GO:0052354 ! catabolism by organism of carbohydrate in other organism involved in symbiotic interaction
is_a: GO:0052415 ! metabolism by organism of glucan in other organism involved in symbiotic interaction

[Term]
id: GO:0052360
name: catabolism by host of symbiont macromolecule
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of macromolecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
is_a: GO:0052361 ! catabolism by organism of macromolecule in other organism involved in symbiotic interaction
is_a: GO:0052364 ! catabolism by host of substance in symbiont
is_a: GO:0052416 ! metabolism by host of symbiont macromolecule

[Term]
id: GO:0052361
name: catabolism by organism of macromolecule in other organism involved in symbiotic interaction
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of macromolecules within a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684]
synonym: "catabolism by organism of macromolecule in other organism during symbiotic interaction" RELATED [goc:dph]
is_a: GO:0009057 ! macromolecule catabolic process
is_a: GO:0052227 ! catabolism of substance in other organism involved in symbiotic interaction
is_a: GO:0052229 ! metabolism of macromolecule in other organism involved in symbiotic interaction

[Term]
id: GO:0052362
name: catabolism by host of symbiont protein
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of protein macromolecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
is_a: GO:0052360 ! catabolism by host of symbiont macromolecule
is_a: GO:0052363 ! catabolism by organism of protein in other organism involved in symbiotic interaction
is_a: GO:0052417 ! metabolism by host of symbiont protein

[Term]
id: GO:0052363
name: catabolism by organism of protein in other organism involved in symbiotic interaction
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of protein macromolecules within the second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684]
synonym: "catabolism by organism of protein in other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0030163 ! protein catabolic process
is_a: GO:0052361 ! catabolism by organism of macromolecule in other organism involved in symbiotic interaction
is_a: GO:0052418 ! metabolism by organism of protein in other organism involved in symbiotic interaction

[Term]
id: GO:0052364
name: catabolism by host of substance in symbiont
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism in its symbiont resulting in the breakdown of substances. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
is_a: GO:0052227 ! catabolism of substance in other organism involved in symbiotic interaction
is_a: GO:0052419 ! metabolism by host of substance in symbiont

[Term]
id: GO:0052365
name: catabolism by host of symbiont xylan
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of xylan within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
is_a: GO:0052353 ! catabolism by host of symbiont carbohydrate
is_a: GO:0052366 ! catabolism by organism of xylan in other organism involved in symbiotic interaction
is_a: GO:0052420 ! metabolism by host of symbiont xylan

[Term]
id: GO:0052366
name: catabolism by organism of xylan in other organism involved in symbiotic interaction
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of xylan within a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684]
synonym: "catabolism by organism of xylan in other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0045493 ! xylan catabolic process
is_a: GO:0052354 ! catabolism by organism of carbohydrate in other organism involved in symbiotic interaction
is_a: GO:0052421 ! metabolism by organism of xylan in other organism involved in symbiotic interaction

[Term]
id: GO:0052367
name: disruption by host of symbiont cellular component
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of cellular components of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
synonym: "catabolism of symbiont cellular component by organism" EXACT []
synonym: "catabolism of symbiont structural constituent by organism" EXACT []
synonym: "degradation of symbiont cellular component by organism" EXACT []
synonym: "disassembly by host of symbiont cellular component" RELATED []
is_a: GO:0052187 ! modification by host of symbiont cellular component
is_a: GO:0052368 ! disruption by organism of cellular component in other organism involved in symbiotic interaction

[Term]
id: GO:0052368
name: disruption by organism of cellular component in other organism involved in symbiotic interaction
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of cellular components of a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684]
subset: gosubset_prok
synonym: "catabolism of cellular component in other organism" EXACT []
synonym: "catabolism of structural constituent in other organism" EXACT []
synonym: "degradation of cellular component in other organism" EXACT []
synonym: "disassembly by organism of cellular component in other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "disassembly by organism of cellular component in other organism involved in symbiotic interaction" RELATED []
is_a: GO:0052185 ! modification of structure of other organism involved in symbiotic interaction

[Term]
id: GO:0052369
name: positive regulation by symbiont of defense-related host reactive oxygen species production
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the production of reactive oxygen species as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by symbiont of defense-related host reactive oxygen species production" NARROW []
synonym: "positive regulation by organism of defense-related host active oxygen species production" EXACT []
synonym: "positive regulation by organism of defense-related host AOS production" EXACT []
synonym: "positive regulation by organism of defense-related host metabolic burst" EXACT []
synonym: "positive regulation by organism of defense-related host oxidative burst" EXACT []
synonym: "positive regulation by organism of defense-related host reactive oxidative species production" EXACT []
synonym: "positive regulation by organism of defense-related host reactive oxygen intermediate production" EXACT []
synonym: "positive regulation by organism of defense-related host respiratory burst" EXACT []
synonym: "positive regulation by organism of defense-related host ROI production" EXACT []
synonym: "positive regulation by organism of defense-related host ROS production" EXACT []
synonym: "stimulation by symbiont of defense-related host reactive oxygen species production" NARROW []
synonym: "up regulation by symbiont of defense-related host reactive oxygen species production" EXACT []
synonym: "up-regulation by symbiont of defense-related host reactive oxygen species production" EXACT []
synonym: "upregulation by symbiont of defense-related host reactive oxygen species production" EXACT []
is_a: GO:0052164 ! modulation by symbiont of defense-related host reactive oxygen species production
is_a: GO:0052348 ! positive regulation by organism of defense-related reactive oxygen species production in other organism involved in symbiotic interaction
is_a: GO:0052509 ! positive regulation by symbiont of host defense response
is_a: GO:0052556 ! positive regulation by symbiont of host immune response

[Term]
id: GO:0052370
name: entry of organism into cell of other organism by promotion of phagocytosis in other organism involved in symbiotic interaction
namespace: biological_process
def: "The invasion by an organism of a cell of a second organism by utilizing the second organism's phagocytosis mechanism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "entry of organism into cell of other organism by promotion of phagocytosis in other organism during symbiotic interaction" RELATED [GOC:tb]
is_a: GO:0051806 ! entry into cell of other organism involved in symbiotic interaction
is_a: GO:0052522 ! positive regulation by organism of phagocytosis in other organism involved in symbiotic interaction

[Term]
id: GO:0052371
name: regulation by organism of entry into other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent to which it enters into a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "modulation by organism of entry into other organism during symbiotic interaction" RELATED []
synonym: "regulation by organism of entry into other organism during symbiotic interaction" RELATED [GOC:tb]
is_a: GO:0040012 ! regulation of locomotion
is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism
relationship: regulates GO:0051828 ! entry into other organism involved in symbiotic interaction

[Term]
id: GO:0052372
name: modulation by symbiont of entry into host
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent to which it enters into the host organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0052371 ! regulation by organism of entry into other organism involved in symbiotic interaction

[Term]
id: GO:0052373
name: negative regulation by organism of entry into other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent to which it enters into a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "down regulation by organism of entry into other organism during symbiotic interaction" RELATED []
synonym: "down-regulation by organism of entry into other organism during symbiotic interaction" RELATED []
synonym: "downregulation by organism of entry into other organism during symbiotic interaction" RELATED []
synonym: "inhibition by organism of entry into other organism during symbiotic interaction" NARROW []
synonym: "negative regulation by organism of entry into other organism during symbiotic interaction" RELATED [GOC:tb]
is_a: GO:0043901 ! negative regulation of multi-organism process
is_a: GO:0052371 ! regulation by organism of entry into other organism involved in symbiotic interaction

[Term]
id: GO:0052374
name: negative regulation by symbiont of entry into host
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent to which it enters into the host organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "down regulation by symbiont of entry into host" EXACT []
synonym: "down-regulation by symbiont of entry into host" EXACT []
synonym: "downregulation by symbiont of entry into host" EXACT []
synonym: "inhibition by symbiont of entry into host" NARROW []
is_a: GO:0052372 ! modulation by symbiont of entry into host
is_a: GO:0052373 ! negative regulation by organism of entry into other organism involved in symbiotic interaction

[Term]
id: GO:0052375
name: obsolete evasion or tolerance by organism of symbiont-produced nitric oxide
namespace: biological_process
def: "OBSOLETE. The process by which an organism avoids the effects of nitric oxide produced as a defense response by the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "evasion or tolerance by organism of symbiont nitric oxide" EXACT []
synonym: "evasion or tolerance by organism of symbiont NO" EXACT []
synonym: "evasion or tolerance by organism of symbiont-produced nitric oxide" EXACT []
synonym: "evasion or tolerance by organism of symbiont-produced NO" EXACT []
synonym: "evasion or tolerance of nitric oxide produced by symbiont in response to organism" EXACT []
synonym: "evasion or tolerance of NO produced by symbiont in response to organism" EXACT []
is_obsolete: true

[Term]
id: GO:0052376
name: evasion or tolerance by organism of nitric oxide produced by other organism involved in symbiotic interaction
namespace: biological_process
def: "The process in which an organism avoids the effects of nitric oxide produced as a defense response by a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "evasion or tolerance by organism of nitric oxide produced by other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "evasion or tolerance by organism of NO produced by other organism during symbiotic interaction" RELATED []
synonym: "evasion or tolerance by organism of other organism-produced nitric oxide" RELATED []
synonym: "evasion or tolerance by organism of other organism-produced NO" RELATED []
is_a: GO:0051805 ! evasion or tolerance of immune response of other organism involved in symbiotic interaction
is_a: GO:0052551 ! response to defense-related nitric oxide production by other organism involved in symbiotic interaction

[Term]
id: GO:0052377
name: obsolete evasion or tolerance by organism of symbiont-produced phytoalexins
namespace: biological_process
def: "OBSOLETE. The process by which an organism avoids the effects of phytoalexins produced as a defense response by the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "evasion or tolerance by organism of symbiont phytoalexins" EXACT []
synonym: "evasion or tolerance by organism of symbiont-produced phytoalexins" EXACT []
synonym: "evasion or tolerance of phytoalexins produced by symbiont in response to organism" EXACT []
synonym: "symbiont phytoalexin detoxification" NARROW []
is_obsolete: true

[Term]
id: GO:0052378
name: evasion or tolerance by organism of phytoalexins produced by other organism involved in symbiotic interaction
namespace: biological_process
def: "The process in which an organism avoids the effects of phytoalexins produced as a defense response by the second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "evasion or tolerance by organism of phytoalexins produced by other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "evasion or tolerance of other organism phytoalexins" EXACT []
synonym: "evasion or tolerance of phytoalexins produced by other organism" EXACT []
synonym: "phytoalexin detoxification" NARROW []
is_a: GO:0051805 ! evasion or tolerance of immune response of other organism involved in symbiotic interaction
is_a: GO:0052549 ! response to phytoalexin production by other organism involved in symbiotic interaction

[Term]
id: GO:0052379
name: modulation by organism of entry into other organism via phagocytosis involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent to which it enters into a second organism via the phagocytotic processes of the other organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "modulation by organism of entry into other organism via other organism phagocytosis during symbiotic interaction" RELATED []
synonym: "modulation by organism of entry into other organism via phagocytosis during symbiotic interaction" RELATED [GOC:tb]
is_a: GO:0052371 ! regulation by organism of entry into other organism involved in symbiotic interaction

[Term]
id: GO:0052380
name: modulation by symbiont of entry into host via phagocytosis
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent to which it enters into the host, via the phagocytotic processes of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "modulation by organism of entry into host via host phagocytosis" EXACT []
is_a: GO:0052372 ! modulation by symbiont of entry into host
is_a: GO:0052379 ! modulation by organism of entry into other organism via phagocytosis involved in symbiotic interaction

[Term]
id: GO:0052381
name: tRNA dimethylallyltransferase activity
namespace: molecular_function
alt_id: GO:0004811
def: "Catalysis of the reaction: dimethylallyl diphosphate + tRNA = diphosphate + tRNA containing 6-dimethylallyladenosine." [EC:2.5.1.75]
comment: Note that this activity was formerly know in GO and EC as 'tRNA isopentenyltransferase' (EC 2.5.1.8, GO:0004811), but it is now known that dimethylallyl diphosphate, rather than isopentenyl diphosphate, is the substrate.
synonym: "dimethylallyl-diphosphate:tRNA dimethylallyltransferase activity" EXACT systematic_synonym [EC:2.5.1.75]
synonym: "tRNA isopentenyltransferase activity" RELATED [GOC:mah, GOC:vw]
synonym: "tRNA prenyltransferase activity" BROAD [EC:2.5.1.75]
xref: EC:2.5.1.75
xref: MetaCyc:RXN0-6274
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups
creation_date: 2010-07-23T03:07:33Z

[Term]
id: GO:0052382
name: induction by organism of innate immune response in other organism involved in symbiotic interaction
namespace: biological_process
def: "The activation by an organism of the innate immune response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of innate immune response in other organism involved in symbiotic interaction" EXACT []
synonym: "activation by organism of innate immunity in other organism involved in symbiotic interaction" EXACT []
synonym: "induction by organism of innate immunity in other organism during symbiotic interaction" RELATED [GOC:dph, GOC:pg]
is_a: GO:0052251 ! induction by organism of defense response of other organism involved in symbiotic interaction
is_a: GO:0052305 ! positive regulation by organism of innate immune response in other organism involved in symbiotic interaction
is_a: GO:0052558 ! induction by organism of immune response of other organism involved in symbiotic interaction

[Term]
id: GO:0052383
name: obsolete induction by organism of symbiont innate immunity
namespace: biological_process
def: "OBSOLETE. The activation by an organism of the innate immune response of the symbiont organism; the innate immune response is the symbiont's first line of defense against infection. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "activation by organism of symbiont innate immune response" EXACT []
synonym: "activation by organism of symbiont innate immunity" EXACT []
synonym: "induction by organism of symbiont innate immune response" EXACT []
synonym: "induction by organism of symbiont innate immunity" EXACT []
is_obsolete: true

[Term]
id: GO:0052384
name: obsolete evasion or tolerance by organism of symbiont-produced reactive oxygen species
namespace: biological_process
def: "OBSOLETE. The process by which an organism avoids the effects of reactive oxygen species produced as a defense response by the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "evasion by organism of cellular damage caused by symbiont oxidative burst" NARROW []
synonym: "evasion or tolerance by organism of reactive oxygen species produced during symbiont defense response" EXACT []
synonym: "evasion or tolerance by organism of symbiont-produced reactive oxygen species" EXACT []
synonym: "evasion or tolerance of defense-related symbiont metabolic burst" EXACT []
synonym: "evasion or tolerance of defense-related symbiont oxidative burst" EXACT []
synonym: "evasion or tolerance of defense-related symbiont respiratory burst" EXACT []
synonym: "evasion or tolerance of reactive oxygen species produced by symbiont in response to organism" EXACT []
synonym: "evasion or tolerance of symbiont-produced active oxygen species" EXACT []
synonym: "evasion or tolerance of symbiont-produced AOS" EXACT []
synonym: "evasion or tolerance of symbiont-produced reactive oxygen intermediates" EXACT []
synonym: "evasion or tolerance of symbiont-produced ROIs" EXACT []
synonym: "evasion or tolerance of symbiont-produced ROS" EXACT []
is_obsolete: true

[Term]
id: GO:0052385
name: evasion or tolerance by organism of reactive oxygen species produced by other organism involved in symbiotic interaction
namespace: biological_process
def: "The process in which an organism avoids the effects of reactive oxygen species produced as a defense response by a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "evasion by organism of cellular damage caused by oxidative burst of other organism" NARROW []
synonym: "evasion or tolerance by organism of defense-related metabolic burst in other organism during symbiotic interaction" RELATED []
synonym: "evasion or tolerance by organism of defense-related oxidative burst in other organism during symbiotic interaction" RELATED []
synonym: "evasion or tolerance by organism of defense-related respiratory burst in other organism during symbiotic interaction" EXACT []
synonym: "evasion or tolerance by organism of reactive oxygen species produced by other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "evasion or tolerance by organism of reactive oxygen species produced during defense response of other organism" RELATED []
synonym: "evasion or tolerance of active oxygen species produced by other organism" EXACT []
synonym: "evasion or tolerance of AOS produced by other organism" EXACT []
synonym: "evasion or tolerance of reactive oxygen intermediates produced by other organism" EXACT []
synonym: "evasion or tolerance of reactive oxygen species produced by other organism" EXACT []
synonym: "evasion or tolerance of ROIs produced by other organism" EXACT []
synonym: "evasion or tolerance of ROS produced by other organism" EXACT []
is_a: GO:0051805 ! evasion or tolerance of immune response of other organism involved in symbiotic interaction
is_a: GO:0052550 ! response to defense-related reactive oxygen species production by other organism involved in symbiotic interaction

[Term]
id: GO:0052386
name: cell wall thickening
namespace: biological_process
def: "A type of cell wall modification in which the cell wall is reinforced and made thicker." [GOC:mtg_pamgo_17jul06]
is_a: GO:0042545 ! cell wall modification

[Term]
id: GO:0052387
name: obsolete induction by organism of symbiont apoptosis
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates programmed cell death in the symbiont, where programmed cell death proceeds by apoptosis. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "activation by organism of symbiont apoptosis" EXACT []
synonym: "activation by organism of symbiont apoptotic programmed cell death" EXACT []
synonym: "induction by organism of symbiont apoptosis" EXACT []
synonym: "induction by organism of symbiont apoptotic programmed cell death" EXACT []
is_obsolete: true

[Term]
id: GO:0052389
name: positive regulation by symbiont of defense-related host calcium ion flux
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of fluxes of calcium ions that occur as part of the defense response of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by symbiont of defense-related host calcium ion flux" NARROW []
synonym: "positive regulation by organism of defense-related host Ca2+ flux" EXACT []
synonym: "stimulation by symbiont of defense-related host calcium ion flux" NARROW []
synonym: "up regulation by symbiont of defense-related host calcium ion flux" EXACT []
synonym: "up-regulation by symbiont of defense-related host calcium ion flux" EXACT []
synonym: "upregulation by symbiont of defense-related host calcium ion flux" EXACT []
is_a: GO:0052065 ! positive regulation by organism of defense-related calcium ion flux in other organism involved in symbiotic interaction
is_a: GO:0052162 ! modulation by symbiont of defense-related host calcium ion flux
is_a: GO:0052509 ! positive regulation by symbiont of host defense response

[Term]
id: GO:0052390
name: induction by symbiont of host innate immune response
namespace: biological_process
def: "The activation by an organism of the innate immune response of the host organism; the innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of host innate immune response" EXACT []
synonym: "activation by organism of host innate immunity" EXACT []
synonym: "induction by organism of host innate immune response" RELATED []
synonym: "induction by symbiont of host innate immunity" EXACT [GOC:pg]
is_a: GO:0052166 ! positive regulation by symbiont of host innate immune response
is_a: GO:0052382 ! induction by organism of innate immune response in other organism involved in symbiotic interaction
is_a: GO:0052559 ! induction by symbiont of host immune response

[Term]
id: GO:0052391
name: induction by symbiont of defense-related host calcium ion flux
namespace: biological_process
def: "The activation by an organism of a flux of calcium ions that occurs as part of the defense response of a host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of host Ca2+ flux" EXACT []
synonym: "activation by organism of host calcium ion flux" EXACT []
synonym: "induction by organism of host Ca2+ flux" EXACT []
is_a: GO:0044416 ! induction by symbiont of host defense response
is_a: GO:0052265 ! induction by organism of defense-related calcium ion flux in other organism involved in symbiotic interaction
is_a: GO:0052389 ! positive regulation by symbiont of defense-related host calcium ion flux

[Term]
id: GO:0052392
name: obsolete induction by organism of defense-related symbiont calcium ion flux
namespace: biological_process
def: "OBSOLETE. The activation by an organism of a flux of calcium ions that occurs as part of the defense response of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "activation by organism of symbiont Ca2+ flux" EXACT []
synonym: "activation by organism of symbiont calcium ion flux" EXACT []
synonym: "induction by organism of defense-related symbiont calcium ion flux" EXACT []
synonym: "induction by organism of symbiont Ca2+ flux" EXACT []
is_obsolete: true

[Term]
id: GO:0052393
name: induction by host of symbiont defense response
namespace: biological_process
def: "The activation by an organism of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc]
synonym: "activation of symbiont defense response" EXACT []
is_a: GO:0052197 ! positive regulation by host of symbiont defense response
is_a: GO:0052251 ! induction by organism of defense response of other organism involved in symbiotic interaction

[Term]
id: GO:0052394
name: obsolete induction by organism of defense-related symbiont cell wall thickening
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of symbiont processes resulting in the thickening of its cell walls, occurring as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "activation by organism of symbiont defense-related cell wall thickening" EXACT []
synonym: "activation by organism of symbiont defensive cell wall thickening" EXACT []
synonym: "induction by organism of defense-related symbiont cell wall thickening" EXACT []
synonym: "induction by organism of symbiont defensive cell wall thickening" EXACT []
is_obsolete: true

[Term]
id: GO:0052395
name: obsolete induction by organism of defense-related symbiont nitric oxide production
namespace: biological_process
def: "OBSOLETE. The activation by an organism of the production of nitric oxide as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "activation by organism of defense-related symbiont nitric acid production" EXACT []
synonym: "activation by organism of defense-related symbiont NO production" EXACT []
synonym: "induction by organism of defense-related symbiont nitric oxide production" EXACT []
synonym: "induction by organism of defense-related symbiont NO production" EXACT []
is_obsolete: true

[Term]
id: GO:0052396
name: obsolete induction by organism of symbiont non-apoptotic programmed cell death
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates programmed cell death in the symbiont, where programmed cell death proceeds by a non-apoptotic pathway. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "activation by organism of symbiont non-apoptotic programmed cell death" EXACT []
synonym: "induction by organism of symbiont non-apoptotic programmed cell death" EXACT []
is_obsolete: true

[Term]
id: GO:0052398
name: obsolete induction by organism of symbiont phytoalexin production
namespace: biological_process
def: "OBSOLETE. The activation by an organism of the production of phytoalexins as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "activation by organism of symbiont phytoalexin production" EXACT []
synonym: "induction by organism of symbiont phytoalexin production" EXACT []
is_obsolete: true

[Term]
id: GO:0052399
name: obsolete induction by organism of symbiont programmed cell death
namespace: biological_process
def: "OBSOLETE. The activation by an organism of programmed cell death in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "activation by organism of symbiont programmed cell death" EXACT []
synonym: "induction by organism of symbiont programmed cell death" EXACT []
is_obsolete: true

[Term]
id: GO:0052401
name: obsolete induction by organism of defense-related symbiont reactive oxygen species production
namespace: biological_process
def: "OBSOLETE. The activation by an organism of the production of reactive oxygen species as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "activation by organism of defense-related symbiont active oxygen species production" EXACT []
synonym: "activation by organism of defense-related symbiont AOS production" EXACT []
synonym: "activation by organism of defense-related symbiont metabolic burst" EXACT []
synonym: "activation by organism of defense-related symbiont oxidative burst" EXACT []
synonym: "activation by organism of defense-related symbiont reactive oxidative species production" EXACT []
synonym: "activation by organism of defense-related symbiont reactive oxygen intermediate production" EXACT []
synonym: "activation by organism of defense-related symbiont reactive oxygen species production" EXACT []
synonym: "activation by organism of defense-related symbiont respiratory burst" EXACT []
synonym: "activation by organism of defense-related symbiont ROI production" EXACT []
synonym: "activation by organism of defense-related symbiont ROS production" EXACT []
synonym: "induction by organism of defense-related symbiont active oxygen species production" EXACT []
synonym: "induction by organism of defense-related symbiont AOS production" EXACT []
synonym: "induction by organism of defense-related symbiont metabolic burst" EXACT []
synonym: "induction by organism of defense-related symbiont oxidative burst" EXACT []
synonym: "induction by organism of defense-related symbiont reactive oxygen intermediate production" EXACT []
synonym: "induction by organism of defense-related symbiont reactive oxygen species production" EXACT []
synonym: "induction by organism of defense-related symbiont respiratory burst" EXACT []
synonym: "induction by organism of defense-related symbiont ROI production" EXACT []
synonym: "induction by organism of defense-related symbiont ROS production" EXACT []
is_obsolete: true

[Term]
id: GO:0052402
name: obsolete induction by organism of symbiont resistance gene-dependent defense response
namespace: biological_process
def: "OBSOLETE. The activation by an organism of the resistance gene-dependent defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "activation by organism of defense response in symbiont by specific elicitors" EXACT []
synonym: "activation by organism of pathogen-race/symbiont plant cultivar-specific resistance in symbiont" EXACT []
synonym: "activation by organism of symbiont gene-for-gene resistance" EXACT []
synonym: "activation by organism of symbiont resistance gene-dependent defense response" EXACT []
synonym: "induction by organism of defense response in symbiont by specific elicitors" EXACT []
synonym: "induction by organism of pathogen-race/symbiont plant cultivar-specific resistance in symbiont" EXACT []
synonym: "induction by organism of symbiont gene-for-gene resistance" EXACT []
synonym: "induction by organism of symbiont resistance gene-dependent defense response" EXACT []
is_obsolete: true

[Term]
id: GO:0052403
name: negative regulation by host of symbiont catalytic activity
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of symbiont enzyme activity. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "down regulation by host of symbiont enzyme activity" EXACT []
synonym: "down-regulation by host of symbiont enzyme activity" EXACT []
synonym: "downregulation by host of symbiont enzyme activity" EXACT []
synonym: "inhibition by host of symbiont enzyme activity" NARROW []
synonym: "inhibition of symbiont enzyme activity" EXACT []
synonym: "negative regulation by host of symbiont enzyme activity" EXACT []
is_a: GO:0052199 ! negative regulation of catalytic activity in other organism involved in symbiotic interaction
is_a: GO:0052405 ! negative regulation by host of symbiont molecular function
is_a: GO:0052422 ! modulation by host of symbiont catalytic activity

[Term]
id: GO:0052404
name: negative regulation by host of symbiont peptidase activity
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of symbiont protease activity, the catalysis of the hydrolysis of peptide bonds in a protein. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb]
synonym: "down regulation by host of symbiont protease activity" NARROW []
synonym: "down-regulation by host of symbiont protease activity" NARROW []
synonym: "downregulation by host of symbiont protease activity" NARROW []
synonym: "inhibition by host of symbiont protease activity" NARROW []
synonym: "inhibition of symbiont protease activity" NARROW []
synonym: "negative regulation by host of symbiont protease activity" NARROW [GOC:dph, GOC:tb]
is_a: GO:0052180 ! negative regulation of peptidase activity in other organism involved in symbiotic interaction
is_a: GO:0052403 ! negative regulation by host of symbiont catalytic activity
is_a: GO:0052427 ! modulation by host of symbiont peptidase activity
intersection_of: GO:0052405 ! negative regulation by host of symbiont molecular function
intersection_of: negatively_regulates GO:0008233 ! peptidase activity
relationship: negatively_regulates GO:0008233 ! peptidase activity

[Term]
id: GO:0052405
name: negative regulation by host of symbiont molecular function
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the functional activity of symbiont proteins. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb]
synonym: "down regulation by host of symbiont protein function" EXACT []
synonym: "down-regulation by host of symbiont protein function" EXACT []
synonym: "downregulation by host of symbiont protein function" EXACT []
synonym: "inhibition by host of symbiont protein function" NARROW []
synonym: "inhibition of symbiont protein function" EXACT []
synonym: "negative regulation by host of symbiont protein function" EXACT [GOC:dph, GOC:tb]
is_a: GO:0052204 ! negative regulation of molecular function in other organism involved in symbiotic interaction
is_a: GO:0052428 ! modification by host of symbiont molecular function

[Term]
id: GO:0052406
name: metabolism by host of symbiont carbohydrate
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism involving carbohydrates within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0052407 ! metabolism by organism of carbohydrate in other organism involved in symbiotic interaction
is_a: GO:0052416 ! metabolism by host of symbiont macromolecule

[Term]
id: GO:0052407
name: metabolism by organism of carbohydrate in other organism involved in symbiotic interaction
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism involving carbohydrates within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "metabolism by organism of carbohydrate in other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0044040 ! multi-organism carbohydrate metabolic process
is_a: GO:0052229 ! metabolism of macromolecule in other organism involved in symbiotic interaction

[Term]
id: GO:0052408
name: metabolism by host of symbiont cell wall cellulose
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism involving cellulose in the cell wall of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0052406 ! metabolism by host of symbiont carbohydrate
is_a: GO:0052409 ! metabolism by organism of cell wall cellulose in other organism involved in symbiotic interaction

[Term]
id: GO:0052409
name: metabolism by organism of cell wall cellulose in other organism involved in symbiotic interaction
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism involving cellulose in the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "metabolism by organism of cell wall cellulose in other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0044037 ! multi-organism cell wall macromolecule metabolic process
is_a: GO:0044043 ! multi-organism glucan metabolic process
is_a: GO:0052407 ! metabolism by organism of carbohydrate in other organism involved in symbiotic interaction
is_a: GO:0052541 ! plant-type cell wall cellulose metabolic process

[Term]
id: GO:0052410
name: metabolism by host of symbiont cell wall chitin
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism involving chitin in the cell wall of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0052406 ! metabolism by host of symbiont carbohydrate
is_a: GO:0052411 ! metabolism by organism of cell wall chitin in other organism involved in symbiotic interaction

[Term]
id: GO:0052411
name: metabolism by organism of cell wall chitin in other organism involved in symbiotic interaction
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism involving chitin in the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "metabolism by organism of cell wall chitin in other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0006037 ! cell wall chitin metabolic process
is_a: GO:0044037 ! multi-organism cell wall macromolecule metabolic process
is_a: GO:0052407 ! metabolism by organism of carbohydrate in other organism involved in symbiotic interaction

[Term]
id: GO:0052412
name: metabolism by host of symbiont cell wall pectin
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism involving pectin in the cell wall of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0052406 ! metabolism by host of symbiont carbohydrate
is_a: GO:0052413 ! metabolism by organism of cell wall pectin in other organism involved in symbiotic interaction

[Term]
id: GO:0052413
name: metabolism by organism of cell wall pectin in other organism involved in symbiotic interaction
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism involving pectin in the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "metabolism by organism of cell wall pectin in other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0044037 ! multi-organism cell wall macromolecule metabolic process
is_a: GO:0052407 ! metabolism by organism of carbohydrate in other organism involved in symbiotic interaction
is_a: GO:0052546 ! cell wall pectin metabolic process

[Term]
id: GO:0052414
name: metabolism by host of symbiont glucan
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism involving glucans within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0052406 ! metabolism by host of symbiont carbohydrate
is_a: GO:0052415 ! metabolism by organism of glucan in other organism involved in symbiotic interaction

[Term]
id: GO:0052415
name: metabolism by organism of glucan in other organism involved in symbiotic interaction
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism involving glucans within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "metabolism by organism of glucan in other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0044043 ! multi-organism glucan metabolic process
is_a: GO:0052407 ! metabolism by organism of carbohydrate in other organism involved in symbiotic interaction

[Term]
id: GO:0052416
name: metabolism by host of symbiont macromolecule
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism involving macromolecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0052229 ! metabolism of macromolecule in other organism involved in symbiotic interaction
is_a: GO:0052419 ! metabolism by host of substance in symbiont

[Term]
id: GO:0052417
name: metabolism by host of symbiont protein
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism involving protein macromolecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0052416 ! metabolism by host of symbiont macromolecule
is_a: GO:0052418 ! metabolism by organism of protein in other organism involved in symbiotic interaction

[Term]
id: GO:0052418
name: metabolism by organism of protein in other organism involved in symbiotic interaction
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism involving protein macromolecules within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "metabolism by organism of protein in other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0019538 ! protein metabolic process
is_a: GO:0052229 ! metabolism of macromolecule in other organism involved in symbiotic interaction

[Term]
id: GO:0052419
name: metabolism by host of substance in symbiont
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism in its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0051851 ! modification by host of symbiont morphology or physiology
is_a: GO:0052214 ! metabolism of substance in other organism involved in symbiotic interaction

[Term]
id: GO:0052420
name: metabolism by host of symbiont xylan
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism involving xylan within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0052406 ! metabolism by host of symbiont carbohydrate
is_a: GO:0052421 ! metabolism by organism of xylan in other organism involved in symbiotic interaction

[Term]
id: GO:0052421
name: metabolism by organism of xylan in other organism involved in symbiotic interaction
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism involving xylan within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "metabolism by organism of xylan in other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0044037 ! multi-organism cell wall macromolecule metabolic process
is_a: GO:0045491 ! xylan metabolic process
is_a: GO:0052407 ! metabolism by organism of carbohydrate in other organism involved in symbiotic interaction

[Term]
id: GO:0052422
name: modulation by host of symbiont catalytic activity
namespace: biological_process
def: "The process in which a host organism effects a change in the enzyme activity of its symbiont organism." [GOC:mtg_pamgo_17jul06, GOC:tb]
synonym: "modulation by host of symbiont enzyme activity" EXACT [GOC:tb]
is_a: GO:0052055 ! modulation by symbiont of host molecular function
is_a: GO:0052203 ! modulation of catalytic activity in other organism involved in symbiotic interaction
is_a: GO:0052428 ! modification by host of symbiont molecular function
intersection_of: GO:0052055 ! modulation by symbiont of host molecular function
intersection_of: regulates GO:0003824 ! catalytic activity
relationship: regulates GO:0003824 ! catalytic activity

[Term]
id: GO:0052423
name: positive regulation by organism of resistance gene-dependent defense response of other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the resistance gene-dependent defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of resistance gene-dependent defense response of other organism during symbiotic interaction" NARROW []
synonym: "positive regulation by organism of defense response in other organism by specific elicitors" EXACT []
synonym: "positive regulation by organism of gene-for-gene resistance in other organism" EXACT []
synonym: "positive regulation by organism of resistance gene-dependent defense response of other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "stimulation by organism of resistance gene-dependent defense response of other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of resistance gene-dependent defense response of other organism during symbiotic interaction" RELATED []
synonym: "up-regulation by organism of resistance gene-dependent defense response of other organism during symbiotic interaction" RELATED []
synonym: "upregulation by organism of resistance gene-dependent defense response of other organism during symbiotic interaction" RELATED []
is_a: GO:0052297 ! modulation by organism of resistance gene-dependent defense response of other organism involved in symbiotic interaction
is_a: GO:0052555 ! positive regulation by organism of immune response of other organism involved in symbiotic interaction

[Term]
id: GO:0052424
name: obsolete modification by organism of symbiont morphology or physiology via protein secreted by type III secretion system
namespace: biological_process
def: "OBSOLETE. The process by which an organism effects a change in the structure or function of its symbiont organism, mediated by a substance secreted by a type III secretion system in the organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modification by organism of symbiont morphology or physiology via protein secreted by type III secretion system" EXACT []
is_obsolete: true

[Term]
id: GO:0052425
name: obsolete modification by organism of symbiont morphology or physiology via protein secreted by type II secretion system
namespace: biological_process
def: "OBSOLETE. The process by which an organism effects a change in the structure or function of its symbiont organism, mediated by a substance secreted by a type II secretion system in the organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modification by organism of symbiont morphology or physiology via protein secreted by type II secretion system" EXACT []
is_obsolete: true

[Term]
id: GO:0052426
name: obsolete modification by organism of symbiont morphology or physiology via substance secreted by type IV secretion system
namespace: biological_process
def: "OBSOLETE. The process by which an organism effects a change in the structure or function of its symbiont organism, mediated by a substance secreted by a type IV secretion system in the organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modification by organism of symbiont morphology or physiology via substance secreted by type IV secretion system" EXACT []
is_obsolete: true

[Term]
id: GO:0052427
name: modulation by host of symbiont peptidase activity
namespace: biological_process
def: "The process in which an organism effects a change in symbiont peptidase activity, the catalysis of the hydrolysis of peptide bonds in a protein. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "modulation by host of symbiont protease activity" NARROW [GOC:bf]
is_a: GO:0052198 ! modulation of peptidase activity in other organism involved in symbiotic interaction
is_a: GO:0052422 ! modulation by host of symbiont catalytic activity

[Term]
id: GO:0052428
name: modification by host of symbiont molecular function
namespace: biological_process
def: "The process in which an organism effects a change in the function of proteins in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb]
synonym: "modification by host of symbiont protein function" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051851 ! modification by host of symbiont morphology or physiology
is_a: GO:0052205 ! modulation of molecular function in other organism involved in symbiotic interaction

[Term]
id: GO:0052429
name: obsolete modulation by organism of symbiont B-cell mediated immune response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the B-cell mediated immune response of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of symbiont B-cell mediated immune response" EXACT []
synonym: "regulation by organism of symbiont B-cell mediated immune response" EXACT []
is_obsolete: true

[Term]
id: GO:0052430
name: modulation by host of symbiont RNA levels
namespace: biological_process
def: "The alteration by an organism of the levels of RNA in a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0051851 ! modification by host of symbiont morphology or physiology
is_a: GO:0052249 ! modulation of RNA levels in other organism involved in symbiotic interaction

[Term]
id: GO:0052431
name: obsolete modulation by organism of symbiont T-cell mediated immune response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the T-cell mediated immune response of a symbiont organism, where the two organisms are in a symbiotic interaction. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of symbiont T-cell mediated immune response" EXACT []
is_obsolete: true

[Term]
id: GO:0052432
name: obsolete modulation by organism of symbiont apoptosis
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of programmed cell death in the symbiont, where programmed cell death proceeds by apoptosis. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of symbiont apoptosis" EXACT []
synonym: "modulation by organism of symbiont apoptotic programmed cell death" EXACT []
is_obsolete: true

[Term]
id: GO:0052433
name: modulation by organism of apoptotic process in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of programmed cell death by apoptosis in a second organism, where the two organisms are in a symbiotic interaction." [GOC:jl, GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of apoptosis in other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "modulation by organism of apoptosis in other organism involved in symbiotic interaction" NARROW []
synonym: "modulation by organism of apoptotic programmed cell death in other organism during symbiotic interaction" EXACT []
is_a: GO:0044532 ! modulation of apoptotic process in other organism
is_a: GO:0052248 ! modulation of programmed cell death in other organism involved in symbiotic interaction

[Term]
id: GO:0052434
name: obsolete modulation by organism of symbiont cell-mediated immune response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of any form of cell-based immune response of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of symbiont cell-based immune response" EXACT []
synonym: "modulation by organism of symbiont cell-mediated immune response" EXACT []
is_obsolete: true

[Term]
id: GO:0052435
name: modulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of symbiont MAP kinase-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "modulation of defense-related symbiont MAPK-mediated signal transduction pathway by organism" EXACT []
synonym: "modulation of defense-related symbiont mitogen activated protein kinase-mediated signal transduction pathway by organism" EXACT []
is_a: GO:0052277 ! modulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism involved in symbiotic interaction
is_a: GO:0075099 ! modulation by host of symbiont protein kinase-mediated signal transduction

[Term]
id: GO:0052436
name: obsolete modulation by organism of defense-related symbiont calcium-dependent protein kinase pathway
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the symbiont calcium-dependent protein kinase signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of defense-related symbiont calcium-dependent protein kinase pathway" EXACT []
synonym: "modulation by organism of defense-related symbiont CDPK pathway" EXACT []
is_obsolete: true

[Term]
id: GO:0052437
name: obsolete modulation by organism of defense-related symbiont calcium ion flux
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of calcium ion fluxes as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of defense-related symbiont Ca2+ flux" EXACT []
synonym: "modulation by organism of defense-related symbiont calcium ion flux" EXACT []
is_obsolete: true

[Term]
id: GO:0052438
name: obsolete modulation by organism of defense-related symbiont callose deposition
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of callose deposition by the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of defense-related symbiont callose deposition" EXACT []
is_obsolete: true

[Term]
id: GO:0052439
name: obsolete modulation by organism of defense-related symbiont cell wall callose deposition
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the deposition of callose by the symbiont in its cell walls, occurring as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of defense-related symbiont cell wall callose deposition" EXACT []
is_obsolete: true

[Term]
id: GO:0052440
name: obsolete modulation by organism of defense-related symbiont ethylene-mediated signal transduction pathway
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of symbiont ethylene-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of defense-related symbiont ethylene-mediated signal transduction pathway" EXACT []
is_obsolete: true

[Term]
id: GO:0052441
name: modulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of ethylene-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0052250 ! modulation of signal transduction in other organism involved in symbiotic interaction
is_a: GO:0052255 ! modulation by organism of defense response of other organism involved in symbiotic interaction

[Term]
id: GO:0052442
name: obsolete modulation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of symbiont jasmonic acid-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway" EXACT []
synonym: "modulation of defense-related symbiont JA-mediated signal transduction pathway by organism" EXACT []
is_obsolete: true

[Term]
id: GO:0052443
name: modulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of jasmonic acid-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "modulation of defense-related JA-mediated signal transduction pathway in other organism" EXACT []
is_a: GO:0052250 ! modulation of signal transduction in other organism involved in symbiotic interaction
is_a: GO:0052255 ! modulation by organism of defense response of other organism involved in symbiotic interaction

[Term]
id: GO:0052444
name: obsolete modulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of symbiont salicylic acid-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway" EXACT []
synonym: "modulation of defense-related symbiont SA-mediated signal transduction pathway by organism" EXACT []
is_obsolete: true

[Term]
id: GO:0052445
name: modulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of salicylic acid-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "modulation of defense-related SA-mediated signal transduction pathway in other organism" EXACT []
is_a: GO:0052250 ! modulation of signal transduction in other organism involved in symbiotic interaction
is_a: GO:0052255 ! modulation by organism of defense response of other organism involved in symbiotic interaction

[Term]
id: GO:0052446
name: obsolete modulation by organism of defense-related symbiont cell wall thickening
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of symbiont processes resulting in the thickening of its cell walls, occurring as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of defense-related symbiont cell wall thickening" EXACT []
synonym: "modulation by organism of symbiont defensive cell wall thickening" RELATED []
is_obsolete: true

[Term]
id: GO:0052447
name: obsolete modulation by organism of symbiont ethylene-mediated defense response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the ethylene-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of symbiont ethylene-mediated defense response" EXACT []
is_obsolete: true

[Term]
id: GO:0052448
name: obsolete modulation by organism of ethylene levels in symbiont
namespace: biological_process
def: "OBSOLETE. The alteration by an organism of the levels of ethylene in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of ethylene levels in symbiont" EXACT []
is_obsolete: true

[Term]
id: GO:0052449
name: modulation by organism of ethylene levels in other organism involved in symbiotic interaction
namespace: biological_process
def: "The alteration by an organism of the levels of ethylene in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of ethylene levels in other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0052186 ! modulation by organism of hormone or growth regulator levels in other organism involved in symbiotic interaction

[Term]
id: GO:0052450
name: obsolete modulation by organism of induced systemic resistance in symbiont
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of induced systemic resistance in the symbiont organism; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of induced systemic resistance in symbiont" EXACT []
is_obsolete: true

[Term]
id: GO:0052451
name: obsolete modulation by organism of symbiont inflammatory response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the inflammatory response of a symbiont organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of symbiont inflammatory response" EXACT []
is_obsolete: true

[Term]
id: GO:0052452
name: obsolete modulation by organism of symbiont innate immunity
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the innate immune response of the symbiont organism; the innate immune response is the symbiont's first line of defense against infection. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of symbiont innate immunity" EXACT []
synonym: "modulation of symbiont innate immune response" EXACT []
is_obsolete: true

[Term]
id: GO:0052453
name: obsolete modulation by organism of symbiont intracellular transport
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the directed movement of substances within the cell or cells of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of symbiont intracellular transport" EXACT []
synonym: "modulation of symbiont intracellular trafficking" EXACT []
is_obsolete: true

[Term]
id: GO:0052454
name: obsolete modulation by organism of symbiont jasmonic acid-mediated defense response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the jasmonic acid-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of symbiont JA-mediated defense response" EXACT []
synonym: "modulation by organism of symbiont jasmonic acid-mediated defense response" EXACT []
is_obsolete: true

[Term]
id: GO:0052455
name: obsolete modulation by organism of jasmonic acid levels in symbiont
namespace: biological_process
def: "OBSOLETE. The alteration by an organism of the levels of jasmonic acid in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of jasmonic acid levels in symbiont" EXACT []
is_obsolete: true

[Term]
id: GO:0052456
name: modulation by organism of jasmonic acid levels in other organism involved in symbiotic interaction
namespace: biological_process
def: "The alteration by an organism of the levels of jasmonic acid in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of jasmonic acid levels in other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0052186 ! modulation by organism of hormone or growth regulator levels in other organism involved in symbiotic interaction

[Term]
id: GO:0052457
name: obsolete modulation by organism of defense-related symbiont nitric oxide production
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the production of nitric oxide as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of defense-related symbiont nitric oxide production" EXACT []
synonym: "modulation by organism of defense-related symbiont NO production" EXACT []
is_obsolete: true

[Term]
id: GO:0052458
name: obsolete modulation by organism of symbiont non-apoptotic programmed cell death
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of programmed cell death in the symbiont, where programmed cell death proceeds by a non-apoptotic pathway. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of symbiont non-apoptotic programmed cell death" EXACT []
is_obsolete: true

[Term]
id: GO:0052460
name: modulation by host of nutrient release from symbiont
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of the release of nutrients from a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0051851 ! modification by host of symbiont morphology or physiology
is_a: GO:0052313 ! modulation of nutrient release from other organism involved in symbiotic interaction
relationship: part_of GO:0051850 ! acquisition of nutrients from symbiont

[Term]
id: GO:0052461
name: obsolete modulation by organism of pathogen-associated molecular pattern-induced symbiont innate immunity
namespace: biological_process
def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of pathogen-associated molecular pattern-induced symbiont innate immunity" EXACT []
is_obsolete: true

[Term]
id: GO:0052462
name: modulation by host of symbiont phagocytosis
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0051851 ! modification by host of symbiont morphology or physiology
is_a: GO:0052231 ! modulation of phagocytosis in other organism involved in symbiotic interaction

[Term]
id: GO:0052463
name: obsolete modulation by organism of symbiont phytoalexin production
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of production of phytoalexins as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of symbiont phytoalexin production" EXACT []
is_obsolete: true

[Term]
id: GO:0052464
name: obsolete modulation by organism of symbiont programmed cell death
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of programmed cell death in a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of symbiont programmed cell death" EXACT []
synonym: "modulation of symbiont HR" BROAD []
synonym: "modulation of symbiont hypersensitive response" NARROW []
synonym: "modulation of symbiont PCD" EXACT []
is_obsolete: true

[Term]
id: GO:0052465
name: obsolete modulation by organism of defense-related symbiont reactive oxygen species production
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the production of reactive oxygen species as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of defense-related symbiont active oxygen species production" EXACT []
synonym: "modulation by organism of defense-related symbiont AOS production" EXACT []
synonym: "modulation by organism of defense-related symbiont metabolic burst" EXACT []
synonym: "modulation by organism of defense-related symbiont oxidative burst" EXACT []
synonym: "modulation by organism of defense-related symbiont reactive oxidative species production" EXACT []
synonym: "modulation by organism of defense-related symbiont reactive oxygen intermediate production" EXACT []
synonym: "modulation by organism of defense-related symbiont reactive oxygen species production" EXACT []
synonym: "modulation by organism of defense-related symbiont respiratory burst" EXACT []
synonym: "modulation by organism of defense-related symbiont ROI production" EXACT []
synonym: "modulation by organism of defense-related symbiont ROS production" EXACT []
is_obsolete: true

[Term]
id: GO:0052466
name: obsolete modulation by organism of symbiont resistance gene-dependent defense response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the resistance gene-dependent defense response of the symbiont. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of defense response in symbiont by specific elicitors" EXACT []
synonym: "modulation by organism of pathogen-race/symbiont plant cultivar-specific resistance in symbiont" EXACT []
synonym: "modulation by organism of symbiont gene-for-gene resistance" EXACT []
synonym: "modulation by organism of symbiont resistance gene-dependent defense response" EXACT []
is_obsolete: true

[Term]
id: GO:0052467
name: obsolete modulation by organism of symbiont salicylic acid-mediated defense response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the salicylic acid-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of symbiont SA-mediated defense response" EXACT []
synonym: "modulation by organism of symbiont salicylic acid-mediated defense response" EXACT []
is_obsolete: true

[Term]
id: GO:0052468
name: obsolete modulation by organism of salicylic acid levels in symbiont
namespace: biological_process
def: "OBSOLETE. The alteration by an organism of the levels of salicylic acid in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of salicylic acid levels in symbiont" EXACT []
is_obsolete: true

[Term]
id: GO:0052469
name: modulation by organism of salicylic acid levels in other organism involved in symbiotic interaction
namespace: biological_process
def: "The alteration by an organism of the levels of salicylic acid in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of salicylic acid levels in other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0052186 ! modulation by organism of hormone or growth regulator levels in other organism involved in symbiotic interaction

[Term]
id: GO:0052470
name: modulation by host of symbiont signal transduction pathway
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of the symbiont signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0051851 ! modification by host of symbiont morphology or physiology
is_a: GO:0052250 ! modulation of signal transduction in other organism involved in symbiotic interaction

[Term]
id: GO:0052471
name: obsolete modulation by organism of systemic acquired resistance in symbiont
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of systemic acquired resistance in the symbiont organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of systemic acquired resistance in symbiont" EXACT []
is_obsolete: true

[Term]
id: GO:0052472
name: modulation by host of symbiont transcription
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of its symbiont's transcription." [GOC:mtg_pamgo_17jul06]
is_a: GO:0051851 ! modification by host of symbiont morphology or physiology
is_a: GO:0052312 ! modulation of transcription in other organism involved in symbiotic interaction

[Term]
id: GO:0052473
name: obsolete negative regulation by organism of symbiont B-cell mediated immune response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the B-cell mediated immune response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "negative regulation by organism of symbiont B-cell mediated immune response" EXACT []
is_obsolete: true

[Term]
id: GO:0052474
name: obsolete negative regulation by organism of symbiont T-cell mediated immune response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the T-cell mediated immune response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "negative regulation by organism of symbiont T-cell mediated immune response" EXACT []
is_obsolete: true

[Term]
id: GO:0052475
name: obsolete negative regulation by organism of symbiont cell-mediated immune response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the cell mediated immune response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "negative regulation by organism of symbiont cell-based immune response" EXACT []
synonym: "negative regulation by organism of symbiont cell-mediated immune response" EXACT []
is_obsolete: true

[Term]
id: GO:0052476
name: obsolete negative regulation by organism of defense-related symbiont MAP kinase-mediated signal transduction pathway
namespace: biological_process
def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of symbiont MAP kinase-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a valid biological process that occurs in nature.
synonym: "negative regulation by organism of defense-related symbiont MAP kinase-mediated signal transduction pathway" EXACT []
synonym: "negative regulation by organism of defense-related symbiont MAPK-mediated signal transduction pathway" EXACT []
synonym: "negative regulation by organism of defense-related symbiont mitogen-activated protein kinase-mediated signal transduction pathway" EXACT []
synonym: "suppression by organism of defense-related symbiont MAP kinase-mediated signal transduction pathway" EXACT []
is_obsolete: true

[Term]
id: GO:0052477
name: obsolete negative regulation by organism of defense-related symbiont callose deposition
namespace: biological_process
def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of callose deposition performed by the symbiont as part of its defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "negative regulation by organism of defense-related symbiont callose deposition" EXACT []
synonym: "suppression by organism of defense-related symbiont callose deposition" EXACT []
is_obsolete: true

[Term]
id: GO:0052478
name: obsolete negative regulation by organism of defense-related symbiont cell wall callose deposition
namespace: biological_process
def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the deposition of callose by the symbiont in its cell walls, occurring as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a valid biological process that occurs in nature.
synonym: "negative regulation by organism of defense-related symbiont cell wall callose deposition" EXACT []
is_obsolete: true

[Term]
id: GO:0052479
name: obsolete negative regulation by organism of defense-related symbiont ethylene-mediated signal transduction pathway
namespace: biological_process
def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of symbiont ethylene-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "negative regulation by organism of defense-related symbiont ethylene-mediated signal transduction pathway" EXACT []
synonym: "suppression by organism of defense-related symbiont ethylene-mediated signal transduction pathway" EXACT []
is_obsolete: true

[Term]
id: GO:0052480
name: obsolete negative regulation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway
namespace: biological_process
def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of symbiont jasmonic acid-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "negative regulation by organism of defense-related symbiont JA-mediated signal transduction pathway" EXACT []
synonym: "negative regulation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway" EXACT []
is_obsolete: true

[Term]
id: GO:0052481
name: obsolete negative regulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway
namespace: biological_process
def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of symbiont salicylic acid-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "negative modulation by organism of defense-related symbiont SA-mediated signal transduction pathway" EXACT []
synonym: "negative modulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway" EXACT []
synonym: "negative regulation by organism of defense-related symbiont SA-mediated signal transduction pathway" EXACT []
synonym: "negative regulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway" EXACT []
is_obsolete: true

[Term]
id: GO:0052482
name: defense response by cell wall thickening
namespace: biological_process
def: "A type of cell wall modification, in which the cell wall is reinforced and made thicker, that occurs as part of the defense response of an organism." [GOC:mtg_pamgo_17jul06]
synonym: "cell wall thickening during defense response" RELATED [GOC:dph]
is_a: GO:0006952 ! defense response
is_a: GO:0033554 ! cellular response to stress
is_a: GO:0052386 ! cell wall thickening

[Term]
id: GO:0052483
name: negative regulation by organism of entry into cell of other organism via phagocytosis involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism stops or prevents itself undergoing phagocytosis into a cell in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "down regulation by organism of entry into cell of other organism via phagocytosis during symbiotic interaction" RELATED []
synonym: "down-regulation by organism of entry into cell of other organism via phagocytosis during symbiotic interaction" RELATED []
synonym: "downregulation by organism of entry into cell of other organism via phagocytosis during symbiotic interaction" RELATED []
synonym: "inhibition by organism of entry into cell of other organism via phagocytosis during symbiotic interaction" NARROW []
synonym: "negative regulation by organism of entry into cell of other organism via other organism phagocytosis during symbiotic interaction" RELATED []
synonym: "negative regulation by organism of entry into cell of other organism via phagocytosis during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0051834 ! evasion or tolerance of defenses of other organism involved in symbiotic interaction
is_a: GO:0052373 ! negative regulation by organism of entry into other organism involved in symbiotic interaction
is_a: GO:0052379 ! modulation by organism of entry into other organism via phagocytosis involved in symbiotic interaction

[Term]
id: GO:0052484
name: obsolete negative regulation by organism of symbiont ethylene-mediated defense response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the ethylene-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "negative regulation by organism of symbiont ethylene-mediated defense response" EXACT []
synonym: "suppression by organism of symbiont ethylene-mediated defense response" EXACT []
is_obsolete: true

[Term]
id: GO:0052485
name: obsolete negative regulation by organism of symbiont inflammatory response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the inflammatory response of a symbiont organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "negative regulation by organism of symbiont inflammatory response" EXACT []
is_obsolete: true

[Term]
id: GO:0052486
name: obsolete negative regulation by organism of symbiont innate immunity
namespace: biological_process
def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the innate immune response of the symbiont organism, the symbiont's first line of defense against infection. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "negative regulation by organism of symbiont innate immunity" EXACT []
synonym: "negative regulation of symbiont innate immune response" EXACT []
is_obsolete: true

[Term]
id: GO:0052487
name: obsolete negative regulation by organism of symbiont jasmonic acid-mediated defense response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the jasmonic acid-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "negative regulation by organism of symbiont jasmonic acid-mediated defense response" EXACT []
synonym: "suppression by organism of symbiont JA-mediated defense response" EXACT []
is_obsolete: true

[Term]
id: GO:0052488
name: obsolete negative regulation by organism of pathogen-associated molecular pattern-induced symbiont innate immunity
namespace: biological_process
def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "negative regulation by organism of pathogen-associated molecular pattern-induced symbiont innate immunity" EXACT []
synonym: "suppression of general elicitor induced symbiont innate immunity" EXACT []
synonym: "suppression of general elicitor-induced symbiont innate immunity" EXACT []
synonym: "suppression of MAMP induced symbiont innate immunity" EXACT []
synonym: "suppression of MAMP-induced symbiont innate immunity" EXACT []
synonym: "suppression of PAMP induced symbiont innate immunity" EXACT []
synonym: "suppression of PAMP-induced symbiont innate immunity" EXACT []
synonym: "suppression of pathogen-associated molecular pattern-induced symbiont innate immunity" EXACT []
is_obsolete: true

[Term]
id: GO:0052489
name: negative regulation by host of symbiont programmed cell death
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of programmed cell death in a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by host of symbiont programmed cell death" EXACT []
synonym: "down-regulation by host of symbiont programmed cell death" EXACT []
synonym: "downregulation by host of symbiont programmed cell death" EXACT []
synonym: "inhibition by host of symbiont programmed cell death" NARROW []
synonym: "inhibition of symbiont programmed cell death" EXACT []
is_a: GO:0052490 ! negative regulation by organism of programmed cell death in other organism involved in symbiotic interaction

[Term]
id: GO:0052490
name: negative regulation by organism of programmed cell death in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of programmed cell death in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by organism of programmed cell death in other organism during symbiotic interaction" RELATED []
synonym: "down-regulation by organism of programmed cell death in other organism during symbiotic interaction" RELATED []
synonym: "downregulation by organism of programmed cell death in other organism during symbiotic interaction" RELATED []
synonym: "inhibition by organism of programmed cell death in other organism during symbiotic interaction" NARROW []
synonym: "inhibition of programmed cell death in other organism" EXACT []
synonym: "negative regulation by organism of programmed cell death in other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0043069 ! negative regulation of programmed cell death
is_a: GO:0052248 ! modulation of programmed cell death in other organism involved in symbiotic interaction

[Term]
id: GO:0052491
name: obsolete negative regulation by organism of symbiont salicylic acid-mediated defense response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the salicylic acid-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "negative regulation by organism of symbiont salicylic acid-mediated defense response" EXACT []
synonym: "negative regulation of symbiont SA-mediated defense response" EXACT []
synonym: "suppression by organism of symbiont salicylic acid-mediated defense response" EXACT []
synonym: "suppression of symbiont SA mediated defense response" EXACT []
is_obsolete: true

[Term]
id: GO:0052492
name: negative regulation by host of symbiont signal transduction pathway
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the symbiont signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "down regulation by host of symbiont signal transduction pathway" EXACT []
synonym: "down-regulation by host of symbiont signal transduction pathway" EXACT []
synonym: "downregulation by host of symbiont signal transduction pathway" EXACT []
synonym: "inhibition by host of symbiont signal transduction pathway" NARROW []
synonym: "negative modulation by organism of symbiont signal transduction pathway" EXACT []
is_a: GO:0052470 ! modulation by host of symbiont signal transduction pathway
is_a: GO:0052493 ! negative regulation by organism of signal transduction in other organism involved in symbiotic interaction

[Term]
id: GO:0052493
name: negative regulation by organism of signal transduction in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the second organism signal transduction pathways, the cascade of processes by which a signal interacts with a receptor, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by organism of signal transduction pathway in other organism during symbiotic interaction" RELATED []
synonym: "down-regulation by organism of signal transduction pathway in other organism during symbiotic interaction" RELATED []
synonym: "downregulation by organism of signal transduction pathway in other organism during symbiotic interaction" RELATED []
synonym: "inhibition by organism of signal transduction pathway in other organism during symbiotic interaction" NARROW []
synonym: "negative modulation by organism of other organism signal transduction pathway" RELATED []
synonym: "negative regulation by organism of signal transduction pathway in other organism during symbiotic interaction" RELATED [GOC:tb]
is_a: GO:0052250 ! modulation of signal transduction in other organism involved in symbiotic interaction

[Term]
id: GO:0052494
name: occlusion by host of symbiont vascular system
namespace: biological_process
def: "The process in which an organism reduces the flow of fluid within its symbiont's vascular system, the vessels and tissue that carry or circulate fluids, such as blood, lymph or sap, through the body of an animal or plant. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, http://www.thefreedictionary.com]
subset: gosubset_prok
is_a: GO:0052183 ! modification by host of symbiont structure
is_a: GO:0052495 ! occlusion by organism of vascular system in other organism involved in symbiotic interaction

[Term]
id: GO:0052495
name: occlusion by organism of vascular system in other organism involved in symbiotic interaction
namespace: biological_process
def: "The process in which an organism reduces the flow of fluid within its second organism's vascular system, the vessels and tissue that carry or circulate fluids, such as blood, lymph or sap, through the body of an animal or plant, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, http://www.thefreedictionary.com]
subset: gosubset_prok
synonym: "occlusion by organism of vascular system in other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0052185 ! modification of structure of other organism involved in symbiotic interaction

[Term]
id: GO:0052496
name: occlusion by host of symbiont xylem
namespace: biological_process
def: "The process in which an organism reduces the flow of fluid within the symbiont xylem, the tissue in plants that carries water and nutrients up from the roots to the shoot and leaves. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052494 ! occlusion by host of symbiont vascular system
is_a: GO:0052497 ! occlusion by organism of xylem in other organism involved in symbiotic interaction

[Term]
id: GO:0052497
name: occlusion by organism of xylem in other organism involved in symbiotic interaction
namespace: biological_process
def: "The process in which an organism reduces the flow of fluid within the xylem, the tissue in plants that carries water and nutrients up from the roots to the shoot and leaves, of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "occlusion by organism of xylem in other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0052495 ! occlusion by organism of vascular system in other organism involved in symbiotic interaction

[Term]
id: GO:0052498
name: obsolete pathogen-associated molecular pattern dependent induction by organism of symbiont innate immunity
namespace: biological_process
def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "general elicitor-dependent activation of symbiont innate immunity" EXACT []
synonym: "general elicitor-dependent induction of symbiont innate immunity" EXACT []
synonym: "MAMP dependent activation of symbiont innate immunity" EXACT []
synonym: "MAMP dependent induction of symbiont innate immunity" EXACT []
synonym: "PAMP dependent activation of symbiont innate immunity" EXACT []
synonym: "PAMP dependent induction of symbiont innate immunity" EXACT []
synonym: "pathogen-associated molecular pattern dependent activation by organism of symbiont innate immunity" EXACT []
synonym: "pathogen-associated molecular pattern dependent induction by organism of symbiont innate immunity" EXACT []
is_obsolete: true

[Term]
id: GO:0052499
name: obsolete pathogen-associated molecular pattern dependent modulation by organism of symbiont innate immunity
namespace: biological_process
def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "pathogen-associated molecular pattern dependent modulation by organism of symbiont innate immunity" EXACT []
is_obsolete: true

[Term]
id: GO:0052500
name: obsolete positive regulation by organism of symbiont apoptosis
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in the symbiont, where programmed cell death proceeds by apoptosis. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "positive regulation by organism of symbiont apoptosis" EXACT []
synonym: "positive regulation by organism of symbiont apoptotic programmed cell death" EXACT []
is_obsolete: true

[Term]
id: GO:0052501
name: positive regulation by organism of apoptotic process in other organism involved in symbiotic interaction
namespace: biological_process
alt_id: GO:0052388
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death by apoptosis in a second organism, where the two organisms are in a symbiotic interaction." [GOC:jl, GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of apoptosis in other organism during symbiotic interaction" NARROW []
synonym: "activation by organism of apoptotic programmed cell death in other organism during symbiotic interaction" RELATED []
synonym: "induction by organism of apoptosis in other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "induction by organism of apoptosis in other organism involved in symbiotic interaction" EXACT []
synonym: "induction by organism of apoptotic programmed cell death in other organism during symbiotic interaction" RELATED []
synonym: "positive regulation by organism of apoptosis in other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "positive regulation by organism of apoptosis in other organism involved in symbiotic interaction" NARROW []
synonym: "positive regulation by organism of apoptotic process in other organism involved in symbiotic interaction" NARROW []
synonym: "positive regulation by organism of apoptotic programmed cell death in other organism during symbiotic interaction" RELATED []
synonym: "stimulation by organism of apoptosis in other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of apoptosis in other organism during symbiotic interaction" RELATED []
synonym: "up-regulation by organism of apoptosis in other organism during symbiotic interaction" RELATED []
synonym: "upregulation by organism of apoptosis in other organism during symbiotic interaction" RELATED []
is_a: GO:0044533 ! positive regulation of apoptotic process in other organism
is_a: GO:0052042 ! positive regulation by symbiont of host programmed cell death
is_a: GO:0052433 ! modulation by organism of apoptotic process in other organism involved in symbiotic interaction

[Term]
id: GO:0052502
name: positive regulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of symbiont MAP kinase-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "activation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway" NARROW []
synonym: "activation by organism of defense-related symbiont MAP kinase-mediated signal transduction pathway" NARROW []
synonym: "induction by organism of defense-related symbiont MAP kinase-mediated signal transduction pathway" NARROW []
synonym: "positive regulation by organism of defense-related symbiont MAPK-mediated signal transduction pathway" EXACT []
synonym: "positive regulation by organism of defense-related symbiont mitogen-activated protein kinase-mediated signal transduction pathway" EXACT []
synonym: "stimulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway" NARROW []
synonym: "up regulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway" EXACT []
synonym: "up-regulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway" EXACT []
synonym: "upregulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway" EXACT []
synonym: "upregulation by organism of defense-related symbiont MAP kinase-mediated signal transduction pathway" NARROW []
is_a: GO:0052276 ! positive regulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism involved in symbiotic interaction
is_a: GO:0052435 ! modulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway
is_a: GO:0075100 ! positive regulation by host of symbiont protein kinase-mediated signal transduction

[Term]
id: GO:0052503
name: obsolete positive regulation by organism of defense-related symbiont calcium-dependent protein kinase pathway
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the symbiont calcium-dependent protein kinase pathway during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "positive regulation by organism of defense-related symbiont calcium-dependent protein kinase pathway" EXACT []
synonym: "positive regulation of defense-related symbiont CDPK pathway by organism" EXACT []
is_obsolete: true

[Term]
id: GO:0052504
name: obsolete positive regulation by organism of defense-related symbiont callose deposition
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of callose deposition by the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "induction by organism of defense-related papilla formation in symbiont" NARROW []
synonym: "induction by organism of defense-related symbiont callose deposition" NARROW []
synonym: "positive regulation by organism of defense-related papilla formation in symbiont" EXACT []
synonym: "positive regulation by organism of defense-related symbiont callose deposition" EXACT []
is_obsolete: true

[Term]
id: GO:0052505
name: obsolete positive regulation by organism of defense-related symbiont cell wall callose deposition
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the deposition of callose by the symbiont in its cell walls, occurring as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "induction by organism of defense-related symbiont cell wall callose deposition" NARROW []
synonym: "positive regulation by organism of defense-related symbiont cell wall callose deposition" EXACT []
is_obsolete: true

[Term]
id: GO:0052506
name: obsolete positive regulation by organism of defense-related symbiont ethylene-mediated signal transduction pathway
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of symbiont ethylene-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "activation by organism of defense-related symbiont ethylene-mediated signal transduction pathway" NARROW []
synonym: "induction by organism of defense-related symbiont ethylene-mediated signal transduction pathway" NARROW []
synonym: "positive regulation by organism of defense-related symbiont ethylene-mediated signal transduction pathway" EXACT []
synonym: "upregulation by organism of defense-related symbiont ethylene-mediated signal transduction pathway" NARROW []
is_obsolete: true

[Term]
id: GO:0052507
name: obsolete positive regulation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of symbiont jasmonic acid-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "activation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway" NARROW []
synonym: "activation by organism of defense-related symbiont SA-mediated signal transduction pathway" NARROW []
synonym: "induction by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway" NARROW []
synonym: "induction by organism of defense-related symbiont SA-mediated signal transduction pathway" NARROW []
synonym: "positive regulation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway" EXACT []
synonym: "positive regulation by organism of defense-related symbiont SA-mediated signal transduction pathway" EXACT []
synonym: "upregulation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway" NARROW []
synonym: "upregulation by organism of defense-related symbiont SA-mediated signal transduction pathway" NARROW []
is_obsolete: true

[Term]
id: GO:0052508
name: obsolete positive regulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of symbiont salicylic acid-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "activation by organism of defense-related symbiont SA-mediated signal transduction pathway" NARROW []
synonym: "activation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway" NARROW []
synonym: "induction by organism of defense-related symbiont SA-mediated signal transduction pathway" NARROW []
synonym: "induction by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway" NARROW []
synonym: "positive regulation by organism of defense-related symbiont SA-mediated signal transduction pathway" NARROW []
synonym: "positive regulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway" EXACT []
synonym: "upregulation by organism of defense-related symbiont SA-mediated signal transduction pathway" NARROW []
synonym: "upregulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway" NARROW []
is_obsolete: true

[Term]
id: GO:0052509
name: positive regulation by symbiont of host defense response
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by symbiont of host defense response" NARROW []
synonym: "stimulation by symbiont of host defense response" NARROW []
synonym: "up regulation by symbiont of host defense response" EXACT []
synonym: "up-regulation by symbiont of host defense response" EXACT []
synonym: "upregulation by symbiont of host defense response" EXACT []
is_a: GO:0052031 ! modulation by symbiont of host defense response
is_a: GO:0052510 ! positive regulation by organism of defense response of other organism involved in symbiotic interaction

[Term]
id: GO:0052510
name: positive regulation by organism of defense response of other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of defense response of other organism during symbiotic interaction" NARROW []
synonym: "positive regulation by organism of defense response of other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "stimulation by organism of defense response of other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of defense response of other organism during symbiotic interaction" RELATED []
synonym: "up-regulation by organism of defense response of other organism during symbiotic interaction" RELATED []
synonym: "upregulation by organism of defense response of other organism during symbiotic interaction" RELATED []
is_a: GO:0031349 ! positive regulation of defense response
is_a: GO:0052255 ! modulation by organism of defense response of other organism involved in symbiotic interaction

[Term]
id: GO:0052511
name: obsolete positive regulation by organism of symbiont ethylene-mediated defense response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the ethylene-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "activation by organism of symbiont ethylene-mediated defense response" NARROW []
synonym: "induction by organism of symbiont ethylene-mediated defense response" NARROW []
synonym: "positive regulation by organism of symbiont ethylene-mediated defense response" EXACT []
synonym: "upregulation by organism of symbiont ethylene-mediated defense response" NARROW []
is_obsolete: true

[Term]
id: GO:0052512
name: obsolete positive regulation by organism of hormone or growth regulator levels in symbiont
namespace: biological_process
def: "OBSOLETE. The increase by an organism of the levels of hormones or growth regulators in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "positive modulation of hormone or growth regulator levels in symbiont" EXACT []
synonym: "positive regulation by organism of hormone or growth regulator levels in symbiont" EXACT []
is_obsolete: true

[Term]
id: GO:0052513
name: positive regulation by organism of hormone or growth regulator levels in other organism involved in symbiotic interaction
namespace: biological_process
def: "The increase by an organism of the levels of hormones or growth regulators in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of hormone or growth regulator levels in other organism during symbiotic interaction" NARROW []
synonym: "positive modulation of hormone or growth regulator levels in other organism" EXACT []
synonym: "positive regulation by organism of hormone or growth regulator levels in other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "stimulation by organism of hormone or growth regulator levels in other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of hormone or growth regulator levels in other organism during symbiotic interaction" RELATED []
synonym: "up-regulation by organism of hormone or growth regulator levels in other organism during symbiotic interaction" RELATED []
synonym: "upregulation by organism of hormone or growth regulator levels in other organism during symbiotic interaction" RELATED []
is_a: GO:0052186 ! modulation by organism of hormone or growth regulator levels in other organism involved in symbiotic interaction

[Term]
id: GO:0052514
name: obsolete positive regulation by organism of symbiont inflammatory response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the inflammatory response of a symbiont organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "positive regulation by organism of symbiont inflammatory response" EXACT []
is_obsolete: true

[Term]
id: GO:0052515
name: obsolete positive regulation by organism of symbiont innate immunity
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the innate immune response of the symbiont organism; the innate immune response is the symbiont's first line of defense against infection. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "positive regulation by organism of symbiont innate immunity" EXACT []
synonym: "positive regulation of symbiont innate immune response" EXACT []
is_obsolete: true

[Term]
id: GO:0052516
name: obsolete positive regulation by organism of symbiont jasmonic acid-mediated defense response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the jasmonic acid-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "induction by organism of symbiont JA-mediated defense response" NARROW []
synonym: "induction by organism of symbiont jasmonic acid-mediated defense response" NARROW []
synonym: "positive regulation by organism of symbiont JA-mediated defense response" EXACT []
synonym: "positive regulation by organism of symbiont jasmonic acid-mediated defense response" EXACT []
is_obsolete: true

[Term]
id: GO:0052517
name: obsolete positive regulation by organism of symbiont non-apoptotic programmed cell death
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in the symbiont, where programmed cell death proceeds by a non-apoptotic pathway. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "positive regulation by organism of symbiont non-apoptotic programmed cell death" EXACT []
is_obsolete: true

[Term]
id: GO:0052519
name: positive regulation by host of nutrient release from symbiont
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the release of nutrients from a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "activation by host of nutrient release from symbiont" NARROW []
synonym: "promotion of nutrient release from symbiont" EXACT []
synonym: "stimulation by host of nutrient release from symbiont" NARROW []
synonym: "up regulation by host of nutrient release from symbiont" EXACT []
synonym: "up-regulation by host of nutrient release from symbiont" EXACT []
synonym: "upregulation by host of nutrient release from symbiont" EXACT []
is_a: GO:0052460 ! modulation by host of nutrient release from symbiont
is_a: GO:0052520 ! positive regulation by organism of nutrient release from other organism involved in symbiotic interaction

[Term]
id: GO:0052520
name: positive regulation by organism of nutrient release from other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the release of nutrients from a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of nutrient release from other organism during symbiotic interaction" NARROW []
synonym: "positive regulation by organism of nutrient release from other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "promotion of nutrient release from other organism" EXACT []
synonym: "stimulation by organism of nutrient release from other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of nutrient release from other organism during symbiotic interaction" RELATED []
synonym: "up-regulation by organism of nutrient release from other organism during symbiotic interaction" RELATED []
synonym: "upregulation by organism of nutrient release from other organism during symbiotic interaction" RELATED []
is_a: GO:0052313 ! modulation of nutrient release from other organism involved in symbiotic interaction

[Term]
id: GO:0052521
name: positive regulation by host of symbiont phagocytosis
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "activation by host of symbiont phagocytosis" NARROW []
synonym: "stimulation by host of symbiont phagocytosis" NARROW []
synonym: "up regulation by host of symbiont phagocytosis" EXACT []
synonym: "up-regulation by host of symbiont phagocytosis" EXACT []
synonym: "upregulation by host of symbiont phagocytosis" EXACT []
is_a: GO:0052462 ! modulation by host of symbiont phagocytosis
is_a: GO:0052522 ! positive regulation by organism of phagocytosis in other organism involved in symbiotic interaction

[Term]
id: GO:0052522
name: positive regulation by organism of phagocytosis in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in the second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "activation by organism of phagocytosis in other organism during symbiotic interaction" NARROW []
synonym: "positive regulation by organism of phagocytosis in other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "stimulation by organism of phagocytosis in other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of phagocytosis in other organism during symbiotic interaction" RELATED []
synonym: "up-regulation by organism of phagocytosis in other organism during symbiotic interaction" RELATED []
synonym: "upregulation by organism of phagocytosis in other organism during symbiotic interaction" RELATED []
is_a: GO:0050766 ! positive regulation of phagocytosis
is_a: GO:0052231 ! modulation of phagocytosis in other organism involved in symbiotic interaction

[Term]
id: GO:0052523
name: obsolete positive regulation by organism of symbiont programmed cell death
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "enhancement or induction of symbiont programmed cell death" EXACT []
synonym: "positive regulation by organism of symbiont programmed cell death" EXACT []
is_obsolete: true

[Term]
id: GO:0052524
name: obsolete positive regulation by organism of symbiont salicylic acid-mediated defense response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the salicylic acid-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "induction by organism of symbiont SA-mediated defense response" NARROW []
synonym: "induction by organism of symbiont salicylic acid-mediated defense response" NARROW []
synonym: "positive regulation by organism of symbiont SA-mediated defense response" EXACT []
synonym: "positive regulation by organism of symbiont salicylic acid-mediated defense response" EXACT []
is_obsolete: true

[Term]
id: GO:0052525
name: positive regulation by host of symbiont signal transduction pathway
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the symbiont signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "activation by host of symbiont signal transduction pathway" NARROW []
synonym: "stimulation by host of symbiont signal transduction pathway" NARROW []
synonym: "up regulation by host of symbiont signal transduction pathway" EXACT []
synonym: "up-regulation by host of symbiont signal transduction pathway" EXACT []
synonym: "upregulation by host of symbiont signal transduction pathway" EXACT []
is_a: GO:0052470 ! modulation by host of symbiont signal transduction pathway
is_a: GO:0052526 ! positive regulation by organism of signal transduction in other organism involved in symbiotic interaction

[Term]
id: GO:0052526
name: positive regulation by organism of signal transduction in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the second organism signal transduction pathways, the cascade of processes by which a signal interacts with a receptor, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of signal transduction pathway in other organism during symbiotic interaction" NARROW []
synonym: "positive regulation by organism of signal transduction pathway in other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "stimulation by organism of signal transduction pathway in other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of signal transduction pathway in other organism during symbiotic interaction" RELATED []
synonym: "up-regulation by organism of signal transduction pathway in other organism during symbiotic interaction" RELATED []
synonym: "upregulation by organism of signal transduction pathway in other organism during symbiotic interaction" RELATED []
is_a: GO:0044502 ! positive regulation of signal transduction in other organism
is_a: GO:0052250 ! modulation of signal transduction in other organism involved in symbiotic interaction

[Term]
id: GO:0052527
name: positive regulation by symbiont of host resistance gene-dependent defense response
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the resistance gene-dependent defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by symbiont of host resistance gene-dependent defense response" NARROW []
synonym: "positive regulation by organism of defense response in host by specific elicitors" EXACT []
synonym: "positive regulation by organism of host gene-for-gene resistance" EXACT []
synonym: "positive regulation by organism of pathogen-race/host plant cultivar-specific resistance in symbiont" EXACT []
synonym: "stimulation by symbiont of host resistance gene-dependent defense response" NARROW []
synonym: "up regulation by symbiont of host resistance gene-dependent defense response" EXACT []
synonym: "up-regulation by symbiont of host resistance gene-dependent defense response" EXACT []
synonym: "upregulation by symbiont of host resistance gene-dependent defense response" EXACT []
is_a: GO:0052158 ! modulation by symbiont of host resistance gene-dependent defense response
is_a: GO:0052423 ! positive regulation by organism of resistance gene-dependent defense response of other organism involved in symbiotic interaction
is_a: GO:0052556 ! positive regulation by symbiont of host immune response

[Term]
id: GO:0052528
name: obsolete upregulation by organism of symbiont programmed cell death
namespace: biological_process
def: "OBSOLETE. Any process by which an organism increases the frequency, rate or extent of programmed cell death in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "enhancement of symbiont programmed cell death by organism" EXACT []
synonym: "upregulation by organism of symbiont programmed cell death" EXACT []
is_obsolete: true

[Term]
id: GO:0052530
name: obsolete positive regulation by organism of symbiont resistance gene-dependent defense response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the resistance gene-dependent defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "positive regulation by organism of defense response in symbiont by specific elicitors" EXACT []
synonym: "positive regulation by organism of pathogen-race/symbiont plant cultivar-specific resistance in symbiont" EXACT []
synonym: "positive regulation by organism of symbiont gene-for-gene resistance" EXACT []
synonym: "positive regulation by organism of symbiont resistance gene-dependent defense response" EXACT []
is_obsolete: true

[Term]
id: GO:0052531
name: obsolete positive regulation by organism of defense-related symbiont calcium ion flux
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of fluxes of calcium ions that occur as part of the defense response of a host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "positive regulation by organism of defense-related symbiont Ca2+ flux" EXACT []
synonym: "positive regulation by organism of defense-related symbiont calcium ion flux" EXACT []
is_obsolete: true

[Term]
id: GO:0052532
name: positive regulation by organism of induced systemic resistance in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of induced systemic resistance, a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling, in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of induced systemic resistance in other organism during symbiotic interaction" NARROW []
synonym: "positive regulation by organism of induced systemic resistance in other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "stimulation by organism of induced systemic resistance in other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of induced systemic resistance in other organism during symbiotic interaction" RELATED []
synonym: "up-regulation by organism of induced systemic resistance in other organism during symbiotic interaction" RELATED []
synonym: "upregulation by organism of induced systemic resistance in other organism during symbiotic interaction" RELATED []
is_a: GO:0002833 ! positive regulation of response to biotic stimulus
is_a: GO:0052298 ! modulation by organism of induced systemic resistance in other organism involved in symbiotic interaction
is_a: GO:0052305 ! positive regulation by organism of innate immune response in other organism involved in symbiotic interaction

[Term]
id: GO:0052533
name: positive regulation by symbiont of host induced systemic resistance
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of induced systemic resistance in the host organism; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by symbiont of induced systemic resistance in host" NARROW []
synonym: "positive regulation by symbiont of induced systemic resistance in host" EXACT []
synonym: "stimulation by symbiont of induced systemic resistance in host" NARROW []
synonym: "up regulation by symbiont of induced systemic resistance in host" EXACT []
synonym: "up-regulation by symbiont of induced systemic resistance in host" EXACT []
synonym: "upregulation by symbiont of induced systemic resistance in host" EXACT []
is_a: GO:0052159 ! modulation by symbiont of host induced systemic resistance
is_a: GO:0052509 ! positive regulation by symbiont of host defense response
is_a: GO:0052532 ! positive regulation by organism of induced systemic resistance in other organism involved in symbiotic interaction
is_a: GO:0052556 ! positive regulation by symbiont of host immune response

[Term]
id: GO:0052534
name: obsolete positive regulation by organism of induced systemic resistance in symbiont
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of induced systemic resistance in the symbiont organism; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "positive regulation by organism of induced systemic resistance in symbiont" EXACT []
is_obsolete: true

[Term]
id: GO:0052535
name: positive regulation by organism of systemic acquired resistance in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of systemic acquired resistance organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance, in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of systemic acquired resistance in other organism during symbiotic interaction" NARROW []
synonym: "positive regulation by organism of systemic acquired resistance in other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "stimulation by organism of systemic acquired resistance in other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of systemic acquired resistance in other organism during symbiotic interaction" RELATED []
synonym: "up-regulation by organism of systemic acquired resistance in other organism during symbiotic interaction" RELATED []
synonym: "upregulation by organism of systemic acquired resistance in other organism during symbiotic interaction" RELATED []
is_a: GO:0002833 ! positive regulation of response to biotic stimulus
is_a: GO:0052299 ! modulation by organism of systemic acquired resistance in other organism involved in symbiotic interaction
is_a: GO:0052305 ! positive regulation by organism of innate immune response in other organism involved in symbiotic interaction

[Term]
id: GO:0052536
name: obsolete positive regulation by organism of systemic acquired resistance in symbiont
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of systemic acquired resistance in the symbiont organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "positive regulation by organism of systemic acquired resistance in symbiont" EXACT []
is_obsolete: true

[Term]
id: GO:0052537
name: positive regulation by symbiont of host systemic acquired resistance
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of systemic acquired resistance in the host organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by symbiont of systemic acquired resistance in host" NARROW []
synonym: "positive regulation by symbiont of systemic acquired resistance in host" EXACT []
synonym: "stimulation by symbiont of systemic acquired resistance in host" NARROW []
synonym: "up regulation by symbiont of systemic acquired resistance in host" EXACT []
synonym: "up-regulation by symbiont of systemic acquired resistance in host" EXACT []
synonym: "upregulation by symbiont of systemic acquired resistance in host" EXACT []
is_a: GO:0052160 ! modulation by symbiont of host systemic acquired resistance
is_a: GO:0052509 ! positive regulation by symbiont of host defense response
is_a: GO:0052535 ! positive regulation by organism of systemic acquired resistance in other organism involved in symbiotic interaction
is_a: GO:0052556 ! positive regulation by symbiont of host immune response

[Term]
id: GO:0052538
name: positive regulation by organism of defense-related cell wall thickening in other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the thickening of cell walls that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of defense-related cell wall thickening in other organism during symbiotic interaction" NARROW []
synonym: "positive regulation by organism of defense-related cell wall thickening in other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "positive regulation by organism of defensive cell wall thickening in other organism during symbiotic interaction" RELATED []
synonym: "stimulation by organism of defense-related cell wall thickening in other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of defense-related cell wall thickening in other organism during symbiotic interaction" RELATED []
synonym: "up-regulation by organism of defense-related cell wall thickening in other organism during symbiotic interaction" RELATED []
synonym: "upregulation by organism of defense-related cell wall thickening in other organism during symbiotic interaction" RELATED []
is_a: GO:0052300 ! modulation by organism of defense-related cell wall thickening in other organism involved in symbiotic interaction
is_a: GO:0052510 ! positive regulation by organism of defense response of other organism involved in symbiotic interaction

[Term]
id: GO:0052539
name: positive regulation by symbiont of defense-related host cell wall thickening
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of a host process resulting in the thickening of its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by symbiont of defense-related host cell wall thickening" NARROW []
synonym: "positive regulation by organism of host defensive cell wall thickening" EXACT []
synonym: "stimulation by symbiont of defense-related host cell wall thickening" NARROW []
synonym: "up regulation by symbiont of defense-related host cell wall thickening" EXACT []
synonym: "up-regulation by symbiont of defense-related host cell wall thickening" EXACT []
synonym: "upregulation by symbiont of defense-related host cell wall thickening" EXACT []
is_a: GO:0052161 ! modulation by symbiont of defense-related host cell wall thickening
is_a: GO:0052509 ! positive regulation by symbiont of host defense response
is_a: GO:0052538 ! positive regulation by organism of defense-related cell wall thickening in other organism involved in symbiotic interaction

[Term]
id: GO:0052540
name: obsolete positive regulation by organism of defense-related symbiont cell wall thickening
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of symbiont processes resulting in the thickening of its cell walls, occurring as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "positive regulation by organism of defense-related symbiont cell wall thickening" EXACT []
synonym: "positive regulation by organism of symbiont defensive cell wall thickening" EXACT []
is_obsolete: true

[Term]
id: GO:0052541
name: plant-type cell wall cellulose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, as part of the organization and biogenesis of the cell wall." [GOC:mah, ISBN:0198506732]
synonym: "cell wall cellulose metabolism" EXACT []
synonym: "cellulose and pectin-containing cell wall cellulose metabolic process" EXACT []
is_a: GO:0010383 ! cell wall polysaccharide metabolic process
is_a: GO:0030243 ! cellulose metabolic process
relationship: part_of GO:0009664 ! plant-type cell wall organization

[Term]
id: GO:0052542
name: defense response by callose deposition
namespace: biological_process
def: "Any process in which callose is transported to, and/or maintained in, a specific location during the defense response. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls." [GOC:mtg_pamgo_17jul06]
synonym: "callose deposition during defense response" RELATED [GOC:dph]
synonym: "callose localization during defense response" RELATED []
is_a: GO:0006952 ! defense response
is_a: GO:0052545 ! callose localization

[Term]
id: GO:0052543
name: callose deposition in cell wall
namespace: biological_process
def: "Any process in which callose is transported to, and/or maintained in, the cell wall. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls." [GOC:mtg_pamgo_17jul06]
synonym: "callose localization in cell wall" EXACT []
synonym: "cell wall callose deposition" EXACT []
synonym: "cell wall callose localization" EXACT []
is_a: GO:0052386 ! cell wall thickening
is_a: GO:0052545 ! callose localization
is_a: GO:0070727 ! cellular macromolecule localization

[Term]
id: GO:0052544
name: defense response by callose deposition in cell wall
namespace: biological_process
def: "Any process in which callose is transported to, and/or maintained in, the cell wall during the defense response. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls." [GOC:mtg_pamgo_17jul06]
synonym: "callose deposition in cell wall during defense response" RELATED [GOC:dph]
synonym: "callose localization in cell wall during defense response" EXACT []
synonym: "cell wall callose deposition during defense response" EXACT []
synonym: "cell wall callose localization during defense response" EXACT []
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0052482 ! defense response by cell wall thickening
is_a: GO:0052542 ! defense response by callose deposition
is_a: GO:0052543 ! callose deposition in cell wall
is_a: GO:1902580 ! single-organism cellular localization
intersection_of: GO:0052543 ! callose deposition in cell wall
intersection_of: part_of GO:0006952 ! defense response
relationship: part_of GO:0006952 ! defense response

[Term]
id: GO:0052545
name: callose localization
namespace: biological_process
def: "Any process in which callose is transported to, and/or maintained in, a specific location. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls." [GOC:mtg_pamgo_17jul06, http://www.onelook.com]
synonym: "callose localisation" EXACT [GOC:mah]
is_a: GO:0033037 ! polysaccharide localization

[Term]
id: GO:0052546
name: cell wall pectin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues, as part of the organization and biogenesis of the cell wall." [GOC:ai]
synonym: "cell wall pectin metabolism" EXACT []
synonym: "cellulose and pectin-containing cell wall pectin metabolic process" EXACT []
synonym: "pectin metabolism during cell wall biogenesis" EXACT []
synonym: "plant-type cell wall pectin metabolic process" EXACT []
is_a: GO:0045488 ! pectin metabolic process
relationship: part_of GO:0009664 ! plant-type cell wall organization

[Term]
id: GO:0052547
name: regulation of peptidase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins." [EC:3.4, GOC:ai]
synonym: "peptidase regulator activity" RELATED []
is_a: GO:0030162 ! regulation of proteolysis
is_a: GO:0051336 ! regulation of hydrolase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008233 ! peptidase activity
relationship: regulates GO:0008233 ! peptidase activity

[Term]
id: GO:0052548
name: regulation of endopeptidase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins." [GOC:ai, GOC:hjd]
synonym: "protease regulator activity" NARROW []
is_a: GO:0052547 ! regulation of peptidase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004175 ! endopeptidase activity
relationship: regulates GO:0004175 ! endopeptidase activity

[Term]
id: GO:0052549
name: response to phytoalexin production by other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of phytoalexins produced as a defense response by a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "response to phytoalexin production by other organism during symbiotic interaction" RELATED [GOC:tb]
is_a: GO:0052564 ! response to immune response of other organism involved in symbiotic interaction

[Term]
id: GO:0052550
name: response to defense-related reactive oxygen species production by other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of reactive oxygen species produced as a defense response by a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "response to defense-related reactive oxygen species production by other organism during symbiotic interaction" RELATED [GOC:tb]
is_a: GO:0052564 ! response to immune response of other organism involved in symbiotic interaction

[Term]
id: GO:0052551
name: response to defense-related nitric oxide production by other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of nitric oxide produced as a defense response by a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "response to defense-related nitric oxide production by other organism during symbiotic interaction" RELATED [GOC:tb]
is_a: GO:0052564 ! response to immune response of other organism involved in symbiotic interaction

[Term]
id: GO:0052552
name: modulation by organism of immune response of other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of the immune response of a second organism, where the two organisms are in a symbiotic interaction. The immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of immune response of other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0050776 ! regulation of immune response
is_a: GO:0052255 ! modulation by organism of defense response of other organism involved in symbiotic interaction
is_a: GO:0052564 ! response to immune response of other organism involved in symbiotic interaction

[Term]
id: GO:0052553
name: modulation by symbiont of host immune response
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of the immune response of the host organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052031 ! modulation by symbiont of host defense response
is_a: GO:0052552 ! modulation by organism of immune response of other organism involved in symbiotic interaction
is_a: GO:0052572 ! response to host immune response

[Term]
id: GO:0052554
name: obsolete modulation by organism of symbiont immune response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the immune response of the symbiont organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of symbiont immune response" EXACT []
is_obsolete: true

[Term]
id: GO:0052555
name: positive regulation by organism of immune response of other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the immune response of a second organism, where the two organisms are in a symbiotic interaction. The immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of immune response of other organism during symbiotic interaction" NARROW []
synonym: "positive regulation by organism of immune response of other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "stimulation by organism of immune response of other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of immune response of other organism during symbiotic interaction" RELATED []
synonym: "up-regulation by organism of immune response of other organism during symbiotic interaction" RELATED []
synonym: "upregulation by organism of immune response of other organism during symbiotic interaction" RELATED []
is_a: GO:0050778 ! positive regulation of immune response
is_a: GO:0052552 ! modulation by organism of immune response of other organism involved in symbiotic interaction

[Term]
id: GO:0052556
name: positive regulation by symbiont of host immune response
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the immune response of the host organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by symbiont of host immune response" NARROW []
synonym: "stimulation by symbiont of host immune response" NARROW []
synonym: "up regulation by symbiont of host immune response" EXACT []
synonym: "up-regulation by symbiont of host immune response" EXACT []
synonym: "upregulation by symbiont of host immune response" EXACT []
is_a: GO:0052553 ! modulation by symbiont of host immune response
is_a: GO:0052555 ! positive regulation by organism of immune response of other organism involved in symbiotic interaction

[Term]
id: GO:0052557
name: obsolete positive regulation by organism of symbiont immune response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the immune response of the symbiont organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "positive regulation by organism of symbiont immune response" EXACT []
is_obsolete: true

[Term]
id: GO:0052558
name: induction by organism of immune response of other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism activates the immune response of a second organism, where the two organisms are in a symbiotic interaction. The immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of immune response of other organism during symbiotic interaction" EXACT []
synonym: "induction by organism of immune response of other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0052555 ! positive regulation by organism of immune response of other organism involved in symbiotic interaction

[Term]
id: GO:0052559
name: induction by symbiont of host immune response
namespace: biological_process
def: "Any process in which an organism activates the immune response of the host organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052556 ! positive regulation by symbiont of host immune response
is_a: GO:0052558 ! induction by organism of immune response of other organism involved in symbiotic interaction

[Term]
id: GO:0052560
name: obsolete induction by organism of symbiont immune response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates the immune response of the symbiont organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "induction by organism of symbiont immune response" EXACT []
is_obsolete: true

[Term]
id: GO:0052561
name: negative regulation by organism of immune response of other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the immune response of a second organism, where the two organisms are in a symbiotic interaction. The immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by organism of immune response of other organism during symbiotic interaction" RELATED []
synonym: "down-regulation by organism of immune response of other organism during symbiotic interaction" RELATED []
synonym: "downregulation by organism of immune response of other organism during symbiotic interaction" RELATED []
synonym: "inhibition by organism of immune response of other organism during symbiotic interaction" NARROW []
synonym: "negative regulation by organism of immune response of other organism during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0050777 ! negative regulation of immune response
is_a: GO:0052552 ! modulation by organism of immune response of other organism involved in symbiotic interaction

[Term]
id: GO:0052562
name: negative regulation by symbiont of host immune response
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the immune response of the host organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by symbiont of host immune response" EXACT []
synonym: "down-regulation by symbiont of host immune response" EXACT []
synonym: "downregulation by symbiont of host immune response" EXACT []
synonym: "inhibition by symbiont of host immune response" NARROW []
is_a: GO:0052553 ! modulation by symbiont of host immune response
is_a: GO:0052561 ! negative regulation by organism of immune response of other organism involved in symbiotic interaction

[Term]
id: GO:0052563
name: obsolete negative regulation by organism of symbiont immune response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the immune response of the symbiont organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "negative regulation by organism of symbiont immune response" EXACT []
is_obsolete: true

[Term]
id: GO:0052564
name: response to immune response of other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the immune response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "response to immune response of other organism during symbiotic interaction" RELATED [gOC:dph]
is_a: GO:0052173 ! response to defenses of other organism involved in symbiotic interaction

[Term]
id: GO:0052565
name: response to defense-related host nitric oxide production
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of nitric oxide produced as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0052551 ! response to defense-related nitric oxide production by other organism involved in symbiotic interaction
is_a: GO:0052572 ! response to host immune response

[Term]
id: GO:0052566
name: response to host phytoalexin production
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of phytoalexins produced as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0052549 ! response to phytoalexin production by other organism involved in symbiotic interaction
is_a: GO:0052572 ! response to host immune response

[Term]
id: GO:0052567
name: response to defense-related host reactive oxygen species production
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of reactive oxygen species produced as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0052550 ! response to defense-related reactive oxygen species production by other organism involved in symbiotic interaction
is_a: GO:0052572 ! response to host immune response

[Term]
id: GO:0052568
name: obsolete response to symbiont phytoalexin production
namespace: biological_process
def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of phytoalexins produced as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "response to symbiont phytoalexin production" EXACT []
is_obsolete: true

[Term]
id: GO:0052569
name: obsolete response to defense-related symbiont nitric oxide production
namespace: biological_process
def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of nitric oxide produced as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "response to defense-related symbiont nitric oxide production" EXACT []
is_obsolete: true

[Term]
id: GO:0052570
name: obsolete response to defense-related symbiont reactive oxygen species production
namespace: biological_process
def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of reactive oxygen species produced as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "response to defense-related symbiont reactive oxygen species production" EXACT []
is_obsolete: true

[Term]
id: GO:0052571
name: obsolete response to symbiont immune response
namespace: biological_process
def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the immune response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "response to symbiont immune response" EXACT []
is_obsolete: true

[Term]
id: GO:0052572
name: response to host immune response
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052200 ! response to host defenses
is_a: GO:0052564 ! response to immune response of other organism involved in symbiotic interaction

[Term]
id: GO:0052573
name: UDP-D-galactose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving UDP-D-galactose, a substance composed of D-galactose in glycosidic linkage with guanosine diphosphate." [GOC:ai]
synonym: "UDP-D-galactopyranose metabolic process" EXACT [MetaCyc:UDP-GALACTOSE]
synonym: "UDP-D-galactopyranose metabolism" EXACT [MetaCyc:UDP-GALACTOSE]
synonym: "UDP-D-galactose metabolism" EXACT [MetaCyc:UDP-GALACTOSE]
synonym: "UDP-galactose metabolic process" EXACT [MetaCyc:UDP-GALACTOSE]
synonym: "UDP-galactose metabolism" EXACT [MetaCyc:UDP-GALACTOSE]
synonym: "uridine diphosphate galactose metabolic process" EXACT [MetaCyc:UDP-GALACTOSE]
synonym: "uridine diphosphate galactose metabolism" EXACT [MetaCyc:UDP-GALACTOSE]
is_a: GO:0009225 ! nucleotide-sugar metabolic process
creation_date: 2010-07-23T03:29:57Z

[Term]
id: GO:0052574
name: UDP-D-galactose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways involving UDP-D-galactose, a substance composed of D-galactose in glycosidic linkage with guanosine diphosphate." [GOC:ai]
synonym: "UDP-D-galactopyranose biosynthesis" EXACT [MetaCyc:UDP-GALACTOSE]
synonym: "UDP-D-galactopyranose biosynthetic process" EXACT [MetaCyc:UDP-GALACTOSE]
synonym: "UDP-D-galactose biosynthesis" EXACT [MetaCyc:UDP-GALACTOSE]
synonym: "UDP-galactose biosynthesis" EXACT [MetaCyc:UDP-GALACTOSE]
synonym: "UDP-galactose biosynthetic process" EXACT [MetaCyc:UDP-GALACTOSE]
synonym: "uridine diphosphate galactose biosynthesis" EXACT [MetaCyc:UDP-GALACTOSE]
synonym: "uridine diphosphate galactose biosynthetic process" EXACT [MetaCyc:UDP-GALACTOSE]
is_a: GO:0009226 ! nucleotide-sugar biosynthetic process
is_a: GO:0052573 ! UDP-D-galactose metabolic process
creation_date: 2010-07-23T03:52:40Z

[Term]
id: GO:0052575
name: carbohydrate localization
namespace: biological_process
def: "Any process in which a carbohydrate is transported to, or maintained in, a specific location. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [CHEBI:23008, GOC:mah]
subset: gosubset_prok
synonym: "carbohydrate localisation" EXACT [GOC:mah]
is_a: GO:0033036 ! macromolecule localization
creation_date: 2010-07-23T04:08:13Z

[Term]
id: GO:0052576
name: carbohydrate storage
namespace: biological_process
def: "The accumulation and maintenance in cells or tissues of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [CHEBI:23008, GOC:ai]
is_a: GO:0052575 ! carbohydrate localization
creation_date: 2010-07-23T04:16:56Z

[Term]
id: GO:0052577
name: germacrene-D synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (-)-germacrene D + diphosphate." [EC:4.2.3.22]
synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase [(-)-Germacrene D-forming] activity" EXACT [EC:4.2.3.22]
xref: EC:4.2.3.22
xref: KEGG:R07648
xref: MetaCyc:RXN-8562
is_a: GO:0010334 ! sesquiterpene synthase activity
created_by: gwg
creation_date: 2010-08-09T01:39:02Z

[Term]
id: GO:0052578
name: alpha-farnesene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (E,E)-alpha-farnesene + diphosphate." [MetaCyc:RXN-8574]
synonym: "(E,E)-alpha-farnesene synthase activity" EXACT [MetaCyc:RXN-8574]
xref: MetaCyc:RXN-8574
is_a: GO:0010334 ! sesquiterpene synthase activity
created_by: gwg
creation_date: 2010-08-09T01:39:42Z

[Term]
id: GO:0052579
name: (+)-pulegone reductase, (+)-isomenthone as substrate, activity
namespace: molecular_function
def: "Catalysis of the reaction: (+)-isomenthone + NADP+ = (+)-pulegone + NADPH + H+." [EC:1.3.1.81, MetaCyc:RXN-5164]
synonym: "(+)-isomenthone:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.81]
xref: EC:1.3.1.81
xref: MetaCyc:RXN-5164
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
created_by: gwg
creation_date: 2010-08-09T04:28:00Z

[Term]
id: GO:0052580
name: (+)-pulegone reductase, (-)-menthone as substrate, activity
namespace: molecular_function
def: "Catalysis of the reaction: (-)-menthone + NADP+ = (+)-pulegone + NADPH + H+." [EC:1.3.1.81, MetaCyc:RXN-5163]
synonym: "(-)-menthone:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.81]
xref: EC:1.3.1.81
xref: MetaCyc:RXN-5164
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
created_by: gwg
creation_date: 2010-08-09T04:33:53Z

[Term]
id: GO:0052581
name: (-)-isopiperitenone reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (6R)-isoperitenone + H(+) + NADPH = (2R,5R)-isopulegone + NADP(+)." [EC:1.3.1.82, RHEA:25651]
synonym: "(+)-cis-isopulegone:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.82]
xref: EC:1.3.1.82
xref: KEGG:R06417
xref: MetaCyc:RXN-5161
xref: RHEA:25651
is_a: GO:0035671 ! enone reductase activity
created_by: gwg
creation_date: 2010-08-09T04:42:05Z

[Term]
id: GO:0052582
name: (+)-menthofuran synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-pulegone + H(+) + NADPH + O(2) = (R)-menthofuran + 2 H(2)O + NADP(+)." [EC:1.14.13.104, RHEA:25661]
synonym: "(+)-MFS activity" BROAD [EC:1.14.13.104]
synonym: "(+)-pulegone 9-hydroxylase activity" EXACT [EC:1.14.13.104]
synonym: "(+)-pulegone,NADPH:oxygen oxidoreductase (9-hydroxylating) activity" EXACT [EC:1.14.13.104]
synonym: "cytochrome P450 menthofuran synthase activity" EXACT [EC:1.14.13.104]
synonym: "menthofuran synthase activity" EXACT [EC:1.14.13.104]
xref: EC:1.14.13.104
xref: KEGG:R08923
xref: MetaCyc:1.14.13.104-RXN
xref: RHEA:25661
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
created_by: gwg
creation_date: 2010-08-09T04:47:42Z

[Term]
id: GO:0052583
name: oxidoreductase activity, acting on halogen in donors
namespace: molecular_function
def: "Catalysis of an oxidation-reduction in which a halogen in the donor substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:mah]
xref: EC:1.22
is_a: GO:0016491 ! oxidoreductase activity
creation_date: 2010-08-13T10:14:12Z

[Term]
id: GO:0052584
name: oxidoreductase activity, acting on halogen in donors, with NAD or NADP as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction in which a halogen in the donor substance acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:mah]
xref: EC:1.22.1
is_a: GO:0052583 ! oxidoreductase activity, acting on halogen in donors
created_by: gwg
creation_date: 2010-08-13T10:17:56Z

[Term]
id: GO:0052585
name: oxidoreductase activity, acting on the CH-NH2 group of donors, with a quinone or similar compound as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a quinone or similar compound." [GOC:ai]
subset: gosubset_prok
xref: EC:1.4.5
is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors
creation_date: 2010-08-13T10:29:06Z

[Term]
id: GO:0052586
name: oxidoreductase activity, acting on other nitrogenous compounds as donors, with a quinone or similar compound as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a quinone or similar compound." [GOC:jl]
xref: EC:1.7.5
is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors
created_by: gwg
creation_date: 2010-08-13T10:34:37Z

[Term]
id: GO:0052587
name: diacetyl reductase ((R)-acetoin forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-acetoin + NAD(+) = diacetyl + H(+) + NADH." [EC:1.1.1.303, RHEA:22903]
synonym: "(R)-acetoin dehydrogenase activity" EXACT [EC:1.1.1.303]
xref: EC:1.1.1.303
xref: KEGG:R02855
xref: MetaCyc:RXN-11036
xref: RHEA:22903
is_a: GO:0019152 ! acetoin dehydrogenase activity

[Term]
id: GO:0052588
name: diacetyl reductase ((S)-acetoin forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-acetoin + NAD(+) = diacetyl + H(+) + NADH." [EC:1.1.1.304, RHEA:27289]
synonym: "(S)-acetoin dehydrogenase activity" EXACT [EC:1.1.1.304]
xref: EC:1.1.1.304
xref: KEGG:R09078
xref: MetaCyc:RXN-11032
xref: RHEA:27289
is_a: GO:0019152 ! acetoin dehydrogenase activity

[Term]
id: GO:0052589
name: malate dehydrogenase (menaquinone) activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-malate + a menaquinone = oxaloacetate + a menaquinol." [MetaCyc:RXNI-3]
synonym: "(S)-malate:(menaquinone) oxidoreductase activity" EXACT [EC:1.1.5.4]
synonym: "(S)-malate:menaquinone oxidoreductase activity" EXACT [EC:1.1.5.4]
xref: EC:1.1.5.4
xref: MetaCyc:RXNI-3
is_a: GO:0016615 ! malate dehydrogenase activity
is_a: GO:0016901 ! oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor

[Term]
id: GO:0052590
name: sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: sn-glycerol 3-phosphate + a ubiquinone = glycerone phosphate + a ubiquinol." [MetaCyc:RXN0-5258]
comment: Note that enzymes classified as EC:1.1.5.3 have several activities. They should be annotated with the terms GO:0004368, GO:0052590 and GO:0052591.
subset: gosubset_prok
xref: EC:1.1.5.3
xref: MetaCyc:RXN0-5258
is_a: GO:0004368 ! glycerol-3-phosphate dehydrogenase activity

[Term]
id: GO:0052591
name: sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: sn-glycerol 3-phosphate + ubiquinone-8 = glycerone phosphate + ubiquinol-8." [MetaCyc:GLYC3PDEHYDROG-RXN]
comment: Note that enzymes classified as EC:1.1.5.3 have several activities. They should be annotated with the terms GO:0004368, GO:0052590 and GO:0052591.
subset: gosubset_prok
xref: EC:1.1.5.3
xref: MetaCyc:GLYC3PDEHYDROG-RXN
is_a: GO:0052590 ! sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity

[Term]
id: GO:0052592
name: oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:ai]
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulphur protein as acceptor" EXACT []
xref: EC:1.17.7
is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups

[Term]
id: GO:0052593
name: tryptamine:oxygen oxidoreductase (deaminating) activity
namespace: molecular_function
def: "Catalysis of the reaction: tryptamine + H2O + O2 = NH3 + indole acetaldehyde + hydrogen peroxide + H+." [MetaCyc:RXN-1401]
xref: EC:1.4.3.21
xref: KEGG:R02173
xref: MetaCyc:RXN-1401
is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

[Term]
id: GO:0052594
name: aminoacetone:oxygen oxidoreductase(deaminating) activity
namespace: molecular_function
def: "Catalysis of the reaction: aminoacetone + H2O + O2 = methylglyoxal + NH3 + hydrogen peroxide + H+." [MetaCyc:AMACETOXID-RXN]
xref: EC:1.4.3.21
xref: KEGG:R02529
xref: MetaCyc:AMACETOXID-RXN
is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

[Term]
id: GO:0052595
name: aliphatic-amine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: an aliphatic amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide + H+." [MetaCyc:AMINEOXID-RXN]
synonym: "aliphatic-amine:oxygen oxidoreductase(deaminating) activity" EXACT []
xref: EC:1.4.3.21
xref: MetaCyc:AMINEOXID-RXN
xref: RHEA:16156
is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

[Term]
id: GO:0052596
name: phenethylamine:oxygen oxidoreductase (deaminating) activity
namespace: molecular_function
def: "Catalysis of the reaction: phenylethylamine + O2 + H2O = phenylacetaldehyde + NH3 + hydrogen peroxide + H+." [MetaCyc:AMINEPHEN-RXN]
xref: EC:1.4.3.21
xref: KEGG:R02613
xref: MetaCyc:AMINEPHEN-RXN
xref: RHEA:25268
is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

[Term]
id: GO:0052597
name: diamine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a diamine + H2O + O2 = a monoamine + NH3 + hydrogen peroxide." [MetaCyc:RXN-9599]
synonym: "diamine:oxygen oxidoreductase (deaminating) activity" EXACT systematic_synonym [EC:1.4.3.22]
xref: EC:1.4.3.22
xref: MetaCyc:RXN-9599
is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

[Term]
id: GO:0052598
name: histamine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: histamine + H2O + O2 = imidazole-4-acetaldehyde + NH3 + hydrogen peroxide + H+." [MetaCyc:RXN-9600]
synonym: "1H-Imidazole-4-ethanamine oxidase activity" EXACT [KEGG:R02150]
synonym: "1H-Imidazole-4-ethanamine:oxygen oxidoreductase (deaminating) activity" EXACT [KEGG:R02150]
synonym: "histamine:oxygen oxidoreductase (deaminating) activity" EXACT systematic_synonym [EC:1.4.3.22]
xref: EC:1.4.3.22
xref: KEGG:R02150
xref: MetaCyc:RXN-9600
xref: RHEA:25628
is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

[Term]
id: GO:0052599
name: methylputrescine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-methylputrescine + H2O + O2 = N-methylaminobutanal + NH3 + hydrogen peroxide + H+." [MetaCyc:RXN-8244]
synonym: "N-methylputrescine:oxygen oxidoreductase (deaminating) activity" EXACT systematic_synonym [EC:1.4.3.22]
xref: EC:1.4.3.22
xref: KEGG:R05334
xref: MetaCyc:RXN-8244
is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

[Term]
id: GO:0052600
name: propane-1,3-diamine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: propane-1,3-diamine + H2O + O2 = 3-aminopropanal + NH3 + hydrogen peroxide + H+." [MetaCyc:RXN-6381]
synonym: "1,3-diaminopropane oxidase activity" EXACT [KEGG:C00986]
synonym: "propane-1,3-diamine:oxygen oxidoreductase (deaminating) activity" EXACT systematic_synonym [EC:1.4.3.22]
synonym: "trimethylenediamine oxidase activity" EXACT [CHEBI:15725]
xref: EC:1.4.3.22
xref: KEGG:R03139
xref: MetaCyc:RXN-6381
is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

[Term]
id: GO:0052601
name: (S)-limonene 1,2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (4S)-limonene + NAD(P)H + H+ + O2 = NAD(P)+ + H2O + (4S)-limonene-1,2-epoxide." [MetaCyc:RXN-9409]
synonym: "(-)-limonene 1,2-monooxygenase activity" EXACT [EC:1.14.13.107]
synonym: "(-)-limonene,NAD(P)H:oxygen oxidoreductase activity" EXACT [EC:1.14.13.107]
synonym: "(S)-limonene,NAD(P)H:oxygen oxidoreductase activity" EXACT systematic_synonym [EC:1.14.13.107]
xref: EC:1.14.13.107
xref: KEGG:R09385 "(S)-limonene,NADH:oxygen oxidoreductase"
xref: KEGG:R09389 "(S)-limonene,NADPH:oxygen oxidoreductase"
xref: MetaCyc:RXN-9409
xref: RHEA:26088 "(S)-limonene,NADPH:oxygen oxidoreductase"
xref: RHEA:26092 "(S)-limonene,NADH:oxygen oxidoreductase"
is_a: GO:0019113 ! limonene monooxygenase activity

[Term]
id: GO:0052602
name: 4-chloronitrobenzene nitroreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-chloronitrobenzene + NADPH + H+ = 1-chloro-4-nitrosobenzene + NADP+ + H2O." [MetaCyc:RXN-8833]
xref: MetaCyc:RXN-8833
xref: UM-BBD_enzymeID:e0245
is_a: GO:0016657 ! oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor

[Term]
id: GO:0052603
name: 1-chloro-4-nitrosobenzene nitroreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-chloro-4-nitrosobenzene + NADPH + H+ = 1-chloro-4-hydroxylaminobenzene + NADP+ + H2O." [MetaCyc:RXN-8834]
xref: MetaCyc:RXN-8834
xref: UM-BBD_enzymeID:e0245
is_a: GO:0016657 ! oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor

[Term]
id: GO:0052604
name: delta-tocopherol cyclase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-methyl-6-phytyl-1,4-benzoquinone = delta-tocopherol." [MetaCyc:RXN-2561, PMID:12213958]
xref: KEGG:R07503
xref: MetaCyc:RXN-2561
is_a: GO:0009975 ! cyclase activity

[Term]
id: GO:0052605
name: gamma-tocopherol cyclase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-dimethyl-6-phytyl-1,4-benzoquinone = gamma-tocopherol." [MetaCyc:RXN-2543, PMID:12213958]
xref: KEGG:R07502
xref: MetaCyc:RXN-2543
is_a: GO:0009975 ! cyclase activity

[Term]
id: GO:0052606
name: chlorophyllide a oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: chlorophyllide a + NADPH + O2 + 2 H+ = 7-hydroxychlorophyllide a + NADP+ + H2O." [EC:1.13.12.14, MetaCyc:RXN-7676]
synonym: "CAO activity" BROAD [EC:1.13.12.14]
synonym: "chlorophyll a oxygenase activity" EXACT []
synonym: "chlorophyllide a:oxygen 7-oxidoreductase activity" EXACT [EC:1.13.12.14]
synonym: "chlorophyllide-a oxygenase activity" EXACT [EC:1.13.12.14]
xref: KEGG:R08203
xref: MetaCyc:RXN-7676
xref: RHEA:22679
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)
relationship: part_of GO:0010277 ! chlorophyllide a oxygenase [overall] activity

[Term]
id: GO:0052607
name: 7-hydroxy-chlorophyllide a oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7-hydroxychlorophyllide a + NADPH + O2 + H+ = chlorophyllide b + NADP+ + 2 H2O." [EC:1.13.12.14, MetaCyc:RXN-7677]
synonym: "7-hydroxychlorophyllide a:oxygen 7-oxidoreductase activity" EXACT [EC:1.13.12.14]
synonym: "7-hydroxychlorophyllide-a oxygenase activity" EXACT [EC:1.13.12.14]
synonym: "CAO activity" BROAD [EC:1.13.12.14]
synonym: "chlorophyll b synthetase activity" EXACT []
synonym: "chlorophyll-b synthase activity" EXACT [EC:1.13.12.14]
xref: KEGG:R08204
xref: MetaCyc:RXN-7677
xref: RHEA:22139
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)
relationship: part_of GO:0010277 ! chlorophyllide a oxygenase [overall] activity

[Term]
id: GO:0052608
name: echinenone 3-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: echinenone + a reduced electron acceptor + oxygen = 3-hydroxyechinenone + an oxidized electron acceptor + H2O." [MetaCyc:RXN-8214]
synonym: "beta-carotene hydroxylase activity" BROAD []
synonym: "beta-ring carotenoid 3-hydroxylase activity" BROAD [MetaCyc:MONOMER-12386]
synonym: "carotene beta-ring hydroxylase activity" BROAD []
xref: EC:1.14.99.-
xref: MetaCyc:RXN-8214
is_a: GO:0004497 ! monooxygenase activity

[Term]
id: GO:0052609
name: 4-ketotorulene 3-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-ketotorulene + a reduced electron acceptor + oxygen = 3-hydroxy-4-ketotorulene + an oxidized electron acceptor + H2O." [MetaCyc:RXN-8218]
synonym: "beta-carotene hydroxylase activity" BROAD []
synonym: "beta-ring carotenoid 3-hydroxylase activity" BROAD [MetaCyc:MONOMER-12386]
synonym: "carotene beta-ring hydroxylase activity" BROAD []
xref: EC:1.14.99.-
xref: MetaCyc:RXN-8218
is_a: GO:0004497 ! monooxygenase activity

[Term]
id: GO:0052610
name: beta-cryptoxanthin hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-cryptoxanthin + a reduced electron acceptor + oxygen = zeaxanthin + an oxidized electron acceptor + H2O." [MetaCyc:RXN-8026]
synonym: "beta-carotene hydroxylase activity" BROAD []
synonym: "beta-ring carotenoid 3-hydroxylase activity" BROAD [MetaCyc:MONOMER-12386]
synonym: "carotene beta-ring hydroxylase activity" BROAD []
xref: EC:1.14.99.-
xref: MetaCyc:RXN-8026
is_a: GO:0004497 ! monooxygenase activity

[Term]
id: GO:0052611
name: beta-carotene 3-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-carotene + a reduced electron acceptor + oxygen = beta-cryptoxanthin + an oxidized electron acceptor + H2O." [MetaCyc:RXN-8025]
synonym: "beta-carotene 3-hydroxylase activity" BROAD [MetaCyc:MONOMER-12386]
synonym: "beta-carotene hydroxylase activity" BROAD []
synonym: "carotene beta-ring hydroxylase activity" BROAD []
xref: EC:1.14.99.-
xref: MetaCyc:RXN-8025
is_a: GO:0004497 ! monooxygenase activity

[Term]
id: GO:0052612
name: adonirubin 3-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: adonirubin + a reduced electron acceptor + oxygen = 3S,3'S-astaxanthin + an oxidized electron acceptor + H2O." [MetaCyc:RXN-8187]
synonym: "beta-carotene hydroxylase activity" BROAD []
synonym: "beta-ring carotenoid 3-hydroxylase activity" BROAD [MetaCyc:MONOMER-12386]
synonym: "carotene beta-ring hydroxylase activity" BROAD []
xref: EC:1.14.99.-
xref: MetaCyc:RXN-8187
is_a: GO:0004497 ! monooxygenase activity

[Term]
id: GO:0052613
name: canthaxanthin 3-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: canthaxanthin + a reduced electron acceptor + oxygen = adonirubin + an oxidized electron acceptor + H2O." [MetaCyc:RXN-8186]
synonym: "beta-carotene hydroxylase activity" BROAD []
synonym: "beta-ring carotenoid 3-hydroxylase activity" BROAD [MetaCyc:MONOMER-12386]
synonym: "carotene beta-ring hydroxylase activity" BROAD []
xref: EC:1.14.99.-
xref: MetaCyc:RXN-8186
is_a: GO:0004497 ! monooxygenase activity

[Term]
id: GO:0052614
name: uracil oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: uracil + NADH + O2 + H+ = ureidoacrylate peracid + NAD+. Ureidoacrylate peracid is spontaneously reduced by NADH to form ureidoacrylate." [MetaCyc:RXN0-6444, PMID:20369853, PMID:20400551]
synonym: "pyrimidine oxygenase activity" BROAD [MetaCyc:RXN0-6444]
xref: MetaCyc:RXN0-6444
is_a: GO:0016491 ! oxidoreductase activity
creation_date: 2010-08-26T10:11:11Z

[Term]
id: GO:0052615
name: ent-kaurene oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + NADPH + ent-kaur-16-ene + oxygen = H2O + NADP+ + ent-kaur-16-en-19-ol." [MetaCyc:1.14.13.78-RXN]
xref: EC:1.14.13.78
xref: MetaCyc:1.14.13.78-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0052616
name: ent-kaur-16-en-19-ol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + NADPH + ent-kaur-16-en-19-ol + oxygen = 2 H2O + NADP+ + ent-kaur-16-en-19-al." [MetaCyc:RXN-5242]
xref: EC:1.14.13.78
xref: MetaCyc:RXN-5242
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0052617
name: ent-kaur-16-en-19-al oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADPH + ent-kaur-16-en-19-al + oxygen = H2O + NADP+ + ent-kaurenoate." [MetaCyc:RXN-7580]
xref: EC:1.14.13.78
xref: MetaCyc:RXN-7580
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0052618
name: coenzyme F420-0:L-glutamate ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP + L-glutamate + factor F420-0 = GDP + H+ + factor gamma-F420-1 + phosphate." [MetaCyc:RXN-8080]
xref: EC:6.3.2.31
xref: MetaCyc:RXN-8080
xref: RHEA:30558
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0052619
name: coenzyme F420-1:gamma-L-glutamate ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP + L-glutamate + factor gamma-F420-1 = GDP + H+ + factor gamma-F420-2 + phosphate." [MetaCyc:RXN-8081]
xref: EC:6.3.2.34
xref: MetaCyc:RXN-8081
xref: RHEA:30526
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0052620
name: thymine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + thymine + acceptor = 5-methyl-barbiturate + donor-H2." [MetaCyc:RXN-8646]
xref: EC:1.17.99.4
xref: MetaCyc:RXN-8646
is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups

[Term]
id: GO:0052621
name: diguanylate cyclase activity
namespace: molecular_function
alt_id: GO:0043789
def: "Catalysis of the reaction: 2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate + 2 H(+)." [EC:2.7.7.65, RHEA:24901]
synonym: "GTP:GTP guanylyltransferase activity" BROAD [EC:2.7.7.65]
xref: EC:2.7.7.65
xref: KEGG:R08057
xref: MetaCyc:RXN0-5359
xref: RHEA:24901
is_a: GO:0016779 ! nucleotidyltransferase activity

[Term]
id: GO:0052622
name: ATP dimethylallyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: delta(2)-isopentenyl diphosphate + ATP = diphosphate + N6-(delta(2)-isopentenyl)adenosine 5'-triphosphate." [EC:2.5.1.27, MetaCyc:RXN-4303]
synonym: "2-isopentenyl-diphosphate:ATP 2-isopentenyltransferase activity" EXACT []
synonym: "2-isopentenyl-diphosphate:ATP delta2-isopentenyltransferase activity" EXACT [KEGG:R08052]
synonym: "ATP isopentenyltransferase activity" EXACT []
synonym: "dimethylallyl-diphosphate:ATP dimethylallyltransferase activity" EXACT [EC:2.5.1.27]
xref: EC:2.5.1.-
xref: KEGG:R08052
xref: MetaCyc:RXN-4303
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups
created_by: gwg
creation_date: 2010-08-26T10:45:38Z

[Term]
id: GO:0052623
name: ADP dimethylallyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: delta2-isopentenyl diphosphate + ADP = diphosphate + N6-(delta(2)-isopentenyl)adenosine 5'-diphosphate." [EC:2.5.1.27, MetaCyc:RXN-4305]
synonym: "2-isopentenyl-diphosphate:ADP 2-isopentenyltransferase activity" EXACT []
synonym: "2-isopentenyl-diphosphate:ADP delta2-isopentenyltransferase activity" EXACT [KEGG:R08051]
synonym: "ADP isopentenyltransferase activity" EXACT []
synonym: "dimethylallyl-diphosphate:ADP dimethylallyltransferase activity" EXACT [EC:2.5.1.27]
xref: EC:2.5.1.-
xref: KEGG:R08051
xref: MetaCyc:RXN-4305
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups
created_by: gwg
creation_date: 2010-08-26T10:45:44Z

[Term]
id: GO:0052624
name: 2-phytyl-1,4-naphthoquinone methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: demethylphylloquinone + S-adenosyl-L-methionine = phylloquinone + S-adenosyl-L-homocysteine + H+." [MetaCyc:RXN-6723, MetaCyc:RXN-7569, PMID:14617060]
synonym: "demethylphylloquinone methyltransferase activity" EXACT []
synonym: "S-adenosyl-L-methionine:2-phytyl-1,4-naphthoquinone methyltransferase activity" EXACT []
synonym: "S-adenosyl-L-methionine:demethylphylloquinone methyltransferase activity" EXACT []
synonym: "S-adenosyl-L-methionine:salicylate carboxyl methyltransferase activity" EXACT []
synonym: "SA methyltransferase activity" BROAD []
synonym: "salicylate methyltransferase activity" BROAD []
synonym: "salicylic acid methyltransferase activity" BROAD []
xref: EC:2.1.1.-
xref: KEGG:R06859
xref: MetaCyc:RXN-6723
xref: MetaCyc:RXN-7569
is_a: GO:0008169 ! C-methyltransferase activity
is_a: GO:0008171 ! O-methyltransferase activity
created_by: gwg
creation_date: 2010-08-26T12:00:06Z

[Term]
id: GO:0052625
name: 4-aminobenzoate amino acid synthetase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-aminobenzoate + ATP + amino acid = 4-aminobenzoyl amino acid conjugate + AMP + diphosphate." [MetaCyc:RXN-10884, PMID:19189963]
synonym: "4-aminobenzoyl amino acid synthetase activity" EXACT []
synonym: "p-aminobenzoate amino acid synthetase activity" EXACT []
synonym: "p-aminobenzoyl amino acid synthetase activity" EXACT []
synonym: "pABA amino acid synthetase activity" EXACT []
xref: EC:6.3.-.-
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0052626
name: benzoate amino acid synthetase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzoate + ATP + amino acid = benzoyl amino acid conjugate + AMP + diphosphate." [MetaCyc:RXN-10886, PMID:19189963]
synonym: "benzoyl amino acid synthetase activity" EXACT []
xref: EC:6.3.-.-
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0052627
name: vanillate amino acid synthetase activity
namespace: molecular_function
def: "Catalysis of the reaction: vanillate + ATP + amino acid = vanillate amino acid conjugate + AMP + diphosphate." [MetaCyc:RXN-10885, PMID:19189963]
xref: EC:6.3.-.-
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0052628
name: 4-hydroxybenzoate amino acid synthetase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxybenzoate + ATP + amino acid = 4-hydroxybenzoyl amino acid conjugate + AMP + diphosphate." [MetaCyc:RXN-10884, PMID:19189963]
synonym: "4-hydroxybenzoyl amino acid synthetase activity" EXACT []
synonym: "4HBA amino acid synthetase activity" EXACT []
synonym: "p-hydroxybenzoate amino acid synthetase activity" EXACT []
synonym: "p-hydroxybenzoyl amino acid synthetase activity" EXACT []
xref: EC:6.3.-.-
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0052629
name: phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = a 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate + 2 H+." [MetaCyc:RXN-10958, PMID:19901554]
xref: EC:3.1.3.-
xref: MetaCyc:RXN-10958
is_a: GO:0034593 ! phosphatidylinositol bisphosphate phosphatase activity

[Term]
id: GO:0052630
name: UDP-N-acetylgalactosamine diphosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: UTP + N-acetyl-alpha-D-galactosamine 1-phosphate = diphosphate + UDP-N-acetyl-D-galactosamine." [EC:2.7.7.23]
subset: gosubset_prok
synonym: "N-acetylgalactosamine 1-phosphate uridylyltransferase" EXACT []
synonym: "N-acetylgalactosamine-1-phosphate uridyltransferase activity" EXACT []
synonym: "UDP-acetylgalactosamine pyrophosphorylase activity" EXACT []
synonym: "UDP-GalNAc pyrophosphorylase activity" EXACT []
synonym: "UDP-N-acetylgalactosamine pyrophosphorylase activity" EXACT []
synonym: "uridine diphosphate-N-acetylgalactosamine pyrophosphorylase activity" EXACT []
synonym: "uridine diphosphoacetylgalactosamine phosphorylase activity" EXACT []
synonym: "uridine diphosphoacetylgalactosamine pyrophosphorylase activity" EXACT []
synonym: "UTP:2-acetamido-2-deoxy-alpha-D-galactose-1-phosphate uridylyltransferase activity" EXACT []
synonym: "UTP:N-acetyl-alpha-D-galactosamine-1-phosphate uridylyltransferase activity" EXACT []
xref: EC:2.7.7.-
is_a: GO:0070569 ! uridylyltransferase activity

[Term]
id: GO:0052631
name: sphingolipid delta-8 desaturase activity
namespace: molecular_function
def: "Catalysis of the formation of a double bond between C8 and C9 of the long chain base of a sphingolipid. For example, sphinganine (d18:0) = 8-sphingenine (d18:1delta8); phytosphinganine (t18:0) = 8-phytosphingenine (t18:1delta8); and 4-sphingenine (18:1delta4) = 4,8-sphingadienine (d18:2delta4,8)." [PMID:17600137, PMID:9786850]
xref: MetaCyc:RXN-7798
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0052633
name: isocitrate hydro-lyase (cis-aconitate-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-aconitate + H2O = isocitrate." [EC:4.2.1.3, GOC:pde, GOC:vw, MetaCyc:ACONITATEHYDR-RXN]
synonym: "aconitate hydratase activity" BROAD [EC:4.2.1.3]
synonym: "cis-aconitase activity" BROAD [EC:4.2.1.3]
synonym: "citrate hydro-lyase activity" BROAD [EC:4.2.1.3]
synonym: "citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" BROAD [EC:4.2.1.3]
synonym: "citrate(isocitrate) hydro-lyase activity" BROAD [EC:4.2.1.3]
xref: KEGG:R01900
xref: MetaCyc:ACONITATEHYDR-RXN
xref: RHEA:22147
is_a: GO:0016836 ! hydro-lyase activity
relationship: has_part GO:0003994 ! aconitate hydratase activity

[Term]
id: GO:0052634
name: C-19 gibberellin 2-beta-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a C-19 gibberellin + 2-oxoglutarate + O2 = a C-19 2-beta-hydroxygibberellin + succinate + CO2. C-19 gibberellin refers to a gibberellin with nineteen carbons." [EC:1.14.11.13, GOC:kad]
synonym: "(C-19 gibberellin-1),2-oxoglutarate:oxygen oxidoreductase (2beta-hydroxylating)" EXACT []
synonym: "C(19) gibberellin 2-oxidase activity" EXACT []
synonym: "C-19 GA 2-oxidase activity" EXACT []
synonym: "C-19 gibberellin 2-beta-hydroxylase activity" EXACT []
synonym: "C-19 gibberellin 2-oxidase activity" EXACT []
synonym: "C-19 gibberellin 2beta-dioxygenase activity" EXACT []
synonym: "C-19 gibberellin 2beta-hydroxylase activity" EXACT []
xref: EC:1.14.11.-
is_a: GO:0045543 ! gibberellin 2-beta-dioxygenase activity

[Term]
id: GO:0052635
name: C-20 gibberellin 2-beta-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a C-20 gibberellin + 2-oxoglutarate + O2 = a C-20 2-beta-hydroxygibberellin + succinate + CO2. C-20 gibberellin refers to a gibberellin with twenty carbons." [EC:1.14.11.13, GOC:kad]
synonym: "(C-20 gibberellin-1),2-oxoglutarate:oxygen oxidoreductase (2beta-hydroxylating)" EXACT []
synonym: "C(20) gibberellin 2-oxidase activity" EXACT []
synonym: "C-20 GA 2-oxidase activity" EXACT []
synonym: "C-20 gibberellin 2-beta-hydroxylase activity" EXACT []
synonym: "C-20 gibberellin 2-oxidase activity" EXACT []
synonym: "C-20 gibberellin 2beta-dioxygenase activity" EXACT []
synonym: "C-20 gibberellin 2beta-hydroxylase activity" EXACT []
xref: EC:1.14.11.-
is_a: GO:0045543 ! gibberellin 2-beta-dioxygenase activity

[Term]
id: GO:0052636
name: arabinosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor)." [GOC:ai]
synonym: "arabinosyl transferase activity" EXACT []
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0052637
name: delta 3-trans-hexadecenoic acid phosphatidylglycerol desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-18:3-3-16:0-phosphatidylglycerol = 1-18:3-3-trans-16:1-phosphatidylglycerol + 2 H+. This reaction is the formation of a trans double bond between carbon 3 and carbon 4 (counting from the carboxyl end) of palmitic acid, which is specifically esterified to the sn-2 glyceryl carbon of phosphatidylglycerol." [GOC:ai, MetaCyc:RXN-8319, PMID:19682287]
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0052638
name: indole-3-butyrate beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: indole-3-butyrate + UDP-D-glucose = indole-3-butyryl-beta-1-D-glucose + UDP." [MetaCyc:RXN-11655]
synonym: "IBA-Glc synthetase activity" EXACT []
synonym: "IBA-glucose synthase activity" EXACT []
synonym: "IBAGlu synthase activity" EXACT []
synonym: "indol-3-ylbutyrylglucose synthase activity" EXACT []
synonym: "indole-3-butyric acid glucosyltransferase activity" EXACT []
synonym: "UDP-glucose:(indol-3-yl)butyrate beta-D-glucosyltransferase activity" EXACT []
synonym: "UDP-glucose:indol-3-ylbutyrate glucosyl-transferase activity" EXACT []
synonym: "UDP-glucose:indol-3-ylbutyrate glucosyltransferase activity" EXACT []
synonym: "UDPG-indol-3-ylbutyryl glucosyl transferase activity" EXACT []
synonym: "UDPglucose:indole-3-butyrate beta-D-glucosyltransferase activity" EXACT []
synonym: "uridine diphosphoglucose-indolebutyrate glucosyltransferase activity" EXACT []
xref: EC:2.4.1.-
xref: MetaCyc:RXN-11655
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0052639
name: salicylic acid glucosyltransferase (ester-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: salicylic acid + UDP-glucose = salicylic acid glucose ester + UDP." [MetaCyc:RXN-11659]
synonym: "salicylic acid glucosyltransferase activity" BROAD [MetaCyc:RXN-11659]
synonym: "UDP:glucose:2-hydroxybenzoic acid glucosyltransferase (ester-forming) activity" EXACT [MetaCyc:RXN-11659]
synonym: "UDP:glucose:SA glucosyltransferase (ester-forming) activity" EXACT [MetaCyc:RXN-11659]
synonym: "UDP:glucose:salicylate glucosyltransferase (ester-forming) activity" EXACT [MetaCyc:RXN-11659]
synonym: "UDP:glucose:salicylic acid glucosyltransferase (ester-forming) activity" EXACT [MetaCyc:RXN-11659]
xref: EC:2.4.1.-
xref: MetaCyc:RXN-11659
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0052640
name: salicylic acid glucosyltransferase (glucoside-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: salicylic acid + UDP-glucose = salicylic acid 2-O-glucoside + UDP." [MetaCyc:RXN-11658]
synonym: "salicylic acid glucosyltransferase activity" BROAD [MetaCyc:RXN-11658]
synonym: "UDP:glucose:2-hydroxybenzoic acid glucosyltransferase (glucoside-forming) activity" EXACT [MetaCyc:RXN-11658]
synonym: "UDP:glucose:SA glucosyltransferase (glucoside-forming) activity" EXACT [MetaCyc:RXN-11658]
synonym: "UDP:glucose:salicylate glucosyltransferase (glucoside-forming) activity" EXACT [MetaCyc:RXN-11658]
synonym: "UDP:glucose:salicylic acid glucosyltransferase (glucoside-forming) activity" EXACT [MetaCyc:RXN-11658]
xref: EC:2.4.1.-
xref: MetaCyc:RXN-11658
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0052641
name: benzoic acid glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzoic acid + UDP-glucose = benzoic acid glucose ester + UDP." [MetaCyc:RXN-11660]
synonym: "benzoate glucosyltransferase activity" EXACT [MetaCyc:RXN-11660]
synonym: "UDP:glucose:BA glucosyltransferase activity" EXACT [MetaCyc:RXN-11660]
synonym: "UDP:glucose:benzoate glucosyltransferase activity" EXACT [MetaCyc:RXN-11660]
synonym: "UDP:glucose:benzoic acid glucosyltransferase activity" EXACT [MetaCyc:RXN-11660]
xref: EC:2.4.1.-
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0052642
name: lysophosphatidic acid phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: lysophosphatidic acid + H2O = phosphate + monoacylglycerol." [PMID:20045079, PMID:7966317]
synonym: "LPA phosphatase activity" EXACT []
synonym: "lysophosphatidate phosphatase activity" EXACT []
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0052643
name: chlorophyllide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving chlorophyllides, any chlorophyll lacking the terpenoid side chain such as phytyl or farnesyl." [CHEBI:38206]
synonym: "chlorophyllide metabolism" EXACT []
is_a: GO:0015994 ! chlorophyll metabolic process

[Term]
id: GO:0052644
name: chlorophyllide a metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving chlorophyllide a, a chlorophyll lacking the terpenoid side chain, which is the functional parent of chlorophyll a." [CHEBI:16900]
synonym: "chlorophyllide a metabolism" EXACT []
is_a: GO:0006082 ! organic acid metabolic process
is_a: GO:0052643 ! chlorophyllide metabolic process

[Term]
id: GO:0052645
name: F420-0 metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving F420-0 (5-O-{[(1S)-1-carboxyethoxy](hydroxy)phosphoryl}-1-deoxy-1-(8-hydroxy-2,4-dioxo-2H-pyrimido[4,5-b]quinolin-10(4H)-yl)-D-ribitol), the fragment of coenzyme F420 remaining after formal hydrolytic removal of all of the glutamate residues." [CHEBI:59532]
synonym: "coenzyme F420-0 metabolic process" EXACT [CHEBI:59532]
synonym: "coenzyme F420-0 metabolism" EXACT [CHEBI:59532]
synonym: "F(420)-0 metabolic process" EXACT [CHEBI:59532]
synonym: "F420-0 metabolism" EXACT []
is_a: GO:0019520 ! aldonic acid metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:0052648 ! ribitol phosphate metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process
created_by: gwg
creation_date: 2010-09-22T04:11:38Z

[Term]
id: GO:0052646
name: alditol phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving alditol phosphates, any phosphorylated polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group." [CHEBI:22297, ISBN:0198506732]
subset: gosubset_prok
synonym: "alditol phosphate metabolism" EXACT []
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process
created_by: gwg
creation_date: 2010-09-22T04:24:21Z

[Term]
id: GO:0052647
name: pentitol phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pentitol phosphates, any phosphorylated alditol with a chain of five carbon atoms in the molecule." [CHEBI:25898, ISBN:0198506732]
subset: gosubset_prok
synonym: "pentitol phosphate metabolism" EXACT []
is_a: GO:0052646 ! alditol phosphate metabolic process
created_by: gwg
creation_date: 2010-09-22T04:26:28Z

[Term]
id: GO:0052648
name: ribitol phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ribitol phosphates, any phosphorylated form of ribitol, the pentitol derived formally by reduction of the -CHO group of either D- or L-ribose." [CHEBI:26554, ISBN:0198506732]
subset: gosubset_prok
synonym: "ribitol phosphate metabolism" EXACT []
is_a: GO:0052647 ! pentitol phosphate metabolic process
created_by: gwg
creation_date: 2010-09-22T04:28:37Z

[Term]
id: GO:0052649
name: coenzyme gamma-F420-2 metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving coenzyme gamma-F420-2 (F420-2; coenzyme F420; N-{N-[O-(7,8-didemethyl-8-hydroxy-5-deazariboflavin phospho)-(S)-lactyl]-gamma-L-glutamyl}-L-glutamate), the amide obtained by formal condensation of the carboxylic acid group of F420-0 with the amino group of L-gamma-glutamyl-L-glutamic acid." [CHEBI:16848]
synonym: "coenzyme F420 metabolic process" EXACT [CHEBI:16848]
synonym: "coenzyme F420 metabolism" EXACT [CHEBI:16848]
synonym: "coenzyme gamma-F420-2 metabolism" EXACT []
synonym: "F420-2 metabolic process" EXACT [CHEBI:16848]
synonym: "F420-2 metabolism" EXACT [CHEBI:16848]
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:0052648 ! ribitol phosphate metabolic process
is_a: GO:0072350 ! tricarboxylic acid metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process
created_by: gwg
creation_date: 2010-09-22T04:32:35Z

[Term]
id: GO:0052650
name: NADP-retinol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: all-trans-retinol + NADP+ = all-trans-retinal + NADPH + H+." [RHEA:25036]
synonym: "all-trans retinal reductase activity" BROAD [EC:1.1.1.300]
synonym: "all-trans-retinol dehydrogenase activity" BROAD [EC:1.1.1.300]
synonym: "NADP(H)-dependent retinol dehydrogenase/reductase activity" EXACT [EC:1.1.1.300]
synonym: "retinol dehydrogenase [NADP+] activity" EXACT [EC:1.1.1.300]
synonym: "retinol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.300]
xref: EC:1.1.1.300
xref: KEGG:R08379
xref: MetaCyc:RXN-10841
xref: RHEA:25036
is_a: GO:0008106 ! alcohol dehydrogenase (NADP+) activity
relationship: part_of GO:0042572 ! retinol metabolic process

[Term]
id: GO:0052651
name: monoacylglycerol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "monoacylglycerol breakdown" EXACT []
synonym: "monoacylglycerol catabolism" EXACT []
synonym: "monoacylglycerol degradation" EXACT []
is_a: GO:0046462 ! monoacylglycerol metabolic process
is_a: GO:0046464 ! acylglycerol catabolic process
creation_date: 2010-09-23T09:26:36Z

[Term]
id: GO:0052652
name: cyclic purine nucleotide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue and the base is a purine." [CHEBI:36982]
synonym: "cyclic purine nucleotide metabolism" EXACT []
is_a: GO:0006164 ! purine nucleotide biosynthetic process
is_a: GO:0009190 ! cyclic nucleotide biosynthetic process
creation_date: 2010-09-23T11:15:59Z

[Term]
id: GO:0052653
name: 3',5'-cyclic diguanylic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 3',5'-cyclic diguanylic acid, a cyclic purine dinucleotide in which the base groups are guanine." [CHEBI:593038]
synonym: "3',5'-cyclic diguanylic acid metabolism" EXACT []
synonym: "cdiGMP metabolic process" EXACT []
synonym: "cdiGMP metabolism" EXACT []
synonym: "cyclic diguanylate metabolic process" EXACT []
synonym: "cyclic diguanylate metabolism" EXACT []
is_a: GO:0009152 ! purine ribonucleotide biosynthetic process
is_a: GO:0052652 ! cyclic purine nucleotide metabolic process
created_by: gwg
creation_date: 2010-09-23T11:16:56Z

[Term]
id: GO:0052654
name: L-leucine transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamatic acid." [EC:2.6.1.42, MetaCyc:BRANCHED-CHAINAMINOTRANSFERLEU-RXN]
subset: goslim_chembl
synonym: "L-leucine aminotransferase activity" EXACT []
xref: EC:2.6.1.42
xref: KEGG:R01090
xref: MetaCyc:BRANCHED-CHAINAMINOTRANSFERLEU-RXN
is_a: GO:0004084 ! branched-chain-amino-acid transaminase activity

[Term]
id: GO:0052655
name: L-valine transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoic acid + L-glutamatic acid." [EC:2.6.1.42, MetaCyc:BRANCHED-CHAINAMINOTRANSFERVAL-RXN]
subset: goslim_chembl
synonym: "L-valine aminotransferase activity" EXACT []
xref: EC:2.6.1.42
xref: KEGG:R01214
xref: MetaCyc:BRANCHED-CHAINAMINOTRANSFERVAL-RXN
is_a: GO:0004084 ! branched-chain-amino-acid transaminase activity

[Term]
id: GO:0052656
name: L-isoleucine transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoic acid + L-glutamic acid." [EC:2.6.1.42, MetaCyc:BRANCHED-CHAINAMINOTRANSFERILEU-RXN]
subset: goslim_chembl
synonym: "L-isoleucine aminotransferase activity" EXACT []
xref: EC:2.6.1.42
xref: KEGG:R02199
xref: MetaCyc:BRANCHED-CHAINAMINOTRANSFERILEU-RXN
is_a: GO:0004084 ! branched-chain-amino-acid transaminase activity

[Term]
id: GO:0052657
name: guanine phosphoribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.8, GOC:curators]
subset: gosubset_prok
synonym: "6-hydroxypurine phosphoribosyltransferase activity" RELATED [EC:2.4.2.8]
synonym: "6-mercaptopurine phosphoribosyltransferase activity" RELATED [EC:2.4.2.8]
synonym: "GMP pyrophosphorylase activity" EXACT [EC:2.4.2.8]
synonym: "GPRT" RELATED [EC:2.4.2.8]
synonym: "guanine-hypoxanthine phosphoribosyltransferase activity" BROAD [EC:2.4.2.8]
synonym: "guanosine 5'-phosphate pyrophosphorylase activity" EXACT [EC:2.4.2.8]
synonym: "guanosine phosphoribosyltransferase activity" EXACT [EC:2.4.2.8]
synonym: "guanylate pyrophosphorylase activity" EXACT [EC:2.4.2.8]
synonym: "guanylic pyrophosphorylase activity" EXACT [EC:2.4.2.8]
synonym: "hypoxanthine-guanine phosphoribosyltransferase activity" BROAD [EC:2.4.2.8]
synonym: "purine-6-thiol phosphoribosyltransferase activity" RELATED [EC:2.4.2.8]
synonym: "Transphosphoribosidase activity" BROAD [EC:2.4.2.8]
xref: EC:2.4.2.8
xref: KEGG:R01229
xref: MetaCyc:GUANPRIBOSYLTRAN-RXN
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0052658
name: inositol-1,4,5-trisphosphate 5-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate." [EC:3.1.3.56, RHEA:19800]
synonym: "1D-myo-inositol-1,4,5-trisphosphate 5-phosphohydrolase activity" EXACT [EC:3.1.3.56]
synonym: "5PTase activity" RELATED [EC:3.1.3.56]
synonym: "D-myo-inositol 1,4,5-triphosphate 5-phosphatase activity" EXACT [EC:3.1.3.56]
synonym: "D-myo-inositol 1,4,5-trisphosphate 5-phosphatase activity" EXACT [EC:3.1.3.56]
synonym: "D-myo-inositol(1,4,5)-trisphosphate 5-phosphatase activity" EXACT [EC:3.1.3.56]
synonym: "inosine triphosphatase activity" RELATED [EC:3.1.3.56]
synonym: "inositol 1,4,5-trisphosphate phosphatase activity" BROAD [EC:3.1.3.56]
synonym: "inositol phosphate 5-phosphomonoesterase activity" BROAD [EC:3.1.3.56]
synonym: "inositol polyphosphate-5-phosphatase activity" BROAD [EC:3.1.3.56]
synonym: "inositol triphosphate 5-phosphomonoesterase activity" BROAD []
synonym: "inositol trisphosphate phosphomonoesterase activity" BROAD [EC:3.1.3.56]
synonym: "Ins(1,4,5)P3 5-phosphatase activity" EXACT [EC:3.1.3.56]
synonym: "InsP(3) 5-phosphatase activity" BROAD [EC:3.1.3.56]
synonym: "InsP3 5-phosphatase activity" BROAD [EC:3.1.3.56]
synonym: "L-myo-inositol 1,4,5-trisphosphate-monoesterase activity" BROAD [EC:3.1.3.56]
synonym: "myo-inositol-1,4,5-trisphosphate 5-phosphatase activity" EXACT [EC:3.1.3.56]
synonym: "type I inositol-polyphosphate phosphatase activity" RELATED [EC:3.1.3.56]
synonym: "type II inositol polyphosphate 5-phosphatase activity" RELATED []
xref: EC:3.1.3.56
xref: KEGG:R03394
xref: MetaCyc:3.1.3.56-RXN
xref: RHEA:19800
is_a: GO:0046030 ! inositol trisphosphate phosphatase activity

[Term]
id: GO:0052659
name: inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate." [EC:3.1.3.56, RHEA:11395]
synonym: "5PTase activity" RELATED [EC:3.1.3.56]
synonym: "D-myo-inositol (1,3,4,5)-polyphosphate 5-phosphatase activity" EXACT [EC:3.1.3.56]
synonym: "inositol polyphosphate-5-phosphatase activity" BROAD [EC:3.1.3.56]
synonym: "Ins(1,3,4,5)P(4) 5-phosphatase activity" EXACT [EC:3.1.3.56]
synonym: "Ins(1,3,4,5)P4 5-phosphatase activity" EXACT [EC:3.1.3.56]
synonym: "type I inositol-polyphosphate phosphatase activity" RELATED [EC:3.1.3.56]
synonym: "type II inositol polyphosphate 5-phosphatase activity" RELATED []
xref: EC:3.1.3.56
xref: KEGG:R03430
xref: MetaCyc:RXN-8730
xref: RHEA:11395
is_a: GO:0052743 ! inositol tetrakisphosphate phosphatase activity

[Term]
id: GO:0052660
name: R-lactaldehyde reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-propane-1,2-diol + NAD+ = (R)-lactaldehyde + NADH + H+." [RHEA:23875]
subset: gosubset_prok
synonym: "(R)-propane-1,2-diol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.77]
synonym: "D-lactaldehyde:propanediol oxidoreductase activity" EXACT [EC:1.1.1.77]
xref: KEGG:R03080
xref: MetaCyc:RXN-8641
xref: RHEA:23875
is_a: GO:0008912 ! lactaldehyde reductase activity

[Term]
id: GO:0052661
name: S-lactaldehyde reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-propane-1,2-diol + NAD+ = (S)-lactaldehyde + NADH + H+." [RHEA:15936]
subset: gosubset_prok
synonym: "(S)-propane-1,2-diol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.77]
synonym: "L-lactaldehyde:propanediol oxidoreductase activity" EXACT [EC:1.1.1.77]
xref: KEGG:R02258
xref: MetaCyc:LACTALDREDUCT-RXN
xref: RHEA:15936
is_a: GO:0008912 ! lactaldehyde reductase activity

[Term]
id: GO:0052662
name: zeaxanthin epoxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: zeaxanthin + NAD(P)H + H+ + O2 = antheraxanthin + NAD(P)+ + H2O." [EC:1.14.13.90]
synonym: "zea-epoxidase activity" EXACT [EC:1.14.13.90]
synonym: "zeaxanthin,NAD(P)H:oxygen oxidoreductase activity" EXACT [EC:1.14.13.90]
xref: EC:1.14.13.90
xref: KEGG:R06946 "zeaxanthin,NADH:oxygen oxidoreductase activity"
xref: KEGG:R07199 "zeaxanthin,NADPH:oxygen oxidoreductase activity"
xref: MetaCyc:RXN-7978
xref: RHEA:24087 "zeaxanthin,NADPH:oxygen oxidoreductase activity"
xref: RHEA:24091 "zeaxanthin,NADH:oxygen oxidoreductase activity"
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0052663
name: antheraxanthin epoxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: antheraxanthin + NAD(P)H + H+ + O2 = all-trans-violaxanthin + NAD(P)+ + H2O." [MetaCyc:RXN-7979]
synonym: "antheraxanthin,NAD(P)H:oxygen oxidoreductase activity" EXACT [EC:1.14.13.90]
xref: EC:1.14.13.90
xref: KEGG:R06947 "antheraxanthin,NADH:oxygen oxidoreductase activity"
xref: KEGG:R07200 "antheraxanthin,NADPH:oxygen oxidoreductase activity"
xref: MetaCyc:RXN-7979
xref: RHEA:14940 "antheraxanthin,NADPH:oxygen oxidoreductase activity"
xref: RHEA:14944 "antheraxanthin,NADH:oxygen oxidoreductase activity"
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0052664
name: nitroalkane oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: nitroalkane + H2O + O2 = an aldehyde or ketone + nitrite + H2O2." [EC:1.7.3.1]
synonym: "NAO activity" EXACT [EC:1.7.3.1]
synonym: "nitroalkane reductase activity" EXACT [EC:1.7.3.1]
synonym: "nitroalkane:oxygen oxidoreductase activity" EXACT [EC:1.7.3.1]
xref: EC:1.7.3.1
xref: KEGG:R00799
xref: MetaCyc:RXN-11045
is_a: GO:0016663 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor
creation_date: 2010-10-11T10:50:59Z

[Term]
id: GO:0052665
name: tRNA (uracil-2'-O-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 2'-O-methyluracil." [EC:2.1.1.34]
subset: gosubset_prok
synonym: "S-adenosyl-L-methionine:tRNA (uracil-2'-O-)-methyltransferase activity" EXACT [EC:2.1.1.34]
synonym: "S-adenosyl-L-methionine:tRNA uracil-2'-O-methyltransferase activity" EXACT [EC:2.1.1.34]
synonym: "transfer ribonucleate uracil 2'-methyltransferase activity" EXACT [EC:2.1.1.34]
synonym: "tRNA (uracil 2')-methyltransferase activity" EXACT [EC:2.1.1.34]
synonym: "tRNA uracil 2'-methyltransferase activity" EXACT [EC:2.1.1.34]
synonym: "tRNA uracil-2'-O-methyltransferase activity" EXACT [EC:2.1.1.34]
xref: EC:2.1.1.-
xref: MetaCyc:RXN0-5143
is_a: GO:0016300 ! tRNA (uracil) methyltransferase activity
created_by: gwg
creation_date: 2010-10-11T01:05:35Z

[Term]
id: GO:0052666
name: tRNA (cytosine-2'-O-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 2'-O-methylcytosine." [EC:2.1.1.34]
subset: gosubset_prok
synonym: "S-adenosyl-L-methionine:tRNA (cytosine-2'-O-)-methyltransferase activity" EXACT [EC:2.1.1.34]
synonym: "S-adenosyl-L-methionine:tRNA cytosine-2'-O-methyltransferase activity" EXACT [EC:2.1.1.34]
synonym: "transfer ribonucleate cytosine 2'-methyltransferase activity" EXACT [EC:2.1.1.34]
synonym: "tRNA (cytosine 2')-methyltransferase activity" EXACT [EC:2.1.1.34]
synonym: "tRNA cytosine 2'-methyltransferase activity" EXACT [EC:2.1.1.34]
synonym: "tRNA cytosine-2'-O-methyltransferase activity" EXACT [EC:2.1.1.34]
xref: EC:2.1.1.-
xref: MetaCyc:RXN0-5143
is_a: GO:0016427 ! tRNA (cytosine) methyltransferase activity
created_by: gwg
creation_date: 2010-10-11T01:05:47Z

[Term]
id: GO:0052667
name: phosphomethylethanolamine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-methylethanolamine phosphate + S-adenosyl-L-methionine = N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine + H(+)." [KEGG:R06868, MetaCyc:RXN-5642, RHEA:25322]
synonym: "N-methylethanolamine phosphate N-methyltransferase activity" EXACT []
synonym: "S-adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase activity" EXACT systematic_synonym [KEGG:R06868]
xref: EC:2.1.1.-
xref: KEGG:R06868
xref: MetaCyc:RXN-5642
xref: RHEA:25322
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
created_by: gwg
creation_date: 2011-04-11T11:36:47Z

[Term]
id: GO:0052668
name: farnesol kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: farnesol + nucleoside triphosphate = farnesyl monophosphate + nucleoside diphosphate." [GOC:kd, MetaCyc:RXN-11625]
synonym: "farnesol phosphotransferase activity" EXACT []
synonym: "trans,trans-farnesol kinase activity" NARROW []
xref: EC:2.7.1.-
is_a: GO:0052673 ! prenol kinase activity
created_by: gwg
creation_date: 2011-04-11T01:19:25Z

[Term]
id: GO:0052669
name: CTP:2-trans,-6-trans-farnesol kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,-6-trans-farnesol + CTP = 2-trans,-6-trans-farnesyl monophosphate + CDP + H+." [MetaCyc:RXN-11625]
synonym: "CTP:2-trans,-6-trans-farnesol phosphotransferase activity" EXACT []
xref: EC:2.7.1.-
xref: MetaCyc:RXN-11625
is_a: GO:0052668 ! farnesol kinase activity
created_by: gwg
creation_date: 2011-04-11T01:32:05Z

[Term]
id: GO:0052670
name: geraniol kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: geraniol + nucleoside triphosphate = geranyl monophosphate + nucleoside diphosphate." [GOC:kd]
synonym: "geraniol phosphotransferase activity" EXACT []
xref: EC:2.7.1.-
is_a: GO:0052673 ! prenol kinase activity
created_by: gwg
creation_date: 2011-04-11T03:14:02Z

[Term]
id: GO:0052671
name: geranylgeraniol kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranylgeraniol + nucleoside triphosphate = all-trans-geranyl-geranyl monophosphate + nucleoside diphosphate." [GOC:kd, MetaCyc:RXN-11629]
synonym: "geranylgeraniol phosphotransferase activity" EXACT []
xref: EC:2.7.1.-
is_a: GO:0052673 ! prenol kinase activity
created_by: gwg
creation_date: 2011-04-11T03:18:44Z

[Term]
id: GO:0052672
name: CTP:geranylgeraniol kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranylgeraniol + CTP = all-trans-geranyl-geranyl monophosphate + CDP." [MetaCyc:RXN-11629]
synonym: "CTP:geranylgeraniol phosphotransferase activity" EXACT []
xref: EC:2.7.1.-
xref: MetaCyc:RXN-11629
is_a: GO:0052671 ! geranylgeraniol kinase activity
created_by: gwg
creation_date: 2011-04-11T03:26:04Z

[Term]
id: GO:0052673
name: prenol kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: prenol + nucleoside triphosphate = prenyl phosphate + nucleoside diphosphate activity." [GOC:ai, GOC:kd]
synonym: "prenol phosphotransferase activity" EXACT []
synonym: "prenyl alcohol kinase activity" EXACT []
synonym: "prenyl alcohol phosphotransferase activity" EXACT []
xref: EC:2.7.1.-
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
created_by: gwg
creation_date: 2011-04-11T04:02:23Z

[Term]
id: GO:0052674
name: ent-pimara-9(11),15-diene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ent-copalyl diphosphate = ent-pimara-9(11),15-diene + diphosphate." [RHEA:25547]
synonym: "ent-copalyl-diphosphate diphosphate-lyase [ent-pimara-9(11),15-diene-forming] activity" EXACT systematic_synonym [EC:4.2.3.31]
synonym: "PMD synthase activity" BROAD [EC:4.2.3.31]
xref: EC:4.2.3.31
xref: MetaCyc:RXN-9299
xref: RHEA:25547
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0052675
name: 3-methylbutanol:NADP oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-methylbutanol + NADP+ = 3-methylbutanal + NADPH + H+. 3-methylbutanal is also known as isovaleraldehyde." [EC:1.1.1.265, KEGG:R05686]
synonym: "3-methylbutanal reductase (NADP) activity" EXACT []
synonym: "3-methylbutanol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.265]
synonym: "3-methylbutyraldehyde reductase (NADP) activity" EXACT []
synonym: "isoamyl alcohol oxidase (NADP) activity" EXACT []
xref: KEGG:R05686
xref: RHEA:18528
is_a: GO:0008106 ! alcohol dehydrogenase (NADP+) activity
created_by: gwg
creation_date: 2011-04-12T11:19:27Z

[Term]
id: GO:0052676
name: 3-methylbutanol:NAD oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-methylbutanol + NAD+ = 3-methylbutanal + NADH + H+. 3-methylbutanal is also known as isovaleraldehyde." [EC:1.1.1.265, KEGG:R05685]
synonym: "3-methylbutanal reductase (NAD) activity" EXACT []
synonym: "3-methylbutanol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.265]
synonym: "3-methylbutyraldehyde reductase (NAD) activity" EXACT []
synonym: "isoamyl alcohol oxidase (NAD) activity" EXACT []
xref: KEGG:R05685
xref: RHEA:18532
is_a: GO:0004022 ! alcohol dehydrogenase (NAD) activity
created_by: gwg
creation_date: 2011-04-12T11:22:42Z

[Term]
id: GO:0052677
name: D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-arabinitol + NADP+ = D-xylulose + NADPH + H+." [EC:1.1.1.287]
synonym: "ARD1p" RELATED [EC:1.1.1.287]
synonym: "D-arabinitol dehydrogenase 1 activity" BROAD [EC:1.1.1.287]
synonym: "D-arabinitol:NADP+ dehydrogenase activity" BROAD [EC:1.1.1.287]
synonym: "NADP+-dependent D-arabinitol dehydrogenase activity" BROAD [EC:1.1.1.287]
xref: EC:1.1.1.-
xref: KEGG:R07143
xref: MetaCyc:RXN-7971
xref: RHEA:21279
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
created_by: gwg
creation_date: 2011-04-12T02:33:43Z

[Term]
id: GO:0052678
name: levopimaradiene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (+)-copalyl diphosphate = abieta-8(14),12-diene + diphosphate." [RHEA:25551]
synonym: "ent-copalyl-diphosphate diphosphate-lyase [ent-abieta-8(14),12-diene-forming] activity" EXACT systematic_synonym [EC:4.2.3.32]
xref: EC:4.2.3.32
xref: KEGG:R06302
xref: MetaCyc:4.2.3.32-RXN
xref: RHEA:25551
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0052679
name: terpentetriene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: terpentedienyl diphosphate = diphosphate + terpentetriene." [RHEA:25620]
synonym: "terpentedienyl-diphosphate diphosphate-lyase (terpentetriene-forming) activity" EXACT systematic_synonym [EC:4.2.3.36]
xref: EC:4.2.3.36
xref: MetaCyc:RXN-9455
xref: RHEA:25620
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0052680
name: epi-isozizaene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (+)-epi-isozizaene + diphosphate." [RHEA:25995]
synonym: "(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(+)-epi-isozizaene-forming] activity" EXACT systematic_synonym [EC:4.2.3.37, KEGG:R07830]
xref: EC:4.2.3.37
xref: KEGG:R07830
xref: MetaCyc:RXN-9349
xref: RHEA:25995
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0052681
name: alpha-bisabolene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (E,R)-alpha-bisabolene + diphosphate." [RHEA:25439]
synonym: "(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(E)-alpha-bisabolene-forming] activity" EXACT systematic_synonym [EC:4.2.3.38]
synonym: "bisabolene synthase activity" BROAD [KEGG:R08370]
xref: EC:4.2.3.38
xref: KEGG:R08370
xref: MetaCyc:RXN-8550
xref: RHEA:25439
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0052682
name: epi-cedrol synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + H2O = epi-cedrol + diphosphate." [RHEA:26118]
synonym: "(2E,6E)-farnesyl-diphosphate diphosphate-lyase (8-epi-cedrol-forming) activity" EXACT systematic_synonym [EC:4.2.3.39]
synonym: "8-epicedrol synthase activity" EXACT []
synonym: "epicedrol synthase activity" EXACT []
xref: EC:4.2.3.39
xref: KEGG:R09140
xref: MetaCyc:RXN-10004
xref: RHEA:26118
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0052683
name: (Z)-gamma-bisabolene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (Z)-gamma-bisabolene + diphosphate." [RHEA:26084]
synonym: "(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(Z)-gamma-bisabolene-forming] activity" EXACT systematic_synonym [EC:4.2.3.40]
xref: EC:4.2.3.40
xref: MetaCyc:RXN-10005
xref: RHEA:26084
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0052684
name: L-serine hydro-lyase (adding indole, L-tryptophan-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: indole + L-serine = L-tryptophan + H2O." [MetaCyc:RXN0-2382]
synonym: "L-serine hydro-lyase (adding indole; L-tryptophan-forming) activity" EXACT [GOC:bf]
synonym: "tryptophan synthase beta subunit activity" NARROW []
xref: EC:4.2.1.-
xref: KEGG:R00674
xref: MetaCyc:RXN0-2382
xref: RHEA:26435
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0052685
name: perillic acid:CoA ligase (ADP-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: perillic acid + CoA-SH + ATP = H2O + ADP + phosphate + perillyl-CoA." [KEGG:R06368]
synonym: "perillyl-CoA synthetase activity" BROAD [UM-BBD_reactionID:r0731]
xref: EC:6.2.1.-
xref: KEGG:R06367
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0052686
name: perillic acid:CoA ligase (AMP-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: perillic acid + CoA-SH + ATP = H2O + AMP + diphosphate + perillyl-CoA." [KEGG:R06368]
synonym: "perillyl-CoA synthetase activity" BROAD [UM-BBD_reactionID:r0731]
xref: EC:6.2.1.-
xref: KEGG:R06368
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0052687
name: (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: (3R)-3-isopropenyl-6-oxoheptanoate + CoA-SH + ATP = H2O + ADP + phosphate + (3R)-3-isopropenyl-6-oxoheptanoyl-CoA." [KEGG:R06396]
synonym: "3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity" BROAD [UM-BBD_reactionID:r0737]
xref: EC:6.2.1.-
xref: KEGG:R06396
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0052688
name: (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: (3R)-3-isopropenyl-6-oxoheptanoate + CoA-SH + ATP = H2O + AMP + diphosphate + (3R)-3-isopropenyl-6-oxoheptanoyl-CoA." [KEGG:R06515]
synonym: "3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity" BROAD [UM-BBD_reactionID:r0737]
xref: EC:6.2.1.-
xref: KEGG:R06515
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0052689
name: carboxylic ester hydrolase activity
namespace: molecular_function
alt_id: GO:0004091
alt_id: GO:0004302
alt_id: GO:0004759
alt_id: GO:0016789
def: "Catalysis of the hydrolysis of a carboxylic ester bond." [EC:3.1.1, EC:3.1.1.1, GOC:curators]
subset: gosubset_prok
synonym: "Ali-esterase activity" RELATED [EC:3.1.1.1]
synonym: "ali-esterase activity" NARROW [EC:3.1.1.1]
synonym: "alpha-carboxylesterase activity" NARROW [EC:3.1.1.1]
synonym: "B-esterase activity" RELATED [EC:3.1.1.1]
synonym: "carboxyesterase activity" EXACT [EC:3.1.1.1]
synonym: "carboxyl ester hydrolase activity" EXACT [EC:3.1.1.1]
synonym: "carboxylate esterase activity" EXACT [EC:3.1.1.1]
synonym: "carboxylesterase activity" EXACT []
synonym: "carboxylic acid esterase activity" EXACT []
synonym: "carboxylic ester hydrolase activity" RELATED []
synonym: "carboxylic esterase activity" EXACT [EC:3.1.1.1]
synonym: "cocaine esterase activity" NARROW [EC:3.1.1.1]
synonym: "esterase A" RELATED [EC:3.1.1.1]
synonym: "esterase B" RELATED [EC:3.1.1.1]
synonym: "nonspecific carboxylesterase activity" RELATED [EC:3.1.1.1]
synonym: "procaine esterase activity" NARROW [EC:3.1.1.1]
synonym: "serine esterase activity" RELATED []
synonym: "triacetin esterase" NARROW [EC:3.1.1.1]
synonym: "vitamin A esterase" NARROW [EC:3.1.1.1]
xref: EC:3.1.1
xref: EC:3.1.1.1
xref: KEGG:R00630
xref: MetaCyc:CARBOXYLESTERASE-RXN
xref: UM-BBD_reactionID:r1025
is_a: GO:0016788 ! hydrolase activity, acting on ester bonds

[Term]
id: GO:0052690
name: trichloro-p-hydroquinone reductive dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3,6-trichlorohydroquinone + 2 glutathione = 2,6-dichlorohydroquinone + glutathione disulfide + HCl." [UM-BBD_reactionID:r0031, UM-BBD_reactionID:r0315]
synonym: "pentaerythritol tetranitrate reductase activity" RELATED [UM-BBD_enzymeID:e0028]
synonym: "tetrachlorohydroquinone reductive dehalogenase activity" RELATED [UM-BBD_enzymeID:e0251]
synonym: "trichlorohydroquinone reductive dehalogenase activity" EXACT []
synonym: "xenobiotic reductase activity" BROAD [UM-BBD_enzymeID:e0028]
xref: EC:1.6.99.1
xref: EC:1.8.99.-
xref: UM-BBD_reactionID:r0031
xref: UM-BBD_reactionID:r0315
is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors
is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors

[Term]
id: GO:0052691
name: UDP-arabinopyranose mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-beta-L-arabinofuranose = UDP-beta-L-arabinopyranose." [EC:5.4.99.30, RHEA:28353]
synonym: "UDP-arabinopyranose pyranomutase activity" EXACT systematic_synonym [EC:5.4.99.30]
synonym: "UDP-L-Ara mutase activity" EXACT [EC:5.4.99.30]
synonym: "UDP-L-arabinopyranose furanomutase activity" EXACT [EC:5.4.99.30]
synonym: "UDP-L-arabinose mutase activity" EXACT [EC:5.4.99.30]
synonym: "uridine-diphosphate-L-arabinose mutase activity" EXACT [EC:5.4.99.30]
xref: EC:5.4.99.30
xref: MetaCyc:RXN-11552
xref: RHEA:28353
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0052692
name: raffinose alpha-galactosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: raffinose + H2O = alpha-D-galactose + sucrose." [MetaCyc:RXN-11502]
synonym: "alkaline alpha-galactosidase activity" BROAD []
synonym: "raffinose galactohydrolase activity" BROAD []
synonym: "raffinose-specific alkaline alpha-galactosidase activity" EXACT [PMID:20739305]
xref: EC:3.2.1.22
xref: KEGG:R01103
xref: MetaCyc:RXN-11502
is_a: GO:0004557 ! alpha-galactosidase activity

[Term]
id: GO:0052693
name: epoxyqueuosine reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: epoxyqueuosine in tRNA + reductant = queuosine in tRNA + oxidised reductant." [PMID:21502530]
xref: EC:1.-.-.-
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0052694
name: jasmonoyl-isoleucine-12-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: jasmonoyl-isoleucine + NADPH + H+ + O2 = 12-hydroxy-jasmonoyl-isoleucine + NADP+ + H2O." [MetaCyc:RXN-12421, PMID:21576464]
xref: MetaCyc:RXN-12421
is_a: GO:0004497 ! monooxygenase activity

[Term]
id: GO:0052695
name: cellular glucuronidation
namespace: biological_process
def: "The modification of an organic chemical by the conjugation of glucuronic acid. The substances resulting from glucuronidation are known as glucuronosides (or glucuronides) and are often much more water-soluble than the non-glucuronic acid-containing precursor." [GOC:BHF]
synonym: "cellular glucuronide biosynthesis" EXACT []
synonym: "cellular glucuronide biosynthetic process" EXACT []
synonym: "cellular glucuronoside biosynthesis" EXACT []
synonym: "cellular glucuronoside biosynthetic process" EXACT []
is_a: GO:0019585 ! glucuronate metabolic process
creation_date: 2011-07-27T05:28:18Z

[Term]
id: GO:0052696
name: flavonoid glucuronidation
namespace: biological_process
def: "The modification of a flavonoid by the conjugation of glucuronic acid. The resultant flavonoid glucuronosides are often much more water-soluble than the precursor." [GOC:BHF, PMID:20056724]
synonym: "flavonoid glucuronide biosynthesis" EXACT []
synonym: "flavonoid glucuronide biosynthetic process" EXACT []
synonym: "flavonoid glucuronoside biosynthesis" EXACT []
synonym: "flavonoid glucuronoside biosynthetic process" EXACT []
is_a: GO:0009812 ! flavonoid metabolic process
is_a: GO:0052695 ! cellular glucuronidation
created_by: gwg
creation_date: 2011-07-27T05:37:44Z

[Term]
id: GO:0052697
name: xenobiotic glucuronidation
namespace: biological_process
def: "The modification of a xenobiotic substance by the conjugation of glucuronic acid. The resultant glucuronosides are often much more water-soluble than the xenobiotic precursor, enabling efficient excretion." [GOC:BHF, PMID:20056724]
synonym: "phase II metabolism" NARROW []
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0052695 ! cellular glucuronidation
created_by: gwg
creation_date: 2011-07-27T05:37:50Z

[Term]
id: GO:0052698
name: ergothioneine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ergothioneine, a naturally occurring metabolite of histidine with antioxidant properties." [CHEBI:4828, Wikipedia:Ergothioneine]
synonym: "(2S)-3-(2-mercapto-1H-imidazol-5-yl)-2-(trimethylazaniumyl)propanoate metabolic process" EXACT [CHEBI:4828]
synonym: "2-mercaptoergothioneine trimethylbetaine metabolic process" EXACT [CHEBI:4828]
synonym: "2-mercaptoergothioneine trimethylbetaine metabolism" EXACT [CHEBI:4828]
synonym: "ergothioneine metabolism" EXACT []
is_a: GO:0006577 ! amino-acid betaine metabolic process
is_a: GO:0052701 ! cellular modified histidine metabolic process
created_by: gwg
creation_date: 2011-08-01T03:52:11Z

[Term]
id: GO:0052699
name: ergothioneine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ergothioneine, a naturally occurring metabolite of histidine with antioxidant properties." [CHEBI:4828, Wikipedia:Ergothioneine]
synonym: "(2S)-3-(2-mercapto-1H-imidazol-5-yl)-2-(trimethylazaniumyl)propanoate biosynthetic process" EXACT [CHEBI:4828]
synonym: "2-mercaptoergothioneine trimethylbetaine anabolism" EXACT [GOC:curators]
synonym: "2-mercaptoergothioneine trimethylbetaine biosynthesis" EXACT [GOC:curators]
synonym: "2-mercaptoergothioneine trimethylbetaine biosynthetic process" EXACT [CHEBI:4828]
synonym: "2-mercaptoergothioneine trimethylbetaine formation" EXACT [GOC:curators]
synonym: "2-mercaptoergothioneine trimethylbetaine synthesis" EXACT [GOC:curators]
synonym: "ergothioneine anabolism" EXACT [GOC:curators]
synonym: "ergothioneine biosynthesis" EXACT [GOC:curators]
synonym: "ergothioneine formation" EXACT [GOC:curators]
synonym: "ergothioneine synthesis" EXACT [GOC:curators]
is_a: GO:0006578 ! amino-acid betaine biosynthetic process
is_a: GO:0052698 ! ergothioneine metabolic process
is_a: GO:0052703 ! cellular modified histidine biosynthetic process
created_by: gwg
creation_date: 2011-08-01T03:56:19Z

[Term]
id: GO:0052700
name: ergothioneine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ergothioneine, a naturally occurring metabolite of histidine with antioxidant properties." [CHEBI:4828, Wikipedia:Ergothioneine]
synonym: "(2S)-3-(2-mercapto-1H-imidazol-5-yl)-2-(trimethylazaniumyl)propanoate catabolic process" EXACT [CHEBI:4828]
synonym: "2-mercaptoergothioneine trimethylbetaine breakdown" EXACT [GOC:curators]
synonym: "2-mercaptoergothioneine trimethylbetaine catabolic process" EXACT [CHEBI:4828]
synonym: "2-mercaptoergothioneine trimethylbetaine catabolism" EXACT [GOC:curators]
synonym: "2-mercaptoergothioneine trimethylbetaine degradation" EXACT [GOC:curators]
synonym: "ergothioneine breakdown" EXACT [GOC:curators]
synonym: "ergothioneine catabolism" EXACT [GOC:curators]
synonym: "ergothioneine degradation" EXACT [GOC:curators]
is_a: GO:0006579 ! amino-acid betaine catabolic process
is_a: GO:0052698 ! ergothioneine metabolic process
is_a: GO:0052702 ! cellular modified histidine catabolic process
created_by: gwg
creation_date: 2011-08-01T03:56:22Z

[Term]
id: GO:0052701
name: cellular modified histidine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving compounds derived from histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [CHEBI:24599, GOC:ai]
synonym: "cellular histidine derivative metabolic process" EXACT [GOC:curators]
synonym: "cellular histidine derivative metabolism" EXACT []
synonym: "cellular modified histidine metabolism" EXACT [GOC:curators]
synonym: "histidine derivative metabolic process" EXACT [GOC:curators]
synonym: "modified histidine metabolic process" EXACT [GOC:curators]
synonym: "modified histidine metabolism" EXACT [GOC:curators]
is_a: GO:0006575 ! cellular modified amino acid metabolic process
is_a: GO:0052803 ! imidazole-containing compound metabolic process
is_a: GO:1901605 ! alpha-amino acid metabolic process
creation_date: 2011-08-01T03:47:00Z

[Term]
id: GO:0052702
name: cellular modified histidine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of compounds derived from histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:ai]
subset: gosubset_prok
synonym: "cellular histidine derivative breakdown" EXACT []
synonym: "cellular histidine derivative catabolic process" EXACT [GOC:curators]
synonym: "cellular histidine derivative catabolism" EXACT []
synonym: "cellular histidine derivative degradation" EXACT []
synonym: "cellular modified histidine breakdown" EXACT [GOC:curators]
synonym: "cellular modified histidine catabolism" EXACT [GOC:curators]
synonym: "cellular modified histidine degradation" EXACT [GOC:curators]
synonym: "histidine derivative catabolic process" EXACT [GOC:curators]
synonym: "modified histidine catabolic process" EXACT [GOC:curators]
synonym: "modified histidine catabolism" EXACT [GOC:curators]
is_a: GO:0042219 ! cellular modified amino acid catabolic process
is_a: GO:0052701 ! cellular modified histidine metabolic process
is_a: GO:0052805 ! imidazole-containing compound catabolic process
is_a: GO:1901606 ! alpha-amino acid catabolic process
created_by: gwg
creation_date: 2011-08-01T03:48:41Z

[Term]
id: GO:0052703
name: cellular modified histidine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of compounds derived from histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [CHEBI:24599, GOC:ai]
subset: gosubset_prok
synonym: "cellular histidine derivative anabolism" EXACT []
synonym: "cellular histidine derivative biosynthesis" EXACT []
synonym: "cellular histidine derivative biosynthetic process" EXACT [GOC:curators]
synonym: "cellular histidine derivative formation" EXACT []
synonym: "cellular histidine derivative synthesis" EXACT []
synonym: "cellular modified histidine anabolism" EXACT [GOC:curators]
synonym: "cellular modified histidine biosynthesis" EXACT [GOC:curators]
synonym: "cellular modified histidine formation" EXACT [GOC:curators]
synonym: "cellular modified histidine synthesis" EXACT [GOC:curators]
synonym: "histidine derivative biosynthetic process" EXACT [GOC:curators]
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0042398 ! cellular modified amino acid biosynthetic process
is_a: GO:0052701 ! cellular modified histidine metabolic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901607 ! alpha-amino acid biosynthetic process
created_by: gwg
creation_date: 2011-08-01T03:49:39Z

[Term]
id: GO:0052704
name: ergothioneine biosynthesis from histidine via N-alpha,N-alpha,N-alpha-trimethyl-L-histidine
namespace: biological_process
def: "The pathway resulting in the formation of ergothioneine from histidine. Histidine undergoes three methylations by a histidine-alpha-N-methyltransferase (EC:2.1.1.44) to form N-alpha,N-alpha,N-alpha-trimethyl-L-histidine (also known as hercynine or histidine betaine). N-alpha,N-alpha,N-alpha-trimethyl-L-histidine is modified by the ligation of gamma-glutamyl-cysteine and oxygen; this intermediate undergoes further modification by the removal of glutamate to produce hercynylcysteine sulfoxide. Finally, a beta-lyase acts on this compound, removing pyruvate, ammonia and oxygen to produce ergothioneine." [DOI:10.1021/ja101721e, EC:2.1.1.44, PMID:4276459, PMID:5484456, Wikipedia:Ergothioneine]
is_a: GO:0006548 ! histidine catabolic process
is_a: GO:0052699 ! ergothioneine biosynthetic process
is_a: GO:0052708 ! N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process
relationship: has_part GO:0052707 ! N-alpha,N-alpha,N-alpha-trimethyl-L-histidine biosynthesis from histidine
relationship: has_part GO:0052711 ! ergothioneine biosynthesis from N-alpha,N-alpha,N-alpha-trimethyl-L-histidine
creation_date: 2011-08-05T11:31:52Z

[Term]
id: GO:0052705
name: methylhistidine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + N-alpha-methyl-L-histidine = S-adenosyl-L-homocysteine + N-alpha,N-alpha-dimethyl-L-histidine." [EC:2.1.1.44]
synonym: "histidine-alpha-N-methyltransferase activity" BROAD [EC:2.1.1.44]
synonym: "methylhistidine methyltransferase activity" EXACT [EC:2.1.1.44]
synonym: "S-adenosyl-L-methionine:alpha-N-dimethyl-L-histidine alpha-N-methyltransferase activity" EXACT [EC:2.1.1.44]
synonym: "S-adenosyl-L-methionine:N-alpha-dimethyl-L-histidine N-alpha-methyltransferase activity" EXACT [EC:2.1.1.44]
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
created_by: gwg
creation_date: 2011-08-05T11:54:54Z

[Term]
id: GO:0052706
name: histidine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + L-histidine = S-adenosyl-L-homocysteine + N-alpha,N-alpha,N-alpha-trimethyl-L-histidine." [EC:2.1.1.44]
synonym: "histidine methyltransferase activity" EXACT [EC:2.1.1.44]
synonym: "histidine-alpha-N-methyltransferase activity" BROAD [EC:2.1.1.44]
synonym: "S-adenosyl-L-methionine:L-histidine alpha-N-methyltransferase activity" EXACT [EC:2.1.1.44]
synonym: "S-adenosyl-L-methionine:L-histidine Nalpha-methyltransferase activity" EXACT [EC:2.1.1.44]
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
created_by: gwg
creation_date: 2011-08-05T11:57:40Z

[Term]
id: GO:0052707
name: N-alpha,N-alpha,N-alpha-trimethyl-L-histidine biosynthesis from histidine
namespace: biological_process
def: "The pathway resulting in the formation of N-alpha,N-alpha,N-alpha-trimethyl-L-histidine from histidine. Histidine undergoes three methylations by a histidine-alpha-N-methyltransferase (EC:2.1.1.44) to form N-alpha,N-alpha,N-alpha-trimethyl-L-histidine (also known as hercynine or histidine betaine)." [EC:2.1.1.44]
synonym: "hercynine biosynthesis from histidine" EXACT []
synonym: "histidine betaine biosynthesis from histidine" EXACT []
synonym: "histidine catabolic process to hercynine" EXACT []
synonym: "histidine catabolism to hercynine" EXACT []
synonym: "histidine catabolism to N-alpha,N-alpha,N-alpha-trimethyl-L-histidine" EXACT []
xref: KEGG:R01169
is_a: GO:0006548 ! histidine catabolic process
is_a: GO:0052709 ! N-alpha,N-alpha,N-alpha-trimethyl-L-histidine biosynthetic process
relationship: has_part GO:0030745 ! dimethylhistidine N-methyltransferase activity
relationship: has_part GO:0052705 ! methylhistidine N-methyltransferase activity
relationship: has_part GO:0052706 ! histidine N-methyltransferase activity
created_by: gwg
creation_date: 2011-08-05T02:07:24Z

[Term]
id: GO:0052708
name: N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving N-alpha,N-alpha,N-alpha-trimethyl-L-histidine, also known as histidine betaine or hercynine, a trimethylated derivative of histidine." [CHEBI:15781, KEGG:C05575]
synonym: "hercynine metabolic process" EXACT [CHEBI:15781]
synonym: "hercynine metabolism" EXACT [CHEBI:15781]
synonym: "histidine betaine metabolic process" EXACT [CHEBI:15781]
synonym: "histidine betaine metabolism" EXACT [CHEBI:15781]
synonym: "N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolism" EXACT []
is_a: GO:0052701 ! cellular modified histidine metabolic process
is_a: GO:0097164 ! ammonium ion metabolic process
created_by: gwg
creation_date: 2011-08-05T02:13:31Z

[Term]
id: GO:0052709
name: N-alpha,N-alpha,N-alpha-trimethyl-L-histidine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of N-alpha,N-alpha,N-alpha-trimethyl-L-histidine, also known as histidine betaine or hercynine, a trimethylated derivative of histidine." [CHEBI:15781, KEGG:C05575]
synonym: "hercynine anabolism" EXACT [GOC:curators]
synonym: "hercynine biosynthesis" EXACT [GOC:curators]
synonym: "hercynine biosynthetic process" EXACT [GOC:curators]
synonym: "hercynine formation" EXACT [GOC:curators]
synonym: "hercynine synthesis" EXACT [GOC:curators]
synonym: "histidine betaine anabolism" EXACT [GOC:curators]
synonym: "histidine betaine biosynthesis" EXACT [GOC:curators]
synonym: "histidine betaine biosynthetic process" EXACT [GOC:curators]
synonym: "histidine betaine formation" EXACT [GOC:curators]
synonym: "histidine betaine synthesis" EXACT [GOC:curators]
synonym: "N-alpha,N-alpha,N-alpha-trimethyl-L-histidine anabolism" EXACT [GOC:curators]
synonym: "N-alpha,N-alpha,N-alpha-trimethyl-L-histidine biosynthesis" EXACT [GOC:curators]
synonym: "N-alpha,N-alpha,N-alpha-trimethyl-L-histidine formation" EXACT [GOC:curators]
synonym: "N-alpha,N-alpha,N-alpha-trimethyl-L-histidine synthesis" EXACT [GOC:curators]
is_a: GO:0052703 ! cellular modified histidine biosynthetic process
is_a: GO:0052708 ! N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process
created_by: gwg
creation_date: 2011-08-05T02:22:05Z

[Term]
id: GO:0052710
name: N-alpha,N-alpha,N-alpha-trimethyl-L-histidine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of N-alpha,N-alpha,N-alpha-trimethyl-L-histidine, also known as histidine betaine or hercynine, a trimethylated derivative of histidine." [CHEBI:15781, KEGG:C05575]
synonym: "hercynine breakdown" EXACT [GOC:curators]
synonym: "hercynine catabolic process" EXACT [GOC:curators]
synonym: "hercynine catabolism" EXACT [GOC:curators]
synonym: "hercynine degradation" EXACT [GOC:curators]
synonym: "histidine betaine breakdown" EXACT [GOC:curators]
synonym: "histidine betaine catabolic process" EXACT [GOC:curators]
synonym: "histidine betaine catabolism" EXACT [GOC:curators]
synonym: "histidine betaine degradation" EXACT [GOC:curators]
synonym: "N-alpha,N-alpha,N-alpha-trimethyl-L-histidine breakdown" EXACT [GOC:curators]
synonym: "N-alpha,N-alpha,N-alpha-trimethyl-L-histidine catabolism" EXACT [GOC:curators]
synonym: "N-alpha,N-alpha,N-alpha-trimethyl-L-histidine degradation" EXACT [GOC:curators]
is_a: GO:0052702 ! cellular modified histidine catabolic process
is_a: GO:0052708 ! N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process
created_by: gwg
creation_date: 2011-08-05T02:22:54Z

[Term]
id: GO:0052711
name: ergothioneine biosynthesis from N-alpha,N-alpha,N-alpha-trimethyl-L-histidine
namespace: biological_process
def: "The pathway resulting in the formation of ergothioneine from N-alpha,N-alpha,N-alpha-trimethyl-L-histidine (also known as hercynine or histidine betaine)." [KEGG:R04878]
synonym: "ergothioneine biosynthesis from hercynine" EXACT []
synonym: "ergothioneine biosynthesis from histidine betaine" EXACT []
synonym: "hercynine catabolism to ergothioneine" EXACT []
synonym: "histidine betaine catabolism to ergothioneine" EXACT []
synonym: "N-alpha,N-alpha,N-alpha-trimethyl-L-histidine catabolism to ergothioneine" EXACT []
xref: KEGG:R04878
is_a: GO:0052699 ! ergothioneine biosynthetic process
is_a: GO:0052710 ! N-alpha,N-alpha,N-alpha-trimethyl-L-histidine catabolic process
creation_date: 2011-08-05T04:06:16Z

[Term]
id: GO:0052712
name: inositol phosphosphingolipid phospholipase activity
namespace: molecular_function
def: "Catalysis of the reaction: inositol phosphosphingolipid + H2O = sphingolipid + phosphorylinositol." [GOC:ai]
xref: EC:3.1.4.-
is_a: GO:0004629 ! phospholipase C activity
created_by: gwg
creation_date: 2011-08-05T04:49:13Z

[Term]
id: GO:0052713
name: inositol phosphorylceramide phospholipase activity
namespace: molecular_function
def: "Catalysis of the reaction: inositol phosphorylceramide + H2O = C26-phytoceramide + phosphorylinositol." [GOC:ai]
xref: EC:3.1.4.-
is_a: GO:0052712 ! inositol phosphosphingolipid phospholipase activity
created_by: gwg
creation_date: 2011-08-05T04:51:03Z

[Term]
id: GO:0052714
name: mannosyl-inositol phosphorylceramide phospholipase activity
namespace: molecular_function
def: "Catalysis of the reaction: mannosyl-inositol phosphorylceramide + H2O = C26-phytoceramide + mannosylphosphorylinositol." [GOC:ai]
xref: EC:3.1.4.-
is_a: GO:0052713 ! inositol phosphorylceramide phospholipase activity
created_by: gwg
creation_date: 2011-08-05T08:02:57Z

[Term]
id: GO:0052715
name: mannosyl-diinositol phosphorylceramide phospholipase activity
namespace: molecular_function
def: "Catalysis of the reaction: mannosyl-diinositol phosphorylceramide + H2O = C26-phytoceramide + mannosyldiphosphorylinositol." [GOC:ai]
xref: EC:3.1.4.-
is_a: GO:0052713 ! inositol phosphorylceramide phospholipase activity
created_by: gwg
creation_date: 2011-08-05T08:02:57Z

[Term]
id: GO:0052716
name: hydroquinone:oxygen oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4 hydroquinone + O2 = 4 benzosemiquinone + 4 H2O." [EC:1.10.3.2]
synonym: "benzenediol:oxygen oxidoreductase activity" BROAD []
synonym: "laccase reaction" BROAD []
synonym: "p-diphenol:oxygen oxidoreductase activity" EXACT []
xref: EC:1.10.3.2
xref: KEGG:R00083
xref: MetaCyc:LACCASE-RXN
is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
created_by: gwg
creation_date: 2011-08-11T03:18:19Z

[Term]
id: GO:0052717
name: tRNA-specific adenosine-34 deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: adenosine-34 + H2O = inosine-34 + NH3, in a tRNA-Ala molecule." [PMID:17875641]
subset: gosubset_prok
synonym: "tRNA(Ala)-A34 deaminase activity" EXACT []
xref: EC:3.5.4.-
is_a: GO:0008251 ! tRNA-specific adenosine deaminase activity
created_by: gwg
creation_date: 2011-08-12T11:48:54Z

[Term]
id: GO:0052718
name: tRNA-specific adenosine-34 deaminase complex
namespace: cellular_component
def: "A protein complex that possesses tRNA-specific adenosine-34 deaminase activity. In eukaryotes the complex is a heterodimer; the subunits are known as Tad2p and Tad3p in yeasts and Adat2 and Adat3 in human." [PMID:17875641]
synonym: "tRNA-A34 deaminase complex" EXACT []
is_a: GO:0044424 ! intracellular part
is_a: GO:1902494 ! catalytic complex
created_by: gwg
creation_date: 2011-08-12T11:53:26Z

[Term]
id: GO:0052719
name: apurinic/apyrimidinic endoribonuclease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages immediately 5' to an apurinic/apyrimidinic (AP; also called abasic) site within a ribonucleic acid molecule by creating internal breaks, generating a single-strand break with 5'-ribose phosphate and 3'-hydroxyl ends." [PMID:19401441]
synonym: "abasic endoribonuclease activity" EXACT []
synonym: "AP endoribonuclease activity" EXACT []
synonym: "apurinic endoribonuclease activity" NARROW []
synonym: "apyrimidinic endoribonuclease activity" NARROW []
is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0052720
name: apurinic/apyrimidinic endodeoxyribonuclease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages immediately 5' to an apurinic/apyrimidinic (AP; also called abasic) site within a deoxyribonucleic acid molecule by creating internal breaks, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends." [PMID:19401441]
synonym: "abasic deoxyendoribonuclease activity" EXACT []
synonym: "AP deoxyendoribonuclease activity" EXACT []
synonym: "apurinic deoxyendoribonuclease activity" NARROW []
synonym: "apyrimidinic deoxyendoribonuclease activity" NARROW []
is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0052721
name: regulation of apurinic/apyrimidinic endodeoxyribonuclease activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of apurinic/apyrimidinic (AP) endodeoxyribonuclease activity, the hydrolysis of ester linkages immediately 5' to an AP (also called abasic) site within a deoxyribonucleic acid molecule by creating internal breaks, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends." [PMID:19401441]
synonym: "regulation of abasic endodeoxyribonuclease activity" EXACT []
synonym: "regulation of AP endodeoxyribonuclease activity" EXACT []
synonym: "regulation of apurinic endodeoxyribonuclease activity" NARROW []
synonym: "regulation of apyrimidinic endodeoxyribonuclease activity" NARROW []
is_a: GO:0032071 ! regulation of endodeoxyribonuclease activity
relationship: regulates GO:0052720 ! apurinic/apyrimidinic endodeoxyribonuclease activity

[Term]
id: GO:0052722
name: fatty acid in-chain hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: fatty acid + O2 + 2 NADPH + H+ = fatty acid with in-chain hydroxy group + 2 NADP+ + H2O." [MetaCyc:RXN-12186]
xref: MetaCyc:RXN-12186
is_a: GO:0004497 ! monooxygenase activity
created_by: gwg
creation_date: 2011-08-15T01:41:07Z

[Term]
id: GO:0052723
name: inositol hexakisphosphate 1-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 1-diphospho-1D-myo-inositol (2,3,4,5,6)pentakisphosphate." [GOC:jp, PMID:18981179]
xref: EC:2.7.4.21
xref: KEGG:R05799
xref: MetaCyc:RXN-10972
is_a: GO:0000828 ! inositol hexakisphosphate kinase activity
created_by: gwg
creation_date: 2011-08-16T11:47:36Z

[Term]
id: GO:0052724
name: inositol hexakisphosphate 3-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 3-diphospho-1D-myo-inositol (1,2,4,5,6)pentakisphosphate." [GOC:jp, PMID:18981179]
xref: EC:2.7.4.21
xref: MetaCyc:RXN-10971
is_a: GO:0000828 ! inositol hexakisphosphate kinase activity
created_by: gwg
creation_date: 2011-08-16T11:50:48Z

[Term]
id: GO:0052725
name: inositol-1,3,4-trisphosphate 6-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + 2 H(+)." [EC:2.7.1.134]
synonym: "1D-myo-inositol-trisphosphate 6-kinase activity" BROAD []
synonym: "ATP:1D-myo-inositol-1,3,4-trisphosphate 6-phosphotransferase activity" EXACT [EC:2.7.1.127]
synonym: "inositol 1,3,4-trisphosphate 6-kinase activity" EXACT []
synonym: "inositol-trisphosphate 6-kinase activity" BROAD []
synonym: "ins(1,3,4)P(3) 6-kinase activity" EXACT [EC:2.7.1.127]
synonym: "Ins(1,3,4)P3 6-kinase activity" EXACT [EC:2.7.1.127]
synonym: "IP3 6-kinase activity" BROAD [EC:2.7.1.127]
xref: EC:2.7.1.159
xref: MetaCyc:2.7.1.133-RXN
is_a: GO:0051766 ! inositol trisphosphate kinase activity
created_by: gwg
creation_date: 2011-08-16T12:42:59Z

[Term]
id: GO:0052726
name: inositol-1,3,4-trisphosphate 5-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H(+)." [EC:2.7.1.134]
synonym: "1D-myo-inositol-trisphosphate 5-kinase activity" BROAD []
synonym: "ATP:1D-myo-inositol-1,3,4-trisphosphate 5-phosphotransferase activity" EXACT [EC:2.7.1.127]
synonym: "inositol 1,3,4-trisphosphate 5-kinase activity" EXACT []
synonym: "inositol-trisphosphate 5-kinase activity" BROAD []
synonym: "ins(1,3,4)P(3) 5-kinase activity" EXACT [EC:2.7.1.127]
synonym: "Ins(1,3,4)P3 5-kinase activity" EXACT [EC:2.7.1.127]
synonym: "IP3 5-kinase activity" BROAD [EC:2.7.1.127]
xref: EC:2.7.1.159
xref: KEGG:R03428
xref: MetaCyc:2.7.1.139-RXN
is_a: GO:0051766 ! inositol trisphosphate kinase activity
created_by: gwg
creation_date: 2011-08-16T12:43:11Z

[Term]
id: GO:0052727
name: capsanthin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: antheraxanthin = capsanthin." [EC:5.3.99.8]
synonym: "capsanthin-capsorubin synthase activity" BROAD [EC:5.3.99.8]
synonym: "CCS" RELATED [EC:5.3.99.8]
synonym: "ketoxanthophyll synthase activity" BROAD [EC:5.3.99.8]
xref: EC:5.3.99.8
xref: MetaCyc:RXN-7947
is_a: GO:0016860 ! intramolecular oxidoreductase activity
created_by: gwg
creation_date: 2011-08-16T03:09:21Z

[Term]
id: GO:0052728
name: capsorubin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: violaxanthin = capsorubin." [EC:5.3.99.8]
synonym: "capsanthin-capsorubin synthase activity" BROAD [EC:5.3.99.8]
synonym: "CCS" RELATED [EC:5.3.99.8]
synonym: "ketoxanthophyll synthase activity" BROAD [EC:5.3.99.8]
synonym: "violaxanthin-capsorubin isomerase (ketone-forming) activity" EXACT [EC:5.3.99.8]
xref: EC:5.3.99.8
xref: MetaCyc:RXN-7946
is_a: GO:0016860 ! intramolecular oxidoreductase activity
created_by: gwg
creation_date: 2011-08-16T03:09:26Z

[Term]
id: GO:0052729
name: dimethylglycine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + N,N-dimethylglycine = S-adenosyl-L-homocysteine + betaine." [EC:2.1.1.157]
synonym: "ApDMT" RELATED [EC:2.1.1.157]
synonym: "S-adenosyl-L-methionine:N,N-dimethylglycine N-methyltransferase activity" EXACT [EC:2.1.1.157]
xref: EC:2.1.1.157
xref: EC:2.1.1.161
xref: EC:2.1.1.162
xref: KEGG:R07244
xref: MetaCyc:R482-RXN
xref: MetaCyc:RXN-9680
xref: RHEA:10075
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
created_by: gwg
creation_date: 2011-08-16T03:45:16Z

[Term]
id: GO:0052730
name: sarcosine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + sarcosine = S-adenosyl-L-homocysteine + N,N-dimethylglycine." [EC:2.1.1.157]
synonym: "S-adenosyl-L-methionine:N,N-sarcosine N-methyltransferase activity" EXACT [EC:2.1.1.157]
synonym: "SDMT" RELATED [EC:2.1.1.157]
xref: EC:2.1.1.156
xref: EC:2.1.1.157
xref: EC:2.1.1.162
xref: KEGG:R07243
xref: MetaCyc:R481-RXN
xref: MetaCyc:RXN-7042
xref: MetaCyc:RXN-9679
xref: RHEA:15456
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
created_by: gwg
creation_date: 2011-08-16T03:45:39Z

[Term]
id: GO:0052731
name: phosphocholine phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: choline phosphate + H2O = choline + phosphate." [EC:3.1.3.75]
synonym: "3X11A" RELATED [EC:3.1.3.75]
synonym: "PHOSPHO1" RELATED [EC:3.1.3.75]
synonym: "phosphoethanolamine phosphohydrolase activity" RELATED [EC:3.1.3.75]
xref: EC:3.1.3.75
xref: KEGG:R06871
xref: MetaCyc:RXN-5647
xref: RHEA:10495
is_a: GO:0016791 ! phosphatase activity
created_by: gwg
creation_date: 2011-08-16T04:09:06Z

[Term]
id: GO:0052732
name: phosphoethanolamine phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: O-phosphoethanolamine + H2O = ethanolamine + phosphate." [EC:3.1.3.75]
synonym: "3X11A" RELATED [EC:3.1.3.75]
synonym: "PHOSPHO1" RELATED [EC:3.1.3.75]
synonym: "phosphoethanolamine phosphohydrolase activity" EXACT [EC:3.1.3.75]
xref: EC:3.1.3.75
xref: KEGG:R06870
xref: MetaCyc:RXN-7948
xref: RHEA:16092
is_a: GO:0016791 ! phosphatase activity
created_by: gwg
creation_date: 2011-08-16T04:09:19Z

[Term]
id: GO:0052733
name: quinate 3-dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: quinate + NADP+ = 3-dehydroquinate + NADPH + H+." [RHEA:18428]
synonym: "quinate:NADP 3-oxidoreductase activity" EXACT [EC:1.1.1.24]
synonym: "quinate:NADP(+) 3-oxidoreductase activity" EXACT [EC:1.1.1.24]
synonym: "quinic dehydrogenase activity" BROAD [EC:1.1.1.24]
xref: EC:1.1.1.282
xref: KEGG:R06846
xref: RHEA:18428
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
created_by: gwg
creation_date: 2011-08-16T04:23:47Z

[Term]
id: GO:0052734
name: shikimate 3-dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: shikimate + NAD+ = 3-dehydroshikimate + NADH + H+." [RHEA:17744]
subset: gosubset_prok
synonym: "3-dehydroshikimate reductase activity" EXACT [EC:1.1.1.25]
synonym: "3-dehydroshikimic reductase activity" EXACT [EC:1.1.1.25]
synonym: "dehydroshikimic reductase activity" BROAD [EC:1.1.1.25]
synonym: "DHS reductase activity" BROAD [EC:1.1.1.25]
synonym: "shikimate oxidoreductase activity" BROAD [EC:1.1.1.25]
synonym: "shikimate:NAD(P)(+) 3-oxidoreductase activity" EXACT [EC:1.1.1.25]
synonym: "shikimate:NAD(P)(+) oxidoreductase activity" BROAD [EC:1.1.1.25]
xref: EC:1.1.1.282
xref: KEGG:R06847
xref: RHEA:17744
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
created_by: gwg
creation_date: 2011-08-16T04:28:23Z

[Term]
id: GO:0052735
name: tRNA (cytosine-3-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 3-methylcytosine." [PMID:21518804, PMID:21518805]
synonym: "S-adenosyl-L-methionine:tRNA (cytosine-3-)-methyltransferase activity" EXACT []
synonym: "S-adenosyl-L-methionine:tRNA cytosine-3-methyltransferase activity" EXACT []
synonym: "transfer ribonucleate cytosine 3-methyltransferase activity" EXACT []
synonym: "tRNA (cytosine 3)-methyltransferase activity" EXACT []
synonym: "tRNA cytosine 3-methyltransferase activity" EXACT []
synonym: "tRNA cytosine-3-methyltransferase activity" EXACT []
xref: EC:2.1.1.-
is_a: GO:0016427 ! tRNA (cytosine) methyltransferase activity

[Term]
id: GO:0052736
name: beta-glucanase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of linkages in beta-D-glucans; beta-glucans are polysaccharides of D-glucose monomers linked by beta-glycosidic bonds." [Wikipedia:Beta-glucan]
synonym: "beta-D-glucanase activity" EXACT []
xref: EC:3.2.1.-
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds
creation_date: 2011-08-19T03:40:56Z

[Term]
id: GO:0052737
name: pyruvate dehydrogenase (quinone) activity
namespace: molecular_function
def: "Catalysis of the reaction: a ubiquinone + H2O + pyruvate = a ubiquinol + acetate + CO2." [EC:1.2.5.1]
synonym: "pyruvate dehydrogenase activity" BROAD [EC:1.2.5.1]
synonym: "pyruvate:ubiquinone oxidoreductase activity" EXACT systematic_synonym [EC:1.2.5.1]
synonym: "pyruvate:ubiquinone-8-oxidoreductase activity" EXACT [EC:1.2.5.1]
synonym: "pyruvic dehydrogenase activity" BROAD [EC:1.2.5.1]
xref: EC:1.2.5.1
xref: KEGG:R03145
xref: MetaCyc:RXN-11496
xref: RHEA:27408
is_a: GO:0052738 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, with a quinone or similar compound as acceptor

[Term]
id: GO:0052738
name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, with a quinone or similar compound as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a quinone or similar compound." [EC:1.2.5]
xref: EC:1.2.5
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0052739
name: phosphatidylserine 1-acylhydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphatidylserine + H2O = 2-acyl-sn-glycero-3-phosphoserine + fatty acid." [KEGG:R04034]
synonym: "phosphatidylserine-specific phospholipase A1 activity" BROAD [EC:3.1.1.32]
xref: EC:3.1.1.32
xref: KEGG:R04034
is_a: GO:0004620 ! phospholipase activity
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0052740
name: 1-acyl-2-lysophosphatidylserine acylhydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-acyl-2-lysophosphatidylserine + H2O = sn-glycerol-phosphoserine + a carboxylate." [BRENDA:3.1.1.32]
synonym: "phosphatidylserine-specific phospholipase A1 activity" BROAD [EC:3.1.1.32]
xref: EC:3.1.1.32
is_a: GO:0004620 ! phospholipase activity
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0052741
name: (R)-limonene 6-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (4R)-limonene + H+ + NADPH + O2 = (1R,5S)-carveol + H2O + NADP+." [EC:1.14.13.80, RHEA:18960]
synonym: "(+)-limonene 6-monooxygenase activity" EXACT [EC:1.14.13.80]
synonym: "(+)-limonene-6-hydroxylase activity" EXACT [EC:1.14.13.80]
synonym: "(R)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating) activity" EXACT systematic_synonym [EC:1.14.13.80]
xref: EC:1.14.13.80
xref: KEGG:R06119
xref: MetaCyc:1.14.13.84-RXN
xref: RHEA:18960
is_a: GO:0019113 ! limonene monooxygenase activity

[Term]
id: GO:0052742
name: phosphatidylinositol kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate." [GOC:ai]
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
relationship: part_of GO:0046854 ! phosphatidylinositol phosphorylation
created_by: gwg
creation_date: 2011-09-14T01:21:47Z

[Term]
id: GO:0052743
name: inositol tetrakisphosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: myo-inositol tetrakisphosphate + H2O = myo-inositol trisphosphate + phosphate." [GOC:ai]
is_a: GO:0052745 ! inositol phosphate phosphatase activity
created_by: gwg
creation_date: 2011-09-14T01:31:39Z

[Term]
id: GO:0052744
name: phosphatidylinositol monophosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphatidylinositol monophosphate + H2O = phosphatidylinositol + phosphate." [GOC:ai]
subset: gosubset_prok
is_a: GO:0052866 ! phosphatidylinositol phosphate phosphatase activity
created_by: gwg
creation_date: 2011-09-14T01:36:39Z

[Term]
id: GO:0052745
name: inositol phosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: inositol phosphate(n) + H2O = inositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from an inositol phosphate." [GOC:ai]
xref: EC:3.1.3.-
is_a: GO:0016791 ! phosphatase activity
created_by: gwg
creation_date: 2011-09-14T01:50:04Z

[Term]
id: GO:0052746
name: inositol phosphorylation
namespace: biological_process
def: "The process of introducing one or more phosphate groups into inositol. Inositol is the cyclic alcohol 1,2,3,4,5,6-cyclohexanehexol, which is widely distributed in nature and acts as a growth factor in animals and microorganisms." [CHEBI:24848, ISBN:0198506732]
subset: gosubset_prok
synonym: "inositol and derivative phosphorylation" RELATED [GOC:curators]
synonym: "myo-inositol and derivative phosphorylation" RELATED []
synonym: "myo-inositol phosphorylation" NARROW [GOC:curators]
is_a: GO:0006020 ! inositol metabolic process
is_a: GO:0046835 ! carbohydrate phosphorylation
created_by: gwg
creation_date: 2011-09-14T01:55:23Z

[Term]
id: GO:0052747
name: sinapyl alcohol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: sinapaldehyde + NADPH + H+ = sinapyl-alcohol + NADP+." [GOC:mengo_curators, MetaCyc:RXN-1125]
synonym: "sinapyl-alcohol dehydrogenase activity" EXACT [EC:1.1.1.195]
synonym: "sinapyl-alcohol:NADP+ oxidoreductase activity" EXACT systematic_synonym [EC:1.1.1.195]
xref: EC:1.1.1.195
xref: KEGG:R03918
xref: MetaCyc:RXN-1125
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
creation_date: 2011-09-21T12:42:06Z

[Term]
id: GO:0052748
name: baicalin beta-D-glucuronidase activity
namespace: molecular_function
def: "Catalysis of the reaction: baicalin + H2O = baicalein + D-glucuronate." [GOC:mengo_curators, RHEA:28133]
synonym: "5,6,7-trihydroxyflavone-7-O-beta-D-glucupyranosiduronate glucuronosylhydrolase activity" EXACT [EC:3.2.1.167]
synonym: "baicalinase activity" BROAD [EC:3.2.1.167]
xref: EC:3.2.1.167
xref: KEGG:R09533
xref: MetaCyc:RXN-11760
xref: RHEA:28133
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds
created_by: gwg
creation_date: 2011-09-21T12:58:43Z

[Term]
id: GO:0052749
name: glucose-6-phosphate dehydrogenase (coenzyme F420) activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-D-glucose 6-phosphate + coenzyme F420 + H+ = 6-O-phosphono-D-glucono-1,5-lactone + reduced coenzyme F420." [EC:1.1.98.2, GOC:mengo_curators, RHEA:27297]
synonym: "coenzyme F420-dependent glucose-6-phosphate dehydrogenase activity" EXACT [EC:1.1.98.2]
synonym: "D-glucose-6-phosphate:F420 1-oxidoreductase activity" EXACT systematic_synonym [EC:1.1.98.2]
synonym: "F420-dependent glucose-6-phosphate dehydrogenase activity" EXACT [EC:1.1.98.2]
xref: EC:1.1.98.2
xref: KEGG:R09550
xref: MetaCyc:RXN-11283
xref: RHEA:27297
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors
created_by: gwg
creation_date: 2011-09-21T01:21:54Z

[Term]
id: GO:0052750
name: reactive-black-5:hydrogen-peroxide oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: reactive black 5 + hydrogen peroxide = oxidized reactive black 5 + 2 H2O." [KEGG:R07612, MetaCyc:RXN-8666]
synonym: "versatile peroxidase activity" BROAD [EC:1.11.1.16]
xref: EC:1.11.1.16
xref: KEGG:R07612
xref: MetaCyc:RXN-8666
is_a: GO:0004601 ! peroxidase activity
created_by: gwg
creation_date: 2011-09-21T02:33:34Z

[Term]
id: GO:0052751
name: GDP-mannose hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-mannose + H2O = GMP + mannose-1-phosphate." [PMID:16766526]
synonym: "GDP-mannose pyrophosphatase activity" RELATED [PMID:16766526]
is_a: GO:0016462 ! pyrophosphatase activity
created_by: gwg
creation_date: 2011-09-21T04:11:30Z

[Term]
id: GO:0052752
name: reduced coenzyme F420:heterodisulfide oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: reduced coenzyme F420 + CoB-S-S-CoM = coenzyme F420 + CoM-SH + CoB-SH." [GOC:mengo_curators, PMID:9914308]
synonym: "coenzyme F420-dependent heterodisulfide oxidoreductase activity" EXACT [PMID:9914308]
synonym: "F420-dependent heterodisulfide oxidoreductase activity" EXACT [PMID:9914308]
synonym: "F420H2:heterodisulfide oxidoreductase activity" EXACT []
is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors
created_by: gwg
creation_date: 2011-09-21T04:21:16Z

[Term]
id: GO:0052753
name: propan-2-ol:coenzyme F420 oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: propan-2-ol + coenzyme F420 = acetone + reduced coenzyme F420." [GOC:mengo_curators, PMID:15016352, PMID:1879431, PMID:8706724]
synonym: "F420-dependent propan-2-ol dehydrogenase activity" EXACT []
synonym: "F420-dependent secondary alcohol dehydrogenase activity" BROAD []
synonym: "isopropanol:coenzyme F420 oxidoreductase activity" EXACT []
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors
creation_date: 2011-09-21T05:15:28Z

[Term]
id: GO:0052754
name: GTP:coenzyme F420 guanyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP + factor gamma-F420-2 + H+ = coenzyme F390-G + diphosphate." [GOC:mengo_curators, MetaCyc:MONOMER-13942, MetaCyc:RXN-9385]
synonym: "coenzyme F390-G synthetase activity" EXACT []
synonym: "GTP:coenzyme F420 guanylyltransferase activity" EXACT []
is_a: GO:0070568 ! guanylyltransferase activity
created_by: gwg
creation_date: 2011-09-22T03:25:30Z

[Term]
id: GO:0052755
name: reduced coenzyme F420:quinone oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: reduced coenzyme F420 + 2,3-dimethyl-1,4-naphthoquinone = coenzyme F420 + reduced 2,3-dimethyl-1,4-naphthoquinone. Reduced 2,3-dimethyl-1,4-naphthoquinone is also known as 2,3-dimethyl-1,4-hydronaphthoquinone." [GOC:mengo_curators, PMID:10971593, PMID:8055920]
synonym: "F420H2-dependent quinone oxidoreductase activity" EXACT []
synonym: "F420H2:2,3-dimethyl-1,4-naphthoquinone oxidoreductase activity" EXACT []
synonym: "F420H2:quinone oxidoreductase activity" EXACT []
is_a: GO:0016491 ! oxidoreductase activity
created_by: gwg
creation_date: 2011-09-22T04:08:13Z

[Term]
id: GO:0052756
name: chitobiose phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: chitobiose + phosphate = N-acetyl-D-glucosamine + N-acetyl-alpha-D-glucosamine 1-phosphate. This reaction is the phosphorolysis of chitobiose, (GlcNAc)2, a dimer of beta-(1->4) linked glucosamine units." [GOC:mengo_curators, PMID:15274915, Wikipedia:chitobiose]
is_a: GO:0004645 ! phosphorylase activity
created_by: gwg
creation_date: 2011-09-27T04:04:53Z

[Term]
id: GO:0052757
name: chondroitin hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of hexosaminic linkages in chondroitin, a linear polymer structure composed of the repeating disaccharide unit [->4)-D-glucuronic acid-(1->3)-N-acetyl-D-galactosamine-(1-], also written as [->4GlcUA1->3GalNAc1-]." [GOC:mengo_curators, PMID:18390555]
synonym: "chondroitin endo-beta-galactosaminidase activity" EXACT [PMID:18390555]
xref: EC:2.4.1.-
is_a: GO:0033931 ! endogalactosaminidase activity
created_by: gwg
creation_date: 2011-09-28T10:31:53Z

[Term]
id: GO:0052758
name: coenzyme F420-dependent 2,4,6-trinitrophenol reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4,6-trinitrophenol + H- = 2,4,6-trinitrophenol hydride Meisenheimer complex. Coenzyme F420 supplies the hydride (H-) in the reaction." [GOC:mengo_curators, PMID:11995829, UM-BBD_reactionID:r1065]
synonym: "coenzyme F420-dependent 2,4,6-trinitrophenol hydride transferase activity" EXACT []
synonym: "TNP reductase activity" BROAD []
xref: EC:1.3.99.-
xref: UM-BBD_reactionID:r1065
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors
created_by: gwg
creation_date: 2011-09-28T11:06:03Z

[Term]
id: GO:0052759
name: coenzyme F420-dependent 2,4,6-trinitrophenol hydride reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: trinitrophenol hydride Meisenheimer complex + H- = trinitrophenol dihydride Meisenheimer complex (aci form). Coenzyme F420 supplies the hydride (H-) in the reaction." [GOC:mengo_curators, UM-BBD_reactionID:r1066]
synonym: "coenzyme F420-dependent 2,4,6-trinitrophenol-hydride-Meisenheimer-complex hydride transferase activity" EXACT []
xref: EC:1.3.99.-
xref: UM-BBD_reactionID:r1066
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors
creation_date: 2011-09-28T01:50:17Z

[Term]
id: GO:0052760
name: coenzyme F420-dependent 2,4-dinitrophenol reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4-dinitrophenol + H- = 2,4-dinitrophenol hydride Meisenheimer complex. Coenzyme F420 supplies the hydride (H-) in the reaction." [GOC:mengo_curators, PMID:11995829, UM-BBD_reactionID:r1071]
synonym: "coenzyme F420-dependent 2,4-dinitrophenol hydride transferase activity" EXACT []
synonym: "DNP reductase activity" BROAD []
xref: EC:1.3.99.-
xref: UM-BBD_reactionID:r1071
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors
created_by: gwg
creation_date: 2011-09-28T02:47:31Z

[Term]
id: GO:0052761
name: exo-1,4-beta-D-glucosaminidase activity
namespace: molecular_function
def: "Catalysis of the reaction: [beta-(1->4)-D-glucosamine]n-[N-acetyl-D-glucosamine]m = D-glucosamine + [beta-(1->4)-D-glucosamine](n-1)-[N-acetyl-D-glucosamine]m. This reaction is the hydrolysis of chitosan or chitosan oligosaccharides to remove a D-glucosamine residue from the non-reducing termini; chitosan is a linear polysaccharide composed of randomly distributed beta-(1->4)-linked D-glucosamine and N-acetyl-D-glucosamine units." [EC:3.2.1.165, GOC:mengo_curators, MetaCyc:3.2.1.165-RXN]
synonym: "chitosan exo-1,4-beta-D-glucosaminidase activity" EXACT [KEGG:R08715]
synonym: "chitosan glucosaminohydrolase activity" EXACT [KEGG:R08715]
synonym: "exo-beta-D-glucosaminidase activity" EXACT [EC:3.2.1.165]
synonym: "exochitosanase activity" EXACT [EC:3.2.1.165]
xref: EC:3.2.1.165
xref: KEGG:R08715
xref: MetaCyc:3.2.1.165-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds
created_by: gwg
creation_date: 2011-09-28T03:30:54Z

[Term]
id: GO:0052762
name: gellan lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: gellan = n beta-D-4-deoxy-delta4,5-GlcAp-(1->4)-beta-D-Glcp-(1->4)-alpha-L-Rhap-(1->3)-beta-D-Glcp. This reaction is the eliminative cleavage of beta-D-glucopyranosyl-(1->4)-beta-D-glucopyranosyluronate bonds of gellan backbone, releasing tetrasaccharides containing a 4-deoxy-4,5-unsaturated D-glucopyranosyluronic acid at the non-reducing end; in the product, the abbreviations are D-glucose (Glc), D-glucuronic acid (GlcA), and L-rhamnose (Rha)." [GOC:mengo_curators, MetaCyc:RXN-12269]
xref: EC:4.2.2.-
xref: MetaCyc:RXN-12269
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides
created_by: gwg
creation_date: 2011-09-29T03:19:25Z

[Term]
id: GO:0052763
name: ulvan lyase activity
namespace: molecular_function
def: "Catalysis of the cleavage of a carbon-oxygen bond in ulvan, a carbohydrate composed of a repeating structure of [->4)-beta-D-GlcA-(1,4)-alpha-L-Rha 3S-(1->4)-alpha-L-IdoA-(1->4)-alpha-L-Rha 3S-(1-]n. Continued digest of ulvan with an enzyme that can catalyze this reaction results in ulvanobiouronic acid A 3-sulfate [->4)-beta-D-GlcpA-(1->4)-alpha-L-Rhap 3-sulfate-(1-]n with 4-deoxy-L-threo-hex-4-enopyranosiduronic acid at the non-reducing end." [GOC:mengo_curators, PMID:9468631]
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides
created_by: gwg
creation_date: 2011-09-29T03:39:23Z

[Term]
id: GO:0052764
name: exo-oligoalginate lyase activity
namespace: molecular_function
def: "Catalysis of the cleavage of glycosidic bonds through a beta-elimination reaction on alginate, a linear polysaccharide consisting of guluronate (G) and mannuronate (M) as the monomer constituents. An oligoalginate is a linear polymer of two, three or four units of (1->4)-alpha-L-guluronic acid and beta-D-mannuronic acid, releasing monosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl groups at their ends." [GOC:mengo_curators, PMID:20925655]
xref: EC:4.2.2.-
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides
created_by: gwg
creation_date: 2011-09-29T04:05:44Z

[Term]
id: GO:0052765
name: reduced coenzyme F420 oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 reduced coenzyme F420 + O2 = 2 coenzyme F420 + 2 H2O." [GOC:mengo_curators, PMID:15340796]
synonym: "coenzyme F420H2 oxidase activity" EXACT []
synonym: "F420H2 oxidase activity" EXACT []
synonym: "F420H2:oxygen oxidoreductase activity" EXACT []
is_a: GO:0016491 ! oxidoreductase activity
created_by: gwg
creation_date: 2011-09-29T04:33:54Z

[Term]
id: GO:0052766
name: mannoside alpha-1,4-mannosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the alpha-(1->4) linkage of the terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides." [GOC:mengo_curators, PMID:20081828]
synonym: "alpha-1,4-exomannosidase activity" BROAD []
synonym: "alpha-1,4-mannosidase activity" BROAD []
synonym: "mannoside alpha-1,4-exomannosidase activity" EXACT []
synonym: "mannoside exo-alpha-1,4-mannosidase activity" EXACT []
is_a: GO:0004559 ! alpha-mannosidase activity
created_by: gwg
creation_date: 2011-09-30T12:55:24Z

[Term]
id: GO:0052767
name: mannosyl-oligosaccharide 1,6-alpha-mannosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the alpha-(1->6) bonds of alpha-D-mannose residues in mannosyl-oligosaccharide." [GOC:mengo_curators, PMID:1849817, PMID:2338081]
synonym: "1,6-alpha-mannosidase activity" BROAD []
synonym: "1,6-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase activity" EXACT []
synonym: "alpha-1,6-mannosidase activity" BROAD []
synonym: "alpha-1,6-mannosyl-oligosaccharide alpha-D-mannohydrolase activity" EXACT []
xref: EC:3.1.1.-
is_a: GO:0015924 ! mannosyl-oligosaccharide mannosidase activity
created_by: gwg
creation_date: 2011-09-30T12:55:24Z

[Term]
id: GO:0052768
name: mannosyl-oligosaccharide 1,3-alpha-mannosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the alpha-(1->3) bonds of alpha-D-mannose residues in mannosyl-oligosaccharide." [GOC:mengo_curators, PMID:1849817, PMID:2338081]
synonym: "1,3-alpha-mannosidase activity" BROAD []
synonym: "1,3-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase activity" EXACT []
synonym: "alpha-1,3-mannosidase activity" BROAD []
synonym: "alpha-1,3-mannosyl-oligosaccharide alpha-D-mannohydrolase activity" EXACT []
xref: EC:3.1.1.-
is_a: GO:0015924 ! mannosyl-oligosaccharide mannosidase activity
created_by: gwg
creation_date: 2011-09-30T12:55:24Z

[Term]
id: GO:0052769
name: beta-6-sulfate-N-acetylglucosaminidase activity
namespace: molecular_function
def: "Catalysis of the glycosidic cleavage of the terminal 2-acetamido-2-deoxy-beta-D-glucopyranoside 6-sulfate (6-SO3-GlcNAc) residue from sulfomucin, a sulfated mucin derivative." [GOC:mengo_curators, PMID:15716424]
synonym: "beta-6-SO3-N-acetylglucosaminidase activity" BROAD []
synonym: "exosulfoglycosidase activity" BROAD []
synonym: "sulfoglycosidase activity" BROAD []
synonym: "sulfomucin beta-6-sulfate-N-acetylglucosaminidase activity" EXACT []
xref: EC:3.2.1.-
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds
created_by: gwg
creation_date: 2011-09-30T12:55:24Z

[Term]
id: GO:0052770
name: coenzyme F390-A hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: coenzyme F390-A = AMP + coenzyme F420." [GOC:mengo_curators, PMID:8536708, PMID:9352911]
synonym: "8-hydroxyadenylylated-coenzyme F420 hydrolase activity" EXACT []
xref: EC:3.-.-.-
is_a: GO:0016787 ! hydrolase activity
created_by: gwg
creation_date: 2011-10-03T12:00:00Z

[Term]
id: GO:0052771
name: coenzyme F390-G hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: coenzyme F390-G = GMP + coenzyme F420." [GOC:mengo_curators, PMID:8536708, PMID:9352911]
synonym: "8-hydroxyguanylylated-coenzyme F420 hydrolase activity" EXACT []
xref: EC:3.-.-.-
is_a: GO:0016787 ! hydrolase activity
created_by: gwg
creation_date: 2011-10-03T12:00:00Z

[Term]
id: GO:0052772
name: brefeldin A esterase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of brefeldin A to produce brefeldin A acid. Brefeldin A is also known as gamma,4-dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic acid lambda-lactone." [GOC:mengo_curators, PMID:10201402, PMID:8106385]
synonym: "BFA esterase activity" BROAD []
synonym: "brefeldin A hydrolase activity" EXACT []
is_a: GO:0052689 ! carboxylic ester hydrolase activity
created_by: gwg
creation_date: 2011-10-03T12:01:00Z

[Term]
id: GO:0052773
name: diacetylchitobiose deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N,N'-diacetylchitobiose (GlcNac2) + H2O = acetate + 2-acetamido-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-D-glucose (GlcN-GlcNAc)." [GOC:bf, GOC:mengo_curators, MetaCyc:RXN-12543, PMID:15136574, PMID:16232910, PMID:16736587]
comment: In this reaction N,N'-diacetylchitobiose is deacetylated at the non-reducing residue to produce 2-acetamido-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-D-glucose (GlcN-GlcNAc). This is in contrast to EC:3.5.1.105 in which N,N'-diacetylchitobiose is deacetylated at the reducing residue to produce 4-O-(N-acetyl-beta-D-glucosaminyl)-D-glucosamine (GlcNAc-GlcN). For the latter reaction, see GO:0036311.
synonym: "N,N'-diacetylchitobiose deacetylase (nonreducing end)" EXACT [MetaCyc:RXN-12543]
xref: EC:3.5.1.-
xref: MetaCyc:RXN-12543
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
created_by: gwg
creation_date: 2011-10-03T12:01:05Z

[Term]
id: GO:0052774
name: glucosyl-N-acetylglucosamine glucosaminidase activity
namespace: molecular_function
def: "Catalysis of the reaction: glucosyl-N-acetylglucosamine + H2O = glucosamine + N-acetylglucosamine." [GOC:mengo_curators, PMID:15136574, PMID:16232910, PMID:16736587]
is_a: GO:0015929 ! hexosaminidase activity
created_by: gwg
creation_date: 2011-10-03T12:01:05Z

[Term]
id: GO:0052775
name: endo-1,3-alpha-L-rhamnosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: R1-L-rhamnose-(1->3)-alpha-L-rhamnose-R2 + H2O = R1-L-rhamnose + L-rhamnose-R2. This reaction is the hydrolysis of an alpha-(1->3) linkage between two rhamnose residues in a polysaccharide chain." [GOC:mengo_curators, PMID:10439404]
synonym: "endo-(1,3)-alpha-L-rhamnosidase activity" EXACT []
synonym: "endo-(1->3)-alpha-L-rhamnosidase activity" EXACT []
synonym: "endorhamnosidase activity" BROAD []
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds
created_by: gwg
creation_date: 2011-10-05T03:30:33Z

[Term]
id: GO:0052776
name: diacetylchitobiose catabolic process to glucosamine and acetate
namespace: biological_process
def: "The pathway resulting in the breakdown of diacetylchitobiose into simpler products, including glucosamine and glucosamine. The catabolism proceeds by the deacetylation of diacetylchitobiose, producing acetate and GlcN-GlcNAc; the latter is cleaved to produce glucosamine (GlcN) and N-acetylglucosamine (GlcNAc). The N-acetylglucosamine (GlcNAc) is then deacetylated to produce glucosamine (GlcN) and acetate." [GOC:bf, GOC:mengo_curators, MetaCyc:PWY-6855, PMID:15136574, PMID:16232910, PMID:16736587]
is_a: GO:0006041 ! glucosamine metabolic process
is_a: GO:0006083 ! acetate metabolic process
is_a: GO:0044712 ! single-organism catabolic process
is_a: GO:0052777 ! diacetylchitobiose catabolic process
relationship: has_part GO:0050119 ! N-acetylglucosamine deacetylase activity
relationship: has_part GO:0052761 ! exo-1,4-beta-D-glucosaminidase activity
relationship: has_part GO:0052773 ! diacetylchitobiose deacetylase activity

[Term]
id: GO:0052777
name: diacetylchitobiose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of diacetylchitobiose into simpler products." [CHEBI:28681]
synonym: "diacetylchitobiose catabolism" EXACT [GOC:obol]
is_a: GO:0052778 ! diacetylchitobiose metabolic process
is_a: GO:0052782 ! amino disaccharide catabolic process

[Term]
id: GO:0052778
name: diacetylchitobiose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving diacetylchitobiose, the N,N'-diacetylated derivative of chitobiose." [CHEBI:28681]
synonym: "diacetylchitobiose metabolism" EXACT [GOC:obol]
is_a: GO:0052779 ! amino disaccharide metabolic process

[Term]
id: GO:0052779
name: amino disaccharide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any amino disaccharide, a disaccharide having one or more substituted or unsubstituted amino groups in place of hydroxy groups at unspecified positions." [CHEBI:22480]
is_a: GO:1901135 ! carbohydrate derivative metabolic process
creation_date: 2011-10-03T08:47:05Z

[Term]
id: GO:0052780
name: chitobiose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving chitobioses, a family of compounds derived from chitin and based on the structure of D-glucosaminyl-(1->4)-D-glucosamine." [CHEBI:50674]
is_a: GO:0052779 ! amino disaccharide metabolic process
created_by: gwg
creation_date: 2011-10-03T08:48:09Z

[Term]
id: GO:0052781
name: chitobiose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any chitobiose, a family of compounds derived from chitin and based on the structure of D-glucosaminyl-(1->4)-D-glucosamine." [CHEBI:50674]
is_a: GO:0052780 ! chitobiose metabolic process
is_a: GO:0052782 ! amino disaccharide catabolic process
created_by: gwg
creation_date: 2011-10-03T08:54:17Z

[Term]
id: GO:0052782
name: amino disaccharide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any amino disaccharide, a disaccharide having one or more substituted or unsubstituted amino groups in place of hydroxy groups at unspecified positions." [CHEBI:22480]
is_a: GO:0052779 ! amino disaccharide metabolic process
is_a: GO:1901136 ! carbohydrate derivative catabolic process
created_by: gwg
creation_date: 2011-10-03T08:56:04Z

[Term]
id: GO:0052783
name: reuteran metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving reuteran, a soluble glucan polymer with mainly alpha-(1->4) glycosidic linkages and significant amounts of alpha-(1->6) and alpha-(1->4,6) glucosidic linkages." [PMID:15256553, PMID:16000808]
is_a: GO:0030978 ! alpha-glucan metabolic process
created_by: gwg
creation_date: 2011-10-04T09:16:35Z

[Term]
id: GO:0052784
name: reuteran biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of reuteran, a soluble glucan polymer with mainly alpha-(1->4) glycosidic linkages and significant amounts of alpha-(1->6) and alpha-(1->4,6) glucosidic linkages." [GOC:mengo_curators, PMID:15256553, PMID:16000808]
synonym: "reuteransucrase-mediated reuteran biosynthesis" NARROW []
is_a: GO:0030979 ! alpha-glucan biosynthetic process
is_a: GO:0052783 ! reuteran metabolic process
created_by: gwg
creation_date: 2011-10-04T09:20:35Z

[Term]
id: GO:0052785
name: cellulose catabolism by endo-processive cellulases
namespace: biological_process
def: "The breakdown into simpler components of cellulose. Catabolism is initiated by endohydrolytic attacks on the cellulose chain, and the resulting pieces are further degraded by cellulase enzymes to produce smaller and smaller fragments." [GOC:mengo_curators, PMID:18035374]
synonym: "endo-processive cellulase activity" RELATED []
is_a: GO:0030245 ! cellulose catabolic process
created_by: gwg
creation_date: 2011-10-04T09:31:16Z

[Term]
id: GO:0052786
name: alpha-linked polysaccharide catabolism to maltotriose
namespace: biological_process
def: "The breakdown of large alpha-linked polysaccharides by hydrolysis of (1->4)-alpha-D-glucosidic linkages to yield maltotriose." [GOC:mengo_curators, PMID:7511484, PMID:9406414]
synonym: "alpha-amylase-mediated polysaccharide catabolism, producing maltotriose" EXACT []
synonym: "maltotriose-forming alpha-amylase activity" RELATED []
is_a: GO:0000272 ! polysaccharide catabolic process
created_by: gwg
creation_date: 2011-10-04T09:59:59Z

[Term]
id: GO:0052787
name: alpha-linked polysaccharide catabolism to maltopentaose
namespace: biological_process
def: "The breakdown of large alpha-linked polysaccharides by hydrolysis of (1->4)-alpha-D-glucosidic linkages to yield maltopentaose." [GOC:mengo_curators, PMID:7511484, PMID:9406414]
synonym: "alpha-amylase-mediated polysaccharide catabolism, producing maltopentaose" EXACT []
synonym: "maltopentaose-forming alpha-amylase activity" RELATED []
is_a: GO:0000272 ! polysaccharide catabolic process
created_by: gwg
creation_date: 2011-10-04T10:06:44Z

[Term]
id: GO:0052788
name: d-4,5 unsaturated beta-glucuronyl hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the glycosidic bond in an unsaturated saccharide between the unsaturated glucuronyl residue at the nonreducing terminus and the saccharide linked to the residue." [GOC:mengo_curators, PMID:12729728]
synonym: "unsaturated beta-glucuronyl hydrolase activity" EXACT []
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds
created_by: gwg
creation_date: 2011-10-04T12:59:37Z

[Term]
id: GO:0052789
name: mannan 1,3-beta-mannosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1->3)-beta-D-mannosidic linkages in mannans, releasing mannose." [EC:3.2.1.78, GOC:mengo_curators]
synonym: "1,3-beta-D-mannan mannanohydrolase activity" EXACT [EC:3.2.1.78]
synonym: "beta-1,3-mannan 3-mannanohydrolase activity" EXACT [EC:3.2.1.78]
synonym: "exo-1,3-beta-mannanase activity" EXACT [EC:3.2.1.78]
synonym: "exo-1,3-mannanase activity" EXACT [EC:3.2.1.78]
synonym: "exo-beta-1,3-mannase activity" EXACT [EC:3.2.1.78]
is_a: GO:0004567 ! beta-mannosidase activity
created_by: gwg
creation_date: 2011-10-04T01:11:41Z

[Term]
id: GO:0052790
name: chitooligosaccharide deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: chitooligosaccharide with N-acetylglucosamine at nonreducing terminal + H2O = chitooligosaccharide with glucosamine at nonreducing terminal + acetate. This reaction is the deacetylation of a chitooligosaccharide at the nonreducing N-acetylglucosamine residue; chitooligosaccharide are composed of (1->4)-linked D-glucosamine (GlcN) and N-acetyl-D-glucosamine (GlcNAc) in varying proportions." [GOC:mengo_curators, PMID:8421697, PMID:8986807]
xref: EC:3.5.1.-
is_a: GO:0052689 ! carboxylic ester hydrolase activity
created_by: gwg
creation_date: 2011-10-04T03:48:35Z

[Term]
id: GO:0052791
name: 3-deoxy-D-glycero-D-galacto-2-nonulosonic acid hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2-keto-3-deoxynononic acid)n + H2O = (2-keto-3-deoxynononic acid)n-1 + 2-keto-3-deoxynononic acid. This reaction is the hydrolysis of a 2-keto-3-deoxynononic acid residue from a poly-2-keto-3-deoxynononic acid chain." [GOC:mengo_curators, PMID:21247893]
synonym: "2-keto-3-deoxynononic acid sialidase activity" EXACT []
is_a: GO:0016997 ! alpha-sialidase activity
created_by: gwg
creation_date: 2011-10-04T04:53:49Z

[Term]
id: GO:0052792
name: endo-xylogalacturonan hydrolase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of xylogalacturonate by cleavage of the alpha-(1,4)-linkage. Xylogalacturonate (XGA) is composed of a chain of alpha-(1,4)-linked D-galacturonic acid residues with beta-D-xylose substituted at the O3 position." [GOC:mengo_curators, PMID:10618200]
synonym: "endo-galacturonase activity" BROAD []
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds
created_by: gwg
creation_date: 2011-10-05T03:57:30Z

[Term]
id: GO:0052793
name: pectin acetylesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: pectin + H2O = pectate + acetate. This reaction is the hydrolysis of acetyl esters of pectin, producing pectate, partially esterified pectin." [GOC:mengo_curators, PMID:9218776]
is_a: GO:0052689 ! carboxylic ester hydrolase activity
created_by: gwg
creation_date: 2011-10-05T05:17:21Z

[Term]
id: GO:0052794
name: exo-alpha-(2->3)-sialidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of alpha-(2->3)-glycosidic linkages of terminal sialic residues in substrates." [EC:3.2.1.18, GOC:mengo_curators]
synonym: "exo-alpha-(2,3)-sialidase activity" EXACT []
synonym: "exo-alpha-2,3-sialidase activity" EXACT []
xref: EC:3.2.1.18
is_a: GO:0004308 ! exo-alpha-sialidase activity

[Term]
id: GO:0052795
name: exo-alpha-(2->6)-sialidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of alpha-(2->6)-glycosidic linkages of terminal sialic residues in substrates." [EC:3.2.1.18, GOC:mengo_curators]
synonym: "exo-alpha-(2,6)-sialidase activity" EXACT []
synonym: "exo-alpha-2,6-sialidase activity" EXACT []
xref: EC:3.2.1.18
is_a: GO:0004308 ! exo-alpha-sialidase activity

[Term]
id: GO:0052796
name: exo-alpha-(2->8)-sialidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of alpha-(2->8)-glycosidic linkages of terminal sialic residues in substrates." [EC:3.2.1.18, GOC:mengo_curators]
synonym: "exo-alpha-(2,8)-sialidase activity" EXACT []
synonym: "exo-alpha-2,8-sialidase activity" EXACT []
xref: EC:3.2.1.18
is_a: GO:0004308 ! exo-alpha-sialidase activity

[Term]
id: GO:0052797
name: 4-O-methyl-glucuronoyl methylesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: [X]-4-O-methyl-D-glucuronic acid + H2O = [X]-OH + methyl-D-glucuronic acid. This reaction is the hydrolysis of the ester linkage between 4-O-methyl-D-glucuronic acid (MeGlcA) and an alcohol (-OH) group attached to a molecule, denoted here as [X]." [GOC:mengo_curators, PMID:16876163]
synonym: "glucuronoyl esterase activity" BROAD [PMID:16876163]
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0052798
name: beta-galactoside alpha-2,3-sialyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of sialyl residues alpha-2,3-linked to a beta galactosyl residue on the donor to form an alpha-2,3 linkage to a terminal beta galactosyl residue on the acceptor." [GOC:mengo_curators, PMID:7826016, PMID:8405811]
synonym: "trans-sialidase activity" BROAD []
is_a: GO:0008373 ! sialyltransferase activity

[Term]
id: GO:0052799
name: coenzyme F420-dependent bicyclic nitroimidazole catabolic process
namespace: biological_process
def: "The breakdown of a bicyclic nitroimidazole into simpler components in a process that requires coenzyme F420 and produces reactive nitrogen species. Hydride, from reduced coenzyme F420, is added to the bicyclic nitroimidazole, resulting in unstable substances that break down to form three stable products. The elimination of nitrous acid produces the corresponding des-nitroimidazole; hydrolysis produces a related compound; and further reduction creates an aromatic hydroxylamine metabolite that degrades further. These reactions release hyponitrous acid and nitrous acid, which is unstable and disproportionates into nitric oxide (NO) and other reactive nitrogen intermediates." [GOC:mengo_curators, PMID:16387854, PMID:19039139]
synonym: "coenzyme F420-dependent nitroimidazole breakdown" EXACT []
synonym: "coenzyme F420-dependent nitroimidazole catabolism" EXACT []
synonym: "coenzyme F420-dependent nitroimidazole reduction" EXACT []
synonym: "coenzyme F420-dependent nitroreductase activity" RELATED []
is_a: GO:0052800 ! bicyclic nitroimidazole catabolic process

[Term]
id: GO:0052800
name: bicyclic nitroimidazole catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a bicyclic nitroimidazole." [PMID:16387854, PMID:19039139]
synonym: "bicyclic nitroimidazole breakdown" EXACT []
synonym: "bicyclic nitroimidazole catabolism" EXACT []
synonym: "bicyclic nitroimidazole degradation" EXACT []
is_a: GO:0052801 ! bicyclic nitroimidazole metabolic process
is_a: GO:0052804 ! nitroimidazole catabolic process

[Term]
id: GO:0052801
name: bicyclic nitroimidazole metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving bicyclic nitroimidazoles, imidazole derivatives with two rings and a nitro group attached to one ring." [PMID:16387854, PMID:19039139]
synonym: "bicyclic nitroimidazole metabolism" EXACT []
is_a: GO:0052802 ! nitroimidazole metabolic process

[Term]
id: GO:0052802
name: nitroimidazole metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nitroimidazoles, imidazole derivatives with a nitro group attached to one ring." [PMID:16387854, PMID:19039139]
synonym: "nitroimidazole metabolism" EXACT []
is_a: GO:0052803 ! imidazole-containing compound metabolic process

[Term]
id: GO:0052803
name: imidazole-containing compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving imidazoles, five-membered organic heterocycle containing two nitrogen atoms at positions 1 and 3, or any of its derivatives; compounds containing an imidazole skeleton." [CHEBI:24780]
synonym: "imidazole metabolism" EXACT []
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0034641 ! cellular nitrogen compound metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process

[Term]
id: GO:0052804
name: nitroimidazole catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of nitroimidazoles, imidazole derivatives with a nitro group attached to one ring." [PMID:16387854, PMID:19039139]
synonym: "nitroimidazole breakdown" EXACT []
synonym: "nitroimidazole catabolism" EXACT []
synonym: "nitroimidazole degradation" EXACT []
is_a: GO:0052805 ! imidazole-containing compound catabolic process

[Term]
id: GO:0052805
name: imidazole-containing compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of imidazoles, five-membered organic heterocycle containing two nitrogen atoms at positions 1 and 3, or any of its derivatives; compounds containing an imidazole skeleton." [CHEBI:24780]
synonym: "imidazole breakdown" EXACT []
synonym: "imidazole catabolism" EXACT []
synonym: "imidazole degradation" EXACT []
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0044270 ! cellular nitrogen compound catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:0052803 ! imidazole-containing compound metabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process

[Term]
id: GO:0052806
name: sulfite reductase (coenzyme F420) activity
namespace: molecular_function
def: "Catalysis of the reaction: sulfite + 3 1,5-dihydrocoenzyme F420 = hydrogen sulfide + 3 H2O + 3 coenzyme F420. 1,5-dihydrocoenzyme F420 is also known as reduced coenzyme F420." [GOC:mengo_curators, PMID:16048999]
synonym: "coenzyme F420-dependent sulfite reductase activity" EXACT []
synonym: "coenzyme F420-sulfite reductase activity" EXACT []
synonym: "hydrogen-sulfide:coenzyme F420 oxidoreductase activity" EXACT []
synonym: "sulfite:reduced coenzyme F420 reductase activity" EXACT []
xref: EC:1.8.-.-
is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors
created_by: gwg
creation_date: 2011-09-22T04:08:13Z

[Term]
id: GO:0052807
name: aflatoxin reductase (coenzyme F420) activity
namespace: molecular_function
def: "Catalysis of the reaction: aflatoxin + 1,5-dihydrocoenzyme F420 = aflatoxin with reduced furanocoumarin moiety + coenzyme F420. 1,5-dihydrocoenzyme F420 is also known as reduced coenzyme F420." [GOC:mengo_curators, PMID:20807200]
synonym: "aflatoxin:coenzyme F420 oxidoreductase activity" EXACT []
synonym: "aflatoxin:reduced coenzyme F420 reductase activity" EXACT []
synonym: "coenzyme F420-aflatoxin reductase activity" EXACT []
synonym: "coenzyme F420-dependent aflatoxin reductase activity" EXACT []
xref: EC:1.8.-.-
is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors
created_by: gwg
creation_date: 2011-09-22T04:08:13Z

[Term]
id: GO:0052808
name: reduced coenzyme F420:NADP+ oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + 1,5-dihydrocoenzyme F420 = NADPH + H+ + coenzyme F420. 1,5-dihydrocoenzyme F420 is also known as reduced coenzyme F420." [GOC:mengo_curators, PMID:11726492]
synonym: "coenzyme F420-dependent NADP oxidoreductase activity" EXACT []
synonym: "coenzyme F420-dependent NADP reductase activity" EXACT []
synonym: "F420H2:NADP oxidoreductase activity" EXACT []
synonym: "F420H2:NADP+ oxidoreductase activity" EXACT []
synonym: "NADP+:F420 oxidoreductase activity" EXACT []
xref: EC:1.6.-.-
is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H
created_by: gwg
creation_date: 2011-09-22T04:08:13Z

[Term]
id: GO:0052809
name: acharan sulfate lyase activity
namespace: molecular_function
def: "Catalysis of the cleavage of a carbon-oxygen bond in acharan sulfate, a glycosaminoglycan with a uniformly repeating disaccharide structure of alpha-D-N-acetylglucosaminyl-2-O-sulfo-alpha-L-iduronic acid." [GOC:mengo_curators, PMID:19566715]
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides
created_by: gwg
creation_date: 2011-09-26T02:58:28Z

[Term]
id: GO:0052810
name: 1-phosphatidylinositol-5-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 5-phosphate + ADP + 2 H(+)." [EC:2.7.1.137]
synonym: "1-phosphatidylinositol 5-kinase activity" EXACT []
synonym: "ATP:1-phosphatidyl-1D-myo-inositol 5-phosphotransferase activity" EXACT [EC:2.7.1.137]
xref: EC:2.7.1.-
is_a: GO:0052742 ! phosphatidylinositol kinase activity
created_by: gwg
creation_date: 2011-10-21T03:37:20Z

[Term]
id: GO:0052811
name: 1-phosphatidylinositol-3-phosphate 4-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.150]
synonym: "ATP:1-phosphatidyl-1D-myo-inositol-3-phosphate 4-phosphotransferase activity" EXACT [EC:2.7.1.150]
synonym: "phosphatidylinositol 3-phosphate 4-kinase activity" EXACT [EC:2.7.1.150]
xref: EC:2.7.1.-
is_a: GO:0016307 ! phosphatidylinositol phosphate kinase activity
created_by: gwg
creation_date: 2011-10-21T03:47:58Z

[Term]
id: GO:0052812
name: phosphatidylinositol-3,4-bisphosphate 5-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H(+)." [EC:2.7.1.153]
synonym: "ATP:1-phosphatidyl-1D-myo-inositol-3,4-bisphosphate 5-phosphotransferase activity" EXACT [EC:2.7.1.153]
xref: EC:2.7.1.-
is_a: GO:0052813 ! phosphatidylinositol bisphosphate kinase activity
created_by: gwg
creation_date: 2011-10-21T03:52:02Z

[Term]
id: GO:0052813
name: phosphatidylinositol bisphosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + a phosphatidylinositol bisphosphate = ADP + a phosphatidylinositol trisphosphate." [GOC:ai]
xref: EC:2.7.1.-
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
relationship: part_of GO:0046854 ! phosphatidylinositol phosphorylation
created_by: gwg
creation_date: 2011-10-21T03:55:36Z

[Term]
id: GO:0052814
name: medium-chain-aldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a medium-chain aldehyde + NAD+ = a medium-chain carboxylate + NADH + H+. Medium-chain aldehydes have a chain length of between 8 and 12 carbons." [EC:1.2.1.48]
synonym: "medium-chain aliphatic aldehyde dehydrogenase activity" EXACT [EC:1.2.1.48]
synonym: "medium-chain fatty aldehyde dehydrogenase activity" EXACT [EC:1.2.1.48]
synonym: "medium-chain-aldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.48]
xref: EC:1.2.1.-
is_a: GO:0004029 ! aldehyde dehydrogenase (NAD) activity
creation_date: 2011-10-25T03:04:41Z

[Term]
id: GO:0052815
name: medium-chain acyl-CoA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + a medium-chain acyl-CoA = a medium-chain carboxylate + CoA. A medium chain is a chain of between eight and twelve carbons in length." [EC:3.1.2.19]
subset: gosubset_prok
synonym: "medium-chain acyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.19]
synonym: "medium-chain acyl-thioester hydrolase activity" EXACT [EC:3.1.2.19]
synonym: "medium-chain hydrolase activity" EXACT [EC:3.1.2.19]
synonym: "medium-chain-acyl-CoA hydrolase activity" EXACT [EC:3.1.2.19]
is_a: GO:0047617 ! acyl-CoA hydrolase activity
created_by: gwg
creation_date: 2011-10-25T05:26:29Z

[Term]
id: GO:0052816
name: long-chain acyl-CoA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + a long-chain acyl-CoA = a long-chain carboxylate + CoA. A long chain is a chain of greater than 12 carbons in length." [EC:3.1.2.19]
synonym: "long-chain acyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.19]
synonym: "long-chain acyl-thioester hydrolase activity" EXACT [EC:3.1.2.19]
synonym: "long-chain hydrolase activity" EXACT [EC:3.1.2.19]
synonym: "long-chain-acyl-CoA hydrolase activity" EXACT [EC:3.1.2.19]
is_a: GO:0047617 ! acyl-CoA hydrolase activity
created_by: gwg
creation_date: 2011-10-25T05:31:11Z

[Term]
id: GO:0052817
name: very long chain acyl-CoA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + a very long chain acyl-CoA = a very long chain carboxylate + CoA. A very long chain has chain length greater than C18." [EC:3.1.2.19]
synonym: "very long-chain acyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.19]
synonym: "very long-chain acyl-thioester hydrolase activity" EXACT [EC:3.1.2.19]
synonym: "very long-chain hydrolase activity" EXACT [EC:3.1.2.19]
synonym: "very long-chain-acyl-CoA hydrolase activity" EXACT [EC:3.1.2.19]
is_a: GO:0052816 ! long-chain acyl-CoA hydrolase activity
created_by: gwg
creation_date: 2011-10-27T12:18:28Z

[Term]
id: GO:0052818
name: heteroglycan 3-alpha-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: heteroglycan + GDP-mannose = (1->3)-alpha-D-mannosylheteroglycan + GDP." [EC:2.4.1.48, MetaCyc:RXN-7992]
synonym: "GDP mannose 3-alpha-mannosyltransferase activity" EXACT [EC:2.4.1.48]
synonym: "GDP-mannose:heteroglycan 3-alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.48]
synonym: "guanosine diphosphomannose-heteroglycan 3-alpha-mannosyltransferase activity" EXACT [EC:2.4.1.48]
synonym: "heteropolysaccharide 3-alpha-mannosyltransferase activity" EXACT [GOC:curators]
xref: EC:2.4.1.48
xref: KEGG:R03769
xref: MetaCyc:RXN-7992
is_a: GO:0047264 ! heteroglycan alpha-mannosyltransferase activity
created_by: gwg
creation_date: 2011-10-27T12:36:10Z

[Term]
id: GO:0052819
name: heteroglycan 2-alpha-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: heteroglycan + GDP-mannose = (1->2)-alpha-D-mannosylheteroglycan + GDP." [EC:2.4.1.48, MetaCyc:2.4.1.48-RXN]
synonym: "GDP mannose 2-alpha-mannosyltransferase activity" EXACT [EC:2.4.1.48]
synonym: "GDP-mannose:heteroglycan 2-alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.48]
synonym: "guanosine diphosphomannose-heteroglycan 2-alpha-mannosyltransferase activity" EXACT [EC:2.4.1.48]
synonym: "heteropolysaccharide 2-alpha-mannosyltransferase activity" EXACT [GOC:curators]
xref: EC:2.4.1.48
xref: KEGG:R03768
xref: MetaCyc:2.4.1.48-RXN
is_a: GO:0047264 ! heteroglycan alpha-mannosyltransferase activity
created_by: gwg
creation_date: 2011-10-27T12:36:19Z

[Term]
id: GO:0052820
name: DNA-1,N6-ethenoadenine N-glycosylase activity
namespace: molecular_function
def: "Catalysis of the reaction: DNA with 1-N6-ethenoadenine + H2O = DNA with abasic site + 1-N6-ethenoadenine. This reaction is the removal of 1,N6-ethenoadenine by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar." [PMID:21960007]
synonym: "1,N(6)-ethenoadenine N-glycosylase activity" EXACT []
synonym: "1,N6-ethenoadenine glycosylase activity" EXACT []
is_a: GO:0003905 ! alkylbase DNA N-glycosylase activity
creation_date: 2011-10-28T01:17:21Z

[Term]
id: GO:0052821
name: DNA-7-methyladenine glycosylase activity
namespace: molecular_function
def: "Catalysis of the reaction: DNA containing 7-methyladenine + H2O = DNA with abasic site + 7-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 7-methyladenine and the deoxyribose sugar to remove the 7-methyladenine, leaving an abasic site." [GOC:jl, PMID:16468998]
xref: EC:3.2.2.21
xref: MetaCyc:3.2.2.21-RXN
is_a: GO:0003905 ! alkylbase DNA N-glycosylase activity
created_by: gwg
creation_date: 2011-10-28T02:27:39Z

[Term]
id: GO:0052822
name: DNA-3-methylguanine glycosylase activity
namespace: molecular_function
def: "Catalysis of the reaction: DNA containing 3-methylguanine + H2O = DNA with abasic site + 3-methylguanine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methylguanine and the deoxyribose sugar to remove the 3-methylguanine, leaving an abasic site." [EC:3.2.2.21, GOC:elh, PMID:10872450, PMID:9224623]
synonym: "3-methylguanine DNA glycosylase I" RELATED [EC:3.2.2.20]
synonym: "alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)" BROAD [EC:3.2.2.20]
synonym: "deoxyribonucleate 3-methylguanine glycosidase I" RELATED [EC:3.2.2.20]
synonym: "DNA glycosidase I activity" RELATED [EC:3.2.2.20]
xref: EC:3.2.2.21
xref: MetaCyc:3.2.2.21-RXN
is_a: GO:0043733 ! DNA-3-methylbase glycosylase activity
created_by: gwg
creation_date: 2011-10-28T02:28:19Z

[Term]
id: GO:0052823
name: 2-hydroxy-6-oxonona-2,4,7-trienedioate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2E,4Z,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O = (2E)-2-hydroxypenta-2,4-dienoate + fumarate + H+." [RHEA:25049]
synonym: "(2E,4Z,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate fumarylhydrolase activity" EXACT systematic_synonym [EC:3.7.1.14]
synonym: "2-hydroxy-6-ketonona-2,4,7-trienedoic acid hydrolase activity" EXACT [UM-BBD_reactionID:r1622]
xref: EC:3.7.1.14
xref: MetaCyc:RXN-12070
xref: RHEA:25049
xref: UM-BBD_reactionID:r1622
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances
created_by: gwg
creation_date: 2011-10-28T03:28:37Z

[Term]
id: GO:0052824
name: dolichyl-pyrophosphate Man7GlcNAc2 alpha-1,6-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the addition of mannose to dolichyl-pyrophosphate Man7GlcNAc2 (also written as Man7GlcNAc2-PP-Dol) in alpha-(1->6) linkage, producing Man8GlcNAc2-PP-Dol." [PMID:10336995]
xref: EC:2.4.1.-
is_a: GO:0000009 ! alpha-1,6-mannosyltransferase activity
created_by: gwg
creation_date: 2011-10-28T03:57:17Z

[Term]
id: GO:0052825
name: inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: inositol-1,3,4,5,6-pentakisphosphate + H2O = inositol-3,4,5,6-tetrakisphosphate + phosphate." [GOC:ai]
xref: EC:3.1.3.-
is_a: GO:0052827 ! inositol pentakisphosphate phosphatase activity
creation_date: 2011-11-29T09:49:22Z

[Term]
id: GO:0052826
name: inositol hexakisphosphate 2-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = myo-inositol 1,3,4,5,6-pentakisphosphate + phosphate." [EC:3.1.3.62]
synonym: "1D-myo-inositol-hexakisphosphate 2-phosphohydrolase activity" EXACT [EC:3.1.3.62]
xref: EC:3.1.3.62
is_a: GO:0004446 ! inositol-hexakisphosphate phosphatase activity
created_by: gwg
creation_date: 2011-11-29T09:52:14Z

[Term]
id: GO:0052827
name: inositol pentakisphosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: myo-inositol pentakisphosphate + H2O = myo-inositol tetrakisphosphate + phosphate." [GOC:bf]
is_a: GO:0052745 ! inositol phosphate phosphatase activity
created_by: gwg
creation_date: 2011-11-29T09:55:04Z

[Term]
id: GO:0052828
name: inositol-3,4-bisphosphate 4-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol 3,4-bisphosphate + H2O = 1D-myo-inositol 3-phosphate + phosphate." [GOC:mah]
xref: EC:3.1.3.-
is_a: GO:0016312 ! inositol bisphosphate phosphatase activity
created_by: gwg
creation_date: 2011-11-29T09:57:00Z

[Term]
id: GO:0052829
name: inositol-1,3,4-trisphosphate 1-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-myo-inositol 1,3,4-trisphosphate + H2O = myo-inositol 3,4-bisphosphate + phosphate." [GOC:ai]
xref: EC:3.1.3.-
is_a: GO:0046030 ! inositol trisphosphate phosphatase activity
created_by: gwg
creation_date: 2011-11-29T09:58:00Z

[Term]
id: GO:0052830
name: inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: inositol-1,3,4,6-tetrakisphosphate + H2O = inositol-1,3,4-trisphosphate + phosphate." [GOC:ai]
xref: EC:3.1.3.-
is_a: GO:0052743 ! inositol tetrakisphosphate phosphatase activity
created_by: gwg
creation_date: 2011-11-29T10:56:59Z

[Term]
id: GO:0052831
name: inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: inositol-1,3,4,6-tetrakisphosphate + H2O = inositol-3,4,6-trisphosphate + phosphate." [GOC:ai]
xref: EC:3.1.3.-
is_a: GO:0052743 ! inositol tetrakisphosphate phosphatase activity
created_by: gwg
creation_date: 2011-11-29T10:58:27Z

[Term]
id: GO:0052832
name: inositol monophosphate 3-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: myo-inositol 3-phosphate + H2O = myo-inositol + phosphate." [EC:3.1.3.25]
xref: EC:3.1.3.25
xref: MetaCyc:MYO-INOSITOL-1OR-4-MONOPHOSPHATASE-RXN
is_a: GO:0052834 ! inositol monophosphate phosphatase activity
created_by: gwg
creation_date: 2011-11-29T11:00:09Z

[Term]
id: GO:0052833
name: inositol monophosphate 4-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: myo-inositol 4-phosphate + H2O = myo-inositol + phosphate." [EC:3.1.3.25]
synonym: "inositol-1(or 4)-monophosphatase activity" BROAD [EC:3.1.3.25]
synonym: "myo-inositol-1(or 4)-monophosphatase activity" BROAD []
synonym: "myo-inositol-1(or 4)-phosphate phosphohydrolase activity" BROAD []
xref: EC:3.1.3.25
xref: MetaCyc:RXN-10952
is_a: GO:0052834 ! inositol monophosphate phosphatase activity
created_by: gwg
creation_date: 2011-11-29T11:02:15Z

[Term]
id: GO:0052834
name: inositol monophosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: myo-inositol phosphate + H2O = myo-inositol + phosphate." [EC:3.1.3.25]
subset: gosubset_prok
synonym: "inositol phosphatase activity" EXACT [EC:3.1.3.25]
synonym: "inositol-1(or 4)-monophosphatase activity" BROAD [EC:3.1.3.25]
synonym: "inositol-phosphate phosphatase activity" EXACT [EC:3.1.3.25]
synonym: "L-myo-inositol-phosphate phosphatase activity" EXACT [EC:3.1.3.25]
synonym: "myo-inositol monophosphatase activity" EXACT [EC:3.1.3.25]
synonym: "myo-inositol phosphatase activity" EXACT [EC:3.1.3.25]
synonym: "myo-inositol-1(or 4)-phosphate phosphohydrolase activity" BROAD [EC:3.1.3.25]
synonym: "myo-inositol-phosphatase activity" EXACT [EC:3.1.3.25]
synonym: "myo-inositol-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.25]
xref: EC:3.1.3.25
xref: MetaCyc:RXN-10949
is_a: GO:0052745 ! inositol phosphate phosphatase activity
created_by: gwg
creation_date: 2011-11-29T11:15:58Z

[Term]
id: GO:0052835
name: inositol-3,4,6-trisphosphate 1-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol 3,4,6-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + 2 H(+)." [EC:2.7.1.134]
synonym: "1D-myo-inositol-trisphosphate 1-kinase activity" BROAD []
synonym: "ATP:1D-myo-inositol-3,4,6-trisphosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.127]
synonym: "inositol 3,4,6-trisphosphate 1-kinase activity" EXACT []
synonym: "inositol-trisphosphate 1-kinase activity" BROAD []
synonym: "ins(3,4,6)P(3) 1-kinase activity" EXACT [EC:2.7.1.127]
synonym: "Ins(3,4,6)P3 1-kinase activity" EXACT [EC:2.7.1.127]
synonym: "IP3 1-kinase activity" BROAD [EC:2.7.1.127]
xref: EC:2.7.1.-
is_a: GO:0051766 ! inositol trisphosphate kinase activity
created_by: gwg
creation_date: 2011-11-29T01:06:01Z

[Term]
id: GO:0052836
name: inositol 5-diphosphate pentakisphosphate 5-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + inositol 5-diphosphate pentakisphosphate = ADP + inositol 5-triphosphate pentakisphosphate." [PMID:11502751, PMID:18355727]
xref: EC:2.7.1.-
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
created_by: gwg
creation_date: 2011-11-29T01:14:22Z

[Term]
id: GO:0052837
name: thiazole biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a thiazole, a five-membered heterocyclic ring structure containing a sulfur in the 1-position and a nitrogen in the 3-position." [CHEBI:43732, GOC:curators]
subset: gosubset_prok
synonym: "thiazole anabolism" EXACT []
synonym: "thiazole biosynthesis" EXACT []
synonym: "thiazole formation" EXACT []
synonym: "thiazole synthesis" EXACT []
is_a: GO:0018131 ! oxazole or thiazole biosynthetic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:0052838 ! thiazole metabolic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process
created_by: gwg
creation_date: 2011-11-29T03:33:05Z

[Term]
id: GO:0052838
name: thiazole metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving oxazole or thiazole, five-membered heterocyclic ring structures containing an oxygen and a sulfur, respectively, in the 1-position and a nitrogen in the 3-position." [CHEBI:43732, GOC:curators]
subset: gosubset_prok
synonym: "thiazole metabolism" EXACT []
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0046484 ! oxazole or thiazole metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process
created_by: gwg
creation_date: 2011-11-29T03:35:50Z

[Term]
id: GO:0052839
name: inositol diphosphate tetrakisphosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: Catalysis of the reaction: ATP + inositol diphosphate tetrakisphosphate = ADP + inositol bisdiphosphate trisphosphate." [PMID:10827188, PMID:11502751, PMID:18355727]
xref: EC:2.7.1.-
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
created_by: gwg
creation_date: 2011-11-29T04:14:22Z

[Term]
id: GO:0052840
name: inositol diphosphate tetrakisphosphate diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: inositol diphosphate tetrakisphosphate + H2O = inositol 1,3,4,5,6-pentakisphosphate + phosphate." [MetaCyc:RXN-10963, PMID:10827188, PMID:11502751]
xref: EC:3.6.1.52
xref: MetaCyc:RXN-10963
is_a: GO:0016462 ! pyrophosphatase activity
created_by: gwg
creation_date: 2011-11-29T04:14:22Z

[Term]
id: GO:0052841
name: inositol bisdiphosphate tetrakisphosphate diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: inositol bisdiphosphate tetrakisphosphate + H2O = inositol diphosphate pentakisphosphate + phosphate." [MetaCyc:RXN-10965, MetaCyc:RXN-10975, MetaCyc:RXN-10976, PMID:10827188, PMID:11502751]
xref: EC:3.6.1.52
is_a: GO:0016462 ! pyrophosphatase activity
created_by: gwg
creation_date: 2011-11-29T04:14:22Z

[Term]
id: GO:0052842
name: inositol diphosphate pentakisphosphate diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: inositol diphosphate pentakisphosphate + H2O = inositol hexakisphosphate + phosphate." [MetaCyc:RXN-10964, MetaCyc:RXN-10977, MetaCyc:RXN-10978, PMID:10827188, PMID:11502751]
xref: EC:3.6.1.52
xref: KEGG:R05779
is_a: GO:0016462 ! pyrophosphatase activity
created_by: gwg
creation_date: 2011-11-29T04:14:22Z

[Term]
id: GO:0052843
name: inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate + H2O = inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + 2 H+." [MetaCyc:RXN-10977, PMID:10827188, PMID:11502751]
xref: EC:3.6.1.52
xref: MetaCyc:RXN-10977
is_a: GO:0052842 ! inositol diphosphate pentakisphosphate diphosphatase activity
created_by: gwg
creation_date: 2011-12-05T10:42:00Z

[Term]
id: GO:0052844
name: inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: inositol 3-diphosphate 1,2,4,5,6-pentakisphosphate + H2O = inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + 2 H+." [MetaCyc:RXN-10978, PMID:10827188, PMID:11502751]
xref: EC:3.6.1.52
xref: MetaCyc:RXN-10978
is_a: GO:0052842 ! inositol diphosphate pentakisphosphate diphosphatase activity
created_by: gwg
creation_date: 2011-12-05T10:59:26Z

[Term]
id: GO:0052845
name: inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate + H2O = inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + 2 H+." [MetaCyc:RXN-10964, PMID:10827188, PMID:11502751]
xref: EC:3.6.1.52
xref: MetaCyc:RXN-10964
is_a: GO:0052842 ! inositol diphosphate pentakisphosphate diphosphatase activity
created_by: gwg
creation_date: 2011-12-05T10:59:20Z

[Term]
id: GO:0052846
name: inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,5-bisdiphosphoinositol-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 1-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + phosphate + H+." [MetaCyc:RXN-10965, PMID:10827188, PMID:11502751]
xref: EC:3.6.1.52
xref: MetaCyc:RXN-10965
is_a: GO:0052841 ! inositol bisdiphosphate tetrakisphosphate diphosphatase activity
created_by: gwg
creation_date: 2011-12-05T11:02:23Z

[Term]
id: GO:0052847
name: inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,5-bisdiphosphoinositol-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + phosphate + H+." [MetaCyc:RXN-10975, PMID:10827188, PMID:11502751]
xref: EC:3.6.1.52
xref: MetaCyc:RXN-10975
is_a: GO:0052841 ! inositol bisdiphosphate tetrakisphosphate diphosphatase activity
created_by: gwg
creation_date: 2011-12-05T11:02:23Z

[Term]
id: GO:0052848
name: inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,5-bisdiphosphoinositol-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate + H+." [MetaCyc:RXN-10976, PMID:10827188, PMID:11502751]
xref: EC:3.6.1.52
xref: MetaCyc:RXN-10976
is_a: GO:0052841 ! inositol bisdiphosphate tetrakisphosphate diphosphatase activity
created_by: gwg
creation_date: 2011-12-05T11:02:23Z

[Term]
id: GO:0052849
name: NADPH-dependent curcumin reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: curcumin + NADPH + H+ = dihydrocurcumin + NADP+." [MetaCyc:RXN0-6676]
xref: EC:1.3.1.-
xref: MetaCyc:RXN0-6676
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
created_by: gwg
creation_date: 2011-12-05T11:03:23Z

[Term]
id: GO:0052850
name: NADPH-dependent dihydrocurcumin reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: dihydrocurcumin + NADPH+ + H+ = tetrahydrocurcumin + NADP+." [MetaCyc:RXN0-6677]
synonym: "dihydrocurcumin reductase (NADPH) activity" EXACT []
xref: EC:1.3.1.-
xref: MetaCyc:RXN0-6677
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
created_by: gwg
creation_date: 2011-12-05T11:04:23Z

[Term]
id: GO:0052851
name: ferric-chelate reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 Fe3+ + NADPH = 2 Fe2+ + H+ + NADP+ ." [MetaCyc:RXN0-6555]
synonym: "Fe(II):NADP+ oxidoreductase activity" EXACT []
synonym: "ferric chelate reductase activity" BROAD []
synonym: "ferric reductase, NADPH-dependent activity" EXACT []
synonym: "iron chelate reductase activity" BROAD []
synonym: "NADPH:Fe3+-EDTA reductase activity" EXACT []
xref: EC:1.16.1.9
xref: KEGG:R09541
xref: MetaCyc:RXN0-6555
xref: RHEA:28798
is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor
created_by: gwg
creation_date: 2011-12-05T11:04:23Z

[Term]
id: GO:0052852
name: very-long-chain-(S)-2-hydroxy-acid oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: very-long-chain (S)-2-hydroxy-acid + O2 = very-long-chain 2-oxo acid + hydrogen peroxide. Very long chain refers to a chain length of greater than 18 carbons." [EC:1.1.3.15]
subset: gosubset_prok
synonym: "oxidase, very-long-chain L-2-hydroxy acid" EXACT [EC:1.1.3.15]
synonym: "very-long-chain L-2-hydroxy acid oxidase" EXACT [EC:1.1.3.15]
synonym: "very-long-chain L-alpha-hydroxy acid oxidase" EXACT [EC:1.1.3.15]
synonym: "very-long-chain-(S)-2-hydroxy-acid:oxygen 2-oxidoreductase" EXACT [EC:1.1.3.15]
synonym: "very-long-chain-hydroxy-acid oxidase A activity" NARROW [EC:1.1.3.15]
synonym: "very-long-chain-hydroxy-acid oxidase B activity" NARROW [EC:1.1.3.15]
synonym: "very-long-chain-hydroxyacid oxidase A" RELATED [EC:1.1.3.15]
xref: EC:1.1.3.15
is_a: GO:0003973 ! (S)-2-hydroxy-acid oxidase activity
creation_date: 2011-12-05T12:55:03Z

[Term]
id: GO:0052853
name: long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: long-chain-(S)-2-hydroxy-acid + O2 = long-chain-2-oxo acid + hydrogen peroxide. Long chain refers to a chain length of 14 to 18 carbons." [EC:1.1.3.15]
subset: gosubset_prok
synonym: "long-chain-(S)-2-hydroxy-acid:oxygen 2-oxidoreductase" EXACT [EC:1.1.3.15]
synonym: "long-chain-hydroxy-acid oxidase A activity" NARROW [EC:1.1.3.15]
synonym: "long-chain-hydroxy-acid oxidase B activity" NARROW [EC:1.1.3.15]
synonym: "long-chain-hydroxyacid oxidase A" RELATED [EC:1.1.3.15]
synonym: "long-chain-L-2-hydroxy acid oxidase" EXACT [EC:1.1.3.15]
synonym: "long-chain-L-alpha-hydroxy acid oxidase" EXACT [EC:1.1.3.15]
synonym: "oxidase, long-chain-L-2-hydroxy acid" EXACT [EC:1.1.3.15]
xref: EC:1.1.3.15
is_a: GO:0003973 ! (S)-2-hydroxy-acid oxidase activity
creation_date: 2011-12-05T12:55:03Z

[Term]
id: GO:0052854
name: medium-chain-(S)-2-hydroxy-acid oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: medium-chain-(S)-2-hydroxy-acid + O2 = medium-chain-2-oxo acid + hydrogen peroxide. Medium chain refers to a chain length of between 8 and 12 carbons." [EC:1.1.3.15]
subset: gosubset_prok
synonym: "medium-chain-(S)-2-hydroxy-acid:oxygen 2-oxidoreductase" EXACT [EC:1.1.3.15]
synonym: "medium-chain-hydroxy-acid oxidase A activity" NARROW [EC:1.1.3.15]
synonym: "medium-chain-hydroxy-acid oxidase B activity" NARROW [EC:1.1.3.15]
synonym: "medium-chain-hydroxyacid oxidase A" RELATED [EC:1.1.3.15]
synonym: "medium-chain-L-2-hydroxy acid oxidase" EXACT [EC:1.1.3.15]
synonym: "medium-chain-L-alpha-hydroxy acid oxidase" EXACT [EC:1.1.3.15]
synonym: "oxidase, medium-chain-L-2-hydroxy acid" EXACT [EC:1.1.3.15]
xref: EC:1.1.3.15
is_a: GO:0003973 ! (S)-2-hydroxy-acid oxidase activity
creation_date: 2011-12-05T12:55:03Z

[Term]
id: GO:0052855
name: ADP-dependent NAD(P)H-hydrate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine dinucleotide + ADP = AMP + 3 H(+) + NADH + phosphate." [EC:4.2.1.93, PMID:21994945]
synonym: "(6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ADP-hydrolysing)" EXACT [EC:4.2.1.93]
synonym: "(6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase(ADP-hydrolysing; NADH-forming)" RELATED [EC:4.2.1.93]
synonym: "ADP-dependent H(4)NAD(P)OH dehydratase activity" EXACT []
synonym: "ADP-dependent H4NAD(P)OH dehydratase activity" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide hydrate dehydratase activity" BROAD [EC:4.2.1.93]
xref: EC:4.2.1.-
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0052856
name: NADHX epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-NADHX = (S)-NADHX." [PMID:21994945]
xref: EC:5.1.-.-
is_a: GO:0016854 ! racemase and epimerase activity

[Term]
id: GO:0052857
name: NADPHX epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-NADPHX = (S)-NADPHX." [PMID:21994945]
xref: EC:5.1.-.-
is_a: GO:0016854 ! racemase and epimerase activity

[Term]
id: GO:0052858
name: peptidyl-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor
namespace: molecular_function
def: "Catalysis of the reaction: acetyl phosphate + peptidyl-L-lysine = phosphate + peptidyl-N6-acetyl-L-lysine." [GOC:tb]
synonym: "acetyl-phosphate:peptidyl-L-lysine 6-N-acetyltransferase activity" EXACT []
synonym: "acetyl-phosphate:peptidyl-L-lysine N6-acetyltransferase activity" EXACT []
synonym: "peptidyl-lysine acetyltransferase activity" EXACT []
synonym: "peptidyl-lysine N(6)-acetyltransferase activity" EXACT []
synonym: "peptidyl-lysine N6-acetyltransferase activity" EXACT []
xref: EC:2.3.1.-
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0052859
name: glucan endo-1,4-beta-glucosidase activity
namespace: molecular_function
def: "Catalysis of the random hydrolysis of (1->4) linkages in (1->4)-beta-D-glucans." [EC:3.2.1.75]
synonym: "1,4-beta-D-glucan glucanohydrolase activity" EXACT []
synonym: "beta-1,4-glucan 4-glucanohydrolase activity" EXACT []
synonym: "beta-1,4-glucan hydrolase activity" EXACT []
synonym: "beta-1,4-glucanase activity" EXACT []
synonym: "beta-1->4-glucan hydrolase activity" EXACT []
synonym: "endo-(1,4)-beta-D-glucanase activity" EXACT []
synonym: "endo-(1->4)-beta-D-glucanase activity" EXACT []
synonym: "endo-1,4-beta-D-glucanase activity" EXACT []
synonym: "endo-1,4-beta-glucanase activity" EXACT []
synonym: "endo-beta-1,4-glucanase activity" EXACT []
xref: EC:3.2.1.-
is_a: GO:0008422 ! beta-glucosidase activity
created_by: gwg
creation_date: 2011-12-06T03:48:44Z

[Term]
id: GO:0052860
name: 2'-deoxymugineic-acid 3-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2'-deoxymugineic acid + 2-oxoglutarate + O2 = 3-epihydroxy-2'-deoxymugineic acid + succinate + CO2." [EC:1.14.11.25]
synonym: "2'-deoxymugineic acid,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.11.25]
xref: EC:1.14.11.25
xref: KEGG:R07187
xref: MetaCyc:RXN-7983
xref: RHEA:20068
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
created_by: gwg
creation_date: 2011-12-05T06:00:58Z

[Term]
id: GO:0052861
name: glucan endo-1,3-beta-glucanase activity, C-3 substituted reducing group
namespace: molecular_function
def: "Catalysis of the endohydrolysis of (1->3)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolysed is itself substituted at C-3." [EC:3.2.1.6]
synonym: "1,3-(1,3)-beta-D-glucan 3-glucanohydrolase activity" EXACT [EC:3.2.1.6]
synonym: "laminaranase activity" RELATED [EC:3.2.1.6]
synonym: "laminarinase activity" RELATED [EC:3.2.1.6]
xref: EC:3.2.1.6
xref: MetaCyc:3.2.1.6-RXN
is_a: GO:0052736 ! beta-glucanase activity
created_by: gwg
creation_date: 2011-12-06T04:49:36Z

[Term]
id: GO:0052862
name: glucan endo-1,4-beta-glucanase activity, C-3 substituted reducing group
namespace: molecular_function
def: "Catalysis of the endohydrolysis of (1->4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolysed is itself substituted at C-3." [EC:3.2.1.6]
synonym: "1,3-(1,4)-beta-D-glucan 4-glucanohydrolase activity" EXACT [EC:3.2.1.6]
synonym: "laminaranase activity" RELATED [EC:3.2.1.6]
synonym: "laminarinase activity" RELATED [EC:3.2.1.6]
xref: EC:3.2.1.6
xref: MetaCyc:3.2.1.6-RXN
is_a: GO:0052736 ! beta-glucanase activity
created_by: gwg
creation_date: 2011-12-06T05:27:26Z

[Term]
id: GO:0052863
name: 1-deoxy-D-xylulose 5-phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 1-deoxy-D-xylulose 5-phosphate, the 5-phospho derivative of 1-deoxy-D-xylulose. 1-deoxy-D-xylulose 5-phosphate is an intermediate in the non-mevalonate pathway and a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis." [CHEBI:16493, KEGG:C11437, PubChem:13609]
synonym: "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate metabolic process" EXACT []
synonym: "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate metabolism" EXACT []
synonym: "1-deoxy-D-xylulose 5-phosphate metabolism" EXACT []
xref: KEGG:ko00730 "Thiamine metabolism"
xref: KEGG:ko00900 "Terpenoid backbone biosynthesis"
xref: KEGG:ko01100 "Metabolic pathways"
xref: KEGG:ko01110 "Biosynthesis of secondary metabolites"
xref: KEGG:map01060 "Biosynthesis of plant secondary metabolites"
xref: KEGG:map01062 "Biosynthesis of terpenoids and steroids"
xref: KEGG:map01066 "Biosynthesis of alkaloids derived from terpenoid and polyketide"
xref: KEGG:map01070 "Biosynthesis of plant hormones"
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process

[Term]
id: GO:0052864
name: 1-deoxy-D-xylulose 5-phosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 1-deoxy-D-xylulose 5-phosphate, the 5-phospho derivative of 1-deoxy-D-xylulose. 1-deoxy-D-xylulose 5-phosphate is an intermediate in the non-mevalonate pathway and a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis." [CHEBI:16493, KEGG:C11437, PubChem:13609]
synonym: "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate breakdown" EXACT []
synonym: "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate catabolic process" EXACT []
synonym: "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate catabolism" EXACT []
synonym: "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate degradation" EXACT []
synonym: "1-deoxy-D-xylulose 5-phosphate breakdown" EXACT []
synonym: "1-deoxy-D-xylulose 5-phosphate catabolism" EXACT []
synonym: "1-deoxy-D-xylulose 5-phosphate degradation" EXACT []
is_a: GO:0046434 ! organophosphate catabolic process
is_a: GO:0052863 ! 1-deoxy-D-xylulose 5-phosphate metabolic process
is_a: GO:1901136 ! carbohydrate derivative catabolic process

[Term]
id: GO:0052865
name: 1-deoxy-D-xylulose 5-phosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 1-deoxy-D-xylulose 5-phosphate, the 5-phospho derivative of 1-deoxy-D-xylulose. 1-deoxy-D-xylulose 5-phosphate is an intermediate in the non-mevalonate pathway and a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis." [CHEBI:16493, KEGG:C11437, PubChem:13609]
synonym: "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate anabolism" EXACT []
synonym: "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate biosynthesis" EXACT []
synonym: "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate biosynthetic process" EXACT []
synonym: "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate formation" EXACT []
synonym: "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate synthesis" EXACT []
synonym: "1-deoxy-D-xylulose 5-phosphate anabolism" EXACT []
synonym: "1-deoxy-D-xylulose 5-phosphate biosynthesis" EXACT []
synonym: "1-deoxy-D-xylulose 5-phosphate formation" EXACT []
synonym: "1-deoxy-D-xylulose 5-phosphate synthesis" EXACT []
xref: UniPathway:UPA00064
is_a: GO:0052863 ! 1-deoxy-D-xylulose 5-phosphate metabolic process
is_a: GO:0090407 ! organophosphate biosynthetic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process

[Term]
id: GO:0052866
name: phosphatidylinositol phosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphatidylinositol phosphate(n) + H2O = phosphatidylinositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from a phosphatidylinositol phosphate." [GOC:ai]
subset: gosubset_prok
synonym: "phosphoinositide phosphatase activity" EXACT []
is_a: GO:0016791 ! phosphatase activity
created_by: gwg
creation_date: 2011-12-13T01:20:17Z

[Term]
id: GO:0052867
name: phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphatidyl-1D-myo-inositol 1,4,5-trisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 1,4-bisphosphate + phosphate." [EC:3.1.3.-]
synonym: "phosphatidyl-myo-inositol-1,4,5-trisphosphate phosphatase activity" BROAD [EC:3.1.3.-]
synonym: "phosphatidylinositol 1,4,5-trisphosphate phosphatase activity" BROAD [EC:3.1.3.-]
synonym: "phosphatidylinositol-trisphosphatase activity" BROAD [EC:3.1.3.-]
synonym: "PtdIns(1,4,5)P(3) phosphatase activity" BROAD [EC:3.1.3.-]
synonym: "PtdIns(1,4,5)P3 phosphatase activity" BROAD [EC:3.1.3.-]
synonym: "triphosphoinositide phosphatase activity" BROAD [EC:3.1.3.-]
synonym: "triphosphoinositide phosphomonoesterase activity" BROAD [EC:3.1.3.-]
xref: EC:3.1.3.-
is_a: GO:0034594 ! phosphatidylinositol trisphosphate phosphatase activity
is_a: GO:0034595 ! phosphatidylinositol phosphate 5-phosphatase activity
creation_date: 2012-01-11T12:07:50Z

[Term]
id: GO:0052868
name: protein-lysine lysyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein-lysine + protein-lysine = protein N6-(lysyl)-L-lysine + protein. This reaction is the addition of lysine group from one protein to a lysine residue in a second protein, producing N6-(lysyl)-L-lysine." [PMID:20729861]
is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups
created_by: gwg
creation_date: 2012-01-11T03:05:27Z

[Term]
id: GO:0052869
name: arachidonic acid omega-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: arachidonic acid + O2 + NADPH + H+ = 20-HETE + NADP+ + H2O. Arachidonic acid is also known as (5Z,8Z,11Z,14Z)-icosatetraenoic acid, and 20-HETE is also known as (5Z,8Z,11Z,14Z)-20-hydroxyicosa-5,8,11,14-tetraenoic acid." [KEGG:R07041]
synonym: "arachidonic acid hydroxylase activity" BROAD []
synonym: "arachidonic acid:oxygen 1-oxidoreductase activity" EXACT systematic_synonym []
xref: EC:1.14.15.3
xref: KEGG:R07041
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
created_by: gwg
creation_date: 2012-01-30T03:05:27Z

[Term]
id: GO:0052870
name: tocopherol omega-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: tocopherol + O2 + NADPH + H+ = 13'-hydroxy-tocopherol + NADP+ + H2O ." [MetaCyc:RXN-11003]
synonym: "tocopherol 13-hydroxylase activity" EXACT systematic_synonym []
xref: EC:1.14.13.30
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
created_by: gwg
creation_date: 2012-01-30T03:06:27Z

[Term]
id: GO:0052871
name: alpha-tocopherol omega-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-tocopherol + O2 + NADPH + H+ = 13'-hydroxy-alpha-tocopherol + NADP+ + H2O ." [MetaCyc:RXN-11003]
synonym: "alpha-tocopherol 13-hydroxylase activity" EXACT []
xref: EC:1.14.13.30
xref: MetaCyc:RXN-11003
is_a: GO:0052870 ! tocopherol omega-hydroxylase activity
created_by: gwg
creation_date: 2012-01-30T03:06:27Z

[Term]
id: GO:0052872
name: tocotrienol omega-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: tocotrienol + O2 + NADPH + H+ = 13'-hydroxy-tocotrienol + NADP+ + H2O ." [MetaCyc:RXN-11003]
synonym: "tocotrienol 13-hydroxylase activity" EXACT []
xref: EC:1.14.13.-
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
created_by: gwg
creation_date: 2012-01-30T03:07:27Z

[Term]
id: GO:0052873
name: FMN reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: FMNH2 + NADP+ = FMN + NADPH + 2 H+." [RHEA:21627]
subset: gosubset_prok
synonym: "flavin mononucleotide reductase activity" BROAD [EC:1.5.1.29]
synonym: "flavine mononucleotide reductase activity" BROAD [EC:1.5.1.29]
synonym: "FMNH2:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.29]
synonym: "NADPH dehydrogenase (FMN) activity" EXACT []
synonym: "NADPH(2) dehydrogenase (FMN) activity" EXACT [EC:1.5.1.29]
synonym: "NADPH(2):FMN oxidoreductase activity" EXACT [EC:1.5.1.29]
synonym: "NADPH-dependent FMN reductase activity" EXACT [EC:1.5.1.29]
synonym: "NADPH-FMN reductase activity" EXACT [EC:1.5.1.29]
synonym: "NADPH2 dehydrogenase (FMN)" EXACT [EC:1.5.1.3]
synonym: "NADPH2:FMN oxidoreductase activity" EXACT [EC:1.5.1.29]
synonym: "NADPH:flavin oxidoreductase activity" EXACT [EC:1.5.1.29]
synonym: "NADPH:FMN oxidoreductase activity" EXACT [EC:1.5.1.29]
synonym: "SsuE" RELATED [EC:1.5.1.29]
xref: EC:1.5.1.38
xref: EC:1.5.1.39
xref: KEGG:R05706
xref: RHEA:21627
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0052874
name: FMN reductase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: FMNH2 + NAD+ = FMN + NADH + 2 H+." [RHEA:21623]
subset: gosubset_prok
synonym: "flavin mononucleotide reductase activity" BROAD [EC:1.5.1.29]
synonym: "flavine mononucleotide reductase activity" BROAD [EC:1.5.1.29]
synonym: "FMNH2:NAD+ oxidoreductase activity" EXACT [EC:1.5.1.29]
synonym: "NADH dehydrogenase (FMN) activity" EXACT []
synonym: "NADH(2) dehydrogenase (FMN) activity" EXACT [EC:1.5.1.29]
synonym: "NADH(2):FMN oxidoreductase activity" EXACT [EC:1.5.1.29]
synonym: "NADH-dependent FMN reductase activity" EXACT [EC:1.5.1.29]
synonym: "NADH-FMN reductase activity" EXACT [EC:1.5.1.29]
synonym: "NADH2 dehydrogenase (FMN)" EXACT [EC:1.5.1.3]
synonym: "NADH2:FMN oxidoreductase activity" EXACT [EC:1.5.1.29]
synonym: "NADH:flavin oxidoreductase activity" EXACT [EC:1.5.1.29]
synonym: "NADH:FMN oxidoreductase activity" EXACT [EC:1.5.1.29]
synonym: "SsuE" RELATED [EC:1.5.1.29]
xref: EC:1.5.1.39
xref: KEGG:R05705
xref: RHEA:21623
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0052875
name: riboflavin reductase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: reduced riboflavin + NAD+ = riboflavin + NADH + 2 H+." [RHEA:31458]
synonym: "flavin mononucleotide reductase activity" RELATED [EC:1.5.1.41]
synonym: "flavine mononucleotide reductase activity" RELATED [EC:1.5.1.41]
synonym: "NAD(P)H-dependent FMN reductase activity" RELATED [EC:1.5.1.41]
synonym: "NAD(P)H-FMN reductase activity" RELATED [EC:1.5.1.41]
synonym: "NAD(P)H2 dehydrogenase (FMN) activity" RELATED [EC:1.5.1.41]
synonym: "NAD(P)H2:FMN oxidoreductase activity" RELATED [EC:1.5.1.41]
synonym: "NAD(P)H:FMN oxidoreductase activity" RELATED [EC:1.5.1.41]
synonym: "NAD(P)H:riboflavin oxidoreductase activity" EXACT [EC:1.5.1.41]
synonym: "riboflavin mononucleotide (reduced nicotinamide adenine dinucleotide) reductase activity" EXACT [EC:1.5.1.41]
synonym: "riboflavin mononucleotide reductase activity" RELATED [EC:1.5.1.41]
synonym: "riboflavine mononucleotide reductase activity" RELATED [EC:1.5.1.41]
xref: EC:1.5.1.41
xref: KEGG:R09750
xref: MetaCyc:RXN-12445
xref: RHEA:31458
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0052876
name: methylamine dehydrogenase (amicyanin) activity
namespace: molecular_function
def: "Catalysis of the reaction: methylamine + H2O + amicyanin = formaldehyde + ammonia + reduced amicyanin." [KEGG:R00606]
synonym: "amine dehydrogenase activity" BROAD [EC:1.4.9.1]
synonym: "amine:(acceptor) oxidoreductase (deaminating) activity" BROAD [EC:1.4.9.1]
synonym: "MADH activity" BROAD [EC:1.4.9.1]
synonym: "methylamine dehydrogenase activity" BROAD [EC:1.4.9.1]
synonym: "methylamine:amicyanin oxidoreductase (deaminating) activity" EXACT systematic_synonym [EC:1.4.9.1]
synonym: "primary-amine dehydrogenase activity" BROAD [EC:1.4.9.1]
synonym: "primary-amine:(acceptor) oxidoreductase (deaminating) activity" BROAD [EC:1.4.9.1]
xref: EC:1.4.9.1
xref: KEGG:R00606
xref: UM-BBD_reactionID:r0075
is_a: GO:0052877 ! oxidoreductase activity, acting on the CH-NH2 group of donors, with a copper protein as acceptor

[Term]
id: GO:0052877
name: oxidoreductase activity, acting on the CH-NH2 group of donors, with a copper protein as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and a copper protein is the acceptor." [GOC:ai]
subset: gosubset_prok
xref: EC:1.4.9
is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors

[Term]
id: GO:0052878
name: linoleate 8R-lipoxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: O(2) + linoleate = (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate." [RHEA:25398]
synonym: "5,8-LDS (bifunctional enzyme) activity" RELATED [EC:1.13.11.60]
synonym: "5,8-linoleate diol synthase (bifunctional enzyme) activity" RELATED [EC:1.13.11.60]
synonym: "7,8-LDS (bifunctional enzyme) activity" RELATED [EC:1.13.11.60]
synonym: "7,8-linoleate diol synthase (bifunctional enzyme) activity" RELATED [EC:1.13.11.60]
synonym: "linoleate diol synthase activity" RELATED [EC:1.13.11.44]
xref: EC:1.13.11.60
xref: KEGG:R07061
xref: MetaCyc:1.13.11.44-RXN
xref: RHEA:25398 "O(2) + linoleate = (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate"
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0052879
name: 9,12-octadecadienoate 8-hydroperoxide 8S-isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate = (7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate." [RHEA:25402]
synonym: "(8R,9Z,12Z)-8-hydroperoxy-9,12-octadecadienoate mutase ((7S,8S,9Z,12Z)-5,8-dihydroxy-9,12-octadecadienoate-forming) activity" EXACT [EC:5.4.4.6]
synonym: "8-hydroperoxide isomerase activity" BROAD [EC:5.4.4.6]
synonym: "linoleate diol synthase activity" RELATED [EC:1.13.11.44]
xref: EC:5.4.4.6
xref: KEGG:R07062
xref: MetaCyc:1.13.11.44-RXN
xref: RHEA:25402 "(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate = (7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate"
is_a: GO:0050486 ! intramolecular transferase activity, transferring hydroxy groups

[Term]
id: GO:0052880
name: oxidoreductase activity, acting on diphenols and related substances as donors, with copper protein as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces a copper protein." [GOC:jl]
xref: EC:1.10.9
is_a: GO:0016679 ! oxidoreductase activity, acting on diphenols and related substances as donors

[Term]
id: GO:0052881
name: 4-hydroxyphenylacetate 3-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (4-hydroxyphenyl)acetate + FADH(2) + O(2) = 3,4-dihydroxyphenylacetate + FAD + H(+) + H(2)O." [RHEA:30598]
synonym: "4 HPA 3-hydroxylase activity" BROAD [EC:1.14.14.9]
synonym: "4-hydroxyphenylacetate,FADH:oxygen oxidoreductase (3-hydroxylating) activity" EXACT systematic_synonym []
synonym: "4-hydroxyphenylacetic acid-3-hydroxylase activity" BROAD [EC:1.14.14.9]
synonym: "p-hydroxyphenylacetate 3-hydroxylase (FAD) activity" EXACT [EC:1.14.14.9]
synonym: "p-hydroxyphenylacetate 3-hydroxylase activity" BROAD [EC:1.14.14.9]
synonym: "p-hydroxyphenylacetate hydroxylase (FAD) activity" EXACT [EC:1.14.14.9]
synonym: "p-hydroxyphenylacetate hydroxylase activity" BROAD [EC:1.14.14.9]
xref: EC:1.14.14.9
xref: MetaCyc:RXN-8505
xref: RHEA:30598 "(4-hydroxyphenyl)acetate + FADH(2) + O(2) = 3,4-dihydroxyphenylacetate + FAD + H(+) + H(2)O"
xref: UM-BBD_reactionID:r0301
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0052882
name: oxidoreductase activity, acting on phosphorus or arsenic in donors, with a copper protein as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a copper protein." [GOC:jl]
xref: EC:1.20.9
is_a: GO:0030613 ! oxidoreductase activity, acting on phosphorus or arsenic in donors

[Term]
id: GO:0052883
name: tyrosine ammonia-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tyrosine = NH(4)(+) + trans-4-coumarate." [RHEA:24909]
synonym: "L-tyrosine ammonia-lyase activity" EXACT [EC:4.3.1.23]
synonym: "TAL activity" BROAD [EC:4.3.1.23]
synonym: "tyrase activity" BROAD [EC:4.3.1.23]
xref: EC:4.3.1.23
xref: EC:4.3.1.25
xref: RHEA:24909 "L-tyrosine = NH(4)(+) + trans-4-coumarate"
is_a: GO:0016841 ! ammonia-lyase activity

[Term]
id: GO:0052884
name: all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + all-trans-retinyl palmitate = 11-cis-retinol + H(+) + palmitate." [RHEA:31778]
synonym: "all-trans-retinol isomerase:hydrolase activity" BROAD [EC:3.1.1.64]
synonym: "all-trans-retinyl-palmitate hydrolase activity" BROAD [EC:3.1.1.64]
synonym: "retinoid isomerohydrolase activity" BROAD [EC:3.1.1.64]
synonym: "retinol isomerase activity" BROAD [EC:3.1.1.64]
xref: EC:3.1.1.64
xref: RHEA:31778 "H(2)O + all-trans-retinyl palmitate = 11-cis-retinol + H(+) + palmitate"
is_a: GO:0052689 ! carboxylic ester hydrolase activity
relationship: part_of GO:0042572 ! retinol metabolic process

[Term]
id: GO:0052885
name: all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + all-trans-retinyl ester = 11-cis-retinol + fatty acid." [RHEA:31774]
synonym: "all-trans-retinol isomerase:hydrolase activity" BROAD [EC:3.1.1.64]
synonym: "all-trans-retinyl ester acylhydrolase, 11-cis retinol forming activity" EXACT [EC:3.1.1.64]
synonym: "all-trans-retinylester 11-cis isomerohydrolase activity" EXACT [EC:3.1.1.64]
synonym: "retinoid isomerohydrolase activity" BROAD [EC:3.1.1.64]
synonym: "retinol isomerase activity" BROAD [EC:3.1.1.64]
xref: EC:3.1.1.64
xref: KEGG:R08388
xref: MetaCyc:RXN-12550
xref: RHEA:31774 "H(2)O + all-trans-retinyl ester = 11-cis-retinol + fatty acid"
is_a: GO:0052689 ! carboxylic ester hydrolase activity
relationship: part_of GO:0042572 ! retinol metabolic process

[Term]
id: GO:0052886
name: 9,9'-dicis-carotene:quinone oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 9,9'-di-cis-zeta-carotene + a quinone = 7,9,9'-tri-cis-neurosporene + a quinol." [EC:1.3.5.6]
synonym: "9,9'-di-cis-zeta-carotene desaturase activity" BROAD [EC:1.3.5.6]
synonym: "ZDS activity" BROAD [EC:1.3.5.6]
synonym: "zeta-carotene desaturase activity" BROAD [EC:1.3.5.6]
xref: EC:1.3.5.6
xref: KEGG:R09656
xref: MetaCyc:RXN-11356
is_a: GO:0016635 ! oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor

[Term]
id: GO:0052887
name: 7,9,9'-tricis-neurosporene:quinone oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7,9,9'-tri-cis-neurosporene + a quinone = 7,9,7',9'-tetra-cis-lycopene + a quinol." [EC:1.3.5.6]
synonym: "9,9'-di-cis-zeta-carotene desaturase activity" BROAD [EC:1.3.5.6]
synonym: "ZDS activity" BROAD [EC:1.3.5.6]
synonym: "zeta-carotene desaturase activity" BROAD [EC:1.3.5.6]
xref: EC:1.3.5.6
xref: KEGG:R09658
xref: MetaCyc:RXN-11357
is_a: GO:0016635 ! oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor

[Term]
id: GO:0052888
name: obsolete OBSOLETE:dihydroorotate oxidase (fumarate) activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-dihydroorotate + fumarate = orotate + succinate." [EC:1.3.98.1, RHEA:30062]
comment: EC has determined that this reaction in fact does not exist. They have withdrawn EC 1.3.3.1.Note: If fumarate is not shown to be nvolved, you may want to consider GO:0004152, dihydroorotate dehydrogenase activity (parent term); if the reaction involves fumarate, then use GO:0052888 dihydroorotate oxidase (fumarate) activity See SF 10770 for details. http://sourceforge.net/p/geneontology/ontology-requests/10770/
synonym: "DHOD activity" BROAD [EC:1.3.98.1]
synonym: "DHOdase activity" BROAD [EC:1.3.98.1]
synonym: "DHodehase activity" BROAD [EC:1.3.98.1]
synonym: "dihydoorotic acid dehydrogenase activity" BROAD [EC:1.3.98.1]
synonym: "dihydroorotate dehydrogenase activity" BROAD [EC:1.3.98.1]
synonym: "dihydroorotate oxidase activity" BROAD [EC:1.3.98.1]
synonym: "OBSOLETE:dihydroorotate oxidase (fumarate) activity" EXACT []
xref: EC:1.3.98.1
xref: KEGG:R01867
xref: MetaCyc:RXN-9929
xref: RHEA:30062 "(S)-dihydroorotate + fumarate = orotate + succinate"
is_obsolete: true

[Term]
id: GO:0052889
name: 9,9'-di-cis-zeta-carotene desaturation to 7,9,7',9'-tetra-cis-lycopene
namespace: biological_process
def: "The series of reactions in which 9,9'-di-cis-zeta-carotene is desaturated to 7,9,9'-tri-cis-neurosporene, and then 7,9,7',9'-tetra-cis-lycopene. The overall reaction for this process is: 9,9'-di-cis-zeta-carotene + 2 quinone = 2 quinol + 7,9,7',9'-tetra-cis-lycopene." [EC:1.3.5.6, KEGG:R07511]
synonym: "7,9,7',9'-tetra-cis-lycopene biosynthesis from 9,9'-di-cis-zeta-carotene" EXACT []
synonym: "9,9'-di-cis-zeta-carotene catabolism to 7,9,7',9'-tetra-cis-lycopene" EXACT []
synonym: "9,9'-di-cis-zeta-carotene desaturase activity" EXACT [EC:1.3.5.6]
synonym: "9,9'-dicis-zeta-carotene:quinone oxidoreductase activity" EXACT [KEGG:R07511]
synonym: "ZDS activity" BROAD [EC:1.3.5.6]
synonym: "zeta-carotene desaturase activity" BROAD [EC:1.3.5.6]
xref: EC:1.3.5.6
xref: KEGG:R07511
xref: MetaCyc:RXN-12242
is_a: GO:0016119 ! carotene metabolic process
relationship: has_part GO:0052886 ! 9,9'-dicis-carotene:quinone oxidoreductase activity
relationship: has_part GO:0052887 ! 7,9,9'-tricis-neurosporene:quinone oxidoreductase activity

[Term]
id: GO:0052890
name: oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a flavin." [GOC:jl]
subset: gosubset_prok
xref: EC:1.3.8
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0052891
name: aliphatic (S)-hydroxynitrile lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: an aliphatic (S)-hydroxynitrile = an aliphatic aldehyde or ketone + cyanide." [EC:4.1.2.47]
synonym: "(S)-cyanohydrin carbonyl-lyase (cyanide forming) activity" BROAD [EC:4.1.2.47]
synonym: "(S)-cyanohydrin producing hydroxynitrile lyase activity" BROAD [EC:4.1.2.47]
synonym: "(S)-hydroxynitrile lyase activity" BROAD [EC:4.1.2.47]
synonym: "(S)-oxynitrilase activity" BROAD [EC:4.1.2.47]
synonym: "(S)-selective hydroxynitrile lyase activity" BROAD [EC:4.1.2.47]
synonym: "hydroxynitrile lyase activity" BROAD [EC:4.1.2.47]
synonym: "oxynitrilase activity" BROAD [EC:4.1.2.47]
xref: EC:4.1.2.47
xref: MetaCyc:RXN-11731
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0052892
name: aromatic (S)-hydroxynitrile lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: an aromatic (S)-hydroxynitrile = an aromatic aldehyde + cyanide." [EC:4.1.2.47, KEGG:R09359]
synonym: "(S)-cyanohydrin carbonyl-lyase (cyanide forming) activity" BROAD [EC:4.1.2.47]
synonym: "(S)-cyanohydrin producing hydroxynitrile lyase activity" BROAD [EC:4.1.2.47]
synonym: "(S)-hydroxynitrile lyase activity" BROAD [EC:4.1.2.47]
synonym: "(S)-oxynitrilase activity" BROAD [EC:4.1.2.47]
synonym: "(S)-selective hydroxynitrile lyase activity" BROAD [EC:4.1.2.47]
synonym: "hydroxynitrile lyase activity" BROAD [EC:4.1.2.47]
synonym: "oxynitrilase activity" BROAD [EC:4.1.2.47]
xref: EC:4.1.2.47
xref: KEGG:R09359
xref: MetaCyc:RXN-11732
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0052893
name: N1-acetylspermine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: N1-acetylspermine + oxygen + H2O = N-(3-acetamidopropyl)-4-aminobutanal + propane-1,3-diamine + hydrogen peroxide." [MetaCyc:RXN-10465]
synonym: "polyamine oxidase (propane-1,3-diamine-forming) activity" BROAD [EC:1.5.3.14]
xref: EC:1.5.3.14
xref: MetaCyc:RXN-10465
is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor

[Term]
id: GO:0052894
name: norspermine:oxygen oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: norspermine + oxygen + H2O = norspermidine + 3-aminopropanal + hydrogen peroxide." [MetaCyc:RXN-10464]
synonym: "norspermine oxidase activity" BROAD [EC:1.5.3.16]
xref: EC:1.5.3.16
xref: MetaCyc:RXN-10464
is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor

[Term]
id: GO:0052895
name: N1-acetylspermine:oxygen oxidoreductase (N1-acetylspermidine-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: N1-acetylspermine + oxygen + H2O = N1-acetylspermidine + 3-aminopropanal + hydrogen peroxide." [MetaCyc:POLYAMINE-OXIDASE-RXN]
synonym: "N1-acetylspermine oxidase activity" BROAD [EC:1.5.3.16]
xref: EC:1.5.3.16
xref: MetaCyc:POLYAMINE-OXIDASE-RXN
is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor

[Term]
id: GO:0052896
name: spermidine oxidase (propane-1,3-diamine-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + O(2) + spermidine = 1,3-diaminopropane + 4-aminobutanal + H(2)O(2)." [RHEA:25823]
synonym: "polyamine oxidase (propane-1,3-diamine-forming) activity" BROAD [EC:1.5.3.14]
synonym: "spermidine:(acceptor) oxidoreductase activity" BROAD [EC:1.5.3.14]
xref: EC:1.5.3.14
xref: KEGG:R01914
xref: MetaCyc:RXN-10747
xref: RHEA:25823 "H(2)O + O(2) + spermidine = 1,3-diaminopropane + 4-aminobutanal + H(2)O(2)"
is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor

[Term]
id: GO:0052897
name: N8-acetylspermidine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + N(8)-acetylspermidine + O(2) = 1,3-diaminopropane + 4-acetamidobutanal + H(2)O(2)." [RHEA:25975]
synonym: "N(8)-acetylspermidine oxidase (propane-1,3-diamine-forming) activity" BROAD [EC:1.5.3.15]
xref: EC:1.5.3.15
xref: KEGG:R09075
xref: MetaCyc:RXN-10463
xref: RHEA:25975 "H(2)O + N(8)-acetylspermidine + O(2) = 1,3-diaminopropane + 4-acetamidobutanal + H(2)O(2)"
is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor

[Term]
id: GO:0052898
name: N1-acetylspermidine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + N(1)-acetylspermidine + O(2) = 1,3-diaminopropane + 4-acetamidobutanal + H(2)O(2)." [RHEA:25867]
xref: EC:1.5.3.15
xref: RHEA:25867 "H(2)O + N(1)-acetylspermidine + O(2) = 1,3-diaminopropane + 4-acetamidobutanal + H(2)O(2)"
is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor

[Term]
id: GO:0052899
name: N(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + N(1),N(12)-diacetylspermine + O(2) = 3-acetamidopropanal + H(2)O(2) + N(1)-acetylspermidine." [RHEA:25871]
synonym: "N(1)-acetylpolyamine oxidase activity" BROAD [EC:1.5.3.13]
synonym: "polyamine oxidase activity" BROAD [EC:1.5.3.13, EC:1.5.3.17]
xref: EC:1.5.3.13
xref: MetaCyc:RXN-10460
xref: RHEA:25871 "H(2)O + N(1),N(12)-diacetylspermine + O(2) = 3-acetamidopropanal + H(2)O(2) + N(1)-acetylspermidine"
is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor

[Term]
id: GO:0052900
name: spermine oxidase (propane-1,3-diamine-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + O(2) + spermine = 1,3-diaminopropane + H(2)O(2) + N-(3-aminopropyl)-4-aminobutanal." [RHEA:25827]
synonym: "polyamine oxidase (propane-1,3-diamine-forming) activity" BROAD [EC:1.5.3.14]
xref: EC:1.5.3.14
xref: MetaCyc:RXN-6421
xref: RHEA:25827 "H(2)O + O(2) + spermine = 1,3-diaminopropane + H(2)O(2) + N-(3-aminopropyl)-4-aminobutanal"
is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor

[Term]
id: GO:0052901
name: spermine:oxygen oxidoreductase (spermidine-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + O(2) + spermine = 3-aminopropanal + H(2)O(2) + spermidine." [RHEA:25807]
synonym: "N(1)-acetylpolyamine oxidase activity" BROAD [EC:1.5.3.13]
synonym: "non-specific polyamine oxidase activity" BROAD [EC:1.5.3.17]
synonym: "polyamine oxidase activity" BROAD [EC:1.5.3.13, EC:1.5.3.17]
synonym: "spermine oxidase activity" BROAD [EC:1.5.3.16]
xref: EC:1.5.3.13
xref: EC:1.5.3.16
xref: EC:1.5.3.17
xref: KEGG:R09076
xref: MetaCyc:1.5.3.17-RXN
xref: MetaCyc:RXN-9015
xref: RHEA:25807 "H(2)O + O(2) + spermine = 3-aminopropanal + H(2)O(2) + spermidine"
is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor

[Term]
id: GO:0052902
name: spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + O(2) + spermidine = 3-aminopropanal + H(2)O(2) + putrescine." [RHEA:25811]
synonym: "N(1)-acetylpolyamine oxidase activity" BROAD [EC:1.5.3.13]
synonym: "non-specific polyamine oxidase activity" BROAD [EC:1.5.3.17]
synonym: "polyamine oxidase activity" BROAD [EC:1.5.3.13, EC:1.5.3.17]
xref: EC:1.5.3.13
xref: EC:1.5.3.17
xref: KEGG:R09077
xref: MetaCyc:RXN-10461
xref: MetaCyc:RXN-12089
xref: RHEA:25811 "H(2)O + O(2) + spermidine = 3-aminopropanal + H(2)O(2) + putrescine"
is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor

[Term]
id: GO:0052903
name: N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + N(1)-acetylspermine + O(2) = 3-acetamidopropanal + H(2)O(2) + spermidine." [RHEA:25803]
synonym: "N(1)-acetylpolyamine oxidase activity" BROAD [EC:1.5.3.13]
synonym: "non-specific polyamine oxidase activity" BROAD [EC:1.5.3.17]
synonym: "polyamine oxidase activity" BROAD [EC:1.5.3.13, EC:1.5.3.17]
xref: EC:1.5.3.13
xref: EC:1.5.3.17
xref: KEGG:R03899
xref: MetaCyc:RXN-12090
xref: MetaCyc:RXN-9940
xref: RHEA:25803 "H(2)O + N(1)-acetylspermine + O(2) = 3-acetamidopropanal + H(2)O(2) + spermidine"
is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor

[Term]
id: GO:0052904
name: N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + N(1)-acetylspermidine + O(2) = 3-acetamidopropanal + H(2)O(2) + putrescine." [RHEA:25815]
synonym: "N(1)-acetylpolyamine oxidase activity" BROAD [EC:1.5.3.13]
synonym: "non-specific polyamine oxidase activity" BROAD [EC:1.5.3.17]
synonym: "polyamine oxidase activity" BROAD [EC:1.5.3.13, EC:1.5.3.17]
xref: EC:1.5.3.13
xref: EC:1.5.3.17
xref: KEGG:R09074
xref: MetaCyc:RXN-12091
xref: MetaCyc:RXN-9942
xref: RHEA:25815
is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor

[Term]
id: GO:0052905
name: tRNA (guanine(9)-N(1))-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanine(9) in tRNA = N(1)-methylguanine(9) in tRNA + S-adenosyl-L-homocysteine." [EC:2.1.1.221]
synonym: "tRNA (guanine-N(1)-)-methyltransferase activity" EXACT [EC:2.1.1.221]
synonym: "tRNA m(1)G(9) Mtase activity" EXACT [EC:2.1.1.221]
synonym: "tRNA m(1)G(9)-methyltransferase activity" EXACT [EC:2.1.1.221]
synonym: "tRNA(m(1)G(9)/m(1)A(9))-methyltransferase activity" EXACT [EC:2.1.1.221]
synonym: "tRNA(m(1)G(9)/m(1)A(9))Mtase activity" EXACT [EC:2.1.1.221]
xref: EC:2.1.1.221
xref: MetaCyc:RXN-12459
is_a: GO:0009019 ! tRNA (guanine-N1-)-methyltransferase activity

[Term]
id: GO:0052906
name: tRNA (guanine(37)-N(1))-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanine(37) in tRNA = N(1)-methylguanine(37) in tRNA + S-adenosyl-L-homocysteine." [EC:2.1.1.228]
synonym: "transfer RNA (m(1)G(37)) methyltransferase activity" EXACT [EC:2.1.1.228]
synonym: "tRNA (m(1)G(37)) methyltransferase activity" EXACT [EC:2.1.1.228]
synonym: "tRNA-(N(1)G37) methyltransferase activity" EXACT [EC:2.1.1.228]
xref: EC:2.1.1.228
xref: MetaCyc:RXN-12458
is_a: GO:0009019 ! tRNA (guanine-N1-)-methyltransferase activity

[Term]
id: GO:0052907
name: 23S rRNA (adenine(1618)-N(6))-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + adenine(1618) in 23S rRNA = S-adenosyl-L-homocysteine + rRNA containing N(6)-methyladenine(1618) in 23S rRNA." [EC:2.1.1.181]
synonym: "M(6)A(1618) activity" BROAD [EC:2.1.1.181]
synonym: "rRNA large subunit methyltransferase F activity" RELATED [EC:2.1.1.181]
xref: EC:2.1.1.181
xref: KEGG:R07232
xref: MetaCyc:RXN-11596
is_a: GO:0008988 ! rRNA (adenine-N6-)-methyltransferase activity

[Term]
id: GO:0052908
name: 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4 S-adenosyl-L-methionine + adenine(1518)/adenine(1519) in 16S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1518)/N(6)-dimethyladenine(1519) in 16S rRNA." [EC:2.1.1.182]
synonym: "S-adenosylmethionine-6-N',N'-adenosyl (rRNA) dimethyltransferase activity" EXACT [EC:2.1.1.182]
xref: EC:2.1.1.182
xref: MetaCyc:RXN-11633
is_a: GO:0008988 ! rRNA (adenine-N6-)-methyltransferase activity

[Term]
id: GO:0052909
name: 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4 S-adenosyl-L-methionine + adenine(1779)/adenine(1780) in 18S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1779)/N(6)-dimethyladenine(1780) in 18S rRNA." [EC:2.1.1.183]
synonym: "M(6)(2)A dimethylase activity" BROAD [EC:2.1.1.183]
xref: EC:2.1.1.183
xref: MetaCyc:RXN-11634
is_a: GO:0008988 ! rRNA (adenine-N6-)-methyltransferase activity

[Term]
id: GO:0052910
name: 23S rRNA (adenine(2085)-N(6))-dimethyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + adenine(2085) in 23S rRNA = 2 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(2085) in 23S rRNA." [EC:2.1.1.184]
synonym: "ermC 23S rRNA methyltransferase activity" RELATED [EC:2.1.1.184]
synonym: "rRNA methyltransferase ermC' activity" RELATED [EC:2.1.1.184]
synonym: "rRNA:m(6)A methyltransferase ermC' activity" RELATED [EC:2.1.1.184]
xref: EC:2.1.1.184
xref: MetaCyc:RXN-11597
is_a: GO:0008988 ! rRNA (adenine-N6-)-methyltransferase activity

[Term]
id: GO:0052911
name: 23S rRNA (guanine(745)-N(1))-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanine(745) in 23S rRNA = N(1)-methylguanine(745) in 23S rRNA + S-adenosyl-L-homocysteine." [EC:2.1.1.187]
synonym: "23S rRNA m(1)G(745) methyltransferase activity" EXACT [EC:2.1.1.187]
synonym: "ribosomal ribonucleate guanine 1-methyltransferase activity" BROAD [EC:2.1.1.187]
synonym: "ribosomal RNA(m(1)G)-methylase activity" BROAD [EC:2.1.1.187]
synonym: "rlmA(I) methyltransferase activity" BROAD [EC:2.1.1.187]
synonym: "rRNA(m(1)G)methylase activity" BROAD [EC:2.1.1.187]
synonym: "S-adenosyl-L-methionine:rRNA (guanine-1-N-)-methyltransferase activity" BROAD [EC:2.1.1.187]
xref: EC:2.1.1.187
xref: KEGG:R07233
xref: MetaCyc:RXN-11573
is_a: GO:0008989 ! rRNA (guanine-N1-)-methyltransferase activity

[Term]
id: GO:0052912
name: 23S rRNA (guanine(748)-N(1))-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanine(748) in 23S rRNA = N(1)-methylguanine(748) in 23S rRNA + S-adenosyl-L-homocysteine." [EC:2.1.1.188]
synonym: "23S rRNA m(1)G(748) methyltransferase activity" BROAD [EC:2.1.1.188]
xref: EC:2.1.1.188
xref: KEGG:R07233
xref: MetaCyc:RXN-11599
is_a: GO:0008989 ! rRNA (guanine-N1-)-methyltransferase activity

[Term]
id: GO:0052913
name: 16S rRNA (guanine(966)-N(2))-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(966) in 16S rRNA = N(2)-methylguanosine(966) in 16S rRNA + S-adenosyl-L-homocysteine." [EC:2.1.1.171]
xref: EC:2.1.1.171
xref: KEGG:R07234
xref: MetaCyc:RXN0-6515
is_a: GO:0008990 ! rRNA (guanine-N2-)-methyltransferase activity

[Term]
id: GO:0052914
name: 16S rRNA (guanine(1207)-N(2))-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(1207) in 16S rRNA = N(2)-methylguanosine(1207) in 16S rRNA + S-adenosyl-L-homocysteine." [EC:2.1.1.172]
synonym: "M(2)G1207 methyltransferase activity" EXACT [EC:2.1.1.172]
xref: EC:2.1.1.172
xref: KEGG:R07234
xref: MetaCyc:RXN-11576
is_a: GO:0008990 ! rRNA (guanine-N2-)-methyltransferase activity

[Term]
id: GO:0052915
name: 23S rRNA (guanine(2445)-N(2))-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(2445) in 23S rRNA = N(2)-methylguanosine(2445) in 23S rRNA + S-adenosyl-L-homocysteine." [EC:2.1.1.173]
xref: EC:2.1.1.173
xref: KEGG:R07234
xref: MetaCyc:RXN-11574
is_a: GO:0008990 ! rRNA (guanine-N2-)-methyltransferase activity

[Term]
id: GO:0052916
name: 23S rRNA (guanine(1835)-N(2))-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(1835) in 23S rRNA = N(2)-methylguanosine(1835) in 23S rRNA + S-adenosyl-L-homocysteine." [EC:2.1.1.174]
xref: EC:2.1.1.174
xref: KEGG:R07234
xref: MetaCyc:RXN-11635
is_a: GO:0008990 ! rRNA (guanine-N2-)-methyltransferase activity

[Term]
id: GO:0052917
name: dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H(+) + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate." [EC:2.4.1.260, RHEA:29538]
synonym: "dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichyl alpha-6-mannosyltransferase activity" EXACT [EC:2.4.1.260]
synonym: "dolichyl-P-mannose:Man(7)GlcNAc(2)-PP-dolichyl mannosyltransferase activity" EXACT [EC:2.4.1.260]
xref: EC:2.4.1.260
xref: KEGG:R06260
xref: MetaCyc:RXN-5468
xref: RHEA:29538 "alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H(+) + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate"
is_a: GO:0000009 ! alpha-1,6-mannosyltransferase activity

[Term]
id: GO:0052918
name: dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H(+) + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->6))-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate." [EC:2.4.1.261, RHEA:29542]
xref: EC:2.4.1.261
xref: KEGG:R06261
xref: MetaCyc:RXN-5469
xref: RHEA:29542 "alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H(+) + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->6))-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate"
is_a: GO:0000026 ! alpha-1,2-mannosyltransferase activity

[Term]
id: GO:0052919
name: aliphatic (R)-hydroxynitrile lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: an aliphatic (R)-hydroxynitrile = an aliphatic aldehyde or ketone + hydrogen cyanide." [EC:4.1.2.46]
synonym: "(R)-HNL activity" BROAD [EC:4.1.2.46]
synonym: "(R)-hydroxynitrile lyase activity" BROAD [EC:4.1.2.46]
synonym: "(R)-oxynitrilase activity" BROAD [EC:4.1.2.46]
xref: EC:4.1.2.46
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0052920
name: (2R)-2-hydroxy-2-methylbutanenitrile lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2R)-2-hydroxy-2-methylbutanenitrile = butan-2-one + hydrogen cyanide." [EC:4.1.2.46]
xref: EC:4.1.2.46
xref: KEGG:R09358
xref: MetaCyc:RXN-11733
xref: RHEA:28173 "(2R)-2-hydroxy-2-methylbutanenitrile = butan-2-one + hydrogen cyanide"
is_a: GO:0052919 ! aliphatic (R)-hydroxynitrile lyase activity

[Term]
id: GO:0052921
name: acetone-cyanohydrin acetone-lyase (cyanide-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: acetone cyanohydrin = hydrogen cyanide + acetone." [KEGG:R01553, MetaCyc:ACETONE-CYANHYDRIN-LYASE-RXN]
xref: EC:4.1.2.46
xref: KEGG:R01553
xref: MetaCyc:ACETONE-CYANHYDRIN-LYASE-RXN
is_a: GO:0052919 ! aliphatic (R)-hydroxynitrile lyase activity

[Term]
id: GO:0052922
name: hexaprenyl diphosphate synthase (geranylgeranyl-diphosphate specific) activity
namespace: molecular_function
def: "Catalysis of the reaction: geranylgeranyl diphosphate + 2 isopentenyl diphosphate = 2 diphosphate + all-trans-hexaprenyl diphosphate." [RHEA:27558]
synonym: "(all-E) hexaprenyl diphosphate synthase activity" BROAD [EC:2.5.1.82]
synonym: "(all-trans)-hexaprenyl-diphosphate synthase activity" BROAD [EC:2.5.1.82]
synonym: "hexaprenyl diphosphate synthase activity" BROAD [EC:2.5.1.82]
synonym: "hexaprenyl pyrophosphate synthetase activity" BROAD [EC:2.5.1.82]
xref: EC:2.5.1.82
xref: KEGG:R09246
xref: MetaCyc:RXN-11485
xref: RHEA:27558 "geranylgeranyl diphosphate + 2 isopentenyl diphosphate = 2 diphosphate + all-trans-hexaprenyl diphosphate"
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0052923
name: all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity
namespace: molecular_function
def: "Catalysis of the reaction: geranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all-trans-nonaprenyl diphosphate." [EC:2.5.1.84, RHEA:27566]
synonym: "nonaprenyl diphosphate synthase activity" BROAD [EC:2.5.1.84]
synonym: "solanesyl diphosphate synthetase activity" BROAD [EC:2.5.1.84]
synonym: "solanesyl-diphosphate synthase activity" BROAD [EC:2.5.1.84]
synonym: "solPP synthase activity" BROAD [EC:2.5.1.84]
synonym: "SPP synthase activity" BROAD [EC:2.5.1.84]
synonym: "SPP-synthase activity" BROAD [EC:2.5.1.84]
xref: EC:2.5.1.84
xref: KEGG:R09250
xref: MetaCyc:TRANS-OCTAPRENYLTRANSTRANSFERASE-RXN
xref: RHEA:27566 "geranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all-trans-nonaprenyl diphosphate"
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0052924
name: all-trans-nonaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific) activity
namespace: molecular_function
def: "Catalysis of the reaction: geranylgeranyl diphosphate + 5 isopentenyl diphosphate = 5 diphosphate + all-trans-nonaprenyl diphosphate." [EC:2.5.1.85]
synonym: "nonaprenyl diphosphate synthase activity" BROAD [EC:2.5.1.85]
synonym: "solanesyl diphosphate synthase activity" BROAD [EC:2.5.1.85]
synonym: "solanesyl diphosphate synthetase activity" BROAD [EC:2.5.1.85]
xref: EC:2.5.1.85
xref: KEGG:R09251
xref: MetaCyc:RXN-11486
xref: RHEA:27597 "geranylgeranyl diphosphate + 5 isopentenyl diphosphate = 5 diphosphate + all-trans-nonaprenyl diphosphate"
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0052925
name: dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: an alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H(+) + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate." [RHEA:29530]
synonym: "dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase activity" EXACT [EC:2.4.1.258]
synonym: "man(5)GlcNAc(2)-PP-Dol mannosyltransferase activity" EXACT [EC:2.4.1.258]
xref: EC:2.4.1.258
xref: KEGG:R06258
xref: MetaCyc:RXN-5466
xref: RHEA:29530 "an alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H(+) + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate"
is_a: GO:0000033 ! alpha-1,3-mannosyltransferase activity

[Term]
id: GO:0052926
name: dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H(+) + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate." [EC:2.4.1.259, RHEA:29534]
synonym: "dolichylphosphomannose-dependent ALG9 mannosyltransferase activity" RELATED [EC:2.4.1.259]
xref: EC:2.4.1.259
xref: KEGG:R06259
xref: MetaCyc:RXN-5467
xref: RHEA:29534 "alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H(+) + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate"
is_a: GO:0000026 ! alpha-1,2-mannosyltransferase activity

[Term]
id: GO:0052927
name: CTP:tRNA cytidylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a tRNA precursor + CTP = a tRNA with a 3' cytidine end + diphosphate." [KEGG:R09383]
xref: EC:2.7.7.72
xref: KEGG:R09383
is_a: GO:0016779 ! nucleotidyltransferase activity

[Term]
id: GO:0052928
name: CTP:3'-cytidine-tRNA cytidylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a tRNA with a 3' cytidine + CTP = a tRNA with a 3' CC end + diphosphate." [KEGG:R09384]
xref: EC:2.7.7.72
xref: KEGG:R09384
is_a: GO:0016779 ! nucleotidyltransferase activity

[Term]
id: GO:0052929
name: ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a tRNA with a 3' CC end + ATP = a tRNA with a 3' CCA end + diphosphate." [KEGG:R09386]
synonym: "ATP:3'-CC-tRNA adenylyltransferase activity" EXACT []
synonym: "ATP:tRNA adenylyltransferase activity" BROAD []
xref: EC:2.7.7.72
xref: KEGG:R09386
is_a: GO:0004810 ! tRNA adenylyltransferase activity

[Term]
id: GO:0052930
name: methanol ferricytochrome-c oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: methanol + 2 ferricytochrome c = formaldehyde + 2 ferrocytochrome c + 2 H+." [KEGG:R01146]
synonym: "methanol dehydrogenase (cytochrome c) activity" BROAD [EC:1.1.2.7]
synonym: "methanol dehydrogenase activity" BROAD [EC:1.1.2.7]
xref: EC:1.1.2.7
xref: KEGG:R01146
xref: MetaCyc:RXN-2861
is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor

[Term]
id: GO:0052931
name: ethanol cytochrome-c oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: ethanol + 2 cytochrome c(L) = acetaldehyde + 2 reduced cytochrome c(L) + 2 H+." [KEGG:R09127]
synonym: "ethanol dehydrogenase (cytochrome c) activity" BROAD [EC:1.1.2.7]
synonym: "ethanol dehydrogenase activity" BROAD [EC:1.1.2.7]
xref: EC:1.1.2.7
xref: KEGG:R09127
is_a: GO:0052933 ! alcohol dehydrogenase (cytochrome c(L)) activity

[Term]
id: GO:0052932
name: 2-chloroethanol cytochrome-c oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-chloroethanol + 2 cytochrome c(L) = chloroacetaldehyde + 2 reduced cytochrome c(L)." [KEGG:R09128]
synonym: "2-chloroethanol dehydrogenase (cytochrome c) activity" BROAD [EC:1.1.2.7]
synonym: "2-chloroethanol dehydrogenase activity" BROAD [EC:1.1.2.7]
xref: EC:1.1.2.7
xref: KEGG:R09128
is_a: GO:0052933 ! alcohol dehydrogenase (cytochrome c(L)) activity

[Term]
id: GO:0052933
name: alcohol dehydrogenase (cytochrome c(L)) activity
namespace: molecular_function
def: "Catalysis of the reaction: primary alcohol + 2 cytochrome c(L) = 2 reduced cytochrome c(L) + an aldehyde + 2 H+." [EC:1.1.2.7]
synonym: "alcohol:cytochrome c(L) oxidoreductase activity" EXACT systematic_synonym [EC:1.1.2.7]
xref: EC:1.1.2.7
xref: MetaCyc:RXN-11332
is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor

[Term]
id: GO:0052934
name: alcohol dehydrogenase (cytochrome c) activity
namespace: molecular_function
def: "Catalysis of the reaction: primary alcohol + 2 cytochrome c = 2 reduced cytochrome c + an aldehyde + 2 H+." [EC:1.1.2.8]
synonym: "alcohol:cytochrome c oxidoreductase activity" EXACT systematic_synonym [EC:1.1.2.8]
synonym: "quinoprotein alcohol dehydrogenase activity" RELATED [EC:1.1.2.8]
xref: EC:1.1.2.8
xref: MetaCyc:RXN-11333
is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor

[Term]
id: GO:0052935
name: ethanol:cytochrome c oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: ethanol + 2 cytochrome c = 2 reduced cytochrome c + acetaldehyde." [KEGG:R05198]
synonym: "ethanol dehydrogenase (cytochrome c) activity" EXACT [EC:1.1.2.8]
xref: EC:1.1.2.8
xref: KEGG:R05198
is_a: GO:0052934 ! alcohol dehydrogenase (cytochrome c) activity

[Term]
id: GO:0052936
name: 2-chloroethanol:cytochrome c oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-chloroethanol + 2 cytochrome c = chloroacetaldehyde + 2 reduced cytochrome c." [KEGG:R05285]
synonym: "2-chloroethanol dehydrogenase (cytochrome c) activity" EXACT [EC:1.1.2.8]
xref: EC:1.1.2.8
xref: KEGG:R05285
is_a: GO:0052934 ! alcohol dehydrogenase (cytochrome c) activity

[Term]
id: GO:0055001
name: muscle cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate." [CL:0000187, GOC:devbiol]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0042692 ! muscle cell differentiation

[Term]
id: GO:0055002
name: striated muscle cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a striated muscle cell over time, from its formation to the mature structure. Striated muscle cells contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle." [CL:0000737, GOC:devbiol]
is_a: GO:0055001 ! muscle cell development
relationship: part_of GO:0051146 ! striated muscle cell differentiation

[Term]
id: GO:0055003
name: cardiac myofibril assembly
namespace: biological_process
def: "The process whose specific outcome is the progression of the cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells." [GOC:devbiol]
synonym: "cardiac myofibril development" EXACT []
synonym: "cardiac myofibril morphogenesis" EXACT []
synonym: "heart myofibril assembly" RELATED []
is_a: GO:0030239 ! myofibril assembly
relationship: part_of GO:0055013 ! cardiac muscle cell development

[Term]
id: GO:0055004
name: atrial cardiac myofibril assembly
namespace: biological_process
def: "The process whose specific outcome is the progression of the atrial cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells." [GOC:devbiol]
synonym: "atrial cardiac myofibril development" EXACT [GOC:dph]
synonym: "atrial heart myofibril development" EXACT []
is_a: GO:0055003 ! cardiac myofibril assembly
relationship: part_of GO:0055014 ! atrial cardiac muscle cell development

[Term]
id: GO:0055005
name: ventricular cardiac myofibril assembly
namespace: biological_process
def: "The process whose specific outcome is the progression of the ventricular cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells." [GOC:devbiol]
synonym: "ventricular cardiac myofibril development" RELATED []
synonym: "ventricular heart myofibril development" EXACT []
is_a: GO:0055003 ! cardiac myofibril assembly
relationship: part_of GO:0055015 ! ventricular cardiac muscle cell development

[Term]
id: GO:0055006
name: cardiac cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cardiac cell over time, from its formation to the mature state. A cardiac cell is a cell that will form part of the cardiac organ of an individual." [GOC:devbiol]
synonym: "cardiocyte development" EXACT [GOC:dph]
synonym: "heart cell development" RELATED []
is_a: GO:0048468 ! cell development
relationship: part_of GO:0035051 ! cardiocyte differentiation

[Term]
id: GO:0055007
name: cardiac muscle cell differentiation
namespace: biological_process
def: "The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction." [GOC:devbiol, GOC:mtg_heart]
synonym: "cardiomyocyte differentiation" EXACT []
synonym: "heart muscle cell differentiation" RELATED []
is_a: GO:0035051 ! cardiocyte differentiation
is_a: GO:0051146 ! striated muscle cell differentiation
relationship: part_of GO:0048738 ! cardiac muscle tissue development

[Term]
id: GO:0055008
name: cardiac muscle tissue morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of cardiac muscle tissue are generated and organized." [GOC:devbiol]
synonym: "heart muscle morphogenesis" EXACT []
synonym: "myocardium morphogenesis" BROAD [GOC:mtg_heart]
is_a: GO:0060415 ! muscle tissue morphogenesis
relationship: part_of GO:0003007 ! heart morphogenesis
relationship: part_of GO:0048738 ! cardiac muscle tissue development

[Term]
id: GO:0055009
name: atrial cardiac muscle tissue morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of cardiac atrium muscle is generated and organized." [GOC:devbiol]
synonym: "atrial heart muscle morphogenesis" EXACT []
synonym: "atrial myocardium morphogenesis" EXACT [GOC:mtg_heart]
synonym: "cardiac atrium muscle morphogenesis" EXACT []
is_a: GO:0055008 ! cardiac muscle tissue morphogenesis
relationship: part_of GO:0003209 ! cardiac atrium morphogenesis
relationship: part_of GO:0003228 ! atrial cardiac muscle tissue development

[Term]
id: GO:0055010
name: ventricular cardiac muscle tissue morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of cardiac ventricle muscle is generated and organized." [GOC:devbiol]
synonym: "cardiac ventricle muscle morphogenesis" EXACT []
synonym: "ventricular heart muscle morphogenesis" EXACT []
is_a: GO:0055008 ! cardiac muscle tissue morphogenesis
relationship: part_of GO:0003208 ! cardiac ventricle morphogenesis
relationship: part_of GO:0003229 ! ventricular cardiac muscle tissue development

[Term]
id: GO:0055011
name: atrial cardiac muscle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a cardiac muscle cell in the atrium. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The atrium is the part of the heart that receives blood into the organ." [GOC:devbiol, GOC:mtg_heart]
synonym: "atrial cardiomyocyte differentiation" EXACT []
synonym: "atrial heart muscle cell differentiation" EXACT []
is_a: GO:0055007 ! cardiac muscle cell differentiation

[Term]
id: GO:0055012
name: ventricular cardiac muscle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a ventricular cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood out of the organ." [GOC:devbiol, GOC:mtg_heart]
synonym: "ventricular cardiomyocyte differentiation" EXACT []
synonym: "ventricular heart muscle cell differentiation" EXACT []
is_a: GO:0055007 ! cardiac muscle cell differentiation

[Term]
id: GO:0055013
name: cardiac muscle cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state." [GOC:devbiol, GOC:mtg_heart]
synonym: "cardiomyocyte cell development" EXACT [GOC:mtg_muscle]
synonym: "heart muscle cell development" EXACT []
is_a: GO:0055002 ! striated muscle cell development
is_a: GO:0055006 ! cardiac cell development
relationship: part_of GO:0055007 ! cardiac muscle cell differentiation

[Term]
id: GO:0055014
name: atrial cardiac muscle cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of an atrial cardiac muscle cell over time, from its formation to the mature state. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The atrium is the part of the heart that receives blood into the organ." [GOC:devbiol]
synonym: "atrial cardiomyocyte development" EXACT []
synonym: "atrial heart muscle development" EXACT []
is_a: GO:0055013 ! cardiac muscle cell development
relationship: part_of GO:0055011 ! atrial cardiac muscle cell differentiation

[Term]
id: GO:0055015
name: ventricular cardiac muscle cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a ventricular cardiac muscle cell over time, from its formation to the mature state. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood out of the organ." [GOC:devbiol, GOC:mtg_muscle]
synonym: "ventricular cardiomyocyte development" EXACT []
synonym: "ventricular heart muscle cell development" EXACT []
is_a: GO:0055013 ! cardiac muscle cell development
relationship: part_of GO:0055012 ! ventricular cardiac muscle cell differentiation

[Term]
id: GO:0055016
name: hypochord development
namespace: biological_process
def: "The process whose specific outcome is the progression of the hypochord over time, from its formation to the mature structure. The hypochord is a transient rod-like structure in the embryos of fish, lampreys and amphibians that is located immediately ventral to the notochord. The hypochord may play a role in positioning the dorsal aorta." [GOC:devbiol, GOC:lb]
synonym: "subnotochordal rod development" EXACT []
is_a: GO:0009888 ! tissue development
is_a: GO:0048568 ! embryonic organ development

[Term]
id: GO:0055017
name: cardiac muscle tissue growth
namespace: biological_process
def: "The increase in size or mass of a cardiac muscle, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another." [GOC:devbiol]
synonym: "heart muscle growth" EXACT []
is_a: GO:0048589 ! developmental growth
relationship: part_of GO:0048738 ! cardiac muscle tissue development
relationship: part_of GO:0060419 ! heart growth

[Term]
id: GO:0055018
name: regulation of cardiac muscle fiber development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac muscle fiber development." [GOC:vk]
synonym: "regulation of cardiac muscle fibre development" EXACT []
synonym: "regulation of heart muscle fiber development" EXACT []
is_a: GO:0060284 ! regulation of cell development
is_a: GO:2000725 ! regulation of cardiac muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048739 ! cardiac muscle fiber development
relationship: regulates GO:0048739 ! cardiac muscle fiber development

[Term]
id: GO:0055019
name: negative regulation of cardiac muscle fiber development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle fiber development." [GOC:vk]
synonym: "down regulation of cardiac muscle fiber development" EXACT []
synonym: "down-regulation of cardiac muscle fiber development" EXACT []
synonym: "downregulation of cardiac muscle fiber development" EXACT []
synonym: "inhibition of cardiac muscle fiber development" NARROW []
synonym: "negative regulation of cardiac muscle fibre development" EXACT []
synonym: "negative regulation of heart muscle fiber development" RELATED []
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0055018 ! regulation of cardiac muscle fiber development
is_a: GO:2000726 ! negative regulation of cardiac muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048739 ! cardiac muscle fiber development
relationship: negatively_regulates GO:0048739 ! cardiac muscle fiber development

[Term]
id: GO:0055020
name: positive regulation of cardiac muscle fiber development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle fiber development." [GOC:vk]
synonym: "activation of cardiac muscle fiber development" NARROW []
synonym: "positive regulation of cardiac muscle fibre development" EXACT []
synonym: "positive regulation of heart muscle fiber development" EXACT []
synonym: "stimulation of cardiac muscle fiber development" NARROW []
synonym: "up regulation of cardiac muscle fiber development" EXACT []
synonym: "up-regulation of cardiac muscle fiber development" EXACT []
synonym: "upregulation of cardiac muscle fiber development" EXACT []
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0055018 ! regulation of cardiac muscle fiber development
is_a: GO:2000727 ! positive regulation of cardiac muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048739 ! cardiac muscle fiber development
relationship: positively_regulates GO:0048739 ! cardiac muscle fiber development

[Term]
id: GO:0055021
name: regulation of cardiac muscle tissue growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac muscle growth." [GOC:vk]
is_a: GO:0055024 ! regulation of cardiac muscle tissue development
is_a: GO:0060420 ! regulation of heart growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0055017 ! cardiac muscle tissue growth
relationship: regulates GO:0055017 ! cardiac muscle tissue growth

[Term]
id: GO:0055022
name: negative regulation of cardiac muscle tissue growth
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle growth." [GOC:vk]
synonym: "down regulation of cardiac muscle growth" EXACT []
synonym: "down-regulation of cardiac muscle growth" EXACT []
synonym: "downregulation of cardiac muscle growth" EXACT []
synonym: "inhibition of cardiac muscle growth" NARROW []
synonym: "negative regulation of heart muscle growth" RELATED []
is_a: GO:0055021 ! regulation of cardiac muscle tissue growth
is_a: GO:0055026 ! negative regulation of cardiac muscle tissue development
is_a: GO:0061117 ! negative regulation of heart growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0055017 ! cardiac muscle tissue growth
relationship: negatively_regulates GO:0055017 ! cardiac muscle tissue growth

[Term]
id: GO:0055023
name: positive regulation of cardiac muscle tissue growth
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle growth." [GOC:vk]
synonym: "activation of cardiac muscle growth" NARROW []
synonym: "positive regulation of heart muscle growth" EXACT []
synonym: "stimulation of cardiac muscle growth" NARROW []
synonym: "up regulation of cardiac muscle growth" EXACT []
synonym: "up-regulation of cardiac muscle growth" EXACT []
synonym: "upregulation of cardiac muscle growth" EXACT []
is_a: GO:0055021 ! regulation of cardiac muscle tissue growth
is_a: GO:0055025 ! positive regulation of cardiac muscle tissue development
is_a: GO:0060421 ! positive regulation of heart growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0055017 ! cardiac muscle tissue growth
relationship: positively_regulates GO:0055017 ! cardiac muscle tissue growth

[Term]
id: GO:0055024
name: regulation of cardiac muscle tissue development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac muscle tissue development." [GOC:vk]
synonym: "regulation of heart muscle development" EXACT []
is_a: GO:0016202 ! regulation of striated muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048738 ! cardiac muscle tissue development
relationship: regulates GO:0048738 ! cardiac muscle tissue development

[Term]
id: GO:0055025
name: positive regulation of cardiac muscle tissue development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle tissue development." [GOC:vk]
synonym: "activation of cardiac muscle development" NARROW []
synonym: "positive regulation of heart muscle development" EXACT []
synonym: "stimulation of cardiac muscle development" NARROW []
synonym: "up regulation of cardiac muscle development" EXACT []
synonym: "up-regulation of cardiac muscle development" EXACT []
synonym: "upregulation of cardiac muscle development" EXACT []
is_a: GO:0045844 ! positive regulation of striated muscle tissue development
is_a: GO:0055024 ! regulation of cardiac muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048738 ! cardiac muscle tissue development
relationship: positively_regulates GO:0048738 ! cardiac muscle tissue development

[Term]
id: GO:0055026
name: negative regulation of cardiac muscle tissue development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle tissue development." [GOC:vk]
synonym: "down regulation of cardiac muscle development" EXACT []
synonym: "down-regulation of cardiac muscle development" EXACT []
synonym: "downregulation of cardiac muscle development" EXACT []
synonym: "inhibition of cardiac muscle development" NARROW []
synonym: "negative regulation of heart muscle development" EXACT []
is_a: GO:0045843 ! negative regulation of striated muscle tissue development
is_a: GO:0055024 ! regulation of cardiac muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048738 ! cardiac muscle tissue development
relationship: negatively_regulates GO:0048738 ! cardiac muscle tissue development

[Term]
id: GO:0055028
name: cortical microtubule
namespace: cellular_component
def: "Arrays of microtubules underlying and connected to the plasma membrane in the cortical cytosol." [GOC:mtg_sensu]
is_a: GO:0005881 ! cytoplasmic microtubule
is_a: GO:0044448 ! cell cortex part
relationship: part_of GO:0030981 ! cortical microtubule cytoskeleton

[Term]
id: GO:0055029
name: nuclear DNA-directed RNA polymerase complex
namespace: cellular_component
def: "A protein complex, located in the nucleus, that possesses DNA-directed RNA polymerase activity." [GOC:mtg_sensu]
is_a: GO:0000428 ! DNA-directed RNA polymerase complex
is_a: GO:0044428 ! nuclear part
intersection_of: GO:0000428 ! DNA-directed RNA polymerase complex
intersection_of: part_of GO:0005634 ! nucleus
relationship: part_of GO:0005634 ! nucleus

[Term]
id: GO:0055031
name: gamma-tubulin large complex, equatorial microtubule organizing center
namespace: cellular_component
def: "A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes located at equatorial microtubule organizing centers." [GOC:mtg_sensu]
synonym: "gamma-tubulin large complex, eMTOC" EXACT []
synonym: "gamma-tubulin large complex, equatorial microtubule organizing centre" EXACT []
is_a: GO:0000931 ! gamma-tubulin large complex
is_a: GO:0032155 ! cell division site part
intersection_of: GO:0000931 ! gamma-tubulin large complex
intersection_of: part_of GO:0000923 ! equatorial microtubule organizing center
relationship: part_of GO:0000923 ! equatorial microtubule organizing center

[Term]
id: GO:0055032
name: gamma-tubulin large complex, spindle pole body
namespace: cellular_component
def: "A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes located in the spindle pole body." [GOC:mtg_sensu]
is_a: GO:0000931 ! gamma-tubulin large complex
intersection_of: GO:0000931 ! gamma-tubulin large complex
intersection_of: part_of GO:0005816 ! spindle pole body
relationship: part_of GO:0005816 ! spindle pole body

[Term]
id: GO:0055033
name: gamma-tubulin large complex, interphase microtubule organizing center
namespace: cellular_component
def: "A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes located at interphase microtubule organizing centers." [GOC:mtg_sensu]
synonym: "gamma-tubulin large complex, iMTOC" EXACT []
synonym: "gamma-tubulin large complex, interphase microtubule organizing centre" EXACT []
is_a: GO:0000931 ! gamma-tubulin large complex
intersection_of: GO:0000931 ! gamma-tubulin large complex
intersection_of: part_of GO:0031021 ! interphase microtubule organizing center
relationship: part_of GO:0031021 ! interphase microtubule organizing center

[Term]
id: GO:0055034
name: Bolwig's organ development
namespace: biological_process
def: "The process whose specific outcome is the progression of the Bolwig's organ over time, from its formation to the mature structure. The larval eye in Drosophila is a relatively simple sensory system composed of Bolwig's organs: two clusters, each composed of 12 photoreceptor cells from which axons extend in a single fascicle to the brain." [GOC:mtg_sensu]
is_a: GO:0001654 ! eye development

[Term]
id: GO:0055035
name: plastid thylakoid membrane
namespace: cellular_component
def: "The lipid bilayer membrane of any thylakoid within a plastid." [GOC:jid, GOC:rph]
is_a: GO:0042651 ! thylakoid membrane
is_a: GO:0044435 ! plastid part
relationship: part_of GO:0031976 ! plastid thylakoid

[Term]
id: GO:0055036
name: virion membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a virion." [GOC:jid, GOC:rph, PMID:213106]
subset: goslim_chembl
is_a: GO:0016020 ! membrane
is_a: GO:0044423 ! virion part

[Term]
id: GO:0055037
name: recycling endosome
namespace: cellular_component
def: "An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]
synonym: "endosomal recycling compartment" EXACT [PMID:20820847]
synonym: "endosome recycling compartment" RELATED [GOC:dph, PMID:12370264]
synonym: "ERC" RELATED [GOC:dph, PMID:1237064]
is_a: GO:0005768 ! endosome

[Term]
id: GO:0055038
name: recycling endosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a recycling endosome." [GOC:jid, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101]
is_a: GO:0010008 ! endosome membrane
relationship: part_of GO:0055037 ! recycling endosome

[Term]
id: GO:0055039
name: trichocyst
namespace: cellular_component
def: "A crystalline exocytotic organelle composed of small, acidic proteins existing primarily as disulphide-linked dimers. The trichocyst is an organelle that releases long filamentous proteins that capture predators in \"nets\" to slow them down when the cell is disturbed. The protein is nontoxic and shaped like a long, striated, fibrous shaft." [GOC:jid, GOC:rph, http://www.iscid.org/encyclopedia/, PMID:3667715]
xref: Wikipedia:Trichocyst
is_a: GO:0043264 ! extracellular non-membrane-bounded organelle

[Term]
id: GO:0055040
name: periplasmic flagellum
namespace: cellular_component
def: "Flagellar filaments located in the periplasmic space; characterized in spirochetes, in which they are essential for shape and motility. Composed of a core surrounded by two sheath layers, the flagella rotate to allow migration of the cell through viscous media, which would not be possible using external flagella." [GOC:jid, GOC:rph, PMID:15175283, PMID:1624463]
is_a: GO:0009288 ! bacterial-type flagellum
relationship: part_of GO:0042597 ! periplasmic space

[Term]
id: GO:0055041
name: cyclopentanol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyclopentanol + NAD(+) = cyclopentanone + H(+) + NADH." [EC:1.1.1.163, RHEA:11731]
synonym: "cyclopentanol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.163]
synonym: "cyclopentanol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.163]
xref: EC:1.1.1.163
xref: KEGG:R02553
xref: MetaCyc:CYCLOPENTANOL-DEHYDROGENASE-RXN
xref: RHEA:11731
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0055042
name: 5-valerolactone hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-valerolactone + H2O = 5-hydroxyvalerate." [GOC:jid, GOC:mlg]
is_a: GO:0046573 ! lactonohydrolase activity

[Term]
id: GO:0055043
name: 5-oxovalerate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-oxovalerate + NADP+ + H2O = glutarate + NADPH + H+." [GOC:jid, GOC:mlg]
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0055044
name: symplast
namespace: cellular_component
def: "The interconnected cell membranes and intracellular regions of a plant. The interconnections occur via the plasmodesmata." [GOC:mtg_sensu]
subset: goslim_pir
xref: Wikipedia:Symplast
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0055045
name: antipodal cell degeneration
namespace: biological_process
def: "The process in which the antipodal cells undergo programmed cell death." [GOC:mtg_plant]
is_a: GO:0010623 ! developmental programmed cell death
relationship: part_of GO:0009561 ! megagametogenesis

[Term]
id: GO:0055046
name: microgametogenesis
namespace: biological_process
def: "The process whose specific outcome is the progression of the pollen grain over time, from its formation as the microspore to the mature structure." [GOC:mtg_plant]
synonym: "pollen development from the microspore" EXACT systematic_synonym []
xref: Wikipedia:Microgametogenesis
is_a: GO:0044707 ! single-multicellular organism process
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0009555 ! pollen development

[Term]
id: GO:0055047
name: generative cell mitosis
namespace: biological_process
def: "The process in which the generative cell divides by mitosis to form two haploid cells. These will subsequently differentiate into sperm cells." [GOC:mtg_plant]
is_a: GO:0007067 ! mitotic nuclear division
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
relationship: part_of GO:0048232 ! male gamete generation

[Term]
id: GO:0055048
name: anastral spindle assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart, in the absence of centrosomes. Formation is initiated by the nucleation of microtubules (MTs) in the vicinity of condensed chromatin. MTs then attach to and congress around the chromatin due to activity of microtubule motors. A bipolar spindle is formed by focusing of the terminal ends of the MT array into spindle poles by molecular motors and cross-linking proteins." [GOC:expert_rg, GOC:mtg_sensu, GOC:tb, PMID:15034926]
is_a: GO:0051225 ! spindle assembly

[Term]
id: GO:0055049
name: astral spindle assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart, in the presence of centrosomes." [GOC:tb]
is_a: GO:0051225 ! spindle assembly

[Term]
id: GO:0055050
name: astral spindle assembly involved in male meiosis
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the astral spindle in male meiotic cells." [GOC:tb]
is_a: GO:0007053 ! spindle assembly involved in male meiosis
is_a: GO:0055049 ! astral spindle assembly
intersection_of: GO:0055049 ! astral spindle assembly
intersection_of: part_of GO:0007140 ! male meiosis
relationship: part_of GO:0007140 ! male meiosis

[Term]
id: GO:0055051
name: ATP-binding cassette (ABC) transporter complex, integrated substrate binding
namespace: cellular_component
def: "A complex for the transport of metabolites out of the cell, consisting of 4 domains: two ATP-binding domains and two membrane spanning domains. In some cases, all 4 domains are contained on 1 polypeptide, while in others one ATP-binding domain and one membrane spanning domain are together on one polypeptide in what is called a \"half transporter\". Two \"half-transporters\" come together to form a functional transporter. Transport of the substrate across the membrane is driven by the hydrolysis of ATP." [GOC:mlg, GOC:mtg_sensu]
is_a: GO:0043190 ! ATP-binding cassette (ABC) transporter complex

[Term]
id: GO:0055052
name: ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
namespace: cellular_component
def: "A complex for the transport of metabolites into the cell, consisting of 5 subunits: two ATP-binding subunits, two membrane spanning subunits, and one substrate-binding subunit. In organisms with two membranes, the substrate-binding protein moves freely in the periplasmic space and joins the other subunits only when bound with substrate. In organisms with only one membrane the substrate-binding protein is tethered to the cytoplasmic membrane and associated with the other subunits. Transport of the substrate across the membrane is driven by the hydrolysis of ATP." [GOC:mlg, GOC:mtg_sensu]
is_a: GO:0043190 ! ATP-binding cassette (ABC) transporter complex

[Term]
id: GO:0055053
name: mannose:proton symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: mannose + H+ = mannose + H+." [GOC:ct]
synonym: "mannose:hydrogen symporter activity" EXACT []
is_a: GO:0009679 ! hexose:proton symporter activity
is_a: GO:0015578 ! mannose transmembrane transporter activity

[Term]
id: GO:0055054
name: fructose:proton symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: fructose + H+ = fructose + H+." [GOC:ct]
synonym: "fructose:hydrogen symporter activity" EXACT []
is_a: GO:0005353 ! fructose transmembrane transporter activity
is_a: GO:0009679 ! hexose:proton symporter activity

[Term]
id: GO:0055055
name: D-glucose:proton symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-glucose + H+ = D-glucose + H+. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. D-glucose is the dextrorotatory D-enantiomer of glucose." [GOC:ct]
synonym: "D-glucose:hydrogen symporter activity" EXACT []
is_a: GO:0005356 ! hydrogen:glucose symporter activity
is_a: GO:0055056 ! D-glucose transmembrane transporter activity

[Term]
id: GO:0055056
name: D-glucose transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of the D-enantiomer of the hexose monosaccharide glucose from one side of the membrane to the other." [GOC:jid, GOC:jsg, GOC:mah]
xref: Reactome:REACT_104497 "Glucose transport by class I GLUTs, Taeniopygia guttata"
xref: Reactome:REACT_104571 "Glucose transport by class I GLUTs, Mus musculus"
xref: Reactome:REACT_105510 "Glucose transport by class III GLUTs, Mus musculus"
xref: Reactome:REACT_108977 "Glucose transport by class III GLUTs, Arabidopsis thaliana"
xref: Reactome:REACT_113478 "Glucose transport by class I GLUTs, Caenorhabditis elegans"
xref: Reactome:REACT_113923 "Glucose transport by class I GLUTs, Plasmodium falciparum"
xref: Reactome:REACT_114069 "Glucose transport by class I GLUTs, Dictyostelium discoideum"
xref: Reactome:REACT_114121 "Glucose transport by class I GLUTs, Mycobacterium tuberculosis"
xref: Reactome:REACT_114352 "Glucose transport by class I GLUTs, Drosophila melanogaster"
xref: Reactome:REACT_114492 "Glucose transport by class I GLUTs, Arabidopsis thaliana"
xref: Reactome:REACT_115387 "Glucose transport by class I GLUTs, Oryza sativa"
xref: Reactome:REACT_19335 "Glucose transport by class I GLUTs, Homo sapiens"
xref: Reactome:REACT_19350 "Glucose transport by class III GLUTs, Homo sapiens"
xref: Reactome:REACT_28727 "Glucose transport by class I GLUTs, Danio rerio"
xref: Reactome:REACT_32674 "Glucose transport by class I GLUTs, Rattus norvegicus"
xref: Reactome:REACT_79583 "Glucose transport by class III GLUTs, Gallus gallus"
xref: Reactome:REACT_81510 "Glucose transport by class III GLUTs, Sus scrofa"
xref: Reactome:REACT_82095 "Glucose transport by class I GLUTs, Gallus gallus"
xref: Reactome:REACT_82905 "Glucose transport by class III GLUTs, Oryza sativa"
xref: Reactome:REACT_85657 "Glucose transport by class I GLUTs, Bos taurus"
xref: Reactome:REACT_89836 "Glucose transport by class I GLUTs, Sus scrofa"
xref: Reactome:REACT_90533 "Glucose transport by class III GLUTs, Canis familiaris"
xref: Reactome:REACT_90638 "Glucose transport by class III GLUTs, Taeniopygia guttata"
xref: Reactome:REACT_90825 "Glucose transport by class III GLUTs, Xenopus tropicalis"
xref: Reactome:REACT_90843 "Glucose transport by class III GLUTs, Rattus norvegicus"
xref: Reactome:REACT_94786 "Glucose transport by class III GLUTs, Bos taurus"
xref: Reactome:REACT_97725 "Glucose transport by class I GLUTs, Xenopus tropicalis"
xref: Reactome:REACT_98252 "Glucose transport by class I GLUTs, Canis familiaris"
xref: Reactome:REACT_98261 "Glucose transport by class III GLUTs, Danio rerio"
is_a: GO:0005355 ! glucose transmembrane transporter activity

[Term]
id: GO:0055057
name: neuroblast division
namespace: biological_process
def: "The process resulting in the physical partitioning and separation of a neuroblast into daughter cells. A neuroblast is any cell that will divide and give rise to a neuron." [PMID:11163136, PMID:11250167]
synonym: "neuroblast cell division" EXACT []
is_a: GO:0036445 ! neuronal stem cell division
relationship: part_of GO:0007405 ! neuroblast proliferation

[Term]
id: GO:0055058
name: symmetric neuroblast division
namespace: biological_process
def: "The process resulting in the physical partitioning and separation of a neuroblast into two equi-potent daughter cells." [GOC:dph]
is_a: GO:0055057 ! neuroblast division

[Term]
id: GO:0055059
name: asymmetric neuroblast division
namespace: biological_process
def: "The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials." [GOC:dph]
is_a: GO:0045165 ! cell fate commitment
is_a: GO:0055057 ! neuroblast division
is_a: GO:0098722 ! asymmetric stem cell division

[Term]
id: GO:0055060
name: asymmetric neuroblast division resulting in ganglion mother cell formation
namespace: biological_process
def: "Any process resulting in the physical partitioning and separation of a neuroblast into a neuroblast and a ganglion mother cell." [GOC:dph]
is_a: GO:0014017 ! neuroblast fate commitment
is_a: GO:0055059 ! asymmetric neuroblast division

[Term]
id: GO:0055061
name: obsolete di-, tri-valent inorganic anion homeostasis
namespace: biological_process
def: "OBSOLETE. Any process involved in the maintenance of an internal steady state of divalent or trivalent inorganic anions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah]
comment: This term was made obsolete because it has been split.
synonym: "di-, tri-valent inorganic anion homeostasis" EXACT []
is_obsolete: true
consider: GO:0072505
consider: GO:0072506

[Term]
id: GO:0055062
name: phosphate ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of phosphate ions within an organism or cell." [GOC:jid, GOC:mah]
is_a: GO:0055083 ! monovalent inorganic anion homeostasis
is_a: GO:0072505 ! divalent inorganic anion homeostasis
is_a: GO:0072506 ! trivalent inorganic anion homeostasis

[Term]
id: GO:0055063
name: sulfate ion homeostasis
namespace: biological_process
alt_id: GO:0080174
def: "Any process involved in the maintenance of an internal steady state of sulfate ions within an organism or cell." [GOC:jid, GOC:mah]
synonym: "sulfate homeostasis" EXACT []
synonym: "sulphate ion homeostasis" EXACT []
is_a: GO:0072505 ! divalent inorganic anion homeostasis

[Term]
id: GO:0055064
name: chloride ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of chloride ions within an organism or cell." [GOC:jid, GOC:mah]
is_a: GO:0055083 ! monovalent inorganic anion homeostasis

[Term]
id: GO:0055065
name: metal ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of metal ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah]
subset: gosubset_prok
is_a: GO:0055080 ! cation homeostasis
is_a: GO:0098771 ! inorganic ion homeostasis

[Term]
id: GO:0055066
name: obsolete di-, tri-valent inorganic cation homeostasis
namespace: biological_process
def: "OBSOLETE. Any process involved in the maintenance of an internal steady state of divalent or trivalent cations within an organism or cell." [GOC:ceb, GOC:jid, GOC:mah]
comment: This term was made obsolete because it has been split.
subset: gosubset_prok
synonym: "di-, tri-valent inorganic cation homeostasis" EXACT []
is_obsolete: true
consider: GO:0072507
consider: GO:0072508

[Term]
id: GO:0055067
name: monovalent inorganic cation homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of monovalent inorganic cations within an organism or cell." [GOC:ai, GOC:jid, GOC:mah]
subset: gosubset_prok
is_a: GO:0055080 ! cation homeostasis
is_a: GO:0098771 ! inorganic ion homeostasis

[Term]
id: GO:0055068
name: cobalt ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of cobalt ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah]
synonym: "cobalt homeostasis" BROAD []
is_a: GO:0055076 ! transition metal ion homeostasis

[Term]
id: GO:0055069
name: zinc ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of zinc ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah]
synonym: "zinc homeostasis" BROAD []
is_a: GO:0055076 ! transition metal ion homeostasis
is_a: GO:0072507 ! divalent inorganic cation homeostasis

[Term]
id: GO:0055070
name: copper ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of copper ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah]
subset: gosubset_prok
synonym: "copper homeostasis" BROAD []
is_a: GO:0055076 ! transition metal ion homeostasis

[Term]
id: GO:0055071
name: manganese ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of manganese ions within an organism or cell." [GOC:jid, GOC:mah]
subset: gosubset_prok
synonym: "manganese homeostasis" BROAD []
is_a: GO:0055076 ! transition metal ion homeostasis

[Term]
id: GO:0055072
name: iron ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah]
subset: gosubset_prok
synonym: "iron homeostasis" BROAD []
is_a: GO:0055076 ! transition metal ion homeostasis

[Term]
id: GO:0055073
name: cadmium ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of cadmium ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah]
synonym: "cadmium homeostasis" EXACT []
is_a: GO:0055076 ! transition metal ion homeostasis
is_a: GO:0072507 ! divalent inorganic cation homeostasis

[Term]
id: GO:0055074
name: calcium ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of calcium ions within an organism or cell." [GOC:ceb, GOC:jid, GOC:mah]
synonym: "regulation of calcium ion concentration" EXACT []
is_a: GO:0055065 ! metal ion homeostasis
is_a: GO:0072507 ! divalent inorganic cation homeostasis

[Term]
id: GO:0055075
name: potassium ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of potassium ions within an organism or cell." [GOC:jid, GOC:mah]
is_a: GO:0055065 ! metal ion homeostasis
is_a: GO:0055067 ! monovalent inorganic cation homeostasis

[Term]
id: GO:0055076
name: transition metal ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of transition metal ions within an organism or cell. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [GOC:jid, GOC:mah, ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0055065 ! metal ion homeostasis

[Term]
id: GO:0055077
name: gap junction hemi-channel activity
namespace: molecular_function
def: "A wide pore channel activity that enables the transport of a solute across a membrane via a gap junction hemi-channel. Two gap junction hemi-channels coupled together form a complete gap junction." [GOC:dgh]
synonym: "connexon channel activity" EXACT []
is_a: GO:0022829 ! wide pore channel activity
relationship: part_of GO:0005243 ! gap junction channel activity

[Term]
id: GO:0055078
name: sodium ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of sodium ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah]
is_a: GO:0055065 ! metal ion homeostasis
is_a: GO:0055067 ! monovalent inorganic cation homeostasis

[Term]
id: GO:0055079
name: aluminum ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of aluminum ions within an organism or cell." [GOC:jid, GOC:lr, GOC:mah]
synonym: "aluminium ion homeostasis" EXACT [GOC:mah]
is_a: GO:0055065 ! metal ion homeostasis

[Term]
id: GO:0055080
name: cation homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of cations within an organism or cell." [GOC:ceb, GOC:jid, GOC:mah]
subset: gosubset_prok
is_a: GO:0050801 ! ion homeostasis

[Term]
id: GO:0055081
name: anion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of anions within an organism or cell." [GOC:ceb, GOC:jid, GOC:mah]
is_a: GO:0050801 ! ion homeostasis

[Term]
id: GO:0055082
name: cellular chemical homeostasis
namespace: biological_process
def: "Any biological process involved in the maintenance of an internal steady state of a chemical at the level of the cell." [GOC:isa_complete, GOC:jid]
subset: gosubset_prok
is_a: GO:0019725 ! cellular homeostasis
is_a: GO:0048878 ! chemical homeostasis

[Term]
id: GO:0055083
name: monovalent inorganic anion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of monovalent inorganic anions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah]
is_a: GO:0055081 ! anion homeostasis
is_a: GO:0098771 ! inorganic ion homeostasis

[Term]
id: GO:0055085
name: transmembrane transport
namespace: biological_process
def: "The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other" [GOC:dph, GOC:jid]
comment: Transmembrane transport requires transport of a solute across a lipid bilayer. Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane and is not traversed. For transport through the nuclear pore, consider instead the term 'nucleocytoplasmic transport ; GO:0006913' and its children. Note also that this term is not intended for use in annotating lateral movement within membranes.
subset: goslim_chembl
subset: goslim_generic
subset: goslim_pombe
subset: goslim_yeast
synonym: "membrane transport" EXACT []
xref: Reactome:REACT_100480 "SLC-mediated transmembrane transport, Taeniopygia guttata"
xref: Reactome:REACT_101577 "SLC-mediated transmembrane transport, Caenorhabditis elegans"
xref: Reactome:REACT_101877 "SLC-mediated transmembrane transport, Escherichia coli"
xref: Reactome:REACT_101975 "SLC-mediated transmembrane transport, Sus scrofa"
xref: Reactome:REACT_102348 "Transmembrane transport of small molecules, Staphylococcus aureus N315"
xref: Reactome:REACT_102897 "Transmembrane transport of small molecules, Caenorhabditis elegans"
xref: Reactome:REACT_102974 "SLC-mediated transmembrane transport, Canis familiaris"
xref: Reactome:REACT_104555 "SLC-mediated transmembrane transport, Xenopus tropicalis"
xref: Reactome:REACT_108243 "SLC-mediated transmembrane transport, Staphylococcus aureus N315"
xref: Reactome:REACT_109832 "Transmembrane transport of small molecules, Plasmodium falciparum"
xref: Reactome:REACT_110770 "ABC-family proteins mediated transport, Mus musculus"
xref: Reactome:REACT_114546 "ABC-family proteins mediated transport, Staphylococcus aureus N315"
xref: Reactome:REACT_114763 "ABC-family proteins mediated transport, Escherichia coli"
xref: Reactome:REACT_114890 "ABC-family proteins mediated transport, Plasmodium falciparum"
xref: Reactome:REACT_115378 "ABC-family proteins mediated transport, Mycobacterium tuberculosis"
xref: Reactome:REACT_15480 "ABC-family proteins mediated transport, Homo sapiens"
xref: Reactome:REACT_15518 "Transmembrane transport of small molecules, Homo sapiens"
xref: Reactome:REACT_19118 "SLC-mediated transmembrane transport, Homo sapiens"
xref: Reactome:REACT_29093 "ABC-family proteins mediated transport, Taeniopygia guttata"
xref: Reactome:REACT_29184 "SLC-mediated transmembrane transport, Gallus gallus"
xref: Reactome:REACT_29635 "Transmembrane transport of small molecules, Canis familiaris"
xref: Reactome:REACT_30969 "ABC-family proteins mediated transport, Canis familiaris"
xref: Reactome:REACT_32055 "Transmembrane transport of small molecules, Saccharomyces cerevisiae"
xref: Reactome:REACT_32223 "Transmembrane transport of small molecules, Rattus norvegicus"
xref: Reactome:REACT_32423 "SLC-mediated transmembrane transport, Bos taurus"
xref: Reactome:REACT_32713 "ABC-family proteins mediated transport, Sus scrofa"
xref: Reactome:REACT_33571 "SLC-mediated transmembrane transport, Danio rerio"
xref: Reactome:REACT_61245 "Transmembrane transport of small molecules, Bos taurus"
xref: Reactome:REACT_79086 "SLC-mediated transmembrane transport, Plasmodium falciparum"
xref: Reactome:REACT_79921 "SLC-mediated transmembrane transport, Saccharomyces cerevisiae"
xref: Reactome:REACT_80022 "ABC-family proteins mediated transport, Bos taurus"
xref: Reactome:REACT_80510 "ABC-family proteins mediated transport, Rattus norvegicus"
xref: Reactome:REACT_80848 "ABC-family proteins mediated transport, Schizosaccharomyces pombe"
xref: Reactome:REACT_80977 "ABC-family proteins mediated transport, Caenorhabditis elegans"
xref: Reactome:REACT_81024 "Transmembrane transport of small molecules, Oryza sativa"
xref: Reactome:REACT_81153 "SLC-mediated transmembrane transport, Mus musculus"
xref: Reactome:REACT_82725 "SLC-mediated transmembrane transport, Rattus norvegicus"
xref: Reactome:REACT_83770 "Transmembrane transport of small molecules, Escherichia coli"
xref: Reactome:REACT_86135 "ABC-family proteins mediated transport, Oryza sativa"
xref: Reactome:REACT_86409 "Transmembrane transport of small molecules, Drosophila melanogaster"
xref: Reactome:REACT_86576 "Transmembrane transport of small molecules, Schizosaccharomyces pombe"
xref: Reactome:REACT_87124 "SLC-mediated transmembrane transport, Oryza sativa"
xref: Reactome:REACT_88059 "ABC-family proteins mediated transport, Xenopus tropicalis"
xref: Reactome:REACT_88521 "Transmembrane transport of small molecules, Taeniopygia guttata"
xref: Reactome:REACT_88894 "Transmembrane transport of small molecules, Gallus gallus"
xref: Reactome:REACT_89376 "SLC-mediated transmembrane transport, Schizosaccharomyces pombe"
xref: Reactome:REACT_91272 "ABC-family proteins mediated transport, Arabidopsis thaliana"
xref: Reactome:REACT_91803 "SLC-mediated transmembrane transport, Mycobacterium tuberculosis"
xref: Reactome:REACT_92006 "Transmembrane transport of small molecules, Mycobacterium tuberculosis"
xref: Reactome:REACT_92624 "ABC-family proteins mediated transport, Gallus gallus"
xref: Reactome:REACT_93747 "Transmembrane transport of small molecules, Dictyostelium discoideum"
xref: Reactome:REACT_94160 "Transmembrane transport of small molecules, Mus musculus"
xref: Reactome:REACT_94393 "ABC-family proteins mediated transport, Drosophila melanogaster"
xref: Reactome:REACT_94944 "ABC-family proteins mediated transport, Danio rerio"
xref: Reactome:REACT_94972 "SLC-mediated transmembrane transport, Dictyostelium discoideum"
xref: Reactome:REACT_96633 "Transmembrane transport of small molecules, Sus scrofa"
xref: Reactome:REACT_96636 "SLC-mediated transmembrane transport, Arabidopsis thaliana"
xref: Reactome:REACT_97365 "Transmembrane transport of small molecules, Arabidopsis thaliana"
xref: Reactome:REACT_97867 "ABC-family proteins mediated transport, Saccharomyces cerevisiae"
xref: Reactome:REACT_98509 "Transmembrane transport of small molecules, Xenopus tropicalis"
xref: Reactome:REACT_98716 "SLC-mediated transmembrane transport, Drosophila melanogaster"
xref: Reactome:REACT_99579 "Transmembrane transport of small molecules, Danio rerio"
xref: Reactome:REACT_99829 "ABC-family proteins mediated transport, Dictyostelium discoideum"
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0044765 ! single-organism transport

[Term]
id: GO:0055086
name: nucleobase-containing small molecule metabolic process
namespace: biological_process
def: "The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide." [GOC:vw]
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "nucleobase, nucleoside and nucleotide metabolic process" RELATED []
synonym: "nucleobase, nucleoside and nucleotide metabolism" EXACT []
xref: Reactome:REACT_100770 "Metabolism of nucleotides, Plasmodium falciparum"
xref: Reactome:REACT_105851 "Metabolism of nucleotides, Schizosaccharomyces pombe"
xref: Reactome:REACT_107755 "Metabolism of nucleotides, Mycobacterium tuberculosis"
xref: Reactome:REACT_107894 "Metabolism of nucleotides, Rattus norvegicus"
xref: Reactome:REACT_116039 "Nucleotide metabolism, Gallus gallus"
xref: Reactome:REACT_1698 "Metabolism of nucleotides, Homo sapiens"
xref: Reactome:REACT_28046 "Metabolism of nucleotides, Drosophila melanogaster"
xref: Reactome:REACT_29205 "Metabolism of nucleotides, Dictyostelium discoideum"
xref: Reactome:REACT_29767 "Metabolism of nucleotides, Saccharomyces cerevisiae"
xref: Reactome:REACT_31512 "Metabolism of nucleotides, Sus scrofa"
xref: Reactome:REACT_33967 "Metabolism of nucleotides, Mus musculus"
xref: Reactome:REACT_77113 "Metabolism of nucleotides, Taeniopygia guttata"
xref: Reactome:REACT_78257 "Metabolism of nucleotides, Staphylococcus aureus N315"
xref: Reactome:REACT_82673 "Metabolism of nucleotides, Caenorhabditis elegans"
xref: Reactome:REACT_82902 "Metabolism of nucleotides, Canis familiaris"
xref: Reactome:REACT_82978 "Metabolism of nucleotides, Escherichia coli"
xref: Reactome:REACT_83845 "Metabolism of nucleotides, Bos taurus"
xref: Reactome:REACT_86759 "Metabolism of nucleotides, Oryza sativa"
xref: Reactome:REACT_90903 "Metabolism of nucleotides, Gallus gallus"
xref: Reactome:REACT_96600 "Metabolism of nucleotides, Danio rerio"
xref: Reactome:REACT_97332 "Metabolism of nucleotides, Arabidopsis thaliana"
xref: Reactome:REACT_99343 "Metabolism of nucleotides, Xenopus tropicalis"
is_a: GO:0006139 ! nucleobase-containing compound metabolic process
is_a: GO:0044281 ! small molecule metabolic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0055087
name: Ski complex
namespace: cellular_component
def: "A protein complex that regulates RNA degradation by the exosome complex. In Saccharomyces the complex has a heterotetrameric stoichiometry consisting of one copy each of Ski2p and Ski3 and two copies of Ski8p." [GOC:mcc, PMID:10744028, PMID:15703439, PMID:16043509, PMID:18042677]
xref: Wikipedia:Ski_complex
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0055088
name: lipid homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of lipid within an organism or cell." [GOC:BHF, GOC:rl]
is_a: GO:0048878 ! chemical homeostasis

[Term]
id: GO:0055089
name: fatty acid homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of fatty acid within an organism or cell." [GOC:BHF, GOC:rl]
is_a: GO:0055081 ! anion homeostasis
is_a: GO:0055088 ! lipid homeostasis

[Term]
id: GO:0055090
name: acylglycerol homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of acylglycerol within an organism or cell." [GOC:BHF, GOC:rl]
synonym: "glyceride homeostasis" EXACT []
is_a: GO:0055088 ! lipid homeostasis

[Term]
id: GO:0055091
name: phospholipid homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of phospholipid within an organism or cell." [GOC:BHF, GOC:rl]
is_a: GO:0055081 ! anion homeostasis
is_a: GO:0055088 ! lipid homeostasis

[Term]
id: GO:0055092
name: sterol homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of sterol within an organism or cell." [GOC:BHF, GOC:rl]
is_a: GO:0055088 ! lipid homeostasis

[Term]
id: GO:0055093
name: response to hyperoxia
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension." [GOC:kmv]
synonym: "response to hyperoxic stress" EXACT []
synonym: "response to increased oxygen tension" EXACT []
is_a: GO:0006950 ! response to stress
is_a: GO:0036296 ! response to increased oxygen levels

[Term]
id: GO:0055094
name: response to lipoprotein particle
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoprotein particle stimulus." [GOC:BHF, GOC:rl]
synonym: "response to lipoprotein particle stimulus" EXACT [GOC:dos]
is_a: GO:0009719 ! response to endogenous stimulus
is_a: GO:0010033 ! response to organic substance

[Term]
id: GO:0055095
name: lipoprotein particle mediated signaling
namespace: biological_process
def: "A series of molecular signals mediated by the detection of a lipoprotein particle." [GOC:BHF, GOC:rl]
synonym: "lipoprotein mediated signalling" EXACT []
synonym: "lipoprotein particle mediated signal transduction" EXACT [GOC:signaling]
synonym: "lipoprotein particle-mediated signaling" EXACT []
is_a: GO:0007165 ! signal transduction
relationship: part_of GO:0071402 ! cellular response to lipoprotein particle stimulus

[Term]
id: GO:0055096
name: low-density lipoprotein particle mediated signaling
namespace: biological_process
def: "A series of molecular signals mediated by the detection of low-density lipoprotein particle." [GOC:BHF, GOC:rl, PMID:16013438]
synonym: "low-density lipoprotein mediated signalling" EXACT []
synonym: "low-density lipoprotein particle mediated signal transduction" EXACT [GOC:signaling]
synonym: "low-density lipoprotein particle-mediated signaling" EXACT []
is_a: GO:0055095 ! lipoprotein particle mediated signaling
relationship: part_of GO:0071404 ! cellular response to low-density lipoprotein particle stimulus

[Term]
id: GO:0055097
name: high density lipoprotein particle mediated signaling
namespace: biological_process
def: "A series of molecular signals mediated by the detection of high density lipoprotein particle." [GOC:BHF, GOC:rl]
synonym: "high density lipoprotein mediated signalling" EXACT []
synonym: "high density lipoprotein particle mediated signal transduction" EXACT [GOC:signaling]
synonym: "high density lipoprotein particle-mediated signaling" EXACT []
is_a: GO:0055095 ! lipoprotein particle mediated signaling
relationship: part_of GO:0071403 ! cellular response to high density lipoprotein particle stimulus

[Term]
id: GO:0055098
name: response to low-density lipoprotein particle
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low-density lipoprotein particle stimulus." [GOC:BHF, GOC:rl]
synonym: "response to low-density lipoprotein particle stimulus" EXACT [GOC:dos]
is_a: GO:0055094 ! response to lipoprotein particle

[Term]
id: GO:0055099
name: response to high density lipoprotein particle
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high density lipoprotein particle stimulus." [GOC:BHF, GOC:rl]
synonym: "response to high density lipoprotein particle stimulus" EXACT [GOC:dos]
is_a: GO:0055094 ! response to lipoprotein particle

[Term]
id: GO:0055100
name: adiponectin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with adiponectin, a protein hormone produced by adipose tissue that modulates a number of metabolic processes, including glucose regulation and fatty acid catabolism." [GOC:BHF, GOC:rl, PMID:15210937]
is_a: GO:0005515 ! protein binding
is_a: GO:0042562 ! hormone binding

[Term]
id: GO:0055101
name: obsolete glycerophospholipase inhibitor activity
namespace: molecular_function
def: "OBSOLETE. Stops, prevents or reduces the activity of a glycerophospholipase, an enzyme that catalyzes of the hydrolysis of a glycerophospholipid." [GOC:ai, GOC:BHF, GOC:rl]
comment: This term was made obsolete because it refers to a non-existent molecular function term, 'glycerophosphate activity', which also cannot be found in the literature.
synonym: "glycerophospholipase inhibitor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0055102
name: lipase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid." [GOC:BHF, GOC:rl]
is_a: GO:0004857 ! enzyme inhibitor activity
relationship: negatively_regulates GO:0016298 ! lipase activity

[Term]
id: GO:0055103
name: ligase regulator activity
namespace: molecular_function
def: "Modulates the activity of a ligase." [GOC:BHF, GOC:rl]
is_a: GO:0030234 ! enzyme regulator activity
relationship: regulates GO:0016874 ! ligase activity

[Term]
id: GO:0055104
name: ligase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a ligase." [GOC:BHF, GOC:rl]
is_a: GO:0004857 ! enzyme inhibitor activity
relationship: negatively_regulates GO:0016874 ! ligase activity

[Term]
id: GO:0055105
name: ubiquitin-protein transferase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a ubiquitin-protein transferase." [GOC:BHF, GOC:rl]
is_a: GO:0004857 ! enzyme inhibitor activity
is_a: GO:0055106 ! ubiquitin-protein transferase regulator activity
relationship: negatively_regulates GO:0004842 ! ubiquitin-protein transferase activity
relationship: part_of GO:0031397 ! negative regulation of protein ubiquitination

[Term]
id: GO:0055106
name: ubiquitin-protein transferase regulator activity
namespace: molecular_function
def: "Modulates the activity of a ubiquitin-protein transferase, an enzyme that catalyzes the covalent attachment of ubiquitin to lysine in a substrate protein." [GOC:BHF, GOC:rl]
is_a: GO:0055103 ! ligase regulator activity
relationship: regulates GO:0004842 ! ubiquitin-protein transferase activity

[Term]
id: GO:0055107
name: Golgi to secretory granule transport
namespace: biological_process
def: "The directed movement of proteins from the Golgi to a secretory granule. The secretory granule is a membrane-bounded particle, usually protein, formed in the granular endoplasmic reticulum and the Golgi complex." [GOC:curators]
is_a: GO:1902582 ! single-organism intracellular transport
relationship: occurs_in GO:0005737 ! cytoplasm

[Term]
id: GO:0055108
name: Golgi to transport vesicle transport
namespace: biological_process
def: "The directed movement of proteins from the Golgi to a transport vesicle. Continuously secreted proteins are sorted into transport vesicles that fuse with the plasma membrane, releasing their contents by exocytosis." [GOC:jid]
is_a: GO:1902582 ! single-organism intracellular transport
relationship: occurs_in GO:0005737 ! cytoplasm
relationship: part_of GO:0048193 ! Golgi vesicle transport

[Term]
id: GO:0055109
name: invagination involved in gastrulation with mouth forming second
namespace: biological_process
def: "The infolding of the epithelial sheet into the embryo involved in deuterostomic gastrulation." [ISBN:0878932437]
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0060571 ! morphogenesis of an epithelial fold
relationship: part_of GO:0001702 ! gastrulation with mouth forming second

[Term]
id: GO:0055110
name: involution involved in gastrulation with mouth forming second
namespace: biological_process
def: "The inturning of an epithelial sheet over the basal surface of an outer layer involved in deuterostomic gastrulation." [ISBN:0878932437]
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0060571 ! morphogenesis of an epithelial fold
relationship: part_of GO:0001702 ! gastrulation with mouth forming second

[Term]
id: GO:0055111
name: ingression involved in gastrulation with mouth forming second
namespace: biological_process
def: "The migration of individual cells into the embryo involved in deuterostomic gastrulation." [ISBN:0878932437]
is_a: GO:0042074 ! cell migration involved in gastrulation
intersection_of: GO:0001667 ! ameboidal-type cell migration
intersection_of: part_of GO:0001702 ! gastrulation with mouth forming second
relationship: part_of GO:0001702 ! gastrulation with mouth forming second

[Term]
id: GO:0055112
name: delamination involved in gastrulation with mouth forming second
namespace: biological_process
def: "The splitting or migration of one epithelial sheet into two involved in the process of deuterostomic gastrulation." [ISBN:0878932437]
is_a: GO:0060232 ! delamination
intersection_of: GO:0060232 ! delamination
intersection_of: part_of GO:0001702 ! gastrulation with mouth forming second
relationship: part_of GO:0001702 ! gastrulation with mouth forming second

[Term]
id: GO:0055113
name: epiboly involved in gastrulation with mouth forming second
namespace: biological_process
def: "The expansion of one cell sheet over other cells involved in deuterostomic gastrulation." [ISBN:0878932437]
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0090504 ! epiboly
intersection_of: GO:0090504 ! epiboly
intersection_of: part_of GO:0001702 ! gastrulation with mouth forming second
relationship: part_of GO:0001702 ! gastrulation with mouth forming second

[Term]
id: GO:0055114
name: oxidation-reduction process
namespace: biological_process
def: "A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]
subset: goslim_metagenomics
subset: gosubset_prok
synonym: "oxidation reduction" EXACT [GOC:curators]
synonym: "oxidoreductase process" EXACT systematic_synonym []
xref: Wikipedia:Redox
is_a: GO:0044710 ! single-organism metabolic process

[Term]
id: GO:0055115
name: entry into diapause
namespace: biological_process
def: "The dormancy process that results in entry into diapause. Diapause is a neurohormonally mediated, dynamic state of low metabolic activity. Associated characteristics of this form of dormancy include reduced morphogenesis, increased resistance to environmental extremes, and altered or reduced behavioral activity. Full expression develops in a species-specific manner, usually in response to a number of environmental stimuli that precede unfavorable conditions. Once diapause has begun, metabolic activity is suppressed even if conditions favorable for development prevail. Once initiated, only certain stimuli are capable of releasing the organism from this state, and this characteristic is essential in distinguishing diapause from hibernation." [GOC:ds, GOC:jid, GOC:mah]
xref: Wikipedia:Diapause
is_a: GO:0022611 ! dormancy process
is_a: GO:0044767 ! single-organism developmental process

[Term]
id: GO:0055116
name: entry into reproductive diapause
namespace: biological_process
def: "The dormancy process that results in entry into reproductive diapause. Reproductive diapause is a form of diapause where the organism itself will remain fully active, including feeding and other routine activities, but the reproductive organs experience a tissue-specific reduction in metabolism, with characteristic triggering and releasing stimuli." [GOC:ds, GOC:jid, GOC:mah]
is_a: GO:0055115 ! entry into diapause

[Term]
id: GO:0055117
name: regulation of cardiac muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac muscle contraction." [GOC:ecd]
is_a: GO:0006942 ! regulation of striated muscle contraction
is_a: GO:0008016 ! regulation of heart contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060048 ! cardiac muscle contraction
relationship: regulates GO:0060048 ! cardiac muscle contraction

[Term]
id: GO:0055118
name: negative regulation of cardiac muscle contraction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle contraction." [GOC:ecd]
is_a: GO:0045822 ! negative regulation of heart contraction
is_a: GO:0045988 ! negative regulation of striated muscle contraction
is_a: GO:0055117 ! regulation of cardiac muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060048 ! cardiac muscle contraction
relationship: negatively_regulates GO:0060048 ! cardiac muscle contraction

[Term]
id: GO:0055119
name: relaxation of cardiac muscle
namespace: biological_process
def: "The process in which the extent of cardiac muscle contraction is reduced." [GOC:ecd]
is_a: GO:0090075 ! relaxation of muscle

[Term]
id: GO:0055120
name: striated muscle dense body
namespace: cellular_component
def: "A vinculin-containing myofibril attachment structure of striated muscle that connects sarcomeres to the extracellular matrix. In nematode body wall muscle, the dense body performs the dual role of Z-disk and costamere." [GOC:kmv, PMID:17492481]
is_a: GO:0044449 ! contractile fiber part

[Term]
id: GO:0055121
name: response to high fluence blue light stimulus by blue high-fluence system
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of a high fluence blue light stimulus by the blue high-fluence system. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm. The blue high-fluence system responds to blue light at levels between 100 and 1000 micromols/m2." [GOC:mtg_far_red]
synonym: "response to high fluence blue light" BROAD []
synonym: "response to high fluence blue light by bhf system" RELATED []
is_a: GO:0009637 ! response to blue light
is_a: GO:0009644 ! response to high light intensity

[Term]
id: GO:0055122
name: response to very low light intensity stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a very low light intensity stimulus. A very low light intensity stimulus is defined as a level of electromagnetic radiation below 0.001 mmol/m2/sec." [GOC:mtg_far_red]
is_a: GO:0009642 ! response to light intensity

[Term]
id: GO:0055123
name: digestive system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the digestive system over time, from its formation to the mature structure. The digestive system is the entire structure in which digestion takes place. Digestion is all of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:jid]
is_a: GO:0048731 ! system development

[Term]
id: GO:0055124
name: obsolete premature neural plate formation
namespace: biological_process
def: "The formation of the neural plate before the appropriate time." [GOC:jid]
synonym: "premature neural plate formation" EXACT []
is_obsolete: true

[Term]
id: GO:0055125
name: obsolete Nic96 complex
namespace: cellular_component
def: "OBSOLETE. A protein complex that forms part of the nuclear pore complex, and is required for its correct assembly. In Saccharomyces cerevisiae Nic96 contains Nsp1p, Nup57p, Nup49p, and Nic96p." [GOC:jh, PMID:12791264, PMID:15741174]
synonym: "Nic96 complex" EXACT []
is_obsolete: true
consider: GO:0044612
created_by: Jennifer I Deegan
creation_date: 2009-10-12T08:35:18Z

[Term]
id: GO:0055126
name: obsolete Nup82 complex
namespace: cellular_component
def: "OBSOLETE. A protein complex that forms part of the nuclear pore complex. It forms a subcomplex with Nup159p and Nsp1p, interacts with Nup116p, and is required for proper localization of Nup116p. In Saccharomyces cerevisiae this complex contains Nup82p, Nsp1p, Nup159p, Nup116p, and Gle2p." [GOC:jh, PMID:12791264, PMID:15741174]
synonym: "Nup82 complex" EXACT []
is_obsolete: true
consider: GO:0044612
created_by: Jennifer I Deegan
creation_date: 2009-10-12T08:35:34Z

[Term]
id: GO:0055127
name: vibrational conductance of sound to the inner ear
namespace: biological_process
def: "The transmission of vibrations via ossicles to the inner ear." [GOC:mh]
is_a: GO:0044707 ! single-multicellular organism process
relationship: part_of GO:0007605 ! sensory perception of sound
created_by: Jennifer I Deegan
creation_date: 2009-10-13T10:59:39Z

[Term]
id: GO:0055129
name: L-proline biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-proline, an L-enantiomer of a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [GOC:ecd]
synonym: "pyrrolidine-2-carboxylic acid biosynthetic process" BROAD []
is_a: GO:0006561 ! proline biosynthetic process
created_by: Jennifer I Deegan
creation_date: 2009-10-22T01:59:56Z

[Term]
id: GO:0055130
name: D-alanine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-alanine, the D-enantiomer of the amino acid alanine." [GOC:ecd]
synonym: "(2R)-2-aminopropanoic acid catabolic process" EXACT []
is_a: GO:0006524 ! alanine catabolic process
is_a: GO:0019478 ! D-amino acid catabolic process
is_a: GO:0046436 ! D-alanine metabolic process
created_by: Jennifer I Deegan
creation_date: 2009-10-22T02:02:42Z

[Term]
id: GO:0055131
name: C3HC4-type RING finger domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a C3HC4-type zinc finger domain of a protein. The C3HC4-type zinc finger is a variant of RING finger, is a cysteine-rich domain of 40 to 60 residues that coordinates two zinc ions, and has the consensus sequence: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid. Many proteins containing a C3HC4-type RING finger play a key role in the ubiquitination pathway." [GOC:amm, InterPro:IPR001841, InterPro:IPR018957]
is_a: GO:0019904 ! protein domain specific binding
created_by: Jennifer I Deegan
creation_date: 2009-10-22T02:20:33Z

[Term]
id: GO:0060001
name: minus-end directed microfilament motor activity
namespace: molecular_function
def: "Catalysis of movement along a microfilament towards the minus end, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). The minus end of an actin filament is the end that does not preferentially add actin monomers." [GOC:dph, PMID:10519557]
synonym: "minus-end directed actin filament motor activity" RELATED [GOC:dph]
synonym: "minus-end directed actin-filament motor activity" EXACT [GOC:dph]
synonym: "pointed-end directed actin-filament motor activity" EXACT [GOC:dph]
is_a: GO:0000146 ! microfilament motor activity

[Term]
id: GO:0060002
name: plus-end directed microfilament motor activity
namespace: molecular_function
def: "Catalysis of movement along a microfilament towards the plus end, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). The plus end of an actin filament is the end that preferentially adds actin monomers." [GOC:dph, PMID:10519557]
synonym: "barbed-end directed actin-filament motor activity" EXACT [GOC:dph]
synonym: "plus-end directed actin filament motor activity" RELATED [GOC:dph]
synonym: "plus-end directed actin-filament motor activity" EXACT [GOC:dph]
is_a: GO:0000146 ! microfilament motor activity

[Term]
id: GO:0060003
name: copper ion export
namespace: biological_process
def: "The directed movement of copper ions out of a cell or organelle." [GOC:dph]
synonym: "copper export" EXACT [GOC:dph]
is_a: GO:0035434 ! copper ion transmembrane transport

[Term]
id: GO:0060004
name: reflex
namespace: biological_process
def: "An automatic response to a stimulus beginning with a nerve impulse from a receptor and ending with the action of an effector such as a gland or a muscle. Signaling never reaches a level of consciousness." [GOC:dph, ISBN:087797099]
xref: Wikipedia:Reflex
is_a: GO:0009605 ! response to external stimulus

[Term]
id: GO:0060005
name: vestibular reflex
namespace: biological_process
def: "A reflex process in which a response to an angular or linear acceleration stimulus begins with an afferent nerve impulse from a receptor in the inner ear and ends with the compensatory action of eye muscles. Signaling never reaches a level of consciousness." [PMID:11784757]
is_a: GO:0060004 ! reflex

[Term]
id: GO:0060006
name: angular vestibuloocular reflex
namespace: biological_process
def: "A vestibular reflex by which a response to an angular acceleration stimulus begins with an afferent nerve impulse from a receptor in the semi-circular canal and ends with the compensatory action of eye muscles. Signaling never reaches a level of consciousness." [GOC:dph, PMID:11784757]
is_a: GO:0060005 ! vestibular reflex

[Term]
id: GO:0060007
name: linear vestibuloocular reflex
namespace: biological_process
def: "A vestibular reflex by which a response to a linear acceleration stimulus begins with an afferent nerve impulse from a receptor in the otolith and ends with the compensatory action of eye muscles. Signaling never reaches a level of consciousness." [GOC:dph, PMID:11784757]
is_a: GO:0060005 ! vestibular reflex

[Term]
id: GO:0060008
name: Sertoli cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a Sertoli cell. A Sertoli cell is a supporting cell projecting inward from the basement membrane of seminiferous tubules." [GOC:dph]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0030855 ! epithelial cell differentiation
is_a: GO:0044702 ! single organism reproductive process
relationship: part_of GO:0008584 ! male gonad development

[Term]
id: GO:0060009
name: Sertoli cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a Sertoli cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a Sertoli cell fate." [GOC:dph]
is_a: GO:0002064 ! epithelial cell development
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
relationship: part_of GO:0060008 ! Sertoli cell differentiation

[Term]
id: GO:0060010
name: Sertoli cell fate commitment
namespace: biological_process
def: "The process in which the cellular identity of Sertoli cells is acquired and determined." [GOC:dph]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0072148 ! epithelial cell fate commitment
relationship: part_of GO:0060008 ! Sertoli cell differentiation

[Term]
id: GO:0060011
name: Sertoli cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of Sertoli cells, resulting in the expansion of the Sertoli cell population. A Sertoli cell is a supporting cell projecting inward from the basement membrane of seminiferous tubules." [GOC:dph]
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0050673 ! epithelial cell proliferation
relationship: part_of GO:0008584 ! male gonad development

[Term]
id: GO:0060012
name: synaptic transmission, glycinergic
namespace: biological_process
def: "The process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine." [GOC:dph]
synonym: "glycinergic synaptic transmission" EXACT []
is_a: GO:0007270 ! neuron-neuron synaptic transmission

[Term]
id: GO:0060013
name: righting reflex
namespace: biological_process
def: "A reflex process in which an animal immediately tries to turn over after being placed in a supine position." [GOC:dph, PMID:8635460]
synonym: "righting response" EXACT [GOC:dph]
is_a: GO:0060004 ! reflex

[Term]
id: GO:0060014
name: granulosa cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a granulosa cell, a supporting cell for the developing female gamete in the ovary of mammals." [GOC:dph]
is_a: GO:0030855 ! epithelial cell differentiation

[Term]
id: GO:0060015
name: granulosa cell fate commitment
namespace: biological_process
def: "The cell fate commitment of precursor cells that will become granulosa cells." [GOC:dph]
is_a: GO:0072148 ! epithelial cell fate commitment
relationship: part_of GO:0060014 ! granulosa cell differentiation

[Term]
id: GO:0060016
name: granulosa cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a granulosa cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a granulosa cell fate." [GOC:dph]
is_a: GO:0002064 ! epithelial cell development
relationship: part_of GO:0060014 ! granulosa cell differentiation

[Term]
id: GO:0060017
name: parathyroid gland development
namespace: biological_process
def: "The process whose specific outcome is the progression of the parathyroid gland over time, from its formation to the mature structure. The parathyroid gland is an organ specialised for secretion of parathyroid hormone." [GOC:dph, ISBN:0721662544]
is_a: GO:0048732 ! gland development
relationship: part_of GO:0035270 ! endocrine system development

[Term]
id: GO:0060018
name: astrocyte fate commitment
namespace: biological_process
def: "The commitment of a cells to a specific astrocyte fate and its restriction to develop only into an astrocyte." [GOC:dph]
is_a: GO:0021781 ! glial cell fate commitment
relationship: part_of GO:0048708 ! astrocyte differentiation

[Term]
id: GO:0060019
name: radial glial cell differentiation
namespace: biological_process
def: "The process in which neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the brain. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:dph]
is_a: GO:0010001 ! glial cell differentiation

[Term]
id: GO:0060020
name: Bergmann glial cell differentiation
namespace: biological_process
def: "The process in which neuroepithelial cells of the neural tube give rise to Brgmann glial cells, specialized bipotential progenitors cells of the cerebellum. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:dph, PMID:10375501]
is_a: GO:0048708 ! astrocyte differentiation

[Term]
id: GO:0060021
name: palate development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of the palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The palate is the partition that separates the nasal and oral cavities." [GOC:dph, ISBN:0721662544]
synonym: "palatum development" EXACT [ISBN:0721662544]
is_a: GO:0048856 ! anatomical structure development

[Term]
id: GO:0060022
name: hard palate development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of the hard palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. The hard palate is the anterior portion of the palate consisting of bone and mucous membranes." [GOC:dph, ISBN:0721662544]
synonym: "palatum durum development" EXACT [ISBN:0721662544]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0060021 ! palate development

[Term]
id: GO:0060023
name: soft palate development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of the soft palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. The soft palate is the posterior portion of the palate extending from the posterior edge of the hard palate." [GOC:dph, ISBN:0721662544]
synonym: "palatum molle development" EXACT [ISBN:0721662544]
synonym: "velum palatum development" EXACT [ISBN:0721662544]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0060021 ! palate development

[Term]
id: GO:0060024
name: rhythmic synaptic transmission
namespace: biological_process
def: "Any process involved in the generation of rhythmic, synchronous synaptic inputs in a neural circuit." [GOC:dph]
is_a: GO:0050804 ! modulation of synaptic transmission

[Term]
id: GO:0060025
name: regulation of synaptic activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synaptic activity, the controlled release of neurotransmitters into the synaptic cleft and their subsequent detection by a postsynaptic cell." [GOC:dph, GOC:tb]
is_a: GO:0050804 ! modulation of synaptic transmission
relationship: part_of GO:0050803 ! regulation of synapse structure or activity

[Term]
id: GO:0060026
name: convergent extension
namespace: biological_process
def: "The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis." [GOC:dgf, GOC:dph, PMID:12062082]
xref: Wikipedia:Convergent_extension
is_a: GO:0002009 ! morphogenesis of an epithelium

[Term]
id: GO:0060027
name: convergent extension involved in gastrulation
namespace: biological_process
def: "The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis usually resulting in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [GOC:dph, PMID:12062082]
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0060026 ! convergent extension
intersection_of: GO:0060026 ! convergent extension
intersection_of: part_of GO:0007369 ! gastrulation
relationship: part_of GO:0007369 ! gastrulation

[Term]
id: GO:0060028
name: convergent extension involved in axis elongation
namespace: biological_process
def: "The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis contributing to the lengthening of the axis of an organism." [GOC:dph, PMID:12062082]
is_a: GO:0060026 ! convergent extension
intersection_of: GO:0060026 ! convergent extension
intersection_of: part_of GO:0003401 ! axis elongation
relationship: part_of GO:0003401 ! axis elongation

[Term]
id: GO:0060029
name: convergent extension involved in organogenesis
namespace: biological_process
def: "The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis contribution to the shaping of an organ." [GOC:dph, PMID:12062082]
is_a: GO:0060026 ! convergent extension
intersection_of: GO:0060026 ! convergent extension
intersection_of: part_of GO:0048513 ! animal organ development
relationship: part_of GO:0048513 ! animal organ development

[Term]
id: GO:0060030
name: dorsal convergence
namespace: biological_process
def: "The directed migration of individual cells and small groups of cells toward the dorsal midline during gastrulation. This process does not require cell rearrangement." [GOC:dgf, GOC:dph, PMID:12062082]
is_a: GO:0042074 ! cell migration involved in gastrulation
relationship: part_of GO:0060027 ! convergent extension involved in gastrulation

[Term]
id: GO:0060031
name: mediolateral intercalation
namespace: biological_process
def: "The interdigitation of cells along the mediolateral axis during gastrulation." [GOC:dgf, GOC:dph, PMID:12062082]
is_a: GO:0042074 ! cell migration involved in gastrulation
relationship: part_of GO:0060027 ! convergent extension involved in gastrulation

[Term]
id: GO:0060032
name: notochord regression
namespace: biological_process
def: "The developmental process in which the stucture of the notochord is destroyed in an embryo." [GOC:dph]
is_a: GO:0060033 ! anatomical structure regression
relationship: part_of GO:0048570 ! notochord morphogenesis

[Term]
id: GO:0060033
name: anatomical structure regression
namespace: biological_process
def: "The developmental process in which an anatomical stucture is destroyed as a part of its normal progression." [GOC:dph]
synonym: "histolysis" RELATED [GOC:mtg_apoptosis]
synonym: "tissue death" RELATED [GOC:mtg_apoptosis]
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0009653 ! anatomical structure morphogenesis

[Term]
id: GO:0060034
name: notochord cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features cells that make up the notochord. Differentiation includes the processes involved in commitment of a cell to a notochord cell fate." [GOC:dph]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0030903 ! notochord development

[Term]
id: GO:0060035
name: notochord cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a notochord cell over time, from its formation to its mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0060034 ! notochord cell differentiation

[Term]
id: GO:0060036
name: notochord cell vacuolation
namespace: biological_process
def: "The assembly and arrangement of a vacuole within a cell of the notochord." [GOC:cb, GOC:dph, PMID:10964477]
is_a: GO:0007033 ! vacuole organization
relationship: part_of GO:0060035 ! notochord cell development

[Term]
id: GO:0060037
name: pharyngeal system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pharyngeal system over time, from its formation to the mature structure. The pharyngeal system is a transient embryonic complex that is specific to vertebrates. It comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming: the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear." [GOC:dph]
is_a: GO:0048731 ! system development
relationship: part_of GO:0043009 ! chordate embryonic development

[Term]
id: GO:0060038
name: cardiac muscle cell proliferation
namespace: biological_process
def: "The expansion of a cardiac muscle cell population by cell division." [GOC:dph, GOC:rph, PMID:11161571]
synonym: "cardiac myocyte proliferation" EXACT []
synonym: "cardiomyocyte proliferation" RELATED [GOC:dph, PMID:10074473]
synonym: "heart muscle cell proliferation" EXACT []
is_a: GO:0014855 ! striated muscle cell proliferation
relationship: part_of GO:0055017 ! cardiac muscle tissue growth

[Term]
id: GO:0060039
name: pericardium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pericardium over time, from its formation to the mature structure. The pericardium is a double-walled sac that contains the heart and the roots of the aorta, vena cava and the pulmonary artery." [GOC:dph, GOC:rph, PMID:15138308, PMID:16376438]
is_a: GO:0060429 ! epithelium development
relationship: part_of GO:0007507 ! heart development

[Term]
id: GO:0060040
name: retinal bipolar neuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a bipolar cell, the last neuron to be generated in the retina." [GOC:ascb_2009, GOC:bf, GOC:dph, GOC:tb]
is_a: GO:0030182 ! neuron differentiation
relationship: part_of GO:0003407 ! neural retina development
relationship: part_of GO:0060042 ! retina morphogenesis in camera-type eye

[Term]
id: GO:0060041
name: retina development in camera-type eye
namespace: biological_process
alt_id: GO:0002073
def: "The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates." [GOC:bf, GOC:dph, ISBN:0815340729]
synonym: "retina development in camera-style eye" EXACT []
synonym: "retinal development" RELATED [GOC:dph, GOC:tb]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0043010 ! camera-type eye development

[Term]
id: GO:0060042
name: retina morphogenesis in camera-type eye
namespace: biological_process
def: "The process in which the anatomical structure of the retina is generated and organized." [GOC:bf, GOC:dph, GOC:mtg_sensu]
synonym: "retina morphogenesis in camera-style eye" EXACT []
synonym: "retinogenesis" EXACT []
is_a: GO:0048729 ! tissue morphogenesis
relationship: part_of GO:0048593 ! camera-type eye morphogenesis
relationship: part_of GO:0060041 ! retina development in camera-type eye

[Term]
id: GO:0060043
name: regulation of cardiac muscle cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac muscle cell proliferation." [GOC:dph, GOC:rph]
synonym: "regulation of cardiomyocyte proliferation" RELATED [GOC:dph]
synonym: "regulation of heart muscle cell proliferation" EXACT []
is_a: GO:0042127 ! regulation of cell proliferation
is_a: GO:0055021 ! regulation of cardiac muscle tissue growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060038 ! cardiac muscle cell proliferation
relationship: regulates GO:0060038 ! cardiac muscle cell proliferation

[Term]
id: GO:0060044
name: negative regulation of cardiac muscle cell proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle cell proliferation." [GOC:dph, GOC:rph]
synonym: "negative regulation of heart muscle cell proliferation" EXACT []
is_a: GO:0008285 ! negative regulation of cell proliferation
is_a: GO:0055022 ! negative regulation of cardiac muscle tissue growth
is_a: GO:0060043 ! regulation of cardiac muscle cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060038 ! cardiac muscle cell proliferation
relationship: negatively_regulates GO:0060038 ! cardiac muscle cell proliferation

[Term]
id: GO:0060045
name: positive regulation of cardiac muscle cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation." [GOC:dph, GOC:rph]
synonym: "positive regulation of heart muscle cell proliferation" RELATED []
is_a: GO:0008284 ! positive regulation of cell proliferation
is_a: GO:0055023 ! positive regulation of cardiac muscle tissue growth
is_a: GO:0060043 ! regulation of cardiac muscle cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060038 ! cardiac muscle cell proliferation
relationship: positively_regulates GO:0060038 ! cardiac muscle cell proliferation

[Term]
id: GO:0060046
name: regulation of acrosome reaction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the acrosome reaction." [GOC:dph]
is_a: GO:0017158 ! regulation of calcium ion-dependent exocytosis
is_a: GO:0043900 ! regulation of multi-organism process
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007340 ! acrosome reaction
relationship: regulates GO:0007340 ! acrosome reaction

[Term]
id: GO:0060047
name: heart contraction
namespace: biological_process
def: "The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body." [GOC:dph]
synonym: "cardiac contraction" RELATED []
synonym: "heart beating" EXACT []
synonym: "hemolymph circulation" RELATED []
is_a: GO:0003015 ! heart process
relationship: part_of GO:0008015 ! blood circulation

[Term]
id: GO:0060048
name: cardiac muscle contraction
namespace: biological_process
def: "Muscle contraction of cardiac muscle tissue." [GOC:dph]
synonym: "heart muscle contraction" EXACT []
is_a: GO:0006941 ! striated muscle contraction
relationship: part_of GO:0060047 ! heart contraction

[Term]
id: GO:0060049
name: regulation of protein glycosylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein glycosylation. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:dms, GOC:dph, GOC:pr]
synonym: "regulation of protein amino acid glycosylation" EXACT [GOC:bf]
is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process
is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process
is_a: GO:0031399 ! regulation of protein modification process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006486 ! protein glycosylation
relationship: regulates GO:0006486 ! protein glycosylation

[Term]
id: GO:0060050
name: positive regulation of protein glycosylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the glycosylation of one or more amino acid residues within a protein. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:dms, GOC:dph, GOC:pr]
synonym: "positive regulation of protein amino acid glycosylation" EXACT [GOC:bf]
is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process
is_a: GO:0031401 ! positive regulation of protein modification process
is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process
is_a: GO:0060049 ! regulation of protein glycosylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006486 ! protein glycosylation
relationship: positively_regulates GO:0006486 ! protein glycosylation

[Term]
id: GO:0060051
name: negative regulation of protein glycosylation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the glycosylation of one or more amino acid residues within a protein. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:dms, GOC:dph, GOC:pr]
synonym: "negative regulation of protein amino acid glycosylation" EXACT [GOC:bf]
is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process
is_a: GO:0031400 ! negative regulation of protein modification process
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:0060049 ! regulation of protein glycosylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006486 ! protein glycosylation
relationship: negatively_regulates GO:0006486 ! protein glycosylation

[Term]
id: GO:0060052
name: neurofilament cytoskeleton organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising neurofilaments and their associated proteins." [GOC:dph]
synonym: "neurofilament cytoskeleton organisation" EXACT [GOC:mah]
synonym: "neurofilament cytoskeleton organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0045104 ! intermediate filament cytoskeleton organization

[Term]
id: GO:0060053
name: neurofilament cytoskeleton
namespace: cellular_component
def: "Intermediate filament cytoskeletal structure that is made up of neurofilaments. Neurofilaments are specialized intermediate filaments found in neurons." [GOC:dph]
is_a: GO:0045111 ! intermediate filament cytoskeleton
is_a: GO:0097458 ! neuron part
relationship: has_part GO:0005883 ! neurofilament

[Term]
id: GO:0060054
name: positive regulation of epithelial cell proliferation involved in wound healing
namespace: biological_process
def: "Any process that activates or increases the rate or extent of epithelial cell proliferation, contributing to the restoration of integrity to a damaged tissue following an injury." [GOC:dph]
is_a: GO:0050679 ! positive regulation of epithelial cell proliferation
intersection_of: GO:0050679 ! positive regulation of epithelial cell proliferation
intersection_of: part_of GO:0042060 ! wound healing
relationship: part_of GO:0042060 ! wound healing

[Term]
id: GO:0060055
name: angiogenesis involved in wound healing
namespace: biological_process
def: "Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to a damaged tissue, following an injury." [GOC:dph, PMID:15039218]
is_a: GO:0001525 ! angiogenesis
intersection_of: GO:0001525 ! angiogenesis
intersection_of: part_of GO:0042060 ! wound healing
relationship: part_of GO:0042060 ! wound healing

[Term]
id: GO:0060056
name: mammary gland involution
namespace: biological_process
def: "The tissue remodeling that removes differentiated mammary epithelia during weaning." [GOC:dph, PMID:15282149]
is_a: GO:0048771 ! tissue remodeling
relationship: part_of GO:0060443 ! mammary gland morphogenesis

[Term]
id: GO:0060057
name: apoptotic process involved in mammary gland involution
namespace: biological_process
def: "Any apoptotic process that triggers the activity of proteolytic caspases whose actions dismantle the mammary epithelial cells resulting in their programmed cell death." [GOC:dph, GOC:mtg_apoptosis]
synonym: "apoptosis involved in mammary gland involution" NARROW []
is_a: GO:0060561 ! apoptotic process involved in morphogenesis
intersection_of: GO:0006915 ! apoptotic process
intersection_of: part_of GO:0060056 ! mammary gland involution
relationship: part_of GO:0060056 ! mammary gland involution

[Term]
id: GO:0060058
name: positive regulation of apoptotic process involved in mammary gland involution
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process of mammary epithelial cells during mammary gland involution." [GOC:dph, GOC:mtg_apoptosis, PMID:15282149]
synonym: "positive regulation of apoptosis involved in mammary gland involution" NARROW []
is_a: GO:1902339 ! positive regulation of apoptotic process involved in morphogenesis
is_a: GO:1903521 ! positive regulation of mammary gland involution
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060057 ! apoptotic process involved in mammary gland involution
relationship: positively_regulates GO:0060057 ! apoptotic process involved in mammary gland involution

[Term]
id: GO:0060059
name: embryonic retina morphogenesis in camera-type eye
namespace: biological_process
def: "The process in which the anatomical structure of the retina is generated and organized in a camera-type eye during the embryonic life stage." [GOC:dgh, GOC:dph]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0060042 ! retina morphogenesis in camera-type eye

[Term]
id: GO:0060060
name: post-embryonic retina morphogenesis in camera-type eye
namespace: biological_process
def: "The process in which the anatomical structure of the retina is generated and organized in a camera-type eye during the post-embryonic life stage." [GOC:dgh, GOC:dph]
is_a: GO:0009886 ! post-embryonic morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0060042 ! retina morphogenesis in camera-type eye

[Term]
id: GO:0060061
name: Spemann organizer formation
namespace: biological_process
def: "Formation of the specialized region on the dorsalmost side of the embryo that acts as the main signaling center establishing the vertebrate body plan." [GOC:bf, GOC:dph]
synonym: "Spemann's organizer formation" EXACT []
synonym: "Spemann-Mangold organizer formation" EXACT []
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0031128 ! developmental induction

[Term]
id: GO:0060062
name: Spemann organizer formation at the dorsal lip of the blastopore
namespace: biological_process
def: "Formation of the specialized region at the dorsal lip of the blatopore of the embryo that acts as the main signaling center establishing the vertebrate body plan." [GOC:dph, PMID:9442883]
comment: Occurs in amphibia, cephalochordates, cyclostomes and cartilaginous fish.
synonym: "Spemann's organizer formation at the dorsal lip of the blastopore" EXACT []
synonym: "Spemann-Mangold organizer formation at the dorsal lip of the blastopore" EXACT []
is_a: GO:0060061 ! Spemann organizer formation

[Term]
id: GO:0060063
name: Spemann organizer formation at the embryonic shield
namespace: biological_process
def: "Formation of the specialized region of the embryonic shield of the embryo that acts as the main signaling center establishing the teleost body plan." [GOC:dph, PMID:9442883]
comment: Occurs in Teleost fish.
synonym: "Spemann's organizer formation at the embryonic shield" EXACT []
synonym: "Spemann-Mangold organizer formation at the embryonic shield" EXACT []
is_a: GO:0060061 ! Spemann organizer formation

[Term]
id: GO:0060064
name: Spemann organizer formation at the anterior end of the primitive streak
namespace: biological_process
def: "Formation of the specialized region at the anterior end of the primitive streak of the embryo that acts as the main signaling center establishing the body plan." [GOC:dph, PMID:9442883]
comment: Occurs in reptiles, birds and mammals.
synonym: "Spemann organizer formation in amniotes" RELATED []
synonym: "Spemann's organizer formation at the anterior end of the primitive streak" EXACT []
synonym: "Spemann-Mangold organizer formation at the anterior end of the primitive streak" RELATED []
is_a: GO:0060061 ! Spemann organizer formation

[Term]
id: GO:0060065
name: uterus development
namespace: biological_process
def: "The reproductive developmental process whose specific outcome is the progression of the uterus over time, from its formation to the mature structure." [GOC:dph, GOC:ebc]
synonym: "Mullerian tract development" RELATED []
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048513 ! animal organ development
is_a: GO:0048608 ! reproductive structure development

[Term]
id: GO:0060066
name: oviduct development
namespace: biological_process
def: "The reproductive developmental process whose specific outcome is the progression of an oviduct over time, from its formation to the mature structure. An oviduct is a tube through which an ova passes from the ovary to the uterus, or from the ovary to the outside of the organism." [GOC:dph, GOC:ebc, http://www.thefreedictionary.com/oviduct]
synonym: "fallopian tube development" NARROW [GOC:bf]
synonym: "Mullerian tract development" RELATED []
is_a: GO:0035295 ! tube development
is_a: GO:0048608 ! reproductive structure development

[Term]
id: GO:0060067
name: cervix development
namespace: biological_process
def: "The reproductive developmental process whose specific outcome is the progression of the cervix over time, from its formation to the mature structure." [GOC:dph, GOC:ebc]
synonym: "Mullerian tract development" RELATED []
is_a: GO:0048608 ! reproductive structure development

[Term]
id: GO:0060068
name: vagina development
namespace: biological_process
def: "The reproductive developmental process whose specific outcome is the progression of the vagina over time, from its formation to the mature structure." [GOC:dph, GOC:ebc]
is_a: GO:0030540 ! female genitalia development

[Term]
id: GO:0060069
name: Wnt signaling pathway, regulating spindle positioning
namespace: biological_process
def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with the positioning of the mitotic spindle." [GOC:bf, GOC:dph, PMID:11532397]
synonym: "non-canonical Wnt signaling pathway" BROAD []
synonym: "Wnt receptor signaling pathway, regulating spindle positioning" EXACT []
synonym: "Wnt receptor signalling pathway, regulating spindle positioning" EXACT []
synonym: "Wnt-activated signaling pathway, regulating spindle positioning" EXACT [GOC:signaling]
is_a: GO:0007346 ! regulation of mitotic cell cycle
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0032880 ! regulation of protein localization
is_a: GO:0035567 ! non-canonical Wnt signaling pathway
is_a: GO:0060341 ! regulation of cellular localization
is_a: GO:0070507 ! regulation of microtubule cytoskeleton organization
intersection_of: GO:0035567 ! non-canonical Wnt signaling pathway
intersection_of: regulates GO:0040001 ! establishment of mitotic spindle localization
relationship: regulates GO:0040001 ! establishment of mitotic spindle localization

[Term]
id: GO:0060070
name: canonical Wnt signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [GOC:bf, GOC:dph, PMID:11532397, PMID:19619488]
synonym: "canonical Wnt receptor signaling pathway" EXACT [GOC:signaling]
synonym: "canonical Wnt-activated signaling pathway" EXACT [GOC:signaling]
synonym: "frizzled-1 receptor signaling pathway" NARROW []
synonym: "Wnt receptor signaling pathway through beta-catenin" EXACT [GOC:mtg_signal]
synonym: "Wnt receptor signaling pathway via beta-catenin" EXACT []
synonym: "Wnt receptor signalling pathway through beta-catenin" EXACT []
is_a: GO:0016055 ! Wnt signaling pathway

[Term]
id: GO:0060071
name: Wnt signaling pathway, planar cell polarity pathway
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity." [GOC:bf, GOC:dph, PMID:11532397]
synonym: "non-canonical Wnt signaling pathway" RELATED [GOC:bf]
synonym: "PCP pathway" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "planar cell polarity pathway" EXACT [GOC:cjm]
synonym: "Wnt receptor signaling pathway, planar cell polarity pathway" EXACT []
synonym: "Wnt receptor signalling pathway, planar cell polarity pathway" EXACT []
synonym: "Wnt-activated signaling pathway, planar cell polarity pathway" EXACT [GOC:signaling]
synonym: "Wnt-JNK signaling pathway" RELATED [GOC:bf]
synonym: "Wnt-PCP signaling pathway" RELATED [GOC:rph]
is_a: GO:0035567 ! non-canonical Wnt signaling pathway
is_a: GO:0090175 ! regulation of establishment of planar polarity

[Term]
id: GO:0060072
name: large conductance calcium-activated potassium channel activity
namespace: molecular_function
alt_id: GO:0022895
def: "Enables the transmembrane transfer of potassium by a channel with a unit conductance of 100 to 220 picoSiemens that opens in response to stimulus by concerted actions of internal calcium ions and membrane potential. Large conductance calcium-activated potassium channels are less sensitive to calcium than are small or intermediate conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729, PMID:17115074]
synonym: "BK calcium-activated potassium channel activity" EXACT []
synonym: "BK channel activity" RELATED []
synonym: "BK KCa channels" EXACT []
synonym: "large conductance KCa channels" EXACT []
is_a: GO:0015269 ! calcium-activated potassium channel activity

[Term]
id: GO:0060073
name: micturition
namespace: biological_process
def: "The regulation of body fluids process in which parasympathetic nerves stimulate the bladder wall muscle to contract and expel urine from the body." [GOC:dph]
synonym: "urination" EXACT []
synonym: "urine voiding" EXACT []
xref: Wikipedia:Urination
is_a: GO:0003014 ! renal system process
is_a: GO:0007588 ! excretion

[Term]
id: GO:0060074
name: synapse maturation
namespace: biological_process
def: "The process that organizes a synapse so that it attains its fully functional state. Synaptic maturation plays a critical role in the establishment of effective synaptic connections in early development." [GOC:dph, GOC:ef]
subset: goslim_synapse
synonym: "synaptic maturation" EXACT []
is_a: GO:0021700 ! developmental maturation
is_a: GO:0050808 ! synapse organization
relationship: part_of GO:0007399 ! nervous system development

[Term]
id: GO:0060075
name: regulation of resting membrane potential
namespace: biological_process
def: "Any process that modulates the establishment or extent of a resting potential, the electrical charge across the plasma membrane, with the interior of the cell negative with respect to the exterior. The resting potential is the membrane potential of a cell that is not stimulated to be depolarized or hyperpolarized." [GOC:dph, GOC:ef, ISBN:0195088433]
synonym: "regulation of resting potential" EXACT []
is_a: GO:0042391 ! regulation of membrane potential

[Term]
id: GO:0060076
name: excitatory synapse
namespace: cellular_component
def: "A synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell." [GOC:dph, GOC:ef]
xref: Wikipedia:Excitatory_synapse
is_a: GO:0045202 ! synapse

[Term]
id: GO:0060077
name: inhibitory synapse
namespace: cellular_component
def: "A synapse in which an action potential in the presynaptic cell reduces the probability of an action potential occurring in the postsynaptic cell." [GOC:dph, GOC:ef]
xref: Wikipedia:Inhibitory_postsynaptic_potential
is_a: GO:0045202 ! synapse

[Term]
id: GO:0060078
name: regulation of postsynaptic membrane potential
namespace: biological_process
def: "Any process that modulates the potential difference across a post-synaptic membrane." [GOC:dph, GOC:ef]
subset: goslim_synapse
synonym: "regulation of post-synaptic membrane potential" EXACT []
is_a: GO:0042391 ! regulation of membrane potential

[Term]
id: GO:0060079
name: excitatory postsynaptic potential
namespace: biological_process
def: "A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." [GOC:dph, GOC:ef]
synonym: "regulation of EPSP" RELATED []
synonym: "regulation of excitatory post-synaptic membrane potential" EXACT []
is_a: GO:0060078 ! regulation of postsynaptic membrane potential
relationship: part_of GO:0099565 ! chemical synaptic transmission, postsynaptic

[Term]
id: GO:0060080
name: inhibitory postsynaptic potential
namespace: biological_process
def: "A process that causes a temporary decrease in postsynaptic membrane potential due to the flow of negatively charged ions into the postsynaptic cell. The flow of ions that causes an IPSP is an inhibitory postsynaptic current (IPSC) and makes it more difficult for the neuron to fire an action potential." [GOC:dph, GOC:ef]
synonym: "IPSP" RELATED []
synonym: "regulation of inhibitory post-synaptic membrane potential" EXACT []
is_a: GO:0060078 ! regulation of postsynaptic membrane potential
relationship: part_of GO:0099565 ! chemical synaptic transmission, postsynaptic

[Term]
id: GO:0060081
name: membrane hyperpolarization
namespace: biological_process
def: "The process in which membrane potential increases with respect to its steady-state potential, usually from negative potential to a more negative potential. For example, during the repolarization phase of an action potential the membrane potential often becomes more negative or hyperpolarized before returning to the steady-state resting potential." [GOC:dph]
is_a: GO:0042391 ! regulation of membrane potential

[Term]
id: GO:0060082
name: eye blink reflex
namespace: biological_process
def: "The reflex process in which a mechanical stimulus applied to the eye elicits a response of the eyelid closing." [GOC:dph, PMID:2913208]
synonym: "nictitating membrane reflex" EXACT []
is_a: GO:0060004 ! reflex

[Term]
id: GO:0060083
name: smooth muscle contraction involved in micturition
namespace: biological_process
def: "The process leading to shortening and/or development of tension in the urinary bladder smooth muscle tissue involved in the expulsion urine from the body." [GOC:dph, PMID:15827347]
synonym: "smooth muscle contraction involved in urination" RELATED []
synonym: "urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:dph]
is_a: GO:0014832 ! urinary bladder smooth muscle contraction
intersection_of: GO:0006939 ! smooth muscle contraction
intersection_of: part_of GO:0060073 ! micturition
relationship: part_of GO:0060073 ! micturition

[Term]
id: GO:0060084
name: synaptic transmission involved in micturition
namespace: biological_process
def: "The process of communication from a neuron to a smooth muscle in the bladder that contributes to the expulsion of urine from the body." [GOC:dph, PMID:15827347]
synonym: "synaptic transmission involved in urination" RELATED []
is_a: GO:0007274 ! neuromuscular synaptic transmission
intersection_of: GO:0007268 ! synaptic transmission
intersection_of: part_of GO:0060073 ! micturition
relationship: part_of GO:0060073 ! micturition

[Term]
id: GO:0060085
name: smooth muscle relaxation of the bladder outlet
namespace: biological_process
def: "A process in which the extent of smooth muscle contraction is reduced in the bladder outlet that contributes to the expulsion of urine from the body." [GOC:dph, PMID:15827347]
synonym: "synaptic transmission involved in urination" EXACT []
is_a: GO:0044557 ! relaxation of smooth muscle
is_a: GO:0045986 ! negative regulation of smooth muscle contraction
relationship: part_of GO:0060073 ! micturition

[Term]
id: GO:0060086
name: circadian temperature homeostasis
namespace: biological_process
def: "Any homeostatic process in which an organism modulates its internal body temperature at different values with a regularity of approximately 24 hours." [GOC:dph, GOC:tb]
synonym: "circadian regulation of body temperature" RELATED []
synonym: "circadian thermoregulation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0001659 ! temperature homeostasis
is_a: GO:0007623 ! circadian rhythm

[Term]
id: GO:0060087
name: relaxation of vascular smooth muscle
namespace: biological_process
def: "A process in which the extent of vascular smooth muscle contraction is reduced. Vascular smooth muscle relaxation is mediated via a decrease in the phosphorylation state of myosin light chain. This can be achieved by removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases leading to a decrease myosin light chain kinase activity, and through calcium-independent pathways leading to a increase in myosin light chain phosphatase activity." [GOC:dph, PMID:15867178, PMID:19996365]
synonym: "vascular smooth muscle relaxation" EXACT []
is_a: GO:0044557 ! relaxation of smooth muscle
is_a: GO:0045986 ! negative regulation of smooth muscle contraction
relationship: part_of GO:0042311 ! vasodilation

[Term]
id: GO:0060088
name: auditory receptor cell stereocilium organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of auditory hair cells." [GOC:dph, PMID:10978835]
synonym: "auditory receptor cell stereocilium organisation" EXACT [GOC:curators]
synonym: "auditory receptor cell stereocilium organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0060122 ! inner ear receptor stereocilium organization
relationship: part_of GO:0002093 ! auditory receptor cell morphogenesis

[Term]
id: GO:0060089
name: molecular transducer activity
namespace: molecular_function
def: "The molecular function that accepts an input of one form and creates an output of a different form." [GOC:mtg_MIT_16mar07]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0060090
name: binding, bridging
namespace: molecular_function
def: "The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw]
subset: goslim_pir
subset: gosubset_prok
synonym: "molecular adaptor activity" EXACT []
is_a: GO:0005488 ! binding

[Term]
id: GO:0060091
name: kinocilium
namespace: cellular_component
def: "A nonmotile primary cilium that is found at the apical surface of auditory receptor cells. The kinocilium is surrounded by actin-based stereocilia." [GOC:dph, PMID:15882574]
xref: Wikipedia:Kinocilium
is_a: GO:0031513 ! nonmotile primary cilium
is_a: GO:0044422 ! organelle part
is_a: GO:0097458 ! neuron part
relationship: part_of GO:0032421 ! stereocilium bundle

[Term]
id: GO:0060092
name: regulation of synaptic transmission, glycinergic
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glycinergic synaptic transmission. Glycinergic synaptic transmission is the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine." [GOC:dms, GOC:dph]
is_a: GO:0050804 ! modulation of synaptic transmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060012 ! synaptic transmission, glycinergic
relationship: regulates GO:0060012 ! synaptic transmission, glycinergic

[Term]
id: GO:0060093
name: negative regulation of synaptic transmission, glycinergic
namespace: biological_process
def: "Any process that stops or decreases the frequency, rate or extent of glycinergic synaptic transmission. Glycinergic synaptic transmission is the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine." [GOC:dms, GOC:dph]
synonym: "negative regulation of glycinergic synaptic transmission" EXACT []
is_a: GO:0050805 ! negative regulation of synaptic transmission
is_a: GO:0060092 ! regulation of synaptic transmission, glycinergic
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060012 ! synaptic transmission, glycinergic
relationship: negatively_regulates GO:0060012 ! synaptic transmission, glycinergic

[Term]
id: GO:0060094
name: positive regulation of synaptic transmission, glycinergic
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glycinergic synaptic transmission. Glycinergic synaptic transmission is the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine." [GOC:dms, GOC:dph]
synonym: "positive regulation of glycinergic synaptic transmission" EXACT []
is_a: GO:0050806 ! positive regulation of synaptic transmission
is_a: GO:0060092 ! regulation of synaptic transmission, glycinergic
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060012 ! synaptic transmission, glycinergic
relationship: positively_regulates GO:0060012 ! synaptic transmission, glycinergic

[Term]
id: GO:0060095
name: zinc potentiation of synaptic transmission, glycinergic
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glycinergic synaptic transmission in the presence of zinc. Glycinergic synaptic transmission is the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine." [GOC:dms, GOC:dph]
synonym: "zinc potentiation of glycinergic synaptic transmission" EXACT []
is_a: GO:0060094 ! positive regulation of synaptic transmission, glycinergic

[Term]
id: GO:0060096
name: serotonin secretion, neurotransmission
namespace: biological_process
def: "The regulated release of serotonin by a cell, in which released serotonin acts as a neurotransmitter." [GOC:dph]
synonym: "serotonin release, neurotransmission" RELATED [GOC:tb]
is_a: GO:0001820 ! serotonin secretion
is_a: GO:0007269 ! neurotransmitter secretion

[Term]
id: GO:0060097
name: cytoskeletal rearrangement involved in phagocytosis, engulfment
namespace: biological_process
def: "The assembly, arrangement, or disassembly of cytoskeletal structures that is involved in the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis." [GOC:dph]
is_a: GO:0007010 ! cytoskeleton organization
intersection_of: GO:0007010 ! cytoskeleton organization
intersection_of: part_of GO:0006911 ! phagocytosis, engulfment
relationship: part_of GO:0006911 ! phagocytosis, engulfment

[Term]
id: GO:0060098
name: membrane reorganization involved in phagocytosis, engulfment
namespace: biological_process
def: "The assembly and arrangement of the plasma membrane that is involved in the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis." [GOC:dph]
synonym: "membrane reorganisation involved in phagocytosis, engulfment" EXACT [GOC:mah]
is_a: GO:0007009 ! plasma membrane organization
relationship: part_of GO:0006911 ! phagocytosis, engulfment

[Term]
id: GO:0060099
name: regulation of phagocytosis, engulfment
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis." [GOC:dph]
is_a: GO:0050764 ! regulation of phagocytosis
is_a: GO:1905153 ! regulation of membrane invagination
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006911 ! phagocytosis, engulfment
relationship: regulates GO:0006911 ! phagocytosis, engulfment

[Term]
id: GO:0060100
name: positive regulation of phagocytosis, engulfment
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis." [GOC:dph]
is_a: GO:0050766 ! positive regulation of phagocytosis
is_a: GO:0060099 ! regulation of phagocytosis, engulfment
is_a: GO:1905155 ! positive regulation of membrane invagination
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006911 ! phagocytosis, engulfment
relationship: positively_regulates GO:0006911 ! phagocytosis, engulfment

[Term]
id: GO:0060101
name: negative regulation of phagocytosis, engulfment
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis." [GOC:dph]
is_a: GO:0050765 ! negative regulation of phagocytosis
is_a: GO:0060099 ! regulation of phagocytosis, engulfment
is_a: GO:1905154 ! negative regulation of membrane invagination
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006911 ! phagocytosis, engulfment
relationship: negatively_regulates GO:0006911 ! phagocytosis, engulfment

[Term]
id: GO:0060102
name: collagen and cuticulin-based cuticle extracellular matrix
namespace: cellular_component
def: "A collagen and cuticulin-based noncellular, multilayered structure that is synthesized by an underlying ectodermal (hypodermal) cell layer. The cuticle serves essential functions in body morphology, locomotion, and environmental protection. An example of this component is found in Caenorhabditis elegans." [GOC:dph, GOC:kmv, ISSN:15518507]
synonym: "collagen and cuticulin-based exoskeleton extracellular matrix" RELATED []
is_a: GO:0005578 ! proteinaceous extracellular matrix

[Term]
id: GO:0060103
name: collagen and cuticulin-based cuticle extracellular matrix part
namespace: cellular_component
def: "Any constituent part of the collagen and cuticulin-based cuticle extracellular matrix, a collagen and cuticulin-based noncellular, multilayered structure that is synthesized by an underlying ectodermal (hypodermal) cell layer." [GOC:dph]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: goantislim_grouping
subset: gocheck_do_not_annotate
is_a: GO:0044420 ! extracellular matrix component
is_a: GO:0044421 ! extracellular region part
intersection_of: GO:0005575 ! cellular_component
intersection_of: part_of GO:0060102 ! collagen and cuticulin-based cuticle extracellular matrix
relationship: part_of GO:0060102 ! collagen and cuticulin-based cuticle extracellular matrix

[Term]
id: GO:0060104
name: surface coat of collagen and cuticulin-based cuticle extracellular matrix
namespace: cellular_component
def: "An electron dense, amorphous envelope that comprises the outermost layer of the cuticle. The surface coat is loosely apposed to the epicuticle, has distinct biochemical properties, is synthesized by cells other than the underlying hypodermis, and is labile. In addition to serving as a lubricant to protect against abrasion and dehydration, the surface coat may also play important roles in infection and immune evasion. An example of this component is found in Caenorhabditis elegans." [GOC:dph, GOC:kmv, ISSN:15518507]
synonym: "surface coat of collagen and cuticulin-based exoskeleton extracellular matrix" RELATED []
is_a: GO:0060103 ! collagen and cuticulin-based cuticle extracellular matrix part
relationship: part_of GO:0060102 ! collagen and cuticulin-based cuticle extracellular matrix

[Term]
id: GO:0060105
name: epicuticle of collagen and cuticulin-based cuticle extracellular matrix
namespace: cellular_component
def: "A lipid-containing layer of cuticle that lies between the cortical layer and the surface coat. An example of this component is found in Caenorhabditis elegans." [GOC:dph, GOC:kmv, ISSN:15518507]
synonym: "epicuticle of collagen and cuticulin-based exoskeleton extracellular matrix" RELATED []
is_a: GO:0060103 ! collagen and cuticulin-based cuticle extracellular matrix part
relationship: part_of GO:0060102 ! collagen and cuticulin-based cuticle extracellular matrix

[Term]
id: GO:0060106
name: cortical layer of collagen and cuticulin-based cuticle extracellular matrix
namespace: cellular_component
def: "The cuticle layer that lies directly beneath the lipid-containing epicuticle. The cortical layer contains collagens and insoluble, non-collagenous cuticulins and is characterized by a distinct annular pattern consisting of regularly spaced annular ridges delineated by annular furrows. An example of this component is found in Caenorhabditis elegans." [GOC:dph, GOC:kmv, ISSN:15518507]
is_a: GO:0060103 ! collagen and cuticulin-based cuticle extracellular matrix part
relationship: part_of GO:0060102 ! collagen and cuticulin-based cuticle extracellular matrix

[Term]
id: GO:0060107
name: annuli extracellular matrix
namespace: cellular_component
def: "The extracellular matrix that is a regularly spaced circumferential ridge present in the cortical region of the cuticle. Annuli are delineated by annular furrows and are present throughout the cuticle with the exception of lateral regions where longitudinal alae are present." [GOC:dph, GOC:kmv, ISSN:15518507]
synonym: "annulae" RELATED []
synonym: "annular rings" RELATED []
synonym: "annule(s)" RELATED []
synonym: "annulus" RELATED []
is_a: GO:0060103 ! collagen and cuticulin-based cuticle extracellular matrix part
relationship: part_of GO:0060106 ! cortical layer of collagen and cuticulin-based cuticle extracellular matrix

[Term]
id: GO:0060108
name: annular furrow extracellular matrix
namespace: cellular_component
def: "The extracellular matrix part that is a regularly spaced indentation in the outer cortical layer of the cuticle. The pattern of annular furrows corresponds to sites of invaginations in hypodermal cell membranes that, in turn, correspond to submembranous regions where actin microfilament bundles assemble early in lethargus, the first phase of the molting cycle in which activity and feeding decline." [GOC:dph, GOC:kmv, ISSN:15518507]
is_a: GO:0060103 ! collagen and cuticulin-based cuticle extracellular matrix part
relationship: part_of GO:0060106 ! cortical layer of collagen and cuticulin-based cuticle extracellular matrix

[Term]
id: GO:0060109
name: medial layer of collagen and cuticulin-based cuticle extracellular matrix
namespace: cellular_component
def: "The fluid-filled cuticle layer that lies between the cortical and basal layers and is characterized by the presence of regularly spaced columnar struts that lie on either side of the annular furrows and link the two surrounding layers. In C. elegans, a defined medial layer is found only in adult animals." [GOC:dph, GOC:kmv, ISSN:15518507]
synonym: "medial layer struts" RELATED []
is_a: GO:0060103 ! collagen and cuticulin-based cuticle extracellular matrix part
relationship: part_of GO:0060102 ! collagen and cuticulin-based cuticle extracellular matrix

[Term]
id: GO:0060110
name: basal layer of collagen and cuticulin-based cuticle extracellular matrix
namespace: cellular_component
def: "The layer of cuticle most closely apposed to the hypodermal cells. The morphology of the basal layer varies with life stage. In adult C. elegans animals, the basal layers is comprised of three sublayers: two fibrous layers whose fibers run in clockwise and counter-clockwise directions meeting one another at a 60 degree angle, and an amorphous basal layer that lies underneath the fibrous layers and directly contacts the hypodermis. In C. elegans dauer and L1 larval stage animals, the basal layer is characterized by a striated pattern that appears to derive from interwoven laminae. An example of this component is found in Caenorhabditis elegans." [GOC:dph, GOC:kmv, ISSN:15518507]
synonym: "basal layer of collagen and cuticulin-based exoskeleton extracellular matrix" RELATED []
is_a: GO:0060103 ! collagen and cuticulin-based cuticle extracellular matrix part
relationship: part_of GO:0060102 ! collagen and cuticulin-based cuticle extracellular matrix

[Term]
id: GO:0060111
name: alae of collagen and cuticulin-based cuticle extracellular matrix
namespace: cellular_component
def: "Raised, thickened cuticular ridges that run longitudinally, and in parallel, along the left and right sides of the animal. The alae lie above the hypodermal cells known as the lateral seam cells. In C. elegans, alae are produced in L1 larvae, dauer larvae and adult stage animals, where they consist of three, five, and three ridges of distinct morphology, respectively." [GOC:dph, GOC:kmv, ISSN:15518507]
synonym: "alae of collagen and cuticulin-based exoskeleton extracellular matrix" RELATED []
is_a: GO:0060103 ! collagen and cuticulin-based cuticle extracellular matrix part
relationship: part_of GO:0060102 ! collagen and cuticulin-based cuticle extracellular matrix

[Term]
id: GO:0060112
name: generation of ovulation cycle rhythm
namespace: biological_process
def: "The process which controls the timing of the type of sexual cycle seen in female mammals." [GOC:dph]
synonym: "generation of estrus cycle rhythm" EXACT []
synonym: "generation of menstrual cycle rhythm" RELATED []
synonym: "generation of oestrus cycle rhythm" EXACT []
is_a: GO:0022602 ! ovulation cycle process

[Term]
id: GO:0060113
name: inner ear receptor cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells, acquire specialized structural and/or functional features of inner ear receptor cells. Inner ear receptor cells are mechanorecptors found in the inner ear responsible for transducing signals involved in balance and sensory perception of sound." [GOC:dph]
synonym: "inner ear hair cell differentiation" EXACT []
is_a: GO:0042490 ! mechanoreceptor differentiation
relationship: part_of GO:0048839 ! inner ear development

[Term]
id: GO:0060114
name: vestibular receptor cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a vestibular hair cell." [GOC:dph]
synonym: "vestibular hair cell differentiation" EXACT []
is_a: GO:0035315 ! hair cell differentiation
is_a: GO:0060113 ! inner ear receptor cell differentiation

[Term]
id: GO:0060115
name: vestibular receptor cell fate commitment
namespace: biological_process
def: "The process in which a cell becomes committed to become a vestibular receptor cell." [GOC:dph]
synonym: "vestibular hair cell fate commitment" EXACT []
is_a: GO:0060120 ! inner ear receptor cell fate commitment
relationship: part_of GO:0060114 ! vestibular receptor cell differentiation

[Term]
id: GO:0060116
name: vestibular receptor cell morphogenesis
namespace: biological_process
def: "Any process that alters the size or shape of a vestibular receptor cell." [GOC:dph, GOC:tb]
synonym: "vestibular hair cell morphogenesis" EXACT []
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0048667 ! cell morphogenesis involved in neuron differentiation
relationship: part_of GO:0042472 ! inner ear morphogenesis
relationship: part_of GO:0060118 ! vestibular receptor cell development

[Term]
id: GO:0060117
name: auditory receptor cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of an auditory receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph]
synonym: "auditory hair cell development" EXACT []
is_a: GO:0002066 ! columnar/cuboidal epithelial cell development
is_a: GO:0060119 ! inner ear receptor cell development
relationship: part_of GO:0042491 ! auditory receptor cell differentiation

[Term]
id: GO:0060118
name: vestibular receptor cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a vestibular receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph]
synonym: "vestibular hair cell development" EXACT []
is_a: GO:0060119 ! inner ear receptor cell development
relationship: part_of GO:0060114 ! vestibular receptor cell differentiation

[Term]
id: GO:0060119
name: inner ear receptor cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of an inner ear receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph]
synonym: "inner ear hair cell development" EXACT []
is_a: GO:0048666 ! neuron development
relationship: part_of GO:0060113 ! inner ear receptor cell differentiation

[Term]
id: GO:0060120
name: inner ear receptor cell fate commitment
namespace: biological_process
def: "The process in which a cell becomes committed to become an inner ear receptor cell." [GOC:dph]
synonym: "inner ear hair cell fate commitment" EXACT []
is_a: GO:0048663 ! neuron fate commitment
relationship: part_of GO:0060113 ! inner ear receptor cell differentiation

[Term]
id: GO:0060121
name: vestibular receptor cell stereocilium organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of vestibular hair cells." [GOC:dph]
synonym: "vestibular hair cell stereocilium organization" EXACT []
synonym: "vestibular receptor cell stereocilium organisation" EXACT [GOC:mah]
synonym: "vestibular receptor cell stereocilium organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0060122 ! inner ear receptor stereocilium organization
relationship: part_of GO:0060116 ! vestibular receptor cell morphogenesis

[Term]
id: GO:0060122
name: inner ear receptor stereocilium organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of inner ear receptor cells." [GOC:dph]
synonym: "inner ear hair cell receptor stereocilium organization" EXACT []
synonym: "inner ear receptor stereocilium organisation" EXACT [GOC:mah]
synonym: "inner ear receptor stereocilium organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0030030 ! cell projection organization
relationship: part_of GO:0060119 ! inner ear receptor cell development

[Term]
id: GO:0060123
name: regulation of growth hormone secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of growth hormone from a cell." [GOC:dph]
is_a: GO:0090276 ! regulation of peptide hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030252 ! growth hormone secretion
relationship: regulates GO:0030252 ! growth hormone secretion

[Term]
id: GO:0060124
name: positive regulation of growth hormone secretion
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the regulated release of growth hormone from a cell." [GOC:dph]
is_a: GO:0060123 ! regulation of growth hormone secretion
is_a: GO:0090277 ! positive regulation of peptide hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030252 ! growth hormone secretion
relationship: positively_regulates GO:0030252 ! growth hormone secretion

[Term]
id: GO:0060125
name: negative regulation of growth hormone secretion
namespace: biological_process
def: "Any process that decreases or stops the frequency, rate or extent of the regulated release of growth hormone from a cell." [GOC:dph]
is_a: GO:0060123 ! regulation of growth hormone secretion
is_a: GO:0090278 ! negative regulation of peptide hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030252 ! growth hormone secretion
relationship: negatively_regulates GO:0030252 ! growth hormone secretion

[Term]
id: GO:0060126
name: somatotropin secreting cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a somatotropin secreting cell. A somatotropin secreting cell is an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin." [GOC:dph]
synonym: "growth hormone secreting cell differentiation" EXACT []
synonym: "somatotrope differentiation" RELATED []
synonym: "somatotroph differentiation" RELATED []
synonym: "somatotrophin secreting cell differentiation" EXACT []
synonym: "somatotropic cell differentiation" RELATED []
synonym: "somatrophic cell differentiation" RELATED []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0021984 ! adenohypophysis development

[Term]
id: GO:0060127
name: prolactin secreting cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a prolactin secreting cell. A prolactin secreting cell is an acidophilic cell of the anterior pituitary that produces prolactin." [GOC:dph]
synonym: "epsilon-acidophil differentiation" EXACT []
synonym: "lactotrope differentiation" EXACT []
synonym: "lactotroph differentiation" EXACT []
synonym: "lactotropic cell differentiation" EXACT []
synonym: "mammotrope differentiation" EXACT []
synonym: "mammotroph differentiation" EXACT []
synonym: "mammotrophic cell differentiation" EXACT []
synonym: "mammotropic cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0021984 ! adenohypophysis development

[Term]
id: GO:0060128
name: corticotropin hormone secreting cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a corticotropic hormone secreting cell. An corticotropic hormone secreting cell is a basophil cell of the anterior pituitary that produces corticotropin." [GOC:dph]
synonym: "adrenocorticotrophic hormone secreting cell differentiation" EXACT []
synonym: "adrenocorticotropic hormone secreting cell differentiation" EXACT [GOC:dph]
synonym: "corticotrope differentiation" EXACT []
synonym: "corticotroph differentiation" EXACT []
synonym: "corticotrophin hormone secreting cell differentiation" RELATED []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0021984 ! adenohypophysis development

[Term]
id: GO:0060129
name: thyroid-stimulating hormone-secreting cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a thyroid-stimulating hormone-secreting cell. A thyroid-stimulating hormone-secreting cell is a basophil cell of the anterior pituitary that produces thyroid-stimulating hormone, thyrotrophin." [GOC:dph]
synonym: "beta-basophil differentiation" EXACT []
synonym: "thyroid stimulating hormone secreting cell differentiation" EXACT []
synonym: "thyrotrope differentiation" EXACT []
synonym: "thyrotroph differentiation" EXACT []
synonym: "TSH-secreting cell differentiation" EXACT []
is_a: GO:0002067 ! glandular epithelial cell differentiation
is_a: GO:0061101 ! neuroendocrine cell differentiation
relationship: part_of GO:0021984 ! adenohypophysis development

[Term]
id: GO:0060130
name: thyroid-stimulating hormone-secreting cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a thyroid-stimulating hormone-secreting cell over time, from its formation to the mature structure. A thyroid-stimulating hormone-secreting cell is a basophil cell of the anterior pituitary that produces thyroid stimulating hormone, thyrotrophin." [GOC:dph]
synonym: "beta-basophil development" EXACT []
synonym: "thyroid stimulating hormone secreting cell development" EXACT []
synonym: "thyrotrope development" EXACT []
synonym: "thyrotroph development" EXACT []
synonym: "TSH-secreting cell development" EXACT []
is_a: GO:0002068 ! glandular epithelial cell development
relationship: part_of GO:0060129 ! thyroid-stimulating hormone-secreting cell differentiation

[Term]
id: GO:0060131
name: corticotropin hormone secreting cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a corticotropic hormone secreting cell over time, from its formation to the mature structure. An corticotropic hormone secreting cell is a basophil cell of the anterior pituitary that produces corticotropin." [GOC:dph]
synonym: "adrenocorticotrophic hormone secreting cell development" EXACT []
synonym: "adrenocorticotropic hormone secreting cell development" EXACT [GOC:dph]
synonym: "corticotrope development" EXACT []
synonym: "corticotroph development" RELATED []
synonym: "corticotrophin hormone secreting cell development" RELATED []
is_a: GO:0048468 ! cell development
relationship: part_of GO:0060128 ! corticotropin hormone secreting cell differentiation

[Term]
id: GO:0060132
name: prolactin secreting cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a prolactin secreting cell over time, from its formation to the mature structure. A prolactin secreting cell is an acidophilic cell of the anterior pituitary that produces prolactin." [GOC:dph]
synonym: "epsilon-acidophil development" EXACT []
synonym: "lactotrope development" EXACT []
synonym: "lactotroph development" EXACT []
synonym: "lactotropic cell development" EXACT []
synonym: "mammotrope development" EXACT []
synonym: "mammotroph development" EXACT []
synonym: "mammotrophic cell development" EXACT []
synonym: "mammotropic cell development" EXACT []
is_a: GO:0048468 ! cell development
relationship: part_of GO:0060127 ! prolactin secreting cell differentiation

[Term]
id: GO:0060133
name: somatotropin secreting cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a somatotropin secreting cell over time, from its formation to the mature structure. A somatotropin secreting cell is an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin." [GOC:dph]
synonym: "growth hormone secreting cell development" EXACT []
synonym: "somatotrope development" RELATED []
synonym: "somatotroph development" RELATED []
synonym: "somatotrophin secreting cell development" EXACT []
synonym: "somatotropic cell development" EXACT []
synonym: "somatrophic cell development" RELATED []
is_a: GO:0048468 ! cell development
relationship: part_of GO:0060126 ! somatotropin secreting cell differentiation

[Term]
id: GO:0060134
name: prepulse inhibition
namespace: biological_process
def: "The process in which a startle magnitude is reduced when the startling stimulus is preceded by a low-intensity prepulse." [GOC:dph, PMID:10341260]
synonym: "PPI" RELATED []
synonym: "pre-pulse inhibition" EXACT []
xref: Wikipedia:Prepulse_inhibition
is_a: GO:0032102 ! negative regulation of response to external stimulus
relationship: part_of GO:0001964 ! startle response

[Term]
id: GO:0060135
name: maternal process involved in female pregnancy
namespace: biological_process
def: "A reproductive process occurring in the mother that allows an embryo or fetus to develop within it." [GOC:dph]
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0048609 ! multicellular organismal reproductive process
relationship: part_of GO:0007565 ! female pregnancy

[Term]
id: GO:0060136
name: embryonic process involved in female pregnancy
namespace: biological_process
def: "A reproductive process occurring in the embryo or fetus that allows the embryo or fetus to develop within the mother." [GOC:dph]
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0048609 ! multicellular organismal reproductive process
intersection_of: GO:0044702 ! single organism reproductive process
intersection_of: part_of GO:0007565 ! female pregnancy
intersection_of: part_of GO:0009790 ! embryo development
relationship: part_of GO:0007565 ! female pregnancy
relationship: part_of GO:0009790 ! embryo development
relationship: part_of GO:0009792 ! embryo development ending in birth or egg hatching

[Term]
id: GO:0060137
name: maternal process involved in parturition
namespace: biological_process
def: "A reproductive process occurring in the mother that results in birth." [GOC:dph]
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0048609 ! multicellular organismal reproductive process
relationship: part_of GO:0007567 ! parturition

[Term]
id: GO:0060138
name: fetal process involved in parturition
namespace: biological_process
def: "A reproductive process occurring in the embryo that results in birth." [GOC:dph]
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0048609 ! multicellular organismal reproductive process
relationship: part_of GO:0007567 ! parturition
relationship: part_of GO:0009792 ! embryo development ending in birth or egg hatching

[Term]
id: GO:0060139
name: positive regulation of apoptotic process by virus
namespace: biological_process
def: "Any viral process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:dph, GOC:mtg_apoptosis]
synonym: "positive regulation of apoptosis by virus" NARROW []
is_a: GO:0019054 ! modulation by virus of host process
is_a: GO:0052151 ! positive regulation by symbiont of host apoptotic process

[Term]
id: GO:0060140
name: modulation by virus of syncytium formation via plasma membrane fusion
namespace: biological_process
def: "The formation in a cell that has been targeted by a virus of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:dph]
is_a: GO:0060142 ! regulation of syncytium formation by plasma membrane fusion
relationship: part_of GO:0006948 ! induction by virus of host cell-cell fusion

[Term]
id: GO:0060141
name: positive regulation of syncytium formation by virus
namespace: biological_process
def: "The process in which a virus increases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:dph]
synonym: "syncytium formation induced by viral infection" EXACT [UniProtKB-KW:KW-1180]
is_a: GO:0019054 ! modulation by virus of host process
is_a: GO:0060140 ! modulation by virus of syncytium formation via plasma membrane fusion
is_a: GO:0060143 ! positive regulation of syncytium formation by plasma membrane fusion
relationship: part_of GO:0006948 ! induction by virus of host cell-cell fusion

[Term]
id: GO:0060142
name: regulation of syncytium formation by plasma membrane fusion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:dph]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000768 ! syncytium formation by plasma membrane fusion
relationship: regulates GO:0000768 ! syncytium formation by plasma membrane fusion

[Term]
id: GO:0060143
name: positive regulation of syncytium formation by plasma membrane fusion
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:dph]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:0060142 ! regulation of syncytium formation by plasma membrane fusion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000768 ! syncytium formation by plasma membrane fusion
relationship: positively_regulates GO:0000768 ! syncytium formation by plasma membrane fusion

[Term]
id: GO:0060144
name: host cellular process involved in virus induced gene silencing
namespace: biological_process
def: "A cellular process occurring in the host cell that contributes to the process of posttranscriptional gene inactivation ('silencing') both of viral gene(s), and host gene(s) homologous to the viral genes." [GOC:dph]
is_a: GO:0051702 ! interaction with symbiont
relationship: part_of GO:0009616 ! virus induced gene silencing

[Term]
id: GO:0060145
name: viral gene silencing in virus induced gene silencing
namespace: biological_process
def: "The posttranscriptional gene silencing of viral genes after viral infection." [GOC:dph]
is_a: GO:0016441 ! posttranscriptional gene silencing
relationship: part_of GO:0009616 ! virus induced gene silencing

[Term]
id: GO:0060146
name: host gene silencing in virus induced gene silencing
namespace: biological_process
def: "The posttranscriptional gene silencing of host genes that are homologous to viral genes after viral infection." [GOC:dph]
is_a: GO:0016441 ! posttranscriptional gene silencing
relationship: part_of GO:0009616 ! virus induced gene silencing

[Term]
id: GO:0060147
name: regulation of posttranscriptional gene silencing
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the inactivation of gene expression by a posttranscriptional mechanism." [GOC:dph]
is_a: GO:0060968 ! regulation of gene silencing
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016441 ! posttranscriptional gene silencing
relationship: regulates GO:0016441 ! posttranscriptional gene silencing

[Term]
id: GO:0060148
name: positive regulation of posttranscriptional gene silencing
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the inactivation of gene expression by a posttranscriptional mechanism." [GOC:dph]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0060147 ! regulation of posttranscriptional gene silencing
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016441 ! posttranscriptional gene silencing
relationship: positively_regulates GO:0016441 ! posttranscriptional gene silencing

[Term]
id: GO:0060149
name: negative regulation of posttranscriptional gene silencing
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the inactivation of gene expression by a posttranscriptional mechanism." [GOC:dph]
is_a: GO:0060147 ! regulation of posttranscriptional gene silencing
is_a: GO:0060969 ! negative regulation of gene silencing
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016441 ! posttranscriptional gene silencing
relationship: negatively_regulates GO:0016441 ! posttranscriptional gene silencing

[Term]
id: GO:0060150
name: viral triggering of virus induced gene silencing
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the inactivation of gene expression of both viral genes and host homologues to those genes by a posttranscriptional mechanism in a virally infected cell." [GOC:dph]
is_a: GO:0060148 ! positive regulation of posttranscriptional gene silencing
relationship: part_of GO:0009616 ! virus induced gene silencing

[Term]
id: GO:0060151
name: peroxisome localization
namespace: biological_process
def: "Any process in which a peroxisome is transported to, and/or maintained in, a specific location. A peroxisome is a small membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:dph, PMID:16449325]
synonym: "peroxisome localisation" EXACT [GOC:mah]
is_a: GO:0051640 ! organelle localization

[Term]
id: GO:0060152
name: microtubule-based peroxisome localization
namespace: biological_process
def: "The microtubule-based process in which a peroxisome is transported to, and/or maintained in, a specific location. A peroxisome is a small membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:dph, PMID:16449325]
synonym: "microtubule-based peroxisome localisation" EXACT [GOC:mah]
is_a: GO:0007017 ! microtubule-based process
is_a: GO:0060151 ! peroxisome localization
is_a: GO:1902580 ! single-organism cellular localization

[Term]
id: GO:0060153
name: modulation by virus of host cell cycle
namespace: biological_process
def: "Any viral process that modulates the rate or extent of progression through the cell cycle." [GOC:dph, UniProtKB-KW:KW-1121, VZ:1636]
subset: goslim_virus
synonym: "modulation of host cell cycle by virus" EXACT [UniProtKB-KW:KW-1121]
synonym: "regulation by virus of host cell cycle" EXACT []
synonym: "regulation of host cell cycle by virus" EXACT []
synonym: "viral process regulating host cell cycle" EXACT []
xref: VZ:1636 "Modulation of host cell cycle by virus"
is_a: GO:0019054 ! modulation by virus of host process
is_a: GO:0044071 ! modulation by symbiont of host cell cycle

[Term]
id: GO:0060154
name: cellular process regulating host cell cycle in response to virus
namespace: biological_process
def: "Any cellular process that modulates the rate or extent of progression through the cell cycle in response to a virus." [GOC:dph]
is_a: GO:0051726 ! regulation of cell cycle
is_a: GO:0098586 ! cellular response to virus

[Term]
id: GO:0060155
name: platelet dense granule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a platelet dense granule. A platelet dense granule is an electron-dense granule occurring in blood platelets that stores and secretes adenosine nucleotides and serotonin. They contain a highly condensed core consisting of serotonin, histamine, calcium, magnesium, ATP, ADP, pyrophosphate and membrane lysosomal proteins." [GOC:dph, PMID:11487378]
synonym: "bull's eye body organization and biogenesis" RELATED []
synonym: "platelet dense body organization and biogenesis" RELATED []
synonym: "platelet dense granule organisation" EXACT [GOC:mah]
synonym: "platelet dense granule organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0033363 ! secretory granule organization

[Term]
id: GO:0060156
name: milk ejection
namespace: biological_process
def: "An automatic response to suckling, beginning with a nerve impulse from a receptor in the mammary gland and ending with the ejection of milk from the gland. Signaling never reaches a level of consciousness." [GOC:dph, GOC:mr, GOC:st]
is_a: GO:0060004 ! reflex

[Term]
id: GO:0060157
name: urinary bladder development
namespace: biological_process
def: "The process whose specific outcome is the progression of the urinary bladder over time, from its formation to the mature structure. The urinary bladder is an elastic, muscular sac situated in the anterior part of the pelvic cavity in which urine collects before excretion." [GOC:dph, GOC:ln, GOC:mr, http://en.wikipedia.org/wiki/Rhea_(bird), PMID:11768524, PMID:18276178, PMID:538956]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048513 ! animal organ development
relationship: part_of GO:0072001 ! renal system development

[Term]
id: GO:0060158
name: phospholipase C-activating dopamine receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:dph, GOC:signaling, GOC:tb, PMID:12675914]
synonym: "activation of phospholipase C activity by dopamine receptor signaling pathway" RELATED [GOC:signaling]
synonym: "activation of phospholipase C activity by dopamine receptor signalling pathway" RELATED [GOC:mah]
synonym: "dopamine receptor, phospholipase C activating pathway" RELATED [GOC:dph, GOC:tb]
is_a: GO:0007200 ! phospholipase C-activating G-protein coupled receptor signaling pathway
is_a: GO:0007212 ! dopamine receptor signaling pathway

[Term]
id: GO:0060159
name: regulation of dopamine receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a dopamine receptor signaling pathway activity. A dopamine receptor signaling pathway is the series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands." [GOC:dph]
synonym: "regulation of dopamine receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007212 ! dopamine receptor signaling pathway
relationship: regulates GO:0007212 ! dopamine receptor signaling pathway

[Term]
id: GO:0060160
name: negative regulation of dopamine receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of dopamine receptor protein signaling pathway activity. A dopamine receptor signaling pathway is the series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands." [GOC:dph]
synonym: "negative regulation of dopamine receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0045744 ! negative regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:0060159 ! regulation of dopamine receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007212 ! dopamine receptor signaling pathway
relationship: negatively_regulates GO:0007212 ! dopamine receptor signaling pathway

[Term]
id: GO:0060161
name: positive regulation of dopamine receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the dopamine receptor protein signaling pathway. A dopamine receptor signaling pathway is the series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands." [GOC:dph]
synonym: "positive regulation of dopamine receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0045745 ! positive regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:0060159 ! regulation of dopamine receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007212 ! dopamine receptor signaling pathway
relationship: positively_regulates GO:0007212 ! dopamine receptor signaling pathway

[Term]
id: GO:0060162
name: negative regulation of phospholipase C-activating dopamine receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the dopamine receptor, phospholipase C activating pathway." [GOC:dph, GOC:tb, PMID:15016423]
synonym: "negative regulation of dopamine receptor, phospholipase C activating pathway" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of phospholipase C-activating dopamine receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0060160 ! negative regulation of dopamine receptor signaling pathway
is_a: GO:1900737 ! negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060158 ! phospholipase C-activating dopamine receptor signaling pathway
relationship: negatively_regulates GO:0060158 ! phospholipase C-activating dopamine receptor signaling pathway

[Term]
id: GO:0060163
name: subpallium neuron fate commitment
namespace: biological_process
def: "The process in which in the subpallium, the developmental fate of a cell becomes restricted such that it will develop into a neuron. The subpallium is the base region of the telencephalon." [GOC:dph]
synonym: "subpallium neuronal precursor fate commitment" RELATED []
is_a: GO:0048663 ! neuron fate commitment
relationship: part_of GO:0021544 ! subpallium development

[Term]
id: GO:0060164
name: regulation of timing of neuron differentiation
namespace: biological_process
def: "The process controlling the activation and/or rate at which a relatively unspecialized cell acquires features of a neuron." [GOC:dph]
is_a: GO:0045664 ! regulation of neuron differentiation
is_a: GO:0048505 ! regulation of timing of cell differentiation

[Term]
id: GO:0060165
name: regulation of timing of subpallium neuron differentiation
namespace: biological_process
def: "The process controlling the timing and/or rate at which a relatively unspecialized cell in the subpallium acquires features of a neuron. The subpallium is the base region of the telencephalon." [GOC:dph]
is_a: GO:0060164 ! regulation of timing of neuron differentiation
relationship: part_of GO:0021544 ! subpallium development

[Term]
id: GO:0060166
name: olfactory pit development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of the olfactory pit from an initial condition to its mature state. This process begins with the formation of the olfactory pit, which is an indentation of the olfactory placode, and ends when the pits hollows out to form the nasopharynx." [GOC:dph, ISBN:0124020607]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0043584 ! nose development

[Term]
id: GO:0060167
name: regulation of adenosine receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the adenosine receptor signaling pathway. The adenosine receptor pathway is the series of molecular signals generated as a consequence of an adenosine receptor binding to one of its physiological ligands." [GOC:dph]
synonym: "regulation of adenosine receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001973 ! adenosine receptor signaling pathway
relationship: regulates GO:0001973 ! adenosine receptor signaling pathway

[Term]
id: GO:0060168
name: positive regulation of adenosine receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the adenosine receptor signaling pathway. The adenosine receptor pathway is the series of molecular signals generated as a consequence of an adenosine receptor binding to one of its physiological ligands." [GOC:dph]
synonym: "positive regulation of adenosine receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0045745 ! positive regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:0060167 ! regulation of adenosine receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001973 ! adenosine receptor signaling pathway
relationship: positively_regulates GO:0001973 ! adenosine receptor signaling pathway

[Term]
id: GO:0060169
name: negative regulation of adenosine receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the adenosine receptor signaling pathway. The adenosine receptor pathway is the series of molecular signals generated as a consequence of an adenosine receptor binding to one of its physiological ligands." [GOC:dph]
synonym: "negative regulation of adenosine receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0045744 ! negative regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:0060167 ! regulation of adenosine receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001973 ! adenosine receptor signaling pathway
relationship: negatively_regulates GO:0001973 ! adenosine receptor signaling pathway

[Term]
id: GO:0060170
name: ciliary membrane
namespace: cellular_component
alt_id: GO:0020017
def: "The portion of the plasma membrane surrounding a cilium." [GOC:cilia, GOC:dph, GOC:rph]
comment: Note that cilia and eukaryotic flagella are deemed to be equivalent.
synonym: "cilial membrane" EXACT []
synonym: "cilium membrane" EXACT []
synonym: "flagellar membrane" NARROW []
synonym: "flagellum membrane" NARROW []
is_a: GO:0031253 ! cell projection membrane
is_a: GO:0044441 ! ciliary part
is_a: GO:0098588 ! bounding membrane of organelle
relationship: part_of GO:0005886 ! plasma membrane

[Term]
id: GO:0060171
name: stereocilium membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a stereocilium." [GOC:dph, GOC:rph]
is_a: GO:0031253 ! cell projection membrane
is_a: GO:0044422 ! organelle part
is_a: GO:0044424 ! intracellular part
is_a: GO:0097458 ! neuron part
relationship: part_of GO:0032420 ! stereocilium

[Term]
id: GO:0060172
name: astral microtubule depolymerization
namespace: biological_process
def: "The removal of tubulin heterodimers from one or both ends of an astral microtubule. An astral microtubule is any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell." [GOC:dph]
is_a: GO:0007019 ! microtubule depolymerization
is_a: GO:0030953 ! astral microtubule organization

[Term]
id: GO:0060173
name: limb development
namespace: biological_process
def: "The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin." [GOC:dgh, GOC:dph, PMID:11487378]
synonym: "limb bud development" NARROW [GOC:dph]
xref: Wikipedia:Limb_development
is_a: GO:0048736 ! appendage development

[Term]
id: GO:0060174
name: limb bud formation
namespace: biological_process
def: "The process pertaining to the initial formation of a limb bud from unspecified parts. This process begins with the formation of a local condensation of mesenchyme cells within the prospective limb field, and ends when a limb bud is recognizable." [GOC:dgh, GOC:dph]
synonym: "limb formation" EXACT []
synonym: "limbbud formation" EXACT []
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0035108 ! limb morphogenesis

[Term]
id: GO:0060175
name: brain-derived neurotrophic factor-activated receptor activity
namespace: molecular_function
def: "Combining with a brain-derived neurotrophic factor and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:bf, GOC:dph]
comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand BDNF. For receptors that bind other growth factors, consider annotating to other terms under 'transmembrane signaling receptor activity ; GO:0004888.
synonym: "BDNF receptor activity" RELATED [GOC:dph]
synonym: "BDNF-activated receptor activity" EXACT [GOC:bf, GOC:signaling]
synonym: "brain-derived neurotrophic factor receptor activity" EXACT [GOC:bf, GOC:signaling]
is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity
is_a: GO:0005030 ! neurotrophin receptor activity
relationship: has_part GO:0048403 ! brain-derived neurotrophic factor binding
relationship: part_of GO:0031547 ! brain-derived neurotrophic factor receptor signaling pathway

[Term]
id: GO:0060176
name: regulation of aggregation involved in sorocarp development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of aggregation during sorocarp development. Aggregation involved in sorocarp development is the process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug." [GOC:dph, GOC:tb]
is_a: GO:0031156 ! regulation of sorocarp development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031152 ! aggregation involved in sorocarp development
relationship: regulates GO:0031152 ! aggregation involved in sorocarp development

[Term]
id: GO:0060177
name: regulation of angiotensin metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving angiotensin." [GOC:dph, GOC:tb]
synonym: "regulation of angiotensin metabolism" EXACT []
is_a: GO:0051246 ! regulation of protein metabolic process

[Term]
id: GO:0060178
name: regulation of exocyst localization
namespace: biological_process
def: "Any process that modulates the localization of exocysts. An exocyst is a protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse." [GOC:dph, GOC:tb]
synonym: "regulation of exocyst localisation" EXACT [GOC:mah]
is_a: GO:1903827 ! regulation of cellular protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051601 ! exocyst localization
relationship: regulates GO:0051601 ! exocyst localization

[Term]
id: GO:0060179
name: male mating behavior
namespace: biological_process
def: "The specific behavior of a male organism that is associated with reproduction." [GOC:dph, GOC:pr, GOC:tb]
is_a: GO:0007617 ! mating behavior

[Term]
id: GO:0060180
name: female mating behavior
namespace: biological_process
def: "The specific behavior of a female organism that is associated with reproduction." [GOC:dph, GOC:pr, GOC:tb]
is_a: GO:0007617 ! mating behavior

[Term]
id: GO:0060182
name: apelin receptor activity
namespace: molecular_function
def: "Combining with the peptide apelin to initiate a change in cell activity." [GOC:dph]
is_a: GO:0008528 ! G-protein coupled peptide receptor activity
relationship: part_of GO:0060183 ! apelin receptor signaling pathway

[Term]
id: GO:0060183
name: apelin receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of an apelin receptor binding to one of its physiological ligands." [GOC:dph]
synonym: "apelin receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0007186 ! G-protein coupled receptor signaling pathway

[Term]
id: GO:0060184
name: cell cycle switching
namespace: biological_process
def: "The process in which a cell switches cell cycle mode." [GOC:dph, GOC:kmv, GOC:tb]
is_a: GO:0022402 ! cell cycle process

[Term]
id: GO:0060185
name: outer ear unfolding
namespace: biological_process
def: "The opening and spreading out of the outer ear." [GOC:dph]
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0042473 ! outer ear morphogenesis

[Term]
id: GO:0060186
name: outer ear emergence
namespace: biological_process
def: "The growth of the outer ear." [GOC:dph]
synonym: "ear elevation" RELATED [GOC:dph]
synonym: "ear extroversion" RELATED [GOC:dph]
synonym: "outer ear growth" RELATED [GOC:dph]
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0042473 ! outer ear morphogenesis

[Term]
id: GO:0060187
name: cell pole
namespace: cellular_component
def: "Either of two different areas at opposite ends of an axis of a cell." [GOC:dph]
comment: Note that this term differs from 'cell tip ; GO:0051286' in that it is applicable to a broad range of cell shapes including spherical and cuboidal.
is_a: GO:0044464 ! cell part

[Term]
id: GO:0060188
name: regulation of protein desumoylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein desumoylation. Protein desumoylation is the process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein." [GOC:dph, GOC:tb]
is_a: GO:0030162 ! regulation of proteolysis
is_a: GO:1903320 ! regulation of protein modification by small protein conjugation or removal
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016926 ! protein desumoylation
relationship: regulates GO:0016926 ! protein desumoylation

[Term]
id: GO:0060189
name: positive regulation of protein desumoylation
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of protein desumoylation. Protein desumoylation is the process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein." [GOC:dph, GOC:tb]
is_a: GO:0045862 ! positive regulation of proteolysis
is_a: GO:0060188 ! regulation of protein desumoylation
is_a: GO:1903322 ! positive regulation of protein modification by small protein conjugation or removal
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016926 ! protein desumoylation
relationship: positively_regulates GO:0016926 ! protein desumoylation

[Term]
id: GO:0060190
name: negative regulation of protein desumoylation
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of protein desumoylation. Protein desumoylation is the process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein." [GOC:dph, GOC:tb]
is_a: GO:0045861 ! negative regulation of proteolysis
is_a: GO:0060188 ! regulation of protein desumoylation
is_a: GO:1903321 ! negative regulation of protein modification by small protein conjugation or removal
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016926 ! protein desumoylation
relationship: negatively_regulates GO:0016926 ! protein desumoylation

[Term]
id: GO:0060191
name: regulation of lipase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid." [GOC:dph, GOC:tb]
subset: gosubset_prok
is_a: GO:0051336 ! regulation of hydrolase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016298 ! lipase activity
relationship: regulates GO:0016298 ! lipase activity

[Term]
id: GO:0060192
name: negative regulation of lipase activity
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid." [GOC:dph, GOC:tb]
is_a: GO:0051346 ! negative regulation of hydrolase activity
is_a: GO:0060191 ! regulation of lipase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016298 ! lipase activity
relationship: negatively_regulates GO:0016298 ! lipase activity

[Term]
id: GO:0060193
name: positive regulation of lipase activity
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0051345 ! positive regulation of hydrolase activity
is_a: GO:0060191 ! regulation of lipase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016298 ! lipase activity
relationship: positively_regulates GO:0016298 ! lipase activity

[Term]
id: GO:0060194
name: regulation of antisense RNA transcription
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the synthesis of antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis, on a template of DNA." [GOC:dph, GOC:jp, GOC:tb, PMID:18075583]
is_a: GO:0006355 ! regulation of transcription, DNA-templated
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009300 ! antisense RNA transcription
relationship: regulates GO:0009300 ! antisense RNA transcription

[Term]
id: GO:0060195
name: negative regulation of antisense RNA transcription
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the synthesis of antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis, on a template of DNA." [GOC:dph, GOC:tb, PMID:18075583]
is_a: GO:0045892 ! negative regulation of transcription, DNA-templated
is_a: GO:0060194 ! regulation of antisense RNA transcription
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009300 ! antisense RNA transcription
relationship: negatively_regulates GO:0009300 ! antisense RNA transcription

[Term]
id: GO:0060196
name: positive regulation of antisense RNA transcription
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the synthesis of antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis, on a template of DNA." [GOC:dph, GOC:tb, PMID:18075583]
is_a: GO:0045893 ! positive regulation of transcription, DNA-templated
is_a: GO:0060194 ! regulation of antisense RNA transcription
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009300 ! antisense RNA transcription
relationship: positively_regulates GO:0009300 ! antisense RNA transcription

[Term]
id: GO:0060197
name: cloacal septation
namespace: biological_process
def: "The separation of the single opening of the digestive, urinary, and reproductive tracts, the cloaca, into multiple isolated openings during development." [GOC:dph, GOC:st]
synonym: "cloaca septation" EXACT [GOC:cjm]
is_a: GO:0035239 ! tube morphogenesis
relationship: part_of GO:0035844 ! cloaca development

[Term]
id: GO:0060198
name: clathrin-sculpted vesicle
namespace: cellular_component
def: "A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release." [GOC:dph]
synonym: "clathrin sculpted vesicle" EXACT [GOC:sl]
is_a: GO:0030136 ! clathrin-coated vesicle

[Term]
id: GO:0060199
name: clathrin-sculpted glutamate transport vesicle
namespace: cellular_component
def: "A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing glutamate." [GOC:dph]
synonym: "clathrin sculpted glutamate constitutive secretory pathway transport vesicle" EXACT []
synonym: "clathrin sculpted glutamate transport vesicle" EXACT [GOC:sl]
is_a: GO:0030133 ! transport vesicle
is_a: GO:0060198 ! clathrin-sculpted vesicle

[Term]
id: GO:0060200
name: clathrin-sculpted acetylcholine transport vesicle
namespace: cellular_component
def: "A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing acetylcholine." [GOC:dph]
synonym: "clathrin sculpted acetylcholine constitutive secretory pathway transport vesicle" EXACT []
synonym: "clathrin sculpted acetylcholine transport vesicle" EXACT [GOC:sl]
is_a: GO:0030133 ! transport vesicle
is_a: GO:0060198 ! clathrin-sculpted vesicle

[Term]
id: GO:0060201
name: clathrin-sculpted acetylcholine transport vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a clathrin-sculpted acetylcholine transport vesicle." [GOC:dph]
synonym: "clathrin sculpted acetylcholine constitutive secretory pathway transport vesicle membrane" EXACT []
synonym: "clathrin sculpted acetylcholine transport vesicle membrane" EXACT [GOC:sl]
is_a: GO:0030658 ! transport vesicle membrane
is_a: GO:0030665 ! clathrin-coated vesicle membrane
relationship: part_of GO:0060200 ! clathrin-sculpted acetylcholine transport vesicle

[Term]
id: GO:0060202
name: clathrin-sculpted acetylcholine transport vesicle lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of the clathrin-sculpted acetylcholine transport vesicle." [GOC:dph]
synonym: "clathrin sculpted acetylcholine constitutive secretory pathway transport vesicle lumen" EXACT []
synonym: "clathrin sculpted acetylcholine transport vesicle lumen" EXACT [GOC:sl]
is_a: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen
relationship: part_of GO:0060200 ! clathrin-sculpted acetylcholine transport vesicle

[Term]
id: GO:0060203
name: clathrin-sculpted glutamate transport vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a clathrin-sculpted glutamate transport vesicle." [GOC:dph]
synonym: "clathrin sculpted glutamate constitutive secretory pathway transport vesicle membrane" EXACT []
synonym: "clathrin sculpted glutamate transport vesicle membrane" EXACT [GOC:sl]
is_a: GO:0030658 ! transport vesicle membrane
is_a: GO:0030665 ! clathrin-coated vesicle membrane
relationship: part_of GO:0060199 ! clathrin-sculpted glutamate transport vesicle

[Term]
id: GO:0060204
name: clathrin-sculpted glutamate transport vesicle lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of the clathrin-sculpted glutamate transport vesicle." [GOC:dph]
synonym: "clathrin sculpted glutamate constitutive secretory pathway transport vesicle lumen" EXACT []
synonym: "clathrin sculpted glutamate transport vesicle lumen" EXACT [GOC:sl]
is_a: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen
relationship: part_of GO:0060199 ! clathrin-sculpted glutamate transport vesicle

[Term]
id: GO:0060205
name: cytoplasmic membrane-bounded vesicle lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of a cytoplasmic membrane-bounded vesicle." [GOC:dph]
synonym: "cytoplasmic membrane-enclosed vesicle lumen" EXACT []
is_a: GO:0031983 ! vesicle lumen
is_a: GO:0044433 ! cytoplasmic vesicle part
relationship: part_of GO:0016023 ! cytoplasmic, membrane-bounded vesicle

[Term]
id: GO:0060206
name: estrous cycle phase
namespace: biological_process
def: "The progression of physiological phases, occurring in the endometrium during the estrous cycle that recur at regular intervals during the reproductive years. The estrous cycle is an ovulation cycle where the endometrium is resorbed if pregnancy does not occur." [GOC:dph]
subset: gocheck_do_not_annotate
is_a: GO:0044848 ! biological phase

[Term]
id: GO:0060207
name: diestrus
namespace: biological_process
def: "The estrous cycle phase which is a period of sexual quiescence and represents the phase of the mature corpus luteum." [GOC:dph, ISBN:0721662544]
subset: gocheck_do_not_annotate
is_a: GO:0060206 ! estrous cycle phase

[Term]
id: GO:0060208
name: proestrus
namespace: biological_process
def: "The estrous cycle phase in which there is heightened follicular activity." [GOC:dph, ISBN:0721662544]
subset: gocheck_do_not_annotate
is_a: GO:0060206 ! estrous cycle phase

[Term]
id: GO:0060209
name: estrus
namespace: biological_process
def: "The estrous cycle phase in which a female is sexually receptive." [GOC:dph, ISBN:0721662544]
subset: gocheck_do_not_annotate
synonym: "oestrus" EXACT []
is_a: GO:0060206 ! estrous cycle phase

[Term]
id: GO:0060210
name: metestrus
namespace: biological_process
def: "The estrous cycle phase in which there is subsiding follicular function." [GOC:dph, ISBN:0721662544]
subset: gocheck_do_not_annotate
is_a: GO:0060206 ! estrous cycle phase

[Term]
id: GO:0060211
name: regulation of nuclear-transcribed mRNA poly(A) tail shortening
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length." [GOC:dph, GOC:tb]
synonym: "regulation of 3' to 5' mRNA deadenylation" RELATED []
synonym: "regulation of mRNA deadenylation" RELATED []
synonym: "regulation of nuclear mRNA poly(A) tail shortening" RELATED []
is_a: GO:0031440 ! regulation of mRNA 3'-end processing
is_a: GO:1900151 ! regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000289 ! nuclear-transcribed mRNA poly(A) tail shortening
relationship: regulates GO:0000289 ! nuclear-transcribed mRNA poly(A) tail shortening

[Term]
id: GO:0060212
name: negative regulation of nuclear-transcribed mRNA poly(A) tail shortening
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length." [GOC:dph, GOC:tb]
synonym: "negative regulation of 3' to 5' mRNA deadenylation" RELATED [GOC:dph, GOC:tb]
synonym: "negative regulation of mRNA deadenylation" RELATED [GOC:dph, GOC:tb]
synonym: "negative regulation of nuclear mRNA poly(A) tail shortening" RELATED []
is_a: GO:0031441 ! negative regulation of mRNA 3'-end processing
is_a: GO:0060211 ! regulation of nuclear-transcribed mRNA poly(A) tail shortening
is_a: GO:1900152 ! negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000289 ! nuclear-transcribed mRNA poly(A) tail shortening
relationship: negatively_regulates GO:0000289 ! nuclear-transcribed mRNA poly(A) tail shortening

[Term]
id: GO:0060213
name: positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length." [GOC:dph, GOC:tb]
synonym: "positive regulation of 3' to 5' mRNA deadenylation" RELATED [GOC:dph, GOC:tb]
synonym: "positive regulation of mRNA deadenylation" RELATED [GOC:dph, GOC:tb]
synonym: "positive regulation of nuclear mRNA poly(A) tail shortening" RELATED []
is_a: GO:0031442 ! positive regulation of mRNA 3'-end processing
is_a: GO:0060211 ! regulation of nuclear-transcribed mRNA poly(A) tail shortening
is_a: GO:1900153 ! positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000289 ! nuclear-transcribed mRNA poly(A) tail shortening
relationship: positively_regulates GO:0000289 ! nuclear-transcribed mRNA poly(A) tail shortening

[Term]
id: GO:0060214
name: endocardium formation
namespace: biological_process
def: "Formation of the endocardium of the heart. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:bf, GOC:dph, PMID:17722983]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0003160 ! endocardium morphogenesis

[Term]
id: GO:0060215
name: primitive hemopoiesis
namespace: biological_process
def: "A first transient wave of blood cell production that, in vertebrates, gives rise to erythrocytes (red blood cells) and myeloid cells." [GOC:bf, GOC:dph, PMID:15378083, PMID:15617691]
synonym: "primitive haematopoiesis" EXACT []
synonym: "primitive haemopoiesis" EXACT []
synonym: "primitive hematopoiesis" RELATED []
is_a: GO:0035162 ! embryonic hemopoiesis

[Term]
id: GO:0060216
name: definitive hemopoiesis
namespace: biological_process
def: "A second wave of blood cell production that, in vertebrates, generates long-term hemopoietic stem cells that continously provide erythroid, myeloid and lymphoid lineages throughout adulthood." [GOC:bf, GOC:dph, PMID:15378083, PMID:15617691]
synonym: "definitive haematopoiesis" RELATED []
synonym: "definitive haemopoiesis" EXACT []
synonym: "definitive hematopoiesis" EXACT []
is_a: GO:0030097 ! hemopoiesis

[Term]
id: GO:0060217
name: hemangioblast cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the characteristics of a mature hemangioblast. Hemangioblasts are the proposed common precursor of blood and endothelial lineages." [GOC:bf, GOC:dph, PMID:15378083, PMID:9670018]
is_a: GO:0048333 ! mesodermal cell differentiation
relationship: part_of GO:0060215 ! primitive hemopoiesis

[Term]
id: GO:0060218
name: hematopoietic stem cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:bf, GOC:BHF, GOC:dph, GOC:rl, PMID:15378083]
synonym: "haematopoietic stem cell differentiation" EXACT []
synonym: "haemopoietic stem cell differentiation" EXACT []
synonym: "hemopoietic stem cell differentiation" EXACT []
is_a: GO:0002244 ! hematopoietic progenitor cell differentiation
is_a: GO:0048863 ! stem cell differentiation
relationship: part_of GO:0030097 ! hemopoiesis

[Term]
id: GO:0060219
name: camera-type eye photoreceptor cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell in a camera-type eye." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0001754 ! eye photoreceptor cell differentiation
relationship: part_of GO:0003407 ! neural retina development
relationship: part_of GO:0060042 ! retina morphogenesis in camera-type eye

[Term]
id: GO:0060220
name: camera-type eye photoreceptor cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a photoreceptor cell in a camera-type eye." [GOC:dph]
is_a: GO:0042706 ! eye photoreceptor cell fate commitment
relationship: part_of GO:0060219 ! camera-type eye photoreceptor cell differentiation

[Term]
id: GO:0060221
name: retinal rod cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a retinal rod cell." [GOC:dph]
is_a: GO:0060219 ! camera-type eye photoreceptor cell differentiation

[Term]
id: GO:0060222
name: regulation of retinal cone cell fate commitment
namespace: biological_process
def: "Any process that modulates the process in which a cell becomes committed to a retinal cone cell fate. Retinal cone cell fate commitment is the process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal cone cell." [GOC:dph]
is_a: GO:0010453 ! regulation of cell fate commitment
is_a: GO:0046532 ! regulation of photoreceptor cell differentiation
is_a: GO:0061074 ! regulation of neural retina development
is_a: GO:2000027 ! regulation of organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0046551 ! retinal cone cell fate commitment
relationship: regulates GO:0046551 ! retinal cone cell fate commitment

[Term]
id: GO:0060223
name: retinal rod cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal rod cell. A retinal rod cell is one of the two photoreceptor subtypes in a camera-type eye." [GOC:dph]
is_a: GO:0060220 ! camera-type eye photoreceptor cell fate commitment
relationship: part_of GO:0060221 ! retinal rod cell differentiation

[Term]
id: GO:0060224
name: regulation of retinal rod cell fate commitment
namespace: biological_process
def: "Any process that modulates the process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal rod cell. A retinal rod cell is one of the two photoreceptor subtypes in a camera-type eye." [GOC:dph]
is_a: GO:0010453 ! regulation of cell fate commitment
is_a: GO:0046532 ! regulation of photoreceptor cell differentiation
is_a: GO:0061074 ! regulation of neural retina development
is_a: GO:2000027 ! regulation of organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060223 ! retinal rod cell fate commitment
relationship: regulates GO:0060223 ! retinal rod cell fate commitment

[Term]
id: GO:0060225
name: positive regulation of retinal rod cell fate commitment
namespace: biological_process
def: "Any process that increases the process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal rod cell. A retinal rod cell is one of the two photoreceptor subtypes in a camera-type eye." [GOC:dph]
is_a: GO:0010455 ! positive regulation of cell fate commitment
is_a: GO:0046534 ! positive regulation of photoreceptor cell differentiation
is_a: GO:0060224 ! regulation of retinal rod cell fate commitment
is_a: GO:0061075 ! positive regulation of neural retina development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060223 ! retinal rod cell fate commitment
relationship: positively_regulates GO:0060223 ! retinal rod cell fate commitment

[Term]
id: GO:0060226
name: negative regulation of retinal cone cell fate commitment
namespace: biological_process
def: "Any process that increases the process in which a cell becomes committed to a retinal cone cell fate. Retinal cone cell fate commitment is the process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal cone cell." [GOC:dph]
is_a: GO:0010454 ! negative regulation of cell fate commitment
is_a: GO:0046533 ! negative regulation of photoreceptor cell differentiation
is_a: GO:0060222 ! regulation of retinal cone cell fate commitment
is_a: GO:0061076 ! negative regulation of neural retina development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0046551 ! retinal cone cell fate commitment
relationship: negatively_regulates GO:0046551 ! retinal cone cell fate commitment

[Term]
id: GO:0060227
name: Notch signaling pathway involved in camera-type eye photoreceptor fate commitment
namespace: biological_process
def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to the commitment of a precursor cell to a eye photoreceptor fate." [GOC:dph]
synonym: "Notch signalling pathway involved in camera-type eye photoreceptor fate commitment" EXACT [GOC:mah]
is_a: GO:0007219 ! Notch signaling pathway
intersection_of: GO:0007219 ! Notch signaling pathway
intersection_of: part_of GO:0060220 ! camera-type eye photoreceptor cell fate commitment
relationship: part_of GO:0060220 ! camera-type eye photoreceptor cell fate commitment

[Term]
id: GO:0060228
name: phosphatidylcholine-sterol O-acyltransferase activator activity
namespace: molecular_function
def: "Increases the activity of phosphatidylcholine-sterol O-acyltransferase, an enzyme that converts cholesterol and phosphatidylcholine (lecithins) to cholesteryl esters and lyso-phosphatidylcholines." [GOC:BHF, GOC:dph, GOC:tb, PMID:4335615]
synonym: "LCAT activator activity" NARROW [GOC:tb]
is_a: GO:0008047 ! enzyme activator activity
relationship: positively_regulates GO:0004607 ! phosphatidylcholine-sterol O-acyltransferase activity

[Term]
id: GO:0060229
name: lipase activator activity
namespace: molecular_function
def: "Binds to and increases the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0008047 ! enzyme activator activity
relationship: positively_regulates GO:0016298 ! lipase activity

[Term]
id: GO:0060230
name: lipoprotein lipase activator activity
namespace: molecular_function
def: "Binds to and increases the activity of a lipoprotein lipase, an enzyme that catalyzes of the hydrolysis of a lipid within a lipoprotein." [GOC:BHF, GOC:dph, GOC:tb, PMID:10727238]
is_a: GO:0060229 ! lipase activator activity
relationship: positively_regulates GO:0004465 ! lipoprotein lipase activity

[Term]
id: GO:0060231
name: mesenchymal to epithelial transition
namespace: biological_process
def: "A transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "mesenchymal-epithelial transition" EXACT [GOC:dph]
is_a: GO:0003382 ! epithelial cell morphogenesis

[Term]
id: GO:0060232
name: delamination
namespace: biological_process
def: "The process of negative regulation of cell adhesion that results in a cell or sheet of cells splitting off from an existing epithelial sheet." [GOC:dph, PMID:16962574, PMID:18343170]
is_a: GO:0022408 ! negative regulation of cell-cell adhesion

[Term]
id: GO:0060233
name: oenocyte delamination
namespace: biological_process
def: "The negative regulation of cell adhesion process in which an oenocyte splits off of an existing epithelial sheet." [GOC:dph]
is_a: GO:0060232 ! delamination

[Term]
id: GO:0060234
name: neuroblast delamination
namespace: biological_process
def: "The negative regulation of cell adhesion process in which a neuroblast splits off of a neurectodermal sheet." [GOC:dph]
is_a: GO:0060232 ! delamination

[Term]
id: GO:0060235
name: lens induction in camera-type eye
namespace: biological_process
def: "Signaling at short range between the head ectoderm and the optic vesicle that results in the head ectoderm forming a lens." [GOC:dph, ISBN:0878932437]
is_a: GO:0031128 ! developmental induction
relationship: part_of GO:0002089 ! lens morphogenesis in camera-type eye

[Term]
id: GO:0060236
name: regulation of mitotic spindle organization
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "regulation of mitotic spindle organisation" EXACT [GOC:mah]
synonym: "regulation of mitotic spindle organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0007346 ! regulation of mitotic cell cycle
is_a: GO:0090224 ! regulation of spindle organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007052 ! mitotic spindle organization
relationship: regulates GO:0007052 ! mitotic spindle organization

[Term]
id: GO:0060237
name: regulation of fungal-type cell wall organization
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the formation, arrangement of constituent parts, or disassembly of the fungal-type cell wall." [GOC:dph, GOC:tb]
synonym: "regulation of fungal-type cell wall organisation" EXACT [GOC:mah]
synonym: "regulation of fungal-type cell wall organization and biogenesis" RELATED []
is_a: GO:0051128 ! regulation of cellular component organization
is_a: GO:1903338 ! regulation of cell wall organization or biogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031505 ! fungal-type cell wall organization
relationship: regulates GO:0031505 ! fungal-type cell wall organization

[Term]
id: GO:0060238
name: regulation of signal transduction involved in conjugation with cellular fusion
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of pheromone-dependent signal transduction during conjugation with cellular fusion, the series of molecular signals that bring about the relay, amplification or dampening of a signal generated in response to a cue, such as starvation or pheromone exposure, in organisms that undergo conjugation with cellular fusion." [GOC:dph, GOC:tb]
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0031137 ! regulation of conjugation with cellular fusion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032005 ! signal transduction involved in conjugation with cellular fusion
relationship: regulates GO:0032005 ! signal transduction involved in conjugation with cellular fusion

[Term]
id: GO:0060239
name: positive regulation of signal transduction involved in conjugation with cellular fusion
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the series of molecular signals that bring about the relay, amplification or dampening of a signal generated in response to a cue, such as starvation or pheromone exposure, in organisms that undergo conjugation with cellular fusion." [GOC:dph, GOC:tb]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0031139 ! positive regulation of conjugation with cellular fusion
is_a: GO:0060238 ! regulation of signal transduction involved in conjugation with cellular fusion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032005 ! signal transduction involved in conjugation with cellular fusion
relationship: positively_regulates GO:0032005 ! signal transduction involved in conjugation with cellular fusion

[Term]
id: GO:0060240
name: negative regulation of signal transduction involved in conjugation with cellular fusion
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the series of molecular signals that bring about the relay, amplification or dampening of a signal generated in response to a cue, such as starvation or pheromone exposure, in organisms that undergo conjugation with cellular fusion." [GOC:dph, GOC:tb]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0031138 ! negative regulation of conjugation with cellular fusion
is_a: GO:0060238 ! regulation of signal transduction involved in conjugation with cellular fusion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032005 ! signal transduction involved in conjugation with cellular fusion
relationship: negatively_regulates GO:0032005 ! signal transduction involved in conjugation with cellular fusion

[Term]
id: GO:0060241
name: lysozyme inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a lysozyme, an enzyme that hydrolyses the beta- (1,4) glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine in peptidoglycan." [GOC:dph]
is_a: GO:0004857 ! enzyme inhibitor activity
relationship: negatively_regulates GO:0003796 ! lysozyme activity

[Term]
id: GO:0060242
name: contact inhibition
namespace: biological_process
def: "The cellular process in which cells stop growing or dividing in response to increased cell density." [GOC:dph, PMID:17376520]
xref: Wikipedia:Contact_inhibition
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0060243
name: negative regulation of cell growth involved in contact inhibition
namespace: biological_process
def: "The negative regulation of cell growth in response to increased cell density." [GOC:dph]
is_a: GO:0030308 ! negative regulation of cell growth
intersection_of: GO:0030308 ! negative regulation of cell growth
intersection_of: part_of GO:0060242 ! contact inhibition
relationship: part_of GO:0060242 ! contact inhibition

[Term]
id: GO:0060244
name: negative regulation of cell proliferation involved in contact inhibition
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of cell proliferation in response to cell density." [GOC:dph]
is_a: GO:0008285 ! negative regulation of cell proliferation
intersection_of: GO:0008285 ! negative regulation of cell proliferation
intersection_of: part_of GO:0060242 ! contact inhibition
relationship: part_of GO:0060242 ! contact inhibition

[Term]
id: GO:0060245
name: detection of cell density
namespace: biological_process
def: "The series of events in which information about the density of cells in a population is received and converted into a molecular signal." [GOC:dph]
is_a: GO:0009595 ! detection of biotic stimulus

[Term]
id: GO:0060246
name: detection of cell density by contact stimulus
namespace: biological_process
def: "The series of events in which information about the density of cells in a population is received by direct cell-cell contact and is converted into a molecular signal." [GOC:dph]
is_a: GO:0060245 ! detection of cell density

[Term]
id: GO:0060247
name: detection of cell density by secreted molecule
namespace: biological_process
def: "The series of events in which information about the density of cells in a population is received by the detection of a secreted molecule and is converted into a molecular signal." [GOC:dph]
is_a: GO:0060245 ! detection of cell density

[Term]
id: GO:0060248
name: detection of cell density by contact stimulus involved in contact inhibition
namespace: biological_process
def: "The series of events in which information about the density of cells in a population is received by direct cell-cell contact and is converted into a molecular signal, resulting in the cessation of cell growth or proliferation." [GOC:dph]
is_a: GO:0060246 ! detection of cell density by contact stimulus
intersection_of: GO:0060246 ! detection of cell density by contact stimulus
intersection_of: part_of GO:0060242 ! contact inhibition
relationship: part_of GO:0060242 ! contact inhibition

[Term]
id: GO:0060249
name: anatomical structure homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of an internal steady state within a defined anatomical structure of an organism, including control of cellular proliferation and death and control of metabolic function. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph]
synonym: "anatomical structure maintenance" EXACT [GOC:dph]
is_a: GO:0042592 ! homeostatic process

[Term]
id: GO:0060250
name: germ-line stem-cell niche homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of an internal steady state within the germ-line stem-cell niche. This includes control of cellular proliferation and death and control of metabolic function that allows the niche to continue to function. A gem-line stem-cell niche is an anatomical structure that regulates how germ-line stem-cells are used and saves them from depletion." [GOC:dph]
synonym: "germ-line stem-cell niche maintenance" EXACT [GOC:dph, GOC:tb]
synonym: "maintenance of germ line stem cell niche" EXACT [GOC:dph]
synonym: "maintenance of germ line stem-cell niche" EXACT [GOC:dph]
synonym: "maintenance of germ-line stem cell niche" EXACT [GOC:dph]
synonym: "maintenance of germ-line stem-cell niche" EXACT [GOC:dph]
is_a: GO:0060249 ! anatomical structure homeostasis

[Term]
id: GO:0060251
name: regulation of glial cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glial cell proliferation." [GOC:dph, GOC:tb]
is_a: GO:0014013 ! regulation of gliogenesis
is_a: GO:0042127 ! regulation of cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0014009 ! glial cell proliferation
relationship: regulates GO:0014009 ! glial cell proliferation

[Term]
id: GO:0060252
name: positive regulation of glial cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of glial cell proliferation." [GOC:dph, GOC:sl, GOC:tb]
is_a: GO:0008284 ! positive regulation of cell proliferation
is_a: GO:0014015 ! positive regulation of gliogenesis
is_a: GO:0060251 ! regulation of glial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0014009 ! glial cell proliferation
relationship: positively_regulates GO:0014009 ! glial cell proliferation

[Term]
id: GO:0060253
name: negative regulation of glial cell proliferation
namespace: biological_process
def: "Any process that stops or decreases the rate or extent of glial cell proliferation." [GOC:dph, GOC:sl, GOC:tb]
is_a: GO:0008285 ! negative regulation of cell proliferation
is_a: GO:0014014 ! negative regulation of gliogenesis
is_a: GO:0060251 ! regulation of glial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0014009 ! glial cell proliferation
relationship: negatively_regulates GO:0014009 ! glial cell proliferation

[Term]
id: GO:0060254
name: regulation of N-terminal protein palmitoylation
namespace: biological_process
def: "Any process that modulates the rate frequency or extent of the covalent attachment of a palmitoyl group to the N-terminal amino acid residue of a protein." [GOC:dph, GOC:tb]
is_a: GO:1903059 ! regulation of protein lipidation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006500 ! N-terminal protein palmitoylation
relationship: regulates GO:0006500 ! N-terminal protein palmitoylation

[Term]
id: GO:0060255
name: regulation of macromolecule metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]
subset: gosubset_prok
is_a: GO:0019222 ! regulation of metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043170 ! macromolecule metabolic process
relationship: regulates GO:0043170 ! macromolecule metabolic process

[Term]
id: GO:0060256
name: regulation of flocculation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the non-sexual aggregation of single-celled organisms." [GOC:dph, GOC:tb]
is_a: GO:0043900 ! regulation of multi-organism process
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000128 ! flocculation
relationship: regulates GO:0000128 ! flocculation

[Term]
id: GO:0060257
name: negative regulation of flocculation
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the non-sexual aggregation of single-celled organisms." [GOC:dph, GOC:tb]
is_a: GO:0043901 ! negative regulation of multi-organism process
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0060256 ! regulation of flocculation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000128 ! flocculation
relationship: negatively_regulates GO:0000128 ! flocculation

[Term]
id: GO:0060258
name: negative regulation of filamentous growth
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the process in which a multicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape." [GOC:dph, GOC:tb]
is_a: GO:0010570 ! regulation of filamentous growth
is_a: GO:0045926 ! negative regulation of growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030447 ! filamentous growth
relationship: negatively_regulates GO:0030447 ! filamentous growth

[Term]
id: GO:0060259
name: regulation of feeding behavior
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the behavior associated with the intake of food." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "regulation of feeding behaviour" EXACT [GOC:dph, GOC:tb]
is_a: GO:0050795 ! regulation of behavior
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007631 ! feeding behavior
relationship: regulates GO:0007631 ! feeding behavior

[Term]
id: GO:0060260
name: regulation of transcription initiation from RNA polymerase II promoter
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter." [GOC:dph, GOC:tb, GOC:txnOH]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:2000142 ! regulation of DNA-templated transcription, initiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006367 ! transcription initiation from RNA polymerase II promoter
relationship: regulates GO:0006367 ! transcription initiation from RNA polymerase II promoter

[Term]
id: GO:0060261
name: positive regulation of transcription initiation from RNA polymerase II promoter
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter." [GOC:dph, GOC:tb, GOC:txnOH]
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
is_a: GO:0060260 ! regulation of transcription initiation from RNA polymerase II promoter
is_a: GO:2000144 ! positive regulation of DNA-templated transcription, initiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006367 ! transcription initiation from RNA polymerase II promoter
relationship: positively_regulates GO:0006367 ! transcription initiation from RNA polymerase II promoter

[Term]
id: GO:0060262
name: negative regulation of N-terminal protein palmitoylation
namespace: biological_process
def: "Any process that decreases the rate frequency or extent of the covalent attachment of a palmitoyl group to the N-terminal amino acid residue of a protein." [GOC:dph, GOC:tb]
is_a: GO:0060254 ! regulation of N-terminal protein palmitoylation
is_a: GO:1903060 ! negative regulation of protein lipidation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006500 ! N-terminal protein palmitoylation
relationship: negatively_regulates GO:0006500 ! N-terminal protein palmitoylation

[Term]
id: GO:0060263
name: regulation of respiratory burst
namespace: biological_process
def: "Any process that modulates the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:dph, GOC:tb]
is_a: GO:0019222 ! regulation of metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045730 ! respiratory burst
relationship: regulates GO:0045730 ! respiratory burst

[Term]
id: GO:0060264
name: regulation of respiratory burst involved in inflammatory response
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]
synonym: "regulation of respiratory burst involved in acute inflammatory response" BROAD []
is_a: GO:0002697 ! regulation of immune effector process
is_a: GO:0045088 ! regulation of innate immune response
is_a: GO:0050727 ! regulation of inflammatory response
is_a: GO:0051239 ! regulation of multicellular organismal process
is_a: GO:0060263 ! regulation of respiratory burst
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002536 ! respiratory burst involved in inflammatory response
relationship: regulates GO:0002536 ! respiratory burst involved in inflammatory response

[Term]
id: GO:0060265
name: positive regulation of respiratory burst involved in inflammatory response
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "positive regulation of respiratory burst involved in acute inflammatory response" BROAD []
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0045089 ! positive regulation of innate immune response
is_a: GO:0050729 ! positive regulation of inflammatory response
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0060264 ! regulation of respiratory burst involved in inflammatory response
is_a: GO:0060267 ! positive regulation of respiratory burst
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002536 ! respiratory burst involved in inflammatory response
relationship: positively_regulates GO:0002536 ! respiratory burst involved in inflammatory response

[Term]
id: GO:0060266
name: negative regulation of respiratory burst involved in inflammatory response
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "negative regulation of respiratory burst involved in acute inflammatory response" BROAD []
is_a: GO:0002698 ! negative regulation of immune effector process
is_a: GO:0045824 ! negative regulation of innate immune response
is_a: GO:0050728 ! negative regulation of inflammatory response
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0060264 ! regulation of respiratory burst involved in inflammatory response
is_a: GO:0060268 ! negative regulation of respiratory burst
is_a: GO:0060284 ! regulation of cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002536 ! respiratory burst involved in inflammatory response
relationship: negatively_regulates GO:0002536 ! respiratory burst involved in inflammatory response

[Term]
id: GO:0060267
name: positive regulation of respiratory burst
namespace: biological_process
def: "Any process that increases the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:dph, GOC:tb]
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0060263 ! regulation of respiratory burst
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045730 ! respiratory burst
relationship: positively_regulates GO:0045730 ! respiratory burst

[Term]
id: GO:0060268
name: negative regulation of respiratory burst
namespace: biological_process
def: "Any process that decreases the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:dph, GOC:tb]
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0060263 ! regulation of respiratory burst
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045730 ! respiratory burst
relationship: negatively_regulates GO:0045730 ! respiratory burst

[Term]
id: GO:0060269
name: centripetally migrating follicle cell migration
namespace: biological_process
def: "The cell migration process in which a follicle cell migrates as part of an epithelial sheet between the nurse cells and the oocyte. At the end of migration, they cover the anterior of the oocyte." [GOC:dph]
is_a: GO:0007297 ! ovarian follicle cell migration

[Term]
id: GO:0060270
name: main body follicle cell migration
namespace: biological_process
def: "The ovarian follicle cell migration process in which follicle cells migrate posteriorly to form a columnar epithelium over the oocyte." [GOC:dph]
is_a: GO:0007297 ! ovarian follicle cell migration

[Term]
id: GO:0060271
name: cilium morphogenesis
namespace: biological_process
def: "A process that is carried out at the cellular level and in which the structure of a cilium is organized." [GOC:BHF, GOC:dph]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.
synonym: "cilium organization" RELATED [GOC:dph]
is_a: GO:0048858 ! cell projection morphogenesis

[Term]
id: GO:0060272
name: embryonic skeletal joint morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of skeletal joints are generated and organized during the embryonic phase. A skeletal joint is the connecting structure between the bones of the skeleton." [GOC:bf, GOC:BHF, GOC:dph, UBERON:0000982]
is_a: GO:0048704 ! embryonic skeletal system morphogenesis
relationship: part_of GO:0072498 ! embryonic skeletal joint development

[Term]
id: GO:0060273
name: crying behavior
namespace: biological_process
def: "The behavior in which an organism sheds tears, often accompanied by non-verbal vocalizations and in response to external or internal stimuli." [GOC:dph]
is_a: GO:0044708 ! single-organism behavior

[Term]
id: GO:0060274
name: maintenance of stationary phase
namespace: biological_process
def: "The homeostatic process in which a population of cells changes its metabolic activity resulting in the rate of death in the population equaling the rate of reproduction. Stationary phase can be in response to limited nutrients or a build-up of toxic substances in the environment." [GOC:dph]
is_a: GO:0048874 ! homeostasis of number of cells in a free-living population

[Term]
id: GO:0060275
name: maintenance of stationary phase in response to starvation
namespace: biological_process
def: "The homeostatic process in which a population of cells changes its metabolic activity resulting in the rate of death in the population equaling the rate of reproduction in response to limited nutrients in the environment." [GOC:dph]
is_a: GO:0042594 ! response to starvation
is_a: GO:0060274 ! maintenance of stationary phase

[Term]
id: GO:0060276
name: maintenance of stationary phase in response to toxin
namespace: biological_process
def: "The homeostatic process in which a population of cells changes its metabolic activity resulting in the rate of death in the population equaling the rate of reproduction in response to a build-up of toxins in the environment." [GOC:dph]
is_a: GO:0060274 ! maintenance of stationary phase
relationship: part_of GO:0009636 ! response to toxic substance

[Term]
id: GO:0060277
name: obsolete negative regulation of transcription involved in G1 phase of mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that stop, prevents or decreases transcription as part of the G1 phase of the mitotic cell cycle." [GOC:dph, GOC:tb]
comment: This term was made obsolete because it is unclear exactly what it means. It could mean either 'regulation of transcription during phase X' or 'regulation of transition between phase X and phase Y'.
synonym: "negative regulation of transcription from RNA polymerase II promoter during G1 phase of mitotic cell cycle" RELATED [GOC:dph, GOC:tb]
synonym: "negative regulation of transcription involved in G1 phase of mitotic cell cycle" EXACT []
is_obsolete: true
consider: GO:0071930

[Term]
id: GO:0060278
name: regulation of ovulation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary." [GOC:dph, GOC:kmv, GOC:tb]
is_a: GO:0043900 ! regulation of multi-organism process
is_a: GO:0051239 ! regulation of multicellular organismal process
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030728 ! ovulation
relationship: regulates GO:0030728 ! ovulation

[Term]
id: GO:0060279
name: positive regulation of ovulation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary." [GOC:dph, GOC:kmv, GOC:tb]
is_a: GO:0043902 ! positive regulation of multi-organism process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0060278 ! regulation of ovulation
is_a: GO:2000243 ! positive regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030728 ! ovulation
relationship: positively_regulates GO:0030728 ! ovulation

[Term]
id: GO:0060280
name: negative regulation of ovulation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary." [GOC:dph, GOC:kmv, GOC:tb]
is_a: GO:0043901 ! negative regulation of multi-organism process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0060278 ! regulation of ovulation
is_a: GO:2000242 ! negative regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030728 ! ovulation
relationship: negatively_regulates GO:0030728 ! ovulation

[Term]
id: GO:0060281
name: regulation of oocyte development
namespace: biological_process
def: "Any process that modulates the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:tb, PMID:2394318]
is_a: GO:0043900 ! regulation of multi-organism process
is_a: GO:0051239 ! regulation of multicellular organismal process
is_a: GO:0060284 ! regulation of cell development
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048599 ! oocyte development
relationship: regulates GO:0048599 ! oocyte development

[Term]
id: GO:0060282
name: positive regulation of oocyte development
namespace: biological_process
def: "Any process that increases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:tb]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0043902 ! positive regulation of multi-organism process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0060281 ! regulation of oocyte development
is_a: GO:2000243 ! positive regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048599 ! oocyte development
relationship: positively_regulates GO:0048599 ! oocyte development

[Term]
id: GO:0060283
name: negative regulation of oocyte development
namespace: biological_process
def: "Any process that decreases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:tb]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0043901 ! negative regulation of multi-organism process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0060281 ! regulation of oocyte development
is_a: GO:2000242 ! negative regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048599 ! oocyte development
relationship: negatively_regulates GO:0048599 ! oocyte development

[Term]
id: GO:0060284
name: regulation of cell development
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph, GOC:tb]
is_a: GO:0045595 ! regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048468 ! cell development
relationship: regulates GO:0048468 ! cell development

[Term]
id: GO:0060285
name: cilium-dependent cell motility
namespace: biological_process
alt_id: GO:0071974
def: "Cell motility due to the motion of one or more eukaryotic cilia. A eukaryotic cilium is a specialized organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:dgh, GOC:dph, GOC:krc, GOC:mlg, GOC:mtg_cambridge_2013]
comment: Note that we deem eukaryotic cilia and microtubule-based flagella to be equivalent.
synonym: "ciliary cell motility" RELATED []
synonym: "cilium cell motility" EXACT []
synonym: "microtubule-based flagellar cell motility" EXACT []
is_a: GO:0001539 ! cilium or flagellum-dependent cell motility
relationship: has_part GO:0003341 ! cilium movement

[Term]
id: GO:0060286
name: obsolete flagellar cell motility
namespace: biological_process
def: "OBSOLETE. Cell motility due to the motion of one or more flagella." [GOC:dgh, GOC:dph, GOC:mlg]
comment: This term was made obsolete because microtubule-based flagellum (GO:0009434) and motile cilium (GO:0031514), as referenced by this term, were determined to be equivalent and merged. When a merge for this term was considered, it was noticed that both eukaryotic and prokaryotic proteins are annotated to it because its meaning had been ambiguous so obsoletion was considered safest.
synonym: "flagellar cell motility" EXACT []
is_obsolete: true
consider: GO:0060285
consider: GO:0071973

[Term]
id: GO:0060287
name: epithelial cilium movement involved in determination of left/right asymmetry
namespace: biological_process
def: "The movement of cilia of epithelial cells resulting in the transport of signals which determine asymmetry in an organism's body plan with respect to the left and right halves." [GOC:dgh, GOC:dph, GOC:mlg]
synonym: "cilium movement involved in determinationof L/R asymmetry" EXACT []
is_a: GO:0003351 ! epithelial cilium movement
intersection_of: GO:0003351 ! epithelial cilium movement
intersection_of: part_of GO:0007368 ! determination of left/right symmetry
relationship: part_of GO:0007368 ! determination of left/right symmetry

[Term]
id: GO:0060288
name: formation of a compartment boundary
namespace: biological_process
def: "Formation of a lineage restriction boundary within a developing tissue which does not correspond to some morphological barrier." [GOC:dph]
synonym: "compartment boundary formation" EXACT []
is_a: GO:0048859 ! formation of anatomical boundary
relationship: part_of GO:0007386 ! compartment pattern specification

[Term]
id: GO:0060289
name: compartment boundary maintenance
namespace: biological_process
def: "A homeostatic process involved in the maintenance of a compartment boundary. A compartment boundary is a lineage restriction boundary within a developing tissue which does not correspond to some morphological barrier." [GOC:dph]
is_a: GO:0001894 ! tissue homeostasis
relationship: part_of GO:0007386 ! compartment pattern specification

[Term]
id: GO:0060290
name: transdifferentiation
namespace: biological_process
def: "The conversion of a differentiated cell of one fate into a differentiated cell of another fate without first undergoing cell division or reversion to a more primitive or stem cell-like fate." [GOC:dph, GOC:kmv]
xref: Wikipedia:Transdifferentiation
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0060291
name: long-term synaptic potentiation
namespace: biological_process
def: "A process that modulates synaptic plasticity such that synapses are changed resulting in the increase in the rate, or frequency of synaptic transmission at the synapse." [GOC:dgh, GOC:dph]
synonym: "long-term potentiation" BROAD [GOC:dph]
synonym: "LTP" RELATED [GOC:dph]
is_a: GO:0048167 ! regulation of synaptic plasticity
is_a: GO:0050806 ! positive regulation of synaptic transmission

[Term]
id: GO:0060292
name: long term synaptic depression
namespace: biological_process
def: "A process that modulates synaptic plasticity such that synapses are changed resulting in the decrease in the rate, or frequency of synaptic transmission at the synapse." [GOC:dgh, GOC:dph]
synonym: "long term depression" BROAD [GOC:dph]
synonym: "LTD" RELATED [GOC:dph]
is_a: GO:0048167 ! regulation of synaptic plasticity
is_a: GO:0050805 ! negative regulation of synaptic transmission

[Term]
id: GO:0060293
name: germ plasm
namespace: cellular_component
def: "Differentiated cytoplasm associated with a pole of an oocyte, egg or early embryo that will be inherited by the cells that will give rise to the germ line." [GOC:dph]
xref: Wikipedia:Germ_plasm
is_a: GO:0045495 ! pole plasm

[Term]
id: GO:0060294
name: cilium movement involved in cell motility
namespace: biological_process
def: "Movement of cilia mediated by motor proteins that contributes to the movement of a cell." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0003341 ! cilium movement
intersection_of: GO:0003341 ! cilium movement
intersection_of: part_of GO:0048870 ! cell motility
relationship: part_of GO:0048870 ! cell motility
relationship: part_of GO:0060285 ! cilium-dependent cell motility

[Term]
id: GO:0060295
name: regulation of cilium movement involved in cell motility
namespace: biological_process
def: "Any process that modulates the rate frequency or extent of cilium movement involved in ciliary motility." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:1902019 ! regulation of cilium-dependent cell motility
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060294 ! cilium movement involved in cell motility
relationship: regulates GO:0060294 ! cilium movement involved in cell motility

[Term]
id: GO:0060296
name: regulation of cilium beat frequency involved in ciliary motility
namespace: biological_process
def: "Any process that modulates the frequency of cilium beating involved in ciliary motility." [GOC:BHF, GOC:cilia, GOC:dph, GOC:krc, GOC:tb]
is_a: GO:0003356 ! regulation of cilium beat frequency
is_a: GO:0060295 ! regulation of cilium movement involved in cell motility
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0060297
name: regulation of sarcomere organization
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "regulation of sarcomere organisation" EXACT [GOC:mah]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0032956 ! regulation of actin cytoskeleton organization
is_a: GO:0051153 ! regulation of striated muscle cell differentiation
is_a: GO:0060284 ! regulation of cell development
is_a: GO:1902115 ! regulation of organelle assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045214 ! sarcomere organization
relationship: regulates GO:0045214 ! sarcomere organization

[Term]
id: GO:0060298
name: positive regulation of sarcomere organization
namespace: biological_process
def: "Any process that increases the rate, frequency or extent myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "positive regulation of sarcomere organisation" EXACT [GOC:mah]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0051155 ! positive regulation of striated muscle cell differentiation
is_a: GO:0051495 ! positive regulation of cytoskeleton organization
is_a: GO:0060297 ! regulation of sarcomere organization
is_a: GO:1902117 ! positive regulation of organelle assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045214 ! sarcomere organization
relationship: positively_regulates GO:0045214 ! sarcomere organization

[Term]
id: GO:0060299
name: negative regulation of sarcomere organization
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "negative regulation of sarcomere organisation" EXACT [GOC:mah]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0051154 ! negative regulation of striated muscle cell differentiation
is_a: GO:0051494 ! negative regulation of cytoskeleton organization
is_a: GO:0060297 ! regulation of sarcomere organization
is_a: GO:1902116 ! negative regulation of organelle assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045214 ! sarcomere organization
relationship: negatively_regulates GO:0045214 ! sarcomere organization

[Term]
id: GO:0060300
name: regulation of cytokine activity
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the activity of a molecule that controls the survival, growth, differentiation and effector function of tissues and cells." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:1900120 ! regulation of receptor binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0005125 ! cytokine activity
relationship: regulates GO:0005125 ! cytokine activity

[Term]
id: GO:0060301
name: positive regulation of cytokine activity
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the activity of a molecule that controls the survival, growth, differentiation and effector function of tissues and cells." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0060300 ! regulation of cytokine activity
is_a: GO:1900122 ! positive regulation of receptor binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0005125 ! cytokine activity
relationship: positively_regulates GO:0005125 ! cytokine activity

[Term]
id: GO:0060302
name: negative regulation of cytokine activity
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the activity of a molecule that controls the survival, growth, differentiation and effector function of tissues and cells." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0060300 ! regulation of cytokine activity
is_a: GO:1900121 ! negative regulation of receptor binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0005125 ! cytokine activity
relationship: negatively_regulates GO:0005125 ! cytokine activity

[Term]
id: GO:0060303
name: regulation of nucleosome density
namespace: biological_process
def: "Any process that modulates the number of nucleosomes in a given region of a chromosome." [GOC:dph, GOC:tb]
is_a: GO:0034728 ! nucleosome organization
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0060304
name: regulation of phosphatidylinositol dephosphorylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reaction involving the removal of one or more phosphate groups from a phosphatidylinositol." [GOC:dph, GOC:tb]
synonym: "regulation of phosphoinositide dephosphorylation" EXACT [GOC:curators]
is_a: GO:0035303 ! regulation of dephosphorylation
is_a: GO:0060255 ! regulation of macromolecule metabolic process
is_a: GO:1903725 ! regulation of phospholipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0046856 ! phosphatidylinositol dephosphorylation
relationship: regulates GO:0046856 ! phosphatidylinositol dephosphorylation

[Term]
id: GO:0060305
name: regulation of cell diameter
namespace: biological_process
def: "Any process that modulates the diameter of a cell, the length of a line segment that crosses through the center of a circular section through a cell." [GOC:dph, GOC:tb]
synonym: "regulation of cell width" BROAD [GOC:dph, GOC:tb]
is_a: GO:0008361 ! regulation of cell size

[Term]
id: GO:0060306
name: regulation of membrane repolarization
namespace: biological_process
def: "Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential, usually from positive to negative." [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11, GOC:tb]
is_a: GO:0034765 ! regulation of ion transmembrane transport
is_a: GO:0042391 ! regulation of membrane potential
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0086009 ! membrane repolarization
relationship: regulates GO:0086009 ! membrane repolarization

[Term]
id: GO:0060307
name: regulation of ventricular cardiac muscle cell membrane repolarization
namespace: biological_process
def: "Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential in a ventricular cardiomyocyte." [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11, GOC:tb]
synonym: "electrocardiogram T wave" RELATED [GOC:dph, GOC:tb]
synonym: "regulation of ventricular cardiac muscle cell repolarization" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of ventricular cardiac muscle repolarization" RELATED [GOC:dph, GOC:tb]
synonym: "regulation of ventricular cardiomyocyte membrane repolarization" EXACT []
synonym: "ventricular repolarization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0099623 ! regulation of cardiac muscle cell membrane repolarization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0099625 ! ventricular cardiac muscle cell membrane repolarization
relationship: regulates GO:0099625 ! ventricular cardiac muscle cell membrane repolarization

[Term]
id: GO:0060308
name: GTP cyclohydrolase I regulator activity
namespace: molecular_function
def: "Modulates the activity of GTP cyclohydrolase I. GTP cyclohydrolase I activity catalyzes the reaction: GTP + 2 H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate." [GOC:dph, GOC:tb]
is_a: GO:0030234 ! enzyme regulator activity
relationship: has_part GO:0044549 ! GTP cyclohydrolase binding
relationship: regulates GO:0003934 ! GTP cyclohydrolase I activity

[Term]
id: GO:0060309
name: elastin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of elastin. Elastin is a glycoprotein which is randomly coiled and crosslinked to form elastic fibers that are found in connective tissue." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "elastin breakdown" EXACT []
synonym: "elastin catabolism" EXACT []
synonym: "elastin degradation" EXACT []
is_a: GO:0006516 ! glycoprotein catabolic process
is_a: GO:0051541 ! elastin metabolic process

[Term]
id: GO:0060310
name: regulation of elastin catabolic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of elastin catabolism, the chemical reactions and pathways resulting in the breakdown of elastin." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "regulation of elastin breakdown" RELATED [GOC:dph, GOC:tb]
synonym: "regulation of elastin catabolism" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of elastin degradation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:0042176 ! regulation of protein catabolic process
is_a: GO:1903018 ! regulation of glycoprotein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060309 ! elastin catabolic process
relationship: regulates GO:0060309 ! elastin catabolic process

[Term]
id: GO:0060311
name: negative regulation of elastin catabolic process
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of elastin catabolism, the chemical reactions and pathways resulting in the breakdown of elastin." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "down-regulation of elastin catabolic process" EXACT []
synonym: "negative regulation of elastin breakdown" EXACT []
synonym: "negative regulation of elastin catabolism" EXACT []
synonym: "negative regulation of elastin degradation" EXACT []
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:0042177 ! negative regulation of protein catabolic process
is_a: GO:0060310 ! regulation of elastin catabolic process
is_a: GO:1903019 ! negative regulation of glycoprotein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060309 ! elastin catabolic process
relationship: negatively_regulates GO:0060309 ! elastin catabolic process

[Term]
id: GO:0060312
name: regulation of blood vessel remodeling
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of blood vessel remodeling, the reorganization or renovation of existing blood vessels." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0034103 ! regulation of tissue remodeling
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001974 ! blood vessel remodeling
relationship: regulates GO:0001974 ! blood vessel remodeling

[Term]
id: GO:0060313
name: negative regulation of blood vessel remodeling
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of blood vessel remodeling, the reorganization or renovation of existing blood vessels." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "down-regulation of blood vessel remodeling" EXACT [GOC:dph, GOC:tb]
synonym: "inhibition of blood vessel remodeling" NARROW [GOC:dph, GOC:tb]
is_a: GO:0034104 ! negative regulation of tissue remodeling
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0060312 ! regulation of blood vessel remodeling
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001974 ! blood vessel remodeling
relationship: negatively_regulates GO:0001974 ! blood vessel remodeling

[Term]
id: GO:0060314
name: regulation of ryanodine-sensitive calcium-release channel activity
namespace: biological_process
def: "Any process that modulates the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010469 ! regulation of receptor activity
is_a: GO:0050848 ! regulation of calcium-mediated signaling
is_a: GO:0051279 ! regulation of release of sequestered calcium ion into cytosol
is_a: GO:1901019 ! regulation of calcium ion transmembrane transporter activity
is_a: GO:2001257 ! regulation of cation channel activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0005219 ! ryanodine-sensitive calcium-release channel activity
relationship: regulates GO:0005219 ! ryanodine-sensitive calcium-release channel activity

[Term]
id: GO:0060315
name: negative regulation of ryanodine-sensitive calcium-release channel activity
namespace: biological_process
def: "Any process that decreases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0050849 ! negative regulation of calcium-mediated signaling
is_a: GO:0051280 ! negative regulation of release of sequestered calcium ion into cytosol
is_a: GO:0060314 ! regulation of ryanodine-sensitive calcium-release channel activity
is_a: GO:1901020 ! negative regulation of calcium ion transmembrane transporter activity
is_a: GO:2000272 ! negative regulation of receptor activity
is_a: GO:2001258 ! negative regulation of cation channel activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0005219 ! ryanodine-sensitive calcium-release channel activity
relationship: negatively_regulates GO:0005219 ! ryanodine-sensitive calcium-release channel activity

[Term]
id: GO:0060316
name: positive regulation of ryanodine-sensitive calcium-release channel activity
namespace: biological_process
def: "Any process that increases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0050850 ! positive regulation of calcium-mediated signaling
is_a: GO:0051281 ! positive regulation of release of sequestered calcium ion into cytosol
is_a: GO:0060314 ! regulation of ryanodine-sensitive calcium-release channel activity
is_a: GO:1901021 ! positive regulation of calcium ion transmembrane transporter activity
is_a: GO:2000273 ! positive regulation of receptor activity
is_a: GO:2001259 ! positive regulation of cation channel activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0005219 ! ryanodine-sensitive calcium-release channel activity
relationship: positively_regulates GO:0005219 ! ryanodine-sensitive calcium-release channel activity

[Term]
id: GO:0060317
name: cardiac epithelial to mesenchymal transition
namespace: biological_process
def: "A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BHF, GOC:dph, PMID:16314491, PMID:1996351]
synonym: "heart epithelial to mesenchymal transition" EXACT []
is_a: GO:0001837 ! epithelial to mesenchymal transition
relationship: part_of GO:0003007 ! heart morphogenesis

[Term]
id: GO:0060318
name: definitive erythrocyte differentiation
namespace: biological_process
def: "Erythrocyte differentiation which occurs as part of the process of definitive hemopoiesis." [GOC:add, GOC:BHF, GOC:dph]
synonym: "definitive erythropoiesis" EXACT []
synonym: "definitive RBC differentiation" EXACT [CL:0000232]
synonym: "definitive red blood cell differentiation" EXACT [CL:0000232]
is_a: GO:0030218 ! erythrocyte differentiation
relationship: part_of GO:0060216 ! definitive hemopoiesis

[Term]
id: GO:0060319
name: primitive erythrocyte differentiation
namespace: biological_process
def: "Erythrocyte differentiation which occurs as part of the process of primitive hemopoiesis." [GOC:add, GOC:BHF, GOC:dph]
synonym: "primitive erythropoiesis" EXACT [GOC:add, GOC:dph]
synonym: "primitive RBC differentiation" EXACT [CL:0000232]
synonym: "primitive red blood cell differentiation" EXACT [CL:0000232]
is_a: GO:0030218 ! erythrocyte differentiation
relationship: part_of GO:0060215 ! primitive hemopoiesis

[Term]
id: GO:0060320
name: rejection of self pollen
namespace: biological_process
def: "The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the rejection of the self pollen by cells in the stigma." [GOC:dph, GOC:tb]
is_a: GO:0048544 ! recognition of pollen

[Term]
id: GO:0060321
name: acceptance of pollen
namespace: biological_process
def: "The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the acceptance of pollen by cells in the stigma." [GOC:dph, GOC:tb]
synonym: "acceptance of non-self pollen" RELATED [GOC:dph, GOC:tb]
synonym: "acceptance of self pollen" NARROW [GOC:dph, GOC:tb]
is_a: GO:0048544 ! recognition of pollen

[Term]
id: GO:0060322
name: head development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a head from an initial condition to its mature state. The head is the anterior-most division of the body." [GOC:dph]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development

[Term]
id: GO:0060323
name: head morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the head are generated and organized. The head is the anterior-most division of the body." [GOC:dph]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0010171 ! body morphogenesis
relationship: part_of GO:0060322 ! head development

[Term]
id: GO:0060324
name: face development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a face from an initial condition to its mature state. The face is the ventral division of the head." [GOC:dph]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0060322 ! head development

[Term]
id: GO:0060325
name: face morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the face are generated and organized. The face is the ventral division of the head." [GOC:dph]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0060323 ! head morphogenesis
relationship: part_of GO:0060324 ! face development

[Term]
id: GO:0060326
name: cell chemotaxis
namespace: biological_process
def: "The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [GOC:dph]
is_a: GO:0006935 ! chemotaxis
is_a: GO:0016477 ! cell migration
relationship: part_of GO:0070887 ! cellular response to chemical stimulus

[Term]
id: GO:0060327
name: cytoplasmic actin-based contraction involved in cell motility
namespace: biological_process
def: "The actin filament-based movement by which cytoplasmic actin filaments slide past one another resulting in a contraction that propels the cell from one place to another." [GOC:dph]
is_a: GO:0070252 ! actin-mediated cell contraction
intersection_of: GO:0070252 ! actin-mediated cell contraction
intersection_of: part_of GO:0048870 ! cell motility
relationship: part_of GO:0048870 ! cell motility

[Term]
id: GO:0060328
name: cytoplasmic actin-based contraction involved in forward cell motility
namespace: biological_process
def: "The actin filament-based movement by which cytoplasmic actin filaments slide past one another resulting in a contraction that propels the cell in the direction that has been defined as the front of the cell." [GOC:dph]
synonym: "cytoplasmic actin-based contraction involved in forward cell locomotion" RELATED []
is_a: GO:0060327 ! cytoplasmic actin-based contraction involved in cell motility

[Term]
id: GO:0060329
name: cytoplasmic actin-based contraction involved in rearward cell motility
namespace: biological_process
def: "The actin filament-based movement by which cytoplasmic actin filaments slide past one another resulting in a contraction that propels the cell in the direction that has been defined as the rear of the cell." [GOC:dph]
synonym: "cytoplasmic actin-based contraction involved in rearward cell locomotion" RELATED []
is_a: GO:0060327 ! cytoplasmic actin-based contraction involved in cell motility

[Term]
id: GO:0060330
name: regulation of response to interferon-gamma
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of a response to interferon-gamma. Response to interferon gamma is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus." [GOC:dph]
synonym: "regulation of response to gamma-interferon" RELATED []
synonym: "regulation of response to immune interferon" EXACT []
synonym: "regulation of response to type II IFN" BROAD []
synonym: "regulation of response to type II interferon" BROAD []
is_a: GO:0045088 ! regulation of innate immune response
is_a: GO:0060759 ! regulation of response to cytokine stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034341 ! response to interferon-gamma
relationship: regulates GO:0034341 ! response to interferon-gamma

[Term]
id: GO:0060331
name: negative regulation of response to interferon-gamma
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of a response to interferon-gamma. Response to interferon gamma is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus." [GOC:dph]
synonym: "negative regulation of response to gamma-interferon" RELATED []
synonym: "negative regulation of response to immune interferon" EXACT []
synonym: "negative regulation of response to type II IFN" BROAD []
synonym: "negative regulation of response to type II interferon" BROAD []
is_a: GO:0045824 ! negative regulation of innate immune response
is_a: GO:0060330 ! regulation of response to interferon-gamma
is_a: GO:0060761 ! negative regulation of response to cytokine stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034341 ! response to interferon-gamma
relationship: negatively_regulates GO:0034341 ! response to interferon-gamma

[Term]
id: GO:0060332
name: positive regulation of response to interferon-gamma
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of a response to interferon-gamma. Response to interferon gamma is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus." [GOC:dph]
synonym: "positive regulation of response to gamma-interferon" RELATED []
synonym: "positive regulation of response to immune interferon" EXACT []
synonym: "positive regulation of response to type II IFN" BROAD []
synonym: "positive regulation of response to type II interferon" BROAD []
is_a: GO:0045089 ! positive regulation of innate immune response
is_a: GO:0060330 ! regulation of response to interferon-gamma
is_a: GO:0060760 ! positive regulation of response to cytokine stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034341 ! response to interferon-gamma
relationship: positively_regulates GO:0034341 ! response to interferon-gamma

[Term]
id: GO:0060333
name: interferon-gamma-mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of interferon-gamma to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far." [GOC:add, GOC:dph, GOC:signaling, PR:000000017]
synonym: "gamma-interferon-mediated signaling pathway" EXACT [GOC:dph]
synonym: "immune interferon signaling pathway" EXACT [GOC:dph]
synonym: "interferon-gamma-mediated signalling pathway" EXACT [GOC:mah]
synonym: "type II IFN-mediated signaling pathway" BROAD []
synonym: "type II interferon-mediated signaling pathway" BROAD [GOC:dph]
xref: Reactome:REACT_25078 "Interferon gamma signaling, Homo sapiens"
is_a: GO:0019221 ! cytokine-mediated signaling pathway
relationship: part_of GO:0071346 ! cellular response to interferon-gamma

[Term]
id: GO:0060334
name: regulation of interferon-gamma-mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the series of molecular events generated as a consequence of interferon-gamma binding to a cell surface receptor." [GOC:dph]
synonym: "regulation of gamma-interferon-mediated signaling pathway" RELATED [GOC:dph]
synonym: "regulation of immune interferon signaling pathway" EXACT [GOC:dph]
synonym: "regulation of interferon-gamma-mediated signalling pathway" EXACT [GOC:mah]
synonym: "regulation of type II IFN-mediated signaling pathway" BROAD [GOC:dph]
synonym: "regulation of type II interferon-mediated signaling pathway" BROAD [GOC:dph]
xref: Reactome:REACT_24980 "Regulation of IFNG signaling, Homo sapiens"
is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway
is_a: GO:0060330 ! regulation of response to interferon-gamma
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060333 ! interferon-gamma-mediated signaling pathway
relationship: regulates GO:0060333 ! interferon-gamma-mediated signaling pathway

[Term]
id: GO:0060335
name: positive regulation of interferon-gamma-mediated signaling pathway
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the series of molecular events generated as a consequence of interferon-gamma binding to a cell surface receptor." [GOC:dph]
synonym: "positive regulation of gamma-interferon-mediated signaling pathway" RELATED [GOC:dph]
synonym: "positive regulation of immune interferon-mediated signaling pathway" EXACT [GOC:dph]
synonym: "positive regulation of interferon-gamma-mediated signalling pathway" EXACT [GOC:mah]
synonym: "positive regulation of type II IFN-mediated pathway" BROAD [GOC:dph]
synonym: "positive regulation of type II interferon-mediated signaling pathway" BROAD [GOC:dph]
is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway
is_a: GO:0060332 ! positive regulation of response to interferon-gamma
is_a: GO:0060334 ! regulation of interferon-gamma-mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060333 ! interferon-gamma-mediated signaling pathway
relationship: positively_regulates GO:0060333 ! interferon-gamma-mediated signaling pathway

[Term]
id: GO:0060336
name: negative regulation of interferon-gamma-mediated signaling pathway
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of interferon-gamma binding to a cell surface receptor." [GOC:dph]
synonym: "negative regulation of gamma-interferon-mediated signaling pathway" RELATED [GOC:dph]
synonym: "negative regulation of immune interferon-mediated signaling pathway" EXACT [GOC:dph]
synonym: "negative regulation of interferon-gamma-mediated signalling pathway" EXACT [GOC:mah]
synonym: "negative regulation of type II IFN-mediated signaling pathway" BROAD [GOC:dph]
synonym: "negative regulation of type II interferon-mediated signaling pathway" BROAD [GOC:dph]
is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway
is_a: GO:0060331 ! negative regulation of response to interferon-gamma
is_a: GO:0060334 ! regulation of interferon-gamma-mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060333 ! interferon-gamma-mediated signaling pathway
relationship: negatively_regulates GO:0060333 ! interferon-gamma-mediated signaling pathway

[Term]
id: GO:0060337
name: type I interferon signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of a type I interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:dph, GOC:signaling, PR:000025848]
synonym: "type I interferon-activated signaling pathway" EXACT [GOC:signaling]
synonym: "type I interferon-mediated signaling pathway" RELATED [GOC:signaling]
synonym: "type I interferon-mediated signalling pathway" EXACT [GOC:mah]
xref: Reactome:REACT_25162 "Interferon alpha/beta signaling, Homo sapiens"
is_a: GO:0019221 ! cytokine-mediated signaling pathway
relationship: part_of GO:0071357 ! cellular response to type I interferon

[Term]
id: GO:0060338
name: regulation of type I interferon-mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of a type I interferon-mediated signaling pathway. A type I interferon-mediated signaling pathway is the series of molecular events generated as a consequence of a type I interferon binding to a cell surface receptor." [GOC:dph]
synonym: "regulation of type I interferon-mediated signalling pathway" EXACT [GOC:mah]
xref: Reactome:REACT_25216 "Regulation of IFNA signaling, Homo sapiens"
is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway
is_a: GO:0045088 ! regulation of innate immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060337 ! type I interferon signaling pathway
relationship: regulates GO:0060337 ! type I interferon signaling pathway

[Term]
id: GO:0060339
name: negative regulation of type I interferon-mediated signaling pathway
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of a type I interferon-mediated signaling pathway. A type I interferon-mediated signaling pathway is the series of molecular events generated as a consequence of a type I interferon binding to a cell surface receptor." [GOC:dph]
synonym: "negative regulation of type I interferon-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway
is_a: GO:0045824 ! negative regulation of innate immune response
is_a: GO:0060338 ! regulation of type I interferon-mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060337 ! type I interferon signaling pathway
relationship: negatively_regulates GO:0060337 ! type I interferon signaling pathway

[Term]
id: GO:0060340
name: positive regulation of type I interferon-mediated signaling pathway
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of a type I interferon-mediated signaling pathway. A type I interferon-mediated signaling pathway is the series of molecular events generated as a consequence of a type I interferon binding to a cell surface receptor." [GOC:dph]
synonym: "positive regulation of type I interferon-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway
is_a: GO:0045089 ! positive regulation of innate immune response
is_a: GO:0060338 ! regulation of type I interferon-mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060337 ! type I interferon signaling pathway
relationship: positively_regulates GO:0060337 ! type I interferon signaling pathway

[Term]
id: GO:0060341
name: regulation of cellular localization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell." [GOC:dph, GOC:tb]
synonym: "regulation of cellular localisation" EXACT [GOC:mah]
is_a: GO:0032879 ! regulation of localization
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051641 ! cellular localization
relationship: regulates GO:0051641 ! cellular localization

[Term]
id: GO:0060342
name: photoreceptor inner segment membrane
namespace: cellular_component
def: "The membrane surrounding the inner segment of a vertebrate photoreceptor. The photoreceptor inner segment contains mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs." [GOC:dph]
is_a: GO:0097458 ! neuron part
is_a: GO:0098590 ! plasma membrane region
relationship: part_of GO:0001917 ! photoreceptor inner segment
relationship: part_of GO:0005886 ! plasma membrane

[Term]
id: GO:0060343
name: trabecula formation
namespace: biological_process
def: "The process of creating a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue." [GOC:dph]
synonym: "trabecula biogenesis" RELATED [GOC:dph]
synonym: "trabeculation" EXACT [GOC:dph]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0009887 ! organ morphogenesis
relationship: part_of GO:0061383 ! trabecula morphogenesis

[Term]
id: GO:0060344
name: liver trabecula formation
namespace: biological_process
def: "The process of creating a trabecula in the liver. A trabecula is a tissue element in the form of a small beam, strut or rod." [GOC:dph]
synonym: "liver trabecula biogenesis" RELATED []
synonym: "liver trabeculation" EXACT [GOC:dph]
is_a: GO:0060343 ! trabecula formation
relationship: part_of GO:0001889 ! liver development

[Term]
id: GO:0060345
name: spleen trabecula formation
namespace: biological_process
def: "The process of creating a trabecula in the spleen. A trabecula is a tissue element in the form of a small beam, strut or rod." [GOC:dph]
synonym: "spleen trabecula biogenesis" RELATED [GOC:dph]
synonym: "spleen trabeculation" EXACT [GOC:dph]
is_a: GO:0060343 ! trabecula formation
relationship: part_of GO:0048536 ! spleen development

[Term]
id: GO:0060346
name: bone trabecula formation
namespace: biological_process
def: "The process of creating a trabecula in the bone. A trabecula is a tissue element in the form of a small beam, strut or rod." [GOC:dph]
synonym: "bone trabecula biogenesis" RELATED [GOC:dph]
synonym: "bone trabeculation" EXACT [GOC:dph]
synonym: "skeletal trabecula biogenesis" RELATED [GOC:dph]
synonym: "skeletal trabecula formation" EXACT [GOC:dph]
synonym: "skeletal trabeculation" EXACT [GOC:dph]
is_a: GO:0060343 ! trabecula formation
relationship: part_of GO:0048705 ! skeletal system morphogenesis
relationship: part_of GO:0061430 ! bone trabecula morphogenesis

[Term]
id: GO:0060347
name: heart trabecula formation
namespace: biological_process
def: "The process of creating a trabecula in the heart. A trabecula is a tissue element in the form of a small beam, strut or rod." [GOC:dph]
synonym: "cardiac trabecula formation" EXACT [GOC:dph]
synonym: "cardiac trabeculation" EXACT [GOC:dph]
synonym: "heart trabecula biogenesis" RELATED [GOC:dph]
synonym: "heart trabeculation" EXACT [GOC:dph]
is_a: GO:0060343 ! trabecula formation
relationship: part_of GO:0003206 ! cardiac chamber morphogenesis
relationship: part_of GO:0061384 ! heart trabecula morphogenesis

[Term]
id: GO:0060348
name: bone development
namespace: biological_process
def: "The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components." [GOC:dph]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048513 ! animal organ development
relationship: part_of GO:0001501 ! skeletal system development

[Term]
id: GO:0060349
name: bone morphogenesis
namespace: biological_process
def: "The process in which bones are generated and organized." [GOC:dph]
is_a: GO:0009887 ! organ morphogenesis
relationship: part_of GO:0048705 ! skeletal system morphogenesis
relationship: part_of GO:0060348 ! bone development

[Term]
id: GO:0060350
name: endochondral bone morphogenesis
namespace: biological_process
def: "The process in which bones are generated and organized as a result of the conversion of initial cartilaginous anlage into bone." [GOC:dph, PMID:11680679]
is_a: GO:0060349 ! bone morphogenesis

[Term]
id: GO:0060351
name: cartilage development involved in endochondral bone morphogenesis
namespace: biological_process
def: "The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones." [GOC:dph]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0051216 ! cartilage development
intersection_of: GO:0051216 ! cartilage development
intersection_of: part_of GO:0060350 ! endochondral bone morphogenesis
relationship: part_of GO:0060350 ! endochondral bone morphogenesis

[Term]
id: GO:0060352
name: cell adhesion molecule production
namespace: biological_process
def: "The appearance of a cell adhesion molecule due to biosynthesis or secretion." [GOC:BHF, GOC:rl]
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0060353
name: regulation of cell adhesion molecule production
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of cell adhesion molecule production. Cell adhesion molecule production is the appearance of a cell adhesion molecule as a result of its biosynthesis or a decrease in its catabolism." [GOC:BHF, GOC:rl]
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060352 ! cell adhesion molecule production
relationship: regulates GO:0060352 ! cell adhesion molecule production

[Term]
id: GO:0060354
name: negative regulation of cell adhesion molecule production
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of cell adhesion molecule production. Cell adhesion molecule production is the appearance of a cell adhesion molecule as a result of its biosynthesis or a decrease in its catabolism." [GOC:BHF, GOC:rl]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0060353 ! regulation of cell adhesion molecule production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060352 ! cell adhesion molecule production
relationship: negatively_regulates GO:0060352 ! cell adhesion molecule production

[Term]
id: GO:0060355
name: positive regulation of cell adhesion molecule production
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of cell adhesion molecule production. Cell adhesion molecule production is the appearance of a cell adhesion molecule as a result of its biosynthesis or a decrease in its catabolism." [GOC:BHF, GOC:rl]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0060353 ! regulation of cell adhesion molecule production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060352 ! cell adhesion molecule production
relationship: positively_regulates GO:0060352 ! cell adhesion molecule production

[Term]
id: GO:0060356
name: leucine import
namespace: biological_process
def: "The directed movement of leucine into a cell or organelle." [GOC:dph, GOC:tb]
synonym: "L-leucine import" NARROW []
synonym: "L-leucine uptake" NARROW []
synonym: "leucine uptake" EXACT []
is_a: GO:0015820 ! leucine transport
is_a: GO:0043090 ! amino acid import

[Term]
id: GO:0060357
name: regulation of leucine import
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of leucine import. Leucine import is the directed movement of leucine into a cell or organelle." [GOC:dph, GOC:tb]
synonym: "regulation of L-leucine import" NARROW [GOC:dph, GOC:tb]
synonym: "regulation of L-leucine uptake" NARROW [GOC:dph, GOC:tb]
synonym: "regulation of leucine uptake" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010958 ! regulation of amino acid import
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060356 ! leucine import
relationship: regulates GO:0060356 ! leucine import

[Term]
id: GO:0060358
name: negative regulation of leucine import
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of leucine import. Leucine import is the directed movement of leucine into a cell or organelle." [GOC:dph, GOC:tb]
is_a: GO:0051956 ! negative regulation of amino acid transport
is_a: GO:0060357 ! regulation of leucine import
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060356 ! leucine import
relationship: negatively_regulates GO:0060356 ! leucine import

[Term]
id: GO:0060359
name: response to ammonium ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium ion stimulus." [GOC:dph, GOC:tb]
is_a: GO:1901698 ! response to nitrogen compound

[Term]
id: GO:0060360
name: negative regulation of leucine import in response to ammonium ion
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of leucine import as a result of an ammonium ion stimulus. Leucine import is the directed movement of leucine into a cell or organelle." [GOC:dph, GOC:tb]
synonym: "negative regulation of leucine uptake in response to ammonium ion" EXACT []
is_a: GO:0060358 ! negative regulation of leucine import
relationship: part_of GO:0071242 ! cellular response to ammonium ion

[Term]
id: GO:0060361
name: flight
namespace: biological_process
def: "Self-propelled movement of an organism from one location to another through the air, usually by means of active wing movement." [GOC:dph]
is_a: GO:0040011 ! locomotion

[Term]
id: GO:0060362
name: flight involved in flight behavior
namespace: biological_process
def: "Self-propelled movement of an organism from one location to another through the air that is part of the organism's response to external or internal stimuli resulting in flight." [GOC:dph]
is_a: GO:0031987 ! locomotion involved in locomotory behavior
is_a: GO:0060361 ! flight
intersection_of: GO:0060361 ! flight
intersection_of: part_of GO:0007629 ! flight behavior
relationship: part_of GO:0007629 ! flight behavior

[Term]
id: GO:0060363
name: cranial suture morphogenesis
namespace: biological_process
def: "The process in which any suture between cranial bones is generated and organized." [GOC:dph, GOC:pr, GOC:sl]
is_a: GO:0097094 ! craniofacial suture morphogenesis

[Term]
id: GO:0060364
name: frontal suture morphogenesis
namespace: biological_process
def: "The process in which the frontal suture is generated and organized." [GOC:dph, GOC:sl]
synonym: "interfrontal suture morphogenesis" EXACT []
is_a: GO:0060363 ! cranial suture morphogenesis

[Term]
id: GO:0060365
name: coronal suture morphogenesis
namespace: biological_process
def: "The process in which the coronal suture is generated and organized." [GOC:dph, GOC:sl]
is_a: GO:0060363 ! cranial suture morphogenesis

[Term]
id: GO:0060366
name: lambdoid suture morphogenesis
namespace: biological_process
def: "The process in which the lambdoid suture is generated and organized." [GOC:dph, GOC:sl]
is_a: GO:0060363 ! cranial suture morphogenesis

[Term]
id: GO:0060367
name: sagittal suture morphogenesis
namespace: biological_process
def: "The process in which the sagittal suture is generated and organized." [GOC:dph, GOC:sl]
is_a: GO:0060363 ! cranial suture morphogenesis

[Term]
id: GO:0060368
name: regulation of Fc receptor mediated stimulatory signaling pathway
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the Fc receptor mediated stimulatory signaling pathway. The Fc receptor mediated stimulatory signaling pathway is a series of molecular signals generated as a consequence of a the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of activating or perpetuating an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region." [GOC:dph, GOC:tb]
synonym: "regulation of Fc receptor mediated stimulatory signalling pathway" EXACT [GOC:mah]
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0050776 ! regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002431 ! Fc receptor mediated stimulatory signaling pathway
relationship: regulates GO:0002431 ! Fc receptor mediated stimulatory signaling pathway

[Term]
id: GO:0060369
name: positive regulation of Fc receptor mediated stimulatory signaling pathway
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the Fc receptor mediated stimulatory signaling pathway. The Fc receptor mediated stimulatory signaling pathway is a series of molecular signals generated as a consequence of a the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of activating or perpetuating an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "positive regulation of Fc receptor mediated stimulatory signalling pathway" EXACT [GOC:mah]
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0060368 ! regulation of Fc receptor mediated stimulatory signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002431 ! Fc receptor mediated stimulatory signaling pathway
relationship: positively_regulates GO:0002431 ! Fc receptor mediated stimulatory signaling pathway

[Term]
id: GO:0060370
name: susceptibility to T cell mediated cytotoxicity
namespace: biological_process
def: "The process of causing a cell to become susceptible to T cell mediated cytotoxicity." [GOC:dph, GOC:tb]
is_a: GO:0001916 ! positive regulation of T cell mediated cytotoxicity

[Term]
id: GO:0060371
name: regulation of atrial cardiac muscle cell membrane depolarization
namespace: biological_process
def: "Any process that modulates the establishment or extent of a membrane potential in the depolarizing direction away from the resting potential in an atrial cardiomyocyte." [GOC:dph, GOC:tb]
synonym: "atrial depolarization" RELATED [GOC:dph, GOC:tb]
synonym: "electrocardiogram PR interval" RELATED [GOC:dph, GOC:tb]
synonym: "regulation of atrial cardiac muscle cell depolarization" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of atrial cardiomyocyte membrane depolarization" EXACT []
is_a: GO:0003254 ! regulation of membrane depolarization

[Term]
id: GO:0060372
name: regulation of atrial cardiac muscle cell membrane repolarization
namespace: biological_process
def: "Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential in an atrial cardiomyocyte." [GOC:dph, GOC:tb]
synonym: "atrial repolarization" RELATED [GOC:dph, GOC:tb]
synonym: "electrocardiogram QRS complex" RELATED [GOC:dph, GOC:tb]
synonym: "regulation of atrial cardiac muscle cell repolarization" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of atrial cardiomyocyte membrane repolarization" EXACT []
is_a: GO:0099623 ! regulation of cardiac muscle cell membrane repolarization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0099624 ! atrial cardiac muscle cell membrane repolarization
relationship: regulates GO:0099624 ! atrial cardiac muscle cell membrane repolarization

[Term]
id: GO:0060373
name: regulation of ventricular cardiac muscle cell membrane depolarization
namespace: biological_process
def: "Any process that modulates the establishment or extent of a membrane potential in the depolarizing direction away from the resting potential in a ventricular cardiomyocyte." [GOC:dph, GOC:tb]
synonym: "electrocardiogram QRS complex" RELATED [GOC:dph, GOC:tb]
synonym: "regulation of ventricular cardiomyocyte membrane depolarization" EXACT []
synonym: "ventricular depolarization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0003254 ! regulation of membrane depolarization

[Term]
id: GO:0060374
name: mast cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation." [GOC:dph, GOC:tb]
is_a: GO:0002573 ! myeloid leukocyte differentiation

[Term]
id: GO:0060375
name: regulation of mast cell differentiation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of mast cell differentiation, the process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation." [GOC:dph, GOC:tb]
is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060374 ! mast cell differentiation
relationship: regulates GO:0060374 ! mast cell differentiation

[Term]
id: GO:0060376
name: positive regulation of mast cell differentiation
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of mast cell differentiation, the process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation." [GOC:dph, GOC:tb]
is_a: GO:0002763 ! positive regulation of myeloid leukocyte differentiation
is_a: GO:0060375 ! regulation of mast cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060374 ! mast cell differentiation
relationship: positively_regulates GO:0060374 ! mast cell differentiation

[Term]
id: GO:0060377
name: negative regulation of mast cell differentiation
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of mast cell differentiation, the process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation." [GOC:dph, GOC:tb]
is_a: GO:0002762 ! negative regulation of myeloid leukocyte differentiation
is_a: GO:0060375 ! regulation of mast cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060374 ! mast cell differentiation
relationship: negatively_regulates GO:0060374 ! mast cell differentiation

[Term]
id: GO:0060378
name: regulation of brood size
namespace: biological_process
def: "Any process that modulates the extent of brood size. Brood size is the number of progeny that survive embryogenesis and are cared for at one time." [GOC:dph, GOC:tb]
is_a: GO:0044703 ! multi-organism reproductive process
is_a: GO:0044706 ! multi-multicellular organism process
is_a: GO:0048609 ! multicellular organismal reproductive process
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0060379
name: cardiac muscle cell myoblast differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a cardiac myoblast. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life." [GOC:dph, GOC:tb]
synonym: "cardiac myoblast differentiation" RELATED [GOC:dph, GOC:tb]
synonym: "myocardial precursor cell differentiation" EXACT [GOC:mtg_heart]
is_a: GO:0010002 ! cardioblast differentiation
is_a: GO:0045445 ! myoblast differentiation

[Term]
id: GO:0060380
name: regulation of single-stranded telomeric DNA binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of binding to single-stranded telomeric DNA." [GOC:dph, GOC:tb]
synonym: "regulation of telomeric ssDNA binding" EXACT [GOC:mah]
is_a: GO:1904742 ! regulation of telomeric DNA binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043047 ! single-stranded telomeric DNA binding
relationship: regulates GO:0043047 ! single-stranded telomeric DNA binding

[Term]
id: GO:0060381
name: positive regulation of single-stranded telomeric DNA binding
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of single-stranded telomeric DNA binding." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "positive regulation of telomeric ssDNA binding" EXACT [GOC:mah]
is_a: GO:0060380 ! regulation of single-stranded telomeric DNA binding
is_a: GO:1904744 ! positive regulation of telomeric DNA binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043047 ! single-stranded telomeric DNA binding
relationship: positively_regulates GO:0043047 ! single-stranded telomeric DNA binding

[Term]
id: GO:0060382
name: regulation of DNA strand elongation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of DNA strand elongation. DNA strand elongation is the DNA metabolic process in which a DNA strand is synthesized by adding nucleotides to the 3' end of an existing DNA stand." [GOC:dph, GOC:tb]
is_a: GO:0051052 ! regulation of DNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0022616 ! DNA strand elongation
relationship: regulates GO:0022616 ! DNA strand elongation

[Term]
id: GO:0060383
name: positive regulation of DNA strand elongation
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of DNA strand elongation. DNA strand elongation is the DNA metabolic process in which a DNA strand is synthesized by adding nucleotides to the 3' end of an existing DNA stand." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0051054 ! positive regulation of DNA metabolic process
is_a: GO:0060382 ! regulation of DNA strand elongation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0022616 ! DNA strand elongation
relationship: positively_regulates GO:0022616 ! DNA strand elongation

[Term]
id: GO:0060384
name: innervation
namespace: biological_process
def: "The process in which a nerve invades a tissue and makes functional synaptic connection within the tissue." [GOC:dph, GOC:sart]
is_a: GO:0044707 ! single-multicellular organism process
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0021675 ! nerve development

[Term]
id: GO:0060385
name: axonogenesis involved in innervation
namespace: biological_process
def: "The neurite development process that generates a long process of a neuron, as it invades a target tissue." [GOC:dph, GOC:sart]
is_a: GO:0007409 ! axonogenesis
intersection_of: GO:0007409 ! axonogenesis
intersection_of: part_of GO:0060384 ! innervation
relationship: part_of GO:0060384 ! innervation

[Term]
id: GO:0060386
name: synapse assembly involved in innervation
namespace: biological_process
def: "The assembly of a synapse within a target tissue in which a nerve is invading." [GOC:dph, GOC:pr, GOC:sart]
synonym: "synapse biogenesis involved in innervation" EXACT []
synonym: "synaptogenesis involved in innervation" EXACT []
is_a: GO:0007416 ! synapse assembly
intersection_of: GO:0007416 ! synapse assembly
intersection_of: part_of GO:0060384 ! innervation
relationship: part_of GO:0060384 ! innervation

[Term]
id: GO:0060387
name: fertilization envelope
namespace: cellular_component
def: "A structure that lies outside the plasma membrane and surrounds the egg. The fertilization envelope forms from the vitelline membrane after fertilization as a result of cortical granule release." [GOC:dph, ISBN:0878932437]
synonym: "fertilization membrane" RELATED []
is_a: GO:0035805 ! egg coat

[Term]
id: GO:0060388
name: vitelline envelope
namespace: cellular_component
def: "A glycoprotein-based structure that lies outside the plasma membrane and surrounds the egg before fertilization." [GOC:dph, ISBN:0878932437]
synonym: "fertilization membrane" RELATED []
is_a: GO:0035805 ! egg coat

[Term]
id: GO:0060389
name: pathway-restricted SMAD protein phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group on to a pathway restricted SMAD protein. A pathway restricted SMAD protein is an effector protein that acts directly downstream of the transforming growth factor family receptor." [GOC:dph, ISBN:3527303782]
is_a: GO:0006468 ! protein phosphorylation
relationship: part_of GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway

[Term]
id: GO:0060390
name: regulation of SMAD protein import into nucleus
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of SMAD protein import into the nucleus, i.e. the directed movement of a SMAD proteins from the cytoplasm into the nucleus. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "regulation of SMAD protein nuclear translocation" NARROW [GOC:mah]
is_a: GO:0042306 ! regulation of protein import into nucleus
is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007184 ! SMAD protein import into nucleus
relationship: regulates GO:0007184 ! SMAD protein import into nucleus

[Term]
id: GO:0060391
name: positive regulation of SMAD protein import into nucleus
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of SMAD protein import into the nucleus, i.e. the directed movement of a SMAD proteins from the cytoplasm into the nucleus. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "positive regulation of SMAD protein nuclear translocation" NARROW [GOC:mah]
is_a: GO:0042307 ! positive regulation of protein import into nucleus
is_a: GO:0060390 ! regulation of SMAD protein import into nucleus
is_a: GO:0090100 ! positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007184 ! SMAD protein import into nucleus
relationship: positively_regulates GO:0007184 ! SMAD protein import into nucleus

[Term]
id: GO:0060392
name: negative regulation of SMAD protein import into nucleus
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of SMAD protein import into the nucleus, i.e. the directed movement of a SMAD proteins from the cytoplasm into the nucleus. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "negative regulation of SMAD protein nuclear translocation" NARROW [GOC:mah]
is_a: GO:0042308 ! negative regulation of protein import into nucleus
is_a: GO:0060390 ! regulation of SMAD protein import into nucleus
is_a: GO:0090101 ! negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007184 ! SMAD protein import into nucleus
relationship: negatively_regulates GO:0007184 ! SMAD protein import into nucleus

[Term]
id: GO:0060393
name: regulation of pathway-restricted SMAD protein phosphorylation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0001932 ! regulation of protein phosphorylation
is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060389 ! pathway-restricted SMAD protein phosphorylation
relationship: regulates GO:0060389 ! pathway-restricted SMAD protein phosphorylation

[Term]
id: GO:0060394
name: negative regulation of pathway-restricted SMAD protein phosphorylation
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0001933 ! negative regulation of protein phosphorylation
is_a: GO:0060393 ! regulation of pathway-restricted SMAD protein phosphorylation
is_a: GO:0090101 ! negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060389 ! pathway-restricted SMAD protein phosphorylation
relationship: negatively_regulates GO:0060389 ! pathway-restricted SMAD protein phosphorylation

[Term]
id: GO:0060395
name: SMAD protein signal transduction
namespace: biological_process
def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the activity of a SMAD protein, and ultimately effecting a change in the functioning of the cell." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0007165 ! signal transduction
relationship: part_of GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway

[Term]
id: GO:0060396
name: growth hormone receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand." [GOC:BHF, GOC:dph, PMID:11445442]
synonym: "cellular response to growth hormone" RELATED [GOC:dph]
synonym: "GH receptor signaling pathway" RELATED [GOC:dph]
synonym: "growth hormone receptor signalling pathway" EXACT [GOC:dph]
is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway
relationship: part_of GO:0071378 ! cellular response to growth hormone stimulus

[Term]
id: GO:0060397
name: JAK-STAT cascade involved in growth hormone signaling pathway
namespace: biological_process
def: "The process in which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of physiological ligands to the growth hormone receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes." [GOC:BHF, GOC:dph, PMID:11445442]
synonym: "JAK-STAT cascade involved in growth hormone signalling pathway" EXACT [GOC:dph]
xref: Reactome:REACT_111133 "Growth hormone receptor signaling, Homo sapiens"
is_a: GO:0007259 ! JAK-STAT cascade
intersection_of: GO:0007259 ! JAK-STAT cascade
intersection_of: part_of GO:0060396 ! growth hormone receptor signaling pathway
relationship: part_of GO:0060396 ! growth hormone receptor signaling pathway

[Term]
id: GO:0060398
name: regulation of growth hormone receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the growth hormone receptor signaling pathway. The growth hormone receptor signaling pathway is the series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand." [GOC:BHF, GOC:dph]
synonym: "regulation of growth hormone receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0009966 ! regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060396 ! growth hormone receptor signaling pathway
relationship: regulates GO:0060396 ! growth hormone receptor signaling pathway

[Term]
id: GO:0060399
name: positive regulation of growth hormone receptor signaling pathway
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the growth hormone receptor signaling pathway. The growth hormone receptor signaling pathway is the series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand." [GOC:BHF, GOC:dph]
synonym: "positive regulation of growth hormone receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0060398 ! regulation of growth hormone receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060396 ! growth hormone receptor signaling pathway
relationship: positively_regulates GO:0060396 ! growth hormone receptor signaling pathway

[Term]
id: GO:0060400
name: negative regulation of growth hormone receptor signaling pathway
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the growth hormone receptor signaling pathway. The growth hormone receptor signaling pathway is the series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand." [GOC:dph]
synonym: "negative regulation of growth hormone receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0060398 ! regulation of growth hormone receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060396 ! growth hormone receptor signaling pathway
relationship: negatively_regulates GO:0060396 ! growth hormone receptor signaling pathway

[Term]
id: GO:0060401
name: cytosolic calcium ion transport
namespace: biological_process
def: "The directed movement of calcium ions (Ca2+) into, out of or within the cytosol." [GOC:dph, GOC:tb]
is_a: GO:0006816 ! calcium ion transport

[Term]
id: GO:0060402
name: calcium ion transport into cytosol
namespace: biological_process
def: "The directed movement of calcium ions (Ca2+) into the cytosol." [GOC:dph, GOC:tb]
is_a: GO:0007204 ! positive regulation of cytosolic calcium ion concentration
is_a: GO:0060401 ! cytosolic calcium ion transport
is_a: GO:1902582 ! single-organism intracellular transport

[Term]
id: GO:0060403
name: post-mating oviposition
namespace: biological_process
def: "The deposition of eggs, either fertilized or not, upon a surface or into a medium, following mating." [GOC:dph, GOC:tb]
is_a: GO:0018991 ! oviposition
is_a: GO:0045297 ! post-mating behavior

[Term]
id: GO:0060404
name: axonemal microtubule depolymerization
namespace: biological_process
def: "The removal of tubulin heterodimers from one or both ends of an axonemal microtubule. An axonemal microtubule is a microtubule in the axoneme of a cilium or flagellum; an axoneme contains nine modified doublet microtubules surrounding a pair of single microtubules." [GOC:dph, GOC:tb]
is_a: GO:0007019 ! microtubule depolymerization
intersection_of: GO:0007019 ! microtubule depolymerization
intersection_of: occurs_in GO:0005930 ! axoneme
relationship: occurs_in GO:0005930 ! axoneme

[Term]
id: GO:0060405
name: regulation of penile erection
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of penile erection. Penile erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow." [GOC:add, GOC:dph, GOC:tb]
is_a: GO:0043900 ! regulation of multi-organism process
is_a: GO:0051239 ! regulation of multicellular organismal process
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043084 ! penile erection
relationship: regulates GO:0043084 ! penile erection

[Term]
id: GO:0060406
name: positive regulation of penile erection
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of penile erection. Penile erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow." [GOC:dph, GOC:tb]
is_a: GO:0043902 ! positive regulation of multi-organism process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0060405 ! regulation of penile erection
is_a: GO:2000243 ! positive regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043084 ! penile erection
relationship: positively_regulates GO:0043084 ! penile erection

[Term]
id: GO:0060407
name: negative regulation of penile erection
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of penile erection. Penile erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow." [GOC:dph, GOC:tb]
is_a: GO:0043901 ! negative regulation of multi-organism process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0060405 ! regulation of penile erection
is_a: GO:2000242 ! negative regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043084 ! penile erection
relationship: negatively_regulates GO:0043084 ! penile erection

[Term]
id: GO:0060408
name: regulation of acetylcholine metabolic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:dph, GOC:tb]
is_a: GO:0001505 ! regulation of neurotransmitter levels
is_a: GO:0033238 ! regulation of cellular amine metabolic process
is_a: GO:0080090 ! regulation of primary metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008291 ! acetylcholine metabolic process
relationship: regulates GO:0008291 ! acetylcholine metabolic process

[Term]
id: GO:0060409
name: positive regulation of acetylcholine metabolic process
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:dph, GOC:tb]
is_a: GO:0033240 ! positive regulation of cellular amine metabolic process
is_a: GO:0050806 ! positive regulation of synaptic transmission
is_a: GO:0060408 ! regulation of acetylcholine metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008291 ! acetylcholine metabolic process
relationship: positively_regulates GO:0008291 ! acetylcholine metabolic process

[Term]
id: GO:0060410
name: negative regulation of acetylcholine metabolic process
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:dph, GOC:tb]
is_a: GO:0033239 ! negative regulation of cellular amine metabolic process
is_a: GO:0050805 ! negative regulation of synaptic transmission
is_a: GO:0060408 ! regulation of acetylcholine metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008291 ! acetylcholine metabolic process
relationship: negatively_regulates GO:0008291 ! acetylcholine metabolic process

[Term]
id: GO:0060411
name: cardiac septum morphogenesis
namespace: biological_process
alt_id: GO:0003280
def: "The process in which the anatomical structure of a cardiac septum is generated and organized. A cardiac septum is a partition that separates parts of the heart." [GOC:dph, GOC:mtg_heart]
synonym: "heart septum morphogenesis" EXACT []
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0003206 ! cardiac chamber morphogenesis
relationship: part_of GO:0003279 ! cardiac septum development

[Term]
id: GO:0060412
name: ventricular septum morphogenesis
namespace: biological_process
def: "The developmental process in which a ventricular septum is generated and organized. A ventricular septum is an anatomical structure that separates the lower chambers (ventricles) of the heart from one another." [GOC:dph]
synonym: "interventricular septum morphogenesis" EXACT [GOC:dph]
is_a: GO:0060411 ! cardiac septum morphogenesis
relationship: part_of GO:0003281 ! ventricular septum development

[Term]
id: GO:0060413
name: atrial septum morphogenesis
namespace: biological_process
alt_id: GO:0003287
def: "The developmental process in which atrial septum is generated and organized. The atrial septum separates the upper chambers (the atria) of the heart from one another." [GOC:dph, GOC:mtg_heart]
synonym: "interatrial septum morphogenesis" EXACT [GOC:dph]
is_a: GO:0060411 ! cardiac septum morphogenesis
relationship: part_of GO:0003209 ! cardiac atrium morphogenesis
relationship: part_of GO:0003283 ! atrial septum development

[Term]
id: GO:0060414
name: aorta smooth muscle tissue morphogenesis
namespace: biological_process
def: "The process in which the structure of the smooth muscle tissue surrounding the aorta is generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body." [GOC:bf, GOC:dgh, GOC:dph, Wikipedia:Aorta]
is_a: GO:0060415 ! muscle tissue morphogenesis
relationship: part_of GO:0035909 ! aorta morphogenesis
relationship: part_of GO:0048745 ! smooth muscle tissue development

[Term]
id: GO:0060415
name: muscle tissue morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of muscle tissue are generated and organized. Muscle tissue consists of a set of cells that are part of an organ and carry out a contractive function." [GOC:dph]
is_a: GO:0048729 ! tissue morphogenesis
relationship: part_of GO:0048644 ! muscle organ morphogenesis

[Term]
id: GO:0060416
name: response to growth hormone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone stimulus. Growth hormone is a peptide hormone that binds to the growth hormone receptor and stimulates growth." [GOC:BHF, GOC:dph]
synonym: "response to growth hormone stimulus" EXACT [GOC:dos]
is_a: GO:0043434 ! response to peptide hormone

[Term]
id: GO:0060417
name: yolk
namespace: cellular_component
def: "The cytoplasmic part that serves as a nutrient reserve or energy source for the developing embryo." [GOC:dph, GOC:tb, PMID:18046696]
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0060418
name: yolk plasma
namespace: cellular_component
def: "Discrete structures that partition the water-soluble portion of the yolk of oocytes and ova, which may or may not be membrane enclosed." [GOC:dph, GOC:tb, PMID:18046696]
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0060417 ! yolk

[Term]
id: GO:0060419
name: heart growth
namespace: biological_process
def: "The increase in size or mass of the heart." [GOC:dph, GOC:tb]
is_a: GO:0035265 ! organ growth
relationship: part_of GO:0007507 ! heart development

[Term]
id: GO:0060420
name: regulation of heart growth
namespace: biological_process
def: "Any process that modulates the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart." [GOC:dph, GOC:tb]
is_a: GO:0046620 ! regulation of organ growth
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060419 ! heart growth
relationship: regulates GO:0060419 ! heart growth

[Term]
id: GO:0060421
name: positive regulation of heart growth
namespace: biological_process
def: "Any process that increases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0046622 ! positive regulation of organ growth
is_a: GO:0060420 ! regulation of heart growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060419 ! heart growth
relationship: positively_regulates GO:0060419 ! heart growth

[Term]
id: GO:0060422
name: peptidyl-dipeptidase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a peptidyl-dipeptidase. Peptidyl-dipeptidase activity catalyzes the release of C-terminal dipeptides from a polypeptide chain." [GOC:dph, GOC:tb]
is_a: GO:0030414 ! peptidase inhibitor activity

[Term]
id: GO:0060423
name: foregut regionalization
namespace: biological_process
def: "The pattern specification process that results in the spatial subdivision of an axis or axes along the foregut to define an area or volume in which specific patterns of cell differentiation will take place." [GOC:dph, GOC:mtg_lung]
is_a: GO:0009952 ! anterior/posterior pattern specification

[Term]
id: GO:0060424
name: lung field specification
namespace: biological_process
def: "The process that results in the delineation of a specific region of the foregut into the area in which the lung will develop." [GOC:dph, GOC:mtg_lung]
synonym: "lung specification" EXACT [GOC:dph, GOC:mtg_lung]
is_a: GO:0010092 ! specification of organ identity
is_a: GO:0060423 ! foregut regionalization
relationship: part_of GO:0060431 ! primary lung bud formation

[Term]
id: GO:0060425
name: lung morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the lung are generated and organized." [GOC:dph]
is_a: GO:0009887 ! organ morphogenesis
relationship: part_of GO:0030324 ! lung development

[Term]
id: GO:0060426
name: lung vasculature development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a lung vasculature from an initial condition to its mature state. This process begins with the formation of the lung vasculature and ends with the mature structure. The lung vasculature is composed of the tubule structures that carry blood or lymph in the lungs." [GOC:dph, GOC:mtg_lung]
synonym: "pulmonary vasculature development" EXACT [GOC:dph, GOC:mtg_lung]
is_a: GO:0001944 ! vasculature development
relationship: part_of GO:0030324 ! lung development

[Term]
id: GO:0060427
name: lung connective tissue development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of lung connective tissue from an initial condition to its mature state. This process begins with the formation of lung connective tissue and ends with the mature structure. The lung connective tissue is a material made up of fibers forming a framework and support structure for the lungs." [GOC:dph, GOC:mtg_lung]
synonym: "pulmonary connective tissue development" EXACT []
is_a: GO:0061448 ! connective tissue development
relationship: part_of GO:0030324 ! lung development

[Term]
id: GO:0060428
name: lung epithelium development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of the lung epithelium from an initial condition to its mature state. This process begins with the formation of lung epithelium and ends with the mature structure. The lung epithelium is the specialized epithelium that lines the inside of the lung." [GOC:dph, GOC:mtg_lung]
synonym: "pulmonary epithelium development" EXACT [GOC:dph, GOC:mtg_lung]
is_a: GO:0060429 ! epithelium development
relationship: part_of GO:0030324 ! lung development

[Term]
id: GO:0060429
name: epithelium development
namespace: biological_process
def: "The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:dph, GOC:mtg_lung]
is_a: GO:0009888 ! tissue development

[Term]
id: GO:0060430
name: lung saccule development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a lung saccule from an initial condition to its mature state. The lung saccule is the primitive gas exchange portion of the lung composed of type I and type II cells." [GOC:dph, GOC:mtg_lung]
synonym: "lung saccular development" BROAD [GOC:dph]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048286 ! lung alveolus development

[Term]
id: GO:0060431
name: primary lung bud formation
namespace: biological_process
def: "The morphogenetic process in which the foregut region specified to become the lung forms the initial left and right buds." [GOC:dph, GOC:mtg_lung]
synonym: "lung formation" EXACT [GOC:dph]
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
is_a: GO:0048645 ! organ formation
is_a: GO:0060441 ! epithelial tube branching involved in lung morphogenesis
is_a: GO:0060572 ! morphogenesis of an epithelial bud

[Term]
id: GO:0060432
name: lung pattern specification process
namespace: biological_process
def: "Any developmental process that results in the creation of defined areas or spaces within the lung, to which cells respond and eventually are instructed to differentiate." [GOC:dph]
is_a: GO:0007389 ! pattern specification process
relationship: part_of GO:0030324 ! lung development

[Term]
id: GO:0060433
name: bronchus development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a bronchus from an initial condition to its mature state. This process begins with the formation of the bronchus and ends with the mature structure. The bronchus is the portion of the airway that connects to the lungs." [GOC:dph]
is_a: GO:0030323 ! respiratory tube development
relationship: part_of GO:0060541 ! respiratory system development

[Term]
id: GO:0060434
name: bronchus morphogenesis
namespace: biological_process
def: "The process in which the bronchus is generated and organized. The bronchus is the portion of the airway that connects to the lungs." [GOC:dph]
is_a: GO:0009887 ! organ morphogenesis
is_a: GO:0035239 ! tube morphogenesis
relationship: part_of GO:0060433 ! bronchus development

[Term]
id: GO:0060435
name: bronchiole development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a bronchiole from an initial condition to its mature state. This process begins with the formation of the bronchiole and ends with the mature structure. A bronchiole is the first airway branch that no longer contains cartilage; it is a branch of the bronchi." [GOC:dph, GOC:mtg_lung]
is_a: GO:0030323 ! respiratory tube development
relationship: part_of GO:0030324 ! lung development

[Term]
id: GO:0060436
name: bronchiole morphogenesis
namespace: biological_process
def: "The process in which a bronchiole is generated and organized. A bronchiole is the first airway branch that no longer contains cartilage; it is a branch of the bronchi." [GOC:dph]
is_a: GO:0035239 ! tube morphogenesis
relationship: part_of GO:0060435 ! bronchiole development

[Term]
id: GO:0060437
name: lung growth
namespace: biological_process
def: "The increase in size or mass of a lung. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax." [GOC:dph]
is_a: GO:0035265 ! organ growth
relationship: part_of GO:0030324 ! lung development

[Term]
id: GO:0060438
name: trachea development
namespace: biological_process
def: "The process whose specific outcome is the progression of a trachea over time, from its formation to the mature structure. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048513 ! animal organ development
relationship: part_of GO:0060541 ! respiratory system development

[Term]
id: GO:0060439
name: trachea morphogenesis
namespace: biological_process
def: "The process in which a trachea is generated and organized. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph]
is_a: GO:0009887 ! organ morphogenesis
relationship: part_of GO:0060438 ! trachea development

[Term]
id: GO:0060440
name: trachea formation
namespace: biological_process
def: "The process pertaining to the initial formation of a trachea from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the trachea is recognizable. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph]
is_a: GO:0048645 ! organ formation
relationship: part_of GO:0060439 ! trachea morphogenesis

[Term]
id: GO:0060441
name: epithelial tube branching involved in lung morphogenesis
namespace: biological_process
def: "The process in which a highly ordered sequence of patterning events generates the branched epithelial tubes of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units." [GOC:dph, GOC:mtg_lung]
synonym: "lung branching morphogenesis" EXACT [GOC:dph]
is_a: GO:0048754 ! branching morphogenesis of an epithelial tube
intersection_of: GO:0048754 ! branching morphogenesis of an epithelial tube
intersection_of: part_of GO:0060425 ! lung morphogenesis
relationship: part_of GO:0060425 ! lung morphogenesis

[Term]
id: GO:0060442
name: branching involved in prostate gland morphogenesis
namespace: biological_process
def: "The process in which the branching structure of the prostate gland is generated and organized. A branch is a division or offshoot from a main stem." [GOC:dph]
synonym: "prostate branching" RELATED [GOC:dph]
synonym: "prostate gland branching morphogenesis" EXACT [GOC:dph]
is_a: GO:0060740 ! prostate gland epithelium morphogenesis
is_a: GO:0061138 ! morphogenesis of a branching epithelium
intersection_of: GO:0061138 ! morphogenesis of a branching epithelium
intersection_of: part_of GO:0060512 ! prostate gland morphogenesis
relationship: part_of GO:0060512 ! prostate gland morphogenesis

[Term]
id: GO:0060443
name: mammary gland morphogenesis
namespace: biological_process
def: "The process in which anatomical structures of the mammary gland are generated and organized. Morphogenesis refers to the creation of shape. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk." [GOC:dph]
is_a: GO:0022612 ! gland morphogenesis
relationship: part_of GO:0030879 ! mammary gland development

[Term]
id: GO:0060444
name: branching involved in mammary gland duct morphogenesis
namespace: biological_process
def: "The process in which the branching structure of the mammary gland duct is generated and organized. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk." [GOC:dph]
synonym: "mammary gland branching morphogenesis" EXACT [GOC:dph]
is_a: GO:0048754 ! branching morphogenesis of an epithelial tube
intersection_of: GO:0061138 ! morphogenesis of a branching epithelium
intersection_of: part_of GO:0060603 ! mammary gland duct morphogenesis
relationship: part_of GO:0060603 ! mammary gland duct morphogenesis

[Term]
id: GO:0060445
name: branching involved in salivary gland morphogenesis
namespace: biological_process
def: "The process in which the branching structure of the salivary gland is generated and organized." [GOC:dph]
is_a: GO:0061138 ! morphogenesis of a branching epithelium
intersection_of: GO:0061138 ! morphogenesis of a branching epithelium
intersection_of: part_of GO:0007435 ! salivary gland morphogenesis
relationship: part_of GO:0007435 ! salivary gland morphogenesis

[Term]
id: GO:0060446
name: branching involved in open tracheal system development
namespace: biological_process
def: "The process in which the anatomical structures of branches in the open tracheal system are generated and organized." [GOC:dph]
is_a: GO:0048754 ! branching morphogenesis of an epithelial tube
intersection_of: GO:0048754 ! branching morphogenesis of an epithelial tube
intersection_of: part_of GO:0007424 ! open tracheal system development
relationship: part_of GO:0007424 ! open tracheal system development

[Term]
id: GO:0060447
name: bud outgrowth involved in lung branching
namespace: biological_process
def: "The process in which a region of the lung epithelium initiates an outgrowth." [GOC:dph, GOC:mtg_lung]
synonym: "bud formation involved in lung branching" EXACT [GOC:dph, GOC:mtg_lung]
is_a: GO:0060602 ! branch elongation of an epithelium
relationship: part_of GO:0060441 ! epithelial tube branching involved in lung morphogenesis

[Term]
id: GO:0060448
name: dichotomous subdivision of terminal units involved in lung branching
namespace: biological_process
def: "The process in which a lung bud bifurcates." [GOC:dph, GOC:mtg_lung]
synonym: "bud bifurcation involved in lung branching" EXACT [GOC:dph, GOC:mtg_lung]
is_a: GO:0060600 ! dichotomous subdivision of an epithelial terminal unit
intersection_of: GO:0060600 ! dichotomous subdivision of an epithelial terminal unit
intersection_of: part_of GO:0060441 ! epithelial tube branching involved in lung morphogenesis
relationship: part_of GO:0060441 ! epithelial tube branching involved in lung morphogenesis

[Term]
id: GO:0060449
name: bud elongation involved in lung branching
namespace: biological_process
def: "The process in which a bud in the lung grows out from the point where it is formed." [GOC:dph, GOC:mtg_lung]
is_a: GO:0060602 ! branch elongation of an epithelium
relationship: part_of GO:0060441 ! epithelial tube branching involved in lung morphogenesis

[Term]
id: GO:0060450
name: positive regulation of hindgut contraction
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine." [GOC:dph, GOC:tb]
is_a: GO:0043134 ! regulation of hindgut contraction
is_a: GO:0045987 ! positive regulation of smooth muscle contraction
is_a: GO:0060456 ! positive regulation of digestive system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043133 ! hindgut contraction
relationship: positively_regulates GO:0043133 ! hindgut contraction

[Term]
id: GO:0060451
name: negative regulation of hindgut contraction
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine." [GOC:dph, GOC:tb]
is_a: GO:0043134 ! regulation of hindgut contraction
is_a: GO:0045986 ! negative regulation of smooth muscle contraction
is_a: GO:0060457 ! negative regulation of digestive system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043133 ! hindgut contraction
relationship: negatively_regulates GO:0043133 ! hindgut contraction

[Term]
id: GO:0060452
name: positive regulation of cardiac muscle contraction
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of cardiac muscle contraction." [GOC:dph, GOC:tb]
is_a: GO:0045823 ! positive regulation of heart contraction
is_a: GO:0045989 ! positive regulation of striated muscle contraction
is_a: GO:0055117 ! regulation of cardiac muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060048 ! cardiac muscle contraction
relationship: positively_regulates GO:0060048 ! cardiac muscle contraction

[Term]
id: GO:0060453
name: regulation of gastric acid secretion
namespace: biological_process
def: "Any process that modulates the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion." [GOC:dph, GOC:tb]
is_a: GO:0044058 ! regulation of digestive system process
is_a: GO:0051046 ! regulation of secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001696 ! gastric acid secretion
relationship: regulates GO:0001696 ! gastric acid secretion

[Term]
id: GO:0060454
name: positive regulation of gastric acid secretion
namespace: biological_process
def: "Any process that increases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion." [GOC:dph, GOC:tb]
is_a: GO:0051047 ! positive regulation of secretion
is_a: GO:0060453 ! regulation of gastric acid secretion
is_a: GO:0060456 ! positive regulation of digestive system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001696 ! gastric acid secretion
relationship: positively_regulates GO:0001696 ! gastric acid secretion

[Term]
id: GO:0060455
name: negative regulation of gastric acid secretion
namespace: biological_process
def: "Any process that decreases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion." [GOC:dph, GOC:tb]
is_a: GO:0051048 ! negative regulation of secretion
is_a: GO:0060453 ! regulation of gastric acid secretion
is_a: GO:0060457 ! negative regulation of digestive system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001696 ! gastric acid secretion
relationship: negatively_regulates GO:0001696 ! gastric acid secretion

[Term]
id: GO:0060456
name: positive regulation of digestive system process
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:dph, GOC:tb]
is_a: GO:0044058 ! regulation of digestive system process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0022600 ! digestive system process
relationship: positively_regulates GO:0022600 ! digestive system process

[Term]
id: GO:0060457
name: negative regulation of digestive system process
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:dph, GOC:tb]
is_a: GO:0044058 ! regulation of digestive system process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0022600 ! digestive system process
relationship: negatively_regulates GO:0022600 ! digestive system process

[Term]
id: GO:0060458
name: right lung development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a right lung from an initial condition to its mature state. This process begins with the formation of the right lung and ends with the mature structure. The right lung is the lung which is on the right side of the anterior posterior axis looking from a dorsal to ventral aspect." [GOC:dph, GOC:mtg_lung]
synonym: "right pulmonary development" EXACT [GOC:dph, GOC:mtg_lung]
is_a: GO:0030324 ! lung development

[Term]
id: GO:0060459
name: left lung development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a left lung from an initial condition to its mature state. This process begins with the formation of the left lung and ends with the mature structure. The left lung is the lung which is on the left side of the anterior posterior axis looking from a dorsal to ventral aspect." [GOC:dph, GOC:mtg_lung]
synonym: "left pulmonary development" EXACT [GOC:dph]
is_a: GO:0030324 ! lung development

[Term]
id: GO:0060460
name: left lung morphogenesis
namespace: biological_process
def: "The process in which anatomical structures of the left lung are generated and organized." [GOC:dph]
is_a: GO:0060425 ! lung morphogenesis
relationship: part_of GO:0060459 ! left lung development

[Term]
id: GO:0060461
name: right lung morphogenesis
namespace: biological_process
def: "The process in which anatomical structures of the right lung are generated and organized." [GOC:dph, GOC:mtg_lung]
is_a: GO:0060425 ! lung morphogenesis
relationship: part_of GO:0060458 ! right lung development

[Term]
id: GO:0060462
name: lung lobe development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a lung lobe from an initial condition to its mature state. This process begins with the formation of a lung lobe by branching morphogenesis and ends with the mature structure. A lung lobe is one of the rounded projections that compose the lung." [GOC:dph]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0030324 ! lung development

[Term]
id: GO:0060463
name: lung lobe morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a lung lobe are generated and organized. A lung lobe is a projection that extends from the lung." [GOC:dph]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0060425 ! lung morphogenesis
relationship: part_of GO:0060462 ! lung lobe development

[Term]
id: GO:0060464
name: lung lobe formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a lung lobe from unspecified parts. This process begins with the specific processes that contribute to the appearance of the lobe and ends when the structural rudiment is recognizable. A lung lobe is a projection that extends from the lung." [GOC:dph]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0060463 ! lung lobe morphogenesis

[Term]
id: GO:0060465
name: pharynx development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a pharynx from an initial condition to its mature state. The pharynx is the part of the digestive system immediately posterior to the mouth." [GOC:dph, GOC:rk]
synonym: "pharyngeal development" RELATED []
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048565 ! digestive tract development

[Term]
id: GO:0060466
name: activation of meiosis involved in egg activation
namespace: biological_process
def: "Any process that starts the inactive process of meiosis in an egg after the egg has been fertilized or physiologically activated. Eggs generally arrest in meiosis and complete the process after activation." [GOC:dph]
synonym: "reactivation of meiosis after fertilization" NARROW [GOC:dph]
synonym: "resumption of meiosis involved in egg activation" EXACT [GOC:dph]
is_a: GO:0022414 ! reproductive process
is_a: GO:0090427 ! activation of meiosis
intersection_of: GO:0090427 ! activation of meiosis
intersection_of: part_of GO:0007343 ! egg activation
relationship: part_of GO:0007343 ! egg activation

[Term]
id: GO:0060467
name: negative regulation of fertilization
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." [GOC:dph]
is_a: GO:0043901 ! negative regulation of multi-organism process
is_a: GO:2000242 ! negative regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009566 ! fertilization
relationship: negatively_regulates GO:0009566 ! fertilization

[Term]
id: GO:0060468
name: prevention of polyspermy
namespace: biological_process
def: "The negative regulation of fertilization process that takes place as part of egg activation, ensuring that only a single sperm fertilizes the egg." [GOC:dph]
synonym: "negative regulation of fertilization involved in egg activation" EXACT [GOC:dph]
synonym: "polyspermy block" EXACT [GOC:dph]
is_a: GO:0022414 ! reproductive process
is_a: GO:0060467 ! negative regulation of fertilization
intersection_of: GO:0060467 ! negative regulation of fertilization
intersection_of: part_of GO:0007343 ! egg activation
relationship: part_of GO:0007343 ! egg activation

[Term]
id: GO:0060469
name: positive regulation of transcription involved in egg activation
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of transcription as a part of the process of egg activation." [GOC:dph]
synonym: "activation of the egg genome" RELATED [GOC:dph]
synonym: "activation of the maternal genome" RELATED [GOC:dph]
is_a: GO:0022414 ! reproductive process
is_a: GO:0045893 ! positive regulation of transcription, DNA-templated
intersection_of: GO:0045893 ! positive regulation of transcription, DNA-templated
intersection_of: part_of GO:0007343 ! egg activation
relationship: part_of GO:0007343 ! egg activation

[Term]
id: GO:0060470
name: positive regulation of cytosolic calcium ion concentration involved in egg activation
namespace: biological_process
def: "The process that increases the concentration of calcium ions in the cytosol after fertilization or the physiological activation of an egg." [GOC:dph]
synonym: "elevation of cytosolic calcium ion concentration involved in egg activation" EXACT []
is_a: GO:0007204 ! positive regulation of cytosolic calcium ion concentration
is_a: GO:0044702 ! single organism reproductive process
intersection_of: GO:0007204 ! positive regulation of cytosolic calcium ion concentration
intersection_of: part_of GO:0007343 ! egg activation
relationship: part_of GO:0007343 ! egg activation

[Term]
id: GO:0060471
name: cortical granule exocytosis
namespace: biological_process
def: "The process of secretion by a cell that results in the release of intracellular molecules contained within a cortical granule by fusion of the vesicle with the plasma membrane of a cell. A cortical granule is a specialized secretory vesicle that is released during egg activation that changes the surface of the egg to prevent polyspermy." [GOC:dph]
synonym: "cortical granule release" RELATED [GOC:dph]
is_a: GO:0017156 ! calcium ion regulated exocytosis
is_a: GO:0044702 ! single organism reproductive process
relationship: part_of GO:0060468 ! prevention of polyspermy

[Term]
id: GO:0060472
name: positive regulation of cortical granule exocytosis by positive regulation of cytosolic calcium ion concentration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cortical granule exocytosis by directing movement of calcium ions (Ca2+) into the cytosol." [GOC:dph]
synonym: "positive regulation of cortical granule exocytosis by elevation of cytosolic calcium ion concentration" EXACT []
is_a: GO:0043902 ! positive regulation of multi-organism process
is_a: GO:0045956 ! positive regulation of calcium ion-dependent exocytosis
is_a: GO:0050867 ! positive regulation of cell activation
is_a: GO:0060470 ! positive regulation of cytosolic calcium ion concentration involved in egg activation
is_a: GO:2000243 ! positive regulation of reproductive process
relationship: positively_regulates GO:0060471 ! cortical granule exocytosis

[Term]
id: GO:0060473
name: cortical granule
namespace: cellular_component
def: "A secretory vesicle that is stored under the cell membrane of an egg. These vesicles fuse with the egg plasma membrane as part of egg activation and are part of the block to polyspermy." [GOC:dph]
synonym: "cortical vesicle" RELATED [GOC:dph]
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0060474
name: positive regulation of sperm motility involved in capacitation
namespace: biological_process
def: "The process in which the controlled movement of a sperm cell is initiated as part of the process required for sperm to reach fertilization competence." [GOC:dph]
is_a: GO:0022414 ! reproductive process
is_a: GO:1902093 ! positive regulation of sperm motility
intersection_of: GO:1902093 ! positive regulation of sperm motility
intersection_of: part_of GO:0048240 ! sperm capacitation
relationship: part_of GO:0048240 ! sperm capacitation
relationship: positively_regulates GO:0030317 ! sperm motility

[Term]
id: GO:0060475
name: positive regulation of actin filament polymerization involved in acrosome reaction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of actin polymerization as part of the acrosome reaction." [GOC:dph]
synonym: "positive regulation of actin polymerization involved in acrosome reaction" RELATED [GOC:dph]
is_a: GO:0030838 ! positive regulation of actin filament polymerization
is_a: GO:0044702 ! single organism reproductive process
intersection_of: GO:0030838 ! positive regulation of actin filament polymerization
intersection_of: part_of GO:0007340 ! acrosome reaction
relationship: part_of GO:0007340 ! acrosome reaction

[Term]
id: GO:0060476
name: protein localization involved in acrosome reaction
namespace: biological_process
def: "The actin-based process in which a protein is transported to, or maintained in, a specific location in the sperm as part of the acrosome reaction." [GOC:dph]
synonym: "protein localisation involved in acrosome reaction" EXACT [GOC:mah]
is_a: GO:0008105 ! asymmetric protein localization
is_a: GO:0030029 ! actin filament-based process
is_a: GO:0034613 ! cellular protein localization
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:1902580 ! single-organism cellular localization
intersection_of: GO:0008104 ! protein localization
intersection_of: part_of GO:0007340 ! acrosome reaction
relationship: part_of GO:0007340 ! acrosome reaction

[Term]
id: GO:0060477
name: peptidyl-serine phosphorylation involved in acrosome reaction
namespace: biological_process
def: "The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine that is part of the acrosome reaction." [GOC:dph]
is_a: GO:0018105 ! peptidyl-serine phosphorylation
is_a: GO:0022414 ! reproductive process
intersection_of: GO:0018105 ! peptidyl-serine phosphorylation
intersection_of: part_of GO:0007340 ! acrosome reaction
relationship: part_of GO:0007340 ! acrosome reaction

[Term]
id: GO:0060478
name: acrosomal vesicle exocytosis
namespace: biological_process
def: "The release of intracellular molecules contained within the acrosomal granule by fusion of the vesicle with the plasma membrane of the oocyte, requiring calcium ions." [GOC:dph]
synonym: "acrosomal granule exocytosis" RELATED [GOC:dph]
synonym: "acrosome exocytosis" EXACT [GOC:dph]
is_a: GO:0017156 ! calcium ion regulated exocytosis
is_a: GO:0044702 ! single organism reproductive process
relationship: part_of GO:0007340 ! acrosome reaction

[Term]
id: GO:0060479
name: lung cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features of a mature cell found in the lung. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:dph, GOC:mtg_lung]
synonym: "pulmonary cell differentiation" EXACT [GOC:dph]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0030324 ! lung development

[Term]
id: GO:0060480
name: lung goblet cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a lung goblet cell. A goblet cell is a cell of the epithelial lining that produces and secretes mucins." [GOC:dph, GOC:mtg_lung]
synonym: "pulmonary goblet cell differentiation" EXACT []
is_a: GO:0002067 ! glandular epithelial cell differentiation
is_a: GO:0061140 ! lung secretory cell differentiation
relationship: part_of GO:0060481 ! lobar bronchus epithelium development

[Term]
id: GO:0060481
name: lobar bronchus epithelium development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a lobar bronchus epithelium from an initial condition to its mature state. This process begins with the formation of the lobar bronchus epithelium and ends with the mature structure. The lobar bronchus epithelium is the tissue made up of epithelial cells that lines the inside of the lobar bronchus." [GOC:dph, GOC:mtg_lung]
is_a: GO:0060428 ! lung epithelium development
relationship: part_of GO:0060482 ! lobar bronchus development

[Term]
id: GO:0060482
name: lobar bronchus development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a lobar bronchus from an initial condition to its mature state. This process begins with the formation of the lobar bronchus and ends with the mature structure. The lobar bronchus is the major airway within the respiratory tree that starts by division of the principal bronchi on both sides and ends at the point of its own subdivision into tertiary or segmental bronchi." [GOC:dph, GOC:mtg_lung]
is_a: GO:0060433 ! bronchus development

[Term]
id: GO:0060483
name: lobar bronchus mesenchyme development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a lobar bronchus mesenchyme from an initial condition to its mature state. This process begins with the formation of the lobar bronchus mesenchyme and ends with the mature structure. The lobar bronchus mesenchyme is the mass of tissue composed of mesenchymal cells in the lobar bronchus." [GOC:dph, GOC:mtg_lung]
is_a: GO:0060484 ! lung-associated mesenchyme development
relationship: part_of GO:0060482 ! lobar bronchus development

[Term]
id: GO:0060484
name: lung-associated mesenchyme development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a lung-associated mesenchyme from an initial condition to its mature state. This process begins with the formation of lung-associated mesenchyme and ends with the mature structure. Lung-associated mesenchyme is the tissue made up of loosely connected mesenchymal cells in the lung." [GOC:dph, GOC:mtg_lung]
synonym: "lung mesenchyme development" EXACT [GOC:dph]
synonym: "pulmonary mesenchyme development" EXACT [GOC:dph]
is_a: GO:0060485 ! mesenchyme development
relationship: part_of GO:0030324 ! lung development

[Term]
id: GO:0060485
name: mesenchyme development
namespace: biological_process
def: "The process whose specific outcome is the progression of a mesenchymal tissue over time, from its formation to the mature structure. A mesenchymal tissue is made up of loosely packed stellate cells." [GOC:dph]
synonym: "mesenchymal development" EXACT [GOC:dph]
is_a: GO:0009888 ! tissue development
relationship: part_of GO:0048513 ! animal organ development

[Term]
id: GO:0060486
name: Clara cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a Clara cell. A Clara cell is an unciliated epithelial cell found in the respiratory and terminal bronchioles." [GOC:dph, GOC:mtg_lung]
is_a: GO:0060487 ! lung epithelial cell differentiation

[Term]
id: GO:0060487
name: lung epithelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell that contributes to the epithelium of the lung." [GOC:dph]
synonym: "pulmonary epithelial cell differentiation" RELATED [GOC:dph]
is_a: GO:0030855 ! epithelial cell differentiation
is_a: GO:0060479 ! lung cell differentiation
relationship: part_of GO:0060428 ! lung epithelium development

[Term]
id: GO:0060488
name: orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis
namespace: biological_process
def: "The process in which a lung bud bifurcates perpendicular to the plane of the previous bud." [GOC:dph, GOC:mtg_lung]
synonym: "perpendicular dichotomous subdivision of terminal units involved in lung branching morphogenesis" EXACT [GOC:dph]
is_a: GO:0060448 ! dichotomous subdivision of terminal units involved in lung branching

[Term]
id: GO:0060489
name: planar dichotomous subdivision of terminal units involved in lung branching morphogenesis
namespace: biological_process
def: "The process in which a lung bud bifurcates parallel to the plane of the previous bud." [GOC:dph, GOC:mtg_lung]
is_a: GO:0060448 ! dichotomous subdivision of terminal units involved in lung branching

[Term]
id: GO:0060490
name: lateral sprouting involved in lung morphogenesis
namespace: biological_process
def: "The process in which a branch forms along the side of the lung epithelial tube." [GOC:dph, GOC:mtg_lung]
is_a: GO:0060601 ! lateral sprouting from an epithelium
intersection_of: GO:0060601 ! lateral sprouting from an epithelium
intersection_of: part_of GO:0060441 ! epithelial tube branching involved in lung morphogenesis
relationship: part_of GO:0060441 ! epithelial tube branching involved in lung morphogenesis

[Term]
id: GO:0060491
name: regulation of cell projection assembly
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of cell projection assembly." [GOC:dph, GOC:tb]
synonym: "regulation of cell projection formation" RELATED [GOC:dph, GOC:tb]
is_a: GO:0031344 ! regulation of cell projection organization
is_a: GO:0044087 ! regulation of cellular component biogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030031 ! cell projection assembly
relationship: regulates GO:0030031 ! cell projection assembly

[Term]
id: GO:0060492
name: lung induction
namespace: biological_process
def: "The close range interaction of two or more cells or tissues that causes the cells of the foregut to change their fates and specify the development of the lung." [GOC:dph]
is_a: GO:0001759 ! organ induction
is_a: GO:0040019 ! positive regulation of embryonic development
is_a: GO:0061047 ! positive regulation of branching involved in lung morphogenesis
intersection_of: GO:0001759 ! organ induction
intersection_of: positively_regulates GO:0060424 ! lung field specification
relationship: positively_regulates GO:0060424 ! lung field specification

[Term]
id: GO:0060493
name: mesenchymal-endodermal cell signaling involved in lung induction
namespace: biological_process
def: "Any process that mediates the transfer of information from a mesenchymal cell to an endodermal cell in the foregut and contributes to the formation of the lung bud." [GOC:dph, GOC:mtg_lung]
synonym: "mesenchymal-endodermal cell signalling involved in lung induction" EXACT [GOC:mah]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0060494 ! inductive mesenchymal-endodermal cell signaling
is_a: GO:0060496 ! mesenchymal-epithelial cell signaling involved in lung development
is_a: GO:0060497 ! mesenchymal-endodermal cell signaling
intersection_of: GO:0060497 ! mesenchymal-endodermal cell signaling
intersection_of: part_of GO:0060492 ! lung induction
relationship: part_of GO:0060492 ! lung induction

[Term]
id: GO:0060494
name: inductive mesenchymal-endodermal cell signaling
namespace: biological_process
def: "Any process that mediates the transfer of information from a mesenchymal cell to an endodermal cell changing the fate of the endodermal cell." [GOC:dph, GOC:mtg_lung]
synonym: "inductive mesenchymal-endodermal cell signalling" EXACT [GOC:mah]
is_a: GO:0031129 ! inductive cell-cell signaling

[Term]
id: GO:0060495
name: cell-cell signaling involved in lung development
namespace: biological_process
def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the lung, from its initial state to the mature structure." [GOC:dph, GOC:mtg_lung]
synonym: "cell-cell signalling involved in lung development" EXACT [GOC:mah]
is_a: GO:0007267 ! cell-cell signaling
intersection_of: GO:0007267 ! cell-cell signaling
intersection_of: part_of GO:0030324 ! lung development
relationship: part_of GO:0030324 ! lung development

[Term]
id: GO:0060496
name: mesenchymal-epithelial cell signaling involved in lung development
namespace: biological_process
def: "Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell and contributes to the development of the lung." [GOC:dph, GOC:mtg_lung]
synonym: "mesenchymal-epithelial cell signalling involved in lung development" EXACT [GOC:mah]
is_a: GO:0060495 ! cell-cell signaling involved in lung development
is_a: GO:0060638 ! mesenchymal-epithelial cell signaling
intersection_of: GO:0060638 ! mesenchymal-epithelial cell signaling
intersection_of: part_of GO:0030324 ! lung development
relationship: part_of GO:0030324 ! lung development

[Term]
id: GO:0060497
name: mesenchymal-endodermal cell signaling
namespace: biological_process
def: "Any process that mediates the transfer of information between a mesenchymal cell and an endodermal cell." [GOC:dph]
synonym: "mesenchymal-endodermal cell signalling" EXACT [GOC:mah]
is_a: GO:0060638 ! mesenchymal-epithelial cell signaling

[Term]
id: GO:0060498
name: retinoic acid receptor signaling pathway involved in lung bud formation
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands contributing to the formation of the primary lung bud." [GOC:dph, GOC:mtg_lung]
synonym: "retinoic acid receptor signalling pathway involved in lung bud formation" EXACT [GOC:mah]
is_a: GO:0048384 ! retinoic acid receptor signaling pathway
relationship: part_of GO:0060431 ! primary lung bud formation

[Term]
id: GO:0060499
name: fibroblast growth factor receptor signaling pathway involved in lung induction
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a fibroblast growth factor-type receptor binding to one of its physiological ligands resulting in the formation of the lung bud along the lateral-esophageal sulcus." [GOC:dph, GOC:mtg_lung]
synonym: "fibroblast growth factor receptor signalling pathway involved in lung induction" EXACT [GOC:mah]
is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway
is_a: GO:0031131 ! reception of an inductive signal
is_a: GO:1905114 ! cell surface receptor signaling pathway involved in cell-cell signaling
intersection_of: GO:0008543 ! fibroblast growth factor receptor signaling pathway
intersection_of: part_of GO:0060492 ! lung induction
relationship: part_of GO:0060492 ! lung induction
relationship: part_of GO:0060493 ! mesenchymal-endodermal cell signaling involved in lung induction

[Term]
id: GO:0060500
name: regulation of transcription from RNA polymerase II promoter involved in lung bud formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the branching morphogenesis by which the initial primordium of the lung is formed." [GOC:dph, GOC:mtg_lung]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
relationship: part_of GO:0060431 ! primary lung bud formation

[Term]
id: GO:0060501
name: positive regulation of epithelial cell proliferation involved in lung morphogenesis
namespace: biological_process
def: "Any process that increases the rate or frequency of epithelial cell proliferation that results in the lung attaining its shape." [GOC:dph]
is_a: GO:0050679 ! positive regulation of epithelial cell proliferation
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000794 ! regulation of epithelial cell proliferation involved in lung morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060502 ! epithelial cell proliferation involved in lung morphogenesis
relationship: positively_regulates GO:0060502 ! epithelial cell proliferation involved in lung morphogenesis

[Term]
id: GO:0060502
name: epithelial cell proliferation involved in lung morphogenesis
namespace: biological_process
def: "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the lung." [GOC:dph]
is_a: GO:0050673 ! epithelial cell proliferation
intersection_of: GO:0050673 ! epithelial cell proliferation
intersection_of: part_of GO:0060425 ! lung morphogenesis
relationship: part_of GO:0060425 ! lung morphogenesis
relationship: part_of GO:0060428 ! lung epithelium development

[Term]
id: GO:0060503
name: bud dilation involved in lung branching
namespace: biological_process
def: "The process in which a bud in the lung increases radially." [GOC:dph]
synonym: "bud expansion" EXACT [GOC:dph]
is_a: GO:0003401 ! axis elongation
relationship: part_of GO:0060441 ! epithelial tube branching involved in lung morphogenesis

[Term]
id: GO:0060504
name: positive regulation of epithelial cell proliferation involved in lung bud dilation
namespace: biological_process
def: "Any process that increases the rate or frequency of epithelial cell proliferation that results in the lung bud increasing in size radially." [GOC:dph]
is_a: GO:0048639 ! positive regulation of developmental growth
is_a: GO:0060501 ! positive regulation of epithelial cell proliferation involved in lung morphogenesis
is_a: GO:0061047 ! positive regulation of branching involved in lung morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060505 ! epithelial cell proliferation involved in lung bud dilation
relationship: positively_regulates GO:0060505 ! epithelial cell proliferation involved in lung bud dilation

[Term]
id: GO:0060505
name: epithelial cell proliferation involved in lung bud dilation
namespace: biological_process
def: "The multiplication or reproduction of epithelial cells that contribute to the radial growth of a lung bud." [GOC:dph]
is_a: GO:0060502 ! epithelial cell proliferation involved in lung morphogenesis
intersection_of: GO:0050673 ! epithelial cell proliferation
intersection_of: part_of GO:0060503 ! bud dilation involved in lung branching
relationship: part_of GO:0060503 ! bud dilation involved in lung branching

[Term]
id: GO:0060506
name: smoothened signaling pathway involved in lung development
namespace: biological_process
def: "The series of molecular signals generated as a consequence of activation of the transmembrane Smoothened-type protein. This process contributes to lung development." [GOC:dph, GOC:mtg_lung]
synonym: "hedgehog signaling pathway involved in lung development" EXACT [GOC:bf, GOC:ecd]
synonym: "hh signaling pathway involved in lung development" EXACT [GOC:bf, GOC:ecd]
synonym: "smoothened signalling pathway involved in lung development" EXACT [GOC:mah]
is_a: GO:0007224 ! smoothened signaling pathway
is_a: GO:1905114 ! cell surface receptor signaling pathway involved in cell-cell signaling
intersection_of: GO:0007224 ! smoothened signaling pathway
intersection_of: part_of GO:0030324 ! lung development
relationship: part_of GO:0030324 ! lung development
relationship: part_of GO:0060495 ! cell-cell signaling involved in lung development

[Term]
id: GO:0060507
name: epidermal growth factor receptor signaling pathway involved in lung development
namespace: biological_process
def: "The series of molecular signals generated as a consequence of an epidermal growth factor-type receptor binding to one of its physiological ligands. This process contributes to lung development." [GOC:dph, GOC:mtg_lung]
synonym: "epidermal growth factor receptor signalling pathway involved in lung development" EXACT [GOC:mah]
is_a: GO:0007173 ! epidermal growth factor receptor signaling pathway
is_a: GO:1905114 ! cell surface receptor signaling pathway involved in cell-cell signaling
intersection_of: GO:0007173 ! epidermal growth factor receptor signaling pathway
intersection_of: part_of GO:0030324 ! lung development
relationship: part_of GO:0030324 ! lung development
relationship: part_of GO:0060495 ! cell-cell signaling involved in lung development

[Term]
id: GO:0060508
name: lung basal cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features of a mature basal cell found in the lung. Differentiation includes the processes involved in commitment of a cell to a specific fate. A basal cell is an epithelial stem cell." [GOC:dph, GOC:mtg_lung]
synonym: "pulmonary basal cell differentiation" BROAD [GOC:dph, GOC:mtg_lung]
is_a: GO:0060479 ! lung cell differentiation
relationship: part_of GO:0060428 ! lung epithelium development

[Term]
id: GO:0060509
name: Type I pneumocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a Type I pneumocyte. A type I pneumocyte is a flattened cell with greatly attenuated cytoplasm and a paucity of organelles." [GOC:dph, GOC:mtg_lung, ISBN:0721662544]
synonym: "membranous pneumocyte differentiation" EXACT [GOC:dph, ISBN:0721662544]
synonym: "small alveolar cell differentiation" RELATED [GOC:dph, ISBN:0721662544]
synonym: "squamous alveolar cell differentiation" RELATED [GOC:dph, ISBN:0721662544]
is_a: GO:0060487 ! lung epithelial cell differentiation

[Term]
id: GO:0060510
name: Type II pneumocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a Type II pneumocyte. A Type II pneumocyte is a surfactant secreting cell that contains abundant cytoplasm containing numerous lipid-rich multilamellar bodies." [GOC:dph, GOC:mtg_lung, ISBN:0721662544]
synonym: "granular pneumocyte differentiation" RELATED [GOC:dph, ISBN:0721662544]
synonym: "great alveolar cell differentiation" EXACT [GOC:dph, ISBN:0721662544]
synonym: "large alveolar cell differentiation" RELATED [GOC:dph, ISBN:0721662544]
is_a: GO:0061140 ! lung secretory cell differentiation

[Term]
id: GO:0060511
name: creation of an inductive signal by a mesenchymal cell involved in lung induction
namespace: biological_process
def: "The process in which splanchnic mesenchymal cells send a signal over a short range to endodermal cells inducing them to form the primary lung bud." [GOC:dph, GOC:mtg_lung]
is_a: GO:0031130 ! creation of an inductive signal
relationship: part_of GO:0060493 ! mesenchymal-endodermal cell signaling involved in lung induction

[Term]
id: GO:0060512
name: prostate gland morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a prostate gland are generated and organized." [GOC:dph, PMID:18977204]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0022612 ! gland morphogenesis
is_a: GO:0044702 ! single organism reproductive process
relationship: part_of GO:0030850 ! prostate gland development

[Term]
id: GO:0060513
name: prostatic bud formation
namespace: biological_process
def: "The morphogenetic process in which a region of the fetal urogenital sinus epithelium is specified to become the prostate, resulting in prostate bud outgrowth." [GOC:dph, PMID:18977204]
synonym: "primary prostate bud formation" EXACT [GOC:dph]
synonym: "prostate ductal budding" EXACT [GOC:dph, PMID:11401393]
synonym: "prostate gland formation" EXACT [GOC:dph]
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
is_a: GO:0048645 ! organ formation
is_a: GO:0060572 ! morphogenesis of an epithelial bud
is_a: GO:0060601 ! lateral sprouting from an epithelium
is_a: GO:0060740 ! prostate gland epithelium morphogenesis

[Term]
id: GO:0060514
name: prostate induction
namespace: biological_process
def: "The close range interaction of the urogenital sinus mesenchyme and the urogenital sinus epithelium that causes the cells of the urogenital sinus epithelium to change their fates and specify the development of the prostate gland." [GOC:dph, PMID:18977204]
is_a: GO:0001759 ! organ induction
is_a: GO:0040019 ! positive regulation of embryonic development
is_a: GO:0060685 ! regulation of prostatic bud formation
is_a: GO:2000243 ! positive regulation of reproductive process
intersection_of: GO:0001759 ! organ induction
intersection_of: positively_regulates GO:0060515 ! prostate field specification
relationship: positively_regulates GO:0060515 ! prostate field specification

[Term]
id: GO:0060515
name: prostate field specification
namespace: biological_process
def: "The process that results in the delineation of a specific region of the urogenital sinus epithelium into the area in which the prostate gland will develop." [GOC:dph, PMID:18977204]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0010092 ! specification of organ identity
is_a: GO:0044702 ! single organism reproductive process
relationship: part_of GO:0060513 ! prostatic bud formation

[Term]
id: GO:0060516
name: primary prostatic bud elongation
namespace: biological_process
def: "The increase in size of the prostatic bud as it forms." [GOC:dph, PMID:18977204]
synonym: "prostate bud elongation" BROAD [GOC:dph]
synonym: "prostate bud elongation involved in prostate morphogenesis" EXACT [GOC:dph]
is_a: GO:0060602 ! branch elongation of an epithelium
is_a: GO:0060737 ! prostate gland morphogenetic growth
is_a: GO:0060740 ! prostate gland epithelium morphogenesis

[Term]
id: GO:0060517
name: epithelial cell proliferation involved in prostatic bud elongation
namespace: biological_process
def: "The multiplication of epithelial cells, contributing to the expansion of the primary prostatic bud." [GOC:dph, PMID:18977204]
is_a: GO:0060767 ! epithelial cell proliferation involved in prostate gland development
intersection_of: GO:0050673 ! epithelial cell proliferation
intersection_of: part_of GO:0060516 ! primary prostatic bud elongation
relationship: part_of GO:0060516 ! primary prostatic bud elongation

[Term]
id: GO:0060518
name: cell migration involved in prostatic bud elongation
namespace: biological_process
def: "The orderly movement of epithelial cells from one site to another contributing to the elongation of the primary prostatic bud." [GOC:dph, PMID:18977204]
is_a: GO:0010631 ! epithelial cell migration
is_a: GO:0044702 ! single organism reproductive process
intersection_of: GO:0010631 ! epithelial cell migration
intersection_of: part_of GO:0060516 ! primary prostatic bud elongation
relationship: part_of GO:0060516 ! primary prostatic bud elongation

[Term]
id: GO:0060519
name: cell adhesion involved in prostatic bud elongation
namespace: biological_process
def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the elongation of the primary prostatic bud." [GOC:dph, PMID:18977204]
is_a: GO:0007155 ! cell adhesion
is_a: GO:0022414 ! reproductive process
relationship: part_of GO:0060516 ! primary prostatic bud elongation

[Term]
id: GO:0060520
name: activation of prostate induction by androgen receptor signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of an androgen binding to its receptor in the urogenital sinus mesenchyme that initiates prostate induction. Prostate induction is the close range interaction of the urogenital sinus mesenchyme and the urogenital sinus epithelium that causes the cells of the urogenital sinus epithelium to change their fates and specify the development of the prostate gland." [GOC:dph, GOC:tb, PMID:18977204]
synonym: "activation of prostate induction by androgen receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0010455 ! positive regulation of cell fate commitment
is_a: GO:0010647 ! positive regulation of cell communication
is_a: GO:0023056 ! positive regulation of signaling
is_a: GO:0030521 ! androgen receptor signaling pathway
is_a: GO:0042659 ! regulation of cell fate specification
is_a: GO:0060685 ! regulation of prostatic bud formation
relationship: positively_regulates GO:0060514 ! prostate induction

[Term]
id: GO:0060521
name: mesenchymal-epithelial cell signaling involved in prostate induction
namespace: biological_process
def: "Signaling at short range from urogenital sinus mesenchymal cells to cells of the urogenital epithelium resulting in the epithelial cells adopting a prostatic fate." [GOC:dph, PMID:18977204]
synonym: "mesenchymal-epithelial cell signalling involved in prostate induction" EXACT [GOC:mah]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0060522 ! inductive mesenchymal to epithelial cell signaling
is_a: GO:0060739 ! mesenchymal-epithelial cell signaling involved in prostate gland development
intersection_of: GO:0060638 ! mesenchymal-epithelial cell signaling
intersection_of: part_of GO:0060514 ! prostate induction
relationship: part_of GO:0060514 ! prostate induction

[Term]
id: GO:0060522
name: inductive mesenchymal to epithelial cell signaling
namespace: biological_process
def: "Signaling at short range from mesenchymal cells to cells of an epithelium that results in a developmental change in the epithelial cells." [GOC:dph]
synonym: "inductive mesenchymal to epithelial cell signalling" EXACT [GOC:mah]
is_a: GO:0031129 ! inductive cell-cell signaling

[Term]
id: GO:0060523
name: prostate epithelial cord elongation
namespace: biological_process
def: "The developmental growth process in which solid chords of prostate epithelium increase in length." [GOC:dph, PMID:18977204]
is_a: GO:0060602 ! branch elongation of an epithelium
is_a: GO:0060737 ! prostate gland morphogenetic growth
is_a: GO:0060740 ! prostate gland epithelium morphogenesis
relationship: part_of GO:0060442 ! branching involved in prostate gland morphogenesis

[Term]
id: GO:0060524
name: dichotomous subdivision of prostate epithelial cord terminal unit
namespace: biological_process
def: "The process in which a prostate epithelial cord bifurcates at its end." [GOC:dph, PMID:18977204]
synonym: "prostate epithelial cord bifurcation" EXACT [GOC:dph]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0060600 ! dichotomous subdivision of an epithelial terminal unit
relationship: part_of GO:0060442 ! branching involved in prostate gland morphogenesis

[Term]
id: GO:0060525
name: prostate glandular acinus development
namespace: biological_process
def: "The progression of a glandular acinus of the prostate gland over time, from its initial formation to the mature structure. The glandular acini are the saclike structures of the gland." [GOC:dph, PMID:18977204]
is_a: GO:0048608 ! reproductive structure development
relationship: part_of GO:0030850 ! prostate gland development

[Term]
id: GO:0060526
name: prostate glandular acinus morphogenesis
namespace: biological_process
def: "The process in which the prostate glandular acini are generated and organized. The glandular acini are the saclike structures of the gland." [GOC:dph]
is_a: GO:0060740 ! prostate gland epithelium morphogenesis
relationship: part_of GO:0060525 ! prostate glandular acinus development

[Term]
id: GO:0060527
name: prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
namespace: biological_process
def: "The branching morphogenesis process in which the prostate epithelial cords branch freely to create the structure of the prostate acini." [GOC:dph, PMID:18977204]
is_a: GO:0060442 ! branching involved in prostate gland morphogenesis
relationship: part_of GO:0060526 ! prostate glandular acinus morphogenesis

[Term]
id: GO:0060528
name: secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
namespace: biological_process
def: "The process in which a relatively unspecialized epithelial cell acquires specialized features of a secretory columnal luminar epithelial cell of the prostate." [GOC:dph, PMID:18977204]
is_a: GO:0002067 ! glandular epithelial cell differentiation
is_a: GO:0060742 ! epithelial cell differentiation involved in prostate gland development
relationship: part_of GO:0060525 ! prostate glandular acinus development

[Term]
id: GO:0060529
name: squamous basal epithelial stem cell differentiation involved in prostate gland acinus development
namespace: biological_process
def: "The process in which a relatively unspecialized epithelial cell acquires specialized features of a squamous basal epithelial stem cell of the prostate." [GOC:dph, PMID:18977204]
is_a: GO:0002067 ! glandular epithelial cell differentiation
is_a: GO:0048863 ! stem cell differentiation
is_a: GO:0060742 ! epithelial cell differentiation involved in prostate gland development
relationship: part_of GO:0060525 ! prostate glandular acinus development

[Term]
id: GO:0060530
name: smooth muscle cell differentiation involved in prostate glandular acinus development
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell of the prostate glandular acinus." [GOC:dph, PMID:18977204]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0051145 ! smooth muscle cell differentiation
intersection_of: GO:0051145 ! smooth muscle cell differentiation
intersection_of: part_of GO:0060525 ! prostate glandular acinus development
relationship: part_of GO:0060525 ! prostate glandular acinus development

[Term]
id: GO:0060531
name: neuroendocrine cell differentiation involved in prostate gland acinus development
namespace: biological_process
def: "The process in which relatively unspecialized cells acquires specialized structural and functions of a neuroendocrine cell of the prostate gland acinus." [GOC:dph, PMID:18977204]
is_a: GO:0060742 ! epithelial cell differentiation involved in prostate gland development
is_a: GO:0061101 ! neuroendocrine cell differentiation
intersection_of: GO:0061101 ! neuroendocrine cell differentiation
intersection_of: part_of GO:0060525 ! prostate glandular acinus development
relationship: part_of GO:0060525 ! prostate glandular acinus development

[Term]
id: GO:0060532
name: bronchus cartilage development
namespace: biological_process
def: "The process whose specific outcome is the progression of lung cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph, GOC:mtg_lung]
synonym: "pulmonary cartilage development" EXACT []
is_a: GO:0051216 ! cartilage development
is_a: GO:0061448 ! connective tissue development
relationship: part_of GO:0060433 ! bronchus development
created_by: dph
creation_date: 2009-04-10T08:12:06Z

[Term]
id: GO:0060533
name: bronchus cartilage morphogenesis
namespace: biological_process
def: "The process in which the bronchus cartilage is generated and organized. The bronchus cartilage is the connective tissue of the portion of the airway that connects to the lungs." [GOC:dph]
is_a: GO:0060536 ! cartilage morphogenesis
relationship: part_of GO:0060434 ! bronchus morphogenesis
relationship: part_of GO:0060532 ! bronchus cartilage development
created_by: dph
creation_date: 2009-04-10T08:47:41Z

[Term]
id: GO:0060534
name: trachea cartilage development
namespace: biological_process
def: "The process whose specific outcome is the progression of the tracheal cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph]
is_a: GO:0051216 ! cartilage development
relationship: part_of GO:0060438 ! trachea development
created_by: dph
creation_date: 2009-04-10T09:00:18Z

[Term]
id: GO:0060535
name: trachea cartilage morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of cartilage in the trachea are generated and organized." [GOC:dph]
is_a: GO:0060536 ! cartilage morphogenesis
relationship: part_of GO:0060439 ! trachea morphogenesis
relationship: part_of GO:0060534 ! trachea cartilage development
created_by: dph
creation_date: 2009-04-10T09:07:48Z

[Term]
id: GO:0060536
name: cartilage morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of cartilage are generated and organized." [GOC:dph]
is_a: GO:0009887 ! organ morphogenesis
is_a: GO:0048729 ! tissue morphogenesis
relationship: part_of GO:0051216 ! cartilage development
created_by: dph
creation_date: 2009-04-10T09:13:27Z

[Term]
id: GO:0060537
name: muscle tissue development
namespace: biological_process
def: "The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers." [GOC:dph]
is_a: GO:0009888 ! tissue development
created_by: dph
creation_date: 2009-04-10T08:05:37Z

[Term]
id: GO:0060538
name: skeletal muscle organ development
namespace: biological_process
def: "The progression of a skeletal muscle organ over time from its initial formation to its mature state. A skeletal muscle organ includes the skeletal muscle tissue and its associated connective tissue." [GOC:dph]
is_a: GO:0007517 ! muscle organ development
created_by: dph
creation_date: 2009-04-10T08:25:12Z

[Term]
id: GO:0060539
name: diaphragm development
namespace: biological_process
def: "The progression of the diaphragm over time from its initial formation to the mature structure. The diaphragm is a skeletal muscle that is responsible for contraction and expansion of the lungs." [GOC:dph]
is_a: GO:0060538 ! skeletal muscle organ development
relationship: part_of GO:0060541 ! respiratory system development
created_by: dph
creation_date: 2009-04-10T08:44:56Z

[Term]
id: GO:0060540
name: diaphragm morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the diaphragm are generated and organized." [GOC:dph]
is_a: GO:0048644 ! muscle organ morphogenesis
relationship: part_of GO:0060539 ! diaphragm development
created_by: dph
creation_date: 2009-04-10T08:47:51Z

[Term]
id: GO:0060541
name: respiratory system development
namespace: biological_process
def: "The progression of the respiratory system over time from its formation to its mature structure. The respiratory system carries out respiratory gaseous exchange." [GOC:dph]
is_a: GO:0048731 ! system development
created_by: dph
creation_date: 2009-04-10T08:55:42Z

[Term]
id: GO:0060542
name: regulation of strand invasion
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of strand invasion. Strand invasion is the process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules." [GOC:dph, GOC:tb]
is_a: GO:0000018 ! regulation of DNA recombination
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042148 ! strand invasion
relationship: regulates GO:0042148 ! strand invasion
created_by: dph
creation_date: 2009-04-13T01:28:41Z

[Term]
id: GO:0060543
name: negative regulation of strand invasion
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of strand invasion. Strand invasion is the process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules." [GOC:dph, GOC:elh, GOC:tb]
synonym: "negative regulation of D-loop biosynthesis" RELATED [GOC:elh]
synonym: "negative regulation of D-loop formation" RELATED [GOC:elh]
synonym: "negative regulation of Rad51-mediated strand invasion" EXACT [GOC:elh]
is_a: GO:0045910 ! negative regulation of DNA recombination
is_a: GO:0060542 ! regulation of strand invasion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042148 ! strand invasion
relationship: negatively_regulates GO:0042148 ! strand invasion
created_by: dph
creation_date: 2009-04-13T01:32:36Z

[Term]
id: GO:0060544
name: regulation of necroptotic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of a necroptotic process, a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors." [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:tb]
synonym: "regulation of necroptosis" NARROW []
is_a: GO:0010939 ! regulation of necrotic cell death
is_a: GO:0043067 ! regulation of programmed cell death
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070266 ! necroptotic process
relationship: regulates GO:0070266 ! necroptotic process
created_by: dph
creation_date: 2009-04-13T01:43:22Z

[Term]
id: GO:0060545
name: positive regulation of necroptotic process
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of a necroptotic process, a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors." [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:tb]
synonym: "positive regulation of necroptosis" NARROW []
is_a: GO:0010940 ! positive regulation of necrotic cell death
is_a: GO:0043068 ! positive regulation of programmed cell death
is_a: GO:0060544 ! regulation of necroptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070266 ! necroptotic process
relationship: positively_regulates GO:0070266 ! necroptotic process
created_by: dph
creation_date: 2009-04-13T01:47:27Z

[Term]
id: GO:0060546
name: negative regulation of necroptotic process
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of a necroptotic process, a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors." [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:tb]
synonym: "negative regulation of necroptosis" NARROW []
is_a: GO:0043069 ! negative regulation of programmed cell death
is_a: GO:0060544 ! regulation of necroptotic process
is_a: GO:0060547 ! negative regulation of necrotic cell death
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070266 ! necroptotic process
relationship: negatively_regulates GO:0070266 ! necroptotic process
created_by: dph
creation_date: 2009-04-13T01:49:36Z

[Term]
id: GO:0060547
name: negative regulation of necrotic cell death
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010939 ! regulation of necrotic cell death
is_a: GO:0060548 ! negative regulation of cell death
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070265 ! necrotic cell death
relationship: negatively_regulates GO:0070265 ! necrotic cell death
created_by: dph
creation_date: 2009-04-13T01:51:25Z

[Term]
id: GO:0060548
name: negative regulation of cell death
namespace: biological_process
def: "Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010941 ! regulation of cell death
is_a: GO:0048523 ! negative regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008219 ! cell death
relationship: negatively_regulates GO:0008219 ! cell death
created_by: dph
creation_date: 2009-04-13T01:56:10Z

[Term]
id: GO:0060549
name: regulation of fructose 1,6-bisphosphate 1-phosphatase activity
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of fructose 1,6-bisphosphate 1-phosphatase activity. Fructose 1,6-bisphosphate 1-phosphatase activity is the catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0032113 ! regulation of carbohydrate phosphatase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042132 ! fructose 1,6-bisphosphate 1-phosphatase activity
relationship: regulates GO:0042132 ! fructose 1,6-bisphosphate 1-phosphatase activity
created_by: dph
creation_date: 2009-04-13T02:07:32Z

[Term]
id: GO:0060550
name: positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of fructose 1,6-bisphosphate 1-phosphatase activity. Fructose 1,6-bisphosphate 1-phosphatase activity is the catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010922 ! positive regulation of phosphatase activity
is_a: GO:0060549 ! regulation of fructose 1,6-bisphosphate 1-phosphatase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042132 ! fructose 1,6-bisphosphate 1-phosphatase activity
relationship: positively_regulates GO:0042132 ! fructose 1,6-bisphosphate 1-phosphatase activity
created_by: dph
creation_date: 2009-04-13T02:12:33Z

[Term]
id: GO:0060551
name: regulation of fructose 1,6-bisphosphate metabolic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of fructose 1,6-bisphosphate metabolism. Fructose 1,6-bisphosphate metabolism is the chemical reactions and pathways involving fructose 1,6-bisphosphate, also known as FBP. The D enantiomer is a metabolic intermediate in glycolysis and gluconeogenesis." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0019220 ! regulation of phosphate metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030388 ! fructose 1,6-bisphosphate metabolic process
relationship: regulates GO:0030388 ! fructose 1,6-bisphosphate metabolic process
created_by: dph
creation_date: 2009-04-13T02:20:04Z

[Term]
id: GO:0060552
name: positive regulation of fructose 1,6-bisphosphate metabolic process
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of fructose 1,6-bisphosphate metabolism. Fructose 1,6-bisphosphate metabolism is the chemical reactions and pathways involving fructose 1,6-bisphosphate, also known as FBP. The D enantiomer is a metabolic intermediate in glycolysis and gluconeogenesis." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0045937 ! positive regulation of phosphate metabolic process
is_a: GO:0060551 ! regulation of fructose 1,6-bisphosphate metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030388 ! fructose 1,6-bisphosphate metabolic process
relationship: positively_regulates GO:0030388 ! fructose 1,6-bisphosphate metabolic process
created_by: dph
creation_date: 2009-04-13T02:23:40Z

[Term]
id: GO:0060556
name: regulation of vitamin D biosynthetic process
namespace: biological_process
def: "Any process that modulates the rate frequency or extent of a vitamin D biosynthetic process. Vitamin D biosynthesis is the chemical reactions and pathways resulting in the formation of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)." [CHEBI:27300, GOC:BHF, GOC:mah, ISBN:0471331309]
is_a: GO:0030656 ! regulation of vitamin metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0050810 ! regulation of steroid biosynthetic process
is_a: GO:1902930 ! regulation of alcohol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042368 ! vitamin D biosynthetic process
relationship: regulates GO:0042368 ! vitamin D biosynthetic process
created_by: dph
creation_date: 2009-04-13T02:42:15Z

[Term]
id: GO:0060557
name: positive regulation of vitamin D biosynthetic process
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of a vitamin D biosynthetic process. Vitamin D biosynthesis is the chemical reactions and pathways resulting in the formation of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)." [CHEBI:27300, GOC:BHF, GOC:mah, ISBN:0471331309]
is_a: GO:0010893 ! positive regulation of steroid biosynthetic process
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0046136 ! positive regulation of vitamin metabolic process
is_a: GO:0060556 ! regulation of vitamin D biosynthetic process
is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042368 ! vitamin D biosynthetic process
relationship: positively_regulates GO:0042368 ! vitamin D biosynthetic process
created_by: dph
creation_date: 2009-04-13T02:46:14Z

[Term]
id: GO:0060558
name: regulation of calcidiol 1-monooxygenase activity
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of calcidiol 1-monooxygenase activity. Calcidiol 1-monooxygenase activity is catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0032768 ! regulation of monooxygenase activity
is_a: GO:0060556 ! regulation of vitamin D biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004498 ! calcidiol 1-monooxygenase activity
relationship: regulates GO:0004498 ! calcidiol 1-monooxygenase activity
created_by: dph
creation_date: 2009-04-13T02:52:18Z

[Term]
id: GO:0060559
name: positive regulation of calcidiol 1-monooxygenase activity
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of calcidiol 1-monooxygenase activity. Calcidiol 1-monooxygenase activity is the catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0032770 ! positive regulation of monooxygenase activity
is_a: GO:0060557 ! positive regulation of vitamin D biosynthetic process
is_a: GO:0060558 ! regulation of calcidiol 1-monooxygenase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004498 ! calcidiol 1-monooxygenase activity
relationship: positively_regulates GO:0004498 ! calcidiol 1-monooxygenase activity
created_by: dph
creation_date: 2009-04-13T02:57:28Z

[Term]
id: GO:0060560
name: developmental growth involved in morphogenesis
namespace: biological_process
def: "The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape." [GOC:dph]
synonym: "differential growth" EXACT [GOC:dph]
is_a: GO:0048589 ! developmental growth
intersection_of: GO:0048589 ! developmental growth
intersection_of: part_of GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0009653 ! anatomical structure morphogenesis
created_by: dph
creation_date: 2009-04-28T08:42:53Z

[Term]
id: GO:0060561
name: apoptotic process involved in morphogenesis
namespace: biological_process
def: "Any apoptotic process that contributes to the shaping of an anatomical structure." [GOC:dph, GOC:mtg_apoptosis]
synonym: "apoptosis involved in development" RELATED []
synonym: "apoptosis involved in morphogenesis" NARROW []
synonym: "morphogenetic apoptosis" RELATED [GOC:dph]
is_a: GO:0010623 ! developmental programmed cell death
is_a: GO:1902742 ! apoptotic process involved in development
intersection_of: GO:0006915 ! apoptotic process
intersection_of: part_of GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0009653 ! anatomical structure morphogenesis
created_by: dph
creation_date: 2009-04-28T09:17:27Z

[Term]
id: GO:0060562
name: epithelial tube morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a tube are generated and organized from an epithelium. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GOC:dph]
is_a: GO:0002009 ! morphogenesis of an epithelium
is_a: GO:0035239 ! tube morphogenesis
created_by: dph
creation_date: 2009-04-28T09:33:36Z

[Term]
id: GO:0060563
name: neuroepithelial cell differentiation
namespace: biological_process
def: "The process in which epiblast cells acquire specialized features of neuroepithelial cells." [GOC:dph, GOC:tb]
is_a: GO:0002065 ! columnar/cuboidal epithelial cell differentiation
created_by: dph
creation_date: 2009-04-29T01:50:05Z

[Term]
id: GO:0060564
name: negative regulation of APC-Cdc20 complex activity
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of APC-Cdc20 complex activity regulating mitotic cell cycle transitions." [GOC:dph, GOC:tb]
synonym: "negative regulation of anaphase-promoting complex activity during mitotic cell cycle" RELATED [GOC:dph, GOC:tb]
synonym: "negative regulation of APC activity during mitotic cell cycle" RELATED [GOC:dph, GOC:tb]
synonym: "negative regulation of APC/C activity during mitotic cell cycle" RELATED [GOC:dph, GOC:tb]
synonym: "negative regulation of cyclosome activity during mitotic cell cycle" RELATED [GOC:dph, GOC:tb]
synonym: "negative regulation of mitotic anaphase-promoting complex activity" RELATED [GOC:vw]
is_a: GO:0032435 ! negative regulation of proteasomal ubiquitin-dependent protein catabolic process
is_a: GO:0051436 ! negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
is_a: GO:1901990 ! regulation of mitotic cell cycle phase transition
relationship: negatively_regulates GO:0031145 ! anaphase-promoting complex-dependent catabolic process
created_by: dph
creation_date: 2009-04-29T02:11:19Z

[Term]
id: GO:0060565
name: obsolete inhibition of APC-Cdc20 complex activity
namespace: biological_process
def: "OBSOLETE. Any process that prevents the activation of APC-Cdc20 complex activity regulating the mitotic cell cycle." [GOC:dph, GOC:tb]
comment: This term was made obsolete because it was not clearly defined and thus used incorrectly in annotation.
synonym: "inhibition of APC activity during mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
synonym: "inhibition of APC-Cdc20 complex activity" EXACT []
synonym: "inhibition of APC/C activity during mitotic cell cycle" RELATED [GOC:dph, GOC:tb]
synonym: "inhibition of cyclosome activity during mitotic cell cycle" RELATED [GOC:dph, GOC:tb]
synonym: "inhibition of mitotic anaphase-promoting complex activity" RELATED [GOC:vw]
is_obsolete: true
consider: GO:0090645
created_by: dph
creation_date: 2009-04-29T02:29:31Z

[Term]
id: GO:0060566
name: positive regulation of DNA-templated transcription, termination
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of DNA-templated transcription termination, the process in which transcription is completed; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA." [GOC:dph, GOC:tb, GOC:txnOH]
synonym: "positive regulation of DNA-dependent transcription, termination" EXACT [GOC:txnOH]
synonym: "positive regulation of termination of DNA-dependent transcription" EXACT [GOC:jh2]
synonym: "positive regulation of transcription termination, DNA-dependent" EXACT [GOC:jh2]
is_a: GO:0031554 ! regulation of DNA-templated transcription, termination
is_a: GO:0043243 ! positive regulation of protein complex disassembly
is_a: GO:0045893 ! positive regulation of transcription, DNA-templated
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006353 ! DNA-templated transcription, termination
relationship: positively_regulates GO:0006353 ! DNA-templated transcription, termination
created_by: dph
creation_date: 2009-04-29T02:54:50Z

[Term]
id: GO:0060567
name: negative regulation of DNA-templated transcription, termination
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of DNA-dependent transcription termination, the process in which transcription is completed; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA." [GOC:dph, GOC:tb, GOC:txnOH]
synonym: "negative regulation of DNA-dependent transcription, termination" EXACT [GOC:txnOH]
synonym: "negative regulation of termination of DNA-dependent transcription" EXACT [GOC:jh2]
synonym: "negative regulation of transcription termination, DNA-dependent" EXACT [GOC:jh2]
is_a: GO:0031554 ! regulation of DNA-templated transcription, termination
is_a: GO:0043242 ! negative regulation of protein complex disassembly
is_a: GO:0045892 ! negative regulation of transcription, DNA-templated
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006353 ! DNA-templated transcription, termination
relationship: negatively_regulates GO:0006353 ! DNA-templated transcription, termination
created_by: dph
creation_date: 2009-04-29T02:59:12Z

[Term]
id: GO:0060568
name: regulation of peptide hormone processing
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of peptide hormone processing. Peptide hormone processing is the generation of a mature peptide hormone by posttranslational processing of a prohormone." [GOC:dph, GOC:tb]
is_a: GO:0032350 ! regulation of hormone metabolic process
is_a: GO:0034248 ! regulation of cellular amide metabolic process
is_a: GO:0070613 ! regulation of protein processing
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016486 ! peptide hormone processing
relationship: regulates GO:0016486 ! peptide hormone processing
created_by: dph
creation_date: 2009-04-29T03:16:05Z

[Term]
id: GO:0060569
name: positive regulation of peptide hormone processing
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of peptide hormone processing. Peptide hormone processing is the generation of a mature peptide hormone by posttranslational processing of a prohormone." [GOC:dph, GOC:tb]
is_a: GO:0010954 ! positive regulation of protein processing
is_a: GO:0032352 ! positive regulation of hormone metabolic process
is_a: GO:0034250 ! positive regulation of cellular amide metabolic process
is_a: GO:0060568 ! regulation of peptide hormone processing
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016486 ! peptide hormone processing
relationship: positively_regulates GO:0016486 ! peptide hormone processing
created_by: dph
creation_date: 2009-04-29T03:22:05Z

[Term]
id: GO:0060570
name: negative regulation of peptide hormone processing
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of peptide hormone processing. Peptide hormone processing is the generation of a mature peptide hormone by posttranslational processing of a prohormone." [GOC:dph, GOC:tb]
is_a: GO:0010955 ! negative regulation of protein processing
is_a: GO:0032351 ! negative regulation of hormone metabolic process
is_a: GO:0034249 ! negative regulation of cellular amide metabolic process
is_a: GO:0060568 ! regulation of peptide hormone processing
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016486 ! peptide hormone processing
relationship: negatively_regulates GO:0016486 ! peptide hormone processing
created_by: dph
creation_date: 2009-04-29T03:24:55Z

[Term]
id: GO:0060571
name: morphogenesis of an epithelial fold
namespace: biological_process
def: "The morphogenetic process in which an epithelial sheet bends along a linear axis." [GOC:dph]
synonym: "epithelial folding" EXACT [GOC:dph]
synonym: "folding of an epithelial sheet" RELATED [GOC:dph]
is_a: GO:0002009 ! morphogenesis of an epithelium
created_by: dph
creation_date: 2009-04-30T09:27:17Z

[Term]
id: GO:0060572
name: morphogenesis of an epithelial bud
namespace: biological_process
def: "The morphogenetic process in which a bud forms from an epithelial sheet. A bud is a protrusion that forms form the sheet by localized folding." [GOC:dph]
is_a: GO:0060571 ! morphogenesis of an epithelial fold
created_by: dph
creation_date: 2009-04-30T09:38:35Z

[Term]
id: GO:0060573
name: cell fate specification involved in pattern specification
namespace: biological_process
def: "The process involved in the specification of the identity of a cell in a field of cells that is being instructed as to how to differentiate. Once specification has taken place, that cell will be committed to differentiate down a specific pathway if left in its normal environment." [GOC:dph, GOC:tb]
is_a: GO:0001708 ! cell fate specification
intersection_of: GO:0001708 ! cell fate specification
intersection_of: part_of GO:0007389 ! pattern specification process
relationship: part_of GO:0007389 ! pattern specification process
relationship: part_of GO:0060581 ! cell fate commitment involved in pattern specification
created_by: dph
creation_date: 2009-05-05T02:19:14Z

[Term]
id: GO:0060574
name: intestinal epithelial cell maturation
namespace: biological_process
def: "The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell of the intestine to attain its fully functional state. A columnar/cuboidal epithelial cell of the intestine mature as they migrate from the intestinal crypt to the villus." [GOC:dph, PMID:18824147]
is_a: GO:0002069 ! columnar/cuboidal epithelial cell maturation
relationship: part_of GO:0060576 ! intestinal epithelial cell development
created_by: dph
creation_date: 2009-05-06T08:10:41Z

[Term]
id: GO:0060575
name: intestinal epithelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell of the intestine." [GOC:dph]
is_a: GO:0002065 ! columnar/cuboidal epithelial cell differentiation
relationship: part_of GO:0048565 ! digestive tract development
created_by: dph
creation_date: 2009-05-06T08:17:56Z

[Term]
id: GO:0060576
name: intestinal epithelial cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell of the intestine over time, from its formation to the mature structure." [GOC:dph]
is_a: GO:0002066 ! columnar/cuboidal epithelial cell development
relationship: part_of GO:0060575 ! intestinal epithelial cell differentiation
created_by: dph
creation_date: 2009-05-06T08:20:24Z

[Term]
id: GO:0060577
name: pulmonary vein morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the pulmonary venous blood vessels are generated and organized. Pulmonary veins are blood vessels that transport blood from the lungs to the heart." [GOC:dph]
synonym: "pulmonary venous blood vessel morphogenesis" RELATED [GOC:dph]
is_a: GO:0048845 ! venous blood vessel morphogenesis
created_by: dph
creation_date: 2009-05-06T08:44:04Z

[Term]
id: GO:0060578
name: superior vena cava morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of superior vena cava generated and organized. The superior vena cava is a blood vessel that transports blood from the upper body to the heart." [GOC:dph]
is_a: GO:0048845 ! venous blood vessel morphogenesis
created_by: dph
creation_date: 2009-05-06T08:47:21Z

[Term]
id: GO:0060579
name: ventral spinal cord interneuron fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a ventral spinal cord interneuron. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses." [GOC:dph]
is_a: GO:0048663 ! neuron fate commitment
is_a: GO:0060581 ! cell fate commitment involved in pattern specification
relationship: part_of GO:0021513 ! spinal cord dorsal/ventral patterning
relationship: part_of GO:0021514 ! ventral spinal cord interneuron differentiation
created_by: dph
creation_date: 2009-05-07T12:21:13Z

[Term]
id: GO:0060580
name: ventral spinal cord interneuron fate determination
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a ventral spinal cord interneuron regardless of its environment; upon determination, the cell fate cannot be reversed. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses." [GOC:dph]
is_a: GO:0048664 ! neuron fate determination
is_a: GO:0060582 ! cell fate determination involved in pattern specification
relationship: part_of GO:0060579 ! ventral spinal cord interneuron fate commitment
created_by: dph
creation_date: 2009-05-07T12:24:50Z

[Term]
id: GO:0060581
name: cell fate commitment involved in pattern specification
namespace: biological_process
def: "The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells within a field of cells that will exhibit a certain pattern of differentiation. Positional information is established through protein signals that emanate from a localized source within a developmental field resulting in specification of a cell type. Those signals are then interpreted in a cell-autonomous manner resulting in the determination of the cell type." [GOC:dph]
is_a: GO:0045165 ! cell fate commitment
intersection_of: GO:0045165 ! cell fate commitment
intersection_of: part_of GO:0007389 ! pattern specification process
relationship: part_of GO:0007389 ! pattern specification process
created_by: dph
creation_date: 2009-05-07T12:40:55Z

[Term]
id: GO:0060582
name: cell fate determination involved in pattern specification
namespace: biological_process
def: "A process involved in commitment of a cell to a fate in a developmental field. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [GOC:dph]
is_a: GO:0001709 ! cell fate determination
intersection_of: GO:0001709 ! cell fate determination
intersection_of: part_of GO:0007389 ! pattern specification process
relationship: part_of GO:0007389 ! pattern specification process
relationship: part_of GO:0060581 ! cell fate commitment involved in pattern specification
created_by: dph
creation_date: 2009-05-07T12:48:08Z

[Term]
id: GO:0060583
name: regulation of actin cortical patch localization
namespace: biological_process
def: "Any process that modulates the localization of an actin cortical patch. An actin cortical patch is a discrete actin-containing structure found just beneath the plasma membrane in fungal cells." [GOC:dph, GOC:tb]
synonym: "regulation of actin cortical patch localisation" EXACT [GOC:mah]
is_a: GO:0060341 ! regulation of cellular localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051666 ! actin cortical patch localization
relationship: regulates GO:0051666 ! actin cortical patch localization
created_by: dph
creation_date: 2009-05-08T01:58:42Z

[Term]
id: GO:0060584
name: regulation of prostaglandin-endoperoxide synthase activity
namespace: biological_process
def: "Any process that modulates the rate, frequency or prostaglandin-endoperoxide synthase activity. Prostaglandin-endoperoxide synthase activity is the catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "regulation of (PG)H synthase activity" EXACT [EC:1.14.99.1]
synonym: "regulation of fatty acid cyclooxygenase activity" EXACT [EC:1.14.99.1]
synonym: "regulation of PG synthetase activity" EXACT [EC:1.14.99.1]
synonym: "regulation of prostaglandin synthetase activity" EXACT [EC:1.14.99.1]
is_a: GO:0051341 ! regulation of oxidoreductase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004666 ! prostaglandin-endoperoxide synthase activity
relationship: regulates GO:0004666 ! prostaglandin-endoperoxide synthase activity
created_by: dph
creation_date: 2009-05-08T02:08:37Z

[Term]
id: GO:0060585
name: positive regulation of prostaglandin-endoperoxide synthase activity
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of prostaglandin-endoperoxide synthase activity. Prostaglandin-endoperoxide synthase activity is the catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "positive regulation of (PG)H synthase activity" EXACT [EC:1.14.99.1]
synonym: "positive regulation of fatty acid cyclooxygenase activity" EXACT [EC:1.14.99.1]
synonym: "positive regulation of PG synthetase activity" EXACT [EC:1.14.99.1]
synonym: "positive regulation of prostaglandin synthetase activity" EXACT [EC:1.14.99.1]
is_a: GO:0051353 ! positive regulation of oxidoreductase activity
is_a: GO:0060584 ! regulation of prostaglandin-endoperoxide synthase activity
relationship: positively_regulates GO:0004666 ! prostaglandin-endoperoxide synthase activity
created_by: dph
creation_date: 2009-05-08T02:12:34Z

[Term]
id: GO:0060586
name: multicellular organismal iron ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of the distribution of iron stores within tissues and organs of a multicellular organism." [GOC:dph, GOC:hjd, GOC:tb]
is_a: GO:0048871 ! multicellular organismal homeostasis
is_a: GO:0055072 ! iron ion homeostasis
created_by: dph
creation_date: 2009-05-08T02:18:21Z

[Term]
id: GO:0060587
name: regulation of lipoprotein lipid oxidation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of lipoprotein lipid oxidation. Lipoprotein lipid oxidation is the modification of a lipoprotein by oxidation of the lipid group." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0019216 ! regulation of lipid metabolic process
is_a: GO:0034442 ! regulation of lipoprotein oxidation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034439 ! lipoprotein lipid oxidation
relationship: regulates GO:0034439 ! lipoprotein lipid oxidation
created_by: dph
creation_date: 2009-05-08T02:27:02Z

[Term]
id: GO:0060588
name: negative regulation of lipoprotein lipid oxidation
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of lipoprotein lipid oxidation. Lipoprotein lipid oxidation is the modification of a lipoprotein by oxidation of the lipid group." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0034443 ! negative regulation of lipoprotein oxidation
is_a: GO:0045833 ! negative regulation of lipid metabolic process
is_a: GO:0060587 ! regulation of lipoprotein lipid oxidation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034439 ! lipoprotein lipid oxidation
relationship: negatively_regulates GO:0034439 ! lipoprotein lipid oxidation
created_by: dph
creation_date: 2009-05-08T02:30:49Z

[Term]
id: GO:0060589
name: nucleoside-triphosphatase regulator activity
namespace: molecular_function
def: "Modulates the rate of NTP hydrolysis by a NTPase." [GOC:dph, GOC:tb]
synonym: "NTPase regulator activity" EXACT [GOC:dph, GOC:tb]
is_a: GO:0030234 ! enzyme regulator activity
relationship: regulates GO:0017111 ! nucleoside-triphosphatase activity
created_by: dph
creation_date: 2009-05-08T02:49:24Z

[Term]
id: GO:0060590
name: ATPase regulator activity
namespace: molecular_function
def: "Modulates the rate of ATP hydrolysis by an ATPase." [GOC:dph, GOC:tb]
is_a: GO:0060589 ! nucleoside-triphosphatase regulator activity
relationship: regulates GO:0016887 ! ATPase activity
created_by: dph
creation_date: 2009-05-08T02:49:24Z

[Term]
id: GO:0060591
name: chondroblast differentiation
namespace: biological_process
def: "The process in which a mesenchymal cell, acquires specialized structural and/or functional features of a chondroblast. Differentiation includes the processes involved in commitment of a cell to a chondroblast fate. A chondroblast is a precursor cell to chondrocytes." [GOC:dph]
synonym: "chondrocyte progenitor cell differentiation" RELATED [GOC:dph]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0051216 ! cartilage development
created_by: dph
creation_date: 2009-05-11T07:47:36Z

[Term]
id: GO:0060592
name: mammary gland formation
namespace: biological_process
def: "The process pertaining to the initial formation of the mammary gland from unspecified parts. The process begins with formation of the mammary line and ends when the solid mammary bud invades the primary mammary mesenchyme." [GOC:dph, PMID:16168142, PMID:17120154]
synonym: "mammary bud formation" RELATED [GOC:dph]
synonym: "mammary line formation" NARROW [GOC:dph]
synonym: "mammary placode formation" NARROW [GOC:dph]
synonym: "mammary sprout formation" RELATED [GOC:dph]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0060443 ! mammary gland morphogenesis
created_by: dph
creation_date: 2009-05-13T08:47:52Z

[Term]
id: GO:0060593
name: Wnt signaling pathway involved in mammary gland specification
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a cell in the epidermis resulting in the formation of the mammary line. The mammary line is a ridge of epidermal cells that will form the mammary placodes." [GOC:dph, PMID:16168142]
synonym: "Wnt receptor signaling pathway involved in mammary gland specification" EXACT []
synonym: "Wnt receptor signalling pathway involved in mammary gland specification" EXACT [GOC:mah]
synonym: "Wnt-activated signaling pathway involved in mammary gland specification" EXACT [GOC:signaling]
is_a: GO:0016055 ! Wnt signaling pathway
intersection_of: GO:0016055 ! Wnt signaling pathway
intersection_of: part_of GO:0060594 ! mammary gland specification
relationship: part_of GO:0060594 ! mammary gland specification
created_by: dph
creation_date: 2009-05-13T09:41:37Z

[Term]
id: GO:0060594
name: mammary gland specification
namespace: biological_process
def: "The regionalization process in which the mammary line is specified. The mammary line is a ridge of epidermal cells that will form the mammary placodes." [GOC:dph]
synonym: "mammary line specification" RELATED [GOC:dph]
is_a: GO:0010092 ! specification of organ identity
is_a: GO:0060592 ! mammary gland formation
created_by: dph
creation_date: 2009-05-13T10:09:10Z

[Term]
id: GO:0060595
name: fibroblast growth factor receptor signaling pathway involved in mammary gland specification
namespace: biological_process
def: "The series of molecular signals initiated by binding of a fibroblast growth factor to its receptor on the surface of al cell in the epidermis resulting in the formation of the mammary line. The mammary line is a ridge of epidermal cells that will form the mammary placodes." [GOC:dph, PMID:16168142]
synonym: "fibroblast growth factor receptor signalling pathway involved in mammary gland specification" EXACT [GOC:mah]
is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway
intersection_of: GO:0008543 ! fibroblast growth factor receptor signaling pathway
intersection_of: part_of GO:0060594 ! mammary gland specification
relationship: part_of GO:0060594 ! mammary gland specification
created_by: dph
creation_date: 2009-05-13T10:38:18Z

[Term]
id: GO:0060596
name: mammary placode formation
namespace: biological_process
def: "The developmental process in which the mammary placode forms. The mammary placode is a transient lens shaped structure that will give rise to the mammary bud proper." [GOC:dph, PMID:16168142]
is_a: GO:0060788 ! ectodermal placode formation
relationship: part_of GO:0060592 ! mammary gland formation
created_by: dph
creation_date: 2009-05-13T11:55:20Z

[Term]
id: GO:0060597
name: regulation of transcription from RNA polymerase II promoter involved in mammary gland formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the formation of the mammary line, placode or bud." [GOC:dph, PMID:16168142]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
intersection_of: part_of GO:0060592 ! mammary gland formation
relationship: part_of GO:0060592 ! mammary gland formation
created_by: dph
creation_date: 2009-05-13T12:04:53Z

[Term]
id: GO:0060598
name: dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis
namespace: biological_process
def: "The process in which the terminal end of a mammary duct bifurcates." [GOC:dph, PMID:17120154]
synonym: "primary mammary duct branching" EXACT [GOC:dph]
is_a: GO:0060600 ! dichotomous subdivision of an epithelial terminal unit
intersection_of: GO:0060600 ! dichotomous subdivision of an epithelial terminal unit
intersection_of: part_of GO:0060751 ! branch elongation involved in mammary gland duct branching
relationship: part_of GO:0060444 ! branching involved in mammary gland duct morphogenesis
relationship: part_of GO:0060751 ! branch elongation involved in mammary gland duct branching
created_by: dph
creation_date: 2009-05-13T12:16:29Z

[Term]
id: GO:0060599
name: lateral sprouting involved in mammary gland duct morphogenesis
namespace: biological_process
def: "The process in which a branch forms along the side of a mammary duct." [GOC:dph, PMID:17120154]
synonym: "mammary gland duct secondary branching" EXACT [GOC:dph]
is_a: GO:0060601 ! lateral sprouting from an epithelium
intersection_of: GO:0060601 ! lateral sprouting from an epithelium
intersection_of: part_of GO:0060444 ! branching involved in mammary gland duct morphogenesis
relationship: part_of GO:0060444 ! branching involved in mammary gland duct morphogenesis
created_by: dph
creation_date: 2009-05-13T12:38:06Z

[Term]
id: GO:0060600
name: dichotomous subdivision of an epithelial terminal unit
namespace: biological_process
def: "The process in which an epithelial cord, rod or tube bifurcates at its end." [GOC:dph]
synonym: "primary branching of an epithelium" RELATED [GOC:dph]
is_a: GO:0002009 ! morphogenesis of an epithelium
relationship: part_of GO:0061138 ! morphogenesis of a branching epithelium
created_by: dph
creation_date: 2009-05-14T02:14:50Z

[Term]
id: GO:0060601
name: lateral sprouting from an epithelium
namespace: biological_process
def: "The process in which a branch forms along the side of an epithelium." [GOC:dph]
is_a: GO:0002009 ! morphogenesis of an epithelium
relationship: part_of GO:0061138 ! morphogenesis of a branching epithelium
created_by: dph
creation_date: 2009-05-14T02:33:01Z

[Term]
id: GO:0060602
name: branch elongation of an epithelium
namespace: biological_process
def: "The growth process in which a branch increases in length from its base to its tip." [GOC:dph]
is_a: GO:0003401 ! axis elongation
relationship: part_of GO:0061138 ! morphogenesis of a branching epithelium
created_by: dph
creation_date: 2009-05-14T02:45:44Z

[Term]
id: GO:0060603
name: mammary gland duct morphogenesis
namespace: biological_process
def: "The process in which anatomical structures of the mammary ducts are generated and organized. Mammary ducts are epithelial tubes that transport milk." [GOC:dph, PMID:17120154]
is_a: GO:0060562 ! epithelial tube morphogenesis
relationship: part_of GO:0060443 ! mammary gland morphogenesis
relationship: part_of GO:0061180 ! mammary gland epithelium development
created_by: dph
creation_date: 2009-05-15T09:22:25Z

[Term]
id: GO:0060604
name: mammary gland duct cavitation
namespace: biological_process
def: "Creation of the central hole of the mammary gland duct by the hollowing out of a solid rod." [GOC:dph, PMID:17120154]
synonym: "milk duct cavitation" RELATED [GOC:dph]
is_a: GO:0060605 ! tube lumen cavitation
relationship: part_of GO:0060603 ! mammary gland duct morphogenesis
created_by: dph
creation_date: 2009-05-15T09:34:07Z

[Term]
id: GO:0060605
name: tube lumen cavitation
namespace: biological_process
def: "The formation of a lumen by hollowing out a solid rod or cord." [GOC:dph]
is_a: GO:0035148 ! tube formation
created_by: dph
creation_date: 2009-05-15T09:39:49Z

[Term]
id: GO:0060606
name: tube closure
namespace: biological_process
def: "Creation of the central hole of a tube in an anatomical structure by sealing the edges of an epithelial fold." [GOC:dph]
is_a: GO:0035148 ! tube formation
created_by: dph
creation_date: 2009-05-15T09:44:07Z

[Term]
id: GO:0060607
name: cell-cell adhesion involved in sealing an epithelial fold
namespace: biological_process
def: "The attachment of one cell to another cell along the edges of two epithelial folds, giving rise to the lumen of an epithelial tube." [GOC:dph]
is_a: GO:0016337 ! single organismal cell-cell adhesion
relationship: part_of GO:0060606 ! tube closure
created_by: dph
creation_date: 2009-05-15T09:48:49Z

[Term]
id: GO:0060608
name: cell-cell adhesion involved in neural tube closure
namespace: biological_process
def: "The attachment of one cell to another cell along the edges of two epithelial folds, giving rise to the lumen of the neural tube." [GOC:dph]
is_a: GO:0060607 ! cell-cell adhesion involved in sealing an epithelial fold
is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules
intersection_of: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules
intersection_of: part_of GO:0001843 ! neural tube closure
relationship: part_of GO:0001843 ! neural tube closure
created_by: dph
creation_date: 2009-05-15T09:56:14Z

[Term]
id: GO:0060609
name: apoptotic process involved in tube lumen cavitation
namespace: biological_process
def: "Any apoptotic process that contributes to the hollowing out of an epithelial rod or cord to form the central hole in a tube." [GOC:dph, GOC:mtg_apoptosis]
synonym: "apoptosis involved in tube lumen cavitation" NARROW []
is_a: GO:0060561 ! apoptotic process involved in morphogenesis
intersection_of: GO:0006915 ! apoptotic process
intersection_of: part_of GO:0060605 ! tube lumen cavitation
relationship: part_of GO:0060605 ! tube lumen cavitation
created_by: dph
creation_date: 2009-05-15T10:05:39Z

[Term]
id: GO:0060610
name: mesenchymal cell differentiation involved in mammary gland development
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a mammary gland mesenchymal cell. Mammary gland mesenchymal cells form a loosely connected network of cells that surround the mammary ducts." [GOC:dph]
synonym: "mammary gland mesenchymal cell differentiation" EXACT [GOC:dph]
is_a: GO:0048762 ! mesenchymal cell differentiation
intersection_of: GO:0048762 ! mesenchymal cell differentiation
intersection_of: part_of GO:0030879 ! mammary gland development
relationship: part_of GO:0030879 ! mammary gland development
created_by: dph
creation_date: 2009-05-15T12:17:06Z

[Term]
id: GO:0060611
name: mammary gland fat development
namespace: biological_process
def: "The progression of the mammary gland fat over time, from its formation to the mature structure. The mammary fat is an adipose structure in the gland that is invaded by the mammary ducts." [GOC:dph]
is_a: GO:0060612 ! adipose tissue development
relationship: part_of GO:0030879 ! mammary gland development
created_by: dph
creation_date: 2009-05-15T12:27:57Z

[Term]
id: GO:0060612
name: adipose tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat." [GOC:dph]
synonym: "adipogenesis" RELATED [GOC:mah, GOC:sl]
is_a: GO:0061448 ! connective tissue development
relationship: part_of GO:0048513 ! animal organ development
created_by: dph
creation_date: 2009-05-15T12:36:28Z

[Term]
id: GO:0060613
name: fat pad development
namespace: biological_process
def: "The progression of a fat pad from its initial formation to its mature structure. A fat pad is an accumulation of adipose tissue." [GOC:dph]
is_a: GO:0060612 ! adipose tissue development
created_by: dph
creation_date: 2009-05-15T12:42:08Z

[Term]
id: GO:0060614
name: negative regulation of mammary gland development in males by androgen receptor signaling pathway
namespace: biological_process
def: "Any process that decreases the rate or extent of mammary gland development in the male by an androgen binding to its receptor, causing a change in state or activity of a cell." [GOC:dph]
synonym: "negative regulation of mammary gland development in males by androgen receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0030521 ! androgen receptor signaling pathway
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000026 ! regulation of multicellular organismal development
relationship: negatively_regulates GO:0030879 ! mammary gland development
created_by: dph
creation_date: 2009-05-18T08:34:40Z

[Term]
id: GO:0060615
name: mammary gland bud formation
namespace: biological_process
def: "The morphogenetic process in which a bud forms from the mammary placode. A mammary bud is bulb of epithelial cells that is distinct from the surrounding epidermis." [GOC:dph, PMID:12558599]
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0060648 ! mammary gland bud morphogenesis
created_by: dph
creation_date: 2009-05-18T08:43:14Z

[Term]
id: GO:0060616
name: mammary gland cord formation
namespace: biological_process
def: "The process in which the mammary gland cord forms by elongation of the mammary bud. The cord is formed once the elongating bud breaks through the mesenchyme and reaches the fat pad." [GOC:dph, PMID:12558599]
synonym: "mammary gland sprout formation" EXACT [GOC:dph]
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
is_a: GO:0072175 ! epithelial tube formation
relationship: part_of GO:0060652 ! mammary gland cord morphogenesis
created_by: dph
creation_date: 2009-05-18T08:57:58Z

[Term]
id: GO:0060617
name: positive regulation of mammary placode formation by mesenchymal-epithelial signaling
namespace: biological_process
def: "Any process that initiates the formation of a mammary placode through a mechanism that mediates the transfer of information from a mesenchymal cell to an epithelial cell resulting in the epithelial cell adopting the identity of a cell of the mammary placode." [GOC:dph, PMID:12558599]
synonym: "positive regulation of mammary placode formation by mesenchymal-epithelial signalling" EXACT [GOC:mah]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0060638 ! mesenchymal-epithelial cell signaling
is_a: GO:2000027 ! regulation of organ morphogenesis
relationship: positively_regulates GO:0060596 ! mammary placode formation
created_by: dph
creation_date: 2009-05-18T09:16:07Z

[Term]
id: GO:0060618
name: nipple development
namespace: biological_process
def: "The progression of the nipple over time, from its formation to the mature structure. The nipple is a part of the mammary gland that protrudes from the surface ectoderm." [GOC:dph]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0030879 ! mammary gland development
created_by: dph
creation_date: 2009-05-18T09:29:38Z

[Term]
id: GO:0060619
name: cell migration involved in mammary placode formation
namespace: biological_process
def: "The orderly movement of epithelial cells within the mammary line that contributes to the formation of the mammary placode." [GOC:dph, PMID:12558599]
is_a: GO:0010631 ! epithelial cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: part_of GO:0060596 ! mammary placode formation
relationship: part_of GO:0060596 ! mammary placode formation
created_by: dph
creation_date: 2009-05-18T09:41:49Z

[Term]
id: GO:0060620
name: regulation of cholesterol import
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of cholesterol import. Cholesterol import is the directed movement of cholesterol into a cell or organelle." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0032374 ! regulation of cholesterol transport
is_a: GO:2000909 ! regulation of sterol import
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070508 ! cholesterol import
relationship: regulates GO:0070508 ! cholesterol import
created_by: dph
creation_date: 2009-05-18T01:41:08Z

[Term]
id: GO:0060621
name: negative regulation of cholesterol import
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of cholesterol import. Cholesterol import is the directed movement of cholesterol into a cell or organelle." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0032375 ! negative regulation of cholesterol transport
is_a: GO:0060620 ! regulation of cholesterol import
is_a: GO:2000910 ! negative regulation of sterol import
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070508 ! cholesterol import
relationship: negatively_regulates GO:0070508 ! cholesterol import
created_by: dph
creation_date: 2009-05-18T01:46:21Z

[Term]
id: GO:0060622
name: regulation of ascospore wall beta-glucan biosynthetic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of ascospore wall beta-glucan biosynthetic process, the chemical reactions and pathways resulting in the formation of beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of ascospores." [GOC:dph, GOC:tb]
is_a: GO:0034307 ! regulation of ascospore formation
is_a: GO:0090093 ! regulation of fungal-type cell wall beta-glucan biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034412 ! ascospore wall beta-glucan biosynthetic process
relationship: regulates GO:0034412 ! ascospore wall beta-glucan biosynthetic process
created_by: dph
creation_date: 2009-05-18T02:01:26Z

[Term]
id: GO:0060623
name: regulation of chromosome condensation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of chromosome condensation, the progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." [GOC:dph, GOC:tb]
is_a: GO:0033044 ! regulation of chromosome organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030261 ! chromosome condensation
relationship: regulates GO:0030261 ! chromosome condensation
created_by: dph
creation_date: 2009-05-18T02:12:13Z

[Term]
id: GO:0060624
name: regulation of ascospore wall (1->3)-beta-D-glucan biosynthetic process
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of ascospore wall (1->3)-beta-D-glucan biosynthetic process, the chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D--glucosidic bonds, found in the walls of ascospores." [GOC:dph, GOC:tb]
synonym: "regulation of ascospore wall 1,3-beta-D-glucan biosynthetic process" BROAD []
synonym: "regulation of ascospore wall 1,3-beta-glucan biosynthetic process" BROAD []
is_a: GO:0060622 ! regulation of ascospore wall beta-glucan biosynthetic process
is_a: GO:0090334 ! regulation of cell wall (1->3)-beta-D-glucan biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034413 ! ascospore wall (1->3)-beta-D-glucan biosynthetic process
relationship: regulates GO:0034413 ! ascospore wall (1->3)-beta-D-glucan biosynthetic process
created_by: dph
creation_date: 2009-05-18T02:18:10Z

[Term]
id: GO:0060625
name: regulation of protein deneddylation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of protein deneddylation, the removal of a ubiquitin-like protein of the NEDD8 type from a protein." [GOC:dph, GOC:tb]
is_a: GO:0030162 ! regulation of proteolysis
is_a: GO:1903320 ! regulation of protein modification by small protein conjugation or removal
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000338 ! protein deneddylation
relationship: regulates GO:0000338 ! protein deneddylation
created_by: dph
creation_date: 2009-05-18T02:22:07Z

[Term]
id: GO:0060626
name: regulation of cullin deneddylation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of cullin deneddylation, the modification of cullins by removal of ubiquitin-like protein NEDD8 (RUB1)." [GOC:dph, GOC:tb]
is_a: GO:0060625 ! regulation of protein deneddylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010388 ! cullin deneddylation
relationship: regulates GO:0010388 ! cullin deneddylation
created_by: dph
creation_date: 2009-05-18T02:25:48Z

[Term]
id: GO:0060627
name: regulation of vesicle-mediated transport
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell." [GOC:dph, GOC:tb]
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016192 ! vesicle-mediated transport
relationship: regulates GO:0016192 ! vesicle-mediated transport
created_by: dph
creation_date: 2009-05-18T02:29:43Z

[Term]
id: GO:0060628
name: regulation of ER to Golgi vesicle-mediated transport
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of ER to Golgi vesicle-mediated transport, the directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:dph, GOC:tb]
is_a: GO:0060627 ! regulation of vesicle-mediated transport
is_a: GO:1903649 ! regulation of cytoplasmic transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006888 ! ER to Golgi vesicle-mediated transport
relationship: regulates GO:0006888 ! ER to Golgi vesicle-mediated transport
created_by: dph
creation_date: 2009-05-18T02:37:00Z

[Term]
id: GO:0060629
name: regulation of homologous chromosome segregation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of homologous chromosome segregation, the cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the first division of the meiotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner; this pairing off, referred to as synapsis, permits genetic recombination. One homolog (both sister chromatids) of each morphologic type goes into each of the resulting chromosome sets." [GOC:dph, GOC:tb]
is_a: GO:0051983 ! regulation of chromosome segregation
is_a: GO:0060631 ! regulation of meiosis I
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045143 ! homologous chromosome segregation
relationship: regulates GO:0045143 ! homologous chromosome segregation
created_by: dph
creation_date: 2009-05-18T02:41:02Z

[Term]
id: GO:0060630
name: obsolete regulation of M/G1 transition of mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that modulates the rate, frequency, or extent of M/G1 transition of the mitotic cell cycle, the progression from M phase to G1 phase of the mitotic cell cycle." [GOC:dph, GOC:mtg_cell_cycle, GOC:tb]
comment: This term was made obsolete because it does not refer to a real biological process.
synonym: "regulation of M/G1 transition of mitotic cell cycle" EXACT []
is_obsolete: true
created_by: dph
creation_date: 2009-05-18T02:48:58Z

[Term]
id: GO:0060631
name: regulation of meiosis I
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of meiosis I, a cell cycle process comprising the steps by which a cell progresses through the first phase of meiosis, in which cells divide and homologous chromosomes are paired and segregated from each other, producing two daughter cells." [GOC:dph, GOC:tb]
is_a: GO:0040020 ! regulation of meiotic nuclear division
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007127 ! meiosis I
relationship: regulates GO:0007127 ! meiosis I
created_by: dph
creation_date: 2009-05-18T02:55:19Z

[Term]
id: GO:0060632
name: regulation of microtubule-based movement
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of microtubule-based movement, the movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins." [GOC:dph, GOC:tb]
is_a: GO:0032886 ! regulation of microtubule-based process
is_a: GO:0051270 ! regulation of cellular component movement
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007018 ! microtubule-based movement
relationship: regulates GO:0007018 ! microtubule-based movement
created_by: dph
creation_date: 2009-05-18T03:07:02Z

[Term]
id: GO:0060633
name: negative regulation of transcription initiation from RNA polymerase II promoter
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter." [GOC:dph, GOC:tb, GOC:txnOH]
is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
is_a: GO:0060260 ! regulation of transcription initiation from RNA polymerase II promoter
is_a: GO:2000143 ! negative regulation of DNA-templated transcription, initiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006367 ! transcription initiation from RNA polymerase II promoter
relationship: negatively_regulates GO:0006367 ! transcription initiation from RNA polymerase II promoter
created_by: dph
creation_date: 2009-05-18T03:11:26Z

[Term]
id: GO:0060634
name: regulation of 4,6-pyruvylated galactose residue biosynthetic process
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of 4,6-pyruvylated galactose residue biosynthetic process, the chemical reactions and pathways resulting in the formation of the pyruvylated galactose residue 4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-(1->3)-. The galactose residue is part of a larger polysaccharide chain." [GOC:dph, GOC:tb]
is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process
is_a: GO:0032885 ! regulation of polysaccharide biosynthetic process
is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051072 ! 4,6-pyruvylated galactose residue biosynthetic process
relationship: regulates GO:0051072 ! 4,6-pyruvylated galactose residue biosynthetic process
created_by: dph
creation_date: 2009-05-18T03:15:39Z

[Term]
id: GO:0060635
name: positive regulation of (1->3)-beta-D-glucan biosynthetic process
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans." [GOC:dph, GOC:tb]
synonym: "positive regulation of 1,3-beta-D-glucan biosynthetic process" EXACT []
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0032953 ! regulation of (1->3)-beta-D-glucan biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006075 ! (1->3)-beta-D-glucan biosynthetic process
relationship: positively_regulates GO:0006075 ! (1->3)-beta-D-glucan biosynthetic process
created_by: dph
creation_date: 2009-05-18T03:22:44Z

[Term]
id: GO:0060636
name: negative regulation of (1->3)-beta-D-glucan biosynthetic process
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans." [GOC:dph, GOC:tb]
synonym: "negative regulation of 1,3-beta-D-glucan biosynthetic process" EXACT []
is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process
is_a: GO:0032953 ! regulation of (1->3)-beta-D-glucan biosynthetic process
is_a: GO:2000113 ! negative regulation of cellular macromolecule biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006075 ! (1->3)-beta-D-glucan biosynthetic process
relationship: negatively_regulates GO:0006075 ! (1->3)-beta-D-glucan biosynthetic process
created_by: dph
creation_date: 2009-05-18T03:24:02Z

[Term]
id: GO:0060637
name: positive regulation of lactation by mesenchymal-epithelial cell signaling
namespace: biological_process
def: "The process that increases the rate, frequency, or extent of lactation as a result of the secretion of a signal from the mammary fat and its reception by a mammary epithelial cell." [GOC:dph, PMID:12558599]
synonym: "positive regulation of lactation by mesenchymal-epithelial cell signalling" EXACT [GOC:mah]
is_a: GO:0060638 ! mesenchymal-epithelial cell signaling
is_a: GO:1903489 ! positive regulation of lactation
relationship: positively_regulates GO:0007595 ! lactation
created_by: dph
creation_date: 2009-05-19T03:39:24Z

[Term]
id: GO:0060638
name: mesenchymal-epithelial cell signaling
namespace: biological_process
def: "Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell where it is received and interpreted." [GOC:dph]
synonym: "mesenchymal-epithelial cell signalling" EXACT [GOC:mah]
is_a: GO:0007267 ! cell-cell signaling
created_by: dph
creation_date: 2009-05-19T03:59:05Z

[Term]
id: GO:0060639
name: positive regulation of salivary gland formation by mesenchymal-epithelial signaling
namespace: biological_process
def: "Any process that induces the formation of the salivary gland field by means of the secretion of a signal by a mesenchymal cell and its reception and interpretation by an epithelial cell resulting in it adopting the identity of a salivary gland bud cell." [GOC:dph]
synonym: "positive regulation of salivary gland formation by mesenchymal-epithelial signalling" EXACT [GOC:mah]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0060638 ! mesenchymal-epithelial cell signaling
is_a: GO:2000027 ! regulation of organ morphogenesis
relationship: positively_regulates GO:0007435 ! salivary gland morphogenesis
created_by: dph
creation_date: 2009-05-20T04:26:43Z

[Term]
id: GO:0060640
name: positive regulation of dentin-containing tooth bud formation by mesenchymal-epithelial signaling
namespace: biological_process
def: "Any process that initiates the formation of a tooth bud by the secretion of a signal from a mesenchymal cell and its reception and subsequent change in the identity of an epithelial cell of the tooth bud." [GOC:dph]
synonym: "positive regulation of dentine-containing tooth bud formation by mesenchymal-epithelial signaling" RELATED []
synonym: "positive regulation of dentine-containing tooth bud formation by mesenchymal-epithelial signalling" EXACT [GOC:mah]
is_a: GO:0042488 ! positive regulation of odontogenesis of dentin-containing tooth
is_a: GO:0060638 ! mesenchymal-epithelial cell signaling
created_by: dph
creation_date: 2009-05-20T04:33:52Z

[Term]
id: GO:0060641
name: mammary gland duct regression in males
namespace: biological_process
def: "The process in which the epithelium of the mammary duct is destroyed in males." [GOC:dph, PMID:12558599]
is_a: GO:0060033 ! anatomical structure regression
relationship: part_of GO:0060603 ! mammary gland duct morphogenesis
created_by: dph
creation_date: 2009-05-20T04:50:57Z

[Term]
id: GO:0060642
name: white fat cell differentiation involved in mammary gland fat development
namespace: biological_process
def: "The process in which a preadipocyte acquires specialized features of a white adipocyte of the mammary gland. White adipocytes have cytoplasmic lipids arranged in a unique vacuole." [GOC:dph, PMID:12558599]
is_a: GO:0050872 ! white fat cell differentiation
intersection_of: GO:0050872 ! white fat cell differentiation
intersection_of: part_of GO:0060611 ! mammary gland fat development
relationship: part_of GO:0060611 ! mammary gland fat development
created_by: dph
creation_date: 2009-05-27T05:50:56Z

[Term]
id: GO:0060643
name: epithelial cell differentiation involved in mammary gland bud morphogenesis
namespace: biological_process
def: "The process in which a cell of the mammary placode becomes a cell of the mammary gland bud." [GOC:dph]
is_a: GO:0060644 ! mammary gland epithelial cell differentiation
intersection_of: GO:0030855 ! epithelial cell differentiation
intersection_of: part_of GO:0060648 ! mammary gland bud morphogenesis
relationship: part_of GO:0060615 ! mammary gland bud formation
relationship: part_of GO:0060648 ! mammary gland bud morphogenesis
created_by: dph
creation_date: 2009-05-29T07:58:13Z

[Term]
id: GO:0060644
name: mammary gland epithelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland." [GOC:dph]
is_a: GO:0030855 ! epithelial cell differentiation
relationship: part_of GO:0061180 ! mammary gland epithelium development
created_by: dph
creation_date: 2009-05-29T08:03:07Z

[Term]
id: GO:0060645
name: peripheral mammary gland bud epithelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized epithelial cell of the mammary placode becomes an epithelial cell at the periphery of the mammary gland bud. Cells at the periphery of the bud are larger that those of the surrounding epithelium and are arranged concentrically." [GOC:dph, PMID:12558599]
is_a: GO:0060643 ! epithelial cell differentiation involved in mammary gland bud morphogenesis
created_by: dph
creation_date: 2009-05-29T08:06:16Z

[Term]
id: GO:0060646
name: internal mammary gland bud epithelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized epithelial cell of the mammary placode becomes an internal epithelial cell of the mammary gland bud. Internal cells are small and of irregular shape." [GOC:dph, PMID:12558599]
is_a: GO:0060643 ! epithelial cell differentiation involved in mammary gland bud morphogenesis
created_by: dph
creation_date: 2009-05-29T08:10:48Z

[Term]
id: GO:0060647
name: mesenchymal cell condensation involved in mammary fat development
namespace: biological_process
def: "The cell adhesion process in which mammary mesenchyme cells adhere to one another in the initial stages of the formation of mammary fat development." [GOC:dph, PMID:12558599]
is_a: GO:0016337 ! single organismal cell-cell adhesion
intersection_of: GO:0016337 ! single organismal cell-cell adhesion
intersection_of: part_of GO:0060611 ! mammary gland fat development
relationship: part_of GO:0060611 ! mammary gland fat development
created_by: dph
creation_date: 2009-05-29T08:33:29Z

[Term]
id: GO:0060648
name: mammary gland bud morphogenesis
namespace: biological_process
def: "The process in which anatomical structures of the mammary gland buds are generated and organized. Mammary gland buds form by an outpocketing of the mammary placodes and grow to invade the mammary fat, when they form the mammary cord." [GOC:dph, PMID:12558599]
is_a: GO:0060572 ! morphogenesis of an epithelial bud
relationship: part_of GO:0060603 ! mammary gland duct morphogenesis
created_by: dph
creation_date: 2009-05-29T08:42:22Z

[Term]
id: GO:0060649
name: mammary gland bud elongation
namespace: biological_process
def: "The process in which the mammary gland bud grows along its axis." [GOC:dph, PMID:12558599]
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0060648 ! mammary gland bud morphogenesis
created_by: dph
creation_date: 2009-05-29T08:50:39Z

[Term]
id: GO:0060650
name: epithelial cell proliferation involved in mammary gland bud elongation
namespace: biological_process
def: "The multiplication or reproduction of mammary gland bud epithelial cells, resulting in the elongation of the bud." [GOC:dph, PMID:12558599]
is_a: GO:0033598 ! mammary gland epithelial cell proliferation
intersection_of: GO:0050673 ! epithelial cell proliferation
intersection_of: part_of GO:0060649 ! mammary gland bud elongation
relationship: part_of GO:0060649 ! mammary gland bud elongation
created_by: dph
creation_date: 2009-05-29T08:54:54Z

[Term]
id: GO:0060651
name: regulation of epithelial cell proliferation involved in mammary gland bud elongation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mammary gland bud epithelial cell proliferation that results in the elongation of the bud." [GOC:dph, PMID:12558599]
is_a: GO:0033599 ! regulation of mammary gland epithelial cell proliferation
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:2000027 ! regulation of organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060650 ! epithelial cell proliferation involved in mammary gland bud elongation
relationship: regulates GO:0060650 ! epithelial cell proliferation involved in mammary gland bud elongation
created_by: dph
creation_date: 2009-05-29T08:57:18Z

[Term]
id: GO:0060652
name: mammary gland cord morphogenesis
namespace: biological_process
def: "The process in which anatomical structures of the mammary gland cord are generated and organized. Mammary gland cords form when the mammary gland bud invades the mammary fat." [GOC:dph, PMID:12558599]
synonym: "mammary gland sprout morphogenesis" EXACT [GOC:dph]
is_a: GO:0060562 ! epithelial tube morphogenesis
relationship: part_of GO:0060603 ! mammary gland duct morphogenesis
created_by: dph
creation_date: 2009-05-29T09:06:56Z

[Term]
id: GO:0060653
name: epithelial cell differentiation involved in mammary gland cord morphogenesis
namespace: biological_process
def: "The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland cord. Epithelial cells of the mammary cord give it its funnel-like shape and some are cornified." [GOC:dph, PMID:12558599]
synonym: "epithelial cell differentiation involved in mammary gland sprout morphogenesis" RELATED [GOC:dph]
is_a: GO:0060644 ! mammary gland epithelial cell differentiation
intersection_of: GO:0030855 ! epithelial cell differentiation
intersection_of: part_of GO:0060652 ! mammary gland cord morphogenesis
relationship: part_of GO:0060652 ! mammary gland cord morphogenesis
created_by: dph
creation_date: 2009-05-29T09:17:16Z

[Term]
id: GO:0060654
name: mammary gland cord elongation
namespace: biological_process
def: "The process in which the mammary gland sprout grows along its axis." [GOC:dph, PMID:12558599]
is_a: GO:0060751 ! branch elongation involved in mammary gland duct branching
relationship: part_of GO:0060652 ! mammary gland cord morphogenesis
created_by: dph
creation_date: 2009-05-29T09:26:15Z

[Term]
id: GO:0060655
name: branching involved in mammary gland cord morphogenesis
namespace: biological_process
def: "The process in which the branching structure of the mammary gland cord is generated and organized. The mammary gland cord is a solid epithelial structure that will hollow out, forming the mammary duct." [GOC:dph, PMID:12558599]
is_a: GO:0060444 ! branching involved in mammary gland duct morphogenesis
intersection_of: GO:0061138 ! morphogenesis of a branching epithelium
intersection_of: part_of GO:0060652 ! mammary gland cord morphogenesis
relationship: part_of GO:0060652 ! mammary gland cord morphogenesis
created_by: dph
creation_date: 2009-05-29T09:29:32Z

[Term]
id: GO:0060656
name: regulation of branching involved in mammary cord morphogenesis by fat precursor cell-epithelial cell signaling
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of branching of the mammary gland cord as a result of a signal being created by a mammary fat precursor cell and its subsequent reception and interpretation by a mammary cord epithelial cell." [GOC:dph, PMID:12558599]
synonym: "regulation of branching involved in mammary cord morphogenesis by fat precursor cell-epithelial cell signalling" EXACT [GOC:mah]
is_a: GO:0007267 ! cell-cell signaling
is_a: GO:0060762 ! regulation of branching involved in mammary gland duct morphogenesis
relationship: regulates GO:0060655 ! branching involved in mammary gland cord morphogenesis
created_by: dph
creation_date: 2009-05-29T09:34:31Z

[Term]
id: GO:0060657
name: regulation of mammary gland cord elongation by mammary fat precursor cell-epithelial cell signaling
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of mammary gland cord elongation as a result of a signal being created by a mesenchymal cell that is a precursor to the mammary fat and its subsequent reception and interpretation by an mammary cord epithelial cell." [GOC:dph, PMID:12558599]
synonym: "regulation of mammary gland cord elongation by mammary fat precursor cell-epithelial cell signalling" EXACT [GOC:mah]
is_a: GO:0007267 ! cell-cell signaling
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:0060762 ! regulation of branching involved in mammary gland duct morphogenesis
relationship: regulates GO:0060654 ! mammary gland cord elongation
created_by: dph
creation_date: 2009-05-29T09:43:08Z

[Term]
id: GO:0060658
name: nipple morphogenesis
namespace: biological_process
def: "The process in which the nipple is generated and organized." [GOC:dph]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0060618 ! nipple development
created_by: dph
creation_date: 2009-05-29T10:45:44Z

[Term]
id: GO:0060659
name: nipple sheath formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the nipple sheath from the unspecified epidermis. This process begins with a circular ingrowth of the epidermis around the region of the mammary sprout. It ends before the region begins to elevate." [GOC:dph, PMID:12558599]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0060658 ! nipple morphogenesis
created_by: dph
creation_date: 2009-05-29T10:48:39Z

[Term]
id: GO:0060660
name: epidermis morphogenesis involved in nipple formation
namespace: biological_process
def: "The process in which the epidermis of the nipple sheath is uplifted to form an umbrella-like projection." [GOC:dph, PMID:12558599]
is_a: GO:0048730 ! epidermis morphogenesis
intersection_of: GO:0048730 ! epidermis morphogenesis
intersection_of: part_of GO:0060658 ! nipple morphogenesis
relationship: part_of GO:0060658 ! nipple morphogenesis
created_by: dph
creation_date: 2009-05-29T11:04:04Z

[Term]
id: GO:0060661
name: submandibular salivary gland formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a submandibular salivary gland. This process begins with a thickening of the epithelium next to the tongue and ends when a bud linked to the oral surface is formed." [GOC:dph, PMID:17336109]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0007435 ! salivary gland morphogenesis
created_by: dph
creation_date: 2009-06-01T08:07:16Z

[Term]
id: GO:0060662
name: salivary gland cavitation
namespace: biological_process
def: "The process in which the solid core of salivary epithelium gives rise to the hollow tube of the gland." [GOC:dph]
is_a: GO:0060605 ! tube lumen cavitation
relationship: part_of GO:0007435 ! salivary gland morphogenesis
created_by: dph
creation_date: 2009-06-01T08:22:55Z

[Term]
id: GO:0060663
name: apoptotic process involved in salivary gland cavitation
namespace: biological_process
def: "Any apoptotic process in which the solid core of the gland is hollowed out to form the duct." [GOC:dph, GOC:mtg_apoptosis, PMID:17336109]
synonym: "apoptosis involved in salivary gland cavitation" NARROW []
is_a: GO:0060609 ! apoptotic process involved in tube lumen cavitation
intersection_of: GO:0006915 ! apoptotic process
intersection_of: part_of GO:0060662 ! salivary gland cavitation
relationship: part_of GO:0060662 ! salivary gland cavitation
created_by: dph
creation_date: 2009-06-01T08:27:16Z

[Term]
id: GO:0060664
name: epithelial cell proliferation involved in salivary gland morphogenesis
namespace: biological_process
def: "The multiplication or reproduction of epithelial cells of the submandibular salivary gland, resulting in the expansion of a cell population and the shaping of the gland." [GOC:dph, PMID:17336109]
is_a: GO:0050673 ! epithelial cell proliferation
intersection_of: GO:0050673 ! epithelial cell proliferation
intersection_of: part_of GO:0007435 ! salivary gland morphogenesis
relationship: part_of GO:0007435 ! salivary gland morphogenesis
created_by: dph
creation_date: 2009-06-01T08:36:13Z

[Term]
id: GO:0060665
name: regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of branching involved in salivary gland morphogenesis as a result of signals being generated by the mesenchyme and received and interpreted by the salivary gland epithelium." [GOC:dph, PMID:17336109]
synonym: "regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signalling" EXACT [GOC:mah]
is_a: GO:0060638 ! mesenchymal-epithelial cell signaling
is_a: GO:0060693 ! regulation of branching involved in salivary gland morphogenesis
created_by: dph
creation_date: 2009-06-01T08:42:36Z

[Term]
id: GO:0060666
name: dichotomous subdivision of terminal units involved in salivary gland branching
namespace: biological_process
def: "The process in which a salivary epithelial cord bifurcates at its end." [GOC:dph]
is_a: GO:0060600 ! dichotomous subdivision of an epithelial terminal unit
intersection_of: GO:0060600 ! dichotomous subdivision of an epithelial terminal unit
intersection_of: part_of GO:0060445 ! branching involved in salivary gland morphogenesis
relationship: part_of GO:0060445 ! branching involved in salivary gland morphogenesis
created_by: dph
creation_date: 2009-06-01T09:38:40Z

[Term]
id: GO:0060667
name: branch elongation involved in salivary gland morphogenesis
namespace: biological_process
def: "The differential growth of the salivary branches along their axis, resulting in the growth of a branch." [GOC:dph]
is_a: GO:0060602 ! branch elongation of an epithelium
intersection_of: GO:0060602 ! branch elongation of an epithelium
intersection_of: part_of GO:0007435 ! salivary gland morphogenesis
relationship: part_of GO:0007435 ! salivary gland morphogenesis
relationship: part_of GO:0060445 ! branching involved in salivary gland morphogenesis
created_by: dph
creation_date: 2009-06-01T09:42:13Z

[Term]
id: GO:0060668
name: regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of salivary gland branching as a result of the transfer of information from the extracellular matrix to the epithelium of the salivary gland." [GOC:dph]
synonym: "regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signalling" EXACT [GOC:mah]
is_a: GO:0035426 ! extracellular matrix-cell signaling
is_a: GO:0060693 ! regulation of branching involved in salivary gland morphogenesis
created_by: dph
creation_date: 2009-06-01T09:47:56Z

[Term]
id: GO:0060669
name: embryonic placenta morphogenesis
namespace: biological_process
def: "The process in which the embryonic placenta is generated and organized." [GOC:dph]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0001892 ! embryonic placenta development
created_by: dph
creation_date: 2009-06-02T09:33:37Z

[Term]
id: GO:0060670
name: branching involved in labyrinthine layer morphogenesis
namespace: biological_process
def: "The process in which the branches of the fetal placental villi are generated and organized. The villous part of the placenta is called the labyrinth layer." [GOC:dph, PMID:16916377]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0061138 ! morphogenesis of a branching epithelium
intersection_of: GO:0061138 ! morphogenesis of a branching epithelium
intersection_of: part_of GO:0060713 ! labyrinthine layer morphogenesis
relationship: part_of GO:0060713 ! labyrinthine layer morphogenesis
created_by: dph
creation_date: 2009-06-02T10:40:40Z

[Term]
id: GO:0060671
name: epithelial cell differentiation involved in embryonic placenta development
namespace: biological_process
def: "The process in which a trophoblast cell acquires specialized features of an epithelial cell of the placental labyrinthine layer." [GOC:dph, PMID:16916377]
is_a: GO:0030855 ! epithelial cell differentiation
is_a: GO:0060706 ! cell differentiation involved in embryonic placenta development
intersection_of: GO:0030855 ! epithelial cell differentiation
intersection_of: part_of GO:0001892 ! embryonic placenta development
relationship: part_of GO:0001892 ! embryonic placenta development
relationship: part_of GO:0060711 ! labyrinthine layer development
created_by: dph
creation_date: 2009-06-02T11:40:52Z

[Term]
id: GO:0060672
name: epithelial cell morphogenesis involved in placental branching
namespace: biological_process
def: "The change in form (cell shape and size) that occurs when a trophoblast cell elongates to contribute to the branching of the placenta." [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:16916377]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0003382 ! epithelial cell morphogenesis
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0060670 ! branching involved in labyrinthine layer morphogenesis
relationship: part_of GO:0060671 ! epithelial cell differentiation involved in embryonic placenta development
created_by: dph
creation_date: 2009-06-02T12:44:52Z

[Term]
id: GO:0060673
name: cell-cell signaling involved in placenta development
namespace: biological_process
def: "Any process that mediates the transfer of information from one cell to another." [GOC:dph, PMID:16916377]
synonym: "cell-cell signalling involved in placenta development" EXACT [GOC:mah]
is_a: GO:0007267 ! cell-cell signaling
is_a: GO:0044702 ! single organism reproductive process
intersection_of: GO:0007267 ! cell-cell signaling
intersection_of: part_of GO:0001890 ! placenta development
relationship: part_of GO:0001890 ! placenta development
relationship: part_of GO:0001892 ! embryonic placenta development
created_by: dph
creation_date: 2009-06-02T12:58:03Z

[Term]
id: GO:0060674
name: placenta blood vessel development
namespace: biological_process
def: "The process whose specific outcome is the progression of a blood vessel of the placenta over time, from its formation to the mature structure." [GOC:dph, PMID:16916377]
is_a: GO:0001568 ! blood vessel development
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
relationship: part_of GO:0001890 ! placenta development
created_by: dph
creation_date: 2009-06-02T01:09:43Z

[Term]
id: GO:0060675
name: ureteric bud morphogenesis
namespace: biological_process
def: "The process in which the ureteric bud is generated and organized." [GOC:dph, GOC:mtg_kidney_jan10]
is_a: GO:0072171 ! mesonephric tubule morphogenesis
relationship: part_of GO:0001657 ! ureteric bud development
created_by: dph
creation_date: 2009-06-02T01:31:41Z

[Term]
id: GO:0060676
name: ureteric bud formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the ureteric bud from the Wolffian duct. This process begins when the bud protrudes from the duct and ends when it is a recognizable bud." [GOC:dph, PMID:16916378]
is_a: GO:0072172 ! mesonephric tubule formation
relationship: part_of GO:0060675 ! ureteric bud morphogenesis
created_by: dph
creation_date: 2009-06-02T01:47:23Z

[Term]
id: GO:0060677
name: ureteric bud elongation
namespace: biological_process
def: "The developmental growth in which the ureteric bud grows along its axis beginning with the growth of the primary ureteric bud and ending when the branches of the bud have elongated." [GOC:dph, PMID:16916378]
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0060675 ! ureteric bud morphogenesis
created_by: dph
creation_date: 2009-06-02T02:13:29Z

[Term]
id: GO:0060678
name: dichotomous subdivision of terminal units involved in ureteric bud branching
namespace: biological_process
def: "The process in which a ureteric bud bifurcates at its end." [GOC:dph, PMID:16916378]
synonym: "bifid subdivision of terminal units involved in ureteric bud branching" EXACT [GOC:dph, PMID:16916378]
is_a: GO:0060600 ! dichotomous subdivision of an epithelial terminal unit
intersection_of: GO:0060600 ! dichotomous subdivision of an epithelial terminal unit
intersection_of: part_of GO:0001658 ! branching involved in ureteric bud morphogenesis
relationship: part_of GO:0001658 ! branching involved in ureteric bud morphogenesis
created_by: dph
creation_date: 2009-06-02T02:18:17Z

[Term]
id: GO:0060679
name: trifid subdivision of terminal units involved in ureteric bud branching
namespace: biological_process
def: "The process in which a ureteric bud splits into three units at its end." [GOC:dph, PMID:16916378]
is_a: GO:0002009 ! morphogenesis of an epithelium
relationship: part_of GO:0001658 ! branching involved in ureteric bud morphogenesis
created_by: dph
creation_date: 2009-06-02T02:37:42Z

[Term]
id: GO:0060680
name: lateral sprouting involved in ureteric bud morphogenesis
namespace: biological_process
def: "The process in which a branch forms along the side of a ureteric bud." [GOC:dph, PMID:16916378]
is_a: GO:0060601 ! lateral sprouting from an epithelium
intersection_of: GO:0060601 ! lateral sprouting from an epithelium
intersection_of: part_of GO:0001658 ! branching involved in ureteric bud morphogenesis
relationship: part_of GO:0001658 ! branching involved in ureteric bud morphogenesis
created_by: dph
creation_date: 2009-06-02T02:44:27Z

[Term]
id: GO:0060681
name: branch elongation involved in ureteric bud branching
namespace: biological_process
def: "The growth of a branch of the ureteric bud along its axis." [GOC:dph, PMID:16916378]
is_a: GO:0060602 ! branch elongation of an epithelium
intersection_of: GO:0060602 ! branch elongation of an epithelium
intersection_of: part_of GO:0001658 ! branching involved in ureteric bud morphogenesis
relationship: part_of GO:0001658 ! branching involved in ureteric bud morphogenesis
relationship: part_of GO:0060677 ! ureteric bud elongation
created_by: dph
creation_date: 2009-06-02T02:52:55Z

[Term]
id: GO:0060682
name: primary ureteric bud growth
namespace: biological_process
def: "The process in which the primary ureteric bud grows along its axis dorsally toward the metanephric blastema." [GOC:dph, PMID:16916378]
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0060677 ! ureteric bud elongation
created_by: dph
creation_date: 2009-06-02T02:56:01Z

[Term]
id: GO:0060683
name: regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of salivary gland branching as a result of the transfer of information from the epithelial cells to the mesenchymal cells of the salivary gland." [GOC:dph, PMID:18559345]
synonym: "regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signalling" EXACT [GOC:mah]
is_a: GO:0060684 ! epithelial-mesenchymal cell signaling
is_a: GO:0060693 ! regulation of branching involved in salivary gland morphogenesis
created_by: dph
creation_date: 2009-06-03T06:30:56Z

[Term]
id: GO:0060684
name: epithelial-mesenchymal cell signaling
namespace: biological_process
def: "Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell where it is interpreted." [GOC:dph]
synonym: "epithelial-mesenchymal cell signalling" EXACT [GOC:mah]
is_a: GO:0007267 ! cell-cell signaling
created_by: dph
creation_date: 2009-06-03T06:36:46Z

[Term]
id: GO:0060685
name: regulation of prostatic bud formation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of prostatic bud formation, the morphogenetic process in which a region of the fetal urogenital sinus epithelium is specified to become the prostate, resulting in prostate bud outgrowth." [GOC:dph]
is_a: GO:0003156 ! regulation of organ formation
is_a: GO:0045995 ! regulation of embryonic development
is_a: GO:0060688 ! regulation of morphogenesis of a branching structure
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060513 ! prostatic bud formation
relationship: regulates GO:0060513 ! prostatic bud formation
created_by: dph
creation_date: 2009-06-05T12:29:26Z

[Term]
id: GO:0060686
name: negative regulation of prostatic bud formation
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of prostatic bud formation, the morphogenetic process in which a region of the fetal urogenital sinus epithelium is specified to become the prostate, resulting in prostate bud outgrowth." [GOC:dph]
is_a: GO:0045992 ! negative regulation of embryonic development
is_a: GO:0060685 ! regulation of prostatic bud formation
is_a: GO:2000242 ! negative regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060513 ! prostatic bud formation
relationship: negatively_regulates GO:0060513 ! prostatic bud formation
created_by: dph
creation_date: 2009-06-05T12:35:25Z

[Term]
id: GO:0060687
name: regulation of branching involved in prostate gland morphogenesis
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of prostate gland branching, the process in which the branching structure of the prostate gland is generated and organized. A branch is a division or offshoot from a main stem." [GOC:dph]
is_a: GO:0060688 ! regulation of morphogenesis of a branching structure
is_a: GO:2000027 ! regulation of organ morphogenesis
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060442 ! branching involved in prostate gland morphogenesis
relationship: regulates GO:0060442 ! branching involved in prostate gland morphogenesis
created_by: dph
creation_date: 2009-06-05T12:37:14Z

[Term]
id: GO:0060688
name: regulation of morphogenesis of a branching structure
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of branching morphogenesis, the process in which the anatomical structures of branches are generated and organized." [GOC:dph]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001763 ! morphogenesis of a branching structure
relationship: regulates GO:0001763 ! morphogenesis of a branching structure
created_by: dph
creation_date: 2009-06-05T12:41:44Z

[Term]
id: GO:0060689
name: cell differentiation involved in salivary gland development
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features that characterize the cells of the salivary gland." [GOC:dph]
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: part_of GO:0007431 ! salivary gland development
relationship: part_of GO:0007431 ! salivary gland development
created_by: dph
creation_date: 2009-06-08T01:01:35Z

[Term]
id: GO:0060690
name: epithelial cell differentiation involved in salivary gland development
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquire specialized structural and/or functional features of an epithelial cell of the salivary gland." [GOC:dph]
is_a: GO:0030855 ! epithelial cell differentiation
is_a: GO:0060689 ! cell differentiation involved in salivary gland development
intersection_of: GO:0030855 ! epithelial cell differentiation
intersection_of: part_of GO:0007431 ! salivary gland development
relationship: part_of GO:0007431 ! salivary gland development
created_by: dph
creation_date: 2009-06-08T01:04:19Z

[Term]
id: GO:0060691
name: epithelial cell maturation involved in salivary gland development
namespace: biological_process
def: "The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell of the salivary gland to attain its fully functional state." [GOC:dph]
is_a: GO:0002070 ! epithelial cell maturation
intersection_of: GO:0002070 ! epithelial cell maturation
intersection_of: part_of GO:0007431 ! salivary gland development
relationship: part_of GO:0007431 ! salivary gland development
relationship: part_of GO:0060690 ! epithelial cell differentiation involved in salivary gland development
created_by: dph
creation_date: 2009-06-08T01:06:00Z

[Term]
id: GO:0060692
name: mesenchymal cell differentiation involved in salivary gland development
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell of the salivary gland. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types." [GOC:dph]
is_a: GO:0048762 ! mesenchymal cell differentiation
is_a: GO:0060689 ! cell differentiation involved in salivary gland development
intersection_of: GO:0048762 ! mesenchymal cell differentiation
intersection_of: part_of GO:0007431 ! salivary gland development
relationship: part_of GO:0007431 ! salivary gland development
created_by: dph
creation_date: 2009-06-08T01:08:44Z

[Term]
id: GO:0060693
name: regulation of branching involved in salivary gland morphogenesis
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of branching morphogenesis in the salivary gland epithelium." [GOC:dph]
is_a: GO:0060688 ! regulation of morphogenesis of a branching structure
is_a: GO:2000027 ! regulation of organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060445 ! branching involved in salivary gland morphogenesis
relationship: regulates GO:0060445 ! branching involved in salivary gland morphogenesis
created_by: dph
creation_date: 2009-06-08T01:14:44Z

[Term]
id: GO:0060694
name: regulation of cholesterol transporter activity
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of cholesterol transporter activity." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0032374 ! regulation of cholesterol transport
is_a: GO:0032409 ! regulation of transporter activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0017127 ! cholesterol transporter activity
relationship: regulates GO:0017127 ! cholesterol transporter activity
created_by: dph
creation_date: 2009-06-08T02:05:27Z

[Term]
id: GO:0060695
name: negative regulation of cholesterol transporter activity
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of cholesterol transporter activity." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0032375 ! negative regulation of cholesterol transport
is_a: GO:0032410 ! negative regulation of transporter activity
is_a: GO:0060694 ! regulation of cholesterol transporter activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0017127 ! cholesterol transporter activity
relationship: negatively_regulates GO:0017127 ! cholesterol transporter activity
created_by: dph
creation_date: 2009-06-08T02:08:34Z

[Term]
id: GO:0060696
name: regulation of phospholipid catabolic process
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of phospholipid catabolism, the chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:0050994 ! regulation of lipid catabolic process
is_a: GO:1903725 ! regulation of phospholipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009395 ! phospholipid catabolic process
relationship: regulates GO:0009395 ! phospholipid catabolic process
created_by: dph
creation_date: 2009-06-08T02:25:45Z

[Term]
id: GO:0060697
name: positive regulation of phospholipid catabolic process
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of phospholipid catabolism, the chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:0050996 ! positive regulation of lipid catabolic process
is_a: GO:0060696 ! regulation of phospholipid catabolic process
is_a: GO:1903727 ! positive regulation of phospholipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009395 ! phospholipid catabolic process
relationship: positively_regulates GO:0009395 ! phospholipid catabolic process
created_by: dph
creation_date: 2009-06-08T02:28:38Z

[Term]
id: GO:0060698
name: endoribonuclease inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of an endoribonuclease, any enzyme that catalyzes the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:dph, GOC:tb]
is_a: GO:0008428 ! ribonuclease inhibitor activity
relationship: negatively_regulates GO:0004521 ! endoribonuclease activity
relationship: part_of GO:0060702 ! negative regulation of endoribonuclease activity
created_by: dph
creation_date: 2009-06-08T02:37:19Z

[Term]
id: GO:0060699
name: regulation of endoribonuclease activity
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:dph, GOC:tb]
is_a: GO:0060700 ! regulation of ribonuclease activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004521 ! endoribonuclease activity
relationship: regulates GO:0004521 ! endoribonuclease activity
created_by: dph
creation_date: 2009-06-08T02:43:10Z

[Term]
id: GO:0060700
name: regulation of ribonuclease activity
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of ribonuclease activity, catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:dph, GOC:tb]
is_a: GO:0032069 ! regulation of nuclease activity
is_a: GO:0051252 ! regulation of RNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004540 ! ribonuclease activity
relationship: regulates GO:0004540 ! ribonuclease activity
created_by: dph
creation_date: 2009-06-08T02:45:46Z

[Term]
id: GO:0060701
name: negative regulation of ribonuclease activity
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of ribonuclease activity, catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:dph, GOC:tb]
is_a: GO:0032074 ! negative regulation of nuclease activity
is_a: GO:0051253 ! negative regulation of RNA metabolic process
is_a: GO:0060700 ! regulation of ribonuclease activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004540 ! ribonuclease activity
relationship: negatively_regulates GO:0004540 ! ribonuclease activity
created_by: dph
creation_date: 2009-06-08T02:49:46Z

[Term]
id: GO:0060702
name: negative regulation of endoribonuclease activity
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:dph, GOC:tb]
is_a: GO:0060699 ! regulation of endoribonuclease activity
is_a: GO:0060701 ! negative regulation of ribonuclease activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004521 ! endoribonuclease activity
relationship: negatively_regulates GO:0004521 ! endoribonuclease activity
created_by: dph
creation_date: 2009-06-08T02:52:27Z

[Term]
id: GO:0060703
name: deoxyribonuclease inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of deoxyribonuclease." [GOC:dph, GOC:tb]
synonym: "DNase inhibitor activity" RELATED [GOC:dph, GOC:tb]
is_a: GO:0004857 ! enzyme inhibitor activity
relationship: negatively_regulates GO:0004536 ! deoxyribonuclease activity
relationship: part_of GO:0032076 ! negative regulation of deoxyribonuclease activity
created_by: dph
creation_date: 2009-06-08T03:00:35Z

[Term]
id: GO:0060704
name: acinar cell differentiation involved in salivary gland development
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features that characterize an acinar cell of the salivary gland. Acinar cells are protein-secreting cells in the gland." [GOC:dph, GOC:tb]
is_a: GO:0060690 ! epithelial cell differentiation involved in salivary gland development
is_a: GO:0090425 ! acinar cell differentiation
intersection_of: GO:0090425 ! acinar cell differentiation
intersection_of: part_of GO:0007431 ! salivary gland development
relationship: part_of GO:0007431 ! salivary gland development
created_by: dph
creation_date: 2009-06-09T09:32:46Z

[Term]
id: GO:0060705
name: neuron differentiation involved in salivary gland development
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features that characterize the neurons of the salivary gland." [GOC:dph]
is_a: GO:0030182 ! neuron differentiation
is_a: GO:0060689 ! cell differentiation involved in salivary gland development
intersection_of: GO:0030182 ! neuron differentiation
intersection_of: part_of GO:0007431 ! salivary gland development
relationship: part_of GO:0007431 ! salivary gland development
created_by: dph
creation_date: 2009-06-09T09:35:52Z

[Term]
id: GO:0060706
name: cell differentiation involved in embryonic placenta development
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of the embryonic placenta." [GOC:dph]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0030154 ! cell differentiation
is_a: GO:0044702 ! single organism reproductive process
intersection_of: GO:0030154 ! cell differentiation
intersection_of: part_of GO:0001892 ! embryonic placenta development
relationship: part_of GO:0001892 ! embryonic placenta development
created_by: dph
creation_date: 2009-06-09T10:26:42Z

[Term]
id: GO:0060707
name: trophoblast giant cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a trophoblast giant cell of the placenta. Trophoblast giant cells are the cell of the placenta that line the maternal decidua." [GOC:dph, PMID:16269175]
is_a: GO:0060706 ! cell differentiation involved in embryonic placenta development
created_by: dph
creation_date: 2009-06-09T10:32:12Z

[Term]
id: GO:0060708
name: spongiotrophoblast differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell of the ectoplacental cone acquires specialized features of a spongiotrophoblast of the placenta. A spongiotrophoblast cell is a basophilic cell." [GOC:dph, PMID:16269175]
synonym: "spongiotrophoblast cell differentiation" EXACT [GOC:cjm]
is_a: GO:0060706 ! cell differentiation involved in embryonic placenta development
relationship: part_of GO:0060712 ! spongiotrophoblast layer development
created_by: dph
creation_date: 2009-06-09T10:38:10Z

[Term]
id: GO:0060709
name: glycogen cell differentiation involved in embryonic placenta development
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a glycogen cell of the placenta. A glycogen cell is a vacuolated glycogen-rich cell that appears in compact cell islets of the spongiotrophoblast layer." [GOC:dph, PMID:16269175]
is_a: GO:0060706 ! cell differentiation involved in embryonic placenta development
relationship: part_of GO:0060712 ! spongiotrophoblast layer development
created_by: dph
creation_date: 2009-06-09T10:41:08Z

[Term]
id: GO:0060710
name: chorio-allantoic fusion
namespace: biological_process
def: "The cell-cell adhesion process in which the cells of the chorion fuse to the cells of the allantois." [GOC:dph]
is_a: GO:0016337 ! single organismal cell-cell adhesion
is_a: GO:0044702 ! single organism reproductive process
relationship: part_of GO:0060713 ! labyrinthine layer morphogenesis
created_by: dph
creation_date: 2009-06-09T03:24:27Z

[Term]
id: GO:0060711
name: labyrinthine layer development
namespace: biological_process
def: "The process in which the labyrinthine layer of the placenta progresses, from its formation to its mature state." [GOC:dph]
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048608 ! reproductive structure development
relationship: part_of GO:0001892 ! embryonic placenta development
created_by: dph
creation_date: 2009-06-09T03:27:43Z

[Term]
id: GO:0060712
name: spongiotrophoblast layer development
namespace: biological_process
def: "The process in which the spongiotrophoblast layer of the placenta progresses from its formation to its mature state." [GOC:dph]
is_a: GO:0009888 ! tissue development
is_a: GO:0048608 ! reproductive structure development
relationship: part_of GO:0001892 ! embryonic placenta development
created_by: dph
creation_date: 2009-06-09T03:33:40Z

[Term]
id: GO:0060713
name: labyrinthine layer morphogenesis
namespace: biological_process
def: "The process in which the labyrinthine layer of the placenta is generated and organized." [GOC:dph]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0060669 ! embryonic placenta morphogenesis
relationship: part_of GO:0060711 ! labyrinthine layer development
created_by: dph
creation_date: 2009-06-10T08:10:19Z

[Term]
id: GO:0060714
name: labyrinthine layer formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the labyrinthine layer of the placenta." [GOC:dph]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0060713 ! labyrinthine layer morphogenesis
created_by: dph
creation_date: 2009-06-10T08:13:14Z

[Term]
id: GO:0060715
name: syncytiotrophoblast cell differentiation involved in labyrinthine layer development
namespace: biological_process
def: "The process in which a chorionic trophoblast cell acquires specialized features of a syncytiotrophoblast of the labyrinthine layer of the placenta." [GOC:dph]
is_a: GO:0060706 ! cell differentiation involved in embryonic placenta development
relationship: part_of GO:0060711 ! labyrinthine layer development
created_by: dph
creation_date: 2009-06-11T08:56:18Z

[Term]
id: GO:0060716
name: labyrinthine layer blood vessel development
namespace: biological_process
def: "The process whose specific outcome is the progression of a blood vessel of the labyrinthine layer of the placenta over time, from its formation to the mature structure. The embryonic vessels grow through the layer to come in close contact with the maternal blood supply." [GOC:dph]
is_a: GO:0048568 ! embryonic organ development
is_a: GO:0048608 ! reproductive structure development
is_a: GO:0060674 ! placenta blood vessel development
relationship: part_of GO:0060711 ! labyrinthine layer development
created_by: dph
creation_date: 2009-06-11T09:04:38Z

[Term]
id: GO:0060717
name: chorion development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a chorion from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The chorion is an extraembryonic membrane." [GOC:dph]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:1903867 ! extraembryonic membrane development
created_by: dph
creation_date: 2009-06-11T02:37:50Z

[Term]
id: GO:0060718
name: chorionic trophoblast cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells of the ectoplacental cone acquire specialized structural and/or functional features that characterize chorionic trophoblasts. These cells will migrate towards the spongiotrophoblast layer and give rise to syncytiotrophoblasts of the labyrinthine layer." [CL:0011101, GOC:dph, PMID:16983341]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0060717 ! chorion development
created_by: dph
creation_date: 2009-06-11T02:48:27Z

[Term]
id: GO:0060719
name: chorionic trophoblast cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of the chorionic trophoblast over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [CL:0011101, GOC:16983341, GOC:dph]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0060718 ! chorionic trophoblast cell differentiation
created_by: dph
creation_date: 2009-06-11T02:58:45Z

[Term]
id: GO:0060720
name: spongiotrophoblast cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of spongiotrophoblast cells, resulting in the expansion of the population in the spongiotrophoblast layer." [GOC:dph]
is_a: GO:0060722 ! cell proliferation involved in embryonic placenta development
relationship: part_of GO:0090214 ! spongiotrophoblast layer developmental growth
created_by: dph
creation_date: 2009-06-11T09:50:35Z

[Term]
id: GO:0060721
name: regulation of spongiotrophoblast cell proliferation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of spongiotrophoblast cell proliferation." [GOC:dph]
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:0060723 ! regulation of cell proliferation involved in embryonic placenta development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060720 ! spongiotrophoblast cell proliferation
relationship: regulates GO:0060720 ! spongiotrophoblast cell proliferation
created_by: dph
creation_date: 2009-06-11T09:57:27Z

[Term]
id: GO:0060722
name: cell proliferation involved in embryonic placenta development
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of the population in the embryonic placenta." [GOC:dph]
is_a: GO:0008283 ! cell proliferation
is_a: GO:0044702 ! single organism reproductive process
intersection_of: GO:0008283 ! cell proliferation
intersection_of: part_of GO:0001892 ! embryonic placenta development
relationship: part_of GO:0001892 ! embryonic placenta development
created_by: dph
creation_date: 2009-06-12T12:46:04Z

[Term]
id: GO:0060723
name: regulation of cell proliferation involved in embryonic placenta development
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of cell proliferation involved in embryonic placenta development." [GOC:dph]
is_a: GO:0042127 ! regulation of cell proliferation
is_a: GO:0045995 ! regulation of embryonic development
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060722 ! cell proliferation involved in embryonic placenta development
relationship: regulates GO:0060722 ! cell proliferation involved in embryonic placenta development
created_by: dph
creation_date: 2009-06-12T12:50:23Z

[Term]
id: GO:0060724
name: coreceptor activity involved in epidermal growth factor receptor signaling pathway
namespace: molecular_function
def: "Combining with an extracellular messenger, and in cooperation with a primary EGF receptor, initiating a change in cell activity through the EGF receptor signaling pathway." [GOC:dph, GOC:tb]
synonym: "coreceptor activity involved in epidermal growth factor receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0015026 ! coreceptor activity
intersection_of: GO:0015026 ! coreceptor activity
intersection_of: part_of GO:0007173 ! epidermal growth factor receptor signaling pathway
relationship: part_of GO:0007173 ! epidermal growth factor receptor signaling pathway
created_by: dph
creation_date: 2009-06-12T01:06:08Z

[Term]
id: GO:0060725
name: regulation of coreceptor activity
namespace: biological_process
def: "Any process that modulates the rate or frequency of coreceptor activity, combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity." [GOC:dph, GOC:tb]
is_a: GO:0010469 ! regulation of receptor activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0015026 ! coreceptor activity
relationship: regulates GO:0015026 ! coreceptor activity
created_by: dph
creation_date: 2009-06-12T01:20:11Z

[Term]
id: GO:0060726
name: regulation of coreceptor activity involved in epidermal growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the rate or frequency of coreceptor activity involved in epidermal growth factor receptor signaling pathway." [GOC:dph, GOC:tb]
synonym: "regulation of coreceptor activity involved in epidermal growth factor receptor signalling pathway" EXACT [GOC:mah]
synonym: "regulation of Neu/ErbB-2 receptor activity" NARROW [GOC:dph, GOC:tb]
is_a: GO:0042058 ! regulation of epidermal growth factor receptor signaling pathway
is_a: GO:0060725 ! regulation of coreceptor activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060724 ! coreceptor activity involved in epidermal growth factor receptor signaling pathway
relationship: regulates GO:0060724 ! coreceptor activity involved in epidermal growth factor receptor signaling pathway
created_by: dph
creation_date: 2009-06-12T01:25:20Z

[Term]
id: GO:0060727
name: positive regulation of coreceptor activity involved in epidermal growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that increases the rate or frequency of coreceptor activity involved in epidermal growth factor receptor signaling pathway." [GOC:dph, GOC:tb]
synonym: "positive regulation of coreceptor activity involved in epidermal growth factor receptor signalling pathway" EXACT [GOC:mah]
synonym: "positive regulation of Neu/ErbB-2 receptor activity" NARROW [GOC:dph, GOC:tb]
is_a: GO:0045742 ! positive regulation of epidermal growth factor receptor signaling pathway
is_a: GO:0060726 ! regulation of coreceptor activity involved in epidermal growth factor receptor signaling pathway
is_a: GO:2000273 ! positive regulation of receptor activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060724 ! coreceptor activity involved in epidermal growth factor receptor signaling pathway
relationship: positively_regulates GO:0060724 ! coreceptor activity involved in epidermal growth factor receptor signaling pathway
created_by: dph
creation_date: 2009-06-12T01:30:50Z

[Term]
id: GO:0060728
name: negative regulation of coreceptor activity involved in epidermal growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that decreases the rate or frequency of coreceptor activity involved in epidermal growth factor receptor signaling pathway." [GOC:dph, GOC:tb]
synonym: "negative regulation of coreceptor activity involved in epidermal growth factor receptor signalling pathway" EXACT [GOC:mah]
synonym: "negative regulation of Neu/ErbB-2 receptor activity" NARROW [GOC:dph, GOC:tb]
is_a: GO:0042059 ! negative regulation of epidermal growth factor receptor signaling pathway
is_a: GO:0060726 ! regulation of coreceptor activity involved in epidermal growth factor receptor signaling pathway
is_a: GO:2000272 ! negative regulation of receptor activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060724 ! coreceptor activity involved in epidermal growth factor receptor signaling pathway
relationship: negatively_regulates GO:0060724 ! coreceptor activity involved in epidermal growth factor receptor signaling pathway
created_by: dph
creation_date: 2009-06-12T01:32:38Z

[Term]
id: GO:0060729
name: intestinal epithelial structure maintenance
namespace: biological_process
def: "A tissue homeostatic process required for the maintenance of the structure of the intestinal epithelium." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "epithelial structure maintenance of intestine" EXACT [GOC:dph, GOC:tb]
synonym: "maintenance of intestinal epithelium" EXACT [GOC:dph, GOC:tb]
is_a: GO:0030277 ! maintenance of gastrointestinal epithelium
created_by: dph
creation_date: 2009-06-12T01:44:52Z

[Term]
id: GO:0060730
name: regulation of intestinal epithelial structure maintenance
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of intestinal epithelial structure maintenance, a tissue homeostatic process required for the maintenance of the structure of the intestinal epithelium." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0032844 ! regulation of homeostatic process
is_a: GO:0044058 ! regulation of digestive system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060729 ! intestinal epithelial structure maintenance
relationship: regulates GO:0060729 ! intestinal epithelial structure maintenance
created_by: dph
creation_date: 2009-06-12T01:49:34Z

[Term]
id: GO:0060731
name: positive regulation of intestinal epithelial structure maintenance
namespace: biological_process
def: "Any process the increases the rate, frequency or extent of intestinal epithelial structure maintenance, a tissue homeostatic process required for the maintenance of the structure of the intestinal epithelium." [GOC:dph, GOC:tb]
is_a: GO:0032846 ! positive regulation of homeostatic process
is_a: GO:0060456 ! positive regulation of digestive system process
is_a: GO:0060730 ! regulation of intestinal epithelial structure maintenance
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060729 ! intestinal epithelial structure maintenance
relationship: positively_regulates GO:0060729 ! intestinal epithelial structure maintenance
created_by: dph
creation_date: 2009-06-12T01:51:50Z

[Term]
id: GO:0060732
name: positive regulation of inositol phosphate biosynthetic process
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of inositol phosphate biosynthesis. Inositol phosphate biosynthetic processes are the chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [GOC:dph, GOC:tb]
is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process
is_a: GO:0010919 ! regulation of inositol phosphate biosynthetic process
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0045937 ! positive regulation of phosphate metabolic process
is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032958 ! inositol phosphate biosynthetic process
relationship: positively_regulates GO:0032958 ! inositol phosphate biosynthetic process
created_by: dph
creation_date: 2009-06-12T01:58:23Z

[Term]
id: GO:0060733
name: regulation of eIF2 alpha phosphorylation by amino acid starvation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a cellular response to amino acid starvation." [GOC:dph, GOC:tb]
is_a: GO:0001932 ! regulation of protein phosphorylation
is_a: GO:0006446 ! regulation of translational initiation
is_a: GO:0034198 ! cellular response to amino acid starvation
is_a: GO:0080135 ! regulation of cellular response to stress
relationship: regulates GO:0010998 ! regulation of translational initiation by eIF2 alpha phosphorylation
created_by: dph
creation_date: 2009-06-12T02:08:50Z

[Term]
id: GO:0060734
name: regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a cellular response to endoplasmic reticulum stress." [GOC:dph, GOC:tb]
synonym: "regulation of eIF2 alpha phosphorylation by endoplasmic reticulum stress" EXACT []
synonym: "regulation of eIF2 alpha phosphorylation by ER stress" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of ER stress-induced eIF2 alpha phosphorylation" EXACT [GOC:bf]
is_a: GO:0001932 ! regulation of protein phosphorylation
is_a: GO:0006446 ! regulation of translational initiation
is_a: GO:0080135 ! regulation of cellular response to stress
relationship: regulates GO:0034976 ! response to endoplasmic reticulum stress
relationship: regulates GO:0036492 ! eiF2alpha phosphorylation in response to endoplasmic reticulum stress
created_by: dph
creation_date: 2009-06-12T02:15:16Z

[Term]
id: GO:0060735
name: regulation of eIF2 alpha phosphorylation by dsRNA
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a cellular response to double-stranded RNA." [GOC:dph, GOC:tb]
synonym: "regulation of eIF2 alpha phosphorylation by double-stranded RNA" EXACT [GOC:dph]
synonym: "regulation of eIF2 alpha phosphorylation by PKR" NARROW [GOC:dph, GOC:tb]
is_a: GO:0001932 ! regulation of protein phosphorylation
is_a: GO:0006446 ! regulation of translational initiation
is_a: GO:0080135 ! regulation of cellular response to stress
relationship: part_of GO:0071359 ! cellular response to dsRNA
relationship: regulates GO:0010998 ! regulation of translational initiation by eIF2 alpha phosphorylation
created_by: dph
creation_date: 2009-06-12T02:27:14Z

[Term]
id: GO:0060736
name: prostate gland growth
namespace: biological_process
def: "The increase in size or mass of the prostate gland where the increase in size or mass has the specific outcome of the progression of the gland, from its formation to its mature state." [GOC:dph]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0035265 ! organ growth
is_a: GO:0044702 ! single organism reproductive process
relationship: part_of GO:0030850 ! prostate gland development
created_by: dph
creation_date: 2009-06-15T09:21:52Z

[Term]
id: GO:0060737
name: prostate gland morphogenetic growth
namespace: biological_process
def: "The differential increase in size or mass of the prostate gland that contributes to the gland attaining its form." [GOC:dph]
synonym: "prostate gland growth involved in morphogenesis" EXACT [GOC:dph]
is_a: GO:0060560 ! developmental growth involved in morphogenesis
is_a: GO:0060736 ! prostate gland growth
intersection_of: GO:0060736 ! prostate gland growth
intersection_of: part_of GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0060512 ! prostate gland morphogenesis
created_by: dph
creation_date: 2009-06-15T09:24:40Z

[Term]
id: GO:0060738
name: epithelial-mesenchymal signaling involved in prostate gland development
namespace: biological_process
def: "Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell where it is interpreted and contributes to the progression of the prostate gland over time." [GOC:dph]
synonym: "epithelial-mesenchymal signalling involved in prostate gland development" EXACT [GOC:mah]
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0060684 ! epithelial-mesenchymal cell signaling
intersection_of: GO:0060684 ! epithelial-mesenchymal cell signaling
intersection_of: part_of GO:0030850 ! prostate gland development
relationship: part_of GO:0030850 ! prostate gland development
created_by: dph
creation_date: 2009-06-15T09:31:31Z

[Term]
id: GO:0060739
name: mesenchymal-epithelial cell signaling involved in prostate gland development
namespace: biological_process
def: "Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell where it is received and interpreted contributing to the progression of the prostate gland over time." [GOC:dph]
synonym: "mesenchymal-epithelial cell signalling involved in prostate gland development" EXACT [GOC:mah]
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0060638 ! mesenchymal-epithelial cell signaling
intersection_of: GO:0060638 ! mesenchymal-epithelial cell signaling
intersection_of: part_of GO:0030850 ! prostate gland development
relationship: part_of GO:0030850 ! prostate gland development
created_by: dph
creation_date: 2009-06-15T09:35:08Z

[Term]
id: GO:0060740
name: prostate gland epithelium morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of epithelia of the prostate gland are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph]
is_a: GO:0002009 ! morphogenesis of an epithelium
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
relationship: part_of GO:0060512 ! prostate gland morphogenesis
created_by: dph
creation_date: 2009-06-16T09:23:22Z

[Term]
id: GO:0060741
name: prostate gland stromal morphogenesis
namespace: biological_process
def: "The process in which the prostate gland stroma is generated and organized. The prostate gland stroma is made up of the mesenchymal or fibroblast cells of the prostate gland." [GOC:dph]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0060512 ! prostate gland morphogenesis
relationship: part_of GO:0061448 ! connective tissue development
created_by: dph
creation_date: 2009-06-16T09:27:01Z

[Term]
id: GO:0060742
name: epithelial cell differentiation involved in prostate gland development
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell of the prostate gland." [GOC:dph]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0030855 ! epithelial cell differentiation
is_a: GO:0044702 ! single organism reproductive process
intersection_of: GO:0030855 ! epithelial cell differentiation
intersection_of: part_of GO:0030850 ! prostate gland development
relationship: part_of GO:0030850 ! prostate gland development
created_by: dph
creation_date: 2009-06-16T09:32:34Z

[Term]
id: GO:0060743
name: epithelial cell maturation involved in prostate gland development
namespace: biological_process
def: "The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell of the prostate gland to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph]
synonym: "prostate gland epithelial cell development" EXACT [GOC:dph]
is_a: GO:0002070 ! epithelial cell maturation
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
intersection_of: GO:0002070 ! epithelial cell maturation
intersection_of: part_of GO:0030850 ! prostate gland development
relationship: part_of GO:0030850 ! prostate gland development
relationship: part_of GO:0060742 ! epithelial cell differentiation involved in prostate gland development
created_by: dph
creation_date: 2009-06-16T09:34:42Z

[Term]
id: GO:0060744
name: mammary gland branching involved in thelarche
namespace: biological_process
def: "The process in which the branching structure of the mammary gland duct is generated and organized during the period of sexual maturity in mammals. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk." [GOC:dph, PMID:19261859]
synonym: "mammary gland branching involved in puberty" RELATED [GOC:dph]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0060444 ! branching involved in mammary gland duct morphogenesis
intersection_of: GO:0060444 ! branching involved in mammary gland duct morphogenesis
intersection_of: part_of GO:0042695 ! thelarche
relationship: part_of GO:0042695 ! thelarche
created_by: dph
creation_date: 2009-06-22T08:12:17Z

[Term]
id: GO:0060745
name: mammary gland branching involved in pregnancy
namespace: biological_process
def: "The process in which the branching structure of the mammary gland duct is generated and organized as a part of pregnancy." [GOC:dph, PMID:19261859]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0060135 ! maternal process involved in female pregnancy
is_a: GO:0060444 ! branching involved in mammary gland duct morphogenesis
created_by: dph
creation_date: 2009-06-22T08:25:19Z

[Term]
id: GO:0060746
name: parental behavior
namespace: biological_process
def: "A reproductive behavior in which a parent cares for and rears offspring." [GOC:dph]
is_a: GO:0019098 ! reproductive behavior
created_by: dph
creation_date: 2009-06-22T09:05:26Z

[Term]
id: GO:0060747
name: oral incubation
namespace: biological_process
def: "A parental behavior in which fertilized eggs are taken into the mouth and held until hatching." [GOC:dph]
is_a: GO:0060746 ! parental behavior
created_by: dph
creation_date: 2009-06-22T09:08:58Z

[Term]
id: GO:0060748
name: tertiary branching involved in mammary gland duct morphogenesis
namespace: biological_process
def: "The branching process in which the mammary gland ducts form tertiary branches off of the secondary branches as part of diestrus and pregnancy." [GOC:dph, PMID:18614704]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0060444 ! branching involved in mammary gland duct morphogenesis
relationship: part_of GO:0060745 ! mammary gland branching involved in pregnancy
created_by: dph
creation_date: 2009-06-22T10:44:51Z

[Term]
id: GO:0060749
name: mammary gland alveolus development
namespace: biological_process
def: "The progression of the mammary gland alveolus over time, from its formation to its mature state. The mammary gland alveolus is a sac-like structure that is found in the mature gland." [GOC:dph]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0061377 ! mammary gland lobule development
created_by: dph
creation_date: 2009-06-22T10:52:12Z

[Term]
id: GO:0060750
name: epithelial cell proliferation involved in mammary gland duct elongation
namespace: biological_process
def: "The multiplication or reproduction of mammary gland branch epithelial cells, resulting in the elongation of the branch. The mammary gland branch differs from the bud in that it is not the initial curved portion of the outgrowth." [GOC:dph]
is_a: GO:0033598 ! mammary gland epithelial cell proliferation
intersection_of: GO:0033598 ! mammary gland epithelial cell proliferation
intersection_of: part_of GO:0060751 ! branch elongation involved in mammary gland duct branching
relationship: part_of GO:0060751 ! branch elongation involved in mammary gland duct branching
created_by: dph
creation_date: 2009-06-22T10:58:12Z

[Term]
id: GO:0060751
name: branch elongation involved in mammary gland duct branching
namespace: biological_process
def: "The developmental growth process in which a branch of a mammary gland duct elongates." [GOC:dph]
synonym: "mammary gland duct branch elongation" EXACT [GOC:dph]
is_a: GO:0060602 ! branch elongation of an epithelium
intersection_of: GO:0060602 ! branch elongation of an epithelium
intersection_of: part_of GO:0060603 ! mammary gland duct morphogenesis
relationship: part_of GO:0060444 ! branching involved in mammary gland duct morphogenesis
relationship: part_of GO:0060603 ! mammary gland duct morphogenesis
created_by: dph
creation_date: 2009-06-22T11:02:44Z

[Term]
id: GO:0060752
name: intestinal phytosterol absorption
namespace: biological_process
def: "Any process in which phytosterols are taken up from the contents of the intestine." [GOC:dph, GOC:tb]
is_a: GO:0015918 ! sterol transport
is_a: GO:0098856 ! intestinal lipid absorption
created_by: dph
creation_date: 2009-06-22T02:08:43Z

[Term]
id: GO:0060753
name: regulation of mast cell chemotaxis
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of mast cell chemotaxis. Mast cell chemotaxis is the movement of a mast cell in response to an external stimulus." [GOC:dph, GOC:tb]
is_a: GO:0002688 ! regulation of leukocyte chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002551 ! mast cell chemotaxis
relationship: regulates GO:0002551 ! mast cell chemotaxis
created_by: dph
creation_date: 2009-06-22T02:36:06Z

[Term]
id: GO:0060754
name: positive regulation of mast cell chemotaxis
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of mast cell chemotaxis. Mast cell chemotaxis is the movement of a mast cell in response to an external stimulus." [GOC:dph, GOC:tb]
is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis
is_a: GO:0060753 ! regulation of mast cell chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002551 ! mast cell chemotaxis
relationship: positively_regulates GO:0002551 ! mast cell chemotaxis
created_by: dph
creation_date: 2009-06-22T02:38:19Z

[Term]
id: GO:0060755
name: negative regulation of mast cell chemotaxis
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of mast cell chemotaxis. Mast cell chemotaxis is the movement of a mast cell in response to an external stimulus." [GOC:dph, GOC:tb]
is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis
is_a: GO:0060753 ! regulation of mast cell chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002551 ! mast cell chemotaxis
relationship: negatively_regulates GO:0002551 ! mast cell chemotaxis
created_by: dph
creation_date: 2009-06-22T02:40:58Z

[Term]
id: GO:0060756
name: foraging behavior
namespace: biological_process
def: "Behavior by which an organism locates food." [GOC:dph, GOC:tb]
is_a: GO:0044708 ! single-organism behavior
created_by: dph
creation_date: 2009-06-22T02:46:25Z

[Term]
id: GO:0060757
name: adult foraging behavior
namespace: biological_process
def: "Behavior by which an adult locates food." [GOC:dph, GOC:tb]
is_a: GO:0060756 ! foraging behavior
created_by: dph
creation_date: 2009-06-22T02:50:56Z

[Term]
id: GO:0060758
name: foraging behavior by probing substrate
namespace: biological_process
def: "Foraging behavior in which an anatomical part of the organism is inserted into the substrate to locate food." [GOC:dph, GOC:tb]
is_a: GO:0060756 ! foraging behavior
created_by: dph
creation_date: 2009-06-22T02:53:09Z

[Term]
id: GO:0060759
name: regulation of response to cytokine stimulus
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of a response to cytokine stimulus." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0048583 ! regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034097 ! response to cytokine
relationship: regulates GO:0034097 ! response to cytokine
created_by: dph
creation_date: 2009-06-22T02:56:12Z

[Term]
id: GO:0060760
name: positive regulation of response to cytokine stimulus
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of a response to cytokine stimulus." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:0060759 ! regulation of response to cytokine stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034097 ! response to cytokine
relationship: positively_regulates GO:0034097 ! response to cytokine
created_by: dph
creation_date: 2009-06-22T02:58:04Z

[Term]
id: GO:0060761
name: negative regulation of response to cytokine stimulus
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of a response to cytokine stimulus." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:0060759 ! regulation of response to cytokine stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034097 ! response to cytokine
relationship: negatively_regulates GO:0034097 ! response to cytokine
created_by: dph
creation_date: 2009-06-22T02:59:57Z

[Term]
id: GO:0060762
name: regulation of branching involved in mammary gland duct morphogenesis
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of branching involved in mammary gland duct morphogenesis." [GOC:dph]
is_a: GO:0060688 ! regulation of morphogenesis of a branching structure
is_a: GO:2000027 ! regulation of organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060444 ! branching involved in mammary gland duct morphogenesis
relationship: regulates GO:0060444 ! branching involved in mammary gland duct morphogenesis
created_by: dph
creation_date: 2009-06-22T05:20:33Z

[Term]
id: GO:0060763
name: mammary duct terminal end bud growth
namespace: biological_process
def: "The morphogenetic growth of the large, club-shaped terminal end of a mammary gland duct during prepubertal growth and during puberty." [GOC:dph, PMID:10804170]
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0060603 ! mammary gland duct morphogenesis
created_by: dph
creation_date: 2009-07-06T07:33:50Z

[Term]
id: GO:0060764
name: cell-cell signaling involved in mammary gland development
namespace: biological_process
def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the mammary gland, from its initial state to the mature structure." [GOC:dph]
synonym: "cell-cell signalling involved in mammary gland development" EXACT [GOC:mah]
is_a: GO:0007267 ! cell-cell signaling
intersection_of: GO:0007267 ! cell-cell signaling
intersection_of: part_of GO:0030879 ! mammary gland development
relationship: part_of GO:0030879 ! mammary gland development
created_by: dph
creation_date: 2009-07-06T09:24:53Z

[Term]
id: GO:0060765
name: regulation of androgen receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the androgen receptor signaling pathway." [GOC:dph]
synonym: "regulation of androgen receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0033143 ! regulation of intracellular steroid hormone receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030521 ! androgen receptor signaling pathway
relationship: regulates GO:0030521 ! androgen receptor signaling pathway
created_by: dph
creation_date: 2009-07-06T11:07:38Z

[Term]
id: GO:0060766
name: negative regulation of androgen receptor signaling pathway
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the androgen receptor signaling pathway." [GOC:dph]
synonym: "negative regulation of androgen receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0033144 ! negative regulation of intracellular steroid hormone receptor signaling pathway
is_a: GO:0060765 ! regulation of androgen receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030521 ! androgen receptor signaling pathway
relationship: negatively_regulates GO:0030521 ! androgen receptor signaling pathway
created_by: dph
creation_date: 2009-07-06T11:09:36Z

[Term]
id: GO:0060767
name: epithelial cell proliferation involved in prostate gland development
namespace: biological_process
def: "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the progression of the prostate gland over time." [GOC:dph]
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0050673 ! epithelial cell proliferation
intersection_of: GO:0050673 ! epithelial cell proliferation
intersection_of: part_of GO:0030850 ! prostate gland development
relationship: part_of GO:0030850 ! prostate gland development
created_by: dph
creation_date: 2009-07-08T07:32:34Z

[Term]
id: GO:0060768
name: regulation of epithelial cell proliferation involved in prostate gland development
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of epithelial cell proliferation that contributes to the progression of the prostate gland over time." [GOC:dph]
is_a: GO:0050678 ! regulation of epithelial cell proliferation
is_a: GO:2000026 ! regulation of multicellular organismal development
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060767 ! epithelial cell proliferation involved in prostate gland development
relationship: regulates GO:0060767 ! epithelial cell proliferation involved in prostate gland development
created_by: dph
creation_date: 2009-07-08T07:34:56Z

[Term]
id: GO:0060769
name: positive regulation of epithelial cell proliferation involved in prostate gland development
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of epithelial cell proliferation that contributes to the progression of the prostate gland over time." [GOC:dph]
is_a: GO:0050679 ! positive regulation of epithelial cell proliferation
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0060768 ! regulation of epithelial cell proliferation involved in prostate gland development
is_a: GO:2000243 ! positive regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060767 ! epithelial cell proliferation involved in prostate gland development
relationship: positively_regulates GO:0060767 ! epithelial cell proliferation involved in prostate gland development
created_by: dph
creation_date: 2009-07-08T07:38:02Z

[Term]
id: GO:0060770
name: negative regulation of epithelial cell proliferation involved in prostate gland development
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of epithelial cell proliferation that contributes to the progression of the prostate gland over time." [GOC:dph]
is_a: GO:0050680 ! negative regulation of epithelial cell proliferation
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0060768 ! regulation of epithelial cell proliferation involved in prostate gland development
is_a: GO:2000242 ! negative regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060767 ! epithelial cell proliferation involved in prostate gland development
relationship: negatively_regulates GO:0060767 ! epithelial cell proliferation involved in prostate gland development
created_by: dph
creation_date: 2009-07-08T07:40:27Z

[Term]
id: GO:0060771
name: phyllotactic patterning
namespace: biological_process
def: "The radial pattern formation process that results in the formation of plant organs (leaves or leaf-like structures) or flower primordia around a central axis." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0009956 ! radial pattern formation
created_by: dph
creation_date: 2009-07-25T06:20:33Z

[Term]
id: GO:0060772
name: leaf phyllotactic patterning
namespace: biological_process
def: "The radial pattern formation process that results in the formation of leaf primordia around the center of a shoot apical meristem." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060771 ! phyllotactic patterning
created_by: dph
creation_date: 2009-07-25T06:27:15Z

[Term]
id: GO:0060773
name: flower phyllotactic patterning
namespace: biological_process
def: "The radial pattern formation process that results in the formation of floral organ primordia around a central axis in a flower primordium." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060771 ! phyllotactic patterning
created_by: dph
creation_date: 2009-07-25T06:28:38Z

[Term]
id: GO:0060774
name: auxin mediated signaling pathway involved in phyllotactic patterning
namespace: biological_process
def: "The series of molecular signals generated in response to detection of auxin that contributes to the radial pattern formation process resulting in the formation of leaf or flower primordia around the center of a shoot apical meristem." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "auxin mediated signalling pathway involved in phyllotactic patterning" EXACT [GOC:mah]
is_a: GO:0009734 ! auxin-activated signaling pathway
intersection_of: GO:0009734 ! auxin-activated signaling pathway
intersection_of: part_of GO:0060771 ! phyllotactic patterning
relationship: part_of GO:0060771 ! phyllotactic patterning
created_by: dph
creation_date: 2009-07-25T06:31:13Z

[Term]
id: GO:0060775
name: planar cell polarity pathway involved in gastrula mediolateral intercalation
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) contributing to the interdigitation of cells along the mediolateral axis during gastrulation." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0044333 ! Wnt signaling pathway involved in digestive tract morphogenesis
is_a: GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway
relationship: part_of GO:0060031 ! mediolateral intercalation
created_by: dph
creation_date: 2009-07-25T06:52:50Z

[Term]
id: GO:0060776
name: simple leaf morphogenesis
namespace: biological_process
def: "The leaf morphogenesis process which results in the shaping of a simple leaf. A simple leaf is a leaf in which the lamina is undivided." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0009965 ! leaf morphogenesis
created_by: dph
creation_date: 2009-07-25T07:08:44Z

[Term]
id: GO:0060777
name: compound leaf morphogenesis
namespace: biological_process
def: "The leaf morphogenesis process that results in the shaping of a compound leaf. A compound leaf is a leaf having two or more distinct leaflets that are evident as such from early in development." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0009965 ! leaf morphogenesis
created_by: dph
creation_date: 2009-07-25T07:12:30Z

[Term]
id: GO:0060778
name: primary leaflet morphogenesis
namespace: biological_process
def: "The process in which the primary leaflet attains its shape. A primary leaflet is a leaflet that develops directly from the rachis." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060794 ! leaflet morphogenesis
created_by: dph
creation_date: 2009-07-25T07:15:48Z

[Term]
id: GO:0060779
name: secondary leaflet morphogenesis
namespace: biological_process
def: "The process in which the secondary leaflet attains its shape. A secondary leaflet develops by branching or division of a primary leaflet." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060794 ! leaflet morphogenesis
created_by: dph
creation_date: 2009-07-25T07:19:02Z

[Term]
id: GO:0060780
name: intercalary leaflet morphogenesis
namespace: biological_process
def: "The process in which the intercalary leaflet attains its shape. An intercalary leaflet is a leaflet that develops between primary leaflets." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060794 ! leaflet morphogenesis
created_by: dph
creation_date: 2009-07-25T07:20:46Z

[Term]
id: GO:0060781
name: mesenchymal cell proliferation involved in prostate gland development
namespace: biological_process
def: "The multiplication or reproduction of mesenchymal cells, resulting in the expansion of a cell population that contributes to the progression of the prostate gland over time." [GOC:dph, PMID:12221011]
is_a: GO:0010463 ! mesenchymal cell proliferation
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0044763 ! single-organism cellular process
intersection_of: GO:0010463 ! mesenchymal cell proliferation
intersection_of: part_of GO:0030850 ! prostate gland development
relationship: part_of GO:0030850 ! prostate gland development
created_by: dph
creation_date: 2009-07-28T11:50:56Z

[Term]
id: GO:0060782
name: regulation of mesenchymal cell proliferation involved in prostate gland development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation that contributes to the progression of the prostate gland over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:dph, PMID:12221011]
is_a: GO:0010464 ! regulation of mesenchymal cell proliferation
is_a: GO:2000026 ! regulation of multicellular organismal development
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060781 ! mesenchymal cell proliferation involved in prostate gland development
relationship: regulates GO:0060781 ! mesenchymal cell proliferation involved in prostate gland development
created_by: dph
creation_date: 2009-07-28T11:54:20Z

[Term]
id: GO:0060783
name: mesenchymal smoothened signaling pathway involved in prostate gland development
namespace: biological_process
def: "The series of molecular signals generated as a consequence of activation of the transmembrane Smoothened-type protein in the mesenchymal cells of the prostate that contribute to the progression of the prostate over time. This process contributes to lung development." [PMID:12221011]
synonym: "mesenchymal hedgehog signaling pathway involved in prostate gland development" EXACT [GOC:bf, GOC:ecd]
synonym: "mesenchymal hh signaling pathway involved in prostate gland development" EXACT [GOC:bf, GOC:ecd]
synonym: "mesenchymal smoothened signalling pathway involved in prostate gland development" EXACT [GOC:mah]
is_a: GO:0007224 ! smoothened signaling pathway
is_a: GO:0022414 ! reproductive process
is_a: GO:1905114 ! cell surface receptor signaling pathway involved in cell-cell signaling
relationship: part_of GO:0060738 ! epithelial-mesenchymal signaling involved in prostate gland development
created_by: dph
creation_date: 2009-07-28T11:57:59Z

[Term]
id: GO:0060784
name: regulation of cell proliferation involved in tissue homeostasis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell proliferation resulting in the maintenance of a steady-state number of cells within a tissue." [GOC:dph]
is_a: GO:0042127 ! regulation of cell proliferation
intersection_of: GO:0042127 ! regulation of cell proliferation
intersection_of: part_of GO:0001894 ! tissue homeostasis
relationship: part_of GO:0001894 ! tissue homeostasis
relationship: part_of GO:0048873 ! homeostasis of number of cells within a tissue
created_by: dph
creation_date: 2009-07-31T01:46:28Z

[Term]
id: GO:0060785
name: regulation of apoptosis involved in tissue homeostasis
namespace: biological_process
def: "Any process that modulates the occurrence or rate of cell death by apoptosis that results in the maintenance of the steady-state number of cells within a tissue." [GOC:dph]
is_a: GO:0042981 ! regulation of apoptotic process
intersection_of: GO:0042981 ! regulation of apoptotic process
intersection_of: part_of GO:0001894 ! tissue homeostasis
relationship: part_of GO:0001894 ! tissue homeostasis
relationship: part_of GO:0048873 ! homeostasis of number of cells within a tissue
created_by: dph
creation_date: 2009-07-31T01:49:54Z

[Term]
id: GO:0060786
name: regulation of cell differentiation involved in tissue homeostasis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell differentiation that contributes to the maintenance of a steady state of a cell type within a tissue." [GOC:dph]
is_a: GO:0045595 ! regulation of cell differentiation
intersection_of: GO:0045595 ! regulation of cell differentiation
intersection_of: part_of GO:0001894 ! tissue homeostasis
relationship: part_of GO:0001894 ! tissue homeostasis
relationship: part_of GO:0048873 ! homeostasis of number of cells within a tissue
created_by: dph
creation_date: 2009-07-31T01:55:19Z

[Term]
id: GO:0060787
name: positive regulation of posterior neural plate formation by fibroblast growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that increases the rate or extent of the formation of the posterior neural plate, the posterior end of the flat, thickened layer of ectodermal cells known as the neural plate." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "positive regulation of posterior neural plate formation by FGF receptor signaling pathway" RELATED [GOC:dph, GOC:tb]
synonym: "positive regulation of posterior neural plate formation by fibroblast growth factor receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway
is_a: GO:0040019 ! positive regulation of embryonic development
is_a: GO:2000027 ! regulation of organ morphogenesis
relationship: positively_regulates GO:0090018 ! posterior neural plate formation
created_by: dph
creation_date: 2009-08-04T09:48:31Z

[Term]
id: GO:0060788
name: ectodermal placode formation
namespace: biological_process
def: "The developmental process in which an ectodermal placode forms. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0071697 ! ectodermal placode morphogenesis
created_by: dph
creation_date: 2009-08-04T12:15:57Z

[Term]
id: GO:0060789
name: hair follicle placode formation
namespace: biological_process
def: "The developmental process in which a hair placode forms. An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060788 ! ectodermal placode formation
relationship: part_of GO:0001942 ! hair follicle development
created_by: dph
creation_date: 2009-08-04T12:18:26Z

[Term]
id: GO:0060790
name: tooth placode formation
namespace: biological_process
def: "The developmental process in which the tooth placode forms. A tooth placode is a thickening of the ectoderm that will give rise to the tooth bud." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060788 ! ectodermal placode formation
relationship: part_of GO:0042475 ! odontogenesis of dentin-containing tooth
created_by: dph
creation_date: 2009-08-04T12:21:47Z

[Term]
id: GO:0060791
name: sebaceous gland placode formation
namespace: biological_process
def: "The developmental process in which a sebaceous gland placode forms. A sebaceous gland placode is a thickening of the ectoderm that will give rise to the sebaceous gland bud." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060788 ! ectodermal placode formation
relationship: part_of GO:0048733 ! sebaceous gland development
created_by: dph
creation_date: 2009-08-04T12:23:09Z

[Term]
id: GO:0060792
name: sweat gland development
namespace: biological_process
def: "The progression of the sweat gland over time, from its formation to the mature structure. Sweat glands secrete an aqueous solution that is used in thermoregulation." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0048732 ! gland development
created_by: dph
creation_date: 2009-08-04T12:35:12Z

[Term]
id: GO:0060793
name: sweat gland placode formation
namespace: biological_process
def: "The developmental process in which the sweat gland placode forms. An sweat gland placode is a thickening of the ectoderm that will give rise to the sweat gland bud." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060788 ! ectodermal placode formation
relationship: part_of GO:0060792 ! sweat gland development
created_by: dph
creation_date: 2009-08-04T12:38:10Z

[Term]
id: GO:0060794
name: leaflet morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the leaflet are generated and organized." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0060777 ! compound leaf morphogenesis
created_by: dph
creation_date: 2009-08-04T02:58:14Z

[Term]
id: GO:0060795
name: cell fate commitment involved in formation of primary germ layer
namespace: biological_process
def: "The commitment of cells to specific cell fates of the endoderm, ectoderm, or mesoderm as a part of gastrulation." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0045165 ! cell fate commitment
intersection_of: GO:0045165 ! cell fate commitment
intersection_of: part_of GO:0001704 ! formation of primary germ layer
relationship: part_of GO:0001704 ! formation of primary germ layer
created_by: dph
creation_date: 2009-08-04T03:11:22Z

[Term]
id: GO:0060796
name: regulation of transcription involved in primary germ layer cell fate commitment
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results in cells adopting an endoderm, ectoderm or mesoderm cell fate." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060850 ! regulation of transcription involved in cell fate commitment
intersection_of: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
intersection_of: part_of GO:0060795 ! cell fate commitment involved in formation of primary germ layer
relationship: part_of GO:0060795 ! cell fate commitment involved in formation of primary germ layer
created_by: dph
creation_date: 2009-08-04T03:40:21Z

[Term]
id: GO:0060797
name: transforming growth factor beta receptor signaling pathway involved in primary germ layer cell fate commitment
namespace: biological_process
def: "A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, which contributes to an unspecified cell adopting a mesoderm fate." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "transforming growth factor beta receptor signalling pathway involved in primary germ layer cell fate commitment" EXACT [GOC:mah]
is_a: GO:0007179 ! transforming growth factor beta receptor signaling pathway
relationship: part_of GO:0060795 ! cell fate commitment involved in formation of primary germ layer
created_by: dph
creation_date: 2009-08-04T03:41:44Z

[Term]
id: GO:0060798
name: transforming growth factor beta receptor signaling pathway involved in mesodermal cell fate specification
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands and ultimately resulting in the specification of a mesodermal fate." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "transforming growth factor beta receptor signalling pathway involved in mesodermal cell fate specification" EXACT [GOC:mah]
is_a: GO:0060797 ! transforming growth factor beta receptor signaling pathway involved in primary germ layer cell fate commitment
intersection_of: GO:0007179 ! transforming growth factor beta receptor signaling pathway
intersection_of: part_of GO:0007501 ! mesodermal cell fate specification
relationship: part_of GO:0007501 ! mesodermal cell fate specification
created_by: dph
creation_date: 2009-08-06T11:16:11Z

[Term]
id: GO:0060799
name: transforming growth factor beta receptor signaling pathway involved in endodermal cell fate specification
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands and ultimately resulting in the commitment of an unspecified fate to adopt an endoderm fate." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "transforming growth factor beta receptor signalling pathway involved in endodermal cell fate specification" EXACT [GOC:mah]
is_a: GO:0060797 ! transforming growth factor beta receptor signaling pathway involved in primary germ layer cell fate commitment
intersection_of: GO:0007179 ! transforming growth factor beta receptor signaling pathway
intersection_of: part_of GO:0001714 ! endodermal cell fate specification
relationship: part_of GO:0001714 ! endodermal cell fate specification
created_by: dph
creation_date: 2009-08-06T11:24:01Z

[Term]
id: GO:0060800
name: regulation of cell differentiation involved in embryonic placenta development
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of cell differentiation that contributes to the progression of the placenta over time, from its initial condition to its mature state." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:0045995 ! regulation of embryonic development
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060706 ! cell differentiation involved in embryonic placenta development
relationship: regulates GO:0060706 ! cell differentiation involved in embryonic placenta development
created_by: dph
creation_date: 2009-08-06T01:20:25Z

[Term]
id: GO:0060801
name: negative regulation of trophoblast cell differentiation by transforming growth factor beta signaling pathway
namespace: biological_process
def: "The transforming growth factor signaling process that decreases the rate, frequency, or extent of trophoblast stem cells differentiating into the more mature cells of the trophoblast." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "negative regulation of trophoblast cell differentiation by transforming growth factor beta signalling pathway" EXACT [GOC:mah]
is_a: GO:0060806 ! negative regulation of cell differentiation involved in embryonic placenta development
created_by: dph
creation_date: 2009-08-06T01:24:24Z

[Term]
id: GO:0060802
name: epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification
namespace: biological_process
def: "Any process that mediates the transfer of information from an epiblast cell to an extraembryonic ectoderm cell that contributes to the specification of the anterior/posterior axis." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "epiblast cell-extraembryonic ectoderm cell signalling involved in anterior/posterior axis specification" EXACT [GOC:mah]
is_a: GO:0007267 ! cell-cell signaling
relationship: part_of GO:0009948 ! anterior/posterior axis specification
created_by: dph
creation_date: 2009-08-06T01:36:13Z

[Term]
id: GO:0060803
name: BMP signaling pathway involved in mesodermal cell fate specification
namespace: biological_process
def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to a cell becoming specified to adopt a mesodermal fate." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "BMP signalling pathway involved in mesodermal cell fate specification" EXACT [GOC:mah]
is_a: GO:0030509 ! BMP signaling pathway
is_a: GO:0060796 ! regulation of transcription involved in primary germ layer cell fate commitment
intersection_of: GO:0030509 ! BMP signaling pathway
intersection_of: part_of GO:0007501 ! mesodermal cell fate specification
relationship: part_of GO:0007501 ! mesodermal cell fate specification
created_by: dph
creation_date: 2009-08-06T01:47:39Z

[Term]
id: GO:0060804
name: positive regulation of Wnt signaling pathway by BMP signaling pathway
namespace: biological_process
def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that results in an increase in the rate, frequency or extent of a Wnt signaling pathway." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "positive regulation of WNT receptor signaling pathway by BMP signaling pathway" EXACT [GOC:bf]
synonym: "positive regulation of Wnt receptor signaling pathway by BMP signaling pathway" EXACT []
synonym: "positive regulation of WNT receptor signalling pathway by BMP signalling pathway" EXACT [GOC:mah]
synonym: "positive regulation of Wnt-activated signaling pathway by BMP signaling pathway" EXACT [GOC:signaling]
is_a: GO:0030177 ! positive regulation of Wnt signaling pathway
is_a: GO:0030509 ! BMP signaling pathway
intersection_of: GO:0030509 ! BMP signaling pathway
intersection_of: positively_regulates GO:0016055 ! Wnt signaling pathway
relationship: positively_regulates GO:0016055 ! Wnt signaling pathway
created_by: dph
creation_date: 2009-08-06T01:52:48Z

[Term]
id: GO:0060805
name: negative regulation of trophoblast cell differentiation by transcription regulation from RNA polymerase II promoter
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of transcription from an RNA polymerase II promoter ultimately resulting in a decrease in trophoblast stem cells differentiating into the more mature cells of the trophoblast." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060806 ! negative regulation of cell differentiation involved in embryonic placenta development
created_by: dph
creation_date: 2009-08-06T01:58:25Z

[Term]
id: GO:0060806
name: negative regulation of cell differentiation involved in embryonic placenta development
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of cell differentiation that contributes to the progression of the placenta over time, from its initial condition to its mature state." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0045992 ! negative regulation of embryonic development
is_a: GO:0060800 ! regulation of cell differentiation involved in embryonic placenta development
is_a: GO:2000242 ! negative regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060706 ! cell differentiation involved in embryonic placenta development
relationship: negatively_regulates GO:0060706 ! cell differentiation involved in embryonic placenta development
created_by: dph
creation_date: 2009-08-06T02:02:18Z

[Term]
id: GO:0060807
name: regulation of transcription from RNA polymerase II promoter involved in definitive endodermal cell fate specification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that ultimately results in a cell being specified to adopt a definitive endodermal cell fate." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060796 ! regulation of transcription involved in primary germ layer cell fate commitment
relationship: part_of GO:0001714 ! endodermal cell fate specification
created_by: dph
creation_date: 2009-08-06T02:14:09Z

[Term]
id: GO:0060808
name: positive regulation of mesodermal to mesenchymal transition involved in gastrulation
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where a mesodermal cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell as part of the process of gastrulation." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0010718 ! positive regulation of epithelial to mesenchymal transition
is_a: GO:2000543 ! positive regulation of gastrulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060809 ! mesodermal to mesenchymal transition involved in gastrulation
relationship: positively_regulates GO:0060809 ! mesodermal to mesenchymal transition involved in gastrulation
created_by: dph
creation_date: 2009-08-06T02:32:53Z

[Term]
id: GO:0060809
name: mesodermal to mesenchymal transition involved in gastrulation
namespace: biological_process
def: "The epithelial to mesenchymal transition process in which a mesodermal cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell as part of the process of gastrulation." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0001837 ! epithelial to mesenchymal transition
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0007369 ! gastrulation
created_by: dph
creation_date: 2009-08-06T02:42:09Z

[Term]
id: GO:0060810
name: intracellular mRNA localization involved in pattern specification process
namespace: biological_process
def: "Any process in which mRNA is transported to, or maintained in, a specific location within an oocyte that results in a pattern being established in the embryo." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "intracellular mRNA localisation involved in pattern specification process" EXACT [GOC:mah]
is_a: GO:0008298 ! intracellular mRNA localization
intersection_of: GO:0008298 ! intracellular mRNA localization
intersection_of: part_of GO:0007389 ! pattern specification process
relationship: part_of GO:0007389 ! pattern specification process
created_by: dph
creation_date: 2009-08-07T09:19:58Z

[Term]
id: GO:0060811
name: intracellular mRNA localization involved in anterior/posterior axis specification
namespace: biological_process
def: "Any process in which mRNA is transported to, or maintained in, a specific location within the oocyte and/or syncytial embryo that contributes to the specification of the anterior/posterior axis." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "intracellular mRNA localisation involved in anterior/posterior axis specification" EXACT [GOC:mah]
is_a: GO:0060810 ! intracellular mRNA localization involved in pattern specification process
intersection_of: GO:0008298 ! intracellular mRNA localization
intersection_of: part_of GO:0009948 ! anterior/posterior axis specification
relationship: part_of GO:0009948 ! anterior/posterior axis specification
created_by: dph
creation_date: 2009-08-07T09:26:22Z

[Term]
id: GO:0060812
name: orthodenticle mRNA localization
namespace: biological_process
def: "Any process in which orthodenticle mRNA is transported to and maintained in the oocyte and/or syncytial embryo as part of the process that will specify the anterior/posterior axis." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "orthodenticle mRNA localisation" EXACT [GOC:mah]
is_a: GO:0060811 ! intracellular mRNA localization involved in anterior/posterior axis specification
created_by: dph
creation_date: 2009-08-07T09:39:01Z

[Term]
id: GO:0060813
name: anterior mRNA localization involved in anterior/posterior axis specification
namespace: biological_process
def: "Any process in which a mRNA is transported to, and maintained in the anterior portion of the oocyte and/or syncytial embryo contributing to the specification of the anterior/posterior axis." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "anterior mRNA localisation involved in anterior/posterior axis specification" EXACT [GOC:mah]
is_a: GO:0060811 ! intracellular mRNA localization involved in anterior/posterior axis specification
created_by: dph
creation_date: 2009-08-07T09:51:47Z

[Term]
id: GO:0060814
name: posterior mRNA localization involved in anterior/posterior axis specification
namespace: biological_process
def: "Any process in which a mRNA is transported to and maintained in the oocyte and/or syncytial embryo contributing to the specification of the anterior/posterior axis." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "posterior mRNA localisation involved in anterior/posterior axis specification" EXACT [GOC:mah]
is_a: GO:0060811 ! intracellular mRNA localization involved in anterior/posterior axis specification
created_by: dph
creation_date: 2009-08-07T09:54:54Z

[Term]
id: GO:0060815
name: regulation of translation involved in anterior/posterior axis specification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of translation of mRNAs that contribute to the specification of the anterior/posterior axis." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0006417 ! regulation of translation
intersection_of: GO:0006417 ! regulation of translation
intersection_of: part_of GO:0009948 ! anterior/posterior axis specification
relationship: part_of GO:0009948 ! anterior/posterior axis specification
created_by: dph
creation_date: 2009-08-07T10:02:31Z

[Term]
id: GO:0060816
name: random inactivation of X chromosome
namespace: biological_process
def: "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on either the paternal or maternal X-chromosome in the XX sex." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0009048 ! dosage compensation by inactivation of X chromosome
created_by: dph
creation_date: 2009-08-11T10:47:30Z

[Term]
id: GO:0060817
name: inactivation of paternal X chromosome
namespace: biological_process
def: "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes specifically on the paternal X-chromosome in the XX sex." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0009048 ! dosage compensation by inactivation of X chromosome
created_by: dph
creation_date: 2009-08-11T10:50:20Z

[Term]
id: GO:0060818
name: inactivation of paternal X chromosome by genetic imprinting
namespace: biological_process
def: "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on the paternal X-chromosome in the XX sex by genetic imprinting." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060817 ! inactivation of paternal X chromosome
is_a: GO:0060819 ! inactivation of X chromosome by genetic imprinting
created_by: dph
creation_date: 2009-08-11T10:52:31Z

[Term]
id: GO:0060819
name: inactivation of X chromosome by genetic imprinting
namespace: biological_process
def: "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex by genetic imprinting." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0006349 ! regulation of gene expression by genetic imprinting
is_a: GO:0009048 ! dosage compensation by inactivation of X chromosome
created_by: dph
creation_date: 2009-08-11T10:56:06Z

[Term]
id: GO:0060820
name: inactivation of X chromosome by heterochromatin assembly
namespace: biological_process
def: "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex by the mechanism of heterochromatin formation." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "inactivation of X chromosome by heterochromatin formation" EXACT []
is_a: GO:0009048 ! dosage compensation by inactivation of X chromosome
is_a: GO:0031507 ! heterochromatin assembly
created_by: dph
creation_date: 2009-08-11T10:58:06Z

[Term]
id: GO:0060821
name: inactivation of X chromosome by DNA methylation
namespace: biological_process
def: "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex by a mechanism of DNA methylation." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0009048 ! dosage compensation by inactivation of X chromosome
created_by: dph
creation_date: 2009-08-11T11:02:19Z

[Term]
id: GO:0060822
name: transforming growth factor beta receptor signaling pathway involved in axial mesodermal cell fate specification
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands and ultimately resulting in the specification of an axial mesodermal fate." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "transforming growth factor beta receptor signalling pathway involved in axial mesodermal cell fate specification" EXACT [GOC:mah]
is_a: GO:0060798 ! transforming growth factor beta receptor signaling pathway involved in mesodermal cell fate specification
intersection_of: GO:0007179 ! transforming growth factor beta receptor signaling pathway
intersection_of: part_of GO:0048327 ! axial mesodermal cell fate specification
relationship: part_of GO:0048327 ! axial mesodermal cell fate specification
created_by: dph
creation_date: 2009-08-11T12:55:33Z

[Term]
id: GO:0060823
name: canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to the formation of the neural plate anterior/posterior pattern." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation" EXACT []
synonym: "canonical Wnt receptor signalling pathway involved in neural plate anterior/posterior pattern formation" EXACT [GOC:mah]
synonym: "canonical Wnt-activated signaling pathway involved in neural plate anterior/posterior pattern formation" EXACT [GOC:signaling]
synonym: "Wnt receptor signaling pathway through beta-catenin involved in neural plate anterior/posterior pattern formation" EXACT [GOC:mtg_signal]
is_a: GO:0060070 ! canonical Wnt signaling pathway
intersection_of: GO:0060070 ! canonical Wnt signaling pathway
intersection_of: part_of GO:0021999 ! neural plate anterior/posterior regionalization
relationship: part_of GO:0021999 ! neural plate anterior/posterior regionalization
created_by: dph
creation_date: 2009-08-11T01:22:42Z

[Term]
id: GO:0060824
name: retinoic acid receptor signaling pathway involved in neural plate anterior/posterior pattern formation
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that contributes to the formation of the anterior/posterior pattern of the neural plate." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "retinoic acid receptor signalling pathway involved in neural plate anterior/posterior pattern formation" EXACT [GOC:mah]
is_a: GO:0048384 ! retinoic acid receptor signaling pathway
intersection_of: GO:0048384 ! retinoic acid receptor signaling pathway
intersection_of: part_of GO:0021999 ! neural plate anterior/posterior regionalization
relationship: part_of GO:0021999 ! neural plate anterior/posterior regionalization
created_by: dph
creation_date: 2009-08-11T01:30:57Z

[Term]
id: GO:0060825
name: fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands contributing to the anterior/posterior pattern of the neural plate." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "fibroblast growth factor receptor signalling pathway involved in neural plate anterior/posterior pattern formation" EXACT [GOC:mah]
is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway
intersection_of: GO:0008543 ! fibroblast growth factor receptor signaling pathway
intersection_of: part_of GO:0021999 ! neural plate anterior/posterior regionalization
relationship: part_of GO:0021999 ! neural plate anterior/posterior regionalization
created_by: dph
creation_date: 2009-08-11T01:40:03Z

[Term]
id: GO:0060826
name: transforming growth factor beta receptor signaling pathway involved in neural plate anterior/posterior pattern formation
namespace: biological_process
def: "A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, which contributes to the formation of the neural plate anterior/posterior pattern." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "transforming growth factor beta receptor signalling pathway involved in neural plate anterior/posterior pattern formation" EXACT [GOC:mah]
is_a: GO:0007179 ! transforming growth factor beta receptor signaling pathway
intersection_of: GO:0007179 ! transforming growth factor beta receptor signaling pathway
intersection_of: part_of GO:0021999 ! neural plate anterior/posterior regionalization
relationship: part_of GO:0021999 ! neural plate anterior/posterior regionalization
created_by: dph
creation_date: 2009-08-11T01:43:29Z

[Term]
id: GO:0060827
name: regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of Wnt signaling through beta-catenin that results in the formation of the neural plate anterior/posterior pattern." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "regulation of canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation" EXACT []
synonym: "regulation of canonical Wnt receptor signalling pathway involved in neural plate anterior/posterior pattern formation" EXACT [GOC:mah]
synonym: "regulation of canonical Wnt-activated signaling pathway involved in neural plate anterior/posterior pattern formation" EXACT [GOC:signaling]
synonym: "regulation of Wnt receptor signaling pathway through beta-catenin involved in neural plate anterior/posterior pattern formation" EXACT [GOC:mtg_signal]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0045995 ! regulation of embryonic development
is_a: GO:0060828 ! regulation of canonical Wnt signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060823 ! canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation
relationship: regulates GO:0060823 ! canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation
created_by: dph
creation_date: 2009-08-11T01:48:52Z

[Term]
id: GO:0060828
name: regulation of canonical Wnt signaling pathway
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "regulation of canonical Wnt receptor signaling pathway" EXACT []
synonym: "regulation of canonical Wnt receptor signalling pathway" EXACT [GOC:mah]
synonym: "regulation of canonical Wnt-activated signaling pathway" EXACT [GOC:signaling]
synonym: "regulation of Wnt receptor signaling pathway through beta-catenin" EXACT [GOC:mtg_signal]
is_a: GO:0030111 ! regulation of Wnt signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060070 ! canonical Wnt signaling pathway
relationship: regulates GO:0060070 ! canonical Wnt signaling pathway
created_by: dph
creation_date: 2009-08-11T01:54:47Z

[Term]
id: GO:0060829
name: negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin in the anterior end of the neural plate. This regulation sets up a Wnt signaling gradient along the anterior/posterior axis." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "negative regulation of canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern" EXACT []
synonym: "negative regulation of canonical Wnt receptor signalling pathway involved in neural plate anterior/posterior pattern formation" EXACT [GOC:mah]
synonym: "negative regulation of canonical Wnt-activated signaling pathway involved in neural plate anterior/posterior pattern" EXACT [GOC:signaling]
synonym: "negative regulation of Wnt receptor signaling pathway through beta-catenin involved in neural plate anterior/posterior pattern formation" EXACT [GOC:mtg_signal]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0060827 ! regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation
is_a: GO:0090090 ! negative regulation of canonical Wnt signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060823 ! canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation
relationship: negatively_regulates GO:0060823 ! canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation
created_by: dph
creation_date: 2009-08-11T01:58:33Z

[Term]
id: GO:0060830
name: ciliary receptor clustering involved in smoothened signaling pathway
namespace: biological_process
def: "Grouping of smoothened or patched receptors in a cilium, contributing to the smoothened signaling pathway." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "ciliary receptor clustering involved in hedgehog signaling pathway" EXACT [GOC:bf, GOC:ecd]
synonym: "ciliary receptor clustering involved in hh signaling pathway" EXACT [GOC:bf, GOC:ecd]
synonym: "ciliary receptor clustering involved in smoothened signalling pathway" EXACT [GOC:mah]
is_a: GO:0043113 ! receptor clustering
relationship: part_of GO:0007224 ! smoothened signaling pathway
created_by: dph
creation_date: 2009-08-11T02:06:33Z

[Term]
id: GO:0060831
name: smoothened signaling pathway involved in dorsal/ventral neural tube patterning
namespace: biological_process
def: "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened contributing to the dorsal/ventral pattern of the neural tube." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "hedgehog signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:bf, GOC:ecd]
synonym: "hh signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:bf, GOC:ecd]
synonym: "smoothened signalling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:mah]
is_a: GO:0007224 ! smoothened signaling pathway
intersection_of: GO:0007224 ! smoothened signaling pathway
intersection_of: part_of GO:0021904 ! dorsal/ventral neural tube patterning
relationship: part_of GO:0021904 ! dorsal/ventral neural tube patterning
created_by: dph
creation_date: 2009-08-11T02:12:58Z

[Term]
id: GO:0060832
name: oocyte animal/vegetal axis specification
namespace: biological_process
def: "The establishment, maintenance and elaboration of the animal/vegetal axis in the oocyte. The animal/vegetal axis of an oocyte is defined by the placement of the nucleus in the oocyte and can sometimes be identified by the asymmetric placement of other substances such as yolk in the oocyte. The pole of the egg that is closest to the nucleus defines the animal end, with the axis passing through the nucleus." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0007309 ! oocyte axis specification
created_by: dph
creation_date: 2009-08-11T03:11:06Z

[Term]
id: GO:0060833
name: Wnt signaling pathway involved in animal/vegetal axis specification
namespace: biological_process
def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell contributing to the specification of the animal/vegetal axis of an oocyte." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "Wnt receptor signaling pathway involved in animal/vegetal axis specification" EXACT []
synonym: "Wnt receptor signalling pathway involved in animal/vegetal axis specification" EXACT [GOC:mah]
synonym: "Wnt- activated signaling pathway involved in animal/vegetal axis specification" EXACT [GOC:signaling]
is_a: GO:0016055 ! Wnt signaling pathway
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
relationship: part_of GO:0060832 ! oocyte animal/vegetal axis specification
created_by: dph
creation_date: 2009-08-11T03:20:39Z

[Term]
id: GO:0060834
name: oral/aboral axis specification
namespace: biological_process
def: "The establishment, maintenance and elaboration of a line that delineates the mouth and the anus of an embryo." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "oral/aboral axis determination" RELATED [GOC:dph]
is_a: GO:0000578 ! embryonic axis specification
created_by: dph
creation_date: 2009-08-11T03:25:26Z

[Term]
id: GO:0060835
name: transforming growth factor receptor beta signaling pathway involved in oral/aboral axis specification
namespace: biological_process
def: "A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, which contributes to the specification of the oral/aboral axis." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "transforming growth factor receptor beta signalling pathway involved in oral/aboral axis specification" EXACT [GOC:mah]
is_a: GO:0007179 ! transforming growth factor beta receptor signaling pathway
intersection_of: GO:0007179 ! transforming growth factor beta receptor signaling pathway
intersection_of: part_of GO:0060834 ! oral/aboral axis specification
relationship: part_of GO:0060834 ! oral/aboral axis specification
created_by: dph
creation_date: 2009-08-11T03:30:40Z

[Term]
id: GO:0060836
name: lymphatic endothelial cell differentiation
namespace: biological_process
def: "The process in which a venous blood vessel endothelial cell acquires specialized features of a lymphatic vessel endothelial cell, a thin flattened cell that lines the inside surfaces of lymph vessels." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0045446 ! endothelial cell differentiation
relationship: part_of GO:0001945 ! lymph vessel development
created_by: dph
creation_date: 2009-08-11T03:45:20Z

[Term]
id: GO:0060837
name: blood vessel endothelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell, a thin flattened cell that lines the inside surfaces of blood vessels." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0045446 ! endothelial cell differentiation
relationship: part_of GO:0001568 ! blood vessel development
created_by: dph
creation_date: 2009-08-11T03:47:36Z

[Term]
id: GO:0060838
name: lymphatic endothelial cell fate commitment
namespace: biological_process
def: "The commitment of a venous blood vessel endothelial cell to a lymphatic endothelial cell fate and its capacity to differentiate into a lymphatic endothelial cell." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060839 ! endothelial cell fate commitment
relationship: part_of GO:0060836 ! lymphatic endothelial cell differentiation
created_by: dph
creation_date: 2009-08-11T03:51:45Z

[Term]
id: GO:0060839
name: endothelial cell fate commitment
namespace: biological_process
def: "The commitment of a cell to an endothelial cell fate and its capacity to differentiate into an endothelial cell." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0072148 ! epithelial cell fate commitment
relationship: part_of GO:0045446 ! endothelial cell differentiation
created_by: dph
creation_date: 2009-08-11T03:52:53Z

[Term]
id: GO:0060840
name: artery development
namespace: biological_process
def: "The progression of the artery over time, from its initial formation to the mature structure. An artery is a blood vessel that carries blood away from the heart to a capillary bed." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0001568 ! blood vessel development
created_by: dph
creation_date: 2009-08-12T10:10:51Z

[Term]
id: GO:0060841
name: venous blood vessel development
namespace: biological_process
def: "The progression of the venous blood vessel over time from its initial formation to the mature structure. Venous blood vessels carry blood back to the heart after the capillary bed." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0001568 ! blood vessel development
created_by: dph
creation_date: 2009-08-12T10:14:07Z

[Term]
id: GO:0060842
name: arterial endothelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized endothelial cell acquires specialized features of an arterial endothelial cell, a thin flattened cell that lines the inside surfaces of arteries." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060837 ! blood vessel endothelial cell differentiation
created_by: dph
creation_date: 2009-08-12T10:41:34Z

[Term]
id: GO:0060843
name: venous endothelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized endothelial cell acquires specialized features of a venous endothelial cell, a thin flattened cell that lines the inside surfaces of veins." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060837 ! blood vessel endothelial cell differentiation
created_by: dph
creation_date: 2009-08-12T10:43:40Z

[Term]
id: GO:0060844
name: arterial endothelial cell fate commitment
namespace: biological_process
def: "The commitment of a cell to an arterial endothelial cell fate and its capacity to differentiate into an arterial endothelial cell." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060846 ! blood vessel endothelial cell fate commitment
relationship: part_of GO:0060842 ! arterial endothelial cell differentiation
created_by: dph
creation_date: 2009-08-12T10:49:00Z

[Term]
id: GO:0060845
name: venous endothelial cell fate commitment
namespace: biological_process
def: "The commitment of a cell to a venous endothelial cell fate and its capacity to differentiate into an venous endothelial cell." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060846 ! blood vessel endothelial cell fate commitment
relationship: part_of GO:0060843 ! venous endothelial cell differentiation
created_by: dph
creation_date: 2009-08-12T10:51:23Z

[Term]
id: GO:0060846
name: blood vessel endothelial cell fate commitment
namespace: biological_process
def: "The commitment of a cell to a blood vessel endothelial cell fate and its capacity to differentiate into a blood vessel endothelial cell." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060839 ! endothelial cell fate commitment
relationship: part_of GO:0060837 ! blood vessel endothelial cell differentiation
created_by: dph
creation_date: 2009-08-12T10:56:14Z

[Term]
id: GO:0060847
name: endothelial cell fate specification
namespace: biological_process
def: "The process involved in the specification of identity of an endothelial cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0060839 ! endothelial cell fate commitment
created_by: dph
creation_date: 2009-08-12T11:00:04Z

[Term]
id: GO:0060848
name: endothelial cell fate determination
namespace: biological_process
def: "A process involved in cell fate commitment of an endothelial cell. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0060839 ! endothelial cell fate commitment
created_by: dph
creation_date: 2009-08-12T11:11:14Z

[Term]
id: GO:0060849
name: regulation of transcription involved in lymphatic endothelial cell fate commitment
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a venous endothelial cell to a lymphatic endothelial cell." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060850 ! regulation of transcription involved in cell fate commitment
intersection_of: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
intersection_of: part_of GO:0060838 ! lymphatic endothelial cell fate commitment
relationship: part_of GO:0060838 ! lymphatic endothelial cell fate commitment
created_by: dph
creation_date: 2009-08-12T11:19:14Z

[Term]
id: GO:0060850
name: regulation of transcription involved in cell fate commitment
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a cell to a specific fate." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
intersection_of: part_of GO:0045165 ! cell fate commitment
relationship: part_of GO:0045165 ! cell fate commitment
created_by: dph
creation_date: 2009-08-12T11:40:09Z

[Term]
id: GO:0060851
name: vascular endothelial growth factor receptor signaling pathway involved in lymphatic endothelial cell fate commitment
namespace: biological_process
def: "The series of molecular signals generated as a consequence of vascular endothelial growth factor receptor binding to one of its physiological ligands that contributes to the commitment of a venous endothelial cell to a lymphatic endothelial cell fate." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "vascular endothelial growth factor receptor signalling pathway involved in lymphatic endothelial cell fate commitment" EXACT [GOC:mah]
is_a: GO:0048010 ! vascular endothelial growth factor receptor signaling pathway
intersection_of: GO:0048010 ! vascular endothelial growth factor receptor signaling pathway
intersection_of: part_of GO:0060838 ! lymphatic endothelial cell fate commitment
relationship: part_of GO:0060838 ! lymphatic endothelial cell fate commitment
created_by: dph
creation_date: 2009-08-12T11:45:19Z

[Term]
id: GO:0060852
name: regulation of transcription involved in venous endothelial cell fate commitment
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a cell to a specific fate and contributes to a cell adopting a venous endothelial cell fate." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060850 ! regulation of transcription involved in cell fate commitment
intersection_of: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
intersection_of: part_of GO:0060845 ! venous endothelial cell fate commitment
relationship: part_of GO:0060845 ! venous endothelial cell fate commitment
created_by: dph
creation_date: 2009-08-12T11:49:49Z

[Term]
id: GO:0060853
name: Notch signaling pathway involved in arterial endothelial cell fate commitment
namespace: biological_process
def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell and contributing to the commitment of a cell to an arterial endothelial cell fate." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "Notch signalling pathway involved in arterial endothelial cell fate commitment" EXACT [GOC:mah]
is_a: GO:0007219 ! Notch signaling pathway
intersection_of: GO:0007219 ! Notch signaling pathway
intersection_of: part_of GO:0060844 ! arterial endothelial cell fate commitment
relationship: part_of GO:0060844 ! arterial endothelial cell fate commitment
created_by: dph
creation_date: 2009-08-12T11:54:49Z

[Term]
id: GO:0060854
name: patterning of lymph vessels
namespace: biological_process
def: "The process that regulates the coordinated growth and sprouting of lymph vessels giving rise to the organized lymphatic system." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0007389 ! pattern specification process
relationship: part_of GO:0001946 ! lymphangiogenesis
created_by: dph
creation_date: 2009-08-12T12:00:48Z

[Term]
id: GO:0060855
name: venous endothelial cell migration involved in lymph vessel development
namespace: biological_process
def: "The orderly movement of venous endothelial cells out of the veins giving rise to the precursors of lymphatic endothelial cells." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0043534 ! blood vessel endothelial cell migration
relationship: part_of GO:0001945 ! lymph vessel development
created_by: dph
creation_date: 2009-08-12T12:07:27Z

[Term]
id: GO:0060856
name: establishment of blood-brain barrier
namespace: biological_process
def: "Establishment of the barrier between the blood and the brain. The cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier." [GOC:dph, GOC:sart]
synonym: "establishment of BBB" EXACT [PMID:20080302]
is_a: GO:0048468 ! cell development
created_by: dph
creation_date: 2009-08-12T12:12:59Z

[Term]
id: GO:0060857
name: establishment of glial blood-brain barrier
namespace: biological_process
def: "Establishment of the glial barrier between the blood and the brain. The glial cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier." [GOC:dph, GOC:sart]
synonym: "establishment of glial BBB" EXACT [PMID:20080302]
is_a: GO:0021782 ! glial cell development
is_a: GO:0060856 ! establishment of blood-brain barrier
created_by: dph
creation_date: 2009-08-12T12:17:51Z

[Term]
id: GO:0060858
name: vesicle-mediated transport involved in floral organ abscission
namespace: biological_process
def: "The directed movement of substances within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane which are then targeted to, and fuse with, an acceptor membrane contributing to the shedding of a floral organ." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "membrane trafficking involved in floral organ shedding" RELATED [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0016192 ! vesicle-mediated transport
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0044765 ! single-organism transport
intersection_of: GO:0016192 ! vesicle-mediated transport
intersection_of: part_of GO:0010227 ! floral organ abscission
relationship: part_of GO:0010227 ! floral organ abscission
created_by: dph
creation_date: 2009-08-12T03:48:54Z

[Term]
id: GO:0060859
name: regulation of vesicle-mediated transport involved in floral organ abscission
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the directed movement of substances within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane which are then targeted to, and fuse with, an acceptor membrane contributing to the shedding of a floral organ." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060627 ! regulation of vesicle-mediated transport
is_a: GO:0060860 ! regulation of floral organ abscission
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060858 ! vesicle-mediated transport involved in floral organ abscission
relationship: regulates GO:0060858 ! vesicle-mediated transport involved in floral organ abscission
created_by: dph
creation_date: 2009-08-12T03:56:21Z

[Term]
id: GO:0060860
name: regulation of floral organ abscission
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of floral organ abscission, the controlled shedding of floral organs." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0009909 ! regulation of flower development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010227 ! floral organ abscission
relationship: regulates GO:0010227 ! floral organ abscission
created_by: dph
creation_date: 2009-08-12T03:59:45Z

[Term]
id: GO:0060861
name: positive regulation of floral organ abscission
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of floral organ shedding, the controlled shedding of floral organs." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0009911 ! positive regulation of flower development
is_a: GO:0060860 ! regulation of floral organ abscission
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010227 ! floral organ abscission
relationship: positively_regulates GO:0010227 ! floral organ abscission
created_by: dph
creation_date: 2009-08-12T04:03:09Z

[Term]
id: GO:0060862
name: negative regulation of floral organ abscission
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of floral organ abscission, the controlled shedding of floral organs." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0009910 ! negative regulation of flower development
is_a: GO:0060860 ! regulation of floral organ abscission
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010227 ! floral organ abscission
relationship: negatively_regulates GO:0010227 ! floral organ abscission
created_by: dph
creation_date: 2009-08-12T04:05:23Z

[Term]
id: GO:0060863
name: regulation of floral organ abscission by signal transduction
namespace: biological_process
def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately modulating the rate, or extent of floral organ abscission." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0007165 ! signal transduction
is_a: GO:0060860 ! regulation of floral organ abscission
intersection_of: GO:0007165 ! signal transduction
intersection_of: regulates GO:0010227 ! floral organ abscission
relationship: regulates GO:0010227 ! floral organ abscission
created_by: dph
creation_date: 2009-08-12T04:07:41Z

[Term]
id: GO:0060864
name: positive regulation of floral organ abscission by small GTPase mediated signal transduction
namespace: biological_process
def: "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals that increases the rate or extent of floral organ abscission." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0007264 ! small GTPase mediated signal transduction
is_a: GO:0060861 ! positive regulation of floral organ abscission
is_a: GO:0060863 ! regulation of floral organ abscission by signal transduction
intersection_of: GO:0007264 ! small GTPase mediated signal transduction
intersection_of: positively_regulates GO:0010227 ! floral organ abscission
relationship: positively_regulates GO:0010227 ! floral organ abscission
created_by: dph
creation_date: 2009-08-12T04:34:56Z

[Term]
id: GO:0060865
name: negative regulation of floral organ abscission by transmembrane receptor protein serine/threonine kinase signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand and contributing to the decrease in the rate or frequency of floral organ abscission." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "negative regulation of floral organ abscission by transmembrane receptor protein serine/threonine kinase signalling pathway" EXACT [GOC:mah]
is_a: GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway
is_a: GO:0060862 ! negative regulation of floral organ abscission
is_a: GO:0060863 ! regulation of floral organ abscission by signal transduction
intersection_of: GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway
intersection_of: negatively_regulates GO:0010227 ! floral organ abscission
relationship: negatively_regulates GO:0010227 ! floral organ abscission
created_by: dph
creation_date: 2009-08-12T04:42:14Z

[Term]
id: GO:0060866
name: leaf abscission
namespace: biological_process
def: "The controlled shedding of a leaf." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0009838 ! abscission
created_by: dph
creation_date: 2009-08-12T06:33:55Z

[Term]
id: GO:0060867
name: fruit abscission
namespace: biological_process
def: "The controlled shedding of a fruit." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0009838 ! abscission
created_by: dph
creation_date: 2009-08-12T06:35:28Z

[Term]
id: GO:0060868
name: regulation of vesicle-mediated transport involved in floral organ abscission by small GTPase mediated signal transduction
namespace: biological_process
def: "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals that modulates the rate or extent of floral organ abscission." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0007264 ! small GTPase mediated signal transduction
is_a: GO:0060859 ! regulation of vesicle-mediated transport involved in floral organ abscission
is_a: GO:0060863 ! regulation of floral organ abscission by signal transduction
intersection_of: GO:0007264 ! small GTPase mediated signal transduction
intersection_of: regulates GO:0060858 ! vesicle-mediated transport involved in floral organ abscission
relationship: regulates GO:0060858 ! vesicle-mediated transport involved in floral organ abscission
created_by: dph
creation_date: 2009-08-12T06:52:13Z

[Term]
id: GO:0060869
name: transmembrane receptor protein serine/threonine kinase signaling pathway involved in floral organ abscission
namespace: biological_process
def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses serine/threonine kinase activity, which contributes to the process of floral organ abscission." [GOC:dph, GOC:sdb_2009, GOC:signaling, GOC:tb]
synonym: "transmembrane receptor protein serine/threonine kinase signalling pathway involved in floral organ abscission" EXACT [GOC:mah]
is_a: GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway
is_a: GO:0022414 ! reproductive process
intersection_of: GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway
intersection_of: part_of GO:0010227 ! floral organ abscission
relationship: part_of GO:0010227 ! floral organ abscission
created_by: dph
creation_date: 2009-08-12T07:02:07Z

[Term]
id: GO:0060870
name: cell wall disassembly involved in floral organ abscission
namespace: biological_process
def: "A cellular process that results in the breakdown of the cell wall that contributes to the process of floral organ abscission." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0009830 ! cell wall modification involved in abscission
is_a: GO:0044702 ! single organism reproductive process
intersection_of: GO:0044277 ! cell wall disassembly
intersection_of: part_of GO:0010227 ! floral organ abscission
relationship: part_of GO:0010227 ! floral organ abscission
created_by: dph
creation_date: 2009-08-12T07:15:36Z

[Term]
id: GO:0060872
name: semicircular canal development
namespace: biological_process
def: "The progression of the semicircular canal from its initial formation to the mature structure." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0035295 ! tube development
relationship: part_of GO:0048839 ! inner ear development
created_by: dph
creation_date: 2009-08-13T09:36:37Z

[Term]
id: GO:0060873
name: anterior semicircular canal development
namespace: biological_process
def: "The progession of the anterior semicircular canal from its initial formation to the mature structure." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060872 ! semicircular canal development
created_by: dph
creation_date: 2009-08-13T09:39:49Z

[Term]
id: GO:0060874
name: posterior semicircular canal development
namespace: biological_process
def: "The progession of the posterior semicircular canal from its initial formation to the mature structure." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060872 ! semicircular canal development
created_by: dph
creation_date: 2009-08-13T09:42:39Z

[Term]
id: GO:0060875
name: lateral semicircular canal development
namespace: biological_process
def: "The progession of the lateral semicircular canal from its initial formation to the mature structure." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060872 ! semicircular canal development
created_by: dph
creation_date: 2009-08-13T09:43:25Z

[Term]
id: GO:0060876
name: semicircular canal formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the semicircular canal from the otic vesicle. This process begins with the regionalization of the vesicle that specifies the area where the vesicles will form and continues through the process of fusion which forms the initial tubes." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0035148 ! tube formation
relationship: part_of GO:0048752 ! semicircular canal morphogenesis
created_by: dph
creation_date: 2009-08-13T09:45:07Z

[Term]
id: GO:0060877
name: regionalization involved in semicircular canal formation
namespace: biological_process
def: "The pattern specification process that results in the subdivision of the otic epithelium in space to define an area or volume in which cells will differentiate to give rise to the semicircular canals." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0003002 ! regionalization
intersection_of: GO:0003002 ! regionalization
intersection_of: part_of GO:0060876 ! semicircular canal formation
relationship: part_of GO:0060876 ! semicircular canal formation
created_by: dph
creation_date: 2009-08-13T09:56:45Z

[Term]
id: GO:0060878
name: pouch outgrowth involved in semicircular canal formation
namespace: biological_process
def: "The morphogenetic process in which an epithelial sheet bends along a linear axis and gives rise to a pouch that will form a semicircular canal." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0060571 ! morphogenesis of an epithelial fold
intersection_of: GO:0060571 ! morphogenesis of an epithelial fold
intersection_of: part_of GO:0060876 ! semicircular canal formation
relationship: part_of GO:0060876 ! semicircular canal formation
created_by: dph
creation_date: 2009-08-13T10:01:01Z

[Term]
id: GO:0060879
name: semicircular canal fusion
namespace: biological_process
def: "Creation of the central hole of the semicircular canal by sealing the edges of the pouch that forms ruing the process of semicircular canal formation." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060606 ! tube closure
relationship: part_of GO:0060876 ! semicircular canal formation
created_by: dph
creation_date: 2009-08-13T10:05:51Z

[Term]
id: GO:0060880
name: cell morphogenesis involved in semicircular canal fusion
namespace: biological_process
def: "The change in form (cell shape and size) that occurs when a semicircular canal epithelial cell acquires the structural features that allow it to contribute to the process of semicircular canal fusion." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0000904 ! cell morphogenesis involved in differentiation
is_a: GO:0048598 ! embryonic morphogenesis
intersection_of: GO:0000902 ! cell morphogenesis
intersection_of: part_of GO:0060879 ! semicircular canal fusion
relationship: part_of GO:0060879 ! semicircular canal fusion
created_by: dph
creation_date: 2009-08-13T10:13:25Z

[Term]
id: GO:0060881
name: basal lamina disassembly
namespace: biological_process
def: "A process that results in the breakdown of the basal lamina." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0022617 ! extracellular matrix disassembly
created_by: dph
creation_date: 2009-08-13T11:27:24Z

[Term]
id: GO:0060882
name: basal lamina disassembly involved in semicircular canal fusion
namespace: biological_process
def: "A process that results in the breakdown of the basal lamina that contributes to the process of semicircular canal fusion." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060881 ! basal lamina disassembly
intersection_of: GO:0060881 ! basal lamina disassembly
intersection_of: part_of GO:0060879 ! semicircular canal fusion
relationship: part_of GO:0060879 ! semicircular canal fusion
created_by: dph
creation_date: 2009-08-13T11:29:52Z

[Term]
id: GO:0060883
name: regulation of basal lamina disassembly involved in semicircular canal fusion by cell communication
namespace: biological_process
def: "Any process that mediates interactions between a cell and its surroundings that modulates of the rate, frequency or extent of basal lamina disassembly involved in semicircular canal fusion." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0007154 ! cell communication
is_a: GO:0010715 ! regulation of extracellular matrix disassembly
is_a: GO:0045995 ! regulation of embryonic development
is_a: GO:2000027 ! regulation of organ morphogenesis
relationship: regulates GO:0060882 ! basal lamina disassembly involved in semicircular canal fusion
created_by: dph
creation_date: 2009-08-13T11:31:56Z

[Term]
id: GO:0060884
name: clearance of cells from fusion plate
namespace: biological_process
def: "The morphogenetic process in which cells are removed from the inner loop of a semicircular canal." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0002009 ! morphogenesis of an epithelium
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0048752 ! semicircular canal morphogenesis
created_by: dph
creation_date: 2009-08-13T12:25:59Z

[Term]
id: GO:0060885
name: clearance of cells from fusion plate by apoptotic process
namespace: biological_process
def: "Any apoptotic process that contributes to the shaping of the semicircular canal by removing cells in the fusion plate, forming the loops of the canals." [GOC:dph, GOC:mtg_apoptosis, GOC:sdb_2009, GOC:tb]
synonym: "clearance of cells from fusion plate by apoptosis" NARROW []
is_a: GO:0060561 ! apoptotic process involved in morphogenesis
is_a: GO:0060884 ! clearance of cells from fusion plate
created_by: dph
creation_date: 2009-08-13T12:30:17Z

[Term]
id: GO:0060886
name: clearance of cells from fusion plate by epithelial to mesenchymal transition
namespace: biological_process
def: "The process of epithelial to mesenchymal transition that contributes to the shaping of the semicircular canal by effectively removing epithelial cells from the fusion plate, forming the loops of the canals." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0001837 ! epithelial to mesenchymal transition
is_a: GO:0060884 ! clearance of cells from fusion plate
created_by: dph
creation_date: 2009-08-13T12:34:19Z

[Term]
id: GO:0060887
name: limb epidermis development
namespace: biological_process
def: "The process whose specific outcome is the progression of the epidermis of the limb over time, from its formation to the mature structure. The limb epidermis is the outer epithelial layer of the limb, it is a complex stratified squamous epithelium." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0098773 ! skin epidermis development
relationship: part_of GO:0060173 ! limb development
created_by: dph
creation_date: 2009-08-13T12:39:39Z

[Term]
id: GO:0060888
name: limb epidermis stratification
namespace: biological_process
def: "The pattern specification process that results in the subdivision of the epidermis of the limb in space to define a volume in which specific patterns of basal cell, spinous cell and granular cells will differentiate giving rise to the layers of the limb epidermis." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0003002 ! regionalization
is_a: GO:0060887 ! limb epidermis development
created_by: dph
creation_date: 2009-08-13T12:45:48Z

[Term]
id: GO:0060889
name: limb basal epidermal cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a limb epidermal basal cell. A epidermal basal cell cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into more specialized cell of the limb epidermis." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0009913 ! epidermal cell differentiation
is_a: GO:0048863 ! stem cell differentiation
relationship: part_of GO:0060887 ! limb epidermis development
created_by: dph
creation_date: 2009-08-13T01:22:12Z

[Term]
id: GO:0060890
name: limb spinous cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a limb epidermal spinous cell." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0030216 ! keratinocyte differentiation
relationship: part_of GO:0060887 ! limb epidermis development
created_by: dph
creation_date: 2009-08-13T01:31:30Z

[Term]
id: GO:0060891
name: limb granular cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a limb epidermal granular cell." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0030216 ! keratinocyte differentiation
relationship: part_of GO:0060887 ! limb epidermis development
created_by: dph
creation_date: 2009-08-13T01:33:14Z

[Term]
id: GO:0060892
name: limb basal epidermal cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into an limb basal epidermal cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0009957 ! epidermal cell fate specification
is_a: GO:0060573 ! cell fate specification involved in pattern specification
relationship: part_of GO:0060888 ! limb epidermis stratification
relationship: part_of GO:0060889 ! limb basal epidermal cell differentiation
created_by: dph
creation_date: 2009-08-13T01:41:47Z

[Term]
id: GO:0060893
name: limb granular cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into an limb granular cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0009957 ! epidermal cell fate specification
is_a: GO:0060573 ! cell fate specification involved in pattern specification
relationship: part_of GO:0060888 ! limb epidermis stratification
relationship: part_of GO:0060891 ! limb granular cell differentiation
created_by: dph
creation_date: 2009-08-13T01:44:14Z

[Term]
id: GO:0060894
name: limb spinous cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a limb spinous cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0009957 ! epidermal cell fate specification
is_a: GO:0060573 ! cell fate specification involved in pattern specification
relationship: part_of GO:0060888 ! limb epidermis stratification
relationship: part_of GO:0060890 ! limb spinous cell differentiation
created_by: dph
creation_date: 2009-08-13T01:46:23Z

[Term]
id: GO:0060895
name: retinoic acid receptor signaling pathway involved in spinal cord dorsal/ventral patterning
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that contributes to the dorsal ventral patterning of the spinal cord." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "retinoic acid receptor signalling pathway involved in spinal cord dorsal/ventral patterning" EXACT [GOC:mah]
is_a: GO:0048384 ! retinoic acid receptor signaling pathway
intersection_of: GO:0048384 ! retinoic acid receptor signaling pathway
intersection_of: part_of GO:0021513 ! spinal cord dorsal/ventral patterning
relationship: part_of GO:0021513 ! spinal cord dorsal/ventral patterning
created_by: dph
creation_date: 2009-08-13T01:51:50Z

[Term]
id: GO:0060896
name: neural plate pattern specification
namespace: biological_process
def: "The developmental process that results in the creation of defined areas or spaces within the neural plate to which cells respond and eventually are instructed to differentiate." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0007389 ! pattern specification process
created_by: dph
creation_date: 2009-08-13T02:06:27Z

[Term]
id: GO:0060897
name: neural plate regionalization
namespace: biological_process
def: "The pattern specification process that results in the subdivision of an axis or axes of the neural plate in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0003002 ! regionalization
is_a: GO:0060896 ! neural plate pattern specification
created_by: dph
creation_date: 2009-08-13T02:09:04Z

[Term]
id: GO:0060898
name: eye field cell fate commitment involved in camera-type eye formation
namespace: biological_process
def: "The commitment of neurectodermal cells to cells of the eye field and their capacity to differentiate into eye field cells. Eye field cells are neurectodermal cells that will form the optic placode." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060581 ! cell fate commitment involved in pattern specification
relationship: part_of GO:0046619 ! optic placode formation involved in camera-type eye formation
relationship: part_of GO:0060897 ! neural plate regionalization
created_by: dph
creation_date: 2009-08-13T02:10:58Z

[Term]
id: GO:0060899
name: regulation of transcription involved in eye field cell fate commitment of camera-type eye
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a neurectodermal cell to a specialized neurectodermal cell that will give rise to the optic vesicle." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060850 ! regulation of transcription involved in cell fate commitment
intersection_of: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
intersection_of: part_of GO:0060898 ! eye field cell fate commitment involved in camera-type eye formation
relationship: part_of GO:0060898 ! eye field cell fate commitment involved in camera-type eye formation
created_by: dph
creation_date: 2009-08-13T02:11:48Z

[Term]
id: GO:0060900
name: embryonic camera-type eye formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a camera-type eye from unspecified neurectoderm. This process begins with the differentiation of cells that form the optic field and ends when the optic cup has attained its shape." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0048596 ! embryonic camera-type eye morphogenesis
created_by: dph
creation_date: 2009-08-13T02:26:54Z

[Term]
id: GO:0060901
name: regulation of hair cycle by canonical Wnt signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that modulates the rate, frequency or extent of the hair cycle." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "regulation of hair cycle by canonical Wnt receptor signaling pathway" EXACT []
synonym: "regulation of hair cycle by canonical Wnt receptor signalling pathway" EXACT [GOC:mah]
synonym: "regulation of hair cycle by canonical Wnt-activated signaling pathway" EXACT [GOC:signaling]
synonym: "regulation of hair cycle by Wnt receptor signaling pathway through beta-catenin" EXACT [GOC:mtg_signal]
is_a: GO:0042634 ! regulation of hair cycle
is_a: GO:0060070 ! canonical Wnt signaling pathway
intersection_of: GO:0060070 ! canonical Wnt signaling pathway
intersection_of: regulates GO:0042633 ! hair cycle
relationship: regulates GO:0042633 ! hair cycle
created_by: dph
creation_date: 2009-08-13T02:41:10Z

[Term]
id: GO:0060902
name: regulation of hair cycle by BMP signaling pathway
namespace: biological_process
def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that modulates the rate, frequency or extent of the hair cycle." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "regulation of hair cycle by BMP signalling pathway" EXACT [GOC:mah]
is_a: GO:0030509 ! BMP signaling pathway
is_a: GO:0042634 ! regulation of hair cycle
intersection_of: GO:0030509 ! BMP signaling pathway
intersection_of: regulates GO:0042633 ! hair cycle
relationship: regulates GO:0042633 ! hair cycle
created_by: dph
creation_date: 2009-08-13T02:45:12Z

[Term]
id: GO:0060903
name: positive regulation of meiosis I
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of meiosis I, a cell cycle process comprising the steps by which a cell progresses through the first phase of meiosis, in which cells divide and homologous chromosomes are paired and segregated from each other, producing two daughter cells." [GOC:dph, GOC:tb]
is_a: GO:0045836 ! positive regulation of meiotic nuclear division
is_a: GO:0060631 ! regulation of meiosis I
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007127 ! meiosis I
relationship: positively_regulates GO:0007127 ! meiosis I
created_by: dph
creation_date: 2009-08-14T01:06:57Z

[Term]
id: GO:0060904
name: regulation of protein folding in endoplasmic reticulum
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation)." [GOC:dph, GOC:tb]
is_a: GO:1903332 ! regulation of protein folding
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034975 ! protein folding in endoplasmic reticulum
relationship: regulates GO:0034975 ! protein folding in endoplasmic reticulum
created_by: dph
creation_date: 2009-08-14T01:12:00Z

[Term]
id: GO:0060905
name: regulation of induction of conjugation upon nitrogen starvation
namespace: biological_process
def: "Any process that modulates the frequency of induction of conjugation upon nitrogen starvation, the process in which a cell initiates conjugation with cellular fusion upon nitrogen starvation." [GOC:dph, GOC:tb]
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0031137 ! regulation of conjugation with cellular fusion
is_a: GO:0032107 ! regulation of response to nutrient levels
is_a: GO:0080135 ! regulation of cellular response to stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031142 ! induction of conjugation upon nitrogen starvation
relationship: regulates GO:0031142 ! induction of conjugation upon nitrogen starvation
created_by: dph
creation_date: 2009-08-14T01:17:50Z

[Term]
id: GO:0060906
name: negative regulation of chromatin silencing by small RNA
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of chromatin silencing by small RNA. Chromatin silencing by small RNA is the repression of transcription by conversion of large regions of DNA into heterochromatin, directed by small RNAs sharing sequence identity to the repressed region." [GOC:dph, GOC:tb]
is_a: GO:0010964 ! regulation of chromatin silencing by small RNA
is_a: GO:0031936 ! negative regulation of chromatin silencing
is_a: GO:0060967 ! negative regulation of gene silencing by RNA
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0031048 ! chromatin silencing by small RNA
relationship: negatively_regulates GO:0031048 ! chromatin silencing by small RNA
created_by: dph
creation_date: 2009-08-14T01:22:24Z

[Term]
id: GO:0060907
name: positive regulation of macrophage cytokine production
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:dph, GOC:tb]
is_a: GO:0010935 ! regulation of macrophage cytokine production
is_a: GO:0061081 ! positive regulation of myeloid leukocyte cytokine production involved in immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010934 ! macrophage cytokine production
relationship: positively_regulates GO:0010934 ! macrophage cytokine production
created_by: dph
creation_date: 2009-09-04T02:32:18Z

[Term]
id: GO:0060908
name: plasmid copy number maintenance
namespace: biological_process
def: "The maintenance of the number of copies of extrachromosomal plasmid DNA." [GOC:dph, GOC:tb]
is_a: GO:0006276 ! plasmid maintenance
created_by: dph
creation_date: 2009-09-04T02:49:08Z

[Term]
id: GO:0060909
name: regulation of DNA replication initiation involved in plasmid copy number maintenance
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of initiation of plasmid DNA replication that contributes to copy number maintenance." [GOC:dph, GOC:tb]
is_a: GO:0030174 ! regulation of DNA-dependent DNA replication initiation
relationship: part_of GO:0060908 ! plasmid copy number maintenance
created_by: dph
creation_date: 2009-09-04T02:51:48Z

[Term]
id: GO:0060910
name: negative regulation of DNA replication initiation involved in plasmid copy number maintenance
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of initiation of plasmid DNA replication that contributes to copy number maintenance." [GOC:dph, GOC:tb]
is_a: GO:0032297 ! negative regulation of DNA-dependent DNA replication initiation
is_a: GO:0060909 ! regulation of DNA replication initiation involved in plasmid copy number maintenance
created_by: dph
creation_date: 2009-09-04T02:56:29Z

[Term]
id: GO:0060911
name: cardiac cell fate commitment
namespace: biological_process
def: "The commitment of cells to specific cardiac cell fates and their capacity to differentiate into cardiac cells. Cardiac cells are cells that comprise the organ which pumps blood through the circulatory system." [GOC:mtg_heart]
synonym: "cardiocyte cell fate commitment" EXACT [GOC:dph]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0035051 ! cardiocyte differentiation
created_by: dph
creation_date: 2009-09-17T08:47:00Z

[Term]
id: GO:0060912
name: cardiac cell fate specification
namespace: biological_process
def: "The process involved in the specification of cardiac cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment." [GOC:mtg_heart]
synonym: "cardiocyte cell fate specification" EXACT [GOC:dph]
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0060911 ! cardiac cell fate commitment
created_by: dph
creation_date: 2009-09-17T08:53:21Z

[Term]
id: GO:0060913
name: cardiac cell fate determination
namespace: biological_process
def: "The process involved in cardiac cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [GOC:mtg_heart]
synonym: "cardiocyte cell fate determination" RELATED [GOC:dph]
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0060911 ! cardiac cell fate commitment
created_by: dph
creation_date: 2009-09-17T08:55:29Z

[Term]
id: GO:0060914
name: heart formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the heart from unspecified parts. This process begins with the specific processes that contribute to the appearance of the heart field and the arrival of cardiac neural crest to the heart region. The process ends when the structural rudiment is recognizable." [GOC:mtg_heart]
synonym: "cardiogenesis" RELATED [GOC:mtg_heart]
is_a: GO:0048645 ! organ formation
relationship: part_of GO:0003007 ! heart morphogenesis
created_by: dph
creation_date: 2009-09-17T09:02:13Z

[Term]
id: GO:0060915
name: mesenchymal cell differentiation involved in lung development
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell of the lung. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types." [GOC:dph]
is_a: GO:0048762 ! mesenchymal cell differentiation
intersection_of: GO:0048762 ! mesenchymal cell differentiation
intersection_of: part_of GO:0030324 ! lung development
relationship: part_of GO:0030324 ! lung development
created_by: dph
creation_date: 2009-09-18T11:45:33Z

[Term]
id: GO:0060916
name: mesenchymal cell proliferation involved in lung development
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population that contributes to the progression of the lung over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:dph]
is_a: GO:0010463 ! mesenchymal cell proliferation
intersection_of: GO:0010463 ! mesenchymal cell proliferation
intersection_of: part_of GO:0030324 ! lung development
relationship: part_of GO:0030324 ! lung development
created_by: dph
creation_date: 2009-09-18T11:50:17Z

[Term]
id: GO:0060917
name: regulation of (1->6)-beta-D-glucan biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->6)-beta-D-glucans." [GOC:dph, GOC:tb]
synonym: "regulation of 1,6-beta-glucan biosynthetic process" EXACT []
is_a: GO:0032951 ! regulation of beta-glucan biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006078 ! (1->6)-beta-D-glucan biosynthetic process
relationship: regulates GO:0006078 ! (1->6)-beta-D-glucan biosynthetic process
created_by: dph
creation_date: 2009-09-18T02:15:01Z

[Term]
id: GO:0060918
name: auxin transport
namespace: biological_process
def: "The directed movement of auxin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb]
is_a: GO:0009914 ! hormone transport
created_by: dph
creation_date: 2009-09-28T02:44:54Z

[Term]
id: GO:0060919
name: auxin influx
namespace: biological_process
def: "The process involved in the transport of auxin into the cell." [GOC:dph, GOC:tb]
is_a: GO:0060918 ! auxin transport
created_by: dph
creation_date: 2009-09-28T02:49:18Z

[Term]
id: GO:0060920
name: cardiac pacemaker cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a pacemaker cell. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart]
synonym: "pacemaker cell differentiation" BROAD []
is_a: GO:0055007 ! cardiac muscle cell differentiation
created_by: dph
creation_date: 2009-09-29T11:01:31Z

[Term]
id: GO:0060921
name: sinoatrial node cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a sinoatrial (SA) node cell. SA node cells are pacemaker cells that are found in the sinoatrial node." [GOC:mtg_heart]
synonym: "SA node cell differentiation" EXACT [GOC:mtg_heart]
synonym: "SAN cell differentiation" EXACT [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "sinus node cell differentiation" NARROW [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0060920 ! cardiac pacemaker cell differentiation
relationship: part_of GO:0003163 ! sinoatrial node development
created_by: dph
creation_date: 2009-09-29T11:03:30Z

[Term]
id: GO:0060922
name: atrioventricular node cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an atrioventricular (AV) node cell. AV node cells are pacemaker cells that are found in the atrioventricular node." [GOC:mtg_heart]
synonym: "AV node cell differentiation" RELATED [GOC:mtg_heart]
is_a: GO:0003292 ! cardiac septum cell differentiation
is_a: GO:0060920 ! cardiac pacemaker cell differentiation
relationship: part_of GO:0003162 ! atrioventricular node development
created_by: dph
creation_date: 2009-09-29T11:07:06Z

[Term]
id: GO:0060923
name: cardiac muscle cell fate commitment
namespace: biological_process
def: "The commitment of cells to specific cardiac muscle cell fates and their capacity to differentiate into cardiac muscle cells. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction." [GOC:mtg_heart]
synonym: "cardiomyocyte cell fate commitment" EXACT [GOC:mtg_heart]
synonym: "heart muscle cell fate commitment" EXACT [GOC:mtg_heart]
is_a: GO:0042693 ! muscle cell fate commitment
is_a: GO:0060911 ! cardiac cell fate commitment
relationship: part_of GO:0055007 ! cardiac muscle cell differentiation
created_by: dph
creation_date: 2009-09-29T11:13:32Z

[Term]
id: GO:0060924
name: atrial cardiac muscle cell fate commitment
namespace: biological_process
def: "The commitment of cells to atrial cardiac muscle cell fates and their capacity to differentiate into cardiac muscle cells of the atrium. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction." [GOC:mtg_heart]
synonym: "atrial cardiomyocyte cell fate commitment" RELATED [GOC:mtg_heart]
synonym: "atrial heart muscle cell fate commitment" EXACT [GOC:mtg_heart]
is_a: GO:0060923 ! cardiac muscle cell fate commitment
relationship: part_of GO:0055011 ! atrial cardiac muscle cell differentiation
created_by: dph
creation_date: 2009-09-29T11:46:10Z

[Term]
id: GO:0060925
name: ventricular cardiac muscle cell fate commitment
namespace: biological_process
def: "The commitment of cells to ventricular cardiac muscle cell fates and their capacity to differentiate into cardiac muscle cells of the ventricle. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction." [GOC:mtg_heart]
synonym: "ventricular cardiomyocyte cell fate commitment" EXACT [GOC:mtg_heart]
synonym: "ventricular heart muscle cell fate commitment" EXACT [GOC:mtg_heart]
is_a: GO:0060923 ! cardiac muscle cell fate commitment
relationship: part_of GO:0055012 ! ventricular cardiac muscle cell differentiation
created_by: dph
creation_date: 2009-09-29T11:49:39Z

[Term]
id: GO:0060926
name: cardiac pacemaker cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a pacemaker cell over time, from its formation to the mature state. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart]
synonym: "pacemaker cell development" BROAD []
is_a: GO:0055013 ! cardiac muscle cell development
relationship: part_of GO:0060920 ! cardiac pacemaker cell differentiation
created_by: dph
creation_date: 2009-09-29T11:51:55Z

[Term]
id: GO:0060927
name: cardiac pacemaker cell fate commitment
namespace: biological_process
def: "The commitment of cells to pacemaker cell fates and their capacity to differentiate into pacemaker cells. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart]
synonym: "pacemaker cell fate commitment" BROAD []
is_a: GO:0060923 ! cardiac muscle cell fate commitment
relationship: part_of GO:0060920 ! cardiac pacemaker cell differentiation
created_by: dph
creation_date: 2009-09-29T11:54:22Z

[Term]
id: GO:0060928
name: atrioventricular node cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of an atrioventricular (AV) node cell over time, from its formation to the mature state." [GOC:mtg_heart]
synonym: "AV node cell development" EXACT [GOC:mtg_heart]
is_a: GO:0060926 ! cardiac pacemaker cell development
relationship: part_of GO:0060922 ! atrioventricular node cell differentiation
created_by: dph
creation_date: 2009-09-29T11:59:26Z

[Term]
id: GO:0060929
name: atrioventricular node cell fate commitment
namespace: biological_process
def: "The commitment of cells to atrioventricular (AV) node cell fates and their capacity to differentiate into AV node cells." [GOC:mtg_heart]
synonym: "AV node cell fate commitment" EXACT [GOC:mtg_heart]
is_a: GO:0060927 ! cardiac pacemaker cell fate commitment
relationship: part_of GO:0060922 ! atrioventricular node cell differentiation
created_by: dph
creation_date: 2009-09-29T12:01:24Z

[Term]
id: GO:0060930
name: sinoatrial node cell fate commitment
namespace: biological_process
def: "The commitment of cells to sinoatrial (SA) node cell fates and their capacity to differentiate into SA node cells. SA node cells are pacemaker cells that are found in the sinoatrial node." [GOC:mtg_heart]
synonym: "SA node cell commitment" EXACT [GOC:mtg_heart]
synonym: "SAN cell commitment" EXACT [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "sinus node cell commitment" NARROW [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0060927 ! cardiac pacemaker cell fate commitment
relationship: part_of GO:0060921 ! sinoatrial node cell differentiation
created_by: dph
creation_date: 2009-09-29T12:03:38Z

[Term]
id: GO:0060931
name: sinoatrial node cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a sinoatrial (SA) node cell over time, from its formation to the mature state. SA node cells are pacemaker cells that are found in the sinoatrial node." [GOC:mtg_heart]
synonym: "SA node cell development" EXACT [GOC:mtg_heart]
synonym: "SAN cell development" EXACT [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "sinus node cell development" NARROW [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0060926 ! cardiac pacemaker cell development
relationship: part_of GO:0060921 ! sinoatrial node cell differentiation
created_by: dph
creation_date: 2009-09-29T12:05:47Z

[Term]
id: GO:0060932
name: His-Purkinje system cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell of the His-Purkinje system. These cells form the fibers regulate cardiac muscle contraction in the ventricles." [GOC:mtg_heart]
is_a: GO:0055007 ! cardiac muscle cell differentiation
relationship: part_of GO:0003164 ! His-Purkinje system development
created_by: dph
creation_date: 2009-09-29T01:10:32Z

[Term]
id: GO:0060933
name: His-Purkinje system cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a His-Purkinje cell over time, from its formation to the mature state. These cells form the fibers that regulate cardiac muscle contraction in the ventricles." [GOC:mtg_heart]
is_a: GO:0055006 ! cardiac cell development
relationship: part_of GO:0060932 ! His-Purkinje system cell differentiation
created_by: dph
creation_date: 2009-09-29T01:15:02Z

[Term]
id: GO:0060934
name: His-Purkinje system cell fate commitment
namespace: biological_process
def: "The commitment of cells to His-Purkinje cell fates and their capacity to differentiate into His-Purkinje cells. These cells form the fibers that regulate cardiac muscle contraction in the ventricles." [GOC:mtg_heart]
is_a: GO:0060911 ! cardiac cell fate commitment
relationship: part_of GO:0060932 ! His-Purkinje system cell differentiation
created_by: dph
creation_date: 2009-09-29T01:17:00Z

[Term]
id: GO:0060935
name: cardiac fibroblast cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart]
is_a: GO:0035051 ! cardiocyte differentiation
created_by: dph
creation_date: 2009-09-29T01:20:04Z

[Term]
id: GO:0060936
name: cardiac fibroblast cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cardiac fibroblast over time, from its formation to the mature state. A cardiac fibroblast is a connective tissue cell of the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart]
is_a: GO:0055006 ! cardiac cell development
relationship: part_of GO:0060935 ! cardiac fibroblast cell differentiation
created_by: dph
creation_date: 2009-09-29T01:23:03Z

[Term]
id: GO:0060937
name: cardiac fibroblast cell fate commitment
namespace: biological_process
def: "The commitment of cells to a cardiac fibroblast fate and their capacity to differentiate into cardiac fibroblast cells. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart]
is_a: GO:0060911 ! cardiac cell fate commitment
relationship: part_of GO:0060935 ! cardiac fibroblast cell differentiation
created_by: dph
creation_date: 2009-09-29T01:24:59Z

[Term]
id: GO:0060938
name: epicardium-derived cardiac fibroblast cell differentiation
namespace: biological_process
def: "The process in which an epicardial cell acquires the specialized structural and/or functional features of a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart]
is_a: GO:0060935 ! cardiac fibroblast cell differentiation
created_by: dph
creation_date: 2009-09-29T01:28:03Z

[Term]
id: GO:0060939
name: epicardium-derived cardiac fibroblast cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of an epicardial-derived cardiac fibroblast over time, from its formation to the mature state. A epicardial-derived cardiac fibroblast is a connective tissue cell of the heart that arises from the epicardium and secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart]
is_a: GO:0060936 ! cardiac fibroblast cell development
relationship: part_of GO:0060938 ! epicardium-derived cardiac fibroblast cell differentiation
created_by: dph
creation_date: 2009-09-29T01:29:19Z

[Term]
id: GO:0060940
name: epithelial to mesenchymal transition involved in cardiac fibroblast development
namespace: biological_process
def: "A transition where an epicardial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will mature into a cardiac fibroblast." [GOC:mtg_heart]
is_a: GO:0060317 ! cardiac epithelial to mesenchymal transition
intersection_of: GO:0060317 ! cardiac epithelial to mesenchymal transition
intersection_of: part_of GO:0060939 ! epicardium-derived cardiac fibroblast cell development
relationship: part_of GO:0060939 ! epicardium-derived cardiac fibroblast cell development
created_by: dph
creation_date: 2009-09-29T01:32:36Z

[Term]
id: GO:0060941
name: epicardium-derived cardiac fibroblast cell fate commitment
namespace: biological_process
def: "The commitment of an epicardial cell to a cardiac fibroblast cell fate and its capacity to differentiate into a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart]
is_a: GO:0060937 ! cardiac fibroblast cell fate commitment
relationship: part_of GO:0060938 ! epicardium-derived cardiac fibroblast cell differentiation
created_by: dph
creation_date: 2009-09-29T01:44:36Z

[Term]
id: GO:0060942
name: neural crest-derived cardiac fibroblast cell differentiation
namespace: biological_process
def: "The process in which a neural crest cell acquires the specialized structural and/or functional features of a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart]
is_a: GO:0060935 ! cardiac fibroblast cell differentiation
created_by: dph
creation_date: 2009-09-29T01:54:19Z

[Term]
id: GO:0060943
name: neural crest-derived cardiac fibroblast cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cardiac fibroblast over time, from its formation from a neural crest cell to the mature state. A cardiac fibroblast is a connective tissue cell of the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart]
is_a: GO:0060936 ! cardiac fibroblast cell development
relationship: part_of GO:0060942 ! neural crest-derived cardiac fibroblast cell differentiation
created_by: dph
creation_date: 2009-09-29T02:31:24Z

[Term]
id: GO:0060944
name: neural crest-derived cardiac fibroblast cell fate commitment
namespace: biological_process
def: "The commitment of neural crest cells to a cardiac fibroblast fate and their capacity to differentiate into cardiac fibroblast cells. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart]
is_a: GO:0060937 ! cardiac fibroblast cell fate commitment
relationship: part_of GO:0060942 ! neural crest-derived cardiac fibroblast cell differentiation
created_by: dph
creation_date: 2009-09-29T02:42:39Z

[Term]
id: GO:0060945
name: cardiac neuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron of the heart." [GOC:mtg_heart]
synonym: "heart neuron differentiation" EXACT [GOC:mtg_heart]
is_a: GO:0030182 ! neuron differentiation
is_a: GO:0035051 ! cardiocyte differentiation
relationship: part_of GO:0048483 ! autonomic nervous system development
created_by: dph
creation_date: 2009-09-29T02:45:33Z

[Term]
id: GO:0060946
name: cardiac blood vessel endothelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell of the heart. Blood vessel endothelial cells are thin flattened cells that line the inside surfaces of blood vessels." [GOC:mtg_heart]
is_a: GO:0003348 ! cardiac endothelial cell differentiation
is_a: GO:0060837 ! blood vessel endothelial cell differentiation
created_by: dph
creation_date: 2009-09-29T02:48:55Z

[Term]
id: GO:0060947
name: cardiac vascular smooth muscle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a cardiac vascular smooth muscle cell. A cardiac vascular smooth muscle cell covers the heart vasculature and lacks transverse striations in its constituent fibers." [GOC:mtg_heart]
synonym: "heart vascular smooth muscle cell differentiation" EXACT [GOC:mtg_heart]
is_a: GO:0035051 ! cardiocyte differentiation
is_a: GO:0035886 ! vascular smooth muscle cell differentiation
relationship: part_of GO:0060976 ! coronary vasculature development
created_by: dph
creation_date: 2009-09-29T02:56:08Z

[Term]
id: GO:0060948
name: cardiac vascular smooth muscle cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cardiac vascular smooth muscle cell over time, from its formation to the mature state." [GOC:mtg_heart]
synonym: "heart vascular smooth muscle cell development" EXACT [GOC:mtg_heart]
is_a: GO:0055006 ! cardiac cell development
is_a: GO:0097084 ! vascular smooth muscle cell development
relationship: part_of GO:0060947 ! cardiac vascular smooth muscle cell differentiation
created_by: dph
creation_date: 2009-09-29T03:00:24Z

[Term]
id: GO:0060949
name: cardiac vascular smooth muscle cell fate commitment
namespace: biological_process
def: "The commitment of cells to a cardiac vascular smooth muscle cell fate and its capacity to differentiate into a cardiac vascular smooth muscle cell." [GOC:mtg_heart]
synonym: "heart vascular smooth muscle cell fate commitment" EXACT [GOC:mtg_heart]
is_a: GO:0060911 ! cardiac cell fate commitment
is_a: GO:0097081 ! vascular smooth muscle cell fate commitment
relationship: part_of GO:0060947 ! cardiac vascular smooth muscle cell differentiation
created_by: dph
creation_date: 2009-09-29T03:02:45Z

[Term]
id: GO:0060950
name: cardiac glial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a glial cell of the heart." [GOC:mtg_heart]
is_a: GO:0010001 ! glial cell differentiation
is_a: GO:0035051 ! cardiocyte differentiation
created_by: dph
creation_date: 2009-09-29T03:06:37Z

[Term]
id: GO:0060951
name: neural crest-derived cardiac glial cell differentiation
namespace: biological_process
def: "The process in which a neural crest cell acquires the specialized features of a glial cell of the heart." [GOC:mtg_heart]
is_a: GO:0060950 ! cardiac glial cell differentiation
created_by: dph
creation_date: 2009-09-29T03:08:06Z

[Term]
id: GO:0060952
name: cardiac glial cell development
namespace: biological_process
def: "The process aimed at the progression of a cardiac glial cell over time, from its formation to the fully functional mature cell." [GOC:mtg_heart]
is_a: GO:0021782 ! glial cell development
is_a: GO:0055006 ! cardiac cell development
relationship: part_of GO:0060950 ! cardiac glial cell differentiation
created_by: dph
creation_date: 2009-09-29T03:09:24Z

[Term]
id: GO:0060953
name: cardiac glial cell fate commitment
namespace: biological_process
def: "The commitment of cells to cardiac glial cell fates and their capacity to differentiate into cardiac glial cells." [GOC:mtg_heart]
is_a: GO:0021781 ! glial cell fate commitment
is_a: GO:0060911 ! cardiac cell fate commitment
relationship: part_of GO:0060950 ! cardiac glial cell differentiation
created_by: dph
creation_date: 2009-09-29T03:11:23Z

[Term]
id: GO:0060954
name: neural crest-derived cardiac glial cell development
namespace: biological_process
def: "The process aimed at the progression of a neural crest-derived cardiac glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:mtg_heart]
is_a: GO:0060952 ! cardiac glial cell development
relationship: part_of GO:0060951 ! neural crest-derived cardiac glial cell differentiation
created_by: dph
creation_date: 2009-09-29T03:14:15Z

[Term]
id: GO:0060955
name: neural crest-derived cardiac glial cell fate commitment
namespace: biological_process
def: "The commitment of neural crest cells to cardiac glial cell fates and their capacity to differentiate into cardiac glial cells." [GOC:mtg_heart]
is_a: GO:0060953 ! cardiac glial cell fate commitment
relationship: part_of GO:0060951 ! neural crest-derived cardiac glial cell differentiation
created_by: dph
creation_date: 2009-09-29T03:15:04Z

[Term]
id: GO:0060956
name: endocardial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an endocardial cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart. The endocardium is the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:mtg_heart]
is_a: GO:0003348 ! cardiac endothelial cell differentiation
relationship: part_of GO:0003157 ! endocardium development
created_by: dph
creation_date: 2009-09-29T03:20:39Z

[Term]
id: GO:0060957
name: endocardial cell fate commitment
namespace: biological_process
def: "The commitment of a cell to an endocardial cell fate and its capacity to differentiate into an endocardial cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart." [GOC:mtg_heart]
is_a: GO:0060839 ! endothelial cell fate commitment
is_a: GO:0060911 ! cardiac cell fate commitment
relationship: part_of GO:0060956 ! endocardial cell differentiation
created_by: dph
creation_date: 2009-09-29T03:24:29Z

[Term]
id: GO:0060958
name: endocardial cell development
namespace: biological_process
def: "The progression of an endocardial cell over time, from its formation to the mature cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart." [GOC:mtg_heart]
is_a: GO:0001885 ! endothelial cell development
is_a: GO:0055006 ! cardiac cell development
relationship: part_of GO:0060956 ! endocardial cell differentiation
created_by: dph
creation_date: 2009-09-29T03:26:59Z

[Term]
id: GO:0060959
name: cardiac neuron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cardiac neuron over time, from its formation to the mature state." [GOC:mtg_heart]
synonym: "heart neuron development" EXACT [GOC:mtg_heart]
is_a: GO:0048666 ! neuron development
is_a: GO:0055006 ! cardiac cell development
relationship: part_of GO:0060945 ! cardiac neuron differentiation
created_by: dph
creation_date: 2009-09-30T10:14:56Z

[Term]
id: GO:0060960
name: cardiac neuron fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron of the heart." [GOC:mtg_heart]
synonym: "heart neuron fate commitment" EXACT [GOC:mtg_heart]
is_a: GO:0048663 ! neuron fate commitment
is_a: GO:0060911 ! cardiac cell fate commitment
relationship: part_of GO:0060945 ! cardiac neuron differentiation
created_by: dph
creation_date: 2009-09-30T10:23:47Z

[Term]
id: GO:0060961
name: phospholipase D inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a phospholipase D, an enzyme that catalyzes the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate." [GOC:dph, GOC:tb]
is_a: GO:0004859 ! phospholipase inhibitor activity
relationship: negatively_regulates GO:0004630 ! phospholipase D activity
created_by: dph
creation_date: 2009-10-05T02:47:26Z

[Term]
id: GO:0060962
name: regulation of ribosomal protein gene transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes by RNA polymerase II, originating at an RNA polymerase II promoter." [GOC:dph, GOC:tb, GOC:txnOH]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
created_by: dph
creation_date: 2009-10-05T03:00:40Z

[Term]
id: GO:0060963
name: positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes by RNA polymerase II, originating at an RNA polymerase II promoter." [GOC:dph, GOC:tb, GOC:txnOH]
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
is_a: GO:0060962 ! regulation of ribosomal protein gene transcription from RNA polymerase II promoter
created_by: dph
creation_date: 2009-10-05T03:04:05Z

[Term]
id: GO:0060964
name: regulation of gene silencing by miRNA
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: mRNA cleavage or translational repression." [GOC:dph, GOC:tb]
synonym: "regulation of gene silencing by microRNA" EXACT [GOC:pr]
is_a: GO:0006417 ! regulation of translation
is_a: GO:0060147 ! regulation of posttranscriptional gene silencing
is_a: GO:0060966 ! regulation of gene silencing by RNA
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035195 ! gene silencing by miRNA
relationship: regulates GO:0035195 ! gene silencing by miRNA
created_by: dph
creation_date: 2009-10-05T03:10:28Z

[Term]
id: GO:0060965
name: negative regulation of gene silencing by miRNA
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: mRNA cleavage or translational repression." [GOC:dph, GOC:tb]
synonym: "negative regulation of gene silencing by microRNA" EXACT [GOC:bf, GOC:pr]
is_a: GO:0045727 ! positive regulation of translation
is_a: GO:0060149 ! negative regulation of posttranscriptional gene silencing
is_a: GO:0060964 ! regulation of gene silencing by miRNA
is_a: GO:0060967 ! negative regulation of gene silencing by RNA
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035195 ! gene silencing by miRNA
relationship: negatively_regulates GO:0035195 ! gene silencing by miRNA
created_by: dph
creation_date: 2009-10-05T03:14:14Z

[Term]
id: GO:0060966
name: regulation of gene silencing by RNA
namespace: biological_process
def: "Any process that regulates the rate, frequency, or extent of gene silencing by RNA. Gene silencing by RNA is the process in which RNA molecules inactivate expression of target genes." [GOC:dph, GOC:tb]
is_a: GO:0060968 ! regulation of gene silencing
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031047 ! gene silencing by RNA
relationship: regulates GO:0031047 ! gene silencing by RNA
created_by: dph
creation_date: 2009-10-05T03:17:02Z

[Term]
id: GO:0060967
name: negative regulation of gene silencing by RNA
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of gene silencing by RNA. Gene silencing by RNA is the process in which RNA molecules inactivate expression of target genes." [GOC:dph, GOC:tb]
is_a: GO:0060966 ! regulation of gene silencing by RNA
is_a: GO:0060969 ! negative regulation of gene silencing
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0031047 ! gene silencing by RNA
relationship: negatively_regulates GO:0031047 ! gene silencing by RNA
created_by: dph
creation_date: 2009-10-05T03:21:05Z

[Term]
id: GO:0060968
name: regulation of gene silencing
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of gene silencing, the transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation." [GOC:dph, GOC:tb]
is_a: GO:0010468 ! regulation of gene expression
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016458 ! gene silencing
relationship: regulates GO:0016458 ! gene silencing
created_by: dph
creation_date: 2009-10-05T03:23:56Z

[Term]
id: GO:0060969
name: negative regulation of gene silencing
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of gene silencing, the transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation." [GOC:dph, GOC:tb]
is_a: GO:0010628 ! positive regulation of gene expression
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0060968 ! regulation of gene silencing
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016458 ! gene silencing
relationship: negatively_regulates GO:0016458 ! gene silencing
created_by: dph
creation_date: 2009-10-05T03:26:19Z

[Term]
id: GO:0060970
name: embryonic heart tube dorsal/ventral pattern formation
namespace: biological_process
def: "The regionalization process in which the areas along the dorsal/ventral axis of the embryonic heart tube are established. This process will determine the patterns of cell differentiation along the axis." [GOC:mtg_heart]
is_a: GO:0009953 ! dorsal/ventral pattern formation
relationship: part_of GO:0035050 ! embryonic heart tube development
created_by: dph
creation_date: 2009-10-06T10:14:53Z

[Term]
id: GO:0060971
name: embryonic heart tube left/right pattern formation
namespace: biological_process
def: "The pattern specification process that results in the subdivision of the left/right axis of the embryonic heart tube in space to define an area or volume in which specific patterns of cell differentiation will take place." [GOC:mtg_heart]
is_a: GO:0060972 ! left/right pattern formation
relationship: part_of GO:0035050 ! embryonic heart tube development
created_by: dph
creation_date: 2009-10-06T10:22:11Z

[Term]
id: GO:0060972
name: left/right pattern formation
namespace: biological_process
def: "The pattern specification process that results in the subdivision of the left/right axis in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment." [GOC:mtg_heart]
is_a: GO:0003002 ! regionalization
created_by: dph
creation_date: 2009-10-06T10:25:58Z

[Term]
id: GO:0060973
name: cell migration involved in heart development
namespace: biological_process
def: "The orderly movement of a cell from one site to another that will contribute to the progression of the heart over time, from its initial formation, to the mature organ." [GOC:mtg_heart]
is_a: GO:0016477 ! cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: part_of GO:0007507 ! heart development
relationship: part_of GO:0007507 ! heart development
created_by: dph
creation_date: 2009-10-06T10:53:49Z

[Term]
id: GO:0060974
name: cell migration involved in heart formation
namespace: biological_process
def: "The orderly movement of a cell from one site to another that contribute to the formation of the heart. The initial heart structure is made up of mesoderm-derived heart progenitor cells and neural crest-derived cells." [GOC:mtg_heart]
is_a: GO:0060973 ! cell migration involved in heart development
intersection_of: GO:0016477 ! cell migration
intersection_of: part_of GO:0060914 ! heart formation
relationship: part_of GO:0060914 ! heart formation
created_by: dph
creation_date: 2009-10-06T10:56:33Z

[Term]
id: GO:0060975
name: cardioblast migration to the midline involved in heart field formation
namespace: biological_process
def: "The orderly movement of a cardioblast toward the midline to form the heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]
synonym: "cardiac progenitor cell midline migration" EXACT [GOC:mtg_heart]
synonym: "cardioblast midline convergence" EXACT [GOC:mtg_heart]
is_a: GO:0003260 ! cardioblast migration
is_a: GO:0003318 ! cell migration to the midline involved in heart development
relationship: part_of GO:0060029 ! convergent extension involved in organogenesis
created_by: dph
creation_date: 2009-10-06T10:59:36Z

[Term]
id: GO:0060976
name: coronary vasculature development
namespace: biological_process
def: "The process whose specific outcome is the progression of the blood vessels of the heart over time, from its formation to the mature structure." [GOC:mtg_heart]
synonym: "cardiac blood vessel development" EXACT [GOC:mtg_heart]
synonym: "cardiac vasculature development" EXACT [GOC:mtg_heart]
synonym: "coronary blood vessel development" EXACT [GOC:mtg_heart]
synonym: "heart blood vessel development" EXACT [GOC:mtg_heart]
synonym: "heart vasculature development" EXACT [GOC:mtg_heart]
is_a: GO:0001568 ! blood vessel development
relationship: part_of GO:0007507 ! heart development
created_by: dph
creation_date: 2009-10-06T12:15:23Z

[Term]
id: GO:0060977
name: coronary vasculature morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of blood vessels of the heart are generated and organized. The blood vessel is the vasculature carrying blood." [GOC:mtg_heart]
synonym: "cardiac blood vessel morphogenesis" EXACT [GOC:mtg_heart]
synonym: "cardiac vasculature morphogenesis" EXACT [GOC:mtg_heart]
synonym: "coronary blood vessel morphogenesis" EXACT [GOC:mtg_heart]
synonym: "heart blood vessel morphogenesis" EXACT [GOC:mtg_heart]
synonym: "heart vasculature morphogenesis" EXACT [GOC:mtg_heart]
is_a: GO:0048514 ! blood vessel morphogenesis
relationship: part_of GO:0060976 ! coronary vasculature development
created_by: dph
creation_date: 2009-10-06T12:28:23Z

[Term]
id: GO:0060978
name: angiogenesis involved in coronary vascular morphogenesis
namespace: biological_process
def: "Blood vessel formation in the heart when new vessels emerge from the proliferation of pre-existing blood vessels." [GOC:mtg_heart]
synonym: "angiogenesis involved in cardiac vascular morphogenesis" EXACT [GOC:mtg_heart]
synonym: "angiogenesis involved in heart vascular morphogenesis" EXACT [GOC:mtg_heart]
synonym: "coronary blood vessel angiogenesis" EXACT [GOC:mtg_heart]
synonym: "coronary vasculature angiogenesis" EXACT [GOC:mtg_heart]
is_a: GO:0001525 ! angiogenesis
intersection_of: GO:0001525 ! angiogenesis
intersection_of: part_of GO:0060976 ! coronary vasculature development
relationship: part_of GO:0060976 ! coronary vasculature development
relationship: part_of GO:0060977 ! coronary vasculature morphogenesis
created_by: dph
creation_date: 2009-10-06T02:02:12Z

[Term]
id: GO:0060979
name: vasculogenesis involved in coronary vascular morphogenesis
namespace: biological_process
def: "The differentiation of endothelial cells from progenitor cells that contributes to blood vessel development in the heart, and the de novo formation of blood vessels and tubes." [GOC:mtg_heart]
synonym: "coronary vasculogenesis" EXACT [GOC:mtg_heart]
synonym: "vasculogenesis involved in coronary blood vessel morphogenesis" EXACT [GOC:mtg_heart]
is_a: GO:0001570 ! vasculogenesis
intersection_of: GO:0001570 ! vasculogenesis
intersection_of: part_of GO:0060977 ! coronary vasculature morphogenesis
relationship: part_of GO:0060977 ! coronary vasculature morphogenesis
created_by: dph
creation_date: 2009-10-06T02:19:42Z

[Term]
id: GO:0060980
name: cell migration involved in coronary vasculogenesis
namespace: biological_process
def: "The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form the blood vessels of the heart." [GOC:mtg_heart]
is_a: GO:0035441 ! cell migration involved in vasculogenesis
is_a: GO:0060973 ! cell migration involved in heart development
intersection_of: GO:0016477 ! cell migration
intersection_of: part_of GO:0060979 ! vasculogenesis involved in coronary vascular morphogenesis
relationship: part_of GO:0060979 ! vasculogenesis involved in coronary vascular morphogenesis
created_by: dph
creation_date: 2009-10-06T02:33:06Z

[Term]
id: GO:0060981
name: cell migration involved in coronary angiogenesis
namespace: biological_process
def: "The orderly movement of a cell from one site to another that will contribute to the formation of new blood vessels in the heart from pre-existing blood vessels." [GOC:mtg_heart]
is_a: GO:0060973 ! cell migration involved in heart development
intersection_of: GO:0016477 ! cell migration
intersection_of: part_of GO:0060978 ! angiogenesis involved in coronary vascular morphogenesis
relationship: part_of GO:0060978 ! angiogenesis involved in coronary vascular morphogenesis
created_by: dph
creation_date: 2009-10-06T02:49:12Z

[Term]
id: GO:0060982
name: coronary artery morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of coronary arteries are generated and organized. Coronary arteries are blood vessels that transport blood to the heart muscle." [GOC:mtg_heart]
is_a: GO:0048844 ! artery morphogenesis
is_a: GO:0060977 ! coronary vasculature morphogenesis
created_by: dph
creation_date: 2009-10-06T02:58:52Z

[Term]
id: GO:0060983
name: epicardium-derived cardiac vascular smooth muscle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell derived from the epicardium acquires specialized features of a cardiac vascular smooth muscle cell. A cardiac vascular smooth muscle cell covers the heart vasculature and lacks transverse striations in its constituent fibers." [GOC:mtg_heart]
is_a: GO:0060947 ! cardiac vascular smooth muscle cell differentiation
created_by: dph
creation_date: 2009-10-06T03:05:33Z

[Term]
id: GO:0060984
name: epicardium-derived cardiac vascular smooth muscle cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cardiac vascular smooth muscle cell that was derived from the epicardium over time, from its formation to the mature state." [GOC:mtg_heart]
is_a: GO:0060948 ! cardiac vascular smooth muscle cell development
relationship: part_of GO:0060983 ! epicardium-derived cardiac vascular smooth muscle cell differentiation
created_by: dph
creation_date: 2009-10-06T03:07:09Z

[Term]
id: GO:0060985
name: epicardium-derived cardiac vascular smooth muscle cell fate commitment
namespace: biological_process
def: "The commitment of an epicardial cell to a cardiac vascular smooth muscle cell fate and its capacity to differentiate into a cardiac vascular smooth muscle cell." [GOC:mtg_heart]
is_a: GO:0060949 ! cardiac vascular smooth muscle cell fate commitment
relationship: part_of GO:0060983 ! epicardium-derived cardiac vascular smooth muscle cell differentiation
created_by: dph
creation_date: 2009-10-06T03:11:11Z

[Term]
id: GO:0060986
name: endocrine hormone secretion
namespace: biological_process
def: "The regulated release of a hormone into the circulatory system." [GOC:dph]
is_a: GO:0046879 ! hormone secretion
relationship: part_of GO:0050886 ! endocrine process
created_by: dph
creation_date: 2010-01-11T09:03:48Z

[Term]
id: GO:0060987
name: lipid tube
namespace: cellular_component
def: "A macromolecular complex that contains a tube of lipid surrounded by a protein coat." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0032994 ! protein-lipid complex
created_by: dph
creation_date: 2010-01-11T01:54:25Z

[Term]
id: GO:0060988
name: lipid tube assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of macromolecules to form a macromolecular complex that contains a tube of lipid surrounded by a protein coat involved in membrane shaping of vesicle membranes as the fuse or undergo fission." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "lipid tubulation" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0034622 ! cellular macromolecular complex assembly
is_a: GO:0065005 ! protein-lipid complex assembly
created_by: dph
creation_date: 2010-01-11T01:56:59Z

[Term]
id: GO:0060989
name: lipid tube assembly involved in organelle fusion
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of macromolecules to form a macromolecular complex that contains a tube of lipid surrounded by a protein coat involved in membrane shaping of vesicle membranes as organelles fuse." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "lipid tubulation involved in organelle fusion" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0060988 ! lipid tube assembly
intersection_of: GO:0060988 ! lipid tube assembly
intersection_of: part_of GO:0048284 ! organelle fusion
relationship: part_of GO:0048284 ! organelle fusion
created_by: dph
creation_date: 2010-01-11T02:06:50Z

[Term]
id: GO:0060990
name: lipid tube assembly involved in organelle fission
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of macromolecules to form a macromolecular complex that contains a tube of lipid surrounded by a protein coat involved in membrane shaping of vesicle membranes as organelles undergo fission." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "lipid tubulation involved in organelle fission" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0060988 ! lipid tube assembly
intersection_of: GO:0060988 ! lipid tube assembly
intersection_of: part_of GO:0048285 ! organelle fission
relationship: part_of GO:0048285 ! organelle fission
created_by: dph
creation_date: 2010-01-11T02:14:48Z

[Term]
id: GO:0060991
name: obsolete lipid tube assembly involved in cytokinesis
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of macromolecules to form a macromolecular complex that contains a tube of lipid surrounded by a protein coat involved in cytokinesis." [GOC:ascb_2009, GOC:dph, GOC:tb]
comment: This term was made obsolete because there is no evidence the process exists.
synonym: "lipid tube assembly involved in cytokinesis" EXACT []
synonym: "lipid tubulation involved in cytokinesis" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_obsolete: true
created_by: dph
creation_date: 2010-01-11T02:22:25Z

[Term]
id: GO:0060992
name: response to fungicide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fungicide stimulus. Fungicides are chemicals used to kill fungi." [GOC:dph]
is_a: GO:0009636 ! response to toxic substance
created_by: dph
creation_date: 2010-01-13T08:05:58Z

[Term]
id: GO:0060993
name: kidney morphogenesis
namespace: biological_process
def: "Morphogenesis of a kidney. A kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:dph, GOC:mtg_kidney_jan10]
is_a: GO:0009887 ! organ morphogenesis
relationship: part_of GO:0001822 ! kidney development
created_by: dph
creation_date: 2010-01-19T08:16:55Z

[Term]
id: GO:0060994
name: regulation of transcription from RNA polymerase II promoter involved in kidney development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the branching morphogenesis by which the kidney progresses from its initial formation to the mature state." [GOC:dph, GOC:mtg_kidney_jan10]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
intersection_of: part_of GO:0001822 ! kidney development
relationship: part_of GO:0001822 ! kidney development
created_by: dph
creation_date: 2010-01-19T08:24:46Z

[Term]
id: GO:0060995
name: cell-cell signaling involved in kidney development
namespace: biological_process
def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the kidney over time, from its formation to the mature organ." [GOC:dph, GOC:mtg_kidney_jan10]
synonym: "cell-cell signalling involved in kidney development" EXACT [GOC:mah]
is_a: GO:0007267 ! cell-cell signaling
intersection_of: GO:0007267 ! cell-cell signaling
intersection_of: part_of GO:0001822 ! kidney development
relationship: part_of GO:0001822 ! kidney development
created_by: dph
creation_date: 2010-01-19T08:33:40Z

[Term]
id: GO:0060996
name: dendritic spine development
namespace: biological_process
def: "The process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission." [GOC:dph]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0016358 ! dendrite development
created_by: dph
creation_date: 2010-01-20T09:06:33Z

[Term]
id: GO:0060997
name: dendritic spine morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission." [GOC:dph]
is_a: GO:0048812 ! neuron projection morphogenesis
is_a: GO:0097061 ! dendritic spine organization
relationship: part_of GO:0048813 ! dendrite morphogenesis
relationship: part_of GO:0060996 ! dendritic spine development
created_by: dph
creation_date: 2010-01-20T09:09:57Z

[Term]
id: GO:0060998
name: regulation of dendritic spine development
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure." [GOC:dph]
is_a: GO:0050773 ! regulation of dendrite development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060996 ! dendritic spine development
relationship: regulates GO:0060996 ! dendritic spine development
created_by: dph
creation_date: 2010-01-20T09:17:06Z

[Term]
id: GO:0060999
name: positive regulation of dendritic spine development
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure." [GOC:dph]
is_a: GO:0060998 ! regulation of dendritic spine development
is_a: GO:1900006 ! positive regulation of dendrite development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060996 ! dendritic spine development
relationship: positively_regulates GO:0060996 ! dendritic spine development
created_by: dph
creation_date: 2010-01-20T09:27:21Z

[Term]
id: GO:0061000
name: negative regulation of dendritic spine development
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure." [GOC:dph]
is_a: GO:0060998 ! regulation of dendritic spine development
is_a: GO:2000171 ! negative regulation of dendrite development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060996 ! dendritic spine development
relationship: negatively_regulates GO:0060996 ! dendritic spine development
created_by: dph
creation_date: 2010-01-20T09:29:18Z

[Term]
id: GO:0061001
name: regulation of dendritic spine morphogenesis
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission." [GOC:dph]
is_a: GO:0048814 ! regulation of dendrite morphogenesis
is_a: GO:0060998 ! regulation of dendritic spine development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060997 ! dendritic spine morphogenesis
relationship: regulates GO:0060997 ! dendritic spine morphogenesis
created_by: dph
creation_date: 2010-01-20T09:31:52Z

[Term]
id: GO:0061002
name: negative regulation of dendritic spine morphogenesis
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission." [GOC:dph]
is_a: GO:0050774 ! negative regulation of dendrite morphogenesis
is_a: GO:0061000 ! negative regulation of dendritic spine development
is_a: GO:0061001 ! regulation of dendritic spine morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060997 ! dendritic spine morphogenesis
relationship: negatively_regulates GO:0060997 ! dendritic spine morphogenesis
created_by: dph
creation_date: 2010-01-20T09:34:49Z

[Term]
id: GO:0061003
name: positive regulation of dendritic spine morphogenesis
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission." [GOC:dph]
is_a: GO:0050775 ! positive regulation of dendrite morphogenesis
is_a: GO:0060999 ! positive regulation of dendritic spine development
is_a: GO:0061001 ! regulation of dendritic spine morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060997 ! dendritic spine morphogenesis
relationship: positively_regulates GO:0060997 ! dendritic spine morphogenesis
created_by: dph
creation_date: 2010-01-20T09:36:54Z

[Term]
id: GO:0061004
name: pattern specification involved in kidney development
namespace: biological_process
def: "Any developmental process that results in the creation of defined areas or spaces within the kidney to which cells respond and eventually are instructed to differentiate." [GOC:dph, GOC:mtg_kidney_jan10]
synonym: "kidney pattern formation" RELATED [GOC:mtg_kidney_jan10]
synonym: "kidney pattern specification" EXACT [GOC:mtg_kidney_jan10]
synonym: "pattern formation involved in kidney development" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0007389 ! pattern specification process
intersection_of: GO:0007389 ! pattern specification process
intersection_of: part_of GO:0001822 ! kidney development
relationship: part_of GO:0001822 ! kidney development
relationship: part_of GO:0072048 ! renal system pattern specification
created_by: dph
creation_date: 2010-01-21T09:05:54Z

[Term]
id: GO:0061005
name: cell differentiation involved in kidney development
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the kidney as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: part_of GO:0001822 ! kidney development
relationship: part_of GO:0001822 ! kidney development
created_by: dph
creation_date: 2010-01-21T09:13:55Z

[Term]
id: GO:0061006
name: regulation of cell proliferation involved in kidney morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell proliferation that contributes to the shaping of the kidney." [GOC:dph, GOC:mtg_kidney_jan10]
is_a: GO:0042127 ! regulation of cell proliferation
intersection_of: GO:0042127 ! regulation of cell proliferation
intersection_of: part_of GO:0060993 ! kidney morphogenesis
relationship: part_of GO:0060993 ! kidney morphogenesis
created_by: dph
creation_date: 2010-01-21T11:25:23Z

[Term]
id: GO:0061007
name: hepaticobiliary system process
namespace: biological_process
def: "An system process carried out by any of the organs or tissues of the hepaticobiliary system. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins." [GOC:dph]
synonym: "hepatobiliary system process" EXACT [GOC:dph]
is_a: GO:0003008 ! system process
created_by: dph
creation_date: 2010-01-22T09:09:10Z

[Term]
id: GO:0061008
name: hepaticobiliary system development
namespace: biological_process
def: "The progression of the hepaticobiliary system over time, from its formation to the mature structure. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins." [GOC:dph]
synonym: "hepatobiliary system development" EXACT [GOC:dph]
is_a: GO:0048731 ! system development
created_by: dph
creation_date: 2010-01-22T09:11:59Z

[Term]
id: GO:0061009
name: common bile duct development
namespace: biological_process
def: "The progression of the common bile duct over time, from its formation to the mature structure. The common bile duct is formed from the joining of the common hepatic duct running from the liver, and the cystic duct running from the gall bladder. The common bile duct transports bile from the liver and gall bladder to the intestine." [PMID:20614624]
synonym: "bile duct development" EXACT [GOC:dph]
synonym: "CBD development" EXACT [PMID:20614624]
synonym: "EHBD development" BROAD [PMID:20614624]
synonym: "extrahepatic bile duct development" BROAD [PMID:20614624]
is_a: GO:0035295 ! tube development
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0061008 ! hepaticobiliary system development
created_by: dph
creation_date: 2010-01-22T09:17:13Z

[Term]
id: GO:0061010
name: gall bladder development
namespace: biological_process
def: "The progression of the gall bladder over time, from its initial formation to the mature structure. The gall bladder is a cavitated organ that stores bile." [GOC:dph]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048513 ! animal organ development
relationship: part_of GO:0061008 ! hepaticobiliary system development
created_by: dph
creation_date: 2010-01-22T09:38:44Z

[Term]
id: GO:0061011
name: hepatic duct development
namespace: biological_process
def: "The progression of the hepatic duct over time, from its formation to the mature structure. The hepatic duct is the duct that leads from the liver to the common bile duct." [GOC:dph, PMID:20614624]
is_a: GO:0061009 ! common bile duct development
relationship: part_of GO:0061008 ! hepaticobiliary system development
created_by: dph
creation_date: 2010-01-22T09:44:39Z

[Term]
id: GO:0061013
name: regulation of mRNA catabolic process
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "regulation of mRNA decay" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:1903311 ! regulation of mRNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006402 ! mRNA catabolic process
relationship: regulates GO:0006402 ! mRNA catabolic process
created_by: dph
creation_date: 2010-01-29T01:48:10Z

[Term]
id: GO:0061014
name: positive regulation of mRNA catabolic process
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "positive regulation of mRNA decay" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:0061013 ! regulation of mRNA catabolic process
is_a: GO:1903313 ! positive regulation of mRNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006402 ! mRNA catabolic process
relationship: positively_regulates GO:0006402 ! mRNA catabolic process
created_by: dph
creation_date: 2010-01-29T01:58:03Z

[Term]
id: GO:0061015
name: snRNA import into nucleus
namespace: biological_process
def: "The directed movement of snRNA, small nuclear ribonucleic acid into the nucleus." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0006404 ! RNA import into nucleus
is_a: GO:0051030 ! snRNA transport
is_a: GO:1902593 ! single-organism nuclear import
created_by: dph
creation_date: 2010-01-29T02:36:00Z

[Term]
id: GO:0061016
name: snRNA import into Cajal body
namespace: biological_process
def: "The directed movement of snRNA, small nuclear ribonucleic acid, into a Cajal body." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0051030 ! snRNA transport
created_by: dph
creation_date: 2010-01-29T02:40:50Z

[Term]
id: GO:0061017
name: hepatoblast differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a hepatoblast. A hepatoblast is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into hepatocytes and cholangiocytes." [GOC:dph, PMID:15226394]
is_a: GO:0030855 ! epithelial cell differentiation
is_a: GO:0048863 ! stem cell differentiation
relationship: part_of GO:0001889 ! liver development
created_by: dph
creation_date: 2010-02-02T09:08:03Z

[Term]
id: GO:0061024
name: membrane organization
namespace: biological_process
alt_id: GO:0016044
def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_pombe
synonym: "cellular membrane organisation" EXACT [GOC:curators]
synonym: "cellular membrane organization" EXACT []
synonym: "membrane organisation" EXACT [GOC:mah]
synonym: "membrane organization and biogenesis" RELATED [GOC:mah]
xref: Reactome:REACT_101524 "Membrane Trafficking, Dictyostelium discoideum"
xref: Reactome:REACT_103082 "Membrane Trafficking, Schizosaccharomyces pombe"
xref: Reactome:REACT_11123 "Membrane Trafficking, Homo sapiens"
xref: Reactome:REACT_29278 "Membrane Trafficking, Sus scrofa"
xref: Reactome:REACT_32337 "Membrane Trafficking, Taeniopygia guttata"
xref: Reactome:REACT_33741 "Membrane Trafficking, Bos taurus"
xref: Reactome:REACT_34084 "Membrane Trafficking, Caenorhabditis elegans"
xref: Reactome:REACT_78213 "Membrane Trafficking, Plasmodium falciparum"
xref: Reactome:REACT_78288 "Membrane Trafficking, Xenopus tropicalis"
xref: Reactome:REACT_83546 "Membrane Trafficking, Oryza sativa"
xref: Reactome:REACT_86557 "Membrane Trafficking, Arabidopsis thaliana"
xref: Reactome:REACT_87431 "Membrane Trafficking, Drosophila melanogaster"
xref: Reactome:REACT_88307 "Membrane Trafficking, Mus musculus"
xref: Reactome:REACT_91154 "Membrane Trafficking, Saccharomyces cerevisiae"
xref: Reactome:REACT_93714 "Membrane Trafficking, Danio rerio"
xref: Reactome:REACT_95586 "Membrane Trafficking, Gallus gallus"
xref: Reactome:REACT_96516 "Membrane Trafficking, Canis familiaris"
xref: Reactome:REACT_97881 "Membrane Trafficking, Rattus norvegicus"
is_a: GO:0016043 ! cellular component organization
created_by: dph
creation_date: 2010-02-08T02:43:11Z

[Term]
id: GO:0061025
name: membrane fusion
namespace: biological_process
alt_id: GO:0006944
def: "The membrane organization process that joins two lipid bilayers to form a single membrane." [GOC:dph, GOC:tb]
subset: goslim_yeast
synonym: "cellular membrane fusion" EXACT []
xref: Wikipedia:Lipid_bilayer_fusion
is_a: GO:0061024 ! membrane organization
created_by: dph
creation_date: 2010-02-08T02:48:06Z

[Term]
id: GO:0061026
name: cardiac muscle tissue regeneration
namespace: biological_process
def: "The regrowth of cardiac muscle tissue to repair injured or damaged muscle fibers in the postnatal stage." [GOC:dph]
is_a: GO:0042246 ! tissue regeneration
created_by: dph
creation_date: 2010-02-09T08:25:51Z

[Term]
id: GO:0061027
name: umbilical cord development
namespace: biological_process
def: "The process whose specific outcome is the development of the umbilical cord, from its formation to the mature structure. The umbilical cord is an organ or embryonic origin consisting of the 2 umbilical arteries and the one umbilical vein. The umbilical cord connects the cardiovascular system of the fetus to the mother via the placenta." [GOC:BHF, GOC:dph]
is_a: GO:0048856 ! anatomical structure development
created_by: dph
creation_date: 2010-02-09T09:09:22Z

[Term]
id: GO:0061028
name: establishment of endothelial barrier
namespace: biological_process
def: "The establishment of a barrier between endothelial cell layers, such as those in the brain, lung or intestine, to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition." [GOC:dph]
is_a: GO:0001885 ! endothelial cell development
created_by: dph
creation_date: 2010-02-09T09:26:59Z

[Term]
id: GO:0061029
name: eyelid development in camera-type eye
namespace: biological_process
def: "The progression of the eyelid in a camera-type eye from its formation to the mature state. The eyelid is a membranous cover that helps protect and lubricate the eye." [GOC:dph, GOC:yaf]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0043010 ! camera-type eye development
created_by: dph
creation_date: 2010-02-09T09:36:11Z

[Term]
id: GO:0061030
name: epithelial cell differentiation involved in mammary gland alveolus development
namespace: biological_process
def: "The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland alveolus." [GOC:dph, GOC:yaf]
is_a: GO:0060644 ! mammary gland epithelial cell differentiation
intersection_of: GO:0030855 ! epithelial cell differentiation
intersection_of: part_of GO:0060749 ! mammary gland alveolus development
relationship: part_of GO:0060749 ! mammary gland alveolus development
created_by: dph
creation_date: 2010-02-09T09:43:00Z

[Term]
id: GO:0061031
name: endodermal digestive tract morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the endodermal digestive tract are generated and organized. The endodermal digestive tract includes those portions of the digestive tract that are derived from endoderm." [GOC:dph, GOC:yaf]
is_a: GO:0048546 ! digestive tract morphogenesis
created_by: dph
creation_date: 2010-02-09T09:46:43Z

[Term]
id: GO:0061032
name: visceral serous pericardium development
namespace: biological_process
def: "The progression of the visceral serous pericardium from its formation to the mature structure. The visceral serous pericardium is the inner layer of the pericardium." [GOC:dph, GOC:yaf]
synonym: "epicardium development" EXACT [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0060039 ! pericardium development
created_by: dph
creation_date: 2010-02-09T09:52:49Z

[Term]
id: GO:0061033
name: secretion by lung epithelial cell involved in lung growth
namespace: biological_process
def: "The controlled release of liquid by a lung epithelial cell that contributes to an increase in size of the lung as part of its development." [GOC:dph]
synonym: "fetal lung liquid secretion" RELATED [GOC:dph]
is_a: GO:0032940 ! secretion by cell
relationship: part_of GO:0060437 ! lung growth
created_by: dph
creation_date: 2010-02-09T10:02:55Z

[Term]
id: GO:0061034
name: olfactory bulb mitral cell layer development
namespace: biological_process
def: "The progression of the olfactory bulb mitral cell layer over time from its initial formation until its mature state. The mitral cell layer is composed of pyramidal neurons whose cell bodies are located between the granule cell layer and the plexiform layer." [GOC:dph]
is_a: GO:0009888 ! tissue development
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0021772 ! olfactory bulb development
created_by: dph
creation_date: 2010-02-09T03:30:23Z

[Term]
id: GO:0061035
name: regulation of cartilage development
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph]
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051216 ! cartilage development
relationship: regulates GO:0051216 ! cartilage development
created_by: dph
creation_date: 2010-02-09T03:41:35Z

[Term]
id: GO:0061036
name: positive regulation of cartilage development
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0061035 ! regulation of cartilage development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051216 ! cartilage development
relationship: positively_regulates GO:0051216 ! cartilage development
created_by: dph
creation_date: 2010-02-09T03:41:35Z

[Term]
id: GO:0061037
name: negative regulation of cartilage development
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0061035 ! regulation of cartilage development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051216 ! cartilage development
relationship: negatively_regulates GO:0051216 ! cartilage development
created_by: dph
creation_date: 2010-02-09T03:41:35Z

[Term]
id: GO:0061038
name: uterus morphogenesis
namespace: biological_process
def: "The process in which anatomical structures of the uterus are generated and organized." [GOC:BHF, GOC:dph]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0009887 ! organ morphogenesis
is_a: GO:0044702 ! single organism reproductive process
relationship: part_of GO:0060065 ! uterus development
created_by: dph
creation_date: 2010-02-22T11:12:35Z

[Term]
id: GO:0061040
name: female gonad morphogenesis
namespace: biological_process
def: "The process in which a female gonad is generated and organized." [GOC:BHF, GOC:dph]
synonym: "ovary morphogenesis" RELATED [GOC:dph, GOC:tb]
is_a: GO:0035262 ! gonad morphogenesis
relationship: part_of GO:0008585 ! female gonad development
created_by: dph
creation_date: 2010-02-22T11:29:28Z

[Term]
id: GO:0061041
name: regulation of wound healing
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." [GOC:BHF, GOC:dph]
is_a: GO:1903034 ! regulation of response to wounding
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042060 ! wound healing
relationship: regulates GO:0042060 ! wound healing
created_by: dph
creation_date: 2010-02-25T10:14:37Z

[Term]
id: GO:0061042
name: vascular wound healing
namespace: biological_process
def: "Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature." [GOC:BHF, GOC:dph]
is_a: GO:0060055 ! angiogenesis involved in wound healing
created_by: dph
creation_date: 2010-02-25T10:18:26Z

[Term]
id: GO:0061043
name: regulation of vascular wound healing
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature." [GOC:dph]
is_a: GO:0045765 ! regulation of angiogenesis
is_a: GO:0061041 ! regulation of wound healing
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061042 ! vascular wound healing
relationship: regulates GO:0061042 ! vascular wound healing
created_by: dph
creation_date: 2010-02-25T10:21:59Z

[Term]
id: GO:0061044
name: negative regulation of vascular wound healing
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature." [GOC:BHF, GOC:dph]
is_a: GO:0016525 ! negative regulation of angiogenesis
is_a: GO:0061043 ! regulation of vascular wound healing
is_a: GO:0061045 ! negative regulation of wound healing
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061042 ! vascular wound healing
relationship: negatively_regulates GO:0061042 ! vascular wound healing
created_by: dph
creation_date: 2010-02-25T10:24:28Z

[Term]
id: GO:0061045
name: negative regulation of wound healing
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." [GOC:dph]
is_a: GO:0032102 ! negative regulation of response to external stimulus
is_a: GO:0061041 ! regulation of wound healing
is_a: GO:1903035 ! negative regulation of response to wounding
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042060 ! wound healing
relationship: negatively_regulates GO:0042060 ! wound healing
created_by: dph
creation_date: 2010-02-25T10:33:30Z

[Term]
id: GO:0061046
name: regulation of branching involved in lung morphogenesis
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units." [GOC:dph, GOC:yaf]
is_a: GO:0060688 ! regulation of morphogenesis of a branching structure
is_a: GO:2000027 ! regulation of organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060441 ! epithelial tube branching involved in lung morphogenesis
relationship: regulates GO:0060441 ! epithelial tube branching involved in lung morphogenesis
created_by: dph
creation_date: 2010-02-25T10:41:38Z

[Term]
id: GO:0061047
name: positive regulation of branching involved in lung morphogenesis
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units." [GOC:dph, GOC:yaf]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0061046 ! regulation of branching involved in lung morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060441 ! epithelial tube branching involved in lung morphogenesis
relationship: positively_regulates GO:0060441 ! epithelial tube branching involved in lung morphogenesis
created_by: dph
creation_date: 2010-02-25T10:50:01Z

[Term]
id: GO:0061048
name: negative regulation of branching involved in lung morphogenesis
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units." [GOC:dph, GOC:yaf]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0061046 ! regulation of branching involved in lung morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060441 ! epithelial tube branching involved in lung morphogenesis
relationship: negatively_regulates GO:0060441 ! epithelial tube branching involved in lung morphogenesis
created_by: dph
creation_date: 2010-02-25T10:51:31Z

[Term]
id: GO:0061049
name: cell growth involved in cardiac muscle cell development
namespace: biological_process
def: "The growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state." [GOC:dph]
synonym: "cardiac muscle cell hypertrophy" RELATED [GOC:dph]
synonym: "cardiomyocyte growth" RELATED [GOC:dph]
synonym: "heart muscle cell growth" RELATED [GOD:dph]
is_a: GO:0048588 ! developmental cell growth
intersection_of: GO:0016049 ! cell growth
intersection_of: part_of GO:0055013 ! cardiac muscle cell development
relationship: part_of GO:0003301 ! physiological cardiac muscle hypertrophy
relationship: part_of GO:0055013 ! cardiac muscle cell development
created_by: dph
creation_date: 2010-02-25T12:56:07Z

[Term]
id: GO:0061050
name: regulation of cell growth involved in cardiac muscle cell development
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state." [GOC:dph]
is_a: GO:0001558 ! regulation of cell growth
is_a: GO:0010611 ! regulation of cardiac muscle hypertrophy
is_a: GO:0055021 ! regulation of cardiac muscle tissue growth
is_a: GO:0060284 ! regulation of cell development
is_a: GO:2000725 ! regulation of cardiac muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061049 ! cell growth involved in cardiac muscle cell development
relationship: regulates GO:0061049 ! cell growth involved in cardiac muscle cell development
created_by: dph
creation_date: 2010-02-25T01:05:16Z

[Term]
id: GO:0061051
name: positive regulation of cell growth involved in cardiac muscle cell development
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state." [GOC:dph]
is_a: GO:0010613 ! positive regulation of cardiac muscle hypertrophy
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0030307 ! positive regulation of cell growth
is_a: GO:0055023 ! positive regulation of cardiac muscle tissue growth
is_a: GO:0061050 ! regulation of cell growth involved in cardiac muscle cell development
is_a: GO:2000727 ! positive regulation of cardiac muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061049 ! cell growth involved in cardiac muscle cell development
relationship: positively_regulates GO:0061049 ! cell growth involved in cardiac muscle cell development
created_by: dph
creation_date: 2010-02-25T01:08:08Z

[Term]
id: GO:0061052
name: negative regulation of cell growth involved in cardiac muscle cell development
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state." [GOC:dph]
is_a: GO:0010614 ! negative regulation of cardiac muscle hypertrophy
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0030308 ! negative regulation of cell growth
is_a: GO:0055022 ! negative regulation of cardiac muscle tissue growth
is_a: GO:0061050 ! regulation of cell growth involved in cardiac muscle cell development
is_a: GO:2000726 ! negative regulation of cardiac muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061049 ! cell growth involved in cardiac muscle cell development
relationship: negatively_regulates GO:0061049 ! cell growth involved in cardiac muscle cell development
created_by: dph
creation_date: 2010-02-25T01:11:30Z

[Term]
id: GO:0061053
name: somite development
namespace: biological_process
def: "The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo." [GOC:dph]
is_a: GO:0060429 ! epithelium development
relationship: part_of GO:0009790 ! embryo development
created_by: dph
creation_date: 2010-03-02T12:05:13Z

[Term]
id: GO:0061054
name: dermatome development
namespace: biological_process
def: "The progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin." [GOC:dph]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0061053 ! somite development
created_by: dph
creation_date: 2010-03-02T12:07:37Z

[Term]
id: GO:0061055
name: myotome development
namespace: biological_process
def: "The progression of the myotome over time, from its formation to the mature structure. The myotome is the portion of the somite that will give rise to muscle." [GOC:dph]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0061053 ! somite development
created_by: dph
creation_date: 2010-03-02T12:11:01Z

[Term]
id: GO:0061056
name: sclerotome development
namespace: biological_process
def: "The progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra." [GOC:dph]
is_a: GO:0060485 ! mesenchyme development
relationship: part_of GO:0061053 ! somite development
created_by: dph
creation_date: 2010-03-02T12:12:40Z

[Term]
id: GO:0061057
name: peptidoglycan recognition protein signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by binding of peptidoglycan to a receptor on the surface of the target cell and ending with regulation of a downstream cellular process. The main outcome of the Imd signaling is the production of antimicrobial peptides." [GOC:dph, PMID:18688280]
synonym: "Imd signaling pathway" EXACT [GOC:dph]
synonym: "Imd signalling pathway" EXACT [GOC:dph]
synonym: "immune deficiency pathway" RELATED [GOC:dph]
synonym: "immune deficiency signaling pathway" RELATED [GOC:dph]
synonym: "PGRP signaling pathway" RELATED [GOC:dph]
is_a: GO:0007166 ! cell surface receptor signaling pathway
relationship: part_of GO:0042742 ! defense response to bacterium
created_by: dph
creation_date: 2010-03-02T12:20:10Z

[Term]
id: GO:0061058
name: regulation of peptidoglycan recognition protein signaling pathway
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the peptidoglycan recognition protein signaling pathway." [GOC:dph]
synonym: "regulation of peptidoglycan recognition protein signalling pathway" EXACT [GOC:mah]
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:1900424 ! regulation of defense response to bacterium
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061057 ! peptidoglycan recognition protein signaling pathway
relationship: regulates GO:0061057 ! peptidoglycan recognition protein signaling pathway
created_by: dph
creation_date: 2010-03-02T12:35:40Z

[Term]
id: GO:0061059
name: positive regulation of peptidoglycan recognition protein signaling pathway
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the peptidoglycan recognition protein signaling pathway." [GOC:dph]
synonym: "positive regulation of peptidoglycan recognition protein signalling pathway" EXACT [GOC:mah]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0061058 ! regulation of peptidoglycan recognition protein signaling pathway
is_a: GO:1900426 ! positive regulation of defense response to bacterium
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061057 ! peptidoglycan recognition protein signaling pathway
relationship: positively_regulates GO:0061057 ! peptidoglycan recognition protein signaling pathway
created_by: dph
creation_date: 2010-03-02T12:37:44Z

[Term]
id: GO:0061060
name: negative regulation of peptidoglycan recognition protein signaling pathway
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the peptidoglycan recognition protein signaling pathway." [GOC:dph]
synonym: "negative regulation of peptidoglycan recognition protein signalling pathway" EXACT [GOC:mah]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0061058 ! regulation of peptidoglycan recognition protein signaling pathway
is_a: GO:1900425 ! negative regulation of defense response to bacterium
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061057 ! peptidoglycan recognition protein signaling pathway
relationship: negatively_regulates GO:0061057 ! peptidoglycan recognition protein signaling pathway
created_by: dph
creation_date: 2010-03-02T12:38:42Z

[Term]
id: GO:0061061
name: muscle structure development
namespace: biological_process
def: "The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms." [GOC:dph]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
created_by: dph
creation_date: 2010-03-09T08:55:14Z

[Term]
id: GO:0061062
name: regulation of nematode larval development
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew." [GOC:dph, GOC:kmv]
is_a: GO:0048580 ! regulation of post-embryonic development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002119 ! nematode larval development
relationship: regulates GO:0002119 ! nematode larval development
created_by: dph
creation_date: 2010-03-11T12:59:21Z

[Term]
id: GO:0061063
name: positive regulation of nematode larval development
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew." [GOC:dph, GOC:kmv]
is_a: GO:0048582 ! positive regulation of post-embryonic development
is_a: GO:0061062 ! regulation of nematode larval development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002119 ! nematode larval development
relationship: positively_regulates GO:0002119 ! nematode larval development
created_by: dph
creation_date: 2010-03-11T01:03:34Z

[Term]
id: GO:0061064
name: negative regulation of nematode larval development
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew." [GOC:dph, GOC:kmv]
is_a: GO:0048581 ! negative regulation of post-embryonic development
is_a: GO:0061062 ! regulation of nematode larval development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002119 ! nematode larval development
relationship: negatively_regulates GO:0002119 ! nematode larval development
created_by: dph
creation_date: 2010-03-11T01:04:39Z

[Term]
id: GO:0061065
name: regulation of dauer larval development
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of dauer larval development, the process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding." [GOC:dph, GOC:kmv]
is_a: GO:0061062 ! regulation of nematode larval development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0040024 ! dauer larval development
relationship: regulates GO:0040024 ! dauer larval development
created_by: dph
creation_date: 2010-03-11T01:07:07Z

[Term]
id: GO:0061066
name: positive regulation of dauer larval development
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of dauer larval development, the process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding." [GOC:dph, GOC:kmv]
is_a: GO:0061063 ! positive regulation of nematode larval development
is_a: GO:0061065 ! regulation of dauer larval development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0040024 ! dauer larval development
relationship: positively_regulates GO:0040024 ! dauer larval development
created_by: dph
creation_date: 2010-03-11T01:09:11Z

[Term]
id: GO:0061067
name: negative regulation of dauer larval development
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of dauer larval development, the process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding." [GOC:dph, GOC:kmv]
is_a: GO:0061064 ! negative regulation of nematode larval development
is_a: GO:0061065 ! regulation of dauer larval development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0040024 ! dauer larval development
relationship: negatively_regulates GO:0040024 ! dauer larval development
created_by: dph
creation_date: 2010-03-11T01:10:23Z

[Term]
id: GO:0061068
name: urethra development
namespace: biological_process
def: "The progression of the urethra over time from its initial formation to the mature structure. The urethra is a renal system organ that carries urine from the bladder to outside the body." [GOC:dph]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048513 ! animal organ development
relationship: part_of GO:0072001 ! renal system development
created_by: dph
creation_date: 2010-03-12T08:24:52Z

[Term]
id: GO:0061069
name: male urethra development
namespace: biological_process
def: "The progression of the male urethra over time from its initial formation to the mature structure. The male urethra is a renal system organ that carries urine from the bladder through the penis to outside the body." [GOC:dph]
is_a: GO:0061068 ! urethra development
created_by: dph
creation_date: 2010-03-12T08:28:19Z

[Term]
id: GO:0061070
name: female urethra development
namespace: biological_process
def: "The progression of the female urethra over time from its initial formation to the mature structure. The female urethra is a renal system organ that carries urine from the bladder to outside the body, exiting above the vaginal opening." [GOC:dph]
is_a: GO:0061068 ! urethra development
created_by: dph
creation_date: 2010-03-12T08:29:43Z

[Term]
id: GO:0061071
name: urethra epithelium development
namespace: biological_process
def: "The progression of the urethra epithelium over time from its initial formation to the mature structure. The urethra is a renal system organ that carries urine from the bladder to outside the body. The epithelium is the tubular, planar layer of cells through which the urine passes." [GOC:dph]
is_a: GO:0035295 ! tube development
is_a: GO:0060429 ! epithelium development
relationship: part_of GO:0061068 ! urethra development
created_by: dph
creation_date: 2010-03-12T08:36:53Z

[Term]
id: GO:0061072
name: iris morphogenesis
namespace: biological_process
def: "The process in which the iris is generated and organized. The iris is an anatomical structure in the eye whose opening forms the pupil. The iris is responsible for controlling the diameter and size of the pupil and the amount of light reaching the retina." [GOC:dph]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0048593 ! camera-type eye morphogenesis
created_by: dph
creation_date: 2010-03-16T10:48:42Z

[Term]
id: GO:0061073
name: ciliary body morphogenesis
namespace: biological_process
def: "The process in which the ciliary body generated and organized. The ciliary body is the circumferential tissue inside the eye composed of the ciliary muscle and ciliary processes." [GOC:dph]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0048593 ! camera-type eye morphogenesis
created_by: dph
creation_date: 2010-03-16T10:55:19Z

[Term]
id: GO:0061074
name: regulation of neural retina development
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells." [GOC:dph]
is_a: GO:1902866 ! regulation of retina development in camera-type eye
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003407 ! neural retina development
relationship: regulates GO:0003407 ! neural retina development
created_by: dph
creation_date: 2010-03-16T11:47:05Z

[Term]
id: GO:0061075
name: positive regulation of neural retina development
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells." [GOC:dph]
is_a: GO:0061074 ! regulation of neural retina development
is_a: GO:1902868 ! positive regulation of retina development in camera-type eye
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003407 ! neural retina development
relationship: positively_regulates GO:0003407 ! neural retina development
created_by: dph
creation_date: 2010-03-16T11:59:48Z

[Term]
id: GO:0061076
name: negative regulation of neural retina development
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells." [GOC:dph]
is_a: GO:0061074 ! regulation of neural retina development
is_a: GO:1902867 ! negative regulation of retina development in camera-type eye
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003407 ! neural retina development
relationship: negatively_regulates GO:0003407 ! neural retina development
created_by: dph
creation_date: 2010-03-16T12:46:11Z

[Term]
id: GO:0061077
name: chaperone-mediated protein folding
namespace: biological_process
def: "The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone." [GOC:dph, GOC:vw]
is_a: GO:0006457 ! protein folding
created_by: dph
creation_date: 2010-04-06T03:28:55Z

[Term]
id: GO:0061078
name: positive regulation of prostaglandin secretion involved in immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a prostaglandin from a cell and contributes to the immune response." [GOC:BHF, GOC:dph]
synonym: "positive regulation of prostaglandin secretion during immune response" RELATED [GOC:dph]
is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response
is_a: GO:0032308 ! positive regulation of prostaglandin secretion
is_a: GO:0050778 ! positive regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0090323 ! prostaglandin secretion involved in immune response
relationship: positively_regulates GO:0090323 ! prostaglandin secretion involved in immune response
created_by: dph
creation_date: 2010-04-08T01:53:45Z

[Term]
id: GO:0061079
name: left horn of sinus venosus development
namespace: biological_process
def: "The progression of the left horn of the sinus venosus from its initial formation to the mature structure." [GOC:dph]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0003235 ! sinus venosus development
created_by: dph
creation_date: 2010-04-08T02:40:27Z

[Term]
id: GO:0061080
name: right horn of sinus venosus development
namespace: biological_process
def: "The progression of the right horn of the sinus venosus from its formation to the mature structure." [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0003235 ! sinus venosus development
created_by: dph
creation_date: 2010-04-08T02:45:10Z

[Term]
id: GO:0061081
name: positive regulation of myeloid leukocyte cytokine production involved in immune response
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the production of a cytokine that contributes to the immune response." [GOC:BHF, GOC:dph]
synonym: "positive regulation of myeloid cell cytokine production involved in immune response" RELATED [GOC:dph]
is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061082 ! myeloid leukocyte cytokine production
relationship: positively_regulates GO:0061082 ! myeloid leukocyte cytokine production
created_by: dph
creation_date: 2010-04-13T11:26:41Z

[Term]
id: GO:0061082
name: myeloid leukocyte cytokine production
namespace: biological_process
def: "Any process that contributes to cytokine production by a myeloid cell." [GOC:dph]
is_a: GO:0002367 ! cytokine production involved in immune response
created_by: dph
creation_date: 2010-04-13T11:29:42Z

[Term]
id: GO:0061083
name: regulation of protein refolding
namespace: biological_process
def: "Any process that regulates the rate, frequency, or extent of protein refolding. Protein refolding is the process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones." [GOC:dph, GOC:tb]
is_a: GO:1903332 ! regulation of protein folding
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042026 ! protein refolding
relationship: regulates GO:0042026 ! protein refolding
created_by: dph
creation_date: 2010-04-26T01:07:54Z

[Term]
id: GO:0061084
name: negative regulation of protein refolding
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of protein refolding. Protein refolding is the process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0061083 ! regulation of protein refolding
is_a: GO:1903333 ! negative regulation of protein folding
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042026 ! protein refolding
relationship: negatively_regulates GO:0042026 ! protein refolding
created_by: dph
creation_date: 2010-04-26T01:11:29Z

[Term]
id: GO:0061085
name: regulation of histone H3-K27 methylation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of histone H3-K27 methylation. Histone H3-K27 methylation is the modification of histone H3 by addition of a methyl group to lysine at position 27 of the histone." [GOC:dph, GOC:tb]
is_a: GO:0031060 ! regulation of histone methylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070734 ! histone H3-K27 methylation
relationship: regulates GO:0070734 ! histone H3-K27 methylation
created_by: dph
creation_date: 2010-04-26T01:23:52Z

[Term]
id: GO:0061086
name: negative regulation of histone H3-K27 methylation
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of histone H3-K27 methylation. Histone H3-K27 methylation is the modification of histone H3 by addition of a methyl group to lysine at position 27 of the histone." [GOC:dph, GOC:tb]
is_a: GO:0031061 ! negative regulation of histone methylation
is_a: GO:0061085 ! regulation of histone H3-K27 methylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070734 ! histone H3-K27 methylation
relationship: negatively_regulates GO:0070734 ! histone H3-K27 methylation
created_by: dph
creation_date: 2010-04-26T01:23:52Z

[Term]
id: GO:0061087
name: positive regulation of histone H3-K27 methylation
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of histone H3-K27 methylation. Histone H3-K27 methylation is the modification of histone H3 by addition of a methyl group to lysine at position 27 of the histone." [GOC:dph, GOC:tb]
is_a: GO:0031062 ! positive regulation of histone methylation
is_a: GO:0061085 ! regulation of histone H3-K27 methylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070734 ! histone H3-K27 methylation
relationship: positively_regulates GO:0070734 ! histone H3-K27 methylation
created_by: dph
creation_date: 2010-04-26T01:23:52Z

[Term]
id: GO:0061088
name: regulation of sequestering of zinc ion
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of sequestering of zinc ion. Sequestering of zinc ion is the process of binding or confining zinc ions such that they are separated from other components of a biological system." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0032879 ! regulation of localization
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:2000021 ! regulation of ion homeostasis
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0032119 ! sequestering of zinc ion
relationship: regulates GO:0032119 ! sequestering of zinc ion
created_by: dph
creation_date: 2010-04-26T01:38:53Z

[Term]
id: GO:0061089
name: negative regulation of sequestering of zinc ion
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of sequestering of zinc ion. Sequestering of zinc ion is the process of binding or confining zinc ions such that they are separated from other components of a biological system." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0032845 ! negative regulation of homeostatic process
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0061088 ! regulation of sequestering of zinc ion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032119 ! sequestering of zinc ion
relationship: negatively_regulates GO:0032119 ! sequestering of zinc ion
created_by: dph
creation_date: 2010-04-26T01:38:53Z

[Term]
id: GO:0061090
name: positive regulation of sequestering of zinc ion
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of sequestering of zinc ion. Sequestering of zinc ion is the process of binding or confining zinc ions such that they are separated from other components of a biological system." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0032846 ! positive regulation of homeostatic process
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0061088 ! regulation of sequestering of zinc ion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032119 ! sequestering of zinc ion
relationship: positively_regulates GO:0032119 ! sequestering of zinc ion
created_by: dph
creation_date: 2010-04-26T01:38:53Z

[Term]
id: GO:0061091
name: regulation of phospholipid translocation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the translocation, or flipping, of phospholipid molecules from one monolayer of a membrane bilayer to the opposite monolayer." [GOC:dph, GOC:jh, GOC:tb, PMID:19966303]
is_a: GO:0051128 ! regulation of cellular component organization
is_a: GO:0097035 ! regulation of membrane lipid distribution
is_a: GO:2001138 ! regulation of phospholipid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045332 ! phospholipid translocation
relationship: regulates GO:0045332 ! phospholipid translocation
created_by: dph
creation_date: 2010-04-26T01:54:22Z

[Term]
id: GO:0061092
name: positive regulation of phospholipid translocation
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the translocation, or flipping, of phospholipid molecules from one monolayer of a membrane bilayer to the opposite monolayer." [GOC:dph, GOC:jh, GOC:tb, PMID:19966303]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:0061091 ! regulation of phospholipid translocation
is_a: GO:2001140 ! positive regulation of phospholipid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045332 ! phospholipid translocation
relationship: positively_regulates GO:0045332 ! phospholipid translocation
created_by: dph
creation_date: 2010-04-26T01:54:22Z

[Term]
id: GO:0061093
name: negative regulation of phospholipid translocation
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the translocation, or flipping, of phospholipid molecules from one monolayer of a membrane bilayer to the opposite monolayer." [GOC:dph, GOC:jh, GOC:tb, PMID:19966303]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:0061091 ! regulation of phospholipid translocation
is_a: GO:2001139 ! negative regulation of phospholipid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045332 ! phospholipid translocation
relationship: negatively_regulates GO:0045332 ! phospholipid translocation
created_by: dph
creation_date: 2010-04-26T01:54:22Z

[Term]
id: GO:0061094
name: regulation of turning behavior involved in mating
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of turning behavior involved in mating. Turning behavior is the sharp ventral turn performed by the male as he approaches either the hermaphrodite head or tail, whilst trying to locate his partner's vulva. Turning occurs via a sharp ventral coil of the male's tail." [GOC:dph, GOC:tb]
is_a: GO:1902435 ! regulation of male mating behavior
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034607 ! turning behavior involved in mating
relationship: regulates GO:0034607 ! turning behavior involved in mating
created_by: dph
creation_date: 2010-04-26T02:12:24Z

[Term]
id: GO:0061095
name: positive regulation of turning behavior involved in mating
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of turning behavior involved in mating. Turning behavior is the sharp ventral turn performed by the male as he approaches either the hermaphrodite head or tail, whilst trying to locate his partner's vulva. Turning occurs via a sharp ventral coil of the male's tail." [GOC:dph, GOC:tb]
is_a: GO:0061094 ! regulation of turning behavior involved in mating
is_a: GO:1902437 ! positive regulation of male mating behavior
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034607 ! turning behavior involved in mating
relationship: positively_regulates GO:0034607 ! turning behavior involved in mating
created_by: dph
creation_date: 2010-04-26T02:12:24Z

[Term]
id: GO:0061096
name: negative regulation of turning behavior involved in mating
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of turning behavior involved in mating. Turning behavior is the sharp ventral turn performed by the male as he approaches either the hermaphrodite head or tail, whilst trying to locate his partner's vulva. Turning occurs via a sharp ventral coil of the male's tail." [GOC:dph, GOC:tb]
is_a: GO:0061094 ! regulation of turning behavior involved in mating
is_a: GO:1902436 ! negative regulation of male mating behavior
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034607 ! turning behavior involved in mating
relationship: negatively_regulates GO:0034607 ! turning behavior involved in mating
created_by: dph
creation_date: 2010-04-26T02:12:24Z

[Term]
id: GO:0061097
name: regulation of protein tyrosine kinase activity
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of protein tyrosine kinase activity." [GOC:dph, GOC:tb]
is_a: GO:0045859 ! regulation of protein kinase activity
is_a: GO:0050730 ! regulation of peptidyl-tyrosine phosphorylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004713 ! protein tyrosine kinase activity
relationship: regulates GO:0004713 ! protein tyrosine kinase activity
created_by: dph
creation_date: 2010-04-26T02:34:53Z

[Term]
id: GO:0061098
name: positive regulation of protein tyrosine kinase activity
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of protein tyrosine kinase activity." [GOC:dph, GOC:tb]
is_a: GO:0045860 ! positive regulation of protein kinase activity
is_a: GO:0050731 ! positive regulation of peptidyl-tyrosine phosphorylation
is_a: GO:0061097 ! regulation of protein tyrosine kinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004713 ! protein tyrosine kinase activity
relationship: positively_regulates GO:0004713 ! protein tyrosine kinase activity
created_by: dph
creation_date: 2010-04-26T02:34:53Z

[Term]
id: GO:0061099
name: negative regulation of protein tyrosine kinase activity
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of protein tyrosine kinase activity." [GOC:dph, GOC:tb]
is_a: GO:0006469 ! negative regulation of protein kinase activity
is_a: GO:0050732 ! negative regulation of peptidyl-tyrosine phosphorylation
is_a: GO:0061097 ! regulation of protein tyrosine kinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004713 ! protein tyrosine kinase activity
relationship: negatively_regulates GO:0004713 ! protein tyrosine kinase activity
created_by: dph
creation_date: 2010-04-26T02:34:53Z

[Term]
id: GO:0061100
name: lung neuroendocrine cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the lung epithelium." [GOC:dph, PMID:9126746]
is_a: GO:0061101 ! neuroendocrine cell differentiation
is_a: GO:0061140 ! lung secretory cell differentiation
created_by: dph
creation_date: 2010-04-27T03:28:46Z

[Term]
id: GO:0061101
name: neuroendocrine cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a neuroendocrine cell. A neuroendocrine cell is a cell that receives input form a neuron which controls the secretion of an endocrine substance." [GOC:dph]
is_a: GO:0060563 ! neuroepithelial cell differentiation
created_by: dph
creation_date: 2010-04-28T09:42:20Z

[Term]
id: GO:0061102
name: stomach neuroendocrine cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the stomach epithelium." [GOC:dph, PMID:18173746]
synonym: "gastric neuroendocrine cell differentiation" RELATED [GOC:dph]
is_a: GO:0061101 ! neuroendocrine cell differentiation
relationship: part_of GO:0048513 ! animal organ development
relationship: part_of GO:0048565 ! digestive tract development
created_by: dph
creation_date: 2010-04-28T09:47:07Z

[Term]
id: GO:0061103
name: carotid body glomus cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a glomus cell of the carotid body. The carotid body is a specialized chemosensory organ that helps respond to hypoxia." [GOC:dph, PMID:6243386]
is_a: GO:0061101 ! neuroendocrine cell differentiation
relationship: part_of GO:0048513 ! animal organ development
created_by: dph
creation_date: 2010-04-28T10:59:24Z

[Term]
id: GO:0061104
name: adrenal chromaffin cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an adrenal chromaffin cell. An adrenal chromaffin cell is a neuroendocrine cell that stores epinephrine secretory vesicles." [GOC:dph]
is_a: GO:0002067 ! glandular epithelial cell differentiation
is_a: GO:0061101 ! neuroendocrine cell differentiation
relationship: part_of GO:0030325 ! adrenal gland development
created_by: dph
creation_date: 2010-04-29T08:27:53Z

[Term]
id: GO:0061105
name: regulation of stomach neuroendocrine cell differentiation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the differentiation of a neuroendocrine cell in the stomach." [GOC:dph]
is_a: GO:0030856 ! regulation of epithelial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061102 ! stomach neuroendocrine cell differentiation
relationship: regulates GO:0061102 ! stomach neuroendocrine cell differentiation
created_by: dph
creation_date: 2010-04-29T12:19:37Z

[Term]
id: GO:0061106
name: negative regulation of stomach neuroendocrine cell differentiation
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the differentiation of a neuroendocrine cell in the stomach." [GOC:dph]
is_a: GO:0002085 ! inhibition of neuroepithelial cell differentiation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0061105 ! regulation of stomach neuroendocrine cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061102 ! stomach neuroendocrine cell differentiation
relationship: negatively_regulates GO:0061102 ! stomach neuroendocrine cell differentiation
created_by: dph
creation_date: 2010-04-29T12:23:05Z

[Term]
id: GO:0061107
name: seminal vesicle development
namespace: biological_process
def: "The progression of the seminal vesicle over time, from its formation to the mature structure. The seminal vesicle is a gland that contributes to the production of semen." [GOC:dph]
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0048608 ! reproductive structure development
is_a: GO:0048732 ! gland development
created_by: dph
creation_date: 2010-04-30T10:17:30Z

[Term]
id: GO:0061108
name: seminal vesicle epithelium development
namespace: biological_process
def: "The progression of the seminal vesicle epithelium over time, from its formation to the mature structure." [GOC:dph]
is_a: GO:0035295 ! tube development
is_a: GO:0048608 ! reproductive structure development
is_a: GO:0060429 ! epithelium development
relationship: part_of GO:0061107 ! seminal vesicle development
created_by: dph
creation_date: 2010-04-30T10:19:54Z

[Term]
id: GO:0061109
name: dense core granule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dense core granule. A dense core granule is a secretory organelle found in endocrine cells." [GOC:dph]
synonym: "dense core granule organisation" EXACT [GOC:mah]
is_a: GO:0033363 ! secretory granule organization
created_by: dph
creation_date: 2010-05-01T09:34:37Z

[Term]
id: GO:0061110
name: dense core granule biogenesis
namespace: biological_process
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a dense core granule. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the dense core granule." [GOC:dph]
is_a: GO:0044085 ! cellular component biogenesis
created_by: dph
creation_date: 2010-05-01T09:40:11Z

[Term]
id: GO:0061111
name: epithelial-mesenchymal cell signaling involved in lung development
namespace: biological_process
def: "Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell and contributes to the progression of the lung over time from its initial formation to the mature organ." [GOC:dph]
synonym: "epithelial-mesenchymal cell signalling involved in lung development" EXACT [GOC:mah]
is_a: GO:0060495 ! cell-cell signaling involved in lung development
is_a: GO:0060684 ! epithelial-mesenchymal cell signaling
intersection_of: GO:0060684 ! epithelial-mesenchymal cell signaling
intersection_of: part_of GO:0030324 ! lung development
relationship: part_of GO:0030324 ! lung development
created_by: dph
creation_date: 2010-05-05T11:14:38Z

[Term]
id: GO:0061112
name: negative regulation of bud outgrowth involved in lung branching
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of bud outgrowth involved in lung branching." [GOC:dph]
is_a: GO:0048640 ! negative regulation of developmental growth
is_a: GO:0061048 ! negative regulation of branching involved in lung morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060447 ! bud outgrowth involved in lung branching
relationship: negatively_regulates GO:0060447 ! bud outgrowth involved in lung branching
created_by: dph
creation_date: 2010-05-05T11:20:42Z

[Term]
id: GO:0061113
name: pancreas morphogenesis
namespace: biological_process
def: "Morphogenesis of the pancreas. Morphogenesis is the process in which anatomical structures are generated and organized." [GOC:dph]
is_a: GO:0009887 ! organ morphogenesis
relationship: part_of GO:0031016 ! pancreas development
created_by: dph
creation_date: 2010-05-05T11:55:30Z

[Term]
id: GO:0061114
name: branching involved in pancreas morphogenesis
namespace: biological_process
def: "The process in which the branches of the pancreas are generated and organized." [GOC:dph]
is_a: GO:0061138 ! morphogenesis of a branching epithelium
intersection_of: GO:0061138 ! morphogenesis of a branching epithelium
intersection_of: part_of GO:0061113 ! pancreas morphogenesis
relationship: part_of GO:0061113 ! pancreas morphogenesis
created_by: dph
creation_date: 2010-05-05T12:03:04Z

[Term]
id: GO:0061115
name: lung proximal/distal axis specification
namespace: biological_process
def: "The establishment, maintenance and elaboration of the proximal/distal axis of the lung. The proximal/distal axis of the lung is defined by a line that runs from the trachea to the alveoli." [GOC:dph]
is_a: GO:0009946 ! proximal/distal axis specification
is_a: GO:0060432 ! lung pattern specification process
created_by: dph
creation_date: 2010-05-10T12:30:40Z

[Term]
id: GO:0061116
name: ductus venosus closure
namespace: biological_process
def: "The morphogenesis process in which the ductus venosus changes to no longer permit blood flow after birth." [GOC:dph]
is_a: GO:0048845 ! venous blood vessel morphogenesis
created_by: dph
creation_date: 2010-05-17T07:21:53Z

[Term]
id: GO:0061117
name: negative regulation of heart growth
namespace: biological_process
def: "Any process that decreases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart." [GOC:dph, GOC:hjd]
is_a: GO:0046621 ! negative regulation of organ growth
is_a: GO:0060420 ! regulation of heart growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060419 ! heart growth
relationship: negatively_regulates GO:0060419 ! heart growth
created_by: dph
creation_date: 2010-05-17T07:31:28Z

[Term]
id: GO:0061118
name: regulation of positive chemotaxis to cAMP
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP." [GOC:dph]
is_a: GO:0050926 ! regulation of positive chemotaxis
relationship: regulates GO:0043327 ! chemotaxis to cAMP
created_by: dph
creation_date: 2010-05-17T07:47:47Z

[Term]
id: GO:0061119
name: regulation of positive chemotaxis to cAMP by chlorinated alkylphenone
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of a chlorinated alkylphenone. An alkylphenone is an aromatic polyketide with methyl and chlorine substitutions." [GOC:dph, PMID:19684855]
is_a: GO:0061118 ! regulation of positive chemotaxis to cAMP
created_by: dph
creation_date: 2010-05-17T07:53:58Z

[Term]
id: GO:0061120
name: regulation of positive chemotaxis to cAMP by DIF-1
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-1. DIF-1 is a chlorinated alkylphenone." [GOC:dph]
is_a: GO:0061119 ! regulation of positive chemotaxis to cAMP by chlorinated alkylphenone
created_by: dph
creation_date: 2010-05-17T08:10:20Z

[Term]
id: GO:0061121
name: regulation of positive chemotaxis to cAMP by DIF-2
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-2. DIF-2 is a chlorinated alkylphenone." [GOC:dph]
is_a: GO:0061119 ! regulation of positive chemotaxis to cAMP by chlorinated alkylphenone
created_by: dph
creation_date: 2010-05-17T08:16:21Z

[Term]
id: GO:0061122
name: positive regulation of positive chemotaxis to cAMP
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP." [GOC:dph]
is_a: GO:0050927 ! positive regulation of positive chemotaxis
is_a: GO:0061118 ! regulation of positive chemotaxis to cAMP
relationship: positively_regulates GO:0043327 ! chemotaxis to cAMP
created_by: dph
creation_date: 2010-05-17T08:25:55Z

[Term]
id: GO:0061123
name: negative regulation of positive chemotaxis to cAMP
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP." [GOC:dph]
is_a: GO:0050928 ! negative regulation of positive chemotaxis
is_a: GO:0061118 ! regulation of positive chemotaxis to cAMP
relationship: negatively_regulates GO:0043327 ! chemotaxis to cAMP
created_by: dph
creation_date: 2010-05-17T08:27:20Z

[Term]
id: GO:0061124
name: positive regulation of positive chemotaxis to cAMP by chlorinated alkylphenone
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of a chlorinated alkylphenone. An alkylphenone is an aromatic polyketide with methyl and chlorine substitutions." [GOC:dph]
is_a: GO:0061119 ! regulation of positive chemotaxis to cAMP by chlorinated alkylphenone
is_a: GO:0061122 ! positive regulation of positive chemotaxis to cAMP
created_by: dph
creation_date: 2010-05-17T08:33:40Z

[Term]
id: GO:0061125
name: negative regulation of positive chemotaxis to cAMP by chlorinated alkylphenone
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of a chlorinated alkylphenone. An alkylphenone is an aromatic polyketide with methyl and chlorine substitutions." [GOC:dph]
is_a: GO:0061119 ! regulation of positive chemotaxis to cAMP by chlorinated alkylphenone
is_a: GO:0061123 ! negative regulation of positive chemotaxis to cAMP
created_by: dph
creation_date: 2010-05-17T08:36:55Z

[Term]
id: GO:0061126
name: positive regulation of positive chemotaxis to cAMP by DIF-1
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-1. DIF-1 is a chlorinated alkylphenone." [GOC:dph]
is_a: GO:0061120 ! regulation of positive chemotaxis to cAMP by DIF-1
is_a: GO:0061124 ! positive regulation of positive chemotaxis to cAMP by chlorinated alkylphenone
created_by: dph
creation_date: 2010-05-17T08:41:04Z

[Term]
id: GO:0061127
name: negative regulation of positive chemotaxis to cAMP by DIF-1
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-1. DIF-1 is a chlorinated alkylphenone." [GOC:dph]
is_a: GO:0061120 ! regulation of positive chemotaxis to cAMP by DIF-1
is_a: GO:0061125 ! negative regulation of positive chemotaxis to cAMP by chlorinated alkylphenone
created_by: dph
creation_date: 2010-05-17T08:45:03Z

[Term]
id: GO:0061128
name: positive regulation of chemotaxis to cAMP by DIF-2
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-2. DIF-2 is a chlorinated alkylphenone." [GOC:dph]
is_a: GO:0061121 ! regulation of positive chemotaxis to cAMP by DIF-2
is_a: GO:0061124 ! positive regulation of positive chemotaxis to cAMP by chlorinated alkylphenone
created_by: dph
creation_date: 2010-05-17T08:48:17Z

[Term]
id: GO:0061129
name: negative regulation of positive chemotaxis to cAMP by DIF-2
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-2. DIF-2 is a chlorinated alkylphenone." [GOC:dph]
is_a: GO:0061121 ! regulation of positive chemotaxis to cAMP by DIF-2
is_a: GO:0061125 ! negative regulation of positive chemotaxis to cAMP by chlorinated alkylphenone
created_by: dph
creation_date: 2010-05-17T08:50:33Z

[Term]
id: GO:0061130
name: pancreatic bud formation
namespace: biological_process
def: "The morphogenetic process in which the foregut region specified to become the pancreas forms a bud." [GOC:dph]
is_a: GO:0048645 ! organ formation
is_a: GO:0061114 ! branching involved in pancreas morphogenesis
is_a: GO:0072175 ! epithelial tube formation
created_by: dph
creation_date: 2010-05-17T09:33:40Z

[Term]
id: GO:0061131
name: pancreas field specification
namespace: biological_process
def: "The process in which a specific region of the gut is delineated into the area in which the pancreas will develop." [GOC:dph]
is_a: GO:0010092 ! specification of organ identity
relationship: part_of GO:0061130 ! pancreatic bud formation
created_by: dph
creation_date: 2010-05-17T09:39:49Z

[Term]
id: GO:0061132
name: pancreas induction
namespace: biological_process
def: "The close range interaction of two or more cells or tissues that causes the cells of the gut to change their fates and specify the development of the pancreas." [GOC:dph]
is_a: GO:0001759 ! organ induction
is_a: GO:0060688 ! regulation of morphogenesis of a branching structure
intersection_of: GO:0001759 ! organ induction
intersection_of: positively_regulates GO:0061131 ! pancreas field specification
relationship: positively_regulates GO:0061131 ! pancreas field specification
created_by: dph
creation_date: 2010-05-17T09:45:32Z

[Term]
id: GO:0061133
name: endopeptidase activator activity
namespace: molecular_function
def: "Increases the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides." [GOC:dph, GOC:tb]
is_a: GO:0016504 ! peptidase activator activity
is_a: GO:0061135 ! endopeptidase regulator activity
relationship: part_of GO:0010950 ! positive regulation of endopeptidase activity
relationship: positively_regulates GO:0004175 ! endopeptidase activity
created_by: dph
creation_date: 2010-05-17T01:08:29Z

[Term]
id: GO:0061134
name: peptidase regulator activity
namespace: molecular_function
def: "Modulates the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:dph, GOC:tb]
is_a: GO:0030234 ! enzyme regulator activity
relationship: has_part GO:0002020 ! protease binding
relationship: part_of GO:0052547 ! regulation of peptidase activity
relationship: regulates GO:0008233 ! peptidase activity
created_by: dph
creation_date: 2010-05-17T01:15:24Z

[Term]
id: GO:0061135
name: endopeptidase regulator activity
namespace: molecular_function
def: "Modulates the activity of a peptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides." [GOC:dph, GOC:tb]
is_a: GO:0061134 ! peptidase regulator activity
relationship: part_of GO:0052548 ! regulation of endopeptidase activity
relationship: regulates GO:0004175 ! endopeptidase activity
created_by: dph
creation_date: 2010-05-17T01:19:36Z

[Term]
id: GO:0061136
name: regulation of proteasomal protein catabolic process
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:dph, GOC:tb]
is_a: GO:1903050 ! regulation of proteolysis involved in cellular protein catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010498 ! proteasomal protein catabolic process
relationship: regulates GO:0010498 ! proteasomal protein catabolic process
created_by: dph
creation_date: 2010-05-17T01:33:20Z

[Term]
id: GO:0061137
name: bud dilation
namespace: biological_process
def: "The process in which a branch bud increases radially. A branch bud is the initial area of outgrowth in the formation of a new branch." [GOC:dph]
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0001763 ! morphogenesis of a branching structure
created_by: dph
creation_date: 2010-05-20T07:54:42Z

[Term]
id: GO:0061138
name: morphogenesis of a branching epithelium
namespace: biological_process
def: "The process in which the anatomical structures of a branched epithelium are generated and organized." [GOC:dph]
is_a: GO:0001763 ! morphogenesis of a branching structure
is_a: GO:0002009 ! morphogenesis of an epithelium
created_by: dph
creation_date: 2010-05-25T09:05:34Z

[Term]
id: GO:0061139
name: bud field specification
namespace: biological_process
def: "The regionalization process in which the identity of a bud primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:dph]
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0061138 ! morphogenesis of a branching epithelium
created_by: dph
creation_date: 2010-05-25T09:21:01Z

[Term]
id: GO:0061140
name: lung secretory cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a lung secretory cell. A lung secretory cell is a specialized epithelial cell of the lung that contains large secretory granules in its apical part." [GOC:dph]
is_a: GO:0060487 ! lung epithelial cell differentiation
created_by: dph
creation_date: 2010-05-25T09:28:53Z

[Term]
id: GO:0061141
name: lung ciliated cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a lung ciliated cell. A lung ciliated cell is a specialized lung epithelial cell that contains a motile cilium for moving substances released from lung secretory cells." [GOC:dph]
is_a: GO:0060487 ! lung epithelial cell differentiation
created_by: dph
creation_date: 2010-05-25T09:31:14Z

[Term]
id: GO:0061142
name: mesothelial-mesenchymal cell signaling involved in early lung development
namespace: biological_process
def: "Any process that mediates the transfer of information from a mesothelial cell to an epithelial cell and contributes to the development of the lung." [GOC:dph]
synonym: "mesothelial-mesenchymal cell signalling involved in early lung development" EXACT [GOC:mah]
is_a: GO:0060495 ! cell-cell signaling involved in lung development
created_by: dph
creation_date: 2010-05-25T09:35:32Z

[Term]
id: GO:0061143
name: alveolar primary septum development
namespace: biological_process
def: "The progression of a primary alveolar septum over time, from its formation to the mature structure. A primary alveolar septum is a specialized epithelium that surrounds the saccule as it forms." [GOC:dph]
is_a: GO:0060428 ! lung epithelium development
relationship: part_of GO:0060430 ! lung saccule development
created_by: dph
creation_date: 2010-05-25T10:21:27Z

[Term]
id: GO:0061144
name: alveolar secondary septum development
namespace: biological_process
def: "The progression of a secondary alveolar septum over time, from its formation to the mature structure. A secondary alveolar septum is a specialized epithelium that subdivides the initial saccule." [GOC:dph]
is_a: GO:0060428 ! lung epithelium development
relationship: part_of GO:0060430 ! lung saccule development
created_by: dph
creation_date: 2010-05-25T10:43:55Z

[Term]
id: GO:0061145
name: lung smooth muscle development
namespace: biological_process
def: "The process whose specific outcome is the progression of smooth muscle in the lung over time, from its formation to the mature structure." [GOC:dph]
is_a: GO:0048745 ! smooth muscle tissue development
relationship: part_of GO:0030324 ! lung development
created_by: dph
creation_date: 2010-05-25T10:46:35Z

[Term]
id: GO:0061146
name: Peyer's patch morphogenesis
namespace: biological_process
def: "The process in which a Peyer's patch is generated and organized. Peyer's patches are typically found as nodules associated with gut epithelium with distinct internal structures including B- and T-zones for the activation of lymphocytes." [GOC:dph]
is_a: GO:0048729 ! tissue morphogenesis
relationship: part_of GO:0048541 ! Peyer's patch development
created_by: dph
creation_date: 2010-05-26T06:46:23Z

[Term]
id: GO:0061147
name: endocardial endothelium development
namespace: biological_process
def: "The progression of the endocardial endothelium over time, from its initial formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:dph]
is_a: GO:0003158 ! endothelium development
relationship: part_of GO:0003157 ! endocardium development
created_by: dph
creation_date: 2010-06-03T09:15:31Z

[Term]
id: GO:0061148
name: extracellular matrix organization involved in endocardium development
namespace: biological_process
def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix of the endocardium. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:dph]
synonym: "extracellular matrix organisation involved in endocardium development" EXACT [GOC:mah]
is_a: GO:0030198 ! extracellular matrix organization
intersection_of: GO:0030198 ! extracellular matrix organization
intersection_of: part_of GO:0003157 ! endocardium development
relationship: part_of GO:0003157 ! endocardium development
created_by: dph
creation_date: 2010-06-03T09:18:02Z

[Term]
id: GO:0061149
name: BMP signaling pathway involved in ureter morphogenesis
namespace: biological_process
def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the shaping of the ureter. The ureter is a tube that extends from the kidney to the bladder." [GOC:dph, GOC:mtg_kidney_jan10]
synonym: "BMP signalling pathway involved in ureter morphogenesis" EXACT [GOC:mah]
is_a: GO:0030509 ! BMP signaling pathway
intersection_of: GO:0030509 ! BMP signaling pathway
intersection_of: part_of GO:0072197 ! ureter morphogenesis
relationship: part_of GO:0072197 ! ureter morphogenesis
created_by: dph
creation_date: 2010-06-02T09:11:46Z

[Term]
id: GO:0061150
name: renal system segmentation
namespace: biological_process
def: "The regionalization process that divides an the renal system into a series of segments along its proximal/distal axis." [GOC:dph, GOC:yaf]
synonym: "urinary tract segmentation" EXACT [GOC:dph]
is_a: GO:0035282 ! segmentation
is_a: GO:0072048 ! renal system pattern specification
created_by: dph
creation_date: 2010-06-02T09:23:01Z

[Term]
id: GO:0061151
name: BMP signaling pathway involved in renal system segmentation
namespace: biological_process
def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the segmentation of the renal system." [GOC:dph, GOC:yaf]
synonym: "BMP signalling pathway involved in renal system segmentation" EXACT [GOC:mah]
is_a: GO:0030509 ! BMP signaling pathway
intersection_of: GO:0030509 ! BMP signaling pathway
intersection_of: part_of GO:0061150 ! renal system segmentation
relationship: part_of GO:0061150 ! renal system segmentation
created_by: dph
creation_date: 2010-06-02T09:29:43Z

[Term]
id: GO:0061152
name: trachea submucosa development
namespace: biological_process
def: "The progression of the trachea submucosa over time from its formation to the mature structure. The trachea submucosa is made up of the glands and elastic tissue that lie under the mucosa in the trachea." [GOC:dph, GOC:yaf]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0060438 ! trachea development
created_by: dph
creation_date: 2010-06-07T09:58:40Z

[Term]
id: GO:0061153
name: trachea gland development
namespace: biological_process
def: "The progression of a trachea gland over time, from its formation to the mature structure. Trachea glands are found under the mucus of the trachea and secrete mucus, and agents that help protect the lung from injury and infection." [GOC:dph]
is_a: GO:0048732 ! gland development
relationship: part_of GO:0061152 ! trachea submucosa development
created_by: dph
creation_date: 2010-06-07T10:10:51Z

[Term]
id: GO:0061154
name: endothelial tube morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a tube are generated and organized from an endothelium. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells." [GOC:dph, GOC:yaf]
is_a: GO:0003159 ! morphogenesis of an endothelium
is_a: GO:0060562 ! epithelial tube morphogenesis
created_by: dph
creation_date: 2010-06-15T09:05:00Z

[Term]
id: GO:0061155
name: pulmonary artery endothelial tube morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a tube are generated and organized from the pulmonary artery endothelium. An pulmonary artery endothelium is an epithelium that lines the pulmonary artery." [GOC:dph, GOC:yaf]
is_a: GO:0061154 ! endothelial tube morphogenesis
relationship: part_of GO:0061156 ! pulmonary artery morphogenesis
created_by: dph
creation_date: 2010-06-15T09:09:04Z

[Term]
id: GO:0061156
name: pulmonary artery morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the pulmonary artery are generated and organized. The pulmonary artery is the artery that carries blood from the heart to the lungs." [GOC:dph, GOC:yaf]
is_a: GO:0048844 ! artery morphogenesis
created_by: dph
creation_date: 2010-06-15T09:13:47Z

[Term]
id: GO:0061157
name: mRNA destabilization
namespace: biological_process
def: "Any process that decreases the stability of an mRNA molecule, making it more vulnerable to degradative processes. Messenger RNA is the intermediate molecule between DNA and protein. It includes UTR and coding sequences. It does not contain introns." [GOC:dph, GOC:jh]
is_a: GO:0017148 ! negative regulation of translation
is_a: GO:0043488 ! regulation of mRNA stability
is_a: GO:0050779 ! RNA destabilization
created_by: dph
creation_date: 2010-06-22T08:42:10Z

[Term]
id: GO:0061158
name: 3'-UTR-mediated mRNA destabilization
namespace: biological_process
def: "An mRNA destabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA." [GOC:dph, GOC:jh]
is_a: GO:0061157 ! mRNA destabilization
created_by: dph
creation_date: 2010-06-22T08:44:39Z

[Term]
id: GO:0061159
name: establishment of bipolar cell polarity involved in cell morphogenesis
namespace: biological_process
def: "The specification and formation of bipolar intracellular organization or cell growth patterns that contribute to cell morphogenesis. Bipolar organization is the organization that is a mirror image along an axis from a plane." [GOC:dph, GOC:vw]
is_a: GO:0061171 ! establishment of bipolar cell polarity
intersection_of: GO:0061171 ! establishment of bipolar cell polarity
intersection_of: part_of GO:0000902 ! cell morphogenesis
relationship: part_of GO:0000902 ! cell morphogenesis
created_by: dph
creation_date: 2010-06-23T09:14:39Z

[Term]
id: GO:0061160
name: regulation of establishment of bipolar cell polarity regulating cell shape
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the establishment of bipolar cell polarity that contributes to the shape of a cell." [GOC:dph, GOC:vw]
is_a: GO:0061172 ! regulation of establishment of bipolar cell polarity
is_a: GO:2000100 ! regulation of establishment or maintenance of bipolar cell polarity regulating cell shape
created_by: dph
creation_date: 2010-06-23T09:21:36Z

[Term]
id: GO:0061161
name: positive regulation of establishment of bipolar cell polarity regulating cell shape
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the establishment of bipolar cell polarity that regulates the shape of a cell." [GOC:dph, GOC:vw]
is_a: GO:0061160 ! regulation of establishment of bipolar cell polarity regulating cell shape
is_a: GO:0061173 ! positive regulation of establishment of bipolar cell polarity
is_a: GO:2000247 ! positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape
created_by: dph
creation_date: 2010-06-23T09:26:45Z

[Term]
id: GO:0061162
name: establishment of monopolar cell polarity
namespace: biological_process
def: "The specification and formation of monopolar intracellular organization or cell growth patterns. Monopolar cell organization is directional organization along an axis." [GOC:dph, GOC:vw]
is_a: GO:0030010 ! establishment of cell polarity
is_a: GO:0061339 ! establishment or maintenance of monopolar cell polarity
created_by: dph
creation_date: 2010-06-23T09:30:59Z

[Term]
id: GO:0061163
name: endoplasmic reticulum polarization
namespace: biological_process
def: "The endoplasmic reticulum organization process that results in the structure of the endoplasmic reticulum being oriented in the cell." [GOC:dph, GOC:vw]
is_a: GO:0007029 ! endoplasmic reticulum organization
is_a: GO:0007163 ! establishment or maintenance of cell polarity
is_a: GO:1902589 ! single-organism organelle organization
created_by: dph
creation_date: 2010-06-25T09:51:48Z

[Term]
id: GO:0061164
name: transitional endoplasmic reticulum polarization at cell division site
namespace: biological_process
def: "The endoplasmic reticulum polarization process that results in the structure being polarized at the site of future cell division." [GOC:dph, GOC:vw]
is_a: GO:0061163 ! endoplasmic reticulum polarization
created_by: dph
creation_date: 2010-06-25T09:56:51Z

[Term]
id: GO:0061165
name: endoplasmic reticulum localization involved in endoplasmic reticulum polarization at cell division site
namespace: biological_process
def: "The process in which endoplasmic reticulum is transiently localized to the site where a cell will divide." [GOC:dph, GOC:vw]
synonym: "endoplasmic reticulum localisation involved in endoplasmic reticulum polarization at cell division site" EXACT [GOC:mah]
synonym: "ER localization involved in ER polarization at cell division site" EXACT [GOC:dph]
is_a: GO:0051643 ! endoplasmic reticulum localization
intersection_of: GO:0051643 ! endoplasmic reticulum localization
intersection_of: part_of GO:0061164 ! transitional endoplasmic reticulum polarization at cell division site
relationship: part_of GO:0061164 ! transitional endoplasmic reticulum polarization at cell division site
created_by: dph
creation_date: 2010-06-25T10:11:09Z

[Term]
id: GO:0061166
name: establishment of endoplasmic reticulum localization involved in endoplasmic reticulum polarization at cell division site
namespace: biological_process
def: "The directed movement of the endoplasmic reticulum to the site where a cell will divide." [GOC:dph, GOC:vw]
synonym: "establishment of endoplasmic reticulum localisation involved in endoplasmic reticulum polarization at cell division site" EXACT [GOC:mah]
is_a: GO:0051686 ! establishment of ER localization
is_a: GO:0061165 ! endoplasmic reticulum localization involved in endoplasmic reticulum polarization at cell division site
intersection_of: GO:0051686 ! establishment of ER localization
intersection_of: part_of GO:0061164 ! transitional endoplasmic reticulum polarization at cell division site
relationship: part_of GO:0061164 ! transitional endoplasmic reticulum polarization at cell division site
created_by: dph
creation_date: 2010-06-25T10:16:34Z

[Term]
id: GO:0061167
name: maintenance of endoplasmic reticulum location involved in endoplasmic reticulum polarization at cell division site
namespace: biological_process
def: "The process in which the endoplasmic reticulum is maintained at the site of cell division and is prevented from moving elsewhere." [GOC:dph, GOC:vw]
is_a: GO:0051685 ! maintenance of ER location
is_a: GO:0061165 ! endoplasmic reticulum localization involved in endoplasmic reticulum polarization at cell division site
intersection_of: GO:0051685 ! maintenance of ER location
intersection_of: part_of GO:0061164 ! transitional endoplasmic reticulum polarization at cell division site
relationship: part_of GO:0061164 ! transitional endoplasmic reticulum polarization at cell division site
created_by: dph
creation_date: 2010-06-25T10:18:36Z

[Term]
id: GO:0061168
name: regulation of hair follicle placode formation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of hair follicle placode formation, the developmental process in which a hair placode forms. An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud." [GOC:dph]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0051797 ! regulation of hair follicle development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060789 ! hair follicle placode formation
relationship: regulates GO:0060789 ! hair follicle placode formation
created_by: dph
creation_date: 2010-06-25T01:03:29Z

[Term]
id: GO:0061169
name: positive regulation of hair placode formation
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of hair follicle placode formation, the developmental process in which a hair placode forms. An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud." [GOC:dph]
is_a: GO:0051798 ! positive regulation of hair follicle development
is_a: GO:0061168 ! regulation of hair follicle placode formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060789 ! hair follicle placode formation
relationship: positively_regulates GO:0060789 ! hair follicle placode formation
created_by: dph
creation_date: 2010-06-25T01:08:50Z

[Term]
id: GO:0061170
name: negative regulation of hair follicle placode formation
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of hair follicle placode formation, the developmental process in which a hair placode forms. An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud." [GOC:dph]
is_a: GO:0051799 ! negative regulation of hair follicle development
is_a: GO:0061168 ! regulation of hair follicle placode formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060789 ! hair follicle placode formation
relationship: negatively_regulates GO:0060789 ! hair follicle placode formation
created_by: dph
creation_date: 2010-06-25T01:10:48Z

[Term]
id: GO:0061171
name: establishment of bipolar cell polarity
namespace: biological_process
def: "The specification and formation of bipolar intracellular organization or cell growth patterns. Bipolar organization is the organization that is a mirror image along an axis from a plane." [GOC:dph, GOC:vw]
is_a: GO:0030010 ! establishment of cell polarity
created_by: dph
creation_date: 2010-06-30T08:49:38Z

[Term]
id: GO:0061172
name: regulation of establishment of bipolar cell polarity
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the establishment of bipolar cell polarity. Bipolar organization is the organization that is a mirror image along an axis from a plane." [GOC:dph, GOC:vw]
is_a: GO:2000114 ! regulation of establishment of cell polarity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061171 ! establishment of bipolar cell polarity
relationship: regulates GO:0061171 ! establishment of bipolar cell polarity
created_by: dph
creation_date: 2010-06-30T08:51:27Z

[Term]
id: GO:0061173
name: positive regulation of establishment of bipolar cell polarity
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the establishment of bipolar cell polarity." [GOC:dph, GOC:vw]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0061172 ! regulation of establishment of bipolar cell polarity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061171 ! establishment of bipolar cell polarity
relationship: positively_regulates GO:0061171 ! establishment of bipolar cell polarity
created_by: dph
creation_date: 2010-06-30T08:59:20Z

[Term]
id: GO:0061174
name: type I terminal bouton
namespace: cellular_component
def: "Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary to release neurotransmitters that will induce the contraction of muscle. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc]
synonym: "type I terminal button" EXACT [GOC:dph]
is_a: GO:0043195 ! terminal bouton
created_by: dph
creation_date: 2010-07-13T09:13:05Z

[Term]
id: GO:0061175
name: type II terminal bouton
namespace: cellular_component
def: "Terminal inflated portion of the axon of a non-glutamatergic neuron, containing the specialized apparatus necessary to release neurotransmitters at a regulatory synapse. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc]
synonym: "type II terminal button" EXACT [GOC:dph]
is_a: GO:0043195 ! terminal bouton
created_by: dph
creation_date: 2010-07-13T09:18:01Z

[Term]
id: GO:0061176
name: type Ib terminal bouton
namespace: cellular_component
def: "Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary for the tonic release neurotransmitters that will induce the contraction of muscle. Type Ib terminal boutons are larger than type Is terminal boutons." [GOC:dph, GOC:mc]
synonym: "type Ib terminal button" EXACT [GOC:dph]
is_a: GO:0061174 ! type I terminal bouton
created_by: dph
creation_date: 2010-07-13T09:20:04Z

[Term]
id: GO:0061177
name: type Is terminal bouton
namespace: cellular_component
def: "Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary for the phasic release neurotransmitters that will induce the contraction of muscle. Type Is terminal boutons are smaller than type Ib terminal boutons." [GOC:dph, GOC:mc]
synonym: "type Is terminal button" RELATED [GOC:dph]
is_a: GO:0061174 ! type I terminal bouton
created_by: dph
creation_date: 2010-07-13T09:25:15Z

[Term]
id: GO:0061178
name: regulation of insulin secretion involved in cellular response to glucose stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose." [GOC:BHF, GOC:dph]
synonym: "regulation of insulin secretion in response to glucose" EXACT [GOC:dph]
is_a: GO:0032844 ! regulation of homeostatic process
is_a: GO:0048583 ! regulation of response to stimulus
is_a: GO:0050796 ! regulation of insulin secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035773 ! insulin secretion involved in cellular response to glucose stimulus
relationship: regulates GO:0035773 ! insulin secretion involved in cellular response to glucose stimulus
created_by: dph
creation_date: 2010-07-13T09:38:42Z

[Term]
id: GO:0061179
name: negative regulation of insulin secretion involved in cellular response to glucose stimulus
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose." [GOC:BHF, GOC:dph]
synonym: "negative regulation of insulin secretion in response to glucose" RELATED [GOC:dph]
synonym: "negative regulation of insulin secretion involved in cellular response to glucose" EXACT [GOC:bf]
is_a: GO:0032845 ! negative regulation of homeostatic process
is_a: GO:0046676 ! negative regulation of insulin secretion
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:0061178 ! regulation of insulin secretion involved in cellular response to glucose stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035773 ! insulin secretion involved in cellular response to glucose stimulus
relationship: negatively_regulates GO:0035773 ! insulin secretion involved in cellular response to glucose stimulus
created_by: dph
creation_date: 2010-07-13T09:41:46Z

[Term]
id: GO:0061180
name: mammary gland epithelium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the mammary gland epithelium over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk." [GOC:dph, GOC:yaf]
synonym: "breast epithelium development" EXACT [GOC:dph]
is_a: GO:0060429 ! epithelium development
relationship: part_of GO:0030879 ! mammary gland development
created_by: dph
creation_date: 2010-07-14T08:18:24Z

[Term]
id: GO:0061181
name: regulation of chondrocyte development
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate." [GOC:BHF, GOC:dph]
is_a: GO:0032330 ! regulation of chondrocyte differentiation
is_a: GO:0060284 ! regulation of cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002063 ! chondrocyte development
relationship: regulates GO:0002063 ! chondrocyte development
created_by: dph
creation_date: 2010-07-14T08:28:52Z

[Term]
id: GO:0061182
name: negative regulation of chondrocyte development
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate." [GOC:BHF, GOC:dph]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0032331 ! negative regulation of chondrocyte differentiation
is_a: GO:0061181 ! regulation of chondrocyte development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002063 ! chondrocyte development
relationship: negatively_regulates GO:0002063 ! chondrocyte development
created_by: dph
creation_date: 2010-07-14T08:33:05Z

[Term]
id: GO:0061183
name: regulation of dermatome development
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin." [GOC:BHF, GOC:dph]
is_a: GO:0045995 ! regulation of embryonic development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061054 ! dermatome development
relationship: regulates GO:0061054 ! dermatome development
created_by: dph
creation_date: 2010-07-14T08:40:26Z

[Term]
id: GO:0061184
name: positive regulation of dermatome development
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin." [GOC:BHF, GOC:dph]
is_a: GO:0040019 ! positive regulation of embryonic development
is_a: GO:0061183 ! regulation of dermatome development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061054 ! dermatome development
relationship: positively_regulates GO:0061054 ! dermatome development
created_by: dph
creation_date: 2010-07-14T08:42:03Z

[Term]
id: GO:0061185
name: negative regulation of dermatome development
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin." [GOC:BHF, GOC:dph]
is_a: GO:0045992 ! negative regulation of embryonic development
is_a: GO:0061183 ! regulation of dermatome development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061054 ! dermatome development
relationship: negatively_regulates GO:0061054 ! dermatome development
created_by: dph
creation_date: 2010-07-14T08:43:08Z

[Term]
id: GO:0061186
name: negative regulation of chromatin silencing at silent mating-type cassette
namespace: biological_process
def: "Any process that decreases the frequency, rate, or extent of chromatin silencing at silent mating-type cassette. Chromatin silencing at silent mating-type cassette is the repression of transcription at silent mating-type loci by altering the structure of chromatin." [GOC:dph, PMID:10388812]
is_a: GO:0031936 ! negative regulation of chromatin silencing
is_a: GO:0090054 ! regulation of chromatin silencing at silent mating-type cassette
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030466 ! chromatin silencing at silent mating-type cassette
relationship: negatively_regulates GO:0030466 ! chromatin silencing at silent mating-type cassette
created_by: dph
creation_date: 2010-07-14T08:59:11Z

[Term]
id: GO:0061187
name: regulation of chromatin silencing at rDNA
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the repression of transcription of ribosomal DNA by altering the structure of chromatin." [GOC:dph, PMID:10388812]
is_a: GO:0031935 ! regulation of chromatin silencing
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000183 ! chromatin silencing at rDNA
relationship: regulates GO:0000183 ! chromatin silencing at rDNA
created_by: dph
creation_date: 2010-07-14T09:04:16Z

[Term]
id: GO:0061188
name: negative regulation of chromatin silencing at rDNA
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the repression of transcription of ribosomal DNA by altering the structure of chromatin." [GOC:dph, PMID:10388812]
is_a: GO:0031936 ! negative regulation of chromatin silencing
is_a: GO:0061187 ! regulation of chromatin silencing at rDNA
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000183 ! chromatin silencing at rDNA
relationship: negatively_regulates GO:0000183 ! chromatin silencing at rDNA
created_by: dph
creation_date: 2010-07-14T09:07:59Z

[Term]
id: GO:0061189
name: positive regulation of sclerotome development
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra." [GOC:BHF, GOC:dph]
is_a: GO:0040019 ! positive regulation of embryonic development
is_a: GO:0061190 ! regulation of sclerotome development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061056 ! sclerotome development
relationship: positively_regulates GO:0061056 ! sclerotome development
created_by: dph
creation_date: 2010-07-14T09:17:23Z

[Term]
id: GO:0061190
name: regulation of sclerotome development
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra." [GOC:dph]
is_a: GO:0045995 ! regulation of embryonic development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061056 ! sclerotome development
relationship: regulates GO:0061056 ! sclerotome development
created_by: dph
creation_date: 2010-07-14T09:19:47Z

[Term]
id: GO:0061191
name: positive regulation of vacuole fusion, non-autophagic
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the fusion of two vacuole membranes to form a single vacuole." [GOC:dph]
is_a: GO:0032889 ! regulation of vacuole fusion, non-autophagic
is_a: GO:0044090 ! positive regulation of vacuole organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042144 ! vacuole fusion, non-autophagic
relationship: positively_regulates GO:0042144 ! vacuole fusion, non-autophagic
created_by: dph
creation_date: 2010-07-14T09:33:31Z

[Term]
id: GO:0061192
name: negative regulation of vacuole fusion, non-autophagic
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the fusion of two vacuole membranes to form a single vacuole." [GOC:dph]
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:0032889 ! regulation of vacuole fusion, non-autophagic
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042144 ! vacuole fusion, non-autophagic
relationship: negatively_regulates GO:0042144 ! vacuole fusion, non-autophagic
created_by: dph
creation_date: 2010-07-14T09:35:18Z

[Term]
id: GO:0061193
name: taste bud development
namespace: biological_process
def: "The progression of the taste bud over time, from its formation to the mature state. The taste bud is a specialized area of the tongue that contains taste receptors." [GOC:dph]
is_a: GO:0007423 ! sensory organ development
relationship: part_of GO:0043586 ! tongue development
created_by: dph
creation_date: 2010-07-27T10:55:08Z

[Term]
id: GO:0061194
name: taste bud morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the taste bud are generated and organized. The taste bud is a specialized area of the tongue that contains taste receptors." [GOC:dph]
is_a: GO:0090596 ! sensory organ morphogenesis
relationship: part_of GO:0043587 ! tongue morphogenesis
relationship: part_of GO:0061193 ! taste bud development
created_by: dph
creation_date: 2010-07-27T11:01:31Z

[Term]
id: GO:0061195
name: taste bud formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the taste bud from unspecified parts. The taste bud is a specialized area of the tongue that contains taste receptors." [GOC:dph]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0061194 ! taste bud morphogenesis
created_by: dph
creation_date: 2010-07-27T12:22:26Z

[Term]
id: GO:0061196
name: fungiform papilla development
namespace: biological_process
def: "The progression of the fungiform papilla over time, from its formation to the mature structure. The fungiform papilla is a mushroom-shaped papilla of the tongue." [GOC:dph]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0043586 ! tongue development
created_by: dph
creation_date: 2010-07-27T12:23:48Z

[Term]
id: GO:0061197
name: fungiform papilla morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the fungiform papilla are generated and organized. The fungiform papilla is a mushroom-shaped papilla of the tongue." [GOC:dph]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0043587 ! tongue morphogenesis
relationship: part_of GO:0061196 ! fungiform papilla development
created_by: dph
creation_date: 2010-07-27T12:26:40Z

[Term]
id: GO:0061198
name: fungiform papilla formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a spongiform papilla from unspecified parts. The fungiform papilla is a mushroom-shaped papilla of the tongue." [GOC:dph]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0061197 ! fungiform papilla morphogenesis
created_by: dph
creation_date: 2010-07-27T12:29:03Z

[Term]
id: GO:0061199
name: striated muscle contraction involved in embryonic body morphogenesis
namespace: biological_process
def: "The process in which force is generated within striated embryonic muscle tissue, resulting in a contraction of the muscle that contributes to the formation of an embryo's characteristic body morphology." [GOC:dph, GOC:kmv]
is_a: GO:0006941 ! striated muscle contraction
intersection_of: GO:0006941 ! striated muscle contraction
intersection_of: part_of GO:0010172 ! embryonic body morphogenesis
relationship: part_of GO:0010172 ! embryonic body morphogenesis
created_by: dph
creation_date: 2010-07-28T04:07:23Z

[Term]
id: GO:0061200
name: clathrin-sculpted gamma-aminobutyric acid transport vesicle
namespace: cellular_component
def: "A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing gamma-aminobutyric acid transport vesicle." [GOC:dph]
synonym: "clathrin sculpted GABA transport vesicle" EXACT [GOC:dph]
synonym: "clathrin sculpted gamma-aminobutyric acid transport vesicle" EXACT [GOC:sl]
is_a: GO:0060198 ! clathrin-sculpted vesicle
created_by: dph
creation_date: 2010-07-29T10:40:43Z

[Term]
id: GO:0061201
name: clathrin-sculpted gamma-aminobutyric acid transport vesicle lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of the clathrin-sculpted gamma-aminobutyric acid transport vesicle." [GOC:dph]
synonym: "clathrin sculpted GABA transport vesicle lumen" EXACT [GOC:dph]
synonym: "clathrin sculpted gamma-aminobutyric acid transport vesicle lumen" EXACT [GOC:sl]
is_a: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen
relationship: part_of GO:0061200 ! clathrin-sculpted gamma-aminobutyric acid transport vesicle
created_by: dph
creation_date: 2010-07-29T10:45:05Z

[Term]
id: GO:0061202
name: clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a clathrin-sculpted gamma-aminobutyric acid transport vesicle." [GOC:dph]
synonym: "clathrin sculpted GABA transport vesicle membrane" EXACT [GOC:dph]
synonym: "clathrin sculpted gamma-aminobutyric acid transport vesicle membrane" EXACT [GOC:sl]
is_a: GO:0030665 ! clathrin-coated vesicle membrane
relationship: part_of GO:0061200 ! clathrin-sculpted gamma-aminobutyric acid transport vesicle
created_by: dph
creation_date: 2010-07-29T10:54:33Z

[Term]
id: GO:0061203
name: striated muscle paramyosin thick filament assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins to form the paramyosin-based thick filaments of myofibrils in striated muscle." [GOC:dph, GOC:kmv]
is_a: GO:0061204 ! paramyosin filament assembly or disassembly
relationship: part_of GO:0030239 ! myofibril assembly
created_by: dph
creation_date: 2010-07-29T12:22:31Z

[Term]
id: GO:0061204
name: paramyosin filament assembly or disassembly
namespace: biological_process
def: "The formation or disassembly of a filament composed of paramyosin molecules." [GOC:dph, GOC:kmv]
is_a: GO:0030036 ! actin cytoskeleton organization
created_by: dph
creation_date: 2010-07-29T12:26:38Z

[Term]
id: GO:0061205
name: paramesonephric duct development
namespace: biological_process
def: "The process whose specific outcome is the progression of the paramesonephric duct over time, from its formation to the mature structure. Mullerian ducts (or paramesonephric ducts) are paired ducts of the embryo that run down the lateral sides of the urogenital ridge and terminate at the mullerian eminence in the primitive urogenital sinus. In the female, they will develop to form the fallopian tubes, uterus, cervix, and the upper portion of the vagina; in the male, they are lost. These ducts are made of tissue of mesodermal origin." [GOC:dph, GOC:yaf]
synonym: "Mullerian duct development" EXACT [GOC:dph]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0035295 ! tube development
created_by: dph
creation_date: 2010-07-30T10:54:47Z

[Term]
id: GO:0061206
name: mesonephros morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the mesonephros are generated and organized." [GOC:mtg_kidney_jan10]
synonym: "Wolffian body morphogenesis" EXACT [GOC:dph]
is_a: GO:0060993 ! kidney morphogenesis
relationship: part_of GO:0001823 ! mesonephros development
created_by: dph
creation_date: 2010-08-17T03:11:10Z

[Term]
id: GO:0061207
name: mesonephric juxtaglomerulus cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the juxtaglomerulus cells of the mesonephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
is_a: GO:0061208 ! cell differentiation involved in mesonephros development
is_a: GO:0072052 ! juxtaglomerulus cell differentiation
relationship: part_of GO:0061212 ! mesonephric juxtaglomerular apparatus development
created_by: dph
creation_date: 2010-08-19T12:54:08Z

[Term]
id: GO:0061208
name: cell differentiation involved in mesonephros development
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the mesonephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
is_a: GO:0061005 ! cell differentiation involved in kidney development
intersection_of: GO:0030154 ! cell differentiation
intersection_of: part_of GO:0001823 ! mesonephros development
relationship: part_of GO:0001823 ! mesonephros development
created_by: dph
creation_date: 2010-08-17T03:21:23Z

[Term]
id: GO:0061209
name: cell proliferation involved in mesonephros development
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of the population in the mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072111 ! cell proliferation involved in kidney development
intersection_of: GO:0008283 ! cell proliferation
intersection_of: part_of GO:0001823 ! mesonephros development
relationship: part_of GO:0001823 ! mesonephros development
created_by: dph
creation_date: 2010-08-17T03:22:46Z

[Term]
id: GO:0061210
name: cell-cell signaling involved in mesonephros development
namespace: biological_process
def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the mesonephros over time, from its formation to the mature organ." [GOC:mtg_kidney_jan10]
synonym: "cell-cell signalling involved in mesonephros development" EXACT [GOC:mah]
is_a: GO:0060995 ! cell-cell signaling involved in kidney development
intersection_of: GO:0007267 ! cell-cell signaling
intersection_of: part_of GO:0001823 ! mesonephros development
relationship: part_of GO:0001823 ! mesonephros development
created_by: dph
creation_date: 2010-08-17T03:24:08Z

[Term]
id: GO:0061211
name: mesonephric collecting duct development
namespace: biological_process
def: "The process whose specific outcome is the progression of a collecting duct in the mesonephros over time, from its formation to the mature structure. The collecting duct regulates water, electrolyte and acid-base balance. The collecting duct is the final common path through which urine flows before entering the ureter and then emptying into the bladder." [GOC:mtg_kidney_jan10]
is_a: GO:0072044 ! collecting duct development
relationship: part_of GO:0001823 ! mesonephros development
created_by: dph
creation_date: 2010-08-17T03:25:51Z

[Term]
id: GO:0061212
name: mesonephric juxtaglomerular apparatus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the juxtaglomerular apparatus in the mesonephros over time, from its formation to the mature structure. The juxtaglomerular apparatus is an anatomical structure which consists of juxtaglomerular cells, extraglomerular mesangial cells and the macula densa. The juxtaglomerular apparatus lies adjacent to the glomerulus and regulates kidney function by maintaining the blood flow to the kidney and the filtration rate." [GOC:mtg_kidney_jan10]
is_a: GO:0072051 ! juxtaglomerular apparatus development
relationship: part_of GO:0001823 ! mesonephros development
created_by: dph
creation_date: 2010-08-17T03:27:36Z

[Term]
id: GO:0061213
name: positive regulation of mesonephros development
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of mesonephros development. Mesonephros development is the process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. The mesonephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:mtg_kidney_jan10]
is_a: GO:0061217 ! regulation of mesonephros development
is_a: GO:0090184 ! positive regulation of kidney development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001823 ! mesonephros development
relationship: positively_regulates GO:0001823 ! mesonephros development
created_by: dph
creation_date: 2010-08-17T03:39:35Z

[Term]
id: GO:0061214
name: mesonephric smooth muscle tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of smooth muscle in the mesonephros over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10]
is_a: GO:0072194 ! kidney smooth muscle tissue development
relationship: part_of GO:0001823 ! mesonephros development
created_by: dph
creation_date: 2010-08-17T03:29:54Z

[Term]
id: GO:0061215
name: mesonephric nephron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a nephron in the mesonephros over time, from its formation to the mature structure. A nephron is the functional unit of the kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0072006 ! nephron development
relationship: part_of GO:0001823 ! mesonephros development
created_by: dph
creation_date: 2010-08-17T03:31:08Z

[Term]
id: GO:0061216
name: regulation of transcription from RNA polymerase II promoter involved in mesonephros development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the mesonephros progressing from its initial formation to the mature state." [GOC:mtg_kidney_jan10]
is_a: GO:0060994 ! regulation of transcription from RNA polymerase II promoter involved in kidney development
intersection_of: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
intersection_of: part_of GO:0001823 ! mesonephros development
relationship: part_of GO:0001823 ! mesonephros development
created_by: dph
creation_date: 2010-08-17T03:32:27Z

[Term]
id: GO:0061217
name: regulation of mesonephros development
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of mesonephros development. Mesonephros development is the process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. The mesonephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:mtg_kidney_jan10]
is_a: GO:0090183 ! regulation of kidney development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001823 ! mesonephros development
relationship: regulates GO:0001823 ! mesonephros development
created_by: dph
creation_date: 2010-08-17T03:35:31Z

[Term]
id: GO:0061218
name: negative regulation of mesonephros development
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of mesonephros development. Mesonephros development is the process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. The mesonephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:mtg_kidney_jan10]
is_a: GO:0061217 ! regulation of mesonephros development
is_a: GO:0090185 ! negative regulation of kidney development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001823 ! mesonephros development
relationship: negatively_regulates GO:0001823 ! mesonephros development
created_by: dph
creation_date: 2010-08-17T03:43:06Z

[Term]
id: GO:0061219
name: mesonephric mesenchyme development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a mesonephric mesenchyme from an initial condition to its mature state. This process begins with the formation of mesonephric mesenchyme and ends with the mature structure. Mesonephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072074 ! kidney mesenchyme development
relationship: part_of GO:0001823 ! mesonephros development
created_by: dph
creation_date: 2010-08-17T03:45:44Z

[Term]
id: GO:0061220
name: mesonephric macula densa development
namespace: biological_process
def: "The process whose specific outcome is the progression of the mesonephric macula densa over time, from its formation to the mature structure. The mesonephric macula densa is an area of specialized cells in the distal tubule of the mesonephros that makes contact with the vascular pole of the glomerulus." [GOC:mtg_kidney_jan10]
is_a: GO:0061241 ! mesonephric nephron epithelium development
is_a: GO:0072024 ! macula densa development
relationship: part_of GO:0061212 ! mesonephric juxtaglomerular apparatus development
created_by: dph
creation_date: 2010-08-19T01:11:41Z

[Term]
id: GO:0061221
name: mesonephric mesenchyme morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a mesonephric mesenchymal tissue are generated and organized. Mesonephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072131 ! kidney mesenchyme morphogenesis
relationship: part_of GO:0061219 ! mesonephric mesenchyme development
created_by: dph
creation_date: 2010-08-19T01:17:38Z

[Term]
id: GO:0061222
name: mesonephric mesenchymal cell proliferation involved in mesonephros development
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a mesonephric mesenchymal cell population." [GOC:mtg_kidney_jan10]
is_a: GO:0061209 ! cell proliferation involved in mesonephros development
is_a: GO:0072135 ! kidney mesenchymal cell proliferation
relationship: part_of GO:0061219 ! mesonephric mesenchyme development
created_by: dph
creation_date: 2010-08-19T01:20:14Z

[Term]
id: GO:0061223
name: mesonephric mesenchymal cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the mesonephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
is_a: GO:0061208 ! cell differentiation involved in mesonephros development
is_a: GO:0072161 ! mesenchymal cell differentiation involved in kidney development
relationship: part_of GO:0061219 ! mesonephric mesenchyme development
created_by: dph
creation_date: 2010-08-19T01:21:48Z

[Term]
id: GO:0061224
name: mesonephric glomerulus development
namespace: biological_process
def: "The progression of the mesonephric glomerulus over time from its initial formation until its mature state. The mesonephric glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the mature vertebrate kidney, or mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0032835 ! glomerulus development
relationship: part_of GO:0061215 ! mesonephric nephron development
created_by: dph
creation_date: 2010-08-19T01:26:00Z

[Term]
id: GO:0061225
name: mesonephric extraglomerular mesangial cell proliferation involved in mesonephros development
namespace: biological_process
def: "The multiplication or reproduction of extraglomerular glomerular mesangium cells in the mesonephros by cell division, resulting in the expansion of their population. Extraglomerular mesangial cells (also known as lacis cells, Goormaghtigh cells) are light-staining cells in the kidney found outside the glomerulus, near the vascular pole and macula densa." [GOC:mtg_kidney_jan10]
synonym: "mesonephric Goormaghtigh proliferation" RELATED [GOC:mtg_kidney_jan10]
synonym: "mesonephric lacis cell proliferation" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0061209 ! cell proliferation involved in mesonephros development
is_a: GO:0072122 ! extraglomerular mesangial cell proliferation
relationship: part_of GO:0061215 ! mesonephric nephron development
created_by: dph
creation_date: 2010-08-19T01:34:59Z

[Term]
id: GO:0061226
name: proximal/distal pattern formation involved in mesonephric nephron development
namespace: biological_process
def: "The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis of a nephron in the mesonephros. The proximal/distal axis is defined by a line that runs from the glomerulus (proximal end) outward toward the mesonephric duct (distal end)." [GOC:mtg_kidney_jan10]
is_a: GO:0061227 ! pattern specification involved in mesonephros development
is_a: GO:0072047 ! proximal/distal pattern formation involved in nephron development
relationship: part_of GO:0061215 ! mesonephric nephron development
created_by: dph
creation_date: 2010-08-19T02:10:25Z

[Term]
id: GO:0061227
name: pattern specification involved in mesonephros development
namespace: biological_process
def: "Any developmental process that results in the creation of defined areas or spaces within the mesonephros to which cells respond and eventually are instructed to differentiate." [GOC:mtg_kidney_jan10]
synonym: "mesonephros pattern formation" RELATED [GOC:mtg_kidney_jan10]
synonym: "mesonephros pattern specification" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0061004 ! pattern specification involved in kidney development
intersection_of: GO:0007389 ! pattern specification process
intersection_of: part_of GO:0001823 ! mesonephros development
relationship: part_of GO:0001823 ! mesonephros development
created_by: dph
creation_date: 2010-08-19T02:22:22Z

[Term]
id: GO:0061228
name: mesonephric nephron morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the mesonephric nephron are generated and organized. A mesonephric nephron is the functional unit of the mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072028 ! nephron morphogenesis
relationship: part_of GO:0061206 ! mesonephros morphogenesis
relationship: part_of GO:0061215 ! mesonephric nephron development
created_by: dph
creation_date: 2010-08-19T02:26:24Z

[Term]
id: GO:0061229
name: mesonephric juxtaglomerulus cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a mesonephric juxtaglomerulus cell over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10]
is_a: GO:0072142 ! juxtaglomerulus cell development
relationship: part_of GO:0061207 ! mesonephric juxtaglomerulus cell differentiation
created_by: dph
creation_date: 2010-08-19T02:34:25Z

[Term]
id: GO:0061230
name: mesonephric juxtaglomerulus cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric juxtaglomerulus cell." [GOC:mtg_kidney_jan10]
is_a: GO:0072150 ! juxtaglomerulus cell fate commitment
relationship: part_of GO:0061207 ! mesonephric juxtaglomerulus cell differentiation
created_by: dph
creation_date: 2010-08-19T02:36:23Z

[Term]
id: GO:0061231
name: mesonephric glomerulus vasculature development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a mesonephric glomerulus vasculature from an initial condition to its mature state. This process begins with the formation of the mesonephric glomerulus vasculature and ends with the mature structure. The mesonephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the mesonephric glomerulus." [GOC:mtg_kidney_jan10]
is_a: GO:0072012 ! glomerulus vasculature development
relationship: part_of GO:0061224 ! mesonephric glomerulus development
created_by: dph
creation_date: 2010-08-19T02:47:06Z

[Term]
id: GO:0061232
name: mesonephric glomerular epithelium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the mesonephric glomerular epithelium over time, from its formation to the mature structure. The mesonephric glomerular epithelium is an epithelial tissue that covers the outer surfaces of the glomerulus in the mesonephros. The mesonephric glomerular epithelium consists of both parietal and visceral epithelium. Mesonephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains \\\"feet\\\" that interdigitate with the \\\"feet\\\" of other glomerular epithelial cells in the mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0061241 ! mesonephric nephron epithelium development
is_a: GO:0072010 ! glomerular epithelium development
relationship: part_of GO:0061224 ! mesonephric glomerulus development
created_by: dph
creation_date: 2010-08-19T02:49:46Z

[Term]
id: GO:0061233
name: mesonephric glomerular basement membrane development
namespace: biological_process
def: "The process whose specific outcome is the progression of the mesonephric glomerular basement membrane over time, from its formation to the mature structure. The mesonephric glomerular basement membrane is the basal laminal portion of the mesonephric glomerulus which performs the actual filtration." [GOC:mtg_kidney_jan10]
is_a: GO:0032836 ! glomerular basement membrane development
relationship: part_of GO:0061224 ! mesonephric glomerulus development
created_by: dph
creation_date: 2010-08-19T02:52:18Z

[Term]
id: GO:0061234
name: mesonephric glomerulus morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the mesonephric glomerulus are generated and organized. The mesonephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072102 ! glomerulus morphogenesis
relationship: part_of GO:0061224 ! mesonephric glomerulus development
relationship: part_of GO:0061228 ! mesonephric nephron morphogenesis
created_by: dph
creation_date: 2010-08-19T02:53:35Z

[Term]
id: GO:0061235
name: mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis
namespace: biological_process
def: "The process in which an organism retains a population of mesenchymal stem cells that contributes to the shaping of a nephron in the mesonephros. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [GOC:mtg_kidney_jan10]
is_a: GO:0072038 ! mesenchymal stem cell maintenance involved in nephron morphogenesis
relationship: part_of GO:0061228 ! mesonephric nephron morphogenesis
created_by: dph
creation_date: 2010-08-19T02:57:11Z

[Term]
id: GO:0061236
name: mesonephric comma-shaped body morphogenesis
namespace: biological_process
def: "The process in which the mesonephric comma-shaped body is generated and organized. The mesonephric comma-shaped body is the precursor structure to the mesonephric S-shaped body that contributes to the morphogenesis of a nephron in the mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072049 ! comma-shaped body morphogenesis
relationship: part_of GO:0061228 ! mesonephric nephron morphogenesis
created_by: dph
creation_date: 2010-08-19T03:00:21Z

[Term]
id: GO:0061237
name: convergent extension involved in mesonephric nephron morphogenesis
namespace: biological_process
def: "The morphogenetic process in which the renal epithelium narrows along one axis and lengthens in a perpendicular axis that contributes to the shaping of a nephron in the mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072045 ! convergent extension involved in nephron morphogenesis
intersection_of: GO:0060026 ! convergent extension
intersection_of: part_of GO:0061228 ! mesonephric nephron morphogenesis
relationship: part_of GO:0061228 ! mesonephric nephron morphogenesis
created_by: dph
creation_date: 2010-08-19T03:02:44Z

[Term]
id: GO:0061238
name: establishment of planar polarity involved in mesonephric nephron morphogenesis
namespace: biological_process
def: "Coordinated organization of groups of cells in the plane of an epithelium that contributes to the shaping of a nephron in the mesonephros." [GOC:mtg_kidney_jan10]
synonym: "establishment of planar cell polarity involved in mesonephric nephron morphogenesis" NARROW [GOC:mtg_kidney_jan10]
is_a: GO:0072046 ! establishment of planar polarity involved in nephron morphogenesis
intersection_of: GO:0001736 ! establishment of planar polarity
intersection_of: part_of GO:0061228 ! mesonephric nephron morphogenesis
relationship: part_of GO:0061228 ! mesonephric nephron morphogenesis
created_by: dph
creation_date: 2010-08-19T03:04:40Z

[Term]
id: GO:0061239
name: mesenchymal stem cell differentiation involved in mesonephric nephron morphogenesis
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal stem cell that contributes to the shaping of a nephronin the mesonephros. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [GOC:mtg_kidney_jan10]
is_a: GO:0061208 ! cell differentiation involved in mesonephros development
is_a: GO:0072037 ! mesenchymal stem cell differentiation involved in nephron morphogenesis
relationship: part_of GO:0061228 ! mesonephric nephron morphogenesis
created_by: dph
creation_date: 2010-08-19T03:06:46Z

[Term]
id: GO:0061240
name: mesonephric nephron tubule morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a mesonephric nephron tubule are generated and organized. A mesonephric nephron tubule is an epithelial tube that is part of the mesonephric nephron, the functional part of the mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072171 ! mesonephric tubule morphogenesis
relationship: part_of GO:0061228 ! mesonephric nephron morphogenesis
relationship: part_of GO:0061242 ! mesonephric nephron tubule development
created_by: dph
creation_date: 2010-08-19T03:09:26Z

[Term]
id: GO:0061241
name: mesonephric nephron epithelium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the mesonephric nephron epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The mesonephric nephron epithelium is a tissue that covers the surface of a nephron in the mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072009 ! nephron epithelium development
is_a: GO:0072163 ! mesonephric epithelium development
relationship: part_of GO:0061215 ! mesonephric nephron development
created_by: dph
creation_date: 2010-08-19T03:11:59Z

[Term]
id: GO:0061242
name: mesonephric nephron tubule development
namespace: biological_process
def: "The progression of a mesonephric nephron tubule over time, from its initial formation to the mature structure. A mesonephric nephron tubule is an epithelial tube that is part of the mesonephric nephron, the functional part of the mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0061241 ! mesonephric nephron epithelium development
is_a: GO:0072080 ! nephron tubule development
is_a: GO:0072164 ! mesonephric tubule development
created_by: dph
creation_date: 2010-08-19T03:17:00Z

[Term]
id: GO:0061243
name: mesonephric renal vesicle morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the mesonephric renal vesicle are generated and organized. The renal vesicle is the primordial structure of the mesonephric nephron epithelium, and is formed by the condensation of mesenchymal cells." [GOC:mtg_kidney_jan10]
is_a: GO:0072077 ! renal vesicle morphogenesis
relationship: part_of GO:0061228 ! mesonephric nephron morphogenesis
created_by: dph
creation_date: 2010-08-19T03:20:21Z

[Term]
id: GO:0061244
name: mesonephric S-shaped body morphogenesis
namespace: biological_process
def: "The process in which the mesonephric S-shaped body is generated and organized. The mesonephric S-shaped body is the successor of the mesonephric comma-shaped body that contributes to the morphogenesis of a nephron in the mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072050 ! S-shaped body morphogenesis
relationship: part_of GO:0061228 ! mesonephric nephron morphogenesis
created_by: dph
creation_date: 2010-08-19T03:23:55Z

[Term]
id: GO:0061245
name: establishment or maintenance of bipolar cell polarity
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of a bipolar intracellular organization or cell growth patterns." [GOC:dph, GOC:vw]
is_a: GO:0007163 ! establishment or maintenance of cell polarity
created_by: dph
creation_date: 2010-08-23T09:42:05Z

[Term]
id: GO:0061246
name: establishment or maintenance of bipolar cell polarity regulating cell shape
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of a bipolar intracellular organization or cell growth patterns that regulates the shaping of a cell." [GOC:dph, GOC:vw]
is_a: GO:0061245 ! establishment or maintenance of bipolar cell polarity
is_a: GO:0071963 ! establishment or maintenance of cell polarity regulating cell shape
created_by: dph
creation_date: 2010-08-23T09:46:01Z

[Term]
id: GO:0061247
name: mesonephric glomerular mesangium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the mesonephric glomerular mesangium over time, from its formation to the mature structure. The mesonephric glomerular mesangium is the thin membrane connective tissue composed of mesangial cells in the mesonephros, which helps to support the capillary loops in a renal glomerulus." [GOC:mtg_kidney_jan10]
is_a: GO:0072109 ! glomerular mesangium development
relationship: part_of GO:0061231 ! mesonephric glomerulus vasculature development
created_by: dph
creation_date: 2010-08-30T12:59:25Z

[Term]
id: GO:0061248
name: mesonephric glomerulus vasculature morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the mesonephric glomerulus vasculature are generated and organized. The mesonephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the mesonephric glomerulus." [GOC:mtg_kidney_jan10]
is_a: GO:0072103 ! glomerulus vasculature morphogenesis
relationship: part_of GO:0061231 ! mesonephric glomerulus vasculature development
relationship: part_of GO:0061234 ! mesonephric glomerulus morphogenesis
created_by: dph
creation_date: 2010-08-30T01:11:34Z

[Term]
id: GO:0061249
name: mesonephric glomerular capillary formation
namespace: biological_process
def: "The process that gives rise to a mesonephric glomerular capillary. This process pertains to the initial formation of a structure from unspecified parts." [GOC:mtg_kidney_jan10]
is_a: GO:0072104 ! glomerular capillary formation
relationship: part_of GO:0061248 ! mesonephric glomerulus vasculature morphogenesis
created_by: dph
creation_date: 2010-08-30T01:17:08Z

[Term]
id: GO:0061250
name: mesonephric glomerular epithelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a mesonephric glomerular epithelial cell. Mesonephric glomerular epithelial cells are specialized epithelial cells that form part of the mesonephric glomerulus; there are two types, mesonephric glomerular parietal epithelial cells and mesonephric glomerular visceral epithelial cells." [GOC:mtg_kidney_jan10]
is_a: GO:0061208 ! cell differentiation involved in mesonephros development
is_a: GO:0072311 ! glomerular epithelial cell differentiation
relationship: part_of GO:0061232 ! mesonephric glomerular epithelium development
created_by: dph
creation_date: 2010-08-30T01:20:03Z

[Term]
id: GO:0061251
name: mesonephric glomerular epithelial cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a mesonephric glomerular epithelial cell over time, from its formation to the mature structure. Mesonephric glomerular epithelial cells are specialized epithelial cells that form part of the mesonephric glomerulus; there are two types, mesonephric glomerular parietal epithelial cells and mesonephric glomerular visceral epithelial cells." [GOC:mtg_kidney_jan10]
is_a: GO:0072310 ! glomerular epithelial cell development
relationship: part_of GO:0061250 ! mesonephric glomerular epithelial cell differentiation
created_by: dph
creation_date: 2010-08-30T01:20:45Z

[Term]
id: GO:0061252
name: mesonephric glomerular epithelial cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric glomerular epithelial cell. Mesonephric glomerular epithelial cells are specialized epithelial cells that form part of the mesonephric glomerulus; there are two types, mesonephric glomerular parietal epithelial cells and mesonephric glomerular visceral epithelial cells." [GOC:mtg_kidney_jan10]
is_a: GO:0072314 ! glomerular epithelial cell fate commitment
relationship: part_of GO:0061250 ! mesonephric glomerular epithelial cell differentiation
created_by: dph
creation_date: 2010-08-30T01:23:50Z

[Term]
id: GO:0061253
name: mesonephric glomerular parietal epithelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a mesonephric glomerular parietal epithelial cell. Mesonephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport." [GOC:mtg_kidney_jan10]
is_a: GO:0061250 ! mesonephric glomerular epithelial cell differentiation
is_a: GO:0072139 ! glomerular parietal epithelial cell differentiation
created_by: dph
creation_date: 2010-08-30T01:26:47Z

[Term]
id: GO:0061254
name: mesonephric glomerular parietal epithelial cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a mesonephric glomerular parietal epithelial cell over time, from its formation to the mature structure. Mesonephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport." [GOC:mtg_kidney_jan10]
is_a: GO:0061251 ! mesonephric glomerular epithelial cell development
is_a: GO:0072016 ! glomerular parietal epithelial cell development
relationship: part_of GO:0061253 ! mesonephric glomerular parietal epithelial cell differentiation
created_by: dph
creation_date: 2010-08-30T01:30:36Z

[Term]
id: GO:0061255
name: mesonephric glomerular parietal epithelial cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric glomerular parietal epithelial cell. Mesonephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. These cells may also give rise to podocytes." [GOC:mtg_kidney_jan10]
is_a: GO:0061252 ! mesonephric glomerular epithelial cell fate commitment
is_a: GO:0072147 ! glomerular parietal epithelial cell fate commitment
relationship: part_of GO:0061253 ! mesonephric glomerular parietal epithelial cell differentiation
created_by: dph
creation_date: 2010-08-30T01:33:52Z

[Term]
id: GO:0061256
name: mesonephric glomerular visceral epithelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a mesonephric glomerular visceral epithelial cell. A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains \\\"feet\\\" that interdigitate with the \\\"feet\\\" of other glomerular epithelial cells in the mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0061250 ! mesonephric glomerular epithelial cell differentiation
is_a: GO:0072112 ! glomerular visceral epithelial cell differentiation
created_by: dph
creation_date: 2010-08-30T02:03:38Z

[Term]
id: GO:0061257
name: mesonephric glomerular visceral epithelial cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a mesonephric glomerular visceral epithelial cell over time, from its formation to the mature structure. A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains \\\"feet\\\" that interdigitate with the \\\"feet\\\" of other glomerular epithelial cells in the mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0061251 ! mesonephric glomerular epithelial cell development
is_a: GO:0072015 ! glomerular visceral epithelial cell development
relationship: part_of GO:0061256 ! mesonephric glomerular visceral epithelial cell differentiation
created_by: dph
creation_date: 2010-08-30T02:10:40Z

[Term]
id: GO:0061258
name: mesonephric glomerular visceral epithelial cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric glomerular visceral epithelial cell. A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains \\\"feet\\\" that interdigitate with the \\\"feet\\\" of other glomerular epithelial cells in the mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0061251 ! mesonephric glomerular epithelial cell development
is_a: GO:0072149 ! glomerular visceral epithelial cell fate commitment
relationship: part_of GO:0061256 ! mesonephric glomerular visceral epithelial cell differentiation
created_by: dph
creation_date: 2010-08-30T02:13:33Z

[Term]
id: GO:0061259
name: mesonephric glomerular mesangial cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the glomerular mesangial cells of the mesonephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
is_a: GO:0061260 ! mesonephric mesangial cell differentiation
is_a: GO:0072008 ! glomerular mesangial cell differentiation
relationship: part_of GO:0061247 ! mesonephric glomerular mesangium development
created_by: dph
creation_date: 2010-08-30T02:22:45Z

[Term]
id: GO:0061260
name: mesonephric mesangial cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesangial cells of the mesonephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
is_a: GO:0061208 ! cell differentiation involved in mesonephros development
is_a: GO:0072007 ! mesangial cell differentiation
created_by: dph
creation_date: 2010-08-30T02:25:08Z

[Term]
id: GO:0061261
name: mesenchymal to epithelial transition involved in mesonephros morphogenesis
namespace: biological_process
def: "A transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the mesonephros." [GOC:mtg_kidney_jan10]
synonym: "mesonephric mesenchyme to epithelial transition" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0060231 ! mesenchymal to epithelial transition
intersection_of: GO:0060231 ! mesenchymal to epithelial transition
intersection_of: part_of GO:0061206 ! mesonephros morphogenesis
relationship: part_of GO:0061206 ! mesonephros morphogenesis
created_by: dph
creation_date: 2010-08-30T02:35:15Z

[Term]
id: GO:0061262
name: mesonephric renal vesicle formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the mesonephros." [GOC:mtg_kidney_jan10]
synonym: "mesonephros formation" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072033 ! renal vesicle formation
relationship: part_of GO:0061243 ! mesonephric renal vesicle morphogenesis
created_by: dph
creation_date: 2010-08-30T02:41:20Z

[Term]
id: GO:0061263
name: mesonephric glomerular mesangial cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a glomerular mesangial cell in the mesonephros over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10]
is_a: GO:0072144 ! glomerular mesangial cell development
relationship: part_of GO:0061259 ! mesonephric glomerular mesangial cell differentiation
created_by: dph
creation_date: 2010-08-30T02:52:55Z

[Term]
id: GO:0061264
name: mesonephric glomerular mesangial cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric glomerular mesangial cell." [GOC:mtg_kidney_jan10]
is_a: GO:0072152 ! glomerular mesangial cell fate commitment
relationship: part_of GO:0061259 ! mesonephric glomerular mesangial cell differentiation
created_by: dph
creation_date: 2010-08-30T02:59:11Z

[Term]
id: GO:0061265
name: mesonephric nephron tubule epithelial cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the mesonephric nephron tubule as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
is_a: GO:0061208 ! cell differentiation involved in mesonephros development
is_a: GO:0072160 ! nephron tubule epithelial cell differentiation
relationship: part_of GO:0061242 ! mesonephric nephron tubule development
created_by: dph
creation_date: 2010-08-30T03:02:09Z

[Term]
id: GO:0061266
name: mesonephric interstitial fibroblast differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the interstitial fibroblasts of the mesonephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
synonym: "mesonephros interstitial cell differentiation" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0061208 ! cell differentiation involved in mesonephros development
is_a: GO:0072071 ! kidney interstitial fibroblast differentiation
created_by: dph
creation_date: 2010-08-30T03:12:17Z

[Term]
id: GO:0061267
name: mesonephric interstitial fibroblast development
namespace: biological_process
def: "The process whose specific outcome is the progression of a mesonephric interstitial fibroblast over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10]
synonym: "mesonephros interstitial cell development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072141 ! renal interstitial fibroblast development
relationship: part_of GO:0061266 ! mesonephric interstitial fibroblast differentiation
created_by: dph
creation_date: 2010-08-30T03:14:31Z

[Term]
id: GO:0061268
name: mesonephric interstitial fibroblast fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric interstitial fibroblast." [GOC:mtg_kidney_jan10]
is_a: GO:0072153 ! renal interstitial fibroblast fate commitment
relationship: part_of GO:0061266 ! mesonephric interstitial fibroblast differentiation
created_by: dph
creation_date: 2010-08-30T03:16:52Z

[Term]
id: GO:0061269
name: mesonephric glomerular mesangial cell proliferation involved in mesonephros development
namespace: biological_process
def: "The multiplication or reproduction of glomerular mesangial cells in the mesonephros, resulting in the expansion of the population." [GOC:mtg_kidney_jan10]
is_a: GO:0061209 ! cell proliferation involved in mesonephros development
is_a: GO:0072110 ! glomerular mesangial cell proliferation
relationship: part_of GO:0061247 ! mesonephric glomerular mesangium development
created_by: dph
creation_date: 2010-08-30T03:20:57Z

[Term]
id: GO:0061270
name: mesonephric intraglomerular mesangial cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of intraglomerular glomerular mesangium cells in the mesonephros by cell division, resulting in the expansion of their population. Intraglomerular mesangial cells are specialized pericytes located among the glomerular capillaries within a renal corpuscle of a kidney. They are required for filtration, structural support and phagocytosis." [GOC:mtg_kidney_jan10]
is_a: GO:0061269 ! mesonephric glomerular mesangial cell proliferation involved in mesonephros development
is_a: GO:0072123 ! intraglomerular mesangial cell proliferation
created_by: dph
creation_date: 2010-08-30T03:23:10Z

[Term]
id: GO:0061271
name: mesenchymal to epithelial transition involved in mesonephric renal vesicle formation
namespace: biological_process
def: "A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the mesonephric renal vesicle." [GOC:mtg_kidney_jan10]
is_a: GO:0061261 ! mesenchymal to epithelial transition involved in mesonephros morphogenesis
is_a: GO:0072036 ! mesenchymal to epithelial transition involved in renal vesicle formation
intersection_of: GO:0060231 ! mesenchymal to epithelial transition
intersection_of: part_of GO:0061262 ! mesonephric renal vesicle formation
relationship: part_of GO:0061262 ! mesonephric renal vesicle formation
created_by: dph
creation_date: 2010-08-30T03:26:30Z

[Term]
id: GO:0061272
name: mesonephric connecting tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the mesonephric connecting tubule over time, from its formation to the mature structure. The mesonephric connecting tubule is a tubular segment of the mesonephric nephron; it connects the distal tubule to the collecting duct in the mesonephros." [GOC:mtg_kidney_jan10]
synonym: "mesonephric collecting tubule development" EXACT [GOC:dph]
synonym: "mesonephric connecting duct development" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0061242 ! mesonephric nephron tubule development
is_a: GO:0072027 ! connecting tubule development
created_by: dph
creation_date: 2010-09-02T12:00:56Z

[Term]
id: GO:0061273
name: mesonephric distal tubule morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a mesonephric distal tubule are generated and organized. The mesonephric distal tubule is a mesonephric nephron tubule that begins at the macula densa and extends to the mesonephric connecting tubule." [GOC:mtg_kidney_jan10]
is_a: GO:0061240 ! mesonephric nephron tubule morphogenesis
is_a: GO:0072156 ! distal tubule morphogenesis
relationship: part_of GO:0061274 ! mesonephric distal tubule development
created_by: dph
creation_date: 2010-09-02T12:12:00Z

[Term]
id: GO:0061274
name: mesonephric distal tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the mesonephric distal tubule over time, from its formation to the mature structure. The mesonephric distal tubule is a mesonephric nephron tubule that begins at the terminal segment of the proximal tubule and ends at the mesonephric connecting tubule." [GOC:mtg_kidney_jan10]
is_a: GO:0061242 ! mesonephric nephron tubule development
is_a: GO:0072017 ! distal tubule development
created_by: dph
creation_date: 2010-09-02T12:16:25Z

[Term]
id: GO:0061275
name: mesonephric proximal tubule development
namespace: biological_process
def: "The progression of the mesonephric proximal tubule over time, from its formation to the mature structure. The mesonephric proximal tubule extends from the capsule to the distal tubule." [GOC:mtg_kidney_jan10]
is_a: GO:0061242 ! mesonephric nephron tubule development
is_a: GO:0072014 ! proximal tubule development
created_by: dph
creation_date: 2010-09-02T01:08:05Z

[Term]
id: GO:0061276
name: mesonephric proximal tubule morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a mesonephric proximal tubule are generated and organized. The mesonephric proximal tubule extends from the capsule to the distal tubule." [GOC:mtg_kidney_jan10]
is_a: GO:0061240 ! mesonephric nephron tubule morphogenesis
is_a: GO:0072158 ! proximal tubule morphogenesis
relationship: part_of GO:0061275 ! mesonephric proximal tubule development
created_by: dph
creation_date: 2010-09-02T01:11:02Z

[Term]
id: GO:0061277
name: mesonephric nephron tubule formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a mesonephric nephron tubule from unspecified parts. A mesonephric nephron tubule is an epithelial tube that is part of a nephron in the mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072172 ! mesonephric tubule formation
relationship: part_of GO:0061240 ! mesonephric nephron tubule morphogenesis
created_by: dph
creation_date: 2010-09-02T01:16:21Z

[Term]
id: GO:0061278
name: epithelial cell migration involved in mesonephric nephron tubule morphogenesis
namespace: biological_process
def: "The orderly movement of epithelial cells within a renal tubule that contributes to mesonephric nephron tubule morphogenesis." [GOC:mtg_kidney_jan10]
is_a: GO:0072155 ! epithelial cell migration involved in nephron tubule morphogenesis
intersection_of: GO:0010631 ! epithelial cell migration
intersection_of: part_of GO:0061240 ! mesonephric nephron tubule morphogenesis
relationship: part_of GO:0061240 ! mesonephric nephron tubule morphogenesis
created_by: dph
creation_date: 2010-09-02T01:18:53Z

[Term]
id: GO:0061279
name: epithelial cell migration involved in mesonephric distal tubule morphogenesis
namespace: biological_process
def: "The orderly movement of epithelial cells within a renal tubule that contributes to mesonephric distal tubule morphogenesis." [GOC:mtg_kidney_jan10]
is_a: GO:0061278 ! epithelial cell migration involved in mesonephric nephron tubule morphogenesis
is_a: GO:0072157 ! epithelial cell migration involved in distal tubule morphogenesis
intersection_of: GO:0010631 ! epithelial cell migration
intersection_of: part_of GO:0061273 ! mesonephric distal tubule morphogenesis
relationship: part_of GO:0061273 ! mesonephric distal tubule morphogenesis
created_by: dph
creation_date: 2010-09-02T01:20:56Z

[Term]
id: GO:0061280
name: epithelial cell migration involved in mesonephric proximal tubule morphogenesis
namespace: biological_process
def: "The orderly movement of epithelial cells within a renal tubule that contributes to mesonephric proximal tubule morphogenesis." [GOC:mtg_kidney_jan10]
is_a: GO:0061278 ! epithelial cell migration involved in mesonephric nephron tubule morphogenesis
is_a: GO:0072159 ! epithelial cell migration involved in proximal tubule morphogenesis
intersection_of: GO:0010631 ! epithelial cell migration
intersection_of: part_of GO:0061276 ! mesonephric proximal tubule morphogenesis
relationship: part_of GO:0061276 ! mesonephric proximal tubule morphogenesis
created_by: dph
creation_date: 2010-09-02T01:23:43Z

[Term]
id: GO:0061281
name: specification of mesonephric connecting tubule identity
namespace: biological_process
def: "The process in which the connecting tubule of the mesonephric nephron acquires its identity." [GOC:mtg_kidney_jan10]
synonym: "specification of mesonephric collecting tubule identity" EXACT [GOC:dph]
is_a: GO:0061282 ! specification of mesonephric nephron tubule identity
is_a: GO:0072085 ! specification of connecting tubule identity
relationship: part_of GO:0061272 ! mesonephric connecting tubule development
created_by: dph
creation_date: 2010-09-02T01:26:09Z

[Term]
id: GO:0061282
name: specification of mesonephric nephron tubule identity
namespace: biological_process
def: "The process in which the tubules arranged along the proximal/distal axis of the mesonephric nephron acquire their identity." [GOC:mtg_kidney_jan10]
is_a: GO:0061227 ! pattern specification involved in mesonephros development
is_a: GO:0072081 ! specification of nephron tubule identity
relationship: part_of GO:0061226 ! proximal/distal pattern formation involved in mesonephric nephron development
relationship: part_of GO:0061277 ! mesonephric nephron tubule formation
created_by: dph
creation_date: 2010-09-02T01:37:44Z

[Term]
id: GO:0061283
name: specification of mesonephric distal tubule identity
namespace: biological_process
def: "The process in which the distal tubule of the mesonephric nephron acquires its identity." [GOC:mtg_kidney_jan10]
is_a: GO:0061282 ! specification of mesonephric nephron tubule identity
is_a: GO:0072084 ! specification of distal tubule identity
relationship: part_of GO:0061273 ! mesonephric distal tubule morphogenesis
created_by: dph
creation_date: 2010-09-02T01:42:10Z

[Term]
id: GO:0061284
name: specification of mesonephric proximal tubule identity
namespace: biological_process
def: "The process in which the proximal tubule of the mesonephric nephron acquires its identity." [GOC:mtg_kidney_jan10]
is_a: GO:0061282 ! specification of mesonephric nephron tubule identity
is_a: GO:0072082 ! specification of proximal tubule identity
relationship: part_of GO:0061276 ! mesonephric proximal tubule morphogenesis
created_by: dph
creation_date: 2010-09-02T01:44:24Z

[Term]
id: GO:0061285
name: mesonephric capsule development
namespace: biological_process
def: "The progression of the mesonephric capsule over time, from its formation to the mature structure. The mesonephric capsule is the tough fibrous layer surrounding the mesonephros, covered in a thick layer of perinephric adipose tissue." [GOC:mtg_kidney_jan10]
is_a: GO:0072127 ! renal capsule development
relationship: part_of GO:0001823 ! mesonephros development
created_by: dph
creation_date: 2010-09-02T01:50:06Z

[Term]
id: GO:0061286
name: mesonephric capsule morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the mesonephric capsule are generated and organized. The mesonephric capsule is the tough fibrous layer surrounding the mesonephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage." [GOC:mtg_kidney_jan10]
is_a: GO:0072128 ! renal capsule morphogenesis
relationship: part_of GO:0061285 ! mesonephric capsule development
created_by: dph
creation_date: 2010-09-02T01:53:31Z

[Term]
id: GO:0061287
name: mesonephric capsule formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a mesonephric capsule from unspecified parts. The mesonephric capsule is the tough fibrous layer surrounding the mesonephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage." [GOC:mtg_kidney_jan10]
is_a: GO:0072129 ! renal capsule formation
relationship: part_of GO:0061286 ! mesonephric capsule morphogenesis
created_by: dph
creation_date: 2010-09-02T01:55:03Z

[Term]
id: GO:0061288
name: mesonephric capsule specification
namespace: biological_process
def: "The regionalization process in which the identity of the mesonephric capsule is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:mtg_kidney_jan10]
is_a: GO:0061227 ! pattern specification involved in mesonephros development
is_a: GO:0072130 ! renal capsule specification
relationship: part_of GO:0061287 ! mesonephric capsule formation
created_by: dph
creation_date: 2010-09-02T01:56:20Z

[Term]
id: GO:0061289
name: Wnt signaling pathway involved in kidney development
namespace: biological_process
def: "The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the kidney over time." [GOC:mtg_kidney_jan10]
synonym: "Wnt receptor signaling pathway involved in kidney development" EXACT []
synonym: "Wnt receptor signalling pathway involved in kidney development" EXACT [GOC:mah]
synonym: "Wnt-activated signaling pathway involved in kidney development" EXACT [GOC:signaling]
is_a: GO:0016055 ! Wnt signaling pathway
is_a: GO:0060995 ! cell-cell signaling involved in kidney development
intersection_of: GO:0016055 ! Wnt signaling pathway
intersection_of: part_of GO:0001822 ! kidney development
relationship: part_of GO:0001822 ! kidney development
created_by: dph
creation_date: 2010-09-03T12:04:50Z

[Term]
id: GO:0061290
name: canonical Wnt signaling pathway involved in metanephric kidney development
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contribute to the progression of the metanephric kidney over time. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [GOC:mtg_kidney_jan10]
synonym: "canonical Wnt receptor signaling pathway involved in metanephric kidney development" EXACT []
synonym: "canonical Wnt receptor signalling pathway involved in metanephric kidney development" EXACT [GOC:mah]
synonym: "canonical Wnt-activated signaling pathway involved in metanephric kidney development" EXACT [GOC:signaling]
is_a: GO:0060070 ! canonical Wnt signaling pathway
is_a: GO:0061289 ! Wnt signaling pathway involved in kidney development
is_a: GO:0072204 ! cell-cell signaling involved in metanephros development
intersection_of: GO:0060070 ! canonical Wnt signaling pathway
intersection_of: part_of GO:0001656 ! metanephros development
relationship: part_of GO:0001656 ! metanephros development
created_by: dph
creation_date: 2010-09-03T12:06:10Z

[Term]
id: GO:0061291
name: canonical Wnt signaling pathway involved in ureteric bud branching
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to the branching of the ureteric bud. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [GOC:mtg_kidney_jan10]
synonym: "canonical Wnt receptor signaling pathway involved in ureteric bud branching" EXACT [GOC:signaling]
synonym: "canonical Wnt receptor signalling pathway involved in ureteric bud branching" EXACT [GOC:mah]
is_a: GO:0061290 ! canonical Wnt signaling pathway involved in metanephric kidney development
is_a: GO:0061292 ! canonical Wnt signaling pathway involved in mesonephros development
intersection_of: GO:0060070 ! canonical Wnt signaling pathway
intersection_of: part_of GO:0001658 ! branching involved in ureteric bud morphogenesis
relationship: part_of GO:0001658 ! branching involved in ureteric bud morphogenesis
created_by: dph
creation_date: 2010-09-03T12:15:19Z

[Term]
id: GO:0061292
name: canonical Wnt signaling pathway involved in mesonephros development
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to the progression of the mesonephros over time. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [GOC:mtg_kidney_jan10]
synonym: "canonical Wnt receptor signaling pathway involved in mesonephros development" EXACT []
synonym: "canonical Wnt receptor signalling pathway involved in mesonephros development" EXACT [GOC:mah]
synonym: "canonical Wnt-activated signaling pathway involved in mesonephros development" EXACT [GOC:signaling]
is_a: GO:0060070 ! canonical Wnt signaling pathway
is_a: GO:0061210 ! cell-cell signaling involved in mesonephros development
is_a: GO:0061289 ! Wnt signaling pathway involved in kidney development
intersection_of: GO:0060070 ! canonical Wnt signaling pathway
intersection_of: part_of GO:0001823 ! mesonephros development
relationship: part_of GO:0001823 ! mesonephros development
created_by: dph
creation_date: 2010-09-03T12:23:09Z

[Term]
id: GO:0061293
name: canonical Wnt signaling pathway involved in mesonephric nephron development
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contribute to the progression of the mesonephric nephron over time. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [GOC:mtg_kidney_jan10]
synonym: "canonical Wnt receptor signaling pathway involved in mesonephric nephron development" EXACT []
synonym: "canonical Wnt receptor signalling pathway involved in mesonephric nephron development" EXACT [GOC:mah]
synonym: "canonical Wnt-activated signaling pathway involved in mesonephric nephron development" EXACT [GOC:signaling]
is_a: GO:0061292 ! canonical Wnt signaling pathway involved in mesonephros development
intersection_of: GO:0060070 ! canonical Wnt signaling pathway
intersection_of: part_of GO:0061215 ! mesonephric nephron development
relationship: part_of GO:0061215 ! mesonephric nephron development
created_by: dph
creation_date: 2010-09-03T12:49:43Z

[Term]
id: GO:0061294
name: mesonephric renal vesicle induction
namespace: biological_process
def: "Signaling at short range between cells of the ureteric bud terminus and the kidney mesenchyme that positively regulates the formation of the mesonephric renal vesicle." [GOC:mtg_kidney_jan10]
is_a: GO:0061213 ! positive regulation of mesonephros development
is_a: GO:0072034 ! renal vesicle induction
relationship: positively_regulates GO:0061262 ! mesonephric renal vesicle formation
created_by: dph
creation_date: 2010-09-03T12:57:59Z

[Term]
id: GO:0061295
name: regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis
namespace: biological_process
def: "Any process that modulates the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the mesonephros." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10]
synonym: "regulation of mesenchymal stem cell apoptosis involved in mesonephric nephron morphogenesis" NARROW []
synonym: "regulation of mesenchymal stem cell apoptotic process involved in mesonephric nephron morphogenesis" EXACT []
is_a: GO:0061217 ! regulation of mesonephros development
is_a: GO:0072039 ! regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1901146 ! mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis
relationship: regulates GO:0061235 ! mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis
relationship: regulates GO:1901146 ! mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis
created_by: dph
creation_date: 2010-09-06T09:48:56Z

[Term]
id: GO:0061296
name: negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis
namespace: biological_process
def: "Any process that reduces the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the mesonephros." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10]
synonym: "negative regulation of mesenchymal stem cell apoptosis involved in mesonephric nephron morphogenesis" NARROW []
synonym: "negative regulation of mesenchymal stem cell apoptotic process involved in mesonephric nephron morphogenesis" EXACT []
is_a: GO:0061218 ! negative regulation of mesonephros development
is_a: GO:0061295 ! regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis
is_a: GO:0072040 ! negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1901146 ! mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis
relationship: negatively_regulates GO:0061235 ! mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis
relationship: negatively_regulates GO:1901146 ! mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis
created_by: dph
creation_date: 2010-09-06T09:54:49Z

[Term]
id: GO:0061297
name: positive regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis
namespace: biological_process
def: "Any process that increases the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the mesonephros." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10]
synonym: "positive regulation of mesenchymal stem cell apoptosis involved in mesonephric nephron morphogenesis" NARROW []
synonym: "positive regulation of mesenchymal stem cell apoptotic process involved in mesonephric nephron morphogenesis" EXACT []
is_a: GO:0061213 ! positive regulation of mesonephros development
is_a: GO:0061295 ! regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis
is_a: GO:0072041 ! positive regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1901146 ! mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis
relationship: positively_regulates GO:0061235 ! mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis
relationship: positively_regulates GO:1901146 ! mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis
created_by: dph
creation_date: 2010-09-06T09:58:59Z

[Term]
id: GO:0061298
name: retina vasculature development in camera-type eye
namespace: biological_process
def: "The process whose specific outcome is the progression of the vasculature of the retina over time, from its formation to the mature structure." [GOC:BHF, GOC:dph]
synonym: "retinal vasculature development" EXACT [GOC:dph]
is_a: GO:0001944 ! vasculature development
relationship: part_of GO:0060041 ! retina development in camera-type eye
created_by: dph
creation_date: 2010-09-06T03:27:06Z

[Term]
id: GO:0061299
name: retina vasculature morphogenesis in camera-type eye
namespace: biological_process
def: "The process in which the vasculature of the retina is generated and organized." [GOC:BHF, GOC:dph]
synonym: "retinal vasculature morphogenesis" EXACT [GOC:dph]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0061298 ! retina vasculature development in camera-type eye
created_by: dph
creation_date: 2010-09-06T03:28:25Z

[Term]
id: GO:0061300
name: cerebellum vasculature development
namespace: biological_process
def: "The process whose specific outcome is the progression of the vasculature of the cerebellum over time, from its formation to the mature structure." [GOC:dph]
is_a: GO:0001944 ! vasculature development
created_by: dph
creation_date: 2010-09-06T03:36:40Z

[Term]
id: GO:0061301
name: cerebellum vasculature morphogenesis
namespace: biological_process
def: "The process in which the vasculature of the cerebellum is generated and organized." [GOC:BHF, GOC:dph]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0021549 ! cerebellum development
relationship: part_of GO:0061300 ! cerebellum vasculature development
created_by: dph
creation_date: 2010-09-06T03:38:05Z

[Term]
id: GO:0061302
name: smooth muscle cell-matrix adhesion
namespace: biological_process
def: "The binding of a smooth muscle cell to the extracellular matrix via adhesion molecules." [GOC:BHF, GOC:dph, PMID:8837777]
is_a: GO:0007160 ! cell-matrix adhesion
created_by: dph
creation_date: 2010-09-14T11:08:00Z

[Term]
id: GO:0061303
name: cornea development in camera-type eye
namespace: biological_process
def: "The progression of the cornea over time, from its formation to the mature structure. The cornea is the transparent structure that covers the anterior of the eye." [GOC:dph]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0043010 ! camera-type eye development
created_by: dph
creation_date: 2010-09-14T02:09:08Z

[Term]
id: GO:0061304
name: retinal blood vessel morphogenesis
namespace: biological_process
def: "The process whose specific outcome is the progression of a blood vessel of the retina over time, from its formation to the mature structure." [GOC:BHF, GOC:dph]
is_a: GO:0048514 ! blood vessel morphogenesis
is_a: GO:0061299 ! retina vasculature morphogenesis in camera-type eye
created_by: dph
creation_date: 2010-09-16T09:02:59Z

[Term]
id: GO:0061305
name: maintenance of bipolar cell polarity regulating cell shape
namespace: biological_process
def: "The maintenance of established bipolar anisotropic intracellular organization or cell growth patterns that results in the shaping of a cell." [GOC:dph, GOC:vw]
is_a: GO:0061246 ! establishment or maintenance of bipolar cell polarity regulating cell shape
created_by: dph
creation_date: 2010-09-16T09:25:18Z

[Term]
id: GO:0061306
name: DNA strand renaturation involved in double-strand break repair
namespace: biological_process
def: "The identification and annealing of complementary base pairs in single-strand DNA that contributes to double-strand break repair." [GOC:dph]
is_a: GO:0000733 ! DNA strand renaturation
intersection_of: GO:0000733 ! DNA strand renaturation
intersection_of: part_of GO:0006302 ! double-strand break repair
relationship: part_of GO:0006302 ! double-strand break repair
relationship: part_of GO:0045002 ! double-strand break repair via single-strand annealing
created_by: dph
creation_date: 2010-09-21T09:36:47Z

[Term]
id: GO:0061307
name: cardiac neural crest cell differentiation involved in heart development
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a cardiac neural crest cell that will migrate to the heart and contribute to its development. Cardiac neural crest cells are specialized cells that migrate toward the heart from the third, fourth and sixth pharyngeal arches." [GOC:dph, GOC:mtg_heart, PMID:19705442]
is_a: GO:0014033 ! neural crest cell differentiation
is_a: GO:0035051 ! cardiocyte differentiation
intersection_of: GO:0014033 ! neural crest cell differentiation
intersection_of: part_of GO:0007507 ! heart development
relationship: part_of GO:0007507 ! heart development
created_by: dph
creation_date: 2010-09-23T08:50:56Z

[Term]
id: GO:0061308
name: cardiac neural crest cell development involved in heart development
namespace: biological_process
def: "The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the development of the heart." [GOC:dph, GOC:mtg_heart]
is_a: GO:0014032 ! neural crest cell development
intersection_of: GO:0014032 ! neural crest cell development
intersection_of: part_of GO:0007507 ! heart development
relationship: part_of GO:0007507 ! heart development
relationship: part_of GO:0061307 ! cardiac neural crest cell differentiation involved in heart development
created_by: dph
creation_date: 2010-09-23T09:01:49Z

[Term]
id: GO:0061309
name: cardiac neural crest cell development involved in outflow tract morphogenesis
namespace: biological_process
def: "The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the shaping of the outflow tract." [GOC:dph, GOC:mtg_heart]
is_a: GO:0061308 ! cardiac neural crest cell development involved in heart development
intersection_of: GO:0014032 ! neural crest cell development
intersection_of: part_of GO:0003151 ! outflow tract morphogenesis
relationship: part_of GO:0003151 ! outflow tract morphogenesis
created_by: dph
creation_date: 2010-09-23T09:08:37Z

[Term]
id: GO:0061310
name: canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in cardiac neural crest cell differentiation." [GOC:dph, GOC:mtg_heart]
synonym: "canonical Wnt receptor signaling pathway involved in cardiac neural crest cell differentiation involved in heart development" EXACT [GOC:signaling]
synonym: "canonical Wnt receptor signalling pathway involved in cardiac neural crest cell differentiation involved in heart development" EXACT [GOC:mah]
synonym: "canonical Wnt-activated signaling pathway involved in cardiac neural crest cell differentiation involved in heart development" EXACT [GOC:signaling]
is_a: GO:0044335 ! canonical Wnt signaling pathway involved in neural crest cell differentiation
is_a: GO:0061316 ! canonical Wnt signaling pathway involved in heart development
intersection_of: GO:0060070 ! canonical Wnt signaling pathway
intersection_of: part_of GO:0061307 ! cardiac neural crest cell differentiation involved in heart development
relationship: part_of GO:0061307 ! cardiac neural crest cell differentiation involved in heart development
created_by: dph
creation_date: 2010-09-23T09:12:36Z

[Term]
id: GO:0061311
name: cell surface receptor signaling pathway involved in heart development
namespace: biological_process
def: "Any series of molecular signals initiated by the binding of a receptor on the surface of a cell to a physiological ligand, which contributes to the progression of the heart over time." [GOC:dph, GOC:mtg_heart, GOC:signaling]
synonym: "cell surface receptor linked signaling pathway involved in heart development" EXACT [GOC:bf]
synonym: "cell surface receptor linked signalling pathway involved in heart development" EXACT [GOC:mah]
is_a: GO:0007166 ! cell surface receptor signaling pathway
intersection_of: GO:0007166 ! cell surface receptor signaling pathway
intersection_of: part_of GO:0007507 ! heart development
relationship: part_of GO:0007507 ! heart development
created_by: dph
creation_date: 2010-09-23T09:18:32Z

[Term]
id: GO:0061312
name: BMP signaling pathway involved in heart development
namespace: biological_process
def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the progression of the heart over time." [GOC:dph, GOC:mtg_heart]
synonym: "BMP signalling pathway involved in heart development" EXACT [GOC:mah]
is_a: GO:0030509 ! BMP signaling pathway
is_a: GO:0061311 ! cell surface receptor signaling pathway involved in heart development
is_a: GO:1901213 ! regulation of transcription from RNA polymerase II promoter involved in heart development
intersection_of: GO:0030509 ! BMP signaling pathway
intersection_of: part_of GO:0007507 ! heart development
relationship: part_of GO:0007507 ! heart development
created_by: dph
creation_date: 2010-09-23T11:02:14Z

[Term]
id: GO:0061313
name: fibroblast growth factor receptor signaling pathway involved in heart development
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands and contributing to the progression of the heart over time." [GOC:mtg_heart]
synonym: "fibroblast growth factor receptor signalling pathway involved in heart development" EXACT [GOC:mah]
is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway
is_a: GO:0061311 ! cell surface receptor signaling pathway involved in heart development
intersection_of: GO:0008543 ! fibroblast growth factor receptor signaling pathway
intersection_of: part_of GO:0007507 ! heart development
relationship: part_of GO:0007507 ! heart development
created_by: dph
creation_date: 2010-09-24T08:15:08Z

[Term]
id: GO:0061314
name: Notch signaling involved in heart development
namespace: biological_process
def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell and contributing to the progression of the heart over time." [GOC:mtg_heart]
synonym: "Notch signalling involved in heart development" EXACT [GOC:mah]
is_a: GO:0007219 ! Notch signaling pathway
is_a: GO:0061311 ! cell surface receptor signaling pathway involved in heart development
intersection_of: GO:0007219 ! Notch signaling pathway
intersection_of: part_of GO:0007507 ! heart development
relationship: part_of GO:0007507 ! heart development
created_by: dph
creation_date: 2010-09-24T08:25:22Z

[Term]
id: GO:0061315
name: canonical Wnt signaling pathway involved in positive regulation of cardiac muscle cell proliferation
namespace: biological_process
def: "The canonical Wnt signaling pathway that contributes to an expansion of the population of cardiac muscle cells." [GOC:mtg_heart]
synonym: "canonical Wnt receptor signaling pathway involved in positive regulation of cardiac muscle cell proliferation" EXACT []
synonym: "canonical Wnt receptor signalling pathway involved in positive regulation of cardiac muscle cell proliferation" EXACT [GOC:mah]
synonym: "canonical Wnt-activated signaling pathway involved in positive regulation of cardiac muscle cell proliferation" EXACT [GOC:signaling]
is_a: GO:0044340 ! canonical Wnt signaling pathway involved in regulation of cell proliferation
is_a: GO:0061316 ! canonical Wnt signaling pathway involved in heart development
intersection_of: GO:0061316 ! canonical Wnt signaling pathway involved in heart development
intersection_of: part_of GO:0060045 ! positive regulation of cardiac muscle cell proliferation
relationship: part_of GO:0060045 ! positive regulation of cardiac muscle cell proliferation
created_by: dph
creation_date: 2010-09-24T08:53:58Z

[Term]
id: GO:0061316
name: canonical Wnt signaling pathway involved in heart development
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to the progression of the heart over time. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [GOC:mtg_heart]
synonym: "canonical Wnt receptor signaling pathway involved in heart development" EXACT [GOC:signaling]
synonym: "canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:mah]
synonym: "canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:signaling]
is_a: GO:0003306 ! Wnt signaling pathway involved in heart development
is_a: GO:0060070 ! canonical Wnt signaling pathway
intersection_of: GO:0060070 ! canonical Wnt signaling pathway
intersection_of: part_of GO:0007507 ! heart development
relationship: part_of GO:0007507 ! heart development
created_by: dph
creation_date: 2010-09-24T09:25:03Z

[Term]
id: GO:0061317
name: canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin and contributing to cardiac muscle cell fate commitment. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [GOC:mtg_heart, PMID:17576928]
synonym: "canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:signaling]
synonym: "canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:mah]
synonym: "canonical Wnt-activated signaling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:signaling]
is_a: GO:0061316 ! canonical Wnt signaling pathway involved in heart development
intersection_of: GO:0060070 ! canonical Wnt signaling pathway
intersection_of: part_of GO:0060923 ! cardiac muscle cell fate commitment
relationship: part_of GO:0060923 ! cardiac muscle cell fate commitment
created_by: dph
creation_date: 2010-09-24T09:29:21Z

[Term]
id: GO:0061318
name: renal filtration cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a renal filtration cell. Renal filtration cells are specialized cells of the renal system that filter fluids by charge, size or both. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [GOC:dph, GOC:mtg_kidney_jan10]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0072001 ! renal system development
created_by: dph
creation_date: 2010-09-24T12:18:35Z

[Term]
id: GO:0061319
name: nephrocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a nephrocyte. A nephrocyte is an insect renal cell that filters hemolymph. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [CL:0002520, GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135]
is_a: GO:0061318 ! renal filtration cell differentiation
created_by: dph
creation_date: 2010-09-24T12:23:29Z

[Term]
id: GO:0061320
name: pericardial nephrocyte differentiation
namespace: biological_process
alt_id: GO:0007513
def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a pericardial nephrocyte. A pericardial nephrocyte is an insect renal cell that filters hemolymph and is found with other pericardial nephrocytes in two rows flanking the dorsal vessel. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [CL:0000474, GOC:dph, GOC:mtg_kidney_jan10, GOC:sart, PMID:19783135]
synonym: "pericardial cell differentiation" NARROW []
is_a: GO:0061319 ! nephrocyte differentiation
created_by: dph
creation_date: 2010-09-24T12:25:53Z

[Term]
id: GO:0061321
name: garland nephrocyte differentiation
namespace: biological_process
alt_id: GO:0007514
def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a garland nephrocyte. A garland nephrocyte is an insect renal cell that filters hemolymph and forms a ring with other garland nephrocytes around the esophagus. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [CL:0000486, GOC:dph, GOC:mtg_kidney_jan10, GOC:sart, PMID:19783135]
synonym: "garland cell differentiation" EXACT []
is_a: GO:0061319 ! nephrocyte differentiation
relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm
created_by: dph
creation_date: 2010-09-24T12:28:16Z

[Term]
id: GO:0061322
name: disseminated nephrocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a disseminated nephrocyte. A disseminated nephrocyte is an insect renal cell that filters hemolymph and is found at scattered locations in the fat body or other tissues. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [CL:0002524, GOC:19783135, GOC:dph, GOC:mtg_kidney_jan10]
is_a: GO:0061319 ! nephrocyte differentiation
created_by: dph
creation_date: 2010-09-24T12:30:46Z

[Term]
id: GO:0061323
name: cell proliferation involved in heart morphogenesis
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the heart." [GOC:dph, GOC:mtg_heart]
is_a: GO:0008283 ! cell proliferation
intersection_of: GO:0008283 ! cell proliferation
intersection_of: part_of GO:0003007 ! heart morphogenesis
relationship: part_of GO:0003007 ! heart morphogenesis
created_by: dph
creation_date: 2010-09-28T09:05:26Z

[Term]
id: GO:0061324
name: canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation
namespace: biological_process
def: "The canonical Wnt signaling pathway that contributes to the modulation of the expansion of a population of cardiac outflow tract cells." [GOC:dph, GOC:mtg_heart]
synonym: "canonical Wnt receptor signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation" EXACT []
synonym: "canonical Wnt receptor signalling pathway involved in positive regulation of cardiac outflow tract cell proliferation" EXACT [GOC:mah]
synonym: "canonical Wnt-activated signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation" EXACT [GOC:signaling]
is_a: GO:0044340 ! canonical Wnt signaling pathway involved in regulation of cell proliferation
is_a: GO:0061316 ! canonical Wnt signaling pathway involved in heart development
is_a: GO:1901963 ! regulation of cell proliferation involved in outflow tract morphogenesis
relationship: regulates GO:0061325 ! cell proliferation involved in outflow tract morphogenesis
created_by: dph
creation_date: 2010-09-28T09:19:37Z

[Term]
id: GO:0061325
name: cell proliferation involved in outflow tract morphogenesis
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the outflow tract." [GOC:dph, GOC:mtg_heart]
is_a: GO:0061323 ! cell proliferation involved in heart morphogenesis
intersection_of: GO:0008283 ! cell proliferation
intersection_of: part_of GO:0003151 ! outflow tract morphogenesis
relationship: part_of GO:0003151 ! outflow tract morphogenesis
created_by: dph
creation_date: 2010-09-28T09:29:30Z

[Term]
id: GO:0061326
name: renal tubule development
namespace: biological_process
def: "The progression of the renal tubule over time from its formation to the mature form. A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis." [GOC:dph, GOC:mtg_kidney_jan10]
is_a: GO:0035295 ! tube development
is_a: GO:0060429 ! epithelium development
relationship: part_of GO:0072001 ! renal system development
created_by: dph
creation_date: 2010-09-28T12:50:43Z

[Term]
id: GO:0061327
name: anterior Malpighian tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the anterior Malpighian tubule over time, from its formation to the mature structure. The pair of anterior tubules arise from a dorsal region of the embryonic hindgut and projects forwards through the body cavity. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which connects with the posterior part of the gut." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135]
is_a: GO:0072002 ! Malpighian tubule development
created_by: dph
creation_date: 2010-09-28T01:23:18Z

[Term]
id: GO:0061328
name: posterior Malpighian tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the posterior Malpighian tubule over time, from its formation to the mature structure. The pair of posterior tubules arise from a ventrolateral region of the embryonic hindgut and project backwards through the body cavity. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which connects with the posterior part of the gut." [GOC:dph, GOC:mtg_kidney_jan10]
is_a: GO:0072002 ! Malpighian tubule development
created_by: dph
creation_date: 2010-09-28T01:24:35Z

[Term]
id: GO:0061329
name: Malpighian tubule principal cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a Malpighian tubule principal cell. A Malpighian tubule principal cell is an epithelial secretory cell that transports cations into the lumen of the tubule." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135]
is_a: GO:0030855 ! epithelial cell differentiation
relationship: part_of GO:0072002 ! Malpighian tubule development
created_by: dph
creation_date: 2010-09-28T01:26:33Z

[Term]
id: GO:0061330
name: Malpighian tubule stellate cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a Malpighian tubule stellate cell. A Malpighian tubule stellate cell is a specialized epithelial secretory cell that moves chloride ions and water across the tubule epithelium." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135]
is_a: GO:0030855 ! epithelial cell differentiation
relationship: part_of GO:0072002 ! Malpighian tubule development
created_by: dph
creation_date: 2010-09-28T01:32:55Z

[Term]
id: GO:0061331
name: epithelial cell proliferation involved in Malpighian tubule morphogenesis
namespace: biological_process
def: "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population and contributing to the shaping of a Malpighian tubule." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135]
is_a: GO:2001013 ! epithelial cell proliferation involved in renal tubule morphogenesis
intersection_of: GO:0050673 ! epithelial cell proliferation
intersection_of: part_of GO:0007443 ! Malpighian tubule morphogenesis
relationship: part_of GO:0007443 ! Malpighian tubule morphogenesis
created_by: dph
creation_date: 2010-09-28T02:01:02Z

[Term]
id: GO:0061332
name: Malpighian tubule bud morphogenesis
namespace: biological_process
def: "The morphogenetic process in which a bud forms from the embryonic hindgut tube to form the Malpighian tubule. A bud is a protrusion that forms from the tube by localized changes in cell shape and position." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135]
synonym: "Malpighian tubule formation" EXACT [GOC:dph]
is_a: GO:0060572 ! morphogenesis of an epithelial bud
is_a: GO:0072175 ! epithelial tube formation
relationship: part_of GO:0007443 ! Malpighian tubule morphogenesis
created_by: dph
creation_date: 2010-09-28T01:39:32Z

[Term]
id: GO:0061333
name: renal tubule morphogenesis
namespace: biological_process
def: "The process in which the renal tubule is generated by specification of cell fate, through the maintenance of cell polarity, regulated cell proliferation and morphogenetic cell rearrangements, shape changes and growth. A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis." [GOC:dph, GOC:mtg_kidney_jan10]
is_a: GO:0060562 ! epithelial tube morphogenesis
relationship: part_of GO:0061326 ! renal tubule development
created_by: dph
creation_date: 2010-09-28T01:43:04Z

[Term]
id: GO:0061334
name: cell rearrangement involved in Malpighian tubule morphogenesis
namespace: biological_process
def: "The movement of an epithelial cell with respect to other epithelial cells that contributes to the shaping of the Malpighian tubule." [GOC:dph, GOC:mtg_kidney_jan10]
synonym: "cell migration involved in Malpighian tubule morphogenesis" EXACT []
is_a: GO:0016477 ! cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: part_of GO:0007443 ! Malpighian tubule morphogenesis
relationship: part_of GO:0007443 ! Malpighian tubule morphogenesis
created_by: dph
creation_date: 2010-09-28T02:04:05Z

[Term]
id: GO:0061335
name: cell growth involved in Malpighian tubule morphogenesis
namespace: biological_process
def: "The growth of an epithelial cell dependent on cycles of endoreplication, where growth contributes to the shaping of the Malpighian tubule." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135]
is_a: GO:0048588 ! developmental cell growth
is_a: GO:0060560 ! developmental growth involved in morphogenesis
intersection_of: GO:0048588 ! developmental cell growth
intersection_of: part_of GO:0007443 ! Malpighian tubule morphogenesis
relationship: part_of GO:0007443 ! Malpighian tubule morphogenesis
created_by: dph
creation_date: 2010-09-28T02:08:25Z

[Term]
id: GO:0061336
name: cell morphogenesis involved in Malpighian tubule morphogenesis
namespace: biological_process
def: "The shape change of an epithelial cell from a columnar to squamous cell morphology that contributes to the shaping of the Malpighian tubule." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135]
is_a: GO:0000904 ! cell morphogenesis involved in differentiation
intersection_of: GO:0000904 ! cell morphogenesis involved in differentiation
intersection_of: part_of GO:0007443 ! Malpighian tubule morphogenesis
relationship: part_of GO:0007443 ! Malpighian tubule morphogenesis
created_by: dph
creation_date: 2010-09-28T02:11:47Z

[Term]
id: GO:0061337
name: cardiac conduction
namespace: biological_process
def: "Transfer of an organized electrical impulse across the heart to coordinate the contraction of cardiac muscles. The process begins with generation of an action potential (in the sinoatrial node (SA) in humans) and ends with a change in the rate, frequency, or extent of the contraction of the heart muscles." [GOC:dph]
is_a: GO:0008016 ! regulation of heart contraction
is_a: GO:0035637 ! multicellular organismal signaling
created_by: dph
creation_date: 2010-09-29T08:46:05Z

[Term]
id: GO:0061338
name: obsolete atrioventricular node impulse conduction delay
namespace: biological_process
def: "Obsolete. A heart process that modulates the propagation of the signal that causes the heart muscle to contract." [GOC:dph]
comment: This term was made obsolete because it was created before the cardiac conduction overhaul, and represents a measurement rather than a process.
synonym: "atrioventricular node impulse conduction delay" EXACT []
is_obsolete: true
consider: GO:0086016
created_by: dph
creation_date: 2010-09-29T08:55:53Z

[Term]
id: GO:0061339
name: establishment or maintenance of monopolar cell polarity
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of monopolar intracellular organization or cell growth patterns. Monopolar cell organization is directional organization along an axis." [GOC:dph, GOC:vw]
is_a: GO:0007163 ! establishment or maintenance of cell polarity
created_by: dph
creation_date: 2010-09-29T09:10:05Z

[Term]
id: GO:0061340
name: establishment or maintenance of monopolar cell polarity regulating cell shape
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of a monopolar intracellular organization or cell growth patterns that regulate the shape of a cell." [GOC:dph, GOC:vw]
is_a: GO:0061339 ! establishment or maintenance of monopolar cell polarity
is_a: GO:0071963 ! establishment or maintenance of cell polarity regulating cell shape
created_by: dph
creation_date: 2010-09-29T09:13:55Z

[Term]
id: GO:0061341
name: non-canonical Wnt signaling pathway involved in heart development
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors other than beta-catenin and contributing to the progression of the heart over time." [GOC:dph, GOC:mtg_heart, PMID:16860783]
synonym: "non-canonical Wnt receptor signaling pathway involved in heart development" EXACT []
synonym: "non-canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:mah]
synonym: "non-canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:signaling]
is_a: GO:0003306 ! Wnt signaling pathway involved in heart development
is_a: GO:0035567 ! non-canonical Wnt signaling pathway
intersection_of: GO:0035567 ! non-canonical Wnt signaling pathway
intersection_of: part_of GO:0007507 ! heart development
relationship: part_of GO:0007507 ! heart development
created_by: dph
creation_date: 2010-09-29T11:27:34Z

[Term]
id: GO:0061342
name: regulation of cell adhesion involved in heart morphogenesis by non-canonical Wnt signaling pathway
namespace: biological_process
def: "Any process that decreased the extent of cell adhesion that contributes to the shaping of the heart." [PMID:16860783]
synonym: "regulation of cell adhesion involved in heart morphogenesis by non-canonical Wnt signalling pathway" EXACT [GOC:mah]
is_a: GO:0061341 ! non-canonical Wnt signaling pathway involved in heart development
is_a: GO:0061344 ! regulation of cell adhesion involved in heart morphogenesis
created_by: dph
creation_date: 2010-09-29T11:30:15Z

[Term]
id: GO:0061343
name: cell adhesion involved in heart morphogenesis
namespace: biological_process
def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the shaping of the heart." [GOC:dph, GOC:mtg_heart, PMID:16860783]
is_a: GO:0007155 ! cell adhesion
intersection_of: GO:0007155 ! cell adhesion
intersection_of: part_of GO:0003007 ! heart morphogenesis
relationship: part_of GO:0003007 ! heart morphogenesis
created_by: dph
creation_date: 2010-09-29T11:34:06Z

[Term]
id: GO:0061344
name: regulation of cell adhesion involved in heart morphogenesis
namespace: biological_process
def: "Any process that modulates the extent of cell adhesion contributing to the shaping of the heart." [GOC:dph, GOC:mtg_heart, PMID:16860783]
is_a: GO:0030155 ! regulation of cell adhesion
is_a: GO:2000826 ! regulation of heart morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061343 ! cell adhesion involved in heart morphogenesis
relationship: regulates GO:0061343 ! cell adhesion involved in heart morphogenesis
created_by: dph
creation_date: 2010-09-29T11:35:27Z

[Term]
id: GO:0061345
name: planar cell polarity pathway involved in cardiac muscle cell fate commitment
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors other than beta-catenin and contributing to a cardioblast being committed to a cardiac muscle cell fate." [GOC:dph, GOC:mtg_heart, PMID:16860783]
is_a: GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway
is_a: GO:0061341 ! non-canonical Wnt signaling pathway involved in heart development
created_by: dph
creation_date: 2010-09-30T12:39:05Z

[Term]
id: GO:0061346
name: planar cell polarity pathway involved in heart morphogenesis
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the heart." [GOC:dph, GOC:mtg_heart, PMID:16860783]
is_a: GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway
is_a: GO:0061341 ! non-canonical Wnt signaling pathway involved in heart development
relationship: part_of GO:0003007 ! heart morphogenesis
created_by: dph
creation_date: 2010-09-30T12:47:24Z

[Term]
id: GO:0061347
name: planar cell polarity pathway involved in outflow tract morphogenesis
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the outflow tract." [GOC:dph, GOC:mtg_heart, PMID:19056682]
is_a: GO:0061346 ! planar cell polarity pathway involved in heart morphogenesis
intersection_of: GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway
intersection_of: part_of GO:0003151 ! outflow tract morphogenesis
relationship: part_of GO:0003151 ! outflow tract morphogenesis
created_by: dph
creation_date: 2010-10-01T10:38:56Z

[Term]
id: GO:0061348
name: planar cell polarity pathway involved in ventricular septum morphogenesis
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the ventricular septum." [GOC:dph, GOC:mtg_heart, PMID:19056682]
is_a: GO:0061346 ! planar cell polarity pathway involved in heart morphogenesis
relationship: part_of GO:0060412 ! ventricular septum morphogenesis
created_by: dph
creation_date: 2010-10-01T10:47:49Z

[Term]
id: GO:0061349
name: planar cell polarity pathway involved in cardiac right atrium morphogenesis
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the cardiac right atrium." [GOC:dph, GOC:mtg_heart, PMID:19056682]
is_a: GO:0061346 ! planar cell polarity pathway involved in heart morphogenesis
relationship: part_of GO:0003213 ! cardiac right atrium morphogenesis
created_by: dph
creation_date: 2010-10-01T10:52:01Z

[Term]
id: GO:0061350
name: planar cell polarity pathway involved in cardiac muscle tissue morphogenesis
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the cardiac muscle tissue." [GOC:dph, GOC:mtg_heart, PMID:19056682]
is_a: GO:0061346 ! planar cell polarity pathway involved in heart morphogenesis
relationship: part_of GO:0055008 ! cardiac muscle tissue morphogenesis
created_by: dph
creation_date: 2010-10-01T10:57:33Z

[Term]
id: GO:0061351
name: neural precursor cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of neural precursor cells, resulting in the expansion of a cell population. A neural precursor cell is either a nervous system stem cell or a nervous system progenitor cell." [GOC:dph, GOC:yaf]
is_a: GO:0008283 ! cell proliferation
created_by: dph
creation_date: 2010-10-01T11:06:04Z

[Term]
id: GO:0061352
name: cell chemotaxis involved in Malpighian tubule morphogenesis
namespace: biological_process
def: "The directed movement of the outgrowing Malpighian tubule guided by specific chemical cues/signals. Movement may be towards a guidance cue (positive chemotaxis) or away from it (negative chemotaxis). Guidance contributes to the final positioning of the tubule." [GOC:dph, GOC:mtg_kidney_jan10]
is_a: GO:0060326 ! cell chemotaxis
is_a: GO:0061334 ! cell rearrangement involved in Malpighian tubule morphogenesis
intersection_of: GO:0060326 ! cell chemotaxis
intersection_of: part_of GO:0007443 ! Malpighian tubule morphogenesis
relationship: part_of GO:0007443 ! Malpighian tubule morphogenesis
created_by: dph
creation_date: 2010-10-01T11:57:28Z

[Term]
id: GO:0061353
name: BMP signaling pathway involved in Malpighian tubule cell chemotaxis
namespace: biological_process
def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the directed movement of a Malpighian tubule cell toward a stimulus, thereby contributing to the shaping of the tubule." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135]
synonym: "bone morphogenic protein receptor signalling pathway involved in Malpighian tubule cell chemotaxis" EXACT [GOC:mah]
is_a: GO:0030509 ! BMP signaling pathway
intersection_of: GO:0030509 ! BMP signaling pathway
intersection_of: part_of GO:0061352 ! cell chemotaxis involved in Malpighian tubule morphogenesis
relationship: part_of GO:0061352 ! cell chemotaxis involved in Malpighian tubule morphogenesis
created_by: dph
creation_date: 2010-10-01T12:01:00Z

[Term]
id: GO:0061354
name: planar cell polarity pathway involved in pericardium morphogenesis
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the pericardium." [GOC:dph, GOC:mtg_heart, PMID:19056682]
is_a: GO:0061346 ! planar cell polarity pathway involved in heart morphogenesis
relationship: part_of GO:0003344 ! pericardium morphogenesis
created_by: dph
creation_date: 2010-10-01T03:12:53Z

[Term]
id: GO:0061355
name: Wnt protein secretion
namespace: biological_process
def: "The controlled release of a Wnt protein from a cell." [GOC:bf, PMID:19223472]
is_a: GO:0009306 ! protein secretion
is_a: GO:0023061 ! signal release
created_by: dph
creation_date: 2010-10-08T01:07:48Z

[Term]
id: GO:0061356
name: regulation of Wnt protein secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the controlled release of a Wnt protein from a cell." [GOC:bf, PMID:19223472]
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0023051 ! regulation of signaling
is_a: GO:0050708 ! regulation of protein secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061355 ! Wnt protein secretion
relationship: regulates GO:0061355 ! Wnt protein secretion
created_by: dph
creation_date: 2010-10-08T01:09:51Z

[Term]
id: GO:0061357
name: positive regulation of Wnt protein secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the controlled release of a Wnt protein from a cell." [GOC:bf, PMID:19223472]
is_a: GO:0010647 ! positive regulation of cell communication
is_a: GO:0023056 ! positive regulation of signaling
is_a: GO:0050714 ! positive regulation of protein secretion
is_a: GO:0061356 ! regulation of Wnt protein secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061355 ! Wnt protein secretion
relationship: positively_regulates GO:0061355 ! Wnt protein secretion
created_by: dph
creation_date: 2010-10-08T01:12:21Z

[Term]
id: GO:0061358
name: negative regulation of Wnt protein secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a Wnt protein from a cell." [GOC:bf, PMID:19223472]
is_a: GO:0010648 ! negative regulation of cell communication
is_a: GO:0023057 ! negative regulation of signaling
is_a: GO:0050709 ! negative regulation of protein secretion
is_a: GO:0061356 ! regulation of Wnt protein secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061355 ! Wnt protein secretion
relationship: negatively_regulates GO:0061355 ! Wnt protein secretion
created_by: dph
creation_date: 2010-10-08T01:15:15Z

[Term]
id: GO:0061359
name: regulation of Wnt signaling pathway by Wnt protein secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the activity of the Wnt signaling pathway by the controlled release of a Wnt protein from a cell." [GOC:bf, GOC:jl, PMID:19223472]
synonym: "regulation of Wnt receptor signaling pathway by Wnt protein secretion" EXACT []
synonym: "regulation of Wnt receptor signalling pathway by Wnt protein secretion" EXACT [GOC:mah]
synonym: "regulation of Wnt-activated signaling pathway by Wnt protein secretion" EXACT [GOC:signaling]
is_a: GO:0030111 ! regulation of Wnt signaling pathway
is_a: GO:0061355 ! Wnt protein secretion
intersection_of: GO:0061355 ! Wnt protein secretion
intersection_of: regulates GO:0016055 ! Wnt signaling pathway
relationship: regulates GO:0016055 ! Wnt signaling pathway
created_by: dph
creation_date: 2010-10-08T01:18:02Z

[Term]
id: GO:0061360
name: optic chiasma development
namespace: biological_process
def: "The developmental process pertaining to the progression of the optic chiasm from its initial formation to the mature structure. The process begins when the pathfinding of the axons of the developing optic nerve cause some axons to cross at the midline of the brain and ends when the axons are mature." [GOC:dph]
synonym: "optic chiasm development" EXACT [GOC:dph]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021554 ! optic nerve development
created_by: dph
creation_date: 2010-10-13T08:00:29Z

[Term]
id: GO:0061361
name: positive regulation of maintenance of bipolar cell polarity regulating cell shape
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of maintenance of bipolar cell polarity regulating cell shape." [GOC:dph]
is_a: GO:2000115 ! regulation of maintenance of bipolar cell polarity regulating cell shape
is_a: GO:2000247 ! positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape
relationship: positively_regulates GO:0061305 ! maintenance of bipolar cell polarity regulating cell shape
created_by: dph
creation_date: 2010-10-13T09:00:59Z

[Term]
id: GO:0061362
name: negative regulation of maintenance of bipolar cell polarity regulating cell shape
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of maintenance of bipolar cell polarity regulating cell shape." [GOC:dph]
is_a: GO:2000115 ! regulation of maintenance of bipolar cell polarity regulating cell shape
is_a: GO:2000750 ! negative regulation of establishment or maintenance of bipolar cell polarity regulating cell shape
relationship: negatively_regulates GO:0061305 ! maintenance of bipolar cell polarity regulating cell shape
created_by: dph
creation_date: 2010-10-13T09:03:42Z

[Term]
id: GO:0061363
name: negative regulation of progesterone biosynthesis involved in luteolysis
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the biosynthesis of progesterone biosynthesis that contributes to luteolysis." [GOC:dph]
synonym: "functional luteolysis" EXACT [GOC:dph]
is_a: GO:0022414 ! reproductive process
is_a: GO:2000183 ! negative regulation of progesterone biosynthetic process
intersection_of: GO:2000183 ! negative regulation of progesterone biosynthetic process
intersection_of: part_of GO:0001554 ! luteolysis
relationship: negatively_regulates GO:0006701 ! progesterone biosynthetic process
relationship: part_of GO:0001554 ! luteolysis
created_by: dph
creation_date: 2010-10-14T03:08:41Z

[Term]
id: GO:0061364
name: apoptotic process involved in luteolysis
namespace: biological_process
def: "The apoptotic process that contributes to luteolysis." [GOC:mtg_apoptosis, PMID:18566128]
synonym: "apoptosis involved in luteolysis" NARROW []
synonym: "structural luteolysis" EXACT [GOC:dph]
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0022602 ! ovulation cycle process
is_a: GO:1902742 ! apoptotic process involved in development
intersection_of: GO:0006915 ! apoptotic process
intersection_of: part_of GO:0001554 ! luteolysis
relationship: part_of GO:0001554 ! luteolysis
created_by: dph
creation_date: 2010-10-14T03:18:49Z

[Term]
id: GO:0061365
name: positive regulation of triglyceride lipase activity
namespace: biological_process
def: "Any process that increases the activity of triglyceride lipase." [GOC:dph]
is_a: GO:0060193 ! positive regulation of lipase activity
intersection_of: GO:0065009 ! regulation of molecular function
intersection_of: positively_regulates GO:0004806 ! triglyceride lipase activity
relationship: positively_regulates GO:0004806 ! triglyceride lipase activity
created_by: dph
creation_date: 2010-10-15T08:27:22Z

[Term]
id: GO:0061366
name: behavioral response to chemical pain
namespace: biological_process
def: "Any process that results in a change in the behaviour of an organism as a result of a chemical pain stimulus." [GOC:dph]
is_a: GO:0007635 ! chemosensory behavior
is_a: GO:0048266 ! behavioral response to pain
created_by: dph
creation_date: 2010-10-21T03:25:01Z

[Term]
id: GO:0061367
name: behavioral response to acetic acid induced pain
namespace: biological_process
def: "Any process that results in a change in the behaviour of an organism as a result of an acetic acid pain stimulus." [GOC:dph]
is_a: GO:0061366 ! behavioral response to chemical pain
created_by: dph
creation_date: 2010-10-21T03:26:31Z

[Term]
id: GO:0061368
name: behavioral response to formalin induced pain
namespace: biological_process
def: "Any process that results in a change in the behaviour of an organism as a result of a formalin pain stimulus." [GOC:dph]
is_a: GO:0061366 ! behavioral response to chemical pain
created_by: dph
creation_date: 2010-10-21T03:29:48Z

[Term]
id: GO:0061369
name: negative regulation of testicular blood vessel morphogenesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel morphogenesis in the testicle." [GOC:BHF, GOC:dph]
synonym: "negative regulation of testicular vasculature morphogenesis" BROAD [GOC:BHF, GOC:dph]
is_a: GO:2000181 ! negative regulation of blood vessel morphogenesis
created_by: dph
creation_date: 2010-10-27T02:47:14Z

[Term]
id: GO:0061370
name: testosterone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of testosterone, an androgen having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4 C-5." [GOC:dph, GOC:yaf]
is_a: GO:0006702 ! androgen biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0046165 ! alcohol biosynthetic process
created_by: dph
creation_date: 2010-10-27T02:50:48Z

[Term]
id: GO:0061371
name: determination of heart left/right asymmetry
namespace: biological_process
def: "Determination of the asymmetric location of the heart with respect to the left and right halves of the organism." [GOC:dph, GOC:mtg_heart]
synonym: "determination of cardiac left/right asymmetry" EXACT [GOC:dph]
is_a: GO:0007368 ! determination of left/right symmetry
relationship: part_of GO:0007507 ! heart development
created_by: dph
creation_date: 2010-11-03T02:13:58Z

[Term]
id: GO:0061372
name: activin receptor signaling pathway involved in heart jogging
namespace: biological_process
def: "A series of molecular signals initiated by the binding of a member of the activin family to a receptor on the surface of a target cell, and contributing to the process of heart jogging." [GOC:dph, GOC:mtg_heart, GOC:signaling]
synonym: "activin receptor signalling pathway involved in heart jogging" EXACT [GOC:mah]
is_a: GO:0032924 ! activin receptor signaling pathway
is_a: GO:0061311 ! cell surface receptor signaling pathway involved in heart development
intersection_of: GO:0032924 ! activin receptor signaling pathway
intersection_of: part_of GO:0003146 ! heart jogging
relationship: part_of GO:0003146 ! heart jogging
created_by: dph
creation_date: 2010-11-03T02:24:46Z

[Term]
id: GO:0061373
name: mammillary axonal complex development
namespace: biological_process
def: "The progression of the mammillary axonal complex over time, from its formation to the mature structure. The mammillary axonal complex is formed by the axons from the lateral, medial mammillary and the dorsal premammillary nuclei which share a branching pattern. Every neuron gives off one axonal stem that bifurcates into 2 branches. One of the branches is directed dorsally to the thalamus and another caudally to the midbrain." [GOC:dph, GOC:yaf, PMID:10662642]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021767 ! mammillary body development
created_by: dph
creation_date: 2010-11-09T08:49:59Z

[Term]
id: GO:0061374
name: mammillothalamic axonal tract development
namespace: biological_process
def: "The progression of the mammillothalamic axonal tract, from its formation to the mature structure. The mammillothalamic tract is the collection of axons that connects the two major subdivisions of the diencephalon (hypothalamus and thalamus) and closes the diencephalic circuit." [GOC:dph, GOC:yaf, PMID:10662642]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0061373 ! mammillary axonal complex development
created_by: dph
creation_date: 2010-11-09T08:54:43Z

[Term]
id: GO:0061375
name: mammillotectal axonal tract development
namespace: biological_process
def: "The progression of the mammillotectal tract over time, from its formation to the mature structure. The mammillotectal tract is the collection of axons that connects the ventral diencephalon to the superior colliculus." [GOC:dph, GOC:yaf, PMID:10662642]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0061373 ! mammillary axonal complex development
created_by: dph
creation_date: 2010-11-09T09:01:14Z

[Term]
id: GO:0061376
name: mammillotegmental axonal tract development
namespace: biological_process
def: "The process in which the mammillotegmental tract progresses over time, from its formation to the mature structure. The mammillotegmental tract is the collection of axons that connects the ventral diencephalon to the tegmentum and pons." [GOC:dph, GOC:yaf, PMID:10662642]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0061373 ! mammillary axonal complex development
created_by: dph
creation_date: 2010-11-09T09:09:29Z

[Term]
id: GO:0061377
name: mammary gland lobule development
namespace: biological_process
def: "The progression of the mammary gland lobule over time, from its formation to the mature structure. A mammary gland lobule is a small rounded projection of the mammary gland." [GOC:dph, GOC:yaf]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0030879 ! mammary gland development
created_by: dph
creation_date: 2010-11-09T09:36:29Z

[Term]
id: GO:0061378
name: corpora quadrigemina development
namespace: biological_process
def: "The progression of the corpora quadrigemina over time, from its formation to the mature structure. The corpora quadrigemina is a part of the midbrain that is made up of the superior and inferior colliculi." [GOC:dph, GOC:yaf]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0030901 ! midbrain development
created_by: dph
creation_date: 2010-11-09T09:45:36Z

[Term]
id: GO:0061379
name: inferior colliculus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the inferior colliculus over time, from its formation to the mature structure. The inferior colliculus (IC) (Latin, lower hill) is the principal midbrain nucleus of the auditory pathway and receives input from several more peripheral brainstem nuclei in the auditory pathway, as well as inputs from the auditory cortex. The inferior colliculus has three subdivisions: the central nucleus (CIC), a dorsal cortex (DCIC) by which it is surrounded, and an external cortex (ICX) which is located laterally." [GOC:dph, GOC:yaf]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0061378 ! corpora quadrigemina development
created_by: dph
creation_date: 2010-11-09T09:49:24Z

[Term]
id: GO:0061380
name: superior colliculus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the superior colliculus over time, from its formation to the mature structure. The superior colliculus is also known as the optic tectum or simply tectum and is a paired structure that forms a major component of the vertebrate midbrain." [GOC:dph, GOC:yaf]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0061378 ! corpora quadrigemina development
created_by: dph
creation_date: 2010-11-09T09:51:00Z

[Term]
id: GO:0061381
name: cell migration in diencephalon
namespace: biological_process
def: "The orderly movement of a cell that will reside in the diencephalon." [GOC:dph]
is_a: GO:0021885 ! forebrain cell migration
relationship: part_of GO:0021536 ! diencephalon development
created_by: dph
creation_date: 2010-11-09T09:54:27Z

[Term]
id: GO:0061382
name: Malpighian tubule tip cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a Malpighian tubule tip cell. A Malpighian tubule tip cell is a mitogenic signaling cell that controls the proliferation of its neighboring cells." [GOC:dph, GOC:mtg_kidney_jan10, PMID:7821213]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0072002 ! Malpighian tubule development
created_by: dph
creation_date: 2010-11-23T09:52:44Z

[Term]
id: GO:0061383
name: trabecula morphogenesis
namespace: biological_process
def: "The process of shaping a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue." [GOC:dph]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
created_by: dph
creation_date: 2010-12-02T08:51:45Z

[Term]
id: GO:0061384
name: heart trabecula morphogenesis
namespace: biological_process
def: "The process of shaping a trabecula in the heart. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue." [GOC:dph]
is_a: GO:0061383 ! trabecula morphogenesis
created_by: dph
creation_date: 2010-12-02T08:54:20Z

[Term]
id: GO:0061385
name: fibroblast proliferation involved in heart morphogenesis
namespace: biological_process
def: "The multiplication or reproduction of fibroblasts, resulting in the expansion of a fibroblast population that contributes to the shaping of the heart." [GOC:dph]
is_a: GO:0048144 ! fibroblast proliferation
is_a: GO:0061323 ! cell proliferation involved in heart morphogenesis
intersection_of: GO:0048144 ! fibroblast proliferation
intersection_of: part_of GO:0003007 ! heart morphogenesis
relationship: part_of GO:0003007 ! heart morphogenesis
created_by: dph
creation_date: 2011-02-10T01:41:59Z

[Term]
id: GO:0061386
name: closure of optic fissure
namespace: biological_process
def: "The closure of the temporary ventral gap in the optic cup that contributes to its shaping." [GOC:dph]
synonym: "closure or choriod fissure" RELATED [GOC:dph]
is_a: GO:0002011 ! morphogenesis of an epithelial sheet
relationship: part_of GO:0002072 ! optic cup morphogenesis involved in camera-type eye development
created_by: dph
creation_date: 2011-03-30T08:14:59Z

[Term]
id: GO:0061387
name: regulation of extent of cell growth
namespace: biological_process
def: "Any process that modulates the extent of cell growth." [GOC:mah, GOC:vw]
is_a: GO:0001558 ! regulation of cell growth
relationship: part_of GO:0008361 ! regulation of cell size
created_by: dph
creation_date: 2011-07-14T10:15:42Z

[Term]
id: GO:0061388
name: regulation of rate of cell growth
namespace: biological_process
def: "Any process that modulates the rate of cell growth." [GOC:mah, GOC:vw]
is_a: GO:0001558 ! regulation of cell growth
created_by: dph
creation_date: 2011-07-14T10:18:06Z

[Term]
id: GO:0061389
name: regulation of direction of cell growth
namespace: biological_process
def: "Any process that modulates the direction of cell growth." [GOC:mah, GOC:vw]
is_a: GO:0001558 ! regulation of cell growth
is_a: GO:0008360 ! regulation of cell shape
created_by: dph
creation_date: 2011-07-14T10:19:46Z

[Term]
id: GO:0061390
name: positive regulation of direction of cell growth
namespace: biological_process
def: "Any process that increases the direction of cell growth." [GOC:mah, GOC:vw]
is_a: GO:0030307 ! positive regulation of cell growth
is_a: GO:0061389 ! regulation of direction of cell growth
created_by: dph
creation_date: 2011-07-14T10:22:55Z

[Term]
id: GO:0061391
name: negative regulation of direction of cell growth
namespace: biological_process
def: "Any process that decreases the direction of cell growth." [GOC:mah, GOC:vw]
is_a: GO:0030308 ! negative regulation of cell growth
is_a: GO:0061389 ! regulation of direction of cell growth
created_by: dph
creation_date: 2011-07-14T10:25:55Z

[Term]
id: GO:0061392
name: regulation of transcription from RNA polymerase II promoter in response to osmotic stress
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:dph, PMID:12086627, PMID:9858577]
is_a: GO:0043618 ! regulation of transcription from RNA polymerase II promoter in response to stress
is_a: GO:0071470 ! cellular response to osmotic stress
created_by: dph
creation_date: 2011-12-13T08:52:04Z

[Term]
id: GO:0061393
name: positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:dph, PMID:12086627, PMID:9858577]
is_a: GO:0036003 ! positive regulation of transcription from RNA polymerase II promoter in response to stress
is_a: GO:0061392 ! regulation of transcription from RNA polymerase II promoter in response to osmotic stress
created_by: dph
creation_date: 2011-12-13T08:58:20Z

[Term]
id: GO:0061394
name: regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance
namespace: biological_process
def: "Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides." [GOC:dph]
is_a: GO:0043618 ! regulation of transcription from RNA polymerase II promoter in response to stress
relationship: part_of GO:0071243 ! cellular response to arsenic-containing substance
created_by: dph
creation_date: 2011-12-14T08:48:36Z

[Term]
id: GO:0061395
name: positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides." [GOC:dph]
is_a: GO:0036003 ! positive regulation of transcription from RNA polymerase II promoter in response to stress
is_a: GO:0061394 ! regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance
is_a: GO:1901522 ! positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
created_by: dph
creation_date: 2011-12-14T08:53:20Z

[Term]
id: GO:0061396
name: regulation of transcription from RNA polymerase II promoter in response to copper ion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to an copper ion stimulus." [GOC:dph]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
relationship: part_of GO:0071280 ! cellular response to copper ion
created_by: dph
creation_date: 2012-01-10T09:07:08Z

[Term]
id: GO:0061397
name: positive regulation of transcription from RNA polymerase II promoter in response to copper ion
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to an copper ion stimulus." [GOC:dph]
is_a: GO:0061396 ! regulation of transcription from RNA polymerase II promoter in response to copper ion
is_a: GO:1901522 ! positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
created_by: dph
creation_date: 2012-01-10T09:14:51Z

[Term]
id: GO:0061398
name: negative regulation of transcription from RNA polymerase II promoter in response to copper ion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to an copper ion stimulus." [GOC:dph]
is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
is_a: GO:0061396 ! regulation of transcription from RNA polymerase II promoter in response to copper ion
created_by: dph
creation_date: 2012-01-10T09:17:02Z

[Term]
id: GO:0061399
name: positive regulation of transcription from RNA polymerase II promoter in response to cobalt ion
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to a cobalt ion stimulus." [GOC:dph]
is_a: GO:1901522 ! positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
relationship: part_of GO:0071279 ! cellular response to cobalt ion
created_by: dph
creation_date: 2012-01-10T09:28:52Z

[Term]
id: GO:0061400
name: positive regulation of transcription from RNA polymerase II promoter in response to calcium ion
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to a calcium ion stimulus." [GOC:dph]
is_a: GO:1901522 ! positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
relationship: part_of GO:0071277 ! cellular response to calcium ion
created_by: dph
creation_date: 2012-01-10T09:36:02Z

[Term]
id: GO:0061401
name: positive regulation of transcription from RNA polymerase II promoter in response to a hypotonic environment
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of detection of, or exposure to, a decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:dph]
is_a: GO:0061393 ! positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress
is_a: GO:0071476 ! cellular hypotonic response
created_by: dph
creation_date: 2012-01-10T09:43:08Z

[Term]
id: GO:0061402
name: positive regulation of transcription from RNA polymerase II promoter in response to acidic pH
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a pH stimulus with pH < 7." [GOC:dph, GOC:go_curators]
synonym: "positive regulation of transcription from RNA polymerase II promoter in response to acidity" BROAD []
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
is_a: GO:0071468 ! cellular response to acidic pH
created_by: dph
creation_date: 2012-01-10T03:06:32Z

[Term]
id: GO:0061403
name: positive regulation of transcription from RNA polymerase II promoter in response to nitrosative stress
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions." [GOC:dph]
is_a: GO:0036003 ! positive regulation of transcription from RNA polymerase II promoter in response to stress
is_a: GO:0071500 ! cellular response to nitrosative stress
created_by: dph
creation_date: 2012-01-10T03:15:30Z

[Term]
id: GO:0061404
name: positive regulation of transcription from RNA polymerase II promoter in response to increased salt
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:dph]
is_a: GO:0036251 ! positive regulation of transcription from RNA polymerase II promoter in response to salt stress
is_a: GO:0071475 ! cellular hyperosmotic salinity response
created_by: dph
creation_date: 2012-01-10T03:20:40Z

[Term]
id: GO:0061405
name: positive regulation of transcription from RNA polymerase II promoter in response to hydrostatic pressure
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hydrostatic pressure stimulus. Hydrostatic pressure is the force acting on an object in a system where the fluid is at rest (as opposed to moving). The weight of the fluid above the object creates pressure on it." [GOC:dph]
is_a: GO:0036003 ! positive regulation of transcription from RNA polymerase II promoter in response to stress
is_a: GO:1901522 ! positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
relationship: part_of GO:0071464 ! cellular response to hydrostatic pressure
created_by: dph
creation_date: 2012-01-10T03:24:51Z

[Term]
id: GO:0061406
name: positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of glucose." [GOC:dph]
is_a: GO:0036003 ! positive regulation of transcription from RNA polymerase II promoter in response to stress
is_a: GO:0042149 ! cellular response to glucose starvation
created_by: dph
creation_date: 2012-01-12T11:16:10Z

[Term]
id: GO:0061407
name: positive regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hydrogen peroxide (H2O2) stimulus." [GOC:dph]
is_a: GO:0036091 ! positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress
relationship: part_of GO:0070301 ! cellular response to hydrogen peroxide
created_by: dph
creation_date: 2012-01-12T11:39:10Z

[Term]
id: GO:0061408
name: positive regulation of transcription from RNA polymerase II promoter in response to heat stress
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:dph]
is_a: GO:0034605 ! cellular response to heat
is_a: GO:0036003 ! positive regulation of transcription from RNA polymerase II promoter in response to stress
created_by: dph
creation_date: 2012-01-12T11:50:30Z

[Term]
id: GO:0061409
name: positive regulation of transcription from RNA polymerase II promoter in response to freezing
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a freezing stimulus, temperatures below 0 degrees Celsius." [GOC:dph]
is_a: GO:0061411 ! positive regulation of transcription from RNA polymerase II promoter in response to cold
is_a: GO:0071497 ! cellular response to freezing
created_by: dph
creation_date: 2012-01-12T12:11:06Z

[Term]
id: GO:0061410
name: positive regulation of transcription from RNA polymerase II promoter in response to ethanol
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an ethanol stimulus." [GOC:dph]
is_a: GO:1901522 ! positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
relationship: part_of GO:0071361 ! cellular response to ethanol
created_by: dph
creation_date: 2012-01-12T12:17:35Z

[Term]
id: GO:0061411
name: positive regulation of transcription from RNA polymerase II promoter in response to cold
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism." [GOC:dph]
is_a: GO:0036003 ! positive regulation of transcription from RNA polymerase II promoter in response to stress
is_a: GO:0070417 ! cellular response to cold
created_by: dph
creation_date: 2012-01-12T12:31:33Z

[Term]
id: GO:0061412
name: positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of amino acids." [GOC:dph]
is_a: GO:0034198 ! cellular response to amino acid starvation
is_a: GO:0036003 ! positive regulation of transcription from RNA polymerase II promoter in response to stress
created_by: dph
creation_date: 2012-01-12T12:54:05Z

[Term]
id: GO:0061413
name: regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source
namespace: biological_process
def: "A transcription regulation process in which the presence of a nonfermentable carbon source leads to the modulation of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources." [GOC:dph, PMID:19686338]
is_a: GO:0000429 ! carbon catabolite regulation of transcription from RNA polymerase II promoter
created_by: dph
creation_date: 2012-01-23T11:13:06Z

[Term]
id: GO:0061414
name: positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source
namespace: biological_process
def: "A transcription regulation process in which the presence of a nonfermentable carbon source leads to an increase of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources." [GOC:dph, PMID:19686338]
is_a: GO:0000436 ! carbon catabolite activation of transcription from RNA polymerase II promoter
is_a: GO:0061413 ! regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source
created_by: dph
creation_date: 2012-01-23T11:31:27Z

[Term]
id: GO:0061415
name: negative regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source
namespace: biological_process
def: "A transcription regulation process in which the presence of a nonfermentable carbon source leads to a decrease of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources." [GOC:dph, PMID:19686338]
is_a: GO:0000437 ! carbon catabolite repression of transcription from RNA polymerase II promoter
is_a: GO:0061413 ! regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source
created_by: dph
creation_date: 2012-01-23T11:33:08Z

[Term]
id: GO:0061416
name: regulation of transcription from RNA polymerase II promoter in response to salt stress
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under salt stress. The stress is usually an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:dph, PMID:18667581]
is_a: GO:0061392 ! regulation of transcription from RNA polymerase II promoter in response to osmotic stress
is_a: GO:0071472 ! cellular response to salt stress
created_by: dph
creation_date: 2012-01-23T12:56:36Z

[Term]
id: GO:0061417
name: negative regulation of transcription from RNA polymerase II promoter in response to oxidative stress
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:dph, PMID:9767597]
is_a: GO:0043619 ! regulation of transcription from RNA polymerase II promoter in response to oxidative stress
is_a: GO:0097201 ! negative regulation of transcription from RNA polymerase II promoter in response to stress
created_by: dph
creation_date: 2012-01-23T01:02:10Z

[Term]
id: GO:0061418
name: regulation of transcription from RNA polymerase II promoter in response to hypoxia
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus." [GOC:dph, PMID:12511571]
is_a: GO:0043618 ! regulation of transcription from RNA polymerase II promoter in response to stress
relationship: part_of GO:0071456 ! cellular response to hypoxia
created_by: dph
creation_date: 2012-01-23T01:05:59Z

[Term]
id: GO:0061419
name: positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus." [GOC:dph]
is_a: GO:0036003 ! positive regulation of transcription from RNA polymerase II promoter in response to stress
is_a: GO:0061418 ! regulation of transcription from RNA polymerase II promoter in response to hypoxia
is_a: GO:1901522 ! positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
created_by: dph
creation_date: 2012-01-23T01:07:43Z

[Term]
id: GO:0061420
name: regulation of transcription from RNA polymerase II promoter in response to biotin starvation
namespace: biological_process
def: "Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of biotin." [GOC:dph, PMID:16533810]
is_a: GO:0009267 ! cellular response to starvation
is_a: GO:0043618 ! regulation of transcription from RNA polymerase II promoter in response to stress
created_by: dph
creation_date: 2012-01-25T09:55:39Z

[Term]
id: GO:0061421
name: positive regulation of transcription by oleic acid
namespace: biological_process
def: "Any process involving oleic acid that activates or increases the rate of transcription." [GOC:dph, PMID:20395639]
is_a: GO:0045991 ! carbon catabolite activation of transcription
created_by: dph
creation_date: 2012-01-25T10:11:39Z

[Term]
id: GO:0061422
name: positive regulation of transcription from RNA polymerase II promoter in response to alkaline pH
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a pH >7.0." [GOC:dph, PMID:11523797, PMID:15299026, PMID:21749328]
synonym: "positive regulation of transcription from RNA polymerase II promoter in response to alkalinity" BROAD []
is_a: GO:0036003 ! positive regulation of transcription from RNA polymerase II promoter in response to stress
is_a: GO:0071469 ! cellular response to alkaline pH
created_by: dph
creation_date: 2012-01-26T12:42:21Z

[Term]
id: GO:0061423
name: positive regulation of sodium ion transport by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter resulting in the increased frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, PMID:11523797]
is_a: GO:0010765 ! positive regulation of sodium ion transport
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
intersection_of: positively_regulates GO:0006814 ! sodium ion transport
relationship: positively_regulates GO:0006814 ! sodium ion transport
created_by: dph
creation_date: 2012-01-26T12:52:05Z

[Term]
id: GO:0061424
name: positive regulation of peroxisome organization by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter and activates or increases the frequency, rate or extent of peroxisome organization." [GOC:dph, PMID:7500953]
synonym: "positive regulation of peroxisome organisation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:mah]
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
is_a: GO:1900064 ! positive regulation of peroxisome organization
intersection_of: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
intersection_of: positively_regulates GO:0007031 ! peroxisome organization
relationship: positively_regulates GO:0007031 ! peroxisome organization
created_by: dph
creation_date: 2012-02-02T12:50:36Z

[Term]
id: GO:0061425
name: positive regulation of ethanol catabolic process by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter and activates or increases the frequency, rate or extent of an ethanol catabolic process." [GOC:dph, PMID:10608811, PMID:7760841]
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
is_a: GO:1900066 ! positive regulation of ethanol catabolic process
intersection_of: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
intersection_of: positively_regulates GO:0006068 ! ethanol catabolic process
relationship: positively_regulates GO:0006068 ! ethanol catabolic process
created_by: dph
creation_date: 2012-02-02T01:12:36Z

[Term]
id: GO:0061426
name: positive regulation of sulfite transport by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter and activates or increases the frequency, rate or extent of sulfite transport." [GOC:dph, PMID:10234785, PMID:10870099]
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
is_a: GO:1900072 ! positive regulation of sulfite transport
intersection_of: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
intersection_of: positively_regulates GO:0000316 ! sulfite transport
relationship: positively_regulates GO:0000316 ! sulfite transport
created_by: dph
creation_date: 2012-02-02T01:21:46Z

[Term]
id: GO:0061427
name: negative regulation of ceramide biosynthetic process by negative regulation of transcription from RNA Polymerase II promoter
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter and stops, prevents or reduces the frequency, rate or extent of a ceramide biosynthetic process." [GOC:dph, PMID:15302821]
is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
is_a: GO:1900060 ! negative regulation of ceramide biosynthetic process
intersection_of: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
intersection_of: negatively_regulates GO:0046513 ! ceramide biosynthetic process
relationship: negatively_regulates GO:0046513 ! ceramide biosynthetic process
created_by: dph
creation_date: 2012-02-02T01:30:41Z

[Term]
id: GO:0061428
name: negative regulation of transcription from RNA polymerase II promoter in response to hypoxia
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus." [GOC:dph, PMID:17785431]
is_a: GO:0061418 ! regulation of transcription from RNA polymerase II promoter in response to hypoxia
is_a: GO:0097201 ! negative regulation of transcription from RNA polymerase II promoter in response to stress
created_by: dph
creation_date: 2012-02-06T09:26:05Z

[Term]
id: GO:0061429
name: positive regulation of transcription from RNA polymerase II promoter by oleic acid
namespace: biological_process
def: "Any process involving oleic acid that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dph, PMID:20395639]
is_a: GO:0000436 ! carbon catabolite activation of transcription from RNA polymerase II promoter
is_a: GO:0061421 ! positive regulation of transcription by oleic acid
created_by: dph
creation_date: 2012-02-07T09:54:49Z

[Term]
id: GO:0061430
name: bone trabecula morphogenesis
namespace: biological_process
def: "The process of shaping a trabecula in bone. A trabecula is a tissue element in the form of a small beam, strut or rod." [GOC:BHF, GOC:dph, GOC:vk]
is_a: GO:0061383 ! trabecula morphogenesis
created_by: dph
creation_date: 2012-02-07T10:15:36Z

[Term]
id: GO:0061431
name: cellular response to methionine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methionine stimulus." [GOC:dph, PMID:7891681]
is_a: GO:0031670 ! cellular response to nutrient
is_a: GO:0071230 ! cellular response to amino acid stimulus
is_a: GO:1904640 ! response to methionine
created_by: dph
creation_date: 2012-02-07T10:27:01Z

[Term]
id: GO:0061432
name: regulation of transcription from RNA polymerase II promoter in response to methionine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a methionine stimulus." [GOC:dph, PMID:7891681]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
relationship: part_of GO:0061431 ! cellular response to methionine
created_by: dph
creation_date: 2012-02-07T10:33:35Z

[Term]
id: GO:0061433
name: cellular response to caloric restriction
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a of caloric restriction, insufficient food energy intake." [GOC:dph, PMID:17914901]
is_a: GO:0009267 ! cellular response to starvation
created_by: dph
creation_date: 2012-02-09T09:03:15Z

[Term]
id: GO:0061434
name: regulation of replicative cell aging by regulation of transcription from RNA polymerase II promoter in response to caloric restriction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of replicative cell aging through a mechanism that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a caloric restriction stimulus." [GOC:dph, PMID:17914901]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0061433 ! cellular response to caloric restriction
is_a: GO:1900062 ! regulation of replicative cell aging
created_by: dph
creation_date: 2012-02-09T09:06:09Z

[Term]
id: GO:0061435
name: positive regulation of transcription from a mobile element promoter
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transcription from a mobile element promoter." [GOC:dph, PMID:12230120, PMID:9271107]
is_a: GO:0045893 ! positive regulation of transcription, DNA-templated
created_by: dph
creation_date: 2012-02-09T10:01:33Z

[Term]
id: GO:0061436
name: establishment of skin barrier
namespace: biological_process
def: "Establishment of the epithelial barrier, the functional barrier in the skin that limits its permeability." [GOC:dph]
synonym: "epithelial barrier development" RELATED [GOC:dph]
synonym: "establishment of epithelial barrier" BROAD [GOC:dph]
synonym: "skin barrier development" RELATED [GOC:dph]
is_a: GO:0033561 ! regulation of water loss via skin
relationship: part_of GO:0043588 ! skin development
created_by: dph
creation_date: 2012-03-02T09:14:26Z

[Term]
id: GO:0061437
name: renal system vasculature development
namespace: biological_process
def: "The process whose specific outcome is the progression of vasculature of the renal system over time, from its formation to the mature structure." [GOC:dph, GOC:mtg_kidney_jan10, PMID:11891195]
is_a: GO:0001944 ! vasculature development
relationship: part_of GO:0072001 ! renal system development
created_by: dph
creation_date: 2012-03-08T12:16:24Z

[Term]
id: GO:0061438
name: renal system vasculature morphogenesis
namespace: biological_process
def: "The process in which the renal system vasculature is generated and organized. Morphogenesis pertains to the creation of form." [GOC:dph, GOC:mtg_kidney_jan10, PMID:11891195]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0061437 ! renal system vasculature development
created_by: dph
creation_date: 2012-03-08T12:21:56Z

[Term]
id: GO:0061439
name: kidney vasculature morphogenesis
namespace: biological_process
def: "The process in which the kidney vasculature is generated and organized. Morphogenesis pertains to the creation of form." [GOC:dph, GOC:mtg_kidney_jan10]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0061438 ! renal system vasculature morphogenesis
relationship: part_of GO:0061440 ! kidney vasculature development
created_by: dph
creation_date: 2012-03-08T12:30:11Z

[Term]
id: GO:0061440
name: kidney vasculature development
namespace: biological_process
def: "The process whose specific outcome is the progression of the vasculature of the kidney over time, from its formation to the mature structure." [GOC:dph, GOC:mtg_kidney_jan10, PMID:11891195]
is_a: GO:0061437 ! renal system vasculature development
relationship: part_of GO:0001822 ! kidney development
created_by: dph
creation_date: 2012-03-08T12:39:09Z

[Term]
id: GO:0061441
name: renal artery morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of a renal artery is generated and organized. Renal arteries supply the kidneys with blood." [GOC:mtg_kidney_jan10, PMID:11891195]
is_a: GO:0048844 ! artery morphogenesis
relationship: part_of GO:0061439 ! kidney vasculature morphogenesis
created_by: dph
creation_date: 2012-03-08T12:42:09Z

[Term]
id: GO:0061442
name: cardiac muscle cell fate determination
namespace: biological_process
def: "The process involved in cardiac muscle cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [GOC:BHF, GOC:dph]
is_a: GO:0007521 ! muscle cell fate determination
is_a: GO:0060913 ! cardiac cell fate determination
relationship: part_of GO:0060923 ! cardiac muscle cell fate commitment
created_by: dph
creation_date: 2012-03-13T08:59:57Z

[Term]
id: GO:0061443
name: endocardial cushion cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an endocardial cushion cell." [GOC:BHF, GOC:dph]
is_a: GO:0035051 ! cardiocyte differentiation
relationship: part_of GO:0003197 ! endocardial cushion development
created_by: dph
creation_date: 2012-03-13T09:05:38Z

[Term]
id: GO:0061444
name: endocardial cushion cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of an endocardial cushion cell over time, from its formation to the mature state." [GOC:BHF, GOC:dph]
is_a: GO:0055006 ! cardiac cell development
relationship: part_of GO:0061443 ! endocardial cushion cell differentiation
created_by: dph
creation_date: 2012-03-13T09:07:46Z

[Term]
id: GO:0061445
name: endocardial cushion cell fate commitment
namespace: biological_process
def: "The commitment of a cell to an endocardial cushion cell fate and its capacity to differentiate into an endocardial cushion cell." [GOC:BHF, GOC:dph]
is_a: GO:0060957 ! endocardial cell fate commitment
relationship: part_of GO:0061443 ! endocardial cushion cell differentiation
created_by: dph
creation_date: 2012-03-13T09:11:03Z

[Term]
id: GO:0061446
name: endocardial cushion cell fate determination
namespace: biological_process
def: "The process involved in endocardial cushion cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [GOC:BHF, GOC:dph]
is_a: GO:0060913 ! cardiac cell fate determination
relationship: part_of GO:0061445 ! endocardial cushion cell fate commitment
created_by: dph
creation_date: 2012-03-13T09:22:13Z

[Term]
id: GO:0061447
name: endocardial cushion cell fate specification
namespace: biological_process
def: "The process involved in the specification of endocardial cushion cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment." [GOC:BHF, GOC:dph]
is_a: GO:0060912 ! cardiac cell fate specification
relationship: part_of GO:0061445 ! endocardial cushion cell fate commitment
created_by: dph
creation_date: 2012-03-13T09:25:56Z

[Term]
id: GO:0061448
name: connective tissue development
namespace: biological_process
def: "The progression of a connective tissue over time, from its formation to the mature structure." [GOC:BHF]
is_a: GO:0009888 ! tissue development
created_by: dph
creation_date: 2012-03-22T12:53:41Z

[Term]
id: GO:0061449
name: olfactory bulb tufted cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of an olfactory bulb tufted cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph]
is_a: GO:0021954 ! central nervous system neuron development
relationship: part_of GO:0021772 ! olfactory bulb development
created_by: dph
creation_date: 2012-05-15T12:30:21Z

[Term]
id: GO:0061450
name: trophoblast cell migration
namespace: biological_process
def: "Trophoblast cell migration that is accomplished by extension and retraction of a pseudopodium. Trophoblast cells line the outside of the blastocyst." [GOC:dph]
is_a: GO:0001667 ! ameboidal-type cell migration
is_a: GO:0044702 ! single organism reproductive process
relationship: part_of GO:0007566 ! embryo implantation
created_by: dph
creation_date: 2012-07-10T08:38:37Z

[Term]
id: GO:0061451
name: retrotrapezoid nucleus development
namespace: biological_process
def: "The progression of the retrotrapezoid nucleus (RTN) over time from it's initial formation to its mature state. The retrotrapezoid nucleus is a group of neurons in the rostral medulla, which are responsible regulating respiration." [GOC:dph]
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021550 ! medulla oblongata development
created_by: dph
creation_date: 2012-07-19T12:38:30Z

[Term]
id: GO:0061452
name: retrotrapezoid nucleus neuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the retrotrapezoid nucleus." [GOC:dph]
is_a: GO:0021953 ! central nervous system neuron differentiation
relationship: part_of GO:0061451 ! retrotrapezoid nucleus development
created_by: dph
creation_date: 2012-07-19T12:43:18Z

[Term]
id: GO:0061453
name: interstitial cell of Cajal differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an interstitial cell of Cajal. An interstitial cell of Cajal is an intestinal neuroepithelial cell that serves as a pacemaker to trigger gut contraction." [GOC:dph]
synonym: "ICC differentiation" RELATED [GOC:dph]
is_a: GO:0060563 ! neuroepithelial cell differentiation
is_a: GO:0060575 ! intestinal epithelial cell differentiation
created_by: dph
creation_date: 2012-07-20T08:20:50Z

[Term]
id: GO:0061454
name: Golgi calcium ion export
namespace: biological_process
def: "The directed movement of calcium ions (Ca2+) out of the Golgi apparatus into the cytosol." [GOC:dph, GOC:tb]
is_a: GO:0032472 ! Golgi calcium ion transport
is_a: GO:0051209 ! release of sequestered calcium ion into cytosol
is_a: GO:1901660 ! calcium ion export
created_by: dph
creation_date: 2012-07-27T02:29:43Z

[Term]
id: GO:0061455
name: integral component of muscle cell projection membrane
namespace: cellular_component
def: "The component of the muscle cell projection membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:dph, GOC:tb]
synonym: "integral to muscle cell projection membrane" EXACT []
is_a: GO:0005887 ! integral component of plasma membrane
is_a: GO:0044463 ! cell projection part
intersection_of: GO:0016021 ! integral component of membrane
intersection_of: part_of GO:0036195 ! muscle cell projection membrane
relationship: part_of GO:0036195 ! muscle cell projection membrane
created_by: dph
creation_date: 2012-07-27T02:38:01Z

[Term]
id: GO:0061456
name: mesenchymal stem cell migration involved in uteric bud morphogenesis
namespace: biological_process
def: "The orderly movement of a mesenchymal stem cell from one site to another contributing to the shaping of the ureteric bud. A mesenchymal stem cell, or MSC, is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [GOC:dph, GOC:tb]
is_a: GO:0035787 ! cell migration involved in kidney development
relationship: part_of GO:0060675 ! ureteric bud morphogenesis
created_by: dph
creation_date: 2012-08-22T17:19:22Z

[Term]
id: GO:0061457
name: mesonephric cell migration involved in male gonad development
namespace: biological_process
def: "The orderly movement of a cell from the mesonephros to the male gonad, contributing to its development." [GOC:dph, GOC:tb]
is_a: GO:0016477 ! cell migration
created_by: dph
creation_date: 2012-08-22T17:31:00Z

[Term]
id: GO:0061458
name: reproductive system development
namespace: biological_process
def: "The progression of the reproductive system over time from its formation to the mature structure. The reproductive system consists of the organs that function in reproduction." [GOC:dph]
is_a: GO:0048731 ! system development
created_by: dph
creation_date: 2012-08-22T17:47:53Z

[Term]
id: GO:0061459
name: L-arginine transmembrane transporter activity
namespace: molecular_function
def: "Enables the stereospecific transfer of L-arginine, 2-amino-5-guanidinopentanoic acid, across a biological membrane." [GOC:dph]
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity
is_a: GO:0015181 ! arginine transmembrane transporter activity
relationship: part_of GO:1903400 ! L-arginine transmembrane transport
created_by: dph
creation_date: 2012-09-25T08:37:29Z

[Term]
id: GO:0061460
name: L-histidine import
namespace: biological_process
def: "The directed movement of L-histidine into a cell or organelle." [GOC:dph]
is_a: GO:0043092 ! L-amino acid import
is_a: GO:0090466 ! histidine import
is_a: GO:1902024 ! L-histidine transport
created_by: dph
creation_date: 2012-10-05T10:20:50Z

[Term]
id: GO:0061461
name: L-lysine import
namespace: biological_process
def: "The directed movement of L-lysine into a cell or organelle." [GOC:dph]
is_a: GO:0034226 ! lysine import
is_a: GO:0043092 ! L-amino acid import
is_a: GO:1902022 ! L-lysine transport
created_by: dph
creation_date: 2012-10-05T10:22:26Z

[Term]
id: GO:0061462
name: protein localization to lysosome
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a lysosome." [GOC:dph]
is_a: GO:0072665 ! protein localization to vacuole
created_by: dph
creation_date: 2012-10-05T10:50:51Z

[Term]
id: GO:0061463
name: O-acetyl-ADP-ribose deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction O-acetyl-ADP-ribose + H2O = ADP-ribose + acetate." [GOC:dph]
is_a: GO:0019213 ! deacetylase activity
created_by: dph
creation_date: 2012-10-05T11:05:06Z

[Term]
id: GO:0061464
name: plasma membrane part of cell-substrate junction.
namespace: cellular_component
def: "The part of the plasma membrane that contributes to the structure of a cell-substrate junction." [GOC:dph]
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0030055 ! cell-substrate junction
created_by: dph
creation_date: 2012-10-19T11:04:48Z

[Term]
id: GO:0061465
name: plasma membrane part of hemidesmosome
namespace: cellular_component
def: "The part of the plasma membrane that contributes to the structure of a hemidesmosome." [GOC:dph]
is_a: GO:0061464 ! plasma membrane part of cell-substrate junction.
relationship: part_of GO:0009925 ! basal plasma membrane
relationship: part_of GO:0030056 ! hemidesmosome
created_by: dph
creation_date: 2012-10-19T13:47:25Z

[Term]
id: GO:0061466
name: plasma membrane part of cell junction
namespace: cellular_component
def: "The part of the plasma membrane that contributes to the structure of a cell junction." [GOC:dph]
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0030054 ! cell junction
created_by: dph
creation_date: 2012-10-19T13:53:44Z

[Term]
id: GO:0061467
name: basolateral protein localization
namespace: biological_process
def: "Any process in which a protein is transported to, or maintained in, basolateral regions of the cell." [GOC:dph]
is_a: GO:0008105 ! asymmetric protein localization
created_by: dph
creation_date: 2012-10-19T13:58:04Z

[Term]
id: GO:0061468
name: karyomere
namespace: cellular_component
def: "A membrane-bound intermediate cleavage-stage structure of individual or groups of chromosomes that coalesces and fuses with other karyomeres to form a nucleus during interphase. Karyomere formation occurs in blastomeres undergoing rapid cell division." [GOC:dph, PMID:12734396, PMID:22863006]
is_a: GO:0043231 ! intracellular membrane-bounded organelle
created_by: dph
creation_date: 2012-10-22T14:19:29Z

[Term]
id: GO:0061469
name: regulation of type B pancreatic cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of type B pancreatic cell proliferation." [GOC:dph]
is_a: GO:0050678 ! regulation of epithelial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044342 ! type B pancreatic cell proliferation
relationship: regulates GO:0044342 ! type B pancreatic cell proliferation
created_by: dph
creation_date: 2012-11-01T13:16:23Z

[Term]
id: GO:0061470
name: T follicular helper cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized T cell acquires specialized features of a mature T follicular helper cell." [GOC:dph, PMID:21572431]
synonym: "T-helper follicular cell differentiation" EXACT [GOC:dph]
is_a: GO:0042093 ! T-helper cell differentiation
created_by: dph
creation_date: 2012-11-02T09:01:48Z

[Term]
id: GO:0061471
name: karyomere assembly
namespace: biological_process
def: "The process where the nuclear membrane engulfs condensed chromosomes to form karyomeres during M phase of the mitotic cell cycle." [GOC:dph, PMID:9732278]
is_a: GO:0070925 ! organelle assembly
is_a: GO:1902589 ! single-organism organelle organization
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:0007084 ! mitotic nuclear envelope reassembly
created_by: dph
creation_date: 2012-11-02T09:13:59Z

[Term]
id: GO:0061472
name: karyomere membrane fusion
namespace: biological_process
def: "Process whereby karyomere membranes fuse during interphase to form a single lobed nucleus." [GOC:dph, PMID:2734396]
is_a: GO:0090174 ! organelle membrane fusion
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:0007084 ! mitotic nuclear envelope reassembly
created_by: dph
creation_date: 2012-11-02T09:25:41Z

[Term]
id: GO:0061473
name: murein tripeptide carboxypeptidase activity
namespace: molecular_function
def: "Catalysis of the reaction L-Ala-gamma;-D-Glu-meso-Dap (murein tripeptide) + H2O = L-Ala-&gamma;-D-Glu + meso-diaminopimelate." [GOC:dph, PMID:22970852]
is_a: GO:0004181 ! metallocarboxypeptidase activity
created_by: dph
creation_date: 2012-11-06T12:23:39Z

[Term]
id: GO:0061474
name: phagolysosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a phagolysosome." [GOC:dph, PMID:22073313]
is_a: GO:0005765 ! lysosomal membrane
is_a: GO:0030670 ! phagocytic vesicle membrane
relationship: part_of GO:0032010 ! phagolysosome
created_by: dph
creation_date: 2012-11-06T12:26:18Z

[Term]
id: GO:0061475
name: cytosolic valyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling valine to valyl-tRNA in the cytosol, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:dph]
is_a: GO:0006438 ! valyl-tRNA aminoacylation
intersection_of: GO:0006438 ! valyl-tRNA aminoacylation
intersection_of: occurs_in GO:0005829 ! cytosol
relationship: occurs_in GO:0005829 ! cytosol
created_by: dph
creation_date: 2012-11-06T12:29:42Z

[Term]
id: GO:0061476
name: response to anticoagulant
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anticoagulant stimulus." [GOC:dph]
is_a: GO:0042493 ! response to drug
created_by: dph
creation_date: 2012-11-07T09:07:00Z

[Term]
id: GO:0061477
name: response to aromatase inhibitor
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aromatase inhibitor stimulus." [GOC:dph]
is_a: GO:0042221 ! response to chemical
created_by: dph
creation_date: 2012-11-07T09:08:36Z

[Term]
id: GO:0061478
name: response to platelet aggregation inhibitor
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet aggregation inhibitor stimulus." [GOC:dph]
is_a: GO:0042493 ! response to drug
created_by: dph
creation_date: 2012-11-07T09:09:37Z

[Term]
id: GO:0061479
name: response to reverse transcriptase inhibitor
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reverse transcriptase inhibitor stimulus." [GOC:dph]
is_a: GO:0042221 ! response to chemical
created_by: dph
creation_date: 2012-11-07T09:10:51Z

[Term]
id: GO:0061480
name: response to asparaginase
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an asparaginase stimulus." [GOC:dph]
is_a: GO:0042221 ! response to chemical
created_by: dph
creation_date: 2012-11-07T09:13:08Z

[Term]
id: GO:0061481
name: response to TNF agonist
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a TNF agonist stimulus." [GOC:dph]
is_a: GO:0042221 ! response to chemical
created_by: dph
creation_date: 2012-11-07T09:14:07Z

[Term]
id: GO:0061482
name: response to irinotecan
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an irinotecan stimulus." [GOC:dph]
is_a: GO:0042221 ! response to chemical
created_by: dph
creation_date: 2012-11-07T09:15:03Z

[Term]
id: GO:0061483
name: sulfinylpropanyl adenylate synthase
namespace: molecular_function
def: "Catalysis of the reaction: cysteine sulfanate + GTP + IMP = sulfinylpropanyl adenylate + GDP + 3 H(+) + phosphate." [GOC:dph, PMID:8346915]
synonym: "SPA synthase" RELATED [PMID:8346915]
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds
created_by: dph
creation_date: 2012-11-16T10:08:15Z

[Term]
id: GO:0061484
name: hematopoietic stem cell homeostasis
namespace: biological_process
def: "Any biological process involved in the maintenance of the steady-state number of hematopoietic stem cells within a population of cells." [GOC:dph, PMID:21508411]
is_a: GO:0048872 ! homeostasis of number of cells
created_by: dph
creation_date: 2012-12-04T09:41:02Z

[Term]
id: GO:0061485
name: memory T cell proliferation
namespace: biological_process
def: "The expansion of a memory T cell population by cell division." [GOC:dph, PMID:14647273]
is_a: GO:0042098 ! T cell proliferation
created_by: dph
creation_date: 2012-12-04T09:52:54Z

[Term]
id: GO:0061486
name: high-affinity fructose transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of fructose from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:dph, PMID:10735857]
synonym: "high affinity fructose transmembrane transporter activity" EXACT []
is_a: GO:0005353 ! fructose transmembrane transporter activity
created_by: dph
creation_date: 2012-12-04T10:34:55Z

[Term]
id: GO:0061487
name: DNA replication initiation from late origin
namespace: biological_process
def: "The process in which DNA-dependent DNA replication is started at a late origin of replication. A late origin of replication refers to an origin that is activated late in S phase." [GOC:dph, PMID:19221029]
synonym: "late replication origin firing" EXACT [GOC:dph, PMID:19221029]
is_a: GO:0006270 ! DNA replication initiation
created_by: dph
creation_date: 2012-12-06T11:21:48Z

[Term]
id: GO:0061488
name: adenine import into cell
namespace: biological_process
def: "The directed movement of adenine from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [GOC:dph, GOC:mah]
is_a: GO:0015853 ! adenine transport
is_a: GO:0098657 ! import into cell
created_by: dph
creation_date: 2012-12-06T14:51:42Z

[Term]
id: GO:0061489
name: guanine import into cell
namespace: biological_process
def: "The directed movement of guanine from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [GOC:dph, GOC:mah]
is_a: GO:0015854 ! guanine transport
is_a: GO:0098657 ! import into cell
created_by: dph
creation_date: 2012-12-06T14:52:43Z

[Term]
id: GO:0061490
name: glucose import into cell
namespace: biological_process
def: "The directed movement of glucose from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [GOC:dph, GOC:mah]
is_a: GO:0046323 ! glucose import
is_a: GO:0097319 ! carbohydrate import into cell
created_by: dph
creation_date: 2012-12-06T14:54:07Z

[Term]
id: GO:0061491
name: serine import into cell
namespace: biological_process
def: "The directed movement of serine from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [GOC:dph, GOC:mah]
is_a: GO:0090478 ! serine import
is_a: GO:1902837 ! amino acid import into cell
created_by: dph
creation_date: 2012-12-06T14:55:29Z

[Term]
id: GO:0061492
name: asymmetric protein localization to old or new spindle pole body
namespace: biological_process
def: "Any process in which a protein is transported to, or maintained to either the old or new spindle pole body resulting in its being distributed asymmetrically." [GOC:dph, PMID:22119525]
is_a: GO:0008105 ! asymmetric protein localization
is_a: GO:0071988 ! protein localization to spindle pole body
created_by: dph
creation_date: 2012-12-06T15:23:15Z

[Term]
id: GO:0061493
name: central plaque of mitotic spindle pole body
namespace: cellular_component
def: "One of three laminate structures that form the mitotic spindle pole body; the central plaque is embedded in the nuclear envelope." [GOC:dph]
is_a: GO:0005823 ! central plaque of spindle pole body
relationship: part_of GO:0044732 ! mitotic spindle pole body
created_by: dph
creation_date: 2012-12-11T09:08:26Z

[Term]
id: GO:0061494
name: gamma-tubulin large complex, mitotic spindle pole body
namespace: cellular_component
def: "A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes located in the mitotic spindle pole body." [GOC:dph]
is_a: GO:0055032 ! gamma-tubulin large complex, spindle pole body
intersection_of: GO:0000931 ! gamma-tubulin large complex
intersection_of: part_of GO:0044732 ! mitotic spindle pole body
relationship: part_of GO:0044732 ! mitotic spindle pole body
created_by: dph
creation_date: 2012-12-11T09:10:00Z

[Term]
id: GO:0061495
name: gamma-tubulin small complex, mitotic spindle pole body
namespace: cellular_component
def: "A complex composed of two gamma-tubulin molecules and conserved non-tubulin proteins located in the mitotic spindle pole body and isolated by fractionation from cells. The complex, approximately 6S-9S, is analogous to the small complex in animal cells but contains fewer subunits, and is not thought to multimerize into larger functional units, like complexes in those organisms. An example of this structure is found in Saccharomyces cerevisiae." [GOC:dph]
is_a: GO:0000928 ! gamma-tubulin small complex, spindle pole body
intersection_of: GO:0008275 ! gamma-tubulin small complex
intersection_of: part_of GO:0044732 ! mitotic spindle pole body
relationship: part_of GO:0044732 ! mitotic spindle pole body
created_by: dph
creation_date: 2012-12-11T09:11:27Z

[Term]
id: GO:0061496
name: half bridge of mitotic spindle pole body
namespace: cellular_component
def: "Structure adjacent to the plaques of the mitotic spindle pole body." [GOC:dph]
is_a: GO:0005825 ! half bridge of spindle pole body
relationship: part_of GO:0044732 ! mitotic spindle pole body
created_by: dph
creation_date: 2012-12-11T09:13:52Z

[Term]
id: GO:0061497
name: inner plaque of mitotic spindle pole body
namespace: cellular_component
def: "One of three laminate structures that form the mitotic spindle pole body; the inner plaque is in the nucleus." [GOC:dph, GOC:vw]
is_a: GO:0005822 ! inner plaque of spindle pole body
relationship: part_of GO:0044732 ! mitotic spindle pole body
created_by: dph
creation_date: 2012-12-11T09:15:12Z

[Term]
id: GO:0061498
name: intermediate layer of mitotic spindle pole body
namespace: cellular_component
def: "Structure between the central and outer plaques of the mitotic spindle pole body." [GOC:dph]
is_a: GO:0005821 ! intermediate layer of spindle pole body
relationship: part_of GO:0044732 ! mitotic spindle pole body
created_by: dph
creation_date: 2012-12-11T09:17:14Z

[Term]
id: GO:0061499
name: outer plaque of mitotic spindle pole body
namespace: cellular_component
def: "One of three laminate structures that form the mitotic spindle pole body; the outer plaque is in the cytoplasm." [GOC:dph]
is_a: GO:0005824 ! outer plaque of spindle pole body
relationship: part_of GO:0044732 ! mitotic spindle pole body
created_by: dph
creation_date: 2012-12-11T09:18:43Z

[Term]
id: GO:0061500
name: gene conversion at mating-type locus, termination of copy-synthesis
namespace: biological_process
def: "A DNA replication termination process that is part of gene conversion at a mating-type locus and takes place at a specific termination site." [GOC:dph, PMID:10716938]
is_a: GO:0022414 ! reproductive process
is_a: GO:0071170 ! site-specific DNA replication termination
intersection_of: GO:0071170 ! site-specific DNA replication termination
intersection_of: part_of GO:0007534 ! gene conversion at mating-type locus
relationship: part_of GO:0007534 ! gene conversion at mating-type locus
created_by: dph
creation_date: 2012-12-11T09:32:31Z

[Term]
id: GO:0061501
name: cyclic-GMP-AMP synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic GMP-AMP." [GOC:dph, PMID:23258413]
is_a: GO:0016779 ! nucleotidyltransferase activity
created_by: dph
creation_date: 2013-01-04T07:17:57Z

[Term]
id: GO:0061502
name: early endosome to recycling endosome transport
namespace: biological_process
def: "The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the recycling endosomes." [GOC:dph, GOC:kmv, PMID:21474295]
is_a: GO:0016482 ! cytosolic transport
is_a: GO:0098927 ! vesicle-mediated transport between endosomal compartments
relationship: occurs_in GO:0005829 ! cytosol
created_by: dph
creation_date: 2013-01-04T07:24:56Z

[Term]
id: GO:0061503
name: tRNA threonylcarbamoyladenosine dehydratase
namespace: molecular_function
def: "Catalysis of the ATP-dependent dehydration of t6A to form cyclic t6A." [GOC:dph, PMID:23242255]
is_a: GO:0016836 ! hydro-lyase activity
created_by: dph
creation_date: 2013-01-22T14:22:14Z

[Term]
id: GO:0061504
name: cyclic threonylcarbamoyladenosine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cyclic threonylcarbamoyladenosine, a modified nucleoside found in some tRNA molecules." [PMID:23242255]
is_a: GO:0006400 ! tRNA modification
created_by: dph
creation_date: 2013-01-22T14:25:00Z

[Term]
id: GO:0061505
name: DNA topoisomerase II activity
namespace: molecular_function
def: "Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; changes the linking number in multiples of 2." [GOC:dph]
is_a: GO:0003916 ! DNA topoisomerase activity
created_by: dph
creation_date: 2013-01-23T10:40:04Z

[Term]
id: GO:0061506
name: DNA topoisomerase type II (ATP-independent) activity
namespace: molecular_function
def: "Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is not coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2." [GOC:dph]
is_a: GO:0061505 ! DNA topoisomerase II activity
created_by: dph
creation_date: 2013-01-23T10:41:58Z

[Term]
id: GO:0061507
name: cyclic-GMP-AMP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with cyclic-GMP-AMP (cGAMP) cyclic nucleotide." [GOC:dph, PMID:23258412]
is_a: GO:0030551 ! cyclic nucleotide binding
is_a: GO:0032559 ! adenyl ribonucleotide binding
is_a: GO:0032561 ! guanyl ribonucleotide binding
is_a: GO:0043168 ! anion binding
created_by: dph
creation_date: 2013-01-24T15:38:27Z

[Term]
id: GO:0061508
name: CDP phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group into CDP to produce a CTP." [PMID:7499258]
is_a: GO:0006165 ! nucleoside diphosphate phosphorylation
created_by: dph
creation_date: 2013-02-21T13:38:11Z

[Term]
id: GO:0061509
name: asymmetric protein localization to old mitotic spindle pole body
namespace: biological_process
def: "Any process in which a protein is transported to, or maintained to the old mitotic spindle pole body resulting in its being distributed asymmetrically." [GOC:dph, GOC:vw]
is_a: GO:0061492 ! asymmetric protein localization to old or new spindle pole body
is_a: GO:1902440 ! protein localization to mitotic spindle pole body
created_by: dph
creation_date: 2013-02-21T13:49:26Z

[Term]
id: GO:0061510
name: asymmetric protein localization to new mitotic spindle pole body
namespace: biological_process
def: "Any process in which a protein is transported to, or maintained to the new mitotic spindle pole body resulting in its being distributed asymmetrically." [GOC:dph, GOC:vw]
is_a: GO:0061492 ! asymmetric protein localization to old or new spindle pole body
is_a: GO:1902440 ! protein localization to mitotic spindle pole body
created_by: dph
creation_date: 2013-02-21T13:49:54Z

[Term]
id: GO:0061511
name: centriole elongation
namespace: biological_process
def: "The centrosome organization process by which a centriole increases in length as part of the process of replication." [GOC:dph, PMID:21576394]
is_a: GO:0022402 ! cell cycle process
is_a: GO:0051297 ! centrosome organization
is_a: GO:1902589 ! single-organism organelle organization
relationship: part_of GO:0007099 ! centriole replication
created_by: dph
creation_date: 2013-03-22T09:06:27Z

[Term]
id: GO:0061512
name: protein localization to cilium
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a cilium." [GOC:dph]
is_a: GO:0033365 ! protein localization to organelle
created_by: dph
creation_date: 2013-03-22T15:41:44Z

[Term]
id: GO:0061513
name: glucose 6-phosphate:inorganic phosphate antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose 6-phosphate(out) + inorganic phosphate(in) = glucose 6-phosphate(in) + inorganic phosphate(out)." [GOC:dph, PMID:18337460]
is_a: GO:0015526 ! hexose-phosphate:inorganic phosphate antiporter activity
created_by: dph
creation_date: 2013-04-17T08:47:40Z

[Term]
id: GO:0061514
name: interleukin-34-mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of interleukin-34 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:dph, PMID:18467591]
is_a: GO:0019221 ! cytokine-mediated signaling pathway
created_by: dph
creation_date: 2013-04-18T13:00:33Z

[Term]
id: GO:0061515
name: myeloid cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a myeloid cell over time, from its formation to the mature structure." [GOC:dph]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0030099 ! myeloid cell differentiation
created_by: dph
creation_date: 2013-04-18T13:03:16Z

[Term]
id: GO:0061516
name: monocyte proliferation
namespace: biological_process
def: "The expansion of a monocyte population by cell division." [GOC:dph, PMID:18467591]
is_a: GO:0070661 ! leukocyte proliferation
created_by: dph
creation_date: 2013-04-18T13:14:24Z

[Term]
id: GO:0061517
name: macrophage proliferation
namespace: biological_process
def: "The expansion of a macrophage population by cell division." [GOC:dph, PMID:12614284, PMID:19466391]
is_a: GO:0070661 ! leukocyte proliferation
created_by: dph
creation_date: 2013-04-18T13:17:56Z

[Term]
id: GO:0061518
name: microglial cell proliferation
namespace: biological_process
def: "The expansion of a microglial cell population by cell division." [GOC:dph, PMID:17344397]
is_a: GO:0014009 ! glial cell proliferation
is_a: GO:0061517 ! macrophage proliferation
created_by: dph
creation_date: 2013-04-18T13:20:21Z

[Term]
id: GO:0061519
name: macrophage homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of macrophage cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:dph, PMID:21727904]
is_a: GO:0001776 ! leukocyte homeostasis
is_a: GO:0002262 ! myeloid cell homeostasis
created_by: dph
creation_date: 2013-04-18T13:25:33Z

[Term]
id: GO:0061520
name: Langerhans cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a Langerhans cell." [GOC:dph, PMID:22729249]
is_a: GO:0043011 ! myeloid dendritic cell differentiation
created_by: dph
creation_date: 2013-04-18T13:29:07Z

[Term]
id: GO:0061521
name: hepatic stellate cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a hepatic stellate cell." [GOC:dph, PMID:9407545]
is_a: GO:0030154 ! cell differentiation
created_by: dph
creation_date: 2013-04-18T13:36:08Z

[Term]
id: GO:0061522
name: 1,4-dihydroxy-2-naphthoyl-CoA thioesterase activity
namespace: molecular_function
def: "Catalysis of the reaction 1,4-dihydroxy-2-naphthoyl-CoA + H2O = 1,4-dihydroxy-2-naphthoate + CoA." [GOC:dph]
is_a: GO:0016289 ! CoA hydrolase activity
created_by: dph
creation_date: 2013-04-18T14:37:32Z

[Term]
id: GO:0061523
name: cilium disassembly
namespace: biological_process
def: "A cellular process that results in the breakdown of a cilium." [GOC:dph, PMID:17604723]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.
synonym: "cilium resorption" EXACT [GOC:dph]
is_a: GO:0044782 ! cilium organization
is_a: GO:1903008 ! organelle disassembly
created_by: dph
creation_date: 2013-04-18T14:59:59Z

[Term]
id: GO:0061524
name: central canal development
namespace: biological_process
def: "The process whose specific outcome is the formation of the central canal of the spinal cord from its formation to the mature structure. The central canal is a spinal cord structure that is part of the ventricular system and is filled with cerebral-spinal fluid and runs the length of the spinal cord." [GOC:cvs, GOC:dph, PMID:23409159]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021510 ! spinal cord development
created_by: dph
creation_date: 2013-04-20T08:18:31Z

[Term]
id: GO:0061525
name: hindgut development
namespace: biological_process
def: "The process whose specific outcome is the progression of the hindgut over time, from its formation to the mature structure. The hindgut is part of the alimentary canal that lies posterior to the midgut." [GOC:dph]
is_a: GO:0048565 ! digestive tract development
created_by: dph
creation_date: 2013-06-14T11:22:21Z

[Term]
id: GO:0061526
name: acetylcholine secretion
namespace: biological_process
def: "The regulated release of acetylcholine by a cell." [GOC:dph]
is_a: GO:0015870 ! acetylcholine transport
is_a: GO:0032940 ! secretion by cell
created_by: dph
creation_date: 2013-06-21T15:40:39Z

[Term]
id: GO:0061527
name: dopamine secretion, neurotransmission
namespace: biological_process
def: "The regulated release of dopamine by a cell in which the dopamine acts as a neurotransmitter." [GOC:dph]
is_a: GO:0007269 ! neurotransmitter secretion
is_a: GO:0014046 ! dopamine secretion
relationship: part_of GO:0001963 ! synaptic transmission, dopaminergic
created_by: dph
creation_date: 2013-06-21T15:43:15Z

[Term]
id: GO:0061528
name: aspartate secretion
namespace: biological_process
def: "The regulated release of aspartate by a cell." [GOC:dph]
is_a: GO:0015810 ! aspartate transport
is_a: GO:0032940 ! secretion by cell
is_a: GO:0046717 ! acid secretion
created_by: dph
creation_date: 2013-06-21T15:45:37Z

[Term]
id: GO:0061529
name: epinephrine secretion, neurotransmission
namespace: biological_process
def: "The regulated release of epinephrine by a cell in which the epinephrine acts as a neurotransmitter." [GOC:dph]
synonym: "adrenaline secretion, neurotransmission" EXACT [GOC:dph]
is_a: GO:0007269 ! neurotransmitter secretion
is_a: GO:0048242 ! epinephrine secretion
created_by: dph
creation_date: 2013-06-21T15:47:22Z

[Term]
id: GO:0061530
name: aspartate secretion, neurotransmission
namespace: biological_process
def: "The regulated release of aspartate by a cell in which the aspartate acts as a neurotransmitter." [GOC:dph]
is_a: GO:0007269 ! neurotransmitter secretion
is_a: GO:0061528 ! aspartate secretion
created_by: dph
creation_date: 2013-06-21T15:50:10Z

[Term]
id: GO:0061531
name: primary amine secretion
namespace: biological_process
def: "The regulated release of a primary amine by a cell." [GOC:dph]
is_a: GO:0015695 ! organic cation transport
is_a: GO:0015696 ! ammonium transport
is_a: GO:0015837 ! amine transport
is_a: GO:0032940 ! secretion by cell
created_by: dph
creation_date: 2013-06-21T15:56:08Z

[Term]
id: GO:0061532
name: primary amine secretion, neurotransmission
namespace: biological_process
def: "The regulated release of a primary amine by a cell, in which the primary amine acts as a neurotransmitter." [GOC:dph]
is_a: GO:0061545 ! tyramine secretion
created_by: dph
creation_date: 2013-06-21T15:57:12Z

[Term]
id: GO:0061533
name: norepinephrine secretion, neurotransmission
namespace: biological_process
def: "The regulated release of norepinephrine by a cell, in which the norepinephrine acts as a neurotransmitter." [GOC:dph]
synonym: "noradrenaline secretion, neurotransmission" EXACT [GOC:dph]
is_a: GO:0007269 ! neurotransmitter secretion
is_a: GO:0048243 ! norepinephrine secretion
created_by: dph
creation_date: 2013-06-21T16:05:08Z

[Term]
id: GO:0061534
name: gamma-aminobutyric acid secretion, neurotransmission
namespace: biological_process
def: "The regulated release of gamma-aminobutyric acid by a cell, in which the gamma-aminobutyric acid acts as a neurotransmitter." [GOC:dph]
is_a: GO:0007269 ! neurotransmitter secretion
is_a: GO:0014051 ! gamma-aminobutyric acid secretion
relationship: part_of GO:0051932 ! synaptic transmission, GABAergic
created_by: dph
creation_date: 2013-06-21T16:10:50Z

[Term]
id: GO:0061535
name: glutamate secretion, neurotransmission
namespace: biological_process
def: "The controlled release of glutamate by a cell, in which the glutamate acts as a neurotransmitter." [GOC:dph]
is_a: GO:0007269 ! neurotransmitter secretion
is_a: GO:0014047 ! glutamate secretion
relationship: part_of GO:0035249 ! synaptic transmission, glutamatergic
created_by: dph
creation_date: 2013-06-21T16:14:47Z

[Term]
id: GO:0061536
name: glycine secretion
namespace: biological_process
def: "The controlled release of glycine by a cell." [GOC:dph]
is_a: GO:0015816 ! glycine transport
is_a: GO:0032940 ! secretion by cell
is_a: GO:0046717 ! acid secretion
created_by: dph
creation_date: 2013-06-21T16:18:23Z

[Term]
id: GO:0061537
name: glycine secretion, neurotransmission
namespace: biological_process
def: "The controlled release of glycine by a cell, in which glycine acts as a neurotransmitter." [GOC:dph]
is_a: GO:0007269 ! neurotransmitter secretion
is_a: GO:0061536 ! glycine secretion
relationship: part_of GO:0060012 ! synaptic transmission, glycinergic
created_by: dph
creation_date: 2013-06-21T16:19:02Z

[Term]
id: GO:0061538
name: histamine secretion, neurotransmission
namespace: biological_process
def: "The controlled release of histamine by a cell, in which the histamine acts as a neurotransmitter." [GOC:dph]
is_a: GO:0001821 ! histamine secretion
is_a: GO:0007269 ! neurotransmitter secretion
created_by: dph
creation_date: 2013-06-21T16:21:21Z

[Term]
id: GO:0061539
name: octopamine secretion
namespace: biological_process
def: "The controlled release of octopamine by a cell." [GOC:dph]
is_a: GO:0015695 ! organic cation transport
is_a: GO:0015696 ! ammonium transport
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0032940 ! secretion by cell
created_by: dph
creation_date: 2013-06-21T16:24:02Z

[Term]
id: GO:0061540
name: octopamine secretion, neurotransmission
namespace: biological_process
def: "The controlled release of octopamine by a cell, in which the octopamine acts as a neurotransmitter." [GOC:dph]
is_a: GO:0007269 ! neurotransmitter secretion
is_a: GO:0061539 ! octopamine secretion
created_by: dph
creation_date: 2013-06-21T16:24:47Z

[Term]
id: GO:0061541
name: rhabdomere morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a rhabdomere are generated and organized. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [GOC:dph, PMID:22113834]
is_a: GO:0048812 ! neuron projection morphogenesis
relationship: part_of GO:0008594 ! photoreceptor cell morphogenesis
relationship: part_of GO:0042052 ! rhabdomere development
created_by: dph
creation_date: 2013-06-24T07:59:25Z

[Term]
id: GO:0061542
name: 3-demethylubiquinone-n 3-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinone-n = S-adenosyl-L-homocysteine + ubiquinone-n." [EC:2.1.1.64, GOC:dph]
synonym: "2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase" NARROW []
synonym: "5-demethylubiquinone-10 methyltransferase" NARROW []
synonym: "5-demethylubiquinone-9 methyltransferase" NARROW []
synonym: "OMHMB-methyltransferase" RELATED []
synonym: "S-adenosyl-L-methionine:2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone-O-methyltransferase" RELATED []
is_a: GO:0008171 ! O-methyltransferase activity
created_by: dph
creation_date: 2013-06-25T08:01:46Z

[Term]
id: GO:0061543
name: 3-demethylubiquinone-6 3-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinone-6 = S-adenosyl-L-homocysteine + ubiquinone-6." [GOC:dph]
is_a: GO:0061542 ! 3-demethylubiquinone-n 3-O-methyltransferase activity
created_by: dph
creation_date: 2013-06-25T08:05:14Z

[Term]
id: GO:0061544
name: peptide secretion, neurotransmission
namespace: biological_process
def: "The controlled release of a peptide from a cell in which the peptide acts as a neurotransmitter." [GOC:dph]
is_a: GO:0002790 ! peptide secretion
is_a: GO:0007269 ! neurotransmitter secretion
created_by: dph
creation_date: 2013-06-25T09:10:10Z

[Term]
id: GO:0061545
name: tyramine secretion
namespace: biological_process
def: "The regulated release of a tyramine by a cell." [GOC:dph]
is_a: GO:0015844 ! monoamine transport
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0061531 ! primary amine secretion
created_by: dph
creation_date: 2013-06-25T09:14:07Z

[Term]
id: GO:0061546
name: tyramine secretion, neurotransmission
namespace: biological_process
def: "The regulated release of a tyramine by a cell in which the tyramine acts as a neurotransmitter." [GOC:dph]
is_a: GO:0061532 ! primary amine secretion, neurotransmission
created_by: dph
creation_date: 2013-06-25T09:16:47Z

[Term]
id: GO:0061547
name: glycogen synthase activity, transferring glucose-1-phosphate
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UMP + (1,4)-alpha-D-glucosyl(n)-glucose-1-phosphate." [GOC:dph, PMID:21356517]
is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups
created_by: dph
creation_date: 2013-07-02T09:59:18Z

[Term]
id: GO:0061548
name: ganglion development
namespace: biological_process
def: "The process whose specific outcome is the progression of a ganglion over time, from its formation to the mature structure." [GOC:dph]
synonym: "ganglia development" RELATED [GOC:dph]
synonym: "gangliogenesis" NARROW [GOC:BHF, GOC:rl]
is_a: GO:0009888 ! tissue development
is_a: GO:0048513 ! animal organ development
relationship: part_of GO:0007399 ! nervous system development
created_by: dph
creation_date: 2013-07-10T08:36:12Z

[Term]
id: GO:0061549
name: sympathetic ganglion development
namespace: biological_process
def: "The process whose specific outcome is the progression of a sympathetic ganglion over time, from its formation to the mature structure." [GOC:BHF, GOC:rl]
synonym: "sympathetic ganglia development" RELATED [GOC:dph]
is_a: GO:0061548 ! ganglion development
relationship: part_of GO:0048485 ! sympathetic nervous system development
created_by: dph
creation_date: 2013-07-10T08:38:01Z

[Term]
id: GO:0061550
name: cranial ganglion development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cranial ganglion over time, from its formation to the mature structure." [GOC:dph]
synonym: "cranial ganglia development" RELATED [GOC:dph]
is_a: GO:0061548 ! ganglion development
relationship: part_of GO:0021545 ! cranial nerve development
created_by: dph
creation_date: 2013-07-10T08:40:14Z

[Term]
id: GO:0061551
name: trigeminal ganglion development
namespace: biological_process
def: "The process whose specific outcome is the progression of a trigeminal ganglion over time, from its formation to the mature structure." [GOC:dph]
synonym: "trigeminal ganglia development" RELATED [GOC:dph]
is_a: GO:0061550 ! cranial ganglion development
created_by: dph
creation_date: 2013-07-10T08:42:19Z

[Term]
id: GO:0061552
name: ganglion morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of ganglion are generated and organized." [GOC:dph]
synonym: "ganglia morphogenesis" RELATED [GOC:dph]
is_a: GO:0009887 ! organ morphogenesis
is_a: GO:0048729 ! tissue morphogenesis
relationship: part_of GO:0061548 ! ganglion development
created_by: dph
creation_date: 2013-07-10T08:44:57Z

[Term]
id: GO:0061553
name: ganglion maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for ganglion to attain its fully functional state." [GOC:dph]
synonym: "ganglia maturation" RELATED [GOC:dph]
is_a: GO:0048799 ! organ maturation
relationship: part_of GO:0061548 ! ganglion development
created_by: dph
creation_date: 2013-07-10T08:45:59Z

[Term]
id: GO:0061554
name: ganglion formation
namespace: biological_process
def: "The process that gives rise to ganglion. This process pertains to the initial formation of a structure from unspecified parts." [GOC:dph]
synonym: "ganglia formation" RELATED [GOC:dph]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0061552 ! ganglion morphogenesis
created_by: dph
creation_date: 2013-07-10T08:51:50Z

[Term]
id: GO:0061555
name: ganglion structural organization
namespace: biological_process
def: "The process that contributes to creating the structural organization of a ganglion. This process pertains to the physical shaping of a rudimentary structure." [GOC:dph]
synonym: "ganglia structural organization" RELATED [GOC:dph]
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0061552 ! ganglion morphogenesis
created_by: dph
creation_date: 2013-07-10T08:54:39Z

[Term]
id: GO:0061556
name: trigeminal ganglion morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of a trigeminal ganglion is generated and organized." [GOC:dph]
synonym: "trigeminal ganglia morphogenesis" RELATED [GOC:dph]
is_a: GO:0061559 ! cranial ganglion morphogenesis
relationship: part_of GO:0021636 ! trigeminal nerve morphogenesis
relationship: part_of GO:0061551 ! trigeminal ganglion development
created_by: dph
creation_date: 2013-07-10T08:57:12Z

[Term]
id: GO:0061557
name: trigeminal ganglion maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a trigeminal ganglion to attain its fully functional state." [GOC:dph]
synonym: "trigeminal ganglia maturation" RELATED [GOC:dph]
is_a: GO:0061558 ! cranial ganglion maturation
relationship: part_of GO:0021635 ! trigeminal nerve maturation
relationship: part_of GO:0061551 ! trigeminal ganglion development
created_by: dph
creation_date: 2013-07-10T08:58:24Z

[Term]
id: GO:0061558
name: cranial ganglion maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a cranial ganglion to attain its fully functional state." [GOC:dph]
synonym: "cranial ganglia maturation" RELATED [GOC:dph]
is_a: GO:0061553 ! ganglion maturation
relationship: part_of GO:0021605 ! cranial nerve maturation
relationship: part_of GO:0061550 ! cranial ganglion development
created_by: dph
creation_date: 2013-07-10T08:59:52Z

[Term]
id: GO:0061559
name: cranial ganglion morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of a cranial ganglion is generated and organized." [GOC:dph]
synonym: "cranial ganglia morphogenesis" RELATED [GOC:dph]
is_a: GO:0061552 ! ganglion morphogenesis
relationship: part_of GO:0021602 ! cranial nerve morphogenesis
relationship: part_of GO:0061550 ! cranial ganglion development
created_by: dph
creation_date: 2013-07-10T09:02:15Z

[Term]
id: GO:0061560
name: cranial ganglion formation
namespace: biological_process
def: "The process that gives rise to a cranial ganglion. This process pertains to the initial formation of a structure from unspecified parts." [GOC:dph]
synonym: "cranial ganglia formation" RELATED [GOC:dph]
is_a: GO:0061554 ! ganglion formation
relationship: part_of GO:0061559 ! cranial ganglion morphogenesis
created_by: dph
creation_date: 2013-07-10T09:07:27Z

[Term]
id: GO:0061561
name: trigeminal ganglion formation
namespace: biological_process
def: "The process that gives rise to the trigeminal ganglion. This process pertains to the initial formation of a structure from unspecified parts." [GOC:dph]
synonym: "trigeminal ganglia formation" RELATED [GOC:dph]
is_a: GO:0061560 ! cranial ganglion formation
relationship: part_of GO:0061556 ! trigeminal ganglion morphogenesis
created_by: dph
creation_date: 2013-07-10T09:08:13Z

[Term]
id: GO:0061562
name: cranial ganglion structural organization
namespace: biological_process
def: "The process that contributes to creating the structural organization of a cranial ganglion. This process pertains to the physical shaping of a rudimentary structure." [GOC:dph]
synonym: "cranial ganglia structural organization" RELATED [GOC:dph]
is_a: GO:0061555 ! ganglion structural organization
relationship: part_of GO:0021604 ! cranial nerve structural organization
relationship: part_of GO:0061559 ! cranial ganglion morphogenesis
created_by: dph
creation_date: 2013-07-10T09:10:52Z

[Term]
id: GO:0061563
name: trigeminal ganglion structural organization
namespace: biological_process
def: "The process that contributes to creating the structural organization of the trigeminal ganglion This process pertains to the physical shaping of a rudimentary structure." [GOC:dph]
synonym: "trigeminal ganglia organization" RELATED [GOC:dph]
is_a: GO:0061562 ! cranial ganglion structural organization
relationship: part_of GO:0021637 ! trigeminal nerve structural organization
relationship: part_of GO:0061556 ! trigeminal ganglion morphogenesis
created_by: dph
creation_date: 2013-07-10T09:12:11Z

[Term]
id: GO:0061564
name: axon development
namespace: biological_process
def: "The progression of an axon over time. Covers axonogenesis (de novo generation of an axon) and axon regeneration (regrowth), as well as processes pertaining to the progression of the axon over time (fasciculation and defasciculation)." [GOC:dph, GOC:pg, GOC:pr]
is_a: GO:0031175 ! neuron projection development
created_by: dph
creation_date: 2013-07-18T14:43:01Z

[Term]
id: GO:0061565
name: dAMP phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group into dAMP, deoxyadenosine monophosphate, to produce dADP. Addition of two phosphate groups produces dATP." [GOC:dph, PMID:23416111]
is_a: GO:0046940 ! nucleoside monophosphate phosphorylation
created_by: dph
creation_date: 2013-08-01T12:50:38Z

[Term]
id: GO:0061566
name: CMP phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group into CMP, cytidine monophosphate, to produce CDP. Addition of two phosphate groups produces CTP." [GOC:dph, PMID:23416111]
is_a: GO:0046940 ! nucleoside monophosphate phosphorylation
created_by: dph
creation_date: 2013-08-01T12:52:39Z

[Term]
id: GO:0061567
name: dCMP phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group into dCMP, deoxycytidine monophosphate, to produce dCDP. Addition of two phosphate groups produces dCTP." [GOC:dph, PMID:23416111]
is_a: GO:0046940 ! nucleoside monophosphate phosphorylation
created_by: dph
creation_date: 2013-08-01T12:54:21Z

[Term]
id: GO:0061568
name: GDP phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group into GDP, guanosine diphosphate, to produce GTP." [GOC:dph, PMID:23416111]
is_a: GO:0006165 ! nucleoside diphosphate phosphorylation
created_by: dph
creation_date: 2013-08-01T12:57:12Z

[Term]
id: GO:0061569
name: UDP phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group into UDP, uridine diphosphate, to produce UTP." [GOC:dph, PMID:23416111]
is_a: GO:0006165 ! nucleoside diphosphate phosphorylation
created_by: dph
creation_date: 2013-08-01T12:59:32Z

[Term]
id: GO:0061570
name: dCDP phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group into dCDP to produce a dCTP." [GOC:dph, PMID:23416111]
is_a: GO:0006165 ! nucleoside diphosphate phosphorylation
created_by: dph
creation_date: 2013-08-01T13:02:16Z

[Term]
id: GO:0061571
name: TDP phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group into TDP to produce a TTP." [GOC:dph, PMID:23416111]
is_a: GO:0006165 ! nucleoside diphosphate phosphorylation
created_by: dph
creation_date: 2013-08-01T13:03:34Z

[Term]
id: GO:0061572
name: actin filament bundle organization
namespace: biological_process
def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle." [GOC:dph]
synonym: "actin filament cable organization" RELATED [GOC:dph]
is_a: GO:0007015 ! actin filament organization
created_by: dph
creation_date: 2013-08-02T11:24:11Z

[Term]
id: GO:0061573
name: actin filament bundle retrograde transport
namespace: biological_process
def: "A process of actin filament bundle distribution that results in the arrangement of actin filament bundles from the periphery toward the interior of the cell." [GOC:dph]
synonym: "actin filament cable retrograde transport" RELATED [GOC:dph]
is_a: GO:0070650 ! actin filament bundle distribution
created_by: dph
creation_date: 2013-08-02T11:31:04Z

[Term]
id: GO:0061574
name: ASAP complex
namespace: cellular_component
def: "A protein complex involved in regulation of mRNA processing and apoptosis. It binds to RNA in a sequence-independent manner and is recruited to the EJC prior to or during the splicing process. In humans the core proteins are RNPS1, SAP18 and ACIN1." [GOC:dph, PMID:12665594, PMID:16314458, PMID:22388736]
is_a: GO:0043234 ! protein complex
created_by: dph
creation_date: 2013-10-08T13:09:16Z

[Term]
id: GO:0061575
name: cyclin-dependent protein serine/threonine kinase activator activity
namespace: molecular_function
def: "Binds to and increases the activity of a cyclin-dependent protein serine/threonine kinase." [GOC:dph, PMID:2569363, PMID:3322810]
is_a: GO:0016538 ! cyclin-dependent protein serine/threonine kinase regulator activity
is_a: GO:0043539 ! protein serine/threonine kinase activator activity
relationship: part_of GO:0045737 ! positive regulation of cyclin-dependent protein serine/threonine kinase activity
relationship: positively_regulates GO:0004693 ! cyclin-dependent protein serine/threonine kinase activity
created_by: dph
creation_date: 2013-10-08T13:50:35Z

[Term]
id: GO:0061576
name: acyl-CoA ceramide synthase complex
namespace: cellular_component
def: "A protein complex that catalyzes the reaction acyl-CoA + sphingosine = CoA + N-acylsphingosine. In S. cerevisiae it contains three subunits: lag1, lac1 and lip1." [GOC:dph, PMID:15692566]
is_a: GO:0043234 ! protein complex
created_by: dph
creation_date: 2013-10-24T14:42:06Z

[Term]
id: GO:0061577
name: calcium ion transmembrane transport via high voltage-gated calcium channel
namespace: biological_process
def: "A process in which a calcium ion is transported from one side of a membrane to the other by means of a high voltage-gated calcium channel." [GOC:dph]
synonym: "generation of L-type calcium current" RELATED []
is_a: GO:0070588 ! calcium ion transmembrane transport
relationship: has_part GO:0008331 ! high voltage-gated calcium channel activity
created_by: dph
creation_date: 2013-11-15T16:20:27Z

[Term]
id: GO:0061578
name: Lys63-specific deubiquitinase activity
namespace: molecular_function
def: "Hydrolysis of Lys63-Linked ubiquitin unit(s) from a ubiquitinated protein." [GOC:dph, GOC:pg, PMID:18313383]
is_a: GO:0101005 ! ubiquitinyl hydrolase activity
relationship: part_of GO:0070536 ! protein K63-linked deubiquitination
created_by: dph
creation_date: 2013-11-15T19:13:12Z

[Term]
id: GO:0061579
name: N-acyl homoserine lactone synthase activity
namespace: molecular_function
def: "Catalyzing the reaction: acyl-[acyl-carrier-protein] + S-adenosyl-L-methionine -> [acyl-carrier- protein] + S-methyl-5'-thioadenosine + N-acyl-L-homoserine lactone." [GOC:dph]
synonym: "autoinducer-1 synthase" RELATED [GOC:dph]
xref: EC:2.3.1.184
is_a: GO:0016410 ! N-acyltransferase activity
created_by: dph
creation_date: 2013-11-15T19:48:23Z

[Term]
id: GO:0061580
name: colon epithelial cell migration
namespace: biological_process
def: "The orderly movement of a colonic epithelial cell from one site to another, often during the development of a multicellular organism." [GOC:dph]
is_a: GO:0061582 ! intestinal epithelial cell migration
created_by: dph
creation_date: 2013-12-23T07:26:54Z

[Term]
id: GO:0061581
name: corneal epithelial cell migration
namespace: biological_process
def: "The orderly movement of a corneal  epithelial cell from one site to another, often during the development of a multicellular organism." [GOC:dph]
is_a: GO:0010631 ! epithelial cell migration
created_by: dph
creation_date: 2013-12-23T07:28:29Z

[Term]
id: GO:0061582
name: intestinal epithelial cell migration
namespace: biological_process
def: "The orderly movement of an intestinal epithelial cell from one site to another, often during the development of a multicellular organism." [GOC:dph]
is_a: GO:0010631 ! epithelial cell migration
created_by: dph
creation_date: 2013-12-23T07:30:55Z

[Term]
id: GO:0061583
name: colon epithelial cell chemotaxis
namespace: biological_process
def: "The directed movement of a colon epithelial cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [GOC:dph]
is_a: GO:0060326 ! cell chemotaxis
is_a: GO:0061580 ! colon epithelial cell migration
created_by: dph
creation_date: 2013-12-23T07:46:57Z

[Term]
id: GO:0061584
name: hypocretin secretion
namespace: biological_process
def: "The controlled release of hypocretin from a cell or a tissue." [GOC:dph]
synonym: "orexin secretion" EXACT [GOC:dph]
is_a: GO:0002790 ! peptide secretion
created_by: dph
creation_date: 2013-12-26T10:07:38Z

[Term]
id: GO:0061585
name: hypocretin secretion, neurotransmission
namespace: biological_process
def: "The controlled release of a peptide from a cell or a tissue in which the peptide acts as a neurotransmitter." [GOC:dph]
synonym: "orexin secretion, neurotransmission" EXACT [GOC:dph]
is_a: GO:0061544 ! peptide secretion, neurotransmission
is_a: GO:0061584 ! hypocretin secretion
created_by: dph
creation_date: 2013-12-26T10:09:37Z

[Term]
id: GO:0061586
name: positive regulation of transcription by transcription factor localization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves the localization of a transcription factor." [GOC:dph]
is_a: GO:0034613 ! cellular protein localization
is_a: GO:0045893 ! positive regulation of transcription, DNA-templated
created_by: dph
creation_date: 2014-01-31T08:43:43Z

[Term]
id: GO:0061587
name: transfer RNA gene-mediated silencing
namespace: biological_process
def: "The chromatin silencing that results in the inhibition of RNA polymerase II-transcribed genes located in the vicinity of tRNA genes." [GOC:dph, PMID:23707796]
synonym: "tgm silencing" EXACT [PMID:23707796]
synonym: "transfer RNA gene-mediated chromatin silencing" EXACT [GOC:dph]
synonym: "transfer RNA gene-mediated gene silencing" EXACT [GOC:dph]
synonym: "tRNA gene-mediated chromatin silencing" EXACT [GOC:dph]
synonym: "tRNA gene-mediated gene silencing" EXACT [GOC:dph]
is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
is_a: GO:0006342 ! chromatin silencing
created_by: dph
creation_date: 2014-02-05T09:03:59Z

[Term]
id: GO:0061588
name: calcium activated phospholipid scrambling
namespace: biological_process
def: "The movement of a population of phospholipid molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet as a result of a calcium stimulus." [GOC:krc, PMID:23532839]
is_a: GO:0017121 ! phospholipid scrambling
created_by: dph
creation_date: 2014-02-05T15:14:34Z

[Term]
id: GO:0061589
name: calcium activated phosphatidylserine scrambling
namespace: biological_process
def: "The movement of a population of phosphatidylserine molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet as a result of a calcium stimulus." [GOC:krc, PMID:23532839]
is_a: GO:0061588 ! calcium activated phospholipid scrambling
created_by: dph
creation_date: 2014-02-05T15:17:21Z

[Term]
id: GO:0061590
name: calcium activated phosphatidylcholine scrambling
namespace: biological_process
def: "The movement of a population of phosphatidylcholine molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet as a result of a calcium stimulus." [GOC:krc, PMID:23532839]
is_a: GO:0061588 ! calcium activated phospholipid scrambling
created_by: dph
creation_date: 2014-02-05T15:23:03Z

[Term]
id: GO:0061591
name: calcium activated galactosylceramide scrambling
namespace: biological_process
def: "The movement of a population of galactosylceramide molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet as a result of a calcium stimulus." [GOC:krc, PMID:23532839]
is_a: GO:0061588 ! calcium activated phospholipid scrambling
created_by: dph
creation_date: 2014-02-05T15:25:52Z

[Term]
id: GO:0061592
name: phosphatidylserine exposure on osteoblast involved in bone mineralization
namespace: biological_process
def: "A phospholipid scrambling process that results in the appearance of phosphatidylserine on the surface of osteoblasts, and contributes to bone mineralization." [GOC:krc, PMID:22936354]
is_a: GO:0017121 ! phospholipid scrambling
relationship: part_of GO:0030282 ! bone mineralization
created_by: dph
creation_date: 2014-02-05T15:27:39Z

[Term]
id: GO:0061593
name: sulfoquinovose isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction sulfoquinovose = 6-deoxy-6-sulfofructose." [GOC:dph, PMID:24463506]
is_a: GO:0016853 ! isomerase activity
created_by: dph
creation_date: 2014-02-10T09:56:04Z

[Term]
id: GO:0061594
name: 6-deoxy-6-sulfofructose kinase activity
namespace: molecular_function
def: "Catalysis of the reaction 6-deoxy-6-sulfofructose + ATP = 6-deoxy-6-sulfofructose-1-phosphate + ADP." [PMID:24463506]
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
created_by: dph
creation_date: 2014-02-10T09:59:26Z

[Term]
id: GO:0061595
name: 6-deoxy-6-sulfofructose-1-phosphate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction 6-deoxy-6-sulfofructose-1-phosphate = 3-sulfolactaldehyde + dihydroxyacetone phosphate." [PMID:24463506]
is_a: GO:0016832 ! aldehyde-lyase activity
created_by: dph
creation_date: 2014-02-10T10:05:27Z

[Term]
id: GO:0061596
name: 3-sulfolactaldehyde reductase activity
namespace: molecular_function
def: "Catalysis of the reaction 2,3-dihydroxypropane-1-sulfonate + NAD+ = 3-sulfolactaldehyde + NADH + H+." [GOC:dph, PMID:24463506]
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
created_by: dph
creation_date: 2014-02-10T10:09:43Z

[Term]
id: GO:0061597
name: cyclic pyranopterin monophosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction GTP = cyclic pyranopterin phosphate + diphosphate." [EC:4.1.99.18, GOC:dph, PMID:18154309]
xref: EC:4.1.99.18
xref: RHEA:26380
is_a: GO:0016830 ! carbon-carbon lyase activity
created_by: dph
creation_date: 2014-02-10T13:54:19Z

[Term]
id: GO:0061598
name: molybdopterin adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction ATP + molybdopterin = diphosphate + adenylyl-molybdopterin." [EC:2.7.7.75, GOC:dph]
xref: EC:2.7.7.75
xref: RHEA:31334
is_a: GO:0070566 ! adenylyltransferase activity
created_by: dph
creation_date: 2014-02-10T14:14:06Z

[Term]
id: GO:0061599
name: molybdopterin molybdotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction adenylyl-molybdopterin + molybdate = molybdenum cofactor + AMP." [EC:2.10.1.1, GOC:dph]
xref: EC:2.10.1.1
is_a: GO:0016740 ! transferase activity
created_by: dph
creation_date: 2014-02-10T14:30:31Z

[Term]
id: GO:0061602
name: molybdenum cofactor cytidylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction CTP + molybdenum cofactor = diphosphate + cytidylyl molybdenum cofactor." [EC:2.7.7.76, GOC:dph]
xref: EC:2.7.7.76
is_a: GO:0070567 ! cytidylyltransferase activity
created_by: dph
creation_date: 2014-02-10T14:46:38Z

[Term]
id: GO:0061603
name: molybdenum cofactor guanylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction GTP + molybdenum cofactor = diphosphate + guanylyl molybdenum cofactor." [EC:2.7.7.77, GOC:dph]
xref: EC:2.7.7.77
is_a: GO:0070568 ! guanylyltransferase activity
created_by: dph
creation_date: 2014-02-10T14:54:36Z

[Term]
id: GO:0061604
name: molybdopterin-synthase sulfurtransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: [Molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP + [cysteine desulfurase]-S-sulfanyl-L-cysteine <=> AMP [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH(2)-C(O)SH + cysteine desulfurase." [EC:2.8.1.11, GOC:dph, PMID:18154309, PMID:22370186]
xref: EC:2.8.1.11
is_a: GO:0016783 ! sulfurtransferase activity
created_by: dph
creation_date: 2014-02-11T11:56:16Z

[Term]
id: GO:0061605
name: molybdopterin-synthase adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly = diphosphate [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP." [EC:2.7.7.80, GOC:dph, PMID:18154309, PMID:22370186]
xref: EC:2.7.7.80
is_a: GO:0070566 ! adenylyltransferase activity
created_by: dph
creation_date: 2014-02-11T12:01:32Z

[Term]
id: GO:0061606
name: N-terminal protein amino acid propionylation
namespace: biological_process
def: "The propionylation of the N-terminal amino acid of proteins." [GOC:dph, PMID:17267393, PMID:23043182]
is_a: GO:0043687 ! post-translational protein modification
created_by: dph
creation_date: 2014-02-11T14:13:05Z

[Term]
id: GO:0061607
name: peptide alpha-N-propionyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: propionyl-CoA + peptide = CoA + N-alpha-propionylpeptide. This reaction is the propionylation of the N-terminal amino acid residue of a peptide or protein." [GOC:dph, PMID:23043182]
synonym: "N-terminal propionyltransferase activity" EXACT [PMID:23043182]
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups
relationship: part_of GO:0061606 ! N-terminal protein amino acid propionylation
created_by: dph
creation_date: 2014-02-11T14:24:35Z

[Term]
id: GO:0061608
name: nuclear import signal receptor activity
namespace: molecular_function
def: "Combining with a nuclear import signal (NIS) to mediate transport of the NIS-containing protein through the nuclear pore to the nucleus." [GOC:dph, GOC:vw]
is_a: GO:0005487 ! nucleocytoplasmic transporter activity
is_a: GO:0008565 ! protein transporter activity
created_by: dph
creation_date: 2014-03-03T07:58:18Z

[Term]
id: GO:0061609
name: fructose-1-phosphate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-fructose-1-phosphate = dihydroxyacetone phosphate + D-glyceraldehyde." [GOC:dph, GOC:glycolysis, ISBN:0201090910, RHEA:30854]
xref: RHEA:30854
is_a: GO:0016832 ! aldehyde-lyase activity
created_by: dph
creation_date: 2014-03-28T08:54:24Z

[Term]
id: GO:0061610
name: glycerol to glycerone phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways in which glycerol, 1,2,3-propanetriol, is converted to glycerone phosphate." [GOC:dph, ISBN:0201090910]
synonym: "glycerol metabolism to DHAP" EXACT [GOC:dph]
synonym: "glycerol metabolism to dihydroxyacetone phosphate" EXACT [GOC:dph]
synonym: "glycerol metabolism to glycerone phosphate" EXACT [GOC:dph]
synonym: "glycerol to DHAP metabolic process" EXACT [GOC:dph]
synonym: "glycerol to dihydroxyacetone phosphate metabolic process" EXACT [GOC:dph]
is_a: GO:0006071 ! glycerol metabolic process
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:0042180 ! cellular ketone metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process
relationship: has_part GO:0004367 ! glycerol-3-phosphate dehydrogenase [NAD+] activity
created_by: dph
creation_date: 2014-04-03T13:26:21Z

[Term]
id: GO:0061611
name: mannose to fructose-6-phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways in which mannose, the aldohexose manno-hexose, is converted to fructose-6-phosphate." [GOC:dph, ISBN:0201090910, ISBN:0879010479]
synonym: "mannose metabolism to fructose-6-phosphate" EXACT [GOC:dph]
is_a: GO:0006002 ! fructose 6-phosphate metabolic process
is_a: GO:0006013 ! mannose metabolic process
is_a: GO:0044763 ! single-organism cellular process
created_by: dph
creation_date: 2014-04-03T13:38:50Z

[Term]
id: GO:0061612
name: galactose to glucose-1-phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways in which galactose, the aldohexose galacto-hexose, is converted to glucose-1-phosphate." [GOC:dph, ISBN:0201090910, ISBN:0879010479]
is_a: GO:0006012 ! galactose metabolic process
is_a: GO:0044763 ! single-organism cellular process
relationship: has_part GO:0003978 ! UDP-glucose 4-epimerase activity
created_by: dph
creation_date: 2014-04-04T08:18:49Z

[Term]
id: GO:0061613
name: glycolytic process from glycerol
namespace: biological_process
def: "The glycolytic process in which glycerol is catabolized to pyruvate generating ATP and NADH." [GOC:dph, ISBN:0201090910]
is_a: GO:0006096 ! glycolytic process
is_a: GO:0019563 ! glycerol catabolic process
is_a: GO:0042180 ! cellular ketone metabolic process
relationship: has_part GO:0004807 ! triose-phosphate isomerase activity
created_by: dph
creation_date: 2014-04-04T08:26:57Z

[Term]
id: GO:0061614
name: pri-miRNA transcription from RNA polymerase II promoter
namespace: biological_process
def: "The cellular synthesis of primary microRNA (pri-miRNA) transcripts from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. pri-miRNA transcripts are subsequently processed to produce the ~22nt miRNAs that function in gene regulation." [GOC:dph, GOC:kmv, PMID:18778799]
is_a: GO:0006366 ! transcription from RNA polymerase II promoter
created_by: dph
creation_date: 2014-04-08T08:42:54Z

[Term]
id: GO:0061615
name: glycolytic process through fructose-6-phosphate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a monosaccharide into pyruvate, occurring through a fructose-6-phosphate intermediate, with the concomitant production of ATP and NADH." [GOC:dph, ISBN:0201090910, ISBN:0879010479]
synonym: "glycolysis through fructose-6-phosphate" EXACT [GOC:dph]
xref: MetaCyc:PWY-5484
is_a: GO:0006096 ! glycolytic process
intersection_of: GO:0006096 ! glycolytic process
intersection_of: has_part GO:0003872 ! 6-phosphofructokinase activity
intersection_of: has_part GO:0004332 ! fructose-bisphosphate aldolase activity
intersection_of: has_part GO:0004807 ! triose-phosphate isomerase activity
relationship: has_part GO:0003872 ! 6-phosphofructokinase activity
relationship: has_part GO:0004332 ! fructose-bisphosphate aldolase activity
relationship: has_part GO:0004807 ! triose-phosphate isomerase activity
created_by: dph
creation_date: 2014-04-08T10:08:49Z

[Term]
id: GO:0061616
name: glycolytic process from fructose through fructose-6-phosphate
namespace: biological_process
def: "The glycolytic process through fructose-6-phosphate in which fructose is catabolized into pyruvate." [GOC:dph, ISBN:0201090910, ISBN:0879010479]
synonym: "glycolysis from fructose through fructose-6-phosphate" EXACT [GOC:dph]
xref: MetaCyc:PWY-5484
is_a: GO:0006001 ! fructose catabolic process
is_a: GO:0061615 ! glycolytic process through fructose-6-phosphate
created_by: dph
creation_date: 2014-04-08T10:20:37Z

[Term]
id: GO:0061617
name: MICOS complex
namespace: cellular_component
def: "Mitochondrial inner membrane complex involved in maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. In Saccharomyces cerevisiae the complex has six subunits: MIC10, MIC12, MIC19, MIC26, MIC27, and MIC60." [GOC:dph, PMID:21944719, PMID:21987634, PMID:22009199, PMID:24687277]
synonym: "Fcj1 complex" EXACT [GOC:dph]
synonym: "MIB complex" EXACT [GOC:dph]
synonym: "MINOS complex" EXACT [GOC:dph]
synonym: "mitochondrial contact site and cristae organizing system" EXACT [GOC:dph]
synonym: "Mitofilin complex" EXACT [GOC:dph]
synonym: "MitOS complex" EXACT [GOC:dph]
is_a: GO:0098800 ! inner mitochondrial membrane protein complex
relationship: part_of GO:0031305 ! integral component of mitochondrial inner membrane
created_by: dph
creation_date: 2014-04-14T07:18:13Z

[Term]
id: GO:0061618
name: sublamina densa
namespace: cellular_component
def: "The part of the basement membrane that lies beneath the lamina densa, containing anchoring fibrils, anchoring plaques, collagen fibers, and elastic fibers." [GOC:BHF, PMID:15623520]
is_a: GO:0044420 ! extracellular matrix component
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005604 ! basement membrane
created_by: dph
creation_date: 2014-04-14T08:43:13Z

[Term]
id: GO:0061619
name: glycolytic process from mannose through fructose-6-phosphate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of mannose into pyruvate, occurring through a fructose-6-phosphate intermediate, with the concomitant production of ATP and NADH." [GOC:dph, ISBN:0201090910, ISBN:0879010479]
is_a: GO:0006002 ! fructose 6-phosphate metabolic process
is_a: GO:0019309 ! mannose catabolic process
is_a: GO:0061615 ! glycolytic process through fructose-6-phosphate
created_by: dph
creation_date: 2014-04-14T09:13:13Z

[Term]
id: GO:0061620
name: glycolytic process through glucose-6-phosphate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, occurring through a glucose-6-phosphate intermediate, with the concomitant production of a small amount of ATP." [GOC:dph, ISBN:0201090910, ISBN:0879010479]
xref: MetaCyc:GLYCOLYSIS
is_a: GO:0061615 ! glycolytic process through fructose-6-phosphate
intersection_of: GO:0061615 ! glycolytic process through fructose-6-phosphate
intersection_of: has_part GO:0004347 ! glucose-6-phosphate isomerase activity
relationship: has_part GO:0004347 ! glucose-6-phosphate isomerase activity
created_by: dph
creation_date: 2014-04-14T09:17:48Z

[Term]
id: GO:0061621
name: canonical glycolysis
namespace: biological_process
def: "The glycolytic process that begins with the conversion of glucose to glucose-6-phosphate by glucokinase activity. Glycolytic processes are the  chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP." [GOC:dph, ISBN:0201090910, ISBN:0879010479]
xref: MetaCyc:ANAGLYCOLYSIS-PWY
xref: MetaCyc:PWY66-400
xref: Reactome:R-HSA-70171 "Glycolysis, Homo sapiens"
xref: Wikipedia:Glycolysis
is_a: GO:0006735 ! NADH regeneration
is_a: GO:0061620 ! glycolytic process through glucose-6-phosphate
is_a: GO:0061718 ! glucose catabolic process to pyruvate
relationship: has_part GO:0004365 ! glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
created_by: dph
creation_date: 2014-04-14T09:21:54Z

[Term]
id: GO:0061622
name: glycolytic process through glucose-1-phosphate
namespace: biological_process
def: "The chemical reactions and pathways through a glucose-1-phosphate intermediate that result in the catabolism of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP." [GOC:dph, ISBN:0201090910]
is_a: GO:0061620 ! glycolytic process through glucose-6-phosphate
intersection_of: GO:0061620 ! glycolytic process through glucose-6-phosphate
intersection_of: has_part GO:0004614 ! phosphoglucomutase activity
relationship: has_part GO:0004614 ! phosphoglucomutase activity
created_by: dph
creation_date: 2014-04-28T08:08:01Z

[Term]
id: GO:0061623
name: glycolytic process from galactose
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of galactose into pyruvate, with the concomitant production of a small amount of ATP." [GOC:dph, ISBN:0201090910]
is_a: GO:0019388 ! galactose catabolic process
is_a: GO:0061622 ! glycolytic process through glucose-1-phosphate
created_by: dph
creation_date: 2014-04-28T08:13:38Z

[Term]
id: GO:0061624
name: fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of fructose that results in the formation of dihydroxyacetone phosphate and glyceraldehyde-3-phosphate." [GOC:dph, ISBN:0201090910]
is_a: GO:0006001 ! fructose catabolic process
is_a: GO:0019682 ! glyceraldehyde-3-phosphate metabolic process
relationship: has_part GO:0050354 ! triokinase activity
relationship: has_part GO:0061609 ! fructose-1-phosphate aldolase activity
created_by: dph
creation_date: 2014-04-29T12:58:28Z

[Term]
id: GO:0061625
name: glycolytic process through fructose-1-phosphate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of fructose into pyruvate through a fructose-1-phosphate intermediate, with the concomitant production of ATP and NADH." [GOC:dph, ISBN:0201090910]
is_a: GO:0006001 ! fructose catabolic process
is_a: GO:0006096 ! glycolytic process
is_a: GO:0019682 ! glyceraldehyde-3-phosphate metabolic process
relationship: has_part GO:0004807 ! triose-phosphate isomerase activity
created_by: dph
creation_date: 2014-04-29T13:04:10Z

[Term]
id: GO:0061626
name: pharyngeal arch artery morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a pharyngeal arch artery is generated and organized. The pharyngeal arch arteries are a series of six paired embryological vascular structures, the development of which give rise to several major arteries, such as the stapedial artery, the middle meningeal artery, the internal carotid artery and the pulmonary artery." [GOC:BHF, GOC:dph, PMID:20122914]
synonym: "aortic arch artery morphogenesis" BROAD [GOC:dph]
is_a: GO:0048844 ! artery morphogenesis
relationship: part_of GO:0060037 ! pharyngeal system development
created_by: dph
creation_date: 2014-05-09T15:34:06Z

[Term]
id: GO:0061627
name: S-methylmethionine-homocysteine S-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H+." [EC:2.1.1.10, GOC:BHF, GOC:dph]
synonym: "homocysteine methyltransferase activity" RELATED [EC:2.1.1.10]
synonym: "homocysteine transmethylase activity" RELATED [EC:2.1.1.10]
synonym: "methylmethionine:homocysteine methyltransferase activity" EXACT [EC:2.1.1.10]
synonym: "S-methylmethionine homocysteine transmethylase activity" EXACT [EC:2.1.1.10]
xref: RHEA:26337
is_a: GO:0008172 ! S-methyltransferase activity
created_by: dph
creation_date: 2014-05-14T14:32:02Z

[Term]
id: GO:0061628
name: H3K27me3 modified histone binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a histone H3 in which the lysine residue at position 27 has been modified by trimethylation." [GOC:dph, PMID:23948251]
synonym: "H3-K27me3 modified histone binding" EXACT [GOC:dph]
is_a: GO:0035064 ! methylated histone binding
created_by: dph
creation_date: 2014-05-14T15:36:53Z

[Term]
id: GO:0061629
name: RNA polymerase II sequence-specific DNA binding transcription factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription." [GOC:dph, GOC:vw]
is_a: GO:0001085 ! RNA polymerase II transcription factor binding
created_by: dph
creation_date: 2014-05-15T09:12:24Z

[Term]
id: GO:0061630
name: ubiquitin protein ligase activity
namespace: molecular_function
def: "Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S --> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate. Note that this may include the extension of ubiquitin chains." [GOC:BioGRID, GOC:dph]
synonym: "E3" RELATED [GOC:dph]
synonym: "protein ubiquitination activity" EXACT [GOC:dph]
synonym: "ubiquitin ligase activity" EXACT [GOC:dph]
is_a: GO:0004842 ! ubiquitin-protein transferase activity
is_a: GO:0061659 ! ubiquitin-like protein ligase activity
created_by: dph
creation_date: 2014-05-18T09:11:21Z

[Term]
id: GO:0061631
name: ubiquitin conjugating enzyme activity
namespace: molecular_function
def: "Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y -> Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [GOC:BioGRID, GOC:dph]
synonym: "E2" RELATED [GOC:dph]
synonym: "HECT E3" RELATED [GOC:dph]
is_a: GO:0004842 ! ubiquitin-protein transferase activity
is_a: GO:0061650 ! ubiquitin-like protein conjugating enzyme activity
created_by: dph
creation_date: 2014-05-18T09:25:19Z

[Term]
id: GO:0061632
name: RNA lariat debranching enzyme activator activity
namespace: molecular_function
def: "Increases the activity of an enzyme that catalyzes the hydrolysis of branched RNA structures that contain vicinal 2'-5'- and 3'-5'-phosphodiester bonds at a branch point nucleotide." [GOC:dph, PMID:24919400]
is_a: GO:0008047 ! enzyme activator activity
relationship: positively_regulates GO:0008419 ! RNA lariat debranching enzyme activity
created_by: dph
creation_date: 2014-06-17T10:07:31Z

[Term]
id: GO:0061633
name: transport-coupled glycolytic process through glucose-6-phosphate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glucose into pyruvate, in which the glucose is converted to glucose-6-phosphate intermediate coupled to transmembrane transport." [GOC:dph]
is_a: GO:0061620 ! glycolytic process through glucose-6-phosphate
is_a: GO:0061718 ! glucose catabolic process to pyruvate
created_by: dph
creation_date: 2014-06-19T09:12:37Z

[Term]
id: GO:0061634
name: alpha-D-xyloside xylohydrolase
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal, non-reducing alpha-D-xylose residues with release of alpha-D-xylose." [EC:3.2.1.177]
synonym: "alpha-xylosidase" EXACT [EC:3.2.1.177]
xref: EC:3.2.1.177
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds
created_by: dph
creation_date: 2014-07-28T08:12:39Z

[Term]
id: GO:0061635
name: regulation of protein complex stability
namespace: biological_process
def: "Any process that affects the structure and integrity of a protein complex by altering the likelihood of its assembly or disassembly." [GOC:dph]
is_a: GO:0065008 ! regulation of biological quality
created_by: dph
creation_date: 2014-08-13T14:40:21Z

[Term]
id: GO:0061636
name: mitotic anaphase-promoting complex activator activity
namespace: molecular_function
def: "Increases the activity of a mitotic anaphase promoting complex, an ubiquitin-protein transferase activity that regulates the mitotic metaphase/anaphase transition." [GOC:dph]
is_a: GO:0097027 ! ubiquitin-protein transferase activator activity
relationship: part_of GO:0007092 ! activation of APC-Cdc20 complex activity
created_by: dph
creation_date: 2014-08-18T14:23:50Z

[Term]
id: GO:0061637
name: mitotic anaphase-promoting complex inhibitor activity
namespace: molecular_function
def: "Prevents the activation of a mitotic anaphase promoting complex, a ubiquitin-protein transferase activity that regulates mitotic cell cycle transitions." [GOC:dph, GOC:vw]
is_a: GO:0055105 ! ubiquitin-protein transferase inhibitor activity
relationship: negatively_regulates GO:0090302 ! APC-Cdc20 complex activity
created_by: dph
creation_date: 2014-08-18T14:28:21Z

[Term]
id: GO:0061638
name: CENP-A containing chromatin
namespace: cellular_component
def: "The specialized chromatin located the centromeric core region or the entire centromeric region in organisms with point centromeres, which is enriched for CENP-A-containing nucleosomes. This chromatin forms a 3-dimensional structure which provides a platform for kinetochore assembly and microtubule attachment." [GOC:vw, PMID:20206496, PMID:22729156]
synonym: "centromeric core domain chromatin" RELATED [GOC:vw]
synonym: "centromeric core region chromatin" EXACT [GOC:vw]
is_a: GO:0000785 ! chromatin
relationship: part_of GO:0034506 ! chromosome, centromeric core domain
created_by: dph
creation_date: 2014-08-20T14:06:35Z

[Term]
id: GO:0061639
name: Cdv-dependent cytokinesis
namespace: biological_process
def: "A cytokinesis that involves a set of conserved proteins including the Cdv proteins, and results in the formation of two similarly sized and shaped cells." [GOC:dph, PMID:18987308]
is_a: GO:0000910 ! cytokinesis
created_by: dph
creation_date: 2014-08-21T14:55:04Z

[Term]
id: GO:0061640
name: cytoskeleton-dependent cytokinesis
namespace: biological_process
def: "A cytokinesis that involves the function of a set of proteins that are part of the microfilament or microtubule cytoskeleton." [GOC:dph]
is_a: GO:0000910 ! cytokinesis
created_by: dph
creation_date: 2014-08-22T14:21:35Z

[Term]
id: GO:0061641
name: CENP-A containing chromatin organization
namespace: biological_process
def: "Any process that results in the specification, formation or maintenance of the physical structure of CENP-A containing chromatin." [GOC:dph]
synonym: "centromeric chromatin organization" RELATED [GOC:dph]
is_a: GO:0006325 ! chromatin organization
created_by: dph
creation_date: 2014-08-27T12:26:14Z

[Term]
id: GO:0061642
name: chemoattraction of axon
namespace: biological_process
def: "The process in which a neuron growth cone is directed to a specific target site in response to an attractive chemical signal." [GOC:dph, GOC:krc]
is_a: GO:0050918 ! positive chemotaxis
intersection_of: GO:0050918 ! positive chemotaxis
intersection_of: part_of GO:0007411 ! axon guidance
relationship: part_of GO:0007411 ! axon guidance
relationship: part_of GO:0070887 ! cellular response to chemical stimulus
created_by: dph
creation_date: 2014-08-29T08:21:24Z

[Term]
id: GO:0061643
name: chemorepulsion of axon
namespace: biological_process
def: "The process in which a neuron growth cone is directed to a specific target site in response to a repulsive chemical cue." [GOC:dph, GOC:krc]
is_a: GO:0050919 ! negative chemotaxis
intersection_of: GO:0050919 ! negative chemotaxis
intersection_of: part_of GO:0007411 ! axon guidance
relationship: part_of GO:0007411 ! axon guidance
relationship: part_of GO:0070887 ! cellular response to chemical stimulus
created_by: dph
creation_date: 2014-08-29T08:35:40Z

[Term]
id: GO:0061644
name: protein localization to CENP-A containing chromatin
namespace: biological_process
def: "Any process in which a protein is transported to, or maintained at, CENP-A containing chromatin." [GOC:dph, GOC:vw]
is_a: GO:0071168 ! protein localization to chromatin
is_a: GO:0071459 ! protein localization to chromosome, centromeric region
created_by: dph
creation_date: 2014-08-29T12:17:05Z

[Term]
id: GO:0061645
name: endocytic patch
namespace: cellular_component
def: "The part of the cell cortex consisting of  an aggregation of proteins that will give rise to an endocytic vesicle." [GOC:dph, PMID:22949647]
is_a: GO:0044448 ! cell cortex part
created_by: dph
creation_date: 2014-09-02T09:23:38Z

[Term]
id: GO:0061646
name: positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glutamate secretion in response to membrane depolarization, where glutamate acts as a neurotransmitter." [GOC:pad, GOC:PARL]
is_a: GO:0051716 ! cellular response to stimulus
is_a: GO:1903296 ! positive regulation of glutamate secretion, neurotransmission
created_by: dph
creation_date: 2014-10-02T14:18:49Z

[Term]
id: GO:0061647
name: histone H3-K9 modification
namespace: biological_process
def: "The modification of histone H3 at a lysine in position 9 of the histone." [GOC:vw]
is_a: GO:0016570 ! histone modification
created_by: dph
creation_date: 2014-10-02T15:07:42Z

[Term]
id: GO:0061648
name: tooth replacement
namespace: biological_process
def: "The process whose specific outcome is the replacement of an existing tooth with another tooth." [GOC:dph, PMID:15170864]
is_a: GO:0042476 ! odontogenesis
created_by: dph
creation_date: 2014-10-02T15:26:53Z

[Term]
id: GO:0061649
name: ubiquitinated histone binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a histone protein in which a residue has been modified by ubiquitination. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes." [GOC:dph, PMID:24526689]
is_a: GO:0042393 ! histone binding
created_by: dph
creation_date: 2014-11-04T10:21:04Z

[Term]
id: GO:0061650
name: ubiquitin-like protein conjugating enzyme activity
namespace: molecular_function
def: "Isoenergetic transfer of a ubiquitin-like protein (ULP) from one protein to another via the reaction X-SCP + Y -> Y-SCP + X, where both the X-SCP and Y-SCP linkages are thioester bonds between the C-terminal amino acid of SCP and a sulfhydryl side group of a cysteine residue." [GOC:dph]
synonym: "E2" RELATED []
synonym: "small conjugating protein conjugating enzyme activity" EXACT [GOC:dph]
is_a: GO:0019787 ! ubiquitin-like protein transferase activity
created_by: dph
creation_date: 2014-11-06T13:15:27Z

[Term]
id: GO:0061651
name: Atg12 conjugating enzyme activity
namespace: molecular_function
def: "Isoenergetic transfer of Atg12 from one protein to another via the reaction X-Atg12 + Y -> Y-Atg12 + X, where both the X-Atg12 and Y-Atg12 linkages are thioester bonds between the C-terminal amino acid of Atg12 and a sulfhydryl side group of a cysteine residue." [GOC:dph]
synonym: "E2" RELATED [GOC:dph]
is_a: GO:0019777 ! Atg12 transferase activity
is_a: GO:0061650 ! ubiquitin-like protein conjugating enzyme activity
created_by: dph
creation_date: 2014-11-06T13:17:36Z

[Term]
id: GO:0061652
name: FAT10 conjugating enzyme activity
namespace: molecular_function
def: "Isoenergetic transfer of FAT10 from one protein to another via the reaction X-FAT10 + Y -> Y-FAT10 + X, where both the X-FAT10 and Y-FAT10 linkages are thioester bonds between the C-terminal amino acid of FAT10 and a sulfhydryl side group of a cysteine residue." [GOC:dph]
synonym: "E2" RELATED [GOC:dph]
is_a: GO:0019775 ! FAT10 transferase activity
is_a: GO:0061650 ! ubiquitin-like protein conjugating enzyme activity
created_by: dph
creation_date: 2014-11-06T13:21:50Z

[Term]
id: GO:0061653
name: ISG15 conjugating enzyme activity
namespace: molecular_function
def: "Isoenergetic transfer of ISG15 from one protein to another via the reaction X-ISG15 + Y -> Y-ISG15 + X, where both the X-ISG15 and Y-ISG15 linkages are thioester bonds between the C-terminal amino acid of ISG15 and a sulfhydryl side group of a cysteine residue." [GOC:dph]
synonym: "E2" RELATED [GOC:dph]
is_a: GO:0042296 ! ISG15 transferase activity
is_a: GO:0061650 ! ubiquitin-like protein conjugating enzyme activity
created_by: dph
creation_date: 2014-11-06T13:24:50Z

[Term]
id: GO:0061654
name: NEDD8 conjugating enzyme activity
namespace: molecular_function
def: "Isoenergetic transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y -> Y-NEDD8 + X, where both the X-NEDD8 and Y-NEDD8 linkages are thioester bonds between the C-terminal amino acid of NEDD8 and a sulfhydryl side group of a cysteine residue." [GOC:dph]
synonym: "E2" RELATED [GOC:dph]
is_a: GO:0019788 ! NEDD8 transferase activity
is_a: GO:0061650 ! ubiquitin-like protein conjugating enzyme activity
created_by: dph
creation_date: 2014-11-06T13:27:56Z

[Term]
id: GO:0061655
name: Pup conjugating enzyme activity
namespace: molecular_function
def: "Isoenergetic transfer of Pup from one protein to another via the reaction X-Pup + Y -> Y-Pup + X, where both the X-Pup and Y-Pup linkages are thioester bonds between the C-terminal amino acid of Pup and a sulfhydryl side group of a cysteine residue." [GOC:dph]
synonym: "E2" RELATED [GOC:dph]
is_a: GO:0061650 ! ubiquitin-like protein conjugating enzyme activity
is_a: GO:0072496 ! Pup transferase activity
created_by: dph
creation_date: 2014-11-06T13:30:46Z

[Term]
id: GO:0061656
name: SUMO conjugating enzyme activity
namespace: molecular_function
def: "Isoenergetic transfer of SUMO from one protein to another via the reaction X-SUMO + Y -> Y-SUMO + X, where both the X-SUMO and Y-SUMO linkages are thioester bonds between the C-terminal amino acid of SUMO and a sulfhydryl side group of a cysteine residue." [GOC:dph]
synonym: "E2" RELATED [GOC:dph]
is_a: GO:0019789 ! SUMO transferase activity
is_a: GO:0061650 ! ubiquitin-like protein conjugating enzyme activity
created_by: dph
creation_date: 2014-11-06T13:33:20Z

[Term]
id: GO:0061657
name: UFM1 conjugating enzyme activity
namespace: molecular_function
def: "Isoenergetic transfer of UFM1 from one protein to another via the reaction X-UFM1 + Y -> Y-UFM1 + X, where both the X-UFM1 and Y-UFM1 linkages are thioester bonds between the C-terminal amino acid of UFM1 and a sulfhydryl side group of a cysteine residue." [GOC:dph]
synonym: "E2" RELATED [GOC:dph]
is_a: GO:0061650 ! ubiquitin-like protein conjugating enzyme activity
is_a: GO:0071568 ! UFM1 transferase activity
created_by: dph
creation_date: 2014-11-06T13:35:13Z

[Term]
id: GO:0061658
name: URM1 conjugating enzyme activity
namespace: molecular_function
def: "Isoenergetic transfer of URM1 from one protein to another via the reaction X-URM1 + Y -> Y-URM1 + X, where both the X-URM1 and Y-URM1 linkages are thioester bonds between the C-terminal amino acid of URM1 and a sulfhydryl side group of a cysteine residue." [GOC:dph]
synonym: "E2" RELATED [GOC:dph]
is_a: GO:0042294 ! URM1 transferase activity
is_a: GO:0061650 ! ubiquitin-like protein conjugating enzyme activity
created_by: dph
creation_date: 2014-11-06T13:37:26Z

[Term]
id: GO:0061659
name: ubiquitin-like protein ligase activity
namespace: molecular_function
def: "Catalysis of the transfer of a ubiquitin-like protein (ULP) to a substrate protein via the reaction X-ULP + S --> X + S-ULP, where X is either an E2 or E3 enzyme, the X-ULP linkage is a thioester bond, and the S-ULP linkage is an isopeptide bond between the C-terminal glycine of ULP and the epsilon-amino group of lysine residues in the substrate." [GOC:dph]
synonym: "E3" RELATED [GOC:dph]
synonym: "small conjugating protein ligase activity" EXACT [GOC:dph]
is_a: GO:0019787 ! ubiquitin-like protein transferase activity
created_by: dph
creation_date: 2014-11-06T13:46:23Z

[Term]
id: GO:0061660
name: Atg12 ligase activity
namespace: molecular_function
def: "Catalysis of the transfer of Atg12 to a substrate protein via the reaction X-Atg12 + S --> X + S-Atg12, where X is either an E2 or E3 enzyme, the X-Atg12 linkage is a thioester bond, and the S-Atg12 linkage is an isopeptide bond between the C-terminal amino acid of Atg12 and the epsilon-amino group of lysine residues in the substrate." [GOC:dph]
synonym: "E3" RELATED [GOC:dph]
is_a: GO:0019777 ! Atg12 transferase activity
is_a: GO:0061659 ! ubiquitin-like protein ligase activity
created_by: dph
creation_date: 2014-11-06T13:50:42Z

[Term]
id: GO:0061661
name: FAT10 ligase activity
namespace: molecular_function
def: "Catalysis of the transfer of FAT10 to a substrate protein via the reaction X-FAT10 + S --> X + S-FAT10, where X is either an E2 or E3 enzyme, the X-FAT10 linkage is a thioester bond, and the S-FAT10 linkage is an isopeptide bond between the C-terminal glycine of FAT10 and the epsilon-amino group of lysine residues in the substrate." [GOC:dph]
synonym: "E3" RELATED [GOC:dph]
is_a: GO:0019775 ! FAT10 transferase activity
is_a: GO:0061659 ! ubiquitin-like protein ligase activity
created_by: dph
creation_date: 2014-11-06T13:53:10Z

[Term]
id: GO:0061662
name: ISG15 ligase activity
namespace: molecular_function
def: "Catalysis of the transfer of a ISG15 to a substrate protein via the reaction X-ISG15 + S --> X + S-ISG15, where X is either an E2 or E3 enzyme, the X-ISG15 linkage is a thioester bond, and the S-ISG15 linkage is an isopeptide bond between the C-terminal amino acid of ISG15 and the epsilon-amino group of lysine residues in the substrate." [GOC:dph]
synonym: "E3" RELATED [GOC:dph]
is_a: GO:0042296 ! ISG15 transferase activity
is_a: GO:0061659 ! ubiquitin-like protein ligase activity
created_by: dph
creation_date: 2014-11-06T13:54:48Z

[Term]
id: GO:0061663
name: NEDD8 ligase activity
namespace: molecular_function
def: "Catalysis of the transfer of NEDD8 to a substrate protein via the reaction X-NEDD8 + S --> X + S-NEDD8, where X is either an E2 or E3 enzyme, the X-NEDD8 linkage is a thioester bond, and the S-NEDD8 linkage is an isopeptide bond between the C-terminal amino acid of NEDD8 and the epsilon-amino group of lysine residues in the substrate." [GOC:dph]
synonym: "E3" RELATED [GOC:dph]
is_a: GO:0019788 ! NEDD8 transferase activity
is_a: GO:0061659 ! ubiquitin-like protein ligase activity
created_by: dph
creation_date: 2014-11-06T13:57:00Z

[Term]
id: GO:0061664
name: Pup ligase activity
namespace: molecular_function
def: "Catalysis of the transfer of Pup to a substrate protein via the reaction X-Pup + S --> X + S-Pup, where X is either an E2 or E3 enzyme, the X-Pup linkage is a thioester bond, and the S-Pup linkage is an isopeptide bond between the C-terminal amino acid of Pup and the epsilon-amino group of lysine residues in the substrate." [GOC:dph]
synonym: "E3" RELATED [GOC:dph]
is_a: GO:0061659 ! ubiquitin-like protein ligase activity
is_a: GO:0072496 ! Pup transferase activity
created_by: dph
creation_date: 2014-11-06T13:59:09Z

[Term]
id: GO:0061665
name: SUMO ligase activity
namespace: molecular_function
def: "Catalysis of the transfer of SUMO to a substrate protein via the reaction X-SUMO + S --> X + S-SUMO, where X is either an E2 or E3 enzyme, the X-SUMO linkage is a thioester bond, and the S-SUMO linkage is an isopeptide bond between the C-terminal amino acid of SUMO and the epsilon-amino group of lysine residues in the substrate." [GOC:dph]
synonym: "E3" RELATED [GOC:dph]
is_a: GO:0019789 ! SUMO transferase activity
is_a: GO:0061659 ! ubiquitin-like protein ligase activity
created_by: dph
creation_date: 2014-11-06T14:00:44Z

[Term]
id: GO:0061666
name: UFM1 ligase activity
namespace: molecular_function
def: "Catalysis of the transfer of UFM1 to a substrate protein via the reaction X-UFM1 + S --> X + S-UFM1, where X is either an E2 or E3 enzyme, the X-UFM1 linkage is a thioester bond, and the S-UFM1 linkage is an isopeptide bond between the C-terminal amino acid of UFM1 and the epsilon-amino group of lysine residues in the substrate." [GOC:dph]
synonym: "E3" RELATED [GOC:dph]
is_a: GO:0061659 ! ubiquitin-like protein ligase activity
is_a: GO:0071568 ! UFM1 transferase activity
created_by: dph
creation_date: 2014-11-06T14:02:37Z

[Term]
id: GO:0061667
name: URM1 ligase activity
namespace: molecular_function
def: "Catalysis of the transfer of URM1 to a substrate protein via the reaction X-URM1 + S --> X + S-URM1, where X is either an E2 or E3 enzyme, the X-URM1 linkage is a thioester bond, and the S-URM1 linkage is an isopeptide bond between the C-terminal amino acid of URM1 and the epsilon-amino group of lysine residues in the substrate." [GOC:dph]
synonym: "E3" RELATED [GOC:dph]
is_a: GO:0042294 ! URM1 transferase activity
is_a: GO:0061659 ! ubiquitin-like protein ligase activity
created_by: dph
creation_date: 2014-11-06T14:04:43Z

[Term]
id: GO:0061668
name: mitochondrial ribosome assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of the mitochondrial ribosome and of its subunits." [GOC:dph]
is_a: GO:0042255 ! ribosome assembly
created_by: dph
creation_date: 2014-11-07T15:32:20Z

[Term]
id: GO:0061669
name: spontaneous neurotransmitter secretion
namespace: biological_process
def: "Neurotransmitter secretion that occurs in the absence of the action of a secretagogue or a presynaptic action potential." [GOC:dph, GOC:pad, GOC:PARL, PMID:21334193]
subset: goslim_synapse
synonym: "stimulus-independent neurotransmitter secretion" EXACT [GOC:dph]
is_a: GO:0007269 ! neurotransmitter secretion
relationship: part_of GO:0098814 ! spontaneous synaptic transmission
created_by: dph
creation_date: 2014-11-17T07:52:35Z

[Term]
id: GO:0061670
name: evoked neurotransmitter secretion
namespace: biological_process
def: "Neurotransmitter secretion that occurs in the presence of the action of a secretagogue or a presynaptic action potential." [GOC:dph, GOC:pad, GOC:PARL, PMID:21334193]
synonym: "stimulus-dependant neurotransmitter secretion" EXACT [GOC:dph]
is_a: GO:0007269 ! neurotransmitter secretion
created_by: dph
creation_date: 2014-11-17T08:06:21Z

[Term]
id: GO:0061671
name: Cbp3p-Cbp6 complex
namespace: cellular_component
def: "A protein complex located at the mitochondrial ribosome tunnel exit that is involved in efficient translation and protein complex assembly." [GOC:dph, GOC:rb, PMID:21670217]
is_a: GO:0043234 ! protein complex
created_by: dph
creation_date: 2014-11-18T15:08:30Z

[Term]
id: GO:0061672
name: glutathione hydrolase complex
namespace: cellular_component
def: "Enzyme complex that in S. cerevisiae has components Dug2/Dug3 and is able to catalyze the cleavage of glutathione into glutamate and Cys-Gly." [GOC:dph]
synonym: "gamma-glutamyltranspeptidase complex" EXACT [GOC:dph]
synonym: "glutamine amidotransferase II complex" NARROW [PMID:22277648]
synonym: "glutathionase complex" EXACT [GOC:dph]
is_a: GO:1902494 ! catalytic complex
created_by: dph
creation_date: 2014-11-24T14:38:08Z

[Term]
id: GO:0061673
name: mitotic spindle astral microtubule
namespace: cellular_component
def: "Any of the mitotic spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell." [GOC:dph]
is_a: GO:0000235 ! astral microtubule
intersection_of: GO:0000235 ! astral microtubule
intersection_of: part_of GO:0072686 ! mitotic spindle
relationship: part_of GO:0072686 ! mitotic spindle
created_by: dph
creation_date: 2014-12-08T18:27:20Z

[Term]
id: GO:0061674
name: gap filling involved in double-strand break repair via nonhomologous end joining
namespace: biological_process
def: "Repair of the gaps in the DNA helix using a discontinuous template during double-strand break repair via nonhomologous end joining." [GOC:dph]
is_a: GO:0006259 ! DNA metabolic process
relationship: part_of GO:0006303 ! double-strand break repair via nonhomologous end joining
created_by: dph
creation_date: 2015-01-05T10:07:32Z

[Term]
id: GO:0061675
name: RBL family protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any member of the rhamnose-binding lectin (RBL) family, a family of animal lectins that show specific binding activities to L-rhamnose or D-galactose." [PMID:22312473]
synonym: "rhamnose-binding lectin family protein binding" EXACT []
is_a: GO:0005515 ! protein binding
created_by: dph
creation_date: 2015-01-10T18:22:42Z

[Term]
id: GO:0061676
name: importin-alpha family protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any member of the importin-alpha family." [PMID:15350979, PMID:17170104, PMID:23734157]
is_a: GO:0005515 ! protein binding
created_by: dph
creation_date: 2015-01-10T18:25:22Z

[Term]
id: GO:0061677
name: 2-dehydro-3-deoxy-D-gluconate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate <=> pyruvate + D-glyceraldehyde." [EC:4.1.2.51, GOC:dph]
xref: EC:4.1.2.51
xref: MetaCyc:4.1.2.51-RXN
xref: RHEA:35586
is_a: GO:0016832 ! aldehyde-lyase activity
created_by: dph
creation_date: 2015-01-15T13:46:25Z

[Term]
id: GO:0061678
name: Entner-Doudoroff pathway
namespace: biological_process
def: "A cellular carbohydrate catabolic process that converts a carbohydrate to pyruvate and either glyceraldehyde or glyceraldehyde-3 phosphate by dehydration and aldol cleavage via a gluconate or 6-phosphogluconate intermediate." [GOC:dph, PMID:12921536]
xref: MetaCyc:Entner-Doudoroff-Pathways
is_a: GO:0006090 ! pyruvate metabolic process
is_a: GO:0044275 ! cellular carbohydrate catabolic process
is_a: GO:0044724 ! single-organism carbohydrate catabolic process
created_by: dph
creation_date: 2015-01-16T15:28:25Z

[Term]
id: GO:0061679
name: Entner-Doudoroff pathway through gluconate
namespace: biological_process
def: "The Entner-Doudoroff pathway that proceeds through a D-gluconate intermediate." [GOC:dph, PMID:12921536]
is_a: GO:0061678 ! Entner-Doudoroff pathway
relationship: has_part GO:0047929 ! gluconate dehydratase activity
relationship: has_part GO:0047935 ! glucose 1-dehydrogenase (NADP+) activity
created_by: dph
creation_date: 2015-01-16T15:41:22Z

[Term]
id: GO:0061680
name: Entner-Doudoroff pathway through gluconate to D-glyceraldehyde
namespace: biological_process
def: "The Entner-Doudoroff pathway that proceeds through a D-gluconate intermediate and yields pyruvate and D-glyceraldehyde." [GOC:dph, MetaCyc:ENTNER-DOUDOROFF-PWY-II, PMID:12921536]
xref: MetaCyc:ENTNER-DOUDOROFF-PWY-II
is_a: GO:0005996 ! monosaccharide metabolic process
is_a: GO:0061679 ! Entner-Doudoroff pathway through gluconate
created_by: dph
creation_date: 2015-01-22T08:51:31Z

[Term]
id: GO:0061681
name: Entner-Doudoroff pathway through gluconate to D-glyceraldehyde-3-phosphate
namespace: biological_process
def: "The Entner-Doudoroff pathway that proceeds through a D-gluconate intermediate and yields pyruvate and D-glyceraldehyde-3-phosphate." [GOC:dph, MetaCyc:ENTNER-DOUFDOROFF-PWY-III, PMID:12921536]
xref: MetaCyc:ENTNER-DOUDOROFF-PWY-III
is_a: GO:0019682 ! glyceraldehyde-3-phosphate metabolic process
is_a: GO:0061679 ! Entner-Doudoroff pathway through gluconate
relationship: has_part GO:0008673 ! 2-dehydro-3-deoxygluconokinase activity
created_by: dph
creation_date: 2015-01-22T08:55:22Z

[Term]
id: GO:0061682
name: seminal vesicle morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a seminal vesicle are generated and organized." [GOC:dph]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0022612 ! gland morphogenesis
is_a: GO:0044702 ! single organism reproductive process
relationship: part_of GO:0061107 ! seminal vesicle development
created_by: dph
creation_date: 2015-03-04T13:33:49Z

[Term]
id: GO:0061683
name: branching involved in seminal vesicle morphogenesis
namespace: biological_process
def: "The process in which the branching structure of the seminal vesicle is generated and organized. A branch is a division or offshoot from a main stem." [GOC:dph, PMID:16916376]
synonym: "gonecyst branching morphogenesis" EXACT [GOC:dph]
synonym: "seminal gland branching morphogenesis" EXACT [GOC:dph]
synonym: "seminal vesicle branching" EXACT [GOC:dph]
synonym: "seminal vesicle branching morphogenesis" EXACT [GOC:dph]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0061138 ! morphogenesis of a branching epithelium
intersection_of: GO:0061138 ! morphogenesis of a branching epithelium
intersection_of: part_of GO:0061682 ! seminal vesicle morphogenesis
relationship: part_of GO:0061108 ! seminal vesicle epithelium development
relationship: part_of GO:0061682 ! seminal vesicle morphogenesis
created_by: dph
creation_date: 2015-03-04T13:39:47Z

[Term]
id: GO:0061684
name: chaperone-mediated autophagy
namespace: biological_process
def: "The autophagy process which begins when chaperones and co-chaperones recognize a KFERQ-related motif and unfold the substrate protein. The process ends with the catabolism of the protein in the lysosome." [GOC:pad, GOC:PARL, PMID:22743996]
synonym: "CMA" RELATED [PMID:22743996]
xref: Wikipedia:Chaperone-mediated_autophagy
is_a: GO:0006914 ! autophagy
relationship: has_part GO:0005102 ! receptor binding
relationship: has_part GO:0072321 ! chaperone-mediated protein transport
created_by: dph
creation_date: 2015-03-04T14:35:26Z

[Term]
id: GO:0061685
name: diphthine methylesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: diphthine methyl ester + H2O <=> diphthine + H+ + methanol." [GOC:dph, PMID:24739148, RHEA:42659]
xref: EC:3.1.1.97
xref: RHEA:42659
is_a: GO:0052689 ! carboxylic ester hydrolase activity
created_by: dph
creation_date: 2015-03-04T16:00:21Z

[Term]
id: GO:0061686
name: hercynylcysteine sulfoxide synthase
namespace: molecular_function
def: "Catalysis of the reaction: L-cysteine + N-alpha,N-alpha,N-alpha-trimethyl-L-histidine + O2 <=> hercynylcysteine sulfoxide + H2O." [GOC:dph, PMID:28577]
synonym: "hercynylcysteine S-oxide synthase" EXACT [GOC:dph]
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
relationship: part_of GO:0052699 ! ergothioneine biosynthetic process
created_by: dph
creation_date: 2015-03-06T15:08:51Z

[Term]
id: GO:0061687
name: detoxification of inorganic compound
namespace: biological_process
def: "Any process that reduces or removes the toxicity of inorganic compounds. These include transport of such compounds away from sensitive areas and to compartments or complexes whose purpose is sequestration of inorganic compounds." [GOC:vw]
is_a: GO:0098754 ! detoxification
created_by: dph
creation_date: 2015-03-09T09:16:23Z

[Term]
id: GO:0061688
name: glycolytic process via Entner-Doudoroff Pathway
namespace: biological_process
def: "A glycolytic process in which the glucose is catabolized to pyruvate by first entering the Entner-Doudoroff pathway to yield pyruvate and glyceraldehyde-3-phosphate. The glyceraldehyde-3-phosphate is subsequently converted to pyruvate by the core glycolytic enzymes." [GOC:dph, PMID:9657988]
is_a: GO:0006096 ! glycolytic process
created_by: dph
creation_date: 2015-03-12T14:39:00Z

[Term]
id: GO:0061689
name: tricellular tight junction
namespace: cellular_component
def: "An specialized occluding junction where three epithelial cells meet. It is composed of a branching network of sealing strands that run perpendicularly to the bicellular tight junction at the point of contact between three epithelial cells in an epithelial sheet." [GOC:dk, GOC:dph, PMID:22520461, PMID:25822906]
is_a: GO:0070160 ! occluding junction
created_by: dph
creation_date: 2015-04-12T10:34:19Z

[Term]
id: GO:0061690
name: lipoamidase activity
namespace: molecular_function
def: "Catalysis of the cleavage of the amide bond to release lipoic acid from a lipoylated protein." [GOC:dph, PMID:14086741]
synonym: "lipoyl-X-hydrolase" EXACT [PMID:14086741]
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
created_by: dph
creation_date: 2015-05-05T10:06:49Z

[Term]
id: GO:0061691
name: detoxification of hydrogen peroxide
namespace: biological_process
def: "Any process that reduces or removes the toxicity of hydrogen peroxide. These include transport of hydrogen peroxide away from sensitive areas and to compartments or complexes whose purpose is sequestration." [GOC:dph]
is_a: GO:0042743 ! hydrogen peroxide metabolic process
is_a: GO:0061687 ! detoxification of inorganic compound
relationship: part_of GO:0042542 ! response to hydrogen peroxide
created_by: dph
creation_date: 2015-05-05T12:42:18Z

[Term]
id: GO:0061692
name: cellular detoxification of hydrogen peroxide
namespace: biological_process
def: "Any process that reduces or removes the toxicity of hydrogen peroxide in a cell. These include transport of hydrogen peroxide away from sensitive areas and to compartments or complexes whose purpose is sequestration." [GOC:dph, GOC:vw]
is_a: GO:0061691 ! detoxification of hydrogen peroxide
is_a: GO:0098869 ! cellular oxidant detoxification
relationship: part_of GO:0070301 ! cellular response to hydrogen peroxide
created_by: dph
creation_date: 2015-05-05T12:46:20Z

[Term]
id: GO:0061693
name: alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + methylphosphonate = alpha-D-ribose 1-methylphosphonate 5-triphosphate + adenine." [EC:2.7.8.37, GOC:dph, PMID:22089136]
xref: EC:2.7.8.37
xref: MetaCyc:RXN0-6732
xref: RHEA:34682
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups
created_by: dph
creation_date: 2015-05-06T10:04:04Z

[Term]
id: GO:0061694
name: alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase complex
namespace: cellular_component
def: "A catalytic protein complex that is capable of alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity." [GOC:dph, PMID:22089136]
comment: An example of this complex is PhnI (P16687) in Escherichia coli.
is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups
created_by: dph
creation_date: 2015-05-06T10:12:02Z

[Term]
id: GO:0061695
name: transferase complex, transferring phosphorus-containing groups
namespace: cellular_component
def: "A transferase complex capable of catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:bhm, GOC:dph]
is_a: GO:1990234 ! transferase complex
created_by: dph
creation_date: 2015-05-06T11:22:38Z

[Term]
id: GO:0061696
name: pituitary gonadotropin complex
namespace: cellular_component
def: "A protein complex that is a protein hormone secreted by gonadotrope cells of the anterior pituitary of vertebrates. capable of regulating normal growth, sexual development, and reproductive function." [GOC:dph, PMID:11420129]
is_a: GO:0043234 ! protein complex
is_a: GO:0044421 ! extracellular region part
created_by: dph
creation_date: 2015-05-06T13:11:18Z

[Term]
id: GO:0061697
name: protein-glutaryllysine deglutarylase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein-glutaryllysine + H2O => protein-lysine + glutarate. This reaction is the removal of a glutaryl group from a glutarylated lysine residue of a protein or peptide." [GOC:dph, PMID:24703693]
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
relationship: part_of GO:0061699 ! peptidyl-lysine deglutarylation
created_by: dph
creation_date: 2015-05-07T10:55:53Z

[Term]
id: GO:0061698
name: protein deglutarylation
namespace: biological_process
def: "The removal of a glutaryl group (CO-CH2-CH2-CH2-CO) from a residue in a peptide or protein." [GOC:dph, PMID:24703693]
is_a: GO:0035601 ! protein deacylation
created_by: dph
creation_date: 2015-05-07T11:02:31Z

[Term]
id: GO:0061699
name: peptidyl-lysine deglutarylation
namespace: biological_process
def: "The removal of a glutaryl group (CO-CH2-CH2--CH2-CO) from a glutarylated lysine residue in a peptide or protein." [GOC:dph, PMID:24703693]
is_a: GO:0061698 ! protein deglutarylation
created_by: dph
creation_date: 2015-05-07T11:04:42Z

[Term]
id: GO:0061700
name: GATOR2 complex
namespace: cellular_component
def: "A multiprotein subcomplex of GATOR that regulates mTOR signaling by interacting with the Rag GTPases. In humans this complex consists of Mios, WDR24, WDR59, Seh1L, Sec13." [GOC:rb, PMID:23723238]
is_a: GO:0043234 ! protein complex
relationship: part_of GO:0035859 ! Seh1-associated complex
created_by: dph
creation_date: 2015-05-07T11:13:27Z

[Term]
id: GO:0061701
name: bacterial outer membrane vesicle
namespace: cellular_component
def: "A spherical, bilayered proteolipid vesicle released from gram-negative bacterial outer membranes." [GOC:dph, GOC:pr, PMID:20596524]
is_a: GO:1903561 ! extracellular vesicle
created_by: dph
creation_date: 2015-05-07T13:53:47Z

[Term]
id: GO:0061702
name: inflammasome complex
namespace: cellular_component
def: "A cytosolic protein complex that is capable of activating caspase-1." [GOC:dph, PMID:17599095]
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part
created_by: dph
creation_date: 2015-05-08T14:30:54Z

[Term]
id: GO:0061703
name: pyroptosome complex
namespace: cellular_component
def: "A protein complex that consists of an assemble of ASC dimers that is capable of inducing pyroptosis." [GOC:dph, PMID:17599095]
synonym: "ASC pyroptosome" EXACT [PMID:17599095]
is_a: GO:0043234 ! protein complex
created_by: dph
creation_date: 2015-05-08T14:43:37Z

[Term]
id: GO:0061704
name: glycolytic process from sucrose
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a sucrose into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:dph, GOC:glycolysis, PMID:15012287]
is_a: GO:0005987 ! sucrose catabolic process
is_a: GO:0006096 ! glycolytic process
created_by: dph
creation_date: 2015-06-11T13:26:28Z

[Term]
id: GO:0061705
name: sucrose catabolic process to fructose-6-phosphate through glucose and fructose
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of sucrose, to yield fructose-6-phosphate through both glucose and fructose intermediates." [GOC:dph, GOC:glycolysis, MetaCyc:PWY-621, PMID:15012287]
xref: MetaCyc:PWY-621
is_a: GO:0005987 ! sucrose catabolic process
relationship: has_part GO:0004340 ! glucokinase activity
relationship: has_part GO:0008865 ! fructokinase activity
created_by: dph
creation_date: 2015-06-11T13:32:05Z

[Term]
id: GO:0061706
name: glycolytic process from sucrose through glucose and fructose
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of sucrose into pyruvate through both glucose and fructose intermediates, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:dph, GOC:glycolysis, MetaCyc:PWY-1042, PMID:15012287]
xref: MetaCyc:PWY-1042
is_a: GO:0061620 ! glycolytic process through glucose-6-phosphate
is_a: GO:0061704 ! glycolytic process from sucrose
created_by: dph
creation_date: 2015-06-11T13:40:32Z

[Term]
id: GO:0061707
name: extracellular exosome macropinocytosis
namespace: biological_process
def: "The single-organism macropinocytosis process that results in the uptake of an extracellular exosome." [GOC:dph, PMID:24951588]
is_a: GO:0051650 ! establishment of vesicle localization
is_a: GO:1902538 ! single-organism macropinocytosis
is_a: GO:1902580 ! single-organism cellular localization
created_by: dph
creation_date: 2015-06-15T16:02:38Z

[Term]
id: GO:0061708
name: tRNA-5-taurinomethyluridine 2-sulfurtransferase
namespace: molecular_function
def: "Catalysis of 5-taurinomethyluridine in tRNA + a [protein]-S-sulfanylcysteine + ATP + a reduced electron acceptor = a 5-taurinomethyl-2-thiouridine in tRNA + a [protein]-L-cysteine + AMP + an oxidized electron acceptor + diphosphate + H+." [GOC:dph, PMID:15509579]
xref: MetaCyc:RXN-16821
is_a: GO:0016783 ! sulfurtransferase activity
created_by: dph
creation_date: 2015-06-16T09:02:23Z

[Term]
id: GO:0061709
name: reticulophagy
namespace: biological_process
alt_id: GO:1990766
def: "The autophagic process in which parts of the endoplasmic reticulum are loaded into autophagosomes, delivered to the vacuole, and degraded in response to changing cellular conditions." [GOC:autophagy, GOC:dph, PMID:22481944, PMID:24060720, PMID:26040717]
synonym: "autophagy of the endoplasmic reticulum" EXACT []
synonym: "autophagy of the ER" EXACT []
synonym: "endoplasmic reticulum degradation" RELATED []
synonym: "ER degradation" RELATED []
synonym: "ER-phagy" EXACT []
is_a: GO:0016236 ! macroautophagy
is_a: GO:1903008 ! organelle disassembly
created_by: dph
creation_date: 2015-06-18T15:15:48Z

[Term]
id: GO:0061710
name: L-threonylcarbamoyladenylate synthase
namespace: molecular_function
def: "Catalysis of the reaction:  L-threonine + ATP + bicarbonate = L-threonylcarbamoyladenylate + diphosphate + H(2)O." [EC:2.7.7.87]
xref: EC:2.7.7.87
xref: MetaCyc:RXN-14569
xref: RHEA:36410
is_a: GO:0016779 ! nucleotidyltransferase activity
created_by: dph
creation_date: 2015-06-23T08:25:14Z

[Term]
id: GO:0061711
name: N(6)-L-threonylcarbamoyladenine synthase
namespace: molecular_function
def: "Catalysis of the reaction: L-threonylcarbamoyladenylate + adenine(37) in tRNA = AMP + N(6)-L-threonylcarbamoyladenine(37) in tRNA." [EC:2.3.1.234]
xref: EC:2.3.1.234
xref: MetaCyc:RXN-14570
xref: RHEA:37062
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups
created_by: dph
creation_date: 2015-06-23T08:34:44Z

[Term]
id: GO:0061712
name: tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase
namespace: molecular_function
def: "Catalysis of the reaction: N(6)-L-threonylcarbamoyladenine(37) in tRNA + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = 2-methylthio-N(6)-L-threonylcarbamoyladenine(37) in tRNA + S-adenosyl-L-homocysteine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine." [EC:2.8.4.5]
xref: EC:2.8.4.5
xref: MetaCyc:RXN-14531
xref: RHEA:37078
is_a: GO:0050497 ! transferase activity, transferring alkylthio groups
created_by: dph
creation_date: 2015-06-23T08:47:10Z

[Term]
id: GO:0061713
name: anterior neural tube closure
namespace: biological_process
def: "The step in the formation of the neural tube, where the paired anterior neural folds are brought together and fuse at the dorsal midline." [GOC:BHF, GOC:dph, GOC:hal, PMID:17286298]
is_a: GO:0060606 ! tube closure
relationship: part_of GO:0001843 ! neural tube closure
created_by: dph
creation_date: 2015-06-23T10:13:41Z

[Term]
id: GO:0061714
name: folic acid receptor activity
namespace: molecular_function
def: "Combining selectively with extracellular folic acid and delivering it into the cell via endocytosis." [GOC:BHF, GOC:hal]
synonym: "folate receptor activity" EXACT []
is_a: GO:0038024 ! cargo receptor activity
relationship: has_part GO:0005542 ! folic acid binding
relationship: part_of GO:0071231 ! cellular response to folic acid
created_by: dph
creation_date: 2015-06-23T13:36:07Z

[Term]
id: GO:0061715
name: miRNA 2'-O-methylation
namespace: biological_process
def: "The posttranscriptional addition of a methyl group to the 2' oxygen atom of a nucleotide residue in an miRNA molecule." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:20705645]
is_a: GO:0001510 ! RNA methylation
is_a: GO:0010586 ! miRNA metabolic process
created_by: dph
creation_date: 2015-06-29T08:41:03Z

[Term]
id: GO:0061716
name: miRNA export from nucleus
namespace: biological_process
def: "The directed movement of a processed miRNA from the nucleus to the cytoplasm." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:15738428, PMID:21554756]
is_a: GO:0006405 ! RNA export from nucleus
is_a: GO:1990428 ! miRNA transport
created_by: dph
creation_date: 2015-06-29T08:54:41Z

[Term]
id: GO:0061717
name: miRNA transporter activity
namespace: molecular_function
def: "Enables the directed movement of cleaved miRNAs between the nucleus and the cytoplasm of a cell." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:15738428, PMID:21554756]
is_a: GO:0005487 ! nucleocytoplasmic transporter activity
created_by: dph
creation_date: 2015-06-29T08:59:16Z

[Term]
id: GO:0061718
name: glucose catabolic process to pyruvate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glucose, with the production of pyruvate." [GOC:dph]
synonym: "glucose catabolism to pyruvate" EXACT [GOC:dph]
is_a: GO:0006007 ! glucose catabolic process
is_a: GO:0006090 ! pyruvate metabolic process
created_by: dph
creation_date: 2015-06-30T13:17:26Z

[Term]
id: GO:0061719
name: glucose catabolic process to pyruvate utilizing ADP
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glucose into pyruvate, with the concomitant production of a small amount of ATP and the utilization of ADP in the initial kinase reactions." [GOC:dph, MetaCyc:P341-PWY]
xref: MetaCyc:P341-PWY
is_a: GO:0006091 ! generation of precursor metabolites and energy
is_a: GO:0061718 ! glucose catabolic process to pyruvate
relationship: has_part GO:0004332 ! fructose-bisphosphate aldolase activity
relationship: has_part GO:0004347 ! glucose-6-phosphate isomerase activity
relationship: has_part GO:0004618 ! phosphoglycerate kinase activity
relationship: has_part GO:0004619 ! phosphoglycerate mutase activity
relationship: has_part GO:0004807 ! triose-phosphate isomerase activity
relationship: has_part GO:0043797 ! glyceraldehyde-3-phosphate dehydrogenase (ferredoxin) activity
relationship: has_part GO:0043844 ! ADP-specific phosphofructokinase activity
created_by: dph
creation_date: 2015-06-30T13:23:42Z

[Term]
id: GO:0061720
name: 6-sulfoquinovose(1-) catabolic process to glycerone phosphate and 3-sulfolactaldehyde
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 6-sulfoquinovose(1-) resulting in the formation of glycerone phosphate (DHAP) and 3-sulfolactaldehyde (SLA)." [GOC:dph, PMID:24463506]
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:0042180 ! cellular ketone metabolic process
is_a: GO:0044712 ! single-organism catabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process
is_a: GO:1902777 ! 6-sulfoquinovose(1-) catabolic process
relationship: has_part GO:0061594 ! 6-deoxy-6-sulfofructose kinase activity
created_by: dph
creation_date: 2015-07-01T08:47:30Z

[Term]
id: GO:0061721
name: 6-sulfoquinovose(1-) catabolic process to 3-sulfopropanediol(1-)
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 6-sulfoquinovose(1-) resulting in the formation of glycerone phosphate (DHAP) and 3-sulfopropanediol(1-)." [GOC:dph, PMID:14602517, PMID:24463506]
xref: MetaCyc:PWY-7446
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:0042180 ! cellular ketone metabolic process
is_a: GO:0044712 ! single-organism catabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process
is_a: GO:1902777 ! 6-sulfoquinovose(1-) catabolic process
created_by: dph
creation_date: 2015-07-01T09:20:08Z

[Term]
id: GO:0061722
name: sulphoglycolysis
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 6-sulfoquinovose(1-) resulting in the formation of glycerone phosphate (DHAP) and pyruvate." [GOC:dph, PMID:24463506]
synonym: "sulfoglycolysis" EXACT [PMID:14602597]
is_a: GO:0006090 ! pyruvate metabolic process
is_a: GO:0006735 ! NADH regeneration
is_a: GO:0006757 ! ATP generation from ADP
is_a: GO:0042180 ! cellular ketone metabolic process
is_a: GO:0044712 ! single-organism catabolic process
is_a: GO:1902777 ! 6-sulfoquinovose(1-) catabolic process
relationship: has_part GO:0004365 ! glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
relationship: has_part GO:0004618 ! phosphoglycerate kinase activity
relationship: has_part GO:0004619 ! phosphoglycerate mutase activity
relationship: has_part GO:0004634 ! phosphopyruvate hydratase activity
relationship: has_part GO:0004807 ! triose-phosphate isomerase activity
created_by: dph
creation_date: 2015-07-01T09:44:30Z

[Term]
id: GO:0061723
name: glycophagy
namespace: biological_process
def: "The autophagic process in which cellular glycogen is delivered to the vacuole and degraded in response to changing cellular conditions." [PMID:21893048]
is_a: GO:0016236 ! macroautophagy
created_by: dph
creation_date: 2015-07-08T13:36:51Z

[Term]
id: GO:0061724
name: lipophagy
namespace: biological_process
def: "The autophagic process in which lipid droplets are delivered to the vacuole and degraded in response to changing cellular conditions." [GOC:autophagy, PMID:23708524, PMID:26076903]
is_a: GO:0016236 ! macroautophagy
is_a: GO:0033993 ! response to lipid
is_a: GO:0044242 ! cellular lipid catabolic process
created_by: dph
creation_date: 2015-07-08T13:38:19Z

[Term]
id: GO:0061725
name: cytosolic lipolysis
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lipid droplets and hydrolysis of stored triglycerides occurring through the orchestrated activation of cytosolic lipases." [GOC:autophagy]
is_a: GO:0044242 ! cellular lipid catabolic process
relationship: occurs_in GO:0005829 ! cytosol
created_by: dph
creation_date: 2015-07-08T13:42:15Z

[Term]
id: GO:0061726
name: mitochondrion disassembly
namespace: biological_process
def: "The disaggregation of a mitochondrion into its constituent components." [GOC:autophagy, PMID:25009776]
synonym: "mitochondrion degradation" EXACT [GOC:autophagy]
is_a: GO:1903008 ! organelle disassembly
created_by: dph
creation_date: 2015-07-08T13:59:16Z

[Term]
id: GO:0061727
name: methylglyoxal catabolic process to lactate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into lactate." [GOC:dph, PMID:2198020]
is_a: GO:0006089 ! lactate metabolic process
is_a: GO:0051596 ! methylglyoxal catabolic process
created_by: dph
creation_date: 2015-07-21T17:25:57Z

[Term]
id: GO:0061728
name: GDP-mannose biosynthetic process from mannose
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of GDP-mannose from mannose." [GOC:dph, PMID:16339137, PMID:24218558]
is_a: GO:0006013 ! mannose metabolic process
is_a: GO:0009298 ! GDP-mannose biosynthetic process
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:0044763 ! single-organism cellular process
created_by: dph
creation_date: 2015-07-24T14:44:04Z

[Term]
id: GO:0061729
name: GDP-mannose biosynthetic process from fructose-6-phosphate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of GDP-mannose from fructose-6-phosphate." [GOC:dph, PMID:16339137]
xref: Reactome:R-HSA-446205 "Synthesis of GDP-mannose, Homo sapiens"
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0009298 ! GDP-mannose biosynthetic process
is_a: GO:0019637 ! organophosphate metabolic process
created_by: dph
creation_date: 2015-07-24T14:50:44Z

[Term]
id: GO:0061730
name: C-rich strand telomeric DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with C-rich, single-stranded, telomere-associated DNA." [GOC:dph, GOC:kmv, PMID:18329362]
is_a: GO:0043047 ! single-stranded telomeric DNA binding
created_by: dph
creation_date: 2015-08-20T09:08:27Z

[Term]
id: GO:0061731
name: ribonucleoside-diphosphate reductase activity
namespace: molecular_function
def: "Catalysis of the formation of 2'-deoxyribonucleoside diphosphate from ribonucleoside diphosphate, using either thioredoxin disulfide or glutaredoxin disulfide as an acceptor." [GOC:dph, GOC:vw, PMID:16756507]
synonym: "adenosylcobalamin-dependent ribonucleotide reductase activity" RELATED []
synonym: "aerobic non-heme iron-dependent ribonucleotide reductase activity" RELATED []
synonym: "anaerobic iron-sulfur-dependent ribonucleotide reductase activity" RELATED []
synonym: "class I ribonucleotide reductase activity" RELATED []
synonym: "class II ribonucleoside-diphosphate reductase activity" RELATED []
synonym: "class II ribonucleotide reductase activity" RELATED []
synonym: "class III ribonucleotide reductase activity" RELATED []
synonym: "nucleoside diphosphate reductase activity" RELATED []
synonym: "purine/pyrimidine nucleoside diphosphate reduction" RELATED []
synonym: "ribonucleoside 5'-diphosphate reductase activity" EXACT []
synonym: "ribonucleotide diphosphate reductase activity" EXACT []
synonym: "ribonucleotide reductase activity" BROAD []
synonym: "RNR" RELATED []
is_a: GO:0016728 ! oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor
created_by: dph
creation_date: 2015-08-24T07:25:59Z

[Term]
id: GO:0061732
name: mitochondrial acetyl-CoA biosynthetic process from pyruvate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate in the mitochondrion. The process begins with the transport of pyruvate from the cytosol to the mitochondrion where it is subsequently decarboxylated to form acetyl-CoA." [GOC:dph, ISBN:0201090910]
xref: Reactome:R-HSA-372342.1
xref: Reactome:R-HSA-71397.1
is_a: GO:0006086 ! acetyl-CoA biosynthetic process from pyruvate
is_a: GO:0046496 ! nicotinamide nucleotide metabolic process
created_by: dph
creation_date: 2015-08-24T13:44:02Z

[Term]
id: GO:0061733
name: peptide-lysine-N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + lysine in peptide = CoA + N-acetyl-lysine-peptide." [GOC:dph]
is_a: GO:0034212 ! peptide N-acetyltransferase activity
created_by: dph
creation_date: 2015-09-10T10:22:19Z

[Term]
id: GO:0061734
name: parkin-mediated mitophagy in response to mitochondrial depolarization
namespace: biological_process
def: "The macromitophagy pathway that is triggered by mitochondrial depolarization and requires the function of a parkin-family molecule." [GOC:autophagy, GOC:dph, GOC:pad, GOC:PARL, PMID:25349190]
is_a: GO:0098779 ! mitophagy in response to mitochondrial depolarization
created_by: dph
creation_date: 2015-09-14T13:48:57Z

[Term]
id: GO:0061735
name: dynamin-like protein-mediated mitophagy in response to mitochondrial depolarization
namespace: biological_process
def: "The macromitophagy pathway that is triggered by mitochondrial depolarization and requires the function of a dynamin-like molecule." [GOC:autophagy, GOC:dph, GOC:pad, GOC:PARL, PMID:25349190]
is_a: GO:0098779 ! mitophagy in response to mitochondrial depolarization
created_by: dph
creation_date: 2015-09-14T14:00:43Z

[Term]
id: GO:0061736
name: engulfment of target by autophagosome
namespace: biological_process
def: "The membrane invagination process by which an autophagosomal membrane surrounds an object that will be degraded by macroautophagy." [GOC:autophagy, GOC:dph, GOC:pad, GOC:PARL]
is_a: GO:1902534 ! single-organism membrane invagination
intersection_of: GO:1902534 ! single-organism membrane invagination
intersection_of: part_of GO:0016236 ! macroautophagy
relationship: part_of GO:0016236 ! macroautophagy
created_by: dph
creation_date: 2015-09-14T14:10:24Z

[Term]
id: GO:0061737
name: leukotriene signaling pathway
namespace: biological_process
def: "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-leukotriene interaction and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:dph, PMID:21771892]
is_a: GO:0007186 ! G-protein coupled receptor signaling pathway
created_by: dph
creation_date: 2015-09-15T12:58:21Z

[Term]
id: GO:0061738
name: late endosomal microautophagy
namespace: biological_process
def: "The autophagy process by which cytosolic proteins targeted for degradation are tagged with a chaperone and are directly transferred into and degraded in a late endosomal compartment." [GOC:autophagy, GOC:dph, GOC:pad, GOC:PARL, PMID:21238931]
is_a: GO:0006914 ! autophagy
created_by: dph
creation_date: 2015-09-24T14:40:02Z

[Term]
id: GO:0061739
name: protein lipidation involved in autophagosome assembly
namespace: biological_process
def: "The protein lipidation process by which phosphatidylethanolamine is conjugated to a protein of the ATG8 family, leading to membrane insertion of the protein as a step in autophagosome assembly." [GOC:autophagy, GOC:dph, PMID:11096062, PMID:11100732, PMID:15277523]
is_a: GO:0006501 ! C-terminal protein lipidation
intersection_of: GO:0006501 ! C-terminal protein lipidation
intersection_of: part_of GO:0000045 ! autophagosome assembly
relationship: has_part GO:0019779 ! Atg8 activating enzyme activity
relationship: part_of GO:0000045 ! autophagosome assembly
created_by: dph
creation_date: 2015-10-14T12:02:01Z

[Term]
id: GO:0061740
name: protein targeting to lysosome involved in chaperone-mediated autophagy
namespace: biological_process
def: "The targeting of a protein to the lysosome process in which an input protein binds to a chaperone and subsequently to a lysosomal receptor." [GOC:dph, GOC:pad, GOC:PARL, PMID:22748206]
is_a: GO:0006622 ! protein targeting to lysosome
is_a: GO:0071211 ! protein targeting to vacuole involved in autophagy
intersection_of: GO:0006622 ! protein targeting to lysosome
intersection_of: part_of GO:0061684 ! chaperone-mediated autophagy
relationship: has_part GO:0005102 ! receptor binding
relationship: has_part GO:0051087 ! chaperone binding
relationship: part_of GO:0061684 ! chaperone-mediated autophagy
created_by: dph
creation_date: 2015-10-21T08:41:29Z

[Term]
id: GO:0061741
name: chaperone-mediated protein transport involved in chaperone-mediated autophagy
namespace: biological_process
def: "The chaperone-mediated protein transport process in which a protein that is bound to a chaperone and a lysosomal receptor is unfolded and transported into the lysosome as part of chaperone-mediated autophagy." [GOC:autophagy, GOC:dph, GOC:pad, GOC:PARL, PMID:22748206]
is_a: GO:0034486 ! vacuolar transmembrane transport
is_a: GO:0065002 ! intracellular protein transmembrane transport
is_a: GO:0072321 ! chaperone-mediated protein transport
intersection_of: GO:0072321 ! chaperone-mediated protein transport
intersection_of: part_of GO:0061684 ! chaperone-mediated autophagy
relationship: has_part GO:0043335 ! protein unfolding
relationship: part_of GO:0061684 ! chaperone-mediated autophagy
created_by: dph
creation_date: 2015-10-21T08:56:33Z

[Term]
id: GO:0061742
name: chaperone-mediated autophagy translocation complex
namespace: cellular_component
def: "A lysosomal membrane protein complex that enables the translocation of a target protein across the lysosomal membrane as part of chaperone-mediated autophagy." [GOC:dph, GOC:pad, GOC:PARL, PMID:20797626]
synonym: "chaperone-mediated autophagy receptor complex" RELATED [GOC:dph, GOC:pad, GOC:PARL]
synonym: "CMA receptor complex" RELATED [GOC:dph, GOC:pad, GOC:PARL]
synonym: "CMA translocation complex" EXACT [GOC:dph, GOC:pad, GOC:PARL, PMID:20797626]
is_a: GO:0044437 ! vacuolar part
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0005765 ! lysosomal membrane
created_by: dph
creation_date: 2015-10-23T07:39:04Z

[Term]
id: GO:0061743
name: motor learning
namespace: biological_process
def: "Any process in which an organism acquires a novel neuromuscular action or movement as the result of experience." [GOC:bf, GOC:PARL, Wikipedia:Motor_learning]
is_a: GO:0007612 ! learning
created_by: dph
creation_date: 2015-11-09T12:40:29Z

[Term]
id: GO:0061744
name: motor behavior
namespace: biological_process
def: "The specific neuromuscular movement of a single organism in response to external or internal stimuli." [GOC:bf, GOC:PARL, PMID:25318560]
is_a: GO:0044708 ! single-organism behavior
created_by: dph
creation_date: 2015-11-09T12:43:11Z

[Term]
id: GO:0061745
name: GTPase activity, coupled
namespace: molecular_function
def: "Catalysis of the reaction: GTP + H2O = GDP + phosphate; this reaction directly drives some other reaction." [GOC:dph, PMID:26277776]
is_a: GO:0003924 ! GTPase activity
created_by: dph
creation_date: 2015-11-11T12:47:56Z

[Term]
id: GO:0061746
name: single-stranded DNA-dependent GTPase activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP + H2O = GDP + phosphate; this reaction requires the presence of single-stranded DNA, and it drives another reaction." [GOC:dph, PMID:26277776]
is_a: GO:0061745 ! GTPase activity, coupled
created_by: dph
creation_date: 2015-11-11T12:50:19Z

[Term]
id: GO:0061747
name: CTPase activity, coupled
namespace: molecular_function
def: "Catalysis of the reaction: CTP + H2O = CDP + phosphate; this reaction directly drives some other reaction." [GOC:dph, PMID:26277776]
is_a: GO:0043273 ! CTPase activity
created_by: dph
creation_date: 2015-11-11T13:02:49Z

[Term]
id: GO:0061748
name: single-stranded DNA-dependent CTPase activity
namespace: molecular_function
def: "Catalysis of the reaction: CTP + H2O = CDP + phosphate; this reaction requires the presence of single-stranded DNA, and it drives another reaction." [GOC:dph, PMID:26277776]
is_a: GO:0061747 ! CTPase activity, coupled
created_by: dph
creation_date: 2015-11-11T13:05:32Z

[Term]
id: GO:0061749
name: forked DNA-dependent helicase activity
namespace: molecular_function
def: "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix containing forked DNA." [GOC:dph, PMID:26277776]
is_a: GO:0003678 ! DNA helicase activity
created_by: dph
creation_date: 2015-11-11T13:10:51Z

[Term]
id: GO:0061750
name: acid sphingomyelin phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+) in an acidic environment." [GOC:dph, PMID:26493087]
synonym: "acid SMase" RELATED [PMID:26493087]
synonym: "acid sphingomyelinase" EXACT [PMID:26493087]
is_a: GO:0004767 ! sphingomyelin phosphodiesterase activity
created_by: dph
creation_date: 2015-11-11T14:47:45Z

[Term]
id: GO:0061751
name: neutral sphingomyelin phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+) in a neutral environment." [GOC:dph, PMID:26493087]
synonym: "neutral SMase" EXACT [PMID:26493087]
synonym: "neutral sphingomyelinase" EXACT [GOC:26493087]
is_a: GO:0004767 ! sphingomyelin phosphodiesterase activity
created_by: dph
creation_date: 2015-11-11T14:48:08Z

[Term]
id: GO:0061752
name: telomeric repeat-containing RNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with long non-coding RNA molecules transcribed from subtelomeric regions in most eukaryotes. Telomeric repeat-containing RNA (TERRA) molecules consist of subtelomeric-derived sequences and G-rich telomeric repeats." [GOC:BHF, GOC:BHF_telomere, GOC:dph, GOC:jbu, PMID:20655916]
synonym: "TERRA binding" EXACT [PMID:20655916]
is_a: GO:0003723 ! RNA binding
created_by: dph
creation_date: 2015-11-13T07:55:06Z

[Term]
id: GO:0061753
name: substrate localization to autophagosome
namespace: biological_process
def: "The localization process by which an autophagic substrate is delivered to a forming autophagosome." [GOC:dph, GOC:pad, GOC:PARL, PMID:23545414]
synonym: "substrate sequestration to autophagosome" EXACT []
synonym: "substrate sequestration to phagophore" EXACT []
is_a: GO:0051649 ! establishment of localization in cell
created_by: dph
creation_date: 2015-11-20T11:14:22Z

[Term]
id: GO:0061754
name: negative regulation of circulating fibrinogen levels
namespace: biological_process
def: "Any process that reduces the quantity of fibrinogen circulating in the bloodstream." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:20570858]
is_a: GO:0044537 ! regulation of circulating fibrinogen levels
created_by: dph
creation_date: 2016-02-29T16:19:09Z

[Term]
id: GO:0061755
name: positive regulation of circulating fibrinogen levels
namespace: biological_process
def: "Any process that increases the quantity of fibrinogen circulating in the bloodstream." [GOC:bf, GOC:BHF, GOC:BHF_miRNA, PMID:20570858]
is_a: GO:0044537 ! regulation of circulating fibrinogen levels
created_by: dph
creation_date: 2016-02-29T16:26:49Z

[Term]
id: GO:0061756
name: leukocyte adhesion to vascular endothelial cell
namespace: biological_process
def: "The attachment of a leukocyte to vascular endothelial cell via adhesion molecules." [GOC:add, GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:23897866]
is_a: GO:0007159 ! leukocyte cell-cell adhesion
created_by: dph
creation_date: 2016-02-29T16:42:11Z

[Term]
id: GO:0061757
name: leukocyte adhesion to arterial endothelial cell
namespace: biological_process
def: "The attachment of a leukocyte to an arterial endothelial cell via adhesion molecules." [GOC:add, GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:22267480]
is_a: GO:0061756 ! leukocyte adhesion to vascular endothelial cell
created_by: dph
creation_date: 2016-02-29T16:49:38Z

[Term]
id: GO:0061758
name: 2-hydroxyglutarate dehydrogenase activity, forward reaction
namespace: molecular_function
def: "Catalysis of the reaction: (S)-2-hydroxyglutarate + acceptor -> 2-oxoglutarate + reduced acceptor." [EC:1.1.99.2, GOC:dph, MetaCyc:2-HYDROXYGLUTARATE-DEHYDROGENASE-RXN]
synonym: "alpha-ketoglutarate reductase activity, reverse reaction" EXACT [GOC:dph]
xref: Reactome:REACT_24926 "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2, Homo sapiens"
xref: RHEA:21253
is_a: GO:0047545 ! 2-hydroxyglutarate dehydrogenase activity
created_by: dph
creation_date: 2016-03-07T08:28:58Z

[Term]
id: GO:0061759
name: alpha-ketoglutarate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + reduced acceptor -> (S)-2-hydroxyglutarate + acceptor." [EC:1.1.99.2, GOC:dph, PMID:26774271]
synonym: "2-hydroxyglutarate dehydrogenase activity, reverse reaction" EXACT [GOC:dph]
synonym: "2-ketoglutarate reductase activity" RELATED [GOC:dph]
synonym: "2-oxoglutarate reductase activity" RELATED [GOC:dph]
synonym: "D-2HG reductase activity" RELATED [GOC:dph]
xref: RHEA:21254
is_a: GO:0047545 ! 2-hydroxyglutarate dehydrogenase activity
created_by: dph
creation_date: 2016-03-07T08:38:57Z

[Term]
id: GO:0061760
name: antifungal innate immune response
namespace: biological_process
def: "An defense response against a fungus mediated through an innate immune response. An innate immune response is mediated by germline encoded components that directly recognize components of potential pathogens." [GOC:dph, PMID:22470487]
is_a: GO:0045087 ! innate immune response
is_a: GO:0050832 ! defense response to fungus
created_by: dph
creation_date: 2016-03-07T08:53:08Z

[Term]
id: GO:0061761
name: alpha-latrotoxin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an alpha-latrotoxin receptor." [GOC:dph, PMID:21724987]
synonym: "lasso receptor binding" EXACT [GOC:dph, PMID:21724987]
synonym: "latrophilin binding" EXACT [GOC:dph, PMID:21724987]
is_a: GO:0001664 ! G-protein coupled receptor binding
created_by: dph
creation_date: 2016-04-13T10:46:42Z

[Term]
id: GO:0061762
name: CAMKK-AMPK signaling cascade
namespace: biological_process
def: "A series of molecular signals in which calmodulin-dependent protein kinase activity enabled by a CAMKK directly activates an AMPK. The cascade begins with calmodulin binding calcium which in turn binds CAMKK enabling its calmodulin-dependent protein kinase activity. The cascade ends with AMP-activated protein kinase activity." [GOC:dph, GOC:pad, GOC:PARL, PMID:23010169, PMID:24709372]
synonym: "stress-activated AMP-activated protein kinase signaling cascade" RELATED [GOC:dph]
is_a: GO:0019722 ! calcium-mediated signaling
relationship: has_part GO:0004683 ! calmodulin-dependent protein kinase activity
relationship: has_part GO:0005516 ! calmodulin binding
created_by: dph
creation_date: 2016-04-14T12:59:31Z

[Term]
id: GO:0061763
name: multivesicular body-lysosome fusion
namespace: biological_process
def: "The organelle membrane fusion process in which the membrane of a multivesicular body fuses with a lysosome to create a hybrid organelle." [GOC:dph, GOC:pad, GOC:PARL, PMID:21118109]
synonym: "fusion of multivesicular body to lysosome" EXACT [GOC:dph]
synonym: "fusion of MVB to lysosome" EXACT [GOC:dph]
synonym: "MVB-lysosome fusion" EXACT [GOC:dph]
is_a: GO:0090174 ! organelle membrane fusion
is_a: GO:0097576 ! vacuole fusion
relationship: part_of GO:0032510 ! endosome to lysosome transport via multivesicular body sorting pathway
created_by: dph
creation_date: 2016-04-15T07:12:40Z

[Term]
id: GO:0061764
name: late endosome to lysosome transport via multivesicular body sorting pathway
namespace: biological_process
def: "The directed movement of substances from late endosomes to lysosomes by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the lysosome." [GOC:dph]
is_a: GO:0032510 ! endosome to lysosome transport via multivesicular body sorting pathway
is_a: GO:1902774 ! late endosome to lysosome transport
created_by: dph
creation_date: 2016-04-19T09:29:57Z

[Term]
id: GO:0061765
name: modulation by virus of host NIK/NF-kappaB signaling
namespace: biological_process
def: "Any process in which a virus effect a change in the frequency, rate or extent of NIK/NF-kappaB signaling in the host." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:26764146]
is_a: GO:0019054 ! modulation by virus of host process
is_a: GO:1901222 ! regulation of NIK/NF-kappaB signaling
created_by: dph
creation_date: 2016-04-19T10:41:22Z

[Term]
id: GO:0061766
name: positive regulation of lung blood pressure
namespace: biological_process
def: "The process that increases the force with which blood travels through the lungs." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:22161164]
synonym: "positive regulation of pulmonary blood pressure" EXACT [GOC:dph]
is_a: GO:0014916 ! regulation of lung blood pressure
created_by: dph
creation_date: 2016-04-27T11:54:34Z

[Term]
id: GO:0061767
name: negative regulation of lung blood pressure
namespace: biological_process
def: "The process that decreases the force with which blood travels through the lungs." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:dph, PMID:22161164]
synonym: "negative regulation of pulmonary blood pressure" EXACT [GOC:dph]
is_a: GO:0014916 ! regulation of lung blood pressure
created_by: dph
creation_date: 2016-04-27T11:58:55Z

[Term]
id: GO:0065001
name: specification of axis polarity
namespace: biological_process
def: "The pattern specification process in which the polarity of a body or organ axis is established and maintained." [GOC:mah]
is_a: GO:0007389 ! pattern specification process
relationship: part_of GO:0009798 ! axis specification

[Term]
id: GO:0065002
name: intracellular protein transmembrane transport
namespace: biological_process
def: "The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore." [GOC:isa_complete]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "intracellular membrane translocation of a protein" EXACT []
synonym: "intracellular protein membrane transport" EXACT []
synonym: "intracellular protein transport across a membrane" EXACT []
is_a: GO:0006886 ! intracellular protein transport
is_a: GO:0071806 ! protein transmembrane transport
is_a: GO:1902582 ! single-organism intracellular transport
intersection_of: GO:0071806 ! protein transmembrane transport
intersection_of: occurs_in GO:0005622 ! intracellular
relationship: occurs_in GO:0005622 ! intracellular

[Term]
id: GO:0065003
name: macromolecular complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of macromolecules to form a complex." [GOC:jl]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_pir
subset: gosubset_prok
synonym: "macromolecule complex assembly" EXACT []
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0043933 ! macromolecular complex subunit organization

[Term]
id: GO:0065004
name: protein-DNA complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex." [GOC:jl]
subset: gosubset_prok
synonym: "DNA-protein complex assembly" EXACT [GOC:mah]
is_a: GO:0034622 ! cellular macromolecular complex assembly
is_a: GO:0071824 ! protein-DNA complex subunit organization

[Term]
id: GO:0065005
name: protein-lipid complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins and lipids to form a protein-lipid complex." [GOC:jl]
subset: gosubset_prok
is_a: GO:0065003 ! macromolecular complex assembly
is_a: GO:0071825 ! protein-lipid complex subunit organization

[Term]
id: GO:0065006
name: protein-carbohydrate complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins and carbohydrates to form a protein-carbohydrate complex." [GOC:jl]
subset: gosubset_prok
is_a: GO:0065003 ! macromolecular complex assembly
is_a: GO:0071823 ! protein-carbohydrate complex subunit organization

[Term]
id: GO:0065007
name: biological regulation
namespace: biological_process
def: "Any process that modulates a measurable attribute of any biological process, quality or function." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]
subset: goslim_pir
subset: gosubset_prok
synonym: "regulation" BROAD []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0065008
name: regulation of biological quality
namespace: biological_process
def: "Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]
subset: gosubset_prok
synonym: "regulation of biological attribute" EXACT []
synonym: "regulation of biological characteristic" EXACT []
is_a: GO:0065007 ! biological regulation

[Term]
id: GO:0065009
name: regulation of molecular function
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GOC:isa_complete]
subset: gosubset_prok
synonym: "regulation of a molecular function" EXACT []
is_a: GO:0065007 ! biological regulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003674 ! molecular_function
relationship: regulates GO:0003674 ! molecular_function

[Term]
id: GO:0065010
name: extracellular membrane-bounded organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete]
synonym: "extracellular membrane-enclosed organelle" EXACT []
is_a: GO:0043227 ! membrane-bounded organelle
is_a: GO:0043230 ! extracellular organelle

[Term]
id: GO:0070001
name: aspartic-type peptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides

[Term]
id: GO:0070002
name: glutamic-type peptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides

[Term]
id: GO:0070003
name: threonine-type peptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides

[Term]
id: GO:0070004
name: cysteine-type exopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of C- or N-terminal peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#EXOPEPTIDASE]
is_a: GO:0008234 ! cysteine-type peptidase activity
is_a: GO:0008238 ! exopeptidase activity

[Term]
id: GO:0070005
name: cysteine-type aminopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of N-terminal peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#AMINOPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
xref: EC:3.4.18
is_a: GO:0004177 ! aminopeptidase activity
is_a: GO:0070004 ! cysteine-type exopeptidase activity

[Term]
id: GO:0070006
name: metalloaminopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of N-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#AMINOPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
is_a: GO:0004177 ! aminopeptidase activity
is_a: GO:0008235 ! metalloexopeptidase activity

[Term]
id: GO:0070007
name: glutamic-type endopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
is_a: GO:0004175 ! endopeptidase activity
is_a: GO:0070002 ! glutamic-type peptidase activity

[Term]
id: GO:0070008
name: serine-type exopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#EXOPEPTIDASE, ISBN:0716720094]
subset: gosubset_prok
xref: EC:3.4.21
is_a: GO:0008236 ! serine-type peptidase activity
is_a: GO:0008238 ! exopeptidase activity

[Term]
id: GO:0070009
name: serine-type aminopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a peptide bond not more than three residues from the N-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#AMINOPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
is_a: GO:0004177 ! aminopeptidase activity
is_a: GO:0070008 ! serine-type exopeptidase activity

[Term]
id: GO:0070010
name: peptidase activity, acting on D-amino acid peptides
namespace: molecular_function
def: "Catalysis of the hydrolysis of peptide bonds formed between D-amino acids." [GOC:mah]
is_a: GO:0008233 ! peptidase activity

[Term]
id: GO:0070011
name: peptidase activity, acting on L-amino acid peptides
namespace: molecular_function
def: "Catalysis of the hydrolysis of peptide bonds formed between L-amino acids." [GOC:mah]
subset: gosubset_prok
is_a: GO:0008233 ! peptidase activity

[Term]
id: GO:0070012
name: oligopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a peptide bond in an oligopeptide, i.e. a molecule containing a small number (2 to 20) of amino acid residues connected by peptide bonds." [GOC:mah, ISBN:0198506732]
is_a: GO:0008233 ! peptidase activity

[Term]
id: GO:0070013
name: intracellular organelle lumen
namespace: cellular_component
def: "An organelle lumen that is part of an intracellular organelle." [GOC:mah]
is_a: GO:0043233 ! organelle lumen
is_a: GO:0044446 ! intracellular organelle part

[Term]
id: GO:0070014
name: sucrase-isomaltase complex
namespace: cellular_component
def: "A protein complex that possesses oligo-1,6-glucosidase activity; the complex is a heterodimer located in the cell membrane, and is formed by proteolytic cleavage of a single precursor polypeptide. The two subunits have different substrate specificities." [PMID:3366777]
synonym: "oligo-1,6-glucosidase complex" RELATED []
xref: Wikipedia:Sucrase-isomaltase
is_a: GO:0098797 ! plasma membrane protein complex
is_a: GO:1902687 ! glucosidase complex
relationship: part_of GO:0005887 ! integral component of plasma membrane

[Term]
id: GO:0070016
name: armadillo repeat domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the armadillo repeat domain of a protein, an approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity protein armadillo. Arm-repeat proteins are involved in various processes, including intracellular signalling and cytoskeletal regulation." [GOC:BHF, GOC:mah, GOC:vk, InterPro:IPR000225]
synonym: "Arm repeat domain binding" EXACT []
synonym: "armadillo domain binding" EXACT []
synonym: "armadillo repeat binding" EXACT []
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0070017
name: alphav-beta3 integrin-thrombospondin complex
namespace: cellular_component
def: "A protein complex that consists of an alphav-beta3 integrin complex bound to thrombospondin." [PMID:2478219]
synonym: "ITGAV-ITGB3-THBS1 complex" NARROW [CORUM:2846]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070018
name: transforming growth factor beta type I receptor homodimeric complex
namespace: cellular_component
def: "A receptor complex that consists of two transforming growth factor beta (TGF-beta) type I receptor monomers. TGF-beta type I receptor dimers form in the presence or absence of ligand, and can associate with ligand-bound TGF-beta type II receptor dimers." [Reactome:REACT_7737]
synonym: "TGF-beta type I receptor complex" EXACT []
synonym: "TGF-beta type I receptor dimer" EXACT [Reactome:REACT_7737]
synonym: "TGFBR1 homodimer" EXACT [Reactome:REACT_7737]
synonym: "transforming growth factor beta type I receptor complex" EXACT [GOC:bf]
is_a: GO:0070022 ! transforming growth factor beta receptor homodimeric complex

[Term]
id: GO:0070019
name: transforming growth factor beta type II receptor homodimeric complex
namespace: cellular_component
def: "A receptor complex that consists of two transforming growth factor beta (TGF-beta) type II receptor monomers. TGF-beta type II receptor dimers form in the presence or absence of ligand, and upon ligand binding can associate with TGF-beta type I receptor dimers." [Reactome:REACT_7415]
synonym: "TGF-beta type II receptor complex" EXACT []
synonym: "TGF-beta type II receptor dimer" EXACT [Reactome:REACT_7415]
synonym: "TGFBR2 homodimer" EXACT [Reactome:REACT_7415]
synonym: "transforming growth factor beta type II receptor complex" EXACT [GOC:bf]
is_a: GO:0070022 ! transforming growth factor beta receptor homodimeric complex

[Term]
id: GO:0070020
name: transforming growth factor beta1-type II receptor complex
namespace: cellular_component
def: "A protein complex that consists of a dimeric transforming growth factor beta (TGF-beta) type II receptor bound to a TGF-beta1 dimer." [Reactome:REACT_7218]
subset: goslim_pir
synonym: "TGF-beta receptor II-TGF-beta1 complex" EXACT []
synonym: "TGF-beta1-type II receptor complex" EXACT [Reactome:REACT_7218]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070021
name: transforming growth factor beta1-type II receptor-type I receptor complex
namespace: cellular_component
def: "A protein complex that is formed by the association of a ligand-bound TGF-beta type II receptor dimer with a TGF-beta type I receptor dimer." [Reactome:REACT_7425]
subset: goslim_pir
synonym: "TGF-beta 1:type II receptor:type I receptor complex" EXACT [Reactome:REACT_7425]
synonym: "TGF-beta receptor II-TGF-beta receptor I-TGF-beta1 complex" EXACT []
synonym: "TGF-beta1-type II receptor-type I receptor complex" EXACT []
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070022
name: transforming growth factor beta receptor homodimeric complex
namespace: cellular_component
def: "A homodimeric receptor complex that consists of two TGF-beta receptor monomers." [GOC:mah, Reactome:REACT_7415, Reactome:REACT_7737]
synonym: "TGF-beta receptor complex" BROAD []
synonym: "transforming growth factor beta receptor complex" EXACT [GOC:bf]
is_a: GO:0098802 ! plasma membrane receptor complex
is_a: GO:1902554 ! serine/threonine protein kinase complex
relationship: part_of GO:0005887 ! integral component of plasma membrane

[Term]
id: GO:0070023
name: interleukin-12-interleukin-12 receptor complex
namespace: cellular_component
def: "A protein complex that is formed by the association of a heterodimeric interleukin-12 receptor complex with an interleukin-12 heterodimer." [PMID:11900991]
subset: goslim_pir
synonym: "IL12-IL12 receptor complex" EXACT []
synonym: "IL12B-IL12RB1-IL12RB2 complex" NARROW [CORUM:2020]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070024
name: CD19-Vav-PIK3R1 complex
namespace: cellular_component
def: "A protein complex that contains the cell surface signaling molecule CD19, the Ras guanine nucleotide exchange factor Vav, and the regulatory subunit alpha of phosphatidylinositol 3-kinase (PI3K)." [PMID:7528218]
subset: goslim_pir
synonym: "CD19-Vav-PI 3-kinase (p85 subunit) complex" EXACT [CORUM:2574]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070025
name: carbon monoxide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with carbon monoxide (CO)." [GOC:ecd]
subset: gosubset_prok
synonym: "CO binding" EXACT []
is_a: GO:0043169 ! cation binding

[Term]
id: GO:0070026
name: nitric oxide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with nitric oxide (NO)." [GOC:ecd]
subset: gosubset_prok
synonym: "nitrogen monoxide binding" EXACT []
synonym: "nitrosyl binding" EXACT [CHEBI:16480]
synonym: "NO binding" EXACT []
is_a: GO:0005488 ! binding

[Term]
id: GO:0070027
name: carbon monoxide sensor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with and responding, e.g. by conformational change, to changes in the cellular level of carbon monoxide (CO)." [GOC:ecd]
is_a: GO:0070025 ! carbon monoxide binding

[Term]
id: GO:0070028
name: regulation of transcription by carbon monoxide
namespace: biological_process
def: "Any process involving carbon monoxide that modulates the frequency, rate or extent of transcription." [GOC:ecd]
subset: gosubset_prok
synonym: "regulation of transcription by CO" EXACT []
is_a: GO:0006355 ! regulation of transcription, DNA-templated
relationship: part_of GO:0071245 ! cellular response to carbon monoxide

[Term]
id: GO:0070029
name: alphav-beta3 integrin-osteopontin complex
namespace: cellular_component
def: "A protein complex that consists of an alphav-beta3 integrin complex bound to osteopontin." [PMID:7532190]
synonym: "ITGAV-ITGB3-SPP1 complex" NARROW [CORUM:2358]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070030
name: alphav-beta1 integrin-osteopontin complex
namespace: cellular_component
def: "A protein complex that consists of an alphav-beta1 integrin complex bound to osteopontin." [PMID:7592829]
synonym: "ITGAV-ITGB1-SPP1 complex" NARROW [CORUM:2885]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070031
name: alphav-beta5 integrin-osteopontin complex
namespace: cellular_component
def: "A protein complex that consists of an alphav-beta5 integrin complex bound to osteopontin." [PMID:7592829]
synonym: "ITGAV-ITGB5-SPP1 complex" NARROW [CORUM:2347]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070032
name: synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
namespace: cellular_component
def: "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, and complexin I (or orthologs thereof)." [PMID:7553862]
synonym: "SNARE complex (Vamp2, Snap25, Stx1a, Cplx1)" NARROW [CORUM:795]
synonym: "Vamp2-Snap25-Stx1a-Cplx1 complex" NARROW [CORUM:795]
is_a: GO:0031201 ! SNARE complex

[Term]
id: GO:0070033
name: synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex
namespace: cellular_component
def: "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, and complexin II (or orthologs thereof)." [PMID:7553862]
synonym: "SNARE complex (Vamp2, Snap25, Stx1a, Cplx2)" NARROW [CORUM:796]
synonym: "Vamp2-Snap25-Stx1a-Cplx2 complex" NARROW [CORUM:796]
is_a: GO:0031201 ! SNARE complex

[Term]
id: GO:0070034
name: telomerase RNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the telomerase RNA template." [GOC:krc, PMID:16884717]
synonym: "TERC binding" RELATED [GOC:dph]
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0070035
name: purine NTP-dependent helicase activity
namespace: molecular_function
def: "Catalysis of the reaction: purine NTP + H2O = purine NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah]
subset: gosubset_prok
is_a: GO:0004386 ! helicase activity

[Term]
id: GO:0070036
name: GTP-dependent helicase activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP + H2O = GDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah]
subset: gosubset_prok
is_a: GO:0061745 ! GTPase activity, coupled
is_a: GO:0070035 ! purine NTP-dependent helicase activity

[Term]
id: GO:0070037
name: rRNA (pseudouridine) methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a pseudouridine residue in an rRNA molecule." [GOC:imk, GOC:mah]
subset: gosubset_prok
is_a: GO:0008649 ! rRNA methyltransferase activity

[Term]
id: GO:0070038
name: rRNA (pseudouridine-N3-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N3-methylpseudouridine." [GOC:imk, GOC:mah]
subset: gosubset_prok
is_a: GO:0070037 ! rRNA (pseudouridine) methyltransferase activity

[Term]
id: GO:0070039
name: rRNA (guanosine-2'-O-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methylguanosine." [GOC:imk, GOC:mah]
subset: gosubset_prok
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0016435 ! rRNA (guanine) methyltransferase activity
relationship: part_of GO:0000451 ! rRNA 2'-O-methylation

[Term]
id: GO:0070040
name: rRNA (adenine-C2-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + adenine(2503) in 23S rRNA = S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + rRNA containing C2-methyladenine(2503) in 23S rRNA." [GOC:imk, PMID:20007606, PMID:20184321, PMID:21368151, PMID:21415317, PMID:21527678]
subset: gosubset_prok
xref: EC:2.1.1.192
xref: MetaCyc:RXN-11586
is_a: GO:0008169 ! C-methyltransferase activity
is_a: GO:0016433 ! rRNA (adenine) methyltransferase activity

[Term]
id: GO:0070041
name: rRNA (uridine-C5-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing C5-methyluridine." [GOC:imk, GOC:mah]
subset: gosubset_prok
is_a: GO:0008169 ! C-methyltransferase activity
is_a: GO:0016436 ! rRNA (uridine) methyltransferase activity

[Term]
id: GO:0070042
name: rRNA (uridine-N3-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N3-methyluridine." [GOC:imk, GOC:mah]
subset: gosubset_prok
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0016436 ! rRNA (uridine) methyltransferase activity

[Term]
id: GO:0070043
name: rRNA (guanine-N7-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N7-methylguanine." [GOC:imk, GOC:mah]
subset: gosubset_prok
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0016435 ! rRNA (guanine) methyltransferase activity
relationship: part_of GO:0070476 ! rRNA (guanine-N7)-methylation

[Term]
id: GO:0070044
name: synaptobrevin 2-SNAP-25-syntaxin-1a complex
namespace: cellular_component
def: "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 1a (or orthologs thereof)." [PMID:10336434]
synonym: "Snap25-Stx1a-Vamp2 complex" NARROW []
synonym: "SNARE complex (Snap25, Stx1a, Vamp2)" NARROW [CORUM:998]
synonym: "SNARE complex (Stx1a, SNAP25, VAMP)" NARROW [CORUM:841]
synonym: "Stx1a-SNAP25-VAMP complex" NARROW [CORUM:841]
is_a: GO:0031201 ! SNARE complex

[Term]
id: GO:0070045
name: synaptobrevin 2-SNAP-25-syntaxin-2 complex
namespace: cellular_component
def: "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 2 (or orthologs thereof)." [PMID:10336434]
synonym: "SNARE complex (Stx2, Snap25, Vamp2)" NARROW [CORUM:851]
synonym: "Stx2-Snap25-Vamp2 complex" NARROW [CORUM:851]
is_a: GO:0031201 ! SNARE complex

[Term]
id: GO:0070046
name: synaptobrevin 2-SNAP-25-syntaxin-3 complex
namespace: cellular_component
def: "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 3 (or orthologs thereof)." [PMID:10336434]
synonym: "SNARE complex (Stx3, Snap25, Vamp2)" NARROW [CORUM:852]
synonym: "Stx3-Snap25-Vamp2 complex" NARROW [CORUM:852]
is_a: GO:0031201 ! SNARE complex

[Term]
id: GO:0070047
name: synaptobrevin 2-SNAP-25-syntaxin-4 complex
namespace: cellular_component
def: "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 4 (or orthologs thereof)." [PMID:10336434]
synonym: "SNARE complex (Stx4, Snap25, Vamp2)" NARROW [CORUM:853]
synonym: "Stx4-Snap25-Vamp2 complex" NARROW [CORUM:853]
is_a: GO:0031201 ! SNARE complex

[Term]
id: GO:0070048
name: endobrevin-SNAP-25-syntaxin-1a complex
namespace: cellular_component
def: "A SNARE complex that contains endobrevin (VAMP8), SNAP-25, and syntaxin 1a (or orthologs thereof)." [PMID:10336434]
synonym: "SNARE complex (Stx1a, Snap25, Vamp8)" NARROW [CORUM:854]
synonym: "Stx1a-Snap25-Vamp8 complex" NARROW [CORUM:854]
is_a: GO:0031201 ! SNARE complex

[Term]
id: GO:0070049
name: endobrevin-SNAP-25-syntaxin-2 complex
namespace: cellular_component
def: "A SNARE complex that contains endobrevin (VAMP8), SNAP-25, and syntaxin 2 (or orthologs thereof)." [PMID:10336434]
synonym: "SNARE complex (Stx2, Snap25, Vamp8)" NARROW [CORUM:855]
synonym: "Stx2-Snap25-Vamp8 complex" NARROW [CORUM:855]
is_a: GO:0031201 ! SNARE complex

[Term]
id: GO:0070050
name: neuron cellular homeostasis
namespace: biological_process
def: "The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state." [GOC:BHF, GOC:mah]
synonym: "neuron maintenance" EXACT []
is_a: GO:0019725 ! cellular homeostasis
is_a: GO:0060249 ! anatomical structure homeostasis

[Term]
id: GO:0070051
name: fibrinogen binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with fibrinogen, a highly soluble hexameric glycoprotein complex that is found in blood plasma and is converted to fibrin by thrombin in the coagulation cascade." [GOC:BHF, GOC:mah, GOC:vk]
is_a: GO:0032403 ! protein complex binding

[Term]
id: GO:0070052
name: collagen V binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type V collagen trimer." [GOC:BHF, GOC:mah]
is_a: GO:0005518 ! collagen binding

[Term]
id: GO:0070053
name: thrombospondin receptor activity
namespace: molecular_function
def: "Combining with thrombospondin and transmitting the signal to initiate a change in cell activity." [GOC:BHF, GOC:signaling, GOC:vk]
is_a: GO:0038023 ! signaling receptor activity

[Term]
id: GO:0070054
name: mRNA splicing, via endonucleolytic cleavage and ligation
namespace: biological_process
alt_id: GO:0061012
def: "Splicing of mRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons." [GOC:krc, GOC:mah]
comment: Note that while typically associated with tRNA splicing, splicing via endonucleolytic cleavages and subsequent ligation of the free exon ends is known to be used for some non-tRNA substrates, e.g. HAC1 (YFL031W) in S. cerevisiae and an intron in the 23S rRNA of the Archaeal species Desulfurococcus mobilis.
subset: gosubset_prok
synonym: "cytosolic mRNA splicing" RELATED [GOC:curators]
is_a: GO:0000394 ! RNA splicing, via endonucleolytic cleavage and ligation
is_a: GO:0006397 ! mRNA processing

[Term]
id: GO:0070055
name: mRNA endonucleolytic cleavage involved in unfolded protein response
namespace: biological_process
def: "The endonucleolytic cleavage of a mRNA containing an HAC1-type intron at the 5' and 3' splice sites. The cleavage step is part of unconventional mRNA splicing, and contributes to the endoplasmic reticulum unfolded protein response." [GOC:bf, GOC:krc, GOC:mah, PMID:10357823]
subset: gosubset_prok
synonym: "ERN1-mediated XBP-1 mRNA cleavage" RELATED [HGNC:3449]
synonym: "HAC1 mRNA cleavage" NARROW [GOC:bf]
synonym: "HAC1-type intron splice site recognition and cleavage" NARROW []
synonym: "IRE1-mediated XBP-1 mRNA cleavage" NARROW [GOC:bf]
synonym: "XBP1 mRNA cleavage" NARROW [GOC:bf]
is_a: GO:0098787 ! mRNA cleavage involved in mRNA processing
relationship: part_of GO:0030969 ! mRNA splicing via endonucleolytic cleavage and ligation involved in unfolded protein response

[Term]
id: GO:0070056
name: prospore membrane leading edge
namespace: cellular_component
def: "The region of the prospore membrane that extends to surround the spore nucleus; coated with specific proteins that are thought to play a role in prospore membrane organization." [GOC:mah, PMID:14702385]
synonym: "forespore membrane leading edge" EXACT []
is_a: GO:0044464 ! cell part
is_a: GO:0098589 ! membrane region
relationship: part_of GO:0005628 ! prospore membrane

[Term]
id: GO:0070057
name: prospore membrane spindle pole body attachment site
namespace: cellular_component
def: "The region of the prospore membrane to which the spindle pole body (SPB) is anchored; the prospore membrane extends from the SPB attachment site to surround the spore nucleus." [GOC:mah, PMID:14702385]
synonym: "forespore membrane SPB attachment site" EXACT []
synonym: "forespore membrane spindle pole body attachment site" EXACT []
synonym: "prospore membrane SPB attachment site" EXACT []
is_a: GO:0044464 ! cell part
is_a: GO:0098589 ! membrane region
relationship: part_of GO:0005628 ! prospore membrane

[Term]
id: GO:0070058
name: tRNA gene clustering
namespace: biological_process
def: "The process in which tRNA genes, which are not linearly connected on the chromosome, are transported in three dimensions to, and maintained together in, the nucleolus. This clustered positioning leads to transcriptional silencing of nearby RNA polymerase II promoters (termed tRNA gene mediated (tgm) silencing) in S. cerevisiae." [GOC:jh, GOC:mah, PMID:18708579]
is_a: GO:0051276 ! chromosome organization
is_a: GO:1902580 ! single-organism cellular localization
is_a: GO:1902589 ! single-organism organelle organization

[Term]
id: GO:0070059
name: intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
namespace: biological_process
def: "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:mah, GOC:mtg_apoptosis, PMID:18701708]
synonym: "apoptosis in response to endoplasmic reticulum stress" BROAD []
synonym: "apoptosis in response to ER stress" EXACT []
synonym: "apoptosis triggered by ER stress" EXACT []
synonym: "endoplasmic reticulum stress-induced apoptosis" EXACT []
synonym: "ER stress-induced apoptosis" EXACT []
synonym: "intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress" EXACT []
is_a: GO:0034976 ! response to endoplasmic reticulum stress
is_a: GO:0097193 ! intrinsic apoptotic signaling pathway

[Term]
id: GO:0070060
name: 'de novo' actin filament nucleation
namespace: biological_process
def: "The actin nucleation process in which actin monomers combine in the absence of any existing actin filaments; elongation of the actin oligomer formed by nucleation leads to the formation of an unbranched filament." [GOC:mah, PMID:17477841]
synonym: "formin-mediated actin filament nucleation" NARROW []
synonym: "unbranched actin filament nucleation" RELATED []
is_a: GO:0045010 ! actin nucleation

[Term]
id: GO:0070061
name: fructose binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the D- or L-enantiomer of fructose, the ketohexose arabino-hex-2-ulose." [CHEBI:28757, GOC:BHF, GOC:mah]
subset: gosubset_prok
is_a: GO:0048029 ! monosaccharide binding

[Term]
id: GO:0070062
name: extracellular exosome
namespace: cellular_component
def: "A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]
synonym: "exosome" EXACT [GOC:pr]
synonym: "extracellular vesicular exosome" EXACT [GOC:vesicles]
is_a: GO:1903561 ! extracellular vesicle

[Term]
id: GO:0070063
name: RNA polymerase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase molecule or complex." [GOC:BHF, GOC:mah, GOC:txnOH]
subset: gosubset_prok
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0070064
name: proline-rich region binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a proline-rich region, i.e. a region that contains a high proportion of proline residues, in a protein." [GOC:mah]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0070065
name: cellubrevin-VAMP4-syntaxin-16 complex
namespace: cellular_component
def: "A SNARE complex that contains cellubrevin (VAMP3), VAMP4, and syntaxin 16 (or orthologs thereof)." [PMID:11839770]
synonym: "SNARE complex (Vamp3, Vamp4, Stx16)" NARROW [CORUM:875]
synonym: "Vamp3-Vamp4-Stx16 complex" NARROW [CORUM:875]
is_a: GO:0031201 ! SNARE complex

[Term]
id: GO:0070066
name: cellubrevin-VAMP4-endobrevin-syntaxin-6 complex
namespace: cellular_component
def: "A SNARE complex that contains cellubrevin (VAMP3), VAMP4, endobrevin (VAMP8), and syntaxin 6 (or orthologs thereof)." [PMID:11839770]
synonym: "SNARE complex (Vamp3, Vamp4, Vam8, Stx6)" NARROW [CORUM:874]
synonym: "Vamp3-Vamp4-Vam8-Stx6 complex" NARROW [CORUM:874]
is_a: GO:0031201 ! SNARE complex

[Term]
id: GO:0070067
name: syntaxin-6-syntaxin-16-Vti1a complex
namespace: cellular_component
def: "A SNARE complex that contains syntaxin 6, syntaxin 16, and Vti1a (or orthologs thereof)." [PMID:11839770]
is_a: GO:0031201 ! SNARE complex

[Term]
id: GO:0070068
name: VAMP4-syntaxin-6-syntaxin-16-Vti1a complex
namespace: cellular_component
def: "A SNARE complex that contains VAMP4, syntaxin 6, syntaxin 16, and Vti1a (or orthologs thereof)." [PMID:11839770]
synonym: "SNARE complex (Vamp4, Stx6, Stx16, Vti1a)" NARROW [CORUM:877]
synonym: "Vamp4-Stx6-Stx16-Vti1a complex" RELATED [CORUM:877]
is_a: GO:0031201 ! SNARE complex

[Term]
id: GO:0070069
name: cytochrome complex
namespace: cellular_component
def: "A protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions." [GOC:mah]
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0070070
name: proton-transporting V-type ATPase complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a proton-transporting V-type ATPase complex, proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient." [GOC:mah]
synonym: "V-ATPase assembly" RELATED []
synonym: "V-ATPase complex assembly" RELATED []
is_a: GO:0070071 ! proton-transporting two-sector ATPase complex assembly

[Term]
id: GO:0070071
name: proton-transporting two-sector ATPase complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a proton-transporting two-sector ATPase complex, a large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane." [GOC:mah]
subset: gosubset_prok
is_a: GO:0043623 ! cellular protein complex assembly

[Term]
id: GO:0070072
name: vacuolar proton-transporting V-type ATPase complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a vacuolar proton-transporting V-type ATPase complex, proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across the vacuolar membrane." [GOC:BHF, GOC:mah]
synonym: "V-ATPase assembly" BROAD []
synonym: "V-ATPase complex assembly" BROAD []
is_a: GO:0070070 ! proton-transporting V-type ATPase complex assembly

[Term]
id: GO:0070073
name: clustering of voltage-gated calcium channels
namespace: biological_process
def: "The process in which voltage-gated calcium channels become localized together in high densities." [GOC:BHF, GOC:sart, PMID:18385325]
synonym: "clustering of voltage gated calcium channels" EXACT []
synonym: "clustering of voltage-dependent calcium channels" EXACT []
synonym: "voltage-gated calcium channel clustering" EXACT []
is_a: GO:0045161 ! neuronal ion channel clustering

[Term]
id: GO:0070074
name: mononeme
namespace: cellular_component
def: "A secretory organelle that forms part of the apical complex; a small, threadlike structure located is close proximity to the subpellicular microtubules. Its contents include a rhomboid protease (PfROM1 in Plasmodium falciparum) that moves from the lateral asymmetric localization to the merozoite apical pole and the posterior pole upon release of merozoites from schizonts." [GOC:BHF, PMID:18048320]
is_a: GO:0043231 ! intracellular membrane-bounded organelle
relationship: part_of GO:0020007 ! apical complex

[Term]
id: GO:0070075
name: tear secretion
namespace: biological_process
def: "The regulated release of the aqueous layer of the tear film from the lacrimal glands. Tears are the liquid product of a process of lacrimation to clean and lubricate the eyes. Tear fluid contains water, mucin, lipids, lysozyme, lactoferrin, lipocalin, lacritin, immunoglobulins, glucose, urea, sodium, and potassium." [GOC:rph]
is_a: GO:0007589 ! body fluid secretion
is_a: GO:0032941 ! secretion by tissue

[Term]
id: GO:0070076
name: histone lysine demethylation
namespace: biological_process
def: "The modification of a histone by the removal of a methyl group from a lysine residue." [GOC:mah]
is_a: GO:0016577 ! histone demethylation

[Term]
id: GO:0070077
name: histone arginine demethylation
namespace: biological_process
def: "The modification of a histone by the removal of a methyl group from an arginine residue." [GOC:mah]
is_a: GO:0016577 ! histone demethylation

[Term]
id: GO:0070078
name: histone H3-R2 demethylation
namespace: biological_process
def: "The modification of histone H3 by the removal of a methyl group from arginine at position 2 of the histone." [GOC:BHF, GOC:vk]
is_a: GO:0070077 ! histone arginine demethylation

[Term]
id: GO:0070079
name: histone H4-R3 demethylation
namespace: biological_process
def: "The modification of histone H4 by the removal of a methyl group from arginine at position 3 of the histone." [GOC:BHF, GOC:vk]
is_a: GO:0070077 ! histone arginine demethylation

[Term]
id: GO:0070080
name: titin Z domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the titin Z domain, which recognizes and binds to the C-terminal calmodulin-like domain of alpha-actinin-2 (Act-EF34), adopts a helical structure, and binds in a groove formed by the two planes between the helix pairs of Act-EF34." [GOC:mah, InterPro:IPR015129]
synonym: "Z repeat domain binding" EXACT []
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0070081
name: clathrin-sculpted monoamine transport vesicle
namespace: cellular_component
def: "A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing monoamines." [GOC:mg2]
synonym: "clathrin sculpted monoamine constitutive secretory pathway transport vesicle" EXACT []
synonym: "clathrin sculpted monoamine transport vesicle" EXACT [GOC:sl]
is_a: GO:0030133 ! transport vesicle
is_a: GO:0060198 ! clathrin-sculpted vesicle

[Term]
id: GO:0070082
name: clathrin-sculpted monoamine transport vesicle lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of the clathrin-sculpted monoamine transport vesicle." [GOC:mg2]
synonym: "clathrin sculpted monoamine constitutive secretory pathway transport vesicle lumen" EXACT []
synonym: "clathrin sculpted monoamine transport vesicle lumen" EXACT [GOC:sl]
is_a: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen
relationship: part_of GO:0070081 ! clathrin-sculpted monoamine transport vesicle

[Term]
id: GO:0070083
name: clathrin-sculpted monoamine transport vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a clathrin-sculpted monoamine transport vesicle." [GOC:mg2]
synonym: "clathrin sculpted monoamine constitutive secretory pathway transport vesicle membrane" EXACT []
synonym: "clathrin sculpted monoamine transport vesicle membrane" EXACT [GOC:sl]
is_a: GO:0030658 ! transport vesicle membrane
is_a: GO:0030665 ! clathrin-coated vesicle membrane
relationship: part_of GO:0070081 ! clathrin-sculpted monoamine transport vesicle

[Term]
id: GO:0070084
name: protein initiator methionine removal
namespace: biological_process
def: "The protein modification process in which the translation-initiating methionine or formylmethionine residue is removed from a protein." [GOC:imk, GOC:mah]
synonym: "removal of initiator methionine from protein" EXACT []
is_a: GO:0006464 ! cellular protein modification process

[Term]
id: GO:0070085
name: glycosylation
namespace: biological_process
def: "The covalent attachment and further modification of carbohydrate residues to a substrate molecule." [GOC:hjd, GOC:mah]
xref: Wikipedia:Glycosylation
is_a: GO:0044723 ! single-organism carbohydrate metabolic process

[Term]
id: GO:0070086
name: ubiquitin-dependent endocytosis
namespace: biological_process
def: "Endocytosis of a protein that requires the substrate to be modified by ubiquitination. Several plasma membrane proteins, including cell surface permeases and some receptors, are targeted for internalization by endocytosis, and are thereafter delivered to the vacuole or lysosome, where they are degraded." [GOC:jp, GOC:mah, PMID:9409540]
synonym: "ubiquitin-mediated endocytosis" EXACT [GOC:jp]
is_a: GO:0006897 ! endocytosis
is_a: GO:0015031 ! protein transport
is_a: GO:0044765 ! single-organism transport

[Term]
id: GO:0070087
name: chromo shadow domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a chromo shadow domain, a protein domain that is distantly related, and found in association with, the chromo domain." [GOC:BHF, GOC:vk, InterPro:IPR008251, PMID:7667093]
synonym: "chromoshadow domain binding" EXACT [GOC:vk]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0070088
name: PHA granule
namespace: cellular_component
def: "An inclusion body located in the cytoplasm that consists of polyhydroxyalkanoate (PHA) molecules and associated proteins, surrounded by a phospholipid monolayer; the proteins include PHA synthase, PHA depolymerase and 3HB-oligomer hydroxylase, phasins (PhaPs), which are thought to be the major structural proteins of the membrane surrounding the inclusion, and the regulator of phasin expression PhaR." [GOC:mah, PMID:15762612]
subset: gosubset_prok
synonym: "PHB granule" NARROW []
synonym: "polyhydroxyalkanoate granule" EXACT []
is_a: GO:0016234 ! inclusion body
is_a: GO:0043231 ! intracellular membrane-bounded organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0070089
name: chloride-activated potassium channel activity
namespace: molecular_function
def: "Enables the chloride concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient." [GOC:kmv, GOC:mtg_transport]
subset: gosubset_prok
is_a: GO:0005267 ! potassium channel activity
is_a: GO:0022839 ! ion gated channel activity

[Term]
id: GO:0070090
name: metaphase plate
namespace: cellular_component
def: "The intracellular plane, located halfway between the poles of the spindle, where chromosomes align during metaphase of mitotic or meiotic nuclear division." [GOC:mah]
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0070091
name: glucagon secretion
namespace: biological_process
def: "The regulated release of glucagon from secretory granules in the A (alpha) cells of the pancreas (islets of Langerhans)." [GOC:BHF, GOC:rl]
is_a: GO:0030072 ! peptide hormone secretion

[Term]
id: GO:0070092
name: regulation of glucagon secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of glucagon." [GOC:BHF, GOC:mah]
is_a: GO:0090276 ! regulation of peptide hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070091 ! glucagon secretion
relationship: regulates GO:0070091 ! glucagon secretion

[Term]
id: GO:0070093
name: negative regulation of glucagon secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of glucagon." [GOC:BHF, GOC:mah]
synonym: "down regulation of glucagon secretion" EXACT []
synonym: "down-regulation of glucagon secretion" EXACT []
synonym: "downregulation of glucagon secretion" EXACT []
synonym: "inhibition of glucagon secretion" NARROW []
is_a: GO:0070092 ! regulation of glucagon secretion
is_a: GO:0090278 ! negative regulation of peptide hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070091 ! glucagon secretion
relationship: negatively_regulates GO:0070091 ! glucagon secretion

[Term]
id: GO:0070094
name: positive regulation of glucagon secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of glucagon." [GOC:BHF, GOC:mah]
synonym: "activation of glucagon secretion" NARROW []
synonym: "stimulation of glucagon secretion" NARROW []
synonym: "up regulation of glucagon secretion" EXACT []
synonym: "up-regulation of glucagon secretion" EXACT []
synonym: "upregulation of glucagon secretion" EXACT []
is_a: GO:0070092 ! regulation of glucagon secretion
is_a: GO:0090277 ! positive regulation of peptide hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070091 ! glucagon secretion
relationship: positively_regulates GO:0070091 ! glucagon secretion

[Term]
id: GO:0070095
name: fructose-6-phosphate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with fructose 6-phosphate." [GOC:mah]
synonym: "D-fructose 6-phosphate binding" NARROW []
synonym: "fructose 6-phosphate binding" EXACT []
is_a: GO:0043168 ! anion binding
is_a: GO:0097367 ! carbohydrate derivative binding

[Term]
id: GO:0070096
name: mitochondrial outer membrane translocase complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a mitochondrial outer membrane translocase complex." [GOC:BHF, GOC:vk]
synonym: "TOM complex assembly" EXACT []
is_a: GO:0043623 ! cellular protein complex assembly
relationship: part_of GO:0007008 ! outer mitochondrial membrane organization

[Term]
id: GO:0070097
name: delta-catenin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the delta subunit of the catenin complex." [GOC:rph]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0070098
name: chemokine-mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of a chemokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling]
synonym: "chemokine-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0019221 ! cytokine-mediated signaling pathway

[Term]
id: GO:0070099
name: regulation of chemokine-mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the series of molecular events generated as a consequence of a chemokine binding to a cell surface receptor." [GOC:mah]
synonym: "regulation of chemokine-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070098 ! chemokine-mediated signaling pathway
relationship: regulates GO:0070098 ! chemokine-mediated signaling pathway

[Term]
id: GO:0070100
name: negative regulation of chemokine-mediated signaling pathway
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of a chemokine binding to a cell surface receptor." [GOC:mah]
synonym: "negative regulation of chemokine-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway
is_a: GO:0070099 ! regulation of chemokine-mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070098 ! chemokine-mediated signaling pathway
relationship: negatively_regulates GO:0070098 ! chemokine-mediated signaling pathway

[Term]
id: GO:0070101
name: positive regulation of chemokine-mediated signaling pathway
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the series of molecular events generated as a consequence of a chemokine binding to a cell surface receptor." [GOC:mah]
synonym: "positive regulation of chemokine-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway
is_a: GO:0070099 ! regulation of chemokine-mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070098 ! chemokine-mediated signaling pathway
relationship: positively_regulates GO:0070098 ! chemokine-mediated signaling pathway

[Term]
id: GO:0070102
name: interleukin-6-mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of interleukin-6 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:add, GOC:BHF, GOC:mah, GOC:signaling]
synonym: "IL-6-mediated signaling pathway" RELATED []
synonym: "interleukin-6-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0019221 ! cytokine-mediated signaling pathway
relationship: part_of GO:0071354 ! cellular response to interleukin-6

[Term]
id: GO:0070103
name: regulation of interleukin-6-mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-6-mediated binding to a cell surface receptor." [GOC:BHF, GOC:mah]
synonym: "regulation of IL-6-mediated signaling pathway" EXACT [GOC:mah]
synonym: "regulation of interleukin-6-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070102 ! interleukin-6-mediated signaling pathway
relationship: regulates GO:0070102 ! interleukin-6-mediated signaling pathway

[Term]
id: GO:0070104
name: negative regulation of interleukin-6-mediated signaling pathway
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-6 binding to a cell surface receptor." [GOC:BHF, GOC:mah]
synonym: "negative regulation of IL-6-mediated signaling pathway" EXACT [GOC:mah]
synonym: "negative regulation of interleukin-6-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway
is_a: GO:0070103 ! regulation of interleukin-6-mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070102 ! interleukin-6-mediated signaling pathway
relationship: negatively_regulates GO:0070102 ! interleukin-6-mediated signaling pathway

[Term]
id: GO:0070105
name: positive regulation of interleukin-6-mediated signaling pathway
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-6 binding to a cell surface receptor." [GOC:BHF, GOC:mah]
synonym: "positive regulation of IL-6-mediated signaling pathway" EXACT [GOC:mah]
synonym: "positive regulation of interleukin-6-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway
is_a: GO:0070103 ! regulation of interleukin-6-mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070102 ! interleukin-6-mediated signaling pathway
relationship: positively_regulates GO:0070102 ! interleukin-6-mediated signaling pathway

[Term]
id: GO:0070106
name: interleukin-27-mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of interleukin-27 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:add, GOC:BHF, GOC:mah, GOC:signaling]
synonym: "IL-27-mediated signaling pathway" EXACT [GOC:mah]
synonym: "IL27RA/IL6ST signaling pathway" EXACT [GOC:add]
synonym: "interleukin-27-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0019221 ! cytokine-mediated signaling pathway

[Term]
id: GO:0070107
name: regulation of interleukin-27-mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-27-mediated binding to a cell surface receptor." [GOC:BHF, GOC:mah]
synonym: "regulation of IL-27-mediated signaling pathway" EXACT [GOC:mah]
synonym: "regulation of IL27RA/IL6ST signaling pathway" EXACT [GOC:add]
synonym: "regulation of interleukin-27-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070106 ! interleukin-27-mediated signaling pathway
relationship: regulates GO:0070106 ! interleukin-27-mediated signaling pathway

[Term]
id: GO:0070108
name: negative regulation of interleukin-27-mediated signaling pathway
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-27 binding to a cell surface receptor." [GOC:BHF, GOC:mah]
synonym: "negative regulation of IL-27-mediated signaling pathway" EXACT [GOC:mah]
synonym: "negative regulation of IL27RA/IL6ST signaling pathway" EXACT [GOC:add]
synonym: "negative regulation of interleukin-27-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway
is_a: GO:0070107 ! regulation of interleukin-27-mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070106 ! interleukin-27-mediated signaling pathway
relationship: negatively_regulates GO:0070106 ! interleukin-27-mediated signaling pathway

[Term]
id: GO:0070109
name: positive regulation of interleukin-27-mediated signaling pathway
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-27 binding to a cell surface receptor." [GOC:BHF, GOC:mah]
synonym: "positive regulation of IL-27-mediated signaling pathway" EXACT [GOC:mah]
synonym: "positive regulation of IL27RA/IL6ST signaling pathway" EXACT [GOC:add]
synonym: "positive regulation of interleukin-27-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway
is_a: GO:0070107 ! regulation of interleukin-27-mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070106 ! interleukin-27-mediated signaling pathway
relationship: positively_regulates GO:0070106 ! interleukin-27-mediated signaling pathway

[Term]
id: GO:0070110
name: ciliary neurotrophic factor receptor complex
namespace: cellular_component
def: "A protein complex that acts as a receptor for the cytokine ciliary neurotrophic factor (CNTF). In humans the receptor complex is a hexamer composed of two molecules each of CNTF and CNTFR and one molecule each of gp130 and LIFR." [GOC:BHF, GOC:mah, GOC:rl, PMID:12707266]
is_a: GO:0098802 ! plasma membrane receptor complex
relationship: part_of GO:0005887 ! integral component of plasma membrane

[Term]
id: GO:0070111
name: organellar chromatophore
namespace: cellular_component
def: "A bacteroid-containing symbiosome in which the bacterial component is a genetically highly reduced cyanobacterium that is photosynthetically active and incapable of an independent existence outside its host. The chromatophore functions as a photosynthetic organelle, and has been found and characterized in the amoeba Paulinella chromatophora." [GOC:expert_mm, PMID:18356055]
synonym: "Paulinella-type chromatophore" EXACT []
is_a: GO:0043660 ! bacteroid-containing symbiosome

[Term]
id: GO:0070112
name: organellar chromatophore membrane
namespace: cellular_component
def: "Either of the lipid bilayers that surround an organellar chromatophore." [GOC:mah]
subset: gosubset_prok
synonym: "Paulinella-type chromatophore membrane" EXACT [GOC:mah]
is_a: GO:0030659 ! cytoplasmic vesicle membrane
relationship: part_of GO:0070111 ! organellar chromatophore

[Term]
id: GO:0070113
name: organellar chromatophore inner membrane
namespace: cellular_component
def: "The inner, i.e. lumen-facing, of the two lipid bilayers surrounding an organellar chromatophore." [GOC:mah]
synonym: "Paulinella-type chromatophore inner membrane" EXACT [GOC:mah]
is_a: GO:0070112 ! organellar chromatophore membrane

[Term]
id: GO:0070114
name: organellar chromatophore outer membrane
namespace: cellular_component
def: "The outer, i.e. cytoplasm-facing, of the two lipid bilayers surrounding an organellar chromatophore." [GOC:mah]
synonym: "Paulinella-type chromatophore outer membrane" EXACT [GOC:mah]
is_a: GO:0043661 ! peribacteroid membrane
is_a: GO:0070112 ! organellar chromatophore membrane

[Term]
id: GO:0070115
name: organellar chromatophore intermembrane space
namespace: cellular_component
def: "The region between the inner and outer lipid bilayers that surround an organellar chromatophore." [GOC:mah]
subset: gosubset_prok
synonym: "Paulinella-type chromatophore intermembrane space" EXACT [GOC:mah]
is_a: GO:0044433 ! cytoplasmic vesicle part
relationship: part_of GO:0070111 ! organellar chromatophore

[Term]
id: GO:0070116
name: organellar chromatophore thylakoid
namespace: cellular_component
def: "A thylakoid located in an organellar chromatophore." [GOC:mah]
subset: gosubset_prok
synonym: "Paulinella-type chromatophore thylakoid" EXACT [GOC:mah]
is_a: GO:0009579 ! thylakoid
is_a: GO:0044433 ! cytoplasmic vesicle part
relationship: part_of GO:0070111 ! organellar chromatophore

[Term]
id: GO:0070117
name: organellar chromatophore thylakoid lumen
namespace: cellular_component
def: "The volume enclosed by an organellar chromatophore thylakoid membrane." [GOC:mah]
synonym: "Paulinella-type chromatophore thylakoid lumen" EXACT [GOC:mah]
is_a: GO:0031977 ! thylakoid lumen
is_a: GO:0044433 ! cytoplasmic vesicle part
relationship: part_of GO:0070116 ! organellar chromatophore thylakoid

[Term]
id: GO:0070118
name: organellar chromatophore thylakoid membrane
namespace: cellular_component
def: "The lipid bilayer membrane of any thylakoid within an organellar chromatophore." [GOC:mah]
synonym: "Paulinella-type chromatophore thylakoid membrane" EXACT [GOC:mah]
is_a: GO:0042651 ! thylakoid membrane
is_a: GO:0044433 ! cytoplasmic vesicle part
relationship: part_of GO:0070116 ! organellar chromatophore thylakoid

[Term]
id: GO:0070119
name: ciliary neurotrophic factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the cytokine ciliary neurotrophic factor." [GOC:BHF, GOC:mah]
synonym: "CNTF binding" EXACT [GOC:mah]
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0070120
name: ciliary neurotrophic factor-mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of a ciliary neurotrophic factor (CNTF) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:mah]
synonym: "ciliary neurotrophic factor-mediated signalling pathway" EXACT [GOC:mah]
synonym: "CNTF-mediated signaling pathway" EXACT [GOC:rl]
is_a: GO:0019221 ! cytokine-mediated signaling pathway

[Term]
id: GO:0070121
name: Kupffer's vesicle development
namespace: biological_process
def: "The progression of the Kupffer's vesicle over time from its initial formation until its mature state. The Kupffer's vesicle is a small but distinctive epithelial sac containing fluid, located midventrally posterior to the yolk cell or its extension, and transiently present during most of the segmentation period." [GOC:dgh]
synonym: "KV development" EXACT [GOC:dgh]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development

[Term]
id: GO:0070122
name: isopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of an isopeptide bond. An isopeptide bond is an amide linkage between a carboxyl group of one amino acid and an amino group of another amino acid in which at least one of these groups is not on the a-carbon of one of the amino acids (for example, the link between an epsilon-amino group of a lysine molecule to a carboxyl group on a second amino acid is an isopeptide bond)." [GOC:mah, http://128.240.24.212/cgi-bin/omd?isopeptide+bond]
is_a: GO:0008233 ! peptidase activity

[Term]
id: GO:0070123
name: transforming growth factor beta receptor activity, type III
namespace: molecular_function
def: "Combining with transforming growth factor beta to initiate a change in cell activity; facilitates ligand binding to type I and type II TGF-beta receptors." [GOC:BHF, GOC:mah, PMID:9759503]
synonym: "betaglycan" NARROW []
synonym: "endoglin" NARROW []
synonym: "transforming growth factor beta ligand binding to type III receptor" RELATED []
synonym: "type III TGF-beta receptor activity" EXACT []
synonym: "type III TGFbeta receptor activity" EXACT []
synonym: "type III transforming growth factor beta receptor activity" EXACT []
is_a: GO:0005024 ! transforming growth factor beta-activated receptor activity

[Term]
id: GO:0070124
name: mitochondrial translational initiation
namespace: biological_process
def: "The process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [GOC:mah]
synonym: "mitochondrial translation initiation" EXACT [GOC:mah]
is_a: GO:0006413 ! translational initiation
intersection_of: GO:0006413 ! translational initiation
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion
relationship: part_of GO:0032543 ! mitochondrial translation

[Term]
id: GO:0070125
name: mitochondrial translational elongation
namespace: biological_process
def: "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in a mitochondrion." [GOC:mah]
synonym: "mitochondrial translation elongation" EXACT [GOC:mah]
is_a: GO:0006414 ! translational elongation
intersection_of: GO:0006414 ! translational elongation
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion
relationship: part_of GO:0032543 ! mitochondrial translation

[Term]
id: GO:0070126
name: mitochondrial translational termination
namespace: biological_process
def: "The process resulting in the release of a polypeptide chain from the ribosome in a mitochondrion, usually in response to a termination codon (note that mitochondria use variants of the universal genetic code that differ between different taxa)." [GOC:mah, http://mitogenome.org/index.php/Genetic_Code_of_mitochondria]
synonym: "mitochondrial translation termination" EXACT [GOC:mah]
is_a: GO:0006415 ! translational termination
intersection_of: GO:0006415 ! translational termination
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion
relationship: part_of GO:0032543 ! mitochondrial translation

[Term]
id: GO:0070127
name: tRNA aminoacylation for mitochondrial protein translation
namespace: biological_process
def: "The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis in a mitochondrion." [GOC:mah]
is_a: GO:0000959 ! mitochondrial RNA metabolic process
is_a: GO:0006418 ! tRNA aminoacylation for protein translation
relationship: part_of GO:0032543 ! mitochondrial translation

[Term]
id: GO:0070129
name: regulation of mitochondrial translation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion." [GOC:mah]
synonym: "regulation of mitochondrial protein anabolism" EXACT [GOC:mah]
synonym: "regulation of mitochondrial protein biosynthesis" EXACT [GOC:mah]
synonym: "regulation of mitochondrial protein formation" EXACT [GOC:mah]
synonym: "regulation of mitochondrial protein synthesis" EXACT [GOC:mah]
is_a: GO:0006417 ! regulation of translation
is_a: GO:0010821 ! regulation of mitochondrion organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032543 ! mitochondrial translation
relationship: regulates GO:0032543 ! mitochondrial translation

[Term]
id: GO:0070130
name: negative regulation of mitochondrial translation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion." [GOC:mah]
synonym: "negative regulation of mitochondrial protein anabolism" EXACT [GOC:mah]
synonym: "negative regulation of mitochondrial protein biosynthesis" EXACT [GOC:mah]
synonym: "negative regulation of mitochondrial protein formation" EXACT [GOC:mah]
synonym: "negative regulation of mitochondrial protein synthesis" EXACT [GOC:mah]
is_a: GO:0010823 ! negative regulation of mitochondrion organization
is_a: GO:0017148 ! negative regulation of translation
is_a: GO:0070129 ! regulation of mitochondrial translation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032543 ! mitochondrial translation
relationship: negatively_regulates GO:0032543 ! mitochondrial translation

[Term]
id: GO:0070131
name: positive regulation of mitochondrial translation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion." [GOC:mah]
synonym: "positive regulation of mitochondrial protein anabolism" EXACT [GOC:mah]
synonym: "positive regulation of mitochondrial protein biosynthesis" EXACT [GOC:mah]
synonym: "positive regulation of mitochondrial protein formation" EXACT [GOC:mah]
synonym: "positive regulation of mitochondrial protein synthesis" EXACT [GOC:mah]
is_a: GO:0010822 ! positive regulation of mitochondrion organization
is_a: GO:0045727 ! positive regulation of translation
is_a: GO:0070129 ! regulation of mitochondrial translation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032543 ! mitochondrial translation
relationship: positively_regulates GO:0032543 ! mitochondrial translation

[Term]
id: GO:0070132
name: regulation of mitochondrial translational initiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion." [GOC:mah]
synonym: "regulation of mitochondrial translation initiation" EXACT [GOC:mah]
is_a: GO:0006446 ! regulation of translational initiation
is_a: GO:0070129 ! regulation of mitochondrial translation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070124 ! mitochondrial translational initiation
relationship: regulates GO:0070124 ! mitochondrial translational initiation

[Term]
id: GO:0070133
name: negative regulation of mitochondrial translational initiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion." [GOC:mah]
synonym: "negative regulation of mitochondrial translation initiation" EXACT [GOC:mah]
is_a: GO:0045947 ! negative regulation of translational initiation
is_a: GO:0070130 ! negative regulation of mitochondrial translation
is_a: GO:0070132 ! regulation of mitochondrial translational initiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070124 ! mitochondrial translational initiation
relationship: negatively_regulates GO:0070124 ! mitochondrial translational initiation

[Term]
id: GO:0070134
name: positive regulation of mitochondrial translational initiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion." [GOC:mah]
synonym: "positive regulation of mitochondrial translation initiation" EXACT [GOC:mah]
is_a: GO:0045948 ! positive regulation of translational initiation
is_a: GO:0070131 ! positive regulation of mitochondrial translation
is_a: GO:0070132 ! regulation of mitochondrial translational initiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070124 ! mitochondrial translational initiation
relationship: positively_regulates GO:0070124 ! mitochondrial translational initiation

[Term]
id: GO:0070135
name: beta-1,2-oligomannoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving beta-1,2-linked oligomannosides, which are found in fungal cell wall phosphopeptidomannan and phospholipomannan." [GOC:mah, PMID:18234669]
synonym: "beta-1,2-oligomannoside metabolism" EXACT [GOC:mah]
is_a: GO:0010383 ! cell wall polysaccharide metabolic process
is_a: GO:0010412 ! mannan metabolic process
is_a: GO:0044723 ! single-organism carbohydrate metabolic process
is_a: GO:0044763 ! single-organism cellular process

[Term]
id: GO:0070136
name: beta-1,2-oligomannoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of beta-1,2-linked oligomannosides, which are found in fungal cell wall phosphopeptidomannan and phospholipomannan." [GOC:mah, PMID:18234669]
synonym: "beta-1,2-oligomannoside anabolism" EXACT [GOC:mah]
synonym: "beta-1,2-oligomannoside biosynthesis" EXACT [GOC:mah]
synonym: "beta-1,2-oligomannoside formation" EXACT [GOC:mah]
synonym: "beta-1,2-oligomannoside synthesis" EXACT [GOC:mah]
is_a: GO:0046354 ! mannan biosynthetic process
is_a: GO:0051278 ! fungal-type cell wall polysaccharide biosynthetic process
is_a: GO:0070135 ! beta-1,2-oligomannoside metabolic process

[Term]
id: GO:0070137
name: ubiquitin-like protein-specific endopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of peptide bonds between an alpha-carboxyl group and an alpha-amino group within a small protein such as ubiquitin or a ubiquitin-like protein (e.g. APG8, ISG15, NEDD8, SUMO)." [GOC:mah]
synonym: "small conjugating protein-specific endopeptidase activity" EXACT []
is_a: GO:0004197 ! cysteine-type endopeptidase activity
is_a: GO:0019783 ! ubiquitin-like protein-specific protease activity

[Term]
id: GO:0070138
name: ubiquitin-like protein-specific isopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of an isopeptide bond between a small protein such as ubiquitin or a ubiquitin-like protein (e.g. APG8, ISG15, NEDD8, SUMO) and a protein to which the small protein has been conjugated." [GOC:mah]
synonym: "small conjugating protein-specific isopeptidase activity" EXACT [GOC:dph]
is_a: GO:0019783 ! ubiquitin-like protein-specific protease activity
is_a: GO:0070122 ! isopeptidase activity

[Term]
id: GO:0070139
name: SUMO-specific endopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of peptide bonds between an alpha-carboxyl group and an alpha-amino group within the small conjugating protein SUMO." [GOC:mah]
is_a: GO:0016929 ! SUMO-specific protease activity
is_a: GO:0070137 ! ubiquitin-like protein-specific endopeptidase activity

[Term]
id: GO:0070140
name: SUMO-specific isopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of an isopeptide bond between the small conjugating protein SUMO and a protein to which SUMO has been conjugated." [GOC:mah]
is_a: GO:0016929 ! SUMO-specific protease activity
is_a: GO:0070138 ! ubiquitin-like protein-specific isopeptidase activity

[Term]
id: GO:0070141
name: response to UV-A
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-A radiation stimulus. UV-A radiation (UV-A light) spans the wavelengths 315 to 400 nm." [GOC:BHF, GOC:mah]
synonym: "response to UV-A light stimulus" EXACT []
synonym: "response to UV-A radiation stimulus" EXACT []
synonym: "response to UVA light stimulus" EXACT []
synonym: "response to UVA radiation stimulus" EXACT []
is_a: GO:0009411 ! response to UV

[Term]
id: GO:0070142
name: synaptic vesicle budding
namespace: biological_process
def: "Evagination of a membrane to form a synaptic vesicle." [GOC:mah]
is_a: GO:0006900 ! membrane budding
relationship: part_of GO:0048489 ! synaptic vesicle transport

[Term]
id: GO:0070143
name: mitochondrial alanyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling alanine to alanyl-tRNA in a mitochondrion, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006419 ! alanyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation
intersection_of: GO:0006419 ! alanyl-tRNA aminoacylation
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion

[Term]
id: GO:0070144
name: mitochondrial arginyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling arginine to arginyl-tRNA in a mitochondrion, catalyzed by arginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006420 ! arginyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation
intersection_of: GO:0006420 ! arginyl-tRNA aminoacylation
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion

[Term]
id: GO:0070145
name: mitochondrial asparaginyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling asparagine to asparaginyl-tRNA in a mitochondrion, catalyzed by asparaginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006421 ! asparaginyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation
intersection_of: GO:0006421 ! asparaginyl-tRNA aminoacylation
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion

[Term]
id: GO:0070146
name: mitochondrial aspartyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling aspartate to aspartyl-tRNA in a mitochondrion, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006422 ! aspartyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation
intersection_of: GO:0006422 ! aspartyl-tRNA aminoacylation
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion

[Term]
id: GO:0070147
name: mitochondrial cysteinyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling cysteine to cysteinyl-tRNA in a mitochondrion, catalyzed by cysteinyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006423 ! cysteinyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation
intersection_of: GO:0006423 ! cysteinyl-tRNA aminoacylation
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion

[Term]
id: GO:0070148
name: mitochondrial glutaminyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling glutamine to glutaminyl-tRNA in a mitochondrion, catalyzed by glutaminyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006425 ! glutaminyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation
intersection_of: GO:0006425 ! glutaminyl-tRNA aminoacylation
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion

[Term]
id: GO:0070149
name: mitochondrial glutamyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling glutamate to glutamyl-tRNA in a mitochondrion, catalyzed by glutamyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006424 ! glutamyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation
intersection_of: GO:0006424 ! glutamyl-tRNA aminoacylation
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion

[Term]
id: GO:0070150
name: mitochondrial glycyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling glycine to glycyl-tRNA in a mitochondrion, catalyzed by glycyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006426 ! glycyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation
intersection_of: GO:0006426 ! glycyl-tRNA aminoacylation
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion

[Term]
id: GO:0070151
name: mitochondrial histidyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling histidine to histidyl-tRNA in a mitochondrion, catalyzed by histidyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006427 ! histidyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation
intersection_of: GO:0006427 ! histidyl-tRNA aminoacylation
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion

[Term]
id: GO:0070152
name: mitochondrial isoleucyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling isoleucine to isoleucyl-tRNA in a mitochondrion, catalyzed by isoleucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006428 ! isoleucyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation
intersection_of: GO:0006428 ! isoleucyl-tRNA aminoacylation
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion

[Term]
id: GO:0070153
name: mitochondrial leucyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling leucine to leucyl-tRNA in a mitochondrion, catalyzed by leucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006429 ! leucyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation
intersection_of: GO:0006429 ! leucyl-tRNA aminoacylation
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion

[Term]
id: GO:0070154
name: mitochondrial lysyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling lysine to lysyl-tRNA in a mitochondrion, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006430 ! lysyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation
intersection_of: GO:0006430 ! lysyl-tRNA aminoacylation
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion

[Term]
id: GO:0070155
name: mitochondrial methionyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling methionine to methionyl-tRNA in a mitochondrion, catalyzed by methionyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006431 ! methionyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation
intersection_of: GO:0006431 ! methionyl-tRNA aminoacylation
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion

[Term]
id: GO:0070156
name: mitochondrial phenylalanyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling phenylalanine to phenylalanyl-tRNA in a mitochondrion, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006432 ! phenylalanyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation
intersection_of: GO:0006432 ! phenylalanyl-tRNA aminoacylation
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion

[Term]
id: GO:0070157
name: mitochondrial prolyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling proline to prolyl-tRNA in a mitochondrion, catalyzed by prolyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006433 ! prolyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation
intersection_of: GO:0006433 ! prolyl-tRNA aminoacylation
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion

[Term]
id: GO:0070158
name: mitochondrial seryl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling serine to seryl-tRNA in a mitochondrion, catalyzed by seryl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006434 ! seryl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation
intersection_of: GO:0006434 ! seryl-tRNA aminoacylation
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion

[Term]
id: GO:0070159
name: mitochondrial threonyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling threonine to threonyl-tRNA in a mitochondrion, catalyzed by threonyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006435 ! threonyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation
intersection_of: GO:0006435 ! threonyl-tRNA aminoacylation
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion

[Term]
id: GO:0070160
name: occluding junction
namespace: cellular_component
def: "A cell-cell junction that seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other." [ISBN:0815332181]
synonym: "occluding cell junction" EXACT [GOC:mah]
is_a: GO:0005911 ! cell-cell junction

[Term]
id: GO:0070161
name: anchoring junction
namespace: cellular_component
def: "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181]
synonym: "anchoring cell junction" EXACT [GOC:mah]
is_a: GO:0030054 ! cell junction

[Term]
id: GO:0070162
name: adiponectin secretion
namespace: biological_process
def: "The regulated release of adiponectin, a protein hormone, by adipose tissue." [GOC:BHF, GOC:rl]
is_a: GO:0009306 ! protein secretion
is_a: GO:0060986 ! endocrine hormone secretion

[Term]
id: GO:0070163
name: regulation of adiponectin secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of adiponectin from a cell." [GOC:mah]
is_a: GO:0044060 ! regulation of endocrine process
is_a: GO:0046883 ! regulation of hormone secretion
is_a: GO:0050708 ! regulation of protein secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070162 ! adiponectin secretion
relationship: regulates GO:0070162 ! adiponectin secretion

[Term]
id: GO:0070164
name: negative regulation of adiponectin secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of adiponectin from a cell." [GOC:BHF, GOC:mah]
synonym: "down regulation of adiponectin secretion" EXACT [GOC:mah]
synonym: "down-regulation of adiponectin secretion" EXACT [GOC:mah]
synonym: "downregulation of adiponectin secretion" EXACT [GOC:mah]
synonym: "inhibition of adiponectin secretion" NARROW [GOC:mah]
is_a: GO:0046888 ! negative regulation of hormone secretion
is_a: GO:0050709 ! negative regulation of protein secretion
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0070163 ! regulation of adiponectin secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070162 ! adiponectin secretion
relationship: negatively_regulates GO:0070162 ! adiponectin secretion

[Term]
id: GO:0070165
name: positive regulation of adiponectin secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of adiponectin from a cell." [GOC:BHF, GOC:mah]
synonym: "activation of adiponectin secretion" NARROW [GOC:mah]
synonym: "stimulation of adiponectin secretion" NARROW [GOC:mah]
synonym: "up regulation of adiponectin secretion" EXACT [GOC:mah]
synonym: "up-regulation of adiponectin secretion" EXACT [GOC:mah]
synonym: "upregulation of adiponectin secretion" EXACT [GOC:mah]
is_a: GO:0046887 ! positive regulation of hormone secretion
is_a: GO:0050714 ! positive regulation of protein secretion
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0070163 ! regulation of adiponectin secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070162 ! adiponectin secretion
relationship: positively_regulates GO:0070162 ! adiponectin secretion

[Term]
id: GO:0070166
name: enamel mineralization
namespace: biological_process
def: "The process in which calcium salts, mainly carbonated hydroxyapatite, are deposited in tooth enamel." [GOC:BHF, GOC:mah, GOC:sl, PMID:10206335, PMID:16931858, PMID:21196346]
synonym: "enamel formation" RELATED [PMID:16931858]
is_a: GO:0034505 ! tooth mineralization
relationship: part_of GO:0097186 ! amelogenesis

[Term]
id: GO:0070167
name: regulation of biomineral tissue development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds." [GOC:mah]
synonym: "regulation of biomineral formation" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of biomineralization" EXACT [GOC:mah]
synonym: "regulation of mineralization" EXACT [GOC:mah]
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031214 ! biomineral tissue development
relationship: regulates GO:0031214 ! biomineral tissue development

[Term]
id: GO:0070168
name: negative regulation of biomineral tissue development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds." [GOC:mah]
synonym: "negative regulation of biomineral formation" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of biomineralization" EXACT [GOC:mah]
synonym: "negative regulation of mineralization" EXACT [GOC:mah]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0070167 ! regulation of biomineral tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0031214 ! biomineral tissue development
relationship: negatively_regulates GO:0031214 ! biomineral tissue development

[Term]
id: GO:0070169
name: positive regulation of biomineral tissue development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds." [GOC:mah]
synonym: "positive regulation of biomineral formation" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of biomineralization" EXACT [GOC:mah]
synonym: "positive regulation of mineralization" EXACT [GOC:mah]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0070167 ! regulation of biomineral tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0031214 ! biomineral tissue development
relationship: positively_regulates GO:0031214 ! biomineral tissue development

[Term]
id: GO:0070170
name: regulation of tooth mineralization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tooth mineralization, the deposition of calcium salts in tooth structures." [GOC:BHF, GOC:mah]
is_a: GO:0042481 ! regulation of odontogenesis
is_a: GO:0070167 ! regulation of biomineral tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034505 ! tooth mineralization
relationship: regulates GO:0034505 ! tooth mineralization

[Term]
id: GO:0070171
name: negative regulation of tooth mineralization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of tooth mineralization, the deposition of calcium salts in tooth structures." [GOC:BHF, GOC:mah]
is_a: GO:0042483 ! negative regulation of odontogenesis
is_a: GO:0070168 ! negative regulation of biomineral tissue development
is_a: GO:0070170 ! regulation of tooth mineralization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034505 ! tooth mineralization
relationship: negatively_regulates GO:0034505 ! tooth mineralization

[Term]
id: GO:0070172
name: positive regulation of tooth mineralization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tooth mineralization, the deposition of calcium salts in tooth structures." [GOC:BHF, GOC:mah]
is_a: GO:0042482 ! positive regulation of odontogenesis
is_a: GO:0070169 ! positive regulation of biomineral tissue development
is_a: GO:0070170 ! regulation of tooth mineralization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034505 ! tooth mineralization
relationship: positively_regulates GO:0034505 ! tooth mineralization

[Term]
id: GO:0070173
name: regulation of enamel mineralization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of enamel mineralization, the deposition of calcium salts in tooth enamel." [GOC:BHF, GOC:mah]
is_a: GO:0042487 ! regulation of odontogenesis of dentin-containing tooth
is_a: GO:0070170 ! regulation of tooth mineralization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070166 ! enamel mineralization
relationship: regulates GO:0070166 ! enamel mineralization

[Term]
id: GO:0070174
name: negative regulation of enamel mineralization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of enamel mineralization, the deposition of calcium salts in tooth enamel." [GOC:BHF, GOC:mah]
is_a: GO:0042489 ! negative regulation of odontogenesis of dentin-containing tooth
is_a: GO:0070171 ! negative regulation of tooth mineralization
is_a: GO:0070173 ! regulation of enamel mineralization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070166 ! enamel mineralization
relationship: negatively_regulates GO:0070166 ! enamel mineralization

[Term]
id: GO:0070175
name: positive regulation of enamel mineralization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of enamel mineralization, the deposition of calcium salts in tooth enamel." [GOC:BHF, GOC:mah]
is_a: GO:0042488 ! positive regulation of odontogenesis of dentin-containing tooth
is_a: GO:0070172 ! positive regulation of tooth mineralization
is_a: GO:0070173 ! regulation of enamel mineralization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070166 ! enamel mineralization
relationship: positively_regulates GO:0070166 ! enamel mineralization

[Term]
id: GO:0070176
name: DRM complex
namespace: cellular_component
def: "A transcriptional repressor complex that contains the lin-9, lin-35, lin-37, lin-52, lin-53, lin-5is involved in 4-, dpl-1 and efl-1 proteins, and is involved in cell fate specification." [PMID:17075059]
synonym: "DP/Rb/MuvB" EXACT [PMID:17075059]
is_a: GO:0090571 ! RNA polymerase II transcription repressor complex

[Term]
id: GO:0070177
name: contractile vacuole discharge
namespace: biological_process
def: "The regulated release of water from a contractile vacuole to the outside of a cell by fusion of the contractile vacuole membrane with the plasma membrane." [GOC:mah, PMID:10369671]
is_a: GO:0016192 ! vesicle-mediated transport
is_a: GO:0032940 ! secretion by cell

[Term]
id: GO:0070178
name: D-serine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-serine, the D-enantiomer of serine, i.e. (2R)-2-amino-3-hydroxypropanoic acid." [CHEBI:16523, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "D-serine metabolism" EXACT []
is_a: GO:0009069 ! serine family amino acid metabolic process
is_a: GO:0046416 ! D-amino acid metabolic process

[Term]
id: GO:0070179
name: D-serine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of D-serine, the D-enantiomer of serine, i.e. (2R)-2-amino-3-hydroxypropanoic acid. D-serine is often formed by racemization of L-serine." [CHEBI:16523, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "D-serine anabolism" EXACT []
synonym: "D-serine biosynthesis" EXACT []
synonym: "D-serine formation" EXACT []
synonym: "D-serine synthesis" EXACT []
is_a: GO:0009070 ! serine family amino acid biosynthetic process
is_a: GO:0046437 ! D-amino acid biosynthetic process
is_a: GO:0070178 ! D-serine metabolic process

[Term]
id: GO:0070180
name: large ribosomal subunit rRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the large ribosomal subunit RNA (LSU rRNA), a constituent of the large ribosomal subunit. In S. cerevisiae, this is the 25S rRNA." [GOC:elh]
synonym: "25S rRNA binding" EXACT [GOC:elh]
synonym: "LSU rRNA binding" EXACT []
is_a: GO:0019843 ! rRNA binding

[Term]
id: GO:0070181
name: small ribosomal subunit rRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the small ribosomal subunit RNA (SSU rRNA), a constituent of the small ribosomal subunit. In S. cerevisiae, this is the 18S rRNA." [GOC:elh]
synonym: "18S rRNA binding" EXACT [GOC:elh]
synonym: "SSU rRNA binding" EXACT []
is_a: GO:0019843 ! rRNA binding

[Term]
id: GO:0070182
name: DNA polymerase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a DNA polymerase." [GOC:BHF, GOC:mah]
subset: gosubset_prok
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0070183
name: mitochondrial tryptophanyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling tryptophan to tryptophanyl-tRNA in a mitochondrion, catalyzed by tryptophanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006436 ! tryptophanyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation
intersection_of: GO:0006436 ! tryptophanyl-tRNA aminoacylation
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion

[Term]
id: GO:0070184
name: mitochondrial tyrosyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling tyrosine to tyrosyl-tRNA in a mitochondrion, catalyzed by tyrosyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006437 ! tyrosyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation
intersection_of: GO:0006437 ! tyrosyl-tRNA aminoacylation
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion

[Term]
id: GO:0070185
name: mitochondrial valyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling valine to valyl-tRNA in a mitochondrion, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006438 ! valyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation
intersection_of: GO:0006438 ! valyl-tRNA aminoacylation
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion

[Term]
id: GO:0070186
name: growth hormone activity
namespace: molecular_function
def: "The action characteristic of growth hormone, a peptide hormone that is secreted by the anterior pituitary or the placenta into the circulation, and binds to membrane receptors in target tissues to stimulate body growth." [GOC:BHF, GOC:mah, PMID:11445442]
synonym: "GH activity" EXACT [PMID:11445442]
synonym: "pituitary growth hormone activity" NARROW [GOC:vk]
synonym: "placental growth hormone activity" NARROW [GOC:vk]
is_a: GO:0005179 ! hormone activity

[Term]
id: GO:0070187
name: telosome
namespace: cellular_component
def: "A nuclear telomere cap complex that is formed by the association of telomeric ssDNA- and dsDNA-binding proteins with telomeric DNA, and is involved in telomere protection and recruitment of telomerase. The complex contains TRF1, TRF2, POT1, RAP1, TIN2 and TPP1 in mammalian cells, and Pot1, Tpz1, Ccq1, Poz1, Rap1, Rif1, Rif2and Rap1 in Schizosaccharomyces. Taz1 and Rap1 (or their mammalian equivalents) form a dsDNA-binding subcomplex, Pot1 and Tpz1 form an ssDNA-binding subcomplex, and the two subcomplexes are bridged by Poz1." [GOC:expert_mf, GOC:mah, GOC:vw, PMID:18828880]
synonym: "Pot1 complex" EXACT [GOC:vw]
synonym: "Pot1-Tpz1 complex" EXACT [GOC:vw]
synonym: "shelterin complex" EXACT [GOC:mah, GOC:vw]
is_a: GO:0000783 ! nuclear telomere cap complex

[Term]
id: GO:0070188
name: obsolete Stn1-Ten1 complex
namespace: cellular_component
def: "OBSOLETE. A nuclear telomere cap complex that is formed by the association of the Stn1 and Ten1 proteins with telomeric DNA; in some species a third protein is present." [GOC:mah, GOC:vw, PMID:17715303, PMID:19064932]
comment: This term was made obsolete because it was inaccurate.
is_obsolete: true
replaced_by: GO:1990879

[Term]
id: GO:0070189
name: kynurenine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving kynurenine, the amino acid 3-(2-aminobenzoyl)-alanine." [CHEBI:28683, GOC:mah, GOC:rph]
synonym: "kynurenine metabolism" EXACT []
is_a: GO:0006575 ! cellular modified amino acid metabolic process
is_a: GO:0042180 ! cellular ketone metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process
is_a: GO:1901605 ! alpha-amino acid metabolic process

[Term]
id: GO:0070190
name: obsolete inositol hexakisphosphate 1-kinase or 3-kinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 1-diphospho-1D-myo-inositol (2,3,4,5,6)pentakisphosphate, and ATP + 1D-myo-inositol hexakisphosphate = ADP + 3-diphospho-1D-myo-inositol (1,2,4,5,6)pentakisphosphate." [GOC:jp, PMID:18981179]
comment: This term was made obsolete because it represents two reactions, and should be two separate terms.
synonym: "inositol hexakisphosphate 1-kinase or 3-kinase activity" EXACT []
is_obsolete: true
consider: GO:0052723
consider: GO:0052724

[Term]
id: GO:0070191
name: methionine-R-sulfoxide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-methionine R-oxide + thioredoxin = L-methionine + thioredoxin disulfide; can act on free oxidized methionine with specificity for the R enantiomer; does not act on oxidized methionine in peptide linkage. Thioredoxin disulfide is the oxidized form of thioredoxin." [GOC:mcc, PMID:17535911, PMID:19049972]
xref: EC:1.8.4.-
is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor

[Term]
id: GO:0070192
name: chromosome organization involved in meiotic cell cycle
namespace: biological_process
def: "A process of chromosome organization that is involved in a meiotic cell cycle." [GOC:mah]
synonym: "chromosome organisation involved in meiosis" EXACT [GOC:mah]
synonym: "meiotic chromosome organization" EXACT [GOC:mah]
is_a: GO:0051276 ! chromosome organization
is_a: GO:1902589 ! single-organism organelle organization
is_a: GO:1903046 ! meiotic cell cycle process
intersection_of: GO:0051276 ! chromosome organization
intersection_of: part_of GO:0051321 ! meiotic cell cycle
relationship: part_of GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0070193
name: synaptonemal complex organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synaptonemal complex. A synaptonemal complex is a proteinaceous scaffold formed between homologous chromosomes during meiosis." [GOC:mah]
synonym: "synaptonemal complex organisation" EXACT [GOC:mah]
is_a: GO:0051276 ! chromosome organization

[Term]
id: GO:0070194
name: synaptonemal complex disassembly
namespace: biological_process
def: "The controlled breakdown of a synaptonemal complex." [GOC:mah]
is_a: GO:0022411 ! cellular component disassembly
is_a: GO:0070193 ! synaptonemal complex organization
is_a: GO:1902589 ! single-organism organelle organization

[Term]
id: GO:0070195
name: growth hormone receptor complex
namespace: cellular_component
def: "A receptor complex that consists of two identical subunits and binds growth hormone." [GOC:BHF, GOC:mah, GOC:vk, PMID:11445442]
is_a: GO:0043235 ! receptor complex

[Term]
id: GO:0070196
name: eukaryotic translation initiation factor 3 complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the eukaryotic translation initiation factor 3 complex." [GOC:mah]
synonym: "eIF-3 assembly" EXACT [GOC:mah]
synonym: "eIF3 assembly" EXACT [GOC:mah]
is_a: GO:0043623 ! cellular protein complex assembly

[Term]
id: GO:0070197
name: meiotic attachment of telomere to nuclear envelope
namespace: biological_process
def: "The meiotic cell cycle process in which physical connections are formed between telomeric heterochromatin and the nuclear envelope, facilitating bouquet formation." [GOC:jp, GOC:pr, GOC:vw, PMID:18818742]
synonym: "attachment of telomeres to nuclear envelope" BROAD []
synonym: "attachment of telomeric chromatin to nuclear envelope" BROAD []
synonym: "attachment of telomeric heterochromatin to nuclear envelope" EXACT []
is_a: GO:0097240 ! chromosome attachment to the nuclear envelope
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0044821 ! meiotic telomere tethering at nuclear periphery

[Term]
id: GO:0070198
name: protein localization to chromosome, telomeric region
namespace: biological_process
def: "Any process in which a protein is transported to, or maintained at, the telomeric region of a chromosome." [GOC:BHF, GOC:mah]
synonym: "protein localisation to chromosome, telomeric region" EXACT [GOC:mah]
synonym: "protein localization to telomere" EXACT [GOC:mah]
is_a: GO:0034502 ! protein localization to chromosome

[Term]
id: GO:0070199
name: establishment of protein localization to chromosome
namespace: biological_process
def: "The directed movement of a protein to a specific location on a chromosome." [GOC:BHF, GOC:mah]
synonym: "establishment of protein localisation to chromosome" EXACT [GOC:mah]
is_a: GO:0072594 ! establishment of protein localization to organelle
relationship: part_of GO:0034502 ! protein localization to chromosome

[Term]
id: GO:0070200
name: establishment of protein localization to telomere
namespace: biological_process
def: "The directed movement of a protein to a specific location in the telomeric region of a chromosome." [GOC:BHF, GOC:mah]
synonym: "establishment of protein localisation to telomere" EXACT [GOC:mah]
synonym: "establishment of protein localization to chromosome, telomeric region" EXACT [GOC:mah]
is_a: GO:0070199 ! establishment of protein localization to chromosome
relationship: part_of GO:0070198 ! protein localization to chromosome, telomeric region

[Term]
id: GO:0070201
name: regulation of establishment of protein localization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location." [GOC:BHF, GOC:mah]
synonym: "regulation of establishment of protein localisation" EXACT [GOC:mah]
is_a: GO:0032880 ! regulation of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045184 ! establishment of protein localization
relationship: regulates GO:0045184 ! establishment of protein localization

[Term]
id: GO:0070202
name: regulation of establishment of protein localization to chromosome
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location on a chromosome." [GOC:BHF, GOC:mah]
synonym: "regulation of establishment of protein localisation to chromosome" EXACT [GOC:mah]
is_a: GO:0070201 ! regulation of establishment of protein localization
is_a: GO:1903827 ! regulation of cellular protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070199 ! establishment of protein localization to chromosome
relationship: regulates GO:0070199 ! establishment of protein localization to chromosome

[Term]
id: GO:0070203
name: regulation of establishment of protein localization to telomere
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location in the telomeric region of a chromosome." [GOC:BHF, GOC:mah]
synonym: "regulation of establishment of protein localisation to telomere" EXACT [GOC:mah]
is_a: GO:0070202 ! regulation of establishment of protein localization to chromosome
is_a: GO:1904814 ! regulation of protein localization to chromosome, telomeric region
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070200 ! establishment of protein localization to telomere
relationship: regulates GO:0070200 ! establishment of protein localization to telomere

[Term]
id: GO:0070204
name: 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + H(+) + isochorismate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO(2)." [EC:2.2.1.9, RHEA:25596]
comment: Note that this function was formerly EC:4.1.3.18.
subset: gosubset_prok
synonym: "MenD" RELATED [EC:2.2.1.9]
synonym: "SEPHCHC synthase activity" EXACT [EC:2.2.1.9]
xref: EC:2.2.1.9
xref: KEGG:R08165
xref: MetaCyc:2.5.1.64-RXN
xref: RHEA:25596
is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups

[Term]
id: GO:0070205
name: 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate = (1R,6R)-2-succinyl-6-hydroxycyclohexa-2,4-diene-1-carboxylate + pyruvate." [EC:4.2.99.20, RHEA:25600]
synonym: "2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid synthase activity" EXACT [EC:4.2.99.20]
synonym: "6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate synthase activity" EXACT [EC:4.2.99.20]
synonym: "MenH" RELATED [EC:4.2.99.20]
synonym: "SHCHC synthase activity" EXACT [EC:4.2.99.20]
synonym: "YfbB" RELATED [EC:4.2.99.20]
xref: EC:4.2.99.20
xref: KEGG:R08166
xref: MetaCyc:RXN-9310
xref: RHEA:25600
is_a: GO:0016835 ! carbon-oxygen lyase activity

[Term]
id: GO:0070206
name: protein trimerization
namespace: biological_process
def: "The formation of a protein trimer, a macromolecular structure consisting of three noncovalently associated identical or nonidentical subunits." [GOC:hjd]
subset: gosubset_prok
synonym: "protein trimer assembly" EXACT [GOC:hjd]
synonym: "protein trimer biosynthesis" EXACT [GOC:hjd]
synonym: "protein trimer biosynthetic process" EXACT [GOC:hjd]
synonym: "protein trimer formation" EXACT [GOC:hjd]
is_a: GO:0051259 ! protein oligomerization

[Term]
id: GO:0070207
name: protein homotrimerization
namespace: biological_process
def: "The formation of a protein homotrimer, a macromolecular structure consisting of three noncovalently associated identical subunits." [GOC:hjd]
subset: gosubset_prok
synonym: "protein homotrimer assembly" EXACT [GOC:hjd]
synonym: "protein homotrimer biosynthesis" EXACT [GOC:hjd]
synonym: "protein homotrimer biosynthetic process" EXACT [GOC:hjd]
synonym: "protein homotrimer formation" EXACT [GOC:hjd]
is_a: GO:0051260 ! protein homooligomerization
is_a: GO:0070206 ! protein trimerization

[Term]
id: GO:0070208
name: protein heterotrimerization
namespace: biological_process
def: "The formation of a protein heterotrimer, a macromolecular structure consisting of three noncovalently associated subunits, of which not all are identical." [GOC:hjd]
subset: gosubset_prok
synonym: "protein heterotrimer assembly" EXACT [GOC:hjd]
synonym: "protein heterotrimer biosynthesis" EXACT [GOC:hjd]
synonym: "protein heterotrimer biosynthetic process" EXACT [GOC:hjd]
synonym: "protein heterotrimer formation" EXACT [GOC:hjd]
is_a: GO:0051291 ! protein heterooligomerization
is_a: GO:0070206 ! protein trimerization

[Term]
id: GO:0070209
name: ASTRA complex
namespace: cellular_component
def: "A protein complex that is part of the chromatin remodeling machinery; the acronym stands for ASsembly of Tel, Rvb and Atm-like kinase. In Saccharomyces cerevisiae this complex includes Rvb1p, Rvb2p, Tra1p, Tel2p, Asa1p, Ttilp and Tti2p." [GOC:rb, PMID:19040720]
is_a: GO:0000790 ! nuclear chromatin
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0070210
name: Rpd3L-Expanded complex
namespace: cellular_component
def: "A protein complex that contains a histone deacetylase and is part of the chromatin remodeling machinery. In Saccharomyces cerevisiae this complex contains the Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p, Ash1p, Dot6p, Snt1, Sif2p, Set3p, Hos2p, Tos4p and Tod6p proteins." [GOC:rb, PMID:19040720]
synonym: "Clr6-LE complex" EXACT [GOC:vw]
is_a: GO:0000118 ! histone deacetylase complex
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000790 ! nuclear chromatin

[Term]
id: GO:0070211
name: Snt2C complex
namespace: cellular_component
def: "A histone deacetylase complex that is part of the chromatin remodeling machinery. In Saccharomyces cerevisiae this complex contains Snt2p, Ecm5p and Rpd3p." [GOC:rb, PMID:19040720]
is_a: GO:0000118 ! histone deacetylase complex
is_a: GO:0000790 ! nuclear chromatin

[Term]
id: GO:0070212
name: protein poly-ADP-ribosylation
namespace: biological_process
def: "The transfer of multiple ADP-ribose residues from NAD to a protein amino acid, forming a poly(ADP-ribose) chain." [GOC:BHF, GOC:mah, GOC:rl]
synonym: "addition of poly-ADP-ribose to protein" EXACT [GOC:rl]
synonym: "poly(ADP-ribose) addition to protein" EXACT [GOC:rl]
synonym: "protein amino acid poly-ADP-ribosylation" EXACT [GOC:bf]
synonym: "protein poly(ADP-ribose) metabolism" RELATED [GOC:rl]
synonym: "protein poly(ADP-ribose) synthesis" EXACT [GOC:rl]
is_a: GO:0006471 ! protein ADP-ribosylation

[Term]
id: GO:0070213
name: protein auto-ADP-ribosylation
namespace: biological_process
def: "The ADP-ribosylation by a protein of one or more of its own amino acid residues, or residues on an identical protein." [GOC:BHF, GOC:rl]
synonym: "protein amino acid auto-ADP-ribosylation" EXACT [GOC:bf]
is_a: GO:0006471 ! protein ADP-ribosylation

[Term]
id: GO:0070214
name: CSK-GAP-A.p62 complex
namespace: cellular_component
def: "A protein complex that contains the protein-tyrosine kinase CSK and the GTPase-activating protein (GAP)-associated p62 (GAP-A.p62); may mediate translocation of proteins, including GAP and CSK, to membrane or cytoskeletal regions upon c-Src activation." [PMID:7544435]
comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0031252 ! cell leading edge

[Term]
id: GO:0070215
name: obsolete MDM2 binding
namespace: molecular_function
def: "OBSOLETE. Interacting selectively and non-covalently with any isoform of the MDM2 protein, a negative regulator of p53." [GOC:mah, GOC:nln]
comment: This term was made obsolete because it represents binding to an individual protein.
synonym: "MDM2 binding" EXACT []
is_obsolete: true
replaced_by: GO:0097371

[Term]
id: GO:0070216
name: obsolete MDM4 binding
namespace: molecular_function
def: "OBSOLETE. Interacting selectively and non-covalently with any isoform of the MDM4 protein, a negative regulator of p53." [GOC:mah, GOC:nln]
comment: This term was made obsolete because it represents binding to an individual protein.
synonym: "MDM4 binding" EXACT []
synonym: "MDMX binding" EXACT [GOC:nln]
is_obsolete: true
replaced_by: GO:0097371

[Term]
id: GO:0070217
name: transcription factor TFIIIB complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a transcription factor TFIIIB complex." [GOC:mah]
synonym: "TFIIIB assembly" EXACT [GOC:mah]
is_a: GO:0043623 ! cellular protein complex assembly

[Term]
id: GO:0070218
name: sulfide ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of sulfide ions within an organism or cell." [GOC:mah]
synonym: "sulfide generation" RELATED [GOC:mah]
synonym: "sulfide homeostasis" EXACT [GOC:mah]
synonym: "sulfide production" RELATED [GOC:mah]
synonym: "sulphide generation" RELATED [GOC:mah]
synonym: "sulphide homeostasis" EXACT [GOC:mah]
synonym: "sulphide ion homeostasis" EXACT [GOC:mah]
synonym: "sulphide production" RELATED [GOC:mah]
is_a: GO:0055083 ! monovalent inorganic anion homeostasis
is_a: GO:0072505 ! divalent inorganic anion homeostasis

[Term]
id: GO:0070219
name: cellular sulfide ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of sulfide ions at the level of a cell." [GOC:mah]
synonym: "cellular sulfide homeostasis" EXACT [GOC:mah]
synonym: "cellular sulphide homeostasis" EXACT [GOC:mah]
synonym: "cellular sulphide ion homeostasis" EXACT [GOC:mah]
is_a: GO:0030320 ! cellular monovalent inorganic anion homeostasis
is_a: GO:0070218 ! sulfide ion homeostasis
is_a: GO:0072501 ! cellular divalent inorganic anion homeostasis

[Term]
id: GO:0070220
name: aerobic sulfur oxidation
namespace: biological_process
def: "A sulfur oxidation process that proceeds via the reaction catalyzed by sulfur dioxygenase, and requires the presence of oxygen." [MetaCyc:SULFUROX-PWY]
subset: gosubset_prok
synonym: "aerobic sulphur oxidation" EXACT [GOC:mah]
xref: MetaCyc:SULFUROX-PWY
is_a: GO:0019417 ! sulfur oxidation

[Term]
id: GO:0070221
name: sulfide oxidation, using sulfide:quinone oxidoreductase
namespace: biological_process
def: "A sulfide oxidation process that proceeds via the reaction catalyzed by sulfide:quinone oxidoreductase." [MetaCyc:P222-PWY]
subset: gosubset_prok
synonym: "sulfide oxidation, using sulfide-quinone reductase" EXACT [GOC:mah, MetaCyc:P222-PWY]
synonym: "sulphide oxidation, using sulfide:quinone oxidoreductase" EXACT [GOC:mah]
xref: MetaCyc:P222-PWY
xref: Reactome:REACT_116010 "Sulfide oxidation to sulfate, Homo sapiens"
is_a: GO:0019418 ! sulfide oxidation

[Term]
id: GO:0070222
name: sulfide oxidation, using sulfide dehydrogenase
namespace: biological_process
def: "A sulfide oxidation process that proceeds via the reaction catalyzed by sulfide dehydrogenase." [MetaCyc:PWY-5274]
subset: gosubset_prok
synonym: "sulphide oxidation, using sulfide dehydrogenase" EXACT [GOC:mah]
xref: MetaCyc:PWY-5274
is_a: GO:0019418 ! sulfide oxidation

[Term]
id: GO:0070223
name: sulfide oxidation, using sulfur dioxygenase
namespace: biological_process
def: "A sulfide oxidation process that proceeds via the reaction catalyzed by sulfur dioxygenase." [MetaCyc:PWY-5285]
subset: gosubset_prok
synonym: "sulphide oxidation, using sulfur dioxygenase" EXACT [GOC:mah]
xref: MetaCyc:PWY-5285
is_a: GO:0019418 ! sulfide oxidation

[Term]
id: GO:0070224
name: sulfide:quinone oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrogen sulfide + a quinone = S0 + a hydroquinone." [MetaCyc:R17-RXN]
subset: gosubset_prok
synonym: "sulfide-quinone reductase activity" EXACT [MetaCyc:MONOMER-12314]
synonym: "sulphide:quinone oxidoreductase activity" EXACT [GOC:mah]
xref: EC:1.8.5.-
xref: MetaCyc:R17-RXN
xref: Reactome:REACT_115885 "SQR oxidizes sulfide to bound persulfide, Homo sapiens"
is_a: GO:0016672 ! oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor

[Term]
id: GO:0070225
name: sulfide dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrogen sulfide + oxidized cytochrome c = S0 + reduced cytochrome c." [MetaCyc:RXN-8156]
subset: gosubset_prok
synonym: "flavocytochrome c sulfide dehydrogenase activity" EXACT [MetaCyc:RXN-8156]
synonym: "sulphide dehydrogenase activity" EXACT [GOC:mah]
xref: EC:1.8.2.-
xref: MetaCyc:RXN-8156
is_a: GO:0016669 ! oxidoreductase activity, acting on a sulfur group of donors, cytochrome as acceptor

[Term]
id: GO:0070226
name: sulfur:ferric ion oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: a perthiol + 4 Fe3+ + 3 H2O = sulfite + a thiol + 4 Fe2+ + 8 H+." [MetaCyc:SULFFEOXIDO-RXN]
subset: gosubset_prok
synonym: "hydrogen sulfide:ferric ion oxidoreductase" EXACT [MetaCyc:SULFFEOXIDO-RXN]
xref: MetaCyc:SULFFEOXIDO-RXN
is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors

[Term]
id: GO:0070227
name: lymphocyte apoptotic process
namespace: biological_process
def: "Any apoptotic process in a lymphocyte, a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin." [CL:0000542, GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542).
synonym: "lymphocyte apoptosis" NARROW []
is_a: GO:0071887 ! leukocyte apoptotic process

[Term]
id: GO:0070228
name: regulation of lymphocyte apoptotic process
namespace: biological_process
def: "Any process that modulates the occurrence or rate of lymphocyte death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542).
synonym: "regulation of lymphocyte apoptosis" NARROW []
is_a: GO:2000106 ! regulation of leukocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070227 ! lymphocyte apoptotic process
relationship: regulates GO:0070227 ! lymphocyte apoptotic process

[Term]
id: GO:0070229
name: negative regulation of lymphocyte apoptotic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542).
synonym: "down regulation of lymphocyte apoptosis" EXACT [GOC:add]
synonym: "down-regulation of lymphocyte apoptosis" EXACT [GOC:add]
synonym: "downregulation of lymphocyte apoptosis" EXACT [GOC:add]
synonym: "inhibition of lymphocyte apoptosis" NARROW [GOC:add]
synonym: "negative regulation of lymphocyte apoptosis" NARROW []
is_a: GO:0070228 ! regulation of lymphocyte apoptotic process
is_a: GO:2000107 ! negative regulation of leukocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070227 ! lymphocyte apoptotic process
relationship: negatively_regulates GO:0070227 ! lymphocyte apoptotic process

[Term]
id: GO:0070230
name: positive regulation of lymphocyte apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lymphocyte death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542).
synonym: "activation of lymphocyte apoptosis" NARROW [GOC:add]
synonym: "positive regulation of lymphocyte apoptosis" NARROW []
synonym: "stimulation of lymphocyte apoptosis" NARROW [GOC:add]
synonym: "up regulation of lymphocyte apoptosis" EXACT [GOC:add]
synonym: "up-regulation of lymphocyte apoptosis" EXACT [GOC:add]
synonym: "upregulation of lymphocyte apoptosis" EXACT [GOC:add]
is_a: GO:0070228 ! regulation of lymphocyte apoptotic process
is_a: GO:2000108 ! positive regulation of leukocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070227 ! lymphocyte apoptotic process
relationship: positively_regulates GO:0070227 ! lymphocyte apoptotic process

[Term]
id: GO:0070231
name: T cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a T cell, a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex." [CL:0000084, GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
synonym: "programmed cell death of T cells by apoptosis" EXACT [GOC:add]
synonym: "T cell apoptosis" NARROW []
synonym: "T lymphocyte apoptosis" EXACT [GOC:add]
synonym: "T-cell apoptosis" EXACT [GOC:add]
synonym: "T-lymphocyte apoptosis" EXACT [GOC:add]
is_a: GO:0070227 ! lymphocyte apoptotic process

[Term]
id: GO:0070232
name: regulation of T cell apoptotic process
namespace: biological_process
def: "Any process that modulates the occurrence or rate of T cell death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
synonym: "regulation of programmed cell death of T cells by apoptosis" EXACT [GOC:add]
synonym: "regulation of T cell apoptosis" NARROW []
synonym: "regulation of T lymphocyte apoptosis" EXACT [GOC:add]
synonym: "regulation of T-cell apoptosis" EXACT [GOC:add]
synonym: "regulation of T-lymphocyte apoptosis" EXACT [GOC:add]
is_a: GO:0070228 ! regulation of lymphocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070231 ! T cell apoptotic process
relationship: regulates GO:0070231 ! T cell apoptotic process

[Term]
id: GO:0070233
name: negative regulation of T cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
synonym: "down regulation of T cell apoptosis" EXACT [GOC:add]
synonym: "down-regulation of T cell apoptosis" EXACT [GOC:add]
synonym: "downregulation of T cell apoptosis" EXACT [GOC:add]
synonym: "inhibition of T cell apoptosis" NARROW [GOC:add]
synonym: "negative regulation of programmed cell death of T cells by apoptosis" EXACT [GOC:add]
synonym: "negative regulation of T cell apoptosis" NARROW []
synonym: "negative regulation of T lymphocyte apoptosis" EXACT [GOC:add]
synonym: "negative regulation of T-cell apoptosis" EXACT [GOC:add]
synonym: "negative regulation of T-lymphocyte apoptosis" EXACT [GOC:add]
is_a: GO:0070229 ! negative regulation of lymphocyte apoptotic process
is_a: GO:0070232 ! regulation of T cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070231 ! T cell apoptotic process
relationship: negatively_regulates GO:0070231 ! T cell apoptotic process

[Term]
id: GO:0070234
name: positive regulation of T cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T cell death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
synonym: "activation of T cell apoptosis" NARROW [GOC:add]
synonym: "positive regulation of programmed cell death of T cells by apoptosis" EXACT [GOC:add]
synonym: "positive regulation of T cell apoptosis" NARROW []
synonym: "positive regulation of T lymphocyte apoptosis" EXACT [GOC:add]
synonym: "positive regulation of T-cell apoptosis" EXACT [GOC:add]
synonym: "positive regulation of T-lymphocyte apoptosis" EXACT [GOC:add]
synonym: "stimulation of T cell apoptosis" NARROW [GOC:add]
synonym: "up regulation of T cell apoptosis" EXACT [GOC:add]
synonym: "up-regulation of T cell apoptosis" EXACT [GOC:add]
synonym: "upregulation of T cell apoptosis" EXACT [GOC:add]
is_a: GO:0070230 ! positive regulation of lymphocyte apoptotic process
is_a: GO:0070232 ! regulation of T cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070231 ! T cell apoptotic process
relationship: positively_regulates GO:0070231 ! T cell apoptotic process

[Term]
id: GO:0070235
name: regulation of activation-induced cell death of T cells
namespace: biological_process
def: "Any process that modulates the occurrence or rate of activation-induced cell death of T cells." [GOC:add, ISBN:0781765196]
synonym: "regulation of activated T cell apoptosis" BROAD [GOC:add]
synonym: "regulation of activation-induced cell death of T lymphocytes" EXACT [GOC:add]
synonym: "regulation of activation-induced cell death of T-cells" EXACT [GOC:add]
synonym: "regulation of activation-induced cell death of T-lymphocytes" EXACT [GOC:add]
synonym: "regulation of AICD" BROAD [GOC:add]
synonym: "regulation of antigen-driven apoptosis" BROAD [GOC:add]
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0032844 ! regulation of homeostatic process
is_a: GO:0070232 ! regulation of T cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006924 ! activation-induced cell death of T cells
relationship: regulates GO:0006924 ! activation-induced cell death of T cells

[Term]
id: GO:0070236
name: negative regulation of activation-induced cell death of T cells
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of activation-induced cell death of T cells." [GOC:add, ISBN:0781765196]
synonym: "down regulation of activation-induced cell death of T cells" EXACT [GOC:add]
synonym: "down-regulation of activation-induced cell death of T cells" EXACT [GOC:add]
synonym: "downregulation of activation-induced cell death of T cells" EXACT [GOC:add]
synonym: "inhibition of activation-induced cell death of T cells" NARROW [GOC:add]
synonym: "negative regulation of activated T cell apoptosis" BROAD [GOC:add]
synonym: "negative regulation of activation-induced cell death of T lymphocytes" EXACT [GOC:add]
synonym: "negative regulation of activation-induced cell death of T-cells" EXACT [GOC:add]
synonym: "negative regulation of activation-induced cell death of T-lymphocytes" EXACT [GOC:add]
synonym: "negative regulation of AICD" BROAD [GOC:add]
synonym: "negative regulation of antigen-driven apoptosis" BROAD []
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0032845 ! negative regulation of homeostatic process
is_a: GO:0070233 ! negative regulation of T cell apoptotic process
is_a: GO:0070235 ! regulation of activation-induced cell death of T cells
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006924 ! activation-induced cell death of T cells
relationship: negatively_regulates GO:0006924 ! activation-induced cell death of T cells

[Term]
id: GO:0070237
name: positive regulation of activation-induced cell death of T cells
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of activation-induced cell death of T cells." [GOC:add, ISBN:0781765196]
synonym: "activation of activation-induced cell death of T cells" NARROW [GOC:add]
synonym: "positive regulation of activated T cell apoptosis" BROAD [GOC:add]
synonym: "positive regulation of activation-induced cell death of T lymphocytes" EXACT [GOC:add]
synonym: "positive regulation of activation-induced cell death of T-cells" EXACT [GOC:add]
synonym: "positive regulation of activation-induced cell death of T-lymphocytes" EXACT [GOC:add]
synonym: "positive regulation of AICD" BROAD [GOC:add]
synonym: "positive regulation of antigen-driven apoptosis" BROAD [GOC:add]
synonym: "stimulation of activation-induced cell death of T cells" NARROW [GOC:add]
synonym: "up regulation of activation-induced cell death of T cells" EXACT [GOC:add]
synonym: "up-regulation of activation-induced cell death of T cells" EXACT [GOC:add]
synonym: "upregulation of activation-induced cell death of T cells" EXACT [GOC:add]
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0032846 ! positive regulation of homeostatic process
is_a: GO:0070234 ! positive regulation of T cell apoptotic process
is_a: GO:0070235 ! regulation of activation-induced cell death of T cells
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006924 ! activation-induced cell death of T cells
relationship: positively_regulates GO:0006924 ! activation-induced cell death of T cells

[Term]
id: GO:0070238
name: activated T cell autonomous cell death
namespace: biological_process
def: "A T cell apoptotic process that occurs towards the end of the expansion phase following the initial activation of mature T cells by antigen via the accumulation of pro-apoptotic gene products and decrease in anti-apoptotic gene products." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
synonym: "ACAD" BROAD [GOC:add]
synonym: "activated cell autonomous cell death" BROAD [GOC:add]
synonym: "activated T cell apoptosis" BROAD [GOC:add]
synonym: "activated T lymphocyte autonomous cell death" EXACT [GOC:add]
synonym: "activated T-cell autonomous cell death" EXACT [GOC:add]
synonym: "activated T-lymphocyte autonomous cell death" EXACT [GOC:add]
is_a: GO:0070231 ! T cell apoptotic process
relationship: part_of GO:0043029 ! T cell homeostasis

[Term]
id: GO:0070239
name: regulation of activated T cell autonomous cell death
namespace: biological_process
def: "Any process that modulates the occurrence or rate of activated T cell autonomous cell death." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
synonym: "regulation of ACAD" BROAD [GOC:add]
synonym: "regulation of activated cell autonomous cell death" BROAD [GOC:add]
synonym: "regulation of activated T cell apoptosis" BROAD [GOC:add]
synonym: "regulation of activated T lymphocyte autonomous cell death" EXACT [GOC:add]
synonym: "regulation of activated T-cell autonomous cell death" EXACT [GOC:add]
synonym: "regulation of activated T-lymphocyte autonomous cell death" EXACT [GOC:add]
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0032844 ! regulation of homeostatic process
is_a: GO:0070232 ! regulation of T cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070238 ! activated T cell autonomous cell death
relationship: regulates GO:0070238 ! activated T cell autonomous cell death

[Term]
id: GO:0070240
name: negative regulation of activated T cell autonomous cell death
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of activated T cell autonomous cell death." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
synonym: "down regulation of activated T cell autonomous cell death" EXACT [GOC:add]
synonym: "down-regulation of activated T cell autonomous cell death" EXACT [GOC:add]
synonym: "downregulation of activated T cell autonomous cell death" EXACT [GOC:add]
synonym: "inhibition of activated T cell autonomous cell death" NARROW [GOC:add]
synonym: "negative regulation of ACAD" BROAD [GOC:add]
synonym: "negative regulation of activated cell autonomous cell death" BROAD [GOC:add]
synonym: "negative regulation of activated T cell apoptosis" BROAD [GOC:add]
synonym: "negative regulation of activated T lymphocyte autonomous cell death" EXACT [GOC:add]
synonym: "negative regulation of activated T-cell autonomous cell death" EXACT [GOC:add]
synonym: "negative regulation of activated T-lymphocyte autonomous cell death" EXACT [GOC:add]
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0032845 ! negative regulation of homeostatic process
is_a: GO:0070233 ! negative regulation of T cell apoptotic process
is_a: GO:0070239 ! regulation of activated T cell autonomous cell death
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070238 ! activated T cell autonomous cell death
relationship: negatively_regulates GO:0070238 ! activated T cell autonomous cell death

[Term]
id: GO:0070241
name: positive regulation of activated T cell autonomous cell death
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of activated T cell autonomous cell death." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
synonym: "activation of activated T cell autonomous cell death" NARROW [GOC:add]
synonym: "positive regulation of ACAD" BROAD [GOC:add]
synonym: "positive regulation of activated cell autonomous cell death" BROAD [GOC:add]
synonym: "positive regulation of activated T cell apoptosis" BROAD [GOC:add]
synonym: "positive regulation of activated T lymphocyte autonomous cell death" EXACT [GOC:add]
synonym: "positive regulation of activated T-cell autonomous cell death" EXACT [GOC:add]
synonym: "positive regulation of activated T-lymphocyte autonomous cell death" EXACT [GOC:add]
synonym: "stimulation of activated T cell autonomous cell death" NARROW [GOC:add]
synonym: "up regulation of activated T cell autonomous cell death" EXACT [GOC:add]
synonym: "up-regulation of activated T cell autonomous cell death" EXACT [GOC:add]
synonym: "upregulation of activated T cell autonomous cell death" EXACT [GOC:add]
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0032846 ! positive regulation of homeostatic process
is_a: GO:0070234 ! positive regulation of T cell apoptotic process
is_a: GO:0070239 ! regulation of activated T cell autonomous cell death
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070238 ! activated T cell autonomous cell death
relationship: positively_regulates GO:0070238 ! activated T cell autonomous cell death

[Term]
id: GO:0070242
name: thymocyte apoptotic process
namespace: biological_process
def: "Any apoptotic process in a thymocyte, an immature T cell located in the thymus." [CL:0000893, GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
comment: Note that a thymocyte is an immature T cell located in the thymus (CL:0000893).
synonym: "immature T cell apoptosis" RELATED [GOC:add]
synonym: "thymocyte apoptosis" NARROW []
is_a: GO:0070231 ! T cell apoptotic process

[Term]
id: GO:0070243
name: regulation of thymocyte apoptotic process
namespace: biological_process
def: "Any process that modulates the occurrence or rate of thymocyte death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
comment: Note that a thymocyte is an immature T cell located in the thymus (CL:0000893).
synonym: "regulation of immature T cell apoptosis" RELATED [GOC:add]
synonym: "regulation of thymocyte apoptosis" NARROW []
is_a: GO:0070232 ! regulation of T cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070242 ! thymocyte apoptotic process
relationship: regulates GO:0070242 ! thymocyte apoptotic process

[Term]
id: GO:0070244
name: negative regulation of thymocyte apoptotic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of thymocyte death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
comment: Note that a thymocyte is an immature T cell located in the thymus (CL:0000893).
synonym: "down regulation of thymocyte apoptosis" EXACT [GOC:add]
synonym: "down-regulation of thymocyte apoptosis" EXACT [GOC:add]
synonym: "downregulation of thymocyte apoptosis" EXACT [GOC:add]
synonym: "inhibition of thymocyte apoptosis" NARROW [GOC:add]
synonym: "negative regulation of immature T cell apoptosis" RELATED [GOC:add]
synonym: "negative regulation of thymocyte apoptosis" NARROW []
is_a: GO:0070233 ! negative regulation of T cell apoptotic process
is_a: GO:0070243 ! regulation of thymocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070242 ! thymocyte apoptotic process
relationship: negatively_regulates GO:0070242 ! thymocyte apoptotic process

[Term]
id: GO:0070245
name: positive regulation of thymocyte apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of thymocyte death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
comment: Note that a thymocyte is an immature T cell located in the thymus (CL:0000893).
synonym: "activation of thymocyte apoptosis" NARROW [GOC:add]
synonym: "positive regulation of immature T cell apoptosis" RELATED [GOC:add]
synonym: "positive regulation of thymocyte apoptosis" NARROW []
synonym: "stimulation of thymocyte apoptosis" NARROW [GOC:add]
synonym: "up regulation of thymocyte apoptosis" EXACT [GOC:add]
synonym: "up-regulation of thymocyte apoptosis" EXACT [GOC:add]
synonym: "upregulation of thymocyte apoptosis" EXACT [GOC:add]
is_a: GO:0070234 ! positive regulation of T cell apoptotic process
is_a: GO:0070243 ! regulation of thymocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070242 ! thymocyte apoptotic process
relationship: positively_regulates GO:0070242 ! thymocyte apoptotic process

[Term]
id: GO:0070246
name: natural killer cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a natural killer cell, a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation." [CL:0000623, GOC:add, GOC:mtg_apoptosis, PMID:15728472]
synonym: "natural killer cell apoptosis" NARROW []
synonym: "NK cell apoptosis" EXACT [GOC:add]
is_a: GO:0070227 ! lymphocyte apoptotic process

[Term]
id: GO:0070247
name: regulation of natural killer cell apoptotic process
namespace: biological_process
def: "Any process that modulates the occurrence or rate of natural killer cell death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
synonym: "regulation of natural killer cell apoptosis" NARROW []
synonym: "regulation of NK cell apoptosis" EXACT [GOC:add]
is_a: GO:0070228 ! regulation of lymphocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070246 ! natural killer cell apoptotic process
relationship: regulates GO:0070246 ! natural killer cell apoptotic process

[Term]
id: GO:0070248
name: negative regulation of natural killer cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
synonym: "down regulation of natural killer cell apoptosis" EXACT [GOC:add]
synonym: "down-regulation of natural killer cell apoptosis" EXACT [GOC:add]
synonym: "downregulation of natural killer cell apoptosis" EXACT [GOC:add]
synonym: "inhibition of natural killer cell apoptosis" NARROW [GOC:add]
synonym: "negative regulation of natural killer cell apoptosis" NARROW []
synonym: "negative regulation of NK cell apoptosis" EXACT [GOC:add]
is_a: GO:0070229 ! negative regulation of lymphocyte apoptotic process
is_a: GO:0070247 ! regulation of natural killer cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070246 ! natural killer cell apoptotic process
relationship: negatively_regulates GO:0070246 ! natural killer cell apoptotic process

[Term]
id: GO:0070249
name: positive regulation of natural killer cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of natural killer cell death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
synonym: "activation of natural killer cell apoptosis" NARROW [GOC:add]
synonym: "positive regulation of natural killer cell apoptosis" NARROW []
synonym: "positive regulation of NK cell apoptosis" EXACT [GOC:add]
synonym: "stimulation of natural killer cell apoptosis" NARROW [GOC:add]
synonym: "up regulation of natural killer cell apoptosis" EXACT [GOC:add]
synonym: "up-regulation of natural killer cell apoptosis" EXACT [GOC:add]
synonym: "upregulation of natural killer cell apoptosis" EXACT [GOC:add]
is_a: GO:0070230 ! positive regulation of lymphocyte apoptotic process
is_a: GO:0070247 ! regulation of natural killer cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070246 ! natural killer cell apoptotic process
relationship: positively_regulates GO:0070246 ! natural killer cell apoptotic process

[Term]
id: GO:0070250
name: mating projection membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a mating projection, the projection formed by unicellular fungi in response to mating pheromone." [GOC:jp]
synonym: "shmoo membrane" NARROW [GOC:jp]
is_a: GO:0031253 ! cell projection membrane
relationship: part_of GO:0005937 ! mating projection

[Term]
id: GO:0070251
name: pristanate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + pristanate + CoA = AMP + diphosphate + pristanoyl-CoA." [GOC:pde, PMID:10198260]
subset: gosubset_prok
synonym: "pristanate:CoA ligase (AMP-forming)" EXACT [GOC:mah]
synonym: "pristanoyl-CoA ligase activity" EXACT [GOC:mah]
xref: EC:6.2.1.-
xref: Reactome:REACT_100261 "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate, Xenopus tropicalis"
xref: Reactome:REACT_112851 "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate, Taeniopygia guttata"
xref: Reactome:REACT_113004 "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_17058 "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate, Homo sapiens"
xref: Reactome:REACT_31554 "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate, Danio rerio"
xref: Reactome:REACT_33059 "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate, Mycobacterium tuberculosis"
xref: Reactome:REACT_77398 "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate, Mus musculus"
xref: Reactome:REACT_77724 "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate, Rattus norvegicus"
xref: Reactome:REACT_83966 "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate, Sus scrofa"
xref: Reactome:REACT_86288 "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate, Canis familiaris"
xref: Reactome:REACT_86956 "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate, Bos taurus"
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0070252
name: actin-mediated cell contraction
namespace: biological_process
def: "The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of all or part of the cell body." [GOC:mah]
is_a: GO:0030048 ! actin filament-based movement

[Term]
id: GO:0070253
name: somatostatin secretion
namespace: biological_process
def: "The regulated release of somatostatin from secretory granules in the D cells of the pancreas." [GOC:mah]
is_a: GO:0030072 ! peptide hormone secretion

[Term]
id: GO:0070254
name: mucus secretion
namespace: biological_process
def: "The regulated release of mucus by the mucosa. Mucus is a viscous slimy secretion consisting of mucins and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes. The mucosa, or mucous membrane, is the membrane covered with epithelium that lines the tubular organs of the body. Mucins are carbohydrate-rich glycoproteins that have a lubricating and protective function." [GOC:add, ISBN:068340007X, ISBN:0721662544]
synonym: "mucus production" EXACT [GOC:add]
is_a: GO:0007589 ! body fluid secretion
is_a: GO:0032941 ! secretion by tissue

[Term]
id: GO:0070255
name: regulation of mucus secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of mucus from a cell or a tissue." [GOC:add]
synonym: "regulation of mucus production" EXACT [GOC:add]
is_a: GO:0050878 ! regulation of body fluid levels
is_a: GO:0051046 ! regulation of secretion
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070254 ! mucus secretion
relationship: regulates GO:0070254 ! mucus secretion

[Term]
id: GO:0070256
name: negative regulation of mucus secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of mucus from a cell or a tissue." [GOC:add]
synonym: "negative regulation of mucus production" EXACT [GOC:add]
is_a: GO:0051048 ! negative regulation of secretion
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0070255 ! regulation of mucus secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070254 ! mucus secretion
relationship: negatively_regulates GO:0070254 ! mucus secretion

[Term]
id: GO:0070257
name: positive regulation of mucus secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of mucus from a cell or a tissue." [GOC:add]
synonym: "positive regulation of mucus production" EXACT [GOC:add]
is_a: GO:0051047 ! positive regulation of secretion
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0070255 ! regulation of mucus secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070254 ! mucus secretion
relationship: positively_regulates GO:0070254 ! mucus secretion

[Term]
id: GO:0070258
name: inner membrane complex
namespace: cellular_component
def: "A membrane structure formed of two closely aligned lipid bilayers that lie beneath the plasma membrane and form part of the pellicle surrounding an apicomplexan parasite cell." [GOC:mah, PMID:12456714]
is_a: GO:0044464 ! cell part
relationship: part_of GO:0020039 ! pellicle

[Term]
id: GO:0070259
name: tyrosyl-DNA phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between a DNA topoisomerase and DNA." [GOC:elh, PMID:16751265]
comment: See also the molecular function term 'DNA topoisomerase type I activity ; GO:0003917'.
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0070260
name: 5'-tyrosyl-DNA phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of 5'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase II and DNA." [PMID:16751265]
comment: See also the molecular function term 'DNA topoisomerase type I activity ; GO:0003917'.
is_a: GO:0070259 ! tyrosyl-DNA phosphodiesterase activity

[Term]
id: GO:0070262
name: peptidyl-serine dephosphorylation
namespace: biological_process
def: "The removal of phosphoric residues from peptidyl-O-phospho-L-serine to form peptidyl-serine." [GOC:bf]
is_a: GO:0006470 ! protein dephosphorylation

[Term]
id: GO:0070263
name: external side of fungal-type cell wall
namespace: cellular_component
def: "The side of the fungal-type cell wall that is opposite to the side that faces the cell and its contents." [GOC:mah]
is_a: GO:0010339 ! external side of cell wall
relationship: part_of GO:0009277 ! fungal-type cell wall

[Term]
id: GO:0070264
name: transcription factor TFIIIE complex
namespace: cellular_component
def: "A transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIE contains a specific subset of ribosomal proteins." [GOC:jp, PMID:19116144]
is_a: GO:0044451 ! nucleoplasm part
is_a: GO:0090576 ! RNA polymerase III transcription factor complex
relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme

[Term]
id: GO:0070265
name: necrotic cell death
namespace: biological_process
def: "A type of cell death that is morphologically characterized by an increasingly translucent cytoplasm, swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. Necrotic cells do not fragment into discrete corpses as their apoptotic counterparts do. Moreover, their nuclei remain intact and can aggregate and accumulate in necrotic tissues." [GOC:mtg_apoptosis, PMID:18846107, PMID:20823910]
comment: Note that the word necrosis has been widely used in earlier literature to describe forms of cell death which are now known by more precise terms, such as apoptosis. Necrosis can occur in a regulated fashion, involving a precise sequence of signals; in this case, consider annotating to GO:0097300 'programmed necrotic cell death' or to its more specific child GO:0070266 'necroptotic process'.
synonym: "cellular necrosis" EXACT [GOC:add]
synonym: "necrosis" BROAD [GOC:mah]
is_a: GO:0008219 ! cell death

[Term]
id: GO:0070266
name: necroptotic process
namespace: biological_process
alt_id: GO:0060553
alt_id: GO:0060554
alt_id: GO:0060555
def: "A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3) and by critical dependence on mixed lineage kinase domain-like (MLKL), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former." [GOC:BHF, GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, PMID:18846107, PMID:20823910, PMID:21737330, PMID:21760595, PMID:21876153]
comment: Examples of this are Birc2 and Birc3 (UniProt symbols Q62210 and O08863) in PMID:21052097.
synonym: "activation of necroptosis" RELATED []
synonym: "activation of necroptosis by extracellular signals" RELATED []
synonym: "activation of necroptosis in response to extracellular signals" RELATED []
synonym: "activation of necroptosis of activated-T cells" RELATED []
synonym: "establishment of necroptosis" RELATED []
synonym: "establishment of necroptosis of activated-T cells" RELATED []
synonym: "extracellular signal-induced necroptosis" RELATED []
synonym: "induction of necroptosis" BROAD []
synonym: "induction of necroptosis by extracellular signals" BROAD []
synonym: "induction of necroptosis of activated-T cells" BROAD []
synonym: "necroptosis" NARROW []
synonym: "PARP-dependent cell death" RELATED []
synonym: "parthanatos" RELATED []
synonym: "programmed necrotic cell death" BROAD [GOC:mah]
synonym: "TNF-induced necroptosis" NARROW [PMID:21876153]
is_a: GO:0097300 ! programmed necrotic cell death

[Term]
id: GO:0070267
name: oncosis
namespace: biological_process
def: "A cellular process that results in swelling of the cell body, and that is morphologically characteristic of necrotic cell death." [PMID:17873035, PMID:18846107]
comment: Note that oncosis is sometimes described as a type of cell death, but recent nomenclature recommendations define it as a feature of necrotic cell death rather than a distinct mode of cell death.
is_a: GO:0045793 ! positive regulation of cell size
relationship: part_of GO:0070265 ! necrotic cell death

[Term]
id: GO:0070268
name: cornification
namespace: biological_process
def: "A type of programmed cell death that occurs in the epidermis, morphologically and biochemically distinct from apoptosis. It leads to the formation of corneocytes, i.e. dead keratinocytes containing an amalgam of specific proteins (e.g., keratin, loricrin, SPR and involucrin) and lipids (e.g., fatty acids and ceramides), which are necessary for the function of the cornified skin layer (mechanical resistance, elasticity, water repellence and structural stability)." [GOC:krc, PMID:18846107]
is_a: GO:0012501 ! programmed cell death
relationship: has_part GO:1903575 ! cornified envelope assembly
relationship: part_of GO:0031424 ! keratinization

[Term]
id: GO:0070269
name: pyroptosis
namespace: biological_process
def: "A caspase-1-dependent cell death subroutine that is associated with the generation of pyrogenic mediators such as IL-1beta and IL-18." [GOC:mtg_apoptosis, PMID:18846107, PMID:21760595]
is_a: GO:0012501 ! programmed cell death

[Term]
id: GO:0070270
name: obsolete mitotic catastrophe
namespace: biological_process
def: "OBSOLETE. A type of programmed cell death that occurs during or shortly after a dysregulated or failed mitosis and can be accompanied by morphological alterations including micronucleation and multinucleation." [PMID:18846107]
comment: This term was made obsolete because it does not refer to a true process, but rather to the consequences of aberrations occurred during mitosis.
synonym: "cell death occurring during metaphase" RELATED [PMID:18846107]
synonym: "cell death preceded by multinucleation" RELATED [PMID:18846107]
synonym: "mitotic catastrophe" EXACT []
is_obsolete: true

[Term]
id: GO:0070271
name: protein complex biogenesis
namespace: biological_process
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a protein complex. Includes the synthesis of non-protein components, and those protein modifications that are involved in synthesis or assembly of the complex." [GOC:mah]
comment: This classification should should only be used for complexes where synthesis of some non-protein component is necessary for assembly.
subset: goslim_yeast
subset: gosubset_prok
synonym: "protein complex biogenesis and assembly" EXACT [GOC:mah]
is_a: GO:0044085 ! cellular component biogenesis

[Term]
id: GO:0070272
name: proton-transporting ATP synthase complex biogenesis
namespace: biological_process
def: "The biogenesis of a proton-transporting ATP synthase (also known as F-type ATPase), a two-sector ATPase found in the inner membrane of mitochondria and chloroplasts, and in bacterial plasma membranes. Includes the synthesis of constituent proteins and their aggregation, arrangement and bonding together." [GOC:mah, PMID:19103153]
synonym: "F-type ATPase complex biogenesis" EXACT [GOC:mah]
is_a: GO:0070271 ! protein complex biogenesis

[Term]
id: GO:0070273
name: phosphatidylinositol-4-phosphate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position." [GOC:bf, GOC:mah]
is_a: GO:1901981 ! phosphatidylinositol phosphate binding

[Term]
id: GO:0070274
name: RES complex
namespace: cellular_component
def: "A protein complex that is required for efficient splicing, and prevents leakage of unspliced pre-mRNAs from the nucleus (named for pre-mRNA REtention and Splicing). In Saccharomyces, the complex consists of Ist3p, Bud13p, and Pml1p." [PMID:15565172, PMID:18809678, PMID:19010333, PMID:19033360]
synonym: "pre-mRNA retention and splicing complex" EXACT [GOC:sre]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0070275
name: aerobic ammonia oxidation to nitrite via pyruvic oxime
namespace: biological_process
def: "The metabolic process in which ammonia (NH3) is oxidized to nitrite (NO2) in the presence of oxygen. Hydroxylamine is produced enzymatically, and, in the presence of pyruvate, forms pyruvic oxime in a spontaneous, non-enzymatic reaction; pyruvic oxime is then converted to nitrite." [MetaCyc:PWY-2242]
subset: gosubset_prok
xref: MetaCyc:PWY-2242
is_a: GO:0019329 ! ammonia oxidation

[Term]
id: GO:0070276
name: halogen metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any halogen, elements of Group VII; includes metabolism of halogen-containing compounds." [CHEBI:22473, GOC:mah]
synonym: "halogen metabolism" EXACT []
is_a: GO:0044281 ! small molecule metabolic process

[Term]
id: GO:0070277
name: iodide oxidation
namespace: biological_process
def: "The chemical reactions and pathways by which iodide is converted to diiodine, with the concomitant loss of electrons." [GOC:mah, MetaCyc:IODIDE-PEROXIDASE-RXN]
is_a: GO:0055114 ! oxidation-reduction process
is_a: GO:0070276 ! halogen metabolic process

[Term]
id: GO:0070278
name: extracellular matrix constituent secretion
namespace: biological_process
def: "The controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell." [GOC:mah]
synonym: "ECM constituent secretion" EXACT [GOC:mah]
synonym: "ECM secretion" EXACT [GOC:mah]
is_a: GO:0032940 ! secretion by cell
relationship: part_of GO:0030198 ! extracellular matrix organization

[Term]
id: GO:0070279
name: vitamin B6 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any of the vitamin B6 compounds: pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate." [GOC:mah]
is_a: GO:0019842 ! vitamin binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding

[Term]
id: GO:0070280
name: pyridoxal binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-carbaldehyde, a form of vitamin B6." [CHEBI:17310, GOC:mah]
is_a: GO:0070279 ! vitamin B6 binding

[Term]
id: GO:0070281
name: pyridoxamine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with pyridoxamine, 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, a form of vitamin B6." [CHEBI:16410, GOC:mah]
is_a: GO:0070279 ! vitamin B6 binding
is_a: GO:0070405 ! ammonium ion binding

[Term]
id: GO:0070282
name: pyridoxine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with pyridoxine, 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol, a form of vitamin B6." [CHEBI:16709, GOC:mah]
is_a: GO:0070279 ! vitamin B6 binding

[Term]
id: GO:0070283
name: radical SAM enzyme activity
namespace: molecular_function
def: "Catalysis of a reaction in which S-adenosyl-L-methionine (SAM) undergoes reductive cleavage to serve as a source of the 5'-deoxyadenosyl radical." [PMID:17291766, PMID:18307109]
xref: Reactome:REACT_25068 "Cyclisation of GTP to precursor Z, Homo sapiens"
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0070284
name: 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-aminoimidazole ribonucleotide + S-adenosylmethionine = 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate + 5'deoxyadenosine." [PMID:18953358]
synonym: "HMP-P synthase activity" EXACT [PMID:18953358]
synonym: "ThiC" RELATED [PMID:18953358]
is_a: GO:0016853 ! isomerase activity
is_a: GO:0070283 ! radical SAM enzyme activity

[Term]
id: GO:0070285
name: pigment cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a pigment cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a pigment cell fate." [GOC:cvs]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0050931 ! pigment cell differentiation

[Term]
id: GO:0070286
name: axonemal dynein complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:mah, PMID:19052621]
synonym: "dynein arm assembly" EXACT [GOC:vk, PMID:19944405]
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
is_a: GO:0043623 ! cellular protein complex assembly
relationship: part_of GO:0035082 ! axoneme assembly

[Term]
id: GO:0070287
name: ferritin receptor activity
namespace: molecular_function
def: "Combining with ferritin, and delivering ferritin into the cell via endocytosis." [GOC:bf, PMID:17459943, PMID:19154717]
synonym: "ferritin complex receptor activity" EXACT [GOC:mah]
is_a: GO:0038024 ! cargo receptor activity

[Term]
id: GO:0070288
name: ferritin complex
namespace: cellular_component
def: "A protein complex that binds iron and acts as a major iron storage system. Intracellular and extracellular ferritin complexes have different ratios of two types of ferritin monomer, the L (light) chain and H (heavy) chain." [GOC:mah, PMID:19154717]
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0070289
name: extracellular ferritin complex
namespace: cellular_component
def: "A ferritin complex located in the extracellular region. Extracellular ferritin complexes contain L (light) chains but few or no H (heavy) chains." [GOC:mah, PMID:19154717]
synonym: "serum ferritin complex" RELATED [PMID:19154717]
is_a: GO:0044421 ! extracellular region part
is_a: GO:0070288 ! ferritin complex

[Term]
id: GO:0070290
name: N-acylphosphatidylethanolamine-specific phospholipase D activity
namespace: molecular_function
def: "Catalysis of the release of N-acylethanolamine from N-acyl-phosphatidylethanolamine (NAPE) to generate N-acylethanolamine (NAE)." [GOC:elh, PMID:14634025, PMID:15878693]
subset: goslim_chembl
synonym: "N-acyl-phosphatidylethanolamine-specific phospholipase D activity" EXACT []
synonym: "NAPE-specific phospholipase D activity" EXACT []
xref: EC:3.1.4.4
is_a: GO:0004620 ! phospholipase activity
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0070291
name: N-acylethanolamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving N-acylethanolamines. An N-acylethanolamine is an ethanolamine substituted at nitrogen by an acyl group." [CHEBI:52640, GOC:elh, PMID:14634025, PMID:15878693]
synonym: "N-acylethanolamine metabolism" EXACT [GOC:elh, PMID:14634025, PMID:15877693]
synonym: "NAE metabolic process" EXACT [GOC:elh, PMID:14634025, PMID:15877693]
synonym: "NAE metabolism" EXACT [GOC:elh, PMID:14634025, PMID:15877693]
is_a: GO:0034308 ! primary alcohol metabolic process
is_a: GO:0042439 ! ethanolamine-containing compound metabolic process

[Term]
id: GO:0070292
name: N-acylphosphatidylethanolamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving N-acylphosphatidylethanolamines. An N-acylphosphatidylethanolamine is a phosphatidylethanolamine substituted at nitrogen by an acyl group." [GOC:elh, GOC:mah, PMID:14634025, PMID:15878693]
synonym: "N-acylphosphatidylethanolamine metabolism" EXACT [GOC:elh, PMID:14634025, PMID:15877693]
synonym: "NAPE metabolic process" EXACT [GOC:elh, PMID:14634025, PMID:15877693]
synonym: "NAPE metabolism" EXACT [GOC:elh, PMID:14634025, PMID:15877693]
is_a: GO:0043603 ! cellular amide metabolic process
is_a: GO:0046337 ! phosphatidylethanolamine metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process

[Term]
id: GO:0070293
name: renal absorption
namespace: biological_process
def: "A renal system process in which water, ions, glucose and proteins are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures (e.g. protein absorption is observed in nephrocytes in Drosophila, see PMID:23264686)." [GOC:dph, GOC:mah, GOC:yaf]
synonym: "nephron absorption" EXACT [GOC:mah]
synonym: "renal reabsorption" EXACT [GOC:dph]
is_a: GO:0003014 ! renal system process

[Term]
id: GO:0070294
name: renal sodium ion absorption
namespace: biological_process
def: "A renal system process in which sodium ions are taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures." [GOC:dph, GOC:mah]
synonym: "nephron sodium ion absorption" EXACT [GOC:mah]
synonym: "renal sodium ion reabsorption" EXACT [GOC:dph]
is_a: GO:0003096 ! renal sodium ion transport
is_a: GO:0070293 ! renal absorption

[Term]
id: GO:0070295
name: renal water absorption
namespace: biological_process
def: "A renal system process in which water is taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures." [GOC:dph, GOC:mah]
synonym: "nephron water absorption" EXACT [GOC:mah]
synonym: "renal water reabsorption" EXACT [GOC:dph]
is_a: GO:0003097 ! renal water transport
is_a: GO:0070293 ! renal absorption

[Term]
id: GO:0070296
name: sarcoplasmic reticulum calcium ion transport
namespace: biological_process
def: "The directed movement of calcium ions (Ca2+) into, out of or within the sarcoplasmic reticulum." [GOC:BHF, GOC:vk]
is_a: GO:0006816 ! calcium ion transport
is_a: GO:1902582 ! single-organism intracellular transport

[Term]
id: GO:0070297
name: regulation of phosphorelay signal transduction system
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of signal transduction via a phosphorelay signal transduction system." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of histidyl-aspartyl phosphorelay" EXACT [GOC:mah]
synonym: "regulation of two-component signal transduction system" EXACT [GOC:bf, GOC:mah]
synonym: "regulation of two-component signal transduction system (phosphorelay)" NARROW []
is_a: GO:1902531 ! regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000160 ! phosphorelay signal transduction system
relationship: regulates GO:0000160 ! phosphorelay signal transduction system

[Term]
id: GO:0070298
name: negative regulation of phosphorelay signal transduction system
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction via a phosphorelay signal transduction system." [GOC:mah]
synonym: "down regulation of two-component signal transduction" EXACT [GOC:mah]
synonym: "down-regulation of two-component signal transduction" EXACT [GOC:mah]
synonym: "downregulation of two-component signal transduction" EXACT [GOC:mah]
synonym: "inhibition of two-component signal transduction" NARROW [GOC:mah]
synonym: "negative regulation of histidyl-aspartyl phosphorelay" EXACT [GOC:mah]
synonym: "negative regulation of two-component signal transduction system (phosphorelay)" NARROW []
is_a: GO:0070297 ! regulation of phosphorelay signal transduction system
is_a: GO:1902532 ! negative regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000160 ! phosphorelay signal transduction system
relationship: negatively_regulates GO:0000160 ! phosphorelay signal transduction system

[Term]
id: GO:0070299
name: positive regulation of phosphorelay signal transduction system
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of signal transduction via a phosphorelay signal transduction system." [GOC:mah]
synonym: "activation of two-component signal transduction" NARROW [GOC:mah]
synonym: "positive regulation of histidyl-aspartyl phosphorelay" EXACT [GOC:mah]
synonym: "positive regulation of two-component signal transduction system (phosphorelay)" NARROW []
synonym: "stimulation of two-component signal transduction" NARROW [GOC:mah]
synonym: "up regulation of two-component signal transduction" EXACT [GOC:mah]
synonym: "up-regulation of two-component signal transduction" EXACT [GOC:mah]
synonym: "upregulation of two-component signal transduction" EXACT [GOC:mah]
is_a: GO:0070297 ! regulation of phosphorelay signal transduction system
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000160 ! phosphorelay signal transduction system
relationship: positively_regulates GO:0000160 ! phosphorelay signal transduction system

[Term]
id: GO:0070300
name: phosphatidic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids." [CHEBI:16337, GOC:jp, ISBN:0198506732]
synonym: "phosphatidate binding" EXACT [GOC:jp]
is_a: GO:0005543 ! phospholipid binding

[Term]
id: GO:0070301
name: cellular response to hydrogen peroxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus." [CHEBI:16240, GOC:mah]
is_a: GO:0034614 ! cellular response to reactive oxygen species
is_a: GO:0042542 ! response to hydrogen peroxide

[Term]
id: GO:0070302
name: regulation of stress-activated protein kinase signaling cascade
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of signaling via a stress-activated protein kinase signaling cascade." [GOC:mah]
synonym: "regulation of SAPK signaling pathway" EXACT [GOC:mah]
synonym: "regulation of stress-activated protein kinase signaling pathway" EXACT []
synonym: "regulation of stress-activated protein kinase signalling pathway" EXACT [GOC:mah]
is_a: GO:0080135 ! regulation of cellular response to stress
is_a: GO:1902531 ! regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031098 ! stress-activated protein kinase signaling cascade
relationship: regulates GO:0031098 ! stress-activated protein kinase signaling cascade

[Term]
id: GO:0070303
name: negative regulation of stress-activated protein kinase signaling cascade
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade." [GOC:mah]
synonym: "down regulation of stress-activated protein kinase signaling pathway" EXACT [GOC:mah]
synonym: "down-regulation of stress-activated protein kinase signaling pathway" EXACT [GOC:mah]
synonym: "downregulation of stress-activated protein kinase signaling pathway" EXACT [GOC:mah]
synonym: "inhibition of stress-activated protein kinase signaling pathway" NARROW [GOC:mah]
synonym: "negative regulation of SAPK signaling pathway" EXACT [GOC:mah]
synonym: "negative regulation of stress-activated protein kinase signaling pathway" EXACT []
synonym: "negative regulation of stress-activated protein kinase signalling pathway" EXACT [GOC:mah]
is_a: GO:0070302 ! regulation of stress-activated protein kinase signaling cascade
is_a: GO:1902532 ! negative regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0031098 ! stress-activated protein kinase signaling cascade
relationship: negatively_regulates GO:0031098 ! stress-activated protein kinase signaling cascade

[Term]
id: GO:0070304
name: positive regulation of stress-activated protein kinase signaling cascade
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade." [GOC:mah]
synonym: "activation of stress-activated protein kinase signaling pathway" NARROW [GOC:mah]
synonym: "positive regulation of SAPK signaling pathway" EXACT [GOC:mah]
synonym: "positive regulation of stress-activated protein kinase signaling pathway" EXACT []
synonym: "positive regulation of stress-activated protein kinase signalling pathway" EXACT [GOC:mah]
synonym: "stimulation of stress-activated protein kinase signaling pathway" NARROW [GOC:mah]
synonym: "up regulation of stress-activated protein kinase signaling pathway" EXACT [GOC:mah]
synonym: "up-regulation of stress-activated protein kinase signaling pathway" EXACT [GOC:mah]
synonym: "upregulation of stress-activated protein kinase signaling pathway" EXACT [GOC:mah]
is_a: GO:0070302 ! regulation of stress-activated protein kinase signaling cascade
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0031098 ! stress-activated protein kinase signaling cascade
relationship: positively_regulates GO:0031098 ! stress-activated protein kinase signaling cascade

[Term]
id: GO:0070305
name: response to cGMP
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cGMP (cyclic GMP, guanosine 3',5'-cyclophosphate) stimulus." [GOC:sl]
synonym: "response to 3',5' cGMP" EXACT [GOC:mah]
synonym: "response to 3',5'-cGMP" EXACT [GOC:mah]
synonym: "response to cyclic GMP" EXACT [GOC:mah]
synonym: "response to guanosine 3',5'-cyclophosphate" EXACT [GOC:mah]
is_a: GO:0014074 ! response to purine-containing compound
is_a: GO:0046683 ! response to organophosphorus
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0070306
name: lens fiber cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a lens fiber cell, any of the elongated, tightly packed cells that make up the bulk of the mature lens in the camera-type eye. The cytoplasm of a lens fiber cell is devoid of most intracellular organelles including the cell nucleus, and contains primarily crystallins, a group of water-soluble proteins expressed in vary large quantities." [GOC:mah, PMID:7693735]
synonym: "lens fibre cell differentiation" EXACT [GOC:mah]
is_a: GO:0030855 ! epithelial cell differentiation
relationship: part_of GO:0002088 ! lens development in camera-type eye

[Term]
id: GO:0070307
name: lens fiber cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a lens fiber cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a lens fiber cell fate. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye." [GOC:mah, PMID:7693735]
synonym: "lens fibre cell development" EXACT [GOC:mah]
is_a: GO:0002064 ! epithelial cell development
relationship: part_of GO:0070306 ! lens fiber cell differentiation

[Term]
id: GO:0070308
name: lens fiber cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a lens fiber cell. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye." [GOC:mah, PMID:7693735]
synonym: "lens fibre cell fate commitment" EXACT [GOC:mah]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0070306 ! lens fiber cell differentiation

[Term]
id: GO:0070309
name: lens fiber cell morphogenesis
namespace: biological_process
def: "The process in which the structures of a lens fiber cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a lens fiber cell. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye." [GOC:mah, PMID:7693735]
synonym: "elongation of lens fiber cell" NARROW [GOC:mah, GOC:vk]
synonym: "lens fiber cell morphogenesis during differentiation" EXACT systematic_synonym [GOC:mah]
synonym: "lens fibre cell morphogenesis" EXACT [GOC:mah]
is_a: GO:0000904 ! cell morphogenesis involved in differentiation
relationship: part_of GO:0002089 ! lens morphogenesis in camera-type eye
relationship: part_of GO:0070307 ! lens fiber cell development

[Term]
id: GO:0070310
name: ATR-ATRIP complex
namespace: cellular_component
def: "A protein complex that contains the protein kinase ATR and ATR-interacting protein (ATRIP) and binds single-stranded DNA; ssDNA binding affinity is increased in the presence of replication protein A." [GOC:mah, PMID:14724280]
synonym: "Mec1-Lcd1 complex" NARROW [PMID:17339343]
synonym: "Rad3-Rad26 complex" NARROW [PMID:17339343]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0070311
name: nucleosomal methylation activator complex
namespace: cellular_component
def: "A protein complex that contains eight subunits in common with the SWI/SNF complex, plus the ATPase BRG1 (SMARCA4) and the histone methyltransferase CARM1; the complex is involved in regulating nuclear receptor-dependent transcription." [GOC:mah, PMID:14729568]
synonym: "NUMAC" EXACT [PMID:14729568]
is_a: GO:0035097 ! histone methyltransferase complex

[Term]
id: GO:0070312
name: RAD52-ERCC4-ERCC1 complex
namespace: cellular_component
def: "A nucleotide-excision repair complex formed by the association of the heterodimeric endonuclease XPF/ERCC4-ERCC1 (Rad1p and Rad10p in S. cerevisiae) with the RAD52 protein." [PMID:14734547]
comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex.
is_a: GO:0000109 ! nucleotide-excision repair complex

[Term]
id: GO:0070313
name: RGS6-DNMT1-DMAP1 complex
namespace: cellular_component
def: "A protein complex formed by the association of RGS6, a negative regulator of heterotrimeric G protein signaling, with the DMAP1-Dnmt1 transcriptional repressor complex; in the complex, RGS6 inhibits the transcriptional repressor activity of DMAP1." [GOC:mah, PMID:14734556]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0070314
name: G1 to G0 transition
namespace: biological_process
def: "A cell cycle arrest process that results in arrest during G1 phase, whereupon the cell enters a specialized resting state known as G0 or quiescence." [GOC:mah, GOC:mtg_cell_cycle, ISBN:0815316194]
synonym: "cell cycle quiescence" RELATED [GOC:mah]
synonym: "establishment of cell quiescence" EXACT [GOC:mah]
synonym: "G1/G0 transition" EXACT [GOC:mah]
synonym: "stationary phase" RELATED [GOC:mah]
is_a: GO:0022402 ! cell cycle process

[Term]
id: GO:0070315
name: G1 to G0 transition involved in cell differentiation
namespace: biological_process
def: "A cell cycle arrest process that results in arrest during G1 phase, whereupon the cell enters G0 phase, in the context of cell differentiation." [GOC:mah, ISBN:0815316194]
synonym: "G1/G0 transition involved in cell differentiation" EXACT [GOC:mah]
is_a: GO:0070314 ! G1 to G0 transition
intersection_of: GO:0070314 ! G1 to G0 transition
intersection_of: part_of GO:0030154 ! cell differentiation
relationship: part_of GO:0030154 ! cell differentiation

[Term]
id: GO:0070316
name: regulation of G0 to G1 transition
namespace: biological_process
def: "A cell cycle process that modulates the rate or extent of the transition from the G0 quiescent state to the G1 phase." [GOC:mah]
is_a: GO:0010564 ! regulation of cell cycle process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045023 ! G0 to G1 transition
relationship: regulates GO:0045023 ! G0 to G1 transition

[Term]
id: GO:0070317
name: negative regulation of G0 to G1 transition
namespace: biological_process
def: "A cell cycle process that stops, prevents, or reduces the rate or extent of the transition from the G0 quiescent state to the G1 phase." [GOC:mah]
synonym: "maintenance of cell cycle quiescence" EXACT [GOC:mah]
synonym: "maintenance of cell quiescence" EXACT [GOC:mah]
synonym: "maintenance of G0 arrest" EXACT [GOC:mah]
synonym: "maintenance of G0 phase" EXACT [GOC:mah]
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0070316 ! regulation of G0 to G1 transition
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045023 ! G0 to G1 transition
relationship: negatively_regulates GO:0045023 ! G0 to G1 transition

[Term]
id: GO:0070318
name: positive regulation of G0 to G1 transition
namespace: biological_process
def: "A cell cycle process that activates or increases the rate or extent of the transition from the G0 quiescent state to the G1 phase." [GOC:mah]
is_a: GO:0070316 ! regulation of G0 to G1 transition
is_a: GO:0090068 ! positive regulation of cell cycle process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045023 ! G0 to G1 transition
relationship: positively_regulates GO:0045023 ! G0 to G1 transition

[Term]
id: GO:0070319
name: Golgi to plasma membrane transport vesicle
namespace: cellular_component
def: "A transport vesicle that mediates transport from the Golgi to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis." [GOC:kad, GOC:mah]
synonym: "Golgi to plasma membrane constitutive secretory pathway transport vesicle" EXACT []
synonym: "Golgi-plasma membrane transport vesicle" EXACT [GOC:mah]
is_a: GO:0070382 ! exocytic vesicle

[Term]
id: GO:0070320
name: inward rectifier potassium channel inhibitor activity
namespace: molecular_function
def: "Stops, prevents, or reduces the activity of an inwardly rectifying potassium channel." [GOC:mah]
is_a: GO:0019870 ! potassium channel inhibitor activity

[Term]
id: GO:0070321
name: regulation of translation in response to nitrogen starvation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the frequency, rate or extent of translation as a result of a stimulus indicating deprivation of nitrogen." [GOC:mah]
is_a: GO:0006995 ! cellular response to nitrogen starvation
is_a: GO:0043555 ! regulation of translation in response to stress

[Term]
id: GO:0070322
name: negative regulation of translation in response to nitrogen starvation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate of translation as a result of a stimulus indicating deprivation of nitrogen." [GOC:mah]
synonym: "down regulation of translation in response to nitrogen starvation" EXACT [GOC:mah]
synonym: "down-regulation of translation in response to nitrogen starvation" EXACT [GOC:mah]
synonym: "downregulation of translation in response to nitrogen starvation" EXACT [GOC:mah]
synonym: "inhibition of translation in response to nitrogen starvation" NARROW [GOC:mah]
is_a: GO:0032055 ! negative regulation of translation in response to stress
is_a: GO:0070321 ! regulation of translation in response to nitrogen starvation

[Term]
id: GO:0070323
name: positive regulation of translation in response to nitrogen starvation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating deprivation of nitrogen." [GOC:mah]
synonym: "activation of translation in response to nitrogen starvation" NARROW [GOC:mah]
synonym: "stimulation of translation in response to nitrogen starvation" NARROW [GOC:mah]
synonym: "up regulation of translation in response to nitrogen starvation" EXACT [GOC:mah]
synonym: "up-regulation of translation in response to nitrogen starvation" EXACT [GOC:mah]
synonym: "upregulation of translation in response to nitrogen starvation" EXACT [GOC:mah]
is_a: GO:0032056 ! positive regulation of translation in response to stress
is_a: GO:0070321 ! regulation of translation in response to nitrogen starvation

[Term]
id: GO:0070324
name: thyroid hormone binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with thyroxine (T4) or triiodothyronine (T3), tyrosine-based hormones produced by the thyroid gland." [GOC:rph]
subset: goslim_chembl
synonym: "thyroxine binding" NARROW [GOC:mah]
synonym: "triiodothyronine binding" NARROW [GOC:mah]
is_a: GO:0042562 ! hormone binding

[Term]
id: GO:0070325
name: lipoprotein particle receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a lipoprotein particle receptor." [GOC:BHF, GOC:rl]
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0070326
name: very-low-density lipoprotein particle receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a very-low-density lipoprotein receptor." [GOC:BHF, GOC:mah]
synonym: "apolipoprotein E receptor binding" RELATED [GOC:rl]
synonym: "very-low-density lipoprotein receptor binding" EXACT [GOC:bf, GOC:dph]
synonym: "VLDL receptor binding" EXACT [GOC:mah]
synonym: "VLDLR binding" EXACT [GOC:mah]
is_a: GO:0070325 ! lipoprotein particle receptor binding

[Term]
id: GO:0070327
name: thyroid hormone transport
namespace: biological_process
def: "The directed movement of thyroid hormone into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:rph]
synonym: "thyroxine transport" NARROW [GOC:mah]
synonym: "triiodothyronine transport" NARROW [GOC:mah]
is_a: GO:0009914 ! hormone transport
is_a: GO:0072337 ! modified amino acid transport

[Term]
id: GO:0070328
name: triglyceride homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell." [GOC:BHF, GOC:mah]
synonym: "triacylglycerol homeostasis" EXACT [GOC:rl]
is_a: GO:0055090 ! acylglycerol homeostasis

[Term]
id: GO:0070329
name: tRNA seleno-modification
namespace: biological_process
def: "The substitution of a selenium atom for a sulfur atom in a ribonucleotide in a tRNA molecule." [GOC:jsg, PMID:14594807]
subset: gosubset_prok
synonym: "tRNA base modification to selenouridine" EXACT [GOC:mah]
is_a: GO:0001887 ! selenium compound metabolic process
is_a: GO:0006400 ! tRNA modification

[Term]
id: GO:0070330
name: aromatase activity
namespace: molecular_function
def: "Catalysis of the reduction of an aliphatic ring to yield an aromatic ring." [GOC:cb]
subset: gosubset_prok
synonym: "estrogen synthetase activity" NARROW []
xref: EC:1.14.14.1
xref: MetaCyc:UNSPECIFIC-MONOOXYGENASE-RXN
xref: UM-BBD_enzymeID:e0551
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0070331
name: CD20-Lck-Fyn complex
namespace: cellular_component
def: "A protein complex that contains the cell-surface protein CD20 and the Src family tyrosine kinases Lck and Fyn." [GOC:mah, PMID:7545683]
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0070332
name: CD20-Lck-Lyn-Fyn complex
namespace: cellular_component
def: "A protein complex that contains the cell-surface protein CD20 and the Src family tyrosine kinases Lck, Lyn and Fyn." [GOC:mah, PMID:7545683]
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0070333
name: alpha6-beta4 integrin-Shc-Grb2 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha6-beta4 integrin complex bound to the adaptor proteins Shc and Grb2." [PMID:7556090]
synonym: "ITGA6-ITGB4-SHC-GRB2 complex" NARROW [CORUM:3096]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070334
name: alpha6-beta4 integrin-laminin 5 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha6-beta4 integrin complex bound to laminin 5." [GOC:mah, PMID:7556090]
synonym: "ITGA6-ITGB4-LAMA5 complex" NARROW [CORUM:2322]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070335
name: aspartate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with aspartate, the alpha-amino-acid anion of 2-aminobutanedioic acid that has formula C4H5NO4." [CHEBI:29995, GOC:mah]
synonym: "aspartic acid binding" EXACT [GOC:mah]
is_a: GO:0016597 ! amino acid binding

[Term]
id: GO:0070336
name: flap-structured DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a flap structure in DNA. A DNA flap structure is one in which a single-stranded length of DNA or RNA protrudes from a double-stranded DNA molecule." [GOC:mah, PMID:15189154]
subset: gosubset_prok
is_a: GO:0043566 ! structure-specific DNA binding

[Term]
id: GO:0070337
name: 3'-flap-structured DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a 3'-flap structure in DNA. A DNA flap structure is one in which a single-stranded 3'-end of DNA or RNA protrudes from a double-stranded DNA molecule." [GOC:mah, PMID:15189154]
subset: gosubset_prok
is_a: GO:0070336 ! flap-structured DNA binding

[Term]
id: GO:0070338
name: 5'-flap-structured DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a 5'-flap structure in DNA. A DNA flap structure is one in which a single-stranded 5'-end of DNA or RNA protrudes from a double-stranded DNA molecule. 5'-flap structures can be formed during DNA repair or lagging strand synthesis; in the latter case RNA flaps form from lagging strand RNA primers." [GOC:mah, PMID:15189154]
subset: gosubset_prok
is_a: GO:0070336 ! flap-structured DNA binding

[Term]
id: GO:0070339
name: response to bacterial lipopeptide
namespace: biological_process
def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacterial lipopeptide stimulus." [GOC:add, PMID:12077222]
is_a: GO:0032493 ! response to bacterial lipoprotein

[Term]
id: GO:0070340
name: detection of bacterial lipopeptide
namespace: biological_process
def: "The series of events in which a bacterial lipopeptide stimulus is received by a cell and converted into a molecular signal." [GOC:add, PMID:12077222]
is_a: GO:0042494 ! detection of bacterial lipoprotein
is_a: GO:0070339 ! response to bacterial lipopeptide

[Term]
id: GO:0070341
name: fat cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of fat cells by cell division, resulting in the expansion of their population. A fat cell is an animal connective tissue cell specialized for the synthesis and storage of fat." [GOC:mah, GOC:sl]
synonym: "adipocyte proliferation" EXACT [GOC:sl]
synonym: "adipose cell proliferation" EXACT [GOC:sl]
is_a: GO:0008283 ! cell proliferation

[Term]
id: GO:0070342
name: brown fat cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of brown fat cells by cell division, resulting in the expansion of their population. A brown fat cell is a fat cell found the thermogenic form of adipose tissue found in newborns of many species." [CL:0000449, GOC:mah, GOC:sl]
synonym: "brown adipocyte proliferation" EXACT [GOC:sl]
synonym: "brown adipose cell proliferation" EXACT [GOC:sl]
is_a: GO:0070341 ! fat cell proliferation

[Term]
id: GO:0070343
name: white fat cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of white fat cells by cell division, resulting in the expansion of their population." [CL:0000448, GOC:mah, GOC:sl]
synonym: "white adipocyte proliferation" EXACT [GOC:sl]
synonym: "white adipose cell proliferation" EXACT [GOC:sl]
is_a: GO:0070341 ! fat cell proliferation

[Term]
id: GO:0070344
name: regulation of fat cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fat cell proliferation." [GOC:mah, GOC:sl]
synonym: "regulation of adipocyte proliferation" EXACT [GOC:sl]
synonym: "regulation of adipose cell proliferation" EXACT [GOC:sl]
is_a: GO:0042127 ! regulation of cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070341 ! fat cell proliferation
relationship: regulates GO:0070341 ! fat cell proliferation

[Term]
id: GO:0070345
name: negative regulation of fat cell proliferation
namespace: biological_process
def: "Any process that stops or decreases the rate or extent of fat cell proliferation." [GOC:mah, GOC:sl]
synonym: "down regulation of fat cell proliferation" EXACT [GOC:mah]
synonym: "down-regulation of fat cell proliferation" EXACT [GOC:mah]
synonym: "downregulation of fat cell proliferation" EXACT [GOC:mah]
synonym: "inhibition of fat cell proliferation" NARROW [GOC:mah]
synonym: "negative regulation of adipocyte proliferation" EXACT [GOC:sl]
synonym: "negative regulation of adipose cell proliferation" EXACT [GOC:sl]
is_a: GO:0008285 ! negative regulation of cell proliferation
is_a: GO:0070344 ! regulation of fat cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070341 ! fat cell proliferation
relationship: negatively_regulates GO:0070341 ! fat cell proliferation

[Term]
id: GO:0070346
name: positive regulation of fat cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of fat cell proliferation." [GOC:mah, GOC:sl]
synonym: "activation of fat cell proliferation" NARROW [GOC:mah]
synonym: "positive regulation of adipocyte proliferation" EXACT [GOC:sl]
synonym: "positive regulation of adipose cell proliferation" EXACT [GOC:sl]
synonym: "stimulation of fat cell proliferation" NARROW [GOC:mah]
synonym: "up regulation of fat cell proliferation" EXACT [GOC:mah]
synonym: "up-regulation of fat cell proliferation" EXACT [GOC:mah]
synonym: "upregulation of fat cell proliferation" EXACT [GOC:mah]
is_a: GO:0008284 ! positive regulation of cell proliferation
is_a: GO:0070344 ! regulation of fat cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070341 ! fat cell proliferation
relationship: positively_regulates GO:0070341 ! fat cell proliferation

[Term]
id: GO:0070347
name: regulation of brown fat cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of brown fat cell proliferation." [GOC:mah, GOC:sl]
synonym: "regulation of brown adipocyte proliferation" EXACT [GOC:sl]
synonym: "regulation of brown adipose cell proliferation" EXACT [GOC:sl]
is_a: GO:0070344 ! regulation of fat cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070342 ! brown fat cell proliferation
relationship: regulates GO:0070342 ! brown fat cell proliferation

[Term]
id: GO:0070348
name: negative regulation of brown fat cell proliferation
namespace: biological_process
def: "Any process that stops or decreases the rate or extent of brown fat cell proliferation." [GOC:mah, GOC:sl]
synonym: "down regulation of brown fat cell proliferation" EXACT [GOC:mah]
synonym: "down-regulation of brown fat cell proliferation" EXACT [GOC:mah]
synonym: "downregulation of brown fat cell proliferation" EXACT [GOC:mah]
synonym: "inhibition of brown fat cell proliferation" NARROW [GOC:mah]
synonym: "negative regulation of brown adipocyte proliferation" EXACT [GOC:sl]
synonym: "negative regulation of brown adipose cell proliferation" EXACT [GOC:sl]
is_a: GO:0070345 ! negative regulation of fat cell proliferation
is_a: GO:0070347 ! regulation of brown fat cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070342 ! brown fat cell proliferation
relationship: negatively_regulates GO:0070342 ! brown fat cell proliferation

[Term]
id: GO:0070349
name: positive regulation of brown fat cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of brown fat cell proliferation." [GOC:mah, GOC:sl]
synonym: "activation of brown fat cell proliferation" NARROW [GOC:mah]
synonym: "positive regulation of brown adipocyte proliferation" EXACT [GOC:sl]
synonym: "positive regulation of brown adipose cell proliferation" EXACT [GOC:sl]
synonym: "stimulation of brown fat cell proliferation" NARROW [GOC:mah]
synonym: "up regulation of brown fat cell proliferation" EXACT [GOC:mah]
synonym: "up-regulation of brown fat cell proliferation" EXACT [GOC:mah]
synonym: "upregulation of brown fat cell proliferation" EXACT [GOC:mah]
is_a: GO:0070346 ! positive regulation of fat cell proliferation
is_a: GO:0070347 ! regulation of brown fat cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070342 ! brown fat cell proliferation
relationship: positively_regulates GO:0070342 ! brown fat cell proliferation

[Term]
id: GO:0070350
name: regulation of white fat cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of white fat cell proliferation." [GOC:mah, GOC:sl]
synonym: "regulation of white adipocyte proliferation" EXACT [GOC:sl]
synonym: "regulation of white adipose cell proliferation" EXACT [GOC:sl]
is_a: GO:0070344 ! regulation of fat cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070343 ! white fat cell proliferation
relationship: regulates GO:0070343 ! white fat cell proliferation

[Term]
id: GO:0070351
name: negative regulation of white fat cell proliferation
namespace: biological_process
def: "Any process that stops or decreases the rate or extent of white fat cell proliferation." [GOC:mah, GOC:sl]
synonym: "down regulation of white fat cell proliferation" EXACT [GOC:mah]
synonym: "down-regulation of white fat cell proliferation" EXACT [GOC:mah]
synonym: "downregulation of white fat cell proliferation" EXACT [GOC:mah]
synonym: "inhibition of white fat cell proliferation" NARROW [GOC:mah]
synonym: "negative regulation of white adipocyte proliferation" EXACT [GOC:sl]
synonym: "negative regulation of white adipose cell proliferation" EXACT [GOC:sl]
is_a: GO:0070345 ! negative regulation of fat cell proliferation
is_a: GO:0070350 ! regulation of white fat cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070343 ! white fat cell proliferation
relationship: negatively_regulates GO:0070343 ! white fat cell proliferation

[Term]
id: GO:0070352
name: positive regulation of white fat cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of white fat cell proliferation." [GOC:mah, GOC:sl]
synonym: "activation of white fat cell proliferation" NARROW [GOC:mah]
synonym: "positive regulation of white adipocyte proliferation" EXACT [GOC:sl]
synonym: "positive regulation of white adipose cell proliferation" EXACT [GOC:sl]
synonym: "stimulation of white fat cell proliferation" NARROW [GOC:mah]
synonym: "up regulation of white fat cell proliferation" EXACT [GOC:mah]
synonym: "up-regulation of white fat cell proliferation" EXACT [GOC:mah]
synonym: "upregulation of white fat cell proliferation" EXACT [GOC:mah]
is_a: GO:0070346 ! positive regulation of fat cell proliferation
is_a: GO:0070350 ! regulation of white fat cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070343 ! white fat cell proliferation
relationship: positively_regulates GO:0070343 ! white fat cell proliferation

[Term]
id: GO:0070353
name: GATA1-TAL1-TCF3-Lmo2 complex
namespace: cellular_component
def: "A protein complex that contains the zinc finger transcription factor GATA1, the LIM domain protein Lmo2 (RBTN2), the basic helix-loop-helix protein TAL1 and its binding partner TCF3. The complex is involved transcriptional regulation in hematopoiesis." [PMID:7568177]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0070354
name: GATA2-TAL1-TCF3-Lmo2 complex
namespace: cellular_component
def: "A protein complex that contains the zinc finger transcription factor GATA2, the LIM domain protein Lmo2 (RBTN2), the basic helix-loop-helix protein TAL1 and its binding partner TCF3. The complex is involved transcriptional regulation in hematopoiesis." [PMID:7568177]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0070355
name: synaptotagmin-synaptobrevin 2-SNAP-25-syntaxin-1a-syntaxin-1b-Rab3a-complexin II complex
namespace: cellular_component
def: "A SNARE complex that contains synaptotagmin, synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, syntaxin1b, Rab3a, and complexin II (or orthologs thereof)." [PMID:7654227]
synonym: "SNARE complex (STX1a, STX1b, SNAP25, RAB3a, SYT1, VAMP2, CPLX2)" NARROW [CORUM:1247]
synonym: "STX1a-STX1b-SNAP25-RAB3a-SYT1-VAMP2-CPLX2 complex" NARROW [CORUM:1247]
is_a: GO:0031201 ! SNARE complex

[Term]
id: GO:0070356
name: synaptotagmin-synaptobrevin 2-SNAP-25-syntaxin-1a-syntaxin-1b-Rab3a complex
namespace: cellular_component
def: "A SNARE complex that contains synaptotagmin, synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, syntaxin1b, and Rab3a (or orthologs thereof)." [PMID:7654227]
synonym: "SNARE complex (STX1a, STX1b, SNAP25, RAB3a, SYT1, VAMP2)" NARROW [CORUM:1244]
synonym: "STX1a-STX1b-SNAP25-RAB3a-SYT1-VAMP2 complex" NARROW [CORUM:1244]
is_a: GO:0031201 ! SNARE complex

[Term]
id: GO:0070357
name: alphav-beta3 integrin-CD47 complex
namespace: cellular_component
def: "A protein complex that consists of an alphav-beta3 integrin complex bound to CD47 (also known as IAP)." [PMID:2277087, PMID:7691831]
synonym: "ITGB3-ITGAV-CD47 complex" NARROW [CORUM:2356]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070358
name: actin polymerization-dependent cell motility
namespace: biological_process
def: "A process involved in the controlled movement of a bacterial cell powered by the continuous polymerization of actin at one pole of the cell." [GOC:mah, PMID:15773977]
subset: gosubset_prok
synonym: "cell motility by actin tail formation" EXACT [PMID:15773977]
is_a: GO:0048870 ! cell motility

[Term]
id: GO:0070359
name: actin polymerization-dependent cell motility involved in migration of symbiont in host
namespace: biological_process
def: "A process involved in the controlled movement of a bacterial cell within a host cell, powered by the continuous polymerization of host actin at one pole of the cell." [GOC:jl, GOC:mah, PMID:15773977]
subset: gosubset_prok
synonym: "actin polymerization-dependent cell motility involved in migration of symbiont within host" EXACT []
is_a: GO:0070358 ! actin polymerization-dependent cell motility
relationship: part_of GO:0070360 ! migration of symbiont within host by polymerization of host actin

[Term]
id: GO:0070360
name: migration of symbiont within host by polymerization of host actin
namespace: biological_process
def: "The directional movement of an organism, usually a bacterial cell, from one place to another within its host organism, by a process involving continuous polymerization of host actin at one pole of the symbiont cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:mah]
subset: gosubset_prok
is_a: GO:0044001 ! migration in host

[Term]
id: GO:0070361
name: mitochondrial light strand promoter anti-sense binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the anti-sense strand of the light strand promoter, a promoter located on the light, or cytosine-rich, strand of mitochondrial DNA." [GOC:mah, PMID:9485316]
comment: Note that as agreed during the transcription overhaul, terms specifying binding to specific transcription regulatory motifs are no longer being created. The level of specificity GO has decided to go to is the "core promoter", "core promoter proximal region" and "enhancer". To capture more detail, please consider using column 16.
synonym: "LSP non-coding strand binding" EXACT [PMID:9485316]
synonym: "LSPas binding" EXACT [PMID:9485316]
is_a: GO:0044212 ! transcription regulatory region DNA binding

[Term]
id: GO:0070362
name: mitochondrial heavy strand promoter anti-sense binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the anti-sense strand of the heavy strand promoter, a promoter located on the heavy, or guanine-rich, strand of mitochondrial DNA." [GOC:mah, PMID:9485316]
comment: Note that as agreed during the transcription overhaul, terms specifying binding to specific transcription regulatory motifs are no longer being created. The level of specificity GO has decided to go to is the "core promoter", "core promoter proximal region" and "enhancer". To capture more detail, please consider using column 16.
synonym: "HSP non-coding strand binding" EXACT [PMID:9485316]
synonym: "HSPas binding" EXACT [PMID:9485316]
is_a: GO:0044212 ! transcription regulatory region DNA binding

[Term]
id: GO:0070363
name: mitochondrial light strand promoter sense binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the sense strand of the light strand promoter, a promoter located on the light, or cytosine-rich, strand of mitochondrial DNA." [GOC:mah, PMID:9485316]
comment: Note that as agreed during the transcription overhaul, terms specifying binding to specific transcription regulatory motifs are no longer being created. The level of specificity GO has decided to go to is the "core promoter", "core promoter proximal region" and "enhancer". To capture more detail, please consider using column 16.
synonym: "LSP coding strand binding" EXACT [PMID:9485316]
synonym: "LSPs binding" EXACT [PMID:9485316]
is_a: GO:0044212 ! transcription regulatory region DNA binding

[Term]
id: GO:0070364
name: mitochondrial heavy strand promoter sense binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the sense strand of the heavy strand promoter, a promoter located on the heavy, or guanine-rich, strand of mitochondrial DNA." [GOC:mah, PMID:9485316]
comment: Note that as agreed during the transcription overhaul, terms specifying binding to specific transcription regulatory motifs are no longer being created. The level of specificity GO has decided to go to is the "core promoter", "core promoter proximal region" and "enhancer". To capture more detail, please consider using column 16.
synonym: "HSP coding strand binding" EXACT [PMID:9485316]
synonym: "HSPs binding" EXACT [PMID:9485316]
is_a: GO:0044212 ! transcription regulatory region DNA binding

[Term]
id: GO:0070365
name: hepatocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a hepatocyte. A hepatocyte is specialized epithelial cell that is organized into interconnected plates called lobules, and is the main structural component of the liver." [CL:0000182, PMID:7588884]
synonym: "liver cell differentiation" EXACT [GOC:mah]
is_a: GO:0030855 ! epithelial cell differentiation
relationship: part_of GO:0001889 ! liver development

[Term]
id: GO:0070366
name: regulation of hepatocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hepatocyte differentiation." [GOC:mah, GOC:sl]
synonym: "regulation of liver cell differentiation" EXACT [GOC:sl]
is_a: GO:0030856 ! regulation of epithelial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070365 ! hepatocyte differentiation
relationship: regulates GO:0070365 ! hepatocyte differentiation

[Term]
id: GO:0070367
name: negative regulation of hepatocyte differentiation
namespace: biological_process
def: "Any process that stops or decreases the rate or extent of hepatocyte differentiation." [GOC:mah, GOC:sl]
synonym: "down regulation of hepatocyte differentiation" EXACT [GOC:mah]
synonym: "down-regulation of hepatocyte differentiation" EXACT [GOC:mah]
synonym: "downregulation of hepatocyte differentiation" EXACT [GOC:mah]
synonym: "inhibition of hepatocyte differentiation" NARROW [GOC:mah]
synonym: "negative regulation of liver cell differentiation" EXACT [GOC:sl]
is_a: GO:0030857 ! negative regulation of epithelial cell differentiation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0070366 ! regulation of hepatocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070365 ! hepatocyte differentiation
relationship: negatively_regulates GO:0070365 ! hepatocyte differentiation

[Term]
id: GO:0070368
name: positive regulation of hepatocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of hepatocyte differentiation." [GOC:mah, GOC:sl]
synonym: "activation of hepatocyte differentiation" NARROW [GOC:mah]
synonym: "positive regulation of liver cell differentiation" EXACT [GOC:sl]
synonym: "stimulation of hepatocyte differentiation" NARROW [GOC:mah]
synonym: "up regulation of hepatocyte differentiation" EXACT [GOC:mah]
synonym: "up-regulation of hepatocyte differentiation" EXACT [GOC:mah]
synonym: "upregulation of hepatocyte differentiation" EXACT [GOC:mah]
is_a: GO:0030858 ! positive regulation of epithelial cell differentiation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0070366 ! regulation of hepatocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070365 ! hepatocyte differentiation
relationship: positively_regulates GO:0070365 ! hepatocyte differentiation

[Term]
id: GO:0070369
name: beta-catenin-TCF7L2 complex
namespace: cellular_component
def: "A protein complex that contains beta-catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription." [GOC:BHF, GOC:rl, PMID:9065401, PMID:9065402]
subset: gosubset_prok
synonym: "beta-catenin-TCF4 complex" EXACT [PMID:9065401, PMID:9065402]
is_a: GO:0071664 ! catenin-TCF7L2 complex
is_a: GO:1990907 ! beta-catenin-TCF complex

[Term]
id: GO:0070370
name: cellular heat acclimation
namespace: biological_process
def: "Any process that increases heat tolerance of a cell in response to high temperatures." [GOC:jp]
synonym: "cellular thermotolerance" EXACT [GOC:jp]
is_a: GO:0010286 ! heat acclimation
is_a: GO:0034605 ! cellular response to heat

[Term]
id: GO:0070371
name: ERK1 and ERK2 cascade
namespace: biological_process
def: "An intracellular protein kinase cascade containing at least ERK1 or ERK2 (MAPKs), a MEK (a MAPKK) and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell." [GOC:add, GOC:signaling, ISBN:0121245462, ISBN:0896039986, PMID:20811974]
comment: Note that this MAPKKK cascade is commonly referred to as the ERK pathway in the literature, but involves only ERK1 or ERK2, not other ERK kinases.
synonym: "ERK cascade" BROAD [GOC:add]
synonym: "ERK1 and ERK2 signaling pathway" EXACT [GOC:mah]
synonym: "ERK1 and ERK2 signalling pathway" EXACT [GOC:mah]
synonym: "ERK1 cascade" NARROW [GOC:add]
synonym: "ERK1/2 cascade" EXACT [GOC:add]
synonym: "ERK2 cascade" NARROW [GOC:add]
synonym: "extracellular signal-regulated kinase 1/2 (ERK1/2) cascade" EXACT [PMID:20811974]
synonym: "extracellular signal-regulated kinase 1/2 cascade" EXACT [PMID:20811974]
synonym: "MAPK1 cascade" NARROW [GOC:add]
synonym: "MAPK3 cascade" NARROW [GOC:add]
xref: Reactome:REACT_100214 "ERK2 activation, Rattus norvegicus"
xref: Reactome:REACT_102658 "ERK2 activation, Gallus gallus"
xref: Reactome:REACT_107705 "ERK2 activation, Mus musculus"
xref: Reactome:REACT_110773 "ERK2 activation, Danio rerio"
xref: Reactome:REACT_111031 "ERK2 activation, Taeniopygia guttata"
xref: Reactome:REACT_112775 "ERK2 activation, Arabidopsis thaliana"
xref: Reactome:REACT_112819 "ERK2 activation, Dictyostelium discoideum"
xref: Reactome:REACT_115367 "ERK2 activation, Oryza sativa"
xref: Reactome:REACT_1183 "ERK2 activation, Homo sapiens"
xref: Reactome:REACT_25141 "ERK2 activation, Gallus gallus"
xref: Reactome:REACT_25393 "ERK activation, Gallus gallus"
xref: Reactome:REACT_29696 "ERK2 activation, Saccharomyces cerevisiae"
xref: Reactome:REACT_77794 "ERK2 activation, Xenopus tropicalis"
xref: Reactome:REACT_77829 "ERK2 activation, Bos taurus"
xref: Reactome:REACT_81711 "ERK2 activation, Drosophila melanogaster"
xref: Reactome:REACT_90463 "ERK2 activation, Caenorhabditis elegans"
xref: Reactome:REACT_94688 "ERK2 activation, Sus scrofa"
xref: Reactome:REACT_97178 "ERK2 activation, Schizosaccharomyces pombe"
xref: Reactome:REACT_97662 "ERK2 activation, Canis familiaris"
is_a: GO:0000165 ! MAPK cascade

[Term]
id: GO:0070372
name: regulation of ERK1 and ERK2 cascade
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade." [GOC:add, ISBN:0121245462, ISBN:0896039986]
synonym: "regulation of ERK cascade" BROAD [GOC:add]
synonym: "regulation of ERK1 and ERK2 signaling pathway" EXACT [GOC:mah]
synonym: "regulation of ERK1 and ERK2 signalling pathway" EXACT [GOC:mah]
synonym: "regulation of ERK1 cascade" NARROW [GOC:add]
synonym: "regulation of ERK1/2 cascade" EXACT [GOC:add]
synonym: "regulation of ERK2 cascade" NARROW [GOC:add]
synonym: "regulation of MAPK1 cascade" NARROW [GOC:add]
synonym: "regulation of MAPK3 cascade" NARROW [GOC:add]
is_a: GO:0043408 ! regulation of MAPK cascade
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070371 ! ERK1 and ERK2 cascade
relationship: regulates GO:0070371 ! ERK1 and ERK2 cascade

[Term]
id: GO:0070373
name: negative regulation of ERK1 and ERK2 cascade
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade." [GOC:add, ISBN:0121245462, ISBN:0896039986]
synonym: "down regulation of ERK1 and ERK2 cascade" EXACT [GOC:mah]
synonym: "down-regulation of ERK1 and ERK2 cascade" EXACT [GOC:mah]
synonym: "downregulation of ERK1 and ERK2 cascade" EXACT [GOC:mah]
synonym: "inhibition of ERK1 and ERK2 cascade" NARROW [GOC:mah]
synonym: "negative regulation of ERK cascade" BROAD [GOC:add]
synonym: "negative regulation of ERK1 and ERK2 signaling pathway" EXACT [GOC:mah]
synonym: "negative regulation of ERK1 and ERK2 signalling pathway" EXACT [GOC:mah]
synonym: "negative regulation of ERK1 cascade" NARROW [GOC:add]
synonym: "negative regulation of ERK1/2 cascade" EXACT [GOC:add]
synonym: "negative regulation of ERK2 cascade" NARROW [GOC:add]
synonym: "negative regulation of MAPK1 cascade" NARROW [GOC:add]
synonym: "negative regulation of MAPK3 cascade" NARROW [GOC:add]
is_a: GO:0043409 ! negative regulation of MAPK cascade
is_a: GO:0070372 ! regulation of ERK1 and ERK2 cascade
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070371 ! ERK1 and ERK2 cascade
relationship: negatively_regulates GO:0070371 ! ERK1 and ERK2 cascade

[Term]
id: GO:0070374
name: positive regulation of ERK1 and ERK2 cascade
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade." [GOC:mah]
synonym: "activation of ERK1 and ERK2 cascade" NARROW [GOC:mah]
synonym: "positive regulation of ERK cascade" BROAD [GOC:add]
synonym: "positive regulation of ERK1 and ERK2 signaling pathway" EXACT [GOC:mah]
synonym: "positive regulation of ERK1 and ERK2 signalling pathway" EXACT [GOC:mah]
synonym: "positive regulation of ERK1 cascade" NARROW [GOC:add]
synonym: "positive regulation of ERK1/2 cascade" EXACT [GOC:add]
synonym: "positive regulation of ERK2 cascade" NARROW [GOC:add]
synonym: "positive regulation of MAPK1 cascade" NARROW [GOC:add]
synonym: "positive regulation of MAPK3 cascade" NARROW [GOC:add]
synonym: "stimulation of ERK1 and ERK2 cascade" NARROW [GOC:mah]
synonym: "up regulation of ERK1 and ERK2 cascade" EXACT [GOC:mah]
synonym: "up-regulation of ERK1 and ERK2 cascade" EXACT [GOC:mah]
synonym: "upregulation of ERK1 and ERK2 cascade" EXACT [GOC:mah]
is_a: GO:0043410 ! positive regulation of MAPK cascade
is_a: GO:0070372 ! regulation of ERK1 and ERK2 cascade
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070371 ! ERK1 and ERK2 cascade
relationship: positively_regulates GO:0070371 ! ERK1 and ERK2 cascade

[Term]
id: GO:0070375
name: ERK5 cascade
namespace: biological_process
def: "An intracellular protein kinase cascade containing at least ERK5 (also called BMK1; a MAPK), a MEK (a MAPKK) and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell." [GOC:add, GOC:signaling, ISBN:0896039986, PMID:16376520, PMID:16880823, PMID:20811974]
synonym: "big MAP kinase signaling cascade" EXACT [PMID:20811974]
synonym: "BMK cascade" EXACT [PMID:20811974]
synonym: "BMK signaling pathway" EXACT [GOC:mah]
synonym: "BMK signalling pathway" EXACT [GOC:mah]
synonym: "BMK1 cascade" EXACT [GOC:add]
synonym: "ERK5 signaling pathway" EXACT [PMID:16376520]
synonym: "extracellular signal-regulated kinase 5 cascade" EXACT [PMID:20811974]
synonym: "MAPK7 cascade" EXACT [GOC:add]
is_a: GO:0000165 ! MAPK cascade

[Term]
id: GO:0070376
name: regulation of ERK5 cascade
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK5 cascade." [GOC:add, ISBN:0121245462, ISBN:0896039986]
synonym: "regulation of BMK cascade" EXACT [GOC:signaling]
synonym: "regulation of BMK signaling pathway" EXACT [GOC:mah]
synonym: "regulation of BMK signalling pathway" EXACT [GOC:mah]
synonym: "regulation of BMK1 cascade" EXACT [GOC:add]
synonym: "regulation of ERK5 signaling pathway" EXACT [PMID:16376520]
synonym: "regulation of MAPK7 cascade" EXACT [GOC:add]
is_a: GO:0043408 ! regulation of MAPK cascade
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070375 ! ERK5 cascade
relationship: regulates GO:0070375 ! ERK5 cascade

[Term]
id: GO:0070377
name: negative regulation of ERK5 cascade
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK5 cascade." [GOC:add, ISBN:0121245462, ISBN:0896039986]
synonym: "down regulation of BMK cascade" EXACT [GOC:mah]
synonym: "down-regulation of BMK cascade" EXACT [GOC:mah]
synonym: "downregulation of BMK cascade" EXACT [GOC:mah]
synonym: "inhibition of BMK cascade" NARROW [GOC:mah]
synonym: "negative regulation of BMK cascade" EXACT [GOC:signaling]
synonym: "negative regulation of BMK signaling pathway" EXACT [GOC:mah]
synonym: "negative regulation of BMK signalling pathway" EXACT [GOC:mah]
synonym: "negative regulation of BMK1 cascade" EXACT [GOC:add]
synonym: "negative regulation of ERK5 signaling pathway" EXACT [PMID:16376520]
synonym: "negative regulation of MAPK7 cascade" EXACT [GOC:add]
is_a: GO:0043409 ! negative regulation of MAPK cascade
is_a: GO:0070376 ! regulation of ERK5 cascade
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070375 ! ERK5 cascade
relationship: negatively_regulates GO:0070375 ! ERK5 cascade

[Term]
id: GO:0070378
name: positive regulation of ERK5 cascade
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK5 cascade." [GOC:mah]
synonym: "activation of BMK cascade" NARROW [GOC:mah]
synonym: "positive regulation of BMK cascade" EXACT [GOC:signaling]
synonym: "positive regulation of BMK signaling pathway" EXACT [GOC:mah]
synonym: "positive regulation of BMK signalling pathway" EXACT [GOC:mah]
synonym: "positive regulation of BMK1 cascade" EXACT [GOC:add]
synonym: "positive regulation of ERK5 signaling pathway" EXACT [PMID:16376520]
synonym: "positive regulation of MAPK7 cascade" EXACT [GOC:add]
synonym: "stimulation of BMK cascade" NARROW [GOC:mah]
synonym: "up regulation of BMK cascade" EXACT [GOC:mah]
synonym: "up-regulation of BMK cascade" EXACT [GOC:mah]
synonym: "upregulation of BMK cascade" EXACT [GOC:mah]
is_a: GO:0043410 ! positive regulation of MAPK cascade
is_a: GO:0070376 ! regulation of ERK5 cascade
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070375 ! ERK5 cascade
relationship: positively_regulates GO:0070375 ! ERK5 cascade

[Term]
id: GO:0070379
name: high mobility group box 1 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with high mobility group box 1 (HMBGB1)." [GOC:add, PMID:18431461]
synonym: "HMGB1 binding" EXACT [GOC:add]
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0070380
name: high mobility group box 1 receptor activity
namespace: molecular_function
def: "Combining with high mobility group box 1 (HMBGB1) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, PMID:18431461]
synonym: "HMGB1 receptor activity" EXACT [GOC:add]
is_a: GO:0004896 ! cytokine receptor activity
relationship: has_part GO:0070379 ! high mobility group box 1 binding

[Term]
id: GO:0070381
name: endosome to plasma membrane transport vesicle
namespace: cellular_component
def: "A transport vesicle that mediates transport from the endosome to the plasma membrane, and fuses with the plasma membrane to deliver lipids and membrane proteins to the plasma membrane  and to release various cargo molecules, such as proteins or hormones, by exocytosis." [GOC:kad, GOC:mah, PMID:10679016, PMID:12110576]
synonym: "endosome to plasma membrane constitutive secretory pathway transport vesicle" EXACT []
synonym: "endosome-plasma membrane transport vesicle" EXACT [GOC:mah]
is_a: GO:0070382 ! exocytic vesicle

[Term]
id: GO:0070382
name: exocytic vesicle
namespace: cellular_component
def: "A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis." [GOC:kad, GOC:mah]
synonym: "exocytic constitutive secretory pathway transport vesicle" EXACT []
synonym: "exocytotic vesicle" EXACT [GOC:kad]
is_a: GO:0030133 ! transport vesicle
is_a: GO:0099503 ! secretory vesicle

[Term]
id: GO:0070383
name: DNA cytosine deamination
namespace: biological_process
def: "The removal of an amino group from a cytosine residue in DNA, forming a uracil residue." [GOC:mah]
is_a: GO:0045006 ! DNA deamination

[Term]
id: GO:0070384
name: Harderian gland development
namespace: biological_process
def: "The process whose specific outcome is the progression of the Harderian gland over time, from its formation to the mature structure. The Harderian gland is an anterior orbital structure usually associated with the nictitating membrane, and produces and secretes a variety of substances to the eye, depending upon the species." [GOC:hjd, PMID:16856596, PMID:7559104]
comment: Note that the Harderian gland is found in all terrestrial vertebrate groups, including amphibia, reptiles, birds, and mammals. However, it appears to be absent in certain mammals such as bats, cows, horses, and higher primates. Though largely absent in the adult human, it is present in the fetal and neonatal stages.
is_a: GO:0032808 ! lacrimal gland development

[Term]
id: GO:0070385
name: egasyn-beta-glucuronidase complex
namespace: cellular_component
def: "A protein complex that contains beta-glucuronidase and the carboxyl esterase egasyn; formation of the complex causes beta-glucuronidase to be retained in the endoplasmic reticulum." [PMID:7744842]
is_a: GO:0043234 ! protein complex
is_a: GO:0044432 ! endoplasmic reticulum part

[Term]
id: GO:0070386
name: procollagen-proline 4-dioxygenase complex, alpha(I) type
namespace: cellular_component
def: "A procollagen-proline 4-dioxygenase complex that contains alpha subunits of the type I isoform; its activity is readily inhibited by poly(L-proline)." [PMID:14500733, PMID:7753822]
synonym: "procollagen-proline, 2-oxoglutarate-4-dioxygenase complex, alpha(I) type" EXACT [PMID:7753822]
synonym: "prolyl 4-hydroxylase complex (alpha(I)-type)" BROAD [CORUM:472]
is_a: GO:0016222 ! procollagen-proline 4-dioxygenase complex

[Term]
id: GO:0070387
name: procollagen-proline 4-dioxygenase complex, alpha(II) type
namespace: cellular_component
def: "A procollagen-proline 4-dioxygenase complex that contains alpha subunits of the type II isoform; its activity is inhibited by poly(L-proline) only at high concentrations." [PMID:14500733, PMID:7753822]
synonym: "procollagen-proline, 2-oxoglutarate-4-dioxygenase complex, alpha(II) type" EXACT [PMID:7753822]
synonym: "prolyl 4-hydroxylase complex (alpha(II)-type)" BROAD [CORUM:473]
is_a: GO:0016222 ! procollagen-proline 4-dioxygenase complex

[Term]
id: GO:0070388
name: procollagen-proline 4-dioxygenase complex, alpha(III) type
namespace: cellular_component
def: "A procollagen-proline 4-dioxygenase complex that contains alpha subunits of the type III isoform." [PMID:14500733]
synonym: "procollagen-proline, 2-oxoglutarate-4-dioxygenase complex, alpha(III) type" EXACT [PMID:14500733]
synonym: "prolyl 4-hydroxylase complex (alpha(III)-type)" BROAD [CORUM:474]
is_a: GO:0016222 ! procollagen-proline 4-dioxygenase complex

[Term]
id: GO:0070389
name: chaperone cofactor-dependent protein refolding
namespace: biological_process
def: "The process of assisting in the restoration of the biological activity of an unfolded or misfolded protein, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release." [GOC:mah, GOC:rb]
subset: gosubset_prok
synonym: "chaperone co-factor-dependent protein refolding" EXACT []
is_a: GO:0042026 ! protein refolding
is_a: GO:0061077 ! chaperone-mediated protein folding

[Term]
id: GO:0070390
name: transcription export complex 2
namespace: cellular_component
def: "A protein complex that couples SAGA-dependent gene expression to mRNA export at the inner side of the nuclear pore complex (NPC). The TREX-2 complex is tethered to the inner side of the NPC via the nucleoporins Nup1 and Nup60; in S. cerevisiae it contains Sac3p, Thp1p, Sus1p and Cdc31p." [GOC:dgf, GOC:mah, PMID:17786152]
synonym: "Sac3-Thp1-Sus1-Cdc31 complex" EXACT [PMID:17786152]
synonym: "TREX-2 complex" EXACT [GOC:dgf]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0070391
name: response to lipoteichoic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoteichoic acid stimulus; lipoteichoic acid is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor." [GOC:add, PMID:14665680, PMID:16020688]
synonym: "response to LTA" EXACT [GOC:add]
is_a: GO:0002237 ! response to molecule of bacterial origin
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0070392
name: detection of lipoteichoic acid
namespace: biological_process
def: "The series of events in which a lipoteichoic acid stimulus is received by a cell and converted into a molecular signal; lipoteichoic acid is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor." [GOC:add, PMID:14665680, PMID:16020688]
synonym: "detection of LTA" EXACT [GOC:add]
is_a: GO:0032490 ! detection of molecule of bacterial origin
is_a: GO:0070391 ! response to lipoteichoic acid

[Term]
id: GO:0070393
name: teichoic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of teichoic acid, which is a major component of the cell wall of Gram-positive bacteria and typically consists of a polymer of glycerol-phosphate or ribitol-phosphate to which are attached glycosyl and D-alanyl ester residues." [GOC:add, PMID:14665680]
synonym: "teichoic acid breakdown" EXACT [GOC:add]
synonym: "teichoic acid catabolism" EXACT [GOC:add]
synonym: "teichoic acid degradation" EXACT [GOC:add]
is_a: GO:0009057 ! macromolecule catabolic process
is_a: GO:0046374 ! teichoic acid metabolic process
is_a: GO:1901136 ! carbohydrate derivative catabolic process

[Term]
id: GO:0070394
name: lipoteichoic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lipoteichoic acid, which is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor." [GOC:add, PMID:14665680, PMID:16020688]
synonym: "lipoteichoic acid metabolism" EXACT [GOC:add]
synonym: "LTA metabolic process" EXACT [GOC:add]
is_a: GO:0046374 ! teichoic acid metabolic process

[Term]
id: GO:0070395
name: lipoteichoic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lipoteichoic acid, which is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor." [GOC:add, PMID:14665680, PMID:16020688]
synonym: "lipoteichoic acid anabolism" EXACT [GOC:add]
synonym: "lipoteichoic acid biosynthesis" EXACT [GOC:add]
synonym: "lipoteichoic acid formation" EXACT [GOC:add]
synonym: "lipoteichoic acid synthesis" EXACT [GOC:add]
synonym: "LTA biosynthetic process" BROAD [GOC:add]
is_a: GO:0019350 ! teichoic acid biosynthetic process
is_a: GO:0070394 ! lipoteichoic acid metabolic process

[Term]
id: GO:0070396
name: lipoteichoic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lipoteichoic acid, which is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor." [GOC:add, PMID:14665680]
synonym: "lipoteichoic acid breakdown" EXACT [GOC:add]
synonym: "lipoteichoic acid catabolism" EXACT [GOC:add]
synonym: "lipoteichoic acid degradation" EXACT [GOC:add]
is_a: GO:0070393 ! teichoic acid catabolic process
is_a: GO:0070394 ! lipoteichoic acid metabolic process

[Term]
id: GO:0070397
name: wall teichoic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving wall teichoic acid, which is a major component of the cell wall of Gram-positive bacteria and typically consists of a polymer of glycerol-phosphate or ribitol-phosphate to which are attached glycosyl and D-alanyl ester residues and which is covalently linked to peptidoglycan." [GOC:add, PMID:14665680, PMID:16020688]
synonym: "wall teichoic acid metabolism" EXACT [GOC:add]
synonym: "WTA metabolic process" EXACT [GOC:add]
is_a: GO:0046374 ! teichoic acid metabolic process

[Term]
id: GO:0070398
name: wall teichoic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of wall teichoic acid, which is a major component of the cell wall of Gram-positive bacteria and typically consists of a polymer of glycerol-phosphate or ribitol-phosphate to which are attached glycosyl and D-alanyl ester residues and which is covalently linked to peptidoglycan." [GOC:add, PMID:14665680, PMID:16020688]
synonym: "wall teichoic acid anabolism" EXACT [GOC:add]
synonym: "wall teichoic acid biosynthesis" EXACT [GOC:add]
synonym: "wall teichoic acid formation" EXACT [GOC:add]
synonym: "wall teichoic acid synthesis" EXACT [GOC:add]
synonym: "WTA biosynthetic process" EXACT [GOC:add]
is_a: GO:0019350 ! teichoic acid biosynthetic process
is_a: GO:0070397 ! wall teichoic acid metabolic process

[Term]
id: GO:0070399
name: wall teichoic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of wall teichoic acid, which is a major component of the cell wall of Gram-positive bacteria and typically consists of a polymer of glycerol-phosphate or ribitol-phosphate to which are attached glycosyl and D-alanyl ester residues and which is covalently linked to peptidoglycan." [GOC:add, PMID:14665680]
synonym: "wall teichoic acid breakdown" EXACT [GOC:add]
synonym: "wall teichoic acid catabolism" EXACT [GOC:add]
synonym: "wall teichoic acid degradation" EXACT [GOC:add]
is_a: GO:0070397 ! wall teichoic acid metabolic process

[Term]
id: GO:0070400
name: teichoic acid D-alanylation
namespace: biological_process
def: "The formation of a D-alanyl ester of teichoic acid. Alanylation of teichoic acids modulates the properties of the bacterial cell wall and modulates the inflammatory properties of the teichoic acid." [GOC:add, PMID:14665680, PMID:16020688]
synonym: "teichoic acid alanylation" EXACT [GOC:add]
is_a: GO:0019350 ! teichoic acid biosynthetic process

[Term]
id: GO:0070401
name: NADP+ binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the oxidized form, NADP+, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah]
synonym: "NADP (oxidized) binding" EXACT [GOC:mah]
synonym: "NADP binding" RELATED [GOC:mah]
synonym: "oxidized NADP binding" EXACT [GOC:mah]
synonym: "oxidized nicotinamide adenine dinucleotide phosphate binding" EXACT [GOC:mah]
is_a: GO:0043168 ! anion binding
is_a: GO:0050661 ! NADP binding

[Term]
id: GO:0070402
name: NADPH binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah]
synonym: "NADP (reduced) binding" EXACT [GOC:mah]
synonym: "reduced NADP binding" EXACT [GOC:mah]
synonym: "reduced nicotinamide adenine dinucleotide phosphate binding" EXACT [GOC:mah]
is_a: GO:0043168 ! anion binding
is_a: GO:0050661 ! NADP binding

[Term]
id: GO:0070403
name: NAD+ binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah]
synonym: "NAD (oxidized) binding" EXACT [GOC:mah]
synonym: "NAD binding" RELATED [GOC:mah]
synonym: "oxidized NAD binding" EXACT [GOC:mah]
synonym: "oxidized nicotinamide adenine dinucleotide binding" EXACT [GOC:mah]
is_a: GO:0043168 ! anion binding
is_a: GO:0051287 ! NAD binding

[Term]
id: GO:0070404
name: NADH binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the reduced form, NADH, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah]
synonym: "NAD (reduced) binding" EXACT [GOC:mah]
synonym: "reduced NAD binding" EXACT [GOC:mah]
synonym: "reduced nicotinamide adenine dinucleotide binding" EXACT [GOC:mah]
is_a: GO:0043168 ! anion binding
is_a: GO:0051287 ! NAD binding

[Term]
id: GO:0070405
name: ammonium ion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with ammonium ions (NH4+)." [CHEBI:28938, GOC:ecd]
synonym: "ammonium binding" RELATED []
is_a: GO:0043169 ! cation binding

[Term]
id: GO:0070406
name: glutamine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with glutamine, 2,5-diamino-5-oxopentanoic acid." [CHEBI:28300, GOC:ecd]
is_a: GO:0016597 ! amino acid binding
is_a: GO:0043169 ! cation binding

[Term]
id: GO:0070407
name: oxidation-dependent protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the oxidation of one or more amino acid residues in the protein." [GOC:mah]
synonym: "oxidation-dependent protein breakdown" EXACT [GOC:mah]
synonym: "oxidation-dependent protein catabolism" EXACT [GOC:mah]
synonym: "oxidation-dependent protein degradation" EXACT [GOC:mah]
synonym: "oxidation-dependent proteolysis" EXACT [GOC:mah]
synonym: "oxidized protein catabolic process" EXACT [GOC:mah]
is_a: GO:0019941 ! modification-dependent protein catabolic process

[Term]
id: GO:0070408
name: carbamoyl phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving carbamoyl phosphate, an intermediate in the urea cycle and other nitrogen compound metabolic pathways." [CHEBI:17672, GOC:mah, GOC:rph]
synonym: "carbamoyl phosphate metabolism" EXACT [GOC:mah]
xref: UM-BBD_pathwayID:bzn
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:0034641 ! cellular nitrogen compound metabolic process

[Term]
id: GO:0070409
name: carbamoyl phosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of carbamoyl phosphate, an intermediate in the urea cycle and other nitrogen compound metabolic pathways." [CHEBI:17672, GOC:mah, GOC:rph]
subset: gosubset_prok
synonym: "carbamoyl phosphate anabolism" EXACT []
synonym: "carbamoyl phosphate biosynthesis" EXACT []
synonym: "carbamoyl phosphate formation" EXACT []
synonym: "carbamoyl phosphate synthesis" EXACT []
synonym: "carbamyl phosphate biosynthetic process" EXACT [GOC:rph]
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process
is_a: GO:0070408 ! carbamoyl phosphate metabolic process
is_a: GO:0090407 ! organophosphate biosynthetic process

[Term]
id: GO:0070410
name: co-SMAD binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a common mediator SMAD signaling protein." [GOC:BHF, GOC:vk, PMID:19114992]
is_a: GO:0046332 ! SMAD binding

[Term]
id: GO:0070411
name: I-SMAD binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an inhibitory SMAD signaling protein." [GOC:BHF, GOC:vk, PMID:19114992]
is_a: GO:0046332 ! SMAD binding

[Term]
id: GO:0070412
name: R-SMAD binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a receptor-regulated SMAD signaling protein." [GOC:BHF, GOC:vk, PMID:19114992]
is_a: GO:0046332 ! SMAD binding

[Term]
id: GO:0070413
name: trehalose metabolism in response to stress
namespace: biological_process
def: "The chemical reactions and pathways involving trehalose that occur as a result of a stimulus indicating the organism is under stress." [GOC:jp, GOC:mah, PMID:9797333]
synonym: "trehalose metabolic process involved in response to stress" EXACT systematic_synonym [GOC:mah]
is_a: GO:0005991 ! trehalose metabolic process
intersection_of: GO:0005991 ! trehalose metabolic process
intersection_of: part_of GO:0006950 ! response to stress
relationship: part_of GO:0006950 ! response to stress
relationship: part_of GO:0033554 ! cellular response to stress

[Term]
id: GO:0070414
name: trehalose metabolism in response to heat stress
namespace: biological_process
def: "The chemical reactions and pathways involving trehalose that occur as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:jp, GOC:mah, PMID:9797333]
synonym: "trehalose metabolic process involved in response to heat stress" EXACT systematic_synonym [GOC:mah]
is_a: GO:0070413 ! trehalose metabolism in response to stress
relationship: part_of GO:0034605 ! cellular response to heat

[Term]
id: GO:0070415
name: trehalose metabolism in response to cold stress
namespace: biological_process
def: "The chemical reactions and pathways involving trehalose that occur as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism." [GOC:jp, GOC:mah, PMID:9797333]
synonym: "trehalose metabolic process involved in response to cold stress" EXACT systematic_synonym [GOC:mah]
is_a: GO:0070413 ! trehalose metabolism in response to stress
is_a: GO:0070417 ! cellular response to cold

[Term]
id: GO:0070416
name: trehalose metabolism in response to water deprivation
namespace: biological_process
def: "The chemical reactions and pathways involving trehalose that occur as a result of deprivation of water." [GOC:jp, GOC:mah, PMID:9797333]
synonym: "trehalose metabolic process involved in response to water deprivation" EXACT systematic_synonym [GOC:mah]
is_a: GO:0070413 ! trehalose metabolism in response to stress
intersection_of: GO:0005991 ! trehalose metabolic process
intersection_of: part_of GO:0009414 ! response to water deprivation
relationship: part_of GO:0009414 ! response to water deprivation

[Term]
id: GO:0070417
name: cellular response to cold
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism." [GOC:jp]
synonym: "cellular response to cold stress" EXACT [GOC:jp]
is_a: GO:0009409 ! response to cold
is_a: GO:0033554 ! cellular response to stress

[Term]
id: GO:0070418
name: DNA-dependent protein kinase complex
namespace: cellular_component
def: "A protein complex that is involved in the repair of DNA double-strand breaks and, in mammals, V(D)J recombination events. It consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and the DNA end-binding heterodimer Ku." [GOC:mah, PMID:10854421, PMID:12235392]
synonym: "DNA-dependent protein kinase, DNA-end-binding complex" NARROW []
synonym: "DNA-PK complex" EXACT []
synonym: "DNA-PK-Ku antigen complex" EXACT [CORUM:355]
is_a: GO:0044428 ! nuclear part
is_a: GO:1902554 ! serine/threonine protein kinase complex

[Term]
id: GO:0070419
name: nonhomologous end joining complex
namespace: cellular_component
def: "A protein complex that plays a role in DNA double-strand break repair via nonhomologous end joining. Such complexes typically contain a specialized DNA ligase (e.g. Lig4 in eukaryotes) and one or more proteins that bind to DNA ends." [GOC:mah, PMID:17072889, PMID:17938628]
synonym: "NHEJ complex" EXACT [GOC:mah]
synonym: "non-homologous end joining complex" EXACT [GOC:mah]
is_a: GO:0044424 ! intracellular part
is_a: GO:1990391 ! DNA repair complex

[Term]
id: GO:0070420
name: Ku-DNA ligase complex
namespace: cellular_component
def: "A nonhomologous end joining complex that contains one or more Ku monomers and one or more DNA ligase molecules from the LigC or LigD family, and mediates nonhomologous end joining in bacteria." [GOC:mah, PMID:17938628]
is_a: GO:0070419 ! nonhomologous end joining complex

[Term]
id: GO:0070421
name: DNA ligase III-XRCC1 complex
namespace: cellular_component
def: "A protein complex that contains DNA ligase III and XRCC1, and is involved in base excision repair." [PMID:15141024, PMID:7760816]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0070422
name: G-protein beta/gamma-Raf-1 complex
namespace: cellular_component
def: "A protein complex formed by the association of the serine-threonine protein kinase Raf-1 with the beta and gamma subunits of a heterotrimeric G protein." [GOC:mah, PMID:7782277]
comment: See also the cellular component term 'heterotrimeric G-protein complex ; GO:0005834'.
synonym: "G protein complex (GNG2, GNB2L1, RAF1)" RELATED [CORUM:1539]
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0070423
name: nucleotide-binding oligomerization domain containing signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to a nucleotide-binding oligomerization domain containing (NOD) protein." [GOC:add, PMID:17944960, PMID:18585455]
synonym: "NOD signaling pathway" EXACT [GOC:add]
synonym: "nucleotide-binding oligomerization domain containing signalling pathway" EXACT [GOC:mah]
xref: Reactome:REACT_107510 "NOD1/2 Signaling Pathway, Gallus gallus"
xref: Reactome:REACT_107554 "NOD1/2 Signaling Pathway, Sus scrofa"
xref: Reactome:REACT_109847 "NOD1/2 Signaling Pathway, Xenopus tropicalis"
xref: Reactome:REACT_112657 "NOD1/2 Signaling Pathway, Drosophila melanogaster"
xref: Reactome:REACT_75776 "NOD1/2 Signaling Pathway, Homo sapiens"
xref: Reactome:REACT_88024 "NOD1/2 Signaling Pathway, Mus musculus"
xref: Reactome:REACT_88153 "NOD1/2 Signaling Pathway, Bos taurus"
xref: Reactome:REACT_89333 "NOD1/2 Signaling Pathway, Canis familiaris"
xref: Reactome:REACT_89606 "NOD1/2 Signaling Pathway, Danio rerio"
xref: Reactome:REACT_96245 "NOD1/2 Signaling Pathway, Rattus norvegicus"
xref: Reactome:REACT_96520 "NOD1/2 Signaling Pathway, Taeniopygia guttata"
is_a: GO:0002753 ! cytoplasmic pattern recognition receptor signaling pathway
is_a: GO:0035872 ! nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway

[Term]
id: GO:0070424
name: regulation of nucleotide-binding oligomerization domain containing signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a nucleotide-binding oligomerization domain containing (NOD) pathway." [GOC:add]
synonym: "regulation of NOD signaling pathway" EXACT [GOC:add]
synonym: "regulation of nucleotide-binding oligomerization domain containing signalling pathway" EXACT [GOC:mah]
is_a: GO:0045088 ! regulation of innate immune response
is_a: GO:1902531 ! regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070423 ! nucleotide-binding oligomerization domain containing signaling pathway
relationship: regulates GO:0070423 ! nucleotide-binding oligomerization domain containing signaling pathway

[Term]
id: GO:0070425
name: negative regulation of nucleotide-binding oligomerization domain containing signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing (NOD) pathway." [GOC:add]
synonym: "negative regulation of NOD signaling pathway" EXACT [GOC:add]
synonym: "negative regulation of nucleotide-binding oligomerization domain containing signalling pathway" EXACT [GOC:mah]
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0070424 ! regulation of nucleotide-binding oligomerization domain containing signaling pathway
is_a: GO:1902532 ! negative regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070423 ! nucleotide-binding oligomerization domain containing signaling pathway
relationship: negatively_regulates GO:0070423 ! nucleotide-binding oligomerization domain containing signaling pathway

[Term]
id: GO:0070426
name: positive regulation of nucleotide-binding oligomerization domain containing signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing (NOD) pathway." [GOC:add]
synonym: "positive regulation of NOD signaling pathway" EXACT [GOC:add]
synonym: "positive regulation of nucleotide-binding oligomerization domain containing signalling pathway" EXACT [GOC:mah]
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0070424 ! regulation of nucleotide-binding oligomerization domain containing signaling pathway
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070423 ! nucleotide-binding oligomerization domain containing signaling pathway
relationship: positively_regulates GO:0070423 ! nucleotide-binding oligomerization domain containing signaling pathway

[Term]
id: GO:0070427
name: nucleotide-binding oligomerization domain containing 1 signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to nucleotide-binding oligomerization domain containing 1 (NOD1)." [GOC:add, PMID:17944960, PMID:18585455]
synonym: "NOD1 signaling pathway" EXACT [GOC:add]
synonym: "nucleotide-binding oligomerization domain containing 1 signalling pathway" EXACT [GOC:mah]
is_a: GO:0070423 ! nucleotide-binding oligomerization domain containing signaling pathway

[Term]
id: GO:0070428
name: regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 1 (NOD1) pathway." [GOC:add]
synonym: "regulation of NOD1 signaling pathway" EXACT [GOC:add]
synonym: "regulation of nucleotide-binding oligomerization domain containing 1 signalling pathway" EXACT [GOC:mah]
is_a: GO:0070424 ! regulation of nucleotide-binding oligomerization domain containing signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070427 ! nucleotide-binding oligomerization domain containing 1 signaling pathway
relationship: regulates GO:0070427 ! nucleotide-binding oligomerization domain containing 1 signaling pathway

[Term]
id: GO:0070429
name: negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 1 (NOD1) pathway." [GOC:add]
synonym: "negative regulation of NOD1 signaling pathway" EXACT [GOC:add]
synonym: "negative regulation of nucleotide-binding oligomerization domain containing 1 signalling pathway" EXACT [GOC:mah]
is_a: GO:0070425 ! negative regulation of nucleotide-binding oligomerization domain containing signaling pathway
is_a: GO:0070428 ! regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070427 ! nucleotide-binding oligomerization domain containing 1 signaling pathway
relationship: negatively_regulates GO:0070427 ! nucleotide-binding oligomerization domain containing 1 signaling pathway

[Term]
id: GO:0070430
name: positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 1 (NOD1) pathway." [GOC:add]
synonym: "positive regulation of NOD1 signaling pathway" EXACT [GOC:add]
synonym: "positive regulation of nucleotide-binding oligomerization domain containing 1 signalling pathway" EXACT [GOC:mah]
is_a: GO:0070426 ! positive regulation of nucleotide-binding oligomerization domain containing signaling pathway
is_a: GO:0070428 ! regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070427 ! nucleotide-binding oligomerization domain containing 1 signaling pathway
relationship: positively_regulates GO:0070427 ! nucleotide-binding oligomerization domain containing 1 signaling pathway

[Term]
id: GO:0070431
name: nucleotide-binding oligomerization domain containing 2 signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to nucleotide-binding oligomerization domain containing 2 (NOD2)." [GOC:add, PMID:17944960, PMID:18585455]
synonym: "NOD2 signaling pathway" EXACT [GOC:add]
synonym: "nucleotide-binding oligomerization domain containing 2 signalling pathway" EXACT [GOC:mah]
is_a: GO:0070423 ! nucleotide-binding oligomerization domain containing signaling pathway

[Term]
id: GO:0070432
name: regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 2 (NOD2) pathway." [GOC:add]
synonym: "regulation of NOD2 signaling pathway" EXACT [GOC:add]
synonym: "regulation of nucleotide-binding oligomerization domain containing 2 signalling pathway" EXACT [GOC:mah]
is_a: GO:0070424 ! regulation of nucleotide-binding oligomerization domain containing signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070431 ! nucleotide-binding oligomerization domain containing 2 signaling pathway
relationship: regulates GO:0070431 ! nucleotide-binding oligomerization domain containing 2 signaling pathway

[Term]
id: GO:0070433
name: negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 2 (NOD2) pathway." [GOC:add]
synonym: "negative regulation of NOD2 signaling pathway" EXACT [GOC:add]
synonym: "negative regulation of nucleotide-binding oligomerization domain containing 2 signalling pathway" EXACT [GOC:mah]
is_a: GO:0070425 ! negative regulation of nucleotide-binding oligomerization domain containing signaling pathway
is_a: GO:0070432 ! regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070431 ! nucleotide-binding oligomerization domain containing 2 signaling pathway
relationship: negatively_regulates GO:0070431 ! nucleotide-binding oligomerization domain containing 2 signaling pathway

[Term]
id: GO:0070434
name: positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 2 (NOD2) pathway." [GOC:add]
synonym: "positive regulation of NOD2 signaling pathway" EXACT [GOC:add]
synonym: "positive regulation of nucleotide-binding oligomerization domain containing 2 signalling pathway" EXACT [GOC:mah]
is_a: GO:0070426 ! positive regulation of nucleotide-binding oligomerization domain containing signaling pathway
is_a: GO:0070432 ! regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070431 ! nucleotide-binding oligomerization domain containing 2 signaling pathway
relationship: positively_regulates GO:0070431 ! nucleotide-binding oligomerization domain containing 2 signaling pathway

[Term]
id: GO:0070435
name: Shc-EGFR complex
namespace: cellular_component
def: "A protein complex that contains the epidermal growth factor receptor (EGFR) and the adaptor protein Shc, and is involved in linking EGFR activation to the p21-Ras pathway." [GOC:mah, PMID:7798267]
synonym: "Shc-Egfr complex, EGF stimulated" NARROW [CORUM:2887]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070436
name: Grb2-EGFR complex
namespace: cellular_component
def: "A protein complex that contains the epidermal growth factor receptor (EGFR) and Grb2, and is involved in linking EGFR activation to the p21-Ras pathway." [GOC:mah, PMID:7798267]
synonym: "Grb2-Egfr complex, EGF stimulated" NARROW [CORUM:2889]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070437
name: Grb2-Shc complex
namespace: cellular_component
def: "A protein complex that contains Grb2 and the adaptor protein Shc, and is involved in linking epidermal growth factor receptor (EGFR) activation to the p21-Ras pathway." [GOC:mah, PMID:7798267]
synonym: "Grb2-Shc complex, EGF stimulated" NARROW [CORUM:2888]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070438
name: obsolete mTOR-FKBP12-rapamycin complex
namespace: cellular_component
def: "OBSOLETE. A protein complex that contains the mTOR (mammalian target of rapamycin) serine/threonine kinase, the peptidyl-prolyl cis-trans isomerase FKBP12 (FKBP1A) and rapamycin (sirolimus)." [GOC:sl, PMID:20005306, PMID:7822316]
comment: This term was made obsolete because it describes a complex with a drug bound, with the drug being exogenous to the species where the experiment takes place and where that interaction would never occur naturally.
synonym: "Fkbp1a-Frap1 complex" NARROW [CORUM:2987]
synonym: "mTOR-FKBP12-rapamycin complex" EXACT []
is_obsolete: true

[Term]
id: GO:0070439
name: Mad-Max-mSin3A complex
namespace: cellular_component
def: "A transcriptional repressor complex that contains a heterodimer of the bHLH-ZIP proteins Mad and Max, plus mSin3A, a homolog of the yeast Sin3p." [PMID:7889570]
is_a: GO:0090571 ! RNA polymerase II transcription repressor complex

[Term]
id: GO:0070440
name: Mad-Max-mSin3B complex
namespace: cellular_component
def: "A transcriptional repressor complex that contains a heterodimer of the bHLH-ZIP proteins Mad and Max, plus mSin3B, a homolog of the yeast Sin3p." [PMID:7889570]
is_a: GO:0090571 ! RNA polymerase II transcription repressor complex

[Term]
id: GO:0070441
name: G-protein beta/gamma-Btk complex
namespace: cellular_component
def: "A protein complex formed by the association of the Bruton tyrosine protein kinase Btk, which is implicated in mammalian X-linked immunodeficiencies, with the beta and gamma subunits of a heterotrimeric G protein." [GOC:mah, PMID:7972043]
comment: See also the cellular component term 'heterotrimeric G-protein complex ; GO:0005834'.
synonym: "G protein complex (BTK, GNG1, GNG2)" RELATED [CORUM:1615]
synonym: "G protein complex (Btk, Gng2, Gnb1)" RELATED [CORUM:3195]
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0070442
name: integrin alphaIIb-beta3 complex
namespace: cellular_component
def: "An integrin complex that comprises one alphaIIb subunit and one beta3 subunit." [PMID:12297042]
synonym: "alphaIIb-beta3 integrin complex" EXACT []
synonym: "ITGA2B-ITGB3 complex" NARROW [CORUM:2381]
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0070443
name: Mad-Max complex
namespace: cellular_component
def: "A transcriptional repressor complex that consists of a heterodimer of the bHLH-ZIP proteins Mad and Max." [PMID:8224841]
is_a: GO:0090571 ! RNA polymerase II transcription repressor complex

[Term]
id: GO:0070444
name: oligodendrocyte progenitor proliferation
namespace: biological_process
def: "The multiplication or reproduction of oligodendrocyte progenitor cells by cell division, resulting in the expansion of their population. Oligodendrocyte progenitors give rise to oligodendrocytes, which form the insulating myelin sheath of axons in the central nervous system." [GOC:mah, GOC:sl, PMID:15504915]
synonym: "oligodendrocyte precursor proliferation" EXACT [GOC:mah]
is_a: GO:0061351 ! neural precursor cell proliferation
relationship: part_of GO:0042063 ! gliogenesis

[Term]
id: GO:0070445
name: regulation of oligodendrocyte progenitor proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of oligodendrocyte progenitor proliferation." [GOC:mah, GOC:sl]
synonym: "regulation of oligodendrocyte precursor proliferation" EXACT [GOC:mah]
is_a: GO:0014013 ! regulation of gliogenesis
is_a: GO:2000177 ! regulation of neural precursor cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070444 ! oligodendrocyte progenitor proliferation
relationship: regulates GO:0070444 ! oligodendrocyte progenitor proliferation

[Term]
id: GO:0070446
name: negative regulation of oligodendrocyte progenitor proliferation
namespace: biological_process
def: "Any process that stops or decreases the rate or extent of oligodendrocyte progenitor proliferation." [GOC:mah, GOC:sl]
synonym: "negative regulation of oligodendrocyte precursor proliferation" EXACT [GOC:mah]
is_a: GO:0014014 ! negative regulation of gliogenesis
is_a: GO:0070445 ! regulation of oligodendrocyte progenitor proliferation
is_a: GO:2000178 ! negative regulation of neural precursor cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070444 ! oligodendrocyte progenitor proliferation
relationship: negatively_regulates GO:0070444 ! oligodendrocyte progenitor proliferation

[Term]
id: GO:0070447
name: positive regulation of oligodendrocyte progenitor proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of oligodendrocyte progenitor proliferation." [GOC:mah, GOC:sl]
synonym: "positive regulation of oligodendrocyte precursor proliferation" EXACT [GOC:mah]
is_a: GO:0014015 ! positive regulation of gliogenesis
is_a: GO:0070445 ! regulation of oligodendrocyte progenitor proliferation
is_a: GO:2000179 ! positive regulation of neural precursor cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070444 ! oligodendrocyte progenitor proliferation
relationship: positively_regulates GO:0070444 ! oligodendrocyte progenitor proliferation

[Term]
id: GO:0070448
name: laricitrin 5'-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + laricitrin = S-adenosyl-L-homocysteine + syringetin." [MetaCyc:RXN-8452]
comment: Note that this term represents one of two reactions that are grouped together in EC 2.1.1.149.
synonym: "CrCOMT2" RELATED [EC:2.1.1.149]
synonym: "flavonoid 3',5'-O-dimethyltransferase activity" RELATED [EC:2.1.1.149]
synonym: "S-adenosyl-L-methionine:myricetin O-methyltransferase activity" RELATED [EC:2.1.1.149]
xref: EC:2.1.1.149
xref: KEGG:R06816
xref: MetaCyc:RXN-8452
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0070449
name: elongin complex
namespace: cellular_component
def: "A transcription elongation factor complex that suppresses RNA polymerase II pausing, and may act by promoting proper alignment of the 3'-end of nascent transcripts with the polymerase catalytic site. Consists of a transcriptionally active Elongin A subunit (abut 100 kDa)and two smaller Elongin B (about 18 kDa) and Elongin C (about 15 kDa)subunits." [PMID:12676794]
comment: See also the cellular component terms 'cyclin-dependent protein kinase activating kinase holoenzyme complex ; GO:0019907' and 'DNA-directed RNA polymerase II, holoenzyme ; GO:0016591'.
synonym: "elongin (SIII) complex" EXACT [CORUM:56]
synonym: "transcription elongation factor SIII complex" EXACT [PMID:8244996]
is_a: GO:0008023 ! transcription elongation factor complex

[Term]
id: GO:0070450
name: interleukin4-interleukin-4 receptor complex
namespace: cellular_component
def: "A protein complex that is formed by the association of a heterodimeric interleukin-4 receptor complex with an interleukin-4 molecule." [GOC:mah, PMID:10358772]
subset: goslim_pir
synonym: "IL4-IL4 receptor complex" EXACT [GOC:mah]
synonym: "IL4-IL4R-IL2RG complex" NARROW [CORUM:1515]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070451
name: cell hair
namespace: cellular_component
def: "A long, thin cell projection that contains F-actin and tubulin, with microtubules centrally located and F-actin peripherally located." [PMID:11526084]
subset: goslim_pir
synonym: "imaginal disc-derived wing hair" NARROW [GOC:mah]
synonym: "non-sensory hair" EXACT [GOC:bf]
xref: Wikipedia:Membrane_nanotube
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0070452
name: positive regulation of ergosterol biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ergosterol." [GOC:mah]
synonym: "activation of ergosterol biosynthetic process" NARROW []
synonym: "positive regulation of ergosterol anabolism" EXACT []
synonym: "positive regulation of ergosterol biosynthesis" EXACT []
synonym: "positive regulation of ergosterol formation" EXACT []
synonym: "positive regulation of ergosterol synthesis" EXACT []
synonym: "stimulation of ergosterol biosynthetic process" NARROW []
synonym: "up regulation of ergosterol biosynthetic process" EXACT []
synonym: "up-regulation of ergosterol biosynthetic process" EXACT []
synonym: "upregulation of ergosterol biosynthetic process" EXACT []
is_a: GO:0010893 ! positive regulation of steroid biosynthetic process
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0032443 ! regulation of ergosterol biosynthetic process
is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006696 ! ergosterol biosynthetic process
relationship: positively_regulates GO:0006696 ! ergosterol biosynthetic process

[Term]
id: GO:0070453
name: regulation of heme biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of heme." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of haem biosynthesis" EXACT [GOC:mah]
synonym: "regulation of haem biosynthetic process" EXACT [GOC:mah]
synonym: "regulation of heme anabolism" EXACT [GOC:mah]
synonym: "regulation of heme biosynthesis" EXACT [GOC:mah]
synonym: "regulation of heme formation" EXACT [GOC:mah]
synonym: "regulation of heme synthesis" EXACT [GOC:mah]
is_a: GO:0051193 ! regulation of cofactor metabolic process
is_a: GO:1901463 ! regulation of tetrapyrrole biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006783 ! heme biosynthetic process
relationship: regulates GO:0006783 ! heme biosynthetic process

[Term]
id: GO:0070454
name: negative regulation of heme biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of heme." [GOC:mah]
synonym: "down regulation of heme biosynthetic process" EXACT [GOC:mah]
synonym: "down-regulation of heme biosynthetic process" EXACT [GOC:mah]
synonym: "downregulation of heme biosynthetic process" EXACT [GOC:mah]
synonym: "inhibition of heme biosynthetic process" NARROW [GOC:mah]
synonym: "negative regulation of haem biosynthetic process" EXACT [GOC:mah]
synonym: "negative regulation of heme anabolism" EXACT [GOC:mah]
synonym: "negative regulation of heme biosynthesis" EXACT [GOC:mah]
synonym: "negative regulation of heme formation" EXACT [GOC:mah]
synonym: "negative regulation of heme synthesis" EXACT [GOC:mah]
is_a: GO:0051195 ! negative regulation of cofactor metabolic process
is_a: GO:0070453 ! regulation of heme biosynthetic process
is_a: GO:1901464 ! negative regulation of tetrapyrrole biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006783 ! heme biosynthetic process
relationship: negatively_regulates GO:0006783 ! heme biosynthetic process

[Term]
id: GO:0070455
name: positive regulation of heme biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of heme." [GOC:mah]
synonym: "activation of heme biosynthetic process" NARROW [GOC:mah]
synonym: "positive regulation of haem biosynthetic process" EXACT [GOC:mah]
synonym: "positive regulation of heme anabolism" EXACT [GOC:mah]
synonym: "positive regulation of heme biosynthesis" EXACT [GOC:mah]
synonym: "positive regulation of heme formation" EXACT [GOC:mah]
synonym: "positive regulation of heme synthesis" EXACT [GOC:mah]
synonym: "stimulation of heme biosynthetic process" NARROW [GOC:mah]
synonym: "up regulation of heme biosynthetic process" EXACT [GOC:mah]
synonym: "up-regulation of heme biosynthetic process" EXACT [GOC:mah]
synonym: "upregulation of heme biosynthetic process" EXACT [GOC:mah]
is_a: GO:0051194 ! positive regulation of cofactor metabolic process
is_a: GO:0070453 ! regulation of heme biosynthetic process
is_a: GO:1901465 ! positive regulation of tetrapyrrole biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006783 ! heme biosynthetic process
relationship: positively_regulates GO:0006783 ! heme biosynthetic process

[Term]
id: GO:0070456
name: galactose-1-phosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: galactose-1-phosphate + H2O = galactose + phosphate." [GOC:mah]
is_a: GO:0050308 ! sugar-phosphatase activity

[Term]
id: GO:0070457
name: D-galactose-1-phosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-galactose-1-phosphate + H2O = D-galactose + phosphate." [GOC:mah, PMID:9462881]
is_a: GO:0070456 ! galactose-1-phosphate phosphatase activity

[Term]
id: GO:0070458
name: cellular detoxification of nitrogen compound
namespace: biological_process
def: "Any cellular process that reduces or removes the toxicity of nitrogenous compounds which are dangerous or toxic. This includes the aerobic conversion of toxic compounds to harmless substances." [GOC:mah]
synonym: "cellular detoxification of nitrogenous compound" EXACT [GOC:mah]
is_a: GO:0044710 ! single-organism metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0051410 ! detoxification of nitrogen compound
is_a: GO:1990748 ! cellular detoxification
relationship: part_of GO:0033554 ! cellular response to stress

[Term]
id: GO:0070459
name: prolactin secretion
namespace: biological_process
def: "The regulated release of prolactin, a peptide hormone that stimulates lactation, from secretory granules in the anterior pituitary." [GOC:mah, ISBN:0198506732]
is_a: GO:0009306 ! protein secretion
is_a: GO:0030072 ! peptide hormone secretion

[Term]
id: GO:0070460
name: thyroid-stimulating hormone secretion
namespace: biological_process
def: "The regulated release of thyroid-stimulating hormone, a peptide hormone that stimulates the activity of the thyroid gland, from secretory granules in the anterior pituitary." [GOC:mah, ISBN:0198506732]
synonym: "thyroid stimulating hormone secretion" EXACT [GOC:mah]
synonym: "TSH secretion" EXACT []
is_a: GO:0030072 ! peptide hormone secretion

[Term]
id: GO:0070461
name: SAGA-type complex
namespace: cellular_component
def: "A histone acetyltransferase complex that acetylates nucleosomal H3 and H2B and is required for the expression of a subset of Pol II-transcribed genes. The budding yeast complex includes the acetyltransferase Gcn5p, several proteins of the Spt and Ada families, and several TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins." [GOC:mah, PMID:10637607, PMID:17337012]
synonym: "SAGA family complex" EXACT [PMID:17337012]
is_a: GO:0000123 ! histone acetyltransferase complex

[Term]
id: GO:0070462
name: plus-end specific microtubule depolymerization
namespace: biological_process
def: "The removal of tubulin heterodimers from the plus end of a microtubule." [GOC:krc, PMID:16906145, PMID:16906148]
is_a: GO:0007019 ! microtubule depolymerization

[Term]
id: GO:0070463
name: tubulin-dependent ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of a tubulin dimer to accelerate release of ADP and phosphate." [GOC:mah, PMID:16906148]
synonym: "tubulin-activated ATPase activity" EXACT []
is_a: GO:0042623 ! ATPase activity, coupled

[Term]
id: GO:0070464
name: alphav-beta3 integrin-collagen alpha3(VI) complex
namespace: cellular_component
def: "A protein complex that consists of an alphav-beta3 integrin complex bound to the alpha3 chain of type VI collagen; the integrin binds most strongly to unfolded collagen." [PMID:8387021]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070465
name: alpha1-beta1 integrin-alpha3(VI) complex
namespace: cellular_component
def: "A protein complex that consists of an alpha1-beta1 integrin complex bound to a type VI collagen triple helix containing an alpha3(VI) chain." [PMID:8387021]
synonym: "ITGA1-ITGB1-COL6A3 complex" NARROW [CORUM:2434]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070466
name: alpha2-beta1 integrin-alpha3(VI) complex
namespace: cellular_component
def: "A protein complex that consists of an alpha2-beta1 integrin complex bound to a type VI collagen triple helix containing an alpha3(VI) chain." [PMID:8387021]
synonym: "ITGA2-ITGB1-COL6A3 complex" NARROW [CORUM:2431]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070467
name: RC-1 DNA recombination complex
namespace: cellular_component
def: "A protein complex that contains DNA ligase III, DNA polymerase epsilon, a 5'-3' exonuclease, and the SMC1 and SMC2 proteins, and is involved in recombinational repair of deletions and gaps in DNA." [PMID:8392064, PMID:8670910]
synonym: "DNA recombination complex RC-1" EXACT [GOC:mah]
synonym: "RC-1 complex (recombination complex 1)" EXACT [CORUM:364]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0070468
name: dentin secretion
namespace: biological_process
def: "The regulated release by odontoblasts of the extracellular matrix constituents, including collagen, that form the basis of dentin." [GOC:mah, http://herkules.oulu.fi/isbn9514270355/html/i259726.html, PMID:12856968]
synonym: "dentine secretion" EXACT [GOC:mah]
synonym: "predentin secretion" EXACT [http://herkules.oulu.fi/isbn9514270355/html/i259726.html]
is_a: GO:0070278 ! extracellular matrix constituent secretion
relationship: part_of GO:0042475 ! odontogenesis of dentin-containing tooth

[Term]
id: GO:0070469
name: respiratory chain
namespace: cellular_component
def: "The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:ecd, GOC:mah, ISBN:0198547684]
subset: goslim_metagenomics
synonym: "membrane electron transport chain" EXACT [GOC:mah]
is_a: GO:0044425 ! membrane part

[Term]
id: GO:0070470
name: plasma membrane respiratory chain
namespace: cellular_component
def: "A respiratory chain located in the plasma membrane of a cell; made up of the protein complexes that form the electron transport system (the respiratory chain), associated with the plasma membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:curators, GOC:imk, GOC:mah, ISBN:0198547684]
synonym: "plasma membrane electron transport chain" EXACT [GOC:mah]
is_a: GO:0044459 ! plasma membrane part
is_a: GO:0070469 ! respiratory chain

[Term]
id: GO:0070471
name: uterine smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the uterus. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The uterus is a muscular organ of the female mammal for containing and usually for nourishing the young during development prior to birth." [GOC:sl]
synonym: "myometrial contraction" EXACT [GOC:sl]
synonym: "myometrial smooth muscle contraction" EXACT [GOC:sl]
synonym: "myometrium contraction" EXACT [GOC:sl]
is_a: GO:0006939 ! smooth muscle contraction

[Term]
id: GO:0070472
name: regulation of uterine smooth muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of uterine smooth muscle contraction." [GOC:go_curators]
synonym: "regulation of myometrial contraction" EXACT [GOC:sl]
synonym: "regulation of myometrial smooth muscle contraction" EXACT [GOC:sl]
synonym: "regulation of myometrium contraction" EXACT [GOC:sl]
is_a: GO:0006940 ! regulation of smooth muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070471 ! uterine smooth muscle contraction
relationship: regulates GO:0070471 ! uterine smooth muscle contraction

[Term]
id: GO:0070473
name: negative regulation of uterine smooth muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of uterine smooth muscle contraction." [GOC:go_curators]
synonym: "down regulation of uterine smooth muscle contraction" EXACT [GOC:mah]
synonym: "down-regulation of uterine smooth muscle contraction" EXACT [GOC:mah]
synonym: "downregulation of uterine smooth muscle contraction" EXACT [GOC:mah]
synonym: "inhibition of uterine smooth muscle contraction" NARROW [GOC:mah]
synonym: "negative regulation of myometrial contraction" EXACT [GOC:sl]
synonym: "negative regulation of myometrial smooth muscle contraction" EXACT [GOC:sl]
synonym: "negative regulation of myometrium contraction" EXACT [GOC:sl]
synonym: "uterine smooth muscle relaxation" RELATED [GOC:mah]
is_a: GO:0045986 ! negative regulation of smooth muscle contraction
is_a: GO:0070472 ! regulation of uterine smooth muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070471 ! uterine smooth muscle contraction
relationship: negatively_regulates GO:0070471 ! uterine smooth muscle contraction

[Term]
id: GO:0070474
name: positive regulation of uterine smooth muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of uterine smooth muscle contraction." [GOC:go_curators]
synonym: "activation of uterine smooth muscle contraction" NARROW [GOC:mah]
synonym: "positive regulation of myometrial contraction" EXACT [GOC:sl]
synonym: "positive regulation of myometrial smooth muscle contraction" EXACT [GOC:sl]
synonym: "positive regulation of myometrium contraction" EXACT [GOC:sl]
synonym: "stimulation of uterine smooth muscle contraction" NARROW [GOC:mah]
synonym: "up regulation of uterine smooth muscle contraction" EXACT [GOC:mah]
synonym: "up-regulation of uterine smooth muscle contraction" EXACT [GOC:mah]
synonym: "upregulation of uterine smooth muscle contraction" EXACT [GOC:mah]
is_a: GO:0045987 ! positive regulation of smooth muscle contraction
is_a: GO:0070472 ! regulation of uterine smooth muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070471 ! uterine smooth muscle contraction
relationship: positively_regulates GO:0070471 ! uterine smooth muscle contraction

[Term]
id: GO:0070475
name: rRNA base methylation
namespace: biological_process
def: "The addition of a methyl group to an atom in the nucleoside base portion of a nucleotide residue in an rRNA molecule." [GOC:mah]
is_a: GO:0031167 ! rRNA methylation

[Term]
id: GO:0070476
name: rRNA (guanine-N7)-methylation
namespace: biological_process
def: "The addition of a methyl group to the N7 atom in the base portion of a guanine nucleotide residue in an rRNA molecule." [GOC:mah]
is_a: GO:0036265 ! RNA (guanine-N7)-methylation
is_a: GO:0070475 ! rRNA base methylation

[Term]
id: GO:0070477
name: endospore core
namespace: cellular_component
def: "An intracellular part that represents the innermost portion of an endospore; the endospore core is dehydrated, enriched in dipicolinic acid and divalent cations, and metabolically inactive." [GOC:mah, PMID:15035041, PMID:18035610]
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0070478
name: nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the nuclear-transcribed mRNA transcript body of an mRNA in which an amino-acid codon has changed to a nonsense codon; occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction." [PMID:12769863]
synonym: "3'-5' NMD" EXACT [GOC:jp]
synonym: "3'-5' nonsense-mediated decay" EXACT [GOC:jp]
synonym: "3'-5' nonsense-mediated mRNA decay" EXACT [GOC:jp]
synonym: "nuclear-transcribed mRNA breakdown, 3'-5' exonucleolytic nonsense-mediated decay" EXACT [GOC:mah]
synonym: "nuclear-transcribed mRNA catabolism, 3'-5' exonucleolytic nonsense-mediated decay" EXACT [GOC:mah]
synonym: "nuclear-transcribed mRNA degradation, 3'-5' exonucleolytic nonsense-mediated decay" EXACT [GOC:mah]
is_a: GO:0000184 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
is_a: GO:0034427 ! nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
is_a: GO:0043928 ! exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay

[Term]
id: GO:0070479
name: nuclear-transcribed mRNA catabolic process, 5'-3' exonucleolytic nonsense-mediated decay
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the nuclear-transcribed mRNA transcript body of an mRNA in which an amino-acid codon has changed to a nonsense codon; occurs when the 5' end is not protected by a 5'-cap; degradation proceeds in the 5' to 3' direction." [PMID:18554525]
synonym: "5'-3' NMD" EXACT [GOC:jp]
synonym: "5'-3' nonsense-mediated decay" EXACT [GOC:jp]
synonym: "5'-3' nonsense-mediated mRNA decay" EXACT [GOC:jp]
synonym: "nuclear-transcribed mRNA breakdown, 5'-3' exonucleolytic nonsense-mediated decay" EXACT [GOC:mah]
synonym: "nuclear-transcribed mRNA catabolism, 5'-3' exonucleolytic nonsense-mediated decay" EXACT [GOC:mah]
synonym: "nuclear-transcribed mRNA degradation, 5'-3' exonucleolytic nonsense-mediated decay" EXACT [GOC:mah]
is_a: GO:0000184 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
is_a: GO:0034428 ! nuclear-transcribed mRNA catabolic process, exonucleolytic, 5'-3'
is_a: GO:0070480 ! exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-independent decay

[Term]
id: GO:0070480
name: exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-independent decay
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5'-cap." [GOC:jp]
synonym: "exonucleolytic nuclear-transcribed mRNA breakdown involved in deadenylation-independent decay" EXACT [GOC:mah]
synonym: "exonucleolytic nuclear-transcribed mRNA catabolism involved in deadenylation-independent decay" EXACT [GOC:mah]
synonym: "exonucleolytic nuclear-transcribed mRNA degradation involved in deadenylation-independent decay" EXACT [GOC:mah]
is_a: GO:0000291 ! nuclear-transcribed mRNA catabolic process, exonucleolytic
intersection_of: GO:0000291 ! nuclear-transcribed mRNA catabolic process, exonucleolytic
intersection_of: part_of GO:0031086 ! nuclear-transcribed mRNA catabolic process, deadenylation-independent decay
relationship: part_of GO:0031086 ! nuclear-transcribed mRNA catabolic process, deadenylation-independent decay

[Term]
id: GO:0070481
name: nuclear-transcribed mRNA catabolic process, non-stop decay
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that is lacking a stop codon." [PMID:11910110]
synonym: "non-stop decay" EXACT [GOC:jp]
synonym: "non-stop mRNA decay" EXACT [GOC:jp]
synonym: "nonstop mRNA decay" EXACT [GOC:jp]
synonym: "nuclear-transcribed mRNA breakdown, non-stop decay" EXACT [GOC:mah]
synonym: "nuclear-transcribed mRNA catabolism, non-stop decay" EXACT [GOC:mah]
synonym: "nuclear-transcribed mRNA degradation, non-stop decay" EXACT [GOC:mah]
is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process

[Term]
id: GO:0070482
name: response to oxygen levels
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:BHF, GOC:mah]
is_a: GO:0009628 ! response to abiotic stimulus

[Term]
id: GO:0070483
name: detection of hypoxia
namespace: biological_process
def: "The series of events in which a stimulus indicating lowered oxygen tension is received by a cell and converted into a molecular signal. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:BHF, GOC:mah]
synonym: "detection of reduced oxygen levels" EXACT [GOC:vk]
is_a: GO:0001666 ! response to hypoxia
is_a: GO:0003032 ! detection of oxygen

[Term]
id: GO:0070484
name: dehydro-D-arabinono-1,4-lactone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dehydro-D-arabinono-1,4-lactone, the gamma-lactone (5R)-3,4-dihydroxy-5-(hydroxymethyl)furan-2(5H)-one." [CHEBI:17803, GOC:cjk, GOC:mah]
synonym: "dehydro-D-arabinono-1,4-lactone metabolism" EXACT [GOC:mah]
is_a: GO:1901334 ! lactone metabolic process

[Term]
id: GO:0070485
name: dehydro-D-arabinono-1,4-lactone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dehydro-D-arabinono-1,4-lactone, the gamma-lactone (5R)-3,4-dihydroxy-5-(hydroxymethyl)furan-2(5H)-one." [CHEBI:17803, GOC:cjk, GOC:mah]
synonym: "dehydro-D-arabinono-1,4-lactone anabolism" EXACT [GOC:mah]
synonym: "dehydro-D-arabinono-1,4-lactone biosynthesis" EXACT [GOC:mah]
synonym: "dehydro-D-arabinono-1,4-lactone formation" EXACT [GOC:mah]
synonym: "dehydro-D-arabinono-1,4-lactone synthesis" EXACT [GOC:mah]
is_a: GO:0070484 ! dehydro-D-arabinono-1,4-lactone metabolic process
is_a: GO:1901336 ! lactone biosynthetic process

[Term]
id: GO:0070486
name: leukocyte aggregation
namespace: biological_process
def: "The adhesion of one leukocyte to one or more other leukocytes via adhesion molecules." [GOC:sl, PMID:12972508]
synonym: "immune cell aggregation" EXACT [CL:0000738]
synonym: "leucocyte aggregation" EXACT [CL:0000738, GOC:sl]
synonym: "white blood cell aggregation" EXACT [CL:0000738, GOC:sl]
synonym: "white corpuscle aggregation" EXACT [GOC:sl]
is_a: GO:0007159 ! leukocyte cell-cell adhesion

[Term]
id: GO:0070487
name: monocyte aggregation
namespace: biological_process
def: "The adhesion of one monocyte to one or more other monocytes via adhesion molecules." [GOC:sl, PMID:12972508]
synonym: "mononuclear phagocyte aggregation" EXACT [GOC:sl]
is_a: GO:0070486 ! leukocyte aggregation

[Term]
id: GO:0070488
name: neutrophil aggregation
namespace: biological_process
def: "The adhesion of one neutrophil to one or more other neutrophils via adhesion molecules." [GOC:sl, PMID:12972508]
synonym: "neutrocyte aggregation" EXACT [CL:0000775, GOC:mah]
synonym: "neutrophil leucocyte aggregation" EXACT [CL:0000775, GOC:mah]
synonym: "neutrophil leukocyte aggregation" EXACT [CL:0000775, GOC:mah]
synonym: "neutrophilic leucocyte aggregation" EXACT [CL:0000775, GOC:mah]
synonym: "neutrophilic leukocyte aggregation" EXACT [CL:0000775, GOC:mah]
is_a: GO:0070486 ! leukocyte aggregation

[Term]
id: GO:0070489
name: T cell aggregation
namespace: biological_process
def: "The adhesion of one T cell to one or more other T cells via adhesion molecules." [GOC:sl, PMID:12972508]
synonym: "T lymphocyte aggregation" EXACT [CL:0000084, GOC:sl]
synonym: "T-cell aggregation" EXACT [CL:0000084, GOC:mah]
synonym: "T-lymphocyte aggregation" EXACT [CL:0000084, GOC:mah]
is_a: GO:0045321 ! leukocyte activation
is_a: GO:0071593 ! lymphocyte aggregation

[Term]
id: GO:0070490
name: protein pupylation
namespace: biological_process
def: "The process in which a Pup protein is conjugated to a target protein via an isopeptide bond between the carboxyl terminus of Pup and the epsilon-amino group of a lysine residue of the target protein." [PMID:18980670]
synonym: "Pup-protein conjugation" EXACT [GOC:mah]
synonym: "pupylation" EXACT [GOC:mah]
is_a: GO:0018205 ! peptidyl-lysine modification
is_a: GO:0032446 ! protein modification by small protein conjugation

[Term]
id: GO:0070491
name: repressing transcription factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a transcription repressor, any protein whose activity is required to prevent or downregulate transcription." [GOC:mah, GOC:txnOH]
is_a: GO:0008134 ! transcription factor binding

[Term]
id: GO:0070492
name: oligosaccharide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]
subset: gosubset_prok
is_a: GO:0030246 ! carbohydrate binding

[Term]
id: GO:0070493
name: thrombin receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a thrombin receptor binding to one of its physiological ligands." [GOC:mah, PMID:1672265]
synonym: "thrombin receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0007186 ! G-protein coupled receptor signaling pathway

[Term]
id: GO:0070494
name: regulation of thrombin receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a thrombin receptor signaling pathway activity. A thrombin receptor signaling pathway is the series of molecular signals generated as a consequence of a thrombin receptor binding to one of its physiological ligands." [GOC:mah]
synonym: "regulation of thrombin receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070493 ! thrombin receptor signaling pathway
relationship: regulates GO:0070493 ! thrombin receptor signaling pathway

[Term]
id: GO:0070495
name: negative regulation of thrombin receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of thrombin receptor protein signaling pathway activity. A thrombin receptor signaling pathway is the series of molecular signals generated as a consequence of a thrombin receptor binding to one of its physiological ligands." [GOC:mah]
synonym: "negative regulation of thrombin receptor signalling pathway" RELATED [GOC:mah]
is_a: GO:0045744 ! negative regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:0070494 ! regulation of thrombin receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070493 ! thrombin receptor signaling pathway
relationship: negatively_regulates GO:0070493 ! thrombin receptor signaling pathway

[Term]
id: GO:0070496
name: positive regulation of thrombin receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of thrombin receptor protein signaling pathway activity. A thrombin receptor signaling pathway is the series of molecular signals generated as a consequence of a thrombin receptor binding to one of its physiological ligands." [GOC:mah]
synonym: "positive regulation of thrombin receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0045745 ! positive regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:0070494 ! regulation of thrombin receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070493 ! thrombin receptor signaling pathway
relationship: positively_regulates GO:0070493 ! thrombin receptor signaling pathway

[Term]
id: GO:0070497
name: 6-carboxy-5,6,7,8-tetrahydropterin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7,8-dihydroneopterin triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + triphosphate + acetaldehyde + 2 H+." [GOC:imk, MetaCyc:RXN0-5507, PMID:19231875]
xref: EC:4.2.1.-
xref: MetaCyc:RXN0-5507
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0070498
name: interleukin-1-mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of interleukin-1 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:mah, GOC:signaling]
synonym: "IL-1 alpha-mediated signaling pathway" NARROW [GOC:add]
synonym: "IL-1 beta-mediated signaling pathway" NARROW [GOC:add]
synonym: "IL-1-mediated signaling pathway" EXACT [GOC:mah]
synonym: "interleukin-1 alpha-mediated signaling pathway" NARROW [GOC:add]
synonym: "interleukin-1 beta-mediated signaling pathway" NARROW [GOC:add]
synonym: "interleukin-1-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0019221 ! cytokine-mediated signaling pathway
relationship: part_of GO:0071347 ! cellular response to interleukin-1

[Term]
id: GO:0070499
name: exosporium assembly
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the formation of an exosporium, the outermost layer of a bacterial endospore." [GOC:mah]
synonym: "exosporium formation" EXACT [GOC:mah]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0045229 ! external encapsulating structure organization

[Term]
id: GO:0070500
name: poly-gamma-glutamate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving poly-gamma-glutamate, a polymer of D- and/or L-glutamic acid residues linked by gamma-peptidyl bonds." [GOC:mah, PMID:16689787]
synonym: "poly-gamma-glutamate metabolism" EXACT [GOC:mah]
is_a: GO:0044260 ! cellular macromolecule metabolic process

[Term]
id: GO:0070501
name: poly-gamma-glutamate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of poly-gamma-glutamate, a polymer of D- and/or L-glutamic acid residues linked by gamma-peptidyl bonds." [GOC:mah, PMID:16689787]
synonym: "poly-gamma-glutamate anabolism" EXACT [GOC:mah]
synonym: "poly-gamma-glutamate biosynthesis" EXACT [GOC:mah]
synonym: "poly-gamma-glutamate formation" EXACT [GOC:mah]
synonym: "poly-gamma-glutamate synthesis" EXACT [GOC:mah]
is_a: GO:0034645 ! cellular macromolecule biosynthetic process
is_a: GO:0070500 ! poly-gamma-glutamate metabolic process

[Term]
id: GO:0070502
name: capsule poly-gamma-glutamate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of poly-gamma-glutamate, a polymer of D- and/or L-glutamic acid residues linked by gamma-peptidyl bonds, that forms all or part of a bacterial capsule." [GOC:mah, PMID:16689787]
synonym: "capsular poly-gamma-glutamate biosynthetic process" EXACT [GOC:mah]
synonym: "capsule poly-gamma-glutamate anabolism" EXACT [GOC:mah]
synonym: "capsule poly-gamma-glutamate biosynthesis" EXACT [GOC:mah]
synonym: "capsule poly-gamma-glutamate formation" EXACT [GOC:mah]
synonym: "capsule poly-gamma-glutamate synthesis" EXACT [GOC:mah]
is_a: GO:0045230 ! capsule organization
is_a: GO:0070501 ! poly-gamma-glutamate biosynthetic process

[Term]
id: GO:0070503
name: selenium-containing prosthetic group metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a prosthetic group that contains selenium, as in the selenium-dependent molybdenum hydroxylases. The selenium atom in the prosthetic group is required for enzymatic function but is labile to a variety of treatments." [GOC:dh, GOC:mah]
synonym: "selenium-containing prosthetic group metabolism" EXACT [GOC:mah]
is_a: GO:0001887 ! selenium compound metabolic process
is_a: GO:0051189 ! prosthetic group metabolic process

[Term]
id: GO:0070504
name: selenium-containing prosthetic group biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a prosthetic group that contains selenium, as in the selenium-dependent molybdenum hydroxylases. The selenium atom in the prosthetic group is required for enzymatic function but is labile to a variety of treatments." [GOC:dh, GOC:mah]
synonym: "selenium-containing prosthetic group anabolism" EXACT [GOC:mah]
synonym: "selenium-containing prosthetic group biosynthesis" EXACT [GOC:mah]
synonym: "selenium-containing prosthetic group formation" EXACT [GOC:mah]
synonym: "selenium-containing prosthetic group synthesis" EXACT [GOC:mah]
is_a: GO:0051191 ! prosthetic group biosynthetic process
is_a: GO:0070503 ! selenium-containing prosthetic group metabolic process

[Term]
id: GO:0070505
name: pollen coat
namespace: cellular_component
def: "A layer of extracellular matrix deposited onto the surface of the pollen wall upon disintegration of the tapetal layer of the anther wall in the late stages of pollen development. The composition of this material is highly heterogeneous and includes waxes, lipid droplets, small aromatic molecules, and proteins. The pollen coat is proposed to have many functions, such as holding pollen in the anther until dispersal, facilitation of pollen dispersal, protection of pollen from water loss and UV radiation, and facilitation of adhesion of pollen to the stigma." [GOC:mah, GOC:rph, PMID:12930826, PMID:15012271]
synonym: "pollenkitt" EXACT [PMID:15012271]
synonym: "tryphine" EXACT [PMID:15012271]
is_a: GO:0044420 ! extracellular matrix component

[Term]
id: GO:0070506
name: high-density lipoprotein particle receptor activity
namespace: molecular_function
def: "Combining with a high-density lipoprotein particle and delivering the high-density lipoprotein into the cell via endocytosis." [GOC:bf, GOC:BHF, GOC:rl, PMID:9211901]
synonym: "HDL receptor" EXACT [GOC:rl]
synonym: "high-density lipoprotein receptor activity" EXACT [GOC:dph]
is_a: GO:0030228 ! lipoprotein particle receptor activity
relationship: has_part GO:0008035 ! high-density lipoprotein particle binding

[Term]
id: GO:0070507
name: regulation of microtubule cytoskeleton organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
synonym: "regulation of microtubule cytoskeleton organisation" EXACT [GOC:mah]
synonym: "regulation of microtubule dynamics" EXACT [GOC:dph, GOC:tb]
is_a: GO:0032886 ! regulation of microtubule-based process
is_a: GO:0051493 ! regulation of cytoskeleton organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000226 ! microtubule cytoskeleton organization
relationship: regulates GO:0000226 ! microtubule cytoskeleton organization

[Term]
id: GO:0070508
name: cholesterol import
namespace: biological_process
def: "The directed movement of cholesterol into a cell or organelle." [GOC:BHF, GOC:rl]
synonym: "cholesterol uptake" EXACT [GOC:rl]
is_a: GO:0030301 ! cholesterol transport
is_a: GO:0035376 ! sterol import

[Term]
id: GO:0070509
name: calcium ion import
namespace: biological_process
def: "The directed movement of calcium ions into a cell or organelle." [GOC:mah]
synonym: "calcium ion uptake" EXACT [GOC:mah]
synonym: "transmembrane calcium influx" RELATED [GOC:tb]
is_a: GO:0006816 ! calcium ion transport

[Term]
id: GO:0070510
name: regulation of histone H4-K20 methylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 20 of histone H4." [GOC:mah]
is_a: GO:0031060 ! regulation of histone methylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034770 ! histone H4-K20 methylation
relationship: regulates GO:0034770 ! histone H4-K20 methylation

[Term]
id: GO:0070511
name: negative regulation of histone H4-K20 methylation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 20 of histone H4." [GOC:mah]
synonym: "down regulation of histone H4-K20 methylation" EXACT [GOC:mah]
synonym: "down-regulation of histone H4-K20 methylation" EXACT [GOC:mah]
synonym: "downregulation of histone H4-K20 methylation" EXACT [GOC:mah]
synonym: "inhibition of histone H4-K20 methylation" NARROW [GOC:mah]
is_a: GO:0031061 ! negative regulation of histone methylation
is_a: GO:0070510 ! regulation of histone H4-K20 methylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034770 ! histone H4-K20 methylation
relationship: negatively_regulates GO:0034770 ! histone H4-K20 methylation

[Term]
id: GO:0070512
name: positive regulation of histone H4-K20 methylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 20 of histone H4." [GOC:mah]
synonym: "activation of histone H4-K20 methylation" NARROW [GOC:mah]
synonym: "stimulation of histone H4-K20 methylation" NARROW [GOC:mah]
synonym: "up regulation of histone H4-K20 methylation" EXACT [GOC:mah]
synonym: "up-regulation of histone H4-K20 methylation" EXACT [GOC:mah]
synonym: "upregulation of histone H4-K20 methylation" EXACT [GOC:mah]
is_a: GO:0031062 ! positive regulation of histone methylation
is_a: GO:0070510 ! regulation of histone H4-K20 methylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034770 ! histone H4-K20 methylation
relationship: positively_regulates GO:0034770 ! histone H4-K20 methylation

[Term]
id: GO:0070513
name: death domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a death domain of a protein. The death domain (DD) is a homotypic protein interaction module composed of a bundle of six alpha-helices. DD bind each other forming oligomers. Some DD-containing proteins are involved in the regulation of apoptosis and inflammation through their activation of caspases and NF-kappaB." [GOC:BHF, GOC:rl, InterPro:IPR000488, Pfam:PF00531]
comment: For binding to the death effector domain, consider instead the term 'death effector domain binding ; GO:0035877'.
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0070514
name: SRF-myogenin-E12 complex
namespace: cellular_component
def: "A transcription factor complex that contains the serum response factor (SRF) and the basic helix-loop-helix proteins myogenin and E12, and is involved in activating transcription of muscle-specific genes." [PMID:8617811]
is_a: GO:0090575 ! RNA polymerase II transcription factor complex

[Term]
id: GO:0070515
name: alphaIIb-beta3 integrin-talin complex
namespace: cellular_component
def: "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to talin." [PMID:8663236]
synonym: "ITGA2b-ITGB3-TLN1 complex" NARROW [CORUM:2378]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070516
name: CAK-ERCC2 complex
namespace: cellular_component
def: "A protein complex formed by the association of the cyclin-dependent protein kinase activating kinase (CAK) holoenzyme complex with ERCC2." [PMID:8692841, PMID:8692842]
synonym: "cyclin-dependent protein kinase activating kinase holoenzyme-ERCC2 complex" EXACT [GOC:mah]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0070517
name: DNA replication factor C core complex
namespace: cellular_component
def: "A protein complex containing three of the five subunits of eukaryotic replication factor C, those corresponding to human p40, p38, and p37." [PMID:8692848, PMID:9228079, PMID:9582326]
subset: goslim_pir
synonym: "RFC core complex" EXACT [CORUM:278]
is_a: GO:0043234 ! protein complex
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0043599 ! nuclear DNA replication factor C complex

[Term]
id: GO:0070518
name: alpha4-beta1 integrin-CD53 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD53, a member of the tetraspan family." [PMID:8757325]
synonym: "ITGA4-ITGB1-CD53 complex" NARROW [CORUM:2420]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070519
name: alpha4-beta1 integrin-CD63 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD63, a member of the tetraspan family." [PMID:8757325]
synonym: "ITGA4-ITGB1-CD63 complex" NARROW [CORUM:2424]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070520
name: alpha4-beta1 integrin-CD81 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD81, a member of the tetraspan family." [PMID:10229664, PMID:8757325]
synonym: "ITGA4-ITGB1-CD81 complex" NARROW [CORUM:2419]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070521
name: alpha4-beta1 integrin-CD82 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD82, a member of the tetraspan family." [PMID:8757325]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070522
name: ERCC4-ERCC1 complex
namespace: cellular_component
def: "A heterodimeric nucleotide-excision repair complex that has endonuclease activity specific for bubble structures characteristic of certain DNA lesions. The subunits are known as XPF/ERCC4 and ERCC1 in mammals, and Rad1p and Rad10p in S. cerevisiae." [PMID:14734547]
comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex.
synonym: "Rad1-Rad10 complex" EXACT [GOC:mah]
synonym: "XPF-ERCC1 complex" EXACT [PMID:14734547]
is_a: GO:0000109 ! nucleotide-excision repair complex

[Term]
id: GO:0070523
name: 11-beta-hydroxysteroid dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+." [PMID:15761036]
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0070524
name: 11-beta-hydroxysteroid dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: an 11-beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+." [EC:1.1.1.146]
synonym: "11beta-hydroxysteroid:NADP+ 11-oxidoreductase" EXACT [EC:1.1.1.146]
synonym: "beta-hydroxysteroid dehydrogenase" BROAD [EC:1.1.1.146]
synonym: "corticosteroid 11-beta-dehydrogenase activity" EXACT [EC:1.1.1.146]
xref: EC:1.1.1.146
xref: MetaCyc:11-BETA-HYDROXYSTEROID-DEHYDROGENASE-RXN
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0070525
name: tRNA threonylcarbamoyladenosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tRNA threonylcarbamoyladenosine, a modified nucleoside found in some tRNA molecules." [GOC:imk, GOC:mah, PMID:19287007]
synonym: "t6A metabolic process" EXACT [PMID:19287007]
synonym: "t6A metabolism" EXACT [PMID:19287007]
synonym: "threonylcarbamoyladenosine metabolism" EXACT [GOC:MAH]
is_a: GO:0016070 ! RNA metabolic process

[Term]
id: GO:0070527
name: platelet aggregation
namespace: biological_process
def: "The adhesion of one platelet to one or more other platelets via adhesion molecules." [GOC:BHF, GOC:vk]
synonym: "blood platelet aggregation" EXACT [CL:0000233]
synonym: "thrombocyte aggregation" RELATED [CL:0000233]
is_a: GO:0034109 ! homotypic cell-cell adhesion
relationship: part_of GO:0030168 ! platelet activation

[Term]
id: GO:0070528
name: protein kinase C signaling
namespace: biological_process
def: "A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound." [GOC:BHF, GOC:mah]
synonym: "PKC signal transduction" EXACT [GOC:signaling]
synonym: "PKC signaling cascade" RELATED [GOC:mah]
synonym: "protein kinase C signal transduction" EXACT [GOC:signaling]
synonym: "protein kinase C signaling cascade" RELATED [GOC:signaling]
synonym: "protein kinase C signalling cascade" RELATED [GOC:mah]
is_a: GO:0035556 ! intracellular signal transduction

[Term]
id: GO:0070529
name: L-tryptophan aminotransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an amino group from L-tryptophan to an acceptor, usually a 2-oxo acid." [GOC:mah]
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0070530
name: K63-linked polyubiquitin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently and non-covalently with a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers." [GOC:mah, PMID:15556404, PMID:17525341]
is_a: GO:0031593 ! polyubiquitin binding

[Term]
id: GO:0070531
name: BRCA1-A complex
namespace: cellular_component
def: "A protein complex that contains the BRCA1-BARD1 heterodimer, RAP80/UIMC1, BRCC3/BRCC36, BRE/BRCC45, FAM175A/CCDC98/Abraxas and MERIT40/NBA1, and specifically recognizes and binds K63-linked polyubiquitin chains present on histone H2A and H2AX at DNA damage sites." [GOC:mah, PMID:19261749]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0070532
name: BRCA1-B complex
namespace: cellular_component
def: "A protein complex that contains the BRCA1-BARD1 heterodimer, BACH1 and TopBP1, and binds to DNA during S phase at DNA damage sites." [GOC:mah, PMID:16391231]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0070533
name: BRCA1-C complex
namespace: cellular_component
def: "A protein complex that contains the BRCA1-BARD1 heterodimer, CtIP and Mre11/Rad50/NBS1 (M/R/N) complex, and binds to DNA at DNA damage sites. BRCA1-C binding ta damaged DNA is required for DNA damage-induced Chk1 phosphorylation and the G2/M transition checkpoint." [GOC:mah, PMID:15485915, PMID:16391231]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0070534
name: protein K63-linked ubiquitination
namespace: biological_process
def: "A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair." [GOC:mah, PMID:15556404]
synonym: "protein K63-linked polyubiquitination" EXACT [GOC:mah]
is_a: GO:0000209 ! protein polyubiquitination

[Term]
id: GO:0070535
name: histone H2A K63-linked ubiquitination
namespace: biological_process
def: "A histone ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a lysine residue in histone H2A or the variant H2AX." [GOC:mah, PMID:18430235]
is_a: GO:0033522 ! histone H2A ubiquitination
is_a: GO:0070534 ! protein K63-linked ubiquitination

[Term]
id: GO:0070536
name: protein K63-linked deubiquitination
namespace: biological_process
def: "A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a protein." [GOC:mah, PMID:19202061, PMID:19214193]
xref: Reactome:REACT_25055 "Negative regulation of RIG-I/MDA5 signaling by DUBA, Homo sapiens"
xref: Reactome:REACT_25235 "CYLD mediated deubiquitination of RIG-I, Homo sapiens"
xref: Reactome:REACT_75888 "A20 deubiquitinates RIP2, Homo sapiens"
xref: Reactome:REACT_75903 "CYLD deubiquitinates NEMO, Homo sapiens"
is_a: GO:0016579 ! protein deubiquitination

[Term]
id: GO:0070537
name: histone H2A K63-linked deubiquitination
namespace: biological_process
def: "A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a lysine residue in histone H2A or the variant H2AX." [GOC:mah, PMID:19202061, PMID:19214193]
is_a: GO:0016578 ! histone deubiquitination
is_a: GO:0070536 ! protein K63-linked deubiquitination

[Term]
id: GO:0070538
name: oleic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with oleic acid, the 18-carbon monounsaturated fatty acid (9Z)-octadec-9-enoic acid." [CHEBI:16196, GOC:lp, GOC:mah]
is_a: GO:0036041 ! long-chain fatty acid binding

[Term]
id: GO:0070539
name: linoleic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with linoleic acid, the 18-carbon unsaturated fatty acid (9Z,12Z)-octadeca-9,12-dienoic acid." [CHEBI:17351, GOC:lp, GOC:mah]
is_a: GO:0036041 ! long-chain fatty acid binding

[Term]
id: GO:0070540
name: stearic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with stearic acid, the 18-carbon saturated fatty acid octadecanoic acid." [CHEBI:28842, GOC:lp, GOC:mah]
is_a: GO:0036041 ! long-chain fatty acid binding

[Term]
id: GO:0070541
name: response to platinum ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platinum stimulus." [GOC:sl]
synonym: "response to platinum" EXACT [GOC:mah]
is_a: GO:0010038 ! response to metal ion

[Term]
id: GO:0070542
name: response to fatty acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus." [CHEBI:35366, GOC:lp]
is_a: GO:0001101 ! response to acid chemical
is_a: GO:0033993 ! response to lipid
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0070543
name: response to linoleic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a linoleic acid stimulus." [CHEBI:17351, GOC:lp]
synonym: "response to linoleate" EXACT [GOC:mah]
is_a: GO:0070542 ! response to fatty acid

[Term]
id: GO:0070544
name: histone H3-K36 demethylation
namespace: biological_process
def: "The modification of histone H3 by the removal of a methyl group from lysine at position 36 of the histone." [GOC:sart, PMID:19061644]
synonym: "H3K36 demethylation" RELATED []
is_a: GO:0070076 ! histone lysine demethylation

[Term]
id: GO:0070545
name: PeBoW complex
namespace: cellular_component
def: "A protein complex that is involved in coordinating ribosome biogenesis with cell cycle progression. In human, it is composed of Pes1, Bop1, and WDR12; in Saccharomyces the proteins are known as Nop7p, Erb1 and Ytm1 respectively." [GOC:ab, GOC:mah, PMID:16043514, PMID:17353269]
is_a: GO:0043234 ! protein complex
is_a: GO:0044452 ! nucleolar part
relationship: part_of GO:0030686 ! 90S preribosome

[Term]
id: GO:0070546
name: L-phenylalanine aminotransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an amino group from L-phenylalanine to an acceptor, usually a 2-oxo acid." [GOC:mah]
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0070547
name: L-tyrosine aminotransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an amino group from L-tyrosine to an acceptor, usually a 2-oxo acid." [GOC:mah]
subset: gosubset_prok
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0070548
name: L-glutamine aminotransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an amino group from L-glutamine to an acceptor, usually a 2-oxo acid." [GOC:mah]
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0070549
name: negative regulation of translation involved in RNA interference
namespace: biological_process
def: "A process of negative regulation of translation that is mediated by the association of small interfering RNAs (siRNAs) with a cognate target mRNA." [GOC:mah, PMID:18771919]
synonym: "down regulation of translation involved in RNA interference" EXACT [GOC:mah]
synonym: "down-regulation of translation involved in RNA interference" EXACT [GOC:mah]
synonym: "downregulation of translation involved in RNA interference" EXACT [GOC:mah]
synonym: "inhibition of translation involved in RNA interference" NARROW [GOC:mah]
synonym: "RNA interference, negative regulation of translation" EXACT [GOC:mah]
is_a: GO:0040033 ! negative regulation of translation, ncRNA-mediated
intersection_of: GO:0017148 ! negative regulation of translation
intersection_of: part_of GO:0016246 ! RNA interference
relationship: part_of GO:0016246 ! RNA interference

[Term]
id: GO:0070550
name: rDNA condensation
namespace: biological_process
def: "The process in which the chromatin structure of the rDNA repeats is compacted. In S. cerevisiae, condensation and resolution of the rDNA occurs during anaphase." [GOC:dgf, PMID:10811823, PMID:15137940]
synonym: "rDNA packaging" EXACT []
is_a: GO:0006323 ! DNA packaging
relationship: part_of GO:0030261 ! chromosome condensation

[Term]
id: GO:0070551
name: endoribonuclease activity, cleaving siRNA-paired mRNA
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of the mRNA in a double-stranded RNA molecule formed by the base pairing of an mRNA with an siRNA, yielding 5'-phosphomonoesters." [GOC:mah, PMID:15105377]
synonym: "argonaute endoribonuclease activity" RELATED [GOC:mah]
is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0070552
name: BRISC complex
namespace: cellular_component
def: "A protein complex that contains the FAM175B/ABRO1, BRCC3/BRCC36, BRE/BRCC45 and MERIT40/NBA1 proteins, and specifically cleaves K63-linked polyubiquitin chains." [GOC:mah, PMID:19214193]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0070553
name: nicotinic acid receptor activity
namespace: molecular_function
def: "Combining with nicotinic acid to initiate a change in cell activity." [CHEBI:15940, GOC:mah, PMID:12522134]
synonym: "niacin receptor activity" EXACT [CHEBI:15940, GOC:mah]
is_a: GO:0004930 ! G-protein coupled receptor activity

[Term]
id: GO:0070554
name: synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex
namespace: cellular_component
def: "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 3, and a complexin (or orthologs thereof)." [PMID:8824312]
synonym: "SNARE complex (Stx3, Snap25, Vamp2, Cplx1)" NARROW [CORUM:842]
synonym: "Stx3-Snap25-Vamp2-Cplx1 complex" NARROW [CORUM:842]
is_a: GO:0031201 ! SNARE complex

[Term]
id: GO:0070555
name: response to interleukin-1
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus." [GOC:BHF, GOC:mah]
synonym: "response to IL-1" EXACT [GOC:mah]
is_a: GO:0034097 ! response to cytokine

[Term]
id: GO:0070556
name: TAF4B-containing transcription factor TFIID complex
namespace: cellular_component
def: "A transcription factor TFIID complex that contains the TBP-associated factor TAF4B (also known as TAFII105 in human), a cell-type-specific variant of TAF4." [GOC:mah, PMID:8858156]
synonym: "TFIID complex, B-cell specific" RELATED [CORUM:485]
is_a: GO:0005669 ! transcription factor TFIID complex

[Term]
id: GO:0070557
name: PCNA-p21 complex
namespace: cellular_component
def: "A protein complex that contains the cyclin-dependent protein kinase inhibitor p21WAF1/CIP1 bound to PCNA; formation of the complex inhibits DNA replication." [GOC:mah, PMID:7911228, PMID:7915843]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0070558
name: alphaM-beta2 integrin-CD63 complex
namespace: cellular_component
def: "A protein complex that consists of an alphaM-beta2 integrin complex bound to membrane protein CD63, a member of the tetraspan family." [PMID:8871662]
synonym: "ITGAM-ITGB2-CD63 complex" NARROW [CORUM:2153]
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0070559
name: lysosomal multienzyme complex
namespace: cellular_component
def: "A protein complex found in the lysosome that contains beta-galactosidase, cathepsin A, alpha-neuraminidase and N-acetylgalactosamine-6-sulfate sulfatase, and is involved in glycosaminoglycan catabolism." [GOC:mah, PMID:8910459]
synonym: "GALNS-lysosomal hydrolase 1.27 MDa complex" NARROW [CORUM:1379]
is_a: GO:0043234 ! protein complex
is_a: GO:0044437 ! vacuolar part
relationship: part_of GO:0005764 ! lysosome

[Term]
id: GO:0070560
name: protein secretion by platelet
namespace: biological_process
def: "The regulated release of proteins by a platelet or group of platelets." [GOC:BHF, GOC:mah]
is_a: GO:0009306 ! protein secretion
relationship: part_of GO:0002576 ! platelet degranulation
created_by: midori
creation_date: 2009-04-09T02:38:05Z

[Term]
id: GO:0070561
name: vitamin D receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a vitamin D receptor binding to one of its physiological ligands." [GOC:BHF, GOC:mah, PMID:12637589]
synonym: "calcitriol signaling pathway" NARROW [GOC:bf]
synonym: "VDR signaling pathway" EXACT [PMID:12637589]
synonym: "vitamin D receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0030522 ! intracellular receptor signaling pathway
relationship: part_of GO:0071305 ! cellular response to vitamin D
created_by: midori
creation_date: 2009-04-14T01:43:59Z

[Term]
id: GO:0070562
name: regulation of vitamin D receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vitamin D receptor signaling pathway activity." [GOC:BHF, GOC:mah]
synonym: "regulation of VDR signaling pathway" EXACT [PMID:12637589]
synonym: "regulation of vitamin D receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0032107 ! regulation of response to nutrient levels
is_a: GO:1901419 ! regulation of response to alcohol
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070561 ! vitamin D receptor signaling pathway
relationship: regulates GO:0070561 ! vitamin D receptor signaling pathway
created_by: midori
creation_date: 2009-04-14T01:46:03Z

[Term]
id: GO:0070563
name: negative regulation of vitamin D receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the vitamin D receptor signaling pathway activity." [GOC:BHF, GOC:mah]
synonym: "down regulation of vitamin D receptor signaling pathway" EXACT [GOC:mah]
synonym: "down-regulation of vitamin D receptor signaling pathway" EXACT [GOC:mah]
synonym: "downregulation of vitamin D receptor signaling pathway" EXACT [GOC:mah]
synonym: "inhibition of vitamin D receptor signaling pathway" NARROW [GOC:mah]
synonym: "negative regulation of VDR signaling pathway" EXACT [GOC:mah]
synonym: "negative regulation of VDR signalling pathway" EXACT [GOC:mah]
synonym: "negative regulation vitamin D receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0032108 ! negative regulation of response to nutrient levels
is_a: GO:0070562 ! regulation of vitamin D receptor signaling pathway
is_a: GO:1901420 ! negative regulation of response to alcohol
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070561 ! vitamin D receptor signaling pathway
relationship: negatively_regulates GO:0070561 ! vitamin D receptor signaling pathway
created_by: midori
creation_date: 2009-04-14T01:59:21Z

[Term]
id: GO:0070564
name: positive regulation of vitamin D receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vitamin D receptor signaling pathway activity." [GOC:BHF, GOC:mah]
synonym: "activation of vitamin D receptor signaling pathway" NARROW [GOC:mah]
synonym: "positive regulation of VDR signaling pathway" EXACT [GOC:mah]
synonym: "positive regulation of vitamin D receptor signalling pathway" EXACT [GOC:mah]
synonym: "stimulation of vitamin D receptor signaling pathway" NARROW [GOC:mah]
synonym: "up regulation of vitamin D receptor signaling pathway" EXACT [GOC:mah]
synonym: "up-regulation of vitamin D receptor signaling pathway" EXACT [GOC:mah]
synonym: "upregulation of vitamin D receptor signaling pathway" EXACT [GOC:mah]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0032109 ! positive regulation of response to nutrient levels
is_a: GO:0070562 ! regulation of vitamin D receptor signaling pathway
is_a: GO:1901421 ! positive regulation of response to alcohol
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070561 ! vitamin D receptor signaling pathway
relationship: positively_regulates GO:0070561 ! vitamin D receptor signaling pathway
created_by: midori
creation_date: 2009-04-14T02:02:54Z

[Term]
id: GO:0070565
name: telomere-telomerase complex
namespace: cellular_component
def: "A complex of DNA and protein located at the end of a linear chromosome that enables replication of the telomeric repeat sequences at the end of a linear chromosome." [GOC:pde, PMID:19179534]
comment: Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific protein complex and not a region of the chromosome.
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0032993 ! protein-DNA complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000781 ! chromosome, telomeric region
created_by: midori
creation_date: 2009-04-14T03:07:50Z

[Term]
id: GO:0070566
name: adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an adenylyl group to an acceptor." [GOC:mah]
subset: gosubset_prok
is_a: GO:0016779 ! nucleotidyltransferase activity
created_by: midori
creation_date: 2009-04-15T11:04:22Z

[Term]
id: GO:0070567
name: cytidylyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a cytidylyl group to an acceptor." [GOC:mah]
subset: gosubset_prok
is_a: GO:0016779 ! nucleotidyltransferase activity
created_by: midori
creation_date: 2009-04-15T11:05:22Z

[Term]
id: GO:0070568
name: guanylyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a guanylyl group to an acceptor." [GOC:mah]
subset: gosubset_prok
is_a: GO:0016779 ! nucleotidyltransferase activity
created_by: midori
creation_date: 2009-04-15T11:05:47Z

[Term]
id: GO:0070569
name: uridylyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an uridylyl group to an acceptor." [GOC:mah]
subset: gosubset_prok
is_a: GO:0016779 ! nucleotidyltransferase activity
created_by: midori
creation_date: 2009-04-15T11:06:07Z

[Term]
id: GO:0070570
name: regulation of neuron projection regeneration
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of neuron projection regeneration, the regrowth of neuronal processes such as axons or dendrites following their loss or damage." [GOC:mah]
is_a: GO:0010975 ! regulation of neuron projection development
is_a: GO:0080135 ! regulation of cellular response to stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031102 ! neuron projection regeneration
relationship: regulates GO:0031102 ! neuron projection regeneration
created_by: midori
creation_date: 2009-04-15T01:23:48Z

[Term]
id: GO:0070571
name: negative regulation of neuron projection regeneration
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neuron projection regeneration, the regrowth of neuronal processes such as axons or dendrites following their loss or damage." [GOC:mah]
synonym: "growth cone collapse" RELATED [GOC:pr]
is_a: GO:0010977 ! negative regulation of neuron projection development
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:0070570 ! regulation of neuron projection regeneration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0031102 ! neuron projection regeneration
relationship: negatively_regulates GO:0031102 ! neuron projection regeneration
created_by: midori
creation_date: 2009-04-15T01:43:19Z

[Term]
id: GO:0070572
name: positive regulation of neuron projection regeneration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neuron projection regeneration, the regrowth of neuronal processes such as axons or dendrites following their loss or damage." [GOC:mah]
is_a: GO:0010976 ! positive regulation of neuron projection development
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:0070570 ! regulation of neuron projection regeneration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0031102 ! neuron projection regeneration
relationship: positively_regulates GO:0031102 ! neuron projection regeneration
created_by: midori
creation_date: 2009-04-15T01:45:27Z

[Term]
id: GO:0070573
name: metallodipeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a dipeptide by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
synonym: "metallo-exo-dipeptidase activity" EXACT [GOC:rb]
synonym: "metalloexodipeptidase activity" EXACT [GOC:mah]
is_a: GO:0008235 ! metalloexopeptidase activity
is_a: GO:0016805 ! dipeptidase activity
created_by: midori
creation_date: 2009-04-15T03:11:29Z

[Term]
id: GO:0070574
name: cadmium ion transmembrane transport
namespace: biological_process
def: "A process in which a cadmium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
subset: gosubset_prok
synonym: "cadmium ion membrane transport" EXACT []
synonym: "transmembrane cadmium transport" EXACT [GOC:mah]
is_a: GO:0015691 ! cadmium ion transport
is_a: GO:0098662 ! inorganic cation transmembrane transport
created_by: midori
creation_date: 2009-04-20T03:31:47Z

[Term]
id: GO:0070575
name: peptide mating pheromone maturation involved in pheromone-induced unidirectional conjugation
namespace: biological_process
def: "The formation of a mature peptide mating pheromone by proteolysis and/or modification of a peptide precursor, occurring in the context of pheromone-induced unidirectional conjugation." [GOC:mah]
synonym: "peptide mating pheromone formation involved in pheromone-induced unidirectional conjugation" EXACT [GOC:mah]
synonym: "peptide mating pheromone processing involved in pheromone-induced unidirectional conjugation" EXACT [GOC:mah]
is_a: GO:0007323 ! peptide pheromone maturation
relationship: part_of GO:0000762 ! pheromone-induced unidirectional conjugation
created_by: midori
creation_date: 2009-04-20T04:32:07Z

[Term]
id: GO:0070576
name: vitamin D 24-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the hydroxylation of C-24 of any form of vitamin D." [GOC:BHF, GOC:mah, PMID:15546903]
synonym: "calciferol 24-hydroxylase activity" NARROW [GOC:rl]
synonym: "cholecalciferol 24-hydroxylase activity" NARROW [GOC:rl]
synonym: "ergocalciferol 24-hydroxylase activity" NARROW [GOC:rl]
synonym: "vitamin D2 24-hydroxylase activity" NARROW [GOC:rl]
synonym: "vitamin D3 24-hydroxylase activity" NARROW [GOC:rl]
is_a: GO:0016491 ! oxidoreductase activity
created_by: midori
creation_date: 2009-04-21T02:20:52Z

[Term]
id: GO:0070577
name: lysine-acetylated histone binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a histone in which a lysine residue has been modified by acetylation." [GOC:BHF, GOC:mah, GOC:rl, PMID:17582821]
synonym: "acetylated histone residue binding" BROAD [GOC:rl]
is_a: GO:0042393 ! histone binding
created_by: midori
creation_date: 2009-04-21T03:03:35Z

[Term]
id: GO:0070578
name: RISC-loading complex
namespace: cellular_component
def: "A trimeric ribonucleoprotein complex that and is required for the formation of a mature RNA induced silencing complex (RISC). In humans the complex is composed of the endonuclease Dicer (DICER1) and TRBP (TARBP2) in association with the Argonaute protein Ago2 (EIF2C2/AGO2). Within the complex, Dicer and TRBP are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto Ago2. Ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from Dicer and TRBP.  This complex has endoribonuclease activity." [GOC:ab, GOC:BHF, GOC:nc, GOC:rph, PMID:18178619, PMID:19820710]
synonym: "microRNA loading complex" EXACT [GOC:ab]
synonym: "miRLC" EXACT [GOC:ab]
synonym: "RLC" RELATED [GOC:ab, GOC:mah]
is_a: GO:0030529 ! intracellular ribonucleoprotein complex
is_a: GO:1902555 ! endoribonuclease complex
created_by: midori
creation_date: 2009-04-22T01:40:19Z

[Term]
id: GO:0070579
name: methylcytosine dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: methylcytosine + 2-oxoglutarate + O2 = 5-hydroxymethylcytosine + succinate + CO2." [PMID:19372391]
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
created_by: midori
creation_date: 2009-04-22T02:29:41Z

[Term]
id: GO:0070580
name: base J metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving base J (beta-D-glucosyl-hydroxymethyluracil), a hypermodified thymidine residue found in the genome of kinetoplastid parasites. This modified base is localized primarily to repetitive DNA, namely the telomeres, and is implicated in the regulation of antigenic variation. The base is synthesized in a two-step pathway. Initially, a thymidine residue in DNA is hydroxylated by a thymidine hydroxylase (TH) to form the intermediate hydroxymethyluracil, which is then glucosylated to form base J." [PMID:19114062]
synonym: "base J metabolism" EXACT [GOC:mah]
synonym: "beta-D-glucosyl-HOMedU metabolic process" EXACT [GOC:mah]
synonym: "beta-D-glucosyl-hydroxymethyluracil metabolism" EXACT [PMID:19114062]
is_a: GO:0006304 ! DNA modification
created_by: midori
creation_date: 2009-04-22T02:37:23Z

[Term]
id: GO:0070581
name: rolling circle DNA replication
namespace: biological_process
def: "A DNA-dependent DNA replication process in which a single-stranded DNA molecule is synthesized from a circular duplex template. Replication typically does not cease when one circumference has been replicated, but continues around the circumference several more times, producing a long single strand comprising multimers of the replicon." [GOC:cb, GOC:mah, ISBN:0198506732]
synonym: "rolling circle replication" EXACT [GOC:cb]
is_a: GO:0006261 ! DNA-dependent DNA replication
created_by: midori
creation_date: 2009-04-22T02:53:52Z

[Term]
id: GO:0070582
name: theta DNA replication
namespace: biological_process
def: "A DNA-dependent DNA replication process in which a double-stranded DNA molecule is synthesized from a circular duplex template." [GOC:cb, GOC:mah, ISBN:0198506732]
synonym: "theta replication" EXACT [GOC:cb]
is_a: GO:0006261 ! DNA-dependent DNA replication
created_by: midori
creation_date: 2009-04-22T02:54:50Z

[Term]
id: GO:0070583
name: spore membrane bending pathway
namespace: biological_process
def: "The process in which a bending force is generated in the prospore membrane to form the characteristic curved shape of the prospore." [GOC:dgf, PMID:18756268]
synonym: "ascospore-type prospore membrane bending" EXACT [GOC:mah]
synonym: "forespore membrane bending" EXACT [GOC:mah]
synonym: "FSM bending" EXACT [GOC:mah]
is_a: GO:0044802 ! single-organism membrane organization
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0032120 ! ascospore-type prospore membrane assembly
created_by: midori
creation_date: 2009-04-24T10:48:09Z

[Term]
id: GO:0070584
name: mitochondrion morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a mitochondrion are generated and organized." [GOC:mah]
comment: This term was added by GO_REF:0000021. Note that this term is intended for annotation of gene products involved in mitochondrial shape changes associated with development; an example is the morphogenesis of the Nebenkern during spermatogenesis.
is_a: GO:0007005 ! mitochondrion organization
is_a: GO:0032990 ! cell part morphogenesis
is_a: GO:1902589 ! single-organism organelle organization
created_by: midori
creation_date: 2009-04-24T10:54:19Z

[Term]
id: GO:0070585
name: protein localization to mitochondrion
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within the mitochondrion." [GOC:ecd]
synonym: "protein localisation in mitochondrion" EXACT [GOC:mah]
synonym: "protein localization in mitochondrion" EXACT [GOC:curators]
is_a: GO:0033365 ! protein localization to organelle
created_by: midori
creation_date: 2009-04-24T02:31:18Z

[Term]
id: GO:0070586
name: cell-cell adhesion involved in gastrulation
namespace: biological_process
def: "The attachment of one cell to another cell affecting gastrulation." [GOC:dsf, PMID:19091770]
comment: This term was added by GO_REF:0000021.
is_a: GO:0016337 ! single organismal cell-cell adhesion
is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules
intersection_of: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules
intersection_of: part_of GO:0007369 ! gastrulation
relationship: part_of GO:0007369 ! gastrulation
created_by: midori
creation_date: 2009-04-24T02:48:23Z

[Term]
id: GO:0070587
name: regulation of cell-cell adhesion involved in gastrulation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of attachment of a cell to another cell affecting gastrulation." [GOC:dsf, PMID:19091770]
is_a: GO:0010470 ! regulation of gastrulation
is_a: GO:0022407 ! regulation of cell-cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070586 ! cell-cell adhesion involved in gastrulation
relationship: regulates GO:0070586 ! cell-cell adhesion involved in gastrulation
created_by: midori
creation_date: 2009-04-24T02:51:07Z

[Term]
id: GO:0070588
name: calcium ion transmembrane transport
namespace: biological_process
def: "A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
subset: gosubset_prok
synonym: "calcium ion membrane transport" EXACT []
synonym: "transmembrane calcium transport" EXACT [GOC:mah]
is_a: GO:0006816 ! calcium ion transport
is_a: GO:0098662 ! inorganic cation transmembrane transport
created_by: midori
creation_date: 2009-04-28T10:44:09Z

[Term]
id: GO:0070589
name: cellular component macromolecule biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a macromolecule that is destined to form part of a specific cellular component." [GOC:mah]
synonym: "cellular component macromolecule biosynthesis" EXACT [GOC:mah]
is_a: GO:0034645 ! cellular macromolecule biosynthetic process
relationship: part_of GO:0044085 ! cellular component biogenesis
created_by: midori
creation_date: 2009-04-28T11:01:25Z

[Term]
id: GO:0070590
name: spore wall biogenesis
namespace: biological_process
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a spore wall. A spore wall is the specialized cell wall lying outside the cell membrane of a spore." [GOC:mah]
is_a: GO:0042546 ! cell wall biogenesis
relationship: part_of GO:0030435 ! sporulation resulting in formation of a cellular spore
created_by: midori
creation_date: 2009-04-28T01:06:10Z

[Term]
id: GO:0070591
name: ascospore wall biogenesis
namespace: biological_process
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of an ascospore wall." [GOC:mah]
is_a: GO:0009272 ! fungal-type cell wall biogenesis
is_a: GO:0070590 ! spore wall biogenesis
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0030437 ! ascospore formation
created_by: midori
creation_date: 2009-04-28T01:12:11Z

[Term]
id: GO:0070592
name: cell wall polysaccharide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a polysaccharide destined to form part of a cell wall." [GOC:mah]
subset: gosubset_prok
synonym: "cell wall polysaccharide anabolism" EXACT [GOC:mah]
synonym: "cell wall polysaccharide biosynthesis" EXACT [GOC:mah]
synonym: "cell wall polysaccharide synthesis" EXACT [GOC:mah]
is_a: GO:0010383 ! cell wall polysaccharide metabolic process
is_a: GO:0033692 ! cellular polysaccharide biosynthetic process
is_a: GO:0044038 ! cell wall macromolecule biosynthetic process
created_by: midori
creation_date: 2009-04-28T01:25:54Z

[Term]
id: GO:0070593
name: dendrite self-avoidance
namespace: biological_process
def: "The process in which dendrites recognize and avoid contact with sister dendrites from the same cell." [GOC:sart, PMID:17482551]
synonym: "dendrite repulsion" EXACT [GOC:sart]
is_a: GO:0008038 ! neuron recognition
created_by: midori
creation_date: 2009-04-28T03:29:14Z

[Term]
id: GO:0070594
name: juvenile hormone response element binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the juvenile hormone response element (JHRE), a conserved sequence found in the promoters of genes whose expression is regulated in response to juvenile hormone." [GOC:sart, PMID:17956872]
comment: Note that as agreed during the transcription overhaul, terms specifying binding to specific transcription regulatory motifs are no longer being created. The level of specificity GO has decided to go to is the "core promoter", "core promoter proximal region" and "enhancer". To capture more detail, please consider using column 16.
synonym: "JHRE binding" EXACT [GOC:mah]
is_a: GO:0044212 ! transcription regulatory region DNA binding
created_by: midori
creation_date: 2009-04-28T03:31:27Z

[Term]
id: GO:0070595
name: (1->3)-alpha-glucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds." [GOC:mah]
synonym: "1,3-alpha-glucan metabolic process" EXACT [GOC:mah]
synonym: "1,3-alpha-glucan metabolism" EXACT [GOC:mah]
synonym: "alpha-1,3 glucan metabolic process" EXACT [GOC:mah]
synonym: "alpha-1,3 glucan metabolism" EXACT [GOC:mah]
is_a: GO:0030978 ! alpha-glucan metabolic process
created_by: midori
creation_date: 2009-04-28T03:35:03Z

[Term]
id: GO:0070596
name: (1->3)-alpha-glucan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds." [GOC:mah]
synonym: "1,3-alpha-glucan anabolism" EXACT [GOC:mah]
synonym: "1,3-alpha-glucan biosynthesis" EXACT [GOC:mah]
synonym: "1,3-alpha-glucan biosynthetic process" EXACT [GOC:mah]
synonym: "1,3-alpha-glucan formation" EXACT [GOC:mah]
synonym: "1,3-alpha-glucan synthesis" EXACT [GOC:mah]
synonym: "alpha-1,3 glucan anabolism" EXACT [GOC:mah]
synonym: "alpha-1,3 glucan biosynthesis" EXACT [GOC:mah]
synonym: "alpha-1,3 glucan biosynthetic process" EXACT [GOC:mah]
synonym: "alpha-1,3 glucan formation" EXACT [GOC:mah]
synonym: "alpha-1,3 glucan synthesis" EXACT [GOC:mah]
is_a: GO:0030979 ! alpha-glucan biosynthetic process
is_a: GO:0070595 ! (1->3)-alpha-glucan metabolic process
created_by: midori
creation_date: 2009-04-28T03:39:24Z

[Term]
id: GO:0070597
name: cell wall (1->3)-alpha-glucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds, found in the walls of cells." [GOC:mah]
synonym: "cell wall 1,3-alpha-glucan metabolic process" EXACT [GOC:mah]
synonym: "cell wall 1,3-alpha-glucan metabolism" EXACT [GOC:mah]
synonym: "cell wall alpha-1,3 glucan metabolic process" EXACT [GOC:mah]
synonym: "cell wall alpha-1,3 glucan metabolism" EXACT [GOC:mah]
is_a: GO:0070595 ! (1->3)-alpha-glucan metabolic process
created_by: midori
creation_date: 2009-04-28T04:03:00Z

[Term]
id: GO:0070598
name: cell wall (1->3)-alpha-glucan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-glucosidic bonds, found in the walls of cells." [GOC:mah]
synonym: "cell wall 1,3-alpha-glucan anabolism" EXACT [GOC:mah]
synonym: "cell wall 1,3-alpha-glucan biosynthesis" EXACT [GOC:mah]
synonym: "cell wall 1,3-alpha-glucan biosynthetic process" EXACT [GOC:mah]
synonym: "cell wall 1,3-alpha-glucan formation" EXACT [GOC:mah]
synonym: "cell wall 1,3-alpha-glucan synthesis" EXACT [GOC:mah]
synonym: "cell wall alpha-1,3-glucan anabolism" EXACT [GOC:mah]
synonym: "cell wall alpha-1,3-glucan biosynthesis" EXACT [GOC:mah]
synonym: "cell wall alpha-1,3-glucan biosynthetic process" EXACT [GOC:mah]
synonym: "cell wall alpha-1,3-glucan formation" EXACT [GOC:mah]
synonym: "cell wall alpha-1,3-glucan synthesis" EXACT [GOC:mah]
is_a: GO:0070592 ! cell wall polysaccharide biosynthetic process
is_a: GO:0070596 ! (1->3)-alpha-glucan biosynthetic process
is_a: GO:0070597 ! cell wall (1->3)-alpha-glucan metabolic process
created_by: midori
creation_date: 2009-04-28T04:04:59Z

[Term]
id: GO:0070599
name: fungal-type cell wall (1->3)-alpha-glucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds, found in the walls of ascospores." [GOC:mah]
synonym: "ascospore wall 1,3-alpha-glucan metabolic process" EXACT [GOC:mah]
synonym: "ascospore wall 1,3-alpha-glucan metabolism" EXACT [GOC:mah]
synonym: "ascospore wall alpha-1,3 glucan metabolic process" EXACT [GOC:mah]
synonym: "ascospore wall alpha-1,3 glucan metabolism" EXACT [GOC:mah]
is_a: GO:0070597 ! cell wall (1->3)-alpha-glucan metabolic process
created_by: midori
creation_date: 2009-04-28T04:07:23Z

[Term]
id: GO:0070600
name: fungal-type cell wall (1->3)-alpha-glucan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds, found in fungal-type cell walls, including those of ascospores." [GOC:mah]
synonym: "fungal-type cell wall 1,3-alpha-glucan anabolism" EXACT [GOC:mah]
synonym: "fungal-type cell wall 1,3-alpha-glucan biosynthesis" EXACT [GOC:mah]
synonym: "fungal-type cell wall 1,3-alpha-glucan biosynthetic process" EXACT [GOC:mah]
synonym: "fungal-type cell wall 1,3-alpha-glucan formation" EXACT [GOC:mah]
synonym: "fungal-type cell wall 1,3-alpha-glucan synthesis" EXACT [GOC:mah]
synonym: "fungal-type cell wall alpha-1,3-glucan anabolism" EXACT [GOC:mah]
synonym: "fungal-type cell wall alpha-1,3-glucan biosynthesis" EXACT [GOC:mah]
synonym: "fungal-type cell wall alpha-1,3-glucan biosynthetic process" EXACT [GOC:mah]
synonym: "fungal-type cell wall alpha-1,3-glucan formation" EXACT [GOC:mah]
synonym: "fungal-type cell wall alpha-1,3-glucan synthesis" EXACT [GOC:mah]
is_a: GO:0070598 ! cell wall (1->3)-alpha-glucan biosynthetic process
is_a: GO:0070599 ! fungal-type cell wall (1->3)-alpha-glucan metabolic process
created_by: midori
creation_date: 2009-04-28T04:09:48Z

[Term]
id: GO:0070601
name: centromeric sister chromatid cohesion
namespace: biological_process
def: "The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the length of the centromeric region of the chromosome." [GOC:mah]
synonym: "sister chromatid cohesion at centromere" EXACT [GOC:mah]
is_a: GO:0007062 ! sister chromatid cohesion
created_by: midori
creation_date: 2009-04-28T04:31:00Z

[Term]
id: GO:0070602
name: regulation of centromeric sister chromatid cohesion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sister chromatid cohesion in the centromeric region of a chromosome." [GOC:mah]
synonym: "regulation of sister chromatid cohesion at centromere" EXACT [GOC:mah]
is_a: GO:0007063 ! regulation of sister chromatid cohesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070601 ! centromeric sister chromatid cohesion
relationship: regulates GO:0070601 ! centromeric sister chromatid cohesion
created_by: midori
creation_date: 2009-04-28T04:32:53Z

[Term]
id: GO:0070603
name: SWI/SNF superfamily-type complex
namespace: cellular_component
def: "A protein complex that contains an ortholog of the Saccharomyces ATPase Swi2/Snf2 as one of the core components and mediates assembly of nucleosomes, changes to the spacing or structure of nucleosomes, or some combination of those activities in a manner that requires ATP." [GOC:krc, GOC:mah, PMID:16155938]
synonym: "SWI-SNF global transcription activator complex" RELATED [CORUM:224]
synonym: "SWI-SNF-type complex" EXACT [GOC:mah]
synonym: "SWI/SNF-type complex" RELATED [GOC:krc]
synonym: "SWI2/SNF2 superfamily ATP-dependent chromatin remodeling complex" RELATED [GOC:krc]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part
created_by: midori
creation_date: 2009-04-29T12:55:46Z

[Term]
id: GO:0070604
name: PBAF complex
namespace: cellular_component
def: "A SWI/SNF-type complex that contains the ATPase product of the mammalian BAF180 gene." [GOC:mah, PMID:16155938, PMID:8895581]
synonym: "Polybromo- and BAF containing complex" EXACT [CORUM:565]
synonym: "SWI/SNF complex B" EXACT [CORUM:565]
is_a: GO:0090544 ! BAF-type complex
created_by: midori
creation_date: 2009-04-29T01:07:26Z

[Term]
id: GO:0070605
name: regulation of (1->3)-alpha-glucan metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds." [GOC:mah]
synonym: "regulation of 1,3-alpha-glucan metabolic process" EXACT [GOC:mah]
synonym: "regulation of 1,3-alpha-glucan metabolism" EXACT [GOC:mah]
synonym: "regulation of alpha-1,3 glucan metabolic process" EXACT [GOC:mah]
synonym: "regulation of alpha-1,3 glucan metabolism" EXACT [GOC:mah]
is_a: GO:0032948 ! regulation of alpha-glucan metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070595 ! (1->3)-alpha-glucan metabolic process
relationship: regulates GO:0070595 ! (1->3)-alpha-glucan metabolic process
created_by: midori
creation_date: 2009-04-29T01:20:12Z

[Term]
id: GO:0070606
name: regulation of (1->3)-alpha-glucan biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds." [GOC:mah]
synonym: "regulation of 1,3-alpha-glucan anabolism" EXACT [GOC:mah]
synonym: "regulation of 1,3-alpha-glucan biosynthesis" EXACT [GOC:mah]
synonym: "regulation of 1,3-alpha-glucan biosynthetic process" EXACT [GOC:mah]
synonym: "regulation of 1,3-alpha-glucan formation" EXACT [GOC:mah]
synonym: "regulation of 1,3-alpha-glucan synthesis" EXACT [GOC:mah]
synonym: "regulation of alpha-1,3 glucan anabolism" EXACT [GOC:mah]
synonym: "regulation of alpha-1,3 glucan biosynthesis" EXACT [GOC:mah]
synonym: "regulation of alpha-1,3 glucan biosynthetic process" EXACT [GOC:mah]
synonym: "regulation of alpha-1,3 glucan formation" EXACT [GOC:mah]
synonym: "regulation of alpha-1,3 glucan synthesis" EXACT [GOC:mah]
is_a: GO:0032949 ! regulation of alpha-glucan biosynthetic process
is_a: GO:0070605 ! regulation of (1->3)-alpha-glucan metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070596 ! (1->3)-alpha-glucan biosynthetic process
relationship: regulates GO:0070596 ! (1->3)-alpha-glucan biosynthetic process
created_by: midori
creation_date: 2009-04-29T01:22:45Z

[Term]
id: GO:0070607
name: regulation of cell wall (1->3)-alpha-glucan metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds, found in the walls of cells." [GOC:mah]
synonym: "regulation of cell wall 1,3-alpha-glucan metabolic process" EXACT [GOC:mah]
synonym: "regulation of cell wall 1,3-alpha-glucan metabolism" EXACT [GOC:mah]
synonym: "regulation of cell wall alpha-1,3 glucan metabolic process" EXACT [GOC:mah]
synonym: "regulation of cell wall alpha-1,3 glucan metabolism" EXACT [GOC:mah]
is_a: GO:0070605 ! regulation of (1->3)-alpha-glucan metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070597 ! cell wall (1->3)-alpha-glucan metabolic process
relationship: regulates GO:0070597 ! cell wall (1->3)-alpha-glucan metabolic process
created_by: midori
creation_date: 2009-04-29T01:24:57Z

[Term]
id: GO:0070608
name: regulation of cell wall (1->3)-alpha-glucan biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds, found in the walls of cells." [GOC:mah]
synonym: "regulation of cell wall 1,3-alpha-glucan anabolism" EXACT [GOC:mah]
synonym: "regulation of cell wall 1,3-alpha-glucan biosynthesis" EXACT [GOC:mah]
synonym: "regulation of cell wall 1,3-alpha-glucan biosynthetic process" EXACT [GOC:mah]
synonym: "regulation of cell wall 1,3-alpha-glucan formation" EXACT [GOC:mah]
synonym: "regulation of cell wall 1,3-alpha-glucan synthesis" EXACT [GOC:mah]
synonym: "regulation of cell wall alpha-1,3-glucan anabolism" EXACT [GOC:mah]
synonym: "regulation of cell wall alpha-1,3-glucan biosynthesis" EXACT [GOC:mah]
synonym: "regulation of cell wall alpha-1,3-glucan biosynthetic process" EXACT [GOC:mah]
synonym: "regulation of cell wall alpha-1,3-glucan formation" EXACT [GOC:mah]
synonym: "regulation of cell wall alpha-1,3-glucan synthesis" EXACT [GOC:mah]
is_a: GO:0010981 ! regulation of cell wall macromolecule metabolic process
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0070606 ! regulation of (1->3)-alpha-glucan biosynthetic process
is_a: GO:0070607 ! regulation of cell wall (1->3)-alpha-glucan metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070598 ! cell wall (1->3)-alpha-glucan biosynthetic process
relationship: regulates GO:0070598 ! cell wall (1->3)-alpha-glucan biosynthetic process
created_by: midori
creation_date: 2009-04-29T01:27:15Z

[Term]
id: GO:0070609
name: regulation of fungal-type cell wall (1->3)-alpha-glucan metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds, found in the walls of ascospores." [GOC:mah]
synonym: "regulation of ascospore wall 1,3-alpha-glucan metabolism" EXACT [GOC:mah]
synonym: "regulation of ascospore wall alpha-1,3 glucan metabolic process" EXACT [GOC:mah]
synonym: "regulation of ascospore wall alpha-1,3 glucan metabolism" EXACT [GOC:mah]
synonym: "regulation of fungal-type cell wall 1,3-alpha-glucan metabolic process" EXACT [GOC:mah]
is_a: GO:0070607 ! regulation of cell wall (1->3)-alpha-glucan metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070599 ! fungal-type cell wall (1->3)-alpha-glucan metabolic process
relationship: regulates GO:0070599 ! fungal-type cell wall (1->3)-alpha-glucan metabolic process
created_by: midori
creation_date: 2009-04-29T01:29:02Z

[Term]
id: GO:0070610
name: regulation of fungal-type cell wall (1->3)-alpha-glucan biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->3)-alpha glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds, found in fungal-type cell walls, including those of ascospores." [GOC:mah]
synonym: "regulation of fungal type cell wall 1,3-alpha-glucan biosynthetic process" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of fungal-type cell wall 1,3-alpha-glucan anabolism" EXACT [GOC:mah]
synonym: "regulation of fungal-type cell wall 1,3-alpha-glucan biosynthesis" EXACT [GOC:mah]
synonym: "regulation of fungal-type cell wall 1,3-alpha-glucan formation" EXACT [GOC:mah]
synonym: "regulation of fungal-type cell wall 1,3-alpha-glucan synthesis" EXACT [GOC:mah]
synonym: "regulation of fungal-type cell wall alpha-1,3-glucan anabolism" EXACT [GOC:mah]
synonym: "regulation of fungal-type cell wall alpha-1,3-glucan biosynthesis" EXACT [GOC:mah]
synonym: "regulation of fungal-type cell wall alpha-1,3-glucan biosynthetic process" EXACT [GOC:mah]
synonym: "regulation of fungal-type cell wall alpha-1,3-glucan formation" EXACT [GOC:mah]
synonym: "regulation of fungal-type cell wall alpha-1,3-glucan synthesis" EXACT [GOC:mah]
is_a: GO:0070608 ! regulation of cell wall (1->3)-alpha-glucan biosynthetic process
is_a: GO:0070609 ! regulation of fungal-type cell wall (1->3)-alpha-glucan metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070600 ! fungal-type cell wall (1->3)-alpha-glucan biosynthetic process
relationship: regulates GO:0070600 ! fungal-type cell wall (1->3)-alpha-glucan biosynthetic process
created_by: midori
creation_date: 2009-04-29T01:32:19Z

[Term]
id: GO:0070611
name: histone methyltransferase activity (H3-R2 specific)
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 2) = S-adenosyl-L-homocysteine + (histone H3)-N-methyl-arginine (position 2). This reaction is the addition of a methyl group to arginine at position 2 of histone H3." [EC:2.1.1.125, GOC:mah, PMID:17898714]
synonym: "histone methylase activity (H3-R2 specific)" EXACT [GOC:mah]
synonym: "histone-arginine N-methyltransferase activity (H3-R2 specific)" EXACT [GOC:mah]
is_a: GO:0008469 ! histone-arginine N-methyltransferase activity
relationship: part_of GO:0034970 ! histone H3-R2 methylation
created_by: midori
creation_date: 2009-04-29T02:04:44Z

[Term]
id: GO:0070612
name: histone methyltransferase activity (H2A-R3 specific)
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + (histone H2A)-arginine (position 3) = S-adenosyl-L-homocysteine + (histone H2A)-N-methyl-arginine (position 3). This reaction is the addition of a methyl group to arginine at position 3 of histone H2A." [EC:2.1.1.125, GOC:mah, PMID:17898714]
synonym: "histone methylase activity (H2A-R3 specific)" EXACT [GOC:mah]
synonym: "histone-arginine N-methyltransferase activity (H2A-R3 specific)" EXACT [GOC:mah]
is_a: GO:0008469 ! histone-arginine N-methyltransferase activity
created_by: midori
creation_date: 2009-04-29T02:06:45Z

[Term]
id: GO:0070613
name: regulation of protein processing
namespace: biological_process
alt_id: GO:0010953
def: "Any process that modulates the frequency, rate or extent of protein processing, any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein." [GOC:mah]
synonym: "regulation of protein maturation by peptide bond cleavage" EXACT []
is_a: GO:0030162 ! regulation of proteolysis
is_a: GO:1903317 ! regulation of protein maturation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016485 ! protein processing
relationship: regulates GO:0016485 ! protein processing
created_by: midori
creation_date: 2009-04-29T02:49:14Z

[Term]
id: GO:0070614
name: tungstate ion transport
namespace: biological_process
def: "The directed movement of tungstate (WO4 2-) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Tungstate is a bivalent oxoanion of tungsten." [GOC:dh]
subset: gosubset_prok
is_a: GO:0015698 ! inorganic anion transport
created_by: midori
creation_date: 2009-04-29T03:07:40Z

[Term]
id: GO:0070615
name: nucleosome-dependent ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of one or more nucleosomes." [GOC:mah, PMID:19165147]
synonym: "nucleosome-activated ATPase activity" EXACT [GOC:mah]
is_a: GO:0042623 ! ATPase activity, coupled
created_by: midori
creation_date: 2009-04-29T03:15:31Z

[Term]
id: GO:0070616
name: regulation of thiamine diphosphate biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamine diphosphate." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of thiamin diphosphate biosynthetic process" EXACT [GOC:curators]
synonym: "regulation of thiamine diphosphate anabolism" EXACT [GOC:mah]
synonym: "regulation of thiamine diphosphate biosynthesis" EXACT [GOC:mah]
synonym: "regulation of thiamine diphosphate formation" EXACT [GOC:mah]
synonym: "regulation of thiamine diphosphate synthesis" EXACT [GOC:mah]
is_a: GO:0019220 ! regulation of phosphate metabolic process
is_a: GO:0030656 ! regulation of vitamin metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
is_a: GO:0051196 ! regulation of coenzyme metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009229 ! thiamine diphosphate biosynthetic process
relationship: regulates GO:0009229 ! thiamine diphosphate biosynthetic process
created_by: midori
creation_date: 2009-04-29T03:37:35Z

[Term]
id: GO:0070617
name: negative regulation of thiamine diphosphate biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamine diphosphate." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation of thiamine diphosphate biosynthetic process" EXACT [GOC:mah]
synonym: "down-regulation of thiamine diphosphate biosynthetic process" EXACT [GOC:mah]
synonym: "downregulation of thiamine diphosphate biosynthetic process" EXACT [GOC:mah]
synonym: "inhibition of thiamine diphosphate biosynthetic process" NARROW [GOC:mah]
synonym: "negative regulation of thiamin diphosphate biosynthetic process" EXACT [GOC:curators]
synonym: "negative regulation of thiamine diphosphate anabolism" EXACT [GOC:mah]
synonym: "negative regulation of thiamine diphosphate biosynthesis" EXACT [GOC:mah]
synonym: "negative regulation of thiamine diphosphate formation" EXACT [GOC:mah]
synonym: "negative regulation of thiamine diphosphate synthesis" EXACT [GOC:mah]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0045936 ! negative regulation of phosphate metabolic process
is_a: GO:0046137 ! negative regulation of vitamin metabolic process
is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process
is_a: GO:0051175 ! negative regulation of sulfur metabolic process
is_a: GO:0051198 ! negative regulation of coenzyme metabolic process
is_a: GO:0070616 ! regulation of thiamine diphosphate biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009229 ! thiamine diphosphate biosynthetic process
relationship: negatively_regulates GO:0009229 ! thiamine diphosphate biosynthetic process
created_by: midori
creation_date: 2009-04-29T03:39:48Z

[Term]
id: GO:0070618
name: Grb2-Sos complex
namespace: cellular_component
def: "A protein complex that contains Grb2 and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway." [GOC:mah, PMID:7798267, PMID:8940013]
synonym: "Grb2-mSos1 complex" NARROW [CORUM:2545]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-04-29T04:19:02Z

[Term]
id: GO:0070619
name: Shc-Grb2-Sos complex
namespace: cellular_component
def: "A protein complex that contains Grb2, the adaptor protein Shc and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway." [GOC:mah, PMID:7970708, PMID:8940013]
synonym: "Shc-Grb2-mSos1 complex, EGF stimulated" NARROW [CORUM:2553]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-04-29T04:30:00Z

[Term]
id: GO:0070620
name: EGFR-Grb2-Sos complex
namespace: cellular_component
def: "A protein complex that contains the epidermal growth factor receptor (EGFR), Grb2 and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway." [GOC:mah, PMID:7798267, PMID:8940013]
synonym: "Egfr-Grb2-mSos1 complex, EGF stimulated" NARROW [CORUM:2548]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-04-29T04:36:30Z

[Term]
id: GO:0070621
name: EGFR-Shc-Grb2-Sos complex
namespace: cellular_component
def: "A protein complex that contains the epidermal growth factor receptor (EGFR), Grb2, the adaptor protein SHC and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway." [GOC:mah, PMID:7798267, PMID:8940013]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-04-29T04:38:10Z

[Term]
id: GO:0070622
name: UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complex
namespace: cellular_component
def: "A protein complex that possesses UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity; the bovine complex contains disulfide-linked homodimers of 166- and 51-kDa subunits and two identical, noncovalently associated 56-kDa subunits." [GOC:mah, PMID:8940155]
synonym: "N-acetylglucosamine-1-phosphotransferase complex" RELATED [CORUM:406]
synonym: "UDP-N-acetylglucosamine:lysosomal-enzyme N-acetylglucosamine-1-phosphotransferase complex" EXACT [PMID:8940155]
is_a: GO:0044437 ! vacuolar part
is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups
relationship: part_of GO:0005764 ! lysosome
created_by: midori
creation_date: 2009-04-29T04:50:35Z

[Term]
id: GO:0070623
name: regulation of thiamine biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamine." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of thiamin biosynthetic process" EXACT [GOC:curators]
synonym: "regulation of thiamine anabolism" EXACT [GOC:mah]
synonym: "regulation of thiamine biosynthesis" EXACT [GOC:mah]
synonym: "regulation of thiamine formation" EXACT [GOC:mah]
synonym: "regulation of thiamine synthesis" EXACT [GOC:mah]
is_a: GO:0030656 ! regulation of vitamin metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009228 ! thiamine biosynthetic process
relationship: regulates GO:0009228 ! thiamine biosynthetic process
created_by: midori
creation_date: 2009-05-01T03:15:49Z

[Term]
id: GO:0070624
name: negative regulation of thiamine biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamine." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation of thiamine biosynthetic process" EXACT [GOC:mah]
synonym: "down-regulation of thiamine biosynthetic process" EXACT [GOC:mah]
synonym: "downregulation of thiamine biosynthetic process" EXACT [GOC:mah]
synonym: "inhibition of thiamine biosynthetic process" NARROW [GOC:mah]
synonym: "negative regulation of thiamin biosynthetic process" EXACT [GOC:curators]
synonym: "negative regulation of thiamine anabolism" EXACT [GOC:mah]
synonym: "negative regulation of thiamine biosynthesis" EXACT [GOC:mah]
synonym: "negative regulation of thiamine formation" EXACT [GOC:mah]
synonym: "negative regulation of thiamine synthesis" EXACT [GOC:mah]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0046137 ! negative regulation of vitamin metabolic process
is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process
is_a: GO:0051175 ! negative regulation of sulfur metabolic process
is_a: GO:0070623 ! regulation of thiamine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009228 ! thiamine biosynthetic process
relationship: negatively_regulates GO:0009228 ! thiamine biosynthetic process
created_by: midori
creation_date: 2009-05-01T03:20:41Z

[Term]
id: GO:0070625
name: zymogen granule exocytosis
namespace: biological_process
def: "The release of intracellular molecules contained within the zymogen granule by fusion of the granule with the plasma membrane of the oocyte, requiring calcium ions." [GOC:BHF, GOC:vk, PMID:17442889]
is_a: GO:0017156 ! calcium ion regulated exocytosis
created_by: midori
creation_date: 2009-05-01T03:56:02Z

[Term]
id: GO:0070626
name: (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide." [GOC:mah, GOC:pde]
subset: gosubset_prok
synonym: "adenylosuccinase activity" BROAD [EC:4.3.2.2, GOC:mah]
synonym: "adenylosuccinate lyase activity" BROAD [GOC:mah]
synonym: "succino AMP-lyase activity" BROAD [EC:4.3.2.2, GOC:mah]
xref: EC:4.3.2.2
xref: KEGG:R04559
xref: MetaCyc:AICARSYN-RXN
xref: Reactome:REACT_116138 "5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) <=> 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + fumarate, Gallus gallus"
is_a: GO:0016842 ! amidine-lyase activity
created_by: midori
creation_date: 2009-05-01T04:13:49Z

[Term]
id: GO:0070627
name: ferrous iron import
namespace: biological_process
def: "The directed movement of ferrous iron (Fe(II) or Fe2+) ions across a membrane into a cell or organelle." [GOC:mah]
synonym: "ferrous ion import" EXACT []
synonym: "ferrous iron uptake" EXACT []
is_a: GO:0015684 ! ferrous iron transport
is_a: GO:0097286 ! iron ion import
created_by: midori
creation_date: 2009-05-01T04:19:14Z

[Term]
id: GO:0070628
name: proteasome binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a proteasome, a large multisubunit protein complex that catalyzes protein degradation." [GOC:mah]
subset: goslim_chembl
is_a: GO:0032403 ! protein complex binding
created_by: midori
creation_date: 2009-05-01T04:38:58Z

[Term]
id: GO:0070629
name: (1->4)-alpha-glucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (1->4)-alpha-glucans, compounds composed of glucose residues linked by (1->4)-alpha-D-glucosidic bonds." [GOC:mah]
subset: gosubset_prok
synonym: "(1->4)-alpha-D-glucan metabolism" EXACT [GOC:mah]
synonym: "1,4-alpha-D-glucan metabolism" EXACT [GOC:mah]
synonym: "1,4-alpha-glucan metabolism" EXACT [GOC:mah]
synonym: "alpha-1,4 glucan metabolic process" EXACT [GOC:mah]
synonym: "alpha-1,4 glucan metabolism" EXACT [GOC:mah]
is_a: GO:0030978 ! alpha-glucan metabolic process
created_by: midori
creation_date: 2009-05-01T04:45:42Z

[Term]
id: GO:0070630
name: (1->4)-alpha-glucan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (1->4)-alpha-glucans, compounds composed of glucose residues linked by (1->4)-alpha-D-glucosidic bonds." [GOC:mah]
synonym: "(1->4)-alpha-D-glucan anabolism" EXACT [GOC:mah]
synonym: "(1->4)-alpha-D-glucan biosynthesis" EXACT [GOC:mah]
synonym: "(1->4)-alpha-D-glucan formation" EXACT [GOC:mah]
synonym: "(1->4)-alpha-D-glucan synthesis" EXACT [GOC:mah]
synonym: "1,4-alpha-glucan anabolism" EXACT [GOC:mah]
synonym: "1,4-alpha-glucan biosynthesis" EXACT [GOC:mah]
synonym: "1,4-alpha-glucan biosynthetic process" EXACT [GOC:mah]
synonym: "1,4-alpha-glucan formation" EXACT [GOC:mah]
synonym: "1,4-alpha-glucan synthesis" EXACT [GOC:mah]
synonym: "alpha-1,4 glucan anabolism" EXACT [GOC:mah]
synonym: "alpha-1,4 glucan biosynthesis" EXACT [GOC:mah]
synonym: "alpha-1,4 glucan biosynthetic process" EXACT [GOC:mah]
synonym: "alpha-1,4 glucan formation" EXACT [GOC:mah]
synonym: "alpha-1,4 glucan synthesis" EXACT [GOC:mah]
is_a: GO:0030979 ! alpha-glucan biosynthetic process
is_a: GO:0070629 ! (1->4)-alpha-glucan metabolic process
created_by: midori
creation_date: 2009-05-01T04:46:34Z

[Term]
id: GO:0070631
name: spindle pole body localization
namespace: biological_process
def: "Any process in which a spindle pole body is transported to, or maintained in, a specific location. A spindle pole body is a type of microtubule organizing center found in fungal cells." [GOC:mah]
synonym: "establishment and maintenance of spindle pole body localization" EXACT [GOC:mah]
synonym: "spindle pole body localisation" EXACT [GOC:mah]
is_a: GO:0051641 ! cellular localization
created_by: midori
creation_date: 2009-05-06T02:21:38Z

[Term]
id: GO:0070632
name: establishment of spindle pole body localization
namespace: biological_process
def: "Any process in which a spindle pole body is transported to a specific location. A spindle pole body is a type of microtubule organizing center found in fungal cells." [GOC:mah]
synonym: "establishment of spindle pole body localisation" EXACT [GOC:mah]
synonym: "spindle pole body positioning" EXACT [GOC:vw]
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0070631 ! spindle pole body localization
created_by: midori
creation_date: 2009-05-06T02:35:32Z

[Term]
id: GO:0070633
name: transepithelial transport
namespace: biological_process
def: "The directed movement of a substance from one side of an epithelium to the other." [GOC:mah, GOC:yaf, ISBN:0716731363]
is_a: GO:0044765 ! single-organism transport
created_by: midori
creation_date: 2009-05-06T03:31:02Z

[Term]
id: GO:0070634
name: transepithelial ammonium transport
namespace: biological_process
def: "The directed movement of ammonium ions from one side of an epithelium to the other." [GOC:mah, GOC:yaf]
is_a: GO:0015696 ! ammonium transport
is_a: GO:0070633 ! transepithelial transport
created_by: midori
creation_date: 2009-05-06T03:34:43Z

[Term]
id: GO:0070635
name: nicotinamide riboside hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: nicotinamide riboside + H2O = nicotinamide + D-ribose." [MetaCyc:RXN-8441, PMID:19001417]
synonym: "N-ribosylnicotinamide hydrolase activity" EXACT [CHEBI:15927]
synonym: "nicotinamide ribonucleoside hydrolase activity" EXACT [CHEBI:15927]
xref: EC:3.2.2.-
xref: MetaCyc:RXN-8441
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds
created_by: midori
creation_date: 2009-05-07T02:01:42Z

[Term]
id: GO:0070636
name: nicotinic acid riboside hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: nicotinic acid riboside + H2O = nicotinic acid + D-ribose." [GOC:mah, PMID:19001417]
synonym: "D-ribosylnicotinate hydrolase activity" EXACT [GOC:mah]
synonym: "D-ribosylnicotinic acid hydrolase activity" EXACT [CHEBI:27748]
synonym: "nicotinate ribonucleoside hydrolase activity" EXACT [GOC:mah]
synonym: "nicotinate riboside hydrolase activity" EXACT [GOC:mah]
synonym: "nicotinic acid ribonucleoside hydrolase activity" EXACT [GOC:mah]
xref: EC:3.2.2.-
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds
created_by: midori
creation_date: 2009-05-07T02:12:00Z

[Term]
id: GO:0070637
name: pyridine nucleoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any pyridine nucleoside, a nucleoside in which a pyridine base covalently bonded to a sugar, usually ribose." [CHEBI:47896, GOC:mah]
subset: gosubset_prok
synonym: "pyridine nucleoside metabolism" EXACT [GOC:mah]
is_a: GO:0009116 ! nucleoside metabolic process
is_a: GO:0072524 ! pyridine-containing compound metabolic process
created_by: midori
creation_date: 2009-05-07T02:24:21Z

[Term]
id: GO:0070638
name: pyridine nucleoside catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any pyridine nucleoside, a nucleoside in which a pyridine base covalently bonded to a sugar, usually ribose." [CHEBI:47896, GOC:mah]
subset: gosubset_prok
synonym: "pyridine nucleoside breakdown" EXACT [GOC:mah]
synonym: "pyridine nucleoside catabolism" EXACT [GOC:mah]
synonym: "pyridine nucleoside degradation" EXACT [GOC:mah]
is_a: GO:0009164 ! nucleoside catabolic process
is_a: GO:0070637 ! pyridine nucleoside metabolic process
is_a: GO:0072526 ! pyridine-containing compound catabolic process
created_by: midori
creation_date: 2009-05-07T02:27:14Z

[Term]
id: GO:0070639
name: vitamin D2 metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving vitamin D2, (3S,5Z,7E,22E)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol." [CHEBI:28934, GOC:BHF, GOC:mah]
synonym: "calciferol metabolic process" EXACT [CHEBI:28934]
synonym: "ergocalciferol metabolic process" EXACT [CHEBI:28934]
synonym: "vitamin D2 metabolism" EXACT [GOC:mah]
is_a: GO:0042359 ! vitamin D metabolic process
created_by: midori
creation_date: 2009-05-08T02:11:35Z

[Term]
id: GO:0070640
name: vitamin D3 metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving vitamin D3, (3S,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol." [CHEBI:28940, GOC:BHF, GOC:mah]
synonym: "calciol metabolic process" EXACT [CHEBI:28940]
synonym: "cholecalciferol metabolic process" EXACT [CHEBI:28940]
synonym: "vitamin D3 metabolism" EXACT [GOC:mah]
is_a: GO:0042359 ! vitamin D metabolic process
is_a: GO:1902652 ! secondary alcohol metabolic process
created_by: midori
creation_date: 2009-05-08T02:24:24Z

[Term]
id: GO:0070641
name: vitamin D4 metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving vitamin D4, (3S,5Z,7E)-9,10-secoergosta-5,7,10(19)-trien-3-ol." [CHEBI:33237, GOC:BHF, GOC:mah]
synonym: "vitamin D4 metabolism" EXACT [GOC:mah]
is_a: GO:0042359 ! vitamin D metabolic process
created_by: midori
creation_date: 2009-05-08T02:33:01Z

[Term]
id: GO:0070642
name: vitamin D5 metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving vitamin D5, (1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,4S)-4-ethyl-1,5-dimethylhexyl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylene-1-cyclohexanol." [GOC:BHF, GOC:mah, PubChem_Compound:9547700]
synonym: "vitamin D5 metabolism" EXACT [GOC:mah]
is_a: GO:0042359 ! vitamin D metabolic process
created_by: midori
creation_date: 2009-05-08T02:47:41Z

[Term]
id: GO:0070643
name: vitamin D 25-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the hydroxylation of C-25 of any form of vitamin D." [GOC:BHF, GOC:mah]
synonym: "calciferol 25-hydroxylase activity" NARROW [GOC:mah]
synonym: "cholecalciferol 25-hydroxylase activity" NARROW [GOC:mah]
synonym: "ergocalciferol 25-hydroxylase activity" NARROW [GOC:mah]
synonym: "vitamin D2 25-hydroxylase activity" NARROW [GOC:mah]
is_a: GO:0016491 ! oxidoreductase activity
created_by: midori
creation_date: 2009-05-08T03:42:29Z

[Term]
id: GO:0070644
name: vitamin D response element binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the vitamin D response element (VDRE), a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum." [GOC:BHF, GOC:vk, PMID:17426122]
comment: Note that as agreed during the transcription overhaul, terms specifying binding to specific transcription regulatory motifs are no longer being created. The level of specificity GO has decided to go to is the "core promoter", "core promoter proximal region" and "enhancer". To capture more detail, please consider using column 16.
synonym: "VDRE binding" EXACT [GOC:vk, PMID:17426122]
is_a: GO:0044212 ! transcription regulatory region DNA binding
created_by: midori
creation_date: 2009-05-08T04:23:44Z

[Term]
id: GO:0070645
name: Ubisch body
namespace: cellular_component
def: "A small, granular structure that is found in the extracellular matrix of cell of the secretory tapetal layer that surrounds developing pollen grains. Ubisch bodies have a sporopollenin coat, are attached to the peritapetal wall, and may play a role in pollen development." [GOC:ecd, GOC:mah, PMID:14612572, PMID:16524248]
synonym: "orbicule" EXACT [PMID:14612572]
is_a: GO:0044420 ! extracellular matrix component
created_by: midori
creation_date: 2009-05-11T11:35:33Z

[Term]
id: GO:0070646
name: protein modification by small protein removal
namespace: biological_process
def: "A protein modification process in which one or more covalently attached groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are removed from a target protein." [GOC:mah]
is_a: GO:0006508 ! proteolysis
is_a: GO:0070647 ! protein modification by small protein conjugation or removal
created_by: midori
creation_date: 2009-05-11T01:58:15Z

[Term]
id: GO:0070647
name: protein modification by small protein conjugation or removal
namespace: biological_process
def: "A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to or removed from a target protein." [GOC:mah]
subset: goslim_pombe
subset: goslim_yeast
is_a: GO:0006464 ! cellular protein modification process
created_by: midori
creation_date: 2009-05-11T02:54:03Z

[Term]
id: GO:0070648
name: formin-nucleated actin cable
namespace: cellular_component
def: "An actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins. In fungal cells, myosin motors transport cargo along actin cables toward sites of polarized cell growth; actin cables may play a similar role in pollen tube growth." [PMID:14671023, PMID:16959963]
is_a: GO:0097518 ! parallel actin filament bundle
created_by: midori
creation_date: 2009-05-12T02:09:57Z

[Term]
id: GO:0070649
name: formin-nucleated actin cable assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins." [GOC:mah, PMID:14671023, PMID:16959963]
synonym: "formin-nucleated actin cable formation" EXACT [GOC:mah]
is_a: GO:0030046 ! parallel actin filament bundle assembly
created_by: midori
creation_date: 2009-05-12T02:14:36Z

[Term]
id: GO:0070650
name: actin filament bundle distribution
namespace: biological_process
def: "Any cellular process that establishes the spatial arrangement of actin filament bundles within the cell." [GOC:mah]
is_a: GO:0061572 ! actin filament bundle organization
created_by: midori
creation_date: 2009-05-12T02:20:58Z

[Term]
id: GO:0070651
name: nonfunctional rRNA decay
namespace: biological_process
def: "An rRNA catabolic process that results in the targeted detection and degradation of aberrant rRNAs contained within translationally defective ribosomes, thereby acting as a quality-control system." [GOC:mah, GOC:rn, PMID:17188037, PMID:19390089]
synonym: "NRD" RELATED [GOC:rn]
is_a: GO:0016075 ! rRNA catabolic process
created_by: midori
creation_date: 2009-05-28T02:22:49Z

[Term]
id: GO:0070652
name: HAUS complex
namespace: cellular_component
def: "A protein complex that localizes to interphase centrosomes and to mitotic spindle tubules and regulates mitotic spindle assembly and centrosome integrity; in human, the complex consists of eight subunits, some of which are homologous to subunits of the Drosophila Augmin complex." [PMID:19427217]
synonym: "HAUS augmin complex" EXACT [GOC:mm2]
is_a: GO:0005875 ! microtubule associated complex
created_by: midori
creation_date: 2009-05-28T03:21:01Z

[Term]
id: GO:0070653
name: high-density lipoprotein particle receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a high-density lipoprotein receptor." [GOC:BHF, GOC:mah]
synonym: "HDL receptor binding" EXACT [GOC:mah]
synonym: "high-density lipoprotein receptor binding" EXACT [GOC:dph]
is_a: GO:0070325 ! lipoprotein particle receptor binding
created_by: midori
creation_date: 2009-05-28T03:44:33Z

[Term]
id: GO:0070654
name: sensory epithelium regeneration
namespace: biological_process
def: "The regrowth of a sensory epithelium following its loss or destruction." [GOC:dsf, PMID:19381250]
is_a: GO:1990399 ! epithelium regeneration
created_by: midori
creation_date: 2009-05-28T04:02:27Z

[Term]
id: GO:0070655
name: mechanosensory epithelium regeneration
namespace: biological_process
def: "The regrowth of lost or destroyed mechanosensory epithelia." [GOC:dsf, PMID:19381250]
is_a: GO:0070654 ! sensory epithelium regeneration
created_by: midori
creation_date: 2009-05-28T04:05:18Z

[Term]
id: GO:0070656
name: mechanoreceptor differentiation involved in mechanosensory epithelium regeneration
namespace: biological_process
def: "Differentiation of new mechanoreceptors to replace those lost or destroyed by injury." [GOC:dsf, PMID:19381250]
is_a: GO:0042490 ! mechanoreceptor differentiation
intersection_of: GO:0042490 ! mechanoreceptor differentiation
intersection_of: part_of GO:0070655 ! mechanosensory epithelium regeneration
relationship: part_of GO:0070655 ! mechanosensory epithelium regeneration
created_by: midori
creation_date: 2009-05-28T04:08:13Z

[Term]
id: GO:0070657
name: neuromast regeneration
namespace: biological_process
def: "The regrowth of a neuromast following its loss or destruction." [GOC:dsf, PMID:19381250]
is_a: GO:0070655 ! mechanosensory epithelium regeneration
created_by: midori
creation_date: 2009-05-28T04:11:44Z

[Term]
id: GO:0070658
name: neuromast hair cell differentiation involved in neuromast regeneration
namespace: biological_process
def: "Differentiation of new neuromast sensory hair cells to replace those lost or destroyed by injury." [GOC:dsf, PMID:19381250]
is_a: GO:0048886 ! neuromast hair cell differentiation
is_a: GO:0070656 ! mechanoreceptor differentiation involved in mechanosensory epithelium regeneration
intersection_of: GO:0048886 ! neuromast hair cell differentiation
intersection_of: part_of GO:0070657 ! neuromast regeneration
relationship: part_of GO:0070657 ! neuromast regeneration
created_by: midori
creation_date: 2009-05-28T04:16:27Z

[Term]
id: GO:0070659
name: inner ear sensory epithelium regeneration
namespace: biological_process
def: "The regrowth of lost or destroyed inner ear sensory epithelia." [GOC:dsf, PMID:19381250]
is_a: GO:0070655 ! mechanosensory epithelium regeneration
created_by: midori
creation_date: 2009-05-28T04:21:09Z

[Term]
id: GO:0070660
name: inner ear receptor cell differentiation involved in inner ear sensory epithelium regeneration
namespace: biological_process
def: "Differentiation of new inner ear sensory hair cells to replace those lost or destroyed by injury." [GOC:dsf, PMID:19381250]
is_a: GO:0060113 ! inner ear receptor cell differentiation
is_a: GO:0070656 ! mechanoreceptor differentiation involved in mechanosensory epithelium regeneration
intersection_of: GO:0060113 ! inner ear receptor cell differentiation
intersection_of: part_of GO:0070659 ! inner ear sensory epithelium regeneration
relationship: part_of GO:0070659 ! inner ear sensory epithelium regeneration
created_by: midori
creation_date: 2009-05-28T04:24:23Z

[Term]
id: GO:0070661
name: leukocyte proliferation
namespace: biological_process
def: "The expansion of a leukocyte population by cell division." [GOC:add]
is_a: GO:0008283 ! cell proliferation
created_by: midori
creation_date: 2009-05-28T05:25:28Z

[Term]
id: GO:0070662
name: mast cell proliferation
namespace: biological_process
def: "The expansion of a mast cell population by cell division." [GOC:add]
is_a: GO:0070661 ! leukocyte proliferation
created_by: midori
creation_date: 2009-05-28T05:27:51Z

[Term]
id: GO:0070663
name: regulation of leukocyte proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of leukocyte proliferation." [GOC:add, GOC:mah]
is_a: GO:0042127 ! regulation of cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070661 ! leukocyte proliferation
relationship: regulates GO:0070661 ! leukocyte proliferation
created_by: midori
creation_date: 2009-05-28T05:30:39Z

[Term]
id: GO:0070664
name: negative regulation of leukocyte proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte proliferation." [GOC:add, GOC:mah]
synonym: "down regulation of leukocyte proliferation" EXACT [GOC:mah]
synonym: "down-regulation of leukocyte proliferation" EXACT [GOC:mah]
synonym: "downregulation of leukocyte proliferation" EXACT [GOC:mah]
synonym: "inhibition of leukocyte proliferation" NARROW [GOC:mah]
is_a: GO:0008285 ! negative regulation of cell proliferation
is_a: GO:0070663 ! regulation of leukocyte proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070661 ! leukocyte proliferation
relationship: negatively_regulates GO:0070661 ! leukocyte proliferation
created_by: midori
creation_date: 2009-05-28T05:34:50Z

[Term]
id: GO:0070665
name: positive regulation of leukocyte proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of leukocyte proliferation." [GOC:add, GOC:mah]
synonym: "activation of leukocyte proliferation" NARROW [GOC:mah]
synonym: "stimulation of leukocyte proliferation" NARROW [GOC:mah]
synonym: "up regulation of leukocyte proliferation" EXACT [GOC:mah]
synonym: "up-regulation of leukocyte proliferation" EXACT [GOC:mah]
synonym: "upregulation of leukocyte proliferation" EXACT [GOC:mah]
is_a: GO:0008284 ! positive regulation of cell proliferation
is_a: GO:0070663 ! regulation of leukocyte proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070661 ! leukocyte proliferation
relationship: positively_regulates GO:0070661 ! leukocyte proliferation
created_by: midori
creation_date: 2009-05-28T05:36:46Z

[Term]
id: GO:0070666
name: regulation of mast cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mast cell proliferation." [GOC:add, GOC:mah]
is_a: GO:0070663 ! regulation of leukocyte proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070662 ! mast cell proliferation
relationship: regulates GO:0070662 ! mast cell proliferation
created_by: midori
creation_date: 2009-05-28T05:40:43Z

[Term]
id: GO:0070667
name: negative regulation of mast cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of mast cell proliferation." [GOC:add, GOC:mah]
synonym: "down regulation of mast cell proliferation" EXACT [GOC:mah]
synonym: "down-regulation of mast cell proliferation" EXACT [GOC:mah]
synonym: "downregulation of mast cell proliferation" EXACT [GOC:mah]
synonym: "inhibition of mast cell proliferation" NARROW [GOC:mah]
is_a: GO:0070664 ! negative regulation of leukocyte proliferation
is_a: GO:0070666 ! regulation of mast cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070662 ! mast cell proliferation
relationship: negatively_regulates GO:0070662 ! mast cell proliferation
created_by: midori
creation_date: 2009-05-28T05:45:11Z

[Term]
id: GO:0070668
name: positive regulation of mast cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of mast cell proliferation." [GOC:add, GOC:mah]
synonym: "activation of mast cell proliferation" NARROW [GOC:mah]
synonym: "stimulation of mast cell proliferation" NARROW [GOC:mah]
synonym: "up regulation of mast cell proliferation" EXACT [GOC:mah]
synonym: "up-regulation of mast cell proliferation" EXACT [GOC:mah]
synonym: "upregulation of mast cell proliferation" EXACT [GOC:mah]
is_a: GO:0070665 ! positive regulation of leukocyte proliferation
is_a: GO:0070666 ! regulation of mast cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070662 ! mast cell proliferation
relationship: positively_regulates GO:0070662 ! mast cell proliferation
created_by: midori
creation_date: 2009-05-28T05:48:30Z

[Term]
id: GO:0070669
name: response to interleukin-2
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-2 stimulus." [GOC:mah]
synonym: "response to IL-2" EXACT [GOC:mah]
is_a: GO:0034097 ! response to cytokine
created_by: midori
creation_date: 2009-05-29T09:59:43Z

[Term]
id: GO:0070670
name: response to interleukin-4
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus." [GOC:mah]
synonym: "response to IL-4" EXACT [GOC:mah]
is_a: GO:0034097 ! response to cytokine
created_by: midori
creation_date: 2009-05-29T10:01:46Z

[Term]
id: GO:0070671
name: response to interleukin-12
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-12 stimulus." [GOC:mah]
synonym: "response to IL-12" EXACT [GOC:mah]
is_a: GO:0034097 ! response to cytokine
created_by: midori
creation_date: 2009-05-29T10:02:31Z

[Term]
id: GO:0070672
name: response to interleukin-15
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-15 stimulus." [GOC:mah]
synonym: "response to IL-15" EXACT [GOC:mah]
is_a: GO:0034097 ! response to cytokine
created_by: midori
creation_date: 2009-05-29T10:03:09Z

[Term]
id: GO:0070673
name: response to interleukin-18
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-18 stimulus." [GOC:mah]
synonym: "response to IL-18" EXACT [GOC:mah]
is_a: GO:0034097 ! response to cytokine
created_by: midori
creation_date: 2009-05-29T10:03:52Z

[Term]
id: GO:0070674
name: hypoxanthine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: hypoxanthine + NAD+ + H2O = xanthine + NADH + H+." [GOC:mah, GOC:pde]
subset: gosubset_prok
synonym: "hypoxanthine oxidoreductase activity" BROAD [EC:1.17.1.4]
synonym: "hypoxanthine-NAD oxidoreductase activity" EXACT [EC:1.17.1.4]
synonym: "hypoxanthine/NAD(+) oxidoreductase activity" EXACT [EC:1.17.1.4]
synonym: "hypoxanthine/NAD+ oxidoreductase activity" EXACT [EC:1.17.1.4]
synonym: "hypoxanthine:NAD+ oxidoreductase activity" EXACT [EC:1.17.1.4]
synonym: "NAD-hypoxanthine dehydrogenase activity" EXACT [EC:1.17.1.4]
xref: Reactome:REACT_115928 "hypoxanthine + H2O + NAD+ => xanthine + NADH + H+, Gallus gallus"
is_a: GO:0016726 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor
created_by: midori
creation_date: 2009-05-29T01:02:13Z

[Term]
id: GO:0070675
name: hypoxanthine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: hypoxanthine + H2O + O2 = xanthine + H2O2." [GOC:mah, GOC:pde]
subset: gosubset_prok
synonym: "hypoxanthine-xanthine oxidase activity" BROAD [EC:1.17.3.2]
synonym: "hypoxanthine:O(2) oxidoreductase activity" EXACT [EC:1.17.3.2]
synonym: "hypoxanthine:O2 oxidoreductase activity" EXACT [EC:1.17.3.2]
synonym: "hypoxanthine:oxygen oxidoreductase activity" EXACT [EC:1.17.3.2]
synonym: "schardinger enzyme" RELATED [EC:1.17.3.2]
synonym: "Schardinger enzyme activity" RELATED [EC:1.17.3.2]
synonym: "xanthine oxidoreductase activity" BROAD [EC:1.17.3.2]
is_a: GO:0016727 ! oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor
created_by: midori
creation_date: 2009-05-29T01:12:55Z

[Term]
id: GO:0070676
name: intralumenal vesicle formation
namespace: biological_process
def: "The evagination of the endosome membrane, resulting in the formation of a vesicle." [GOC:jp, PMID:19234443]
synonym: "endosome membrane budding" EXACT [GOC:jp, GOC:mah]
is_a: GO:0051668 ! localization within membrane
is_a: GO:1902580 ! single-organism cellular localization
is_a: GO:1902582 ! single-organism intracellular transport
is_a: GO:1902591 ! single-organism membrane budding
intersection_of: GO:0006900 ! membrane budding
intersection_of: occurs_in GO:0010008 ! endosome membrane
relationship: occurs_in GO:0010008 ! endosome membrane
created_by: midori
creation_date: 2009-05-29T02:02:30Z

[Term]
id: GO:0070677
name: rRNA (cytosine-2'-O-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methylcytosine." [GOC:mah, PMID:19400805]
subset: gosubset_prok
xref: EC:2.1.1.-
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0016434 ! rRNA (cytosine) methyltransferase activity
created_by: midori
creation_date: 2009-05-29T03:37:53Z

[Term]
id: GO:0070678
name: preprotein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a preprotein, the unprocessed form of a protein destined to undergo co- or post-translational processing." [GOC:imk, GOC:mah, PMID:12914940]
synonym: "unprocessed protein binding" EXACT [GOC:imk]
is_a: GO:0005515 ! protein binding
created_by: midori
creation_date: 2009-05-29T03:41:54Z

[Term]
id: GO:0070679
name: inositol 1,4,5 trisphosphate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with inositol 1,4,5 trisphosphate." [GOC:BHF, GOC:mah]
subset: gosubset_prok
synonym: "InsP3 binding" EXACT [GOC:mah]
synonym: "IP3 binding" EXACT [GOC:mah]
is_a: GO:0043168 ! anion binding
is_a: GO:0043178 ! alcohol binding
created_by: midori
creation_date: 2009-05-29T04:07:00Z

[Term]
id: GO:0070680
name: asparaginyl-tRNAAsn biosynthesis via transamidation
namespace: biological_process
def: "A tRNA aminoacylation process in which asparaginyl-tRNAAsn is formed by a tRNA-dependent two-step pathway. In the first step a non-discriminating aspartyl-tRNA synthetase generates the misacylated L-aspartyl-tRNAAsn species, and in the second step it is amidated to the correctly charged L-asparaginyl-tRNAAsn by the heterotrimeric aspartyl-tRNAAsn amidotransferase." [GOC:mah, MetaCyc:PWY490-4]
xref: MetaCyc:PWY490-4
is_a: GO:0043039 ! tRNA aminoacylation
created_by: midori
creation_date: 2009-06-02T03:11:19Z

[Term]
id: GO:0070681
name: glutaminyl-tRNAGln biosynthesis via transamidation
namespace: biological_process
def: "A tRNA aminoacylation process in which glutaminyl-tRNAGln is formed by a tRNA-dependent two-step pathway. In the first step a non-discriminating glutamyl-tRNAGlx synthetase generates the misacylated L-glutamyl-tRNAGln species, and in the second step it is amidated to the correctly charged L-glutaminyl-tRNAGln by a glutamyl-tRNAGln amidotransferase." [GOC:mah, MetaCyc:PWY-5921]
xref: MetaCyc:PWY-5921
is_a: GO:0043039 ! tRNA aminoacylation
created_by: midori
creation_date: 2009-06-02T03:15:57Z

[Term]
id: GO:0070682
name: proteasome regulatory particle assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a mature, active proteasome regulatory particle complex." [GOC:mah, GOC:rb, PMID:19412159]
synonym: "proteasome regulatory complex assembly" EXACT [GOC:mah]
is_a: GO:0043248 ! proteasome assembly
created_by: midori
creation_date: 2009-06-02T03:46:29Z

[Term]
id: GO:0070684
name: seminal clot liquefaction
namespace: biological_process
def: "The reproductive process in which coagulated semen becomes liquid following ejaculation, allowing the progressive release of motile spermatozoa." [GOC:mah, PMID:18482984]
synonym: "semen liquefaction" EXACT [PMID:18482984]
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0048609 ! multicellular organismal reproductive process
relationship: part_of GO:0007320 ! insemination
created_by: midori
creation_date: 2009-06-02T04:33:54Z

[Term]
id: GO:0070685
name: macropinocytic cup
namespace: cellular_component
def: "A cell projection that forms at the site of macropinocytosis, a form of endocytosis that results in the uptake of relatively large amounts of extracellular fluid. The macropinocytic cup membrane selectively excludes certain proteins, such as H36 or PM4C4 in Dictyostelium, and the underlying cytoskeleton is enriched in F-actin and coronin." [PMID:12538772, PMID:16968738, PMID:9044041]
synonym: "crown" EXACT [GOC:pf, PMID:9044041]
is_a: GO:0042995 ! cell projection
created_by: midori
creation_date: 2009-06-03T10:18:00Z

[Term]
id: GO:0070686
name: macropinocytic cup membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a macropinocytic cup." [GOC:mah]
synonym: "crown membrane" EXACT [GOC:mah]
is_a: GO:0031253 ! cell projection membrane
relationship: part_of GO:0070685 ! macropinocytic cup
created_by: midori
creation_date: 2009-06-03T10:52:25Z

[Term]
id: GO:0070687
name: macropinocytic cup cytoskeleton
namespace: cellular_component
def: "The part of the cortical actin cytoskeleton that forms part of a macropinocytic cup." [GOC:mah]
synonym: "crown cytoskeleton" EXACT [GOC:mah]
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044448 ! cell cortex part
is_a: GO:0044463 ! cell projection part
relationship: part_of GO:0030864 ! cortical actin cytoskeleton
relationship: part_of GO:0070685 ! macropinocytic cup
created_by: midori
creation_date: 2009-06-03T10:59:50Z

[Term]
id: GO:0070688
name: MLL5-L complex
namespace: cellular_component
def: "A protein complex that can methylate lysine-4 of histone H3 and plays an essential role in retinoic-acid-induced granulopoiesis. MLL5 is the catalytic methyltransferase subunit, and the complex also contains serine/threonine kinase 38 (STK38), protein phosphatase 1 catalytic subunits, the host cell factor-1 N-terminal subunit, beta-actin, and O-GlcNAc transferase; the human genes encoding the subunits are MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT, respectively." [GOC:mah, PMID:19377461]
is_a: GO:0035097 ! histone methyltransferase complex
created_by: midori
creation_date: 2009-06-03T11:50:18Z

[Term]
id: GO:0070689
name: L-threonine catabolic process to propionate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) to form the compound propionate." [GOC:bf, GOC:mah, MetaCyc:PWY-5437]
subset: gosubset_prok
synonym: "L-threonine breakdown to propionate" EXACT [GOC:bf, GOC:mah]
synonym: "L-threonine catabolism to propionate" EXACT [GOC:bf, GOC:mah]
synonym: "L-threonine degradation to propionate" EXACT [GOC:bf, GOC:mah]
synonym: "threonine catabolic process to propionate" BROAD [GOC:bf]
xref: MetaCyc:PWY-5437
is_a: GO:0006567 ! threonine catabolic process
is_a: GO:0019541 ! propionate metabolic process
created_by: midori
creation_date: 2009-06-03T01:36:54Z

[Term]
id: GO:0070690
name: L-threonine catabolic process to acetyl-CoA
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) into glycine and acetaldehyde, with acetaldehyde being subsequently converted to acetyl-CoA." [GOC:bf, GOC:mah, MetaCyc:PWY-5436]
subset: gosubset_prok
synonym: "L-threonine breakdown to acetyl-CoA" EXACT [GOC:bf, GOC:mah]
synonym: "L-threonine catabolism to acetyl-CoA" EXACT [GOC:bf, GOC:mah]
synonym: "L-threonine degradation to acetyl-CoA" EXACT [GOC:bf, GOC:mah]
synonym: "threonine catabolic process to acetyl-CoA" BROAD [GOC:bf]
xref: MetaCyc:PWY-5436
is_a: GO:0006084 ! acetyl-CoA metabolic process
is_a: GO:0006567 ! threonine catabolic process
created_by: midori
creation_date: 2009-06-03T01:40:22Z

[Term]
id: GO:0070691
name: P-TEFb complex
namespace: cellular_component
def: "A dimeric positive transcription elongation factor complex b that comprises a cyclin-dependent kinase containing the catalytic subunit, Cdk9, and a regulatory subunit, cyclin T." [GOC:mah, GOC:vw, http://en.wikipedia.org/wiki/P-TEFb, PMID:16721054, PMID:19328067]
synonym: "Bur1/Bur2 complex" NARROW [PMID:16721054, PMID:19328067]
synonym: "dimeric positive transcription elongation factor complex b" RELATED []
synonym: "Sgv1/Bur2 complex" NARROW [GOC:mah]
is_a: GO:0008024 ! cyclin/CDK positive transcription elongation factor complex
created_by: midori
creation_date: 2009-06-03T03:12:56Z

[Term]
id: GO:0070692
name: CTDK-1 complex
namespace: cellular_component
def: "A positive transcription elongation factor complex that comprises the CDK kinase CTK1 (in budding yeast), Lsk1 (in fission yeast) (corresponding to the Panther PTHR24056:SF39 family), a cyclin and an additional gamma subunit (corresponding to the InterPRO entry IPR024638)." [GOC:mah, GOC:vw, PMID:16721054, PMID:19328067]
synonym: "C-terminal domain kinase I complex" EXACT [PMID:15047695, PMID:16721054, PMID:19328067]
synonym: "CTDK-I complex" EXACT [PMID:15047695, PMID:16721054, PMID:19328067]
synonym: "Ctk complex" EXACT [PMID:16721054]
synonym: "trimeric positive transcription elongation factor complex b" RELATED []
is_a: GO:0008024 ! cyclin/CDK positive transcription elongation factor complex
created_by: midori
creation_date: 2009-06-03T03:18:04Z

[Term]
id: GO:0070693
name: P-TEFb-cap methyltransferase complex
namespace: cellular_component
def: "A protein complex that is formed by the association of positive transcription elongation factor complex b (P-TEFb) with the mRNA capping methyltransferase." [PMID:17332744, PMID:19328067]
synonym: "Cdk9-Pcm1 complex" NARROW [GOC:vw]
synonym: "P-TEFb-Pcm1 complex" NARROW [GOC:vw]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part
created_by: midori
creation_date: 2009-06-04T02:38:58Z

[Term]
id: GO:0070694
name: deoxyribonucleoside 5'-monophosphate N-glycosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a deoxyribonucleoside 5'-monophosphate + H2O = deoxyribose 5-monophosphate + a purine or pyrimidine base." [GOC:ab, PMID:17234634]
subset: gosubset_prok
synonym: "deoxynucleoside 5'-monophosphate N-glycosidase activity" EXACT []
xref: EC:3.2.2.-
xref: IMG:03312
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds
created_by: midori
creation_date: 2009-06-04T03:06:57Z

[Term]
id: GO:0070695
name: FHF complex
namespace: cellular_component
def: "A protein complex that is composed of AKTIP/FTS, FAM160A2/p107FHIP, and one or more members of the Hook family of proteins, HOOK1, HOOK2, and HOOK3. The complex is thought to promote vesicle trafficking and/or fusion, and associates with the homotypic vesicular sorting complex (the HOPS complex)." [GOC:ab, GOC:mah, PMID:18799622]
comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part
created_by: midori
creation_date: 2009-06-04T03:17:29Z

[Term]
id: GO:0070696
name: transmembrane receptor protein serine/threonine kinase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a receptor that spans a cell membrane and possesses protein serine/threonine kinase activity." [GOC:BHF, GOC:mah]
is_a: GO:0033612 ! receptor serine/threonine kinase binding
created_by: midori
creation_date: 2009-06-04T03:57:42Z

[Term]
id: GO:0070697
name: activin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an activin receptor." [GOC:BHF, GOC:vk]
is_a: GO:0070696 ! transmembrane receptor protein serine/threonine kinase binding
created_by: midori
creation_date: 2009-06-04T04:02:13Z

[Term]
id: GO:0070698
name: type I activin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type I activin receptor." [GOC:BHF, GOC:vk]
is_a: GO:0070697 ! activin receptor binding
created_by: midori
creation_date: 2009-06-04T04:15:21Z

[Term]
id: GO:0070699
name: type II activin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type II activin receptor." [GOC:BHF, GOC:vk]
is_a: GO:0070697 ! activin receptor binding
created_by: midori
creation_date: 2009-06-04T04:16:26Z

[Term]
id: GO:0070700
name: BMP receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a BMP receptor." [GOC:BHF, GOC:vk]
synonym: "bone morphogenetic protein receptor binding" EXACT [GOC:mah]
is_a: GO:0070696 ! transmembrane receptor protein serine/threonine kinase binding
created_by: midori
creation_date: 2009-06-04T04:24:16Z

[Term]
id: GO:0070701
name: mucus layer
namespace: cellular_component
def: "An extracellular region part that consists of a protective layer of mucus secreted by epithelial cells lining tubular organs of the body such as the colon or secreted into fluids such as saliva. Mucus is a viscous slimy secretion consisting of mucins (i.e. highly glycosylated mucin proteins) and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes." [GOC:krc, GOC:mah, GOC:mm2, http://en.wikipedia.org/wiki/Mucin, PMID:18806221, PMID:19432394]
synonym: "extracellular proteinaceous gel" BROAD []
synonym: "mucous" EXACT []
synonym: "mucous layer" EXACT []
synonym: "mucus" EXACT []
is_a: GO:0044421 ! extracellular region part
created_by: midori
creation_date: 2009-06-08T02:31:34Z

[Term]
id: GO:0070702
name: inner mucus layer
namespace: cellular_component
def: "The inner of two mucus layers secreted by epithelial cells in the colon; the inner mucus layer is firmly attached to the epithelium, is densely packed with a compact stratified appearance and is devoid of bacteria." [GOC:mah, GOC:mm2, PMID:18806221, PMID:19432394]
is_a: GO:0070701 ! mucus layer
created_by: midori
creation_date: 2009-06-08T02:38:55Z

[Term]
id: GO:0070703
name: outer mucus layer
namespace: cellular_component
def: "The outer of two mucus layers secreted by epithelial cells in the colon; the outer mucus layer is loosely packed and can be colonized by bacteria." [GOC:mah, GOC:mm2, PMID:18806221, PMID:19432394]
is_a: GO:0070701 ! mucus layer
created_by: midori
creation_date: 2009-06-08T02:44:51Z

[Term]
id: GO:0070704
name: sterol desaturase activity
namespace: molecular_function
def: "Catalysis of the introduction of a double bond into a sterol molecule." [GOC:mah, GOC:vw]
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
created_by: midori
creation_date: 2009-06-08T03:53:44Z

[Term]
id: GO:0070705
name: RNA nucleotide insertion
namespace: biological_process
def: "The modification of an RNA molecule by insertion of one or more nucleotides." [GOC:cb, GOC:mah]
is_a: GO:0009451 ! RNA modification
created_by: midori
creation_date: 2009-06-08T04:48:35Z

[Term]
id: GO:0070706
name: RNA nucleotide deletion
namespace: biological_process
def: "The modification of an RNA molecule by removal of a single nucleotide." [GOC:cb, GOC:mah]
synonym: "RNA nucleotide excision" EXACT [GOC:cb, GOC:mah]
is_a: GO:0009451 ! RNA modification
created_by: midori
creation_date: 2009-06-08T04:50:51Z

[Term]
id: GO:0070707
name: RNA dinucleotide insertion
namespace: biological_process
def: "The modification of an RNA molecule by insertion of a dinucleotide." [GOC:cb, GOC:mah]
is_a: GO:0070705 ! RNA nucleotide insertion
created_by: midori
creation_date: 2009-06-08T04:50:59Z

[Term]
id: GO:0070708
name: RNA cytidine insertion
namespace: biological_process
def: "The modification of an RNA molecule by insertion of a cytidine nucleotide." [GOC:cb, GOC:mah]
synonym: "RNA C insertion" EXACT [GOC:mah]
is_a: GO:0070705 ! RNA nucleotide insertion
created_by: midori
creation_date: 2009-06-08T04:52:49Z

[Term]
id: GO:0070709
name: RNA guanosine insertion
namespace: biological_process
def: "The modification of an RNA molecule by insertion of a guanosine nucleotide." [GOC:cb, GOC:mah]
synonym: "RNA G insertion" EXACT [GOC:mah]
is_a: GO:0070705 ! RNA nucleotide insertion
created_by: midori
creation_date: 2009-06-08T04:57:26Z

[Term]
id: GO:0070710
name: RNA uridine deletion
namespace: biological_process
def: "The modification of an RNA molecule by removal of a uridine nucleotide." [GOC:cb, GOC:mah]
synonym: "RNA U deletion" EXACT [GOC:mah]
synonym: "RNA uridine excision" EXACT [GOC:cb, GOC:mah]
is_a: GO:0070706 ! RNA nucleotide deletion
created_by: midori
creation_date: 2009-06-08T05:12:43Z

[Term]
id: GO:0070711
name: RNA adenosine-uridine insertion
namespace: biological_process
def: "The modification of an RNA molecule by insertion of an adenosine-uridine dinucleotide." [GOC:cb, GOC:mah]
synonym: "RNA AU insertion" EXACT [GOC:mah]
is_a: GO:0070707 ! RNA dinucleotide insertion
created_by: midori
creation_date: 2009-06-08T05:16:39Z

[Term]
id: GO:0070712
name: RNA cytidine-uridine insertion
namespace: biological_process
def: "The modification of an RNA molecule by insertion of an cytidine-uridine dinucleotide." [GOC:cb, GOC:mah]
synonym: "RNA CU insertion" EXACT [GOC:mah]
is_a: GO:0070707 ! RNA dinucleotide insertion
created_by: midori
creation_date: 2009-06-08T05:27:01Z

[Term]
id: GO:0070713
name: RNA guanosine-cytidine insertion
namespace: biological_process
def: "The modification of an RNA molecule by insertion of an guanosine-cytidine dinucleotide." [GOC:cb, GOC:mah]
synonym: "RNA GC insertion" EXACT [GOC:mah]
is_a: GO:0070707 ! RNA dinucleotide insertion
created_by: midori
creation_date: 2009-06-08T05:31:43Z

[Term]
id: GO:0070714
name: RNA guanosine-uridine insertion
namespace: biological_process
def: "The modification of an RNA molecule by insertion of an guanosine-uridine insertion dinucleotide." [GOC:cb, GOC:mah]
synonym: "RNA GU insertion" EXACT [GOC:mah]
is_a: GO:0070707 ! RNA dinucleotide insertion
created_by: midori
creation_date: 2009-06-08T05:33:20Z

[Term]
id: GO:0070715
name: sodium-dependent organic cation transport
namespace: biological_process
def: "The directed, sodium-dependent, movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:BHF, GOC:mah]
is_a: GO:0015695 ! organic cation transport
created_by: midori
creation_date: 2009-06-09T03:26:27Z

[Term]
id: GO:0070716
name: mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication
namespace: biological_process
def: "A mismatch repair process that corrects errors introduced that ensures the accuracy of DNA replication." [GOC:BHF, GOC:mah]
subset: gosubset_prok
synonym: "mismatch repair involved in maintenance of fidelity during DNA-dependent DNA replication" RELATED [GOC:dph, GOC:tb]
is_a: GO:0006298 ! mismatch repair
intersection_of: GO:0006298 ! mismatch repair
intersection_of: part_of GO:0045005 ! DNA-dependent DNA replication maintenance of fidelity
relationship: part_of GO:0045005 ! DNA-dependent DNA replication maintenance of fidelity
created_by: midori
creation_date: 2009-06-09T04:00:29Z

[Term]
id: GO:0070717
name: poly-purine tract binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any stretch of purines (adenine or guanine) in an RNA molecule." [GOC:mah]
is_a: GO:0003727 ! single-stranded RNA binding
created_by: midori
creation_date: 2009-06-10T03:32:15Z

[Term]
id: GO:0070718
name: alphaPDGFR-SHP-2 complex
namespace: cellular_component
def: "A protein complex that contains the platelet-derived growth factor alpha receptor (alphaPDGFR; PDGFRA) and the adaptor protein SHP-2, and is involved signaling via the PDGFR signaling pathway." [GOC:mah, PMID:8943348]
synonym: "PDGFRA-SHP-2 complex, PDGF stimulated" NARROW [CORUM:3183]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-06-10T05:00:43Z

[Term]
id: GO:0070719
name: alphaPDGFR-PLC-gamma-1-PI3K-SHP-2 complex
namespace: cellular_component
def: "A protein complex that contains the platelet-derived growth factor alpha receptor (alphaPDGFR; PDGFRA), phospholipase C-gamma-1 (PLC-gamma-1), phosphatidylinositol 3-kinase (PI3K) and the adaptor protein SHP-2, and is involved signaling via the PDGFR signaling pathway." [GOC:mah, PMID:8943348]
synonym: "PDGFRA-PLC-gamma-1-PI3K-SHP-2 complex, PDGF stimulated" NARROW [CORUM:2551]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-06-10T05:04:20Z

[Term]
id: GO:0070720
name: Grb2-SHP-2 complex
namespace: cellular_component
def: "A protein complex that contains the receptor adaptor proteins Grb2 and SHP-2, and is involved signaling via the PDGFR signaling pathway." [GOC:mah, PMID:8943348]
synonym: "GRB2-SHP-2 complex, PDGF stimulated" NARROW [CORUM:3186]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-06-10T05:08:21Z

[Term]
id: GO:0070721
name: ISGF3 complex
namespace: cellular_component
def: "A transcription factor complex that consists of a Stat1-Stat2 heterodimer and the IRF9 protein." [GOC:mah, PMID:8943351]
synonym: "interferon-stimulated gene factor 3 transcription complex" EXACT [CORUM:60]
is_a: GO:0090575 ! RNA polymerase II transcription factor complex
created_by: midori
creation_date: 2009-06-10T05:22:05Z

[Term]
id: GO:0070722
name: Tle3-Aes complex
namespace: cellular_component
def: "A transcriptional repressor complex that consists of a heterodimer of the proteins Tle3 (also known as Grg3b) and Aes (Grg5), which are homologs of the Drosophila groucho gene product." [GOC:mah, PMID:8955148]
synonym: "Grg3b-Grg5 complex" EXACT [CORUM:3130, PMID:8955148]
is_a: GO:0090571 ! RNA polymerase II transcription repressor complex
created_by: midori
creation_date: 2009-06-10T05:45:28Z

[Term]
id: GO:0070723
name: response to cholesterol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus." [GOC:BHF, GOC:vk]
is_a: GO:0036314 ! response to sterol
created_by: midori
creation_date: 2009-06-15T02:28:27Z

[Term]
id: GO:0070724
name: BMP receptor complex
namespace: cellular_component
def: "A protein complex that acts as a receptor for bone morphogenetic proteins (BMPs); a homo- or heterodimer of type I and/or type II BMP receptor subunits." [GOC:mah, GOC:mh, PMID:19377468]
synonym: "bone morphogenetic protein receptor complex" EXACT [GOC:mah]
is_a: GO:0098802 ! plasma membrane receptor complex
relationship: part_of GO:0005887 ! integral component of plasma membrane
created_by: midori
creation_date: 2009-06-15T02:34:27Z

[Term]
id: GO:0070725
name: Yb body
namespace: cellular_component
def: "A cytoplasmic part that appears as an electron-dense sphere of around 1.5 micron diameter containing Yb protein found in somatic cells of ovary and testis. There are one to two Yb bodies per cell." [GOC:sart, PMID:19433453]
is_a: GO:0044424 ! intracellular part
created_by: midori
creation_date: 2009-06-15T05:17:28Z

[Term]
id: GO:0070726
name: cell wall assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a cell wall. A cell wall is a rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells." [GOC:mah]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0071555 ! cell wall organization
relationship: part_of GO:0042546 ! cell wall biogenesis
created_by: midori
creation_date: 2009-06-16T03:58:20Z

[Term]
id: GO:0070727
name: cellular macromolecule localization
namespace: biological_process
def: "Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah]
synonym: "cellular macromolecule localisation" EXACT [GOC:mah]
is_a: GO:0033036 ! macromolecule localization
is_a: GO:0051641 ! cellular localization
created_by: midori
creation_date: 2009-06-16T04:08:29Z

[Term]
id: GO:0070728
name: leucine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with 2-amino-4-methylpentanoic acid." [CHEBI:25017, GOC:BHF, GOC:mah]
synonym: "Leu binding" EXACT [GOC:mah]
is_a: GO:0016597 ! amino acid binding
is_a: GO:0043169 ! cation binding
created_by: midori
creation_date: 2009-06-17T03:16:30Z

[Term]
id: GO:0070729
name: cyclic nucleotide transport
namespace: biological_process
def: "The directed movement of a cyclic nucleotide, any nucleotide in which phosphate group is in diester linkage to two positions on the sugar residue, into, out of or within a cell." [GOC:mah, ISBN:0198506732]
is_a: GO:0006862 ! nucleotide transport
created_by: midori
creation_date: 2009-06-17T03:49:56Z

[Term]
id: GO:0070730
name: cAMP transport
namespace: biological_process
def: "The directed movement of cyclic AMP (cAMP), into, out of or within a cell." [GOC:mah, ISBN:0198506732]
synonym: "cyclic AMP transport" EXACT [GOC:mah]
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015868 ! purine ribonucleotide transport
is_a: GO:0051503 ! adenine nucleotide transport
is_a: GO:0070729 ! cyclic nucleotide transport
created_by: midori
creation_date: 2009-06-17T03:53:45Z

[Term]
id: GO:0070731
name: cGMP transport
namespace: biological_process
def: "The directed movement of cyclic GMP (cGMP), into, out of or within a cell." [GOC:mah, ISBN:0198506732]
synonym: "cyclic GMP transport" EXACT [GOC:mah]
is_a: GO:0001408 ! guanine nucleotide transport
is_a: GO:0015711 ! organic anion transport
is_a: GO:0070729 ! cyclic nucleotide transport
created_by: midori
creation_date: 2009-06-17T04:40:27Z

[Term]
id: GO:0070732
name: spindle envelope
namespace: cellular_component
def: "An organelle envelope that surrounds the chromosomes and the central part of the spindle apparatus during mitosis and meiosis; observed in many invertebrates. The spindle envelope consists of membrane layers, called parafusorial membranes, derived from endoplasmic reticulum membrane; in male meiosis it forms during prometaphase and persists until early in the ensuing interphase." [GOC:mah, GOC:sart, PMID:19417004, PMID:6428889]
subset: goslim_candida
is_a: GO:0031967 ! organelle envelope
created_by: midori
creation_date: 2009-06-18T12:00:59Z

[Term]
id: GO:0070733
name: protein adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + protein = diphosphate + adenylyl-protein; mediates the addition of an adenylyl (adenosine 5'-monophosphate; AMP group) to specific residues of target proteins." [GOC:mah, PMID:19039103, PMID:19362538]
subset: gosubset_prok
synonym: "adenosine monophosphate-protein transferase activity" EXACT [GOC:mah]
synonym: "AMPylator" RELATED [GOC:mah]
is_a: GO:0070566 ! adenylyltransferase activity
relationship: part_of GO:0018117 ! protein adenylylation
created_by: midori
creation_date: 2009-06-18T01:09:15Z

[Term]
id: GO:0070734
name: histone H3-K27 methylation
namespace: biological_process
def: "The modification of histone H3 by addition of one or more methyl groups to lysine at position 27 of the histone." [GOC:mah, GOC:pr]
synonym: "histone H3 K27 methylation" EXACT [GOC:mah]
synonym: "histone H3K27me" EXACT [GOC:mah]
synonym: "histone lysine H3 K27 methylation" EXACT [GOC:mah]
is_a: GO:0034968 ! histone lysine methylation
created_by: midori
creation_date: 2009-06-19T11:44:37Z

[Term]
id: GO:0070735
name: protein-glycine ligase activity
namespace: molecular_function
def: "Catalysis of the posttranslational transfer of one or more glycine residues to a specific glutamate residue on a target protein." [GOC:mah, PMID:19524510]
synonym: "protein glycylase activity" EXACT [GOC:mah]
xref: EC:6.3.2.-
is_a: GO:0016881 ! acid-amino acid ligase activity
created_by: midori
creation_date: 2009-06-19T01:51:21Z

[Term]
id: GO:0070736
name: protein-glycine ligase activity, initiating
namespace: molecular_function
def: "Catalysis of the posttranslational transfer of a glycine residue to the gamma-carboxyl group(s) of one or more specific glutamate residues on a target protein." [GOC:mah, PMID:19524510]
synonym: "protein glycylase activity, initiating" EXACT [GOC:mah]
xref: EC:6.3.2.-
is_a: GO:0070735 ! protein-glycine ligase activity
created_by: midori
creation_date: 2009-06-19T01:56:32Z

[Term]
id: GO:0070737
name: protein-glycine ligase activity, elongating
namespace: molecular_function
def: "Catalysis of the posttranslational transfer of one or more glycine residues to a glycine residue covalently attached to the gamma-carboxyl group of a glutamate residue on a target protein, resulting in the elongation of a polyglycine side chain." [GOC:mah, PMID:19524510]
synonym: "protein glycylase activity, elongating" EXACT [GOC:mah]
xref: EC:6.3.2.-
is_a: GO:0070735 ! protein-glycine ligase activity
created_by: midori
creation_date: 2009-06-19T02:00:21Z

[Term]
id: GO:0070738
name: tubulin-glycine ligase activity
namespace: molecular_function
def: "Catalysis of the posttranslational transfer of one or more glycine residues to a specific glutamate residue on a target tubulin molecule; acts on alpha or beta tubulin." [GOC:mah, PMID:19524510]
synonym: "tubulin glycylase activity" EXACT [GOC:mah]
xref: EC:6.3.2.-
is_a: GO:0070735 ! protein-glycine ligase activity
created_by: midori
creation_date: 2009-06-19T02:02:01Z

[Term]
id: GO:0070739
name: protein-glutamic acid ligase activity
namespace: molecular_function
def: "Catalysis of the posttranslational transfer of one or more glutamate residues to a specific residue on a target protein." [GOC:mah, PMID:19524510]
synonym: "protein glutamylase activity" EXACT [GOC:mah]
synonym: "protein-glutamate ligase activity" EXACT [GOC:mah]
xref: EC:6.3.2.-
is_a: GO:0016881 ! acid-amino acid ligase activity
created_by: midori
creation_date: 2009-06-19T02:23:22Z

[Term]
id: GO:0070740
name: tubulin-glutamic acid ligase activity
namespace: molecular_function
def: "Catalysis of the posttranslational transfer of one or more glutamate residues to the gamma-carboxyl group(s) of one or more specific glutamate residues on a tubulin molecule." [GOC:mah, PMID:19524510]
synonym: "tubulin glutamylase activity" EXACT [GOC:mah]
synonym: "tubulin-glutamate ligase activity" EXACT [GOC:mah]
xref: EC:6.3.2.-
is_a: GO:0070739 ! protein-glutamic acid ligase activity
created_by: midori
creation_date: 2009-06-19T02:26:15Z

[Term]
id: GO:0070741
name: response to interleukin-6
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus." [GOC:mah]
synonym: "response to IL-6" EXACT [GOC:mah]
is_a: GO:0034097 ! response to cytokine
created_by: midori
creation_date: 2009-06-19T03:39:12Z

[Term]
id: GO:0070742
name: C2H2 zinc finger domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a C2H2-type zinc finger domain of a protein. The C2H2 zinc finger is the classical zinc finger domain, in which two conserved cysteines and histidines co-ordinate a zinc ion." [GOC:BHF, GOC:mah, Pfam:PF00096]
is_a: GO:0019904 ! protein domain specific binding
created_by: midori
creation_date: 2009-06-23T11:26:02Z

[Term]
id: GO:0070743
name: interleukin-23 complex
namespace: cellular_component
def: "A protein complex that is composed of an interleukin-23 alpha (p19, product of the IL23A gene) and an interleukin-12 beta (p40, product of the IL12B gene) subunit and is secreted into the extracellular space." [GOC:add, PMID:11114383, PMID:15999093]
comment: Note that this heterodimeric cytokine utilizes the same beta subunit as IL-12.
synonym: "IL-23 complex" EXACT [GOC:add]
synonym: "IL12B" NARROW [GOC:add]
synonym: "IL23A" NARROW [GOC:add]
synonym: "p19" NARROW [GOC:add]
synonym: "p40" NARROW [GOC:add]
is_a: GO:0043234 ! protein complex
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005615 ! extracellular space
created_by: midori
creation_date: 2009-06-23T01:06:02Z

[Term]
id: GO:0070744
name: interleukin-27 complex
namespace: cellular_component
def: "A protein complex that is composed of an interleukin-27p28 subunit (product of the IL27 gene) and an EBI3 subunit and is secreted into the extracellular space." [GOC:add, PMID:15999093, PMID:19161428]
comment: Note that this heterodimeric cytokine utilizes the same EBI3 subunit (product of EBI3, Epstein-Barr virus induced gene 3) as its beta chain as IL-35 uses for its beta chain. Also note that the product of the IL27 gene is the alpha subunit of IL-27. The functional IL-27 protein complex requires both subunits.
synonym: "EBI3" NARROW [GOC:add]
synonym: "IL-27 complex" EXACT [GOC:add]
synonym: "IL27" NARROW [GOC:add]
synonym: "p28" NARROW [GOC:add]
is_a: GO:0043234 ! protein complex
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005615 ! extracellular space
created_by: midori
creation_date: 2009-06-23T01:09:58Z

[Term]
id: GO:0070745
name: interleukin-35 complex
namespace: cellular_component
def: "A protein complex that is composed of an interleukin-12 alpha subunit (p35, product of the IL12A gene) and an EBI3 subunit and is secreted into the extracellular space." [GOC:add, PMID:19161428, PMID:19161429]
comment: Note that this heterodimeric cytokine utilizes the same IL-12p35 subunit as its alpha chain as IL-12 uses and the same EBI3 subunit (product of EBI3, Epstein-Barr virus induced gene 3) as its beta chain as IL-27 uses. IL-35 requires both subunits -- there is no separate IL35 gene.
synonym: "EBI3" NARROW [GOC:add]
synonym: "IL-35 complex" EXACT [GOC:add]
synonym: "IL12A" NARROW [GOC:add]
synonym: "p35" NARROW [GOC:add]
is_a: GO:0043234 ! protein complex
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005615 ! extracellular space
created_by: midori
creation_date: 2009-06-23T01:13:14Z

[Term]
id: GO:0070746
name: interleukin-35 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-35." [GOC:add]
synonym: "IL-35 binding" EXACT [GOC:add]
is_a: GO:0019955 ! cytokine binding
created_by: midori
creation_date: 2009-06-23T01:15:36Z

[Term]
id: GO:0070747
name: interleukin-35 receptor activity
namespace: molecular_function
def: "Combining with interleukin-35 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling]
synonym: "IL-35 receptor activity" EXACT [GOC:add]
synonym: "IL-35R" EXACT [GOC:add]
is_a: GO:0004896 ! cytokine receptor activity
relationship: has_part GO:0070746 ! interleukin-35 binding
relationship: part_of GO:0070757 ! interleukin-35-mediated signaling pathway
created_by: midori
creation_date: 2009-06-23T01:18:09Z

[Term]
id: GO:0070748
name: interleukin-35 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-35 receptor." [GOC:add]
synonym: "IL-35" NARROW [GOC:add]
synonym: "interleukin-35 receptor ligand" NARROW [GOC:add]
is_a: GO:0005126 ! cytokine receptor binding
created_by: midori
creation_date: 2009-06-23T01:21:54Z

[Term]
id: GO:0070749
name: interleukin-35 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-35." [GOC:add]
synonym: "IL-35 biosynthesis" EXACT [GOC:mah]
synonym: "IL-35 biosynthetic process" EXACT [GOC:add]
synonym: "interleukin-35 anabolism" EXACT [GOC:mah]
synonym: "interleukin-35 biosynthesis" EXACT [GOC:mah]
synonym: "interleukin-35 formation" EXACT [GOC:mah]
synonym: "interleukin-35 synthesis" EXACT [GOC:mah]
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0070753 ! interleukin-35 production
created_by: midori
creation_date: 2009-06-23T01:25:11Z

[Term]
id: GO:0070750
name: regulation of interleukin-35 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-35." [GOC:add]
synonym: "regulation of IL-35 biosynthesis" EXACT [GOC:mah]
synonym: "regulation of IL-35 biosynthetic process" EXACT [GOC:add]
synonym: "regulation of interleukin-35 anabolism" EXACT [GOC:mah]
synonym: "regulation of interleukin-35 biosynthesis" EXACT [GOC:mah]
synonym: "regulation of interleukin-35 formation" EXACT [GOC:mah]
synonym: "regulation of interleukin-35 synthesis" EXACT [GOC:mah]
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
is_a: GO:0070754 ! regulation of interleukin-35 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070749 ! interleukin-35 biosynthetic process
relationship: regulates GO:0070749 ! interleukin-35 biosynthetic process
created_by: midori
creation_date: 2009-06-23T01:29:17Z

[Term]
id: GO:0070751
name: negative regulation of interleukin-35 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-35." [GOC:add]
synonym: "down regulation of interleukin-35 biosynthetic process" EXACT [GOC:mah]
synonym: "down-regulation of interleukin-35 biosynthetic process" EXACT [GOC:mah]
synonym: "downregulation of interleukin-35 biosynthetic process" EXACT [GOC:mah]
synonym: "inhibition of interleukin-35 biosynthetic process" NARROW [GOC:mah]
synonym: "negative regulation of IL-35 biosynthesis" EXACT [GOC:mah]
synonym: "negative regulation of IL-35 biosynthetic process" EXACT [GOC:add]
synonym: "negative regulation of interleukin-35 anabolism" EXACT [GOC:mah]
synonym: "negative regulation of interleukin-35 biosynthesis" EXACT [GOC:mah]
synonym: "negative regulation of interleukin-35 formation" EXACT [GOC:mah]
synonym: "negative regulation of interleukin-35 synthesis" EXACT [GOC:mah]
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0070750 ! regulation of interleukin-35 biosynthetic process
is_a: GO:0070755 ! negative regulation of interleukin-35 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070749 ! interleukin-35 biosynthetic process
relationship: negatively_regulates GO:0070749 ! interleukin-35 biosynthetic process
created_by: midori
creation_date: 2009-06-23T01:34:54Z

[Term]
id: GO:0070752
name: positive regulation of interleukin-35 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-35." [GOC:add]
synonym: "activation of interleukin-35 biosynthetic process" NARROW [GOC:mah]
synonym: "positive regulation of IL-35 biosynthesis" EXACT [GOC:mah]
synonym: "positive regulation of IL-35 biosynthetic process" EXACT [GOC:add]
synonym: "positive regulation of interleukin-35 anabolism" EXACT [GOC:mah]
synonym: "positive regulation of interleukin-35 biosynthesis" EXACT [GOC:mah]
synonym: "positive regulation of interleukin-35 formation" EXACT [GOC:mah]
synonym: "positive regulation of interleukin-35 synthesis" EXACT [GOC:mah]
synonym: "stimulation of interleukin-35 biosynthetic process" NARROW [GOC:mah]
synonym: "up regulation of interleukin-35 biosynthetic process" EXACT [GOC:mah]
synonym: "up-regulation of interleukin-35 biosynthetic process" EXACT [GOC:mah]
synonym: "upregulation of interleukin-35 biosynthetic process" EXACT [GOC:mah]
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0070750 ! regulation of interleukin-35 biosynthetic process
is_a: GO:0070756 ! positive regulation of interleukin-35 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070749 ! interleukin-35 biosynthetic process
relationship: positively_regulates GO:0070749 ! interleukin-35 biosynthetic process
created_by: midori
creation_date: 2009-06-23T01:39:45Z

[Term]
id: GO:0070753
name: interleukin-35 production
namespace: biological_process
def: "The appearance of interleukin-35 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-35 production" EXACT [GOC:add]
is_a: GO:0001816 ! cytokine production
created_by: midori
creation_date: 2009-06-23T01:42:04Z

[Term]
id: GO:0070754
name: regulation of interleukin-35 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-35 production." [GOC:mah]
synonym: "regulation of IL-35 production" EXACT [GOC:add]
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070753 ! interleukin-35 production
relationship: regulates GO:0070753 ! interleukin-35 production
created_by: midori
creation_date: 2009-06-23T01:44:37Z

[Term]
id: GO:0070755
name: negative regulation of interleukin-35 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-35 production." [GOC:mah]
synonym: "down regulation of interleukin-35 production" EXACT [GOC:mah]
synonym: "down-regulation of interleukin-35 production" EXACT [GOC:mah]
synonym: "downregulation of interleukin-35 production" EXACT [GOC:mah]
synonym: "inhibition of interleukin-35 production" NARROW [GOC:mah]
synonym: "negative regulation of IL-35 production" EXACT [GOC:add]
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0070754 ! regulation of interleukin-35 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070753 ! interleukin-35 production
relationship: negatively_regulates GO:0070753 ! interleukin-35 production
created_by: midori
creation_date: 2009-06-23T01:48:25Z

[Term]
id: GO:0070756
name: positive regulation of interleukin-35 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-35 production." [GOC:mah]
synonym: "activation of interleukin-35 production" NARROW [GOC:mah]
synonym: "positive regulation of IL-35 production" EXACT [GOC:add]
synonym: "stimulation of interleukin-35 production" NARROW [GOC:mah]
synonym: "up regulation of interleukin-35 production" EXACT [GOC:mah]
synonym: "up-regulation of interleukin-35 production" EXACT [GOC:mah]
synonym: "upregulation of interleukin-35 production" EXACT [GOC:mah]
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0070754 ! regulation of interleukin-35 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070753 ! interleukin-35 production
relationship: positively_regulates GO:0070753 ! interleukin-35 production
created_by: midori
creation_date: 2009-06-23T01:52:31Z

[Term]
id: GO:0070757
name: interleukin-35-mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of interleukin-35 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:add, GOC:mah, GOC:signaling]
synonym: "IL-35-mediated signaling pathway" EXACT [GOC:add]
synonym: "interleukin-35-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0019221 ! cytokine-mediated signaling pathway
created_by: midori
creation_date: 2009-06-23T01:55:02Z

[Term]
id: GO:0070758
name: regulation of interleukin-35-mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-35-mediated binding to a cell surface receptor." [GOC:mah]
synonym: "regulation of IL-35-mediated signaling pathway" EXACT [GOC:mah]
synonym: "regulation of interleukin-35-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070757 ! interleukin-35-mediated signaling pathway
relationship: regulates GO:0070757 ! interleukin-35-mediated signaling pathway
created_by: midori
creation_date: 2009-06-23T01:58:43Z

[Term]
id: GO:0070759
name: negative regulation of interleukin-35-mediated signaling pathway
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-35 binding to a cell surface receptor." [GOC:mah]
synonym: "negative regulation of IL-35-mediated signaling pathway" EXACT [GOC:add]
synonym: "negative regulation of interleukin-35-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway
is_a: GO:0070758 ! regulation of interleukin-35-mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070757 ! interleukin-35-mediated signaling pathway
relationship: negatively_regulates GO:0070757 ! interleukin-35-mediated signaling pathway
created_by: midori
creation_date: 2009-06-23T02:02:07Z

[Term]
id: GO:0070760
name: positive regulation of interleukin-35-mediated signaling pathway
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-35 binding to a cell surface receptor." [GOC:mah]
synonym: "positive regulation of IL-35-mediated signaling pathway" EXACT [GOC:add]
synonym: "positive regulation of interleukin-35-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway
is_a: GO:0070758 ! regulation of interleukin-35-mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070757 ! interleukin-35-mediated signaling pathway
relationship: positively_regulates GO:0070757 ! interleukin-35-mediated signaling pathway
created_by: midori
creation_date: 2009-06-23T02:06:16Z

[Term]
id: GO:0070761
name: pre-snoRNP complex
namespace: cellular_component
def: "A ribonucleoprotein complex that contains a precursor small nucleolar RNA (pre-snoRNA) and associated proteins, and forms during small nucleolar ribonucleoprotein complex (snoRNP) assembly. Pre-snoRNP complexes may contain proteins not found in the corresponding mature snoRNP complexes." [GOC:BHF, GOC:mah, GOC:rl, PMID:17636026, PMID:17709390]
synonym: "pre-small nucleolar ribonucleoprotein complex" EXACT [GOC:rl]
is_a: GO:0030529 ! intracellular ribonucleoprotein complex
created_by: midori
creation_date: 2009-06-23T02:32:10Z

[Term]
id: GO:0070762
name: nuclear pore transmembrane ring
namespace: cellular_component
def: "A subcomplex of the nuclear pore complex (NPC) that spans the nuclear membrane and anchors the NPC to the nuclear envelope. In S. cerevisiae, the transmembrane ring is composed of Pom152p, Pom34p, and Ndc1p. In vertebrates, it is composed of Gp210, Ndc1, and Pom121. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometime referred to as the Ndc1 complex." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]
synonym: "NDC1 complex" EXACT []
synonym: "NDC1 subcomplex" EXACT [PMID:19414609]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0005643 ! nuclear pore
created_by: midori
creation_date: 2009-06-29T11:02:56Z

[Term]
id: GO:0070763
name: Delta1 complex
namespace: cellular_component
def: "A protein complex that consists of homodimer of the Notch ligand Delta1." [PMID:12794186]
synonym: "Delta1 homodimer complex" EXACT [CORUM:3271]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-06-29T01:04:12Z

[Term]
id: GO:0070764
name: gamma-secretase-Delta1 complex
namespace: cellular_component
def: "A protein complex that is formed by the association of the Notch ligand Delta1 with the gamma-secretase complex." [PMID:12794186]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-06-29T01:11:51Z

[Term]
id: GO:0070765
name: gamma-secretase complex
namespace: cellular_component
def: "A protein complex that has aspartic-type endopeptidase activity, and contains a catalytic subunit, presenilin (PS), that is a prototypical member of the GxGD-type aspartyl peptidases. The complex also contains additional subunits, including nicastrin, APH-1, PEN-2, and a regulatory subunit, CD147. Gamma-secretase cleaves several transmembrane proteins including the cell surface receptor Notch and the beta-amyloid precursor protein." [GOC:mah, PMID:15286082, PMID:15890777, PMID:17047368]
synonym: "CD147-gamma-secretase complex (APH-1a, PS-1, PEN-2, NCT variant)" NARROW [CORUM:142]
synonym: "gamma-secretase complex (APH1A, PSEN1, PSENEN, NCSTN variant)" NARROW [CORUM:130, CORUM:2891, CORUM:43, CORUM:45, CORUM:466]
synonym: "gamma-secretase complex (APH1A, PSEN2, PSENEN, NCSTN)" NARROW [CORUM:468]
synonym: "gamma-secretase complex (APH1B, PSEN1, PSENEN, NCSTN)" RELATED [CORUM:3128]
synonym: "gamma-secretase complex (APH1B, PSEN2, PSENEN, NCSTN)" NARROW [CORUM:467]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-06-29T01:33:19Z

[Term]
id: GO:0070766
name: endobrevin-synaptobrevin 2-alpha-SNAP-NSF-syntaxin-4 complex
namespace: cellular_component
def: "A SNARE complex that contains endobrevin (VAMP8), synaptobrevin 2 (VAMP2), alpha-SNAP, NSF, and syntaxin 4 (or orthologs thereof)." [PMID:8973549]
synonym: "SNARE complex (Stx4, Napa, Vamp3, Nsf, Vamp2)" NARROW [CORUM:1876]
synonym: "Stx4-Napa-Vamp3-Nsf-Vamp2 complex" NARROW [CORUM:1876]
is_a: GO:0031201 ! SNARE complex
created_by: midori
creation_date: 2009-06-29T04:41:55Z

[Term]
id: GO:0070767
name: BRCA1-Rad51 complex
namespace: cellular_component
def: "A protein complex that contains BRCA1 and Rad 51, and is involved in the control of recombination and of genome integrity." [GOC:mah, PMID:9008167]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part
created_by: midori
creation_date: 2009-06-29T05:04:21Z

[Term]
id: GO:0070768
name: synaptotagmin-synaptobrevin 2-SNAP-25-syntaxin-1a-syntaxin-1b-Unc13 complex
namespace: cellular_component
def: "A SNARE complex that contains synaptotagmin, synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, syntaxin1b, and Unc13b (or orthologs thereof)." [PMID:8999968]
synonym: "Snap25-Syt1-Unc13b-Vamp2-Stx1b2-Stx1a complex" NARROW [CORUM:1873]
synonym: "SNARE complex (Snap25, Syt1, Unc13b, Vamp2, Stx1b2, Stx1a)" NARROW [CORUM:1873]
is_a: GO:0031201 ! SNARE complex
created_by: midori
creation_date: 2009-06-29T05:14:04Z

[Term]
id: GO:0070769
name: alphaIIb-beta3 integrin-CIB complex
namespace: cellular_component
def: "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to CIB, a protein that binds calcium as well as the alphaIIb-beta3 integrin." [PMID:9030514]
synonym: "ITGA2B-ITGB3-CIB1 complex" NARROW [CORUM:2379]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-06-29T05:20:01Z

[Term]
id: GO:0070770
name: alphaIIb-beta3 integrin-CD47-FAK complex
namespace: cellular_component
def: "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface antigen CD47 and the kinase FAK." [PMID:9169439]
synonym: "ITGA2b-ITGB3-CD47-FAK complex" NARROW [CORUM:2896]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-06-29T05:43:59Z

[Term]
id: GO:0070771
name: alphaIIb-beta3 integrin-CD47-Src complex
namespace: cellular_component
def: "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface antigen CD47 and the kinase c-Src." [PMID:9169439]
synonym: "ITGA2b-ITGB3-CD47-SRC complex" NARROW [CORUM:2377]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-06-29T05:46:53Z

[Term]
id: GO:0070772
name: PAS complex
namespace: cellular_component
def: "A class III phosphatidylinositol 3-kinase complex that contains a phosphatidylinositol-3-phosphate 5-kinase subunit (Fab1p in yeast; PIKfyve in mammals), a kinase activator, and a phosphatase, and may also contain additional proteins; it is involved in regulating the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate. In mammals the complex is composed of PIKFYVE, FIG4 and VAC14. In yeast it is composed of Atg18p, Fig4p, Fab1p, Vac14p and Vac7p." [PMID:18950639, PMID:19037259, PMID:19158662]
synonym: "autophagy-specific phosphatidylinositol 3-kinase complex" RELATED [PMID:24165940]
is_a: GO:0035032 ! phosphatidylinositol 3-kinase complex, class III
is_a: GO:0044437 ! vacuolar part
relationship: part_of GO:0005774 ! vacuolar membrane
created_by: midori
creation_date: 2009-06-30T11:13:32Z

[Term]
id: GO:0070773
name: protein-N-terminal glutamine amidohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein-N-terminal-L-glutamine + H2O = protein-N-terminal-L-glutamate + NH3. This reaction is the deamidation of an N-terminal glutamine residue of a protein." [PMID:19560421]
subset: mf_needs_review
synonym: "NtQ-amidase activity" EXACT [PMID:19560421]
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
created_by: midori
creation_date: 2009-06-30T11:34:08Z

[Term]
id: GO:0070774
name: phytoceramidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a phytoceramide + H2O = a fatty acid + phytosphingosine." [GOC:pde, PMID:11356846]
xref: KEGG:R06528
xref: MetaCyc:CERAMIDASE-YEAST-RXN
xref: Reactome:REACT_101236 "phytoceramide + H2O => stearate + phytosphingosine, Sus scrofa"
xref: Reactome:REACT_101307 "phytoceramide + H2O => stearate + phytosphingosine, Xenopus tropicalis"
xref: Reactome:REACT_102955 "phytoceramide + H2O => stearate + phytosphingosine, Danio rerio"
xref: Reactome:REACT_105460 "phytoceramide + H2O => stearate + phytosphingosine, Arabidopsis thaliana"
xref: Reactome:REACT_106799 "phytoceramide + H2O => stearate + phytosphingosine, Oryza sativa"
xref: Reactome:REACT_116153 "phytoceramide + H2O => stearate + phytosphingosine, Gallus gallus"
xref: Reactome:REACT_19134 "phytoceramide + H2O => stearate + phytosphingosine, Homo sapiens"
xref: Reactome:REACT_29800 "phytoceramide + H2O => stearate + phytosphingosine, Dictyostelium discoideum"
xref: Reactome:REACT_30950 "phytoceramide + H2O => stearate + phytosphingosine, Taeniopygia guttata"
xref: Reactome:REACT_79708 "phytoceramide + H2O => stearate + phytosphingosine, Gallus gallus"
xref: Reactome:REACT_83311 "phytoceramide + H2O => stearate + phytosphingosine, Saccharomyces cerevisiae"
xref: Reactome:REACT_84754 "phytoceramide + H2O => stearate + phytosphingosine, Rattus norvegicus"
xref: Reactome:REACT_85949 "phytoceramide + H2O => stearate + phytosphingosine, Canis familiaris"
xref: Reactome:REACT_87993 "phytoceramide + H2O => stearate + phytosphingosine, Mus musculus"
xref: Reactome:REACT_93288 "phytoceramide + H2O => stearate + phytosphingosine, Bos taurus"
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds
is_a: GO:0017040 ! ceramidase activity
created_by: midori
creation_date: 2009-07-02T10:52:42Z

[Term]
id: GO:0070775
name: H3 histone acetyltransferase complex
namespace: cellular_component
def: "A multisubunit complex that catalyzes the acetylation of histone H3." [GOC:mah]
synonym: "H3 HAT complex" EXACT [GOC:mah]
is_a: GO:0000123 ! histone acetyltransferase complex
created_by: midori
creation_date: 2009-07-02T11:56:48Z

[Term]
id: GO:0070776
name: MOZ/MORF histone acetyltransferase complex
namespace: cellular_component
def: "A histone acetyltransferase complex that has histone H3 acetyltransferase and coactivator activities. Subunits of the human complex include MYST3/MOZ, MYST4/MORF, ING5, EAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3." [PMID:18794358]
is_a: GO:0070775 ! H3 histone acetyltransferase complex
created_by: midori
creation_date: 2009-07-02T12:06:04Z

[Term]
id: GO:0070777
name: D-aspartate transport
namespace: biological_process
def: "The directed movement of D-aspartate, the D-enantiomer of the anion of (2R)-2-aminobutanedioic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:17364, GOC:mah, GOC:rph]
is_a: GO:0015810 ! aspartate transport
is_a: GO:0042940 ! D-amino acid transport
created_by: midori
creation_date: 2009-07-02T01:42:57Z

[Term]
id: GO:0070778
name: L-aspartate transport
namespace: biological_process
def: "The directed movement of L-aspartate, the L-enantiomer of the anion of (2R)-2-aminobutanedioic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:17053, GOC:mah]
is_a: GO:0015807 ! L-amino acid transport
is_a: GO:0015810 ! aspartate transport
created_by: midori
creation_date: 2009-07-02T01:46:31Z

[Term]
id: GO:0070779
name: D-aspartate import
namespace: biological_process
def: "The directed movement of D-aspartate, the L-enantiomer of the anion of 2-aminopentanedioic acid, into a cell or organelle." [GOC:rph]
subset: gosubset_prok
synonym: "D-aspartate uptake" EXACT [GOC:mah]
is_a: GO:0043090 ! amino acid import
is_a: GO:0070777 ! D-aspartate transport
created_by: midori
creation_date: 2009-07-02T01:57:00Z

[Term]
id: GO:0070780
name: dihydrosphingosine-1-phosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: dihydrosphingosine 1-phosphate + H2O = dihydrosphingosine + phosphate." [GOC:pde, PMID:12815058]
synonym: "dihydrosphingosine-1-phosphate phosphohydrolase activity" EXACT [GOC:mah]
synonym: "sphinganine-1-phosphate phosphatase activity" EXACT [GOC:mah]
xref: MetaCyc:RXN3DJ-25
xref: Reactome:REACT_102737 "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate, Taeniopygia guttata"
xref: Reactome:REACT_107166 "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate, Bos taurus"
xref: Reactome:REACT_113400 "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate, Schizosaccharomyces pombe"
xref: Reactome:REACT_114387 "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate, Saccharomyces cerevisiae"
xref: Reactome:REACT_19369 "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate, Homo sapiens"
xref: Reactome:REACT_31859 "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate, Rattus norvegicus"
xref: Reactome:REACT_33754 "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate, Sus scrofa"
xref: Reactome:REACT_77400 "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate, Gallus gallus"
xref: Reactome:REACT_77802 "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate, Oryza sativa"
xref: Reactome:REACT_80240 "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate, Xenopus tropicalis"
xref: Reactome:REACT_80503 "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate, Mus musculus"
xref: Reactome:REACT_83484 "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate, Arabidopsis thaliana"
xref: Reactome:REACT_87370 "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate, Dictyostelium discoideum"
xref: Reactome:REACT_88444 "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate, Danio rerio"
xref: Reactome:REACT_93721 "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate, Canis familiaris"
is_a: GO:0016791 ! phosphatase activity
created_by: midori
creation_date: 2009-07-02T02:13:49Z

[Term]
id: GO:0070781
name: response to biotin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotin stimulus." [GOC:sl]
synonym: "response to Bios IIB" EXACT [GOC:sl]
synonym: "response to coenzyme R" EXACT [GOC:sl]
synonym: "response to vitamin B7" EXACT [GOC:sl]
synonym: "response to vitamin H" EXACT [GOC:sl]
is_a: GO:0001101 ! response to acid chemical
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033273 ! response to vitamin
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: midori
creation_date: 2009-07-02T02:34:43Z

[Term]
id: GO:0070782
name: phosphatidylserine exposure on apoptotic cell surface
namespace: biological_process
def: "A phospholipid scrambling process that results in the appearance of phosphatidylserine on the outer leaflet of the plasma membrane of an apoptotic cell, which acts as an 'eat-me' signal for engulfing cells. Phosphatidylserine is exposed on the apoptotic cell surface by a phospholipid scramblase activity." [GOC:mah, GOC:mtg_apoptosis, GOC:rk, PMID:11536005]
comment: In normal cells, phosphatidylserine residues are found exclusively on the inner side of the cellular membrane. During apoptosis, phosphatidylserine is transported to the outer cell surface by scramblase proteins. This event acts as an "eat-me" signal for macrophages to dispose of the dying cell. When annotating to this term, curators should be aware of the following: 1) phosphatidylserine exposure on the cell surface can occur in circumstances other than apoptosis (for example, when blood platelets are activated, they expose phosphatidylserine to trigger the clotting system, see PMID:21107324). Do not annotate to GO:0070782 unless phosphatidylserine exposure is shown to be part of an apoptotic event. 2) Caution should be applied when a study quotes annexin V assays. The annexin A5 protein binds to phosphatidylserine-containing membrane surfaces, which are usually only present on the inner leaflet of the membrane. However, in cells undergoing apoptosis, phosphatidylserine becomes exposed on the outer leaflet of the membrane. A positive annexin assay can therefore be linked to apoptotic death, but it shouldn't be confused with molecular events strictly involved in the process of phosphatidylserine exposure.
synonym: "externalization of phosphatidylserine" EXACT [GOC:rk]
is_a: GO:0017121 ! phospholipid scrambling
relationship: has_part GO:0017128 ! phospholipid scramblase activity
relationship: part_of GO:0097194 ! execution phase of apoptosis
created_by: midori
creation_date: 2009-07-02T02:41:44Z

[Term]
id: GO:0070783
name: growth of unicellular organism as a thread of attached cells
namespace: biological_process
def: "A filamentous growth process in which cells remain attached after division and form thread-like filaments that may penetrate into a solid growth medium such as an agar plate, exhibited by unicellular fungi under certain growth conditions." [GOC:mah, GOC:mcc]
subset: goslim_candida
is_a: GO:0044182 ! filamentous growth of a population of unicellular organisms
created_by: midori
creation_date: 2009-07-07T02:21:14Z

[Term]
id: GO:0070784
name: regulation of growth of unicellular organism as a thread of attached cells
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the process in which cells remain attached after division and form thread-like filaments that may penetrate into a solid growth medium." [GOC:mah]
is_a: GO:1900428 ! regulation of filamentous growth of a population of unicellular organisms
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070783 ! growth of unicellular organism as a thread of attached cells
relationship: regulates GO:0070783 ! growth of unicellular organism as a thread of attached cells
created_by: midori
creation_date: 2009-07-07T02:34:59Z

[Term]
id: GO:0070785
name: negative regulation of growth of unicellular organism as a thread of attached cells
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the process in which cells remain attached after division and form thread-like filaments that may penetrate into a solid growth medium." [GOC:mah]
is_a: GO:0070784 ! regulation of growth of unicellular organism as a thread of attached cells
is_a: GO:1900429 ! negative regulation of filamentous growth of a population of unicellular organisms
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070783 ! growth of unicellular organism as a thread of attached cells
relationship: negatively_regulates GO:0070783 ! growth of unicellular organism as a thread of attached cells
created_by: midori
creation_date: 2009-07-07T02:37:21Z

[Term]
id: GO:0070786
name: positive regulation of growth of unicellular organism as a thread of attached cells
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the process in which cells remain attached after division and form thread-like filaments that may penetrate into a solid growth medium." [GOC:mah]
is_a: GO:0070784 ! regulation of growth of unicellular organism as a thread of attached cells
is_a: GO:1900430 ! positive regulation of filamentous growth of a population of unicellular organisms
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070783 ! growth of unicellular organism as a thread of attached cells
relationship: positively_regulates GO:0070783 ! growth of unicellular organism as a thread of attached cells
created_by: midori
creation_date: 2009-07-07T02:39:48Z

[Term]
id: GO:0070787
name: conidiophore development
namespace: biological_process
def: "The process whose specific outcome is the progression of the conidiophore over time, from its formation to the mature structure. The conidiophore is a specialized hypha that extends aerially from the growth substrate and bears conidia, or asexual spores." [PMID:9529886]
is_a: GO:0075259 ! spore-bearing organ development
created_by: midori
creation_date: 2009-07-08T01:30:36Z

[Term]
id: GO:0070788
name: conidiophore stalk development
namespace: biological_process
def: "The process whose specific outcome is the progression of the conidiophore stalk over time, from its formation to the mature structure. The conidiophore stalk is part of a specialized hypha that extends aerially from the growth substrate and supports structures from which conidia, or asexual spores, develop." [PMID:9529886]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0070787 ! conidiophore development
created_by: midori
creation_date: 2009-07-08T01:31:44Z

[Term]
id: GO:0070789
name: metula development
namespace: biological_process
def: "The process whose specific outcome is the progression of metulae over time, from its formation to the mature structure. Metulae are elongated mononucleate cells that bud from the surface of the conidiophore tip." [PMID:9529886]
synonym: "development of primary sterigmata" EXACT [PMID:9529886]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0048468 ! cell development
relationship: part_of GO:0070787 ! conidiophore development
created_by: midori
creation_date: 2009-07-08T01:33:46Z

[Term]
id: GO:0070790
name: phialide development
namespace: biological_process
def: "The process whose specific outcome is the progression of phialides over time, from its formation to the mature structure. Phialides are specialized cells that bud from the ends of metulae on the conidiophore tip. Chains of conidia, or asexual spores, develop from the phialide tips." [PMID:9529886]
synonym: "development of secondary sterigmata" EXACT [PMID:9529886]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0048468 ! cell development
relationship: part_of GO:0070787 ! conidiophore development
created_by: midori
creation_date: 2009-07-08T02:32:30Z

[Term]
id: GO:0070791
name: cleistothecium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cleistothecium over time, from its formation to the mature structure. The cleistothecium is a closed sexual fruiting body that contains ascospores in linear asci, characteristic of some filamentous Ascomycete fungi such as members of the genera Aspergillus and Emericella." [ISBN:0471522295, PMID:17446882]
is_a: GO:0000909 ! sporocarp development involved in sexual reproduction
created_by: midori
creation_date: 2009-07-08T02:52:32Z

[Term]
id: GO:0070792
name: Hulle cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of Hulle cells over time, from their formation to the mature structures. Hulle cells are specialized multinucleate cells that originate from a nest-like aggregation of hyphae during sexual development and serve as nurse cells to the developing cleistothecium, or fruiting body." [PMID:19210625]
synonym: "Huelle cell development" EXACT [GOC:mah]
synonym: "Hulle cell formation" NARROW [PMID:19210625]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0048468 ! cell development
relationship: part_of GO:0070791 ! cleistothecium development
created_by: midori
creation_date: 2009-07-08T02:54:30Z

[Term]
id: GO:0070793
name: regulation of conidiophore development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of conidiophore development, a process that leads to the formation of a conidiophore. The conidiophore is a specialized hypha that extends aerially from the growth substrate and bears conidia, or asexual spores." [GOC:mah]
is_a: GO:0075260 ! regulation of spore-bearing organ development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070787 ! conidiophore development
relationship: regulates GO:0070787 ! conidiophore development
created_by: midori
creation_date: 2009-07-08T03:04:29Z

[Term]
id: GO:0070794
name: negative regulation of conidiophore development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of conidiophore development, a process that leads to the formation of a conidiophore. The conidiophore is a specialized hypha that extends aerially from the growth substrate and bears conidia, or asexual spores." [GOC:mah]
is_a: GO:0070793 ! regulation of conidiophore development
is_a: GO:0075262 ! negative regulation of spore-bearing organ development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070787 ! conidiophore development
relationship: negatively_regulates GO:0070787 ! conidiophore development
created_by: midori
creation_date: 2009-07-08T03:06:48Z

[Term]
id: GO:0070795
name: positive regulation of conidiophore development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of conidiophore development, a process that leads to the formation of a conidiophore. The conidiophore is a specialized hypha that extends aerially from the growth substrate and bears conidia, or asexual spores." [GOC:mah]
is_a: GO:0070793 ! regulation of conidiophore development
is_a: GO:0075261 ! positive regulation of spore-bearing organ development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070787 ! conidiophore development
relationship: positively_regulates GO:0070787 ! conidiophore development
created_by: midori
creation_date: 2009-07-08T03:08:29Z

[Term]
id: GO:0070796
name: regulation of cleistothecium development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cleistothecium development, a process that leads to the formation of a cleistothecium. The cleistothecium is a closed sexual fruiting body that contains ascospores in linear asci, characteristic of some filamentous Ascomycete fungi such as members of the genera Aspergillus and Emericella." [GOC:mah]
is_a: GO:1902058 ! regulation of sporocarp development involved in sexual reproduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070791 ! cleistothecium development
relationship: regulates GO:0070791 ! cleistothecium development
created_by: midori
creation_date: 2009-07-08T03:30:04Z

[Term]
id: GO:0070797
name: negative regulation of cleistothecium development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cleistothecium development, a process that leads to the formation of a cleistothecium. The cleistothecium is a closed sexual fruiting body that contains ascospores in linear asci, characteristic of some filamentous Ascomycete fungi such as members of the genera Aspergillus and Emericella." [GOC:mah]
is_a: GO:0070796 ! regulation of cleistothecium development
is_a: GO:1902059 ! negative regulation of sporocarp development involved in sexual reproduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070791 ! cleistothecium development
relationship: negatively_regulates GO:0070791 ! cleistothecium development
created_by: midori
creation_date: 2009-07-08T03:36:12Z

[Term]
id: GO:0070798
name: positive regulation of cleistothecium development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cleistothecium development, a process that leads to the formation of a cleistothecium. The cleistothecium is a closed sexual fruiting body that contains ascospores in linear asci, characteristic of some filamentous Ascomycete fungi such as members of the genera Aspergillus and Emericella." [GOC:mah]
is_a: GO:0070796 ! regulation of cleistothecium development
is_a: GO:1902060 ! positive regulation of sporocarp development involved in sexual reproduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070791 ! cleistothecium development
relationship: positively_regulates GO:0070791 ! cleistothecium development
created_by: midori
creation_date: 2009-07-08T03:36:43Z

[Term]
id: GO:0070799
name: regulation of conidiophore stalk development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of conidiophore stalk development, a process that leads to the formation of a conidiophore stalk. The conidiophore stalk is part of a specialized hypha that extends aerially from the growth substrate and supports structures from which conidia, or asexual spores, develop." [GOC:mah]
is_a: GO:0070793 ! regulation of conidiophore development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070788 ! conidiophore stalk development
relationship: regulates GO:0070788 ! conidiophore stalk development
created_by: midori
creation_date: 2009-07-08T04:03:40Z

[Term]
id: GO:0070800
name: negative regulation of conidiophore stalk development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of conidiophore stalk development, a process that leads to the formation of a conidiophore stalk. The conidiophore stalk is part of a specialized hypha that extends aerially from the growth substrate and supports structures from which conidia, or asexual spores, develop." [GOC:mah]
is_a: GO:0070794 ! negative regulation of conidiophore development
is_a: GO:0070799 ! regulation of conidiophore stalk development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070788 ! conidiophore stalk development
relationship: negatively_regulates GO:0070788 ! conidiophore stalk development
created_by: midori
creation_date: 2009-07-08T04:10:42Z

[Term]
id: GO:0070801
name: positive regulation of conidiophore stalk development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of conidiophore stalk development, a process that leads to the formation of a conidiophore stalk. The conidiophore stalk is part of a specialized hypha that extends aerially from the growth substrate and supports structures from which conidia, or asexual spores, develop." [GOC:mah]
is_a: GO:0070795 ! positive regulation of conidiophore development
is_a: GO:0070799 ! regulation of conidiophore stalk development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070788 ! conidiophore stalk development
relationship: positively_regulates GO:0070788 ! conidiophore stalk development
created_by: midori
creation_date: 2009-07-08T04:11:22Z

[Term]
id: GO:0070802
name: regulation of metula development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of metula development, a process that leads to the formation of metulae. Metulae are elongated mononucleate cells that bud from the surface of the conidiophore tip." [GOC:mah]
is_a: GO:0060284 ! regulation of cell development
is_a: GO:0070793 ! regulation of conidiophore development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070789 ! metula development
relationship: regulates GO:0070789 ! metula development
created_by: midori
creation_date: 2009-07-08T04:14:34Z

[Term]
id: GO:0070803
name: negative regulation of metula development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of metula development, a process that leads to the formation of metulae. Metulae are elongated mononucleate cells that bud from the surface of the conidiophore tip." [GOC:mah]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0070794 ! negative regulation of conidiophore development
is_a: GO:0070802 ! regulation of metula development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070789 ! metula development
relationship: negatively_regulates GO:0070789 ! metula development
created_by: midori
creation_date: 2009-07-08T04:38:04Z

[Term]
id: GO:0070804
name: positive regulation of metula development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of metula development, a process that leads to the formation of metulae. Metulae are elongated mononucleate cells that bud from the surface of the conidiophore tip." [GOC:mah]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0070795 ! positive regulation of conidiophore development
is_a: GO:0070802 ! regulation of metula development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070789 ! metula development
relationship: positively_regulates GO:0070789 ! metula development
created_by: midori
creation_date: 2009-07-08T04:38:33Z

[Term]
id: GO:0070805
name: regulation of phialide development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phialide development, a process that leads to the formation of phialides. Phialides are specialized cells that bud from the ends of metulae on the conidiophore tip." [GOC:mah]
is_a: GO:0060284 ! regulation of cell development
is_a: GO:0070793 ! regulation of conidiophore development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070790 ! phialide development
relationship: regulates GO:0070790 ! phialide development
created_by: midori
creation_date: 2009-07-08T04:45:03Z

[Term]
id: GO:0070806
name: negative regulation of phialide development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of phialide development, a process that leads to the formation of phialides. Phialides are specialized cells that bud from the ends of metulae on the conidiophore tip." [GOC:mah]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0070794 ! negative regulation of conidiophore development
is_a: GO:0070805 ! regulation of phialide development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070790 ! phialide development
relationship: negatively_regulates GO:0070790 ! phialide development
created_by: midori
creation_date: 2009-07-08T04:47:16Z

[Term]
id: GO:0070807
name: positive regulation of phialide development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phialide development, a process that leads to the formation of phialides. Phialides are specialized cells that bud from the ends of metulae on the conidiophore tip." [GOC:mah]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0070795 ! positive regulation of conidiophore development
is_a: GO:0070805 ! regulation of phialide development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070790 ! phialide development
relationship: positively_regulates GO:0070790 ! phialide development
created_by: midori
creation_date: 2009-07-08T04:48:08Z

[Term]
id: GO:0070808
name: regulation of Hulle cell development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Hulle cell development, a process that leads to the formation of Hulle cells. Hulle cells are specialized multinucleate cells that originate from a nest-like aggregation of hyphae during sexual development and serve as nurse cells to the developing cleistothecium, or fruiting body." [GOC:mah]
is_a: GO:0060284 ! regulation of cell development
is_a: GO:0070796 ! regulation of cleistothecium development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070792 ! Hulle cell development
relationship: regulates GO:0070792 ! Hulle cell development
created_by: midori
creation_date: 2009-07-08T04:51:33Z

[Term]
id: GO:0070809
name: negative regulation of Hulle cell development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Hulle cell development, a process that leads to the formation of Hulle cells. Hulle cells are specialized multinucleate cells that originate from a nest-like aggregation of hyphae during sexual development and serve as nurse cells to the developing cleistothecium, or fruiting body." [GOC:mah]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0070797 ! negative regulation of cleistothecium development
is_a: GO:0070808 ! regulation of Hulle cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070792 ! Hulle cell development
relationship: negatively_regulates GO:0070792 ! Hulle cell development
created_by: midori
creation_date: 2009-07-08T04:53:11Z

[Term]
id: GO:0070810
name: positive regulation of Hulle cell development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of Hulle cell development, a process that leads to the formation of Hulle cells. Hulle cells are specialized multinucleate cells that originate from a nest-like aggregation of hyphae during sexual development and serve as nurse cells to the developing cleistothecium, or fruiting body." [GOC:mah]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0070798 ! positive regulation of cleistothecium development
is_a: GO:0070808 ! regulation of Hulle cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070792 ! Hulle cell development
relationship: positively_regulates GO:0070792 ! Hulle cell development
created_by: midori
creation_date: 2009-07-08T04:54:12Z

[Term]
id: GO:0070811
name: glycerol-2-phosphate transport
namespace: biological_process
def: "The directed movement of glycerol-2-phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glycerol-2-phosphate is a phosphoric monoester of glycerol." [GOC:mah]
subset: gosubset_prok
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015748 ! organophosphate ester transport
is_a: GO:1901264 ! carbohydrate derivative transport
created_by: midori
creation_date: 2009-07-08T04:57:38Z

[Term]
id: GO:0070812
name: glycerol-2-phosphate-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + glycerol-2-phosphate(out) = ADP + phosphate + glycerol-2-phosphate(in)." [GOC:mah]
subset: gosubset_prok
is_a: GO:0015166 ! polyol transmembrane transporter activity
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances
relationship: part_of GO:0070811 ! glycerol-2-phosphate transport
created_by: midori
creation_date: 2009-07-08T05:01:33Z

[Term]
id: GO:0070813
name: hydrogen sulfide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving hydrogen sulfide, H2S." [CHEBI:16136, GOC:mah]
synonym: "hydrogen sulfide metabolism" EXACT [GOC:mah]
synonym: "hydrogen sulphide metabolic process" EXACT [GOC:mah]
synonym: "hydrogen sulphide metabolism" EXACT [GOC:mah]
is_a: GO:0006790 ! sulfur compound metabolic process
created_by: midori
creation_date: 2009-07-09T10:37:32Z

[Term]
id: GO:0070814
name: hydrogen sulfide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of hydrogen sulfide, H2S." [CHEBI:16136, GOC:mah]
synonym: "hydrogen sulfide anabolism" EXACT [GOC:mah]
synonym: "hydrogen sulfide biosynthesis" EXACT [GOC:mah]
synonym: "hydrogen sulfide formation" EXACT [GOC:mah]
synonym: "hydrogen sulfide synthesis" EXACT [GOC:mah]
synonym: "hydrogen sulphide biosynthesis" EXACT [GOC:mah]
synonym: "hydrogen sulphide biosynthetic process" EXACT [GOC:mah]
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:0070813 ! hydrogen sulfide metabolic process
created_by: midori
creation_date: 2009-07-09T10:45:02Z

[Term]
id: GO:0070815
name: peptidyl-lysine 5-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein L-lysine + 2-oxoglutarate + O2 = protein 5-hydroxy-L-lysine + succinate + CO2." [PMID:19574390]
synonym: "lysine hydroxylase activity" BROAD [GOC:mah]
synonym: "lysine,2-oxoglutarate 5-dioxygenase activity" BROAD [GOC:mah]
synonym: "lysine-2-oxoglutarate dioxygenase activity" BROAD [GOC:mah]
synonym: "lysyl hydroxylase activity" BROAD [GOC:mah]
synonym: "peptide-lysine 5-dioxygenase activity" EXACT [GOC:mah]
synonym: "peptidyl-lysine, 2-oxoglutarate: oxygen oxidoreductase activity" EXACT [EC:1.14.11.4, GOC:mah]
synonym: "peptidyllysine, 2-oxoglutarate:oxygen 5-oxidoreductase activity" EXACT [EC:1.14.11.4, GOC:mah]
synonym: "protein lysine hydroxylase activity" EXACT [GOC:mah]
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
created_by: midori
creation_date: 2009-07-09T11:42:07Z

[Term]
id: GO:0070816
name: phosphorylation of RNA polymerase II C-terminal domain
namespace: biological_process
alt_id: GO:0016245
def: "The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex." [GOC:krc, GOC:mah, PMID:17079683]
synonym: "CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:mah]
synonym: "generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:krc]
synonym: "generation of II(0) form of RNA polymerase II" EXACT [GOC:krc]
synonym: "hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:krc]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0006468 ! protein phosphorylation
created_by: midori
creation_date: 2009-07-13T04:01:19Z

[Term]
id: GO:0070817
name: P-TEFb-cap methyltransferase complex localization
namespace: biological_process
def: "Any process in which the P-TEFb-cap methyltransferase complex is transported to, or maintained in, a specific location." [GOC:mah]
synonym: "establishment and maintenance of P-TEFb-cap methyltransferase complex localization" EXACT [GOC:MAH]
synonym: "P-TEFb-cap methyltransferase complex localisation" EXACT [GOC:mah]
is_a: GO:0034629 ! cellular protein complex localization
created_by: midori
creation_date: 2009-07-13T04:20:17Z

[Term]
id: GO:0070818
name: protoporphyrinogen oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: protoporphyrinogen IX + acceptor = protoporphyrin IX + reduced acceptor." [EC:1.3.3.4, GOC:mah, PMID:19583219]
subset: gosubset_prok
synonym: "protoporphyrinogen IX oxidase activity" EXACT [EC:1.3.3.4]
synonym: "protoporphyrinogen-IX oxidase activity" EXACT [EC:1.3.3.4]
synonym: "protoporphyrinogenase activity" EXACT [EC:1.3.3.4]
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors
created_by: midori
creation_date: 2009-07-20T02:41:12Z

[Term]
id: GO:0070819
name: menaquinone-dependent protoporphyrinogen oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: protoporphyrinogen IX + menaquinone = protoporphyrin IX + reduced menaquinone." [GOC:mah, PMID:19583219]
subset: gosubset_prok
synonym: "protoporphyrinogen-IX:menaquinone oxidoreductase activity" EXACT [GOC:mah]
is_a: GO:0016635 ! oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor
is_a: GO:0070818 ! protoporphyrinogen oxidase activity
created_by: midori
creation_date: 2009-07-20T02:46:06Z

[Term]
id: GO:0070820
name: tertiary granule
namespace: cellular_component
def: "A secretory granule that contains cathepsin and gelatinase and is readily exocytosed upon cell activation; found primarily in mature neutrophil cells." [GOC:BHF, GOC:mah, GOC:rl, PMID:12070036]
synonym: "gelatinase granule" EXACT [PMID:23650620]
is_a: GO:0030141 ! secretory granule
created_by: midori
creation_date: 2009-07-20T03:57:00Z

[Term]
id: GO:0070821
name: tertiary granule membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a tertiary granule." [GOC:BHF, GOC:mah, GOC:rl, PMID:12070036]
is_a: GO:0030667 ! secretory granule membrane
relationship: part_of GO:0070820 ! tertiary granule
created_by: midori
creation_date: 2009-07-20T03:59:41Z

[Term]
id: GO:0070822
name: Sin3-type complex
namespace: cellular_component
def: "Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex." [PMID:15565322, PMID:18292778]
is_a: GO:0000118 ! histone deacetylase complex
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000790 ! nuclear chromatin
created_by: midori
creation_date: 2009-07-20T04:32:33Z

[Term]
id: GO:0070823
name: HDA1 complex
namespace: cellular_component
def: "A tetrameric histone deacetylase complex that contains a Class II deacetylase catalytic subunit. In S. cerevisiae it is composed of two Hda1p subunits along with Hda2p and Hda3p." [GOC:dgf, GOC:mah, PMID:11287668, PMID:8663039]
is_a: GO:0000118 ! histone deacetylase complex
is_a: GO:0000790 ! nuclear chromatin
created_by: midori
creation_date: 2009-07-20T04:47:11Z

[Term]
id: GO:0070824
name: SHREC complex
namespace: cellular_component
def: "A histone deacetylase complex that contains a core of four proteins -- Clr1, Clr2, Clr3, and Mit1 in fission yeast -- and localizes to all heterochromatic regions in the genome as well as some euchromatic sites. The complex is involved in regulating nucleosome positioning to assemble higher-order chromatin structures." [GOC:mah, PMID:17289569]
is_a: GO:0000118 ! histone deacetylase complex
is_a: GO:0090568 ! nuclear transcriptional repressor complex
created_by: midori
creation_date: 2009-07-20T05:02:12Z

[Term]
id: GO:0070825
name: micropyle
namespace: cellular_component
def: "An external encapsulating structure part of the chorion. A single cone-shaped specialization that forms an opening in the chorion that allows sperm entry into the egg prior to fertilization." [GOC:cvs, GOC:mah, PMID:18649270]
is_a: GO:0044462 ! external encapsulating structure part
relationship: part_of GO:0042600 ! chorion
created_by: midori
creation_date: 2009-07-21T05:33:09Z

[Term]
id: GO:0070826
name: paraferritin complex
namespace: cellular_component
def: "A cytoplasmic protein complex that contains integrin, mobilferrin and a flavin monooxygenase, is capable of reducing Fe(III) to Fe(II) utilizing NADPH, and is involved in iron transport. Fe(II) is required in the cell as the substrate for ferrochelatase in the synthesis of heme." [GOC:mah, GOC:rph, PMID:11842004, PMID:8639593]
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part
created_by: midori
creation_date: 2009-07-23T03:05:08Z

[Term]
id: GO:0070827
name: chromatin maintenance
namespace: biological_process
def: "The chromatin organization process that preserves chromatin in a stable functional or structural state." [GOC:mah]
is_a: GO:0006325 ! chromatin organization
is_a: GO:0043954 ! cellular component maintenance
is_a: GO:1902589 ! single-organism organelle organization
created_by: midori
creation_date: 2009-07-23T04:09:59Z

[Term]
id: GO:0070828
name: heterochromatin organization
namespace: biological_process
def: "Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin, a compact and highly condensed form of chromatin." [GOC:mah]
synonym: "heterochromatin organisation" EXACT [GOC:mah]
is_a: GO:0006325 ! chromatin organization
created_by: midori
creation_date: 2009-07-23T04:12:48Z

[Term]
id: GO:0070829
name: heterochromatin maintenance
namespace: biological_process
def: "The chromatin organization process that preserves heterochromatin in a stable functional or structural state." [GOC:mah]
is_a: GO:0070827 ! chromatin maintenance
is_a: GO:0070828 ! heterochromatin organization
created_by: midori
creation_date: 2009-07-23T04:14:49Z

[Term]
id: GO:0070830
name: bicellular tight junction assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a tight junction, an occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet." [GOC:mah]
synonym: "tight junction formation" EXACT [GOC:mah]
xref: Reactome:REACT_105729 "Tight junction interactions, Mus musculus"
xref: Reactome:REACT_106449 "Tight junction interactions, Gallus gallus"
xref: Reactome:REACT_108472 "Tight junction interactions, Danio rerio"
xref: Reactome:REACT_108481 "Tight junction interactions, Taeniopygia guttata"
xref: Reactome:REACT_19373 "Tight junction interactions, Homo sapiens"
xref: Reactome:REACT_80291 "Tight junction interactions, Sus scrofa"
xref: Reactome:REACT_82424 "Tight junction interactions, Xenopus tropicalis"
xref: Reactome:REACT_83192 "Tight junction interactions, Canis familiaris"
xref: Reactome:REACT_83981 "Tight junction interactions, Bos taurus"
xref: Reactome:REACT_97275 "Tight junction interactions, Rattus norvegicus"
is_a: GO:0007043 ! cell-cell junction assembly
relationship: part_of GO:0043297 ! apical junction assembly
created_by: midori
creation_date: 2009-07-23T04:32:38Z

[Term]
id: GO:0070831
name: basement membrane assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a basement membrane, a part of the extracellular region that consists of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue." [GOC:mah]
comment: Note that this term has no relationship to 'membrane assembly ; GO:0071709' because the basement membrane is not a lipid bilayer.
is_a: GO:0071711 ! basement membrane organization
is_a: GO:0085029 ! extracellular matrix assembly
created_by: midori
creation_date: 2009-07-23T05:01:51Z

[Term]
id: GO:0070832
name: phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via N-dimethylethanolamine phosphate and CDP-choline
namespace: biological_process
def: "The phosphatidylcholine biosynthetic process that begins with three consecutive N-methylation steps that are carried out on phospho-bases, phosphoethanolamine, phospho-N-methylethanolamine, and phospho-N-dimethylethanolamine; the process ends with the conversion of a phosphatidyl-N-dimethylethanolamine to a phosphatidylcholine." [MetaCyc:PWY4FS-2]
xref: MetaCyc:PWY4FS-2
is_a: GO:0006656 ! phosphatidylcholine biosynthetic process
is_a: GO:1901160 ! primary amino compound metabolic process
created_by: midori
creation_date: 2009-07-29T03:49:14Z

[Term]
id: GO:0070833
name: phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via CDP-N-methylethanolamine
namespace: biological_process
def: "The phosphatidylcholine biosynthetic process that begins with an initial N-methylation with phospho-base phosphoethanolamine, followed by two downstream N-methylations on phosphatidyl-bases, phosphatidyl-N-methylethanolamine and phosphatidyl-N-dimethylethanolamine. The process ends with the conversion of a phosphatidyl-N-dimethylethanolamine to a phosphatidylcholine." [MetaCyc:PWY4FS-3]
xref: MetaCyc:PWY4FS-3
is_a: GO:0006656 ! phosphatidylcholine biosynthetic process
is_a: GO:1901160 ! primary amino compound metabolic process
created_by: midori
creation_date: 2009-07-29T03:51:39Z

[Term]
id: GO:0070834
name: phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via N-dimethylethanolamine phosphate and CDP-N-dimethylethanolamine
namespace: biological_process
def: "The phosphatidylcholine biosynthetic process that begins with two N-methylations with phospho-base phosphoethanolamine and phospho-N-methylethanolamine, followed by a downstream N-methylation on phosphatidyl-base phosphatidyl-N-dimethylethanolamine; the process ends with the conversion of a phosphatidyl-N-dimethylethanolamine to a phosphatidylcholine." [MetaCyc:PWY4FS-4]
xref: MetaCyc:PWY4FS-4
is_a: GO:0006656 ! phosphatidylcholine biosynthetic process
is_a: GO:1901160 ! primary amino compound metabolic process
created_by: midori
creation_date: 2009-07-29T03:54:47Z

[Term]
id: GO:0070835
name: chromium ion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of chromium (Cr) ions from one side of a membrane to the other." [GOC:mah, GOC:yaf]
is_a: GO:0046915 ! transition metal ion transmembrane transporter activity
created_by: midori
creation_date: 2009-07-30T03:04:09Z

[Term]
id: GO:0070836
name: caveola assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a caveola. A caveola is a plasma membrane raft that forms a small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane." [GOC:BHF, GOC:mah, GOC:vk, PMID:12633858]
synonym: "caveola formation" EXACT [GOC:mah]
synonym: "caveolar biogenesis" RELATED [PMID:12633858]
is_a: GO:0044854 ! plasma membrane raft assembly
created_by: midori
creation_date: 2009-07-30T04:45:54Z

[Term]
id: GO:0070837
name: dehydroascorbic acid transport
namespace: biological_process
def: "The directed movement of dehydroascorbate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, is an oxidized form of vitamin C." [GOC:sl]
synonym: "dehydroascorbate transport" EXACT [GOC:sl]
is_a: GO:0015711 ! organic anion transport
is_a: GO:0051180 ! vitamin transport
created_by: midori
creation_date: 2009-07-30T05:24:31Z

[Term]
id: GO:0070838
name: divalent metal ion transport
namespace: biological_process
def: "The directed movement of divalent metal cations, any metal ion with a +2 electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
subset: gosubset_prok
is_a: GO:0030001 ! metal ion transport
is_a: GO:0072511 ! divalent inorganic cation transport
created_by: midori
creation_date: 2009-07-31T01:02:39Z

[Term]
id: GO:0070839
name: divalent metal ion export
namespace: biological_process
def: "The directed movement of divalent metal cations, any metal ion with a +2 electric charge, out of a cell or organelle." [GOC:mah]
is_a: GO:0070838 ! divalent metal ion transport
created_by: midori
creation_date: 2009-07-31T01:07:46Z

[Term]
id: GO:0070840
name: dynein complex binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity." [GOC:BHF, GOC:mah]
is_a: GO:0032403 ! protein complex binding
created_by: midori
creation_date: 2009-07-31T01:22:47Z

[Term]
id: GO:0070841
name: inclusion body assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an inclusion body." [GOC:BHF, GOC:mah]
is_a: GO:0022607 ! cellular component assembly
created_by: midori
creation_date: 2009-07-31T01:28:14Z

[Term]
id: GO:0070842
name: aggresome assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an aggresome; requires the microtubule cytoskeleton and dynein." [GOC:BHF, GOC:rl, PMID:14675537]
is_a: GO:0070841 ! inclusion body assembly
created_by: midori
creation_date: 2009-07-31T01:30:25Z

[Term]
id: GO:0070843
name: misfolded protein transport
namespace: biological_process
def: "The directed movement of misfolded proteins in a cell, including the movement of proteins between specific compartments or structures within a cell." [GOC:BHF, GOC:mah, PMID:14675537]
is_a: GO:0006886 ! intracellular protein transport
is_a: GO:1902582 ! single-organism intracellular transport
created_by: midori
creation_date: 2009-07-31T12:50:00Z

[Term]
id: GO:0070844
name: polyubiquitinated protein transport
namespace: biological_process
def: "The directed movement of polyubiquitinated proteins in a cell, including the movement of proteins between specific compartments or structures within a cell." [GOC:BHF, GOC:mah, PMID:14675537]
synonym: "polyubiquitylated protein transport" EXACT [GOC:mah]
is_a: GO:0006886 ! intracellular protein transport
is_a: GO:1902582 ! single-organism intracellular transport
created_by: midori
creation_date: 2009-07-31T12:51:10Z

[Term]
id: GO:0070845
name: polyubiquitinated misfolded protein transport
namespace: biological_process
def: "The directed movement of misfolded polyubiquitinated proteins in a cell, including the movement of proteins between specific compartments or structures within a cell." [GOC:BHF, GOC:mah, PMID:14675537]
synonym: "misfolded polyubiquitinated protein transport" RELATED [GOC:mah]
synonym: "polyubiquitylated misfolded protein transport" EXACT [GOC:mah]
is_a: GO:0070843 ! misfolded protein transport
is_a: GO:0070844 ! polyubiquitinated protein transport
created_by: midori
creation_date: 2009-07-31T12:52:26Z

[Term]
id: GO:0070846
name: Hsp90 deacetylation
namespace: biological_process
def: "The modification of an Hsp90 protein by removal of acetyl groups." [GOC:BHF, GOC:mah]
is_a: GO:0006476 ! protein deacetylation
created_by: midori
creation_date: 2009-07-31T12:58:47Z

[Term]
id: GO:0070847
name: core mediator complex
namespace: cellular_component
def: "A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]
synonym: "C mediator complex" EXACT [PMID:17870225]
synonym: "S mediator complex" EXACT [PMID:17043218]
is_a: GO:0044451 ! nucleoplasm part
is_a: GO:0090575 ! RNA polymerase II transcription factor complex
relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme
created_by: midori
creation_date: 2009-08-04T02:56:11Z

[Term]
id: GO:0070848
name: response to growth factor
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:BHF, GOC:mah]
synonym: "response to growth factor stimulus" EXACT [GOC:dos]
is_a: GO:0010033 ! response to organic substance
created_by: midori
creation_date: 2009-08-04T04:24:18Z

[Term]
id: GO:0070849
name: response to epidermal growth factor
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus." [GOC:BHF, GOC:mah]
synonym: "response to EGF stimulus" EXACT [GOC:mah]
synonym: "response to epidermal growth factor stimulus" EXACT [GOC:dos]
is_a: GO:0009719 ! response to endogenous stimulus
is_a: GO:0070848 ! response to growth factor
created_by: midori
creation_date: 2009-08-04T04:26:26Z

[Term]
id: GO:0070850
name: TACC/TOG complex
namespace: cellular_component
def: "A protein complex that contains the transforming acidic coiled coil (TACC) protein and the TOG protein (Mia1p/Alp7p and Alp14, respectively, in fission yeast), and is involved in microtubule array remodeling as cells progress through the cell cycle. The TACC/TOG complex is conserved in eukaryotes, associates with microtubules, and shuttles between the nucleus and the cytoplasm during interphase." [GOC:mah, GOC:vw, PMID:19606211]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
created_by: midori
creation_date: 2009-08-05T03:06:08Z

[Term]
id: GO:0070851
name: growth factor receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a growth factor receptor." [GOC:mah, GOC:vw]
is_a: GO:0005102 ! receptor binding
created_by: midori
creation_date: 2009-08-07T11:23:02Z

[Term]
id: GO:0070852
name: cell body fiber
namespace: cellular_component
def: "A neuron projection that is found in unipolar neurons and corresponds to the region between the cell body and the point at which the single projection branches." [GOC:dos, GOC:mah]
synonym: "cell body fibre" EXACT []
synonym: "primary neurite" RELATED [GOC:dos, GOC:mah]
is_a: GO:0043005 ! neuron projection
created_by: midori
creation_date: 2009-08-11T04:38:53Z

[Term]
id: GO:0070853
name: myosin VI binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a class VI myosin. The myosin VI heavy chain has a single IQ motif in the neck and a tail region with a coiled coil domain followed by a unique globular domain, a unique insertion that enables myosin VI to move towards the pointed or minus end of actin filaments." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, PMID:15473855]
is_a: GO:0017022 ! myosin binding
created_by: midori
creation_date: 2009-08-13T01:28:36Z

[Term]
id: GO:0070854
name: myosin VI heavy chain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a heavy chain of a myosin VI complex." [GOC:sart]
is_a: GO:0032036 ! myosin heavy chain binding
is_a: GO:0070853 ! myosin VI binding
created_by: midori
creation_date: 2009-08-13T01:44:05Z

[Term]
id: GO:0070855
name: myosin VI head/neck binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the head/neck region of a myosin VI heavy chain." [GOC:sart]
is_a: GO:0032028 ! myosin head/neck binding
is_a: GO:0070854 ! myosin VI heavy chain binding
created_by: midori
creation_date: 2009-08-13T01:45:08Z

[Term]
id: GO:0070856
name: myosin VI light chain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a light chain of a myosin VI complex." [GOC:sart]
is_a: GO:0032027 ! myosin light chain binding
is_a: GO:0070853 ! myosin VI binding
created_by: midori
creation_date: 2009-08-13T01:46:13Z

[Term]
id: GO:0070857
name: regulation of bile acid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids." [GOC:BHF, GOC:mah]
synonym: "regulation of bile acid anabolism" EXACT [GOC:mah]
synonym: "regulation of bile acid biosynthesis" EXACT [GOC:mah]
synonym: "regulation of bile acid formation" EXACT [GOC:mah]
synonym: "regulation of bile acid synthesis" EXACT [GOC:mah]
is_a: GO:0010565 ! regulation of cellular ketone metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0050810 ! regulation of steroid biosynthetic process
is_a: GO:1904251 ! regulation of bile acid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006699 ! bile acid biosynthetic process
relationship: regulates GO:0006699 ! bile acid biosynthetic process
created_by: midori
creation_date: 2009-08-14T03:09:02Z

[Term]
id: GO:0070858
name: negative regulation of bile acid biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids." [GOC:BHF, GOC:mah]
synonym: "down regulation of bile acid biosynthetic process" EXACT [GOC:mah]
synonym: "down-regulation of bile acid biosynthetic process" EXACT [GOC:mah]
synonym: "downregulation of bile acid biosynthetic process" EXACT [GOC:mah]
synonym: "inhibition of bile acid biosynthetic process" NARROW [GOC:mah]
synonym: "negative regulation of bile acid anabolism" EXACT [GOC:mah]
synonym: "negative regulation of bile acid biosynthesis" EXACT [GOC:mah]
synonym: "negative regulation of bile acid formation" EXACT [GOC:mah]
synonym: "negative regulation of bile acid synthesis" EXACT [GOC:mah]
is_a: GO:0010894 ! negative regulation of steroid biosynthetic process
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0070857 ! regulation of bile acid biosynthetic process
is_a: GO:1904252 ! negative regulation of bile acid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006699 ! bile acid biosynthetic process
relationship: negatively_regulates GO:0006699 ! bile acid biosynthetic process
created_by: midori
creation_date: 2009-08-14T03:16:40Z

[Term]
id: GO:0070859
name: positive regulation of bile acid biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids." [GOC:BHF, GOC:mah]
synonym: "activation of bile acid biosynthetic process" NARROW [GOC:mah]
synonym: "positive regulation of bile acid anabolism" EXACT [GOC:mah]
synonym: "positive regulation of bile acid biosynthesis" EXACT [GOC:mah]
synonym: "positive regulation of bile acid formation" EXACT [GOC:mah]
synonym: "positive regulation of bile acid synthesis" EXACT [GOC:mah]
synonym: "stimulation of bile acid biosynthetic process" NARROW [GOC:mah]
synonym: "up regulation of bile acid biosynthetic process" EXACT [GOC:mah]
synonym: "up-regulation of bile acid biosynthetic process" EXACT [GOC:mah]
synonym: "upregulation of bile acid biosynthetic process" EXACT [GOC:mah]
is_a: GO:0010893 ! positive regulation of steroid biosynthetic process
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0070857 ! regulation of bile acid biosynthetic process
is_a: GO:1904253 ! positive regulation of bile acid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006699 ! bile acid biosynthetic process
relationship: positively_regulates GO:0006699 ! bile acid biosynthetic process
created_by: midori
creation_date: 2009-08-14T03:22:58Z

[Term]
id: GO:0070860
name: RNA polymerase I core factor complex
namespace: cellular_component
def: "A RNA polymerase I-specific transcription factor complex that is required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrn6p, Rrn7p, and Rrn11p." [PMID:8702872]
comment: Note that, although this complex can be considered analogous to the mammalian transcription factor SL complex, the core factor complex does not include TBP, whereas SL1 does.
is_a: GO:0000120 ! RNA polymerase I transcription factor complex
created_by: midori
creation_date: 2009-08-14T05:00:44Z

[Term]
id: GO:0070861
name: regulation of protein exit from endoplasmic reticulum
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of proteins from the endoplasmic reticulum." [GOC:mah]
synonym: "regulation of protein exit from ER" EXACT [GOC:mah]
synonym: "regulation of protein export from endoplasmic reticulum" EXACT [GOC:mah]
synonym: "regulation of protein export from ER" EXACT [GOC:mah]
is_a: GO:0033157 ! regulation of intracellular protein transport
is_a: GO:1903649 ! regulation of cytoplasmic transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032527 ! protein exit from endoplasmic reticulum
relationship: regulates GO:0032527 ! protein exit from endoplasmic reticulum
created_by: midori
creation_date: 2009-08-17T03:39:18Z

[Term]
id: GO:0070862
name: negative regulation of protein exit from endoplasmic reticulum
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of proteins from the endoplasmic reticulum." [GOC:mah]
synonym: "down regulation of protein exit from endoplasmic reticulum" EXACT [GOC:mah]
synonym: "down-regulation of protein exit from endoplasmic reticulum" EXACT [GOC:mah]
synonym: "downregulation of protein exit from endoplasmic reticulum" EXACT [GOC:mah]
synonym: "inhibition of protein exit from endoplasmic reticulum" NARROW [GOC:mah]
synonym: "negative regulation of protein exit from ER" EXACT [GOC:mah]
synonym: "negative regulation of protein export from endoplasmic reticulum" EXACT [GOC:mah]
synonym: "negative regulation of protein export from ER" EXACT [GOC:mah]
is_a: GO:0070861 ! regulation of protein exit from endoplasmic reticulum
is_a: GO:0090317 ! negative regulation of intracellular protein transport
is_a: GO:1903650 ! negative regulation of cytoplasmic transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032527 ! protein exit from endoplasmic reticulum
relationship: negatively_regulates GO:0032527 ! protein exit from endoplasmic reticulum
created_by: midori
creation_date: 2009-08-17T03:45:56Z

[Term]
id: GO:0070863
name: positive regulation of protein exit from endoplasmic reticulum
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the endoplasmic reticulum." [GOC:mah]
synonym: "activation of protein exit from endoplasmic reticulum" NARROW [GOC:mah]
synonym: "positive regulation of protein exit from ER" EXACT [GOC:mah]
synonym: "positive regulation of protein export from endoplasmic reticulum" EXACT [GOC:mah]
synonym: "positive regulation of protein export from ER" EXACT [GOC:mah]
synonym: "stimulation of protein exit from endoplasmic reticulum" NARROW [GOC:mah]
synonym: "up regulation of protein exit from endoplasmic reticulum" EXACT [GOC:mah]
synonym: "up-regulation of protein exit from endoplasmic reticulum" EXACT [GOC:mah]
synonym: "upregulation of protein exit from endoplasmic reticulum" EXACT [GOC:mah]
is_a: GO:0070861 ! regulation of protein exit from endoplasmic reticulum
is_a: GO:0090316 ! positive regulation of intracellular protein transport
is_a: GO:1903651 ! positive regulation of cytoplasmic transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032527 ! protein exit from endoplasmic reticulum
relationship: positively_regulates GO:0032527 ! protein exit from endoplasmic reticulum
created_by: midori
creation_date: 2009-08-17T03:50:04Z

[Term]
id: GO:0070864
name: sperm individualization complex
namespace: cellular_component
def: "A macromolecular complex that includes cytoskeletal components and part of the cell membrane. Forms at the nuclear end of a male germline syncytium, or cyst, and translocates the over the length of the syncytium in the course of sperm individualization. Each complex contains an array of 64 investment cones, one per nucleus, that move synchronously along the spermatogenic cyst." [GOC:sart, PMID:10588662, PMID:9550716]
is_a: GO:0032991 ! macromolecular complex
is_a: GO:0044464 ! cell part
created_by: midori
creation_date: 2009-08-19T01:25:33Z

[Term]
id: GO:0070865
name: investment cone
namespace: cellular_component
def: "A cytoskeletal part that consists of a microfilament-rich cone that forms round each nucleus in a spermatogenic cyst and translocates the length of the cyst during sperm individualization." [GOC:sart, PMID:15829565, PMID:9550716]
synonym: "F-actin cone" EXACT [PMID:15829565]
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0070864 ! sperm individualization complex
created_by: midori
creation_date: 2009-08-19T01:29:33Z

[Term]
id: GO:0070866
name: sterol-dependent protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) in the presence of sterols." [GOC:ecd]
is_a: GO:0005515 ! protein binding
created_by: midori
creation_date: 2009-08-19T01:43:35Z

[Term]
id: GO:0070867
name: mating projection tip membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a mating projection tip." [GOC:mah]
is_a: GO:0044459 ! plasma membrane part
is_a: GO:0044463 ! cell projection part
relationship: part_of GO:0043332 ! mating projection tip
created_by: midori
creation_date: 2009-08-19T04:05:58Z

[Term]
id: GO:0070868
name: heterochromatin organization involved in chromatin silencing
namespace: biological_process
def: "Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin and contributes to chromatin silencing." [GOC:mah]
synonym: "heterochromatin organisation involved in chromatin silencing" EXACT [GOC:mah]
is_a: GO:0070828 ! heterochromatin organization
is_a: GO:0097549 ! chromatin organization involved in negative regulation of transcription
intersection_of: GO:0070828 ! heterochromatin organization
intersection_of: part_of GO:0006342 ! chromatin silencing
relationship: part_of GO:0006342 ! chromatin silencing
created_by: midori
creation_date: 2009-08-20T12:45:52Z

[Term]
id: GO:0070869
name: heterochromatin assembly involved in chromatin silencing
namespace: biological_process
def: "Any process that results in the assembly of chromatin into heterochromatin and contributes to chromatin silencing." [GOC:mah]
synonym: "heterochromatin formation involved in chromatin silencing" EXACT []
is_a: GO:0031507 ! heterochromatin assembly
is_a: GO:0070868 ! heterochromatin organization involved in chromatin silencing
intersection_of: GO:0031507 ! heterochromatin assembly
intersection_of: part_of GO:0006342 ! chromatin silencing
relationship: part_of GO:0006342 ! chromatin silencing
created_by: midori
creation_date: 2009-08-20T01:04:27Z

[Term]
id: GO:0070870
name: heterochromatin maintenance involved in chromatin silencing
namespace: biological_process
def: "A chromatin organization process that preserves heterochromatin in a stable functional or structural state, and that contributes to chromatin silencing." [GOC:mah]
is_a: GO:0070829 ! heterochromatin maintenance
is_a: GO:0070868 ! heterochromatin organization involved in chromatin silencing
intersection_of: GO:0070829 ! heterochromatin maintenance
intersection_of: part_of GO:0006342 ! chromatin silencing
relationship: part_of GO:0006342 ! chromatin silencing
created_by: midori
creation_date: 2009-08-20T01:08:43Z

[Term]
id: GO:0070871
name: cell wall organization involved in conjugation with cellular fusion
namespace: biological_process
def: "A process of cell wall organization that contributes to conjugation with cellular fusion." [GOC:mah]
synonym: "cell wall organisation involved in conjugation with cellular fusion" EXACT [GOC:mah]
is_a: GO:0022414 ! reproductive process
is_a: GO:0071555 ! cell wall organization
intersection_of: GO:0071555 ! cell wall organization
intersection_of: part_of GO:0000747 ! conjugation with cellular fusion
relationship: part_of GO:0000747 ! conjugation with cellular fusion
created_by: midori
creation_date: 2009-08-20T02:23:19Z

[Term]
id: GO:0070872
name: plasma membrane organization involved in conjugation with cellular fusion
namespace: biological_process
def: "A process of plasma membrane organization that contributes to conjugation with cellular fusion." [GOC:mah]
synonym: "plasma membrane organisation involved in conjugation with cellular fusion" EXACT [GOC:mah]
is_a: GO:0007009 ! plasma membrane organization
is_a: GO:0044702 ! single organism reproductive process
intersection_of: GO:0007009 ! plasma membrane organization
intersection_of: part_of GO:0000747 ! conjugation with cellular fusion
relationship: part_of GO:0000747 ! conjugation with cellular fusion
created_by: midori
creation_date: 2009-08-20T02:24:56Z

[Term]
id: GO:0070873
name: regulation of glycogen metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glycogen." [GOC:mah]
synonym: "regulation of glycogen metabolism" EXACT [GOC:mah]
is_a: GO:0010906 ! regulation of glucose metabolic process
is_a: GO:0032881 ! regulation of polysaccharide metabolic process
is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0005977 ! glycogen metabolic process
relationship: regulates GO:0005977 ! glycogen metabolic process
created_by: midori
creation_date: 2009-08-20T02:44:53Z

[Term]
id: GO:0070874
name: negative regulation of glycogen metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving glycogen." [GOC:mah]
synonym: "negative regulation of glycogen metabolism" EXACT [GOC:mah]
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process
is_a: GO:0070873 ! regulation of glycogen metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0005977 ! glycogen metabolic process
relationship: negatively_regulates GO:0005977 ! glycogen metabolic process
created_by: midori
creation_date: 2009-08-20T02:50:41Z

[Term]
id: GO:0070875
name: positive regulation of glycogen metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glycogen." [GOC:mah]
synonym: "positive regulation of glycogen metabolism" EXACT [GOC:mah]
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0010907 ! positive regulation of glucose metabolic process
is_a: GO:0070873 ! regulation of glycogen metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0005977 ! glycogen metabolic process
relationship: positively_regulates GO:0005977 ! glycogen metabolic process
created_by: midori
creation_date: 2009-08-20T02:53:55Z

[Term]
id: GO:0070876
name: SOSS complex
namespace: cellular_component
def: "A protein complex that functions downstream of the MRN complex to promote DNA repair and the G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and is composed of SOSS-B (SOSS-B1/OBFC2B or SOSS-B2/OBFC2A), SOSS-A/INTS3 and SOSS-C/C9orf80." [PMID:19683501]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part
created_by: midori
creation_date: 2009-08-20T03:30:48Z

[Term]
id: GO:0070877
name: microprocessor complex
namespace: cellular_component
def: "A protein complex that binds to heme and to pri-miRNAs, and is required for the formation of a pre-microRNA (pre-miRNA), the initial step of microRNA (miRNA) biogenesis. The complex is composed of the double-stranded-RNA-specific RNase Drosha (also called RNASEN) and the RNA-binding protein DGCR8 (heme-free or heme-bound forms). Within the complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs RNASEN/Drosha to cleave the 3' and 5' strands of a stem-loop to release hairpin-shaped pre-miRNAs." [PMID:16963499, PMID:17159994]
xref: IntAct:EBI-9519039
xref: IntAct:EBI-9519056
is_a: GO:0044428 ! nuclear part
is_a: GO:1903095 ! ribonuclease III complex
created_by: midori
creation_date: 2009-08-20T03:56:26Z

[Term]
id: GO:0070878
name: primary miRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a primary microRNA (pri-miRNA) transcript, an RNA molecule that is processed into a short hairpin-shaped structure called a pre-miRNA and finally into a functional miRNA. Both double-stranded and single-stranded regions of a pri-miRNA are required for binding." [GOC:sl, PMID:15531877, PMID:15574589]
synonym: "pri-miRNA binding" EXACT []
synonym: "primary microRNA binding" EXACT [PMID:15531877, PMID:15574589]
is_a: GO:0003723 ! RNA binding
created_by: midori
creation_date: 2009-08-20T04:11:36Z

[Term]
id: GO:0070879
name: fungal-type cell wall beta-glucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of fungal cells." [GOC:mah, GOC:vw]
synonym: "fungal-type cell wall beta-glucan metabolism" EXACT [GOC:mah]
is_a: GO:0034406 ! cell wall beta-glucan metabolic process
is_a: GO:0071966 ! fungal-type cell wall polysaccharide metabolic process
relationship: part_of GO:0009272 ! fungal-type cell wall biogenesis
created_by: midori
creation_date: 2009-08-21T02:46:09Z

[Term]
id: GO:0070880
name: fungal-type cell wall beta-glucan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of fungal cells." [GOC:mah]
synonym: "fungal-type cell wall beta-glucan anabolism" EXACT [GOC:mah]
synonym: "fungal-type cell wall beta-glucan biosynthesis" EXACT [GOC:mah]
synonym: "fungal-type cell wall beta-glucan formation" EXACT [GOC:mah]
synonym: "fungal-type cell wall beta-glucan synthesis" EXACT [GOC:mah]
is_a: GO:0051274 ! beta-glucan biosynthetic process
is_a: GO:0051278 ! fungal-type cell wall polysaccharide biosynthetic process
is_a: GO:0070879 ! fungal-type cell wall beta-glucan metabolic process
created_by: midori
creation_date: 2009-08-21T02:48:24Z

[Term]
id: GO:0070881
name: regulation of proline transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of proline transport." [GOC:mah]
is_a: GO:0051955 ! regulation of amino acid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0015824 ! proline transport
relationship: regulates GO:0015824 ! proline transport
created_by: midori
creation_date: 2009-08-21T04:48:34Z

[Term]
id: GO:0070883
name: pre-miRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a precursor microRNA (pre-miRNA) transcript, a stem-loop-containing precursor of microRNA." [PMID:18951094]
synonym: "pre-microRNA binding" EXACT [GOC:pr]
synonym: "precursor microRNA binding" EXACT [PMID:18951094]
is_a: GO:0003723 ! RNA binding
created_by: midori
creation_date: 2009-08-24T04:36:24Z

[Term]
id: GO:0070884
name: regulation of calcineurin-NFAT signaling cascade
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the calcineurin-NFAT signaling cascade." [GOC:ai]
synonym: "regulation of calcineurin-NFAT signaling pathway" RELATED [GOC:bf]
synonym: "regulation of calcineurin-NFAT signalling cascade" EXACT [GOC:mah]
is_a: GO:0050848 ! regulation of calcium-mediated signaling
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0033173 ! calcineurin-NFAT signaling cascade
relationship: regulates GO:0033173 ! calcineurin-NFAT signaling cascade
created_by: midori
creation_date: 2009-08-26T03:25:30Z

[Term]
id: GO:0070885
name: negative regulation of calcineurin-NFAT signaling cascade
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the calcineurin-NFAT signaling cascade." [GOC:mah]
synonym: "down regulation of calcineurin-NFAT signaling cascade" EXACT [GOC:mah]
synonym: "down-regulation of calcineurin-NFAT signaling cascade" EXACT [GOC:mah]
synonym: "downregulation of calcineurin-NFAT signaling cascade" EXACT [GOC:mah]
synonym: "inhibition of calcineurin-NFAT signaling cascade" NARROW [GOC:mah]
synonym: "negative regulation of calcineurin-NFAT signaling pathway" RELATED [GOC:bf]
synonym: "negative regulation of calcineurin-NFAT signalling cascade" EXACT [GOC:mah]
synonym: "termination of calcineurin-NFAT signaling cascade" NARROW [GOC:bf]
is_a: GO:0050849 ! negative regulation of calcium-mediated signaling
is_a: GO:0070884 ! regulation of calcineurin-NFAT signaling cascade
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0033173 ! calcineurin-NFAT signaling cascade
relationship: negatively_regulates GO:0033173 ! calcineurin-NFAT signaling cascade
created_by: midori
creation_date: 2009-08-26T03:29:33Z

[Term]
id: GO:0070886
name: positive regulation of calcineurin-NFAT signaling cascade
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of signaling via the calcineurin-NFAT signaling cascade." [GOC:mah]
synonym: "activation of calcineurin-NFAT signaling cascade" NARROW [GOC:mah]
synonym: "positive regulation of calcineurin-NFAT signaling pathway" RELATED [GOC:bf]
synonym: "positive regulation of calcineurin-NFAT signalling cascade" EXACT [GOC:mah]
synonym: "stimulation of calcineurin-NFAT signaling cascade" NARROW [GOC:mah]
synonym: "up regulation of calcineurin-NFAT signaling cascade" EXACT [GOC:mah]
synonym: "up-regulation of calcineurin-NFAT signaling cascade" EXACT [GOC:mah]
synonym: "upregulation of calcineurin-NFAT signaling cascade" EXACT [GOC:mah]
is_a: GO:0050850 ! positive regulation of calcium-mediated signaling
is_a: GO:0070884 ! regulation of calcineurin-NFAT signaling cascade
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0033173 ! calcineurin-NFAT signaling cascade
relationship: positively_regulates GO:0033173 ! calcineurin-NFAT signaling cascade
created_by: midori
creation_date: 2009-08-26T03:37:10Z

[Term]
id: GO:0070887
name: cellular response to chemical stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
is_a: GO:0042221 ! response to chemical
is_a: GO:0051716 ! cellular response to stimulus
created_by: midori
creation_date: 2009-08-27T04:41:45Z

[Term]
id: GO:0070888
name: E-box binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues." [GOC:BHF, GOC:vk, PMID:11812799]
comment: Note that as agreed during the transcription overhaul, terms specifying binding to specific transcription regulatory motifs are no longer being created. The level of specificity GO has decided to go to is the "core promoter", "core promoter proximal region" and "enhancer". To capture more detail, please consider using column 16.
synonym: "E-box promoter binding" EXACT [GOC:vk]
is_a: GO:0044212 ! transcription regulatory region DNA binding
created_by: midori
creation_date: 2009-08-28T10:37:01Z

[Term]
id: GO:0070889
name: platelet alpha granule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a platelet alpha granule. A platelet alpha granule is a secretory organelle found in blood platelets." [GOC:rph, PMID:16123220]
synonym: "platelet alpha granule organisation" EXACT [GOC:mah]
synonym: "platelet alpha granule organization and biogenesis" RELATED [GOC:mah]
synonym: "platelet alpha-granule organization" EXACT [GOC:mah]
is_a: GO:0033363 ! secretory granule organization
created_by: midori
creation_date: 2009-08-28T10:43:31Z

[Term]
id: GO:0070890
name: sodium-dependent L-ascorbate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-ascorbate(out) + Na+(out) = L-ascorbate(in) + Na+(in)." [GOC:mah, GOC:yaf, PMID:18094143]
is_a: GO:0015145 ! monosaccharide transmembrane transporter activity
is_a: GO:0015229 ! L-ascorbic acid transporter activity
is_a: GO:0015370 ! solute:sodium symporter activity
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity
is_a: GO:0090482 ! vitamin transmembrane transporter activity
created_by: midori
creation_date: 2009-09-01T02:25:22Z

[Term]
id: GO:0070891
name: lipoteichoic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with lipoteichoic acid." [GOC:add, PMID:14665680]
is_a: GO:0097367 ! carbohydrate derivative binding
created_by: midori
creation_date: 2009-09-01T02:56:36Z

[Term]
id: GO:0070892
name: lipoteichoic acid receptor activity
namespace: molecular_function
def: "Combining with lipoteichoic acid and transmitting the signal to initiate a change in cell activity." [GOC:add, PMID:14665680]
is_a: GO:0008329 ! signaling pattern recognition receptor activity
relationship: has_part GO:0070891 ! lipoteichoic acid binding
created_by: midori
creation_date: 2009-09-01T02:59:24Z

[Term]
id: GO:0070893
name: transposon integration
namespace: biological_process
def: "Any process in which a transposable element is incorporated into another DNA molecule such as a chromosome." [GOC:jp, PMID:10882723]
is_a: GO:0015074 ! DNA integration
is_a: GO:0032196 ! transposition
is_a: GO:0044710 ! single-organism metabolic process
created_by: midori
creation_date: 2009-09-01T04:08:19Z

[Term]
id: GO:0070894
name: regulation of transposon integration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of regulation of transposon integration, a process in which a transposable element is incorporated into another DNA molecule." [GOC:mah]
is_a: GO:0010528 ! regulation of transposition
is_a: GO:0051052 ! regulation of DNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070893 ! transposon integration
relationship: regulates GO:0070893 ! transposon integration
created_by: midori
creation_date: 2009-09-01T04:14:09Z

[Term]
id: GO:0070895
name: negative regulation of transposon integration
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transposon integration, a process in which a transposable element is incorporated into another DNA molecule." [GOC:mah]
synonym: "down regulation of transposon integration" EXACT [GOC:mah]
synonym: "down-regulation of transposon integration" EXACT [GOC:mah]
synonym: "downregulation of transposon integration" EXACT [GOC:mah]
synonym: "inhibition of transposon integration" NARROW [GOC:mah]
is_a: GO:0010529 ! negative regulation of transposition
is_a: GO:0051053 ! negative regulation of DNA metabolic process
is_a: GO:0070894 ! regulation of transposon integration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070893 ! transposon integration
relationship: negatively_regulates GO:0070893 ! transposon integration
created_by: midori
creation_date: 2009-09-01T04:20:36Z

[Term]
id: GO:0070896
name: positive regulation of transposon integration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transposon integration, a process in which a transposable element is incorporated into another DNA molecule." [GOC:mah]
synonym: "activation of transposon integration" NARROW [GOC:mah]
synonym: "stimulation of transposon integration" NARROW [GOC:mah]
synonym: "up regulation of transposon integration" EXACT [GOC:mah]
synonym: "up-regulation of transposon integration" EXACT [GOC:mah]
synonym: "upregulation of transposon integration" EXACT [GOC:mah]
is_a: GO:0010530 ! positive regulation of transposition
is_a: GO:0051054 ! positive regulation of DNA metabolic process
is_a: GO:0070894 ! regulation of transposon integration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070893 ! transposon integration
relationship: positively_regulates GO:0070893 ! transposon integration
created_by: midori
creation_date: 2009-09-01T04:25:06Z

[Term]
id: GO:0070897
name: DNA-templated transcriptional preinitiation complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription." [GOC:jp, GOC:txnOH]
synonym: "DNA-dependent transcriptional preinitiation complex assembly" EXACT [GOC:txnOH]
synonym: "transcription PIC biosynthesis" BROAD [GOC:mah]
synonym: "transcription PIC formation" BROAD [GOC:mah]
synonym: "transcriptional preinitiation complex formation" BROAD [GOC:mah]
is_a: GO:0065004 ! protein-DNA complex assembly
relationship: part_of GO:0006352 ! DNA-templated transcription, initiation
created_by: midori
creation_date: 2009-09-01T04:33:47Z

[Term]
id: GO:0070898
name: RNA polymerase III transcriptional preinitiation complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase III promoter." [GOC:jp, GOC:txnOH, PMID:11387215]
synonym: "RNA polymerase III transcription PIC biosynthesis" EXACT [GOC:mah]
synonym: "RNA polymerase III transcription PIC formation" EXACT [GOC:mah]
synonym: "RNA polymerase III transcriptional preinitiation complex formation" EXACT [GOC:mah]
is_a: GO:0070897 ! DNA-templated transcriptional preinitiation complex assembly
relationship: part_of GO:0006384 ! transcription initiation from RNA polymerase III promoter
created_by: midori
creation_date: 2009-09-01T04:47:18Z

[Term]
id: GO:0070899
name: mitochondrial tRNA wobble uridine modification
namespace: biological_process
def: "The process in which a uridine in position 34 of a mitochondrial tRNA is post-transcriptionally modified." [GOC:mah, GOC:mcc]
is_a: GO:0002098 ! tRNA wobble uridine modification
is_a: GO:0070900 ! mitochondrial tRNA modification
intersection_of: GO:0002098 ! tRNA wobble uridine modification
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion
created_by: midori
creation_date: 2009-09-02T03:14:13Z

[Term]
id: GO:0070900
name: mitochondrial tRNA modification
namespace: biological_process
def: "The covalent alteration of one or more nucleotides within a mitochondrial tRNA molecule to produce a mitochondrial tRNA molecule with a sequence that differs from that coded genetically." [GOC:mah, GOC:mcc]
is_a: GO:0000963 ! mitochondrial RNA processing
is_a: GO:0006400 ! tRNA modification
is_a: GO:0070525 ! tRNA threonylcarbamoyladenosine metabolic process
is_a: GO:1900864 ! mitochondrial RNA modification
intersection_of: GO:0006400 ! tRNA modification
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion
created_by: midori
creation_date: 2009-09-02T03:16:53Z

[Term]
id: GO:0070901
name: mitochondrial tRNA methylation
namespace: biological_process
def: "The posttranscriptional addition of methyl groups to specific residues in a mitochondrial tRNA molecule." [GOC:mah, GOC:mcc]
is_a: GO:0030488 ! tRNA methylation
is_a: GO:0070900 ! mitochondrial tRNA modification
intersection_of: GO:0030488 ! tRNA methylation
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion
created_by: midori
creation_date: 2009-09-02T04:08:00Z

[Term]
id: GO:0070902
name: mitochondrial tRNA pseudouridine synthesis
namespace: biological_process
def: "The intramolecular conversion of uridine to pseudouridine in a mitochondrial tRNA molecule." [GOC:mah, GOC:mcc]
is_a: GO:0031119 ! tRNA pseudouridine synthesis
is_a: GO:0070900 ! mitochondrial tRNA modification
intersection_of: GO:0031119 ! tRNA pseudouridine synthesis
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion
created_by: midori
creation_date: 2009-09-02T04:09:48Z

[Term]
id: GO:0070903
name: mitochondrial tRNA thio-modification
namespace: biological_process
def: "The addition a sulfur atom to a nucleotide in a mitochondrial tRNA molecule." [GOC:mah, GOC:mcc]
is_a: GO:0034227 ! tRNA thio-modification
is_a: GO:0070900 ! mitochondrial tRNA modification
intersection_of: GO:0034227 ! tRNA thio-modification
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion
created_by: midori
creation_date: 2009-09-02T04:11:17Z

[Term]
id: GO:0070904
name: transepithelial L-ascorbic acid transport
namespace: biological_process
def: "The directed movement of L-ascorbic acid from one side of an epithelium to the other." [GOC:mah, GOC:yaf]
synonym: "transepithelial L-ascorbate transport" EXACT [GOC:mah]
synonym: "transepithelial vitamin C transport" EXACT [GOC:mah]
is_a: GO:0015882 ! L-ascorbic acid transport
is_a: GO:0070633 ! transepithelial transport
created_by: midori
creation_date: 2009-09-03T02:21:25Z

[Term]
id: GO:0070905
name: serine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with 2-amino-3-hydroxypropanoic acid." [CHEBI:17822, GOC:rph]
synonym: "Ser binding" EXACT [GOC:mah]
is_a: GO:0016597 ! amino acid binding
is_a: GO:0043169 ! cation binding
created_by: midori
creation_date: 2009-09-04T03:28:29Z

[Term]
id: GO:0070906
name: aspartate:alanine antiporter activity
namespace: molecular_function
def: "Catalysis of the reaction: aspartate(out) + alanine(in) = aspartate(in) + alanine(out)." [GOC:dh]
synonym: "aspartate-alanine antiporter activity" EXACT [GOC:mah]
synonym: "aspartate/alanine antiporter activity" EXACT [GOC:mah]
xref: RHEA:33142
is_a: GO:0015301 ! anion:anion antiporter activity
is_a: GO:0015556 ! C4-dicarboxylate transmembrane transporter activity
is_a: GO:0022858 ! alanine transmembrane transporter activity
created_by: midori
creation_date: 2009-09-04T03:44:15Z

[Term]
id: GO:0070907
name: histidine:histamine antiporter activity
namespace: molecular_function
def: "Catalysis of the reaction: histidine(out) + histamine(in) = histidine(in) + histamine(out)." [GOC:dh]
synonym: "histidine-histamine antiporter activity" EXACT [GOC:mah]
synonym: "histidine/histamine antiporter activity" EXACT [GOC:mah]
is_a: GO:0008519 ! ammonium transmembrane transporter activity
is_a: GO:0015171 ! amino acid transmembrane transporter activity
is_a: GO:0015491 ! cation:cation antiporter activity
is_a: GO:1901474 ! azole transmembrane transporter activity
created_by: midori
creation_date: 2009-09-04T03:47:07Z

[Term]
id: GO:0070908
name: tyrosine:tyramine antiporter activity
namespace: molecular_function
def: "Catalysis of the reaction: tyrosine(out) + tyramine(in) = tyrosine(in) + tyramine(out)." [GOC:dh]
synonym: "tyrosine-tyramine antiporter activity" EXACT [GOC:mah]
synonym: "tyrosine/tyramine antiporter activity" EXACT [GOC:mah]
is_a: GO:0008504 ! monoamine transmembrane transporter activity
is_a: GO:0008519 ! ammonium transmembrane transporter activity
is_a: GO:0015173 ! aromatic amino acid transmembrane transporter activity
is_a: GO:0015491 ! cation:cation antiporter activity
is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity
created_by: midori
creation_date: 2009-09-04T03:49:45Z

[Term]
id: GO:0070909
name: glutamate:gamma-aminobutyric acid antiporter activity
namespace: molecular_function
def: "Catalysis of the reaction: tyrosine(out) + tyramine(in) = tyrosine(in) + tyramine(out)." [GOC:dh]
synonym: "glutamate-gamma-aminobutyric acid antiporter activity" EXACT [GOC:mah]
synonym: "glutamate/gamma-aminobutyric acid antiporter activity" EXACT [GOC:mah]
synonym: "glutamate: GABA antiporter activity" EXACT [GOC:dh]
is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity
is_a: GO:0015185 ! gamma-aminobutyric acid transmembrane transporter activity
is_a: GO:0015301 ! anion:anion antiporter activity
created_by: midori
creation_date: 2009-09-04T03:51:32Z

[Term]
id: GO:0070910
name: cell wall macromolecule catabolic process involved in cell wall disassembly
namespace: biological_process
def: "The chemical reactions and pathways that result in the breakdown of macromolecules that form part of a cell wall, and contributes to the breakdown of the cell wall." [GOC:mah]
is_a: GO:0016998 ! cell wall macromolecule catabolic process
intersection_of: GO:0016998 ! cell wall macromolecule catabolic process
intersection_of: part_of GO:0044277 ! cell wall disassembly
relationship: part_of GO:0044277 ! cell wall disassembly
created_by: midori
creation_date: 2009-09-09T02:40:57Z

[Term]
id: GO:0070911
name: global genome nucleotide-excision repair
namespace: biological_process
def: "The nucleotide-excision repair process in which DNA lesions are removed from nontranscribed strands and from transcriptionally silent regions over the entire genome." [PMID:10197977, PMID:18794354]
subset: gosubset_prok
synonym: "GG-NER" EXACT [PMID:10197977]
synonym: "GGR" EXACT [GOC:vw, PMID:18794354]
synonym: "global genome NER" EXACT [GOC:mah]
synonym: "global genomic nucleotide-excision repair" EXACT [GOC:mah, GOC:vw]
synonym: "global genomic repair" EXACT [GOC:vw, PMID:18794354]
is_a: GO:0006289 ! nucleotide-excision repair
created_by: midori
creation_date: 2009-09-09T03:13:11Z

[Term]
id: GO:0070912
name: Ddb1-Ckn1 complex
namespace: cellular_component
def: "A heterodimeric nucleotide-excision repair complex that is involved in transcription-coupled repair. The subunits are known as Ddb1 and Ckn1 in S. pombe; Ddb1 contains a motif called the DDB-box that interacts with adaptor proteins for DDB1/cullin 4 ubiquitin ligases." [PMID:18794354]
is_a: GO:0000109 ! nucleotide-excision repair complex
created_by: midori
creation_date: 2009-09-09T03:41:04Z

[Term]
id: GO:0070913
name: Ddb1-Wdr21 complex
namespace: cellular_component
def: "A heterodimeric nucleotide-excision repair complex that is involved in transcription-coupled repair. The subunits are known as Ddb1 and Wdr21 in S. pombe; Ddb1 contains a motif called the DDB-box that interacts with adaptor proteins for DDB1/cullin 4 ubiquitin ligases." [PMID:18794354]
is_a: GO:0000109 ! nucleotide-excision repair complex
created_by: midori
creation_date: 2009-09-09T03:47:54Z

[Term]
id: GO:0070914
name: UV-damage excision repair
namespace: biological_process
def: "A DNA repair process that is initiated by an endonuclease that introduces a single-strand incision immediately 5' of a UV-induced damage site. UV-damage excision repair acts on both cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone 6-4 photoproducts (6-4PPs)." [GOC:mah, PMID:9619100]
synonym: "AER" RELATED [GOC:mah, PMID:10704216]
synonym: "alternative excision repair" RELATED [GOC:mah, PMID:10704216]
synonym: "UV-damaged DNA endonuclease-dependent excision repair" EXACT [GOC:vw]
synonym: "UVDE-dependent excision repair" EXACT [GOC:vw, PMID:9619100]
synonym: "UVER" EXACT [GOC:vw, PMID:9619100]
is_a: GO:0006281 ! DNA repair
is_a: GO:0034644 ! cellular response to UV
created_by: midori
creation_date: 2009-09-10T03:14:06Z

[Term]
id: GO:0070915
name: lysophosphatidic acid receptor activity
namespace: molecular_function
def: "Combining with the phospholipid derivative lysophosphatidic acid, and transmitting the signal across the membrane by activating an associated G-protein." [CHEBI:52288, GOC:bf, GOC:mah, PMID:15755723]
synonym: "LPA receptor activity" EXACT [PMID:15755723]
is_a: GO:0045125 ! bioactive lipid receptor activity
relationship: has_part GO:0035727 ! lysophosphatidic acid binding
created_by: midori
creation_date: 2009-09-10T05:05:13Z

[Term]
id: GO:0070916
name: inositol phosphoceramide synthase complex
namespace: cellular_component
def: "A protein complex that possesses inositol phosphoceramide synthase activity and contains a catalytic subunit and a regulatory subunit (Aur1p and Kei1p, respectively, in Saccharomyces)." [GOC:mah, PMID:19726565]
synonym: "IPC synthase complex" EXACT [GOC:mah]
is_a: GO:0044431 ! Golgi apparatus part
is_a: GO:1990234 ! transferase complex
created_by: midori
creation_date: 2009-09-10T05:23:21Z

[Term]
id: GO:0070917
name: inositol phosphoceramide synthase regulator activity
namespace: molecular_function
def: "Modulates the activity of inositol phosphoceramide synthase." [GOC:mah]
comment: See also the molecular function term 'histone acetyltransferase activity ; GO:0004402'.
synonym: "IPC synthase regulator activity" EXACT []
is_a: GO:0030234 ! enzyme regulator activity
relationship: regulates GO:0045140 ! inositol phosphoceramide synthase activity
created_by: midori
creation_date: 2009-09-10T05:27:06Z

[Term]
id: GO:0070918
name: production of small RNA involved in gene silencing by RNA
namespace: biological_process
def: "The process in which a double-stranded RNA precursor is processed into short (20-30 nt) fragments. RNA cleavage is catalyzed by a Dicer endonuclease." [GOC:mah, PMID:19239886]
synonym: "gene silencing by RNA, production of guide RNA" EXACT [GOC:mah]
synonym: "gene silencing by RNA, production of small RNA" EXACT [GOC:mah]
is_a: GO:0031050 ! dsRNA fragmentation
relationship: part_of GO:0031047 ! gene silencing by RNA
created_by: midori
creation_date: 2009-09-11T03:32:19Z

[Term]
id: GO:0070919
name: production of siRNA involved in chromatin silencing by small RNA
namespace: biological_process
def: "Cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of chromatin silencing by small RNA." [GOC:mah, PMID:19239886]
synonym: "chromatin silencing by small RNA, production of guide RNAs" EXACT []
synonym: "chromatin silencing by small RNA, production of siRNA" EXACT [GOC:mah]
synonym: "production of guide RNAs involved in chromatin silencing by small RNA" EXACT [GOC:mah]
is_a: GO:0070918 ! production of small RNA involved in gene silencing by RNA
relationship: part_of GO:0031048 ! chromatin silencing by small RNA
created_by: midori
creation_date: 2009-09-11T03:39:18Z

[Term]
id: GO:0070920
name: regulation of production of small RNA involved in gene silencing by RNA
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the production of small RNA involved in gene silencing by RNA." [GOC:mah]
synonym: "regulation of gene silencing by RNA, production of guide RNA" EXACT [GOC:mah]
synonym: "regulation of gene silencing by RNA, production of small RNA" EXACT [GOC:mah]
is_a: GO:0048583 ! regulation of response to stimulus
is_a: GO:0051252 ! regulation of RNA metabolic process
is_a: GO:0060966 ! regulation of gene silencing by RNA
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070918 ! production of small RNA involved in gene silencing by RNA
relationship: regulates GO:0070918 ! production of small RNA involved in gene silencing by RNA
created_by: midori
creation_date: 2009-09-11T03:41:59Z

[Term]
id: GO:0070921
name: regulation of production of siRNA involved in chromatin silencing by small RNA
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the production of siRNA, the cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of chromatin silencing by small RNA." [GOC:mah]
synonym: "regulation of chromatin silencing by small RNA, production of siRNA" EXACT [GOC:mah]
is_a: GO:0010964 ! regulation of chromatin silencing by small RNA
is_a: GO:0070920 ! regulation of production of small RNA involved in gene silencing by RNA
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070919 ! production of siRNA involved in chromatin silencing by small RNA
relationship: regulates GO:0070919 ! production of siRNA involved in chromatin silencing by small RNA
created_by: midori
creation_date: 2009-09-11T03:42:51Z

[Term]
id: GO:0070922
name: small RNA loading onto RISC
namespace: biological_process
def: "The process in which a single-stranded small RNA associates with the RNA-initiated silencing complex (RISC); occurs as part of a process of gene silencing by small RNA." [GOC:mah, PMID:19239886]
synonym: "gene silencing by RNA, small RNA loading onto RISC" EXACT [GOC:mah]
synonym: "RISC assembly" RELATED [GOC:mah]
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0031047 ! gene silencing by RNA
created_by: midori
creation_date: 2009-09-11T03:57:38Z

[Term]
id: GO:0070923
name: siRNA loading onto RISC involved in chromatin silencing by small RNA
namespace: biological_process
def: "The process in which a single-stranded small RNA associates with the RNA-initiated silencing complex (RISC); occurs as part of a process of chromatin silencing by small RNA." [GOC:mah, PMID:19239886]
synonym: "chromatin silencing by small RNA, siRNA loading onto RISC" EXACT [GOC:mah]
is_a: GO:0070922 ! small RNA loading onto RISC
relationship: part_of GO:0031048 ! chromatin silencing by small RNA
created_by: midori
creation_date: 2009-09-11T04:01:44Z

[Term]
id: GO:0070924
name: heterochromatin assembly involved in chromatin silencing by small RNA
namespace: biological_process
def: "The process in which an siRNA-associated RNA-induced silencing complex (siRISC) associates with nascent transcripts and RNA polymerase to induce the formation of heterochromatin." [GOC:mah, PMID:19239886]
synonym: "chromatin silencing by small RNA, heterochromatin formation" EXACT [GOC:mah]
synonym: "heterochromatin formation involved in chromatin silencing by small RNA" EXACT []
synonym: "small RNA-mediated heterochromatin biosynthesis" EXACT [GOC:mah]
synonym: "small RNA-mediated heterochromatin formation" EXACT [GOC:mah]
is_a: GO:0070869 ! heterochromatin assembly involved in chromatin silencing
intersection_of: GO:0031507 ! heterochromatin assembly
intersection_of: part_of GO:0031048 ! chromatin silencing by small RNA
relationship: part_of GO:0031048 ! chromatin silencing by small RNA
created_by: midori
creation_date: 2009-09-11T04:10:51Z

[Term]
id: GO:0070925
name: organelle assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah]
subset: goslim_yeast
is_a: GO:0006996 ! organelle organization
is_a: GO:0022607 ! cellular component assembly
created_by: midori
creation_date: 2009-09-15T03:00:51Z

[Term]
id: GO:0070926
name: regulation of ATP:ADP antiporter activity
namespace: biological_process
def: "Any process that modulates the activity of an ATP:ADP antiporter." [GOC:BHF, GOC:mah]
is_a: GO:0032242 ! regulation of nucleoside transport
is_a: GO:0032412 ! regulation of ion transmembrane transporter activity
is_a: GO:1903959 ! regulation of anion transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0005471 ! ATP:ADP antiporter activity
relationship: regulates GO:0005471 ! ATP:ADP antiporter activity
created_by: midori
creation_date: 2009-09-16T02:56:35Z

[Term]
id: GO:0070927
name: negative regulation of ATP:ADP antiporter activity
namespace: biological_process
def: "Any process that stops or reduces the activity of an ATP:ADP antiporter." [GOC:BHF, GOC:mah]
synonym: "down regulation of ATP:ADP antiporter activity" EXACT [GOC:mah]
synonym: "down-regulation of ATP:ADP antiporter activity" EXACT [GOC:mah]
synonym: "downregulation of ATP:ADP antiporter activity" EXACT [GOC:mah]
synonym: "inhibition of ATP:ADP antiporter activity" NARROW [GOC:mah]
is_a: GO:0032243 ! negative regulation of nucleoside transport
is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity
is_a: GO:0070926 ! regulation of ATP:ADP antiporter activity
is_a: GO:1903960 ! negative regulation of anion transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0005471 ! ATP:ADP antiporter activity
relationship: negatively_regulates GO:0005471 ! ATP:ADP antiporter activity
created_by: midori
creation_date: 2009-09-16T02:58:02Z

[Term]
id: GO:0070928
name: regulation of mRNA stability, ncRNA-mediated
namespace: biological_process
def: "Any process, mediated by small non-coding RNAs, that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs." [GOC:jh2]
synonym: "ncRNA-mediated regulation of mRNA stability" EXACT [GOC:mah]
synonym: "regulation of mRNA stability, non-coding RNA-mediated" EXACT [GOC:mah]
is_a: GO:0043488 ! regulation of mRNA stability
created_by: midori
creation_date: 2009-09-16T03:26:21Z

[Term]
id: GO:0070929
name: trans-translation
namespace: biological_process
def: "A translational elongation process in which transfer of a translating ribosome from one mRNA to another RNA template takes place. Trans-translation occurs during tmRNA release of stalled ribosomes." [GOC:jh2, GOC:mah]
is_a: GO:0006414 ! translational elongation
created_by: midori
creation_date: 2009-09-16T04:06:12Z

[Term]
id: GO:0070930
name: trans-translation-dependent protein tagging
namespace: biological_process
def: "A protein modification process in which a polypeptide is added to a nascent polypeptide cotranslationally by trans-translation." [GOC:jh2, GOC:jsg, GOC:mah]
comment: Note that this term is not a child of 'co-translational protein modification process ; GO:0043686' because co-translational protein modification implies modification of a previously incorporated amino acid in a nascent chain, rather than addition of new sequence to the C-terminus.
synonym: "co-translational protein tagging" EXACT [GOC:jh2, GOC:jsg]
synonym: "cotranslational protein tagging" EXACT [GOC:mah]
synonym: "protein modification by trans-translation" EXACT [GOC:mah]
is_a: GO:0006464 ! cellular protein modification process
relationship: has_part GO:0070929 ! trans-translation
created_by: midori
creation_date: 2009-09-16T04:10:49Z

[Term]
id: GO:0070931
name: Golgi-associated vesicle lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of a Golgi-associated vesicle." [GOC:mah]
is_a: GO:0044431 ! Golgi apparatus part
is_a: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen
relationship: part_of GO:0005798 ! Golgi-associated vesicle
created_by: midori
creation_date: 2009-09-16T04:26:50Z

[Term]
id: GO:0070932
name: histone H3 deacetylation
namespace: biological_process
def: "The modification of histone H3 by the removal of one or more acetyl groups." [GOC:BHF, GOC:rl]
is_a: GO:0016575 ! histone deacetylation
created_by: midori
creation_date: 2009-09-16T04:50:55Z

[Term]
id: GO:0070933
name: histone H4 deacetylation
namespace: biological_process
def: "The modification of histone H4 by the removal of one or more acetyl groups." [GOC:BHF, GOC:rl]
is_a: GO:0016575 ! histone deacetylation
created_by: midori
creation_date: 2009-09-16T04:53:06Z

[Term]
id: GO:0070934
name: CRD-mediated mRNA stabilization
namespace: biological_process
def: "An mRNA stabilization process in which one or more RNA-binding proteins associate with a sequence in the open reading frame called the coding region instability determinant (CRD)." [GOC:mah, PMID:19029303]
synonym: "coding region determinant-mediated mRNA stabilization" EXACT [GOC:mah]
is_a: GO:0048255 ! mRNA stabilization
created_by: midori
creation_date: 2009-09-21T02:57:06Z

[Term]
id: GO:0070935
name: 3'-UTR-mediated mRNA stabilization
namespace: biological_process
def: "An mRNA stabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA." [GOC:mah, PMID:19029303]
synonym: "3'-untranslated region-mediated mRNA stabilization" EXACT [GOC:mah]
is_a: GO:0048255 ! mRNA stabilization
created_by: midori
creation_date: 2009-09-21T03:08:20Z

[Term]
id: GO:0070936
name: protein K48-linked ubiquitination
namespace: biological_process
def: "A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation." [GOC:cvs, PMID:15556404]
synonym: "protein K48-linked polyubiquitination" EXACT [GOC:mah]
is_a: GO:0000209 ! protein polyubiquitination
created_by: midori
creation_date: 2009-09-21T03:25:27Z

[Term]
id: GO:0070937
name: CRD-mediated mRNA stability complex
namespace: cellular_component
def: "A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the coding region instability determinant (CRD). In human, IGF2BP1 and at least four additional proteins: HNRNPU, SYNCRIP, YBX1, and DHX9." [GOC:mah, PMID:19029303]
comment: See also the molecular function term 'alkyl hydroperoxide reductase activity ; GO:0008785'.
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part
created_by: midori
creation_date: 2009-09-22T02:00:22Z

[Term]
id: GO:0070938
name: contractile ring
namespace: cellular_component
def: "A cytoskeletal structure composed of filamentous protein that forms beneath the membrane of many cells or organelles, in the plane of cell or organelle division. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two daughter cells or organelles." [GOC:mah, ISBN:0123645859, ISBN:0792354923, PMID:10791428, PMID:17913889]
synonym: "constriction ring" RELATED [GOC:mah]
synonym: "cytokinetic ring" RELATED [GOC:mah]
is_a: GO:0044464 ! cell part
created_by: midori
creation_date: 2009-09-22T02:41:32Z

[Term]
id: GO:0070939
name: Dsl1p complex
namespace: cellular_component
def: "A multisubunit tethering complex, i.e. a protein complex involved in mediating the initial interaction between vesicles and the membranes with which they fuse, that is involved in trafficking from the Golgi apparatus to the ER. In Saccharomyces cerevisiae the Dsl1p complex contains Dsl1p, Tip20p, and Sec39p." [GOC:jh, GOC:mah, PMID:19151722]
comment: See also the molecular function term 'acetolactate synthase activity ; GO:0003984'.
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part
created_by: midori
creation_date: 2009-09-22T03:41:38Z

[Term]
id: GO:0070940
name: dephosphorylation of RNA polymerase II C-terminal domain
namespace: biological_process
def: "The process of removing a phosphate group from an amino acid residue in the C-terminal domain of RNA polymerase II. Some dephosphorylation occurs during transcription while some may occur after the enzyme is released from the template in order to prepare it for the beginning of the transcription cycle again. RNA polymerase II with little or no phosphorylation is referred to as the hypophosphorylated or II(A) form." [GOC:krc, GOC:mah, PMID:17079683]
synonym: "CTD domain dephosphorylation of RNA polymerase II" EXACT [GOC:mah]
synonym: "generation of hypophosphorylated CTD of RNA polymerase II" EXACT [GOC:krc]
synonym: "generation of II(A) form of RNA polymerase II" EXACT [GOC:krc]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0006470 ! protein dephosphorylation
created_by: midori
creation_date: 2009-09-29T04:34:14Z

[Term]
id: GO:0070941
name: eisosome assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an eisosome, a cell part that is composed of the eisosome membrane or MCC domain, a furrow-like plasma membrane sub-domain and associated integral transmembrane proteins, and the proteins (eisosome filaments) that form a scaffolding lattice on the cytoplasmic face." [GOC:al, GOC:jp, PMID:19564405]
is_a: GO:0022607 ! cellular component assembly
created_by: midori
creation_date: 2009-09-30T02:49:30Z

[Term]
id: GO:0070942
name: neutrophil mediated cytotoxicity
namespace: biological_process
def: "The directed killing of a target cell by a neutrophil." [GOC:add, ISBN:0781765196]
synonym: "neutrophil mediated cell killing" EXACT [GOC:add]
is_a: GO:0001909 ! leukocyte mediated cytotoxicity
is_a: GO:0002446 ! neutrophil mediated immunity
created_by: midori
creation_date: 2009-10-01T01:49:30Z

[Term]
id: GO:0070943
name: neutrophil mediated killing of symbiont cell
namespace: biological_process
def: "The directed killing of a symbiont target cell by a neutrophil." [GOC:add, ISBN:0781765196]
is_a: GO:0051873 ! killing by host of symbiont cells
is_a: GO:0070942 ! neutrophil mediated cytotoxicity
created_by: midori
creation_date: 2009-10-01T01:52:03Z

[Term]
id: GO:0070944
name: neutrophil mediated killing of bacterium
namespace: biological_process
def: "The directed killing of a bacterium by a neutrophil." [GOC:add, ISBN:0781765196]
is_a: GO:0070943 ! neutrophil mediated killing of symbiont cell
relationship: part_of GO:0042742 ! defense response to bacterium
created_by: midori
creation_date: 2009-10-01T01:55:56Z

[Term]
id: GO:0070945
name: neutrophil mediated killing of gram-negative bacterium
namespace: biological_process
def: "The directed killing of a gram-negative bacterium by a neutrophil." [GOC:add, ISBN:0781765196]
is_a: GO:0070944 ! neutrophil mediated killing of bacterium
relationship: part_of GO:0050829 ! defense response to Gram-negative bacterium
created_by: midori
creation_date: 2009-10-01T01:59:12Z

[Term]
id: GO:0070946
name: neutrophil mediated killing of gram-positive bacterium
namespace: biological_process
def: "The directed killing of a gram-positive bacterium by a neutrophil." [GOC:add, ISBN:0781765196]
is_a: GO:0070944 ! neutrophil mediated killing of bacterium
relationship: part_of GO:0050830 ! defense response to Gram-positive bacterium
created_by: midori
creation_date: 2009-10-01T02:04:15Z

[Term]
id: GO:0070947
name: neutrophil mediated killing of fungus
namespace: biological_process
def: "The directed killing of a fungal cell by a neutrophil." [GOC:add, ISBN:0781765196]
is_a: GO:0070943 ! neutrophil mediated killing of symbiont cell
relationship: part_of GO:0050832 ! defense response to fungus
created_by: midori
creation_date: 2009-10-01T02:07:44Z

[Term]
id: GO:0070948
name: regulation of neutrophil mediated cytotoxicity
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a target cell, the directed killing of a target cell by a neutrophil." [GOC:add, GOC:mah]
synonym: "regulation of neutrophil mediated cell killing" EXACT [GOC:add]
is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity
is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070942 ! neutrophil mediated cytotoxicity
relationship: regulates GO:0070942 ! neutrophil mediated cytotoxicity
created_by: midori
creation_date: 2009-10-01T02:14:36Z

[Term]
id: GO:0070949
name: regulation of neutrophil mediated killing of symbiont cell
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a symbiont cell, the directed killing of a symbiont target cell by a neutrophil." [GOC:add, GOC:mah]
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0032101 ! regulation of response to external stimulus
is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism
is_a: GO:0051709 ! regulation of killing of cells of other organism
is_a: GO:0070948 ! regulation of neutrophil mediated cytotoxicity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070943 ! neutrophil mediated killing of symbiont cell
relationship: regulates GO:0070943 ! neutrophil mediated killing of symbiont cell
created_by: midori
creation_date: 2009-10-01T02:14:36Z

[Term]
id: GO:0070950
name: regulation of neutrophil mediated killing of bacterium
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a bacterium, the directed killing of a bacterium by a neutrophil." [GOC:add, GOC:mah]
is_a: GO:0070949 ! regulation of neutrophil mediated killing of symbiont cell
is_a: GO:1900424 ! regulation of defense response to bacterium
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070944 ! neutrophil mediated killing of bacterium
relationship: regulates GO:0070944 ! neutrophil mediated killing of bacterium
created_by: midori
creation_date: 2009-10-01T02:14:36Z

[Term]
id: GO:0070951
name: regulation of neutrophil mediated killing of gram-negative bacterium
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a gram-negative bacterium, the directed killing of a gram-negative bacterium by a neutrophil." [GOC:add, GOC:mah]
is_a: GO:0070950 ! regulation of neutrophil mediated killing of bacterium
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070945 ! neutrophil mediated killing of gram-negative bacterium
relationship: regulates GO:0070945 ! neutrophil mediated killing of gram-negative bacterium
created_by: midori
creation_date: 2009-10-01T02:14:36Z

[Term]
id: GO:0070952
name: regulation of neutrophil mediated killing of gram-positive bacterium
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a gram-positive bacterium, the directed killing of a gram-positive bacterium by a neutrophil." [GOC:add, GOC:mah]
is_a: GO:0070950 ! regulation of neutrophil mediated killing of bacterium
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070946 ! neutrophil mediated killing of gram-positive bacterium
relationship: regulates GO:0070946 ! neutrophil mediated killing of gram-positive bacterium
created_by: midori
creation_date: 2009-10-01T02:14:36Z

[Term]
id: GO:0070953
name: regulation of neutrophil mediated killing of fungus
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a fungal cell, the directed killing of a fungal cell by a neutrophil." [GOC:add, GOC:mah]
is_a: GO:0070949 ! regulation of neutrophil mediated killing of symbiont cell
is_a: GO:1900150 ! regulation of defense response to fungus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070947 ! neutrophil mediated killing of fungus
relationship: regulates GO:0070947 ! neutrophil mediated killing of fungus
created_by: midori
creation_date: 2009-10-01T02:14:36Z

[Term]
id: GO:0070954
name: negative regulation of neutrophil mediated cytotoxicity
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the directed killing of a target cell by a neutrophil." [GOC:add, GOC:mah]
synonym: "down regulation of neutrophil mediated cytotoxicity" EXACT [GOC:mah]
synonym: "down-regulation of neutrophil mediated cytotoxicity" EXACT [GOC:mah]
synonym: "downregulation of neutrophil mediated cytotoxicity" EXACT [GOC:mah]
synonym: "inhibition of neutrophil mediated cytotoxicity" NARROW [GOC:mah]
synonym: "negative regulation of neutrophil mediated cell killing" EXACT [GOC:add]
is_a: GO:0001911 ! negative regulation of leukocyte mediated cytotoxicity
is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity
is_a: GO:0070948 ! regulation of neutrophil mediated cytotoxicity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070942 ! neutrophil mediated cytotoxicity
relationship: negatively_regulates GO:0070942 ! neutrophil mediated cytotoxicity
created_by: midori
creation_date: 2009-10-01T02:20:17Z

[Term]
id: GO:0070955
name: negative regulation of neutrophil mediated killing of symbiont cell
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the directed killing of a symbiont target cell by a neutrophil." [GOC:add, GOC:mah]
synonym: "down regulation of neutrophil mediated killing of symbiont cell" EXACT [GOC:mah]
synonym: "down-regulation of neutrophil mediated killing of symbiont cell" EXACT [GOC:mah]
synonym: "downregulation of neutrophil mediated killing of symbiont cell" EXACT [GOC:mah]
synonym: "inhibition of neutrophil mediated killing of symbiont cell" NARROW [GOC:mah]
is_a: GO:0002832 ! negative regulation of response to biotic stimulus
is_a: GO:0031348 ! negative regulation of defense response
is_a: GO:0032102 ! negative regulation of response to external stimulus
is_a: GO:0051711 ! negative regulation of killing of cells of other organism
is_a: GO:0070949 ! regulation of neutrophil mediated killing of symbiont cell
is_a: GO:0070954 ! negative regulation of neutrophil mediated cytotoxicity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070943 ! neutrophil mediated killing of symbiont cell
relationship: negatively_regulates GO:0070943 ! neutrophil mediated killing of symbiont cell
created_by: midori
creation_date: 2009-10-01T02:20:17Z

[Term]
id: GO:0070956
name: negative regulation of neutrophil mediated killing of bacterium
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the directed killing of a bacterium by a neutrophil." [GOC:add, GOC:mah]
synonym: "down regulation of neutrophil mediated killing of bacterium" EXACT [GOC:mah]
synonym: "down-regulation of neutrophil mediated killing of bacterium" EXACT [GOC:mah]
synonym: "downregulation of neutrophil mediated killing of bacterium" EXACT [GOC:mah]
synonym: "inhibition of neutrophil mediated killing of bacterium" NARROW [GOC:mah]
is_a: GO:0070950 ! regulation of neutrophil mediated killing of bacterium
is_a: GO:0070955 ! negative regulation of neutrophil mediated killing of symbiont cell
is_a: GO:1900425 ! negative regulation of defense response to bacterium
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070944 ! neutrophil mediated killing of bacterium
relationship: negatively_regulates GO:0070944 ! neutrophil mediated killing of bacterium
created_by: midori
creation_date: 2009-10-01T02:20:17Z

[Term]
id: GO:0070957
name: negative regulation of neutrophil mediated killing of gram-negative bacterium
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the directed killing of a gram-negative bacterium by a neutrophil." [GOC:add, GOC:mah]
synonym: "down regulation of neutrophil mediated killing of gram-negative bacterium" EXACT [GOC:mah]
synonym: "down-regulation of neutrophil mediated killing of gram-negative bacterium" EXACT [GOC:mah]
synonym: "downregulation of neutrophil mediated killing of gram-negative bacterium" EXACT [GOC:mah]
synonym: "inhibition of neutrophil mediated killing of gram-negative bacterium" NARROW [GOC:mah]
is_a: GO:0070951 ! regulation of neutrophil mediated killing of gram-negative bacterium
is_a: GO:0070956 ! negative regulation of neutrophil mediated killing of bacterium
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070945 ! neutrophil mediated killing of gram-negative bacterium
relationship: negatively_regulates GO:0070945 ! neutrophil mediated killing of gram-negative bacterium
created_by: midori
creation_date: 2009-10-01T02:20:17Z

[Term]
id: GO:0070958
name: negative regulation of neutrophil mediated killing of gram-positive bacterium
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the directed killing of a gram-positive bacterium by a neutrophil." [GOC:add, GOC:mah]
synonym: "down regulation of neutrophil mediated killing of gram-positive bacterium" EXACT [GOC:mah]
synonym: "down-regulation of neutrophil mediated killing of gram-positive bacterium" EXACT [GOC:mah]
synonym: "downregulation of neutrophil mediated killing of gram-positive bacterium" EXACT [GOC:mah]
synonym: "inhibition of neutrophil mediated killing of gram-positive bacterium" NARROW [GOC:mah]
is_a: GO:0070952 ! regulation of neutrophil mediated killing of gram-positive bacterium
is_a: GO:0070956 ! negative regulation of neutrophil mediated killing of bacterium
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070946 ! neutrophil mediated killing of gram-positive bacterium
relationship: negatively_regulates GO:0070946 ! neutrophil mediated killing of gram-positive bacterium
created_by: midori
creation_date: 2009-10-01T02:20:17Z

[Term]
id: GO:0070959
name: negative regulation of neutrophil mediated killing of fungus
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the directed killing of a fungal cell by a neutrophil." [GOC:add, GOC:mah]
synonym: "down regulation of neutrophil mediated killing of fungus" EXACT [GOC:mah]
synonym: "down-regulation of neutrophil mediated killing of fungus" EXACT [GOC:mah]
synonym: "downregulation of neutrophil mediated killing of fungus" EXACT [GOC:mah]
synonym: "inhibition of neutrophil mediated killing of fungus" NARROW [GOC:mah]
is_a: GO:0070953 ! regulation of neutrophil mediated killing of fungus
is_a: GO:0070955 ! negative regulation of neutrophil mediated killing of symbiont cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070947 ! neutrophil mediated killing of fungus
relationship: negatively_regulates GO:0070947 ! neutrophil mediated killing of fungus
created_by: midori
creation_date: 2009-10-01T02:20:17Z

[Term]
id: GO:0070960
name: positive regulation of neutrophil mediated cytotoxicity
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the directed killing of a target cell by a neutrophil." [GOC:add, GOC:mah]
synonym: "activation of neutrophil mediated cytotoxicity" NARROW [GOC:mah]
synonym: "positive regulation of neutrophil mediated cell killing" EXACT [GOC:add]
synonym: "stimulation of neutrophil mediated cytotoxicity" NARROW [GOC:mah]
synonym: "up regulation of neutrophil mediated cytotoxicity" EXACT [GOC:mah]
synonym: "up-regulation of neutrophil mediated cytotoxicity" EXACT [GOC:mah]
synonym: "upregulation of neutrophil mediated cytotoxicity" EXACT [GOC:mah]
is_a: GO:0001912 ! positive regulation of leukocyte mediated cytotoxicity
is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity
is_a: GO:0070948 ! regulation of neutrophil mediated cytotoxicity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070942 ! neutrophil mediated cytotoxicity
relationship: positively_regulates GO:0070942 ! neutrophil mediated cytotoxicity
created_by: midori
creation_date: 2009-10-01T02:28:49Z

[Term]
id: GO:0070961
name: positive regulation of neutrophil mediated killing of symbiont cell
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the directed killing of a symbiont target cell by a neutrophil." [GOC:add, GOC:mah]
synonym: "activation of neutrophil mediated killing of symbiont cell" NARROW [GOC:mah]
synonym: "stimulation of neutrophil mediated killing of symbiont cell" NARROW [GOC:mah]
synonym: "up regulation of neutrophil mediated killing of symbiont cell" EXACT [GOC:mah]
synonym: "up-regulation of neutrophil mediated killing of symbiont cell" EXACT [GOC:mah]
synonym: "upregulation of neutrophil mediated killing of symbiont cell" EXACT [GOC:mah]
is_a: GO:0002833 ! positive regulation of response to biotic stimulus
is_a: GO:0031349 ! positive regulation of defense response
is_a: GO:0032103 ! positive regulation of response to external stimulus
is_a: GO:0051712 ! positive regulation of killing of cells of other organism
is_a: GO:0070949 ! regulation of neutrophil mediated killing of symbiont cell
is_a: GO:0070960 ! positive regulation of neutrophil mediated cytotoxicity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070943 ! neutrophil mediated killing of symbiont cell
relationship: positively_regulates GO:0070943 ! neutrophil mediated killing of symbiont cell
created_by: midori
creation_date: 2009-10-01T02:28:49Z

[Term]
id: GO:0070962
name: positive regulation of neutrophil mediated killing of bacterium
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the directed killing of a bacterium by a neutrophil." [GOC:add, GOC:mah]
synonym: "activation of neutrophil mediated killing of bacterium" NARROW [GOC:mah]
synonym: "stimulation of neutrophil mediated killing of bacterium" NARROW [GOC:mah]
synonym: "up regulation of neutrophil mediated killing of bacterium" EXACT [GOC:mah]
synonym: "up-regulation of neutrophil mediated killing of bacterium" EXACT [GOC:mah]
synonym: "upregulation of neutrophil mediated killing of bacterium" EXACT [GOC:mah]
is_a: GO:0070950 ! regulation of neutrophil mediated killing of bacterium
is_a: GO:0070961 ! positive regulation of neutrophil mediated killing of symbiont cell
is_a: GO:1900426 ! positive regulation of defense response to bacterium
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070944 ! neutrophil mediated killing of bacterium
relationship: positively_regulates GO:0070944 ! neutrophil mediated killing of bacterium
created_by: midori
creation_date: 2009-10-01T02:28:49Z

[Term]
id: GO:0070963
name: positive regulation of neutrophil mediated killing of gram-negative bacterium
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the directed killing of a gram-negative bacterium by a neutrophil." [GOC:add, GOC:mah]
synonym: "activation of neutrophil mediated killing of gram-negative bacterium" NARROW [GOC:mah]
synonym: "stimulation of neutrophil mediated killing of gram-negative bacterium" NARROW [GOC:mah]
synonym: "up regulation of neutrophil mediated killing of gram-negative bacterium" EXACT [GOC:mah]
synonym: "up-regulation of neutrophil mediated killing of gram-negative bacterium" EXACT [GOC:mah]
synonym: "upregulation of neutrophil mediated killing of gram-negative bacterium" EXACT [GOC:mah]
is_a: GO:0070951 ! regulation of neutrophil mediated killing of gram-negative bacterium
is_a: GO:0070962 ! positive regulation of neutrophil mediated killing of bacterium
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070945 ! neutrophil mediated killing of gram-negative bacterium
relationship: positively_regulates GO:0070945 ! neutrophil mediated killing of gram-negative bacterium
created_by: midori
creation_date: 2009-10-01T02:28:49Z

[Term]
id: GO:0070964
name: positive regulation of neutrophil mediated killing of gram-positive bacterium
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the directed killing of a gram-positive bacterium by a neutrophil." [GOC:add, GOC:mah]
synonym: "activation of neutrophil mediated killing of gram-positive bacterium" NARROW [GOC:mah]
synonym: "stimulation of neutrophil mediated killing of gram-positive bacterium" NARROW [GOC:mah]
synonym: "up regulation of neutrophil mediated killing of gram-positive bacterium" EXACT [GOC:mah]
synonym: "up-regulation of neutrophil mediated killing of gram-positive bacterium" EXACT [GOC:mah]
synonym: "upregulation of neutrophil mediated killing of gram-positive bacterium" EXACT [GOC:mah]
is_a: GO:0070952 ! regulation of neutrophil mediated killing of gram-positive bacterium
is_a: GO:0070962 ! positive regulation of neutrophil mediated killing of bacterium
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070946 ! neutrophil mediated killing of gram-positive bacterium
relationship: positively_regulates GO:0070946 ! neutrophil mediated killing of gram-positive bacterium
created_by: midori
creation_date: 2009-10-01T02:28:49Z

[Term]
id: GO:0070965
name: positive regulation of neutrophil mediated killing of fungus
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the directed killing of a fungal cell by a neutrophil." [GOC:add, GOC:mah]
synonym: "activation of neutrophil mediated killing of fungus" NARROW [GOC:mah]
synonym: "stimulation of neutrophil mediated killing of fungus" NARROW [GOC:mah]
synonym: "up regulation of neutrophil mediated killing of fungus" EXACT [GOC:mah]
synonym: "up-regulation of neutrophil mediated killing of fungus" EXACT [GOC:mah]
synonym: "upregulation of neutrophil mediated killing of fungus" EXACT [GOC:mah]
is_a: GO:0070953 ! regulation of neutrophil mediated killing of fungus
is_a: GO:0070961 ! positive regulation of neutrophil mediated killing of symbiont cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070947 ! neutrophil mediated killing of fungus
relationship: positively_regulates GO:0070947 ! neutrophil mediated killing of fungus
created_by: midori
creation_date: 2009-10-01T02:28:49Z

[Term]
id: GO:0070966
name: nuclear-transcribed mRNA catabolic process, no-go decay
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA with stalls in translation elongation." [GOC:jp, PMID:16554824]
synonym: "no-go decay" EXACT [GOC:jp]
synonym: "no-go mRNA decay" EXACT [GOC:jp]
synonym: "nuclear-transcribed mRNA breakdown, no-go decay" EXACT [GOC:jp]
synonym: "nuclear-transcribed mRNA catabolism, no-go decay" EXACT [GOC:jp]
synonym: "nuclear-transcribed mRNA degradation, no-go decay" EXACT [GOC:jp]
is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process
created_by: midori
creation_date: 2009-10-01T02:36:22Z

[Term]
id: GO:0070967
name: coenzyme F420 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with F420, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [CHEBI:16848, GOC:dh]
is_a: GO:0031406 ! carboxylic acid binding
is_a: GO:0050662 ! coenzyme binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:0097367 ! carbohydrate derivative binding
is_a: GO:1901363 ! heterocyclic compound binding
created_by: midori
creation_date: 2009-10-02T11:33:26Z

[Term]
id: GO:0070968
name: pyrroloquinoline quinone binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with pyrroloquinoline quinone, PQQ, the coenzyme or the prosthetic group of certain alcohol dehydrogenases and glucose dehydrogenases." [CHEBI:18315, GOC:dh]
synonym: "PQQ binding" EXACT [GOC:dh]
is_a: GO:0031406 ! carboxylic acid binding
is_a: GO:0048038 ! quinone binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding
created_by: midori
creation_date: 2009-10-02T11:39:13Z

[Term]
id: GO:0070970
name: interleukin-2 secretion
namespace: biological_process
def: "The regulated release of interleukin-2 from a cell." [GOC:mah, PMID:16930574]
synonym: "IL-2 secretion" EXACT [GOC:mah]
is_a: GO:0050663 ! cytokine secretion
relationship: part_of GO:0032623 ! interleukin-2 production
created_by: midori
creation_date: 2009-10-02T12:03:07Z

[Term]
id: GO:0070971
name: endoplasmic reticulum exit site
namespace: cellular_component
def: "An endoplasmic reticulum part at which COPII-coated vesicles are produced." [NIF_Subcellular:sao124393998, PMID:15623529, PMID:16957052]
synonym: "ER exit site" EXACT [GOC:mah]
synonym: "transitional ER" EXACT [PMID:15623529]
xref: NIF_Subcellular:sao124393998
is_a: GO:0044432 ! endoplasmic reticulum part
created_by: midori
creation_date: 2009-10-02T12:19:23Z

[Term]
id: GO:0070972
name: protein localization to endoplasmic reticulum
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum." [GOC:mah]
synonym: "protein localisation in endoplasmic reticulum" EXACT [GOC:mah]
synonym: "protein localization in endoplasmic reticulum" EXACT [GOC:curators]
synonym: "protein localization in ER" EXACT [GOC:mah]
is_a: GO:0033365 ! protein localization to organelle
created_by: midori
creation_date: 2009-10-02T12:43:34Z

[Term]
id: GO:0070973
name: protein localization to endoplasmic reticulum exit site
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location at an endoplasmic reticulum exit site." [GOC:mah]
synonym: "protein localisation to endoplasmic reticulum exit site" EXACT [GOC:mah]
synonym: "protein localization to ER exit site" EXACT [GOC:mah]
is_a: GO:0070972 ! protein localization to endoplasmic reticulum
created_by: midori
creation_date: 2009-10-02T12:45:41Z

[Term]
id: GO:0070974
name: POU domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a POU domain of a protein. The POU domain is a bipartite DNA binding domain composed of two subunits separated by a non-conserved region of 15-55 amino acids; it is found in several eukaryotic transcription factors." [GOC:mah, GOC:yaf, InterPro:IPR000327]
is_a: GO:0019904 ! protein domain specific binding
created_by: midori
creation_date: 2009-10-02T12:53:02Z

[Term]
id: GO:0070975
name: FHA domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a FHA domain of a protein. The FHA domain is a phosphopeptide recognition domain found in many regulatory proteins, and consists of approximately 80-100 amino acid residues folded into an 11-stranded beta sandwich." [GOC:mah, InterPro:IPR000253]
synonym: "Forkhead-associated domain binding" EXACT [InterPro:IPR000253]
is_a: GO:0019904 ! protein domain specific binding
created_by: midori
creation_date: 2009-10-02T01:09:20Z

[Term]
id: GO:0070976
name: TIR domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a Toll-Interleukin receptor (TIR) domain of a protein. The TIR domain is an intracellular 200 residue domain that is found in the Toll protein, the interleukin-1 receptor (IL-1R), and MyD88; it contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components." [GOC:mah, InterPro:IPR000157]
subset: goslim_chembl
synonym: "Toll-Interleukin receptor domain binding" EXACT [InterPro:IPR000157]
is_a: GO:0019904 ! protein domain specific binding
created_by: midori
creation_date: 2009-10-02T01:17:29Z

[Term]
id: GO:0070977
name: bone maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for bone to attain its fully functional state." [GOC:dph, GOC:mah]
is_a: GO:0048799 ! organ maturation
relationship: part_of GO:0060348 ! bone development
created_by: midori
creation_date: 2009-10-05T04:35:31Z

[Term]
id: GO:0070978
name: voltage-gated calcium channel complex assembly
namespace: biological_process
def: "Cellular protein complex assembly that results in the formation of a voltage-gated calcium channel complex." [GOC:mh]
is_a: GO:0043623 ! cellular protein complex assembly
created_by: midori
creation_date: 2009-10-06T04:51:13Z

[Term]
id: GO:0070979
name: protein K11-linked ubiquitination
namespace: biological_process
def: "A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains." [GOC:jsg, GOC:pr, GOC:sp, PMID:18485873, PMID:20655260, PMID:21113135]
is_a: GO:0000209 ! protein polyubiquitination
created_by: midori
creation_date: 2009-10-26T04:50:57Z

[Term]
id: GO:0070980
name: biphenyl catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of biphenyl, a toxic aromatic hydrocarbon used as a heat transfer agent, as a fungistat in packaging citrus fruits and in plant disease control. Biphenyl can be chlorinated with 1-10 chlorine molecules to form polychlorinated biphenyls (PCBs)." [CHEBI:17097, PMID:16310831, PMID:16339959, UniPathway:UPA00155]
synonym: "biphenyl breakdown" EXACT [GOC:mah]
synonym: "biphenyl catabolism" EXACT [GOC:mah]
synonym: "biphenyl degradation" EXACT [GOC:mah]
is_a: GO:0018879 ! biphenyl metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
created_by: midori
creation_date: 2009-10-27T11:24:59Z

[Term]
id: GO:0070981
name: L-asparagine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of asparagine, (2S)-2-amino-3-carbamoylpropanoic acid." [CHEBI:17196, GOC:mah]
subset: gosubset_prok
synonym: "L-asparagine anabolism" EXACT [GOC:mah]
synonym: "L-asparagine biosynthesis" EXACT [GOC:mah]
synonym: "L-asparagine formation" EXACT [GOC:mah]
synonym: "L-asparagine synthesis" EXACT [GOC:mah]
is_a: GO:0006529 ! asparagine biosynthetic process
is_a: GO:0070982 ! L-asparagine metabolic process
created_by: midori
creation_date: 2009-10-27T12:59:42Z

[Term]
id: GO:0070982
name: L-asparagine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving L-asparagine, (2S)-2-amino-3-carbamoylpropanoic acid." [CHEBI:17196, GOC:mah]
subset: gosubset_prok
synonym: "L-asparagine metabolism" EXACT [GOC:mah]
is_a: GO:0006528 ! asparagine metabolic process
created_by: midori
creation_date: 2009-10-27T01:03:46Z

[Term]
id: GO:0070983
name: dendrite guidance
namespace: biological_process
def: "The process in which the migration of a dendrite is directed to a specific target site in response to a combination of attractive and repulsive cues." [GOC:sart, PMID:15046878]
synonym: "dendritic guidance" EXACT [GOC:sart]
is_a: GO:0097485 ! neuron projection guidance
relationship: part_of GO:0048813 ! dendrite morphogenesis
created_by: midori
creation_date: 2009-10-27T03:53:23Z

[Term]
id: GO:0070984
name: SET domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a SET domain of a protein. SET domains are named after three Drosophila proteins that contain this domain: Su(var), E(z) and trithorax. SET domains are associated with histone lysine methylation." [GOC:sart, Pfam:PF00856, PMID:12575990]
synonym: "SET binding" EXACT [GOC:sart]
is_a: GO:0019904 ! protein domain specific binding
created_by: midori
creation_date: 2009-10-27T04:09:28Z

[Term]
id: GO:0070985
name: TFIIK complex
namespace: cellular_component
def: "A transcription factor complex that forms part of the holo TFIIH complex. In Saccharomyces/human, TFIIK contains Ccl1p/Cyclin H, Tfb3p/MAT1 and Kin2p/CDK7." [GOC:mah, PMID:19818408, PMID:22572993]
synonym: "cyclin H-CDK7 complex" RELATED []
synonym: "Mcs6/Mcs2/Pmh1 complex" NARROW [GOC:vw, PMID:19328067]
is_a: GO:0044451 ! nucleoplasm part
is_a: GO:0090575 ! RNA polymerase II transcription factor complex
relationship: part_of GO:0005675 ! holo TFIIH complex
created_by: midori
creation_date: 2009-10-27T04:19:37Z

[Term]
id: GO:0070986
name: left/right axis specification
namespace: biological_process
def: "The establishment, maintenance and elaboration of the left/right axis. The left/right axis is defined by a line that runs orthogonal to both the anterior/posterior and dorsal/ventral axes. Each side is defined from the viewpoint of the organism rather of the observer (as per anatomical axes)." [GOC:dph, GOC:gvg, GOC:mah]
synonym: "left-right axis specification" EXACT [GOC:mah]
synonym: "left/right axis determination" RELATED [GOC:dph]
is_a: GO:0009798 ! axis specification
relationship: part_of GO:0060972 ! left/right pattern formation
created_by: midori
creation_date: 2009-10-29T01:43:34Z

[Term]
id: GO:0070987
name: error-free translesion synthesis
namespace: biological_process
def: "The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions but does not causes an increase in the endogenous mutation level. For S. cerevisiae, RAD30 encodes DNA polymerase eta, which incorporates two adenines. When incorporated across a thymine-thymine dimer, it does not increase the endogenous mutation level." [GOC:elh]
comment: Note that 'error-free' does not mean that literally zero errors occur during DNA synthesis, but that the error rate is low, comparable to that of DNA synthesis during replication.
subset: gosubset_prok
is_a: GO:0019985 ! translesion synthesis
created_by: midori
creation_date: 2009-10-29T02:45:42Z

[Term]
id: GO:0070988
name: demethylation
namespace: biological_process
def: "The process of removing one or more methyl groups from a molecule." [GOC:BHF, GOC:rl]
is_a: GO:0044710 ! single-organism metabolic process
created_by: midori
creation_date: 2009-10-29T03:12:51Z

[Term]
id: GO:0070989
name: oxidative demethylation
namespace: biological_process
def: "The process of removing one or more methyl groups from a molecule, involving the oxidation (i.e. electron loss) of one or more atoms in the substrate." [GOC:BHF, GOC:mah, GOC:rl]
subset: goslim_chembl
is_a: GO:0055114 ! oxidation-reduction process
is_a: GO:0070988 ! demethylation
created_by: midori
creation_date: 2009-10-29T03:33:25Z

[Term]
id: GO:0070990
name: snRNP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any part of a small nuclear ribonucleoprotein particle." [GOC:BHF, GOC:mah, GOC:rl]
is_a: GO:0043021 ! ribonucleoprotein complex binding
created_by: midori
creation_date: 2009-10-29T03:54:25Z

[Term]
id: GO:0070991
name: medium-chain-acyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a medium-chain fatty acid residue. A medium chain fatty acid is any fatty acid with a chain length of between C6 and C12." [CHEBI:59554, GOC:BHF, GOC:mah]
synonym: "MCAD activity" EXACT [GOC:mah]
xref: EC:1.3.99.-
is_a: GO:0003995 ! acyl-CoA dehydrogenase activity
created_by: midori
creation_date: 2009-10-29T04:11:49Z

[Term]
id: GO:0070992
name: translation initiation complex
namespace: cellular_component
def: "A ribonucleoprotein complex that contains a ribosome, mRNA, and initiator tRNA; the functional ribosome is at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site." [GOC:hjd, GOC:mah]
is_a: GO:0030529 ! intracellular ribonucleoprotein complex
is_a: GO:0044444 ! cytoplasmic part
created_by: midori
creation_date: 2009-10-30T01:23:52Z

[Term]
id: GO:0070993
name: translation preinitiation complex
namespace: cellular_component
def: "A ribonucleoprotein complex that contains the small ribosomal subunit, a translation initiation ternary complex (i.e. an initiator tRNA, GTP, and an IF2 or eIF2 complex), and an mRNA." [GOC:hjd, GOC:mah]
is_a: GO:0030529 ! intracellular ribonucleoprotein complex
is_a: GO:0044444 ! cytoplasmic part
created_by: midori
creation_date: 2009-10-30T01:25:00Z

[Term]
id: GO:0070994
name: detection of oxidative stress
namespace: biological_process
def: "The series of events in which a stimulus indicating oxidative stress is received and converted into a molecular signal." [GOC:mah]
is_a: GO:0006979 ! response to oxidative stress
created_by: midori
creation_date: 2009-10-30T02:54:35Z

[Term]
id: GO:0070995
name: NADPH oxidation
namespace: biological_process
def: "A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADPH, to the oxidized form, NADP." [GOC:BHF, GOC:mah]
synonym: "NADP (reduced) dehydrogenation" EXACT [GOC:mah]
synonym: "NADP (reduced) oxidation" EXACT [GOC:mah]
synonym: "NADPH dehydrogenation" EXACT [GOC:mah]
synonym: "reduced NADP dehydrogenation" EXACT [GOC:mah]
synonym: "reduced NADP oxidation" EXACT [GOC:mah]
synonym: "reduced nicotinamide adenine dinucleotide phosphate dehydrogenation" EXACT [GOC:mah]
synonym: "reduced nicotinamide adenine dinucleotide phosphate oxidation" EXACT [GOC:mah]
is_a: GO:0006739 ! NADP metabolic process
is_a: GO:0055114 ! oxidation-reduction process
created_by: midori
creation_date: 2009-11-03T12:02:15Z

[Term]
id: GO:0070996
name: type 1 melanocortin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 1 melanocortin receptor." [GOC:BHF, GOC:mah]
synonym: "type 1 melanocortin receptor ligand" NARROW [GOC:mah]
is_a: GO:0031779 ! melanocortin receptor binding
created_by: midori
creation_date: 2009-11-03T01:50:53Z

[Term]
id: GO:0070997
name: neuron death
namespace: biological_process
def: "The process of cell death in a neuron." [GOC:BHF, GOC:mah]
comment: This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide or use of neuron-specific markers) show that neuron death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the neuron death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'), and the cell type captured as an annotation extension; or the term GO:0051402 'neuron apoptotic process' may be considered, if appropriate.
synonym: "neuron cell death" EXACT [GOC:mah, GOC:rl]
synonym: "neuronal cell death" EXACT [GOC:mah]
is_a: GO:0008219 ! cell death
created_by: midori
creation_date: 2009-11-03T02:37:17Z

[Term]
id: GO:0070998
name: sensory perception of gravity
namespace: biological_process
def: "The series of events required for an organism to receive a gravitational stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:mah]
is_a: GO:0007600 ! sensory perception
created_by: midori
creation_date: 2009-11-03T03:25:12Z

[Term]
id: GO:0070999
name: detection of mechanical stimulus involved in sensory perception of gravity
namespace: biological_process
def: "The series of events involved in the perception of gravity in which a sensory mechanical stimulus is received and converted into a molecular signal." [GOC:dos, GOC:mah]
is_a: GO:0009590 ! detection of gravity
is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception
intersection_of: GO:0050982 ! detection of mechanical stimulus
intersection_of: part_of GO:0070998 ! sensory perception of gravity
relationship: part_of GO:0070998 ! sensory perception of gravity
created_by: midori
creation_date: 2009-11-03T03:27:30Z

[Term]
id: GO:0071000
name: response to magnetism
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnetic stimulus." [GOC:sl]
synonym: "response to magnetic stimulus" EXACT [GOC:mah]
is_a: GO:0009628 ! response to abiotic stimulus
created_by: midori
creation_date: 2009-11-04T12:02:03Z

[Term]
id: GO:0071001
name: U4/U6 snRNP
namespace: cellular_component
def: "A ribonucleoprotein complex that contains base-paired U4 and U6 small nuclear RNAs." [GOC:mah, PMID:14685174]
is_a: GO:0097525 ! spliceosomal snRNP complex
relationship: has_part GO:0005687 ! U4 snRNP
relationship: has_part GO:0005688 ! U6 snRNP
created_by: midori
creation_date: 2009-07-30T12:00:35Z

[Term]
id: GO:0071002
name: U4atac/U6atac snRNP
namespace: cellular_component
def: "A ribonucleoprotein complex that contains base-paired U4atac and U6atac small nuclear RNAs." [GOC:mah, PMID:14685174]
is_a: GO:0097525 ! spliceosomal snRNP complex
relationship: has_part GO:0005690 ! U4atac snRNP
relationship: has_part GO:0005691 ! U6atac snRNP
created_by: midori
creation_date: 2009-07-30T12:00:35Z

[Term]
id: GO:0071003
name: penta-snRNP complex
namespace: cellular_component
def: "A ribonucleoprotein complex formed by the association of the U1, U2, U4/U6 and U5 small nuclear ribonucleoproteins." [GOC:mah, PMID:11804584, PMID:12724403]
synonym: "penta-RNP complex" EXACT [GOC:rb]
is_a: GO:0097525 ! spliceosomal snRNP complex
relationship: has_part GO:0005682 ! U5 snRNP
relationship: has_part GO:0005685 ! U1 snRNP
relationship: has_part GO:0005686 ! U2 snRNP
relationship: has_part GO:0071001 ! U4/U6 snRNP
created_by: midori
creation_date: 2009-07-30T12:00:35Z

[Term]
id: GO:0071004
name: U2-type prespliceosome
namespace: cellular_component
def: "A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation." [GOC:ab, GOC:krc, GOC:mah, PMID:17332742, PMID:19239890]
synonym: "GT-AG prespliceosome" NARROW [GOC:krc, GOC:mah]
synonym: "major prespliceosome" EXACT [GOC:krc, GOC:mah]
synonym: "mammalian U2-type spliceosomal complex A" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890]
synonym: "yeast U2-type spliceosomal complex B" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
is_a: GO:0005684 ! U2-type spliceosomal complex
is_a: GO:0071010 ! prespliceosome
relationship: has_part GO:0005685 ! U1 snRNP
relationship: has_part GO:0005686 ! U2 snRNP
created_by: midori
creation_date: 2009-07-30T12:00:35Z

[Term]
id: GO:0071005
name: U2-type precatalytic spliceosome
namespace: cellular_component
def: "A spliceosomal complex that is formed by the recruitment of the preassembled U4/U6.U5 tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U1, U2 and U4/U6.U5 snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
synonym: "GT-AG precatalytic spliceosome" NARROW [GOC:krc, GOC:mah]
synonym: "major precatalytic spliceosome" EXACT [GOC:krc, GOC:mah]
synonym: "mammalian U2-type spliceosomal complex B" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890]
synonym: "mammalian U2-type spliceosomal complex B1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "yeast U12-type spliceosomal complex A2-1" RELATED [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
is_a: GO:0005684 ! U2-type spliceosomal complex
is_a: GO:0071011 ! precatalytic spliceosome
relationship: has_part GO:0005685 ! U1 snRNP
relationship: has_part GO:0005686 ! U2 snRNP
relationship: has_part GO:0046540 ! U4/U6 x U5 tri-snRNP complex
created_by: midori
creation_date: 2009-07-30T12:00:35Z

[Term]
id: GO:0071006
name: U2-type catalytic step 1 spliceosome
namespace: cellular_component
def: "A spliceosomal complex that is formed by the displacement of the U1 and U4 snRNPs from the precatalytic spliceosome; the U2, U5 and U6 snRNPs remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the U2, and U5 and U6 snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
synonym: "GT-AG catalytic step 1 spliceosome" NARROW [GOC:krc, GOC:mah]
synonym: "major catalytic step 1 spliceosome" EXACT [GOC:krc, GOC:mah]
synonym: "mammalian U2-type spliceosomal complex B*" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890]
synonym: "mammalian U2-type spliceosomal complex B2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "U2-type activated spliceosome" EXACT [GOC:krc, ISBN:0879695897, ISBN:0879697393]
synonym: "yeast U2-type spliceosomal complex A1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
is_a: GO:0005684 ! U2-type spliceosomal complex
is_a: GO:0071012 ! catalytic step 1 spliceosome
relationship: has_part GO:0005686 ! U2 snRNP
relationship: has_part GO:0005688 ! U6 snRNP
created_by: midori
creation_date: 2009-07-30T12:00:35Z

[Term]
id: GO:0071007
name: U2-type catalytic step 2 spliceosome
namespace: cellular_component
def: "A spliceosomal complex that contains the U2, U5 and U6 snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U2, U5 and U6 snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
synonym: "GT-AG catalytic step 2 spliceosome" NARROW [GOC:krc, GOC:mah]
synonym: "major catalytic step 2 spliceosome" EXACT [GOC:krc, GOC:mah]
synonym: "mammalian U2-type spliceosomal complex C" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890]
synonym: "mammalian U2-type spliceosomal complex C1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "yeast U2-type spliceosomal complex A2-2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
is_a: GO:0005684 ! U2-type spliceosomal complex
is_a: GO:0071013 ! catalytic step 2 spliceosome
relationship: has_part GO:0005686 ! U2 snRNP
relationship: has_part GO:0005688 ! U6 snRNP
created_by: midori
creation_date: 2009-07-30T12:00:35Z

[Term]
id: GO:0071008
name: U2-type post-mRNA release spliceosomal complex
namespace: cellular_component
def: "A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and the U2, U5 and U6 snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890]
synonym: "GT-AG post-mRNA release spliceosomal complex" NARROW [GOC:krc, GOC:mah]
synonym: "major post-mRNA release spliceosomal complex" EXACT [GOC:krc, GOC:mah]
synonym: "mammalian U2-type spliceosomal complex I" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "U2/U5/U6 snRNP complex" EXACT [GOC:mah, PMID:12374752, PMID:20400941, PMID:24442611]
synonym: "U2/U5/U6 tri-snRNP complex" EXACT [GOC:mah, PMID:12374752, PMID:20400941]
is_a: GO:0005684 ! U2-type spliceosomal complex
is_a: GO:0071014 ! post-mRNA release spliceosomal complex
relationship: has_part GO:0005686 ! U2 snRNP
relationship: has_part GO:0005688 ! U6 snRNP
created_by: midori
creation_date: 2009-07-30T12:00:35Z

[Term]
id: GO:0071009
name: U4atac/U6atac x U5 tri-snRNP complex
namespace: cellular_component
def: "A ribonucleoprotein complex formed by the association of the U4atac/U6atac and U5 small nuclear ribonucleoproteins." [GOC:krc, GOC:mah, GOC:pr, PMID:16201866]
synonym: "U4atac/U6atac.U5 snRNP complex" EXACT []
is_a: GO:0097526 ! spliceosomal tri-snRNP complex
relationship: has_part GO:0005682 ! U5 snRNP
relationship: has_part GO:0071002 ! U4atac/U6atac snRNP
created_by: midori
creation_date: 2009-07-30T12:00:35Z

[Term]
id: GO:0071010
name: prespliceosome
namespace: cellular_component
def: "A spliceosomal complex that is formed by association of the 5' splice site and the branch point sequence with specific snRNPs. The prespliceosome includes many proteins in addition to those found in the bound snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation. Prespliceosome complexes are not active for splicing, but are instead an early step in the assembly of a spliceosomal complex." [GOC:ab, GOC:krc, GOC:mah, PMID:17332742, PMID:19239890]
synonym: "mammalian spliceosomal complex A" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890]
synonym: "prespliceosomal complex" EXACT [GOC:vw]
synonym: "yeast spliceosomal complex B" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
is_a: GO:0005681 ! spliceosomal complex
created_by: midori
creation_date: 2009-07-30T12:00:35Z

[Term]
id: GO:0071011
name: precatalytic spliceosome
namespace: cellular_component
def: "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
synonym: "mammalian spliceosomal complex B" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890]
synonym: "mammalian spliceosomal complex B1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "yeast spliceosomal complex A2-1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
is_a: GO:0005681 ! spliceosomal complex
created_by: midori
creation_date: 2009-07-30T12:00:35Z

[Term]
id: GO:0071012
name: catalytic step 1 spliceosome
namespace: cellular_component
def: "A spliceosomal complex that is formed by the displacement of the two snRNPs from the precatalytic spliceosome; three snRNPs including U5 remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
synonym: "activated spliceosome" EXACT [GOC:krc, ISBN:0879695897, ISBN:0879697393]
synonym: "mammalian spliceosomal complex B*" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890]
synonym: "mammalian spliceosomal complex B2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "yeast spliceosomal complex A1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
is_a: GO:0005681 ! spliceosomal complex
relationship: has_part GO:0000974 ! Prp19 complex
relationship: has_part GO:0005682 ! U5 snRNP
created_by: midori
creation_date: 2009-07-30T12:00:35Z

[Term]
id: GO:0071013
name: catalytic step 2 spliceosome
namespace: cellular_component
def: "A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
synonym: "mammalian spliceosomal complex C" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890]
synonym: "mammalian spliceosomal complex C1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "yeast spliceosomal complex A2-2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
is_a: GO:0005681 ! spliceosomal complex
relationship: has_part GO:0000974 ! Prp19 complex
relationship: has_part GO:0005682 ! U5 snRNP
created_by: midori
creation_date: 2009-07-30T12:00:35Z

[Term]
id: GO:0071014
name: post-mRNA release spliceosomal complex
namespace: cellular_component
def: "A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and three snRNPs, including U5." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890]
synonym: "mammalian spliceosomal complex I" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
is_a: GO:0005681 ! spliceosomal complex
relationship: has_part GO:0005682 ! U5 snRNP
created_by: midori
creation_date: 2009-07-30T12:00:35Z

[Term]
id: GO:0071015
name: U12-type prespliceosome
namespace: cellular_component
def: "A spliceosomal complex that is formed by the cooperative binding of the heterodimeric U11/U12 snRNP to the 5' splice site and the branch point sequence. The U12-type prespliceosome includes many proteins in addition to those found in the U11/U12 heterodimeric snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation." [GOC:ab, GOC:krc, GOC:mah, PMID:10197985, PMID:16201866]
synonym: "AT-AC prespliceosome" NARROW [GOC:krc, GOC:mah]
synonym: "mammalian U12-type spliceosomal complex A" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890]
synonym: "minor prespliceosome" EXACT [GOC:krc, GOC:mah]
synonym: "yeast U12-type spliceosomal complex B" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
is_a: GO:0005689 ! U12-type spliceosomal complex
is_a: GO:0071010 ! prespliceosome
relationship: has_part GO:0034693 ! U11/U12 snRNP
created_by: midori
creation_date: 2009-07-30T12:00:35Z

[Term]
id: GO:0071016
name: U12-type precatalytic spliceosome
namespace: cellular_component
def: "A spliceosomal complex that is formed by the recruitment of the preassembled U4atac/U6atac.U5 tri-snRNP to the U12-type prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U11, U12 and U4atac/U6atac.U5 snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:16201866]
synonym: "AT-AC precatalytic spliceosome" NARROW [GOC:krc, GOC:mah]
synonym: "mammalian U12-type spliceosomal complex B" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890]
synonym: "mammalian U12-type spliceosomal complex B1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "minor precatalytic spliceosome" EXACT [GOC:krc, GOC:mah]
synonym: "yeast U12-type spliceosomal complex A2-1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
is_a: GO:0005689 ! U12-type spliceosomal complex
is_a: GO:0071011 ! precatalytic spliceosome
relationship: has_part GO:0005692 ! U11 snRNP
relationship: has_part GO:0005693 ! U12 snRNP
relationship: has_part GO:0071009 ! U4atac/U6atac x U5 tri-snRNP complex
created_by: midori
creation_date: 2009-07-30T12:00:35Z

[Term]
id: GO:0071017
name: U12-type catalytic step 1 spliceosome
namespace: cellular_component
def: "A spliceosomal complex that is formed by the displacement of the U11 and U4atac snRNPs from the precatalytic spliceosome; the U12, U5 and U6atac snRNPs remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the U12, and U5 and U6atac snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:16201866]
synonym: "AT-AC catalytic step 1 spliceosome" NARROW [GOC:krc, GOC:mah]
synonym: "mammalian U12-type spliceosomal complex B*" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890]
synonym: "mammalian U12-type spliceosomal complex B2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "minor catalytic step 1 spliceosome" EXACT [GOC:krc, GOC:mah]
synonym: "U12-type activated spliceosome" EXACT [GOC:krc, ISBN:0879695897, ISBN:0879697393]
synonym: "yeast U12-type spliceosomal complex A1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
is_a: GO:0005689 ! U12-type spliceosomal complex
is_a: GO:0071012 ! catalytic step 1 spliceosome
relationship: has_part GO:0005691 ! U6atac snRNP
relationship: has_part GO:0005693 ! U12 snRNP
created_by: midori
creation_date: 2009-07-30T12:00:35Z

[Term]
id: GO:0071018
name: U12-type catalytic step 2 spliceosome
namespace: cellular_component
def: "A spliceosomal complex that contains the U12, U5 and U6atac snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U12, U5 and U6atac snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:16201866]
synonym: "AT-AC catalytic step 2 spliceosome" NARROW [GOC:krc, GOC:mah]
synonym: "mammalian U12-type spliceosomal complex C" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890]
synonym: "mammalian U12-type spliceosomal complex C1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "minor catalytic step 2 spliceosome" EXACT [GOC:krc, GOC:mah]
synonym: "yeast U12-type spliceosomal complex A2-2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
is_a: GO:0005689 ! U12-type spliceosomal complex
is_a: GO:0071013 ! catalytic step 2 spliceosome
relationship: has_part GO:0005691 ! U6atac snRNP
relationship: has_part GO:0005693 ! U12 snRNP
created_by: midori
creation_date: 2009-07-30T12:00:35Z

[Term]
id: GO:0071019
name: U12-type post-mRNA release spliceosomal complex
namespace: cellular_component
def: "A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and the U12, U5 and U6atac snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:16201866]
synonym: "AT-AC post-mRNA release spliceosomal complex" NARROW [GOC:krc, GOC:mah]
synonym: "mammalian U12-type spliceosomal complex I" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "minor post-mRNA release spliceosomal complex" EXACT [GOC:krc, GOC:mah]
is_a: GO:0005689 ! U12-type spliceosomal complex
is_a: GO:0005691 ! U6atac snRNP
is_a: GO:0005693 ! U12 snRNP
is_a: GO:0071014 ! post-mRNA release spliceosomal complex
created_by: midori
creation_date: 2009-07-30T12:00:35Z

[Term]
id: GO:0071020
name: post-spliceosomal complex
namespace: cellular_component
def: "A spliceosomal complex that is formed following the second splicing event and contains the spliced product, the excised intron, and three snRNPs, including U5." [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "mammalian spliceosomal complex C2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "yeast spliceosomal complex A2-3" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
is_a: GO:0005681 ! spliceosomal complex
relationship: has_part GO:0005682 ! U5 snRNP
created_by: midori
creation_date: 2009-07-30T12:00:35Z

[Term]
id: GO:0071021
name: U2-type post-spliceosomal complex
namespace: cellular_component
def: "A spliceosomal complex that is formed following the second splicing event and contains the spliced product, the excised intron, and three snRNPs, including U5." [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "GT-AG post-spliceosomal complex" NARROW [GOC:krc, GOC:mah]
synonym: "major post-spliceosomal complex" EXACT [GOC:krc, GOC:mah]
synonym: "mammalian U2-type spliceosomal complex C2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "yeast U2-type spliceosomal complex A2-3" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
is_a: GO:0005684 ! U2-type spliceosomal complex
is_a: GO:0071020 ! post-spliceosomal complex
relationship: has_part GO:0005686 ! U2 snRNP
relationship: has_part GO:0005688 ! U6 snRNP
created_by: midori
creation_date: 2009-07-30T12:00:35Z

[Term]
id: GO:0071022
name: U12-type post-spliceosomal complex
namespace: cellular_component
def: "A spliceosomal complex that is formed following the second splicing event and contains the spliced product, the excised intron, and three snRNPs, including U5." [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "AT-AC post-spliceosomal complex" NARROW [GOC:krc, GOC:mah]
synonym: "mammalian U12-type spliceosomal complex C2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "minor post-spliceosomal complex" EXACT [GOC:krc, GOC:mah]
synonym: "yeast U12-type spliceosomal complex A2-3" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
is_a: GO:0005689 ! U12-type spliceosomal complex
is_a: GO:0071020 ! post-spliceosomal complex
relationship: has_part GO:0005691 ! U6atac snRNP
relationship: has_part GO:0005693 ! U12 snRNP
created_by: midori
creation_date: 2009-07-30T12:00:35Z

[Term]
id: GO:0071023
name: trans spliceosomal complex
namespace: cellular_component
def: "A spliceosomal complex that forms during the addition of a specific spliced leader (SL) sequence to the 5'-end of a messenger RNA primary transcript, a process which occurs in a number of eukaryotic organisms, including trypanosomatid protozoans, euglenoids, nematodes, trematodes, and chordates." [GOC:krc, ISBN:0879697393]
is_a: GO:0005681 ! spliceosomal complex
relationship: has_part GO:0005682 ! U5 snRNP
relationship: has_part GO:0005686 ! U2 snRNP
relationship: has_part GO:0005687 ! U4 snRNP
relationship: has_part GO:0005688 ! U6 snRNP
relationship: has_part GO:0071024 ! SL snRNP
created_by: midori
creation_date: 2009-07-30T12:00:35Z

[Term]
id: GO:0071024
name: SL snRNP
namespace: cellular_component
def: "A ribonucleoprotein complex that contains spliced leader (SL) RNA." [GOC:krc, ISBN:0879697393]
is_a: GO:0097525 ! spliceosomal snRNP complex
created_by: midori
creation_date: 2009-07-30T12:00:35Z

[Term]
id: GO:0071025
name: RNA surveillance
namespace: biological_process
def: "The set of processes involved in identifying and degrading defective or aberrant RNAs." [GOC:dgf, GOC:krc, PMID:18644474]
synonym: "aberrant RNA catabolic process" EXACT [GOC:dgf, GOC:krc]
synonym: "RNA quality control" EXACT [GOC:dgf, GOC:krc]
is_a: GO:0006401 ! RNA catabolic process
created_by: kchris
creation_date: 2009-07-28T03:10:28Z

[Term]
id: GO:0071026
name: cytoplasmic RNA surveillance
namespace: biological_process
def: "The set of processes involved in identifying and degrading defective or aberrant RNAs within the cytoplasm." [GOC:dgf, GOC:krc, PMID:18644474]
synonym: "cytoplasmic aberrant RNA catabolic process" EXACT [GOC:dgf, GOC:krc]
synonym: "cytoplasmic RNA quality control" EXACT [GOC:dgf, GOC:krc]
is_a: GO:0071025 ! RNA surveillance
intersection_of: GO:0071025 ! RNA surveillance
intersection_of: occurs_in GO:0005737 ! cytoplasm
relationship: occurs_in GO:0005737 ! cytoplasm
created_by: kchris
creation_date: 2009-07-28T03:14:03Z

[Term]
id: GO:0071027
name: nuclear RNA surveillance
namespace: biological_process
def: "The set of processes involved in identifying and degrading defective or aberrant RNAs within the nucleus." [GOC:dgf, GOC:krc, PMID:18644474]
synonym: "nuclear aberrant RNA catabolic process" EXACT [GOC:dgf, GOC:krc]
synonym: "nuclear RNA quality control" EXACT [GOC:dgf, GOC:krc]
is_a: GO:0071025 ! RNA surveillance
intersection_of: GO:0071025 ! RNA surveillance
intersection_of: occurs_in GO:0005634 ! nucleus
relationship: occurs_in GO:0005634 ! nucleus
created_by: kchris
creation_date: 2009-07-28T03:45:02Z

[Term]
id: GO:0071028
name: nuclear mRNA surveillance
namespace: biological_process
def: "The set of processes involved in identifying and degrading defective or aberrant mRNAs within the nucleus." [GOC:dgf, GOC:krc, PMID:18644474]
synonym: "nuclear aberrant mRNA catabolic process" EXACT [GOC:dgf, GOC:krc]
synonym: "nuclear mRNA quality control" EXACT [GOC:dgf, GOC:krc]
is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process
is_a: GO:0071027 ! nuclear RNA surveillance
created_by: kchris
creation_date: 2009-07-28T04:14:29Z

[Term]
id: GO:0071029
name: nuclear ncRNA surveillance
namespace: biological_process
def: "The set of processes involved in identifying and degrading defective or aberrant ncRNAs within the nucleus." [GOC:dgf, GOC:krc, PMID:18644474]
synonym: "nuclear aberrant ncRNA catabolic process" EXACT [GOC:dgf, GOC:krc]
synonym: "nuclear ncRNA quality control" EXACT [GOC:dgf, GOC:krc]
is_a: GO:0034661 ! ncRNA catabolic process
is_a: GO:0071027 ! nuclear RNA surveillance
created_by: kchris
creation_date: 2009-07-28T04:22:31Z

[Term]
id: GO:0071030
name: nuclear mRNA surveillance of spliceosomal pre-mRNA splicing
namespace: biological_process
def: "The set of processes involved in identifying and degrading incorrectly spliced pre-mRNAs within the nucleus." [GOC:dgf, GOC:krc, PMID:18644474]
synonym: "nuclear mRNA quality control of incorrectly spliced pre-mRNA" EXACT [GOC:dgf, GOC:krc]
synonym: "nuclear RNA catabolic process of incorrectly spliced pre-mRNA" EXACT [GOC:dgf, GOC:krc]
is_a: GO:0071028 ! nuclear mRNA surveillance
relationship: has_part GO:0071042 ! nuclear polyadenylation-dependent mRNA catabolic process
created_by: kchris
creation_date: 2009-07-28T04:24:04Z

[Term]
id: GO:0071031
name: nuclear mRNA surveillance of mRNA 3'-end processing
namespace: biological_process
def: "The set of processes involved in identifying and degrading mRNAs with incorrectly formed 3'-ends within the nucleus." [GOC:dgf, GOC:krc, PMID:18644474]
synonym: "nuclear mRNA catabolic process of mRNA with aberrant 3'-ends" EXACT [GOC:dgf, GOC:krc]
synonym: "nuclear mRNA quality control of mRNAs with aberrant 3'-ends" EXACT [GOC:dgf, GOC:krc]
is_a: GO:0071028 ! nuclear mRNA surveillance
relationship: has_part GO:0071042 ! nuclear polyadenylation-dependent mRNA catabolic process
created_by: kchris
creation_date: 2009-07-28T04:29:17Z

[Term]
id: GO:0071032
name: nuclear mRNA surveillance of mRNP export
namespace: biological_process
def: "The set of processes involved in identifying and degrading incorrectly formed or aberrant nuclear mRNPs docked at the nuclear pore complex prior to export to the cytoplasm." [GOC:dgf, GOC:krc, PMID:18644474]
synonym: "nuclear mRNA catabolic process of mRNAs in aberrant mRNPs" EXACT [GOC:dgf, GOC:krc]
synonym: "nuclear mRNA quality control of mRNAs in aberrant mRNPs" EXACT [GOC:dgf, GOC:krc]
is_a: GO:0071028 ! nuclear mRNA surveillance
created_by: kchris
creation_date: 2009-07-28T04:31:57Z

[Term]
id: GO:0071033
name: nuclear retention of pre-mRNA at the site of transcription
namespace: biological_process
def: "The process involved in retention of aberrant or improperly formed mRNAs, e.g. those that are incorrectly or incompletely spliced or that have incorrectly formed 3'-ends, within the nucleus at the site of transcription." [GOC:dgf, GOC:krc, PMID:11586364, PMID:12417728, PMID:14718167, PMID:18644474]
is_a: GO:0008298 ! intracellular mRNA localization
relationship: occurs_in GO:0005634 ! nucleus
relationship: part_of GO:0071028 ! nuclear mRNA surveillance
created_by: kchris
creation_date: 2009-07-28T04:35:54Z

[Term]
id: GO:0071034
name: CUT catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cryptic unstable transcripts (CUTs)." [GOC:dgf, GOC:krc]
synonym: "cryptic unstable transcript catabolic process" EXACT [GOC:dgf, GOC:krc]
is_a: GO:0034661 ! ncRNA catabolic process
is_a: GO:0071043 ! CUT metabolic process
created_by: kchris
creation_date: 2009-07-29T12:38:04Z

[Term]
id: GO:0071035
name: nuclear polyadenylation-dependent rRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a ribosomal RNA (rRNA) molecule, including RNA fragments released as part of processing the primary transcript into multiple mature rRNA species, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target rRNA." [GOC:dgf, GOC:krc, PMID:15173578, PMID:15572680, PMID:15935758, PMID:17652137, PMID:18591258]
synonym: "nuclear poly(A)-dependent rRNA catabolic process" RELATED [GOC:vw]
is_a: GO:0016075 ! rRNA catabolic process
is_a: GO:0071046 ! nuclear polyadenylation-dependent ncRNA catabolic process
created_by: kchris
creation_date: 2009-07-29T12:42:39Z

[Term]
id: GO:0071036
name: nuclear polyadenylation-dependent snoRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a small nucleolar RNA (snoRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target snoRNA." [GOC:dgf, GOC:krc, PMID:15935758]
synonym: "nuclear poly(A)-dependent snoRNA catabolic process" RELATED [GOC:tb]
is_a: GO:0016077 ! snoRNA catabolic process
is_a: GO:0071046 ! nuclear polyadenylation-dependent ncRNA catabolic process
relationship: has_part GO:0071050 ! snoRNA polyadenylation
created_by: kchris
creation_date: 2009-07-29T01:04:44Z

[Term]
id: GO:0071037
name: nuclear polyadenylation-dependent snRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a small nuclear RNA (snRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target snRNA." [GOC:dgf, GOC:krc]
synonym: "nuclear poly(A)-dependent snRNA catabolic process" RELATED [GOC:vw]
is_a: GO:0016076 ! snRNA catabolic process
is_a: GO:0071046 ! nuclear polyadenylation-dependent ncRNA catabolic process
created_by: kchris
creation_date: 2009-07-29T01:07:18Z

[Term]
id: GO:0071038
name: nuclear polyadenylation-dependent tRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of an aberrant or incorrectly modified transfer RNA (tRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target tRNA." [GOC:dgf, GOC:krc]
synonym: "nuclear poly(A)-dependent tRNA catabolic process" RELATED [GOC:vw]
is_a: GO:0016078 ! tRNA catabolic process
is_a: GO:0071046 ! nuclear polyadenylation-dependent ncRNA catabolic process
created_by: kchris
creation_date: 2009-07-29T01:08:14Z

[Term]
id: GO:0071039
name: nuclear polyadenylation-dependent CUT catabolic process
namespace: biological_process
def: "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a cryptic unstable transcript (CUT), initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target CUT." [GOC:dgf, GOC:krc, PMID:15935759, PMID:16973436, PMID:16973437, PMID:18007593, PMID:18591258]
synonym: "nuclear poly(A)-dependent CUT catabolic process" RELATED [GOC:vw]
is_a: GO:0071034 ! CUT catabolic process
is_a: GO:0071046 ! nuclear polyadenylation-dependent ncRNA catabolic process
created_by: kchris
creation_date: 2009-07-29T01:10:34Z

[Term]
id: GO:0071040
name: nuclear polyadenylation-dependent antisense transcript catabolic process
namespace: biological_process
def: "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of an antisense transcript, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target antisense transcript." [GOC:dgf, GOC:krc, PMID:18022365]
synonym: "nuclear poly(A)-dependent antisense transcript catabolic process" RELATED [GOC:vw]
is_a: GO:0071041 ! antisense RNA transcript catabolic process
is_a: GO:0071046 ! nuclear polyadenylation-dependent ncRNA catabolic process
created_by: kchris
creation_date: 2009-07-29T01:25:21Z

[Term]
id: GO:0071041
name: antisense RNA transcript catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of antisense transcripts, i.e. transcripts that were produced from the antisense strand of a gene that produces a gene product and which often have a regulatory effect on the transcription of that gene product." [GOC:dgf, GOC:krc]
is_a: GO:0034661 ! ncRNA catabolic process
is_a: GO:0042868 ! antisense RNA metabolic process
created_by: kchris
creation_date: 2009-07-29T01:39:36Z

[Term]
id: GO:0071042
name: nuclear polyadenylation-dependent mRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a messenger RNA (mRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target mRNA." [GOC:dgf, GOC:krc, PMID:15145828, PMID:15828860, PMID:16431988, PMID:17643380, PMID:18000032, PMID:18644474]
synonym: "nuclear poly(A)-dependent mRNA catabolic process" RELATED [GOC:vw]
is_a: GO:0071047 ! polyadenylation-dependent mRNA catabolic process
created_by: kchris
creation_date: 2009-07-29T02:06:19Z

[Term]
id: GO:0071043
name: CUT metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cryptic unstable transcripts (CUTs), which are transcribed from intergenic regions. Many intergenic regions are heavily transcribed, but the transcripts are rarely detected due to rapid degradation by the nuclear exosome." [GOC:dgf, GOC:krc, PMID:15935759, PMID:16973436]
is_a: GO:0034660 ! ncRNA metabolic process
created_by: kchris
creation_date: 2009-07-29T02:31:31Z

[Term]
id: GO:0071044
name: histone mRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of histone messenger RNA (mRNA)." [GOC:dgf, GOC:krc, PMID:17179095, PMID:17855393]
is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process
is_a: GO:0008334 ! histone mRNA metabolic process
created_by: kchris
creation_date: 2009-07-30T09:48:10Z

[Term]
id: GO:0071045
name: nuclear histone mRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of histone messenger RNA (mRNA) within the nucleus." [GOC:dgf, GOC:krc, PMID:17179095, PMID:17855393]
is_a: GO:0071044 ! histone mRNA catabolic process
created_by: kchris
creation_date: 2009-07-30T09:52:44Z

[Term]
id: GO:0071046
name: nuclear polyadenylation-dependent ncRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a noncoding RNA (ncRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target ncRNA." [GOC:dgf, GOC:jl, GOC:krc, PMID:17410208]
synonym: "nuclear poly(A)-dependent ncRNA catabolic process" RELATED [GOC:vw]
is_a: GO:0043634 ! polyadenylation-dependent ncRNA catabolic process
is_a: GO:0071029 ! nuclear ncRNA surveillance
created_by: kchris
creation_date: 2009-08-06T02:14:53Z

[Term]
id: GO:0071047
name: polyadenylation-dependent mRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a messenger RNA (mRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target mRNA." [GOC:dgf, GOC:krc]
synonym: "poly(A)-dependent mRNA catabolic process" RELATED [GOC:vw]
is_a: GO:0006402 ! mRNA catabolic process
is_a: GO:0043633 ! polyadenylation-dependent RNA catabolic process
relationship: has_part GO:0006378 ! mRNA polyadenylation
created_by: kchris
creation_date: 2009-08-07T09:57:56Z

[Term]
id: GO:0071048
name: nuclear retention of unspliced pre-mRNA at the site of transcription
namespace: biological_process
def: "The process involved in retention of incorrectly or incompletely spliced pre-mRNA within the nucleus at the site of transcription." [GOC:dgf, GOC:krc, PMID:14718167]
is_a: GO:0071033 ! nuclear retention of pre-mRNA at the site of transcription
relationship: part_of GO:0071030 ! nuclear mRNA surveillance of spliceosomal pre-mRNA splicing
created_by: kchris
creation_date: 2009-08-11T02:19:03Z

[Term]
id: GO:0071049
name: nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription
namespace: biological_process
def: "The process involved in retention of mRNAs that have incorrectly formed 3'-ends within the nucleus at the site of transcription." [GOC:dgf, GOC:krc, PMID:11586364, PMID:12417728]
is_a: GO:0071033 ! nuclear retention of pre-mRNA at the site of transcription
relationship: part_of GO:0071031 ! nuclear mRNA surveillance of mRNA 3'-end processing
created_by: kchris
creation_date: 2009-08-11T02:40:56Z

[Term]
id: GO:0071050
name: snoRNA polyadenylation
namespace: biological_process
def: "The enzymatic addition of a sequence of adenylyl residues at the 3' end of snoRNA molecule. In eukaryotes, this occurs in conjunction with termination of transcription of precursor snoRNA molecules and may occur post-transcriptionally on incorrectly processed molecules targeted for degradation." [GOC:dgf, GOC:krc, PMID:18951092]
is_a: GO:0031126 ! snoRNA 3'-end processing
is_a: GO:0043629 ! ncRNA polyadenylation
created_by: kchris
creation_date: 2009-08-25T03:33:44Z

[Term]
id: GO:0071051
name: polyadenylation-dependent snoRNA 3'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 3' end of a snoRNA molecule linked to prior polyadenylation of the 3'-end of the precursor snoRNA." [GOC:dgf, GOC:krc, PMID:18951092]
synonym: "poly(A)-dependent snoRNA 3'-end processing" RELATED [GOC:vw]
is_a: GO:0031126 ! snoRNA 3'-end processing
relationship: has_part GO:0071050 ! snoRNA polyadenylation
created_by: kchris
creation_date: 2009-08-25T03:47:24Z

[Term]
id: GO:0071052
name: alpha9-beta1 integrin-ADAM1 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM1." [PMID:11882657]
synonym: "ITGA9-ITGB1-ADAM1 complex" NARROW [CORUM:2964]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-03T03:55:15Z

[Term]
id: GO:0071053
name: alpha9-beta1 integrin-ADAM2 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM2." [PMID:11882657]
synonym: "ITGA9-ITGB1-ADAM2 complex" NARROW [CORUM:2441]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-03T03:58:22Z

[Term]
id: GO:0071054
name: alpha9-beta1 integrin-ADAM3 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM3." [PMID:11882657]
synonym: "ITGA9-ITGB1-ADAM3 complex" NARROW [CORUM:2965]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-03T03:59:02Z

[Term]
id: GO:0071055
name: alpha9-beta1 integrin-ADAM9 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM9." [PMID:11882657]
synonym: "ITGA9-ITGB1-ADAM9 complex" NARROW [CORUM:2440]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-03T03:59:24Z

[Term]
id: GO:0071056
name: alpha9-beta1 integrin-ADAM15 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM15." [PMID:11882657]
synonym: "ITGA9-ITGB1-ADAM15 complex" NARROW [CORUM:2445]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-03T03:59:49Z

[Term]
id: GO:0071057
name: alphav-beta3 integrin-ADAM15 complex
namespace: cellular_component
def: "A protein complex that consists of an alphav-beta3 integrin complex bound to the transmembrane metallopeptidase ADAM15." [PMID:10944520, PMID:11882657]
synonym: "ITGAV-ITGB3-ADAM15 complex" NARROW [CORUM:2359]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-03T04:00:14Z

[Term]
id: GO:0071058
name: alpha3-beta1 integrin-CD151 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha3-beta1 integrin complex bound to the tetraspanin CD151." [PMID:10811835, PMID:11884516]
synonym: "ITGA3-ITGB1-CD151 complex" NARROW [CORUM:2400]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-03T04:00:39Z

[Term]
id: GO:0071059
name: alpha6-beta1 integrin-CD151 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha6-beta1 integrin complex bound to the tetraspanin CD151." [PMID:11884516]
synonym: "ITGA6-ITGB1-CD151 complex" NARROW [CORUM:2411]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-03T04:01:23Z

[Term]
id: GO:0071060
name: alpha7-beta1 integrin-CD151 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha7-beta1 integrin complex bound to the tetraspanin CD151." [PMID:11884516]
synonym: "ITGA7-ITGB1-CD151 complex" NARROW [CORUM:2395]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-03T04:02:01Z

[Term]
id: GO:0071061
name: alpha6-beta4 integrin-CD151 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha6-beta4 integrin complex bound to the tetraspanin CD151." [PMID:10811835]
synonym: "ITGA6-ITGB4-CD151 complex" NARROW [CORUM:2320]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-03T04:02:37Z

[Term]
id: GO:0071062
name: alphav-beta3 integrin-vitronectin complex
namespace: cellular_component
def: "A protein complex that consists of an alphav-beta3 integrin complex bound to vitronectin." [PMID:10835423]
synonym: "ITGAV-ITGB3-VTN complex" NARROW [CORUM:2826]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-03T04:02:57Z

[Term]
id: GO:0071063
name: sensory perception of wind
namespace: biological_process
def: "The series of events required for an organism to receive sensory mechanical stimulus resulting from air flow, convert it to a molecular signal, and recognize and characterize the signal." [GOC:mah, PMID:19279637]
synonym: "perception of wind" EXACT [GOC:mah]
synonym: "sensory perception of air flow" EXACT [GOC:mah, PMID:19279637]
is_a: GO:0050954 ! sensory perception of mechanical stimulus
created_by: midori
creation_date: 2009-11-04T02:40:34Z

[Term]
id: GO:0071064
name: alphaE-beta7 integrin-E-cadherin complex
namespace: cellular_component
def: "A protein complex that consists of an alphaE-beta7 integrin complex bound to E-cadherin." [PMID:10837471]
synonym: "ITGAE-ITGB7-CDH1 complex" NARROW [CORUM:1834]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-03T04:03:37Z

[Term]
id: GO:0071065
name: alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular cell adhesion molecule-1." [PMID:10209034]
synonym: "ITGA9-ITGB1-VCAM1 complex" NARROW [CORUM:2442]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-03T04:04:01Z

[Term]
id: GO:0071066
name: detection of mechanical stimulus involved in sensory perception of wind
namespace: biological_process
def: "The series of events involved in the perception of wind in which a mechanical stimulus is received and converted into a molecular signal." [GOC:dos, GOC:mah, PMID:19279637]
synonym: "detection of mechanical stimulus involved in sensory perception of air flow" EXACT [GOC:mah]
synonym: "detection of wind" EXACT [GOC:mah]
synonym: "perception of wind, detection of mechanical stimulus" EXACT [GOC:mah]
synonym: "perception of wind, sensory detection of mechanical stimulus" EXACT [GOC:mah]
synonym: "perception of wind, sensory transduction of mechanical stimulus" EXACT [GOC:mah]
synonym: "sensory detection of mechanical stimulus during perception of wind" EXACT [GOC:mah]
synonym: "sensory transduction of mechanical stimulus during perception of wind" EXACT [GOC:mah]
synonym: "sensory transduction of wind" EXACT [GOC:mah]
is_a: GO:0050877 ! neurological system process
is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception
intersection_of: GO:0050982 ! detection of mechanical stimulus
intersection_of: part_of GO:0071063 ! sensory perception of wind
relationship: part_of GO:0071063 ! sensory perception of wind
created_by: midori
creation_date: 2009-11-04T02:47:36Z

[Term]
id: GO:0071067
name: alphav-beta3 integrin-ADAM23 complex
namespace: cellular_component
def: "A protein complex that consists of an alphav-beta3 integrin complex bound to the transmembrane metallopeptidase ADAM23." [PMID:10749942]
synonym: "ITGAV-ITGB3-ADAM23 complex" NARROW [CORUM:2364]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-03T04:04:40Z

[Term]
id: GO:0071068
name: alpha9-beta1 integrin-ADAM12 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM12." [PMID:10944520]
synonym: "ITGA9-ITGB1-ADAM12 complex" NARROW [CORUM:2447]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-03T04:05:15Z

[Term]
id: GO:0071069
name: alpha4-beta1 integrin-thrombospondin-1 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to thrombospondin-1." [PMID:11980922]
synonym: "ITGA4-ITGB1-THBS1 complex" NARROW [CORUM:2426]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-03T04:05:35Z

[Term]
id: GO:0071070
name: alpha4-beta1 integrin-thrombospondin-2 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to thrombospondin-2." [PMID:11980922]
synonym: "ITGA4-ITGB1-THBS2 complex" NARROW [CORUM:2428]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-03T04:05:56Z

[Term]
id: GO:0071071
name: regulation of phospholipid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phospholipids." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of phospholipid anabolism" EXACT [GOC:mah]
synonym: "regulation of phospholipid biosynthesis" EXACT [GOC:mah]
synonym: "regulation of phospholipid formation" EXACT [GOC:mah]
synonym: "regulation of phospholipid synthesis" EXACT [GOC:mah]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0046890 ! regulation of lipid biosynthetic process
is_a: GO:1903725 ! regulation of phospholipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008654 ! phospholipid biosynthetic process
relationship: regulates GO:0008654 ! phospholipid biosynthetic process
created_by: midori
creation_date: 2009-11-04T03:05:11Z

[Term]
id: GO:0071072
name: negative regulation of phospholipid biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phospholipids." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation of phospholipid biosynthetic process" EXACT [GOC:mah]
synonym: "down-regulation of phospholipid biosynthetic process" EXACT [GOC:ma]
synonym: "downregulation of phospholipid biosynthetic process" EXACT [GOC:mah]
synonym: "inhibition of phospholipid biosynthetic process" NARROW [GOC:mah]
synonym: "negative regulation of phospholipid anabolism" EXACT [GOC:mah]
synonym: "negative regulation of phospholipid biosynthesis" EXACT [GOC:mah]
synonym: "negative regulation of phospholipid formation" EXACT [GOC:mah]
synonym: "negative regulation of phospholipid synthesis" EXACT [GOC:mah]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0051055 ! negative regulation of lipid biosynthetic process
is_a: GO:0071071 ! regulation of phospholipid biosynthetic process
is_a: GO:1903726 ! negative regulation of phospholipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008654 ! phospholipid biosynthetic process
relationship: negatively_regulates GO:0008654 ! phospholipid biosynthetic process
created_by: midori
creation_date: 2009-11-04T03:14:08Z

[Term]
id: GO:0071073
name: positive regulation of phospholipid biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phospholipids." [GOC:mah]
subset: gosubset_prok
synonym: "activation of phospholipid biosynthetic process" NARROW [GOC:mah]
synonym: "positive regulation of phospholipid anabolism" EXACT [GOC:mah]
synonym: "positive regulation of phospholipid biosynthesis" EXACT [GOC:mah]
synonym: "positive regulation of phospholipid formation" EXACT [GOC:mah]
synonym: "positive regulation of phospholipid synthesis" EXACT [GOC:mah]
synonym: "stimulation of phospholipid biosynthetic process" NARROW [GOC:mah]
synonym: "up regulation of phospholipid biosynthetic process" EXACT [GOC:mah]
synonym: "up-regulation of phospholipid biosynthetic process" EXACT [GOC:mah]
synonym: "upregulation of phospholipid biosynthetic process" EXACT [GOC:mah]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0046889 ! positive regulation of lipid biosynthetic process
is_a: GO:0071071 ! regulation of phospholipid biosynthetic process
is_a: GO:1903727 ! positive regulation of phospholipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008654 ! phospholipid biosynthetic process
relationship: positively_regulates GO:0008654 ! phospholipid biosynthetic process
created_by: midori
creation_date: 2009-11-04T03:18:51Z

[Term]
id: GO:0071074
name: eukaryotic initiation factor eIF2 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]
is_a: GO:0031369 ! translation initiation factor binding
created_by: midori
creation_date: 2009-11-06T01:39:02Z

[Term]
id: GO:0071075
name: CUGBP1-eIF2 complex
namespace: cellular_component
def: "A protein complex that contains the eukaryotic translation initiation factor 2 complex (EIF2), CUG binding protein 1, and several endoplasmic reticulum proteins; the complex is involved in the regulation of translation." [PMID:16931514]
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part
created_by: midori
creation_date: 2009-11-06T01:43:30Z

[Term]
id: GO:0071076
name: RNA 3' uridylation
namespace: biological_process
def: "The enzymatic addition of a sequence of uridylyl residues at the 3' end of an RNA molecule." [GOC:vw, PMID:19430462]
is_a: GO:0031123 ! RNA 3'-end processing
created_by: midori
creation_date: 2009-11-06T02:41:23Z

[Term]
id: GO:0071077
name: adenosine 3',5'-bisphosphate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of adenosine 3',5'-bisphosphate from one side of a membrane to the other." [CHEBI:37240, GOC:mah, PubChem_Compound:159296]
synonym: "adenosine 3',5'-diphosphate transporter activity" EXACT [PubChem_Compound:159296]
synonym: "adenosine 3'-phosphate-5'-phosphate transmembrane transporter activity" EXACT [PubChem_Compound:159296]
is_a: GO:0000295 ! adenine nucleotide transmembrane transporter activity
is_a: GO:0005346 ! purine ribonucleotide transmembrane transporter activity
is_a: GO:0015211 ! purine nucleoside transmembrane transporter activity
relationship: part_of GO:0071106 ! adenosine 3',5'-bisphosphate transmembrane transport
created_by: midori
creation_date: 2009-11-06T03:44:14Z

[Term]
id: GO:0071078
name: fibronectin-tissue transglutaminase complex
namespace: cellular_component
def: "A protein complex that consists of fibronectin bound to tissue transglutaminase, and is involved in cell adhesion." [PMID:10684262]
synonym: "FN-TGM2 complex" NARROW [CORUM:2375]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-06T04:42:22Z

[Term]
id: GO:0071079
name: alpha2-beta1 integrin-chondroadherin complex
namespace: cellular_component
def: "A protein complex that consists of an alpha2-beta1 integrin complex bound to the cartilage matrix protein chondroadherin." [PMID:9281592]
synonym: "ITGA2-ITGB1-CHAD complex" NARROW [CORUM:2430]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-06T04:42:55Z

[Term]
id: GO:0071080
name: alpha3-beta1 integrin-basigin complex
namespace: cellular_component
def: "A protein complex that consists of an alpha3-beta1 integrin complex bound to the cell surface protein basigin." [PMID:9360995]
synonym: "ITGA3-ITGB1-BSG complex" NARROW [CORUM:2398]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-06T04:43:26Z

[Term]
id: GO:0071081
name: alpha3-beta1 integrin-CD63 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha3-beta1 integrin complex bound to the tetraspanin CD63." [PMID:7629079]
synonym: "ITGA3-ITGB1-CD63 complex" NARROW [CORUM:2399]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-06T04:43:43Z

[Term]
id: GO:0071082
name: alpha9-beta1 integrin-tenascin complex
namespace: cellular_component
def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to the extracellular matrix protein tenascin." [PMID:9565552]
synonym: "ITGA9-ITGB1-TNC complex" NARROW [CORUM:2443]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-06T04:43:58Z

[Term]
id: GO:0071083
name: alphaV-beta3 integrin-CD47-FCER2 complex
namespace: cellular_component
def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to the cell surface protein CD47 and the low-affinity immunoglobulin epsilon Fc receptor (FCER2)." [PMID:10037797]
synonym: "ITGAV-ITGB3-CD447-FCER2 complex" NARROW [CORUM:2355]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-06T04:44:20Z

[Term]
id: GO:0071084
name: alpha2-beta1 integrin-CD47 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha2-beta1 integrin complex bound to the cell surface protein CD47." [PMID:10397731]
synonym: "ITGA2-ITGB1-CD47 complex" NARROW [CORUM:2429]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-06T04:44:35Z

[Term]
id: GO:0071085
name: alphaIIb-beta3 integrin-CD9 complex
namespace: cellular_component
def: "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface protein CD9." [PMID:10429193]
synonym: "ITGA2b-ITGB3-CD9 complex" NARROW [CORUM:2370]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-06T04:44:52Z

[Term]
id: GO:0071086
name: alphaIIb-beta3 integrin-CD9-CD47-platelet glycoprotein Ib complex
namespace: cellular_component
def: "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface proteins CD9 and CD47, and the heterodimeric platelet glycoprotein Ib." [PMID:10429193]
synonym: "ITGA2b-ITGB3-CD9-GP1b-CD47 complex" NARROW [CORUM:2872]
is_a: GO:0090665 ! glycoprotein complex
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-06T04:45:08Z

[Term]
id: GO:0071087
name: alpha11-beta1 integrin-collagen type I complex
namespace: cellular_component
def: "A protein complex that consists of an alpha11-beta1 integrin complex bound to a type I collagen." [PMID:10464311]
synonym: "ITGA11-ITGB1-COL1A1 complex" NARROW [CORUM:3059]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-06T04:45:27Z

[Term]
id: GO:0071088
name: alpha5-beta1 integrin-tissue transglutaminase complex
namespace: cellular_component
def: "A protein complex that consists of an alpha5-beta1 integrin complex bound to tissue transglutaminase." [PMID:10684262]
synonym: "ITGA5-ITGB1-TGM2 complex" NARROW [CORUM:2433]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-06T04:45:47Z

[Term]
id: GO:0071089
name: alphaV-beta3 integrin-tissue transglutaminase complex
namespace: cellular_component
def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to tissue transglutaminase." [PMID:10684262]
synonym: "ITGAV-ITGB3-TGM2 complex" NARROW [CORUM:3095]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-06T04:46:02Z

[Term]
id: GO:0071090
name: alphaIIb-beta3 integrin-fibronectin-tissue transglutaminase complex
namespace: cellular_component
def: "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to fibronectin and tissue transglutaminase." [PMID:10684262]
synonym: "ITGA2b-ITGB3-FN1-TGM2 complex" NARROW [CORUM:2376]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-06T04:46:24Z

[Term]
id: GO:0071091
name: alpha1-beta1 integrin-tissue transglutaminase complex
namespace: cellular_component
def: "A protein complex that consists of an alpha1-beta1 integrin complex bound to tissue transglutaminase." [PMID:10684262]
synonym: "ITGA1-ITGB1-TGM2 complex" NARROW [CORUM:2894]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-06T04:46:44Z

[Term]
id: GO:0071092
name: alpha3-beta1 integrin-tissue transglutaminase complex
namespace: cellular_component
def: "A protein complex that consists of an alpha3-beta1 integrin complex bound to tissue transglutaminase." [PMID:10684262]
synonym: "ITGA3-ITGB1-TGM2 complex" NARROW [CORUM:2402]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-06T04:47:04Z

[Term]
id: GO:0071093
name: alpha5-beta1 integrin-fibronectin-tissue transglutaminase complex
namespace: cellular_component
def: "A protein complex that consists of an alpha5-beta1 integrin complex bound to fibronectin and tissue transglutaminase." [PMID:10684262]
synonym: "ITGA5-ITGB1-FN1-TGM2 complex" NARROW [CORUM:2383]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-06T04:47:22Z

[Term]
id: GO:0071094
name: alpha6-beta4 integrin-CD9 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha6-beta4 integrin complex bound to the cell surface protein CD9." [PMID:10711425]
synonym: "ITGA6-ITGB4-CD9 complex" NARROW [CORUM:2770]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-06T04:47:44Z

[Term]
id: GO:0071095
name: alpha3-beta1 integrin-thrombospondin complex
namespace: cellular_component
def: "A protein complex that consists of an alpha3-beta1 integrin complex bound to thrombospondin." [PMID:11358957]
synonym: "ITGA3-ITGB1-THBS1 complex" NARROW [CORUM:2401]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-06T04:48:03Z

[Term]
id: GO:0071096
name: alphaV-beta3 integrin-gelsolin complex
namespace: cellular_component
def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to gelsolin." [PMID:11577104]
synonym: "ITGAV-ITGB3-Gsn complex" NARROW [CORUM:2360]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-06T04:49:31Z

[Term]
id: GO:0071097
name: alphaV-beta3 integrin-paxillin-Pyk2 complex
namespace: cellular_component
def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to paxillin and the FAK-related kinase Pyk2." [PMID:11683411]
synonym: "ITGAV-ITGB3-PXN-PTK2b complex" NARROW [CORUM:2363]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-06T04:51:52Z

[Term]
id: GO:0071098
name: alpha6-beta4 integrin-Fyn complex
namespace: cellular_component
def: "A protein complex that consists of an alpha6-beta4 integrin complex bound to the Src family tyrosine kinase Fyn." [PMID:11684709]
synonym: "ITGA6-ITGB4-FYN complex" NARROW [CORUM:2321]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-06T04:52:10Z

[Term]
id: GO:0071099
name: alphaV-beta6 integrin-TGFbeta-3 complex
namespace: cellular_component
def: "A protein complex that consists of an alphaV-beta6 integrin complex bound to transforming growth factor beta-3 (TGFbeta-3)." [PMID:11821050]
synonym: "ITGAV-ITGB6-TFGB3 complex" NARROW [CORUM:2353]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-06T04:52:27Z

[Term]
id: GO:0071100
name: alphaV-beta8 integrin-MMP14-TGFbeta-1 complex
namespace: cellular_component
def: "A protein complex that consists of an alphaV-beta8 integrin complex bound to matrix metalloproteinase 14 and transforming growth factor beta-1 (TGFbeta-1)." [PMID:11970960]
synonym: "ITGAV-ITGB8-MMP14-TGFB1 complex" NARROW [CORUM:2342]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-06T04:52:43Z

[Term]
id: GO:0071101
name: alpha4-beta1 integrin-JAM2 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to the cell adhesion molecule JAM2." [PMID:12070135]
synonym: "ITGA4-ITGB1-JAM2 complex" NARROW [CORUM:2422]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-06T04:52:59Z

[Term]
id: GO:0071102
name: alpha4-beta1 integrin-paxillin complex
namespace: cellular_component
def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to paxillin." [PMID:12221126]
synonym: "ITGA4-ITGB1-PXN complex" NARROW [CORUM:2425]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-06T04:53:22Z

[Term]
id: GO:0071103
name: DNA conformation change
namespace: biological_process
def: "A cellular process that results in a change in the spatial configuration of a DNA molecule. A conformation change can bend DNA, or alter the, twist, writhe, or linking number of a DNA molecule." [GOC:mah]
subset: gosubset_prok
synonym: "DNA conformation modification" EXACT [GOC:mah]
is_a: GO:0051276 ! chromosome organization
created_by: midori
creation_date: 2009-11-09T11:36:34Z

[Term]
id: GO:0071104
name: response to interleukin-9
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-9 stimulus." [GOC:mah, GOC:yaf]
synonym: "response to IL-9" EXACT [GOC:mah]
is_a: GO:0034097 ! response to cytokine
created_by: midori
creation_date: 2009-11-09T12:50:25Z

[Term]
id: GO:0071105
name: response to interleukin-11
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-11 stimulus." [GOC:mah, GOC:yaf]
synonym: "response to IL-11" EXACT [GOC:mah]
is_a: GO:0034097 ! response to cytokine
created_by: midori
creation_date: 2009-11-09T12:52:51Z

[Term]
id: GO:0071106
name: adenosine 3',5'-bisphosphate transmembrane transport
namespace: biological_process
def: "The directed movement of adenosine 3',5'-bisphosphate across a membrane into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:37240, GOC:mah, PubChem_Compound:159296]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "adenosine 3',5'-bisphosphate membrane transport" EXACT []
synonym: "adenosine 3',5'-diphosphate transport" EXACT [PubChem_Compound:159296]
synonym: "adenosine 3'-phosphate-5'-phosphate transmembrane transport" EXACT [PubChem_Compound:159296]
is_a: GO:0015860 ! purine nucleoside transmembrane transport
is_a: GO:0015868 ! purine ribonucleotide transport
is_a: GO:0051503 ! adenine nucleotide transport
is_a: GO:1901679 ! nucleotide transmembrane transport
created_by: midori
creation_date: 2009-11-12T10:40:49Z

[Term]
id: GO:0071107
name: response to parathyroid hormone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a parathyroid hormone stimulus." [GOC:mah, GOC:yaf]
synonym: "response to parathyroid hormone stimulus" EXACT [GOC:dos]
is_a: GO:0009725 ! response to hormone
created_by: midori
creation_date: 2009-11-12T10:58:45Z

[Term]
id: GO:0071108
name: protein K48-linked deubiquitination
namespace: biological_process
def: "A protein deubiquitination process in which a K48-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is removed from a protein." [GOC:mah]
is_a: GO:0016579 ! protein deubiquitination
created_by: midori
creation_date: 2009-11-12T01:34:01Z

[Term]
id: GO:0071109
name: superior temporal gyrus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the superior temporal gyrus over time, from its formation to the mature structure. The superior temporal gyrus is a portion of the cerebral cortex that extends from the lateral sulcus to the superior temporal sulcus." [FMA:61905, GOC:BHF, GOC:mah, PMID:11484000]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021987 ! cerebral cortex development
created_by: midori
creation_date: 2009-11-12T02:19:23Z

[Term]
id: GO:0071110
name: histone biotinylation
namespace: biological_process
def: "The modification of a histone by the addition of a biotinyl group." [GOC:rph, PMID:14613969, PMID:19019041]
is_a: GO:0009305 ! protein biotinylation
is_a: GO:0016570 ! histone modification
created_by: midori
creation_date: 2009-11-13T01:22:59Z

[Term]
id: GO:0071111
name: cyclic-guanylate-specific phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyclic di-3',5'-guanylate + H(2)O = 5'-phosphoguanylyl(3'->5')guanosine + H(+)." [EC:3.1.4.52, RHEA:24905]
subset: gosubset_prok
synonym: "c-di-GMP phosphodiesterase activity" EXACT [EC:3.1.4.52]
synonym: "c-di-GMP-specific phosphodiesterase activity" EXACT [EC:3.1.4.52]
synonym: "cyclic bis(3->5')diguanylate phosphodiesterase activity" EXACT [EC:3.1.4.52]
synonym: "PDEA1" RELATED [EC:3.1.4.52]
synonym: "phosphodiesterase A1 activity" RELATED [EC:3.1.4.52]
synonym: "VieA" RELATED [EC:3.1.4.52]
xref: EC:3.1.4.52
xref: KEGG:R08991
xref: MetaCyc:RXN0-4181
xref: RHEA:24905
is_a: GO:0008081 ! phosphoric diester hydrolase activity
created_by: midori
creation_date: 2009-11-13T02:10:39Z

[Term]
id: GO:0071112
name: alpha4-beta4 integrin-EMILIN-1 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha4-beta4 integrin complex bound to EMILIN-1 (ElastinMicrofibril Interface Located ProteIN)." [PMID:12456677]
synonym: "ITGA4-ITGB4-EMILIN1 complex" NARROW [CORUM:2417]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-13T02:17:11Z

[Term]
id: GO:0071113
name: alphaIIb-beta3 integrin-ICAM-4 complex
namespace: cellular_component
def: "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell adhesion molecule ICAM-4." [PMID:12477717]
synonym: "ITGAIIb-ITGB3-ICAM4 complex" NARROW [CORUM:3115]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-13T02:17:59Z

[Term]
id: GO:0071114
name: alphaV-beta3 integrin-tumstatin complex
namespace: cellular_component
def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to tumstatin, the NC1 domain of the alpha3 chain of type IV collagen." [PMID:12682293]
synonym: "ITGAV-ITGB3-COL4A3 complex" NARROW [CORUM:2365]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-13T02:18:29Z

[Term]
id: GO:0071115
name: alpha5-beta1 integrin-endostatin complex
namespace: cellular_component
def: "A protein complex that consists of an alpha5-beta1 integrin complex bound to endostatin, the NC1 domain of the alpha1 chain of type XVIII collagen." [PMID:12682293]
synonym: "ITGA5-ITGB1-CAL4A3 complex" NARROW [CORUM:2853]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-13T02:18:57Z

[Term]
id: GO:0071116
name: alpha6-beta1 integrin-CYR61 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha6-beta1 integrin complex bound to CYR61, a cysteine-rich protein involved in angiogenesis." [PMID:12826661]
synonym: "ITGA6-ITGB1-CYR61 complex" NARROW [CORUM:2437]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-13T02:19:23Z

[Term]
id: GO:0071117
name: alpha5-beta1 integrin-fibronectin-NOV complex
namespace: cellular_component
def: "A protein complex that consists of an alpha5-beta1 integrin complex bound to fibronectin and the extracellular matrix protein NOV." [PMID:12902636]
synonym: "ITGA5-ITGB1-FN-1-NOV complex" NARROW [CORUM:2850]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-13T02:19:52Z

[Term]
id: GO:0071118
name: alphaV-beta3 integrin-NOV complex
namespace: cellular_component
def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to the extracellular matrix protein NOV." [PMID:12902636]
synonym: "ITGAV-ITGB3-FN-1-NOV complex" NARROW [CORUM:2849]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-13T02:20:20Z

[Term]
id: GO:0071119
name: alpha7-beta1 integrin-nicotinamide riboside kinase complex
namespace: cellular_component
def: "A protein complex that consists of an alpha7-beta1 integrin complex bound to nicotinamide riboside kinase 2 (also known as muscle integrin binding protein, MIBP)." [PMID:12941630]
synonym: "ITGA7-ITGB1-ITGB1BP3 complex" NARROW [CORUM:2397]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-13T02:20:44Z

[Term]
id: GO:0071120
name: alpha4-beta1 integrin-CD47 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to the cell surface antigen CD47." [PMID:15292185]
synonym: "ITGA4-ITGB1-CB47 complex" NARROW [CORUM:2423]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-13T02:21:10Z

[Term]
id: GO:0071121
name: alpha9-beta1 integrin-VEGF-D complex
namespace: cellular_component
def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular endothelial growth factor D." [PMID:15590642]
synonym: "ITGA9-ITGB1-FIGF complex" NARROW [CORUM:2446]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-13T02:21:37Z

[Term]
id: GO:0071122
name: alpha9-beta1 integrin-VEGF-A complex
namespace: cellular_component
def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular endothelial growth factor A." [PMID:17363377]
synonym: "ITGA9-ITGB1-VEGFA complex" NARROW [CORUM:2972]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-13T02:22:01Z

[Term]
id: GO:0071123
name: alpha9-beta1 integrin-VEGF-C complex
namespace: cellular_component
def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular endothelial growth factor C." [PMID:15590642]
synonym: "ITGA9-ITGB1-VEGFC complex" NARROW [CORUM:2971]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-13T02:22:27Z

[Term]
id: GO:0071124
name: alpha1-beta1 integrin-tyrosine-protein phosphatase non-receptor type 2 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha1-beta1 integrin complex bound to tyrosine-protein phosphatase non-receptor type 2." [PMID:15592458]
synonym: "ITGA1-ITGB1-PTPN2 complex" NARROW [CORUM:2435]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-13T02:22:51Z

[Term]
id: GO:0071125
name: alphaV-beta3 integrin-EGFR complex
namespace: cellular_component
def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to epidermal growth factor receptor." [PMID:15834425]
synonym: "ITGAV-ITGB3-EGFR complex" NARROW [CORUM:2369]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-13T02:23:18Z

[Term]
id: GO:0071126
name: alphaV-beta6 integrin-osteopontin complex
namespace: cellular_component
def: "A protein complex that consists of an alphaV-beta6 integrin complex bound to osteopontin." [PMID:16005200]
synonym: "ITGAV-ITGB6-SPP1 complex" NARROW [CORUM:2352]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-13T02:23:43Z

[Term]
id: GO:0071127
name: alpha9-beta1 integrin-osteopontin complex
namespace: cellular_component
def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to osteopontin." [PMID:16005200]
synonym: "ITGA9-ITGB1-SPP1 complex" NARROW [CORUM:3111]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-13T02:24:09Z

[Term]
id: GO:0071128
name: alpha5-beta1 integrin-osteopontin complex
namespace: cellular_component
def: "A protein complex that consists of an alpha5-beta1 integrin complex bound to osteopontin." [PMID:16005200]
synonym: "ITGA5-ITGB1-SPP1 complex" NARROW [CORUM:3112]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-13T02:24:43Z

[Term]
id: GO:0071129
name: alphaV-beta3 integrin-LPP3 complex
namespace: cellular_component
def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to lipid phosphate phosphohydrolase-3." [PMID:16099422]
synonym: "ITGAV-ITGB3-PPAP2B complex" NARROW [CORUM:2366]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-13T02:25:17Z

[Term]
id: GO:0071130
name: alpha5-beta1 integrin-LPP3 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha5-beta1 integrin complex bound to lipid phosphate phosphohydrolase-3." [PMID:16099422]
synonym: "ITGA5-ITGB1-PPAP2B complex" NARROW [CORUM:2386]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-13T02:25:47Z

[Term]
id: GO:0071131
name: alphaV-beta3 integrin-laminin alpha-4 complex
namespace: cellular_component
def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to laminin alpha-4." [PMID:16824487]
synonym: "ITGAV-ITGB3-LAMA4 complex" NARROW [CORUM:2374]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-13T02:26:11Z

[Term]
id: GO:0071132
name: alphaX-beta2 integrin-ICAM-4 complex
namespace: cellular_component
def: "A protein complex that consists of an alphaX-beta2 integrin complex bound to intercellular adhesion molecule 4." [PMID:16985175]
synonym: "ITGAX-ITGB2-ICAM4 complex" NARROW [CORUM:3114]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-13T02:28:30Z

[Term]
id: GO:0071133
name: alpha9-beta1 integrin-ADAM8 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM8." [PMID:16995821]
synonym: "ITGA9-ITGB1-ADAM8 complex" NARROW [CORUM:2989]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-13T02:28:49Z

[Term]
id: GO:0071134
name: alpha9-beta1 integrin-thrombospondin-1 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to thrombospondin-1." [PMID:17413041]
synonym: "ITGA9-ITGB1-THBS1 complex" NARROW [CORUM:2967]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-13T02:29:07Z

[Term]
id: GO:0071135
name: alpha7-beta1 integrin-focal adhesion kinase complex
namespace: cellular_component
def: "A protein complex that consists of an alpha7-beta1 integrin complex bound to focal adhesion kinase." [PMID:17598176]
synonym: "ITGA7-ITGB1-PTK2 complex" NARROW [CORUM:3106]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-13T02:29:24Z

[Term]
id: GO:0071136
name: alpha7-beta1 integrin-laminin alpha-2 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha7-beta1 integrin complex bound to laminin alpha-2." [PMID:17598176]
synonym: "ITGA7-ITGB1-LAMA2 complex" NARROW [CORUM:3105]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-13T02:29:42Z

[Term]
id: GO:0071137
name: alphaV-beta3 integrin-CD98 complex
namespace: cellular_component
def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to the cell surface antigen CD98." [PMID:18032696]
synonym: "ITGAV-ITGB3-SLC3A2 complex" NARROW [CORUM:3103]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-13T02:29:59Z

[Term]
id: GO:0071138
name: alpha5-beta5-fibronectin-SFRP2 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha5-beta5 integrin complex bound to fibronectin and secreted frizzled-related protein 2." [PMID:14709558]
synonym: "ITGA5-ITGB5-FN-1-SFRP2 complex" NARROW [CORUM:2388]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-13T02:30:31Z

[Term]
id: GO:0071139
name: resolution of recombination intermediates
namespace: biological_process
def: "The cleavage and rejoining of intermediates, such as Holliday junctions, formed during DNA recombination to produce two intact molecules in which genetic material has been exchanged." [GOC:elh, GOC:mah, GOC:vw]
is_a: GO:0006259 ! DNA metabolic process
relationship: part_of GO:0006310 ! DNA recombination
created_by: midori
creation_date: 2009-11-16T12:02:21Z

[Term]
id: GO:0071140
name: resolution of mitotic recombination intermediates
namespace: biological_process
def: "The cleavage and rejoining of intermediates, mitotic recombination to produce two intact molecules in which genetic material has been exchanged." [GOC:elh, GOC:mah, GOC:vw]
is_a: GO:0071139 ! resolution of recombination intermediates
relationship: part_of GO:0006312 ! mitotic recombination
created_by: midori
creation_date: 2009-11-16T12:06:05Z

[Term]
id: GO:0071141
name: SMAD protein complex
namespace: cellular_component
def: "A protein complex that consists of SMAD proteins; may be homomeric or heteromeric." [GOC:mah, PMID:9670020]
synonym: "SMAD complex" EXACT [GOC:mah]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
created_by: midori
creation_date: 2009-11-16T02:28:59Z

[Term]
id: GO:0071142
name: SMAD2 protein complex
namespace: cellular_component
def: "A protein complex that consists of a SMAD2 homotrimer." [GOC:mah, PMID:9670020]
synonym: "SMAD2 homotrimer complex" EXACT [CORUM:2999]
is_a: GO:0071141 ! SMAD protein complex
created_by: midori
creation_date: 2009-11-16T02:39:33Z

[Term]
id: GO:0071143
name: SMAD3 protein complex
namespace: cellular_component
def: "A protein complex that consists of a SMAD3 homotrimer." [GOC:mah, PMID:9670020]
synonym: "SMAD3 homotrimer complex" EXACT [CORUM:3003]
is_a: GO:0071141 ! SMAD protein complex
created_by: midori
creation_date: 2009-11-16T02:41:19Z

[Term]
id: GO:0071144
name: SMAD2-SMAD3 protein complex
namespace: cellular_component
def: "A heteromeric SMAD protein complex that contains SMAD2 and SMAD3." [GOC:mah, PMID:9670020]
synonym: "SMAD2-SMAD3 complex" EXACT [CORUM:3000]
is_a: GO:0005667 ! transcription factor complex
is_a: GO:0071141 ! SMAD protein complex
created_by: midori
creation_date: 2009-11-16T02:44:37Z

[Term]
id: GO:0071145
name: SMAD2-SMAD4 protein complex
namespace: cellular_component
def: "A heteromeric SMAD protein complex that contains SMAD2 and SMAD4." [GOC:mah, PMID:9670020]
synonym: "SMAD2-SMAD4 heteromer complex" EXACT [CORUM:3001]
is_a: GO:0005667 ! transcription factor complex
is_a: GO:0071141 ! SMAD protein complex
created_by: midori
creation_date: 2009-11-16T02:47:15Z

[Term]
id: GO:0071146
name: SMAD3-SMAD4 protein complex
namespace: cellular_component
def: "A heteromeric SMAD protein complex that contains SMAD3 and SMAD4." [GOC:mah, PMID:9670020]
synonym: "SMAD3-SMAD4 complex" EXACT [CORUM:3002]
is_a: GO:0005667 ! transcription factor complex
is_a: GO:0071141 ! SMAD protein complex
created_by: midori
creation_date: 2009-11-16T02:50:36Z

[Term]
id: GO:0071147
name: TEAD-2 multiprotein complex
namespace: cellular_component
def: "A protein complex that consists of the DNA binding protein TEAD-2 bound to 12 other polypeptides including the transcriptional coactivator YAP, the multi-PDZ domain protein MPDZ (also called MUPP1), a 14-3-3 domain protein, and others." [CORUM:2870, GOC:mah, PMID:11358867]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
created_by: midori
creation_date: 2009-11-16T03:31:35Z

[Term]
id: GO:0071148
name: TEAD-1-YAP complex
namespace: cellular_component
def: "A transcription factor complex that is composed of the DNA binding protein TEAD-1 and the transcriptional coactivator YAP." [GOC:mah, PMID:11358867]
is_a: GO:0090575 ! RNA polymerase II transcription factor complex
created_by: midori
creation_date: 2009-11-16T03:38:43Z

[Term]
id: GO:0071149
name: TEAD-2-YAP complex
namespace: cellular_component
def: "A transcription factor complex that is composed of the DNA binding protein TEAD-2 and the transcriptional coactivator YAP." [GOC:mah, PMID:11358867]
is_a: GO:0090575 ! RNA polymerase II transcription factor complex
created_by: midori
creation_date: 2009-11-16T03:58:10Z

[Term]
id: GO:0071150
name: TEAD-3-YAP complex
namespace: cellular_component
def: "A transcription factor complex that is composed of the DNA binding protein TEAD-3 and the transcriptional coactivator YAP." [GOC:mah, PMID:11358867]
is_a: GO:0090575 ! RNA polymerase II transcription factor complex
created_by: midori
creation_date: 2009-11-16T03:58:31Z

[Term]
id: GO:0071151
name: TEAD-4-YAP complex
namespace: cellular_component
def: "A transcription factor complex that is composed of the DNA binding protein TEAD-4 and the transcriptional coactivator YAP." [GOC:mah, PMID:11358867]
is_a: GO:0090575 ! RNA polymerase II transcription factor complex
created_by: midori
creation_date: 2009-11-16T03:58:48Z

[Term]
id: GO:0071152
name: G-protein alpha(q)-synembrin complex
namespace: cellular_component
def: "A protein complex formed by the association of the guanine nucleotide exchange factor synembrin with the alpha(q) subunit of a heterotrimeric G protein." [GOC:mah, PMID:12509430]
synonym: "Ric-8A G(q) alpha subunit complex" NARROW [CORUM:175]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
created_by: midori
creation_date: 2009-11-16T04:48:05Z

[Term]
id: GO:0071153
name: G-protein alpha(o)-synembrin complex
namespace: cellular_component
def: "A protein complex formed by the association of the guanine nucleotide exchange factor synembrin with the alpha(o) subunit of a heterotrimeric G protein." [GOC:mah, PMID:12509430]
synonym: "Ric-8A G(o) alpha-1 subunit complex" NARROW [CORUM:172]
synonym: "Ric-8A G(o) alpha-2 subunit complex" NARROW [CORUM:174]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
created_by: midori
creation_date: 2009-11-16T04:55:00Z

[Term]
id: GO:0071154
name: G-protein alpha(i)1-synembrin complex
namespace: cellular_component
def: "A protein complex formed by the association of the guanine nucleotide exchange factor synembrin with the alpha(i)1 subunit of a heterotrimeric G protein." [GOC:mah, PMID:12509430]
synonym: "Ric-8A G(i) alpha-1 subunit complex" NARROW [CORUM:170]
synonym: "Ric-8A G(i) alpha-2 subunit complex" RELATED [CORUM:171]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
created_by: midori
creation_date: 2009-11-16T04:57:46Z

[Term]
id: GO:0071155
name: G-protein alpha(13)-synembrin complex
namespace: cellular_component
def: "A protein complex formed by the association of the guanine nucleotide exchange factor synembrin with the alpha(13) subunit of a heterotrimeric G protein." [GOC:mah, PMID:12509430]
synonym: "Ric-8A G alpha 13 subunit complex" NARROW [CORUM:176]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
created_by: midori
creation_date: 2009-11-16T05:01:55Z

[Term]
id: GO:0071156
name: regulation of cell cycle arrest
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of cell cycle arrest, the process in which the cell cycle is halted during one of the normal phases." [GOC:mah]
is_a: GO:0010564 ! regulation of cell cycle process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007050 ! cell cycle arrest
relationship: regulates GO:0007050 ! cell cycle arrest
created_by: midori
creation_date: 2009-11-17T01:38:39Z

[Term]
id: GO:0071157
name: negative regulation of cell cycle arrest
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of cell cycle arrest, the process in which the cell cycle is halted during one of the normal phases." [GOC:mah]
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0045787 ! positive regulation of cell cycle
is_a: GO:0071156 ! regulation of cell cycle arrest
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007050 ! cell cycle arrest
relationship: negatively_regulates GO:0007050 ! cell cycle arrest
created_by: midori
creation_date: 2009-11-17T01:42:57Z

[Term]
id: GO:0071158
name: positive regulation of cell cycle arrest
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of cell cycle arrest, the process in which the cell cycle is halted during one of the normal phases." [GOC:mah]
is_a: GO:0071156 ! regulation of cell cycle arrest
is_a: GO:0090068 ! positive regulation of cell cycle process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007050 ! cell cycle arrest
relationship: positively_regulates GO:0007050 ! cell cycle arrest
created_by: midori
creation_date: 2009-11-17T01:43:47Z

[Term]
id: GO:0071159
name: NF-kappaB complex
namespace: cellular_component
def: "A protein complex that consists of a homo- or heterodimer of members of a family of structurally related proteins that contain a conserved N-terminal region called the Rel homology domain (RHD). In the nucleus, NF-kappaB complexes act as transcription factors. In unstimulated cells, NF-kappaB dimers are sequestered in the cytoplasm by IkappaB monomers; signals that induce NF-kappaB activity cause degradation of IkappaB, allowing NF-kappaB dimers to translocate to the nucleus and induce gene expression." [ISBN:0849327946]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
created_by: midori
creation_date: 2009-11-17T02:03:34Z

[Term]
id: GO:0071160
name: cyanophycin synthetase activity (L-aspartate-adding)
namespace: molecular_function
def: "Catalysis of the reaction: ATP + [L-Asp(4-L-Arg)]n + L-Asp = ADP + phosphate + [L-Asp(4-L-Arg)]n-L-Asp." [EC:6.3.2.29]
subset: gosubset_prok
xref: EC:6.3.2.29
is_a: GO:0043860 ! cyanophycin synthetase activity
created_by: midori
creation_date: 2009-11-17T05:18:17Z

[Term]
id: GO:0071161
name: cyanophycin synthetase activity (L-arginine-adding)
namespace: molecular_function
def: "Catalysis of the reaction: ATP + [L-Asp(4-L-Arg)]n-L-Asp + L-arginine = ADP + phosphate + [L-Asp(4-L-Arg)]n+1." [EC:6.3.2.30]
subset: gosubset_prok
xref: EC:6.3.2.30
is_a: GO:0043860 ! cyanophycin synthetase activity
created_by: midori
creation_date: 2009-11-17T05:19:54Z

[Term]
id: GO:0071162
name: CMG complex
namespace: cellular_component
def: "A protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication." [GOC:rb, PMID:19228417]
synonym: "unwindosome" EXACT [PMID:19228417]
is_a: GO:0031261 ! DNA replication preinitiation complex
is_a: GO:0044454 ! nuclear chromosome part
relationship: has_part GO:0000811 ! GINS complex
relationship: has_part GO:0042555 ! MCM complex
created_by: midori
creation_date: 2009-11-19T11:04:13Z

[Term]
id: GO:0071163
name: DNA replication preinitiation complex assembly
namespace: biological_process
alt_id: GO:1902293
alt_id: GO:1902316
def: "The aggregation, arrangement and bonding together of a set of components to form the DNA replication preinitiation complex, a protein-DNA complex that is assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication, by the assembly of additional proteins onto an existing prereplicative complex." [GOC:mah]
synonym: "DNA replication preinitiation complex formation" EXACT [GOC:mah]
synonym: "pre-IC complex assembly" EXACT []
is_a: GO:0022402 ! cell cycle process
is_a: GO:0065004 ! protein-DNA complex assembly
relationship: part_of GO:0033260 ! nuclear DNA replication
created_by: midori
creation_date: 2009-11-19T11:13:41Z

[Term]
id: GO:0071164
name: RNA trimethylguanosine synthase activity
namespace: molecular_function
def: "Catalysis of two successive methyl transfer reactions from AdoMet to the N-2 atom of guanosine, thereby converting 7-methylguanosine in an RNA cap to 2,2,7 trimethylguanosine." [GOC:BHF, PMID:11983179, PMID:18775984]
synonym: "cap hypermethylase activity" EXACT [PMID:11983179]
synonym: "small nuclear RNA methyltransferase activity" RELATED [GOC:rl]
synonym: "snRNA methyltransferase activity" RELATED [GOC:rl]
is_a: GO:0008173 ! RNA methyltransferase activity
relationship: part_of GO:0036261 ! 7-methylguanosine cap hypermethylation
created_by: midori
creation_date: 2009-11-19T03:23:20Z

[Term]
id: GO:0071165
name: GINS complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a GINS complex, a heterotetrameric protein complex that associates with DNA replication origins and replication forks." [GOC:mah, PMID:16990792]
is_a: GO:0043623 ! cellular protein complex assembly
is_a: GO:0071163 ! DNA replication preinitiation complex assembly
created_by: midori
creation_date: 2009-11-19T03:37:20Z

[Term]
id: GO:0071166
name: ribonucleoprotein complex localization
namespace: biological_process
def: "Any process in which a ribonucleoprotein complex is transported to, or maintained in, a specific location within a cell." [GOC:mah]
synonym: "cellular ribonucleoprotein complex localization" EXACT [GOC:mah]
synonym: "establishment and maintenance of ribonucleoprotein complex localization" EXACT [GOC:mah]
synonym: "ribonucleoprotein complex localisation" EXACT [GOC:mah]
synonym: "RNP localization" EXACT [GOC:mah]
is_a: GO:0051641 ! cellular localization
created_by: midori
creation_date: 2009-11-19T04:46:05Z

[Term]
id: GO:0071167
name: ribonucleoprotein complex import into nucleus
namespace: biological_process
def: "The directed movement of a ribonucleoprotein complex from the cytoplasm to the nucleus." [GOC:BHF, GOC:mah]
synonym: "ribonucleoprotein complex import into cell nucleus" EXACT [GOC:mah]
synonym: "ribonucleoprotein complex nucleus import" EXACT [GOC:mah]
synonym: "ribonucleoprotein complex targeting to nucleus" EXACT [GOC:mah]
synonym: "ribonucleoprotein complex transport from cytoplasm to nucleus" EXACT [GOC:mah]
synonym: "ribonucleoprotein import into nucleus" EXACT [GOC:rl]
synonym: "RNP import into nucleus" EXACT [GOC:mah]
is_a: GO:0051170 ! nuclear import
relationship: part_of GO:0071166 ! ribonucleoprotein complex localization
created_by: midori
creation_date: 2009-11-19T04:48:42Z

[Term]
id: GO:0071168
name: protein localization to chromatin
namespace: biological_process
def: "Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin." [GOC:mah]
synonym: "protein localisation to chromatin" EXACT [GOC:mah]
is_a: GO:0034502 ! protein localization to chromosome
created_by: midori
creation_date: 2009-11-20T11:51:20Z

[Term]
id: GO:0071169
name: establishment of protein localization to chromatin
namespace: biological_process
def: "The directed movement of a protein to a part of a chromosome that is organized into chromatin." [GOC:mah]
synonym: "establishment of protein localisation to chromatin" EXACT [GOC:mah]
is_a: GO:0070199 ! establishment of protein localization to chromosome
relationship: part_of GO:0071168 ! protein localization to chromatin
created_by: midori
creation_date: 2009-11-20T11:52:43Z

[Term]
id: GO:0071170
name: site-specific DNA replication termination
namespace: biological_process
def: "A DNA replication termination process that takes place at a specific termination site." [GOC:mah, PMID:12009298, PMID:18723894]
comment: See also the biological process term 'replication fork arrest ; GO:0043111' and its children.
is_a: GO:0006274 ! DNA replication termination
created_by: midori
creation_date: 2009-11-20T01:07:30Z

[Term]
id: GO:0071171
name: site-specific DNA replication termination at RTS1 barrier
namespace: biological_process
def: "A DNA replication termination process that takes place at the RTS1 termination site in the mating type locus, in a specific direction required for subsequent imprinting and mating-type switching." [GOC:vw, PMID:12009298, PMID:18723894]
is_a: GO:0071170 ! site-specific DNA replication termination
relationship: part_of GO:0071516 ! establishment of imprinting at mating-type locus
created_by: midori
creation_date: 2009-11-20T01:24:41Z

[Term]
id: GO:0071172
name: dihydromonapterin reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7,8-dihydromonapterin + NADPH = tetrahydromonapterin + NADP+." [GOC:imk, PMID:19897652]
subset: gosubset_prok
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
created_by: midori
creation_date: 2009-11-23T11:10:17Z

[Term]
id: GO:0071173
name: spindle assembly checkpoint
namespace: biological_process
def: "A cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and chromosomes are attached to the spindle." [GOC:mah]
comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of spindle assembly checkpoint (mitotic or meiotic).
subset: gocheck_do_not_manually_annotate
synonym: "SAC" BROAD [GOC:mah]
is_a: GO:0031577 ! spindle checkpoint
created_by: midori
creation_date: 2009-11-23T12:36:57Z

[Term]
id: GO:0071174
name: mitotic spindle checkpoint
namespace: biological_process
def: "A mitotic cell cycle checkpoint that originates from the spindle and delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and oriented, the completion of anaphase until chromosomes are attached to the spindle, or mitotic exit and cytokinesis when the spindle does not form." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of spindle checkpoint (assembly, orientation or Dma1-dependent).
subset: gocheck_do_not_manually_annotate
synonym: "mitotic cell cycle spindle checkpoint" EXACT []
is_a: GO:0007093 ! mitotic cell cycle checkpoint
is_a: GO:0031577 ! spindle checkpoint
is_a: GO:0045841 ! negative regulation of mitotic metaphase/anaphase transition
intersection_of: GO:0031577 ! spindle checkpoint
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: negatively_regulates GO:0007091 ! metaphase/anaphase transition of mitotic cell cycle
relationship: part_of GO:0000278 ! mitotic cell cycle
created_by: midori
creation_date: 2009-11-23T12:41:36Z

[Term]
id: GO:0071175
name: MAML2-RBP-Jkappa-ICN1 complex
namespace: cellular_component
def: "A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-2 (MAML2); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [PMID:12370315]
synonym: "MAML2-RBP-Jkappa-Notch1 complex" EXACT [CORUM:1949]
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part
created_by: midori
creation_date: 2009-11-23T02:36:28Z

[Term]
id: GO:0071176
name: MAML2-RBP-Jkappa-ICN2 complex
namespace: cellular_component
def: "A protein complex that consists of the intracellular domain of Notch2 (ICN2), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-2 (MAML2); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [PMID:12370315]
synonym: "MAML2-RBP-Jkappa-Notch2 complex" EXACT [CORUM:3217]
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part
created_by: midori
creation_date: 2009-11-23T02:42:24Z

[Term]
id: GO:0071177
name: MAML2-RBP-Jkappa-ICN3 complex
namespace: cellular_component
def: "A protein complex that consists of the intracellular domain of Notch3 (ICN3), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-2 (MAML2); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [PMID:12370315]
synonym: "MAML2-RBP-Jkappa-Notch3 complex" EXACT [CORUM:3218]
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part
created_by: midori
creation_date: 2009-11-23T02:48:56Z

[Term]
id: GO:0071178
name: MAML2-RBP-Jkappa-ICN4 complex
namespace: cellular_component
def: "A protein complex that consists of the intracellular domain of Notch4 (ICN4), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-2 (MAML2); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [PMID:12370315]
synonym: "MAML2-RBP-Jkappa-Notch4 complex" EXACT [CORUM:3219]
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part
created_by: midori
creation_date: 2009-11-23T02:49:21Z

[Term]
id: GO:0071179
name: MAML3-RBP-Jkappa-ICN1 complex
namespace: cellular_component
def: "A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-3 (MAML3); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [PMID:12370315]
synonym: "MAML3-RBP-Jkappa-Notch1 complex" EXACT [CORUM:3220]
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part
created_by: midori
creation_date: 2009-11-23T02:50:39Z

[Term]
id: GO:0071180
name: MAML3-RBP-Jkappa-ICN2 complex
namespace: cellular_component
def: "A protein complex that consists of the intracellular domain of Notch2 (ICN2), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-3 (MAML3); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [PMID:12370315]
synonym: "MAML3-RBP-Jkappa-Notch2 complex" EXACT [CORUM:3221]
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part
created_by: midori
creation_date: 2009-11-23T02:51:29Z

[Term]
id: GO:0071181
name: MAML3-RBP-Jkappa-ICN3 complex
namespace: cellular_component
def: "A protein complex that consists of the intracellular domain of Notch3 (ICN3), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-3 (MAML3); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [PMID:12370315]
synonym: "MAML3-RBP-Jkappa-Notch3 complex" EXACT [CORUM:3222]
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part
created_by: midori
creation_date: 2009-11-23T02:52:05Z

[Term]
id: GO:0071182
name: MAML3-RBP-Jkappa-ICN4 complex
namespace: cellular_component
def: "A protein complex that consists of the intracellular domain of Notch4 (ICN4), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-3 (MAML3); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [PMID:12370315]
synonym: "MAML3-RBP-Jkappa-Notch4 complex" EXACT [CORUM:3223]
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part
created_by: midori
creation_date: 2009-11-23T02:52:35Z

[Term]
id: GO:0071183
name: protocadherin-alpha-protocadherin-gamma complex
namespace: cellular_component
def: "A protein complex that contains two cell adhesion molecules, a protocadherin-alpha and a protocadherin-gamma, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: midori
creation_date: 2009-11-23T04:10:30Z

[Term]
id: GO:0071184
name: protocadherin-alpha-v4-protocadherin-gamma-a1 complex
namespace: cellular_component
def: "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-a1, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688]
synonym: "Pcdhga1-Pcdha4 complex" NARROW [CORUM:1014]
is_a: GO:0071183 ! protocadherin-alpha-protocadherin-gamma complex
created_by: midori
creation_date: 2009-11-23T04:11:47Z

[Term]
id: GO:0071185
name: protocadherin-alpha-v4-protocadherin-gamma-a3 complex
namespace: cellular_component
def: "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-a3, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688]
synonym: "Pcdhga1-Pcdhga3 complex" NARROW [CORUM:1016]
is_a: GO:0071183 ! protocadherin-alpha-protocadherin-gamma complex
created_by: midori
creation_date: 2009-11-23T04:16:47Z

[Term]
id: GO:0071186
name: protocadherin-alpha-v4-protocadherin-gamma-b2 complex
namespace: cellular_component
def: "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-b2, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688]
synonym: "Pcdhga1-Pcdhgb2 complex" NARROW [CORUM:1015]
is_a: GO:0071183 ! protocadherin-alpha-protocadherin-gamma complex
created_by: midori
creation_date: 2009-11-23T04:21:33Z

[Term]
id: GO:0071187
name: protocadherin-alpha-v4-protocadherin-gamma-b4 complex
namespace: cellular_component
def: "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-b4, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688]
synonym: "Pcdhga1-Pcdhgb4 complex" NARROW [CORUM:1017]
is_a: GO:0071183 ! protocadherin-alpha-protocadherin-gamma complex
created_by: midori
creation_date: 2009-11-23T04:22:08Z

[Term]
id: GO:0071188
name: protocadherin-alpha-v7-protocadherin-gamma-a1 complex
namespace: cellular_component
def: "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-a1, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688]
synonym: "Pcdha7-Pcdhga1 complex" NARROW [CORUM:1021]
is_a: GO:0071183 ! protocadherin-alpha-protocadherin-gamma complex
created_by: midori
creation_date: 2009-11-23T04:23:25Z

[Term]
id: GO:0071189
name: protocadherin-alpha-v7-protocadherin-gamma-a3 complex
namespace: cellular_component
def: "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-a3, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688]
synonym: "Pcdha7-Pcdhga3 complex" NARROW [CORUM:1019]
is_a: GO:0071183 ! protocadherin-alpha-protocadherin-gamma complex
created_by: midori
creation_date: 2009-11-23T04:24:28Z

[Term]
id: GO:0071190
name: protocadherin-alpha-v7-protocadherin-gamma-b2 complex
namespace: cellular_component
def: "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-b2, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688]
synonym: "Pcdha7-Pcdhgb4 complex" NARROW [CORUM:1018]
is_a: GO:0071183 ! protocadherin-alpha-protocadherin-gamma complex
created_by: midori
creation_date: 2009-11-23T04:30:12Z

[Term]
id: GO:0071191
name: protocadherin-alpha-v7-protocadherin-gamma-b4 complex
namespace: cellular_component
def: "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-b4, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688]
synonym: "Pcdha7-Pcdhgb2 complex" NARROW [CORUM:1020]
is_a: GO:0071183 ! protocadherin-alpha-protocadherin-gamma complex
created_by: midori
creation_date: 2009-11-23T04:30:51Z

[Term]
id: GO:0071192
name: Kv4.2-KChIP1 channel complex
namespace: cellular_component
def: "A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP1 associated with the channel via interaction with the Kv alpha subunit 4.2." [PMID:15356203]
xref: CORUM:606
is_a: GO:0008076 ! voltage-gated potassium channel complex
created_by: midori
creation_date: 2009-11-23T04:51:42Z

[Term]
id: GO:0071193
name: Kv4.2-KChIP2 channel complex
namespace: cellular_component
def: "A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP2 associated with the channel via interaction with the Kv alpha subunit 4.2." [PMID:15356203]
xref: CORUM:607
is_a: GO:0008076 ! voltage-gated potassium channel complex
created_by: midori
creation_date: 2009-11-23T04:58:09Z

[Term]
id: GO:0071194
name: Kv4.2-KChIP3 channel complex
namespace: cellular_component
def: "A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP3 associated with the channel via interaction with the Kv alpha subunit 4.2." [PMID:15356203]
xref: CORUM:608
is_a: GO:0008076 ! voltage-gated potassium channel complex
created_by: midori
creation_date: 2009-11-23T04:58:41Z

[Term]
id: GO:0071195
name: Kv4.2-KChIP4 channel complex
namespace: cellular_component
def: "A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP4 associated with the channel via interaction with the Kv alpha subunit 4.2." [PMID:15356203]
xref: CORUM:3090
is_a: GO:0008076 ! voltage-gated potassium channel complex
created_by: midori
creation_date: 2009-11-23T04:59:06Z

[Term]
id: GO:0071196
name: Kv4.3-KChIP1 channel complex
namespace: cellular_component
def: "A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP1 associated with the channel via interaction with the Kv alpha subunit 4.3." [PMID:15356203]
xref: CORUM:3091
is_a: GO:0008076 ! voltage-gated potassium channel complex
created_by: midori
creation_date: 2009-11-23T04:59:38Z

[Term]
id: GO:0071197
name: Kv4.2-Kv4.3 channel complex
namespace: cellular_component
def: "A voltage-gated potassium channel complex that contains the Kv alpha subunits 4.2 and 4.3." [PMID:15356203]
xref: CORUM:609
is_a: GO:0008076 ! voltage-gated potassium channel complex
created_by: midori
creation_date: 2009-11-23T05:00:33Z

[Term]
id: GO:0071198
name: Kv4.1-DPP6 channel complex
namespace: cellular_component
def: "A voltage-gated potassium channel complex that contains the peptidase-related protein DPP6 associated with the channel via interaction with the Kv alpha subunit 4.1." [PMID:15911355]
synonym: "Kv4.1-DPPX channel complex" EXACT [PMID:15911355]
xref: CORUM:600
is_a: GO:0008076 ! voltage-gated potassium channel complex
created_by: midori
creation_date: 2009-11-23T05:14:37Z

[Term]
id: GO:0071199
name: Kv4.1-DPP10 channel complex
namespace: cellular_component
def: "A voltage-gated potassium channel complex that contains the peptidase-related protein DPP10 associated with the channel via interaction with the Kv alpha subunit 4.1." [PMID:15911355]
synonym: "Kv4.1-DPPY channel complex" EXACT [PMID:15911355]
xref: CORUM:601
is_a: GO:0008076 ! voltage-gated potassium channel complex
created_by: midori
creation_date: 2009-11-23T05:17:50Z

[Term]
id: GO:0071200
name: Kv4.2-DPP6 channel complex
namespace: cellular_component
def: "A voltage-gated potassium channel complex that contains the peptidase-related protein DPP6 associated with the channel via interaction with the Kv alpha subunit 4.2." [PMID:12575952, PMID:15911355]
synonym: "Kv4.2-DPPX channel complex" EXACT [PMID:15911355]
xref: CORUM:603
is_a: GO:0008076 ! voltage-gated potassium channel complex
created_by: midori
creation_date: 2009-11-23T05:18:31Z

[Term]
id: GO:0071201
name: Kv4.3-DPP6 channel complex
namespace: cellular_component
def: "A voltage-gated potassium channel complex that contains the peptidase-related protein DPP6 associated with the channel via interaction with the Kv alpha subunit 4.3." [PMID:12575952, PMID:15911355]
synonym: "Kv4.3-DPPX channel complex" EXACT [PMID:15911355]
xref: CORUM:599
is_a: GO:0008076 ! voltage-gated potassium channel complex
created_by: midori
creation_date: 2009-11-23T05:20:54Z

[Term]
id: GO:0071202
name: Kv4.3-DPP10 channel complex
namespace: cellular_component
def: "A voltage-gated potassium channel complex that contains the peptidase-related protein DPP10 associated with the channel via interaction with the Kv alpha subunit 4.3." [PMID:15911355]
synonym: "Kv4.3-DPPY channel complex" EXACT [PMID:15911355]
xref: CORUM:598
is_a: GO:0008076 ! voltage-gated potassium channel complex
created_by: midori
creation_date: 2009-11-23T05:21:37Z

[Term]
id: GO:0071203
name: WASH complex
namespace: cellular_component
def: "A protein complex that localizes at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization. In human, the WASH complex is composed of F-actin-capping protein subunits alpha and beta, WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53." [GOC:sp, PMID:19922875]
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part
created_by: midori
creation_date: 2009-11-25T11:01:33Z

[Term]
id: GO:0071204
name: histone pre-mRNA 3'end processing complex
namespace: cellular_component
def: "A ribonucleoprotein that binds to specific sites in, and is required for cleavage of, the 3'-end of histone pre-mRNAs. The complex contains the U7 snRNP and additional proteins, including the stem-loop binding protein (SLBP) and the exonuclease 3'hExo/Eri-1." [GOC:mah, PMID:19470752]
synonym: "histone 3'end pre-mRNA complex" EXACT [GOC:mah]
is_a: GO:0030529 ! intracellular ribonucleoprotein complex
is_a: GO:0044428 ! nuclear part
created_by: midori
creation_date: 2009-11-25T11:11:02Z

[Term]
id: GO:0071205
name: protein localization to juxtaparanode region of axon
namespace: biological_process
def: "Any process in which a protein is transported to, or maintained at, the juxtaparanode region of an axon." [GOC:BHF, GOC:mah]
synonym: "protein localisation to juxtaparanode region of axon" EXACT [GOC:mah]
is_a: GO:0034613 ! cellular protein localization
is_a: GO:0099612 ! protein localization to axon
created_by: midori
creation_date: 2009-11-25T01:13:55Z

[Term]
id: GO:0071206
name: establishment of protein localization to juxtaparanode region of axon
namespace: biological_process
def: "The directed movement of a protein to the juxtaparanode region of an axon." [GOC:BHF, GOC:mah]
synonym: "establishment of protein localisation to juxtaparanode region of axon" EXACT [GOC:mah]
is_a: GO:0045184 ! establishment of protein localization
relationship: part_of GO:0071205 ! protein localization to juxtaparanode region of axon
created_by: midori
creation_date: 2009-11-25T01:15:23Z

[Term]
id: GO:0071207
name: histone pre-mRNA stem-loop binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a conserved stem-loop structure found in histone pre-mRNAs." [PMID:19470752]
is_a: GO:0036002 ! pre-mRNA binding
created_by: midori
creation_date: 2009-11-25T01:25:15Z

[Term]
id: GO:0071208
name: histone pre-mRNA DCP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the downstream cleavage product (DCP) generated by histone pre-mRNA 3'-end processing." [PMID:19470752]
is_a: GO:0003723 ! RNA binding
created_by: midori
creation_date: 2009-11-25T01:41:35Z

[Term]
id: GO:0071209
name: U7 snRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the U7 small nuclear RNA (U7 snRNA)." [GOC:mah, PMID:12975319]
comment: Note that this term may be useful for annotating other small nuclear RNAs (snRNAs).
is_a: GO:0017069 ! snRNA binding
created_by: midori
creation_date: 2009-11-25T01:46:50Z

[Term]
id: GO:0071210
name: protein insertion into membrane raft
namespace: biological_process
def: "The process in which a protein is incorporated into a membrane raft. Membrane rafts are small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes." [GOC:mah]
synonym: "establishment of protein localization to membrane raft" BROAD [GOC:mah, GOC:vw]
is_a: GO:0051205 ! protein insertion into membrane
relationship: part_of GO:0031579 ! membrane raft organization
created_by: midori
creation_date: 2009-11-25T02:11:46Z

[Term]
id: GO:0071211
name: protein targeting to vacuole involved in autophagy
namespace: biological_process
def: "The process of directing proteins towards the vacuole using signals contained within the protein, occurring as part of autophagy, the process in which cells digest parts of their own cytoplasm." [GOC:mah]
synonym: "protein targeting to autophagosome" RELATED [GOC:pad]
is_a: GO:0006623 ! protein targeting to vacuole
intersection_of: GO:0006623 ! protein targeting to vacuole
intersection_of: part_of GO:0006914 ! autophagy
relationship: part_of GO:0006914 ! autophagy
created_by: midori
creation_date: 2009-11-25T02:25:27Z

[Term]
id: GO:0071212
name: subsynaptic reticulum
namespace: cellular_component
def: "An elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane." [PMID:1460464, PMID:18171947, PMID:19244343, PMID:7946331]
synonym: "SSR" EXACT [PMID:19244343]
is_a: GO:0033267 ! axon part
is_a: GO:0043231 ! intracellular membrane-bounded organelle
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0044456 ! synapse part
relationship: part_of GO:0061174 ! type I terminal bouton
created_by: midori
creation_date: 2009-12-01T05:05:21Z

[Term]
id: GO:0071213
name: cellular response to 1-aminocyclopropane-1-carboxylic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-aminocyclopropane-1-carboxylic acid stimulus." [GOC:mah]
is_a: GO:0009961 ! response to 1-aminocyclopropane-1-carboxylic acid
is_a: GO:0071230 ! cellular response to amino acid stimulus
created_by: midori
creation_date: 2009-12-03T12:10:11Z

[Term]
id: GO:0071214
name: cellular response to abiotic stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
subset: gosubset_prok
synonym: "cellular response to abiotic stress" NARROW [GOC:mah]
is_a: GO:0009628 ! response to abiotic stimulus
is_a: GO:0051716 ! cellular response to stimulus
created_by: midori
creation_date: 2009-12-03T01:02:11Z

[Term]
id: GO:0071215
name: cellular response to abscisic acid stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus." [GOC:mah]
is_a: GO:0009737 ! response to abscisic acid
is_a: GO:0032870 ! cellular response to hormone stimulus
is_a: GO:0071229 ! cellular response to acid chemical
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:0097306 ! cellular response to alcohol
created_by: midori
creation_date: 2009-12-03T01:04:18Z

[Term]
id: GO:0071216
name: cellular response to biotic stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
synonym: "cellular response to biotic stress" NARROW [GOC:mah]
is_a: GO:0009607 ! response to biotic stimulus
is_a: GO:0051716 ! cellular response to stimulus
created_by: midori
creation_date: 2009-12-03T01:09:08Z

[Term]
id: GO:0071217
name: cellular response to external biotic stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things." [GOC:mah]
is_a: GO:0043207 ! response to external biotic stimulus
is_a: GO:0071216 ! cellular response to biotic stimulus
is_a: GO:0071496 ! cellular response to external stimulus
created_by: midori
creation_date: 2009-12-03T01:14:27Z

[Term]
id: GO:0071218
name: cellular response to misfolded protein
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus." [GOC:mah]
is_a: GO:0035967 ! cellular response to topologically incorrect protein
is_a: GO:0051788 ! response to misfolded protein
created_by: midori
creation_date: 2009-12-03T01:17:46Z

[Term]
id: GO:0071219
name: cellular response to molecule of bacterial origin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin." [GOC:mah]
synonym: "cellular response to bacteria associated molecule" EXACT [GOC:mah]
synonym: "cellular response to bacterial associated molecule" EXACT [GOC:mah]
synonym: "cellular response to bacterium associated molecule" EXACT [GOC:mah]
is_a: GO:0002237 ! response to molecule of bacterial origin
is_a: GO:0071216 ! cellular response to biotic stimulus
created_by: midori
creation_date: 2009-12-03T01:22:00Z

[Term]
id: GO:0071220
name: cellular response to bacterial lipoprotein
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacterial lipoprotein stimulus." [GOC:mah]
is_a: GO:0032493 ! response to bacterial lipoprotein
is_a: GO:0071219 ! cellular response to molecule of bacterial origin
created_by: midori
creation_date: 2009-12-03T01:26:36Z

[Term]
id: GO:0071221
name: cellular response to bacterial lipopeptide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacterial lipopeptide stimulus." [GOC:mah]
is_a: GO:0070339 ! response to bacterial lipopeptide
is_a: GO:0071220 ! cellular response to bacterial lipoprotein
created_by: midori
creation_date: 2009-12-03T01:28:03Z

[Term]
id: GO:0071222
name: cellular response to lipopolysaccharide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria." [GOC:mah]
synonym: "cellular response to endotoxin" BROAD [GOC:mah, GOC:sl]
synonym: "cellular response to LPS" EXACT [GOC:mah]
is_a: GO:0032496 ! response to lipopolysaccharide
is_a: GO:0071219 ! cellular response to molecule of bacterial origin
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: midori
creation_date: 2009-12-03T01:29:29Z

[Term]
id: GO:0071223
name: cellular response to lipoteichoic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoteichoic acid stimulus; lipoteichoic acid is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor." [GOC:mah]
synonym: "cellular response to LTA" EXACT [GOC:mah]
is_a: GO:0070391 ! response to lipoteichoic acid
is_a: GO:0071219 ! cellular response to molecule of bacterial origin
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: midori
creation_date: 2009-12-03T01:31:00Z

[Term]
id: GO:0071224
name: cellular response to peptidoglycan
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidoglycan stimulus. Peptidoglycan is a bacterial cell wall macromolecule." [GOC:mah]
is_a: GO:0032494 ! response to peptidoglycan
is_a: GO:0071219 ! cellular response to molecule of bacterial origin
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: midori
creation_date: 2009-12-03T01:36:38Z

[Term]
id: GO:0071225
name: cellular response to muramyl dipeptide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan." [GOC:mah]
is_a: GO:0032495 ! response to muramyl dipeptide
is_a: GO:1901653 ! cellular response to peptide
created_by: midori
creation_date: 2009-12-03T01:41:23Z

[Term]
id: GO:0071226
name: cellular response to molecule of fungal origin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of fungal origin such as chito-octamer oligosaccharide." [GOC:mah]
synonym: "cellular response to fungus associated molecule" EXACT [GOC:mah]
is_a: GO:0002238 ! response to molecule of fungal origin
is_a: GO:0071216 ! cellular response to biotic stimulus
created_by: midori
creation_date: 2009-12-03T01:50:01Z

[Term]
id: GO:0071227
name: cellular response to molecule of oomycetes origin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of oomycetes origin." [GOC:mah]
synonym: "cellular response to oomycetes associated molecule" EXACT [GOC:mah]
is_a: GO:0002240 ! response to molecule of oomycetes origin
is_a: GO:0071216 ! cellular response to biotic stimulus
is_a: GO:0071310 ! cellular response to organic substance
relationship: part_of GO:0009620 ! response to fungus
created_by: midori
creation_date: 2009-12-03T01:55:09Z

[Term]
id: GO:0071228
name: cellular response to tumor cell
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a tumor cell." [GOC:mah]
is_a: GO:0002347 ! response to tumor cell
is_a: GO:0071216 ! cellular response to biotic stimulus
created_by: midori
creation_date: 2009-12-03T02:04:43Z

[Term]
id: GO:0071229
name: cellular response to acid chemical
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of the dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form." [GOC:go_curators, GOC:mah, http://en.wikipedia.org/wiki/Acid]
comment: This term should be used to describe a response to a specific acid as a chemical. E.g., if a cell were responding to glutamate, then the response would be glutamate-specific; the cell is actually responding to the chemical structure of the anion portion of the dissociated acid. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. If annotating experiments where an acid is playing a role as a proton donor, please annotate to GO:0071468 'cellular response to acidic pH' instead.
subset: gocheck_do_not_manually_annotate
synonym: "cellular response to acid" BROAD []
synonym: "cellular response to acid anion" RELATED []
synonym: "cellular response to oxoanion" RELATED []
is_a: GO:0001101 ! response to acid chemical
is_a: GO:0070887 ! cellular response to chemical stimulus
created_by: midori
creation_date: 2009-12-03T02:07:23Z

[Term]
id: GO:0071230
name: cellular response to amino acid stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups." [CHEBI:33709, GOC:mah]
synonym: "cellular response to amino acid" EXACT [GOC:mah]
is_a: GO:0043200 ! response to amino acid
is_a: GO:0071229 ! cellular response to acid chemical
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: midori
creation_date: 2009-12-03T02:08:11Z

[Term]
id: GO:0071231
name: cellular response to folic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a folic acid stimulus." [GOC:mah]
synonym: "response to folate" EXACT [GOC:mah]
synonym: "response to vitamin B9" EXACT [GOC:mah]
is_a: GO:0051593 ! response to folic acid
is_a: GO:0071230 ! cellular response to amino acid stimulus
is_a: GO:0071295 ! cellular response to vitamin
is_a: GO:0071407 ! cellular response to organic cyclic compound
created_by: midori
creation_date: 2009-12-03T02:08:32Z

[Term]
id: GO:0071232
name: cellular response to histidine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histidine stimulus." [GOC:mah]
is_a: GO:0071230 ! cellular response to amino acid stimulus
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0080052 ! response to histidine
created_by: midori
creation_date: 2009-12-03T02:09:15Z

[Term]
id: GO:0071233
name: cellular response to leucine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leucine stimulus." [GOC:mah]
is_a: GO:0043201 ! response to leucine
is_a: GO:0071230 ! cellular response to amino acid stimulus
created_by: midori
creation_date: 2009-12-03T02:09:26Z

[Term]
id: GO:0071234
name: cellular response to phenylalanine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phenylalanine stimulus." [GOC:mah]
is_a: GO:0071230 ! cellular response to amino acid stimulus
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0080053 ! response to phenylalanine
created_by: midori
creation_date: 2009-12-03T02:09:36Z

[Term]
id: GO:0071235
name: cellular response to proline
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a proline stimulus." [GOC:mah]
is_a: GO:0010238 ! response to proline
is_a: GO:0071230 ! cellular response to amino acid stimulus
is_a: GO:0071407 ! cellular response to organic cyclic compound
created_by: midori
creation_date: 2009-12-03T02:09:45Z

[Term]
id: GO:0071236
name: cellular response to antibiotic
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms." [GOC:mah]
subset: gosubset_prok
is_a: GO:0046677 ! response to antibiotic
is_a: GO:0097237 ! cellular response to toxic substance
created_by: midori
creation_date: 2009-12-03T02:23:49Z

[Term]
id: GO:0071237
name: cellular response to bacteriocin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacteriocin stimulus. A bacteriocin is a protein substance released by certain bacteria that kills but does not lyse closely related strains of bacteria. Specific bacteriocins attach to specific receptors on cell walls and induce specific metabolic block, e.g. cessation of nucleic acid or protein synthesis of oxidative phosphorylation." [GOC:mah]
subset: gosubset_prok
is_a: GO:0046678 ! response to bacteriocin
is_a: GO:0071236 ! cellular response to antibiotic
is_a: GO:1901653 ! cellular response to peptide
created_by: midori
creation_date: 2009-12-03T02:25:43Z

[Term]
id: GO:0071238
name: cellular response to brefeldin A
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brefeldin A stimulus." [GOC:mah]
is_a: GO:0031001 ! response to brefeldin A
is_a: GO:0071236 ! cellular response to antibiotic
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: midori
creation_date: 2009-12-03T02:25:52Z

[Term]
id: GO:0071239
name: cellular response to streptomycin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a streptomycin stimulus. Streptomycin is a commonly used antibiotic in cell culture media which acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome." [GOC:mah]
is_a: GO:0046679 ! response to streptomycin
is_a: GO:0071236 ! cellular response to antibiotic
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: midori
creation_date: 2009-12-03T02:25:59Z

[Term]
id: GO:0071240
name: cellular response to food
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a food stimulus; food is anything which, when taken into the body, serves to nourish or build up the tissues or to supply body heat." [GOC:mah]
is_a: GO:0032094 ! response to food
is_a: GO:0070887 ! cellular response to chemical stimulus
created_by: midori
creation_date: 2009-12-03T02:28:35Z

[Term]
id: GO:0071241
name: cellular response to inorganic substance
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus." [GOC:mah]
subset: gosubset_prok
is_a: GO:0010035 ! response to inorganic substance
is_a: GO:0070887 ! cellular response to chemical stimulus
created_by: midori
creation_date: 2009-12-03T02:35:49Z

[Term]
id: GO:0071242
name: cellular response to ammonium ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium ion stimulus." [GOC:mah]
is_a: GO:0060359 ! response to ammonium ion
is_a: GO:1901699 ! cellular response to nitrogen compound
created_by: midori
creation_date: 2009-12-03T02:39:40Z

[Term]
id: GO:0071243
name: cellular response to arsenic-containing substance
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides." [GOC:mah]
subset: gosubset_prok
synonym: "cellular response to arsenic" EXACT [GOC:curators]
is_a: GO:0046685 ! response to arsenic-containing substance
is_a: GO:0070887 ! cellular response to chemical stimulus
created_by: midori
creation_date: 2009-12-03T02:41:05Z

[Term]
id: GO:0071244
name: cellular response to carbon dioxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon dioxide (CO2) stimulus." [GOC:mah]
is_a: GO:0010037 ! response to carbon dioxide
is_a: GO:0071241 ! cellular response to inorganic substance
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: midori
creation_date: 2009-12-03T02:41:21Z

[Term]
id: GO:0071245
name: cellular response to carbon monoxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon monoxide (CO) stimulus." [GOC:mah]
is_a: GO:0034465 ! response to carbon monoxide
is_a: GO:0071241 ! cellular response to inorganic substance
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: midori
creation_date: 2009-12-03T02:44:43Z

[Term]
id: GO:0071246
name: cellular response to chlorate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chlorate stimulus." [GOC:mah]
is_a: GO:0010157 ! response to chlorate
is_a: GO:0071229 ! cellular response to acid chemical
is_a: GO:0071241 ! cellular response to inorganic substance
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: midori
creation_date: 2009-12-03T02:45:36Z

[Term]
id: GO:0071247
name: cellular response to chromate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chromate stimulus." [GOC:mah]
subset: gosubset_prok
is_a: GO:0046687 ! response to chromate
is_a: GO:0071241 ! cellular response to inorganic substance
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: midori
creation_date: 2009-12-03T02:46:01Z

[Term]
id: GO:0071248
name: cellular response to metal ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:mah]
subset: gosubset_prok
synonym: "cellular response to heavy metal" NARROW [GOC:mah]
synonym: "cellular response to metal" EXACT [GOC:mah]
is_a: GO:0010038 ! response to metal ion
is_a: GO:0071241 ! cellular response to inorganic substance
created_by: midori
creation_date: 2009-12-03T02:46:31Z

[Term]
id: GO:0071249
name: cellular response to nitrate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrate stimulus." [GOC:mah]
is_a: GO:0010167 ! response to nitrate
is_a: GO:0071229 ! cellular response to acid chemical
is_a: GO:0071241 ! cellular response to inorganic substance
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1902170 ! cellular response to reactive nitrogen species
created_by: midori
creation_date: 2009-12-03T03:02:06Z

[Term]
id: GO:0071250
name: cellular response to nitrite
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrate stimulus." [GOC:mah]
is_a: GO:0071229 ! cellular response to acid chemical
is_a: GO:0071241 ! cellular response to inorganic substance
is_a: GO:0080033 ! response to nitrite
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1902170 ! cellular response to reactive nitrogen species
created_by: midori
creation_date: 2009-12-03T03:03:49Z

[Term]
id: GO:0071251
name: cellular response to silicon dioxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a silicon dioxide stimulus." [GOC:mah]
synonym: "cellular response to silica" EXACT [GOC:mah]
synonym: "cellular response to silox" EXACT [GOC:mah]
is_a: GO:0034021 ! response to silicon dioxide
is_a: GO:0071241 ! cellular response to inorganic substance
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: midori
creation_date: 2009-12-03T03:09:41Z

[Term]
id: GO:0071252
name: cellular response to sulfur dioxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sulfur dioxide (SO2) stimulus." [GOC:mah]
is_a: GO:0010477 ! response to sulfur dioxide
is_a: GO:0071241 ! cellular response to inorganic substance
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: midori
creation_date: 2009-12-03T03:10:16Z

[Term]
id: GO:0071253
name: connexin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a connexin, any of a group of related proteins that assemble to form gap junctions." [GOC:mah, PMID:19864490]
is_a: GO:0005515 ! protein binding
created_by: midori
creation_date: 2009-12-04T10:07:54Z

[Term]
id: GO:0071254
name: cytoplasmic U snRNP body
namespace: cellular_component
def: "A ribonucleoprotein complex that can be visualized as a focus in the cytoplasm, and contains uridine-rich small nuclear ribonucleoproteins (U snRNPs) and essential snRNP assembly factors. These U bodies are invariably found in association with P bodies." [GOC:sart, PMID:17595295]
synonym: "U body" EXACT [GOC:sart, PMID:17595295]
synonym: "U-body" EXACT [GOC:mah]
is_a: GO:0030529 ! intracellular ribonucleoprotein complex
is_a: GO:0044444 ! cytoplasmic part
created_by: midori
creation_date: 2009-12-04T10:31:29Z

[Term]
id: GO:0071255
name: CVT vesicle assembly
namespace: biological_process
def: "A vesicle organization process that takes place as part of the CVT pathway, and results in the formation of a double membrane-bounded cytosolic structure that sequesters precursor aminopeptidase I (prAPI)." [GOC:rb, PMID:10966461, PMID:11085977]
synonym: "CVT vesicle biosynthesis" RELATED [GOC:mah]
synonym: "CVT vesicle formation" EXACT [GOC:mah]
is_a: GO:0016050 ! vesicle organization
is_a: GO:0070925 ! organelle assembly
relationship: part_of GO:0032258 ! CVT pathway
created_by: midori
creation_date: 2009-12-04T10:39:50Z

[Term]
id: GO:0071256
name: translocon complex
namespace: cellular_component
alt_id: GO:0031206
def: "A protein complex that constitutes a specific site of protein translocation across the endoplasmic reticulum, which involves the signal recognition particle receptor. The complex contains a core heterotrimer of alpha, beta and gamma subunits, and may contain additional proteins." [GOC:mah, PMID:10611978, PMID:18166647, PMID:8612571]
synonym: "Sec complex-associated translocon complex" NARROW [GOC:mah]
is_a: GO:0044432 ! endoplasmic reticulum part
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0030867 ! rough endoplasmic reticulum membrane
created_by: midori
creation_date: 2009-12-08T02:08:03Z

[Term]
id: GO:0071257
name: cellular response to electrical stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus." [GOC:mah]
synonym: "cellular response to electricity" RELATED [GOC:mah]
is_a: GO:0051602 ! response to electrical stimulus
is_a: GO:0071214 ! cellular response to abiotic stimulus
created_by: midori
creation_date: 2009-12-04T03:27:03Z

[Term]
id: GO:0071258
name: cellular response to gravity
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus." [GOC:mah]
synonym: "cellular response to gravitational stimulus" EXACT [GOC:mah]
is_a: GO:0009629 ! response to gravity
is_a: GO:0071214 ! cellular response to abiotic stimulus
created_by: midori
creation_date: 2009-12-04T03:31:36Z

[Term]
id: GO:0071259
name: cellular response to magnetism
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnetic stimulus." [GOC:mah]
synonym: "cellular response to magnetic stimulus" EXACT [GOC:mah]
is_a: GO:0071000 ! response to magnetism
is_a: GO:0071214 ! cellular response to abiotic stimulus
created_by: midori
creation_date: 2009-12-04T03:54:53Z

[Term]
id: GO:0071260
name: cellular response to mechanical stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus." [GOC:mah]
synonym: "cellular mechanical stimulus response" EXACT [GOC:mah]
is_a: GO:0009612 ! response to mechanical stimulus
is_a: GO:0071214 ! cellular response to abiotic stimulus
is_a: GO:0071496 ! cellular response to external stimulus
created_by: midori
creation_date: 2009-12-04T03:55:44Z

[Term]
id: GO:0071261
name: Ssh1 translocon complex
namespace: cellular_component
def: "A translocon complex that contains a core heterotrimer of alpha, beta and gamma subunits, and may contain additional proteins (translocon-associated proteins or TRAPs); in budding yeast the core proteins are Ssh1p, Sbh2p, and Sss1p. The Ssh1 translocon complex is involved in the cotranslational pathway of protein transport across the ER membrane, and recognizes proteins bearing strongly hydrophobic signal sequences." [GOC:mah, PMID:12134063, PMID:8612571]
synonym: "Ssh1p-Sss1p-Sbh2p complex" NARROW [GOC:mah]
is_a: GO:0071256 ! translocon complex
created_by: midori
creation_date: 2009-12-08T02:22:55Z

[Term]
id: GO:0071262
name: regulation of translational initiation in response to starvation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of translation initiation, as a result of deprivation of nourishment." [GOC:mah]
synonym: "regulation of translational initiation in response to nutrient starvation" EXACT [GOC:vw]
is_a: GO:0009267 ! cellular response to starvation
is_a: GO:0043558 ! regulation of translational initiation in response to stress
created_by: midori
creation_date: 2009-12-08T05:31:05Z

[Term]
id: GO:0071263
name: negative regulation of translational initiation in response to starvation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate of translation initiation, as a result of deprivation of nourishment." [GOC:mah]
synonym: "down regulation of translation initiation in response to starvation" EXACT [GOC:mah]
synonym: "down-regulation of translation initiation in response to starvation" EXACT [GOC:mah]
synonym: "downregulation of translation initiation in response to starvation" EXACT [GOC:mah]
synonym: "inhibition of translation initiation in response to starvation" NARROW [GOC:mah]
synonym: "negative regulation of translational initiation in response to nutrient starvation" EXACT [GOC:vw]
is_a: GO:0032057 ! negative regulation of translational initiation in response to stress
is_a: GO:0071262 ! regulation of translational initiation in response to starvation
created_by: midori
creation_date: 2009-12-08T05:33:12Z

[Term]
id: GO:0071264
name: positive regulation of translational initiation in response to starvation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of translation initiation, as a result of deprivation of nourishment." [GOC:mah]
synonym: "activation of translation initiation in response to starvation" NARROW [GOC:mah]
synonym: "positive regulation of translational initiation in response to nutrient starvation" EXACT [GOC:mah]
synonym: "stimulation of translation initiation in response to starvation" NARROW [GOC:mah]
synonym: "up regulation of translation initiation in response to starvation" EXACT [GOC:mah]
synonym: "up-regulation of translation initiation in response to starvation" EXACT [GOC:mah]
synonym: "upregulation of translation initiation in response to starvation" EXACT [GOC:mah]
is_a: GO:0032058 ! positive regulation of translational initiation in response to stress
is_a: GO:0071262 ! regulation of translational initiation in response to starvation
created_by: midori
creation_date: 2009-12-08T05:35:45Z

[Term]
id: GO:0071265
name: L-methionine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-methionine, the L-enantiomer of (2S)-2-amino-4-(methylsulfanyl)butanoic acid." [CHEBI:16643, GOC:ecd]
synonym: "L-methionine anabolism" EXACT [GOC:mah]
synonym: "L-methionine biosynthesis" EXACT [GOC:mah]
synonym: "L-methionine formation" EXACT [GOC:mah]
synonym: "L-methionine synthesis" EXACT [GOC:mah]
is_a: GO:0009086 ! methionine biosynthetic process
created_by: midori
creation_date: 2009-12-09T04:28:15Z

[Term]
id: GO:0071266
name: 'de novo' L-methionine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-methionine, the L-enantiomer of (2S)-2-amino-4-(methylsulfanyl)butanoic acid, from simpler components." [CHEBI:16643, GOC:ecd]
synonym: "'de novo' L-methionine anabolism" EXACT [GOC:mah]
synonym: "'de novo' L-methionine biosynthesis" EXACT [GOC:mah]
synonym: "'de novo' L-methionine formation" EXACT [GOC:mah]
synonym: "'de novo' L-methionine synthesis" EXACT [GOC:mah]
is_a: GO:0071265 ! L-methionine biosynthetic process
created_by: midori
creation_date: 2009-12-09T04:34:41Z

[Term]
id: GO:0071267
name: L-methionine salvage
namespace: biological_process
def: "Any process that generates L-methionine from derivatives of it, without de novo synthesis." [CHEBI:16643, GOC:ecd]
is_a: GO:0043102 ! amino acid salvage
is_a: GO:0071265 ! L-methionine biosynthetic process
created_by: midori
creation_date: 2009-12-09T04:36:49Z

[Term]
id: GO:0071268
name: homocysteine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of homocysteine, 2-amino-4-sulfanylbutanoic acid." [CHEBI:17230, GOC:ecd, GOC:mah]
synonym: "homocysteine anabolism" EXACT [GOC:mah]
synonym: "homocysteine biosynthesis" EXACT [GOC:mah]
synonym: "homocysteine formation" EXACT [GOC:mah]
synonym: "homocysteine synthesis" EXACT [GOC:mah]
is_a: GO:0000097 ! sulfur amino acid biosynthetic process
is_a: GO:0042398 ! cellular modified amino acid biosynthetic process
is_a: GO:0050667 ! homocysteine metabolic process
is_a: GO:1901607 ! alpha-amino acid biosynthetic process
created_by: midori
creation_date: 2009-12-09T05:32:48Z

[Term]
id: GO:0071269
name: L-homocysteine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-homocysteine, the L-enantiomer of 2-amino-4-sulfanylbutanoic acid." [CHEBI:17588, GOC:ecd, GOC:mah]
synonym: "L-homocysteine anabolism" EXACT [GOC:mah]
synonym: "L-homocysteine biosynthesis" EXACT [GOC:mah]
synonym: "L-homocysteine formation" EXACT [GOC:mah]
synonym: "L-homocysteine synthesis" EXACT [GOC:mah]
is_a: GO:0009070 ! serine family amino acid biosynthetic process
is_a: GO:0071268 ! homocysteine biosynthetic process
created_by: midori
creation_date: 2009-12-09T05:36:37Z

[Term]
id: GO:0071270
name: 1-butanol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 1-butanol, an alkyl primary alcohol with the formula C4H10O." [CHEBI:28885, GOC:ecd, GOC:mah]
synonym: "1-butanol metabolism" EXACT [GOC:mah]
synonym: "butan-1-ol metabolic process" EXACT [CHEBI:28885]
synonym: "butanol metabolic process" BROAD [GOC:mah]
is_a: GO:0034308 ! primary alcohol metabolic process
created_by: midori
creation_date: 2009-12-10T10:23:11Z

[Term]
id: GO:0071271
name: 1-butanol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 1-butanol, an alkyl primary alcohol with the formula C4H10O." [CHEBI:28885, GOC:ecd, GOC:mah]
synonym: "1-butanol anabolism" EXACT [GOC:mah]
synonym: "1-butanol biosynthesis" EXACT [GOC:mah]
synonym: "1-butanol formation" EXACT [GOC:mah]
synonym: "1-butanol synthesis" EXACT [GOC:mah]
synonym: "butan-1-ol biosynthetic process" EXACT [CHEBI:28885]
synonym: "butanol biosynthetic process" BROAD [GOC:mah]
is_a: GO:0034309 ! primary alcohol biosynthetic process
is_a: GO:0071270 ! 1-butanol metabolic process
created_by: midori
creation_date: 2009-12-10T10:27:24Z

[Term]
id: GO:0071272
name: morphine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving morphine, 17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol. Morphine is a highly potent opiate analgesic psychoactive drug obtained form the opium poppy, Papaver somniferum." [CHEBI:17303, GOC:mah]
subset: gosubset_prok
synonym: "morphine metabolism" EXACT [GOC:mah]
xref: Wikipedia:Morphine
is_a: GO:0033076 ! isoquinoline alkaloid metabolic process
is_a: GO:0097164 ! ammonium ion metabolic process
is_a: GO:1901376 ! organic heteropentacyclic compound metabolic process
created_by: midori
creation_date: 2009-12-10T11:11:51Z

[Term]
id: GO:0071273
name: morphine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of morphine, 17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol. Morphine is a highly potent opiate analgesic psychoactive drug obtained form the opium poppy, Papaver somniferum." [CHEBI:17303, GOC:ecd, GOC:mah]
subset: gosubset_prok
synonym: "morphine breakdown" EXACT [GOC:mah]
synonym: "morphine catabolism" EXACT [GOC:mah]
synonym: "morphine degradation" EXACT [GOC:mah]
xref: UniPathway:Q02198
is_a: GO:0071272 ! morphine metabolic process
is_a: GO:0071274 ! isoquinoline alkaloid catabolic process
is_a: GO:1901377 ! organic heteropentacyclic compound catabolic process
created_by: midori
creation_date: 2009-12-10T11:16:28Z

[Term]
id: GO:0071274
name: isoquinoline alkaloid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of isoquinoline alkaloids, alkaloid compounds that contain bicyclic N-containing aromatic rings and are derived from a 3,4-dihydroxytyramine (dopamine) precursor that undergoes a Schiff base addition with aldehydes of different origin." [GOC:mah, http://www.life.uiuc.edu/ib/425/lecture32.html]
subset: gosubset_prok
synonym: "ipecac alkaloid catabolism" RELATED [GOC:mah]
synonym: "isoquinoline alkaloid breakdown" EXACT [GOC:mah]
synonym: "isoquinoline alkaloid catabolism" EXACT [GOC:mah]
synonym: "isoquinoline alkaloid degradation" EXACT [GOC:mah]
is_a: GO:0009822 ! alkaloid catabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0033076 ! isoquinoline alkaloid metabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
created_by: midori
creation_date: 2009-12-10T11:17:49Z

[Term]
id: GO:0071275
name: cellular response to aluminum ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aluminum ion stimulus." [GOC:mah]
synonym: "cellular response to aluminium ion" EXACT [GOC:mah]
synonym: "cellular response to aluminum" EXACT [GOC:mah]
is_a: GO:0010044 ! response to aluminum ion
is_a: GO:0071248 ! cellular response to metal ion
created_by: midori
creation_date: 2009-12-10T03:52:20Z

[Term]
id: GO:0071276
name: cellular response to cadmium ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus." [GOC:mah]
subset: gosubset_prok
synonym: "cellular response to cadmium" EXACT [GOC:mah]
is_a: GO:0046686 ! response to cadmium ion
is_a: GO:0071248 ! cellular response to metal ion
created_by: midori
creation_date: 2009-12-10T03:54:49Z

[Term]
id: GO:0071277
name: cellular response to calcium ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]
synonym: "cellular response to Ca2+ ion" EXACT [GOC:mah]
is_a: GO:0051592 ! response to calcium ion
is_a: GO:0071248 ! cellular response to metal ion
created_by: midori
creation_date: 2009-12-10T03:55:01Z

[Term]
id: GO:0071278
name: cellular response to cesium ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cesium stimulus." [GOC:mah]
synonym: "cellular response to cesium" EXACT [GOC:mah]
is_a: GO:0010164 ! response to cesium ion
is_a: GO:0071248 ! cellular response to metal ion
created_by: midori
creation_date: 2009-12-10T03:55:44Z

[Term]
id: GO:0071279
name: cellular response to cobalt ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalt ion stimulus." [GOC:mah]
is_a: GO:0032025 ! response to cobalt ion
is_a: GO:0071248 ! cellular response to metal ion
created_by: midori
creation_date: 2009-12-10T03:55:55Z

[Term]
id: GO:0071280
name: cellular response to copper ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus." [GOC:mah]
subset: gosubset_prok
synonym: "cellular response to copper" EXACT [GOC:mah]
is_a: GO:0046688 ! response to copper ion
is_a: GO:0071248 ! cellular response to metal ion
created_by: midori
creation_date: 2009-12-10T03:57:03Z

[Term]
id: GO:0071281
name: cellular response to iron ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus." [GOC:mah]
synonym: "cellular response to iron" EXACT [GOC:mah]
is_a: GO:0010039 ! response to iron ion
is_a: GO:0071248 ! cellular response to metal ion
created_by: midori
creation_date: 2009-12-10T03:57:22Z

[Term]
id: GO:0071282
name: cellular response to iron(II) ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(II) ion stimulus." [GOC:mah]
synonym: "cellular response to iron(II)" EXACT [GOC:mah]
is_a: GO:0010040 ! response to iron(II) ion
is_a: GO:0071281 ! cellular response to iron ion
created_by: midori
creation_date: 2009-12-10T03:57:49Z

[Term]
id: GO:0071283
name: cellular response to iron(III) ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(III) ion stimulus." [GOC:mah]
synonym: "cellular response to iron(III)" EXACT [GOC:mah]
is_a: GO:0010041 ! response to iron(III) ion
is_a: GO:0071281 ! cellular response to iron ion
created_by: midori
creation_date: 2009-12-10T03:58:00Z

[Term]
id: GO:0071284
name: cellular response to lead ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus." [GOC:mah]
is_a: GO:0010288 ! response to lead ion
is_a: GO:0071248 ! cellular response to metal ion
created_by: midori
creation_date: 2009-12-10T04:00:41Z

[Term]
id: GO:0071285
name: cellular response to lithium ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus." [GOC:mah]
is_a: GO:0010226 ! response to lithium ion
is_a: GO:0071248 ! cellular response to metal ion
created_by: midori
creation_date: 2009-12-10T04:04:13Z

[Term]
id: GO:0071286
name: cellular response to magnesium ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus." [GOC:mah]
is_a: GO:0032026 ! response to magnesium ion
is_a: GO:0071248 ! cellular response to metal ion
created_by: midori
creation_date: 2009-12-10T04:05:50Z

[Term]
id: GO:0071287
name: cellular response to manganese ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a manganese ion stimulus." [GOC:mah]
synonym: "cellular response to manganese" EXACT [GOC:mah]
is_a: GO:0010042 ! response to manganese ion
is_a: GO:0071248 ! cellular response to metal ion
created_by: midori
creation_date: 2009-12-10T04:06:18Z

[Term]
id: GO:0071288
name: cellular response to mercury ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus." [GOC:mah]
subset: gosubset_prok
synonym: "cellular response to mercuric ion" EXACT [GOC:mah]
synonym: "cellular response to mercury" EXACT [GOC:mah]
is_a: GO:0046689 ! response to mercury ion
is_a: GO:0071248 ! cellular response to metal ion
created_by: midori
creation_date: 2009-12-10T04:06:37Z

[Term]
id: GO:0071289
name: cellular response to nickel ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nickel ion stimulus." [GOC:mah]
synonym: "cellular response to nickel" EXACT [GOC:mah]
is_a: GO:0010045 ! response to nickel cation
is_a: GO:0071248 ! cellular response to metal ion
created_by: midori
creation_date: 2009-12-10T04:07:31Z

[Term]
id: GO:0071290
name: cellular response to platinum ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platinum stimulus." [GOC:mah]
synonym: "cellular response to platinum" EXACT [GOC:mah]
is_a: GO:0070541 ! response to platinum ion
is_a: GO:0071248 ! cellular response to metal ion
created_by: midori
creation_date: 2009-12-10T04:08:06Z

[Term]
id: GO:0071291
name: cellular response to selenium ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from selenium ion." [GOC:mah]
is_a: GO:0010269 ! response to selenium ion
is_a: GO:0071248 ! cellular response to metal ion
created_by: midori
creation_date: 2009-12-10T04:15:52Z

[Term]
id: GO:0071292
name: cellular response to silver ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a silver ion stimulus." [GOC:mah]
is_a: GO:0010272 ! response to silver ion
is_a: GO:0071248 ! cellular response to metal ion
created_by: midori
creation_date: 2009-12-10T04:16:30Z

[Term]
id: GO:0071293
name: cellular response to tellurium ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tellurium ion stimulus." [GOC:mah]
subset: gosubset_prok
synonym: "cellular response to tellurium" EXACT [GOC:mah]
is_a: GO:0046690 ! response to tellurium ion
is_a: GO:0071248 ! cellular response to metal ion
created_by: midori
creation_date: 2009-12-10T04:16:52Z

[Term]
id: GO:0071294
name: cellular response to zinc ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus." [GOC:mah]
synonym: "cellular response to zinc" EXACT [GOC:mah]
is_a: GO:0010043 ! response to zinc ion
is_a: GO:0071248 ! cellular response to metal ion
created_by: midori
creation_date: 2009-12-10T04:17:10Z

[Term]
id: GO:0071295
name: cellular response to vitamin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin stimulus." [GOC:mah]
is_a: GO:0031670 ! cellular response to nutrient
is_a: GO:0033273 ! response to vitamin
created_by: midori
creation_date: 2009-12-10T04:27:24Z

[Term]
id: GO:0071296
name: cellular response to biotin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotin stimulus." [GOC:mah]
synonym: "cellular response to Bios IIB" EXACT [GOC:sl]
synonym: "cellular response to coenzyme R" EXACT [GOC:sl]
synonym: "cellular response to vitamin B7" EXACT [GOC:sl]
synonym: "cellular response to vitamin H" EXACT [GOC:sl]
is_a: GO:0070781 ! response to biotin
is_a: GO:0071229 ! cellular response to acid chemical
is_a: GO:0071295 ! cellular response to vitamin
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: midori
creation_date: 2009-12-10T04:28:22Z

[Term]
id: GO:0071297
name: cellular response to cobalamin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalamin (vitamin B12) stimulus." [GOC:mah]
synonym: "cellular response to vitamin B12" EXACT [GOC:mah]
is_a: GO:0033590 ! response to cobalamin
is_a: GO:0071295 ! cellular response to vitamin
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
created_by: midori
creation_date: 2009-12-10T04:28:45Z

[Term]
id: GO:0071298
name: cellular response to L-ascorbic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an L-ascorbic acid (vitamin C) stimulus." [GOC:mah]
synonym: "cellular response to ascorbic acid" BROAD [GOC:mah]
synonym: "cellular response to L-ascorbate" EXACT [GOC:mah]
synonym: "cellular response to vitamin C" EXACT [GOC:mah]
is_a: GO:0033591 ! response to L-ascorbic acid
is_a: GO:0071229 ! cellular response to acid chemical
is_a: GO:0071295 ! cellular response to vitamin
is_a: GO:0071326 ! cellular response to monosaccharide stimulus
created_by: midori
creation_date: 2009-12-10T04:29:19Z

[Term]
id: GO:0071299
name: cellular response to vitamin A
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin A stimulus." [GOC:mah]
synonym: "cellular response to retinol" NARROW [GOC:mah]
is_a: GO:0033189 ! response to vitamin A
is_a: GO:0071295 ! cellular response to vitamin
is_a: GO:0071396 ! cellular response to lipid
created_by: midori
creation_date: 2009-12-10T04:29:30Z

[Term]
id: GO:0071300
name: cellular response to retinoic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus." [GOC:mah]
synonym: "cellular response to vitamin A acid" EXACT [GOC:mah]
is_a: GO:0032526 ! response to retinoic acid
is_a: GO:0071229 ! cellular response to acid chemical
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: midori
creation_date: 2009-12-10T04:30:34Z

[Term]
id: GO:0071301
name: cellular response to vitamin B1
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B1 stimulus." [GOC:mah]
synonym: "cellular response to thiamin" EXACT [GOC:mah]
synonym: "cellular response to thiamine" EXACT [GOC:mah]
is_a: GO:0010266 ! response to vitamin B1
is_a: GO:0071295 ! cellular response to vitamin
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
created_by: midori
creation_date: 2009-12-10T04:32:09Z

[Term]
id: GO:0071302
name: cellular response to vitamin B2
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B2 stimulus." [GOC:mah]
synonym: "cellular response to riboflavin" EXACT [GOC:mah]
is_a: GO:0033274 ! response to vitamin B2
is_a: GO:0071295 ! cellular response to vitamin
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
created_by: midori
creation_date: 2009-12-10T04:34:52Z

[Term]
id: GO:0071303
name: cellular response to vitamin B3
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B3 stimulus." [GOC:mah]
synonym: "cellular response to niacin" NARROW [GOC:mah]
synonym: "cellular response to nicotinamide" NARROW [GOC:mah]
is_a: GO:0033552 ! response to vitamin B3
is_a: GO:0071295 ! cellular response to vitamin
created_by: midori
creation_date: 2009-12-10T04:35:04Z

[Term]
id: GO:0071304
name: cellular response to vitamin B6
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B6 stimulus. Vitamin B6 encompasses pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate." [GOC:mah]
is_a: GO:0034516 ! response to vitamin B6
is_a: GO:0071295 ! cellular response to vitamin
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
created_by: midori
creation_date: 2009-12-10T04:35:23Z

[Term]
id: GO:0071305
name: cellular response to vitamin D
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus." [GOC:mah]
synonym: "cellular response to calciferol" EXACT [GOC:mah]
synonym: "cellular response to cholecalciferol" NARROW [GOC:mah]
synonym: "cellular response to ergocalciferol" NARROW [GOC:mah]
is_a: GO:0033280 ! response to vitamin D
is_a: GO:0071295 ! cellular response to vitamin
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0097306 ! cellular response to alcohol
created_by: midori
creation_date: 2009-12-10T04:35:37Z

[Term]
id: GO:0071306
name: cellular response to vitamin E
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin E stimulus." [GOC:mah]
synonym: "cellular response to DL-alpha-tocopherol acetate" NARROW [GOC:mah]
synonym: "cellular response to DL-alpha-tocopheryl acetate" NARROW [GOC:mah]
synonym: "cellular response to O-Acetyl-alpha-tocopherol" NARROW [GOC:mah]
is_a: GO:0033197 ! response to vitamin E
is_a: GO:0071295 ! cellular response to vitamin
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: midori
creation_date: 2009-12-10T04:35:58Z

[Term]
id: GO:0071307
name: cellular response to vitamin K
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin K stimulus." [GOC:mah]
is_a: GO:0032571 ! response to vitamin K
is_a: GO:0071295 ! cellular response to vitamin
is_a: GO:1901655 ! cellular response to ketone
created_by: midori
creation_date: 2009-12-10T04:36:09Z

[Term]
id: GO:0071308
name: cellular response to menaquinone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a menaquinone (vitamin K2) stimulus." [GOC:mah]
synonym: "cellular response to menatetrenone" EXACT [GOC:mah]
synonym: "cellular response to vitamin K2" EXACT [GOC:mah]
is_a: GO:0032572 ! response to menaquinone
is_a: GO:0071310 ! cellular response to organic substance
is_a: GO:1901655 ! cellular response to ketone
created_by: midori
creation_date: 2009-12-10T04:37:08Z

[Term]
id: GO:0071309
name: cellular response to phylloquinone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phylloquinone (vitamin K1) stimulus." [GOC:mah]
synonym: "cellular response to vitamin K1" EXACT [GOC:mah]
is_a: GO:0032573 ! response to phylloquinone
is_a: GO:1901655 ! cellular response to ketone
created_by: midori
creation_date: 2009-12-10T04:37:18Z

[Term]
id: GO:0071310
name: cellular response to organic substance
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus." [GOC:mah]
subset: gosubset_prok
is_a: GO:0010033 ! response to organic substance
is_a: GO:0070887 ! cellular response to chemical stimulus
created_by: midori
creation_date: 2009-12-10T04:46:04Z

[Term]
id: GO:0071311
name: cellular response to acetate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetate stimulus." [GOC:mah]
subset: gosubset_prok
is_a: GO:0010034 ! response to acetate
is_a: GO:0071229 ! cellular response to acid chemical
is_a: GO:0071310 ! cellular response to organic substance
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: midori
creation_date: 2009-12-10T04:48:16Z

[Term]
id: GO:0071312
name: cellular response to alkaloid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active." [GOC:mah]
is_a: GO:0043279 ! response to alkaloid
is_a: GO:0071417 ! cellular response to organonitrogen compound
created_by: midori
creation_date: 2009-12-10T04:50:58Z

[Term]
id: GO:0071313
name: cellular response to caffeine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them." [GOC:mah]
is_a: GO:0031000 ! response to caffeine
is_a: GO:0071312 ! cellular response to alkaloid
is_a: GO:0071415 ! cellular response to purine-containing compound
created_by: midori
creation_date: 2009-12-10T04:52:51Z

[Term]
id: GO:0071314
name: cellular response to cocaine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant." [GOC:mah]
is_a: GO:0042220 ! response to cocaine
is_a: GO:0071242 ! cellular response to ammonium ion
is_a: GO:0071312 ! cellular response to alkaloid
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: midori
creation_date: 2009-12-10T04:53:20Z

[Term]
id: GO:0071315
name: cellular response to morphine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure." [GOC:mah]
is_a: GO:0043278 ! response to morphine
is_a: GO:0071242 ! cellular response to ammonium ion
is_a: GO:0071317 ! cellular response to isoquinoline alkaloid
created_by: midori
creation_date: 2009-12-10T04:53:46Z

[Term]
id: GO:0071316
name: cellular response to nicotine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus." [GOC:mah]
is_a: GO:0035094 ! response to nicotine
is_a: GO:0071312 ! cellular response to alkaloid
is_a: GO:0071407 ! cellular response to organic cyclic compound
created_by: midori
creation_date: 2009-12-10T05:05:05Z

[Term]
id: GO:0071317
name: cellular response to isoquinoline alkaloid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isoquinoline alkaloid stimulus. An isoquinoline alkaloid is any member of a group of compounds with the heterocyclic ring structure of benzo(c)pyridine which is a structure characteristic of the group of opium alkaloids." [GOC:mah]
is_a: GO:0014072 ! response to isoquinoline alkaloid
is_a: GO:0071312 ! cellular response to alkaloid
is_a: GO:0071407 ! cellular response to organic cyclic compound
created_by: midori
creation_date: 2009-12-10T05:06:08Z

[Term]
id: GO:0071318
name: cellular response to ATP
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus." [GOC:mah]
synonym: "cellular response to adenosine 5'-triphosphate" EXACT [GOC:mah]
synonym: "cellular response to adenosine triphosphate" EXACT [GOC:mah]
is_a: GO:0033198 ! response to ATP
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: midori
creation_date: 2009-12-10T05:09:47Z

[Term]
id: GO:0071319
name: cellular response to benzoic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benzoic acid stimulus." [GOC:mah]
is_a: GO:0071229 ! cellular response to acid chemical
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0080021 ! response to benzoic acid
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: midori
creation_date: 2009-12-10T05:10:20Z

[Term]
id: GO:0071320
name: cellular response to cAMP
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus." [GOC:mah]
synonym: "cellular response to 3',5' cAMP" EXACT [GOC:mah]
synonym: "cellular response to 3',5'-cAMP" EXACT [GOC:mah]
synonym: "cellular response to adenosine 3',5'-cyclophosphate" EXACT [GOC:mah]
synonym: "cellular response to cyclic AMP" EXACT [GOC:mah]
is_a: GO:0051591 ! response to cAMP
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: midori
creation_date: 2009-12-10T05:12:15Z

[Term]
id: GO:0071321
name: cellular response to cGMP
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cGMP (cyclic GMP, guanosine 3',5'-cyclophosphate) stimulus." [GOC:mah]
synonym: "cellular response to 3',5' cGMP" EXACT [GOC:mah]
synonym: "cellular response to 3',5'-cGMP" EXACT [GOC:mah]
synonym: "cellular response to cyclic GMP" EXACT [GOC:mah]
synonym: "cellular response to guanosine 3',5'-cyclophosphate" EXACT [GOC:mah]
is_a: GO:0070305 ! response to cGMP
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: midori
creation_date: 2009-12-10T05:12:58Z

[Term]
id: GO:0071322
name: cellular response to carbohydrate stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus." [GOC:mah]
is_a: GO:0009743 ! response to carbohydrate
is_a: GO:0071310 ! cellular response to organic substance
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: midori
creation_date: 2009-12-10T05:13:33Z

[Term]
id: GO:0071323
name: cellular response to chitin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chitin stimulus." [GOC:mah]
is_a: GO:0010200 ! response to chitin
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: midori
creation_date: 2009-12-10T05:25:54Z

[Term]
id: GO:0071324
name: cellular response to disaccharide stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disaccharide stimulus." [GOC:mah]
is_a: GO:0034285 ! response to disaccharide
is_a: GO:0071322 ! cellular response to carbohydrate stimulus
created_by: midori
creation_date: 2009-12-10T05:26:14Z

[Term]
id: GO:0071325
name: cellular response to mannitol stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus." [GOC:mah]
is_a: GO:0010555 ! response to mannitol
is_a: GO:0071322 ! cellular response to carbohydrate stimulus
created_by: midori
creation_date: 2009-12-10T05:27:00Z

[Term]
id: GO:0071326
name: cellular response to monosaccharide stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosaccharide stimulus." [GOC:mah]
is_a: GO:0034284 ! response to monosaccharide
is_a: GO:0071322 ! cellular response to carbohydrate stimulus
created_by: midori
creation_date: 2009-12-10T05:27:18Z

[Term]
id: GO:0071327
name: cellular response to trehalose stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trehalose stimulus." [GOC:mah]
is_a: GO:0010353 ! response to trehalose
is_a: GO:0071324 ! cellular response to disaccharide stimulus
created_by: midori
creation_date: 2009-12-10T05:27:54Z

[Term]
id: GO:0071328
name: cellular response to maltose stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a maltose stimulus." [GOC:mah]
is_a: GO:0034286 ! response to maltose
is_a: GO:0071324 ! cellular response to disaccharide stimulus
created_by: midori
creation_date: 2009-12-10T05:30:45Z

[Term]
id: GO:0071329
name: cellular response to sucrose stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus." [GOC:mah]
is_a: GO:0009744 ! response to sucrose
is_a: GO:0071324 ! cellular response to disaccharide stimulus
created_by: midori
creation_date: 2009-12-10T05:31:22Z

[Term]
id: GO:0071330
name: cellular response to trehalose-6-phosphate stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trehalose-6-phosphate stimulus." [GOC:mah]
is_a: GO:0071324 ! cellular response to disaccharide stimulus
is_a: GO:0080094 ! response to trehalose-6-phosphate
created_by: midori
creation_date: 2009-12-10T05:32:52Z

[Term]
id: GO:0071331
name: cellular response to hexose stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus." [GOC:mah]
is_a: GO:0009746 ! response to hexose
is_a: GO:0071326 ! cellular response to monosaccharide stimulus
created_by: midori
creation_date: 2009-12-10T05:37:00Z

[Term]
id: GO:0071332
name: cellular response to fructose stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fructose stimulus." [GOC:mah]
is_a: GO:0009750 ! response to fructose
is_a: GO:0071331 ! cellular response to hexose stimulus
created_by: midori
creation_date: 2009-12-10T05:37:39Z

[Term]
id: GO:0071333
name: cellular response to glucose stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus." [GOC:mah]
is_a: GO:0001678 ! cellular glucose homeostasis
is_a: GO:0009749 ! response to glucose
is_a: GO:0071331 ! cellular response to hexose stimulus
created_by: midori
creation_date: 2009-12-10T05:38:03Z

[Term]
id: GO:0071334
name: cellular response to rhamnose stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rhamnose stimulus." [GOC:mah]
synonym: "cellular response to L-rhamnose stimulus" NARROW [GOC:mah]
is_a: GO:0032149 ! response to rhamnose
is_a: GO:0071331 ! cellular response to hexose stimulus
created_by: midori
creation_date: 2009-12-10T05:38:38Z

[Term]
id: GO:0071335
name: hair follicle cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of hair follicle cells, resulting in the expansion of a cell population." [GOC:rph, PMID:16086254]
is_a: GO:0008283 ! cell proliferation
created_by: midori
creation_date: 2009-12-11T10:49:53Z

[Term]
id: GO:0071336
name: regulation of hair follicle cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hair follicle cell proliferation." [GOC:mah]
is_a: GO:0042127 ! regulation of cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071335 ! hair follicle cell proliferation
relationship: regulates GO:0071335 ! hair follicle cell proliferation
created_by: midori
creation_date: 2009-12-11T10:53:40Z

[Term]
id: GO:0071337
name: negative regulation of hair follicle cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of hair follicle cell proliferation." [GOC:mah]
synonym: "down regulation of hair follicle cell proliferation" EXACT [GOC:mah]
synonym: "down-regulation of hair follicle cell proliferation" EXACT [GOC:mah]
synonym: "downregulation of hair follicle cell proliferation" EXACT [GOC:mah]
synonym: "inhibition of hair follicle cell proliferation" NARROW [GOC:mah]
is_a: GO:0008285 ! negative regulation of cell proliferation
is_a: GO:0071336 ! regulation of hair follicle cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071335 ! hair follicle cell proliferation
relationship: negatively_regulates GO:0071335 ! hair follicle cell proliferation
created_by: midori
creation_date: 2009-12-11T10:59:20Z

[Term]
id: GO:0071338
name: positive regulation of hair follicle cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of hair follicle cell proliferation." [GOC:mah]
synonym: "activation of hair follicle cell proliferation" NARROW [GOC:mah]
synonym: "stimulation of hair follicle cell proliferation" NARROW [GOC:mah]
synonym: "up regulation of hair follicle cell proliferation" EXACT [GOC:mah]
synonym: "up-regulation of hair follicle cell proliferation" EXACT [GOC:mah]
synonym: "upregulation of hair follicle cell proliferation" EXACT [GOC:mah]
is_a: GO:0008284 ! positive regulation of cell proliferation
is_a: GO:0071336 ! regulation of hair follicle cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071335 ! hair follicle cell proliferation
relationship: positively_regulates GO:0071335 ! hair follicle cell proliferation
created_by: midori
creation_date: 2009-12-11T11:00:57Z

[Term]
id: GO:0071339
name: MLL1 complex
namespace: cellular_component
def: "A protein complex that can methylate lysine-4 of histone H3. MLL1/MLL is the catalytic methyltransferase subunit, and the complex also contains the core components ASH2L, HCFC1/HCF1 WDR5 and RBBP5." [GOC:sp, PMID:15960975]
is_a: GO:0044665 ! MLL1/2 complex
created_by: midori
creation_date: 2009-12-11T11:11:36Z

[Term]
id: GO:0071340
name: skeletal muscle acetylcholine-gated channel clustering
namespace: biological_process
def: "The accumulation of acetylcholine-gated cation channels in a narrow, central region of muscle fibers, in apposition to nerve terminals." [GOC:bf, GOC:dsf, PMID:19285469]
synonym: "skeletal muscle AChR clustering" EXACT [GOC:mah]
synonym: "skeletal muscle nicotinic acetylcholine receptor clustering" EXACT [GOC:bf]
is_a: GO:0043113 ! receptor clustering
relationship: part_of GO:0001941 ! postsynaptic membrane organization
relationship: part_of GO:0007528 ! neuromuscular junction development
created_by: midori
creation_date: 2009-12-11T11:13:55Z

[Term]
id: GO:0071341
name: medial cortical node
namespace: cellular_component
def: "A component of the cell division site that contains the mid1, cdr2, wee1, klp8, and blt1 proteins, and is involved in contractile ring localization. Medial cortical node complexes appear as cortical dots in the middle of the cell during interphase, and function to recruit other ring components in early mitosis." [GOC:mah, GOC:vw, PMID:19474789, PMID:19959363]
synonym: "mid1p medial cortical dot" EXACT [GOC:vw]
synonym: "midsome" EXACT [GOC:vw, PMID:19959363]
is_a: GO:0032155 ! cell division site part
is_a: GO:0044448 ! cell cortex part
relationship: part_of GO:0031097 ! medial cortex
created_by: midori
creation_date: 2009-12-11T11:40:36Z

[Term]
id: GO:0071342
name: regulation of establishment of actomyosin contractile ring localization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the process in which a contractile ring is assembled in a specific location that contributes to cytokinesis during cell cycle." [GOC:dph, GOC:mah, GOC:tb]
synonym: "regulation of establishment of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:mah]
synonym: "regulation of establishment of contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:mah, GOC:vw]
synonym: "regulation of establishment of contractile ring localization involved in cytokinesis during cell cycle" RELATED [GOC:dph, GOC:tb]
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:1901648 ! regulation of actomyosin contractile ring localization
is_a: GO:2000073 ! regulation of cytokinesis, site selection
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032188 ! establishment of actomyosin contractile ring localization
relationship: regulates GO:0032188 ! establishment of actomyosin contractile ring localization
created_by: midori
creation_date: 2009-12-11T01:22:11Z

[Term]
id: GO:0071343
name: obsolete negative regulation of establishment of actomyosin contractile ring localization
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the process in which a contractile ring is assembled in a specific location." [GOC:mah]
comment: This term was made obsolete because it does not describe a wild-type or normal process.
synonym: "negative regulation of establishment of actomyosin contractile ring localization" EXACT []
synonym: "negative regulation of establishment of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:mah]
synonym: "negative regulation of establishment of contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:mah, GOC:vw]
synonym: "negative regulation of establishment of contractile ring localization involved in cytokinesis during cell cycle" RELATED [GOC:dph, GOC:tb]
is_obsolete: true
created_by: midori
creation_date: 2009-12-11T01:33:14Z

[Term]
id: GO:0071344
name: diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving diphosphate, the anion or salt of diphosphoric acid." [CHEBI:35782, GOC:pde]
subset: gosubset_prok
synonym: "pyrophosphate metabolism" EXACT [GOC:mah]
xref: Reactome:REACT_100411 "Pyrophosphate hydrolysis, Sus scrofa"
xref: Reactome:REACT_110038 "Pyrophosphate hydrolysis, Taeniopygia guttata"
xref: Reactome:REACT_112316 "Pyrophosphate hydrolysis, Oryza sativa"
xref: Reactome:REACT_113577 "Pyrophosphate hydrolysis, Plasmodium falciparum"
xref: Reactome:REACT_114742 "Pyrophosphate hydrolysis, Arabidopsis thaliana"
xref: Reactome:REACT_115179 "Pyrophosphate hydrolysis, Mycobacterium tuberculosis"
xref: Reactome:REACT_21259 "Pyrophosphate hydrolysis, Homo sapiens"
xref: Reactome:REACT_28484 "Pyrophosphate hydrolysis, Danio rerio"
xref: Reactome:REACT_31182 "Pyrophosphate hydrolysis, Xenopus tropicalis"
xref: Reactome:REACT_31593 "Pyrophosphate hydrolysis, Saccharomyces cerevisiae"
xref: Reactome:REACT_34239 "Pyrophosphate hydrolysis, Schizosaccharomyces pombe"
xref: Reactome:REACT_78079 "Pyrophosphate hydrolysis, Bos taurus"
xref: Reactome:REACT_81374 "Pyrophosphate hydrolysis, Caenorhabditis elegans"
xref: Reactome:REACT_82005 "Pyrophosphate hydrolysis, Rattus norvegicus"
xref: Reactome:REACT_83290 "Pyrophosphate hydrolysis, Gallus gallus"
xref: Reactome:REACT_85626 "Pyrophosphate hydrolysis, Canis familiaris"
xref: Reactome:REACT_87824 "Pyrophosphate hydrolysis, Dictyostelium discoideum"
xref: Reactome:REACT_94689 "Pyrophosphate hydrolysis, Drosophila melanogaster"
xref: Reactome:REACT_95630 "Pyrophosphate hydrolysis, Mus musculus"
is_a: GO:0006793 ! phosphorus metabolic process
is_a: GO:0043436 ! oxoacid metabolic process
created_by: midori
creation_date: 2009-12-11T01:43:41Z

[Term]
id: GO:0071345
name: cellular response to cytokine stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:mah]
is_a: GO:0034097 ! response to cytokine
is_a: GO:0071310 ! cellular response to organic substance
created_by: midori
creation_date: 2009-12-11T02:41:12Z

[Term]
id: GO:0071346
name: cellular response to interferon-gamma
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far." [GOC:mah, PR:000000017]
synonym: "cellular response to gamma-interferon" RELATED [GOC:mah]
synonym: "cellular response to immune interferon" EXACT [GOC:mah]
synonym: "cellular response to type II IFN" BROAD [GOC:mah]
synonym: "cellular response to type II interferon" BROAD [GOC:mah]
is_a: GO:0034341 ! response to interferon-gamma
is_a: GO:0071345 ! cellular response to cytokine stimulus
created_by: midori
creation_date: 2009-12-11T02:48:00Z

[Term]
id: GO:0071347
name: cellular response to interleukin-1
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus." [GOC:mah]
synonym: "cellular response to IL-1" EXACT [GOC:mah]
is_a: GO:0070555 ! response to interleukin-1
is_a: GO:0071345 ! cellular response to cytokine stimulus
created_by: midori
creation_date: 2009-12-11T02:49:17Z

[Term]
id: GO:0071348
name: cellular response to interleukin-11
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-11 stimulus." [GOC:mah]
synonym: "cellular response to IL-11" EXACT [GOC:mah]
is_a: GO:0071105 ! response to interleukin-11
is_a: GO:0071345 ! cellular response to cytokine stimulus
created_by: midori
creation_date: 2009-12-11T02:49:29Z

[Term]
id: GO:0071349
name: cellular response to interleukin-12
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-12 stimulus." [GOC:mah]
synonym: "cellular response to IL-12" EXACT [GOC:mah]
is_a: GO:0070671 ! response to interleukin-12
is_a: GO:0071345 ! cellular response to cytokine stimulus
created_by: midori
creation_date: 2009-12-11T02:49:40Z

[Term]
id: GO:0071350
name: cellular response to interleukin-15
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-15 stimulus." [GOC:mah]
synonym: "cellular response to IL-15" EXACT [GOC:mah]
is_a: GO:0070672 ! response to interleukin-15
is_a: GO:0071345 ! cellular response to cytokine stimulus
created_by: midori
creation_date: 2009-12-11T02:49:51Z

[Term]
id: GO:0071351
name: cellular response to interleukin-18
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-18 stimulus." [GOC:mah]
synonym: "cellular response to IL-18" EXACT [GOC:mah]
is_a: GO:0070673 ! response to interleukin-18
is_a: GO:0071345 ! cellular response to cytokine stimulus
created_by: midori
creation_date: 2009-12-11T02:50:03Z

[Term]
id: GO:0071352
name: cellular response to interleukin-2
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-2 stimulus." [GOC:mah]
synonym: "cellular response to IL-2" EXACT [GOC:mah]
is_a: GO:0070669 ! response to interleukin-2
is_a: GO:0071345 ! cellular response to cytokine stimulus
created_by: midori
creation_date: 2009-12-11T02:50:48Z

[Term]
id: GO:0071353
name: cellular response to interleukin-4
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus." [GOC:mah]
synonym: "cellular response to IL-4" EXACT [GOC:mah]
is_a: GO:0070670 ! response to interleukin-4
is_a: GO:0071345 ! cellular response to cytokine stimulus
created_by: midori
creation_date: 2009-12-11T02:51:00Z

[Term]
id: GO:0071354
name: cellular response to interleukin-6
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus." [GOC:mah]
synonym: "cellular response to IL-6" EXACT [GOC:mah]
is_a: GO:0070741 ! response to interleukin-6
is_a: GO:0071345 ! cellular response to cytokine stimulus
created_by: midori
creation_date: 2009-12-11T02:51:14Z

[Term]
id: GO:0071355
name: cellular response to interleukin-9
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-9 stimulus." [GOC:mah]
synonym: "cellular response to IL-9" EXACT [GOC:mah]
is_a: GO:0071104 ! response to interleukin-9
is_a: GO:0071345 ! cellular response to cytokine stimulus
created_by: midori
creation_date: 2009-12-11T02:51:26Z

[Term]
id: GO:0071356
name: cellular response to tumor necrosis factor
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus." [GOC:mah]
synonym: "cellular response to TNF" EXACT [GOC:mah]
is_a: GO:0034612 ! response to tumor necrosis factor
is_a: GO:0071345 ! cellular response to cytokine stimulus
created_by: midori
creation_date: 2009-12-11T02:51:37Z

[Term]
id: GO:0071357
name: cellular response to type I interferon
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:mah, PR:000025848]
synonym: "cellular response to type I IFN" EXACT [GOC:mah]
is_a: GO:0034340 ! response to type I interferon
is_a: GO:0071345 ! cellular response to cytokine stimulus
created_by: midori
creation_date: 2009-12-11T02:51:47Z

[Term]
id: GO:0071358
name: cellular response to type III interferon
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type III interferon stimulus. Interferon lambda is the only member of the type III interferon found so far." [GOC:mah]
synonym: "cellular response to interferon-lambda" NARROW [GOC:mah]
synonym: "cellular response to type III IFN" EXACT [GOC:mah]
is_a: GO:0034342 ! response to type III interferon
is_a: GO:0071345 ! cellular response to cytokine stimulus
created_by: midori
creation_date: 2009-12-11T02:52:00Z

[Term]
id: GO:0071359
name: cellular response to dsRNA
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded RNA stimulus." [GOC:mah]
synonym: "cellular response to double-stranded RNA" EXACT [GOC:mah]
is_a: GO:0043331 ! response to dsRNA
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901699 ! cellular response to nitrogen compound
created_by: midori
creation_date: 2009-12-11T03:00:32Z

[Term]
id: GO:0071360
name: cellular response to exogenous dsRNA
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus." [GOC:mah]
synonym: "cellular response to exogenous double-stranded RNA" EXACT [GOC:mah]
synonym: "cellular response to viral dsRNA" NARROW [GOC:mah]
is_a: GO:0043330 ! response to exogenous dsRNA
is_a: GO:0071359 ! cellular response to dsRNA
created_by: midori
creation_date: 2009-12-11T03:02:00Z

[Term]
id: GO:0071361
name: cellular response to ethanol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus." [GOC:mah]
is_a: GO:0045471 ! response to ethanol
is_a: GO:0097306 ! cellular response to alcohol
created_by: midori
creation_date: 2009-12-11T03:02:59Z

[Term]
id: GO:0071362
name: cellular response to ether
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ether stimulus." [GOC:mah]
is_a: GO:0045472 ! response to ether
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: midori
creation_date: 2009-12-11T03:03:22Z

[Term]
id: GO:0071363
name: cellular response to growth factor stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:mah]
is_a: GO:0070848 ! response to growth factor
is_a: GO:0071310 ! cellular response to organic substance
created_by: midori
creation_date: 2009-12-11T03:05:07Z

[Term]
id: GO:0071364
name: cellular response to epidermal growth factor stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus." [GOC:mah]
synonym: "cellular response to EGF stimulus" EXACT [GOC:mah]
is_a: GO:0070849 ! response to epidermal growth factor
is_a: GO:0071363 ! cellular response to growth factor stimulus
is_a: GO:0071495 ! cellular response to endogenous stimulus
created_by: midori
creation_date: 2009-12-11T03:05:34Z

[Term]
id: GO:0071365
name: cellular response to auxin stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auxin stimulus." [GOC:mah]
is_a: GO:0009733 ! response to auxin
is_a: GO:0032870 ! cellular response to hormone stimulus
created_by: midori
creation_date: 2009-12-11T03:10:22Z

[Term]
id: GO:0071366
name: cellular response to indolebutyric acid stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indolebutyric acid stimulus." [GOC:mah]
synonym: "cellular response to IBA stimulus" EXACT [GOC:mah]
synonym: "cellular response to indole-3-butyric acid stimulus" NARROW [GOC:mah]
is_a: GO:0071229 ! cellular response to acid chemical
is_a: GO:0071365 ! cellular response to auxin stimulus
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:0080026 ! response to indolebutyric acid
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: midori
creation_date: 2009-12-11T03:12:14Z

[Term]
id: GO:0071367
name: cellular response to brassinosteroid stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brassinosteroid stimulus." [GOC:mah]
is_a: GO:0009741 ! response to brassinosteroid
is_a: GO:0032870 ! cellular response to hormone stimulus
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0097306 ! cellular response to alcohol
created_by: midori
creation_date: 2009-12-11T03:13:33Z

[Term]
id: GO:0071368
name: cellular response to cytokinin stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokinin stimulus." [GOC:mah]
is_a: GO:0009735 ! response to cytokinin
is_a: GO:0032870 ! cellular response to hormone stimulus
created_by: midori
creation_date: 2009-12-11T03:13:47Z

[Term]
id: GO:0071369
name: cellular response to ethylene stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethylene (ethene) stimulus." [GOC:mah]
synonym: "cellular response to ethene stimulus" EXACT [GOC:mah]
is_a: GO:0009723 ! response to ethylene
is_a: GO:0032870 ! cellular response to hormone stimulus
created_by: midori
creation_date: 2009-12-11T03:13:57Z

[Term]
id: GO:0071370
name: cellular response to gibberellin stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gibberellin stimulus." [GOC:mah]
synonym: "cellular response to gibberellic acid stimulus" NARROW [GOC:mah]
is_a: GO:0009739 ! response to gibberellin
is_a: GO:0032870 ! cellular response to hormone stimulus
is_a: GO:0071229 ! cellular response to acid chemical
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: midori
creation_date: 2009-12-11T03:14:21Z

[Term]
id: GO:0071371
name: cellular response to gonadotropin stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin stimulus." [GOC:mah]
synonym: "cellular response to gonadotrophin stimulus" EXACT [GOC:dph]
is_a: GO:0032870 ! cellular response to hormone stimulus
is_a: GO:0034698 ! response to gonadotropin
created_by: midori
creation_date: 2009-12-11T03:14:35Z

[Term]
id: GO:0071372
name: cellular response to follicle-stimulating hormone stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a follicle-stimulating hormone stimulus." [GOC:mah]
synonym: "cellular response to follicle stimulating hormone stimulus" EXACT []
synonym: "cellular response to FSH stimulus" EXACT []
is_a: GO:0032354 ! response to follicle-stimulating hormone
is_a: GO:0071371 ! cellular response to gonadotropin stimulus
created_by: midori
creation_date: 2009-12-11T03:15:56Z

[Term]
id: GO:0071373
name: cellular response to luteinizing hormone stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a luteinizing hormone stimulus." [GOC:mah]
is_a: GO:0034699 ! response to luteinizing hormone
is_a: GO:0071371 ! cellular response to gonadotropin stimulus
created_by: midori
creation_date: 2009-12-11T03:16:02Z

[Term]
id: GO:0071374
name: cellular response to parathyroid hormone stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a parathyroid hormone stimulus." [GOC:mah]
is_a: GO:0032870 ! cellular response to hormone stimulus
is_a: GO:0071107 ! response to parathyroid hormone
created_by: midori
creation_date: 2009-12-11T03:19:29Z

[Term]
id: GO:0071375
name: cellular response to peptide hormone stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [GOC:mah]
synonym: "cellular response to polypeptide hormone stimulus" EXACT [GOC:mah]
is_a: GO:0032870 ! cellular response to hormone stimulus
is_a: GO:0043434 ! response to peptide hormone
is_a: GO:1901653 ! cellular response to peptide
created_by: midori
creation_date: 2009-12-11T03:24:18Z

[Term]
id: GO:0071376
name: cellular response to corticotropin-releasing hormone stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticotropin-releasing hormone stimulus. Corticotropin-releasing hormone is a peptide hormone involved in the stress response." [GOC:mah]
synonym: "cellular response to corticoliberin stimulus" EXACT [GOC:mah]
synonym: "cellular response to corticotropin-releasing factor stimulus" EXACT [GOC:mah]
synonym: "cellular response to CRF stimulus" EXACT [GOC:mah]
synonym: "cellular response to CRH stimulus" EXACT [GOC:mah]
is_a: GO:0043435 ! response to corticotropin-releasing hormone
is_a: GO:0071375 ! cellular response to peptide hormone stimulus
created_by: midori
creation_date: 2009-12-11T03:24:56Z

[Term]
id: GO:0071377
name: cellular response to glucagon stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus." [GOC:mah]
xref: Reactome:REACT_102072 "Glucagon signaling in metabolic regulation, Gallus gallus"
xref: Reactome:REACT_102447 "Glucagon signaling in metabolic regulation, Xenopus tropicalis"
xref: Reactome:REACT_109438 "Glucagon signaling in metabolic regulation, Bos taurus"
xref: Reactome:REACT_110587 "Glucagon signaling in metabolic regulation, Dictyostelium discoideum"
xref: Reactome:REACT_113140 "Glucagon signaling in metabolic regulation, Plasmodium falciparum"
xref: Reactome:REACT_1665 "Glucagon signaling in metabolic regulation, Homo sapiens"
xref: Reactome:REACT_31751 "Glucagon signaling in metabolic regulation, Canis familiaris"
xref: Reactome:REACT_32266 "Glucagon signaling in metabolic regulation, Mus musculus"
xref: Reactome:REACT_33650 "Glucagon signaling in metabolic regulation, Schizosaccharomyces pombe"
xref: Reactome:REACT_83177 "Glucagon signaling in metabolic regulation, Caenorhabditis elegans"
xref: Reactome:REACT_83307 "Glucagon signaling in metabolic regulation, Danio rerio"
xref: Reactome:REACT_86328 "Glucagon signaling in metabolic regulation, Rattus norvegicus"
xref: Reactome:REACT_86735 "Glucagon signaling in metabolic regulation, Taeniopygia guttata"
xref: Reactome:REACT_97451 "Glucagon signaling in metabolic regulation, Sus scrofa"
xref: Reactome:REACT_97918 "Glucagon signaling in metabolic regulation, Drosophila melanogaster"
xref: Reactome:REACT_99518 "Glucagon signaling in metabolic regulation, Saccharomyces cerevisiae"
is_a: GO:0033762 ! response to glucagon
is_a: GO:0071375 ! cellular response to peptide hormone stimulus
created_by: midori
creation_date: 2009-12-11T03:25:07Z

[Term]
id: GO:0071378
name: cellular response to growth hormone stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone stimulus. Growth hormone is a peptide hormone that binds to the growth hormone receptor and stimulates growth." [GOC:mah]
is_a: GO:0060416 ! response to growth hormone
is_a: GO:0071375 ! cellular response to peptide hormone stimulus
created_by: midori
creation_date: 2009-12-11T03:25:17Z

[Term]
id: GO:0071379
name: cellular response to prostaglandin stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin stimulus." [GOC:mah]
is_a: GO:0032870 ! cellular response to hormone stimulus
is_a: GO:0034694 ! response to prostaglandin
is_a: GO:0071398 ! cellular response to fatty acid
created_by: midori
creation_date: 2009-12-11T03:33:52Z

[Term]
id: GO:0071380
name: cellular response to prostaglandin E stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus." [GOC:mah]
is_a: GO:0034695 ! response to prostaglandin E
is_a: GO:0071379 ! cellular response to prostaglandin stimulus
is_a: GO:1901655 ! cellular response to ketone
created_by: midori
creation_date: 2009-12-11T03:34:43Z

[Term]
id: GO:0071381
name: cellular response to prostaglandin F stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin F stimulus." [GOC:mah]
is_a: GO:0034696 ! response to prostaglandin F
is_a: GO:0071379 ! cellular response to prostaglandin stimulus
created_by: midori
creation_date: 2009-12-11T03:34:57Z

[Term]
id: GO:0071382
name: cellular response to prostaglandin I stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin I stimulus." [GOC:mah]
is_a: GO:0034697 ! response to prostaglandin I
is_a: GO:0071379 ! cellular response to prostaglandin stimulus
created_by: midori
creation_date: 2009-12-11T03:45:10Z

[Term]
id: GO:0071383
name: cellular response to steroid hormone stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus." [GOC:mah]
is_a: GO:0032870 ! cellular response to hormone stimulus
is_a: GO:0048545 ! response to steroid hormone
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:0071407 ! cellular response to organic cyclic compound
created_by: midori
creation_date: 2009-12-11T03:49:02Z

[Term]
id: GO:0071384
name: cellular response to corticosteroid stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosteroid hormone stimulus. A corticosteroid is a steroid hormone that is produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. They include glucocorticoids and mineralocorticoids." [GOC:mah]
is_a: GO:0031960 ! response to corticosteroid
is_a: GO:0071383 ! cellular response to steroid hormone stimulus
created_by: midori
creation_date: 2009-12-11T03:52:07Z

[Term]
id: GO:0071385
name: cellular response to glucocorticoid stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects." [GOC:mah]
is_a: GO:0051384 ! response to glucocorticoid
is_a: GO:0071384 ! cellular response to corticosteroid stimulus
created_by: midori
creation_date: 2009-12-11T03:53:56Z

[Term]
id: GO:0071386
name: cellular response to corticosterone stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosterone stimulus. Corticosterone is a 21 carbon steroid hormone of the corticosteroid type, produced in the cortex of the adrenal glands. In many species, corticosterone is the principal glucocorticoid, involved in regulation of fuel metabolism, immune reactions, and stress responses." [GOC:mah]
is_a: GO:0051412 ! response to corticosterone
is_a: GO:0071385 ! cellular response to glucocorticoid stimulus
is_a: GO:0071389 ! cellular response to mineralocorticoid stimulus
is_a: GO:0097306 ! cellular response to alcohol
is_a: GO:1901655 ! cellular response to ketone
created_by: midori
creation_date: 2009-12-11T03:57:44Z

[Term]
id: GO:0071387
name: cellular response to cortisol stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisol stimulus. Cortisol is the major natural glucocorticoid synthesized in the zona fasciculata of the adrenal cortex; it affects the metabolism of glucose, protein, and fats and has appreciable mineralocorticoid activity. It also regulates the immune system and affects many other functions." [GOC:mah]
synonym: "cellular response to hydrocortisone stimulus" EXACT [GOC:mah]
is_a: GO:0051414 ! response to cortisol
is_a: GO:0071385 ! cellular response to glucocorticoid stimulus
is_a: GO:0097306 ! cellular response to alcohol
is_a: GO:1901655 ! cellular response to ketone
created_by: midori
creation_date: 2009-12-11T03:57:55Z

[Term]
id: GO:0071388
name: cellular response to cortisone stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisone stimulus. Cortisone is a natural glucocorticoid steroid hormone that is metabolically convertible to cortisol. Cortisone is synthesized from cholesterol in the cortex of the adrenal gland under the stimulation of adrenocorticotropin hormone (ACTH). The main physiological effect of cortisone is on carbohydrate metabolism; it can stimulate increased glucose release from the liver, increased liver glycogen synthesis, and decreased utilization of glucose by the tissues." [GOC:mah]
is_a: GO:0051413 ! response to cortisone
is_a: GO:0071385 ! cellular response to glucocorticoid stimulus
is_a: GO:0097306 ! cellular response to alcohol
is_a: GO:1901655 ! cellular response to ketone
created_by: midori
creation_date: 2009-12-11T03:57:59Z

[Term]
id: GO:0071389
name: cellular response to mineralocorticoid stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mineralocorticoid stimulus. Mineralocorticoids are hormonal C21 corticosteroids synthesized from cholesterol and characterized by their similarity to aldosterone. Mineralocorticoids act primarily on water and electrolyte balance." [GOC:mah]
is_a: GO:0051385 ! response to mineralocorticoid
is_a: GO:0071384 ! cellular response to corticosteroid stimulus
created_by: midori
creation_date: 2009-12-11T03:59:02Z

[Term]
id: GO:0071390
name: cellular response to ecdysone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ecdysone stimulus." [GOC:mah]
is_a: GO:0035075 ! response to ecdysone
is_a: GO:0036315 ! cellular response to sterol
is_a: GO:1901655 ! cellular response to ketone
created_by: midori
creation_date: 2009-12-11T04:03:57Z

[Term]
id: GO:0071391
name: cellular response to estrogen stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics." [GOC:mah]
synonym: "cellular response to oestrogen stimulus" EXACT [GOC:mah]
is_a: GO:0043627 ! response to estrogen
is_a: GO:0071383 ! cellular response to steroid hormone stimulus
created_by: midori
creation_date: 2009-12-11T04:09:56Z

[Term]
id: GO:0071392
name: cellular response to estradiol stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen." [GOC:mah]
synonym: "cellular response to E2 stimulus" EXACT [GOC:mah]
is_a: GO:0032355 ! response to estradiol
is_a: GO:0071391 ! cellular response to estrogen stimulus
is_a: GO:0097306 ! cellular response to alcohol
created_by: midori
creation_date: 2009-12-11T04:10:31Z

[Term]
id: GO:0071393
name: cellular response to progesterone stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus." [GOC:mah]
is_a: GO:0032570 ! response to progesterone
is_a: GO:0071383 ! cellular response to steroid hormone stimulus
is_a: GO:1901655 ! cellular response to ketone
created_by: midori
creation_date: 2009-12-11T04:11:13Z

[Term]
id: GO:0071394
name: cellular response to testosterone stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus." [GOC:mah]
is_a: GO:0033574 ! response to testosterone
is_a: GO:0071383 ! cellular response to steroid hormone stimulus
is_a: GO:0097306 ! cellular response to alcohol
is_a: GO:1901655 ! cellular response to ketone
created_by: midori
creation_date: 2009-12-11T04:11:29Z

[Term]
id: GO:0071395
name: cellular response to jasmonic acid stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus." [GOC:mah]
is_a: GO:0009753 ! response to jasmonic acid
is_a: GO:0032870 ! cellular response to hormone stimulus
is_a: GO:0071229 ! cellular response to acid chemical
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: midori
creation_date: 2009-12-11T04:13:34Z

[Term]
id: GO:0071396
name: cellular response to lipid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus." [GOC:mah]
is_a: GO:0033993 ! response to lipid
is_a: GO:0071310 ! cellular response to organic substance
created_by: midori
creation_date: 2009-12-11T04:37:10Z

[Term]
id: GO:0071397
name: cellular response to cholesterol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus." [GOC:mah]
is_a: GO:0036315 ! cellular response to sterol
is_a: GO:0070723 ! response to cholesterol
created_by: midori
creation_date: 2009-12-11T04:39:31Z

[Term]
id: GO:0071398
name: cellular response to fatty acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus." [GOC:mah]
is_a: GO:0070542 ! response to fatty acid
is_a: GO:0071229 ! cellular response to acid chemical
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: midori
creation_date: 2009-12-11T04:39:56Z

[Term]
id: GO:0071399
name: cellular response to linoleic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a linoleic acid stimulus." [GOC:mah]
synonym: "cellular response to linoleate" EXACT [GOC:mah]
is_a: GO:0070543 ! response to linoleic acid
is_a: GO:0071398 ! cellular response to fatty acid
created_by: midori
creation_date: 2009-12-11T04:40:22Z

[Term]
id: GO:0071400
name: cellular response to oleic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oleic acid stimulus." [GOC:mah]
synonym: "cellular response to oleate" EXACT [GOC:mah]
is_a: GO:0034201 ! response to oleic acid
is_a: GO:0071398 ! cellular response to fatty acid
created_by: midori
creation_date: 2009-12-11T04:40:38Z

[Term]
id: GO:0071401
name: cellular response to triglyceride
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triglyceride stimulus." [GOC:mah]
synonym: "cellular response to triacylglyceride" EXACT [GOC:mah]
synonym: "cellular response to triacylglycerol" EXACT [GOC:mah]
is_a: GO:0034014 ! response to triglyceride
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: midori
creation_date: 2009-12-11T04:40:56Z

[Term]
id: GO:0071402
name: cellular response to lipoprotein particle stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoprotein particle stimulus." [GOC:mah]
is_a: GO:0055094 ! response to lipoprotein particle
is_a: GO:0071310 ! cellular response to organic substance
is_a: GO:0071495 ! cellular response to endogenous stimulus
created_by: midori
creation_date: 2009-12-14T02:48:51Z

[Term]
id: GO:0071403
name: cellular response to high density lipoprotein particle stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high density lipoprotein particle stimulus." [GOC:mah]
is_a: GO:0055099 ! response to high density lipoprotein particle
is_a: GO:0071402 ! cellular response to lipoprotein particle stimulus
created_by: midori
creation_date: 2009-12-14T02:51:43Z

[Term]
id: GO:0071404
name: cellular response to low-density lipoprotein particle stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low-density lipoprotein particle stimulus." [GOC:mah]
is_a: GO:0055098 ! response to low-density lipoprotein particle
is_a: GO:0071402 ! cellular response to lipoprotein particle stimulus
created_by: midori
creation_date: 2009-12-14T02:51:57Z

[Term]
id: GO:0071405
name: cellular response to methanol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methanol stimulus." [GOC:mah]
is_a: GO:0033986 ! response to methanol
is_a: GO:0071229 ! cellular response to acid chemical
is_a: GO:0097306 ! cellular response to alcohol
created_by: midori
creation_date: 2009-12-14T02:54:44Z

[Term]
id: GO:0071406
name: cellular response to methylmercury
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylmercury stimulus." [GOC:mah]
synonym: "cellular response to CH3-Hg+" EXACT [GOC:mah]
synonym: "cellular response to MeHg+" EXACT [GOC:mah]
is_a: GO:0051597 ! response to methylmercury
is_a: GO:0071310 ! cellular response to organic substance
created_by: midori
creation_date: 2009-12-14T02:55:12Z

[Term]
id: GO:0071407
name: cellular response to organic cyclic compound
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus." [GOC:mah]
synonym: "cellular response to organic cyclic substance" EXACT [GOC:mah]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0071310 ! cellular response to organic substance
created_by: midori
creation_date: 2009-12-14T02:55:58Z

[Term]
id: GO:0071408
name: cellular response to cycloalkane
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cycloalkane stimulus. A cycloalkane is a cyclic saturated hydrocarbon having the general formula CnH2n." [GOC:mah]
is_a: GO:0014071 ! response to cycloalkane
is_a: GO:0071407 ! cellular response to organic cyclic compound
created_by: midori
creation_date: 2009-12-14T02:57:15Z

[Term]
id: GO:0071409
name: cellular response to cycloheximide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cycloheximide stimulus. Cycloheximide (actidione) is an antibiotic produced by some Streptomyces species which interferes with protein synthesis in eukaryotes." [GOC:mah]
synonym: "cellular response to actidione" EXACT [GOC:mah]
is_a: GO:0046898 ! response to cycloheximide
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:0097306 ! cellular response to alcohol
is_a: GO:1901655 ! cellular response to ketone
created_by: midori
creation_date: 2009-12-14T02:57:24Z

[Term]
id: GO:0071410
name: cellular response to cyclopentenone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclopentenone stimulus. Cyclopentenones are oxylipins derived from polyunsaturated fatty acids. They are structurally similar to jasmonic acid, but contain a reactive unsaturated carbonyl structure in the cyclo-ring. Cyclopentenones include phytoprostanes and 12-oxo-phytodienoic acid." [GOC:mah]
is_a: GO:0010583 ! response to cyclopentenone
is_a: GO:0071407 ! cellular response to organic cyclic compound
created_by: midori
creation_date: 2009-12-14T03:09:49Z

[Term]
id: GO:0071411
name: cellular response to fluoxetine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluoxetine stimulus. Fluoxetine increases the extracellular level of the neurotransmitter serotonin by inhibiting its reuptake into the presynaptic cell, increasing the level of serotonin available to bind to the postsynaptic receptor." [GOC:mah, GOC:pr]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
is_a: GO:0014076 ! response to fluoxetine
is_a: GO:0035690 ! cellular response to drug
is_a: GO:0071362 ! cellular response to ether
is_a: GO:0071407 ! cellular response to organic cyclic compound
created_by: midori
creation_date: 2009-12-14T03:09:58Z

[Term]
id: GO:0071412
name: cellular response to genistein
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a genistein stimulus." [GOC:mah]
is_a: GO:0033595 ! response to genistein
is_a: GO:0071391 ! cellular response to estrogen stimulus
is_a: GO:0071413 ! cellular response to hydroxyisoflavone
created_by: midori
creation_date: 2009-12-14T03:10:04Z

[Term]
id: GO:0071413
name: cellular response to hydroxyisoflavone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyisoflavone stimulus." [GOC:mah]
is_a: GO:0033594 ! response to hydroxyisoflavone
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901655 ! cellular response to ketone
created_by: midori
creation_date: 2009-12-14T03:10:09Z

[Term]
id: GO:0071414
name: cellular response to methotrexate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase." [GOC:mah]
is_a: GO:0031427 ! response to methotrexate
is_a: GO:0071229 ! cellular response to acid chemical
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: midori
creation_date: 2009-12-14T03:10:30Z

[Term]
id: GO:0071415
name: cellular response to purine-containing compound
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purine-containing compound stimulus." [CHEBI:26401, GOC:mah]
synonym: "cellular response to purine" RELATED [GOC:curators]
is_a: GO:0014074 ! response to purine-containing compound
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
created_by: midori
creation_date: 2009-12-14T03:12:20Z

[Term]
id: GO:0071416
name: cellular response to tropane
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tropane stimulus. Tropane is a nitrogenous bicyclic organic compound mainly known for a group of alkaloids derived from it (called tropane alkaloids), which include, among others, atropine and cocaine." [GOC:mah]
is_a: GO:0014073 ! response to tropane
is_a: GO:0071312 ! cellular response to alkaloid
is_a: GO:0071407 ! cellular response to organic cyclic compound
created_by: midori
creation_date: 2009-12-14T03:12:24Z

[Term]
id: GO:0071417
name: cellular response to organonitrogen compound
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond." [CHEBI:35352, GOC:mah]
synonym: "cellular response to organic nitrogen" EXACT [GOC:mah]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0071310 ! cellular response to organic substance
is_a: GO:0071495 ! cellular response to endogenous stimulus
is_a: GO:1901699 ! cellular response to nitrogen compound
created_by: midori
creation_date: 2009-12-14T04:07:27Z

[Term]
id: GO:0071418
name: cellular response to amine stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups." [GOC:mah]
is_a: GO:0014075 ! response to amine
is_a: GO:0071417 ! cellular response to organonitrogen compound
created_by: midori
creation_date: 2009-12-14T04:08:17Z

[Term]
id: GO:0071419
name: cellular response to amphetamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine." [GOC:mah]
is_a: GO:0001975 ! response to amphetamine
is_a: GO:0071418 ! cellular response to amine stimulus
created_by: midori
creation_date: 2009-12-14T04:09:02Z

[Term]
id: GO:0071420
name: cellular response to histamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histamine stimulus. Histamine, the biogenic amine 2-(1H-imidazol-4-yl)ethanamine, is involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter." [GOC:mah]
synonym: "cellular response to histamine stimulus" EXACT [GOC:mah]
is_a: GO:0034776 ! response to histamine
is_a: GO:0071242 ! cellular response to ammonium ion
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
created_by: midori
creation_date: 2009-12-14T04:09:25Z

[Term]
id: GO:0071421
name: manganese ion transmembrane transport
namespace: biological_process
def: "A process in which a manganese ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "manganese ion membrane transport" EXACT []
synonym: "transmembrane manganese transport" EXACT [GOC:mah]
is_a: GO:0006828 ! manganese ion transport
is_a: GO:0098662 ! inorganic cation transmembrane transport
created_by: midori
creation_date: 2009-12-15T02:41:31Z

[Term]
id: GO:0071422
name: succinate transmembrane transport
namespace: biological_process
def: "A process in which a succinate ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "succinate membrane transport" EXACT []
synonym: "transmembrane succinate transport" EXACT [GOC:mah]
is_a: GO:0015744 ! succinate transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport
created_by: midori
creation_date: 2009-12-15T03:29:44Z

[Term]
id: GO:0071423
name: malate transmembrane transport
namespace: biological_process
def: "A process in which a malate ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "malate membrane transport" EXACT []
synonym: "transmembrane malate transport" EXACT [GOC:mah]
is_a: GO:0015743 ! malate transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport
created_by: midori
creation_date: 2009-12-15T03:31:37Z

[Term]
id: GO:0071424
name: rRNA (cytosine-N4-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N4-methylcytosine." [GOC:imk, PMID:19965768]
subset: gosubset_prok
xref: EC:2.1.1.-
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0016434 ! rRNA (cytosine) methyltransferase activity
created_by: midori
creation_date: 2009-12-15T03:46:52Z

[Term]
id: GO:0071425
name: hematopoietic stem cell proliferation
namespace: biological_process
def: "The expansion of a hematopoietic stem cell population by cell division. A hematopoietic stem cell is a stem cell from which all cells of the lymphoid and myeloid lineages develop." [CL:0000037, GOC:add, GOC:BHF, GOC:mah, GOC:rl]
synonym: "hemopoietic stem cell proliferation" EXACT []
is_a: GO:0072089 ! stem cell proliferation
relationship: part_of GO:0030097 ! hemopoiesis
created_by: midori
creation_date: 2009-12-16T10:22:52Z

[Term]
id: GO:0071426
name: ribonucleoprotein complex export from nucleus
namespace: biological_process
def: "The directed movement of a ribonucleoprotein complex from the nucleus to the cytoplasm." [GOC:mah]
synonym: "ribonucleoprotein complex export from cell nucleus" EXACT [GOC:mah]
synonym: "ribonucleoprotein complex nucleus export" EXACT [GOC:mah]
synonym: "ribonucleoprotein complex transport from nucleus to cytoplasm" EXACT [GOC:mah]
synonym: "RNP export from nucleus" EXACT [GOC:mah]
is_a: GO:0051168 ! nuclear export
is_a: GO:1902582 ! single-organism intracellular transport
relationship: has_part GO:0006405 ! RNA export from nucleus
relationship: part_of GO:0071166 ! ribonucleoprotein complex localization
created_by: midori
creation_date: 2009-12-16T10:13:01Z

[Term]
id: GO:0071427
name: mRNA-containing ribonucleoprotein complex export from nucleus
namespace: biological_process
def: "The directed movement of a ribonucleoprotein complex that contains messenger RNA from the nucleus to the cytoplasm." [GOC:mah]
synonym: "mRNA-containing ribonucleoprotein complex export from cell nucleus" EXACT [GOC:mah]
synonym: "mRNA-containing ribonucleoprotein complex nucleus export" EXACT [GOC:mah]
synonym: "mRNA-containing ribonucleoprotein complex transport from nucleus to cytoplasm" EXACT [GOC:mah]
synonym: "mRNA-containing RNP export from nucleus" EXACT [GOC:mah]
is_a: GO:0071426 ! ribonucleoprotein complex export from nucleus
created_by: midori
creation_date: 2009-12-16T10:13:59Z

[Term]
id: GO:0071428
name: rRNA-containing ribonucleoprotein complex export from nucleus
namespace: biological_process
def: "The directed movement of a ribonucleoprotein complex that contains ribosomal RNA from the nucleus to the cytoplasm." [GOC:mah]
synonym: "rRNA-containing ribonucleoprotein complex export from cell nucleus" EXACT [GOC:mah]
synonym: "rRNA-containing ribonucleoprotein complex nucleus export" EXACT [GOC:mah]
synonym: "rRNA-containing ribonucleoprotein complex transport from nucleus to cytoplasm" EXACT [GOC:mah]
synonym: "rRNA-containing RNP export from nucleus" EXACT [GOC:mah]
is_a: GO:0071426 ! ribonucleoprotein complex export from nucleus
created_by: midori
creation_date: 2009-12-16T10:15:07Z

[Term]
id: GO:0071429
name: snRNA-containing ribonucleoprotein complex export from nucleus
namespace: biological_process
def: "The directed movement of a ribonucleoprotein complex that contains small nuclear RNA from the nucleus to the cytoplasm." [GOC:mah]
synonym: "snRNA-containing ribonucleoprotein complex export from cell nucleus" EXACT [GOC:mah]
synonym: "snRNA-containing ribonucleoprotein complex nucleus export" EXACT [GOC:mah]
synonym: "snRNA-containing ribonucleoprotein complex transport from nucleus to cytoplasm" EXACT [GOC:mah]
synonym: "snRNA-containing RNP export from nucleus" EXACT [GOC:mah]
is_a: GO:0071426 ! ribonucleoprotein complex export from nucleus
relationship: has_part GO:0006408 ! snRNA export from nucleus
created_by: midori
creation_date: 2009-12-16T10:15:38Z

[Term]
id: GO:0071430
name: pre-miRNA-containing ribonucleoprotein complex export from nucleus
namespace: biological_process
def: "The directed movement of a ribonucleoprotein complex that contains pre-microRNA from the nucleus to the cytoplasm." [GOC:mah, GOC:sl]
synonym: "pre-microRNA-containing ribonucleoprotein complex export from cell nucleus" EXACT [GOC:mah]
synonym: "pre-microRNA-containing ribonucleoprotein complex export from nucleus" EXACT []
synonym: "pre-microRNA-containing ribonucleoprotein complex nucleus export" EXACT [GOC:mah]
synonym: "pre-microRNA-containing ribonucleoprotein complex transport from nucleus to cytoplasm" EXACT [GOC:mah]
synonym: "pre-microRNA-containing RNP export from nucleus" EXACT [GOC:mah]
is_a: GO:0071426 ! ribonucleoprotein complex export from nucleus
relationship: has_part GO:0035281 ! pre-miRNA export from nucleus
created_by: midori
creation_date: 2009-12-16T10:26:16Z

[Term]
id: GO:0071431
name: tRNA-containing ribonucleoprotein complex export from nucleus
namespace: biological_process
def: "The directed movement of a ribonucleoprotein complex that contains transfer RNA from the nucleus to the cytoplasm." [GOC:mah]
synonym: "tRNA-containing ribonucleoprotein complex export from cell nucleus" EXACT [GOC:mah]
synonym: "tRNA-containing ribonucleoprotein complex nucleus export" EXACT [GOC:mah]
synonym: "tRNA-containing ribonucleoprotein complex transport from nucleus to cytoplasm" EXACT [GOC:mah]
synonym: "tRNA-containing RNP export from nucleus" EXACT [GOC:mah]
is_a: GO:0071426 ! ribonucleoprotein complex export from nucleus
created_by: midori
creation_date: 2009-12-16T10:27:03Z

[Term]
id: GO:0071432
name: peptide mating pheromone maturation involved in conjugation with cellular fusion
namespace: biological_process
def: "The formation of a mature peptide mating pheromone by proteolysis and/or modification of a peptide precursor, occurring in the context of conjugation with cellular fusion." [GOC:mah]
synonym: "a-factor processing (proteolytic)" NARROW [GOC:vw]
synonym: "alpha-factor maturation" NARROW [GOC:vw]
synonym: "mating-type peptide pheromone maturation involved in conjugation with cellular fusion" EXACT [GOC:mah]
synonym: "peptide mating pheromone formation involved in conjugation with cellular fusion" EXACT [GOC:mah]
synonym: "peptide mating pheromone processing involved in conjugation with cellular fusion" EXACT [GOC:mah]
is_a: GO:0007323 ! peptide pheromone maturation
is_a: GO:0022414 ! reproductive process
relationship: part_of GO:0000747 ! conjugation with cellular fusion
created_by: midori
creation_date: 2009-12-16T10:46:50Z

[Term]
id: GO:0071433
name: cell wall repair
namespace: biological_process
def: "A process of cell wall organization that results in the restoration of the cell wall following damage." [GOC:mah, GOC:vw]
is_a: GO:0071555 ! cell wall organization
created_by: midori
creation_date: 2009-12-16T11:00:50Z

[Term]
id: GO:0071434
name: cell chemotaxis to angiotensin
namespace: biological_process
def: "The directed movement of a motile cell in response to the presence of angiotensin." [GOC:mah]
synonym: "angiotensin mediated chemotaxis" BROAD [GOC:mah]
synonym: "angiotensin-mediated cell chemotaxis" EXACT [GOC:mah]
is_a: GO:0060326 ! cell chemotaxis
created_by: midori
creation_date: 2009-12-16T11:07:15Z

[Term]
id: GO:0071435
name: potassium ion export
namespace: biological_process
def: "The directed movement of potassium ions out of a cell or organelle." [GOC:mah]
synonym: "potassium export" EXACT [GOC:mah]
is_a: GO:0071805 ! potassium ion transmembrane transport
created_by: midori
creation_date: 2009-12-16T11:10:45Z

[Term]
id: GO:0071436
name: sodium ion export
namespace: biological_process
def: "The directed movement of sodium ions out of a cell or organelle." [GOC:mah]
synonym: "sodium export" EXACT [GOC:mah]
is_a: GO:0035725 ! sodium ion transmembrane transport
created_by: midori
creation_date: 2009-12-16T11:13:55Z

[Term]
id: GO:0071437
name: invadopodium
namespace: cellular_component
def: "A cell projection that emerges from the ECM-facing surface of a cell, is enriched in actin and associated cytoskeletal proteins, and displays localized proteolytic activity toward the substrate." [GOC:mah, PMID:16651416, PMID:19491051, PMID:19931459]
is_a: GO:0042995 ! cell projection
created_by: midori
creation_date: 2009-12-16T02:19:58Z

[Term]
id: GO:0071438
name: invadopodium membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding an invadopodium." [GOC:mah]
is_a: GO:0031253 ! cell projection membrane
relationship: part_of GO:0071437 ! invadopodium
created_by: midori
creation_date: 2009-12-16T03:00:30Z

[Term]
id: GO:0071439
name: clathrin complex
namespace: cellular_component
def: "A protein complex that consists of three clathrin heavy chains and three clathrin light chains, organized into a symmetrical three-legged structure called a triskelion. In clathrin-coated vesicles clathrin is the main component of the coat and forms a polymeric mechanical scaffold on the vesicle surface." [GOC:mah, PMID:16493411]
synonym: "clathrin triskelion" EXACT [GOC:mah]
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0030118 ! clathrin coat
created_by: midori
creation_date: 2009-12-16T03:17:58Z

[Term]
id: GO:0071440
name: regulation of histone H3-K14 acetylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the addition of an acetyl group to histone H3 at position 14 of the histone." [GOC:mah]
synonym: "regulation of histone H3 acetylation at K14" EXACT [GOC:mah]
synonym: "regulation of histone H3K14 acetylation" EXACT [GOC:mah]
is_a: GO:0035065 ! regulation of histone acetylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044154 ! histone H3-K14 acetylation
relationship: regulates GO:0044154 ! histone H3-K14 acetylation
created_by: midori
creation_date: 2009-12-16T03:24:53Z

[Term]
id: GO:0071441
name: negative regulation of histone H3-K14 acetylation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of an acetyl group to histone H3 at position 14 of the histone." [GOC:mah]
synonym: "down regulation of histone H3-K14 acetylation" EXACT [GOC:mah]
synonym: "down-regulation of histone H3-K14 acetylation" EXACT [GOC:mah]
synonym: "downregulation of histone H3-K14 acetylation" EXACT [GOC:mah]
synonym: "inhibition of histone H3-K14 acetylation" NARROW [GOC:mah]
synonym: "negative regulation of histone H3 acetylation at K14" EXACT [GOC:mah]
synonym: "negative regulation of histone H3K14 acetylation" EXACT [GOC:mah]
is_a: GO:0035067 ! negative regulation of histone acetylation
is_a: GO:0071440 ! regulation of histone H3-K14 acetylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044154 ! histone H3-K14 acetylation
relationship: negatively_regulates GO:0044154 ! histone H3-K14 acetylation
created_by: midori
creation_date: 2009-12-16T03:28:23Z

[Term]
id: GO:0071442
name: positive regulation of histone H3-K14 acetylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to histone H3 at position 14 of the histone." [GOC:mah]
synonym: "activation of histone H3-K14 acetylation" NARROW [GOC:mah]
synonym: "positive regulation of histone H3 acetylation at K14" EXACT [GOC:mah]
synonym: "positive regulation of histone H3K14 acetylation" EXACT [GOC:mah]
synonym: "stimulation of histone H3-K14 acetylation" NARROW [GOC:mah]
synonym: "up regulation of histone H3-K14 acetylation" EXACT [GOC:mah]
synonym: "up-regulation of histone H3-K14 acetylation" EXACT [GOC:mah]
synonym: "upregulation of histone H3-K14 acetylation" EXACT [GOC:mah]
is_a: GO:0035066 ! positive regulation of histone acetylation
is_a: GO:0071440 ! regulation of histone H3-K14 acetylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044154 ! histone H3-K14 acetylation
relationship: positively_regulates GO:0044154 ! histone H3-K14 acetylation
created_by: midori
creation_date: 2009-12-16T03:29:49Z

[Term]
id: GO:0071443
name: tDNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with DNA sequences encoding transfer RNA." [GOC:mah]
is_a: GO:1990837 ! sequence-specific double-stranded DNA binding
created_by: midori
creation_date: 2009-12-16T03:47:31Z

[Term]
id: GO:0071444
name: cellular response to pheromone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus." [GOC:mah]
subset: gosubset_prok
synonym: "cellular pheromone response" EXACT [GOC:mah]
is_a: GO:0019236 ! response to pheromone
is_a: GO:0071310 ! cellular response to organic substance
created_by: midori
creation_date: 2009-12-16T04:05:33Z

[Term]
id: GO:0071445
name: obsolete cellular response to protein stimulus
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein stimulus." [GOC:mah]
comment: This term was made obsolete because more specific terms exist.
subset: gosubset_prok
synonym: "cellular response to protein stimulus" EXACT []
is_obsolete: true
consider: GO:0032870
consider: GO:0034620
consider: GO:0071218
consider: GO:0071345
consider: GO:0071363
created_by: midori
creation_date: 2009-12-16T04:12:04Z

[Term]
id: GO:0071446
name: cellular response to salicylic acid stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salicylic acid stimulus." [GOC:mah]
synonym: "cellular response to salicylate stimulus" EXACT [GOC:dph]
is_a: GO:0009751 ! response to salicylic acid
is_a: GO:0071229 ! cellular response to acid chemical
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: midori
creation_date: 2009-12-16T04:14:16Z

[Term]
id: GO:0071447
name: cellular response to hydroperoxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH." [GOC:mah]
subset: gosubset_prok
is_a: GO:0033194 ! response to hydroperoxide
is_a: GO:0034599 ! cellular response to oxidative stress
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: midori
creation_date: 2009-12-16T04:16:42Z

[Term]
id: GO:0071448
name: cellular response to alkyl hydroperoxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkyl hydroperoxide stimulus. Alkyl hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH, where the substituent is an alkyl group." [GOC:mah]
is_a: GO:0033195 ! response to alkyl hydroperoxide
is_a: GO:0071447 ! cellular response to hydroperoxide
created_by: midori
creation_date: 2009-12-16T04:17:52Z

[Term]
id: GO:0071449
name: cellular response to lipid hydroperoxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid hydroperoxide stimulus. Lipid hydroperoxide is the highly reactive primary oxygenated products of polyunsaturated fatty acids." [GOC:mah]
subset: gosubset_prok
synonym: "cellular response to LHPO" EXACT [GOC:mah]
is_a: GO:0006982 ! response to lipid hydroperoxide
is_a: GO:0071447 ! cellular response to hydroperoxide
created_by: midori
creation_date: 2009-12-16T04:17:57Z

[Term]
id: GO:0071450
name: cellular response to oxygen radical
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen radical stimulus. An oxygen radical is any oxygen species that carries a free electron; examples include hydroxyl radicals and the superoxide anion." [GOC:mah]
subset: gosubset_prok
is_a: GO:0000305 ! response to oxygen radical
is_a: GO:0034614 ! cellular response to reactive oxygen species
created_by: midori
creation_date: 2009-12-16T04:38:52Z

[Term]
id: GO:0071451
name: cellular response to superoxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion." [GOC:mah]
subset: gosubset_prok
is_a: GO:0000303 ! response to superoxide
is_a: GO:0071450 ! cellular response to oxygen radical
created_by: midori
creation_date: 2009-12-16T04:39:14Z

[Term]
id: GO:0071452
name: cellular response to singlet oxygen
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a singlet oxygen stimulus. Singlet oxygen is a dioxygen (O2) molecule in which two 2p electrons have similar spin. Singlet oxygen is more highly reactive than the form in which these electrons are of opposite spin, and it is produced in mutant chloroplasts lacking carotenoids and by leukocytes during metabolic burst." [GOC:mah]
subset: gosubset_prok
is_a: GO:0000304 ! response to singlet oxygen
is_a: GO:0034614 ! cellular response to reactive oxygen species
created_by: midori
creation_date: 2009-12-16T04:39:46Z

[Term]
id: GO:0071453
name: cellular response to oxygen levels
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:mah]
synonym: "cellular response to oxygen" RELATED [GOC:al]
is_a: GO:0070482 ! response to oxygen levels
is_a: GO:0070887 ! cellular response to chemical stimulus
created_by: midori
creation_date: 2009-12-16T04:43:59Z

[Term]
id: GO:0071454
name: cellular response to anoxia
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating a decline in oxygen levels to trace amounts, <0.1%." [GOC:mah]
comment: Note that this term should not be confused with 'cellular response to hypoxia ; GO:0071456'.
synonym: "cellular response to anaerobic conditions" EXACT [GOC:elh]
synonym: "cellular response to anoxic stress" EXACT [GOC:mah]
is_a: GO:0033554 ! cellular response to stress
is_a: GO:0034059 ! response to anoxia
is_a: GO:0036294 ! cellular response to decreased oxygen levels
created_by: midori
creation_date: 2009-12-16T04:44:20Z

[Term]
id: GO:0071455
name: cellular response to hyperoxia
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension." [GOC:mah]
synonym: "cellular response to hyperoxic stress" EXACT [GOC:mah]
synonym: "cellular response to increased oxygen tension" EXACT [GOC:mah]
is_a: GO:0033554 ! cellular response to stress
is_a: GO:0036295 ! cellular response to increased oxygen levels
is_a: GO:0055093 ! response to hyperoxia
created_by: midori
creation_date: 2009-12-16T04:44:41Z

[Term]
id: GO:0071456
name: cellular response to hypoxia
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah]
comment: Note that this term should not be confused with 'cellular response to anoxia ; GO:0071454'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%.
synonym: "cellular response to hypoxic stress" EXACT [GOC:mah]
synonym: "cellular response to lowered oxygen tension" EXACT [GOC:mah]
is_a: GO:0001666 ! response to hypoxia
is_a: GO:0033554 ! cellular response to stress
is_a: GO:0036294 ! cellular response to decreased oxygen levels
created_by: midori
creation_date: 2009-12-16T04:45:20Z

[Term]
id: GO:0071457
name: cellular response to ozone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ozone stimulus." [GOC:mah]
is_a: GO:0010193 ! response to ozone
is_a: GO:0034614 ! cellular response to reactive oxygen species
is_a: GO:0071229 ! cellular response to acid chemical
created_by: midori
creation_date: 2009-12-16T04:45:59Z

[Term]
id: GO:0071458
name: integral component of cytoplasmic side of endoplasmic reticulum membrane
namespace: cellular_component
def: "The component of the endoplasmic reticulum membrane consisting of the gene products that penetrate only the cytoplasmic side of the membrane." [GOC:dos, GOC:mah]
synonym: "integral to cytosolic leaflet of endoplasmic reticulum membrane" EXACT [GOC:ab]
synonym: "integral to cytosolic side of endoplasmic reticulum membrane" EXACT []
synonym: "integral to cytosolic side of ER membrane" EXACT [GOC:mah]
synonym: "integral to ER membrane, cytosolic side" EXACT [GOC:vw]
is_a: GO:0030176 ! integral component of endoplasmic reticulum membrane
intersection_of: GO:0030176 ! integral component of endoplasmic reticulum membrane
intersection_of: part_of GO:0098554 ! cytoplasmic side of endoplasmic reticulum membrane
relationship: part_of GO:0098554 ! cytoplasmic side of endoplasmic reticulum membrane
created_by: midori
creation_date: 2009-12-17T01:43:33Z

[Term]
id: GO:0071459
name: protein localization to chromosome, centromeric region
namespace: biological_process
def: "Any process in which a protein is transported to, or maintained at, the centromeric region of a chromosome." [GOC:mah]
synonym: "protein localisation to chromosome, centromeric region" EXACT [GOC:mah]
synonym: "protein localization to centromere" EXACT [GOC:mah]
synonym: "protein localization to chromosome, centric region" EXACT [GOC:mah]
is_a: GO:0034502 ! protein localization to chromosome
created_by: midori
creation_date: 2009-12-17T02:11:23Z

[Term]
id: GO:0071460
name: cellular response to cell-matrix adhesion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of cell-matrix adhesion." [GOC:sl, PMID:11425869]
is_a: GO:0031668 ! cellular response to extracellular stimulus
created_by: midori
creation_date: 2009-12-17T02:25:45Z

[Term]
id: GO:0071461
name: cellular response to redox state
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating redox state. Redox state refers to the balance of oxidized versus reduced forms of electron donors and acceptors in an organelle, cell or organ; plastoquinone, glutathione (GSH/GSSG), and nicotinamide nucleotides (NAD+/NADH and NADP+/NADPH) are among the most important." [GOC:mah]
subset: gosubset_prok
synonym: "cellular redox signal response" EXACT [GOC:mah]
is_a: GO:0051775 ! response to redox state
created_by: midori
creation_date: 2009-12-18T11:30:21Z

[Term]
id: GO:0071462
name: cellular response to water stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of water." [GOC:mah]
subset: gosubset_prok
is_a: GO:0009415 ! response to water
is_a: GO:0071214 ! cellular response to abiotic stimulus
is_a: GO:0071229 ! cellular response to acid chemical
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: midori
creation_date: 2009-12-18T11:32:44Z

[Term]
id: GO:0071463
name: cellular response to humidity
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a humidity stimulus, moisture in the atmosphere." [GOC:mah]
is_a: GO:0009270 ! response to humidity
is_a: GO:0071462 ! cellular response to water stimulus
created_by: midori
creation_date: 2009-12-18T11:33:55Z

[Term]
id: GO:0071464
name: cellular response to hydrostatic pressure
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrostatic pressure stimulus. Hydrostatic pressure is the force acting on an object in a system where the fluid is at rest (as opposed to moving). The weight of the fluid above the object creates pressure on it." [GOC:mah]
synonym: "cellular response to biomechanical stress" BROAD [GOC:mah]
synonym: "cellular response to static fluid pressure" EXACT [GOC:mah]
is_a: GO:0033554 ! cellular response to stress
is_a: GO:0051599 ! response to hydrostatic pressure
is_a: GO:0071462 ! cellular response to water stimulus
created_by: midori
creation_date: 2009-12-18T11:34:07Z

[Term]
id: GO:0071465
name: cellular response to desiccation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desiccation stimulus, extreme dryness resulting from the prolonged deprivation of water." [GOC:mah]
subset: gosubset_prok
synonym: "desiccation tolerance" RELATED [GOC:mah]
is_a: GO:0009269 ! response to desiccation
is_a: GO:0042631 ! cellular response to water deprivation
created_by: midori
creation_date: 2009-12-18T11:35:19Z

[Term]
id: GO:0071466
name: cellular response to xenobiotic stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms." [GOC:mah]
subset: gosubset_prok
is_a: GO:0009410 ! response to xenobiotic stimulus
is_a: GO:0070887 ! cellular response to chemical stimulus
created_by: midori
creation_date: 2009-12-18T11:38:48Z

[Term]
id: GO:0071467
name: cellular response to pH
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution." [GOC:mah, http://en.wikipedia.org/wiki/PH]
subset: gosubset_prok
is_a: GO:0009268 ! response to pH
is_a: GO:0071214 ! cellular response to abiotic stimulus
created_by: midori
creation_date: 2009-12-18T11:41:54Z

[Term]
id: GO:0071468
name: cellular response to acidic pH
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution." [GOC:go_curators, GOC:mah, http://en.wikipedia.org/wiki/PH]
comment: This term should be used to annotate instances where a cell is responding to a chemical that is playing the role of an acid (e.g. proton donor) and therefore lowering the pH. If instead you wish to describe a response to a specific acid as a chemical, such as the anion portion of glutamate, please annotate to the appropriate child of GO:0071229 'cellular response to acid chemical'.
synonym: "cellular response to acidity" BROAD []
is_a: GO:0010447 ! response to acidic pH
is_a: GO:0071467 ! cellular response to pH
created_by: midori
creation_date: 2009-12-18T11:42:35Z

[Term]
id: GO:0071469
name: cellular response to alkaline pH
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH > 7. pH is a measure of the acidity or basicity of an aqueous solution." [GOC:go_curators, GOC:mah, http://en.wikipedia.org/wiki/PH]
synonym: "cellular response to alkalinity" BROAD []
synonym: "cellular response to basic pH" EXACT [GOC:mah]
is_a: GO:0010446 ! response to alkaline pH
is_a: GO:0071467 ! cellular response to pH
created_by: midori
creation_date: 2009-12-18T11:42:47Z

[Term]
id: GO:0071470
name: cellular response to osmotic stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:mah]
subset: gosubset_prok
synonym: "cellular osmotic response" EXACT [GOC:mah]
synonym: "cellular osmotic stress response" EXACT [GOC:mah]
is_a: GO:0006970 ! response to osmotic stress
is_a: GO:0033554 ! cellular response to stress
is_a: GO:0071214 ! cellular response to abiotic stimulus
created_by: midori
creation_date: 2009-12-18T11:45:33Z

[Term]
id: GO:0071471
name: cellular response to non-ionic osmotic stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of non-ionic solutes (e.g. mannitol, sorbitol) in the environment." [GOC:mah]
is_a: GO:0010335 ! response to non-ionic osmotic stress
is_a: GO:0071470 ! cellular response to osmotic stress
created_by: midori
creation_date: 2009-12-18T11:47:59Z

[Term]
id: GO:0071472
name: cellular response to salt stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:mah]
subset: gosubset_prok
synonym: "cellular response to ionic osmotic stress" EXACT [GOC:mah]
synonym: "cellular salinity response" EXACT [GOC:mah]
is_a: GO:0009651 ! response to salt stress
is_a: GO:0071470 ! cellular response to osmotic stress
created_by: midori
creation_date: 2009-12-18T11:48:23Z

[Term]
id: GO:0071473
name: cellular response to cation stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of cation stress, an increase or decrease in the concentration of positively charged ions in the environment." [GOC:mah]
subset: gosubset_prok
is_a: GO:0043157 ! response to cation stress
is_a: GO:0071472 ! cellular response to salt stress
created_by: midori
creation_date: 2009-12-18T11:49:46Z

[Term]
id: GO:0071474
name: cellular hyperosmotic response
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell." [GOC:mah]
synonym: "cellular HOG response" EXACT [GOC:mah]
synonym: "cellular hypertonic response" EXACT [GOC:mah]
synonym: "cellular response to hypertonicity" EXACT [GOC:mah, GOC:yaf]
is_a: GO:0006972 ! hyperosmotic response
is_a: GO:0071470 ! cellular response to osmotic stress
created_by: midori
creation_date: 2009-12-18T11:51:36Z

[Term]
id: GO:0071475
name: cellular hyperosmotic salinity response
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:mah]
synonym: "cellular response to hyperosmotic salt stress" EXACT [GOC:mah]
is_a: GO:0042538 ! hyperosmotic salinity response
is_a: GO:0071472 ! cellular response to salt stress
is_a: GO:0071474 ! cellular hyperosmotic response
created_by: midori
creation_date: 2009-12-18T11:52:06Z

[Term]
id: GO:0071476
name: cellular hypotonic response
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell." [GOC:mah]
synonym: "cellular hypo-osmotic response" EXACT [GOC:mah]
is_a: GO:0006971 ! hypotonic response
is_a: GO:0071470 ! cellular response to osmotic stress
created_by: midori
creation_date: 2009-12-18T11:52:59Z

[Term]
id: GO:0071477
name: cellular hypotonic salinity response
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:mah]
synonym: "cellular response to hypotonic salt stress" EXACT [GOC:mah]
is_a: GO:0042539 ! hypotonic salinity response
is_a: GO:0071472 ! cellular response to salt stress
is_a: GO:0071476 ! cellular hypotonic response
created_by: midori
creation_date: 2009-12-18T11:53:20Z

[Term]
id: GO:0071478
name: cellular response to radiation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation." [GOC:mah]
comment: Note that 'radiation' refers to electromagnetic radiation of any wavelength.
subset: gosubset_prok
synonym: "cellular response to electromagnetic radiation stimulus" EXACT [GOC:mah]
synonym: "cellular response to radiation stimulus" EXACT [GOC:mah]
is_a: GO:0009314 ! response to radiation
is_a: GO:0071214 ! cellular response to abiotic stimulus
created_by: midori
creation_date: 2009-12-18T01:59:37Z

[Term]
id: GO:0071479
name: cellular response to ionizing radiation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays." [GOC:mah]
synonym: "cellular response to ionising radiation" EXACT [GOC:mah]
synonym: "cellular response to ionizing radiation stimulus" EXACT [GOC:mah]
is_a: GO:0010212 ! response to ionizing radiation
is_a: GO:0071478 ! cellular response to radiation
created_by: midori
creation_date: 2009-12-18T02:00:31Z

[Term]
id: GO:0071480
name: cellular response to gamma radiation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum." [GOC:mah]
synonym: "cellular response to gamma ray" RELATED [GOC:mah]
synonym: "cellular response to gamma-ray photon" RELATED [GOC:mah]
is_a: GO:0010332 ! response to gamma radiation
is_a: GO:0071479 ! cellular response to ionizing radiation
created_by: midori
creation_date: 2009-12-18T02:00:50Z

[Term]
id: GO:0071481
name: cellular response to X-ray
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz)." [GOC:mah]
synonym: "cellular response to X-ray radiation stimulus" EXACT [GOC:mah]
is_a: GO:0010165 ! response to X-ray
is_a: GO:0071479 ! cellular response to ionizing radiation
created_by: midori
creation_date: 2009-12-18T02:00:59Z

[Term]
id: GO:0071482
name: cellular response to light stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]
subset: gosubset_prok
is_a: GO:0009416 ! response to light stimulus
is_a: GO:0071478 ! cellular response to radiation
created_by: midori
creation_date: 2009-12-18T02:03:49Z

[Term]
id: GO:0071483
name: cellular response to blue light
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a blue light stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm." [GOC:mah]
synonym: "cellular response to blue light stimulus" EXACT [GOC:mah]
is_a: GO:0009637 ! response to blue light
is_a: GO:0071482 ! cellular response to light stimulus
created_by: midori
creation_date: 2009-12-18T02:09:48Z

[Term]
id: GO:0071484
name: cellular response to light intensity
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light intensity stimulus." [GOC:mah]
is_a: GO:0009642 ! response to light intensity
is_a: GO:0071482 ! cellular response to light stimulus
created_by: midori
creation_date: 2009-12-18T02:11:03Z

[Term]
id: GO:0071485
name: cellular response to absence of light
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an absence of light stimuli." [GOC:mah]
synonym: "cellular response to darkness" RELATED []
is_a: GO:0009646 ! response to absence of light
is_a: GO:0071484 ! cellular response to light intensity
created_by: midori
creation_date: 2009-12-18T02:13:12Z

[Term]
id: GO:0071486
name: cellular response to high light intensity
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high light intensity stimulus." [GOC:mah]
is_a: GO:0009644 ! response to high light intensity
is_a: GO:0071484 ! cellular response to light intensity
created_by: midori
creation_date: 2009-12-18T02:13:23Z

[Term]
id: GO:0071487
name: cellular response to low light intensity stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low light intensity stimulus. Low light intensity is defined as a level of electromagnetic radiation at or below 0.1 micromols/m2." [GOC:mah]
is_a: GO:0009645 ! response to low light intensity stimulus
is_a: GO:0071484 ! cellular response to light intensity
created_by: midori
creation_date: 2009-12-18T02:13:29Z

[Term]
id: GO:0071488
name: cellular response to very low light intensity stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a very low light intensity stimulus. A very low light intensity stimulus is defined as a level of electromagnetic radiation below 0.001 mmol/m2/sec." [GOC:mah]
is_a: GO:0055122 ! response to very low light intensity stimulus
is_a: GO:0071484 ! cellular response to light intensity
created_by: midori
creation_date: 2009-12-18T02:13:40Z

[Term]
id: GO:0071489
name: cellular response to red or far red light
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red or far red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:mah]
is_a: GO:0009639 ! response to red or far red light
is_a: GO:0071482 ! cellular response to light stimulus
created_by: midori
creation_date: 2009-12-18T02:18:25Z

[Term]
id: GO:0071490
name: cellular response to far red light
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of far red light stimulus. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:mah]
synonym: "cellular response to far red light stimulus" EXACT [GOC:mah]
is_a: GO:0010218 ! response to far red light
is_a: GO:0071489 ! cellular response to red or far red light
created_by: midori
creation_date: 2009-12-18T02:19:40Z

[Term]
id: GO:0071491
name: cellular response to red light
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:mah]
synonym: "cellular response to red light stimulus" EXACT [GOC:mah]
is_a: GO:0010114 ! response to red light
is_a: GO:0071489 ! cellular response to red or far red light
created_by: midori
creation_date: 2009-12-18T02:19:47Z

[Term]
id: GO:0071492
name: cellular response to UV-A
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-A radiation stimulus. UV-A radiation (UV-A light) spans the wavelengths 315 to 400 nm." [GOC:mah]
synonym: "cellular response to UV-A light stimulus" EXACT [GOC:mah]
synonym: "cellular response to UV-A radiation stimulus" EXACT [GOC:mah]
synonym: "cellular response to UVA light stimulus" EXACT [GOC:mah]
synonym: "cellular response to UVA radiation stimulus" EXACT [GOC:mah]
is_a: GO:0034644 ! cellular response to UV
is_a: GO:0070141 ! response to UV-A
created_by: midori
creation_date: 2009-12-18T02:21:51Z

[Term]
id: GO:0071493
name: cellular response to UV-B
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 280 to 315 nm." [GOC:mah]
synonym: "cellular response to medium wave ultraviolet light stimulus" EXACT [GOC:mah]
synonym: "cellular response to medium wave ultraviolet radiation stimulus" EXACT [GOC:mah]
synonym: "cellular response to UV-B light stimulus" EXACT [GOC:mah]
synonym: "cellular response to UV-B radiation stimulus" EXACT [GOC:mah]
synonym: "cellular response to UVB light stimulus" EXACT [GOC:mah]
synonym: "cellular response to UVB radiation stimulus" EXACT [GOC:mah]
is_a: GO:0010224 ! response to UV-B
is_a: GO:0034644 ! cellular response to UV
created_by: midori
creation_date: 2009-12-18T02:21:56Z

[Term]
id: GO:0071494
name: cellular response to UV-C
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-C radiation stimulus. UV-C radiation (UV-C light) spans the wavelengths 100 to 280 nm." [GOC:mah]
synonym: "cellular response to germicidal ultraviolet light stimulus" EXACT [GOC:mah]
synonym: "cellular response to germicidal ultraviolet radiation stimulus" EXACT [GOC:mah]
synonym: "cellular response to shortwave ultraviolet light stimulus" EXACT [GOC:mah]
synonym: "cellular response to shortwave ultraviolet radiation stimulus" EXACT [GOC:mah]
synonym: "cellular response to UV-C light stimulus" EXACT [GOC:mah]
synonym: "cellular response to UV-C radiation stimulus" EXACT [GOC:mah]
synonym: "cellular response to UVC light stimulus" EXACT [GOC:mah]
synonym: "cellular response to UVC radiation stimulus" EXACT [GOC:mah]
is_a: GO:0010225 ! response to UV-C
is_a: GO:0034644 ! cellular response to UV
created_by: midori
creation_date: 2009-12-18T02:22:01Z

[Term]
id: GO:0071495
name: cellular response to endogenous stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
subset: gosubset_prok
is_a: GO:0009719 ! response to endogenous stimulus
created_by: midori
creation_date: 2009-12-18T02:25:40Z

[Term]
id: GO:0071496
name: cellular response to external stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
subset: gosubset_prok
synonym: "cellular response to environmental stimulus" EXACT [GOC:mah]
is_a: GO:0009605 ! response to external stimulus
created_by: midori
creation_date: 2009-12-18T02:36:52Z

[Term]
id: GO:0071497
name: cellular response to freezing
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius." [GOC:mah]
subset: gosubset_prok
synonym: "antifreeze activity" RELATED [GOC:mah]
synonym: "ice nucleation inhibitor activity" RELATED [GOC:mah]
is_a: GO:0050826 ! response to freezing
is_a: GO:0070417 ! cellular response to cold
created_by: midori
creation_date: 2009-12-18T02:41:02Z

[Term]
id: GO:0071498
name: cellular response to fluid shear stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface." [GOC:mah]
is_a: GO:0033554 ! cellular response to stress
is_a: GO:0034405 ! response to fluid shear stress
created_by: midori
creation_date: 2009-12-18T02:41:44Z

[Term]
id: GO:0071499
name: cellular response to laminar fluid shear stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a laminar fluid shear stress stimulus. Laminar fluid flow is the force acting on an object in a system where the fluid is moving across a solid surface in parallel layers." [GOC:mah]
is_a: GO:0034616 ! response to laminar fluid shear stress
is_a: GO:0071498 ! cellular response to fluid shear stress
created_by: midori
creation_date: 2009-12-18T02:43:02Z

[Term]
id: GO:0071500
name: cellular response to nitrosative stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions." [GOC:mah]
is_a: GO:0033554 ! cellular response to stress
is_a: GO:0051409 ! response to nitrosative stress
created_by: midori
creation_date: 2009-12-18T02:49:46Z

[Term]
id: GO:0071501
name: cellular response to sterol depletion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating deprivation of sterols. Sterols are a group of steroids characterized by the presence of one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:mah]
synonym: "cellular sterol depletion response" EXACT [GOC:mah]
is_a: GO:0006991 ! response to sterol depletion
is_a: GO:0033554 ! cellular response to stress
created_by: midori
creation_date: 2009-12-18T02:54:14Z

[Term]
id: GO:0071502
name: cellular response to temperature stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus." [GOC:mah]
subset: gosubset_prok
synonym: "cellular response to thermal stimulus" EXACT [GOC:mah]
is_a: GO:0009266 ! response to temperature stimulus
created_by: midori
creation_date: 2009-12-18T02:56:45Z

[Term]
id: GO:0071503
name: response to heparin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heparin stimulus." [GOC:mah, GOC:yaf]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: midori
creation_date: 2009-12-18T03:33:49Z

[Term]
id: GO:0071504
name: cellular response to heparin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heparin stimulus." [GOC:mah, GOC:yaf]
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:0071503 ! response to heparin
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: midori
creation_date: 2009-12-18T03:34:38Z

[Term]
id: GO:0071505
name: response to mycophenolic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mycophenolic acid stimulus." [CHEBI:168396, GOC:mah, GOC:yaf]
synonym: "response to mycophenolate" EXACT [GOC:mah]
is_a: GO:0001101 ! response to acid chemical
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: midori
creation_date: 2009-12-18T03:46:00Z

[Term]
id: GO:0071506
name: cellular response to mycophenolic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mycophenolic acid stimulus." [CHEBI:168396, GOC:mah, GOC:yaf]
synonym: "cellular response to mycophenolate" EXACT [GOC:mah]
is_a: GO:0071229 ! cellular response to acid chemical
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071505 ! response to mycophenolic acid
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: midori
creation_date: 2009-12-18T03:47:25Z

[Term]
id: GO:0071507
name: MAPK cascade involved in conjugation with cellular fusion
namespace: biological_process
def: "A MAPK cascade that contributes to conjugation with cellular fusion." [GOC:mah, GOC:vw]
synonym: "conjugation with cellular fusion, MAPKKK cascade" EXACT [GOC:mah]
synonym: "Fus3 signaling cascade" NARROW [PMID:20880736]
synonym: "MAPK signaling in response to pheromone" RELATED [PMID:20880736]
synonym: "MAPKKK cascade involved in conjugation with cellular fusion" EXACT [GOC:signaling]
synonym: "MAPKKK cascade involved in mating response" RELATED [GOC:mah]
synonym: "pheromone MAPK module" RELATED [PMID:20880736]
is_a: GO:0000165 ! MAPK cascade
is_a: GO:0032005 ! signal transduction involved in conjugation with cellular fusion
is_a: GO:0044702 ! single organism reproductive process
intersection_of: GO:0000165 ! MAPK cascade
intersection_of: part_of GO:0000747 ! conjugation with cellular fusion
relationship: part_of GO:0000747 ! conjugation with cellular fusion
relationship: part_of GO:0000750 ! pheromone-dependent signal transduction involved in conjugation with cellular fusion
created_by: midori
creation_date: 2010-01-05T01:43:47Z

[Term]
id: GO:0071508
name: activation of MAPK activity involved in conjugation with cellular fusion
namespace: biological_process
def: "Any process that initiates the activity of the inactive enzyme MAP kinase in the context of conjugation with cellular fusion." [GOC:mah]
synonym: "activation of MAPK activity involved in mating response" RELATED [GOC:mah]
synonym: "conjugation with cellular fusion, activation of MAPK activity" EXACT [GOC:mah]
is_a: GO:0000187 ! activation of MAPK activity
is_a: GO:0090028 ! positive regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0038071 ! MAP kinase activity involved in conjugation with cellular fusion
relationship: positively_regulates GO:0038071 ! MAP kinase activity involved in conjugation with cellular fusion
created_by: midori
creation_date: 2010-01-05T02:09:35Z

[Term]
id: GO:0071509
name: activation of MAPKK activity involved in conjugation with cellular fusion
namespace: biological_process
def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase in the context of conjugation with cellular fusion." [GOC:mah]
synonym: "activation of MAP kinase kinase activity during conjugation with cellular fusion" EXACT [GOC:mah]
synonym: "activation of MAPKK activity involved in mating response" RELATED [GOC:mah]
synonym: "conjugation with cellular fusion, activation of MAP kinase kinase activity" EXACT [GOC:mah]
synonym: "conjugation with cellular fusion, activation of MAPKK activity" EXACT [GOC:mah]
is_a: GO:0000186 ! activation of MAPKK activity
is_a: GO:0090028 ! positive regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0038072 ! MAP kinase kinase activity involved in conjugation with cellular fusion
relationship: positively_regulates GO:0038072 ! MAP kinase kinase activity involved in conjugation with cellular fusion
created_by: midori
creation_date: 2010-01-05T02:09:58Z

[Term]
id: GO:0071510
name: activation of MAPKKK activity involved in conjugation with cellular fusion
namespace: biological_process
def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase in the context of conjugation with cellular fusion." [GOC:mah]
synonym: "activation of MAP kinase kinase kinase activity during conjugation with cellular fusion" EXACT [GOC:mah]
synonym: "activation of MAPKKK activity involved in mating response" RELATED [GOC:mah]
synonym: "conjugation with cellular fusion, activation of MAP kinase kinase kinase activity" EXACT [GOC:mah]
synonym: "conjugation with cellular fusion, activation of MAPKKK activity" EXACT [GOC:mah]
is_a: GO:0000185 ! activation of MAPKKK activity
is_a: GO:0090028 ! positive regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0038073 ! MAP kinase kinase kinase activity involved in conjugation with cellular fusion
relationship: positively_regulates GO:0038073 ! MAP kinase kinase kinase activity involved in conjugation with cellular fusion
created_by: midori
creation_date: 2010-01-05T02:10:18Z

[Term]
id: GO:0071511
name: inactivation of MAPK activity involved in conjugation with cellular fusion
namespace: biological_process
def: "Any process that terminates the activity of the active enzyme MAP kinase in the context of conjugation with cellular fusion." [GOC:mah]
synonym: "conjugation with cellular fusion, inactivation of MAPK activity" EXACT [GOC:mah]
synonym: "conjugation with cellular fusion, termination of MAPK activity" EXACT [GOC:mah]
synonym: "inactivation of MAPK activity involved in mating response" RELATED [GOC:mah]
synonym: "termination of MAPK activity during conjugation with cellular fusion" EXACT [GOC:mah]
is_a: GO:0000188 ! inactivation of MAPK activity
is_a: GO:0090029 ! negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0038071 ! MAP kinase activity involved in conjugation with cellular fusion
relationship: negatively_regulates GO:0038071 ! MAP kinase activity involved in conjugation with cellular fusion
created_by: midori
creation_date: 2010-01-05T02:10:47Z

[Term]
id: GO:0071512
name: MAPK import into nucleus involved in conjugation with cellular fusion
namespace: biological_process
def: "The directed movement of a MAP kinase to the nucleus that occurs in the context of conjugation with cellular fusion." [GOC:mah]
synonym: "conjugation with cellular fusion, MAPK import into nucleus" EXACT [GOC:mah]
synonym: "conjugation with cellular fusion, nuclear translocation of MAPK" NARROW [GOC:mah]
synonym: "MAPK import into nucleus involved in mating response" RELATED [GOC:mah]
synonym: "nuclear translocation of MAPK involved in conjugation with cellular fusion" NARROW [GOC:mah]
synonym: "nuclear translocation of MAPK involved in mating response" RELATED [GOC:mah]
is_a: GO:0000189 ! MAPK import into nucleus
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0044763 ! single-organism cellular process
intersection_of: GO:0000189 ! MAPK import into nucleus
intersection_of: part_of GO:0000747 ! conjugation with cellular fusion
relationship: part_of GO:0000747 ! conjugation with cellular fusion
relationship: part_of GO:0071507 ! MAPK cascade involved in conjugation with cellular fusion
created_by: midori
creation_date: 2010-01-05T02:11:08Z

[Term]
id: GO:0071513
name: phosphopantothenoylcysteine decarboxylase complex
namespace: cellular_component
def: "A protein complex that catalyzes decarboxylation of 4'-phosphopantothenoylcysteine to yield 4'-phosphopantetheine; this is the third step in the biosynthesis of Coenzyme A. The complex is homotrimeric in many eukaryotes, but is a heterotrimer in Saccharomyces." [GOC:jh, PMID:19915539]
comment: See also the molecular function term 'acetolactate synthase activity ; GO:0003984'.
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:1902494 ! catalytic complex
created_by: midori
creation_date: 2010-01-05T05:23:13Z

[Term]
id: GO:0071514
name: genetic imprinting
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules by a mechanism that is mediated by DNA, is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence." [GOC:mah, GOC:vw]
synonym: "DNA imprinting" EXACT [GOC:mah]
is_a: GO:0006139 ! nucleobase-containing compound metabolic process
is_a: GO:0060255 ! regulation of macromolecule metabolic process
created_by: midori
creation_date: 2010-01-06T11:56:31Z

[Term]
id: GO:0071515
name: genetic imprinting at mating-type locus
namespace: biological_process
def: "A genetic imprinting process in which a stable single-strand DNA lesion triggers programmed gene conversion at the mating-type locus, thereby restricting mating-type interconversion to one of the two sister chromatids during DNA replication." [GOC:mah, PMID:14765111, PMID:18723894]
synonym: "mating type determination, imprinting" EXACT [GOC:vw]
is_a: GO:0006259 ! DNA metabolic process
is_a: GO:0031494 ! regulation of mating type switching
is_a: GO:0071514 ! genetic imprinting
created_by: midori
creation_date: 2010-01-06T12:58:56Z

[Term]
id: GO:0071516
name: establishment of imprinting at mating-type locus
namespace: biological_process
def: "The initial formation of a stable single-strand DNA lesion that triggers programmed gene conversion at the mating-type locus, thereby restricting mating-type interconversion to one of the two sister chromatids during DNA replication." [GOC:mah, PMID:18723894]
synonym: "mating type determination, establishment of imprinting" EXACT [GOC:vw]
is_a: GO:0006259 ! DNA metabolic process
relationship: part_of GO:0071515 ! genetic imprinting at mating-type locus
created_by: midori
creation_date: 2010-01-06T01:16:27Z

[Term]
id: GO:0071517
name: maintenance of imprinting at mating-type locus
namespace: biological_process
def: "Any process involved in preserving the structure of a stable single-strand DNA lesion that triggers programmed gene conversion at the mating-type locus, thereby restricting mating-type interconversion to one of the two sister chromatids during DNA replication." [GOC:mah, PMID:14765111, PMID:18723894]
synonym: "mating type determination, maintenance of imprinting" EXACT [GOC:mah]
is_a: GO:0006259 ! DNA metabolic process
relationship: part_of GO:0071515 ! genetic imprinting at mating-type locus
created_by: midori
creation_date: 2010-01-06T01:17:05Z

[Term]
id: GO:0071518
name: autoinducer-2 kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4,5-dihydroxy-pentane-2,3-dione + ATP = 5-phospho-4-hydroxy-pentane-2,3-dione (P-DPD) + ADP." [GOC:imk, PMID:17274596, PMID:20025244]
synonym: "4,5-dihydroxy-pentane-2,3-dione kinase activity" EXACT [CHEBI:425228, GOC:mah]
xref: MetaCyc:RXN0-5461
is_a: GO:0016301 ! kinase activity
created_by: midori
creation_date: 2010-01-06T05:08:17Z

[Term]
id: GO:0071519
name: actomyosin contractile ring actin filament bundle assembly
namespace: biological_process
def: "A process of actin filament bundle formation that occurs in the context of assembling an actomyosin contractile ring during cytokinesis." [GOC:mah, PMID:19713940]
synonym: "actin filament bundle assembly involved in actomyosin contractile ring formation" RELATED [GOC:dph, GOC:tb]
synonym: "actin filament bundle assembly involved in cytokinetic actomyosin contractile ring assembly" EXACT []
is_a: GO:0051017 ! actin filament bundle assembly
is_a: GO:2000689 ! actomyosin contractile ring assembly actin filament organization
intersection_of: GO:0051017 ! actin filament bundle assembly
intersection_of: part_of GO:0000915 ! actomyosin contractile ring assembly
relationship: part_of GO:0000915 ! actomyosin contractile ring assembly
created_by: midori
creation_date: 2010-01-06T05:27:59Z

[Term]
id: GO:0071520
name: actomyosin contractile ring assembly actin filament bundle convergence
namespace: biological_process
def: "A process of actin filament bundle distribution that occurs in the context of assembling an actomyosin contractile ring during cytokinesis, and that results in the compaction of actin filaments into a tight ring." [GOC:mah, PMID:19713940]
synonym: "actin filament bundle convergence involved in actomyosin contractile ring formation" RELATED [GOC:dph, GOC:tb]
synonym: "actin filament bundle convergence involved in cytokinetic actomyosin contractile ring assembly" EXACT []
is_a: GO:0090426 ! actin filament bundle convergence
is_a: GO:2000689 ! actomyosin contractile ring assembly actin filament organization
intersection_of: GO:0090426 ! actin filament bundle convergence
intersection_of: part_of GO:0000915 ! actomyosin contractile ring assembly
relationship: part_of GO:0000915 ! actomyosin contractile ring assembly
created_by: midori
creation_date: 2010-01-06T05:33:16Z

[Term]
id: GO:0071521
name: Cdc42 GTPase complex
namespace: cellular_component
def: "A protein complex formed by the association of the small GTPase Cdc42 with additional proteins. In Schizosaccharomyces the complex contains the Cdc42, Ras1, Scd1, Scd2, andShk1 proteins, and functions in the Ras1-Scd GTPase signalling pathway." [GOC:mah, GOC:vw, PMID:10567532, PMID:7923372, PMID:8943016]
synonym: "Ras1-Scd1-Scd2-Cdc42-Shk1 complex" EXACT [GOC:vw]
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part
created_by: midori
creation_date: 2010-01-07T01:29:12Z

[Term]
id: GO:0071522
name: ureidoglycine aminohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: ureidoglycine + H2O = S-ureidoglycolate + NH3." [MetaCyc:URUR-RXN, PMID:19935661, PMID:20038185]
subset: gosubset_prok
xref: EC:3.5.3.-
xref: MetaCyc:URUR-RXN
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
created_by: midori
creation_date: 2010-01-07T01:43:58Z

[Term]
id: GO:0071523
name: TIR domain-mediated complex assembly
namespace: biological_process
def: "A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a TIR domain interaction." [GOC:amm]
is_a: GO:0006461 ! protein complex assembly
created_by: midori
creation_date: 2010-01-07T02:11:47Z

[Term]
id: GO:0071524
name: pyrrolysine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyrrolysine, N6-{[(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-yl]carbonyl}-L-lysine." [CHEBI:21860, GOC:dh, PMID:17204561]
subset: gosubset_prok
synonym: "monomethylamine methyltransferase cofactor lysine adduct biosynthetic process" EXACT [CHEBI:21860]
synonym: "pyrrolysine anabolism" EXACT [GOC:mah]
synonym: "pyrrolysine biosynthesis" EXACT [GOC:mah]
synonym: "pyrrolysine formation" EXACT [GOC:mah]
synonym: "pyrrolysine synthesis" EXACT [GOC:mah]
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0042398 ! cellular modified amino acid biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
is_a: GO:0071525 ! pyrrolysine metabolic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
created_by: midori
creation_date: 2010-01-07T02:40:24Z

[Term]
id: GO:0071525
name: pyrrolysine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pyrrolysine, N6-{[(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-yl]carbonyl}-L-lysine." [CHEBI:21860, GOC:mah, PMID:17204561]
subset: gosubset_prok
synonym: "monomethylamine methyltransferase cofactor lysine adduct metabolic process" EXACT [CHEBI:21860]
synonym: "pyrrolysine metabolism" EXACT [GOC:mah]
is_a: GO:0006575 ! cellular modified amino acid metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process
is_a: GO:0043603 ! cellular amide metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
created_by: midori
creation_date: 2010-01-07T02:44:49Z

[Term]
id: GO:0071526
name: semaphorin-plexin signaling pathway
namespace: biological_process
def: "A series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand." [GOC:BHF, GOC:mah, GOC:vk, PMID:15239959]
synonym: "semaphorin-plexin signalling pathway" EXACT [GOC:mah]
is_a: GO:0007166 ! cell surface receptor signaling pathway
created_by: midori
creation_date: 2010-01-07T03:48:07Z

[Term]
id: GO:0071527
name: semaphorin-plexin signaling pathway involved in outflow tract morphogenesis
namespace: biological_process
def: "A series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand that contributes to outflow tract morphogenesis." [GOC:BHF, GOC:mah, GOC:vk, PMID:15239959]
synonym: "semaphorin-plexin signalling pathway involved in outflow tract morphogenesis" EXACT [GOC:mah]
is_a: GO:0061311 ! cell surface receptor signaling pathway involved in heart development
is_a: GO:0071526 ! semaphorin-plexin signaling pathway
intersection_of: GO:0071526 ! semaphorin-plexin signaling pathway
intersection_of: part_of GO:0003151 ! outflow tract morphogenesis
relationship: part_of GO:0003151 ! outflow tract morphogenesis
created_by: midori
creation_date: 2010-01-07T03:49:33Z

[Term]
id: GO:0071528
name: tRNA re-export from nucleus
namespace: biological_process
def: "The directed movement from the nucleus to the cytoplasm of a tRNA that was previously exported to the cytoplasm and then imported back into the nucleus. The processes of primary tRNA export and secondary export (re-export) can be distinguished because in organisms in which tRNA splicing occurs in the cytoplasm, the export of a mature tRNA must occur by re-export." [GOC:mcc, PMID:17475781, PMID:20032305]
synonym: "tRNA reexport from nucleus" EXACT [GOC:mcc]
is_a: GO:0006409 ! tRNA export from nucleus
created_by: midori
creation_date: 2010-01-07T04:17:05Z

[Term]
id: GO:0071529
name: cementum mineralization
namespace: biological_process
def: "The process in which calcium salts, mainly carbonated hydroxyapatite, are deposited into the initial acellular cementum." [GOC:sl, PMID:17043865]
synonym: "cementum formation" RELATED [GOC:mah]
is_a: GO:0034505 ! tooth mineralization
created_by: midori
creation_date: 2010-01-07T04:18:54Z

[Term]
id: GO:0071530
name: FHA domain-mediated complex assembly
namespace: biological_process
def: "A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by an FHA (forkhead-associated) domain interaction." [GOC:amm, InterPro:IPR000253]
synonym: "forkhead-associated domain-mediated complex assembly" EXACT [GOC:mah]
is_a: GO:0006461 ! protein complex assembly
created_by: midori
creation_date: 2010-01-08T01:57:36Z

[Term]
id: GO:0071531
name: Rel homology domain-mediated complex assembly
namespace: biological_process
def: "A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by an FHA (forkhead-associated) domain interaction." [GOC:amm, InterPro:IPR011539]
synonym: "RHD domain-mediated complex assembly" EXACT [GOC:mah]
is_a: GO:0006461 ! protein complex assembly
created_by: midori
creation_date: 2010-01-08T02:16:39Z

[Term]
id: GO:0071532
name: ankyrin repeat binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an ankyrin repeat of a protein. Ankyrin repeats are tandemly repeated modules of about 33 amino acids; each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90-degree angle, and repeats stack to form an L-shaped structure." [GOC:mah, InterPro:IPR002110]
synonym: "ANK repeat binding" EXACT [GOC:amm]
is_a: GO:0019904 ! protein domain specific binding
created_by: midori
creation_date: 2010-01-08T02:21:02Z

[Term]
id: GO:0071533
name: ankyrin repeat-mediated complex assembly
namespace: biological_process
def: "A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by an ankyrin repeat interaction." [GOC:amm, InterPro:IPR002110]
synonym: "ANK repeat-mediated complex assembly" EXACT [GOC:amm]
is_a: GO:0006461 ! protein complex assembly
created_by: midori
creation_date: 2010-01-08T02:27:56Z

[Term]
id: GO:0071534
name: zf-TRAF domain-mediated complex assembly
namespace: biological_process
def: "A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a TRAF-type zinc finger (zf-TRAF) domain interaction." [GOC:amm, InterPro:IPR001293]
synonym: "TRAF-type zinc finger domain-mediated complex assembly" EXACT [GOC:mah]
synonym: "zinc finger TRAF-type domain-mediated complex assembly" EXACT [GOC:mah]
synonym: "zinc-finger-TRAF domain-mediated complex assembly" EXACT [GOC:mah]
is_a: GO:0006461 ! protein complex assembly
created_by: midori
creation_date: 2010-01-08T02:40:50Z

[Term]
id: GO:0071535
name: RING-like zinc finger domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a RING-like zinc finger domain domain of a protein. The RING-like domain is a zinc finger domain that is related to the C3HC4 RING finger domain." [GOC:mah, InterPro:IPR014857]
is_a: GO:0019904 ! protein domain specific binding
created_by: midori
creation_date: 2010-01-08T03:10:14Z

[Term]
id: GO:0071536
name: RING-like zinc finger domain-mediated complex assembly
namespace: biological_process
def: "A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a RING-like zinc finger domain interaction." [GOC:amm, InterPro:IPR014857]
synonym: "RING-like domain-mediated complex assembly" EXACT [GOC:mah]
is_a: GO:0006461 ! protein complex assembly
created_by: midori
creation_date: 2010-01-08T03:19:47Z

[Term]
id: GO:0071537
name: C3HC4-type RING finger domain-mediated complex assembly
namespace: biological_process
def: "A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a C3HC4-type RING finger domain interaction." [GOC:amm, InterPro:IPR018957]
synonym: "zinc finger C3HC4 type domain-mediated complex assembly" EXACT [GOC:amm]
is_a: GO:0006461 ! protein complex assembly
created_by: midori
creation_date: 2010-01-08T03:42:46Z

[Term]
id: GO:0071538
name: SH2 domain-mediated complex assembly
namespace: biological_process
def: "A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by an SH2 domain interaction." [GOC:amm]
is_a: GO:0006461 ! protein complex assembly
created_by: midori
creation_date: 2010-01-08T03:46:16Z

[Term]
id: GO:0071539
name: protein localization to centrosome
namespace: biological_process
def: "A process in which a protein is transported to, or maintained at, the centrosome." [GOC:ecd]
synonym: "protein localisation to centrosome" EXACT [GOC:mah]
is_a: GO:0072698 ! protein localization to microtubule cytoskeleton
created_by: midori
creation_date: 2010-01-12T02:09:45Z

[Term]
id: GO:0071540
name: eukaryotic translation initiation factor 3 complex, eIF3e
namespace: cellular_component
def: "An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3e." [PMID:15904532, PMID:19061185]
synonym: "eIF3e-containing eukaryotic translation initiation factor 3 complex" EXACT [GOC:mah]
is_a: GO:0005852 ! eukaryotic translation initiation factor 3 complex
created_by: midori
creation_date: 2010-01-12T02:20:24Z

[Term]
id: GO:0071541
name: eukaryotic translation initiation factor 3 complex, eIF3m
namespace: cellular_component
def: "An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3m." [PMID:15904532, PMID:19061185]
synonym: "eIF3m-containing eukaryotic translation initiation factor 3 complex" EXACT [GOC:mah]
is_a: GO:0005852 ! eukaryotic translation initiation factor 3 complex
created_by: midori
creation_date: 2010-01-12T02:26:41Z

[Term]
id: GO:0071542
name: dopaminergic neuron differentiation
namespace: biological_process
def: "The process in which a neuroblast acquires the specialized structural and functional features of a dopaminergic neuron, a neuron that secretes dopamine." [GOC:rph]
is_a: GO:0030182 ! neuron differentiation
created_by: midori
creation_date: 2010-01-12T02:28:44Z

[Term]
id: GO:0071543
name: diphosphoinositol polyphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a diphosphoinositol polyphosphate, 1,2,3,4,5,6-cyclohexanehexol with one or more diphosphate groups and multiple monophosphate groups attached." [GOC:mah, PMID:12387729]
synonym: "diphosphoinositol polyphosphate metabolism" EXACT [GOC:mah]
is_a: GO:0043647 ! inositol phosphate metabolic process
created_by: midori
creation_date: 2010-01-12T05:04:00Z

[Term]
id: GO:0071544
name: diphosphoinositol polyphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a diphosphoinositol polyphosphate, 1,2,3,4,5,6-cyclohexanehexol with one or more diphosphate groups and multiple monophosphate groups attached." [GOC:mah, PMID:12387729]
synonym: "diphosphoinositol polyphosphate breakdown" EXACT [GOC:mah]
synonym: "diphosphoinositol polyphosphate catabolism" EXACT [GOC:mah]
synonym: "diphosphoinositol polyphosphate degradation" EXACT [GOC:mah]
is_a: GO:0071543 ! diphosphoinositol polyphosphate metabolic process
is_a: GO:0071545 ! inositol phosphate catabolic process
created_by: midori
creation_date: 2010-01-12T05:07:10Z

[Term]
id: GO:0071545
name: inositol phosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [CHEBI:24848, CHEBI:25448, GOC:mah]
comment: See also the biological process term 'inositol phosphate dephosphorylation ; GO:0046855'.
synonym: "inositol phosphate breakdown" EXACT [GOC:mah]
synonym: "inositol phosphate catabolism" EXACT [GOC:mah]
synonym: "inositol phosphate degradation" EXACT [GOC:mah]
synonym: "myo-inositol phosphate catabolic process" NARROW [GOC:mah]
is_a: GO:0043647 ! inositol phosphate metabolic process
is_a: GO:0046174 ! polyol catabolic process
is_a: GO:0046434 ! organophosphate catabolic process
created_by: midori
creation_date: 2010-01-12T05:07:45Z

[Term]
id: GO:0071546
name: pi-body
namespace: cellular_component
def: "A P granule that contains the PIWIL2-TDRD1 module, a set of proteins that act in the primary piRNA pathway. The pi-body corresponds to the cementing material between mitochondria found in gonocytes." [GOC:sp, PMID:20011505]
synonym: "intermitochondrial cement" EXACT [GOC:sp]
is_a: GO:0043186 ! P granule
created_by: midori
creation_date: 2010-01-12T05:44:12Z

[Term]
id: GO:0071547
name: piP-body
namespace: cellular_component
def: "A P granule that contains the PIWIL4-TDRD9 module, a set of proteins that act in the secondary piRNA pathway." [GOC:sp, PMID:20011505]
is_a: GO:0043186 ! P granule
created_by: midori
creation_date: 2010-01-12T05:47:47Z

[Term]
id: GO:0071548
name: response to dexamethasone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus." [GOC:mah, GOC:yaf]
synonym: "response to dexamethasone stimulus" EXACT [GOC:dos]
is_a: GO:0051384 ! response to glucocorticoid
is_a: GO:0097305 ! response to alcohol
is_a: GO:1901654 ! response to ketone
created_by: midori
creation_date: 2010-01-13T01:24:40Z

[Term]
id: GO:0071549
name: cellular response to dexamethasone stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus." [GOC:mah, GOC:yaf]
is_a: GO:0071385 ! cellular response to glucocorticoid stimulus
is_a: GO:0071548 ! response to dexamethasone
is_a: GO:0097306 ! cellular response to alcohol
is_a: GO:1901655 ! cellular response to ketone
created_by: midori
creation_date: 2010-01-13T01:24:49Z

[Term]
id: GO:0071550
name: death-inducing signaling complex assembly
namespace: biological_process
def: "A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a death domain (DD) interaction, as part of the extrinsic apoptotic signaling pathway." [GOC:amm, GOC:mtg_apoptosis, InterPro:IPR000488]
synonym: "DD-mediated complex assembly" EXACT [GOC:mah]
synonym: "death domain-mediated complex assembly" EXACT []
synonym: "death domain-mediated complex assembly involved in extrinsic apoptotic pathway" EXACT []
synonym: "death-inducing signaling complex formation" EXACT []
synonym: "death-inducing signalling complex assembly" EXACT []
synonym: "DISC assembly" EXACT []
synonym: "DISC formation" EXACT []
is_a: GO:0006461 ! protein complex assembly
relationship: part_of GO:0097191 ! extrinsic apoptotic signaling pathway
created_by: midori
creation_date: 2010-01-13T02:48:38Z

[Term]
id: GO:0071551
name: RIP homotypic interaction motif binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a RIP homotypic interaction motif (RHIM) of a protein. The RHIM is a 16-amino-acid motif found in some members, including RIP3, of a family of related kinases." [GOC:mah, PMID:11734559]
synonym: "RHIM binding" EXACT [GOC:mah]
is_a: GO:0019904 ! protein domain specific binding
created_by: midori
creation_date: 2010-01-13T03:03:51Z

[Term]
id: GO:0071552
name: RIP homotypic interaction motif-mediated complex assembly
namespace: biological_process
def: "A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a RIP homotypic interaction motif (RHIM) interaction." [GOC:amm, PMID:11734559]
synonym: "RHIM-mediated complex assembly" EXACT [GOC:mah]
is_a: GO:0006461 ! protein complex assembly
created_by: midori
creation_date: 2010-01-13T03:08:30Z

[Term]
id: GO:0071553
name: G-protein coupled pyrimidinergic nucleotide receptor activity
namespace: molecular_function
def: "Combining with a pyrimidine nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:sl, PMID:10736418, PMID:12369950, PMID:15796906]
synonym: "G protein coupled pyrimidinergic nucleotide receptor activity" EXACT []
synonym: "G-protein-coupled pyrimidinergic nucleotide receptor activity" EXACT []
synonym: "pyrimidinergic nucleotide receptor activity, G protein coupled" EXACT []
synonym: "pyrimidinergic nucleotide receptor activity, G-protein coupled" EXACT [GOC:bf]
is_a: GO:0001608 ! G-protein coupled nucleotide receptor activity
is_a: GO:0016502 ! nucleotide receptor activity
relationship: has_part GO:0019103 ! pyrimidine nucleotide binding
created_by: midori
creation_date: 2010-01-13T03:13:22Z

[Term]
id: GO:0071554
name: cell wall organization or biogenesis
namespace: biological_process
alt_id: GO:0070882
def: "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cell wall." [GOC:mah]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "cell wall organisation or biogenesis" EXACT [GOC:mah]
synonym: "cell wall organization or biogenesis at cellular level" EXACT [GOC:mah]
synonym: "cellular cell wall organisation or biogenesis" EXACT [GOC:mah]
synonym: "cellular cell wall organization or biogenesis" EXACT []
is_a: GO:0009987 ! cellular process
created_by: midori
creation_date: 2010-01-13T03:19:38Z

[Term]
id: GO:0071555
name: cell wall organization
namespace: biological_process
alt_id: GO:0007047
alt_id: GO:0044234
def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:mah]
subset: goslim_candida
subset: goslim_pir
subset: gosubset_prok
synonym: "cell wall organisation" EXACT [GOC:curators]
synonym: "cell wall organisation in other organism" EXACT [GOC:mah]
synonym: "cell wall organization and biogenesis" RELATED [GOC:mah]
synonym: "cell wall organization at cellular level" EXACT [GOC:mah]
synonym: "cell wall organization in other organism" EXACT []
synonym: "cellular cell wall organisation" EXACT [GOC:curators]
synonym: "cellular cell wall organization" EXACT []
is_a: GO:0045229 ! external encapsulating structure organization
is_a: GO:0071554 ! cell wall organization or biogenesis
created_by: midori
creation_date: 2010-01-13T03:33:07Z

[Term]
id: GO:0071556
name: integral component of lumenal side of endoplasmic reticulum membrane
namespace: cellular_component
def: "The component of the endoplasmic reticulum membrane consisting of the gene products that penetrate only the lumenal side of the membrane." [GOC:dos, GOC:mah]
synonym: "integral to ER membrane, lumenal side" EXACT [GOC:vw]
synonym: "integral to lumenal leaflet of endoplasmic reticulum membrane" EXACT [GOC:ab]
synonym: "integral to lumenal side of endoplasmic reticulum membrane" NARROW []
synonym: "integral to lumenal side of ER membrane" EXACT [GOC:mah]
is_a: GO:0030176 ! integral component of endoplasmic reticulum membrane
intersection_of: GO:0016021 ! integral component of membrane
intersection_of: part_of GO:0098553 ! lumenal side of endoplasmic reticulum membrane
relationship: part_of GO:0098553 ! lumenal side of endoplasmic reticulum membrane
created_by: midori
creation_date: 2010-01-15T10:56:58Z

[Term]
id: GO:0071557
name: histone H3-K27 demethylation
namespace: biological_process
def: "The modification of histone H3 by the removal of a methyl group from lysine at position 27 of the histone." [GOC:sp, PMID:20023638]
synonym: "H3K27 demethylation" RELATED [GOC:mah]
is_a: GO:0070076 ! histone lysine demethylation
created_by: midori
creation_date: 2010-01-15T10:59:50Z

[Term]
id: GO:0071558
name: histone demethylase activity (H3-K27 specific)
namespace: molecular_function
def: "Catalysis of the removal of a methyl group from lysine at position 27 of the histone H3 protein." [GOC:sp, PMID:20622853]
is_a: GO:0032452 ! histone demethylase activity
relationship: part_of GO:0071557 ! histone H3-K27 demethylation
created_by: midori
creation_date: 2010-01-15T11:33:17Z

[Term]
id: GO:0071559
name: response to transforming growth factor beta
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus." [GOC:mah]
synonym: "response to TGF-beta stimulus" EXACT [GOC:mah]
synonym: "response to TGFbeta stimulus" EXACT [GOC:mah]
synonym: "response to transforming growth factor beta stimulus" EXACT [GOC:dos]
is_a: GO:0009719 ! response to endogenous stimulus
is_a: GO:0070848 ! response to growth factor
created_by: midori
creation_date: 2010-01-20T11:49:59Z

[Term]
id: GO:0071560
name: cellular response to transforming growth factor beta stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus." [GOC:ecd, PMID:15451575]
synonym: "cellular response to TGF-beta stimulus" EXACT [GOC:mah]
synonym: "cellular response to TGFbeta stimulus" EXACT [GOC:mah]
is_a: GO:0071363 ! cellular response to growth factor stimulus
is_a: GO:0071495 ! cellular response to endogenous stimulus
is_a: GO:0071559 ! response to transforming growth factor beta
created_by: midori
creation_date: 2010-01-20T11:51:18Z

[Term]
id: GO:0071561
name: nucleus-vacuole junction
namespace: cellular_component
def: "An organelle membrane contact site formed between the vacuole membrane and the outer nuclear membrane. In S. cerevisiae these contacts are mediated through direct physical interaction between Vac8p and Nvj1p." [GOC:jp, PMID:16709156, PMID:16806880]
synonym: "nucleus-vacuole membrane contact site" EXACT [GOC:mah]
synonym: "NV junction" EXACT [GOC:jp, PMID:16709156]
synonym: "NVJ" EXACT [GOC:mah, PMID:16806880]
is_a: GO:0044232 ! organelle membrane contact site
created_by: midori
creation_date: 2010-01-20T02:09:42Z

[Term]
id: GO:0071562
name: nucleus-vacuole junction assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a nucleus-vacuole junction, which are membrane contact sites formed between the vacuole membrane and the outer nuclear membrane. In S. cerevisiae these contacts are mediated through direct physical interaction between Vac8p and Nvj1p." [GOC:jp, PMID:16709156]
synonym: "nucleus-vacuole junction formation" EXACT [GOC:jp]
synonym: "NV junction assembly" EXACT [GOC:jp, PMID:16709156]
synonym: "NV junction formation" EXACT [GOC:jp, PMID:16709156]
synonym: "NVJ assembly" EXACT [GOC:mah, PMID:16806880]
synonym: "NVJ formation" EXACT [GOC:mah, PMID:16806880]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0022614 ! membrane to membrane docking
relationship: part_of GO:0034727 ! piecemeal microautophagy of nucleus
created_by: midori
creation_date: 2010-01-20T02:16:36Z

[Term]
id: GO:0071563
name: Myo2p-Vac17p-Vac8p transport complex
namespace: cellular_component
def: "A protein complex that is involved in transport of vacuoles to a newly formed daughter cell. In yeast, this complex is composed of Myo2p, Vac17p, and Vac8p." [GOC:jp, PMID:12594460]
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part
created_by: midori
creation_date: 2010-01-20T03:03:24Z

[Term]
id: GO:0071564
name: npBAF complex
namespace: cellular_component
def: "A SWI/SNF-type complex that is found in neural stem or progenitor cells, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A genes. The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells." [GOC:mah, GOC:ss, PMID:17640523]
is_a: GO:0090544 ! BAF-type complex
created_by: midori
creation_date: 2010-01-20T03:33:42Z

[Term]
id: GO:0071565
name: nBAF complex
namespace: cellular_component
def: "A SWI/SNF-type complex that is found in post-mitotic neurons, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B genes. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth." [GOC:mah, GOC:ss, PMID:17640523]
is_a: GO:0090544 ! BAF-type complex
is_a: GO:0097458 ! neuron part
created_by: midori
creation_date: 2010-01-20T03:41:19Z

[Term]
id: GO:0071566
name: UFM1 activating enzyme activity
namespace: molecular_function
def: "Catalysis of the activation of the small ubiquitin-related modifier UFM1, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:sp, PMID:20018847]
is_a: GO:0008641 ! small protein activating enzyme activity
created_by: midori
creation_date: 2010-01-20T04:06:05Z

[Term]
id: GO:0071567
name: UFM1 hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of UFM1, a small ubiquitin-related modifier, from previously modified substrates." [GOC:sp, PMID:20018847]
is_a: GO:0019783 ! ubiquitin-like protein-specific protease activity
created_by: midori
creation_date: 2010-01-20T04:08:34Z

[Term]
id: GO:0071568
name: UFM1 transferase activity
namespace: molecular_function
def: "Catalysis of the transfer of UFM1 from one protein to another via the reaction X-UFM1 + Y --> Y-UFM1 + X, where both X-UFM1 and Y-UFM1 are covalent linkages." [GOC:sp, PMID:20018847]
is_a: GO:0019787 ! ubiquitin-like protein transferase activity
created_by: midori
creation_date: 2010-01-20T04:10:11Z

[Term]
id: GO:0071569
name: protein ufmylation
namespace: biological_process
def: "Covalent attachment of the ubiquitin-like protein UFM1 to another protein." [GOC:vw, PMID:20018847]
is_a: GO:0032446 ! protein modification by small protein conjugation
created_by: midori
creation_date: 2010-01-20T04:12:01Z

[Term]
id: GO:0071570
name: cement gland development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cement gland over time, from its formation to the mature structure. The cement gland is a simple mucus-secreting organ positioned at the anterior of amphibious embryos. The cement gland attaches the newly hatched embryo to a support before the hatchling can swim well or feed." [GOC:bf]
is_a: GO:0048732 ! gland development
created_by: midori
creation_date: 2010-01-20T04:31:04Z

[Term]
id: GO:0071571
name: LRR domain-mediated complex assembly
namespace: biological_process
def: "A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by an LRR (leucine-rich repeat) domain interaction." [GOC:amm, InterPro:IPR001611]
synonym: "leucine-rich repeat domain-mediated complex assembly" EXACT [GOC:mah]
is_a: GO:0006461 ! protein complex assembly
created_by: midori
creation_date: 2010-01-20T04:33:49Z

[Term]
id: GO:0071572
name: histone H3-K56 deacetylation
namespace: biological_process
def: "The modification of histone H3 by the removal of an acetyl group from lysine at position 56 of the histone." [GOC:mah]
is_a: GO:0070932 ! histone H3 deacetylation
created_by: midori
creation_date: 2010-01-20T04:50:03Z

[Term]
id: GO:0071573
name: telosome assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a telosome. A telosome is a nuclear telomere cap complex that is formed by the association of telomeric ssDNA- and dsDNA-binding proteins with telomeric DNA, and is involved in telomere protection and recruitment of telomerase." [GOC:mah, GOC:vw]
synonym: "Pot1 complex assembly" EXACT [GOC:mah]
synonym: "Pot1-Tpz1 complex assembly" EXACT [GOC:mah]
synonym: "shelterin complex formation" EXACT [GOC:mah]
is_a: GO:0065004 ! protein-DNA complex assembly
created_by: midori
creation_date: 2010-01-26T01:45:20Z

[Term]
id: GO:0071574
name: protein localization to medial cortex
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, the medial cortex." [GOC:mah]
synonym: "protein localisation to medial cortex" EXACT [GOC:mah]
is_a: GO:0072697 ! protein localization to cell cortex
is_a: GO:0072741 ! protein localization to cell division site
created_by: midori
creation_date: 2010-01-26T05:17:50Z

[Term]
id: GO:0071575
name: integral component of external side of plasma membrane
namespace: cellular_component
def: "The component of the plasma membrane consisting of the gene products that penetrate only the external side of the membrane." [GOC:dos, GOC:mah]
synonym: "integral to external leaflet of plasma membrane" EXACT [GOC:ab]
synonym: "integral to external side of plasma membrane" NARROW []
is_a: GO:0005887 ! integral component of plasma membrane
is_a: GO:0031233 ! intrinsic component of external side of plasma membrane
intersection_of: GO:0016021 ! integral component of membrane
intersection_of: part_of GO:0009897 ! external side of plasma membrane
relationship: part_of GO:0009897 ! external side of plasma membrane
created_by: midori
creation_date: 2010-01-26T05:20:28Z

[Term]
id: GO:0071576
name: tetrahydrodictyopterin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with tetrahydrodictyopterin, the pterin 2-amino-6-[(1R,2R)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydropteridin-4(3H)-one." [CHEBI:52447, GOC:mah, GOC:vw]
synonym: "D-threo-tetrahydrobiopterin" EXACT [GOC:mah]
synonym: "DH4 binding" EXACT [GOC:mah]
is_a: GO:0034617 ! tetrahydrobiopterin binding
created_by: midori
creation_date: 2010-01-26T05:24:59Z

[Term]
id: GO:0071577
name: zinc II ion transmembrane transport
namespace: biological_process
def: "A process in which a zinc II ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:BHF, GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "zinc ion membrane transport" EXACT []
synonym: "zinc transmembrane transport" EXACT [GOC:mah]
is_a: GO:0006829 ! zinc II ion transport
is_a: GO:0098662 ! inorganic cation transmembrane transport
created_by: midori
creation_date: 2010-01-28T02:17:12Z

[Term]
id: GO:0071578
name: zinc II ion transmembrane import
namespace: biological_process
def: "The directed movement of zinc II ions across a membrane into a cell or organelle." [GOC:BHF, GOC:mah]
synonym: "zinc import" EXACT [GOC:mah]
synonym: "zinc uptake" EXACT [GOC:mah]
is_a: GO:0071577 ! zinc II ion transmembrane transport
created_by: midori
creation_date: 2010-01-28T02:22:02Z

[Term]
id: GO:0071579
name: regulation of zinc ion transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of zinc ions (Zn2+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:BHF, GOC:mah]
is_a: GO:0010959 ! regulation of metal ion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006829 ! zinc II ion transport
relationship: regulates GO:0006829 ! zinc II ion transport
created_by: midori
creation_date: 2010-01-28T03:02:15Z

[Term]
id: GO:0071580
name: regulation of zinc ion transmembrane transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of zinc ions (Zn2+) from one side of a membrane to the other." [GOC:BHF, GOC:mah]
synonym: "regulation of zinc ion membrane transport" EXACT []
is_a: GO:0071579 ! regulation of zinc ion transport
is_a: GO:1904062 ! regulation of cation transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071577 ! zinc II ion transmembrane transport
relationship: regulates GO:0071577 ! zinc II ion transmembrane transport
created_by: midori
creation_date: 2010-01-28T03:05:53Z

[Term]
id: GO:0071581
name: regulation of zinc ion transmembrane import
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of zinc ions (Zn2+) from one side of a membrane to the other." [GOC:BHF, GOC:mah]
is_a: GO:0071580 ! regulation of zinc ion transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071578 ! zinc II ion transmembrane import
relationship: regulates GO:0071578 ! zinc II ion transmembrane import
created_by: midori
creation_date: 2010-01-28T03:09:19Z

[Term]
id: GO:0071582
name: negative regulation of zinc ion transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of zinc ions (Zn2+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:BHF, GOC:mah]
is_a: GO:0043271 ! negative regulation of ion transport
is_a: GO:0071579 ! regulation of zinc ion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006829 ! zinc II ion transport
relationship: negatively_regulates GO:0006829 ! zinc II ion transport
created_by: midori
creation_date: 2010-01-28T03:14:25Z

[Term]
id: GO:0071583
name: negative regulation of zinc ion transmembrane transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of zinc ions (Zn2+) from one side of a membrane to the other." [GOC:BHF, GOC:mah]
synonym: "negative regulation of zinc ion membrane transport" EXACT []
is_a: GO:0071580 ! regulation of zinc ion transmembrane transport
is_a: GO:0071582 ! negative regulation of zinc ion transport
is_a: GO:1904063 ! negative regulation of cation transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071577 ! zinc II ion transmembrane transport
relationship: negatively_regulates GO:0071577 ! zinc II ion transmembrane transport
created_by: midori
creation_date: 2010-01-28T03:15:54Z

[Term]
id: GO:0071584
name: negative regulation of zinc ion transmembrane import
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of zinc ions (Zn2+) from one side of a membrane to the other." [GOC:BHF, GOC:mah]
is_a: GO:0071581 ! regulation of zinc ion transmembrane import
is_a: GO:0071583 ! negative regulation of zinc ion transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071578 ! zinc II ion transmembrane import
relationship: negatively_regulates GO:0071578 ! zinc II ion transmembrane import
created_by: midori
creation_date: 2010-01-28T03:17:21Z

[Term]
id: GO:0071585
name: detoxification of cadmium ion
namespace: biological_process
def: "Any process that reduces or removes the toxicity of cadmium ion. These may include transport of cadmium away from sensitive areas and to compartments or complexes whose purpose is sequestration of cadmium ion." [GOC:BHF, GOC:kmv, PMID:16741752]
is_a: GO:0061687 ! detoxification of inorganic compound
relationship: part_of GO:1990170 ! stress response to cadmium ion
created_by: midori
creation_date: 2010-01-28T03:38:48Z

[Term]
id: GO:0071586
name: CAAX-box protein processing
namespace: biological_process
def: "The second process in a series of specific posttranslational modifications to the CAAX box region of CAAX box proteins, in which the last three amino acids of the protein (AAX) are removed by proteolysis." [GOC:mah]
is_a: GO:0016485 ! protein processing
relationship: part_of GO:0080120 ! CAAX-box protein maturation
created_by: midori
creation_date: 2010-01-28T04:42:45Z

[Term]
id: GO:0071587
name: CAAX-box protein modification
namespace: biological_process
def: "The covalent alteration of one or more amino acid residues within the CAAX box region of CAAX box proteins." [GOC:mah]
is_a: GO:0043687 ! post-translational protein modification
relationship: part_of GO:0080120 ! CAAX-box protein maturation
created_by: midori
creation_date: 2010-01-28T04:48:56Z

[Term]
id: GO:0071588
name: hydrogen peroxide mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals mediated by the detection of hydrogen peroxide (H2O2)." [GOC:mah, PMID:17043891]
synonym: "H2O2 mediated signaling pathway" EXACT [GOC:mah]
synonym: "hydrogen peroxide mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0007165 ! signal transduction
created_by: midori
creation_date: 2010-01-29T11:18:58Z

[Term]
id: GO:0071589
name: pyridine nucleoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any pyridine nucleoside, one of a family of organic molecules consisting of a pyridine base covalently bonded to a sugar, usually ribose." [CHEBI:47896, GOC:mah]
subset: gosubset_prok
synonym: "pyridine nucleoside anabolism" EXACT [GOC:mah]
synonym: "pyridine nucleoside biosynthesis" EXACT [GOC:mah]
synonym: "pyridine nucleoside formation" EXACT [GOC:mah]
synonym: "pyridine nucleoside synthesis" EXACT [GOC:mah]
is_a: GO:0009163 ! nucleoside biosynthetic process
is_a: GO:0070637 ! pyridine nucleoside metabolic process
is_a: GO:0072525 ! pyridine-containing compound biosynthetic process
created_by: midori
creation_date: 2010-01-29T11:35:30Z

[Term]
id: GO:0071590
name: nicotinamide riboside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nicotinamide riboside, the product of the formation of a glycosidic bond between ribose and nicotinamide." [CHEBI:15927, GOC:mah, PMID:19846558]
synonym: "N-ribosylnicotinamide biosynthetic process" EXACT [CHEBI:15927]
synonym: "nicotinamide riboside anabolism" EXACT [GOC:mah]
synonym: "nicotinamide riboside biosynthesis" EXACT [GOC:mah]
synonym: "nicotinamide riboside formation" EXACT [GOC:mah]
synonym: "nicotinamide riboside synthesis" EXACT [GOC:mah]
is_a: GO:0046495 ! nicotinamide riboside metabolic process
is_a: GO:0071589 ! pyridine nucleoside biosynthetic process
created_by: midori
creation_date: 2010-01-29T11:39:27Z

[Term]
id: GO:0071591
name: nicotinic acid riboside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nicotinic acid riboside, the product of the formation of a glycosidic bond between ribose and nicotinic acid." [CHEBI:27748, GOC:mah, PMID:19846558]
synonym: "D-ribosylnicotinic acid metabolic process" EXACT [CHEBI:27748]
synonym: "nicotinic acid riboside metabolism" EXACT [GOC:mah]
is_a: GO:0070637 ! pyridine nucleoside metabolic process
created_by: midori
creation_date: 2010-01-29T11:50:42Z

[Term]
id: GO:0071592
name: nicotinic acid riboside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nicotinic acid riboside, the product of the formation of a glycosidic bond between ribose and nicotinic acid." [CHEBI:27748, GOC:mah, PMID:19846558]
synonym: "D-ribosylnicotinic acid biosynthetic process" EXACT [CHEBI:27748]
synonym: "nicotinic acid riboside anabolism" EXACT [GOC:mah]
synonym: "nicotinic acid riboside biosynthesis" EXACT [GOC:mah]
synonym: "nicotinic acid riboside formation" EXACT [GOC:mah]
synonym: "nicotinic acid riboside synthesis" EXACT [GOC:mah]
is_a: GO:0071589 ! pyridine nucleoside biosynthetic process
is_a: GO:0071591 ! nicotinic acid riboside metabolic process
created_by: midori
creation_date: 2010-01-29T12:01:25Z

[Term]
id: GO:0071593
name: lymphocyte aggregation
namespace: biological_process
def: "The adhesion of one lymphocyte to one or more other lymphocytes via adhesion molecules." [GOC:sl]
is_a: GO:0070486 ! leukocyte aggregation
created_by: midori
creation_date: 2010-01-29T01:37:30Z

[Term]
id: GO:0071594
name: thymocyte aggregation
namespace: biological_process
def: "The adhesion of one thymocyte (an immature T cell) to one or more other thymocytes via adhesion molecules." [GOC:sl, PMID:1382990]
synonym: "immature T cell aggregation" BROAD [CL:0000893, GOC:sl]
synonym: "immature T-cell aggregation" BROAD [CL:0000893, GOC:mah]
synonym: "immature T-lymphocyte aggregation" EXACT [CL:0000893, GOC:mah]
synonym: "T cell precursor aggregation" EXACT [GOC:sl]
synonym: "thymic lymphocyte aggregation" EXACT [GOC:sl]
is_a: GO:0070489 ! T cell aggregation
created_by: midori
creation_date: 2010-01-29T01:38:49Z

[Term]
id: GO:0071595
name: Nem1-Spo7 phosphatase complex
namespace: cellular_component
def: "A protein serine/threonine phosphatase complex that is involved in nuclear envelope organization, and contains proteins known in budding yeast as Nem1p and Spo7p." [GOC:mah, PMID:9822591]
is_a: GO:0008287 ! protein serine/threonine phosphatase complex
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0042175 ! nuclear outer membrane-endoplasmic reticulum membrane network
created_by: midori
creation_date: 2010-01-29T02:17:29Z

[Term]
id: GO:0071596
name: ubiquitin-dependent protein catabolic process via the N-end rule pathway
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the N-end rule pathway. In the N-end rule pathway, destabilizing N-terminal residues (N-degrons) in substrates are recognized by E3 ligases (N-recognins), whereupon the substrates are linked to ubiquitin and then delivered to the proteasome for degradation." [GOC:mah, GOC:rb, PMID:19246002, PMID:9112437]
synonym: "ubiquitin-dependent protein breakdown via the N-end rule pathway" EXACT [GOC:mah]
synonym: "ubiquitin-dependent protein catabolism via the N-end rule pathway" EXACT [GOC:mah]
synonym: "ubiquitin-dependent protein degradation via the N-end rule pathway" EXACT [GOC:mah]
is_a: GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process
created_by: midori
creation_date: 2010-01-29T03:01:09Z

[Term]
id: GO:0071597
name: cellular birth scar
namespace: cellular_component
def: "Crater-like ring of chitinous scar tissue located on the surface of the daughter cell, in budding fungi, at the site of separation from the mother cell. It is formed after the newly emerged daughter cell separates, thereby marking the site of cytokinesis and septation." [GOC:mcc, PMID:16672383, PMID:7730409]
is_a: GO:0044426 ! cell wall part
relationship: part_of GO:0009277 ! fungal-type cell wall
created_by: midori
creation_date: 2010-02-02T02:42:44Z

[Term]
id: GO:0071598
name: neuronal ribonucleoprotein granule
namespace: cellular_component
def: "A ribonucleoprotein complex that is found in the cytoplasm of axons and dendrites, and transports translationally silenced mRNAs to dendritic synapses, where they are released and translated in response to specific exogenous stimuli." [GOC:BHF, GOC:go_curators, GOC:mah, PMID:19015237, PMID:20368989]
synonym: "neuronal RNA granule" NARROW []
synonym: "neuronal RNP granule" EXACT []
is_a: GO:0036464 ! cytoplasmic ribonucleoprotein granule
is_a: GO:0044463 ! cell projection part
is_a: GO:0097458 ! neuron part
relationship: part_of GO:0032838 ! cell projection cytoplasm
relationship: part_of GO:0043005 ! neuron projection
created_by: midori
creation_date: 2010-02-04T04:01:57Z

[Term]
id: GO:0071599
name: otic vesicle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the otic vesicle over time, from its formation to the mature structure. The otic vesicle is a transient embryonic structure formed during development of the vertebrate inner ear." [GOC:mah]
is_a: GO:0007423 ! sensory organ development
is_a: GO:0048839 ! inner ear development
is_a: GO:0060429 ! epithelium development
created_by: midori
creation_date: 2010-02-04T04:07:17Z

[Term]
id: GO:0071600
name: otic vesicle morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the otic vesicle are generated and organized. The otic vesicle is a transient embryonic structure formed during development of the vertebrate inner ear." [GOC:mah]
is_a: GO:0002009 ! morphogenesis of an epithelium
is_a: GO:0042472 ! inner ear morphogenesis
is_a: GO:0048562 ! embryonic organ morphogenesis
relationship: part_of GO:0071599 ! otic vesicle development
created_by: midori
creation_date: 2010-02-04T04:07:27Z

[Term]
id: GO:0071601
name: sphere organelle
namespace: cellular_component
def: "A nuclear body that is found in the germinal vesicles of amphibian oocytes, and consist of three major parts: a remarkably spherical body about 5-10 pm in diameter, smaller spherical or nearly spherical granules on the surface, and inclusions of various sizes that strongly resemble the surface granules. The parts of the sphere organelle have distinct compositions, including splicing snRNAs and proteins." [PMID:7758244, PMID:8349728]
is_a: GO:0016604 ! nuclear body
created_by: midori
creation_date: 2010-02-04T04:26:41Z

[Term]
id: GO:0071602
name: phytosphingosine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phytosphingosine, (2S,3S,4R)-2-aminooctadecane-1,3,4-triol." [CHEBI:46961, GOC:mah]
synonym: "phytosphingosine anabolism" EXACT [GOC:mah]
synonym: "phytosphingosine biosynthesis" EXACT [GOC:mah]
synonym: "phytosphingosine formation" EXACT [GOC:mah]
synonym: "phytosphingosine synthesis" EXACT [GOC:mah]
is_a: GO:0006671 ! phytosphingosine metabolic process
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process
is_a: GO:0046173 ! polyol biosynthetic process
is_a: GO:0046520 ! sphingoid biosynthetic process
created_by: midori
creation_date: 2010-02-04T05:15:59Z

[Term]
id: GO:0071603
name: endothelial cell-cell adhesion
namespace: biological_process
def: "The attachment of an endothelial cell to another endothelial cell via adhesion molecules." [GOC:BHF]
is_a: GO:0090136 ! epithelial cell-cell adhesion
created_by: midori
creation_date: 2010-02-04T05:21:30Z

[Term]
id: GO:0071604
name: transforming growth factor beta production
namespace: biological_process
def: "The appearance of any member of the transforming growth factor-beta family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Transforming growth factor-beta family members include TGF-B1, TGF-B2, and TGF-B3." [GOC:add, GOC:rv]
synonym: "TGF-B production" EXACT [GOC:mah]
synonym: "TGF-beta production" EXACT [GOC:mah]
synonym: "TGFB production" EXACT [GOC:mah]
synonym: "TGFb production" EXACT [GOC:rv]
synonym: "transforming growth factor-beta production" EXACT [GOC:bf]
is_a: GO:0001816 ! cytokine production
created_by: midori
creation_date: 2010-02-05T03:56:57Z

[Term]
id: GO:0071605
name: monocyte chemotactic protein-1 production
namespace: biological_process
def: "The appearance of monocyte chemotactic protein-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv]
synonym: "CCL2 production" EXACT [GOC:add, GOC:rv]
synonym: "MCP-1 production" EXACT [GOC:add, GOC:rv]
is_a: GO:0032602 ! chemokine production
created_by: midori
creation_date: 2010-02-05T04:09:53Z

[Term]
id: GO:0071606
name: chemokine (C-C motif) ligand 4 production
namespace: biological_process
def: "The appearance of chemokine (C-C motif) ligand 4 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv]
synonym: "CCL4 production" EXACT [GOC:add, GOC:rv]
synonym: "macrophage inflammatory protein production" BROAD [GOC:add, GOC:rv]
synonym: "MIP-1b production" EXACT [GOC:add, GOC:rv]
is_a: GO:0032602 ! chemokine production
created_by: midori
creation_date: 2010-02-05T04:16:42Z

[Term]
id: GO:0071607
name: macrophage inflammatory protein-1 gamma production
namespace: biological_process
def: "The appearance of macrophage inflammatory protein-1 gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv]
synonym: "CCL9 production" EXACT [GOC:add, GOC:rv]
synonym: "chemokine (C-C motif) ligand 9 production" EXACT [GOC:add, GOC:rv]
synonym: "MIP-1g production" EXACT [GOC:add, GOC:rv]
is_a: GO:0032602 ! chemokine production
created_by: midori
creation_date: 2010-02-05T04:19:52Z

[Term]
id: GO:0071608
name: macrophage inflammatory protein-1 alpha production
namespace: biological_process
def: "The appearance of macrophage inflammatory protein 1 alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv]
synonym: "CCL3 production" EXACT [GOC:add, GOC:rv]
synonym: "chemokine (C-C motif) ligand 3 production" EXACT [GOC:add, GOC:rv]
synonym: "macrophage inflammatory protein production" BROAD [GOC:add, GOC:rv]
synonym: "MIP-1a production" EXACT [GOC:add, GOC:rv]
is_a: GO:0032602 ! chemokine production
created_by: midori
creation_date: 2010-02-05T04:24:17Z

[Term]
id: GO:0071609
name: chemokine (C-C motif) ligand 5 production
namespace: biological_process
def: "The appearance of chemokine (C-C motif) ligand 5 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv]
synonym: "CCL5 production" EXACT [GOC:add, GOC:rv]
synonym: "RANTES production" EXACT [GOC:bf]
synonym: "Regulated upon Activation, Normal T-cell Expressed, and Secreted production" EXACT [GOC:add, GOC:rv]
is_a: GO:0032602 ! chemokine production
created_by: midori
creation_date: 2010-02-05T04:32:35Z

[Term]
id: GO:0071610
name: chemokine (C-C motif) ligand 1 production
namespace: biological_process
def: "The appearance of chemokine (C-C motif) ligand 1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv]
synonym: "CCL1 production" EXACT [GOC:add, GOC:rv]
synonym: "T cell activation 3 production" EXACT [GOC:add, GOC:rv]
synonym: "TCA-3 production" EXACT [GOC:add, GOC:rv]
is_a: GO:0032602 ! chemokine production
created_by: midori
creation_date: 2010-02-05T04:35:00Z

[Term]
id: GO:0071611
name: granulocyte colony-stimulating factor production
namespace: biological_process
def: "The appearance of granulocyte colony-stimulating factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv]
synonym: "colony stimulating factor 3 (granulocyte) production" EXACT [GOC:add]
synonym: "CSF3 production" EXACT [GOC:add]
synonym: "filgrastim production" EXACT [GOC:add]
synonym: "G-CSF production" EXACT [GOC:add]
synonym: "granulocyte colony stimulating factor production" EXACT []
synonym: "lenograstim production" EXACT [GOC:add]
synonym: "pluripoietin production" EXACT [GOC:add]
is_a: GO:0001816 ! cytokine production
created_by: midori
creation_date: 2010-02-05T04:38:11Z

[Term]
id: GO:0071612
name: IP-10 production
namespace: biological_process
def: "The appearance of IP-10 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv]
synonym: "chemokine (C-C motif) ligand 10 production" EXACT [GOC:add, GOC:rv]
synonym: "CXCL10 production" EXACT [GOC:add, GOC:rv]
is_a: GO:0032602 ! chemokine production
created_by: midori
creation_date: 2010-02-05T04:43:56Z

[Term]
id: GO:0071613
name: granzyme B production
namespace: biological_process
def: "The appearance of granzyme B due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv]
is_a: GO:0002440 ! production of molecular mediator of immune response
created_by: midori
creation_date: 2010-02-05T04:47:15Z

[Term]
id: GO:0071614
name: linoleic acid epoxygenase activity
namespace: molecular_function
def: "Catalysis of an NADPH- and oxygen-dependent reaction that converts linoleic acid to a cis-epoxyoctadecenoic acid." [GOC:BHF, PMID:11042099]
synonym: "linoleic acid monooxygenase activity" EXACT [GOC:mah]
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
created_by: midori
creation_date: 2010-02-05T06:05:22Z

[Term]
id: GO:0071615
name: oxidative deethylation
namespace: biological_process
def: "The process of removing one or more ethyl groups from a molecule, involving the oxidation (i.e. electron loss) of one or more atoms in the substrate." [GOC:BHF, GOC:mah, GOC:rl]
is_a: GO:0055114 ! oxidation-reduction process
created_by: midori
creation_date: 2010-02-05T06:11:41Z

[Term]
id: GO:0071616
name: acyl-CoA biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group." [GOC:cjk]
subset: gosubset_prok
synonym: "acyl-CoA anabolism" EXACT [GOC:mah]
synonym: "acyl-CoA biosynthesis" EXACT [GOC:mah]
synonym: "acyl-CoA formation" EXACT [GOC:mah]
synonym: "acyl-CoA synthesis" EXACT [GOC:mah]
is_a: GO:0006637 ! acyl-CoA metabolic process
is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0035384 ! thioester biosynthetic process
created_by: midori
creation_date: 2010-02-08T04:43:31Z

[Term]
id: GO:0071617
name: lysophospholipid acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of acyl groups from an acyl-CoA to a lysophospholipid." [GOC:cjk]
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups
created_by: midori
creation_date: 2010-02-08T04:53:37Z

[Term]
id: GO:0071618
name: lysophosphatidylethanolamine acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidylethanolamine." [GOC:cjk]
is_a: GO:0071617 ! lysophospholipid acyltransferase activity
created_by: midori
creation_date: 2010-02-08T04:59:07Z

[Term]
id: GO:0071619
name: phosphorylation of RNA polymerase II C-terminal domain serine 2 residues
namespace: biological_process
def: "The process of introducing a phosphate group onto a serine residue at position 2 within the heptapeptide repeat (YSPTSPS) of the C-terminal domain of RNA polymerase II. Typically, phosphorylation of serine 2 (Ser2) occurs subsequent to phosphorylation of serine 5 and is thus seen in the middle and 3' ends of genes. In vivo, Ser2 phosphorylation is primarily performed by CTDK-I in S. cerevisiae or CDK9 in metazoans." [GOC:krc, PMID:17079683]
is_a: GO:0070816 ! phosphorylation of RNA polymerase II C-terminal domain
created_by: midori
creation_date: 2010-02-09T02:37:02Z

[Term]
id: GO:0071620
name: phosphorylation of RNA polymerase II C-terminal domain serine 5 residues
namespace: biological_process
def: "The process of introducing a phosphate group onto a serine residue at position 5 within the heptapeptide repeat (YSPTSPS) of the C-terminal domain of RNA polymerase II. Typically, phosphorylation of serine 5 (Ser5) occurs near the 5' ends of genes. It is generally still observed in the middle of genes, overlapping with phosphorylation of serine 2, but is generally not present at the 3' ends of genes. In vivo, Ser5 phosphorylation occurs primarily through the action of TFIIH (KIN28 in S. cerevisiae, CKD7 in metazoans)." [GOC:krc, PMID:17079683]
is_a: GO:0070816 ! phosphorylation of RNA polymerase II C-terminal domain
created_by: midori
creation_date: 2010-02-09T02:39:52Z

[Term]
id: GO:0071621
name: granulocyte chemotaxis
namespace: biological_process
def: "The movement of a granulocyte in response to an external stimulus." [GOC:rph]
is_a: GO:0030595 ! leukocyte chemotaxis
is_a: GO:0097530 ! granulocyte migration
created_by: midori
creation_date: 2010-02-09T04:08:17Z

[Term]
id: GO:0071622
name: regulation of granulocyte chemotaxis
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus." [GOC:mah]
is_a: GO:0002688 ! regulation of leukocyte chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071621 ! granulocyte chemotaxis
relationship: regulates GO:0071621 ! granulocyte chemotaxis
created_by: midori
creation_date: 2010-02-09T04:09:24Z

[Term]
id: GO:0071623
name: negative regulation of granulocyte chemotaxis
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus." [GOC:mah]
is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis
is_a: GO:0071622 ! regulation of granulocyte chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071621 ! granulocyte chemotaxis
relationship: negatively_regulates GO:0071621 ! granulocyte chemotaxis
created_by: midori
creation_date: 2010-02-09T04:13:19Z

[Term]
id: GO:0071624
name: positive regulation of granulocyte chemotaxis
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus." [GOC:mah]
is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis
is_a: GO:0071622 ! regulation of granulocyte chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071621 ! granulocyte chemotaxis
relationship: positively_regulates GO:0071621 ! granulocyte chemotaxis
created_by: midori
creation_date: 2010-02-09T04:15:36Z

[Term]
id: GO:0071625
name: vocalization behavior
namespace: biological_process
def: "The behavior in which an organism produces sounds by a mechanism involving its respiratory system." [GOC:mah]
synonym: "vocalisation behaviour" EXACT [GOC:mah]
is_a: GO:0044708 ! single-organism behavior
created_by: midori
creation_date: 2010-02-10T11:02:58Z

[Term]
id: GO:0071626
name: mastication
namespace: biological_process
def: "The process of biting and mashing food with the teeth prior to swallowing." [GOC:gvg]
synonym: "chewing" EXACT [GOC:mah]
is_a: GO:0022600 ! digestive system process
created_by: midori
creation_date: 2010-02-10T11:19:48Z

[Term]
id: GO:0071627
name: integral component of fungal-type vacuolar membrane
namespace: cellular_component
def: "The component of the fungal-type vacuole membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]
synonym: "integral to fungal-type vacuolar membrane" NARROW []
is_a: GO:0031166 ! integral component of vacuolar membrane
is_a: GO:0071628 ! intrinsic component of fungal-type vacuolar membrane
intersection_of: GO:0016021 ! integral component of membrane
intersection_of: part_of GO:0000329 ! fungal-type vacuole membrane
relationship: part_of GO:0000329 ! fungal-type vacuole membrane
created_by: midori
creation_date: 2010-02-10T03:45:23Z

[Term]
id: GO:0071628
name: intrinsic component of fungal-type vacuolar membrane
namespace: cellular_component
def: "The component of a fungal-type vacuole membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
is_a: GO:0031310 ! intrinsic component of vacuolar membrane
intersection_of: GO:0031224 ! intrinsic component of membrane
intersection_of: part_of GO:0000329 ! fungal-type vacuole membrane
relationship: part_of GO:0000329 ! fungal-type vacuole membrane
created_by: midori
creation_date: 2010-02-10T03:53:00Z

[Term]
id: GO:0071629
name: cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of misfolded proteins in the cytoplasm, which are targeted to cytoplasmic proteasomes for degradation." [GOC:mah, GOC:rb, PMID:20080635]
comment: See also the biological process terms 'unfolded protein response ; GO:0030968' and 'retrograde protein transport, ER to cytosol ; GO:0030970'.
synonym: "cytoplasm-associated proteasomal ubiquitin-dependent protein breakdown" EXACT [GOC:mah]
synonym: "cytoplasm-associated proteasomal ubiquitin-dependent protein catabolism" EXACT [GOC:mah]
synonym: "cytoplasm-associated proteasomal ubiquitin-dependent protein degradation" EXACT [GOC:mah]
is_a: GO:0006515 ! misfolded or incompletely synthesized protein catabolic process
is_a: GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process
is_a: GO:0044712 ! single-organism catabolic process
is_a: GO:0044763 ! single-organism cellular process
relationship: part_of GO:0071218 ! cellular response to misfolded protein
created_by: midori
creation_date: 2010-02-11T03:06:57Z

[Term]
id: GO:0071630
name: nucleus-associated proteasomal ubiquitin-dependent protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of misfolded proteins via a mechanism in which the proteins are transported to the nucleus for ubiquitination, and then targeted to proteasomes for degradation." [GOC:mah, GOC:rb, PMID:20080635]
comment: See also the biological process terms 'unfolded protein response ; GO:0030968' and 'retrograde protein transport, ER to cytosol ; GO:0030970'.
synonym: "nucleus-associated proteasomal ubiquitin-dependent protein breakdown" EXACT [GOC:mah]
synonym: "nucleus-associated proteasomal ubiquitin-dependent protein catabolism" EXACT [GOC:mah]
synonym: "nucleus-associated proteasomal ubiquitin-dependent protein degradation" EXACT [GOC:mah]
is_a: GO:0006515 ! misfolded or incompletely synthesized protein catabolic process
is_a: GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process
is_a: GO:0044712 ! single-organism catabolic process
is_a: GO:0044763 ! single-organism cellular process
relationship: part_of GO:0071218 ! cellular response to misfolded protein
created_by: midori
creation_date: 2010-02-11T03:31:46Z

[Term]
id: GO:0071631
name: mating pheromone secretion involved in conjugation with cellular fusion
namespace: biological_process
def: "The regulated release of a mating pheromone, a peptide hormone that induces a behavioral or physiological response(s) from a responding organism or cell, that contributes to a conjugation process that results in the union of cellular and genetic information from compatible mating types." [GOC:elh, GOC:jh, GOC:mah]
synonym: "mating-type pheromone secretion involved in conjugation with cellular fusion" EXACT [GOC:vw]
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0071835 ! mating pheromone secretion involved in conjugation
intersection_of: GO:0071834 ! mating pheromone secretion
intersection_of: part_of GO:0000747 ! conjugation with cellular fusion
relationship: part_of GO:0000747 ! conjugation with cellular fusion
created_by: midori
creation_date: 2010-02-11T03:36:57Z

[Term]
id: GO:0071632
name: optomotor response
namespace: biological_process
def: "Eye, head or whole body movements that help to compensate movements of the environment in order to stabilize its image on the retina. In the case of whole body movements, these motor actions may also stabilize a locomotor course in response to some disturbance. Examples include: the optokinetic reflex, which allows human eyes to follow objects in motion while the head remains stationary reflex; the optomotor responses of flying insects and swimming fish." [GOC:dos, PMID:12726833, PMID:2469195]
xref: Wikipedia:Optomotor_response
is_a: GO:0007634 ! optokinetic behavior
created_by: midori
creation_date: 2010-02-11T04:06:41Z

[Term]
id: GO:0071633
name: dihydroceramidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a dihydroceramide + H2O = a fatty acid + dihydrosphingosine." [GOC:mah, PMID:10900202]
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds
is_a: GO:0017040 ! ceramidase activity
created_by: midori
creation_date: 2010-02-11T04:24:12Z

[Term]
id: GO:0071634
name: regulation of transforming growth factor beta production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta." [GOC:mah]
synonym: "regulation of TGF-B production" EXACT [GOC:mah]
synonym: "regulation of TGF-beta production" EXACT [GOC:mah]
synonym: "regulation of TGFB production" EXACT [GOC:mah]
synonym: "regulation of transforming growth factor-beta production" EXACT [GOC:bf]
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071604 ! transforming growth factor beta production
relationship: regulates GO:0071604 ! transforming growth factor beta production
created_by: midori
creation_date: 2010-02-12T10:33:07Z

[Term]
id: GO:0071635
name: negative regulation of transforming growth factor beta production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta." [GOC:mah]
synonym: "negative regulation of TGF-B production" EXACT [GOC:mah]
synonym: "negative regulation of TGF-beta production" EXACT [GOC:mah]
synonym: "negative regulation of TGFB production" EXACT [GOC:mah]
synonym: "negative regulation of transforming growth factor-beta production" EXACT [GOC:bf]
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0071634 ! regulation of transforming growth factor beta production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071604 ! transforming growth factor beta production
relationship: negatively_regulates GO:0071604 ! transforming growth factor beta production
created_by: midori
creation_date: 2010-02-12T10:39:51Z

[Term]
id: GO:0071636
name: positive regulation of transforming growth factor beta production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta." [GOC:mah]
synonym: "positive regulation of TGF-B production" EXACT [GOC:mah]
synonym: "positive regulation of TGF-beta production" EXACT [GOC:mah]
synonym: "positive regulation of TGFB production" EXACT [GOC:mah]
synonym: "positive regulation of transforming growth factor-beta production" EXACT [GOC:bf]
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0071634 ! regulation of transforming growth factor beta production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071604 ! transforming growth factor beta production
relationship: positively_regulates GO:0071604 ! transforming growth factor beta production
created_by: midori
creation_date: 2010-02-12T10:39:51Z

[Term]
id: GO:0071637
name: regulation of monocyte chemotactic protein-1 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of monocyte chemotactic protein-1." [GOC:mah]
synonym: "regulation of CCL2 production" EXACT [GOC:mah]
synonym: "regulation of MCP-1 production" EXACT [GOC:mah]
is_a: GO:0032642 ! regulation of chemokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071605 ! monocyte chemotactic protein-1 production
relationship: regulates GO:0071605 ! monocyte chemotactic protein-1 production
created_by: midori
creation_date: 2010-02-12T10:39:51Z

[Term]
id: GO:0071638
name: negative regulation of monocyte chemotactic protein-1 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of monocyte chemotactic protein-1." [GOC:mah]
synonym: "negative regulation of CCL2 production" EXACT [GOC:mah]
synonym: "negative regulation of MCP-1 production" EXACT [GOC:mah]
is_a: GO:0032682 ! negative regulation of chemokine production
is_a: GO:0071637 ! regulation of monocyte chemotactic protein-1 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071605 ! monocyte chemotactic protein-1 production
relationship: negatively_regulates GO:0071605 ! monocyte chemotactic protein-1 production
created_by: midori
creation_date: 2010-02-12T10:39:51Z

[Term]
id: GO:0071639
name: positive regulation of monocyte chemotactic protein-1 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of production of monocyte chemotactic protein-1." [GOC:mah]
synonym: "positive regulation of CCL2 production" EXACT [GOC:mah]
synonym: "positive regulation of MCP-1 production" EXACT [GOC:mah]
is_a: GO:0032722 ! positive regulation of chemokine production
is_a: GO:0071637 ! regulation of monocyte chemotactic protein-1 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071605 ! monocyte chemotactic protein-1 production
relationship: positively_regulates GO:0071605 ! monocyte chemotactic protein-1 production
created_by: midori
creation_date: 2010-02-12T10:39:51Z

[Term]
id: GO:0071640
name: regulation of macrophage inflammatory protein 1 alpha production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of macrophage inflammatory protein 1 alpha." [GOC:mah]
synonym: "regulation of CCL3 production" EXACT [GOC:mah]
synonym: "regulation of chemokine (C-C motif) ligand 3 production" EXACT [GOC:mah]
synonym: "regulation of macrophage inflammatory protein production" BROAD [GOC:mah]
synonym: "regulation of MIP-1a production" EXACT [GOC:mah]
is_a: GO:0032642 ! regulation of chemokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071608 ! macrophage inflammatory protein-1 alpha production
relationship: regulates GO:0071608 ! macrophage inflammatory protein-1 alpha production
created_by: midori
creation_date: 2010-02-12T10:39:51Z

[Term]
id: GO:0071641
name: negative regulation of macrophage inflammatory protein 1 alpha production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of macrophage inflammatory protein 1 alpha." [GOC:mah]
synonym: "negative regulation of CCL3 production" EXACT [GOC:mah]
synonym: "negative regulation of chemokine (C-C motif) ligand 3 production" EXACT [GOC:mah]
synonym: "negative regulation of macrophage inflammatory protein production" BROAD [GOC:mah]
synonym: "negative regulation of MIP-1a production" EXACT [GOC:mah]
is_a: GO:0032682 ! negative regulation of chemokine production
is_a: GO:0071640 ! regulation of macrophage inflammatory protein 1 alpha production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071608 ! macrophage inflammatory protein-1 alpha production
relationship: negatively_regulates GO:0071608 ! macrophage inflammatory protein-1 alpha production
created_by: midori
creation_date: 2010-02-12T10:39:51Z

[Term]
id: GO:0071642
name: positive regulation of macrophage inflammatory protein 1 alpha production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of production of macrophage inflammatory protein 1 alpha." [GOC:mah]
synonym: "positive regulation of CCL3 production" EXACT [GOC:mah]
synonym: "positive regulation of chemokine (C-C motif) ligand 3 production" EXACT [GOC:mah]
synonym: "positive regulation of macrophage inflammatory protein production" BROAD [GOC:mah]
synonym: "positive regulation of MIP-1a production" EXACT [GOC:mah]
is_a: GO:0032722 ! positive regulation of chemokine production
is_a: GO:0071640 ! regulation of macrophage inflammatory protein 1 alpha production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071608 ! macrophage inflammatory protein-1 alpha production
relationship: positively_regulates GO:0071608 ! macrophage inflammatory protein-1 alpha production
created_by: midori
creation_date: 2010-02-12T10:39:51Z

[Term]
id: GO:0071643
name: regulation of chemokine (C-C motif) ligand 4 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of chemokine (C-C motif) ligand 4." [GOC:mah]
synonym: "regulation of CCL4 production" EXACT [GOC:mah]
synonym: "regulation of macrophage inflammatory protein production" BROAD [GOC:mah]
synonym: "regulation of MIP-1b production" EXACT [GOC:mah]
is_a: GO:0032642 ! regulation of chemokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071606 ! chemokine (C-C motif) ligand 4 production
relationship: regulates GO:0071606 ! chemokine (C-C motif) ligand 4 production
created_by: midori
creation_date: 2010-02-12T10:39:51Z

[Term]
id: GO:0071644
name: negative regulation of chemokine (C-C motif) ligand 4 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-C motif) ligand 4." [GOC:mah]
synonym: "negative regulation of CCL4 production" EXACT [GOC:mah]
synonym: "negative regulation of macrophage inflammatory protein production" BROAD [GOC:mah]
synonym: "negative regulation of MIP-1b production" EXACT [GOC:mah]
is_a: GO:0032682 ! negative regulation of chemokine production
is_a: GO:0071643 ! regulation of chemokine (C-C motif) ligand 4 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071606 ! chemokine (C-C motif) ligand 4 production
relationship: negatively_regulates GO:0071606 ! chemokine (C-C motif) ligand 4 production
created_by: midori
creation_date: 2010-02-12T10:40:19Z

[Term]
id: GO:0071645
name: positive regulation of chemokine (C-C motif) ligand 4 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-C motif) ligand 4." [GOC:mah]
synonym: "positive regulation of CCL4 production" EXACT [GOC:mah]
synonym: "positive regulation of macrophage inflammatory protein production" BROAD [GOC:mah]
synonym: "positive regulation of MIP-1b production" EXACT [GOC:mah]
is_a: GO:0032722 ! positive regulation of chemokine production
is_a: GO:0071643 ! regulation of chemokine (C-C motif) ligand 4 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071606 ! chemokine (C-C motif) ligand 4 production
relationship: positively_regulates GO:0071606 ! chemokine (C-C motif) ligand 4 production
created_by: midori
creation_date: 2010-02-12T10:40:19Z

[Term]
id: GO:0071646
name: regulation of macrophage inflammatory protein-1 gamma production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of macrophage inflammatory protein-1 gamma." [GOC:mah]
synonym: "regulation of CCL9 production" EXACT [GOC:mah]
synonym: "regulation of chemokine (C-C motif) ligand 9 production" EXACT [GOC:mah]
synonym: "regulation of MIP-1g production" EXACT [GOC:mah]
is_a: GO:0032642 ! regulation of chemokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071607 ! macrophage inflammatory protein-1 gamma production
relationship: regulates GO:0071607 ! macrophage inflammatory protein-1 gamma production
created_by: midori
creation_date: 2010-02-12T10:40:19Z

[Term]
id: GO:0071647
name: negative regulation of macrophage inflammatory protein-1 gamma production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of macrophage inflammatory protein-1 gamma." [GOC:mah]
synonym: "negative regulation of CCL9 production" EXACT [GOC:mah]
synonym: "negative regulation of chemokine (C-C motif) ligand 9 production" EXACT [GOC:mah]
synonym: "negative regulation of MIP-1g production" EXACT [GOC:mah]
is_a: GO:0032682 ! negative regulation of chemokine production
is_a: GO:0071646 ! regulation of macrophage inflammatory protein-1 gamma production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071607 ! macrophage inflammatory protein-1 gamma production
relationship: negatively_regulates GO:0071607 ! macrophage inflammatory protein-1 gamma production
created_by: midori
creation_date: 2010-02-12T10:40:19Z

[Term]
id: GO:0071648
name: positive regulation of macrophage inflammatory protein-1 gamma production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of production of macrophage inflammatory protein-1 gamma." [GOC:mah]
synonym: "positive regulation of CCL9 production" EXACT [GOC:mah]
synonym: "positive regulation of chemokine (C-C motif) ligand 9 production" EXACT [GOC:mah]
synonym: "positive regulation of MIP-1g production" EXACT [GOC:mah]
is_a: GO:0032722 ! positive regulation of chemokine production
is_a: GO:0071646 ! regulation of macrophage inflammatory protein-1 gamma production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071607 ! macrophage inflammatory protein-1 gamma production
relationship: positively_regulates GO:0071607 ! macrophage inflammatory protein-1 gamma production
created_by: midori
creation_date: 2010-02-12T10:40:19Z

[Term]
id: GO:0071649
name: regulation of chemokine (C-C motif) ligand 5 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of chemokine (C-C motif) ligand 5." [GOC:mah]
synonym: "regulation of CCL5 production" EXACT [GOC:mah]
synonym: "regulation of RANTES production" EXACT [GOC:bf]
synonym: "regulation of Regulated upon Activation, Normal T-cell Expressed, and Secreted production" EXACT [GOC:mah]
is_a: GO:0032642 ! regulation of chemokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071609 ! chemokine (C-C motif) ligand 5 production
relationship: regulates GO:0071609 ! chemokine (C-C motif) ligand 5 production
created_by: midori
creation_date: 2010-02-12T10:40:19Z

[Term]
id: GO:0071650
name: negative regulation of chemokine (C-C motif) ligand 5 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-C motif) ligand 5." [GOC:mah]
synonym: "negative regulation of CCL5 production" EXACT [GOC:mah]
synonym: "negative regulation of RANTES production" EXACT [GOC:bf]
synonym: "negative regulation of Regulated upon Activation, Normal T-cell Expressed, and Secreted production" EXACT [GOC:mah]
is_a: GO:0032682 ! negative regulation of chemokine production
is_a: GO:0071649 ! regulation of chemokine (C-C motif) ligand 5 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071609 ! chemokine (C-C motif) ligand 5 production
relationship: negatively_regulates GO:0071609 ! chemokine (C-C motif) ligand 5 production
created_by: midori
creation_date: 2010-02-12T10:40:19Z

[Term]
id: GO:0071651
name: positive regulation of chemokine (C-C motif) ligand 5 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-C motif) ligand 5." [GOC:mah]
synonym: "positive regulation of CCL5 production" EXACT [GOC:mah]
synonym: "positive regulation of RANTES production" EXACT [GOC:bf]
synonym: "positive regulation of Regulated upon Activation, Normal T-cell Expressed, and Secreted production" EXACT [GOC:mah]
is_a: GO:0032722 ! positive regulation of chemokine production
is_a: GO:0071649 ! regulation of chemokine (C-C motif) ligand 5 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071609 ! chemokine (C-C motif) ligand 5 production
relationship: positively_regulates GO:0071609 ! chemokine (C-C motif) ligand 5 production
created_by: midori
creation_date: 2010-02-12T10:40:19Z

[Term]
id: GO:0071652
name: regulation of chemokine (C-C motif) ligand 1 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of chemokine (C-C motif) ligand 1." [GOC:mah]
synonym: "regulation of CCL1 production" EXACT [GOC:mah]
synonym: "regulation of T cell activation 3 production" EXACT [GOC:mah]
synonym: "regulation of TCA-3 production" EXACT [GOC:mah]
is_a: GO:0032642 ! regulation of chemokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071610 ! chemokine (C-C motif) ligand 1 production
relationship: regulates GO:0071610 ! chemokine (C-C motif) ligand 1 production
created_by: midori
creation_date: 2010-02-12T10:40:19Z

[Term]
id: GO:0071653
name: negative regulation of chemokine (C-C motif) ligand 1 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-C motif) ligand 1." [GOC:mah]
synonym: "negative regulation of CCL1 production" EXACT [GOC:mah]
synonym: "negative regulation of T cell activation 3 production" EXACT [GOC:mah]
synonym: "negative regulation of TCA-3 production" EXACT [GOC:mah]
is_a: GO:0032682 ! negative regulation of chemokine production
is_a: GO:0071652 ! regulation of chemokine (C-C motif) ligand 1 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071610 ! chemokine (C-C motif) ligand 1 production
relationship: negatively_regulates GO:0071610 ! chemokine (C-C motif) ligand 1 production
created_by: midori
creation_date: 2010-02-12T10:41:14Z

[Term]
id: GO:0071654
name: positive regulation of chemokine (C-C motif) ligand 1 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-C motif) ligand 1." [GOC:mah]
synonym: "positive regulation of CCL1 production" EXACT [GOC:mah]
synonym: "positive regulation of T cell activation 3 production" EXACT [GOC:mah]
synonym: "positive regulation of TCA-3 production" EXACT [GOC:mah]
is_a: GO:0032722 ! positive regulation of chemokine production
is_a: GO:0071652 ! regulation of chemokine (C-C motif) ligand 1 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071610 ! chemokine (C-C motif) ligand 1 production
relationship: positively_regulates GO:0071610 ! chemokine (C-C motif) ligand 1 production
created_by: midori
creation_date: 2010-02-12T10:41:14Z

[Term]
id: GO:0071655
name: regulation of granulocyte colony-stimulating factor production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of granulocyte colony-stimulating factor." [GOC:mah]
synonym: "regulation of colony stimulating factor 3 (granulocyte) production" EXACT [GOC:mah]
synonym: "regulation of CSF3 production" EXACT [GOC:mah]
synonym: "regulation of filgrastim production" EXACT [GOC:mah]
synonym: "regulation of G-CSF production" EXACT [GOC:mah]
synonym: "regulation of granulocyte colony stimulating factor production" EXACT []
synonym: "regulation of lenograstim production" EXACT [GOC:mah]
synonym: "regulation of pluripoietin production" EXACT [GOC:mah]
is_a: GO:1901256 ! regulation of macrophage colony-stimulating factor production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071611 ! granulocyte colony-stimulating factor production
relationship: regulates GO:0036301 ! macrophage colony-stimulating factor production
relationship: regulates GO:0071611 ! granulocyte colony-stimulating factor production
created_by: midori
creation_date: 2010-02-12T10:41:14Z

[Term]
id: GO:0071656
name: negative regulation of granulocyte colony-stimulating factor production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of granulocyte colony stimulating factor." [GOC:mah]
synonym: "negative regulation of colony stimulating factor 3 (granulocyte) production" EXACT [GOC:mah]
synonym: "negative regulation of CSF3 production" EXACT [GOC:mah]
synonym: "negative regulation of filgrastim production" EXACT [GOC:mah]
synonym: "negative regulation of G-CSF production" EXACT [GOC:mah]
synonym: "negative regulation of granulocyte colony stimulating factor production" EXACT []
synonym: "negative regulation of lenograstim production" EXACT [GOC:mah]
synonym: "negative regulation of pluripoietin production" EXACT [GOC:mah]
is_a: GO:0071655 ! regulation of granulocyte colony-stimulating factor production
is_a: GO:1901257 ! negative regulation of macrophage colony-stimulating factor production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071611 ! granulocyte colony-stimulating factor production
relationship: negatively_regulates GO:0036301 ! macrophage colony-stimulating factor production
relationship: negatively_regulates GO:0071611 ! granulocyte colony-stimulating factor production
created_by: midori
creation_date: 2010-02-12T10:41:14Z

[Term]
id: GO:0071657
name: positive regulation of granulocyte colony-stimulating factor production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of production of granulocyte colony-stimulating factor." [GOC:mah]
synonym: "positive regulation of colony stimulating factor 3 (granulocyte) production" EXACT [GOC:mah]
synonym: "positive regulation of CSF3 production" EXACT [GOC:mah]
synonym: "positive regulation of filgrastim production" EXACT [GOC:mah]
synonym: "positive regulation of G-CSF production" EXACT [GOC:mah]
synonym: "positive regulation of granulocyte colony stimulating factor production" EXACT []
synonym: "positive regulation of lenograstim production" EXACT [GOC:mah]
synonym: "positive regulation of pluripoietin production" EXACT [GOC:mah]
is_a: GO:0071655 ! regulation of granulocyte colony-stimulating factor production
is_a: GO:1901258 ! positive regulation of macrophage colony-stimulating factor production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071611 ! granulocyte colony-stimulating factor production
relationship: positively_regulates GO:0036301 ! macrophage colony-stimulating factor production
relationship: positively_regulates GO:0071611 ! granulocyte colony-stimulating factor production
created_by: midori
creation_date: 2010-02-12T10:41:14Z

[Term]
id: GO:0071658
name: regulation of IP-10 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of IP-10." [GOC:mah]
synonym: "regulation of chemokine (C-C motif) ligand 10 production" EXACT [GOC:mah]
synonym: "regulation of CXCL10 production" EXACT [GOC:mah]
is_a: GO:0032642 ! regulation of chemokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071612 ! IP-10 production
relationship: regulates GO:0071612 ! IP-10 production
created_by: midori
creation_date: 2010-02-12T10:41:14Z

[Term]
id: GO:0071659
name: negative regulation of IP-10 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of IP-10." [GOC:mah]
synonym: "negative regulation of chemokine (C-C motif) ligand 10 production" EXACT [GOC:mah]
synonym: "negative regulation of CXCL10 production" EXACT [GOC:mah]
is_a: GO:0032682 ! negative regulation of chemokine production
is_a: GO:0071658 ! regulation of IP-10 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071612 ! IP-10 production
relationship: negatively_regulates GO:0071612 ! IP-10 production
created_by: midori
creation_date: 2010-02-12T10:41:14Z

[Term]
id: GO:0071660
name: positive regulation of IP-10 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of production of IP-10." [GOC:mah]
synonym: "positive regulation of chemokine (C-C motif) ligand 10 production" EXACT [GOC:mah]
synonym: "positive regulation of CXCL10 production" EXACT [GOC:mah]
is_a: GO:0032722 ! positive regulation of chemokine production
is_a: GO:0071658 ! regulation of IP-10 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071612 ! IP-10 production
relationship: positively_regulates GO:0071612 ! IP-10 production
created_by: midori
creation_date: 2010-02-12T10:41:14Z

[Term]
id: GO:0071661
name: regulation of granzyme B production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of granzyme B." [GOC:mah]
is_a: GO:0001817 ! regulation of cytokine production
is_a: GO:0002700 ! regulation of production of molecular mediator of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071613 ! granzyme B production
relationship: regulates GO:0071613 ! granzyme B production
created_by: midori
creation_date: 2010-02-12T10:41:14Z

[Term]
id: GO:0071662
name: negative regulation of granzyme B production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of granzyme B." [GOC:mah]
is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response
is_a: GO:0071661 ! regulation of granzyme B production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071613 ! granzyme B production
relationship: negatively_regulates GO:0071613 ! granzyme B production
created_by: midori
creation_date: 2010-02-12T10:41:14Z

[Term]
id: GO:0071663
name: positive regulation of granzyme B production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of production of granzyme B." [GOC:mah]
is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response
is_a: GO:0071661 ! regulation of granzyme B production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071613 ! granzyme B production
relationship: positively_regulates GO:0071613 ! granzyme B production
created_by: midori
creation_date: 2010-02-12T10:41:14Z

[Term]
id: GO:0071664
name: catenin-TCF7L2 complex
namespace: cellular_component
def: "A protein complex that contains a catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription." [GOC:BHF, GOC:rl, GOC:vk, PMID:14661054]
subset: gosubset_prok
synonym: "catenin-TCF4 complex" EXACT [GOC:mah]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part
created_by: midori
creation_date: 2010-02-12T03:19:16Z

[Term]
id: GO:0071665
name: gamma-catenin-TCF7L2 complex
namespace: cellular_component
def: "A protein complex that contains gamma-catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription." [GOC:BHF, GOC:vk, PMID:14661054]
subset: gosubset_prok
synonym: "gamma-catenin-TCF4 complex" EXACT [GOC:mah]
synonym: "plakoglobin-TCF4 complex" EXACT [PMID:14661054]
is_a: GO:0071664 ! catenin-TCF7L2 complex
created_by: midori
creation_date: 2010-02-12T03:23:08Z

[Term]
id: GO:0071666
name: Slit-Robo signaling complex
namespace: cellular_component
def: "A protein-carbohydrate complex that consists of a transmembrane roundabout (Robo) receptor, an extracellular Slit ligand and heparin/heparan sulfate." [GOC:sart, PMID:17062560, PMID:18359766]
synonym: "Slit-Robo signalling complex" EXACT [GOC:mah]
is_a: GO:0032992 ! protein-carbohydrate complex
created_by: midori
creation_date: 2010-02-12T03:35:28Z

[Term]
id: GO:0071667
name: DNA/RNA hybrid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a RNA/DNA hybrid." [GOC:ecd]
synonym: "RNA/DNA hybrid binding" EXACT [GOC:ecd]
is_a: GO:0003676 ! nucleic acid binding
created_by: midori
creation_date: 2010-02-15T01:51:44Z

[Term]
id: GO:0071668
name: plant-type cell wall assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a cellulose- and pectin-containing cell wall." [GOC:mah]
synonym: "plant cell wall assembly" NARROW []
is_a: GO:0009664 ! plant-type cell wall organization
is_a: GO:0070726 ! cell wall assembly
relationship: part_of GO:0009832 ! plant-type cell wall biogenesis
created_by: midori
creation_date: 2010-02-15T02:19:39Z

[Term]
id: GO:0071669
name: plant-type cell wall organization or biogenesis
namespace: biological_process
def: "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellulose- and pectin-containing cell wall." [GOC:ecd, GOC:mah]
synonym: "plant-type cell wall organisation or biogenesis" EXACT [GOC:mah]
synonym: "plant-type cell wall organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0071554 ! cell wall organization or biogenesis
created_by: midori
creation_date: 2010-02-15T02:32:10Z

[Term]
id: GO:0071670
name: smooth muscle cell chemotaxis
namespace: biological_process
def: "The directed movement of a smooth muscle cell in response to an external stimulus." [GOC:mah]
is_a: GO:0014909 ! smooth muscle cell migration
is_a: GO:0060326 ! cell chemotaxis
created_by: midori
creation_date: 2010-02-16T01:32:59Z

[Term]
id: GO:0071671
name: regulation of smooth muscle cell chemotaxis
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of smooth muscle cell chemotaxis." [GOC:mah]
is_a: GO:0014910 ! regulation of smooth muscle cell migration
is_a: GO:0050920 ! regulation of chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071670 ! smooth muscle cell chemotaxis
relationship: regulates GO:0071670 ! smooth muscle cell chemotaxis
created_by: midori
creation_date: 2010-02-16T01:42:03Z

[Term]
id: GO:0071672
name: negative regulation of smooth muscle cell chemotaxis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell chemotaxis." [GOC:mah]
synonym: "down regulation of smooth muscle cell chemotaxis" EXACT [GOC:mah]
synonym: "down-regulation of smooth muscle cell chemotaxis" EXACT [GOC:mah]
synonym: "downregulation of smooth muscle cell chemotaxis" EXACT [GOC:mah]
synonym: "inhibition of smooth muscle cell chemotaxis" NARROW [GOC:mah]
is_a: GO:0014912 ! negative regulation of smooth muscle cell migration
is_a: GO:0050922 ! negative regulation of chemotaxis
is_a: GO:0071671 ! regulation of smooth muscle cell chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071670 ! smooth muscle cell chemotaxis
relationship: negatively_regulates GO:0071670 ! smooth muscle cell chemotaxis
created_by: midori
creation_date: 2010-02-16T01:44:28Z

[Term]
id: GO:0071673
name: positive regulation of smooth muscle cell chemotaxis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of smooth muscle cell chemotaxis." [GOC:mah]
synonym: "activation of smooth muscle cell chemotaxis" NARROW [GOC:mah]
synonym: "stimulation of smooth muscle cell chemotaxis" NARROW [GOC:mah]
synonym: "up regulation of smooth muscle cell chemotaxis" EXACT [GOC:mah]
synonym: "up-regulation of smooth muscle cell chemotaxis" EXACT [GOC:mah]
synonym: "upregulation of smooth muscle cell chemotaxis" EXACT [GOC:mah]
is_a: GO:0014911 ! positive regulation of smooth muscle cell migration
is_a: GO:0050921 ! positive regulation of chemotaxis
is_a: GO:0071671 ! regulation of smooth muscle cell chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071670 ! smooth muscle cell chemotaxis
relationship: positively_regulates GO:0071670 ! smooth muscle cell chemotaxis
created_by: midori
creation_date: 2010-02-16T01:48:14Z

[Term]
id: GO:0071674
name: mononuclear cell migration
namespace: biological_process
def: "The movement of a mononuclear cell within or between different tissues and organs of the body." [GOC:mah]
is_a: GO:0050900 ! leukocyte migration
created_by: midori
creation_date: 2010-02-16T02:11:00Z

[Term]
id: GO:0071675
name: regulation of mononuclear cell migration
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body." [GOC:mah]
is_a: GO:0002685 ! regulation of leukocyte migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071674 ! mononuclear cell migration
relationship: regulates GO:0071674 ! mononuclear cell migration
created_by: midori
creation_date: 2010-02-16T02:11:53Z

[Term]
id: GO:0071676
name: negative regulation of mononuclear cell migration
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body." [GOC:mah]
synonym: "down regulation of mononuclear cell migration" EXACT [GOC:mah]
synonym: "down-regulation of mononuclear cell migration" EXACT [GOC:mah]
synonym: "downregulation of mononuclear cell migration" EXACT [GOC:mah]
synonym: "inhibition of mononuclear cell migration" NARROW [GOC:mah]
is_a: GO:0002686 ! negative regulation of leukocyte migration
is_a: GO:0071675 ! regulation of mononuclear cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071674 ! mononuclear cell migration
relationship: negatively_regulates GO:0071674 ! mononuclear cell migration
created_by: midori
creation_date: 2010-02-16T02:13:55Z

[Term]
id: GO:0071677
name: positive regulation of mononuclear cell migration
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body." [GOC:mah]
synonym: "activation of mononuclear cell migration" NARROW [GOC:mah]
synonym: "stimulation of mononuclear cell migration" NARROW [GOC:mah]
synonym: "up regulation of mononuclear cell migration" EXACT [GOC:mah]
synonym: "up-regulation of mononuclear cell migration" EXACT [GOC:mah]
synonym: "upregulation of mononuclear cell migration" EXACT [GOC:mah]
is_a: GO:0002687 ! positive regulation of leukocyte migration
is_a: GO:0071675 ! regulation of mononuclear cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071674 ! mononuclear cell migration
relationship: positively_regulates GO:0071674 ! mononuclear cell migration
created_by: midori
creation_date: 2010-02-16T02:15:29Z

[Term]
id: GO:0071678
name: olfactory bulb axon guidance
namespace: biological_process
def: "The process in which the migration of an axon growth cone of a neuron in the olfactory bulb is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:BHF, GOC:mah]
synonym: "olfactory bulb axon pathfinding" EXACT [GOC:vk]
is_a: GO:0007411 ! axon guidance
created_by: midori
creation_date: 2010-02-17T02:09:34Z

[Term]
id: GO:0071679
name: commissural neuron axon guidance
namespace: biological_process
def: "The process in which the migration of an axon growth cone of a commissural neuron is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:BHF, GOC:mah]
synonym: "commissural neuron axon pathfinding" EXACT [GOC:vk]
is_a: GO:0007411 ! axon guidance
created_by: midori
creation_date: 2010-02-17T02:21:36Z

[Term]
id: GO:0071680
name: response to indole-3-methanol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indole-3-methanol stimulus." [CHEBI:24814, GOC:mah, GOC:yaf]
synonym: "response to indole-3-carbinol" EXACT [CHEBI:24814]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0097305 ! response to alcohol
created_by: midori
creation_date: 2010-02-18T04:05:09Z

[Term]
id: GO:0071681
name: cellular response to indole-3-methanol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indole-3-methanol stimulus." [CHEBI:24814, GOC:mah, GOC:yaf]
synonym: "cellular response to indole-3-carbinol" EXACT [CHEBI:24814]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:0071680 ! response to indole-3-methanol
is_a: GO:0097306 ! cellular response to alcohol
created_by: midori
creation_date: 2010-02-18T04:05:29Z

[Term]
id: GO:0071682
name: endocytic vesicle lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of an endocytic vesicle." [GOC:pde]
is_a: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen
relationship: part_of GO:0030139 ! endocytic vesicle
created_by: midori
creation_date: 2010-02-18T04:21:53Z

[Term]
id: GO:0071683
name: sensory dendrite
namespace: cellular_component
def: "A dendrite that is found on a sensory neuron, and directly transduces a sensory signal from the sensory neuron to another neuron." [GOC:dos, GOC:kmv, GOC:mah]
is_a: GO:0030425 ! dendrite
created_by: midori
creation_date: 2010-02-19T04:17:05Z

[Term]
id: GO:0071684
name: organism emergence from protective structure
namespace: biological_process
def: "The developmental process in which an organism emerges from a surrounding protective structure such as an egg or pupa case." [GOC:mah]
is_a: GO:0044707 ! single-multicellular organism process
is_a: GO:0044767 ! single-organism developmental process
created_by: midori
creation_date: 2010-02-19T04:23:55Z

[Term]
id: GO:0071685
name: NADH dehydrogenase complex (plastoquinone)
namespace: cellular_component
def: "An NADH dehydrogenase complex that catalyzes the transfer of electrons to plastoquinone. The complex is involved in the non-photochemical reduction of plastoquinones and the cyclic electron transport around photosystem I, and is found in plastid thylakoids." [DOI:10.1078/0176-1617-00593, GOC:mah]
is_a: GO:0030964 ! NADH dehydrogenase complex
is_a: GO:0044435 ! plastid part
is_a: GO:0044436 ! thylakoid part
relationship: part_of GO:0031976 ! plastid thylakoid
created_by: midori
creation_date: 2010-02-19T05:20:45Z

[Term]
id: GO:0071686
name: horsetail nucleus
namespace: cellular_component
def: "The elongated nucleus which forms during the rapid oscillatory movement at meiotic prophase; characterized in Schizosaccharomyces pombe." [GOC:vw, PMID:15030757]
is_a: GO:0005634 ! nucleus
created_by: midori
creation_date: 2010-02-22T04:52:01Z

[Term]
id: GO:0071687
name: horsetail nucleus leading edge
namespace: cellular_component
def: "The part of the horsetail nucleus where telomeres cluster under the SPB and that leads horsetail movement. The horsetail nucleus is the elongated nucleus which forms during the rapid oscillatory movement at meiotic prophase; characterized in Schizosaccharomyces pombe." [GOC:mah, GOC:vw, PMID:15030757]
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0071686 ! horsetail nucleus
created_by: midori
creation_date: 2010-02-22T05:04:40Z

[Term]
id: GO:0071688
name: striated muscle myosin thick filament assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins to form the myosin-based thick filaments of myofibrils in striated muscle." [GOC:mah]
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
is_a: GO:0031034 ! myosin filament assembly
relationship: part_of GO:0030239 ! myofibril assembly
created_by: midori
creation_date: 2010-02-25T03:52:21Z

[Term]
id: GO:0071689
name: muscle thin filament assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins to form the actin-based thin filaments of myofibrils in striated muscle." [GOC:mah]
is_a: GO:0007015 ! actin filament organization
relationship: part_of GO:0030239 ! myofibril assembly
created_by: midori
creation_date: 2010-02-25T03:54:06Z

[Term]
id: GO:0071690
name: cardiac muscle myosin thick filament assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins to form the myosin-based thick filaments of myofibrils in cardiac muscle." [GOC:mah]
is_a: GO:0071688 ! striated muscle myosin thick filament assembly
relationship: part_of GO:0055003 ! cardiac myofibril assembly
created_by: midori
creation_date: 2010-02-25T03:55:44Z

[Term]
id: GO:0071691
name: cardiac muscle thin filament assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins to form the actin-based thin filaments of myofibrils in cardiac muscle." [GOC:mah]
is_a: GO:0007015 ! actin filament organization
relationship: part_of GO:0055003 ! cardiac myofibril assembly
created_by: midori
creation_date: 2010-02-25T03:57:01Z

[Term]
id: GO:0071692
name: protein localization to extracellular region
namespace: biological_process
def: "Any process in which a protein is transported from one specific location in the extracellular region to another, or maintained in a specific extracellular location." [GOC:mah]
synonym: "protein localisation in extracellular region" EXACT [GOC:mah]
synonym: "protein localization in extracellular region" EXACT [GOC:curators]
is_a: GO:0008104 ! protein localization
created_by: midori
creation_date: 2010-02-25T04:00:13Z

[Term]
id: GO:0071693
name: protein transport within extracellular region
namespace: biological_process
def: "The directed movement of proteins in the extracellular region, by means of some agent such as a transporter or pore." [GOC:mah]
is_a: GO:0015031 ! protein transport
is_a: GO:0035592 ! establishment of protein localization to extracellular region
is_a: GO:0044765 ! single-organism transport
is_a: GO:0071692 ! protein localization to extracellular region
created_by: midori
creation_date: 2010-02-25T04:02:35Z

[Term]
id: GO:0071694
name: maintenance of protein location in extracellular region
namespace: biological_process
def: "Any process in which a protein is maintained in a specific location within the extracellular region and is prevented from moving elsewhere." [GOC:mah]
is_a: GO:0045185 ! maintenance of protein location
relationship: part_of GO:0071692 ! protein localization to extracellular region
created_by: midori
creation_date: 2010-02-25T04:04:41Z

[Term]
id: GO:0071695
name: anatomical structure maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state." [GOC:mah]
is_a: GO:0021700 ! developmental maturation
relationship: part_of GO:0048856 ! anatomical structure development
created_by: midori
creation_date: 2010-03-02T11:43:38Z

[Term]
id: GO:0071696
name: ectodermal placode development
namespace: biological_process
def: "The progression of an ectodermal placode over time from its initial formation until its mature state. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm." [GOC:mah]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
created_by: midori
creation_date: 2010-03-02T11:48:01Z

[Term]
id: GO:0071697
name: ectodermal placode morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of an ectodermal placode are generated and organized. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm." [GOC:mah]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0071696 ! ectodermal placode development
created_by: midori
creation_date: 2010-03-02T11:49:51Z

[Term]
id: GO:0071698
name: olfactory placode development
namespace: biological_process
def: "The progression of the olfactory placode over time from its initial formation until its mature state. The olfactory placode is a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity." [GOC:mah]
is_a: GO:0060429 ! epithelium development
is_a: GO:0071696 ! ectodermal placode development
created_by: midori
creation_date: 2010-03-02T12:45:14Z

[Term]
id: GO:0071699
name: olfactory placode morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the olfactory placode are generated and organized. The olfactory placode is a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity." [GOC:mah]
is_a: GO:0002009 ! morphogenesis of an epithelium
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0071697 ! ectodermal placode morphogenesis
relationship: part_of GO:0071698 ! olfactory placode development
created_by: midori
creation_date: 2010-03-02T12:45:45Z

[Term]
id: GO:0071700
name: olfactory placode maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the olfactory placode to attain its fully functional state. The olfactory placode is a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity." [GOC:mah]
is_a: GO:0071695 ! anatomical structure maturation
relationship: part_of GO:0071698 ! olfactory placode development
created_by: midori
creation_date: 2010-03-02T01:10:54Z

[Term]
id: GO:0071701
name: regulation of MAPK export from nucleus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a MAP kinase from the nucleus to the cytoplasm." [GOC:dgf]
synonym: "regulation of cytoplasmic translocation of MAP kinase" EXACT [GOC:mah]
synonym: "regulation of cytoplasmic translocation of mitogen-activated protein kinase" EXACT [GOC:mah]
synonym: "regulation of MAPK export from cell nucleus" EXACT [GOC:mah]
synonym: "regulation of MAPK export out of nucleus" EXACT [GOC:mah]
synonym: "regulation of MAPK transport from nucleus to cytoplasm" EXACT [GOC:mah]
synonym: "regulation of MAPK-nucleus export" EXACT [GOC:mah]
is_a: GO:0046825 ! regulation of protein export from nucleus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045204 ! MAPK export from nucleus
relationship: regulates GO:0045204 ! MAPK export from nucleus
created_by: midori
creation_date: 2010-03-02T01:24:12Z

[Term]
id: GO:0071702
name: organic substance transport
namespace: biological_process
def: "The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon." [CHEBI:50860, GOC:mah]
is_a: GO:0006810 ! transport
created_by: midori
creation_date: 2010-03-08T02:15:14Z

[Term]
id: GO:0071703
name: detection of organic substance
namespace: biological_process
def: "The series of events in which an organic substance stimulus is received by a cell and converted into a molecular signal." [GOC:mah]
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0010033 ! response to organic substance
created_by: midori
creation_date: 2010-03-08T03:18:44Z

[Term]
id: GO:0071704
name: organic substance metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon." [CHEBI:50860, GOC:mah]
synonym: "organic molecular entity metabolic process" EXACT []
synonym: "organic molecular entity metabolism" EXACT []
synonym: "organic substance metabolism" EXACT []
is_a: GO:0008152 ! metabolic process
created_by: midori
creation_date: 2010-03-08T03:32:18Z

[Term]
id: GO:0071705
name: nitrogen compound transport
namespace: biological_process
def: "The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:51143, GOC:mah]
is_a: GO:0006810 ! transport
created_by: midori
creation_date: 2010-03-08T03:56:28Z

[Term]
id: GO:0071706
name: tumor necrosis factor superfamily cytokine production
namespace: biological_process
def: "The appearance of any member of the TNF superfamily due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add]
synonym: "TNF superfamily production" RELATED [GOC:rv]
synonym: "TNFSF cytokine production" EXACT [GOC:add]
is_a: GO:0001816 ! cytokine production
created_by: midori
creation_date: 2010-03-09T02:40:35Z

[Term]
id: GO:0071707
name: immunoglobulin heavy chain V-D-J recombination
namespace: biological_process
def: "The process in which immunoglobulin heavy chain V, D, and J gene segments are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS)." [GOC:add, ISBN:0781735149]
synonym: "immunoglobulin V(D)J joining" BROAD [GOC:add]
synonym: "immunoglobulin V(D)J recombination" BROAD [GOC:add]
synonym: "immunoglobulin V-D-J joining" EXACT [GOC:add]
is_a: GO:0033152 ! immunoglobulin V(D)J recombination
created_by: midori
creation_date: 2010-03-09T04:20:31Z

[Term]
id: GO:0071708
name: immunoglobulin light chain V-J recombination
namespace: biological_process
def: "The process in which immunoglobulin light chain V and J gene segments are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS)." [GOC:add, ISBN:0781735149]
synonym: "immunoglobulin V(D)J joining" BROAD [GOC:add]
synonym: "immunoglobulin V(D)J recombination" BROAD [GOC:add]
synonym: "immunoglobulin V-J joining" EXACT [GOC:add]
is_a: GO:0033152 ! immunoglobulin V(D)J recombination
created_by: midori
creation_date: 2010-03-09T04:22:29Z

[Term]
id: GO:0071709
name: membrane assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a membrane." [GOC:mah]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0044802 ! single-organism membrane organization
relationship: part_of GO:0044091 ! membrane biogenesis
created_by: midori
creation_date: 2010-03-10T11:19:17Z

[Term]
id: GO:0071710
name: membrane macromolecule biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a macromolecule destined to form part of a membrane in a cell." [GOC:mah]
synonym: "membrane macromolecule anabolism" EXACT [GOC:mah]
synonym: "membrane macromolecule biosynthesis" EXACT [GOC:mah]
synonym: "membrane macromolecule formation" EXACT [GOC:mah]
synonym: "membrane macromolecule synthesis" EXACT [GOC:mah]
is_a: GO:0070589 ! cellular component macromolecule biosynthetic process
relationship: part_of GO:0044091 ! membrane biogenesis
created_by: midori
creation_date: 2010-03-10T11:29:52Z

[Term]
id: GO:0071711
name: basement membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the basement membrane." [GOC:mah]
comment: Note that this term has no relationship to 'membrane organization ; GO:0061024' because the basement membrane is not a lipid bilayer.
synonym: "basement membrane organisation" EXACT [GOC:mah]
is_a: GO:0030198 ! extracellular matrix organization
created_by: midori
creation_date: 2010-03-10T11:57:10Z

[Term]
id: GO:0071712
name: ER-associated misfolded protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of misfolded proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation." [GOC:mah, GOC:vw, PMID:14607247, PMID:19520858]
comment: See also the biological process terms 'unfolded protein response ; GO:0030968' and 'retrograde protein transport, ER to cytosol ; GO:0030970'.
synonym: "endoplasmic reticulum-associated misfolded protein catabolic process" EXACT [GOC:mah]
synonym: "endoplasmic reticulum-associated misfolded protein catabolism" EXACT [GOC:mah]
synonym: "ER-associated misfolded protein breakdown" EXACT [GOC:mah]
synonym: "ER-associated misfolded protein catabolism" EXACT [GOC:mah]
synonym: "ER-associated misfolded protein degradation" EXACT [GOC:mah]
synonym: "proteasomal protein catabolism of misfolded ER proteins" EXACT [GOC:bf]
is_a: GO:0006515 ! misfolded or incompletely synthesized protein catabolic process
is_a: GO:0030433 ! ER-associated ubiquitin-dependent protein catabolic process
is_a: GO:0044712 ! single-organism catabolic process
is_a: GO:0044763 ! single-organism cellular process
relationship: part_of GO:0071218 ! cellular response to misfolded protein
created_by: midori
creation_date: 2010-03-10T12:53:27Z

[Term]
id: GO:0071713
name: para-aminobenzoyl-glutamate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: para-aminobenzoyl-glutamate + H2O = para-aminobenzoate + L-glutamate." [GOC:imk, PMID:20190044]
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
created_by: midori
creation_date: 2010-03-10T01:25:31Z

[Term]
id: GO:0071714
name: icosanoid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of icosanoids from one side of the membrane to the other." [GOC:sl]
synonym: "eicosanoid transmembrane transporter activity" EXACT [GOC:sl]
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:0015245 ! fatty acid transporter activity
relationship: part_of GO:0071715 ! icosanoid transport
created_by: midori
creation_date: 2010-03-10T01:50:08Z

[Term]
id: GO:0071715
name: icosanoid transport
namespace: biological_process
def: "The directed movement of icosanoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Icosanoids are unsaturated C20 fatty acids and skeletally related compounds." [CHEBI:23899, GOC:mah]
synonym: "eicosanoid transport" EXACT [GOC:sl]
is_a: GO:0046942 ! carboxylic acid transport
is_a: GO:1901571 ! fatty acid derivative transport
created_by: midori
creation_date: 2010-03-10T02:47:22Z

[Term]
id: GO:0071716
name: leukotriene transport
namespace: biological_process
def: "The directed movement of leukotrienes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Leukotrienes are linear C20 endogenous metabolites of arachidonic acid (icosa-5,8,11,14-tetraenoic acid) containing a terminal carboxy function and four or more double bonds (three or more of which are conjugated) as well as other functional groups." [CHEBI:25029, GOC:mah]
is_a: GO:0015908 ! fatty acid transport
is_a: GO:0071715 ! icosanoid transport
created_by: midori
creation_date: 2010-03-10T02:53:59Z

[Term]
id: GO:0071717
name: thromboxane transport
namespace: biological_process
def: "The directed movement of thromboxanes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A thromboxane is any of a class of oxygenated oxane derivatives, originally derived from prostaglandin precursors in platelets, that stimulate aggregation of platelets and constriction of blood vessels." [CHEBI:26995, GOC:mah]
is_a: GO:0015908 ! fatty acid transport
is_a: GO:0071715 ! icosanoid transport
created_by: midori
creation_date: 2010-03-10T03:03:49Z

[Term]
id: GO:0071718
name: sodium-independent icosanoid transport
namespace: biological_process
def: "The directed, sodium-independent, movement of icosanoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Icosanoids are unsaturated C20 fatty acids and skeletally related compounds." [CHEBI:23899, GOC:mah, GOC:sl]
synonym: "sodium-independent eicosanoid transport" EXACT [GOC:sl]
is_a: GO:0071715 ! icosanoid transport
created_by: midori
creation_date: 2010-03-10T03:05:13Z

[Term]
id: GO:0071719
name: sodium-independent leukotriene transport
namespace: biological_process
def: "The directed, sodium-independent, movement of leukotrienes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Leukotrienes are linear C20 endogenous metabolites of arachidonic acid (icosa-5,8,11,14-tetraenoic acid) containing a terminal carboxy function and four or more double bonds (three or more of which are conjugated) as well as other functional groups." [CHEBI:25029, GOC:mah]
is_a: GO:0071716 ! leukotriene transport
is_a: GO:0071718 ! sodium-independent icosanoid transport
created_by: midori
creation_date: 2010-03-10T03:08:42Z

[Term]
id: GO:0071720
name: sodium-independent prostaglandin transport
namespace: biological_process
def: "The directed, sodium-independent, movement of prostaglandins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
is_a: GO:0015732 ! prostaglandin transport
is_a: GO:0071718 ! sodium-independent icosanoid transport
created_by: midori
creation_date: 2010-03-10T03:09:10Z

[Term]
id: GO:0071721
name: sodium-independent thromboxane transport
namespace: biological_process
def: "The directed, sodium-independent, movement of thromboxanes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A thromboxane is any of a class of oxygenated oxane derivatives, originally derived from prostaglandin precursors in platelets, that stimulate aggregation of platelets and constriction of blood vessels." [CHEBI:26995, GOC:mah]
is_a: GO:0071717 ! thromboxane transport
is_a: GO:0071718 ! sodium-independent icosanoid transport
created_by: midori
creation_date: 2010-03-10T03:10:45Z

[Term]
id: GO:0071722
name: detoxification of arsenic-containing substance
namespace: biological_process
def: "Any process that reduces or removes the toxicity of compounds containing arsenic, including arsenates, arsenites, and arsenides. These include transport of such compounds away from sensitive areas and to compartments or complexes whose purpose is sequestration of arsenic or arsenic-containing compounds." [GOC:kmv, PMID:11313333, PMID:20221439]
synonym: "detoxification of arsenic" EXACT [GOC:curators]
is_a: GO:0098754 ! detoxification
relationship: part_of GO:0046685 ! response to arsenic-containing substance
created_by: midori
creation_date: 2010-03-17T01:35:56Z

[Term]
id: GO:0071723
name: lipopeptide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a lipopeptide, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds and containing a nonprotein group consisting of a lipid or lipids." [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794]
comment: Note that bacterial lipopeptides are derived from bacterial lipoproteins, but the two terms are sometimes used interchangeably in the literature.
synonym: "bacterial lipopeptide binding" NARROW [GOC:add]
synonym: "bacterial lipoprotein binding" RELATED [GOC:add]
is_a: GO:0008289 ! lipid binding
is_a: GO:0042277 ! peptide binding
created_by: midori
creation_date: 2010-03-17T02:13:21Z

[Term]
id: GO:0071724
name: response to diacyl bacterial lipopeptide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diacylated bacterial lipopeptide stimulus." [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794]
comment: Note that bacterial lipopeptides are derived from bacterial lipoproteins, but the two terms are sometimes used interchangeably in the literature.
synonym: "response to diacylated bacterial lipoprotein" EXACT [GOC:add]
is_a: GO:0070339 ! response to bacterial lipopeptide
created_by: midori
creation_date: 2010-03-17T02:14:41Z

[Term]
id: GO:0071725
name: response to triacyl bacterial lipopeptide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triacylated bacterial lipopeptide stimulus." [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794]
comment: Note that bacterial lipopeptides are derived from bacterial lipoproteins, but the two terms are sometimes used interchangeably in the literature.
synonym: "response to triacylated bacterial lipoprotein" EXACT [GOC:add]
is_a: GO:0070339 ! response to bacterial lipopeptide
created_by: midori
creation_date: 2010-03-17T02:16:40Z

[Term]
id: GO:0071726
name: cellular response to diacyl bacterial lipopeptide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diacylated bacterial lipopeptide stimulus." [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794]
comment: Note that bacterial lipopeptides are derived from bacterial lipoproteins, but the two terms are sometimes used interchangeably in the literature.
synonym: "cellular response to diacylated bacterial lipoprotein" EXACT [GOC:add]
is_a: GO:0071221 ! cellular response to bacterial lipopeptide
is_a: GO:0071724 ! response to diacyl bacterial lipopeptide
created_by: midori
creation_date: 2010-03-17T02:17:02Z

[Term]
id: GO:0071727
name: cellular response to triacyl bacterial lipopeptide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triacylated bacterial lipopeptide stimulus." [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794]
comment: Note that bacterial lipopeptides are derived from bacterial lipoproteins, but the two terms are sometimes used interchangeably in the literature.
synonym: "cellular response to triacylated bacterial lipoprotein" EXACT [GOC:add]
is_a: GO:0071221 ! cellular response to bacterial lipopeptide
is_a: GO:0071725 ! response to triacyl bacterial lipopeptide
created_by: midori
creation_date: 2010-03-17T02:17:49Z

[Term]
id: GO:0071728
name: beak development
namespace: biological_process
def: "The progression of the beak over time from its initial formation until its mature state. The avian beak is an external anatomical structure, in the head region, that is adapted for feeding self and young, catching prey, probing, etc. It encompasses, but is not restricted to, the maxilla, mandible, maxillary rhamphotheca, mandibular rhamphotheca, nostril, nasal fossa, nasal bones, egg tooth and rictus." [GOC:lp, ISBN:0702008729]
comment: This term was added by GO_REF:0000021.
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
created_by: midori
creation_date: 2010-03-17T03:52:48Z

[Term]
id: GO:0071729
name: beak morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the beak are generated and organized. The avian beak is an external anatomical structure, in the head region, that is adapted for feeding self and young, catching prey, probing, etc. It encompasses, but is not restricted to, the maxilla, mandible, maxillary rhamphotheca, mandibular rhamphotheca, nostril, nasal fossa, nasal bones, egg tooth and rictus." [GOC:lp, ISBN:0702008729]
comment: This term was added by GO_REF:0000021.
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0071728 ! beak development
created_by: midori
creation_date: 2010-03-17T03:54:34Z

[Term]
id: GO:0071730
name: beak formation
namespace: biological_process
def: "The process that gives rise to the beak. This process pertains to the initial formation of a structure from unspecified parts. The avian beak is an external anatomical structure, in the head region, that is adapted for feeding self and young, catching prey, probing, etc. It encompasses, but is not restricted to, the maxilla, mandible, maxillary rhamphotheca, mandibular rhamphotheca, nostril, nasal fossa, nasal bones, egg tooth and rictus." [GOC:lp, ISBN:0702008729]
comment: This term was added by GO_REF:0000021.
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0071729 ! beak morphogenesis
created_by: midori
creation_date: 2010-03-17T03:57:07Z

[Term]
id: GO:0071731
name: response to nitric oxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus." [GOC:mah, GOC:yaf]
is_a: GO:0000302 ! response to reactive oxygen species
is_a: GO:0010035 ! response to inorganic substance
is_a: GO:1901698 ! response to nitrogen compound
created_by: midori
creation_date: 2010-03-17T04:03:38Z

[Term]
id: GO:0071732
name: cellular response to nitric oxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus." [GOC:mah, GOC:yaf]
is_a: GO:0034614 ! cellular response to reactive oxygen species
is_a: GO:0071241 ! cellular response to inorganic substance
is_a: GO:0071731 ! response to nitric oxide
is_a: GO:1902170 ! cellular response to reactive nitrogen species
created_by: midori
creation_date: 2010-03-17T04:12:52Z

[Term]
id: GO:0071733
name: transcriptional activation by promoter-enhancer looping
namespace: biological_process
def: "The formation and maintenance of DNA loops that juxtapose the promoter and enhancer regions of RNA polymerase II-transcribed genes and activate transcription from an RNA polymerase II promoter." [GOC:mah, PMID:15060134, PMID:19923429]
synonym: "long-range enhancer-promoter communication" RELATED [PMID:15060134]
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
is_a: GO:0090202 ! gene looping
created_by: midori
creation_date: 2010-03-19T02:01:19Z

[Term]
id: GO:0071734
name: biotin-[pyruvate-carboxylase] ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + biotin + apo-(pyruvate-carboxylase) = AMP + diphosphate + biotin-(pyruvate-carboxylase)." [GOC:mah, PMID:10551847]
synonym: "biotin-[pyruvate carboxylase] ligase activity" EXACT [GOC:jp]
synonym: "biotin-[pyruvate carboxylase] synthetase activity" EXACT [GOC:mah]
synonym: "biotin-pyruvate carboxylase synthetase activity" EXACT [GOC:mah]
synonym: "biotin-pyruvate-carboxylase ligase activity" EXACT [GOC:mah]
synonym: "biotin:apo-pyruvate-carboxylase ligase" EXACT [GOC:mah]
xref: EC:6.3.4.-
is_a: GO:0018271 ! biotin-protein ligase activity
created_by: midori
creation_date: 2010-03-19T02:37:24Z

[Term]
id: GO:0071735
name: IgG immunoglobulin complex
namespace: cellular_component
def: "A protein complex composed of two identical immunoglobulin heavy chains of an IgG isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgG immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196]
comment: Note that an IgG immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Also, IgG isotypes vary by species.
synonym: "IgG1" NARROW [GOC:add]
synonym: "IgG2" NARROW [GOC:add]
synonym: "IgG2a" NARROW [GOC:add]
synonym: "IgG2b" NARROW [GOC:add]
synonym: "IgG2c" NARROW [GOC:add]
synonym: "IgG3" NARROW [GOC:add]
synonym: "IgG4" NARROW [GOC:add]
is_a: GO:0019814 ! immunoglobulin complex
created_by: midori
creation_date: 2010-03-24T01:44:53Z

[Term]
id: GO:0071736
name: IgG immunoglobulin complex, circulating
namespace: cellular_component
def: "A protein complex composed of two identical immunoglobulin heavy chains of an IgG isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196]
comment: Note that an IgG immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Also, IgG isotypes vary by species.
synonym: "IgG antibody" NARROW [GOC:add]
synonym: "IgG1 antibody" NARROW [GOC:add]
synonym: "IgG2 antibody" NARROW [GOC:add]
synonym: "IgG2a antibody" NARROW [GOC:add]
synonym: "IgG2b antibody" NARROW [GOC:add]
synonym: "IgG2c antibody" NARROW [GOC:add]
synonym: "IgG3 antibody" NARROW [GOC:add]
synonym: "IgG4 antibody" NARROW [GOC:add]
is_a: GO:0042571 ! immunoglobulin complex, circulating
is_a: GO:0071735 ! IgG immunoglobulin complex
created_by: midori
creation_date: 2010-03-24T01:44:53Z

[Term]
id: GO:0071737
name: IgG B cell receptor complex
namespace: cellular_component
def: "An IgG immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of an IgG isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [GOC:add, ISBN:0781765196]
comment: Note that an IgG immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Also, IgG isotypes vary by species.
synonym: "membrane-bound IgG" NARROW [GOC:add]
synonym: "membrane-bound IgG1" NARROW [GOC:add]
synonym: "membrane-bound IgG2" NARROW [GOC:add]
synonym: "membrane-bound IgG2a" NARROW [GOC:add]
synonym: "membrane-bound IgG2b" NARROW [GOC:add]
synonym: "membrane-bound IgG2c" NARROW [GOC:add]
synonym: "membrane-bound IgG3" NARROW [GOC:add]
synonym: "membrane-bound IgG4" NARROW [GOC:add]
synonym: "surface IgG" NARROW [GOC:add]
synonym: "surface IgG1" NARROW [GOC:add]
synonym: "surface IgG2" NARROW [GOC:add]
synonym: "surface IgG2a" NARROW [GOC:add]
synonym: "surface IgG2b" NARROW [GOC:add]
synonym: "surface IgG2c" NARROW [GOC:add]
synonym: "surface IgG3" NARROW [GOC:add]
synonym: "surface IgG4" NARROW [GOC:add]
is_a: GO:0019815 ! B cell receptor complex
is_a: GO:0071735 ! IgG immunoglobulin complex
created_by: midori
creation_date: 2010-03-24T01:44:53Z

[Term]
id: GO:0071738
name: IgD immunoglobulin complex
namespace: cellular_component
def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgD immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:11282392]
comment: Note that an IgD immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
is_a: GO:0019814 ! immunoglobulin complex
created_by: midori
creation_date: 2010-03-24T01:44:53Z

[Term]
id: GO:0071739
name: IgD immunoglobulin complex, circulating
namespace: cellular_component
def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:11282392]
comment: Note that an IgD immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
synonym: "IgD antibody" EXACT [GOC:add]
is_a: GO:0042571 ! immunoglobulin complex, circulating
is_a: GO:0071738 ! IgD immunoglobulin complex
created_by: midori
creation_date: 2010-03-24T01:44:53Z

[Term]
id: GO:0071740
name: IgD B cell receptor complex
namespace: cellular_component
def: "An IgD immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [GOC:add, ISBN:0781765196, PMID:11282392]
comment: Note that an IgD immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
synonym: "membrane-bound IgD" EXACT [GOC:add]
synonym: "surface IgD" EXACT [GOC:add]
is_a: GO:0019815 ! B cell receptor complex
is_a: GO:0071738 ! IgD immunoglobulin complex
created_by: midori
creation_date: 2010-03-24T01:44:53Z

[Term]
id: GO:0071741
name: IgD immunoglobulin complex, GPI-anchored
namespace: cellular_component
def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and bound via a GPI-anchor to the plasma membrane of B cells." [GOC:add, ISBN:0781765196, PMID:11282392]
comment: Note that an IgD immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
synonym: "GPI-anchored IgD" EXACT [GOC:add]
is_a: GO:0071738 ! IgD immunoglobulin complex
created_by: midori
creation_date: 2010-03-24T01:44:53Z

[Term]
id: GO:0071742
name: IgE immunoglobulin complex
namespace: cellular_component
def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgE isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgE immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196]
comment: Note that an IgE immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
is_a: GO:0019814 ! immunoglobulin complex
created_by: midori
creation_date: 2010-03-24T01:44:53Z

[Term]
id: GO:0071743
name: IgE immunoglobulin complex, circulating
namespace: cellular_component
def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgE isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196]
comment: Note that an IgE immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
synonym: "IgE antibody" EXACT [GOC:add]
is_a: GO:0042571 ! immunoglobulin complex, circulating
is_a: GO:0071742 ! IgE immunoglobulin complex
created_by: midori
creation_date: 2010-03-24T01:44:53Z

[Term]
id: GO:0071744
name: IgE B cell receptor complex
namespace: cellular_component
def: "An IgE immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of the IgE isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [GOC:add, ISBN:0781765196]
comment: Note that an IgE immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
synonym: "membrane-bound IgE" EXACT [GOC:add]
synonym: "surface IgE" EXACT [GOC:add]
is_a: GO:0019815 ! B cell receptor complex
is_a: GO:0071742 ! IgE immunoglobulin complex
created_by: midori
creation_date: 2010-03-24T01:44:53Z

[Term]
id: GO:0071745
name: IgA immunoglobulin complex
namespace: cellular_component
def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and sometimes complexed with J chain or J chain and secretory component. An IgA immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:16362985]
comment: Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
synonym: "IgA1 antibody" NARROW [GOC:add]
synonym: "IgA2 antibody" NARROW [GOC:add]
is_a: GO:0019814 ! immunoglobulin complex
created_by: midori
creation_date: 2010-03-24T01:44:53Z

[Term]
id: GO:0071746
name: IgA immunoglobulin complex, circulating
namespace: cellular_component
def: "A protein complex composed of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds, sometimes complexed with J chain or J chain and secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:16362985]
comment: Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
synonym: "IgA antibody" EXACT [GOC:add]
synonym: "IgA1 antibody" NARROW [GOC:add]
synonym: "IgA2 antibody" NARROW [GOC:add]
is_a: GO:0042571 ! immunoglobulin complex, circulating
is_a: GO:0071745 ! IgA immunoglobulin complex
created_by: midori
creation_date: 2010-03-24T01:44:53Z

[Term]
id: GO:0071747
name: IgA B cell receptor complex
namespace: cellular_component
def: "An IgA immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [GOC:add, ISBN:0781765196, PMID:16362985]
comment: Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
synonym: "membrane-bound IgA" NARROW [GOC:add]
synonym: "membrane-bound IgA1" NARROW [GOC:add]
synonym: "membrane-bound IgA2" NARROW [GOC:add]
synonym: "surface IgA" NARROW [GOC:add]
synonym: "surface IgA1" NARROW [GOC:add]
synonym: "surface IgA2" NARROW [GOC:add]
is_a: GO:0019815 ! B cell receptor complex
is_a: GO:0071745 ! IgA immunoglobulin complex
created_by: midori
creation_date: 2010-03-24T01:44:53Z

[Term]
id: GO:0071748
name: monomeric IgA immunoglobulin complex
namespace: cellular_component
def: "A protein complex composed of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:16362985]
comment: Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
synonym: "monomeric IgA antibody" EXACT [GOC:add]
synonym: "monomeric IgA1 antibody" NARROW [GOC:add]
synonym: "monomeric IgA2 antibody" NARROW [GOC:add]
is_a: GO:0071746 ! IgA immunoglobulin complex, circulating
created_by: midori
creation_date: 2010-03-24T01:44:53Z

[Term]
id: GO:0071749
name: polymeric IgA immunoglobulin complex
namespace: cellular_component
def: "A protein complex composed of two, three, or four monomeric IgA immunoglobulin complexes linked through both direct disulfide bonds and through disulfide binded monomers of J chain acting as a bridge. Each IgA monomer consists of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds. Dimeric IgA is sometimes complexed additionally with secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:16362985]
comment: Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Dimeric IgA is by far the most common form of polymeric IgA. In human only the IgA1 isotype is capable of a polymeric forms.
synonym: "pIgA antibody" EXACT [GOC:add]
synonym: "pIgA1 antibody" NARROW [GOC:add]
synonym: "polymeric IgA antibody" EXACT [GOC:add]
synonym: "polymeric IgA1 antibody" NARROW [GOC:add]
is_a: GO:0071746 ! IgA immunoglobulin complex, circulating
created_by: midori
creation_date: 2010-03-24T01:44:53Z

[Term]
id: GO:0071750
name: dimeric IgA immunoglobulin complex
namespace: cellular_component
def: "A protein complex composed of two monomeric IgA immunoglobulin complexes linked through both direct disulfide bonds and through a disulfide binded monomer of J chain acting as a bridge. Each IgA monomer consists of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds. Dimeric IgA is sometimes complexed additionally with secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:16362985]
comment: Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Dimeric IgA is by far the most common form of polymeric IgA. In human only the IgA1 isotype is capable of a dimeric form.
synonym: "dimeric IgA antibody" EXACT [GOC:add]
synonym: "dimeric IgA1 antibody" NARROW [GOC:add]
is_a: GO:0071749 ! polymeric IgA immunoglobulin complex
created_by: midori
creation_date: 2010-03-24T01:44:53Z

[Term]
id: GO:0071751
name: secretory IgA immunoglobulin complex
namespace: cellular_component
def: "A polymeric IgA immunoglobulin complex that is complexed with one chain of secretory component (SC). Polymeric IgA is present in mucosal areas, having been transported via a transcytosis mechanism in mucosal epithelial cells relying on the polymeric Ig receptor, a portion of which then remains bound to the polymeric IgA as secretory component." [GOC:add, ISBN:0781765196, PMID:16362985]
comment: Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available. In human only the IgA1 isotype in the polymeric form is capable of becoming secretory IgA.
synonym: "secretory IgA antibody" EXACT [GOC:add]
synonym: "sIgA antibody" EXACT [GOC:add]
synonym: "sIgA1 antibody" NARROW [GOC:add]
is_a: GO:0071749 ! polymeric IgA immunoglobulin complex
created_by: midori
creation_date: 2010-03-24T01:44:53Z

[Term]
id: GO:0071752
name: secretory dimeric IgA immunoglobulin complex
namespace: cellular_component
def: "A dimeric form of secretory IgA immunoglobulin complex." [GOC:add, ISBN:0781765196, PMID:16362985]
comment: Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Dimeric IgA is by far the most common form of polymeric IgA. In human only the IgA1 isotype is capable of a dimeric form.
synonym: "secretory dimeric IgA antibody" EXACT [GOC:add]
synonym: "secretory dimeric IgA1 antibody" NARROW [GOC:add]
is_a: GO:0071750 ! dimeric IgA immunoglobulin complex
is_a: GO:0071751 ! secretory IgA immunoglobulin complex
created_by: midori
creation_date: 2010-03-24T01:44:53Z

[Term]
id: GO:0071753
name: IgM immunoglobulin complex
namespace: cellular_component
def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgM isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and in its circulating form complexed with J chain in polymeric forms. An IgM immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:20176268]
comment: Note that an IgM immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
is_a: GO:0019814 ! immunoglobulin complex
created_by: midori
creation_date: 2010-03-24T01:44:53Z

[Term]
id: GO:0071754
name: IgM immunoglobulin complex, circulating
namespace: cellular_component
def: "A polymer of five or six IgM core units each composed of two identical immunoglobulin heavy chains of the IgM isotype and two identical immunoglobulin light chains, held together by disulfide bonds; the individual IgM core units are held together via disulfide bonds with a single J chain polypeptide acting as a bridge between two of the polymeric units. Circulating IgM is present in the extracellular space, in mucosal areas or other tissues, or in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:20176268]
comment: Note that an IgM immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
synonym: "IgM antibody" EXACT [GOC:add]
is_a: GO:0042571 ! immunoglobulin complex, circulating
is_a: GO:0071753 ! IgM immunoglobulin complex
created_by: midori
creation_date: 2010-03-24T01:44:53Z

[Term]
id: GO:0071755
name: IgM B cell receptor complex
namespace: cellular_component
def: "An IgM immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of the IgM isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [GOC:add, ISBN:0781765196, PMID:20176268]
comment: Note that an IgM immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
synonym: "membrane-bound IgM" NARROW [GOC:add]
synonym: "surface IgM" NARROW [GOC:add]
is_a: GO:0019815 ! B cell receptor complex
is_a: GO:0071753 ! IgM immunoglobulin complex
created_by: midori
creation_date: 2010-03-24T01:44:53Z

[Term]
id: GO:0071756
name: pentameric IgM immunoglobulin complex
namespace: cellular_component
def: "A circulating form of IgM consisting of a pentamer of IgM core units with a single J chain polypeptide." [GOC:add, ISBN:0781765196, PMID:20176268]
comment: Note that an IgM immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
synonym: "pentameric IgM antibody" EXACT [GOC:add]
is_a: GO:0071754 ! IgM immunoglobulin complex, circulating
created_by: midori
creation_date: 2010-03-24T01:44:53Z

[Term]
id: GO:0071757
name: hexameric IgM immunoglobulin complex
namespace: cellular_component
def: "A circulating form of IgM consisting of a hexamer of IgM core units with a single J chain polypeptide." [GOC:add, ISBN:0781765196, PMID:20176268]
comment: Note that an IgM immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
synonym: "hexameric IgM antibody" EXACT [GOC:add]
is_a: GO:0071754 ! IgM immunoglobulin complex, circulating
created_by: midori
creation_date: 2010-03-24T01:44:53Z

[Term]
id: GO:0071758
name: IgW immunoglobulin complex
namespace: cellular_component
def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgW isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgW immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196]
comment: Note that an IgW immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Note that IgW is found in fish.
is_a: GO:0019814 ! immunoglobulin complex
created_by: midori
creation_date: 2010-03-24T01:44:53Z

[Term]
id: GO:0071759
name: IgX immunoglobulin complex
namespace: cellular_component
def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgX isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgX immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196]
comment: Note that an IgX immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Note that IgX is found in amphibians.
is_a: GO:0019814 ! immunoglobulin complex
created_by: midori
creation_date: 2010-03-24T01:44:53Z

[Term]
id: GO:0071760
name: IgY immunoglobulin complex
namespace: cellular_component
def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgY isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgY immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196]
comment: Note that an IgY immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Note that IgY is found in amphibians, reptiles, and birds.
is_a: GO:0019814 ! immunoglobulin complex
created_by: midori
creation_date: 2010-03-24T01:44:53Z

[Term]
id: GO:0071761
name: IgZ immunoglobulin complex
namespace: cellular_component
def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgZ isotype and two identical immunoglobulin light chains, held together by disulfide bonds. The IgZ isotype is also known as the IgT isotype in certain species of fish." [GOC:add, ISBN:0781765196]
comment: Note that an IgZ immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Note that IgZ is found in bony fish, and called IgT in certain species, such as trout.
synonym: "IgT antibody" NARROW [GOC:add]
synonym: "IgT immunoglobulin complex" EXACT [ISBN:0781765196]
synonym: "IgZ antibody" NARROW [GOC:add]
is_a: GO:0019814 ! immunoglobulin complex
created_by: midori
creation_date: 2010-03-24T01:44:53Z

[Term]
id: GO:0071762
name: heavy chain immunoglobulin complex
namespace: cellular_component
def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgNAR isotype held together by disulfide bonds and lacking immunoglobulin light chains." [GOC:add, ISBN:0781765196, PMID:12543123, PMID:16051357]
comment: Note that a heavy chain immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Note that IgNAR is found in serum of cartilaginous fish as a heavy chain dimer without immunoglobulin light chains. Note that HCab is found in camels as a heavy chain dimer without immunoglobulin light chains.
synonym: "HCab" NARROW [GOC:add]
synonym: "Ig NAR immunoglobulin complex" NARROW [GOC:add]
synonym: "IgNAR antibody" NARROW [GOC:add]
synonym: "IgNAR immunoglobulin complex" NARROW [GOC:add]
is_a: GO:0019814 ! immunoglobulin complex
created_by: midori
creation_date: 2010-03-24T01:44:53Z

[Term]
id: GO:0071763
name: nuclear membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner or outer membrane." [GOC:mah]
synonym: "nuclear membrane organisation" EXACT [GOC:mah]
synonym: "nuclear membrane organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0044802 ! single-organism membrane organization
relationship: part_of GO:0006998 ! nuclear envelope organization
created_by: midori
creation_date: 2010-03-29T03:59:35Z

[Term]
id: GO:0071764
name: nuclear outer membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear outer membrane." [GOC:mah]
synonym: "nuclear outer membrane organisation" EXACT [GOC:mah]
synonym: "nuclear outer membrane organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0071763 ! nuclear membrane organization
relationship: part_of GO:0010256 ! endomembrane system organization
created_by: midori
creation_date: 2010-03-29T04:03:37Z

[Term]
id: GO:0071765
name: nuclear inner membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner membrane." [GOC:mah]
synonym: "nuclear inner membrane organisation" EXACT [GOC:mah]
synonym: "nuclear inner membrane organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0071763 ! nuclear membrane organization
created_by: midori
creation_date: 2010-03-29T04:04:57Z

[Term]
id: GO:0071766
name: Actinobacterium-type cell wall biogenesis
namespace: biological_process
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cell wall of the type found in Actinobacteria. The cell wall is the rigid or semi-rigid envelope lying outside the cell membrane. Actinobacterial cell walls contain characteristic mycolic acids, of which some are covalently linked to the cell wall peptidoglycan and others accumulate at the cell surface." [GOC:mah, PMID:15653820, PMID:3149973]
subset: gosubset_prok
is_a: GO:0009273 ! peptidoglycan-based cell wall biogenesis
created_by: midori
creation_date: 2010-03-29T04:12:51Z

[Term]
id: GO:0071767
name: mycolic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mycolic acids, beta-hydroxy fatty acids with a long alpha-alkyl side chain." [GOC:mah, PMID:15653820]
synonym: "mycolate metabolic process" EXACT [GOC:mah]
synonym: "mycolic acid metabolism" EXACT [GOC:mah]
is_a: GO:0006631 ! fatty acid metabolic process
created_by: midori
creation_date: 2010-03-29T04:33:31Z

[Term]
id: GO:0071768
name: mycolic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of mycolic acids, beta-hydroxy fatty acids with a long alpha-alkyl side chain." [GOC:mah, MetaCyc:PWYG-321, PMID:15653820]
synonym: "mycolate biosynthetic process" EXACT [GOC:mah]
synonym: "mycolic acid anabolism" EXACT [GOC:mah]
synonym: "mycolic acid biosynthesis" EXACT [GOC:mah]
synonym: "mycolic acid formation" EXACT [GOC:mah]
synonym: "mycolic acid synthesis" EXACT [GOC:mah]
xref: MetaCyc:PWYG-321
is_a: GO:0006633 ! fatty acid biosynthetic process
is_a: GO:0044038 ! cell wall macromolecule biosynthetic process
is_a: GO:0071767 ! mycolic acid metabolic process
relationship: part_of GO:0071766 ! Actinobacterium-type cell wall biogenesis
created_by: midori
creation_date: 2010-03-29T04:36:10Z

[Term]
id: GO:0071769
name: mycolate cell wall layer assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components, including arabinogalactan mycolate and trehalose dimycolate, to form the mycolate layer of the Actinobacterium-type cell wall. The mycolate layer is physically attached to the peptidoglycan layer." [GOC:mah, MetaCyc:PWY-6397, PMID:15653820, PMID:3149973]
synonym: "mycolate cell wall layer biogenesis" RELATED [GOC:mah]
xref: MetaCyc:PWY-6397
is_a: GO:0022607 ! cellular component assembly
relationship: part_of GO:0071766 ! Actinobacterium-type cell wall biogenesis
created_by: midori
creation_date: 2010-03-29T04:40:45Z

[Term]
id: GO:0071770
name: DIM/DIP cell wall layer assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components, including (phenyl)phthiocerol, phthiodiolone, phthiotriol dimycocerosate and diphthioceranate, to form the DIM/DIP layer of the Actinobacterium-type cell wall." [GOC:mah, PMID:15653820, PMID:3149973]
synonym: "DIM cell wall layer assembly" EXACT [GOC:mah]
synonym: "DIM/DIP cell wall layer biogenesis" RELATED [GOC:mah]
synonym: "PDIM cell wall layer assembly" EXACT [GOC:mah]
is_a: GO:0022607 ! cellular component assembly
relationship: part_of GO:0071766 ! Actinobacterium-type cell wall biogenesis
created_by: midori
creation_date: 2010-03-29T04:47:19Z

[Term]
id: GO:0071771
name: aldehyde decarbonylase activity
namespace: molecular_function
def: "Catalysis of the reaction: a C(n) aldehyde = C(n-1) alkane + CO." [GOC:kad, PMID:6593720, PMID:8718622]
synonym: "decarbonylase activity" EXACT [EC:4.1.99.5, GOC:kad, GOC:mah]
xref: EC:4.1.99.-
is_a: GO:0016830 ! carbon-carbon lyase activity
created_by: midori
creation_date: 2010-04-01T12:02:50Z

[Term]
id: GO:0071772
name: response to BMP
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus." [GOC:mah, GOC:yaf]
synonym: "response to BMP stimulus" EXACT [GOC:dos]
synonym: "response to bone morphogenetic protein stimulus" EXACT [GOC:mah]
is_a: GO:0009719 ! response to endogenous stimulus
is_a: GO:0070848 ! response to growth factor
created_by: midori
creation_date: 2010-08-31T11:02:11Z

[Term]
id: GO:0071773
name: cellular response to BMP stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus." [GOC:mah, GOC:yaf]
synonym: "cellular response to bone morphogenetic protein stimulus" EXACT [GOC:mah]
is_a: GO:0071363 ! cellular response to growth factor stimulus
is_a: GO:0071495 ! cellular response to endogenous stimulus
is_a: GO:0071772 ! response to BMP
created_by: midori
creation_date: 2010-08-31T11:04:45Z

[Term]
id: GO:0071774
name: response to fibroblast growth factor
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fibroblast growth factor stimulus." [GOC:mah]
synonym: "response to FGF stimulus" EXACT [GOC:mah]
synonym: "response to fibroblast growth factor stimulus" EXACT [GOC:dos]
is_a: GO:0009719 ! response to endogenous stimulus
is_a: GO:0070848 ! response to growth factor
created_by: midori
creation_date: 2010-08-31T11:06:32Z

[Term]
id: GO:0071778
name: obsolete WINAC complex
namespace: cellular_component
def: "OBSOLETE. A SWI/SNF-type complex that directly interacts with the vitamin D receptor (VDR) through the Williams syndrome transcription factor (WSTF), and mediates the recruitment of unliganded VDR to VDR target sites in promoters. The WINAC complex contains at least 13 subunits, including WSTF, several SWI/SNF components, and DNA replication-related factors." [GOC:BHF, PMID:12837248]
comment: This term was made obsolete because the paper describing the characterization of this complex, which was used to create this term, has been retracted.
synonym: "WINAC complex" EXACT []
is_obsolete: true
created_by: midori
creation_date: 2010-08-31T12:19:54Z

[Term]
id: GO:0071781
name: endoplasmic reticulum cisternal network
namespace: cellular_component
def: "A subcompartment of the endoplasmic reticulum consisting of flattened, disc-shaped domains known as cisternae.  These are typically found close to the nucleus and are generally more prominent in secretory cells." [GOC:vw, PMID:16469703, PMID:20434336]
synonym: "ER cisternal network" EXACT [GOC:mah]
is_a: GO:0098827 ! endoplasmic reticulum subcompartment
relationship: part_of GO:0005783 ! endoplasmic reticulum
created_by: midori
creation_date: 2010-09-01T01:29:54Z

[Term]
id: GO:0071782
name: endoplasmic reticulum tubular network
namespace: cellular_component
def: "A subcompartment of the endoplasmic reticulum consisting of tubules having membranes with high curvature in cross-section." [GOC:vw, PMID:16469703, PMID:20434336]
synonym: "ER tubular network" EXACT [GOC:mah]
is_a: GO:0098827 ! endoplasmic reticulum subcompartment
relationship: part_of GO:0005783 ! endoplasmic reticulum
created_by: midori
creation_date: 2010-09-01T01:32:55Z

[Term]
id: GO:0071783
name: endoplasmic reticulum cisternal network organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER) cisternal network. The ER cisternal network is the ER part that comprises the membranes with low curvature in cross-section." [GOC:vw, PMID:16469703, PMID:20434336]
synonym: "endoplasmic reticulum cisternal network organisation" EXACT [GOC:mah]
synonym: "ER cisternal network organisation" EXACT [GOC:mah]
synonym: "ER cisternal network organization" EXACT [GOC:mah]
is_a: GO:0007029 ! endoplasmic reticulum organization
created_by: midori
creation_date: 2010-09-01T01:47:28Z

[Term]
id: GO:0071784
name: endoplasmic reticulum cisternal network assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the endoplasmic reticulum (ER) cisternal network. The ER cisternal network is the ER part that comprises the membranes with low curvature in cross-section." [GOC:mah, PMID:16469703, PMID:20434336]
synonym: "endoplasmic reticulum cisternal network formation" EXACT [GOC:mah]
synonym: "ER cisternal network assembly" EXACT [GOC:mah]
synonym: "ER cisternal network formation" EXACT [GOC:mah]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0071783 ! endoplasmic reticulum cisternal network organization
created_by: midori
creation_date: 2010-09-01T01:50:49Z

[Term]
id: GO:0071785
name: endoplasmic reticulum cisternal network maintenance
namespace: biological_process
def: "The organization process that preserves the endoplasmic reticulum (ER) cisternal network in a stable functional or structural state. The ER cisternal network is the ER part that comprises the membranes with low curvature in cross-section." [GOC:mah, PMID:16469703, PMID:20434336]
synonym: "ER cisternal network maintenance" EXACT [GOC:mah]
is_a: GO:0043954 ! cellular component maintenance
is_a: GO:0071783 ! endoplasmic reticulum cisternal network organization
is_a: GO:1902589 ! single-organism organelle organization
created_by: midori
creation_date: 2010-09-01T01:52:26Z

[Term]
id: GO:0071786
name: endoplasmic reticulum tubular network organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER) tubular network. The ER tubular network is the ER part that that has membranes with high curvature in cross-section." [GOC:vw, PMID:16469703, PMID:20434336]
synonym: "endoplasmic reticulum tubular network organisation" EXACT [GOC:mah]
synonym: "ER tubular network organisation" EXACT [GOC:mah]
synonym: "ER tubular network organization" EXACT [GOC:mah]
is_a: GO:0007029 ! endoplasmic reticulum organization
created_by: midori
creation_date: 2010-09-01T01:53:51Z

[Term]
id: GO:0071787
name: endoplasmic reticulum tubular network assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the endoplasmic reticulum (ER) tubular network. The ER tubular network is the ER part that comprises the membranes with high curvature in cross-section." [GOC:mah, PMID:16469703, PMID:20434336]
synonym: "endoplasmic reticulum tubular network formation" EXACT [GOC:mah]
synonym: "ER tubular network assembly" EXACT [GOC:mah]
synonym: "ER tubular network formation" EXACT [GOC:mah]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0071786 ! endoplasmic reticulum tubular network organization
created_by: midori
creation_date: 2010-09-01T01:54:29Z

[Term]
id: GO:0071788
name: endoplasmic reticulum tubular network maintenance
namespace: biological_process
def: "The organization process that preserves the endoplasmic reticulum (ER) tubular network in a stable functional or structural state. The ER tubular network is the ER part that comprises the membranes with high curvature in cross-section." [GOC:mah, PMID:16469703, PMID:20434336]
synonym: "ER tubular network maintenance" EXACT [GOC:mah]
is_a: GO:0043954 ! cellular component maintenance
is_a: GO:0071786 ! endoplasmic reticulum tubular network organization
is_a: GO:1902589 ! single-organism organelle organization
created_by: midori
creation_date: 2010-09-01T01:55:06Z

[Term]
id: GO:0071789
name: spindle pole body localization to nuclear envelope
namespace: biological_process
def: "A process in which a spindle pole body is transported to, or maintained in, a specific location in the nuclear envelope. A spindle pole body is a type of microtubule organizing center found in fungal cells." [GOC:mah, PMID:20434336]
synonym: "spindle pole body anchorage" EXACT [GOC:vw]
synonym: "spindle pole body docking" EXACT [GOC:vw]
synonym: "spindle pole body localisation in nuclear envelope" EXACT [GOC:mah]
synonym: "spindle pole body localization in nuclear envelope" EXACT [GOC:curators]
is_a: GO:0070631 ! spindle pole body localization
created_by: midori
creation_date: 2010-09-01T02:22:44Z

[Term]
id: GO:0071790
name: establishment of spindle pole body localization to nuclear envelope
namespace: biological_process
def: "A process in which a spindle pole body is transported to a specific location in the nuclear envelope. A spindle pole body is a type of microtubule organizing center found in fungal cells." [GOC:mah, PMID:20434336]
synonym: "establishment of spindle pole body localisation in nuclear envelope" EXACT [GOC:mah]
synonym: "establishment of spindle pole body localization in nuclear envelope" EXACT [GOC:curators]
is_a: GO:0070632 ! establishment of spindle pole body localization
is_a: GO:0071789 ! spindle pole body localization to nuclear envelope
created_by: midori
creation_date: 2010-09-01T02:25:44Z

[Term]
id: GO:0071791
name: chemokine (C-C motif) ligand 5 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with chemokine (C-C motif) ligand 5." [GOC:add, GOC:amm]
synonym: "CCL5 binding" EXACT [GOC:add, GOC:amm]
synonym: "RANTES binding" EXACT [GOC:bf]
synonym: "Regulated upon Activation, Normal T-cell Expressed, and Secreted binding" EXACT [GOC:add]
is_a: GO:0019957 ! C-C chemokine binding
created_by: midori
creation_date: 2010-09-01T02:28:22Z

[Term]
id: GO:0071792
name: bacillithiol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving bacillithiol, the alpha-anomeric glycoside of L-cysteinyl-D-glucosamine with L-malic acid. Bacillithiol, produced widely in the Firmicutes and sporadically in other bacterial lineages, is a low-molecular-weight thiol analogous to mycothiol in the Actinomycetes and glutathione in many species." [GOC:dh, PMID:20308541]
subset: gosubset_prok
synonym: "bacillithiol metabolism" EXACT [GOC:mah]
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0016137 ! glycoside metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process
is_a: GO:0051186 ! cofactor metabolic process
created_by: midori
creation_date: 2010-09-02T11:13:47Z

[Term]
id: GO:0071793
name: bacillithiol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of bacillithiol, the alpha-anomeric glycoside of L-cysteinyl-D-glucosamine with L-malic acid. Bacillithiol, produced widely in the Firmicutes and sporadically in other bacterial lineages, is a low-molecular-weight thiol analogous to mycothiol in the Actinomycetes and glutathione in many species." [GOC:dh, PMID:20308541]
subset: gosubset_prok
synonym: "bacillithiol anabolism" EXACT [GOC:mah]
synonym: "bacillithiol biosynthesis" EXACT [GOC:mah]
synonym: "bacillithiol formation" EXACT [GOC:mah]
synonym: "bacillithiol synthesis" EXACT [GOC:mah]
is_a: GO:0016138 ! glycoside biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
is_a: GO:0051188 ! cofactor biosynthetic process
is_a: GO:0071792 ! bacillithiol metabolic process
created_by: midori
creation_date: 2010-09-02T11:16:04Z

[Term]
id: GO:0071794
name: CAP-Gly domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a CAP-Gly domain of a protein. The CAP_Gly domain is a conserved, glycine-rich domain of about 42 residues found in some cytoskeleton-associated proteins, and features a novel protein fold containing three beta-sheets." [GOC:mah, InterPro:IPR000938]
is_a: GO:0019904 ! protein domain specific binding
created_by: midori
creation_date: 2010-09-02T02:02:53Z

[Term]
id: GO:0071795
name: K11-linked polyubiquitin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently and non-covalently with a polymer of ubiquitin formed by linkages between lysine residues at position 11 of the ubiquitin monomers." [GOC:sp, PMID:18775313]
is_a: GO:0031593 ! polyubiquitin binding
created_by: midori
creation_date: 2010-09-02T02:11:41Z

[Term]
id: GO:0071796
name: K6-linked polyubiquitin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently and non-covalently with a polymer of ubiquitin formed by linkages between lysine residues at position 6 of the ubiquitin monomers." [GOC:sp, PMID:17525341, PMID:20351172]
is_a: GO:0031593 ! polyubiquitin binding
created_by: midori
creation_date: 2010-09-02T02:13:07Z

[Term]
id: GO:0071797
name: LUBAC complex
namespace: cellular_component
def: "A ubiquitin ligase complex that catalyzes linear head-to-tail polyubiquitin conjugation on its targets. In human the complex consists of RBCK1, RNF31 and SHARPIN, and has an MW of approximately 600 kDa, suggesting a heteromultimeric assembly of its subunits. LUBAC stands for Linear Ubiquitin Chain Assembly Complex." [GOC:sp, PMID:17006537, PMID:19136968, PMID:21455180]
is_a: GO:0000151 ! ubiquitin ligase complex
created_by: midori
creation_date: 2010-09-02T04:09:55Z

[Term]
id: GO:0071798
name: response to prostaglandin D
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin D stimulus." [GOC:sl]
synonym: "response to prostaglandin D stimulus" EXACT [GOC:dos]
is_a: GO:0034694 ! response to prostaglandin
created_by: midori
creation_date: 2010-09-03T10:48:03Z

[Term]
id: GO:0071799
name: cellular response to prostaglandin D stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin D stimulus." [GOC:sl]
is_a: GO:0071379 ! cellular response to prostaglandin stimulus
is_a: GO:0071798 ! response to prostaglandin D
created_by: midori
creation_date: 2010-09-03T10:48:35Z

[Term]
id: GO:0071800
name: podosome assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a podosome, an actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell." [GOC:mah, GOC:sl]
is_a: GO:0006461 ! protein complex assembly
is_a: GO:0070925 ! organelle assembly
created_by: midori
creation_date: 2010-09-03T11:00:45Z

[Term]
id: GO:0071801
name: regulation of podosome assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of podosome assembly." [GOC:mah, GOC:sl]
comment: Note that the assembly is regulated by several small GTPases of the Rab and Rho families.
is_a: GO:0043254 ! regulation of protein complex assembly
is_a: GO:1902115 ! regulation of organelle assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071800 ! podosome assembly
relationship: regulates GO:0071800 ! podosome assembly
created_by: midori
creation_date: 2010-09-03T01:34:29Z

[Term]
id: GO:0071802
name: negative regulation of podosome assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of podosome assembly." [GOC:mah, GOC:sl]
synonym: "down regulation of podosome assembly" EXACT [GOC:mah]
synonym: "down-regulation of podosome assembly" EXACT [GOC:mah]
synonym: "downregulation of podosome assembly" EXACT [GOC:mah]
synonym: "inhibition of podosome assembly" NARROW [GOC:mah]
is_a: GO:0031333 ! negative regulation of protein complex assembly
is_a: GO:0071801 ! regulation of podosome assembly
is_a: GO:1902116 ! negative regulation of organelle assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071800 ! podosome assembly
relationship: negatively_regulates GO:0071800 ! podosome assembly
created_by: midori
creation_date: 2010-09-03T01:49:14Z

[Term]
id: GO:0071803
name: positive regulation of podosome assembly
namespace: biological_process
def: "Any process that activates or increases the rate or extent of podosome assembly." [GOC:mah, GOC:sl]
synonym: "activation of podosome assembly" NARROW [GOC:mah]
synonym: "stimulation of podosome assembly" NARROW [GOC:mah]
synonym: "up regulation of podosome assembly" EXACT [GOC:mah]
synonym: "up-regulation of podosome assembly" EXACT [GOC:mah]
synonym: "upregulation of podosome assembly" EXACT [GOC:mah]
is_a: GO:0031334 ! positive regulation of protein complex assembly
is_a: GO:0071801 ! regulation of podosome assembly
is_a: GO:1902117 ! positive regulation of organelle assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071800 ! podosome assembly
relationship: positively_regulates GO:0071800 ! podosome assembly
created_by: midori
creation_date: 2010-09-03T01:50:50Z

[Term]
id: GO:0071804
name: cellular potassium ion transport
namespace: biological_process
def: "The directed movement of potassium (K) ions into, out of, or within a cell." [GOC:mah, GOC:vw]
is_a: GO:0006813 ! potassium ion transport
is_a: GO:0044763 ! single-organism cellular process
created_by: midori
creation_date: 2010-09-03T02:39:22Z

[Term]
id: GO:0071805
name: potassium ion transmembrane transport
namespace: biological_process
def: "A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "potassium ion membrane transport" EXACT []
is_a: GO:0071804 ! cellular potassium ion transport
is_a: GO:0098662 ! inorganic cation transmembrane transport
created_by: midori
creation_date: 2010-09-03T02:43:49Z

[Term]
id: GO:0071806
name: protein transmembrane transport
namespace: biological_process
def: "The directed movement of a protein across a membrane by means of some agent such as a transporter or pore." [GOC:mah, GOC:vw]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "protein membrane transport" EXACT []
is_a: GO:0015031 ! protein transport
is_a: GO:0055085 ! transmembrane transport
created_by: midori
creation_date: 2010-09-03T02:54:26Z

[Term]
id: GO:0071807
name: replication fork arrest involved in DNA replication termination
namespace: biological_process
def: "A replication fork arrest process that contributes to the termination of DNA replication." [GOC:mah, PMID:17347517, PMID:20797631]
is_a: GO:0043111 ! replication fork arrest
intersection_of: GO:0043111 ! replication fork arrest
intersection_of: part_of GO:0006274 ! DNA replication termination
relationship: part_of GO:0006274 ! DNA replication termination
created_by: midori
creation_date: 2010-09-03T03:26:38Z

[Term]
id: GO:0071808
name: satellite fibril
namespace: cellular_component
def: "An axoneme part that is found in the flagella of mammalian sperm and is located in the middle piece between the outer dense fibers (on the concave side of outer dense fibers as seen in cross-section)." [GOC:mah, GOC:sl, PMID:20108326]
is_a: GO:0044447 ! axoneme part
created_by: midori
creation_date: 2010-09-03T03:42:14Z

[Term]
id: GO:0071809
name: regulation of fever generation by regulation of prostaglandin biosynthesis
namespace: biological_process
def: "Any process that modulates the rate or extent of fever generation via regulation of the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin." [GOC:BHF, GOC:dph, GOC:mah]
is_a: GO:0031392 ! regulation of prostaglandin biosynthetic process
is_a: GO:0031620 ! regulation of fever generation
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: regulates GO:0100008 ! regulation of fever generation by prostaglandin biosynthetic process
relationship: regulates GO:0100008 ! regulation of fever generation by prostaglandin biosynthetic process
created_by: midori
creation_date: 2010-09-03T05:07:17Z

[Term]
id: GO:0071810
name: regulation of fever generation by regulation of prostaglandin secretion
namespace: biological_process
def: "Any process that modulates the rate or extent of fever generation via regulation of the frequency, rate or extent of the regulated release of a prostaglandin from a cell." [GOC:BHF, GOC:dph, GOC:mah]
is_a: GO:0031620 ! regulation of fever generation
is_a: GO:0032306 ! regulation of prostaglandin secretion
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: regulates GO:0100009 ! regulation of fever generation by prostaglandin secretion
relationship: regulates GO:0100009 ! regulation of fever generation by prostaglandin secretion
created_by: midori
creation_date: 2010-09-03T05:09:27Z

[Term]
id: GO:0071811
name: positive regulation of fever generation by positive regulation of prostaglandin biosynthesis
namespace: biological_process
def: "Any process that increases the rate or extent of fever generation via positive regulation of the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin." [GOC:BHF, GOC:dph, GOC:mah]
is_a: GO:0031394 ! positive regulation of prostaglandin biosynthetic process
is_a: GO:0031622 ! positive regulation of fever generation
is_a: GO:0071809 ! regulation of fever generation by regulation of prostaglandin biosynthesis
intersection_of: GO:0031394 ! positive regulation of prostaglandin biosynthetic process
intersection_of: positively_regulates GO:0001660 ! fever generation
relationship: positively_regulates GO:0001660 ! fever generation
created_by: midori
creation_date: 2010-09-03T05:10:05Z

[Term]
id: GO:0071812
name: positive regulation of fever generation by positive regulation of prostaglandin secretion
namespace: biological_process
def: "Any process that increases the rate or extent of fever generation via positive regulation of the frequency, rate or extent of the regulated release of a prostaglandin from a cell." [GOC:BHF, GOC:dph, GOC:mah]
is_a: GO:0031622 ! positive regulation of fever generation
is_a: GO:0032308 ! positive regulation of prostaglandin secretion
is_a: GO:0071810 ! regulation of fever generation by regulation of prostaglandin secretion
intersection_of: GO:0031622 ! positive regulation of fever generation
intersection_of: positively_regulates GO:0032310 ! prostaglandin secretion
relationship: positively_regulates GO:0032310 ! prostaglandin secretion
created_by: midori
creation_date: 2010-09-03T05:10:36Z

[Term]
id: GO:0071813
name: lipoprotein particle binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a lipoprotein particle. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids." [CHEBI:6495, GOC:BHF, GOC:mah]
synonym: "lipoprotein binding" RELATED [GOC:mah]
synonym: "plasma lipoprotein binding" RELATED [GOC:mah]
synonym: "plasma lipoprotein particle binding" EXACT [GOC:mah]
is_a: GO:0071814 ! protein-lipid complex binding
created_by: midori
creation_date: 2010-09-06T03:16:01Z

[Term]
id: GO:0071814
name: protein-lipid complex binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a protein-lipid complex, any macromolecular complex that contains both protein and lipid molecules." [GOC:BHF, GOC:mah]
is_a: GO:0044877 ! macromolecular complex binding
created_by: midori
creation_date: 2010-09-06T04:26:27Z

[Term]
id: GO:0071815
name: intermediate-density lipoprotein particle binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a intermediate-density lipoprotein particle, a triglyceride-rich lipoprotein particle that typically contains APOB100, APOE and APOCs and has a density of 1.006-1.019 g/ml and a diameter of between 25-30 nm." [GOC:BHF, GOC:mah]
synonym: "IDL binding" EXACT [GOC:BHF]
synonym: "intermediate-density lipoprotein binding" EXACT [GOC:dph]
is_a: GO:0071813 ! lipoprotein particle binding
created_by: midori
creation_date: 2010-09-06T04:28:35Z

[Term]
id: GO:0071816
name: tail-anchored membrane protein insertion into ER membrane
namespace: biological_process
def: "A process of protein insertion into the endoplasmic reticulum (ER) membrane in which a tail-anchored (TA) transmembrane protein is incorporated into an endoplasmic reticulum (ER) membrane. TA transmembrane protein, also named type II transmembrane proteins, contain a single C- terminal transmembrane region." [GOC:mah, GOC:sp, PMID:20516149, PMID:20676083]
synonym: "protein insertion of tail-anchored membrane proteins into ER membrane" EXACT [GOC:sp]
synonym: "tail-anchored membrane protein insertion into endoplasmic reticulum membrane" EXACT [GOC:mah]
synonym: "type II transmembrane protein insertion into ER membrane" EXACT [GOC:mah, GOC:sp]
is_a: GO:0045048 ! protein insertion into ER membrane
created_by: midori
creation_date: 2010-09-06T04:55:16Z

[Term]
id: GO:0071817
name: MMXD complex
namespace: cellular_component
def: "A protein complex that contains the proteins MMS19, MIP18 and XPD, localizes to mitotic spindle during mitosis, and is required for proper chromosome segregation." [GOC:sp, PMID:20797633]
synonym: "MMS19-MIP18-XPD complex" EXACT [GOC:sp, PMID:20797633]
is_a: GO:0043234 ! protein complex
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0005819 ! spindle
created_by: midori
creation_date: 2010-09-07T10:53:42Z

[Term]
id: GO:0071818
name: BAT3 complex
namespace: cellular_component
def: "A protein complex consisting of BAT3 (BAG6) and its cofactors. In mammals these cofactors are TRC35 (GET4) and UBL4A. It facilitates tail-anchored protein capture by ASNA1/TRC4 and also chaperones polypeptides from the endoplasmic reticulum retrotranslocation machinery to the proteasome, maintaining the solubility of substrates to improve ER-associated protein degradation (ERAD)." [GOC:bf, GOC:mah, GOC:sp, PMID:20676083, PMID:21636303]
synonym: "Bag6 complex" EXACT [PMID:21636303]
synonym: "BAG6-UBL4A-TRC35 complex" EXACT [PMID:21636303]
synonym: "BAT3-TRC35-UBL4A complex" RELATED [PMID:20676083]
is_a: GO:0000502 ! proteasome complex
is_a: GO:0072379 ! ER membrane insertion complex
created_by: midori
creation_date: 2010-09-07T11:01:38Z

[Term]
id: GO:0071819
name: DUBm complex
namespace: cellular_component
def: "A protein complex that forms part of SAGA-type complexes SAGA and SLIK, and mediates deubiquitination of histone H2B. In S. cerevisiae, the DUBm consists of the proteins Ubp8p, Sgf11p, Sus1p, and Sgf73p." [PMID:19226466, PMID:20395473]
synonym: "deubiquitinating module" EXACT [GOC:jp, PMID:20395473]
synonym: "deubiquitination module" EXACT [PMID:19226466]
synonym: "SAGA DUBm complex" NARROW [GOC:jp]
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part
created_by: midori
creation_date: 2010-09-07T11:19:28Z

[Term]
id: GO:0071820
name: N-box binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an N-box, a DNA motif with the consensus sequence CACNAG that is found in the promoters of genes expressed preferentially at synapses." [GOC:yaf, PMID:11498047]
comment: Note that as agreed during the transcription overhaul, terms specifying binding to specific transcription regulatory motifs are no longer being created. The level of specificity GO has decided to go to is the "core promoter", "core promoter proximal region" and "enhancer". To capture more detail, please consider using column 16.
synonym: "N box binding" EXACT [GOC:mah]
synonym: "N-box promoter binding" EXACT [GOC:mah]
is_a: GO:0044212 ! transcription regulatory region DNA binding
created_by: midori
creation_date: 2010-09-07T11:55:32Z

[Term]
id: GO:0071821
name: FANCM-MHF complex
namespace: cellular_component
def: "A protein complex contains the proteins FANCM and MHF, or their orthologs, plays an essential role in DNA remodeling, protects replication forks, and is conserved in eukaryotes." [GOC:mah, GOC:vw, PMID:20347428]
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part
created_by: midori
creation_date: 2010-09-07T12:08:38Z

[Term]
id: GO:0071822
name: protein complex subunit organization
namespace: biological_process
def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex." [GOC:mah]
synonym: "protein complex subunit organisation" EXACT [GOC:mah]
is_a: GO:0043933 ! macromolecular complex subunit organization
created_by: midori
creation_date: 2010-09-08T10:01:42Z

[Term]
id: GO:0071823
name: protein-carbohydrate complex subunit organization
namespace: biological_process
def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-carbohydrate complex." [GOC:mah]
synonym: "protein-carbohydrate complex subunit organisation" EXACT [GOC:mah]
is_a: GO:0043933 ! macromolecular complex subunit organization
created_by: midori
creation_date: 2010-09-08T10:03:03Z

[Term]
id: GO:0071824
name: protein-DNA complex subunit organization
namespace: biological_process
def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA complex." [GOC:mah]
synonym: "DNA-protein complex subunit organization" EXACT [GOC:mah]
synonym: "protein-DNA complex subunit organisation" EXACT [GOC:mah]
is_a: GO:0043933 ! macromolecular complex subunit organization
created_by: midori
creation_date: 2010-09-08T10:03:26Z

[Term]
id: GO:0071825
name: protein-lipid complex subunit organization
namespace: biological_process
def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-lipid complex." [GOC:mah]
synonym: "protein-lipid complex subunit organisation" EXACT [GOC:mah]
is_a: GO:0043933 ! macromolecular complex subunit organization
created_by: midori
creation_date: 2010-09-08T10:04:36Z

[Term]
id: GO:0071826
name: ribonucleoprotein complex subunit organization
namespace: biological_process
def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a ribonucleoprotein complex." [GOC:mah]
synonym: "protein-RNA complex subunit organization" EXACT [GOC:mah]
synonym: "ribonucleoprotein complex subunit organisation" EXACT [GOC:mah]
synonym: "RNA-protein complex subunit organization" EXACT [GOC:mah]
is_a: GO:0043933 ! macromolecular complex subunit organization
created_by: midori
creation_date: 2010-09-08T10:10:35Z

[Term]
id: GO:0071827
name: plasma lipoprotein particle organization
namespace: biological_process
def: "A protein-lipid complex subunit organization process that results in the formation, disassembly, or alteration of a plasma lipoprotein particle. A plasma lipoprotein particle is a spherical particle with a hydrophobic core of triglycerides and/or cholesterol esters, surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins." [GOC:BHF, GOC:mah]
synonym: "plasma lipoprotein particle organisation" EXACT [GOC:mah]
is_a: GO:0044707 ! single-multicellular organism process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0071825 ! protein-lipid complex subunit organization
created_by: midori
creation_date: 2010-09-08T10:32:26Z

[Term]
id: GO:0071828
name: apolipoprotein E recycling
namespace: biological_process
def: "The process in which chylomicron remnant-associated apolipoprotein E is internalized by endocytosis, localized to recycling endosomes and then secreted in association with a high-density lipoprotein particle." [GOC:BHF, PMID:16373604]
synonym: "APOE recycling" EXACT [GOC:BHF]
is_a: GO:0015031 ! protein transport
relationship: part_of GO:0034380 ! high-density lipoprotein particle assembly
relationship: part_of GO:0034382 ! chylomicron remnant clearance
created_by: midori
creation_date: 2010-09-08T11:05:15Z

[Term]
id: GO:0071829
name: plasma lipoprotein particle disassembly
namespace: biological_process
def: "The disaggregation of a plasma lipoprotein particle into its constituent components." [GOC:mah]
is_a: GO:0032987 ! protein-lipid complex disassembly
is_a: GO:0071827 ! plasma lipoprotein particle organization
relationship: part_of GO:0097006 ! regulation of plasma lipoprotein particle levels
created_by: midori
creation_date: 2010-09-08T11:14:21Z

[Term]
id: GO:0071830
name: triglyceride-rich lipoprotein particle clearance
namespace: biological_process
def: "The process in which a triglyceride-rich lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF]
is_a: GO:0034381 ! plasma lipoprotein particle clearance
created_by: midori
creation_date: 2010-09-08T11:23:55Z

[Term]
id: GO:0071831
name: intermediate-density lipoprotein particle clearance
namespace: biological_process
def: "The process in which a intermediate-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF]
synonym: "IDL clearance" EXACT [GOC:BHF]
is_a: GO:0071830 ! triglyceride-rich lipoprotein particle clearance
created_by: midori
creation_date: 2010-09-08T11:26:12Z

[Term]
id: GO:0071832
name: peptide pheromone export involved in conjugation
namespace: biological_process
def: "The directed movement of a peptide pheromone out of a cell by a secretion or export pathway used solely for the export of peptide pheromones that contributes to the union or introduction of genetic information from compatible mating types that results in a genetically different individual. Conjugation requires direct cellular contact between the organisms." [GOC:elh, GOC:jh, GOC:mah]
is_a: GO:0000770 ! peptide pheromone export
intersection_of: GO:0000770 ! peptide pheromone export
intersection_of: part_of GO:0000746 ! conjugation
relationship: part_of GO:0000746 ! conjugation
created_by: midori
creation_date: 2010-09-09T11:06:46Z

[Term]
id: GO:0071833
name: peptide pheromone export involved in conjugation with cellular fusion
namespace: biological_process
def: "The directed movement of a peptide pheromone out of a cell by a secretion or export pathway used solely for the export of peptide pheromones that contributes to a conjugation process that results in the union of cellular and genetic information from compatible mating types." [GOC:elh, GOC:jh, GOC:mah]
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0071832 ! peptide pheromone export involved in conjugation
intersection_of: GO:0000770 ! peptide pheromone export
intersection_of: part_of GO:0000747 ! conjugation with cellular fusion
relationship: part_of GO:0000747 ! conjugation with cellular fusion
created_by: midori
creation_date: 2010-09-09T11:09:43Z

[Term]
id: GO:0071834
name: mating pheromone secretion
namespace: biological_process
def: "The regulated release of a mating pheromone, a peptide hormone that induces a behavioral or physiological response(s) from a responding organism or cell, that contributes to a process of sexual reproduction." [GOC:mah]
synonym: "mating-type pheromone secretion" EXACT [GOC:vw]
is_a: GO:0030072 ! peptide hormone secretion
created_by: midori
creation_date: 2010-09-09T11:22:35Z

[Term]
id: GO:0071835
name: mating pheromone secretion involved in conjugation
namespace: biological_process
def: "The regulated release of a mating pheromone, a peptide hormone that induces a behavioral or physiological response(s) from a responding organism or cell, that contributes to the union or introduction of genetic information from compatible mating types that results in a genetically different individual. Conjugation requires direct cellular contact between the organisms." [GOC:elh, GOC:jh, GOC:mah]
synonym: "mating-type pheromone secretion involved in conjugation" EXACT [GOC:mah, GOC:vw]
is_a: GO:0071834 ! mating pheromone secretion
intersection_of: GO:0071834 ! mating pheromone secretion
intersection_of: part_of GO:0000746 ! conjugation
relationship: part_of GO:0000746 ! conjugation
created_by: midori
creation_date: 2010-09-09T11:23:19Z

[Term]
id: GO:0071836
name: nectar secretion
namespace: biological_process
def: "The controlled release of a nectar by a cell or a tissue. Nectar is a fluid secreted by many angiosperms to promote pollination by providing a reward to pollinators. Nectar may also deter certain organisms from visiting or play other biological roles. Nectar is a complex solution that may include the following types of compounds: sugars, amino acids, organic acids, alkaloids, flavonoids, glycosides, vitamins, phenolics, metal ions, oils, free fatty acids, and proteins." [GOC:kad, PMID:19861655]
synonym: "nectar production" RELATED [GOC:kad]
is_a: GO:0046903 ! secretion
created_by: midori
creation_date: 2010-09-09T01:06:04Z

[Term]
id: GO:0071837
name: HMG box domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an HMG box domain, a protein domain that consists of three helices in an irregular array. HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin." [GOC:yaf, InterPro:IPR009071, PMID:18445004]
is_a: GO:0019904 ! protein domain specific binding
created_by: midori
creation_date: 2010-09-10T12:05:45Z

[Term]
id: GO:0071838
name: cell proliferation in bone marrow
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population in the bone marrow." [GOC:mah, GOC:yaf, PMID:17063141]
synonym: "bone marrow cell proliferation" EXACT [GOC:yaf]
is_a: GO:0008283 ! cell proliferation
created_by: midori
creation_date: 2010-09-10T12:15:41Z

[Term]
id: GO:0071839
name: apoptotic process in bone marrow
namespace: biological_process
def: "The apoptotic process in cells in the bone marrow." [GOC:mah, GOC:mtg_apoptosis, PMID:17063141]
synonym: "apoptosis in bone marrow" NARROW []
synonym: "bone marrow cell apoptosis" EXACT [GOC:yaf]
synonym: "bone marrow cell programmed cell death by apoptosis" EXACT [GOC:mah]
synonym: "killing of bone marrow cells" EXACT [GOC:mah]
synonym: "programmed cell death of bone marrow cells by apoptosis" EXACT [GOC:mah]
synonym: "programmed cell death, bone marrow cells" EXACT [GOC:mah]
is_a: GO:0006915 ! apoptotic process
created_by: midori
creation_date: 2010-09-10T12:19:18Z

[Term]
id: GO:0071840
name: cellular component organization or biogenesis
namespace: biological_process
alt_id: GO:0071841
def: "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:mah]
synonym: "cellular component organisation or biogenesis" EXACT [GOC:mah]
synonym: "cellular component organisation or biogenesis at cellular level" EXACT [GOC:mah]
synonym: "cellular component organization or biogenesis at cellular level" EXACT []
is_a: GO:0008150 ! biological_process
created_by: midori
creation_date: 2010-09-10T01:39:16Z

[Term]
id: GO:0071846
name: actin filament debranching
namespace: biological_process
def: "An actin filament severing process that results in the removal of actin filament branches specifically at the branch points." [GOC:jh, GOC:mah, PMID:20362448]
is_a: GO:0051014 ! actin filament severing
created_by: midori
creation_date: 2010-09-10T02:15:42Z

[Term]
id: GO:0071847
name: TNFSF11-mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of tumor necrosis factor ligand superfamily member 11 (TNFSF11) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:signaling, PMID:18606301, PR:000002107]
synonym: "RANKL-mediated signaling pathway" EXACT [GOC:BHF]
synonym: "receptor activator of nuclear factor kappa-B ligand signaling pathway" EXACT [Wikipedia:RANKL]
synonym: "TNF-related activation-induced cytokine-mediated signaling pathway" EXACT [Wikipedia:RANKL]
synonym: "TNFSF11-mediated signalling pathway" EXACT [GOC:mah]
synonym: "tumor necrosis factor superfamily member 11-mediated signaling pathway" EXACT [Wikipedia:RANKL]
is_a: GO:0033209 ! tumor necrosis factor-mediated signaling pathway
created_by: midori
creation_date: 2010-09-10T02:22:42Z

[Term]
id: GO:0071848
name: positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling
namespace: biological_process
def: "Any TNFSF11-mediated signaling process that increases the rate, frequency, or extent of the ERK1 and ERK2 cascade." [GOC:BHF, PMID:18606301]
synonym: "positive regulation of ERK1 and ERK2 cascade via RANKL-mediated signaling" EXACT [GOC:BHF]
synonym: "positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signalling" EXACT [GOC:mah]
is_a: GO:0070374 ! positive regulation of ERK1 and ERK2 cascade
is_a: GO:0071847 ! TNFSF11-mediated signaling pathway
created_by: midori
creation_date: 2010-09-10T02:25:31Z

[Term]
id: GO:0071849
name: G1 cell cycle arrest in response to nitrogen starvation
namespace: biological_process
def: "The process in which the cell cycle is halted during G1 phase, as a result of deprivation of nitrogen." [GOC:vw]
is_a: GO:0007050 ! cell cycle arrest
created_by: midori
creation_date: 2010-09-10T02:46:11Z

[Term]
id: GO:0071850
name: mitotic cell cycle arrest
namespace: biological_process
def: "The process in which the mitotic cell cycle is halted during one of the normal phases (G1, S, G2, M)." [GOC:mah]
synonym: "arrest of mitotic cell cycle progression" EXACT [GOC:mah]
synonym: "cessation of mitotic cell cycle" EXACT [GOC:mah]
synonym: "termination of mitotic cell cycle" EXACT [GOC:mah]
is_a: GO:0007050 ! cell cycle arrest
created_by: midori
creation_date: 2010-09-10T02:56:30Z

[Term]
id: GO:0071851
name: mitotic G1 cell cycle arrest in response to nitrogen starvation
namespace: biological_process
def: "The process in which the mitotic cell cycle is halted during G1 phase, as a result of deprivation of nitrogen." [GOC:vw]
synonym: "G1 mitotic cell cycle arrest in response to nitrogen starvation" EXACT [GOC:vw]
is_a: GO:0071849 ! G1 cell cycle arrest in response to nitrogen starvation
is_a: GO:0071850 ! mitotic cell cycle arrest
created_by: midori
creation_date: 2010-09-10T02:58:09Z

[Term]
id: GO:0071852
name: fungal-type cell wall organization or biogenesis
namespace: biological_process
def: "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a fungal-type cell wall." [GOC:mah]
synonym: "fungal-type cell wall organisation or biogenesis" EXACT [GOC:mah]
synonym: "fungal-type cell wall organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0071554 ! cell wall organization or biogenesis
created_by: midori
creation_date: 2010-09-10T03:07:55Z

[Term]
id: GO:0071853
name: fungal-type cell wall disassembly
namespace: biological_process
def: "A cellular process that results in the breakdown of a fungal-type cell wall." [GOC:mah]
is_a: GO:0031505 ! fungal-type cell wall organization
is_a: GO:0044277 ! cell wall disassembly
created_by: midori
creation_date: 2010-09-10T03:10:47Z

[Term]
id: GO:0071854
name: cell wall macromolecule catabolic process involved in fungal-type cell wall disassembly
namespace: biological_process
def: "The chemical reactions and pathways that result in the breakdown of macromolecules that form part of a cell wall, and contributes to the breakdown of the fungal-type cell wall." [GOC:mah]
is_a: GO:0070910 ! cell wall macromolecule catabolic process involved in cell wall disassembly
intersection_of: GO:0016998 ! cell wall macromolecule catabolic process
intersection_of: part_of GO:0071853 ! fungal-type cell wall disassembly
relationship: part_of GO:0071853 ! fungal-type cell wall disassembly
created_by: midori
creation_date: 2010-09-10T03:12:08Z

[Term]
id: GO:0071855
name: neuropeptide receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a neuropeptide receptor." [GOC:kmv, GOC:mah]
is_a: GO:0001664 ! G-protein coupled receptor binding
created_by: midori
creation_date: 2010-09-10T03:21:43Z

[Term]
id: GO:0071857
name: beta-endorphin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a beta-endorphin receptor." [GOC:kmv, GOC:mah]
is_a: GO:0071855 ! neuropeptide receptor binding
created_by: midori
creation_date: 2010-09-10T03:23:01Z

[Term]
id: GO:0071858
name: corazonin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a corazonin receptor." [GOC:kmv, GOC:mah]
is_a: GO:0071855 ! neuropeptide receptor binding
created_by: midori
creation_date: 2010-09-10T03:23:40Z

[Term]
id: GO:0071859
name: neuropeptide F receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a neuropeptide F receptor." [GOC:kmv, GOC:mah]
is_a: GO:0071855 ! neuropeptide receptor binding
created_by: midori
creation_date: 2010-09-10T03:23:56Z

[Term]
id: GO:0071860
name: proctolin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a proctolin receptor." [GOC:kmv, GOC:mah]
is_a: GO:0071855 ! neuropeptide receptor binding
created_by: midori
creation_date: 2010-09-10T03:24:19Z

[Term]
id: GO:0071861
name: tachykinin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a tachykinin receptor." [GOC:kmv, GOC:mah]
is_a: GO:0071855 ! neuropeptide receptor binding
created_by: midori
creation_date: 2010-09-10T03:24:34Z

[Term]
id: GO:0071862
name: protein phosphatase type 1 activator activity
namespace: molecular_function
def: "Increases the activity of the enzyme protein phosphatase type 1." [GOC:vw]
is_a: GO:0008599 ! protein phosphatase type 1 regulator activity
is_a: GO:0072542 ! protein phosphatase activator activity
created_by: midori
creation_date: 2010-09-10T03:39:56Z

[Term]
id: GO:0071863
name: regulation of cell proliferation in bone marrow
namespace: biological_process
def: "A process that modulates the frequency, rate or extent of cell proliferation in the bone marrow." [GOC:mah, GOC:yaf, PMID:17063141]
synonym: "regulation of bone marrow cell proliferation" EXACT [GOC:yaf]
is_a: GO:0042127 ! regulation of cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071838 ! cell proliferation in bone marrow
relationship: regulates GO:0071838 ! cell proliferation in bone marrow
created_by: midori
creation_date: 2010-09-13T02:11:08Z

[Term]
id: GO:0071864
name: positive regulation of cell proliferation in bone marrow
namespace: biological_process
def: "A process that activates or increases the frequency, rate or extent of cell proliferation in the bone marrow." [GOC:mah, GOC:yaf, PMID:17063141]
synonym: "activation of cell proliferation in bone marrow" NARROW [GOC:mah]
synonym: "positive regulation of bone marrow cell proliferation" EXACT [GOC:yaf]
synonym: "stimulation of cell proliferation in bone marrow" NARROW [GOC:mah]
synonym: "up regulation of cell proliferation in bone marrow" EXACT [GOC:mah]
synonym: "up-regulation of cell proliferation in bone marrow" EXACT [GOC:mah]
synonym: "upregulation of cell proliferation in bone marrow" EXACT [GOC:mah]
is_a: GO:0008284 ! positive regulation of cell proliferation
is_a: GO:0071863 ! regulation of cell proliferation in bone marrow
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071838 ! cell proliferation in bone marrow
relationship: positively_regulates GO:0071838 ! cell proliferation in bone marrow
created_by: midori
creation_date: 2010-09-13T02:12:36Z

[Term]
id: GO:0071865
name: regulation of apoptotic process in bone marrow
namespace: biological_process
def: "Any process that modulates the occurrence or rate of cell death by apoptotic process in the bone marrow." [GOC:mah, GOC:mtg_apoptosis, GOC:yaf, PMID:17063141]
synonym: "regulation of apoptosis in bone marrow" NARROW []
is_a: GO:0042981 ! regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071839 ! apoptotic process in bone marrow
relationship: regulates GO:0071839 ! apoptotic process in bone marrow
created_by: midori
creation_date: 2010-09-13T02:16:43Z

[Term]
id: GO:0071866
name: negative regulation of apoptotic process in bone marrow
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the occurrence or rate of cell death by apoptotic process in the bone marrow." [GOC:mah, GOC:mtg_apoptosis, GOC:yaf, PMID:17063141]
synonym: "down regulation of apoptosis in bone marrow" EXACT [GOC:mah]
synonym: "down-regulation of apoptosis in bone marrow" EXACT [GOC:mah]
synonym: "downregulation of apoptosis in bone marrow" EXACT [GOC:mah]
synonym: "inhibition of apoptosis in bone marrow" NARROW [GOC:mah]
synonym: "negative regulation of apoptosis in bone marrow" NARROW []
synonym: "negative regulation of bone marrow cell apoptosis" EXACT [GOC:mah, GOC:yaf]
synonym: "negative regulation of bone marrow cell programmed cell death by apoptosis" EXACT [GOC:mah]
synonym: "negative regulation of killing of bone marrow cells" EXACT [GOC:mah]
synonym: "negative regulation of programmed cell death of bone marrow cells by apoptosis" EXACT [GOC:mah]
synonym: "negative regulation of programmed cell death, bone marrow cells" EXACT [GOC:mah]
is_a: GO:0043066 ! negative regulation of apoptotic process
is_a: GO:0071865 ! regulation of apoptotic process in bone marrow
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071839 ! apoptotic process in bone marrow
relationship: negatively_regulates GO:0071839 ! apoptotic process in bone marrow
created_by: midori
creation_date: 2010-09-13T02:17:38Z

[Term]
id: GO:0071867
name: response to monoamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monoamine stimulus. A monoamine is any of a group of molecular messengers that contain one amino group that is connected to an aromatic ring by ethylene group (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan." [CHEBI:35375, GOC:mah]
synonym: "response to monoamine stimulus" EXACT [GOC:dos]
is_a: GO:0010243 ! response to organonitrogen compound
created_by: midori
creation_date: 2010-09-13T02:36:37Z

[Term]
id: GO:0071868
name: cellular response to monoamine stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monoamine stimulus. A monoamine is any of a group of molecular messengers that contain one amino group that is connected to an aromatic ring by ethylene group (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan." [CHEBI:35375, GOC:mah]
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:0071867 ! response to monoamine
created_by: midori
creation_date: 2010-09-13T02:38:52Z

[Term]
id: GO:0071869
name: response to catecholamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catecholamine stimulus. A catecholamine is any of a group of biogenic amines that includes 4-(2-aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution." [CHEBI:33567, GOC:BHF, GOC:mah]
synonym: "response to catecholamine stimulus" EXACT [GOC:dos]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0071867 ! response to monoamine
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: midori
creation_date: 2010-09-13T02:51:13Z

[Term]
id: GO:0071870
name: cellular response to catecholamine stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catecholamine stimulus. A catecholamine is any of a group of biogenic amines that includes 4-(2-aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution." [CHEBI:33567, GOC:BHF, GOC:mah]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071868 ! cellular response to monoamine stimulus
is_a: GO:0071869 ! response to catecholamine
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: midori
creation_date: 2010-09-13T02:54:50Z

[Term]
id: GO:0071871
name: response to epinephrine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system." [CHEBI:33568, GOC:BHF, GOC:mah]
comment: Note that epinephrine and norepinephrine are ligands for the same receptors, and there are multiple adrenergic receptors.
synonym: "response to adrenaline stimulus" EXACT [GOC:mah]
synonym: "response to epinephrine stimulus" EXACT [GOC:dos]
is_a: GO:0071869 ! response to catecholamine
created_by: midori
creation_date: 2010-09-13T03:27:48Z

[Term]
id: GO:0071872
name: cellular response to epinephrine stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system." [CHEBI:33568, GOC:BHF, GOC:mah]
comment: Note that epinephrine and norepinephrine are ligands for the same receptors, and there are multiple adrenergic receptors.
synonym: "cellular response to adrenaline stimulus" EXACT [GOC:mah]
is_a: GO:0071870 ! cellular response to catecholamine stimulus
is_a: GO:0071871 ! response to epinephrine
created_by: midori
creation_date: 2010-09-13T03:31:40Z

[Term]
id: GO:0071873
name: response to norepinephrine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a norepinephrine stimulus. Norepinephrine is a catecholamine that has the formula C8H11NO3; it acts as a hormone, and as a neurotransmitter in most of the sympathetic nervous system." [CHEBI:33569, GOC:BHF, GOC:mah]
comment: Note that epinephrine and norepinephrine are ligands for the same receptors, and there are multiple adrenergic receptors.
synonym: "response to noradrenaline stimulus" EXACT [GOC:mah]
synonym: "response to norepinephrine stimulus" EXACT [GOC:dos]
is_a: GO:0071869 ! response to catecholamine
created_by: midori
creation_date: 2010-09-13T03:31:53Z

[Term]
id: GO:0071874
name: cellular response to norepinephrine stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a norepinephrine stimulus. Norepinephrine is a catecholamine that has the formula C8H11NO3; it acts as a hormone, and as a neurotransmitter in most of the sympathetic nervous system." [CHEBI:33569, GOC:BHF, GOC:mah]
comment: Note that epinephrine and norepinephrine are ligands for the same receptors, and there are multiple adrenergic receptors.
synonym: "cellular response to noradrenaline stimulus" EXACT [GOC:mah]
is_a: GO:0071870 ! cellular response to catecholamine stimulus
is_a: GO:0071873 ! response to norepinephrine
created_by: midori
creation_date: 2010-09-13T03:33:32Z

[Term]
id: GO:0071875
name: adrenergic receptor signaling pathway
namespace: biological_process
def: "A series of molecular signals generated as a consequence of an adrenergic receptor binding to one of its physiological ligands." [GOC:BHF]
synonym: "adrenergic receptor signalling pathway" EXACT [GOC:mah]
synonym: "adrenoceptor signaling pathway" EXACT [GOC:mah]
is_a: GO:0007186 ! G-protein coupled receptor signaling pathway
created_by: midori
creation_date: 2010-09-13T03:44:44Z

[Term]
id: GO:0071876
name: obsolete initiation of adrenergic receptor signal transduction
namespace: biological_process
def: "OBSOLETE. A process of signal initiation in which epinephrine or norepinephrine causes activation of an adrenergic receptor." [GOC:BHF, GOC:mah]
comment: This term was made obsolete because the meaning of the term is ambiguous.
synonym: "initiation of adrenergic receptor signal transduction" EXACT []
is_obsolete: true
consider: GO:0004935
consider: GO:0005179
consider: GO:0071872
consider: GO:0071874
consider: GO:0071875
created_by: midori
creation_date: 2010-09-13T04:05:38Z

[Term]
id: GO:0071877
name: regulation of adrenergic receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of an adrenergic receptor signaling pathway activity. An adrenergic receptor signaling pathway is the series of molecular signals generated as a consequence of an adrenergic receptor binding to one of its physiological ligands." [GOC:BHF, GOC:mah]
synonym: "regulation of adrenergic receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071875 ! adrenergic receptor signaling pathway
relationship: regulates GO:0071875 ! adrenergic receptor signaling pathway
created_by: midori
creation_date: 2010-09-13T04:12:10Z

[Term]
id: GO:0071878
name: negative regulation of adrenergic receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of adrenergic receptor protein signaling pathway activity. An adrenergic receptor signaling pathway is the series of molecular signals generated as a consequence of an adrenergic receptor binding to one of its physiological ligands." [GOC:BHF, GOC:mah]
synonym: "negative regulation of adrenergic receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0045744 ! negative regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:0071877 ! regulation of adrenergic receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071875 ! adrenergic receptor signaling pathway
relationship: negatively_regulates GO:0071875 ! adrenergic receptor signaling pathway
created_by: midori
creation_date: 2010-09-13T04:15:34Z

[Term]
id: GO:0071879
name: positive regulation of adrenergic receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the adrenergic receptor protein signaling pathway. An adrenergic receptor signaling pathway is the series of molecular signals generated as a consequence of an adrenergic receptor binding to one of its physiological ligands." [GOC:BHF, GOC:mah]
synonym: "positive regulation of adrenergic receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0045745 ! positive regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:0071877 ! regulation of adrenergic receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071875 ! adrenergic receptor signaling pathway
relationship: positively_regulates GO:0071875 ! adrenergic receptor signaling pathway
created_by: midori
creation_date: 2010-09-13T04:15:57Z

[Term]
id: GO:0071880
name: adenylate cyclase-activating adrenergic receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of an adrenergic receptor binding to its physiological ligand, where the pathway proceeds with activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP (cAMP)." [GOC:BHF, GOC:mah, GOC:signaling]
synonym: "activation of adenylate cyclase activity by adrenergic receptor signaling pathway" RELATED [GOC:signaling]
synonym: "activation of adenylate cyclase activity by adrenergic receptor signalling pathway" EXACT [GOC:mah]
synonym: "adrenergic receptor, adenylate cyclase activating pathway" EXACT [GOC:mah]
synonym: "adrenergic receptor, adenylyl cyclase activating pathway" EXACT [GOC:mah]
is_a: GO:0007189 ! adenylate cyclase-activating G-protein coupled receptor signaling pathway
is_a: GO:0071875 ! adrenergic receptor signaling pathway
created_by: midori
creation_date: 2010-09-13T04:21:28Z

[Term]
id: GO:0071881
name: adenylate cyclase-inhibiting adrenergic receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of an adrenergic receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP)." [GOC:BHF, GOC:mah, GOC:signaling]
synonym: "adrenergic receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:mah]
synonym: "adrenergic receptor, adenylyl cyclase inhibiting pathway" EXACT [GOC:mah]
synonym: "inhibition of adenylate cyclase activity by adrenergic receptor signaling pathway" RELATED [GOC:signaling]
synonym: "inhibition of adenylate cyclase activity by adrenergic receptor signalling pathway" RELATED [GOC:mah]
is_a: GO:0007193 ! adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
is_a: GO:0071875 ! adrenergic receptor signaling pathway
created_by: midori
creation_date: 2010-09-13T04:22:53Z

[Term]
id: GO:0071882
name: phospholipase C-activating adrenergic receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of an adrenergic receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:BHF, GOC:mah, GOC:signaling]
synonym: "activation of phospholipase C activity by adrenergic receptor signaling pathway" RELATED [GOC:bf]
synonym: "activation of phospholipase C activity by adrenergic receptor signalling pathway" RELATED [GOC:mah]
synonym: "adrenergic receptor, phospholipase C activating pathway" RELATED [GOC:mah]
is_a: GO:0007200 ! phospholipase C-activating G-protein coupled receptor signaling pathway
is_a: GO:0071875 ! adrenergic receptor signaling pathway
created_by: midori
creation_date: 2010-09-13T04:32:03Z

[Term]
id: GO:0071883
name: activation of MAPK activity by adrenergic receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of an adrenergic receptor binding to its physiological ligand, followed by the activation of a MAP kinase." [GOC:BHF, GOC:mah]
synonym: "activation of MAP kinase activity by adrenergic receptor signaling pathway" EXACT [GOC:mah]
synonym: "activation of MAP kinase activity by adrenergic receptor signalling pathway" EXACT [GOC:mah]
synonym: "activation of MAPK activity by adrenergic receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0000187 ! activation of MAPK activity
is_a: GO:0071875 ! adrenergic receptor signaling pathway
created_by: midori
creation_date: 2010-09-13T04:34:47Z

[Term]
id: GO:0071884
name: vitamin D receptor activator activity
namespace: molecular_function
def: "Interacting (directly or indirectly) with vitamin D receptors such that the proportion of receptors in the active form is increased." [GOC:BHF, GOC:vk]
is_a: GO:0030546 ! receptor activator activity
created_by: midori
creation_date: 2010-09-13T04:51:59Z

[Term]
id: GO:0071885
name: N-terminal protein N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to the alpha-amino group of the N-terminal amino or imino acid residue of a protein substrate. For example, yeast Tae1p and mammalian family member METTL11A preferentially modify the N-terminal residue of substrates with the N-terminal sequence X-Pro-Lys, where X can be Pro, Ala, or Ser." [PMID:20481588]
synonym: "X-Pro-Lys N-terminal methyltransferase" NARROW [GOC:rn]
is_a: GO:0008276 ! protein methyltransferase activity
created_by: midori
creation_date: 2010-09-13T04:53:57Z

[Term]
id: GO:0071886
name: 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the amine 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine, a serotonin receptor agonist that can act as a psychedelic drug." [CHEBI:100436, GOC:yaf, PMID:19057895]
synonym: "(+/-)2-(4-iodo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine binding" EXACT [CHEBI:100436]
synonym: "1-(4-iodo-2,5-dimethoxyphenyl)-2-aminopropane binding" EXACT [PMID:19057895]
synonym: "4-iodo-2,5-dimethoxyphenylisopropylamine binding" EXACT [PubChem_Compound:1229]
is_a: GO:0043176 ! amine binding
is_a: GO:0097159 ! organic cyclic compound binding
created_by: midori
creation_date: 2010-09-14T12:29:36Z

[Term]
id: GO:0071887
name: leukocyte apoptotic process
namespace: biological_process
def: "Any apoptotic process in a leukocyte, an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." [CL:0000738, GOC:BHF, GOC:mah, GOC:mtg_apoptosis]
comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542).
synonym: "leukocyte apoptosis" NARROW []
is_a: GO:0006915 ! apoptotic process
created_by: midori
creation_date: 2010-09-14T12:44:09Z

[Term]
id: GO:0071888
name: macrophage apoptotic process
namespace: biological_process
def: "Any apoptotic process in a macrophage, a mononuclear phagocyte present in a variety of tissues." [CL:0000235, GOC:BHF, GOC:mah, GOC:mtg_apoptosis]
comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542).
synonym: "activation-induced cell death" RELATED [GOC:yaf]
synonym: "AICD" RELATED [GOC:yaf]
synonym: "macrophage apoptosis" NARROW []
is_a: GO:0006925 ! inflammatory cell apoptotic process
is_a: GO:0033028 ! myeloid cell apoptotic process
is_a: GO:0071887 ! leukocyte apoptotic process
created_by: midori
creation_date: 2010-09-14T12:50:40Z

[Term]
id: GO:0071889
name: 14-3-3 protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxyl terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins." [GOC:cna, GOC:mah, InterPro:IPR000308, PMID:15167810, PMID:19575580, PR:000003237]
is_a: GO:0005515 ! protein binding
created_by: midori
creation_date: 2010-09-14T01:21:50Z

[Term]
id: GO:0071890
name: bicarbonate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with bicarbonate (CHO3-) ions." [CHEBI:17544]
synonym: "hydrogencarbonate binding" EXACT [CHEBI:17544]
is_a: GO:0043168 ! anion binding
created_by: midori
creation_date: 2010-09-14T01:47:43Z

[Term]
id: GO:0071891
name: N-terminal peptidyl-proline dimethylation involved in translation
namespace: biological_process
def: "An N-terminal peptidyl-proline dimethylation process that contributes to translation." [GOC:mah]
is_a: GO:0018016 ! N-terminal peptidyl-proline dimethylation
intersection_of: GO:0018016 ! N-terminal peptidyl-proline dimethylation
intersection_of: part_of GO:0006412 ! translation
relationship: part_of GO:0006412 ! translation
created_by: midori
creation_date: 2010-09-14T02:19:40Z

[Term]
id: GO:0071892
name: thrombocyte activation
namespace: biological_process
def: "A cell activation process that occurs in thrombocytes and consists of a series of progressive, overlapping events including shape change, adhesiveness, and aggregation, which, when carried through to completion, lead to the formation of a stable hemostatic plug. Thrombocytes are nucleated cells found in non-mammalian vertebrates and are involved in hemostasis. They are the functional equivalent of the non-nucleated platelets found in mammals." [GOC:lb, GOC:mah, PMID:10606877, PMID:15634265, PMID:20180901]
synonym: "blood coagulation, thrombocyte activation" EXACT [GOC:mah]
is_a: GO:0001775 ! cell activation
relationship: part_of GO:0007596 ! blood coagulation
created_by: midori
creation_date: 2010-09-14T03:06:33Z

[Term]
id: GO:0071893
name: BMP signaling pathway involved in nephric duct formation
namespace: biological_process
def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to nephric duct formation." [GOC:mah, GOC:mtg_kidney_jan10]
synonym: "BMP signalling pathway involved in nephric duct formation" EXACT [GOC:mah]
is_a: GO:0030509 ! BMP signaling pathway
is_a: GO:0060994 ! regulation of transcription from RNA polymerase II promoter involved in kidney development
intersection_of: GO:0030509 ! BMP signaling pathway
intersection_of: part_of GO:0072179 ! nephric duct formation
relationship: part_of GO:0072179 ! nephric duct formation
created_by: midori
creation_date: 2010-09-14T03:14:59Z

[Term]
id: GO:0071894
name: histone H2B conserved C-terminal lysine ubiquitination
namespace: biological_process
def: "A histone ubiquitination process in which a ubiquitin monomer is added to a conserved lysine residue in the C-terminus of histone H2B. The conserved lysine residue is K119 in fission yeast, K123 in budding yeast, or K120 in mammals." [GOC:mah, GOC:vw]
synonym: "budding yeast H2B K123 ubiquitination" NARROW [GOC:vw]
synonym: "fission yeast H2B K119 ubiquitination" NARROW [GOC:vw]
synonym: "mammalian H2B K120 ubiquitination" NARROW [GOC:vw]
is_a: GO:0033523 ! histone H2B ubiquitination
created_by: midori
creation_date: 2010-09-14T03:43:46Z

[Term]
id: GO:0071895
name: odontoblast differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell of neural crest origin acquires the specialized features of an odontoblast, a cell on the outer surface of the dental pulp whose biological function is the creation of dentin." [GOC:sl, PMID:20425127]
is_a: GO:0060563 ! neuroepithelial cell differentiation
created_by: midori
creation_date: 2010-09-14T04:00:40Z

[Term]
id: GO:0071896
name: protein localization to adherens junction
namespace: biological_process
def: "Any process in which a protein is transported to, and/or maintained at the adherens junction." [GOC:BHF, GOC:mah]
synonym: "protein localisation to adherens junction" EXACT [GOC:mah]
is_a: GO:1902414 ! protein localization to cell junction
created_by: midori
creation_date: 2010-09-14T04:03:27Z

[Term]
id: GO:0071897
name: DNA biosynthetic process
namespace: biological_process
def: "The cellular DNA metabolic process resulting in the formation of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one." [GOC:mah]
subset: gosubset_prok
synonym: "DNA anabolism" EXACT [GOC:mah]
synonym: "DNA biosynthesis" EXACT [GOC:mah]
synonym: "DNA formation" EXACT [GOC:mah]
synonym: "DNA synthesis" EXACT [GOC:mah]
is_a: GO:0006259 ! DNA metabolic process
is_a: GO:0034645 ! cellular macromolecule biosynthetic process
is_a: GO:0034654 ! nucleobase-containing compound biosynthetic process
created_by: midori
creation_date: 2010-09-15T02:14:33Z

[Term]
id: GO:0071898
name: regulation of estrogen receptor binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of estrogen receptor binding, interacting selectively with a an estrogen receptor." [GOC:BHF, GOC:mah]
is_a: GO:0050789 ! regulation of biological process
is_a: GO:1900120 ! regulation of receptor binding
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: regulates GO:0030331 ! estrogen receptor binding
relationship: regulates GO:0030331 ! estrogen receptor binding
created_by: midori
creation_date: 2010-09-15T02:48:49Z

[Term]
id: GO:0071899
name: negative regulation of estrogen receptor binding
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of estrogen receptor binding, interacting selectively with an estrogen receptor." [GOC:BHF, GOC:mah]
is_a: GO:0071898 ! regulation of estrogen receptor binding
is_a: GO:1900121 ! negative regulation of receptor binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030331 ! estrogen receptor binding
relationship: negatively_regulates GO:0030331 ! estrogen receptor binding
created_by: midori
creation_date: 2010-09-15T02:51:10Z

[Term]
id: GO:0071900
name: regulation of protein serine/threonine kinase activity
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:mah]
is_a: GO:0045859 ! regulation of protein kinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004674 ! protein serine/threonine kinase activity
relationship: regulates GO:0004674 ! protein serine/threonine kinase activity
created_by: midori
creation_date: 2010-09-15T03:08:35Z

[Term]
id: GO:0071901
name: negative regulation of protein serine/threonine kinase activity
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:BHF, GOC:mah]
is_a: GO:0006469 ! negative regulation of protein kinase activity
is_a: GO:0071900 ! regulation of protein serine/threonine kinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004674 ! protein serine/threonine kinase activity
relationship: negatively_regulates GO:0004674 ! protein serine/threonine kinase activity
created_by: midori
creation_date: 2010-09-15T03:09:43Z

[Term]
id: GO:0071902
name: positive regulation of protein serine/threonine kinase activity
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:mah]
is_a: GO:0045860 ! positive regulation of protein kinase activity
is_a: GO:0071900 ! regulation of protein serine/threonine kinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004674 ! protein serine/threonine kinase activity
relationship: positively_regulates GO:0004674 ! protein serine/threonine kinase activity
created_by: midori
creation_date: 2010-09-15T03:09:57Z

[Term]
id: GO:0071903
name: protein N-linked N-acetylglucosaminylation via asparagine
namespace: biological_process
def: "A process of protein N-linked glycosylation via asparagine in which N-acetylglucosamine is added to the N4 of asparagine, forming an (S)-2-amino-4-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)amino-4-oxobutanoic acid residue." [GOC:pr, RESID:AA0151]
synonym: "protein amino acid N-linked N-acetylglucosaminylation via asparagine" EXACT [GOC:bf]
xref: RESID:AA0151
is_a: GO:0018279 ! protein N-linked glycosylation via asparagine
is_a: GO:1901135 ! carbohydrate derivative metabolic process
created_by: midori
creation_date: 2010-09-15T03:49:16Z

[Term]
id: GO:0071904
name: protein N-linked N-acetylgalactosaminylation via asparagine
namespace: biological_process
def: "A process of protein N-linked glycosylation via asparagine in which N-acetylgalactosamine is added to the N4 of asparagine, forming an (S)-2-amino-4-(2-acetamido-2-deoxy-beta-D-galactopyranosyl)amino-4-oxobutanoic acid residue." [GOC:pr, RESID:AA0420]
synonym: "protein amino acid N-linked N-acetylgalactosaminylation via asparagine" EXACT [GOC:bf]
xref: RESID:AA0420
is_a: GO:0018279 ! protein N-linked glycosylation via asparagine
is_a: GO:1901135 ! carbohydrate derivative metabolic process
created_by: midori
creation_date: 2010-09-15T03:52:28Z

[Term]
id: GO:0071905
name: protein N-linked glucosylation via asparagine
namespace: biological_process
def: "A process of protein N-linked glycosylation via asparagine in which glucose is added to the N4 of asparagine, forming an (S)-2-amino-4-(D-glucopyranosyl)amino-4-oxobutanoic acid residue." [GOC:pr, RESID:AA0421]
synonym: "protein amino acid N-linked glucosylation via asparagine" EXACT [GOC:bf]
xref: RESID:AA0421
is_a: GO:0018279 ! protein N-linked glycosylation via asparagine
created_by: midori
creation_date: 2010-09-15T03:54:25Z

[Term]
id: GO:0071906
name: CRD domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a CRD (context dependent regulatory) domain, a domain of about 130 residues that is the most divergent region among the LEF/TCF proteins." [GOC:yaf, PMID:19460168]
synonym: "context dependent regulatory domain binding" EXACT [GOC:mah]
is_a: GO:0019904 ! protein domain specific binding
created_by: midori
creation_date: 2010-09-21T04:08:53Z

[Term]
id: GO:0071907
name: determination of digestive tract left/right asymmetry
namespace: biological_process
def: "Determination of the asymmetric location of various parts of the digestive tract with respect to the left and right halves of the organism. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:cvs]
synonym: "determination of gut left/right asymmetry" EXACT [GOC:cvs]
synonym: "determination of left/right asymmetry of the digestive tract" EXACT [GOC:cvs]
is_a: GO:0007368 ! determination of left/right symmetry
relationship: part_of GO:0048565 ! digestive tract development
created_by: midori
creation_date: 2010-09-22T10:14:29Z

[Term]
id: GO:0071908
name: determination of intestine left/right asymmetry
namespace: biological_process
def: "Determination of the asymmetric location of the intestine loops with respect to the left and right halves of the organism." [GOC:cvs]
is_a: GO:0071907 ! determination of digestive tract left/right asymmetry
created_by: midori
creation_date: 2010-09-22T10:24:33Z

[Term]
id: GO:0071909
name: determination of stomach left/right asymmetry
namespace: biological_process
def: "Determination of the asymmetric location of the stomach with respect to the left and right halves of the organism." [GOC:cvs]
is_a: GO:0071907 ! determination of digestive tract left/right asymmetry
created_by: midori
creation_date: 2010-09-22T10:25:30Z

[Term]
id: GO:0071910
name: determination of liver left/right asymmetry
namespace: biological_process
def: "Determination of the asymmetric location of the liver with respect to the left and right halves of the organism." [GOC:cvs]
is_a: GO:0007368 ! determination of left/right symmetry
relationship: part_of GO:0001889 ! liver development
created_by: midori
creation_date: 2010-09-22T10:26:47Z

[Term]
id: GO:0071911
name: synchronous neurotransmitter secretion
namespace: biological_process
def: "Release of neurotransmitter at the synapse that lasts for just a few milliseconds after action potential invasion." [GOC:dsf, PMID:19477156, PMID:20643933]
is_a: GO:0007269 ! neurotransmitter secretion
created_by: midori
creation_date: 2010-09-22T01:38:36Z

[Term]
id: GO:0071912
name: asynchronous neurotransmitter secretion
namespace: biological_process
def: "Release of neurotransmitter at the synapse that persists for tens to hundreds of milliseconds after action potential invasion." [GOC:dsf, PMID:19477156, PMID:20643933]
is_a: GO:0007269 ! neurotransmitter secretion
created_by: midori
creation_date: 2010-09-22T01:45:35Z

[Term]
id: GO:0071913
name: citrate secondary active transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of citrate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mah, GOC:mtg_transport, GOC:vw]
subset: gosubset_prok
synonym: "citrate carrier activity" EXACT [GOC:mah]
is_a: GO:0005371 ! tricarboxylate secondary active transmembrane transporter activity
is_a: GO:0015137 ! citrate transmembrane transporter activity
created_by: midori
creation_date: 2010-09-22T02:18:54Z

[Term]
id: GO:0071914
name: prominosome
namespace: cellular_component
def: "An extracellular membrane-bounded vesicle that contains prominin proteins (in mouse Prom1/CD33 or Prom2) and are found in body fluids including ventricular fluid, saliva, urine and seminal fluid. In the ventricular fluid of the developing mouse brain two major classes of these particles have been observed (P2 particles of 500-1000 nm and P4 particles of 50-80 nm) which likely originate from microvilli, primary cilia and/or the midbody of neuroepithelial cells. The physiological role is not known." [GOC:vesicles, PMID:15976444, PMID:17109118, PMID:17283184]
synonym: "prominin-containing extracellular membrane vesicle" EXACT [GOC:curators]
is_a: GO:1903561 ! extracellular vesicle
created_by: midori
creation_date: 2010-09-24T09:24:36Z

[Term]
id: GO:0071915
name: protein-lysine lysylation
namespace: biological_process
def: "The addition of lysine group to a lysine residue in a protein, producing N6-(lysyl)-L-lysine. This modification is observed in, and is probably unique to, translation elongation factor P (EF-P)." [GOC:imk, GOC:jsg, PMID:20729861]
synonym: "protein amino acid lysylation" EXACT [GOC:imk]
is_a: GO:0018205 ! peptidyl-lysine modification
relationship: part_of GO:0072580 ! bacterial-type EF-P lysine modification
created_by: midori
creation_date: 2010-09-24T10:01:57Z

[Term]
id: GO:0071916
name: dipeptide transmembrane transporter activity
namespace: molecular_function
def: "Enables the directed movement of a dipeptide across a membrane into, out of or within a cell, or between cells. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond." [GOC:mah]
is_a: GO:0035673 ! oligopeptide transmembrane transporter activity
is_a: GO:0042936 ! dipeptide transporter activity
relationship: part_of GO:0035442 ! dipeptide transmembrane transport
created_by: midori
creation_date: 2010-09-24T10:32:36Z

[Term]
id: GO:0071917
name: triose-phosphate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a triose phosphate from one side of a membrane to the other." [GOC:mah, GOC:vw]
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity
relationship: part_of GO:0035436 ! triose phosphate transmembrane transport
created_by: midori
creation_date: 2010-09-24T10:35:26Z

[Term]
id: GO:0071918
name: urea transmembrane transport
namespace: biological_process
def: "The process in which urea, the water-soluble compound H2N-CO-NH2, is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "urea membrane transport" EXACT []
is_a: GO:0015840 ! urea transport
is_a: GO:0055085 ! transmembrane transport
created_by: midori
creation_date: 2010-09-24T10:41:36Z

[Term]
id: GO:0071919
name: G-quadruplex DNA formation
namespace: biological_process
def: "A DNA metabolic process that results in the formation of G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad or G-quartet. The stacking of several layers of G-quartets forms G-quadruplexes, in which one or more DNA single strands are assembled in parallel and/or antiparallel, with interactions that can be either intra- or intermolecular in nature." [GOC:sre, PMID:20098422]
synonym: "G quadruplex DNA formation" EXACT [GOC:mah]
synonym: "G quartet DNA formation" EXACT [GOC:mah]
synonym: "G-quartet DNA formation" EXACT [GOC:mah]
is_a: GO:0006259 ! DNA metabolic process
created_by: midori
creation_date: 2010-09-24T10:57:43Z

[Term]
id: GO:0071920
name: cleavage body
namespace: cellular_component
def: "A nuclear body that contains proteins involved in pre-mRNA 3'-end cleavage and polyadenylation, such as DDX1, CSTF2 and CPSFs, as well as the transcription factors TFIIE and TFIIF. Cleavage bodies are localized adjacent to Cajal bodies and are involved in mRNA3'-end processing." [PMID:10564273, PMID:11598190, PMID:8654386]
is_a: GO:0016604 ! nuclear body
created_by: midori
creation_date: 2010-09-28T10:35:05Z

[Term]
id: GO:0071921
name: cohesin localization to chromatin
namespace: biological_process
def: "A process in which a cohesin complex is transported to, or maintained at, a part of a chromosome that is organized into chromatin." [GOC:mah, PMID:10882066, PMID:17113138]
synonym: "cohesin association with chromatin" EXACT [GOC:lb]
synonym: "cohesin localisation to chromatin" EXACT [GOC:mah]
is_a: GO:0022402 ! cell cycle process
is_a: GO:0071168 ! protein localization to chromatin
is_a: GO:1902580 ! single-organism cellular localization
relationship: part_of GO:0007062 ! sister chromatid cohesion
created_by: midori
creation_date: 2010-09-28T11:07:26Z

[Term]
id: GO:0071922
name: regulation of cohesin localization to chromatin
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a process in which a cohesin complex is transported to, or maintained at, a part of a chromosome that is organized into chromatin." [GOC:lb, GOC:mah, PMID:17113138]
synonym: "regulation of cohesin association with chromatin" EXACT [GOC:lb]
synonym: "regulation of cohesin localisation to chromatin" EXACT [GOC:mah]
is_a: GO:0007063 ! regulation of sister chromatid cohesion
is_a: GO:1903827 ! regulation of cellular protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071921 ! cohesin localization to chromatin
relationship: regulates GO:0071921 ! cohesin localization to chromatin
created_by: midori
creation_date: 2010-09-28T11:13:35Z

[Term]
id: GO:0071923
name: negative regulation of cohesin localization to chromatin
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a process in which a cohesin complex is transported to, or maintained at, a part of a chromosome that is organized into chromatin." [GOC:lb, GOC:mah, PMID:17113138]
synonym: "negative regulation of cohesin association with chromatin" EXACT [GOC:lb]
synonym: "negative regulation of cohesin localisation to chromatin" EXACT [GOC:mah]
is_a: GO:0045875 ! negative regulation of sister chromatid cohesion
is_a: GO:0071922 ! regulation of cohesin localization to chromatin
is_a: GO:1903828 ! negative regulation of cellular protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071921 ! cohesin localization to chromatin
relationship: negatively_regulates GO:0071921 ! cohesin localization to chromatin
created_by: midori
creation_date: 2010-09-28T11:17:50Z

[Term]
id: GO:0071924
name: chemokine (C-C motif) ligand 22 production
namespace: biological_process
def: "The appearance of chemokine (C-C motif) ligand 22 (CCL22) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah, PMID:18832724]
synonym: "C-C motif chemokine 22 production" EXACT [GOC:mah]
synonym: "CCL-22 production" EXACT [GOC:mah]
synonym: "CCL22 production" EXACT [GOC:mah]
is_a: GO:0032602 ! chemokine production
created_by: midori
creation_date: 2010-09-28T11:33:13Z

[Term]
id: GO:0071925
name: thymic stromal lymphopoietin production
namespace: biological_process
def: "The appearance of thymic stromal lymphopoietin (TSLP) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah, PMID:17129180]
synonym: "TSLP production" EXACT [GOC:mah]
is_a: GO:0032602 ! chemokine production
created_by: midori
creation_date: 2010-09-28T11:38:55Z

[Term]
id: GO:0071926
name: endocannabinoid signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of an endocannabinoid binding to a cell surface receptor. The pathway proceeds with the receptor transmitting the signal to a heterotrimeric G-protein complex and ends with regulation of a downstream cellular process, e.g. transcription. Endocannabinoids are small molecules derived from arachidonic acid, anandamide (arachidonoylethanolamide) and 2-arachidonoylglycerol." [GOC:bf, GOC:mah, PMID:15550444]
synonym: "endocannabinoid signalling pathway" EXACT [GOC:mah]
is_a: GO:0038171 ! cannabinoid signaling pathway
created_by: midori
creation_date: 2010-09-28T11:52:03Z

[Term]
id: GO:0071927
name: octopamine signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of octopamine binding to a cell surface receptor." [GOC:mah, PMID:15355245]
synonym: "octopamine signalling pathway" EXACT [GOC:mah]
is_a: GO:0007211 ! octopamine or tyramine signaling pathway
created_by: midori
creation_date: 2010-09-28T01:18:57Z

[Term]
id: GO:0071928
name: tyramine signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of tyramine binding to a cell surface receptor." [GOC:mah, PMID:15355245]
synonym: "tyramine signalling pathway" EXACT [GOC:mah]
is_a: GO:0007211 ! octopamine or tyramine signaling pathway
created_by: midori
creation_date: 2010-09-28T01:20:10Z

[Term]
id: GO:0071929
name: alpha-tubulin acetylation
namespace: biological_process
def: "The addition of an acetyl group to the lysine 40 residue of alpha-tubulin." [GOC:kmv, PMID:17786050]
is_a: GO:0018393 ! internal peptidyl-lysine acetylation
created_by: midori
creation_date: 2010-09-28T01:46:38Z

[Term]
id: GO:0071930
name: negative regulation of transcription involved in G1/S transition of mitotic cell cycle
namespace: biological_process
def: "Any process that stop, prevents or decreases transcription as part of the G1/S transition of the mitotic cell cycle." [GOC:mah, GOC:vw]
synonym: "negative regulation of transcription from RNA polymerase II promoter during G1/S phase of mitotic cell cycle" RELATED [GOC:mah]
synonym: "negative regulation of transcription from RNA polymerase II promoter involved in G1/S transition of mitotic cell cycle" EXACT [GOC:mah]
is_a: GO:0000083 ! regulation of transcription involved in G1/S transition of mitotic cell cycle
is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0045892 ! negative regulation of transcription, DNA-templated
intersection_of: part_of GO:0000082 ! G1/S transition of mitotic cell cycle
relationship: part_of GO:0000082 ! G1/S transition of mitotic cell cycle
created_by: midori
creation_date: 2010-09-29T11:12:11Z

[Term]
id: GO:0071931
name: positive regulation of transcription involved in G1/S transition of mitotic cell cycle
namespace: biological_process
def: "Any process that activates or increases transcription as part of the G1/S transition of the mitotic cell cycle." [GOC:mah, GOC:vw]
synonym: "positive regulation of transcription from RNA polymerase II promoter during G1/S phase of mitotic cell cycle" RELATED [GOC:mah]
synonym: "positive regulation of transcription from RNA polymerase II promoter involved in G1/S transition of mitotic cell cycle" EXACT [GOC:mah]
is_a: GO:0000083 ! regulation of transcription involved in G1/S transition of mitotic cell cycle
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0045893 ! positive regulation of transcription, DNA-templated
intersection_of: part_of GO:0000082 ! G1/S transition of mitotic cell cycle
relationship: part_of GO:0000082 ! G1/S transition of mitotic cell cycle
created_by: midori
creation_date: 2010-09-29T11:15:34Z

[Term]
id: GO:0071932
name: replication fork reversal
namespace: biological_process
def: "Replication fork processing that involves the unwinding of blocked forks to form four-stranded structures resembling Holliday junctions, which are subsequently resolved." [PMID:19406929]
is_a: GO:0031297 ! replication fork processing
created_by: midori
creation_date: 2010-09-29T02:34:22Z

[Term]
id: GO:0071933
name: Arp2/3 complex binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an Arp2/3 complex, a protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5)." [GOC:mah]
is_a: GO:0032403 ! protein complex binding
created_by: midori
creation_date: 2010-09-29T02:48:41Z

[Term]
id: GO:0071934
name: thiamine transmembrane transport
namespace: biological_process
def: "The directed movement of thiamine across a membrane into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "thiamin transmembrane transport" EXACT [GOC:mah]
synonym: "thiamine membrane transport" EXACT []
synonym: "vitamin B1 transmembrane transport" EXACT [GOC:mah]
is_a: GO:0015888 ! thiamine transport
is_a: GO:0035461 ! vitamin transmembrane transport
is_a: GO:0072531 ! pyrimidine-containing compound transmembrane transport
created_by: midori
creation_date: 2010-09-29T02:59:39Z

[Term]
id: GO:0071935
name: octopamine signaling pathway involved in response to food
namespace: biological_process
def: "The series of molecular signals initiated by binding of octopamine to a receptor on the surface of the target cell that contributes to a response to a food stimulus." [GOC:mah, PMID:19609300]
synonym: "octopamine signalling pathway involved in response to food" EXACT [GOC:mah]
is_a: GO:0071927 ! octopamine signaling pathway
intersection_of: GO:0071927 ! octopamine signaling pathway
intersection_of: part_of GO:0032094 ! response to food
relationship: part_of GO:0032094 ! response to food
created_by: midori
creation_date: 2010-09-30T11:55:59Z

[Term]
id: GO:0071936
name: coreceptor activity involved in Wnt signaling pathway
namespace: molecular_function
def: "In cooperation with a primary Wnt receptor, initiating a change in cell activity through the Wnt signaling pathway." [GOC:BHF, GOC:mah]
synonym: "coreceptor activity involved in Wnt receptor signaling pathway" EXACT []
synonym: "coreceptor activity involved in Wnt receptor signalling pathway" EXACT [GOC:mah]
synonym: "coreceptor activity involved in Wnt-activated signaling pathway" EXACT [GOC:signaling]
synonym: "Wnt co-receptor activity" EXACT [GOC:bf]
is_a: GO:0015026 ! coreceptor activity
intersection_of: GO:0015026 ! coreceptor activity
intersection_of: part_of GO:0016055 ! Wnt signaling pathway
relationship: part_of GO:0016055 ! Wnt signaling pathway
created_by: midori
creation_date: 2010-09-30T03:54:34Z

[Term]
id: GO:0071938
name: vitamin A transport
namespace: biological_process
def: "The directed movement any form of vitamin A into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Vitamin A is any of several retinoid derivatives of beta-carotene, primarily retinol, retinal, or retinoic acid." [GOC:mah, PMID:16011460, PMID:1924551]
synonym: "vitamin A uptake and transport" RELATED [GOC:rs]
is_a: GO:0046865 ! terpenoid transport
is_a: GO:0051180 ! vitamin transport
created_by: midori
creation_date: 2010-09-30T04:15:10Z

[Term]
id: GO:0071939
name: vitamin A import
namespace: biological_process
def: "The directed movement of vitamin A into a cell or organelle. Vitamin A is any of several retinoid derivatives of beta-carotene, primarily retinol, retinal, or retinoic acid." [GOC:mah, PMID:16011460, PMID:1924551]
synonym: "vitamin A uptake" EXACT [GOC:mah, GOC:rs]
is_a: GO:0035461 ! vitamin transmembrane transport
is_a: GO:0071938 ! vitamin A transport
created_by: midori
creation_date: 2010-09-30T04:36:22Z

[Term]
id: GO:0071940
name: fungal-type cell wall assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a fungal-type cell wall." [GOC:mah, GOC:vw, PMID:19646873]
synonym: "fungal-type cell wall formation" RELATED [GOC:mah]
is_a: GO:0031505 ! fungal-type cell wall organization
is_a: GO:0070726 ! cell wall assembly
relationship: part_of GO:0009272 ! fungal-type cell wall biogenesis
created_by: midori
creation_date: 2010-09-30T04:59:36Z

[Term]
id: GO:0071941
name: nitrogen cycle metabolic process
namespace: biological_process
def: "A nitrogen compound metabolic process that contributes to the nitrogen cycle. The nitrogen cycle is a series of metabolic pathways by which nitrogen is converted between various forms and redox states; it encompasses pathways in which nitrogen is acted upon directly, such as nitrification, denitrification, nitrogen fixation, and mineralization." [GOC:mah, PMID:16675690, Wikipedia:Nitrogen_cycle]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pombe
xref: Wikipedia:Nitrogen_cycle
is_a: GO:0006807 ! nitrogen compound metabolic process
created_by: midori
creation_date: 2010-09-30T05:21:03Z

[Term]
id: GO:0071942
name: XPC complex
namespace: cellular_component
def: "A nucleotide-excision repair complex that is involved in damage sensing during global genome nucleotide excision repair (GG-NER). It is part of the pre-incision (or initial recognition) complex bound to sites of DNA damage. In human, it is composed of XPC, RAD23B and CETN2." [PMID:11279143, PMID:15964821, PMID:19941824]
is_a: GO:0000109 ! nucleotide-excision repair complex
created_by: midori
creation_date: 2010-10-01T11:09:36Z

[Term]
id: GO:0071943
name: Myc-Max complex
namespace: cellular_component
def: "A transcription factor complex that consists of a heterodimer of the bHLH-ZIP proteins Myc and Max." [GOC:cna, PMID:16620027, PMID:16620031, PMID:20170194]
is_a: GO:0090575 ! RNA polymerase II transcription factor complex
created_by: midori
creation_date: 2010-10-01T11:56:17Z

[Term]
id: GO:0071944
name: cell periphery
namespace: cellular_component
def: "The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures." [GOC:mah]
is_a: GO:0044464 ! cell part
created_by: midori
creation_date: 2010-10-04T01:51:47Z

[Term]
id: GO:0071945
name: regulation of bacterial-type flagellum-dependent cell motility by regulation of motor speed
namespace: biological_process
def: "A process that modulates flagellum-dependent motility in bacteria by modulating the speed or direction of rotation of a rotary flagellar motor, mediated by interactions between the braking protein." [GOC:cilia, GOC:jl, PMID:20371342]
synonym: "regulation of bacterial-type flagellar cell motility by regulation of motor speed" RELATED []
synonym: "regulation of bacterial-type flagellum cell motility by regulation of motor speed" EXACT []
synonym: "regulation of flagellar cell motility by regulation of motor speed" BROAD []
is_a: GO:1902021 ! regulation of bacterial-type flagellum-dependent cell motility
created_by: midori
creation_date: 2010-10-05T04:10:27Z

[Term]
id: GO:0071946
name: cis-acting DNA replication termination
namespace: biological_process
def: "A DNA replication termination process that is initiated by protein binding to a binding site on the same chromosome, but remote from the termination site, via DNA looping or chromosome kissing." [GOC:vw, PMID:20850009]
synonym: "cis acting DNA replication termination" EXACT [GOC:vw]
is_a: GO:0071170 ! site-specific DNA replication termination
created_by: midori
creation_date: 2010-10-06T01:08:48Z

[Term]
id: GO:0071947
name: protein deubiquitination involved in ubiquitin-dependent protein catabolic process
namespace: biological_process
def: "The removal of one or more ubiquitin groups from a protein as part of a process of ubiquitin-dependent protein catabolism." [GOC:mah]
is_a: GO:0016579 ! protein deubiquitination
is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process
intersection_of: GO:0016579 ! protein deubiquitination
intersection_of: part_of GO:0006511 ! ubiquitin-dependent protein catabolic process
relationship: part_of GO:0006511 ! ubiquitin-dependent protein catabolic process
created_by: midori
creation_date: 2010-10-06T02:06:10Z

[Term]
id: GO:0071948
name: activation-induced B cell apoptotic process
namespace: biological_process
def: "B cell apoptotic process that occurs upon engagement of either the B cell receptor or CD40. Engagement of either receptor, but not both, leads to expression of fas or related receptors that make the B cell susceptible to fas-ligand mediated death." [GOC:mtg_apoptosis, GOC:tfm, PMID:11032170, PMID:19300454]
synonym: "activated B cell apoptosis" BROAD [GOC:tfm]
synonym: "activation-induced B cell apoptosis" NARROW []
synonym: "activation-induced B-cell apoptosis" EXACT [GOC:tfm]
synonym: "activation-induced cell death of B cells" EXACT [GOC:tfm]
synonym: "activation-induced cell death of B lymphocytes" EXACT [GOC:tfm]
synonym: "activation-induced cell death of B-cells" EXACT [GOC:tfm]
synonym: "activation-induced cell death of B-lymphocytes" EXACT [GOC:tfm]
synonym: "AICD" BROAD [GOC:tfm]
synonym: "antigen-driven apoptosis" BROAD [GOC:tfm]
is_a: GO:0001783 ! B cell apoptotic process
created_by: midori
creation_date: 2010-10-06T02:47:46Z

[Term]
id: GO:0071949
name: FAD binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]
subset: gosubset_prok
synonym: "oxidized flavin adenine dinucleotide binding" EXACT [GOC:mah]
synonym: "oxidized flavine-adenine dinucleotide binding" EXACT [GOC:mah]
is_a: GO:0050660 ! flavin adenine dinucleotide binding
created_by: midori
creation_date: 2010-10-07T12:30:28Z

[Term]
id: GO:0071950
name: FADH2 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the reduced form, FADH2, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]
subset: gosubset_prok
synonym: "reduced flavin adenine dinucleotide binding" EXACT [GOC:mah]
synonym: "reduced flavine-adenine dinucleotide binding" EXACT [GOC:mah]
is_a: GO:0050660 ! flavin adenine dinucleotide binding
created_by: midori
creation_date: 2010-10-07T12:31:34Z

[Term]
id: GO:0071951
name: conversion of methionyl-tRNA to N-formyl-methionyl-tRNA
namespace: biological_process
def: "The modification process that results in the conversion of methionine charged on a tRNA(fMet) to N-formyl-methionine-tRNA(fMet)." [GOC:jsg, PMID:5337045]
is_a: GO:0019988 ! charged-tRNA amino acid modification
created_by: midori
creation_date: 2010-10-08T11:54:38Z

[Term]
id: GO:0071952
name: conversion of O-phosphoseryl-tRNA to cysteinyl-tRNA
namespace: biological_process
def: "The modification process that results in the conversion of O-phosphoserine charged on a tRNA(Cys) to cysteinyl-tRNA." [GOC:jsg, PMID:17351629, PMID:18559341]
comment: Note that this process has been observed in some archeal and bacterial species.
subset: gosubset_prok
is_a: GO:0019988 ! charged-tRNA amino acid modification
created_by: midori
creation_date: 2010-10-08T12:02:00Z

[Term]
id: GO:0071953
name: elastic fiber
namespace: cellular_component
def: "An extracellular matrix part that consists of an insoluble core of polymerized tropoelastin monomers and a surrounding mantle of microfibrils. Elastic fibers provide elasticity and recoiling to tissues and organs, and maintain structural integrity against mechanical strain." [GOC:BHF, GOC:mah, PMID:20236620]
synonym: "elastic fibre" EXACT [GOC:mah]
synonym: "elastin fiber" EXACT [GOC:BHF]
is_a: GO:0044420 ! extracellular matrix component
created_by: midori
creation_date: 2010-10-11T11:44:57Z

[Term]
id: GO:0071954
name: chemokine (C-C motif) ligand 11 production
namespace: biological_process
def: "The appearance of chemokine (C-C motif) ligand 11 (CCL11, also known as eotaxin-1) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah, PMID:9600955]
synonym: "C-C motif chemokine 11 production" EXACT [GOC:mah]
synonym: "CCL-11 production" EXACT [GOC:mah]
synonym: "CCL11 production" EXACT [GOC:mah]
synonym: "eotaxin production" BROAD [GOC:mah]
synonym: "eotaxin-1 production" EXACT [GOC:mah]
is_a: GO:0032602 ! chemokine production
created_by: midori
creation_date: 2010-10-08T12:10:34Z

[Term]
id: GO:0071955
name: recycling endosome to Golgi transport
namespace: biological_process
def: "The directed movement of substances from recycling endosomes to the Golgi." [GOC:lb]
is_a: GO:0042147 ! retrograde transport, endosome to Golgi
is_a: GO:0048193 ! Golgi vesicle transport
created_by: midori
creation_date: 2010-10-08T01:19:00Z

[Term]
id: GO:0071957
name: old mitotic spindle pole body
namespace: cellular_component
def: "The spindle pole body that exists in a cell prior to spindle pole body duplication. An old spindle pole body segregates to the daughter cell upon mitosis, and lacks active proteins involved in signaling exit from mitosis." [GOC:mah, GOC:vw, PMID:15132994]
synonym: "old SPB" EXACT [GOC:mah]
is_a: GO:0044732 ! mitotic spindle pole body
created_by: midori
creation_date: 2011-06-01T02:32:10Z

[Term]
id: GO:0071958
name: new mitotic spindle pole body
namespace: cellular_component
def: "The spindle pole body that is formed by spindle pole body duplication, and to which proteins involved in mitotic exit signaling (for example, the septation initiation network in fission yeast) localize." [GOC:mah, GOC:vw, PMID:15132994]
synonym: "new SPB" EXACT [GOC:mah]
is_a: GO:0044732 ! mitotic spindle pole body
created_by: midori
creation_date: 2011-06-01T02:34:34Z

[Term]
id: GO:0071959
name: maintenance of mitotic sister chromatid cohesion, arms
namespace: biological_process
def: "The process in which the association between sister chromatids of a replicated chromosome along the length of the chromosome arms, is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a mitotic cell cycle." [GOC:mah, PMID:1708436]
synonym: "maintenance of mitotic sister chromatin cohesion along arms" EXACT [GOC:mah]
synonym: "maintenance of sister chromatin cohesion along arms at mitosis" EXACT [GOC:mah]
is_a: GO:0034088 ! maintenance of mitotic sister chromatid cohesion
relationship: part_of GO:0071961 ! mitotic sister chromatid cohesion, arms
created_by: midori
creation_date: 2011-06-01T04:08:43Z

[Term]
id: GO:0071960
name: maintenance of mitotic sister chromatid cohesion, centromeric
namespace: biological_process
def: "The process in which the association between sister chromatids of a replicated chromosome along the length of the centromeric region is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a mitotic cell cycle." [GOC:mah, PMID:1708436]
synonym: "maintenance of centromeric mitotic sister chromatin cohesion" EXACT [GOC:mah]
synonym: "maintenance of mitotic sister chromatin cohesion at centromere" EXACT [GOC:mah]
synonym: "maintenance of sister chromatin cohesion at centromere at mitosis" EXACT [GOC:mah]
is_a: GO:0034088 ! maintenance of mitotic sister chromatid cohesion
relationship: part_of GO:0071962 ! mitotic sister chromatid cohesion, centromeric
created_by: midori
creation_date: 2011-06-01T04:10:59Z

[Term]
id: GO:0071961
name: mitotic sister chromatid cohesion, arms
namespace: biological_process
def: "The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the length of the chromosome arms during mitosis." [GOC:mah]
synonym: "mitotic sister chromatid cohesion along arms" EXACT [GOC:mah]
synonym: "sister chromatid cohesion along arms at mitosis" EXACT [GOC:mah]
is_a: GO:0007064 ! mitotic sister chromatid cohesion
created_by: midori
creation_date: 2011-06-02T11:21:13Z

[Term]
id: GO:0071962
name: mitotic sister chromatid cohesion, centromeric
namespace: biological_process
def: "The cell cycle process in which centromeres of sister chromatids are joined during mitosis." [GOC:mah]
synonym: "centromeric mitotic sister chromatin cohesion" EXACT [GOC:mah]
synonym: "mitotic sister chromatid cohesion at centromere" EXACT [GOC:mah]
synonym: "sister chromatid cohesion at centromere at mitosis" EXACT [GOC:mah]
is_a: GO:0007064 ! mitotic sister chromatid cohesion
is_a: GO:0070601 ! centromeric sister chromatid cohesion
created_by: midori
creation_date: 2011-06-02T11:24:17Z

[Term]
id: GO:0071963
name: establishment or maintenance of cell polarity regulating cell shape
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of a polarized intracellular organization or cell growth patterns that regulate the shape of a cell." [GOC:mah]
is_a: GO:0007163 ! establishment or maintenance of cell polarity
is_a: GO:0008360 ! regulation of cell shape
created_by: midori
creation_date: 2011-06-21T03:47:21Z

[Term]
id: GO:0071964
name: establishment of cell polarity regulating cell shape
namespace: biological_process
def: "Any cellular process that results in the specification or formation of a polarized intracellular organization or cell growth pattern that regulates the shape of a cell." [GOC:mah]
is_a: GO:0030010 ! establishment of cell polarity
is_a: GO:0071963 ! establishment or maintenance of cell polarity regulating cell shape
created_by: midori
creation_date: 2011-06-22T03:10:08Z

[Term]
id: GO:0071965
name: multicellular organismal locomotion
namespace: biological_process
def: "Locomotion in a multicellular organism, i.e. self-propelled movement of a multicellular organism from one location to another." [GOC:mah]
is_a: GO:0040011 ! locomotion
is_a: GO:0050879 ! multicellular organismal movement
created_by: midori
creation_date: 2010-10-14T10:34:35Z

[Term]
id: GO:0071966
name: fungal-type cell wall polysaccharide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the polysaccharides which make up the fungal-type cell wall." [GOC:mah]
is_a: GO:0010383 ! cell wall polysaccharide metabolic process
relationship: part_of GO:0071852 ! fungal-type cell wall organization or biogenesis
created_by: midori
creation_date: 2010-10-14T11:56:47Z

[Term]
id: GO:0071967
name: lipopolysaccharide core heptosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: glucosyl-heptosyl2-KDO2-lipid A-phosphate + ADP-L-glycero-beta-D-manno-heptose = glucosyl-heptosyl3-KDO2-lipid A-phosphate + ADP + H+." [MetaCyc:RXN0-5122]
subset: gosubset_prok
synonym: "LPS core heptosyltransferase activity" EXACT [MetaCyc:LIPA-CORESYN-PWY]
xref: MetaCyc:RXN0-5122
is_a: GO:0008920 ! lipopolysaccharide heptosyltransferase activity
created_by: midori
creation_date: 2010-10-14T05:13:31Z

[Term]
id: GO:0071968
name: lipid A-core heptosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: galactosyl-glucosyl3-heptosyl3-KDO2-lipid A-bisphosphate + ADP-L-glycero-beta-D-manno-heptose = lipid A-core + ADP + H+." [MetaCyc:RXN0-5127]
subset: gosubset_prok
xref: MetaCyc:RXN0-5127
is_a: GO:0008920 ! lipopolysaccharide heptosyltransferase activity
created_by: midori
creation_date: 2010-10-14T05:15:22Z

[Term]
id: GO:0071969
name: fungal-type cell wall (1->3)-beta-D-glucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in the walls of ascospores." [GOC:mah]
synonym: "fungal-type cell wall 1,3-beta-D-glucan metabolic process" EXACT []
synonym: "fungal-type cell wall 1,3-beta-glucan metabolism" EXACT [GOC:mah]
synonym: "fungal-type cell wall beta-1,3 glucan metabolic process" EXACT [GOC:mah]
synonym: "fungal-type cell wall beta-1,3 glucan metabolism" EXACT [GOC:mah]
is_a: GO:0034407 ! cell wall (1->3)-beta-D-glucan metabolic process
is_a: GO:0070879 ! fungal-type cell wall beta-glucan metabolic process
created_by: midori
creation_date: 2010-10-18T03:25:38Z

[Term]
id: GO:0071970
name: fungal-type cell wall (1->3)-beta-D-glucan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in the walls of ascospores." [GOC:mah]
synonym: "fungal-type cell wall 1,3-beta-D-glucan biosynthetic process" EXACT []
synonym: "fungal-type cell wall 1,3-beta-glucan anabolism" EXACT [GOC:mah]
synonym: "fungal-type cell wall 1,3-beta-glucan biosynthesis" EXACT [GOC:mah]
synonym: "fungal-type cell wall 1,3-beta-glucan formation" EXACT [GOC:mah]
synonym: "fungal-type cell wall 1,3-beta-glucan synthesis" EXACT [GOC:mah]
synonym: "fungal-type cell wall beta-1,3-glucan anabolism" EXACT [GOC:mah]
synonym: "fungal-type cell wall beta-1,3-glucan biosynthesis" EXACT [GOC:mah]
synonym: "fungal-type cell wall beta-1,3-glucan biosynthetic process" EXACT [GOC:mah]
synonym: "fungal-type cell wall beta-1,3-glucan formation" EXACT [GOC:mah]
synonym: "fungal-type cell wall beta-1,3-glucan synthesis" EXACT [GOC:mah]
is_a: GO:0034411 ! cell wall (1->3)-beta-D-glucan biosynthetic process
is_a: GO:0070880 ! fungal-type cell wall beta-glucan biosynthetic process
is_a: GO:0071969 ! fungal-type cell wall (1->3)-beta-D-glucan metabolic process
created_by: midori
creation_date: 2010-10-18T03:25:56Z

[Term]
id: GO:0071971
name: extracellular exosome assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an extracellular vesicular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane." [GOC:mah, GOC:tfm, PMID:19442504]
synonym: "extracellular vesicular exosome assembly" EXACT [GOC:vesicles]
is_a: GO:0016050 ! vesicle organization
is_a: GO:0070925 ! organelle assembly
created_by: midori
creation_date: 2010-10-18T03:44:18Z

[Term]
id: GO:0071972
name: peptidoglycan L,D-transpeptidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 a peptidoglycan dimer (tetrapeptide) + 3 H2O = a peptidoglycan tetramer with L,D cross-links (L-Lys-D-Asn-L-Lys) + di-trans,poly-cis-undecaprenyl diphosphate + 4 D-alanine." [MetaCyc:RXN-11349]
xref: MetaCyc:RXN-11349
is_a: GO:0004185 ! serine-type carboxypeptidase activity
created_by: midori
creation_date: 2010-10-18T04:36:19Z

[Term]
id: GO:0071973
name: bacterial-type flagellum-dependent cell motility
namespace: biological_process
def: "Cell motility due to the motion of one or more bacterial-type flagella. A bacterial-type flagellum is a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope." [GOC:cilia, GOC:krc, GOC:mah]
subset: gosubset_prok
synonym: "bacterial-type flagellar cell motility" RELATED []
synonym: "flagellin-based flagellar cell motility" EXACT [GOC:mah]
is_a: GO:0097588 ! archaeal or bacterial-type flagellum-dependent cell motility
created_by: midori
creation_date: 2010-10-21T12:00:53Z

[Term]
id: GO:0071975
name: cell swimming
namespace: biological_process
def: "Cell motility that results in the smooth movement of a cell through a liquid medium." [PMID:18461074]
subset: gosubset_prok
synonym: "cell swimming motility" EXACT [GOC:mah]
is_a: GO:0048870 ! cell motility
created_by: midori
creation_date: 2010-10-21T02:31:34Z

[Term]
id: GO:0071976
name: cell gliding
namespace: biological_process
def: "Cell motility that results in the smooth movement of a cell along a solid surface." [PMID:18461074]
subset: gosubset_prok
synonym: "cell gliding motility" EXACT [GOC:mah]
is_a: GO:0048870 ! cell motility
created_by: midori
creation_date: 2010-10-21T02:33:24Z

[Term]
id: GO:0071977
name: bacterial-type flagellum-dependent swimming motility
namespace: biological_process
def: "Bacterial-type flagellum-dependent cell motility that results in the smooth movement of a cell through a liquid medium." [GOC:cilia, PMID:18461074]
subset: gosubset_prok
synonym: "bacterial-type flagellar swimming motility" RELATED []
synonym: "bacterial-type flagellum-mediated cell swimming" EXACT [GOC:mah]
is_a: GO:0071973 ! bacterial-type flagellum-dependent cell motility
is_a: GO:0071975 ! cell swimming
created_by: midori
creation_date: 2010-10-21T02:58:51Z

[Term]
id: GO:0071978
name: bacterial-type flagellum-dependent swarming motility
namespace: biological_process
def: "Bacterial-type flagellum-dependent cell motility in which the action of numerous flagella results in the smooth movement of a group of cells along a solid surface. Swarming motility is observed in groups of bacteria." [GOC:cilia, PMID:14527279, PMID:18461074]
subset: gosubset_prok
synonym: "bacterial-type flagellar swarming motility" RELATED []
synonym: "bacterial-type flagellum-mediated cell swarming" EXACT [GOC:mah]
is_a: GO:0071973 ! bacterial-type flagellum-dependent cell motility
created_by: midori
creation_date: 2010-10-21T03:00:14Z

[Term]
id: GO:0071979
name: cytoskeleton-mediated cell swimming
namespace: biological_process
def: "Cell motility in which contractile cytoskeletal elements alter cell shape, resulting in the smooth movement of a cell through a liquid medium." [PMID:18461074]
subset: gosubset_prok
synonym: "cytoskeleton-mediated swimming motility" EXACT [GOC:mah]
is_a: GO:0071975 ! cell swimming
created_by: midori
creation_date: 2010-10-21T03:02:36Z

[Term]
id: GO:0071980
name: cell surface adhesin-mediated gliding motility
namespace: biological_process
def: "Cell gliding that results from the actions of cell surface adhesin proteins that are propelled by membrane motor proteins." [PMID:18461074]
subset: gosubset_prok
is_a: GO:0071976 ! cell gliding
created_by: midori
creation_date: 2010-10-21T03:03:44Z

[Term]
id: GO:0071981
name: exit from diapause
namespace: biological_process
def: "The dormancy process that results in exit from diapause. Diapause is a neurohormonally mediated, dynamic state of low metabolic activity. Associated characteristics of this form of dormancy include reduced morphogenesis, increased resistance to environmental extremes, and altered or reduced behavioral activity. Full expression develops in a species-specific manner, usually in response to a number of environmental stimuli that precede unfavorable conditions. Once diapause has begun, metabolic activity is suppressed even if conditions favorable for development prevail. Once initiated, only certain stimuli are capable of releasing the organism from this state, and this characteristic is essential in distinguishing diapause from hibernation." [GOC:mah]
is_a: GO:0022611 ! dormancy process
is_a: GO:0044767 ! single-organism developmental process
created_by: midori
creation_date: 2010-10-21T04:45:40Z

[Term]
id: GO:0071982
name: maintenance of diapause
namespace: biological_process
def: "The dormancy process that results an organism remaining in diapause. Diapause is a neurohormonally mediated, dynamic state of low metabolic activity. Associated characteristics of this form of dormancy include reduced morphogenesis, increased resistance to environmental extremes, and altered or reduced behavioral activity. Full expression develops in a species-specific manner, usually in response to a number of environmental stimuli that precede unfavorable conditions. Once diapause has begun, metabolic activity is suppressed even if conditions favorable for development prevail. Once initiated, only certain stimuli are capable of releasing the organism from this state, and this characteristic is essential in distinguishing diapause from hibernation." [GOC:mah]
is_a: GO:0022611 ! dormancy process
is_a: GO:0044767 ! single-organism developmental process
created_by: midori
creation_date: 2010-10-21T04:46:32Z

[Term]
id: GO:0071983
name: exit from reproductive diapause
namespace: biological_process
def: "The dormancy process that results in exit from reproductive diapause. Reproductive diapause is a form of diapause where the organism itself will remain fully active, including feeding and other routine activities, but the reproductive organs experience a tissue-specific reduction in metabolism, with characteristic triggering and releasing stimuli." [GOC:mah]
is_a: GO:0071981 ! exit from diapause
created_by: midori
creation_date: 2010-10-21T04:48:12Z

[Term]
id: GO:0071984
name: maintenance of reproductive diapause
namespace: biological_process
def: "The dormancy process that results an organism remaining in reproductive diapause. Reproductive diapause is a form of diapause where the organism itself will remain fully active, including feeding and other routine activities, but the reproductive organs experience a tissue-specific reduction in metabolism, with characteristic triggering and releasing stimuli." [GOC:mah]
is_a: GO:0071982 ! maintenance of diapause
created_by: midori
creation_date: 2010-10-21T04:49:28Z

[Term]
id: GO:0071985
name: multivesicular body sorting pathway
namespace: biological_process
def: "A vesicle-mediated transport process in which transmembrane proteins are ubiquitylated to facilitate their entry into luminal vesicles of multivesicular bodies (MVBs); upon subsequent fusion of MVBs with lysosomes or vacuoles, the cargo proteins are degraded." [GOC:mah, PMID:17603537]
is_a: GO:0016192 ! vesicle-mediated transport
is_a: GO:0044765 ! single-organism transport
created_by: midori
creation_date: 2010-10-22T12:04:16Z

[Term]
id: GO:0071986
name: Ragulator complex
namespace: cellular_component
def: "A protein complex that contains MAPKSP1 (MP1, Map2k1ip1), ROBLD3 (p14, Mapbpip), C11orf59 (p18), LAMTOR4 and LAMTOR5. The complex is anchored to lipid rafts in late endosome membranes via C11orf59, recruits mTORC1 to lysosomal membranes in amino acid signaling to mTORC1, constitutes a guanine nucleotide exchange factor (GEF) for the Rag GTPases, and is also involved in ERK/MAPK signaling." [GOC:lb, PMID:19177150, PMID:20381137, PMID:22980980]
synonym: "MAPKSP1/ROBLD3/C11orf59 complex" EXACT [GOC:mah]
is_a: GO:0044440 ! endosomal part
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0031902 ! late endosome membrane
relationship: part_of GO:0045121 ! membrane raft
created_by: midori
creation_date: 2010-10-22T02:42:13Z

[Term]
id: GO:0071987
name: WD40-repeat domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a WD40 repeat domain of a protein. The WD40 repeat is a short structural motif of approximately 40 amino acids, often terminating in a tryptophan-aspartic acid (W-D) dipeptide. Several of these repeats are combined to form a type of protein domain called the WD domain." [GOC:yaf, InterPro:IPR017986]
synonym: "beta-transducin repeat domain binding" EXACT [GOC:yaf]
synonym: "WD domain binding" EXACT [GOC:yaf]
is_a: GO:0019904 ! protein domain specific binding
created_by: midori
creation_date: 2010-10-22T02:53:29Z

[Term]
id: GO:0071988
name: protein localization to spindle pole body
namespace: biological_process
def: "A process in which a protein is transported to, or maintained at, the spindle pole body." [GOC:mah]
synonym: "protein localisation to spindle pole body" EXACT [GOC:mah]
is_a: GO:0072698 ! protein localization to microtubule cytoskeleton
created_by: midori
creation_date: 2010-10-25T10:56:33Z

[Term]
id: GO:0071989
name: establishment of protein localization to spindle pole body
namespace: biological_process
def: "The directed movement of a protein to a specific location at the spindle pole body." [GOC:mah]
synonym: "establishment of protein localisation to spindle pole body" EXACT [GOC:mah]
is_a: GO:0072594 ! establishment of protein localization to organelle
relationship: part_of GO:0071988 ! protein localization to spindle pole body
created_by: midori
creation_date: 2010-10-25T11:01:17Z

[Term]
id: GO:0071990
name: maintenance of protein location in spindle pole body
namespace: biological_process
def: "Any process in which a protein is maintained in a specific location at the spindle pole body, and is prevented from moving elsewhere." [GOC:mah]
synonym: "maintenance of protein location at spindle pole body" EXACT [GOC:curators]
is_a: GO:0022402 ! cell cycle process
is_a: GO:0072595 ! maintenance of protein localization in organelle
intersection_of: GO:0045185 ! maintenance of protein location
intersection_of: occurs_in GO:0005816 ! spindle pole body
relationship: occurs_in GO:0005816 ! spindle pole body
relationship: part_of GO:0051300 ! spindle pole body organization
relationship: part_of GO:0071988 ! protein localization to spindle pole body
created_by: midori
creation_date: 2010-10-25T11:02:31Z

[Term]
id: GO:0071991
name: phytochelatin transporter activity
namespace: molecular_function
def: "Enables the directed movement of a phytochelatin into, out of or within a cell, or between cells. Phytochelatins are a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes." [GOC:mah, ISBN:0198506732]
synonym: "cadystin transporter activity" RELATED [GOC:vw, http://en.wikipedia.org/wiki/Phytochelatin#History]
is_a: GO:0015197 ! peptide transporter activity
relationship: part_of GO:0071993 ! phytochelatin transport
created_by: midori
creation_date: 2010-10-25T01:00:17Z

[Term]
id: GO:0071992
name: phytochelatin transmembrane transporter activity
namespace: molecular_function
def: "Enables the directed movement of a phytochelatin across a membrane into, out of or within a cell, or between cells. Phytochelatins are a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes." [GOC:mah, ISBN:0198506732]
synonym: "cadystin transmembrane transporter activity" RELATED [GOC:vw, http://en.wikipedia.org/wiki/Phytochelatin#History]
is_a: GO:0071991 ! phytochelatin transporter activity
is_a: GO:1904680 ! peptide transmembrane transporter activity
relationship: part_of GO:0071994 ! phytochelatin transmembrane transport
created_by: midori
creation_date: 2010-10-25T01:02:27Z

[Term]
id: GO:0071993
name: phytochelatin transport
namespace: biological_process
def: "The directed movement of a phytochelatin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phytochelatins are a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes." [GOC:mah, ISBN:0198506732]
synonym: "cadystin transport" RELATED [GOC:vw, http://en.wikipedia.org/wiki/Phytochelatin#History]
is_a: GO:0015833 ! peptide transport
created_by: midori
creation_date: 2010-10-25T01:57:55Z

[Term]
id: GO:0071994
name: phytochelatin transmembrane transport
namespace: biological_process
def: "The directed movement of a phytochelatin across a membrane into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phytochelatins are a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes." [GOC:mah, ISBN:0198506732]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "cadystin transmembrane transport" RELATED [GOC:vw, http://en.wikipedia.org/wiki/Phytochelatin#History]
synonym: "phytochelatin membrane transport" EXACT []
is_a: GO:0055085 ! transmembrane transport
is_a: GO:0071993 ! phytochelatin transport
created_by: midori
creation_date: 2010-10-25T01:58:50Z

[Term]
id: GO:0071995
name: phytochelatin import into vacuole
namespace: biological_process
def: "The directed movement of phytochelatins into the vacuole. Phytochelatins are a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes." [GOC:mah, ISBN:0198506732]
synonym: "cadystin import into vacuole" RELATED [GOC:vw, http://en.wikipedia.org/wiki/Phytochelatin#History]
synonym: "phytochelatin transport into vacuole" EXACT [GOC:vw]
is_a: GO:0034486 ! vacuolar transmembrane transport
is_a: GO:0071994 ! phytochelatin transmembrane transport
created_by: midori
creation_date: 2010-10-25T02:01:59Z

[Term]
id: GO:0071996
name: glutathione transmembrane import into vacuole
namespace: biological_process
def: "The directed movement of glutathione into the vacuole across the vacuolar membrane." [GOC:mah]
synonym: "glutathione transport into vacuole" EXACT [GOC:vw]
is_a: GO:0034486 ! vacuolar transmembrane transport
is_a: GO:0034775 ! glutathione transmembrane transport
created_by: midori
creation_date: 2010-10-25T02:12:01Z

[Term]
id: GO:0071997
name: glutathione S-conjugate-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of glutathione S-conjugate across a membrane." [GOC:mah]
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances
created_by: midori
creation_date: 2010-10-25T02:32:02Z

[Term]
id: GO:0071998
name: ascospore release from ascus
namespace: biological_process
def: "A developmental process that results in the discharge of ascospores from the ascus. Ascospore release may be active or passive." [DOI:10.1016/S0953-7562(96)80057-8, GOC:mah]
synonym: "ascospore liberation" EXACT [DOI:10.1016/S0953-7562(96)80057-8]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048869 ! cellular developmental process
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0043935 ! sexual sporulation resulting in formation of a cellular spore
created_by: midori
creation_date: 2010-10-25T03:41:44Z

[Term]
id: GO:0071999
name: extracellular polysaccharide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of polysaccharides used in extracellular structures." [GOC:mah, GOC:vw]
subset: gosubset_prok
synonym: "extracellular polysaccharide breakdown" EXACT [GOC:mah]
synonym: "extracellular polysaccharide catabolism" EXACT [GOC:mah]
synonym: "extracellular polysaccharide degradation" EXACT [GOC:mah]
is_a: GO:0044247 ! cellular polysaccharide catabolic process
is_a: GO:0046379 ! extracellular polysaccharide metabolic process
created_by: midori
creation_date: 2010-10-25T05:11:25Z

[Term]
id: GO:0072000
name: extracellular polysaccharide catabolic process involved in ascospore release from ascus
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of polysaccharides in the ascus wall that contributes to the release of ascospores from the ascus." [GOC:mah, GOC:vw]
subset: gosubset_prok
synonym: "ascus catabolic process" RELATED [GOC:vw]
synonym: "ascus endolysis" RELATED [GOC:vw]
synonym: "extracellular polysaccharide breakdown involved in ascospore release from ascus" EXACT [GOC:mah]
synonym: "extracellular polysaccharide catabolism involved in ascospore release from ascus" EXACT [GOC:mah]
synonym: "extracellular polysaccharide degradation involved in ascospore release from ascus" EXACT [GOC:mah]
is_a: GO:0044724 ! single-organism carbohydrate catabolic process
is_a: GO:0071999 ! extracellular polysaccharide catabolic process
is_a: GO:1903046 ! meiotic cell cycle process
intersection_of: GO:0071999 ! extracellular polysaccharide catabolic process
intersection_of: part_of GO:0071998 ! ascospore release from ascus
relationship: part_of GO:0071998 ! ascospore release from ascus
created_by: midori
creation_date: 2010-10-25T05:30:41Z

[Term]
id: GO:0072001
name: renal system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the renal system over time, from its formation to the mature structure. The renal system maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels." [GOC:mtg_kidney_jan10, GOC:yaf, http://en.wikibooks.org/wiki/Human_Physiology/The_Urinary_System]
synonym: "urinary system development" BROAD [GOC:yaf]
synonym: "urinary tract development" BROAD [GOC:yaf, PMID:17881463]
is_a: GO:0048731 ! system development
relationship: part_of GO:0001655 ! urogenital system development
created_by: midori
creation_date: 2010-01-25T10:31:00Z

[Term]
id: GO:0072002
name: Malpighian tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the Malpighian tubule over time, from its formation to the mature structure. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut." [FBbt:00005786, GOC:mtg_kidney_jan10, PMID:19783135]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048513 ! animal organ development
is_a: GO:0061326 ! renal tubule development
created_by: midori
creation_date: 2010-01-25T10:54:30Z

[Term]
id: GO:0072003
name: kidney rudiment formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a kidney rudiment from unspecified parts. A kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:mtg_kidney_jan10]
synonym: "kidney anlage formation" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0060993 ! kidney morphogenesis
created_by: midori
creation_date: 2010-01-25T11:18:58Z

[Term]
id: GO:0072004
name: kidney field specification
namespace: biological_process
def: "The process that results in the delineation of regions of the embryo into the area in which the kidney rudiment will develop." [GOC:mtg_kidney_jan10]
synonym: "specification of kidney anlage" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0010092 ! specification of organ identity
is_a: GO:0061004 ! pattern specification involved in kidney development
relationship: part_of GO:0072003 ! kidney rudiment formation
created_by: midori
creation_date: 2010-01-25T11:24:33Z

[Term]
id: GO:0072005
name: maintenance of kidney identity
namespace: biological_process
def: "The process in which the identity of a kidney is maintained. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:mtg_kidney_jan10]
synonym: "maintenance of kidney anlage identity" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0048496 ! maintenance of organ identity
relationship: part_of GO:0072003 ! kidney rudiment formation
created_by: midori
creation_date: 2010-01-25T11:57:41Z

[Term]
id: GO:0072006
name: nephron development
namespace: biological_process
def: "The process whose specific outcome is the progression of the nephron over time, from its formation to the mature structure. A nephron is the functional unit of the kidney." [GOC:mtg_kidney_jan10]
synonym: "nephrogenesis" RELATED [GOC:rph]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0001822 ! kidney development
created_by: midori
creation_date: 2010-01-25T01:37:16Z

[Term]
id: GO:0072007
name: mesangial cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesangial cells of the kidney as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
is_a: GO:0061005 ! cell differentiation involved in kidney development
is_a: GO:1904238 ! pericyte cell differentiation
created_by: midori
creation_date: 2010-01-25T01:59:09Z

[Term]
id: GO:0072008
name: glomerular mesangial cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the glomerular mesangial cells of the kidney as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
is_a: GO:0035850 ! epithelial cell differentiation involved in kidney development
is_a: GO:0072007 ! mesangial cell differentiation
is_a: GO:0072071 ! kidney interstitial fibroblast differentiation
relationship: part_of GO:0072109 ! glomerular mesangium development
created_by: midori
creation_date: 2010-01-25T01:59:33Z

[Term]
id: GO:0072009
name: nephron epithelium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the nephron epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The nephron epithelium is a tissue that covers the surface of a nephron." [GOC:mtg_kidney_jan10]
is_a: GO:0072073 ! kidney epithelium development
relationship: part_of GO:0072006 ! nephron development
created_by: midori
creation_date: 2010-01-25T02:01:39Z

[Term]
id: GO:0072010
name: glomerular epithelium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the glomerular epithelium over time, from its formation to the mature structure. The glomerular epithelium is an epithelial tissue that covers the outer surfaces of the glomerulus. The glomerular epithelium consists of both parietal and visceral epithelium. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072009 ! nephron epithelium development
relationship: part_of GO:0032835 ! glomerulus development
created_by: midori
creation_date: 2010-01-25T02:02:14Z

[Term]
id: GO:0072011
name: glomerular endothelium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the glomerular endothelium over time, from its formation to the mature structure. The glomerular endothelium is an epithelial tissue that covers the internal surfaces of the glomerulus." [GOC:mtg_kidney_jan10]
is_a: GO:0003158 ! endothelium development
is_a: GO:0072010 ! glomerular epithelium development
relationship: part_of GO:0072012 ! glomerulus vasculature development
created_by: midori
creation_date: 2010-01-25T02:02:57Z

[Term]
id: GO:0072012
name: glomerulus vasculature development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a glomerulus vasculature from an initial condition to its mature state. This process begins with the formation of the glomerulus vasculature and ends with the mature structure. The glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the glomerulus." [GOC:mtg_kidney_jan10]
synonym: "glomerulus capillary development" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0001568 ! blood vessel development
is_a: GO:0061440 ! kidney vasculature development
relationship: part_of GO:0032835 ! glomerulus development
created_by: midori
creation_date: 2010-01-25T02:05:04Z

[Term]
id: GO:0072013
name: glomus development
namespace: biological_process
def: "The progression of the glomus over time from its initial formation until its mature state. The glomus forms from the splanchnic intermediate mesoderm and is the vascularized filtration unit, filtering the blood before it enters the tubules. The glomus is external to the nephron and extends over more than one body segment." [GOC:mtg_kidney_jan10, PMID:10572058, PMID:15647339, PMID:9268568, XAO:0000318]
synonym: "pronephric glomus development" EXACT [GOC:mtg_kidney_jan10, PMID:15895368]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048793 ! pronephros development
created_by: midori
creation_date: 2010-01-25T02:23:19Z

[Term]
id: GO:0072014
name: proximal tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the proximal tubule over time, from its formation to the mature structure. In mammals, the proximal tubule is a nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle. It has a brush border epithelial morphology." [GOC:mtg_kidney_jan10]
is_a: GO:0072080 ! nephron tubule development
created_by: midori
creation_date: 2010-01-25T02:33:46Z

[Term]
id: GO:0072015
name: glomerular visceral epithelial cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a glomerular visceral epithelial cell over time, from its formation to the mature structure. A glomerular visceral epithelial cell is a specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells." [GOC:mtg_kidney_jan10]
synonym: "podocyte development" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0072310 ! glomerular epithelial cell development
relationship: part_of GO:0072112 ! glomerular visceral epithelial cell differentiation
created_by: midori
creation_date: 2010-01-25T02:12:45Z

[Term]
id: GO:0072016
name: glomerular parietal epithelial cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a glomerular parietal epithelial cell over time, from its formation to the mature structure. Glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport." [GOC:mtg_kidney_jan10]
synonym: "Bowman's capsule development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072310 ! glomerular epithelial cell development
relationship: part_of GO:0072139 ! glomerular parietal epithelial cell differentiation
created_by: midori
creation_date: 2010-01-25T02:13:16Z

[Term]
id: GO:0072017
name: distal tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the distal tubule over time, from its formation to the mature structure. In mammals, the distal tubule is a nephron tubule that begins at the macula densa and extends to the connecting tubule." [GOC:mtg_kidney_jan10]
is_a: GO:0072080 ! nephron tubule development
created_by: midori
creation_date: 2010-01-25T02:34:19Z

[Term]
id: GO:0072019
name: proximal convoluted tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the proximal convoluted tubule over time, from its formation to the mature structure. The proximal convoluted tubule is the most proximal portion of the proximal tubule and extends from the glomerular capsule to the proximal straight tubule." [GOC:mtg_kidney_jan10]
is_a: GO:0072080 ! nephron tubule development
relationship: part_of GO:0072014 ! proximal tubule development
created_by: midori
creation_date: 2010-01-25T02:35:35Z

[Term]
id: GO:0072020
name: proximal straight tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the proximal straight tubule over time, from its formation to the mature structure. The proximal straight tubule is the part of the descending limb that extends from the proximal convoluted tubule to the descending thin tubule." [GOC:mtg_kidney_jan10]
synonym: "S3 development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072080 ! nephron tubule development
relationship: part_of GO:0072014 ! proximal tubule development
created_by: midori
creation_date: 2010-01-25T02:36:14Z

[Term]
id: GO:0072021
name: ascending thin limb development
namespace: biological_process
def: "The process whose specific outcome is the progression of an ascending thin limb over time, from its formation to the mature structure. The ascending thin limb is a segment of a nephron tubule lying in the inner medulla that is permeable to ions but not to water and has a simple epithelium; active transepithelial solute transport is absent." [GOC:mtg_kidney_jan10]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0072080 ! nephron tubule development
relationship: part_of GO:0072070 ! loop of Henle development
created_by: midori
creation_date: 2010-01-25T02:37:13Z

[Term]
id: GO:0072022
name: descending thin limb development
namespace: biological_process
def: "The process whose specific outcome is the progression of the descending thin limb over time, from its formation to the mature structure. The descending thin limb is a part of the loop of Henle situated just after the proximal straight tubule (S3). It extends to the tip of the loop of Henle." [GOC:mtg_kidney_jan10]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0072070 ! loop of Henle development
created_by: midori
creation_date: 2010-01-25T02:37:47Z

[Term]
id: GO:0072023
name: thick ascending limb development
namespace: biological_process
alt_id: GO:0072026
def: "The process whose specific outcome is the progression of the thick ascending limb over time, from its formation to the mature structure. The thick ascending limb is the last part of the loop of Henle. Its thick, mitochondria-rich epithelium characterizes the outer medulla, and is responsible for very avid active salt transport. At the macula densa, the thick ascending limb connects to the distal convoluted tubule." [GOC:mtg_kidney_jan10]
synonym: "TAL development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072080 ! nephron tubule development
relationship: part_of GO:0072017 ! distal tubule development
created_by: midori
creation_date: 2010-01-25T02:39:51Z

[Term]
id: GO:0072024
name: macula densa development
namespace: biological_process
def: "The process whose specific outcome is the progression of the macula densa over time, from its formation to the mature structure. The macula densa is an area of specialized cells in the distal tubule that makes contact with the vascular pole of the glomerulus." [GOC:mtg_kidney_jan10]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0072009 ! nephron epithelium development
relationship: part_of GO:0072006 ! nephron development
relationship: part_of GO:0072051 ! juxtaglomerular apparatus development
created_by: midori
creation_date: 2010-01-25T02:40:15Z

[Term]
id: GO:0072025
name: distal convoluted tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the distal convoluted tubule over time, from its formation to the mature structure. The distal convoluted tubule is the first segment of the nephron lying just downstream from the loop of Henle, immediately after the macula densa. Among other functions, in humans it is responsible for the reabsorption of about 5% of filtered sodium via the thiazide-sensitive Na-Cl symporter." [GOC:mtg_kidney_jan10]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0072080 ! nephron tubule development
relationship: part_of GO:0072017 ! distal tubule development
created_by: midori
creation_date: 2010-01-25T02:40:45Z

[Term]
id: GO:0072027
name: connecting tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the connecting tubule over time, from its formation to the mature structure. The connecting tubule is a tubular segment of the nephron; it connects the distal convoluted tubule to the collecting duct." [GOC:mtg_kidney_jan10]
synonym: "connecting duct development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072080 ! nephron tubule development
created_by: midori
creation_date: 2010-01-25T02:42:05Z

[Term]
id: GO:0072028
name: nephron morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the nephron are generated and organized. A nephron is the functional unit of the kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0060993 ! kidney morphogenesis
relationship: part_of GO:0072006 ! nephron development
created_by: midori
creation_date: 2010-01-25T02:45:52Z

[Term]
id: GO:0072029
name: long nephron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a long nephron over time, from its formation to the mature structure. Long nephrons are associated with juxtamedullary glomeruli and extend into the inner medulla." [GOC:mtg_kidney_jan10]
synonym: "juxtamedullary nephron development" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0072006 ! nephron development
created_by: midori
creation_date: 2010-01-25T02:49:08Z

[Term]
id: GO:0072030
name: short nephron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a short nephron over time, from its formation to the mature structure. Short nephrons are associated with mid-cortical and superficial glomeruli, are situated entirely in the outer medulla, and have no thin ascending limb." [GOC:mtg_kidney_jan10]
is_a: GO:0072006 ! nephron development
created_by: midori
creation_date: 2010-01-25T02:49:32Z

[Term]
id: GO:0072031
name: proximal convoluted tubule segment 1 development
namespace: biological_process
def: "The process whose specific outcome is the progression of the S1 portion of the proximal convoluted tubule over time, from its formation to the mature structure. The S1 portion is the initial portion of the proximal convoluted tubule and is responsible for avid reabsorption of water and solutes." [GOC:mtg_kidney_jan10, MA:0002612]
synonym: "S1 development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0035295 ! tube development
relationship: part_of GO:0072019 ! proximal convoluted tubule development
created_by: midori
creation_date: 2010-01-25T02:55:57Z

[Term]
id: GO:0072032
name: proximal convoluted tubule segment 2 development
namespace: biological_process
def: "The process whose specific outcome is the progression of the S2 portion of the proximal convoluted tubule over time, from its formation to the mature structure. The S2 portion of the tubule is involved in reabsorption of water and sodium chloride." [GOC:mtg_kidney_jan10, MA:0002613]
synonym: "S2 development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0035295 ! tube development
relationship: part_of GO:0072019 ! proximal convoluted tubule development
created_by: midori
creation_date: 2010-01-25T02:56:36Z

[Term]
id: GO:0072033
name: renal vesicle formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the renal vesicle from condensed mesenchymal cells. The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells." [GOC:mtg_kidney_jan10]
synonym: "nephron epithelium formation" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0072077 ! renal vesicle morphogenesis
created_by: midori
creation_date: 2010-01-25T02:57:03Z

[Term]
id: GO:0072034
name: renal vesicle induction
namespace: biological_process
def: "Signaling at short range between cells of the ureteric bud terminus and the kidney mesenchyme that positively regulates the formation of the renal vesicle." [GOC:mtg_kidney_jan10]
synonym: "nephron induction" EXACT [GOC:mtg_kidney_jan10]
synonym: "positive regulation of nephron formation" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0031128 ! developmental induction
is_a: GO:0090184 ! positive regulation of kidney development
is_a: GO:2000027 ! regulation of organ morphogenesis
relationship: positively_regulates GO:0072033 ! renal vesicle formation
created_by: midori
creation_date: 2010-01-25T02:58:18Z

[Term]
id: GO:0072035
name: pre-tubular aggregate formation
namespace: biological_process
def: "The cell adhesion process in which mesenchyme cells adhere to one another in the initial stages of the formation of the pre-tubular aggregate, the earliest recognizable structure of the kidney." [GOC:mtg_kidney_jan10]
synonym: "mesenchymal cell condensation involved in renal vesicle formation" EXACT [GOC:mtg_kidney_jan10]
synonym: "nephron epithelium formation" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0016337 ! single organismal cell-cell adhesion
relationship: part_of GO:0072033 ! renal vesicle formation
created_by: midori
creation_date: 2010-01-25T03:03:10Z

[Term]
id: GO:0072036
name: mesenchymal to epithelial transition involved in renal vesicle formation
namespace: biological_process
def: "A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the renal vesicle." [GOC:mtg_kidney_jan10]
is_a: GO:0060231 ! mesenchymal to epithelial transition
intersection_of: GO:0060231 ! mesenchymal to epithelial transition
intersection_of: part_of GO:0072033 ! renal vesicle formation
relationship: part_of GO:0072033 ! renal vesicle formation
created_by: midori
creation_date: 2010-01-25T03:04:24Z

[Term]
id: GO:0072037
name: mesenchymal stem cell differentiation involved in nephron morphogenesis
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal stem cell that contributes to the shaping of a nephron. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [GOC:mtg_kidney_jan10]
is_a: GO:0061005 ! cell differentiation involved in kidney development
is_a: GO:0072497 ! mesenchymal stem cell differentiation
intersection_of: GO:0072497 ! mesenchymal stem cell differentiation
intersection_of: part_of GO:0072028 ! nephron morphogenesis
relationship: part_of GO:0072028 ! nephron morphogenesis
created_by: midori
creation_date: 2010-01-25T03:07:39Z

[Term]
id: GO:0072038
name: mesenchymal stem cell maintenance involved in nephron morphogenesis
namespace: biological_process
def: "The process in which an organism retains a population of mesenchymal stem cells that contributes to the shaping of a nephron. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [GOC:mtg_kidney_jan10]
is_a: GO:0035019 ! somatic stem cell population maintenance
relationship: part_of GO:0072028 ! nephron morphogenesis
created_by: midori
creation_date: 2010-01-25T03:08:05Z

[Term]
id: GO:0072039
name: regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis
namespace: biological_process
def: "Any process that modulates the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10]
synonym: "regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis" NARROW []
synonym: "regulation of mesenchymal stem cell apoptotic process involved in nephron morphogenesis" EXACT []
is_a: GO:0090183 ! regulation of kidney development
is_a: GO:1902337 ! regulation of apoptotic process involved in morphogenesis
is_a: GO:1904672 ! regulation of somatic stem cell population maintenance
is_a: GO:2000027 ! regulation of organ morphogenesis
is_a: GO:2001053 ! regulation of mesenchymal cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1901145 ! mesenchymal cell apoptotic process involved in nephron morphogenesis
relationship: regulates GO:0072038 ! mesenchymal stem cell maintenance involved in nephron morphogenesis
relationship: regulates GO:1901145 ! mesenchymal cell apoptotic process involved in nephron morphogenesis
created_by: midori
creation_date: 2010-01-25T03:08:34Z

[Term]
id: GO:0072040
name: negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis
namespace: biological_process
def: "Any process that reduces the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10]
synonym: "negative regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis" NARROW []
synonym: "negative regulation of mesenchymal stem cell apoptotic process involved in nephron morphogenesis" EXACT []
is_a: GO:0072039 ! regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis
is_a: GO:0090185 ! negative regulation of kidney development
is_a: GO:1902338 ! negative regulation of apoptotic process involved in morphogenesis
is_a: GO:1904673 ! negative regulation of somatic stem cell population maintenance
is_a: GO:2001054 ! negative regulation of mesenchymal cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1901145 ! mesenchymal cell apoptotic process involved in nephron morphogenesis
relationship: negatively_regulates GO:0072038 ! mesenchymal stem cell maintenance involved in nephron morphogenesis
relationship: negatively_regulates GO:1901145 ! mesenchymal cell apoptotic process involved in nephron morphogenesis
created_by: midori
creation_date: 2010-01-25T03:09:30Z

[Term]
id: GO:0072041
name: positive regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis
namespace: biological_process
def: "Any process that increases the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10]
synonym: "positive regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis" NARROW []
synonym: "positive regulation of mesenchymal stem cell apoptotic process involved in nephron morphogenesis" EXACT []
is_a: GO:0072039 ! regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis
is_a: GO:0090184 ! positive regulation of kidney development
is_a: GO:1902339 ! positive regulation of apoptotic process involved in morphogenesis
is_a: GO:1904674 ! positive regulation of somatic stem cell population maintenance
is_a: GO:2001055 ! positive regulation of mesenchymal cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1901145 ! mesenchymal cell apoptotic process involved in nephron morphogenesis
relationship: positively_regulates GO:0072038 ! mesenchymal stem cell maintenance involved in nephron morphogenesis
relationship: positively_regulates GO:1901145 ! mesenchymal cell apoptotic process involved in nephron morphogenesis
created_by: midori
creation_date: 2010-01-25T03:10:32Z

[Term]
id: GO:0072042
name: regulation of mesenchymal stem cell proliferation involved in nephron morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesenchymal stem cell proliferation and contributes to the shaping of a nephron." [GOC:mtg_kidney_jan10]
is_a: GO:1902460 ! regulation of mesenchymal stem cell proliferation
relationship: regulates GO:0072090 ! mesenchymal stem cell proliferation involved in nephron morphogenesis
created_by: midori
creation_date: 2010-01-25T03:11:26Z

[Term]
id: GO:0072043
name: regulation of pre-tubular aggregate formation by cell-cell signaling
namespace: biological_process
def: "Any process that mediates the transfer of information from one cell to another that modulates the rate, frequency, or extent of pre-tubular aggregate formation. Pre-tubular aggregate formation is the cell adhesion process in which mesenchymal cells adhere to one another in the initial stages of the formation of the pre-tubular aggregate, the earliest recognizable structure of the kidney." [GOC:mtg_kidney_jan10]
synonym: "regulation of pre-tubular aggregate formation by cell-cell signalling" EXACT [GOC:mah]
is_a: GO:0007267 ! cell-cell signaling
is_a: GO:0022407 ! regulation of cell-cell adhesion
is_a: GO:0090183 ! regulation of kidney development
is_a: GO:2000027 ! regulation of organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072035 ! pre-tubular aggregate formation
relationship: regulates GO:0072035 ! pre-tubular aggregate formation
created_by: midori
creation_date: 2010-01-25T03:12:03Z

[Term]
id: GO:0072044
name: collecting duct development
namespace: biological_process
def: "The process whose specific outcome is the progression of a collecting duct over time, from its formation to the mature structure. The collecting duct responds to vasopressin and aldosterone to regulate water, electrolyte and acid-base balance. It is the final common path through which urine flows before entering the ureter and then emptying into the bladder." [GOC:mtg_kidney_jan10]
is_a: GO:0035295 ! tube development
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0001822 ! kidney development
created_by: midori
creation_date: 2010-01-25T03:18:06Z

[Term]
id: GO:0072045
name: convergent extension involved in nephron morphogenesis
namespace: biological_process
def: "The morphogenetic process in which the renal epithelium narrows along one axis and lengthens in a perpendicular axis that contributes to the shaping of a nephron." [GOC:mtg_kidney_jan10]
is_a: GO:0060029 ! convergent extension involved in organogenesis
intersection_of: GO:0060026 ! convergent extension
intersection_of: part_of GO:0072028 ! nephron morphogenesis
relationship: part_of GO:0072028 ! nephron morphogenesis
created_by: midori
creation_date: 2010-01-25T03:22:47Z

[Term]
id: GO:0072046
name: establishment of planar polarity involved in nephron morphogenesis
namespace: biological_process
def: "Coordinated organization of groups of cells in the plane of an epithelium that contributes to the shaping of a nephron." [GOC:mtg_kidney_jan10]
synonym: "establishment of planar cell polarity involved in nephron morphogenesis" NARROW [GOC:mtg_kidney_jan10]
is_a: GO:0001736 ! establishment of planar polarity
intersection_of: GO:0001736 ! establishment of planar polarity
intersection_of: part_of GO:0072028 ! nephron morphogenesis
relationship: part_of GO:0072028 ! nephron morphogenesis
created_by: midori
creation_date: 2010-01-25T03:24:04Z

[Term]
id: GO:0072047
name: proximal/distal pattern formation involved in nephron development
namespace: biological_process
def: "The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis of a nephron. The proximal/distal axis is defined by a line that runs from the center of the kidney (proximal end) outward (distal end)." [GOC:mtg_kidney_jan10]
synonym: "proximal-distal pattern formation involved in nephron development" EXACT [GOC:mtg_kidney_jan10]
synonym: "proximal/distal nephron patterning" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0009954 ! proximal/distal pattern formation
is_a: GO:0061004 ! pattern specification involved in kidney development
intersection_of: GO:0009954 ! proximal/distal pattern formation
intersection_of: part_of GO:0072006 ! nephron development
relationship: part_of GO:0072006 ! nephron development
created_by: midori
creation_date: 2010-01-25T03:30:48Z

[Term]
id: GO:0072048
name: renal system pattern specification
namespace: biological_process
def: "Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate into the anatomical structures of the renal system." [GOC:mtg_kidney_jan10]
synonym: "renal system pattern formation" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0007389 ! pattern specification process
relationship: part_of GO:0072001 ! renal system development
created_by: midori
creation_date: 2010-01-25T03:31:51Z

[Term]
id: GO:0072049
name: comma-shaped body morphogenesis
namespace: biological_process
def: "The process in which the comma-shaped body is generated and organized. The comma-shaped body is the precursor structure to the S-shaped body that contributes to the morphogenesis of the nephron." [GOC:mtg_kidney_jan10]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0072028 ! nephron morphogenesis
created_by: midori
creation_date: 2010-01-25T03:44:48Z

[Term]
id: GO:0072050
name: S-shaped body morphogenesis
namespace: biological_process
def: "The process in which the S-shaped body is generated and organized. The S-shaped body is the successor of the comma-shaped body that contributes to the morphogenesis of the nephron." [GOC:mtg_kidney_jan10]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0072028 ! nephron morphogenesis
created_by: midori
creation_date: 2010-01-25T03:45:19Z

[Term]
id: GO:0072051
name: juxtaglomerular apparatus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the juxtaglomerular apparatus over time, from its formation to the mature structure. The juxtaglomerular apparatus is an anatomical structure that lies adjacent to the glomerulus and regulates kidney function." [GOC:mtg_kidney_jan10]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0001822 ! kidney development
created_by: midori
creation_date: 2010-01-25T03:52:23Z

[Term]
id: GO:0072052
name: juxtaglomerulus cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the juxtaglomerulus cells of the kidney as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
is_a: GO:0061005 ! cell differentiation involved in kidney development
relationship: part_of GO:0072051 ! juxtaglomerular apparatus development
created_by: midori
creation_date: 2010-01-25T03:58:01Z

[Term]
id: GO:0072053
name: renal inner medulla development
namespace: biological_process
def: "The process whose specific outcome is the progression of the renal inner medulla over time, from its formation to the mature structure. The renal inner medulla is unique to mammalian kidneys and is the innermost region of the mammalian kidney." [GOC:mtg_kidney_jan10]
synonym: "inner renal medulla development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0001822 ! kidney development
created_by: midori
creation_date: 2010-01-25T03:59:37Z

[Term]
id: GO:0072054
name: renal outer medulla development
namespace: biological_process
def: "The process whose specific outcome is the progression of the renal outer medulla over time, from its formation to the mature structure. The renal outer medulla is the region of the kidney that lies between the renal cortex and the renal inner medulla." [GOC:mtg_kidney_jan10]
synonym: "outer renal medulla development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0001822 ! kidney development
created_by: midori
creation_date: 2010-01-25T04:00:42Z

[Term]
id: GO:0072055
name: renal cortex development
namespace: biological_process
def: "The process whose specific outcome is the progression of the renal cortex over time, from its formation to the mature structure. The renal cortex is the outer region of the kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0001822 ! kidney development
created_by: midori
creation_date: 2010-01-25T04:01:12Z

[Term]
id: GO:0072056
name: pyramid development
namespace: biological_process
def: "The process whose specific outcome is the progression of the kidney pyramids over time, from its formation to the mature structure. Kidney pyramids are the conical masses that constitute the renal medulla in a multi-lobed mammalian kidney; they contain the loops of Henle and the medullary collecting ducts." [GOC:mtg_kidney_jan10]
synonym: "kidney pyramid development" EXACT [GOC:mah]
synonym: "pyramids development" EXACT [GOC:mah]
synonym: "renal medulla development" EXACT [GOC:mah]
synonym: "renal pyramid development" EXACT [GOC:mah]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0001822 ! kidney development
created_by: midori
creation_date: 2010-01-25T04:01:36Z

[Term]
id: GO:0072057
name: inner stripe development
namespace: biological_process
def: "The process whose specific outcome is the progression of the inner stripe over time, from its formation to the mature structure. The inner stripe is a deep, centrally located portion of the renal outer medulla and is traversed by thin descending and thick ascending portions of the loops of Henle." [GOC:mtg_kidney_jan10]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0072054 ! renal outer medulla development
created_by: midori
creation_date: 2010-01-25T04:01:58Z

[Term]
id: GO:0072058
name: outer stripe development
namespace: biological_process
def: "The process whose specific outcome is the progression of the outer stripe over time, from its formation to the mature structure. The outer stripe is the region of the kidney outer medulla that lies just below the cortex. The proximal straight tubules (S3) characterize this region." [GOC:mtg_kidney_jan10]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0072054 ! renal outer medulla development
created_by: midori
creation_date: 2010-01-25T04:02:56Z

[Term]
id: GO:0072059
name: cortical collecting duct development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cortical collecting duct over time, from its formation to the mature structure. The cortical collecting duct is the portion of the collecting duct that resides in the renal cortex." [GOC:mtg_kidney_jan10]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
created_by: midori
creation_date: 2010-01-25T04:07:07Z

[Term]
id: GO:0072060
name: outer medullary collecting duct development
namespace: biological_process
def: "The process whose specific outcome is the progression of the outer medullary collecting duct over time, from its formation to the mature structure. The outer medullary collecting duct is the portion of the collecting duct that lies in the renal outer medulla." [GOC:mtg_kidney_jan10]
is_a: GO:0072044 ! collecting duct development
created_by: midori
creation_date: 2010-01-25T04:08:18Z

[Term]
id: GO:0072061
name: inner medullary collecting duct development
namespace: biological_process
def: "The process whose specific outcome is the progression of the inner medullary collecting duct over time, from its formation to the mature structure. The inner medullary collecting duct is the portion of the collecting duct that lies in the renal inner medulla." [GOC:mtg_kidney_jan10]
is_a: GO:0072044 ! collecting duct development
created_by: midori
creation_date: 2010-01-25T04:08:45Z

[Term]
id: GO:0072062
name: proximal convoluted tubule segment 1 cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the S1 cells of the kidney as it progresses from its formation to the mature state." [GOC:bf, GOC:mtg_kidney_jan10]
synonym: "S1 cell differentiation" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0061005 ! cell differentiation involved in kidney development
relationship: part_of GO:0072031 ! proximal convoluted tubule segment 1 development
created_by: midori
creation_date: 2010-01-25T04:11:17Z

[Term]
id: GO:0072063
name: short descending thin limb development
namespace: biological_process
def: "The process whose specific outcome is the progression of the short descending thin limb over time, from its formation to the mature structure. The short descending thin limb is the descending thin limb of a short nephron that has a squamous epithelial morphology." [GOC:mtg_kidney_jan10]
is_a: GO:0072009 ! nephron epithelium development
is_a: GO:0072022 ! descending thin limb development
relationship: part_of GO:0072030 ! short nephron development
created_by: midori
creation_date: 2010-01-25T04:12:39Z

[Term]
id: GO:0072064
name: long descending thin limb development
namespace: biological_process
def: "The process whose specific outcome is the progression of the long descending thin limb over time, from its formation to the mature structure. The long descending thin limb is the descending thin limb of a long nephron that has a squamous epithelial morphology. The long descending limb starts in the inner stripe of the outer medulla and extends into the inner medulla." [GOC:mtg_kidney_jan10]
is_a: GO:0072009 ! nephron epithelium development
is_a: GO:0072022 ! descending thin limb development
relationship: part_of GO:0072029 ! long nephron development
created_by: midori
creation_date: 2010-01-25T04:13:17Z

[Term]
id: GO:0072065
name: long descending thin limb bend development
namespace: biological_process
def: "The process whose specific outcome is the progression of the long descending thin limb bend over time, from its formation to the mature structure. The long descending thin limb bend is a part of the descending thin limb of a long nephron that lies beyond the prebend segment." [GOC:mtg_kidney_jan10]
is_a: GO:0035295 ! tube development
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0072064 ! long descending thin limb development
created_by: midori
creation_date: 2010-01-25T04:13:38Z

[Term]
id: GO:0072066
name: prebend segment development
namespace: biological_process
def: "The process whose specific outcome is the progression of the prebend segment over time, from its formation to the mature structure. The prebend segment is a part of the descending thin limb that lies before the bend and exhibits permeabilities characteristic of the ascending limb, especially negligible water permeability." [GOC:mtg_kidney_jan10]
is_a: GO:0035295 ! tube development
relationship: part_of GO:0072022 ! descending thin limb development
created_by: midori
creation_date: 2010-01-25T04:14:02Z

[Term]
id: GO:0072067
name: early distal convoluted tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the early distal convoluted tubule over time, from its formation to the mature structure. The early distal convoluted tubule contains DCT cells and is vasopressin-insensitive." [GOC:mtg_kidney_jan10]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0072009 ! nephron epithelium development
relationship: part_of GO:0072025 ! distal convoluted tubule development
created_by: midori
creation_date: 2010-01-25T04:15:17Z

[Term]
id: GO:0072068
name: late distal convoluted tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the late distal convoluted tubule over time, from its formation to the mature structure. The late distal convoluted tubule contains DCT cells and intercalated (IC) alpha and beta cells and is vasopressin-sensitive." [GOC:mtg_kidney_jan10]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0072009 ! nephron epithelium development
relationship: part_of GO:0072025 ! distal convoluted tubule development
created_by: midori
creation_date: 2010-01-25T04:15:50Z

[Term]
id: GO:0072069
name: DCT cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the distal convoluted tubule cells of the kidney as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
synonym: "distal convoluted tubule cell differentiation" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0061005 ! cell differentiation involved in kidney development
relationship: part_of GO:0072025 ! distal convoluted tubule development
created_by: midori
creation_date: 2010-01-25T04:17:22Z

[Term]
id: GO:0072070
name: loop of Henle development
namespace: biological_process
alt_id: GO:0072018
def: "The process whose specific outcome is the progression of the loop of Henle over time, from its formation to the mature structure. The loop of Henle is a nephron tubule that connects the proximal convoluted tubule to the distal convoluted tubule." [GOC:mtg_kidney_jan10]
synonym: "intermediate tubule development" EXACT []
is_a: GO:0072080 ! nephron tubule development
created_by: midori
creation_date: 2010-01-25T04:20:27Z

[Term]
id: GO:0072071
name: kidney interstitial fibroblast differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the interstitial fibroblast of the kidney as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
synonym: "kidney interstitial cell differentiation" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0061005 ! cell differentiation involved in kidney development
created_by: midori
creation_date: 2010-01-25T04:34:31Z

[Term]
id: GO:0072072
name: kidney stroma development
namespace: biological_process
def: "The process whose specific outcome is the progression of the kidney stroma over time, from its formation to the mature structure. The kidney stroma is the mesenchyme of the mature kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0061448 ! connective tissue development
is_a: GO:0072074 ! kidney mesenchyme development
created_by: midori
creation_date: 2010-01-25T04:35:36Z

[Term]
id: GO:0072073
name: kidney epithelium development
namespace: biological_process
def: "The process whose specific outcome is the progression of an epithelium in the kidney over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:mtg_kidney_jan10]
is_a: GO:0060429 ! epithelium development
relationship: part_of GO:0001822 ! kidney development
created_by: midori
creation_date: 2010-01-25T04:37:42Z

[Term]
id: GO:0072074
name: kidney mesenchyme development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a kidney mesenchyme from an initial condition to its mature state. This process begins with the formation of kidney mesenchyme and ends with the mature structure. Kidney mesenchyme is the tissue made up of loosely connected mesenchymal cells in the kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0060485 ! mesenchyme development
relationship: part_of GO:0001822 ! kidney development
created_by: midori
creation_date: 2010-01-25T04:39:04Z

[Term]
id: GO:0072075
name: metanephric mesenchyme development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a metanephric mesenchyme from an initial condition to its mature state. This process begins with the formation of metanephric mesenchyme and ends with the mature structure. Metanephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072074 ! kidney mesenchyme development
relationship: part_of GO:0001656 ! metanephros development
created_by: midori
creation_date: 2010-01-25T04:40:11Z

[Term]
id: GO:0072076
name: nephrogenic mesenchyme development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a nephrogenic mesenchyme from an initial condition to its mature state. This process begins with the formation of nephrogenic mesenchyme and ends with the mature structure. Nephrogenic mesenchyme is the tissue made up of loosely connected mesenchymal cells in the nephron." [GOC:mtg_kidney_jan10]
is_a: GO:0072074 ! kidney mesenchyme development
relationship: part_of GO:0072006 ! nephron development
created_by: midori
creation_date: 2010-01-25T04:40:44Z

[Term]
id: GO:0072077
name: renal vesicle morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the renal vesicle are generated and organized. The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells." [GOC:mtg_kidney_jan10]
is_a: GO:0002009 ! morphogenesis of an epithelium
relationship: part_of GO:0072028 ! nephron morphogenesis
relationship: part_of GO:0072087 ! renal vesicle development
relationship: part_of GO:0072088 ! nephron epithelium morphogenesis
created_by: midori
creation_date: 2010-02-01T02:21:06Z

[Term]
id: GO:0072078
name: nephron tubule morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a nephron tubule are generated and organized. A nephron tubule is an epithelial tube that is part of the nephron, the functional part of the kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0061333 ! renal tubule morphogenesis
is_a: GO:0072088 ! nephron epithelium morphogenesis
relationship: part_of GO:0072080 ! nephron tubule development
created_by: midori
creation_date: 2010-02-01T02:25:14Z

[Term]
id: GO:0072079
name: nephron tubule formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a nephron tubule from unspecified parts. A nephron tubule is an epithelial tube that is part of the nephron, the functional part of the kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0001838 ! embryonic epithelial tube formation
relationship: part_of GO:0072078 ! nephron tubule morphogenesis
created_by: midori
creation_date: 2010-02-01T02:29:26Z

[Term]
id: GO:0072080
name: nephron tubule development
namespace: biological_process
def: "The progression of a nephron tubule over time, from its initial formation to the mature structure. A nephron tubule is an epithelial tube that is part of the nephron, the functional part of the kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0061326 ! renal tubule development
is_a: GO:0072009 ! nephron epithelium development
created_by: midori
creation_date: 2010-02-01T02:32:12Z

[Term]
id: GO:0072081
name: specification of nephron tubule identity
namespace: biological_process
def: "The process in which the tubules arranged along the proximal/distal axis of the nephron acquire their identity." [GOC:bf, GOC:mtg_kidney_jan10]
is_a: GO:0007379 ! segment specification
is_a: GO:0061004 ! pattern specification involved in kidney development
relationship: part_of GO:0072047 ! proximal/distal pattern formation involved in nephron development
relationship: part_of GO:0072079 ! nephron tubule formation
created_by: midori
creation_date: 2010-02-01T02:42:34Z

[Term]
id: GO:0072082
name: specification of proximal tubule identity
namespace: biological_process
def: "The process in which the proximal tubule of the kidney nephron acquires its identity." [GOC:bf, GOC:mtg_kidney_jan10]
is_a: GO:0072081 ! specification of nephron tubule identity
relationship: part_of GO:0072158 ! proximal tubule morphogenesis
created_by: midori
creation_date: 2010-02-01T02:44:34Z

[Term]
id: GO:0072084
name: specification of distal tubule identity
namespace: biological_process
def: "The process in which the distal tubule of the kidney nephron acquires its identity." [GOC:bf, GOC:mtg_kidney_jan10]
is_a: GO:0072081 ! specification of nephron tubule identity
relationship: part_of GO:0072156 ! distal tubule morphogenesis
created_by: midori
creation_date: 2010-02-01T02:47:53Z

[Term]
id: GO:0072085
name: specification of connecting tubule identity
namespace: biological_process
def: "The process in which the connecting tubule of the kidney nephron acquires its identity." [GOC:bf, GOC:mtg_kidney_jan10]
is_a: GO:0072081 ! specification of nephron tubule identity
relationship: part_of GO:0072027 ! connecting tubule development
created_by: midori
creation_date: 2010-02-01T02:49:11Z

[Term]
id: GO:0072086
name: specification of loop of Henle identity
namespace: biological_process
alt_id: GO:0072083
def: "The process in which the loop of Henle of the kidney nephron acquires its identity." [GOC:bf, GOC:mtg_kidney_jan10]
synonym: "specification of intermediate tubule identity" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072081 ! specification of nephron tubule identity
relationship: part_of GO:0072070 ! loop of Henle development
created_by: midori
creation_date: 2010-02-01T02:49:35Z

[Term]
id: GO:0072087
name: renal vesicle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the renal vesicle over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells." [GOC:mtg_kidney_jan10]
is_a: GO:0072073 ! kidney epithelium development
relationship: part_of GO:0072009 ! nephron epithelium development
created_by: midori
creation_date: 2010-02-08T01:18:31Z

[Term]
id: GO:0072088
name: nephron epithelium morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the nephron epithelium are generated and organized. The nephron epithelium is a tissue that covers the surface of a nephron." [GOC:mtg_kidney_jan10]
is_a: GO:0002009 ! morphogenesis of an epithelium
relationship: part_of GO:0072009 ! nephron epithelium development
relationship: part_of GO:0072028 ! nephron morphogenesis
created_by: midori
creation_date: 2010-02-08T01:19:06Z

[Term]
id: GO:0072089
name: stem cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:mtg_kidney_jan10]
is_a: GO:0008283 ! cell proliferation
relationship: has_part GO:0017145 ! stem cell division
created_by: midori
creation_date: 2010-02-08T02:03:36Z

[Term]
id: GO:0072090
name: mesenchymal stem cell proliferation involved in nephron morphogenesis
namespace: biological_process
def: "The multiplication or reproduction of mesenchymal stem cells, resulting in the expansion of a stem cell population, that contributes to the shaping of a nephron." [GOC:mtg_kidney_jan10]
is_a: GO:0097168 ! mesenchymal stem cell proliferation
created_by: midori
creation_date: 2010-02-08T02:05:54Z

[Term]
id: GO:0072091
name: regulation of stem cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of stem cell proliferation. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:mtg_kidney_jan10]
is_a: GO:0042127 ! regulation of cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072089 ! stem cell proliferation
relationship: regulates GO:0072089 ! stem cell proliferation
created_by: midori
creation_date: 2010-02-08T02:09:03Z

[Term]
id: GO:0072092
name: ureteric bud invasion
namespace: biological_process
def: "The process in which the ureteric bud grows along its axis and contributes to the formation of the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0060677 ! ureteric bud elongation
relationship: part_of GO:0072093 ! metanephric renal vesicle formation
created_by: midori
creation_date: 2010-02-10T01:15:13Z

[Term]
id: GO:0072093
name: metanephric renal vesicle formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the metanephros." [GOC:mtg_kidney_jan10]
synonym: "metanephros formation" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072033 ! renal vesicle formation
relationship: part_of GO:0072283 ! metanephric renal vesicle morphogenesis
created_by: midori
creation_date: 2010-02-10T01:17:11Z

[Term]
id: GO:0072094
name: metanephric renal vesicle induction
namespace: biological_process
def: "Signaling at short range between cells of the ureteric bud terminus and the kidney mesenchyme that positively regulates the formation of the metanephric renal vesicle." [GOC:mtg_kidney_jan10]
synonym: "positive regulation of metanephros formation" BROAD [GOC:mtg_kidney_jan10]
is_a: GO:0072034 ! renal vesicle induction
is_a: GO:0072216 ! positive regulation of metanephros development
relationship: positively_regulates GO:0072093 ! metanephric renal vesicle formation
created_by: midori
creation_date: 2010-02-10T01:23:20Z

[Term]
id: GO:0072095
name: regulation of branch elongation involved in ureteric bud branching
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of branch elongation involved in ureteric bud branching, the growth of a branch of the ureteric bud along its axis." [GOC:mtg_kidney_jan10]
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:0090189 ! regulation of branching involved in ureteric bud morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060681 ! branch elongation involved in ureteric bud branching
relationship: regulates GO:0060681 ! branch elongation involved in ureteric bud branching
created_by: midori
creation_date: 2010-02-10T01:41:18Z

[Term]
id: GO:0072096
name: negative regulation of branch elongation involved in ureteric bud branching
namespace: biological_process
def: "Any process that reduces the frequency, rate or extent of branch elongation involved in ureteric bud branching, the growth of a branch of the ureteric bud along its axis." [GOC:mtg_kidney_jan10]
is_a: GO:0048640 ! negative regulation of developmental growth
is_a: GO:0072095 ! regulation of branch elongation involved in ureteric bud branching
is_a: GO:0090191 ! negative regulation of branching involved in ureteric bud morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060681 ! branch elongation involved in ureteric bud branching
relationship: negatively_regulates GO:0060681 ! branch elongation involved in ureteric bud branching
created_by: midori
creation_date: 2010-02-10T01:52:09Z

[Term]
id: GO:0072097
name: negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway
namespace: biological_process
def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor resulting in the reduction of the frequency, rate or extent of branch elongation involved in ureteric bud branching, the growth of a branch of the ureteric bud along its axis." [GOC:mtg_kidney_jan10]
synonym: "negative regulation of branch elongation involved in ureteric bud branching by BMP signalling pathway" EXACT [GOC:mah]
is_a: GO:0030509 ! BMP signaling pathway
is_a: GO:0072096 ! negative regulation of branch elongation involved in ureteric bud branching
intersection_of: GO:0030509 ! BMP signaling pathway
intersection_of: negatively_regulates GO:0060681 ! branch elongation involved in ureteric bud branching
relationship: negatively_regulates GO:0060681 ! branch elongation involved in ureteric bud branching
created_by: midori
creation_date: 2010-02-10T02:00:34Z

[Term]
id: GO:0072098
name: anterior/posterior pattern specification involved in kidney development
namespace: biological_process
def: "The developmental process that results in the creation of defined areas or spaces within the kidney along the anterior/posterior axis to which cells respond and eventually are instructed to differentiate." [GOC:mtg_kidney_jan10]
synonym: "anterior/posterior pattern formation involved in kidney development" RELATED [GOC:mtg_kidney_jan10]
synonym: "kidney anterior/posterior pattern formation" RELATED [GOC:mtg_kidney_jan10]
synonym: "kidney anterior/posterior pattern specification" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0009952 ! anterior/posterior pattern specification
is_a: GO:0061004 ! pattern specification involved in kidney development
intersection_of: GO:0009952 ! anterior/posterior pattern specification
intersection_of: part_of GO:0001822 ! kidney development
relationship: part_of GO:0001822 ! kidney development
created_by: midori
creation_date: 2010-02-10T02:06:24Z

[Term]
id: GO:0072099
name: anterior/posterior pattern specification involved in ureteric bud development
namespace: biological_process
def: "The developmental process that results in the creation of defined areas or spaces within the ureteric bud along the anterior/posterior axis to which cells respond and eventually are instructed to differentiate." [GOC:mtg_kidney_jan10]
synonym: "ureteric bud anterior/posterior pattern formation" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0061227 ! pattern specification involved in mesonephros development
is_a: GO:0072098 ! anterior/posterior pattern specification involved in kidney development
intersection_of: GO:0009952 ! anterior/posterior pattern specification
intersection_of: part_of GO:0001657 ! ureteric bud development
relationship: part_of GO:0001657 ! ureteric bud development
relationship: part_of GO:0072048 ! renal system pattern specification
created_by: midori
creation_date: 2010-02-10T02:12:09Z

[Term]
id: GO:0072100
name: specification of ureteric bud anterior/posterior symmetry
namespace: biological_process
def: "The establishment of the ureteric bud such that there is a similar arrangement in form and relationship of parts along its anterior/posterior axis." [GOC:mtg_kidney_jan10]
synonym: "specification of ureteric bud anterior/posterior asymmetry" EXACT [GOC:dph]
is_a: GO:0009799 ! specification of symmetry
is_a: GO:0072099 ! anterior/posterior pattern specification involved in ureteric bud development
created_by: midori
creation_date: 2010-02-10T02:18:16Z

[Term]
id: GO:0072101
name: specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway
namespace: biological_process
def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that results in the establishment of the ureteric bud such that there is a similar arrangement in form and relationship of parts along its anterior/posterior axis." [GOC:mtg_kidney_jan10]
synonym: "specification of ureteric bud anterior/posterior asymmetry by BMP signaling pathway" EXACT [GOC:dph]
synonym: "specification of ureteric bud anterior/posterior symmetry by BMP signalling pathway" EXACT [GOC:mah]
is_a: GO:0030509 ! BMP signaling pathway
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0061216 ! regulation of transcription from RNA polymerase II promoter involved in mesonephros development
is_a: GO:0072100 ! specification of ureteric bud anterior/posterior symmetry
created_by: midori
creation_date: 2010-02-10T02:21:03Z

[Term]
id: GO:0072102
name: glomerulus morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the glomerulus are generated and organized. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0032835 ! glomerulus development
created_by: midori
creation_date: 2010-02-10T02:32:09Z

[Term]
id: GO:0072103
name: glomerulus vasculature morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the glomerulus vasculature are generated and organized. The glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the glomerulus." [GOC:mtg_kidney_jan10]
is_a: GO:0048514 ! blood vessel morphogenesis
is_a: GO:0061439 ! kidney vasculature morphogenesis
relationship: part_of GO:0072012 ! glomerulus vasculature development
relationship: part_of GO:0072102 ! glomerulus morphogenesis
created_by: midori
creation_date: 2010-02-10T02:34:54Z

[Term]
id: GO:0072104
name: glomerular capillary formation
namespace: biological_process
def: "The process that gives rise to a glomerular capillary. This process pertains to the initial formation of a structure from unspecified parts." [GOC:mtg_kidney_jan10]
is_a: GO:0001525 ! angiogenesis
relationship: part_of GO:0072103 ! glomerulus vasculature morphogenesis
created_by: midori
creation_date: 2010-02-10T02:40:40Z

[Term]
id: GO:0072105
name: ureteric peristalsis
namespace: biological_process
def: "A wavelike sequence of involuntary muscular contraction and relaxation that passes along the ureter, impelling the contents onwards. The ureter is one of a pair of thick-walled tubes that transports urine from the kidney pelvis to the urinary bladder." [GOC:mtg_kidney_jan10]
is_a: GO:0014849 ! ureter smooth muscle contraction
is_a: GO:0030432 ! peristalsis
created_by: midori
creation_date: 2010-02-10T03:07:54Z

[Term]
id: GO:0072106
name: regulation of ureteric bud formation
namespace: biological_process
def: "Any process that modulates the developmental process pertaining to the initial formation of the ureteric bud from the Wolffian duct." [GOC:mtg_kidney_jan10]
is_a: GO:0045995 ! regulation of embryonic development
is_a: GO:0061217 ! regulation of mesonephros development
is_a: GO:2000027 ! regulation of organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060676 ! ureteric bud formation
relationship: regulates GO:0060676 ! ureteric bud formation
created_by: midori
creation_date: 2010-02-12T02:34:40Z

[Term]
id: GO:0072107
name: positive regulation of ureteric bud formation
namespace: biological_process
def: "Any process that increases the rate or extent of the developmental process pertaining to the initial formation of the ureteric bud from the Wolffian duct." [GOC:mtg_kidney_jan10]
is_a: GO:0040019 ! positive regulation of embryonic development
is_a: GO:0061213 ! positive regulation of mesonephros development
is_a: GO:0072106 ! regulation of ureteric bud formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060676 ! ureteric bud formation
relationship: positively_regulates GO:0060676 ! ureteric bud formation
created_by: midori
creation_date: 2010-02-12T02:37:28Z

[Term]
id: GO:0072108
name: positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0003339 ! regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
is_a: GO:0010770 ! positive regulation of cell morphogenesis involved in differentiation
is_a: GO:0030858 ! positive regulation of epithelial cell differentiation
is_a: GO:0072216 ! positive regulation of metanephros development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003337 ! mesenchymal to epithelial transition involved in metanephros morphogenesis
relationship: positively_regulates GO:0003337 ! mesenchymal to epithelial transition involved in metanephros morphogenesis
created_by: midori
creation_date: 2010-02-12T02:45:57Z

[Term]
id: GO:0072109
name: glomerular mesangium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the glomerular mesangium over time, from its formation to the mature structure. The glomerular mesangium is the thin membrane connective tissue composed of mesangial cells, which helps to support the capillary loops in a renal glomerulus." [GOC:mtg_kidney_jan10]
is_a: GO:0061448 ! connective tissue development
relationship: part_of GO:0072012 ! glomerulus vasculature development
created_by: midori
creation_date: 2010-02-22T10:35:24Z

[Term]
id: GO:0072110
name: glomerular mesangial cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of glomerular mesangial cells, resulting in the expansion of the population." [GOC:mtg_kidney_jan10]
is_a: GO:0072111 ! cell proliferation involved in kidney development
relationship: part_of GO:0072109 ! glomerular mesangium development
created_by: midori
creation_date: 2010-02-22T10:45:47Z

[Term]
id: GO:0072111
name: cell proliferation involved in kidney development
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of the population in the kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0008283 ! cell proliferation
intersection_of: GO:0008283 ! cell proliferation
intersection_of: part_of GO:0001822 ! kidney development
relationship: part_of GO:0001822 ! kidney development
created_by: midori
creation_date: 2010-02-22T10:48:45Z

[Term]
id: GO:0072112
name: glomerular visceral epithelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a glomerular visceral epithelial cell. A glomerular visceral epithelial cell is a specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells." [GOC:mtg_kidney_jan10]
synonym: "podocyte differentiation" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0061318 ! renal filtration cell differentiation
is_a: GO:0072311 ! glomerular epithelial cell differentiation
created_by: midori
creation_date: 2010-02-22T10:52:11Z

[Term]
id: GO:0072113
name: head kidney development
namespace: biological_process
def: "The process whose specific outcome is the progression of the head kidney over time, from its formation to the mature structure. The head kidney is a pronephros that consists of fused bilateral lobes located in the anterior part of the kidney. It is analogous to the mammalian bone marrow and the primary site of definitive hematopoiesis." [GOC:mtg_kidney_jan10, ZFA:0000669]
is_a: GO:0048534 ! hematopoietic or lymphoid organ development
is_a: GO:0048793 ! pronephros development
created_by: midori
creation_date: 2010-02-22T11:09:38Z

[Term]
id: GO:0072114
name: pronephros morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the pronephros are generated and organized. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life." [GOC:mtg_kidney_jan10]
synonym: "pronephric kidney morphogenesis" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0060993 ! kidney morphogenesis
relationship: part_of GO:0048793 ! pronephros development
created_by: midori
creation_date: 2010-02-22T11:12:15Z

[Term]
id: GO:0072115
name: head kidney morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the head kidney are generated and organized. The head kidney is a pronephros that consists of fused bilateral lobes located in the anterior part of the kidney." [GOC:mtg_kidney_jan10, ZFA:0000669]
is_a: GO:0072114 ! pronephros morphogenesis
relationship: part_of GO:0072113 ! head kidney development
created_by: midori
creation_date: 2010-02-22T11:13:37Z

[Term]
id: GO:0072116
name: pronephros formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the pronephros. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life." [GOC:mtg_kidney_jan10]
synonym: "pronephric kidney formation" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0048645 ! organ formation
is_a: GO:0072003 ! kidney rudiment formation
relationship: part_of GO:0072114 ! pronephros morphogenesis
created_by: midori
creation_date: 2010-02-22T11:16:26Z

[Term]
id: GO:0072117
name: head kidney formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the head kidney. The head kidney is a pronephros that consists of fused bilateral lobes located in the anterior part of the kidney." [GOC:mtg_kidney_jan10, ZFA:0000669]
is_a: GO:0072116 ! pronephros formation
relationship: part_of GO:0072115 ! head kidney morphogenesis
created_by: midori
creation_date: 2010-02-22T11:17:20Z

[Term]
id: GO:0072118
name: pronephros structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the pronephros. This process pertains to the physical shaping of a rudimentary structure. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life." [GOC:mtg_kidney_jan10]
synonym: "pronephric kidney structural organization" EXACT [GOC:mtg_kidney_jan10]
synonym: "pronephros structural organisation" EXACT [GOC:mah]
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0072114 ! pronephros morphogenesis
created_by: midori
creation_date: 2010-02-22T11:21:38Z

[Term]
id: GO:0072119
name: head kidney structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the head kidney. This process pertains to the physical shaping of a rudimentary structure. The head kidney is a pronephros that consists of fused bilateral lobes located in the anterior part of the kidney." [GOC:mtg_kidney_jan10, ZFA:0000669]
synonym: "head kidney structural organisation" EXACT [GOC:mah]
is_a: GO:0072118 ! pronephros structural organization
relationship: part_of GO:0072115 ! head kidney morphogenesis
created_by: midori
creation_date: 2010-02-22T11:22:12Z

[Term]
id: GO:0072120
name: pronephros maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the pronephros to attain its fully functional state. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life." [GOC:mtg_kidney_jan10]
synonym: "pronephric kidney maturation" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0048799 ! organ maturation
relationship: part_of GO:0048793 ! pronephros development
created_by: midori
creation_date: 2010-02-22T11:25:48Z

[Term]
id: GO:0072121
name: head kidney maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the head kidney to attain its fully functional state. The head kidney is a pronephros that consists of fused bilateral lobes located in the anterior part of the kidney." [GOC:mtg_kidney_jan10, ZFA:0000669]
is_a: GO:0072120 ! pronephros maturation
relationship: part_of GO:0072113 ! head kidney development
created_by: midori
creation_date: 2010-02-22T11:28:08Z

[Term]
id: GO:0072122
name: extraglomerular mesangial cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of extraglomerular glomerular mesangium cells by cell division, resulting in the expansion of their population. Extraglomerular mesangial cells (also known as lacis cells, Goormaghtigh cells) are light-staining cells in the kidney found outside the glomerulus, near the vascular pole and macula densa." [GOC:mtg_kidney_jan10]
synonym: "Goormaghtigh proliferation" RELATED [GOC:mtg_kidney_jan10]
synonym: "lacis cell proliferation" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0072111 ! cell proliferation involved in kidney development
relationship: part_of GO:0072006 ! nephron development
created_by: midori
creation_date: 2010-02-22T01:42:23Z

[Term]
id: GO:0072123
name: intraglomerular mesangial cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of intraglomerular glomerular mesangium cells by cell division, resulting in the expansion of their population. Intraglomerular mesangial cells are specialized pericytes located among the glomerular capillaries within a renal corpuscle of a kidney. They are required for filtration, structural support and phagocytosis." [GOC:mtg_kidney_jan10]
is_a: GO:0072110 ! glomerular mesangial cell proliferation
created_by: midori
creation_date: 2010-02-22T01:44:29Z

[Term]
id: GO:0072124
name: regulation of glomerular mesangial cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glomerular mesangial cell proliferation." [GOC:mtg_kidney_jan10]
is_a: GO:0090192 ! regulation of glomerulus development
is_a: GO:1901342 ! regulation of vasculature development
is_a: GO:1901722 ! regulation of cell proliferation involved in kidney development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072110 ! glomerular mesangial cell proliferation
relationship: regulates GO:0072110 ! glomerular mesangial cell proliferation
created_by: midori
creation_date: 2010-02-22T01:46:12Z

[Term]
id: GO:0072125
name: negative regulation of glomerular mesangial cell proliferation
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of glomerular mesangial cell proliferation." [GOC:mtg_kidney_jan10]
is_a: GO:0072124 ! regulation of glomerular mesangial cell proliferation
is_a: GO:0090194 ! negative regulation of glomerulus development
is_a: GO:1901343 ! negative regulation of vasculature development
is_a: GO:1901723 ! negative regulation of cell proliferation involved in kidney development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072110 ! glomerular mesangial cell proliferation
relationship: negatively_regulates GO:0072110 ! glomerular mesangial cell proliferation
created_by: midori
creation_date: 2010-02-22T01:48:49Z

[Term]
id: GO:0072126
name: positive regulation of glomerular mesangial cell proliferation
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of glomerular mesangial cell proliferation." [GOC:mtg_kidney_jan10]
is_a: GO:0072124 ! regulation of glomerular mesangial cell proliferation
is_a: GO:0090193 ! positive regulation of glomerulus development
is_a: GO:1901724 ! positive regulation of cell proliferation involved in kidney development
is_a: GO:1904018 ! positive regulation of vasculature development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072110 ! glomerular mesangial cell proliferation
relationship: positively_regulates GO:0072110 ! glomerular mesangial cell proliferation
created_by: midori
creation_date: 2010-02-22T01:49:31Z

[Term]
id: GO:0072127
name: renal capsule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the renal capsule over time, from its formation to the mature structure. The renal capsule is the tough fibrous layer surrounding the kidney, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage. During development, it comprises a single layer of flattened cells that lie just above the cortical stroma and the condensed mesenchyme of the nephrogenic zone. It is in this region that the early stages of nephron induction and formation of new generations ureteric bud branches occur, as the kidney expands." [GOC:mtg_kidney_jan10]
is_a: GO:0061448 ! connective tissue development
relationship: part_of GO:0001822 ! kidney development
created_by: midori
creation_date: 2010-02-22T02:02:55Z

[Term]
id: GO:0072128
name: renal capsule morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the renal capsule are generated and organized. The renal capsule is the tough fibrous layer surrounding the kidney, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage. During development, it comprises a single layer of flattened cells that lie just above the cortical stroma and the condensed mesenchyme of the nephrogenic zone. It is in this region that the early stages of nephron induction and formation of new generations ureteric bud branches occur, as the kidney expands." [GOC:mtg_kidney_jan10]
is_a: GO:0048729 ! tissue morphogenesis
relationship: part_of GO:0072127 ! renal capsule development
created_by: midori
creation_date: 2010-02-22T02:06:19Z

[Term]
id: GO:0072129
name: renal capsule formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a renal capsule from unspecified parts. The renal capsule is the tough fibrous layer surrounding the kidney, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage. During development, it comprises a single layer of flattened cells that lie just above the cortical stroma and the condensed mesenchyme of the nephrogenic zone. It is in this region that the early stages of nephron induction and formation of new generations ureteric bud branches occur, as the kidney expands." [GOC:mtg_kidney_jan10]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0072128 ! renal capsule morphogenesis
created_by: midori
creation_date: 2010-02-22T02:08:14Z

[Term]
id: GO:0072130
name: renal capsule specification
namespace: biological_process
def: "The regionalization process in which the identity of the renal capsule is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:mtg_kidney_jan10]
is_a: GO:0003002 ! regionalization
is_a: GO:0061004 ! pattern specification involved in kidney development
relationship: part_of GO:0072129 ! renal capsule formation
created_by: midori
creation_date: 2010-02-22T02:12:34Z

[Term]
id: GO:0072131
name: kidney mesenchyme morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a kidney mesenchymal tissue are generated and organized. Kidney mesenchyme is the tissue made up of loosely connected mesenchymal cells in the kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0072132 ! mesenchyme morphogenesis
relationship: part_of GO:0072074 ! kidney mesenchyme development
created_by: midori
creation_date: 2010-02-22T02:16:43Z

[Term]
id: GO:0072132
name: mesenchyme morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a mesenchymal tissue are generated and organized. A mesenchymal tissue is made up of loosely packed stellate cells." [GOC:mtg_kidney_jan10]
is_a: GO:0048729 ! tissue morphogenesis
relationship: part_of GO:0009887 ! organ morphogenesis
relationship: part_of GO:0060485 ! mesenchyme development
created_by: midori
creation_date: 2010-02-22T02:17:15Z

[Term]
id: GO:0072133
name: metanephric mesenchyme morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a metanephric mesenchymal tissue are generated and organized. Metanephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072131 ! kidney mesenchyme morphogenesis
relationship: part_of GO:0072075 ! metanephric mesenchyme development
created_by: midori
creation_date: 2010-02-22T02:20:14Z

[Term]
id: GO:0072134
name: nephrogenic mesenchyme morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a nephrogenic mesenchymal tissue are generated and organized. Nephrogenic mesenchyme is the tissue made up of loosely connected mesenchymal cells in the nephron." [GOC:mtg_kidney_jan10]
is_a: GO:0072131 ! kidney mesenchyme morphogenesis
relationship: part_of GO:0072076 ! nephrogenic mesenchyme development
created_by: midori
creation_date: 2010-02-22T02:21:16Z

[Term]
id: GO:0072135
name: kidney mesenchymal cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population in the kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0010463 ! mesenchymal cell proliferation
is_a: GO:0072111 ! cell proliferation involved in kidney development
relationship: part_of GO:0072074 ! kidney mesenchyme development
created_by: midori
creation_date: 2010-02-22T02:33:10Z

[Term]
id: GO:0072136
name: metanephric mesenchymal cell proliferation involved in metanephros development
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a metanephric mesenchymal cell population." [GOC:mtg_kidney_jan10]
is_a: GO:0072135 ! kidney mesenchymal cell proliferation
is_a: GO:0072203 ! cell proliferation involved in metanephros development
relationship: part_of GO:0072075 ! metanephric mesenchyme development
created_by: midori
creation_date: 2010-02-22T02:34:56Z

[Term]
id: GO:0072137
name: condensed mesenchymal cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a condensed mesenchymal cell population. A condensed mesenchymal cell population is a population of adherent mesenchymal cells." [GOC:mtg_kidney_jan10]
is_a: GO:0010463 ! mesenchymal cell proliferation
created_by: midori
creation_date: 2010-02-22T02:38:54Z

[Term]
id: GO:0072138
name: mesenchymal cell proliferation involved in ureteric bud development
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population of the ureteric bud, that contributes to ureteric bud development." [GOC:mtg_kidney_jan10]
synonym: "ureteric bud mesenchymal cell proliferation" BROAD [GOC:mtg_kidney_jan10]
is_a: GO:0010463 ! mesenchymal cell proliferation
is_a: GO:0061209 ! cell proliferation involved in mesonephros development
intersection_of: GO:0010463 ! mesenchymal cell proliferation
intersection_of: part_of GO:0001657 ! ureteric bud development
relationship: part_of GO:0001657 ! ureteric bud development
created_by: midori
creation_date: 2010-02-22T02:40:38Z

[Term]
id: GO:0072139
name: glomerular parietal epithelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a glomerular parietal epithelial cell. Glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport." [GOC:mtg_kidney_jan10]
is_a: GO:0072311 ! glomerular epithelial cell differentiation
created_by: midori
creation_date: 2010-02-24T01:33:05Z

[Term]
id: GO:0072140
name: DCT cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a distal convoluted tubule cell over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10]
synonym: "distal convoluted tubule cell development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0072069 ! DCT cell differentiation
created_by: midori
creation_date: 2010-02-24T01:36:21Z

[Term]
id: GO:0072141
name: renal interstitial fibroblast development
namespace: biological_process
def: "The process whose specific outcome is the progression of a renal interstitial fibroblast over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10]
synonym: "kidney interstitial cell development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0072071 ! kidney interstitial fibroblast differentiation
created_by: midori
creation_date: 2010-02-24T01:39:05Z

[Term]
id: GO:0072142
name: juxtaglomerulus cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a juxtaglomerulus cell over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0072052 ! juxtaglomerulus cell differentiation
created_by: midori
creation_date: 2010-02-24T01:42:53Z

[Term]
id: GO:0072143
name: mesangial cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a mesangial cell in the kidney over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0072007 ! mesangial cell differentiation
created_by: midori
creation_date: 2010-02-24T01:44:28Z

[Term]
id: GO:0072144
name: glomerular mesangial cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a glomerular mesangial cell in the kidney over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10]
is_a: GO:0002064 ! epithelial cell development
is_a: GO:0072141 ! renal interstitial fibroblast development
is_a: GO:0072143 ! mesangial cell development
relationship: part_of GO:0072008 ! glomerular mesangial cell differentiation
created_by: midori
creation_date: 2010-02-24T01:53:13Z

[Term]
id: GO:0072145
name: proximal convoluted tubule segment 1 cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of an S1 cell in the kidney over time, from its formation to the mature structure." [GOC:bf, GOC:mtg_kidney_jan10]
synonym: "S1 cell development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0072062 ! proximal convoluted tubule segment 1 cell differentiation
created_by: midori
creation_date: 2010-02-24T01:54:56Z

[Term]
id: GO:0072146
name: DCT cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a distal convoluted tubule cell." [GOC:mtg_kidney_jan10]
synonym: "distal convoluted tubule cell fate commitment" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0072069 ! DCT cell differentiation
created_by: midori
creation_date: 2010-02-24T01:59:04Z

[Term]
id: GO:0072147
name: glomerular parietal epithelial cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a glomerular parietal epithelial cell. Glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. These cells may also give rise to podocytes." [GOC:mtg_kidney_jan10]
synonym: "Bowman's capsule cell fate commitment" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072148 ! epithelial cell fate commitment
is_a: GO:0072314 ! glomerular epithelial cell fate commitment
relationship: part_of GO:0072139 ! glomerular parietal epithelial cell differentiation
created_by: midori
creation_date: 2010-02-24T02:00:52Z

[Term]
id: GO:0072148
name: epithelial cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into an epithelial cell." [GOC:mtg_kidney_jan10]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0030855 ! epithelial cell differentiation
created_by: midori
creation_date: 2010-02-24T02:05:03Z

[Term]
id: GO:0072149
name: glomerular visceral epithelial cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a glomerular visceral epithelial cell. A glomerular visceral epithelial cell is a specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells." [GOC:mtg_kidney_jan10]
synonym: "podocyte cell fate commitment" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0072148 ! epithelial cell fate commitment
is_a: GO:0072314 ! glomerular epithelial cell fate commitment
relationship: part_of GO:0072112 ! glomerular visceral epithelial cell differentiation
created_by: midori
creation_date: 2010-02-24T02:08:03Z

[Term]
id: GO:0072150
name: juxtaglomerulus cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a juxtaglomerulus cell." [GOC:mtg_kidney_jan10]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0072052 ! juxtaglomerulus cell differentiation
created_by: midori
creation_date: 2010-02-24T02:09:49Z

[Term]
id: GO:0072151
name: mesangial cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesangial cell." [GOC:mtg_kidney_jan10]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0072007 ! mesangial cell differentiation
created_by: midori
creation_date: 2010-02-24T02:11:13Z

[Term]
id: GO:0072152
name: glomerular mesangial cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a glomerular mesangial cell." [GOC:mtg_kidney_jan10]
is_a: GO:0072151 ! mesangial cell fate commitment
relationship: part_of GO:0072008 ! glomerular mesangial cell differentiation
created_by: midori
creation_date: 2010-02-24T02:14:58Z

[Term]
id: GO:0072153
name: renal interstitial fibroblast fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a renal fibroblast." [GOC:mtg_kidney_jan10]
synonym: "kidney interstitial cell fate commitment" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0072071 ! kidney interstitial fibroblast differentiation
created_by: midori
creation_date: 2010-02-24T02:16:53Z

[Term]
id: GO:0072154
name: proximal convoluted tubule segment 1 cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into an S1 cell in the kidney." [GOC:bf, GOC:mtg_kidney_jan10]
synonym: "S1 cell fate commitment" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0072062 ! proximal convoluted tubule segment 1 cell differentiation
created_by: midori
creation_date: 2010-02-24T02:18:19Z

[Term]
id: GO:0072155
name: epithelial cell migration involved in nephron tubule morphogenesis
namespace: biological_process
def: "The orderly movement of epithelial cells within a renal tubule that contributes to nephron tubule morphogenesis." [GOC:mtg_kidney_jan10]
is_a: GO:0010631 ! epithelial cell migration
is_a: GO:0035787 ! cell migration involved in kidney development
intersection_of: GO:0010631 ! epithelial cell migration
intersection_of: part_of GO:0072078 ! nephron tubule morphogenesis
relationship: part_of GO:0072078 ! nephron tubule morphogenesis
created_by: midori
creation_date: 2010-02-24T02:21:25Z

[Term]
id: GO:0072156
name: distal tubule morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a distal tubule are generated and organized. The distal tubule is a nephron tubule that begins at the macula densa and extends to the connecting tubule." [GOC:mtg_kidney_jan10]
is_a: GO:0072078 ! nephron tubule morphogenesis
relationship: part_of GO:0072017 ! distal tubule development
created_by: midori
creation_date: 2010-02-24T02:32:03Z

[Term]
id: GO:0072157
name: epithelial cell migration involved in distal tubule morphogenesis
namespace: biological_process
def: "The orderly movement of epithelial cells within a renal tubule that contributes to distal tubule morphogenesis." [GOC:mtg_kidney_jan10]
is_a: GO:0072155 ! epithelial cell migration involved in nephron tubule morphogenesis
intersection_of: GO:0010631 ! epithelial cell migration
intersection_of: part_of GO:0072156 ! distal tubule morphogenesis
relationship: part_of GO:0072156 ! distal tubule morphogenesis
created_by: midori
creation_date: 2010-02-24T02:33:33Z

[Term]
id: GO:0072158
name: proximal tubule morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a proximal tubule are generated and organized. The proximal tubule is a nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle. It has a brush border epithelial morphology." [GOC:mtg_kidney_jan10]
is_a: GO:0072078 ! nephron tubule morphogenesis
relationship: part_of GO:0072014 ! proximal tubule development
created_by: midori
creation_date: 2010-02-24T02:35:36Z

[Term]
id: GO:0072159
name: epithelial cell migration involved in proximal tubule morphogenesis
namespace: biological_process
def: "The orderly movement of epithelial cells within a renal tubule that contributes to proximal tubule morphogenesis." [GOC:mtg_kidney_jan10]
is_a: GO:0072155 ! epithelial cell migration involved in nephron tubule morphogenesis
intersection_of: GO:0010631 ! epithelial cell migration
intersection_of: part_of GO:0072158 ! proximal tubule morphogenesis
relationship: part_of GO:0072158 ! proximal tubule morphogenesis
created_by: midori
creation_date: 2010-02-24T02:37:08Z

[Term]
id: GO:0072160
name: nephron tubule epithelial cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the nephron tubule as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
is_a: GO:0035850 ! epithelial cell differentiation involved in kidney development
relationship: part_of GO:0072080 ! nephron tubule development
created_by: midori
creation_date: 2010-02-24T02:40:11Z

[Term]
id: GO:0072161
name: mesenchymal cell differentiation involved in kidney development
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the kidney as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
is_a: GO:0061005 ! cell differentiation involved in kidney development
is_a: GO:2001012 ! mesenchymal cell differentiation involved in renal system development
intersection_of: GO:0048762 ! mesenchymal cell differentiation
intersection_of: part_of GO:0001822 ! kidney development
relationship: part_of GO:0001822 ! kidney development
relationship: part_of GO:0072074 ! kidney mesenchyme development
created_by: midori
creation_date: 2010-02-26T01:31:49Z

[Term]
id: GO:0072162
name: metanephric mesenchymal cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the metanephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
is_a: GO:0072161 ! mesenchymal cell differentiation involved in kidney development
is_a: GO:0072202 ! cell differentiation involved in metanephros development
relationship: part_of GO:0072075 ! metanephric mesenchyme development
created_by: midori
creation_date: 2010-02-26T01:35:00Z

[Term]
id: GO:0072163
name: mesonephric epithelium development
namespace: biological_process
def: "The process whose specific outcome is the progression of an epithelium in the mesonephros over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:mtg_kidney_jan10]
is_a: GO:0072073 ! kidney epithelium development
relationship: part_of GO:0001823 ! mesonephros development
created_by: midori
creation_date: 2010-02-26T01:40:43Z

[Term]
id: GO:0072164
name: mesonephric tubule development
namespace: biological_process
def: "The progression of a mesonephric tubule over time, from its initial formation to the mature structure. A mesonephric tubule is an epithelial tube that is part of the mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0035295 ! tube development
is_a: GO:0072163 ! mesonephric epithelium development
created_by: midori
creation_date: 2010-02-26T01:45:58Z

[Term]
id: GO:0072165
name: anterior mesonephric tubule development
namespace: biological_process
def: "The progression of the anterior mesonephric tubule over time, from its initial formation to the mature structure. The anterior mesonephric tubule is an epithelial tube that is part of the mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072164 ! mesonephric tubule development
created_by: midori
creation_date: 2010-02-26T01:47:26Z

[Term]
id: GO:0072166
name: posterior mesonephric tubule development
namespace: biological_process
def: "The progression of the posterior mesonephric tubule over time, from its initial formation to the mature structure. The posterior mesonephric tubule is an epithelial tube that is part of the mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072164 ! mesonephric tubule development
created_by: midori
creation_date: 2010-02-26T01:47:50Z

[Term]
id: GO:0072167
name: specification of mesonephric tubule identity
namespace: biological_process
def: "The process in which the tubules of the mesonephros acquire their identity." [GOC:mtg_kidney_jan10]
is_a: GO:0061227 ! pattern specification involved in mesonephros development
is_a: GO:0072081 ! specification of nephron tubule identity
relationship: part_of GO:0072172 ! mesonephric tubule formation
created_by: midori
creation_date: 2010-02-26T01:51:03Z

[Term]
id: GO:0072168
name: specification of anterior mesonephric tubule identity
namespace: biological_process
def: "The process in which the tubules of the anterior mesonephros acquire their identity." [GOC:mtg_kidney_jan10]
is_a: GO:0072098 ! anterior/posterior pattern specification involved in kidney development
is_a: GO:0072167 ! specification of mesonephric tubule identity
relationship: part_of GO:0072165 ! anterior mesonephric tubule development
created_by: midori
creation_date: 2010-02-26T01:52:36Z

[Term]
id: GO:0072169
name: specification of posterior mesonephric tubule identity
namespace: biological_process
def: "The process in which the tubules of the posterior mesonephros acquire their identity." [GOC:mtg_kidney_jan10]
is_a: GO:0072098 ! anterior/posterior pattern specification involved in kidney development
is_a: GO:0072167 ! specification of mesonephric tubule identity
relationship: part_of GO:0072166 ! posterior mesonephric tubule development
created_by: midori
creation_date: 2010-02-26T01:54:06Z

[Term]
id: GO:0072170
name: metanephric tubule development
namespace: biological_process
def: "The progression of a metanephric tubule over time, from its initial formation to the mature structure. A metanephric tubule is an epithelial tube that is part of the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0035295 ! tube development
is_a: GO:0072207 ! metanephric epithelium development
relationship: part_of GO:0001656 ! metanephros development
created_by: midori
creation_date: 2010-02-26T01:58:18Z

[Term]
id: GO:0072171
name: mesonephric tubule morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a mesonephric tubule are generated and organized. A mesonephric tubule is an epithelial tube that is part of the mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072078 ! nephron tubule morphogenesis
relationship: part_of GO:0072164 ! mesonephric tubule development
created_by: midori
creation_date: 2010-02-26T02:02:13Z

[Term]
id: GO:0072172
name: mesonephric tubule formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a mesonephric tubule from unspecified parts. A mesonephric tubule is an epithelial tube that is part of the mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072079 ! nephron tubule formation
relationship: part_of GO:0072171 ! mesonephric tubule morphogenesis
created_by: midori
creation_date: 2010-02-26T02:02:37Z

[Term]
id: GO:0072173
name: metanephric tubule morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a metanephric tubule are generated and organized from an epithelium. A metanephric tubule is an epithelial tube that is part of the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0060562 ! epithelial tube morphogenesis
relationship: part_of GO:0072170 ! metanephric tubule development
created_by: midori
creation_date: 2010-02-26T02:06:42Z

[Term]
id: GO:0072174
name: metanephric tubule formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a metanephric tubule." [GOC:mtg_kidney_jan10]
is_a: GO:0072175 ! epithelial tube formation
relationship: part_of GO:0072173 ! metanephric tubule morphogenesis
created_by: midori
creation_date: 2010-02-26T02:07:41Z

[Term]
id: GO:0072175
name: epithelial tube formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of an epithelial tube." [GOC:mtg_kidney_jan10]
is_a: GO:0035148 ! tube formation
relationship: part_of GO:0060562 ! epithelial tube morphogenesis
created_by: midori
creation_date: 2010-02-26T02:15:40Z

[Term]
id: GO:0072176
name: nephric duct development
namespace: biological_process
def: "The process whose specific outcome is the progression of a nephric duct over time, from its initial formation to a mature structure. A nephric duct is a tube that drains a primitive kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0035295 ! tube development
is_a: GO:0072073 ! kidney epithelium development
created_by: midori
creation_date: 2010-02-26T02:27:31Z

[Term]
id: GO:0072177
name: mesonephric duct development
namespace: biological_process
def: "The process whose specific outcome is the progression of a mesonephric duct over time, from its initial formation to a mature structure. A mesonephric duct is a tube drains the mesonephros." [GOC:mtg_kidney_jan10]
synonym: "Wolffian duct development" EXACT [GOC:dph]
is_a: GO:0072164 ! mesonephric tubule development
is_a: GO:0072176 ! nephric duct development
created_by: midori
creation_date: 2010-02-26T02:32:22Z

[Term]
id: GO:0072178
name: nephric duct morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the nephric duct are generated and organized. A nephric duct is a tube that drains a primitive kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0060562 ! epithelial tube morphogenesis
relationship: part_of GO:0072176 ! nephric duct development
created_by: midori
creation_date: 2010-02-26T02:35:29Z

[Term]
id: GO:0072179
name: nephric duct formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a nephric duct. A nephric duct is a tube that drains a primitive kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0072175 ! epithelial tube formation
relationship: part_of GO:0072178 ! nephric duct morphogenesis
created_by: midori
creation_date: 2010-02-26T02:35:55Z

[Term]
id: GO:0072180
name: mesonephric duct morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the mesonephric duct are generated and organized. A mesonephric duct is a tube drains the mesonephros." [GOC:mtg_kidney_jan10]
synonym: "Wolffian duct morphogenesis" RELATED [GOC:dph]
is_a: GO:0072171 ! mesonephric tubule morphogenesis
is_a: GO:0072178 ! nephric duct morphogenesis
relationship: part_of GO:0072177 ! mesonephric duct development
created_by: midori
creation_date: 2010-02-26T02:37:13Z

[Term]
id: GO:0072181
name: mesonephric duct formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a mesonephric duct. A mesonephric duct is a tube that drains the mesonephros." [GOC:mtg_kidney_jan10]
synonym: "Wolffian duct formation" EXACT [GOC:dph]
is_a: GO:0072172 ! mesonephric tubule formation
is_a: GO:0072179 ! nephric duct formation
is_a: GO:0072180 ! mesonephric duct morphogenesis
created_by: midori
creation_date: 2010-02-26T02:38:03Z

[Term]
id: GO:0072182
name: regulation of nephron tubule epithelial cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nephron tubule epithelial cell differentiation." [GOC:mtg_kidney_jan10]
is_a: GO:2000696 ! regulation of epithelial cell differentiation involved in kidney development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072160 ! nephron tubule epithelial cell differentiation
relationship: regulates GO:0072160 ! nephron tubule epithelial cell differentiation
created_by: midori
creation_date: 2010-02-26T02:45:09Z

[Term]
id: GO:0072183
name: negative regulation of nephron tubule epithelial cell differentiation
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of nephron tubule epithelial cell differentiation." [GOC:mtg_kidney_jan10]
is_a: GO:0072182 ! regulation of nephron tubule epithelial cell differentiation
is_a: GO:2000697 ! negative regulation of epithelial cell differentiation involved in kidney development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072160 ! nephron tubule epithelial cell differentiation
relationship: negatively_regulates GO:0072160 ! nephron tubule epithelial cell differentiation
created_by: midori
creation_date: 2010-02-26T02:47:25Z

[Term]
id: GO:0072184
name: renal vesicle progenitor cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the renal vesicle progenitor cells of the kidney as it progresses from its formation to the mature state. A renal vesicle progenitor cell is a cell that will give rise to terminally differentiated cells of the renal vesicle without self-renewing." [GOC:mtg_kidney_jan10]
is_a: GO:0061005 ! cell differentiation involved in kidney development
relationship: part_of GO:0072087 ! renal vesicle development
created_by: midori
creation_date: 2010-02-26T02:52:54Z

[Term]
id: GO:0072185
name: metanephric cap development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of the metanephric cap from an initial condition to its mature state. The metanephric cap is formed by the condensation of metanephric mesenchymal cells surrounding the ureteric bud tip." [GOC:mtg_kidney_jan10]
is_a: GO:0072075 ! metanephric mesenchyme development
created_by: midori
creation_date: 2010-03-01T01:20:22Z

[Term]
id: GO:0072186
name: metanephric cap morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the metanephric cap are generated and organized. The metanephric cap is formed by the condensation of metanephric mesenchymal cells surrounding the ureteric bud tip." [GOC:mtg_kidney_jan10]
is_a: GO:0072133 ! metanephric mesenchyme morphogenesis
relationship: part_of GO:0072185 ! metanephric cap development
created_by: midori
creation_date: 2010-03-01T01:22:51Z

[Term]
id: GO:0072187
name: metanephric cap formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a metanephric cap from unspecified parts. The metanephric cap is formed by the condensation of metanephric mesenchymal cells surrounding the ureteric bud tip." [GOC:mtg_kidney_jan10]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0072186 ! metanephric cap morphogenesis
created_by: midori
creation_date: 2010-03-01T01:26:53Z

[Term]
id: GO:0072188
name: metanephric cap specification
namespace: biological_process
def: "The process in which the metanephric cap acquires its identity." [GOC:mtg_kidney_jan10]
is_a: GO:0072048 ! renal system pattern specification
is_a: GO:0072187 ! metanephric cap formation
is_a: GO:0072268 ! pattern specification involved in metanephros development
created_by: midori
creation_date: 2010-03-01T01:35:25Z

[Term]
id: GO:0072189
name: ureter development
namespace: biological_process
def: "The process whose specific outcome is the progression of the ureter over time, from its formation to the mature structure. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder or from the Malpighian tubule to the hindgut." [GOC:mtg_kidney_jan10]
is_a: GO:0035295 ! tube development
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048513 ! animal organ development
relationship: part_of GO:0072001 ! renal system development
created_by: midori
creation_date: 2010-03-01T01:44:14Z

[Term]
id: GO:0072190
name: ureter urothelium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the urothelium of the ureter over time, from its formation to the mature structure. The urothelium is an epithelium that makes up the epithelial tube of the ureter." [GOC:mtg_kidney_jan10]
synonym: "ureter epithelium development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0060429 ! epithelium development
relationship: part_of GO:0072189 ! ureter development
created_by: midori
creation_date: 2010-03-01T01:46:31Z

[Term]
id: GO:0072191
name: ureter smooth muscle development
namespace: biological_process
def: "The process whose specific outcome is the progression of smooth muscle in the ureter over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10]
is_a: GO:0048745 ! smooth muscle tissue development
relationship: part_of GO:0072189 ! ureter development
created_by: midori
creation_date: 2010-03-01T01:48:53Z

[Term]
id: GO:0072192
name: ureter epithelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell in the urothelium. The urothelium is the epithelial tube of the ureter." [GOC:mtg_kidney_jan10]
is_a: GO:0030855 ! epithelial cell differentiation
relationship: part_of GO:0072190 ! ureter urothelium development
created_by: midori
creation_date: 2010-03-01T01:53:17Z

[Term]
id: GO:0072193
name: ureter smooth muscle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell in the ureter." [GOC:mtg_kidney_jan10]
is_a: GO:0051145 ! smooth muscle cell differentiation
relationship: part_of GO:0072191 ! ureter smooth muscle development
created_by: midori
creation_date: 2010-03-01T01:55:01Z

[Term]
id: GO:0072194
name: kidney smooth muscle tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of smooth muscle in the kidney over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10]
is_a: GO:0048745 ! smooth muscle tissue development
relationship: part_of GO:0001822 ! kidney development
created_by: midori
creation_date: 2010-03-01T02:05:30Z

[Term]
id: GO:0072195
name: kidney smooth muscle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell in the kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0051145 ! smooth muscle cell differentiation
is_a: GO:0061005 ! cell differentiation involved in kidney development
relationship: part_of GO:0072194 ! kidney smooth muscle tissue development
created_by: midori
creation_date: 2010-03-01T02:07:52Z

[Term]
id: GO:0072196
name: proximal/distal pattern formation involved in pronephric nephron development
namespace: biological_process
def: "The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis of the pronephros." [GOC:mtg_kidney_jan10]
synonym: "pronephros proximal/distal pattern formation" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0039017 ! pattern specification involved in pronephros development
is_a: GO:0072047 ! proximal/distal pattern formation involved in nephron development
intersection_of: GO:0009954 ! proximal/distal pattern formation
intersection_of: part_of GO:0039019 ! pronephric nephron development
relationship: part_of GO:0039019 ! pronephric nephron development
created_by: midori
creation_date: 2010-03-01T02:11:07Z

[Term]
id: GO:0072197
name: ureter morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the ureter are generated and organized. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder." [GOC:mtg_kidney_jan10]
is_a: GO:0009887 ! organ morphogenesis
is_a: GO:0035239 ! tube morphogenesis
relationship: part_of GO:0072189 ! ureter development
created_by: midori
creation_date: 2010-03-01T02:24:55Z

[Term]
id: GO:0072198
name: mesenchymal cell proliferation involved in ureter development
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population of the ureter, that contributes to ureter development." [GOC:mtg_kidney_jan10]
synonym: "ureter mesenchymal cell proliferation" RELATED [GOC:mtg_kidney_jan10]
synonym: "ureteral mesenchymal cell proliferation" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0010463 ! mesenchymal cell proliferation
intersection_of: GO:0010463 ! mesenchymal cell proliferation
intersection_of: part_of GO:0072189 ! ureter development
relationship: part_of GO:0072189 ! ureter development
created_by: midori
creation_date: 2010-03-01T03:24:41Z

[Term]
id: GO:0072199
name: regulation of mesenchymal cell proliferation involved in ureter development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation that contributes to the progression of the ureter gland over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:mtg_kidney_jan10]
synonym: "regulation of ureter mesenchymal cell proliferation" RELATED [GOC:mtg_kidney_jan10]
synonym: "regulation of ureteral mesenchymal cell proliferation" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0010464 ! regulation of mesenchymal cell proliferation
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072198 ! mesenchymal cell proliferation involved in ureter development
relationship: regulates GO:0072198 ! mesenchymal cell proliferation involved in ureter development
created_by: midori
creation_date: 2010-03-01T03:38:13Z

[Term]
id: GO:0072200
name: negative regulation of mesenchymal cell proliferation involved in ureter development
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation that contributes to the progression of the ureter gland over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:mtg_kidney_jan10]
synonym: "negative regulation of ureter mesenchymal cell proliferation" RELATED [GOC:mtg_kidney_jan10]
synonym: "negative regulation of ureteral mesenchymal cell proliferation" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0072199 ! regulation of mesenchymal cell proliferation involved in ureter development
is_a: GO:0072201 ! negative regulation of mesenchymal cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072198 ! mesenchymal cell proliferation involved in ureter development
relationship: negatively_regulates GO:0072198 ! mesenchymal cell proliferation involved in ureter development
created_by: midori
creation_date: 2010-03-01T03:42:31Z

[Term]
id: GO:0072201
name: negative regulation of mesenchymal cell proliferation
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:mtg_kidney_jan10]
is_a: GO:0010464 ! regulation of mesenchymal cell proliferation
is_a: GO:2000647 ! negative regulation of stem cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010463 ! mesenchymal cell proliferation
relationship: negatively_regulates GO:0010463 ! mesenchymal cell proliferation
created_by: midori
creation_date: 2010-03-01T03:43:29Z

[Term]
id: GO:0072202
name: cell differentiation involved in metanephros development
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the metanephros as it progresses from its formation to the mature state." [GOC:mah, GOC:mtg_kidney_jan10]
is_a: GO:0061005 ! cell differentiation involved in kidney development
intersection_of: GO:0030154 ! cell differentiation
intersection_of: part_of GO:0001656 ! metanephros development
relationship: part_of GO:0001656 ! metanephros development
created_by: midori
creation_date: 2010-03-18T10:40:14Z

[Term]
id: GO:0072203
name: cell proliferation involved in metanephros development
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of the population in the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072111 ! cell proliferation involved in kidney development
intersection_of: GO:0008283 ! cell proliferation
intersection_of: part_of GO:0001656 ! metanephros development
relationship: part_of GO:0001656 ! metanephros development
created_by: midori
creation_date: 2010-03-18T10:42:27Z

[Term]
id: GO:0072204
name: cell-cell signaling involved in metanephros development
namespace: biological_process
def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the metanephros over time, from its formation to the mature organ." [GOC:mtg_kidney_jan10]
synonym: "cell-cell signalling involved in metanephros development" EXACT [GOC:mah]
is_a: GO:0060995 ! cell-cell signaling involved in kidney development
intersection_of: GO:0007267 ! cell-cell signaling
intersection_of: part_of GO:0001656 ! metanephros development
relationship: part_of GO:0001656 ! metanephros development
created_by: midori
creation_date: 2010-03-18T10:54:36Z

[Term]
id: GO:0072205
name: metanephric collecting duct development
namespace: biological_process
def: "The process whose specific outcome is the progression of a collecting duct in the metanephros over time, from its formation to the mature structure. The collecting duct responds to vasopressin and aldosterone to regulate water, electrolyte and acid-base balance. The collecting duct is the final common path through which urine flows before entering the ureter and then emptying into the bladder." [GOC:mtg_kidney_jan10]
is_a: GO:0072044 ! collecting duct development
relationship: part_of GO:0001656 ! metanephros development
created_by: midori
creation_date: 2010-03-18T11:15:37Z

[Term]
id: GO:0072206
name: metanephric juxtaglomerular apparatus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the juxtaglomerular apparatus in the metanephros over time, from its formation to the mature structure. The juxtaglomerular apparatus is an anatomical structure which consists of juxtaglomerular cells, extraglomerular mesangial cells and the macula densa. The juxtaglomerular apparatus lies adjacent to the glomerulus and regulates kidney function by maintaining the blood flow to the kidney and the filtration rate." [GOC:mtg_kidney_jan10]
is_a: GO:0072051 ! juxtaglomerular apparatus development
relationship: part_of GO:0001656 ! metanephros development
created_by: midori
creation_date: 2010-03-18T11:17:47Z

[Term]
id: GO:0072207
name: metanephric epithelium development
namespace: biological_process
def: "The process whose specific outcome is the progression of an epithelium in the metanephros over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:mtg_kidney_jan10]
is_a: GO:0072073 ! kidney epithelium development
relationship: part_of GO:0001656 ! metanephros development
created_by: midori
creation_date: 2010-03-18T11:50:37Z

[Term]
id: GO:0072208
name: metanephric smooth muscle tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of smooth muscle in the metanephros over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10]
is_a: GO:0072194 ! kidney smooth muscle tissue development
relationship: part_of GO:0001656 ! metanephros development
created_by: midori
creation_date: 2010-03-18T11:51:59Z

[Term]
id: GO:0072209
name: metanephric mesangial cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesangial cells of the metanephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
is_a: GO:0072007 ! mesangial cell differentiation
is_a: GO:0072202 ! cell differentiation involved in metanephros development
created_by: midori
creation_date: 2010-03-18T11:56:44Z

[Term]
id: GO:0072210
name: metanephric nephron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a nephron in the metanephros over time, from its formation to the mature structure. A nephron is the functional unit of the kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0072006 ! nephron development
relationship: part_of GO:0001656 ! metanephros development
created_by: midori
creation_date: 2010-03-18T12:52:57Z

[Term]
id: GO:0072211
name: metanephric pyramids development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric pyramids over time, from their formation to the mature structures. Metanephric pyramids are the conical masses that constitute the renal medulla in a metanephros; they contain the loops of Henle and the medullary collecting ducts." [GOC:mtg_kidney_jan10]
synonym: "metanephric kidney pyramid development" EXACT [GOC:mah]
synonym: "metanephric pyramid development" EXACT [GOC:mah]
synonym: "metanephric renal medulla development" EXACT [GOC:mah]
synonym: "metanephric renal pyramid development" EXACT [GOC:mah]
is_a: GO:0072056 ! pyramid development
relationship: part_of GO:0001656 ! metanephros development
created_by: midori
creation_date: 2010-03-18T01:04:51Z

[Term]
id: GO:0072212
name: regulation of transcription from RNA polymerase II promoter involved in metanephros development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the branching morphogenesis by which the metanephros progresses from its initial formation to the mature state." [GOC:mtg_kidney_jan10]
is_a: GO:0060994 ! regulation of transcription from RNA polymerase II promoter involved in kidney development
intersection_of: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
intersection_of: part_of GO:0001656 ! metanephros development
relationship: part_of GO:0001656 ! metanephros development
created_by: midori
creation_date: 2010-03-18T01:14:09Z

[Term]
id: GO:0072213
name: metanephric capsule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric capsule over time, from its formation to the mature structure. The metanephric capsule is the tough fibrous layer surrounding the metanephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage." [GOC:mtg_kidney_jan10]
is_a: GO:0072127 ! renal capsule development
relationship: part_of GO:0001656 ! metanephros development
created_by: midori
creation_date: 2010-03-18T01:25:19Z

[Term]
id: GO:0072214
name: metanephric cortex development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric cortex over time, from its formation to the mature structure. The metanephric cortex is the outer region of the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0060485 ! mesenchyme development
is_a: GO:0072055 ! renal cortex development
relationship: part_of GO:0001656 ! metanephros development
created_by: midori
creation_date: 2010-03-18T01:29:49Z

[Term]
id: GO:0072215
name: regulation of metanephros development
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of metanephros development. Metanephros development is the process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:mtg_kidney_jan10]
is_a: GO:0090183 ! regulation of kidney development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001656 ! metanephros development
relationship: regulates GO:0001656 ! metanephros development

[Term]
id: GO:0072216
name: positive regulation of metanephros development
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of metanephros development. Metanephros development is the process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. The metanephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:mtg_kidney_jan10]
is_a: GO:0072215 ! regulation of metanephros development
is_a: GO:0090184 ! positive regulation of kidney development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001656 ! metanephros development
relationship: positively_regulates GO:0001656 ! metanephros development
created_by: midori
creation_date: 2010-03-18T01:40:12Z

[Term]
id: GO:0072217
name: negative regulation of metanephros development
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of metanephros development. Metanephros development is the process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. The metanephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:mtg_kidney_jan10]
is_a: GO:0072215 ! regulation of metanephros development
is_a: GO:0090185 ! negative regulation of kidney development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001656 ! metanephros development
relationship: negatively_regulates GO:0001656 ! metanephros development
created_by: midori
creation_date: 2010-03-18T01:45:48Z

[Term]
id: GO:0072218
name: metanephric ascending thin limb development
namespace: biological_process
def: "The process whose specific outcome is the progression of a metanephric ascending thin limb over time, from its formation to the mature structure. The metanephric ascending thin limb is a segment of a nephron tubule in the metanephros lying in the inner medulla that is permeable to ions but not to water and has a simple epithelium; active transepithelial solute transport is absent." [GOC:mtg_kidney_jan10]
is_a: GO:0072021 ! ascending thin limb development
is_a: GO:0072234 ! metanephric nephron tubule development
relationship: part_of GO:0072236 ! metanephric loop of Henle development
created_by: midori
creation_date: 2010-03-18T03:34:42Z

[Term]
id: GO:0072219
name: metanephric cortical collecting duct development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric cortical collecting duct over time, from its formation to the mature structure. The metanephric cortical collecting duct is the portion of the metanephric collecting duct that resides in the renal cortex." [GOC:mtg_kidney_jan10]
is_a: GO:0072059 ! cortical collecting duct development
created_by: midori
creation_date: 2010-03-18T03:34:52Z

[Term]
id: GO:0072220
name: metanephric descending thin limb development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric descending thin limb over time, from its formation to the mature structure. The metanephric descending thin limb is a part of the metanephric loop of Henle situated just after the proximal straight tubule (S3). It extends to the tip of the metanephric loop of Henle." [GOC:mtg_kidney_jan10]
is_a: GO:0072022 ! descending thin limb development
relationship: part_of GO:0072236 ! metanephric loop of Henle development
created_by: midori
creation_date: 2010-03-18T03:35:05Z

[Term]
id: GO:0072221
name: metanephric distal convoluted tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric distal convoluted tubule over time, from its formation to the mature structure. The metanephric distal convoluted tubule is the first segment of the metanephric nephron lying just downstream from the loop of Henle, immediately after the macula densa. Among other functions, in humans it is responsible for the reabsorption of about 5% of filtered sodium via the thiazide-sensitive Na-Cl symporter." [GOC:mtg_kidney_jan10]
is_a: GO:0072025 ! distal convoluted tubule development
is_a: GO:0072234 ! metanephric nephron tubule development
relationship: part_of GO:0072235 ! metanephric distal tubule development
created_by: midori
creation_date: 2010-03-18T03:35:27Z

[Term]
id: GO:0072222
name: metanephric early distal convoluted tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric early distal convoluted tubule over time, from its formation to the mature structure. The metanephric early distal convoluted tubule contains metanephric DCT cells and is vasopressin-insensitive." [GOC:mtg_kidney_jan10]
is_a: GO:0072067 ! early distal convoluted tubule development
is_a: GO:0072243 ! metanephric nephron epithelium development
relationship: part_of GO:0072221 ! metanephric distal convoluted tubule development
created_by: midori
creation_date: 2010-03-18T03:35:46Z

[Term]
id: GO:0072223
name: metanephric glomerular mesangium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric glomerular mesangium over time, from its formation to the mature structure. The metanephric glomerular mesangium is the thin membrane connective tissue composed of mesangial cells in the metanephros, which helps to support the capillary loops in a renal glomerulus." [GOC:mtg_kidney_jan10]
is_a: GO:0072109 ! glomerular mesangium development
relationship: part_of GO:0072239 ! metanephric glomerulus vasculature development
created_by: midori
creation_date: 2010-03-18T03:35:56Z

[Term]
id: GO:0072224
name: metanephric glomerulus development
namespace: biological_process
def: "The progression of the metanephric glomerulus over time from its initial formation until its mature state. The metanephric glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the mature vertebrate kidney, or metanephros." [GOC:mah]
synonym: "metanephric glomerular development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0032835 ! glomerulus development
relationship: part_of GO:0072210 ! metanephric nephron development
created_by: midori
creation_date: 2010-03-18T03:36:20Z

[Term]
id: GO:0072225
name: metanephric late distal convoluted tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric late distal convoluted tubule over time, from its formation to the mature structure. The metanephric late distal convoluted tubule contains metanephric DCT cells and intercalated (IC) alpha and beta cells and is vasopressin-sensitive." [GOC:mtg_kidney_jan10]
is_a: GO:0072068 ! late distal convoluted tubule development
is_a: GO:0072243 ! metanephric nephron epithelium development
relationship: part_of GO:0072221 ! metanephric distal convoluted tubule development
created_by: midori
creation_date: 2010-03-18T03:37:04Z

[Term]
id: GO:0072226
name: metanephric long descending thin limb bend development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric long descending thin limb bend over time, from its formation to the mature structure. The metanephric long descending thin limb bend is a part of the descending thin limb of a long nephron that lies beyond the prebend segment in the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072065 ! long descending thin limb bend development
relationship: part_of GO:0072220 ! metanephric descending thin limb development
relationship: part_of GO:0072269 ! metanephric long descending thin limb development
created_by: midori
creation_date: 2010-03-18T03:37:16Z

[Term]
id: GO:0072227
name: metanephric macula densa development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric macula densa over time, from its formation to the mature structure. The metanephric macula densa is an area of specialized cells in the distal tubule of the metanephros that makes contact with the vascular pole of the glomerulus." [GOC:mtg_kidney_jan10]
is_a: GO:0072024 ! macula densa development
is_a: GO:0072243 ! metanephric nephron epithelium development
relationship: part_of GO:0072206 ! metanephric juxtaglomerular apparatus development
created_by: midori
creation_date: 2010-03-18T03:37:26Z

[Term]
id: GO:0072228
name: metanephric prebend segment development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric prebend segment over time, from its formation to the mature structure. The metanephric prebend segment is a part of the metanephric descending thin limb that lies before the bend and exhibits permeabilities characteristic of the ascending limb, especially negligible water permeability." [GOC:mtg_kidney_jan10]
is_a: GO:0072066 ! prebend segment development
relationship: part_of GO:0072220 ! metanephric descending thin limb development
created_by: midori
creation_date: 2010-03-18T03:37:46Z

[Term]
id: GO:0072229
name: metanephric proximal convoluted tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric proximal convoluted tubule over time, from its formation to the mature structure. The metanephric proximal convoluted tubule is the most proximal portion of the metanephric proximal tubule and extends from the metanephric glomerular capsule to the metanephric proximal straight tubule." [GOC:mtg_kidney_jan10]
is_a: GO:0072019 ! proximal convoluted tubule development
is_a: GO:0072234 ! metanephric nephron tubule development
relationship: part_of GO:0072237 ! metanephric proximal tubule development
created_by: midori
creation_date: 2010-03-18T03:37:56Z

[Term]
id: GO:0072230
name: metanephric proximal straight tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric proximal straight tubule over time, from its formation to the mature structure. The metanephric proximal straight tubule is the part of the metanephric descending limb that extends from the metanephric proximal convoluted tubule to the metanephric descending thin tubule." [GOC:mtg_kidney_jan10]
synonym: "metanephric S3 development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072020 ! proximal straight tubule development
is_a: GO:0072234 ! metanephric nephron tubule development
relationship: part_of GO:0072237 ! metanephric proximal tubule development
created_by: midori
creation_date: 2010-03-18T03:38:53Z

[Term]
id: GO:0072231
name: metanephric proximal convoluted tubule segment 1 development
namespace: biological_process
def: "The process whose specific outcome is the progression of the S1 portion of the metanephric proximal convoluted tubule over time, from its formation to the mature structure. The S1 portion is the initial portion of the metanephric proximal convoluted tubule and is responsible for avid reabsorption of water and solutes." [GOC:bf, GOC:mtg_kidney_jan10]
synonym: "metanephric S1 development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072031 ! proximal convoluted tubule segment 1 development
relationship: part_of GO:0072229 ! metanephric proximal convoluted tubule development
created_by: midori
creation_date: 2010-03-18T03:39:10Z

[Term]
id: GO:0072232
name: metanephric proximal convoluted tubule segment 2 development
namespace: biological_process
def: "The process whose specific outcome is the progression of the S2 portion of the metanephric proximal convoluted tubule over time, from its formation to the mature structure. The S2 portion of the metanephric proximal tubule is involved in reabsorption of water and sodium chloride." [GOC:bf, GOC:mtg_kidney_jan10]
synonym: "metanephric S2 development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072032 ! proximal convoluted tubule segment 2 development
relationship: part_of GO:0072229 ! metanephric proximal convoluted tubule development
created_by: midori
creation_date: 2010-03-18T03:39:28Z

[Term]
id: GO:0072233
name: metanephric thick ascending limb development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric thick ascending limb over time, from its formation to the mature structure. The metanephric thick ascending limb is the last part of the metanephric loop of Henle. Its thick, mitochondria-rich epithelium characterizes the outer medulla, and is responsible for very avid active salt transport. At the macula densa, the thick ascending limb connects to the distal convoluted tubule." [GOC:mtg_kidney_jan10]
synonym: "metanephric TAL development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072023 ! thick ascending limb development
is_a: GO:0072234 ! metanephric nephron tubule development
relationship: part_of GO:0072235 ! metanephric distal tubule development
created_by: midori
creation_date: 2010-03-18T03:39:36Z

[Term]
id: GO:0072234
name: metanephric nephron tubule development
namespace: biological_process
def: "The progression of a metanephric nephron tubule over time, from its initial formation to the mature structure. A metanephric nephron tubule is an epithelial tube that is part of the metanephric nephron, the functional part of the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072080 ! nephron tubule development
is_a: GO:0072170 ! metanephric tubule development
is_a: GO:0072243 ! metanephric nephron epithelium development
created_by: midori
creation_date: 2010-03-18T03:41:23Z

[Term]
id: GO:0072235
name: metanephric distal tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric distal tubule over time, from its formation to the mature structure. The metanephric distal tubule is a metanephric nephron tubule that begins at the metanephric macula densa and extends to the metanephric connecting tubule." [GOC:mtg_kidney_jan10]
is_a: GO:0072017 ! distal tubule development
is_a: GO:0072234 ! metanephric nephron tubule development
created_by: midori
creation_date: 2010-03-18T03:45:37Z

[Term]
id: GO:0072236
name: metanephric loop of Henle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric loop of Henle over time, from its formation to the mature structure. The metanephric loop of Henle is a metanephric nephron tubule that connects the proximal convoluted tubule to the distal convoluted tubule in the metanephros." [GOC:mtg_kidney_jan10]
synonym: "metanephric intermediate tubule development" EXACT []
is_a: GO:0072070 ! loop of Henle development
is_a: GO:0072234 ! metanephric nephron tubule development
created_by: midori
creation_date: 2010-03-18T03:46:18Z

[Term]
id: GO:0072237
name: metanephric proximal tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric proximal tubule over time, from its formation to the mature structure. The metanephric proximal tubule is a metanephric nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle in the metanephros. It has a brush border epithelial morphology." [GOC:mtg_kidney_jan10]
is_a: GO:0072014 ! proximal tubule development
is_a: GO:0072234 ! metanephric nephron tubule development
created_by: midori
creation_date: 2010-03-18T03:46:54Z

[Term]
id: GO:0072238
name: metanephric long nephron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a metanephric long nephron over time, from its formation to the mature structure. Long nephrons are associated with juxtamedullary glomeruli and extend into the inner medulla in the metanephros." [GOC:mtg_kidney_jan10]
synonym: "metanephric juxtamedullary nephron development" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0072029 ! long nephron development
is_a: GO:0072210 ! metanephric nephron development
created_by: midori
creation_date: 2010-03-18T03:48:23Z

[Term]
id: GO:0072239
name: metanephric glomerulus vasculature development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a metanephric glomerulus vasculature from an initial condition to its mature state. This process begins with the formation of the metanephric glomerulus vasculature and ends with the mature structure. The metanephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the metanephric glomerulus." [GOC:mtg_kidney_jan10]
synonym: "glomerulus capillary development" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0072012 ! glomerulus vasculature development
relationship: part_of GO:0072224 ! metanephric glomerulus development
created_by: midori
creation_date: 2010-03-18T03:50:29Z

[Term]
id: GO:0072240
name: metanephric DCT cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the distal convoluted tubule cells of the metanephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
synonym: "metanephric distal convoluted tubule cell differentiation" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072069 ! DCT cell differentiation
is_a: GO:0072202 ! cell differentiation involved in metanephros development
relationship: part_of GO:0072221 ! metanephric distal convoluted tubule development
created_by: midori
creation_date: 2010-03-19T03:24:25Z

[Term]
id: GO:0072241
name: metanephric DCT cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a metanephric distal convoluted tubule cell over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10]
synonym: "metanephric distal convoluted tubule cell development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072140 ! DCT cell development
relationship: part_of GO:0072240 ! metanephric DCT cell differentiation
created_by: midori
creation_date: 2010-03-19T03:26:44Z

[Term]
id: GO:0072242
name: metanephric DCT cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric distal convoluted tubule cell." [GOC:mtg_kidney_jan10]
synonym: "metanephric distal convoluted tubule cell fate commitment" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072146 ! DCT cell fate commitment
relationship: part_of GO:0072240 ! metanephric DCT cell differentiation
created_by: midori
creation_date: 2010-03-19T03:27:00Z

[Term]
id: GO:0072243
name: metanephric nephron epithelium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric nephron epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The metanephric nephron epithelium is a tissue that covers the surface of a nephron in the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072009 ! nephron epithelium development
is_a: GO:0072207 ! metanephric epithelium development
created_by: midori
creation_date: 2010-03-19T03:29:49Z

[Term]
id: GO:0072244
name: metanephric glomerular epithelium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric glomerular epithelium over time, from its formation to the mature structure. The metanephric glomerular epithelium is an epithelial tissue that covers the outer surfaces of the glomerulus in the metanephros. The metanephric glomerular epithelium consists of both parietal and visceral epithelium. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072010 ! glomerular epithelium development
is_a: GO:0072243 ! metanephric nephron epithelium development
relationship: part_of GO:0072224 ! metanephric glomerulus development
created_by: midori
creation_date: 2010-03-19T03:38:47Z

[Term]
id: GO:0072245
name: metanephric glomerular parietal epithelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a metanephric glomerular parietal epithelial cell. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport." [GOC:mtg_kidney_jan10]
is_a: GO:0072139 ! glomerular parietal epithelial cell differentiation
is_a: GO:0072312 ! metanephric glomerular epithelial cell differentiation
created_by: midori
creation_date: 2010-03-19T03:41:26Z

[Term]
id: GO:0072246
name: metanephric glomerular parietal epithelial cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a metanephric glomerular parietal epithelial cell over time, from its formation to the mature structure. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport." [GOC:mtg_kidney_jan10]
synonym: "metanephric Bowman's capsule development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072016 ! glomerular parietal epithelial cell development
is_a: GO:0072313 ! metanephric glomerular epithelial cell development
relationship: part_of GO:0072245 ! metanephric glomerular parietal epithelial cell differentiation
created_by: midori
creation_date: 2010-03-19T03:42:13Z

[Term]
id: GO:0072247
name: metanephric glomerular parietal epithelial cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric glomerular parietal epithelial cell. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. These cells may also give rise to podocytes." [GOC:mtg_kidney_jan10]
synonym: "metanephric Bowman's capsule cell fate commitment" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072147 ! glomerular parietal epithelial cell fate commitment
is_a: GO:0072315 ! metanephric glomerular epithelial cell fate commitment
relationship: part_of GO:0072245 ! metanephric glomerular parietal epithelial cell differentiation
created_by: midori
creation_date: 2010-03-19T03:42:27Z

[Term]
id: GO:0072248
name: metanephric glomerular visceral epithelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a metanephric glomerular visceral epithelial cell. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the metanephros." [GOC:mtg_kidney_jan10]
synonym: "metanephric podocyte differentiation" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0072112 ! glomerular visceral epithelial cell differentiation
is_a: GO:0072312 ! metanephric glomerular epithelial cell differentiation
created_by: midori
creation_date: 2010-03-19T03:44:57Z

[Term]
id: GO:0072249
name: metanephric glomerular visceral epithelial cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a metanephric glomerular visceral epithelial cell over time, from its formation to the mature structure. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the metanephros." [GOC:mtg_kidney_jan10]
synonym: "metanephric podocyte development" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0072015 ! glomerular visceral epithelial cell development
is_a: GO:0072313 ! metanephric glomerular epithelial cell development
relationship: part_of GO:0072248 ! metanephric glomerular visceral epithelial cell differentiation
created_by: midori
creation_date: 2010-03-19T03:46:26Z

[Term]
id: GO:0072250
name: metanephric glomerular visceral epithelial cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric glomerular visceral epithelial cell. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the metanephros." [GOC:mtg_kidney_jan10]
synonym: "metanephric podocyte cell fate commitment" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0072149 ! glomerular visceral epithelial cell fate commitment
is_a: GO:0072315 ! metanephric glomerular epithelial cell fate commitment
relationship: part_of GO:0072248 ! metanephric glomerular visceral epithelial cell differentiation
created_by: midori
creation_date: 2010-03-19T03:46:41Z

[Term]
id: GO:0072251
name: metanephric juxtaglomerulus cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the juxtaglomerulus cells of the metanephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
is_a: GO:0072052 ! juxtaglomerulus cell differentiation
is_a: GO:0072202 ! cell differentiation involved in metanephros development
relationship: part_of GO:0072206 ! metanephric juxtaglomerular apparatus development
created_by: midori
creation_date: 2010-03-19T03:54:35Z

[Term]
id: GO:0072252
name: metanephric juxtaglomerulus cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a metanephric juxtaglomerulus cell over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10]
is_a: GO:0072142 ! juxtaglomerulus cell development
relationship: part_of GO:0072251 ! metanephric juxtaglomerulus cell differentiation
created_by: midori
creation_date: 2010-03-19T03:55:31Z

[Term]
id: GO:0072253
name: metanephric juxtaglomerulus cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric juxtaglomerulus cell." [GOC:mtg_kidney_jan10]
is_a: GO:0072150 ! juxtaglomerulus cell fate commitment
relationship: part_of GO:0072251 ! metanephric juxtaglomerulus cell differentiation
created_by: midori
creation_date: 2010-03-19T03:55:47Z

[Term]
id: GO:0072254
name: metanephric glomerular mesangial cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the glomerular mesangial cells of the metanephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
is_a: GO:0072008 ! glomerular mesangial cell differentiation
is_a: GO:0072209 ! metanephric mesangial cell differentiation
relationship: part_of GO:0072223 ! metanephric glomerular mesangium development
created_by: midori
creation_date: 2010-03-19T04:04:02Z

[Term]
id: GO:0072255
name: metanephric glomerular mesangial cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a glomerular mesangial cell in the metanephros over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10]
is_a: GO:0072144 ! glomerular mesangial cell development
relationship: part_of GO:0072254 ! metanephric glomerular mesangial cell differentiation
created_by: midori
creation_date: 2010-03-19T04:06:58Z

[Term]
id: GO:0072256
name: metanephric glomerular mesangial cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric glomerular mesangial cell." [GOC:mtg_kidney_jan10]
is_a: GO:0072152 ! glomerular mesangial cell fate commitment
relationship: part_of GO:0072254 ! metanephric glomerular mesangial cell differentiation
created_by: midori
creation_date: 2010-03-19T04:07:10Z

[Term]
id: GO:0072257
name: metanephric nephron tubule epithelial cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the metanephric nephron tubule as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
is_a: GO:0072160 ! nephron tubule epithelial cell differentiation
is_a: GO:0072202 ! cell differentiation involved in metanephros development
relationship: part_of GO:0072234 ! metanephric nephron tubule development
created_by: midori
creation_date: 2010-03-19T04:11:02Z

[Term]
id: GO:0072258
name: metanephric interstitial fibroblast differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the interstitial fibroblasts of the metanephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
synonym: "metanephros interstitial cell differentiation" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072071 ! kidney interstitial fibroblast differentiation
is_a: GO:0072202 ! cell differentiation involved in metanephros development
created_by: midori
creation_date: 2010-03-19T04:17:32Z

[Term]
id: GO:0072259
name: metanephric interstitial fibroblast development
namespace: biological_process
def: "The process whose specific outcome is the progression of a metanephric interstitial fibroblast over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10]
synonym: "metanephros interstitial cell development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072141 ! renal interstitial fibroblast development
relationship: part_of GO:0072258 ! metanephric interstitial fibroblast differentiation
created_by: midori
creation_date: 2010-03-19T04:18:00Z

[Term]
id: GO:0072260
name: metanephric interstitial fibroblast fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric interstitial fibroblast." [GOC:mtg_kidney_jan10]
synonym: "metanephros interstitial cell fate commitment" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072153 ! renal interstitial fibroblast fate commitment
relationship: part_of GO:0072258 ! metanephric interstitial fibroblast differentiation
created_by: midori
creation_date: 2010-03-19T04:18:10Z

[Term]
id: GO:0072261
name: metanephric extraglomerular mesangial cell proliferation involved in metanephros development
namespace: biological_process
def: "The multiplication or reproduction of extraglomerular glomerular mesangium cells in the metanephros by cell division, resulting in the expansion of their population. Extraglomerular mesangial cells (also known as lacis cells, Goormaghtigh cells) are light-staining cells in the kidney found outside the glomerulus, near the vascular pole and macula densa." [GOC:mtg_kidney_jan10]
synonym: "metanephric Goormaghtigh proliferation" RELATED [GOC:mtg_kidney_jan10]
synonym: "metanephric lacis cell proliferation" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0072122 ! extraglomerular mesangial cell proliferation
is_a: GO:0072203 ! cell proliferation involved in metanephros development
relationship: part_of GO:0072210 ! metanephric nephron development
created_by: midori
creation_date: 2010-03-30T02:14:17Z

[Term]
id: GO:0072262
name: metanephric glomerular mesangial cell proliferation involved in metanephros development
namespace: biological_process
def: "The multiplication or reproduction of glomerular mesangial cells in the metanephros, resulting in the expansion of the population." [GOC:mtg_kidney_jan10]
is_a: GO:0072110 ! glomerular mesangial cell proliferation
is_a: GO:0072203 ! cell proliferation involved in metanephros development
relationship: part_of GO:0072223 ! metanephric glomerular mesangium development
created_by: midori
creation_date: 2010-03-30T02:27:27Z

[Term]
id: GO:0072263
name: metanephric intraglomerular mesangial cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of intraglomerular glomerular mesangium cells in the metanephros by cell division, resulting in the expansion of their population. Intraglomerular mesangial cells are specialized pericytes located among the glomerular capillaries within a renal corpuscle of a kidney. They are required for filtration, structural support and phagocytosis." [GOC:mtg_kidney_jan10]
is_a: GO:0072123 ! intraglomerular mesangial cell proliferation
is_a: GO:0072262 ! metanephric glomerular mesangial cell proliferation involved in metanephros development
created_by: midori
creation_date: 2010-03-30T02:27:53Z

[Term]
id: GO:0072264
name: metanephric glomerular endothelium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric glomerular endothelium over time, from its formation to the mature structure. The metanephric glomerular endothelium is an epithelial tissue that covers the internal surfaces of the glomerulus of the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072011 ! glomerular endothelium development
is_a: GO:0072244 ! metanephric glomerular epithelium development
relationship: part_of GO:0072239 ! metanephric glomerulus vasculature development
created_by: midori
creation_date: 2010-03-30T02:42:26Z

[Term]
id: GO:0072265
name: metanephric capsule morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the metanephric capsule are generated and organized. The metanephric capsule is the tough fibrous layer surrounding the metanephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage." [GOC:mtg_kidney_jan10]
is_a: GO:0072128 ! renal capsule morphogenesis
relationship: part_of GO:0072213 ! metanephric capsule development
created_by: midori
creation_date: 2010-03-30T02:54:49Z

[Term]
id: GO:0072266
name: metanephric capsule formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a metanephric capsule from unspecified parts. The metanephric capsule is the tough fibrous layer surrounding the metanephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage." [GOC:mtg_kidney_jan10]
is_a: GO:0072129 ! renal capsule formation
relationship: part_of GO:0072265 ! metanephric capsule morphogenesis
created_by: midori
creation_date: 2010-03-30T02:56:35Z

[Term]
id: GO:0072267
name: metanephric capsule specification
namespace: biological_process
def: "The regionalization process in which the identity of the metanephric capsule is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:mtg_kidney_jan10]
is_a: GO:0072130 ! renal capsule specification
is_a: GO:0072268 ! pattern specification involved in metanephros development
relationship: part_of GO:0072266 ! metanephric capsule formation
created_by: midori
creation_date: 2010-03-30T02:57:36Z

[Term]
id: GO:0072268
name: pattern specification involved in metanephros development
namespace: biological_process
def: "Any developmental process that results in the creation of defined areas or spaces within the metanephros to which cells respond and eventually are instructed to differentiate." [GOC:mtg_kidney_jan10]
synonym: "metanephros pattern formation" RELATED [GOC:mtg_kidney_jan10]
synonym: "metanephros pattern specification" EXACT [GOC:mtg_kidney_jan10]
synonym: "pattern formation involved in metanephros development" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0061004 ! pattern specification involved in kidney development
intersection_of: GO:0007389 ! pattern specification process
intersection_of: part_of GO:0001656 ! metanephros development
relationship: part_of GO:0001656 ! metanephros development
created_by: midori
creation_date: 2010-03-30T03:06:30Z

[Term]
id: GO:0072269
name: metanephric long descending thin limb development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric long descending thin limb over time, from its formation to the mature structure. The metanephric long descending thin limb is the descending thin limb of a long nephron in the metanephros that has a squamous epithelial morphology. The long descending limb starts in the inner stripe of the outer medulla and extends into the inner medulla." [GOC:mtg_kidney_jan10]
is_a: GO:0072064 ! long descending thin limb development
is_a: GO:0072243 ! metanephric nephron epithelium development
relationship: part_of GO:0072238 ! metanephric long nephron development
created_by: midori
creation_date: 2010-03-30T03:12:05Z

[Term]
id: GO:0072270
name: metanephric short nephron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a short nephron in the metanephros over time, from its formation to the mature structure. Short nephrons are associated with mid-cortical and superficial glomeruli, are situated entirely in the outer medulla, and have no thin ascending limb." [GOC:mtg_kidney_jan10]
is_a: GO:0072030 ! short nephron development
is_a: GO:0072210 ! metanephric nephron development
created_by: midori
creation_date: 2010-03-30T03:15:18Z

[Term]
id: GO:0072271
name: metanephric short descending thin limb development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric short descending thin limb over time, from its formation to the mature structure. The metanephric short descending thin limb is the descending thin limb of a short nephron in the metanephros that has a squamous epithelial morphology." [GOC:mtg_kidney_jan10]
is_a: GO:0072063 ! short descending thin limb development
is_a: GO:0072243 ! metanephric nephron epithelium development
relationship: part_of GO:0072270 ! metanephric short nephron development
created_by: midori
creation_date: 2010-03-30T03:16:25Z

[Term]
id: GO:0072272
name: proximal/distal pattern formation involved in metanephric nephron development
namespace: biological_process
def: "The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis of a nephron in the metanephros. The proximal/distal axis is defined by a line that runs from the center of the kidney (proximal end) outward (distal end)." [GOC:mtg_kidney_jan10]
synonym: "proximal-distal pattern formation involved in metanephric nephron development" EXACT [GOC:mtg_kidney_jan10]
synonym: "proximal/distal metanephric nephron patterning" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072047 ! proximal/distal pattern formation involved in nephron development
is_a: GO:0072268 ! pattern specification involved in metanephros development
intersection_of: GO:0009954 ! proximal/distal pattern formation
intersection_of: part_of GO:0072210 ! metanephric nephron development
relationship: part_of GO:0072210 ! metanephric nephron development
created_by: midori
creation_date: 2010-03-30T03:25:37Z

[Term]
id: GO:0072273
name: metanephric nephron morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the metanephric nephron are generated and organized. A metanephric nephron is the functional unit of the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072028 ! nephron morphogenesis
relationship: part_of GO:0003338 ! metanephros morphogenesis
relationship: part_of GO:0072210 ! metanephric nephron development
created_by: midori
creation_date: 2010-03-30T03:33:19Z

[Term]
id: GO:0072274
name: metanephric glomerular basement membrane development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric glomerular basement membrane over time, from its formation to the mature structure. The metanephric glomerular basement membrane is the basal laminal portion of the metanephric glomerulus which performs the actual filtration." [GOC:mtg_kidney_jan10]
is_a: GO:0032836 ! glomerular basement membrane development
relationship: part_of GO:0072224 ! metanephric glomerulus development
created_by: midori
creation_date: 2010-04-01T02:43:51Z

[Term]
id: GO:0072275
name: metanephric glomerulus morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the metanephric glomerulus are generated and organized. The metanephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney, or metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072102 ! glomerulus morphogenesis
relationship: part_of GO:0072224 ! metanephric glomerulus development
created_by: midori
creation_date: 2010-04-01T02:46:58Z

[Term]
id: GO:0072276
name: metanephric glomerulus vasculature morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the metanephric glomerulus vasculature are generated and organized. The metanephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the metanephric glomerulus." [GOC:mtg_kidney_jan10]
is_a: GO:0072103 ! glomerulus vasculature morphogenesis
relationship: part_of GO:0072239 ! metanephric glomerulus vasculature development
relationship: part_of GO:0072275 ! metanephric glomerulus morphogenesis
created_by: midori
creation_date: 2010-04-01T02:47:32Z

[Term]
id: GO:0072277
name: metanephric glomerular capillary formation
namespace: biological_process
def: "The process that gives rise to a metanephric glomerular capillary. This process pertains to the initial formation of a structure from unspecified parts." [GOC:mtg_kidney_jan10]
is_a: GO:0072104 ! glomerular capillary formation
relationship: part_of GO:0072276 ! metanephric glomerulus vasculature morphogenesis
created_by: midori
creation_date: 2010-04-01T02:47:56Z

[Term]
id: GO:0072278
name: metanephric comma-shaped body morphogenesis
namespace: biological_process
def: "The process in which the metanephric comma-shaped body is generated and organized. The metanephric comma-shaped body is the precursor structure to the metanephric S-shaped body that contributes to the morphogenesis of a nephron in the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072049 ! comma-shaped body morphogenesis
relationship: part_of GO:0072273 ! metanephric nephron morphogenesis
created_by: midori
creation_date: 2010-04-01T03:14:42Z

[Term]
id: GO:0072279
name: convergent extension involved in metanephric nephron morphogenesis
namespace: biological_process
def: "The morphogenetic process in which the renal epithelium narrows along one axis and lengthens in a perpendicular axis that contributes to the shaping of a nephron in the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072045 ! convergent extension involved in nephron morphogenesis
intersection_of: GO:0060026 ! convergent extension
intersection_of: part_of GO:0072273 ! metanephric nephron morphogenesis
relationship: part_of GO:0072273 ! metanephric nephron morphogenesis
created_by: midori
creation_date: 2010-04-01T03:16:11Z

[Term]
id: GO:0072280
name: establishment of planar polarity involved in metanephric nephron morphogenesis
namespace: biological_process
def: "Coordinated organization of groups of cells in the plane of an epithelium that contributes to the shaping of a nephron in the metanephros." [GOC:mtg_kidney_jan10]
synonym: "establishment of planar cell polarity involved in metanephric nephron morphogenesis" NARROW [GOC:mtg_kidney_jan10]
is_a: GO:0072046 ! establishment of planar polarity involved in nephron morphogenesis
intersection_of: GO:0001736 ! establishment of planar polarity
intersection_of: part_of GO:0072273 ! metanephric nephron morphogenesis
relationship: part_of GO:0072273 ! metanephric nephron morphogenesis
created_by: midori
creation_date: 2010-04-01T03:17:18Z

[Term]
id: GO:0072281
name: mesenchymal stem cell differentiation involved in metanephric nephron morphogenesis
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal stem cell that contributes to the shaping of a nephronin the metanephros. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [GOC:mtg_kidney_jan10]
is_a: GO:0061208 ! cell differentiation involved in mesonephros development
is_a: GO:0072037 ! mesenchymal stem cell differentiation involved in nephron morphogenesis
is_a: GO:0072202 ! cell differentiation involved in metanephros development
intersection_of: GO:0072497 ! mesenchymal stem cell differentiation
intersection_of: part_of GO:0072273 ! metanephric nephron morphogenesis
relationship: part_of GO:0072273 ! metanephric nephron morphogenesis
created_by: midori
creation_date: 2010-04-01T03:22:06Z

[Term]
id: GO:0072282
name: metanephric nephron tubule morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a metanephric nephron tubule are generated and organized. A metanephric nephron tubule is an epithelial tube that is part of the metanephric nephron, the functional part of the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072078 ! nephron tubule morphogenesis
is_a: GO:0072173 ! metanephric tubule morphogenesis
relationship: part_of GO:0072234 ! metanephric nephron tubule development
relationship: part_of GO:0072273 ! metanephric nephron morphogenesis
created_by: midori
creation_date: 2010-04-01T03:25:11Z

[Term]
id: GO:0072283
name: metanephric renal vesicle morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the metanephric renal vesicle are generated and organized. The renal vesicle is the primordial structure of the metanephric nephron epithelium, and is formed by the condensation of mesenchymal cells." [GOC:mtg_kidney_jan10]
is_a: GO:0072077 ! renal vesicle morphogenesis
relationship: part_of GO:0072273 ! metanephric nephron morphogenesis
created_by: midori
creation_date: 2010-04-01T03:28:00Z

[Term]
id: GO:0072284
name: metanephric S-shaped body morphogenesis
namespace: biological_process
def: "The process in which the metanephric S-shaped body is generated and organized. The metanephric S-shaped body is the successor of the metanephric comma-shaped body that contributes to the morphogenesis of a nephron in the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072050 ! S-shaped body morphogenesis
relationship: part_of GO:0072273 ! metanephric nephron morphogenesis
created_by: midori
creation_date: 2010-04-01T03:41:36Z

[Term]
id: GO:0072285
name: mesenchymal to epithelial transition involved in metanephric renal vesicle formation
namespace: biological_process
def: "A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephric renal vesicle." [GOC:mtg_kidney_jan10]
is_a: GO:0003337 ! mesenchymal to epithelial transition involved in metanephros morphogenesis
is_a: GO:0072036 ! mesenchymal to epithelial transition involved in renal vesicle formation
intersection_of: GO:0060231 ! mesenchymal to epithelial transition
intersection_of: part_of GO:0072093 ! metanephric renal vesicle formation
relationship: part_of GO:0072093 ! metanephric renal vesicle formation
created_by: midori
creation_date: 2010-04-01T03:43:31Z

[Term]
id: GO:0072286
name: metanephric connecting tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric connecting tubule over time, from its formation to the mature structure. The metanephric connecting tubule is a tubular segment of the metanephric nephron; it connects the distal convoluted tubule to the collecting duct in the metanephros." [GOC:mtg_kidney_jan10]
synonym: "metanephric connecting duct development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072027 ! connecting tubule development
is_a: GO:0072234 ! metanephric nephron tubule development
created_by: midori
creation_date: 2010-04-09T03:30:09Z

[Term]
id: GO:0072287
name: metanephric distal tubule morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a metanephric distal tubule are generated and organized. The metanephric distal tubule is a metanephric nephron tubule that begins at the macula densa and extends to the metanephric connecting tubule." [GOC:mtg_kidney_jan10]
is_a: GO:0072156 ! distal tubule morphogenesis
is_a: GO:0072282 ! metanephric nephron tubule morphogenesis
relationship: part_of GO:0072235 ! metanephric distal tubule development
created_by: midori
creation_date: 2010-04-09T03:41:47Z

[Term]
id: GO:0072288
name: metanephric proximal tubule morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a metanephric proximal tubule are generated and organized. The metanephric proximal tubule is a metanephric nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle in the metanephros. It has a brush border epithelial morphology." [GOC:mtg_kidney_jan10]
is_a: GO:0072158 ! proximal tubule morphogenesis
is_a: GO:0072282 ! metanephric nephron tubule morphogenesis
relationship: part_of GO:0072237 ! metanephric proximal tubule development
created_by: midori
creation_date: 2010-04-09T03:42:03Z

[Term]
id: GO:0072289
name: metanephric nephron tubule formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a metanephric nephron tubule from unspecified parts. A metanephric nephron tubule is an epithelial tube that is part of a nephron in the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072079 ! nephron tubule formation
is_a: GO:0072174 ! metanephric tubule formation
relationship: part_of GO:0072282 ! metanephric nephron tubule morphogenesis
created_by: midori
creation_date: 2010-04-09T03:47:44Z

[Term]
id: GO:0072290
name: epithelial cell migration involved in metanephric nephron tubule morphogenesis
namespace: biological_process
def: "The orderly movement of epithelial cells within a renal tubule that contributes to metanephric nephron tubule morphogenesis." [GOC:mtg_kidney_jan10]
is_a: GO:0035788 ! cell migration involved in metanephros development
is_a: GO:0072155 ! epithelial cell migration involved in nephron tubule morphogenesis
intersection_of: GO:0010631 ! epithelial cell migration
intersection_of: part_of GO:0072282 ! metanephric nephron tubule morphogenesis
relationship: part_of GO:0072282 ! metanephric nephron tubule morphogenesis
created_by: midori
creation_date: 2010-04-09T03:52:29Z

[Term]
id: GO:0072291
name: epithelial cell migration involved in metanephric distal tubule morphogenesis
namespace: biological_process
def: "The orderly movement of epithelial cells within a renal tubule that contributes to metanephric distal tubule morphogenesis." [GOC:mtg_kidney_jan10]
is_a: GO:0072157 ! epithelial cell migration involved in distal tubule morphogenesis
is_a: GO:0072290 ! epithelial cell migration involved in metanephric nephron tubule morphogenesis
intersection_of: GO:0010631 ! epithelial cell migration
intersection_of: part_of GO:0072287 ! metanephric distal tubule morphogenesis
relationship: part_of GO:0072287 ! metanephric distal tubule morphogenesis
created_by: midori
creation_date: 2010-04-09T03:53:37Z

[Term]
id: GO:0072292
name: epithelial cell migration involved in metanephric proximal tubule morphogenesis
namespace: biological_process
def: "The orderly movement of epithelial cells within a renal tubule that contributes to metanephric proximal tubule morphogenesis." [GOC:mtg_kidney_jan10]
is_a: GO:0072159 ! epithelial cell migration involved in proximal tubule morphogenesis
is_a: GO:0072290 ! epithelial cell migration involved in metanephric nephron tubule morphogenesis
intersection_of: GO:0010631 ! epithelial cell migration
intersection_of: part_of GO:0072288 ! metanephric proximal tubule morphogenesis
relationship: part_of GO:0072288 ! metanephric proximal tubule morphogenesis
created_by: midori
creation_date: 2010-04-09T03:54:28Z

[Term]
id: GO:0072293
name: specification of metanephric nephron tubule identity
namespace: biological_process
def: "The process in which the tubules arranged along the proximal/distal axis of the metanephric nephron acquire their identity." [GOC:bf, GOC:mtg_kidney_jan10]
is_a: GO:0072081 ! specification of nephron tubule identity
is_a: GO:0072268 ! pattern specification involved in metanephros development
relationship: part_of GO:0072272 ! proximal/distal pattern formation involved in metanephric nephron development
relationship: part_of GO:0072289 ! metanephric nephron tubule formation
created_by: midori
creation_date: 2010-04-09T03:58:10Z

[Term]
id: GO:0072294
name: specification of metanephric connecting tubule identity
namespace: biological_process
def: "The process in which the connecting tubule of the metanephric nephron acquires its identity." [GOC:bf, GOC:mtg_kidney_jan10]
is_a: GO:0072085 ! specification of connecting tubule identity
is_a: GO:0072293 ! specification of metanephric nephron tubule identity
relationship: part_of GO:0072286 ! metanephric connecting tubule development
created_by: midori
creation_date: 2010-04-09T04:00:31Z

[Term]
id: GO:0072295
name: specification of metanephric distal tubule identity
namespace: biological_process
def: "The process in which the distal tubule of the metanephric nephron acquires its identity." [GOC:bf, GOC:mtg_kidney_jan10]
is_a: GO:0072084 ! specification of distal tubule identity
is_a: GO:0072293 ! specification of metanephric nephron tubule identity
relationship: part_of GO:0072287 ! metanephric distal tubule morphogenesis
created_by: midori
creation_date: 2010-04-09T04:01:42Z

[Term]
id: GO:0072296
name: specification of metanephric loop of Henle identity
namespace: biological_process
def: "The process in which the loop of Henle of the metanephric nephron acquires its identity." [GOC:bf, GOC:mtg_kidney_jan10]
synonym: "specification of metanephric intermediate tubule identity" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072086 ! specification of loop of Henle identity
is_a: GO:0072293 ! specification of metanephric nephron tubule identity
relationship: part_of GO:0072236 ! metanephric loop of Henle development
created_by: midori
creation_date: 2010-04-09T04:08:05Z

[Term]
id: GO:0072297
name: specification of metanephric proximal tubule identity
namespace: biological_process
def: "The process in which the proximal tubule of the metanephric nephron acquires its identity." [GOC:bf, GOC:mtg_kidney_jan10]
is_a: GO:0072082 ! specification of proximal tubule identity
is_a: GO:0072293 ! specification of metanephric nephron tubule identity
relationship: part_of GO:0072288 ! metanephric proximal tubule morphogenesis
created_by: midori
creation_date: 2010-04-09T04:08:20Z

[Term]
id: GO:0072298
name: regulation of metanephric glomerulus development
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of metanephric glomerulus development, the progression of the metanephric glomerulus over time from its initial formation until its mature state. The metanephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney, or metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0001656 ! metanephros development
is_a: GO:0072215 ! regulation of metanephros development
is_a: GO:0090192 ! regulation of glomerulus development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072224 ! metanephric glomerulus development
relationship: regulates GO:0072224 ! metanephric glomerulus development
created_by: midori
creation_date: 2010-04-09T05:03:14Z

[Term]
id: GO:0072299
name: negative regulation of metanephric glomerulus development
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of metanephric glomerulus development, the progression of the metanephric glomerulus over time from its initial formation until its mature state. The metanephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney, or metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072217 ! negative regulation of metanephros development
is_a: GO:0072298 ! regulation of metanephric glomerulus development
is_a: GO:0090194 ! negative regulation of glomerulus development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072224 ! metanephric glomerulus development
relationship: negatively_regulates GO:0072224 ! metanephric glomerulus development
created_by: midori
creation_date: 2010-04-09T05:03:41Z

[Term]
id: GO:0072300
name: positive regulation of metanephric glomerulus development
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of metanephric glomerulus development, the progression of the metanephric glomerulus over time from its initial formation until its mature state. The metanephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney, or metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072216 ! positive regulation of metanephros development
is_a: GO:0072298 ! regulation of metanephric glomerulus development
is_a: GO:0090193 ! positive regulation of glomerulus development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072224 ! metanephric glomerulus development
relationship: positively_regulates GO:0072224 ! metanephric glomerulus development
created_by: midori
creation_date: 2010-04-09T05:03:41Z

[Term]
id: GO:0072301
name: regulation of metanephric glomerular mesangial cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of metanephric glomerular mesangial cell proliferation." [GOC:mtg_kidney_jan10]
is_a: GO:0072124 ! regulation of glomerular mesangial cell proliferation
is_a: GO:0072298 ! regulation of metanephric glomerulus development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072262 ! metanephric glomerular mesangial cell proliferation involved in metanephros development
relationship: regulates GO:0072262 ! metanephric glomerular mesangial cell proliferation involved in metanephros development
created_by: midori
creation_date: 2010-04-09T05:03:41Z

[Term]
id: GO:0072302
name: negative regulation of metanephric glomerular mesangial cell proliferation
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of metanephric glomerular mesangial cell proliferation." [GOC:mtg_kidney_jan10]
is_a: GO:0072125 ! negative regulation of glomerular mesangial cell proliferation
is_a: GO:0072299 ! negative regulation of metanephric glomerulus development
is_a: GO:0072301 ! regulation of metanephric glomerular mesangial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072262 ! metanephric glomerular mesangial cell proliferation involved in metanephros development
relationship: negatively_regulates GO:0072262 ! metanephric glomerular mesangial cell proliferation involved in metanephros development
created_by: midori
creation_date: 2010-04-09T05:03:41Z

[Term]
id: GO:0072303
name: positive regulation of glomerular metanephric mesangial cell proliferation
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of metanephric glomerular mesangial cell proliferation." [GOC:mtg_kidney_jan10]
is_a: GO:0072126 ! positive regulation of glomerular mesangial cell proliferation
is_a: GO:0072300 ! positive regulation of metanephric glomerulus development
is_a: GO:0072301 ! regulation of metanephric glomerular mesangial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072262 ! metanephric glomerular mesangial cell proliferation involved in metanephros development
relationship: positively_regulates GO:0072262 ! metanephric glomerular mesangial cell proliferation involved in metanephros development
created_by: midori
creation_date: 2010-04-09T05:03:41Z

[Term]
id: GO:0072304
name: regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis
namespace: biological_process
def: "Any process that modulates the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the metanephros." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10]
synonym: "regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis" NARROW []
synonym: "regulation of mesenchymal stem cell apoptotic process involved in metanephric nephron morphogenesis" EXACT []
is_a: GO:0072039 ! regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis
is_a: GO:1900211 ! regulation of mesenchymal cell apoptotic process involved in metanephros development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1901147 ! mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis
relationship: regulates GO:0072309 ! mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis
relationship: regulates GO:1901147 ! mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis
created_by: midori
creation_date: 2010-04-09T05:03:41Z

[Term]
id: GO:0072305
name: negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis
namespace: biological_process
def: "Any process that reduces the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the metanephros." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10]
synonym: "negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis" NARROW []
synonym: "negative regulation of mesenchymal stem cell apoptotic process involved in metanephric nephron morphogenesis" EXACT []
is_a: GO:0072040 ! negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis
is_a: GO:0072304 ! regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis
is_a: GO:1900212 ! negative regulation of mesenchymal cell apoptotic process involved in metanephros development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1901147 ! mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis
relationship: negatively_regulates GO:0072309 ! mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis
relationship: negatively_regulates GO:1901147 ! mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis
created_by: midori
creation_date: 2010-04-09T05:03:41Z

[Term]
id: GO:0072306
name: positive regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis
namespace: biological_process
def: "Any process that increases the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the metanephros." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10]
synonym: "positive regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis" NARROW []
synonym: "positive regulation of mesenchymal stem cell apoptotic process involved in metanephric nephron morphogenesis" EXACT []
is_a: GO:0072041 ! positive regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis
is_a: GO:0072304 ! regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis
is_a: GO:1900213 ! positive regulation of mesenchymal cell apoptotic process involved in metanephros development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1901147 ! mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis
relationship: positively_regulates GO:0072309 ! mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis
relationship: positively_regulates GO:1901147 ! mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis
created_by: midori
creation_date: 2010-04-09T05:03:41Z

[Term]
id: GO:0072307
name: regulation of metanephric nephron tubule epithelial cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of metanephric nephron tubule epithelial cell differentiation." [GOC:mtg_kidney_jan10]
is_a: GO:0072182 ! regulation of nephron tubule epithelial cell differentiation
is_a: GO:0072215 ! regulation of metanephros development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072257 ! metanephric nephron tubule epithelial cell differentiation
relationship: regulates GO:0072257 ! metanephric nephron tubule epithelial cell differentiation
created_by: midori
creation_date: 2010-04-09T05:03:41Z

[Term]
id: GO:0072308
name: negative regulation of metanephric nephron tubule epithelial cell differentiation
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of metanephric nephron tubule epithelial cell differentiation." [GOC:mtg_kidney_jan10]
is_a: GO:0072183 ! negative regulation of nephron tubule epithelial cell differentiation
is_a: GO:0072217 ! negative regulation of metanephros development
is_a: GO:0072307 ! regulation of metanephric nephron tubule epithelial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072257 ! metanephric nephron tubule epithelial cell differentiation
relationship: negatively_regulates GO:0072257 ! metanephric nephron tubule epithelial cell differentiation
created_by: midori
creation_date: 2010-04-09T05:03:41Z

[Term]
id: GO:0072309
name: mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis
namespace: biological_process
def: "The process in which an organism retains a population of mesenchymal stem cells that contributes to the shaping of a nephron in the metanephros. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [GOC:mtg_kidney_jan10]
is_a: GO:0072038 ! mesenchymal stem cell maintenance involved in nephron morphogenesis
relationship: part_of GO:0072273 ! metanephric nephron morphogenesis
created_by: midori
creation_date: 2010-04-09T05:03:41Z

[Term]
id: GO:0072310
name: glomerular epithelial cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a glomerular epithelial cell over time, from its formation to the mature structure. Glomerular epithelial cells are specialized epithelial cells that form part of the glomerulus; there are two types, glomerular parietal epithelial cells and glomerular visceral epithelial cells." [GOC:mtg_kidney_jan10]
is_a: GO:0002064 ! epithelial cell development
relationship: part_of GO:0072311 ! glomerular epithelial cell differentiation
created_by: midori
creation_date: 2010-04-09T06:47:31Z

[Term]
id: GO:0072311
name: glomerular epithelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a glomerular epithelial cell. Glomerular epithelial cells are specialized epithelial cells that form part of the glomerulus; there are two types, glomerular parietal epithelial cells and glomerular visceral epithelial cells." [GOC:mtg_kidney_jan10]
is_a: GO:0035850 ! epithelial cell differentiation involved in kidney development
relationship: part_of GO:0072010 ! glomerular epithelium development
created_by: midori
creation_date: 2010-04-09T06:49:21Z

[Term]
id: GO:0072312
name: metanephric glomerular epithelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a metanephric glomerular epithelial cell. Metanephric glomerular epithelial cells are specialized epithelial cells that form part of the metanephric glomerulus; there are two types, metanephric glomerular parietal epithelial cells and metanephric glomerular visceral epithelial cells." [GOC:mtg_kidney_jan10]
is_a: GO:0072202 ! cell differentiation involved in metanephros development
is_a: GO:0072311 ! glomerular epithelial cell differentiation
relationship: part_of GO:0072244 ! metanephric glomerular epithelium development
created_by: midori
creation_date: 2010-04-09T06:54:15Z

[Term]
id: GO:0072313
name: metanephric glomerular epithelial cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a metanephric glomerular epithelial cell over time, from its formation to the mature structure. Metanephric glomerular epithelial cells are specialized epithelial cells that form part of the metanephric glomerulus; there are two types, metanephric glomerular parietal epithelial cells and metanephric glomerular visceral epithelial cells." [GOC:mtg_kidney_jan10]
is_a: GO:0072310 ! glomerular epithelial cell development
relationship: part_of GO:0072312 ! metanephric glomerular epithelial cell differentiation
created_by: midori
creation_date: 2010-04-09T06:57:26Z

[Term]
id: GO:0072314
name: glomerular epithelial cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a glomerular epithelial cell. Glomerular epithelial cells are specialized epithelial cells that form part of the glomerulus; there are two types, glomerular parietal epithelial cells and glomerular visceral epithelial cells." [GOC:mtg_kidney_jan10]
is_a: GO:0002064 ! epithelial cell development
relationship: part_of GO:0072311 ! glomerular epithelial cell differentiation
created_by: midori
creation_date: 2010-04-09T07:02:25Z

[Term]
id: GO:0072315
name: metanephric glomerular epithelial cell fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric glomerular epithelial cell. Metanephric glomerular epithelial cells are specialized epithelial cells that form part of the metanephric glomerulus; there are two types, metanephric glomerular parietal epithelial cells and metanephric glomerular visceral epithelial cells." [GOC:mtg_kidney_jan10]
is_a: GO:0072314 ! glomerular epithelial cell fate commitment
created_by: midori
creation_date: 2010-04-09T07:03:50Z

[Term]
id: GO:0072316
name: alpha-glucan catabolic process involved in ascospore release from ascus
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of alpha-glucans in the ascus wall that contributes to the release of ascospores from the ascus." [GOC:mah]
subset: gosubset_prok
synonym: "alpha-glucan breakdown involved in ascospore release from ascus" EXACT [GOC:mah]
synonym: "alpha-glucan catabolism involved in ascospore release from ascus" EXACT [GOC:mah]
synonym: "alpha-glucan degradation involved in ascospore release from ascus" EXACT [GOC:mah]
is_a: GO:0030980 ! alpha-glucan catabolic process
is_a: GO:0072000 ! extracellular polysaccharide catabolic process involved in ascospore release from ascus
intersection_of: GO:0030980 ! alpha-glucan catabolic process
intersection_of: part_of GO:0071998 ! ascospore release from ascus
relationship: part_of GO:0071998 ! ascospore release from ascus
created_by: midori
creation_date: 2010-10-25T05:43:52Z

[Term]
id: GO:0072317
name: glucan endo-1,3-beta-D-glucosidase activity involved in ascospore release from ascus
namespace: molecular_function
def: "Catalysis of the hydrolysis of 1,3-beta-D-glucosidic linkages in 1,3-beta-D-glucans that contributes to the release of ascospores from the ascus." [GOC:jl]
subset: gosubset_prok
is_a: GO:0042973 ! glucan endo-1,3-beta-D-glucosidase activity
intersection_of: GO:0042973 ! glucan endo-1,3-beta-D-glucosidase activity
intersection_of: part_of GO:0071998 ! ascospore release from ascus
relationship: part_of GO:0006076 ! (1->3)-beta-D-glucan catabolic process
relationship: part_of GO:0071998 ! ascospore release from ascus
relationship: part_of GO:0072000 ! extracellular polysaccharide catabolic process involved in ascospore release from ascus
created_by: midori
creation_date: 2010-10-25T05:46:13Z

[Term]
id: GO:0072318
name: clathrin coat disassembly
namespace: biological_process
def: "The disaggregation of a clathrin coat into its constituent components; results in stripping or removing the clathrin coat from clathrin-coated vesicles (CCV) before fusing with their targets. CVVs transport cargo from plasma membrane and trans-Golgi to the endosomal system." [PMID:11084334, PMID:11146663, PMID:8524399]
synonym: "clathrin-coat disassembly" EXACT [GOC:rb]
synonym: "clathrin-coat uncoating" EXACT [GOC:rb]
synonym: "clathrin-coated vesicle uncoating" EXACT [GOC:mah]
is_a: GO:0072319 ! vesicle uncoating
created_by: midori
creation_date: 2010-10-26T12:03:37Z

[Term]
id: GO:0072319
name: vesicle uncoating
namespace: biological_process
def: "A protein depolymerization process that results in the disassembly of vesicle coat proteins." [GOC:mah]
synonym: "vesicle coat disassembly" EXACT [GOC:mah]
is_a: GO:0051261 ! protein depolymerization
relationship: part_of GO:0016192 ! vesicle-mediated transport
created_by: midori
creation_date: 2010-10-26T12:09:21Z

[Term]
id: GO:0072320
name: volume-sensitive chloride channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a chloride ion by a volume-sensitive channel. A volume-sensitive channel is a channel that responds to changes in the volume of a cell." [GOC:mah]
synonym: "swell-activated chloride channel" RELATED [GOC:sart, PMID:23056495]
is_a: GO:0005225 ! volume-sensitive anion channel activity
is_a: GO:0005254 ! chloride channel activity
created_by: midori
creation_date: 2010-10-26T12:53:38Z

[Term]
id: GO:0072321
name: chaperone-mediated protein transport
namespace: biological_process
def: "The directed movement of proteins into, out of or within a cell, or between cells, mediated by chaperone molecules that bind to the transported proteins." [GOC:mah, PMID:20378773]
is_a: GO:0015031 ! protein transport
is_a: GO:0044765 ! single-organism transport
created_by: midori
creation_date: 2010-10-28T04:23:20Z

[Term]
id: GO:0072322
name: protein transport across periplasmic space
namespace: biological_process
def: "The directed movement of proteins from the plasma membrane across the periplasmic space to the outer membrane or cell wall." [GOC:mah]
is_a: GO:0015031 ! protein transport
is_a: GO:0044765 ! single-organism transport
created_by: midori
creation_date: 2010-10-28T04:24:59Z

[Term]
id: GO:0072323
name: chaperone-mediated protein transport across periplasmic space
namespace: biological_process
def: "The directed movement of proteins from the plasma membrane across the periplasmic space to the outer membrane, mediated by chaperone molecules that bind to the transported proteins. This process has been observed in Gram-negative bacteria." [GOC:mah, PMID:20378773]
is_a: GO:0072321 ! chaperone-mediated protein transport
is_a: GO:0072322 ! protein transport across periplasmic space
created_by: midori
creation_date: 2010-10-28T04:26:53Z

[Term]
id: GO:0072324
name: ascus epiplasm
namespace: cellular_component
def: "Ascus cytoplasm that is not packaged into ascospores." [DOI:10.1016/S0953-7562(96)80057-8, GOC:mcc]
comment: Note that this term is an is_a child of 'cell part' because the epiplasm is extracellular to the spore (each of which is a cell) but within the ascus structure, and originated from cytoplasm.
is_a: GO:0044464 ! cell part
created_by: midori
creation_date: 2010-10-28T04:37:46Z

[Term]
id: GO:0072325
name: vulval cell fate commitment
namespace: biological_process
def: "The process in which the cellular identity of nematode vulval cells is acquired and determined. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed adult vulva, which is the egg-laying organ of female and hermaphrodite nematodes." [GOC:kmv, GOC:mah, ISBN:087969307X, PMID:11236714]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0040025 ! vulval development
created_by: midori
creation_date: 2010-11-01T02:02:16Z

[Term]
id: GO:0072326
name: vulval cell fate determination
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a nematode vulval cell regardless of its environment; upon determination, the cell fate cannot be reversed. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed adult vulva, which is the egg-laying organ of female and hermaphrodite nematodes." [GOC:kmv, GOC:mah, ISBN:087969307X, PMID:11236714]
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0072325 ! vulval cell fate commitment
created_by: midori
creation_date: 2010-11-01T02:04:46Z

[Term]
id: GO:0072327
name: vulval cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a nematode vulval cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed adult vulva, which is the egg-laying organ of female and hermaphrodite nematodes." [GOC:kmv, GOC:mah, ISBN:087969307X, PMID:11236714]
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0072325 ! vulval cell fate commitment
created_by: midori
creation_date: 2010-11-01T02:14:06Z

[Term]
id: GO:0072328
name: alkene binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an alkene, any acyclic branched or unbranched hydrocarbon having one carbon-carbon double bond and the general formula CnH2n." [CHEBI:32878, GOC:mah]
is_a: GO:0005488 ! binding
created_by: midori
creation_date: 2010-11-02T12:39:40Z

[Term]
id: GO:0072329
name: monocarboxylic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group." [CHEBI:25384, GOC:mah]
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process
created_by: midori
creation_date: 2010-11-02T04:41:55Z

[Term]
id: GO:0072330
name: monocarboxylic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group." [CHEBI:25384, GOC:mah]
synonym: "monocarboxylic acid anabolism" EXACT [GOC:mah]
synonym: "monocarboxylic acid biosynthesis" EXACT [GOC:mah]
synonym: "monocarboxylic acid formation" EXACT [GOC:mah]
synonym: "monocarboxylic acid synthesis" EXACT [GOC:mah]
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
created_by: midori
creation_date: 2010-11-02T04:51:32Z

[Term]
id: GO:0072331
name: signal transduction by p53 class mediator
namespace: biological_process
def: "An intracellular signaling process that is induced by the cell cycle regulator phosphoprotein p53 or an equivalent protein." [GOC:mah]
is_a: GO:0035556 ! intracellular signal transduction
created_by: midori
creation_date: 2010-11-03T01:32:59Z

[Term]
id: GO:0072332
name: intrinsic apoptotic signaling pathway by p53 class mediator
namespace: biological_process
def: "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, and ends when the execution phase of apoptosis is triggered." [GOC:mah, GOC:mtg_apoptosis]
synonym: "intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator" EXACT []
synonym: "signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED []
is_a: GO:0072331 ! signal transduction by p53 class mediator
is_a: GO:0097193 ! intrinsic apoptotic signaling pathway
created_by: midori
creation_date: 2010-11-03T01:47:56Z

[Term]
id: GO:0072333
name: obsolete anoikis by p53 class mediator
namespace: biological_process
def: "OBSOLETE. A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, that results in the induction of anoikis." [GOC:BHF, GOC:mah, GOC:mtg_apoptosis]
comment: This term was made obsolete because it is misleading, since anoikis occurs following detachment of cells from each other and/or from the culture surface; it is not p53 that induces such separation.
synonym: "anoikis by p53 class mediator" EXACT []
synonym: "anoikis by signal transduction by p53 class mediator" EXACT []
synonym: "signal transduction by p53 class mediator resulting in induction of anoikis" RELATED []
is_obsolete: true
created_by: midori
creation_date: 2010-11-03T01:52:56Z

[Term]
id: GO:0072334
name: UDP-galactose transmembrane transport
namespace: biological_process
def: "The directed movement of UDP-galactose across a membrane into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "UDP-galactose membrane transport" EXACT []
is_a: GO:0015785 ! UDP-galactose transport
is_a: GO:0034219 ! carbohydrate transmembrane transport
is_a: GO:0090481 ! pyrimidine nucleotide-sugar transmembrane transport
is_a: GO:0098656 ! anion transmembrane transport
created_by: midori
creation_date: 2010-11-03T02:03:36Z

[Term]
id: GO:0072335
name: regulation of canonical Wnt signaling pathway involved in neural crest cell differentiation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin involved in neural crest cell differentiation. The Wnt signaling pathway is the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dgh]
synonym: "regulation of canonical Wnt receptor signaling pathway involved in neural crest cell differentiation" EXACT []
synonym: "regulation of canonical Wnt receptor signalling pathway involved in neural crest cell differentiation" EXACT [GOC:mah]
synonym: "regulation of canonical Wnt-activated signaling pathway involved in neural crest cell differentiation" EXACT [GOC:signaling]
synonym: "regulation of Wnt receptor signaling pathway through beta-catenin involved in neural crest cell differentiation" EXACT [GOC:mah]
is_a: GO:0060828 ! regulation of canonical Wnt signaling pathway
is_a: GO:2000026 ! regulation of multicellular organismal development
is_a: GO:2000736 ! regulation of stem cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044335 ! canonical Wnt signaling pathway involved in neural crest cell differentiation
relationship: regulates GO:0044335 ! canonical Wnt signaling pathway involved in neural crest cell differentiation
created_by: midori
creation_date: 2010-11-03T03:12:38Z

[Term]
id: GO:0072336
name: negative regulation of canonical Wnt signaling pathway involved in neural crest cell differentiation
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin involved in neural crest cell differentiation. The Wnt signaling pathway is the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dgh]
synonym: "negative regulation of canonical Wnt receptor signaling pathway involved in neural crest cell differentiation" EXACT []
synonym: "negative regulation of canonical Wnt receptor signalling pathway involved in neural crest cell differentiation" EXACT [GOC:mah]
synonym: "negative regulation of canonical Wnt-activated signaling pathway involved in neural crest cell differentiation" RELATED []
synonym: "negative regulation of Wnt receptor signaling pathway through beta-catenin involved in neural crest cell differentiation" EXACT [GOC:mah]
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0072335 ! regulation of canonical Wnt signaling pathway involved in neural crest cell differentiation
is_a: GO:0090090 ! negative regulation of canonical Wnt signaling pathway
is_a: GO:2000737 ! negative regulation of stem cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044335 ! canonical Wnt signaling pathway involved in neural crest cell differentiation
relationship: negatively_regulates GO:0044335 ! canonical Wnt signaling pathway involved in neural crest cell differentiation
created_by: midori
creation_date: 2010-11-03T03:16:10Z

[Term]
id: GO:0072337
name: modified amino acid transport
namespace: biological_process
def: "The directed movement of modified amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:83821, GOC:mah]
synonym: "amino acid derivative transport" EXACT []
is_a: GO:0071702 ! organic substance transport
is_a: GO:0071705 ! nitrogen compound transport
created_by: midori
creation_date: 2010-11-04T12:18:23Z

[Term]
id: GO:0072338
name: cellular lactam metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lactams, any cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring." [CHEBI:24995, GOC:mah]
subset: gosubset_prok
synonym: "cellular lactam metabolism" EXACT [GOC:mah]
is_a: GO:0043603 ! cellular amide metabolic process
is_a: GO:0044281 ! small molecule metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0046483 ! heterocycle metabolic process
created_by: midori
creation_date: 2010-11-04T04:31:21Z

[Term]
id: GO:0072339
name: cellular lactam biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lactams, any cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring." [CHEBI:24995, GOC:mah]
subset: gosubset_prok
synonym: "cellular lactam anabolism" EXACT [GOC:mah]
synonym: "cellular lactam biosynthesis" EXACT [GOC:mah]
synonym: "cellular lactam formation" EXACT [GOC:mah]
synonym: "cellular lactam synthesis" EXACT [GOC:mah]
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:0072338 ! cellular lactam metabolic process
created_by: midori
creation_date: 2010-11-04T04:33:01Z

[Term]
id: GO:0072340
name: cellular lactam catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lactams, any cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring." [CHEBI:24995, GOC:mah]
subset: gosubset_prok
synonym: "cellular lactam breakdown" EXACT [GOC:mah]
synonym: "cellular lactam catabolism" EXACT [GOC:mah]
synonym: "cellular lactam degradation" EXACT [GOC:mah]
is_a: GO:0043605 ! cellular amide catabolic process
is_a: GO:0044712 ! single-organism catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:0072338 ! cellular lactam metabolic process
created_by: midori
creation_date: 2010-11-04T04:33:22Z

[Term]
id: GO:0072341
name: modified amino acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a modified amino acid." [CHEBI:83821, GOC:mah]
synonym: "amino acid derivative binding" EXACT []
is_a: GO:0005488 ! binding
created_by: midori
creation_date: 2010-11-04T05:45:32Z

[Term]
id: GO:0072342
name: response to anion stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of anion stress, an increase or decrease in the concentration of negatively charged ions in the environment." [GOC:cvs, PMID:19641131]
is_a: GO:0009651 ! response to salt stress
created_by: midori
creation_date: 2010-11-05T02:25:28Z

[Term]
id: GO:0072343
name: pancreatic stellate cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of pancreatic stellate cells, resulting in the expansion of a pancreatic stellate cell population. Pancreatic stellate cells are found in the periacinar space of the exocrine pancreas and in perivascular and periductal regions of the pancreas, and have long cytoplasmic processes that encircle the base of the acinus." [CL:0002410, GOC:mah, PMID:17200706]
is_a: GO:0048144 ! fibroblast proliferation
created_by: midori
creation_date: 2010-11-05T03:04:50Z

[Term]
id: GO:0072344
name: rescue of stalled ribosome
namespace: biological_process
def: "A process of translational elongation that takes place when a ribosome has stalled during translation, and results in freeing the ribosome from the stalled translation complex." [GOC:jh2, GOC:mah, PMID:18557701, PMID:19170872, PMID:20117091, PMID:20185543]
subset: gosubset_prok
is_a: GO:0006414 ! translational elongation
is_a: GO:0006417 ! regulation of translation
created_by: midori
creation_date: 2010-11-10T11:54:26Z

[Term]
id: GO:0072345
name: NAADP-sensitive calcium-release channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a calcium ion by a channel that opens when nicotinic acid adenine dinucleotide phosphate (NAADP) has been bound by the channel complex or one of its constituent parts." [PMID:19387438, PMID:19557428]
is_a: GO:0015278 ! calcium-release channel activity
created_by: midori
creation_date: 2010-11-10T01:03:35Z

[Term]
id: GO:0072346
name: cADPR-sensitive calcium-release channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a calcium ion by a channel that opens when cyclic adenosine diphosphate ribose (cADPR) has been bound by the channel complex or one of its constituent parts." [PMID:11752598]
is_a: GO:0015278 ! calcium-release channel activity
created_by: midori
creation_date: 2010-11-10T01:10:51Z

[Term]
id: GO:0072347
name: response to anesthetic
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anesthetic stimulus. An anesthetic is a substance that causes loss of feeling, awareness, or sensation." [CHEBI:38867, GOC:sart]
synonym: "response to anaesthetic" EXACT [GOC:mah]
is_a: GO:0042493 ! response to drug
created_by: midori
creation_date: 2010-11-10T01:26:18Z

[Term]
id: GO:0072348
name: sulfur compound transport
namespace: biological_process
def: "The directed movement of compounds that contain sulfur, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "sulfur-containing compound transport" EXACT [GOC:mah]
is_a: GO:0044765 ! single-organism transport
created_by: midori
creation_date: 2010-11-11T11:43:56Z

[Term]
id: GO:0072349
name: modified amino acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of modified amino acids from one side of a membrane to the other." [CHEBI:83821, GOC:mah]
subset: gosubset_prok
synonym: "amino acid derivative transmembrane transporter activity" EXACT []
synonym: "modified amino acid transporter activity" BROAD [GOC:mah]
is_a: GO:0022857 ! transmembrane transporter activity
relationship: part_of GO:0072337 ! modified amino acid transport
created_by: midori
creation_date: 2010-11-11T11:50:31Z

[Term]
id: GO:0072350
name: tricarboxylic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing three carboxyl (COOH) groups or anions (COO-)." [CHEBI:27093, GOC:mah]
subset: gosubset_prok
synonym: "tricarboxylic acid metabolism" EXACT [GOC:mah]
is_a: GO:0019752 ! carboxylic acid metabolic process
created_by: midori
creation_date: 2010-11-11T05:07:30Z

[Term]
id: GO:0072351
name: tricarboxylic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dicarboxylic acids, any organic acid containing three carboxyl (-COOH) groups." [CHEBI:27093, GOC:mah]
subset: gosubset_prok
synonym: "tricarboxylate biosynthesis" EXACT [GOC:mah]
synonym: "tricarboxylate biosynthetic process" EXACT [GOC:mah]
synonym: "tricarboxylic acid anabolism" EXACT [GOC:mah]
synonym: "tricarboxylic acid biosynthesis" EXACT [GOC:mah]
synonym: "tricarboxylic acid formation" EXACT [GOC:mah]
synonym: "tricarboxylic acid synthesis" EXACT [GOC:mah]
is_a: GO:0046394 ! carboxylic acid biosynthetic process
is_a: GO:0072350 ! tricarboxylic acid metabolic process
created_by: midori
creation_date: 2010-11-11T05:08:54Z

[Term]
id: GO:0072352
name: tricarboxylic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dicarboxylic acids, any organic acid containing three carboxyl (-COOH) groups." [CHEBI:27093, GOC:mah]
subset: gosubset_prok
synonym: "tricarboxylate catabolic process" EXACT [GOC:mah]
synonym: "tricarboxylate catabolism" EXACT [GOC:mah]
synonym: "tricarboxylic acid breakdown" EXACT [GOC:mah]
synonym: "tricarboxylic acid catabolism" EXACT [GOC:mah]
synonym: "tricarboxylic acid degradation" EXACT [GOC:mah]
is_a: GO:0046395 ! carboxylic acid catabolic process
is_a: GO:0072350 ! tricarboxylic acid metabolic process
created_by: midori
creation_date: 2010-11-11T05:11:24Z

[Term]
id: GO:0072353
name: cellular age-dependent response to reactive oxygen species
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of reactive oxygen species, where the change varies according to the age of the cell or organism." [GOC:mah]
is_a: GO:0001315 ! age-dependent response to reactive oxygen species
is_a: GO:0034614 ! cellular response to reactive oxygen species
created_by: midori
creation_date: 2010-11-12T11:27:27Z

[Term]
id: GO:0072354
name: histone kinase activity (H3-T3 specific)
namespace: molecular_function
def: "Catalysis of the transfer of a phosphate group to the threonine-3 residue of the N-terminal tail of histone H3." [GOC:mah]
synonym: "histone threonine kinase activity (H3-T3 specific)" EXACT [GOC:mah]
synonym: "histone-threonine kinase activity (H3-T3 specific)" EXACT [GOC:mah]
is_a: GO:0035184 ! histone threonine kinase activity
relationship: part_of GO:0072355 ! histone H3-T3 phosphorylation
created_by: midori
creation_date: 2010-11-12T04:27:57Z

[Term]
id: GO:0072355
name: histone H3-T3 phosphorylation
namespace: biological_process
def: "The modification of histone H3 by the addition of an phosphate group to a threonine residue at position 3 of the histone." [GOC:mah]
is_a: GO:0035405 ! histone-threonine phosphorylation
created_by: midori
creation_date: 2010-11-12T04:28:56Z

[Term]
id: GO:0072356
name: chromosome passenger complex localization to kinetochore
namespace: biological_process
def: "A cellular protein complex localization that acts on a chromosome passenger complex; as a result, the complex is transported to, or maintained in, a specific location at the kinetochore. A chromosome passenger complex is a protein complex that contains the BIR-domain-containing protein Survivin, Aurora B kinase, INCENP and Borealin, and coordinates various events based on its location to different structures during the course of mitosis." [GOC:mah]
synonym: "chromosomal passenger complex localization to kinetochore" EXACT [GOC:mah]
synonym: "chromosome passenger complex localisation to kinetochore" RELATED [GOC:mah]
synonym: "CPC complex localization to kinetochore" EXACT [GOC:vw]
synonym: "CPC localization to kinetochore" EXACT [GOC:mah]
is_a: GO:0034501 ! protein localization to kinetochore
is_a: GO:0034629 ! cellular protein complex localization
created_by: midori
creation_date: 2010-11-15T11:30:38Z

[Term]
id: GO:0072357
name: PTW/PP1 phosphatase complex
namespace: cellular_component
def: "A protein serine/threonine phosphatase complex that contains a catalytic subunit (PPP1CA, PPP1CB or PPP1CC) and the regulatory subunits PPP1R10 (PNUTS), TOX4 and WDR82, and plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase." [GOC:mah, PMID:20516061]
is_a: GO:0008287 ! protein serine/threonine phosphatase complex
created_by: midori
creation_date: 2010-11-15T03:32:27Z

[Term]
id: GO:0072358
name: cardiovascular system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cardiovascular system over time, from its formation to the mature structure. The cardiovascular system is the anatomical system that has as its parts the heart and blood vessels." [GOC:mah, UBERON:0004535]
is_a: GO:0048731 ! system development
relationship: part_of GO:0072359 ! circulatory system development
created_by: midori
creation_date: 2010-11-16T11:25:49Z

[Term]
id: GO:0072359
name: circulatory system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis." [GOC:mah, UBERON:0001009]
is_a: GO:0048731 ! system development
created_by: midori
creation_date: 2010-11-16T11:27:39Z

[Term]
id: GO:0072360
name: vascular cord development
namespace: biological_process
def: "The progression of the vascular cord over time from its initial formation until its mature state. The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis." [GOC:mah, PMID:7084422, ZFA:0005077]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0072358 ! cardiovascular system development
created_by: midori
creation_date: 2010-11-16T11:46:55Z

[Term]
id: GO:0072361
name: regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glycolysis by modulating the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:BHF, GOC:mah]
is_a: GO:0006110 ! regulation of glycolytic process
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006096 ! glycolytic process
intersection_of: regulates GO:0006366 ! transcription from RNA polymerase II promoter
relationship: regulates GO:0006096 ! glycolytic process
relationship: regulates GO:0006366 ! transcription from RNA polymerase II promoter
created_by: midori
creation_date: 2010-11-16T02:57:18Z

[Term]
id: GO:0072362
name: regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glycolysis by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:BHF, GOC:mah]
synonym: "regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter" EXACT [GOC:bf]
is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
is_a: GO:0072361 ! regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: regulates GO:0006096 ! glycolytic process
relationship: negatively_regulates GO:0006366 ! transcription from RNA polymerase II promoter
relationship: regulates GO:0006096 ! glycolytic process
created_by: midori
creation_date: 2010-11-16T02:59:32Z

[Term]
id: GO:0072363
name: regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glycolysis by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:BHF, GOC:mah]
synonym: "regulation of glycolysis by positive regulation of transcription from an RNA polymerase II promoter" EXACT [GOC:bf]
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
is_a: GO:0072361 ! regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: regulates GO:0006096 ! glycolytic process
relationship: positively_regulates GO:0006366 ! transcription from RNA polymerase II promoter
relationship: regulates GO:0006096 ! glycolytic process
created_by: midori
creation_date: 2010-11-16T03:08:25Z

[Term]
id: GO:0072364
name: regulation of cellular ketone metabolic process by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a cellular ketone metabolic process by modulating the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:BHF, GOC:mah]
synonym: "regulation of cellular ketone metabolic process by regulation of transcription from an RNA polymerase II promoter" EXACT [GOC:bf]
synonym: "regulation of cellular ketone metabolism by regulation of transcription from an RNA polymerase II promoter" EXACT [GOC:mah]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0010565 ! regulation of cellular ketone metabolic process
intersection_of: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
intersection_of: regulates GO:0042180 ! cellular ketone metabolic process
relationship: regulates GO:0042180 ! cellular ketone metabolic process
created_by: midori
creation_date: 2010-11-16T03:11:39Z

[Term]
id: GO:0072365
name: regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a cellular ketone metabolic process by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:BHF, GOC:mah]
synonym: "regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter" EXACT [GOC:bf]
synonym: "regulation of cellular ketone metabolism by negative regulation of transcription from an RNA polymerase II promoter" EXACT [GOC:mah]
is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
is_a: GO:0072364 ! regulation of cellular ketone metabolic process by regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
intersection_of: regulates GO:0042180 ! cellular ketone metabolic process
relationship: regulates GO:0042180 ! cellular ketone metabolic process
created_by: midori
creation_date: 2010-11-16T03:12:09Z

[Term]
id: GO:0072366
name: regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a cellular ketone metabolic process by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:BHF, GOC:mah]
synonym: "regulation of cellular ketone metabolic process by positive regulation of transcription from an RNA polymerase II promoter" EXACT [GOC:bf]
synonym: "regulation of cellular ketone metabolism by positive regulation of transcription from an RNA polymerase II promoter" EXACT [GOC:mah]
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
is_a: GO:0072364 ! regulation of cellular ketone metabolic process by regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: regulates GO:0042180 ! cellular ketone metabolic process
relationship: positively_regulates GO:0006366 ! transcription from RNA polymerase II promoter
relationship: regulates GO:0042180 ! cellular ketone metabolic process
created_by: midori
creation_date: 2010-11-16T03:12:47Z

[Term]
id: GO:0072367
name: regulation of lipid transport by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lipid transport by modulating the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:BHF, GOC:mah]
synonym: "regulation of lipid transport by regulation of transcription from an RNA polymerase II promoter" EXACT [GOC:bf]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0032368 ! regulation of lipid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: regulates GO:0006869 ! lipid transport
relationship: regulates GO:0006366 ! transcription from RNA polymerase II promoter
relationship: regulates GO:0006869 ! lipid transport
created_by: midori
creation_date: 2010-11-16T03:17:54Z

[Term]
id: GO:0072368
name: regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lipid transport by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:BHF, GOC:mah]
synonym: "regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter" EXACT [GOC:bf]
is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
is_a: GO:0072367 ! regulation of lipid transport by regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: regulates GO:0006869 ! lipid transport
relationship: negatively_regulates GO:0006366 ! transcription from RNA polymerase II promoter
relationship: regulates GO:0006869 ! lipid transport
created_by: midori
creation_date: 2010-11-16T03:18:13Z

[Term]
id: GO:0072369
name: regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lipid transport by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:BHF, GOC:mah]
synonym: "regulation of lipid transport by positive regulation of transcription from an RNA polymerase II promoter" EXACT [GOC:bf]
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
is_a: GO:0072367 ! regulation of lipid transport by regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: regulates GO:0006869 ! lipid transport
relationship: positively_regulates GO:0006366 ! transcription from RNA polymerase II promoter
relationship: regulates GO:0006869 ! lipid transport
created_by: midori
creation_date: 2010-11-16T03:23:53Z

[Term]
id: GO:0072370
name: histone H2A-S121 phosphorylation
namespace: biological_process
def: "The modification of histone H2A by the addition of an phosphate group to a serine residue at position 121 of the histone." [GOC:mah, PMID:19965387]
synonym: "histone H2A phosphorylation at S121" EXACT [GOC:mah]
synonym: "histone H2AS121 phosphorylation" EXACT [GOC:mah]
is_a: GO:0035404 ! histone-serine phosphorylation
is_a: GO:1990164 ! histone H2A phosphorylation
created_by: midori
creation_date: 2010-11-16T03:42:52Z

[Term]
id: GO:0072371
name: histone kinase activity (H2A-S121 specific)
namespace: molecular_function
def: "Catalysis of the transfer of a phosphate group to the serine-121 residue of the N-terminal tail of histone H2A." [GOC:mah, PMID:19965387]
synonym: "histone serine kinase activity (H2A-S121 specific)" EXACT [GOC:mah]
synonym: "histone-serine kinase activity (H2A-S121 specific)" EXACT [GOC:mah]
is_a: GO:0035174 ! histone serine kinase activity
relationship: part_of GO:0072370 ! histone H2A-S121 phosphorylation
created_by: midori
creation_date: 2010-11-16T03:42:59Z

[Term]
id: GO:0072372
name: primary cilium
namespace: cellular_component
def: "A cilium found on many different cell types that is typically present in a single copy per cell. A primary cilium may have a variable array of axonemal microtubules and may or may not contain molecular motors." [GOC:curators, PMID:17009929, PMID:20144998]
is_a: GO:0005929 ! cilium
created_by: midori
creation_date: 2010-11-18T04:27:48Z

[Term]
id: GO:0072373
name: alpha-carotene epsilon hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-carotene + NADPH + O2 + H+ = alpha-cryptoxanthin + NADP+ + H2O." [GOC:mah, MetaCyc:CPD-7421, MetaCyc:CPD1F-118, MetaCyc:RXN-5962]
xref: EC:1.14.99.-
is_a: GO:0072374 ! carotene epsilon hydroxylase activity
created_by: midori
creation_date: 2010-11-19T03:52:25Z

[Term]
id: GO:0072374
name: carotene epsilon hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: a carotene + NADPH + O2 + H+ = a beta-ring hydroxylcarotene + NADP+ + H2O. Adds a hydroxyl group to the epsilon ring of the alpha-carotene." [GOC:mah, MetaCyc:CPD-7421, MetaCyc:CPD1F-118, MetaCyc:RXN-5962]
xref: EC:1.14.99.-
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
created_by: midori
creation_date: 2010-11-19T03:57:55Z

[Term]
id: GO:0072375
name: medium-term memory
namespace: biological_process
def: "The memory process that deals with the storage, retrieval and modification of information received at a time ago that is intermediate between that of short and long term memory (30min - 7hrs in Drosophila melanogaster)." [GOC:sart, PMID:14659098, PMID:7923375]
synonym: "middle-term memory" EXACT [GOC:sart]
synonym: "MTM" NARROW [GOC:sart]
is_a: GO:0007613 ! memory
created_by: midori
creation_date: 2010-11-22T11:26:54Z

[Term]
id: GO:0072376
name: protein activation cascade
namespace: biological_process
def: "A response to a stimulus that consists of a sequential series of modifications to a set of proteins where the product of one reaction acts catalytically in the following reaction. The magnitude of the response is typically amplified at each successive step in the cascade. Modifications typically include proteolysis or covalent modification, and may also include binding events." [GOC:add, GOC:mah, GOC:pde]
synonym: "protein activation pathway" EXACT [GOC:add]
synonym: "protein activitory cascade" EXACT [GOC:add]
is_a: GO:0019538 ! protein metabolic process
is_a: GO:0044710 ! single-organism metabolic process
is_a: GO:0050896 ! response to stimulus
created_by: midori
creation_date: 2010-11-22T02:54:18Z

[Term]
id: GO:0072377
name: blood coagulation, common pathway
namespace: biological_process
def: "A protein activation cascade that contributes to blood coagulation and consists of events leading from the formation of activated factor X to the formation of active thrombin, the cleavage of fibrinogen by thrombin, and the formation of cleaved fibrin into a stable multimeric, cross-linked complex." [GOC:add, GOC:mah, GOC:pde, PMID:1931959]
comment: See also the biological process term 'blood coagulation, intrinsic pathway ; GO:0007597'.
is_a: GO:0072376 ! protein activation cascade
relationship: part_of GO:0072378 ! blood coagulation, fibrin clot formation
created_by: midori
creation_date: 2010-11-22T03:01:12Z

[Term]
id: GO:0072378
name: blood coagulation, fibrin clot formation
namespace: biological_process
def: "A protein activation cascade that contributes to blood coagulation and consists of the cascade of enzymatic reactions initiated by physical damage to the wall of a blood vessel, leading to the formation of a formation of a fibrin clot at the site of the injury. The process also includes numerous positive and negative regulatory events." [GOC:add, GOC:mah, GOC:pde]
comment: See also the biological process term 'blood coagulation, intrinsic pathway ; GO:0007597'.
is_a: GO:0072376 ! protein activation cascade
relationship: part_of GO:0007596 ! blood coagulation
created_by: midori
creation_date: 2010-11-22T03:09:32Z

[Term]
id: GO:0072379
name: ER membrane insertion complex
namespace: cellular_component
def: "A protein complex that is involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum. TA membrane proteins, also called type II transmembrane proteins, contain a single C-terminal transmembrane region. Some ER membrane insertion complex subunits are conserved between different species such as mammals and budding yeast." [GOC:mah, PMID:20676083, PMID:20850366]
synonym: "endoplasmic reticulum membrane insertion complex" EXACT [GOC:mah]
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part
created_by: midori
creation_date: 2010-11-24T02:07:09Z

[Term]
id: GO:0072380
name: TRC complex
namespace: cellular_component
def: "An ER membrane insertion complex that contains subunits that recognize two types of transmembrane domain signals. In budding yeast the complex contains Get4p, Get5p, Sgt2p, and at least two heat shock proteins (HSPs)." [GOC:mah, PMID:20850366]
synonym: "TMD recognition complex" EXACT [PMID:20850366]
is_a: GO:0072379 ! ER membrane insertion complex
created_by: midori
creation_date: 2010-11-24T02:43:41Z

[Term]
id: GO:0072381
name: positive regulation of canonical Wnt signaling pathway involved in neural crest cell differentiation
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin involved in neural crest cell differentiation. The Wnt signaling pathway is the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:mah]
synonym: "positive regulation of canonical Wnt receptor signaling pathway involved in neural crest cell differentiation" EXACT []
synonym: "positive regulation of canonical Wnt receptor signalling pathway involved in neural crest cell differentiation" EXACT [GOC:mah]
synonym: "positive regulation of canonical Wnt-activated signaling pathway involved in neural crest cell differentiation" EXACT [GOC:signaling]
synonym: "positive regulation of Wnt receptor signaling pathway through beta-catenin involved in neural crest cell differentiation" EXACT [GOC:mah]
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0072335 ! regulation of canonical Wnt signaling pathway involved in neural crest cell differentiation
is_a: GO:0090263 ! positive regulation of canonical Wnt signaling pathway
is_a: GO:2000738 ! positive regulation of stem cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044335 ! canonical Wnt signaling pathway involved in neural crest cell differentiation
relationship: positively_regulates GO:0044335 ! canonical Wnt signaling pathway involved in neural crest cell differentiation
created_by: midori
creation_date: 2010-11-24T03:10:15Z

[Term]
id: GO:0072382
name: minus-end-directed vesicle transport along microtubule
namespace: biological_process
def: "The directed movement of a vesicle towards the minus end of a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination." [GOC:BHF, GOC:mah]
synonym: "microtubule minus-end-directed vesicle distribution" NARROW [GOC:rl]
synonym: "microtubule minus-end-directed vesicle localization" EXACT [GOC:rl]
is_a: GO:0047496 ! vesicle transport along microtubule
is_a: GO:0072385 ! minus-end-directed organelle transport along microtubule
created_by: midori
creation_date: 2010-12-01T04:12:59Z

[Term]
id: GO:0072383
name: plus-end-directed vesicle transport along microtubule
namespace: biological_process
def: "The directed movement of a vesicle towards the plus end of a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination." [GOC:BHF, GOC:mah]
synonym: "microtubule plus-end-directed vesicle distribution" NARROW [GOC:rl]
synonym: "microtubule plus-end-directed vesicle localization" EXACT [GOC:rl]
is_a: GO:0047496 ! vesicle transport along microtubule
is_a: GO:0072386 ! plus-end-directed organelle transport along microtubule
created_by: midori
creation_date: 2010-12-01T04:24:51Z

[Term]
id: GO:0072384
name: organelle transport along microtubule
namespace: biological_process
def: "The directed movement of an organelle along a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination." [GOC:mah]
synonym: "microtubule-based organelle localization" EXACT [GOC:rl]
is_a: GO:0010970 ! establishment of localization by movement along microtubule
is_a: GO:0030705 ! cytoskeleton-dependent intracellular transport
is_a: GO:0051656 ! establishment of organelle localization
is_a: GO:1902580 ! single-organism cellular localization
created_by: midori
creation_date: 2010-12-01T04:59:11Z

[Term]
id: GO:0072385
name: minus-end-directed organelle transport along microtubule
namespace: biological_process
def: "The directed movement of an organelle towards the minus end of a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination." [GOC:BHF, GOC:mah]
synonym: "microtubule minus-end-directed organelle distribution" NARROW [GOC:rl]
synonym: "microtubule minus-end-directed organelle localization" EXACT [GOC:rl]
is_a: GO:0072384 ! organelle transport along microtubule
created_by: midori
creation_date: 2010-12-01T05:01:20Z

[Term]
id: GO:0072386
name: plus-end-directed organelle transport along microtubule
namespace: biological_process
def: "The directed movement of an organelle towards the plus end of a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination." [GOC:BHF, GOC:mah]
synonym: "microtubule plus-end-directed organelle distribution" NARROW [GOC:rl]
synonym: "microtubule plus-end-directed organelle localization" EXACT [GOC:rl]
is_a: GO:0072384 ! organelle transport along microtubule
created_by: midori
creation_date: 2010-12-01T05:02:09Z

[Term]
id: GO:0072387
name: flavin adenine dinucleotide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving flavin adenine dinucleotide, which acts as a coenzyme or prosthetic group of various flavoprotein oxidoreductase enzymes." [CHEBI:24040, GOC:mah]
synonym: "FAD or FADH2 metabolic process" EXACT [GOC:curators]
synonym: "flavin adenine dinucleotide metabolism" EXACT [GOC:curators]
synonym: "flavin-adenine dinucleotide metabolic process" EXACT [GOC:curators]
is_a: GO:0006732 ! coenzyme metabolic process
is_a: GO:0009117 ! nucleotide metabolic process
is_a: GO:0042726 ! flavin-containing compound metabolic process
created_by: midori
creation_date: 2010-12-02T04:21:43Z

[Term]
id: GO:0072388
name: flavin adenine dinucleotide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of flavin adenine dinucleotide, which acts as a coenzyme or prosthetic group of various flavoprotein oxidoreductase enzymes." [CHEBI:24040, GOC:mah]
synonym: "FAD or FADH2 biosynthetic process" EXACT [GOC:curators]
synonym: "flavin adenine dinucleotide anabolism" EXACT [GOC:curators]
synonym: "flavin adenine dinucleotide biosynthesis" EXACT [GOC:curators]
synonym: "flavin adenine dinucleotide formation" EXACT [GOC:curators]
synonym: "flavin adenine dinucleotide synthesis" EXACT [GOC:curators]
is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0009165 ! nucleotide biosynthetic process
is_a: GO:0042727 ! flavin-containing compound biosynthetic process
is_a: GO:0072387 ! flavin adenine dinucleotide metabolic process
created_by: midori
creation_date: 2010-12-02T04:26:34Z

[Term]
id: GO:0072389
name: flavin adenine dinucleotide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of flavin adenine dinucleotide, which acts as a coenzyme or prosthetic group of various flavoprotein oxidoreductase enzymes." [CHEBI:24040, GOC:mah]
synonym: "FAD or FADH2 catabolic process" EXACT [GOC:curators]
synonym: "flavin adenine dinucleotide breakdown" EXACT [GOC:curators]
synonym: "flavin adenine dinucleotide catabolism" EXACT [GOC:curators]
synonym: "flavin adenine dinucleotide degradation" EXACT [GOC:curators]
is_a: GO:0009109 ! coenzyme catabolic process
is_a: GO:0009166 ! nucleotide catabolic process
is_a: GO:0042728 ! flavin-containing compound catabolic process
is_a: GO:0072387 ! flavin adenine dinucleotide metabolic process
created_by: midori
creation_date: 2010-12-02T04:28:02Z

[Term]
id: GO:0072390
name: phenol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phenol, a compound that consists of a benzene ring with one attached hydroxyl group." [CHEBI:15882, GOC:mah]
is_a: GO:0018958 ! phenol-containing compound metabolic process
created_by: midori
creation_date: 2010-12-06T04:05:51Z

[Term]
id: GO:0072391
name: phenol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phenol, a compound that consists of a benzene ring with one attached hydroxyl group." [CHEBI:15882, GOC:mah]
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:0072390 ! phenol metabolic process
created_by: midori
creation_date: 2010-12-06T04:08:04Z

[Term]
id: GO:0072392
name: phenol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phenol, a compound that consists of a benzene ring with one attached hydroxyl group." [CHEBI:15882, GOC:mah]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0072390 ! phenol metabolic process
created_by: midori
creation_date: 2010-12-06T04:08:44Z

[Term]
id: GO:0072393
name: microtubule anchoring at microtubule organizing center
namespace: biological_process
def: "Any process in which a microtubule is maintained in a specific location in a cell by attachment to a microtubule organizing center." [GOC:BHF, PMID:19825938]
synonym: "microtubule anchoring at microtubule organising centre" EXACT [GOC:mah]
synonym: "microtubule anchoring at MTOC" EXACT [GOC:BHF]
is_a: GO:0034453 ! microtubule anchoring
created_by: midori
creation_date: 2010-12-07T11:54:35Z

[Term]
id: GO:0072394
name: detection of stimulus involved in cell cycle checkpoint
namespace: biological_process
alt_id: GO:0072403
alt_id: GO:0072406
def: "The series of events in which information about a biological process or quality is received and converted into a molecular signal, contributing to a cell cycle checkpoint." [GOC:mtg_cell_cycle]
synonym: "cell cycle checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "cell cycle checkpoint sensor process" RELATED [GOC:mah]
synonym: "detection of stimulus involved in G1/S transition checkpoint" RELATED []
synonym: "detection of stimulus involved in G2/M transition checkpoint" RELATED []
synonym: "G1/S transition checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "G1/S transition checkpoint sensor process" RELATED [GOC:mah]
synonym: "G2/M transition checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "G2/M transition checkpoint sensor process" RELATED [GOC:mah]
synonym: "sensing involved in cell cycle checkpoint" RELATED [GOC:mah]
synonym: "sensing involved in G1/S transition checkpoint" RELATED [GOC:mah]
synonym: "sensing involved in G2/M transition checkpoint" RELATED [GOC:mah]
is_a: GO:0090429 ! detection of endogenous biotic stimulus
intersection_of: GO:0090429 ! detection of endogenous biotic stimulus
intersection_of: part_of GO:0000075 ! cell cycle checkpoint
relationship: part_of GO:0000075 ! cell cycle checkpoint
created_by: midori
creation_date: 2010-12-08T02:55:56Z

[Term]
id: GO:0072395
name: signal transduction involved in cell cycle checkpoint
namespace: biological_process
alt_id: GO:0072404
alt_id: GO:0072407
def: "A signal transduction process that contributes to a cell cycle checkpoint." [GOC:mtg_cell_cycle]
synonym: "signal transduction involved in G2/M transition checkpoint" EXACT []
is_a: GO:0022402 ! cell cycle process
is_a: GO:0035556 ! intracellular signal transduction
is_a: GO:1901988 ! negative regulation of cell cycle phase transition
intersection_of: GO:0035556 ! intracellular signal transduction
intersection_of: part_of GO:0000075 ! cell cycle checkpoint
relationship: part_of GO:0000075 ! cell cycle checkpoint
created_by: midori
creation_date: 2010-12-08T02:59:45Z

[Term]
id: GO:0072396
name: response to cell cycle checkpoint signaling
namespace: biological_process
alt_id: GO:0072405
alt_id: GO:0072408
def: "A process that occurs in response to signals generated as a result of cell cycle checkpoint signaling." [GOC:mtg_cell_cycle]
synonym: "cell cycle checkpoint effector process" EXACT [GOC:mah]
synonym: "G1/S transition checkpoint effector process" RELATED [GOC:mah]
synonym: "G2/M transition checkpoint effector process" RELATED [GOC:mah]
synonym: "response to G1/S transition checkpoint signaling" RELATED []
synonym: "response to G2/M transition checkpoint signaling" RELATED []
synonym: "response to signal involved in cell cycle checkpoint" EXACT [GOC:mah]
synonym: "response to signal involved in G1/S transition checkpoint" RELATED [GOC:mah]
synonym: "response to signal involved in G2/M transition checkpoint" RELATED [GOC:mah]
is_a: GO:0071216 ! cellular response to biotic stimulus
is_a: GO:0071495 ! cellular response to endogenous stimulus
created_by: midori
creation_date: 2010-12-08T03:05:46Z

[Term]
id: GO:0072397
name: detection of stimulus involved in cytokinesis checkpoint
namespace: biological_process
alt_id: GO:0072418
def: "The series of events in which information about the formation and integrity of cytokinetic structures, such as the contractile ring, is received and converted into a molecular signal, contributing to a cytokinesis checkpoint." [GOC:mtg_cell_cycle]
synonym: "cytokinesis checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "cytokinesis checkpoint sensor process" RELATED [GOC:mah]
synonym: "detection of stimulus involved in septin checkpoint" EXACT []
synonym: "sensing involved in cytokinesis checkpoint" RELATED [GOC:mah]
synonym: "sensing involved in septin checkpoint" RELATED [GOC:mah]
synonym: "septin checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "septin checkpoint sensor process" RELATED [GOC:mah]
is_a: GO:0072394 ! detection of stimulus involved in cell cycle checkpoint
created_by: midori
creation_date: 2010-12-08T03:18:11Z

[Term]
id: GO:0072398
name: signal transduction involved in cytokinesis checkpoint
namespace: biological_process
alt_id: GO:0072419
def: "A signal transduction process that contributes to a cytokinesis checkpoint." [GOC:mtg_cell_cycle]
synonym: "signal transduction involved in septin checkpoint" EXACT []
is_a: GO:0072395 ! signal transduction involved in cell cycle checkpoint
created_by: midori
creation_date: 2010-12-08T03:22:21Z

[Term]
id: GO:0072399
name: response to cytokinesis checkpoint signaling
namespace: biological_process
alt_id: GO:0072420
def: "A process that occurs in response to signals generated as a result of cytokinesis checkpoint signaling." [GOC:mtg_cell_cycle]
synonym: "cytokinesis checkpoint effector process" EXACT [GOC:mah]
synonym: "response to septin checkpoint signaling" EXACT []
synonym: "response to signal involved in cytokinesis checkpoint" EXACT [GOC:mah]
synonym: "response to signal involved in septin checkpoint" EXACT [GOC:mah]
synonym: "septin checkpoint effector process" EXACT [GOC:mah]
is_a: GO:0072396 ! response to cell cycle checkpoint signaling
created_by: midori
creation_date: 2010-12-08T03:23:32Z

[Term]
id: GO:0072400
name: detection of stimulus involved in mitotic DNA integrity checkpoint
namespace: biological_process
alt_id: GO:0072457
def: "The series of events in which information about DNA integrity is received and converted into a molecular signal, contributing to a mitotic DNA integrity checkpoint." [GOC:mtg_cell_cycle]
synonym: "detection of stimulus involved in mitotic G2/M transition decatenation checkpoint" RELATED []
synonym: "DNA integrity checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "DNA integrity checkpoint sensor process" RELATED [GOC:mah]
synonym: "mitotic G2/M transition decatenation checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "mitotic G2/M transition decatenation checkpoint sensor process" RELATED [GOC:mah]
synonym: "sensing involved in DNA integrity checkpoint" RELATED [GOC:mah]
synonym: "sensing involved in mitotic G2/M transition decatenation checkpoint" RELATED [GOC:mah]
is_a: GO:0072412 ! detection of stimulus involved in mitotic cell cycle checkpoint
intersection_of: GO:0051606 ! detection of stimulus
intersection_of: part_of GO:0044774 ! mitotic DNA integrity checkpoint
relationship: part_of GO:0044774 ! mitotic DNA integrity checkpoint
created_by: midori
creation_date: 2010-12-08T03:29:11Z

[Term]
id: GO:0072401
name: signal transduction involved in DNA integrity checkpoint
namespace: biological_process
def: "A signal transduction process that contributes to a DNA integrity checkpoint." [GOC:mah]
is_a: GO:0072395 ! signal transduction involved in cell cycle checkpoint
intersection_of: GO:0035556 ! intracellular signal transduction
intersection_of: part_of GO:0031570 ! DNA integrity checkpoint
relationship: part_of GO:0031570 ! DNA integrity checkpoint
created_by: midori
creation_date: 2010-12-08T03:31:56Z

[Term]
id: GO:0072402
name: response to DNA integrity checkpoint signaling
namespace: biological_process
def: "A process that occurs in response to signals generated as a result of DNA integrity checkpoint signaling." [GOC:mtg_cell_cycle]
synonym: "DNA integrity checkpoint effector process" EXACT [GOC:mah]
synonym: "response to signal involved in DNA integrity checkpoint" EXACT [GOC:mah]
is_a: GO:0072396 ! response to cell cycle checkpoint signaling
created_by: midori
creation_date: 2010-12-08T03:32:17Z

[Term]
id: GO:0072409
name: detection of stimulus involved in meiotic cell cycle checkpoint
namespace: biological_process
def: "The series of events in which information about a biological process or quality is received and converted into a molecular signal, contributing to a meiotic cell cycle checkpoint." [GOC:mah, GOC:mtg_cell_cycle]
synonym: "meiotic cell cycle checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "meiotic cell cycle checkpoint sensor process" RELATED [GOC:mah]
synonym: "sensing involved in meiotic cell cycle checkpoint" RELATED [GOC:mah]
is_a: GO:0022414 ! reproductive process
is_a: GO:0072394 ! detection of stimulus involved in cell cycle checkpoint
intersection_of: GO:0090429 ! detection of endogenous biotic stimulus
intersection_of: part_of GO:0033313 ! meiotic cell cycle checkpoint
relationship: part_of GO:0033313 ! meiotic cell cycle checkpoint
created_by: midori
creation_date: 2010-12-08T03:47:50Z

[Term]
id: GO:0072410
name: response to meiotic cell cycle checkpoint signaling
namespace: biological_process
def: "A process that acts directly to delay or stop progression through the cell cycle in response to signals generated as a result of meiotic cell cycle checkpoint signaling; contributes to a meiotic cell cycle checkpoint." [GOC:mah]
synonym: "meiotic cell cycle checkpoint effector process" EXACT [GOC:mah]
synonym: "response to signal involved in meiotic cell cycle checkpoint" EXACT [GOC:mah]
is_a: GO:0072396 ! response to cell cycle checkpoint signaling
created_by: midori
creation_date: 2010-12-08T03:48:38Z

[Term]
id: GO:0072411
name: signal transduction involved in meiotic cell cycle checkpoint
namespace: biological_process
def: "A signal transduction process that contributes to a meiotic cell cycle checkpoint." [GOC:mah]
is_a: GO:0072395 ! signal transduction involved in cell cycle checkpoint
is_a: GO:1903046 ! meiotic cell cycle process
intersection_of: GO:0035556 ! intracellular signal transduction
intersection_of: part_of GO:0033313 ! meiotic cell cycle checkpoint
relationship: part_of GO:0033313 ! meiotic cell cycle checkpoint
created_by: midori
creation_date: 2010-12-08T03:48:45Z

[Term]
id: GO:0072412
name: detection of stimulus involved in mitotic cell cycle checkpoint
namespace: biological_process
alt_id: GO:0072454
alt_id: GO:0072472
def: "The series of events in which information about a biological process or quality is received and converted into a molecular signal, contributing to a mitotic cell cycle checkpoint." [GOC:mtg_cell_cycle]
synonym: "detection of stimulus involved in mitotic cell cycle G1/S checkpoint" RELATED []
synonym: "mitotic cell cycle checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "mitotic cell cycle checkpoint sensor process" RELATED [GOC:mah]
synonym: "mitotic cell cycle G1/S checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "mitotic cell cycle G1/S checkpoint sensor process" RELATED [GOC:mah]
synonym: "sensing involved in mitotic cell cycle checkpoint" RELATED [GOC:mah]
synonym: "sensing involved in mitotic cell cycle G1/S checkpoint" RELATED [GOC:mah]
is_a: GO:0072394 ! detection of stimulus involved in cell cycle checkpoint
intersection_of: GO:0051606 ! detection of stimulus
intersection_of: part_of GO:0007093 ! mitotic cell cycle checkpoint
relationship: part_of GO:0007093 ! mitotic cell cycle checkpoint
created_by: midori
creation_date: 2010-12-08T03:48:57Z

[Term]
id: GO:0072413
name: signal transduction involved in mitotic cell cycle checkpoint
namespace: biological_process
alt_id: GO:0072456
alt_id: GO:0072474
def: "A signal transduction process that contributes to a mitotic cell cycle checkpoint." [GOC:mtg_cell_cycle]
synonym: "signal transduction involved in mitotic cell cycle G1/S checkpoint" RELATED []
synonym: "signal transduction involved in mitotic G2/M transition checkpoint" RELATED []
is_a: GO:0072395 ! signal transduction involved in cell cycle checkpoint
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0035556 ! intracellular signal transduction
intersection_of: part_of GO:0007093 ! mitotic cell cycle checkpoint
relationship: part_of GO:0007093 ! mitotic cell cycle checkpoint
created_by: midori
creation_date: 2010-12-08T03:50:28Z

[Term]
id: GO:0072414
name: response to mitotic cell cycle checkpoint signaling
namespace: biological_process
alt_id: GO:0072455
alt_id: GO:0072473
def: "A process that occurs in response to signals generated as a result of mitotic cell cycle checkpoint signaling." [GOC:mtg_cell_cycle]
synonym: "mitotic cell cycle checkpoint effector process" EXACT [GOC:mah]
synonym: "mitotic cell cycle G1/S checkpoint effector process" RELATED [GOC:mah]
synonym: "mitotic G2/M transition checkpoint effector process" RELATED [GOC:mah]
synonym: "response to mitotic cell cycle G1/S checkpoint signaling" RELATED []
synonym: "response to mitotic G2/M transition checkpoint signal" RELATED []
synonym: "response to signal involved in mitotic cell cycle checkpoint" RELATED [GOC:mah]
synonym: "response to signal involved in mitotic cell cycle G1/S checkpoint" RELATED [GOC:mah]
synonym: "response to signal involved in mitotic G2/M transition checkpoint" RELATED [GOC:mah]
is_a: GO:0072396 ! response to cell cycle checkpoint signaling
created_by: midori
creation_date: 2010-12-08T03:50:43Z

[Term]
id: GO:0072415
name: detection of stimulus involved in spindle checkpoint
namespace: biological_process
def: "The series of events in which information about the assembly, orientation or integrity of the spindle is received and converted into a molecular signal, contributing to a spindle checkpoint." [GOC:mah, GOC:mtg_cell_cycle]
synonym: "sensing involved in spindle checkpoint" RELATED [GOC:mah]
synonym: "spindle checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "spindle checkpoint sensor process" RELATED [GOC:mah]
is_a: GO:0072394 ! detection of stimulus involved in cell cycle checkpoint
intersection_of: GO:0090429 ! detection of endogenous biotic stimulus
intersection_of: part_of GO:0031577 ! spindle checkpoint
relationship: part_of GO:0031577 ! spindle checkpoint
created_by: midori
creation_date: 2010-12-08T03:54:50Z

[Term]
id: GO:0072416
name: signal transduction involved in spindle checkpoint
namespace: biological_process
def: "A signal transduction process that contributes to a spindle checkpoint." [GOC:mah]
is_a: GO:0072395 ! signal transduction involved in cell cycle checkpoint
intersection_of: GO:0035556 ! intracellular signal transduction
intersection_of: part_of GO:0031577 ! spindle checkpoint
relationship: part_of GO:0031577 ! spindle checkpoint
created_by: midori
creation_date: 2010-12-08T03:55:51Z

[Term]
id: GO:0072417
name: response to spindle checkpoint signaling
namespace: biological_process
def: "A process that occurs in response to signals generated as a result of spindle checkpoint signaling." [GOC:mtg_cell_cycle]
synonym: "response to signal involved in spindle checkpoint" EXACT [GOC:mah]
synonym: "spindle checkpoint effector process" EXACT [GOC:mah]
is_a: GO:0072396 ! response to cell cycle checkpoint signaling
created_by: midori
creation_date: 2010-12-08T03:56:04Z

[Term]
id: GO:0072421
name: detection of DNA damage stimulus involved in DNA damage checkpoint
namespace: biological_process
def: "The series of events in which information about damage to DNA is received and converted into a molecular signal, contributing to a DNA damage checkpoint." [GOC:mtg_cell_cycle]
synonym: "DNA damage checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "DNA damage checkpoint sensor process" RELATED [GOC:mah]
synonym: "sensing involved in DNA damage checkpoint" RELATED [GOC:mah]
is_a: GO:0022402 ! cell cycle process
is_a: GO:0042769 ! DNA damage response, detection of DNA damage
intersection_of: GO:0042769 ! DNA damage response, detection of DNA damage
intersection_of: part_of GO:0000077 ! DNA damage checkpoint
relationship: part_of GO:0000077 ! DNA damage checkpoint
created_by: midori
creation_date: 2010-12-08T04:16:04Z

[Term]
id: GO:0072422
name: signal transduction involved in DNA damage checkpoint
namespace: biological_process
def: "A signal transduction process that contributes to a DNA damage checkpoint." [GOC:mah]
is_a: GO:0042770 ! signal transduction in response to DNA damage
is_a: GO:0072401 ! signal transduction involved in DNA integrity checkpoint
intersection_of: GO:0035556 ! intracellular signal transduction
intersection_of: part_of GO:0000077 ! DNA damage checkpoint
relationship: part_of GO:0000077 ! DNA damage checkpoint
created_by: midori
creation_date: 2010-12-08T04:18:11Z

[Term]
id: GO:0072423
name: response to DNA damage checkpoint signaling
namespace: biological_process
def: "A process that occurs in response to signals generated as a result of DNA damage checkpoint signaling." [GOC:mtg_cell_cycle]
synonym: "DNA damage checkpoint effector process" EXACT [GOC:mah]
synonym: "response to signal involved in DNA damage checkpoint" EXACT [GOC:mah]
is_a: GO:0072402 ! response to DNA integrity checkpoint signaling
created_by: midori
creation_date: 2010-12-08T04:20:25Z

[Term]
id: GO:0072424
name: detection of DNA damage stimulus involved in G2 DNA damage checkpoint
namespace: biological_process
def: "The series of events in which information about damage to DNA is received and converted into a molecular signal, contributing to a G2/M transition DNA damage checkpoint." [GOC:mtg_cell_cycle]
synonym: "detection of DNA damage stimulus involved in G2/M transition DNA damage checkpoint" EXACT []
synonym: "G2/M transition DNA damage checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "G2/M transition DNA damage checkpoint sensor process" RELATED [GOC:mah]
synonym: "sensing involved in G2/M transition DNA damage checkpoint" RELATED [GOC:mah]
is_a: GO:0072421 ! detection of DNA damage stimulus involved in DNA damage checkpoint
intersection_of: GO:0042769 ! DNA damage response, detection of DNA damage
intersection_of: part_of GO:0031572 ! G2 DNA damage checkpoint
relationship: part_of GO:0031572 ! G2 DNA damage checkpoint
created_by: midori
creation_date: 2010-12-08T04:24:59Z

[Term]
id: GO:0072425
name: signal transduction involved in G2 DNA damage checkpoint
namespace: biological_process
def: "A signal transduction process that contributes to a G2/M transition DNA damage checkpoint." [GOC:mtg_cell_cycle]
synonym: "signal transduction involved in G2/M transition DNA damage checkpoint" EXACT []
is_a: GO:0072422 ! signal transduction involved in DNA damage checkpoint
is_a: GO:1902750 ! negative regulation of cell cycle G2/M phase transition
intersection_of: GO:0035556 ! intracellular signal transduction
intersection_of: part_of GO:0031572 ! G2 DNA damage checkpoint
relationship: part_of GO:0031572 ! G2 DNA damage checkpoint
created_by: midori
creation_date: 2010-12-08T04:25:26Z

[Term]
id: GO:0072426
name: response to G2 DNA damage checkpoint signaling
namespace: biological_process
def: "A process that occurs in response to signals generated as a result of G2/M transition DNA damage checkpoint signaling." [GOC:mtg_cell_cycle]
synonym: "G2/M transition DNA damage checkpoint effector process" EXACT [GOC:mah]
synonym: "response to signal involved in G2/M transition DNA damage checkpoint" EXACT [GOC:mah]
is_a: GO:0072423 ! response to DNA damage checkpoint signaling
created_by: midori
creation_date: 2010-12-08T04:26:35Z

[Term]
id: GO:0072427
name: detection of DNA damage stimulus involved in intra-S DNA damage checkpoint
namespace: biological_process
def: "The series of events in which information about damage to DNA is received and converted into a molecular signal, contributing to an intra-S DNA damage checkpoint." [GOC:mah]
synonym: "intra-S DNA damage checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "intra-S DNA damage checkpoint sensor process" RELATED [GOC:mah]
synonym: "sensing involved in intra-S DNA damage checkpoint" RELATED [GOC:mah]
is_a: GO:0072421 ! detection of DNA damage stimulus involved in DNA damage checkpoint
is_a: GO:1902401 ! detection of stimulus involved in mitotic DNA damage checkpoint
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0042769 ! DNA damage response, detection of DNA damage
intersection_of: part_of GO:0031573 ! intra-S DNA damage checkpoint
relationship: part_of GO:0031573 ! intra-S DNA damage checkpoint
created_by: midori
creation_date: 2010-12-08T04:30:27Z

[Term]
id: GO:0072428
name: signal transduction involved in intra-S DNA damage checkpoint
namespace: biological_process
def: "A signal transduction process that contributes to an intra-S DNA damage checkpoint." [GOC:mah]
is_a: GO:1902402 ! signal transduction involved in mitotic DNA damage checkpoint
is_a: GO:1903464 ! negative regulation of mitotic cell cycle DNA replication
intersection_of: GO:0035556 ! intracellular signal transduction
intersection_of: part_of GO:0031573 ! intra-S DNA damage checkpoint
relationship: part_of GO:0031573 ! intra-S DNA damage checkpoint
created_by: midori
creation_date: 2010-12-08T04:31:08Z

[Term]
id: GO:0072429
name: response to intra-S DNA damage checkpoint signaling
namespace: biological_process
def: "A process that occurs in response to signals generated as a result of intra-S DNA damage checkpoint signaling." [GOC:mtg_cell_cycle]
synonym: "intra-S DNA damage checkpoint effector process" EXACT [GOC:mah]
synonym: "response to signal involved in intra-S DNA damage checkpoint" EXACT [GOC:mah]
is_a: GO:0072423 ! response to DNA damage checkpoint signaling
created_by: midori
creation_date: 2010-12-08T04:31:56Z

[Term]
id: GO:0072430
name: detection of DNA damage stimulus involved in mitotic G1 DNA damage checkpoint
namespace: biological_process
def: "The series of events in which information about damage to DNA is received and converted into a molecular signal, contributing to a mitotic cell cycle G1/S transition DNA damage checkpoint." [GOC:mtg_cell_cycle]
synonym: "detection of DNA damage stimulus involved in mitotic cell cycle G1/S transition DNA damage checkpoint" EXACT []
synonym: "mitotic cell cycle G1/S transition DNA damage checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "mitotic cell cycle G1/S transition DNA damage checkpoint sensor process" RELATED [GOC:mah]
synonym: "sensing involved in mitotic cell cycle G1/S transition DNA damage checkpoint" RELATED [GOC:mah]
is_a: GO:0072421 ! detection of DNA damage stimulus involved in DNA damage checkpoint
is_a: GO:1902399 ! detection of stimulus involved in G1 DNA damage checkpoint
is_a: GO:1902401 ! detection of stimulus involved in mitotic DNA damage checkpoint
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0042769 ! DNA damage response, detection of DNA damage
intersection_of: part_of GO:0031571 ! mitotic G1 DNA damage checkpoint
relationship: part_of GO:0007093 ! mitotic cell cycle checkpoint
relationship: part_of GO:0031571 ! mitotic G1 DNA damage checkpoint
created_by: midori
creation_date: 2010-12-08T04:37:40Z

[Term]
id: GO:0072431
name: signal transduction involved in mitotic G1 DNA damage checkpoint
namespace: biological_process
def: "A signal transduction process that contributes to a mitotic cell cycle G1/S transition DNA damage checkpoint." [GOC:mtg_cell_cycle]
synonym: "signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint" EXACT []
is_a: GO:1902400 ! intracellular signal transduction involved in G1 DNA damage checkpoint
is_a: GO:1902402 ! signal transduction involved in mitotic DNA damage checkpoint
is_a: GO:2000134 ! negative regulation of G1/S transition of mitotic cell cycle
intersection_of: GO:0035556 ! intracellular signal transduction
intersection_of: part_of GO:0031571 ! mitotic G1 DNA damage checkpoint
relationship: part_of GO:0031571 ! mitotic G1 DNA damage checkpoint
created_by: midori
creation_date: 2010-12-08T04:37:55Z

[Term]
id: GO:0072432
name: response to G1 DNA damage checkpoint signaling
namespace: biological_process
def: "A process that occurs in response to signals generated as a result of G1/S transition DNA damage checkpoint signaling." [GOC:mtg_cell_cycle]
synonym: "mitotic cell cycle G1/S transition DNA damage checkpoint effector process" EXACT [GOC:mah]
synonym: "response to mitotic cell cycle G1/S transition DNA damage checkpoint signaling" EXACT []
synonym: "response to signal involved in mitotic cell cycle G1/S transition DNA damage checkpoint" EXACT [GOC:mah]
is_a: GO:0072414 ! response to mitotic cell cycle checkpoint signaling
is_a: GO:0072423 ! response to DNA damage checkpoint signaling
created_by: midori
creation_date: 2010-12-08T04:38:04Z

[Term]
id: GO:0072433
name: detection of DNA damage stimulus involved in mitotic G2 DNA damage checkpoint
namespace: biological_process
def: "The series of events in which information about damage to DNA is received and converted into a molecular signal, contributing to a mitotic G2/M transition DNA damage checkpoint." [GOC:mtg_cell_cycle]
synonym: "detection of DNA damage stimulus involved in mitotic G2/M transition DNA damage checkpoint" EXACT []
synonym: "mitotic G2/M transition DNA damage checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "mitotic G2/M transition DNA damage checkpoint sensor process" RELATED [GOC:mah]
synonym: "sensing involved in mitotic G2/M transition DNA damage checkpoint" RELATED [GOC:mah]
is_a: GO:0072424 ! detection of DNA damage stimulus involved in G2 DNA damage checkpoint
is_a: GO:1902401 ! detection of stimulus involved in mitotic DNA damage checkpoint
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0042769 ! DNA damage response, detection of DNA damage
intersection_of: part_of GO:0007095 ! mitotic G2 DNA damage checkpoint
relationship: part_of GO:0007095 ! mitotic G2 DNA damage checkpoint
created_by: midori
creation_date: 2010-12-08T04:43:14Z

[Term]
id: GO:0072434
name: signal transduction involved in mitotic G2 DNA damage checkpoint
namespace: biological_process
def: "A signal transduction process that contributes to a mitotic G2/M transition DNA damage checkpoint." [GOC:mtg_cell_cycle]
synonym: "signal transduction involved in mitotic G2/M transition DNA damage checkpoint" EXACT []
is_a: GO:0010972 ! negative regulation of G2/M transition of mitotic cell cycle
is_a: GO:0072425 ! signal transduction involved in G2 DNA damage checkpoint
is_a: GO:1902402 ! signal transduction involved in mitotic DNA damage checkpoint
intersection_of: GO:0007165 ! signal transduction
intersection_of: part_of GO:0007095 ! mitotic G2 DNA damage checkpoint
relationship: part_of GO:0007095 ! mitotic G2 DNA damage checkpoint
created_by: midori
creation_date: 2010-12-08T04:43:48Z

[Term]
id: GO:0072435
name: response to mitotic G2 DNA damage checkpoint signaling
namespace: biological_process
alt_id: GO:0072458
def: "A process that occurs in response to signals generated as a result of mitotic G2/M transition DNA damage checkpoint signaling." [GOC:mtg_cell_cycle]
synonym: "mitotic G2/M transition decatenation checkpoint effector process" RELATED [GOC:mah]
synonym: "mitotic G2/M transition DNA damage checkpoint effector process" EXACT [GOC:mah]
synonym: "response to mitotic G2/M transition decatenation checkpoint signaling" RELATED []
synonym: "response to mitotic G2/M transition DNA damage checkpoint signaling" EXACT []
synonym: "response to signal involved in mitotic G2/M transition decatenation checkpoint" RELATED [GOC:mah]
synonym: "response to signal involved in mitotic G2/M transition DNA damage checkpoint" EXACT [GOC:mah]
is_a: GO:0072414 ! response to mitotic cell cycle checkpoint signaling
is_a: GO:0072426 ! response to G2 DNA damage checkpoint signaling
created_by: midori
creation_date: 2010-12-08T04:44:01Z

[Term]
id: GO:0072436
name: detection of stimulus involved in DNA replication checkpoint
namespace: biological_process
def: "The series of events in which information about whether DNA replication is complete is received and converted into a molecular signal, contributing to a DNA replication checkpoint." [GOC:mtg_cell_cycle]
synonym: "DNA replication checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "DNA replication checkpoint sensor process" RELATED [GOC:mah]
synonym: "sensing involved in DNA replication checkpoint" RELATED [GOC:mah]
is_a: GO:0022402 ! cell cycle process
is_a: GO:0042769 ! DNA damage response, detection of DNA damage
intersection_of: GO:0051606 ! detection of stimulus
intersection_of: part_of GO:0000076 ! DNA replication checkpoint
relationship: part_of GO:0000076 ! DNA replication checkpoint
created_by: midori
creation_date: 2010-12-08T04:52:09Z

[Term]
id: GO:0072437
name: signal transduction involved in DNA replication checkpoint
namespace: biological_process
def: "A signal transduction process that contributes to a DNA replication checkpoint." [GOC:mah]
is_a: GO:0072401 ! signal transduction involved in DNA integrity checkpoint
intersection_of: GO:0035556 ! intracellular signal transduction
intersection_of: part_of GO:0000076 ! DNA replication checkpoint
relationship: part_of GO:0000076 ! DNA replication checkpoint
created_by: midori
creation_date: 2010-12-08T04:52:31Z

[Term]
id: GO:0072438
name: response to DNA replication checkpoint signaling
namespace: biological_process
def: "A process that occurs in response to signals generated as a result of DNA replication checkpoint signaling." [GOC:mtg_cell_cycle]
synonym: "DNA replication checkpoint effector process" EXACT [GOC:mah]
synonym: "response to signal involved in DNA replication checkpoint" EXACT [GOC:mah]
is_a: GO:0072402 ! response to DNA integrity checkpoint signaling
created_by: midori
creation_date: 2010-12-08T04:53:12Z

[Term]
id: GO:0072439
name: detection of stimulus involved in meiotic DNA replication checkpoint
namespace: biological_process
def: "The series of events in which information about whether DNA replication is complete is received and converted into a molecular signal, contributing to a meiotic DNA replication checkpoint." [GOC:mtg_cell_cycle]
synonym: "meiotic DNA replication checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "meiotic DNA replication checkpoint sensor process" RELATED [GOC:mah]
synonym: "sensing involved in meiotic DNA replication checkpoint" RELATED [GOC:mah]
is_a: GO:0072409 ! detection of stimulus involved in meiotic cell cycle checkpoint
is_a: GO:0072436 ! detection of stimulus involved in DNA replication checkpoint
is_a: GO:1903046 ! meiotic cell cycle process
intersection_of: GO:0051606 ! detection of stimulus
intersection_of: part_of GO:0033315 ! meiotic DNA replication checkpoint
relationship: part_of GO:0033315 ! meiotic DNA replication checkpoint
created_by: midori
creation_date: 2010-12-08T04:59:08Z

[Term]
id: GO:0072440
name: signal transduction involved in meiotic DNA replication checkpoint
namespace: biological_process
def: "A signal transduction process that contributes to a meiotic DNA replication checkpoint." [GOC:mah]
is_a: GO:0072411 ! signal transduction involved in meiotic cell cycle checkpoint
is_a: GO:0072437 ! signal transduction involved in DNA replication checkpoint
intersection_of: GO:0035556 ! intracellular signal transduction
intersection_of: part_of GO:0033315 ! meiotic DNA replication checkpoint
relationship: part_of GO:0033315 ! meiotic DNA replication checkpoint
created_by: midori
creation_date: 2010-12-08T04:59:18Z

[Term]
id: GO:0072441
name: response to meiotic DNA replication checkpoint signaling
namespace: biological_process
def: "A process that occurs in response to signals generated as a result of meiotic DNA replication checkpoint signaling." [GOC:mtg_cell_cycle]
synonym: "meiotic DNA replication checkpoint effector process" EXACT [GOC:mah]
synonym: "response to signal involved in meiotic DNA replication checkpoint" EXACT [GOC:mah]
is_a: GO:0072410 ! response to meiotic cell cycle checkpoint signaling
is_a: GO:0072438 ! response to DNA replication checkpoint signaling
created_by: midori
creation_date: 2010-12-08T04:59:26Z

[Term]
id: GO:0072442
name: detection of stimulus involved in mitotic DNA replication checkpoint
namespace: biological_process
alt_id: GO:0072445
def: "The series of events in which information about whether DNA replication is complete is received and converted into a molecular signal, contributing to a mitotic DNA replication checkpoint." [GOC:mtg_cell_cycle]
synonym: "detection of stimulus involved in S-M checkpoint" RELATED []
synonym: "mitotic DNA replication checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "mitotic DNA replication checkpoint sensor process" RELATED [GOC:mah]
synonym: "S-M checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "S-M checkpoint sensor process" RELATED [GOC:mah]
synonym: "sensing involved in mitotic DNA replication checkpoint" RELATED [GOC:mah]
synonym: "sensing involved in S-M checkpoint" RELATED [GOC:mah]
is_a: GO:0072400 ! detection of stimulus involved in mitotic DNA integrity checkpoint
is_a: GO:0072436 ! detection of stimulus involved in DNA replication checkpoint
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0051606 ! detection of stimulus
intersection_of: part_of GO:0033314 ! mitotic DNA replication checkpoint
relationship: part_of GO:0033314 ! mitotic DNA replication checkpoint
created_by: midori
creation_date: 2010-12-08T05:12:49Z

[Term]
id: GO:0072443
name: signal transduction involved in mitotic DNA replication checkpoint
namespace: biological_process
alt_id: GO:0072446
alt_id: GO:0072459
def: "A signal transduction process that contributes to a mitotic DNA replication checkpoint." [GOC:mtg_cell_cycle]
synonym: "signal transduction involved in mitotic G2/M transition decatenation checkpoint" RELATED []
synonym: "signal transduction involved in S-M checkpoint" EXACT []
is_a: GO:0072437 ! signal transduction involved in DNA replication checkpoint
is_a: GO:1902403 ! signal transduction involved in mitotic DNA integrity checkpoint
intersection_of: GO:0035556 ! intracellular signal transduction
intersection_of: part_of GO:0033314 ! mitotic DNA replication checkpoint
relationship: part_of GO:0033314 ! mitotic DNA replication checkpoint
created_by: midori
creation_date: 2010-12-08T05:12:56Z

[Term]
id: GO:0072444
name: response to mitotic DNA replication checkpoint signaling
namespace: biological_process
alt_id: GO:0072447
def: "A process that occurs in response to signals generated as a result of mitotic DNA replication checkpoint signaling." [GOC:mtg_cell_cycle]
synonym: "mitotic DNA replication checkpoint effector process" EXACT [GOC:mah]
synonym: "response to S-M checkpoint signaling" EXACT []
synonym: "response to signal involved in mitotic DNA replication checkpoint" EXACT [GOC:mah]
synonym: "response to signal involved in S-M checkpoint" EXACT [GOC:mah]
synonym: "S-M checkpoint effector process" EXACT [GOC:mah]
is_a: GO:0072414 ! response to mitotic cell cycle checkpoint signaling
is_a: GO:0072438 ! response to DNA replication checkpoint signaling
created_by: midori
creation_date: 2010-12-08T05:13:27Z

[Term]
id: GO:0072448
name: detection of stimulus involved in G1 cell size control checkpoint
namespace: biological_process
def: "The series of events in which information about cell size is received and converted into a molecular signal, contributing to a mitotic cell cycle G1/S transition size control checkpoint." [GOC:mtg_cell_cycle]
synonym: "detection of stimulus involved in mitotic cell cycle G1/S transition size control checkpoint" RELATED []
synonym: "mitotic cell cycle G1/S transition size control checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "mitotic cell cycle G1/S transition size control checkpoint sensor process" RELATED [GOC:mah]
synonym: "sensing involved in mitotic cell cycle G1/S transition size control checkpoint" RELATED [GOC:mah]
is_a: GO:0072469 ! detection of stimulus involved in cell size control checkpoint
intersection_of: GO:0051606 ! detection of stimulus
intersection_of: part_of GO:0031568 ! G1 cell size control checkpoint
relationship: part_of GO:0031567 ! mitotic cell size control checkpoint
relationship: part_of GO:0031568 ! G1 cell size control checkpoint
created_by: midori
creation_date: 2010-12-09T10:56:32Z

[Term]
id: GO:0072449
name: response to G1 cell size control checkpoint signaling
namespace: biological_process
def: "A process that occurs in response to signals generated as a result of mitotic cell cycle G1/S transition size control checkpoint signaling." [GOC:mtg_cell_cycle]
synonym: "mitotic cell cycle G1/S transition size control checkpoint effector process" EXACT [GOC:mah]
synonym: "response to signal involved in mitotic cell cycle G1/S transition size control checkpoint" EXACT [GOC:mah]
is_a: GO:0072470 ! response to cell size control checkpoint signaling
created_by: midori
creation_date: 2010-12-09T10:56:39Z

[Term]
id: GO:0072450
name: signal transduction involved in G1 cell size control checkpoint
namespace: biological_process
def: "A signal transduction process that contributes to a mitotic cell cycle G1/S transition size control checkpoint." [GOC:mah]
synonym: "signal transduction involved in mitotic cell cycle G1/S transition size control checkpoint" EXACT []
is_a: GO:0072471 ! signal transduction involved in cell size control checkpoint
intersection_of: GO:0035556 ! intracellular signal transduction
intersection_of: part_of GO:0031568 ! G1 cell size control checkpoint
relationship: part_of GO:0031567 ! mitotic cell size control checkpoint
relationship: part_of GO:0031568 ! G1 cell size control checkpoint
created_by: midori
creation_date: 2010-12-09T10:56:44Z

[Term]
id: GO:0072451
name: detection of stimulus involved in G2 cell size control checkpoint
namespace: biological_process
def: "The series of events in which information about cell size is received and converted into a molecular signal, contributing to a G2/M transition size control checkpoint." [GOC:mtg_cell_cycle]
synonym: "detection of stimulus involved in G2/M transition size control checkpoint" EXACT []
synonym: "detection of stimulus involved in mitotic cell cycle G2/M transition size control checkpoint" RELATED [GOC:mah]
synonym: "G2/M transition size control checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "G2/M transition size control checkpoint sensor process" RELATED [GOC:mah]
synonym: "sensing involved in G2/M transition size control checkpoint" RELATED [GOC:mah]
is_a: GO:0072469 ! detection of stimulus involved in cell size control checkpoint
intersection_of: GO:0051606 ! detection of stimulus
intersection_of: part_of GO:0031569 ! G2 cell size control checkpoint
relationship: part_of GO:0031569 ! G2 cell size control checkpoint
created_by: midori
creation_date: 2010-12-09T11:14:00Z

[Term]
id: GO:0072452
name: response to G2 transition size control checkpoint signaling
namespace: biological_process
def: "A process that occurs in response to signals generated as a result of G2/M transition size control checkpoint signaling." [GOC:mtg_cell_cycle]
synonym: "G2/M transition size control checkpoint effector process" EXACT [GOC:mah]
synonym: "response to G2/M transition size control checkpoint signaling" EXACT []
synonym: "response to mitotic cell cycle G2/M transition size control checkpoint signaling" EXACT [GOC:mah]
synonym: "response to signal involved in G2/M transition size control checkpoint" EXACT [GOC:mah]
is_a: GO:0072470 ! response to cell size control checkpoint signaling
created_by: midori
creation_date: 2010-12-09T11:14:12Z

[Term]
id: GO:0072453
name: signal transduction involved in G2 cell size control checkpoint
namespace: biological_process
def: "A signal transduction process that contributes to a G2/M transition size control checkpoint." [GOC:mtg_cell_cycle]
synonym: "signal transduction involved in G2/M transition size control checkpoint" EXACT []
synonym: "signal transduction involved in mitotic cell cycle G2/M transition size control checkpoint" EXACT [GOC:mah]
is_a: GO:0072471 ! signal transduction involved in cell size control checkpoint
intersection_of: GO:0035556 ! intracellular signal transduction
intersection_of: part_of GO:0031569 ! G2 cell size control checkpoint
relationship: part_of GO:0031569 ! G2 cell size control checkpoint
created_by: midori
creation_date: 2010-12-09T11:14:22Z

[Term]
id: GO:0072460
name: detection of stimulus involved in meiotic recombination checkpoint
namespace: biological_process
def: "The series of events in which information about whether recombination is complete is received and converted into a molecular signal, contributing to a meiotic recombination checkpoint." [GOC:mah]
synonym: "meiotic recombination checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "meiotic recombination checkpoint sensor process" RELATED [GOC:mah]
synonym: "sensing involved in meiotic recombination checkpoint" RELATED [GOC:mah]
is_a: GO:0072409 ! detection of stimulus involved in meiotic cell cycle checkpoint
intersection_of: GO:0072409 ! detection of stimulus involved in meiotic cell cycle checkpoint
intersection_of: part_of GO:0051598 ! meiotic recombination checkpoint
relationship: part_of GO:0051598 ! meiotic recombination checkpoint
created_by: midori
creation_date: 2010-12-09T11:36:42Z

[Term]
id: GO:0072461
name: response to meiotic recombination checkpoint signaling
namespace: biological_process
def: "A process that occurs in response to signals generated as a result of meiotic recombination checkpoint signaling." [GOC:mtg_cell_cycle]
synonym: "meiotic recombination checkpoint effector process" EXACT [GOC:mah]
synonym: "response to signal involved in meiotic recombination checkpoint" EXACT [GOC:mah]
is_a: GO:0072410 ! response to meiotic cell cycle checkpoint signaling
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0051598 ! meiotic recombination checkpoint
created_by: midori
creation_date: 2010-12-09T11:37:01Z

[Term]
id: GO:0072462
name: signal transduction involved in meiotic recombination checkpoint
namespace: biological_process
def: "A signal transduction process that contributes to a meiotic recombination checkpoint." [GOC:mah]
is_a: GO:0072411 ! signal transduction involved in meiotic cell cycle checkpoint
intersection_of: GO:0035556 ! intracellular signal transduction
intersection_of: part_of GO:0051598 ! meiotic recombination checkpoint
relationship: part_of GO:0051598 ! meiotic recombination checkpoint
created_by: midori
creation_date: 2010-12-09T11:37:17Z

[Term]
id: GO:0072463
name: detection of stimulus involved in meiotic spindle assembly checkpoint
namespace: biological_process
def: "The series of events in which information about whether spindle is correctly assembled and chromosomes are attached to the spindle is received and converted into a molecular signal, contributing to a meiotic spindle assembly checkpoint." [GOC:mah]
synonym: "meiotic spindle assembly checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "meiotic spindle assembly checkpoint sensor process" RELATED [GOC:mah]
synonym: "sensing involved in meiotic spindle assembly checkpoint" RELATED [GOC:mah]
is_a: GO:0072409 ! detection of stimulus involved in meiotic cell cycle checkpoint
is_a: GO:0072484 ! detection of stimulus involved in spindle assembly checkpoint
is_a: GO:1902397 ! detection of stimulus involved in meiotic spindle checkpoint
intersection_of: GO:0051606 ! detection of stimulus
intersection_of: part_of GO:0033316 ! meiotic spindle assembly checkpoint
relationship: part_of GO:0033316 ! meiotic spindle assembly checkpoint
created_by: midori
creation_date: 2010-12-09T11:37:41Z

[Term]
id: GO:0072464
name: response to meiotic spindle assembly checkpoint signaling
namespace: biological_process
def: "A process that occurs in response to signals generated as a result of meiotic spindle assembly checkpoint signaling." [GOC:mtg_cell_cycle]
synonym: "meiotic spindle assembly checkpoint effector process" EXACT [GOC:mah]
synonym: "response to signal involved in meiotic spindle assembly checkpoint" EXACT [GOC:mah]
is_a: GO:0072410 ! response to meiotic cell cycle checkpoint signaling
is_a: GO:0072485 ! response to spindle assembly checkpoint signaling
created_by: midori
creation_date: 2010-12-09T11:37:48Z

[Term]
id: GO:0072465
name: signal transduction involved in meiotic spindle assembly checkpoint
namespace: biological_process
def: "A signal transduction process that contributes to a meiotic spindle assembly checkpoint." [GOC:mtg_cell_cycle]
is_a: GO:0072486 ! signal transduction involved in spindle assembly checkpoint
is_a: GO:1902398 ! intracellular signal transduction involved in meiotic spindle checkpoint
intersection_of: GO:0035556 ! intracellular signal transduction
intersection_of: part_of GO:0033316 ! meiotic spindle assembly checkpoint
relationship: part_of GO:0033316 ! meiotic spindle assembly checkpoint
created_by: midori
creation_date: 2010-12-09T11:37:54Z

[Term]
id: GO:0072466
name: obsolete detection of stimulus involved in cell shape checkpoint
namespace: biological_process
def: "The series of events in which information about aspects of cell polarity control is received and converted into a molecular signal, contributing to a cell shape checkpoint." [GOC:mah, GOC:mtg_cell_cycle]
comment: This term was made obsolete because it was ambiguous.
synonym: "cell shape checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "cell shape checkpoint sensor process" RELATED [GOC:mah]
synonym: "sensing involved in cell shape checkpoint" RELATED [GOC:mah]
is_obsolete: true
created_by: midori
creation_date: 2010-12-09T11:43:58Z

[Term]
id: GO:0072467
name: obsolete response to cell shape checkpoint signaling
namespace: biological_process
def: "A process that occurs in response to signals generated as a result of cell shape checkpoint signaling." [GOC:mtg_cell_cycle]
comment: This term was made obsolete because it was ambiguous.
synonym: "cell shape checkpoint effector process" EXACT [GOC:mah]
synonym: "response to signal involved in cell shape checkpoint" EXACT [GOC:mah]
is_obsolete: true
created_by: midori
creation_date: 2010-12-09T11:44:11Z

[Term]
id: GO:0072468
name: obsolete signal transduction involved in cell shape checkpoint
namespace: biological_process
def: "A signal transduction process that contributes to a cell shape checkpoint." [GOC:mah]
comment: This term was made obsolete because it was ambiguous.
is_obsolete: true
created_by: midori
creation_date: 2010-12-09T11:45:12Z

[Term]
id: GO:0072469
name: detection of stimulus involved in cell size control checkpoint
namespace: biological_process
def: "The series of events in which information about cell size is received and converted into a molecular signal, contributing to a cell size control checkpoint." [GOC:mtg_cell_cycle]
synonym: "cell size control checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "cell size control checkpoint sensor process" RELATED [GOC:mah]
synonym: "detection of stimulus involved in mitotic cell cycle cell size control checkpoint" EXACT [GOC:mah]
synonym: "sensing involved in cell size control checkpoint" RELATED [GOC:mah]
is_a: GO:0072412 ! detection of stimulus involved in mitotic cell cycle checkpoint
intersection_of: GO:0051606 ! detection of stimulus
intersection_of: part_of GO:0031567 ! mitotic cell size control checkpoint
relationship: part_of GO:0031567 ! mitotic cell size control checkpoint
created_by: midori
creation_date: 2010-12-09T11:46:08Z

[Term]
id: GO:0072470
name: response to cell size control checkpoint signaling
namespace: biological_process
def: "A process that occurs in response to signals generated as a result of cell size control checkpoint signaling." [GOC:mtg_cell_cycle]
synonym: "cell size control checkpoint effector process" EXACT [GOC:mah]
synonym: "response to mitotic cell cycle cell size control checkpoint signaling" EXACT [GOC:mah]
synonym: "response to signal involved in cell size control checkpoint" EXACT [GOC:mah]
is_a: GO:0072414 ! response to mitotic cell cycle checkpoint signaling
created_by: midori
creation_date: 2010-12-09T11:46:13Z

[Term]
id: GO:0072471
name: signal transduction involved in cell size control checkpoint
namespace: biological_process
def: "A signal transduction process that contributes to a cell size control checkpoint." [GOC:mtg_cell_cycle]
is_a: GO:0072413 ! signal transduction involved in mitotic cell cycle checkpoint
intersection_of: GO:0035556 ! intracellular signal transduction
intersection_of: part_of GO:0031567 ! mitotic cell size control checkpoint
relationship: part_of GO:0031567 ! mitotic cell size control checkpoint
created_by: midori
creation_date: 2010-12-09T11:46:18Z

[Term]
id: GO:0072475
name: detection of stimulus involved in mitotic spindle checkpoint
namespace: biological_process
def: "The series of events in which information about whether the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle, is received and converted into a molecular signal, contributing to a mitotic cell cycle spindle checkpoint." [GOC:mtg_cell_cycle]
synonym: "detection of stimulus involved in mitotic cell cycle spindle checkpoint" EXACT []
synonym: "mitotic cell cycle spindle checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "mitotic cell cycle spindle checkpoint sensor process" RELATED [GOC:mah]
synonym: "sensing involved in mitotic cell cycle spindle checkpoint" RELATED [GOC:mah]
is_a: GO:0072412 ! detection of stimulus involved in mitotic cell cycle checkpoint
is_a: GO:0072415 ! detection of stimulus involved in spindle checkpoint
intersection_of: GO:0051606 ! detection of stimulus
intersection_of: part_of GO:0071174 ! mitotic spindle checkpoint
relationship: part_of GO:0071174 ! mitotic spindle checkpoint
created_by: midori
creation_date: 2010-12-09T11:49:55Z

[Term]
id: GO:0072476
name: response to mitotic spindle checkpoint signaling
namespace: biological_process
def: "A process that occurs in response to signals generated as a result of mitotic cell cycle spindle checkpoint signaling." [GOC:mtg_cell_cycle]
synonym: "mitotic cell cycle spindle checkpoint effector process" EXACT [GOC:mah]
synonym: "response to mitotic cell cycle spindle checkpoint signaling" EXACT []
synonym: "response to signal involved in mitotic cell cycle spindle checkpoint" EXACT [GOC:mah]
is_a: GO:0072414 ! response to mitotic cell cycle checkpoint signaling
is_a: GO:0072417 ! response to spindle checkpoint signaling
created_by: midori
creation_date: 2010-12-09T11:50:09Z

[Term]
id: GO:0072477
name: signal transduction involved in mitotic spindle checkpoint
namespace: biological_process
def: "A signal transduction process that contributes to a mitotic cell cycle spindle checkpoint." [GOC:mtg_cell_cycle]
synonym: "signal transduction involved in mitotic cell cycle spindle checkpoint" EXACT []
is_a: GO:0023019 ! signal transduction involved in regulation of gene expression
is_a: GO:0072413 ! signal transduction involved in mitotic cell cycle checkpoint
is_a: GO:0072416 ! signal transduction involved in spindle checkpoint
intersection_of: GO:0035556 ! intracellular signal transduction
intersection_of: part_of GO:0071174 ! mitotic spindle checkpoint
relationship: part_of GO:0071174 ! mitotic spindle checkpoint
created_by: midori
creation_date: 2010-12-09T11:50:16Z

[Term]
id: GO:0072478
name: detection of stimulus involved in mitotic spindle assembly checkpoint
namespace: biological_process
def: "The series of events in which information about whether the spindle is correctly assembled, and chromosomes are attached to the spindle, is received and converted into a molecular signal, contributing to a mitotic cell cycle spindle assembly checkpoint." [GOC:mtg_cell_cycle]
synonym: "detection of stimulus involved in mitotic cell cycle spindle assembly checkpoint" EXACT []
synonym: "mitotic cell cycle spindle assembly checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "mitotic cell cycle spindle assembly checkpoint sensor process" RELATED [GOC:mah]
synonym: "sensing involved in mitotic cell cycle spindle assembly checkpoint" RELATED [GOC:mah]
is_a: GO:0072475 ! detection of stimulus involved in mitotic spindle checkpoint
is_a: GO:0072484 ! detection of stimulus involved in spindle assembly checkpoint
intersection_of: GO:0051606 ! detection of stimulus
intersection_of: part_of GO:0007094 ! mitotic spindle assembly checkpoint
relationship: part_of GO:0007094 ! mitotic spindle assembly checkpoint
created_by: midori
creation_date: 2010-12-09T12:11:18Z

[Term]
id: GO:0072479
name: response to mitotic cell cycle spindle assembly checkpoint signaling
namespace: biological_process
def: "A process that occurs in response to signals generated as a result of mitotic cell cycle spindle assembly checkpoint signaling." [GOC:mtg_cell_cycle]
synonym: "mitotic cell cycle spindle assembly checkpoint effector process" EXACT [GOC:mah]
synonym: "response to signal involved in mitotic cell cycle spindle assembly checkpoint" EXACT [GOC:mah]
is_a: GO:0072476 ! response to mitotic spindle checkpoint signaling
is_a: GO:0072485 ! response to spindle assembly checkpoint signaling
created_by: midori
creation_date: 2010-12-09T12:11:31Z

[Term]
id: GO:0072480
name: signal transduction involved in mitotic spindle assembly checkpoint
namespace: biological_process
def: "A signal transduction process that contributes to a mitotic cell cycle spindle assembly checkpoint." [GOC:mtg_cell_cycle]
synonym: "signal transduction involved in mitotic cell cycle spindle assembly checkpoint" EXACT []
is_a: GO:0072477 ! signal transduction involved in mitotic spindle checkpoint
is_a: GO:0072486 ! signal transduction involved in spindle assembly checkpoint
intersection_of: GO:0035556 ! intracellular signal transduction
intersection_of: part_of GO:0007094 ! mitotic spindle assembly checkpoint
relationship: part_of GO:0007094 ! mitotic spindle assembly checkpoint
created_by: midori
creation_date: 2010-12-09T12:11:42Z

[Term]
id: GO:0072481
name: detection of stimulus involved in mitotic spindle orientation checkpoint
namespace: biological_process
def: "The series of events in which information about whether the spindle is correctly oriented is received and converted into a molecular signal, contributing to a mitotic cell cycle spindle orientation checkpoint." [GOC:mtg_cell_cycle]
synonym: "detection of stimulus involved in mitotic cell cycle spindle orientation checkpoint" EXACT []
synonym: "mitotic cell cycle spindle orientation checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "mitotic cell cycle spindle orientation checkpoint sensor process" RELATED [GOC:mah]
synonym: "sensing involved in mitotic cell cycle spindle orientation checkpoint" RELATED [GOC:mah]
is_a: GO:0072475 ! detection of stimulus involved in mitotic spindle checkpoint
intersection_of: GO:0051606 ! detection of stimulus
intersection_of: part_of GO:0031578 ! mitotic spindle orientation checkpoint
relationship: part_of GO:0031578 ! mitotic spindle orientation checkpoint
created_by: midori
creation_date: 2010-12-09T12:11:52Z

[Term]
id: GO:0072482
name: response to mitotic cell cycle spindle orientation checkpoint signaling
namespace: biological_process
def: "A process that occurs in response to signals generated as a result of mitotic cell cycle spindle orientation checkpoint signaling." [GOC:mtg_cell_cycle]
synonym: "mitotic cell cycle spindle orientation checkpoint effector process" EXACT [GOC:mah]
synonym: "response to signal involved in mitotic cell cycle spindle orientation checkpoint" EXACT [GOC:mah]
is_a: GO:0072476 ! response to mitotic spindle checkpoint signaling
created_by: midori
creation_date: 2010-12-09T12:11:56Z

[Term]
id: GO:0072483
name: signal transduction involved in mitotic cell cycle spindle orientation checkpoint
namespace: biological_process
def: "A signal transduction process that contributes to a mitotic cell cycle spindle orientation checkpoint." [GOC:mtg_cell_cycle]
is_a: GO:0072477 ! signal transduction involved in mitotic spindle checkpoint
intersection_of: GO:0035556 ! intracellular signal transduction
intersection_of: part_of GO:0031578 ! mitotic spindle orientation checkpoint
relationship: part_of GO:0031578 ! mitotic spindle orientation checkpoint
created_by: midori
creation_date: 2010-12-09T12:12:00Z

[Term]
id: GO:0072484
name: detection of stimulus involved in spindle assembly checkpoint
namespace: biological_process
def: "The series of events in which information about spindle assembly is received and converted into a molecular signal, contributing to a spindle assembly checkpoint." [GOC:mah]
synonym: "sensing involved in spindle assembly checkpoint" RELATED [GOC:mah]
synonym: "spindle assembly checkpoint sensor mechanism" RELATED [GOC:mah]
synonym: "spindle assembly checkpoint sensor process" RELATED [GOC:mah]
is_a: GO:0072415 ! detection of stimulus involved in spindle checkpoint
intersection_of: GO:0051606 ! detection of stimulus
intersection_of: part_of GO:0071173 ! spindle assembly checkpoint
relationship: part_of GO:0071173 ! spindle assembly checkpoint
created_by: midori
creation_date: 2010-12-09T12:19:16Z

[Term]
id: GO:0072485
name: response to spindle assembly checkpoint signaling
namespace: biological_process
def: "A process that occurs in response to signals generated as a result of spindle assembly checkpoint signaling." [GOC:mtg_cell_cycle]
synonym: "response to signal involved in spindle assembly checkpoint" EXACT [GOC:mah]
synonym: "spindle assembly checkpoint effector process" EXACT [GOC:mah]
is_a: GO:0072417 ! response to spindle checkpoint signaling
created_by: midori
creation_date: 2010-12-09T12:19:35Z

[Term]
id: GO:0072486
name: signal transduction involved in spindle assembly checkpoint
namespace: biological_process
def: "A signal transduction process that contributes to a spindle assembly checkpoint." [GOC:mtg_cell_cycle]
is_a: GO:0072416 ! signal transduction involved in spindle checkpoint
intersection_of: GO:0035556 ! intracellular signal transduction
intersection_of: part_of GO:0071173 ! spindle assembly checkpoint
relationship: part_of GO:0071173 ! spindle assembly checkpoint
created_by: midori
creation_date: 2010-12-09T12:19:51Z

[Term]
id: GO:0072487
name: MSL complex
namespace: cellular_component
def: "A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residue at position 16. In human, it contains the catalytic subunit MOF, and MSL1, MSL2 and MSL3." [PMID:16227571, PMID:20018852]
is_a: GO:0000123 ! histone acetyltransferase complex
created_by: midori
creation_date: 2010-12-10T10:15:11Z

[Term]
id: GO:0072488
name: ammonium transmembrane transport
namespace: biological_process
def: "The directed movement of ammonium across a membrane by means of some agent such as a transporter or pore. Ammonium is the cation NH4+." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "ammonium membrane transport" EXACT []
is_a: GO:0015696 ! ammonium transport
is_a: GO:0098662 ! inorganic cation transmembrane transport
created_by: midori
creation_date: 2010-12-10T10:29:57Z

[Term]
id: GO:0072489
name: methylammonium transmembrane transport
namespace: biological_process
def: "The directed movement of methylammonium across a membrane by means of some agent such as a transporter or pore." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "methylammonium membrane transport" EXACT []
is_a: GO:0015843 ! methylammonium transport
is_a: GO:0072488 ! ammonium transmembrane transport
created_by: midori
creation_date: 2010-12-10T10:36:33Z

[Term]
id: GO:0072490
name: toluene-containing compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving toluene, methylbenzene (formula C7H8), or any of its derivatives." [CHEBI:27024, GOC:mah]
synonym: "toluene and derivative metabolic process" EXACT [GOC:mah]
synonym: "toluene-containing compound metabolism" EXACT [GOC:mah]
is_a: GO:0042537 ! benzene-containing compound metabolic process
created_by: midori
creation_date: 2010-12-14T03:46:52Z

[Term]
id: GO:0072491
name: toluene-containing compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of toluene, methylbenzene (formula C7H8), or any of its derivatives." [CHEBI:27024, GOC:mah]
synonym: "toluene and derivative catabolic process" EXACT [GOC:mah]
synonym: "toluene-containing compound breakdown" EXACT [GOC:mah]
synonym: "toluene-containing compound catabolism" EXACT [GOC:mah]
synonym: "toluene-containing compound degradation" EXACT [GOC:mah]
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0072490 ! toluene-containing compound metabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
created_by: midori
creation_date: 2010-12-14T03:51:03Z

[Term]
id: GO:0072492
name: host cell mitochondrial intermembrane space
namespace: cellular_component
def: "The region between the inner and outer lipid bilayers of the host cell mitochondrial envelope." [GOC:ecd]
subset: gosubset_prok
is_a: GO:0033655 ! host cell cytoplasm part
relationship: part_of GO:0044190 ! host cell mitochondrial envelope
created_by: midori
creation_date: 2010-12-15T11:44:02Z

[Term]
id: GO:0072493
name: host cell endosome lumen
namespace: cellular_component
def: "The volume enclosed by the membranes of the host cell endosome." [GOC:ecd]
subset: gosubset_prok
synonym: "host endosome lumen" EXACT [GOC:mah]
is_a: GO:0033655 ! host cell cytoplasm part
relationship: part_of GO:0044174 ! host cell endosome
created_by: midori
creation_date: 2010-12-15T11:45:53Z

[Term]
id: GO:0072494
name: host multivesicular body
namespace: cellular_component
def: "A late endosome in which regions of the limiting host cell endosomal membrane invaginate to form internal vesicles; host membrane proteins that enter the internal vesicles are sequestered from the host cytoplasm." [GOC:rph]
subset: gosubset_prok
synonym: "host cell multivesicular body" EXACT [GOC:mah]
is_a: GO:0044184 ! host cell late endosome
created_by: midori
creation_date: 2010-12-15T11:48:39Z

[Term]
id: GO:0072495
name: host cell Cajal body
namespace: cellular_component
def: "A class of nuclear body in the eukaryotic host cell, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA. The host is the larger of the organisms involved in a symbiotic interaction." [GOC:rph]
subset: gosubset_prok
synonym: "coiled body of host" EXACT [GOC:rph]
synonym: "host cell coiled body" EXACT [GOC:mah]
is_a: GO:0044094 ! host cell nuclear part
relationship: part_of GO:0044095 ! host cell nucleoplasm
created_by: midori
creation_date: 2010-12-15T11:51:12Z

[Term]
id: GO:0072496
name: Pup transferase activity
namespace: molecular_function
def: "Catalysis of the transfer of Pup from one protein to another via the reaction X-Pup + Y --> Y-Pup + X, where both X-Pup and Y-Pup are covalent linkages." [GOC:sp]
synonym: "Pup conjugating enzyme activity" NARROW [GOC:mah]
is_a: GO:0019787 ! ubiquitin-like protein transferase activity
created_by: midori
creation_date: 2010-12-15T11:58:13Z

[Term]
id: GO:0072497
name: mesenchymal stem cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal stem cell. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [CL:0002452, GOC:BHF]
is_a: GO:0048863 ! stem cell differentiation
created_by: midori
creation_date: 2010-12-15T12:59:30Z

[Term]
id: GO:0072498
name: embryonic skeletal joint development
namespace: biological_process
def: "The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeletal joints over time, from formation to mature structure." [GOC:BHF, GOC:vk]
is_a: GO:0048706 ! embryonic skeletal system development
created_by: midori
creation_date: 2010-12-15T04:14:42Z

[Term]
id: GO:0072499
name: photoreceptor cell axon guidance
namespace: biological_process
def: "The chemotaxis process that directs the migration of a photoreceptor cell axon growth cone to its target in the optic lobe in response to a combination of attractive and repulsive cues." [GOC:sart, PMID:20826677]
synonym: "photoreceptor cell axon pathfinding" EXACT [GOC:mah]
is_a: GO:0007411 ! axon guidance
created_by: midori
creation_date: 2010-12-15T05:34:10Z

[Term]
id: GO:0072500
name: obsolete negative regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor
namespace: biological_process
def: "OBSOLETE. Any process in which a ligand-bound hormone receptor acts in the nucleus to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:mah]
comment: This term was made obsolete because it is unclear whether the term represents the action of the receptor or the entire process of transcription regulation. The term 'nuclear hormone receptor' is also misleading since many of these receptors reside in the cytoplasm until they are bound by a ligand.
synonym: "negative regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor" EXACT []
is_obsolete: true
consider: GO:0000122
consider: GO:0004879
consider: GO:0030522
consider: GO:0038049
created_by: midori
creation_date: 2010-12-16T11:47:39Z

[Term]
id: GO:0072501
name: cellular divalent inorganic anion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of divalent inorganic anions at the level of a cell." [GOC:mah]
comment: Note that this term was split from 'cellular di-, tri-valent inorganic anion homeostasis ; GO:0030319' (sibling term 'cellular trivalent inorganic anion homeostasis' ; GO:0072502').
is_a: GO:0030002 ! cellular anion homeostasis
is_a: GO:0072505 ! divalent inorganic anion homeostasis
created_by: midori
creation_date: 2010-12-16T12:53:05Z

[Term]
id: GO:0072502
name: cellular trivalent inorganic anion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of trivalent inorganic anions at the level of a cell." [GOC:mah]
comment: Note that this term was split from 'cellular di-, tri-valent inorganic anion homeostasis ; GO:0030319' (sibling term 'cellular divalent inorganic anion homeostasis' ; GO:0072501').
is_a: GO:0030002 ! cellular anion homeostasis
is_a: GO:0072506 ! trivalent inorganic anion homeostasis
created_by: midori
creation_date: 2010-12-16T12:53:42Z

[Term]
id: GO:0072503
name: cellular divalent inorganic cation homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of divalent cations at the level of a cell." [GOC:mah]
comment: Note that this term was split from 'cellular di-, tri-valent inorganic cation homeostasis ; GO:0030005' (sibling term 'cellular trivalent inorganic cation homeostasis' ; GO:0072504').
subset: gosubset_prok
is_a: GO:0030003 ! cellular cation homeostasis
is_a: GO:0072507 ! divalent inorganic cation homeostasis
created_by: midori
creation_date: 2010-12-16T01:25:40Z

[Term]
id: GO:0072504
name: cellular trivalent inorganic cation homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of trivalent cations at the level of a cell." [GOC:mah]
comment: Note that this term was split from 'cellular di-, tri-valent inorganic cation homeostasis ; GO:0030005' (sibling term 'cellular divalent inorganic cation homeostasis' ; GO:0072503').
subset: gosubset_prok
is_a: GO:0030003 ! cellular cation homeostasis
is_a: GO:0072508 ! trivalent inorganic cation homeostasis
created_by: midori
creation_date: 2010-12-16T01:26:43Z

[Term]
id: GO:0072505
name: divalent inorganic anion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of divalent inorganic anions within an organism or cell." [GOC:mah]
comment: Note that this term was split from 'di-, tri-valent inorganic anion homeostasis ; GO:0055061' (sibling term 'trivalent inorganic anion homeostasis' ; GO:0072506').
is_a: GO:0055081 ! anion homeostasis
is_a: GO:0098771 ! inorganic ion homeostasis
created_by: midori
creation_date: 2010-12-16T01:39:00Z

[Term]
id: GO:0072506
name: trivalent inorganic anion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of trivalent inorganic anions within an organism or cell." [GOC:mah]
comment: Note that this term was split from 'di-, tri-valent inorganic anion homeostasis ; GO:0055061' (sibling term 'divalent inorganic anion homeostasis' ; GO:0072505').
is_a: GO:0055081 ! anion homeostasis
is_a: GO:0098771 ! inorganic ion homeostasis
created_by: midori
creation_date: 2010-12-16T01:39:39Z

[Term]
id: GO:0072507
name: divalent inorganic cation homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of divalent cations within an organism or cell." [GOC:mah]
comment: Note that this term was split from 'di-, tri-valent inorganic cation homeostasis ; GO:0055066' (sibling term 'trivalent inorganic cation homeostasis' ; GO:0072508').
subset: gosubset_prok
is_a: GO:0055080 ! cation homeostasis
is_a: GO:0098771 ! inorganic ion homeostasis
created_by: midori
creation_date: 2010-12-16T03:22:48Z

[Term]
id: GO:0072508
name: trivalent inorganic cation homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of trivalent cations within an organism or cell." [GOC:mah]
comment: Note that this term was split from 'di-, tri-valent inorganic cation homeostasis ; GO:0055066' (sibling term 'divalent inorganic cation homeostasis' ; GO:0072507').
subset: gosubset_prok
is_a: GO:0055080 ! cation homeostasis
is_a: GO:0098771 ! inorganic ion homeostasis
created_by: midori
creation_date: 2010-12-16T03:26:40Z

[Term]
id: GO:0072509
name: divalent inorganic cation transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of inorganic cations with a valency of two from one side of the membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage." [GOC:mah]
subset: gosubset_prok
is_a: GO:0022890 ! inorganic cation transmembrane transporter activity
relationship: part_of GO:0072511 ! divalent inorganic cation transport
created_by: midori
creation_date: 2010-12-16T04:01:36Z

[Term]
id: GO:0072510
name: trivalent inorganic cation transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of inorganic cations with a valency of three from one side of the membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage." [GOC:mah]
subset: gosubset_prok
is_a: GO:0022890 ! inorganic cation transmembrane transporter activity
relationship: part_of GO:0072512 ! trivalent inorganic cation transport
created_by: midori
creation_date: 2010-12-16T04:03:00Z

[Term]
id: GO:0072511
name: divalent inorganic cation transport
namespace: biological_process
def: "The directed movement of inorganic cations with a valency of two into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage." [GOC:mah]
subset: gosubset_prok
is_a: GO:0006812 ! cation transport
created_by: midori
creation_date: 2010-12-16T04:11:02Z

[Term]
id: GO:0072512
name: trivalent inorganic cation transport
namespace: biological_process
def: "The directed movement of inorganic cations with a valency of three into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage." [GOC:mah]
subset: gosubset_prok
is_a: GO:0006812 ! cation transport
created_by: midori
creation_date: 2010-12-16T04:12:40Z

[Term]
id: GO:0072513
name: positive regulation of secondary heart field cardioblast proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardioblast proliferation in the second heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. The secondary heart field is the region of the heart that will form the majority of the mesodermal component of the right ventricle, the arterial pole (outflow tract) and the venous pole (inflow tract)." [GOC:BHF, GOC:mah, GOC:rl]
synonym: "negative regulation of second heart field cardioblast proliferation" EXACT [GOC:mah]
is_a: GO:0003266 ! regulation of secondary heart field cardioblast proliferation
is_a: GO:0008284 ! positive regulation of cell proliferation
created_by: midori
creation_date: 2010-12-17T10:16:43Z

[Term]
id: GO:0072514
name: trehalose transport in response to water deprivation
namespace: biological_process
def: "The directed movement of trehalose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, that occurs as a result of deprivation of water." [GOC:mah]
is_a: GO:0015771 ! trehalose transport
relationship: part_of GO:0042631 ! cellular response to water deprivation
created_by: midori
creation_date: 2010-12-21T11:26:14Z

[Term]
id: GO:0072515
name: trehalose transport in response to desiccation
namespace: biological_process
def: "The directed movement of trehalose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, that occurs as a result of a desiccation stimulus. A desiccation stimulus signals extreme dryness resulting from the prolonged deprivation of water." [GOC:mah]
is_a: GO:0072514 ! trehalose transport in response to water deprivation
relationship: part_of GO:0071465 ! cellular response to desiccation
created_by: midori
creation_date: 2010-12-21T11:30:31Z

[Term]
id: GO:0072516
name: viral assembly compartment
namespace: cellular_component
def: "A membrane-bounded compartment that forms in the cytoplasm of virus-infected cells, in which virus assembly takes place." [GOC:BHF, PMID:20374631]
synonym: "viral assembly site" RELATED [GOC:BHF]
synonym: "virion assembly compartment" EXACT [GOC:mah]
is_a: GO:0043231 ! intracellular membrane-bounded organelle
is_a: GO:0044444 ! cytoplasmic part
created_by: midori
creation_date: 2010-12-21T03:08:42Z

[Term]
id: GO:0072517
name: host cell viral assembly compartment
namespace: cellular_component
def: "A membrane-bounded compartment that forms in the cytoplasm of the host cell, in which virus assembly takes place." [GOC:BHF, PMID:20374631]
synonym: "host cell viral assembly site" RELATED [GOC:BHF]
synonym: "host cell virion assembly compartment" EXACT [GOC:mah]
is_a: GO:0033648 ! host intracellular membrane-bounded organelle
is_a: GO:0039714 ! cytoplasmic viral factory
created_by: midori
creation_date: 2010-12-21T03:14:06Z

[Term]
id: GO:0072518
name: Rho-dependent protein serine/threonine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires binding of the GTPase Rho." [GOC:ecd, PMID:12778124, PMID:20230755]
synonym: "Rho-associated protein kinase activity" EXACT [GOC:ecd]
synonym: "ROCK kinase activity" EXACT [GOC:ecd]
is_a: GO:0004674 ! protein serine/threonine kinase activity
created_by: midori
creation_date: 2010-12-22T11:07:29Z

[Term]
id: GO:0072519
name: parasitism
namespace: biological_process
def: "An interaction between two organisms living together in more or less intimate association in a relationship in which association is disadvantageous or destructive to one of the organisms." [GOC:curators]
is_a: GO:0044403 ! symbiosis, encompassing mutualism through parasitism
created_by: midori
creation_date: 2010-12-30T12:10:35Z

[Term]
id: GO:0072520
name: seminiferous tubule development
namespace: biological_process
def: "The reproductive developmental process whose specific outcome is the progression of the seminiferous tubule over time, from its formation to the mature structure. Seminiferous tubules are ducts located in the testicles, and are the specific location of meiosis, and the subsequent creation of gametes, namely spermatozoa." [GOC:BHF, GOC:mah, UBERON:0001343]
is_a: GO:0035295 ! tube development
is_a: GO:0048608 ! reproductive structure development
relationship: part_of GO:0008584 ! male gonad development
created_by: midori
creation_date: 2011-01-04T12:50:36Z

[Term]
id: GO:0072521
name: purine-containing compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [CHEBI:26401, GOC:mah]
synonym: "purine and derivative metabolic process" EXACT [GOC:curators]
synonym: "purine-containing compound metabolism" EXACT [GOC:mah]
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0034641 ! cellular nitrogen compound metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process
created_by: midori
creation_date: 2011-01-04T03:03:59Z

[Term]
id: GO:0072522
name: purine-containing compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [CHEBI:26401, GOC:mah]
synonym: "purine and derivative biosynthetic process" EXACT [GOC:curators]
synonym: "purine-containing compound anabolism" EXACT [GOC:mah]
synonym: "purine-containing compound biosynthesis" EXACT [GOC:mah]
synonym: "purine-containing compound formation" EXACT [GOC:mah]
synonym: "purine-containing compound synthesis" EXACT [GOC:mah]
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process
is_a: GO:0072521 ! purine-containing compound metabolic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process
created_by: midori
creation_date: 2011-01-04T03:15:29Z

[Term]
id: GO:0072523
name: purine-containing compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [CHEBI:26401, GOC:mah]
synonym: "purine and derivative catabolic process" EXACT [GOC:curators]
synonym: "purine-containing compound breakdown" EXACT [GOC:mah]
synonym: "purine-containing compound catabolism" EXACT [GOC:mah]
synonym: "purine-containing compound degradation" EXACT [GOC:mah]
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0044270 ! cellular nitrogen compound catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:0072521 ! purine-containing compound metabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process
created_by: midori
creation_date: 2011-01-04T03:17:20Z

[Term]
id: GO:0072524
name: pyridine-containing compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof." [CHEBI:26421, GOC:mah]
synonym: "pyridine and derivative metabolic process" EXACT [GOC:curators]
synonym: "pyridine-containing compound metabolism" EXACT [GOC:mah]
is_a: GO:0034641 ! cellular nitrogen compound metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process
created_by: midori
creation_date: 2011-01-04T03:21:47Z

[Term]
id: GO:0072525
name: pyridine-containing compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof." [CHEBI:26421, GOC:mah]
synonym: "pyridine and derivative biosynthetic process" EXACT [GOC:curators]
synonym: "pyridine-containing compound anabolism" EXACT [GOC:mah]
synonym: "pyridine-containing compound biosynthesis" EXACT [GOC:mah]
synonym: "pyridine-containing compound formation" EXACT [GOC:mah]
synonym: "pyridine-containing compound synthesis" EXACT [GOC:mah]
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process
is_a: GO:0072524 ! pyridine-containing compound metabolic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process
created_by: midori
creation_date: 2011-01-04T03:23:01Z

[Term]
id: GO:0072526
name: pyridine-containing compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof." [CHEBI:26421, GOC:mah]
synonym: "pyridine and derivative catabolic process" EXACT [GOC:curators]
synonym: "pyridine-containing compound breakdown" EXACT [GOC:mah]
synonym: "pyridine-containing compound catabolism" EXACT [GOC:mah]
synonym: "pyridine-containing compound degradation" EXACT [GOC:mah]
is_a: GO:0044270 ! cellular nitrogen compound catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:0072524 ! pyridine-containing compound metabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process
created_by: midori
creation_date: 2011-01-04T03:23:14Z

[Term]
id: GO:0072527
name: pyrimidine-containing compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof." [CHEBI:39447, GOC:mah]
synonym: "pyrimidine and derivative metabolic process" EXACT [GOC:curators]
synonym: "pyrimidine-containing compound metabolism" EXACT [GOC:mah]
is_a: GO:0034641 ! cellular nitrogen compound metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process
created_by: midori
creation_date: 2011-01-04T03:27:19Z

[Term]
id: GO:0072528
name: pyrimidine-containing compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof." [CHEBI:39447, GOC:mah]
synonym: "pyrimidine and derivative biosynthetic process" EXACT [GOC:curators]
synonym: "pyrimidine-containing compound anabolism" EXACT [GOC:mah]
synonym: "pyrimidine-containing compound biosynthesis" EXACT [GOC:mah]
synonym: "pyrimidine-containing compound formation" EXACT [GOC:mah]
synonym: "pyrimidine-containing compound synthesis" EXACT [GOC:mah]
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process
is_a: GO:0072527 ! pyrimidine-containing compound metabolic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process
created_by: midori
creation_date: 2011-01-04T03:27:36Z

[Term]
id: GO:0072529
name: pyrimidine-containing compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof." [CHEBI:39447, GOC:mah]
synonym: "pyrimidine and derivative catabolic process" EXACT [GOC:curators]
synonym: "pyrimidine-containing compound breakdown" EXACT [GOC:mah]
synonym: "pyrimidine-containing compound catabolism" EXACT [GOC:mah]
synonym: "pyrimidine-containing compound degradation" EXACT [GOC:mah]
is_a: GO:0044270 ! cellular nitrogen compound catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:0072527 ! pyrimidine-containing compound metabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process
created_by: midori
creation_date: 2011-01-04T03:27:51Z

[Term]
id: GO:0072530
name: purine-containing compound transmembrane transport
namespace: biological_process
def: "The directed movement of a purine-containing compound across a membrane. A purine-containing compound is any compound that contains purine or a formal derivative thereof." [CHEBI:26401, GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "purine-containing compound membrane transport" EXACT []
is_a: GO:0055085 ! transmembrane transport
is_a: GO:0071702 ! organic substance transport
is_a: GO:0071705 ! nitrogen compound transport
created_by: midori
creation_date: 2011-01-05T01:45:14Z

[Term]
id: GO:0072531
name: pyrimidine-containing compound transmembrane transport
namespace: biological_process
def: "The directed movement of a pyrimidine-containing compound across a membrane. A pyrimidine-containing compound is any compound that contains pyrimidine or a formal derivative thereof." [CHEBI:39447, GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "pyrimidine-containing compound membrane transport" EXACT []
is_a: GO:0055085 ! transmembrane transport
is_a: GO:0071702 ! organic substance transport
is_a: GO:0071705 ! nitrogen compound transport
created_by: midori
creation_date: 2011-01-05T01:47:22Z

[Term]
id: GO:0072532
name: tri-(feruloyl or hydroxyferuloyl) spermidine meta-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the meta-hydroxylation of any of the three phenolic rings on triferuloyl spermidine or any of its mono- or di-(hydroxyferuloyl)-spermidine derivatives." [GOC:kad, PMID:19779199]
comment: Note that the overall reaction representing three successive executions of this activity is N1,N5,N10-triferuloyl spermidine + 3 NADPH + 3 O2 = N1,N5,N10-tri-(hydroxyferuloyl)-spermidine + 3 NADP+ + 3 H2O; this corresponds to the MetaCyc reaction RXN-11262 (http://biocyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-11262) and the KEGG reaction R08986 (http://www.genome.jp/dbget-bin/www_bget?rn:R08986).
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
created_by: midori
creation_date: 2011-01-12T01:54:31Z

[Term]
id: GO:0072533
name: tri-(coumaroyl or caffeoyl) spermidine meta-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the meta-hydroxylation of any of the three phenolic rings on tricoumaroyl spermidine or any of its mono- or dicaffeoyl spermidine derivatives." [GOC:kad, PMID:19779199]
comment: Note that the overall reaction representing three successive executions of this activity is N1,N5,N10-tricoumaroyl spermidine + 3 NADPH + 3 O2 = N1,N5,N10-tricaffeoyl spermidine + 3 NADP+ + 3 H2O; this corresponds to the MetaCyc reaction RXN-11260 (http://biocyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-11260).
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
created_by: midori
creation_date: 2011-01-12T02:03:07Z

[Term]
id: GO:0072534
name: perineuronal net
namespace: cellular_component
def: "A dense extracellular matrix (ECM) structure that forms around many neuronal cell bodies and dendrites late in development and is responsible for synaptic stabilization in the adult brain." [GOC:sl, PMID:18364019]
synonym: "PNN" EXACT [GOC:sl]
is_a: GO:0044420 ! extracellular matrix component
created_by: midori
creation_date: 2011-01-14T01:37:40Z

[Term]
id: GO:0072535
name: tumor necrosis factor (ligand) superfamily member 11 production
namespace: biological_process
def: "The appearance of tumor necrosis factor superfamily member 11 (TNFSF11; RANKL) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah]
synonym: "RANKL production" EXACT [GOC:ebc, PR:000002107]
synonym: "TNFSF11 production" EXACT [GOC:mah, PR:000002107]
synonym: "tumor necrosis factor ligand superfamily member 11 production" EXACT [GOC:bf, PR:000002107]
is_a: GO:0071706 ! tumor necrosis factor superfamily cytokine production
created_by: midori
creation_date: 2011-01-14T01:42:23Z

[Term]
id: GO:0072536
name: interleukin-23 receptor complex
namespace: cellular_component
def: "A protein complex that binds interleukin-23. The complex comprises two subunits, including the same beta subunit found in the interleukin-12 receptor." [GOC:BHF, GOC:mah, PMID:12023369]
synonym: "IL-23 receptor complex" EXACT [GOC:mah]
is_a: GO:0098802 ! plasma membrane receptor complex
relationship: part_of GO:0005887 ! integral component of plasma membrane
created_by: midori
creation_date: 2011-01-14T02:51:14Z

[Term]
id: GO:0072537
name: fibroblast activation
namespace: biological_process
def: "A change in the morphology or behavior of a fibroblast resulting from exposure to an activating factor such as a cellular or soluble ligand." [CL:0000057, GOC:BHF, GOC:mah]
is_a: GO:0001775 ! cell activation
created_by: midori
creation_date: 2011-01-14T04:35:08Z

[Term]
id: GO:0072538
name: T-helper 17 type immune response
namespace: biological_process
def: "An immune response which is associated with resistance to intracellular bacteria with a key role in inflammation and tissue injury. This immune response is associated with pathological autoimmune conditions such as multiple sclerosis, arthritis and psoriasis which is typically orchestrated by the production of particular cytokines by T-helper 17 cells, most notably interleukin-17, IL-21 and IL-22." [GOC:BHF, GOC:ebc]
synonym: "Th17 immune response" EXACT [GOC:mah]
is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
created_by: midori
creation_date: 2011-01-17T11:13:53Z

[Term]
id: GO:0072539
name: T-helper 17 cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 17 (Th17) cell. A Th17 cell is a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17." [CL:0000899, GOC:BHF, GOC:ebc]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "T-helper 17 cell development" RELATED [GOC:mah]
is_a: GO:0042093 ! T-helper cell differentiation
relationship: part_of GO:0072538 ! T-helper 17 type immune response
created_by: midori
creation_date: 2011-01-17T11:18:47Z

[Term]
id: GO:0072540
name: T-helper 17 cell lineage commitment
namespace: biological_process
def: "The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 17 cell, a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17." [CL:0000899, GOC:BHF, GOC:ebc]
synonym: "T-helper 17 cell fate commitment" EXACT [GOC:mah]
synonym: "Th17 cell lineage commitment" EXACT [CL:0000899, GOC:mah]
synonym: "Th17 fate commitment" EXACT [CL:0000899]
is_a: GO:0002295 ! T-helper cell lineage commitment
relationship: part_of GO:0072539 ! T-helper 17 cell differentiation
created_by: midori
creation_date: 2011-01-17T11:19:48Z

[Term]
id: GO:0072541
name: peroxynitrite reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 R-SH + ONOO- = R-SS-R + NO2- + H2O." [GOC:rs, PMID:11001062]
comment: Note that this activity is usually associated in vivo with an NADPH-dependent disulfide reductase activity, so that catalysis of the reduction of peroxynitrite to nitrite involves the possible creation of oxygen or water, using NADPH as reduction equivalent.
synonym: "peroxynitritase activity" EXACT [GOC:rs]
is_a: GO:0051920 ! peroxiredoxin activity
created_by: midori
creation_date: 2011-01-17T11:43:37Z

[Term]
id: GO:0072542
name: protein phosphatase activator activity
namespace: molecular_function
def: "Increases the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule." [GOC:mah]
is_a: GO:0019211 ! phosphatase activator activity
is_a: GO:0019888 ! protein phosphatase regulator activity
created_by: midori
creation_date: 2011-01-17T01:21:31Z

[Term]
id: GO:0072543
name: protein phosphatase type 2A activator activity
namespace: molecular_function
def: "Increases the activity of the enzyme protein phosphatase type 2A." [GOC:vw]
synonym: "protein phosphatase 2 activator activity" RELATED [GOC:dph, GOC:rl]
is_a: GO:0008601 ! protein phosphatase type 2A regulator activity
is_a: GO:0072542 ! protein phosphatase activator activity
relationship: part_of GO:0034049 ! positive regulation of protein phosphatase type 2A activity
created_by: midori
creation_date: 2011-01-17T01:36:31Z

[Term]
id: GO:0072544
name: L-DOPA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with L-DOPA, the modified amino acid (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid." [CHEBI:15765, GOC:mah, GOC:vw]
synonym: "L-dopa binding" EXACT [CHEBI:15765]
is_a: GO:0016597 ! amino acid binding
is_a: GO:0072341 ! modified amino acid binding
created_by: midori
creation_date: 2011-01-19T05:40:04Z

[Term]
id: GO:0072545
name: tyrosine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with2-amino-3-(4-hydroxyphenyl)propanoic acid." [CHEBI:18186, GOC:mah]
synonym: "Tyr binding" EXACT [GOC:mah]
is_a: GO:0016597 ! amino acid binding
is_a: GO:0043169 ! cation binding
is_a: GO:0097159 ! organic cyclic compound binding
created_by: midori
creation_date: 2011-01-19T05:43:55Z

[Term]
id: GO:0072546
name: ER membrane protein complex
namespace: cellular_component
def: "A transmembrane protein complex that is involved in protein folding in the endoplasmic reticulum. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6." [GOC:dgf, PMID:19325107]
synonym: "EMC" EXACT []
synonym: "endoplasmic reticulum membrane protein complex" EXACT [GOC:mah]
is_a: GO:0044432 ! endoplasmic reticulum part
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0030176 ! integral component of endoplasmic reticulum membrane
created_by: midori
creation_date: 2011-01-19T06:16:53Z

[Term]
id: GO:0072547
name: tricoumaroylspermidine meta-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: tricoumaroyl spermidine + NADPH + O2 = dicoumaroyl monocaffeoyl spermidine + NADP+ + H2O." [GOC:kad, PMID:19779199]
synonym: "tricoumaroyl spermidine meta-hydroxylase activity" EXACT [GOC:mah]
is_a: GO:0072533 ! tri-(coumaroyl or caffeoyl) spermidine meta-hydroxylase activity
created_by: midori
creation_date: 2011-01-25T02:49:37Z

[Term]
id: GO:0072548
name: dicoumaroyl monocaffeoyl spermidine meta-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: dicoumaroyl monocaffeoyl spermidine + NADPH + O2 = monocoumaroyl dicaffeoyl spermidine + NADP+ + H2O." [GOC:kad, PMID:19779199]
is_a: GO:0072533 ! tri-(coumaroyl or caffeoyl) spermidine meta-hydroxylase activity
created_by: midori
creation_date: 2011-01-25T02:57:22Z

[Term]
id: GO:0072549
name: monocoumaroyl dicaffeoyl spermidine meta-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: monocoumaroyl dicaffeoyl spermidine + NADPH + O2 = tricaffeoyl spermidine + NADP+ + H2O." [GOC:kad, PMID:19779199]
is_a: GO:0072533 ! tri-(coumaroyl or caffeoyl) spermidine meta-hydroxylase activity
created_by: midori
creation_date: 2011-01-25T02:58:04Z

[Term]
id: GO:0072550
name: triferuloylspermidine meta-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: triferuloyl spermidine + NADPH + O2 = diferuloyl mono-(hydroxyferuloyl) spermidine + NADP+ + H2O." [GOC:kad, PMID:19779199]
synonym: "triferuloyl spermidine meta-hydroxylase activity" EXACT [GOC:mah]
is_a: GO:0072532 ! tri-(feruloyl or hydroxyferuloyl) spermidine meta-hydroxylase activity
created_by: midori
creation_date: 2011-01-25T02:58:56Z

[Term]
id: GO:0072551
name: diferuloyl mono-(hydroxyferuloyl) spermidine meta-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: diferuloyl mono-(hydroxyferuloyl) spermidine + NADPH + O2 = monoferuloyl di-(hydroxyferuloyl) spermidine + NADP+ + H2O." [GOC:kad, PMID:19779199]
is_a: GO:0072532 ! tri-(feruloyl or hydroxyferuloyl) spermidine meta-hydroxylase activity
created_by: midori
creation_date: 2011-01-25T03:04:16Z

[Term]
id: GO:0072552
name: monoferuloyl di-(hydroxyferuloyl) spermidine meta-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: monoferuloyl di-(hydroxyferuloyl) spermidine + NADPH + O2 = tri-(hydroxyferuloyl) spermidine + NADP+ + H2O." [GOC:kad, PMID:19779199]
is_a: GO:0072532 ! tri-(feruloyl or hydroxyferuloyl) spermidine meta-hydroxylase activity
created_by: midori
creation_date: 2011-01-25T03:15:31Z

[Term]
id: GO:0072553
name: terminal button organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a terminal button. A terminal button is the terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters." [GOC:BHF, GOC:mah]
synonym: "bouton organization" EXACT [GOC:mah]
synonym: "presynaptic bouton organization" EXACT [GOC:mah]
synonym: "synaptic bouton organization" EXACT [GOC:mah]
synonym: "terminal bouton organization" EXACT [GOC:mah]
synonym: "terminal button organisation" EXACT [GOC:mah]
is_a: GO:0016043 ! cellular component organization
is_a: GO:0044763 ! single-organism cellular process
relationship: part_of GO:0050808 ! synapse organization
created_by: midori
creation_date: 2011-01-25T04:09:35Z

[Term]
id: GO:0072554
name: blood vessel lumenization
namespace: biological_process
def: "The process in which a developing blood vessel forms an endothelial lumen through which blood will flow." [GOC:dsf, PMID:16799567, PMID:20926893]
is_a: GO:0061154 ! endothelial tube morphogenesis
relationship: part_of GO:0048514 ! blood vessel morphogenesis
created_by: midori
creation_date: 2011-01-25T05:19:30Z

[Term]
id: GO:0072555
name: 17-beta-ketosteroid reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 17-beta-ketosteroid + NADPH + H+ = a 17-beta-hydroxysteroid + NADP+." [GOC:kad, PMID:17074428]
synonym: "17-beta-ketosteroid reductase (NADPH) activity" EXACT [GOC:kad]
synonym: "7beta-ketosteroid reductase activity" EXACT [GOC:kad]
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
created_by: midori
creation_date: 2011-01-27T11:36:14Z

[Term]
id: GO:0072556
name: other organism presynaptic membrane
namespace: cellular_component
def: "A presynaptic membrane that is part of another organism, i.e. a secondary organism with which the first organism is interacting. A presynaptic membrane is specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane." [GOC:mah]
synonym: "other organism pre-synaptic membrane" EXACT []
is_a: GO:0044218 ! other organism cell membrane
created_by: midori
creation_date: 2011-01-27T11:47:45Z

[Term]
id: GO:0072557
name: IPAF inflammasome complex
namespace: cellular_component
def: "A protein complex that consists of three components, IPAF, NAIP and caspase-1, and includes among its functions the sensing of flagellin derived from Legionella pneumophila, Salmonella typhimurium, Pseudomonas aeruginosa and Shigella flexneri." [GOC:add, GOC:BHF, GOC:vp, PMID:20303873]
is_a: GO:0061702 ! inflammasome complex
created_by: midori
creation_date: 2011-01-27T12:01:44Z

[Term]
id: GO:0072558
name: NLRP1 inflammasome complex
namespace: cellular_component
def: "A protein complex that consists of two components, NLRP1 (NALP1) and caspase-1 or caspase-5. The exact mechanisms of NLRP1 activation remain obscure, but potassium ion efflux appears to be essential." [GOC:add, GOC:BHF, GOC:vp, PMID:20303873]
synonym: "NALP1 inflammasome complex" EXACT []
is_a: GO:0061702 ! inflammasome complex
created_by: midori
creation_date: 2011-01-27T12:03:50Z

[Term]
id: GO:0072559
name: NLRP3 inflammasome complex
namespace: cellular_component
def: "A protein complex that consists of three components, NLRP3 (NALP3), PYCARD and caspase-1. It is activated upon exposure to whole pathogens, as well as a number of structurally diverse pathogen- and danger-associated molecular patterns (PAMPs and DAMPs) and environmental irritants. Whole pathogens demonstrated to activate the NLRP3 inflammasome complex include the fungi Candida albicans and Saccharomyces cerevisiae, bacteria that produce pore-forming toxins, including Listeria monocytogenes and Staphylococcus aureus, and viruses such as Sendai virus, adenovirus, and influenza virus." [GOC:add, GOC:BHF, GOC:vp, PMID:20303873]
synonym: "NALP3 inflammasome complex" EXACT []
is_a: GO:0061702 ! inflammasome complex
created_by: midori
creation_date: 2011-01-27T12:04:30Z

[Term]
id: GO:0072560
name: type B pancreatic cell maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a type B pancreatic cell to attain its fully functional state. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:BHF]
comment: These processes continue to 60 DPA in Gossypium spp.
synonym: "pancreatic B cell maturation" EXACT [CL:0000169, GOC:mah]
synonym: "pancreatic beta cell maturation" EXACT [CL:0000169, GOC:mah]
is_a: GO:0002071 ! glandular epithelial cell maturation
relationship: part_of GO:0003323 ! type B pancreatic cell development
created_by: midori
creation_date: 2011-01-27T01:57:14Z

[Term]
id: GO:0072562
name: blood microparticle
namespace: cellular_component
def: "A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids." [GOC:BHF, GOC:mah, PMID:16373184]
synonym: "cell membrane microparticle" EXACT [PMID:16373184]
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005615 ! extracellular space
created_by: midori
creation_date: 2011-01-28T11:50:56Z

[Term]
id: GO:0072563
name: endothelial microparticle
namespace: cellular_component
def: "A blood microparticle that is derived from, and contains membrane receptors as well as other proteins characteristic of, an endothelial cell." [GOC:BHF, GOC:mah, PMID:16373184]
is_a: GO:0072562 ! blood microparticle
created_by: midori
creation_date: 2011-01-28T01:53:25Z

[Term]
id: GO:0072564
name: blood microparticle formation
namespace: biological_process
def: "The cellular component organization process in which microparticles bud off from a parent cell. A microparticle is a phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell." [GOC:BHF, GOC:mah, PMID:16373184]
synonym: "microparticle generation" EXACT [PMID:20978343]
synonym: "microparticle release" EXACT [PMID:16373184]
is_a: GO:0016043 ! cellular component organization
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
created_by: midori
creation_date: 2011-01-28T02:15:50Z

[Term]
id: GO:0072565
name: endothelial microparticle formation
namespace: biological_process
def: "The cellular component organization process in which microparticles bud off from an endothelial cell." [GOC:BHF, GOC:mah, PMID:16373184]
synonym: "endothelial microparticle generation" EXACT [GOC:mah, PMID:20978343]
synonym: "endothelial microparticle release" EXACT [GOC:mah, PMID:16373184]
is_a: GO:0072564 ! blood microparticle formation
created_by: midori
creation_date: 2011-01-28T02:21:58Z

[Term]
id: GO:0072566
name: chemokine (C-X-C motif) ligand 1 production
namespace: biological_process
def: "The appearance of chemokine (C-X-C motif) ligand 1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah]
synonym: "CXCL1 production" EXACT [GOC:BHF]
synonym: "KC production" EXACT [GOC:BHF]
synonym: "keratinocyte derived chemokine production" EXACT [GOC:BHF]
synonym: "SCYB1 production" EXACT [GOC:BHF]
is_a: GO:0032602 ! chemokine production
created_by: midori
creation_date: 2011-01-31T11:31:58Z

[Term]
id: GO:0072567
name: chemokine (C-X-C motif) ligand 2 production
namespace: biological_process
def: "The appearance of chemokine (C-X-C motif) ligand 2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah]
synonym: "CXCL2 production" EXACT [GOC:mah]
synonym: "MIP-2 production" EXACT [GOC:BHF]
synonym: "MIP2 production" EXACT [GOC:BHF]
synonym: "SCYB2 production" EXACT [GOC:BHF]
is_a: GO:0032602 ! chemokine production
created_by: midori
creation_date: 2011-01-31T11:33:40Z

[Term]
id: GO:0072570
name: ADP-D-ribose binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with ADP-D-ribose, an ADP-aldose having ribose as the aldose fragment." [CHEBI:16864, GOC:mah, GOC:sart, PMID:20088964]
synonym: "ADP-ribose binding" BROAD [GOC:mah]
is_a: GO:0000166 ! nucleotide binding
is_a: GO:0043168 ! anion binding
is_a: GO:0097367 ! carbohydrate derivative binding
created_by: midori
creation_date: 2011-01-31T02:37:30Z

[Term]
id: GO:0072571
name: mono-ADP-D-ribose binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with monomeric ADP-D-ribose, an ADP-aldose having ribose as the aldose fragment." [CHEBI:16864, GOC:mah, GOC:sart, PMID:20088964]
synonym: "mADPr binding" EXACT [PMID:20088964]
synonym: "mono-ADP-ribose binding" BROAD [GOC:mah]
is_a: GO:0072570 ! ADP-D-ribose binding
created_by: midori
creation_date: 2011-01-31T02:39:12Z

[Term]
id: GO:0072572
name: poly-ADP-D-ribose binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with polymeric ADP-D-ribose, a polymer that is composed of poly-ADP-D-ribose units linked through 1,2-glycosidic bonds at the ribose ring." [CHEBI:61151, GOC:mah, GOC:sart, PMID:20088964]
synonym: "pADPr binding" EXACT [PMID:20088964]
synonym: "poly-ADP-ribose binding" BROAD [GOC:mah]
is_a: GO:0097367 ! carbohydrate derivative binding
created_by: midori
creation_date: 2011-01-31T02:49:04Z

[Term]
id: GO:0072573
name: tolerance induction to lipopolysaccharide
namespace: biological_process
def: "Tolerance induction directed at lipopolysaccharide antigens." [GOC:BHF, GOC:mah]
synonym: "tolerance induction to endotoxin" BROAD [GOC:add, GOC:mah]
synonym: "tolerance induction to LPS" EXACT [GOC:add, GOC:mah]
is_a: GO:0002507 ! tolerance induction
is_a: GO:0031665 ! negative regulation of lipopolysaccharide-mediated signaling pathway
relationship: part_of GO:0071222 ! cellular response to lipopolysaccharide
created_by: midori
creation_date: 2011-02-02T03:05:19Z

[Term]
id: GO:0072574
name: hepatocyte proliferation
namespace: biological_process
def: "The multiplication or reproduction of hepatocytes, resulting in the expansion of a cell population. Hepatocytes form the main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules." [CL:0000182, GOC:BHF, GOC:mah]
is_a: GO:0072575 ! epithelial cell proliferation involved in liver morphogenesis
created_by: midori
creation_date: 2011-02-02T03:34:49Z

[Term]
id: GO:0072575
name: epithelial cell proliferation involved in liver morphogenesis
namespace: biological_process
def: "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the liver." [GOC:BHF, GOC:mah]
is_a: GO:0050673 ! epithelial cell proliferation
intersection_of: GO:0050673 ! epithelial cell proliferation
intersection_of: part_of GO:0072576 ! liver morphogenesis
relationship: part_of GO:0072576 ! liver morphogenesis
created_by: midori
creation_date: 2011-02-02T03:37:50Z

[Term]
id: GO:0072576
name: liver morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the liver are generated and organized." [GOC:mah]
is_a: GO:0022612 ! gland morphogenesis
relationship: part_of GO:0001889 ! liver development
created_by: midori
creation_date: 2011-02-02T03:41:30Z

[Term]
id: GO:0072577
name: endothelial cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in an endothelial cell. An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal." [CL:0000115, GOC:BHF, GOC:mah, GOC:mtg_apoptosis]
synonym: "apoptosis of endothelial cells" EXACT [GOC:mah]
synonym: "endothelial cell apoptosis" NARROW []
synonym: "endothelial cell programmed cell death by apoptosis" EXACT [GOC:mah]
synonym: "killing of endothelial cells" EXACT [GOC:mah]
synonym: "programmed cell death of endothelial cells by apoptosis" EXACT [GOC:mah]
synonym: "programmed cell death, endothelial cells" EXACT [GOC:mah]
is_a: GO:1904019 ! epithelial cell apoptotic process
created_by: midori
creation_date: 2011-02-02T03:56:24Z

[Term]
id: GO:0072578
name: neurotransmitter-gated ion channel clustering
namespace: biological_process
def: "The receptor clustering process in which neurotransmitter-gated ion channels are localized to distinct domains in the cell membrane." [GOC:dsf, PMID:20843816]
is_a: GO:0043113 ! receptor clustering
relationship: part_of GO:0050808 ! synapse organization
created_by: midori
creation_date: 2011-02-03T01:45:48Z

[Term]
id: GO:0072579
name: glycine receptor clustering
namespace: biological_process
def: "The receptor clustering process in which glycine receptors are localized to distinct domains in the cell membrane." [GOC:dsf, GOC:mah, GOC:pr, PMID:20843816]
is_a: GO:0072578 ! neurotransmitter-gated ion channel clustering
relationship: part_of GO:0001941 ! postsynaptic membrane organization
created_by: midori
creation_date: 2011-02-03T01:47:40Z

[Term]
id: GO:0072580
name: bacterial-type EF-P lysine modification
namespace: biological_process
def: "The modification of a lysine residue in a protein to produce (2S)-2-amino-6-([(3S)-3,6-diaminohexanoyl]amino)hexanoic acid, and the subsequent hydroxylation of the modified lysine residue. This modification is observed in, and is probably unique to, the prokaryotic translation elongation factor P (EF-P)." [GOC:curators, GOC:imk, GOC:mah, PMID:20729861, PMID:22706199, RESID:AA0530, RESID:AA0531]
comment: The EF-P modification pathway is now thought to be composed of three steps: conversion of alpha-lysyl-EF-P to beta-lysyl-EF-P, lysylation of Lys34, and hydroxylation of Lys34.
synonym: "EF-P modification pathway" EXACT [PMID:22706199]
is_a: GO:0018205 ! peptidyl-lysine modification
created_by: midori
creation_date: 2011-02-07T11:47:33Z

[Term]
id: GO:0072581
name: protein-N6-(L-lysyl)-L-lysine modification to protein-N6-(beta-lysyl)-L-lysine
namespace: biological_process
def: "The modification of an N6-(lysyl)-L-lysine residue in a protein, producing protein-N6-(beta-lysyl)-L-lysine ((2S)-2-amino-6-([(2S)-2,6-diaminohexanoyl]amino)hexanoic acid). This modification is observed in, and is probably unique to, translation elongation factor P (EF-P)." [GOC:jsg, GOC:mah, PMID:20729861, RESID:AA0531]
is_a: GO:0018205 ! peptidyl-lysine modification
relationship: part_of GO:0072580 ! bacterial-type EF-P lysine modification
created_by: midori
creation_date: 2011-02-07T11:51:02Z

[Term]
id: GO:0072582
name: 17-beta-hydroxysteroid dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: a 17-beta-hydroxysteroid + NADP+ = a 17-oxosteroid + NADPH + H+." [GOC:kad, PMID:17074428]
xref: RHEA:24619
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
created_by: midori
creation_date: 2011-02-07T01:54:21Z

[Term]
id: GO:0072583
name: clathrin-mediated endocytosis
namespace: biological_process
def: "An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles." [GOC:BHF, GOC:mah, PMID:18498251, PMID:8970738, PMID:9234965]
synonym: "clathrin coated pit-dependent endocytosis" EXACT [GOC:BHF]
synonym: "clathrin-dependent endocytosis" EXACT [GOC:mah]
is_a: GO:0006898 ! receptor-mediated endocytosis
created_by: midori
creation_date: 2011-02-08T03:59:18Z

[Term]
id: GO:0072584
name: caveolin-mediated endocytosis
namespace: biological_process
def: "An endocytosis process that begins when material is taken up into plasma membrane caveolae, which then pinch off to form endocytic caveolar carriers." [GOC:BHF, GOC:mah, PMID:17318224, PMID:18498251, PMID:8970738, PMID:9234965]
synonym: "caveolae-dependent endocytosis" EXACT [GOC:mah]
synonym: "caveolae-mediated endocytosis" EXACT [GOC:mah]
synonym: "caveolin-dependent endocytosis" EXACT [GOC:BHF]
is_a: GO:0006898 ! receptor-mediated endocytosis
created_by: midori
creation_date: 2011-02-08T04:08:33Z

[Term]
id: GO:0072585
name: xanthosine nucleotidase activity
namespace: molecular_function
def: "Catalysis of the reaction: xanthosine + H2O = D-ribose + xanthine." [GOC:kad, MetaCyc:RXN0-363, PMID:21235647]
synonym: "xanthosine ribohydrolase activity" EXACT [GOC:kad]
xref: MetaCyc:RXN0-363
is_a: GO:0008477 ! purine nucleosidase activity
created_by: midori
creation_date: 2011-02-08T04:38:31Z

[Term]
id: GO:0072586
name: DNA topoisomerase (ATP-hydrolyzing) regulator activity
namespace: molecular_function
def: "Modulates the activity of ATP-hydrolyzing DNA topoisomerase. DNA topoisomerase (ATP-hydrolyzing) regulator activity catalyzes a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2." [GOC:mah]
is_a: GO:0060590 ! ATPase regulator activity
relationship: part_of GO:2000371 ! regulation of DNA topoisomerase (ATP-hydrolyzing) activity
relationship: regulates GO:0003918 ! DNA topoisomerase type II (ATP-hydrolyzing) activity
created_by: midori
creation_date: 2011-02-09T05:31:50Z

[Term]
id: GO:0072587
name: DNA topoisomerase (ATP-hydrolyzing) activator activity
namespace: molecular_function
def: "Binds to and increases the activity of ATP-hydrolyzing DNA topoisomerase. DNA topoisomerase (ATP-hydrolyzing) regulator activity catalyzes a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2." [GOC:mah]
is_a: GO:0001671 ! ATPase activator activity
is_a: GO:0072586 ! DNA topoisomerase (ATP-hydrolyzing) regulator activity
relationship: part_of GO:2000373 ! positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
relationship: positively_regulates GO:0003918 ! DNA topoisomerase type II (ATP-hydrolyzing) activity
created_by: midori
creation_date: 2011-02-09T05:34:47Z

[Term]
id: GO:0072588
name: box H/ACA RNP complex
namespace: cellular_component
def: "A ribonucleoprotein complex that contains an RNA of the box H/ACA type and the four core proteins dyskerin, NOP10, NHP2, and GAR1 (human protein nomenclature). RNA pseudouridylation (isomerization of uridine to pseudouridine) is the major, and most likely the ancestral, function of H/ACA RNPs. Pseudouridylation targets include both large and small ribosomal RNAs (rRNAs), and small nuclear RNA (U2 snRNA). In addition to these catalytic H/ACA RNPs, a less abundant but more diverse class of structural H/ACA RNPs exists, which does not have pseudouridylation activity. These include the vertebrate telomerase RNP complex." [GOC:BHF, GOC:BHF_telomerase, GOC:jbu, GOC:mah, GOC:vw, PMID:17284456, PMID:20227365]
synonym: "box H/ACA snoRNP pseudouridylase complex" RELATED [GOC:mah]
synonym: "sRNP complex" NARROW [GOC:mah, PMID:17284456, PMID:20227365]
is_a: GO:0005732 ! small nucleolar ribonucleoprotein complex
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0005697 ! telomerase holoenzyme complex
created_by: midori
creation_date: 2011-02-10T01:43:37Z

[Term]
id: GO:0072589
name: box H/ACA scaRNP complex
namespace: cellular_component
def: "A box H/ACA RNP complex that is located in the Cajal body of the nucleoplasm. In higher eukaryotes, box H/ACA RNP located in Cajal bodies mediate pseudouridylation of spliceosomal snRNAs." [GOC:mah, PMID:17284456, PMID:20227365]
synonym: "nucleoplasmic box H/ACA RNP pseudouridylase complex" EXACT [GOC:mah, GOC:vw, PMID:20227365]
is_a: GO:0044451 ! nucleoplasm part
is_a: GO:0072588 ! box H/ACA RNP complex
relationship: part_of GO:0015030 ! Cajal body
created_by: midori
creation_date: 2011-02-10T02:47:17Z

[Term]
id: GO:0072590
name: N-acetyl-L-aspartate-L-glutamate ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + N-acetyl-L-aspartate + L-glutamate = ADP + phosphate + N-acetylaspartyl-glutamate." [PMID:20643647, PMID:20657015]
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds
created_by: midori
creation_date: 2011-02-10T03:20:41Z

[Term]
id: GO:0072591
name: citrate-L-glutamate ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + citrate + L-glutamate = ADP + phosphate + beta-citryl-L-glutamate." [PMID:20657015]
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds
created_by: midori
creation_date: 2011-02-10T03:24:26Z

[Term]
id: GO:0072592
name: oxygen metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving diatomic oxygen (O2)." [CHEBI:33263, GOC:mah]
synonym: "diatomic oxygen metabolic process" EXACT [CHEBI:33263]
synonym: "oxygen metabolism" EXACT [GOC:mah]
is_a: GO:0044237 ! cellular metabolic process
created_by: midori
creation_date: 2011-02-11T10:46:51Z

[Term]
id: GO:0072593
name: reactive oxygen species metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers." [CHEBI:26523, GOC:mah]
synonym: "reactive oxygen species metabolism" EXACT [GOC:mah]
synonym: "ROS metabolic process" EXACT [CHEBI:26523, GOC:mah]
is_a: GO:0044237 ! cellular metabolic process
created_by: midori
creation_date: 2011-02-11T10:50:06Z

[Term]
id: GO:0072594
name: establishment of protein localization to organelle
namespace: biological_process
def: "The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle." [GOC:mah]
synonym: "establishment of protein localisation to organelle" EXACT [GOC:mah]
is_a: GO:0045184 ! establishment of protein localization
relationship: part_of GO:0033365 ! protein localization to organelle
created_by: midori
creation_date: 2011-02-14T01:56:51Z

[Term]
id: GO:0072595
name: maintenance of protein localization in organelle
namespace: biological_process
def: "Any process in which a protein is maintained in a specific location a specific location on or in an organelle, and is prevented from moving elsewhere. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle." [GOC:mah]
synonym: "maintenance of protein localisation to organelle" EXACT [GOC:mah]
synonym: "maintenance of protein localization to organelle" EXACT [GOC:curators]
is_a: GO:0032507 ! maintenance of protein location in cell
intersection_of: GO:0045185 ! maintenance of protein location
intersection_of: occurs_in GO:0043226 ! organelle
relationship: occurs_in GO:0043226 ! organelle
relationship: part_of GO:0033365 ! protein localization to organelle
created_by: midori
creation_date: 2011-02-14T02:09:13Z

[Term]
id: GO:0072596
name: establishment of protein localization to chloroplast
namespace: biological_process
def: "The directed movement of a protein to a specific location in a chloroplast." [GOC:mah]
synonym: "establishment of protein localisation to chloroplast" EXACT [GOC:mah]
is_a: GO:0072594 ! establishment of protein localization to organelle
relationship: part_of GO:0072598 ! protein localization to chloroplast
created_by: midori
creation_date: 2011-02-14T02:16:13Z

[Term]
id: GO:0072597
name: maintenance of protein location in chloroplast
namespace: biological_process
def: "Any process in which a protein is maintained in a specific location in a chloroplast, and is prevented from moving elsewhere." [GOC:mah]
is_a: GO:0051220 ! cytoplasmic sequestering of protein
is_a: GO:0072595 ! maintenance of protein localization in organelle
intersection_of: GO:0045185 ! maintenance of protein location
intersection_of: occurs_in GO:0009507 ! chloroplast
relationship: occurs_in GO:0009507 ! chloroplast
relationship: part_of GO:0072598 ! protein localization to chloroplast
created_by: midori
creation_date: 2011-02-14T02:17:48Z

[Term]
id: GO:0072598
name: protein localization to chloroplast
namespace: biological_process
def: "A process in which a protein is transported to, or maintained at, a location in a chloroplast." [GOC:ecd]
synonym: "protein localisation to chloroplast" EXACT [GOC:mah]
is_a: GO:0033365 ! protein localization to organelle
created_by: midori
creation_date: 2011-02-14T02:20:30Z

[Term]
id: GO:0072599
name: establishment of protein localization to endoplasmic reticulum
namespace: biological_process
def: "The directed movement of a protein to a specific location in the endoplasmic reticulum." [GOC:mah]
synonym: "establishment of protein localisation to endoplasmic reticulum" EXACT [GOC:mah]
synonym: "establishment of protein localisation to ER" EXACT [GOC:mah]
synonym: "establishment of protein localization in endoplasmic reticulum" EXACT [GOC:curators]
synonym: "establishment of protein localization to ER" EXACT [GOC:mah]
is_a: GO:0072594 ! establishment of protein localization to organelle
relationship: part_of GO:0070972 ! protein localization to endoplasmic reticulum
created_by: midori
creation_date: 2011-02-14T02:23:41Z

[Term]
id: GO:0072600
name: establishment of protein localization to Golgi
namespace: biological_process
def: "The directed movement of a protein to a specific location in the Golgi apparatus." [GOC:mah]
synonym: "establishment of protein localisation to Golgi" EXACT [GOC:mah]
synonym: "establishment of protein localisation to Golgi apparatus" EXACT [GOC:mah]
synonym: "establishment of protein localization in Golgi" EXACT [GOC:curators]
synonym: "establishment of protein localization to Golgi apparatus" EXACT [GOC:mah]
is_a: GO:0072594 ! establishment of protein localization to organelle
relationship: part_of GO:0034067 ! protein localization to Golgi apparatus
created_by: midori
creation_date: 2011-02-14T02:26:36Z

[Term]
id: GO:0072601
name: interleukin-3 secretion
namespace: biological_process
def: "The regulated release of interleukin-3 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
synonym: "IL-3 secretion" EXACT [GOC:BHF]
is_a: GO:0050663 ! cytokine secretion
relationship: part_of GO:0032632 ! interleukin-3 production

[Term]
id: GO:0072602
name: interleukin-4 secretion
namespace: biological_process
def: "The regulated release of interleukin-4 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
synonym: "IL-4 secretion" EXACT [GOC:BHF]
is_a: GO:0050663 ! cytokine secretion
relationship: part_of GO:0032633 ! interleukin-4 production

[Term]
id: GO:0072603
name: interleukin-5 secretion
namespace: biological_process
def: "The regulated release of interleukin-5 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
synonym: "IL-5 secretion" EXACT [GOC:BHF]
is_a: GO:0050663 ! cytokine secretion
relationship: part_of GO:0032634 ! interleukin-5 production

[Term]
id: GO:0072604
name: interleukin-6 secretion
namespace: biological_process
def: "The regulated release of interleukin-6 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
synonym: "IL-6 secretion" EXACT [GOC:BHF]
is_a: GO:0050663 ! cytokine secretion
relationship: part_of GO:0032635 ! interleukin-6 production

[Term]
id: GO:0072605
name: interleukin-7 secretion
namespace: biological_process
def: "The regulated release of interleukin-7 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
synonym: "IL-7 secretion" EXACT [GOC:BHF]
is_a: GO:0050663 ! cytokine secretion
relationship: part_of GO:0032636 ! interleukin-7 production

[Term]
id: GO:0072606
name: interleukin-8 secretion
namespace: biological_process
def: "The regulated release of interleukin-8 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
synonym: "IL-8 secretion" EXACT [GOC:BHF]
is_a: GO:0050663 ! cytokine secretion
relationship: part_of GO:0032637 ! interleukin-8 production

[Term]
id: GO:0072607
name: interleukin-9 secretion
namespace: biological_process
def: "The regulated release of interleukin-9 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
synonym: "IL-9 secretion" EXACT [GOC:BHF]
is_a: GO:0050663 ! cytokine secretion
relationship: part_of GO:0032638 ! interleukin-9 production

[Term]
id: GO:0072608
name: interleukin-10 secretion
namespace: biological_process
def: "The regulated release of interleukin-10 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
synonym: "IL-10 secretion" EXACT [GOC:BHF]
is_a: GO:0050663 ! cytokine secretion
relationship: part_of GO:0032613 ! interleukin-10 production

[Term]
id: GO:0072609
name: interleukin-11 secretion
namespace: biological_process
def: "The regulated release of interleukin-11 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
synonym: "IL-11 secretion" EXACT [GOC:BHF]
is_a: GO:0050663 ! cytokine secretion
relationship: part_of GO:0032614 ! interleukin-11 production

[Term]
id: GO:0072610
name: interleukin-12 secretion
namespace: biological_process
def: "The regulated release of interleukin-12 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
synonym: "CLMF secretion" NARROW [GOC:BHF]
synonym: "IL-12 secretion" EXACT [GOC:BHF]
synonym: "IL12 secretion" EXACT [GOC:BHF]
synonym: "interleukin-12 complex secretion" EXACT [GOC:BHF]
synonym: "NKSF secretion" NARROW [GOC:BHF]
is_a: GO:0050663 ! cytokine secretion
relationship: part_of GO:0032615 ! interleukin-12 production

[Term]
id: GO:0072611
name: interleukin-13 secretion
namespace: biological_process
def: "The regulated release of interleukin-13 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
synonym: "IL-13 secretion" EXACT [GOC:BHF]
is_a: GO:0050663 ! cytokine secretion
relationship: part_of GO:0032616 ! interleukin-13 production

[Term]
id: GO:0072612
name: interleukin-14 secretion
namespace: biological_process
def: "The regulated release of interleukin-14 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
synonym: "IL-14 secretion" EXACT [GOC:BHF]
is_a: GO:0050663 ! cytokine secretion
relationship: part_of GO:0032617 ! interleukin-14 production

[Term]
id: GO:0072613
name: interleukin-15 secretion
namespace: biological_process
def: "The regulated release of interleukin-15 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
synonym: "IL-15 secretion" EXACT [GOC:BHF]
is_a: GO:0050663 ! cytokine secretion
relationship: part_of GO:0032618 ! interleukin-15 production

[Term]
id: GO:0072614
name: interleukin-16 secretion
namespace: biological_process
def: "The regulated release of interleukin-16 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
synonym: "IL-16 secretion" EXACT [GOC:BHF]
synonym: "IL16 secretion" EXACT [GOC:BHF]
synonym: "LCF secretion" NARROW [GOC:BHF]
synonym: "pro-interleukin-16 secretion" EXACT [GOC:BHF]
is_a: GO:0050663 ! cytokine secretion
relationship: part_of GO:0032619 ! interleukin-16 production

[Term]
id: GO:0072615
name: interleukin-17 secretion
namespace: biological_process
def: "The regulated release of any member of the interleukin-17 family of cytokines from a cell." [GOC:add, GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
synonym: "CTLA-8 secretion" EXACT [GOC:BHF]
synonym: "Cytotoxic T-lymphocyte-associated antigen 8 secretion" EXACT [GOC:BHF]
synonym: "IL-17 secretion" EXACT [GOC:BHF]
synonym: "IL-17A secretion" EXACT [GOC:BHF]
synonym: "IL17A secretion" EXACT [GOC:BHF]
is_a: GO:0050663 ! cytokine secretion
relationship: part_of GO:0032620 ! interleukin-17 production

[Term]
id: GO:0072616
name: interleukin-18 secretion
namespace: biological_process
def: "The regulated release of interleukin-18 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
synonym: "IGIF secretion" EXACT [GOC:BHF]
synonym: "IL-18 secretion" EXACT [GOC:BHF]
synonym: "IL1F4 secretion" NARROW [GOC:BHF]
is_a: GO:0050663 ! cytokine secretion
relationship: part_of GO:0032621 ! interleukin-18 production

[Term]
id: GO:0072617
name: interleukin-19 secretion
namespace: biological_process
def: "The regulated release of interleukin-19 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
synonym: "IL-19 secretion" EXACT [GOC:BHF]
synonym: "ZMDA1 secretion" NARROW [GOC:BHF]
is_a: GO:0050663 ! cytokine secretion
relationship: part_of GO:0032622 ! interleukin-19 production

[Term]
id: GO:0072618
name: interleukin-20 secretion
namespace: biological_process
def: "The regulated release of interleukin-20 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
synonym: "IL-20 secretion" EXACT [GOC:BHF]
synonym: "ZCYTO10 secretion" EXACT [GOC:BHF]
is_a: GO:0050663 ! cytokine secretion
relationship: part_of GO:0032624 ! interleukin-20 production

[Term]
id: GO:0072619
name: interleukin-21 secretion
namespace: biological_process
def: "The regulated release of interleukin-21 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
synonym: "IL-21 secretion" EXACT [GOC:BHF]
synonym: "IL21 secretion" EXACT [GOC:BHF]
is_a: GO:0050663 ! cytokine secretion
relationship: part_of GO:0032625 ! interleukin-21 production

[Term]
id: GO:0072620
name: interleukin-22 secretion
namespace: biological_process
def: "The regulated release of interleukin-22 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
synonym: "IL-22 secretion" EXACT [GOC:BHF]
synonym: "IL22 secretion" EXACT [GOC:BHF]
synonym: "ILTIF secretion" EXACT [GOC:BHF]
synonym: "ZCYTO18 secretion" NARROW [GOC:BHF]
is_a: GO:0050663 ! cytokine secretion
relationship: part_of GO:0032626 ! interleukin-22 production

[Term]
id: GO:0072621
name: interleukin-23 secretion
namespace: biological_process
def: "The regulated release of interleukin-23 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
synonym: "IL-23 secretion" EXACT [GOC:BHF]
synonym: "IL23 secretion" EXACT [GOC:BHF]
synonym: "interleukin-23 complex secretion" EXACT [GOC:BHF]
is_a: GO:0050663 ! cytokine secretion
relationship: part_of GO:0032627 ! interleukin-23 production

[Term]
id: GO:0072622
name: interleukin-24 secretion
namespace: biological_process
def: "The regulated release of interleukin-24 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
synonym: "IL-24 secretion" EXACT [GOC:BHF]
synonym: "IL24 secretion" EXACT [GOC:BHF]
synonym: "MDA7 secretion" EXACT [GOC:BHF]
synonym: "ST16 secretion" NARROW [GOC:BHF]
is_a: GO:0050663 ! cytokine secretion
relationship: part_of GO:0032628 ! interleukin-24 production

[Term]
id: GO:0072623
name: interleukin-25 secretion
namespace: biological_process
def: "The regulated release of interleukin-25 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
synonym: "IL-25 secretion" EXACT [GOC:BHF]
synonym: "IL17E secretion" EXACT [GOC:BHF]
synonym: "IL25 secretion" EXACT [GOC:BHF]
is_a: GO:0050663 ! cytokine secretion
relationship: part_of GO:0032629 ! interleukin-25 production

[Term]
id: GO:0072624
name: interleukin-26 secretion
namespace: biological_process
def: "The regulated release of interleukin-26 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
synonym: "AK155 secretion" NARROW [GOC:BHF]
synonym: "IL-26 secretion" EXACT [GOC:BHF]
synonym: "IL26 secretion" EXACT [GOC:BHF]
is_a: GO:0050663 ! cytokine secretion
relationship: part_of GO:0032630 ! interleukin-26 production

[Term]
id: GO:0072625
name: interleukin-27 secretion
namespace: biological_process
def: "The regulated release of interleukin-27 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
synonym: "IL-27 secretion" EXACT [GOC:BHF]
synonym: "IL27 secretion" EXACT [GOC:BHF]
synonym: "interleukin-27 complex secretion" EXACT [GOC:BHF]
is_a: GO:0050663 ! cytokine secretion
relationship: part_of GO:0032631 ! interleukin-27 production

[Term]
id: GO:0072626
name: interleukin-35 secretion
namespace: biological_process
def: "The regulated release of interleukin-35 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
synonym: "IL-35 secretion" EXACT [GOC:BHF]
synonym: "IL35 secretion" EXACT [GOC:BHF]
synonym: "interleukin-35 complex secretion" EXACT [GOC:BHF]
is_a: GO:0050663 ! cytokine secretion
relationship: part_of GO:0070753 ! interleukin-35 production

[Term]
id: GO:0072627
name: interleukin-28A production
namespace: biological_process
def: "The appearance of interleukin-28A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
synonym: "IL-28A production" EXACT [GOC:BHF]
synonym: "IL28A production" EXACT [GOC:BHF]
synonym: "interferon lambda 2 production" EXACT [GOC:BHF]
is_a: GO:0034343 ! type III interferon production

[Term]
id: GO:0072628
name: interleukin-28A secretion
namespace: biological_process
def: "The regulated release of interleukin-28A from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
synonym: "IL-28A secretion" EXACT [GOC:BHF]
synonym: "IL28A secretion" EXACT [GOC:BHF]
synonym: "interferon lambda 2 secretion" EXACT [GOC:BHF]
is_a: GO:0072644 ! type III interferon secretion
relationship: part_of GO:0072627 ! interleukin-28A production

[Term]
id: GO:0072629
name: interleukin-28B production
namespace: biological_process
def: "The appearance of interleukin-28B due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
synonym: "IL-28B production" EXACT [GOC:BHF]
synonym: "IL28B production" EXACT [GOC:BHF]
synonym: "interferon lambda 3 production" EXACT [GOC:BHF]
is_a: GO:0034343 ! type III interferon production

[Term]
id: GO:0072630
name: interleukin-28B secretion
namespace: biological_process
def: "The regulated release of interleukin-28B from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
synonym: "IL-28B secretion" EXACT [GOC:BHF]
synonym: "IL28B secretion" EXACT [GOC:BHF]
synonym: "interferon lambda 3 secretion" EXACT [GOC:BHF]
is_a: GO:0072644 ! type III interferon secretion
relationship: part_of GO:0072629 ! interleukin-28B production

[Term]
id: GO:0072631
name: interleukin-29 production
namespace: biological_process
def: "The appearance of interleukin-29 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
synonym: "IL-29 production" EXACT [GOC:BHF]
synonym: "IL29 production" EXACT [GOC:BHF]
synonym: "interferon lambda 1 production" EXACT [GOC:BHF]
is_a: GO:0034343 ! type III interferon production

[Term]
id: GO:0072632
name: interleukin-29 secretion
namespace: biological_process
def: "The regulated release of interleukin-29 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
synonym: "IL-29 secretion" EXACT [GOC:BHF]
synonym: "IL29 secretion" EXACT [GOC:BHF]
synonym: "interferon lambda 1 secretion" EXACT [GOC:BHF]
is_a: GO:0072644 ! type III interferon secretion
relationship: part_of GO:0072631 ! interleukin-29 production

[Term]
id: GO:0072633
name: interleukin-30 production
namespace: biological_process
def: "The appearance of interleukin-30 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
synonym: "IL-30 production" EXACT [GOC:BHF]
synonym: "interleukin-30 complex production" EXACT [GOC:BHF]
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0072634
name: interleukin-30 secretion
namespace: biological_process
def: "The regulated release of interleukin-30 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
synonym: "IL-30 secretion" EXACT [GOC:BHF]
synonym: "interleukin-30 complex secretion" EXACT [GOC:BHF]
is_a: GO:0050663 ! cytokine secretion
relationship: part_of GO:0072633 ! interleukin-30 production

[Term]
id: GO:0072635
name: interleukin-31 production
namespace: biological_process
def: "The appearance of interleukin-31 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
synonym: "IL-31 production" EXACT [GOC:BHF]
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0072636
name: interleukin-31 secretion
namespace: biological_process
def: "The regulated release of interleukin-31 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
synonym: "IL-31 secretion" EXACT [GOC:BHF]
is_a: GO:0050663 ! cytokine secretion
relationship: part_of GO:0072635 ! interleukin-31 production

[Term]
id: GO:0072637
name: interleukin-32 production
namespace: biological_process
def: "The appearance of interleukin-32 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
synonym: "IL-32 production" EXACT [GOC:BHF]
synonym: "IL32 production" EXACT [GOC:BHF]
synonym: "NK4 production" NARROW [GOC:BHF]
synonym: "TAIF production" NARROW [GOC:BHF]
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0072638
name: interleukin-32 secretion
namespace: biological_process
def: "The regulated release of interleukin-32 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
synonym: "IL-32 secretion" EXACT [GOC:BHF]
synonym: "IL32 secretion" EXACT [GOC:BHF]
synonym: "NK4 secretion" NARROW [GOC:BHF]
synonym: "TAIF secretion" NARROW [GOC:BHF]
is_a: GO:0050663 ! cytokine secretion
relationship: part_of GO:0072637 ! interleukin-32 production

[Term]
id: GO:0072639
name: interleukin-33 production
namespace: biological_process
def: "The appearance of interleukin-33 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
synonym: "C9orf26 production" NARROW [GOC:BHF]
synonym: "IL-33 production" EXACT [GOC:BHF]
synonym: "IL1F11 production" NARROW [GOC:BHF]
synonym: "IL33 production" EXACT [GOC:BHF]
synonym: "NF-HEV production" EXACT [GOC:BHF]
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0072640
name: interleukin-33 secretion
namespace: biological_process
def: "The regulated release of interleukin-33 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
synonym: "C9orf26 secretion" NARROW [GOC:BHF]
synonym: "IL-33 secretion" EXACT [GOC:BHF]
synonym: "IL1F11 secretion" NARROW [GOC:BHF]
synonym: "IL33 secretion" EXACT [GOC:BHF]
synonym: "NF-HEV secretion" EXACT [GOC:BHF]
is_a: GO:0050663 ! cytokine secretion
relationship: part_of GO:0072639 ! interleukin-33 production

[Term]
id: GO:0072641
name: type I interferon secretion
namespace: biological_process
def: "The regulated release of type I interferon from a cell." [GOC:BHF, GOC:mah, PMID:15546383]
synonym: "type I IFN secretion" EXACT [GOC:mah]
is_a: GO:0050663 ! cytokine secretion
relationship: part_of GO:0032606 ! type I interferon production

[Term]
id: GO:0072642
name: interferon-alpha secretion
namespace: biological_process
def: "The regulated release of interferon-alpha from a cell." [GOC:BHF, GOC:mah, PMID:15546383]
synonym: "IFN-alpha secretion" EXACT [GOC:mah]
synonym: "IFNA secretion" EXACT [GOC:BHF]
is_a: GO:0072641 ! type I interferon secretion
relationship: part_of GO:0032607 ! interferon-alpha production

[Term]
id: GO:0072643
name: interferon-gamma secretion
namespace: biological_process
def: "The regulated release of interferon-gamma from a cell." [GOC:BHF, GOC:mah, PMID:15546383]
synonym: "IFN-gamma secretion" EXACT [GOC:mah]
synonym: "IFNG secretion" EXACT [GOC:BHF]
synonym: "type II IFN secretion" BROAD [GOC:mah]
synonym: "type II interferon secretion" BROAD [GOC:BHF]
is_a: GO:0050663 ! cytokine secretion
relationship: part_of GO:0032609 ! interferon-gamma production

[Term]
id: GO:0072644
name: type III interferon secretion
namespace: biological_process
def: "The regulated release of type III interferon from a cell. Interferon lambda is the only member of the type III interferon found so far." [GOC:BHF, GOC:mah, PMID:15546383]
synonym: "type III IFN secretion" EXACT [GOC:mah]
is_a: GO:0050663 ! cytokine secretion
relationship: part_of GO:0034343 ! type III interferon production

[Term]
id: GO:0072645
name: interferon-delta production
namespace: biological_process
def: "The appearance of interferon-delta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383]
synonym: "IFN-delta production" EXACT [GOC:mah]
synonym: "IFND production" EXACT [GOC:BHF]
is_a: GO:0032606 ! type I interferon production

[Term]
id: GO:0072646
name: interferon-delta secretion
namespace: biological_process
def: "The regulated release of interferon-delta from a cell." [GOC:BHF, GOC:mah, PMID:15546383]
synonym: "IFN-delta secretion" EXACT [GOC:mah]
synonym: "IFND secretion" EXACT [GOC:BHF]
is_a: GO:0072641 ! type I interferon secretion
relationship: part_of GO:0072645 ! interferon-delta production

[Term]
id: GO:0072647
name: interferon-epsilon production
namespace: biological_process
def: "The appearance of interferon-epsilon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383]
synonym: "IFN-epsilon production" EXACT [GOC:mah]
synonym: "IFNE production" EXACT [GOC:BHF]
is_a: GO:0032606 ! type I interferon production

[Term]
id: GO:0072648
name: interferon-epsilon secretion
namespace: biological_process
def: "The regulated release of interferon-epsilon from a cell." [GOC:BHF, GOC:mah, PMID:15546383]
synonym: "IFN-epsilon secretion" EXACT [GOC:mah]
synonym: "IFNE secretion" EXACT [GOC:BHF]
is_a: GO:0072641 ! type I interferon secretion
relationship: part_of GO:0072647 ! interferon-epsilon production

[Term]
id: GO:0072649
name: interferon-kappa production
namespace: biological_process
def: "The appearance of interferon-kappa due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383]
synonym: "IFN-kappa production" EXACT [GOC:mah]
synonym: "IFNK production" EXACT [GOC:BHF]
is_a: GO:0032606 ! type I interferon production

[Term]
id: GO:0072650
name: interferon-kappa secretion
namespace: biological_process
def: "The regulated release of interferon-kappa from a cell." [GOC:BHF, GOC:mah, PMID:15546383]
synonym: "IFN-kappa secretion" EXACT [GOC:mah]
synonym: "IFNK secretion" EXACT [GOC:BHF]
is_a: GO:0072641 ! type I interferon secretion
relationship: part_of GO:0072649 ! interferon-kappa production

[Term]
id: GO:0072651
name: interferon-tau production
namespace: biological_process
def: "The appearance of interferon-tau due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383]
synonym: "IFN-tau production" EXACT [GOC:mah]
synonym: "IFNT production" EXACT [GOC:BHF]
is_a: GO:0032606 ! type I interferon production

[Term]
id: GO:0072652
name: interferon-tau secretion
namespace: biological_process
def: "The regulated release of interferon-tau from a cell." [GOC:BHF, GOC:mah, PMID:15546383]
synonym: "IFN-tau secretion" EXACT [GOC:mah]
synonym: "IFNT secretion" EXACT [GOC:BHF]
is_a: GO:0072641 ! type I interferon secretion
relationship: part_of GO:0072651 ! interferon-tau production

[Term]
id: GO:0072653
name: interferon-omega production
namespace: biological_process
def: "The appearance of interferon-omega due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383]
synonym: "IFN-omega production" EXACT [GOC:mah]
synonym: "IFNW production" EXACT [GOC:BHF]
is_a: GO:0032606 ! type I interferon production

[Term]
id: GO:0072654
name: interferon-omega secretion
namespace: biological_process
def: "The regulated release of interferon-omega from a cell." [GOC:BHF, GOC:mah, PMID:15546383]
synonym: "IFN-omega secretion" EXACT [GOC:mah]
synonym: "IFNW secretion" EXACT [GOC:BHF]
is_a: GO:0072641 ! type I interferon secretion
relationship: part_of GO:0072653 ! interferon-omega production

[Term]
id: GO:0072655
name: establishment of protein localization to mitochondrion
namespace: biological_process
def: "The directed movement of a protein to the mitochondrion or a part of the mitochondrion." [GOC:mah]
synonym: "establishment of protein localisation to mitochondrion" EXACT [GOC:mah]
synonym: "establishment of protein localization in mitochondrion" EXACT [GOC:curators]
is_a: GO:0072594 ! establishment of protein localization to organelle
relationship: part_of GO:0070585 ! protein localization to mitochondrion
created_by: midori
creation_date: 2011-02-14T02:28:54Z

[Term]
id: GO:0072656
name: maintenance of protein location in mitochondrion
namespace: biological_process
def: "Any process in which a protein is maintained in a specific location in a mitochondrion, and is prevented from moving elsewhere." [GOC:mah]
is_a: GO:0051220 ! cytoplasmic sequestering of protein
is_a: GO:0072595 ! maintenance of protein localization in organelle
intersection_of: GO:0045185 ! maintenance of protein location
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion
relationship: part_of GO:0070585 ! protein localization to mitochondrion
created_by: midori
creation_date: 2011-02-14T02:30:43Z

[Term]
id: GO:0072657
name: protein localization to membrane
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a specific location in a membrane." [GOC:mah]
synonym: "protein localisation in membrane" EXACT [GOC:mah]
synonym: "protein localization in membrane" EXACT [GOC:curators]
is_a: GO:0034613 ! cellular protein localization
is_a: GO:0044802 ! single-organism membrane organization
is_a: GO:1902580 ! single-organism cellular localization
created_by: midori
creation_date: 2011-02-14T02:35:18Z

[Term]
id: GO:0072658
name: maintenance of protein location in membrane
namespace: biological_process
def: "Any process in which a protein is maintained in a specific location in a membrane, and is prevented from moving elsewhere." [GOC:mah]
is_a: GO:0032507 ! maintenance of protein location in cell
relationship: part_of GO:0072657 ! protein localization to membrane
created_by: midori
creation_date: 2011-02-14T02:39:41Z

[Term]
id: GO:0072659
name: protein localization to plasma membrane
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah]
synonym: "protein localisation in plasma membrane" EXACT [GOC:mah]
synonym: "protein localization in plasma membrane" EXACT [GOC:curators]
is_a: GO:0007009 ! plasma membrane organization
is_a: GO:0072657 ! protein localization to membrane
is_a: GO:1990778 ! protein localization to cell periphery
created_by: midori
creation_date: 2011-02-14T02:43:05Z

[Term]
id: GO:0072660
name: maintenance of protein location in plasma membrane
namespace: biological_process
def: "Any process in which a protein is maintained in a specific location in the plasma membrane, and is prevented from moving elsewhere." [GOC:mah]
is_a: GO:0072658 ! maintenance of protein location in membrane
relationship: part_of GO:0072659 ! protein localization to plasma membrane
created_by: midori
creation_date: 2011-02-14T02:46:08Z

[Term]
id: GO:0072661
name: protein targeting to plasma membrane
namespace: biological_process
def: "The process of directing proteins towards the plasma membrane; usually uses signals contained within the protein." [GOC:mah]
synonym: "protein-plasma membrane targeting" EXACT [GOC:mah]
is_a: GO:0006612 ! protein targeting to membrane
is_a: GO:0072659 ! protein localization to plasma membrane
is_a: GO:0090002 ! establishment of protein localization to plasma membrane
created_by: midori
creation_date: 2011-02-14T02:48:15Z

[Term]
id: GO:0072662
name: protein localization to peroxisome
namespace: biological_process
def: "A process in which a protein is transported to, or maintained at, a location in a peroxisome." [GOC:ecd]
synonym: "protein localisation to peroxisome" EXACT [GOC:mah]
is_a: GO:0007031 ! peroxisome organization
is_a: GO:0033365 ! protein localization to organelle
is_a: GO:1902580 ! single-organism cellular localization
is_a: GO:1902589 ! single-organism organelle organization
created_by: midori
creation_date: 2011-02-14T02:50:04Z

[Term]
id: GO:0072663
name: establishment of protein localization to peroxisome
namespace: biological_process
def: "The directed movement of a protein to a specific location in a peroxisome." [GOC:mah]
synonym: "establishment of protein localisation to peroxisome" EXACT [GOC:mah]
is_a: GO:0072594 ! establishment of protein localization to organelle
relationship: part_of GO:0072662 ! protein localization to peroxisome
created_by: midori
creation_date: 2011-02-14T02:50:36Z

[Term]
id: GO:0072664
name: maintenance of protein location in peroxisome
namespace: biological_process
def: "Any process in which a protein is maintained in a specific location in a peroxisome, and is prevented from moving elsewhere." [GOC:mah]
is_a: GO:0051220 ! cytoplasmic sequestering of protein
is_a: GO:0072595 ! maintenance of protein localization in organelle
intersection_of: GO:0045185 ! maintenance of protein location
intersection_of: occurs_in GO:0005777 ! peroxisome
relationship: occurs_in GO:0005777 ! peroxisome
relationship: part_of GO:0072662 ! protein localization to peroxisome
created_by: midori
creation_date: 2011-02-14T02:51:51Z

[Term]
id: GO:0072665
name: protein localization to vacuole
namespace: biological_process
def: "A process in which a protein is transported to, or maintained at, a location in a vacuole." [GOC:ecd]
synonym: "protein localisation to vacuole" EXACT [GOC:mah]
is_a: GO:0033365 ! protein localization to organelle
created_by: midori
creation_date: 2011-02-14T02:55:35Z

[Term]
id: GO:0072666
name: establishment of protein localization to vacuole
namespace: biological_process
def: "The directed movement of a protein to a specific location in a vacuole." [GOC:mah]
synonym: "establishment of protein localisation to vacuole" EXACT [GOC:mah]
is_a: GO:0072594 ! establishment of protein localization to organelle
relationship: part_of GO:0072665 ! protein localization to vacuole
created_by: midori
creation_date: 2011-02-14T02:56:29Z

[Term]
id: GO:0072667
name: maintenance of protein location in vacuole
namespace: biological_process
def: "Any process in which a protein is maintained in a specific location in a vacuole, and is prevented from moving elsewhere." [GOC:mah]
is_a: GO:0051220 ! cytoplasmic sequestering of protein
is_a: GO:0072595 ! maintenance of protein localization in organelle
intersection_of: GO:0045185 ! maintenance of protein location
intersection_of: occurs_in GO:0005773 ! vacuole
relationship: occurs_in GO:0005773 ! vacuole
relationship: part_of GO:0072665 ! protein localization to vacuole
created_by: midori
creation_date: 2011-02-14T02:56:57Z

[Term]
id: GO:0072668
name: obsolete tubulin complex biogenesis
namespace: biological_process
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a tubulin complex. Includes the synthesis and folding of the constituent protein molecules, and those protein modifications that are involved in synthesis or assembly of the complex. A tubulin complex is a heterodimer of tubulins alpha and beta, from which microtubules are assembled." [GOC:mah]
comment: This term was obsoleted becuase biogenesis should only be used for complexes where synthesis of some non-protein component is necessary for assembly.
synonym: "tubulin complex biogenesis" EXACT []
is_obsolete: true
replaced_by: GO:0007021
created_by: midori
creation_date: 2011-02-14T03:25:18Z

[Term]
id: GO:0072669
name: tRNA-splicing ligase complex
namespace: cellular_component
def: "A protein complex that catalyzes the ligation of cleaved pre-tRNAs by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester." [GOC:sp, PMID:21311021]
synonym: "tRNA splicing ligase complex" EXACT [GOC:mah]
xref: MetaCyc:ENTMULTI-CPLX
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
created_by: midori
creation_date: 2011-02-18T10:55:26Z

[Term]
id: GO:0072670
name: mitochondrial tRNA threonylcarbamoyladenosine modification
namespace: biological_process
def: "The attachment of a carbonyl group and a threonine to the amino group of the adenine residue immediately 3' of the anticodon, in mitochondrial tRNAs that decode ANN codons (where N is any base)." [GOC:mcc, PMID:21183954]
synonym: "mitochondrial tRNA t6A modification" EXACT [GOC:mcc]
is_a: GO:0070900 ! mitochondrial tRNA modification
created_by: midori
creation_date: 2011-02-18T11:34:35Z

[Term]
id: GO:0072671
name: mitochondria-associated ubiquitin-dependent protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of proteins transported from mitochondria and targeted to cytoplasmic proteasomes for degradation as a response to oxidative stress conditions." [GOC:mcc, PMID:21070972, PMID:21109188]
synonym: "MAD" EXACT [GOC:mcc]
synonym: "mitochondria-associated protein catabolic process" EXACT []
synonym: "mitochondria-associated protein degradation" EXACT [GOC:mcc]
synonym: "mitochondrion-associated protein catabolic process" EXACT [GOC:mah]
is_a: GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process
created_by: midori
creation_date: 2011-02-18T11:53:28Z

[Term]
id: GO:0072672
name: neutrophil extravasation
namespace: biological_process
def: "The migration of a neutrophil from the blood vessels into the surrounding tissue." [CL:0000775, GOC:BHF]
is_a: GO:0045123 ! cellular extravasation
is_a: GO:1990266 ! neutrophil migration
created_by: midori
creation_date: 2011-02-21T03:03:52Z

[Term]
id: GO:0072673
name: lamellipodium morphogenesis
namespace: biological_process
def: "A process that is carried out at the cellular level and in which the structure of a lamellipodium is organized." [GOC:BHF, GOC:mah]
synonym: "lamellipodium organization" RELATED [GOC:mah]
is_a: GO:0048858 ! cell projection morphogenesis
is_a: GO:0097581 ! lamellipodium organization
created_by: midori
creation_date: 2011-02-21T03:11:55Z

[Term]
id: GO:0072674
name: multinuclear osteoclast differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized monocyte acquires the specialized features of a multinuclear osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue." [CL:0000779, GOC:mah, PMID:12713016]
synonym: "multinuclear osteoclast formation" RELATED [GOC:BHF, GOC:mah]
synonym: "multinuclear osteoclast morphogenesis" RELATED [GOC:BHF, GOC:mah]
is_a: GO:0030316 ! osteoclast differentiation
created_by: midori
creation_date: 2011-02-22T02:10:38Z

[Term]
id: GO:0072675
name: osteoclast fusion
namespace: biological_process
def: "The plasma membrane fusion process that results in fusion of mononuclear osteoclasts to form a multinuclear osteoclast." [CL:0000092, CL:0000779, GOC:BHF, GOC:mah, PMID:12713016]
is_a: GO:0000768 ! syncytium formation by plasma membrane fusion
relationship: part_of GO:0072674 ! multinuclear osteoclast differentiation
created_by: midori
creation_date: 2011-02-22T02:14:34Z

[Term]
id: GO:0072676
name: lymphocyte migration
namespace: biological_process
def: "The movement of a lymphocyte within or between different tissues and organs of the body." [CL:0000542, GOC:BHF, GOC:mah]
is_a: GO:0050900 ! leukocyte migration
created_by: midori
creation_date: 2011-02-22T03:38:12Z

[Term]
id: GO:0072677
name: eosinophil migration
namespace: biological_process
def: "The movement of an eosinophil within or between different tissues and organs of the body." [CL:0000771, GOC:BHF, GOC:mah]
is_a: GO:0097530 ! granulocyte migration
created_by: midori
creation_date: 2011-02-22T03:39:31Z

[Term]
id: GO:0072678
name: T cell migration
namespace: biological_process
def: "The movement of a T cell within or between different tissues and organs of the body." [CL:0000084, GOC:BHF, GOC:mah]
synonym: "T lymphocyte migration" EXACT [CL:0000084]
synonym: "T-cell migration" EXACT [CL:0000084]
synonym: "T-lymphocyte migration" EXACT [CL:0000084]
is_a: GO:0072676 ! lymphocyte migration
created_by: midori
creation_date: 2011-02-22T03:40:40Z

[Term]
id: GO:0072679
name: thymocyte migration
namespace: biological_process
def: "The movement of a thymocyte through distinct intrathymic niches (e.g. medulla, cortex), where it receives a unique set of developmental cues required for T-cell development." [CL:0000893, GOC:BHF, GOC:mah]
synonym: "immature T cell migration" RELATED [CL:0000893]
synonym: "immature T lymphocyte migration" RELATED [CL:0000893]
synonym: "immature T-cell migration" RELATED [CL:0000893]
synonym: "immature T-lymphocyte migration" RELATED [CL:0000893]
synonym: "thymic lymphocyte migration" EXACT [CL:0000893]
is_a: GO:0072678 ! T cell migration
created_by: midori
creation_date: 2011-02-22T03:47:51Z

[Term]
id: GO:0072680
name: extracellular matrix-dependent thymocyte migration
namespace: biological_process
def: "The movement of a thymocyte through distinct intrathymic niches (e.g. medulla, cortex), where it receives a unique set of developmental cues required for T-cell development, dependent on extracellular matrix components including fibronectin, collagen and laminin." [CL:0000893, GOC:BHF, GOC:mah, PMID:20856819]
synonym: "extracellular matrix-dependent immature T cell migration" RELATED [CL:0000893, GOC:mah]
synonym: "extracellular matrix-dependent immature T lymphocyte migration" RELATED [CL:0000893, GOC:mah]
synonym: "extracellular matrix-dependent immature T-cell migration" RELATED [CL:0000893, GOC:mah]
synonym: "extracellular matrix-dependent immature T-lymphocyte migration" RELATED [CL:0000893, GOC:mah]
synonym: "extracellular matrix-dependent thymic lymphocyte migration" EXACT [CL:0000893, GOC:mah]
is_a: GO:0006929 ! substrate-dependent cell migration
is_a: GO:0072679 ! thymocyte migration
created_by: midori
creation_date: 2011-02-22T03:49:57Z

[Term]
id: GO:0072681
name: fibronectin-dependent thymocyte migration
namespace: biological_process
def: "The movement of a thymocyte through distinct intrathymic niches (e.g. medulla, cortex), where it receives a unique set of developmental cues required for T-cell development, dependent on fibronectin in the extracellular matrix." [CL:0000893, GOC:BHF, GOC:mah, PMID:20856819]
synonym: "fibronectin-dependent immature T cell migration" RELATED [CL:0000893, GOC:mah]
synonym: "fibronectin-dependent immature T lymphocyte migration" RELATED [CL:0000893, GOC:mah]
synonym: "fibronectin-dependent immature T-cell migration" RELATED [CL:0000893, GOC:mah]
synonym: "fibronectin-dependent immature T-lymphocyte migration" RELATED [CL:0000893, GOC:mah]
synonym: "fibronectin-dependent thymic lymphocyte migration" EXACT [CL:0000893, GOC:mah]
is_a: GO:0072680 ! extracellular matrix-dependent thymocyte migration
created_by: midori
creation_date: 2011-02-22T03:53:06Z

[Term]
id: GO:0072682
name: eosinophil extravasation
namespace: biological_process
def: "The migration of an eosinophil from the blood vessels into the surrounding tissue." [CL:0000771, GOC:BHF, GOC:mah]
is_a: GO:0045123 ! cellular extravasation
is_a: GO:0072677 ! eosinophil migration
created_by: midori
creation_date: 2011-02-22T04:02:22Z

[Term]
id: GO:0072683
name: T cell extravasation
namespace: biological_process
def: "The migration of a T cell from the blood vessels into the surrounding tissue." [CL:0000084, GOC:BHF, GOC:mah]
synonym: "T lymphocyte extravasation" EXACT [CL:0000084]
synonym: "T-cell extravasation" EXACT [CL:0000084]
synonym: "T-lymphocyte extravasation" EXACT [CL:0000084]
is_a: GO:0045123 ! cellular extravasation
is_a: GO:0072678 ! T cell migration
created_by: midori
creation_date: 2011-02-22T04:05:45Z

[Term]
id: GO:0072684
name: mitochondrial tRNA 3'-trailer cleavage, endonucleolytic
namespace: biological_process
def: "Endonucleolytic cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA in the mitochondrion." [GOC:mah]
synonym: "mitochondrial endonucleolytic tRNA 3'-end cleavage" EXACT [GOC:mah]
synonym: "mitochondrial endonucleolytic tRNA 3'-trailer cleavage" RELATED [GOC:mah]
synonym: "mitochondrial tRNA 3'-end cleavage, endonucleolytic" EXACT [GOC:mah]
is_a: GO:0034414 ! tRNA 3'-trailer cleavage, endonucleolytic
is_a: GO:1990180 ! mitochondrial tRNA 3'-end processing
intersection_of: GO:0034414 ! tRNA 3'-trailer cleavage, endonucleolytic
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion
created_by: midori
creation_date: 2011-02-23T01:32:52Z

[Term]
id: GO:0072685
name: Mre11 complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an Mre11 complex, a trimeric protein complex that possesses endonuclease activity and is involved in meiotic recombination, DNA repair and checkpoint signaling." [GOC:mah, PMID:19211838]
synonym: "MRN complex assembly" EXACT [GOC:mah]
synonym: "MRX complex assembly" EXACT [GOC:mah]
synonym: "Rad50 complex assembly" EXACT [GOC:mah]
synonym: "RAD50-MRE11-NBN complex assembly" EXACT [CORUM:2767, GOC:mah]
synonym: "Rad50-Rad32-Nbs1 complex assembly" EXACT [GOC:mah]
synonym: "RMX complex assembly" EXACT [GOC:mah]
is_a: GO:0043623 ! cellular protein complex assembly
created_by: midori
creation_date: 2011-05-12T02:52:06Z

[Term]
id: GO:0072686
name: mitotic spindle
namespace: cellular_component
def: "A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]
is_a: GO:0005819 ! spindle
created_by: midori
creation_date: 2011-07-08T05:08:16Z

[Term]
id: GO:0072687
name: meiotic spindle
namespace: cellular_component
def: "A spindle that forms as part of meiosis. Several proteins, such as budding yeast Spo21p, fission yeast Spo2 and Spo13, and C. elegans mei-1, localize specifically to the meiotic spindle and are absent from the mitotic spindle." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]
is_a: GO:0005819 ! spindle
created_by: midori
creation_date: 2011-07-08T05:17:08Z

[Term]
id: GO:0072688
name: SHREC complex localization
namespace: biological_process
def: "Any process in which a SHREC complex is transported to, or maintained in, a specific location." [GOC:mah]
synonym: "establishment and maintenance of SHREC complex localization" EXACT [GOC:mah]
synonym: "SHREC complex localisation" EXACT [GOC:mah]
is_a: GO:0034629 ! cellular protein complex localization
created_by: midori
creation_date: 2011-07-20T12:51:49Z

[Term]
id: GO:0072689
name: MCM complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an MCM complex, a hexameric protein complex required for the initiation and regulation of DNA replication." [GOC:mah, PMID:21813639]
is_a: GO:0043623 ! cellular protein complex assembly
created_by: midori
creation_date: 2011-08-12T10:57:29Z

[Term]
id: GO:0072690
name: single-celled organism vegetative growth phase
namespace: biological_process
def: "A phase of population growth during which single celled organisms reproduce by budding, fission, or other asexual methods." [GOC:mah, GOV:vw]
subset: gocheck_do_not_annotate
synonym: "vegetative growth of a single-celled organism" EXACT []
is_a: GO:0044848 ! biological phase
created_by: midori
creation_date: 2011-08-19T12:05:19Z

[Term]
id: GO:0072691
name: initiation of premeiotic DNA replication
namespace: biological_process
def: "A process of DNA-dependent DNA replication initiation that occurs as part of premeiotic DNA replication." [GOC:mah, PMID:10888871]
synonym: "initiation of meiotic DNA synthesis" RELATED [GOC:mah]
synonym: "initiation of premeiotic DNA synthesis" RELATED [GOC:mah]
synonym: "meiotic DNA replication initiation" RELATED [GOC:mah]
synonym: "premeiotic DNA replication initiation" EXACT [GOC:mah]
is_a: GO:1902974 ! meiotic DNA replication initiation
intersection_of: GO:0006270 ! DNA replication initiation
intersection_of: part_of GO:0006279 ! premeiotic DNA replication
relationship: part_of GO:0006279 ! premeiotic DNA replication
created_by: midori
creation_date: 2011-08-19T03:16:20Z

[Term]
id: GO:0072692
name: chromatin silencing at centromere central core
namespace: biological_process
def: "Repression of transcription of DNA at the central core of a regional centromere by altering the structure of chromatin." [GOC:mah]
synonym: "centromere central core chromatin silencing" EXACT [GOC:mah]
synonym: "chromatin silencing at centromeric central core" EXACT [GOC:vw]
synonym: "chromatin silencing at chromosome kinetochore domain" EXACT [GOC:vw]
synonym: "heterochromatic silencing at centromere central core" EXACT [GOC:mah]
is_a: GO:0030702 ! chromatin silencing at centromere
intersection_of: GO:0006342 ! chromatin silencing
intersection_of: occurs_in GO:0034506 ! chromosome, centromeric core domain
relationship: occurs_in GO:0034506 ! chromosome, centromeric core domain
created_by: midori
creation_date: 2011-09-12T03:16:41Z

[Term]
id: GO:0072693
name: protein targeting to prospore membrane
namespace: biological_process
def: "The process of directing proteins towards the prospore membrane; usually uses signals contained within the protein." [GOC:mah]
synonym: "protein targeting to ascospore-type prospore membrane" EXACT [GOC:mah]
synonym: "protein targeting to forespore membrane" RELATED [GOC:mah]
synonym: "protein targeting to FSM" EXACT [GOC:mah]
synonym: "protein-prospore membrane targeting" EXACT [GOC:mah]
is_a: GO:0006612 ! protein targeting to membrane
is_a: GO:1902657 ! protein localization to prospore membrane
is_a: GO:1902658 ! establishment of protein localization to prospore membrane
created_by: midori
creation_date: 2011-11-16T11:28:26Z

[Term]
id: GO:0072694
name: obsolete cell cycle arrest in response to caffeine
namespace: biological_process
def: "OBSOLETE. The cell cycle regulatory process in which the cell cycle is halted during one of the normal phases (G1, S, G2, M) as a result of a caffeine stimulus." [GOC:mah]
comment: This term was made obsolete because it does not represent a real process.
is_obsolete: true
created_by: midori
creation_date: 2011-12-05T01:29:00Z

[Term]
id: GO:0072695
name: regulation of DNA recombination at telomere
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA recombination within the telomere." [GOC:mah]
synonym: "regulation of telomeric recombination" EXACT [GOC:mah]
is_a: GO:0000018 ! regulation of DNA recombination
created_by: midori
creation_date: 2012-04-03T10:31:50Z

[Term]
id: GO:0072696
name: positive regulation of DNA recombination at telomere
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of genetic recombination within the telomere." [GOC:mah]
synonym: "activation of telomeric recombination at telomere" NARROW [GOC:mah]
synonym: "positive regulation of telomeric recombination" EXACT [GOC:mah]
synonym: "up regulation of telomeric recombination at telomere" EXACT [GOC:mah]
synonym: "up-regulation of telomeric recombination at telomere" EXACT [GOC:mah]
synonym: "upregulation of telomeric recombination at telomere" EXACT [GOC:mah]
is_a: GO:0045911 ! positive regulation of DNA recombination
is_a: GO:0072695 ! regulation of DNA recombination at telomere
created_by: midori
creation_date: 2012-04-03T11:28:19Z

[Term]
id: GO:0072697
name: protein localization to cell cortex
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, the cell cortex." [GOC:mah]
synonym: "protein localisation to cell cortex" EXACT [GOC:mah]
is_a: GO:1990778 ! protein localization to cell periphery
created_by: midori
creation_date: 2012-04-11T01:16:33Z

[Term]
id: GO:0072698
name: protein localization to microtubule cytoskeleton
namespace: biological_process
def: "A cellular protein localization process in which a protein is transported to, or maintained at, a location within the microtubule cytoskeleton." [GOC:mah]
synonym: "protein localisation to microtubule cytoskeleton" EXACT [GOC:mah]
is_a: GO:0044380 ! protein localization to cytoskeleton
created_by: midori
creation_date: 2012-04-11T01:19:35Z

[Term]
id: GO:0072699
name: protein localization to cortical microtubule cytoskeleton
namespace: biological_process
def: "A process in which a protein is transported to, or maintained at, a location within the cortical microtubule cytoskeleton." [GOC:mah]
synonym: "protein localisation to cortical microtubule cytoskeleton" EXACT [GOC:mah]
is_a: GO:0072697 ! protein localization to cell cortex
is_a: GO:0072698 ! protein localization to microtubule cytoskeleton
created_by: midori
creation_date: 2012-04-11T01:23:36Z

[Term]
id: GO:0072700
name: response to bismuth
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bismuth (Bi) stimulus." [CHEBI:33301, GOC:mah]
synonym: "response to bismuth ion" EXACT []
is_a: GO:0010035 ! response to inorganic substance
created_by: midori
creation_date: 2012-04-11T02:56:35Z

[Term]
id: GO:0072701
name: cellular response to bismuth
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bismuth (Bi) stimulus." [CHEBI:33301, GOC:mah]
synonym: "cellular response to bismuth ion" EXACT []
is_a: GO:0071241 ! cellular response to inorganic substance
is_a: GO:0072700 ! response to bismuth
created_by: midori
creation_date: 2012-04-11T02:56:42Z

[Term]
id: GO:0072702
name: response to methyl methanesulfonate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methyl methanesulfonate (MMS) stimulus." [CHEBI:25255, GOC:mah]
synonym: "response to MMS" EXACT [CHEBI:25255, GOC:mah]
is_a: GO:0010033 ! response to organic substance
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: midori
creation_date: 2012-04-11T03:04:12Z

[Term]
id: GO:0072703
name: cellular response to methyl methanesulfonate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methyl methanesulfonate (MMS) stimulus." [CHEBI:25255, GOC:mah]
synonym: "cellular response to MMS" EXACT [CHEBI:25255, GOC:mah]
is_a: GO:0071310 ! cellular response to organic substance
is_a: GO:0072702 ! response to methyl methanesulfonate
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: midori
creation_date: 2012-04-11T03:04:18Z

[Term]
id: GO:0072704
name: response to mercaptoethanol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercaptoethanol stimulus." [CHEBI:41218, GOC:mah]
synonym: "response to 2-sulfanylethanol" EXACT [CHEBI:41218, GOC:mah]
is_a: GO:0097305 ! response to alcohol
created_by: midori
creation_date: 2012-04-11T03:27:02Z

[Term]
id: GO:0072705
name: cellular response to mercaptoethanol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercaptoethanol stimulus." [CHEBI:41218, GOC:mah]
synonym: "cellular response to 2-sulfanylethanol" EXACT [CHEBI:41218, GOC:mah]
is_a: GO:0072704 ! response to mercaptoethanol
is_a: GO:0097306 ! cellular response to alcohol
created_by: midori
creation_date: 2012-04-11T03:27:40Z

[Term]
id: GO:0072706
name: response to sodium dodecyl sulfate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium dodecyl sulfate (SDS) stimulus." [CHEBI:8984, GOC:mah]
synonym: "response to SDS" EXACT [CHEBI:8984, GOC:mah]
is_a: GO:0010033 ! response to organic substance
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: midori
creation_date: 2012-04-11T03:35:07Z

[Term]
id: GO:0072707
name: cellular response to sodium dodecyl sulfate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium dodecyl sulfate (SDS) stimulus." [CHEBI:8984, GOC:mah]
synonym: "cellular response to SDS" EXACT [CHEBI:8984, GOC:mah]
is_a: GO:0071310 ! cellular response to organic substance
is_a: GO:0072706 ! response to sodium dodecyl sulfate
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: midori
creation_date: 2012-04-11T03:35:15Z

[Term]
id: GO:0072708
name: response to sorbitol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sorbitol stimulus." [CHEBI:30911, GOC:mah]
synonym: "response to glucitol" EXACT [CHEBI:30911, GOC:mah]
is_a: GO:0009743 ! response to carbohydrate
created_by: midori
creation_date: 2012-04-11T03:40:57Z

[Term]
id: GO:0072709
name: cellular response to sorbitol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sorbitol stimulus." [CHEBI:30911, GOC:mah]
synonym: "cellular response to glucitol" EXACT [CHEBI:30911, GOC:mah]
is_a: GO:0071322 ! cellular response to carbohydrate stimulus
is_a: GO:0072708 ! response to sorbitol
created_by: midori
creation_date: 2012-04-11T03:41:03Z

[Term]
id: GO:0072710
name: response to hydroxyurea
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyurea stimulus." [CHEBI:44423, GOC:mah]
synonym: "response to HU" EXACT [GOC:mah]
is_a: GO:0010033 ! response to organic substance
is_a: GO:1901698 ! response to nitrogen compound
created_by: midori
creation_date: 2012-04-11T04:15:42Z

[Term]
id: GO:0072711
name: cellular response to hydroxyurea
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyurea stimulus." [CHEBI:44423, GOC:mah]
synonym: "cellular response to HU" EXACT [GOC:mah]
is_a: GO:0071241 ! cellular response to inorganic substance
is_a: GO:0072710 ! response to hydroxyurea
is_a: GO:1901699 ! cellular response to nitrogen compound
created_by: midori
creation_date: 2012-04-11T04:15:56Z

[Term]
id: GO:0072712
name: response to thiabendazole
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thiabendazole stimulus." [CHEBI:45979, GOC:mah]
synonym: "response to TBZ" EXACT [CHEBI:45979, GOC:mah]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
created_by: midori
creation_date: 2012-04-11T04:23:56Z

[Term]
id: GO:0072713
name: cellular response to thiabendazole
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thiabendazole stimulus." [CHEBI:45979, GOC:mah]
synonym: "cellular response to TBZ" EXACT [CHEBI:45979, GOC:mah]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:0072712 ! response to thiabendazole
created_by: midori
creation_date: 2012-04-11T04:24:19Z

[Term]
id: GO:0072714
name: response to selenite ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a selenite ion stimulus." [CHEBI:18212, GOC:mah]
is_a: GO:0010035 ! response to inorganic substance
created_by: midori
creation_date: 2012-04-19T02:46:28Z

[Term]
id: GO:0072715
name: cellular response to selenite ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a selenite ion stimulus." [CHEBI:18212, GOC:mah]
is_a: GO:0071241 ! cellular response to inorganic substance
is_a: GO:0072714 ! response to selenite ion
created_by: midori
creation_date: 2012-04-19T02:47:50Z

[Term]
id: GO:0072716
name: response to actinomycin D
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an actinomycin D stimulus." [CHEBI:27666, GOC:mah]
is_a: GO:0046677 ! response to antibiotic
is_a: GO:1901652 ! response to peptide
created_by: midori
creation_date: 2012-04-26T02:06:40Z

[Term]
id: GO:0072717
name: cellular response to actinomycin D
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an actinomycin D stimulus." [CHEBI:27666, GOC:mah]
is_a: GO:0071236 ! cellular response to antibiotic
is_a: GO:0072716 ! response to actinomycin D
is_a: GO:1901653 ! cellular response to peptide
created_by: midori
creation_date: 2012-04-26T02:06:55Z

[Term]
id: GO:0072718
name: response to cisplatin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cisplatin stimulus." [CHEBI:27899, GOC:mah]
is_a: GO:1990267 ! response to transition metal nanoparticle
created_by: midori
creation_date: 2012-04-30T11:31:05Z

[Term]
id: GO:0072719
name: cellular response to cisplatin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cisplatin stimulus." [CHEBI:27899, GOC:mah]
is_a: GO:0070887 ! cellular response to chemical stimulus
is_a: GO:0072718 ! response to cisplatin
created_by: midori
creation_date: 2012-04-30T11:31:12Z

[Term]
id: GO:0072720
name: response to dithiothreitol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dithiothreitol stimulus." [CHEBI:18320, GOC:mah]
synonym: "response to 1,4-dithiothreitol" EXACT [CHEBI:18320, GOC:mah]
synonym: "response to DTT" EXACT [GOC:mah]
is_a: GO:0010033 ! response to organic substance
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: midori
creation_date: 2012-05-09T11:08:58Z

[Term]
id: GO:0072721
name: cellular response to dithiothreitol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dithiothreitol stimulus." [CHEBI:18320, GOC:mah]
synonym: "cellular response to 1,4-dithiothreitol" EXACT [CHEBI:18320, GOC:mah]
synonym: "cellular response to DTT" EXACT [GOC:mah]
is_a: GO:0071310 ! cellular response to organic substance
is_a: GO:0072720 ! response to dithiothreitol
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: midori
creation_date: 2012-05-09T11:09:08Z

[Term]
id: GO:0072722
name: response to amitrole
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amitrole stimulus." [CHEBI:40036, GOC:mah]
synonym: "response to 3-amino-1,2,4-triazole" EXACT [CHEBI:40036, GOC:mah]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
created_by: midori
creation_date: 2012-05-31T10:51:45Z

[Term]
id: GO:0072723
name: cellular response to amitrole
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amitrole stimulus." [CHEBI:40036, GOC:mah]
synonym: "cellular response to 3-amino-1,2,4-triazole" EXACT [CHEBI:40036, GOC:mah]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:0072722 ! response to amitrole
created_by: midori
creation_date: 2012-05-31T10:51:52Z

[Term]
id: GO:0072724
name: response to 4-nitroquinoline N-oxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 4-nitroquinoline N-oxide stimulus." [CHEBI:16907, GOC:mah]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: midori
creation_date: 2012-05-31T11:00:37Z

[Term]
id: GO:0072725
name: cellular response to 4-nitroquinoline N-oxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 4-nitroquinoline N-oxide stimulus." [CHEBI:16907, GOC:mah]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:0072724 ! response to 4-nitroquinoline N-oxide
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: midori
creation_date: 2012-05-31T11:00:42Z

[Term]
id: GO:0072726
name: response to CCCP
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a CCCP stimulus." [CHEBI:3259, GOC:mah]
synonym: "response to carbonyl cyanide m-chlorophenyl hydrazone" EXACT [CHEBI:3259, GOC:mah]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
created_by: midori
creation_date: 2012-05-31T11:16:38Z

[Term]
id: GO:0072727
name: cellular response to CCCP
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a CCCP stimulus." [CHEBI:3259, GOC:mah]
synonym: "cellular response to carbonyl cyanide m-chlorophenyl hydrazone" EXACT [CHEBI:3259, GOC:mah]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:0072726 ! response to CCCP
created_by: midori
creation_date: 2012-05-31T11:16:43Z

[Term]
id: GO:0072728
name: response to Gentian violet
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Gentian violet stimulus." [CHEBI:198346, GOC:mah]
synonym: "response to crystal violet" EXACT [GOC:mah]
synonym: "response to {4-[Bis-(4-dimethylamino-phenyl)-methylene]-cyclohexa-2,5-dienylidene}-dimethyl-ammonium chloride" EXACT [CHEBI:198346, GOC:mah]
is_a: GO:0010033 ! response to organic substance
created_by: midori
creation_date: 2012-05-31T11:23:25Z

[Term]
id: GO:0072729
name: cellular response to Gentian violet
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Gentian violet stimulus." [CHEBI:198346, GOC:mah]
synonym: "cellular response to crystal violet" EXACT [GOC:mah]
synonym: "cellular response to {4-[Bis-(4-dimethylamino-phenyl)-methylene]-cyclohexa-2,5-dienylidene}-dimethyl-ammonium chloride" EXACT [CHEBI:198346, GOC:mah]
is_a: GO:0071310 ! cellular response to organic substance
is_a: GO:0072728 ! response to Gentian violet
created_by: midori
creation_date: 2012-05-31T11:23:40Z

[Term]
id: GO:0072730
name: response to papulacandin B
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a papulacandin B stimulus." [CHEBI:569624, GOC:mah]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033993 ! response to lipid
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: midori
creation_date: 2012-05-31T11:30:32Z

[Term]
id: GO:0072731
name: cellular response to papulacandin B
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a papulacandin B stimulus." [CHEBI:569624, GOC:mah]
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0072730 ! response to papulacandin B
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: midori
creation_date: 2012-05-31T11:30:39Z

[Term]
id: GO:0072732
name: cellular response to calcium ion starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of calcium ions." [GOC:mah]
synonym: "cellular response to calcium starvation" EXACT [GOC:mah]
is_a: GO:0009267 ! cellular response to starvation
created_by: midori
creation_date: 2012-07-06T02:42:26Z

[Term]
id: GO:0072733
name: response to staurosporine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a staurosporine stimulus." [CHEBI:15738, GOC:mah]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0043279 ! response to alkaloid
created_by: midori
creation_date: 2012-07-17T10:32:28Z

[Term]
id: GO:0072734
name: cellular response to staurosporine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a staurosporine stimulus." [CHEBI:15738, GOC:mah]
is_a: GO:0071242 ! cellular response to ammonium ion
is_a: GO:0071312 ! cellular response to alkaloid
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0072733 ! response to staurosporine
created_by: midori
creation_date: 2012-07-17T10:33:00Z

[Term]
id: GO:0072735
name: response to t-BOOH
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tert-butyl hydroperoxide (t-BOOH) stimulus." [CHEBI:365419, GOC:mah]
synonym: "response to 2-methyl-prop-2-yl-hydroperoxide" EXACT [CHEBI:365419]
synonym: "response to tert-butyl hydroperoxide" EXACT [GOC:mah]
is_a: GO:0033195 ! response to alkyl hydroperoxide
created_by: midori
creation_date: 2012-07-17T10:33:00Z

[Term]
id: GO:0072736
name: cellular response to t-BOOH
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tert-butyl hydroperoxide (t-BOOH) stimulus." [CHEBI:365419, GOC:mah]
synonym: "cellular response to 2-methyl-prop-2-yl-hydroperoxide" EXACT [CHEBI:365419]
synonym: "cellular response to tert-butyl hydroperoxide" EXACT [GOC:mah]
is_a: GO:0071310 ! cellular response to organic substance
is_a: GO:0071448 ! cellular response to alkyl hydroperoxide
is_a: GO:0072735 ! response to t-BOOH
created_by: midori
creation_date: 2012-07-17T10:33:00Z

[Term]
id: GO:0072737
name: response to diamide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diamide (N,N,N',N'-tetramethyldiazene-1,2-dicarboxamide) stimulus." [CHEBI:48958, GOC:mah]
synonym: "response to N,N,N',N'-tetramethyldiazene-1,2-dicarboxamide" EXACT [CHEBI:48958]
is_a: GO:1901698 ! response to nitrogen compound
created_by: midori
creation_date: 2012-07-17T10:33:00Z

[Term]
id: GO:0072738
name: cellular response to diamide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diamide (N,N,N',N'-tetramethyldiazene-1,2-dicarboxamide) stimulus." [CHEBI:48958, GOC:mah]
synonym: "cellular response to N,N,N',N'-tetramethyldiazene-1,2-dicarboxamide" EXACT [CHEBI:48958]
is_a: GO:0072737 ! response to diamide
is_a: GO:1901699 ! cellular response to nitrogen compound
created_by: midori
creation_date: 2012-07-17T10:33:00Z

[Term]
id: GO:0072739
name: response to anisomycin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anisomycin stimulus." [CHEBI:338412, GOC:mah]
is_a: GO:0010243 ! response to organonitrogen compound
created_by: midori
creation_date: 2012-07-17T10:33:00Z

[Term]
id: GO:0072740
name: cellular response to anisomycin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anisomycin stimulus." [CHEBI:338412, GOC:mah]
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:0072739 ! response to anisomycin
created_by: midori
creation_date: 2012-07-17T10:33:00Z

[Term]
id: GO:0072741
name: protein localization to cell division site
namespace: biological_process
def: "A cellular protein localization process in which a protein is transported to, or maintained at, the site of cell division." [GOC:mah, PMID:19756689]
synonym: "protein localisation to cell division site" EXACT [GOC:mah]
is_a: GO:0034613 ! cellular protein localization
created_by: midori
creation_date: 2012-08-16T11:51:48Z

[Term]
id: GO:0072742
name: SAGA complex localization to transcription regulatory region
namespace: biological_process
def: "Any process in which a SAGA complex is transported to, or maintained in, a specific location in the transcription regulatory region of a gene." [GOC:mah]
synonym: "SAGA complex localization to promoter" EXACT [GOC:mah]
synonym: "SAGA complex recruitment" EXACT [GOC:mah]
is_a: GO:0034629 ! cellular protein complex localization
created_by: midori
creation_date: 2012-08-24T10:36:03Z

[Term]
id: GO:0072743
name: cellular response to erythromycin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythromycin stimulus." [GOC:mah]
is_a: GO:0071242 ! cellular response to ammonium ion
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901323 ! response to erythromycin
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: midori
creation_date: 2012-08-31T12:24:52Z

[Term]
id: GO:0072744
name: cellular response to trichodermin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trichodermin stimulus." [GOC:mah]
is_a: GO:0071362 ! cellular response to ether
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901324 ! response to trichodermin
created_by: midori
creation_date: 2012-08-31T12:29:38Z

[Term]
id: GO:0072745
name: cellular response to antimycin A
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antimycin A stimulus." [GOC:mah]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:1901325 ! response to antimycin A
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: midori
creation_date: 2012-08-31T12:31:08Z

[Term]
id: GO:0072746
name: cellular response to tetracycline
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetracycline stimulus." [GOC:mah]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901326 ! response to tetracycline
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: midori
creation_date: 2012-08-31T12:32:43Z

[Term]
id: GO:0072747
name: cellular response to chloramphenicol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chloramphenicol stimulus." [GOC:mah]
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:1901322 ! response to chloramphenicol
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: midori
creation_date: 2012-08-31T12:33:30Z

[Term]
id: GO:0072748
name: cellular response to tacrolimus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tacrolimus stimulus." [GOC:mah]
synonym: "cellular response to FK506" EXACT [CHEBI:61057]
synonym: "cellular response to tacrolimus hydrate" EXACT [CHEBI:61057]
is_a: GO:0070887 ! cellular response to chemical stimulus
is_a: GO:1901327 ! response to tacrolimus
created_by: midori
creation_date: 2012-08-31T12:34:32Z

[Term]
id: GO:0072749
name: cellular response to cytochalasin B
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytochalasin B stimulus." [GOC:mah]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:1901328 ! response to cytochalasin B
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: midori
creation_date: 2012-08-31T12:37:15Z

[Term]
id: GO:0072750
name: cellular response to leptomycin B
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptomycin B stimulus." [GOC:mah]
is_a: GO:0071398 ! cellular response to fatty acid
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901344 ! response to leptomycin B
created_by: midori
creation_date: 2012-09-10T14:07:32Z

[Term]
id: GO:0072751
name: cellular response to L-thialysine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-thialysine stimulus." [GOC:mah]
synonym: "cellular response to thialysine" BROAD [GOC:mah]
is_a: GO:0071230 ! cellular response to amino acid stimulus
is_a: GO:1901345 ! response to L-thialysine
created_by: midori
creation_date: 2012-09-10T14:12:21Z

[Term]
id: GO:0072752
name: cellular response to rapamycin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rapamycin stimulus." [GOC:TermGenie]
is_a: GO:0071362 ! cellular response to ether
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:0097306 ! cellular response to alcohol
is_a: GO:1901355 ! response to rapamycin
is_a: GO:1901655 ! cellular response to ketone
created_by: midori
creation_date: 2012-09-14T11:13:34Z

[Term]
id: GO:0072753
name: cellular response to glutathione
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glutathione stimulus." [GOC:mah]
is_a: GO:1901370 ! response to glutathione
is_a: GO:1901653 ! cellular response to peptide
created_by: midori
creation_date: 2012-09-25T12:27:39Z

[Term]
id: GO:0072754
name: cellular response to purvalanol A
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purvalanol A stimulus." [GOC:mah]
is_a: GO:0071415 ! cellular response to purine-containing compound
is_a: GO:1901560 ! response to purvalanol A
created_by: midori
creation_date: 2012-11-07T12:05:57Z

[Term]
id: GO:0072755
name: cellular response to benomyl
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benomyl stimulus." [GOC:mah]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:1901561 ! response to benomyl
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: midori
creation_date: 2012-11-07T12:06:58Z

[Term]
id: GO:0072756
name: cellular response to paraquat
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a paraquat stimulus." [GOC:mah]
is_a: GO:0071310 ! cellular response to organic substance
is_a: GO:1901562 ! response to paraquat
created_by: midori
creation_date: 2012-11-07T12:08:59Z

[Term]
id: GO:0072757
name: cellular response to camptothecin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a camptothecin stimulus." [GOC:mah]
synonym: "cellular response to CPT" EXACT [GOC:mah]
is_a: GO:0071312 ! cellular response to alkaloid
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0097306 ! cellular response to alcohol
is_a: GO:1901563 ! response to camptothecin
created_by: midori
creation_date: 2012-11-07T12:12:35Z

[Term]
id: GO:0072758
name: response to topoisomerase inhibitor
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a topoisomerase inhibitor stimulus." [GOC:mah]
is_a: GO:0042221 ! response to chemical
created_by: midori
creation_date: 2012-11-09T11:34:51Z

[Term]
id: GO:0072759
name: cellular response to topoisomerase inhibitor
namespace: biological_process
def: "Any process that results in a change in state or activity of a (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a topoisomerase inhibitor stimulus." [GOC:mah]
is_a: GO:0070887 ! cellular response to chemical stimulus
is_a: GO:0072758 ! response to topoisomerase inhibitor
created_by: midori
creation_date: 2012-11-09T11:38:08Z

[Term]
id: GO:0072760
name: cellular response to GW 7647
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a GW 7647 stimulus." [GOC:mah]
is_a: GO:0071229 ! cellular response to acid chemical
is_a: GO:0071310 ! cellular response to organic substance
is_a: GO:1901593 ! response to GW 7647
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: midori
creation_date: 2012-11-09T11:46:28Z

[Term]
id: GO:0072761
name: cellular response to capsazepine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a capsazepine stimulus." [GOC:mah]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:1901594 ! response to capsazepine
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: midori
creation_date: 2012-11-09T11:47:53Z

[Term]
id: GO:0072762
name: cellular response to carbendazim
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbendazim stimulus." [GOC:mah]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:1901597 ! response to carbendazim
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: midori
creation_date: 2012-11-09T11:48:11Z

[Term]
id: GO:0072763
name: cellular response to hesperadin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hesperadin stimulus." [GOC:mah]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071418 ! cellular response to amine stimulus
is_a: GO:1901595 ! response to hesperadin
created_by: midori
creation_date: 2012-11-09T11:50:58Z

[Term]
id: GO:0072764
name: cellular response to reversine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reversine stimulus." [GOC:mah]
is_a: GO:0071415 ! cellular response to purine-containing compound
is_a: GO:1901596 ! response to reversine
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: midori
creation_date: 2012-11-09T11:52:22Z

[Term]
id: GO:0072765
name: centromere localization
namespace: biological_process
def: "A cellular localization process in which a centromere/kinetochore is transported to, or maintained in, a specific location." [GOC:mah]
synonym: "establishment and maintenance of kinetochore localization" EXACT [GOC:mah]
synonym: "kinetochore localisation" EXACT [GOC:mah]
synonym: "kinetochore localization" EXACT []
is_a: GO:0034629 ! cellular protein complex localization
is_a: GO:0051640 ! organelle localization
created_by: midori
creation_date: 2012-11-21T13:30:53Z

[Term]
id: GO:0072766
name: centromere clustering at the nuclear envelope
namespace: biological_process
def: "A cellular localization process in which kinetochores/centromeres are coupled together at the nuclear periphery. This process is responsible for the Rabl-like configuration of chromosomes in the interphase nuclei. In fission yeast this occurs at a location near the old mitotic spindle pole body." [GOC:mah, GOC:vw, PMID:21965289, PMID:23166349]
synonym: "centromere clustering at the nuclear periphery" EXACT []
synonym: "centromere-SPB clustering" RELATED [GOC:vw, PMID:18158900]
synonym: "kinetochore clustering at SPB" RELATED [GOC:mah]
synonym: "kinetochore clustering at spindle pole body" RELATED []
synonym: "kinetochore clustering at the old mitotic spindle pole body" RELATED []
synonym: "kinetochore localization at spindle pole body" RELATED [GOC:pr]
synonym: "rabl configuration" RELATED [PMID:17881496]
is_a: GO:0098653 ! centromere clustering
relationship: part_of GO:0000278 ! mitotic cell cycle
created_by: midori
creation_date: 2012-11-21T13:32:22Z

[Term]
id: GO:0075000
name: response to host osmotic environment
namespace: biological_process
def: "Any process that results in a change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the osmotic conditions in or around its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "response of symbiont to host osmotic environment" EXACT []
is_a: GO:0075136 ! response to host

[Term]
id: GO:0075001
name: adhesion of symbiont infection structure to host
namespace: biological_process
def: "The attachment of an infection structure of the symbiont to its host via adhesion molecules, general stickiness etc., either directly or indirectly. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products of the symbiont involved in this process.
synonym: "adhesion of symbiont infection structure to host during symbiotic interaction" EXACT []
synonym: "attachment of symbiont infection structure to host" EXACT []
is_a: GO:0044406 ! adhesion of symbiont to host

[Term]
id: GO:0075002
name: adhesion of symbiont germination tube to host
namespace: biological_process
def: "The attachment of a germination tube of the symbiont to its host via adhesion molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "adhesion of symbiont germination tube to host during symbiotic interaction" EXACT []
is_a: GO:0075001 ! adhesion of symbiont infection structure to host

[Term]
id: GO:0075003
name: adhesion of symbiont appressorium to host
namespace: biological_process
def: "The attachment of an appressorium of the symbiont to its host via adhesion molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "adhesion of symbiont appressorium to host during symbiotic interaction" EXACT []
is_a: GO:0075001 ! adhesion of symbiont infection structure to host

[Term]
id: GO:0075004
name: adhesion of symbiont spore to host
namespace: biological_process
def: "The attachment of a spore of the symbiont to its host via adhesion molecules, general stickiness etc. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "adhesion of symbiont spore to host during symbiotic interaction" EXACT []
is_a: GO:0044406 ! adhesion of symbiont to host

[Term]
id: GO:0075005
name: spore germination on or near host
namespace: biological_process
def: "The physiological, developmental and morphological changes that occur in a symbiont spore following release from dormancy up to the earliest signs of growth occurring on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0009847 ! spore germination
is_a: GO:0044132 ! development of symbiont on or near host
is_a: GO:0051701 ! interaction with host

[Term]
id: GO:0075006
name: modulation of spore germination on or near host
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of spore germination on or near host, which is the physiological, developmental and morphological changes that occur in a symbiont spore following release from dormancy up to the earliest signs of growth occurring on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0044138 ! modulation of development of symbiont on or near host
is_a: GO:1904359 ! regulation of spore germination
relationship: regulates GO:0075005 ! spore germination on or near host

[Term]
id: GO:0075007
name: positive regulation of spore germination on or near host
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of spore germination on or near host, which is the physiological, developmental and morphological changes that occur in a symbiont spore following release from dormancy up to the earliest signs of growth occurring on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0044143 ! positive regulation of development of symbiont on or near host surface
is_a: GO:0075006 ! modulation of spore germination on or near host
is_a: GO:1904361 ! positive regulation of spore germination
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0075005 ! spore germination on or near host
relationship: positively_regulates GO:0075005 ! spore germination on or near host

[Term]
id: GO:0075008
name: negative regulation of spore germination on or near host
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of spore germination on or near host, which is the physiological, developmental and morphological changes that occur in a symbiont spore following release from dormancy up to the earliest signs of growth occurring on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0044141 ! negative regulation of development of symbiont on or near host surface
is_a: GO:0075006 ! modulation of spore germination on or near host
is_a: GO:1904360 ! negative regulation of spore germination
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0075005 ! spore germination on or near host
relationship: negatively_regulates GO:0075005 ! spore germination on or near host

[Term]
id: GO:0075009
name: germ tube formation on or near host
namespace: biological_process
def: "Development of slender tubular outgrowth first produced by most symbiont spores immediately following germination on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0044132 ! development of symbiont on or near host
relationship: part_of GO:0075005 ! spore germination on or near host

[Term]
id: GO:0075010
name: modulation of germ tube formation on or near host
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of germ tube formation on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0075006 ! modulation of spore germination on or near host
relationship: regulates GO:0075009 ! germ tube formation on or near host

[Term]
id: GO:0075011
name: positive regulation of germ tube formation on or near host
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of germ tube formation on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0075007 ! positive regulation of spore germination on or near host
is_a: GO:0075010 ! modulation of germ tube formation on or near host
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0075009 ! germ tube formation on or near host
relationship: positively_regulates GO:0075009 ! germ tube formation on or near host

[Term]
id: GO:0075012
name: negative regulation of germ tube formation on or near host
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of germ tube formation on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0075008 ! negative regulation of spore germination on or near host
is_a: GO:0075010 ! modulation of germ tube formation on or near host
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0075009 ! germ tube formation on or near host
relationship: negatively_regulates GO:0075009 ! germ tube formation on or near host

[Term]
id: GO:0075013
name: obsolete growth or development of symbiont on or near host phyllosphere
namespace: biological_process
def: "OBSOLETE. The increase in size or mass of symbiont, or the progression of the symbiont from an initial condition to a later condition, occurring on or near its host phyllosphere. The host phyllosphere is defined as total above-ground surfaces of a plant as a habitat for symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'growth of symbiont on or near host phyllosphere ; GO:0044135' and 'development of symbiont on or near host phyllosphere ; GO:0044134'.
synonym: "growth or development of symbiont on or near host phyllosphere" EXACT []
is_obsolete: true
consider: GO:0044134
consider: GO:0044135

[Term]
id: GO:0075014
name: obsolete growth or development of symbiont on or near host rhizosphere
namespace: biological_process
def: "OBSOLETE. The increase in size or mass of symbiont, or the progression of the symbiont from an initial condition to a later condition, occurring on or near its host rhizosphere. The host rhizosphere is defined as total below-ground surfaces of a plant as a habitat for its symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'growth of symbiont on or near host rhizosphere ; GO:0044137' and 'development of symbiont on or near host rhizosphere ; GO:0044136'.
synonym: "growth or development of symbiont on or near host rhizosphere" EXACT []
is_obsolete: true
consider: GO:0044136
consider: GO:0044137

[Term]
id: GO:0075015
name: formation of infection structure on or near host
namespace: biological_process
def: "The process in which a symbiont structure that serves to infect the host is formed on or near its host organism. It includes physiological, developmental, and morphological changes of the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products of the symbiont involved in this process.
synonym: "formation by symbiont of infection structure on or near host" EXACT []
is_a: GO:0044115 ! development of symbiont involved in interaction with host
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis

[Term]
id: GO:0075016
name: appressorium formation on or near host
namespace: biological_process
def: "The process in which a swollen, flattened portion of a symbiont filament is formed on or near its host organism, to adhere to and for the purpose of penetrating the host surface. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "appressorium formation for entry into host, on or near host" EXACT []
synonym: "formation of an appressorium by symbiont on or near host" EXACT []
is_a: GO:0044134 ! development of symbiont on or near host phyllosphere
is_a: GO:0075015 ! formation of infection structure on or near host

[Term]
id: GO:0075017
name: regulation of appressorium formation on or near host
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of symbiont appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0044138 ! modulation of development of symbiont on or near host
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0075016 ! appressorium formation on or near host
relationship: regulates GO:0075016 ! appressorium formation on or near host

[Term]
id: GO:0075018
name: positive regulation of appressorium formation on or near host
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of symbiont appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0044143 ! positive regulation of development of symbiont on or near host surface
is_a: GO:0075017 ! regulation of appressorium formation on or near host
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0075016 ! appressorium formation on or near host
relationship: positively_regulates GO:0075016 ! appressorium formation on or near host

[Term]
id: GO:0075019
name: negative regulation of appressorium formation on or near host
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0044141 ! negative regulation of development of symbiont on or near host surface
is_a: GO:0075017 ! regulation of appressorium formation on or near host
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0075016 ! appressorium formation on or near host
relationship: negatively_regulates GO:0075016 ! appressorium formation on or near host

[Term]
id: GO:0075020
name: calcium or calmodulin-mediated activation of appressorium formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of symbiont calcium or calmodulin-mediated signal transduction during appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "Ca++ or calmodulin-mediated activation of appressorium formation" EXACT []
synonym: "Ca2+ or calmodulin-mediated activation of appressorium formation" EXACT []
is_a: GO:0075018 ! positive regulation of appressorium formation on or near host

[Term]
id: GO:0075021
name: cAMP-mediated activation of appressorium formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of symbiont cAMP mediated signal transduction during appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "cyclic AMP mediated activation of appressorium formation" EXACT []
is_a: GO:0075018 ! positive regulation of appressorium formation on or near host

[Term]
id: GO:0075022
name: ethylene-mediated activation of appressorium formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of symbiont ethylene-mediated signal transduction during appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0075018 ! positive regulation of appressorium formation on or near host

[Term]
id: GO:0075023
name: MAPK-mediated regulation of appressorium formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of symbiont MAP kinase-mediated signal transduction during appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "mitogen-activated protein kinase-mediated activation of appressorium formation" EXACT []
is_a: GO:0075018 ! positive regulation of appressorium formation on or near host

[Term]
id: GO:0075024
name: phospholipase C-mediated activation of appressorium formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of symbiont phospholipase C-mediated signal transduction during appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0075018 ! positive regulation of appressorium formation on or near host

[Term]
id: GO:0075025
name: initiation of appressorium on or near host
namespace: biological_process
def: "The process in which a relatively unspecialized cell starts to acquire specialized features of the symbiont appressorium to aid in infection of the host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "appressorium initiation on or near host" EXACT []
synonym: "initiation of appressorium by symbiont on or near host" EXACT []
synonym: "initiation of symbiont appressorium on or near host" EXACT []
is_a: GO:0044111 ! development involved in symbiotic interaction
relationship: part_of GO:0075016 ! appressorium formation on or near host

[Term]
id: GO:0075026
name: regulation of appressorium initiation on or near host
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of symbiont appressorium initiation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "regulation of initiation of appressorium on or near host" EXACT []
is_a: GO:0075017 ! regulation of appressorium formation on or near host
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0075025 ! initiation of appressorium on or near host
relationship: regulates GO:0075025 ! initiation of appressorium on or near host

[Term]
id: GO:0075027
name: positive regulation of appressorium initiation on or near host
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of symbiont appressorium initiation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "positive regulation of initiation of appressorium on or near host" EXACT []
is_a: GO:0075018 ! positive regulation of appressorium formation on or near host
is_a: GO:0075026 ! regulation of appressorium initiation on or near host
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0075025 ! initiation of appressorium on or near host
relationship: positively_regulates GO:0075025 ! initiation of appressorium on or near host

[Term]
id: GO:0075028
name: negative regulation of appressorium initiation on or near host
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent symbiont appressorium initiation near or on host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "negative regulation of initiation of appressorium on or near host" EXACT []
is_a: GO:0075019 ! negative regulation of appressorium formation on or near host
is_a: GO:0075026 ! regulation of appressorium initiation on or near host
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0075025 ! initiation of appressorium on or near host
relationship: negatively_regulates GO:0075025 ! initiation of appressorium on or near host

[Term]
id: GO:0075029
name: formation of symbiont germ tube hook structure on or near host
namespace: biological_process
def: "The development of a swollen tip at the growing end of a symbiont spore which usually flattens against the host cell surface prior to appressorium formation. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "formation of germ tube tip of symbiont on or near the exterior of host" EXACT []
synonym: "symbiont germ tube hook structure formation on or near host" EXACT []
is_a: GO:0075015 ! formation of infection structure on or near host
relationship: part_of GO:0075025 ! initiation of appressorium on or near host

[Term]
id: GO:0075030
name: modulation of symbiont germ tube hook structure formation on or near host
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of symbiont germ tube hook structure formation on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "modulation of germ tube tip of symbiont on or near the exterior of host" EXACT []
synonym: "regulation of formation of symbiont germ tube hook structure on or near host" EXACT []
is_a: GO:0075026 ! regulation of appressorium initiation on or near host
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0075029 ! formation of symbiont germ tube hook structure on or near host
relationship: regulates GO:0075029 ! formation of symbiont germ tube hook structure on or near host

[Term]
id: GO:0075031
name: positive regulation of symbiont germ tube hook structure formation on or near host
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of symbiont germ tube hook structure formation on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "positive regulation of formation of symbiont germ tube hook structure on or near host" EXACT []
synonym: "positive regulation of germ tube tip of symbiont on or near the exterior of host" EXACT []
is_a: GO:0075027 ! positive regulation of appressorium initiation on or near host
is_a: GO:0075030 ! modulation of symbiont germ tube hook structure formation on or near host
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0075029 ! formation of symbiont germ tube hook structure on or near host
relationship: positively_regulates GO:0075029 ! formation of symbiont germ tube hook structure on or near host

[Term]
id: GO:0075032
name: negative regulation of symbiont germ tube hook structure formation on or near host
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont germ tube hook structure formation on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "negative regulation of formation of symbiont germ tube hook structure on or near host" EXACT []
synonym: "negative regulation of germ tube tip of symbiont on or near the exterior of host" EXACT []
is_a: GO:0075028 ! negative regulation of appressorium initiation on or near host
is_a: GO:0075030 ! modulation of symbiont germ tube hook structure formation on or near host
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0075029 ! formation of symbiont germ tube hook structure on or near host
relationship: negatively_regulates GO:0075029 ! formation of symbiont germ tube hook structure on or near host

[Term]
id: GO:0075033
name: septum formation involved in appressorium formation on or near host
namespace: biological_process
def: "The process in which a symbiont partition is formed to separate the appressorium from the germination tube, occurring on or near the exterior of its host organism during appressorium formation. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "septum formation during appressorium formation on or near host" RELATED [GOC:tb]
is_a: GO:0044132 ! development of symbiont on or near host
relationship: part_of GO:0075016 ! appressorium formation on or near host

[Term]
id: GO:0075034
name: nuclear division involved in appressorium formation on or near host
namespace: biological_process
def: "The process in which nuclear division occurs within a symbiont spore that contributes to appressorium formation on or near the exterior of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:dph, GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "nuclear division during appressorium formation on or near host" RELATED [GOC:dph]
is_a: GO:0000280 ! nuclear division
intersection_of: GO:0000280 ! nuclear division
intersection_of: part_of GO:0075016 ! appressorium formation on or near host
relationship: part_of GO:0075016 ! appressorium formation on or near host

[Term]
id: GO:0075035
name: maturation of appressorium on or near host
namespace: biological_process
def: "The process in which specialized features of the symbiont appressorium are acquired post initiation, to aid in infection of the host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "appressorium maturation on or near host" EXACT []
synonym: "maturation of symbiont appressorium on or near host" EXACT []
is_a: GO:0044115 ! development of symbiont involved in interaction with host
relationship: part_of GO:0075016 ! appressorium formation on or near host

[Term]
id: GO:0075036
name: regulation of appressorium maturation on or near host
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of symbiont appressorium maturation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "regulation of maturation of appressorium on or near host" EXACT []
is_a: GO:0075017 ! regulation of appressorium formation on or near host
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0075035 ! maturation of appressorium on or near host
relationship: regulates GO:0075035 ! maturation of appressorium on or near host

[Term]
id: GO:0075037
name: positive regulation of appressorium maturation on or near host
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of symbiont appressorium maturation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "positive regulation maturation of appressorium on or near host" EXACT []
is_a: GO:0075018 ! positive regulation of appressorium formation on or near host
is_a: GO:0075036 ! regulation of appressorium maturation on or near host
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0075035 ! maturation of appressorium on or near host
relationship: positively_regulates GO:0075035 ! maturation of appressorium on or near host

[Term]
id: GO:0075038
name: negative regulation of appressorium maturation on or near host
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent symbiont appressorium maturation in, near or on host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "negative regulation of maturation of appressorium on or near host" EXACT []
is_a: GO:0075019 ! negative regulation of appressorium formation on or near host
is_a: GO:0075036 ! regulation of appressorium maturation on or near host
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0075035 ! maturation of appressorium on or near host
relationship: negatively_regulates GO:0075035 ! maturation of appressorium on or near host

[Term]
id: GO:0075039
name: establishment of turgor in appressorium
namespace: biological_process
def: "The process in which hydrostatic pressure is increased within the symbiont appressorium to breach the cuticle of the host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "establishment of turgor in symbiont appressorium on or near host" EXACT []
synonym: "formation of turgor in appressorium" EXACT []
synonym: "generation of turgor in appressorium" EXACT []
is_a: GO:0044115 ! development of symbiont involved in interaction with host
relationship: part_of GO:0075035 ! maturation of appressorium on or near host

[Term]
id: GO:0075040
name: regulation of establishment of turgor in appressorium
namespace: biological_process
def: "Any process modulates the frequency, rate or extent of turgor formation in the symbiont appressorium on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "regulation of turgor formation in appressorium" RELATED []
is_a: GO:0075036 ! regulation of appressorium maturation on or near host
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0075039 ! establishment of turgor in appressorium
relationship: regulates GO:0075039 ! establishment of turgor in appressorium

[Term]
id: GO:0075041
name: positive regulation of establishment of turgor in appressorium
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of turgor formation in the symbiont appressorium on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0075037 ! positive regulation of appressorium maturation on or near host
is_a: GO:0075040 ! regulation of establishment of turgor in appressorium
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0075039 ! establishment of turgor in appressorium
relationship: positively_regulates GO:0075039 ! establishment of turgor in appressorium

[Term]
id: GO:0075042
name: negative regulation of establishment of turgor in appressorium
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of turgor formation in the symbiont appressorium on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0075038 ! negative regulation of appressorium maturation on or near host
is_a: GO:0075040 ! regulation of establishment of turgor in appressorium
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0075039 ! establishment of turgor in appressorium
relationship: negatively_regulates GO:0075039 ! establishment of turgor in appressorium

[Term]
id: GO:0075043
name: maintenance of turgor in appressorium by melanization
namespace: biological_process
def: "The process in which melanin is produced in the appressorium of the symbiont on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "melanization of appressorium to maintain turgor pressure" EXACT []
is_a: GO:0042438 ! melanin biosynthetic process
is_a: GO:0075040 ! regulation of establishment of turgor in appressorium

[Term]
id: GO:0075044
name: autophagy of host cells involved in interaction with symbiont
namespace: biological_process
def: "The process in which the host cells digest parts of their own cytoplasm during interaction with its symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should be used to annotate gene products of host.
synonym: "autophagy of host cells during interaction with symbiont" RELATED [GOC:dph]
is_a: GO:0075071 ! autophagy involved in symbiotic interaction

[Term]
id: GO:0075045
name: regulation of formation by symbiont of haustorium for nutrient acquisition from host
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of symbiont haustorium formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0044127 ! regulation of development of symbiont in host
is_a: GO:0060259 ! regulation of feeding behavior
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0052094 ! formation by symbiont of haustorium for nutrient acquisition from host
relationship: regulates GO:0052094 ! formation by symbiont of haustorium for nutrient acquisition from host

[Term]
id: GO:0075046
name: positive regulation of formation by symbiont of haustorium for nutrient acquisition from host
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of symbiont haustorium formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0044129 ! positive regulation of development of symbiont in host
is_a: GO:0075045 ! regulation of formation by symbiont of haustorium for nutrient acquisition from host
is_a: GO:2000253 ! positive regulation of feeding behavior
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0052094 ! formation by symbiont of haustorium for nutrient acquisition from host
relationship: positively_regulates GO:0052094 ! formation by symbiont of haustorium for nutrient acquisition from host

[Term]
id: GO:0075047
name: negative regulation of formation by symbiont of haustorium for nutrient acquisition from host
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont haustorium formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0044131 ! negative regulation of development of symbiont in host
is_a: GO:0075045 ! regulation of formation by symbiont of haustorium for nutrient acquisition from host
is_a: GO:2000252 ! negative regulation of feeding behavior
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0052094 ! formation by symbiont of haustorium for nutrient acquisition from host
relationship: negatively_regulates GO:0052094 ! formation by symbiont of haustorium for nutrient acquisition from host

[Term]
id: GO:0075048
name: cell wall strengthening in symbiont involved in entry into host
namespace: biological_process
def: "A process in which the cell wall of the symbiont is strengthened or thickened during penetration into the body, tissues, or cells of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "cell wall strengthening in symbiont during entry into host" RELATED [GOC:tb]
synonym: "cell wall thickening in symbiont during entry into host" RELATED []
synonym: "symbiont cell wall strengthening during entry into host" RELATED []
is_a: GO:0052386 ! cell wall thickening
relationship: part_of GO:0044409 ! entry into host

[Term]
id: GO:0075049
name: modulation of symbiont cell wall strengthening involved in entry into host
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of symbiont cell wall strengthening during entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "modulation of symbiont cell wall strengthening during entry into host" RELATED [GOC:tb]
is_a: GO:0051128 ! regulation of cellular component organization
is_a: GO:0052372 ! modulation by symbiont of entry into host
is_a: GO:1903338 ! regulation of cell wall organization or biogenesis
relationship: regulates GO:0075048 ! cell wall strengthening in symbiont involved in entry into host

[Term]
id: GO:0075050
name: positive regulation of symbiont cell wall strengthening involved in entry into host
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of symbiont cell wall strengthening during entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "positive regulation of symbiont cell wall strengthening during entry into host" RELATED [GOC:tb]
is_a: GO:0040017 ! positive regulation of locomotion
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:0075049 ! modulation of symbiont cell wall strengthening involved in entry into host
is_a: GO:0075294 ! positive regulation by symbiont of entry into host
is_a: GO:1903340 ! positive regulation of cell wall organization or biogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0075048 ! cell wall strengthening in symbiont involved in entry into host
relationship: positively_regulates GO:0075048 ! cell wall strengthening in symbiont involved in entry into host

[Term]
id: GO:0075051
name: negative regulation of symbiont cell wall strengthening involved in entry into host
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont cell wall strengthening during entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "negative regulation of symbiont cell wall strengthening during entry into host" RELATED [GOC:tb]
is_a: GO:0040013 ! negative regulation of locomotion
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:0052374 ! negative regulation by symbiont of entry into host
is_a: GO:0075049 ! modulation of symbiont cell wall strengthening involved in entry into host
is_a: GO:1903339 ! negative regulation of cell wall organization or biogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0075048 ! cell wall strengthening in symbiont involved in entry into host
relationship: negatively_regulates GO:0075048 ! cell wall strengthening in symbiont involved in entry into host

[Term]
id: GO:0075052
name: entry into host via a specialized structure
namespace: biological_process
def: "Penetration via a specialized structure of symbiont into the body, tissues, or cells of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "entry into host via a specialized structure during symbiotic interaction" EXACT []
is_a: GO:0044409 ! entry into host

[Term]
id: GO:0075053
name: formation of symbiont penetration peg for entry into host
namespace: biological_process
def: "The assembly by the symbiont of a peg-like structure for the purpose of penetration into its host organism, which penetrates through the host cuticle and epidermal cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "symbiont penetration peg formation for entry into host" EXACT []
is_a: GO:0075015 ! formation of infection structure on or near host
relationship: part_of GO:0075052 ! entry into host via a specialized structure

[Term]
id: GO:0075054
name: modulation of symbiont penetration peg formation for entry into host
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of symbiont penetration peg formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0044145 ! modulation of development of symbiont involved in interaction with host
is_a: GO:0052372 ! modulation by symbiont of entry into host
relationship: regulates GO:0075053 ! formation of symbiont penetration peg for entry into host

[Term]
id: GO:0075055
name: positive regulation of symbiont penetration peg formation for entry into host
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of symbiont penetration peg formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0040017 ! positive regulation of locomotion
is_a: GO:0044149 ! positive regulation of development of symbiont involved in interaction with host
is_a: GO:0075054 ! modulation of symbiont penetration peg formation for entry into host
is_a: GO:0075294 ! positive regulation by symbiont of entry into host
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0075053 ! formation of symbiont penetration peg for entry into host
relationship: positively_regulates GO:0075053 ! formation of symbiont penetration peg for entry into host

[Term]
id: GO:0075056
name: negative regulation of symbiont penetration peg formation for entry into host
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont penetration peg formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0040013 ! negative regulation of locomotion
is_a: GO:0044147 ! negative regulation of development of symbiont involved in interaction with host
is_a: GO:0052374 ! negative regulation by symbiont of entry into host
is_a: GO:0075054 ! modulation of symbiont penetration peg formation for entry into host
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0075053 ! formation of symbiont penetration peg for entry into host
relationship: negatively_regulates GO:0075053 ! formation of symbiont penetration peg for entry into host

[Term]
id: GO:0075057
name: initiation of symbiont penetration peg
namespace: biological_process
def: "The process in which a relatively unspecialized cell of the symbiont starts to acquire the characteristics of a mature penetration peg to penetrate into its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "symbiont penetration peg initiation" EXACT []
is_a: GO:0044111 ! development involved in symbiotic interaction
relationship: part_of GO:0075053 ! formation of symbiont penetration peg for entry into host

[Term]
id: GO:0075058
name: modulation of symbiont penetration peg initiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of penetration peg initiation, the process in which a relatively unspecialized cell start to acquire the characteristics of a mature penetration peg when the symbiont penetrates its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0075054 ! modulation of symbiont penetration peg formation for entry into host
relationship: regulates GO:0075057 ! initiation of symbiont penetration peg

[Term]
id: GO:0075059
name: positive regulation of symbiont penetration peg initiation
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of symbiont penetration peg initiation, the process in which a relatively unspecialized cell starts to acquire the characteristics of a mature penetration peg during the symbiont penetrating into its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0075055 ! positive regulation of symbiont penetration peg formation for entry into host
is_a: GO:0075058 ! modulation of symbiont penetration peg initiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0075057 ! initiation of symbiont penetration peg
relationship: positively_regulates GO:0075057 ! initiation of symbiont penetration peg

[Term]
id: GO:0075060
name: negative regulation of symbiont penetration peg initiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont penetration peg initiation, the process in which a relatively unspecialized cell starts to acquire the characteristics of a mature penetration peg during the symbiont penetrating into its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0075056 ! negative regulation of symbiont penetration peg formation for entry into host
is_a: GO:0075058 ! modulation of symbiont penetration peg initiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0075057 ! initiation of symbiont penetration peg
relationship: negatively_regulates GO:0075057 ! initiation of symbiont penetration peg

[Term]
id: GO:0075061
name: formation of symbiont invasive hypha in host
namespace: biological_process
def: "The assembly by the symbiont of a threadlike, tubular structure, which may contain multiple nuclei and may or may not be divided internally by septa or cross-walls, for the purpose of invasive growth within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "formation of symbiont invasive hypha within host" EXACT []
synonym: "formation of symbiont invasive hypha within host during symbiotic interaction" EXACT []
synonym: "symbiont invasive hypha formation within host" EXACT []
is_a: GO:0044114 ! development of symbiont in host

[Term]
id: GO:0075062
name: regulation of symbiont invasive hypha formation in host
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of symbiont invasive hypha formation within host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "regulation of symbiont invasive hypha formation within host" EXACT []
is_a: GO:0044127 ! regulation of development of symbiont in host
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0075061 ! formation of symbiont invasive hypha in host
relationship: regulates GO:0075061 ! formation of symbiont invasive hypha in host

[Term]
id: GO:0075063
name: positive regulation of symbiont invasive hypha formation in host
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of symbiont invasive hypha formation within host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "positive regulation of symbiont invasive hypha formation within host" EXACT []
is_a: GO:0044129 ! positive regulation of development of symbiont in host
is_a: GO:0075062 ! regulation of symbiont invasive hypha formation in host
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0075061 ! formation of symbiont invasive hypha in host
relationship: positively_regulates GO:0075061 ! formation of symbiont invasive hypha in host

[Term]
id: GO:0075064
name: negative regulation of symbiont invasive hypha formation in host
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont invasive hypha formation within host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "negative regulation of symbiont invasive hypha formation within host" EXACT []
is_a: GO:0044131 ! negative regulation of development of symbiont in host
is_a: GO:0075062 ! regulation of symbiont invasive hypha formation in host
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0075061 ! formation of symbiont invasive hypha in host
relationship: negatively_regulates GO:0075061 ! formation of symbiont invasive hypha in host

[Term]
id: GO:0075065
name: obsolete growth or development of symbiont in host cell
namespace: biological_process
def: "OBSOLETE. The increase in size or mass of symbiont, or the progression of the symbiont from an initial condition to a later condition, occurring in its host's cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'development of symbiont in host cell ; GO:0044118' and 'growth of symbiont in host cell ; GO:0044119'.
synonym: "growth or development of symbiont in host cell" EXACT []
is_obsolete: true
consider: GO:0044118
consider: GO:0044119

[Term]
id: GO:0075066
name: obsolete growth or development of symbiont in host organelle
namespace: biological_process
def: "OBSOLETE. The increase in size or mass of symbiont, or the progression of the symbiont from an initial condition to a later condition, occurring in its host's organelle. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'development of symbiont in host organelle ; GO:0044120' and 'growth of symbiont in host organelle ; GO:0044121'.
synonym: "growth or development of symbiont in host organelle" EXACT []
is_obsolete: true
consider: GO:0044120
consider: GO:0044121

[Term]
id: GO:0075067
name: obsolete growth or development of symbiont in host intercellular space
namespace: biological_process
def: "OBSOLETE. The increase in size or mass of symbiont, or the progression of the symbiont from an initial condition to a later condition, occurring in its host's intercellular space. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'development during symbiotic interaction ; GO:0044111' and 'growth of symbiont in host intercellular space ; GO:0044125'.
synonym: "growth or development of symbiont in host intercellular space" EXACT []
is_obsolete: true
consider: GO:0044124
consider: GO:0044125

[Term]
id: GO:0075068
name: obsolete growth or development of symbiont in host vascular tissue
namespace: biological_process
def: "OBSOLETE. The increase in size or mass of symbiont, or the progression of the symbiont from an initial condition to a later condition, occurring in its host's vascular tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'development of symbiont in host vascular tissue ; GO:0044122' and 'growth of symbiont in host vascular tissue ; GO:0044123'.
synonym: "growth or development of symbiont in host vascular tissue" EXACT []
is_obsolete: true
consider: GO:0044122
consider: GO:0044123

[Term]
id: GO:0075069
name: adhesion of symbiont infection cushion to host
namespace: biological_process
def: "The attachment of an infection cushion of the symbiont to its host via adhesion molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "adhesion of symbiont infection cushion to host during symbiotic interaction" EXACT []
is_a: GO:0075001 ! adhesion of symbiont infection structure to host

[Term]
id: GO:0075070
name: adhesion of symbiont hyphopodium to host
namespace: biological_process
def: "The attachment of a hyphopodium of the symbiont to its host via adhesion molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "adhesion of symbiont hyphopodium to host during symbiotic interaction" EXACT []
is_a: GO:0075001 ! adhesion of symbiont infection structure to host

[Term]
id: GO:0075071
name: autophagy involved in symbiotic interaction
namespace: biological_process
def: "The process in which cells digest parts of their own cytoplasm during a symbiotic interaction; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should be used to annotate gene products of the organism involved in this process.
synonym: "autophagy during symbiotic interaction" RELATED [GOC:dph]
is_a: GO:0006914 ! autophagy
intersection_of: GO:0006914 ! autophagy
intersection_of: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism
relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism

[Term]
id: GO:0075072
name: autophagy of symbiont cells involved in interaction with host
namespace: biological_process
def: "The process in which symbiont cells digest parts of their own cytoplasm during interaction with its host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should be used to annotate gene products of symbiont.
synonym: "autophagy of symbiont cells during interaction with host" RELATED [GOC:dph]
is_a: GO:0075071 ! autophagy involved in symbiotic interaction
relationship: part_of GO:0051701 ! interaction with host

[Term]
id: GO:0075073
name: autophagy of symbiont cells on or near host surface
namespace: biological_process
def: "The process in which symbiont cells digest parts of their own cytoplasm, occurring when the symbiont is on or near its host surface. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should be used to annotate gene products of symbiont.
is_a: GO:0075072 ! autophagy of symbiont cells involved in interaction with host

[Term]
id: GO:0075074
name: spore autophagy involved in appressorium formation on or near host
namespace: biological_process
def: "The process in which a symbiont spore digests parts of its own cytoplasm, occurring when the appressorium forms on or near the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "autophagy of spores during appressorium formation on or near host" EXACT []
synonym: "spore autophagy during appressorium formation on or near host" RELATED [GOC:tb]
is_a: GO:0075073 ! autophagy of symbiont cells on or near host surface
relationship: part_of GO:0075016 ! appressorium formation on or near host

[Term]
id: GO:0075075
name: modulation by host of symbiont adenylate cyclase activity
namespace: biological_process
def: "Any process in which the host organism modulates the frequency, rate or extent of the symbiont adenylate cyclase activity, which catalyze the reaction: ATP = 3',5'-cyclic AMP + diphosphate. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "modulation by symbiont of host adenylate cyclase activity ; GO:0075106".
is_a: GO:0045761 ! regulation of adenylate cyclase activity
is_a: GO:0052422 ! modulation by host of symbiont catalytic activity

[Term]
id: GO:0075076
name: positive regulation by host of symbiont adenylate cyclase activity
namespace: biological_process
def: "Any process in which the host organism activates, maintains or increases the frequency, rate or extent of the symbiont adenylate cyclase activity, which catalyze the reaction: ATP = 3',5'-cyclic AMP + diphosphate. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "positive regulation by symbiont of host adenylate cyclase activity ; GO:0075107".
is_a: GO:0043947 ! positive regulation by host of symbiont catalytic activity
is_a: GO:0045762 ! positive regulation of adenylate cyclase activity
is_a: GO:0075075 ! modulation by host of symbiont adenylate cyclase activity

[Term]
id: GO:0075077
name: negative regulation by host of symbiont adenylate cyclase activity
namespace: biological_process
def: "Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of the symbiont adenylate cyclase activity, which catalyze the reaction: ATP = 3',5'-cyclic AMP + diphosphate. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "negative regulation by symbiont of host adenylate cyclase activity ; GO:0075108".
is_a: GO:0007194 ! negative regulation of adenylate cyclase activity
is_a: GO:0052403 ! negative regulation by host of symbiont catalytic activity
is_a: GO:0075075 ! modulation by host of symbiont adenylate cyclase activity

[Term]
id: GO:0075078
name: modulation by host of symbiont receptor-mediated signal transduction
namespace: biological_process
def: "Any process in which the host organism modulates the frequency, rate or extent of receptor-mediated signal transduction in the symbiont. The receptor is defined as a protein on the cell membrane or within the cytoplasm or cell nucleus that binds to a specific molecule (a ligand) such as a neurotransmitter or a hormone or other substance, and initiates the cellular response to the ligand. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "modulation by symbiont of host receptor-mediated signal transduction ; GO:0075109".
is_a: GO:0052470 ! modulation by host of symbiont signal transduction pathway

[Term]
id: GO:0075079
name: positive regulation by host of symbiont receptor-mediated signal transduction
namespace: biological_process
def: "Any process in which the host organism activates, maintains or increases the frequency, rate or extent of receptor-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "positive regulation by symbiont of host receptor-mediated signal transduction ; GO:0075110".
is_a: GO:0075078 ! modulation by host of symbiont receptor-mediated signal transduction

[Term]
id: GO:0075080
name: negative regulation by host of symbiont receptor-mediated signal transduction
namespace: biological_process
def: "Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of receptor-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "negative regulation by symbiont of host receptor-mediated signal transduction ; GO:0075111".
is_a: GO:0075078 ! modulation by host of symbiont receptor-mediated signal transduction

[Term]
id: GO:0075081
name: modulation by host of symbiont transmembrane receptor-mediated signal transduction
namespace: biological_process
def: "Any process in which the host organism modulates the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "modulation by symbiont of host transmembrane receptor-mediated signal transduction ; GO:0075112".
is_a: GO:0075078 ! modulation by host of symbiont receptor-mediated signal transduction

[Term]
id: GO:0075082
name: positive regulation by host of symbiont transmembrane receptor-mediated signal transduction
namespace: biological_process
def: "Any process in which the host organism activates, maintains or increases the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "positive regulation by symbiont of host transmembrane receptor-mediated signal transduction ; GO:0075113".
is_a: GO:0075079 ! positive regulation by host of symbiont receptor-mediated signal transduction
is_a: GO:0075081 ! modulation by host of symbiont transmembrane receptor-mediated signal transduction

[Term]
id: GO:0075083
name: negative regulation by host of symbiont transmembrane receptor-mediated signal transduction
namespace: biological_process
def: "Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "negative regulation by symbiont of host transmembrane receptor-mediated signal transduction ; GO:0075114".
is_a: GO:0075080 ! negative regulation by host of symbiont receptor-mediated signal transduction
is_a: GO:0075081 ! modulation by host of symbiont transmembrane receptor-mediated signal transduction

[Term]
id: GO:0075084
name: modulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction
namespace: biological_process
def: "Any process in which the host organism modulates the frequency, rate or extent of transmembrane receptor-mediated cAMP signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "modulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction ; GO:0075115".
synonym: "modulation by host of symbiont transmembrane receptor-mediated cAMP signaling" EXACT []
is_a: GO:0075081 ! modulation by host of symbiont transmembrane receptor-mediated signal transduction
is_a: GO:0075205 ! modulation by host of symbiont cAMP-mediated signal transduction

[Term]
id: GO:0075085
name: positive regulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction
namespace: biological_process
def: "Any process in which the host organism activates, maintains or increases the frequency, rate or extent of transmembrane receptor-mediated cAMP signal transduction in the symbiont organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "positive regulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction ; GO:0075116".
synonym: "activation by host of symbiont transmembrane receptor-mediated cAMP signal transduction" NARROW []
synonym: "positive regulation by host of symbiont transmembrane receptor-mediated cAMP signaling" EXACT []
synonym: "promotion by host of symbiont transmembrane receptor protein activity involved in cAMP-mediated signal transduction" EXACT []
synonym: "stimulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction" NARROW []
synonym: "upregulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction" EXACT []
is_a: GO:0075082 ! positive regulation by host of symbiont transmembrane receptor-mediated signal transduction
is_a: GO:0075084 ! modulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction
is_a: GO:0075206 ! positive regulation by host of symbiont cAMP-mediated signal transduction

[Term]
id: GO:0075086
name: negative regulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction
namespace: biological_process
def: "Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of transmembrane receptor-mediated cAMP signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "negative regulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction ; GO:0075117".
synonym: "downregulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction" EXACT []
synonym: "inhibition by host of symbiont transmembrane receptor-mediated cAMP signal transduction" NARROW []
synonym: "negative regulation by host of symbiont transmembrane receptor-mediated cAMP signaling" EXACT []
is_a: GO:0075083 ! negative regulation by host of symbiont transmembrane receptor-mediated signal transduction
is_a: GO:0075084 ! modulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction
is_a: GO:0075207 ! negative regulation by host of symbiont cAMP-mediated signal transduction

[Term]
id: GO:0075087
name: modulation by host of symbiont G-protein coupled receptor protein signal transduction
namespace: biological_process
def: "Any process in which the host organism modulates the frequency, rate or extent of the symbiont G-protein coupled receptor protein signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "modulation by symbiont of host G-protein coupled receptor protein signal transduction ; GO:0075118".
is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:0075081 ! modulation by host of symbiont transmembrane receptor-mediated signal transduction

[Term]
id: GO:0075088
name: positive regulation by host of symbiont G-protein coupled receptor protein signal transduction
namespace: biological_process
def: "Any process in which the host organism activates, maintains or increases the frequency, rate or extent of the symbiont G-protein coupled receptor protein signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "positive regulation by symbiont of host G-protein coupled receptor protein signal transduction ; GO:0075119".
is_a: GO:0045745 ! positive regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:0075082 ! positive regulation by host of symbiont transmembrane receptor-mediated signal transduction
is_a: GO:0075087 ! modulation by host of symbiont G-protein coupled receptor protein signal transduction

[Term]
id: GO:0075089
name: negative regulation by host of symbiont G-protein coupled receptor protein signal transduction
namespace: biological_process
def: "Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of the symbiont G-protein coupled receptor protein signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "negative regulation by symbiont of host G-protein coupled receptor protein signal transduction ; GO:0075120".
is_a: GO:0045744 ! negative regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:0075083 ! negative regulation by host of symbiont transmembrane receptor-mediated signal transduction
is_a: GO:0075087 ! modulation by host of symbiont G-protein coupled receptor protein signal transduction

[Term]
id: GO:0075090
name: modulation by host of symbiont signal transduction mediated by G-protein alpha subunit
namespace: biological_process
def: "Any process in which the host organism modulates the frequency, rate or extent of the symbiont signal transduction mediated by G-protein alpha subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "modulation by symbiont of host signal transduction mediated by G-protein alpha subunit ; GO:0075121".
is_a: GO:0075087 ! modulation by host of symbiont G-protein coupled receptor protein signal transduction

[Term]
id: GO:0075091
name: positive regulation by host of symbiont signal transduction mediated by G-protein alpha subunit
namespace: biological_process
def: "Any process in which the host organism activates, maintains or increases the frequency, rate or extent of the symbiont signal transduction mediated by G-protein alpha subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "positive regulation by symbiont of host signal transduction mediated by G-protein alpha subunit ; GO:0075122".
is_a: GO:0075088 ! positive regulation by host of symbiont G-protein coupled receptor protein signal transduction
is_a: GO:0075090 ! modulation by host of symbiont signal transduction mediated by G-protein alpha subunit

[Term]
id: GO:0075092
name: negative regulation by host of symbiont signal transduction mediated by G-protein alpha subunit
namespace: biological_process
def: "Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of the symbiont signal transduction mediated by G-protein alpha subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "negative regulation by symbiont of host signal transduction mediated by G-protein alpha subunit ; GO:0075123".
is_a: GO:0075089 ! negative regulation by host of symbiont G-protein coupled receptor protein signal transduction
is_a: GO:0075090 ! modulation by host of symbiont signal transduction mediated by G-protein alpha subunit

[Term]
id: GO:0075093
name: modulation by host of symbiont signal transduction mediated by G-protein beta subunit
namespace: biological_process
def: "Any process in which the host organism modulates the frequency, rate or extent of the symbiont signal transduction mediated by G-protein beta subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "modulation by symbiont of host signal transduction mediated by G-protein beta subunit ; GO:0075124".
is_a: GO:0075087 ! modulation by host of symbiont G-protein coupled receptor protein signal transduction

[Term]
id: GO:0075094
name: positive regulation by host of symbiont signal transduction mediated by G-protein beta subunit
namespace: biological_process
def: "Any process in which the host organism activates, maintains or increases the frequency, rate or extent of the symbiont signal transduction mediated by G-protein beta subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "positive regulation by symbiont of host signal transduction mediated by G-protein beta subunit ; GO:0075125".
is_a: GO:0075088 ! positive regulation by host of symbiont G-protein coupled receptor protein signal transduction
is_a: GO:0075093 ! modulation by host of symbiont signal transduction mediated by G-protein beta subunit

[Term]
id: GO:0075095
name: negative regulation by host of symbiont signal transduction mediated by G-protein beta subunit
namespace: biological_process
def: "Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of the symbiont signal transduction mediated by G-protein beta subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "negative regulation by symbiont of host signal transduction mediated by G-protein beta subunit ; GO:0075126".
is_a: GO:0075089 ! negative regulation by host of symbiont G-protein coupled receptor protein signal transduction
is_a: GO:0075093 ! modulation by host of symbiont signal transduction mediated by G-protein beta subunit

[Term]
id: GO:0075096
name: modulation by host of symbiont signal transduction mediated by G-protein gamma subunit
namespace: biological_process
def: "Any process in which the host organism modulates the frequency, rate or extent of the symbiont signal transduction mediated by G-protein gamma subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "modulation by symbiont of host signal transduction mediated by G-protein gamma subunit ; GO:0075127".
is_a: GO:0075087 ! modulation by host of symbiont G-protein coupled receptor protein signal transduction

[Term]
id: GO:0075097
name: positive regulation by host of symbiont signal transduction mediated by G-protein gamma subunit
namespace: biological_process
def: "Any process in which the host organism activates, maintains or increases the frequency, rate or extent of the symbiont signal transduction mediated by G-protein gamma subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "positive regulation by symbiont of host signal transduction mediated by G-protein gamma subunit ; GO:0075128".
is_a: GO:0075088 ! positive regulation by host of symbiont G-protein coupled receptor protein signal transduction
is_a: GO:0075096 ! modulation by host of symbiont signal transduction mediated by G-protein gamma subunit

[Term]
id: GO:0075098
name: negative regulation by host of symbiont signal transduction mediated by G-protein gamma subunit
namespace: biological_process
def: "Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of the symbiont signal transduction mediated by G-protein gamma subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "negative regulation by symbiont of host signal transduction mediated by G-protein gamma subunit ; GO:0075129".
is_a: GO:0075089 ! negative regulation by host of symbiont G-protein coupled receptor protein signal transduction
is_a: GO:0075096 ! modulation by host of symbiont signal transduction mediated by G-protein gamma subunit

[Term]
id: GO:0075099
name: modulation by host of symbiont protein kinase-mediated signal transduction
namespace: biological_process
def: "Any process in which the host organism modulates the frequency, rate or extent of protein kinase-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "modulation by symbiont of host protein kinase-mediated signal transduction ; GO:0075130".
is_a: GO:0052470 ! modulation by host of symbiont signal transduction pathway

[Term]
id: GO:0075100
name: positive regulation by host of symbiont protein kinase-mediated signal transduction
namespace: biological_process
def: "Any process in which the host organism activates, maintains or increases the frequency, rate or extent of protein kinase-mediated signal transduction in the symbiont organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "positive regulation by symbiont of host protein kinase-mediated signal transduction ; GO:0075131".
is_a: GO:0075099 ! modulation by host of symbiont protein kinase-mediated signal transduction

[Term]
id: GO:0075101
name: negative regulation by host of symbiont protein kinase-mediated signal transduction
namespace: biological_process
def: "Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of protein kinase-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "negative regulation by symbiont of host protein kinase-mediated signal transduction ; GO:0075132".
is_a: GO:0075099 ! modulation by host of symbiont protein kinase-mediated signal transduction

[Term]
id: GO:0075102
name: negative regulation by host of symbiont MAP kinase-mediated signal transduction
namespace: biological_process
def: "Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of the symbiont MAP kinase-mediated signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "negative regulation by symbiont of host MAP kinase-mediated signal transduction pathway ; GO:0052078".
is_a: GO:0052435 ! modulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway
is_a: GO:0075101 ! negative regulation by host of symbiont protein kinase-mediated signal transduction

[Term]
id: GO:0075103
name: modulation by host of symbiont calcium or calmodulin-mediated signal transduction
namespace: biological_process
def: "Any process in which the host organism modulates the frequency, rate or extent of calcium or calmodulin-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "modulation by symbiont of host calcium or calmodulin-mediated signal transduction ; GO:0075133".
synonym: "modulation by host of symbiont Ca++ or calmodulin-mediated signal transduction" EXACT []
is_a: GO:0052470 ! modulation by host of symbiont signal transduction pathway

[Term]
id: GO:0075104
name: positive regulation by host of symbiont calcium or calmodulin-mediated signal transduction
namespace: biological_process
def: "Any process in which the host organism activates, maintains or increases the frequency, rate or extent of calcium or calmodulin-mediated signal transduction in the symbiont organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "positive regulation by symbiont of host calcium or calmodulin-mediated signal transduction ; GO:0075134".
synonym: "positive regulation by host of symbiont Ca++ or calmodulin-mediated signal transduction" EXACT []
is_a: GO:0052525 ! positive regulation by host of symbiont signal transduction pathway
is_a: GO:0075103 ! modulation by host of symbiont calcium or calmodulin-mediated signal transduction

[Term]
id: GO:0075105
name: negative regulation by host of symbiont calcium or calmodulin-mediated signal transduction
namespace: biological_process
def: "Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of calcium or calmodulin-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "negative regulation by symbiont of host calcium or calmodulin-mediated signal transduction ; GO:0075135".
synonym: "negative regulation by host of symbiont Ca++ or calmodulin-mediated signal transduction" EXACT []
is_a: GO:0052492 ! negative regulation by host of symbiont signal transduction pathway
is_a: GO:0075103 ! modulation by host of symbiont calcium or calmodulin-mediated signal transduction

[Term]
id: GO:0075106
name: modulation by symbiont of host adenylate cyclase activity
namespace: biological_process
def: "Any process in which the symbiont modulates the frequency, rate or extent of the host adenylate cyclase activity, which involves catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont adenylate cyclase activity ; GO:0075075".
synonym: "Modulation by symbiont of host 3',5'-cyclic AMP synthetase activity" EXACT []
synonym: "Modulation by symbiont of host adenyl cyclase activity" EXACT []
synonym: "Modulation by symbiont of host adenylyl cyclase activity" EXACT []
synonym: "Modulation by symbiont of host adenylylcyclase activity" EXACT []
synonym: "Modulation by symbiont of host ATP diphosphate-lyase (cyclizing ; 3',5'-cyclic-AMP-forming) activity" EXACT []
synonym: "Modulation by symbiont of host ATP diphosphate-lyase (cyclizing) activity" EXACT []
synonym: "Modulation by symbiont of host ATP pyrophosphate-lyase activity" EXACT []
synonym: "Modulation by symbiont of host cAMP generating peptide activity" RELATED []
is_a: GO:0045761 ! regulation of adenylate cyclase activity
is_a: GO:0052148 ! modulation by symbiont of host catalytic activity

[Term]
id: GO:0075107
name: positive regulation by symbiont of host adenylate cyclase activity
namespace: biological_process
def: "Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of the host adenylate cyclase activity, which involves catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont adenylate cyclase activity ; GO:0075076".
synonym: "Positive regulation by symbiont of host 3',5'-cyclic AMP synthetase activity" EXACT []
synonym: "Positive regulation by symbiont of host adenyl cyclase activity" EXACT []
synonym: "Positive regulation by symbiont of host adenylyl cyclase activity" EXACT []
synonym: "Positive regulation by symbiont of host adenylylcyclase activity" EXACT []
synonym: "Positive regulation by symbiont of host ATP diphosphate-lyase (cyclizing ; 3',5'-cyclic-AMP-forming) activity" EXACT []
synonym: "Positive regulation by symbiont of host ATP diphosphate-lyase (cyclizing) activity" EXACT []
synonym: "Positive regulation by symbiont of host ATP pyrophosphate-lyase activity" EXACT []
synonym: "Positive regulation by symbiont of host cAMP generating peptide activity" RELATED []
is_a: GO:0043948 ! positive regulation by symbiont of host catalytic activity
is_a: GO:0045762 ! positive regulation of adenylate cyclase activity
is_a: GO:0075106 ! modulation by symbiont of host adenylate cyclase activity

[Term]
id: GO:0075108
name: negative regulation by symbiont of host adenylate cyclase activity
namespace: biological_process
def: "Any process in which the symbiont stops, prevents, or reduces the frequency, rate or extent of the host adenylate cyclase activity, which catalyze the reaction: ATP = 3',5'-cyclic AMP + diphosphate. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "negative regulation by host of symbiont adenylate cyclase activity ; GO:0075077".
synonym: "Negative regulation by symbiont of host 3',5'-cyclic AMP synthetase activity" EXACT []
synonym: "Negative regulation by symbiont of host adenyl cyclase activity" EXACT []
synonym: "Negative regulation by symbiont of host adenylyl cyclase activity" EXACT []
synonym: "Negative regulation by symbiont of host adenylylcyclase activity" EXACT []
synonym: "Negative regulation by symbiont of host ATP diphosphate-lyase (cyclizing ; 3',5'-cyclic-AMP-forming) activity" EXACT []
synonym: "Negative regulation by symbiont of host ATP diphosphate-lyase (cyclizing) activity" EXACT []
synonym: "Negative regulation by symbiont of host ATP pyrophosphate-lyase activity" EXACT []
synonym: "Negative regulation by symbiont of host cAMP generating peptide activity" RELATED []
is_a: GO:0007194 ! negative regulation of adenylate cyclase activity
is_a: GO:0052053 ! negative regulation by symbiont of host catalytic activity
is_a: GO:0075106 ! modulation by symbiont of host adenylate cyclase activity

[Term]
id: GO:0075109
name: modulation by symbiont of host receptor-mediated signal transduction
namespace: biological_process
def: "Any process in which the symbiont modulates the frequency, rate or extent of receptor-mediated signal transduction in the host organism. The receptor is defined as a protein on the cell membrane or within the cytoplasm or cell nucleus that binds to a specific molecule (a ligand) such as a neurotransmitter or a hormone or other substance, and initiates the cellular response to the ligand. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont receptor-mediated signal transduction ; GO:0075078".
is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway

[Term]
id: GO:0075110
name: positive regulation by symbiont of host receptor-mediated signal transduction
namespace: biological_process
def: "Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont receptor-mediated signal transduction ; GO:0075079".
is_a: GO:0052028 ! positive regulation by symbiont of host signal transduction pathway
is_a: GO:0075109 ! modulation by symbiont of host receptor-mediated signal transduction

[Term]
id: GO:0075111
name: negative regulation by symbiont of host receptor-mediated signal transduction
namespace: biological_process
def: "Any process in which the symbiont stops, prevents, or reduces the frequency, rate or extent of receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "negative regulation by host of symbiont receptor-mediated signal transduction ; GO:0075080".
is_a: GO:0052029 ! negative regulation by symbiont of host signal transduction pathway
is_a: GO:0075109 ! modulation by symbiont of host receptor-mediated signal transduction

[Term]
id: GO:0075112
name: modulation by symbiont of host transmembrane receptor-mediated signal transduction
namespace: biological_process
def: "Any process in which the symbiont modulates the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont transmembrane receptor-mediated signal transduction ; GO:0075081".
is_a: GO:0075109 ! modulation by symbiont of host receptor-mediated signal transduction

[Term]
id: GO:0075113
name: positive regulation by symbiont of host transmembrane receptor-mediated signal transduction
namespace: biological_process
def: "Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont transmembrane receptor-mediated signal transduction ; GO:0075082".
is_a: GO:0075110 ! positive regulation by symbiont of host receptor-mediated signal transduction
is_a: GO:0075112 ! modulation by symbiont of host transmembrane receptor-mediated signal transduction

[Term]
id: GO:0075114
name: negative regulation by symbiont of host transmembrane receptor-mediated signal transduction
namespace: biological_process
def: "Any process in which the symbiont stops, prevents, or reduces the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "negative regulation by host of symbiont transmembrane receptor-mediated signal transduction ; GO:0075083".
is_a: GO:0075111 ! negative regulation by symbiont of host receptor-mediated signal transduction
is_a: GO:0075112 ! modulation by symbiont of host transmembrane receptor-mediated signal transduction

[Term]
id: GO:0075115
name: modulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction
namespace: biological_process
def: "Any process in which the symbiont modulates the frequency, rate or extent of host transmembrane receptor-mediated cAMP signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction ; GO:0075084".
synonym: "modulation by symbiont of host transmembrane receptor-mediated cAMP signaling" EXACT []
is_a: GO:0075112 ! modulation by symbiont of host transmembrane receptor-mediated signal transduction
is_a: GO:0075208 ! modulation by symbiont of host cAMP-mediated signal transduction

[Term]
id: GO:0075116
name: positive regulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction
namespace: biological_process
def: "Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of host transmembrane receptor-mediated cAMP signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction ; GO:0075085".
synonym: "activation by symbiont of host transmembrane receptor-mediated cAMP signal transduction" NARROW []
synonym: "positive regulation by symbiont of host transmembrane receptor-mediated cAMP signaling" EXACT []
synonym: "promotion by symbiont of host transmembrane receptor-mediated cAMP signal transduction" EXACT []
synonym: "stimulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction" NARROW []
synonym: "upregulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction" EXACT []
is_a: GO:0075113 ! positive regulation by symbiont of host transmembrane receptor-mediated signal transduction
is_a: GO:0075115 ! modulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction
is_a: GO:0075209 ! positive regulation by symbiont of host cAMP-mediated signal transduction

[Term]
id: GO:0075117
name: negative regulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction
namespace: biological_process
def: "Any process in which the symbiont stops, prevents, or reduces the frequency, rate or extent of host transmembrane receptor-mediated cAMP signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "negative regulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction ; GO:0075086".
synonym: "downregulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction" EXACT []
synonym: "inhibition by symbiont of host transmembrane receptor-mediated cAMP signal transduction" NARROW []
synonym: "negative regulation by symbiont of host transmembrane receptor-mediated cAMP signaling" EXACT []
is_a: GO:0075114 ! negative regulation by symbiont of host transmembrane receptor-mediated signal transduction
is_a: GO:0075115 ! modulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction
is_a: GO:0075210 ! negative regulation by symbiont of host cAMP-mediated signal transduction

[Term]
id: GO:0075118
name: modulation by symbiont of host G-protein coupled receptor protein signal transduction
namespace: biological_process
def: "Any process in which the symbiont modulates the frequency, rate or extent of the host G-protein coupled receptor protein signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont G-protein coupled receptor protein signal transduction ; GO:0075087".
is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:0075112 ! modulation by symbiont of host transmembrane receptor-mediated signal transduction

[Term]
id: GO:0075119
name: positive regulation by symbiont of host G-protein coupled receptor protein signal transduction
namespace: biological_process
def: "Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of the host G-protein coupled receptor protein signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by symbiont of host G-protein coupled receptor protein signal transduction ; GO:0075088".
is_a: GO:0045745 ! positive regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:0075113 ! positive regulation by symbiont of host transmembrane receptor-mediated signal transduction
is_a: GO:0075118 ! modulation by symbiont of host G-protein coupled receptor protein signal transduction

[Term]
id: GO:0075120
name: negative regulation by symbiont of host G-protein coupled receptor protein signal transduction
namespace: biological_process
def: "Any process in which the symbiont stops, prevents, or reduces the frequency, rate or extent of the host G-protein coupled receptor protein signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "negative regulation by host of symbiont G-protein coupled receptor protein signal transduction ; GO:0075089".
is_a: GO:0045744 ! negative regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:0075114 ! negative regulation by symbiont of host transmembrane receptor-mediated signal transduction
is_a: GO:0075118 ! modulation by symbiont of host G-protein coupled receptor protein signal transduction

[Term]
id: GO:0075121
name: modulation by symbiont of host signal transduction mediated by G-protein alpha subunit
namespace: biological_process
def: "Any process in which the symbiont modulates the frequency, rate or extent of the host signal transduction mediated by G-protein alpha subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont signal transduction mediated by G-protein alpha subunit ; GO:0075090".
is_a: GO:0075118 ! modulation by symbiont of host G-protein coupled receptor protein signal transduction

[Term]
id: GO:0075122
name: positive regulation by symbiont of host signal transduction mediated by G-protein alpha subunit
namespace: biological_process
def: "Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of the host signal transduction mediated by G-protein alpha subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont signal transduction mediated by G-protein alpha subunit ; GO:0075091".
is_a: GO:0075119 ! positive regulation by symbiont of host G-protein coupled receptor protein signal transduction
is_a: GO:0075121 ! modulation by symbiont of host signal transduction mediated by G-protein alpha subunit

[Term]
id: GO:0075123
name: negative regulation by symbiont of host signal transduction mediated by G-protein alpha subunit
namespace: biological_process
def: "Any process in which the symbiont stops, prevents, or reduces the frequency, rate or extent of the host signal transduction mediated by G-protein alpha subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "negative regulation by host of symbiont signal transduction mediated by G-protein alpha subunit ; GO:0075092".
is_a: GO:0075120 ! negative regulation by symbiont of host G-protein coupled receptor protein signal transduction
is_a: GO:0075121 ! modulation by symbiont of host signal transduction mediated by G-protein alpha subunit

[Term]
id: GO:0075124
name: modulation by symbiont of host signal transduction mediated by G-protein beta subunit
namespace: biological_process
def: "Any process in which the symbiont modulates the frequency, rate or extent of the host signal transduction mediated by G-protein beta subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont signal transduction mediated by G-protein beta subunit ; GO:0075093".
is_a: GO:0075118 ! modulation by symbiont of host G-protein coupled receptor protein signal transduction

[Term]
id: GO:0075125
name: positive regulation by symbiont of host signal transduction mediated by G-protein beta subunit
namespace: biological_process
def: "Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of the host signal transduction mediated by G-protein beta subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont signal transduction mediated by G-protein beta subunit ; GO:0075094".
is_a: GO:0075119 ! positive regulation by symbiont of host G-protein coupled receptor protein signal transduction
is_a: GO:0075124 ! modulation by symbiont of host signal transduction mediated by G-protein beta subunit

[Term]
id: GO:0075126
name: negative regulation by symbiont of host signal transduction mediated by G-protein beta subunit
namespace: biological_process
def: "Any process in which the symbiont stops, prevents, or reduces the frequency, rate or extent of the host signal transduction mediated by G-protein beta subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "negative regulation by host of symbiont signal transduction mediated by G-protein beta subunit ; GO:0075095".
is_a: GO:0075120 ! negative regulation by symbiont of host G-protein coupled receptor protein signal transduction
is_a: GO:0075124 ! modulation by symbiont of host signal transduction mediated by G-protein beta subunit

[Term]
id: GO:0075127
name: modulation by symbiont of host signal transduction mediated by G-protein gamma subunit
namespace: biological_process
def: "Any process in which the symbiont modulates the frequency, rate or extent of the host signal transduction mediated by G-protein gamma subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont signal transduction mediated by G-protein gamma subunit ; GO:0075096".
is_a: GO:0075118 ! modulation by symbiont of host G-protein coupled receptor protein signal transduction

[Term]
id: GO:0075128
name: positive regulation by symbiont of host signal transduction mediated by G-protein gamma subunit
namespace: biological_process
def: "Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of the host signal transduction mediated by G-protein gamma subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont signal transduction mediated by G-protein gamma subunit ; GO:0075097".
is_a: GO:0075119 ! positive regulation by symbiont of host G-protein coupled receptor protein signal transduction
is_a: GO:0075127 ! modulation by symbiont of host signal transduction mediated by G-protein gamma subunit

[Term]
id: GO:0075129
name: negative regulation by symbiont of host signal transduction mediated by G-protein gamma subunit
namespace: biological_process
def: "Any process in which the symbiont stops, prevents, or reduces the frequency, rate or extent of the host signal transduction mediated by G-protein gamma subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "negative regulation by host of symbiont signal transduction mediated by G-protein gamma subunit ; GO:0075098".
is_a: GO:0075120 ! negative regulation by symbiont of host G-protein coupled receptor protein signal transduction
is_a: GO:0075127 ! modulation by symbiont of host signal transduction mediated by G-protein gamma subunit

[Term]
id: GO:0075130
name: modulation by symbiont of host protein kinase-mediated signal transduction
namespace: biological_process
def: "Any process in which the symbiont modulates the frequency, rate or extent of protein kinase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont protein kinase-mediated signal transduction ; GO:0075099".
is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway

[Term]
id: GO:0075131
name: positive regulation by symbiont of host protein kinase-mediated signal transduction
namespace: biological_process
def: "Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of protein kinase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont protein kinase-mediated signal transduction ; GO:0075100".
is_a: GO:0052028 ! positive regulation by symbiont of host signal transduction pathway
is_a: GO:0075130 ! modulation by symbiont of host protein kinase-mediated signal transduction

[Term]
id: GO:0075132
name: negative regulation by symbiont of host protein kinase-mediated signal transduction
namespace: biological_process
def: "Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of protein kinase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "negative regulation by host of symbiont protein kinase-mediated signal transduction ; GO:0075101".
is_a: GO:0052029 ! negative regulation by symbiont of host signal transduction pathway
is_a: GO:0075130 ! modulation by symbiont of host protein kinase-mediated signal transduction

[Term]
id: GO:0075133
name: modulation by symbiont of host calcium or calmodulin-mediated signal transduction
namespace: biological_process
def: "Any process in which the symbiont modulates the frequency, rate or extent of calcium or calmodulin-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont calcium or calmodulin-mediated signal transduction ; GO:0075103".
synonym: "modulation by symbiont of host Ca++ or calmodulin-mediated signal transduction" EXACT []
is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway

[Term]
id: GO:0075134
name: positive regulation by symbiont of host calcium or calmodulin-mediated signal transduction
namespace: biological_process
def: "Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of calcium or calmodulin-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont calcium or calmodulin-mediated signal transduction ; GO:0075104".
synonym: "positive regulation by symbiont of host Ca++ or calmodulin-mediated signal transduction" EXACT []
is_a: GO:0052028 ! positive regulation by symbiont of host signal transduction pathway
is_a: GO:0075133 ! modulation by symbiont of host calcium or calmodulin-mediated signal transduction

[Term]
id: GO:0075135
name: negative regulation by symbiont of host calcium or calmodulin-mediated signal transduction
namespace: biological_process
def: "Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of calcium or calmodulin-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "Negative regulation by host of symbiont calcium or calmodulin-mediated signal transduction ; GO:0075105".
synonym: "negative regulation by symbiont of host Ca++ or calmodulin-mediated signal transduction" EXACT []
is_a: GO:0052029 ! negative regulation by symbiont of host signal transduction pathway
is_a: GO:0075133 ! modulation by symbiont of host calcium or calmodulin-mediated signal transduction

[Term]
id: GO:0075136
name: response to host
namespace: biological_process
def: "Any process that results in a change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
subset: gosubset_prok
synonym: "response of symbiont to host" RELATED []
is_a: GO:0051701 ! interaction with host
is_a: GO:0051707 ! response to other organism

[Term]
id: GO:0075137
name: response to host redox environment
namespace: biological_process
def: "Any process that results in a change in state or activity of the symbiont organism or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the redox environment in host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "response of symbiont to host redox environment" EXACT []
is_a: GO:0075136 ! response to host

[Term]
id: GO:0075138
name: response to host oxygen tension environment
namespace: biological_process
def: "Any process that results in a change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting oxygen tension in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "response of symbiont to host oxygen tension environment" EXACT []
is_a: GO:0075136 ! response to host

[Term]
id: GO:0075139
name: response to host iron concentration
namespace: biological_process
def: "Any process that results in a change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting iron concentration in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "response of symbiont to host iron concentration" EXACT []
is_a: GO:0075136 ! response to host

[Term]
id: GO:0075140
name: response to host defense molecules
namespace: biological_process
def: "Any process that results in a change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting host defense molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "response of symbiont to host defense molecules" EXACT []
is_a: GO:0075136 ! response to host

[Term]
id: GO:0075141
name: maintenance of symbiont tolerance to host environment
namespace: biological_process
def: "Any process that contributes to the maintenance of a physiologic state in which the symbiont immune system does not react destructively against the components of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
is_a: GO:0075136 ! response to host

[Term]
id: GO:0075142
name: maintenance of symbiont tolerance to host oxygen tension environment
namespace: biological_process
def: "Any process that contributes to the maintenance of a physiologic state in which the symbiont immune system does not react destructively against oxygen tension environment of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
is_a: GO:0075138 ! response to host oxygen tension environment
is_a: GO:0075141 ! maintenance of symbiont tolerance to host environment

[Term]
id: GO:0075143
name: maintenance of symbiont tolerance to host redox environment
namespace: biological_process
def: "Any process that contributes to the maintenance of a physiologic state in which the symbiont immune system does not react destructively against redox environment of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
is_a: GO:0075137 ! response to host redox environment
is_a: GO:0075141 ! maintenance of symbiont tolerance to host environment

[Term]
id: GO:0075144
name: maintenance of symbiont tolerance to host iron concentration
namespace: biological_process
def: "Any process that contributes to the maintenance of a physiologic state in which the symbiont immune system does not react destructively against iron concentration environment of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
is_a: GO:0075139 ! response to host iron concentration
is_a: GO:0075141 ! maintenance of symbiont tolerance to host environment

[Term]
id: GO:0075145
name: maintenance of symbiont tolerance to host defense molecules
namespace: biological_process
def: "Any process that contributes to the maintenance of a physiologic state in which the symbiont immune system does not react destructively against defense molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
is_a: GO:0075140 ! response to host defense molecules
is_a: GO:0075141 ! maintenance of symbiont tolerance to host environment

[Term]
id: GO:0075146
name: maintenance of symbiont tolerance to host osmotic environment
namespace: biological_process
def: "Any process that contributes to the maintenance of a physiologic state in which the symbiont immune system does not react destructively against osmotic environment of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
is_a: GO:0075000 ! response to host osmotic environment
is_a: GO:0075141 ! maintenance of symbiont tolerance to host environment

[Term]
id: GO:0075147
name: regulation of signal transduction in response to host
namespace: biological_process
def: "Any process in which the symbiont organism modulates the frequency, rate or extent of its signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "regulation of symbiont signal transduction in response to host" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0075136 ! response to host

[Term]
id: GO:0075148
name: positive regulation of signal transduction in response to host
namespace: biological_process
def: "Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "positive regulation of symbiont signal transduction in response to host" EXACT []
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0075147 ! regulation of signal transduction in response to host

[Term]
id: GO:0075149
name: negative regulation of signal transduction in response to host
namespace: biological_process
def: "Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "negative regulation of symbiont signal transduction in response to host" EXACT []
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0075147 ! regulation of signal transduction in response to host

[Term]
id: GO:0075150
name: regulation of receptor-mediated signal transduction in response to host
namespace: biological_process
def: "Any process in which the symbiont organism modulates the frequency, rate or extent of its receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "regulation of symbiont receptor-mediated signal transduction in response to host" EXACT []
is_a: GO:0075147 ! regulation of signal transduction in response to host

[Term]
id: GO:0075151
name: positive regulation of receptor-mediated signal transduction in response to host
namespace: biological_process
def: "Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "positive regulation of symbiont receptor-mediated signal transduction in response to host" EXACT []
is_a: GO:0075148 ! positive regulation of signal transduction in response to host
is_a: GO:0075150 ! regulation of receptor-mediated signal transduction in response to host

[Term]
id: GO:0075152
name: negative regulation of receptor-mediated signal transduction in response to host
namespace: biological_process
def: "Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "negative regulation of symbiont receptor-mediated signal transduction in response to host" EXACT []
is_a: GO:0075149 ! negative regulation of signal transduction in response to host
is_a: GO:0075150 ! regulation of receptor-mediated signal transduction in response to host

[Term]
id: GO:0075153
name: regulation of transmembrane receptor-mediated signal transduction in response to host
namespace: biological_process
def: "Any process in which the symbiont organism modulates the frequency, rate or extent of its transmembrane receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "regulation of symbiont transmembrane receptor-mediated signal transduction in response to host" EXACT []
is_a: GO:0075150 ! regulation of receptor-mediated signal transduction in response to host

[Term]
id: GO:0075154
name: positive regulation of transmembrane receptor-mediated signal transduction in response to host
namespace: biological_process
def: "Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its transmembrane receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "positive regulation of symbiont transmembrane receptor-mediated signal transduction in response to host" EXACT []
is_a: GO:0075151 ! positive regulation of receptor-mediated signal transduction in response to host
is_a: GO:0075153 ! regulation of transmembrane receptor-mediated signal transduction in response to host

[Term]
id: GO:0075155
name: negative regulation of transmembrane receptor-mediated signal transduction in response to host
namespace: biological_process
def: "Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont transmembrane receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "negative regulation of symbiont transmembrane receptor-mediated signal transduction in response to host" EXACT []
is_a: GO:0075152 ! negative regulation of receptor-mediated signal transduction in response to host
is_a: GO:0075153 ! regulation of transmembrane receptor-mediated signal transduction in response to host

[Term]
id: GO:0075156
name: regulation of G-protein coupled receptor protein signaling pathway in response to host
namespace: biological_process
def: "Any process in which the symbiont organism modulates the frequency, rate or extent of its G-protein coupled receptor protein-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "regulation of G-protein coupled receptor protein signalling pathway in response to host" EXACT [GOC:mah]
synonym: "regulation of symbiont G-protein coupled receptor protein-mediated signal transduction in response to host" EXACT []
is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:0075153 ! regulation of transmembrane receptor-mediated signal transduction in response to host

[Term]
id: GO:0075157
name: positive regulation of G-protein coupled receptor protein signaling pathway in response to host
namespace: biological_process
def: "Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its G-protein coupled receptor protein-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "positive regulation of G-protein coupled receptor protein signalling pathway in response to host" EXACT [GOC:mah]
synonym: "positive regulation of symbiont G-protein coupled receptor protein-mediated signal transduction in response to host" EXACT []
is_a: GO:0045745 ! positive regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:0075154 ! positive regulation of transmembrane receptor-mediated signal transduction in response to host
is_a: GO:0075156 ! regulation of G-protein coupled receptor protein signaling pathway in response to host

[Term]
id: GO:0075158
name: negative regulation of G-protein coupled receptor protein signaling pathway in response to host
namespace: biological_process
def: "Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont G-protein coupled receptor protein-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "negative regulation of G-protein coupled receptor protein signalling pathway in response to host" EXACT [GOC:mah]
synonym: "negative regulation of symbiont G-protein coupled receptor protein-mediated signal transduction in response to host" EXACT []
is_a: GO:0045744 ! negative regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:0075155 ! negative regulation of transmembrane receptor-mediated signal transduction in response to host
is_a: GO:0075156 ! regulation of G-protein coupled receptor protein signaling pathway in response to host

[Term]
id: GO:0075159
name: regulation of G-protein alpha subunit-mediated signal transduction in response to host
namespace: biological_process
def: "Any process in which the symbiont organism modulates the frequency, rate or extent of its G-protein alpha subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "regulation of symbiont G-protein alpha subunit-mediated signal transduction in response to host" EXACT []
is_a: GO:0075156 ! regulation of G-protein coupled receptor protein signaling pathway in response to host

[Term]
id: GO:0075160
name: positive regulation of G-protein alpha subunit-mediated signal transduction in response to host
namespace: biological_process
def: "Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its G-protein alpha subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "positive regulation of symbiont G-protein alpha subunit-mediated signal transduction in response to host" EXACT []
is_a: GO:0075157 ! positive regulation of G-protein coupled receptor protein signaling pathway in response to host
is_a: GO:0075159 ! regulation of G-protein alpha subunit-mediated signal transduction in response to host

[Term]
id: GO:0075161
name: negative regulation of G-protein alpha subunit-mediated signal transduction in response to host
namespace: biological_process
def: "Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont G-protein alpha subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "negative regulation of symbiont G-protein alpha subunit-mediated signal transduction in response to host" EXACT []
is_a: GO:0075158 ! negative regulation of G-protein coupled receptor protein signaling pathway in response to host
is_a: GO:0075159 ! regulation of G-protein alpha subunit-mediated signal transduction in response to host

[Term]
id: GO:0075162
name: regulation of G-protein beta subunit-mediated signal transduction in response to host
namespace: biological_process
def: "Any process in which the symbiont organism modulates the frequency, rate or extent of its G-protein beta subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "regulation of symbiont G-protein beta subunit-mediated signal transduction in response to host" EXACT []
is_a: GO:0075156 ! regulation of G-protein coupled receptor protein signaling pathway in response to host

[Term]
id: GO:0075163
name: positive regulation of G-protein beta subunit-mediated signal transduction in response to host
namespace: biological_process
def: "Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its G-protein beta subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "positive regulation of symbiont G-protein beta subunit-mediated signal transduction in response to host" EXACT []
is_a: GO:0075157 ! positive regulation of G-protein coupled receptor protein signaling pathway in response to host
is_a: GO:0075162 ! regulation of G-protein beta subunit-mediated signal transduction in response to host

[Term]
id: GO:0075164
name: negative regulation of G-protein beta subunit-mediated signal transduction in response to host
namespace: biological_process
def: "Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont G-protein beta subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "negative regulation of symbiont G-protein beta subunit-mediated signal transduction in response to host" EXACT []
is_a: GO:0075158 ! negative regulation of G-protein coupled receptor protein signaling pathway in response to host
is_a: GO:0075162 ! regulation of G-protein beta subunit-mediated signal transduction in response to host

[Term]
id: GO:0075165
name: regulation of G-protein gamma subunit-mediated signal transduction in response to host
namespace: biological_process
def: "Any process in which the symbiont organism modulates the frequency, rate or extent of its G-protein gamma subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "regulation of symbiont G-protein gamma subunit-mediated signal transduction in response to host" EXACT []
is_a: GO:0075156 ! regulation of G-protein coupled receptor protein signaling pathway in response to host

[Term]
id: GO:0075166
name: positive regulation of G-protein gamma subunit-mediated signal transduction in response to host
namespace: biological_process
def: "Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its G-protein gamma subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "positive regulation of symbiont G-protein gamma subunit-mediated signal transduction in response to host" EXACT []
is_a: GO:0075157 ! positive regulation of G-protein coupled receptor protein signaling pathway in response to host
is_a: GO:0075165 ! regulation of G-protein gamma subunit-mediated signal transduction in response to host

[Term]
id: GO:0075167
name: negative regulation of G-protein gamma subunit-mediated signal transduction in response to host
namespace: biological_process
def: "Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont G-protein gamma subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "negative regulation of symbiont G-protein gamma subunit-mediated signal transduction in response to host" EXACT []
is_a: GO:0075158 ! negative regulation of G-protein coupled receptor protein signaling pathway in response to host
is_a: GO:0075165 ! regulation of G-protein gamma subunit-mediated signal transduction in response to host

[Term]
id: GO:0075168
name: regulation of protein kinase-mediated signal transduction in response to host
namespace: biological_process
def: "Any process in which the symbiont organism modulates the frequency, rate or extent of its protein kinase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "regulation of symbiont protein kinase-mediated signal transduction in response to host" EXACT []
is_a: GO:0075147 ! regulation of signal transduction in response to host

[Term]
id: GO:0075169
name: positive regulation of symbiont protein kinase-mediated signal transduction in response to host
namespace: biological_process
def: "Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its protein kinase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
is_a: GO:0075148 ! positive regulation of signal transduction in response to host
is_a: GO:0075168 ! regulation of protein kinase-mediated signal transduction in response to host

[Term]
id: GO:0075170
name: negative regulation of protein kinase-mediated signal transduction in response to host
namespace: biological_process
def: "Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont protein kinase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "negative regulation of symbiont protein kinase-mediated signal transduction in response to host" EXACT []
is_a: GO:0075149 ! negative regulation of signal transduction in response to host
is_a: GO:0075168 ! regulation of protein kinase-mediated signal transduction in response to host

[Term]
id: GO:0075171
name: regulation of MAP kinase-mediated signal transduction in response to host
namespace: biological_process
def: "Any process in which the symbiont organism modulates the frequency, rate or extent of its MAP kinase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "regulation of symbiont MAP kinase-mediated signal transduction in response to host" EXACT []
is_a: GO:0075168 ! regulation of protein kinase-mediated signal transduction in response to host

[Term]
id: GO:0075172
name: positive regulation of MAP kinase-mediated signal transduction in response to host
namespace: biological_process
def: "Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its MAP kinase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "positive regulation of symbiont MAP kinase-mediated signal transduction in response to host" EXACT []
is_a: GO:0075169 ! positive regulation of symbiont protein kinase-mediated signal transduction in response to host
is_a: GO:0075171 ! regulation of MAP kinase-mediated signal transduction in response to host

[Term]
id: GO:0075173
name: negative regulation of MAP kinase-mediated signal transduction in response to host
namespace: biological_process
def: "Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont MAP kinase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "negative regulation of symbiont MAP kinase-mediated signal transduction in response to host" EXACT []
is_a: GO:0075170 ! negative regulation of protein kinase-mediated signal transduction in response to host
is_a: GO:0075171 ! regulation of MAP kinase-mediated signal transduction in response to host

[Term]
id: GO:0075174
name: regulation of cAMP-mediated signaling in response to host
namespace: biological_process
def: "Any process in which the symbiont organism modulates the frequency, rate or extent of its cAMP-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "regulation of cAMP-mediated signal transduction in response to host" EXACT []
synonym: "regulation of cAMP-mediated signalling in response to host" EXACT []
synonym: "regulation of symbiont cAMP-mediated signal transduction in response to host" EXACT []
is_a: GO:0043949 ! regulation of cAMP-mediated signaling
is_a: GO:0075147 ! regulation of signal transduction in response to host

[Term]
id: GO:0075175
name: positive regulation of cAMP-mediated signaling in response to host
namespace: biological_process
def: "Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its cAMP-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "positive regulation of cAMP-mediated signal transduction in response to host" EXACT []
synonym: "positive regulation of cAMP-mediated signalling in response to host" EXACT []
synonym: "positive regulation of symbiont cAMP-mediated signal transduction in response to host" EXACT []
is_a: GO:0075148 ! positive regulation of signal transduction in response to host
is_a: GO:0075174 ! regulation of cAMP-mediated signaling in response to host

[Term]
id: GO:0075176
name: negative regulation of cAMP-mediated signaling in response to host
namespace: biological_process
def: "Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its cAMP-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "negative regulation of cAMP-mediated signal transduction in response to host" EXACT []
synonym: "negative regulation of cAMP-mediated signalling in response to host" EXACT []
synonym: "negative regulation of symbiont cAMP-mediated signal transduction in response to host" EXACT []
is_a: GO:0043951 ! negative regulation of cAMP-mediated signaling
is_a: GO:0075149 ! negative regulation of signal transduction in response to host
is_a: GO:0075174 ! regulation of cAMP-mediated signaling in response to host

[Term]
id: GO:0075177
name: regulation of calcium or calmodulin-mediated signal transduction in response to host
namespace: biological_process
def: "Any process in which the symbiont organism modulates the frequency, rate or extent of its calcium or calmodulin-mediated signal transduction as a result of detecting host molecules in, on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "modulation of symbiont Ca++ or calmodulin-mediated signal transduction in response to host" EXACT []
synonym: "modulation of symbiont calcium or calmodulin-mediated signal transduction in response to host" EXACT []
is_a: GO:0075147 ! regulation of signal transduction in response to host

[Term]
id: GO:0075178
name: positive regulation of calcium or calmodulin-mediated signal transduction in response to host
namespace: biological_process
def: "Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its calcium or calmodulin-mediated signal transduction as a result of detecting host molecules in, on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "positive regulation of symbiont Ca++ or calmodulin-mediated signal transduction in response to host" EXACT []
synonym: "positive regulation of symbiont calcium or calmodulin-mediated signal transduction in response to host" EXACT []
is_a: GO:0075148 ! positive regulation of signal transduction in response to host
is_a: GO:0075177 ! regulation of calcium or calmodulin-mediated signal transduction in response to host

[Term]
id: GO:0075179
name: negative regulation of calcium or calmodulin-mediated signal transduction in response to host
namespace: biological_process
def: "Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont calcium or calmodulin-mediated signal transduction as a result of detecting host molecules in, on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "negative regulation of symbiont Ca++ or calmodulin-mediated signal transduction in response to host" EXACT []
synonym: "negative regulation of symbiont calcium or calmodulin-mediated signal transduction in response to host" EXACT []
is_a: GO:0075149 ! negative regulation of signal transduction in response to host
is_a: GO:0075177 ! regulation of calcium or calmodulin-mediated signal transduction in response to host

[Term]
id: GO:0075180
name: regulation of transcription in response to host
namespace: biological_process
def: "Any process in which the symbiont organism modulates the frequency, rate or extent of its transcription as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "regulation of symbiont transcription in response to host" EXACT []
is_a: GO:0075136 ! response to host
is_a: GO:2001141 ! regulation of RNA biosynthetic process

[Term]
id: GO:0075181
name: positive regulation of symbiont transcription in response to host
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of its transcription as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process
is_a: GO:0075180 ! regulation of transcription in response to host

[Term]
id: GO:0075182
name: negative regulation of symbiont transcription in response to host
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of its transcription as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process
is_a: GO:0075180 ! regulation of transcription in response to host

[Term]
id: GO:0075183
name: infection cushion formation on or near host
namespace: biological_process
def: "The process in which an organized mass of hyphae is formed on or near the host organism, and numerous infective hyphae develop from the hyphae mass. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0075015 ! formation of infection structure on or near host

[Term]
id: GO:0075184
name: regulation of infection cushion formation on or near host
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of symbiont infection cushion formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0075183 ! infection cushion formation on or near host
relationship: regulates GO:0075183 ! infection cushion formation on or near host

[Term]
id: GO:0075185
name: positive regulation of infection cushion formation on or near host
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of symbiont infection cushion formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0044149 ! positive regulation of development of symbiont involved in interaction with host
is_a: GO:0075184 ! regulation of infection cushion formation on or near host
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0075183 ! infection cushion formation on or near host
relationship: positively_regulates GO:0075183 ! infection cushion formation on or near host

[Term]
id: GO:0075186
name: negative regulation of infection cushion formation on or near host
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont infection cushion formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0044147 ! negative regulation of development of symbiont involved in interaction with host
is_a: GO:0075184 ! regulation of infection cushion formation on or near host
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0075183 ! infection cushion formation on or near host
relationship: negatively_regulates GO:0075183 ! infection cushion formation on or near host

[Term]
id: GO:0075187
name: hyphopodium formation on or near host
namespace: biological_process
def: "The process in which a specialized structure, consisted of stalked, thick-walled, lobed cells of vegetative epiphytic hyphae, is formed, to attach and penetrate the host surface. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0075015 ! formation of infection structure on or near host

[Term]
id: GO:0075188
name: regulation of hyphopodium formation on or near host
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of symbiont hyphopodium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0044138 ! modulation of development of symbiont on or near host
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0075187 ! hyphopodium formation on or near host
relationship: regulates GO:0075187 ! hyphopodium formation on or near host

[Term]
id: GO:0075189
name: positive regulation of hyphopodium formation on or near host
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of symbiont hyphopodium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0044143 ! positive regulation of development of symbiont on or near host surface
is_a: GO:0075188 ! regulation of hyphopodium formation on or near host
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0075187 ! hyphopodium formation on or near host
relationship: positively_regulates GO:0075187 ! hyphopodium formation on or near host

[Term]
id: GO:0075190
name: negative regulation of hyphopodium formation on or near host
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont hyphopodium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0044141 ! negative regulation of development of symbiont on or near host surface
is_a: GO:0075188 ! regulation of hyphopodium formation on or near host
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0075187 ! hyphopodium formation on or near host
relationship: negatively_regulates GO:0075187 ! hyphopodium formation on or near host

[Term]
id: GO:0075191
name: autophagy of host cells on or near symbiont surface
namespace: biological_process
def: "The process in which the host cells digest parts of their own cytoplasm, occurring when the host is on or near its symbiont surface. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should be used to annotate gene products of host.
is_a: GO:0075044 ! autophagy of host cells involved in interaction with symbiont

[Term]
id: GO:0075192
name: haustorium mother cell formation on or near host
namespace: biological_process
def: "The process in which a symbiont cell is formed on or near its host organism, via separated from the tip of an infection hypha by a septum. The haustorium mother cell usually contains 2-4 fungal nuclei, and its function is to attach and penetrate the host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0075015 ! formation of infection structure on or near host

[Term]
id: GO:0075193
name: regulation of haustorium mother cell formation on or near host
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of symbiont haustorium mother cell formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0044138 ! modulation of development of symbiont on or near host
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0075192 ! haustorium mother cell formation on or near host
relationship: regulates GO:0075192 ! haustorium mother cell formation on or near host

[Term]
id: GO:0075194
name: positive regulation of haustorium mother cell formation on or near host
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of symbiont haustorium mother cell formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0044143 ! positive regulation of development of symbiont on or near host surface
is_a: GO:0075193 ! regulation of haustorium mother cell formation on or near host
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0075192 ! haustorium mother cell formation on or near host
relationship: positively_regulates GO:0075192 ! haustorium mother cell formation on or near host

[Term]
id: GO:0075195
name: negative regulation of haustorium mother cell formation on or near host
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont haustorium mother cell formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0044141 ! negative regulation of development of symbiont on or near host surface
is_a: GO:0075193 ! regulation of haustorium mother cell formation on or near host
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0075192 ! haustorium mother cell formation on or near host
relationship: negatively_regulates GO:0075192 ! haustorium mother cell formation on or near host

[Term]
id: GO:0075196
name: adhesion of symbiont haustorium mother cell to host
namespace: biological_process
def: "The attachment of a haustorium mother cell of the symbiont to its host via adhesion molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "adhesion of symbiont haustorium mother cell to host during symbiotic interaction" EXACT []
is_a: GO:0075001 ! adhesion of symbiont infection structure to host

[Term]
id: GO:0075197
name: formation of symbiont haustorium neck for entry into host
namespace: biological_process
def: "The assembly by the symbiont of a neck-like structure for the purpose of penetration into its host organism. The neck-like structure connects haustorium mother cell and haustorium. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "symbiont haustorium neck formation for entry into host" EXACT []
is_a: GO:0075015 ! formation of infection structure on or near host
relationship: part_of GO:0075052 ! entry into host via a specialized structure

[Term]
id: GO:0075198
name: modulation of symbiont haustorium neck formation for entry into host
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of symbiont haustorium neck formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0044145 ! modulation of development of symbiont involved in interaction with host
is_a: GO:0052372 ! modulation by symbiont of entry into host
relationship: regulates GO:0075197 ! formation of symbiont haustorium neck for entry into host

[Term]
id: GO:0075199
name: positive regulation of symbiont haustorium neck formation for entry into host
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of symbiont haustorium neck formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0040017 ! positive regulation of locomotion
is_a: GO:0044149 ! positive regulation of development of symbiont involved in interaction with host
is_a: GO:0075198 ! modulation of symbiont haustorium neck formation for entry into host
is_a: GO:0075294 ! positive regulation by symbiont of entry into host
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0075197 ! formation of symbiont haustorium neck for entry into host
relationship: positively_regulates GO:0075197 ! formation of symbiont haustorium neck for entry into host

[Term]
id: GO:0075200
name: negative regulation of symbiont haustorium neck formation for entry into host
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont haustorium neck formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0040013 ! negative regulation of locomotion
is_a: GO:0044147 ! negative regulation of development of symbiont involved in interaction with host
is_a: GO:0052374 ! negative regulation by symbiont of entry into host
is_a: GO:0075198 ! modulation of symbiont haustorium neck formation for entry into host
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0075197 ! formation of symbiont haustorium neck for entry into host
relationship: negatively_regulates GO:0075197 ! formation of symbiont haustorium neck for entry into host

[Term]
id: GO:0075201
name: formation of symbiont penetration hypha for entry into host
namespace: biological_process
def: "The assembly by the symbiont of a threadlike, tubular structure, which may contain multiple nuclei and may or may not be divided internally by septa or cross-walls, for the purpose of penetration into its host organism. In the case of an appressorium existing, this term is defined in further details as the process in which the symbiont penetration peg expands to form a hypha which traverses the epidermal cell and emerges into the intercellular space of the mesophyll tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "symbiont penetration hypha formation for entry into host" EXACT []
is_a: GO:0075015 ! formation of infection structure on or near host
relationship: part_of GO:0075052 ! entry into host via a specialized structure

[Term]
id: GO:0075202
name: modulation of symbiont penetration hypha formation for entry into host
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of symbiont penetration hypha formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0044145 ! modulation of development of symbiont involved in interaction with host
is_a: GO:0052372 ! modulation by symbiont of entry into host
relationship: regulates GO:0075201 ! formation of symbiont penetration hypha for entry into host

[Term]
id: GO:0075203
name: positive regulation of symbiont penetration hypha formation for entry into host
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of symbiont penetration hypha formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0040017 ! positive regulation of locomotion
is_a: GO:0044149 ! positive regulation of development of symbiont involved in interaction with host
is_a: GO:0075202 ! modulation of symbiont penetration hypha formation for entry into host
is_a: GO:0075294 ! positive regulation by symbiont of entry into host
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0075201 ! formation of symbiont penetration hypha for entry into host
relationship: positively_regulates GO:0075201 ! formation of symbiont penetration hypha for entry into host

[Term]
id: GO:0075204
name: negative regulation of symbiont penetration hypha formation for entry into host
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont penetration hypha formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0040013 ! negative regulation of locomotion
is_a: GO:0044147 ! negative regulation of development of symbiont involved in interaction with host
is_a: GO:0052374 ! negative regulation by symbiont of entry into host
is_a: GO:0075202 ! modulation of symbiont penetration hypha formation for entry into host
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0075201 ! formation of symbiont penetration hypha for entry into host
relationship: negatively_regulates GO:0075201 ! formation of symbiont penetration hypha for entry into host

[Term]
id: GO:0075205
name: modulation by host of symbiont cAMP-mediated signal transduction
namespace: biological_process
def: "Any process in which the host organism modulates the frequency, rate or extent of cAMP-mediated signal transduction in the symbiont. The cAMP-mediated signal transduction is defined as a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "modulation by symbiont of host cAMP-mediated signal transduction ; GO:0075208".
synonym: "modulation by host of symbiont cAMP-mediated signaling" RELATED []
synonym: "modulation by host of symbiont cAMP-mediated signalling" EXACT []
synonym: "regulation by host of symbiont cAMP-mediated signaling" EXACT []
is_a: GO:0043949 ! regulation of cAMP-mediated signaling
is_a: GO:0052470 ! modulation by host of symbiont signal transduction pathway

[Term]
id: GO:0075206
name: positive regulation by host of symbiont cAMP-mediated signal transduction
namespace: biological_process
def: "Any process in which the host organism activates, maintains or increases the frequency, rate or extent of cAMP-mediated signal transduction in the symbiont organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "positive regulation by symbiont of host cAMP-mediated signal transduction ; GO:0075209".
synonym: "positive regulation by host of symbiont cAMP-mediated signaling" EXACT []
is_a: GO:0043950 ! positive regulation of cAMP-mediated signaling
is_a: GO:0052525 ! positive regulation by host of symbiont signal transduction pathway
is_a: GO:0075205 ! modulation by host of symbiont cAMP-mediated signal transduction

[Term]
id: GO:0075207
name: negative regulation by host of symbiont cAMP-mediated signal transduction
namespace: biological_process
def: "Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of cAMP-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "negative regulation by symbiont of host cAMP-mediated signal transduction ; GO:0075210".
synonym: "negative regulation by host of symbiont cAMP-mediated signaling" EXACT []
is_a: GO:0043951 ! negative regulation of cAMP-mediated signaling
is_a: GO:0052492 ! negative regulation by host of symbiont signal transduction pathway
is_a: GO:0075205 ! modulation by host of symbiont cAMP-mediated signal transduction

[Term]
id: GO:0075208
name: modulation by symbiont of host cAMP-mediated signal transduction
namespace: biological_process
def: "Any process in which the symbiont modulates the frequency, rate or extent of cAMP-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont cAMP-mediated signal transduction ; GO:0075205".
synonym: "modulation by symbiont of host cAMP-mediated signaling" EXACT []
is_a: GO:0043949 ! regulation of cAMP-mediated signaling
is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway

[Term]
id: GO:0075209
name: positive regulation by symbiont of host cAMP-mediated signal transduction
namespace: biological_process
def: "Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of cAMP-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont cAMP-mediated signal transduction ; GO:0075206".
synonym: "positive regulation by symbiont of host cAMP-mediated signaling" EXACT []
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0052028 ! positive regulation by symbiont of host signal transduction pathway
is_a: GO:0075208 ! modulation by symbiont of host cAMP-mediated signal transduction

[Term]
id: GO:0075210
name: negative regulation by symbiont of host cAMP-mediated signal transduction
namespace: biological_process
def: "Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of cAMP-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "Negative regulation by host of symbiont cAMP-mediated signal transduction ; GO:0075207".
synonym: "negative regulation by symbiont of host cAMP-mediated signaling" EXACT []
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0052029 ! negative regulation by symbiont of host signal transduction pathway
is_a: GO:0075208 ! modulation by symbiont of host cAMP-mediated signal transduction

[Term]
id: GO:0075211
name: regulation of transmembrane receptor-mediated cAMP signaling in response to host
namespace: biological_process
def: "Any process in which the symbiont organism modulates the frequency, rate or extent of its transmembrane receptor-mediated cAMP signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "regulation of symbiont transmembrane receptor-mediated cAMP signal transduction in response to host" EXACT []
synonym: "regulation of transmembrane receptor-mediated cAMP signal transduction in response to host" EXACT []
synonym: "regulation of transmembrane receptor-mediated cAMP signalling in response to host" EXACT []
is_a: GO:0075153 ! regulation of transmembrane receptor-mediated signal transduction in response to host
is_a: GO:0075174 ! regulation of cAMP-mediated signaling in response to host

[Term]
id: GO:0075212
name: positive regulation of transmembrane receptor-mediated cAMP signal transduction in response to host
namespace: biological_process
def: "Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its transmembrane receptor-mediated cAMP signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "positive regulation of symbiont transmembrane receptor-mediated cAMP signal transduction in response to host" RELATED []
is_a: GO:0075154 ! positive regulation of transmembrane receptor-mediated signal transduction in response to host
is_a: GO:0075175 ! positive regulation of cAMP-mediated signaling in response to host
is_a: GO:0075211 ! regulation of transmembrane receptor-mediated cAMP signaling in response to host

[Term]
id: GO:0075213
name: negative regulation of transmembrane receptor-mediated cAMP signal transduction in response to host
namespace: biological_process
def: "Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont transmembrane receptor-mediated cAMP signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "negative regulation of symbiont transmembrane receptor-mediated cAMP signal transduction in response to host" EXACT []
is_a: GO:0075155 ! negative regulation of transmembrane receptor-mediated signal transduction in response to host
is_a: GO:0075176 ! negative regulation of cAMP-mediated signaling in response to host
is_a: GO:0075211 ! regulation of transmembrane receptor-mediated cAMP signaling in response to host

[Term]
id: GO:0075214
name: spore encystment on host
namespace: biological_process
def: "The physiological, developmental and morphological changes that occur in a symbiont spore during the process of its encystment. Encystment means to enter a state of essentially suspended animation in which the spore is protected by an outer coating and remains immobile and inactive until favorable conditions for growth occur again. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:kmv, GOC:pamgo_curators]
is_a: GO:0022611 ! dormancy process
is_a: GO:0044132 ! development of symbiont on or near host

[Term]
id: GO:0075215
name: modulation of spore encystment on host
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of spore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0044138 ! modulation of development of symbiont on or near host
relationship: regulates GO:0075214 ! spore encystment on host

[Term]
id: GO:0075216
name: positive regulation of spore encystment on host
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of spore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0044143 ! positive regulation of development of symbiont on or near host surface
is_a: GO:0075215 ! modulation of spore encystment on host
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0075214 ! spore encystment on host
relationship: positively_regulates GO:0075214 ! spore encystment on host

[Term]
id: GO:0075217
name: negative regulation of spore encystment on host
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of spore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0044141 ! negative regulation of development of symbiont on or near host surface
is_a: GO:0075215 ! modulation of spore encystment on host
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0075214 ! spore encystment on host
relationship: negatively_regulates GO:0075214 ! spore encystment on host

[Term]
id: GO:0075218
name: zoospore encystment on host
namespace: biological_process
def: "The physiological, developmental and morphological changes that occur in a symbiont zoospore during the process of its encystment. Encystment means to enter a state of essentially suspended animation in which the spore is protected by an outer coating and remains immobile and inactive until favorable conditions for growth occur again. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0075214 ! spore encystment on host

[Term]
id: GO:0075219
name: modulation of zoospore encystment on host
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of zoospore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0075215 ! modulation of spore encystment on host
relationship: regulates GO:0075218 ! zoospore encystment on host

[Term]
id: GO:0075220
name: positive regulation of zoospore encystment on host
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of zoospore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0075216 ! positive regulation of spore encystment on host
is_a: GO:0075219 ! modulation of zoospore encystment on host
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0075218 ! zoospore encystment on host
relationship: positively_regulates GO:0075218 ! zoospore encystment on host

[Term]
id: GO:0075221
name: negative regulation of zoospore encystment on host
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of zoospore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0075217 ! negative regulation of spore encystment on host
is_a: GO:0075219 ! modulation of zoospore encystment on host
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0075218 ! zoospore encystment on host
relationship: negatively_regulates GO:0075218 ! zoospore encystment on host

[Term]
id: GO:0075222
name: sporangium germination on or near host
namespace: biological_process
def: "The physiological, developmental and morphological changes that occur in a symbiont sporangium following release from dormancy up to the earliest signs of growth occurring on or near its host organism. A sporangium is a structure producing and containing spores. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "direct germination on or near host" NARROW []
synonym: "germination of symbiont sporangium on or near host" EXACT []
synonym: "symbiont sporangium germination on or near host" EXACT []
is_a: GO:0043582 ! sporangium development
is_a: GO:0044132 ! development of symbiont on or near host
is_a: GO:0044703 ! multi-organism reproductive process

[Term]
id: GO:0075223
name: modulation of sporangium germination on or near host
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sporangium germination. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0044138 ! modulation of development of symbiont on or near host
is_a: GO:0075310 ! regulation of sporangium development
relationship: regulates GO:0075222 ! sporangium germination on or near host

[Term]
id: GO:0075224
name: positive regulation of sporangium germination on or near host
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of sporangium germination on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0044143 ! positive regulation of development of symbiont on or near host surface
is_a: GO:0075223 ! modulation of sporangium germination on or near host
is_a: GO:0075311 ! positive regulation of sporangium development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0075222 ! sporangium germination on or near host
relationship: positively_regulates GO:0075222 ! sporangium germination on or near host

[Term]
id: GO:0075225
name: negative regulation of sporangium germination on or near host
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sporangium germination on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0044141 ! negative regulation of development of symbiont on or near host surface
is_a: GO:0075223 ! modulation of sporangium germination on or near host
is_a: GO:0075312 ! negative regulation of sporangium development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0075222 ! sporangium germination on or near host
relationship: negatively_regulates GO:0075222 ! sporangium germination on or near host

[Term]
id: GO:0075226
name: encysted zoospore germination on or near host
namespace: biological_process
def: "The physiological, developmental and morphological changes that occur in the symbiont encysted zoospore, which is on or near its host organism and germinates by developing a germ tube that may penetrate the host directly or indirectly through an appresorium. An encysted zoospore is a zoospore which has shed its flagellum and whose membrane has fused to form a walled cyst. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0075005 ! spore germination on or near host

[Term]
id: GO:0075227
name: modulation of encysted zoospore germination on or near host
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of encysted zoospore germination on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0075006 ! modulation of spore germination on or near host
relationship: regulates GO:0075226 ! encysted zoospore germination on or near host

[Term]
id: GO:0075228
name: positive regulation of encysted zoospore germination on or near host
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of encysted zoospore germination on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0075007 ! positive regulation of spore germination on or near host
is_a: GO:0075227 ! modulation of encysted zoospore germination on or near host
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0075226 ! encysted zoospore germination on or near host
relationship: positively_regulates GO:0075226 ! encysted zoospore germination on or near host

[Term]
id: GO:0075229
name: negative regulation of encysted zoospore germination on or near host
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of encysted zoospore germination on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0075008 ! negative regulation of spore germination on or near host
is_a: GO:0075227 ! modulation of encysted zoospore germination on or near host
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0075226 ! encysted zoospore germination on or near host
relationship: negatively_regulates GO:0075226 ! encysted zoospore germination on or near host

[Term]
id: GO:0075230
name: spore movement on or near host
namespace: biological_process
def: "Any process involved in the directed movement of a motile spore on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0052127 ! movement on or near host

[Term]
id: GO:0075231
name: modulation of spore movement on or near host
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of spore movement on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0040012 ! regulation of locomotion
is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism
relationship: regulates GO:0075230 ! spore movement on or near host

[Term]
id: GO:0075232
name: positive regulation of spore movement on or near host
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of spore movement on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0040017 ! positive regulation of locomotion
is_a: GO:0043902 ! positive regulation of multi-organism process
is_a: GO:0075231 ! modulation of spore movement on or near host
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0075230 ! spore movement on or near host
relationship: positively_regulates GO:0075230 ! spore movement on or near host

[Term]
id: GO:0075233
name: negative regulation of spore movement on or near host
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of spore movement on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0040013 ! negative regulation of locomotion
is_a: GO:0043901 ! negative regulation of multi-organism process
is_a: GO:0075231 ! modulation of spore movement on or near host
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0075230 ! spore movement on or near host
relationship: negatively_regulates GO:0075230 ! spore movement on or near host

[Term]
id: GO:0075234
name: zoospore movement on or near host
namespace: biological_process
def: "Any process involved in the directed movement of a zoospore on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "zoospore motility on or near host" EXACT []
is_a: GO:0075230 ! spore movement on or near host

[Term]
id: GO:0075235
name: modulation of zoospore movement on or near host
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of zoospore movement on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "regulation of zoospore motility on or near host" EXACT []
is_a: GO:0075231 ! modulation of spore movement on or near host
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0075234 ! zoospore movement on or near host
relationship: regulates GO:0075234 ! zoospore movement on or near host

[Term]
id: GO:0075236
name: positive regulation of zoospore movement on or near host
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of zoospore movement on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0075232 ! positive regulation of spore movement on or near host
is_a: GO:0075235 ! modulation of zoospore movement on or near host
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0075234 ! zoospore movement on or near host
relationship: positively_regulates GO:0075234 ! zoospore movement on or near host

[Term]
id: GO:0075237
name: negative regulation of zoospore movement on or near host
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of zoospore movement on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0075233 ! negative regulation of spore movement on or near host
is_a: GO:0075235 ! modulation of zoospore movement on or near host
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0075234 ! zoospore movement on or near host
relationship: negatively_regulates GO:0075234 ! zoospore movement on or near host

[Term]
id: GO:0075238
name: maintenance of symbiont tolerance to host pH environment
namespace: biological_process
def: "Any process that contributes to the maintenance of a physiologic state in which the symbiont immune system does not react destructively against pH environment of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
is_a: GO:0075141 ! maintenance of symbiont tolerance to host environment
is_a: GO:0075293 ! response to host pH environment

[Term]
id: GO:0075239
name: zoospore formation
namespace: biological_process
def: "The process in which a diploid cell undergoes meiosis, and the meiotic products acquire specialized features of asexual motile mononucleate flagellated spores called zoospores." [GOC:pamgo_curators]
is_a: GO:0034300 ! sporangiospore formation

[Term]
id: GO:0075240
name: regulation of zoospore formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of zoospore formation, a process in which a diploid cell undergoes meiosis, and the meiotic products acquire specialized features of asexual motile mononucleate flagellated spores called zoospores." [GOC:pamgo_curators]
is_a: GO:0075286 ! regulation of sporangiospore formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0075239 ! zoospore formation
relationship: regulates GO:0075239 ! zoospore formation

[Term]
id: GO:0075241
name: positive regulation of zoospore formation
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of zoospore formation, a process in which a diploid cell undergoes meiosis, and the meiotic products acquire specialized features of asexual motile mononucleate flagellated spores called zoospores." [GOC:pamgo_curators]
is_a: GO:0075240 ! regulation of zoospore formation
is_a: GO:0075287 ! positive regulation of sporangiospore formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0075239 ! zoospore formation
relationship: positively_regulates GO:0075239 ! zoospore formation

[Term]
id: GO:0075242
name: negative regulation of zoospore formation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of zoospore formation, a process in which a diploid cell undergoes meiosis, and the meiotic products acquire specialized features of asexual motile mononucleate flagellated spores called zoospores." [GOC:pamgo_curators]
is_a: GO:0075240 ! regulation of zoospore formation
is_a: GO:0075288 ! negative regulation of sporangiospore formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0075239 ! zoospore formation
relationship: negatively_regulates GO:0075239 ! zoospore formation

[Term]
id: GO:0075243
name: oospore formation
namespace: biological_process
def: "The process in which male and female gametangia develop and fuse to form an oospore, a thick-walled resting spore of oomycetes." [GOC:pamgo_curators]
is_a: GO:0043935 ! sexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0075244
name: regulation of oospore formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of oospore formation, a process in which male and female gametangia develop and fuse to form a thick-walled resting spore of oomycetes." [GOC:pamgo_curators]
is_a: GO:0043940 ! regulation of sexual sporulation resulting in formation of a cellular spore
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0075243 ! oospore formation
relationship: regulates GO:0075243 ! oospore formation

[Term]
id: GO:0075245
name: positive regulation of oospore formation
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of oospore formation, a process in which male and female gametangia develop and fuse to form a thick-walled resting spore of oomycetes." [GOC:pamgo_curators]
is_a: GO:0043941 ! positive regulation of sexual sporulation resulting in formation of a cellular spore
is_a: GO:0075244 ! regulation of oospore formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0075243 ! oospore formation
relationship: positively_regulates GO:0075243 ! oospore formation

[Term]
id: GO:0075246
name: negative regulation of oospore formation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of oospore formation, a process in which male and female gametangia develop and fuse to form a thick-walled resting spore of oomycetes." [GOC:pamgo_curators]
is_a: GO:0043942 ! negative regulation of sexual sporulation resulting in formation of a cellular spore
is_a: GO:0075244 ! regulation of oospore formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0075243 ! oospore formation
relationship: negatively_regulates GO:0075243 ! oospore formation

[Term]
id: GO:0075247
name: aeciospore formation
namespace: biological_process
def: "The process in which a dikaryotic spore of typically a rust fungus is produced in an aecium; in heteroecious rusts, the aeciospore is a spore stage that infects the alternate host." [GOC:pamgo_curators]
is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0075248
name: regulation of aeciospore formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of aeciospore formation, a process in which a dikaryotic spore of typically a rust fungus is produced in an aecium." [GOC:pamgo_curators]
is_a: GO:0043943 ! regulation of asexual sporulation resulting in formation of a cellular spore
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0075247 ! aeciospore formation
relationship: regulates GO:0075247 ! aeciospore formation

[Term]
id: GO:0075249
name: positive regulation of aeciospore formation
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of aeciospore formation, a process in which a dikaryotic spore of typically a rust fungus is produced in an aecium." [GOC:pamgo_curators]
is_a: GO:0043945 ! positive regulation of asexual sporulation resulting in formation of a cellular spore
is_a: GO:0075248 ! regulation of aeciospore formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0075247 ! aeciospore formation
relationship: positively_regulates GO:0075247 ! aeciospore formation

[Term]
id: GO:0075250
name: negative regulation of aeciospore formation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of aeciospore formation, a process in which a dikaryotic spore of typically a rust fungus is produced in an aecium." [GOC:pamgo_curators]
is_a: GO:0043944 ! negative regulation of asexual sporulation resulting in formation of a cellular spore
is_a: GO:0075248 ! regulation of aeciospore formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0075247 ! aeciospore formation
relationship: negatively_regulates GO:0075247 ! aeciospore formation

[Term]
id: GO:0075251
name: uredospore formation
namespace: biological_process
def: "The process which specific outcome is the formation of an asexual, dikaryotic, often rusty-colored spore, produced in a structure called a uredinium; mostly found in the rust fungus." [GOC:pamgo_curators]
synonym: "urediniospore formation" EXACT []
synonym: "ureidospore formation" EXACT []
is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0075252
name: regulation of uredospore formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of uredospore formation, a process in which an asexual, dikaryotic, often rusty-colored spore, is formed in a structure called a uredinium." [GOC:pamgo_curators]
synonym: "regulation of ureidospore formation" EXACT []
is_a: GO:0043943 ! regulation of asexual sporulation resulting in formation of a cellular spore
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0075251 ! uredospore formation
relationship: regulates GO:0075251 ! uredospore formation

[Term]
id: GO:0075253
name: positive regulation of uredospore formation
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of uredospore formation, a process in which an asexual, dikaryotic, often rusty-colored spore, is formed in a structure called a uredinium." [GOC:pamgo_curators]
synonym: "positive regulation of ureidospore formation" EXACT []
is_a: GO:0043945 ! positive regulation of asexual sporulation resulting in formation of a cellular spore
is_a: GO:0075252 ! regulation of uredospore formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0075251 ! uredospore formation
relationship: positively_regulates GO:0075251 ! uredospore formation

[Term]
id: GO:0075254
name: negative regulation of uredospore formation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of uredospore formation, a process in which an asexual, dikaryotic, often rusty-colored spore, is formed in a structure called a uredinium." [GOC:pamgo_curators]
synonym: "negative regulation of ureidospore formation" EXACT []
is_a: GO:0043944 ! negative regulation of asexual sporulation resulting in formation of a cellular spore
is_a: GO:0075252 ! regulation of uredospore formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0075251 ! uredospore formation
relationship: negatively_regulates GO:0075251 ! uredospore formation

[Term]
id: GO:0075255
name: teliospore formation
namespace: biological_process
def: "The set of processes leading to the formation of a thick-walled resting or over-wintering spore produced by the rust fungi (Uredinales) and smut fungi (Ustilaginales) in which karyogamy occurs." [GOC:pamgo_curators]
is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0075256
name: regulation of teliospore formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of teliospore formation, which is the formation of a thick-walled resting or over-wintering spore produced by the rust fungi (Uredinales) and smut fungi (Ustilaginales) in which karyogamy occurs." [GOC:pamgo_curators]
is_a: GO:0043943 ! regulation of asexual sporulation resulting in formation of a cellular spore
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0075255 ! teliospore formation
relationship: regulates GO:0075255 ! teliospore formation

[Term]
id: GO:0075257
name: positive regulation of teliospore formation
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of teliospore formation, which is the formation of a thick-walled resting or overwintering spore produced by the rust fungi (Uredinales) and smut fungi (Ustilaginales) in which karyogamy occurs." [GOC:pamgo_curators]
is_a: GO:0043945 ! positive regulation of asexual sporulation resulting in formation of a cellular spore
is_a: GO:0075256 ! regulation of teliospore formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0075255 ! teliospore formation
relationship: positively_regulates GO:0075255 ! teliospore formation

[Term]
id: GO:0075258
name: negative regulation of teliospore formation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of teliospore formation, which is the formation of a thick-walled resting or overwintering spore produced by the rust fungi (Uredinales) and smut fungi (Ustilaginales) in which karyogamy occurs." [GOC:pamgo_curators]
is_a: GO:0043944 ! negative regulation of asexual sporulation resulting in formation of a cellular spore
is_a: GO:0075256 ! regulation of teliospore formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0075255 ! teliospore formation
relationship: negatively_regulates GO:0075255 ! teliospore formation

[Term]
id: GO:0075259
name: spore-bearing organ development
namespace: biological_process
def: "The process whose specific outcome is the progression of a spore-bearing organ over time, from its formation to the mature structure. A spore-bearing organ is an anatomical structure that produces new spores." [GOC:mah, GOC:mcc, GOC:pamgo_curators]
synonym: "fruiting structure development" EXACT []
is_a: GO:0048513 ! animal organ development
is_a: GO:0048608 ! reproductive structure development

[Term]
id: GO:0075260
name: regulation of spore-bearing organ development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of spore-bearing organ development, a process in which hyphae grow into special aggregates called fruiting bodies that produce new spores." [GOC:pamgo_curators]
is_a: GO:2000026 ! regulation of multicellular organismal development
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0075259 ! spore-bearing organ development
relationship: regulates GO:0075259 ! spore-bearing organ development

[Term]
id: GO:0075261
name: positive regulation of spore-bearing organ development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of spore-bearing organ development, a process in which hyphae grow into special aggregates called fruiting bodies that produce new spores." [GOC:pamgo_curators]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0075260 ! regulation of spore-bearing organ development
is_a: GO:2000243 ! positive regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0075259 ! spore-bearing organ development
relationship: positively_regulates GO:0075259 ! spore-bearing organ development

[Term]
id: GO:0075262
name: negative regulation of spore-bearing organ development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of spore-bearing organ development, a process in which hyphae grow into special aggregates called fruiting bodies that produce new spores." [GOC:pamgo_curators]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0075260 ! regulation of spore-bearing organ development
is_a: GO:2000242 ! negative regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0075259 ! spore-bearing organ development
relationship: negatively_regulates GO:0075259 ! spore-bearing organ development

[Term]
id: GO:0075263
name: oogonium development
namespace: biological_process
def: "The process that leads to the development of an oogonium, a female gametangium of Oomycetes, containing one or more gametes." [GOC:pamgo_curators]
is_a: GO:0075259 ! spore-bearing organ development

[Term]
id: GO:0075264
name: regulation of oogonium development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of oogonium development, a process that leads to the formation of a female gametangium of oomycetes, containing one or more gametes." [GOC:pamgo_curators]
is_a: GO:0075260 ! regulation of spore-bearing organ development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0075263 ! oogonium development
relationship: regulates GO:0075263 ! oogonium development

[Term]
id: GO:0075265
name: positive regulation of oogonium development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of oogonium development, a process that leads to the formation of a female gametangium of oomycetes, containing one or more gametes." [GOC:pamgo_curators]
is_a: GO:0075261 ! positive regulation of spore-bearing organ development
is_a: GO:0075264 ! regulation of oogonium development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0075263 ! oogonium development
relationship: positively_regulates GO:0075263 ! oogonium development

[Term]
id: GO:0075266
name: negative regulation of oogonium development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of oogonium development, a process that leads to the formation of a female gametangium of oomycetes, containing one or more gametes." [GOC:pamgo_curators]
is_a: GO:0075262 ! negative regulation of spore-bearing organ development
is_a: GO:0075264 ! regulation of oogonium development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0075263 ! oogonium development
relationship: negatively_regulates GO:0075263 ! oogonium development

[Term]
id: GO:0075267
name: aecium development
namespace: biological_process
def: "The process in which a cup-like structure containing chains of aeciospores is formed. This is characteristic of the rust fungus and typically, the first dikaryotic spores (aeciospores) are produced in the aecium." [GOC:pamgo_curators]
is_a: GO:0030582 ! fruiting body development

[Term]
id: GO:0075268
name: regulation of aecium development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of aecium development, a process in which a cuplike structure containing chains of aeciospores is formed." [GOC:pamgo_curators]
is_a: GO:0031155 ! regulation of fruiting body development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0075267 ! aecium development
relationship: regulates GO:0075267 ! aecium development

[Term]
id: GO:0075269
name: positive regulation of aecium development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of aecium development, a process in which a cuplike structure containing chains of aeciospores is formed." [GOC:pamgo_curators]
is_a: GO:0075261 ! positive regulation of spore-bearing organ development
is_a: GO:0075268 ! regulation of aecium development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0075267 ! aecium development
relationship: positively_regulates GO:0075267 ! aecium development

[Term]
id: GO:0075270
name: negative regulation of aecium development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of aecium development, a process in which a cuplike structure containing chains of aeciospores is formed." [GOC:pamgo_curators]
is_a: GO:0075262 ! negative regulation of spore-bearing organ development
is_a: GO:0075268 ! regulation of aecium development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0075267 ! aecium development
relationship: negatively_regulates GO:0075267 ! aecium development

[Term]
id: GO:0075271
name: zygosporangium development
namespace: biological_process
def: "The process in which a fruiting body called zygosporangium is formed. A zygosporangium is a thick-walled structure in which spores are produced, and is characteristic of the Zygomycetes." [GOC:pamgo_curators]
is_a: GO:0075259 ! spore-bearing organ development

[Term]
id: GO:0075272
name: regulation of zygosporangium development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of zygosporangium development, a process in which a fruiting body called zygosporangium is formed." [GOC:pamgo_curators]
is_a: GO:0075260 ! regulation of spore-bearing organ development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0075271 ! zygosporangium development
relationship: regulates GO:0075271 ! zygosporangium development

[Term]
id: GO:0075273
name: positive regulation of zygosporangium development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of zygosporangium development, a process in which a fruiting body called zygosporangium is formed." [GOC:pamgo_curators]
is_a: GO:0075261 ! positive regulation of spore-bearing organ development
is_a: GO:0075272 ! regulation of zygosporangium development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0075271 ! zygosporangium development
relationship: positively_regulates GO:0075271 ! zygosporangium development

[Term]
id: GO:0075274
name: negative regulation of zygosporangium development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of zygosporangium development, a process in which a fruiting body called zygosporangium is formed." [GOC:pamgo_curators]
is_a: GO:0075262 ! negative regulation of spore-bearing organ development
is_a: GO:0075272 ! regulation of zygosporangium development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0075271 ! zygosporangium development
relationship: negatively_regulates GO:0075271 ! zygosporangium development

[Term]
id: GO:0075275
name: telium development
namespace: biological_process
def: "The process that leads to the development of a telium, which is a teliospore-bearing sorus of the rust fungi." [GOC:pamgo_curators]
is_a: GO:0075259 ! spore-bearing organ development

[Term]
id: GO:0075276
name: regulation of telium development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of telium development, a process that leads to the formation of a teliospore-bearing sorus of the rust fungi." [GOC:pamgo_curators]
is_a: GO:0075260 ! regulation of spore-bearing organ development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0075275 ! telium development
relationship: regulates GO:0075275 ! telium development

[Term]
id: GO:0075277
name: positive regulation of telium development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of telium development, a process that leads to the formation of a teliospore-bearing sorus of the rust fungi." [GOC:pamgo_curators]
is_a: GO:0075261 ! positive regulation of spore-bearing organ development
is_a: GO:0075276 ! regulation of telium development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0075275 ! telium development
relationship: positively_regulates GO:0075275 ! telium development

[Term]
id: GO:0075278
name: negative regulation of telium development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of telium development, a process that leads to the formation of a teliospore-bearing sorus of the rust fungi." [GOC:pamgo_curators]
is_a: GO:0075262 ! negative regulation of spore-bearing organ development
is_a: GO:0075276 ! regulation of telium development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0075275 ! telium development
relationship: negatively_regulates GO:0075275 ! telium development

[Term]
id: GO:0075279
name: uredinium development
namespace: biological_process
def: "The process that leads to the formation of a uredinium, a reddish, pustule-like structure formed by a rust fungus and consisting of uredospores." [GOC:pamgo_curators]
synonym: "development of uredium" EXACT []
is_a: GO:0075259 ! spore-bearing organ development

[Term]
id: GO:0075280
name: regulation of uredinium development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of uredinium development, a process that leads to the formation of a reddish, pustule-like structure formed by a rust fungus and consisting of uredospores." [GOC:pamgo_curators]
is_a: GO:0075260 ! regulation of spore-bearing organ development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0075279 ! uredinium development
relationship: regulates GO:0075279 ! uredinium development

[Term]
id: GO:0075281
name: positive regulation of uredinium development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of uredinium development, a process that leads to the formation of a reddish, pustule-like structure formed by a rust fungus and consisting of uredospores." [GOC:pamgo_curators]
is_a: GO:0075261 ! positive regulation of spore-bearing organ development
is_a: GO:0075280 ! regulation of uredinium development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0075279 ! uredinium development
relationship: positively_regulates GO:0075279 ! uredinium development

[Term]
id: GO:0075282
name: negative regulation of uredinium development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of uredinium development, a process that leads to the formation of a reddish, pustule-like structure formed by a rust fungus and consisting of uredospores." [GOC:pamgo_curators]
is_a: GO:0075262 ! negative regulation of spore-bearing organ development
is_a: GO:0075280 ! regulation of uredinium development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0075279 ! uredinium development
relationship: negatively_regulates GO:0075279 ! uredinium development

[Term]
id: GO:0075283
name: sporulation resulting in formation of a multicellular or syncytial spore
namespace: biological_process
def: "The process whose specific outcome is the progression of a multicellular or syncytial spore via septations over time, from its initiation to the mature structure." [GOC:pamgo_curators]
synonym: "multicellular or syncytial spore formation by sporulation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0043934 ! sporulation

[Term]
id: GO:0075284
name: asexual sporulation resulting in formation of a multicellular or syncytial spore
namespace: biological_process
def: "The formation of a multicellular or syncytial spore via septations derived from mitosis." [GOC:pamgo_curators]
is_a: GO:0030436 ! asexual sporulation
is_a: GO:0075283 ! sporulation resulting in formation of a multicellular or syncytial spore

[Term]
id: GO:0075285
name: sexual sporulation resulting in formation of a multicellular or syncytial spore
namespace: biological_process
def: "The formation of multicellular or syncytial spore via septations derived from meiosis. A multicellular or syncytial spore is a structure that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction." [GOC:pamgo_curators]
is_a: GO:0034293 ! sexual sporulation
is_a: GO:0075283 ! sporulation resulting in formation of a multicellular or syncytial spore
intersection_of: GO:0075283 ! sporulation resulting in formation of a multicellular or syncytial spore
intersection_of: part_of GO:0051321 ! meiotic cell cycle
relationship: part_of GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0075286
name: regulation of sporangiospore formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sporangiospore formation, a process in which sporangiospores, a type of asexual spore found in fungi, are formed. Sporangiospores are formed within sac-like structure, the sporangium, following the division of the cytoplasm." [GOC:pamgo_curators]
is_a: GO:0043943 ! regulation of asexual sporulation resulting in formation of a cellular spore
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034300 ! sporangiospore formation
relationship: regulates GO:0034300 ! sporangiospore formation

[Term]
id: GO:0075287
name: positive regulation of sporangiospore formation
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of sporangiospore formation, a process in which sporangiospores, a type of asexual spore found in fungi, are formed. Sporangiospores are formed within sac-like structure, the sporangium, following the division of the cytoplasm." [GOC:pamgo_curators]
is_a: GO:0043945 ! positive regulation of asexual sporulation resulting in formation of a cellular spore
is_a: GO:0075286 ! regulation of sporangiospore formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034300 ! sporangiospore formation
relationship: positively_regulates GO:0034300 ! sporangiospore formation

[Term]
id: GO:0075288
name: negative regulation of sporangiospore formation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sporangiospore formation, a process in which sporangiospores, a type of asexual spore found in fungi, are formed. Sporangiospores are formed within sac-like structure, the sporangium, following the division of the cytoplasm." [GOC:pamgo_curators]
is_a: GO:0043944 ! negative regulation of asexual sporulation resulting in formation of a cellular spore
is_a: GO:0075286 ! regulation of sporangiospore formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034300 ! sporangiospore formation
relationship: negatively_regulates GO:0034300 ! sporangiospore formation

[Term]
id: GO:0075289
name: aplanospore formation
namespace: biological_process
def: "The process in which a nonmotile, asexual spore is formed within a cell in certain algae and fungi (commonly in the Phycomycetes), the wall of aplanospore is distinct from that of the parent cell." [GOC:pamgo_curators]
is_a: GO:0034300 ! sporangiospore formation

[Term]
id: GO:0075290
name: regulation of aplanospore formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of aplanospore formation, a process in which a nonmotile, asexual spore is formed within a cell in certain algae and fungi (commonly in the Phycomycetes), the wall of aplanospore is distinct from that of the parent cell." [GOC:pamgo_curators]
is_a: GO:0075286 ! regulation of sporangiospore formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0075289 ! aplanospore formation
relationship: regulates GO:0075289 ! aplanospore formation

[Term]
id: GO:0075291
name: positive regulation of aplanospore formation
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of aplanospore formation, a process in which a nonmotile, asexual spore is formed within a cell in certain algae and fungi (commonly in the Phycomycetes), the wall of aplanospore is distinct from that of the parent cell." [GOC:pamgo_curators]
is_a: GO:0075287 ! positive regulation of sporangiospore formation
is_a: GO:0075290 ! regulation of aplanospore formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0075289 ! aplanospore formation
relationship: positively_regulates GO:0075289 ! aplanospore formation

[Term]
id: GO:0075292
name: negative regulation of aplanospore formation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of aplanospore formation, a process in which a nonmotile, asexual spore is formed within a cell in certain algae and fungi (commonly in the Phycomycetes), the wall of aplanospore is distinct from that of the parent cell." [GOC:pamgo_curators]
is_a: GO:0075288 ! negative regulation of sporangiospore formation
is_a: GO:0075290 ! regulation of aplanospore formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0075289 ! aplanospore formation
relationship: negatively_regulates GO:0075289 ! aplanospore formation

[Term]
id: GO:0075293
name: response to host pH environment
namespace: biological_process
def: "Any process that results in a change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the pH conditions in or around its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "response of symbiont to host pH environment" EXACT []
is_a: GO:0075136 ! response to host

[Term]
id: GO:0075294
name: positive regulation by symbiont of entry into host
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent to which it enters into the host organism, where the two organisms are in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "activation by symbiont of entry into host" NARROW []
synonym: "up regulation by symbiont of entry into host" EXACT []
synonym: "up-regulation by symbiont of entry into host" EXACT []
synonym: "upregulation by symbiont of entry into host" EXACT []
is_a: GO:0052372 ! modulation by symbiont of entry into host
is_a: GO:0075295 ! positive regulation by organism of entry into other organism involved in symbiotic interaction

[Term]
id: GO:0075295
name: positive regulation by organism of entry into other organism involved in symbiotic interaction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent to which it enters into a second organism, where the two organisms are in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "activation by organism of entry into other organism during symbiotic interaction" NARROW []
synonym: "positive regulation by organism of entry into other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "up regulation by organism of entry into other organism during symbiotic interaction" RELATED []
synonym: "up-regulation by organism of entry into other organism during symbiotic interaction" RELATED []
synonym: "upregulation by organism of entry into other organism during symbiotic interaction" RELATED []
is_a: GO:0043902 ! positive regulation of multi-organism process
is_a: GO:0052371 ! regulation by organism of entry into other organism involved in symbiotic interaction

[Term]
id: GO:0075296
name: positive regulation of ascospore formation
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of ascospore formation, a process in which a sexual spore, named ascospore, from Ascomycete fungi was produced inside an ascus." [GOC:pamgo_curators]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0034307 ! regulation of ascospore formation
is_a: GO:0043941 ! positive regulation of sexual sporulation resulting in formation of a cellular spore
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030437 ! ascospore formation
relationship: positively_regulates GO:0030437 ! ascospore formation

[Term]
id: GO:0075297
name: negative regulation of ascospore formation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ascospore formation, a process in which a sexual spore, named ascospore, from Ascomycete fungi was produced inside an ascus." [GOC:pamgo_curators]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0034307 ! regulation of ascospore formation
is_a: GO:0043942 ! negative regulation of sexual sporulation resulting in formation of a cellular spore
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030437 ! ascospore formation
relationship: negatively_regulates GO:0030437 ! ascospore formation

[Term]
id: GO:0075298
name: regulation of zygospore formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of zygospore formation, a process in which a thick-walled spore of some algae and fungi is formed by union of two similar sexual cells, usually serves as a resting spore, and produces the sporophytic phase." [GOC:pamgo_curators]
is_a: GO:0043940 ! regulation of sexual sporulation resulting in formation of a cellular spore
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034296 ! zygospore formation
relationship: regulates GO:0034296 ! zygospore formation

[Term]
id: GO:0075299
name: positive regulation of zygospore formation
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of frequency, rate or extent of zygospore formation, a process in which a thick-walled spore of some algae and fungi is formed by union of two similar sexual cells, usually serves as a resting spore, and produces the sporophytic phase." [GOC:pamgo_curators]
is_a: GO:0043941 ! positive regulation of sexual sporulation resulting in formation of a cellular spore
is_a: GO:0075298 ! regulation of zygospore formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034296 ! zygospore formation
relationship: positively_regulates GO:0034296 ! zygospore formation

[Term]
id: GO:0075300
name: negative regulation of zygospore formation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of zygospore formation, a process in which a thick-walled spore of some algae and fungi is formed by union of two similar sexual cells, usually serves as a resting spore, and produces the sporophytic phase." [GOC:pamgo_curators]
is_a: GO:0043942 ! negative regulation of sexual sporulation resulting in formation of a cellular spore
is_a: GO:0075298 ! regulation of zygospore formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034296 ! zygospore formation
relationship: negatively_regulates GO:0034296 ! zygospore formation

[Term]
id: GO:0075301
name: cell differentiation involved in spore germination
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a specific cell type occurring during spore germination, the physiological and developmental changes that occur in a spore following release from dormancy up to the earliest signs of growth." [GOC:jl]
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: part_of GO:0009847 ! spore germination
relationship: part_of GO:0009847 ! spore germination

[Term]
id: GO:0075302
name: regulation of basidiospore formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of basidiospore formation, a process in which a sexually produced fungal spore is formed on a basidium in the fungi Basidiomycetes." [GOC:pamgo_curators]
is_a: GO:0043940 ! regulation of sexual sporulation resulting in formation of a cellular spore
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034295 ! basidiospore formation
relationship: regulates GO:0034295 ! basidiospore formation

[Term]
id: GO:0075303
name: positive regulation of basidiospore formation
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of frequency, rate or extent of basidiospore formation, a process in which a sexually produced fungal spore is formed on a basidium in the fungi basidiomycetes." [GOC:pamgo_curators]
is_a: GO:0043941 ! positive regulation of sexual sporulation resulting in formation of a cellular spore
is_a: GO:0075302 ! regulation of basidiospore formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034295 ! basidiospore formation
relationship: positively_regulates GO:0034295 ! basidiospore formation

[Term]
id: GO:0075304
name: negative regulation of basidiospore formation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of basidiospore formation, a process in which a sexually produced fungal spore is formed on a basidium in the fungi basidiomycetes." [GOC:pamgo_curators]
is_a: GO:0043942 ! negative regulation of sexual sporulation resulting in formation of a cellular spore
is_a: GO:0075302 ! regulation of basidiospore formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034295 ! basidiospore formation
relationship: negatively_regulates GO:0034295 ! basidiospore formation

[Term]
id: GO:0075305
name: obsolete modulation of growth or development of symbiont on or near host
namespace: biological_process
def: "OBSOLETE. Any process by which the symbiont regulates the increase in its size or mass, or its progression from an initial condition to a later condition, on or near the cells or tissues of the host organism." [GOC:pamgo_curators]
comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'modulation of growth of symbiont on or near host ; GO:0044139' and 'modulation of development of symbiont on or near host ; GO:0044138'.
synonym: "modulation of growth or development of symbiont on or near host" EXACT []
synonym: "modulation of growth or development of symbiont on or near host surface" EXACT []
is_obsolete: true
consider: GO:0044138
consider: GO:0044139

[Term]
id: GO:0075306
name: regulation of conidium formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of conidium formation, a processes leading to the production of a type of asexual non-motile reproductive spore of fungi via mitosis at the tip or side of hyphae or on special spore-producing structures called conidiophores." [GOC:pamgo_curators]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0034305 ! regulation of asexual sporulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048315 ! conidium formation
relationship: regulates GO:0048315 ! conidium formation

[Term]
id: GO:0075307
name: positive regulation of conidium formation
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of conidium formation, a processes leading to the production of a type of asexual non-motile reproductive spore of fungi via mitosis at the tip or side of hyphae or on special spore-producing structures called conidiophores." [GOC:pamgo_curators]
is_a: GO:0043938 ! positive regulation of sporulation
is_a: GO:0075306 ! regulation of conidium formation
is_a: GO:1903666 ! positive regulation of asexual reproduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048315 ! conidium formation
relationship: positively_regulates GO:0048315 ! conidium formation

[Term]
id: GO:0075308
name: negative regulation of conidium formation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of conidium formation, a processes leading to the production of a type of asexual non-motile reproductive spore of fungi via mitosis at the tip or side of hyphae or on special spore-producing structures called conidiophores." [GOC:pamgo_curators]
is_a: GO:0043939 ! negative regulation of sporulation
is_a: GO:0075306 ! regulation of conidium formation
is_a: GO:1903665 ! negative regulation of asexual reproduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048315 ! conidium formation
relationship: negatively_regulates GO:0048315 ! conidium formation

[Term]
id: GO:0075309
name: obsolete negative regulation of growth or development of symbiont on or near host surface
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the increase in the symbiont's size or mass, or its progression from an initial condition to a later condition, on or near the cells or tissues of the host organism." [GOC:pamgo_curators]
comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'negative regulation of development of symbiont on or near host surface ; GO:0044141' and 'negative regulation of growth of symbiont on or near host surface ; GO:0044140'.
synonym: "negative regulation of growth or development of symbiont on or near host surface" EXACT []
is_obsolete: true
consider: GO:0044140
consider: GO:0044141

[Term]
id: GO:0075310
name: regulation of sporangium development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sporangium development, a process that leads to the formation of sporangium, a single-celled or many-celled structure in which spores are produced, as in fungi, algae, mosses, and ferns, gymnosperms, angiosperms." [GOC:pamgo_curators]
is_a: GO:0075260 ! regulation of spore-bearing organ development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043582 ! sporangium development
relationship: regulates GO:0043582 ! sporangium development

[Term]
id: GO:0075311
name: positive regulation of sporangium development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of sporangium development, a process that leads to the formation of sporangium, a single-celled or many-celled structure in which spores are produced, as in fungi, algae, mosses, and ferns, gymnosperms, angiosperms." [GOC:pamgo_curators]
is_a: GO:0075261 ! positive regulation of spore-bearing organ development
is_a: GO:0075310 ! regulation of sporangium development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043582 ! sporangium development
relationship: positively_regulates GO:0043582 ! sporangium development

[Term]
id: GO:0075312
name: negative regulation of sporangium development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sporangium development, a process that leads to the formation of sporangium, a single-celled or many-celled structure in which spores are produced, as in fungi, algae, mosses, and ferns, gymnosperms, angiosperms." [GOC:pamgo_curators]
is_a: GO:0075262 ! negative regulation of spore-bearing organ development
is_a: GO:0075310 ! regulation of sporangium development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043582 ! sporangium development
relationship: negatively_regulates GO:0043582 ! sporangium development

[Term]
id: GO:0075313
name: basidium development
namespace: biological_process
def: "The process that leads to the development of basidium, a small, specialized club-shaped structure typically bearing four basidiospores at the tips of minute projections. The basidium is unique to Basidiomycetes and distinguishes them from other kinds of fungi." [GOC:di, GOC:mah, GOC:mcc, GOC:pamgo_curators]
comment: Note that basidiospores and basidia are separate biological structures. The basidium is the structure that bear the basidiospores, but the development of the basidium is a different process than the formation of the basidiospores themselves. For this reason, GO:0034295 basidiospore formation and GO:0075313 basidium development are different terms and are not linked.
is_a: GO:0075259 ! spore-bearing organ development

[Term]
id: GO:0075314
name: regulation of basidium development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of basidium development, a process that leads to the formation of a basidium, a small, specialized club-shaped structure typically bearing four basidiospores at the tips of minute projections. The basidium is unique to Basidiomycetes and distinguishes them from other kinds of fungi." [GOC:pamgo_curators]
is_a: GO:0075260 ! regulation of spore-bearing organ development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0075313 ! basidium development
relationship: regulates GO:0075313 ! basidium development

[Term]
id: GO:0075315
name: positive regulation of basidium development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of basidium development, a process that leads to the formation of basidium, a small, specialized club-shaped structure typically bearing four basidiospores at the tips of minute projections. The basidium is unique to basidiomycetes and distinguishes them from other kinds of fungi." [GOC:pamgo_curators]
is_a: GO:0075261 ! positive regulation of spore-bearing organ development
is_a: GO:0075314 ! regulation of basidium development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0075313 ! basidium development
relationship: positively_regulates GO:0075313 ! basidium development

[Term]
id: GO:0075316
name: negative regulation of basidium development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of basidium development, a process that leads to the formation of basidium, a small, specialized club-shaped structure typically bearing four basidiospores at the tips of minute projections. The basidium is unique to basidiomycetes and distinguishes them from other kinds of fungi." [GOC:pamgo_curators]
is_a: GO:0075262 ! negative regulation of spore-bearing organ development
is_a: GO:0075314 ! regulation of basidium development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0075313 ! basidium development
relationship: negatively_regulates GO:0075313 ! basidium development

[Term]
id: GO:0075317
name: ascus development
namespace: biological_process
def: "The process that leads to the development of ascus, a sac-like structure produced by fungi of the phylum Ascomycota (sac fungi) in which sexually produced spores (ascospores), usually four or eight in number, are formed." [GOC:di, GOC:mah, GOC:mcc, GOC:pamgo_curators]
comment: Note that ascospores and asci are separate biological structures. The ascus is the structure that contain the ascospores, but the development of the ascus is a different process than the formation of the ascospores themselves; for instance, some mutations affect sporulation without affecting ascus development. For this reason, GO:0030437 ascospore formation and GO:0075317 ascus development are different terms and are not linked.
is_a: GO:0075259 ! spore-bearing organ development

[Term]
id: GO:0075318
name: regulation of ascus development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ascus development, a process that leads to the formation of basidium, a sac-like structure produced by fungi of the phylum Ascomycota (sac fungi) in which sexually produced spores (ascospores), usually four or eight in number, are formed." [GOC:pamgo_curators]
is_a: GO:0075260 ! regulation of spore-bearing organ development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0075317 ! ascus development
relationship: regulates GO:0075317 ! ascus development

[Term]
id: GO:0075319
name: positive regulation of ascus development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of ascus development, a saclike structure produced by fungi of the phylum Ascomycota (sac fungi) in which sexually produced spores (ascospores), usually four or eight in number, are formed." [GOC:pamgo_curators]
is_a: GO:0075261 ! positive regulation of spore-bearing organ development
is_a: GO:0075318 ! regulation of ascus development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0075317 ! ascus development
relationship: positively_regulates GO:0075317 ! ascus development

[Term]
id: GO:0075320
name: negative regulation of ascus development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ascus development, a saclike structure produced by fungi of the phylum Ascomycota (sac fungi) in which sexually produced spores (ascospores), usually four or eight in number, are formed." [GOC:pamgo_curators]
is_a: GO:0075262 ! negative regulation of spore-bearing organ development
is_a: GO:0075318 ! regulation of ascus development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0075317 ! ascus development
relationship: negatively_regulates GO:0075317 ! ascus development

[Term]
id: GO:0075321
name: oomycete sporangium development
namespace: biological_process
def: "The process that leads to the development of an oomycete sporangium, a single-celled or many-celled structure that germinates directly to form an infection hypha or differentiates, through specialized cleavage vesicles, into between 10 and 30 zoospores, which are laterally flagellated." [GOC:pamgo_curators]
is_a: GO:0030436 ! asexual sporulation
is_a: GO:0043582 ! sporangium development
is_a: GO:0044702 ! single organism reproductive process

[Term]
id: GO:0075322
name: regulation of oomycete sporangium development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of oomycete sporangium development, a process that leads to the formation of oomycete sporangium, a single-celled or many-celled structure that germinates directly to form an infection hypha or differentiate, through specialized cleavage vesicles, into between 10 and 30 zoospores, which is laterally flagellated." [GOC:pamgo_curators]
is_a: GO:0034305 ! regulation of asexual sporulation
is_a: GO:0075310 ! regulation of sporangium development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0075321 ! oomycete sporangium development
relationship: regulates GO:0075321 ! oomycete sporangium development

[Term]
id: GO:0075323
name: positive regulation of oomycete sporangium development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of oomycete sporangium development, a process that leads to the formation of oomycete sporangium, a single-celled or many-celled structure that germinates directly to form an infection hypha or differentiate, through specialized cleavage vesicles, into between 10 and 30 zoospores, which is laterally flagellated." [GOC:pamgo_curators]
is_a: GO:0043938 ! positive regulation of sporulation
is_a: GO:0075311 ! positive regulation of sporangium development
is_a: GO:0075322 ! regulation of oomycete sporangium development
is_a: GO:1903666 ! positive regulation of asexual reproduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0075321 ! oomycete sporangium development
relationship: positively_regulates GO:0075321 ! oomycete sporangium development

[Term]
id: GO:0075324
name: negative regulation of oomycete sporangium development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of oomycete sporangium development, a process that leads to the formation of oomycete sporangium, a single-celled or many-celled structure that germinates directly to form an infection hypha or differentiate, through specialized cleavage vesicles, into between 10 and 30 zoospores, which is laterally flagellated." [GOC:pamgo_curators]
is_a: GO:0043939 ! negative regulation of sporulation
is_a: GO:0075312 ! negative regulation of sporangium development
is_a: GO:0075322 ! regulation of oomycete sporangium development
is_a: GO:1903665 ! negative regulation of asexual reproduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0075321 ! oomycete sporangium development
relationship: negatively_regulates GO:0075321 ! oomycete sporangium development

[Term]
id: GO:0075325
name: spore dispersal on or near host
namespace: biological_process
def: "Any process in which a symbiont disseminates its spores, on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "spore dispersal on or near host during symbiotic interaction" EXACT []
is_a: GO:0051701 ! interaction with host

[Term]
id: GO:0075326
name: active spore dispersal on or near host
namespace: biological_process
def: "Any active process in which a symbiont disseminates its spores, on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "active spore dispersal on or near host during symbiotic interaction" EXACT []
is_a: GO:0075325 ! spore dispersal on or near host

[Term]
id: GO:0075327
name: passive spore dispersal on or near host
namespace: biological_process
def: "Any passive process in which a symbiont disseminates its spores, on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "passive spore dispersal on or near host during symbiotic interaction" EXACT []
is_a: GO:0075325 ! spore dispersal on or near host

[Term]
id: GO:0075328
name: formation by symbiont of arbuscule for nutrient acquisition from host
namespace: biological_process
def: "The assembly by an organism of an arbuscule, a fine, tree-like hyphal structure projected into the host cell for the purpose of obtaining nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0052093 ! formation of specialized structure for nutrient acquisition from host

[Term]
id: GO:0075329
name: regulation of arbuscule formation for nutrient acquisition from host
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of symbiont arbuscule formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0044145 ! modulation of development of symbiont involved in interaction with host
is_a: GO:0060259 ! regulation of feeding behavior
relationship: regulates GO:0075328 ! formation by symbiont of arbuscule for nutrient acquisition from host

[Term]
id: GO:0075330
name: positive regulation of arbuscule formation for nutrient acquisition from host
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of symbiont arbuscule formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0044149 ! positive regulation of development of symbiont involved in interaction with host
is_a: GO:0075329 ! regulation of arbuscule formation for nutrient acquisition from host
is_a: GO:2000253 ! positive regulation of feeding behavior
relationship: positively_regulates GO:0075328 ! formation by symbiont of arbuscule for nutrient acquisition from host

[Term]
id: GO:0075331
name: negative regulation of arbuscule formation for nutrient acquisition from host
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont arbuscule formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0044147 ! negative regulation of development of symbiont involved in interaction with host
is_a: GO:0075329 ! regulation of arbuscule formation for nutrient acquisition from host
is_a: GO:2000252 ! negative regulation of feeding behavior
relationship: negatively_regulates GO:0075328 ! formation by symbiont of arbuscule for nutrient acquisition from host

[Term]
id: GO:0075332
name: modulation by host of symbiont adenylate cyclase-mediated signal transduction
namespace: biological_process
def: "Any process in which the host organism modulates the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "modulation by symbiont of host adenylate cyclase-mediated signal transduction; GO:0075335".
is_a: GO:0052470 ! modulation by host of symbiont signal transduction pathway

[Term]
id: GO:0075333
name: positive regulation by host of symbiont adenylate cyclase-mediated signal transduction
namespace: biological_process
def: "Any process in which the host organism activates, maintains or increases the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the symbiont organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "positive regulation by symbiont of host adenylate cyclase-mediated signal transduction; GO:0075336".
is_a: GO:0052525 ! positive regulation by host of symbiont signal transduction pathway
is_a: GO:0075332 ! modulation by host of symbiont adenylate cyclase-mediated signal transduction

[Term]
id: GO:0075334
name: modulation of symbiont adenylate cyclase-mediated signal transduction in response to host
namespace: biological_process
def: "Any process in which the symbiont organism modulates the frequency, rate or extent of its adenylate cyclase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
is_a: GO:0075147 ! regulation of signal transduction in response to host

[Term]
id: GO:0075335
name: positive regulation of symbiont adenylate cyclase-mediated signal transduction in response to host
namespace: biological_process
def: "Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its adenylate cyclase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
is_a: GO:0075148 ! positive regulation of signal transduction in response to host
is_a: GO:0075334 ! modulation of symbiont adenylate cyclase-mediated signal transduction in response to host

[Term]
id: GO:0075336
name: negative regulation of symbiont adenylate cyclase-mediated signal transduction in response to host
namespace: biological_process
def: "Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont adenylate cyclase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
is_a: GO:0075149 ! negative regulation of signal transduction in response to host
is_a: GO:0075334 ! modulation of symbiont adenylate cyclase-mediated signal transduction in response to host

[Term]
id: GO:0075337
name: obsolete positive regulation of growth or development of symbiont on or near host surface
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the symbiont's increase in size or mass, or its progression from an initial condition to a later condition, on or near the cells or tissues of the host organism." [GOC:pamgo_curators]
comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'positive regulation of development of symbiont on or near host surface ; GO:0044143' and 'positive regulation of growth of symbiont on or near host surface ; GO:0044142'.
synonym: "positive regulation of growth or development of symbiont on or near host surface" EXACT []
is_obsolete: true
consider: GO:0044142
consider: GO:0044143

[Term]
id: GO:0075338
name: obsolete modulation of growth or development of symbiont during interaction with host
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism." [GOC:jl]
comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'modulation of development of symbiont during interaction with host ; GO:0044145' and 'modulation of growth of symbiont during interaction with host ; GO:0044144'.
synonym: "modulation of growth or development of symbiont during interaction with host" EXACT []
is_obsolete: true
consider: GO:0044144
consider: GO:0044145

[Term]
id: GO:0075339
name: obsolete positive regulation of growth or development of symbiont during interaction with host
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism." [GOC:jl]
comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'positive regulation of development of symbiont during interaction with host ; GO:0044149' and 'positive regulation of growth of symbiont during interaction with host ; GO:0044148'.
synonym: "positive regulation of growth or development of symbiont during interaction with host" EXACT []
is_obsolete: true

[Term]
id: GO:0075340
name: obsolete negative regulation of growth or development of symbiont during interaction with host
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism." [GOC:jl]
comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'negative regulation of development of symbiont during interaction with host ; GO:0044147' and 'negative regulation of growth of symbiont during interaction with host ; GO:0044146'.
synonym: "negative regulation of growth or development of symbiont during interaction with host" EXACT []
is_obsolete: true
consider: GO:0044146
consider: GO:0044147

[Term]
id: GO:0075341
name: host cell PML body
namespace: cellular_component
def: "A nuclear body that reacts against SP100 auto-antibodies (PML = promyelocytic leukemia) located within a cell of a host organism." [GOC:BHF, GOC:jl]
synonym: "host cell PML NB" EXACT []
synonym: "host cell PML nuclear body" EXACT []
is_a: GO:0044094 ! host cell nuclear part

[Term]
id: GO:0075342
name: disruption by symbiont of host cell PML body
namespace: biological_process
def: "The breakdown, by the symbiont, of a PML body within a host cell. A PML body is a nuclear body that reacts against SP100 auto-antibodies (PML = promyelocytic leukemia). The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:BHF, GOC:jl]
synonym: "catabolism by symbiont of host cell PML body" EXACT []
synonym: "degradation by symbiont of host cell PML body" EXACT []
synonym: "disassembly by symbiont of host cell PML body" EXACT []
synonym: "disassembly by symbiont of host cell PML body during symbiotic interaction" EXACT []
synonym: "disassembly by symbiont of host cell PML NB" EXACT []
synonym: "disassembly by symbiont of host cell PML nuclear body" EXACT []
is_a: GO:0052008 ! disruption by symbiont of host cellular component

[Term]
id: GO:0075343
name: modulation by symbiont of abscisic acid levels in host
namespace: biological_process
def: "The alteration by an organism of the levels of abscisic acid in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is intended for use in annotation of symbiont gene products. For host gene products that regulate abscisic acid levels in the host, consider annotating to 'regulation of abscisic acid mediated signaling ; GO:0009787' or 'regulation of abscisic acid biosynthetic process ; GO:0010115'.
is_a: GO:0052019 ! modulation by symbiont of host hormone or growth regulator levels

[Term]
id: GO:0075344
name: modulation by symbiont of host protein levels
namespace: biological_process
def: "The alteration by an organism of protein levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is intended for use in annotation of symbiont gene products.
is_a: GO:0051817 ! modification of morphology or physiology of other organism involved in symbiotic interaction

[Term]
id: GO:0075345
name: modification by symbiont of host protein
namespace: biological_process
def: "The covalent alteration by an organism of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is intended for use in annotation of symbiont gene products. For host gene products that modify host proteins, consider annotation to 'protein modification process' GO:0006464.
subset: gosubset_prok
is_a: GO:0052228 ! metabolism by symbiont of host protein

[Term]
id: GO:0075346
name: modification by symbiont of host protein by ubiquitination
namespace: biological_process
def: "The process in which an organism adds one or more ubiquitin groups to a protein of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is intended for use in annotation of symbiont gene products. For host gene products that ubiquitinate host proteins, consider annotation to 'protein ubiquitination ; GO:0016567'.
synonym: "modification by symbiont of host protein by ubiquitinylation" EXACT []
synonym: "modification by symbiont of host protein by ubiquitylation" EXACT []
is_a: GO:0075345 ! modification by symbiont of host protein

[Term]
id: GO:0075502
name: endosome membrane permeabilization involved in viral entry into host cell
namespace: biological_process
alt_id: GO:0075518
def: "Induction of endosome membrane permeabilization triggered by an interaction between the host membrane and a membrane-penetration protein associated with the capsid. Occurs after internalization of the virus through the endosomal pathway, and results in delivery of the virus contents into the host cell cytoplasm." [GOC:bf, GOC:jl]
subset: virus_checked
synonym: "viral entry into host cell via caveolae-mediated endocytosis followed by endosome membrane" RELATED [GOC:bf, GOC:jl]
synonym: "viral entry into host cell via clathrin-mediated endocytosis followed by endosome membrane permeabilization" RELATED [GOC:bf, GOC:jl]
is_a: GO:0039665 ! permeabilization of host organelle membrane involved in viral entry into host cell
created_by: jane
creation_date: 2010-06-02T02:40:25Z

[Term]
id: GO:0075503
name: fusion of virus membrane with host macropinosome membrane
namespace: biological_process
def: "Fusion of a viral membrane with a host macropinosome membrane, that occurs after internalization of the virus through the endosomal pathway, and results in release of the viral contents into the host cell cytoplasm." [GOC:bf, GOC:jl]
subset: virus_checked
synonym: "viral entry into host cell via macropinocytosis followed by membrane fusion with the endosome membrane" EXACT []
synonym: "viral entry into host cell via macropinocytosis followed by membrane fusion with the host macropinosome membrane" RELATED [GOC:bf, GOC:jl]
is_a: GO:0039654 ! fusion of virus membrane with host endosome membrane
created_by: jane
creation_date: 2010-06-02T02:45:47Z

[Term]
id: GO:0075504
name: macropinosomal membrane permeabilization involved in viral entry into host cell
namespace: biological_process
def: "Induction of macropinosome membrane permeabilization triggered by an interaction between the host membrane and a membrane-penetration protein associated with the capsid. Occurs after internalization of the virus in a macropinosome, and results in release of the viral contents from the macropinosome into the host cell cytoplasm." [GOC:bf, GOC:jl]
subset: virus_checked
synonym: "viral entry into host cell via macropinocytosis followed by macropinosomal membrane permeabilization" RELATED [GOC:bf, GOC:jl]
is_a: GO:0039665 ! permeabilization of host organelle membrane involved in viral entry into host cell
created_by: jane
creation_date: 2010-06-02T02:48:36Z

[Term]
id: GO:0075505
name: entry of intact viral capsid into host nucleus through nuclear pore complex
namespace: biological_process
def: "Viral penetration into the host nucleus where a viral capsid passes intact through the host nuclear pore complex (NPC)." [PMID:22929056, VZ:989]
comment: This mechanism is used by viruses with capsids small enough to cross the nuclear pore complex, such as the single-stranded (ss) DNA viruses Parvoviridae, Circoviridae and Geminiviridae.
subset: virus_checked
is_a: GO:0075732 ! viral penetration into host nucleus
created_by: janelomax
creation_date: 2011-07-26T04:35:03Z

[Term]
id: GO:0075506
name: entry of viral genome into host nucleus through nuclear pore complex via importin
namespace: biological_process
def: "Viral penetration into the host nucleus where the viral genome passes through the nuclear pore complex (NPC) using the cellular importin transport machinery." [PMID:22929056, VZ:989]
comment: This mechanism is used by some RNA viruses (e.g. Orthomyxoviridae), some dsDNA viruses (e.g. Polyomaviridae) and some ssRNA viruses (e.g. Lentivirus).
subset: virus_checked
synonym: "entry of viral genome into host nucleus via cellular importin transport through the nuclear pore complex" EXACT [GOC:jl]
is_a: GO:0075732 ! viral penetration into host nucleus
created_by: janelomax
creation_date: 2011-07-26T04:36:46Z

[Term]
id: GO:0075507
name: entry of viral genome into host nucleus via docking of viral capsid to the nuclear pore complex and injection of viral genome
namespace: biological_process
def: "Viral penetration into the host nucleus where the where a viral capsid docks on the cytoplasmic side of the nuclear pore complex (NPC) and ejects the viral genome through the pore into the nucleoplasm." [PMID:22929056, VZ:989]
comment: This mechanism is used by viruses such as Herpesvirales whose capsid is too large to enter the nuclear pore complex (NPC) pore.
subset: virus_checked
is_a: GO:0075732 ! viral penetration into host nucleus
created_by: janelomax
creation_date: 2011-07-26T04:52:51Z

[Term]
id: GO:0075508
name: entry of viral genome into host nucleus via retainment of capsid in nuclear pore complex and release of genome into nucleoplasm
namespace: biological_process
def: "Viral penetration into the host nucleus where a viral capsid enters the host nuclear pore complex (NPC) but remains attached to the pore on the nuclear side. The capsid then disassembles, releasing the viral genome into the nucleoplasm." [PMID:22929056, VZ:989]
comment: This mechanism is used by viruses such as Hepadnaviridae whose capsids enter the NPC but are too big to pass intact into the nucleus.
subset: virus_checked
synonym: "entry of viral genome into host nucleus via attachment of capsid to nuclear pore complex and release of genome into nucleoplasm" EXACT [GOC:jl]
is_a: GO:0075732 ! viral penetration into host nucleus
created_by: janelomax
creation_date: 2011-07-26T04:56:10Z

[Term]
id: GO:0075509
name: endocytosis involved in viral entry into host cell
namespace: biological_process
def: "Any endocytosis that is involved in the uptake of a virus into a host cell." [GOC:bf, GOC:jl, VZ:977]
subset: goslim_virus
subset: virus_checked
synonym: "viral entry into host cell via endocytosis" RELATED [GOC:bf, GOC:jl]
synonym: "viral penetration via endocytosis followed by endosome disruption" EXACT []
synonym: "virus endocytosis by host" EXACT [UniProtKB-KW:KW-1164]
xref: VZ:977 "Virus endocytosis by host"
is_a: GO:0006897 ! endocytosis
is_a: GO:0046794 ! transport of virus
intersection_of: GO:0006897 ! endocytosis
intersection_of: part_of GO:0046718 ! viral entry into host cell
relationship: part_of GO:0046718 ! viral entry into host cell
created_by: janelomax
creation_date: 2011-07-27T11:06:34Z

[Term]
id: GO:0075510
name: macropinocytosis involved in viral entry into host cell
namespace: biological_process
def: "Any macropinocytosis that is involved in the uptake of a virus into a host cell." [GOC:jl, GOC:sp, PMID:17077125, PMID:19404330, VZ:800]
subset: virus_checked
synonym: "viral entry into host cell via macropinocytosis" RELATED [GOC:bf, GOC:jl]
xref: VZ:800 "Macropinocytosis of virus by host"
is_a: GO:0075509 ! endocytosis involved in viral entry into host cell
is_a: GO:1902539 ! multi-organism macropinocytosis
intersection_of: GO:1902539 ! multi-organism macropinocytosis
intersection_of: part_of GO:0046718 ! viral entry into host cell
relationship: part_of GO:0046718 ! viral entry into host cell
created_by: janelomax
creation_date: 2011-07-27T11:24:59Z

[Term]
id: GO:0075511
name: macropinosome lysis involved in viral entry into host cell
namespace: biological_process
def: "Viral-induced lysis of the macropinosome involved in the uptake of a virus into a host cell. Occurs after internalization of the virus in a macropinosome, and results in the release of viral contents from the macropinosome into the host cell cytoplasm." [GOC:bf, GOC:jl]
subset: virus_checked
is_a: GO:0039664 ! lysis of host organelle involved in viral entry into host cell
created_by: janelomax
creation_date: 2011-07-27T11:38:07Z

[Term]
id: GO:0075512
name: clathrin-mediated endocytosis of virus by host cell
namespace: biological_process
alt_id: GO:0075516
def: "Any clathrin-mediated endocytosis that is involved in the uptake of a virus into a host cell. Begins by invagination of a specific region of the host cell plasma membrane around the bound virus to form a clathrin-coated pit, which then pinches off to form a clathrin-coated endocytic vesicle containing the virus." [GOC:bf, GOC:jl, VZ:957]
subset: virus_checked
synonym: "viral entry into host cell via clathrin-mediated endocytosis" RELATED [GOC:bf, GOC:jl]
synonym: "viral entry into host cell via clathrin-mediated endocytosis followed by endosome lysis" NARROW []
synonym: "viral penetration via clathrin-mediated endocytosis" EXACT [GOC:sp]
xref: VZ:957 "Clathrin-mediated endocytosis of virus by host"
is_a: GO:0019065 ! receptor-mediated endocytosis of virus by host cell
is_a: GO:0072583 ! clathrin-mediated endocytosis
intersection_of: GO:0072583 ! clathrin-mediated endocytosis
intersection_of: part_of GO:0046718 ! viral entry into host cell
relationship: part_of GO:0046718 ! viral entry into host cell
created_by: janelomax
creation_date: 2011-07-27T02:08:54Z

[Term]
id: GO:0075513
name: caveolin-mediated endocytosis of virus by host cell
namespace: biological_process
def: "Any caveolin-mediated endocytosis that is involved in the uptake of a virus into a host cell. Begins when material is taken up into plasma membrane caveolae - specialized lipid rafts that form 50-70 nm flask-shaped invaginations of the plasma membrane - which then pinch off to form endocytic caveolar carriers containing the virus." [GOC:bf, GOC:jl, VZ:976]
subset: virus_checked
synonym: "viral entry into host cell via caveolae-mediated endocytosis" EXACT [GOC:bf, GOC:jl]
synonym: "viral entry into host cell via caveolin-mediated endocytosis" RELATED [GOC:bf, GOC:jl]
synonym: "viral penetration via caveolae-mediated endocytosis followed by endosome disruption" EXACT []
xref: VZ:976 "Caveolin-mediated endocytosis of virus by host"
is_a: GO:0019065 ! receptor-mediated endocytosis of virus by host cell
is_a: GO:0072584 ! caveolin-mediated endocytosis
intersection_of: GO:0072584 ! caveolin-mediated endocytosis
intersection_of: part_of GO:0046718 ! viral entry into host cell
relationship: part_of GO:0046718 ! viral entry into host cell
created_by: janelomax
creation_date: 2011-07-27T02:40:04Z

[Term]
id: GO:0075514
name: endosome lysis involved in viral entry into host cell
namespace: biological_process
def: "Viral-induced lysis of the endosome involved in uptake of a virus into a host cell. Occurs after internalization of the virus through the endosomal pathway, and results in release of the viral contents from the endosome into the host cell cytoplasm." [GOC:bf, GOC:jl]
subset: virus_checked
synonym: "viral entry into host cell via caveolae-mediated endocytosis followed by endosome lysis" EXACT [GOC:bf, GOC:jl]
is_a: GO:0039664 ! lysis of host organelle involved in viral entry into host cell
created_by: janelomax
creation_date: 2011-07-27T02:56:15Z

[Term]
id: GO:0075515
name: obsolete viral entry into host cell via caveolin-mediated endocytosis followed by genetic injection through the endosome membrane
namespace: biological_process
def: "OBSOLETE. The uptake of a virus into a host cell that begins when material is taken up into plasma membrane caveolae which then pinch off to form endocytic caveolar carriers containing the virus. The caveolar carriers then deliver their viral content to early endosomes, and the process ends when viral nucleic acid is released into the host cytoplasm by its injection through the endosome membrane." [GOC:jl, VZ:976]
comment: This term was made obsolete because it doesn't represent a genuine process. The term injection is mostly used for prokaryotic viruses where there is no endocytosis.
subset: virus_checked
synonym: "viral entry into host cell via caveolae-mediated endocytosis followed by genetic injection through the endosome membrane" EXACT [GOC:bf, GOC:jl]
synonym: "viral entry into host cell via caveolin-mediated endocytosis followed by genetic injection through the endosome membrane" EXACT []
is_obsolete: true
created_by: janelomax
creation_date: 2011-07-27T02:57:55Z

[Term]
id: GO:0075519
name: microtubule-dependent intracellular transport of viral material
namespace: biological_process
def: "The directed movement of the viral genome or viral particle within the host cell cytoplasm along host microtubules. Microtubule-dependent transport involves motor proteins like dynein and kinesin and is mostly used by viruses that target their genomes to the nucleus." [VZ:983]
subset: virus_checked
is_a: GO:0075733 ! intracellular transport of virus
created_by: janelomax
creation_date: 2011-08-03T01:45:25Z

[Term]
id: GO:0075520
name: actin-dependent intracellular transport of virus
namespace: biological_process
def: "The directed movement of a virus, or part of a virus, within the host cell cytoplasm via the host's actin filaments. Actin-dependent transport is induced by viral proteins that interact with actin and/or host cell motor proteins like myosins or that promotes actin polymerization/depolymerization reactions." [UniProtKB-KW:KW-1178, VZ:991]
subset: virus_checked
synonym: "actin-dependent intracellular transport of viral material" EXACT []
xref: VZ:991 "Actin-dependent inwards viral transport"
is_a: GO:0075733 ! intracellular transport of virus
created_by: janelomax
creation_date: 2011-08-03T01:45:55Z

[Term]
id: GO:0075521
name: microtubule-dependent intracellular transport of viral material towards nucleus
namespace: biological_process
def: "The directed movement of a virus, or part of a virus, towards the host cell nucleus using host microtubules." [UniProtKB-KW:KW-1177, VZ:983]
subset: virus_checked
synonym: "microtubule-dependent intracellular transport of viral material to nucleus" EXACT [GOC:jl]
xref: VZ:983 "Microtubular inwards viral transport"
is_a: GO:0051169 ! nuclear transport
is_a: GO:0075519 ! microtubule-dependent intracellular transport of viral material
is_a: GO:0075606 ! transport of viral material towards nucleus
created_by: janelomax
creation_date: 2011-08-03T02:09:21Z

[Term]
id: GO:0075522
name: IRES-dependent viral translational initiation
namespace: biological_process
def: "Process by which viral mRNA translation is initiated, where a domain in the 5' untranslated region (UTR) of the viral mRNA called an internal ribosome entry site (IRES) binds the host 43S preinitiation complex, circumventing regular cap-dependent translation initiation." [GOC:bf, GOC:jl, PMID:19632368, VZ:867]
subset: virus_checked
xref: VZ:867 "Viral initiation of translation: IRES and DLP"
is_a: GO:0002192 ! IRES-dependent translational initiation
is_a: GO:0016032 ! viral process
is_a: GO:0044033 ! multi-organism metabolic process
relationship: part_of GO:0019081 ! viral translation
created_by: janelomax
creation_date: 2011-08-03T02:25:03Z

[Term]
id: GO:0075523
name: viral translational frameshifting
namespace: biological_process
def: "A process which occurs during viral translation, which involves a translational recoding mechanism called programmed ribosomal frameshifting. This causes the ribosome to alter its reading of the mRNA to an a different open reading frame to produce alternate viral proteins." [GOC:bf, GOC:ch, GOC:jl, PMID:24825891, PMID:8852897, VZ:860]
comment: This term is intended to annotate gene products involved in the process of viral translational frameshifting, not viral proteins produced by this translation process.
subset: virus_checked
synonym: "ribosomal frameshifting involved in viral translation" EXACT [GOC:jl]
xref: VZ:860 "Ribosomal frameshifting"
is_a: GO:0006452 ! translational frameshifting
is_a: GO:0016032 ! viral process
is_a: GO:0044034 ! multi-organism biosynthetic process
relationship: part_of GO:0019081 ! viral translation
created_by: janelomax
creation_date: 2011-08-03T02:48:46Z

[Term]
id: GO:0075524
name: ribosomal skipping
namespace: biological_process
def: "A translation process in which a specific viral peptide prevents the ribosome from covalently linking a new inserted amino acid, and lets it continue translation, thereby cleaving the nascent protein while allowing translation to continue." [GOC:bf, GOC:ch, GOC:jl, VZ:914]
comment: This term is intended to annotate gene products involved in the process of ribosomal skipping, not viral proteins produced by this translation process.
subset: virus_checked
xref: VZ:914 "Ribosomal skipping"
is_a: GO:0016032 ! viral process
relationship: part_of GO:0019081 ! viral translation
created_by: janelomax
creation_date: 2011-08-03T03:19:37Z

[Term]
id: GO:0075525
name: viral translational termination-reinitiation
namespace: biological_process
def: "A process which occurs as part of viral mRNA translation which allows expression of a downstream open reading frame (ORF) in a dicistronic mRNA. In this process, ribosomes translate the upstream ORF but following termination, a proportion of 40S subunits remain tethered to the mRNA and go on to re-initiate translation at the start codon of the downstream ORF." [GOC:bf, GOC:ch, GOC:jl, PMID:18631147, PMID:18824510, VZ:858]
comment: This term is intended to annotate gene products involved in the process of viral translational termination-reinitiation, not viral proteins produced by this translation process.
subset: virus_checked
synonym: "termination reinitiation involved in viral translation" EXACT [GO:jl]
synonym: "viral translation involving termination re-initiation" EXACT [GO:jl]
synonym: "viral translation involving termination-reinitiation" EXACT [GO:jl]
synonym: "viral translation involving translational stop-start" EXACT [GO:jl]
xref: VZ:858 "RNA termination-reinitiation"
is_a: GO:0016032 ! viral process
relationship: part_of GO:0019081 ! viral translation
created_by: janelomax
creation_date: 2011-08-04T12:01:22Z

[Term]
id: GO:0075526
name: cap snatching
namespace: biological_process
def: "A transcription initiation process during which a nucleotide sequence between 10 and 20 nucleotides in size is cleaved from the 5' end of host mRNAs by a viral RNA-dependent polymerase. The capped leader sequence obtained is subsequently used to prime transcription on the viral genome, which ultimately leads to the synthesis of capped, translatable viral mRNAs." [GOC:bf, GOC:jl, VZ:839]
subset: virus_checked
synonym: "cap snatching involved in viral mRNA transcription" EXACT [GO:jl]
xref: VZ:839
is_a: GO:0016032 ! viral process
relationship: part_of GO:0039697 ! negative stranded viral RNA transcription
created_by: janelomax
creation_date: 2011-08-04T01:19:00Z

[Term]
id: GO:0075527
name: viral RNA editing
namespace: biological_process
def: "The process by which bases in viral mRNA are chemically altered during viral transcription. This is usually the incorporation of 1 - 6 additional nucleotides, which shifts the reading frame, allowing the generation of different protein products or through a specific nucleotide change that eliminates the termination codon." [PMID:1629949, VZ:857]
subset: virus_checked
synonym: "RNA editing involved in viral mRNA transcription" EXACT [GO:jl]
xref: VZ:857 "RNA editing"
is_a: GO:0009451 ! RNA modification
is_a: GO:0016032 ! viral process
is_a: GO:0044033 ! multi-organism metabolic process
relationship: part_of GO:0019083 ! viral transcription
created_by: janelomax
creation_date: 2011-08-04T02:07:03Z

[Term]
id: GO:0075528
name: modulation by virus of host immune response
namespace: biological_process
def: "The process in which a virus effects a change in the host immune response." [GOC:bf, GOC:jl]
subset: goslim_virus
subset: virus_checked
synonym: "regulation by virus of host immune system process" EXACT [GOC:jl]
is_a: GO:0019054 ! modulation by virus of host process
is_a: GO:0052553 ! modulation by symbiont of host immune response
created_by: janelomax
creation_date: 2011-08-04T02:47:57Z

[Term]
id: GO:0075529
name: establishment of latency as a circular episome
namespace: biological_process
def: "A process by which a virus establishes a latent state within its host as an episome, where the viral genome remains silent in the cytoplasm or nucleus as a circular structure." [GOC:jl]
synonym: "establishment of circular plasmid latency" EXACT []
synonym: "establishment of latency as a circular plasmid" EXACT []
xref: PHI:0000054
is_a: GO:0075720 ! establishment of episomal latency
created_by: janelomax
creation_date: 2011-08-04T03:08:17Z

[Term]
id: GO:0075530
name: establishment of latency as a linear episome
namespace: biological_process
def: "A process by which a virus establishes a latent state within its host as an episome, where the viral genome remains silent in the cytoplasm or nucleus as linear structure." [GOC:jl]
synonym: "establishment of latency as a linear plasmid" EXACT []
synonym: "establishment of linear plasmid latency" EXACT []
xref: PHI:0000053
is_a: GO:0075720 ! establishment of episomal latency
created_by: janelomax
creation_date: 2011-08-04T03:14:23Z

[Term]
id: GO:0075606
name: transport of viral material towards nucleus
namespace: biological_process
def: "The directed movement of a virus, or part of a virus, towards the host cell nucleus. The process begins after viral entry, and ends when the viral material is at the nuclear membrane." [GOC:bf, GOC:jl, VZ:990]
comment: This process does not include the viral material crossing the nuclear membrane. For transport of viral material into the nucleus, consider instead: 'viral penetration into host nucleus ; GO:0075732'.
subset: goslim_virus
subset: virus_checked
synonym: "cytoplasmic inwards viral transport" EXACT [UniProtKB-KW:KW-1176, VZ:990]
synonym: "transport of viral material to nucleus" EXACT [GOC:jl]
synonym: "viral genome transport to host cell nucleus" EXACT []
xref: VZ:990 "Cytoplasmic inwards viral transport"
is_a: GO:0075733 ! intracellular transport of virus
created_by: jane
creation_date: 2009-11-05T03:33:36Z

[Term]
id: GO:0075705
name: obsolete viral entry into host cell via clathrin-mediated endocytosis followed by genetic injection through the endosome membrane
namespace: biological_process
def: "OBSOLETE. The uptake of a virus into a host cell that begins by invagination of a specific region of the host cell plasma membrane around the bound virus to form a clathrin-coated pit, which then pinches off to form a clathrin-coated endocytic vesicles containing the virus. The vesicle then delivers its viral content to early endosomes, and the process ends when the viral nucleic acid is released into the host cytoplasm by its injection through the endosome membrane." [GOC:jl]
comment: This term was made obsolete because it doesn't represent a genuine process. The term injection is mostly used for prokaryotic viruses where there is no endocytosis.
subset: virus_checked
synonym: "viral entry into host cell via clathrin-mediated endocytosis followed by genetic injection through the endosome membrane" EXACT []
synonym: "viral penetration via endocytosis followed by genetic injection through the endosome membrane" EXACT []
is_obsolete: true
created_by: jane
creation_date: 2009-04-23T02:08:06Z

[Term]
id: GO:0075713
name: establishment of integrated proviral latency
namespace: biological_process
alt_id: GO:0019047
def: "A process by which the virus integrates into the host genome and establishes as a stable provirus or prophage." [GOC:jl]
subset: goslim_virus
synonym: "prophage integration" EXACT []
synonym: "provirus integration" EXACT []
xref: PHI:0000055
xref: Reactome:REACT_6918 "Integration of provirus, Homo sapiens"
xref: Reactome:REACT_8990 "Integration of viral DNA into host genomic DNA, Human immunodeficiency virus 1"
xref: VZ:980 "Viral genome integration"
is_a: GO:0019043 ! establishment of viral latency
relationship: has_part GO:0044826 ! viral genome integration into host DNA
created_by: jane
creation_date: 2009-05-07T02:28:41Z

[Term]
id: GO:0075720
name: establishment of episomal latency
namespace: biological_process
def: "A process by which a virus establishes a latent state within its host as an episome, where the viral genome remains silent in the cytoplasm or nucleus as a distinct genetic entity." [GOC:jl]
synonym: "establishment as a plasmid prophage" NARROW []
synonym: "establishment of plasmid latency" EXACT []
xref: PHI:0000051
is_a: GO:0019043 ! establishment of viral latency
created_by: jane
creation_date: 2009-11-26T03:57:44Z

[Term]
id: GO:0075732
name: viral penetration into host nucleus
namespace: biological_process
def: "The crossing by the virus of the host nuclear membrane, either as naked viral genome or for small viruses as an intact capsid." [PMID:22929056, VZ:989]
subset: goslim_virus
subset: virus_checked
synonym: "viral entry into host nucleus" EXACT []
synonym: "viral import into host nucleus" EXACT []
xref: VZ:989 "Viral penetration into host nucleus"
is_a: GO:0075733 ! intracellular transport of virus
is_a: GO:1902594 ! multi-organism nuclear import
created_by: jane
creation_date: 2009-05-01T02:43:16Z

[Term]
id: GO:0075733
name: intracellular transport of virus
namespace: biological_process
alt_id: GO:0046788
alt_id: GO:0046795
alt_id: GO:0046796
def: "The directed movement of a virus, or part of a virus, within the host cell." [GOC:ai, GOC:bf, GOC:jl, PMID:11733033]
subset: virus_checked
synonym: "egress of virus within host cell" EXACT []
synonym: "intracellular transport of viral material" EXACT [GOC:bf, GOC:jl]
synonym: "intracellular virion transport" RELATED []
synonym: "movement of virus within host cell" EXACT []
synonym: "viral egress" RELATED []
synonym: "viral genome transport in host cell" EXACT []
xref: Reactome:REACT_115827 "Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus, Homo sapiens"
xref: Reactome:REACT_115893 "Membrane binding and targeting of GAG proteins, Homo sapiens"
xref: Reactome:REACT_6136 "vRNP Export through the nuclear pore, Homo sapiens"
xref: Reactome:REACT_6138 "Recognition of the Nuclear Localization Signal (NLS) by a Karyopherin Alpha Family Protein, Homo sapiens"
xref: Reactome:REACT_6164 "Release of the RNP into the host cell nucleus, Homo sapiens"
xref: Reactome:REACT_6179 "NEP/NS2 Interacts with the Cellular Export Machinery, Homo sapiens"
xref: Reactome:REACT_6194 "Binding of vRNP:M1:NEP complex to CRM1 export receptor, Homo sapiens"
xref: Reactome:REACT_6248 "Transport of Ribonucleoproteins into the Host Nucleus, Homo sapiens"
xref: Reactome:REACT_6289 "Docking and transport of the RNP:Karyopherin complex through the nuclear pore, Homo sapiens"
xref: Reactome:REACT_6296 "Export of Viral Ribonucleoproteins from Nucleus, Homo sapiens"
xref: Reactome:REACT_6303 "Binding of NEP/NS2 to vRNP:M1, Homo sapiens"
xref: Reactome:REACT_6322 "Recruitment of Karyopherin Beta to form a Trimeric Complex, Homo sapiens"
is_a: GO:0046794 ! transport of virus
is_a: GO:1902583 ! multi-organism intracellular transport
intersection_of: GO:0046794 ! transport of virus
intersection_of: occurs_in GO:0005622 ! intracellular
relationship: occurs_in GO:0005622 ! intracellular
relationship: part_of GO:0019058 ! viral life cycle
created_by: jane
creation_date: 2009-05-01T04:01:33Z

[Term]
id: GO:0080001
name: mucilage extrusion from seed coat
namespace: biological_process
def: "The process in which seed mucilage expands through hydration and breaks the outer cell wall that encapsulates the whole seed upon imbibition. Mucilage, mainly composed of pectins, is formed during seed development and deposited into the apoplast underneath the outer wall of the seed coat." [PMID:18266922]
synonym: "mucilage release from seed coat" RELATED []
synonym: "secretion of mucilage from seed coat" RELATED []
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0048609 ! multicellular organismal reproductive process
relationship: part_of GO:0009845 ! seed germination
relationship: part_of GO:0048316 ! seed development

[Term]
id: GO:0080002
name: UDP-glucose:4-aminobenzoate acylglucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-aminobenzoate + UDP-glucose = p-aminobenzoate-beta-D-glucopyranosyl ester + UDP." [EC:2.4.1.-, PMID:18385129]
synonym: "UDP-glucose:p-aminobenzoate acylglucosyltransferase activity" RELATED []
synonym: "UDP-glucose:p-aminobenzoate glucosyltransferase activity" RELATED []
synonym: "UDP-glucose:pABA acylglucosyltransferase activity" RELATED []
xref: MetaCyc:RXN-6142
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0080003
name: thalianol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the triterpene thalianol." [PMID:18356490]
synonym: "thalianol metabolism" EXACT [GOC:tair_curators]
is_a: GO:0010683 ! tricyclic triterpenoid metabolic process

[Term]
id: GO:0080004
name: thalian-diol desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: a thalian-diol = a desaturated thalian-diol. This reaction is the introduction of a double bond to a thalian-diol molecule at carbon 15." [PMID:18356490]
xref: EC:1.14.21.-
xref: MetaCyc:RXN-9637
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0080005
name: photosystem stoichiometry adjustment
namespace: biological_process
def: "Adjustment of Photosystem I/Photosystem II ratio in response to light conditions. The function of photosystem stoichiometry adjustment is to compensate for any deficiency in energy conversion at either photosystem I or photosystem II by increasing the quantity the photosystem that will otherwise become the rate-limiting to overall photosynthesis." [PMID:11607105]
is_a: GO:0010109 ! regulation of photosynthesis

[Term]
id: GO:0080006
name: internode patterning
namespace: biological_process
def: "Determines the spacing between two shoot nodes. A shoot node is the region of the shoot where the spikelet, flower, floret, branch, bud and/or leaves are attached." [GOC:tb]
is_a: GO:0007389 ! pattern specification process
relationship: part_of GO:0048367 ! shoot system development

[Term]
id: GO:0080007
name: S-nitrosoglutathione reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: glutathione N-hydroxysulfenamide + NADH + H+ = S-nitrosoglutathione + NAD+." [MetaCyc:RXN-10742, PMID:11260719]
xref: MetaCyc:RXN-10742
is_a: GO:0016657 ! oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor

[Term]
id: GO:0080008
name: Cul4-RING E3 ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:16792691, PMID:18223036, PMID:18552200]
is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex

[Term]
id: GO:0080009
name: mRNA methylation
namespace: biological_process
def: "The posttranscriptional addition of methyl groups to specific residues in an mRNA molecule." [PMID:18505803]
is_a: GO:0001510 ! RNA methylation
is_a: GO:0016556 ! mRNA modification

[Term]
id: GO:0080010
name: obsolete regulation of oxygen and reactive oxygen species metabolic process
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving dioxygen (O2), or any of the reactive oxygen species, e.g. superoxide anions (O2-), hydrogen peroxide (H2O2), and hydroxyl radicals (-OH)." [PMID:18450450]
comment: This term was made obsolete because, as part of the GO/ChEBI alignment effort, curators determined that oxygen and reactive oxygen species should not be grouped together.
synonym: "regulation of oxygen and reactive oxygen species metabolic process" EXACT []
is_obsolete: true
consider: GO:2000374
consider: GO:2000377

[Term]
id: GO:0080011
name: baruol synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-2,3-epoxysqualene = baruol. Baruol is also known as D:B-Friedo-Baccharan-5,21-dien-3-ol." [MetaCyc:RXN-9685, PMID:17705488]
xref: EC:5.4.99.-
xref: MetaCyc:RXN-9685
is_a: GO:0031559 ! oxidosqualene cyclase activity

[Term]
id: GO:0080012
name: trihydroxyferuloyl spermidine O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: trihydroxyferuloyl spermidine + S-adenosyl-L-methionine = dihydroxyferuloyl-sinapoyl spermidine + S-adenosyl-L-homocysteine + H+." [PMID:18557837]
synonym: "N1,N5,N10-tris-(5-hydroxyferuloyl)spermidine O-methyltransferase activity" EXACT [MetaCyc:RXN-11263]
xref: EC:2.1.1.-
xref: MetaCyc:RXN-11263
is_a: GO:0008171 ! O-methyltransferase activity

[Term]
id: GO:0080013
name: (E,E)-geranyllinalool synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: all-trans-geranyl-geranyl diphosphate + H2O = (E,E)-geranyllinalool + diphosphate." [MetaCyc:RXN-10441, PMID:18398052]
xref: MetaCyc:RXN-10441
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0080014
name: thalianol hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: a thalianol = a thalian-diol. This reaction is the addition of a hydroxyl group to thalianol ((13R,14R,17E)-podioda-8,17,21-trien-3beta-ol) to create a thalian-diol ((13R,14R,17E)-podioda-8,17,21-trien-3beta,X-diol), where the hydroxyl group may be attached at one of several different available carbons in ring B or C of thalianol, indicated by the X." [MetaCyc:RXN-9631, PMID:17474751, PMID:18356490]
comment: In Field and Osbourn 2008 (PMID:18356490), thalianol is referred to as (3S,13S,3R)-malabarica-8,17,21-trien-3-ol and thalian-diol is referred to as (3S,13S,14R)-malabarica-8,17,21-trien-3,?-diol, but the error in this naming system was pointed out in Kolesnikova 2007 (PMID:17474751). The new names used in the definition have been approved by the authors (Field and Osbourn 2008).
xref: EC:1.14.13.-
xref: MetaCyc:RXN-9631
is_a: GO:0004497 ! monooxygenase activity

[Term]
id: GO:0080015
name: sabinene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranyl diphosphate = sabinene + diphosphate." [MetaCyc:RXN-5103, PMID:12566586, PMID:9747540]
xref: EC:4.2.3.-
xref: MetaCyc:RXN-5103
is_a: GO:0009975 ! cyclase activity
is_a: GO:0010333 ! terpene synthase activity

[Term]
id: GO:0080016
name: (-)-E-beta-caryophyllene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (-)-E-beta-caryophyllene + diphosphate." [MetaCyc:RXN-8414, PMID:12566586, PMID:9442047]
xref: EC:4.2.3.-
xref: MetaCyc:RXN-8414
is_a: GO:0009975 ! cyclase activity
is_a: GO:0010334 ! sesquiterpene synthase activity

[Term]
id: GO:0080017
name: alpha-humulene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = alpha-humulene + diphosphate." [PMID:12566586, PMID:9442047]
xref: EC:4.2.3.-
xref: MetaCyc:RXN-8415
is_a: GO:0009975 ! cyclase activity
is_a: GO:0010334 ! sesquiterpene synthase activity

[Term]
id: GO:0080018
name: anthocyanin 5-O-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: an anthocyanin + UDP-D-glucose = an anthocyanin-5-O-glucoside + UDP." [PMID:15807784]
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0080019
name: fatty-acyl-CoA reductase (alcohol-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA." [PMID:16980563]
synonym: "fatty acyl CoA reductase (alcohol-forming) activity" EXACT [GOC:curators]
synonym: "fatty acyl-CoA reductase (alcohol-forming) activity" EXACT [GOC:mah]
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0080020
name: regulation of coenzyme A biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving coenzyme A." [PMID:18621975]
is_a: GO:0009118 ! regulation of nucleoside metabolic process
is_a: GO:0051196 ! regulation of coenzyme metabolic process
is_a: GO:1900371 ! regulation of purine nucleotide biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0015937 ! coenzyme A biosynthetic process
relationship: regulates GO:0015937 ! coenzyme A biosynthetic process

[Term]
id: GO:0080021
name: response to benzoic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benzoic acid stimulus." [PMID:18753285]
synonym: "response to benzoic acid stimulus" EXACT [GOC:dos]
is_a: GO:0001101 ! response to acid chemical
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0080022
name: primary root development
namespace: biological_process
def: "The process whose specific outcome is the progression of the primary root over time, from its formation to the mature structure. The primary root develops directly from the embryonic radicle." [GOC:dhl]
is_a: GO:0048364 ! root development

[Term]
id: GO:0080023
name: 3R-hydroxyacyl-CoA dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3R-hydroxyacyl-CoA = 2E-enoyl-CoA + H2O." [PMID:16982622]
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0080024
name: indolebutyric acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving indolebutyric acid, a compound that serves as an active or storage form of the hormone indole-3-acetic acid (an auxin) in many plants." [PMID:18725356]
synonym: "IBA metabolic process" EXACT []
synonym: "IBA metabolism" EXACT []
synonym: "indole-3-butyric acid metabolic process" NARROW []
is_a: GO:0009850 ! auxin metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process
is_a: GO:0042430 ! indole-containing compound metabolic process

[Term]
id: GO:0080025
name: phosphatidylinositol-3,5-bisphosphate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions." [GOC:bf, PMID:18397324]
synonym: "PtdIns(3,5)P2 binding" EXACT []
is_a: GO:1902936 ! phosphatidylinositol bisphosphate binding

[Term]
id: GO:0080026
name: response to indolebutyric acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indolebutyric acid stimulus." [PMID:18725356]
synonym: "response to IBA stimulus" EXACT []
synonym: "response to indole-3-butyric acid stimulus" NARROW []
synonym: "response to indolebutyric acid stimulus" EXACT [GOC:dos]
is_a: GO:0001101 ! response to acid chemical
is_a: GO:0009733 ! response to auxin
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0080027
name: response to herbivore
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a herbivore." [PMID:18987211]
is_a: GO:0051707 ! response to other organism

[Term]
id: GO:0080028
name: nitrile biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a nitrile, an organic compound containing trivalent nitrogen attached to one carbon atom." [PMID:18987211]
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process
is_a: GO:0050898 ! nitrile metabolic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process

[Term]
id: GO:0080029
name: cellular response to boron-containing substance levels
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of boron-containing substances." [PMID:18952773]
synonym: "cellular response to boron levels" EXACT [GOC:curators]
is_a: GO:0010036 ! response to boron-containing substance
is_a: GO:0031669 ! cellular response to nutrient levels
is_a: GO:0070887 ! cellular response to chemical stimulus

[Term]
id: GO:0080030
name: methyl indole-3-acetate esterase activity
namespace: molecular_function
def: "Catalysis of the reaction: methyl indole-3-acetate + H2O = indole-3-acetate + methanol + H+." [MetaCyc:RXN-10711, PMID:18467465]
synonym: "indole-3-Acetic acid methyl ester esterase activity" EXACT []
synonym: "MeIAA esterase activity" EXACT []
synonym: "Methyl IAA esterase activity" EXACT []
synonym: "methyl indole-3-acetate esterase activity" RELATED []
xref: EC:3.1.1.-
xref: MetaCyc:RXN-10711
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0080031
name: methyl salicylate esterase activity
namespace: molecular_function
def: "Catalysis of the reaction: methyl salicylate + H2O = salicylic acid + methanol + H+." [MetaCyc:RXNQT-4366, PMID:18467465, PMID:18643994]
synonym: "MESA esterase activity" EXACT []
synonym: "methyl SA esterase activity" EXACT []
synonym: "methylsalicylate esterase activity" EXACT []
synonym: "salicylic acid methyl ester esterase activity" EXACT []
xref: EC:3.1.1.-
xref: MetaCyc:RXNQT-4366
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0080032
name: methyl jasmonate esterase activity
namespace: molecular_function
def: "Catalysis of the reaction: a methyl jasmonate + H2O = a jasmonic acid + methanol." [PMID:15233793, PMID:18467465]
synonym: "jasmonic acid methyl ester esterase activity" EXACT []
synonym: "MEJA esterase activity" EXACT []
synonym: "methyl JA esterase activity" EXACT []
xref: EC:3.1.1.-
xref: MetaCyc:RXN-10767
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0080033
name: response to nitrite
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrate stimulus." [GOC:dhl, PMID:17951451]
is_a: GO:0001101 ! response to acid chemical
is_a: GO:0010035 ! response to inorganic substance
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound

[Term]
id: GO:0080034
name: host response to induction by symbiont of tumor, nodule or growth in host
namespace: biological_process
def: "Any process that results in a change in the state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the formation of an abnormal mass of cells in the host organism, induced by a symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:18836040]
is_a: GO:0009608 ! response to symbiont

[Term]
id: GO:0080035
name: 2-hydroxy-but-3-enyl glucosinolate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of progoitrin, a 2-hydroxy-but-3-enyl glucosinolate. Glucosinolates are substituted thioglucosides found in rapeseed products and related cruciferae, and progoitrin has been implicated in causing goiters in mammals and bitter taste in cruciferous vegetables." [PMID:11560911, PMID:18945935]
synonym: "2-hydroxy-but-3-enyl glucosinolate anabolism" EXACT []
synonym: "2-hydroxy-but-3-enyl glucosinolate biosynthesis" EXACT []
synonym: "2-hydroxy-but-3-enyl glucosinolate formation" EXACT []
synonym: "2-hydroxy-but-3-enyl glucosinolate synthesis" EXACT []
synonym: "progoitrin biosynthesis" EXACT []
synonym: "progoitrin biosynthetic process" EXACT []
synonym: "progoitrin synthesis" EXACT []
is_a: GO:0019761 ! glucosinolate biosynthetic process

[Term]
id: GO:0080036
name: regulation of cytokinin-activated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cytokinin signaling." [GOC:dhl]
synonym: "regulation of cytokinin mediated signaling pathway" RELATED []
synonym: "regulation of cytokinin mediated signalling" EXACT [GOC:mah]
is_a: GO:0009966 ! regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009736 ! cytokinin-activated signaling pathway
relationship: regulates GO:0009736 ! cytokinin-activated signaling pathway

[Term]
id: GO:0080037
name: negative regulation of cytokinin-activated signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cytokinin signaling." [GOC:dhl, PMID:14973166]
synonym: "negative regulation of cytokinin mediated signaling pathway" RELATED []
synonym: "negative regulation of cytokinin mediated signalling" EXACT [GOC:mah]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0080036 ! regulation of cytokinin-activated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009736 ! cytokinin-activated signaling pathway
relationship: negatively_regulates GO:0009736 ! cytokinin-activated signaling pathway

[Term]
id: GO:0080038
name: positive regulation of cytokinin-activated signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cytokinin signaling." [GOC:dhl]
synonym: "positive regulation of cytokinin mediated signaling pathway" RELATED []
synonym: "positive regulation of cytokinin mediated signalling" EXACT [GOC:mah]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0080036 ! regulation of cytokinin-activated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009736 ! cytokinin-activated signaling pathway
relationship: positively_regulates GO:0009736 ! cytokinin-activated signaling pathway

[Term]
id: GO:0080039
name: xyloglucan endotransglucosylase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a beta-(1,4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of a xyloglucan or an oligosaccharide of xyloglucan." [EC:2.4.1.207, GOC:ask, PMID:1400418, PMID:1554366]
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0080040
name: positive regulation of cellular response to phosphate starvation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellular response to phosphate starvation." [PMID:18315545]
is_a: GO:0010647 ! positive regulation of cell communication
is_a: GO:0032109 ! positive regulation of response to nutrient levels
is_a: GO:0080135 ! regulation of cellular response to stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016036 ! cellular response to phosphate starvation
relationship: positively_regulates GO:0016036 ! cellular response to phosphate starvation

[Term]
id: GO:0080041
name: ADP-ribose pyrophosphohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: ADP-ribose + H2O = AMP + ribose-1-phosphate." [GOC:tb]
is_a: GO:0019144 ! ADP-sugar diphosphatase activity

[Term]
id: GO:0080042
name: ADP-glucose pyrophosphohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: ADP-glucose + H2O = AMP + glucose-1-phosphate." [GOC:tb]
is_a: GO:0019144 ! ADP-sugar diphosphatase activity

[Term]
id: GO:0080043
name: quercetin 3-O-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a glucosyl group from UDP-glucose to the 3-hydroxy group of a quercetin molecule." [PMID:15352060]
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0080044
name: quercetin 7-O-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a glucosyl group from UDP-glucose to the 7-hydroxy group of a quercetin molecule." [PMID:15352060]
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0080045
name: quercetin 3'-O-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a glucosyl group from UDP-glucose to the 3'-hydroxy group of a quercetin molecule." [PMID:15352060]
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0080046
name: quercetin 4'-O-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a glucosyl group from UDP-glucose to the 4'-hydroxy group of a quercetin molecule." [PMID:15352060]
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0080047
name: GDP-L-galactose phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-L-galactose + phosphate = L-galactose-1-P + GDP." [EC:2.7.7.69, PMID:18463094]
xref: EC:2.7.7.69
xref: MetaCyc:RXNQT-4141
is_a: GO:0004645 ! phosphorylase activity

[Term]
id: GO:0080048
name: GDP-D-glucose phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-D-glucose + phosphate = D-glucose-1-P + GDP." [PMID:18463094]
is_a: GO:0004645 ! phosphorylase activity

[Term]
id: GO:0080049
name: L-gulono-1,4-lactone dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-gulono-1,4-lactone + 2 ferricytochrome c = L-ascorbate + 2 ferrocytochrome c." [PMID:18190525]
is_a: GO:0016632 ! oxidoreductase activity, acting on the CH-CH group of donors, cytochrome as acceptor

[Term]
id: GO:0080050
name: regulation of seed development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of seed development." [PMID:19141706]
is_a: GO:0048580 ! regulation of post-embryonic development
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048316 ! seed development
relationship: regulates GO:0048316 ! seed development

[Term]
id: GO:0080051
name: cutin transport
namespace: biological_process
def: "The directed movement of cutin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Cutin, which consists of C16-18 fatty acids, is the major component of the cuticle that covers the plant surface." [PMID:17951461]
is_a: GO:0044765 ! single-organism transport
is_a: GO:0071702 ! organic substance transport

[Term]
id: GO:0080052
name: response to histidine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histidine stimulus." [PMID:15889294]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0043200 ! response to amino acid

[Term]
id: GO:0080053
name: response to phenylalanine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phenylalanine stimulus." [PMID:15889294]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0043200 ! response to amino acid

[Term]
id: GO:0080054
name: low-affinity nitrate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of nitrate ions (NO3-) from one side of a membrane to the other. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [PMID:19050168]
synonym: "low affinity nitrate transmembrane transporter activity" EXACT []
is_a: GO:0015112 ! nitrate transmembrane transporter activity

[Term]
id: GO:0080055
name: low-affinity nitrate transport
namespace: biological_process
def: "The directed movement of nitrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [PMID:19050168]
synonym: "low affinity nitrate transport" EXACT []
is_a: GO:0015706 ! nitrate transport

[Term]
id: GO:0080056
name: petal vascular tissue pattern formation
namespace: biological_process
def: "Vascular tissue pattern formation as it occurs in the petal of vascular plants." [PMID:17369435]
is_a: GO:0010051 ! xylem and phloem pattern formation
created_by: donghui
creation_date: 2009-04-13T02:25:01Z

[Term]
id: GO:0080057
name: sepal vascular tissue pattern formation
namespace: biological_process
def: "Vascular tissue pattern formation as it occurs in the sepal of vascular plants." [PMID:17369435]
is_a: GO:0010051 ! xylem and phloem pattern formation
created_by: donghui
creation_date: 2009-04-13T02:26:19Z

[Term]
id: GO:0080058
name: protein deglutathionylation
namespace: biological_process
def: "The protein modification process in which a glutathione molecule is removed from a protein amino acid by breaking a disulfide linkage." [GOC:tb]
synonym: "protein amino acid deglutathionylation" EXACT [GOC:bf]
is_a: GO:0006464 ! cellular protein modification process
created_by: donghui
creation_date: 2009-04-13T02:48:06Z

[Term]
id: GO:0080059
name: flavonol 3-O-arabinosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-arabinose + a flavonol = UDP + a flavonol 3-O-D-arabinoside." [PMID:18757557]
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0052636 ! arabinosyltransferase activity
created_by: donghui
creation_date: 2009-04-13T02:55:11Z

[Term]
id: GO:0080060
name: integument development
namespace: biological_process
def: "The process whose specific outcome is the progression of the integument over time, from its formation to the mature structure. Integument is one of the layers of tissue that usually covers the ovule, enveloping the nucellus and forming the micropyle at the apex." [PMID:19054366, PO:0020021]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0009888 ! tissue development
relationship: part_of GO:0048481 ! plant ovule development
created_by: donghui
creation_date: 2009-04-13T02:58:07Z

[Term]
id: GO:0080061
name: indole-3-acetonitrile nitrilase activity
namespace: molecular_function
def: "Catalysis of the reaction: indole-3-acetonitrile + 2 H2O = indole-3-acetic acid + NH3." [EC:3.5.5.1, MetaCyc:RXN-1404]
is_a: GO:0000257 ! nitrilase activity
created_by: donghui
creation_date: 2009-04-13T03:30:42Z

[Term]
id: GO:0080062
name: cytokinin 9-beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-alkylaminopurine + UDP-D-glucose = 6-alkylamino-9-beta-D-glucosylpurine + H+ + UDP. This reaction is an N-glucosylation event." [KEGG:R08369, PMID:15342621]
xref: EC:2.4.1.-
xref: KEGG:R08369
is_a: GO:0035251 ! UDP-glucosyltransferase activity
created_by: donghui
creation_date: 2009-04-13T03:34:38Z

[Term]
id: GO:0080064
name: 4,4-dimethyl-9beta,19-cyclopropylsterol oxidation
namespace: biological_process
def: "A lipid oxidation process proceeding through a series of three successive monooxygenations of the alpha methyl group on the C4 carbon (CH3 to CH2OH to CHO to COOH) and resulting in this overall reaction: 4,4-dimethyl-9beta,19-cyclopropylsterol + 3 NADPH + 3 H+ + 3 O2 = 4-alpha-carboxy, 4-beta-methyl-9beta,19-cyclopropylsterol + 3 NADP+ + 3 H2O." [GOC:pr, PMID:14653780]
synonym: "4,4-dimethyl-9beta,19-cyclopropylsterol-4alpha-methyl oxidase activity" RELATED []
is_a: GO:0034440 ! lipid oxidation
created_by: donghui
creation_date: 2009-04-13T03:39:58Z

[Term]
id: GO:0080065
name: 4-alpha-methyl-delta7-sterol oxidation
namespace: biological_process
def: "A lipid oxidation process proceeding through a series of three successive monooxygenations of the alpha methyl group on the C4 carbon (CH3 to CH2OH to CHO to COOH) and resulting in this overall reaction: 4-alpha-methyl-delta7-sterol + 3 NADPH + 3 H+ + 3 O2 = 4-alpha-carboxy,delta7-sterol + 3 NADP+ + 3 H2O." [GOC:pr, PMID:14653780]
synonym: "4-alpha-methyl-delta7-sterol-4alpha-methyl oxidase activity" RELATED []
is_a: GO:0034440 ! lipid oxidation
created_by: donghui
creation_date: 2009-04-13T03:41:50Z

[Term]
id: GO:0080066
name: 3-methylthiopropyl-desulfoglucosinolate sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-methylthiopropyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 3-methylthiopropyl-glucosinolate + adenosine 3',5'-bisphosphate." [PMID:19077143]
xref: MetaCyc:RXN-2209
is_a: GO:0047364 ! desulfoglucosinolate sulfotransferase activity
created_by: donghui
creation_date: 2009-04-13T04:04:08Z

[Term]
id: GO:0080067
name: 4-methylthiobutyl-desulfoglucosinolate sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-methylthiobutyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 4-methylthiobutyl-glucosinolate + adenosine 3',5'-bisphosphate." [PMID:19077143]
xref: MetaCyc:RXNQT-4329
is_a: GO:0047364 ! desulfoglucosinolate sulfotransferase activity
created_by: donghui
creation_date: 2009-04-13T04:05:53Z

[Term]
id: GO:0080068
name: 5-methylthiopentyl-desulfoglucosinolate sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-methylthiopentyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 5-methylthiopentyl-glucosinolate + adenosine 3',5'-bisphosphate." [PMID:19077143]
xref: MetaCyc:RXNQT-4330
is_a: GO:0047364 ! desulfoglucosinolate sulfotransferase activity
created_by: donghui
creation_date: 2009-04-13T04:06:59Z

[Term]
id: GO:0080069
name: 7-methylthioheptyl-desulfoglucosinolate sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7-methylthioheptyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 7-methylthioheptyl-glucosinolate + adenosine 3',5'-bisphosphate." [PMID:19077143]
xref: MetaCyc:RXNQT-4332
is_a: GO:0047364 ! desulfoglucosinolate sulfotransferase activity
created_by: donghui
creation_date: 2009-04-13T04:07:32Z

[Term]
id: GO:0080070
name: 8-methylthiooctyl-desulfoglucosinolate sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 8-methylthiooctyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 8-methylthiooctyl-glucosinolate + adenosine 3',5'-bisphosphate." [PMID:19077143]
xref: MetaCyc:RXNQT-4333
is_a: GO:0047364 ! desulfoglucosinolate sulfotransferase activity
created_by: donghui
creation_date: 2009-04-13T04:07:58Z

[Term]
id: GO:0080071
name: indol-3-yl-methyl-desulfoglucosinolate sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: indol-3-yl-methyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = indol-3-yl-methyl-glucosinolate + adenosine 3',5'-bisphosphate." [PMID:19077143]
xref: MetaCyc:RXN-1443
is_a: GO:0047364 ! desulfoglucosinolate sulfotransferase activity
created_by: donghui
creation_date: 2009-04-13T04:08:33Z

[Term]
id: GO:0080072
name: spermidine:sinapoyl CoA N-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a sinapoyl group to a nitrogen atom on the spermidine molecule." [PMID:19077165]
is_a: GO:0016410 ! N-acyltransferase activity
created_by: donghui
creation_date: 2009-04-13T04:16:28Z

[Term]
id: GO:0080073
name: spermidine:coumaroyl CoA N-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a coumaroyl group to a nitrogen atom on the spermidine molecule." [PMID:19077165]
is_a: GO:0016410 ! N-acyltransferase activity
created_by: donghui
creation_date: 2009-04-13T04:16:59Z

[Term]
id: GO:0080074
name: spermidine:caffeoyl CoA N-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a caffeoyl group to a nitrogen atom on the spermidine molecule." [PMID:19077165]
is_a: GO:0016410 ! N-acyltransferase activity
created_by: donghui
creation_date: 2009-04-13T04:17:23Z

[Term]
id: GO:0080075
name: spermidine:feruloyl CoA N-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a feruloyl group to a nitrogen atom on the spermidine molecule." [PMID:19077165]
is_a: GO:0016410 ! N-acyltransferase activity
created_by: donghui
creation_date: 2009-04-13T04:17:50Z

[Term]
id: GO:0080076
name: caffeoyl CoA:S-adenosyl-L-methionine O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the oxygen atom of a caffeoyl CoA molecule." [PMID:19077165]
is_a: GO:0008171 ! O-methyltransferase activity
created_by: donghui
creation_date: 2009-04-14T03:55:49Z

[Term]
id: GO:0080077
name: trihydroxyferuloyl spermidine:S-adenosyl-L-methionine O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the oxygen atom of a trihydroxyferuloyl spermidine molecule." [PMID:19077165]
is_a: GO:0008171 ! O-methyltransferase activity
created_by: donghui
creation_date: 2009-04-14T04:00:45Z

[Term]
id: GO:0080078
name: tricaffeoyl spermidine:S-adenosyl-L-methionine O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the oxygen atom of a tricaffeoyl spermidine molecule." [PMID:19077165]
is_a: GO:0008171 ! O-methyltransferase activity
created_by: donghui
creation_date: 2009-04-14T04:01:25Z

[Term]
id: GO:0080079
name: cellobiose glucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: cellobiose + H2O = 2 D-glucose." [PMID:15604686]
synonym: "cellobiose glucohydrolase activity" EXACT []
xref: MetaCyc:RXN-10773
is_a: GO:0008422 ! beta-glucosidase activity
created_by: donghui
creation_date: 2009-04-14T04:07:16Z

[Term]
id: GO:0080081
name: 4-methylumbelliferyl-beta-D-glucopyranoside beta-glucosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of glucosidic link in 4-methylumbelliferyl-beta-D-glucopyranoside." [PMID:15604686]
is_a: GO:0008422 ! beta-glucosidase activity
created_by: donghui
creation_date: 2009-04-14T04:09:06Z

[Term]
id: GO:0080082
name: esculin beta-glucosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of glucosidic link in esculin." [PMID:15604686]
is_a: GO:0008422 ! beta-glucosidase activity
created_by: donghui
creation_date: 2009-04-14T04:09:42Z

[Term]
id: GO:0080083
name: beta-gentiobiose beta-glucosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of glucosidic link in beta-gentiobiose." [PMID:15604686]
is_a: GO:0008422 ! beta-glucosidase activity
created_by: donghui
creation_date: 2009-04-14T04:10:14Z

[Term]
id: GO:0080084
name: 5S rDNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the 5S rDNA sequence encoding ribosomal 5S rRNA, which is individually transcribed by RNA polymerase III, rather than by RNA polymerase I, in species where it exists." [PMID:12711688]
is_a: GO:0000182 ! rDNA binding
created_by: donghui
creation_date: 2009-04-22T02:32:20Z

[Term]
id: GO:0080085
name: signal recognition particle, chloroplast targeting
namespace: cellular_component
def: "A complex consisting of a protein and RNA component which binds the signal sequence of some proteins and facilitates their export to the chloroplast." [PMID:17513500]
is_a: GO:0048500 ! signal recognition particle
created_by: donghui
creation_date: 2009-04-22T02:36:01Z

[Term]
id: GO:0080086
name: stamen filament development
namespace: biological_process
def: "The process whose specific outcome is the progression of the filament over time, from its formation to the mature structure. Filament is the stalk of a stamen." [PMID:19139039, PO:0009067]
synonym: "filament development" EXACT []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048443 ! stamen development
created_by: donghui
creation_date: 2009-04-22T03:12:03Z

[Term]
id: GO:0080088
name: spermidine hydroxycinnamate conjugate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of spermidine hydroxycinnamate conjugates." [PMID:19077165]
is_a: GO:0043604 ! amide biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process
created_by: donghui
creation_date: 2009-04-22T03:24:03Z

[Term]
id: GO:0080089
name: sinapoyl spermidine:sinapoyl CoA N-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a sinapoyl group to a nitrogen atom on the spermidine molecule." [PMID:19168716]
is_a: GO:0016410 ! N-acyltransferase activity
created_by: donghui
creation_date: 2009-04-22T03:27:55Z

[Term]
id: GO:0080090
name: regulation of primary metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [PMID:19211694]
is_a: GO:0019222 ! regulation of metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044238 ! primary metabolic process
relationship: regulates GO:0044238 ! primary metabolic process
created_by: donghui
creation_date: 2009-04-22T04:30:52Z

[Term]
id: GO:0080091
name: regulation of raffinose metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving raffinose." [PMID:19211694]
is_a: GO:0006109 ! regulation of carbohydrate metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0033530 ! raffinose metabolic process
relationship: regulates GO:0033530 ! raffinose metabolic process
created_by: donghui
creation_date: 2009-04-22T04:36:27Z

[Term]
id: GO:0080092
name: regulation of pollen tube growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pollen tube growth." [PMID:19208902]
is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation
is_a: GO:0043900 ! regulation of multi-organism process
is_a: GO:0051239 ! regulation of multicellular organismal process
is_a: GO:0051510 ! regulation of unidimensional cell growth
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009860 ! pollen tube growth
relationship: regulates GO:0009860 ! pollen tube growth
created_by: donghui
creation_date: 2009-04-22T04:41:29Z

[Term]
id: GO:0080093
name: regulation of photorespiration
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of photorespiration. Photorespiration is a light-dependent catabolic process occurring concomitantly with photosynthesis in plants (especially C3 plants) whereby dioxygen (O2) is consumed and carbon dioxide (CO2) is evolved." [GOC:tb]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009853 ! photorespiration
relationship: regulates GO:0009853 ! photorespiration
created_by: donghui
creation_date: 2009-04-22T04:44:48Z

[Term]
id: GO:0080094
name: response to trehalose-6-phosphate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trehalose-6-phosphate stimulus." [PMID:19193861]
synonym: "response to trehalose-6-phosphate stimulus" EXACT [GOC:dos]
is_a: GO:0046683 ! response to organophosphorus
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: donghui
creation_date: 2009-04-22T04:49:13Z

[Term]
id: GO:0080095
name: phosphatidylethanolamine-sterol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a phosphatidylethanolamine + a sterol = a sterol ester + a lysophosphatidylethanolamine." [PMID:16020547]
is_a: GO:0008374 ! O-acyltransferase activity
created_by: donghui
creation_date: 2009-04-23T03:39:33Z

[Term]
id: GO:0080096
name: phosphatidate-sterol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a phosphatidate + a sterol = a sterol ester + a lysophosphatidate." [PMID:16020547]
is_a: GO:0008374 ! O-acyltransferase activity
created_by: donghui
creation_date: 2009-04-23T03:41:42Z

[Term]
id: GO:0080097
name: L-tryptophan:pyruvate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tryptophan + pyruvate = 3-(indol-3-yl)pyruvate + L-alanine." [MetaCyc:RXN-10139]
comment: This reaction falls within the larger set of reactions associated with EC 2.6.1.28 (See BRENDA: http://www.brenda-enzymes.org/php/result_flat.php4?ecno=2.6.1.28; note: 3-indole-2-oxopropanoate = indolepyruvate = 3-(indol-3-yl)pyruvate).
xref: EC:2.6.1.28
xref: MetaCyc:RXN-10139
xref: RHEA:27587
is_a: GO:0070529 ! L-tryptophan aminotransferase activity
created_by: donghui
creation_date: 2009-04-23T03:45:23Z

[Term]
id: GO:0080098
name: L-tyrosine:pyruvate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tyrosine + pyruvate = (4-hydroxyphenyl)pyruvate + L-alanine." [MetaCyc:RXN3O-4157]
xref: EC:2.6.1.58
xref: MetaCyc:RXN3O-4157
is_a: GO:0070547 ! L-tyrosine aminotransferase activity
created_by: donghui
creation_date: 2009-04-23T03:47:53Z

[Term]
id: GO:0080099
name: L-methionine:2-oxoglutarate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-methionine + 2-oxoglutarate = 4-methylthio-2-oxobutyrate + L-glutamate." [PMID:18394996]
comment: This reaction falls within the larger set of reactions associated with EC:2.6.1.5 (See BRENDA: http://www.brenda-enzymes.org/php/result_flat.php4?ecno=2.6.1.5).
synonym: "L-methionine:alpha-ketoglutarate aminotransferase activity" EXACT []
is_a: GO:0010326 ! methionine-oxo-acid transaminase activity
created_by: donghui
creation_date: 2009-04-23T03:51:20Z

[Term]
id: GO:0080100
name: L-glutamine:2-oxoglutarate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamine + 2-oxoglutarate = 2-oxoglutaramate + L-glutamate." [PMID:18394996]
comment: This reaction falls within the larger set of reactions associated with EC:2.6.1.50 (See BRENDA: http://www.brenda-enzymes.org/php/result_flat.php4?ecno=2.6.1.50).
synonym: "L-glutamine:alpha-ketoglutarate aminotransferase activity" EXACT []
xref: EC:2.6.1.50
is_a: GO:0070548 ! L-glutamine aminotransferase activity
created_by: donghui
creation_date: 2009-04-23T03:56:16Z

[Term]
id: GO:0080101
name: phosphatidyl-N-dimethylethanolamine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidyl-N-dimethylethanolamine = S-adenosyl-L-homocysteine + phosphatidylcholine." [EC:2.1.1.71, PMID:19366698]
xref: EC:2.1.1.71
xref: KEGG:R01320
xref: MetaCyc:RXN4FS-2
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
created_by: donghui
creation_date: 2009-04-23T04:02:41Z

[Term]
id: GO:0080102
name: 3-methylthiopropyl glucosinolate S-oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-methylthiopropyl-glucosinolate = 3-methylsulfinylpropyl-glucosinolate." [PMID:18799661]
xref: MetaCyc:RXN-2221
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
created_by: donghui
creation_date: 2009-04-23T04:26:41Z

[Term]
id: GO:0080103
name: 4-methylthiopropyl glucosinolate S-oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-methylthiopropyl-glucosinolate = 4-methylsulfinylpropyl-glucosinolate." [PMID:18799661]
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
created_by: donghui
creation_date: 2009-04-23T04:27:45Z

[Term]
id: GO:0080104
name: 5-methylthiopropyl glucosinolate S-oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-methylthiopropyl-glucosinolate = 5-methylsulfinylpropyl-glucosinolate." [PMID:18799661]
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
created_by: donghui
creation_date: 2009-04-23T04:28:25Z

[Term]
id: GO:0080105
name: 6-methylthiopropyl glucosinolate S-oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-methylthiopropyl-glucosinolate = 6-methylsulfinylpropyl-glucosinolate." [PMID:18799661]
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
created_by: donghui
creation_date: 2009-04-23T04:28:55Z

[Term]
id: GO:0080106
name: 7-methylthiopropyl glucosinolate S-oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7-methylthiopropyl-glucosinolate = 7-methylsulfinylpropyl-glucosinolate." [PMID:18799661]
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
created_by: donghui
creation_date: 2009-04-23T04:29:37Z

[Term]
id: GO:0080107
name: 8-methylthiopropyl glucosinolate S-oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 8-methylthiopropyl-glucosinolate = 8-methylsulfinylpropyl-glucosinolate." [PMID:18799661]
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
created_by: donghui
creation_date: 2009-04-23T04:30:08Z

[Term]
id: GO:0080108
name: S-alkylthiohydroximate lyase activity
namespace: molecular_function
def: "Catalysis of the conversion of a S-alkylthiohydroximate to a thiohydroximate." [PMID:14871316]
synonym: "S-alkylthiohydroximate C-S lyase activity" NARROW []
is_a: GO:0016846 ! carbon-sulfur lyase activity
created_by: donghui
creation_date: 2009-04-23T04:35:14Z

[Term]
id: GO:0080109
name: indole-3-acetonitrile nitrile hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: indole-3-acetonitrile + H2O = indole-3-acetamide." [EC:4.2.1.84, MetaCyc:RXN-7567, PMID:11607511, PMID:12430025]
xref: EC:4.2.1.84
xref: KEGG:R04020
xref: MetaCyc:RXN-7567
is_a: GO:0018822 ! nitrile hydratase activity
created_by: donghui
creation_date: 2009-04-23T04:37:57Z

[Term]
id: GO:0080110
name: sporopollenin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sporopollenin, a primary constituent of the pollen exine layer." [PMID:19218397]
synonym: "sporopollenin biosynthesis" EXACT []
is_a: GO:0019438 ! aromatic compound biosynthetic process
relationship: part_of GO:0010584 ! pollen exine formation
created_by: donghui
creation_date: 2009-04-23T04:44:16Z

[Term]
id: GO:0080111
name: DNA demethylation
namespace: biological_process
def: "The removal of a methyl group from one or more nucleotides within an DNA molecule." [PMID:17208187]
is_a: GO:0035510 ! DNA dealkylation
is_a: GO:0044728 ! DNA methylation or demethylation
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0070988 ! demethylation
created_by: donghui
creation_date: 2009-04-27T02:42:05Z

[Term]
id: GO:0080112
name: seed growth
namespace: biological_process
def: "The increase in size or mass of a seed. A seed is a propagating organ formed in the reproductive cycle of a spermatophyte, derived from the ovule and enclosing an embryo." [GOC:dhl, PO:0009010]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0048589 ! developmental growth
relationship: part_of GO:0048316 ! seed development
created_by: donghui
creation_date: 2009-04-27T02:52:07Z

[Term]
id: GO:0080113
name: regulation of seed growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of growth of the seed of an plant." [PMID:19141706]
synonym: "regulation of seed size" EXACT []
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:0080050 ! regulation of seed development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0080112 ! seed growth
relationship: regulates GO:0080112 ! seed growth
created_by: donghui
creation_date: 2009-04-27T02:55:01Z

[Term]
id: GO:0080114
name: positive regulation of glycine hydroxymethyltransferase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glycine hydroxymethyltransferase activity, the catalysis of the reaction 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine." [EC:2.1.2.1, PMID:19223513]
is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:0051347 ! positive regulation of transferase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004372 ! glycine hydroxymethyltransferase activity
relationship: positively_regulates GO:0004372 ! glycine hydroxymethyltransferase activity
created_by: donghui
creation_date: 2009-04-27T03:27:15Z

[Term]
id: GO:0080115
name: myosin XI tail binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the tail region of a myosin XI heavy chain." [PMID:18703495]
is_a: GO:0032029 ! myosin tail binding
created_by: donghui
creation_date: 2009-04-27T03:31:45Z

[Term]
id: GO:0080116
name: glucuronoxylan glucuronosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of glucuronate to the xylan backbone of glucuronoxylan molecule." [PMID:18980649]
is_a: GO:0015020 ! glucuronosyltransferase activity
created_by: donghui
creation_date: 2009-04-27T03:33:49Z

[Term]
id: GO:0080117
name: secondary growth
namespace: biological_process
def: "Lateral growth of a plant axis (shoot axis or root) that is an increase in thickness resulting from formation of secondary vascular tissues by the vascular cambium." [ISBN:0471245208, PMID:19074290, PO:0005598, PO:0025004]
comment: Occurs in vascular plants, including gymnosperms and most dicotyledons. Commonly supplemented by activity of the cork cambium or phellogen (PO:0005599). Monocotyledons do not have secondary growth, but may undergo primary thickening (GO:0080192) or secondary thickening (GO:0080191), which can give the appearance of secondary growth. Primary and secondary growth can occur simultaneously in the same organism.
synonym: "cambial secondary growth" EXACT []
is_a: GO:0080190 ! lateral growth
created_by: donghui
creation_date: 2009-04-27T03:36:28Z

[Term]
id: GO:0080118
name: brassinosteroid sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a brassinosteroid + 3'-phosphoadenosine-5'-phosphosulfate = sulfated brassinosteroid + adenosine-3',5'-diphosphate. This reaction is the transfer of a sulfate group to the hydroxyl group of a brassinosteroid acceptor, producing the sulfated brassinosteroid derivative." [CHEBI:22921, PMID:10409637, PMID:17039368]
is_a: GO:0008146 ! sulfotransferase activity
created_by: donghui
creation_date: 2009-04-27T03:39:36Z

[Term]
id: GO:0080119
name: ER body organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the formation of ER (endoplasmic reticulum) body. ER body is a compartment found in plant cells that is derived from the ER. The structures have a characteristic shape and size (10 mm long and 0.5 mm wide) and are surrounded with ribosomes. They have been found in Arabidopsis thaliana and related Brassicaceae species." [PMID:18780803, PMID:19147648]
synonym: "endoplasmic reticulum body organization" EXACT []
synonym: "endoplasmic reticulum body organization and biogenesis" RELATED [GOC:mah]
synonym: "ER body organisation" EXACT [GOC:mah]
synonym: "ER body organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization
created_by: donghui
creation_date: 2009-04-27T04:01:26Z

[Term]
id: GO:0080120
name: CAAX-box protein maturation
namespace: biological_process
def: "A series of specific posttranslational modifications to the CAAX box region of CAAX box proteins. CAAX box proteins are eukaryotic proteins that contain a CAAX motif where the C is a cysteine, the two A residues are aliphatic amino acids and the X can be one of several amino acids. The CAAX-box proteins undergo three sequential, enzymatic, post-translational modifications essential to their targeting: First, the proteins are prenylated by one of two prenyltransferases called farnesyltransferase and geranylgeranyltransferase-I. Prenylation results in the covalent attachment of either farnesyl or geranylgeranyl isoprenoid groups to the cysteine in the CAAX box motif. Prenylation is followed by proteolytic removal of the last three amino acids of the protein (AAX). Finally, the newly exposed carboxylate group of the isoprenylcysteine is methylated by an ER-associated prenyl-dependent carboxylmethyltransferase." [PMID:12039957, PMID:17114793, PMID:18641086]
synonym: "CAAX-box protein processing" RELATED []
synonym: "farnesylated protein maturation" RELATED [GOC:vw]
is_a: GO:0044267 ! cellular protein metabolic process
is_a: GO:0051604 ! protein maturation
relationship: has_part GO:0016485 ! protein processing
relationship: has_part GO:0018342 ! protein prenylation
created_by: donghui
creation_date: 2009-04-28T03:06:13Z

[Term]
id: GO:0080121
name: AMP transport
namespace: biological_process
def: "The directed movement of AMP, adenosine monophosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [PMID:18923018]
synonym: "adenosine monophosphate transport" EXACT []
is_a: GO:0015695 ! organic cation transport
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015858 ! nucleoside transport
is_a: GO:0015868 ! purine ribonucleotide transport
is_a: GO:0051503 ! adenine nucleotide transport
created_by: donghui
creation_date: 2009-04-28T04:01:37Z

[Term]
id: GO:0080122
name: AMP transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of AMP, adenosine monophosphate, from one side of a membrane to the other." [PMID:18923018]
synonym: "adenosine monophosphate transmembrane transporter activity" EXACT []
is_a: GO:0000295 ! adenine nucleotide transmembrane transporter activity
is_a: GO:0005346 ! purine ribonucleotide transmembrane transporter activity
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:0015211 ! purine nucleoside transmembrane transporter activity
relationship: part_of GO:0080121 ! AMP transport
created_by: donghui
creation_date: 2009-04-28T04:05:39Z

[Term]
id: GO:0080123
name: jasmonate-amino synthetase activity
namespace: molecular_function
def: "Catalysis of the reaction: jasmonate + an amino acid = an amide-linked jasmonyl-amino acid conjugate. The substrates of this reaction include non-standard amino acids, such as ACC (1-aminocyclopropane-1-carboxylate)." [PMID:15258265, PMID:17291501]
synonym: "ja-amino synthetase activity" EXACT []
synonym: "jasmonate-amido synthetase activity" EXACT []
synonym: "jasmonate-amino acid conjugate synthetase activity" EXACT []
synonym: "jasmonate-amino acid synthetase activity" EXACT []
synonym: "jasmonate:amino acid synthetase activity" EXACT []
synonym: "jasmonic acid-amino synthetase activity" EXACT []
synonym: "jasmonyl-amino synthetase activity" EXACT []
is_a: GO:0016881 ! acid-amino acid ligase activity
created_by: donghui
creation_date: 2009-04-28T04:08:35Z

[Term]
id: GO:0080124
name: pheophytinase activity
namespace: molecular_function
def: "Catalysis of the reaction: pheophytin + H2O = phytol + pheophorbide." [PMID:19304936]
synonym: "pheophytin pheophorbide hydrolase activity" EXACT []
is_a: GO:0052689 ! carboxylic ester hydrolase activity
created_by: donghui
creation_date: 2009-04-28T04:16:11Z

[Term]
id: GO:0080125
name: multicellular structure septum development
namespace: biological_process
def: "The process whose specific outcome is the progression of the multicellular structure septum over time, from its formation to the mature structure. The multicellular structure septum is the thin partition or membrane that divides a cavity or a mass of tissue." [GOC:dhl]
is_a: GO:0009888 ! tissue development
relationship: part_of GO:0048513 ! animal organ development
created_by: donghui
creation_date: 2009-04-28T04:31:14Z

[Term]
id: GO:0080126
name: ovary septum development
namespace: biological_process
def: "The process whose specific outcome is the progression of the ovary septum over time, from its formation to the mature structure. The ovary septum is the thin partition that divides the ovary, the basal portion of a carpel or group of fused carpels, that encloses the ovule(s)." [PMID:17855426]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0080125 ! multicellular structure septum development
relationship: part_of GO:0035670 ! plant-type ovary development
created_by: donghui
creation_date: 2009-04-28T04:34:39Z

[Term]
id: GO:0080127
name: fruit septum development
namespace: biological_process
def: "The process whose specific outcome is the progression of the fruit septum over time, from its formation to the mature structure. The fruit septum is a thin partition or membrane that divides a cavity or a mass of tissue in the fruit." [GOC:dhl, PO:0005008]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0009791 ! post-embryonic development
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0080125 ! multicellular structure septum development
relationship: part_of GO:0010154 ! fruit development
created_by: donghui
creation_date: 2009-04-28T04:37:19Z

[Term]
id: GO:0080128
name: anther septum development
namespace: biological_process
def: "The process whose specific outcome is the progression of the anther septum over time, from its formation to the mature structure. The anther septum is a thin partition or stretch of cells that are present in the anther dehiscence zone." [GOC:dhl, PO:0005010]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0080125 ! multicellular structure septum development
relationship: part_of GO:0048653 ! anther development
created_by: donghui
creation_date: 2009-04-28T04:41:16Z

[Term]
id: GO:0080129
name: proteasome core complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a mature, active 20S proteasome core particle complex that does not contain any regulatory particles." [PMID:12401807, PMID:17971041]
synonym: "20S proteasome assembly" EXACT []
is_a: GO:0043248 ! proteasome assembly
created_by: donghui
creation_date: 2009-04-29T03:34:50Z

[Term]
id: GO:0080130
name: L-phenylalanine:2-oxoglutarate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-phenylalanine + 2-oxoglutarate = phenylpyruvate + L-glutamate." [GOC:pmn_curators, PMID:18394996]
comment: This reaction falls within the larger set of reactions associated with EC 2.6.1.57 and several other EC numbers (See BRENDA:http://www.brenda-enzymes.org/php/result_flat.php4?ecno=2.6.1.57).
synonym: "L-phenylalanine:alpha-ketoglutarate aminotransferase activity" EXACT []
xref: EC:2.6.1.1
xref: EC:2.6.1.5
xref: EC:2.6.1.57
xref: EC:2.6.1.9
xref: KEGG:R00694
xref: MetaCyc:PHEAMINOTRANS-RXN
xref: MetaCyc:RXN-10814
xref: RHEA:25155
is_a: GO:0070546 ! L-phenylalanine aminotransferase activity
created_by: donghui
creation_date: 2009-04-29T03:42:47Z

[Term]
id: GO:0080131
name: hydroxyjasmonate sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a hydroxyjasmonate + 3'-phosphoadenosine-5'-phosphosulfate = a hydroxyjasmonate sulfate + adenosine-3',5'-diphosphate." [EC:2.8.2.-, GOC:pmn_curators, MetaCyc:RXN-10451, MetaCyc:RXN-10453, PMID:12637544]
synonym: "11-hydroxyjasmonate sulfotransferase activity" NARROW [MetaCyc:RXN-10453]
synonym: "11-hydroxyjasmonic acid sulfotransferase activity" NARROW [MetaCyc:RXN-10453]
synonym: "11-OHJA sulfotransferase activity" NARROW [MetaCyc:RXN-10453]
synonym: "12-hydroxyjasmonate sulfotransferase activity" NARROW [MetaCyc:RXN-10451]
synonym: "12-hydroxyjasmonic acid sulfotransferase activity" NARROW [MetaCyc:RXN-10451]
synonym: "12-OHJA sulfotransferase activity" NARROW [MetaCyc:RXN-10451]
synonym: "hydroxyjasmonic acid sulfotransferase activity" EXACT []
synonym: "OHJA sulfotransferase activity" EXACT []
xref: EC:2.8.2.-
is_a: GO:0008146 ! sulfotransferase activity
created_by: donghui
creation_date: 2009-04-29T03:47:12Z

[Term]
id: GO:0080132
name: fatty acid alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the conversion of a fatty acid to an alpha-hydroxylated fatty acid. A hydroxyl group is added to the second carbon, counted from the carboxyl end, of a fatty acid chain." [PMID:19054355]
synonym: "fatty acid 2-hydroxylase" EXACT []
is_a: GO:0016491 ! oxidoreductase activity
created_by: donghui
creation_date: 2009-05-06T04:43:36Z

[Term]
id: GO:0080133
name: midchain alkane hydroxylase activity
namespace: molecular_function
def: "Catalysis of the conversion of an alkane to a secondary alcohol." [PMID:17905869]
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
created_by: donghui
creation_date: 2009-05-06T04:46:17Z

[Term]
id: GO:0080134
name: regulation of response to stress
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
is_a: GO:0048583 ! regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006950 ! response to stress
relationship: regulates GO:0006950 ! response to stress
created_by: donghui
creation_date: 2009-05-06T04:51:28Z

[Term]
id: GO:0080135
name: regulation of cellular response to stress
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl]
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:0080134 ! regulation of response to stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0033554 ! cellular response to stress
relationship: regulates GO:0033554 ! cellular response to stress
created_by: donghui
creation_date: 2009-05-06T05:02:52Z

[Term]
id: GO:0080136
name: priming of cellular response to stress
namespace: biological_process
def: "The process that enables cells to respond in a more rapid and robust manner than nonprimed cells to much lower levels of a stimulus indicating the organism is under stress." [PMID:19318610]
synonym: "priming of response to stress" BROAD []
synonym: "priming of stress response" BROAD []
is_a: GO:0080135 ! regulation of cellular response to stress
relationship: part_of GO:0033554 ! cellular response to stress
created_by: donghui
creation_date: 2009-05-06T05:05:15Z

[Term]
id: GO:0080138
name: borate uptake transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of borate from the outside of a cell to the inside of the cell across a membrane." [PMID:18603465]
synonym: "boron uptake transmembrane transporter activity" RELATED [GOC:curators]
is_a: GO:0015563 ! uptake transmembrane transporter activity
is_a: GO:0046715 ! borate transmembrane transporter activity
created_by: donghui
creation_date: 2009-05-19T04:09:56Z

[Term]
id: GO:0080139
name: borate efflux transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of borate from the inside of the cell to the outside of the cell across a membrane." [PMID:18603465]
synonym: "boron efflux transmembrane transporter activity" RELATED [GOC:curators]
is_a: GO:0015562 ! efflux transmembrane transporter activity
is_a: GO:0046715 ! borate transmembrane transporter activity
created_by: donghui
creation_date: 2009-05-19T04:11:45Z

[Term]
id: GO:0080140
name: regulation of jasmonic acid metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving jasmonic acid." [GOC:dhl]
is_a: GO:0019217 ! regulation of fatty acid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009694 ! jasmonic acid metabolic process
relationship: regulates GO:0009694 ! jasmonic acid metabolic process
created_by: donghui
creation_date: 2009-05-19T04:24:55Z

[Term]
id: GO:0080141
name: regulation of jasmonic acid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of jasmonic acid." [GOC:dhl]
is_a: GO:0042304 ! regulation of fatty acid biosynthetic process
is_a: GO:0080140 ! regulation of jasmonic acid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009695 ! jasmonic acid biosynthetic process
relationship: regulates GO:0009695 ! jasmonic acid biosynthetic process
created_by: donghui
creation_date: 2009-05-19T04:28:39Z

[Term]
id: GO:0080142
name: regulation of salicylic acid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of salicylic acid." [GOC:dhl]
is_a: GO:0010337 ! regulation of salicylic acid metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009697 ! salicylic acid biosynthetic process
relationship: regulates GO:0009697 ! salicylic acid biosynthetic process
created_by: donghui
creation_date: 2009-05-19T04:38:23Z

[Term]
id: GO:0080143
name: regulation of amino acid export
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of amino acid export. Amino acid export is the directed movement of amino acids out of a cell or organelle." [PMID:20018597]
is_a: GO:0051955 ! regulation of amino acid transport
relationship: regulates GO:0032973 ! amino acid export
created_by: donghui
creation_date: 2010-01-20T04:43:56Z

[Term]
id: GO:0080144
name: amino acid homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of amino acid within an organism or cell." [PMID:19955263]
is_a: GO:0055081 ! anion homeostasis
created_by: donghui
creation_date: 2010-01-27T04:47:27Z

[Term]
id: GO:0080145
name: cysteine homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of cysteine within an organism or cell." [PMID:19955263]
is_a: GO:0055080 ! cation homeostasis
is_a: GO:0080144 ! amino acid homeostasis
created_by: donghui
creation_date: 2010-01-27T04:49:14Z

[Term]
id: GO:0080146
name: L-cysteine desulfhydrase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-cysteine + H2O = ammonia + pyruvate + hydrogen sulfide + H+." [MetaCyc:LCYSDESULF-RXN, PMID:19955263]
xref: EC:4.4.1.1
xref: MetaCyc:LCYSDESULF-RXN
xref: Reactome:REACT_115816 "Cysteine is degraded to serine and H2S, Homo sapiens"
xref: Reactome:REACT_116121 "Excess cysteine yields lanthionine and H2S, Homo sapiens"
is_a: GO:0016846 ! carbon-sulfur lyase activity
created_by: donghui
creation_date: 2010-01-27T04:50:43Z

[Term]
id: GO:0080147
name: root hair cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a root hair cell over time, from its formation to the mature state." [PMID:19675148]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0048765 ! root hair cell differentiation
created_by: donghui
creation_date: 2010-03-26T01:45:08Z

[Term]
id: GO:0080148
name: negative regulation of response to water deprivation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to water deprivation. Response to water deprivation is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water." [PMID:18835996]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:2000070 ! regulation of response to water deprivation
relationship: negatively_regulates GO:0009414 ! response to water deprivation
created_by: donghui
creation_date: 2010-03-26T01:58:11Z

[Term]
id: GO:0080149
name: sucrose induced translational repression
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate of translation as a result of increase in sucrose level." [PMID:19403731]
synonym: "negative regulation of translation in response to sucrose" EXACT []
is_a: GO:0032055 ! negative regulation of translation in response to stress
created_by: donghui
creation_date: 2010-03-26T04:13:15Z

[Term]
id: GO:0080150
name: S-adenosyl-L-methionine:benzoic acid carboxyl methyl transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzoate + S-adenosyl-L-methionine = methylbenzoate + S-adenosyl-L-homocysteine." [MetaCyc:RXN-6722, PMID:10852939]
synonym: "S-adenosyl-L-methionine:benzoate carboxyl methyltransferase activity" EXACT []
xref: MetaCyc:RXN-6722
is_a: GO:0008171 ! O-methyltransferase activity
created_by: donghui
creation_date: 2010-03-26T04:19:39Z

[Term]
id: GO:0080151
name: positive regulation of salicylic acid mediated signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of salicylic acid mediated signal transduction." [PMID:20181750]
synonym: "positive regulation of salicylic acid mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:2000031 ! regulation of salicylic acid mediated signaling pathway
relationship: positively_regulates GO:0009863 ! salicylic acid mediated signaling pathway
created_by: donghui
creation_date: 2010-05-20T03:10:46Z

[Term]
id: GO:0080152
name: regulation of reductive pentose-phosphate cycle
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of reductive pentose-phosphate cycle." [PMID:17031544]
synonym: "regulation of C3 photosynthesis" NARROW []
synonym: "regulation of Calvin cycle" NARROW []
is_a: GO:0010110 ! regulation of photosynthesis, dark reaction
relationship: regulates GO:0019253 ! reductive pentose-phosphate cycle
created_by: donghui
creation_date: 2010-07-01T02:49:55Z

[Term]
id: GO:0080153
name: negative regulation of reductive pentose-phosphate cycle
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the reductive pentose-phosphate cycle." [PMID:17031544, PMID:20399532]
synonym: "negative regulation of C3 photosynthesis" NARROW []
synonym: "negative regulation of Calvin cycle" NARROW []
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:0080152 ! regulation of reductive pentose-phosphate cycle
is_a: GO:1905156 ! negative regulation of photosynthesis
relationship: negatively_regulates GO:0019253 ! reductive pentose-phosphate cycle
created_by: donghui
creation_date: 2010-07-01T02:55:27Z

[Term]
id: GO:0080154
name: regulation of fertilization
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." [GOC:DHL, PMID:20478994]
is_a: GO:0043900 ! regulation of multi-organism process
is_a: GO:2000241 ! regulation of reproductive process
relationship: regulates GO:0009566 ! fertilization
created_by: donghui
creation_date: 2010-09-01T03:44:27Z

[Term]
id: GO:0080155
name: regulation of double fertilization forming a zygote and endosperm
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of double fertilization forming a zygote and endosperm. Double fertilization forming a zygote and endosperm is a type of fertilization where one of the two sperm nuclei from the pollen tube fuses with the egg nucleus to form a 2n zygote, and the other fuses with the two polar nuclei to form the 3n primary endosperm nucleus and then develops into the endosperm. The ploidy level of the 2n zygote and 3n primary endosperm nucleus is determined by the ploidy level of the parents involved. An example of this component is found in Arabidopsis thaliana." [GOC:DHL, PMID:20478994]
is_a: GO:0080154 ! regulation of fertilization
relationship: regulates GO:0009567 ! double fertilization forming a zygote and endosperm
created_by: donghui
creation_date: 2010-09-01T03:46:39Z

[Term]
id: GO:0080156
name: mitochondrial mRNA modification
namespace: biological_process
def: "The covalent alteration within the mitochondrion of one or more nucleotides within an mRNA to produce an mRNA molecule with a sequence that differs from that coded genetically." [PMID:20566637]
synonym: "mitochondrial mRNA editing" NARROW []
synonym: "mitochondrial RNA editing" BROAD []
is_a: GO:0016556 ! mRNA modification
is_a: GO:1900864 ! mitochondrial RNA modification
intersection_of: GO:0016556 ! mRNA modification
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion
created_by: donghui
creation_date: 2010-09-01T03:55:48Z

[Term]
id: GO:0080157
name: regulation of plant-type cell wall organization or biogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving plant-type cell wall organization or biogenesis. Plant-type cell wall organization or biogenesis is a process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellulose- and pectin-containing cell wall." [PMID:20530756]
synonym: "regulation of plant-type cell wall organisation or biogenesis" EXACT [GOC:mah]
is_a: GO:1903338 ! regulation of cell wall organization or biogenesis
relationship: regulates GO:0071669 ! plant-type cell wall organization or biogenesis
created_by: donghui
creation_date: 2010-09-01T04:02:37Z

[Term]
id: GO:0080158
name: chloroplast ribulose bisphosphate carboxylase complex biogenesis
namespace: biological_process
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a chloroplast ribulose bisphosphate carboxylase (RubisCO) complex. Includes the synthesis of the constituent protein molecules, and those protein modifications that are involved in synthesis or assembly of the complex." [PMID:20561259]
is_a: GO:0070271 ! protein complex biogenesis
created_by: donghui
creation_date: 2010-09-01T04:05:55Z

[Term]
id: GO:0080159
name: zygote elongation
namespace: biological_process
def: "The process in which the zygote irreversibly increases in size in one dimension after fertilization. An example of such a process is found in Arabidopsis thaliana." [GOC:tb]
is_a: GO:0009826 ! unidimensional cell growth
is_a: GO:0048598 ! embryonic morphogenesis
created_by: donghui
creation_date: 2010-09-01T04:07:51Z

[Term]
id: GO:0080160
name: selenate transport
namespace: biological_process
def: "The directed movement of selenate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [PMID:18761637]
is_a: GO:0015698 ! inorganic anion transport
created_by: donghui
creation_date: 2010-09-01T04:17:38Z

[Term]
id: GO:0080161
name: auxin transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of auxins from one side of the membrane to the other. Auxins are plant hormones that regulate aspects of plant growth." [PMID:19506555]
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity
created_by: donghui
creation_date: 2010-09-23T03:37:43Z

[Term]
id: GO:0080162
name: intracellular auxin transport
namespace: biological_process
def: "The directed movement of auxins within a cell. Auxins are a group of plant hormones that regulates aspects of plant growth." [PMID:19506555]
is_a: GO:0060919 ! auxin influx
is_a: GO:1902582 ! single-organism intracellular transport
intersection_of: GO:0060918 ! auxin transport
intersection_of: occurs_in GO:0005622 ! intracellular
relationship: occurs_in GO:0005622 ! intracellular
created_by: donghui
creation_date: 2010-09-23T03:46:29Z

[Term]
id: GO:0080163
name: regulation of protein serine/threonine phosphatase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein serine/threonine phosphatase activity: catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate." [PMID:19407142]
synonym: "regulation of protein phosphatase type 2c activity" NARROW []
is_a: GO:0043666 ! regulation of phosphoprotein phosphatase activity
relationship: regulates GO:0004722 ! protein serine/threonine phosphatase activity
created_by: donghui
creation_date: 2010-09-23T03:51:37Z

[Term]
id: GO:0080164
name: regulation of nitric oxide metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water." [GOC:DHL]
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
is_a: GO:2000377 ! regulation of reactive oxygen species metabolic process
relationship: regulates GO:0046209 ! nitric oxide metabolic process
created_by: donghui
creation_date: 2010-09-23T04:02:50Z

[Term]
id: GO:0080165
name: callose deposition in phloem sieve plate
namespace: biological_process
def: "Any process in which callose is transported to, and/or maintained in, phloem sieve plate. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls." [PMID:19470642]
is_a: GO:0052545 ! callose localization
created_by: donghui
creation_date: 2010-09-23T04:12:49Z

[Term]
id: GO:0080166
name: stomium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the stomium over time, from its formation to the mature structure. A stomium is a fissure or pore in the anther lobe through which the pollen is released." [GOC:tb]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048653 ! anther development
created_by: donghui
creation_date: 2010-09-23T05:03:40Z

[Term]
id: GO:0080167
name: response to karrikin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a karrikin stimulus. Karrikins are signaling molecules in smoke from burning vegetation that trigger seed germination for many angiosperms (flowering plants)." [PMID:20351290]
is_a: GO:0009628 ! response to abiotic stimulus
created_by: donghui
creation_date: 2010-09-23T05:07:22Z

[Term]
id: GO:0080168
name: abscisic acid transport
namespace: biological_process
def: "The directed movement of abscisic acid into, out of, within or between cells by means of some external agent such as a transporter or pore." [PMID:20133881]
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0046865 ! terpenoid transport
created_by: donghui
creation_date: 2010-09-23T05:08:56Z

[Term]
id: GO:0080169
name: cellular response to boron-containing substance deprivation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of boron obtained from boron-containing substances." [PMID:20059736]
synonym: "cellular response to boron deprivation" EXACT [GOC:curators]
synonym: "cellular response to boron starvation" EXACT []
is_a: GO:0009267 ! cellular response to starvation
is_a: GO:0080029 ! cellular response to boron-containing substance levels
created_by: donghui
creation_date: 2010-09-23T05:10:00Z

[Term]
id: GO:0080170
name: hydrogen peroxide transmembrane transport
namespace: biological_process
def: "The process in which hydrogen peroxide is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute." [GOC:tb]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "hydrogen peroxide membrane transport" EXACT []
is_a: GO:0055085 ! transmembrane transport
created_by: donghui
creation_date: 2010-09-23T05:12:14Z

[Term]
id: GO:0080171
name: lytic vacuole organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lytic vacuole." [PMID:20729380]
synonym: "lytic vacuolar assembly" NARROW []
synonym: "lytic vacuole biogenesis" RELATED []
synonym: "lytic vacuole organisation" EXACT []
synonym: "lytic vacuole organization and biogenesis" RELATED []
is_a: GO:0007033 ! vacuole organization
created_by: donghui
creation_date: 2011-04-25T04:40:46Z

[Term]
id: GO:0080172
name: petal epidermis patterning
namespace: biological_process
def: "The regionalization process that regulates the coordinated growth and establishes the non-random spatial arrangement of the cells in the petal epidermis." [GOC:tb]
is_a: GO:0003002 ! regionalization
created_by: donghui
creation_date: 2011-04-25T04:44:06Z

[Term]
id: GO:0080173
name: male-female gamete recognition during double fertilization
namespace: biological_process
def: "The initial contact step made between the male gamete and the female gamete during double fertilization. An example can be found in Arabidopsis thaliana." [PMID:21123745]
synonym: "gamete recognition" BROAD []
synonym: "male-female gamete recognition" EXACT []
is_a: GO:0009988 ! cell-cell recognition
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
relationship: part_of GO:0009567 ! double fertilization forming a zygote and endosperm
created_by: donghui
creation_date: 2011-04-26T04:58:58Z

[Term]
id: GO:0080175
name: phragmoplast microtubule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in phragmoplast, a plant cell specific structure that forms during late cytokinesis. Phragmoplast serves as a scaffold for cell plate assembly and subsequent formation of a new cell wall separating the two daughter cells." [PMID:19383896]
synonym: "phragmoplast microtubule cytoskeleton organization" EXACT []
synonym: "phragmoplast microtubule organisation" EXACT [GOC:mah]
is_a: GO:0000226 ! microtubule cytoskeleton organization
intersection_of: GO:0000226 ! microtubule cytoskeleton organization
intersection_of: occurs_in GO:0009524 ! phragmoplast
relationship: occurs_in GO:0009524 ! phragmoplast
created_by: donghui
creation_date: 2011-04-28T03:54:11Z

[Term]
id: GO:0080176
name: xyloglucan 1,6-alpha-xylosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of xyloglucan side chains so as to remove unsubstituted D-xylose residues attached to the glucose located at the non-reducing terminus." [PMID:20801759]
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds
created_by: donghui
creation_date: 2011-04-28T04:08:39Z

[Term]
id: GO:0080177
name: plastoglobule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plastoglobule. Plastoglobule is a lipoprotein particle present in chloroplasts. They are rich in non-polar lipids (triglycerides, esters) as well as in prenylquinones, plastoquinone and tocopherols. Plastoglobules are often associated with thylakoid membranes, suggesting an exchange of lipids with thylakoids." [PMID:20813909]
synonym: "plastoglobule organisation" EXACT [GOC:mah]
is_a: GO:0016043 ! cellular component organization
is_a: GO:0044763 ! single-organism cellular process
relationship: part_of GO:0009658 ! chloroplast organization
created_by: donghui
creation_date: 2011-04-28T04:13:07Z

[Term]
id: GO:0080178
name: 5-carbamoylmethyluridine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 5-carbamoylmethyluridine." [GOC:tb]
is_a: GO:0046131 ! pyrimidine ribonucleoside metabolic process
created_by: donghui
creation_date: 2011-04-28T04:36:23Z

[Term]
id: GO:0080179
name: 1-methylguanosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 1-methylguanosine." [GOC:tb]
is_a: GO:1901068 ! guanosine-containing compound metabolic process
created_by: donghui
creation_date: 2011-04-28T04:38:13Z

[Term]
id: GO:0080180
name: 2-methylguanosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 2-methylguanosine." [GOC:tb]
is_a: GO:1901068 ! guanosine-containing compound metabolic process
created_by: donghui
creation_date: 2011-04-28T04:41:01Z

[Term]
id: GO:0080181
name: lateral root branching
namespace: biological_process
def: "Any process involved in the formation of branches in lateral roots." [GOC:tb]
is_a: GO:0001763 ! morphogenesis of a branching structure
relationship: part_of GO:0010102 ! lateral root morphogenesis
created_by: donghui
creation_date: 2011-08-10T04:13:33Z

[Term]
id: GO:0080182
name: histone H3-K4 trimethylation
namespace: biological_process
def: "The modification of histone H3 by addition of three methyl groups to lysine at position 4 of the histone." [GOC:BHF, GOC:se, GOC:tb]
is_a: GO:0018023 ! peptidyl-lysine trimethylation
is_a: GO:0051568 ! histone H3-K4 methylation
created_by: donghui
creation_date: 2011-08-10T04:18:36Z

[Term]
id: GO:0080183
name: response to photooxidative stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as the result of a photooxidative stress, the light-dependent generation of active oxygen species. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [DOI:10.1111/j.1399-3054.1994.tb03042.x]
is_a: GO:0006979 ! response to oxidative stress
created_by: donghui
creation_date: 2011-08-10T04:26:11Z

[Term]
id: GO:0080184
name: response to phenylpropanoid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as the result of a phenylpropanoid stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. A phenylpropanoid is any of secondary metabolites with structures based on a phenylpropane skeleton. The class includes phenylpropanoid esters, flavonoids, anthocyanins, coumarins and many small phenolic molecules. Phenylpropanoids are also precursors of lignin." [CHEBI:26004, GOC:tb]
is_a: GO:0014070 ! response to organic cyclic compound
created_by: donghui
creation_date: 2011-08-10T04:28:21Z

[Term]
id: GO:0080185
name: effector dependent induction by symbiont of host immune response
namespace: biological_process
def: "Any process that involves recognition of an effector, and by which an organism activates, maintains or increases the frequency, rate or extent of the immune response of the host organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The host is defined as the larger of the organisms involved in a symbiotic interaction. Effectors are proteins secreted into the host cell by pathogenic microbes, presumably to alter host immune response signaling. The best characterized effectors are bacterial effectors delivered into the host cell by type III secretion system (TTSS). Effector-triggered immunity (ETI) involves the direct or indirect recognition of an effector protein by the host (for example through plant resistance or R proteins) and subsequent activation of host immune response." [GOC:DHL, PMID:16497589]
synonym: "effector dependent induction by symbiont of host immunity" EXACT []
is_a: GO:0052559 ! induction by symbiont of host immune response
created_by: donghui
creation_date: 2011-08-10T04:33:53Z

[Term]
id: GO:0080186
name: developmental vegetative growth
namespace: biological_process
def: "The increase in size or mass of non-reproductive plant parts." [PO:0007134]
is_a: GO:0048589 ! developmental growth
created_by: donghui
creation_date: 2011-08-17T03:45:53Z

[Term]
id: GO:0080187
name: floral organ senescence
namespace: biological_process
def: "An organ senescence that has as a participant a floral organ." [PMID:21689171, PO:0025395]
comment: Includes senescence of petals, sepals, anthers, and any other plant organ that is part of a flower. Floral organ senescence may follow pollination. In some flowers, the organs of the corolla abscise before they senesce.
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0010260 ! organ senescence
is_a: GO:0044702 ! single organism reproductive process
relationship: part_of GO:0048437 ! floral organ development
created_by: donghui
creation_date: 2012-03-09T04:08:50Z

[Term]
id: GO:0080188
name: RNA-directed DNA methylation
namespace: biological_process
def: "An epigenetic RNA-based gene silencing process first elucidated in plants whereby 24-nt small interfering RNAs (siRNAs) guide DNA methyltransferases to the siRNA-generating genomic loci and other loci that are homologous to the siRNAs for de novo DNA methylation. In general this process consists of three phases: biogenesis of siRNAs, scaffold RNA production, and the formation of the guiding complex that recruits de novo DNA methyltransferases to the target loci." [PMID:21420348]
synonym: "RdDM" EXACT []
is_a: GO:0006306 ! DNA methylation
is_a: GO:0016070 ! RNA metabolic process
is_a: GO:0031047 ! gene silencing by RNA
is_a: GO:0044710 ! single-organism metabolic process
created_by: donghui
creation_date: 2012-05-22T02:22:50Z

[Term]
id: GO:0080189
name: primary growth
namespace: biological_process
def: "Growth of a plant structure from the time of its initiation by an apical meristem until its expansion is completed." [ISBN:0471245208]
comment: Has its inception in the apical meristems (PO:0020144) and continues in their derivative meristems - protoderm (PO:0006210) and procambium (PO:0025275) - even in older tissues. Primary and secondary growth can occur simultaneously in the same organism.
is_a: GO:0040007 ! growth
is_a: GO:0044707 ! single-multicellular organism process
created_by: donghui
creation_date: 2012-12-06T15:20:41Z

[Term]
id: GO:0080190
name: lateral growth
namespace: biological_process
def: "Growth of a plant axis (shoot axis or root) that originates from a lateral meristem." [PO:0020145]
comment: Includes thickening of plant axes (PO:0025004) due to the activity of a cambium (PO:0005597), known as secondary growth and found in most gymnosperms and dicotyledons, a primary thickening meristem (PO:0005039) as found in many monocotyledons, some ferns and some cycads, or secondary thickening meristem, (PO:0025414) as found in some monocotyledons.
is_a: GO:0040007 ! growth
is_a: GO:0044699 ! single-organism process
created_by: donghui
creation_date: 2012-12-06T15:42:28Z

[Term]
id: GO:0080191
name: secondary thickening
namespace: biological_process
def: "Lateral growth of a plant axis (shoot axis or root) that is an increase in thickness resulting from formation of tissue from a secondary thickening meristem." [ISBN:0080374903, JSTOR:4354165, PO:0025004, PO:0025414]
comment: Occurs in shoot axes in some monocotyledons such as Dracaena, and rarely in roots of monocotyledons. Distinct from primary thickening, because it is distant from and generally discontinuous with the apical meristem.
is_a: GO:0080190 ! lateral growth
created_by: donghui
creation_date: 2012-12-06T15:50:33Z

[Term]
id: GO:0080192
name: primary thickening
namespace: biological_process
def: "Lateral growth of a plant axis (shoot axis or root) that is an increase in thickness resulting from the activity of a primary thickening meristem." [ISBN:0471245208, JSTOR:4354165, PO:0005039, PO:0025004]
comment: Occurs in shoot axes and rarely in roots in many monocotyledons.
is_a: GO:0080190 ! lateral growth
created_by: donghui
creation_date: 2012-12-06T15:55:18Z

[Term]
id: GO:0080193
name: diffuse secondary thickening
namespace: biological_process
def: "Lateral growth of the older parts of a stem that occurs when the central parenchyma cells and the not yet fully differentiated fiber cells of the bundle sheaths continue to undergo cell division and expansion for a long period of time, leading to an increase in girth of the stem." [ISBN:0080374903]
comment: Occurs in the stems (PO:0009047) of some Arecaceae (palms).
is_a: GO:0080190 ! lateral growth
created_by: donghui
creation_date: 2012-12-06T15:57:50Z

[Term]
id: GO:0085000
name: modification by symbiont of host morphology or physiology via protein secreted by type V secretion system
namespace: biological_process
def: "The process in which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by a type V secretion system in the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
subset: gosubset_prok
is_a: GO:0044048 ! interaction with host via protein secreted by type V secretion system
is_a: GO:0052046 ! modification by symbiont of host morphology or physiology via secreted substance
created_by: jane
creation_date: 2010-07-09T03:08:54Z

[Term]
id: GO:0085001
name: formation by symbiont of stylet for nutrient acquisition from host
namespace: biological_process
def: "The assembly by a symbiont of a stylet, a hollow protrusible spear-like structure projected into the host cell for the purpose of obtaining nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0052093 ! formation of specialized structure for nutrient acquisition from host
created_by: jane
creation_date: 2010-02-24T01:49:06Z

[Term]
id: GO:0085002
name: interaction with host mediated by secreted substance released by symbiont from symbiotic structure
namespace: biological_process
def: "An interaction with the host organism mediated by a symbiont secreted substance released by specialized structures generated in either organisms as a result of the symbiotic interaction. The term host is used for the larger (macro) of the two members of a symbiosis." [GOC:pamgo_curators]
comment: This term can be used for annotation of structures like the parasitophorous vacuole which are symbiont induced but entirely host-derived, as well as structures like the stylet which are entirely symbiont-derived.
is_a: GO:0052048 ! interaction with host via secreted substance involved in symbiotic interaction
created_by: jane
creation_date: 2010-02-10T02:38:10Z

[Term]
id: GO:0085003
name: interaction with host via secreted substance released from stylet
namespace: biological_process
def: "An interaction with the host organism mediated by a substance released by the other (symbiont) organism via the stylet, a hollow protrusible spear-like structure in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0085002 ! interaction with host mediated by secreted substance released by symbiont from symbiotic structure
created_by: jane
creation_date: 2010-02-10T02:53:56Z

[Term]
id: GO:0085004
name: interaction with host via secreted substance released from haustorium
namespace: biological_process
def: "An interaction with the host organism mediated by a substance released by the other (symbiont) organism via the haustorium, a projection from a cell or tissue that penetrates the host's cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0085002 ! interaction with host mediated by secreted substance released by symbiont from symbiotic structure
created_by: jane
creation_date: 2010-02-10T02:58:39Z

[Term]
id: GO:0085005
name: interaction with host via secreted substance released from invasive hyphae
namespace: biological_process
def: "An interaction with the host organism mediated by a substance released by the other (symbiont) organism via invasive hyphae. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0085002 ! interaction with host mediated by secreted substance released by symbiont from symbiotic structure
created_by: jane
creation_date: 2010-02-10T02:59:51Z

[Term]
id: GO:0085006
name: interaction with host mediated by symbiont secreted substance released from symbiont-containing vacuole
namespace: biological_process
def: "An interaction with the host organism mediated by a substance released by the other (symbiont) organism via a symbiont-containing vacuole, a specialized sac within the host in which the symbiont resides. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "interaction with host mediated by symbiont secreted substance released from parasitophorous vacuole" EXACT []
is_a: GO:0085002 ! interaction with host mediated by secreted substance released by symbiont from symbiotic structure
created_by: jane
creation_date: 2010-02-10T03:00:56Z

[Term]
id: GO:0085007
name: interaction with host via secreted substance released from rhoptry
namespace: biological_process
def: "An interaction with the host organism mediated by a substance released by the other (symbiont) organism via the rhoptry, a large, club-shaped secretory organelle that forms part of the apical complex of an apicomplexan parasite. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0085002 ! interaction with host mediated by secreted substance released by symbiont from symbiotic structure
created_by: jane
creation_date: 2010-02-10T03:02:08Z

[Term]
id: GO:0085008
name: interaction with host via secreted substance released from microneme
namespace: biological_process
def: "An interaction with the host organism mediated by a substance released by the other (symbiont) organism via the microneme, a small, elongated secretory organelle that forms part of the apical complex of an apicomplexan parasite. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0085002 ! interaction with host mediated by secreted substance released by symbiont from symbiotic structure
created_by: jane
creation_date: 2010-02-10T03:03:16Z

[Term]
id: GO:0085009
name: interaction with host mediated by symbiont secreted substance released from Maurer's cleft
namespace: biological_process
def: "An interaction with the host organism mediated by a substance released by the other (symbiont) organism via Maurer's cleft. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "interaction with host mediated by symbiont secreted substance released from Maurers cleft" EXACT []
is_a: GO:0085002 ! interaction with host mediated by secreted substance released by symbiont from symbiotic structure
created_by: jane
creation_date: 2010-02-10T03:08:39Z

[Term]
id: GO:0085010
name: interaction with host mediated by secreted substance entering host via endocytosis
namespace: biological_process
def: "An interaction with the host organism mediated by a secreted substance from the symbiont entering host cells via endocytosis of the substance. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0052048 ! interaction with host via secreted substance involved in symbiotic interaction
created_by: jane
creation_date: 2010-02-10T03:12:31Z

[Term]
id: GO:0085011
name: interaction with host via protein secreted by Sec complex
namespace: biological_process
def: "An interaction with the host organism mediated by a substance secreted by the symbiont organism by a Sec complex. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "interaction with host via protein secreted by Sec secretion system" EXACT []
is_a: GO:0052048 ! interaction with host via secreted substance involved in symbiotic interaction
created_by: jane
creation_date: 2010-02-10T03:18:36Z

[Term]
id: GO:0085012
name: interaction with host via protein secreted by Tat complex
namespace: biological_process
def: "An interaction with the host organism mediated by a substance secreted by the symbiont organism by a Tat complex. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "interaction with host via protein secreted by Tat secretion system" EXACT []
is_a: GO:0052048 ! interaction with host via secreted substance involved in symbiotic interaction
created_by: jane
creation_date: 2010-02-10T03:29:37Z

[Term]
id: GO:0085013
name: interaction with host via protein secreted by type VII secretion system
namespace: biological_process
def: "An interaction with the host organism mediated by a substance secreted by the symbiont organism by a type VII secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0052048 ! interaction with host via secreted substance involved in symbiotic interaction
created_by: jane
creation_date: 2010-02-10T03:31:07Z

[Term]
id: GO:0085014
name: dormancy entry of symbiont in host
namespace: biological_process
def: "Entry into a dormant state of the symbiont within the host organism." [GOC:jl]
is_a: GO:0022611 ! dormancy process
is_a: GO:0044114 ! development of symbiont in host
created_by: jane
creation_date: 2010-05-19T02:33:26Z

[Term]
id: GO:0085015
name: dormancy maintenance of symbiont in host
namespace: biological_process
def: "Any process in which a dormant state is maintained by the symbiont within the host organism." [GOC:jl]
synonym: "non-replicating persistence" EXACT []
synonym: "NRP" EXACT []
is_a: GO:0022611 ! dormancy process
is_a: GO:0044114 ! development of symbiont in host
created_by: jane
creation_date: 2010-05-19T03:17:32Z

[Term]
id: GO:0085016
name: dormancy exit of symbiont in host
namespace: biological_process
def: "Exit from dormant state, also known as resuscitation, of the symbiont within the host organism." [GOC:jl]
synonym: "resuscitation of symbiont" EXACT []
is_a: GO:0022611 ! dormancy process
is_a: GO:0044114 ! development of symbiont in host
created_by: jane
creation_date: 2010-05-19T03:23:07Z

[Term]
id: GO:0085017
name: symbiont entry into host cell forming a symbiont-containing vacuole
namespace: biological_process
def: "The invasion by a symbiont of a cell of its host organism, forming a vacuole in which the parasite resides. The vacuole membrane is formed from lipids and proteins derived from both host and symbiont. Begins when the symbiont attaches on to the host cell membrane which invaginates and deepens as the symbiont enters, and ends when the host cell membrane closes behind the newly-formed vacuole." [GOC:jl, PMID:18665841, PMID:8690024, PMID:9580555]
synonym: "symbiont entry into host cell forming a parasitophorous vacuole" EXACT []
synonym: "symbiont entry into host cell forming a pathogen-containing vacuole" EXACT []
is_a: GO:0030260 ! entry into host cell
created_by: jane
creation_date: 2010-05-20T02:55:34Z

[Term]
id: GO:0085018
name: maintenance of symbiont-containing vacuole by host
namespace: biological_process
def: "The process in which a host organism maintains the structure and function of a symbiont-containing vacuole. The symbiont-containing vacuole is a membrane-bounded vacuole within a host cell in which a symbiont organism resides, and can serve to reduce pathogenicity of invading symbionts by restricting them to the vacuolar compartment." [GOC:jl, GOC:yaf, PMID:18665841]
synonym: "maintenance of parasitophorous vacuole" EXACT []
synonym: "maintenance of pathogen-containing vacuole" EXACT []
synonym: "maintenance of vacuolar integrity during bacterial infection" NARROW []
is_a: GO:0051851 ! modification by host of symbiont morphology or physiology
created_by: jane
creation_date: 2010-05-20T03:58:51Z

[Term]
id: GO:0085019
name: formation by symbiont of a tubovesicular network for nutrient acquisition from host
namespace: biological_process
def: "The assembly of a symbiont-induced complex organelle that comprises of multiple protein and lipid domains for the purpose of obtaining nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "formation of a symbiont- induced tubovesicular network for nutrient acquisition from host" EXACT []
is_a: GO:0052093 ! formation of specialized structure for nutrient acquisition from host
created_by: jane
creation_date: 2010-05-20T04:29:24Z

[Term]
id: GO:0085020
name: protein K6-linked ubiquitination
namespace: biological_process
def: "A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 6 of the ubiquitin monomers, is added to a protein. K6-linked ubiquitination is involved in DNA repair." [GOC:sp]
synonym: "protein K6-linked polyubiquitination" EXACT [GOC:mah]
is_a: GO:0000209 ! protein polyubiquitination
created_by: jane
creation_date: 2010-06-01T03:05:03Z

[Term]
id: GO:0085021
name: modification by symbiont of host morphology or physiology via protein secreted by type I secretion system
namespace: biological_process
def: "The process in which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by a type I secretion system in the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
subset: gosubset_prok
is_a: GO:0044047 ! interaction with host via protein secreted by type I secretion system
is_a: GO:0052046 ! modification by symbiont of host morphology or physiology via secreted substance
created_by: jane
creation_date: 2010-07-09T03:20:44Z

[Term]
id: GO:0085022
name: modification by symbiont of host morphology or physiology via protein secreted by type VI secretion system
namespace: biological_process
def: "The process in which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by a type VI secretion system in the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
subset: gosubset_prok
is_a: GO:0044049 ! interaction with host via protein secreted by type VI secretion system
is_a: GO:0052046 ! modification by symbiont of host morphology or physiology via secreted substance
created_by: jane
creation_date: 2010-07-09T03:32:02Z

[Term]
id: GO:0085023
name: modification by symbiont of host morphology or physiology via protein secreted by type VII secretion system
namespace: biological_process
def: "The process in which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by a type VII secretion system in the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
subset: gosubset_prok
is_a: GO:0052046 ! modification by symbiont of host morphology or physiology via secreted substance
is_a: GO:0085013 ! interaction with host via protein secreted by type VII secretion system
created_by: jane
creation_date: 2010-07-09T03:35:02Z

[Term]
id: GO:0085024
name: modification by symbiont of host morphology or physiology via protein secreted by Sec complex
namespace: biological_process
def: "The process in which an organism (symbiont) effects a change in the structure or function of its host organism, mediated by a substance secreted by the Sec complex in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "modification by symbiont of host morphology or physiology via protein secreted by the Sec secretion system" EXACT []
is_a: GO:0052046 ! modification by symbiont of host morphology or physiology via secreted substance
is_a: GO:0085011 ! interaction with host via protein secreted by Sec complex
created_by: jane
creation_date: 2010-07-09T03:44:31Z

[Term]
id: GO:0085025
name: modification by symbiont of host morphology or physiology via protein secreted by Tat complex
namespace: biological_process
def: "The process in which an organism (symbiont) effects a change in the structure or function of its host organism, mediated by a substance secreted by the Tat complex in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "modification by symbiont of host morphology or physiology via protein secreted by the Tat secretion system" EXACT []
is_a: GO:0052046 ! modification by symbiont of host morphology or physiology via secreted substance
is_a: GO:0085012 ! interaction with host via protein secreted by Tat complex
created_by: jane
creation_date: 2010-07-09T03:47:01Z

[Term]
id: GO:0085026
name: tubovesicular membrane network
namespace: cellular_component
def: "A complex, symbiont-induced host-derived organelle that is comprised of multiple protein and lipid domains." [GOC:pamgo_curators]
synonym: "TVM network" EXACT []
synonym: "TVN" EXACT []
is_a: GO:0033655 ! host cell cytoplasm part
is_a: GO:0043264 ! extracellular non-membrane-bounded organelle
created_by: jane
creation_date: 2010-07-09T03:55:41Z

[Term]
id: GO:0085027
name: entry into host via enzymatic degradation of host anatomical structure
namespace: biological_process
def: "Penetration by symbiont of a host anatomical structure which provides a barrier to symbiont entry, mediated by symbiont degradative enzymes." [GOC:pamgo_curators]
is_a: GO:0044411 ! entry into host through host barriers
created_by: jane
creation_date: 2010-07-09T04:00:22Z

[Term]
id: GO:0085028
name: entry into host via enzymatic degradation of host cuticle
namespace: biological_process
def: "Penetration by symbiont of host physical barriers, mediated by symbiont degradative enzymes." [GOC:pamgo_curators]
is_a: GO:0085027 ! entry into host via enzymatic degradation of host anatomical structure
created_by: jane
creation_date: 2010-07-09T04:02:41Z

[Term]
id: GO:0085029
name: extracellular matrix assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of the extracellular matrix." [GOC:jl]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0030198 ! extracellular matrix organization
created_by: jane
creation_date: 2010-07-14T12:52:49Z

[Term]
id: GO:0085030
name: mutualism
namespace: biological_process
def: "An interaction between two organisms living together in more or less intimate association in a relationship in which both organisms benefit from each other." [GOC:pamgo_curators]
is_a: GO:0044403 ! symbiosis, encompassing mutualism through parasitism
created_by: janelomax
creation_date: 2010-07-27T01:25:21Z

[Term]
id: GO:0085031
name: commensalism
namespace: biological_process
def: "An interaction between two organisms living together in more or less intimate association in a relationship in which one benefits and the other is unaffected." [GOC:pamgo_curators]
is_a: GO:0044403 ! symbiosis, encompassing mutualism through parasitism
created_by: janelomax
creation_date: 2010-07-27T01:27:55Z

[Term]
id: GO:0085032
name: modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of host NF-kappaB-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "modulation by symbiont of host NF-kappaB-mediated signal transduction pathway" EXACT []
is_a: GO:0043122 ! regulation of I-kappaB kinase/NF-kappaB signaling
is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway
created_by: janelomax
creation_date: 2010-07-27T02:13:37Z

[Term]
id: GO:0085033
name: positive regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of host NF-kappaB-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "activation by symbiont of host I-kappaB kinase/NF-kappaB cascade" EXACT []
synonym: "induction by symbiont of host I-kappaB kinase/NF-kappaB cascade" EXACT []
synonym: "positive regulation by symbiont of host NF-kappaB-mediated signal transduction pathway" EXACT []
synonym: "positive regulation by symbiont of nuclear factor kappa-light-chain-enhancer of activated B cells mediated signal transduction pathway" EXACT []
synonym: "stimulation by symbiont of host I-kappaB kinase/NF-kappaB cascade" EXACT []
synonym: "up regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade" EXACT []
synonym: "up-regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade" EXACT []
synonym: "upregulation by symbiont of host I-kappaB kinase/NF-kappaB cascade" EXACT []
is_a: GO:0043123 ! positive regulation of I-kappaB kinase/NF-kappaB signaling
is_a: GO:0085032 ! modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade
created_by: janelomax
creation_date: 2010-07-27T02:47:01Z

[Term]
id: GO:0085034
name: negative regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of host NF-kappaB-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0043124 ! negative regulation of I-kappaB kinase/NF-kappaB signaling
created_by: janelomax
creation_date: 2010-07-27T03:32:44Z

[Term]
id: GO:0085035
name: haustorium
namespace: cellular_component
def: "A projection from a cell or tissue that penetrates the host's cell wall and invaginates the host cell membrane." [GOC:pamgo_curators]
comment: See also: extrahaustorial matrix ; GO:0085036 and extrahaustorial membrane ; GO:0085037.
is_a: GO:0042995 ! cell projection
created_by: janelomax
creation_date: 2010-07-27T03:42:24Z

[Term]
id: GO:0085036
name: extrahaustorial matrix
namespace: cellular_component
def: "The space between the symbiont plasma membrane and the extrahaustorial membrane of the host." [GOC:pamgo_curators]
comment: See also: haustorium ; GO:0085035 and extrahaustorial membrane ; GO:0085037.
is_a: GO:0044217 ! other organism part
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0043655 ! extracellular space of host
created_by: janelomax
creation_date: 2010-07-27T03:58:20Z

[Term]
id: GO:0085037
name: extrahaustorial membrane
namespace: cellular_component
def: "The membrane surrounding the symbiont haustorium during symbiosis, derived from the host plasma membrane." [GOC:pamgo_curators]
comment: See also: haustorium ; GO:0085035 and extrahaustorial matrix ; GO:0085036.
is_a: GO:0033644 ! host cell membrane
relationship: part_of GO:0020002 ! host cell plasma membrane
created_by: janelomax
creation_date: 2010-07-27T04:00:49Z

[Term]
id: GO:0085039
name: extra-invasive hyphal membrane
namespace: cellular_component
def: "A host-derived membrane surrounding the symbiont invasive hypha during symbiosis." [GOC:pamgo_curators]
comment: See also: extra-invasive hyphal space ; GO:0085040.
is_a: GO:0033644 ! host cell membrane
created_by: janelomax
creation_date: 2010-07-27T04:19:46Z

[Term]
id: GO:0085040
name: extra-invasive hyphal space
namespace: cellular_component
def: "The space between the symbiont plasma membrane and the extra-invasive hyphal membrane." [GOC:pamgo_curators]
comment: See also: 'extra-invasive hyphal membrane ; GO:0085039'.
is_a: GO:0044217 ! other organism part
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0043655 ! extracellular space of host
created_by: janelomax
creation_date: 2010-07-27T04:21:26Z

[Term]
id: GO:0085041
name: arbuscule
namespace: cellular_component
def: "Highly branched symbiont haustoria within host root cortex cells, responsible for nutrient exchange." [GOC:pamgo_curators]
comment: See also: periarbuscular membrane ; GO:0085042.
is_a: GO:0085035 ! haustorium
created_by: janelomax
creation_date: 2010-07-27T04:29:03Z

[Term]
id: GO:0085042
name: periarbuscular membrane
namespace: cellular_component
def: "A host-derived membrane surrounding the symbiont arbuscule during symbiosis." [GOC:pamgo_curators]
comment: See also: arbuscule ; GO:0085041.
is_a: GO:0033644 ! host cell membrane
created_by: janelomax
creation_date: 2010-07-27T04:31:37Z

[Term]
id: GO:0085044
name: disassembly by symbiont of host cuticle
namespace: biological_process
def: "The process in which a symbiont organism effects a breakdown of the host organism cuticle. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
synonym: "catabolism of host cuticle" EXACT []
synonym: "degradation of host cuticle" RELATED []
is_a: GO:0052111 ! modification by symbiont of host structure
created_by: janelomax
creation_date: 2010-07-27T01:08:15Z

[Term]
id: GO:0086001
name: cardiac muscle cell action potential
namespace: biological_process
def: "An action potential that occurs in a cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0001508 ! action potential
created_by: tanyaberardini
creation_date: 2011-11-10T07:45:11Z

[Term]
id: GO:0086002
name: cardiac muscle cell action potential involved in contraction
namespace: biological_process
def: "An action potential that occurs in a cardiac muscle cell and is involved in its contraction." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0086001 ! cardiac muscle cell action potential
intersection_of: GO:0086001 ! cardiac muscle cell action potential
intersection_of: part_of GO:0086003 ! cardiac muscle cell contraction
relationship: part_of GO:0086003 ! cardiac muscle cell contraction
created_by: tanyaberardini
creation_date: 2011-11-10T07:45:11Z

[Term]
id: GO:0086003
name: cardiac muscle cell contraction
namespace: biological_process
def: "The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of a cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0070252 ! actin-mediated cell contraction
relationship: part_of GO:0060048 ! cardiac muscle contraction
created_by: tanyaberardini
creation_date: 2011-11-10T07:48:15Z

[Term]
id: GO:0086004
name: regulation of cardiac muscle cell contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac muscle cell contraction." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0055117 ! regulation of cardiac muscle contraction
is_a: GO:1903115 ! regulation of actin filament-based movement
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0086003 ! cardiac muscle cell contraction
relationship: regulates GO:0086003 ! cardiac muscle cell contraction
created_by: tanyaberardini
creation_date: 2011-11-10T07:49:10Z

[Term]
id: GO:0086005
name: ventricular cardiac muscle cell action potential
namespace: biological_process
def: "An action potential that occurs in a ventricular cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0086002 ! cardiac muscle cell action potential involved in contraction
created_by: tanyaberardini
creation_date: 2011-11-10T07:59:36Z

[Term]
id: GO:0086006
name: voltage-gated sodium channel activity involved in cardiac muscle cell action potential
namespace: molecular_function
def: "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0005248 ! voltage-gated sodium channel activity
intersection_of: GO:0005248 ! voltage-gated sodium channel activity
intersection_of: part_of GO:0086012 ! membrane depolarization during cardiac muscle cell action potential
relationship: part_of GO:0086012 ! membrane depolarization during cardiac muscle cell action potential
created_by: tanyaberardini
creation_date: 2011-11-10T08:34:49Z

[Term]
id: GO:0086007
name: voltage-gated calcium channel activity involved in cardiac muscle cell action potential
namespace: molecular_function
def: "Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of a cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0005245 ! voltage-gated calcium channel activity
intersection_of: GO:0005245 ! voltage-gated calcium channel activity
intersection_of: part_of GO:0086012 ! membrane depolarization during cardiac muscle cell action potential
relationship: part_of GO:0086012 ! membrane depolarization during cardiac muscle cell action potential
created_by: tanyaberardini
creation_date: 2011-11-10T08:04:42Z

[Term]
id: GO:0086008
name: voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
namespace: molecular_function
def: "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a cardiac muscle cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0005249 ! voltage-gated potassium channel activity
intersection_of: GO:0005249 ! voltage-gated potassium channel activity
intersection_of: part_of GO:0086013 ! membrane repolarization during cardiac muscle cell action potential
relationship: part_of GO:0086013 ! membrane repolarization during cardiac muscle cell action potential
created_by: tanyaberardini
creation_date: 2011-11-10T08:38:09Z

[Term]
id: GO:0086009
name: membrane repolarization
namespace: biological_process
def: "The process in which ions are transported across a membrane such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0034220 ! ion transmembrane transport
is_a: GO:0042391 ! regulation of membrane potential
created_by: tanyaberardini
creation_date: 2011-11-10T08:13:18Z

[Term]
id: GO:0086010
name: membrane depolarization during action potential
namespace: biological_process
def: "The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0051899 ! membrane depolarization
intersection_of: GO:0051899 ! membrane depolarization
intersection_of: part_of GO:0001508 ! action potential
relationship: part_of GO:0001508 ! action potential
created_by: tanyaberardini
creation_date: 2011-11-10T08:15:05Z

[Term]
id: GO:0086011
name: membrane repolarization during action potential
namespace: biological_process
def: "The process in which ions are transported across a membrane such that the membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0086009 ! membrane repolarization
intersection_of: GO:0086009 ! membrane repolarization
intersection_of: part_of GO:0001508 ! action potential
relationship: part_of GO:0001508 ! action potential
created_by: tanyaberardini
creation_date: 2011-11-10T08:15:05Z

[Term]
id: GO:0086012
name: membrane depolarization during cardiac muscle cell action potential
namespace: biological_process
def: "The process in which cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0086010 ! membrane depolarization during action potential
intersection_of: GO:0051899 ! membrane depolarization
intersection_of: part_of GO:0086001 ! cardiac muscle cell action potential
relationship: part_of GO:0086001 ! cardiac muscle cell action potential
created_by: tanyaberardini
creation_date: 2011-11-10T08:20:33Z

[Term]
id: GO:0086013
name: membrane repolarization during cardiac muscle cell action potential
namespace: biological_process
def: "The process in which ions are transported across a membrane such that the cardiac muscle cell plasma membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0086011 ! membrane repolarization during action potential
is_a: GO:0099622 ! cardiac muscle cell membrane repolarization
intersection_of: GO:0086009 ! membrane repolarization
intersection_of: part_of GO:0086001 ! cardiac muscle cell action potential
relationship: part_of GO:0086001 ! cardiac muscle cell action potential
created_by: tanyaberardini
creation_date: 2011-11-10T08:23:25Z

[Term]
id: GO:0086014
name: atrial cardiac muscle cell action potential
namespace: biological_process
def: "An action potential that occurs in an atrial cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0086002 ! cardiac muscle cell action potential involved in contraction
relationship: part_of GO:0086026 ! atrial cardiac muscle cell to AV node cell signaling
created_by: tanyaberardini
creation_date: 2011-11-10T08:49:13Z

[Term]
id: GO:0086015
name: SA node cell action potential
namespace: biological_process
def: "An action potential that occurs in a sinoatrial node cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "SA node cardiac muscle cell action potential" EXACT []
synonym: "SAN cardiac muscle cell action potential" EXACT []
synonym: "sinoatrial node cardiac muscle cell action potential" EXACT []
synonym: "sinus node cardiac muscle cell action potential" NARROW []
is_a: GO:0086001 ! cardiac muscle cell action potential
relationship: part_of GO:0086018 ! SA node cell to atrial cardiac muscle cell signalling
created_by: tanyaberardini
creation_date: 2011-11-10T08:50:15Z

[Term]
id: GO:0086016
name: AV node cell action potential
namespace: biological_process
def: "An action potential that occurs in an atrioventricular node cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "atrioventricular node cardiac muscle cell action potential" EXACT []
synonym: "AV node cardiac muscle cell action potential" EXACT []
is_a: GO:0086001 ! cardiac muscle cell action potential
relationship: part_of GO:0086027 ! AV node cell to bundle of His cell signaling
created_by: tanyaberardini
creation_date: 2011-11-10T08:58:56Z

[Term]
id: GO:0086017
name: Purkinje myocyte action potential
namespace: biological_process
def: "An action potential that occurs in a Purkinje myocyte." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0086001 ! cardiac muscle cell action potential
relationship: part_of GO:0086029 ! Purkinje myocyte to ventricular cardiac muscle cell signaling
created_by: tanyaberardini
creation_date: 2011-11-10T08:58:56Z

[Term]
id: GO:0086018
name: SA node cell to atrial cardiac muscle cell signalling
namespace: biological_process
def: "Any process that mediates the transfer of information from an SA node cardiomyocyte to an atrial cardiomyocyte." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "SA node cardiac muscle cell to atrial cardiac muscle cell signalling" EXACT []
synonym: "SA node cardiomyocyte to atrial cardiomyocyte signalling" EXACT []
synonym: "SAN cardiomyocyte to atrial cardiomyocyte signalling" EXACT []
synonym: "sinoatrial node cardiomyocyte to atrial cardiomyocyte signalling" EXACT []
synonym: "sinus node cardiomyocyte to atrial cardiomyocyte signalling" NARROW []
is_a: GO:0086019 ! cell-cell signaling involved in cardiac conduction
is_a: GO:0086070 ! SA node cell to atrial cardiac muscle cell communication
created_by: tanyaberardini
creation_date: 2011-11-10T09:15:01Z

[Term]
id: GO:0086019
name: cell-cell signaling involved in cardiac conduction
namespace: biological_process
def: "Any process that mediates the transfer of information from one cell to another and contributes to the heart process that regulates cardiac muscle contraction; beginning with the generation of an action potential in the sinoatrial node and ending with regulation of contraction of the myocardium." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "cell-cell signalling involved in cardiac conduction" EXACT [GOC:mah]
is_a: GO:0007267 ! cell-cell signaling
is_a: GO:0086065 ! cell communication involved in cardiac conduction
intersection_of: GO:0007267 ! cell-cell signaling
intersection_of: part_of GO:0061337 ! cardiac conduction
relationship: part_of GO:0061337 ! cardiac conduction
created_by: dph
creation_date: 2011-11-16T03:43:52Z

[Term]
id: GO:0086020
name: gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling
namespace: molecular_function
def: "A wide pore channel activity that enables a direct cytoplasmic connection from an SA node cell to an atrial cardiomyocyte. The gap junction passes electrical signals between the cells contributing to cardiac conduction." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "gap junction channel activity involved in SA node cell-atrial cardiomyocyte electrical coupling" EXACT []
synonym: "gap junction channel activity involved in SAN cell-atrial cardiomyocyte electrical coupling" EXACT []
synonym: "gap junction channel activity involved in sinoatrial node cell-atrial cardiomyocyte electrical coupling" EXACT []
synonym: "gap junction channel activity involved in sinus node cell-atrial cardiomyocyte electrical coupling" NARROW []
is_a: GO:0086075 ! gap junction channel activity involved in cardiac conduction electrical coupling
intersection_of: GO:0005243 ! gap junction channel activity
intersection_of: part_of GO:0086021 ! SA node cell to atrial cardiac muscle cell communication by electrical coupling
relationship: part_of GO:0086021 ! SA node cell to atrial cardiac muscle cell communication by electrical coupling
created_by: tanyaberardini
creation_date: 2011-11-11T02:08:19Z

[Term]
id: GO:0086021
name: SA node cell to atrial cardiac muscle cell communication by electrical coupling
namespace: biological_process
def: "The process that mediates signaling interactions between an SA node cardiomyocyte and an atrial cardiomyocyte by transfer of current between their adjacent cytoplasms via intercellular protein channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "SA node cardiac muscle cell to atrial cardiac muscle cell communication by electrical coupling" EXACT []
synonym: "SA node cardiomyocyte to atrial cardiomyocyte communication by electrical coupling" EXACT []
synonym: "SAN cardiomyocyte to atrial cardiomyocyte communication by electrical coupling" EXACT []
synonym: "sinoatrial node cardiomyocyte to atrial cardiomyocyte communication by electrical coupling" EXACT []
synonym: "sinus node cardiomyocyte to atrial cardiomyocyte communication by electrical coupling" NARROW []
is_a: GO:0086064 ! cell communication by electrical coupling involved in cardiac conduction
is_a: GO:0086070 ! SA node cell to atrial cardiac muscle cell communication
created_by: tanyaberardini
creation_date: 2011-11-10T09:20:39Z

[Term]
id: GO:0086022
name: SA node cell-atrial cardiac muscle cell adhesion involved in cell communication
namespace: biological_process
def: "The attachment of SA node cardiomyocyte to an atrial cardiomyocyte via adhesion molecules that results in the cells being juxtaposed so that they can communicate." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "SA cardiac muscle cell-atrial cardiac muscle cell adhesion involved in cell communication" EXACT []
synonym: "SA cardiomyocyte-atrial cardiomyocyte adhesion involved in cell communication" EXACT []
synonym: "SAN cardiomyocyte-atrial cardiomyocyte adhesion involved in cell communication" EXACT []
synonym: "sinoatrial node cardiomyocyte-atrial cardiomyocyte adhesion involved in cell communication" EXACT []
synonym: "sinus node cardiomyocyte-atrial cardiomyocyte adhesion involved in cell communication" NARROW []
is_a: GO:0034113 ! heterotypic cell-cell adhesion
is_a: GO:0086042 ! cardiac muscle cell-cardiac muscle cell adhesion
relationship: part_of GO:0086070 ! SA node cell to atrial cardiac muscle cell communication
created_by: tanyaberardini
creation_date: 2011-11-10T09:26:52Z

[Term]
id: GO:0086023
name: adrenergic receptor signaling pathway involved in heart process
namespace: biological_process
def: "A series of molecular signals beginning with a G-protein coupled adrenergic cell surface receptor combining with epinephrine or norepinephrine, which contributes to a circulatory system process carried out by the heart." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "adrenergic receptor signalling pathway involved in heart process" EXACT [GOC:bf]
synonym: "beta-adrenergic receptor signalling pathway involved in heart process" NARROW [GOC:bf]
is_a: GO:0071875 ! adrenergic receptor signaling pathway
is_a: GO:0086103 ! G-protein coupled receptor signaling pathway involved in heart process
intersection_of: GO:0071875 ! adrenergic receptor signaling pathway
intersection_of: part_of GO:0003015 ! heart process
relationship: part_of GO:0003015 ! heart process
created_by: tanyaberardini
creation_date: 2011-11-11T02:51:03Z

[Term]
id: GO:0086024
name: adrenergic receptor signaling pathway involved in positive regulation of heart rate
namespace: biological_process
def: "An adrenergic receptor signaling pathway that contributes to an increase in frequency or rate of heart contraction. Binding of adrenalin or noradrenalin to a beta-adrenergic receptor on the surface of the signal-receiving cell results in the activation of an intracellular Gs protein. Gs activates adenylate cyclase to increase intracellular cyclic-AMP (cAMP) levels. cAMP binds directly to F-channels to allow an inward flow of sodium (known as funny current, or If current). The funny current is responsible for membrane depolarization and an increase in heart rate." [GOC:bf, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:21099118]
synonym: "activation of funny current by beta-adrenergic receptor signaling pathway" RELATED [GOC:mtg_cardiac_conduct_nov11]
synonym: "adenylate cyclase-activating cardiac adrenergic receptor signaling pathway" RELATED [GOC:mtg_cardiac_conduct_nov11]
synonym: "adrenergic receptor signalling pathway involved in positive regulation of heart rate" EXACT [GOC:bf]
synonym: "beta adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:mtg_cardiac_conduct_nov11]
synonym: "Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:mtg_cardiac_conduct_nov11]
synonym: "If activation by beta-adrenergic receptor signaling pathway" RELATED [GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0001996 ! positive regulation of heart rate by epinephrine-norepinephrine
is_a: GO:0071880 ! adenylate cyclase-activating adrenergic receptor signaling pathway
is_a: GO:0086023 ! adrenergic receptor signaling pathway involved in heart process
intersection_of: GO:0071875 ! adrenergic receptor signaling pathway
intersection_of: part_of GO:0010460 ! positive regulation of heart rate
relationship: has_part GO:0086010 ! membrane depolarization during action potential
relationship: part_of GO:0003062 ! regulation of heart rate by chemical signal
relationship: part_of GO:0010460 ! positive regulation of heart rate
created_by: tanyaberardini
creation_date: 2011-11-10T09:38:49Z

[Term]
id: GO:0086026
name: atrial cardiac muscle cell to AV node cell signaling
namespace: biological_process
def: "Any process that mediates the transfer of information from an atrial cardiomyocyte to an AV node cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "atrial cardiomyocyte to atrioventricular node cell signaling" EXACT []
synonym: "atrial cardiomyocyte to AV node cell signaling" EXACT []
synonym: "atrial cardiomyocyte to AV node cell signalling" EXACT [GOC:mah]
is_a: GO:0086019 ! cell-cell signaling involved in cardiac conduction
is_a: GO:0086066 ! atrial cardiac muscle cell to AV node cell communication
created_by: tanyaberardini
creation_date: 2011-11-11T02:02:14Z

[Term]
id: GO:0086027
name: AV node cell to bundle of His cell signaling
namespace: biological_process
def: "Any process that mediates the transfer of information from an AV node cardiac muscle cell to a bundle of His cardiomyocyte." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "atrioventricular node to bundle of His cell signaling" EXACT []
synonym: "AV node cell to bundle of His cell signalling" EXACT [GOC:mah]
is_a: GO:0086019 ! cell-cell signaling involved in cardiac conduction
is_a: GO:0086067 ! AV node cell to bundle of His cell communication
created_by: tanyaberardini
creation_date: 2011-11-11T02:02:14Z

[Term]
id: GO:0086028
name: bundle of His cell to Purkinje myocyte signaling
namespace: biological_process
def: "Any process that mediates the transfer of information from a bundle of His cardiomyocyte to a Purkinje myocyte." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "bundle of His cardiac muscle cell to Purkinje myocyte signaling" EXACT []
synonym: "bundle of His cardiac muscle cell to Purkinje myocyte signalling" EXACT [GOC:mah]
is_a: GO:0086019 ! cell-cell signaling involved in cardiac conduction
is_a: GO:0086069 ! bundle of His cell to Purkinje myocyte communication
created_by: tanyaberardini
creation_date: 2011-11-11T02:02:14Z

[Term]
id: GO:0086029
name: Purkinje myocyte to ventricular cardiac muscle cell signaling
namespace: biological_process
def: "Any process that mediates the transfer of information from a Purkinje myocyte to a ventricular cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "Purkinje myocyte to ventricular cardiac muscle cell signalling" EXACT [GOC:mah]
is_a: GO:0086019 ! cell-cell signaling involved in cardiac conduction
is_a: GO:0086068 ! Purkinje myocyte to ventricular cardiac muscle cell communication
created_by: tanyaberardini
creation_date: 2011-11-11T02:02:14Z

[Term]
id: GO:0086030
name: adrenergic receptor signaling pathway involved in cardiac muscle relaxation
namespace: biological_process
def: "An adrenergic receptor signaling pathway that contributes to a reduction in cardiac muscle contraction. Beta-adrenergic receptor-induced cardiac relaxation is achieved by a GPCR-activated adenylate cyclase generating cAMP; cAMP then activates the cAMP-dependent protein kinase A (PKA), which phosphorylates the sarcoplasmic reticulum (SR) membrane protein PLB. In its non-phosphorylated state, PLB acts as an inhibitor of the ATPase Ca(2+) pump of the cardiac SR (SERCA2a); inhibition of the pump is relieved upon phosphorylation. The pump removes Ca(2+) from the cytoplasm, thereby preventing cytosolic Ca(2+)-dependent activation of contractile proteins, leading to enhanced muscle relaxation." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:10571541]
synonym: "adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation" EXACT [GOC:mtg_cardiac_conduct_nov11]
synonym: "adrenergic receptor signaling pathway involved in cardiac muscle relaxation via activation of AC" RELATED [GOC:mtg_cardiac_conduct_nov11]
synonym: "adrenergic receptor-induced cardiac relaxation" RELATED [PMID:10571541]
synonym: "Gs-coupled adrenergic receptor signaling pathway involved in cardiac muscle relaxation" EXACT [GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0071880 ! adenylate cyclase-activating adrenergic receptor signaling pathway
is_a: GO:0086023 ! adrenergic receptor signaling pathway involved in heart process
intersection_of: GO:0071875 ! adrenergic receptor signaling pathway
intersection_of: part_of GO:0055119 ! relaxation of cardiac muscle
relationship: part_of GO:0055119 ! relaxation of cardiac muscle
created_by: tanyaberardini
creation_date: 2011-11-11T02:53:24Z

[Term]
id: GO:0086033
name: G-protein coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate
namespace: biological_process
def: "A G-protein coupled acetylcholine receptor signaling pathway that contributes to a decrease in frequency or rate of heart contraction. Binding of acetylcholine to a G-protein coupled (muscarinic) receptor on the surface of the signal-receiving cell results in the alpha subunit of a coupled G-protein binding to GTP. This results in the separation of the beta-gamma complex from the alpha subunit. Both the alpha subunit, and the beta-gamma complex can continue to signal to bring about membrane hyperpolarization and a reduction in heart rate." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, Wikipedia:G_protein-gated_ion_channel]
synonym: "M2 receptor signalling pathway involved in negative regulation of heart rate" EXACT []
synonym: "muscarinic acetylcholine receptor signaling pathway involved in negative regulation of heart rate" EXACT []
synonym: "muscarinic receptor signalling pathway involved in negative regulation of heart rate" EXACT []
is_a: GO:0086093 ! G-protein coupled acetylcholine receptor signaling pathway involved in heart process
intersection_of: GO:0007213 ! G-protein coupled acetylcholine receptor signaling pathway
intersection_of: part_of GO:0010459 ! negative regulation of heart rate
relationship: part_of GO:0003063 ! negative regulation of heart rate by acetylcholine
relationship: part_of GO:0010459 ! negative regulation of heart rate
created_by: tanyaberardini
creation_date: 2011-11-11T03:11:58Z

[Term]
id: GO:0086036
name: regulation of cardiac muscle cell membrane potential
namespace: biological_process
def: "Any process that modulates the establishment or extent of a membrane potential in a cardiac muscle cell (a cardiomyocyte). A membrane potential is the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0042391 ! regulation of membrane potential
created_by: tanyaberardini
creation_date: 2011-11-11T03:23:36Z

[Term]
id: GO:0086037
name: sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in), that contributes to regulating the membrane potential of a cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0005391 ! sodium:potassium-exchanging ATPase activity
intersection_of: GO:0005391 ! sodium:potassium-exchanging ATPase activity
intersection_of: part_of GO:0086036 ! regulation of cardiac muscle cell membrane potential
relationship: part_of GO:0086036 ! regulation of cardiac muscle cell membrane potential
created_by: tanyaberardini
creation_date: 2011-11-11T03:33:44Z

[Term]
id: GO:0086038
name: calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in), which contributes to regulating the membrane potential of a cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0005432 ! calcium:sodium antiporter activity
intersection_of: GO:0005432 ! calcium:sodium antiporter activity
intersection_of: part_of GO:0086036 ! regulation of cardiac muscle cell membrane potential
relationship: part_of GO:0086036 ! regulation of cardiac muscle cell membrane potential
created_by: tanyaberardini
creation_date: 2011-11-11T03:33:44Z

[Term]
id: GO:0086039
name: calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a cardiac muscle cell plasma membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). The transfer contributes to the regulation of the plasma membrane potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0005388 ! calcium-transporting ATPase activity
intersection_of: GO:0005388 ! calcium-transporting ATPase activity
intersection_of: part_of GO:0086036 ! regulation of cardiac muscle cell membrane potential
relationship: part_of GO:0086036 ! regulation of cardiac muscle cell membrane potential
created_by: tanyaberardini
creation_date: 2011-11-11T03:33:44Z

[Term]
id: GO:0086040
name: sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a cardiac muscle cell membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). This transfer contributes to the regulation of the cardiac muscle cell plasma membrane potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "sodium:hydrogen antiporter activity involved in regulation of cardiac muscle cell membrane potential" EXACT []
is_a: GO:0015385 ! sodium:proton antiporter activity
intersection_of: GO:0015385 ! sodium:proton antiporter activity
intersection_of: part_of GO:0086036 ! regulation of cardiac muscle cell membrane potential
relationship: part_of GO:0086036 ! regulation of cardiac muscle cell membrane potential
created_by: tanyaberardini
creation_date: 2011-11-11T03:33:44Z

[Term]
id: GO:0086041
name: voltage-gated potassium channel activity involved in SA node cell action potential depolarization
namespace: molecular_function
def: "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of an SA node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "voltage-gated potassium channel activity involved in SAN cell action potential depolarization" EXACT []
synonym: "voltage-gated potassium channel activity involved in sinoatrial node cell action potential depolarization" EXACT []
synonym: "voltage-gated potassium channel activity involved in sinus node cell action potential depolarization" NARROW []
is_a: GO:0005249 ! voltage-gated potassium channel activity
intersection_of: GO:0005267 ! potassium channel activity
intersection_of: part_of GO:0086046 ! membrane depolarization during SA node cell action potential
relationship: part_of GO:0086046 ! membrane depolarization during SA node cell action potential
created_by: tanyaberardini
creation_date: 2011-11-11T03:37:42Z

[Term]
id: GO:0086042
name: cardiac muscle cell-cardiac muscle cell adhesion
namespace: biological_process
def: "The attachment of one cardiomyocyte to another cardiomyocyte via adhesion molecules." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "cardiomyocyte-cardiomyocyte adhesion" EXACT []
is_a: GO:0034109 ! homotypic cell-cell adhesion
created_by: tanyaberardini
creation_date: 2011-11-11T04:06:25Z

[Term]
id: GO:0086043
name: bundle of His cell action potential
namespace: biological_process
def: "An action potential that occurs in a bundle of His cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "bundle of His cardiac muscle cell action potential" EXACT []
is_a: GO:0086001 ! cardiac muscle cell action potential
relationship: part_of GO:0086028 ! bundle of His cell to Purkinje myocyte signaling
created_by: dph
creation_date: 2011-11-15T12:01:18Z

[Term]
id: GO:0086044
name: atrial cardiac muscle cell to AV node cell communication by electrical coupling
namespace: biological_process
def: "The process that mediates signaling interactions between an atrial cardiomyocyte and an AV node cell by transfer of current between their adjacent cytoplasms via intercellular protein channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "atrial cardiomyocyte to atrioventricular node cell communication by electrical coupling" EXACT []
synonym: "atrial cardiomyocyte to AV node cell communication by electrical coupling" EXACT []
is_a: GO:0086064 ! cell communication by electrical coupling involved in cardiac conduction
is_a: GO:0086066 ! atrial cardiac muscle cell to AV node cell communication
created_by: dph
creation_date: 2011-11-15T02:51:29Z

[Term]
id: GO:0086045
name: membrane depolarization during AV node cell action potential
namespace: biological_process
def: "The process in which AV node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "membrane depolarization during atrioventricular node cardiac muscle cell action potential" EXACT []
synonym: "membrane depolarization during AV node cardiac muscle cell action potential" EXACT []
is_a: GO:0086012 ! membrane depolarization during cardiac muscle cell action potential
intersection_of: GO:0051899 ! membrane depolarization
intersection_of: part_of GO:0086016 ! AV node cell action potential
relationship: part_of GO:0086016 ! AV node cell action potential
created_by: dph
creation_date: 2011-11-16T10:45:18Z

[Term]
id: GO:0086046
name: membrane depolarization during SA node cell action potential
namespace: biological_process
def: "The process in which SA node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "membrane depolarization involved in regulation of SA node cardiac muscle cell action potential" EXACT []
synonym: "membrane depolarization involved in regulation of SAN cardiac muscle cell action potential" EXACT []
synonym: "membrane depolarization involved in regulation of sinoatrial node cardiac muscle cell action potential" EXACT []
synonym: "membrane depolarization involved in regulation of sinus node cardiac muscle cell action potential" NARROW []
is_a: GO:0086012 ! membrane depolarization during cardiac muscle cell action potential
intersection_of: GO:0051899 ! membrane depolarization
intersection_of: part_of GO:0086015 ! SA node cell action potential
relationship: part_of GO:0086015 ! SA node cell action potential
created_by: dph
creation_date: 2011-11-16T10:52:57Z

[Term]
id: GO:0086047
name: membrane depolarization during Purkinje myocyte cell action potential
namespace: biological_process
def: "The process in which Purkinje myocyte membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0086012 ! membrane depolarization during cardiac muscle cell action potential
intersection_of: GO:0051899 ! membrane depolarization
intersection_of: part_of GO:0086017 ! Purkinje myocyte action potential
relationship: part_of GO:0086017 ! Purkinje myocyte action potential
created_by: dph
creation_date: 2011-11-16T10:54:47Z

[Term]
id: GO:0086048
name: membrane depolarization during bundle of His cell action potential
namespace: biological_process
def: "The process in which bundle of His cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "membrane depolarization during bundle of His cardiac muscle cell action potential" EXACT []
is_a: GO:0086012 ! membrane depolarization during cardiac muscle cell action potential
intersection_of: GO:0051899 ! membrane depolarization
intersection_of: part_of GO:0086043 ! bundle of His cell action potential
relationship: part_of GO:0086043 ! bundle of His cell action potential
created_by: dph
creation_date: 2011-11-16T10:56:26Z

[Term]
id: GO:0086049
name: membrane repolarization during AV node cell action potential
namespace: biological_process
def: "The process in which ions are transported across a membrane such that the AV node cardiac muscle cell membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential." [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11]
synonym: "membrane repolarization involved in regulation of atrioventricular node cardiac muscle cell action potential" EXACT []
synonym: "membrane repolarization involved in regulation of AV node cardiac muscle cell action potential" EXACT []
is_a: GO:0086013 ! membrane repolarization during cardiac muscle cell action potential
intersection_of: GO:0086009 ! membrane repolarization
intersection_of: part_of GO:0086016 ! AV node cell action potential
relationship: part_of GO:0086016 ! AV node cell action potential
created_by: dph
creation_date: 2011-11-16T11:43:38Z

[Term]
id: GO:0086050
name: membrane repolarization during bundle of His cell action potential
namespace: biological_process
def: "The process in which ions are transported across a membrane such that the bundle of His cardiac muscle cell membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential." [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11]
synonym: "membrane repolarization during bundle of His cardiac muscle cell action potential" EXACT []
is_a: GO:0086013 ! membrane repolarization during cardiac muscle cell action potential
intersection_of: GO:0086009 ! membrane repolarization
intersection_of: part_of GO:0086043 ! bundle of His cell action potential
relationship: part_of GO:0086043 ! bundle of His cell action potential
created_by: dph
creation_date: 2011-11-16T11:50:41Z

[Term]
id: GO:0086051
name: membrane repolarization during Purkinje myocyte action potential
namespace: biological_process
def: "The process in which ions are transported across a membrane such that the Purkinje myocyte membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential." [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0086013 ! membrane repolarization during cardiac muscle cell action potential
intersection_of: GO:0086009 ! membrane repolarization
intersection_of: part_of GO:0086017 ! Purkinje myocyte action potential
relationship: part_of GO:0086017 ! Purkinje myocyte action potential
created_by: dph
creation_date: 2011-11-16T11:51:56Z

[Term]
id: GO:0086052
name: membrane repolarization during SA node cell action potential
namespace: biological_process
def: "The process in which an SA node cardiac muscle cell membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential." [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11]
synonym: "membrane repolarization involved in regulation of SA node cardiac muscle cell action potential" EXACT []
synonym: "membrane repolarization involved in regulation of SAN cardiac muscle cell action potential" EXACT []
synonym: "membrane repolarization involved in regulation of sinoatrial node cardiac muscle cell action potential" EXACT []
synonym: "membrane repolarization involved in regulation of sinus node cardiac muscle cell action potential" NARROW []
is_a: GO:0086013 ! membrane repolarization during cardiac muscle cell action potential
intersection_of: GO:0086009 ! membrane repolarization
intersection_of: part_of GO:0086015 ! SA node cell action potential
relationship: part_of GO:0086015 ! SA node cell action potential
created_by: dph
creation_date: 2011-11-16T11:54:12Z

[Term]
id: GO:0086053
name: AV node cell to bundle of His cell communication by electrical coupling
namespace: biological_process
def: "The process that mediates signaling interactions between an AV node cardiomyocyte and a bundle of His cardiac muscle cell by transfer of current between their adjacent cytoplasms via intercellular protein channels." [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11]
synonym: "atrioventricular node cell to bundle of His cell communication by electrical coupling" EXACT []
is_a: GO:0086064 ! cell communication by electrical coupling involved in cardiac conduction
is_a: GO:0086067 ! AV node cell to bundle of His cell communication
created_by: dph
creation_date: 2011-11-16T12:31:08Z

[Term]
id: GO:0086054
name: bundle of His cell to Purkinje myocyte communication by electrical coupling
namespace: biological_process
def: "The process that mediates signaling interactions between a bundle of His cardiac muscle cell and a Purkinje myocyte by transfer of current between their adjacent cytoplasms via intercellular protein channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "bundle of His cardiac muscle cell to Purkinje myocyte communication by electrical coupling" EXACT []
is_a: GO:0086064 ! cell communication by electrical coupling involved in cardiac conduction
is_a: GO:0086069 ! bundle of His cell to Purkinje myocyte communication
created_by: dph
creation_date: 2011-11-17T10:46:43Z

[Term]
id: GO:0086055
name: Purkinje myocyte to ventricular cardiac muscle cell communication by electrical coupling
namespace: biological_process
def: "The process that mediates signaling interactions between a Purkinje myocyte and a ventricular cardiac muscle cell by transfer of current between their adjacent cytoplasms via intercellular protein channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0086064 ! cell communication by electrical coupling involved in cardiac conduction
is_a: GO:0086068 ! Purkinje myocyte to ventricular cardiac muscle cell communication
created_by: dph
creation_date: 2011-11-17T10:51:59Z

[Term]
id: GO:0086056
name: voltage-gated calcium channel activity involved in AV node cell action potential
namespace: molecular_function
def: "Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an AV node cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "voltage-gated calcium channel activity involved in atrioventricular node cardiac muscle cell action potential" EXACT []
synonym: "voltage-gated calcium channel activity involved in AV node cardiac muscle cell action potential" EXACT []
is_a: GO:0086007 ! voltage-gated calcium channel activity involved in cardiac muscle cell action potential
intersection_of: GO:0005245 ! voltage-gated calcium channel activity
intersection_of: part_of GO:0086016 ! AV node cell action potential
relationship: part_of GO:0086016 ! AV node cell action potential
relationship: part_of GO:0086045 ! membrane depolarization during AV node cell action potential
created_by: dph
creation_date: 2011-11-17T12:24:22Z

[Term]
id: GO:0086057
name: voltage-gated calcium channel activity involved in bundle of His cell action potential
namespace: molecular_function
def: "Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of a bundle of His cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "voltage-gated calcium channel activity involved in bundle of His cardiac muscle cell action potential" EXACT []
is_a: GO:0086007 ! voltage-gated calcium channel activity involved in cardiac muscle cell action potential
intersection_of: GO:0005245 ! voltage-gated calcium channel activity
intersection_of: part_of GO:0086043 ! bundle of His cell action potential
relationship: part_of GO:0086043 ! bundle of His cell action potential
relationship: part_of GO:0086048 ! membrane depolarization during bundle of His cell action potential
created_by: dph
creation_date: 2011-11-17T12:32:51Z

[Term]
id: GO:0086058
name: voltage-gated calcium channel activity involved in Purkinje myocyte cell action potential
namespace: molecular_function
def: "Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an Purkinje myocyte cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0086007 ! voltage-gated calcium channel activity involved in cardiac muscle cell action potential
intersection_of: GO:0005245 ! voltage-gated calcium channel activity
intersection_of: part_of GO:0086017 ! Purkinje myocyte action potential
relationship: part_of GO:0086017 ! Purkinje myocyte action potential
relationship: part_of GO:0086047 ! membrane depolarization during Purkinje myocyte cell action potential
created_by: dph
creation_date: 2011-11-17T12:35:02Z

[Term]
id: GO:0086059
name: voltage-gated calcium channel activity involved SA node cell action potential
namespace: molecular_function
def: "Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an SA node cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "voltage-gated calcium channel activity involved in SA node cardiac muscle cell action potential" EXACT []
synonym: "voltage-gated calcium channel activity involved in SAN cardiac muscle cell action potential" EXACT []
synonym: "voltage-gated calcium channel activity involved in sinoatrial node cardiac muscle cell action potential" EXACT []
synonym: "voltage-gated calcium channel activity involved in sinus node cardiac muscle cell action potential" NARROW []
is_a: GO:0086007 ! voltage-gated calcium channel activity involved in cardiac muscle cell action potential
intersection_of: GO:0005245 ! voltage-gated calcium channel activity
intersection_of: part_of GO:0086015 ! SA node cell action potential
relationship: part_of GO:0086015 ! SA node cell action potential
relationship: part_of GO:0086046 ! membrane depolarization during SA node cell action potential
created_by: dph
creation_date: 2011-11-17T12:39:27Z

[Term]
id: GO:0086060
name: voltage-gated sodium channel activity involved in AV node cell action potential
namespace: molecular_function
def: "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of an AV node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "voltage-gated sodium channel activity involved in atrioventricular node cardiac muscle cell action potential" EXACT []
synonym: "voltage-gated sodium channel activity involved in AV node cardiac muscle cell action potential" EXACT []
is_a: GO:0086006 ! voltage-gated sodium channel activity involved in cardiac muscle cell action potential
intersection_of: GO:0005248 ! voltage-gated sodium channel activity
intersection_of: part_of GO:0086016 ! AV node cell action potential
relationship: part_of GO:0086016 ! AV node cell action potential
relationship: part_of GO:0086045 ! membrane depolarization during AV node cell action potential
created_by: dph
creation_date: 2011-11-17T12:52:48Z

[Term]
id: GO:0086061
name: voltage-gated sodium channel activity involved in bundle of His cell action potential
namespace: molecular_function
def: "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a bundle of His cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "voltage-gated sodium channel activity involved in bundle of His cardiac muscle cell action potential" EXACT []
is_a: GO:0086006 ! voltage-gated sodium channel activity involved in cardiac muscle cell action potential
intersection_of: GO:0005248 ! voltage-gated sodium channel activity
intersection_of: part_of GO:0086043 ! bundle of His cell action potential
relationship: part_of GO:0086043 ! bundle of His cell action potential
relationship: part_of GO:0086048 ! membrane depolarization during bundle of His cell action potential
created_by: dph
creation_date: 2011-11-17T12:58:13Z

[Term]
id: GO:0086062
name: voltage-gated sodium channel activity involved in Purkinje myocyte action potential
namespace: molecular_function
def: "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a Purkinje myocyte contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0086006 ! voltage-gated sodium channel activity involved in cardiac muscle cell action potential
intersection_of: GO:0005248 ! voltage-gated sodium channel activity
intersection_of: part_of GO:0086017 ! Purkinje myocyte action potential
relationship: part_of GO:0086017 ! Purkinje myocyte action potential
relationship: part_of GO:0086047 ! membrane depolarization during Purkinje myocyte cell action potential
created_by: dph
creation_date: 2011-11-17T01:50:43Z

[Term]
id: GO:0086063
name: voltage-gated sodium channel activity involved in SA node cell action potential
namespace: molecular_function
def: "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of an SA node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "voltage-gated sodium channel activity involved in SA node cardiac muscle cell action potential" EXACT []
synonym: "voltage-gated sodium channel activity involved in SAN cardiac muscle cell action potential" EXACT []
synonym: "voltage-gated sodium channel activity involved in sinoatrial node cardiac muscle cell action potential" EXACT []
synonym: "voltage-gated sodium channel activity involved in sinus node cardiac muscle cell action potential" NARROW []
is_a: GO:0086006 ! voltage-gated sodium channel activity involved in cardiac muscle cell action potential
intersection_of: GO:0005248 ! voltage-gated sodium channel activity
intersection_of: part_of GO:0086015 ! SA node cell action potential
relationship: part_of GO:0086015 ! SA node cell action potential
relationship: part_of GO:0086046 ! membrane depolarization during SA node cell action potential
created_by: dph
creation_date: 2011-11-17T01:53:08Z

[Term]
id: GO:0086064
name: cell communication by electrical coupling involved in cardiac conduction
namespace: biological_process
def: "The process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels and contributes to the process of cardiac conduction." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0010644 ! cell communication by electrical coupling
is_a: GO:0086065 ! cell communication involved in cardiac conduction
intersection_of: GO:0010644 ! cell communication by electrical coupling
intersection_of: part_of GO:0061337 ! cardiac conduction
relationship: part_of GO:0061337 ! cardiac conduction
created_by: dph
creation_date: 2011-11-22T08:49:44Z

[Term]
id: GO:0086065
name: cell communication involved in cardiac conduction
namespace: biological_process
def: "Any process that mediates interactions between a cell and its surroundings that contributes to the process of cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0007154 ! cell communication
intersection_of: GO:0007154 ! cell communication
intersection_of: part_of GO:0061337 ! cardiac conduction
relationship: part_of GO:0061337 ! cardiac conduction
created_by: dph
creation_date: 2011-11-22T08:57:02Z

[Term]
id: GO:0086066
name: atrial cardiac muscle cell to AV node cell communication
namespace: biological_process
def: "The process that mediates interactions between an atrial cardiomyocyte and its surroundings that contributes to the process of the atrial cardiomyocyte communicating with an AV node cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "atrial cardiomyocyte to atrioventricular node cell communication" EXACT []
synonym: "atrial cardiomyocyte to AV node cell communication" EXACT []
is_a: GO:0086065 ! cell communication involved in cardiac conduction
created_by: dph
creation_date: 2011-11-22T09:05:09Z

[Term]
id: GO:0086067
name: AV node cell to bundle of His cell communication
namespace: biological_process
def: "The process that mediates interactions between an AV node cell and its surroundings that contributes to the process of the AV node cell communicating with a bundle of His cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "atrioventricular node cell to bundle of His cell communication" EXACT []
is_a: GO:0086065 ! cell communication involved in cardiac conduction
created_by: dph
creation_date: 2011-11-22T09:11:44Z

[Term]
id: GO:0086068
name: Purkinje myocyte to ventricular cardiac muscle cell communication
namespace: biological_process
def: "The process that mediates interactions between a Purkinje myocyte and its surroundings that contributes to the process of the Purkinje myocyte communicating with a ventricular cardiac muscle cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0086065 ! cell communication involved in cardiac conduction
created_by: dph
creation_date: 2011-11-22T09:14:49Z

[Term]
id: GO:0086069
name: bundle of His cell to Purkinje myocyte communication
namespace: biological_process
def: "The process that mediates interactions between a bundle of His cell and its surroundings that contributes to the process of the bundle of His cell communicating with a Purkinje myocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "bundle of His cardiac muscle cell to Purkinje myocyte communication" EXACT []
is_a: GO:0086065 ! cell communication involved in cardiac conduction
created_by: dph
creation_date: 2011-11-22T09:18:49Z

[Term]
id: GO:0086070
name: SA node cell to atrial cardiac muscle cell communication
namespace: biological_process
def: "The process that mediates interactions between an SA node cardiomyocyte and its surroundings that contributes to the process of the SA node cardiomyocyte communicating with an atrial cardiomyocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "SA node cardiac muscle cell to atrial cardiac muscle cell communication" EXACT []
synonym: "SA node cardiomyocyte to atrial cardiomyocyte communication" EXACT []
synonym: "SAN cardiomyocyte to atrial cardiomyocyte communication" EXACT []
synonym: "sinoatrial node cardiomyocyte to atrial cardiomyocyte communication" EXACT []
synonym: "sinus node cardiomyocyte to atrial cardiomyocyte communication" NARROW []
is_a: GO:0086065 ! cell communication involved in cardiac conduction
created_by: dph
creation_date: 2011-11-22T09:32:45Z

[Term]
id: GO:0086071
name: atrial cardiac muscle cell-AV node cell adhesion involved in cell communication
namespace: biological_process
def: "The attachment of an atrial cardiomyocyte to an AV node cell via adhesion molecules that results in the cells being juxtaposed so that they can communicate." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "atrial cardiomyocyte-atrioventricular node cell adhesion involved in cell communication" EXACT []
synonym: "atrial cardiomyocyte-AV node cell adhesion involved in cell communication" EXACT []
is_a: GO:0034113 ! heterotypic cell-cell adhesion
is_a: GO:0086042 ! cardiac muscle cell-cardiac muscle cell adhesion
intersection_of: GO:0086042 ! cardiac muscle cell-cardiac muscle cell adhesion
intersection_of: part_of GO:0086066 ! atrial cardiac muscle cell to AV node cell communication
relationship: part_of GO:0086066 ! atrial cardiac muscle cell to AV node cell communication
created_by: dph
creation_date: 2011-11-22T09:46:33Z

[Term]
id: GO:0086072
name: AV node cell-bundle of His cell adhesion involved in cell communication
namespace: biological_process
def: "The attachment of an AV node cell to an bundle of His cell via adhesion molecules that results in the cells being juxtaposed so that they can communicate." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "atrioventricular node cell-bundle of His cell adhesion involved in cell communication" EXACT []
is_a: GO:0034113 ! heterotypic cell-cell adhesion
is_a: GO:0086042 ! cardiac muscle cell-cardiac muscle cell adhesion
relationship: part_of GO:0086067 ! AV node cell to bundle of His cell communication
created_by: dph
creation_date: 2011-11-22T09:49:59Z

[Term]
id: GO:0086073
name: bundle of His cell-Purkinje myocyte adhesion involved in cell communication
namespace: biological_process
def: "The attachment of a bundle of His cell to a Purkinje myocyte via adhesion molecules that results in the cells being juxtaposed so that they can communicate." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0034113 ! heterotypic cell-cell adhesion
is_a: GO:0086042 ! cardiac muscle cell-cardiac muscle cell adhesion
relationship: part_of GO:0086069 ! bundle of His cell to Purkinje myocyte communication
created_by: dph
creation_date: 2011-11-22T10:00:30Z

[Term]
id: GO:0086074
name: Purkinje myocyte-ventricular cardiac muscle cell adhesion involved in cell communication
namespace: biological_process
def: "The attachment of an Purkinje myocyte to a ventricular cardiac muscle cell via adhesion molecules that results in the cells being juxtaposed so that they can communicate." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0034113 ! heterotypic cell-cell adhesion
is_a: GO:0086042 ! cardiac muscle cell-cardiac muscle cell adhesion
relationship: part_of GO:0086068 ! Purkinje myocyte to ventricular cardiac muscle cell communication
created_by: dph
creation_date: 2011-11-22T10:02:24Z

[Term]
id: GO:0086075
name: gap junction channel activity involved in cardiac conduction electrical coupling
namespace: molecular_function
def: "A wide pore channel activity that enables a direct cytoplasmic connection from one cardiomyocyte to an adjacent cardiomyocyte. The gap junction passes electrical signals between the cells contributing to cardiac conduction." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:1903763 ! gap junction channel activity involved in cell communication by electrical coupling
intersection_of: GO:0005243 ! gap junction channel activity
intersection_of: part_of GO:0086064 ! cell communication by electrical coupling involved in cardiac conduction
relationship: part_of GO:0086064 ! cell communication by electrical coupling involved in cardiac conduction
created_by: dph
creation_date: 2011-11-22T10:08:29Z

[Term]
id: GO:0086076
name: gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling
namespace: molecular_function
def: "A wide pore channel activity that enables a direct cytoplasmic connection from an atrial cardiomyocyte to an AV node cell. The gap junction passes electrical signals between the cells contributing to cardiac conduction." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "gap junction channel activity involved in atrial cardiomyocyte-atrioventricular node cell electrical coupling" EXACT []
synonym: "gap junction channel activity involved in atrial cardiomyocyte-AV node cell electrical coupling" RELATED []
is_a: GO:0086075 ! gap junction channel activity involved in cardiac conduction electrical coupling
intersection_of: GO:0005243 ! gap junction channel activity
intersection_of: part_of GO:0086044 ! atrial cardiac muscle cell to AV node cell communication by electrical coupling
relationship: part_of GO:0086044 ! atrial cardiac muscle cell to AV node cell communication by electrical coupling
created_by: dph
creation_date: 2011-11-22T10:26:27Z

[Term]
id: GO:0086077
name: gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling
namespace: molecular_function
def: "A wide pore channel activity that enables a direct cytoplasmic connection from an AV node cell to a bundle of His cell. The gap junction passes electrical signals between the cells contributing to cardiac conduction." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "gap junction channel activity involved in atrioventricular node cell-bundle of His cell electrical coupling" EXACT []
is_a: GO:0086075 ! gap junction channel activity involved in cardiac conduction electrical coupling
intersection_of: GO:0005243 ! gap junction channel activity
intersection_of: part_of GO:0086053 ! AV node cell to bundle of His cell communication by electrical coupling
relationship: part_of GO:0086053 ! AV node cell to bundle of His cell communication by electrical coupling
created_by: dph
creation_date: 2011-11-22T10:29:53Z

[Term]
id: GO:0086078
name: gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling
namespace: molecular_function
def: "A wide pore channel activity that enables a direct cytoplasmic connection from a bundle of His cell to a Purkinje myocyte. The gap junction passes electrical signals between the cells contributing to cardiac conduction." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0086075 ! gap junction channel activity involved in cardiac conduction electrical coupling
intersection_of: GO:0005243 ! gap junction channel activity
intersection_of: part_of GO:0086054 ! bundle of His cell to Purkinje myocyte communication by electrical coupling
relationship: part_of GO:0086054 ! bundle of His cell to Purkinje myocyte communication by electrical coupling
created_by: dph
creation_date: 2011-11-22T10:34:13Z

[Term]
id: GO:0086079
name: gap junction channel activity involved in Purkinje myocyte-ventricular cardiac muscle cell electrical coupling
namespace: molecular_function
def: "A wide pore channel activity that enables a direct cytoplasmic connection from a Purkinje myocyte to a ventricular cardiac muscle cell. The gap junction passes electrical signals between the cells contributing to cardiac conduction." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0086075 ! gap junction channel activity involved in cardiac conduction electrical coupling
intersection_of: GO:0005243 ! gap junction channel activity
intersection_of: part_of GO:0086055 ! Purkinje myocyte to ventricular cardiac muscle cell communication by electrical coupling
relationship: part_of GO:0086055 ! Purkinje myocyte to ventricular cardiac muscle cell communication by electrical coupling
created_by: dph
creation_date: 2011-11-22T10:36:23Z

[Term]
id: GO:0086080
name: protein binding involved in heterotypic cell-cell adhesion
namespace: molecular_function
def: "Interacting selectively and non-covalently with any protein or protein complex contributing to the adhesion of two different types of cells." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0098632 ! protein binding involved in cell-cell adhesion
intersection_of: GO:0005515 ! protein binding
intersection_of: part_of GO:0034113 ! heterotypic cell-cell adhesion
relationship: part_of GO:0034113 ! heterotypic cell-cell adhesion
created_by: dph
creation_date: 2011-11-22T10:53:52Z

[Term]
id: GO:0086081
name: cell adhesive protein binding involved in atrial cardiac muscle cell-AV node cell communication
namespace: molecular_function
def: "Interacting selectively and non-covalently with any protein or protein complex that results in the connection of an atrial cardiomyocyte with an AV node cell and contributes to the communication between the two cells." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "cell adhesive protein binding involved in atrial cardiomyocyte-atrioventricular node cell communication" EXACT []
synonym: "cell adhesive protein binding involved in atrial cardiomyocyte-AV node cell communication" EXACT []
is_a: GO:0086080 ! protein binding involved in heterotypic cell-cell adhesion
intersection_of: GO:0086080 ! protein binding involved in heterotypic cell-cell adhesion
intersection_of: part_of GO:0086071 ! atrial cardiac muscle cell-AV node cell adhesion involved in cell communication
relationship: part_of GO:0086071 ! atrial cardiac muscle cell-AV node cell adhesion involved in cell communication
created_by: dph
creation_date: 2011-11-22T11:00:47Z

[Term]
id: GO:0086082
name: cell adhesive protein binding involved in AV node cell-bundle of His cell communication
namespace: molecular_function
def: "Interacting selectively and non-covalently with any protein or protein complex that results in the connection of an AV node cell with a bundle of His cell and contributes to the communication between the two cells." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "cell adhesive protein binding involved in atrioventricular node cell-bundle of His cell communication" EXACT []
is_a: GO:0086080 ! protein binding involved in heterotypic cell-cell adhesion
intersection_of: GO:0086080 ! protein binding involved in heterotypic cell-cell adhesion
intersection_of: part_of GO:0086072 ! AV node cell-bundle of His cell adhesion involved in cell communication
relationship: part_of GO:0086072 ! AV node cell-bundle of His cell adhesion involved in cell communication
created_by: dph
creation_date: 2011-11-22T11:09:37Z

[Term]
id: GO:0086083
name: cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication
namespace: molecular_function
def: "Interacting selectively and non-covalently with any protein or protein complex that results in the connection of a bundle of His cell with a Purkinje myocyte and contributes to the communication between the two cells." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0086080 ! protein binding involved in heterotypic cell-cell adhesion
intersection_of: GO:0086080 ! protein binding involved in heterotypic cell-cell adhesion
intersection_of: part_of GO:0086073 ! bundle of His cell-Purkinje myocyte adhesion involved in cell communication
relationship: part_of GO:0086073 ! bundle of His cell-Purkinje myocyte adhesion involved in cell communication
created_by: dph
creation_date: 2011-11-22T11:11:03Z

[Term]
id: GO:0086084
name: cell adhesive protein binding involved in Purkinje myocyte-ventricular cardiac muscle cell communication
namespace: molecular_function
def: "Interacting selectively and non-covalently with any protein or protein complex that results in the connection of a Purkinje myocyte with an ventricular cardiac muscle cell and contributes to the communication between the two cells." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0086080 ! protein binding involved in heterotypic cell-cell adhesion
intersection_of: GO:0086080 ! protein binding involved in heterotypic cell-cell adhesion
intersection_of: part_of GO:0086074 ! Purkinje myocyte-ventricular cardiac muscle cell adhesion involved in cell communication
relationship: part_of GO:0086074 ! Purkinje myocyte-ventricular cardiac muscle cell adhesion involved in cell communication
created_by: dph
creation_date: 2011-11-22T11:13:16Z

[Term]
id: GO:0086085
name: cell adhesive protein binding involved in SA cardiac muscle cell-atrial cardiac muscle cell communication
namespace: molecular_function
def: "Interacting selectively and non-covalently with any protein or protein complex that results in the connection of an SA cardiomyocyte with an atrial cardiomyocyte and contributes to the communication between the two cells." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "cell adhesive protein binding involved in SA cardiomyocyte-atrial cardiomyocyte communication" EXACT []
is_a: GO:0086080 ! protein binding involved in heterotypic cell-cell adhesion
intersection_of: GO:0086080 ! protein binding involved in heterotypic cell-cell adhesion
intersection_of: part_of GO:0086022 ! SA node cell-atrial cardiac muscle cell adhesion involved in cell communication
relationship: part_of GO:0086022 ! SA node cell-atrial cardiac muscle cell adhesion involved in cell communication
created_by: dph
creation_date: 2011-11-22T11:15:07Z

[Term]
id: GO:0086086
name: voltage-gated potassium channel activity involved in AV node cell action potential repolarization
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an AV node cardiac muscle cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "voltage-gated potassium channel activity involved in atrioventricular node cardiac muscle cell action potential" EXACT []
synonym: "voltage-gated potassium channel activity involved in AV node cardiac muscle cell action potential repolarization" EXACT []
is_a: GO:0086008 ! voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
relationship: part_of GO:0086016 ! AV node cell action potential
relationship: part_of GO:0086049 ! membrane repolarization during AV node cell action potential
created_by: dph
creation_date: 2011-11-22T01:26:32Z

[Term]
id: GO:0086087
name: voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization
namespace: molecular_function
def: "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a bundle of His cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0086008 ! voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
relationship: part_of GO:0086043 ! bundle of His cell action potential
relationship: part_of GO:0086050 ! membrane repolarization during bundle of His cell action potential
created_by: dph
creation_date: 2011-11-22T01:30:20Z

[Term]
id: GO:0086088
name: voltage-gated potassium channel activity involved in Purkinje myocyte action potential repolarization
namespace: molecular_function
def: "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a Purkinje myocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0086008 ! voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
relationship: part_of GO:0086017 ! Purkinje myocyte action potential
relationship: part_of GO:0086051 ! membrane repolarization during Purkinje myocyte action potential
created_by: dph
creation_date: 2011-11-22T01:32:02Z

[Term]
id: GO:0086089
name: voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
namespace: molecular_function
def: "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an atrial cardiomyocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization" EXACT []
is_a: GO:0086008 ! voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
relationship: part_of GO:0086014 ! atrial cardiac muscle cell action potential
created_by: dph
creation_date: 2011-11-22T01:33:01Z

[Term]
id: GO:0086090
name: voltage-gated potassium channel activity involved in SA node cell action potential repolarization
namespace: molecular_function
def: "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an SA node cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "voltage-gated potassium channel activity involved in SAN cell action potential" EXACT []
synonym: "voltage-gated potassium channel activity involved in sinoatrial node cell action potential" EXACT []
synonym: "voltage-gated potassium channel activity involved in sinus node cell action potential" NARROW []
is_a: GO:0086008 ! voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
relationship: part_of GO:0086052 ! membrane repolarization during SA node cell action potential
created_by: dph
creation_date: 2011-11-22T01:38:08Z

[Term]
id: GO:0086091
name: regulation of heart rate by cardiac conduction
namespace: biological_process
def: "A cardiac conduction process that modulates the frequency or rate of heart contraction." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0002027 ! regulation of heart rate
is_a: GO:0061337 ! cardiac conduction
created_by: dph
creation_date: 2011-11-29T01:04:19Z

[Term]
id: GO:0086092
name: regulation of the force of heart contraction by cardiac conduction
namespace: biological_process
def: "A cardiac conduction process that modulates the extent of heart contraction, changing the force with which blood is propelled." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0002026 ! regulation of the force of heart contraction
is_a: GO:0061337 ! cardiac conduction
created_by: dph
creation_date: 2011-11-29T01:26:41Z

[Term]
id: GO:0086093
name: G-protein coupled acetylcholine receptor signaling pathway involved in heart process
namespace: biological_process
def: "A G-protein coupled acetylcholine receptor signaling pathway, which contributes to a circulatory system process carried out by the heart." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "G-protein coupled acetylcholine receptor signalling pathway involved in heart process" RELATED [GOC:bf]
synonym: "M2 receptor signaling pathway involved in heart process" NARROW [GOC:mtg_cardiac_conduct_nov11]
synonym: "muscarinic receptor signaling pathway involved in heart process" RELATED [GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0007213 ! G-protein coupled acetylcholine receptor signaling pathway
is_a: GO:0086103 ! G-protein coupled receptor signaling pathway involved in heart process
intersection_of: GO:0007213 ! G-protein coupled acetylcholine receptor signaling pathway
intersection_of: part_of GO:0003015 ! heart process
relationship: part_of GO:0003015 ! heart process
created_by: rfoulger

[Term]
id: GO:0086094
name: positive regulation of ryanodine-sensitive calcium-release channel activity by adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction
namespace: biological_process
def: "An adrenergic receptor signaling pathway that contributes to an increase in frequency or rate of cardiac muscle contraction through phosphorylation and enhancement of the ryanodine receptor, a calcium-activated calcium-release channel found in the membrane of the sarcoplasmic reticulum. An adrenergic receptor-activated adenylate cyclase generates cAMP. cAMP then activates the cAMP-dependent protein kinase A (PKA), which phosphorylates the ryanodine receptor (RyR). PKA-phosphorylation of RyR enhances channel activity by sensitizing the channel to cytosolic calcium. Cytosolic calcium stimulates contractile proteins to promote muscle contraction." [GOC:bf, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:21099118]
synonym: "adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction via ryanodine receptor phosphorylation" NARROW [PMID:21099118]
is_a: GO:0060316 ! positive regulation of ryanodine-sensitive calcium-release channel activity
is_a: GO:0086023 ! adrenergic receptor signaling pathway involved in heart process
relationship: part_of GO:0003062 ! regulation of heart rate by chemical signal
relationship: part_of GO:0060452 ! positive regulation of cardiac muscle contraction
created_by: rfoulger

[Term]
id: GO:0086095
name: positive regulation of IKACh channel activity by G-protein coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate
namespace: biological_process
def: "A G-protein coupled acetylcholine receptor signaling pathway that contributes to a decrease in frequency or rate of heart contraction through activation of the IKACh potassium channel. Binding of acetylcholine to a G-protein coupled acetylcholine receptor (muscarinic receptor) on the surface of the signal-receiving cell results in liberation of the G-beta/gamma complex from the alpha subunit. The G-beta/gamma complex binds directly to the inward-rectifying potassium channel IKACh. Once the ion channel is activated, potassium ions (K+) flow out of the cell and cause it to hyperpolarize. In its hyperpolarized state, action potentials cannot be fired as quickly as possible, which slows the heart rate." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, Wikipedia:G_protein-gated_ion_channel]
synonym: "cardiac muscarinic receptor signaling via Gbeta/gamma" RELATED [GOC:mtg_cardiac_conduct_nov11]
synonym: "Gbeta/gamma-coupled muscarinic receptor signaling pathway involved in negative regulation of heart rate" RELATED [GOC:mtg_cardiac_conduct_nov11]
synonym: "muscarinic receptor signaling pathway involved in activation of IKACH" EXACT [GOC:mtg_cardiac_conduct_nov11]
synonym: "muscarinic receptor signaling pathway involved in ion channel activation" BROAD [GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0086033 ! G-protein coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate
is_a: GO:1900129 ! positive regulation of G-protein activated inward rectifier potassium channel activity
intersection_of: GO:0086033 ! G-protein coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate
intersection_of: positively_regulates GO:0015467 ! G-protein activated inward rectifier potassium channel activity
relationship: positively_regulates GO:0015467 ! G-protein activated inward rectifier potassium channel activity
created_by: rfoulger

[Term]
id: GO:0086096
name: adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process
namespace: biological_process
def: "An adrenergic receptor signaling pathway which contributes to a circulatory system process carried out by the heart, where the activated adrenergic receptor transmits the signal by Gi-mediated inhibition of adenylate cyclase activity." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:10571541]
comment: Although Beta1-adrenergic receptors couple exclusively to the Gs protein, Beta2-adrenergic receptors couple to both Gs and Gi proteins. Coupling to Gi proteins may localize the Gs-mediated signaling.
synonym: "cardiac adrenergic receptor signaling pathway via inhibition of adenylate cyclase activity" EXACT [GOC:bf]
synonym: "G-inhibitory-coupled Beta2AR signaling pathway involved in heart process" EXACT [PMID:17376402]
synonym: "Gi-coupled adrenergic receptor signaling pathway involved in heart process" EXACT [PMID:10571541]
synonym: "Gi-coupled Beta2-AR signaling pathway involved in heart process" EXACT [PMID:10571541]
is_a: GO:0071881 ! adenylate cyclase-inhibiting adrenergic receptor signaling pathway
is_a: GO:0086023 ! adrenergic receptor signaling pathway involved in heart process
intersection_of: GO:0071881 ! adenylate cyclase-inhibiting adrenergic receptor signaling pathway
intersection_of: part_of GO:0003015 ! heart process
relationship: part_of GO:0003015 ! heart process
created_by: rfoulger

[Term]
id: GO:0086097
name: phospholipase C-activating angiotensin-activated signaling pathway
namespace: biological_process
def: "An angiotensin-mediated signaling pathway where the activated receptor transmits the signal via Gq-mediated activation of phospholipase C (PLC). PLC hydrolyses phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers inositol-1,4,5,-triphosphate (IP3) and diacylglycerol (DAG). DAG activates protein kinase C (PKC), whilst IP3 binds intracellular receptors to induce the release of Ca2+ from intracellular stores." [GOC:bf, GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "angiotensin-mediated signaling pathway via activation of phospholipase C" EXACT [GOC:bf]
synonym: "Gq-coupled angiotensin receptor signaling pathway" EXACT [GOC:bf]
synonym: "phospholipase C-activating angiotensin receptor signaling pathway" EXACT [GOC:bf]
synonym: "phospholipase C-activating angiotensin-mediated signaling pathway" RELATED []
synonym: "PLC-activating angiotensin receptor signaling pathway" EXACT [GOC:bf]
is_a: GO:0007200 ! phospholipase C-activating G-protein coupled receptor signaling pathway
is_a: GO:0038166 ! angiotensin-activated signaling pathway
created_by: rfoulger
creation_date: 2012-06-13T11:28:15Z

[Term]
id: GO:0086098
name: angiotensin-activated signaling pathway involved in heart process
namespace: biological_process
def: "An angiotensin receptor signaling pathway which contributes to a circulatory system process carried out by the heart." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:17376402]
synonym: "angiotensin receptor signaling pathway involved in heart process" EXACT [GOC:bf]
synonym: "angiotensin receptor signalling pathway involved in heart process" EXACT [GOC:bf]
synonym: "angiotensin-mediated signaling pathway involved in heart process" RELATED []
is_a: GO:0038166 ! angiotensin-activated signaling pathway
is_a: GO:0086103 ! G-protein coupled receptor signaling pathway involved in heart process
intersection_of: GO:0038166 ! angiotensin-activated signaling pathway
intersection_of: part_of GO:0003015 ! heart process
relationship: part_of GO:0003015 ! heart process
created_by: rfoulger

[Term]
id: GO:0086099
name: phospholipase C-activating angiotensin-activated signaling pathway involved in heart process
namespace: biological_process
def: "An angiotensin-mediated signaling pathway that contributes to a circulatory system process carried out by the heart, where the activated receptor transmits the signal via Gq-mediated activation of phospholipase C (PLC). PLC hydrolyses phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers inositol-1,4,5,-triphosphate (IP3) and diacylglycerol (DAG). DAG activates protein kinase C (PKC), whilst IP3 binds intracellular receptors to induce the release of Ca2+ from intracellular stores." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:17376402]
synonym: "angiotensin receptor signaling pathway via activation of phospholipase C involved in heart process" EXACT [GOC:bf]
synonym: "cardiac angiotensin receptor signaling pathway via activation of PLC" EXACT [GOC:bf]
synonym: "Gq-coupled angiotensin receptor signaling pathway involved in heart process" EXACT [PMID:17376402]
synonym: "phospholipase C-activating angiotensin-mediated signaling pathway involved in heart process" RELATED []
synonym: "PLC-activating angiotensin receptor signaling pathway involved in heart process" EXACT [GOC:bf]
is_a: GO:0086097 ! phospholipase C-activating angiotensin-activated signaling pathway
is_a: GO:0086098 ! angiotensin-activated signaling pathway involved in heart process
intersection_of: GO:0086097 ! phospholipase C-activating angiotensin-activated signaling pathway
intersection_of: part_of GO:0003015 ! heart process
relationship: part_of GO:0003015 ! heart process
created_by: rfoulger

[Term]
id: GO:0086100
name: endothelin receptor signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by an endothelin receptor binding to one of its physiological ligands, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. Ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:10977869]
synonym: "endothelin signaling pathway" RELATED [GOC:bf]
is_a: GO:0007186 ! G-protein coupled receptor signaling pathway
created_by: rfoulger

[Term]
id: GO:0086101
name: endothelin receptor signaling pathway involved in heart process
namespace: biological_process
def: "An endothelin receptor signaling pathway which contributes to a circulatory system process carried out by the heart." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:17376402]
synonym: "endothelin receptor signalling pathway involved in heart process" EXACT [GOC:bf]
is_a: GO:0086100 ! endothelin receptor signaling pathway
is_a: GO:0086103 ! G-protein coupled receptor signaling pathway involved in heart process
intersection_of: GO:0086100 ! endothelin receptor signaling pathway
intersection_of: part_of GO:0003015 ! heart process
relationship: part_of GO:0003015 ! heart process
created_by: rfoulger

[Term]
id: GO:0086102
name: adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate
namespace: biological_process
def: "A G-protein coupled acetylcholine receptor signaling pathway that contributes to an decrease in frequency or rate of heart contraction through inhibition of adenylate cyclase (AC) activity. Binding of acetylcholine to a G-protein coupled (muscarinic) receptor on the surface of the signal-receiving cell results in the activation of an intracellular Gi/o protein. Gi/o inhibits adenylate cyclase to decrease cyclic-AMP (cAMP) levels. Since cAMP binds directly to F-channels to allow an inward flow of sodium (funny current, If current), a reduction in cAMP reduces the funny current to bring about membrane hyperpolarization and a decrease in heart rate." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "AC-inhibiting muscarinic receptor signaling pathway involved in negative regulation of heart rate" RELATED [GOC:bf]
synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate via inhibition of adenylate cyclase activity" EXACT [GOC:bf]
synonym: "Gi-coupled G-protein coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate" BROAD [GOC:bf]
synonym: "muscarinic receptor signalling pathway involved in negative regulation of heart rate by inhibition of funny current" EXACT [GOC:mtg_cardiac_conduct_nov11]
synonym: "muscarinic receptor signalling pathway involved in negative regulation of heart rate by inhibition of If channel" EXACT [GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0007197 ! adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
is_a: GO:0086033 ! G-protein coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate
intersection_of: GO:0007197 ! adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
intersection_of: part_of GO:0010459 ! negative regulation of heart rate
relationship: part_of GO:0010459 ! negative regulation of heart rate
created_by: rfoulger

[Term]
id: GO:0086103
name: G-protein coupled receptor signaling pathway involved in heart process
namespace: biological_process
def: "An G-protein coupled receptor signaling pathway which contributes to a circulatory system process carried out by the heart." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:17376402]
synonym: "G-protein coupled receptor signalling pathway involved in heart process" EXACT [GOC:bf]
synonym: "GPCR signaling pathway involved in cardiac process" EXACT [GOC:bf]
synonym: "GPCR signaling pathway involved in heart process" EXACT [GOC:bf]
is_a: GO:0007186 ! G-protein coupled receptor signaling pathway
intersection_of: GO:0007186 ! G-protein coupled receptor signaling pathway
intersection_of: part_of GO:0003015 ! heart process
relationship: part_of GO:0003015 ! heart process
created_by: rfoulger
creation_date: 2012-03-19T01:28:23Z

[Term]
id: GO:0089700
name: protein kinase D signaling
namespace: biological_process
def: "A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase D, which occurs as a result of a single trigger reaction or compound." [GOC:BHF, GOC:dos, GOC:mah]
synonym: "PKD signal transduction" EXACT [GOC:signaling]
synonym: "PKD signaling cascade" RELATED [GOC:mah]
synonym: "protein kinase D signal transduction" EXACT [GOC:signaling]
synonym: "protein kinase D signaling cascade" RELATED [GOC:signaling]
synonym: "protein kinase D signalling cascade" RELATED [GOC:mah]
is_a: GO:0035556 ! intracellular signal transduction

[Term]
id: GO:0089701
name: U2AF
namespace: cellular_component
def: "A heterodimeric protein complex consisting of conserved large and small U2AF subunits that contributes to spliceosomal RNA splicing by binding to consensus sequences at the 3' splice site. U2AF is required to stabilize the association of the U2 snRNP with the branch point." [GOC:dos, GOC:mah, PMID:15231733, PMID:1538748, PMID:2963698, PMID:8657565]
synonym: "U2 accessory factor" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0005634 ! nucleus

[Term]
id: GO:0089702
name: undecaprenyl-phosphate glucose phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + ditrans,octacis-undecaprenyl phosphate = UMP + alpha-D-glucopyranosyl-diphospho-ditrans,octacis-undecaprenol." [EC:2.7.8.31, GOC:dos, GOC:imk]
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0089703
name: L-aspartate transmembrane export from vacuole
namespace: biological_process
def: "The directed movement of L-aspartate out of the vacuole, across the vacuolar membrane." [PMID:21307582]
is_a: GO:0032974 ! amino acid transmembrane export from vacuole
is_a: GO:0089712 ! L-aspartate transmembrane transport

[Term]
id: GO:0089704
name: L-glutamate transmembrane export from vacuole
namespace: biological_process
def: "The directed movement of L-glutamate out of the vacuole, across the vacuolar membrane." [PMID:21307582]
is_a: GO:0032974 ! amino acid transmembrane export from vacuole
is_a: GO:0089711 ! L-glutamate transmembrane transport

[Term]
id: GO:0089705
name: protein localization to outer membrane
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a specific location the cell outer membrane." [GOC:dos, PMID:12823819]
is_a: GO:0072657 ! protein localization to membrane
is_a: GO:1990778 ! protein localization to cell periphery

[Term]
id: GO:0089706
name: L-ornithine transmembrane export from vacuole
namespace: biological_process
def: "The directed movement of L-ornithine out of the vacuole, across the vacuolar membrane." [PMID:21307582]
is_a: GO:0032974 ! amino acid transmembrane export from vacuole
is_a: GO:1903352 ! L-ornithine transmembrane transport

[Term]
id: GO:0089707
name: L-lysine transmembrane export from vacuole
namespace: biological_process
def: "The directed movement of L-lysine out of the vacuole, across the vacuolar membrane." [PMID:21307582]
is_a: GO:0034488 ! basic amino acid transmembrane export from vacuole
is_a: GO:1903401 ! L-lysine transmembrane transport

[Term]
id: GO:0089708
name: L-histidine transmembrane export from vacuole
namespace: biological_process
def: "The directed movement of L-histidine out of the vacuole, across the vacuolar membrane." [PMID:21307582]
is_a: GO:0034488 ! basic amino acid transmembrane export from vacuole
is_a: GO:0089709 ! L-histidine transmembrane transport

[Term]
id: GO:0089709
name: L-histidine transmembrane transport
namespace: biological_process
def: "The directed movement of L-histidine across a membrane." [PMID:21307582]
is_a: GO:0098655 ! cation transmembrane transport
is_a: GO:1902024 ! L-histidine transport
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport

[Term]
id: GO:0089710
name: endocytic targeting sequence binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a endocytic signal sequence, a specific peptide sequence, of 4-6 amino acids with an essential tyrosine (Y), found on cytoplasmic tails of some cell surface membrane proteins, which directs internalization by clathrin-coated pits." [PMID:8918456]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0089711
name: L-glutamate transmembrane transport
namespace: biological_process
def: "The directed movement of L-glutamate across a membrane." [PMID:21307582]
is_a: GO:0015813 ! L-glutamate transport
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport

[Term]
id: GO:0089712
name: L-aspartate transmembrane transport
namespace: biological_process
def: "The directed movement of L-aspartate across a membrane." [PMID:21307582]
is_a: GO:0070778 ! L-aspartate transport
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport

[Term]
id: GO:0089713
name: Cbf1-Met4-Met28 complex
namespace: cellular_component
def: "A heteromeric complex consisting of Cbf1 and basic leucine zipper (bZIP) containing transcriptional activators, Met4 and Met28, that forms over the sequence TCACGTG in the upstream activating sequence (UAS) of genes involved in sulfur amino acid metabolism, resulting in their transcriptional activation." [PMID:8665859, PMID:9171357]
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0089714
name: UDP-N-acetyl-D-mannosamine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-alpha-D-mannosamine + 2 NAD+ + H2O = UDP-N-acetyl-alpha-D-mannosaminuronate + 2 NADH + 2 H+." [EC:1.1.1.336]
xref: EC:1.1.1.336
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0089715
name: tRNA m6t6A37 methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing N6-threonylcarbamoyladenosine = S-adenosyl-L-homocysteine + tRNA containing N6-methylthreonylcarbamoyladenosine." [PMID:25063302]
comment: This activity is distinct from from 'tRNA (adenine-N6-)-methyltransferase activity' (GO:0016430) in that it requires the presence of a threonylcarbamoyl modification.
is_a: GO:0016426 ! tRNA (adenine) methyltransferase activity

[Term]
id: GO:0089716
name: Pip2-Oaf1 complex
namespace: cellular_component
def: "A heterodimeric complex consisting of Zn(2)Cys(6) containing transcription factors Pip2 and Oaf1. It binds to the oleate response element (ORE), found in the promoters of fatty acid-inducible genes in Saccharomyces where, in the presence of oleate this bound complex activates the transcription of genes encoding peroxisomal proteins." [PMID:8972187, PMID:9288897]
is_a: GO:0090575 ! RNA polymerase II transcription factor complex

[Term]
id: GO:0089717
name: spanning component of membrane
namespace: cellular_component
def: "The component of a membrane consisting of gene products and protein complexes that have some part that spans both leaflets of the membrane." [GOC:dos]
is_a: GO:0016021 ! integral component of membrane

[Term]
id: GO:0089718
name: amino acid import across plasma membrane
namespace: biological_process
def: "The directed movement of an amino acid from outside of a cell, across the plasma membrane and into the cytosol." [GOC:krc, PMID:8195186]
is_a: GO:0003333 ! amino acid transmembrane transport
is_a: GO:0098739 ! import across plasma membrane
is_a: GO:1902837 ! amino acid import into cell

[Term]
id: GO:0089719
name: RHG protein domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RHG (reaper/hid/grimm) domain/motif (AKA iap binding motif)." [GOC:dos, GOC:ha]
synonym: "iap binding domain binding" EXACT []
synonym: "inhibitor of apoptosis binding domain binding" EXACT []
synonym: "reaper hid grim domain binding" EXACT []
synonym: "RHG domain binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0089720
name: caspase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a caspase family protein." [GOC:dos, GOC:ha]
is_a: GO:0002020 ! protease binding

[Term]
id: GO:0089721
name: phosphoenolpyruvate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a phosphoenolpyruvate from one side of a membrane to the other." [GOC:dos]
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity
relationship: part_of GO:0089722 ! phosphoenolpyruvate transmembrane transport

[Term]
id: GO:0089722
name: phosphoenolpyruvate transmembrane transport
namespace: biological_process
def: "The directed movement of phosphoenolpytuvate across a membrane." [GOC:dos]
is_a: GO:0015714 ! phosphoenolpyruvate transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport

[Term]
id: GO:0090001
name: replication fork arrest at tRNA locus
namespace: biological_process
def: "A process that impedes the progress of the DNA replication fork at natural replication fork pausing sites within the eukaryotic tRNA transcription unit." [GOC:dph, GOC:tb]
is_a: GO:0043111 ! replication fork arrest
created_by: tanyaberardini
creation_date: 2009-06-24T11:36:15Z

[Term]
id: GO:0090002
name: establishment of protein localization to plasma membrane
namespace: biological_process
def: "The directed movement of a protein to a specific location in the plasma membrane." [GOC:dph, GOC:tb]
synonym: "establishment of protein localisation in plasma membrane" EXACT [GOC:mah]
synonym: "establishment of protein localization in plasma membrane" EXACT [GOC:curators]
is_a: GO:0090150 ! establishment of protein localization to membrane
relationship: part_of GO:0072659 ! protein localization to plasma membrane
created_by: tanyaberardini
creation_date: 2009-07-10T10:29:23Z

[Term]
id: GO:0090003
name: regulation of establishment of protein localization to plasma membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location in the plasma membrane." [GOC:dph, GOC:tb]
synonym: "regulation of establishment of protein localisation in plasma membrane" EXACT [GOC:mah]
synonym: "regulation of establishment of protein localization in plasma membrane" EXACT [GOC:curators]
is_a: GO:0070201 ! regulation of establishment of protein localization
is_a: GO:1903076 ! regulation of protein localization to plasma membrane
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0090002 ! establishment of protein localization to plasma membrane
relationship: regulates GO:0090002 ! establishment of protein localization to plasma membrane
created_by: tanyaberardini
creation_date: 2009-07-10T10:32:44Z

[Term]
id: GO:0090004
name: positive regulation of establishment of protein localization to plasma membrane
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the directed movement of a protein to a specific location in the plasma membrane." [GOC:dph, GOC:tb]
synonym: "positive regulation of establishment of protein localisation in plasma membrane" EXACT [GOC:mah]
synonym: "positive regulation of establishment of protein localization in plasma membrane" EXACT [GOC:curators]
is_a: GO:0090003 ! regulation of establishment of protein localization to plasma membrane
is_a: GO:1903078 ! positive regulation of protein localization to plasma membrane
is_a: GO:1904951 ! positive regulation of establishment of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0090002 ! establishment of protein localization to plasma membrane
relationship: positively_regulates GO:0090002 ! establishment of protein localization to plasma membrane
created_by: tanyaberardini
creation_date: 2009-07-10T10:34:17Z

[Term]
id: GO:0090005
name: negative regulation of establishment of protein localization to plasma membrane
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the directed movement of a protein to a specific location in the plasma membrane." [GOC:dph, GOC:tb]
synonym: "negative regulation of establishment of protein localisation in plasma membrane" EXACT [GOC:mah]
synonym: "negative regulation of establishment of protein localization in plasma membrane" EXACT [GOC:curators]
is_a: GO:0090003 ! regulation of establishment of protein localization to plasma membrane
is_a: GO:1903077 ! negative regulation of protein localization to plasma membrane
is_a: GO:1904950 ! negative regulation of establishment of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0090002 ! establishment of protein localization to plasma membrane
relationship: negatively_regulates GO:0090002 ! establishment of protein localization to plasma membrane
created_by: tanyaberardini
creation_date: 2009-07-10T10:35:55Z

[Term]
id: GO:0090006
name: regulation of linear element assembly
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of linear element assembly. Linear element assembly is the cell cycle process in which a proteinaceous scaffold, related to the synaptonemal complex, is assembled in association with S. pombe chromosomes during meiotic prophase." [GOC:tb]
synonym: "regulation of linear element assembly" RELATED [GOC:dph]
is_a: GO:0033044 ! regulation of chromosome organization
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0060629 ! regulation of homologous chromosome segregation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030999 ! linear element assembly
relationship: regulates GO:0030999 ! linear element assembly
created_by: tanyaberardini
creation_date: 2009-07-17T01:05:13Z

[Term]
id: GO:0090007
name: obsolete regulation of mitotic anaphase
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of mitotic anaphase, a cell cycle process comprising the steps by which a cell progresses through anaphase, the stage of mitosis during which the two sets of chromosomes separate and move away from each other." [GOC:tb]
comment: This term was made obsolete as part of the cell cycle overhaul. This is because it was decided that cell cycle phases are intervals and so cannot be regulated, rather it is the transitions between the phases that are regulated.
synonym: "regulation of mitotic anaphase" EXACT []
is_obsolete: true
created_by: tanyaberardini
creation_date: 2009-07-17T01:08:58Z

[Term]
id: GO:0090008
name: hypoblast development
namespace: biological_process
def: "The process whose specific outcome is the progression of the hypoblast over time, from its formation to the mature structure. The hypoblast is a tissue formed from the inner cell mass that lies beneath the epiblast and gives rise to extraembryonic endoderm." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0009888 ! tissue development
created_by: tanyaberardini
creation_date: 2009-07-29T10:25:54Z

[Term]
id: GO:0090009
name: primitive streak formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the primitive streak from unspecified parts. The primitive streak is a ridge of cells running along the midline of the embryo where the mesoderm ingresses. It defines the anterior-posterior axis." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0001702 ! gastrulation with mouth forming second
relationship: part_of GO:0009948 ! anterior/posterior axis specification
created_by: tanyaberardini
creation_date: 2009-07-29T10:31:31Z

[Term]
id: GO:0090010
name: transforming growth factor beta receptor signaling pathway involved in primitive streak formation
namespace: biological_process
def: "A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, which contributes to the formation of the primitive streak." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "TGFbeta signaling pathway involved in primitive streak formation" RELATED [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "transforming growth factor beta receptor signalling pathway involved in primitive streak formation" EXACT [GOC:mah]
is_a: GO:0007179 ! transforming growth factor beta receptor signaling pathway
intersection_of: GO:0007179 ! transforming growth factor beta receptor signaling pathway
intersection_of: part_of GO:0090009 ! primitive streak formation
relationship: part_of GO:0090009 ! primitive streak formation
created_by: tanyaberardini
creation_date: 2009-07-29T10:38:40Z

[Term]
id: GO:0090011
name: Wnt signaling pathway involved in primitive streak formation
namespace: biological_process
def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in transcription of target genes that contribute to the formation of the primitive streak." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "Wnt receptor signaling pathway involved in primitive streak formation" EXACT []
synonym: "Wnt receptor signalling pathway involved in primitive streak formation" EXACT [GOC:mah]
synonym: "Wnt-activated signaling pathway involved in primitive streak formation" EXACT [GOC:signaling]
is_a: GO:0044333 ! Wnt signaling pathway involved in digestive tract morphogenesis
intersection_of: GO:0016055 ! Wnt signaling pathway
intersection_of: part_of GO:0090009 ! primitive streak formation
relationship: part_of GO:0090009 ! primitive streak formation
created_by: tanyaberardini
creation_date: 2009-07-29T10:44:53Z

[Term]
id: GO:0090012
name: negative regulation of transforming growth factor beta receptor signaling pathway involved in primitive streak formation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway that contributes to the formation of the primitive streak." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "negative regulation of transforming growth factor beta receptor signalling pathway involved in primitive streak formation" EXACT [GOC:mah]
is_a: GO:0030512 ! negative regulation of transforming growth factor beta receptor signaling pathway
is_a: GO:0090013 ! regulation of transforming growth factor beta receptor signaling pathway involved in primitive streak formation
is_a: GO:2000542 ! negative regulation of gastrulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0090010 ! transforming growth factor beta receptor signaling pathway involved in primitive streak formation
relationship: negatively_regulates GO:0090010 ! transforming growth factor beta receptor signaling pathway involved in primitive streak formation
created_by: tanyaberardini
creation_date: 2009-07-29T10:51:57Z

[Term]
id: GO:0090013
name: regulation of transforming growth factor beta receptor signaling pathway involved in primitive streak formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of any TGF-beta receptor signaling pathway that contributes to the formation of the primitive streak." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "regulation of transforming growth factor beta receptor signalling pathway involved in primitive streak formation" EXACT [GOC:mah]
is_a: GO:0010470 ! regulation of gastrulation
is_a: GO:0017015 ! regulation of transforming growth factor beta receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0090010 ! transforming growth factor beta receptor signaling pathway involved in primitive streak formation
relationship: regulates GO:0090010 ! transforming growth factor beta receptor signaling pathway involved in primitive streak formation
created_by: tanyaberardini
creation_date: 2009-07-29T10:54:44Z

[Term]
id: GO:0090014
name: leaflet formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a leaflet from unspecified parts. A leaflet is one of the ultimate segments of a compound leaf." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0060794 ! leaflet morphogenesis
created_by: tanyaberardini
creation_date: 2009-07-29T11:05:37Z

[Term]
id: GO:0090015
name: positive regulation of leaflet formation by auxin mediated signaling pathway
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of leaflet formation as a result of the series of molecular signals generated in response to detection of auxin." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "positive regulation of leaflet formation by auxin mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0009734 ! auxin-activated signaling pathway
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0090016 ! regulation of leaflet formation
relationship: positively_regulates GO:0090014 ! leaflet formation
created_by: tanyaberardini
creation_date: 2009-07-29T11:18:45Z

[Term]
id: GO:0090016
name: regulation of leaflet formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of leaflet formation." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:1901371 ! regulation of leaf morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0090014 ! leaflet formation
relationship: regulates GO:0090014 ! leaflet formation
created_by: tanyaberardini
creation_date: 2009-07-29T11:23:48Z

[Term]
id: GO:0090017
name: anterior neural plate formation
namespace: biological_process
def: "The formation of anterior end of the flat, thickened layer of ectodermal cells known as the neural plate." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021990 ! neural plate formation
created_by: tanyaberardini
creation_date: 2009-07-29T11:31:35Z

[Term]
id: GO:0090018
name: posterior neural plate formation
namespace: biological_process
def: "The formation of posterior end of the flat, thickened layer of ectodermal cells known as the neural plate." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021990 ! neural plate formation
created_by: tanyaberardini
creation_date: 2009-07-29T11:32:08Z

[Term]
id: GO:0090019
name: regulation of transcription involved in anterior neural plate formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter contributing to the formation of the anterior neural plate." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
intersection_of: part_of GO:0090017 ! anterior neural plate formation
relationship: part_of GO:0090017 ! anterior neural plate formation
created_by: tanyaberardini
creation_date: 2009-07-29T11:38:28Z

[Term]
id: GO:0090020
name: regulation of transcription involved in posterior neural plate formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter contributing to the formation of the posterior neural plate." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
intersection_of: part_of GO:0090018 ! posterior neural plate formation
relationship: part_of GO:0090018 ! posterior neural plate formation
created_by: tanyaberardini
creation_date: 2009-07-29T11:39:29Z

[Term]
id: GO:0090021
name: positive regulation of posterior neural plate formation by Wnt signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and increasing the rate or extent of posterior neural plate formation." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "positive regulation of posterior neural plate formation by Wnt receptor signaling pathway" EXACT []
synonym: "positive regulation of posterior neural plate formation by Wnt receptor signalling pathway" EXACT [GOC:mah]
synonym: "positive regulation of posterior neural plate formation by Wnt-activated signaling pathway" EXACT [GOC:signaling]
is_a: GO:0016055 ! Wnt signaling pathway
is_a: GO:0040019 ! positive regulation of embryonic development
is_a: GO:2000027 ! regulation of organ morphogenesis
relationship: positively_regulates GO:0090018 ! posterior neural plate formation
created_by: tanyaberardini
creation_date: 2009-07-29T11:44:13Z

[Term]
id: GO:0090022
name: regulation of neutrophil chemotaxis
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding." [GOC:dph, GOC:tb]
is_a: GO:0071622 ! regulation of granulocyte chemotaxis
is_a: GO:1902622 ! regulation of neutrophil migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030593 ! neutrophil chemotaxis
relationship: regulates GO:0030593 ! neutrophil chemotaxis
created_by: tanyaberardini
creation_date: 2009-08-03T10:09:34Z

[Term]
id: GO:0090023
name: positive regulation of neutrophil chemotaxis
namespace: biological_process
def: "Any process that increases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding." [GOC:dph, GOC:tb]
is_a: GO:0071624 ! positive regulation of granulocyte chemotaxis
is_a: GO:0090022 ! regulation of neutrophil chemotaxis
is_a: GO:1902624 ! positive regulation of neutrophil migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030593 ! neutrophil chemotaxis
relationship: positively_regulates GO:0030593 ! neutrophil chemotaxis
created_by: tanyaberardini
creation_date: 2009-08-03T10:12:23Z

[Term]
id: GO:0090024
name: negative regulation of neutrophil chemotaxis
namespace: biological_process
def: "Any process that decreases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding." [GOC:dph, GOC:tb]
is_a: GO:0071623 ! negative regulation of granulocyte chemotaxis
is_a: GO:0090022 ! regulation of neutrophil chemotaxis
is_a: GO:1902623 ! negative regulation of neutrophil migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030593 ! neutrophil chemotaxis
relationship: negatively_regulates GO:0030593 ! neutrophil chemotaxis
created_by: tanyaberardini
creation_date: 2009-08-03T10:13:09Z

[Term]
id: GO:0090025
name: regulation of monocyte chemotaxis
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of monocyte chemotaxis." [GOC:dph, GOC:tb]
is_a: GO:0002688 ! regulation of leukocyte chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002548 ! monocyte chemotaxis
relationship: regulates GO:0002548 ! monocyte chemotaxis
created_by: tanyaberardini
creation_date: 2009-08-03T10:17:03Z

[Term]
id: GO:0090026
name: positive regulation of monocyte chemotaxis
namespace: biological_process
def: "Any process that increases the frequency, rate, or extent of monocyte chemotaxis." [GOC:dph, GOC:tb]
is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis
is_a: GO:0090025 ! regulation of monocyte chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002548 ! monocyte chemotaxis
relationship: positively_regulates GO:0002548 ! monocyte chemotaxis
created_by: tanyaberardini
creation_date: 2009-08-03T10:18:54Z

[Term]
id: GO:0090027
name: negative regulation of monocyte chemotaxis
namespace: biological_process
def: "Any process that decreases the frequency, rate, or extent of monocyte chemotaxis." [GOC:dph, GOC:tb]
is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis
is_a: GO:0090025 ! regulation of monocyte chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002548 ! monocyte chemotaxis
relationship: negatively_regulates GO:0002548 ! monocyte chemotaxis
created_by: tanyaberardini
creation_date: 2009-08-03T10:19:40Z

[Term]
id: GO:0090028
name: positive regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of pheromone-dependent signal transduction during conjugation with cellular fusion, a signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion." [GOC:dph, GOC:tb]
is_a: GO:0010969 ! regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion
is_a: GO:0045745 ! positive regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:0060239 ! positive regulation of signal transduction involved in conjugation with cellular fusion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000750 ! pheromone-dependent signal transduction involved in conjugation with cellular fusion
relationship: positively_regulates GO:0000750 ! pheromone-dependent signal transduction involved in conjugation with cellular fusion
created_by: tanyaberardini
creation_date: 2009-08-03T10:25:27Z

[Term]
id: GO:0090029
name: negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of pheromone-dependent signal transduction during conjugation with cellular fusion, a signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion." [GOC:dph, GOC:tb]
is_a: GO:0010969 ! regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion
is_a: GO:0045744 ! negative regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:0060240 ! negative regulation of signal transduction involved in conjugation with cellular fusion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000750 ! pheromone-dependent signal transduction involved in conjugation with cellular fusion
relationship: negatively_regulates GO:0000750 ! pheromone-dependent signal transduction involved in conjugation with cellular fusion
created_by: tanyaberardini
creation_date: 2009-08-03T10:27:04Z

[Term]
id: GO:0090030
name: regulation of steroid hormone biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones." [GOC:dph, GOC:tb]
is_a: GO:0046885 ! regulation of hormone biosynthetic process
is_a: GO:0050810 ! regulation of steroid biosynthetic process
created_by: tanyaberardini
creation_date: 2009-08-03T10:38:27Z

[Term]
id: GO:0090031
name: positive regulation of steroid hormone biosynthetic process
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones." [GOC:dph, GOC:tb]
is_a: GO:0010893 ! positive regulation of steroid biosynthetic process
is_a: GO:0046886 ! positive regulation of hormone biosynthetic process
is_a: GO:0090030 ! regulation of steroid hormone biosynthetic process
created_by: tanyaberardini
creation_date: 2009-08-03T10:40:32Z

[Term]
id: GO:0090032
name: negative regulation of steroid hormone biosynthetic process
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones." [GOC:dph, GOC:tb]
is_a: GO:0010894 ! negative regulation of steroid biosynthetic process
is_a: GO:0032353 ! negative regulation of hormone biosynthetic process
is_a: GO:0090030 ! regulation of steroid hormone biosynthetic process
created_by: tanyaberardini
creation_date: 2009-08-03T10:41:35Z

[Term]
id: GO:0090033
name: positive regulation of filamentous growth
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the process in which a multicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape." [GOC:dph, GOC:tb]
is_a: GO:0010570 ! regulation of filamentous growth
is_a: GO:0045927 ! positive regulation of growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030447 ! filamentous growth
relationship: positively_regulates GO:0030447 ! filamentous growth
created_by: tanyaberardini
creation_date: 2009-08-03T11:04:21Z

[Term]
id: GO:0090034
name: regulation of chaperone-mediated protein complex assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of chaperone-mediated protein complex assembly. Chaperone-mediated protein complex assembly is the aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0043254 ! regulation of protein complex assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051131 ! chaperone-mediated protein complex assembly
relationship: regulates GO:0051131 ! chaperone-mediated protein complex assembly
created_by: tanyaberardini
creation_date: 2009-08-03T11:12:37Z

[Term]
id: GO:0090035
name: positive regulation of chaperone-mediated protein complex assembly
namespace: biological_process
def: "Any process that increases the frequency, rate, or extent of chaperone-mediated protein complex assembly. Chaperone-mediated protein complex assembly is the aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0031334 ! positive regulation of protein complex assembly
is_a: GO:0090034 ! regulation of chaperone-mediated protein complex assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051131 ! chaperone-mediated protein complex assembly
relationship: positively_regulates GO:0051131 ! chaperone-mediated protein complex assembly
created_by: tanyaberardini
creation_date: 2009-08-03T11:15:25Z

[Term]
id: GO:0090036
name: regulation of protein kinase C signaling
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound." [GOC:dph, GOC:tb]
synonym: "regulation of protein kinase C signaling cascade" RELATED [GOC:signaling]
synonym: "regulation of protein kinase C signalling cascade" RELATED [GOC:mah]
is_a: GO:1902531 ! regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070528 ! protein kinase C signaling
relationship: regulates GO:0070528 ! protein kinase C signaling
created_by: tanyaberardini
creation_date: 2009-08-03T11:27:26Z

[Term]
id: GO:0090037
name: positive regulation of protein kinase C signaling
namespace: biological_process
def: "Any process that increases the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound." [GOC:dph, GOC:tb]
synonym: "positive regulation of protein kinase C signaling cascade" RELATED [GOC:signaling]
synonym: "positive regulation of protein kinase C signalling cascade" EXACT [GOC:mah]
is_a: GO:0090036 ! regulation of protein kinase C signaling
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070528 ! protein kinase C signaling
relationship: positively_regulates GO:0070528 ! protein kinase C signaling
created_by: tanyaberardini
creation_date: 2009-08-03T11:28:44Z

[Term]
id: GO:0090038
name: negative regulation of protein kinase C signaling
namespace: biological_process
def: "Any process that decreases the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound." [GOC:dph, GOC:tb]
synonym: "negative regulation of protein kinase C signaling cascade" RELATED [GOC:signaling]
synonym: "negative regulation of protein kinase C signalling cascade" RELATED [GOC:mah]
is_a: GO:0090036 ! regulation of protein kinase C signaling
is_a: GO:1902532 ! negative regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070528 ! protein kinase C signaling
relationship: negatively_regulates GO:0070528 ! protein kinase C signaling
created_by: tanyaberardini
creation_date: 2009-08-03T11:29:33Z

[Term]
id: GO:0090042
name: tubulin deacetylation
namespace: biological_process
def: "The removal of an acetyl group from tubulin. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0006476 ! protein deacetylation
created_by: tanyaberardini
creation_date: 2009-08-03T11:50:47Z

[Term]
id: GO:0090043
name: regulation of tubulin deacetylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tubulin deacetylation. Tubulin deacetylation is the removal of an acetyl group from a protein amino acid." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0090311 ! regulation of protein deacetylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0090042 ! tubulin deacetylation
relationship: regulates GO:0090042 ! tubulin deacetylation
created_by: tanyaberardini
creation_date: 2009-08-03T11:53:07Z

[Term]
id: GO:0090044
name: positive regulation of tubulin deacetylation
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of tubulin deacetylation. Tubulin deacetylation is the removal of an acetyl group from a protein amino acid." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0090043 ! regulation of tubulin deacetylation
is_a: GO:0090312 ! positive regulation of protein deacetylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0090042 ! tubulin deacetylation
relationship: positively_regulates GO:0090042 ! tubulin deacetylation
created_by: tanyaberardini
creation_date: 2009-08-03T11:54:18Z

[Term]
id: GO:0090045
name: positive regulation of deacetylase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of deacetylase activity, the catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0051345 ! positive regulation of hydrolase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0019213 ! deacetylase activity
relationship: positively_regulates GO:0019213 ! deacetylase activity
created_by: tanyaberardini
creation_date: 2009-08-03T12:00:14Z

[Term]
id: GO:0090046
name: obsolete regulation of transcription regulator activity
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription regulator activity, any molecular function that plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor." [GOC:BHF, GOC:rl]
comment: At the time of obsoletion, under "regulation of molecular function", a term exists for "regulation of sequence-specific DNA binding transcription factor activity" and the positive and negative child terms, but no more detailed terms exist. In reannotating, please consider if the paper would support annotation to a regulation term for a specific RNA polymerase. Also consider if what you need would be regulation of protein binding transcription factor activity or any of its child terms instead. If so, please consider making a SF item regarding creation of such a term.
synonym: "regulation of transcription regulator activity" EXACT []
is_obsolete: true
created_by: tanyaberardini
creation_date: 2009-08-07T10:19:57Z

[Term]
id: GO:0090047
name: obsolete positive regulation of transcription regulator activity
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription regulator activity, any molecular function that plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor." [GOC:BHF, GOC:rl]
comment: At the time of obsoletion, under "regulation of molecular function", a term exists for "regulation of sequence-specific DNA binding transcription factor activity" and the positive and negative child terms, but no more detailed terms exist. In reannotating, please consider if the paper would support annotation to a regulation term for a specific RNA polymerase. Also consider if what you need would be regulation of protein binding transcription factor activity or any of its child terms instead. If so, please consider making a SF item regarding creation of such a term.
synonym: "positive regulation of transcription regulator activity" EXACT []
is_obsolete: true
created_by: tanyaberardini
creation_date: 2009-08-07T10:24:24Z

[Term]
id: GO:0090048
name: obsolete negative regulation of transcription regulator activity
namespace: biological_process
def: "OBSOLETE. Any process that decreases the frequency, rate or extent of transcription regulator activity, any molecular function that plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor." [GOC:BHF, GOC:rl]
comment: At the time of obsoletion, under "regulation of molecular function", a term exists for "regulation of sequence-specific DNA binding transcription factor activity" and the positive and negative child terms, but no more detailed terms exist. In reannotating, please consider if the paper would support annotation to a regulation term for a specific RNA polymerase. Also consider if what you need would be regulation of protein binding transcription factor activity or any of its child terms instead. If so, please consider making a SF item regarding creation of such a term.
synonym: "negative regulation of transcription regulator activity" EXACT []
is_obsolete: true
created_by: tanyaberardini
creation_date: 2009-08-07T10:25:04Z

[Term]
id: GO:0090049
name: regulation of cell migration involved in sprouting angiogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]
is_a: GO:0043535 ! regulation of blood vessel endothelial cell migration
is_a: GO:1903670 ! regulation of sprouting angiogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002042 ! cell migration involved in sprouting angiogenesis
relationship: regulates GO:0002042 ! cell migration involved in sprouting angiogenesis
created_by: tanyaberardini
creation_date: 2009-08-07T10:37:16Z

[Term]
id: GO:0090050
name: positive regulation of cell migration involved in sprouting angiogenesis
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]
is_a: GO:0043536 ! positive regulation of blood vessel endothelial cell migration
is_a: GO:0090049 ! regulation of cell migration involved in sprouting angiogenesis
is_a: GO:1903672 ! positive regulation of sprouting angiogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002042 ! cell migration involved in sprouting angiogenesis
relationship: positively_regulates GO:0002042 ! cell migration involved in sprouting angiogenesis
created_by: tanyaberardini
creation_date: 2009-08-07T10:41:09Z

[Term]
id: GO:0090051
name: negative regulation of cell migration involved in sprouting angiogenesis
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]
is_a: GO:0043537 ! negative regulation of blood vessel endothelial cell migration
is_a: GO:0090049 ! regulation of cell migration involved in sprouting angiogenesis
is_a: GO:1903671 ! negative regulation of sprouting angiogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002042 ! cell migration involved in sprouting angiogenesis
relationship: negatively_regulates GO:0002042 ! cell migration involved in sprouting angiogenesis
created_by: tanyaberardini
creation_date: 2009-08-07T10:42:00Z

[Term]
id: GO:0090052
name: regulation of chromatin silencing at centromere
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chromatin silencing at the centromere. Chromatin silencing at the centromere is the repression of transcription of centromeric DNA by altering the structure of chromatin." [GOC:dph, GOC:tb]
is_a: GO:0031935 ! regulation of chromatin silencing
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030702 ! chromatin silencing at centromere
relationship: regulates GO:0030702 ! chromatin silencing at centromere
created_by: tanyaberardini
creation_date: 2009-08-07T10:47:41Z

[Term]
id: GO:0090053
name: positive regulation of chromatin silencing at centromere
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of chromatin silencing at the centromere. Chromatin silencing at the centromere is the repression of transcription of centromeric DNA by altering the structure of chromatin." [GOC:dph, GOC:tb]
is_a: GO:0031937 ! positive regulation of chromatin silencing
is_a: GO:0090052 ! regulation of chromatin silencing at centromere
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030702 ! chromatin silencing at centromere
relationship: positively_regulates GO:0030702 ! chromatin silencing at centromere
created_by: tanyaberardini
creation_date: 2009-08-07T10:49:40Z

[Term]
id: GO:0090054
name: regulation of chromatin silencing at silent mating-type cassette
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of chromatin silencing at silent mating-type cassette. Chromatin silencing at silent mating-type cassette is the repression of transcription at silent mating-type loci by altering the structure of chromatin." [GOC:dph, GOC:tb]
is_a: GO:0031935 ! regulation of chromatin silencing
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030466 ! chromatin silencing at silent mating-type cassette
relationship: regulates GO:0030466 ! chromatin silencing at silent mating-type cassette
created_by: tanyaberardini
creation_date: 2009-08-07T10:52:59Z

[Term]
id: GO:0090055
name: positive regulation of chromatin silencing at silent mating-type cassette
namespace: biological_process
def: "Any process that increases the frequency, rate, or extent of chromatin silencing at silent mating-type cassette. Chromatin silencing at silent mating-type cassette is the repression of transcription at silent mating-type loci by altering the structure of chromatin." [GOC:dph, GOC:tb]
is_a: GO:0031937 ! positive regulation of chromatin silencing
is_a: GO:0090054 ! regulation of chromatin silencing at silent mating-type cassette
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030466 ! chromatin silencing at silent mating-type cassette
relationship: positively_regulates GO:0030466 ! chromatin silencing at silent mating-type cassette
created_by: tanyaberardini
creation_date: 2009-08-07T10:54:36Z

[Term]
id: GO:0090056
name: regulation of chlorophyll metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving chlorophyll." [GOC:dph, GOC:tb]
is_a: GO:0051193 ! regulation of cofactor metabolic process
is_a: GO:1901401 ! regulation of tetrapyrrole metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0015994 ! chlorophyll metabolic process
relationship: regulates GO:0015994 ! chlorophyll metabolic process
created_by: tanyaberardini
creation_date: 2009-08-07T11:47:27Z

[Term]
id: GO:0090057
name: root radial pattern formation
namespace: biological_process
def: "The radial pattern formation process that results in the formation of the different tissues of the root around its radial axis." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0009956 ! radial pattern formation
relationship: part_of GO:0048364 ! root development
created_by: tanyaberardini
creation_date: 2009-08-11T02:58:06Z

[Term]
id: GO:0090058
name: metaxylem development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metaxylem over time, from its formation to the mature structure. The metaxylem is the part of the primary xylem that differentiates after the protoxylem and before the secondary xylem, if any of the latter is formed." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0010089 ! xylem development
is_a: GO:0044767 ! single-organism developmental process
created_by: tanyaberardini
creation_date: 2009-08-11T03:05:15Z

[Term]
id: GO:0090059
name: protoxylem development
namespace: biological_process
def: "The process whose specific outcome is the progression of the protoxylem over time, from its formation to the mature structure. The protoxylem comprises the first formed elements of the primary xylem." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0010089 ! xylem development
created_by: tanyaberardini
creation_date: 2009-08-11T03:08:06Z

[Term]
id: GO:0090060
name: regulation of metaxylem development
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of metaxylem development. Metaxylem development is the process whose specific outcome is the progression of the metaxylem over time, from its formation to the mature structure. The metaxylem is the part of the primary xylem that differentiates after the protoxylem and before the secondary xylem, if any of the latter is formed." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0090058 ! metaxylem development
relationship: regulates GO:0090058 ! metaxylem development
created_by: tanyaberardini
creation_date: 2009-08-11T03:14:54Z

[Term]
id: GO:0090062
name: regulation of trehalose metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of trehalose metabolism, the chemical reactions and pathways involving trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:dph, GOC:tb]
is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0005991 ! trehalose metabolic process
relationship: regulates GO:0005991 ! trehalose metabolic process
created_by: tanyaberardini
creation_date: 2009-08-12T11:24:29Z

[Term]
id: GO:0090063
name: positive regulation of microtubule nucleation
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell." [GOC:dph, GOC:tb]
is_a: GO:0010968 ! regulation of microtubule nucleation
is_a: GO:0031116 ! positive regulation of microtubule polymerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007020 ! microtubule nucleation
relationship: positively_regulates GO:0007020 ! microtubule nucleation
created_by: tanyaberardini
creation_date: 2009-08-12T11:33:09Z

[Term]
id: GO:0090064
name: activation of microtubule nucleation
namespace: biological_process
def: "Any process that starts the inactive process of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell." [GOC:dph, GOC:tb]
is_a: GO:0090063 ! positive regulation of microtubule nucleation
created_by: tanyaberardini
creation_date: 2009-08-12T11:36:15Z

[Term]
id: GO:0090065
name: regulation of production of siRNA involved in RNA interference
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the production of siRNA, the cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of RNA interference." [GOC:dph, GOC:mah, GOC:tb]
synonym: "regulation of RNA interference, production of siRNA" EXACT [GOC:mah]
is_a: GO:0070920 ! regulation of production of small RNA involved in gene silencing by RNA
is_a: GO:1900368 ! regulation of RNA interference
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030422 ! production of siRNA involved in RNA interference
relationship: regulates GO:0030422 ! production of siRNA involved in RNA interference
created_by: tanyaberardini
creation_date: 2009-08-12T11:41:09Z

[Term]
id: GO:0090066
name: regulation of anatomical structure size
namespace: biological_process
def: "Any process that modulates the size of an anatomical structure." [GOC:dph, GOC:tb]
subset: gosubset_prok
is_a: GO:0065008 ! regulation of biological quality
created_by: tanyaberardini
creation_date: 2009-09-02T11:00:08Z

[Term]
id: GO:0090067
name: regulation of thalamus size
namespace: biological_process
def: "Any process that modulates the size of the thalamus. The thalamus is a part of the diencephalon that is composed of the dorsal thalamus and the ventral thalamus." [GOC:dph, GOC:tb]
is_a: GO:0090066 ! regulation of anatomical structure size
created_by: tanyaberardini
creation_date: 2009-09-02T11:03:03Z

[Term]
id: GO:0090068
name: positive regulation of cell cycle process
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb]
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0045787 ! positive regulation of cell cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0022402 ! cell cycle process
relationship: positively_regulates GO:0022402 ! cell cycle process
created_by: tanyaberardini
creation_date: 2009-09-09T11:39:52Z

[Term]
id: GO:0090069
name: regulation of ribosome biogenesis
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits." [GOC:dph, GOC:tb]
is_a: GO:0044087 ! regulation of cellular component biogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042254 ! ribosome biogenesis
relationship: regulates GO:0042254 ! ribosome biogenesis
created_by: tanyaberardini
creation_date: 2009-09-11T10:32:17Z

[Term]
id: GO:0090070
name: positive regulation of ribosome biogenesis
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits." [GOC:dph, GOC:tb]
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:0090069 ! regulation of ribosome biogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042254 ! ribosome biogenesis
relationship: positively_regulates GO:0042254 ! ribosome biogenesis
created_by: tanyaberardini
creation_date: 2009-09-11T10:32:17Z

[Term]
id: GO:0090071
name: negative regulation of ribosome biogenesis
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits." [GOC:dph, GOC:tb]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0090069 ! regulation of ribosome biogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042254 ! ribosome biogenesis
relationship: negatively_regulates GO:0042254 ! ribosome biogenesis
created_by: tanyaberardini
creation_date: 2009-09-11T10:32:17Z

[Term]
id: GO:0090072
name: obsolete positive regulation of sodium ion transport via voltage-gated sodium channel activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the directed movement of sodium ions via the activity of voltage-gated sodium channels." [GOC:dph, GOC:tb]
comment: This term was made obsolete because it is ill-defined: channel activities are part of ion transport processes, and not the other way round.
synonym: "positive regulation of sodium ion transport via voltage-gated sodium channel activity" EXACT []
is_obsolete: true
consider: GO:0005248
created_by: tanyaberardini
creation_date: 2009-09-11T10:46:13Z

[Term]
id: GO:0090073
name: positive regulation of protein homodimerization activity
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer." [GOC:dph, GOC:tb]
is_a: GO:0032092 ! positive regulation of protein binding
is_a: GO:0043496 ! regulation of protein homodimerization activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042803 ! protein homodimerization activity
relationship: positively_regulates GO:0042803 ! protein homodimerization activity
created_by: tanyaberardini
creation_date: 2009-09-11T11:15:40Z

[Term]
id: GO:0090074
name: negative regulation of protein homodimerization activity
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer." [GOC:dph, GOC:tb]
is_a: GO:0032091 ! negative regulation of protein binding
is_a: GO:0043496 ! regulation of protein homodimerization activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042803 ! protein homodimerization activity
relationship: negatively_regulates GO:0042803 ! protein homodimerization activity
created_by: tanyaberardini
creation_date: 2009-09-11T11:15:40Z

[Term]
id: GO:0090075
name: relaxation of muscle
namespace: biological_process
def: "A process in which the extent of muscle contraction is reduced. Muscle relaxation can involve a number of processes including the removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases. In some muscles, calcium-independent pathways also play a role in muscle relaxation by decreasing the phosphorylation state of myosin light chain." [GOC:BHF, GOC:rl, PMID:19996365]
is_a: GO:0003012 ! muscle system process
created_by: tanyaberardini
creation_date: 2009-09-11T11:43:38Z

[Term]
id: GO:0090076
name: relaxation of skeletal muscle
namespace: biological_process
def: "A process in which the extent of skeletal muscle tissue contraction is reduced. Muscle relaxation involves the removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases." [GOC:BHF, GOC:rl]
is_a: GO:0090075 ! relaxation of muscle
created_by: tanyaberardini
creation_date: 2009-09-11T11:44:32Z

[Term]
id: GO:0090077
name: foam cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions." [GOC:add, GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0030154 ! cell differentiation
created_by: tanyaberardini
creation_date: 2009-09-15T03:46:30Z

[Term]
id: GO:0090078
name: smooth muscle derived foam cell differentiation
namespace: biological_process
def: "The process in which a smooth muscle cell acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions." [GOC:add, GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0090077 ! foam cell differentiation
created_by: tanyaberardini
creation_date: 2009-09-15T03:48:10Z

[Term]
id: GO:0090079
name: translation regulator activity, nucleic acid binding
namespace: molecular_function
def: "Any selective and non-covalent interaction with a nucleic acid involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome." [GOC:dph, GOC:tb, GOC:vw]
is_a: GO:0003676 ! nucleic acid binding
is_a: GO:0045182 ! translation regulator activity
created_by: tanyaberardini
creation_date: 2009-10-19T10:19:05Z

[Term]
id: GO:0090080
name: positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands resulting in an increase in the rate or frequency of a MAPKKK cascade." [GOC:dph, GOC:tb]
synonym: "positive regulation of MAPKKK cascade by fibroblast growth factor receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway
is_a: GO:0043410 ! positive regulation of MAPK cascade
intersection_of: GO:0008543 ! fibroblast growth factor receptor signaling pathway
intersection_of: positively_regulates GO:0000165 ! MAPK cascade
relationship: positively_regulates GO:0000165 ! MAPK cascade
created_by: tanyaberardini
creation_date: 2009-10-19T11:30:22Z

[Term]
id: GO:0090081
name: regulation of heart induction by regulation of canonical Wnt signaling pathway
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of canonical Wnt signaling pathway that regulates heart induction. Canonical Wnt signaling pathway involved in heart induction is the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, followed by relaying of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:mtg_heart]
synonym: "regulation of heart induction by regulation of canonical Wnt receptor signaling pathway" EXACT []
synonym: "regulation of heart induction by regulation of canonical Wnt receptor signalling pathway" EXACT [GOC:mah]
synonym: "regulation of heart induction by regulation of canonical Wnt-activated signaling pathway" EXACT [GOC:signaling]
is_a: GO:0003307 ! regulation of Wnt signaling pathway involved in heart development
is_a: GO:0042659 ! regulation of cell fate specification
is_a: GO:0060828 ! regulation of canonical Wnt signaling pathway
is_a: GO:0090381 ! regulation of heart induction
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: regulates GO:0100012 ! regulation of heart induction by canonical Wnt signaling pathway
relationship: regulates GO:0100012 ! regulation of heart induction by canonical Wnt signaling pathway
created_by: tanyaberardini
creation_date: 2009-10-23T10:55:18Z

[Term]
id: GO:0090082
name: positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of canonical Wnt signaling pathway that positively regulates heart induction. Canonical Wnt signaling pathway involved in heart induction is the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:mtg_heart, PMID:16860783]
synonym: "positive regulation of heart induction by negative regulation of canonical Wnt receptor signaling pathway" EXACT []
synonym: "positive regulation of heart induction by negative regulation of canonical Wnt receptor signalling pathway" EXACT [GOC:mah]
synonym: "positive regulation of heart induction by negative regulation of canonical Wnt-activated signaling pathway" EXACT [GOC:signaling]
is_a: GO:0003308 ! negative regulation of Wnt signaling pathway involved in heart development
is_a: GO:0090081 ! regulation of heart induction by regulation of canonical Wnt signaling pathway
is_a: GO:0090090 ! negative regulation of canonical Wnt signaling pathway
is_a: GO:1901321 ! positive regulation of heart induction
relationship: positively_regulates GO:0003129 ! heart induction
created_by: tanyaberardini
creation_date: 2009-10-23T10:58:03Z

[Term]
id: GO:0090083
name: regulation of inclusion body assembly
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of inclusion body assembly. Inclusion body assembly is the aggregation, arrangement and bonding together of a set of components to form an inclusion body." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070841 ! inclusion body assembly
relationship: regulates GO:0070841 ! inclusion body assembly
created_by: tanyaberardini
creation_date: 2009-10-23T11:07:22Z

[Term]
id: GO:0090084
name: negative regulation of inclusion body assembly
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of inclusion body assembly. Inclusion body assembly is the aggregation, arrangement and bonding together of a set of components to form an inclusion body." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:0090083 ! regulation of inclusion body assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070841 ! inclusion body assembly
relationship: negatively_regulates GO:0070841 ! inclusion body assembly
created_by: tanyaberardini
creation_date: 2009-10-23T11:08:56Z

[Term]
id: GO:0090085
name: regulation of protein deubiquitination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein deubiquitination. Protein deubiquitination is the removal of one or more ubiquitin groups from a protein." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0030162 ! regulation of proteolysis
is_a: GO:1903320 ! regulation of protein modification by small protein conjugation or removal
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016579 ! protein deubiquitination
relationship: regulates GO:0016579 ! protein deubiquitination
created_by: tanyaberardini
creation_date: 2009-10-23T11:16:32Z

[Term]
id: GO:0090086
name: negative regulation of protein deubiquitination
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of protein deubiquitination. Protein deubiquitination is the removal of one or more ubiquitin groups from a protein." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0045861 ! negative regulation of proteolysis
is_a: GO:0090085 ! regulation of protein deubiquitination
is_a: GO:1903321 ! negative regulation of protein modification by small protein conjugation or removal
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016579 ! protein deubiquitination
relationship: negatively_regulates GO:0016579 ! protein deubiquitination
created_by: tanyaberardini
creation_date: 2009-10-23T11:18:06Z

[Term]
id: GO:0090087
name: regulation of peptide transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb]
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0015833 ! peptide transport
relationship: regulates GO:0015833 ! peptide transport
created_by: tanyaberardini
creation_date: 2009-10-23T11:21:38Z

[Term]
id: GO:0090088
name: regulation of oligopeptide transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of oligopeptides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [GOC:dph, GOC:tb]
is_a: GO:0090087 ! regulation of peptide transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006857 ! oligopeptide transport
relationship: regulates GO:0006857 ! oligopeptide transport
created_by: tanyaberardini
creation_date: 2009-10-23T11:23:18Z

[Term]
id: GO:0090089
name: regulation of dipeptide transport
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of dipeptide transport. Dipeptide transport is the directed movement of a dipeptide, a combination of two amino acids by means of a peptide (-CO-NH-) link, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb]
is_a: GO:0090088 ! regulation of oligopeptide transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042938 ! dipeptide transport
relationship: regulates GO:0042938 ! dipeptide transport
created_by: tanyaberardini
creation_date: 2009-10-23T11:24:36Z

[Term]
id: GO:0090090
name: negative regulation of canonical Wnt signaling pathway
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb]
synonym: "negative regulation of canonical Wnt receptor signaling pathway" EXACT []
synonym: "negative regulation of canonical Wnt receptor signalling pathway" EXACT [GOC:mah]
synonym: "negative regulation of canonical Wnt-activated signaling pathway" EXACT [GOC:signaling]
synonym: "negative regulation of Wnt receptor signaling pathway through beta-catenin" EXACT [GOC:mtg_signal]
is_a: GO:0030178 ! negative regulation of Wnt signaling pathway
is_a: GO:0060828 ! regulation of canonical Wnt signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060070 ! canonical Wnt signaling pathway
relationship: negatively_regulates GO:0060070 ! canonical Wnt signaling pathway
created_by: tanyaberardini
creation_date: 2009-10-30T11:27:17Z

[Term]
id: GO:0090091
name: positive regulation of extracellular matrix disassembly
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix." [GOC:dph, GOC:tb]
is_a: GO:0010715 ! regulation of extracellular matrix disassembly
is_a: GO:1903055 ! positive regulation of extracellular matrix organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0022617 ! extracellular matrix disassembly
relationship: positively_regulates GO:0022617 ! extracellular matrix disassembly
created_by: tanyaberardini
creation_date: 2009-11-04T10:03:25Z

[Term]
id: GO:0090092
name: regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand." [GOC:dph, GOC:tb]
synonym: "regulation of transmembrane receptor protein serine/threonine kinase signalling pathway" EXACT [GOC:mah]
is_a: GO:0009966 ! regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway
relationship: regulates GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway
created_by: tanyaberardini
creation_date: 2009-11-04T11:46:40Z

[Term]
id: GO:0090093
name: regulation of fungal-type cell wall beta-glucan biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fungal-type cell wall beta-glucan biosynthesis, the chemical reactions and pathways resulting in the formation of beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of fungal cells." [GOC:dph, GOC:tb]
is_a: GO:0010981 ! regulation of cell wall macromolecule metabolic process
is_a: GO:0032951 ! regulation of beta-glucan biosynthetic process
is_a: GO:0032995 ! regulation of fungal-type cell wall biogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070880 ! fungal-type cell wall beta-glucan biosynthetic process
relationship: regulates GO:0070880 ! fungal-type cell wall beta-glucan biosynthetic process
created_by: tanyaberardini
creation_date: 2009-11-13T10:10:38Z

[Term]
id: GO:0090094
name: metanephric cap mesenchymal cell proliferation involved in metanephros development
namespace: biological_process
def: "The multiplication or reproduction of metanephric cap mesenchymal cells, resulting in the expansion of the cell population. A metanephric cap mesenchymal cell is a mesenchymal cell that has condensed with other mesenchymal cells surrounding the ureteric bud tip." [GOC:dph, GOC:tb, GOC:yaf, PMID:19161241]
is_a: GO:0010463 ! mesenchymal cell proliferation
is_a: GO:0072203 ! cell proliferation involved in metanephros development
relationship: part_of GO:0072186 ! metanephric cap morphogenesis
created_by: tanyaberardini
creation_date: 2009-11-13T10:34:10Z

[Term]
id: GO:0090095
name: regulation of metanephric cap mesenchymal cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of metanephric cap mesenchymal cell proliferation. Metanephric cap mesenchymal cell proliferation is the multiplication or reproduction of metanephric cap mesenchymal cells, resulting in the expansion of the cell population. A metanephric cap mesenchymal cell is a mesenchymal cell that has condensed with other mesenchymal cells surrounding the ureteric bud tip." [GOC:dph, GOC:tb, GOC:yaf]
is_a: GO:0010464 ! regulation of mesenchymal cell proliferation
is_a: GO:0072215 ! regulation of metanephros development
is_a: GO:1901722 ! regulation of cell proliferation involved in kidney development
is_a: GO:2000027 ! regulation of organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0090094 ! metanephric cap mesenchymal cell proliferation involved in metanephros development
relationship: regulates GO:0090094 ! metanephric cap mesenchymal cell proliferation involved in metanephros development
created_by: tanyaberardini
creation_date: 2009-11-13T10:40:32Z

[Term]
id: GO:0090096
name: positive regulation of metanephric cap mesenchymal cell proliferation
namespace: biological_process
def: "Any process that increases the frequency, rate, or extent of metanephric cap mesenchymal cell proliferation. Metanephric cap mesenchymal cell proliferation is the multiplication or reproduction of metanephric cap mesenchymal cells, resulting in the expansion of the cell population. A metanephric cap mesenchymal cell is a mesenchymal cell that has condensed with other mesenchymal cells surrounding the ureteric bud tip." [GOC:dph, GOC:tb, GOC:yaf]
is_a: GO:0002053 ! positive regulation of mesenchymal cell proliferation
is_a: GO:0072216 ! positive regulation of metanephros development
is_a: GO:0090095 ! regulation of metanephric cap mesenchymal cell proliferation
is_a: GO:1901724 ! positive regulation of cell proliferation involved in kidney development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0090094 ! metanephric cap mesenchymal cell proliferation involved in metanephros development
relationship: positively_regulates GO:0090094 ! metanephric cap mesenchymal cell proliferation involved in metanephros development
created_by: tanyaberardini
creation_date: 2009-11-13T10:40:32Z

[Term]
id: GO:0090097
name: regulation of decapentaplegic signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the decapentaplegic signaling pathway. The decapentaplegic signaling pathway is the series of molecular signals generated as a consequence of the signal decapentaplegic binding to one of its physiological receptors." [GOC:dph, GOC:tb]
synonym: "regulation of decapentaplegic receptor signaling pathway" EXACT [GOC:bf]
synonym: "regulation of decapentaplegic receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008101 ! decapentaplegic signaling pathway
relationship: regulates GO:0008101 ! decapentaplegic signaling pathway
created_by: tanyaberardini
creation_date: 2009-11-13T10:49:14Z

[Term]
id: GO:0090098
name: positive regulation of decapentaplegic signaling pathway
namespace: biological_process
def: "Any process that increases the frequency, rate, or extent of the decapentaplegic signaling pathway. The decapentaplegic signaling pathway is the series of molecular signals generated as a consequence of the signal decapentaplegic binding to one of its physiological receptors." [GOC:dph, GOC:tb]
synonym: "positive regulation of decapentaplegic receptor signaling pathway" EXACT [GOC:bf]
synonym: "positive regulation of decapentaplegic receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0090097 ! regulation of decapentaplegic signaling pathway
is_a: GO:0090100 ! positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008101 ! decapentaplegic signaling pathway
relationship: positively_regulates GO:0008101 ! decapentaplegic signaling pathway
created_by: tanyaberardini
creation_date: 2009-11-13T10:50:41Z

[Term]
id: GO:0090099
name: negative regulation of decapentaplegic signaling pathway
namespace: biological_process
def: "Any process that decreases the frequency, rate, or extent of the decapentaplegic signaling pathway. The decapentaplegic signaling pathway is the series of molecular signals generated as a consequence of the signal decapentaplegic binding to one of its physiological receptors." [GOC:dph, GOC:tb]
synonym: "negative regulation of decapentaplegic receptor signaling pathway" EXACT [GOC:bf]
synonym: "negative regulation of decapentaplegic receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0090097 ! regulation of decapentaplegic signaling pathway
is_a: GO:0090101 ! negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008101 ! decapentaplegic signaling pathway
relationship: negatively_regulates GO:0008101 ! decapentaplegic signaling pathway
created_by: tanyaberardini
creation_date: 2009-11-13T10:51:30Z

[Term]
id: GO:0090100
name: positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand." [GOC:dph, GOC:tb]
synonym: "positive regulation of transmembrane receptor protein serine/threonine kinase signalling pathway" EXACT [GOC:mah]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway
relationship: positively_regulates GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway
created_by: tanyaberardini
creation_date: 2009-11-13T10:55:53Z

[Term]
id: GO:0090101
name: negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand." [GOC:dph, GOC:tb]
synonym: "negative regulation of transmembrane receptor protein serine/threonine kinase signalling pathway" EXACT [GOC:mah]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway
relationship: negatively_regulates GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway
created_by: tanyaberardini
creation_date: 2009-11-13T10:56:52Z

[Term]
id: GO:0090102
name: cochlea development
namespace: biological_process
def: "The progression of the cochlea over time from its formation to the mature structure. The cochlea is the snail-shaped portion of the inner ear that is responsible for the detection of sound." [GOC:dph, GOC:tb]
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048839 ! inner ear development
created_by: tanyaberardini
creation_date: 2009-11-18T11:42:15Z

[Term]
id: GO:0090103
name: cochlea morphogenesis
namespace: biological_process
def: "The process in which the cochlea is generated and organized." [GOC:dph, GOC:tb]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0042472 ! inner ear morphogenesis
relationship: part_of GO:0090102 ! cochlea development
created_by: tanyaberardini
creation_date: 2009-11-18T11:45:11Z

[Term]
id: GO:0090104
name: pancreatic epsilon cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic epsilon cell. A pancreatic epsilon cell is a cell in the pancreas that secretes ghrelin." [GOC:dph, GOC:tb]
synonym: "pancreatic E cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0031018 ! endocrine pancreas development
created_by: tanyaberardini
creation_date: 2009-11-18T11:48:52Z

[Term]
id: GO:0090105
name: pancreatic E cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a pancreatic E cell over time, from its formation to the mature structure." [GOC:dph, GOC:tb]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0090104 ! pancreatic epsilon cell differentiation
created_by: tanyaberardini
creation_date: 2009-11-18T11:51:00Z

[Term]
id: GO:0090106
name: pancreatic E cell fate commitment
namespace: biological_process
def: "The commitment of a cell to a pancreatic E cell fate and its capacity to differentiate into a pancreatic E cell." [GOC:dph, GOC:tb]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0090104 ! pancreatic epsilon cell differentiation
created_by: tanyaberardini
creation_date: 2009-11-18T11:51:41Z

[Term]
id: GO:0090107
name: regulation of high-density lipoprotein particle assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of high-density lipoprotein particle assembly. High-density lipoprotein particle assembly is the aggregation and arrangement of proteins and lipids to form a high-density lipoprotein particle." [GOC:dph, GOC:tb]
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0051128 ! regulation of cellular component organization
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034380 ! high-density lipoprotein particle assembly
relationship: regulates GO:0034380 ! high-density lipoprotein particle assembly
created_by: tanyaberardini
creation_date: 2009-11-25T10:50:18Z

[Term]
id: GO:0090108
name: positive regulation of high-density lipoprotein particle assembly
namespace: biological_process
def: "Any process that increases the frequency, rate, or extent of high-density lipoprotein particle assembly. High-density lipoprotein particle assembly is the aggregation and arrangement of proteins and lipids to form a high-density lipoprotein particle." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0090107 ! regulation of high-density lipoprotein particle assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034380 ! high-density lipoprotein particle assembly
relationship: positively_regulates GO:0034380 ! high-density lipoprotein particle assembly
created_by: tanyaberardini
creation_date: 2009-11-25T10:50:18Z

[Term]
id: GO:0090109
name: regulation of cell-substrate junction assembly
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of cell-substrate junction assembly. Cell-substrate junction assembly is the aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate." [GOC:dph, GOC:tb]
is_a: GO:1901888 ! regulation of cell junction assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007044 ! cell-substrate junction assembly
relationship: regulates GO:0007044 ! cell-substrate junction assembly
created_by: tanyaberardini
creation_date: 2009-11-25T11:00:58Z

[Term]
id: GO:0090110
name: cargo loading into COPII-coated vesicle
namespace: biological_process
def: "The formation of a protein complex between the COPII coat proteins and proteins that are going to be transported by the COPII vesicle to the Golgi." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "cargo loading into COPII vesicle" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "cargo selection into COPII-coated vesicle" EXACT [GOC:vw]
synonym: "COPII coat-cargo complex assembly" RELATED [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb]
is_a: GO:0035459 ! cargo loading into vesicle
is_a: GO:0051668 ! localization within membrane
is_a: GO:1902580 ! single-organism cellular localization
is_a: GO:1902582 ! single-organism intracellular transport
relationship: part_of GO:0090114 ! COPII-coated vesicle budding
created_by: tanyaberardini
creation_date: 2009-12-06T08:28:34Z

[Term]
id: GO:0090111
name: regulation of COPII vesicle uncoating
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of COPII vesicle uncoating, the process in which COPII vesicle coat proteins are disassembled, and released." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0060628 ! regulation of ER to Golgi vesicle-mediated transport
is_a: GO:1901879 ! regulation of protein depolymerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0090112 ! COPII vesicle uncoating
relationship: regulates GO:0090112 ! COPII vesicle uncoating
created_by: tanyaberardini
creation_date: 2009-12-06T08:34:01Z

[Term]
id: GO:0090112
name: COPII vesicle uncoating
namespace: biological_process
def: "The process in which COPII vesicle coat proteins are disassembled, and released." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0072319 ! vesicle uncoating
relationship: part_of GO:0006888 ! ER to Golgi vesicle-mediated transport
created_by: tanyaberardini
creation_date: 2009-12-06T08:56:50Z

[Term]
id: GO:0090113
name: regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis
namespace: biological_process
def: "The GTP hydrolysis process that modulates the rate, frequency, or extent of ER to Golgi vesicle-mediated transport, the directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0060628 ! regulation of ER to Golgi vesicle-mediated transport
created_by: tanyaberardini
creation_date: 2009-12-06T09:16:14Z

[Term]
id: GO:0090114
name: COPII-coated vesicle budding
namespace: biological_process
def: "The evagination of an endoplasmic reticulum membrane, resulting in formation of a COPII-coated vesicle." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "COPII vesicle budding" RELATED [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb]
synonym: "ER exit" NARROW [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb]
synonym: "ER vesicle budding" BROAD [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb]
is_a: GO:0051668 ! localization within membrane
is_a: GO:1902580 ! single-organism cellular localization
is_a: GO:1902582 ! single-organism intracellular transport
is_a: GO:1902591 ! single-organism membrane budding
relationship: occurs_in GO:0000139 ! Golgi membrane
relationship: part_of GO:0006888 ! ER to Golgi vesicle-mediated transport
created_by: tanyaberardini
creation_date: 2009-12-06T09:21:16Z

[Term]
id: GO:0090115
name: C-5 methylation on cytosine involved in chromatin silencing
namespace: biological_process
def: "The covalent transfer of a methyl group to C-5 of cytosine in a DNA molecule that contributes to chromatin silencing." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0090116 ! C-5 methylation of cytosine
relationship: part_of GO:0006346 ! methylation-dependent chromatin silencing
created_by: tanyaberardini
creation_date: 2009-12-07T11:55:16Z

[Term]
id: GO:0090116
name: C-5 methylation of cytosine
namespace: biological_process
def: "The covalent transfer of a methyl group to C-5 of cytosine in a DNA molecule." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0032776 ! DNA methylation on cytosine
created_by: tanyaberardini
creation_date: 2009-12-07T11:58:47Z

[Term]
id: GO:0090117
name: endosome to lysosome transport of low-density lipoprotein particle
namespace: biological_process
def: "The directed movement of low-density lipoprotein particle from endosomes to lysosomes." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "endosome to lysosome transport of LDL" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0008333 ! endosome to lysosome transport
is_a: GO:0090119 ! vesicle-mediated cholesterol transport
created_by: tanyaberardini
creation_date: 2009-12-07T12:04:34Z

[Term]
id: GO:0090118
name: receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport
namespace: biological_process
def: "A receptor-mediated endocytosis process that results in the uptake of low-density lipoprotein by cells." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "receptor-mediated endocytosis of LDL" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:dph]
is_a: GO:0006898 ! receptor-mediated endocytosis
is_a: GO:1902582 ! single-organism intracellular transport
relationship: part_of GO:0032367 ! intracellular cholesterol transport
relationship: part_of GO:0034383 ! low-density lipoprotein particle clearance
created_by: tanyaberardini
creation_date: 2009-12-07T12:06:05Z

[Term]
id: GO:0090119
name: vesicle-mediated cholesterol transport
namespace: biological_process
def: "The directed movement of cholesterol, cholest-5-en-3-beta-ol, or cholesterol-containing compounds, by membrane-bounded vesicles." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0016192 ! vesicle-mediated transport
is_a: GO:0016482 ! cytosolic transport
is_a: GO:0032367 ! intracellular cholesterol transport
relationship: occurs_in GO:0005829 ! cytosol
created_by: tanyaberardini
creation_date: 2009-12-07T12:14:37Z

[Term]
id: GO:0090120
name: lysosome to ER cholesterol transport
namespace: biological_process
def: "The directed movement of cholesterol, cholest-5-en-3-beta-ol, or cholesterol-containing compounds, from the lysosome to the endoplasmic reticulum." [GOC:mah]
synonym: "lysosome to endoplasmic reticulum cholesterol transport" EXACT [GOC:mah]
is_a: GO:0007041 ! lysosomal transport
is_a: GO:0090119 ! vesicle-mediated cholesterol transport
relationship: occurs_in GO:0005737 ! cytoplasm
created_by: tanyaberardini
creation_date: 2009-12-07T12:22:12Z

[Term]
id: GO:0090121
name: low-density lipoprotein particle disassembly involved in cholesterol transport
namespace: biological_process
def: "The disassembly into constituent parts of the low-density lipoprotein particle in the lysosome that contributes to cholesterol transport." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0090495 ! low-density lipoprotein particle disassembly
intersection_of: GO:0090495 ! low-density lipoprotein particle disassembly
intersection_of: part_of GO:0030301 ! cholesterol transport
relationship: part_of GO:0030301 ! cholesterol transport
created_by: tanyaberardini
creation_date: 2009-12-07T12:59:14Z

[Term]
id: GO:0090122
name: cholesterol ester hydrolysis involved in cholesterol transport
namespace: biological_process
def: "The cholesterol metabolic process in which cholesterol esters are hydrolyzed into free fatty acids and cholesterol in the lysosome that contributes to intracellular cholesterol transport." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0008203 ! cholesterol metabolic process
relationship: part_of GO:0090119 ! vesicle-mediated cholesterol transport
created_by: tanyaberardini
creation_date: 2009-12-07T01:06:54Z

[Term]
id: GO:0090123
name: lysosomal glycocalyx
namespace: cellular_component
def: "The polysaccharide-based coating on the inner side of a lysosomal membrane that protects it from digestion by lysosomal enzymes." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0044437 ! vacuolar part
relationship: part_of GO:0005764 ! lysosome
created_by: tanyaberardini
creation_date: 2009-12-07T01:16:20Z

[Term]
id: GO:0090124
name: N-4 methylation of cytosine
namespace: biological_process
def: "The covalent transfer of a methyl group to N-4 of cytosine in a DNA molecule." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0032776 ! DNA methylation on cytosine
created_by: tanyaberardini
creation_date: 2009-12-07T02:40:38Z

[Term]
id: GO:0090125
name: cell-cell adhesion involved in synapse maturation
namespace: biological_process
def: "The attachment of the pre-synaptic cell to the post-synaptic cell via adhesion molecules that contributes to synapse maturation." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "trans-synaptic adhesion" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0016337 ! single organismal cell-cell adhesion
intersection_of: GO:0016337 ! single organismal cell-cell adhesion
intersection_of: part_of GO:0060074 ! synapse maturation
relationship: part_of GO:0060074 ! synapse maturation
created_by: tanyaberardini
creation_date: 2009-12-07T02:43:24Z

[Term]
id: GO:0090126
name: protein complex assembly involved in synapse maturation
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a protein complex that contributes to synapse maturation." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0006461 ! protein complex assembly
intersection_of: GO:0006461 ! protein complex assembly
intersection_of: part_of GO:0060074 ! synapse maturation
relationship: part_of GO:0060074 ! synapse maturation
created_by: tanyaberardini
creation_date: 2009-12-07T02:49:28Z

[Term]
id: GO:0090127
name: positive regulation of synapse maturation by synaptic transmission
namespace: biological_process
def: "Any process that increases the extent of synaptic maturation as a result of the communication from a pre-synaptic cell to a post-synaptic cell across a synapse." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0007268 ! synaptic transmission
is_a: GO:0090129 ! positive regulation of synapse maturation
intersection_of: GO:0007268 ! synaptic transmission
intersection_of: positively_regulates GO:0060074 ! synapse maturation
relationship: positively_regulates GO:0060074 ! synapse maturation
created_by: tanyaberardini
creation_date: 2009-12-07T02:57:21Z

[Term]
id: GO:0090128
name: regulation of synapse maturation
namespace: biological_process
def: "Any process that modulates the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0050807 ! regulation of synapse organization
is_a: GO:0051960 ! regulation of nervous system development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060074 ! synapse maturation
relationship: regulates GO:0060074 ! synapse maturation
created_by: tanyaberardini
creation_date: 2009-12-07T03:00:58Z

[Term]
id: GO:0090129
name: positive regulation of synapse maturation
namespace: biological_process
def: "Any process that increases the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:0051962 ! positive regulation of nervous system development
is_a: GO:0090128 ! regulation of synapse maturation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060074 ! synapse maturation
relationship: positively_regulates GO:0060074 ! synapse maturation
created_by: tanyaberardini
creation_date: 2009-12-07T03:00:58Z

[Term]
id: GO:0090130
name: tissue migration
namespace: biological_process
def: "The process in which the population of cells that make up a tissue undergo directed movement." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0044707 ! single-multicellular organism process
created_by: tanyaberardini
creation_date: 2009-12-07T03:13:55Z

[Term]
id: GO:0090131
name: mesenchyme migration
namespace: biological_process
def: "The process in which the population of cells that make up a mesenchyme undergo directed movement." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0090130 ! tissue migration
relationship: part_of GO:0072132 ! mesenchyme morphogenesis
created_by: tanyaberardini
creation_date: 2009-12-07T03:15:17Z

[Term]
id: GO:0090132
name: epithelium migration
namespace: biological_process
def: "The process in which the population of cells that make up an epithelium undergo directed movement." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0090130 ! tissue migration
created_by: tanyaberardini
creation_date: 2009-12-07T03:19:34Z

[Term]
id: GO:0090133
name: mesendoderm migration
namespace: biological_process
def: "The process in which the population of cells that make up a mesendoderm undergo directed movement. The mesendoderm is the epithelial tissue that gives rise to both mesoderm and endoderm." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0090132 ! epithelium migration
relationship: part_of GO:0007369 ! gastrulation
relationship: part_of GO:0048382 ! mesendoderm development
created_by: tanyaberardini
creation_date: 2009-12-07T03:22:08Z

[Term]
id: GO:0090134
name: cell migration involved in mesendoderm migration
namespace: biological_process
def: "The orderly movement of epithelial cells from one site to another that contributes to the migration of mesendodermal tissue." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0042074 ! cell migration involved in gastrulation
intersection_of: GO:0016477 ! cell migration
intersection_of: part_of GO:0090133 ! mesendoderm migration
relationship: part_of GO:0090133 ! mesendoderm migration
created_by: tanyaberardini
creation_date: 2009-12-07T03:28:11Z

[Term]
id: GO:0090135
name: actin filament branching
namespace: biological_process
def: "The formation of daughter actin filament branches at an angle on the sides of preexisting mother filaments." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0007015 ! actin filament organization
created_by: tanyaberardini
creation_date: 2009-12-08T01:53:14Z

[Term]
id: GO:0090136
name: epithelial cell-cell adhesion
namespace: biological_process
def: "The attachment of an epithelial cell to another epithelial cell via adhesion molecules." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0016337 ! single organismal cell-cell adhesion
created_by: tanyaberardini
creation_date: 2009-12-08T01:56:53Z

[Term]
id: GO:0090137
name: epithelial cell-cell adhesion involved in epithelium migration
namespace: biological_process
def: "The attachment of an epithelial cell to another epithelial cell via adhesion molecules that contributes to epithelium migration." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0090136 ! epithelial cell-cell adhesion
intersection_of: GO:0090136 ! epithelial cell-cell adhesion
intersection_of: part_of GO:0090132 ! epithelium migration
relationship: part_of GO:0090132 ! epithelium migration
created_by: tanyaberardini
creation_date: 2009-12-08T01:58:19Z

[Term]
id: GO:0090138
name: regulation of actin cytoskeleton organization by cell-cell adhesion
namespace: biological_process
def: "Any cell-cell adhesion process that modulates the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "regulation of actin cytoskeleton organisation by cell-cell adhesion" EXACT [GOC:mah]
is_a: GO:0016337 ! single organismal cell-cell adhesion
is_a: GO:0032956 ! regulation of actin cytoskeleton organization
intersection_of: GO:0016337 ! single organismal cell-cell adhesion
intersection_of: regulates GO:0030036 ! actin cytoskeleton organization
relationship: regulates GO:0030036 ! actin cytoskeleton organization
created_by: tanyaberardini
creation_date: 2009-12-08T02:05:00Z

[Term]
id: GO:0090139
name: mitochondrial DNA packaging
namespace: biological_process
def: "Any process in which mitochondrial DNA and associated proteins are formed into a compact, orderly structure." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0032042 ! mitochondrial DNA metabolic process
is_a: GO:0036385 ! nucleoid DNA packaging
intersection_of: GO:0006323 ! DNA packaging
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion
created_by: tanyaberardini
creation_date: 2009-12-08T02:12:19Z

[Term]
id: GO:0090140
name: regulation of mitochondrial fission
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "regulation of mitochondrial division" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0010821 ! regulation of mitochondrion organization
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000266 ! mitochondrial fission
relationship: regulates GO:0000266 ! mitochondrial fission
created_by: tanyaberardini
creation_date: 2009-12-08T02:20:48Z

[Term]
id: GO:0090141
name: positive regulation of mitochondrial fission
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "positive regulation of mitochondrial division" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0010822 ! positive regulation of mitochondrion organization
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0090140 ! regulation of mitochondrial fission
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000266 ! mitochondrial fission
relationship: positively_regulates GO:0000266 ! mitochondrial fission
created_by: tanyaberardini
creation_date: 2009-12-08T02:20:48Z

[Term]
id: GO:0090143
name: nucleoid organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleoid. The nucleoid is the region of a bacterial cell, virion, mitochondrion or chloroplast to which the DNA is confined." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "nucleoid organisation" EXACT [GOC:mah]
is_a: GO:0016043 ! cellular component organization
is_a: GO:0044763 ! single-organism cellular process
created_by: tanyaberardini
creation_date: 2009-12-08T02:35:48Z

[Term]
id: GO:0090144
name: mitochondrial nucleoid organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial nucleoid. The mitochondrial nucleoid is the region of a mitochondrion to which the DNA is confined." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "mitochondrial nucleoid organisation" EXACT [GOC:mah]
is_a: GO:0090143 ! nucleoid organization
is_a: GO:1902589 ! single-organism organelle organization
intersection_of: GO:0090143 ! nucleoid organization
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion
created_by: tanyaberardini
creation_date: 2009-12-08T02:38:26Z

[Term]
id: GO:0090145
name: mitochondrial nucleoid organization involved in mitochondrial fission
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial nucleoid that contributes to mitochondrial division." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "mitochondrial nucleoid organisation involved in mitochondrial fission" EXACT [GOC:ascb_2009, GOC:bf, GOC:dph, GOC:tb]
is_a: GO:0090144 ! mitochondrial nucleoid organization
intersection_of: GO:0090144 ! mitochondrial nucleoid organization
intersection_of: part_of GO:0000266 ! mitochondrial fission
relationship: part_of GO:0000266 ! mitochondrial fission
created_by: tanyaberardini
creation_date: 2009-12-08T02:39:34Z

[Term]
id: GO:0090146
name: establishment of mitochondrion localization involved in mitochondrial fission
namespace: biological_process
def: "The directed movement of mitochondria to the correct region of the cell that contributes to the process of mitochondrial fission." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "establishment of mitochondrion localisation involved in mitochondrial fission" EXACT [GOC:mah]
synonym: "mitochondrial localization involved in mitochondrial fission" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051654 ! establishment of mitochondrion localization
intersection_of: GO:0051654 ! establishment of mitochondrion localization
intersection_of: part_of GO:0000266 ! mitochondrial fission
relationship: part_of GO:0000266 ! mitochondrial fission
created_by: tanyaberardini
creation_date: 2009-12-08T02:53:15Z

[Term]
id: GO:0090147
name: regulation of establishment of mitochondrion localization involved in mitochondrial fission
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of mitochondria to the correct region of the cell that contributes to the process of mitochondrial fission." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "regulation of establishment of mitochondrion localisation involved in mitochondrial fission" EXACT [GOC:mah]
synonym: "regulation of mitochondrial localization involved in mitochondrial fission" RELATED [GOC:dph, GOC:tb]
is_a: GO:0060341 ! regulation of cellular localization
is_a: GO:0090140 ! regulation of mitochondrial fission
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0090146 ! establishment of mitochondrion localization involved in mitochondrial fission
relationship: regulates GO:0090146 ! establishment of mitochondrion localization involved in mitochondrial fission
created_by: tanyaberardini
creation_date: 2009-12-08T03:01:01Z

[Term]
id: GO:0090148
name: membrane fission
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the separation of a single continuous membrane into two membranes." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0044802 ! single-organism membrane organization
created_by: tanyaberardini
creation_date: 2009-12-08T03:06:36Z

[Term]
id: GO:0090149
name: mitochondrial membrane fission
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the separation of a single continuous mitochondrial membrane into two membranes and contributes to mitochondrial fission." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "membrane fission involved in mitochondrial fission" EXACT []
is_a: GO:0090148 ! membrane fission
intersection_of: GO:0090148 ! membrane fission
intersection_of: part_of GO:0000266 ! mitochondrial fission
relationship: part_of GO:0000266 ! mitochondrial fission
created_by: tanyaberardini
creation_date: 2009-12-08T03:08:57Z

[Term]
id: GO:0090150
name: establishment of protein localization to membrane
namespace: biological_process
def: "The directed movement of a protein to a specific location in a membrane." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "establishment of protein localisation in membrane" EXACT [GOC:mah]
synonym: "establishment of protein localization in membrane" EXACT [GOC:curators]
is_a: GO:0045184 ! establishment of protein localization
relationship: part_of GO:0072657 ! protein localization to membrane
created_by: tanyaberardini
creation_date: 2009-12-08T03:18:51Z

[Term]
id: GO:0090151
name: establishment of protein localization to mitochondrial membrane
namespace: biological_process
def: "The directed movement of a protein to a specific location in the mitochondrial membrane." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "establishment of protein localisation in mitochondrial membrane" EXACT [GOC:mah]
synonym: "establishment of protein localization in mitochondrial membrane" EXACT [GOC:curators]
is_a: GO:0007006 ! mitochondrial membrane organization
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0072655 ! establishment of protein localization to mitochondrion
is_a: GO:0090150 ! establishment of protein localization to membrane
is_a: GO:1902578 ! single-organism localization
created_by: tanyaberardini
creation_date: 2009-12-08T03:18:51Z

[Term]
id: GO:0090152
name: establishment of protein localization to mitochondrial membrane involved in mitochondrial fission
namespace: biological_process
def: "The directed movement of a protein to a specific location in the mitochondrial membrane that contributes to mitochondrial fission." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "establishment of protein localisation in mitochondrial membrane involved in mitochondrial fission" EXACT [GOC:mah]
synonym: "establishment of protein localization in mitochondrial membrane involved in mitochondrial fission" EXACT [GOC:curators]
is_a: GO:0090151 ! establishment of protein localization to mitochondrial membrane
intersection_of: GO:0090151 ! establishment of protein localization to mitochondrial membrane
intersection_of: part_of GO:0000266 ! mitochondrial fission
relationship: part_of GO:0000266 ! mitochondrial fission
created_by: tanyaberardini
creation_date: 2009-12-08T03:18:51Z

[Term]
id: GO:0090153
name: regulation of sphingolipid biosynthetic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0046890 ! regulation of lipid biosynthetic process
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
is_a: GO:1905038 ! regulation of membrane lipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030148 ! sphingolipid biosynthetic process
relationship: regulates GO:0030148 ! sphingolipid biosynthetic process
created_by: tanyaberardini
creation_date: 2009-12-08T03:25:49Z

[Term]
id: GO:0090154
name: positive regulation of sphingolipid biosynthetic process
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0046889 ! positive regulation of lipid biosynthetic process
is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process
is_a: GO:0090153 ! regulation of sphingolipid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030148 ! sphingolipid biosynthetic process
relationship: positively_regulates GO:0030148 ! sphingolipid biosynthetic process
created_by: tanyaberardini
creation_date: 2009-12-08T03:27:33Z

[Term]
id: GO:0090155
name: negative regulation of sphingolipid biosynthetic process
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0051055 ! negative regulation of lipid biosynthetic process
is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process
is_a: GO:0090153 ! regulation of sphingolipid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030148 ! sphingolipid biosynthetic process
relationship: negatively_regulates GO:0030148 ! sphingolipid biosynthetic process
created_by: tanyaberardini
creation_date: 2009-12-08T03:33:39Z

[Term]
id: GO:0090156
name: cellular sphingolipid homeostasis
namespace: biological_process
def: "Any biological process involved in the maintenance of an internal steady state of sphingolipids at the level of the cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0055082 ! cellular chemical homeostasis
is_a: GO:0055088 ! lipid homeostasis
created_by: tanyaberardini
creation_date: 2009-12-08T08:21:36Z

[Term]
id: GO:0090157
name: negative regulation of sphingolipid biosynthesis involved in cellular sphingolipid homeostasis
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of sphingolipid biosynthesis that contributes to the maintenance of an internal equilibrium of sphingolipids at the level of the cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0090155 ! negative regulation of sphingolipid biosynthetic process
created_by: tanyaberardini
creation_date: 2009-12-08T08:22:56Z

[Term]
id: GO:0090158
name: endoplasmic reticulum membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an endoplasmic reticulum membrane." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "endoplasmic reticulum membrane organisation" EXACT [GOC:mah]
is_a: GO:0044802 ! single-organism membrane organization
relationship: part_of GO:0007029 ! endoplasmic reticulum organization
relationship: part_of GO:0010256 ! endomembrane system organization
created_by: tanyaberardini
creation_date: 2009-12-08T08:27:17Z

[Term]
id: GO:0090159
name: sphingolipid biosynthesis involved in endoplasmic reticulum membrane organization
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "sphingolipid biosynthesis involved in endoplasmic reticulum membrane organisation" EXACT [GOC:mah]
is_a: GO:0030148 ! sphingolipid biosynthetic process
intersection_of: GO:0030148 ! sphingolipid biosynthetic process
intersection_of: part_of GO:0090158 ! endoplasmic reticulum membrane organization
relationship: part_of GO:0090158 ! endoplasmic reticulum membrane organization
created_by: tanyaberardini
creation_date: 2009-12-08T08:31:13Z

[Term]
id: GO:0090160
name: Golgi to lysosome transport
namespace: biological_process
def: "The directed movement of substances from the Golgi to lysosomes." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0006896 ! Golgi to vacuole transport
is_a: GO:0007041 ! lysosomal transport
is_a: GO:0016482 ! cytosolic transport
relationship: occurs_in GO:0005829 ! cytosol
created_by: tanyaberardini
creation_date: 2009-12-08T08:35:13Z

[Term]
id: GO:0090161
name: Golgi ribbon formation
namespace: biological_process
def: "The formation of a continuous ribbon of interconnected Golgi stacks of flat cisternae." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0007030 ! Golgi organization
created_by: tanyaberardini
creation_date: 2009-12-08T08:38:14Z

[Term]
id: GO:0090162
name: establishment of epithelial cell polarity
namespace: biological_process
def: "The specification and formation of anisotropic intracellular organization of an epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0030010 ! establishment of cell polarity
created_by: tanyaberardini
creation_date: 2009-12-08T08:58:27Z

[Term]
id: GO:0090163
name: establishment of epithelial cell planar polarity
namespace: biological_process
def: "The specification and formation of the polarity of an epithelial cell along the plane of the epithelial tissue." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0090162 ! establishment of epithelial cell polarity
created_by: tanyaberardini
creation_date: 2009-12-08T08:59:57Z

[Term]
id: GO:0090164
name: asymmetric Golgi ribbon formation
namespace: biological_process
def: "The asymmetric formation of a continuous ribbon of interconnected Golgi stacks of flat cisternae that contributes to the establishment of epithelial cell polarity." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0090161 ! Golgi ribbon formation
relationship: part_of GO:0090162 ! establishment of epithelial cell polarity
created_by: tanyaberardini
creation_date: 2009-12-08T09:02:45Z

[Term]
id: GO:0090165
name: regulation of secretion by asymmetric Golgi ribbon formation
namespace: biological_process
def: "The asymmetric formation of a continuous ribbon of interconnected Golgi stacks of flat cisternae that modulates the controlled release of a substance from a polarized epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0051046 ! regulation of secretion
is_a: GO:0090164 ! asymmetric Golgi ribbon formation
intersection_of: GO:0090164 ! asymmetric Golgi ribbon formation
intersection_of: regulates GO:0046903 ! secretion
relationship: regulates GO:0046903 ! secretion
created_by: tanyaberardini
creation_date: 2009-12-08T09:05:16Z

[Term]
id: GO:0090166
name: Golgi disassembly
namespace: biological_process
def: "A cellular process that results in the breakdown of a Golgi apparatus that contributes to Golgi inheritance." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0007030 ! Golgi organization
is_a: GO:1903008 ! organelle disassembly
relationship: part_of GO:0048313 ! Golgi inheritance
created_by: tanyaberardini
creation_date: 2009-12-08T09:15:11Z

[Term]
id: GO:0090167
name: Golgi distribution to daughter cells
namespace: biological_process
def: "Any process in which disassembled Golgi vesicles are localized into daughter cells upon cell division." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0007030 ! Golgi organization
is_a: GO:0051645 ! Golgi localization
is_a: GO:1902580 ! single-organism cellular localization
is_a: GO:1902589 ! single-organism organelle organization
relationship: part_of GO:0048313 ! Golgi inheritance
created_by: tanyaberardini
creation_date: 2009-12-08T09:15:11Z

[Term]
id: GO:0090168
name: Golgi reassembly
namespace: biological_process
def: "The reformation of the Golgi following its breakdown and partitioning contributing to Golgi inheritance." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0007030 ! Golgi organization
is_a: GO:0022607 ! cellular component assembly
relationship: part_of GO:0048313 ! Golgi inheritance
created_by: tanyaberardini
creation_date: 2009-12-08T09:15:11Z

[Term]
id: GO:0090169
name: regulation of spindle assembly
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of spindle assembly. Spindle assembly is the aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "regulation of spindle formation" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0043254 ! regulation of protein complex assembly
is_a: GO:0090224 ! regulation of spindle organization
is_a: GO:1902115 ! regulation of organelle assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051225 ! spindle assembly
relationship: regulates GO:0051225 ! spindle assembly
created_by: tanyaberardini
creation_date: 2009-12-11T10:17:51Z

[Term]
id: GO:0090170
name: regulation of Golgi inheritance
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of Golgi inheritance. Golgi inheritance is the partitioning of Golgi apparatus between daughter cells at cell division." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:1903358 ! regulation of Golgi organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048313 ! Golgi inheritance
relationship: regulates GO:0048313 ! Golgi inheritance
created_by: tanyaberardini
creation_date: 2009-12-11T10:21:59Z

[Term]
id: GO:0090171
name: chondrocyte morphogenesis
namespace: biological_process
def: "The process in which the structures of a chondrocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a chondrocyte." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0000904 ! cell morphogenesis involved in differentiation
relationship: part_of GO:0002063 ! chondrocyte development
created_by: tanyaberardini
creation_date: 2009-12-11T10:36:02Z

[Term]
id: GO:0090172
name: microtubule cytoskeleton organization involved in homologous chromosome segregation
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins that contributes to chromosomal pairing and precedes synapsis." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "microtubule cytoskeleton organisation involved in homologous chromosome segregation" EXACT [GOC:mah]
synonym: "microtubule organization involved in chromosome pairing" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0000226 ! microtubule cytoskeleton organization
is_a: GO:1903046 ! meiotic cell cycle process
intersection_of: GO:0000226 ! microtubule cytoskeleton organization
intersection_of: part_of GO:0045143 ! homologous chromosome segregation
relationship: part_of GO:0045143 ! homologous chromosome segregation
created_by: tanyaberardini
creation_date: 2009-12-11T11:07:42Z

[Term]
id: GO:0090173
name: regulation of synaptonemal complex assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synaptonemal complex assembly. Synaptonemal complex assembly is the cell cycle process in which the synaptonemal complex, a structure that holds paired chromosomes together during prophase I of meiosis and that promotes genetic recombination, is formed." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0033044 ! regulation of chromosome organization
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0060629 ! regulation of homologous chromosome segregation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007130 ! synaptonemal complex assembly
relationship: regulates GO:0007130 ! synaptonemal complex assembly
created_by: tanyaberardini
creation_date: 2009-12-11T11:40:36Z

[Term]
id: GO:0090174
name: organelle membrane fusion
namespace: biological_process
def: "The joining of two lipid bilayers to form a single organelle membrane." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0044801 ! single-organism membrane fusion
is_a: GO:0048284 ! organelle fusion
is_a: GO:1902589 ! single-organism organelle organization
created_by: tanyaberardini
creation_date: 2009-12-11T11:44:58Z

[Term]
id: GO:0090175
name: regulation of establishment of planar polarity
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the establishment of planar polarity, the coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:2000027 ! regulation of organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001736 ! establishment of planar polarity
relationship: regulates GO:0001736 ! establishment of planar polarity
created_by: tanyaberardini
creation_date: 2009-12-14T10:29:41Z

[Term]
id: GO:0090176
name: microtubule cytoskeleton organization involved in establishment of planar polarity
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins and contributes to the establishment of planar polarity." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "microtubule cytoskeleton organisation involved in establishment of planar polarity" EXACT [GOC:mah]
is_a: GO:0000226 ! microtubule cytoskeleton organization
intersection_of: GO:0000226 ! microtubule cytoskeleton organization
intersection_of: part_of GO:0001736 ! establishment of planar polarity
relationship: part_of GO:0001736 ! establishment of planar polarity
created_by: tanyaberardini
creation_date: 2009-12-14T10:34:25Z

[Term]
id: GO:0090177
name: establishment of planar polarity involved in neural tube closure
namespace: biological_process
def: "Coordinated organization of groups of cells in the plane of an epithelium that contributes to the closure of the neural tube." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0042249 ! establishment of planar polarity of embryonic epithelium
is_a: GO:0048598 ! embryonic morphogenesis
intersection_of: GO:0001736 ! establishment of planar polarity
intersection_of: part_of GO:0001843 ! neural tube closure
relationship: part_of GO:0001843 ! neural tube closure
created_by: tanyaberardini
creation_date: 2009-12-14T10:38:46Z

[Term]
id: GO:0090178
name: regulation of establishment of planar polarity involved in neural tube closure
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the establishment of planar polarity involved in neural tube closure, the coordinated organization of groups of cells in the plane of an epithelium that contributes to the closure of the neural tube." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0045995 ! regulation of embryonic development
is_a: GO:0051960 ! regulation of nervous system development
is_a: GO:0090175 ! regulation of establishment of planar polarity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0090177 ! establishment of planar polarity involved in neural tube closure
relationship: regulates GO:0090177 ! establishment of planar polarity involved in neural tube closure
created_by: tanyaberardini
creation_date: 2009-12-14T11:14:27Z

[Term]
id: GO:0090179
name: planar cell polarity pathway involved in neural tube closure
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors that modulates the establishment of planar polarity contributing to neural tube closure." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway
is_a: GO:0090178 ! regulation of establishment of planar polarity involved in neural tube closure
intersection_of: GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway
intersection_of: part_of GO:0001843 ! neural tube closure
relationship: part_of GO:0001843 ! neural tube closure
created_by: tanyaberardini
creation_date: 2009-12-14T11:20:27Z

[Term]
id: GO:0090180
name: positive regulation of thiamine biosynthetic process
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamine." [GOC:dph, GOC:tb]
synonym: "positive regulation of thiamin biosynthetic process" EXACT [GOC:curators]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0046136 ! positive regulation of vitamin metabolic process
is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process
is_a: GO:0051176 ! positive regulation of sulfur metabolic process
is_a: GO:0070623 ! regulation of thiamine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009228 ! thiamine biosynthetic process
relationship: positively_regulates GO:0009228 ! thiamine biosynthetic process
created_by: tanyaberardini
creation_date: 2009-12-18T10:30:07Z

[Term]
id: GO:0090181
name: regulation of cholesterol metabolic process
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0019218 ! regulation of steroid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008203 ! cholesterol metabolic process
relationship: regulates GO:0008203 ! cholesterol metabolic process
created_by: tanyaberardini
creation_date: 2009-12-18T10:33:49Z

[Term]
id: GO:0090182
name: regulation of secretion of lysosomal enzymes
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of secretion of lysosomal enzymes, the controlled release of lysosomal enzymes by a cell." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0050708 ! regulation of protein secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0033299 ! secretion of lysosomal enzymes
relationship: regulates GO:0033299 ! secretion of lysosomal enzymes
created_by: tanyaberardini
creation_date: 2009-12-18T10:40:46Z

[Term]
id: GO:0090183
name: regulation of kidney development
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:dph, GOC:tb, GOC:yaf]
synonym: "regulation of nephrogenesis" RELATED [GOC:dph, GOC:tb]
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001822 ! kidney development
relationship: regulates GO:0001822 ! kidney development
created_by: tanyaberardini
creation_date: 2009-12-18T10:50:56Z

[Term]
id: GO:0090184
name: positive regulation of kidney development
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:dph, GOC:tb, GOC:yaf]
synonym: "positive regulation of nephrogenesis" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0090183 ! regulation of kidney development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001822 ! kidney development
relationship: positively_regulates GO:0001822 ! kidney development
created_by: tanyaberardini
creation_date: 2009-12-18T10:52:01Z

[Term]
id: GO:0090185
name: negative regulation of kidney development
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:dph, GOC:tb, GOC:yaf]
synonym: "negative regulation of nephrogenesis" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0090183 ! regulation of kidney development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001822 ! kidney development
relationship: negatively_regulates GO:0001822 ! kidney development
created_by: tanyaberardini
creation_date: 2009-12-18T10:58:45Z

[Term]
id: GO:0090186
name: regulation of pancreatic juice secretion
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of pancreatic juice secretion, the regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine." [GOC:dph, GOC:tb]
is_a: GO:0044058 ! regulation of digestive system process
is_a: GO:0050878 ! regulation of body fluid levels
is_a: GO:0051046 ! regulation of secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030157 ! pancreatic juice secretion
relationship: regulates GO:0030157 ! pancreatic juice secretion
created_by: tanyaberardini
creation_date: 2009-12-18T11:03:24Z

[Term]
id: GO:0090187
name: positive regulation of pancreatic juice secretion
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of pancreatic juice secretion, the regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0051047 ! positive regulation of secretion
is_a: GO:0060456 ! positive regulation of digestive system process
is_a: GO:0090186 ! regulation of pancreatic juice secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030157 ! pancreatic juice secretion
relationship: positively_regulates GO:0030157 ! pancreatic juice secretion
created_by: tanyaberardini
creation_date: 2009-12-18T11:03:24Z

[Term]
id: GO:0090188
name: negative regulation of pancreatic juice secretion
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of pancreatic juice secretion, the regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0051048 ! negative regulation of secretion
is_a: GO:0060457 ! negative regulation of digestive system process
is_a: GO:0090186 ! regulation of pancreatic juice secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030157 ! pancreatic juice secretion
relationship: negatively_regulates GO:0030157 ! pancreatic juice secretion
created_by: tanyaberardini
creation_date: 2009-12-18T11:03:24Z

[Term]
id: GO:0090189
name: regulation of branching involved in ureteric bud morphogenesis
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of branching involved in ureteric bud morphogenesis, the process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules." [GOC:dph, GOC:tb, GOC:yaf]
is_a: GO:0060688 ! regulation of morphogenesis of a branching structure
is_a: GO:0061217 ! regulation of mesonephros development
is_a: GO:2000027 ! regulation of organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001658 ! branching involved in ureteric bud morphogenesis
relationship: regulates GO:0001658 ! branching involved in ureteric bud morphogenesis
created_by: tanyaberardini
creation_date: 2009-12-18T11:11:17Z

[Term]
id: GO:0090190
name: positive regulation of branching involved in ureteric bud morphogenesis
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of branching involved in ureteric bud morphogenesis, the process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules." [GOC:dph, GOC:tb, GOC:yaf]
is_a: GO:0061213 ! positive regulation of mesonephros development
is_a: GO:0090189 ! regulation of branching involved in ureteric bud morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001658 ! branching involved in ureteric bud morphogenesis
relationship: positively_regulates GO:0001658 ! branching involved in ureteric bud morphogenesis
created_by: tanyaberardini
creation_date: 2009-12-18T11:11:17Z

[Term]
id: GO:0090191
name: negative regulation of branching involved in ureteric bud morphogenesis
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of branching involved in ureteric bud morphogenesis, the process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules." [GOC:dph, GOC:tb, GOC:yaf]
is_a: GO:0061218 ! negative regulation of mesonephros development
is_a: GO:0090189 ! regulation of branching involved in ureteric bud morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001658 ! branching involved in ureteric bud morphogenesis
relationship: negatively_regulates GO:0001658 ! branching involved in ureteric bud morphogenesis
created_by: tanyaberardini
creation_date: 2009-12-18T11:11:17Z

[Term]
id: GO:0090192
name: regulation of glomerulus development
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of glomerulus development, the progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney." [GOC:dph, GOC:tb, GOC:yaf]
is_a: GO:0090183 ! regulation of kidney development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032835 ! glomerulus development
relationship: regulates GO:0032835 ! glomerulus development
created_by: tanyaberardini
creation_date: 2009-12-18T11:17:13Z

[Term]
id: GO:0090193
name: positive regulation of glomerulus development
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of glomerulus development, the progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney." [GOC:dph, GOC:tb, GOC:yaf]
is_a: GO:0090184 ! positive regulation of kidney development
is_a: GO:0090192 ! regulation of glomerulus development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032835 ! glomerulus development
relationship: positively_regulates GO:0032835 ! glomerulus development
created_by: tanyaberardini
creation_date: 2009-12-18T11:17:13Z

[Term]
id: GO:0090194
name: negative regulation of glomerulus development
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of glomerulus development, the progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney." [GOC:dph, GOC:tb, GOC:yaf]
is_a: GO:0090185 ! negative regulation of kidney development
is_a: GO:0090192 ! regulation of glomerulus development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032835 ! glomerulus development
relationship: negatively_regulates GO:0032835 ! glomerulus development
created_by: tanyaberardini
creation_date: 2009-12-18T11:17:13Z

[Term]
id: GO:0090195
name: chemokine secretion
namespace: biological_process
def: "The regulated release of chemokines from a cell." [GOC:BHF, GOC:rl]
is_a: GO:0050663 ! cytokine secretion
relationship: part_of GO:0032602 ! chemokine production
created_by: tanyaberardini
creation_date: 2009-12-18T11:26:20Z

[Term]
id: GO:0090196
name: regulation of chemokine secretion
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of chemokine secretion, the regulated release of chemokines from a cell." [GOC:BHF, GOC:rl]
is_a: GO:0032642 ! regulation of chemokine production
is_a: GO:0050707 ! regulation of cytokine secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0090195 ! chemokine secretion
relationship: regulates GO:0090195 ! chemokine secretion
created_by: tanyaberardini
creation_date: 2009-12-18T11:28:00Z

[Term]
id: GO:0090197
name: positive regulation of chemokine secretion
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of chemokine secretion, the regulated release of chemokines from a cell." [GOC:BHF, GOC:rl]
is_a: GO:0032722 ! positive regulation of chemokine production
is_a: GO:0050715 ! positive regulation of cytokine secretion
is_a: GO:0090196 ! regulation of chemokine secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0090195 ! chemokine secretion
relationship: positively_regulates GO:0090195 ! chemokine secretion
created_by: tanyaberardini
creation_date: 2009-12-18T11:28:00Z

[Term]
id: GO:0090198
name: negative regulation of chemokine secretion
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of chemokine secretion, the regulated release of chemokines from a cell." [GOC:BHF, GOC:rl]
is_a: GO:0032682 ! negative regulation of chemokine production
is_a: GO:0050710 ! negative regulation of cytokine secretion
is_a: GO:0090196 ! regulation of chemokine secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0090195 ! chemokine secretion
relationship: negatively_regulates GO:0090195 ! chemokine secretion
created_by: tanyaberardini
creation_date: 2009-12-18T11:28:00Z

[Term]
id: GO:0090199
name: regulation of release of cytochrome c from mitochondria
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation." [GOC:dph, GOC:mtg_apoptosis, GOC:tb]
comment: The release of cytochrome c from mitochondria is a central event in the signaling phase of the apoptotic process, and it is often used by researchers to monitor this type of cell death. Any event that induces apoptosis will at some point induce the release of cytochrome c from mitochondria. Therefore, this term should only be used to annotate gene products that directly regulate this process.
is_a: GO:0010821 ! regulation of mitochondrion organization
is_a: GO:2001233 ! regulation of apoptotic signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001836 ! release of cytochrome c from mitochondria
relationship: regulates GO:0001836 ! release of cytochrome c from mitochondria
created_by: tanyaberardini
creation_date: 2009-12-18T11:35:20Z

[Term]
id: GO:0090200
name: positive regulation of release of cytochrome c from mitochondria
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation." [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:tb]
comment: The release of cytochrome c from mitochondria is a central event in the signaling phase of the apoptotic process, and it is often used by researchers to monitor this type of cell death. Any event that induces apoptosis will at some point induce the release of cytochrome c from mitochondria. Therefore, this term should only be used to annotate gene products that directly and positively regulate this process.
is_a: GO:0010822 ! positive regulation of mitochondrion organization
is_a: GO:0090199 ! regulation of release of cytochrome c from mitochondria
is_a: GO:2001235 ! positive regulation of apoptotic signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001836 ! release of cytochrome c from mitochondria
relationship: positively_regulates GO:0001836 ! release of cytochrome c from mitochondria
created_by: tanyaberardini
creation_date: 2009-12-18T11:35:20Z

[Term]
id: GO:0090201
name: negative regulation of release of cytochrome c from mitochondria
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation." [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:tb]
comment: The release of cytochrome c from mitochondria is a central event in the signaling phase of the apoptotic process, and it is often used by researchers to monitor this type of cell death. Any event that induces apoptosis will at some point induce the release of cytochrome c from mitochondria. Therefore, this term should only be used to annotate gene products that directly and negatively regulate this process.
is_a: GO:0010823 ! negative regulation of mitochondrion organization
is_a: GO:0090199 ! regulation of release of cytochrome c from mitochondria
is_a: GO:2001234 ! negative regulation of apoptotic signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001836 ! release of cytochrome c from mitochondria
relationship: negatively_regulates GO:0001836 ! release of cytochrome c from mitochondria
created_by: tanyaberardini
creation_date: 2009-12-18T11:35:20Z

[Term]
id: GO:0090202
name: gene looping
namespace: biological_process
def: "The formation and maintenance of DNA loops that juxtapose sequentially separated regions of RNA polymerase II-transcribed genes." [GOC:dph, GOC:rb, GOC:tb, PMID:19923429, PMID:19933150]
is_a: GO:0006325 ! chromatin organization
is_a: GO:0090579 ! dsDNA loop formation
created_by: tanyaberardini
creation_date: 2009-12-18T11:56:00Z

[Term]
id: GO:0090203
name: transcriptional activation by promoter-terminator looping
namespace: biological_process
def: "The formation and maintenance of DNA loops that juxtapose the promoter and terminator regions of RNA polymerase II-transcribed genes and activate transcription from an RNA polymerase II promoter." [GOC:dph, GOC:rb, GOC:tb]
synonym: "transcriptional activation by memory gene loops" RELATED [GOC:dph, GOC:rb, GOC:tb]
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
is_a: GO:0090202 ! gene looping
created_by: tanyaberardini
creation_date: 2009-12-18T11:58:32Z

[Term]
id: GO:0090204
name: protein localization to nuclear pore
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a nuclear pore." [GOC:dph, GOC:rb, GOC:tb]
synonym: "protein localisation to nuclear pore" EXACT [GOC:mah]
is_a: GO:0072657 ! protein localization to membrane
is_a: GO:0090435 ! protein localization to nuclear envelope
created_by: tanyaberardini
creation_date: 2009-12-18T12:05:01Z

[Term]
id: GO:0090205
name: positive regulation of cholesterol metabolic process
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:dph, GOC:sl, GOC:tb]
is_a: GO:0045940 ! positive regulation of steroid metabolic process
is_a: GO:0090181 ! regulation of cholesterol metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008203 ! cholesterol metabolic process
relationship: positively_regulates GO:0008203 ! cholesterol metabolic process
created_by: tanyaberardini
creation_date: 2009-12-23T10:27:37Z

[Term]
id: GO:0090206
name: negative regulation of cholesterol metabolic process
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:dph, GOC:sl, GOC:tb]
is_a: GO:0045939 ! negative regulation of steroid metabolic process
is_a: GO:0090181 ! regulation of cholesterol metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008203 ! cholesterol metabolic process
relationship: negatively_regulates GO:0008203 ! cholesterol metabolic process
created_by: tanyaberardini
creation_date: 2009-12-23T10:27:37Z

[Term]
id: GO:0090207
name: regulation of triglyceride metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol." [GOC:dph, GOC:sl, GOC:tb]
is_a: GO:0019216 ! regulation of lipid metabolic process
is_a: GO:0031323 ! regulation of cellular metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006641 ! triglyceride metabolic process
relationship: regulates GO:0006641 ! triglyceride metabolic process
created_by: tanyaberardini
creation_date: 2009-12-23T10:35:06Z

[Term]
id: GO:0090208
name: positive regulation of triglyceride metabolic process
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol." [GOC:dph, GOC:sl, GOC:tb]
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0045834 ! positive regulation of lipid metabolic process
is_a: GO:0090207 ! regulation of triglyceride metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006641 ! triglyceride metabolic process
relationship: positively_regulates GO:0006641 ! triglyceride metabolic process
created_by: tanyaberardini
creation_date: 2009-12-23T10:35:06Z

[Term]
id: GO:0090209
name: negative regulation of triglyceride metabolic process
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol." [GOC:dph, GOC:sl, GOC:tb]
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0045833 ! negative regulation of lipid metabolic process
is_a: GO:0090207 ! regulation of triglyceride metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006641 ! triglyceride metabolic process
relationship: negatively_regulates GO:0006641 ! triglyceride metabolic process
created_by: tanyaberardini
creation_date: 2009-12-23T10:35:06Z

[Term]
id: GO:0090210
name: regulation of establishment of blood-brain barrier
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the establishment of the blood-brain barrier, a selectively permeable structural and functional barrier that exists between the capillaries and the brain." [GOC:dph, GOC:tb]
synonym: "regulation of establishment of BBB" EXACT [PMID:20080302]
is_a: GO:0060284 ! regulation of cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060856 ! establishment of blood-brain barrier
relationship: regulates GO:0060856 ! establishment of blood-brain barrier
created_by: tanyaberardini
creation_date: 2009-12-23T12:15:53Z

[Term]
id: GO:0090211
name: positive regulation of establishment of blood-brain barrier
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the establishment of the blood-brain barrier, a selectively permeable structural and functional barrier that exists between the capillaries and the brain." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "positive regulation of establishment of BBB" EXACT [PMID:20080302]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0090210 ! regulation of establishment of blood-brain barrier
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060856 ! establishment of blood-brain barrier
relationship: positively_regulates GO:0060856 ! establishment of blood-brain barrier
created_by: tanyaberardini
creation_date: 2009-12-23T12:15:53Z

[Term]
id: GO:0090212
name: negative regulation of establishment of blood-brain barrier
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the establishment of the blood-brain barrier, a selectively permeable structural and functional barrier that exists between the capillaries and the brain." [GOC:dph, GOC:tb]
synonym: "negative regulation of establishment of BBB" EXACT [PMID:20080302]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0090210 ! regulation of establishment of blood-brain barrier
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060856 ! establishment of blood-brain barrier
relationship: negatively_regulates GO:0060856 ! establishment of blood-brain barrier
created_by: tanyaberardini
creation_date: 2009-12-23T12:15:53Z

[Term]
id: GO:0090213
name: regulation of radial pattern formation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of radial pattern formation, the regionalization process that results in defined areas around a point in which specific types of cell differentiation will occur." [GOC:tb]
synonym: "regulation of radial pattern specification" NARROW [GOC:tb]
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009956 ! radial pattern formation
relationship: regulates GO:0009956 ! radial pattern formation
created_by: tanyaberardini
creation_date: 2010-01-05T10:59:10Z

[Term]
id: GO:0090214
name: spongiotrophoblast layer developmental growth
namespace: biological_process
def: "The increase in size or mass of the spongiotrophoblast layer of the placenta where the increase in size or mass contributes to the progression of that layer over time from its formation to its mature state." [GOC:dph, GOC:tb]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0048589 ! developmental growth
relationship: part_of GO:0060712 ! spongiotrophoblast layer development
created_by: tanyaberardini
creation_date: 2010-01-08T12:10:44Z

[Term]
id: GO:0090215
name: regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate." [GOC:dph, GOC:tb]
is_a: GO:0043550 ! regulation of lipid kinase activity
is_a: GO:1903725 ! regulation of phospholipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016308 ! 1-phosphatidylinositol-4-phosphate 5-kinase activity
relationship: regulates GO:0016308 ! 1-phosphatidylinositol-4-phosphate 5-kinase activity
created_by: tanyaberardini
creation_date: 2010-01-12T10:00:45Z

[Term]
id: GO:0090216
name: positive regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate." [GOC:dph, GOC:tb]
is_a: GO:0090215 ! regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity
is_a: GO:0090218 ! positive regulation of lipid kinase activity
is_a: GO:1903727 ! positive regulation of phospholipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016308 ! 1-phosphatidylinositol-4-phosphate 5-kinase activity
relationship: positively_regulates GO:0016308 ! 1-phosphatidylinositol-4-phosphate 5-kinase activity
created_by: tanyaberardini
creation_date: 2010-01-12T10:00:45Z

[Term]
id: GO:0090217
name: negative regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate." [GOC:dph, GOC:tb]
is_a: GO:0090215 ! regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity
is_a: GO:0090219 ! negative regulation of lipid kinase activity
is_a: GO:1903726 ! negative regulation of phospholipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016308 ! 1-phosphatidylinositol-4-phosphate 5-kinase activity
relationship: negatively_regulates GO:0016308 ! 1-phosphatidylinositol-4-phosphate 5-kinase activity
created_by: tanyaberardini
creation_date: 2010-01-12T10:00:45Z

[Term]
id: GO:0090218
name: positive regulation of lipid kinase activity
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid." [GOC:dph, GOC:tb]
is_a: GO:0033674 ! positive regulation of kinase activity
is_a: GO:0043550 ! regulation of lipid kinase activity
is_a: GO:0045834 ! positive regulation of lipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001727 ! lipid kinase activity
relationship: positively_regulates GO:0001727 ! lipid kinase activity
created_by: tanyaberardini
creation_date: 2010-01-12T10:18:30Z

[Term]
id: GO:0090219
name: negative regulation of lipid kinase activity
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid." [GOC:dph, GOC:tb]
is_a: GO:0033673 ! negative regulation of kinase activity
is_a: GO:0043550 ! regulation of lipid kinase activity
is_a: GO:0045833 ! negative regulation of lipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001727 ! lipid kinase activity
relationship: negatively_regulates GO:0001727 ! lipid kinase activity
created_by: tanyaberardini
creation_date: 2010-01-12T10:18:30Z

[Term]
id: GO:0090220
name: chromosome localization to nuclear envelope involved in homologous chromosome segregation
namespace: biological_process
def: "The directed movement of a chromosome to the nuclear envelope that contributes to homologous chromosome segregation and precedes synapsis." [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:19913287]
synonym: "chromosome localisation to nuclear envelope involved in homologous chromosome segregation" EXACT [GOC:mah]
is_a: GO:0022414 ! reproductive process
is_a: GO:0051303 ! establishment of chromosome localization
relationship: part_of GO:0045143 ! homologous chromosome segregation
created_by: tanyaberardini
creation_date: 2010-01-13T10:20:33Z

[Term]
id: GO:0090221
name: mitotic spindle-templated microtubule nucleation
namespace: biological_process
def: "The 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates from within the mitotic spindle." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0007020 ! microtubule nucleation
created_by: tanyaberardini
creation_date: 2010-01-13T10:42:37Z

[Term]
id: GO:0090222
name: centrosome-templated microtubule nucleation
namespace: biological_process
def: "The 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates from the centrosome." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0007020 ! microtubule nucleation
created_by: tanyaberardini
creation_date: 2010-01-13T10:52:36Z

[Term]
id: GO:0090223
name: chromatin-templated microtubule nucleation
namespace: biological_process
def: "The 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates from chromatin." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0007020 ! microtubule nucleation
created_by: tanyaberardini
creation_date: 2010-01-13T10:53:35Z

[Term]
id: GO:0090224
name: regulation of spindle organization
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "regulation of spindle organisation" EXACT [GOC:mah]
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0031114 ! regulation of microtubule depolymerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007051 ! spindle organization
relationship: regulates GO:0007051 ! spindle organization
created_by: tanyaberardini
creation_date: 2010-01-13T11:04:53Z

[Term]
id: GO:0090225
name: regulation of spindle density
namespace: biological_process
def: "Any process that modulates the number of microtubules in a given region of the spindle." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0065008 ! regulation of biological quality
is_a: GO:0090224 ! regulation of spindle organization
created_by: tanyaberardini
creation_date: 2010-01-13T11:24:53Z

[Term]
id: GO:0090226
name: regulation of microtubule nucleation by Ran protein signal transduction
namespace: biological_process
def: "Any series of molecular signals in which a Ran GTPase relays one or more of the signals resulting in the modulation of the rate, frequency or extent of microtubule nucleation." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0010968 ! regulation of microtubule nucleation
is_a: GO:0031291 ! Ran protein signal transduction
intersection_of: GO:0031291 ! Ran protein signal transduction
intersection_of: regulates GO:0007020 ! microtubule nucleation
relationship: regulates GO:0007020 ! microtubule nucleation
created_by: tanyaberardini
creation_date: 2010-01-13T11:35:31Z

[Term]
id: GO:0090227
name: regulation of red or far-red light signaling pathway
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the red or far-red signaling pathway, the series of molecular signals initiated upon sensing by photoreceptor molecules of red light or far red light." [GOC:tb]
synonym: "regulation of phytochrome signaling pathway" EXACT [GOC:tb]
synonym: "regulation of red or far-red light signalling pathway" EXACT [GOC:mah]
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:2000030 ! regulation of response to red or far red light
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010017 ! red or far-red light signaling pathway
relationship: regulates GO:0010017 ! red or far-red light signaling pathway
created_by: tanyaberardini
creation_date: 2010-01-19T04:03:29Z

[Term]
id: GO:0090228
name: positive regulation of red or far-red light signaling pathway
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the red or far-red signaling pathway, the series of molecular signals initiated upon sensing by photoreceptor molecules of red light or far red light." [GOC:tb]
synonym: "positive regulation of phytochrome signaling pathway" EXACT [GOC:tb]
synonym: "positive regulation of red or far-red light signalling pathway" EXACT [GOC:mah]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0090227 ! regulation of red or far-red light signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010017 ! red or far-red light signaling pathway
relationship: positively_regulates GO:0010017 ! red or far-red light signaling pathway
created_by: tanyaberardini
creation_date: 2010-01-19T04:03:29Z

[Term]
id: GO:0090229
name: negative regulation of red or far-red light signaling pathway
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the red or far-red signaling pathway, the series of molecular signals initiated upon sensing by photoreceptor molecules of red light or far red light." [GOC:tb]
synonym: "negative regulation of phytochrome signaling pathway" EXACT [GOC:tb]
synonym: "negative regulation of red or far-red light signalling pathway" EXACT [GOC:mah]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0090227 ! regulation of red or far-red light signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010017 ! red or far-red light signaling pathway
relationship: negatively_regulates GO:0010017 ! red or far-red light signaling pathway
created_by: tanyaberardini
creation_date: 2010-01-19T04:03:29Z

[Term]
id: GO:0090230
name: regulation of centromere complex assembly
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of centromere complex assembly, the aggregation, arrangement and bonding together of proteins and centromeric DNA molecules to form a centromeric protein-DNA complex." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "centromere licensing" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0033044 ! regulation of chromosome organization
is_a: GO:0044087 ! regulation of cellular component biogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034508 ! centromere complex assembly
relationship: regulates GO:0034508 ! centromere complex assembly
created_by: tanyaberardini
creation_date: 2010-01-20T10:20:49Z

[Term]
id: GO:0090231
name: regulation of spindle checkpoint
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle." [GOC:ascb_2009, GOC:dph, GOC:tb]
comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of checkpoint (i.e mitotic spindle or DNA damage etc).
subset: gocheck_do_not_manually_annotate
is_a: GO:1901976 ! regulation of cell cycle checkpoint
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031577 ! spindle checkpoint
relationship: regulates GO:0031577 ! spindle checkpoint
created_by: tanyaberardini
creation_date: 2010-01-20T10:29:43Z

[Term]
id: GO:0090232
name: positive regulation of spindle checkpoint
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle." [GOC:ascb_2009, GOC:dph, GOC:tb]
subset: gocheck_do_not_manually_annotate
synonym: "spindle checkpoint activation" NARROW [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0090231 ! regulation of spindle checkpoint
is_a: GO:1901978 ! positive regulation of cell cycle checkpoint
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0031577 ! spindle checkpoint
relationship: positively_regulates GO:0031577 ! spindle checkpoint
created_by: tanyaberardini
creation_date: 2010-01-20T10:29:43Z

[Term]
id: GO:0090233
name: negative regulation of spindle checkpoint
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle." [GOC:ascb_2009, GOC:dph, GOC:tb]
comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of checkpoint (i.e mitotic spindle or DNA damage etc).
subset: gocheck_do_not_manually_annotate
synonym: "spindle checkpoint silencing" NARROW [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0090231 ! regulation of spindle checkpoint
is_a: GO:1901977 ! negative regulation of cell cycle checkpoint
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0031577 ! spindle checkpoint
relationship: negatively_regulates GO:0031577 ! spindle checkpoint
created_by: tanyaberardini
creation_date: 2010-01-20T10:29:43Z

[Term]
id: GO:0090234
name: regulation of kinetochore assembly
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of kinetochore assembly, the aggregation, arrangement and bonding together of a set of components to form the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "regulation of chromosome-kinetochore attachment" NARROW [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0043254 ! regulation of protein complex assembly
is_a: GO:0051983 ! regulation of chromosome segregation
is_a: GO:0090230 ! regulation of centromere complex assembly
is_a: GO:1902115 ! regulation of organelle assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051382 ! kinetochore assembly
relationship: regulates GO:0051382 ! kinetochore assembly
created_by: tanyaberardini
creation_date: 2010-01-20T10:46:56Z

[Term]
id: GO:0090235
name: regulation of metaphase plate congression
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of metaphase plate congression, the alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the spindle." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "regulation of chromosome congression" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0051983 ! regulation of chromosome segregation
is_a: GO:0060341 ! regulation of cellular localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051310 ! metaphase plate congression
relationship: regulates GO:0051310 ! metaphase plate congression
created_by: tanyaberardini
creation_date: 2010-01-20T11:05:55Z

[Term]
id: GO:0090236
name: regulation of transcription from RNA polymerase II promoter involved in somitogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
intersection_of: part_of GO:0001756 ! somitogenesis
relationship: part_of GO:0001756 ! somitogenesis
created_by: tanyaberardini
creation_date: 2010-01-20T11:12:29Z

[Term]
id: GO:0090237
name: regulation of arachidonic acid secretion
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of arachidonic acid secretion, the controlled release of arachidonic acid from a cell or a tissue." [GOC:dph, GOC:tb]
is_a: GO:0032303 ! regulation of icosanoid secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050482 ! arachidonic acid secretion
relationship: regulates GO:0050482 ! arachidonic acid secretion
created_by: tanyaberardini
creation_date: 2010-01-20T03:32:22Z

[Term]
id: GO:0090238
name: positive regulation of arachidonic acid secretion
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of arachidonic acid secretion, the controlled release of arachidonic acid from a cell or a tissue." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0032305 ! positive regulation of icosanoid secretion
is_a: GO:0090237 ! regulation of arachidonic acid secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0050482 ! arachidonic acid secretion
relationship: positively_regulates GO:0050482 ! arachidonic acid secretion
created_by: tanyaberardini
creation_date: 2010-01-20T03:32:22Z

[Term]
id: GO:0090239
name: regulation of histone H4 acetylation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of histone H4 acetylation, the modification of histone H4 by the addition of an acetyl group." [GOC:dph, GOC:tb]
is_a: GO:0035065 ! regulation of histone acetylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043967 ! histone H4 acetylation
relationship: regulates GO:0043967 ! histone H4 acetylation
created_by: tanyaberardini
creation_date: 2010-01-20T03:48:09Z

[Term]
id: GO:0090240
name: positive regulation of histone H4 acetylation
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of histone H4 acetylation, the modification of histone H4 by the addition of an acetyl group." [GOC:dph, GOC:tb]
is_a: GO:0035066 ! positive regulation of histone acetylation
is_a: GO:0090239 ! regulation of histone H4 acetylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043967 ! histone H4 acetylation
relationship: positively_regulates GO:0043967 ! histone H4 acetylation
created_by: tanyaberardini
creation_date: 2010-01-20T03:48:09Z

[Term]
id: GO:0090241
name: negative regulation of histone H4 acetylation
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of histone H4 acetylation, the modification of histone H4 by the addition of an acetyl group." [GOC:dph, GOC:tb]
is_a: GO:0035067 ! negative regulation of histone acetylation
is_a: GO:0090239 ! regulation of histone H4 acetylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043967 ! histone H4 acetylation
relationship: negatively_regulates GO:0043967 ! histone H4 acetylation
created_by: tanyaberardini
creation_date: 2010-01-20T03:48:09Z

[Term]
id: GO:0090242
name: retinoic acid receptor signaling pathway involved in somitogenesis
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that contributes to somitogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "retinoic acid receptor signalling pathway involved in somitogenesis" EXACT [GOC:mah]
is_a: GO:0048384 ! retinoic acid receptor signaling pathway
intersection_of: GO:0048384 ! retinoic acid receptor signaling pathway
intersection_of: part_of GO:0001756 ! somitogenesis
relationship: part_of GO:0001756 ! somitogenesis
created_by: tanyaberardini
creation_date: 2010-01-22T10:42:54Z

[Term]
id: GO:0090243
name: fibroblast growth factor receptor signaling pathway involved in somitogenesis
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to somitogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "fibroblast growth factor receptor signalling pathway involved in somitogenesis" EXACT [GOC:mah]
is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway
intersection_of: GO:0008543 ! fibroblast growth factor receptor signaling pathway
intersection_of: part_of GO:0001756 ! somitogenesis
relationship: part_of GO:0001756 ! somitogenesis
created_by: tanyaberardini
creation_date: 2010-01-22T10:46:15Z

[Term]
id: GO:0090244
name: Wnt signaling pathway involved in somitogenesis
namespace: biological_process
def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state that contributes to somitogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "Wnt receptor signaling pathway involved in somitogenesis" EXACT []
synonym: "Wnt receptor signalling" EXACT [GOC:mah]
synonym: "Wnt-activated signaling pathway involved in somitogenesis" EXACT [GOC:signaling]
is_a: GO:0016055 ! Wnt signaling pathway
intersection_of: GO:0016055 ! Wnt signaling pathway
intersection_of: part_of GO:0001756 ! somitogenesis
relationship: part_of GO:0001756 ! somitogenesis
created_by: tanyaberardini
creation_date: 2010-01-22T10:47:59Z

[Term]
id: GO:0090245
name: axis elongation involved in somitogenesis
namespace: biological_process
def: "The developmental growth that results in the elongation of the rostral-caudal axis that contributes to somitogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003401 ! axis elongation
intersection_of: GO:0003401 ! axis elongation
intersection_of: part_of GO:0001756 ! somitogenesis
relationship: part_of GO:0001756 ! somitogenesis
created_by: tanyaberardini
creation_date: 2010-01-22T10:54:29Z

[Term]
id: GO:0090246
name: convergent extension involved in somitogenesis
namespace: biological_process
def: "The morphogenetic process in which a presomitic mesoderm narrows along the left-right axis and lengthens in the rostral-caudal axis contributing to somitogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0060027 ! convergent extension involved in gastrulation
is_a: GO:0060028 ! convergent extension involved in axis elongation
intersection_of: GO:0060026 ! convergent extension
intersection_of: part_of GO:0001756 ! somitogenesis
relationship: part_of GO:0001756 ! somitogenesis
relationship: part_of GO:0090245 ! axis elongation involved in somitogenesis
created_by: tanyaberardini
creation_date: 2010-01-22T10:59:06Z

[Term]
id: GO:0090247
name: cell motility involved in somitogenic axis elongation
namespace: biological_process
def: "Any process involved in the controlled self-propelled movement of a cell that contributes to somitogenic axis elongation." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0048870 ! cell motility
intersection_of: GO:0048870 ! cell motility
intersection_of: part_of GO:0090245 ! axis elongation involved in somitogenesis
relationship: part_of GO:0090245 ! axis elongation involved in somitogenesis
created_by: tanyaberardini
creation_date: 2010-01-22T11:07:17Z

[Term]
id: GO:0090248
name: cell migration involved in somitogenic axis elongation
namespace: biological_process
def: "The orderly movement of a presomitic mesoderm cell that contributes to somitogenic axis elongation." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0016477 ! cell migration
is_a: GO:0090247 ! cell motility involved in somitogenic axis elongation
intersection_of: GO:0016477 ! cell migration
intersection_of: part_of GO:0090245 ! axis elongation involved in somitogenesis
relationship: part_of GO:0090245 ! axis elongation involved in somitogenesis
created_by: tanyaberardini
creation_date: 2010-01-22T11:13:59Z

[Term]
id: GO:0090249
name: regulation of cell motility involved in somitogenic axis elongation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the controlled self-propelled movement of a cell that contributes to somitogenic axis elongation." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0014807 ! regulation of somitogenesis
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:2000145 ! regulation of cell motility
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0090247 ! cell motility involved in somitogenic axis elongation
relationship: regulates GO:0090247 ! cell motility involved in somitogenic axis elongation
created_by: tanyaberardini
creation_date: 2010-01-22T11:20:05Z

[Term]
id: GO:0090250
name: cell-cell adhesion involved in establishment of planar polarity
namespace: biological_process
def: "The attachment of one cell to another cell via adhesion molecules that contributes to the establishment of planar cell polarity." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0016337 ! single organismal cell-cell adhesion
is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules
intersection_of: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules
intersection_of: part_of GO:0001736 ! establishment of planar polarity
relationship: part_of GO:0001736 ! establishment of planar polarity
created_by: tanyaberardini
creation_date: 2010-01-22T11:28:03Z

[Term]
id: GO:0090251
name: protein localization involved in establishment of planar polarity
namespace: biological_process
def: "Any process in which a protein is transported to, and/or maintained in, a specific location in a cell that contributes to the establishment of planar polarity." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "protein localisation involved in establishment of planar polarity" EXACT [GOC:mah]
is_a: GO:0034613 ! cellular protein localization
intersection_of: GO:0008104 ! protein localization
intersection_of: part_of GO:0001736 ! establishment of planar polarity
relationship: part_of GO:0001736 ! establishment of planar polarity
created_by: tanyaberardini
creation_date: 2010-01-22T11:31:32Z

[Term]
id: GO:0090252
name: epithelium migration involved in imaginal disc-derived wing morphogenesis
namespace: biological_process
def: "The process in which the population of cells that make up a wing epithelium undergo directed movement and contribute to imaginal disc-derived morphogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0090132 ! epithelium migration
intersection_of: GO:0090132 ! epithelium migration
intersection_of: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis
relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis
created_by: tanyaberardini
creation_date: 2010-01-22T11:40:46Z

[Term]
id: GO:0090253
name: convergent extension involved in imaginal disc-derived wing morphogenesis
namespace: biological_process
def: "The morphogenetic process in which the wing epithelium narrows along one axis and lengthens in a perpendicular axis that contributes to imaginal disc-derived wing morphogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0009886 ! post-embryonic morphogenesis
is_a: GO:0060029 ! convergent extension involved in organogenesis
intersection_of: GO:0060026 ! convergent extension
intersection_of: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis
relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis
created_by: tanyaberardini
creation_date: 2010-01-22T11:40:46Z

[Term]
id: GO:0090254
name: cell elongation involved in imaginal disc-derived wing morphogenesis
namespace: biological_process
def: "The process in which a cell elongates and contributes to imaginal disc-derived wing morphogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0009826 ! unidimensional cell growth
is_a: GO:0009886 ! post-embryonic morphogenesis
intersection_of: GO:0009826 ! unidimensional cell growth
intersection_of: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis
relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis
created_by: tanyaberardini
creation_date: 2010-01-22T11:40:46Z

[Term]
id: GO:0090255
name: cell proliferation involved in imaginal disc-derived wing morphogenesis
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to imaginal disc-derived wing morphogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0008283 ! cell proliferation
intersection_of: GO:0008283 ! cell proliferation
intersection_of: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis
relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis
created_by: tanyaberardini
creation_date: 2010-01-22T11:40:46Z

[Term]
id: GO:0090256
name: regulation of cell proliferation involved in imaginal disc-derived wing morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to imaginal disc-derived wing morphogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0042127 ! regulation of cell proliferation
is_a: GO:0048580 ! regulation of post-embryonic development
is_a: GO:2000027 ! regulation of organ morphogenesis
intersection_of: GO:0042127 ! regulation of cell proliferation
intersection_of: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis
relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis
relationship: regulates GO:0090255 ! cell proliferation involved in imaginal disc-derived wing morphogenesis
created_by: tanyaberardini
creation_date: 2010-01-22T11:40:46Z

[Term]
id: GO:0090257
name: regulation of muscle system process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system." [GOC:dph, GOC:tb]
is_a: GO:0044057 ! regulation of system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003012 ! muscle system process
relationship: regulates GO:0003012 ! muscle system process
created_by: tanyaberardini
creation_date: 2010-02-03T11:48:13Z

[Term]
id: GO:0090258
name: negative regulation of mitochondrial fission
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [GOC:sl, GOC:tb]
synonym: "negative regulation of mitochondrial division" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010823 ! negative regulation of mitochondrion organization
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0090140 ! regulation of mitochondrial fission
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000266 ! mitochondrial fission
relationship: negatively_regulates GO:0000266 ! mitochondrial fission
created_by: tanyaberardini
creation_date: 2010-02-03T04:05:32Z

[Term]
id: GO:0090259
name: regulation of retinal ganglion cell axon guidance
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of retinal ganglion cell axon guidance, the process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:tb, GOC:yaf]
is_a: GO:1902667 ! regulation of axon guidance
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031290 ! retinal ganglion cell axon guidance
relationship: regulates GO:0031290 ! retinal ganglion cell axon guidance
created_by: tanyaberardini
creation_date: 2010-02-03T04:13:59Z

[Term]
id: GO:0090260
name: negative regulation of retinal ganglion cell axon guidance
namespace: biological_process
def: "Any process that decreases the frequency, rate, or extent of retinal ganglion cell axon guidance, the process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:tb, GOC:yaf]
comment: Note that growth cone collapse has been observed only in assays performed in vitro.
synonym: "axon growth cone collapse" RELATED [GOC:curators]
is_a: GO:0090259 ! regulation of retinal ganglion cell axon guidance
is_a: GO:1902668 ! negative regulation of axon guidance
intersection_of: GO:0048519 ! negative regulation of biological process
intersection_of: negatively_regulates GO:0031290 ! retinal ganglion cell axon guidance
relationship: negatively_regulates GO:0031290 ! retinal ganglion cell axon guidance
created_by: tanyaberardini
creation_date: 2010-02-03T04:13:59Z

[Term]
id: GO:0090261
name: positive regulation of inclusion body assembly
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of inclusion body assembly. Inclusion body assembly is the aggregation, arrangement and bonding together of a set of components to form an inclusion body." [GOC:tb]
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:0090083 ! regulation of inclusion body assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070841 ! inclusion body assembly
relationship: positively_regulates GO:0070841 ! inclusion body assembly
created_by: tanyaberardini
creation_date: 2010-02-03T04:23:54Z

[Term]
id: GO:0090262
name: regulation of transcription-coupled nucleotide-excision repair
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway." [GOC:tb]
is_a: GO:2000819 ! regulation of nucleotide-excision repair
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006283 ! transcription-coupled nucleotide-excision repair
relationship: regulates GO:0006283 ! transcription-coupled nucleotide-excision repair
created_by: tanyaberardini
creation_date: 2010-02-03T04:27:42Z

[Term]
id: GO:0090263
name: positive regulation of canonical Wnt signaling pathway
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:tb]
synonym: "positive regulation of canonical Wnt receptor signaling pathway" EXACT []
synonym: "positive regulation of canonical Wnt receptor signalling pathway" EXACT [GOC:mah]
synonym: "positive regulation of canonical Wnt-activated signaling pathway" EXACT [GOC:signaling]
synonym: "positive regulation of Wnt receptor signaling pathway through beta-catenin" EXACT [GOC:mtg_signal]
is_a: GO:0030177 ! positive regulation of Wnt signaling pathway
is_a: GO:0060828 ! regulation of canonical Wnt signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060070 ! canonical Wnt signaling pathway
relationship: positively_regulates GO:0060070 ! canonical Wnt signaling pathway
created_by: tanyaberardini
creation_date: 2010-02-03T04:32:16Z

[Term]
id: GO:0090264
name: regulation of immune complex clearance by monocytes and macrophages
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the process of immune complex clearance by monocytes or macrophages." [GOC:tb]
is_a: GO:0002697 ! regulation of immune effector process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002436 ! immune complex clearance by monocytes and macrophages
relationship: regulates GO:0002436 ! immune complex clearance by monocytes and macrophages
created_by: tanyaberardini
creation_date: 2010-02-04T04:31:29Z

[Term]
id: GO:0090265
name: positive regulation of immune complex clearance by monocytes and macrophages
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the process of immune complex clearance by monocytes or macrophages." [GOC:BHF]
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0090264 ! regulation of immune complex clearance by monocytes and macrophages
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002436 ! immune complex clearance by monocytes and macrophages
relationship: positively_regulates GO:0002436 ! immune complex clearance by monocytes and macrophages
created_by: tanyaberardini
creation_date: 2010-02-04T04:32:18Z

[Term]
id: GO:0090266
name: regulation of mitotic cell cycle spindle assembly checkpoint
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the mitotic cell cycle spindle assembly checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle." [GOC:mtg_cell_cycle]
is_a: GO:0051340 ! regulation of ligase activity
is_a: GO:1903504 ! regulation of mitotic spindle checkpoint
is_a: GO:1904666 ! regulation of ubiquitin protein ligase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007094 ! mitotic spindle assembly checkpoint
relationship: regulates GO:0007094 ! mitotic spindle assembly checkpoint
created_by: tanyaberardini
creation_date: 2010-02-05T02:06:37Z

[Term]
id: GO:0090267
name: positive regulation of mitotic cell cycle spindle assembly checkpoint
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the mitotic cell cycle spindle assembly checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle." [GOC:mah, GOC:vw]
is_a: GO:0045931 ! positive regulation of mitotic cell cycle
is_a: GO:0090232 ! positive regulation of spindle checkpoint
is_a: GO:0090266 ! regulation of mitotic cell cycle spindle assembly checkpoint
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007094 ! mitotic spindle assembly checkpoint
relationship: positively_regulates GO:0007094 ! mitotic spindle assembly checkpoint
created_by: tanyaberardini
creation_date: 2010-02-05T02:09:44Z

[Term]
id: GO:0090268
name: activation of mitotic cell cycle spindle assembly checkpoint
namespace: biological_process
def: "Any process that starts the inactive process of a mitotic cell cycle spindle assembly checkpoint." [GOC:mah, GOC:vw]
is_a: GO:0090267 ! positive regulation of mitotic cell cycle spindle assembly checkpoint
created_by: tanyaberardini
creation_date: 2010-02-05T02:09:44Z

[Term]
id: GO:0090269
name: fibroblast growth factor production
namespace: biological_process
def: "The appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF]
is_a: GO:0001816 ! cytokine production
created_by: tanyaberardini
creation_date: 2010-02-05T02:33:33Z

[Term]
id: GO:0090270
name: regulation of fibroblast growth factor production
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF]
is_a: GO:0001816 ! cytokine production
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0090269 ! fibroblast growth factor production
relationship: regulates GO:0090269 ! fibroblast growth factor production
created_by: tanyaberardini
creation_date: 2010-02-05T02:33:33Z

[Term]
id: GO:0090271
name: positive regulation of fibroblast growth factor production
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF]
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0090270 ! regulation of fibroblast growth factor production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0090269 ! fibroblast growth factor production
relationship: positively_regulates GO:0090269 ! fibroblast growth factor production
created_by: tanyaberardini
creation_date: 2010-02-05T02:33:33Z

[Term]
id: GO:0090272
name: negative regulation of fibroblast growth factor production
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF]
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0090270 ! regulation of fibroblast growth factor production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0090269 ! fibroblast growth factor production
relationship: negatively_regulates GO:0090269 ! fibroblast growth factor production
created_by: tanyaberardini
creation_date: 2010-02-05T02:33:33Z

[Term]
id: GO:0090273
name: regulation of somatostatin secretion
namespace: biological_process
def: "Any process that modulates the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas." [GOC:BHF]
is_a: GO:0090276 ! regulation of peptide hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070253 ! somatostatin secretion
relationship: regulates GO:0070253 ! somatostatin secretion
created_by: tanyaberardini
creation_date: 2010-02-05T02:54:14Z

[Term]
id: GO:0090274
name: positive regulation of somatostatin secretion
namespace: biological_process
def: "Any process that increases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas." [GOC:BHF]
is_a: GO:0090273 ! regulation of somatostatin secretion
is_a: GO:0090277 ! positive regulation of peptide hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070253 ! somatostatin secretion
relationship: positively_regulates GO:0070253 ! somatostatin secretion
created_by: tanyaberardini
creation_date: 2010-02-05T02:54:14Z

[Term]
id: GO:0090275
name: negative regulation of somatostatin secretion
namespace: biological_process
def: "Any process that decreases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas." [GOC:BHF]
is_a: GO:0090273 ! regulation of somatostatin secretion
is_a: GO:0090278 ! negative regulation of peptide hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070253 ! somatostatin secretion
relationship: negatively_regulates GO:0070253 ! somatostatin secretion
created_by: tanyaberardini
creation_date: 2010-02-05T02:54:14Z

[Term]
id: GO:0090276
name: regulation of peptide hormone secretion
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules." [GOC:tb]
is_a: GO:0002791 ! regulation of peptide secretion
is_a: GO:0046883 ! regulation of hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030072 ! peptide hormone secretion
relationship: regulates GO:0030072 ! peptide hormone secretion
created_by: tanyaberardini
creation_date: 2010-02-05T02:56:39Z

[Term]
id: GO:0090277
name: positive regulation of peptide hormone secretion
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules." [GOC:tb]
is_a: GO:0002793 ! positive regulation of peptide secretion
is_a: GO:0046887 ! positive regulation of hormone secretion
is_a: GO:0090276 ! regulation of peptide hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030072 ! peptide hormone secretion
relationship: positively_regulates GO:0030072 ! peptide hormone secretion
created_by: tanyaberardini
creation_date: 2010-02-05T02:56:39Z

[Term]
id: GO:0090278
name: negative regulation of peptide hormone secretion
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules." [GOC:tb]
is_a: GO:0002792 ! negative regulation of peptide secretion
is_a: GO:0046888 ! negative regulation of hormone secretion
is_a: GO:0090276 ! regulation of peptide hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030072 ! peptide hormone secretion
relationship: negatively_regulates GO:0030072 ! peptide hormone secretion
created_by: tanyaberardini
creation_date: 2010-02-05T02:56:39Z

[Term]
id: GO:0090279
name: regulation of calcium ion import
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle." [GOC:BHF]
synonym: "regulation of transmembrane calcium influx" RELATED [GOC:tb]
is_a: GO:0034765 ! regulation of ion transmembrane transport
is_a: GO:0051924 ! regulation of calcium ion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070509 ! calcium ion import
relationship: regulates GO:0070509 ! calcium ion import
created_by: tanyaberardini
creation_date: 2010-02-08T05:11:20Z

[Term]
id: GO:0090280
name: positive regulation of calcium ion import
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle." [GOC:BHF]
synonym: "positive regulation of transmembrane calcium influx" RELATED [GOC:tb]
is_a: GO:0034767 ! positive regulation of ion transmembrane transport
is_a: GO:0051928 ! positive regulation of calcium ion transport
is_a: GO:0090279 ! regulation of calcium ion import
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070509 ! calcium ion import
relationship: positively_regulates GO:0070509 ! calcium ion import
created_by: tanyaberardini
creation_date: 2010-02-08T05:11:20Z

[Term]
id: GO:0090281
name: negative regulation of calcium ion import
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle." [GOC:BHF]
synonym: "negative regulation of transmembrane calcium influx" RELATED [GOC:tb]
is_a: GO:0034766 ! negative regulation of ion transmembrane transport
is_a: GO:0051926 ! negative regulation of calcium ion transport
is_a: GO:0090279 ! regulation of calcium ion import
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070509 ! calcium ion import
relationship: negatively_regulates GO:0070509 ! calcium ion import
created_by: tanyaberardini
creation_date: 2010-02-08T05:11:20Z

[Term]
id: GO:0090282
name: positive regulation of transcription involved in G2/M transition of mitotic cell cycle
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transcription of target genes that are transcribed as part of the G2/M transition of the mitotic cell cycle." [GOC:rn, PMID:10747051, PMID:10894548, PMID:10899128, PMID:10959837]
synonym: "activation of G2/M-specific transcription in the mitotic cell cycle" EXACT [GOC:rn]
synonym: "activation of transcription from RNA polymerase II promoter during G2/M-phase of the mitotic cell cycle" EXACT [GOC:rn]
synonym: "activation of transcription involved in G2/M transition of mitotic cell cycle" EXACT [GOC:rn]
synonym: "positive regulation of G2/M-specific transcription in the mitotic cell cycle" EXACT [GOC:rn]
synonym: "positive regulation of transcription from RNA polymerase II promoter during G2/M-phase of the mitotic cell cycle" EXACT [GOC:rn]
synonym: "up-regulation of G2/M-specific transcription in the mitotic cell cycle" EXACT [GOC:rn]
synonym: "up-regulation of transcription from RNA polymerase II promoter during G2/M transition of the mitotic cell cycle" EXACT [GOC:rn]
synonym: "up-regulation of transcription involved in G2/M transition of mitotic cell cycle" EXACT [GOC:rn]
is_a: GO:0000117 ! regulation of transcription involved in G2/M transition of mitotic cell cycle
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0045893 ! positive regulation of transcription, DNA-templated
intersection_of: part_of GO:0000086 ! G2/M transition of mitotic cell cycle
relationship: part_of GO:0000086 ! G2/M transition of mitotic cell cycle
created_by: tanyaberardini
creation_date: 2010-02-09T02:13:26Z

[Term]
id: GO:0090283
name: regulation of protein glycosylation in Golgi
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in any compartment of the Golgi apparatus." [GOC:pr, GOC:tb]
synonym: "regulation of protein amino acid glycosylation in Golgi" EXACT [GOC:bf]
is_a: GO:0060049 ! regulation of protein glycosylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0033578 ! protein glycosylation in Golgi
relationship: regulates GO:0033578 ! protein glycosylation in Golgi
created_by: tanyaberardini
creation_date: 2010-02-18T02:43:55Z

[Term]
id: GO:0090284
name: positive regulation of protein glycosylation in Golgi
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in any compartment of the Golgi apparatus." [GOC:pr, GOC:tb]
synonym: "positive regulation of protein amino acid glycosylation in Golgi" EXACT [GOC:bf]
is_a: GO:0060050 ! positive regulation of protein glycosylation
is_a: GO:0090283 ! regulation of protein glycosylation in Golgi
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0033578 ! protein glycosylation in Golgi
relationship: positively_regulates GO:0033578 ! protein glycosylation in Golgi
created_by: tanyaberardini
creation_date: 2010-02-18T02:43:55Z

[Term]
id: GO:0090285
name: negative regulation of protein glycosylation in Golgi
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in any compartment of the Golgi apparatus." [GOC:pr, GOC:tb]
synonym: "negative regulation of protein amino acid glycosylation in Golgi" EXACT [GOC:bf]
is_a: GO:0060051 ! negative regulation of protein glycosylation
is_a: GO:0090283 ! regulation of protein glycosylation in Golgi
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0033578 ! protein glycosylation in Golgi
relationship: negatively_regulates GO:0033578 ! protein glycosylation in Golgi
created_by: tanyaberardini
creation_date: 2010-02-18T02:43:55Z

[Term]
id: GO:0090286
name: cytoskeletal anchoring at nuclear membrane
namespace: biological_process
def: "The process in which cytoskeletal filaments are directly or indirectly linked to the nuclear membrane." [GOC:tb]
is_a: GO:0007010 ! cytoskeleton organization
is_a: GO:0032507 ! maintenance of protein location in cell
is_a: GO:1902589 ! single-organism organelle organization
created_by: tanyaberardini
creation_date: 2010-02-18T02:56:26Z

[Term]
id: GO:0090287
name: regulation of cellular response to growth factor stimulus
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:tb]
is_a: GO:0048583 ! regulation of response to stimulus
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071363 ! cellular response to growth factor stimulus
relationship: regulates GO:0071363 ! cellular response to growth factor stimulus
created_by: tanyaberardini
creation_date: 2010-02-18T03:01:25Z

[Term]
id: GO:0090288
name: negative regulation of cellular response to growth factor stimulus
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:BHF]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:0090287 ! regulation of cellular response to growth factor stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071363 ! cellular response to growth factor stimulus
relationship: negatively_regulates GO:0071363 ! cellular response to growth factor stimulus
created_by: tanyaberardini
creation_date: 2010-02-18T03:01:25Z

[Term]
id: GO:0090289
name: regulation of osteoclast proliferation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population." [GOC:tb]
is_a: GO:0070663 ! regulation of leukocyte proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002158 ! osteoclast proliferation
relationship: regulates GO:0002158 ! osteoclast proliferation
created_by: tanyaberardini
creation_date: 2010-02-18T03:11:03Z

[Term]
id: GO:0090290
name: positive regulation of osteoclast proliferation
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population." [GOC:tb]
is_a: GO:0070665 ! positive regulation of leukocyte proliferation
is_a: GO:0090289 ! regulation of osteoclast proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002158 ! osteoclast proliferation
relationship: positively_regulates GO:0002158 ! osteoclast proliferation
created_by: tanyaberardini
creation_date: 2010-02-18T03:11:03Z

[Term]
id: GO:0090291
name: negative regulation of osteoclast proliferation
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population." [GOC:tb]
is_a: GO:0070664 ! negative regulation of leukocyte proliferation
is_a: GO:0090289 ! regulation of osteoclast proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002158 ! osteoclast proliferation
relationship: negatively_regulates GO:0002158 ! osteoclast proliferation
created_by: tanyaberardini
creation_date: 2010-02-18T03:11:03Z

[Term]
id: GO:0090292
name: nuclear matrix anchoring at nuclear membrane
namespace: biological_process
def: "The process in which the nuclear matrix, the dense fibrillar network lying on the inner side of the nuclear membrane, is directly or indirectly linked to the nuclear membrane." [GOC:tb]
synonym: "nucleoskeleton anchoring at nuclear membrane" EXACT [GOC:tb]
is_a: GO:0043578 ! nuclear matrix organization
is_a: GO:0051457 ! maintenance of protein location in nucleus
is_a: GO:1902589 ! single-organism organelle organization
created_by: tanyaberardini
creation_date: 2010-02-22T03:05:13Z

[Term]
id: GO:0090293
name: nitrogen catabolite regulation of transcription
namespace: biological_process
def: "A transcription regulation process in which the presence of one nitrogen source leads to the modulation of the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other nitrogen sources." [GOC:mah, GOC:rb, PMID:19104072]
synonym: "regulation of transcription by nitrogen catabolites" EXACT [GOC:mah]
is_a: GO:0006355 ! regulation of transcription, DNA-templated
is_a: GO:0006808 ! regulation of nitrogen utilization
relationship: part_of GO:0031670 ! cellular response to nutrient
relationship: part_of GO:0071417 ! cellular response to organonitrogen compound
created_by: tanyaberardini
creation_date: 2010-02-24T02:31:53Z

[Term]
id: GO:0090294
name: nitrogen catabolite activation of transcription
namespace: biological_process
def: "A transcription regulation process in which the presence of one nitrogen source leads to an increase in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other nitrogen sources." [GOC:mah, GOC:rb, PMID:19104072]
synonym: "positive regulation of transcription by nitrogen catabolites" EXACT [GOC:mah]
is_a: GO:0045893 ! positive regulation of transcription, DNA-templated
is_a: GO:0090293 ! nitrogen catabolite regulation of transcription
created_by: tanyaberardini
creation_date: 2010-02-24T02:31:53Z

[Term]
id: GO:0090295
name: nitrogen catabolite repression of transcription
namespace: biological_process
def: "A transcription regulation process in which the presence of one nitrogen source leads to a decrease in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other nitrogen sources." [GOC:mah, GOC:rb, PMID:19104072]
synonym: "negative regulation of transcription by nitrogen catabolites" EXACT [GOC:mah]
synonym: "nitrogen catabolite repression" EXACT [GOC:mah, GOC:rb]
is_a: GO:0045892 ! negative regulation of transcription, DNA-templated
is_a: GO:0090293 ! nitrogen catabolite regulation of transcription
created_by: tanyaberardini
creation_date: 2010-02-24T02:31:53Z

[Term]
id: GO:0090296
name: regulation of mitochondrial DNA replication
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the process in which new strands of DNA are synthesized in the mitochondrion." [GOC:tb]
synonym: "regulation of mitochondrial DNA synthesis" RELATED [GOC:tb]
is_a: GO:0090329 ! regulation of DNA-dependent DNA replication
is_a: GO:1901858 ! regulation of mitochondrial DNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006264 ! mitochondrial DNA replication
relationship: regulates GO:0006264 ! mitochondrial DNA replication
created_by: tanyaberardini
creation_date: 2010-03-12T03:58:25Z

[Term]
id: GO:0090297
name: positive regulation of mitochondrial DNA replication
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the process in which new strands of DNA are synthesized in the mitochondrion." [GOC:tb]
synonym: "positive regulation of mitochondrial DNA synthesis" RELATED [GOC:tb]
is_a: GO:0090296 ! regulation of mitochondrial DNA replication
is_a: GO:1901860 ! positive regulation of mitochondrial DNA metabolic process
is_a: GO:2000105 ! positive regulation of DNA-dependent DNA replication
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006264 ! mitochondrial DNA replication
relationship: positively_regulates GO:0006264 ! mitochondrial DNA replication
created_by: tanyaberardini
creation_date: 2010-03-12T03:58:25Z

[Term]
id: GO:0090298
name: negative regulation of mitochondrial DNA replication
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the process in which new strands of DNA are synthesized in the mitochondrion." [GOC:tb]
synonym: "negative regulation of mitochondrial DNA synthesis" RELATED [GOC:tb]
is_a: GO:0090296 ! regulation of mitochondrial DNA replication
is_a: GO:1901859 ! negative regulation of mitochondrial DNA metabolic process
is_a: GO:2000104 ! negative regulation of DNA-dependent DNA replication
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006264 ! mitochondrial DNA replication
relationship: negatively_regulates GO:0006264 ! mitochondrial DNA replication
created_by: tanyaberardini
creation_date: 2010-03-12T03:58:25Z

[Term]
id: GO:0090299
name: regulation of neural crest formation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds." [GOC:tb]
is_a: GO:0010717 ! regulation of epithelial to mesenchymal transition
is_a: GO:0045995 ! regulation of embryonic development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0014029 ! neural crest formation
relationship: regulates GO:0014029 ! neural crest formation
created_by: tanyaberardini
creation_date: 2010-03-12T04:08:26Z

[Term]
id: GO:0090300
name: positive regulation of neural crest formation
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes." [GOC:tb]
is_a: GO:0010718 ! positive regulation of epithelial to mesenchymal transition
is_a: GO:0040019 ! positive regulation of embryonic development
is_a: GO:0090299 ! regulation of neural crest formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0014029 ! neural crest formation
relationship: positively_regulates GO:0014029 ! neural crest formation
created_by: tanyaberardini
creation_date: 2010-03-12T04:08:26Z

[Term]
id: GO:0090301
name: negative regulation of neural crest formation
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes." [GOC:tb]
is_a: GO:0010719 ! negative regulation of epithelial to mesenchymal transition
is_a: GO:0045992 ! negative regulation of embryonic development
is_a: GO:0090299 ! regulation of neural crest formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0014029 ! neural crest formation
relationship: negatively_regulates GO:0014029 ! neural crest formation
created_by: tanyaberardini
creation_date: 2010-03-12T04:08:26Z

[Term]
id: GO:0090302
name: APC-Cdc20 complex activity
namespace: molecular_function
def: "A ubiquitin-protein ligase activity that increases the rate or extent of the metaphase to anaphase transition of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb]
synonym: "mitotic anaphase-promoting complex activity" RELATED [GOC:vw]
synonym: "ubiquitin-protein ligase activity involved in positive regulation of mitotic metaphase/anaphase transition" EXACT [GOC:dph, GOC:mah, GOC:tb]
is_a: GO:0061630 ! ubiquitin protein ligase activity
intersection_of: GO:0061630 ! ubiquitin protein ligase activity
intersection_of: part_of GO:0045842 ! positive regulation of mitotic metaphase/anaphase transition
relationship: part_of GO:0045842 ! positive regulation of mitotic metaphase/anaphase transition
created_by: tanyaberardini
creation_date: 2010-03-17T10:27:04Z

[Term]
id: GO:0090303
name: positive regulation of wound healing
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." [GOC:BHF]
is_a: GO:0061041 ! regulation of wound healing
is_a: GO:1903036 ! positive regulation of response to wounding
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042060 ! wound healing
relationship: positively_regulates GO:0042060 ! wound healing
created_by: tanyaberardini
creation_date: 2010-03-22T02:12:03Z

[Term]
id: GO:0090304
name: nucleic acid metabolic process
namespace: biological_process
def: "Any cellular metabolic process involving nucleic acids." [GOC:dph, GOC:tb]
is_a: GO:0006139 ! nucleobase-containing compound metabolic process
is_a: GO:0043170 ! macromolecule metabolic process
created_by: tanyaberardini
creation_date: 2010-04-07T10:18:47Z

[Term]
id: GO:0090305
name: nucleic acid phosphodiester bond hydrolysis
namespace: biological_process
def: "The nucleic acid metabolic process in which the phosphodiester bonds between nucleotides are cleaved by hydrolysis." [GOC:dph, GOC:tb]
synonym: "nucleic acid cleavage" EXACT [GOC:dph, GOC:tb]
is_a: GO:0090304 ! nucleic acid metabolic process
created_by: tanyaberardini
creation_date: 2010-04-07T10:26:30Z

[Term]
id: GO:0090306
name: spindle assembly involved in meiosis
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the spindle that contributes to the process of meiosis." [GOC:tb, GOC:vw]
synonym: "meiotic spindle assembly" EXACT [GOC:vw]
is_a: GO:0000212 ! meiotic spindle organization
is_a: GO:0051225 ! spindle assembly
intersection_of: GO:0051225 ! spindle assembly
intersection_of: part_of GO:0007126 ! meiotic nuclear division
relationship: part_of GO:0007126 ! meiotic nuclear division
created_by: tanyaberardini
creation_date: 2010-04-09T11:21:56Z

[Term]
id: GO:0090307
name: mitotic spindle assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the spindle that contributes to the process of mitosis." [GOC:tb, GOC:vw]
synonym: "spindle assembly involved in mitosis" EXACT []
is_a: GO:0007052 ! mitotic spindle organization
is_a: GO:0051225 ! spindle assembly
is_a: GO:1902850 ! microtubule cytoskeleton organization involved in mitosis
intersection_of: GO:0051225 ! spindle assembly
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0007067 ! mitotic nuclear division
created_by: tanyaberardini
creation_date: 2010-04-09T11:31:28Z

[Term]
id: GO:0090308
name: regulation of methylation-dependent chromatin silencing
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the repression of transcription by methylation of DNA, leading to the formation of heterochromatin." [GOC:BHF]
is_a: GO:0031935 ! regulation of chromatin silencing
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006346 ! methylation-dependent chromatin silencing
relationship: regulates GO:0006346 ! methylation-dependent chromatin silencing
created_by: tanyaberardini
creation_date: 2010-04-09T02:12:53Z

[Term]
id: GO:0090309
name: positive regulation of methylation-dependent chromatin silencing
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the repression of transcription by methylation of DNA, leading to the formation of heterochromatin." [GOC:BHF]
is_a: GO:0031937 ! positive regulation of chromatin silencing
is_a: GO:0090308 ! regulation of methylation-dependent chromatin silencing
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006346 ! methylation-dependent chromatin silencing
relationship: positively_regulates GO:0006346 ! methylation-dependent chromatin silencing
created_by: tanyaberardini
creation_date: 2010-04-09T02:12:53Z

[Term]
id: GO:0090310
name: negative regulation of methylation-dependent chromatin silencing
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the repression of transcription by methylation of DNA, leading to the formation of heterochromatin." [GOC:BHF]
is_a: GO:0031936 ! negative regulation of chromatin silencing
is_a: GO:0090308 ! regulation of methylation-dependent chromatin silencing
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006346 ! methylation-dependent chromatin silencing
relationship: negatively_regulates GO:0006346 ! methylation-dependent chromatin silencing
created_by: tanyaberardini
creation_date: 2010-04-09T02:12:53Z

[Term]
id: GO:0090311
name: regulation of protein deacetylation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of protein deacetylation, the removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:tb]
synonym: "regulation of protein amino acid deacetylation" EXACT [GOC:bf]
is_a: GO:0031399 ! regulation of protein modification process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006476 ! protein deacetylation
relationship: regulates GO:0006476 ! protein deacetylation
created_by: tanyaberardini
creation_date: 2010-04-14T01:30:45Z

[Term]
id: GO:0090312
name: positive regulation of protein deacetylation
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of protein deacetylation, the removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ecd, PMID:20027304]
synonym: "positive regulation of protein amino acid deacetylation" EXACT [GOC:bf]
is_a: GO:0031401 ! positive regulation of protein modification process
is_a: GO:0090311 ! regulation of protein deacetylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006476 ! protein deacetylation
relationship: positively_regulates GO:0006476 ! protein deacetylation
created_by: tanyaberardini
creation_date: 2010-04-14T01:30:45Z

[Term]
id: GO:0090313
name: regulation of protein targeting to membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:tb]
is_a: GO:0051128 ! regulation of cellular component organization
is_a: GO:1903533 ! regulation of protein targeting
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006612 ! protein targeting to membrane
relationship: regulates GO:0006612 ! protein targeting to membrane
created_by: tanyaberardini
creation_date: 2010-04-16T03:42:22Z

[Term]
id: GO:0090314
name: positive regulation of protein targeting to membrane
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:tb]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:0090313 ! regulation of protein targeting to membrane
is_a: GO:0090316 ! positive regulation of intracellular protein transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006612 ! protein targeting to membrane
relationship: positively_regulates GO:0006612 ! protein targeting to membrane
created_by: tanyaberardini
creation_date: 2010-04-16T03:42:22Z

[Term]
id: GO:0090315
name: negative regulation of protein targeting to membrane
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:tb]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:0090313 ! regulation of protein targeting to membrane
is_a: GO:0090317 ! negative regulation of intracellular protein transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006612 ! protein targeting to membrane
relationship: negatively_regulates GO:0006612 ! protein targeting to membrane
created_by: tanyaberardini
creation_date: 2010-04-16T03:42:22Z

[Term]
id: GO:0090316
name: positive regulation of intracellular protein transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells." [GOC:tb]
is_a: GO:0032388 ! positive regulation of intracellular transport
is_a: GO:0033157 ! regulation of intracellular protein transport
is_a: GO:0051222 ! positive regulation of protein transport
is_a: GO:1903829 ! positive regulation of cellular protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006886 ! intracellular protein transport
relationship: positively_regulates GO:0006886 ! intracellular protein transport
created_by: tanyaberardini
creation_date: 2010-04-16T03:45:07Z

[Term]
id: GO:0090317
name: negative regulation of intracellular protein transport
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells." [GOC:tb]
is_a: GO:0032387 ! negative regulation of intracellular transport
is_a: GO:0033157 ! regulation of intracellular protein transport
is_a: GO:0051224 ! negative regulation of protein transport
is_a: GO:1903828 ! negative regulation of cellular protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006886 ! intracellular protein transport
relationship: negatively_regulates GO:0006886 ! intracellular protein transport
created_by: tanyaberardini
creation_date: 2010-04-16T03:45:07Z

[Term]
id: GO:0090318
name: regulation of chylomicron remodeling
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of chylomicron remodeling. Chylomicron remodeling is the acquisition, loss or modification of a protein or lipid within a chylomicron, including the hydrolysis of triglyceride by lipoprotein lipase and the subsequent loss of free fatty acid." [GOC:tb]
is_a: GO:0051128 ! regulation of cellular component organization
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034371 ! chylomicron remodeling
relationship: regulates GO:0034371 ! chylomicron remodeling
created_by: tanyaberardini
creation_date: 2010-04-30T10:09:08Z

[Term]
id: GO:0090319
name: positive regulation of chylomicron remodeling
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of chylomicron remodeling. Chylomicron remodeling is the acquisition, loss or modification of a protein or lipid within a chylomicron, including the hydrolysis of triglyceride by lipoprotein lipase and the subsequent loss of free fatty acid." [GOC:BHF]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0090318 ! regulation of chylomicron remodeling
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034371 ! chylomicron remodeling
relationship: positively_regulates GO:0034371 ! chylomicron remodeling
created_by: tanyaberardini
creation_date: 2010-04-30T10:09:08Z

[Term]
id: GO:0090320
name: regulation of chylomicron remnant clearance
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of chylomicron remnant clearance. Chylomicron clearance is the process in which a chylomicron remnant is removed from the blood via receptor-mediated endocytosis into liver cells and its constituent parts degraded." [GOC:tb]
is_a: GO:0010984 ! regulation of lipoprotein particle clearance
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034382 ! chylomicron remnant clearance
relationship: regulates GO:0034382 ! chylomicron remnant clearance
created_by: tanyaberardini
creation_date: 2010-04-30T10:20:26Z

[Term]
id: GO:0090321
name: positive regulation of chylomicron remnant clearance
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of chylomicron remnant clearance. Chylomicron clearance is the process in which a chylomicron remnant is removed from the blood via receptor-mediated endocytosis into liver cells and its constituent parts degraded." [GOC:BHF]
is_a: GO:0010986 ! positive regulation of lipoprotein particle clearance
is_a: GO:0090320 ! regulation of chylomicron remnant clearance
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034382 ! chylomicron remnant clearance
relationship: positively_regulates GO:0034382 ! chylomicron remnant clearance
created_by: tanyaberardini
creation_date: 2010-04-30T10:20:26Z

[Term]
id: GO:0090322
name: regulation of superoxide metabolic process
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of superoxide metabolism, the chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species." [GOC:tb]
synonym: "regulation of superoxide metabolism" EXACT [GOC:tb]
is_a: GO:2000377 ! regulation of reactive oxygen species metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006801 ! superoxide metabolic process
relationship: regulates GO:0006801 ! superoxide metabolic process
created_by: tanyaberardini
creation_date: 2010-05-06T02:29:05Z

[Term]
id: GO:0090323
name: prostaglandin secretion involved in immune response
namespace: biological_process
def: "The regulated release of a prostaglandin that contributes to the immune response. Prostaglandins are a group of biologically active metabolites which contain a cyclopentane ring." [GOC:dph, GOC:tb]
is_a: GO:0002440 ! production of molecular mediator of immune response
is_a: GO:0032310 ! prostaglandin secretion
intersection_of: GO:0032310 ! prostaglandin secretion
intersection_of: part_of GO:0006955 ! immune response
relationship: part_of GO:0006955 ! immune response
created_by: tanyaberardini
creation_date: 2010-05-12T10:41:04Z

[Term]
id: GO:0090324
name: negative regulation of oxidative phosphorylation
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis." [GOC:BHF]
is_a: GO:0002082 ! regulation of oxidative phosphorylation
is_a: GO:0042326 ! negative regulation of phosphorylation
is_a: GO:1903579 ! negative regulation of ATP metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006119 ! oxidative phosphorylation
relationship: negatively_regulates GO:0006119 ! oxidative phosphorylation
created_by: tanyaberardini
creation_date: 2010-05-14T10:21:33Z

[Term]
id: GO:0090325
name: regulation of locomotion involved in locomotory behavior
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:dph, GOC:kmv, GOC:tb]
is_a: GO:0040012 ! regulation of locomotion
is_a: GO:0050795 ! regulation of behavior
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031987 ! locomotion involved in locomotory behavior
relationship: regulates GO:0031987 ! locomotion involved in locomotory behavior
created_by: tanyaberardini
creation_date: 2010-05-14T10:24:29Z

[Term]
id: GO:0090326
name: positive regulation of locomotion involved in locomotory behavior
namespace: biological_process
def: "Any process that increases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:dph, GOC:kmv, GOC:tb]
is_a: GO:0040017 ! positive regulation of locomotion
is_a: GO:0048520 ! positive regulation of behavior
is_a: GO:0090325 ! regulation of locomotion involved in locomotory behavior
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: positively_regulates GO:0031987 ! locomotion involved in locomotory behavior
relationship: positively_regulates GO:0031987 ! locomotion involved in locomotory behavior
created_by: tanyaberardini
creation_date: 2010-05-14T10:26:58Z

[Term]
id: GO:0090327
name: negative regulation of locomotion involved in locomotory behavior
namespace: biological_process
def: "Any process that decreases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:dph, GOC:kmv, GOC:tb]
is_a: GO:0040013 ! negative regulation of locomotion
is_a: GO:0048521 ! negative regulation of behavior
is_a: GO:0090325 ! regulation of locomotion involved in locomotory behavior
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0031987 ! locomotion involved in locomotory behavior
relationship: negatively_regulates GO:0031987 ! locomotion involved in locomotory behavior
created_by: tanyaberardini
creation_date: 2010-05-14T10:26:58Z

[Term]
id: GO:0090328
name: regulation of olfactory learning
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of olfactory learning. Olfactory learning is any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [GOC:dph, GOC:tb]
is_a: GO:0031644 ! regulation of neurological system process
is_a: GO:0050795 ! regulation of behavior
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008355 ! olfactory learning
relationship: regulates GO:0008355 ! olfactory learning
created_by: tanyaberardini
creation_date: 2010-05-14T10:37:22Z

[Term]
id: GO:0090329
name: regulation of DNA-dependent DNA replication
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of DNA-dependent DNA replication, the process in which new strands of DNA are synthesized, using parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:dph, GOC:tb]
is_a: GO:0006275 ! regulation of DNA replication
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006261 ! DNA-dependent DNA replication
relationship: regulates GO:0006261 ! DNA-dependent DNA replication
created_by: tanyaberardini
creation_date: 2010-05-14T10:42:04Z

[Term]
id: GO:0090330
name: regulation of platelet aggregation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules." [GOC:dph, GOC:tb]
is_a: GO:0010543 ! regulation of platelet activation
is_a: GO:0034110 ! regulation of homotypic cell-cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070527 ! platelet aggregation
relationship: regulates GO:0070527 ! platelet aggregation
created_by: tanyaberardini
creation_date: 2010-05-14T10:46:08Z

[Term]
id: GO:0090331
name: negative regulation of platelet aggregation
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules." [GOC:BHF]
synonym: "platelet disaggregation" NARROW [GOC:dph, PMID:12871378]
is_a: GO:0010544 ! negative regulation of platelet activation
is_a: GO:0034111 ! negative regulation of homotypic cell-cell adhesion
is_a: GO:0090330 ! regulation of platelet aggregation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070527 ! platelet aggregation
relationship: negatively_regulates GO:0070527 ! platelet aggregation
created_by: tanyaberardini
creation_date: 2010-05-14T10:46:08Z

[Term]
id: GO:0090332
name: stomatal closure
namespace: biological_process
def: "The process of closing of stomata, pores in the epidermis of leaves and stems bordered by two guard cells and serving in gas exchange." [GOC:tb]
is_a: GO:0010118 ! stomatal movement
created_by: tanyaberardini
creation_date: 2010-05-26T02:14:49Z

[Term]
id: GO:0090333
name: regulation of stomatal closure
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of stomatal closure. Stomatal closure is the process of closing of stomata, pores in the epidermis of leaves and stems bordered by two guard cells and serving in gas exchange." [GOC:tb]
is_a: GO:0010119 ! regulation of stomatal movement
relationship: regulates GO:0090332 ! stomatal closure
created_by: tanyaberardini
creation_date: 2010-05-26T02:14:49Z

[Term]
id: GO:0090334
name: regulation of cell wall (1->3)-beta-D-glucan biosynthetic process
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in the walls of cells." [GOC:tb]
synonym: "regulation of cell wall 1,3-beta-D-glucan biosynthetic process" BROAD []
synonym: "regulation of cell wall 1,3-beta-glucan biosynthetic process" BROAD []
is_a: GO:0010981 ! regulation of cell wall macromolecule metabolic process
is_a: GO:0032953 ! regulation of (1->3)-beta-D-glucan biosynthetic process
is_a: GO:0032995 ! regulation of fungal-type cell wall biogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034411 ! cell wall (1->3)-beta-D-glucan biosynthetic process
relationship: regulates GO:0034411 ! cell wall (1->3)-beta-D-glucan biosynthetic process
created_by: tanyaberardini
creation_date: 2010-06-01T03:11:34Z

[Term]
id: GO:0090335
name: regulation of brown fat cell differentiation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of brown fat cell differentiation. Brown fat cell differentiation is the process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria." [GOC:tb]
is_a: GO:0045598 ! regulation of fat cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050873 ! brown fat cell differentiation
relationship: regulates GO:0050873 ! brown fat cell differentiation
created_by: tanyaberardini
creation_date: 2010-06-01T03:16:57Z

[Term]
id: GO:0090336
name: positive regulation of brown fat cell differentiation
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of brown fat cell differentiation. Brown fat cell differentiation is the process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria." [GOC:BHF]
is_a: GO:0045600 ! positive regulation of fat cell differentiation
is_a: GO:0090335 ! regulation of brown fat cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0050873 ! brown fat cell differentiation
relationship: positively_regulates GO:0050873 ! brown fat cell differentiation
created_by: tanyaberardini
creation_date: 2010-06-01T03:19:26Z

[Term]
id: GO:0090337
name: regulation of formin-nucleated actin cable assembly
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of formin-nucleated actin cable assembly. Formin-nucleated actin cable assembly is the aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins." [GOC:jh, GOC:tb, PMID:12810699, PMID:15923184]
is_a: GO:0032231 ! regulation of actin filament bundle assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070649 ! formin-nucleated actin cable assembly
relationship: regulates GO:0070649 ! formin-nucleated actin cable assembly
created_by: tanyaberardini
creation_date: 2010-06-01T03:26:31Z

[Term]
id: GO:0090338
name: positive regulation of formin-nucleated actin cable assembly
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of formin-nucleated actin cable assembly. Formin-nucleated actin cable assembly is the aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins." [GOC:jh, GOC:tb, PMID:12810699, PMID:15923184]
is_a: GO:0032233 ! positive regulation of actin filament bundle assembly
is_a: GO:0090337 ! regulation of formin-nucleated actin cable assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070649 ! formin-nucleated actin cable assembly
relationship: positively_regulates GO:0070649 ! formin-nucleated actin cable assembly
created_by: tanyaberardini
creation_date: 2010-06-01T03:26:31Z

[Term]
id: GO:0090339
name: negative regulation of formin-nucleated actin cable assembly
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of formin-nucleated actin cable assembly. Formin-nucleated actin cable assembly is the aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins." [GOC:jh, GOC:tb, PMID:12810699, PMID:15923184]
is_a: GO:0032232 ! negative regulation of actin filament bundle assembly
is_a: GO:0090337 ! regulation of formin-nucleated actin cable assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070649 ! formin-nucleated actin cable assembly
relationship: negatively_regulates GO:0070649 ! formin-nucleated actin cable assembly
created_by: tanyaberardini
creation_date: 2010-06-01T03:26:31Z

[Term]
id: GO:0090340
name: positive regulation of secretion of lysosomal enzymes
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of secretion of lysosomal enzymes, the controlled release of lysosomal enzymes by a cell." [GOC:BHF]
is_a: GO:0050714 ! positive regulation of protein secretion
is_a: GO:0090182 ! regulation of secretion of lysosomal enzymes
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0033299 ! secretion of lysosomal enzymes
relationship: positively_regulates GO:0033299 ! secretion of lysosomal enzymes
created_by: tanyaberardini
creation_date: 2010-06-01T03:35:57Z

[Term]
id: GO:0090341
name: negative regulation of secretion of lysosomal enzymes
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of secretion of lysosomal enzymes, the controlled release of lysosomal enzymes by a cell." [GOC:BHF]
is_a: GO:0050709 ! negative regulation of protein secretion
is_a: GO:0090182 ! regulation of secretion of lysosomal enzymes
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0033299 ! secretion of lysosomal enzymes
relationship: negatively_regulates GO:0033299 ! secretion of lysosomal enzymes
created_by: tanyaberardini
creation_date: 2010-06-01T03:35:57Z

[Term]
id: GO:0090342
name: regulation of cell aging
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of cell aging. Cell aging is the progression of the cell from its inception to the end of its lifespan." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007569 ! cell aging
relationship: regulates GO:0007569 ! cell aging
created_by: tanyaberardini
creation_date: 2010-06-02T10:12:37Z

[Term]
id: GO:0090343
name: positive regulation of cell aging
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of cell aging. Cell aging is the progression of the cell from its inception to the end of its lifespan." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0090342 ! regulation of cell aging
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007569 ! cell aging
relationship: positively_regulates GO:0007569 ! cell aging
created_by: tanyaberardini
creation_date: 2010-06-02T10:12:37Z

[Term]
id: GO:0090344
name: negative regulation of cell aging
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of cell aging. Cell aging is the progression of the cell from its inception to the end of its lifespan." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0090342 ! regulation of cell aging
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007569 ! cell aging
relationship: negatively_regulates GO:0007569 ! cell aging
created_by: tanyaberardini
creation_date: 2010-06-02T10:12:37Z

[Term]
id: GO:0090345
name: cellular organohalogen metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving organohalogen compounds, as carried out by individual cells." [GOC:BHF]
is_a: GO:0044237 ! cellular metabolic process
created_by: tanyaberardini
creation_date: 2010-06-02T10:36:42Z

[Term]
id: GO:0090346
name: cellular organofluorine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving organofluorine compounds, as carried out by individual cells." [GOC:BHF]
is_a: GO:0090345 ! cellular organohalogen metabolic process
created_by: tanyaberardini
creation_date: 2010-06-02T10:36:42Z

[Term]
id: GO:0090347
name: regulation of cellular organohalogen metabolic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways involving organohalogen compounds, as carried out by individual cells." [GOC:BHF]
is_a: GO:0031323 ! regulation of cellular metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0090345 ! cellular organohalogen metabolic process
relationship: regulates GO:0090345 ! cellular organohalogen metabolic process
created_by: tanyaberardini
creation_date: 2010-06-02T10:36:42Z

[Term]
id: GO:0090348
name: regulation of cellular organofluorine metabolic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways involving organofluorine compounds, as carried out by individual cells." [GOC:BHF]
is_a: GO:0090347 ! regulation of cellular organohalogen metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0090346 ! cellular organofluorine metabolic process
relationship: regulates GO:0090346 ! cellular organofluorine metabolic process
created_by: tanyaberardini
creation_date: 2010-06-02T10:36:42Z

[Term]
id: GO:0090349
name: negative regulation of cellular organohalogen metabolic process
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways involving organohalogen compounds, as carried out by individual cells." [GOC:BHF]
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0090347 ! regulation of cellular organohalogen metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0090345 ! cellular organohalogen metabolic process
relationship: negatively_regulates GO:0090345 ! cellular organohalogen metabolic process
created_by: tanyaberardini
creation_date: 2010-06-02T10:36:42Z

[Term]
id: GO:0090350
name: negative regulation of cellular organofluorine metabolic process
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways involving organofluorine compounds, as carried out by individual cells." [GOC:BHF]
is_a: GO:0090348 ! regulation of cellular organofluorine metabolic process
is_a: GO:0090349 ! negative regulation of cellular organohalogen metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0090346 ! cellular organofluorine metabolic process
relationship: negatively_regulates GO:0090346 ! cellular organofluorine metabolic process
created_by: tanyaberardini
creation_date: 2010-06-02T10:36:42Z

[Term]
id: GO:0090351
name: seedling development
namespace: biological_process
def: "The process whose specific outcome is the progression of the seedling over time, beginning with seed germination and ending when the first adult leaves emerge." [GOC:tb, PO:0007131]
xref: PO:0008037
is_a: GO:0009791 ! post-embryonic development
created_by: tanyaberardini
creation_date: 2010-06-10T03:33:10Z

[Term]
id: GO:0090352
name: regulation of nitrate assimilation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the uptake, from the environment, of nitrates, inorganic or organic salts and esters of nitric acid and the subsequent reduction of nitrate ion to other, less highly oxidized, inorganic nitrogenous substances." [GOC:tb]
is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:1903314 ! regulation of nitrogen cycle metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042128 ! nitrate assimilation
relationship: regulates GO:0042128 ! nitrate assimilation
created_by: tanyaberardini
creation_date: 2010-06-10T04:11:13Z

[Term]
id: GO:0090353
name: polygalacturonase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a polygalacturonase. Polygalacturonases catalyze the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans." [GOC:tb]
is_a: GO:0004857 ! enzyme inhibitor activity
created_by: tanyaberardini
creation_date: 2010-06-15T04:19:49Z

[Term]
id: GO:0090354
name: regulation of auxin metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving auxins, plant hormones that regulate aspects of plant growth." [GOC:tb]
synonym: "regulation of auxin metabolism" EXACT [GOC:tb]
is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:0032350 ! regulation of hormone metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009850 ! auxin metabolic process
relationship: regulates GO:0009850 ! auxin metabolic process
created_by: tanyaberardini
creation_date: 2010-06-29T01:51:18Z

[Term]
id: GO:0090355
name: positive regulation of auxin metabolic process
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving auxins, plant hormones that regulate aspects of plant growth." [GOC:tb]
synonym: "positive regulation of auxin metabolism" EXACT [GOC:tb]
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0032352 ! positive regulation of hormone metabolic process
is_a: GO:0090354 ! regulation of auxin metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009850 ! auxin metabolic process
relationship: positively_regulates GO:0009850 ! auxin metabolic process
created_by: tanyaberardini
creation_date: 2010-06-29T01:51:18Z

[Term]
id: GO:0090356
name: negative regulation of auxin metabolic process
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving auxins, plant hormones that regulate aspects of plant growth." [GOC:tb]
synonym: "negative regulation of auxin metabolism" EXACT [GOC:tb]
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0032351 ! negative regulation of hormone metabolic process
is_a: GO:0090354 ! regulation of auxin metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009850 ! auxin metabolic process
relationship: negatively_regulates GO:0009850 ! auxin metabolic process
created_by: tanyaberardini
creation_date: 2010-06-29T01:51:18Z

[Term]
id: GO:0090357
name: regulation of tryptophan metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid." [GOC:tb]
synonym: "regulation of tryptophan metabolism" EXACT [GOC:tb]
is_a: GO:0006521 ! regulation of cellular amino acid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006568 ! tryptophan metabolic process
relationship: regulates GO:0006568 ! tryptophan metabolic process
created_by: tanyaberardini
creation_date: 2010-06-29T02:38:48Z

[Term]
id: GO:0090358
name: positive regulation of tryptophan metabolic process
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid." [GOC:tb]
synonym: "positive regulation of tryptophan metabolism" EXACT [GOC:tb]
is_a: GO:0045764 ! positive regulation of cellular amino acid metabolic process
is_a: GO:0090357 ! regulation of tryptophan metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006568 ! tryptophan metabolic process
relationship: positively_regulates GO:0006568 ! tryptophan metabolic process
created_by: tanyaberardini
creation_date: 2010-06-29T02:38:48Z

[Term]
id: GO:0090359
name: negative regulation of abscisic acid biosynthetic process
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of abscisic acid." [GOC:tb]
synonym: "negative regulation of abscisic acid biosynthesis" EXACT [GOC:tb]
is_a: GO:0010115 ! regulation of abscisic acid biosynthetic process
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0045827 ! negative regulation of isoprenoid metabolic process
is_a: GO:0051055 ! negative regulation of lipid biosynthetic process
is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009688 ! abscisic acid biosynthetic process
relationship: negatively_regulates GO:0009688 ! abscisic acid biosynthetic process
created_by: tanyaberardini
creation_date: 2010-06-29T02:47:12Z

[Term]
id: GO:0090360
name: platelet-derived growth factor production
namespace: biological_process
def: "The appearance of any platelet-derived growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF]
is_a: GO:0001816 ! cytokine production
created_by: tanyaberardini
creation_date: 2010-07-12T10:32:27Z

[Term]
id: GO:0090361
name: regulation of platelet-derived growth factor production
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the appearance of any platelet-derived growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF]
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0090360 ! platelet-derived growth factor production
relationship: regulates GO:0090360 ! platelet-derived growth factor production
created_by: tanyaberardini
creation_date: 2010-07-12T10:32:27Z

[Term]
id: GO:0090362
name: positive regulation of platelet-derived growth factor production
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the appearance of any platelet-derived growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF]
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0090361 ! regulation of platelet-derived growth factor production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0090360 ! platelet-derived growth factor production
relationship: positively_regulates GO:0090360 ! platelet-derived growth factor production
created_by: tanyaberardini
creation_date: 2010-07-12T10:32:27Z

[Term]
id: GO:0090363
name: regulation of proteasome core complex assembly
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the aggregation, arrangement and bonding together of a mature, active 20S proteasome core particle complex that does not contain any regulatory particles." [GOC:dph, GOC:elh, GOC:tb]
is_a: GO:0090364 ! regulation of proteasome assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0080129 ! proteasome core complex assembly
relationship: regulates GO:0080129 ! proteasome core complex assembly
created_by: tanyaberardini
creation_date: 2010-07-12T10:48:57Z

[Term]
id: GO:0090364
name: regulation of proteasome assembly
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the aggregation, arrangement and bonding together of a mature, active proteasome complex." [GOC:dph, GOC:elh, GOC:tb]
is_a: GO:0043254 ! regulation of protein complex assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043248 ! proteasome assembly
relationship: regulates GO:0043248 ! proteasome assembly
created_by: tanyaberardini
creation_date: 2010-07-12T10:55:21Z

[Term]
id: GO:0090365
name: regulation of mRNA modification
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically." [GOC:dph, GOC:sl, GOC:tb, PMID:14559896]
synonym: "regulation of mRNA editing" NARROW []
is_a: GO:1903311 ! regulation of mRNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016556 ! mRNA modification
relationship: regulates GO:0016556 ! mRNA modification
created_by: tanyaberardini
creation_date: 2010-07-12T11:04:45Z

[Term]
id: GO:0090366
name: positive regulation of mRNA modification
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically." [GOC:dph, GOC:sl, GOC:tb]
is_a: GO:0090365 ! regulation of mRNA modification
is_a: GO:1903313 ! positive regulation of mRNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016556 ! mRNA modification
relationship: positively_regulates GO:0016556 ! mRNA modification
created_by: tanyaberardini
creation_date: 2010-07-12T11:04:45Z

[Term]
id: GO:0090367
name: negative regulation of mRNA modification
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically." [GOC:dph, GOC:sl, GOC:tb]
is_a: GO:0090365 ! regulation of mRNA modification
is_a: GO:1903312 ! negative regulation of mRNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016556 ! mRNA modification
relationship: negatively_regulates GO:0016556 ! mRNA modification
created_by: tanyaberardini
creation_date: 2010-07-12T11:04:45Z

[Term]
id: GO:0090368
name: regulation of ornithine metabolic process
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways involving ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis." [GOC:dph, GOC:jp, GOC:tb]
is_a: GO:0006521 ! regulation of cellular amino acid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006591 ! ornithine metabolic process
relationship: regulates GO:0006591 ! ornithine metabolic process
created_by: tanyaberardini
creation_date: 2010-07-12T11:14:12Z

[Term]
id: GO:0090369
name: ornithine carbamoyltransferase inhibitor activity
namespace: molecular_function
def: "Stops, prevents, or reduces ornithine carbamoyltransferase activity, the catalysis of the reaction: carbamoyl phosphate + L-ornithine = phosphate + L-citrulline." [GOC:dph, GOC:jp, GOC:tb]
is_a: GO:0004857 ! enzyme inhibitor activity
relationship: negatively_regulates GO:0004585 ! ornithine carbamoyltransferase activity
relationship: part_of GO:0090368 ! regulation of ornithine metabolic process
created_by: tanyaberardini
creation_date: 2010-07-12T11:19:55Z

[Term]
id: GO:0090370
name: negative regulation of cholesterol efflux
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle." [GOC:dph, GOC:tb, GOC:yaf]
is_a: GO:0010874 ! regulation of cholesterol efflux
is_a: GO:0032375 ! negative regulation of cholesterol transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0033344 ! cholesterol efflux
relationship: negatively_regulates GO:0033344 ! cholesterol efflux
created_by: tanyaberardini
creation_date: 2010-07-12T11:26:04Z

[Term]
id: GO:0090371
name: regulation of glycerol transport
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the directed movement of glycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:jh, GOC:tb]
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0015793 ! glycerol transport
relationship: regulates GO:0015793 ! glycerol transport
created_by: tanyaberardini
creation_date: 2010-07-12T11:30:22Z

[Term]
id: GO:0090372
name: positive regulation of glycerol transport
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the directed movement of glycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:jh, GOC:tb]
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:0090371 ! regulation of glycerol transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0015793 ! glycerol transport
relationship: positively_regulates GO:0015793 ! glycerol transport
created_by: tanyaberardini
creation_date: 2010-07-12T11:30:22Z

[Term]
id: GO:0090373
name: negative regulation of glycerol transport
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the directed movement of glycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:jh, GOC:tb]
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:0090371 ! regulation of glycerol transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0015793 ! glycerol transport
relationship: negatively_regulates GO:0015793 ! glycerol transport
created_by: tanyaberardini
creation_date: 2010-07-12T11:30:22Z

[Term]
id: GO:0090374
name: oligopeptide export from mitochondrion
namespace: biological_process
def: "The directed movement of oligopeptides out of mitochondria into the cytosol by means of some agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [PMID:11251115]
is_a: GO:0035672 ! oligopeptide transmembrane transport
is_a: GO:1990542 ! mitochondrial transmembrane transport
relationship: occurs_in GO:0005737 ! cytoplasm
created_by: tanyaberardini
creation_date: 2010-08-27T04:38:18Z

[Term]
id: GO:0090375
name: negative regulation of transcription from RNA polymerase II promoter in response to iron ion starvation
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of iron ions." [GOC:tb]
synonym: "negative regulation of transcription from RNA polymerase II promoter in response to iron deficiency" EXACT [GOC:tb]
is_a: GO:0033217 ! regulation of transcription from RNA polymerase II promoter in response to iron ion starvation
is_a: GO:0097201 ! negative regulation of transcription from RNA polymerase II promoter in response to stress
created_by: tanyaberardini
creation_date: 2010-09-01T01:22:23Z

[Term]
id: GO:0090376
name: seed trichome differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized epidermal cell acquires the specialized features of a seed trichome. A seed trichome is a trichome that develops from seed coat epidermis and is often long with putative dispersal function." [GOC:tb, PMID:17905721]
synonym: "cotton fiber development" NARROW [GOC:tb]
synonym: "seed hair differentiation" EXACT [PO:0004511]
synonym: "seed trichome development" RELATED [GOC:tb]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0010026 ! trichome differentiation
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
relationship: part_of GO:0048316 ! seed development
created_by: tanyaberardini
creation_date: 2010-09-15T02:07:10Z

[Term]
id: GO:0090377
name: seed trichome initiation
namespace: biological_process
def: "The process in which the developmental fate of an epidermal cell becomes restricted such that it will develop into a seed trichome, causing a change in the orientation of cell division in the ovule epidermis at or just before anthesis." [PMID:17905721]
comment: These processes continue up to 3 days post-anthesis (DPA) in Gossypium spp.
synonym: "seed trichome fate commitment" EXACT [GOC:tb]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0090376 ! seed trichome differentiation
created_by: tanyaberardini
creation_date: 2010-09-15T02:13:59Z

[Term]
id: GO:0090378
name: seed trichome elongation
namespace: biological_process
def: "The process in which a seed trichome irreversibly increases in size in one [spatial] dimension or along one axis, resulting in the morphogenesis of the cell." [GOC:tb]
comment: The increase in length of the seed trichome without cell division. Elongation is defined to be from 5 to 20 DPA in Gossypium spp.
is_a: GO:0000904 ! cell morphogenesis involved in differentiation
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0009826 ! unidimensional cell growth
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
relationship: part_of GO:0090376 ! seed trichome differentiation
created_by: tanyaberardini
creation_date: 2010-09-15T02:20:47Z

[Term]
id: GO:0090379
name: secondary cell wall biogenesis involved in seed trichome differentiation
namespace: biological_process
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of inextensible cellulose- and pectin-containing cell walls that are formed between the plasma membrane and primary cell wall of seed trichomes after cell expansion is complete." [GOC:tb]
comment: The processes involved in the massive amount of secondary wall cellulose synthesis in seed trichomes continue to 30 DPA in Gossypium spp.
synonym: "secondary cell wall biosynthesis involved in seed trichome differentiation" EXACT [GOC:tb]
synonym: "seed trichome secondary wall biosynthesis" RELATED [GOC:tb]
is_a: GO:0009834 ! plant-type secondary cell wall biogenesis
is_a: GO:0022402 ! cell cycle process
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
intersection_of: GO:0009834 ! plant-type secondary cell wall biogenesis
intersection_of: part_of GO:0090376 ! seed trichome differentiation
relationship: part_of GO:0090376 ! seed trichome differentiation
created_by: tanyaberardini
creation_date: 2010-09-15T02:24:34Z

[Term]
id: GO:0090380
name: seed trichome maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a seed trichome to attain its fully functional state." [GOC:tb]
comment: These processes continue to 60 DPA in Gossypium spp.
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0048469 ! cell maturation
relationship: part_of GO:0090376 ! seed trichome differentiation
created_by: tanyaberardini
creation_date: 2010-09-15T02:29:42Z

[Term]
id: GO:0090381
name: regulation of heart induction
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of heart induction. Heart induction is the close range interaction between mesoderm and endoderm or ectoderm that causes cells to change their fates and specify the development of the heart." [GOC:dph, GOC:tb]
is_a: GO:0003156 ! regulation of organ formation
is_a: GO:0010453 ! regulation of cell fate commitment
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0023051 ! regulation of signaling
is_a: GO:2000826 ! regulation of heart morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003129 ! heart induction
relationship: regulates GO:0003129 ! heart induction
created_by: tanyaberardini
creation_date: 2010-10-04T10:23:43Z

[Term]
id: GO:0090382
name: phagosome maturation
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the arrangement of constituent parts of a phagosome within a cell. Phagosome maturation begins with endocytosis and formation of the early phagosome and ends with the formation of the hybrid organelle, the phagolysosome." [GOC:kmv, GOC:tb]
is_a: GO:0006996 ! organelle organization
created_by: tanyaberardini
creation_date: 2010-10-19T11:10:34Z

[Term]
id: GO:0090383
name: phagosome acidification
namespace: biological_process
def: "Any process that reduces the pH of the phagosome, measured by the concentration of the hydrogen ion." [GOC:kmv, GOC:tb]
synonym: "phagosomal acidification" EXACT [GOC:kmv, GOC:tb]
is_a: GO:0051452 ! intracellular pH reduction
relationship: part_of GO:0090382 ! phagosome maturation
created_by: tanyaberardini
creation_date: 2010-10-27T10:20:22Z

[Term]
id: GO:0090384
name: phagosome-lysosome docking
namespace: biological_process
def: "The initial attachment of a phagosome membrane to a lysosome membrane. Docking requires only that the proteins come close enough to interact and adhere." [GOC:kmv, GOC:tb]
synonym: "lysosome recruitment to phagosome" EXACT [GOC:kmv, GOC:tb]
is_a: GO:0048278 ! vesicle docking
relationship: part_of GO:0001845 ! phagolysosome assembly
created_by: tanyaberardini
creation_date: 2010-10-27T10:24:28Z

[Term]
id: GO:0090385
name: phagosome-lysosome fusion
namespace: biological_process
def: "The creation of a phagolysosome from a phagosome and a lysosome." [GOC:kmv, GOC:tb]
is_a: GO:0006906 ! vesicle fusion
relationship: part_of GO:0001845 ! phagolysosome assembly
created_by: tanyaberardini
creation_date: 2010-10-27T10:24:28Z

[Term]
id: GO:0090386
name: phagosome maturation involved in apoptotic cell clearance
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the arrangement of constituent parts of a phagosome within a cell and contributes to apoptotic cell clearance. Phagosome maturation begins with endocytosis and formation of the early phagosome and ends with the formation of the hybrid organelle, the phagolysosome." [GOC:kmv, GOC:tb]
is_a: GO:0090382 ! phagosome maturation
intersection_of: GO:0090382 ! phagosome maturation
intersection_of: part_of GO:0043277 ! apoptotic cell clearance
relationship: part_of GO:0043277 ! apoptotic cell clearance
created_by: tanyaberardini
creation_date: 2010-10-27T10:57:39Z

[Term]
id: GO:0090387
name: phagolysosome assembly involved in apoptotic cell clearance
namespace: biological_process
def: "The process in which a phagosome, a vesicle formed by phagocytosis, fuses with a lysosome as a part of apoptotic cell clearance." [GOC:kmv, GOC:tb]
is_a: GO:0001845 ! phagolysosome assembly
intersection_of: GO:0001845 ! phagolysosome assembly
intersection_of: part_of GO:0043277 ! apoptotic cell clearance
relationship: part_of GO:0043277 ! apoptotic cell clearance
relationship: part_of GO:0090386 ! phagosome maturation involved in apoptotic cell clearance
created_by: tanyaberardini
creation_date: 2010-10-27T10:57:39Z

[Term]
id: GO:0090388
name: phagosome-lysosome docking involved in apoptotic cell clearance
namespace: biological_process
def: "The initial attachment of a phagosome membrane to a lysosome membrane that occurs as a part of apoptotic cell clearance. Docking requires only that the proteins come close enough to interact and adhere." [GOC:kmv, GOC:tb]
is_a: GO:0090384 ! phagosome-lysosome docking
intersection_of: GO:0090384 ! phagosome-lysosome docking
intersection_of: part_of GO:0090387 ! phagolysosome assembly involved in apoptotic cell clearance
relationship: part_of GO:0090387 ! phagolysosome assembly involved in apoptotic cell clearance
created_by: tanyaberardini
creation_date: 2010-10-27T10:57:39Z

[Term]
id: GO:0090389
name: phagosome-lysosome fusion involved in apoptotic cell clearance
namespace: biological_process
def: "The creation of a phagolysosome from a phagosome and a lysosome as a part of apoptotic cell clearance." [GOC:kmv, GOC:tb]
is_a: GO:0090385 ! phagosome-lysosome fusion
intersection_of: GO:0090385 ! phagosome-lysosome fusion
intersection_of: part_of GO:0090387 ! phagolysosome assembly involved in apoptotic cell clearance
relationship: part_of GO:0090387 ! phagolysosome assembly involved in apoptotic cell clearance
created_by: tanyaberardini
creation_date: 2010-10-27T10:57:39Z

[Term]
id: GO:0090390
name: phagosome acidification involved in apoptotic cell clearance
namespace: biological_process
def: "Any process that reduces the pH of the phagosome, measured by the concentration of the hydrogen ion, and occurs as a part of apoptotic cell clearance." [GOC:kmv, GOC:tb]
is_a: GO:0090383 ! phagosome acidification
intersection_of: GO:0090383 ! phagosome acidification
intersection_of: part_of GO:0090386 ! phagosome maturation involved in apoptotic cell clearance
relationship: part_of GO:0090386 ! phagosome maturation involved in apoptotic cell clearance
created_by: tanyaberardini
creation_date: 2010-10-27T10:57:39Z

[Term]
id: GO:0090391
name: granum assembly
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly of a granum. A granum is a distinct stack of lamellae seen within chloroplasts." [GOC:tb]
synonym: "grana formation" EXACT [GOC:tb]
is_a: GO:0022607 ! cellular component assembly
relationship: part_of GO:0009658 ! chloroplast organization
created_by: tanyaberardini
creation_date: 2010-12-08T04:25:46Z

[Term]
id: GO:0090392
name: sepal giant cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a sepal giant cell. A sepal giant cell is a pavement cell that is part of the sepal epidermis and stretches one fifth the length of the sepal with a chromosome content of 16C." [GOC:tb, PMID:20485493]
is_a: GO:0090627 ! plant epidermal cell differentiation
created_by: tanyaberardini
creation_date: 2010-12-14T04:38:06Z

[Term]
id: GO:0090393
name: sepal giant cell development
namespace: biological_process
def: "The process aimed at the progression of a sepal giant cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:tb]
synonym: "sepal giant cell formation" RELATED [GOC:tb]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0090392 ! sepal giant cell differentiation
created_by: tanyaberardini
creation_date: 2010-12-14T04:44:34Z

[Term]
id: GO:0090394
name: negative regulation of excitatory postsynaptic potential
namespace: biological_process
def: "Any process that prevents the establishment or decreases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." [GOC:BHF]
synonym: "negative regulation of EPSP" RELATED []
synonym: "negative regulation of excitatory post-synaptic membrane potential" EXACT []
synonym: "reduction of excitatory postsynaptic membrane potential" EXACT [GOC:bf]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0050805 ! negative regulation of synaptic transmission
is_a: GO:0098815 ! modulation of excitatory postsynaptic potential
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: negatively_regulates GO:0060079 ! excitatory postsynaptic potential
relationship: negatively_regulates GO:0060079 ! excitatory postsynaptic potential
created_by: tanyaberardini
creation_date: 2010-12-15T01:43:12Z

[Term]
id: GO:0090395
name: plant cell papilla
namespace: cellular_component
def: "A cell projection that is a short, rounded projection from a plant epidermal cell." [GOC:tb]
comment: Part of papilla cell (PO:0025166), which is a shoot epidermal cell (PO:0025165) in plants. Replaces the obsolete term papillae (PO:0002001).
is_a: GO:0042995 ! cell projection
created_by: tanyaberardini
creation_date: 2010-12-15T03:26:20Z

[Term]
id: GO:0090396
name: leaf papilla
namespace: cellular_component
def: "A plant cell papilla that is part of a leaf papilla cell." [GOC:tb]
comment: Part of leaf papilla cell (PO:0025167).
is_a: GO:0090395 ! plant cell papilla
created_by: tanyaberardini
creation_date: 2010-12-15T03:26:20Z

[Term]
id: GO:0090397
name: stigma papilla
namespace: cellular_component
def: "A plant cell papilla that is part of a stigma papilla cell." [GOC:tb]
comment: Part of stigma papilla cell (PO:0025168).
is_a: GO:0090395 ! plant cell papilla
created_by: tanyaberardini
creation_date: 2010-12-15T03:26:20Z

[Term]
id: GO:0090398
name: cellular senescence
namespace: biological_process
def: "A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest." [GOC:BHF]
is_a: GO:0007569 ! cell aging
is_a: GO:0033554 ! cellular response to stress
created_by: tanyaberardini
creation_date: 2011-01-05T02:27:08Z

[Term]
id: GO:0090399
name: replicative senescence
namespace: biological_process
def: "A cell aging process associated with the dismantling of a cell as a response to telomere shortening and/or cellular aging." [GOC:BHF]
is_a: GO:0007569 ! cell aging
created_by: tanyaberardini
creation_date: 2011-01-05T02:32:29Z

[Term]
id: GO:0090400
name: stress-induced premature senescence
namespace: biological_process
def: "A cellular senescence process associated with the dismantling of a cell as a response to environmental factors such as hydrogen peroxide or X-rays." [GOC:BHF]
synonym: "SIPS" EXACT [GOC:BHF]
is_a: GO:0090398 ! cellular senescence
created_by: tanyaberardini
creation_date: 2011-01-05T02:32:29Z

[Term]
id: GO:0090401
name: viral-induced premature senescence
namespace: biological_process
def: "A cellular senescence process associated with the dismantling of a cell as a response to viral infection." [GOC:BHF]
is_a: GO:0090400 ! stress-induced premature senescence
relationship: part_of GO:0051607 ! defense response to virus
created_by: tanyaberardini
creation_date: 2011-01-05T02:37:57Z

[Term]
id: GO:0090402
name: oncogene-induced cell senescence
namespace: biological_process
def: "A cellular senescence process associated with the dismantling of a cell as a response to oncogenic stress, such as the activation of the Ras oncogenic family." [GOC:BHF]
synonym: "OIS" EXACT [GOC:BHF]
is_a: GO:0090398 ! cellular senescence
created_by: tanyaberardini
creation_date: 2011-01-05T02:37:57Z

[Term]
id: GO:0090403
name: oxidative stress-induced premature senescence
namespace: biological_process
def: "A cellular senescence process associated with the dismantling of a cell as a response to oxidative stress, e.g. high levels of reactive oxygen species, such as superoxide anions, hydrogen peroxide, and hydroxyl radicals." [GOC:BHF]
is_a: GO:0090400 ! stress-induced premature senescence
relationship: part_of GO:0034599 ! cellular response to oxidative stress
created_by: tanyaberardini
creation_date: 2011-01-05T02:37:57Z

[Term]
id: GO:0090404
name: pollen tube tip
namespace: cellular_component
def: "The region at growing end of the pollen tube cell, where polarized growth occurs." [GOC:tb, PO:0025195, PO:0025281]
is_a: GO:0035838 ! growing cell tip
is_a: GO:0044463 ! cell projection part
relationship: part_of GO:0090406 ! pollen tube
created_by: tanyaberardini
creation_date: 2011-01-10T10:25:58Z

[Term]
id: GO:0090405
name: unicellular trichome branch
namespace: cellular_component
def: "A cell projection part that is a branch of a unicellular trichome." [GOC:tb, PO:0025537]
comment: Unicellular trichome (PO:0025537) is a trichome(PO:0000282) that is a single plant cell (PO:0009002). For a cell that forms a branch of a multicellular trichome, see multicellular trichome branch cell (PO:0025163).
is_a: GO:0044463 ! cell projection part
relationship: has_part GO:0090552 ! unicellular trichome apex
created_by: tanyaberardini
creation_date: 2011-01-10T10:30:39Z

[Term]
id: GO:0090406
name: pollen tube
namespace: cellular_component
def: "A tubular cell projection that is part of a pollen tube cell and extends from a pollen grain." [GOC:tb, PO:0025195, PO:0025281]
comment: Carries the male gametes to into or near the ovule. May be branched in gymnosperms. This term replaces the obsolete term PO:0006345. Part of pollen tube cell (PO:0025195).
is_a: GO:0042995 ! cell projection
created_by: tanyaberardini
creation_date: 2011-01-10T01:59:40Z

[Term]
id: GO:0090407
name: organophosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the biosynthesis of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose." [GOC:chem_mtg]
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:1901576 ! organic substance biosynthetic process
created_by: tanyaberardini
creation_date: 2011-02-26T02:22:41Z

[Term]
id: GO:0090408
name: phloem nitrate loading
namespace: biological_process
def: "The process of loading nitrate into the sieve tube or companion cell of the phloem for long distance transport from source to sink." [GOC:tb]
synonym: "phloem loading" BROAD []
is_a: GO:0010233 ! phloem transport
is_a: GO:0015706 ! nitrate transport
created_by: tanyaberardini
creation_date: 2011-06-01T10:06:21Z

[Term]
id: GO:0090409
name: malonyl-CoA synthetase activity
namespace: molecular_function
def: "Catalysis of the reaction: malonate + ATP + coenzyme A = malonyl-CoA + AMP + diphosphate." [MetaCyc:RXN-12359]
xref: EC:6.2.1.-
xref: MetaCyc:RXN-12359
is_a: GO:0016878 ! acid-thiol ligase activity
created_by: tanyaberardini
creation_date: 2011-06-10T01:51:16Z

[Term]
id: GO:0090410
name: malonate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of malonate, the propanedioate ion." [GOC:tb]
is_a: GO:0043649 ! dicarboxylic acid catabolic process
created_by: tanyaberardini
creation_date: 2011-06-10T01:53:43Z

[Term]
id: GO:0090411
name: brassinosteroid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a brassinosteroid." [GOC:tb]
is_a: GO:0005496 ! steroid binding
is_a: GO:0043178 ! alcohol binding
created_by: tanyaberardini
creation_date: 2011-08-11T02:25:30Z

[Term]
id: GO:0090412
name: obsolete positive regulation of transcription from RNA polymerase II promoter involved in fatty acid biosynthetic process
namespace: biological_process
def: "Any positive regulation of transcription from RNA polymerase II promoter that is involved in fatty acid biosynthetic process." [GOC:vw]
synonym: "positive regulation of transcription from RNA polymerase II promoter involved in fatty acid biosynthetic process" EXACT []
is_obsolete: true
created_by: tanyaberardini
creation_date: 2011-09-01T03:10:41Z

[Term]
id: GO:0090413
name: obsolete negative regulation of transcription from RNA polymerase II promoter involved in fatty acid biosynthetic process
namespace: biological_process
def: "Any negative regulation of transcription from RNA polymerase II promoter that is involved in fatty acid biosynthetic process." [GOC:vw]
synonym: "negative regulation of transcription from RNA polymerase II promoter involved in fatty acid biosynthetic process" EXACT []
is_obsolete: true
created_by: tanyaberardini
creation_date: 2011-09-01T03:10:41Z

[Term]
id: GO:0090414
name: molybdate ion export from vacuole
namespace: biological_process
def: "The directed movement of molybdate ions out of the vacuole." [GOC:tb]
is_a: GO:0015689 ! molybdate ion transport
is_a: GO:0034486 ! vacuolar transmembrane transport
is_a: GO:0098661 ! inorganic anion transmembrane transport
created_by: tanyaberardini
creation_date: 2011-09-15T02:08:43Z

[Term]
id: GO:0090415
name: 7-hydroxymethyl chlorophyll a reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7-hydroxymethyl chlorophyll a + 2 reduced ferredoxin + 2 H+ chlorophyll a + 2 oxidized ferredoxin + H2O." [GOC:kad, PMID:21934147]
is_a: GO:0052592 ! oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor
created_by: tanyaberardini
creation_date: 2011-10-03T12:08:27Z

[Term]
id: GO:0090416
name: nicotinate transporter activity
namespace: molecular_function
def: "Enables the directed movement of nicotinate into, out of or within a cell, or between cells." [GOC:tb]
is_a: GO:0022892 ! substrate-specific transporter activity
relationship: part_of GO:2001142 ! nicotinate transport
created_by: tanyaberardini
creation_date: 2011-10-19T11:09:59Z

[Term]
id: GO:0090417
name: N-methylnicotinate transporter activity
namespace: molecular_function
def: "Enables the directed movement of N-methylnicotinate into, out of or within a cell, or between cells." [GOC:tb]
is_a: GO:0022892 ! substrate-specific transporter activity
relationship: part_of GO:2001143 ! N-methylnicotinate transport
created_by: tanyaberardini
creation_date: 2011-10-19T11:09:59Z

[Term]
id: GO:0090418
name: obsolete positive regulation of transcription involved in S-phase of mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription of target genes that are transcribed as part of the S phase of the mitotic cell cycle." [PMID:16912276]
comment: This term was made obsolete because it is unclear exactly what it means. It could mean either 'regulation of transcription during phase X' or 'regulation of transition between phase X and phase Y'.
synonym: "activation of S phase specific transcription in the mitotic cell cycle" RELATED []
synonym: "activation of transcription from RNA polymerase II promoter during S phase of the mitotic cell cycle" RELATED []
synonym: "activation of transcription involved in S phase of mitotic cell cycle" RELATED []
synonym: "positive regulation of S phase specific transcription in the mitotic cell cycle" RELATED []
synonym: "positive regulation of transcription from RNA polymerase II promoter during S phase of the mitotic cell cycle" RELATED []
synonym: "positive regulation of transcription involved in S-phase of mitotic cell cycle" EXACT []
synonym: "up-regulation of S phase specific transcription in the mitotic cell cycle" RELATED []
synonym: "up-regulation of transcription from RNA polymerase II promoter during S phase of the mitotic cell cycle" RELATED []
synonym: "up-regulation of transcription involved in S phase of mitotic cell cycle" RELATED []
is_obsolete: true
created_by: tanyaberardini
creation_date: 2011-10-26T03:54:00Z

[Term]
id: GO:0090419
name: negative regulation of transcription involved in G2/M transition of mitotic cell cycle
namespace: biological_process
def: "Any process that inhibits or decreases the frequency, rate or extent of transcription of target genes that are transcribed as part of the G2/M transition of the mitotic cell cycle." [GOC:mtg_cell_cycle, PMID:10747051]
synonym: "down-regulation of transcription from RNA polymerase II promoter during the G2/M transition of the mitotic cell cycle" RELATED []
synonym: "negative regulation of transcription from RNA polymerase II promoter during G2/M transition of the mitotic cell cycle" RELATED []
is_a: GO:0000117 ! regulation of transcription involved in G2/M transition of mitotic cell cycle
is_a: GO:0045892 ! negative regulation of transcription, DNA-templated
intersection_of: GO:0045892 ! negative regulation of transcription, DNA-templated
intersection_of: part_of GO:0000086 ! G2/M transition of mitotic cell cycle
relationship: part_of GO:0000086 ! G2/M transition of mitotic cell cycle
created_by: tanyaberardini
creation_date: 2011-10-26T03:59:41Z

[Term]
id: GO:0090420
name: naphthalene-containing compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving naphthalene-containing compounds." [GOC:dph, GOC:tb]
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
created_by: tanyaberardini
creation_date: 2011-12-12T11:32:34Z

[Term]
id: GO:0090421
name: embryonic meristem initiation
namespace: biological_process
def: "Initiation of a region of tissue in a plant embryo that is composed of one or more undifferentiated cells capable of undergoing mitosis and differentiation." [GOC:tb]
is_a: GO:0010014 ! meristem initiation
created_by: tanyaberardini
creation_date: 2012-04-13T02:52:34Z

[Term]
id: GO:0090422
name: thiamine pyrophosphate transporter activity
namespace: molecular_function
def: "Enables the directed movement of thiamine pyrophosphate into, out of or within a cell, or between cells." [GOC:tb]
synonym: "thiamine diphosphate transporter activity" EXACT [GOC:tb]
is_a: GO:0045118 ! azole transporter activity
is_a: GO:0051183 ! vitamin transporter activity
relationship: part_of GO:0030974 ! thiamine pyrophosphate transport
created_by: tanyaberardini
creation_date: 2012-04-17T12:28:11Z

[Term]
id: GO:0090423
name: phytochelatin-metal complex formation
namespace: biological_process
def: "A phytochelatin metabolic process in which a metal is incorporated with phytochelatin to form a complex." [GOC:tb]
synonym: "low molecular weight phytochelatin complex formation" RELATED []
synonym: "LWM phytochelatin complex formation" RELATED []
is_a: GO:0046937 ! phytochelatin metabolic process
created_by: tanyaberardini
creation_date: 2012-04-20T03:46:45Z

[Term]
id: GO:0090424
name: phytochelatin-metal-sulfur complex formation
namespace: biological_process
def: "A phytochelatin metabolic process in which a metal and exogenous sulfur are incorporated with phytochelatin to form a complex." [GOC:tb]
synonym: "high molecular weight phytochelatin complex formation" RELATED []
synonym: "HWM phytochelatin complex formation" RELATED []
is_a: GO:0046937 ! phytochelatin metabolic process
created_by: tanyaberardini
creation_date: 2012-04-20T03:46:45Z

[Term]
id: GO:0090425
name: acinar cell differentiation
namespace: biological_process
def: "The epithelial cell differentiation process in which a relatively unspecialized cell acquires specialized features of an acinar cell, a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini." [GOC:dph, GOC:tb]
is_a: GO:0002067 ! glandular epithelial cell differentiation
created_by: tanyaberardini
creation_date: 2012-05-04T09:24:48Z

[Term]
id: GO:0090426
name: actin filament bundle convergence
namespace: biological_process
def: "A process of actin filament bundle distribution that results in the compaction of actin filaments." [GOC:dph, GOC:tb]
is_a: GO:0070650 ! actin filament bundle distribution
created_by: tanyaberardini
creation_date: 2012-05-04T09:33:09Z

[Term]
id: GO:0090427
name: activation of meiosis
namespace: biological_process
def: "Any process that starts the inactive process of meiosis." [GOC:dph, GOC:tb]
is_a: GO:0045836 ! positive regulation of meiotic nuclear division
created_by: tanyaberardini
creation_date: 2012-05-04T09:50:19Z

[Term]
id: GO:0090428
name: perianth development
namespace: biological_process
def: "The process whose specific outcome is the progression of the perianth over time, from its formation to the mature structure. The perianth is a collective phyllome structure composed of two or more petals, sepals, or tepals." [GOC:tb, PO:0009058]
is_a: GO:0048438 ! floral whorl development
relationship: part_of GO:0009908 ! flower development
created_by: tanyaberardini
creation_date: 2012-05-08T06:02:15Z

[Term]
id: GO:0090429
name: detection of endogenous biotic stimulus
namespace: biological_process
def: "The series of events in which an endogenous biotic stimulus is received by a cell and converted into a molecular signal." [GOC:dph, GOC:tb]
is_a: GO:0009595 ! detection of biotic stimulus
is_a: GO:0009726 ! detection of endogenous stimulus
created_by: tanyaberardini
creation_date: 2012-05-11T09:19:39Z

[Term]
id: GO:0090430
name: caffeoyl-CoA: alcohol caffeoyl transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: caffeoyl-CoA + a saturated primary alcohol = an alkyl caffeate + CoA." [GOC:pz]
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups
created_by: tanyaberardini
creation_date: 2012-07-25T10:48:15Z

[Term]
id: GO:0090431
name: alkyl caffeate ester biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ester derivatives of alkyl caffeate." [GOC:pz]
synonym: "alkyl caffeate ester anabolism" EXACT [GOC:tb]
synonym: "alkyl caffeate ester biosynthesis" EXACT [GOC:tb]
synonym: "alkyl caffeate ester formation" EXACT [GOC:tb]
synonym: "alkyl caffeate ester synthesis" EXACT [GOC:tb]
is_a: GO:0009713 ! catechol-containing compound biosynthetic process
is_a: GO:0009802 ! cinnamic acid ester biosynthetic process
created_by: tanyaberardini
creation_date: 2012-07-25T11:12:09Z

[Term]
id: GO:0090432
name: myristoyl-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + myristic acid + CoA = AMP + diphosphate + myristoyl-CoA." [GOC:al, PMID:18071249]
synonym: "myristoyl-CoA synthetase activity" EXACT []
is_a: GO:0004467 ! long-chain fatty acid-CoA ligase activity
created_by: tanyaberardini
creation_date: 2012-07-25T03:31:31Z

[Term]
id: GO:0090433
name: palmitoyl-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + palmitic acid + CoA = AMP + diphosphate + palmitoyl-CoA." [GOC:al, PMID:18071249]
synonym: "palmitoyl-CoA synthetase activity" EXACT []
is_a: GO:0004467 ! long-chain fatty acid-CoA ligase activity
created_by: tanyaberardini
creation_date: 2012-07-25T03:31:31Z

[Term]
id: GO:0090434
name: oleoyl-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + oleic acid + CoA = AMP + diphosphate + oleoyl-CoA." [GOC:al, PMID:18071249]
synonym: "oleoyl-CoA synthetase activity" EXACT []
is_a: GO:0004467 ! long-chain fatty acid-CoA ligase activity
created_by: tanyaberardini
creation_date: 2012-07-25T03:31:31Z

[Term]
id: GO:0090435
name: protein localization to nuclear envelope
namespace: biological_process
def: "A process in which a protein is transported to, or maintained at, a location within a nuclear envelope." [GOC:tb]
synonym: "protein localization in nuclear envelope" EXACT [GOC:curators]
is_a: GO:0034504 ! protein localization to nucleus
relationship: part_of GO:0006998 ! nuclear envelope organization
created_by: tanyaberardini
creation_date: 2012-07-30T01:50:41Z

[Term]
id: GO:0090436
name: leaf pavement cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of an leaf pavement cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a leaf pavement cell fate." [GOC:tb]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0048366 ! leaf development
created_by: tanyaberardini
creation_date: 2012-07-31T16:08:53Z

[Term]
id: GO:0090437
name: socket cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a socket cell, a shoot epidermal cell that surrounds a trichome and provides its support." [GOC:tb]
is_a: GO:0090627 ! plant epidermal cell differentiation
relationship: part_of GO:0090558 ! plant epidermis development
created_by: tanyaberardini
creation_date: 2012-07-31T17:01:28Z

[Term]
id: GO:0090438
name: camelliol C synthase activity
namespace: molecular_function
def: "Catalyzes the reaction: (3S)-2,3-epoxy-2,3-dihydrosqualene = camelliol C." [GOC:tb, PMID:17985917]
synonym: "(3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, camelliol-C-forming)" EXACT []
is_a: GO:0016866 ! intramolecular transferase activity
created_by: tanyaberardini
creation_date: 2012-08-08T15:41:45Z

[Term]
id: GO:0090439
name: tetraketide alpha-pyrone synthase activity
namespace: molecular_function
def: "Catalyzes the reaction: a hydroxyacyl-CoA + 3 malonyl-CoA + 2 H+ = a hydroxylated tetraketide alpha-pyrone + 3 CO2 + 4 coenzyme A ." [MetaCyc:RXN-12183, PMID:21193570]
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups
created_by: tanyaberardini
creation_date: 2012-08-09T14:35:06Z

[Term]
id: GO:0090440
name: abscisic acid transporter activity
namespace: molecular_function
def: "Enables the directed movement of abscisic acid into, out of or within a cell, or between cells." [GOC:tb]
is_a: GO:0005319 ! lipid transporter activity
relationship: part_of GO:0080168 ! abscisic acid transport
created_by: tanyaberardini
creation_date: 2012-08-20T14:29:42Z

[Term]
id: GO:0090441
name: trehalose biosynthesis in response to heat stress
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of trehalose that occur as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:dph, GOC:tb]
synonym: "trehalose biosynthetic process in response to heat stress" EXACT systematic_synonym [GOC:tb]
is_a: GO:0005992 ! trehalose biosynthetic process
is_a: GO:0070414 ! trehalose metabolism in response to heat stress
created_by: tanyaberardini
creation_date: 2012-08-23T13:53:07Z

[Term]
id: GO:0090442
name: trehalose catabolism in response to heat stress
namespace: biological_process
def: "The chemical reactions and pathways resulting in the degradation of trehalose that occur as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:dph, GOC:tb]
synonym: "trehalose catabolic process in response to heat stress" EXACT systematic_synonym [GOC:tb]
is_a: GO:0070414 ! trehalose metabolism in response to heat stress
is_a: GO:1903134 ! trehalose catabolic process involved in cellular response to stress
relationship: part_of GO:0010353 ! response to trehalose
created_by: tanyaberardini
creation_date: 2012-08-23T13:53:07Z

[Term]
id: GO:0090443
name: FAR/SIN/STRIPAK complex
namespace: cellular_component
def: "A conserved protein phosphatase type 2A complex which contains a protein phosphatase type 2A, a protein phosphatase regulatory subunit, a striatin, an FHA domain protein and other subunits (at least six proteins). In fission yeast this complex negatively regulate the septation initiation network at the spindle pole body." [GOC:vw, PMID:21561862, PMID:22119525]
synonym: "FAR complex" RELATED [GOC:vw]
synonym: "SIP complex" EXACT [PMID:22119525]
synonym: "striatin interacting phosphatase and kinase complex" EXACT [GOC:vw]
synonym: "STRIPAK signalling complex" RELATED [GOC:vw]
is_a: GO:0043234 ! protein complex
created_by: tanyaberardini
creation_date: 2012-08-23T14:20:39Z

[Term]
id: GO:0090444
name: regulation of nematode larval development, heterochronic
namespace: biological_process
def: "Any process that modulates the consistent predetermined time point at which a nematode larva progresses from an initial condition to a later condition and the rate at which this time point is reached." [PMID:17550772]
is_a: GO:0040034 ! regulation of development, heterochronic
is_a: GO:0061062 ! regulation of nematode larval development
created_by: tanyaberardini
creation_date: 2012-08-24T13:24:43Z

[Term]
id: GO:0090445
name: positive regulation of nematode larval development, heterochronic
namespace: biological_process
def: "Any process that modulates the consistent predetermined time point at which a nematode larva progresses from an initial condition to a later condition and increases the rate at which this time point is reached." [PMID:17550772]
is_a: GO:0045962 ! positive regulation of development, heterochronic
is_a: GO:0061063 ! positive regulation of nematode larval development
is_a: GO:0090444 ! regulation of nematode larval development, heterochronic
created_by: tanyaberardini
creation_date: 2012-08-24T13:24:43Z

[Term]
id: GO:0090446
name: negative regulation of nematode larval development, heterochronic
namespace: biological_process
def: "Any process that modulates the consistent predetermined time point at which a nematode larva progresses from an initial condition to a later condition and decreases the rate at which this time point is reached." [PMID:17550772]
is_a: GO:0045961 ! negative regulation of development, heterochronic
is_a: GO:0061064 ! negative regulation of nematode larval development
is_a: GO:0090444 ! regulation of nematode larval development, heterochronic
created_by: tanyaberardini
creation_date: 2012-08-24T13:24:43Z

[Term]
id: GO:0090447
name: glycerol-3-phosphate 2-O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: an acyl-CoA + sn-glycerol 3-phosphate = CoA + a 2-acyl-sn-glycerol 3-phosphate." [EC:2.3.1.198]
is_a: GO:0008374 ! O-acyltransferase activity
created_by: tanyaberardini
creation_date: 2012-08-31T09:23:12Z

[Term]
id: GO:0090448
name: glucosinolate:proton symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucosinolate(out) + H+(out) = glucosinolate(in) + H+(in)." [PMID:22864417]
synonym: "glucosinolate:hydrogen symporter activity" EXACT []
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015295 ! solute:proton symporter activity
is_a: GO:0015296 ! anion:cation symporter activity
is_a: GO:1901505 ! carbohydrate derivative transporter activity
is_a: GO:1901682 ! sulfur compound transmembrane transporter activity
relationship: part_of GO:1901349 ! glucosinolate transport
created_by: tanyaberardini
creation_date: 2012-09-07T16:10:37Z

[Term]
id: GO:0090449
name: phloem glucosinolate loading
namespace: biological_process
def: "The process of loading glucosinolates into the sieve tube or companion cell of the phloem for long distance transport from source to sink." [PMID:22864417]
is_a: GO:0010233 ! phloem transport
created_by: tanyaberardini
creation_date: 2012-09-07T16:21:22Z

[Term]
id: GO:0090450
name: inosine-diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: IDP + H2O = IMP + phosphate." [PMID:22849572]
synonym: "IDPase activity" EXACT []
synonym: "inosine diphosphatase activity" EXACT []
is_a: GO:0017110 ! nucleoside-diphosphatase activity
created_by: tanyaberardini
creation_date: 2012-09-12T08:30:52Z

[Term]
id: GO:0090451
name: cotyledon boundary formation
namespace: biological_process
def: "The process in which boundaries between a cotyledon and the surrounding tissue are established and maintained." [GOC:tb]
is_a: GO:0010160 ! formation of organ boundary
created_by: tanyaberardini
creation_date: 2012-09-19T10:26:54Z

[Term]
id: GO:0090452
name: lithium ion import
namespace: biological_process
def: "The directed movement of lithium ions into a cell or organelle." [GOC:tb]
synonym: "lithium ion uptake" EXACT [GOC:tb]
is_a: GO:0010351 ! lithium ion transport
created_by: tanyaberardini
creation_date: 2012-09-24T14:04:41Z

[Term]
id: GO:0090453
name: aspartate transmembrane import into vacuole
namespace: biological_process
def: "The directed movement of aspartate into the vacuole across the vacuolar membrane." [GOC:tb]
synonym: "vacuolar aspartate import" EXACT [GOC:tb]
is_a: GO:0015810 ! aspartate transport
is_a: GO:0032975 ! amino acid transmembrane import into vacuole
created_by: tanyaberardini
creation_date: 2012-09-24T14:12:46Z

[Term]
id: GO:0090454
name: glutamate transmembrane import into vacuole
namespace: biological_process
def: "The directed movement of glutamate into the vacuole across the vacuolar membrane." [GOC:tb]
synonym: "vacuolar glutamate import" RELATED [GOC:tb]
is_a: GO:0006835 ! dicarboxylic acid transport
is_a: GO:0015800 ! acidic amino acid transport
is_a: GO:0032975 ! amino acid transmembrane import into vacuole
created_by: tanyaberardini
creation_date: 2012-09-24T14:12:46Z

[Term]
id: GO:0090455
name: ornithine transmembrane import into vacuole
namespace: biological_process
def: "The directed movement of ornithine into the vacuole across the vacuolar membrane." [GOC:tb]
synonym: "vacuolar ornithine import" RELATED [GOC:tb]
is_a: GO:0015822 ! ornithine transport
is_a: GO:0032975 ! amino acid transmembrane import into vacuole
is_a: GO:0098655 ! cation transmembrane transport
created_by: tanyaberardini
creation_date: 2012-09-24T14:12:46Z

[Term]
id: GO:0090456
name: lysine transmembrane import into vacuole
namespace: biological_process
def: "The directed movement of lysine into the vacuole across the vacuolar membrane." [GOC:tb]
synonym: "vacuolar lysine import" EXACT [GOC:tb]
is_a: GO:0034226 ! lysine import
is_a: GO:0034490 ! basic amino acid transmembrane import into vacuole
is_a: GO:0098655 ! cation transmembrane transport
created_by: tanyaberardini
creation_date: 2012-09-24T14:12:46Z

[Term]
id: GO:0090457
name: histidine transmembrane import into vacuole
namespace: biological_process
def: "The directed movement of histidine into the vacuole across the vacuolar membrane." [GOC:tb]
synonym: "vacuolar histidine import" EXACT [GOC:tb]
is_a: GO:0034490 ! basic amino acid transmembrane import into vacuole
is_a: GO:0090466 ! histidine import
is_a: GO:0098655 ! cation transmembrane transport
created_by: tanyaberardini
creation_date: 2012-09-24T14:12:46Z

[Term]
id: GO:0090458
name: arginine transmembrane import into vacuole
namespace: biological_process
def: "The directed movement of arginine into the vacuole across the vacuolar membrane." [GOC:tb]
synonym: "vacuolar arginine import" EXACT [GOC:tb]
is_a: GO:0034490 ! basic amino acid transmembrane import into vacuole
is_a: GO:0090467 ! arginine import
is_a: GO:1903826 ! arginine transmembrane transport
created_by: tanyaberardini
creation_date: 2012-09-24T14:12:46Z

[Term]
id: GO:0090459
name: aspartate homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of aspartate within an organism or cell." [GOC:tb]
is_a: GO:0080144 ! amino acid homeostasis
created_by: tanyaberardini
creation_date: 2012-09-24T14:22:02Z

[Term]
id: GO:0090460
name: threonine homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of threonine within an organism or cell." [GOC:tb]
is_a: GO:0055080 ! cation homeostasis
is_a: GO:0080144 ! amino acid homeostasis
created_by: tanyaberardini
creation_date: 2012-09-24T14:22:02Z

[Term]
id: GO:0090461
name: glutamate homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of glutamate within an organism or cell." [GOC:tb]
is_a: GO:0080144 ! amino acid homeostasis
created_by: tanyaberardini
creation_date: 2012-09-24T14:22:02Z

[Term]
id: GO:0090462
name: ornithine homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of ornithine within an organism or cell." [GOC:tb]
is_a: GO:0055080 ! cation homeostasis
is_a: GO:0080144 ! amino acid homeostasis
created_by: tanyaberardini
creation_date: 2012-09-24T14:22:02Z

[Term]
id: GO:0090463
name: lysine homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of lysine within an organism or cell." [GOC:tb]
is_a: GO:0055080 ! cation homeostasis
is_a: GO:0080144 ! amino acid homeostasis
created_by: tanyaberardini
creation_date: 2012-09-24T14:22:02Z

[Term]
id: GO:0090464
name: histidine homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of histidine within an organism or cell." [GOC:tb]
is_a: GO:0055080 ! cation homeostasis
is_a: GO:0080144 ! amino acid homeostasis
created_by: tanyaberardini
creation_date: 2012-09-24T14:22:02Z

[Term]
id: GO:0090465
name: arginine homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of arginine within an organism or cell." [GOC:tb]
is_a: GO:0055080 ! cation homeostasis
is_a: GO:0080144 ! amino acid homeostasis
created_by: tanyaberardini
creation_date: 2012-09-24T14:22:02Z

[Term]
id: GO:0090466
name: histidine import
namespace: biological_process
def: "The directed movement of histidine into a cell or organelle." [GOC:tb]
is_a: GO:0015817 ! histidine transport
is_a: GO:0043090 ! amino acid import
created_by: tanyaberardini
creation_date: 2012-09-24T14:28:58Z

[Term]
id: GO:0090467
name: arginine import
namespace: biological_process
def: "The directed movement of arginine into a cell or organelle." [GOC:tb]
is_a: GO:0015809 ! arginine transport
is_a: GO:0043090 ! amino acid import
created_by: tanyaberardini
creation_date: 2012-09-24T14:28:58Z

[Term]
id: GO:0090468
name: valine import
namespace: biological_process
def: "The directed movement of valine into a cell or organelle." [GOC:tb]
is_a: GO:0015829 ! valine transport
is_a: GO:0043090 ! amino acid import
created_by: tanyaberardini
creation_date: 2012-09-24T14:28:58Z

[Term]
id: GO:0090469
name: asparagine import
namespace: biological_process
def: "The directed movement of asparagine into a cell or organelle." [GOC:tb]
is_a: GO:0006867 ! asparagine transport
is_a: GO:0043090 ! amino acid import
created_by: tanyaberardini
creation_date: 2012-09-24T14:28:58Z

[Term]
id: GO:0090470
name: shoot organ boundary specification
namespace: biological_process
def: "The process in which the basal boundary between the stem and both vegetative and reproductive organs are established and maintained." [PMID:18757555]
is_a: GO:0010160 ! formation of organ boundary
created_by: tanyaberardini
creation_date: 2012-09-24T16:22:03Z

[Term]
id: GO:0090471
name: 9,15,9'-tri-cis-zeta-carotene isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 9,15,9'-tricis-zeta-carotene = 9,9'-dicis-zeta-carotene." [EC:5.2.1.12]
synonym: "9,15,9'-tricis-zeta-carotene cis-trans-isomerase" RELATED []
is_a: GO:0016859 ! cis-trans isomerase activity
created_by: tanyaberardini
creation_date: 2012-09-24T16:29:49Z

[Term]
id: GO:0090472
name: dibasic protein processing
namespace: biological_process
def: "Any protein processing achieved by the cleavage of a peptide bond after two basic amino acids within a protein." [GOC:al]
is_a: GO:0016485 ! protein processing
created_by: tanyaberardini
creation_date: 2012-10-01T10:39:26Z

[Term]
id: GO:0090473
name: lys-arg specific dibasic protein processing
namespace: biological_process
def: "Any protein processing achieved by the cleavage of a peptide bond after a lysine-arginine amino acid residue combination within a protein." [GOC:al]
is_a: GO:0090472 ! dibasic protein processing
created_by: tanyaberardini
creation_date: 2012-10-01T10:42:30Z

[Term]
id: GO:0090474
name: arg-arg specific dibasic protein processing
namespace: biological_process
def: "Any protein processing achieved by the cleavage of a peptide bond after two consecutive arginine amino acid residues within a protein." [GOC:al]
is_a: GO:0090472 ! dibasic protein processing
created_by: tanyaberardini
creation_date: 2012-10-01T10:42:30Z

[Term]
id: GO:0090475
name: lys-lys specific dibasic protein processing
namespace: biological_process
def: "Any protein processing achieved by the cleavage of a peptide bond after two consecutive lysine amino acid residues within a protein." [GOC:al]
is_a: GO:0090472 ! dibasic protein processing
created_by: tanyaberardini
creation_date: 2012-10-01T10:42:30Z

[Term]
id: GO:0090476
name: isoleucine import
namespace: biological_process
def: "The directed movement of isoleucine into a cell or organelle." [GOC:tb]
is_a: GO:0015818 ! isoleucine transport
is_a: GO:0043090 ! amino acid import
created_by: tanyaberardini
creation_date: 2012-10-01T11:10:51Z

[Term]
id: GO:0090477
name: L-isoleucine import
namespace: biological_process
def: "The directed movement of L-isoleucine, the L-enantiomer of isoleucine, into a cell or organelle." [GOC:mah]
is_a: GO:0043092 ! L-amino acid import
is_a: GO:0090476 ! isoleucine import
created_by: tanyaberardini
creation_date: 2012-10-01T11:10:51Z

[Term]
id: GO:0090478
name: serine import
namespace: biological_process
def: "The directed movement of serine into a cell or organelle." [GOC:tb]
is_a: GO:0032329 ! serine transport
is_a: GO:0043090 ! amino acid import
created_by: tanyaberardini
creation_date: 2012-10-01T11:10:51Z

[Term]
id: GO:0090479
name: L-serine import
namespace: biological_process
def: "The directed movement of L-serine, the L-enantiomer of serine, into a cell or organelle." [GOC:mah]
is_a: GO:0015825 ! L-serine transport
is_a: GO:0043092 ! L-amino acid import
is_a: GO:0090478 ! serine import
created_by: tanyaberardini
creation_date: 2012-10-01T11:10:51Z

[Term]
id: GO:0090480
name: purine nucleotide-sugar transmembrane transport
namespace: biological_process
def: "The directed movement of a purine nucleotide-sugar across a membrane. Purine nucleotide-sugars are purine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:tb]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "purine nucleotide-sugar membrane transport" EXACT []
is_a: GO:0036079 ! purine nucleotide-sugar transport
is_a: GO:0072530 ! purine-containing compound transmembrane transport
is_a: GO:1901679 ! nucleotide transmembrane transport
created_by: tanyaberardini
creation_date: 2012-10-01T16:29:44Z

[Term]
id: GO:0090481
name: pyrimidine nucleotide-sugar transmembrane transport
namespace: biological_process
def: "The directed movement of pyrimidine nucleotide-sugars across a membrane. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:tb]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "pyrimidine nucleotide-sugar membrane transport" EXACT []
is_a: GO:0015781 ! pyrimidine nucleotide-sugar transport
is_a: GO:0072531 ! pyrimidine-containing compound transmembrane transport
is_a: GO:1901679 ! nucleotide transmembrane transport
created_by: tanyaberardini
creation_date: 2012-10-01T16:43:54Z

[Term]
id: GO:0090482
name: vitamin transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a vitamin from one side of a membrane to the other." [GOC:tb]
is_a: GO:0022857 ! transmembrane transporter activity
is_a: GO:0051183 ! vitamin transporter activity
relationship: part_of GO:0035461 ! vitamin transmembrane transport
created_by: tanyaberardini
creation_date: 2012-10-02T16:50:50Z

[Term]
id: GO:0090483
name: phosphatidylglycerol-phosphatidylethanolamine phosphatidyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphatidylglycerol + phosphatidylethanolamine = cardiolipin + ethanolamine." [PMID:22988102]
synonym: "cardiolipin synthase" RELATED [GOC:tb]
is_a: GO:0030572 ! phosphatidyltransferase activity
created_by: tanyaberardini
creation_date: 2012-10-03T14:20:05Z

[Term]
id: GO:0090484
name: drug transporter activity
namespace: molecular_function
def: "Enables the directed movement of a drug into, out of or within a cell, or between cells. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease." [GOC:tb]
is_a: GO:0005215 ! transporter activity
relationship: part_of GO:0015893 ! drug transport
created_by: tanyaberardini
creation_date: 2012-10-04T15:29:23Z

[Term]
id: GO:0090485
name: chromosome number maintenance
namespace: biological_process
def: "The maintenance of the standard number of chromosomes in a cell." [GOC:tb]
synonym: "diploidization" RELATED [GOC:tb]
synonym: "haploidization" RELATED [GOC:tb]
is_a: GO:0044763 ! single-organism cellular process
created_by: tanyaberardini
creation_date: 2012-10-05T11:21:45Z

[Term]
id: GO:0090486
name: small RNA 2'-O-methyltransferase
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the oxygen atom of a nucleoside residue in a small RNA molecule. Reaction: S-adenosyl-L-methionine + small RNA <=> S-adenosyl-L-homocysteine + small RNA containing a 3'-terminal 2'-O-methylnucleotide." [EC:2.1.1.n8, GOC:tb, GOC:vw]
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0008173 ! RNA methyltransferase activity
created_by: tanyaberardini
creation_date: 2012-10-15T16:32:49Z

[Term]
id: GO:0090487
name: secondary metabolite catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon." [GOC:tb]
synonym: "secondary metabolite breakdown" EXACT [GOC:tb]
synonym: "secondary metabolite catabolism" EXACT [GOC:tb]
synonym: "secondary metabolite degradation" EXACT [GOC:tb]
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0044712 ! single-organism catabolic process
created_by: tanyaberardini
creation_date: 2012-10-15T16:43:09Z

[Term]
id: GO:0090488
name: polo box domain specific binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a polo box domain of a protein. The polo box domain is involved in binding substrates of polo kinases." [GOC:al, GOC:tb, Pfam:PF00659, PMID:12352953]
is_a: GO:0019904 ! protein domain specific binding
created_by: tanyaberardini
creation_date: 2012-10-16T10:47:30Z

[Term]
id: GO:0090489
name: L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating, decarboxylating)
namespace: molecular_function
def: "Catalyzes the multi-step reaction: L-Tryptophan + 2 Oxygen + 2 NADPH + 2 H+ = Indole-3-acetaldehyde oxime + 3 H2O + 2 NADP+ + CO2. The individual reactions are: (1a) L-tryptophan + O2 + NADPH + H+ = N-hydroxy-L-tryptophan + NADP+ + H2O,(1b) N-hydroxy-L-tryptophan + O2 + NADPH + H+ = N,N-dihydroxy-L-tryptophan + NADP+ + H2O, and (1c) N,N-dihydroxy-L-tryptophan = (E)-indol-3-ylacetaldoxime + CO2 + H2O." [EC:1.14.13.125, KEGG:R08160]
synonym: "tryptophan N-monooxygenase activity" RELATED []
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
relationship: has_part GO:0090490 ! L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating)
relationship: has_part GO:0090491 ! N-hydroxy-L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating)
relationship: has_part GO:0090492 ! N,N-Dihydroxy-L-tryptophan decarboxylase activity
created_by: tanyaberardini
creation_date: 2012-10-16T16:22:19Z

[Term]
id: GO:0090490
name: L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating)
namespace: molecular_function
def: "Catalyzes the reaction: L-Tryptophan + Oxygen + NADPH + H+ = N-Hydroxy-L-tryptophan + NADP+ + H2O." [KEGG:R09583]
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
created_by: tanyaberardini
creation_date: 2012-10-16T16:27:19Z

[Term]
id: GO:0090491
name: N-hydroxy-L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating)
namespace: molecular_function
def: "Catalyzes the reaction: N-Hydroxy-L-tryptophan + Oxygen + NADPH + H+ = N,N-Dihydroxy-L-tryptophan + NADP+ + H2O." [KEGG:R09584]
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
created_by: tanyaberardini
creation_date: 2012-10-16T16:27:19Z

[Term]
id: GO:0090492
name: N,N-Dihydroxy-L-tryptophan decarboxylase activity
namespace: molecular_function
def: "Catalyzes the reaction: N,N-Dihydroxy-L-tryptophan = Indole-3-acetaldehyde oxime + CO2 + H2O." [KEGG:R09585]
is_a: GO:0016831 ! carboxy-lyase activity
created_by: tanyaberardini
creation_date: 2012-10-16T16:32:30Z

[Term]
id: GO:0090493
name: catecholamine uptake
namespace: biological_process
def: "The directed movement of catecholamine into a cell." [GOC:dph, GOC:tb]
is_a: GO:0051937 ! catecholamine transport
created_by: tanyaberardini
creation_date: 2012-10-17T11:06:17Z

[Term]
id: GO:0090494
name: dopamine uptake
namespace: biological_process
def: "The directed movement of dopamine into a cell." [GOC:dph, GOC:tb]
is_a: GO:0015872 ! dopamine transport
is_a: GO:0090493 ! catecholamine uptake
created_by: tanyaberardini
creation_date: 2012-10-17T11:12:09Z

[Term]
id: GO:0090495
name: low-density lipoprotein particle disassembly
namespace: biological_process
def: "The disaggregation of a low-density lipoprotein particle into its constituent components." [GOC:dph, GOC:tb]
is_a: GO:0071829 ! plasma lipoprotein particle disassembly
created_by: tanyaberardini
creation_date: 2012-10-17T11:48:56Z

[Term]
id: GO:0090496
name: mesenchyme migration involved in limb bud formation
namespace: biological_process
def: "The migration of mesenchymal tissue that contributes to the formation of a limb bud." [GOC:dph, GOC:tb]
is_a: GO:0090131 ! mesenchyme migration
intersection_of: GO:0090131 ! mesenchyme migration
intersection_of: part_of GO:0060174 ! limb bud formation
relationship: part_of GO:0060174 ! limb bud formation
created_by: tanyaberardini
creation_date: 2012-10-17T12:04:20Z

[Term]
id: GO:0090497
name: mesenchymal cell migration
namespace: biological_process
def: "The orderly movement of a mesenchymal cell from one site to another, often during the development of a multicellular organism." [GOC:dph, GOC:tb]
is_a: GO:0001667 ! ameboidal-type cell migration
created_by: tanyaberardini
creation_date: 2012-10-17T12:08:17Z

[Term]
id: GO:0090498
name: extrinsic component of Golgi membrane
namespace: cellular_component
def: "The component of a Golgi membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, PMID:21337012]
synonym: "extrinsic to Golgi membrane" NARROW []
is_a: GO:0031312 ! extrinsic component of organelle membrane
is_a: GO:0044431 ! Golgi apparatus part
intersection_of: GO:0019898 ! extrinsic component of membrane
intersection_of: part_of GO:0000139 ! Golgi membrane
relationship: part_of GO:0000139 ! Golgi membrane
created_by: tanyaberardini
creation_date: 2012-10-18T14:12:48Z

[Term]
id: GO:0090499
name: pimelyl-[acyl-carrier protein] methyl ester esterase activity
namespace: molecular_function
def: "Catalysis of the reaction: pimelyl-[acyl-carrier protein] methyl ester + H2O = pimelyl-[acyl-carrier protein] + methanol." [EC:3.1.1.85, PMID:23045647]
synonym: "pimelyl-[acyl-carrier protein] methyl ester hydrolase activity" RELATED []
is_a: GO:0052689 ! carboxylic ester hydrolase activity
created_by: tanyaberardini
creation_date: 2012-10-19T12:10:01Z

[Term]
id: GO:0090500
name: endocardial cushion to mesenchymal transition
namespace: biological_process
def: "A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:dph, GOC:tb]
is_a: GO:0060317 ! cardiac epithelial to mesenchymal transition
created_by: tanyaberardini
creation_date: 2012-10-22T11:51:44Z

[Term]
id: GO:0090501
name: RNA phosphodiester bond hydrolysis
namespace: biological_process
def: "The RNA metabolic process in which the phosphodiester bonds between ribonucleotides are cleaved by hydrolysis." [GOC:dph, GOC:tb]
is_a: GO:0016070 ! RNA metabolic process
is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis
created_by: tanyaberardini
creation_date: 2012-10-22T12:05:27Z

[Term]
id: GO:0090502
name: RNA phosphodiester bond hydrolysis, endonucleolytic
namespace: biological_process
def: "The chemical reactions and pathways involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides." [GOC:dph, GOC:tb]
is_a: GO:0090501 ! RNA phosphodiester bond hydrolysis
created_by: tanyaberardini
creation_date: 2012-10-22T12:05:27Z

[Term]
id: GO:0090503
name: RNA phosphodiester bond hydrolysis, exonucleolytic
namespace: biological_process
def: "The chemical reactions and pathways involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides." [GOC:dph, GOC:tb]
is_a: GO:0090501 ! RNA phosphodiester bond hydrolysis
created_by: tanyaberardini
creation_date: 2012-10-22T12:05:27Z

[Term]
id: GO:0090504
name: epiboly
namespace: biological_process
def: "The expansion of one cell sheet over other cells or yolk." [GOC:dph, GOC:tb]
is_a: GO:0002011 ! morphogenesis of an epithelial sheet
created_by: tanyaberardini
creation_date: 2012-10-22T12:29:52Z

[Term]
id: GO:0090505
name: epiboly involved in wound healing
namespace: biological_process
def: "The expansion of one cell sheet over other cells involved in wound healing." [GOC:dph, GOC:tb]
is_a: GO:0090504 ! epiboly
intersection_of: GO:0090504 ! epiboly
intersection_of: part_of GO:0042060 ! wound healing
relationship: part_of GO:0042060 ! wound healing
created_by: tanyaberardini
creation_date: 2012-10-22T12:38:51Z

[Term]
id: GO:0090506
name: axillary shoot meristem initiation
namespace: biological_process
def: "A developmental process that results in the initiation of an axillary shoot meristem. An axillary shoot meristem is a shoot meristem formed in the axil of a leaf." [GOC:tb]
synonym: "axillary bud meristem initiation" RELATED []
is_a: GO:0010014 ! meristem initiation
relationship: part_of GO:0010223 ! secondary shoot formation
created_by: tanyaberardini
creation_date: 2012-10-23T14:47:00Z

[Term]
id: GO:0090507
name: phenylethylamine metabolic process involved in synaptic transmission
namespace: biological_process
def: "The chemical reactions and pathways involving phenylethylamine that contribute to synaptic transmission." [GOC:tb]
is_a: GO:0042133 ! neurotransmitter metabolic process
is_a: GO:0042443 ! phenylethylamine metabolic process
intersection_of: GO:0042443 ! phenylethylamine metabolic process
intersection_of: part_of GO:0007268 ! synaptic transmission
relationship: part_of GO:0007268 ! synaptic transmission
created_by: tanyaberardini
creation_date: 2012-11-15T15:06:08Z

[Term]
id: GO:0090508
name: phenylethylamine biosynthetic process involved in synaptic transmission
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phenylethylamine that contribute to synaptic transmission." [GOC:tb]
is_a: GO:0042136 ! neurotransmitter biosynthetic process
is_a: GO:0042444 ! phenylethylamine biosynthetic process
is_a: GO:0090507 ! phenylethylamine metabolic process involved in synaptic transmission
intersection_of: GO:0042444 ! phenylethylamine biosynthetic process
intersection_of: part_of GO:0007268 ! synaptic transmission
relationship: part_of GO:0007268 ! synaptic transmission
created_by: tanyaberardini
creation_date: 2012-11-15T15:10:23Z

[Term]
id: GO:0090509
name: nickel cation import into cell
namespace: biological_process
def: "The directed movement of nickel cations from outside of a cell into the intracellular region of a cell.." [GOC:mah]
is_a: GO:0035444 ! nickel cation transmembrane transport
created_by: tanyaberardini
creation_date: 2012-11-16T16:12:53Z

[Term]
id: GO:0090510
name: anticlinal cell division
namespace: biological_process
def: "A cell division process where the division plane is perpendicular to the surface of the organ. It adds cells to the existing cell layer or cell file." [GOC:tair_curators, PMID:21391814]
is_a: GO:0051301 ! cell division
created_by: tanyaberardini
creation_date: 2012-11-21T11:52:40Z

[Term]
id: GO:0090511
name: periclinal cell division
namespace: biological_process
def: "A cell division process where the division plane is parallel to the surface of the organ. It creates a new cell layer or cell file." [GOC:tair_curators, PMID:21391814]
is_a: GO:0051301 ! cell division
created_by: tanyaberardini
creation_date: 2012-11-21T11:52:40Z

[Term]
id: GO:0090512
name: eisosome membrane domain/MCC
namespace: cellular_component
def: "A plasma membrane part that is composed of a furrow-like plasma membrane domain and associated integral transmembrane proteins." [GOC:al, GOC:vw, PMID:22368779]
is_a: GO:0044853 ! plasma membrane raft
relationship: part_of GO:0032126 ! eisosome
created_by: tanyaberardini
creation_date: 2012-12-07T17:00:19Z

[Term]
id: GO:0090513
name: L-histidine transmembrane import into vacuole
namespace: biological_process
def: "The directed movement of L-histidine into the vacuole across the vacuolar membrane." [GOC:al]
is_a: GO:0089709 ! L-histidine transmembrane transport
is_a: GO:0090457 ! histidine transmembrane import into vacuole
is_a: GO:1903810 ! L-histidine import into cell
created_by: tanyaberardini
creation_date: 2012-12-14T11:25:52Z

[Term]
id: GO:0090514
name: L-tyrosine transmembrane import into vacuole
namespace: biological_process
def: "The directed movement of L-tyrosine into the vacuole across the vacuolar membrane." [GOC:al]
is_a: GO:0032975 ! amino acid transmembrane import into vacuole
is_a: GO:0098655 ! cation transmembrane transport
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport
is_a: GO:1903808 ! L-tyrosine import into cell
created_by: tanyaberardini
creation_date: 2012-12-14T11:25:52Z

[Term]
id: GO:0090515
name: L-glutamate transmembrane import into vacuole
namespace: biological_process
def: "The directed movement of L-glutamate into the vacuole across the vacuolar membrane." [GOC:al]
is_a: GO:0089711 ! L-glutamate transmembrane transport
is_a: GO:0090454 ! glutamate transmembrane import into vacuole
is_a: GO:1903802 ! L-glutamate(1-) import into cell
created_by: tanyaberardini
creation_date: 2012-12-14T11:25:52Z

[Term]
id: GO:0090516
name: L-serine transmembrane import into vacuole
namespace: biological_process
def: "The directed movement of L-serine into the vacuole across the vacuolar membrane." [GOC:al]
is_a: GO:0034491 ! neutral amino acid transmembrane import into vacuole
is_a: GO:0098655 ! cation transmembrane transport
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport
is_a: GO:1903812 ! L-serine import into cell
created_by: tanyaberardini
creation_date: 2012-12-14T11:25:52Z

[Term]
id: GO:0090517
name: L-lysine transmembrane import into vacuole
namespace: biological_process
def: "The directed movement of L-lysine into the vacuole across the vacuolar membrane." [GOC:al]
is_a: GO:0061461 ! L-lysine import
is_a: GO:0090456 ! lysine transmembrane import into vacuole
is_a: GO:1903401 ! L-lysine transmembrane transport
created_by: tanyaberardini
creation_date: 2012-12-14T11:25:52Z

[Term]
id: GO:0090518
name: L-arginine transmembrane import into vacuole
namespace: biological_process
def: "The directed movement of L-arginine into the vacuole across the vacuolar membrane." [GOC:al]
is_a: GO:0043091 ! L-arginine import
is_a: GO:0090458 ! arginine transmembrane import into vacuole
is_a: GO:1903400 ! L-arginine transmembrane transport
created_by: tanyaberardini
creation_date: 2012-12-14T11:25:52Z

[Term]
id: GO:0090519
name: anoxia protection
namespace: biological_process
def: "Any process in which an organism or cell protects itself from anoxia, which may also result in resistance to repeated exposure to anoxia." [GOC:tb, PMID:19372430]
is_a: GO:0034059 ! response to anoxia
created_by: tanyaberardini
creation_date: 2012-12-21T15:37:37Z

[Term]
id: GO:0090520
name: sphingolipid mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals mediated by a sphingolipid." [PMID:9525917]
synonym: "ceramide 1-phosphate signaling pathway" NARROW [PMID:20870412]
synonym: "ceramide signaling pathway" NARROW [PMID:20870412]
synonym: "sphingolipid mediated signal transduction" EXACT [GOC:signaling]
synonym: "sphingolipid signaling pathway" RELATED []
synonym: "sphingolipid-mediated signaling pathway" EXACT [GOC:signaling]
synonym: "sphingosine signaling pathway" NARROW [PMID:20870412]
is_a: GO:0007165 ! signal transduction
created_by: tanyaberardini
creation_date: 2013-01-08T09:30:54Z

[Term]
id: GO:0090521
name: glomerular visceral epithelial cell migration
namespace: biological_process
def: "The orderly movement of a podocyte from one site to another, often during the development of a multicellular organism or multicellular structure. A podocyte is a specialized kidney epithelial cell." [GOC:pm, PMID:21402783]
synonym: "podocyte cell migration" RELATED [GOC:pm]
is_a: GO:0010631 ! epithelial cell migration
created_by: tanyaberardini
creation_date: 2013-01-08T11:08:57Z

[Term]
id: GO:0090522
name: vesicle tethering involved in exocytosis
namespace: biological_process
def: "The initial long-distance interaction between secretory vesicles and exocytotic sites on target membranes resulting in the capture and stabilization of vesicles prior to SNARE-mediated docking and fusion." [GOC:rn, PMID:10559876, PMID:17052174, PMID:17488620, PMID:22420621]
is_a: GO:0006903 ! vesicle targeting
relationship: part_of GO:0006887 ! exocytosis
created_by: tanyaberardini
creation_date: 2013-01-08T15:07:50Z

[Term]
id: GO:0090523
name: cytochrome-b5 reductase activity, acting on NADPH
namespace: molecular_function
def: "Catalysis of the reaction: NADPH + H+ + 2 ferricytochrome b(5) = NADP+ + 2 ferrocytochrome b(5)." [GOC:tb]
synonym: "cytochrome-b5 reductase activity" BROAD []
is_a: GO:0004128 ! cytochrome-b5 reductase activity, acting on NAD(P)H
created_by: tanyaberardini
creation_date: 2013-01-11T12:21:41Z

[Term]
id: GO:0090524
name: cytochrome-b5 reductase activity, acting on NADH
namespace: molecular_function
def: "Catalysis of the reaction: NADH + H+ + 2 ferricytochrome b(5) = NAD+ + 2 ferrocytochrome b(5)." [GOC:tb]
synonym: "cytochrome b5 reductase activity" BROAD []
is_a: GO:0004128 ! cytochrome-b5 reductase activity, acting on NAD(P)H
created_by: tanyaberardini
creation_date: 2013-01-11T12:21:50Z

[Term]
id: GO:0090525
name: regulation of glycolysis involved in cellular glucose homeostasis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glycolysis as an integral part of cellular glucose homeostasis." [GOC:tb]
is_a: GO:0006110 ! regulation of glycolytic process
intersection_of: GO:0006110 ! regulation of glycolytic process
intersection_of: part_of GO:0001678 ! cellular glucose homeostasis
relationship: part_of GO:0001678 ! cellular glucose homeostasis
created_by: tanyaberardini
creation_date: 2013-01-18T12:41:59Z

[Term]
id: GO:0090526
name: regulation of gluconeogenesis involved in cellular glucose homeostasis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gluconeogenesis as an integral part of cellular glucose homeostasis." [GOC:tb]
is_a: GO:0006111 ! regulation of gluconeogenesis
intersection_of: GO:0006111 ! regulation of gluconeogenesis
intersection_of: part_of GO:0001678 ! cellular glucose homeostasis
relationship: part_of GO:0001678 ! cellular glucose homeostasis
created_by: tanyaberardini
creation_date: 2013-01-18T12:47:43Z

[Term]
id: GO:0090527
name: actin filament reorganization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of actin filaments." [GOC:dph, GOC:tb]
is_a: GO:0007015 ! actin filament organization
relationship: part_of GO:0031532 ! actin cytoskeleton reorganization
created_by: tanyaberardini
creation_date: 2013-01-23T10:27:44Z

[Term]
id: GO:0090528
name: smooth septate junction assembly
namespace: biological_process
def: "The assembly of a smooth septate junction, a septate junction that lacks the regular arrays of electron-dense septae found in pleated septate junctions." [PMID:22854041]
is_a: GO:0019991 ! septate junction assembly
created_by: tanyaberardini
creation_date: 2013-02-05T14:47:40Z

[Term]
id: GO:0090529
name: cell septum assembly
namespace: biological_process
alt_id: GO:0090530
def: "The assembly and arrangement of a cellular component that is composed of peptidoglycan and often chitin in addition to other materials and usually forms perpendicular to the long axis of a cell or hypha. It grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells." [GOC:mtg_cell_cycle]
synonym: "cell septum assembly involved in cell cycle cytokinesis" EXACT []
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0032506 ! cytokinetic process
relationship: part_of GO:0000910 ! cytokinesis
created_by: tanyaberardini
creation_date: 2013-02-06T10:26:38Z

[Term]
id: GO:0090531
name: L-ascorbic acid biosynthetic process via GDP-alpha-D-mannose
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-ascorbic acid via the intermediate GDP-alpha-D-mannose." [BioCyc:PWY-882, GOC:yaf, PMID:11153268, UniPathway:UPA00990]
synonym: "L-ascorbic acid biosynthesis via GDP-alpha-D-mannose" RELATED []
synonym: "Smirnoff-Wheeler's pathway" RELATED [UniPathway:UPA00990]
is_a: GO:0019853 ! L-ascorbic acid biosynthetic process
created_by: tanyaberardini
creation_date: 2013-02-06T15:31:01Z

[Term]
id: GO:0090532
name: L-ascorbic acid biosynthetic process via UDP-alpha-D-glucuronate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-ascorbic acid via the intermediate UDP-alpha-D-glucuronate." [BioCyc:PWY3DJ-35471, GOC:yaf, PMID:11153268, UniPathway:UPA00991]
comment: This pathway occurs in most vertebrates, although not in guinea pigs and primates, including humans.
synonym: "L-ascorbic acid biosynthesis via UDP-alpha-D-glucuronate" RELATED []
is_a: GO:0019853 ! L-ascorbic acid biosynthetic process
created_by: tanyaberardini
creation_date: 2013-02-06T15:31:01Z

[Term]
id: GO:0090533
name: cation-transporting ATPase complex
namespace: cellular_component
def: "Protein complex that carries out the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in)." [GOC:BHF]
is_a: GO:0098533 ! ATPase dependent transmembrane transport complex
created_by: tanyaberardini
creation_date: 2013-02-07T15:50:28Z

[Term]
id: GO:0090534
name: calcium ion-transporting ATPase complex
namespace: cellular_component
def: "Protein complex that carries out the reaction: ATP + H2O + Ca2+(out) = ADP + phosphate + Ca2+(in)." [GOC:BHF]
is_a: GO:0090533 ! cation-transporting ATPase complex
created_by: tanyaberardini
creation_date: 2013-02-07T15:52:58Z

[Term]
id: GO:0090535
name: WICH complex
namespace: cellular_component
def: "An ISWI complex that contains an ATPase subunit of the ISWI family (specifically SNF2H in mammals, which contain two ISWI homologs) and WSTF (Williams Syndrome Transcription Factor). WICH plays roles in regulation of RNAP I and III transcription and in DNA replication and repair." [GOC:krc, PMID:15284901, PMID:16568949, PMID:21810179]
is_a: GO:0031010 ! ISWI-type complex
created_by: tanyaberardini
creation_date: 2013-02-11T14:07:14Z

[Term]
id: GO:0090536
name: NoRC complex
namespace: cellular_component
def: "An ISWI complex that contains an ATPase subunit of the ISWI family (specifically SNF2H in mammals, which contain two ISWI homologs) and a Tip5 homolog. In mammals, NoRC is involved in regulation of transcription from RNAP I and RNA polymerase III promoters." [GOC:krc]
is_a: GO:0031010 ! ISWI-type complex
created_by: tanyaberardini
creation_date: 2013-02-11T14:07:14Z

[Term]
id: GO:0090537
name: CERF complex
namespace: cellular_component
def: "An ISWI complex that contains an ATPase subunit of the ISWI family (specifically SNF2L in mammals, which contain two ISWI homologs) and a CECR2 homolog. In mammals, CERF is involved in regulation of transcription from RNA polymerase II promoters." [GOC:krc]
is_a: GO:0031010 ! ISWI-type complex
created_by: tanyaberardini
creation_date: 2013-02-11T14:07:14Z

[Term]
id: GO:0090538
name: peptide pheromone secretion
namespace: biological_process
def: "The regulated release of a peptide pheromone from a cell." [GOC:al, GOC:tb, GOC:vw]
is_a: GO:0000770 ! peptide pheromone export
is_a: GO:0030072 ! peptide hormone secretion
created_by: tanyaberardini
creation_date: 2013-02-11T15:38:29Z

[Term]
id: GO:0090539
name: peptide pheromone export by transmembrane transport
namespace: biological_process
def: "The directed movement of a peptide pheromone across a membrane and out of a cell." [GOC:al, GOC:tb, GOC:vw]
synonym: "peptide pheromone export by membrane transport" EXACT []
is_a: GO:0000770 ! peptide pheromone export
is_a: GO:0055085 ! transmembrane transport
created_by: tanyaberardini
creation_date: 2013-02-11T15:44:51Z

[Term]
id: GO:0090540
name: bacterial cellulose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, as it occurs in certain types of bacteria, mainly Acetobacter, Sarcina ventriculi and Agrobacteria." [DOI:10.1016/S0268-005X(87)80024-3, DOI:10.1023/A\:1009272904582, GOC:tb, GOC:yaf, UniPathway:UPA00694]
synonym: "bacterial cellulose biosynthesis" EXACT [GOC:yaf]
is_a: GO:0030244 ! cellulose biosynthetic process
created_by: tanyaberardini
creation_date: 2013-02-11T16:32:44Z

[Term]
id: GO:0090541
name: MIT domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the MIT domain of a protein. The MIT domain is found in vacuolar sorting proteins, spastin (probable ATPase involved in the assembly or function of nuclear protein complexes), and a sorting nexin, which may play a role in intracellular trafficking." [GOC:pm, InterPro:IPR007330]
is_a: GO:0019904 ! protein domain specific binding
created_by: tanyaberardini
creation_date: 2013-02-14T17:11:29Z

[Term]
id: GO:0090542
name: ELYC domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the ELYC domain of a protein. The ELYC domain is an approximately 150 amino acid sequence which contains a highly conserved tetrapeptide sequence, ELYC." [GOC:pm, PMID:18032582, PMID:19525971]
is_a: GO:0019904 ! protein domain specific binding
created_by: tanyaberardini
creation_date: 2013-02-14T17:11:29Z

[Term]
id: GO:0090543
name: Flemming body
namespace: cellular_component
def: "A cell part that is the central region of the midbody characterized by a gap in alpha-tubulin staining. It is a dense structure of antiparallel microtubules from the central spindle in the middle of the intercellular bridge." [GOC:pm, PMID:18641129, PMID:22522702]
is_a: GO:0044464 ! cell part
relationship: part_of GO:0030496 ! midbody
created_by: tanyaberardini
creation_date: 2013-02-14T17:24:43Z

[Term]
id: GO:0090544
name: BAF-type complex
namespace: cellular_component
def: "A SWI/SNF-type complex that contains a subunit from the BAF (Brahma-Associated Factor) family." [GOC:krc, GOC:tb]
is_a: GO:0070603 ! SWI/SNF superfamily-type complex
created_by: tanyaberardini
creation_date: 2013-02-15T12:11:14Z

[Term]
id: GO:0090545
name: CHD-type complex
namespace: cellular_component
def: "A SWI/SNF-type complex that contains a subunit from the CHD(Chromodomain helicase DNA-binding) family. The CHD family is characterized by two signature sequence motifs: tandem chromodomains located in the N-terminal region, and the SNF2-like ATPase domain located in the central region of the protein structure." [GOC:krc, GOC:tb, PMID:17350655]
is_a: GO:0070603 ! SWI/SNF superfamily-type complex
created_by: tanyaberardini
creation_date: 2013-02-15T12:11:57Z

[Term]
id: GO:0090546
name: chlorophyll fluorescence
namespace: biological_process
def: "The process by which excess light energy absorbed by chlorophyll and not used to drive photosynthesis is re-emitted as light." [PMID:10938857]
is_a: GO:1990066 ! energy quenching
created_by: tanyaberardini
creation_date: 2013-03-27T14:23:27Z

[Term]
id: GO:0090547
name: response to low humidity
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of low humidity stimulus, reduced moisture in the atmosphere." [GOC:tb]
is_a: GO:0009270 ! response to humidity
created_by: tanyaberardini
creation_date: 2013-04-17T13:46:28Z

[Term]
id: GO:0090548
name: response to nitrate starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nitrate." [GOC:tair_curators]
is_a: GO:0042594 ! response to starvation
created_by: tanyaberardini
creation_date: 2013-04-22T13:57:16Z

[Term]
id: GO:0090549
name: response to carbon starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of a carbon source." [GOC:tair_curators, PMID:18245858]
is_a: GO:0042594 ! response to starvation
created_by: tanyaberardini
creation_date: 2013-04-22T13:57:16Z

[Term]
id: GO:0090550
name: response to molybdenum starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of molybdenum." [GOC:tair_curators]
is_a: GO:0042594 ! response to starvation
created_by: tanyaberardini
creation_date: 2013-04-22T13:57:16Z

[Term]
id: GO:0090551
name: response to manganese starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of manganese." [GOC:tair_curators]
is_a: GO:0042594 ! response to starvation
created_by: tanyaberardini
creation_date: 2013-04-22T13:57:16Z

[Term]
id: GO:0090552
name: unicellular trichome apex
namespace: cellular_component
def: "A cell projection part that is the apical most portion of a unicellular trichome." [GOC:PO_curators, PO:0025537]
is_a: GO:0044463 ! cell projection part
created_by: tanyaberardini
creation_date: 2013-04-25T11:56:56Z

[Term]
id: GO:0090553
name: unicellular trichome tip
namespace: cellular_component
def: "A cell projection part that is the apical most portion of a unicellular trichome apex." [GOC:PO_curators]
is_a: GO:0044463 ! cell projection part
relationship: part_of GO:0090552 ! unicellular trichome apex
created_by: tanyaberardini
creation_date: 2013-04-25T11:56:56Z

[Term]
id: GO:0090554
name: phosphatidylcholine-translocating ATPase activity
namespace: molecular_function
def: "Catalysis of the movement of phosphatidylcholine from one membrane bilayer leaflet to the other, driven by the hydrolysis of ATP." [CHEBI:64612, GOC:ab, PMID:16452632, RHEA:38584]
synonym: "phosphatidylcholine flippase activity" EXACT []
is_a: GO:0004012 ! phospholipid-translocating ATPase activity
is_a: GO:0008525 ! phosphatidylcholine transporter activity
created_by: tanyaberardini
creation_date: 2013-10-24T16:07:20Z

[Term]
id: GO:0090555
name: phosphatidylethanolamine-translocating ATPase activity
namespace: molecular_function
def: "Catalysis of the movement of phosphatidylethanolamine from one membrane bilayer leaflet to the other, driven by the hydrolysis of ATP." [CHEBI:64612, GOC:ab, PMID:16452632, RHEA:36440]
synonym: "phosphatidylethanolamine flippase activity" EXACT []
is_a: GO:0004012 ! phospholipid-translocating ATPase activity
created_by: tanyaberardini
creation_date: 2013-10-24T16:07:20Z

[Term]
id: GO:0090556
name: phosphatidylserine-translocating ATPase activity
namespace: molecular_function
def: "Catalysis of the movement of phosphatidylserine from one membrane bilayer leaflet to the other, driven by the hydrolysis of ATP." [CHEBI:57262, GOC:ab, PMID:16452632, PMID:20224745, RHEA:38568]
synonym: "phosphatidylserine flippase activity" EXACT []
is_a: GO:0004012 ! phospholipid-translocating ATPase activity
created_by: tanyaberardini
creation_date: 2013-10-24T16:07:20Z

[Term]
id: GO:0090557
name: establishment of endothelial intestinal barrier
namespace: biological_process
def: "The establishment of a barrier between endothelial cell layers of the intestine to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition." [GOC:krc, PMID:22155109]
is_a: GO:0061028 ! establishment of endothelial barrier
created_by: tanyaberardini
creation_date: 2013-10-29T15:08:27Z

[Term]
id: GO:0090558
name: plant epidermis development
namespace: biological_process
def: "The process whose specific outcome is the progression of the plant epidermis over time, from its formation to the mature structure." [GOC:tb]
is_a: GO:0009888 ! tissue development
created_by: tanyaberardini
creation_date: 2014-02-27T15:17:37Z

[Term]
id: GO:0090559
name: regulation of membrane permeability
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by a membrane." [GOC:kmv, PMID:22677064]
is_a: GO:0065008 ! regulation of biological quality
created_by: tanyaberardini
creation_date: 2014-03-27T13:48:35Z

[Term]
id: GO:0090560
name: 2-(3-amino-3-carboxypropyl)histidine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction S-adenosyl-L-methionine + L-histidine-[translation elongation factor 2] = S-methyl-5-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-[translation elongation factor 2]." [BRENDA:2.5.1.108, GOC:pde, PMID:15485916]
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups
created_by: tanyaberardini
creation_date: 2014-03-27T14:58:50Z

[Term]
id: GO:0090561
name: nuclear migration during mitotic telophase
namespace: biological_process
def: "The dynein-driven microtubule based nuclear migration, whereby daughter nuclei are positioned away from the cell division site prior to cytokinesis." [GOC:vw, PMID:23087209]
is_a: GO:0030473 ! nuclear migration along microtubule
created_by: tanyaberardini
creation_date: 2014-03-27T15:17:10Z

[Term]
id: GO:0090562
name: protein-N(PI)-phosphohistidine-N,N'-diacetylchitobiose phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N,N'-diacetylchitobiose(out) = protein histidine + N,N'-diacetylchitobiose phosphate(in)." [GOC:am, PMID:10913119]
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
created_by: tanyaberardini
creation_date: 2014-04-08T14:55:02Z

[Term]
id: GO:0090563
name: protein-phosphocysteine-sugar phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + sugar(out) = protein cysteine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:am]
is_a: GO:0015144 ! carbohydrate transmembrane transporter activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0022804 ! active transmembrane transporter activity
created_by: tanyaberardini
creation_date: 2014-04-08T14:58:00Z

[Term]
id: GO:0090564
name: protein-phosphocysteine-glucose phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + glucose(out) = protein cysteine + glucose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:am]
is_a: GO:0090563 ! protein-phosphocysteine-sugar phosphotransferase activity
created_by: tanyaberardini
creation_date: 2014-04-08T15:03:08Z

[Term]
id: GO:0090565
name: protein-phosphocysteine-mannitol phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + mannitol(out) = protein cysteine + mannitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:am]
is_a: GO:0090563 ! protein-phosphocysteine-sugar phosphotransferase activity
created_by: tanyaberardini
creation_date: 2014-04-08T15:03:08Z

[Term]
id: GO:0090566
name: protein-phosphocysteine-N,N'-diacetylchitobiose phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + N,N'-diacetylchitobiose(out) = protein cysteine + N,N'-diacetylchitobiose phosphate(in)." [GOC:am, PMID:10913119]
is_a: GO:0090563 ! protein-phosphocysteine-sugar phosphotransferase activity
created_by: tanyaberardini
creation_date: 2014-04-08T15:08:43Z

[Term]
id: GO:0090567
name: reproductive shoot system development
namespace: biological_process
def: "The process whose specific outcome is the progression of a reproductive shoot system over time, from its formation to the mature structure." [GOC:pj]
is_a: GO:0009791 ! post-embryonic development
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0048367 ! shoot system development
is_a: GO:0048608 ! reproductive structure development
created_by: tanyaberardini
creation_date: 2014-04-25T15:42:03Z

[Term]
id: GO:0090568
name: nuclear transcriptional repressor complex
namespace: cellular_component
def: "A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription." [GOC:tb]
is_a: GO:0017053 ! transcriptional repressor complex
is_a: GO:0044451 ! nucleoplasm part
intersection_of: GO:0017053 ! transcriptional repressor complex
intersection_of: part_of GO:0005634 ! nucleus
relationship: part_of GO:0005634 ! nucleus
created_by: tanyaberardini
creation_date: 2014-05-09T13:23:51Z

[Term]
id: GO:0090569
name: cytoplasmic transcriptional repressor complex
namespace: cellular_component
def: "A protein complex, located in the cytoplasm, that possesses activity that prevents or downregulates transcription." [GOC:tb]
is_a: GO:0017053 ! transcriptional repressor complex
is_a: GO:0044444 ! cytoplasmic part
intersection_of: GO:0017053 ! transcriptional repressor complex
intersection_of: part_of GO:0005737 ! cytoplasm
relationship: part_of GO:0005737 ! cytoplasm
created_by: tanyaberardini
creation_date: 2014-05-09T13:23:51Z

[Term]
id: GO:0090570
name: RNA polymerase I transcription repressor complex
namespace: cellular_component
def: "A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase I promoter." [GOC:tb]
is_a: GO:0090568 ! nuclear transcriptional repressor complex
created_by: tanyaberardini
creation_date: 2014-05-09T13:26:16Z

[Term]
id: GO:0090571
name: RNA polymerase II transcription repressor complex
namespace: cellular_component
def: "A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase II promoter." [GOC:tb]
is_a: GO:0090568 ! nuclear transcriptional repressor complex
created_by: tanyaberardini
creation_date: 2014-05-09T13:26:16Z

[Term]
id: GO:0090572
name: RNA polymerase III transcription repressor complex
namespace: cellular_component
def: "A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase III promoter." [GOC:tb]
is_a: GO:0090568 ! nuclear transcriptional repressor complex
created_by: tanyaberardini
creation_date: 2014-05-09T13:26:16Z

[Term]
id: GO:0090573
name: RNA polymerase IV transcription repressor complex
namespace: cellular_component
def: "A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase IV promoter." [GOC:tb]
is_a: GO:0090568 ! nuclear transcriptional repressor complex
created_by: tanyaberardini
creation_date: 2014-05-09T13:26:16Z

[Term]
id: GO:0090574
name: RNA polymerase V transcription repressor complex
namespace: cellular_component
def: "A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase V promoter." [GOC:tb]
is_a: GO:0090568 ! nuclear transcriptional repressor complex
created_by: tanyaberardini
creation_date: 2014-05-09T13:26:16Z

[Term]
id: GO:0090575
name: RNA polymerase II transcription factor complex
namespace: cellular_component
def: "A transcription factor complex that acts at promoters of genes transcribed by RNA polymerase II." [GOC:tb]
is_a: GO:0044798 ! nuclear transcription factor complex
created_by: tanyaberardini
creation_date: 2014-05-09T14:04:37Z

[Term]
id: GO:0090576
name: RNA polymerase III transcription factor complex
namespace: cellular_component
def: "A transcription factor complex that acts at promoters of genes transcribed by RNA polymerase III." [GOC:tb]
is_a: GO:0044798 ! nuclear transcription factor complex
created_by: tanyaberardini
creation_date: 2014-05-09T14:04:37Z

[Term]
id: GO:0090577
name: RNA polymerase IV transcription factor complex
namespace: cellular_component
def: "A transcription factor complex that acts at promoters of genes transcribed by RNA polymerase IV." [GOC:tb]
is_a: GO:0044798 ! nuclear transcription factor complex
created_by: tanyaberardini
creation_date: 2014-05-09T14:04:37Z

[Term]
id: GO:0090578
name: RNA polymerase V transcription factor complex
namespace: cellular_component
def: "A transcription factor complex that acts at promoters of genes transcribed by RNA polymerase V." [GOC:tb]
is_a: GO:0044798 ! nuclear transcription factor complex
created_by: tanyaberardini
creation_date: 2014-05-09T14:04:37Z

[Term]
id: GO:0090579
name: dsDNA loop formation
namespace: biological_process
def: "The formation and maintenance of DNA loops that juxtapose separated regions on the same dsDNA molecule." [GOC:jh, PMID:15950878]
is_a: GO:0051276 ! chromosome organization
created_by: tanyaberardini
creation_date: 2014-05-12T14:45:58Z

[Term]
id: GO:0090580
name: phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands
namespace: molecular_function
def: "Catalysis of the hydrolytic removal of phosphoglycolate from the 3'-terminus of a 3'-phosphoglycolate-terminated oligonucleotides." [GOC:pde, GOC:rb, PMID:11238902]
is_a: GO:0008081 ! phosphoric diester hydrolase activity
created_by: tanyaberardini
creation_date: 2014-05-14T15:52:41Z

[Term]
id: GO:0090581
name: protein-phosphocysteine-mannosylglycerate-phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + mannosylglycerate(out) = protein cysteine + mannosylglycerate phosphate(in)." [PMID:14645248]
is_a: GO:0090563 ! protein-phosphocysteine-sugar phosphotransferase activity
created_by: tanyaberardini
creation_date: 2014-06-04T16:22:31Z

[Term]
id: GO:0090582
name: protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + D-fructose(out) = protein cysteine + D-fructose-1-phosphate(in)." [PMID:8626640]
is_a: GO:0090563 ! protein-phosphocysteine-sugar phosphotransferase activity
created_by: tanyaberardini
creation_date: 2014-06-04T16:22:31Z

[Term]
id: GO:0090583
name: protein-phosphocysteine-D-sorbitol-phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + D-sorbitol(out) = protein cysteine + D-sorbitol-1-phosphate(in)." [PMID:8875915]
is_a: GO:0090563 ! protein-phosphocysteine-sugar phosphotransferase activity
created_by: tanyaberardini
creation_date: 2014-06-04T16:22:31Z

[Term]
id: GO:0090584
name: protein-phosphocysteine-galactitol-phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + galactitol(out) = protein cysteine + galactitol-6-phosphate(in)." [PMID:8955298]
is_a: GO:0090563 ! protein-phosphocysteine-sugar phosphotransferase activity
created_by: tanyaberardini
creation_date: 2014-06-04T16:22:31Z

[Term]
id: GO:0090585
name: protein-phosphocysteine-L-ascorbate-phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + L-ascorbate(out) = protein cysteine + L-ascorbate-6-phosphate(in)." [PMID:15153772]
is_a: GO:0090563 ! protein-phosphocysteine-sugar phosphotransferase activity
created_by: tanyaberardini
creation_date: 2014-06-04T16:22:31Z

[Term]
id: GO:0090586
name: protein-phosphocysteine-N-acetylglucosamine phosphotransferase system transporter activity
namespace: molecular_function
def: ": Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + N-acetylglucosamine (out) = protein cysteine + N-acetylglucosamine-6-phosphate (in)." [PMID:8246840]
is_a: GO:0090563 ! protein-phosphocysteine-sugar phosphotransferase activity
created_by: tanyaberardini
creation_date: 2014-06-04T16:22:31Z

[Term]
id: GO:0090587
name: protein-phosphocysteine-glucosamine phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + glucosamine (out) = protein cysteine + glucosamine-6-phosphate (in)." [PMID:8246840]
is_a: GO:0090563 ! protein-phosphocysteine-sugar phosphotransferase activity
created_by: tanyaberardini
creation_date: 2014-06-04T16:22:31Z

[Term]
id: GO:0090588
name: protein-phosphocysteine-N-acetylmuramate phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + N-acetylmuramate (out) = protein cysteine + N-acetylmuramate-6-phosphate (in)." [PMID:15060041]
is_a: GO:0090563 ! protein-phosphocysteine-sugar phosphotransferase activity
created_by: tanyaberardini
creation_date: 2014-06-04T16:22:31Z

[Term]
id: GO:0090589
name: protein-phosphocysteine-trehalose phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + trehalose (out) = protein cysteine + trehalose-6-phosphate (in)." [PMID:7608078]
is_a: GO:0090563 ! protein-phosphocysteine-sugar phosphotransferase activity
created_by: tanyaberardini
creation_date: 2014-06-04T16:22:31Z

[Term]
id: GO:0090590
name: protein-N(PI)-phosphohistidine-D-glucosamine phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + D-glucosamine(out) = protein histidine + glucosamine-6-phosphate(in)." [PMID:8246840]
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
created_by: tanyaberardini
creation_date: 2014-06-04T16:33:01Z

[Term]
id: GO:0090591
name: protein-N(PI)-phosphohistidine-N-acetyl-mannosamine phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetyl-mannosamine(out) = protein histidine +N-acetyl- mannosamine-6-phosphate(in)." [PMID:9864311]
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
created_by: tanyaberardini
creation_date: 2014-06-04T16:33:01Z

[Term]
id: GO:0090592
name: DNA synthesis involved in DNA replication
namespace: biological_process
def: "Synthesis of DNA that is a part of the process of duplicating one or more molecules of DNA." [GOC:vw]
is_a: GO:0071897 ! DNA biosynthetic process
intersection_of: GO:0071897 ! DNA biosynthetic process
intersection_of: part_of GO:0006260 ! DNA replication
relationship: part_of GO:0006260 ! DNA replication
created_by: tanyaberardini
creation_date: 2014-06-06T13:54:36Z

[Term]
id: GO:0090593
name: peptidyl-histidine autophosphorylation
namespace: biological_process
def: "The phosphorylation by a protein of one or more of its own histidine residues, or a histidine residue on an identical protein." [PMID:15947782, PMID:8962061]
is_a: GO:0046777 ! protein autophosphorylation
created_by: tanyaberardini
creation_date: 2014-06-06T14:19:46Z

[Term]
id: GO:0090594
name: inflammatory response to wounding
namespace: biological_process
def: "The immediate defensive reaction by vertebrate tissue to injury caused by chemical or physical agents." [GOC:add]
is_a: GO:0006954 ! inflammatory response
is_a: GO:0009611 ! response to wounding
created_by: tanyaberardini
creation_date: 2014-08-12T12:13:53Z

[Term]
id: GO:0090595
name: acetyl-CoA:L-lysine N6-acetyltransferase
namespace: molecular_function
def: "Catalysis of the reaction: L-lysine + acetyl-CoA = N6-acetyl-L-lysine + CoA + H(+)." [MetaCyc:LYSACET-RXN]
xref: EC:2.3.1.-
is_a: GO:0008080 ! N-acetyltransferase activity
created_by: tanyaberardini
creation_date: 2014-08-21T17:19:06Z

[Term]
id: GO:0090596
name: sensory organ morphogenesis
namespace: biological_process
def: "Morphogenesis of a sensory organ. A sensory organ is defined as a tissue or set of tissues that work together to receive and transmit signals from external or internal stimuli. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:kmv, ISBN:978-0199210893]
is_a: GO:0009887 ! organ morphogenesis
relationship: part_of GO:0007423 ! sensory organ development
created_by: tanyaberardini
creation_date: 2014-08-22T13:23:20Z

[Term]
id: GO:0090597
name: nematode male tail mating organ morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the nematode male tail mating organ are generated and organized. The male tail is a sensory organ required for mating and, in C. elegans, consists of ray sensilla, an acellular cuticular fan, a sensory hook, and protracting, copulatory spicules." [GOC:kmv, PMID:1782863, PMID:18050419, PMID:7409314]
is_a: GO:0048808 ! male genitalia morphogenesis
is_a: GO:0090596 ! sensory organ morphogenesis
created_by: tanyaberardini
creation_date: 2014-08-22T13:25:22Z

[Term]
id: GO:0090598
name: male anatomical structure morphogenesis
namespace: biological_process
def: "The processes by which anatomical structures that are only present in the male organism are generated and organized." [GOC:kmv, GOC:tb]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0046661 ! male sex differentiation
created_by: tanyaberardini
creation_date: 2014-08-22T13:29:45Z

[Term]
id: GO:0090599
name: alpha-glucosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal, non-reducing alpha-linked alpha-D-glucose residue with release of alpha-D-glucose." [GOC:tb]
is_a: GO:0015926 ! glucosidase activity
created_by: tanyaberardini
creation_date: 2014-08-22T14:33:31Z

[Term]
id: GO:0090600
name: alpha-1,3-glucosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal, non-reducing alpha-(1->3)-linked alpha-D-glucose residues with release of alpha-D-glucose." [GOC:sd, GOC:tb]
is_a: GO:0090599 ! alpha-glucosidase activity
created_by: tanyaberardini
creation_date: 2014-08-22T15:00:45Z

[Term]
id: GO:0090601
name: enucleation
namespace: biological_process
def: "The process in which nucleated precursor cells lose their nucleus." [GOC:tb]
is_a: GO:0022411 ! cellular component disassembly
created_by: tanyaberardini
creation_date: 2014-09-05T16:25:16Z

[Term]
id: GO:0090602
name: sieve element enucleation
namespace: biological_process
def: "The process in which nucleated precursor cells lose their nucleus as part of sieve element differentiation. The nuclear contents are released and degraded in the cytoplasm at the same time as other organelles are rearranged and the cytosol is degraded." [GOC:tb, PMID:25081480]
is_a: GO:0090601 ! enucleation
relationship: part_of GO:0090603 ! sieve element differentiation
created_by: tanyaberardini
creation_date: 2014-09-05T16:25:16Z

[Term]
id: GO:0090603
name: sieve element differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a sieve element." [GOC:tb]
is_a: GO:0030154 ! cell differentiation
created_by: tanyaberardini
creation_date: 2014-09-05T16:38:20Z

[Term]
id: GO:0090604
name: surface biofilm formation
namespace: biological_process
def: "A process in which planktonically growing microorganisms grow at the surface of a liquid-air interface and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription." [GOC:di, GOC:tb]
is_a: GO:0042710 ! biofilm formation
created_by: tanyaberardini
creation_date: 2014-09-16T14:38:45Z

[Term]
id: GO:0090605
name: submerged biofilm formation
namespace: biological_process
def: "A process in which planktonically growing microorganisms aggregate and grow on solid substrates under the flow of a liquid and produce extracellular polymers that facilitate attachment and matrix formation, resulting in a change in the organisms' growth rate and gene transcription." [GOC:di, GOC:tb]
synonym: "solid substrate biofilm formation" RELATED []
is_a: GO:0042710 ! biofilm formation
created_by: tanyaberardini
creation_date: 2014-09-16T14:44:46Z

[Term]
id: GO:0090606
name: single-species surface biofilm formation
namespace: biological_process
def: "A process in which planktonically growing microorganisms of the same species grow at the surface of a liquid-air interface and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription." [GOC:di, GOC:tb]
is_a: GO:0044010 ! single-species biofilm formation
is_a: GO:0090604 ! surface biofilm formation
created_by: tanyaberardini
creation_date: 2014-09-16T14:47:11Z

[Term]
id: GO:0090607
name: multi-species surface biofilm formation
namespace: biological_process
def: "A process in which planktonically growing microorganisms of different species grow at the surface of a liquid-air interface and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription." [GOC:di, GOC:tb]
is_a: GO:0044399 ! multi-species biofilm formation
is_a: GO:0090604 ! surface biofilm formation
created_by: tanyaberardini
creation_date: 2014-09-16T14:49:35Z

[Term]
id: GO:0090608
name: multi-species submerged biofilm formation
namespace: biological_process
def: "A process in which planktonically growing microorganisms of different species aggregate and grow on solid substrates under the flow of a liquid and produce extracellular polymers that facilitate attachment and matrix formation, resulting in a change in the organisms' growth rate and gene transcription." [GOC:di, GOC:tb]
is_a: GO:0044399 ! multi-species biofilm formation
is_a: GO:0090605 ! submerged biofilm formation
created_by: tanyaberardini
creation_date: 2014-09-16T14:49:35Z

[Term]
id: GO:0090609
name: single-species submerged biofilm formation
namespace: biological_process
def: "A process in which planktonically growing microorganisms of the same species aggregate and grow on solid substrates under the flow of a liquid and produce extracellular polymers that facilitate attachment and matrix formation, resulting in a change in the organisms' growth rate and gene transcription." [GOC:di, GOC:tb]
is_a: GO:0044010 ! single-species biofilm formation
is_a: GO:0090605 ! submerged biofilm formation
created_by: tanyaberardini
creation_date: 2014-09-16T14:55:15Z

[Term]
id: GO:0090610
name: bundle sheath cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a bundle sheath cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:tb, PMID:24517883]
is_a: GO:0001708 ! cell fate specification
created_by: tanyaberardini
creation_date: 2014-09-26T13:17:05Z

[Term]
id: GO:0090611
name: ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide, via the multivesicular body (MVB) sorting pathway; proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation.  This process is independent of ubiquitination." [PMID:22547407]
is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process
relationship: has_part GO:0007039 ! protein catabolic process in the vacuole
relationship: has_part GO:0071985 ! multivesicular body sorting pathway
created_by: tanyaberardini
creation_date: 2014-10-23T15:27:12Z

[Term]
id: GO:0090612
name: cAMP deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyclic adenosine monophosphate + H2O = cyclic inosine monophosphate + NH3." [PMID:24074367]
synonym: "cyclic adenosine monophosphate deaminase activity" EXACT []
is_a: GO:0019239 ! deaminase activity
created_by: tanyaberardini
creation_date: 2014-10-23T15:46:42Z

[Term]
id: GO:0090613
name: 5'-deoxyadenosine deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5'deoxyadenosine + H2O = 5'deoxyinosine + NH3." [PMID:23968233]
is_a: GO:0019239 ! deaminase activity
created_by: tanyaberardini
creation_date: 2014-10-23T15:59:38Z

[Term]
id: GO:0090614
name: 5'-methylthioadenosine deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5'methyl thioadenosine + H2O = 5'methyl thioinosine + NH3." [PMID:23968233]
is_a: GO:0019239 ! deaminase activity
created_by: tanyaberardini
creation_date: 2014-10-23T15:59:38Z

[Term]
id: GO:0090615
name: mitochondrial mRNA processing
namespace: biological_process
def: "Steps involved in processing precursor RNAs arising from transcription of operons in the mitochondrial genome into mature mRNAs." [GOC:tb, PMID:25181358]
is_a: GO:0000963 ! mitochondrial RNA processing
is_a: GO:0006397 ! mRNA processing
intersection_of: GO:0006397 ! mRNA processing
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion
created_by: tanyaberardini
creation_date: 2014-10-24T12:43:27Z

[Term]
id: GO:0090616
name: mitochondrial mRNA 3'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 3' end of an mRNA molecule that derives from the mitochondrial genome." [GOC:tb, PMID:25181358]
is_a: GO:0000965 ! mitochondrial RNA 3'-end processing
is_a: GO:0031124 ! mRNA 3'-end processing
is_a: GO:0090615 ! mitochondrial mRNA processing
intersection_of: GO:0031124 ! mRNA 3'-end processing
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion
created_by: tanyaberardini
creation_date: 2014-10-24T12:45:08Z

[Term]
id: GO:0090617
name: mitochondrial mRNA 5'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 5' end of an mRNA molecule that derives from the mitochondrial genome." [GOC:tb, PMID:25181358]
is_a: GO:0090615 ! mitochondrial mRNA processing
created_by: tanyaberardini
creation_date: 2014-10-24T12:45:08Z

[Term]
id: GO:0090618
name: DNA clamp unloading
namespace: biological_process
def: "The process of removing the PCNA complex from DNA when Okazaki fragments are completed or the replication fork terminates." [GOC:rb, PMID:23499004]
synonym: "PCNA unloading" RELATED [GOC:rb, PMID:23499004]
is_a: GO:0044763 ! single-organism cellular process
created_by: tanyaberardini
creation_date: 2014-10-29T12:57:05Z

[Term]
id: GO:0090619
name: meiotic spindle pole
namespace: cellular_component
def: "Either of the ends of a meiotic spindle, a spindle that forms as part of meiosis, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:ha, PMID:18250200]
is_a: GO:0000922 ! spindle pole
relationship: part_of GO:0072687 ! meiotic spindle
created_by: tanyaberardini
creation_date: 2014-12-16T16:38:34Z

[Term]
id: GO:0090620
name: APC-Cdc20 complex
namespace: cellular_component
def: "An anaphase promoting complex bound to the \"fizzy family\" APC activator Cdc20/Slp1 which regulates the metaphase anaphase transition by activating the APC/C to target the anaphase inhibitor securin and promotes sister chromatid separation." [GOC:vw, PMID:10921876]
synonym: "APC-fizzy complex" EXACT [GOC:vw]
synonym: "APC-Slp1 complex" EXACT [GOC:vw]
synonym: "mitotic anaphase promotic complex" RELATED [GOC:vw]
is_a: GO:0005680 ! anaphase-promoting complex
created_by: tanyaberardini
creation_date: 2014-12-17T17:01:38Z

[Term]
id: GO:0090621
name: APC-fizzy-related complex
namespace: cellular_component
def: "An anaphase promoting complex bound to the \"fizzy-related family\" APC activator FZR1/Cdh1/Srw1 that regulates mitotic exit by activating the APC/C to target mitotic cyclins for destruction during anaphase and telophase. Is also active during G1." [GOC:vw, PMID:10921876]
synonym: "APC-Hct1/Cdh1 complex" EXACT [GOC:vw]
synonym: "APC-Srw1 complex" EXACT [GOC:vw]
is_a: GO:0005680 ! anaphase-promoting complex
created_by: tanyaberardini
creation_date: 2014-12-17T17:01:38Z

[Term]
id: GO:0090622
name: APC-fizzy related complex activity
namespace: molecular_function
def: "A ubiquitin-protein ligase activity that increases the rate or extent of the mitotic exit." [GOC:vw, PMID:10921876]
is_a: GO:0061630 ! ubiquitin protein ligase activity
relationship: part_of GO:0031536 ! positive regulation of exit from mitosis
created_by: tanyaberardini
creation_date: 2015-01-21T14:23:07Z

[Term]
id: GO:0090623
name: activation of APC-fizzy related complex activity
namespace: biological_process
def: "Any process that initiates the ubiquitin ligase activity of the APC-fizzy related complex that regulates the exit from mitosis." [GOC:vw, PMID:10921876]
is_a: GO:1903835 ! positive regulation of APC-fizzy related complex activity
created_by: tanyaberardini
creation_date: 2015-01-21T16:22:24Z

[Term]
id: GO:0090624
name: endoribonuclease activity, cleaving miRNA-paired mRNA
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of the mRNA in a double-stranded RNA molecule formed by the base pairing of an mRNA with an miRNA." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:15260970, PMID:19239888]
is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters
relationship: part_of GO:0035279 ! mRNA cleavage involved in gene silencing by miRNA
created_by: tanyaberardini
creation_date: 2015-01-21T16:28:52Z

[Term]
id: GO:0090625
name: mRNA cleavage involved in gene silencing by siRNA
namespace: biological_process
def: "The process in which small interfering RNAs (siRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), a siRNA will typically direct cleavage by base pairing with perfect or near-perfect complementarity to the target mRNA." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:15260970]
is_a: GO:0098795 ! mRNA cleavage involved in gene silencing
intersection_of: GO:0006379 ! mRNA cleavage
intersection_of: part_of GO:0016246 ! RNA interference
relationship: part_of GO:0016246 ! RNA interference
created_by: tanyaberardini
creation_date: 2015-01-21T17:15:13Z

[Term]
id: GO:0090626
name: plant epidermis morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the plant epidermis are generated and organized." [GOC:tb]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0090558 ! plant epidermis development
created_by: tanyaberardini
creation_date: 2015-01-29T14:54:03Z

[Term]
id: GO:0090627
name: plant epidermal cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a plant epidermal cell." [GOC:tb]
is_a: GO:0030154 ! cell differentiation
created_by: tanyaberardini
creation_date: 2015-02-05T14:23:28Z

[Term]
id: GO:0090628
name: plant epidermal cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a plant epidermal cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:tb]
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0090627 ! plant epidermal cell differentiation
created_by: tanyaberardini
creation_date: 2015-02-06T17:32:21Z

[Term]
id: GO:0090629
name: lagging strand initiation
namespace: biological_process
def: "The process in which the synthesis of DNA from a template strand in a net 3' to 5' direction is started." [GOC:mah, GOC:tb]
is_a: GO:0006259 ! DNA metabolic process
relationship: part_of GO:0006273 ! lagging strand elongation
created_by: tanyaberardini
creation_date: 2015-02-11T14:37:13Z

[Term]
id: GO:0090630
name: activation of GTPase activity
namespace: biological_process
alt_id: GO:0032856
alt_id: GO:0032857
alt_id: GO:0032858
alt_id: GO:0032859
alt_id: GO:0032860
alt_id: GO:0032861
alt_id: GO:0032862
alt_id: GO:0032863
alt_id: GO:0032864
def: "Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]
synonym: "activation of ARF GTPase activity" NARROW []
synonym: "activation of Cdc42 GTPase activity" NARROW []
synonym: "activation of Rab GTPase activity" NARROW []
synonym: "activation of Rac GTPase activity" NARROW []
synonym: "activation of Ral GTPase activity" NARROW []
synonym: "activation of Ran GTPase activity" NARROW []
synonym: "activation of Rap GTPase activity" NARROW []
synonym: "activation of Ras GTPase activity" NARROW []
synonym: "activation of Rho GTPase activity" NARROW []
synonym: "ARF GTPase activation" NARROW []
synonym: "Cdc42 GTPase activation" NARROW []
synonym: "Rab GTPase activation" NARROW []
synonym: "Rac GTPase activation" NARROW []
synonym: "Ral GTPase activation" NARROW []
synonym: "Ran GTPase activation" NARROW []
synonym: "Rap GTPase activation" NARROW []
synonym: "Ras GTPase activation" NARROW []
synonym: "Rho GTPase activation" NARROW []
is_a: GO:0043547 ! positive regulation of GTPase activity
created_by: tanyaberardini
creation_date: 2015-02-11T16:09:19Z

[Term]
id: GO:0090631
name: pre-miRNA transporter activity
namespace: molecular_function
def: "Enables the directed movement of pre-miRNAs between the nucleus and the cytoplasm of a cell." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:14681208]
is_a: GO:0005487 ! nucleocytoplasmic transporter activity
created_by: tanyaberardini
creation_date: 2015-03-18T16:26:03Z

[Term]
id: GO:0090632
name: N-glycolylneuraminic acid (Neu5Gc) cytidylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CTP + Neu5Gc = diphosphate + CMP-Neu5Gc." [ISBN:978-1-60805-067-3, PMID:11479279, PMID:8381411]
synonym: "CMP-Neu5Gc synthetase activity" EXACT []
is_a: GO:0070567 ! cytidylyltransferase activity
created_by: tanyaberardini
creation_date: 2015-03-19T15:05:54Z

[Term]
id: GO:0090633
name: keto-deoxynonulosonic acid (KDN) cytidylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CTP + KDN = diphosphate + CMP-KDN." [ISBN:978-1-60805-067-3, PMID:11479279, PMID:8381411]
synonym: "CMP-KDN synthetase activity" EXACT []
synonym: "cytidine 5'-monophospho-2-Keto-3-deoxy-D-glycero-D-galacto-nononic acid synthetase activity" EXACT []
is_a: GO:0070567 ! cytidylyltransferase activity
created_by: tanyaberardini
creation_date: 2015-03-19T15:05:54Z

[Term]
id: GO:0090634
name: microglial cell mediated cytotoxicity
namespace: biological_process
def: "The directed killing of a target cell by a microglial cell." [GOC:BHF, GOC:nc, PMID:19100238]
is_a: GO:0001909 ! leukocyte mediated cytotoxicity
is_a: GO:0002444 ! myeloid leukocyte mediated immunity
created_by: tanyaberardini
creation_date: 2015-04-14T14:04:54Z

[Term]
id: GO:0090635
name: extracellular core region of desmosome
namespace: cellular_component
def: "The desmosomal part containing the desmosomal cadherins, desmogleins and desmocollins, that establish contact and adhere to neighboring cells in a Ca2+-dependent manner." [PMID:20066089]
synonym: "desmoglea" EXACT [PMID:20066089]
is_a: GO:0044464 ! cell part
relationship: part_of GO:0030057 ! desmosome
created_by: tanyaberardini
creation_date: 2015-04-20T16:10:51Z

[Term]
id: GO:0090636
name: outer dense plaque of desmosome
namespace: cellular_component
def: "The desmosomal part containing plakoglobins, plakophilins, the N-termini of desmoplakins,  as well as the cytoplasmic tails of the desmosomal cadherins, which together attach the plaque to the plasma membrane." [PMID:20066089]
is_a: GO:0044464 ! cell part
relationship: part_of GO:0030057 ! desmosome
created_by: tanyaberardini
creation_date: 2015-04-20T16:10:51Z

[Term]
id: GO:0090637
name: inner dense plaque of desmosome
namespace: cellular_component
def: "The desmosomal part containing the C-termini of desmoplakins which interact with the keratin intermediate filaments, serving to tether the intermediate filaments to the plasma membrane." [PMID:20066089]
is_a: GO:0044464 ! cell part
relationship: part_of GO:0030057 ! desmosome
created_by: tanyaberardini
creation_date: 2015-04-20T16:10:51Z

[Term]
id: GO:0090638
name: phosphatidylcholine biosynthesis from phosphatidylethanolamine
namespace: biological_process
def: "The phosphatidylcholine biosynthetic process that depends on direct conversion of the phosphatidyl-base phosphatidylethanolamine to phosphatidylcholine by successive methylations." [MetaCyc:PWY-6825]
is_a: GO:0006656 ! phosphatidylcholine biosynthetic process
created_by: tanyaberardini
creation_date: 2015-04-23T15:56:12Z

[Term]
id: GO:0090639
name: phosphatidylcholine biosynthesis from choline and CDP-diacylglycerol
namespace: biological_process
def: "The phosphatidylcholine biosynthetic process that involves a one-step direct condensation of choline with CDP-diacylglycerol to form phosphatidylcholine." [MetaCyc:PWY-6826]
is_a: GO:0006656 ! phosphatidylcholine biosynthetic process
created_by: tanyaberardini
creation_date: 2015-04-23T15:56:12Z

[Term]
id: GO:0090640
name: phosphatidylcholine biosynthesis from sn-glycero-3-phosphocholine
namespace: biological_process
def: "The phosphatidylcholine biosynthetic process that involves the two-step acylation of sn-glycero-3-phosphocholine to a phosphatidylcholine." [MetaCyc:PWY-7470, PMID:24329598]
is_a: GO:0006656 ! phosphatidylcholine biosynthetic process
created_by: tanyaberardini
creation_date: 2015-04-23T15:56:12Z

[Term]
id: GO:0090641
name: microsporidian-type endospore
namespace: cellular_component
def: "The middle layer in a microsporidian spore wall that lies under the exospore and outside the plasma membrane, containing chitin and proteins." [PMID:19457051]
comment: Microsporidian biology uses the term endospore differently than GO:0043593 endospore coat which is for a spore formed inside of another cell. Microsporidian endospore refers to the inner layer of the spore wall itself.
is_a: GO:0044426 ! cell wall part
relationship: part_of GO:0031160 ! spore wall
created_by: tanyaberardini
creation_date: 2015-05-04T14:17:06Z

[Term]
id: GO:0090642
name: microsporidian-type exospore
namespace: cellular_component
def: "The dense, protein rich outermost layer of a microsporidian spore wall that lies above the endospore." [PMID:19457051, PMID:25363531]
is_a: GO:0044426 ! cell wall part
relationship: part_of GO:0031160 ! spore wall
created_by: tanyaberardini
creation_date: 2015-05-04T14:17:06Z

[Term]
id: GO:0090643
name: inflorescence phyllotactic patterning
namespace: biological_process
def: "The radial pattern formation process that results in the formation of flowers around a central axis in an inflorescence meristem." [PMID:25352850]
is_a: GO:0060771 ! phyllotactic patterning
created_by: tanyaberardini
creation_date: 2015-05-05T14:25:09Z

[Term]
id: GO:0090644
name: age-related resistance
namespace: biological_process
def: "An innate immune response that is positively correlated with host plant development. As a plant develops, its innate resistance to pathogenic infections increases. The mechanisms involved in age-related resistance differ in nature or in aspects of regulation from the hypersensitive response (HR), systemic acquired resistance (SAR), or induced systemic resistance (ISR)." [PMID:17635216, PMID:19694953]
synonym: "adult seedling resistance" NARROW []
synonym: "ARR" EXACT []
synonym: "developmental resistance" BROAD []
synonym: "flowering-induced resistance" NARROW []
synonym: "mature seedling resistance" NARROW []
synonym: "ontogenic resistance" BROAD []
synonym: "senescence-induced resistance" NARROW []
is_a: GO:0044767 ! single-organism developmental process
is_a: GO:0045087 ! innate immune response
created_by: tanyaberardini
creation_date: 2015-05-19T10:36:38Z

[Term]
id: GO:0090645
name: APC-Cdc20 complex inhibitor activity
namespace: molecular_function
def: "Prevents the activation of the APC-Cdc20 complex activity to negatively regulate the mitotic metaphase anaphase transition." [GOC:vw]
comment: this term is only for gene products which bind to and directly inhibit the APC-Cdc20 complex (i.e the MCC complex).
is_a: GO:0061637 ! mitotic anaphase-promoting complex inhibitor activity
relationship: part_of GO:0045841 ! negative regulation of mitotic metaphase/anaphase transition
created_by: tanyaberardini
creation_date: 2015-05-21T14:44:43Z

[Term]
id: GO:0090646
name: mitochondrial tRNA processing
namespace: biological_process
def: "The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group,  in the mitochondrion." [GOC:vw]
is_a: GO:0000963 ! mitochondrial RNA processing
is_a: GO:0008033 ! tRNA processing
created_by: tanyaberardini
creation_date: 2015-06-12T15:57:13Z

[Term]
id: GO:0090647
name: modulation of age-related behavioral decline
namespace: biological_process
def: "Any process that modulates the processes that arise as an organism progresses toward the end of its lifespan that results in a decline in behavioral activities such as locomotory behavior, and learning or memory." [GOC:cjm, GOC:kmv, PMID:20523893]
is_a: GO:0065008 ! regulation of biological quality
relationship: part_of GO:0007568 ! aging
created_by: tanyaberardini
creation_date: 2015-06-15T12:45:44Z

[Term]
id: GO:0090648
name: response to environmental enrichment
namespace: biological_process
def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the provision of a combination of complex inanimate and social stimulations in the organism's housing environment." [GOC:sl, PMID:23644055, PMID:25934034]
synonym: "response to the introduction of novel objects" NARROW []
is_a: GO:0009605 ! response to external stimulus
created_by: tanyaberardini
creation_date: 2015-07-01T10:20:37Z

[Term]
id: GO:0090649
name: response to oxygen-glucose deprivation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the deprivation of oxygen and glucose." [GOC:sl, PMID:21525936]
synonym: "response to OGD" EXACT [GOC:sl]
is_a: GO:0031667 ! response to nutrient levels
is_a: GO:0036293 ! response to decreased oxygen levels
created_by: tanyaberardini
creation_date: 2015-07-01T10:27:29Z

[Term]
id: GO:0090650
name: cellular response to oxygen-glucose deprivation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the deprivation of oxygen and glucose." [GOC:sl, PMID:21525936]
synonym: "cellular response to OGD" EXACT [GOC:sl]
is_a: GO:0031669 ! cellular response to nutrient levels
is_a: GO:0036294 ! cellular response to decreased oxygen levels
is_a: GO:0090649 ! response to oxygen-glucose deprivation
created_by: tanyaberardini
creation_date: 2015-07-01T10:27:29Z

[Term]
id: GO:0090651
name: apical cytoplasm
namespace: cellular_component
def: "The region of the cytoplasm located at the apical side of the cell. Used in reference to animal polarized epithelial cells." [PMID:17494872]
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0005737 ! cytoplasm
relationship: part_of GO:0045177 ! apical part of cell
created_by: tanyaberardini
creation_date: 2015-07-01T15:46:19Z

[Term]
id: GO:0090652
name: basolateral cytoplasm
namespace: cellular_component
def: "The region of the cytoplasm located at the basolateral side of the cell. Used in reference to animal polarized epithelial cells." [PMID:17494872]
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0005737 ! cytoplasm
created_by: tanyaberardini
creation_date: 2015-07-01T15:46:19Z

[Term]
id: GO:0090653
name: apical recycling endosome
namespace: cellular_component
def: "Tubulo-vesicular structure located in the apical cytoplasm that participates in apical cargo recycling in polarized epithelial cells." [PMID:12669082, PMID:16394106, PMID:17494872, PMID:21170358, PMID:9405315]
is_a: GO:0055037 ! recycling endosome
relationship: part_of GO:0090651 ! apical cytoplasm
created_by: tanyaberardini
creation_date: 2015-07-01T15:46:19Z

[Term]
id: GO:0090654
name: basolateral recycling endosome
namespace: cellular_component
def: "Tubulo-vesicular structure located in the basolateral cytoplasm that participates in basolateral cargo recycling in polarized epithelial cells." [PMID:11389442, PMID:16394106, PMID:17494872, PMID:21170358, PMID:9405315]
is_a: GO:0055037 ! recycling endosome
relationship: part_of GO:0090652 ! basolateral cytoplasm
created_by: tanyaberardini
creation_date: 2015-07-01T15:46:19Z

[Term]
id: GO:0090655
name: double-stranded/single-stranded junction telomeric DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the junction formed at the point where double-stranded telomeric DNA becomes a single-stranded G-rich telomeric DNA 3' overhang." [GOC:BHF, GOC:BHF_telomere, GOC:bhm, GOC:nc, PMID:21852327]
is_a: GO:0000406 ! double-strand/single-strand DNA junction binding
is_a: GO:0042162 ! telomeric DNA binding
created_by: tanyaberardini
creation_date: 2015-07-02T11:33:39Z

[Term]
id: GO:0090656
name: t-circle formation
namespace: biological_process
def: "A telomere maintenance process that results in the formation of a telomeric circle, or t-circle. A t-circle is an extrachromosomal duplex or single-stranded circular DNA molecule composed of t-arrays. T-circles are involved in the control of telomere length via alternative-lengthening of telomeres (ALT) pathway and telomere rapid deletion (TRD)." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:19214183, PMID:19581589, PMID:19809492, PMID:19858100]
synonym: "telomeric circle formation" EXACT []
is_a: GO:0000723 ! telomere maintenance
created_by: tanyaberardini
creation_date: 2015-07-02T11:44:23Z

[Term]
id: GO:0090657
name: telomeric loop disassembly
namespace: biological_process
def: "The telomere maintenance process in which telomeric loops are disassembled to permit efficient telomere replication." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:22579284]
synonym: "T loop disassembly" EXACT []
synonym: "t-loop disassembly" EXACT []
is_a: GO:0000723 ! telomere maintenance
created_by: tanyaberardini
creation_date: 2015-07-07T13:53:40Z

[Term]
id: GO:0090658
name: cone matrix sheath
namespace: cellular_component
def: "A biochemically and structurally distinct domain of the retinal interphotoreceptor matrix that is specifically associated with cone photoreceptor cell inner and outer segments." [GOC:mr, PMID:2055688]
is_a: GO:0044420 ! extracellular matrix component
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0033165 ! interphotoreceptor matrix
created_by: tanyaberardini
creation_date: 2015-07-15T13:35:32Z

[Term]
id: GO:0090659
name: walking behavior
namespace: biological_process
def: "The behavior of an organism relating to the progression of that organism along the ground by the process of lifting and setting down each leg." [GOC:tb]
synonym: "locomotor gait pattern" NARROW []
is_a: GO:0007626 ! locomotory behavior
created_by: tanyaberardini
creation_date: 2015-08-27T16:34:28Z

[Term]
id: GO:0090660
name: cerebrospinal fluid circulation
namespace: biological_process
def: "The neurological system process driven by motile cilia on ependymal cells of the brain by which cerebrospinal fluid circulates from the sites of secretion to the sites of absorption. In ventricular cavities, the flow is unidirectional and rostrocaudal, in subarachnoid spaces, the flow is multi-directional." [GOC:mgi_curators, PMID:22100360, PMID:24229449]
synonym: "cerebrospinal fluid flow" EXACT []
synonym: "CSF circulation" EXACT []
synonym: "CSF flow" EXACT []
is_a: GO:0050877 ! neurological system process
relationship: has_part GO:0003351 ! epithelial cilium movement
created_by: tanyaberardini
creation_date: 2015-09-11T15:49:59Z

[Term]
id: GO:0090661
name: box H/ACA telomerase RNP complex
namespace: cellular_component
def: "A box H/ACA ribonucleoprotein complex that contains the RNA component of vertebrate telomerase, the enzyme essential for the replication of chromosome termini in most eukaryotes. This ribonucleoprotein complex is a structural box H/ACA RNP, which does not have the catalytic pseudouridylation function shared by the majority of H/ACA RNPs present in the cell." [GOC:BHF, GOC:BHF_telomere, GOC:jbu, PMID:22527283]
is_a: GO:0072588 ! box H/ACA RNP complex
created_by: tanyaberardini
creation_date: 2015-09-21T14:46:16Z

[Term]
id: GO:0090662
name: ATP hydrolysis coupled transmembrane transport
namespace: biological_process
def: "The transport of molecules across a membrane and against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:tb, PMID:18075585]
is_a: GO:0055085 ! transmembrane transport
created_by: tanyaberardini
creation_date: 2015-10-21T13:22:47Z

[Term]
id: GO:0090663
name: galanin-activated signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of the peptide neurotransmitter galanin binding to a cell surface receptor." [GOC:lb, PMID:25691535]
synonym: "galanin signaling pathway" RELATED []
synonym: "galanin signalling pathway" RELATED []
synonym: "galanin-activated signalling pathway" EXACT []
is_a: GO:0007218 ! neuropeptide signaling pathway
created_by: tanyaberardini
creation_date: 2015-10-21T13:38:04Z

[Term]
id: GO:0090664
name: response to high population density
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or a multicellular organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a higher than normal number of multicellular organisms living per unit area." [GOC:mr, PMID:26439857]
synonym: "response to crowding" EXACT [GOC:mr]
is_a: GO:0006950 ! response to stress
is_a: GO:0044707 ! single-multicellular organism process
created_by: tanyaberardini
creation_date: 2015-10-21T16:00:30Z

[Term]
id: GO:0090665
name: glycoprotein complex
namespace: cellular_component
def: "A protein complex containing at least one glycosylated protein, may be held together by both covalent and noncovalent bonds." [GOC:pf, PMID:7693675, PMID:8662961]
comment: An example is the Dictyostelium multi protein pspB complex, which is secreted from prespore vesicles and incorporated into the spore coat.
is_a: GO:0043234 ! protein complex
created_by: tanyaberardini
creation_date: 2015-12-11T17:45:23Z

[Term]
id: GO:0090666
name: scaRNA localization to Cajal body
namespace: biological_process
def: "A process in which a small Cajal body-specific RNA is transported to, or maintained in, a Cajal body." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444]
is_a: GO:0090670 ! RNA localization to Cajal body
created_by: tanyaberardini
creation_date: 2015-12-15T10:57:05Z

[Term]
id: GO:0090667
name: cell chemotaxis to vascular endothelial growth factor
namespace: biological_process
def: "The directed movement of a motile cell in response to the presence of vascular endothelial growth factor (VEGF)." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:21885851]
is_a: GO:0060326 ! cell chemotaxis
relationship: part_of GO:0035924 ! cellular response to vascular endothelial growth factor stimulus
created_by: tanyaberardini
creation_date: 2015-12-15T11:27:12Z

[Term]
id: GO:0090668
name: endothelial cell chemotaxis to vascular endothelial growth factor
namespace: biological_process
def: "The directed movement of an endothelial cell in response to the presence of vascular endothelial growth factor (VEGF)." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:21885851]
is_a: GO:0090667 ! cell chemotaxis to vascular endothelial growth factor
created_by: tanyaberardini
creation_date: 2015-12-15T11:31:43Z

[Term]
id: GO:0090669
name: telomerase RNA stabilization
namespace: biological_process
def: "Prevention of degradation of telomerase RNA (TERC) molecules." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444]
synonym: "TERC stabilization" EXACT []
is_a: GO:0043489 ! RNA stabilization
created_by: tanyaberardini
creation_date: 2015-12-17T14:01:11Z

[Term]
id: GO:0090670
name: RNA localization to Cajal body
namespace: biological_process
def: "A process in which an RNA is transported to, or maintained in, a Cajal body." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444]
is_a: GO:0006403 ! RNA localization
created_by: tanyaberardini
creation_date: 2015-12-17T14:04:40Z

[Term]
id: GO:0090671
name: telomerase RNA localization to Cajal body
namespace: biological_process
def: "A process in which telomerase RNA (TERC) is transported to, or maintained in, a Cajal body." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444]
is_a: GO:0090670 ! RNA localization to Cajal body
is_a: GO:0090672 ! telomerase RNA localization
created_by: tanyaberardini
creation_date: 2015-12-17T14:06:21Z

[Term]
id: GO:0090672
name: telomerase RNA localization
namespace: biological_process
def: "Any process in which telomerase RNA is transported to, or maintained in, a specific location." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444]
is_a: GO:0006403 ! RNA localization
created_by: tanyaberardini
creation_date: 2015-12-17T14:08:01Z

[Term]
id: GO:0090673
name: endothelial cell-matrix adhesion
namespace: biological_process
def: "The binding of an endothelial cell to the extracellular matrix via adhesion molecules." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:19460962]
is_a: GO:0007160 ! cell-matrix adhesion
created_by: tanyaberardini
creation_date: 2016-01-15T15:38:11Z

[Term]
id: GO:0090674
name: endothelial cell-matrix adhesion via fibronectin
namespace: biological_process
def: "The binding of an endothelial cell to the extracellular matrix via fibronectin." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:19460962]
is_a: GO:0090673 ! endothelial cell-matrix adhesion
created_by: tanyaberardini
creation_date: 2016-01-15T15:40:58Z

[Term]
id: GO:0090675
name: intermicrovillar adhesion
namespace: biological_process
def: "The biological adhesion process by which adjacent microvilli attach to each other through Ca(2+)-dependent adhesion links made of protocadherin-24 and mucin-like protocadherin." [GOC:lb, PMID:24725409]
is_a: GO:0022610 ! biological adhesion
relationship: part_of GO:1904970 ! brush border assembly
created_by: tanyaberardini
creation_date: 2016-02-19T13:34:07Z

[Term]
id: GO:0090676
name: calcium ion transmembrane transport via low voltage-gated calcium channel
namespace: biological_process
def: "A process in which a calcium ion is transported from one side of a membrane to the other by means of a low voltage-gated calcium channel." [GOC:bf]
synonym: "generation of T-type calcium current" RELATED []
is_a: GO:0070588 ! calcium ion transmembrane transport
relationship: has_part GO:0008332 ! low voltage-gated calcium channel activity
created_by: tanyaberardini
creation_date: 2016-03-23T10:15:23Z

[Term]
id: GO:0093001
name: glycolysis from storage polysaccharide through glucose-1-phosphate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a storage polysaccharide into pyruvate through a glucose-1-phosphate intermediate, with the concomitant production of a small amount of ATP and the reduction of NAD to NADH." [GOC:dph, GOC:glycolysis]
is_a: GO:0000272 ! polysaccharide catabolic process
is_a: GO:0061622 ! glycolytic process through glucose-1-phosphate

[Term]
id: GO:0093002
name: response to nematicide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nematicide stimulus. Nematicides are chemicals used to kill nematodes." [GOC:kvm, PMID:22301316]
synonym: "response to antihelmintic" EXACT [GOC:kvm]
synonym: "response to nematocide" EXACT [GOC:kvm]
is_a: GO:0009636 ! response to toxic substance

[Term]
id: GO:0095500
name: acetylcholine receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of an acetylcholine receptor binding to one of its physiological ligands." [GOC:mah]
synonym: "acetylcholine receptor signalling pathway" EXACT []
is_a: GO:0098926 ! postsynaptic signal transduction
is_a: GO:1903831 ! signal transduction involved in cellular response to ammonium ion
relationship: part_of GO:1905145 ! cellular response to acetylcholine

[Term]
id: GO:0097001
name: ceramide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any ceramide, a class of lipids that is composed of sphingosine linked to a fatty acid. Ceramides are a major component of cell membranes." [CHEBI:17761, GOC:sart]
is_a: GO:0033218 ! amide binding
is_a: GO:0046625 ! sphingolipid binding
created_by: paola
creation_date: 2011-03-09T11:34:09Z

[Term]
id: GO:0097002
name: mitochondrial inner boundary membrane
namespace: cellular_component
def: "The portion of the mitochondrial inner membrane that is not invaginated to form cristae. The inner boundary membrane lies parallel to the outer membrane." [GOC:mcc, PMID:16054341, PMID:19019989]
synonym: "inner bounding mitochondrial membrane" EXACT [NIF_Subcellular:sao18461326]
xref: NIF_Subcellular:sao18461326
is_a: GO:0044455 ! mitochondrial membrane part
relationship: part_of GO:0005743 ! mitochondrial inner membrane
created_by: paola
creation_date: 2011-03-10T04:11:50Z

[Term]
id: GO:0097003
name: adipokinetic hormone receptor activity
namespace: molecular_function
def: "Combining with an adipokinetic hormone to initiate a change in cell activity. Adipokinetic hormones (AKHs) are peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis." [GOC:sart, PMID:11904407]
synonym: "AKH receptor activity" EXACT []
is_a: GO:0016500 ! protein-hormone receptor activity
relationship: has_part GO:0055100 ! adiponectin binding
relationship: has_part GO:0097004 ! adipokinetic hormone binding
created_by: paola
creation_date: 2011-03-14T10:24:08Z

[Term]
id: GO:0097004
name: adipokinetic hormone binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an adipokinetic hormone. Adipokinetic hormones (AKHs) are peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis." [GOC:sart, PMID:11904407]
synonym: "AKH binding" EXACT []
is_a: GO:0017046 ! peptide hormone binding
created_by: paola
creation_date: 2011-03-14T12:50:02Z

[Term]
id: GO:0097005
name: adipokinetic hormone receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an adipokinetic hormone receptor. Adipokinetic hormones (AKHs) are peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis." [GOC:sart, PMID:11904407]
synonym: "AKH receptor binding" EXACT []
is_a: GO:0051428 ! peptide hormone receptor binding
created_by: paola
creation_date: 2011-03-14T12:58:19Z

[Term]
id: GO:0097006
name: regulation of plasma lipoprotein particle levels
namespace: biological_process
def: "Any process involved in the maintenance of internal levels of plasma lipoprotein particles within an organism." [GOC:BHF]
synonym: "plasma lipoprotein particle homeostasis" NARROW []
is_a: GO:0050789 ! regulation of biological process
created_by: paola
creation_date: 2011-03-15T09:52:53Z

[Term]
id: GO:0097007
name: 4,8,12-trimethyltrideca-1,3,7,11-tetraene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (EE)-geranyllinalool + NADPH + O2 = 4,8,12-trimethyl-1,3,7,11-tridecatetraene + NADP+ + 2 H2O. It is unknown whether this reaction proceeds by the direct release of the 4-carbon compound but-1-en-3-one, or whether the substrate is first degraded to C18-farnesylacetone and then cleaved to produce 4,8,12-trimethyl-1,3,7,11-tridecatetraene (TMTT) and acetone." [GOC:kad, MetaCyc:RXN-8620, PMID:21088219]
synonym: "4,8,12-trimethyl-1,3,7,11-tridecatetraene synthase activity" EXACT []
synonym: "TMTT synthase activity" EXACT []
xref: MetaCyc:RXN-8620
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
created_by: paola
creation_date: 2011-03-16T04:37:20Z

[Term]
id: GO:0097008
name: (3E)-4,8-dimethyl-1,3,7-nonatriene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (E)-nerolidol + NADPH + O2 = (3E)-4,8-dimethylnona-1,3,7-triene + NADP+ + 2 H2O. It is unknown whether this reaction proceeds by the direct release of the 4-carbon compound but-1-en-3-one, or whether the substrate is first degraded to C11-geranylacetone and then cleaved to produce (3E)-4,8-dimethylnona-1,3,7-triene (DMNT) and acetone." [GOC:kad, MetaCyc:RXN-8619, PMID:21088219]
synonym: "(3E)-4,8-dimethylnona-1,3,7-triene synthase activity" EXACT []
synonym: "DMNT synthase activity" EXACT []
xref: MetaCyc:RXN-8619
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
created_by: paola
creation_date: 2011-03-17T10:38:01Z

[Term]
id: GO:0097009
name: energy homeostasis
namespace: biological_process
def: "Any process involved in the balance between food intake (energy input) and energy expenditure." [GOC:yaf, PMID:15919751]
is_a: GO:0048871 ! multicellular organismal homeostasis
created_by: paola
creation_date: 2011-03-17T02:57:38Z

[Term]
id: GO:0097010
name: eukaryotic translation initiation factor 4F complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the eukaryotic translation initiation factor 4F complex." [GOC:BHF, GOC:ebc, PMID:18337562]
synonym: "eIF-4F assembly" EXACT [GOC:pr]
synonym: "eIF4F assembly" EXACT [GOC:pr]
is_a: GO:0043623 ! cellular protein complex assembly
created_by: paola
creation_date: 2011-03-21T04:19:26Z

[Term]
id: GO:0097011
name: cellular response to granulocyte macrophage colony-stimulating factor stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte macrophage colony-stimulating factor stimulus." [GOC:BHF, GOC:ebc, PMID:7901744]
synonym: "cellular response to GM-CSF stimulus" EXACT []
is_a: GO:0071345 ! cellular response to cytokine stimulus
is_a: GO:0097012 ! response to granulocyte macrophage colony-stimulating factor
created_by: paola
creation_date: 2011-03-21T05:25:06Z

[Term]
id: GO:0097012
name: response to granulocyte macrophage colony-stimulating factor
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte macrophage colony-stimulating factor stimulus." [GOC:pr]
synonym: "response to GM-CSF" EXACT []
synonym: "response to granulocyte macrophage colony-stimulating factor stimulus" EXACT [GOC:dos]
is_a: GO:0034097 ! response to cytokine
created_by: paola
creation_date: 2011-03-22T01:12:15Z

[Term]
id: GO:0097013
name: phagocytic vesicle lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of a phagocytic vesicle." [GOC:rs]
is_a: GO:0071682 ! endocytic vesicle lumen
intersection_of: GO:0031974 ! membrane-enclosed lumen
intersection_of: part_of GO:0045335 ! phagocytic vesicle
relationship: part_of GO:0045335 ! phagocytic vesicle
created_by: paola
creation_date: 2011-03-22T01:44:47Z

[Term]
id: GO:0097014
name: ciliary plasm
namespace: cellular_component
def: "All of the contents of a cilium, excluding the plasma membrane surrounding the cilium." [GOC:BHF, GOC:cilia, GOC:dos, PMID:17895364]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. Also, researchers consider the composition of both the plasm and the membrane of the cilium to be detectably different from that in the non-ciliary cytosol and plasma membrane (e.g. in terms of calcium ion concentration, membrane lipid composition, and more). For this reason, the term "ciliary plasm" is not linked to "cytoplasm".
synonym: "cilial cytoplasm" RELATED []
synonym: "ciliary cytoplasm" RELATED []
synonym: "cilium cytoplasm" RELATED []
synonym: "cilium plasm" EXACT []
synonym: "microtubule-based flagellar cytoplasm" RELATED []
synonym: "microtubule-based flagellar matrix" NARROW []
synonym: "microtubule-based flagellum cytoplasm" RELATED []
synonym: "microtubule-based flagellum matrix" NARROW []
is_a: GO:0044441 ! ciliary part
created_by: paola
creation_date: 2011-03-23T01:52:31Z

[Term]
id: GO:0097015
name: bacterial-type flagellar cytoplasm
namespace: cellular_component
def: "All of the contents of a bacterial-type flagellum, excluding the plasma membrane surrounding the flagellum." [GOC:BHF]
synonym: "bacterial-type flagellum cytoplasm" EXACT []
is_a: GO:0032838 ! cell projection cytoplasm
is_a: GO:0044461 ! bacterial-type flagellum part
intersection_of: GO:0032838 ! cell projection cytoplasm
intersection_of: part_of GO:0009288 ! bacterial-type flagellum
relationship: part_of GO:0009288 ! bacterial-type flagellum
created_by: paola
creation_date: 2011-03-23T01:59:44Z

[Term]
id: GO:0097016
name: L27 domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a L27 domain of a protein. L27 is composed of conserved negatively charged amino acids and a conserved aromatic amino acid. L27 domains can assemble proteins involved in signaling and establishment and maintenance of cell polarity into complexes by interacting in a heterodimeric manner." [GOC:BHF, PMID:15241471, PMID:17237226, Prosite:PDOC51022]
is_a: GO:0019904 ! protein domain specific binding
created_by: paola
creation_date: 2011-03-23T02:17:51Z

[Term]
id: GO:0097017
name: renal protein absorption
namespace: biological_process
def: "A renal system process in which proteins are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures (e.g. protein absorption is observed in nephrocytes in Drosophila, see PMID:23264686)." [GOC:yaf, PMID:18431508]
is_a: GO:0070293 ! renal absorption
created_by: paola
creation_date: 2011-03-23T03:13:04Z

[Term]
id: GO:0097018
name: renal albumin absorption
namespace: biological_process
def: "A renal system process in which albumin is taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron." [GOC:yaf, PMID:18431508]
is_a: GO:0097017 ! renal protein absorption
created_by: paola
creation_date: 2011-03-23T03:15:04Z

[Term]
id: GO:0097019
name: neurotransmitter receptor catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of neurotransmitter receptors." [GOC:kmv]
synonym: "neurotransmitter receptor breakdown" EXACT []
synonym: "neurotransmitter receptor catabolism" EXACT []
synonym: "neurotransmitter receptor degradation" EXACT []
is_a: GO:0032801 ! receptor catabolic process
is_a: GO:0045213 ! neurotransmitter receptor metabolic process
created_by: paola
creation_date: 2011-03-23T04:16:11Z

[Term]
id: GO:0097020
name: COPII adaptor activity
namespace: molecular_function
def: "The binding activity of a molecule that brings together the COPII vesicle proteins and one or more other molecules, permitting them to function in a coordinated way." [GOC:rb, PMID:16957051, PMID:20236934]
is_a: GO:0030674 ! protein binding, bridging
created_by: paola
creation_date: 2011-03-24T04:19:55Z

[Term]
id: GO:0097021
name: lymphocyte migration into lymphoid organs
namespace: biological_process
def: "The movement of a lymphocyte within the lymphatic system into lymphoid organs such as lymph nodes, spleen or Peyer's patches, and its subsequent positioning within defined functional compartments such as sites of cell activation by antigen." [GOC:BHF, GOC:pr, PMID:18379575]
synonym: "lymphocyte homing" NARROW []
is_a: GO:0072676 ! lymphocyte migration
created_by: paola
creation_date: 2011-03-29T04:26:08Z

[Term]
id: GO:0097022
name: lymphocyte migration into lymph node
namespace: biological_process
def: "The movement of a lymphocyte within the lymphatic system into a lymph node, and its subsequent positioning within defined functional compartments such as sites of cell activation by antigen." [GOC:BHF, GOC:pr, PMID:18379575]
synonym: "lymphocyte homing" EXACT []
is_a: GO:0097021 ! lymphocyte migration into lymphoid organs
created_by: paola
creation_date: 2011-03-29T04:29:27Z

[Term]
id: GO:0097023
name: fructose 6-phosphate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-fructose-6-phosphate = dihydroxyacetone + D-glyceraldehyde-3-phosphate." [GOC:imk, PMID:11120740, PMID:21290439]
xref: RHEA:28005
is_a: GO:0016832 ! aldehyde-lyase activity
created_by: paola
creation_date: 2011-03-29T04:54:05Z

[Term]
id: GO:0097025
name: MPP7-DLG1-LIN7 complex
namespace: cellular_component
def: "A heterotrimeric protein complex formed by the association of MMP7, DLG1 and either LIN7A or LIN7C; regulates the stability and localization of DLG1 to cell junctions." [GOC:BHF, PMID:17237226]
is_a: GO:0098797 ! plasma membrane protein complex
relationship: part_of GO:0005912 ! adherens junction
created_by: paola
creation_date: 2011-03-30T05:03:33Z

[Term]
id: GO:0097026
name: dendritic cell dendrite assembly
namespace: biological_process
def: "Formation of dendrites, branched cellular projections (or cytoplasmic extension) that are extended from the surface of a dendritic immune cell, and which enable the cell to sample luminal pathogens and increase the surface area for antigen presentation to T cells." [CL:0000451, GOC:BHF, PMID:12200351]
comment: Note that dendrites of dendritic cells should not be confused with neuronal cell dendrites, which process electrical signals.
synonym: "dendritic extension" BROAD []
is_a: GO:0030031 ! cell projection assembly
created_by: paola
creation_date: 2011-03-31T04:52:53Z

[Term]
id: GO:0097027
name: ubiquitin-protein transferase activator activity
namespace: molecular_function
def: "Increases the activity of a ubiquitin-protein transferase, an enzyme that catalyzes the covalent attachment of ubiquitin to lysine in a substrate protein." [GOC:rb, PMID:18321851]
is_a: GO:0055106 ! ubiquitin-protein transferase regulator activity
relationship: positively_regulates GO:0004842 ! ubiquitin-protein transferase activity
created_by: paola
creation_date: 2011-03-31T05:19:23Z

[Term]
id: GO:0097028
name: dendritic cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a dendritic cell. A dendritic cell is a leukocyte of dendritic lineage specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation." [CL:0000451, GOC:pr]
comment: Note that immunologists typically use the word 'maturation' to refer to dendritic cells undergoing the process that GO describes as 'cell differentiation'.
is_a: GO:0002521 ! leukocyte differentiation
created_by: paola
creation_date: 2011-04-01T10:08:42Z

[Term]
id: GO:0097029
name: mature conventional dendritic cell differentiation
namespace: biological_process
def: "The process in which antigen-activated dendritic cells acquire the specialized features of a mature conventional dendritic cell. Mature conventional dendritic cells upregulate the surface expression of MHC molecules, chemokine receptors and adhesion molecules, and increase the number of dendrites (cytoplasmic protrusions) in preparation for migration to lymphoid organs where they present antigen to T cells." [GOC:BHF, http://www.rndsystems.com/mini_review_detail_objectname_MR02_DendriticCellMat.aspx, PMID:15845453]
comment: Note that immunologists typically use the word 'maturation' to refer to dendritic cells undergoing the process that GO describes as 'cell differentiation'.
is_a: GO:0002573 ! myeloid leukocyte differentiation
is_a: GO:0097028 ! dendritic cell differentiation
created_by: paola
creation_date: 2011-04-01T10:10:22Z

[Term]
id: GO:0097030
name: CENP-A containing nucleosome binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a centromere-specific nucleosome, a form of nucleosome located only at the centromere, in which the histone H3 is replaced by the variant form CENP-A (sometimes known as CenH3)." [GOC:jp, PMID:21412236]
synonym: "centromere-specific nucleosome binding" RELATED [GOC:vw]
synonym: "centromeric nucleosome binding" RELATED []
is_a: GO:0031491 ! nucleosome binding
created_by: paola
creation_date: 2011-04-01T03:19:35Z

[Term]
id: GO:0097031
name: mitochondrial respiratory chain complex I biogenesis
namespace: biological_process
def: "The biogenesis of a mitochondrial respiratory chain complex I, a protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Includes the synthesis of constituent proteins and their aggregation, arrangement and bonding together." [GOC:pr]
is_a: GO:0070271 ! protein complex biogenesis
created_by: paola
creation_date: 2011-04-05T02:53:14Z

[Term]
id: GO:0097032
name: mitochondrial respiratory chain complex II biogenesis
namespace: biological_process
def: "The biogenesis of a mitochondrial respiratory chain complex II, a protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Includes the synthesis of constituent proteins and their aggregation, arrangement and bonding together." [GOC:pr]
is_a: GO:0070271 ! protein complex biogenesis
created_by: paola
creation_date: 2011-04-05T02:57:33Z

[Term]
id: GO:0097033
name: mitochondrial respiratory chain complex III biogenesis
namespace: biological_process
def: "The biogenesis of a mitochondrial respiratory chain complex III (also known as cytochrome bc(1) complex or ubiquinol-cytochrome c reductase), a protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Includes the synthesis of constituent proteins and their aggregation, arrangement and bonding together." [GOC:mcc]
synonym: "mitochondrial cytochrome bc(1) complex biogenesis" EXACT [GOC:pr]
is_a: GO:0070271 ! protein complex biogenesis
created_by: paola
creation_date: 2011-04-05T03:00:31Z

[Term]
id: GO:0097034
name: mitochondrial respiratory chain complex IV biogenesis
namespace: biological_process
def: "The biogenesis of a mitochondrial respiratory chain complex IV (also known as cytochrome c oxidase complex), a protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Includes the synthesis of constituent proteins and their aggregation, arrangement and bonding together." [GOC:mcc]
synonym: "mitochondrial cytochrome c oxidase complex biogenesis" EXACT [GOC:pr]
is_a: GO:0070271 ! protein complex biogenesis
created_by: paola
creation_date: 2011-04-05T03:02:54Z

[Term]
id: GO:0097035
name: regulation of membrane lipid distribution
namespace: biological_process
def: "Any process that modulates the proportions or spatial arrangement of lipids in a cellular membrane." [GOC:mah, PMID:18441123, PMID:20823909]
is_a: GO:0044802 ! single-organism membrane organization
is_a: GO:0065008 ! regulation of biological quality
created_by: paola
creation_date: 2011-04-08T02:01:19Z

[Term]
id: GO:0097036
name: regulation of plasma membrane sterol distribution
namespace: biological_process
def: "Any process that modulates the proportions or spatial arrangement of sterols in the plasma membrane." [CHEBI:15889, GOC:mah, PMID:18441123, PMID:20823909]
is_a: GO:0007009 ! plasma membrane organization
is_a: GO:0097035 ! regulation of membrane lipid distribution
created_by: paola
creation_date: 2011-04-08T02:08:08Z

[Term]
id: GO:0097037
name: heme export
namespace: biological_process
def: "The directed movement of heme out of a cell or organelle." [GOC:lf, PMID:15369674, PMID:20610401]
is_a: GO:0015886 ! heme transport
created_by: paola
creation_date: 2011-04-11T10:39:22Z

[Term]
id: GO:0097038
name: perinuclear endoplasmic reticulum
namespace: cellular_component
def: "The portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. The lumen of the perinuclear endoplasmic reticulum is contiguous with the nuclear envelope lumen (also called perinuclear space), the region between the inner and outer nuclear membranes." [GOC:bf, GOC:mah, GOC:mcc, GOC:pr, GOC:vw]
synonym: "perinuclear ER" EXACT []
is_a: GO:0044432 ! endoplasmic reticulum part
relationship: part_of GO:0048471 ! perinuclear region of cytoplasm
created_by: paola
creation_date: 2011-04-12T10:51:05Z

[Term]
id: GO:0097039
name: protein linear polyubiquitination
namespace: biological_process
def: "A protein ubiquitination process in which a linear polymer of ubiquitin, formed by the amino-terminal methionine (M1) of one ubiquitin molecule and by the carboxy-terminal glycine (G76) of the next, is added to a protein." [GOC:jsg, GOC:sp, PMID:21455173, PMID:21455180, PMID:21455181]
synonym: "M1 linkage" NARROW []
is_a: GO:0000209 ! protein polyubiquitination
created_by: paola
creation_date: 2011-04-13T01:52:51Z

[Term]
id: GO:0097040
name: phthiocerol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phthiocerol, a lipid-based 1,3-glycol consisting of (3S,4R)-3-methoxy-4-methylnonacosane having (9R)- and (11S)-hydroxy substituents." [CHEBI:59240, GOC:dph, GOC:ecd, PMID:9201977]
synonym: "phthiocerol anabolism" EXACT []
synonym: "phthiocerol biosynthesis" EXACT []
synonym: "phthiocerol formation" EXACT []
synonym: "phthiocerol synthesis" EXACT []
is_a: GO:0008610 ! lipid biosynthetic process
is_a: GO:0042845 ! glycol biosynthetic process
created_by: paola
creation_date: 2011-04-15T01:18:17Z

[Term]
id: GO:0097041
name: phenolic phthiocerol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phenolic phthiocerol, a phthiocerol derivative having a 4-hydroxyphenyl substituent at the 29-position." [CHEBI:59237, GOC:dph, GOC:ecd, PMID:9201977]
synonym: "phenolic phthiocerol anabolism" EXACT []
synonym: "phenolic phthiocerol biosynthesis" EXACT []
synonym: "phenolic phthiocerol formation" EXACT []
synonym: "phenolic phthiocerol synthesis" EXACT []
synonym: "phenolphthiocerol biosynthesis" EXACT []
is_a: GO:0008610 ! lipid biosynthetic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0046173 ! polyol biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
created_by: paola
creation_date: 2011-04-15T01:25:59Z

[Term]
id: GO:0097042
name: extrinsic component of fungal-type vacuolar membrane
namespace: cellular_component
def: "The component of a fungal-type vacuolar membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:jh, PMID:21454883]
synonym: "extrinsic to fungal-type vacuolar membrane" NARROW []
is_a: GO:0000306 ! extrinsic component of vacuolar membrane
intersection_of: GO:0019898 ! extrinsic component of membrane
intersection_of: part_of GO:0000329 ! fungal-type vacuole membrane
relationship: part_of GO:0000329 ! fungal-type vacuole membrane
created_by: paola
creation_date: 2011-04-19T03:42:39Z

[Term]
id: GO:0097043
name: histone H3-K56 acetylation
namespace: biological_process
def: "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 56 of the histone." [GOC:bf, GOC:pr]
is_a: GO:0043966 ! histone H3 acetylation
created_by: paola
creation_date: 2011-04-19T05:18:29Z

[Term]
id: GO:0097044
name: histone H3-K56 acetylation in response to DNA damage
namespace: biological_process
def: "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 56 of the histone as a result of the detection of DNA damage within a cell." [GOC:pr, GOC:vw, PMID:18344406]
is_a: GO:0097043 ! histone H3-K56 acetylation
relationship: part_of GO:0006974 ! cellular response to DNA damage stimulus
created_by: paola
creation_date: 2011-04-19T05:22:54Z

[Term]
id: GO:0097045
name: phosphatidylserine exposure on blood platelet
namespace: biological_process
def: "A phospholipid scrambling process that results in the appearance of phosphatidylserine on the surface of activated blood platelets, and triggers the clotting system." [GOC:bf, GOC:lf, GOC:pr, PMID:21107324]
is_a: GO:0017121 ! phospholipid scrambling
is_a: GO:0030194 ! positive regulation of blood coagulation
created_by: paola
creation_date: 2011-04-20T12:54:35Z

[Term]
id: GO:0097046
name: replication fork progression beyond termination site
namespace: biological_process
def: "Regulation of DNA replication by a mechanism that allows a DNA replication fork to progress beyond a termination site, which is a region containing fork pausing elements that influence the progression and merging of DNA replication forks." [GOC:bf, GOC:mcc, GOC:pr, PMID:20797631]
is_a: GO:2000621 ! regulation of DNA replication termination
created_by: paola
creation_date: 2011-05-03T03:34:01Z

[Term]
id: GO:0097047
name: DNA replication termination region
namespace: cellular_component
def: "A chromosomal region that contains fork pausing elements influencing the progression and merging of DNA replication forks." [GOC:mcc, GOC:pr, PMID:20797631]
synonym: "TER" EXACT []
is_a: GO:0044427 ! chromosomal part
created_by: paola
creation_date: 2011-05-03T03:38:40Z

[Term]
id: GO:0097048
name: dendritic cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a dendritic cell, a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation." [CL:0000451, GOC:BHF, GOC:mtg_apoptosis, PMID:15059845]
synonym: "dendritic cell apoptosis" NARROW []
is_a: GO:0071887 ! leukocyte apoptotic process
created_by: paola
creation_date: 2011-05-04T02:18:59Z

[Term]
id: GO:0097049
name: motor neuron apoptotic process
namespace: biological_process
def: "Any apoptotic process in a motor neuron, an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement." [CL:0000100, GOC:BHF, GOC:mtg_apoptosis, PMID:14523086]
synonym: "motoneuron apoptosis" EXACT []
synonym: "motor neuron apoptosis" NARROW []
is_a: GO:0051402 ! neuron apoptotic process
created_by: paola
creation_date: 2011-05-04T02:21:43Z

[Term]
id: GO:0097050
name: type B pancreatic cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a type B pancreatic cell, a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:BHF, GOC:mtg_apoptosis, PMID:16087305]
synonym: "pancreatic B cell apoptosis" EXACT []
synonym: "pancreatic beta cell apoptosis" EXACT []
synonym: "type B pancreatic cell apoptosis" NARROW []
is_a: GO:1904019 ! epithelial cell apoptotic process
created_by: paola
creation_date: 2011-05-04T02:24:38Z

[Term]
id: GO:0097051
name: establishment of protein localization to endoplasmic reticulum membrane
namespace: biological_process
def: "The directed movement of a protein to a specific location in the endoplasmic reticulum membrane." [GOC:rb, PMID:9388185]
synonym: "establishment of protein localisation in endoplasmic reticulum membrane" EXACT [GOC:mah]
synonym: "establishment of protein localization in endoplasmic reticulum membrane" EXACT [GOC:curators]
is_a: GO:0072599 ! establishment of protein localization to endoplasmic reticulum
is_a: GO:0090150 ! establishment of protein localization to membrane
created_by: paola
creation_date: 2011-05-04T05:55:26Z

[Term]
id: GO:0097052
name: L-kynurenine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving L-kynurenine, the L-enantiomer of the amino acid kynurenine (3-(2-aminobenzoyl)-alanine)." [CHEBI:16946, GOC:yaf]
synonym: "L-kynurenine metabolism" EXACT []
is_a: GO:0070189 ! kynurenine metabolic process
created_by: paola
creation_date: 2011-05-24T03:28:44Z

[Term]
id: GO:0097053
name: L-kynurenine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-kynurenine, the L-enantiomer of the amino acid kynurenine (3-(2-aminobenzoyl)-alanine)." [CHEBI:16946, GOC:yaf]
synonym: "L-kynurenine breakdown" EXACT []
synonym: "L-kynurenine catabolism" EXACT []
synonym: "L-kynurenine degradation" EXACT []
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:0042219 ! cellular modified amino acid catabolic process
is_a: GO:0097052 ! L-kynurenine metabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901606 ! alpha-amino acid catabolic process
created_by: paola
creation_date: 2011-05-24T03:30:58Z

[Term]
id: GO:0097054
name: L-glutamate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-glutamate, the L enantiomer anion of 2-aminopentanedioic acid." [GOC:yaf]
synonym: "L-glutamate anabolism" EXACT []
synonym: "L-glutamate biosynthesis" EXACT []
synonym: "L-glutamate formation" EXACT []
synonym: "L-glutamate synthesis" EXACT []
is_a: GO:0006537 ! glutamate biosynthetic process
created_by: paola
creation_date: 2011-05-24T04:30:38Z

[Term]
id: GO:0097055
name: agmatine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of agmatine ((4-aminobutyl)guanidine, NH2-CH2-CH2-CH2-CH2-NH-C(-NH2)(=NH)). Agmatine is the decarboxylation product of the amino acid arginine and is an intermediate in polyamine biosynthesis. It is synthesized in the brain, stored in synaptic vesicles, accumulated by uptake, released by membrane depolarization, and inactivated by agmatinase." [CHEBI:17431, GOC:pr, GOC:yaf]
synonym: "agmatine anabolism" EXACT []
synonym: "agmatine biosynthesis" EXACT []
synonym: "agmatine formation" EXACT []
synonym: "agmatine synthesis" EXACT []
xref: Reactome:REACT_106428 "Agmatine biosynthesis, Gallus gallus"
xref: Reactome:REACT_115241 "Agmatine biosynthesis, Drosophila melanogaster"
xref: Reactome:REACT_14800 "Agmatine biosynthesis, Homo sapiens"
xref: Reactome:REACT_31718 "Agmatine biosynthesis, Escherichia coli"
xref: Reactome:REACT_32247 "Agmatine biosynthesis, Saccharomyces cerevisiae"
xref: Reactome:REACT_33455 "Agmatine biosynthesis, Staphylococcus aureus N315"
xref: Reactome:REACT_43083 "Agmatine biosynthesis, Canis familiaris"
xref: Reactome:REACT_77181 "Agmatine biosynthesis, Sus scrofa"
xref: Reactome:REACT_77791 "Agmatine biosynthesis, Mus musculus"
xref: Reactome:REACT_78113 "Agmatine biosynthesis, Dictyostelium discoideum"
xref: Reactome:REACT_84718 "Agmatine biosynthesis, Rattus norvegicus"
xref: Reactome:REACT_88428 "Agmatine biosynthesis, Bos taurus"
xref: Reactome:REACT_89325 "Agmatine biosynthesis, Schizosaccharomyces pombe"
xref: Reactome:REACT_90257 "Agmatine biosynthesis, Taeniopygia guttata"
xref: Reactome:REACT_92588 "Agmatine biosynthesis, Xenopus tropicalis"
xref: Reactome:REACT_93732 "Agmatine biosynthesis, Danio rerio"
is_a: GO:1901162 ! primary amino compound biosynthetic process
created_by: paola
creation_date: 2011-05-25T03:56:17Z

[Term]
id: GO:0097056
name: selenocysteinyl-tRNA(Sec) biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of selenocysteinyl-tRNA(Sec). This process occurs through the following steps: a unique serine-tRNA with a UGA recognizing anticodon is first aminoacylated with serine; this is then phosphorylated by phosphoseryl-tRNA[Ser]Sec kinase; lastly, selenium is swapped for the phosphate on the serine." [CHEBI:13166, GOC:yaf, PMID:15317934, UniPathway:UPA00906]
synonym: "selenocysteinyl-tRNA(Sec) anabolism" EXACT []
synonym: "selenocysteinyl-tRNA(Sec) biosynthesis" EXACT []
synonym: "selenocysteinyl-tRNA(Sec) formation" EXACT []
synonym: "selenocysteinyl-tRNA(Sec) synthesis" EXACT []
is_a: GO:0006399 ! tRNA metabolic process
is_a: GO:0032774 ! RNA biosynthetic process
created_by: paola
creation_date: 2011-05-25T05:33:19Z

[Term]
id: GO:0097057
name: TRAF2-GSTP1 complex
namespace: cellular_component
def: "A protein complex comprising tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and glutathione S-transferase pi 1 (GSTP1). This complex is thought to disrupt the TNF signaling cascade, thus down-regulating inflammatory responses." [GOC:BHF, PMID:16636664]
is_a: GO:0043234 ! protein complex
created_by: paola
creation_date: 2011-05-26T10:35:45Z

[Term]
id: GO:0097058
name: CRLF-CLCF1 complex
namespace: cellular_component
def: "A heterodimeric protein complex that is composed of cardiotrophin-like cytokine factor 1 (product of the CLCF1 gene) and cytokine receptor-like factor 1 (product of the CRLF gene) and is secreted into the extracellular space. The CRLF-CLCF1 complex is a ligand for the ciliary neurotrophic factor (CNTF) receptor complex." [GOC:BHF, PMID:10966616]
synonym: "CLF-CLC complex" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005615 ! extracellular space
created_by: paola
creation_date: 2011-05-26T10:37:55Z

[Term]
id: GO:0097059
name: CNTFR-CLCF1 complex
namespace: cellular_component
def: "A protein complex that is composed of two soluble ciliary neurotrophic factor receptor alpha subunits (product of the CNTFR gene) and two molecules of cardiotrophin-like cytokine factor 1 (product of the CLCF1 gene). The complex is secreted into the extracellular space." [GOC:BHF, PMID:11285233]
synonym: "sCNTFR-CLC complex" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005615 ! extracellular space
created_by: paola
creation_date: 2011-05-26T10:43:22Z

[Term]
id: GO:0097060
name: synaptic membrane
namespace: cellular_component
def: "A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." [GOC:BHF, PMID:20410104]
is_a: GO:0044456 ! synapse part
is_a: GO:0098590 ! plasma membrane region
intersection_of: GO:0098590 ! plasma membrane region
intersection_of: part_of GO:0045202 ! synapse
relationship: part_of GO:0045202 ! synapse
created_by: paola
creation_date: 2011-06-07T11:22:09Z

[Term]
id: GO:0097061
name: dendritic spine organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dendritic spine. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission." [GOC:BHF, PMID:20410104]
synonym: "dendritic spine organisation" EXACT []
is_a: GO:0030030 ! cell projection organization
created_by: paola
creation_date: 2011-06-07T11:26:53Z

[Term]
id: GO:0097062
name: dendritic spine maintenance
namespace: biological_process
def: "The organization process that preserves a dendritic spine in a stable functional or structural state. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission." [GOC:BHF, PMID:20410104]
is_a: GO:0043954 ! cellular component maintenance
is_a: GO:0097061 ! dendritic spine organization
created_by: paola
creation_date: 2011-06-07T11:29:03Z

[Term]
id: GO:0097063
name: cadmium ion sensor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with and responding, e.g. by conformational change, to changes in the cellular level of cadmium (Cd++)." [GOC:rs, PMID:19456862]
is_a: GO:0046870 ! cadmium ion binding
created_by: paola
creation_date: 2011-06-08T09:46:14Z

[Term]
id: GO:0097064
name: ncRNA export from nucleus
namespace: biological_process
def: "The directed movement of a non-coding RNA transcript (ncRNA) from the nucleus to the cytoplasm." [GOC:dgf, PMID:11352936]
synonym: "non-coding RNA export from nucleus" EXACT [GOC:pr]
is_a: GO:0006405 ! RNA export from nucleus
is_a: GO:1902582 ! single-organism intracellular transport
created_by: paola
creation_date: 2011-06-08T12:34:34Z

[Term]
id: GO:0097065
name: anterior head development
namespace: biological_process
def: "The process whose specific outcome is the progression of the anterior part of the head over time, from its formation to the mature structure." [GOC:yaf, PMID:14695376, PMID:15857913]
is_a: GO:0060322 ! head development
created_by: paola
creation_date: 2011-06-08T12:38:11Z

[Term]
id: GO:0097066
name: response to thyroid hormone
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus." [GOC:sjw, PMID:9916872]
synonym: "response to thyroid hormone stimulus" EXACT [GOC:dos]
is_a: GO:0009725 ! response to hormone
created_by: paola
creation_date: 2011-06-14T05:01:18Z

[Term]
id: GO:0097067
name: cellular response to thyroid hormone stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus." [GOC:sjw, PMID:9916872]
is_a: GO:0032870 ! cellular response to hormone stimulus
is_a: GO:0097066 ! response to thyroid hormone
created_by: paola
creation_date: 2011-06-14T05:02:47Z

[Term]
id: GO:0097068
name: response to thyroxine
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroxine stimulus." [GOC:sjw, PMID:9916872]
synonym: "response to T4" EXACT [Wikipedia:Thyroxine]
synonym: "response to T4 stimulus" EXACT [Wikipedia:Thyroxine]
synonym: "response to thyroxine stimulus" EXACT [GOC:dos]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0043200 ! response to amino acid
is_a: GO:0097066 ! response to thyroid hormone
is_a: GO:1904386 ! response to L-phenylalanine derivative
created_by: paola
creation_date: 2011-06-14T05:05:07Z

[Term]
id: GO:0097069
name: cellular response to thyroxine stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroxine stimulus." [GOC:sjw, PMID:9916872]
synonym: "cellular response to T4 stimulus" EXACT [Wikipedia:Thyroxine]
is_a: GO:0071230 ! cellular response to amino acid stimulus
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0097067 ! cellular response to thyroid hormone stimulus
is_a: GO:0097068 ! response to thyroxine
is_a: GO:1904387 ! cellular response to L-phenylalanine derivative
created_by: paola
creation_date: 2011-06-14T05:06:48Z

[Term]
id: GO:0097070
name: ductus arteriosus closure
namespace: biological_process
def: "The morphogenesis process in which the ductus arteriosus changes to no longer permit blood flow after birth. The ductus arteriosus is the shunt between the aorta and the pulmonary artery which allows blood to bypass the fetus' lungs." [GOC:hw]
is_a: GO:0048844 ! artery morphogenesis
created_by: paola
creation_date: 2011-06-15T04:00:46Z

[Term]
id: GO:0097071
name: interferon regulatory factor complex
namespace: cellular_component
def: "A protein complex that consists of two interferon regulatory proteins (IRFs); may be homodimeric or heterodimeric. The activation of a latent closed conformation of IRF in the cytoplasm is triggered by phosphorylation of Ser/Thr residues in a C-terminal region. Phosphorylation stimulates the C-terminal autoinhibitory domain to attain a highly extended conformation triggering dimerization through extensive contacts to a second subunit." [GOC:cna, PMID:20043992]
synonym: "IRF complex" EXACT []
is_a: GO:0043234 ! protein complex
created_by: paola
creation_date: 2011-06-15T04:22:30Z

[Term]
id: GO:0097072
name: interferon regulatory factor 3 complex
namespace: cellular_component
def: "An interferon regulatory factor complex that consists of a homodimer of interferon regulatory factor 3." [GOC:cna, PMID:12855817, PMID:14556004, Reactome:REACT_7146]
synonym: "IRF3:IRF3 complex" EXACT []
is_a: GO:0097071 ! interferon regulatory factor complex
created_by: paola
creation_date: 2011-06-15T04:26:10Z

[Term]
id: GO:0097073
name: interferon regulatory factor 5 complex
namespace: cellular_component
def: "An interferon regulatory factor complex that consists of a homodimer of interferon regulatory factor 5." [GOC:cna, PMID:12138184, PMID:16751392]
synonym: "IRF5:IRF5 complex" EXACT []
is_a: GO:0097071 ! interferon regulatory factor complex
created_by: paola
creation_date: 2011-06-15T04:28:57Z

[Term]
id: GO:0097074
name: interferon regulatory factor 7 complex
namespace: cellular_component
def: "An interferon regulatory factor complex that consists of a homodimer of interferon regulatory factor 7." [GOC:cna, PMID:18068231, Reactome:REACT_21965]
synonym: "IRF7:IRF7 complex" EXACT []
is_a: GO:0097071 ! interferon regulatory factor complex
created_by: paola
creation_date: 2011-06-15T04:31:04Z

[Term]
id: GO:0097075
name: interferon regulatory factor 3-interferon regulatory factor 7 complex
namespace: cellular_component
def: "An interferon regulatory factor complex that consists of a heterodimer of interferon regulatory factor 3 and interferon regulatory factor 7." [GOC:cna, PMID:18068231, Reactome:REACT_26957]
synonym: "IRF3:IRF7 complex" EXACT []
is_a: GO:0097071 ! interferon regulatory factor complex
created_by: paola
creation_date: 2011-06-15T04:33:36Z

[Term]
id: GO:0097076
name: transforming growth factor beta activated kinase 1 complex
namespace: cellular_component
def: "A protein complex that possesses protein kinase activity and activates the I-kappa B kinase complex (IKK) and mitogen-activated protein (MAP) kinases in response to TRAF6 signaling. It comprises the catalytic subunit TAK1 complexed to the regulatory subunits, termed TABs (TAK1-binding subunits)." [GOC:cna, PMID:16410796, PMID:17496917, PMID:18021073]
synonym: "TAK1 kinase complex" EXACT []
is_a: GO:0043234 ! protein complex
created_by: paola
creation_date: 2011-06-15T04:55:32Z

[Term]
id: GO:0097077
name: copper ion sensor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with and responding, e.g. by conformational change, to changes in the cellular level of copper(I) (Cu+)." [GOC:rs, PMID:19928961]
is_a: GO:0005507 ! copper ion binding
created_by: paola
creation_date: 2011-06-17T09:57:11Z

[Term]
id: GO:0097078
name: FAL1-SGD1 complex
namespace: cellular_component
def: "A protein complex involved in the 18S rRNA biogenesis. In S. cerevisiae this complex consists of Fal1p and Sgd1p and in humans this complex consists of NOM1 and eIF4AIII subunits." [GOC:rb, PMID:21576267]
is_a: GO:0043234 ! protein complex
created_by: paola
creation_date: 2011-06-17T09:59:10Z

[Term]
id: GO:0097079
name: selenite:proton symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: selenite(out) + H+(out) = selenite(in) + H+(in)." [GOC:mcc, PMID:20861301]
synonym: "selenite:H+ symporter activity" EXACT []
synonym: "selenite:hydrogen symporter activity" EXACT []
is_a: GO:0008509 ! anion transmembrane transporter activity
is_a: GO:0015295 ! solute:proton symporter activity
created_by: paola
creation_date: 2011-06-17T10:01:11Z

[Term]
id: GO:0097080
name: plasma membrane selenite transport
namespace: biological_process
def: "The directed movement of inorganic selenite (HSeO3-1 at physiological pH) across a plasma membrane." [GOC:mcc, PMID:20861301]
synonym: "plasma membrane hydrogenselenite transport" EXACT []
is_a: GO:0098656 ! anion transmembrane transport
created_by: paola
creation_date: 2011-06-17T10:03:55Z

[Term]
id: GO:0097081
name: vascular smooth muscle cell fate commitment
namespace: biological_process
def: "The commitment of cells to a vascular smooth muscle cell fate and their capacity to differentiate into vascular smooth muscle cells. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels." [GOC:BHF]
is_a: GO:0042693 ! muscle cell fate commitment
relationship: part_of GO:0035886 ! vascular smooth muscle cell differentiation
created_by: paola
creation_date: 2011-06-20T03:51:52Z

[Term]
id: GO:0097082
name: vascular smooth muscle cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a vascular smooth muscle cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels." [GOC:BHF]
is_a: GO:0042694 ! muscle cell fate specification
relationship: part_of GO:0097081 ! vascular smooth muscle cell fate commitment
created_by: paola
creation_date: 2011-06-20T03:56:21Z

[Term]
id: GO:0097083
name: vascular smooth muscle cell fate determination
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a vascular smooth muscle cell regardless of its environment; upon determination, the cell fate cannot be reversed. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels." [GOC:BHF]
is_a: GO:0007521 ! muscle cell fate determination
relationship: part_of GO:0097081 ! vascular smooth muscle cell fate commitment
created_by: paola
creation_date: 2011-06-20T04:00:28Z

[Term]
id: GO:0097084
name: vascular smooth muscle cell development
namespace: biological_process
def: "The process aimed at the progression of a vascular smooth muscle cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels." [GOC:BHF]
is_a: GO:0055001 ! muscle cell development
relationship: part_of GO:0035886 ! vascular smooth muscle cell differentiation
created_by: paola
creation_date: 2011-06-20T04:03:08Z

[Term]
id: GO:0097085
name: interferon regulatory factor 3-interferon regulatory factor 5 complex
namespace: cellular_component
def: "An interferon regulatory factor complex that consists of a heterodimer of interferon regulatory factor 3 and interferon regulatory factor 5." [GOC:cna, PMID:12138184]
synonym: "IRF3:IRF5 complex" EXACT []
is_a: GO:0097071 ! interferon regulatory factor complex
created_by: paola
creation_date: 2011-06-21T06:30:30Z

[Term]
id: GO:0097086
name: amniotic stem cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of an amniotic stem cell. An amniotic stem cell is a mesenchymal stem cell extracted from amniotic fluid. Amniotic stem cells are able to differentiate into various tissue types such as skin, cartilage, cardiac tissue, nerves, muscle, and bone." [CL:0002639, GOC:yaf, PMID:20942606, Wikipedia:Amniotic_stem_cells]
is_a: GO:0048762 ! mesenchymal cell differentiation
is_a: GO:0072497 ! mesenchymal stem cell differentiation
created_by: paola
creation_date: 2011-06-22T11:17:52Z

[Term]
id: GO:0097087
name: interleukin-17A production
namespace: biological_process
def: "The appearance of interleukin-17A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv, PR:000001138, Wikipedia:Interleukin_17]
synonym: "IL-17A production" EXACT []
is_a: GO:0032620 ! interleukin-17 production
created_by: paola
creation_date: 2011-06-23T11:31:10Z

[Term]
id: GO:0097088
name: interleukin-17F production
namespace: biological_process
def: "The appearance of interleukin-17F due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv, PR:000001142, Wikipedia:Interleukin_17]
synonym: "IL-17F production" EXACT []
is_a: GO:0032620 ! interleukin-17 production
created_by: paola
creation_date: 2011-06-23T11:32:59Z

[Term]
id: GO:0097089
name: methyl-branched fatty acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving methyl-branched fatty acids, aliphatic monocarboxylic acids with methyl branches on the main chain." [CHEBI:62499, GOC:rs, PMID:19933331]
synonym: "methyl-branched fatty acid metabolism" EXACT []
is_a: GO:0006631 ! fatty acid metabolic process
created_by: paola
creation_date: 2011-07-01T01:06:15Z

[Term]
id: GO:0097090
name: presynaptic membrane organization
namespace: biological_process
def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of a presynaptic membrane, including any proteins associated with the membrane, but excluding other cellular components. A presynaptic membrane is a specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction." [GOC:BHF, GOC:pr, GOC:sjp, PMID:19730411]
comment: Note that 'presynaptic membrane' in this term should not be mistaken with 'presynaptic active zone'. The latter encompasses more than the former, as it also includes the specialized cortical cytoskeletal matrix in the cell cortex of a presynaptic neuron.
synonym: "pre-synaptic membrane organization" EXACT []
synonym: "presynaptic membrane organisation" EXACT []
is_a: GO:0044802 ! single-organism membrane organization
relationship: part_of GO:0050808 ! synapse organization
created_by: paola
creation_date: 2011-07-04T01:45:30Z

[Term]
id: GO:0097091
name: synaptic vesicle clustering
namespace: biological_process
def: "The process that results in grouping synaptic vesicles, prior to release, at a specialized patch of the presynaptic membrane referred to as the active zone." [GOC:ans, GOC:pr, PMID:19900895]
subset: goslim_synapse
is_a: GO:0097479 ! synaptic vesicle localization
is_a: GO:1902580 ! single-organism cellular localization
relationship: part_of GO:0099504 ! synaptic vesicle cycle
created_by: paola
creation_date: 2011-07-04T01:48:24Z

[Term]
id: GO:0097092
name: polyacyltrehalose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving polyacyltrehalose, a pentaacylated, trehalose-based glycolipid." [CHEBI:62547, GOC:rs, PMID:19729090]
synonym: "polyacyltrehalose metabolism" EXACT []
is_a: GO:0006664 ! glycolipid metabolic process
created_by: paola
creation_date: 2011-07-05T01:58:28Z

[Term]
id: GO:0097093
name: polyacyltrehalose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of polyacyltrehalose, a pentaacylated, trehalose-based glycolipid." [CHEBI:62547, GOC:rs, PMID:19729090]
synonym: "polyacyltrehalose anabolism" EXACT []
synonym: "polyacyltrehalose biosynthesis" EXACT []
synonym: "polyacyltrehalose formation" EXACT []
synonym: "polyacyltrehalose synthesis" EXACT []
is_a: GO:0009247 ! glycolipid biosynthetic process
is_a: GO:0097092 ! polyacyltrehalose metabolic process
created_by: paola
creation_date: 2011-07-05T02:01:08Z

[Term]
id: GO:0097094
name: craniofacial suture morphogenesis
namespace: biological_process
def: "The process in which any suture between cranial and/or facial bones is generated and organized." [GOC:pr, GOC:sl, Wikipedia:Cranial_sutures, Wikipedia:Head_and_neck_anatomy#Musculoskeletal_system]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0044767 ! single-organism developmental process
relationship: part_of GO:0060349 ! bone morphogenesis
relationship: part_of GO:1904888 ! cranial skeletal system development
created_by: paola
creation_date: 2011-07-05T02:51:54Z

[Term]
id: GO:0097095
name: frontonasal suture morphogenesis
namespace: biological_process
def: "The process in which the frontonasal suture, between frontal and nasal bones, is generated and organized." [GOC:pr, GOC:sl, PMID:12416537, Wikipedia:Cranial_sutures, Wikipedia:Head_and_neck_anatomy#Musculoskeletal_system]
synonym: "nasofrontal suture morphogenesis" EXACT []
is_a: GO:0097094 ! craniofacial suture morphogenesis
created_by: paola
creation_date: 2011-07-05T02:57:46Z

[Term]
id: GO:0097096
name: facial suture morphogenesis
namespace: biological_process
def: "The process in which any suture between facial bones is generated and organized." [GOC:pr, GOC:sl, Wikipedia:Cranial_sutures, Wikipedia:Head_and_neck_anatomy#Musculoskeletal_system]
is_a: GO:0097094 ! craniofacial suture morphogenesis
created_by: paola
creation_date: 2011-07-05T03:06:27Z

[Term]
id: GO:0097097
name: nasal suture morphogenesis
namespace: biological_process
def: "The process in which the nasal suture is generated and organized." [GOC:pr, GOC:sl, Wikipedia:Cranial_sutures, Wikipedia:Head_and_neck_anatomy#Musculoskeletal_system]
synonym: "internasal suture morphogenesis" EXACT []
is_a: GO:0097096 ! facial suture morphogenesis
created_by: paola
creation_date: 2011-07-05T03:09:04Z

[Term]
id: GO:0097098
name: DNA/RNA hybrid annealing activity
namespace: molecular_function
def: "Facilitates the base-pairing of single-stranded RNA to double-stranded DNA resulting in the formation of R-loops." [GOC:imk, PMID:21699496]
is_a: GO:0071667 ! DNA/RNA hybrid binding
is_a: GO:0097617 ! annealing activity
created_by: paola
creation_date: 2011-07-07T11:20:44Z

[Term]
id: GO:0097099
name: structural constituent of albumen
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of albumen (also called egg white). Albumen is the clear liquid contained within an egg and consists of water and proteins, among which are ovomucin and ovomucoid. It protects the egg yolk and provides additional nutrition for the growth of the embryo." [GOC:jj, Wikipedia:Albumen]
synonym: "structural constituent of egg white" EXACT []
is_a: GO:0005198 ! structural molecule activity
created_by: paola
creation_date: 2011-07-07T02:12:51Z

[Term]
id: GO:0097100
name: supercoiled DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with supercoiled DNA. For example, during replication and transcription, template DNA is negatively supercoiled in the receding downstream DNA and positively supercoiled in the approaching downstream DNA." [GOC:pr, GOC:rph, PMID:20723754, PMID:21345933, Wikipedia:DNA_supercoil]
is_a: GO:0043566 ! structure-specific DNA binding
created_by: paola
creation_date: 2011-07-12T03:28:57Z

[Term]
id: GO:0097101
name: blood vessel endothelial cell fate specification
namespace: biological_process
def: "The process involved in the specification of identity of a blood vessel endothelial cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. A blood vessel endothelial cell is an endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels." [CL:0002139, GOC:dgh, PMID:21521739]
is_a: GO:0060847 ! endothelial cell fate specification
relationship: part_of GO:0060846 ! blood vessel endothelial cell fate commitment
created_by: paola
creation_date: 2011-07-27T10:24:32Z

[Term]
id: GO:0097102
name: endothelial tip cell fate specification
namespace: biological_process
def: "The process involved in the specification of identity of an endothelial tip cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. An endothelial tip cell is a specialized endothelial cell localized to the leading edge of an angiogenic sprout that senses extracellular signals and guides the directed growth of blood vessels." [CL:0000704, GOC:dgh, PMID:21521739]
synonym: "angiogenic tip cell fate specification" EXACT []
is_a: GO:0097101 ! blood vessel endothelial cell fate specification
relationship: part_of GO:0002040 ! sprouting angiogenesis
created_by: paola
creation_date: 2011-07-27T10:29:00Z

[Term]
id: GO:0097103
name: endothelial stalk cell fate specification
namespace: biological_process
def: "The process involved in the specification of identity of an endothelial stalk cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. An endothelial stalk cell is a specialized endothelial cell which follows behind the tip cell of an angiogenic sprout." [CL:0002671, GOC:dgh, PMID:21521739]
synonym: "angiogenic stalk cell fate specification" EXACT []
is_a: GO:0097101 ! blood vessel endothelial cell fate specification
relationship: part_of GO:0002040 ! sprouting angiogenesis
created_by: paola
creation_date: 2011-07-27T10:32:38Z

[Term]
id: GO:0097104
name: postsynaptic membrane assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a postsynaptic membrane, a specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft)." [GOC:BHF, GOC:sjp, PMID:21424692]
subset: goslim_synapse
synonym: "post-synaptic membrane assembly" EXACT []
is_a: GO:0001941 ! postsynaptic membrane organization
is_a: GO:0071709 ! membrane assembly
relationship: part_of GO:0007416 ! synapse assembly
created_by: paola
creation_date: 2011-07-27T01:26:49Z

[Term]
id: GO:0097105
name: presynaptic membrane assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a presynaptic membrane, including any proteins associated with the membrane, but excluding other cellular components. A presynaptic membrane is a  specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction." [GOC:BHF, GOC:pr, GOC:sjp, PMID:15797875, PMID:18550748]
comment: Note that 'presynaptic membrane' in this term should not be mistaken with 'presynaptic active zone'. The latter encompasses more than the former, as it also includes the specialized cortical cytoskeletal matrix in the cell cortex of a presynaptic neuron.
subset: goslim_synapse
synonym: "pre-synaptic membrane assembly" EXACT []
is_a: GO:0071709 ! membrane assembly
is_a: GO:0097090 ! presynaptic membrane organization
relationship: part_of GO:0007416 ! synapse assembly
created_by: paola
creation_date: 2011-07-27T01:30:45Z

[Term]
id: GO:0097106
name: postsynaptic density organization
namespace: biological_process
def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic density, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse." [GOC:BHF, GOC:sjp, PMID:21525273]
synonym: "post synaptic density organization" EXACT []
synonym: "post-synaptic density organization" EXACT []
synonym: "postsynaptic density organisation" EXACT []
synonym: "PSD organization" EXACT []
is_a: GO:1902589 ! single-organism organelle organization
relationship: part_of GO:0050808 ! synapse organization
created_by: paola
creation_date: 2011-07-27T05:17:12Z

[Term]
id: GO:0097107
name: postsynaptic density assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a postsynaptic density, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse." [GOC:BHF, GOC:sjp, PMID:21525273]
subset: goslim_synapse
synonym: "post synaptic density assembly" EXACT []
synonym: "post-synaptic density assembly" EXACT []
synonym: "PSD assembly" EXACT []
is_a: GO:0070925 ! organelle assembly
is_a: GO:0097106 ! postsynaptic density organization
relationship: part_of GO:1904861 ! excitatory synapse assembly
created_by: paola
creation_date: 2011-07-27T05:21:39Z

[Term]
id: GO:0097108
name: hedgehog family protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a member of the hedgehog protein family, signaling proteins involved in development." [GOC:BHF, GOC:pr, PMID:10050855]
is_a: GO:0005515 ! protein binding
created_by: paola
creation_date: 2011-07-28T10:06:45Z

[Term]
id: GO:0097109
name: neuroligin family protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a member of the neuroligin protein family, neuronal cell surface proteins that mediate synapse formation." [GOC:BHF, GOC:pr, GOC:sjp, PMID:21424692]
is_a: GO:0005102 ! receptor binding
created_by: paola
creation_date: 2011-07-28T05:15:22Z

[Term]
id: GO:0097110
name: scaffold protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes." [GOC:BHF, GOC:sjp, PMID:10433269, Wikipedia:Scaffold_protein]
is_a: GO:0005515 ! protein binding
created_by: paola
creation_date: 2011-07-28T05:16:53Z

[Term]
id: GO:0097111
name: endoplasmic reticulum-Golgi intermediate compartment organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER)-Golgi intermediate compartment." [GOC:br, PMID:18287528]
synonym: "endoplasmic reticulum-Golgi intermediate compartment organisation" EXACT []
synonym: "endoplasmic reticulum-Golgi intermediate compartment organization and biogenesis" RELATED []
synonym: "ER-Golgi intermediate compartment organization" EXACT []
synonym: "ERGIC organization" EXACT []
is_a: GO:0006996 ! organelle organization
created_by: paola
creation_date: 2011-07-29T04:45:54Z

[Term]
id: GO:0097112
name: gamma-aminobutyric acid receptor clustering
namespace: biological_process
def: "The receptor clustering process in which gamma-aminobutyric acid (GABA) receptors are localized to distinct domains in the cell membrane." [GOC:BHF, GOC:sjp, PMID:15620359]
synonym: "GABA receptor clustering" EXACT []
is_a: GO:0072578 ! neurotransmitter-gated ion channel clustering
relationship: part_of GO:0001941 ! postsynaptic membrane organization
created_by: paola
creation_date: 2011-07-31T05:21:08Z

[Term]
id: GO:0097113
name: AMPA glutamate receptor clustering
namespace: biological_process
def: "The glutamate receptor clustering process in which alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors are localized to distinct domains in the cell membrane." [GOC:BHF, GOC:pr, GOC:sjp, PMID:12796785]
synonym: "alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering" EXACT []
synonym: "AMPA receptor clustering" EXACT []
is_a: GO:0097688 ! glutamate receptor clustering
relationship: part_of GO:0001941 ! postsynaptic membrane organization
created_by: paola
creation_date: 2011-07-31T05:25:53Z

[Term]
id: GO:0097114
name: NMDA glutamate receptor clustering
namespace: biological_process
def: "The receptor clustering process in which N-methyl-D-aspartate (NMDA) receptors are localized to distinct domains in the cell membrane." [GOC:BHF, GOC:sjp, PMID:15620359]
synonym: "N-methyl-D-aspartate receptor clustering" EXACT []
synonym: "NMDA receptor clustering" EXACT []
is_a: GO:0072578 ! neurotransmitter-gated ion channel clustering
relationship: part_of GO:0001941 ! postsynaptic membrane organization
created_by: paola
creation_date: 2011-07-31T05:30:15Z

[Term]
id: GO:0097115
name: neurexin clustering involved in presynaptic membrane assembly
namespace: biological_process
def: "The receptor clustering process involved in assembly of the presynaptic membrane in which neurexins are localized to distinct domains in the cell membrane. Neurexins are synaptic cell surface proteins which act as cell recognition molecules at nerve terminals." [GOC:BHF, GOC:sjp, PMID:12796785]
synonym: "neurexin clustering" BROAD []
synonym: "Nrxn clustering" BROAD []
synonym: "presynaptic neurexin clustering" EXACT []
is_a: GO:0043113 ! receptor clustering
intersection_of: GO:0043113 ! receptor clustering
intersection_of: part_of GO:0097105 ! presynaptic membrane assembly
relationship: part_of GO:0097105 ! presynaptic membrane assembly
created_by: paola
creation_date: 2011-07-31T05:40:00Z

[Term]
id: GO:0097116
name: gephyrin clustering involved in postsynaptic density assembly
namespace: biological_process
def: "The clustering process in which gephyrin molecules are localized to distinct domains in the postsynaptic density as part of postsynaptic density assembly. Gephyrin is a component of the postsynaptic protein network of inhibitory synapses." [GOC:BHF, GOC:sjp, PMID:15620359, PMID:24552784, PMID:25772192]
synonym: "Geph clustering" BROAD []
is_a: GO:0035418 ! protein localization to synapse
intersection_of: GO:0035418 ! protein localization to synapse
intersection_of: part_of GO:0097107 ! postsynaptic density assembly
relationship: part_of GO:0097107 ! postsynaptic density assembly
created_by: paola
creation_date: 2011-07-31T05:42:29Z

[Term]
id: GO:0097117
name: guanylate kinase-associated protein clustering
namespace: biological_process
def: "The clustering process in which guanylate kinase-associated proteins (GKAPs) are localized to distinct domains in the cell membrane. GKAP facilitates assembly of the post synaptic density of neurons." [GOC:BHF, GOC:sjp, PMID:15620359]
synonym: "GKAP clustering" EXACT []
is_a: GO:0072657 ! protein localization to membrane
relationship: part_of GO:0001941 ! postsynaptic membrane organization
created_by: paola
creation_date: 2011-07-31T05:44:35Z

[Term]
id: GO:0097118
name: neuroligin clustering involved in postsynaptic membrane assembly
namespace: biological_process
def: "The receptor clustering process involved in assembly of the postsynaptic membrane in which neuroligins are localized to distinct domains in the cell membrane. Neuroligins are neuronal cell surface proteins on the postsynaptic membrane that mediate synapse formation between neurons." [GOC:BHF, GOC:sjp, PMID:12796785]
synonym: "neuroligin clustering" BROAD []
synonym: "Nlgn clustering" BROAD []
synonym: "postsynaptic neuroligin clustering" EXACT []
is_a: GO:0043113 ! receptor clustering
intersection_of: GO:0043113 ! receptor clustering
intersection_of: part_of GO:0097104 ! postsynaptic membrane assembly
relationship: part_of GO:0097104 ! postsynaptic membrane assembly
created_by: paola
creation_date: 2011-07-31T05:47:25Z

[Term]
id: GO:0097119
name: postsynaptic density protein 95 clustering
namespace: biological_process
def: "The clustering process in which postsynaptic density protein 95 (PSD-95) molecules are localized to distinct domains in the cell membrane. PSD-95 is mostly located in the post synaptic density of neurons, and is involved in anchoring synaptic proteins." [GOC:BHF, GOC:sjp, PMID:10433269]
synonym: "Dlg4 clustering" EXACT []
synonym: "post-synaptic density protein 95 clustering" EXACT []
synonym: "PSD-95 clustering" EXACT []
is_a: GO:0072657 ! protein localization to membrane
relationship: part_of GO:0001941 ! postsynaptic membrane organization
created_by: paola
creation_date: 2011-07-31T05:49:44Z

[Term]
id: GO:0097120
name: receptor localization to synapse
namespace: biological_process
def: "Any process in which a receptor is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." [GOC:BHF, GOC:sjp, PMID:21525273]
synonym: "receptor localisation to synapse" EXACT []
is_a: GO:0035418 ! protein localization to synapse
created_by: paola
creation_date: 2011-07-31T09:20:30Z

[Term]
id: GO:0097121
name: cyclin A1-CDK1 complex
namespace: cellular_component
def: "A protein complex consisting of cyclin A1 and cyclin-dependent kinase 1 (CDK1). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619]
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex
created_by: paola
creation_date: 2011-08-01T01:41:25Z

[Term]
id: GO:0097122
name: cyclin A2-CDK1 complex
namespace: cellular_component
def: "A protein complex consisting of cyclin A2 and cyclin-dependent kinase 1 (CDK1). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619]
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex
created_by: paola
creation_date: 2011-08-01T01:42:24Z

[Term]
id: GO:0097123
name: cyclin A1-CDK2 complex
namespace: cellular_component
def: "A protein complex consisting of cyclin A1 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619]
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex
created_by: paola
creation_date: 2011-08-01T01:43:18Z

[Term]
id: GO:0097124
name: cyclin A2-CDK2 complex
namespace: cellular_component
def: "A protein complex consisting of cyclin A2 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619]
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex
created_by: paola
creation_date: 2011-08-01T01:44:19Z

[Term]
id: GO:0097125
name: cyclin B1-CDK1 complex
namespace: cellular_component
def: "A protein complex consisting of cyclin B1 and cyclin-dependent kinase 1 (CDK1). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619]
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex
created_by: paola
creation_date: 2011-08-01T01:45:15Z

[Term]
id: GO:0097126
name: cyclin B2-CDK1 complex
namespace: cellular_component
def: "A protein complex consisting of cyclin B2 and cyclin-dependent kinase 1 (CDK1). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619]
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex
created_by: paola
creation_date: 2011-08-01T01:46:17Z

[Term]
id: GO:0097127
name: cyclin B3-CDK2 complex
namespace: cellular_component
def: "A protein complex consisting of cyclin B3 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619]
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex
created_by: paola
creation_date: 2011-08-01T01:47:16Z

[Term]
id: GO:0097128
name: cyclin D1-CDK4 complex
namespace: cellular_component
def: "A protein complex consisting of cyclin D1 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619, PR:000026740]
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex
created_by: paola
creation_date: 2011-08-01T01:48:36Z

[Term]
id: GO:0097129
name: cyclin D2-CDK4 complex
namespace: cellular_component
def: "A protein complex consisting of cyclin D2 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619]
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex
created_by: paola
creation_date: 2011-08-01T01:53:15Z

[Term]
id: GO:0097130
name: cyclin D3-CDK4 complex
namespace: cellular_component
def: "A protein complex consisting of cyclin D3 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619]
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex
created_by: paola
creation_date: 2011-08-01T01:54:17Z

[Term]
id: GO:0097131
name: cyclin D1-CDK6 complex
namespace: cellular_component
def: "A protein complex consisting of cyclin D1 and cyclin-dependent kinase 6 (CDK6). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619]
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex
created_by: paola
creation_date: 2011-08-01T01:55:26Z

[Term]
id: GO:0097132
name: cyclin D2-CDK6 complex
namespace: cellular_component
def: "A protein complex consisting of cyclin D2 and cyclin-dependent kinase 6 (CDK6). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619]
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex
created_by: paola
creation_date: 2011-08-01T01:56:34Z

[Term]
id: GO:0097133
name: cyclin D3-CDK6 complex
namespace: cellular_component
def: "A protein complex consisting of cyclin D3 and cyclin-dependent kinase 6 (CDK6). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619]
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex
created_by: paola
creation_date: 2011-08-01T01:57:41Z

[Term]
id: GO:0097134
name: cyclin E1-CDK2 complex
namespace: cellular_component
def: "A protein complex consisting of cyclin E1 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619, PR:000026745]
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex
created_by: paola
creation_date: 2011-08-01T01:58:42Z

[Term]
id: GO:0097135
name: cyclin E2-CDK2 complex
namespace: cellular_component
def: "A protein complex consisting of cyclin E2 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619, PR:000026746]
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex
created_by: paola
creation_date: 2011-08-01T01:59:57Z

[Term]
id: GO:0097136
name: Bcl-2 family protein complex
namespace: cellular_component
def: "A protein complex that consists of members of the Bcl-2 family of anti- and proapoptotic regulators. Bcl-2 proteins respond to cues from various forms of intracellular stress, such as DNA damage or cytokine deprivation, and interact with opposing family members to determine whether or not the caspase proteolytic cascade should be unleashed." [GOC:so, PMID:14634621]
is_a: GO:0043234 ! protein complex
created_by: paola
creation_date: 2011-08-02T01:34:19Z

[Term]
id: GO:0097137
name: BAD-BCL-xl complex
namespace: cellular_component
def: "A heterodimeric protein complex consisting of BAD and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:so, PMID:14634621]
is_a: GO:0097136 ! Bcl-2 family protein complex
created_by: paola
creation_date: 2011-08-02T01:36:06Z

[Term]
id: GO:0097138
name: BAD-BCL-2 complex
namespace: cellular_component
def: "A heterodimeric protein complex consisting of BAD and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:so, PMID:14634621]
is_a: GO:0097136 ! Bcl-2 family protein complex
created_by: paola
creation_date: 2011-08-02T01:37:50Z

[Term]
id: GO:0097139
name: BID-BCL-2 complex
namespace: cellular_component
def: "A heterodimeric protein complex consisting of BID and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:so, PMID:14634621]
is_a: GO:0097136 ! Bcl-2 family protein complex
created_by: paola
creation_date: 2011-08-02T01:40:31Z

[Term]
id: GO:0097140
name: BIM-BCL-xl complex
namespace: cellular_component
def: "A heterodimeric protein complex consisting of BIM and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:so, PMID:14634621]
is_a: GO:0097136 ! Bcl-2 family protein complex
created_by: paola
creation_date: 2011-08-02T01:41:30Z

[Term]
id: GO:0097141
name: BIM-BCL-2 complex
namespace: cellular_component
def: "A heterodimeric protein complex consisting of BIM and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:so, PMID:14634621]
is_a: GO:0097136 ! Bcl-2 family protein complex
created_by: paola
creation_date: 2011-08-02T01:42:31Z

[Term]
id: GO:0097142
name: PUMA-BCL-2 complex
namespace: cellular_component
def: "A heterodimeric protein complex consisting of PUMA and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:so, PMID:14634621]
is_a: GO:0097136 ! Bcl-2 family protein complex
created_by: paola
creation_date: 2011-08-02T01:43:18Z

[Term]
id: GO:0097143
name: PUMA-BCL-xl complex
namespace: cellular_component
def: "A heterodimeric protein complex consisting of PUMA and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:so, PMID:14634621]
is_a: GO:0097136 ! Bcl-2 family protein complex
created_by: paola
creation_date: 2011-08-02T01:44:10Z

[Term]
id: GO:0097144
name: BAX complex
namespace: cellular_component
def: "An oligomeric protein complex consisting of BAX, a member of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:so, PMID:14634621]
is_a: GO:0097136 ! Bcl-2 family protein complex
created_by: paola
creation_date: 2011-08-02T01:45:15Z

[Term]
id: GO:0097145
name: BAK complex
namespace: cellular_component
def: "An oligomeric protein complex consisting of BAK, a member of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:so, PMID:14634621]
is_a: GO:0097136 ! Bcl-2 family protein complex
created_by: paola
creation_date: 2011-08-02T01:48:11Z

[Term]
id: GO:0097146
name: NOXA-BCL-xl complex
namespace: cellular_component
def: "A heterodimeric protein complex consisting of NOXA and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:so, PMID:14634621]
is_a: GO:0097136 ! Bcl-2 family protein complex
created_by: paola
creation_date: 2011-08-02T01:49:00Z

[Term]
id: GO:0097147
name: NOXA-BCL-2 complex
namespace: cellular_component
def: "A heterodimeric protein complex consisting of NOXA and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:so, PMID:14634621]
is_a: GO:0097136 ! Bcl-2 family protein complex
created_by: paola
creation_date: 2011-08-02T01:50:14Z

[Term]
id: GO:0097148
name: BCL-2 complex
namespace: cellular_component
def: "A homodimeric protein complex consisting of BCL-2, a member of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:bhm, GOC:so, PMID:14634621]
is_a: GO:0097136 ! Bcl-2 family protein complex
created_by: paola
creation_date: 2011-08-02T01:51:16Z

[Term]
id: GO:0097149
name: centralspindlin complex
namespace: cellular_component
def: "A heterotetrameric protein complex playing a key role in the formation of the central spindle in mitosis. Made up of two molecules each of a mitotic kinesin (ZEN-4 in Caenorhabditis elegans or MKLP1 in mammals) and of two molecules each of a GTPase activating protein (GAP) factor (CYK-4 in Caenorhabditis elegans or MgcRacGAP in mammals)." [GOC:ans, PMID:11782313, PMID:16236794]
is_a: GO:0043234 ! protein complex
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0072686 ! mitotic spindle
created_by: paola
creation_date: 2011-08-04T11:15:37Z

[Term]
id: GO:0097150
name: neuronal stem cell population maintenance
namespace: biological_process
def: "Any process in by an organism or tissue maintains a population of neuronal stem cells." [CL:0000047, GOC:dos, GOC:yaf, PMID:11399758]
is_a: GO:0019827 ! stem cell population maintenance
created_by: paola
creation_date: 2011-08-04T11:18:28Z

[Term]
id: GO:0097151
name: positive regulation of inhibitory postsynaptic potential
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of inhibitory postsynaptic potential (IPSP). IPSP is a temporary decrease in postsynaptic membrane potential due to the flow of negatively charged ions into the postsynaptic cell. The flow of ions that causes an IPSP is an inhibitory postsynaptic current (IPSC) and makes it more difficult for the neuron to fire an action potential." [GOC:BHF, GOC:sjp, PMID:18550748]
synonym: "positive regulation of inhibitory post-synaptic membrane potential" EXACT []
synonym: "positive regulation of IPSP" EXACT []
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0050806 ! positive regulation of synaptic transmission
is_a: GO:0098828 ! modulation of inhibitory postsynaptic potential
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: positively_regulates GO:0060080 ! inhibitory postsynaptic potential
relationship: positively_regulates GO:0060080 ! inhibitory postsynaptic potential
created_by: paola
creation_date: 2011-08-12T10:07:45Z

[Term]
id: GO:0097152
name: mesenchymal cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types." [CL:0000134, GOC:mtg_apoptosis, GOC:yaf, PMID:18231833]
synonym: "mesenchymal cell apoptosis" NARROW []
is_a: GO:0006915 ! apoptotic process
created_by: paola
creation_date: 2011-09-06T02:31:59Z

[Term]
id: GO:0097153
name: cysteine-type endopeptidase activity involved in apoptotic process
namespace: molecular_function
def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic process." [GOC:mtg_apoptosis]
synonym: "caspase activity" BROAD []
synonym: "metacaspase activity" NARROW [GOC:mtg_apoptosis]
is_a: GO:0004197 ! cysteine-type endopeptidase activity
intersection_of: GO:0004197 ! cysteine-type endopeptidase activity
intersection_of: part_of GO:0006915 ! apoptotic process
relationship: part_of GO:0006915 ! apoptotic process
created_by: paola
creation_date: 2011-09-09T10:21:56Z

[Term]
id: GO:0097154
name: GABAergic neuron differentiation
namespace: biological_process
def: "The process in which a neuroblast acquires the specialized structural and functional features of a GABAergic neuron." [GOC:kmv, PMID:11517269]
is_a: GO:0030182 ! neuron differentiation
created_by: paola
creation_date: 2011-09-14T09:39:11Z

[Term]
id: GO:0097155
name: fasciculation of sensory neuron axon
namespace: biological_process
def: "The collection of sensory neuron axons into a bundle of rods, known as a fascicle." [GOC:lb, PMID:18403711]
is_a: GO:0007413 ! axonal fasciculation
created_by: paola
creation_date: 2011-09-16T09:17:34Z

[Term]
id: GO:0097156
name: fasciculation of motor neuron axon
namespace: biological_process
def: "The collection of motor neuron axons into a bundle of rods, known as a fascicle." [GOC:lb, PMID:18403711]
is_a: GO:0007413 ! axonal fasciculation
created_by: paola
creation_date: 2011-09-16T09:20:46Z

[Term]
id: GO:0097157
name: pre-mRNA intronic binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an intronic sequence of a pre-messenger RNA (pre-mRNA)." [GOC:ans, PMID:16260624]
synonym: "pre-messenger RNA intronic binding" EXACT []
is_a: GO:0036002 ! pre-mRNA binding
created_by: paola
creation_date: 2011-09-23T11:27:01Z

[Term]
id: GO:0097158
name: pre-mRNA intronic pyrimidine-rich binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a pyrimidine-rich (CU-rich) intronic sequence of a pre-messenger RNA (pre-mRNA)." [GOC:ans, PMID:16260624, PMID:16777844]
synonym: "pre-messenger RNA intronic pyrimidine-rich binding" EXACT []
is_a: GO:0097157 ! pre-mRNA intronic binding
created_by: paola
creation_date: 2011-09-23T11:29:03Z

[Term]
id: GO:0097159
name: organic cyclic compound binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure." [CHEBI:33832, GOC:sjw, PMID:7583672]
is_a: GO:0005488 ! binding
created_by: paola
creation_date: 2011-09-23T02:31:01Z

[Term]
id: GO:0097160
name: polychlorinated biphenyl binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a polychlorinated biphenyl (PCB), a biphenyl compound containing between 2 and 10 chlorine atoms attached to the two benzene rings." [CHEBI:53156, GOC:sjw, PMID:7583672]
synonym: "PCB binding" EXACT []
synonym: "polychlorobiphenyl binding" EXACT []
is_a: GO:0097159 ! organic cyclic compound binding
created_by: paola
creation_date: 2011-09-23T02:33:22Z

[Term]
id: GO:0097161
name: DH domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a DH (Dbl homology) domain of a protein. The DH domain contains three structurally conserved regions separated by more variable regions. It is composed of 11 alpha helices that are folded into a flattened, elongated alpha-helix bundle in which two of the three conserved regions, conserved region 1 (CR1) and conserved region 3 (CR3), are exposed near the centre of one surface. CR1 and CR3, together with a part of alpha-6 and the DH/PH (pleckstrin homology) junction site, constitute the Rho GTPase interacting pocket." [GOC:yaf, InterPro:IPR000219, PMID:12775584]
is_a: GO:0019904 ! protein domain specific binding
created_by: paola
creation_date: 2011-09-27T10:06:09Z

[Term]
id: GO:0097162
name: MADS box domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a MADS box domain, a protein domain that encodes the DNA-binding MADS domain. The MADS domain binds to DNA sequences of high similarity to the motif CC[A/T]6GG termed the CArG-box. MADS-domain proteins are generally transcription factors. The length of the MADS-box is in the range of 168 to 180 base pairs." [GOC:yaf, InterPro:IPR002100, PMID:18296735, Wikipedia:MADS-box]
is_a: GO:0019904 ! protein domain specific binding
created_by: paola
creation_date: 2011-09-27T10:10:59Z

[Term]
id: GO:0097163
name: sulfur carrier activity
namespace: molecular_function
def: "Enables the directed movement of sulfur into, out of or within a cell, or between cells." [GOC:imk, PMID:16387657]
is_a: GO:0022892 ! substrate-specific transporter activity
created_by: paola
creation_date: 2011-09-27T10:15:41Z

[Term]
id: GO:0097164
name: ammonium ion metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the ammonium ion." [CHEBI:35274, GOC:dhl, GOC:tb, PMID:14671018]
synonym: "ammonium ion metabolism" EXACT []
synonym: "ammonium metabolic process" RELATED []
is_a: GO:0006807 ! nitrogen compound metabolic process
created_by: paola
creation_date: 2011-09-28T04:21:30Z

[Term]
id: GO:0097165
name: nuclear stress granule
namespace: cellular_component
def: "A dense aggregation in the nucleus composed of proteins and RNAs that appear when the cell is under stress." [GOC:ans, PMID:10359787, PMID:12865437]
is_a: GO:0035770 ! ribonucleoprotein granule
is_a: GO:0044428 ! nuclear part
created_by: paola
creation_date: 2011-09-28T07:49:55Z

[Term]
id: GO:0097166
name: lens epithelial cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of lens epithelial cells, resulting in the expansion of a cell population. Lens epithelial cells make up the lens epithelium, which is located in the anterior portion of the lens between the lens capsule and the lens fibers and is a simple cuboidal epithelium. The epithelial cells of the lens regulate most of the homeostatic functions of the lens such as osmolarity and liquid volume. The lens epithelial cells also serve as the progenitors for new lens fibers. The lens epithelium constantly lays down fibers in the embryo, fetus, infant, and adult, and continues to lay down fibers for lifelong growth." [CL:0002224, GOC:yaf, PMID:18423449, Wikipedia:Lens_%28anatomy%29#Lens_epithelium]
is_a: GO:0050673 ! epithelial cell proliferation
relationship: part_of GO:0002088 ! lens development in camera-type eye
created_by: paola
creation_date: 2011-09-29T01:27:50Z

[Term]
id: GO:0097167
name: circadian regulation of translation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mRNA translation with a regularity of approximately 24 hours." [GOC:ans, PMID:17264215]
synonym: "regulation of mRNA translation in response to circadian clock" EXACT []
is_a: GO:0006417 ! regulation of translation
is_a: GO:0007623 ! circadian rhythm
is_a: GO:0044707 ! single-multicellular organism process
created_by: paola
creation_date: 2011-09-29T03:13:31Z

[Term]
id: GO:0097168
name: mesenchymal stem cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of mesenchymal stem cells, resulting in the expansion of a stem cell population. A mesenchymal stem cell, or MSC, is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [CL:0000134, GOC:yaf, PMID:20626275]
synonym: "MSC proliferation" EXACT []
is_a: GO:0072089 ! stem cell proliferation
created_by: paola
creation_date: 2011-09-29T04:44:48Z

[Term]
id: GO:0097169
name: AIM2 inflammasome complex
namespace: cellular_component
def: "A protein complex that consists of AIM2, ASC, and caspase-1. AIM2 is a member of the HN-200 protein family that appears to be the sensor of cytosolic double-stranded DNA." [GOC:vp, PMID:20303873]
is_a: GO:0061702 ! inflammasome complex
created_by: paola
creation_date: 2011-10-03T07:36:21Z

[Term]
id: GO:0097170
name: ADP-L-glycero-beta-D-manno-heptose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ADP-L-glycero-beta-D-manno-heptose, an ADP-L-glycero-D-manno-heptose having beta-configuration at the anomeric centre of the heptose. ADP-L-glycero-beta-D-manno-heptose (also called ADP-L-beta-D-heptose or ADP-L-glycero-D-manno-heptose) is a nucleotide-sugar precursor of the inner core lipopolysaccharide (LPS) from D-glycero-beta-D-manno-heptose 7-phosphate." [CHEBI:61530, GOC:yaf]
synonym: "ADP-L-glycero-beta-D-manno-heptose metabolism" EXACT []
is_a: GO:0009225 ! nucleotide-sugar metabolic process
created_by: paola
creation_date: 2011-10-03T09:12:58Z

[Term]
id: GO:0097171
name: ADP-L-glycero-beta-D-manno-heptose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ADP-L-glycero-beta-D-manno-heptose, an ADP-L-glycero-D-manno-heptose having beta-configuration at the anomeric centre of the heptose. ADP-L-glycero-beta-D-manno-heptose (also called ADP-L-beta-D-heptose or ADP-L-glycero-D-manno-heptose) is a nucleotide-sugar precursor of the inner core lipopolysaccharide (LPS) from D-glycero-beta-D-manno-heptose 7-phosphate." [CHEBI:61530, GOC:yaf, UniPathway:UPA00356]
synonym: "ADP-L-glycero-beta-D-manno-heptose anabolism" EXACT []
synonym: "ADP-L-glycero-beta-D-manno-heptose biosynthesis" EXACT []
synonym: "ADP-L-glycero-beta-D-manno-heptose formation" EXACT []
synonym: "ADP-L-glycero-beta-D-manno-heptose synthesis" EXACT []
is_a: GO:0009226 ! nucleotide-sugar biosynthetic process
is_a: GO:0097170 ! ADP-L-glycero-beta-D-manno-heptose metabolic process
created_by: paola
creation_date: 2011-10-03T09:15:03Z

[Term]
id: GO:0097172
name: N-acetylmuramic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving N-acetylmuramic acid (MurNAc), a monosaccharide derivative of N-acetylglucosamine." [CHEBI:47978, GOC:yaf, PubChem_Compound:5462244]
synonym: "N-acetylmuramate metabolic process" EXACT []
synonym: "N-acetylmuramate metabolism" EXACT []
synonym: "N-acetylmuramic acid metabolism" EXACT []
is_a: GO:0006040 ! amino sugar metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process
created_by: paola
creation_date: 2011-10-07T12:45:24Z

[Term]
id: GO:0097173
name: N-acetylmuramic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of N-acetylmuramic acid (MurNAc), a monosaccharide derivative of N-acetylglucosamine." [CHEBI:47978, GOC:yaf, PubChem_Compound:5462244, UniPathway:UPA00342]
synonym: "N-acetylmuramate breakdown" EXACT []
synonym: "N-acetylmuramate catabolic process" EXACT []
synonym: "N-acetylmuramate catabolism" EXACT []
synonym: "N-acetylmuramate degradation" EXACT []
synonym: "N-acetylmuramic acid breakdown" EXACT []
synonym: "N-acetylmuramic acid catabolism" EXACT []
synonym: "N-acetylmuramic acid degradation" EXACT []
is_a: GO:0046348 ! amino sugar catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process
is_a: GO:0097172 ! N-acetylmuramic acid metabolic process
created_by: paola
creation_date: 2011-10-07T12:48:47Z

[Term]
id: GO:0097174
name: 1,6-anhydro-N-acetyl-beta-muramic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 1,6-anhydro-N-acetyl-beta-muramic acid, the 1,6-anhydro-derivative of N-acetyl-beta-muramic acid." [CHEBI:58690, GOC:yaf, PMID:15901686]
synonym: "1,6-anhydro-N-acetyl-beta-muramate metabolic process" EXACT []
synonym: "1,6-anhydro-N-acetyl-beta-muramate metabolism" EXACT []
synonym: "1,6-anhydro-N-acetyl-beta-muramic acid metabolism" EXACT []
synonym: "1,6-anhydro-N-acetylmuramic acid metabolic process" EXACT []
synonym: "1,6-anhydro-N-acetylmuramic acid metabolism" EXACT []
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process
created_by: paola
creation_date: 2011-10-07T12:54:36Z

[Term]
id: GO:0097175
name: 1,6-anhydro-N-acetyl-beta-muramic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 1,6-anhydro-N-acetylmuramic acid, the 1,6-anhydro-derivative of N-acetyl-beta-muramic acid." [CHEBI:58690, GOC:yaf, PMID:15901686, UniPathway:UPA00343]
synonym: "1,6-anhydro-N-acetyl-beta-muramate breakdown" EXACT []
synonym: "1,6-anhydro-N-acetyl-beta-muramate catabolic process" EXACT []
synonym: "1,6-anhydro-N-acetyl-beta-muramate catabolism" EXACT []
synonym: "1,6-anhydro-N-acetyl-beta-muramate degradation" EXACT []
synonym: "1,6-anhydro-N-acetyl-beta-muramic acid breakdown" EXACT []
synonym: "1,6-anhydro-N-acetyl-beta-muramic acid catabolism" EXACT []
synonym: "1,6-anhydro-N-acetyl-beta-muramic acid degradation" EXACT []
synonym: "1,6-anhydro-N-acetylmuramate breakdown" EXACT []
synonym: "1,6-anhydro-N-acetylmuramate catabolic process" EXACT []
synonym: "1,6-anhydro-N-acetylmuramate catabolism" EXACT []
synonym: "1,6-anhydro-N-acetylmuramate degradation" EXACT []
synonym: "1,6-anhydro-N-acetylmuramic acid breakdown" EXACT []
synonym: "1,6-anhydro-N-acetylmuramic acid catabolic process" EXACT []
synonym: "1,6-anhydro-N-acetylmuramic acid catabolism" EXACT []
synonym: "1,6-anhydro-N-acetylmuramic acid degradation" EXACT []
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:0097174 ! 1,6-anhydro-N-acetyl-beta-muramic acid metabolic process
is_a: GO:1901136 ! carbohydrate derivative catabolic process
created_by: paola
creation_date: 2011-10-07T12:58:32Z

[Term]
id: GO:0097176
name: epoxide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving epoxides, compounds in which an oxygen atom is directly attached to two adjacent or non-adjacent carbon atoms of a carbon chain or ring system; thus cyclic ethers." [CHEBI:37407, GOC:rs, PMID:15822179]
synonym: "epoxide metabolism" EXACT []
is_a: GO:0018904 ! ether metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
created_by: paola
creation_date: 2011-10-10T11:29:49Z

[Term]
id: GO:0097177
name: mitochondrial ribosome binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any part of a mitochondrial ribosome, a ribosome found in the mitochondrion of a eukaryotic cell." [GOC:ans, PMID:20739282]
is_a: GO:0043022 ! ribosome binding
created_by: paola
creation_date: 2011-10-11T03:03:03Z

[Term]
id: GO:0097178
name: ruffle assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a ruffle, a projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. The formation of ruffles (also called membrane ruffling) is thought to be controlled by a group of enzymes known as Rho GTPases, specifically RhoA, Rac1 and cdc42." [GOC:yaf, http:en.wikipedia.org/wiki/Membrane_ruffling, PMID:12556481]
synonym: "membrane ruffle formation" EXACT []
synonym: "membrane ruffling" EXACT []
is_a: GO:0030031 ! cell projection assembly
is_a: GO:0031529 ! ruffle organization
created_by: paola
creation_date: 2011-10-16T01:46:09Z

[Term]
id: GO:0097179
name: protease inhibitor complex
namespace: cellular_component
def: "A heterodimeric protein complex that contains a protease inhibitor and a protease; formation of the complex inhibits protease activity." [GOC:ans, PMID:6323392]
synonym: "peptidase inhibitor complex" EXACT [GOC:bf, GOC:pr]
is_a: GO:0043234 ! protein complex
created_by: paola
creation_date: 2011-10-16T08:53:44Z

[Term]
id: GO:0097180
name: serine protease inhibitor complex
namespace: cellular_component
def: "A heterodimeric protein complex that contains a serine protease inhibitor and a protease; formation of the complex inhibits serine protease activity." [GOC:ans, PMID:6323392]
synonym: "serine-type endopeptidase inhibitor complex" EXACT [GOC:bf, GOC:pr]
synonym: "serpin complex" EXACT []
is_a: GO:0097179 ! protease inhibitor complex
created_by: paola
creation_date: 2011-10-16T08:55:17Z

[Term]
id: GO:0097181
name: protein C inhibitor-coagulation factor V complex
namespace: cellular_component
def: "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and coagulation factor V (F5); formation of the complex inhibits the serine protease activity of coagulation factor V." [GOC:ans, PMID:6323392]
synonym: "PCI-coagulation factor V complex" EXACT [PR:000014685]
synonym: "plasma serine protease inhibitor-coagulation factor V complex" EXACT [PR:000014685]
synonym: "protein C inhibitor-F5 complex" EXACT [PR:000007300]
synonym: "serpin A5-coagulation factor V complex" EXACT [PR:000014685]
synonym: "SERPINA5-coagulation factor V complex" EXACT [PR:000014685]
is_a: GO:0097180 ! serine protease inhibitor complex
created_by: paola
creation_date: 2011-10-16T08:57:03Z

[Term]
id: GO:0097182
name: protein C inhibitor-coagulation factor Xa complex
namespace: cellular_component
def: "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and coagulation factor Xa (F10); formation of the complex inhibits the serine protease activity of coagulation factor Xa." [GOC:ans, PMID:6323392]
synonym: "PCI-coagulation factor Xa complex" EXACT [PR:000014685]
synonym: "plasma serine protease inhibitor-coagulation factor Xa complex" EXACT [PR:000014685]
synonym: "serpin A5-coagulation factor Xa complex" EXACT [PR:000014685]
synonym: "SERPINA5-coagulation factor Xa complex" EXACT [PR:000014685]
is_a: GO:0097180 ! serine protease inhibitor complex
created_by: paola
creation_date: 2011-10-16T09:01:29Z

[Term]
id: GO:0097183
name: protein C inhibitor-coagulation factor XI complex
namespace: cellular_component
def: "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and coagulation factor XI (F11); formation of the complex inhibits the serine protease activity of coagulation factor XI." [GOC:ans, PMID:2844223]
synonym: "PCI-coagulation factor XI complex" EXACT [PR:000014685]
synonym: "plasma serine protease inhibitor-coagulation factor XI complex" EXACT [PR:000014685]
synonym: "protein C inhibitor-F11 complex" EXACT [PR:000007295]
synonym: "serpin A5-coagulation factor XI complex" EXACT [PR:000014685]
synonym: "SERPINA5-coagulation factor XI complex" EXACT [PR:000014685]
is_a: GO:0097180 ! serine protease inhibitor complex
created_by: paola
creation_date: 2011-10-16T09:03:22Z

[Term]
id: GO:0097184
name: response to azide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an azide stimulus." [CHEBI:40910, GOC:yaf, PMID:16846222]
is_a: GO:0010035 ! response to inorganic substance
is_a: GO:1901698 ! response to nitrogen compound
created_by: paola
creation_date: 2011-11-16T10:00:58Z

[Term]
id: GO:0097185
name: cellular response to azide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an azide stimulus." [CHEBI:40910, GOC:yaf, PMID:16846222]
is_a: GO:0071241 ! cellular response to inorganic substance
is_a: GO:0097184 ! response to azide
is_a: GO:1901699 ! cellular response to nitrogen compound
created_by: paola
creation_date: 2011-11-16T10:04:41Z

[Term]
id: GO:0097186
name: amelogenesis
namespace: biological_process
def: "The process whose specific outcome is the formation of tooth enamel, occurring in two stages: secretory stage and maturation stage." [GOC:cjm, GOC:sl, PMID:10206335, PMID:21196346]
synonym: "enamel development" EXACT []
is_a: GO:0042475 ! odontogenesis of dentin-containing tooth
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
created_by: paola
creation_date: 2011-11-21T09:01:24Z

[Term]
id: GO:0097187
name: dentinogenesis
namespace: biological_process
def: "The process whose specific outcome is the formation of dentin, the mineralized tissue that constitutes the major bulk of teeth. Dentin may be one of three types: primary dentin, secondary dentin, and tertiary dentin." [GOC:cjm, GOC:sl, PMID:10206335, PMID:21196346]
synonym: "dentin development" EXACT []
synonym: "dentine development" EXACT []
is_a: GO:0042475 ! odontogenesis of dentin-containing tooth
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
created_by: paola
creation_date: 2011-11-21T09:04:17Z

[Term]
id: GO:0097188
name: dentin mineralization
namespace: biological_process
def: "The process in which calcium salts are deposited into the calcareous tooth structure known as dentin." [GOC:sl, PMID:10206335, PMID:21196346]
synonym: "dentine mineralization" EXACT []
is_a: GO:0034505 ! tooth mineralization
relationship: part_of GO:0097187 ! dentinogenesis
created_by: paola
creation_date: 2011-11-21T09:05:43Z

[Term]
id: GO:0097189
name: apoptotic body
namespace: cellular_component
def: "A vesicle containing parts of a dying cell. Apoptotic bodies can be formed during the execution phase of the apoptotic process, when the cell's cytoskeleton breaks up and causes the membrane to bulge outward. These bulges may separate from the cell, taking a portion of cytoplasm with them, to become apoptotic bodies. These are then engulfed by phagocytic cells, and their components recycled. Apoptotic bodies may range in size from 0.8 to 5um." [GOC:mtg_apoptosis, GOC:vesicles, http://en.wikipedia.org/wiki/Apoptosis, http://en.wikipedia.org/wiki/Bleb_(cell_biology), PMID:15242875, PMID:24223256]
synonym: "apoptotic bleb" RELATED [GOC:vesicles]
synonym: "apoptotic vesicle" EXACT [GOC:vesicles]
is_a: GO:1903561 ! extracellular vesicle
created_by: paola
creation_date: 2011-11-22T08:05:20Z

[Term]
id: GO:0097190
name: apoptotic signaling pathway
namespace: biological_process
alt_id: GO:0008624
def: "A series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis]
comment: This term can be used to annotate gene products involved in apoptotic events happening downstream of the cross-talk point between the extrinsic and intrinsic apoptotic pathways. The cross-talk starts when caspase-8 cleaves Bid and truncated Bid interacts with mitochondria. From this point on it is not possible to distinguish between extrinsic and intrinsic pathways.
synonym: "apoptotic signalling pathway" EXACT [GOC:mah]
synonym: "induction of apoptosis by extracellular signals" EXACT []
xref: Reactome:REACT_101039 "Ceramide signalling, Canis familiaris"
xref: Reactome:REACT_101287 "Death Receptor Signalling, Xenopus tropicalis"
xref: Reactome:REACT_101722 "FasL/ CD95L signaling, Rattus norvegicus"
xref: Reactome:REACT_102105 "FASL binds FAS Receptor, Taeniopygia guttata"
xref: Reactome:REACT_102682 "Ceramide signalling, Bos taurus"
xref: Reactome:REACT_103565 "Death Receptor Signalling, Danio rerio"
xref: Reactome:REACT_104430 "Ceramide signalling, Gallus gallus"
xref: Reactome:REACT_104446 "Death Receptor Signalling, Bos taurus"
xref: Reactome:REACT_104880 "Cell death signalling via NRAGE, NRIF and NADE, Drosophila melanogaster"
xref: Reactome:REACT_105789 "Cell death signalling via NRAGE, NRIF and NADE, Canis familiaris"
xref: Reactome:REACT_1059 "Extrinsic Pathway for Apoptosis, Homo sapiens"
xref: Reactome:REACT_106019 "Ceramide signalling, Caenorhabditis elegans"
xref: Reactome:REACT_106417 "Cell death signalling via NRAGE, NRIF and NADE, Oryza sativa"
xref: Reactome:REACT_107145 "FASL binds FAS Receptor, Rattus norvegicus"
xref: Reactome:REACT_107277 "Cell death signalling via NRAGE, NRIF and NADE, Rattus norvegicus"
xref: Reactome:REACT_108226 "Ceramide signalling, Rattus norvegicus"
xref: Reactome:REACT_108738 "FASL binds FAS Receptor, Canis familiaris"
xref: Reactome:REACT_108954 "Cell death signalling via NRAGE, NRIF and NADE, Sus scrofa"
xref: Reactome:REACT_110327 "FASL binds FAS Receptor, Gallus gallus"
xref: Reactome:REACT_110777 "Extrinsic Pathway for Apoptosis, Canis familiaris"
xref: Reactome:REACT_113012 "Extrinsic Pathway for Apoptosis, Caenorhabditis elegans"
xref: Reactome:REACT_113720 "FasL/ CD95L signaling, Xenopus tropicalis"
xref: Reactome:REACT_114928 "Cell death signalling via NRAGE, NRIF and NADE, Dictyostelium discoideum"
xref: Reactome:REACT_115331 "FASL binds FAS Receptor, Xenopus tropicalis"
xref: Reactome:REACT_13720 "Cell death signalling via NRAGE, NRIF and NADE, Homo sapiens"
xref: Reactome:REACT_13806 "Ceramide signalling, Homo sapiens"
xref: Reactome:REACT_1426 "FASL binds FAS Receptor, Homo sapiens"
xref: Reactome:REACT_1619 "Death Receptor Signalling, Homo sapiens"
xref: Reactome:REACT_28136 "Death Receptor Signalling, Taeniopygia guttata"
xref: Reactome:REACT_30777 "Death Receptor Signalling, Sus scrofa"
xref: Reactome:REACT_32035 "FasL/ CD95L signaling, Danio rerio"
xref: Reactome:REACT_33023 "Ceramide signalling, Xenopus tropicalis"
xref: Reactome:REACT_33363 "Death Receptor Signalling, Gallus gallus"
xref: Reactome:REACT_47012 "Death Receptor Signalling, Mus musculus"
xref: Reactome:REACT_78512 "Ceramide signalling, Taeniopygia guttata"
xref: Reactome:REACT_78709 "Ceramide signalling, Drosophila melanogaster"
xref: Reactome:REACT_79738 "Extrinsic Pathway for Apoptosis, Xenopus tropicalis"
xref: Reactome:REACT_81353 "Ceramide signalling, Mus musculus"
xref: Reactome:REACT_81381 "FasL/ CD95L signaling, Gallus gallus"
xref: Reactome:REACT_82611 "Cell death signalling via NRAGE, NRIF and NADE, Taeniopygia guttata"
xref: Reactome:REACT_83750 "Extrinsic Pathway for Apoptosis, Gallus gallus"
xref: Reactome:REACT_84151 "Extrinsic Pathway for Apoptosis, Bos taurus"
xref: Reactome:REACT_85830 "Cell death signalling via NRAGE, NRIF and NADE, Danio rerio"
xref: Reactome:REACT_86320 "Cell death signalling via NRAGE, NRIF and NADE, Gallus gallus"
xref: Reactome:REACT_86807 "Death Receptor Signalling, Canis familiaris"
xref: Reactome:REACT_88410 "Cell death signalling via NRAGE, NRIF and NADE, Schizosaccharomyces pombe"
xref: Reactome:REACT_88562 "Ceramide signalling, Danio rerio"
xref: Reactome:REACT_89305 "FASL binds FAS Receptor, Bos taurus"
xref: Reactome:REACT_89421 "Cell death signalling via NRAGE, NRIF and NADE, Xenopus tropicalis"
xref: Reactome:REACT_900 "FasL/ CD95L signaling, Homo sapiens"
xref: Reactome:REACT_90409 "Ceramide signalling, Schizosaccharomyces pombe"
xref: Reactome:REACT_90414 "Cell death signalling via NRAGE, NRIF and NADE, Arabidopsis thaliana"
xref: Reactome:REACT_90980 "FasL/ CD95L signaling, Canis familiaris"
xref: Reactome:REACT_91488 "Cell death signalling via NRAGE, NRIF and NADE, Bos taurus"
xref: Reactome:REACT_92659 "Extrinsic Pathway for Apoptosis, Sus scrofa"
xref: Reactome:REACT_92947 "Extrinsic Pathway for Apoptosis, Danio rerio"
xref: Reactome:REACT_93354 "Ceramide signalling, Sus scrofa"
xref: Reactome:REACT_93927 "Cell death signalling via NRAGE, NRIF and NADE, Caenorhabditis elegans"
xref: Reactome:REACT_94832 "Ceramide signalling, Saccharomyces cerevisiae"
xref: Reactome:REACT_94837 "Extrinsic Pathway for Apoptosis, Taeniopygia guttata"
xref: Reactome:REACT_95750 "FASL binds FAS Receptor, Danio rerio"
xref: Reactome:REACT_95777 "FasL/ CD95L signaling, Taeniopygia guttata"
xref: Reactome:REACT_96066 "Death Receptor Signalling, Rattus norvegicus"
xref: Reactome:REACT_96229 "Extrinsic Pathway for Apoptosis, Rattus norvegicus"
xref: Reactome:REACT_96867 "Cell death signalling via NRAGE, NRIF and NADE, Saccharomyces cerevisiae"
xref: Reactome:REACT_97301 "Extrinsic Pathway for Apoptosis, Mus musculus"
xref: Reactome:REACT_98119 "Cell death signalling via NRAGE, NRIF and NADE, Mus musculus"
xref: Reactome:REACT_98804 "FasL/ CD95L signaling, Bos taurus"
xref: Reactome:REACT_99367 "FASL binds FAS Receptor, Mus musculus"
xref: Reactome:REACT_99865 "FasL/ CD95L signaling, Mus musculus"
is_a: GO:0007165 ! signal transduction
relationship: part_of GO:0006915 ! apoptotic process
created_by: paola
creation_date: 2011-11-23T09:30:23Z

[Term]
id: GO:0097191
name: extrinsic apoptotic signaling pathway
namespace: biological_process
def: "A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, GOC:yaf, PMID:17340152]
comment: Fas acts as a death receptor with a role in apoptosis, but can also act as a non-apoptotic signal transducer.
synonym: "death receptor-mediated apoptosis" NARROW []
synonym: "extrinsic apoptosis" NARROW []
synonym: "extrinsic apoptotic pathway" EXACT []
synonym: "extrinsic apoptotic signaling pathway in presence of ligand" NARROW []
synonym: "extrinsic apoptotic signalling pathway" EXACT [GOC:mah]
is_a: GO:0007166 ! cell surface receptor signaling pathway
is_a: GO:0097190 ! apoptotic signaling pathway
created_by: paola
creation_date: 2011-11-23T09:34:28Z

[Term]
id: GO:0097192
name: extrinsic apoptotic signaling pathway in absence of ligand
namespace: biological_process
def: "A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, PMID:15044679, PMID:20816705]
comment: For dependence receptors, absence of a ligand or withdrawal of a ligand from a receptor acts as a signal. An example of 'extrinsic apoptotic signaling pathway in absence of ligand' is withdrawal of a growth factor such as NGF, even if traditionally apoptosis induced via growth factor withdrawal has been classified as an instance of intrinsic apoptosis. See an example in PMID:19767770. Ligands whose withdrawal or absence induce apoptosis should be annotated to GO:2001239 'regulation of extrinsic apoptotic signaling pathway in absence of ligand', rather than to the pathway term itself. Examples of gene products that may be annotated to GO:0097192 'extrinsic apoptotic signaling pathway in absence of ligand' include dependence receptors such as DCC or UNC5B, which relay lethal signals in the absence of their ligand (netrin-1). In the case of DCC and UNC5B, the signaling proceeds through the assembly of a DRAL- and TUCAN- (or NLRP1-) containing caspase-9-activating complex or by the dephosphorylation-mediated activation of death-associated protein kinase 1 (DAPK1) by UNC5B-bound protein phosphatase 2A (PP2A), respectively. DAPK1 can mediate the direct activation of executioner caspases or favor MOMP (reviewed in PMID:21760595). Also see PMID:21172653 (annotations to UNC5B and PR65beta, UniProt symbols O08722, PPP2R1B and P30154).
synonym: "dependence receptor signaling pathway" RELATED []
synonym: "extrinsic apoptosis in absence of ligand" NARROW []
synonym: "extrinsic apoptotic signalling pathway in absence of ligand" EXACT [GOC:mah]
is_a: GO:0038034 ! signal transduction in absence of ligand
is_a: GO:0097191 ! extrinsic apoptotic signaling pathway
created_by: paola
creation_date: 2011-11-23T09:37:09Z

[Term]
id: GO:0097193
name: intrinsic apoptotic signaling pathway
namespace: biological_process
alt_id: GO:0008629
def: "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP)." [GOC:mtg_apoptosis, GOC:yaf, PMID:11919192, PMID:17340152, PMID:18852119]
comment: The signals that start intrinsic apoptosis may come from extracellular sources (e.g. oxidative stress, UV exposure), but the reception of the signal and thus the signaling pathway start inside the cell (as a result of DNA damage, redox imbalance, etc.). Examples are ZPR9 (ZNF622) and ASK1 (MAP3K5) (UniProt symbols Q969S3 and Q99683) in PMID:21771788. A diagram of the intrinsic apoptotic pathway including examples of molecular players can be found in Figure 2 in PMID:21760595.
synonym: "induction of apoptosis by intracellular signals" RELATED []
synonym: "intrinsic apoptosis" NARROW []
synonym: "intrinsic apoptotic pathway" EXACT []
synonym: "intrinsic apoptotic signalling pathway" EXACT [GOC:mah]
synonym: "mitochondrial-mediated apoptotic pathway" EXACT []
xref: Reactome:REACT_102619 "Intrinsic Pathway for Apoptosis, Mus musculus"
xref: Reactome:REACT_103356 "Intrinsic Pathway for Apoptosis, Sus scrofa"
xref: Reactome:REACT_113652 "Intrinsic Pathway for Apoptosis, Dictyostelium discoideum"
xref: Reactome:REACT_113707 "Intrinsic Pathway for Apoptosis, Drosophila melanogaster"
xref: Reactome:REACT_113789 "Intrinsic Pathway for Apoptosis, Oryza sativa"
xref: Reactome:REACT_114288 "Intrinsic Pathway for Apoptosis, Arabidopsis thaliana"
xref: Reactome:REACT_114326 "Intrinsic Pathway for Apoptosis, Schizosaccharomyces pombe"
xref: Reactome:REACT_114572 "Intrinsic Pathway for Apoptosis, Saccharomyces cerevisiae"
xref: Reactome:REACT_62033 "Intrinsic Pathway for Apoptosis, Canis familiaris"
xref: Reactome:REACT_78496 "Intrinsic Pathway for Apoptosis, Rattus norvegicus"
xref: Reactome:REACT_79211 "Intrinsic Pathway for Apoptosis, Plasmodium falciparum"
xref: Reactome:REACT_86317 "Intrinsic Pathway for Apoptosis, Danio rerio"
xref: Reactome:REACT_92763 "Intrinsic Pathway for Apoptosis, Gallus gallus"
xref: Reactome:REACT_94367 "Intrinsic Pathway for Apoptosis, Xenopus tropicalis"
xref: Reactome:REACT_96185 "Intrinsic Pathway for Apoptosis, Taeniopygia guttata"
xref: Reactome:REACT_964 "Intrinsic Pathway for Apoptosis, Homo sapiens"
xref: Reactome:REACT_96537 "Intrinsic Pathway for Apoptosis, Bos taurus"
is_a: GO:0035556 ! intracellular signal transduction
is_a: GO:0097190 ! apoptotic signaling pathway
created_by: paola
creation_date: 2011-11-23T09:40:50Z

[Term]
id: GO:0097194
name: execution phase of apoptosis
namespace: biological_process
def: "A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:mtg_apoptosis, PMID:21760595]
synonym: "apoptosis" NARROW []
synonym: "execution phase of apoptotic process" EXACT []
is_a: GO:0044763 ! single-organism cellular process
relationship: has_part GO:0032060 ! bleb assembly
relationship: part_of GO:0006915 ! apoptotic process
created_by: paola
creation_date: 2011-11-23T09:45:24Z

[Term]
id: GO:0097195
name: pilomotor reflex
namespace: biological_process
def: "The reflex process in which the arrectores pilorum (hair follicle) muscles contract and cause the hair to stand erect." [GOC:BHF, http://en.wikipedia.org/wiki/Pilomotor_reflex, PMID:21335239]
synonym: "goosebump reflex" EXACT []
synonym: "horripilation" EXACT []
synonym: "piloerection" EXACT []
is_a: GO:0060004 ! reflex
created_by: paola
creation_date: 2011-12-01T05:08:14Z

[Term]
id: GO:0097196
name: Shu complex
namespace: cellular_component
def: "A protein complex involved in error-free DNA post-replication repair (PRR). In Saccharomyces cerevisiae the complex contains Csm2p, Psy3p, Shu1p, and Shu2p." [GOC:jh, PMID:15654096, PMID:19496932]
is_a: GO:1990391 ! DNA repair complex
created_by: paola
creation_date: 2011-12-01T05:11:08Z

[Term]
id: GO:0097197
name: tetraspanin-enriched microdomain
namespace: cellular_component
def: "A pre-organized unit composed either of adhesion molecules (mainly integrins and members of the Ig superfamily), signaling receptors and/or enzyme-enriched plasma membrane domains that compartmentalizes cellular processes. Tetraspanin-enriched microdomains might be specially suited for the regulation of avidity of adhesion receptors and the compartmentalization of enzymatic activities." [GOC:ans, PMID:19709882, PMID:21930792]
synonym: "membrane tetraspanin-enriched microdomain" EXACT []
synonym: "TEM" EXACT []
is_a: GO:0044459 ! plasma membrane part
created_by: paola
creation_date: 2011-12-02T04:21:37Z

[Term]
id: GO:0097198
name: histone H3-K36 trimethylation
namespace: biological_process
def: "The modification of histone H3 by addition of three methyl groups to lysine at position 36 of the histone." [GOC:se, PMID:17948059]
is_a: GO:0010452 ! histone H3-K36 methylation
is_a: GO:0018023 ! peptidyl-lysine trimethylation
created_by: paola
creation_date: 2011-12-05T01:19:45Z

[Term]
id: GO:0097199
name: cysteine-type endopeptidase activity involved in apoptotic signaling pathway
namespace: molecular_function
def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic signaling pathway." [GOC:mtg_apoptosis, http://en.wikipedia.org/wiki/Caspase, PMID:11717445]
comment: Examples of gene products that may be annotated to this term include CASP2, CASP8, CASP9, and CASP10, also called initiator (or apical, or activator) caspases.
synonym: "activator caspase activity" NARROW []
synonym: "apical caspase activity" NARROW []
synonym: "cysteine-type endopeptidase activity involved in apoptotic signalling pathway" EXACT [GOC:mah]
synonym: "initiator caspase activity" NARROW []
is_a: GO:0004871 ! signal transducer activity
is_a: GO:0097153 ! cysteine-type endopeptidase activity involved in apoptotic process
intersection_of: GO:0004197 ! cysteine-type endopeptidase activity
intersection_of: part_of GO:0097190 ! apoptotic signaling pathway
relationship: part_of GO:0097190 ! apoptotic signaling pathway
created_by: paola
creation_date: 2011-12-12T01:43:00Z

[Term]
id: GO:0097200
name: cysteine-type endopeptidase activity involved in execution phase of apoptosis
namespace: molecular_function
def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the execution phase of apoptosis." [GOC:mtg_apoptosis, http://en.wikipedia.org/wiki/Caspase]
comment: Examples of gene products that may be annotated to this term include CASP3, CASP6 and CASP7, also called effector (or executioner) caspases.
synonym: "effector caspase activity" NARROW []
synonym: "executioner caspase activity" NARROW []
is_a: GO:0097153 ! cysteine-type endopeptidase activity involved in apoptotic process
intersection_of: GO:0004197 ! cysteine-type endopeptidase activity
intersection_of: part_of GO:0097194 ! execution phase of apoptosis
relationship: part_of GO:0097194 ! execution phase of apoptosis
created_by: paola
creation_date: 2011-12-12T01:46:06Z

[Term]
id: GO:0097201
name: negative regulation of transcription from RNA polymerase II promoter in response to stress
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:rn, PMID:11027285, PMID:15575969, PMID:16556235, PMID:18086556, PMID:18627600]
is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
is_a: GO:0043618 ! regulation of transcription from RNA polymerase II promoter in response to stress
created_by: paola
creation_date: 2011-12-14T09:16:22Z

[Term]
id: GO:0097202
name: activation of cysteine-type endopeptidase activity
namespace: biological_process
def: "Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase." [GOC:mtg_apoptosis, PMID:21726810]
comment: This term should be used to annotate gene products within the context of cellular processes other than apoptotic cell death (e.g., cell cycle arrest). To annotate gene products involved in activation of cysteine-type endopeptidases where the activation results in apoptotic process, please use the more granular term GO:0006919.
synonym: "activation of caspase activity" NARROW []
synonym: "activation of metacaspase activity" RELATED []
is_a: GO:0031638 ! zymogen activation
is_a: GO:2001056 ! positive regulation of cysteine-type endopeptidase activity
created_by: paola
creation_date: 2011-12-19T02:44:04Z

[Term]
id: GO:0097203
name: phagocytic cup lip
namespace: cellular_component
def: "The tip or margin of the progressing circular lamella that engulfs a particle during phagocytosis. When the two lips of the cup fuse it is converted into a phagosome." [GOC:pf, PMID:20200225]
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0001891 ! phagocytic cup
created_by: paola
creation_date: 2011-12-21T10:26:41Z

[Term]
id: GO:0097204
name: phagocytic cup base
namespace: cellular_component
def: "The older part of the phagocytic cup where the actin cytoskeleton disassembles, allowing early incoming and outgoing vesicular trafficking." [GOC:pf, PMID:20200225]
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0001891 ! phagocytic cup
created_by: paola
creation_date: 2011-12-21T10:29:07Z

[Term]
id: GO:0097205
name: renal filtration
namespace: biological_process
def: "A renal system process in which fluid circulating through the body is filtered through a barrier system." [GOC:pr, GOC:sart]
is_a: GO:0003014 ! renal system process
created_by: paola
creation_date: 2012-01-03T03:10:17Z

[Term]
id: GO:0097206
name: nephrocyte filtration
namespace: biological_process
def: "The process by which hemolymph is filtered based on size and charge through a nephrocyte filtration barrier formed by the basement membrane and nephrocyte diaphragm." [GOC:sart, PMID:18971929]
is_a: GO:0097205 ! renal filtration
created_by: paola
creation_date: 2012-01-03T03:13:31Z

[Term]
id: GO:0097207
name: bud dormancy process
namespace: biological_process
def: "A dormancy process in which dormancy (sometimes called a dormant state) is induced, maintained or broken in a bud. Bud dormancy is a suspension of most physiological activity and growth that can be reactivated. It may be a response to environmental conditions such as seasonality or extreme heat, drought, or cold. The exit from bud dormancy is marked by the resumed growth of the bud." [GOC:PO_curators, PO_REF:00009]
comment: Bud dormancy may precede dormancy of the whole plant.
synonym: "bud dormancy" RELATED []
is_a: GO:0022611 ! dormancy process
is_a: GO:0044707 ! single-multicellular organism process
is_a: GO:0044767 ! single-organism developmental process
created_by: paola
creation_date: 2012-01-04T01:18:24Z

[Term]
id: GO:0097208
name: alveolar lamellar body
namespace: cellular_component
def: "A specialized secretory organelle found in type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant." [GOC:cjm, http://en.wikipedia.org/wiki/Lamellar_granule]
is_a: GO:0042599 ! lamellar body
created_by: paola
creation_date: 2012-01-04T02:33:04Z

[Term]
id: GO:0097209
name: epidermal lamellar body
namespace: cellular_component
def: "A specialized secretory organelle found in keratinocytes and involved in the formation of an impermeable, lipid-containing membrane that serves as a water barrier and is required for correct skin barrier function." [GOC:cjm, http://en.wikipedia.org/wiki/Lamellar_granule]
is_a: GO:0042599 ! lamellar body
created_by: paola
creation_date: 2012-01-04T02:34:27Z

[Term]
id: GO:0097210
name: response to gonadotropin-releasing hormone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin-releasing hormone stimulus. Gonadotropin-releasing hormone (GnRH) is a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus." [GOC:yaf, PMID:15976007]
synonym: "response to GnRH" EXACT []
is_a: GO:0043434 ! response to peptide hormone
created_by: paola
creation_date: 2012-01-09T08:48:56Z

[Term]
id: GO:0097211
name: cellular response to gonadotropin-releasing hormone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin-releasing hormone stimulus. Gonadotropin-releasing hormone (GnRH) is a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus." [GOC:yaf, PMID:15976007]
synonym: "cellular response to GnRH" EXACT []
synonym: "cellular response to gonadotrophin-releasing hormone" EXACT [GOC:dph]
is_a: GO:0071375 ! cellular response to peptide hormone stimulus
is_a: GO:0097210 ! response to gonadotropin-releasing hormone
created_by: paola
creation_date: 2012-01-09T08:51:23Z

[Term]
id: GO:0097212
name: lysosomal membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosomal membrane. A lysosomal membrane is the lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:yaf, PMID:20544854]
synonym: "lysosomal membrane organisation" EXACT [GOC:mah]
synonym: "lysosome membrane organization" EXACT []
is_a: GO:0044802 ! single-organism membrane organization
relationship: part_of GO:0007040 ! lysosome organization
created_by: paola
creation_date: 2012-01-12T10:16:15Z

[Term]
id: GO:0097213
name: regulation of lysosomal membrane permeability
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by the lysosomal membrane." [GOC:yaf, PMID:20544854]
synonym: "regulation of lysosome membrane permeability" EXACT []
is_a: GO:0090559 ! regulation of membrane permeability
is_a: GO:0097212 ! lysosomal membrane organization
created_by: paola
creation_date: 2012-01-12T10:19:44Z

[Term]
id: GO:0097214
name: positive regulation of lysosomal membrane permeability
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the passage or uptake of molecules by the lysosomal membrane." [GOC:yaf, PMID:20544854]
synonym: "positive regulation of lysosome membrane permeability" EXACT []
is_a: GO:0097213 ! regulation of lysosomal membrane permeability
created_by: paola
creation_date: 2012-01-12T10:22:17Z

[Term]
id: GO:0097215
name: negative regulation of lysosomal membrane permeability
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the passage or uptake of molecules by the lysosomal membrane." [GOC:yaf, PMID:20544854]
synonym: "negative regulation of lysosome membrane permeability" EXACT []
is_a: GO:0097213 ! regulation of lysosomal membrane permeability
created_by: paola
creation_date: 2012-01-12T10:23:42Z

[Term]
id: GO:0097216
name: guanosine tetraphosphate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with guanosine tetraphosphate (5'-ppGpp-3'), a guanosine bisphosphate having diphosphate groups at both the 3' and 5'-positions." [CHEBI:17633, GOC:imk, PMID:15109491, PMID:16968770, PMID:18359660]
synonym: "5'-ppGpp-3' binding" EXACT []
is_a: GO:0032550 ! purine ribonucleoside binding
is_a: GO:0032561 ! guanyl ribonucleotide binding
is_a: GO:0043168 ! anion binding
created_by: paola
creation_date: 2012-01-13T08:35:50Z

[Term]
id: GO:0097217
name: sieve area
namespace: cellular_component
def: "A pit-like area in the cell wall of a sieve element; contains pores lined with callose and occupied by strands of protoplasmic material that interconnect the protoplasts of contiguous sieve elements." [ISBN:0471738433, POC:curators]
comment: Part of a sieve element (PO:0025406).
is_a: GO:0044426 ! cell wall part
relationship: part_of GO:0009505 ! plant-type cell wall
created_by: paola
creation_date: 2012-01-13T05:39:03Z

[Term]
id: GO:0097218
name: sieve plate
namespace: cellular_component
def: "A part of the cell wall of a sieve tube member that bears one or more highly specialized sieve areas." [ISBN:0471738433, POC:curators]
comment: Typical of angiosperms. Part of sieve tube member (PO:0000289).
is_a: GO:0044426 ! cell wall part
relationship: has_part GO:0097217 ! sieve area
relationship: part_of GO:0009505 ! plant-type cell wall
created_by: paola
creation_date: 2012-01-13T05:42:48Z

[Term]
id: GO:0097219
name: compound sieve plate
namespace: cellular_component
def: "A sieve plate that contains several specialized sieve areas in either a scalariform or reticulate arrangement." [ISBN:0471738433, POC:curators]
comment: Often located on an end wall of a sieve tube member. Unspecialized sieve areas may occur on other parts of the cell.
is_a: GO:0097218 ! sieve plate
created_by: paola
creation_date: 2012-01-13T05:45:23Z

[Term]
id: GO:0097220
name: simple sieve plate
namespace: cellular_component
def: "A sieve plate that contains a single specialized sieve area." [ISBN:0471738433, POC:curators]
comment: Often located on an end wall of a sieve tube member. Unspecialized sieve areas may occur on other parts of the cell.
is_a: GO:0097218 ! sieve plate
created_by: paola
creation_date: 2012-01-13T05:46:46Z

[Term]
id: GO:0097221
name: M/G1 phase-specific MADS box-forkhead transcription factor complex
namespace: cellular_component
def: "A protein complex that contains a MADS-box protein and two forkhead domain proteins, and binds to and regulates transcription from promoters of genes transcribed during the M/G1 transition of the cell cycle. In Schizosaccharomyces pombe, the complex contains the MADS-box protein Mbx1 and two forkhead proteins, Sep1 and Fkh2." [GOC:mah, PMID:18057023]
synonym: "PBF complex" NARROW []
synonym: "PBF transcription complex" NARROW [GOC:vw]
synonym: "PCB binding factor complex" NARROW []
synonym: "pombe cell cycle box binding factor complex" NARROW []
is_a: GO:0090575 ! RNA polymerase II transcription factor complex
created_by: paola
creation_date: 2012-01-18T08:18:27Z

[Term]
id: GO:0097222
name: mitochondrial mRNA polyadenylation
namespace: biological_process
def: "The enzymatic addition of a sequence of 40-60 adenylyl residues at the 3' end of a eukaryotic mitochondrial mRNA primary transcript. Mitochondria contain both stabilizing and destabilizing poly(A) tails." [GOC:ans, PMID:18083837]
is_a: GO:0006378 ! mRNA polyadenylation
is_a: GO:0090616 ! mitochondrial mRNA 3'-end processing
relationship: occurs_in GO:0005739 ! mitochondrion
created_by: paola
creation_date: 2012-01-24T02:47:19Z

[Term]
id: GO:0097223
name: sperm part
namespace: cellular_component
def: "Any constituent part of a sperm, a mature male germ cell that develops from a spermatid." [GOC:cjm]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: goantislim_grouping
subset: gocheck_do_not_annotate
is_a: GO:0044464 ! cell part
created_by: paola
creation_date: 2012-01-25T01:19:35Z

[Term]
id: GO:0097224
name: sperm connecting piece
namespace: cellular_component
def: "The segment of the sperm flagellum that attaches to the implantation fossa of the nucleus in the sperm head; from the remnant of the centriole at this point, the axoneme extends throughout the length of the flagellum." [GOC:cjm, MP:0009830]
is_a: GO:0044441 ! ciliary part
is_a: GO:0097223 ! sperm part
relationship: part_of GO:0036126 ! sperm flagellum
created_by: paola
creation_date: 2012-01-25T01:21:02Z

[Term]
id: GO:0097225
name: sperm midpiece
namespace: cellular_component
def: "The highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece." [GOC:cjm, MP:0009831]
is_a: GO:0044441 ! ciliary part
is_a: GO:0097223 ! sperm part
relationship: part_of GO:0036126 ! sperm flagellum
created_by: paola
creation_date: 2012-01-25T01:23:41Z

[Term]
id: GO:0097226
name: sperm mitochondrial sheath
namespace: cellular_component
def: "The tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum." [GOC:cjm, MP:0009832]
is_a: GO:0044441 ! ciliary part
is_a: GO:0097223 ! sperm part
relationship: part_of GO:0036126 ! sperm flagellum
created_by: paola
creation_date: 2012-01-25T01:25:08Z

[Term]
id: GO:0097227
name: sperm annulus
namespace: cellular_component
def: "The ring-like, filamentous structure located at the distal end of the midpiece of the sperm flagellum; the annulus is thought to form a diffusion barrier between the midpiece and the principal piece and serve as a stabilizing structure for tail rigidity." [GOC:cjm, MP:0009834]
is_a: GO:0044441 ! ciliary part
is_a: GO:0097223 ! sperm part
relationship: part_of GO:0036126 ! sperm flagellum
created_by: paola
creation_date: 2012-01-25T01:26:17Z

[Term]
id: GO:0097228
name: sperm principal piece
namespace: cellular_component
def: "The segment of the sperm flagellum where the mitochondrial sheath ends, and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs. The principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece." [GOC:cjm, MP:0009836]
is_a: GO:0044441 ! ciliary part
is_a: GO:0097223 ! sperm part
relationship: part_of GO:0036126 ! sperm flagellum
created_by: paola
creation_date: 2012-01-25T01:27:27Z

[Term]
id: GO:0097229
name: sperm end piece
namespace: cellular_component
def: "The short tip of the sperm flagellum, adjacent to the sperm principal piece and furthest from the sperm head, which contains only the axoneme surrounded by the plasma membrane." [GOC:cjm, GOC:sart, MP:0009837]
is_a: GO:0044441 ! ciliary part
is_a: GO:0097223 ! sperm part
relationship: part_of GO:0036126 ! sperm flagellum
created_by: paola
creation_date: 2012-01-25T01:29:04Z

[Term]
id: GO:0097230
name: cell motility in response to potassium ion
namespace: biological_process
def: "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another as a result of a potassium ion stimulus." [GOC:pf, PMID:19363786, PMID:21239624]
synonym: "K+ facilitation of cell motility" EXACT []
synonym: "potassium ion facilitation of cell motility" EXACT []
is_a: GO:0048870 ! cell motility
relationship: part_of GO:0035865 ! cellular response to potassium ion
created_by: paola
creation_date: 2012-01-25T04:39:45Z

[Term]
id: GO:0097231
name: cell motility in response to calcium ion
namespace: biological_process
def: "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another as a result of a calcium ion stimulus." [GOC:pf, PMID:19363786, PMID:21239624, PMID:8937985]
synonym: "Ca2+ facilitation of cell motility" EXACT []
synonym: "calcium ion facilitation of cell motility" EXACT []
is_a: GO:0048870 ! cell motility
relationship: part_of GO:0071277 ! cellular response to calcium ion
created_by: paola
creation_date: 2012-01-25T04:42:45Z

[Term]
id: GO:0097232
name: lamellar body membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a lamellar body. A lamellar body is a membrane-bounded organelle, specialized for the storage and secretion of various substances (surfactant phospholipids, glycoproteins and acid phosphates) which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae. Has some similar properties to, but is distinct from, a lysosome." [GOC:sl, PMID:11940594]
is_a: GO:0030667 ! secretory granule membrane
relationship: part_of GO:0042599 ! lamellar body
created_by: paola
creation_date: 2012-01-26T10:28:42Z

[Term]
id: GO:0097233
name: alveolar lamellar body membrane
namespace: cellular_component
def: "The lipid bilayer surrounding an alveolar lamellar body, a specialized secretory organelle found in type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant." [GOC:sl, PMID:11940594]
is_a: GO:0097232 ! lamellar body membrane
relationship: part_of GO:0097208 ! alveolar lamellar body
created_by: paola
creation_date: 2012-01-26T10:30:24Z

[Term]
id: GO:0097234
name: epidermal lamellar body membrane
namespace: cellular_component
def: "The lipid bilayer surrounding an epidermal lamellar body, a specialized secretory organelle found in keratinocytes and involved in the formation of an impermeable, lipid-containing membrane that serves as a water barrier and is required for correct skin barrier function." [GOC:sl, PMID:11940594]
is_a: GO:0097232 ! lamellar body membrane
relationship: part_of GO:0097209 ! epidermal lamellar body
created_by: paola
creation_date: 2012-01-26T10:32:13Z

[Term]
id: GO:0097235
name: positive regulation of fatty acid beta-oxidation by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of fatty acid beta-oxidation by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:1899286]
is_a: GO:0032000 ! positive regulation of fatty acid beta-oxidation
is_a: GO:0072366 ! regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
intersection_of: positively_regulates GO:0006635 ! fatty acid beta-oxidation
relationship: positively_regulates GO:0006635 ! fatty acid beta-oxidation
created_by: paola
creation_date: 2012-02-01T05:07:12Z

[Term]
id: GO:0097236
name: positive regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of zinc ions." [GOC:dgf, PMID:19702872]
is_a: GO:0034225 ! regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation
is_a: GO:0036003 ! positive regulation of transcription from RNA polymerase II promoter in response to stress
created_by: paola
creation_date: 2012-02-01T09:33:11Z

[Term]
id: GO:0097237
name: cellular response to toxic substance
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus." [GOC:pr]
is_a: GO:0009636 ! response to toxic substance
is_a: GO:0070887 ! cellular response to chemical stimulus
created_by: paola
creation_date: 2012-02-02T12:23:31Z

[Term]
id: GO:0097238
name: cellular response to methylglyoxal
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylglyoxal stimulus. Methylglyoxal is a 2-oxoaldehyde derived from propanal." [GOC:pr]
is_a: GO:0051595 ! response to methylglyoxal
is_a: GO:0071310 ! cellular response to organic substance
is_a: GO:1901655 ! cellular response to ketone
created_by: paola
creation_date: 2012-02-02T12:26:35Z

[Term]
id: GO:0097239
name: positive regulation of transcription from RNA polymerase II promoter in response to methylglyoxal
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to a methylglyoxal stimulus." [GOC:dgf, PMID:15773992]
is_a: GO:1901522 ! positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
relationship: part_of GO:0097238 ! cellular response to methylglyoxal
created_by: paola
creation_date: 2012-02-02T12:28:46Z

[Term]
id: GO:0097240
name: chromosome attachment to the nuclear envelope
namespace: biological_process
def: "The process in which chromatin is anchored to the nuclear envelope." [GOC:vw, PMID:22156749]
synonym: "attachment of chromatin to nuclear envelope" RELATED []
is_a: GO:0022402 ! cell cycle process
is_a: GO:0050000 ! chromosome localization
is_a: GO:1902580 ! single-organism cellular localization
created_by: paola
creation_date: 2012-02-07T01:11:37Z

[Term]
id: GO:0097241
name: hematopoietic stem cell migration to bone marrow
namespace: biological_process
def: "The orderly movement of a hematopoietic stem cell into the bone marrow, and its subsequent positioning within defined functional compartments in that microenvironment. A hematopoietic stem cell is a cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system." [CL:0000037, GOC:yaf, PMID:17368745]
synonym: "hematopoietic stem cell homing" BROAD []
synonym: "hemopoietic stem cell migration to bone marrow" EXACT []
synonym: "progenitor cell homing" BROAD []
is_a: GO:0035701 ! hematopoietic stem cell migration
created_by: paola
creation_date: 2012-02-09T01:08:32Z

[Term]
id: GO:0097242
name: beta-amyloid clearance
namespace: biological_process
def: "The process in which beta-amyloid is removed from the brain via receptors." [GOC:BHF, PMID:19098903]
is_a: GO:0044707 ! single-multicellular organism process
created_by: paola
creation_date: 2012-02-16T05:32:29Z

[Term]
id: GO:0097243
name: flavonoid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a flavonoid, a compound containing two or more aromatic rings, each bearing at least one aromatic hydroxyl and connected with a carbon bridge." [CHEBI:47916, GOC:sl, PMID:20599706]
is_a: GO:0005488 ! binding
created_by: paola
creation_date: 2012-02-17T03:49:16Z

[Term]
id: GO:0097244
name: flavonol binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a flavonol, a flavonoid that contains a 3-hydroxy-2-phenylchromen-4-one backbone." [CHEBI:5078, GOC:sl]
is_a: GO:0043168 ! anion binding
is_a: GO:0097243 ! flavonoid binding
created_by: paola
creation_date: 2012-02-17T03:50:45Z

[Term]
id: GO:0097245
name: flavanol binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a flavanol." [CHEBI:24036, GOC:sl]
synonym: "flavan-3-ol binding" NARROW []
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:0097243 ! flavonoid binding
is_a: GO:1901363 ! heterocyclic compound binding
created_by: paola
creation_date: 2012-02-17T03:52:10Z

[Term]
id: GO:0097246
name: catechin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a catechin, a polyphenolic antioxidant plant metabolite with a flavonoid or flavan-3-ol structure." [CHEBI:23053, GOC:sl]
is_a: GO:0097245 ! flavanol binding
created_by: paola
creation_date: 2012-02-17T03:53:54Z

[Term]
id: GO:0097247
name: epigallocatechin 3-gallate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with epigallocatechin 3-gallate, a compound that is a gallic acid ester of a catechin." [CHEBI:4806, GOC:sl, PMID:21307292]
synonym: "catechin gallate binding" BROAD []
synonym: "EGCG binding" EXACT []
is_a: GO:0097246 ! catechin binding
created_by: paola
creation_date: 2012-02-17T03:55:05Z

[Term]
id: GO:0097248
name: maintenance of protein location in cell cortex of cell tip
namespace: biological_process
def: "A process in which a protein or protein complex is maintained in a specific location in the cell cortex of a cell tip, and is prevented from moving elsewhere. The cell cortex of a cell tip is the region directly beneath the plasma membrane at either end of the longest axis of a cylindrical or elongated cell." [GOC:al, PMID:19646873]
is_a: GO:0032065 ! cortical protein anchoring
created_by: paola
creation_date: 2012-02-20T04:27:31Z

[Term]
id: GO:0097249
name: mitochondrial respiratory chain supercomplex
namespace: cellular_component
def: "A set of respiratory enzyme complexes of the mitochondrial inner membrane (including, for example, Complex II, Complex III, Complex IV, or F1-F0 ATPase) arranged to form a large supercomplex." [GOC:mcc, PMID:21909073, PMID:22342701]
synonym: "mitochondrial respirasome" EXACT []
synonym: "mitochondrial respiratory supercomplex" EXACT []
is_a: GO:0098800 ! inner mitochondrial membrane protein complex
relationship: part_of GO:0005743 ! mitochondrial inner membrane
created_by: paola
creation_date: 2012-02-23T05:13:54Z

[Term]
id: GO:0097250
name: mitochondrial respiratory chain supercomplex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of respiratory enzyme complexes of the mitochondrial inner membrane (including, for example, Complex II, Complex III, Complex IV, or F1-F0 ATPase) to form a large supercomplex." [GOC:mcc, PMID:21909073, PMID:22342701]
synonym: "mitochondrial respirasome assembly" EXACT []
synonym: "mitochondrial respiratory supercomplex assembly" EXACT []
is_a: GO:0007005 ! mitochondrion organization
is_a: GO:0043623 ! cellular protein complex assembly
created_by: paola
creation_date: 2012-02-23T05:18:41Z

[Term]
id: GO:0097251
name: leukotriene B4 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of leukotriene B4, a leukotriene composed of (6Z,8E,10E,14Z)-eicosatetraenoic acid having (5S)- and (12R)-hydroxy substituents." [CHEBI:15647, GOC:yaf, UniPathway:UPA00878]
synonym: "leukotriene B4 anabolism" EXACT []
synonym: "leukotriene B4 biosynthesis" EXACT []
synonym: "leukotriene B4 formation" EXACT []
synonym: "leukotriene B4 synthesis" EXACT []
synonym: "LTB4 anabolism" EXACT []
synonym: "LTB4 biosynthesis" EXACT []
synonym: "LTB4 formation" EXACT []
synonym: "LTB4 synthesis" EXACT []
is_a: GO:0019370 ! leukotriene biosynthetic process
is_a: GO:0036102 ! leukotriene B4 metabolic process
is_a: GO:0042759 ! long-chain fatty acid biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process
created_by: paola
creation_date: 2012-02-24T09:34:01Z

[Term]
id: GO:0097252
name: oligodendrocyte apoptotic process
namespace: biological_process
def: "Any apoptotic process in an oligodendrocyte. Oligodendrocytes belong to a class of large neuroglial (macroglial) cells in the central nervous system, where they form the insulating myelin sheath of axons." [CL:0000128, GOC:mtg_apoptosis, GOC:yaf, PMID:16723520]
synonym: "oligodendrocyte apoptosis" NARROW []
is_a: GO:0034349 ! glial cell apoptotic process
created_by: paola
creation_date: 2012-03-05T10:51:15Z

[Term]
id: GO:0097253
name: beta-hydroxybutyrate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of beta-hydroxybutyrate from one side of the membrane to the other. Beta-hydroxybutyrate is the conjugate base of (R)-3-hydroxybutyric acid." [CHEBI:10983, GOC:dsf, PMID:22302940]
synonym: "(R)-3-hydroxybutyrate transmembrane transporter activity" EXACT []
synonym: "3-hydroxybutanoic acid transmembrane transporter activity" EXACT []
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:0015245 ! fatty acid transporter activity
is_a: GO:0015665 ! alcohol transmembrane transporter activity
created_by: paola
creation_date: 2012-03-05T01:22:37Z

[Term]
id: GO:0097254
name: renal tubular secretion
namespace: biological_process
def: "Secretion of substances from peritubular capillaries into the renal tubules to be incorporated subsequently into the urine. Substances that are secreted include organic anions, ammonia, potassium and drugs." [GOC:rph, http://en.wikipedia.org/wiki/Renal_secretion#Secretion, http://fau.pearlashes.com/anatomy/Chapter%2041B/Chapter%2041B.htm, PMID:10049739]
is_a: GO:0003014 ! renal system process
is_a: GO:0044707 ! single-multicellular organism process
is_a: GO:0046903 ! secretion
created_by: paola
creation_date: 2012-03-05T02:03:58Z

[Term]
id: GO:0097255
name: R2TP complex
namespace: cellular_component
def: "A highly conserved protein complex comprised of two ATP-dependent DNA helicases (Rvb1p and Rvb2p in yeast, Pontin52 and Reptin52 in humans), Pih1p in yeast or PIH1D1 in humans, and Tah1 in yeast or RPAP3 in humans. The complex associates with Hsp90 and is thought to have a role in assembly of large protein or protein/nucleic acid complexes. In this role it is involved in multiple processes such as box C/D snoRNP biogenesis, phosphatidylinositol-3 kinase-related protein kinase (PIKK) signaling, RNA polymerase II assembly, and others." [GOC:mcc, PMID:15766533, PMID:21925213]
is_a: GO:0043234 ! protein complex
created_by: paola
creation_date: 2012-03-06T11:16:33Z

[Term]
id: GO:0097256
name: phenyllactate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the oxidation of phenyllactate to produce phenylpyruvate." [GOC:pde, PMID:15421980]
comment: This enzymatic activity is usually negligible, but may become prominent when phenylalanine levels are abnormally high as in the human disease phenylketonuria (PKU).
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors
created_by: paola
creation_date: 2012-03-07T11:39:39Z

[Term]
id: GO:0097257
name: leukotriene B4 12-hydroxy dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: leukotriene B4 + NADP(+) = 12-oxo-leukotriene B4 + NADPH + H(+)." [GOC:mw, KEGG:R03864, PMID:8394361, PMID:9461497]
synonym: "leukotriene B4 12-hydroxydehydrogenase activity" EXACT []
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors
created_by: paola
creation_date: 2012-03-07T02:07:41Z

[Term]
id: GO:0097258
name: 20-hydroxy-leukotriene B4 omega oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 20-hydroxy-leukotriene B4 + O2 + NADPH + H(+) = 20-aldehyde-leukotriene B4 + 2H2O + NADP(+)." [GOC:mw, PMID:2836406]
synonym: "20-hydroxy-leukotriene B4 omega-oxidase activity" EXACT []
synonym: "20-hydroxy-leukotriene B4 omega-oxidation" RELATED []
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors
created_by: paola
creation_date: 2012-03-07T03:37:53Z

[Term]
id: GO:0097259
name: 20-aldehyde-leukotriene B4 20-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 20-aldehyde-leukotriene B4 + O2 + NADPH + H(+) = 20-carboxy-leukotriene B4 + H2O + NADP(+)." [GOC:mw, PMID:2549038, PMID:2836406]
is_a: GO:0004497 ! monooxygenase activity
created_by: paola
creation_date: 2012-03-07T03:40:05Z

[Term]
id: GO:0097260
name: eoxin A4 synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: leukotriene A4 = eoxin A4." [GOC:mw, PMID:18184802, PMID:18647347]
is_a: GO:0016853 ! isomerase activity
created_by: paola
creation_date: 2012-03-08T02:57:23Z

[Term]
id: GO:0097261
name: eoxin C4 synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: eoxin A4 + glutathione = eoxin C4." [GOC:mw, PMID:18184802, PMID:18647347]
is_a: GO:0016846 ! carbon-sulfur lyase activity
created_by: paola
creation_date: 2012-03-08T02:59:00Z

[Term]
id: GO:0097262
name: eoxin D4 synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: eoxin C4 = eoxin D4 + 5-L-glutamyl amino acid." [GOC:mw, PMID:18184802, PMID:18647347]
is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups
created_by: paola
creation_date: 2012-03-08T03:01:00Z

[Term]
id: GO:0097263
name: eoxin E4 synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: eoxin D4 + H20 = eoxin E4 + glycine." [GOC:mw, PMID:18184802, PMID:18647347]
is_a: GO:0008238 ! exopeptidase activity
created_by: paola
creation_date: 2012-03-08T03:02:48Z

[Term]
id: GO:0097264
name: self proteolysis
namespace: biological_process
def: "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their own peptide bonds." [GOC:yaf, PMID:18676612, PMID:19144634]
synonym: "autolysis" BROAD []
synonym: "self-proteolysis" EXACT []
is_a: GO:0006508 ! proteolysis
created_by: paola
creation_date: 2012-03-09T12:43:24Z

[Term]
id: GO:0097265
name: 5(S)-hydroxyeicosatetraenoic acid dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-HETE + NADP(+) = 5-oxo-ETE + NADPH + H(+)." [GOC:mw, PMID:1326548]
synonym: "5(S)-HETE dehydrogenase activity" EXACT []
synonym: "5-HETE dehydrogenase activity" EXACT []
synonym: "5-hydroxy-eicosatetraenoic acid dehydrogenase activity" EXACT []
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
created_by: paola
creation_date: 2012-03-09T12:46:02Z

[Term]
id: GO:0097266
name: phenylacetyl-CoA 1,2-epoxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenylacetyl-CoA + H(+) + NADPH + O2 = 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP(+)." [EC:1.14.13.149, GOC:bf, GOC:gk, PMID:20660314, PMID:21247899]
synonym: "phenylacetyl-CoA epoxidase activity" EXACT [GOC:bf]
synonym: "phenylacetyl-CoA monooxygenase activity" EXACT [EC:1.14.13.149]
synonym: "ring 1,2-phenylacetyl-CoA epoxidase activity" EXACT [EC:1.14.13.149]
xref: EC:1.14.13.149
xref: KEGG:R09838
xref: RHEA:32174
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
created_by: paola
creation_date: 2012-03-13T09:22:47Z

[Term]
id: GO:0097267
name: omega-hydroxylase P450 pathway
namespace: biological_process
def: "The chemical reactions and pathways by which arachidonic acid is converted to other compounds initially by omega-hydroxylation." [GOC:mw, PMID:10681399]
synonym: "P450 omega-hydroxylase pathway" EXACT []
is_a: GO:0019369 ! arachidonic acid metabolic process
created_by: paola
creation_date: 2012-03-15T12:58:15Z

[Term]
id: GO:0097268
name: cytoophidium
namespace: cellular_component
def: "A subcellular filamentary structure where CTP synthase is compartmentalized in a range of organisms including bacteria, yeast, fruit fly, rat and human." [GOC:mag, http://en.wikipedia.org/wiki/CTP_synthase#Cytoophidium, PMID:20513629, PMID:21930098]
is_a: GO:0044464 ! cell part
created_by: paola
creation_date: 2012-03-15T01:00:20Z

[Term]
id: GO:0097269
name: all-trans-decaprenyl-diphosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all-trans-decaprenyl diphosphate." [EC:2.5.1.91, GOC:mw, PMID:16262699]
synonym: "(2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase activity" EXACT []
synonym: "2-trans,6-trans-farnesyl diphosphate activity" EXACT []
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups
created_by: paola
creation_date: 2012-03-20T01:00:23Z

[Term]
id: GO:0097270
name: dishabituation
namespace: biological_process
def: "The temporary recovery of response to a stimulus when a novel stimulus is added." [GOC:kmv, http://en.wikipedia.org/wiki/Habituation, PMID:11390637]
is_a: GO:0046958 ! nonassociative learning
created_by: paola
creation_date: 2012-03-20T01:39:25Z

[Term]
id: GO:0097271
name: protein localization to bud neck
namespace: biological_process
def: "A process in which a protein is transported to, or maintained at, a location within a cellular bud neck." [GOC:rb, PMID:22344253]
synonym: "protein localisation to bud neck" EXACT [GOC:mah]
synonym: "protein localization to cellular bud neck" EXACT []
is_a: GO:0034613 ! cellular protein localization
created_by: paola
creation_date: 2012-03-20T03:39:20Z

[Term]
id: GO:0097272
name: ammonia homeostasis
namespace: biological_process
def: "Any biological process involved in the maintenance of an internal steady state of ammonia." [GOC:yaf, PMID:12695560]
is_a: GO:0055067 ! monovalent inorganic cation homeostasis
is_a: GO:0055083 ! monovalent inorganic anion homeostasis
is_a: GO:0072505 ! divalent inorganic anion homeostasis
created_by: paola
creation_date: 2012-03-22T02:51:22Z

[Term]
id: GO:0097273
name: creatinine homeostasis
namespace: biological_process
def: "Any biological process involved in the maintenance of an internal steady state of creatinine." [GOC:yaf, PMID:12695560]
is_a: GO:0048878 ! chemical homeostasis
created_by: paola
creation_date: 2012-03-22T02:52:50Z

[Term]
id: GO:0097274
name: urea homeostasis
namespace: biological_process
def: "Any biological process involved in the maintenance of an internal steady state of urea." [GOC:yaf, PMID:12695560]
is_a: GO:0048878 ! chemical homeostasis
created_by: paola
creation_date: 2012-03-22T02:53:39Z

[Term]
id: GO:0097275
name: cellular ammonia homeostasis
namespace: biological_process
def: "Any biological process involved in the maintenance of an internal steady state of ammonia at the level of the cell." [GOC:yaf, PMID:12695560]
is_a: GO:0030004 ! cellular monovalent inorganic cation homeostasis
is_a: GO:0030320 ! cellular monovalent inorganic anion homeostasis
is_a: GO:0072501 ! cellular divalent inorganic anion homeostasis
is_a: GO:0097272 ! ammonia homeostasis
created_by: paola
creation_date: 2012-03-22T02:54:38Z

[Term]
id: GO:0097276
name: cellular creatinine homeostasis
namespace: biological_process
def: "Any biological process involved in the maintenance of an internal steady state of creatinine at the level of the cell." [GOC:yaf, PMID:12695560]
is_a: GO:0055082 ! cellular chemical homeostasis
is_a: GO:0097273 ! creatinine homeostasis
created_by: paola
creation_date: 2012-03-22T02:55:46Z

[Term]
id: GO:0097277
name: cellular urea homeostasis
namespace: biological_process
def: "Any biological process involved in the maintenance of an internal steady state of urea at the level of the cell." [GOC:yaf, PMID:12695560]
is_a: GO:0055082 ! cellular chemical homeostasis
is_a: GO:0097274 ! urea homeostasis
created_by: paola
creation_date: 2012-03-22T02:57:08Z

[Term]
id: GO:0097278
name: complement-dependent cytotoxicity
namespace: biological_process
def: "Lysis of a cell resulting from triggering of the complement cascade. An example can be seen with complement activation and subsequent lysis of a bacterial cell as a result of the binding of IgM to the cell surface followed by the binding of complement proteins to that antibody." [GOC:add, GOC:rv]
is_a: GO:0001906 ! cell killing
is_a: GO:0044699 ! single-organism process
relationship: has_part GO:0006956 ! complement activation
created_by: paola
creation_date: 2012-03-22T05:04:04Z

[Term]
id: GO:0097279
name: histamine secretion mediated by IgE immunoglobulin
namespace: biological_process
def: "Histamine release triggered by the binding of an antigen to an IgE immunoglobulin bound to the cell surface. An example is mast cell histamine degranulation as a result of exposure of mast cell-bound IgE to alder tree pollen." [GOC:add, GOC:rv]
synonym: "histamine secretion mediated by IgE antibody" EXACT []
synonym: "Ig-mediated histamine release" BROAD []
is_a: GO:0097280 ! histamine secretion mediated by immunoglobulin
created_by: paola
creation_date: 2012-03-22T06:42:13Z

[Term]
id: GO:0097280
name: histamine secretion mediated by immunoglobulin
namespace: biological_process
def: "Histamine release triggered by the binding of an antigen to an immunoglobulin bound to the cell surface." [GOC:add, GOC:rv, PMID:11490155, PMID:1719184]
is_a: GO:0002437 ! inflammatory response to antigenic stimulus
is_a: GO:0002441 ! histamine secretion involved in inflammatory response
relationship: has_part GO:0003823 ! antigen binding
created_by: paola
creation_date: 2012-03-26T01:30:25Z

[Term]
id: GO:0097281
name: immune complex formation
namespace: biological_process
def: "The process that gives rise to an immune complex. Immune complexes are clusters of antibodies bound to antigen, to which complement may also be fixed, and which may precipitate or remain in solution. Examples are the clumping of cells such as bacteria or red blood cells in the presence of an antibody, precipitation of a toxin after an antibody binds to it, and clumping of viral particles as a result of antibody binding to the virus." [GOC:add, GOC:rv]
synonym: "antibody-mediated agglutination" EXACT []
is_a: GO:0016064 ! immunoglobulin mediated immune response
relationship: has_part GO:0003823 ! antigen binding
created_by: paola
creation_date: 2012-03-26T01:35:21Z

[Term]
id: GO:0097282
name: immunoglobulin-mediated neutralization
namespace: biological_process
def: "The inhibition of an antigen's biological effects by antibody binding to it. An example is neutralization of diphtheria toxin by preventing its entry into human cells via the binding of antibody specific for diphtheria toxin." [GOC:add, GOC:rv]
synonym: "antibody-mediated neutralization" EXACT []
is_a: GO:0016064 ! immunoglobulin mediated immune response
relationship: has_part GO:0003823 ! antigen binding
created_by: paola
creation_date: 2012-03-26T01:55:24Z

[Term]
id: GO:0097283
name: keratinocyte apoptotic process
namespace: biological_process
def: "Any apoptotic process in a keratinocyte. A keratinocyte is an epidermal cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the basal layers of the epidermis to the cornified (horny) layer of the skin." [CL:0000312, GOC:jc, GOC:mtg_apoptosis, PMID:10201527]
synonym: "keratinocyte apoptosis" NARROW []
is_a: GO:1904019 ! epithelial cell apoptotic process
created_by: paola
creation_date: 2012-03-29T10:20:51Z

[Term]
id: GO:0097284
name: hepatocyte apoptotic process
namespace: biological_process
def: "Any apoptotic process in a hepatocyte, the main structural component of the liver." [CL:0000182, GOC:jc, GOC:mtg_apoptosis, PMID:15856020]
synonym: "hepatocyte apoptosis" NARROW []
is_a: GO:1904019 ! epithelial cell apoptotic process
created_by: paola
creation_date: 2012-03-29T10:23:21Z

[Term]
id: GO:0097285
name: obsolete cell-type specific apoptotic process
namespace: biological_process
def: "OBSOLETE. Any apoptotic process in a specific cell type." [GOC:mtg_apoptosis]
comment: This term was made obsolete because it was an unnecessary grouping term.
subset: gocheck_do_not_manually_annotate
synonym: "cell-type specific apoptosis" NARROW []
is_obsolete: true
consider: GO:0006915
created_by: paola
creation_date: 2012-03-29T04:00:25Z

[Term]
id: GO:0097286
name: iron ion import
namespace: biological_process
def: "The directed movement of iron ions into a cell or organelle." [GOC:mah, PMID:18622392]
is_a: GO:0006826 ! iron ion transport
created_by: paola
creation_date: 2012-04-18T03:33:45Z

[Term]
id: GO:0097287
name: 7-cyano-7-deazaguanine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the Q nucleoside precursor 7-cyano-7-deazaguanine, also known as 2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile or preQo." [CHEBI:45075, GOC:yaf, PMID:364423]
synonym: "7-cyano-7-deazaguanine metabolism" EXACT []
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:0050898 ! nitrile metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
created_by: paola
creation_date: 2012-04-25T10:50:50Z

[Term]
id: GO:0097288
name: 7-cyano-7-deazaguanine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the Q nucleoside precursor 7-cyano-7-deazaguanine, also known as 2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile or preQo." [CHEBI:45075, GOC:yaf, PMID:364423, UniPathway:UPA00391]
synonym: "7-cyano-7-deazaguanine anabolism" EXACT []
synonym: "7-cyano-7-deazaguanine biosynthesis" EXACT []
synonym: "7-cyano-7-deazaguanine formation" EXACT []
synonym: "7-cyano-7-deazaguanine synthesis" EXACT []
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0080028 ! nitrile biosynthetic process
is_a: GO:0097287 ! 7-cyano-7-deazaguanine metabolic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
created_by: paola
creation_date: 2012-04-25T10:53:47Z

[Term]
id: GO:0097289
name: alpha-ribazole metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving alpha-ribazole, the benzimidazole nucleoside in adenosyl cobalamin (vitamin B12)." [CHEBI:10329, GOC:yaf]
synonym: "alpha-ribazole metabolism" EXACT []
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process
is_a: GO:1901657 ! glycosyl compound metabolic process
created_by: paola
creation_date: 2012-04-25T11:49:24Z

[Term]
id: GO:0097290
name: alpha-ribazole biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of alpha-ribazole, the benzimidazole nucleoside in adenosyl cobalamin (vitamin B12)." [CHEBI:10329, GOC:yaf, MetaCyc:PWY-5508, MetaCyc:PWY-6269, UniPathway:UPA00061]
synonym: "alpha-ribazole anabolism" EXACT []
synonym: "alpha-ribazole biosynthesis" EXACT []
synonym: "alpha-ribazole formation" EXACT []
synonym: "alpha-ribazole synthesis" EXACT []
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0097289 ! alpha-ribazole metabolic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process
is_a: GO:1901659 ! glycosyl compound biosynthetic process
created_by: paola
creation_date: 2012-04-25T11:51:07Z

[Term]
id: GO:0097291
name: renal phosphate ion absorption
namespace: biological_process
def: "A renal system process in which phosphate ions are taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures." [GOC:lb, PMID:18784102, PMID:22506049]
synonym: "renal phosphate absorption" EXACT []
is_a: GO:0070293 ! renal absorption
created_by: paola
creation_date: 2012-04-25T03:34:48Z

[Term]
id: GO:0097292
name: XMP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving XMP, xanthosine monophosphate." [CHEBI:15652, GOC:yaf]
synonym: "XMP metabolism" EXACT []
is_a: GO:0009150 ! purine ribonucleotide metabolic process
is_a: GO:0009167 ! purine ribonucleoside monophosphate metabolic process
created_by: paola
creation_date: 2012-04-26T09:51:16Z

[Term]
id: GO:0097293
name: XMP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of XMP, xanthosine monophosphate." [CHEBI:15652, GOC:yaf]
synonym: "XMP anabolism" EXACT []
synonym: "XMP biosynthesis" EXACT []
synonym: "XMP formation" EXACT []
synonym: "XMP synthesis" EXACT []
is_a: GO:0009152 ! purine ribonucleotide biosynthetic process
is_a: GO:0009168 ! purine ribonucleoside monophosphate biosynthetic process
is_a: GO:0097292 ! XMP metabolic process
created_by: paola
creation_date: 2012-04-26T09:54:13Z

[Term]
id: GO:0097294
name: 'de novo' XMP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of XMP, xanthosine monophosphate, from simpler precursors." [CHEBI:15652, GOC:yaf, MetaCyc:IMP-DEHYDROG-RXN, UniPathway:UPA00601]
synonym: "'de novo' XMP anabolism" EXACT []
synonym: "'de novo' XMP biosynthesis" EXACT []
synonym: "'de novo' XMP formation" EXACT []
synonym: "'de novo' XMP synthesis" EXACT []
is_a: GO:0097293 ! XMP biosynthetic process
created_by: paola
creation_date: 2012-04-26T09:57:49Z

[Term]
id: GO:0097295
name: morphine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of morphine, 17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol. Morphine is a highly potent opiate analgesic psychoactive drug obtained form the opium poppy, Papaver somniferum." [CHEBI:17303, GOC:yaf, UniPathway:UPA00852]
synonym: "morphine anabolism" EXACT []
synonym: "morphine biosynthesis" EXACT []
synonym: "morphine formation" EXACT []
synonym: "morphine synthesis" EXACT []
is_a: GO:0033075 ! isoquinoline alkaloid biosynthetic process
is_a: GO:0071272 ! morphine metabolic process
is_a: GO:1901378 ! organic heteropentacyclic compound biosynthetic process
created_by: paola
creation_date: 2012-05-02T09:51:19Z

[Term]
id: GO:0097296
name: activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
namespace: biological_process
def: "Any process that initiates the activity of an inactive cysteine-type endopeptidase involved in the apoptotic signaling pathway." [GOC:mtg_apoptosis]
comment: Components of the DISC (death-inducing signaling complex) may be annotated to this term. These include ligand-bound receptors such as FAS/CD95 (though care should be taken because FAS can also act as a non-apoptotic signal transducer), and signaling molecules such as FADD (FAS-associated protein with a death domain), cIAPs (cellular inhibitor of apoptosis proteins), c-FLIPs and caspases 8 and 10. Note that GO:0097296 should only be used to annotate gene products directly involved in the initiation or start up of an inactive cysteine-type endopeptidase activity involved in the apoptotic signaling pathway (also known as an initiator caspase). If the evidence provided is not sufficient to account for direct activation of this enzymatic activity, consider using the more generic terms GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway or GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process.
synonym: "activation of cysteine-type endopeptidase activity involved in apoptotic signalling pathway" EXACT []
synonym: "activation of initiator caspase activity" NARROW []
is_a: GO:0006919 ! activation of cysteine-type endopeptidase activity involved in apoptotic process
is_a: GO:2001269 ! positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
intersection_of: GO:0097202 ! activation of cysteine-type endopeptidase activity
intersection_of: part_of GO:0097190 ! apoptotic signaling pathway
relationship: part_of GO:0097190 ! apoptotic signaling pathway
created_by: paola
creation_date: 2012-05-02T03:19:35Z

[Term]
id: GO:0097297
name: activation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
namespace: biological_process
def: "Any process that initiates the activity of an inactive cysteine-type endopeptidase involved in the execution phase of apoptosis." [GOC:mtg_apoptosis]
comment: Note that this term should only be used to annotate gene products directly involved in the initiation or start up of an inactive cysteine-type endopeptidase activity involved in the execution phase of apoptosis (also known as an effector caspase). If the evidence provided is not sufficient to account for direct activation of this enzymatic activity, consider using the more generic terms GO:2001272 positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis or GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process.
synonym: "activation of effector caspase activity" NARROW []
is_a: GO:0006919 ! activation of cysteine-type endopeptidase activity involved in apoptotic process
is_a: GO:2001272 ! positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
intersection_of: GO:0097202 ! activation of cysteine-type endopeptidase activity
intersection_of: part_of GO:0097194 ! execution phase of apoptosis
relationship: part_of GO:0097194 ! execution phase of apoptosis
created_by: paola
creation_date: 2012-05-02T03:23:01Z

[Term]
id: GO:0097298
name: regulation of nucleus size
namespace: biological_process
def: "Any process that modulates the size of the nucleus." [GOC:al, GOC:mah, PMID:19366728]
synonym: "regulation of nuclear size" EXACT []
synonym: "regulation of nuclear volume" EXACT []
is_a: GO:0032535 ! regulation of cellular component size
created_by: paola
creation_date: 2012-05-03T06:21:43Z

[Term]
id: GO:0097299
name: cysteine-type endopeptidase activity involved in plant-type hypersensitive response
namespace: molecular_function
def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to plant-type hypersensitive response, the rapid, localized death of plant cells in response to invasion by a pathogen." [GOC:mtg_apoptosis]
synonym: "metacaspase activity involved in plant-type hypersensitive response" NARROW []
is_a: GO:0004197 ! cysteine-type endopeptidase activity
intersection_of: GO:0004197 ! cysteine-type endopeptidase activity
intersection_of: part_of GO:0009626 ! plant-type hypersensitive response
relationship: part_of GO:0009626 ! plant-type hypersensitive response
created_by: paola
creation_date: 2012-05-04T02:09:55Z

[Term]
id: GO:0097300
name: programmed necrotic cell death
namespace: biological_process
def: "A necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors." [GOC:mtg_apoptosis, PMID:21760595]
comment: This term may be used when annotating instances of programmed cell death characterized by necrotic morphology where the involvement of RIPK1 and/or RIPK3 is not shown. See PMID:23818611 for some examples.
synonym: "programmed cell death by necrosis" EXACT []
synonym: "regulated necrosis" BROAD []
is_a: GO:0012501 ! programmed cell death
is_a: GO:0070265 ! necrotic cell death
created_by: paola
creation_date: 2012-05-04T03:03:39Z

[Term]
id: GO:0097301
name: regulation of potassium ion concentration by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that regulates the internal concentration of potassium ions at the level of a cell by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:20412803]
synonym: "cellular potassium ion homeostasis by positive regulation of transcription from RNA polymerase II promoter" EXACT []
synonym: "potassium ion homeostasis by positive regulation of transcription from RNA polymerase II promoter" BROAD []
is_a: GO:0030007 ! cellular potassium ion homeostasis
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
created_by: paola
creation_date: 2012-05-09T09:03:02Z

[Term]
id: GO:0097302
name: lipoprotein biosynthetic process via diacylglyceryl transfer
namespace: biological_process
def: "The chemical reactions and pathways by which diacylglyceryl transfer leads to formation of a water-soluble protein-lipid complex." [GOC:pde, GOC:yaf, UniPathway:UPA00664]
synonym: "lipoprotein biosynthesis (diacylglyceryl transfer)" EXACT []
is_a: GO:0042158 ! lipoprotein biosynthetic process
created_by: paola
creation_date: 2012-05-15T01:02:02Z

[Term]
id: GO:0097303
name: lipoprotein biosynthetic process via N-acyl transfer
namespace: biological_process
def: "The chemical reactions and pathways by which N-acyl transfer leads to formation of a water-soluble protein-lipid complex." [GOC:pde, GOC:yaf, UniPathway:UPA00666]
synonym: "lipoprotein biosynthesis (N-acyl transfer)" EXACT []
is_a: GO:0042158 ! lipoprotein biosynthetic process
created_by: paola
creation_date: 2012-05-15T01:03:59Z

[Term]
id: GO:0097304
name: lipoprotein biosynthetic process via signal peptide cleavage
namespace: biological_process
def: "The chemical reactions and pathways by which signal peptide cleavage leads to formation of a water-soluble protein-lipid complex." [GOC:pde, GOC:yaf, UniPathway:UPA00665]
synonym: "lipoprotein biosynthesis (signal peptide cleavage)" EXACT []
is_a: GO:0042158 ! lipoprotein biosynthetic process
created_by: paola
creation_date: 2012-05-15T01:05:17Z

[Term]
id: GO:0097305
name: response to alcohol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alcohol stimulus." [CHEBI:30879, GOC:pr]
is_a: GO:0010033 ! response to organic substance
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: paola
creation_date: 2012-05-15T03:48:45Z

[Term]
id: GO:0097306
name: cellular response to alcohol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alcohol stimulus." [CHEBI:30879, GOC:pr]
is_a: GO:0071310 ! cellular response to organic substance
is_a: GO:0097305 ! response to alcohol
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: paola
creation_date: 2012-05-15T03:49:51Z

[Term]
id: GO:0097307
name: response to farnesol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a farnesol stimulus." [CHEBI:28600, GOC:pr]
is_a: GO:0033993 ! response to lipid
is_a: GO:0097305 ! response to alcohol
created_by: paola
creation_date: 2012-05-15T03:51:31Z

[Term]
id: GO:0097308
name: cellular response to farnesol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a farnesol stimulus." [CHEBI:28600, GOC:di, PMID:11425711]
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:0097306 ! cellular response to alcohol
is_a: GO:0097307 ! response to farnesol
created_by: paola
creation_date: 2012-05-15T03:54:01Z

[Term]
id: GO:0097309
name: cap1 mRNA methylation
namespace: biological_process
def: "Methylation of the ribose of the first nucleotide of a 5'-capped mRNA." [GOC:sp, PMID:20713356]
synonym: "cap1 mRNA capping" BROAD []
is_a: GO:0036451 ! cap mRNA methylation
created_by: paola
creation_date: 2012-05-23T04:03:13Z

[Term]
id: GO:0097310
name: cap2 mRNA methylation
namespace: biological_process
def: "Methylation of the ribose of the first and second nucleotides of a 5'-capped mRNA." [GOC:sp, PMID:20713356]
synonym: "cap2 mRNA capping" BROAD []
is_a: GO:0036451 ! cap mRNA methylation
created_by: paola
creation_date: 2012-05-23T04:05:07Z

[Term]
id: GO:0097311
name: biofilm matrix
namespace: cellular_component
def: "A structure lying external to bacterial cells. A biofilm is an aggregate of surface-associated bacteria, and the biofilm matrix is the envelope of polymeric substances that surrounds the bacteria." [GOC:imk, http://en.wikipedia.org/wiki/Biofilm, PMID:22571672]
is_a: GO:0031012 ! extracellular matrix
created_by: paola
creation_date: 2012-05-24T11:20:50Z

[Term]
id: GO:0097312
name: biofilm matrix component
namespace: cellular_component
def: "Any constituent part of the biofilm matrix, a structure lying external to bacterial cells. A biofilm is an aggregate of surface-associated bacteria, and the biofilm matrix is the envelope of polymeric substances that surrounds the bacteria." [GOC:imk, http://en.wikipedia.org/wiki/Biofilm, PMID:22571672]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "biofilm matrix part" EXACT []
is_a: GO:0044420 ! extracellular matrix component
intersection_of: GO:0005575 ! cellular_component
intersection_of: part_of GO:0097311 ! biofilm matrix
relationship: part_of GO:0097311 ! biofilm matrix
created_by: paola
creation_date: 2012-05-24T11:22:56Z

[Term]
id: GO:0097313
name: biofilm matrix surface
namespace: cellular_component
def: "The external part of the biofilm matrix, a structure lying external to bacterial cells. A biofilm is an aggregate of surface-associated bacteria, and the biofilm matrix is the envelope of polymeric substances that surrounds the bacteria." [GOC:imk, http://en.wikipedia.org/wiki/Biofilm, PMID:22571672]
is_a: GO:0097312 ! biofilm matrix component
relationship: part_of GO:0097311 ! biofilm matrix
created_by: paola
creation_date: 2012-05-24T11:25:47Z

[Term]
id: GO:0097314
name: apoptosome assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of the apoptosome, a multisubunit protein complex involved in the signaling phase of the apoptotic process." [GOC:mtg_apoptosis]
synonym: "apoptosome formation" EXACT []
is_a: GO:0006461 ! protein complex assembly
relationship: part_of GO:0097190 ! apoptotic signaling pathway
created_by: paola
creation_date: 2012-05-28T03:39:49Z

[Term]
id: GO:0097315
name: response to N-acetyl-D-glucosamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an N-acetyl-D-glucosamine stimulus." [CHEBI:506227, GOC:di, PMID:21700702]
is_a: GO:0010033 ! response to organic substance
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: paola
creation_date: 2012-05-30T03:58:54Z

[Term]
id: GO:0097316
name: cellular response to N-acetyl-D-glucosamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an N-acetyl-D-glucosamine stimulus." [CHEBI:506227, GOC:di, PMID:21700702]
is_a: GO:0071310 ! cellular response to organic substance
is_a: GO:0097315 ! response to N-acetyl-D-glucosamine
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: paola
creation_date: 2012-05-30T04:01:02Z

[Term]
id: GO:0097317
name: invasive growth in response to biotic stimulus
namespace: biological_process
def: "The growth of colonies in filamentous chains of cells as a result of a biotic stimulus. An example of this is Candida albicans forming invasive filaments in agar medium in response to a serum stimulus." [GOC:di, PMID:18679170]
is_a: GO:0036180 ! filamentous growth of a population of unicellular organisms in response to biotic stimulus
is_a: GO:0036267 ! invasive filamentous growth
created_by: paola
creation_date: 2012-05-31T10:38:16Z

[Term]
id: GO:0097318
name: invasive growth in response to abiotic stimulus
namespace: biological_process
def: "The growth of colonies in filamentous chains of cells as a result of a abiotic stimulus. An example of this process is found in Candida albicans." [GOC:di, PMID:18679170]
is_a: GO:0009628 ! response to abiotic stimulus
is_a: GO:0036267 ! invasive filamentous growth
created_by: paola
creation_date: 2012-05-31T10:39:31Z

[Term]
id: GO:0097319
name: carbohydrate import into cell
namespace: biological_process
def: "The directed movement of carbohydrate from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [GOC:al]
is_a: GO:0008643 ! carbohydrate transport
is_a: GO:0098657 ! import into cell
created_by: paola
creation_date: 2012-05-31T02:45:02Z

[Term]
id: GO:0097320
name: membrane tubulation
namespace: biological_process
def: "A modification in a plasma membrane resulting in formation of a tubular invagination." [GOC:BHF, PMID:15252009, PMID:20730103]
synonym: "plasma membrane tubulation" EXACT []
synonym: "vesicle scission" RELATED []
is_a: GO:0007009 ! plasma membrane organization
created_by: paola
creation_date: 2012-05-31T10:01:22Z

[Term]
id: GO:0097321
name: cell growth mode switching, filamentous to budding
namespace: biological_process
def: "The process in which a cell switches from growing as a filament (elongated cells attached end-to-end) to growing as a round budding cell. An example of this is observed in Candida albicans." [GOC:di, PMID:14617167]
is_a: GO:0070784 ! regulation of growth of unicellular organism as a thread of attached cells
created_by: paola
creation_date: 2012-06-05T11:28:06Z

[Term]
id: GO:0097322
name: 7SK snRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a 7SK small nuclear RNA (7SK snRNA)." [GOC:nhn, PMID:21853533]
synonym: "7SK small nuclear RNA binding" EXACT []
is_a: GO:0017069 ! snRNA binding
created_by: paola
creation_date: 2012-06-05T11:42:23Z

[Term]
id: GO:0097323
name: B cell adhesion
namespace: biological_process
def: "The attachment of a B cell to another cell via adhesion molecules." [GOC:jc]
is_a: GO:0007159 ! leukocyte cell-cell adhesion
created_by: paola
creation_date: 2012-06-06T01:59:19Z

[Term]
id: GO:0097324
name: melanocyte migration
namespace: biological_process
def: "The orderly movement of melanocytes from one site to another, often during the development of a multicellular organism. A melanocyte is a pigment cell derived from the neural crest. It contains melanin-filled pigment granules, which give a brown to black appearance." [CL:0000148, GOC:uh, PMID:22637532]
is_a: GO:0010631 ! epithelial cell migration
created_by: paola
creation_date: 2012-06-08T10:08:18Z

[Term]
id: GO:0097325
name: melanocyte proliferation
namespace: biological_process
def: "The multiplication or reproduction of melanocytes, resulting in the expansion of a cell population. A melanocyte is a pigment cell derived from the neural crest. It contains melanin-filled pigment granules, which give a brown to black appearance." [CL:0000148, GOC:uh, PMID:22637532]
is_a: GO:0050673 ! epithelial cell proliferation
created_by: paola
creation_date: 2012-06-08T10:10:12Z

[Term]
id: GO:0097326
name: melanocyte adhesion
namespace: biological_process
def: "The attachment of a melanocyte to another cell via adhesion molecules." [CL:0000148, GOC:uh, PMID:22637532]
is_a: GO:0090136 ! epithelial cell-cell adhesion
created_by: paola
creation_date: 2012-06-08T10:12:03Z

[Term]
id: GO:0097327
name: response to antineoplastic agent
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antineoplastic agent stimulus. An antineoplastic agent is a substance that inhibits or prevents the proliferation of neoplasms." [CHEBI:35610, GOC:pr]
is_a: GO:0042493 ! response to drug
created_by: paola
creation_date: 2012-06-12T10:48:28Z

[Term]
id: GO:0097328
name: response to carboplatin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carboplatin stimulus." [CHEBI:31355, GOC:pr]
is_a: GO:1990267 ! response to transition metal nanoparticle
created_by: paola
creation_date: 2012-06-12T10:50:34Z

[Term]
id: GO:0097329
name: response to antimetabolite
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antimetabolite stimulus. An antimetabolite is a substance which is structurally similar to a metabolite but which competes with it or replaces it, and so prevents or reduces its normal utilization." [CHEBI:35221, GOC:pr]
is_a: GO:0042221 ! response to chemical
created_by: paola
creation_date: 2012-06-12T10:52:01Z

[Term]
id: GO:0097330
name: response to 5-fluoro-2'-deoxyuridine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 5-fluoro-2'-deoxyuridine stimulus. 5-fluoro-2'-deoxyuridine is a pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; it is used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract." [CHEBI:60761, GOC:pr]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: paola
creation_date: 2012-06-12T10:53:35Z

[Term]
id: GO:0097331
name: response to cytarabine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytarabine stimulus." [CHEBI:28680, GOC:pr]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1903416 ! response to glycoside
created_by: paola
creation_date: 2012-06-12T10:55:29Z

[Term]
id: GO:0097332
name: response to antipsychotic drug
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antipsychotic drug stimulus. Antipsychotic drugs are agents that control agitated psychotic behaviour, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect." [CHEBI:35476, GOC:pr]
is_a: GO:0042493 ! response to drug
created_by: paola
creation_date: 2012-06-12T10:58:13Z

[Term]
id: GO:0097333
name: response to olanzapine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an olanzapine stimulus." [CHEBI:7735, GOC:pr]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
created_by: paola
creation_date: 2012-06-12T11:00:04Z

[Term]
id: GO:0097334
name: response to perphenazine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a perphenazine stimulus. Perphenazine is a phenothiazine derivative having a chloro substituent at the 2-position and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at the N-10 position." [CHEBI:8028, GOC:pr]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0097305 ! response to alcohol
created_by: paola
creation_date: 2012-06-12T11:01:14Z

[Term]
id: GO:0097335
name: response to quetiapine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a quetiapine stimulus." [CHEBI:8707, GOC:pr]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
created_by: paola
creation_date: 2012-06-12T11:03:22Z

[Term]
id: GO:0097336
name: response to risperidone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a risperidone stimulus." [CHEBI:8871, GOC:pr]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: paola
creation_date: 2012-06-12T11:04:31Z

[Term]
id: GO:0097337
name: response to ziprasidone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ziprasidone stimulus. Ziprasidone is a piperazine compound having 1,2-benzothiazol-3-yl- and 2-(6-chloro-1,3-dihydro-2-oxindol-5-yl)ethyl substituents attached to the nitrogen atoms." [CHEBI:10119, GOC:pr]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
created_by: paola
creation_date: 2012-06-12T11:05:31Z

[Term]
id: GO:0097338
name: response to clozapine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a clozapine stimulus." [CHEBI:3766, GOC:pr]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
created_by: paola
creation_date: 2012-06-12T11:07:01Z

[Term]
id: GO:0097339
name: glycolate transmembrane transport
namespace: biological_process
def: "A process in which glycolate is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. Glycolate is the anion of hydroxyethanoic acid (glycolic acid)." [CHEBI:29805, GOC:am, PMID:11283302, PMID:11785976]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "glycolate membrane transport" EXACT []
is_a: GO:1900866 ! glycolate transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport
created_by: paola
creation_date: 2012-06-12T05:12:35Z

[Term]
id: GO:0097340
name: inhibition of cysteine-type endopeptidase activity
namespace: biological_process
def: "Any process that prevents the activation of an inactive cysteine-type endopeptidase." [GOC:mtg_apoptosis, PMID:20383739]
synonym: "inhibition of caspase activity" NARROW []
synonym: "prevention of caspase activity" NARROW []
synonym: "prevention of cysteine-type endopeptidase activity" EXACT []
is_a: GO:0097341 ! zymogen inhibition
is_a: GO:2000117 ! negative regulation of cysteine-type endopeptidase activity
created_by: paola
creation_date: 2012-06-18T11:23:05Z

[Term]
id: GO:0097341
name: zymogen inhibition
namespace: biological_process
def: "Any process that prevents the proteolytic processing of an inactive enzyme to an active form." [GOC:mtg_apoptosis, PMID:20383739]
synonym: "prevention of zymogen activation" EXACT []
is_a: GO:0010955 ! negative regulation of protein processing
created_by: paola
creation_date: 2012-06-18T11:25:45Z

[Term]
id: GO:0097342
name: ripoptosome
namespace: cellular_component
def: "A protein complex whose core components are the receptor-interacting serine/threonine-protein kinases RIPK1 and RIPK3 (also called RIP1 and RIP3). Formation of the ripoptosome can induce an extrinsic apoptotic signaling pathway or a necroptotic signaling pathway. The composition of this protein complex may depend on several factors including nature of the signal, cell type and more." [GOC:bhm, GOC:mtg_apoptosis, PMID:22265414, PMID:22274400]
comment: It has been shown that receptor-mediated necroptotic signaling pathway requires assembly of a ripoptosome protein complex consisting of caspase-8, caspase-10, Fas-associated death domain protein (FADD), casp8 and FADD-like apoptosis regulator (CFLAR) as well as the two receptor-interacting serine/threonine-protein kinases RIPK1 and RIPK3 (PMID:21737330). Optionally, depending on the receptor activated, this complex may contain TLR3 adaptor protein TRIF (PMID:21737330).
synonym: "necrosome" RELATED []
synonym: "TNFR1 complex II" NARROW [PMID:22089168]
synonym: "Tnfr1-CII" NARROW [PMID:22089168]
is_a: GO:0044445 ! cytosolic part
is_a: GO:1902494 ! catalytic complex
relationship: part_of GO:0005829 ! cytosol
created_by: paola
creation_date: 2012-06-18T12:55:34Z

[Term]
id: GO:0097343
name: ripoptosome assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a ripoptosome, a protein complex whose formation can induce an extrinsic apoptotic signaling pathway or a necroptotic signaling pathway. The composition of this protein complex may depend on several factors including nature of the signal, cell type and more." [GOC:mtg_apoptosis, PMID:22274400]
is_a: GO:0006461 ! protein complex assembly
created_by: paola
creation_date: 2012-06-18T12:57:20Z

[Term]
id: GO:0097344
name: Rix1 complex
namespace: cellular_component
def: "A protein complex that comprises Rix1p, Ipi1p and Ipi3p, and is required for processing of ITS2 sequences from 35S pre-rRNA. The Rix1 complex has been identified in budding yeast and fission yeast, and members of this complex are conserved in higher eukaryotes." [GOC:vw, PMID:14759368, PMID:15260980, PMID:21385875]
synonym: "IPI complex" EXACT []
is_a: GO:0043234 ! protein complex
created_by: paola
creation_date: 2012-06-18T01:38:49Z

[Term]
id: GO:0097345
name: mitochondrial outer membrane permeabilization
namespace: biological_process
def: "The process by which the mitochondrial outer membrane becomes permeable to the passing of proteins and other molecules from the intermembrane space to the cytosol as part of the apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:pg, PMID:21041309]
comment: BAX and BAK are involved in this process, as reviewed in PMID:21760595 (the human proteins have UniProt symbols Q07812 and Q16611 respectively).
synonym: "mitochondrial outer membrane permeabilization" BROAD []
synonym: "mitochondrial outer membrane permeabilization during apoptotic cell death" BROAD []
synonym: "MOMP" EXACT []
is_a: GO:1902110 ! positive regulation of mitochondrial membrane permeability involved in apoptotic process
relationship: part_of GO:0097190 ! apoptotic signaling pathway
created_by: paola
creation_date: 2012-06-19T04:06:54Z

[Term]
id: GO:0097346
name: INO80-type complex
namespace: cellular_component
def: "A chromatin remodeling protein complex initially purified from S. cerevisiae and containing more than 10 subunits, including the SWR1-related complexes. INO80 (inositol requiring 80)-type complexes have diverse functions, including promoting transcriptional activation and DNA repair." [GOC:rb, PMID:19355820]
is_a: GO:0070603 ! SWI/SNF superfamily-type complex
created_by: paola
creation_date: 2012-06-20T11:26:55Z

[Term]
id: GO:0097347
name: TAM protein secretion complex
namespace: cellular_component
def: "A heterooligomeric protein complex that spans the bacterial periplasm and enables the secretion of adhesin proteins in Gram-negative bacteria. In Citrobacter rodentium, Salmonella enterica and Escherichia coli, the TAM complex consists of an Omp85-family protein, TamA, in the outer membrane and TamB in the inner membrane." [GOC:am, PMID:22466966]
synonym: "translocation and assembly module protein complex" EXACT []
is_a: GO:0043234 ! protein complex
created_by: paola
creation_date: 2012-06-21T10:44:15Z

[Term]
id: GO:0097348
name: host cell endocytic vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a host cell endocytic vesicle." [GOC:ecd]
is_a: GO:0044162 ! host cell cytoplasmic vesicle membrane
created_by: paola
creation_date: 2012-06-25T10:31:34Z

[Term]
id: GO:0097350
name: neutrophil clearance
namespace: biological_process
def: "The selective elimination of senescent neutrophils from the body by autoregulatory mechanisms." [GOC:BHF, PMID:21957127]
is_a: GO:0048771 ! tissue remodeling
relationship: has_part GO:0006909 ! phagocytosis
relationship: part_of GO:0001780 ! neutrophil homeostasis
created_by: paola
creation_date: 2012-06-27T03:53:38Z

[Term]
id: GO:0097351
name: toxin-antitoxin pair type II binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a toxic protein, disabling its function. There may be more than one antitoxin to a toxic protein. Instances of this activity are known only in prokaryotes, where the toxic protein may be a ribonuclease, a DNA gyrase, or other." [GOC:rs, http://en.wikipedia.org/wiki/Toxin-antitoxin_system#Type_II, PMID:19143615, PMID:19325885, PMID:21819231, PMID:22545240]
is_a: GO:0005515 ! protein binding
created_by: paola
creation_date: 2012-06-28T11:41:38Z

[Term]
id: GO:0097352
name: autophagosome maturation
namespace: biological_process
alt_id: GO:0000046
def: "The process in which autophagosomes, double-membraned vacuoles containing cytoplasmic material fuse with a vacuole (yeast) or lysosome (e.g. mammals and insects). In the case of yeast, inner membrane-bounded structures (autophagic bodies) appear in the vacuole. Fusion provides an acidic environment and digestive function to the interior of the autophagosome." [GOC:autophagy, GOC:lf, PMID:11099404, PMID:16874026, PMID:17534139]
synonym: "amphisome-lysosome fusion" NARROW []
synonym: "autolysosome formation" NARROW []
synonym: "autophagic vacuole fusion" EXACT [GOC:autophagy]
synonym: "autophagic vacuole maturation" EXACT [GOC:autophagy]
synonym: "autophagosome fusion" EXACT []
synonym: "fusion of autophagosome with lysosome" NARROW []
is_a: GO:0097576 ! vacuole fusion
is_a: GO:1902589 ! single-organism organelle organization
relationship: has_part GO:0016240 ! autophagosome docking
relationship: part_of GO:0016236 ! macroautophagy
created_by: paola
creation_date: 2012-06-28T03:12:18Z

[Term]
id: GO:0097353
name: centrolateral pattern formation
namespace: biological_process
def: "The regionalization process in which the areas along the centrolateral axis are established that will lead to differences in cell differentiation, or in which cells interpret a specific environment." [GOC:dsz]
synonym: "mediolateral pattern formation" EXACT []
is_a: GO:0003002 ! regionalization
created_by: paola
creation_date: 2012-07-02T11:34:08Z

[Term]
id: GO:0097354
name: prenylation
namespace: biological_process
def: "The covalent attachment of a prenyl group to a molecule; geranyl, farnesyl, or geranylgeranyl groups may be added." [GOC:di, PMID:18029206, PMID:21351751, PMID:22123822, PMID:22642693, PMID:22660767]
is_a: GO:0044237 ! cellular metabolic process
created_by: paola
creation_date: 2012-07-03T01:12:19Z

[Term]
id: GO:0097355
name: protein localization to heterochromatin
namespace: biological_process
def: "Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into heterochromatin." [GOC:mah]
synonym: "protein localisation to heterochromatin" EXACT [GOC:mah]
is_a: GO:0071168 ! protein localization to chromatin
created_by: paola
creation_date: 2012-07-03T03:19:07Z

[Term]
id: GO:0097356
name: perinucleolar compartment
namespace: cellular_component
def: "The perinucleolar compartment (PNC) is a subnuclear structure associated with, but structurally distinct from, the nucleolus. The PNC contains large amounts of the heterogeneous nuclear ribonucleoprotein complex (hnRNP) called hnRNP 1 (PTB). Many RNA binding proteins as well as RNA polymerase III transcripts are highly enriched in this compartment. PTB and pol III transcripts are required for the integrity of the PNC." [GOC:vw, http://en.wikipedia.org/wiki/Perinucleolar_compartment, PMID:21385875]
synonym: "perinucleolar region" EXACT []
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0031981 ! nuclear lumen
created_by: paola
creation_date: 2012-07-03T05:11:01Z

[Term]
id: GO:0097357
name: myo-inositol import into cell
namespace: biological_process
def: "The directed movement of myo-inositol from outside of a cell into the intracellular region of a cell." [GOC:mah]
is_a: GO:0015798 ! myo-inositol transport
created_by: paola
creation_date: 2012-07-03T06:22:05Z

[Term]
id: GO:0097358
name: D-leucyl-tRNA(Leu) deacylase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-leucyl-tRNA(Leu) = D-leucine + tRNA(Leu). Hydrolysis of the removal of D-leucine from residues in charged tRNA(Leu)." [GOC:se, PMID:10918062]
is_a: GO:0051499 ! D-aminoacyl-tRNA deacylase activity
created_by: paola
creation_date: 2012-07-04T09:18:12Z

[Term]
id: GO:0097359
name: UDP-glucosylation
namespace: biological_process
def: "The covalent attachment of a UDP-glucose residue to a substrate molecule." [GOC:al]
is_a: GO:0006011 ! UDP-glucose metabolic process
created_by: paola
creation_date: 2012-07-06T02:26:35Z

[Term]
id: GO:0097360
name: chorionic trophoblast cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of chorionic trophoblast cells, resulting in the expansion of their population." [CL:0011101, GOC:BHF, PMID:15150278]
is_a: GO:0008283 ! cell proliferation
created_by: paola
creation_date: 2012-07-19T10:17:37Z

[Term]
id: GO:0097361
name: CIA complex
namespace: cellular_component
def: "The cytosolic iron-sulfur protein assembly (CIA) complex mediates the incorporation of iron-sulfur clusters into apoproteins involved in DNA metabolism and genomic integrity." [GOC:sp, PMID:22678362]
synonym: "cytosolic iron-sulfur protein assembly complex" RELATED []
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part
created_by: paola
creation_date: 2012-07-20T02:07:22Z

[Term]
id: GO:0097362
name: MCM8-MCM9 complex
namespace: cellular_component
def: "A hexameric protein complex composed of MCM8 and MCM9 and involved in homologous recombination repair following DNA interstrand cross-links." [GOC:sp, PMID:22771115, PMID:22771120]
is_a: GO:0042555 ! MCM complex
created_by: paola
creation_date: 2012-07-20T02:10:12Z

[Term]
id: GO:0097363
name: protein O-GlcNAc transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + [protein]-L-serine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine, or UDP-N-acetyl-D-glucosamine + [protein]-L-threonine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine." [EC:2.4.1.255, GOC:jsg, GOC:sart, PMID:22158438]
synonym: "O-GlcNAc transferase" EXACT []
synonym: "O-linked N-acetylglucosaminyltransferase" EXACT []
synonym: "OGTase" EXACT []
synonym: "UDP-N-acetyl-D-glucosamine:protein-O-beta-N-acetyl-D-glucosaminyl transferase" EXACT []
is_a: GO:0008194 ! UDP-glycosyltransferase activity
created_by: paola
creation_date: 2012-07-24T01:46:51Z

[Term]
id: GO:0097364
name: stretch-activated, cation-selective, calcium channel activity involved in regulation of action potential
namespace: molecular_function
def: "Enables the transmembrane transfer of a calcium ion by a channel that opens in response to a mechanical stress in the form of stretching, and contributing to the regulation of action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:21290758]
is_a: GO:0015275 ! stretch-activated, cation-selective, calcium channel activity
intersection_of: GO:0015275 ! stretch-activated, cation-selective, calcium channel activity
intersection_of: regulates GO:0001508 ! action potential
relationship: regulates GO:0001508 ! action potential
created_by: paola
creation_date: 2012-07-25T04:08:33Z

[Term]
id: GO:0097365
name: stretch-activated, cation-selective, calcium channel activity involved in regulation of cardiac muscle cell action potential
namespace: molecular_function
def: "Enables the transmembrane transfer of a calcium ion by a channel that opens in response to a mechanical stress in the form of stretching, and contributing to the regulation of action potential in a cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:21290758]
is_a: GO:0097364 ! stretch-activated, cation-selective, calcium channel activity involved in regulation of action potential
intersection_of: GO:0015275 ! stretch-activated, cation-selective, calcium channel activity
intersection_of: regulates GO:0086001 ! cardiac muscle cell action potential
relationship: regulates GO:0086001 ! cardiac muscle cell action potential
created_by: paola
creation_date: 2012-07-26T02:39:10Z

[Term]
id: GO:0097366
name: response to bronchodilator
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bronchodilator stimulus. A bronchodilator is a chemical that causes an increase in the expansion of a bronchus or bronchial tubes." [CHEBI:35523, GOC:hp]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
synonym: "response to bronchodilator agent" EXACT []
synonym: "response to broncholytic agent" RELATED []
is_a: GO:0042493 ! response to drug
created_by: paola
creation_date: 2012-08-01T16:13:31Z

[Term]
id: GO:0097367
name: carbohydrate derivative binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a carbohydrate derivative." [GOC:pr]
is_a: GO:0005488 ! binding
created_by: paola
creation_date: 2012-08-02T13:03:39Z

[Term]
id: GO:0097368
name: establishment of Sertoli cell barrier
namespace: biological_process
def: "Establishment of a structure near the basement membrane in adjacent Sertoli cells of the seminiferous epithelium for maintaining spermatogenesis. The structure consists of tight junctions, basal ectoplasmic specializations, and desmosome-like junctions." [GOC:sl, http://en.wikipedia.org/wiki/Blood-testis_barrier, PMID:19509333]
synonym: "establishment of blood-testis barrier" EXACT []
synonym: "establishment of BTB" EXACT []
synonym: "establishment of SCB" EXACT []
is_a: GO:0060009 ! Sertoli cell development
created_by: paola
creation_date: 2012-08-02T17:05:55Z

[Term]
id: GO:0097369
name: sodium ion import
namespace: biological_process
def: "The directed movement of sodium ions into a cell or organelle." [GOC:BHF]
synonym: "sodium import" EXACT []
is_a: GO:0035725 ! sodium ion transmembrane transport
created_by: paola
creation_date: 2012-08-03T16:55:52Z

[Term]
id: GO:0097370
name: protein O-GlcNAcylation via threonine
namespace: biological_process
def: "The glycosylation of a protein by addition of N-acetylglucosamine via the O3 atom of peptidyl-threonine, forming O3-N-acetylglucosamine-L-threonine." [GOC:pr, GOC:sart, PMID:22158438]
is_a: GO:0018243 ! protein O-linked glycosylation via threonine
is_a: GO:1901135 ! carbohydrate derivative metabolic process
created_by: paola
creation_date: 2012-08-06T16:57:37Z

[Term]
id: GO:0097371
name: MDM2/MDM4 family protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any isoform of the MDM2/MDM4 protein family, comprising negative regulators of p53." [InterPro:IPR016495]
is_a: GO:0005515 ! protein binding
created_by: paola
creation_date: 2012-08-08T16:20:59Z

[Term]
id: GO:0097372
name: NAD-dependent histone deacetylase activity (H3-K18 specific)
namespace: molecular_function
def: "Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 18) + H2O = histone H3 L-lysine (position 18) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 18 of the histone H3 protein." [EC:3.5.1.17, GOC:sp, PMID:22722849, RHEA:24551]
is_a: GO:0017136 ! NAD-dependent histone deacetylase activity
is_a: GO:0034739 ! histone deacetylase activity (H4-K16 specific)
created_by: paola
creation_date: 2012-09-05T13:16:39Z

[Term]
id: GO:0097373
name: MCM core complex
namespace: cellular_component
def: "A protein complex that contains Mcm4, Mcm6, and Mcm7 proteins, and possesses DNA helicase activity. In the heterohexameric MCM complex, the Mcm4/6/7 proteins form a stable core, and Mcm2, Mcm3, and Mcm5 are more peripherally associated." [GOC:mah, PMID:10770926, PMID:15007098, PMID:9305914]
synonym: "MCM4/6/7 complex" EXACT []
is_a: GO:0043234 ! protein complex
created_by: paola
creation_date: 2012-09-12T10:41:42Z

[Term]
id: GO:0097374
name: sensory neuron axon guidance
namespace: biological_process
def: "The process in which the migration of an axon growth cone of a sensory neuron is directed to a specific target site in response to a combination of attractive and repulsive cues. A sensory neuron is an afferent neuron conveying sensory impulses." [CL:0000101, GOC:pr]
is_a: GO:0007411 ! axon guidance
created_by: paola
creation_date: 2012-10-01T10:16:22Z

[Term]
id: GO:0097375
name: spinal sensory neuron axon guidance
namespace: biological_process
def: "The process in which the migration of an axon growth cone of a spinal sensory neuron is directed to a specific target site in response to a combination of attractive and repulsive cues. A spinal sensory neuron is a sensory neuron that project to the spinal cord." [CL:0009000, GOC:pr, GOC:yaf]
is_a: GO:0097374 ! sensory neuron axon guidance
created_by: paola
creation_date: 2012-10-01T10:17:20Z

[Term]
id: GO:0097376
name: interneuron axon guidance
namespace: biological_process
def: "The process in which the migration of an axon growth cone of an interneuron is directed to a specific target site in response to a combination of attractive and repulsive cues. An interneuron is any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region, as contrasted with projection neurons which have axons projecting to other brain regions." [CL:0000099, GOC:pr]
is_a: GO:0007411 ! axon guidance
created_by: paola
creation_date: 2012-10-01T10:18:35Z

[Term]
id: GO:0097377
name: spinal cord interneuron axon guidance
namespace: biological_process
def: "The process in which the migration of an axon growth cone of a spinal cord interneuron is directed to a specific target site in response to a combination of attractive and repulsive cues. A spinal cord interneuron is a CNS interneuron located in the spinal cord." [CL:0005000, GOC:pr]
is_a: GO:0097376 ! interneuron axon guidance
created_by: paola
creation_date: 2012-10-01T10:19:42Z

[Term]
id: GO:0097378
name: dorsal spinal cord interneuron axon guidance
namespace: biological_process
def: "The process in which the migration of an axon growth cone of a dorsal spinal cord interneuron is directed to a specific target site in response to a combination of attractive and repulsive cues. A dorsal spinal cord interneuron is an interneuron located in the dorsal part of the spinal cord." [GOC:yaf]
synonym: "dorsal interneuron axon guidance" EXACT []
is_a: GO:0097377 ! spinal cord interneuron axon guidance
created_by: paola
creation_date: 2012-10-01T10:20:48Z

[Term]
id: GO:0097379
name: dorsal spinal cord interneuron posterior axon guidance
namespace: biological_process
def: "The process in which the migration of an axon growth cone of a dorsal spinal cord interneuron is directed to a specific target site in the posterior direction along the anterior-posterior body axis in response to a combination of attractive and repulsive cues. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:yaf, PMID:19545367]
synonym: "dorsal interneuron caudal axon projection" RELATED []
is_a: GO:0033564 ! anterior/posterior axon guidance
is_a: GO:0097378 ! dorsal spinal cord interneuron axon guidance
created_by: paola
creation_date: 2012-10-01T10:22:38Z

[Term]
id: GO:0097380
name: dorsal spinal cord interneuron anterior axon guidance
namespace: biological_process
def: "The process in which the migration of an axon growth cone of a dorsal spinal cord interneuron is directed to a specific target site in the anterior direction along the anterior-posterior body axis in response to a combination of attractive and repulsive cues. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:yaf, PMID:19545367]
synonym: "dorsal interneuron rostral axon projection" RELATED []
is_a: GO:0033564 ! anterior/posterior axon guidance
is_a: GO:0097378 ! dorsal spinal cord interneuron axon guidance
created_by: paola
creation_date: 2012-10-01T10:24:41Z

[Term]
id: GO:0097381
name: photoreceptor disc membrane
namespace: cellular_component
def: "Ovally-shaped membranous stack located inside the photoreceptor outer segment, and containing densely packed molecules of the photoreceptor protein rhodopsin that traverse the lipid bilayer. Disc membranes are apparently derived from the plasma membrane in the region of the cilium that connects the photoreceptor outer segment to the inner segment." [GOC:bj, PMID:11826267, PMID:2537204, PMID:7507907]
is_a: GO:0060170 ! ciliary membrane
is_a: GO:0097458 ! neuron part
relationship: part_of GO:0001750 ! photoreceptor outer segment
created_by: paola
creation_date: 2012-10-05T11:01:22Z

[Term]
id: GO:0097382
name: deoxynucleoside-diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: a deoxynucleoside diphosphate + H2O = a deoxynucleotide + phosphate." [GOC:pde]
is_a: GO:0016462 ! pyrophosphatase activity
created_by: paola
creation_date: 2012-10-11T16:03:22Z

[Term]
id: GO:0097383
name: dIDP diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: dIDP + H2O = dIMP + phosphate." [GOC:pde, PMID:20385596]
synonym: "deoxyinosine-diphosphatase activity" EXACT []
is_a: GO:0097382 ! deoxynucleoside-diphosphatase activity
created_by: paola
creation_date: 2012-10-11T16:04:40Z

[Term]
id: GO:0097384
name: cellular lipid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lipids, as carried out by individual cells." [GOC:pr]
synonym: "cellular lipid anabolism" EXACT []
synonym: "cellular lipid biosynthesis" EXACT []
synonym: "cellular lipid formation" EXACT []
synonym: "cellular lipid synthesis" EXACT []
is_a: GO:0008610 ! lipid biosynthetic process
is_a: GO:0044255 ! cellular lipid metabolic process
created_by: paola
creation_date: 2012-10-16T16:47:09Z

[Term]
id: GO:0097385
name: programmed necrotic cell death in response to starvation
namespace: biological_process
def: "A programmed necrotic cell death occurring as a result of a starvation stimulus (deprivation of nourishment)." [GOC:mtg_apoptosis, GOC:pg, PMID:13679856]
synonym: "necrotic cell death in response to starvation" BROAD []
is_a: GO:0042594 ! response to starvation
is_a: GO:0097300 ! programmed necrotic cell death
created_by: paola
creation_date: 2012-10-22T09:02:18Z

[Term]
id: GO:0097386
name: glial cell projection
namespace: cellular_component
def: "A prolongation or process extending from a glial cell." [GOC:mc]
synonym: "glial process" RELATED []
synonym: "glial projection" RELATED []
is_a: GO:0042995 ! cell projection
created_by: paola
creation_date: 2012-10-22T13:55:54Z

[Term]
id: GO:0097387
name: capitate projection
namespace: cellular_component
def: "Simple or compound process of epithelial glial cells with a spherical head that inserts into photoreceptor axons. Capitate projections have only been observed in Brachycera (flies)." [GOC:mc, PMID:3098431]
is_a: GO:0097386 ! glial cell projection
created_by: paola
creation_date: 2012-10-22T13:57:10Z

[Term]
id: GO:0097388
name: chemokine (C-C motif) ligand 19 production
namespace: biological_process
def: "The appearance of chemokine (C-C motif) ligand 19 (CCL19) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv]
synonym: "CCL19 production" EXACT []
synonym: "EBI1 ligand chemokine production" EXACT []
synonym: "ELC production" EXACT []
synonym: "macrophage inflammatory protein-3-beta production" EXACT []
synonym: "MIP-3-beta production" EXACT []
is_a: GO:0032602 ! chemokine production
created_by: paola
creation_date: 2012-10-23T07:54:10Z

[Term]
id: GO:0097389
name: chemokine (C-C motif) ligand 21 production
namespace: biological_process
def: "The appearance of chemokine (C-C motif) ligand 21 (CCL21) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv]
synonym: "CCL21 production" EXACT []
is_a: GO:0032602 ! chemokine production
created_by: paola
creation_date: 2012-10-23T07:56:26Z

[Term]
id: GO:0097390
name: chemokine (C-X-C motif) ligand 12 production
namespace: biological_process
def: "The appearance of chemokine (C-X-C motif) ligand 12 (CXCL12) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv]
synonym: "CXCL12 production" EXACT []
is_a: GO:0032602 ! chemokine production
created_by: paola
creation_date: 2012-10-23T07:57:28Z

[Term]
id: GO:0097391
name: chemokine (C-X-C motif) ligand 13 production
namespace: biological_process
def: "The appearance of chemokine (C-X-C motif) ligand 13 (CXCL13) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv]
synonym: "CXCL13 production" EXACT []
is_a: GO:0032602 ! chemokine production
created_by: paola
creation_date: 2012-10-23T07:58:28Z

[Term]
id: GO:0097392
name: chemokine (C-X-C motif) ligand 16 production
namespace: biological_process
def: "The appearance of chemokine (C-X-C motif) ligand 16 (CXCL16) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv]
synonym: "CXCL16 production" EXACT []
is_a: GO:0032602 ! chemokine production
created_by: paola
creation_date: 2012-10-23T07:59:43Z

[Term]
id: GO:0097393
name: telomeric repeat-containing RNA transcription
namespace: biological_process
def: "The synthesis of telomeric repeat-containing RNA from a DNA template. A telomere is a complex of DNA and proteins that seals the end of a chromosome." [GOC:al, PMID:22139915]
synonym: "TERRA transcription" EXACT [PMID:22139915]
is_a: GO:0006351 ! transcription, DNA-templated
created_by: paola
creation_date: 2012-10-23T10:06:17Z

[Term]
id: GO:0097394
name: telomeric repeat-containing RNA transcription from RNA pol II promoter
namespace: biological_process
def: "The synthesis of telomeric repeat-containing RNA from a DNA template by RNA Polymerase II (Pol II), originating at a Pol II promoter." [GOC:al, PMID:22139915]
synonym: "telomeric RNA transcription from Pol II promoter" RELATED []
synonym: "TERRA RNA transcription from RNA pol II promoter" RELATED [GOC:22139915]
is_a: GO:0006366 ! transcription from RNA polymerase II promoter
is_a: GO:0097393 ! telomeric repeat-containing RNA transcription
created_by: paola
creation_date: 2012-10-23T10:09:15Z

[Term]
id: GO:0097395
name: response to interleukin-32
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-32 stimulus." [GOC:pr]
synonym: "response to IL-32" EXACT []
is_a: GO:0034097 ! response to cytokine
created_by: paola
creation_date: 2012-10-23T13:21:16Z

[Term]
id: GO:0097396
name: response to interleukin-17
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-17 stimulus." [GOC:pr]
synonym: "response to IL-17" EXACT []
is_a: GO:0034097 ! response to cytokine
created_by: paola
creation_date: 2012-10-23T13:22:28Z

[Term]
id: GO:0097397
name: cellular response to interleukin-32
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-32 stimulus." [GOC:pr]
synonym: "cellular response to IL-32" EXACT []
is_a: GO:0071345 ! cellular response to cytokine stimulus
is_a: GO:0097395 ! response to interleukin-32
created_by: paola
creation_date: 2012-10-23T13:23:22Z

[Term]
id: GO:0097398
name: cellular response to interleukin-17
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-17 stimulus." [GOC:pr]
synonym: "cellular response to IL-17" EXACT []
is_a: GO:0071345 ! cellular response to cytokine stimulus
is_a: GO:0097396 ! response to interleukin-17
created_by: paola
creation_date: 2012-10-23T13:25:43Z

[Term]
id: GO:0097399
name: interleukin-32-mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of interleukin-32 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:ic, PMID:21602493]
synonym: "IL-32-mediated signaling pathway" EXACT []
synonym: "IL-32-mediated signalling pathway" EXACT []
synonym: "interleukin-32-mediated signalling pathway" EXACT []
is_a: GO:0019221 ! cytokine-mediated signaling pathway
relationship: part_of GO:0097397 ! cellular response to interleukin-32
created_by: paola
creation_date: 2012-10-23T13:27:22Z

[Term]
id: GO:0097400
name: interleukin-17-mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of interleukin-17 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:ic, PMID:21602493]
synonym: "IL-17-mediated signaling pathway" EXACT []
synonym: "IL-17-mediated signalling pathway" EXACT []
synonym: "interleukin-17-mediated signalling pathway" EXACT []
is_a: GO:0019221 ! cytokine-mediated signaling pathway
relationship: part_of GO:0097398 ! cellular response to interleukin-17
created_by: paola
creation_date: 2012-10-23T13:30:03Z

[Term]
id: GO:0097401
name: synaptic vesicle lumen acidification
namespace: biological_process
def: "The acidification of the synaptic vesicle lumen via transport of protons into the vesicle. The resulting electrochemical gradient powers neurotransmitter loading." [GOC:dsf, PMID:21172605, PMID:22875945]
subset: goslim_synapse
synonym: "synaptic vesicle lumen pH reduction" EXACT []
is_a: GO:0051452 ! intracellular pH reduction
is_a: GO:0070050 ! neuron cellular homeostasis
relationship: part_of GO:0016188 ! synaptic vesicle maturation
relationship: part_of GO:0099504 ! synaptic vesicle cycle
created_by: paola
creation_date: 2012-10-25T09:03:34Z

[Term]
id: GO:0097402
name: neuroblast migration
namespace: biological_process
def: "The orderly movement of a neuroblast from one site to another, often during the development of a multicellular organism or multicellular structure. A neuroblast is any cell that will divide and give rise to a neuron." [CL:0000031, GOC:jc, PMID:15543145]
is_a: GO:0016477 ! cell migration
created_by: paola
creation_date: 2012-10-29T08:24:37Z

[Term]
id: GO:0097403
name: cellular response to raffinose
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a raffinose stimulus." [GOC:al]
is_a: GO:0071322 ! cellular response to carbohydrate stimulus
is_a: GO:1901545 ! response to raffinose
created_by: paola
creation_date: 2012-10-29T10:30:46Z

[Term]
id: GO:0097404
name: succinate import into cell
namespace: biological_process
def: "The directed movement of succinate from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [GOC:al]
is_a: GO:0015744 ! succinate transport
is_a: GO:0098657 ! import into cell
created_by: paola
creation_date: 2012-10-29T11:17:44Z

[Term]
id: GO:0097405
name: malate import into cell
namespace: biological_process
def: "The directed movement of malate from outside of a cell into the intracellular region of a cell." [GOC:al]
is_a: GO:0015743 ! malate transport
is_a: GO:0098657 ! import into cell
created_by: paola
creation_date: 2012-10-29T11:18:48Z

[Term]
id: GO:0097406
name: malonic acid import into cell
namespace: biological_process
def: "The directed movement of malonic acid from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [GOC:al]
synonym: "malonate import into cell" RELATED []
is_a: GO:0098657 ! import into cell
is_a: GO:1900752 ! malonic acid transport
created_by: paola
creation_date: 2012-10-30T15:33:37Z

[Term]
id: GO:0097407
name: Bunina body
namespace: cellular_component
def: "Small granular inclusions (about 1-3 microns in diameter) found in the anterior horn cells, and appearing either singly or in a group. Sometimes they are arranged in small beaded chains. Bunina bodies express cystatin C and consist of electron-dense amorphous material that contains tubules or vesicular structures. The amorphous material frequently includes a cytoplasmic island containing neurofilaments and other micro-organelles." [NIF_Subcellular:nlx_subcell_20090101, PMID:18026741]
xref: NIF_Subcellular:nlx_subcell_20090101
is_a: GO:0016234 ! inclusion body
created_by: paola
creation_date: 2012-10-31T13:52:30Z

[Term]
id: GO:0097408
name: fibrillary inclusion
namespace: cellular_component
def: "Cellular inclusion consisting of circular areas filled with fine slender filaments about 10 nanometers in diameter, delimited by a wall of varying complexity (either a single continuous membrane or a tubular network consisting of a fine filamentous material giving the wall a honeycomb appearance). Fibrillary inclusions are found in the cytoplasm of giant cells of Dieters in the lateral vestibular nucleus of the rat; similar structures have been described in the ventral cochlear nucleus, spinal cord, and substantia nigra." [NIF_Subcellular:sao967812059]
xref: NIF_Subcellular:sao967812059
is_a: GO:0016234 ! inclusion body
created_by: paola
creation_date: 2012-10-31T13:53:58Z

[Term]
id: GO:0097409
name: glial cytoplasmic inclusion
namespace: cellular_component
def: "Non-membrane-bound cytoplasmic inclusions composed of 10-40 nm granule-coated fibrils. These inclusions have an abnormal accumulation of alpha-synuclein protein and are found in association with multiple system atrophy." [NIF_Subcellular:nlx_subcell_20090703, PMID:21562886, PMID:2559165]
synonym: "GCI" EXACT []
synonym: "Papp-Lantos body" RELATED []
xref: NIF_Subcellular:nlx_subcell_20090703
is_a: GO:0016234 ! inclusion body
created_by: paola
creation_date: 2012-10-31T13:55:11Z

[Term]
id: GO:0097410
name: hippocampal interneuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a hippocampal interneuron." [CL:1001569, GOC:jc, PMID:19655320]
is_a: GO:0021879 ! forebrain neuron differentiation
is_a: GO:0021895 ! cerebral cortex neuron differentiation
relationship: part_of GO:0021766 ! hippocampus development
created_by: paola
creation_date: 2012-11-04T10:58:28Z

[Term]
id: GO:0097411
name: hypoxia-inducible factor-1alpha signaling pathway
namespace: biological_process
def: "A series of molecular signals mediated by hypoxia-inducible factor (HIF1) in response to lowered oxygen levels (hypoxia). Under hypoxic conditions, the oxygen-sensitive alpha-subunit of hypoxia-inducible factor (HIF)-1 dimerizes with a HIF1-beta subunit (also called ARNT or aryl-hydrocarbon-receptor nuclear translocator), translocates to the nucleus and activates transcription of genes whose products participate in responding to hypoxia." [GOC:bf, GOC:jc, http://www.sabiosciences.com/pathway.php?sn=HIF1Alpha_Pathway]
synonym: "HIF1alpha pathway" EXACT []
synonym: "hypoxia-inducible factor signaling" EXACT [GOC:bf]
synonym: "hypoxia-inducible factor-1alpha signalling pathway" EXACT []
is_a: GO:0007165 ! signal transduction
relationship: part_of GO:0071456 ! cellular response to hypoxia
created_by: paola
creation_date: 2012-11-06T10:46:33Z

[Term]
id: GO:0097412
name: hyaline inclusion
namespace: cellular_component
def: "A glass-like, pale intracellular inclusion." [NIF_Subcellular:nlx_subcell_20090104]
synonym: "pale body" RELATED []
xref: NIF_Subcellular:nlx_subcell_20090104
is_a: GO:0016234 ! inclusion body
created_by: paola
creation_date: 2012-11-06T16:24:58Z

[Term]
id: GO:0097413
name: Lewy body
namespace: cellular_component
def: "Cytoplasmic, spherical inclusion commonly found in damaged neurons, and composed of abnormally phosphorylated, neurofilament proteins aggregated with ubiquitin and alpha-synuclein." [NIF_Subcellular:sao4933778419]
synonym: "cytoplasmic inclusion" RELATED []
xref: NIF_Subcellular:sao4933778419
is_a: GO:0016234 ! inclusion body
is_a: GO:0097458 ! neuron part
created_by: paola
creation_date: 2012-11-06T16:26:08Z

[Term]
id: GO:0097414
name: classical Lewy body
namespace: cellular_component
def: "Cytoplasmic inclusion, 5 to 15 micrometers in diameter, with a dense core surrounded by a halo of 10 to 20 nm wide radially oriented alpha-synuclein fibrils." [NIF_Subcellular:sao4749542545]
synonym: "brainstem Lewy body" RELATED []
xref: NIF_Subcellular:sao4749542545
is_a: GO:0097413 ! Lewy body
created_by: paola
creation_date: 2012-11-06T16:27:41Z

[Term]
id: GO:0097415
name: cortical Lewy body
namespace: cellular_component
def: "Cytoplasmic inclusion similar to a classical Lewy body but lacking a halo of protein fibrils." [NIF_Subcellular:sao4040591221]
xref: NIF_Subcellular:sao4040591221
is_a: GO:0097413 ! Lewy body
created_by: paola
creation_date: 2012-11-06T16:29:11Z

[Term]
id: GO:0097416
name: Lewy body-like hyaline inclusion
namespace: cellular_component
def: "Cytoplasmic inclusion found in neurons. It consists of filaments and granular materials, exhibits a dense core with a rough peripheral halo and lacks a limiting membrane. The filaments of these inclusions are composed of approximately 15-25 nm granule-coated fibrils in association with normal 10-nm neurofilaments." [NIF_Subcellular:nlx_subcell_20090105, PMID:18026741]
synonym: "LBHI" EXACT []
xref: NIF_Subcellular:nlx_subcell_20090105
is_a: GO:0016234 ! inclusion body
is_a: GO:0097458 ! neuron part
created_by: paola
creation_date: 2012-11-06T16:46:15Z

[Term]
id: GO:0097417
name: nematosome
namespace: cellular_component
def: "Cytoplasmic, ball-like inclusion resembling a nucleolus and consisting of a convoluted network of electron-opaque strands embedded in a less dense matrix. It measures approximately 0.9 microns and lacks a limiting membrane. Its strands (diameter = 400-600 A) appear to be made of an entanglement of tightly packed filaments and particles approximately 25-50 A thick. Cytochemical studies suggest the presence of nonhistone proteins and some RNA. Usually only one such structure is present in a cell, and it appears to occur in most ganglion cells. Although they can be seen anywhere in the cell body, nematosomes are typically located in the perinuclear cytoplasm, where they are often associated with smooth-surfaced and coated vesicles." [NIF_Subcellular:sao138430598, PMID:5458990]
xref: NIF_Subcellular:sao138430598
is_a: GO:0016234 ! inclusion body
created_by: paola
creation_date: 2012-11-06T16:47:56Z

[Term]
id: GO:0097418
name: neurofibrillary tangle
namespace: cellular_component
def: "Intracellular mass of paired, helically wound protein filaments (also called PHF) lying in the cytoplasm of neuronal cell bodies and neuritic cell processes. Neurofibrillary tangles contain an abnormally phosphorylated form of a microtubule-associated protein, tau. The shape of these inclusions may resemble a flame or a star." [NIF_Subcellular:nlx_subcell_20090201, NIF_Subcellular:nlx_subcell_20090202, NIF_Subcellular:sao2409833926]
comment: Neurofibrillary tangles have been found in aging population; their formation is increased in Alzheimer's disease patients (and in other neurological diseases) compared to normal controls (see PMID:848276 and PMID:8584267).
synonym: "flame-shaped neurofibrillary tangle" NARROW []
synonym: "star-shaped neurofibrillary tangle" NARROW []
xref: NIF_Subcellular:nlx_subcell_20090201
xref: NIF_Subcellular:nlx_subcell_20090202
xref: NIF_Subcellular:sao2409833926
is_a: GO:0016234 ! inclusion body
is_a: GO:0097458 ! neuron part
created_by: paola
creation_date: 2012-11-06T16:49:35Z

[Term]
id: GO:0097419
name: Pick body
namespace: cellular_component
def: "Cellular inclusion composed of numerous tau fibrils arranged in a disorderly array. Tau protein is a major component, though Pick bodies also contain ubiquitin, alpha-synuclein, and apolipoprotein E." [NIF_Subcellular:nlx_subcell_20090102]
xref: NIF_Subcellular:nlx_subcell_20090102
is_a: GO:0016234 ! inclusion body
created_by: paola
creation_date: 2012-11-06T20:57:02Z

[Term]
id: GO:0097420
name: skein-like inclusion
namespace: cellular_component
def: "Intracytoplasmic filamentous structure frequently encountered in preparations immunostained for ubiquitin." [NIF_Subcellular:nlx_subcell_20090103, PMID:18026741]
xref: NIF_Subcellular:nlx_subcell_20090103
is_a: GO:0016234 ! inclusion body
created_by: paola
creation_date: 2012-11-06T20:58:35Z

[Term]
id: GO:0097421
name: liver regeneration
namespace: biological_process
def: "The regrowth of lost or destroyed liver." [GOC:gap, PMID:19447520]
is_a: GO:0001889 ! liver development
is_a: GO:0031100 ! organ regeneration
created_by: paola
creation_date: 2012-11-07T10:22:43Z

[Term]
id: GO:0097422
name: tubular endosome
namespace: cellular_component
def: "A network of fine tubules in the vicinity of the Golgi complex and around the centriole." [NIF_Subcellular:sao1570660411, NIF_Subcellular:sao694815499, PMID:11896161]
synonym: "coated tip" RELATED []
xref: NIF_Subcellular:sao1570660411
xref: NIF_Subcellular:sao694815499
is_a: GO:0044440 ! endosomal part
created_by: paola
creation_date: 2012-11-07T13:36:26Z

[Term]
id: GO:0097423
name: mitochondrion-associated adherens complex
namespace: cellular_component
def: "An organelle arrangement comprised of the following elements: a mitochondrion positioned near the presynaptic membrane; an electron-dense mitochondrial plaque adjacent to the outer mitochondrial membrane that faces the presynaptic membrane; filament-like elements appearing to link the mitochondrial plaque to a cell-cell junction region (sometimes termed punctum adherens); tubular or vesicular-appearing membrane (also called vesicular chain) interposed among the filaments. Mitochondrion-associated adherens complexes were initially described in the dorsal horn of the spinal cord. They are found in calyces and other large terminals of the auditory brainstem, and in a variety of mammalian species including humans." [NIF_Subcellular:sao1933817066, PMID:20089910]
synonym: "MAC" RELATED []
synonym: "mitochondrial adhaerens complex" EXACT []
xref: NIF_Subcellular:sao1933817066
is_a: GO:0005575 ! cellular_component
relationship: has_part GO:0005739 ! mitochondrion
relationship: has_part GO:0005911 ! cell-cell junction
created_by: paola
creation_date: 2012-11-07T13:38:50Z

[Term]
id: GO:0097424
name: nucleolus-associated heterochromatin
namespace: cellular_component
def: "Dense particles of heterochromatin, consisting of a loosely twisted strand about 600 Angstrom thick, found associated with the nucleolus." [NIF_Subcellular:sao1210952635]
xref: NIF_Subcellular:sao1210952635
is_a: GO:0030874 ! nucleolar chromatin
created_by: paola
creation_date: 2012-11-07T13:43:17Z

[Term]
id: GO:0097425
name: smooth endoplasmic reticulum part
namespace: cellular_component
def: "Any constituent part of the smooth endoplasmic reticulum (also called smooth ER, or SER)." [NIF_Subcellular:sao184202831]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: goantislim_grouping
subset: gocheck_do_not_annotate
synonym: "SER subcomponent" RELATED [NIF_Subcellular:sao1842028314]
xref: NIF_Subcellular:sao184202831
is_a: GO:0044432 ! endoplasmic reticulum part
intersection_of: GO:0005575 ! cellular_component
intersection_of: part_of GO:0005790 ! smooth endoplasmic reticulum
relationship: part_of GO:0005790 ! smooth endoplasmic reticulum
created_by: paola
creation_date: 2012-11-07T13:45:14Z

[Term]
id: GO:0097426
name: glial filament
namespace: cellular_component
def: "An intermediate filament composed of glial fibrillary acidic protein (GFAP) and found in astrocytes." [NIF_Subcellular:sao-1863852493]
xref: NIF_Subcellular:sao-1863852493
xref: NIF_Subcellular:sao1863852493
is_a: GO:0005882 ! intermediate filament
created_by: paola
creation_date: 2012-11-07T14:59:55Z

[Term]
id: GO:0097427
name: microtubule bundle
namespace: cellular_component
def: "An arrangement of closely apposed microtubules running parallel to each other." [NIF_Subcellular:sao1872343973]
synonym: "microtubule fascicle" EXACT []
xref: NIF_Subcellular:sao1872343973
is_a: GO:0044430 ! cytoskeletal part
relationship: has_part GO:0005874 ! microtubule
created_by: paola
creation_date: 2012-11-07T15:01:27Z

[Term]
id: GO:0097428
name: protein maturation by iron-sulfur cluster transfer
namespace: biological_process
def: "The transfer of an assembled iron-sulfur cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein." [GOC:al, GOC:mah, PMID:11939799, PMID:18322036, PMID:21977977]
is_a: GO:0051604 ! protein maturation
created_by: paola
creation_date: 2012-11-15T09:59:06Z

[Term]
id: GO:0097429
name: amino acid ligation activity by nonribosomal peptide synthase
namespace: molecular_function
def: "Catalysis of the ligation of an amino acid to another amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate, carried out by a nonribosomal peptide synthase." [GOC:vw]
is_a: GO:0016881 ! acid-amino acid ligase activity
relationship: part_of GO:0019184 ! nonribosomal peptide biosynthetic process
created_by: paola
creation_date: 2012-11-16T12:34:22Z

[Term]
id: GO:0097430
name: copper ion import into ascospore-type prospore
namespace: biological_process
def: "The directed movement of copper ions into an ascospore-type prospore." [GOC:al, GOC:vw, PMID:21828039]
synonym: "copper ion transport into forespores" RELATED []
is_a: GO:0015677 ! copper ion import
is_a: GO:0015680 ! intracellular copper ion transport
created_by: paola
creation_date: 2012-11-16T12:37:05Z

[Term]
id: GO:0097431
name: mitotic spindle pole
namespace: cellular_component
def: "Either of the ends of a mitotic spindle, a spindle that forms as part of mitosis, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:vw]
is_a: GO:0000922 ! spindle pole
relationship: part_of GO:0072686 ! mitotic spindle
created_by: paola
creation_date: 2012-11-20T09:03:16Z

[Term]
id: GO:0097432
name: hippocampal pyramidal neuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a hippocampal pyramidal neuron, a pyramidal cell of the hippocampus." [CL:1001571, GOC:jc, PMID:19342486]
is_a: GO:0021859 ! pyramidal neuron differentiation
is_a: GO:0021879 ! forebrain neuron differentiation
is_a: GO:0021895 ! cerebral cortex neuron differentiation
created_by: paola
creation_date: 2012-11-22T09:33:31Z

[Term]
id: GO:0097433
name: dense body
namespace: cellular_component
def: "An electron dense body which may contain granules." [ISBN:0195065719, NIF_Subcellular:sao730872736]
xref: NIF_Subcellular:sao730872736
is_a: GO:0044444 ! cytoplasmic part
created_by: paola
creation_date: 2012-11-22T15:34:04Z

[Term]
id: GO:0097434
name: succinate:proton symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: succinate(out) + H+(out) = succinate(in) + H+(in)." [GOC:al, PMID:1293882]
synonym: "succinate:hydrogen symporter activity" EXACT []
is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity
is_a: GO:0015141 ! succinate transmembrane transporter activity
is_a: GO:0015295 ! solute:proton symporter activity
is_a: GO:0015296 ! anion:cation symporter activity
created_by: paola
creation_date: 2012-11-26T18:19:42Z

[Term]
id: GO:0097435
name: fibril organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of fibrils, insoluble fibrous aggregates consisting of polysaccharides and/or proteins." [GOC:pr]
synonym: "fibril organisation" EXACT []
is_a: GO:0030198 ! extracellular matrix organization
created_by: paola
creation_date: 2012-11-27T15:46:25Z

[Term]
id: GO:0097436
name: entry into dormancy
namespace: biological_process
def: "The dormancy process that results in entry into dormancy. Dormancy (sometimes called a dormant state) is a suspension of most physiological activity and growth that can be reactivated." [GOC:PO_curators, PO_REF:00009]
synonym: "induction of dormancy" EXACT []
is_a: GO:0022611 ! dormancy process
is_a: GO:0044767 ! single-organism developmental process
created_by: paola
creation_date: 2012-12-05T14:55:49Z

[Term]
id: GO:0097437
name: maintenance of dormancy
namespace: biological_process
def: "The dormancy process that results in an organism remaining in dormancy. Dormancy (sometimes called a dormant state) is a suspension of most physiological activity and growth that can be reactivated." [GOC:PO_curators, PO_REF:00009]
is_a: GO:0022611 ! dormancy process
is_a: GO:0044767 ! single-organism developmental process
created_by: paola
creation_date: 2012-12-05T15:00:24Z

[Term]
id: GO:0097438
name: exit from dormancy
namespace: biological_process
def: "The dormancy process that results in exit from dormancy. Dormancy (sometimes called a dormant state) is a suspension of most physiological activity and growth that can be reactivated." [GOC:PO_curators, PO_REF:00009]
synonym: "release from dormancy" EXACT []
is_a: GO:0022611 ! dormancy process
is_a: GO:0044767 ! single-organism developmental process
created_by: paola
creation_date: 2012-12-05T15:01:24Z

[Term]
id: GO:0097439
name: acquisition of desiccation tolerance
namespace: biological_process
def: "The process in which tolerance to severe drying is acquired, before entering into a dry, either dormant or quiescent state." [GOC:PO_curators]
is_a: GO:0022611 ! dormancy process
is_a: GO:0044767 ! single-organism developmental process
created_by: paola
creation_date: 2012-12-05T15:09:52Z

[Term]
id: GO:0097440
name: apical dendrite
namespace: cellular_component
def: "A dendrite that emerges near the apical pole of a neuron. In bipolar neurons, apical dendrites are located on the opposite side of the soma from the axon." [NIF_Subcellular:sao273773228]
xref: NIF_Subcellular:sao273773228
is_a: GO:0030425 ! dendrite
created_by: paola
creation_date: 2012-12-06T13:45:18Z

[Term]
id: GO:0097441
name: basilar dendrite
namespace: cellular_component
def: "A dendrite that emerges near the basal pole of a neuron. In bipolar neurons, basal dendrites are either on the same side of the soma as the axon, or project toward the axon." [NIF_Subcellular:sao1079900774]
xref: NIF_Subcellular:sao1079900774
is_a: GO:0030425 ! dendrite
created_by: paola
creation_date: 2012-12-06T13:46:28Z

[Term]
id: GO:0097442
name: CA3 pyramidal cell dendrite
namespace: cellular_component
def: "A dendrite of a hippocampal CA3 pyramidal cell." [NIF_Subcellular:nlx_subcell_1005001]
xref: NIF_Subcellular:nlx_subcell_1005001
is_a: GO:0030425 ! dendrite
created_by: paola
creation_date: 2012-12-06T13:47:23Z

[Term]
id: GO:0097443
name: sorting endosome
namespace: cellular_component
def: "A multivesicular body surrounded by and connected with multiple tubular compartments with associated vesicles." [NIF_Subcellular:sao1028571114]
synonym: "MVB-tubule complex" RELATED []
xref: NIF_Subcellular:sao1028571114
is_a: GO:0005768 ! endosome
created_by: paola
creation_date: 2012-12-06T14:04:14Z

[Term]
id: GO:0097444
name: spine apparatus
namespace: cellular_component
def: "A specialization of the endomembrane system found in some classes of neuron spines consisting of two or more closely apposed lamellae with interspersed electron dense material.  The endomembrane component is continuous with the smooth endoplasmic reticulum." [NIF_Subcellular:sao725931194, PMID:20400711, PMID:8987748]
subset: goslim_synapse
synonym: "dense material" NARROW [NIF_Subcellular:sao1004601938]
xref: NIF_Subcellular:sao725931194
is_a: GO:0044463 ! cell projection part
is_a: GO:0097458 ! neuron part
relationship: part_of GO:0012505 ! endomembrane system
relationship: part_of GO:0044309 ! neuron spine
created_by: paola
creation_date: 2012-12-06T14:05:58Z

[Term]
id: GO:0097445
name: presynaptic active zone dense projection
namespace: cellular_component
def: "Electron dense projection extending from the cytomatrix into the cytoplasm on which synaptic vesicles are tethered." [NIF_Subcellular:sao494258938, PMID:15381754]
synonym: "active zone dense projection" EXACT []
synonym: "pre-synaptic active zone dense projection" EXACT []
xref: NIF_Subcellular:sao494258938
is_a: GO:0044456 ! synapse part
is_a: GO:0097458 ! neuron part
relationship: part_of GO:0048786 ! presynaptic active zone
created_by: paola
creation_date: 2012-12-06T14:08:21Z

[Term]
id: GO:0097446
name: protein localization to eisosome filament
namespace: biological_process
def: "A process in which a protein is transported to, and/or maintained in, a specific location in a eisosome filament (also called linear eisosome), a filamentous cortical structure formed, in S. pombe, by the eisosome component Pil1." [GOC:mah, GOC:vw, PMID:22869600, PMID:23722945]
synonym: "protein localization to linear eisosome" EXACT []
is_a: GO:0044380 ! protein localization to cytoskeleton
is_a: GO:0072697 ! protein localization to cell cortex
created_by: paola
creation_date: 2012-12-17T09:37:49Z

[Term]
id: GO:0097447
name: dendritic tree
namespace: cellular_component
def: "The entire complement of dendrites for a neuron, consisting of each primary dendrite and all its branches." [NIF_Subcellular:sao172297168]
xref: NIF_Subcellular:sao172297168
is_a: GO:0097458 ! neuron part
relationship: has_part GO:0030425 ! dendrite
created_by: paola
creation_date: 2012-12-17T12:31:49Z

[Term]
id: GO:0097448
name: spine mat
namespace: cellular_component
def: "A configuration of neuron spines found on ciliary ganglion neurons in the embryonic and adult brain consisting of patches of closely spaced spines lying flat against the soma." [NIF_Subcellular:sao2128156969, PMID:10818137]
xref: NIF_Subcellular:sao2128156969
is_a: GO:0097458 ! neuron part
relationship: has_part GO:0044309 ! neuron spine
created_by: paola
creation_date: 2012-12-17T12:34:16Z

[Term]
id: GO:0097449
name: astrocyte projection
namespace: cellular_component
def: "A prolongation or process extending from the soma of an astrocyte and wrapping around neurons." [NIF_Subcellular:sao1630537580]
synonym: "astrocyte process" EXACT []
synonym: "peripheral astrocyte process" RELATED [NIF_Subcellular:sao1573004591, PMID:12445894]
synonym: "vellous process" RELATED [NIF_Subcellular:sao1189060993]
xref: NIF_Subcellular:sao1630537580
is_a: GO:0097386 ! glial cell projection
created_by: paola
creation_date: 2012-12-17T13:29:55Z

[Term]
id: GO:0097450
name: astrocyte end-foot
namespace: cellular_component
def: "Terminal process of astrocyte abutting non-neuronal surfaces in the brain." [NIF_Subcellular:sao388182739]
synonym: "astrocyte endfoot" EXACT []
xref: NIF_Subcellular:sao388182739
is_a: GO:0097449 ! astrocyte projection
created_by: paola
creation_date: 2012-12-17T13:33:55Z

[Term]
id: GO:0097451
name: glial limiting end-foot
namespace: cellular_component
def: "Terminal process of astrocyte that extends to the surface of the central nervous system. Together, glial limiting end-feet form the glial limiting membrane or glia limitans." [NIF_Subcellular:sao181458425]
synonym: "glial limiting endfoot" EXACT []
xref: NIF_Subcellular:sao181458425
is_a: GO:0097450 ! astrocyte end-foot
created_by: paola
creation_date: 2012-12-17T13:36:34Z

[Term]
id: GO:0097452
name: GAIT complex
namespace: cellular_component
def: "A protein complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. The complex binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs and suppresses their translation by blocking the recruitment of the 43S ribosomal complex to m7G cap-bound eIF4G. In humans it includes RPL13A, EPRS, SYNCRIP and GAPDH; mouse complexes lack SYNCRIP." [GOC:br, PMID:15479637, PMID:23071094]
synonym: "gamma interferon-activated inhibitor of translation complex" EXACT []
synonym: "IFN-gamma-activated inhibitor of translation complex" EXACT []
is_a: GO:0043234 ! protein complex
created_by: paola
creation_date: 2012-12-19T09:32:25Z

[Term]
id: GO:0097453
name: mesaxon
namespace: cellular_component
def: "Portion of the ensheathing process (either myelin or non-myelin) where the enveloping lips of the ensheathing cell come together so that their apposed plasma membranes run parallel to each other, separated by a cleft 12 nm wide." [ISBN:01950657191, NIF_Subcellular:sao2127666702]
synonym: "mesaxon of Schwann cell" NARROW []
xref: NIF_Subcellular:sao2127666702
is_a: GO:1990015 ! ensheathing process
created_by: paola
creation_date: 2012-12-19T12:59:13Z

[Term]
id: GO:0097454
name: Schwann cell microvillus
namespace: cellular_component
def: "Small finger-like extension of a Schwann cell that contacts the nodal membrane." [NIF_Subcellular:sao1890444066, PMID:15988042]
xref: NIF_Subcellular:sao1890444066
is_a: GO:0005902 ! microvillus
is_a: GO:0097386 ! glial cell projection
created_by: paola
creation_date: 2012-12-19T13:01:02Z

[Term]
id: GO:0097455
name: spiny bracelet of Nageotte
namespace: cellular_component
def: "Paranodal terminations of Schwann cells that do not directly contact the paranodal axon membrane. Usually found in thicker myelin." [NIF_Subcellular:sao937871668, PMID:15988042]
xref: NIF_Subcellular:sao937871668
is_a: GO:0097386 ! glial cell projection
created_by: paola
creation_date: 2012-12-19T13:02:33Z

[Term]
id: GO:0097456
name: terminal loop
namespace: cellular_component
def: "Portion of myelin-forming Schwann cell consisting of terminal cytoplasmic extensions adhered to the axon at the beginning and end of the myelin sheath." [NIF_Subcellular:sao924713546]
synonym: "terminal loop of Schwann cell" EXACT []
xref: NIF_Subcellular:sao924713546
is_a: GO:0097386 ! glial cell projection
created_by: paola
creation_date: 2012-12-19T13:04:06Z

[Term]
id: GO:0097457
name: hippocampal mossy fiber
namespace: cellular_component
def: "Axon of dentate gyrus granule cell projecting to hippocampal area CA3, characterized by expansions (mossy fiber expansions) giving the fibers a mossy appearance. These unmyelinated axons were first described by Ramon y Cajal." [NIF_Subcellular:nlx_subcell_100312, PMID:17765709]
xref: NIF_Subcellular:nlx_subcell_100312
is_a: GO:0044302 ! dentate gyrus mossy fiber
created_by: paola
creation_date: 2012-12-19T16:51:57Z

[Term]
id: GO:0097458
name: neuron part
namespace: cellular_component
def: "Any constituent part of a neuron, the basic cellular unit of nervous tissue. A typical neuron consists of a cell body (often called the soma), an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." [GOC:pr, http://en.wikipedia.org/wiki/Neuron]
subset: goantislim_grouping
subset: gocheck_do_not_annotate
is_a: GO:0044464 ! cell part
created_by: paola
creation_date: 2012-12-19T16:53:50Z

[Term]
id: GO:0097459
name: iron ion import into cell
namespace: biological_process
def: "The directed movement of iron ions from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [GOC:mah, PMID:8321236]
synonym: "iron import into cell" RELATED [GOC:mah]
is_a: GO:0097286 ! iron ion import
is_a: GO:0098659 ! inorganic cation import into cell
created_by: paola
creation_date: 2012-12-20T08:29:00Z

[Term]
id: GO:0097460
name: ferrous iron import into cell
namespace: biological_process
def: "The directed movement of ferrous iron (Fe(II) or Fe2+) ions from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [GOC:mah, PMID:8321236]
synonym: "ferrous ion import into cell" EXACT [GOC:mah]
is_a: GO:0070627 ! ferrous iron import
is_a: GO:0097459 ! iron ion import into cell
created_by: paola
creation_date: 2012-12-20T08:31:05Z

[Term]
id: GO:0097461
name: ferric iron import into cell
namespace: biological_process
def: "The directed movement of ferric iron (Fe(III) or Fe3+) ions from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [GOC:mah, PMID:8321236]
synonym: "ferric ion import into cell" EXACT [GOC:mah]
is_a: GO:0033216 ! ferric iron import
is_a: GO:0097459 ! iron ion import into cell
created_by: paola
creation_date: 2012-12-20T08:33:03Z

[Term]
id: GO:0097462
name: Lewy neurite
namespace: cellular_component
def: "Elongated neuronal process, often with side branches and more than one branching point, described in brains of patients with Parkinson's disease. Lewy neurites stain positively for ubiquitin in brainstem and forebrain regions affected in Parkinson's disease." [NIF_Subcellular:sao601362597]
xref: NIF_Subcellular:sao601362597
is_a: GO:0043005 ! neuron projection
created_by: paola
creation_date: 2012-12-21T07:57:58Z

[Term]
id: GO:0097463
name: gemmule
namespace: cellular_component
def: "Spine-like process found on some neurons, e.g., periglomerular cells of olfactory cortex." [NIF_Subcellular:nlx_subcell_1005003]
xref: NIF_Subcellular:nlx_subcell_1005003
is_a: GO:0043005 ! neuron projection
created_by: paola
creation_date: 2012-12-21T07:59:04Z

[Term]
id: GO:0097464
name: thorny excrescence
namespace: cellular_component
def: "Large complex spine protruding from a dendrite. Each excrescence is formed by a cluster of spine heads." [NIF_Subcellular:nlx_467, PMID:730852]
xref: NIF_Subcellular:nlx_467
is_a: GO:0043197 ! dendritic spine
created_by: paola
creation_date: 2012-12-21T08:00:13Z

[Term]
id: GO:0097465
name: somatic spine
namespace: cellular_component
def: "Spine emanating from the cell soma of a neuron." [NIF_Subcellular:sao2048514053]
xref: NIF_Subcellular:sao2048514053
is_a: GO:0044309 ! neuron spine
created_by: paola
creation_date: 2012-12-21T08:02:37Z

[Term]
id: GO:0097466
name: glycoprotein ERAD pathway
namespace: biological_process
def: "An ERAD pathway whereby endoplasmic reticulum (ER)-resident glycoproteins are targeted for degradation. Includes differential processing of the glycoprotein sugar chains, retrotranslocation to the cytosol and degradation by the ubiquitin-proteasome pathway. A glycoprotein is a compound in which a carbohydrate component is covalently bound to a protein component." [GOC:al, GOC:bf, PMID:16079177]
synonym: "ER-associated glycoprotein degradation" EXACT [GOC:bf]
synonym: "glycoprotein ERAD" EXACT [GOC:bf]
synonym: "gpERAD" EXACT [PMID:25092655]
synonym: "misfolded or incompletely synthesized glycoprotein catabolic process" BROAD []
is_a: GO:0006516 ! glycoprotein catabolic process
is_a: GO:0036503 ! ERAD pathway
is_a: GO:1904587 ! response to glycoprotein
created_by: paola
creation_date: 2013-02-05T16:37:13Z

[Term]
id: GO:0097467
name: type III terminal bouton
namespace: cellular_component
def: "Terminal inflated portion of the axon of a non-glutamatergic neuron, containing the specialized apparatus necessary to release neurotransmitters at a regulatory synapse. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it. Type III terminal boutons are larger than type II ones." [GOC:mc, PMID:10218156]
synonym: "type III terminal button" EXACT []
is_a: GO:0043195 ! terminal bouton
created_by: paola
creation_date: 2013-02-06T09:39:18Z

[Term]
id: GO:0097468
name: programmed cell death in response to reactive oxygen species
namespace: biological_process
def: "Cell death resulting from activation of endogenous cellular processes and occurring as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:mtg_apoptosis]
synonym: "PCD in response to oxidative stress" BROAD []
synonym: "PCD in response to reactive oxygen species" EXACT []
synonym: "programmed cell death in response to oxidative stress" BROAD []
synonym: "reactive oxygen species-mediated PCD" EXACT []
synonym: "reactive oxygen species-mediated programmed cell death" EXACT []
is_a: GO:0012501 ! programmed cell death
is_a: GO:0036473 ! cell death in response to oxidative stress
relationship: part_of GO:0034614 ! cellular response to reactive oxygen species
created_by: paola
creation_date: 2013-02-19T10:03:36Z

[Term]
id: GO:0097469
name: obsolete cyclin-dependent protein tyrosine kinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. This reaction requires the binding of a regulatory cyclin subunit." [GOC:al, GOC:vw, PMID:1372994]
comment: This term was made obsolete because it was added in error; the specific activity it refers to has never been observed.
synonym: "cyclin-dependent protein tyrosine kinase activity" EXACT []
is_obsolete: true
created_by: paola
creation_date: 2013-02-19T12:42:11Z

[Term]
id: GO:0097470
name: ribbon synapse
namespace: cellular_component
def: "Type of synapse characterized by an electron-dense ribbon, lamella (bar) or spherical body in the presynaptic process cytoplasm." [NIF_Subcellular:sao1884931180]
xref: NIF_Subcellular:sao1884931180
is_a: GO:0045202 ! synapse
created_by: paola
creation_date: 2013-02-21T07:40:01Z

[Term]
id: GO:0097471
name: mossy fiber rosette
namespace: cellular_component
def: "A synapse of a mossy fiber onto the dendrite of a granule cell; each mossy fiber can have up to 50 rosettes." [http://en.wikipedia.org/wiki/Mossy_fiber_(cerebellum), NIF_Subcellular:nlx_subcell_091021]
xref: NIF_Subcellular:nlx_subcell_091021
is_a: GO:0045202 ! synapse
created_by: paola
creation_date: 2013-02-21T07:42:52Z

[Term]
id: GO:0097472
name: cyclin-dependent protein kinase activity
namespace: molecular_function
def: "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK)." [GOC:pr]
is_a: GO:0004672 ! protein kinase activity
relationship: has_part GO:0030332 ! cyclin binding
relationship: part_of GO:0051726 ! regulation of cell cycle
created_by: paola
creation_date: 2013-03-06T13:46:04Z

[Term]
id: GO:0097473
name: retinal rod cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a retinal rod cell, one of the two photoreceptor cell types of the vertebrate retina." [CL:0000604, GOC:jc, PMID:17202487]
synonym: "rod photoreceptor apoptotic process" EXACT []
is_a: GO:0051402 ! neuron apoptotic process
is_a: GO:1990009 ! retinal cell apoptotic process
created_by: paola
creation_date: 2013-03-21T09:44:45Z

[Term]
id: GO:0097474
name: retinal cone cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a retinal cone cell, one of the two photoreceptor cell types of the vertebrate retina." [CL:0000573, GOC:jc]
synonym: "cone photoreceptor apoptotic process" EXACT []
is_a: GO:0051402 ! neuron apoptotic process
is_a: GO:1990009 ! retinal cell apoptotic process
created_by: paola
creation_date: 2013-03-21T09:46:22Z

[Term]
id: GO:0097475
name: motor neuron migration
namespace: biological_process
def: "The orderly movement of a motor neuron from one site to another. A motor neuron is an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement." [CL:0000100, GOC:yaf, PMID:20711475]
is_a: GO:0001764 ! neuron migration
created_by: paola
creation_date: 2013-04-23T13:00:46Z

[Term]
id: GO:0097476
name: spinal cord motor neuron migration
namespace: biological_process
def: "The orderly movement of a spinal cord motor neuron from one site to another. A spinal cord motor neuron is a motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement." [CL:0011001, GOC:yaf, PMID:20711475]
is_a: GO:0097475 ! motor neuron migration
created_by: paola
creation_date: 2013-04-23T13:03:46Z

[Term]
id: GO:0097477
name: lateral motor column neuron migration
namespace: biological_process
def: "The orderly movement of a lateral motor column neuron from one site to another. A lateral motor column neuron is a motor neuron that is generated only on limb levels and send axons into the limb mesenchyme." [CL:0011002, GOC:yaf, PMID:20711475]
is_a: GO:0097476 ! spinal cord motor neuron migration
created_by: paola
creation_date: 2013-04-23T13:05:32Z

[Term]
id: GO:0097478
name: leaflet of membrane bilayer
namespace: cellular_component
def: "Any of the two layers of lipid molecules that constitute a membrane." [GOC:cjm]
synonym: "membrane leaflet" EXACT []
is_a: GO:0044425 ! membrane part
created_by: paola
creation_date: 2013-05-07T14:24:37Z

[Term]
id: GO:0097479
name: synaptic vesicle localization
namespace: biological_process
def: "Any process in which a synaptic vesicle or vesicles are transported to, and/or maintained in, a specific location." [GOC:pr]
synonym: "establishment and maintenance of synaptic vesicle localization" EXACT []
synonym: "establishment and maintenance of synaptic vesicle position" EXACT []
synonym: "synaptic vesicle localisation" EXACT []
is_a: GO:0051648 ! vesicle localization
created_by: paola
creation_date: 2013-05-22T14:29:55Z

[Term]
id: GO:0097480
name: establishment of synaptic vesicle localization
namespace: biological_process
def: "The directed movement of a synaptic vesicle or vesicles to a specific location." [GOC:pr]
synonym: "establishment of synaptic vesicle localisation" EXACT []
is_a: GO:0051650 ! establishment of vesicle localization
relationship: part_of GO:0097479 ! synaptic vesicle localization
created_by: paola
creation_date: 2013-05-22T14:32:12Z

[Term]
id: GO:0097481
name: neuronal postsynaptic density
namespace: cellular_component
def: "A postsynaptic density that is part of a neuron." [GOC:BHF, GOC:pr, GOC:rl]
subset: goslim_synapse
synonym: "neuron postsynaptic density" EXACT []
is_a: GO:0014069 ! postsynaptic density
is_a: GO:0044463 ! cell projection part
is_a: GO:0097458 ! neuron part
created_by: paola
creation_date: 2013-07-02T09:44:28Z

[Term]
id: GO:0097482
name: muscle cell postsynaptic density
namespace: cellular_component
def: "A postsynaptic density that is part of a muscle cell." [GOC:pr]
synonym: "muscle fiber postsynaptic density" EXACT []
is_a: GO:0014069 ! postsynaptic density
created_by: paola
creation_date: 2013-07-02T09:47:40Z

[Term]
id: GO:0097483
name: glial cell postsynaptic density
namespace: cellular_component
def: "A postsynaptic density that is part of a glial cell." [GOC:pr]
is_a: GO:0014069 ! postsynaptic density
created_by: paola
creation_date: 2013-07-02T09:48:36Z

[Term]
id: GO:0097484
name: dendrite extension
namespace: biological_process
def: "Long distance growth of a single dendrite involved in cellular development." [GOC:BHF, GOC:rl]
is_a: GO:1990138 ! neuron projection extension
created_by: paola
creation_date: 2013-07-08T09:52:31Z

[Term]
id: GO:0097485
name: neuron projection guidance
namespace: biological_process
def: "The process in which the migration of a neuron projection is directed to a specific target site in response to a combination of attractive and repulsive cues." [GOC:BHF, GOC:rl, PMID:22790009]
synonym: "neurite guidance" NARROW []
synonym: "neuron process guidance" EXACT []
synonym: "neuron protrusion guidance" EXACT []
synonym: "neuronal cell projection guidance" EXACT []
is_a: GO:0006928 ! movement of cell or subcellular component
relationship: part_of GO:0006935 ! chemotaxis
relationship: part_of GO:0048812 ! neuron projection morphogenesis
created_by: paola
creation_date: 2013-07-08T13:32:37Z

[Term]
id: GO:0097486
name: multivesicular body lumen
namespace: cellular_component
def: "The volume enclosed by the outermost membrane of a multivesicular body." [GOC:pde, PMID:21183070]
is_a: GO:0031906 ! late endosome lumen
relationship: part_of GO:0005771 ! multivesicular body
created_by: paola
creation_date: 2013-07-08T20:32:56Z

[Term]
id: GO:0097487
name: multivesicular body, internal vesicle
namespace: cellular_component
def: "A membrane-bounded vesicle wholly contained within a multivesicular body." [GOC:pde, PMID:21183070]
is_a: GO:0016023 ! cytoplasmic, membrane-bounded vesicle
is_a: GO:0044440 ! endosomal part
relationship: part_of GO:0005771 ! multivesicular body
created_by: paola
creation_date: 2013-07-08T20:34:51Z

[Term]
id: GO:0097488
name: multivesicular body, internal vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a multivesicular body internal vesicle." [GOC:pde, PMID:21183070]
is_a: GO:0012506 ! vesicle membrane
is_a: GO:0044433 ! cytoplasmic vesicle part
is_a: GO:0044440 ! endosomal part
is_a: GO:0098588 ! bounding membrane of organelle
relationship: part_of GO:0097487 ! multivesicular body, internal vesicle
created_by: paola
creation_date: 2013-07-08T20:36:33Z

[Term]
id: GO:0097489
name: multivesicular body, internal vesicle lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of the multivesicular body internal vesicle." [GOC:pde, PMID:21183070]
is_a: GO:0005775 ! vacuolar lumen
is_a: GO:0031983 ! vesicle lumen
is_a: GO:0044433 ! cytoplasmic vesicle part
is_a: GO:0044440 ! endosomal part
relationship: part_of GO:0097487 ! multivesicular body, internal vesicle
created_by: paola
creation_date: 2013-07-08T20:38:36Z

[Term]
id: GO:0097490
name: sympathetic neuron projection extension
namespace: biological_process
def: "Long distance growth of a single sympathetic neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:BHF, GOC:rl, PMID:22790009]
synonym: "sympathetic neurite extension" NARROW []
synonym: "sympathetic neuron process extension" EXACT []
synonym: "sympathetic neuron protrusion extension" EXACT []
synonym: "sympathetic neuronal cell projection extension" EXACT []
is_a: GO:1990138 ! neuron projection extension
created_by: paola
creation_date: 2013-07-10T11:47:53Z

[Term]
id: GO:0097491
name: sympathetic neuron projection guidance
namespace: biological_process
def: "The process in which the migration of a sympathetic neuron projection is directed to a specific target site in response to a combination of attractive and repulsive cues." [GOC:BHF, GOC:rl, PMID:22790009]
synonym: "sympathetic neurite guidance" NARROW []
synonym: "sympathetic neuron process guidance" EXACT []
synonym: "sympathetic neuron protrusion guidance" EXACT []
synonym: "sympathetic neuronal cell projection guidance" EXACT []
is_a: GO:0097485 ! neuron projection guidance
created_by: paola
creation_date: 2013-07-10T11:49:21Z

[Term]
id: GO:0097492
name: sympathetic neuron axon guidance
namespace: biological_process
def: "The chemotaxis process that directs the migration of a sympathetic neuron axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [GOC:BHF, GOC:rl, PMID:22790009]
synonym: "sympathetic neuron axon chemotaxis" RELATED []
synonym: "sympathetic neuron axon growth cone guidance" NARROW []
synonym: "sympathetic neuron axon pathfinding" EXACT []
is_a: GO:0007411 ! axon guidance
created_by: paola
creation_date: 2013-07-10T11:50:52Z

[Term]
id: GO:0097493
name: structural molecule activity conferring elasticity
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell, providing elasticity and recoiling." [GOC:BHF, GOC:rl, PMID:23283722]
is_a: GO:0005198 ! structural molecule activity
created_by: paola
creation_date: 2013-07-26T09:47:26Z

[Term]
id: GO:0097494
name: regulation of vesicle size
namespace: biological_process
def: "Any process that modulates the size of a vesicle." [GOC:pm, PMID:20007772]
is_a: GO:0032535 ! regulation of cellular component size
created_by: paola
creation_date: 2013-08-06T11:48:51Z

[Term]
id: GO:0097495
name: H-NS-Hha complex
namespace: cellular_component
def: "A trimeric protein complex made up of an H-NS homodimer and an Hha monomer. In Enterobacteriaceae, this complex negatively regulates transcription of a range of genes." [GOC:bhm, PMID:21600204]
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part
relationship: has_part GO:1990121 ! H-NS complex
relationship: part_of GO:0005829 ! cytosol
created_by: paola
creation_date: 2013-08-08T14:37:33Z

[Term]
id: GO:0097496
name: blood vessel lumen ensheathment
namespace: biological_process
def: "A blood vessel lumenization process that occurs by blood vessel endothelial cells delaminating and aligning along the inner surface of an existing luminal space, extending the open ended lumen, and joining to other blood vessels to form a complete blood vessel." [GOC:dgh, PMID:23698350]
is_a: GO:0072554 ! blood vessel lumenization
created_by: paola
creation_date: 2013-08-12T13:46:45Z

[Term]
id: GO:0097497
name: blood vessel endothelial cell delamination
namespace: biological_process
def: "The process of negative regulation of cell adhesion that results in blood vessel endothelial cells splitting off from an existing endothelial sheet." [GOC:dgh, PMID:23698350]
is_a: GO:0060232 ! delamination
created_by: paola
creation_date: 2013-08-12T13:48:34Z

[Term]
id: GO:0097498
name: endothelial tube lumen extension
namespace: biological_process
def: "Any endothelial tube morphogenesis process by which the tube is increased in length." [GOC:dgh, PMID:23698350]
is_a: GO:0061154 ! endothelial tube morphogenesis
created_by: paola
creation_date: 2013-08-12T13:49:54Z

[Term]
id: GO:0097499
name: protein localization to nonmotile primary cilium
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a nonmotile primary cilium." [GOC:kmv, PMID:23128241]
is_a: GO:0061512 ! protein localization to cilium
created_by: paola
creation_date: 2013-08-13T12:16:26Z

[Term]
id: GO:0097500
name: receptor localization to nonmotile primary cilium
namespace: biological_process
def: "A process in which a receptor is transported to, or maintained in, a location within a nonmotile primary cilium." [GOC:kmv, PMID:23128241]
is_a: GO:0097499 ! protein localization to nonmotile primary cilium
is_a: GO:1903441 ! protein localization to ciliary membrane
created_by: paola
creation_date: 2013-08-13T12:17:34Z

[Term]
id: GO:0097501
name: stress response to metal ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a metal ion stimulus." [GOC:kmv]
synonym: "response to excess metal ion" RELATED []
synonym: "response to metal ion stress" EXACT []
synonym: "response to metal ion toxicity" RELATED []
synonym: "response to metal toxicity" RELATED []
is_a: GO:0006950 ! response to stress
is_a: GO:0010038 ! response to metal ion
created_by: paola
creation_date: 2013-08-15T10:37:45Z

[Term]
id: GO:0097502
name: mannosylation
namespace: biological_process
def: "The covalent attachment of a mannose residue to a substrate molecule." [GOC:cjm]
is_a: GO:0070085 ! glycosylation
created_by: paola
creation_date: 2013-09-20T09:47:40Z

[Term]
id: GO:0097503
name: sialylation
namespace: biological_process
def: "The covalent attachment of sialic acid to a substrate molecule." [GOC:cjm]
is_a: GO:0043412 ! macromolecule modification
created_by: paola
creation_date: 2013-09-20T09:53:10Z

[Term]
id: GO:0097504
name: Gemini of coiled bodies
namespace: cellular_component
def: "Nuclear bodies frequently found near or associated with Cajal bodies (also called coiled bodies or CBs). Gemini of coiled bodies, or 'gems', are similar in size and shape to CBs, and often indistinguishable under the microscope. Unlike CBs, gems do not contain small nuclear ribonucleoproteins (snRNPs); they contain a protein called survivor of motor neurons (SMN) whose function relates to snRNP biogenesis. Gems are believed to assist CBs in snRNP biogenesis, and to play a role in the etiology of spinal muscular atrophy (SMA)." [GOC:pr, http://en.wikipedia.org/wiki/Cell_nucleus#Cajal_bodies_and_gems, PMID:11031238, PMID:9683623]
synonym: "Gems" EXACT []
is_a: GO:0016604 ! nuclear body
created_by: paola
creation_date: 2013-09-24T15:20:12Z

[Term]
id: GO:0097505
name: Rad6-Rad18 complex
namespace: cellular_component
def: "A ubiquitin ligase complex found to be involved in post-replicative bypass of UV-damaged DNA and UV mutagenesis. In S. cerevisiae, the complex contains the ubiquitin conjugating enzyme Rad6 and Rad18, a protein containing a RING finger motif and a nucleotide binding motif. The yeast Rad6-Rad18 heterodimer has ubiquitin conjugating activity, binds single-stranded DNA, and possesses single-stranded DNA-dependent ATPase activity." [GOC:jd, PMID:9287349]
is_a: GO:0000151 ! ubiquitin ligase complex
created_by: paola
creation_date: 2013-09-26T13:42:58Z

[Term]
id: GO:0097506
name: deaminated base DNA N-glycosylase activity
namespace: molecular_function
def: "DNA N-glycosylase activity acting on deaminated bases." [GOC:al, PMID:18789404]
synonym: "deaminated base DNA glycosylase activity" EXACT []
synonym: "DNA glycosylase activity acting on deaminated bases" EXACT []
is_a: GO:0019104 ! DNA N-glycosylase activity
created_by: paola
creation_date: 2013-09-26T16:00:40Z

[Term]
id: GO:0097507
name: hypoxanthine DNA N-glycosylase activity
namespace: molecular_function
def: "DNA N-glycosylase activity acting on deaminated adenine (hypoxanthine)." [GOC:al, PMID:18789404]
synonym: "hypoxanthine-DNA glycosylase activity" RELATED []
is_a: GO:0097506 ! deaminated base DNA N-glycosylase activity
created_by: paola
creation_date: 2013-09-26T16:02:08Z

[Term]
id: GO:0097508
name: xanthine DNA N-glycosylase activity
namespace: molecular_function
def: "DNA N-glycosylase activity acting on deaminated guanine (xanthine)." [GOC:al, PMID:18789404]
synonym: "xanthine-DNA glycosylase activity" RELATED []
is_a: GO:0097506 ! deaminated base DNA N-glycosylase activity
created_by: paola
creation_date: 2013-09-26T16:03:10Z

[Term]
id: GO:0097509
name: oxanine DNA N-glycosylase activity
namespace: molecular_function
def: "DNA N-glycosylase activity acting on deaminated guanine where the resulting base (oxanine) is generated by NO- or HNO2-induced nitrosative deamination." [GOC:al, PMID:18789404]
synonym: "oxanine-DNA glycosylase activity" RELATED []
is_a: GO:0097506 ! deaminated base DNA N-glycosylase activity
created_by: paola
creation_date: 2013-09-26T16:03:58Z

[Term]
id: GO:0097510
name: base-excision repair, AP site formation via deaminated base removal
namespace: biological_process
def: "A base-excision repair, AP site formation process occurring via excision of a deaminated base." [GOC:al, PMID:18789404]
is_a: GO:0006285 ! base-excision repair, AP site formation
relationship: has_part GO:0097506 ! deaminated base DNA N-glycosylase activity
created_by: paola
creation_date: 2013-10-08T14:44:01Z

[Term]
id: GO:0097511
name: dendritic cell dendrite
namespace: cellular_component
def: "A branched cellular projection (or cytoplasmic extension) that is extended from the surface of a dendritic immune cell, and which enables the cell to sample luminal pathogens and increase the surface area for antigen presentation to T cells." [CL:0000451, GOC:BHF, GOC:cjm, PMID:12200351]
is_a: GO:0042995 ! cell projection
created_by: paola
creation_date: 2013-10-16T13:02:25Z

[Term]
id: GO:0097512
name: cardiac myofibril
namespace: cellular_component
def: "A cardiac myofibril is a myofibril specific to cardiac muscle cells." [GOC:cjm, GOC:devbiol]
is_a: GO:0030016 ! myofibril
created_by: paola
creation_date: 2013-10-16T13:04:58Z

[Term]
id: GO:0097513
name: myosin II filament
namespace: cellular_component
def: "A bipolar filament composed of myosin II molecules." [GOC:cjm, GOC:mah]
is_a: GO:0032982 ! myosin filament
created_by: paola
creation_date: 2013-10-16T13:06:20Z

[Term]
id: GO:0097514
name: sexual spore wall
namespace: cellular_component
def: "A specialized envelope lying outside the cell membrane of a spore derived from a product of meiosis." [GOC:cjm, GOC:mah]
is_a: GO:0031160 ! spore wall
created_by: paola
creation_date: 2013-10-16T15:10:32Z

[Term]
id: GO:0097515
name: asexual spore wall
namespace: cellular_component
def: "A specialized envelope lying outside the cell membrane of a spore derived from an asexual process. Examples of this process are found in bacterial and fungal species." [GOC:cjm, GOC:mah]
is_a: GO:0031160 ! spore wall
created_by: paola
creation_date: 2013-10-16T15:11:21Z

[Term]
id: GO:0097516
name: microvillar actin bundle
namespace: cellular_component
def: "A parallel bundle of actin filaments at the core of a microvillus." [GOC:cjm, GOC:mah]
is_a: GO:0098859 ! actin filament bundle of actin-based cell projection
intersection_of: GO:0097518 ! parallel actin filament bundle
intersection_of: part_of GO:0005902 ! microvillus
relationship: part_of GO:0005902 ! microvillus
created_by: paola
creation_date: 2013-10-16T15:12:13Z

[Term]
id: GO:0097517
name: contractile actin filament bundle
namespace: cellular_component
def: "An actin filament bundle in which the filaments are loosely packed (approximately 30-60 nm apart) and arranged with opposing polarities; the loose packing allows myosin (usually myosin-II) to enter the bundle." [GOC:cjm, GOC:mah, ISBN:0815316194]
is_a: GO:0032432 ! actin filament bundle
disjoint_from: GO:0097518 ! parallel actin filament bundle
created_by: paola
creation_date: 2013-10-16T15:41:14Z

[Term]
id: GO:0097518
name: parallel actin filament bundle
namespace: cellular_component
def: "An actin filament bundle in which the filaments are tightly packed (approximately 10-20 nm apart) and oriented with the same polarity." [GOC:cjm, GOC:mah, ISBN:0815316194]
is_a: GO:0032432 ! actin filament bundle
created_by: paola
creation_date: 2013-10-16T15:42:17Z

[Term]
id: GO:0097519
name: DNA recombinase complex
namespace: cellular_component
def: "A protein-DNA complex consisting of a higher-order oligomer of strand exchange proteins (recombinases) on single-stranded DNA." [GOC:cjm, PMID:10357855]
is_a: GO:0032993 ! protein-DNA complex
created_by: paola
creation_date: 2013-10-16T15:43:22Z

[Term]
id: GO:0097520
name: nucleotide-excision repair, preincision complex
namespace: cellular_component
def: "A multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage." [GOC:cjm, GOC:elh, PMID:10197977]
synonym: "UvrA(2)-UvrB(2) complex" NARROW [PMID:12145219]
synonym: "UvrA(2)B(2) complex" NARROW [GOC:bm, PMID:12145219]
synonym: "UvrB dimer" NARROW [GOC:bm, PMID:12145219]
is_a: GO:0032993 ! protein-DNA complex
created_by: paola
creation_date: 2013-10-17T14:32:37Z

[Term]
id: GO:0097522
name: protein-DNA ISRE complex
namespace: cellular_component
def: "A protein-DNA complex formed through interaction of the protein(s) with an interferon-stimulated response element (ISRE) in the DNA." [GOC:amm, GOC:cjm, PMID:11747630]
is_a: GO:0032993 ! protein-DNA complex
created_by: paola
creation_date: 2013-10-17T14:35:07Z

[Term]
id: GO:0097523
name: transcription ternary complex
namespace: cellular_component
def: "A protein-DNA-RNA complex composed of RNA polymerase, template DNA, and an RNA transcript." [GOC:cjm, GOC:txnOH]
synonym: "transcription protein-DNA-RNA complex" EXACT []
is_a: GO:0001114 ! protein-DNA-RNA complex
created_by: paola
creation_date: 2013-10-18T11:29:57Z

[Term]
id: GO:0097524
name: sperm plasma membrane
namespace: cellular_component
def: "A plasma membrane that is part of a sperm cell." [GOC:cjm]
is_a: GO:0005886 ! plasma membrane
is_a: GO:0097223 ! sperm part
created_by: paola
creation_date: 2013-10-18T11:31:17Z

[Term]
id: GO:0097525
name: spliceosomal snRNP complex
namespace: cellular_component
def: "A ribonucleoprotein complex involved in formation of the spliceosome and composed of one or more snRNA and multiple protein components." [GOC:pr, ISBN:0879695897]
is_a: GO:0030532 ! small nuclear ribonucleoprotein complex
created_by: paola
creation_date: 2013-10-18T15:57:45Z

[Term]
id: GO:0097526
name: spliceosomal tri-snRNP complex
namespace: cellular_component
def: "A spliceosomal snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins." [GOC:pr, ISBN:0879695897, PMID:9452384]
is_a: GO:0097525 ! spliceosomal snRNP complex
created_by: paola
creation_date: 2013-10-18T15:58:47Z

[Term]
id: GO:0097527
name: necroptotic signaling pathway
namespace: biological_process
def: "A series of molecular signals which triggers the necroptotic death of a cell. The pathway starts with reception of a signal, is characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3), and ends when the execution phase of necroptosis is triggered." [GOC:mtg_apoptosis, PMID:20823910]
comment: Gene products that may be annotated to this term include: 1) ligands such as TNF-alpha; 2) receptors such as TNFR (though care should be taken because TNF-alpha and TNFR may also be involved in non-necroptotic processes); 3) signaling molecules such as TNFR-associated death domain (TRADD), receptor-interacting protein kinase 1 (RIP1), cellular inhibitor of apoptosis 1 (cIAP1), cIAP2, TNFR-associated factor 2 (TRAF2) and TRAF5. Within the so-called complex I, RIP1 is polyubiquitinated by cIAPs, thereby providing a docking site for the recruitment of transforming growth factor beta (TGFbeta)-activated kinase 1 (TAK1), TAK1-binding protein 2 (TAB2) and TAB3 (which together deliver a pro-survival signal by activating the transcription factor NF-kB). In some pathophysiological and experimental settings, and in particular when caspase-8 is absent or when caspases are inhibited by pharmacological agents, cylindromatosis (CYLD)-deubiquitinated RIP1 engage in physical and functional interactions with its homolog RIP3, ultimately activating the execution of necrotic cell death. (The pathway downstream of RIPK3 remains largely unknown, although ROS generation, calcium overload, and the opening of the mitochondrial permeability transition pore have been implicated (PMID:22265414)). A necroptotic signaling pathway may also be induced by alkylating DNA damage (possibly by the overactivation of poly(ADP-ribose) polymerase 1, PARP1). This is sometimes referred to as PARP-dependent cell death or parthanatos; it is still being debated if it constitutes an independent cell death modality.
synonym: "necroptosis signaling" RELATED []
synonym: "necroptosis signaling pathway" EXACT []
synonym: "necroptotic signal transduction" EXACT [GOC:signaling]
synonym: "necroptotic signalling pathway" RELATED []
is_a: GO:0007165 ! signal transduction
relationship: part_of GO:0070266 ! necroptotic process
created_by: paola
creation_date: 2013-11-05T14:17:28Z

[Term]
id: GO:0097528
name: execution phase of necroptosis
namespace: biological_process
def: "A stage of the necroptotic process that starts after a necroptotic signal has been relayed to the execution machinery. Key steps of the execution phase are swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. The execution phase ends when the cell has died." [GOC:mtg_apoptosis, PMID:20823910]
synonym: "execution phase of necroptotic process" EXACT []
synonym: "necroptosis" BROAD []
synonym: "necroptotic execution phase" EXACT []
is_a: GO:0044763 ! single-organism cellular process
relationship: part_of GO:0070266 ! necroptotic process
created_by: paola
creation_date: 2013-11-05T14:23:53Z

[Term]
id: GO:0097529
name: myeloid leukocyte migration
namespace: biological_process
def: "The movement of a myeloid leukocyte within or between different tissues and organs of the body." [GOC:cvs, PMID:22342843, PMID:24157461]
is_a: GO:0050900 ! leukocyte migration
created_by: paola
creation_date: 2013-11-11T13:59:43Z

[Term]
id: GO:0097530
name: granulocyte migration
namespace: biological_process
def: "The movement of a granulocyte within or between different tissues and organs of the body." [GOC:cvs, PMID:24163421, PMID:24193336]
is_a: GO:0097529 ! myeloid leukocyte migration
created_by: paola
creation_date: 2013-11-11T14:00:44Z

[Term]
id: GO:0097531
name: mast cell migration
namespace: biological_process
def: "The movement of a mast cell within or between different tissues and organs of the body." [GOC:cvs, PMID:24152847]
is_a: GO:0097529 ! myeloid leukocyte migration
created_by: paola
creation_date: 2013-11-11T14:01:41Z

[Term]
id: GO:0097532
name: stress response to acid chemical
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form." [GOC:aa, GOC:BHF, GOC:go_curators, GOC:rl, http://en.wikipedia.org/wiki/Acid, PMID:10615049, PMID:19170886]
synonym: "response to acid stress" BROAD []
synonym: "stress response to acid" BROAD []
is_a: GO:0001101 ! response to acid chemical
is_a: GO:0006950 ! response to stress
created_by: paola
creation_date: 2013-11-12T13:04:15Z

[Term]
id: GO:0097533
name: cellular stress response to acid chemical
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in cellular homeostasis caused by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form." [GOC:aa, GOC:BHF, GOC:go_curators, GOC:rl, http://en.wikipedia.org/wiki/Acid, PMID:10615049, PMID:19170886]
synonym: "cellular response to acid stress" BROAD []
synonym: "cellular stress response to acid" BROAD []
is_a: GO:0097532 ! stress response to acid chemical
relationship: part_of GO:0033554 ! cellular response to stress
relationship: part_of GO:0071229 ! cellular response to acid chemical
created_by: paola
creation_date: 2013-11-12T13:07:12Z

[Term]
id: GO:0097534
name: lymphoid lineage cell migration
namespace: biological_process
def: "The orderly movement of a lymphoid lineage cell from one site to another. A lymphoid lineage cell, also called a lymphoid lineage restricted progenitor cell, is a progenitor cell restricted to the lymphoid lineage." [GOC:pr, PMID:22342843]
synonym: "lymphoid lineage restricted progenitor cell migration" EXACT []
is_a: GO:0016477 ! cell migration
created_by: paola
creation_date: 2013-11-28T10:47:15Z

[Term]
id: GO:0097535
name: lymphoid lineage cell migration into thymus
namespace: biological_process
def: "The movement of a lymphoid lineage cell (also called a lymphoid lineage restricted progenitor cell) into the thymus. Lymphoid lineage cells enter and exit the thymus several times as part of this process." [GOC:cvs, PMID:22342843]
synonym: "lymphoid lineage restricted progenitor cell migration into thymus" EXACT []
is_a: GO:0097534 ! lymphoid lineage cell migration
created_by: paola
creation_date: 2013-11-28T10:48:58Z

[Term]
id: GO:0097536
name: thymus epithelium morphogenesis
namespace: biological_process
def: "The process in which the thymus epithelium is generated and organized." [GOC:pr, PMID:22342843]
synonym: "thymic epithelium morphogenesis" EXACT []
is_a: GO:0002009 ! morphogenesis of an epithelium
relationship: part_of GO:0048538 ! thymus development
created_by: paola
creation_date: 2013-11-28T10:51:03Z

[Term]
id: GO:0097537
name: Y-shaped link
namespace: cellular_component
def: "A Y-shaped protein complex in the ciliary transition zone that connects the cilium axoneme to the ciliary necklace. Both protein sorting and protein gating occur at this point in the cilium allowing some, but not all proteins to enter the cilium." [GOC:cilia, PMID:22653444, PMID:4554367]
synonym: "membrane-microtubule complex" RELATED []
synonym: "Y-link" RELATED []
synonym: "Y-link structure" RELATED []
synonym: "Y-shaped assemblage" RELATED []
synonym: "Y-shaped fiber" RELATED []
synonym: "Y-shaped fibre" RELATED []
synonym: "Y-shaped linker" RELATED []
is_a: GO:0043234 ! protein complex
is_a: GO:0044441 ! ciliary part
relationship: part_of GO:0035869 ! ciliary transition zone
created_by: paola
creation_date: 2013-12-03T16:34:34Z

[Term]
id: GO:0097538
name: ciliary necklace
namespace: cellular_component
def: "A protein complex located on the cilium membrane in the ciliary transition zone; it is connected to the cilium axoneme via Y-shaped links." [GOC:cilia, PMID:22653444, PMID:4554367]
synonym: "cilial necklace" EXACT []
synonym: "cilium necklace" EXACT []
is_a: GO:0044441 ! ciliary part
is_a: GO:0098797 ! plasma membrane protein complex
relationship: part_of GO:0035869 ! ciliary transition zone
relationship: part_of GO:0060170 ! ciliary membrane
created_by: paola
creation_date: 2013-12-03T16:43:41Z

[Term]
id: GO:0097539
name: ciliary transition fiber
namespace: cellular_component
def: "A nine-bladed, propeller-like protein complex that links the distal end of the basal body and the cilium to the plasma membrane. Functions in protein sorting and gating (i.e. active and passive transport of proteins in and out of the cilium)." [GOC:cilia, GOC:kmv, GOC:krc, PMID:22653444, PMID:24231678, PMID:5064817, PMID:5335827]
comment: In mammals, ciliary transition fibers comprise at least five components (Ccdc41/Cep83, Cep89/Cep123, Sclt1, Fbf1, and Cep164) (PMID:24469809).
synonym: "centriolar distal appendage" RELATED [PMID:24469809]
synonym: "cilial transition fiber" EXACT []
synonym: "cilial transition fibre" EXACT []
synonym: "ciliary transition fibre" EXACT []
synonym: "cilium transition fiber" EXACT []
synonym: "cilium transition fibre" EXACT []
synonym: "distal appendage of basal body" RELATED [GOC:krc]
synonym: "distal appendage of centriole" RELATED [GOC:krc]
synonym: "distal appendage of mother centriole" RELATED [GOC:krc]
synonym: "transition fiber" BROAD []
synonym: "transition fibre" BROAD []
is_a: GO:0043234 ! protein complex
is_a: GO:0044441 ! ciliary part
created_by: paola
creation_date: 2013-12-03T16:46:37Z

[Term]
id: GO:0097540
name: axonemal central pair
namespace: cellular_component
def: "Part of the axoneme consisting of the inner two microtubule doublets of the 9+2 axoneme occurring in most motile cilia." [GOC:cilia, PMID:24283352]
synonym: "axonemal microtubule central pair" EXACT []
synonym: "axoneme central pair" EXACT []
synonym: "axoneme microtubule central pair" EXACT []
synonym: "central pair" BROAD []
synonym: "central-pair microtubules" RELATED []
is_a: GO:0044447 ! axoneme part
relationship: has_part GO:0005879 ! axonemal microtubule
created_by: paola
creation_date: 2013-12-12T11:07:09Z

[Term]
id: GO:0097541
name: axonemal basal plate
namespace: cellular_component
def: "Part of the axoneme consisting of a highly electron-dense region at the distal end of the ciliary transition zone within the axonemal lumen at which the axonemal central pair of microtubules is connected to the rest of the axonemal structure." [GOC:cilia, PMID:23352055, PMID:4554367]
synonym: "axoneme basal plate" EXACT []
synonym: "basal plate" BROAD []
is_a: GO:0044447 ! axoneme part
created_by: paola
creation_date: 2013-12-12T11:10:39Z

[Term]
id: GO:0097542
name: ciliary tip
namespace: cellular_component
def: "Part of the cilium where the axoneme ends. The ciliary tip has been implicated in ciliary assembly and disassembly, as well as signal transduction." [GOC:cilia, PMID:23970417]
comment: Note that cilia and eukaryotic flagella are deemed to be equivalent.
synonym: "cilial tip" EXACT []
synonym: "cilium tip" EXACT []
synonym: "flagellar tip" EXACT []
synonym: "flagellum tip" EXACT []
is_a: GO:0044441 ! ciliary part
created_by: paola
creation_date: 2013-12-12T11:12:22Z

[Term]
id: GO:0097543
name: ciliary inversin compartment
namespace: cellular_component
def: "Proximal part of the ciliary shaft to which the inversin protein (also called Inv) specifically localizes. The inversin compartment appears to have a different protein composition than the rest of the cilium, although there is no structure that separates it form the distal part of the cilium." [GOC:cilia, PMID:19050042]
comment: Note that cilia and eukaryotic flagella are deemed to be equivalent.
synonym: "cilial inversin compartment" EXACT []
synonym: "cilium inversin compartment" EXACT []
synonym: "flagellar inversin compartment" EXACT []
synonym: "flagellum inversin compartment" EXACT []
synonym: "Inv compartment of the cilium" EXACT []
synonym: "inversin compartment" BROAD []
is_a: GO:0044441 ! ciliary part
created_by: paola
creation_date: 2013-12-12T11:14:36Z

[Term]
id: GO:0097544
name: ciliary shaft
namespace: cellular_component
def: "The mid part of a cilium between the ciliary base and ciliary tip that extends into the extracellular space." [GOC:cilia, PMID:19866682]
comment: Note that 'ciliary shaft' is sparingly used in the literature to denote the projecting part of the cilium; many authors would refer to the axoneme instead. However, the definition of GO:0005930 'axoneme' is rather stringent, and the localization of many ciliary proteins would not fit that definition. Also, note that cilia and eukaryotic flagella are deemed to be equivalent.
synonym: "cilial shaft" EXACT []
synonym: "cilium shaft" EXACT []
synonym: "flagellar shaft" EXACT []
synonym: "flagellum shaft" EXACT []
is_a: GO:0044441 ! ciliary part
created_by: paola
creation_date: 2013-12-12T11:17:30Z

[Term]
id: GO:0097545
name: axonemal outer doublet
namespace: cellular_component
def: "Part of an axoneme consisting in a doublet microtubule. Nine of these outer doublets form the 9+0 axoneme, while the 9+2 axoneme also contains a central pair. Dynein arms attached to the doublets provide the mechanism of movement of the cilium." [GOC:cilia, GOC:pr, http://en.wikipedia.org/wiki/Axoneme, PMID:5044758, PMID:5664206]
synonym: "axoneme outer doublet" EXACT []
synonym: "outer doublet" BROAD []
synonym: "outer-doublet microtubules" RELATED []
is_a: GO:0044447 ! axoneme part
relationship: has_part GO:0005874 ! microtubule
relationship: has_part GO:0005879 ! axonemal microtubule
created_by: paola
creation_date: 2013-12-12T11:19:29Z

[Term]
id: GO:0097546
name: ciliary base
namespace: cellular_component
def: "Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area." [GOC:cilia, PMID:22653444]
comment: Due to resolution issues, researchers are often unable to assign protein localization to more specific ciliary compartments such as the basal body, transition fibers or transition zone, and instead refer to 'ciliary base'. The terms GO:0036064 'ciliary basal body', GO:0097539 'ciliary transition fiber' and GO:0035869 'ciliary transition zone' represent strictly defined compartments at the ciliary base and should be used for annotation whenever possible. Also, note that cilia and eukaryotic flagella are deemed to be equivalent.
synonym: "cilial base" EXACT []
synonym: "cilium base" EXACT []
synonym: "flagellar base" EXACT []
synonym: "flagellum base" EXACT []
is_a: GO:0044441 ! ciliary part
created_by: paola
creation_date: 2013-12-17T14:16:04Z

[Term]
id: GO:0097547
name: synaptic vesicle protein transport vesicle
namespace: cellular_component
def: "A cytoplasmic vesicle composed of both tubulovesicular and clear core vesicles that transport synaptic vesicle-associated proteins. Proteins carried by synaptic vesicle protein transport vesicles (STVs) include synaptophysin, synapsin Ia, synaptotagmin and synaptobrevin/vesicle-associated membrane protein 2 (VAMP2). STVs are packaged via the trans-Golgi network before being transported through the axon." [GOC:dr, PMID:21569270]
comment: This term should not be confused with GO:0008021 'synaptic vesicle'. STVs and synaptic vesicles differ both functionally and morphologically. Functionally, STVs are transport vesicles that deliver synaptic vesicle proteins to synapses, while synaptic vesicles are responsible for transmitter release at synapses. Morphologically, synaptic vesicles are very homogeneous, while STVs are very heterogeneous in size and shape. STVs might be a precursor for synaptic vesicles.
synonym: "STV" EXACT []
is_a: GO:0031410 ! cytoplasmic vesicle
created_by: paola
creation_date: 2013-12-20T09:22:03Z

[Term]
id: GO:0097548
name: seed abscission
namespace: biological_process
def: "The controlled shedding of a seed." [GOC:lmo]
is_a: GO:0009838 ! abscission
created_by: paola
creation_date: 2014-01-22T07:57:41Z

[Term]
id: GO:0097549
name: chromatin organization involved in negative regulation of transcription
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription by chromatin organization." [GOC:di, PMID:23123093]
subset: gocheck_do_not_manually_annotate
synonym: "negative regulation of transcription by chromatin organization" EXACT []
is_a: GO:0034401 ! chromatin organization involved in regulation of transcription
intersection_of: GO:0006325 ! chromatin organization
intersection_of: part_of GO:0045892 ! negative regulation of transcription, DNA-templated
relationship: part_of GO:0045892 ! negative regulation of transcription, DNA-templated
created_by: paola
creation_date: 2014-01-22T08:20:50Z

[Term]
id: GO:0097550
name: transcriptional preinitiation complex
namespace: cellular_component
def: "A protein-DNA complex composed of proteins binding promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription." [GOC:di, PMID:22751016]
synonym: "DNA-templated transcriptional preinitiation complex" EXACT []
synonym: "PIC" NARROW []
synonym: "preinitiation complex" NARROW []
synonym: "transcription preinitiation complex" EXACT []
synonym: "transcriptional pre-initiation complex" EXACT []
is_a: GO:0032993 ! protein-DNA complex
created_by: paola
creation_date: 2014-01-22T09:33:44Z

[Term]
id: GO:0097551
name: mitochondrial double-strand break repair
namespace: biological_process
def: "The repair of double-strand breaks in mitochondrial DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:di, PMID:22214610]
comment: Note that the processes of nuclear double-strand break repair and mitochondrial double-strand break repair are genetically separable.
synonym: "mtDSB repair" EXACT []
is_a: GO:0006302 ! double-strand break repair
created_by: paola
creation_date: 2014-01-22T10:06:54Z

[Term]
id: GO:0097552
name: mitochondrial double-strand break repair via homologous recombination
namespace: biological_process
def: "The repair of a double-strand break in mitochondrial DNA in which the broken DNA molecule is repaired using homologous sequences." [GOC:di, PMID:22214610]
comment: Note that the processes of nuclear double-strand break repair and mitochondrial double-strand break repair are genetically separable.
synonym: "mtDSB repair via homologous recombination" EXACT []
is_a: GO:0000725 ! recombinational repair
is_a: GO:0097551 ! mitochondrial double-strand break repair
created_by: paola
creation_date: 2014-01-22T10:09:10Z

[Term]
id: GO:0097553
name: calcium ion transmembrane import into cytosol
namespace: biological_process
def: "A process in which a calcium ion is transported from one side of a membrane to the other into the cytosol by means of some agent such as a transporter or pore." [GOC:vw]
synonym: "calcium transmembrane import into cytosol" BROAD []
is_a: GO:0070588 ! calcium ion transmembrane transport
is_a: GO:1902656 ! calcium ion import into cytosol
created_by: paola
creation_date: 2014-01-23T11:05:13Z

[Term]
id: GO:0097554
name: left anterior flagellum
namespace: cellular_component
def: "A cilium (also called flagellum) found in Giardia species (trophozoite stage). It originates at the left anterior basal body, extends laterally through the cytoplasm, crosses the right anterior axoneme, and exits as a membrane-bound flagellum on the anterior left side of the cell." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
synonym: "left anterior cilium" EXACT []
is_a: GO:0005929 ! cilium
created_by: paola
creation_date: 2014-02-05T12:47:41Z

[Term]
id: GO:0097555
name: right anterior flagellum
namespace: cellular_component
def: "A cilium (also called flagellum) found in Giardia species (trophozoite stage). It originates at the right anterior basal body, extends laterally through the cytoplasm, crosses the left anterior axoneme, and exits as a membrane-bound flagellum on the anterior right side of the cell." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
synonym: "right anterior cilium" EXACT []
is_a: GO:0005929 ! cilium
created_by: paola
creation_date: 2014-02-05T13:18:36Z

[Term]
id: GO:0097556
name: left posteriolateral flagellum
namespace: cellular_component
def: "A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the left posteriolateral basal body and extends cytoplasmically toward the cell posterior, marking the left anterior boundary of the lateral shield and the left lateral region of the funis before exiting at the left lateral region of the cell body." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
synonym: "left posteriolateral cilium" EXACT []
synonym: "left posterolateral cilium" EXACT []
synonym: "left posterolateral flagellum" EXACT []
is_a: GO:0005929 ! cilium
created_by: paola
creation_date: 2014-02-05T13:21:09Z

[Term]
id: GO:0097557
name: right posteriolateral flagellum
namespace: cellular_component
def: "A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the right posteriolateral basal body and extends cytoplasmically toward the cell posterior, marking the right anterior boundary of the lateral shield and the right lateral region of the funis before exiting at the right lateral region of the cell body." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
synonym: "right posteriolateral cilium" EXACT []
synonym: "right posterolateral cilium" EXACT []
synonym: "right posterolateral flagellum" EXACT []
is_a: GO:0005929 ! cilium
created_by: paola
creation_date: 2014-02-05T13:24:55Z

[Term]
id: GO:0097558
name: left ventral flagellum
namespace: cellular_component
def: "A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the left ventral basal body and exits the cell body proximally and dorsal to the ventral disc." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
synonym: "left ventral cilium" EXACT []
is_a: GO:0005929 ! cilium
created_by: paola
creation_date: 2014-02-05T13:26:51Z

[Term]
id: GO:0097559
name: right ventral flagellum
namespace: cellular_component
def: "A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the right ventral basal body and exits the cell body proximally and dorsal to the ventral disc." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
synonym: "right ventral cilium" EXACT []
is_a: GO:0005929 ! cilium
created_by: paola
creation_date: 2014-02-05T13:28:20Z

[Term]
id: GO:0097560
name: left caudal flagellum
namespace: cellular_component
def: "A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the left caudal basal body, extending cytoplasmically and exiting at the posterior end of the cell body." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
synonym: "left caudal cilium" EXACT []
is_a: GO:0005929 ! cilium
created_by: paola
creation_date: 2014-02-05T13:29:44Z

[Term]
id: GO:0097561
name: right caudal flagellum
namespace: cellular_component
def: "A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the right caudal basal body, extending cytoplasmically and exiting at the posterior end of the cell body." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
synonym: "right caudal cilium" EXACT []
is_a: GO:0005929 ! cilium
created_by: paola
creation_date: 2014-02-05T13:31:15Z

[Term]
id: GO:0097562
name: left lateral basal body pair
namespace: cellular_component
def: "Set of two basal bodies found in Giardia species (trophozoite stage). It comprises the anterior and ventral basal bodies located to the right of the left nucleus of the trophozoite when viewed dorsally." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344]
comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
is_a: GO:0044463 ! cell projection part
relationship: has_part GO:1902671 ! left anterior basal body
relationship: has_part GO:1902675 ! left ventral basal body
created_by: paola
creation_date: 2014-02-05T16:09:11Z

[Term]
id: GO:0097563
name: left middle basal body pair
namespace: cellular_component
def: "Set of two basal bodies found in Giardia species (trophozoite stage). It comprises the caudal and posteriolateral basal bodies located to the right of the left nucleus of the trophozoite when viewed dorsally." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344]
comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
is_a: GO:0044463 ! cell projection part
relationship: has_part GO:1902673 ! left posteriolateral basal body
relationship: has_part GO:1902677 ! left caudal basal body
created_by: paola
creation_date: 2014-02-05T16:11:14Z

[Term]
id: GO:0097564
name: right lateral basal body pair
namespace: cellular_component
def: "Set of two basal bodies found in Giardia species (trophozoite stage). It comprises the anterior and ventral basal bodies located to the left of the right nucleus of the trophozoite when viewed dorsally." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344]
comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
is_a: GO:0044463 ! cell projection part
relationship: has_part GO:1902672 ! right anterior basal body
relationship: has_part GO:1902676 ! right ventral basal body
created_by: paola
creation_date: 2014-02-05T16:12:42Z

[Term]
id: GO:0097565
name: right middle basal body pair
namespace: cellular_component
def: "Set of two basal bodies found in Giardia species (trophozoite stage). It comprises the caudal and posteriolateral basal bodies located to the left of the right nucleus of the trophozoite when viewed dorsally." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344]
comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
is_a: GO:0044463 ! cell projection part
relationship: has_part GO:1902674 ! right posteriolateral basal body
relationship: has_part GO:1902678 ! right caudal basal body
created_by: paola
creation_date: 2014-02-05T16:14:05Z

[Term]
id: GO:0097566
name: left tetrad
namespace: cellular_component
def: "Set of four basal bodies found in Giardia species (trophozoite stage). It comprises the left lateral basal body pair and the left middle basal body pair (i.e. the anterior, ventral, caudal and posteriolateral basal bodies located to the right of the left nucleus of the trophozoite when viewed dorsally)." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344]
comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
is_a: GO:0044463 ! cell projection part
relationship: has_part GO:0097562 ! left lateral basal body pair
relationship: has_part GO:0097563 ! left middle basal body pair
created_by: paola
creation_date: 2014-02-05T16:30:43Z

[Term]
id: GO:0097567
name: right tetrad
namespace: cellular_component
def: "Set of four basal bodies found in Giardia species (trophozoite stage). It comprises the right lateral basal body pair and the right middle basal body pair (i.e. the anterior, ventral, caudal and posteriolateral basal bodies located to the left of the right nucleus of the trophozoite when viewed dorsally)." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344]
comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
is_a: GO:0044463 ! cell projection part
relationship: has_part GO:0097564 ! right lateral basal body pair
relationship: has_part GO:0097565 ! right middle basal body pair
created_by: paola
creation_date: 2014-02-05T16:32:33Z

[Term]
id: GO:0097568
name: median body
namespace: cellular_component
def: "A non-membrane bound, semi-organized microtubule array of unknown function found in Giardia species (trophozoite stage). It is located on the dorsal side of the trophozoite, slightly posterior to the ventral disc." [GOC:giardia, PMID:5961344]
comment: Note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
synonym: "parabasal body" RELATED []
is_a: GO:0044430 ! cytoskeletal part
relationship: has_part GO:0005874 ! microtubule
created_by: paola
creation_date: 2014-02-11T13:34:19Z

[Term]
id: GO:0097569
name: lateral shield
namespace: cellular_component
def: "Region of the ventral side of the cell body found in Giardia species (trophozoite stage). It is located posterior on either side of the ventral groove; the upper boundary is the ventral disc, and the lower boundary is marked by the posteriolateral flagella." [GOC:giardia, ISBN:9780124260207]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
is_a: GO:0044464 ! cell part
relationship: part_of GO:0044297 ! cell body
created_by: paola
creation_date: 2014-02-11T13:37:10Z

[Term]
id: GO:0097570
name: cyst wall
namespace: cellular_component
def: "The specialized envelope lying outside the cell membrane of a cyst. A cyst is a resting or dormant stage of a microorganism, usually a bacterium or a protist or rarely an invertebrate animal, that helps the organism to survive in unfavorable environmental conditions. In protists such as protozoan parasites alternating cystic- and non-cystic stages, the cyst wall is usually composed of carbohydrates and proteins." [GOC:giardia, http://en.wikipedia.org/wiki/Microbial_cyst, PMID:15134259, PMID:2026212]
is_a: GO:0005618 ! cell wall
created_by: paola
creation_date: 2014-02-18T10:25:53Z

[Term]
id: GO:0097571
name: left nucleus
namespace: cellular_component
def: "One of the two nuclei found in Giardia species (trophozoite stage). It is located on the left side of the cell when viewed from the dorsal side." [GOC:giardia, ISBN:0-444-81258-X]
comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
is_a: GO:0005634 ! nucleus
created_by: paola
creation_date: 2014-02-18T11:21:31Z

[Term]
id: GO:0097572
name: right nucleus
namespace: cellular_component
def: "One of the two nuclei found in Giardia species (trophozoite stage). It is located on the right side of the cell when viewed from the dorsal side." [GOC:giardia, ISBN:0-444-81258-X]
comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
is_a: GO:0005634 ! nucleus
created_by: paola
creation_date: 2014-02-18T11:23:01Z

[Term]
id: GO:0097573
name: glutathione oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein-S-S-glutathione + glutathione-SH = protein-SH + glutathione-S-S-glutathione." [GOC:jd, PMID:18992757]
comment: Note that this activity is different from GO:0015038 'glutathione disulfide oxidoreductase activity'. See PMID:18992757: "Grxs [glutaredoxins] can also reduce mixed disulfides between proteins or low molecular weight thiols and GSH in reactions that require only their N-terminal active- site cysteine. It is important to note that the reduction of glutathionylated substrates through the monothiol mechanism seems to be the major activity of Grxs; all dithiol Grxs described so far catalyze these reactions, but not all dithiol Grxs catalyze the reduction of protein disulfides by the dithiol mechanism".
is_a: GO:0015035 ! protein disulfide oxidoreductase activity
created_by: paola
creation_date: 2014-02-19T13:41:38Z

[Term]
id: GO:0097574
name: lateral part of cell
namespace: cellular_component
def: "The region of a polarized cell other than its tips or ends (in some cell types, one end may be called the apex and the other the base). For example, in a polarized epithelial cell, the lateral part includes the cell sides which interface adjacent cells." [GOC:pr]
is_a: GO:0044464 ! cell part
created_by: paola
creation_date: 2014-02-26T13:27:27Z

[Term]
id: GO:0097575
name: lateral cell cortex
namespace: cellular_component
def: "The region directly beneath the plasma membrane of the lateral portion of the cell." [GOC:mah, PMID:24146635]
is_a: GO:0099738 ! cell cortex region
intersection_of: GO:0099738 ! cell cortex region
intersection_of: part_of GO:0097574 ! lateral part of cell
relationship: part_of GO:0097574 ! lateral part of cell
created_by: paola
creation_date: 2014-02-26T13:29:22Z

[Term]
id: GO:0097576
name: vacuole fusion
namespace: biological_process
def: "Merging of two or more vacuoles, or of vacuoles and vesicles within a cell to form a single larger vacuole." [GOC:pr, GOC:vw, http://en.wikipedia.org/wiki/Vacuole]
is_a: GO:0007033 ! vacuole organization
is_a: GO:0048284 ! organelle fusion
created_by: paola
creation_date: 2014-02-28T09:49:31Z

[Term]
id: GO:0097577
name: sequestering of iron ion
namespace: biological_process
def: "The process of binding or confining iron ions such that they are separated from other components of a biological system." [GOC:mr, PMID:3099306]
synonym: "iron ion retention" EXACT []
synonym: "iron ion sequestering" EXACT []
synonym: "iron ion sequestration" EXACT []
synonym: "iron ion storage" EXACT []
synonym: "retention of iron ion" EXACT []
synonym: "sequestration of iron ion" EXACT []
synonym: "storage of iron ion" EXACT []
is_a: GO:0051238 ! sequestering of metal ion
relationship: part_of GO:0006879 ! cellular iron ion homeostasis
created_by: paola
creation_date: 2014-02-28T11:10:53Z

[Term]
id: GO:0097578
name: sequestering of copper ion
namespace: biological_process
def: "The process of binding or confining copper ions such that they are separated from other components of a biological system." [GOC:mr, PMID:3099306]
synonym: "copper ion retention" EXACT []
synonym: "copper ion sequestering" EXACT []
synonym: "copper ion sequestration" EXACT []
synonym: "copper ion storage" EXACT []
synonym: "retention of copper ion" EXACT []
synonym: "sequestration of copper ion" EXACT []
synonym: "storage of copper ion" EXACT []
is_a: GO:0006878 ! cellular copper ion homeostasis
is_a: GO:0051238 ! sequestering of metal ion
is_a: GO:1902578 ! single-organism localization
created_by: paola
creation_date: 2014-02-28T11:15:02Z

[Term]
id: GO:0097579
name: extracellular sequestering of copper ion
namespace: biological_process
def: "The process of binding or confining copper ions in an extracellular area such that they are separated from other components of a biological system." [GOC:mr, PMID:3099306]
synonym: "extracellular copper ion retention" EXACT []
synonym: "extracellular copper ion sequestering" EXACT []
synonym: "extracellular copper ion sequestration" EXACT []
synonym: "extracellular copper ion storage" EXACT []
synonym: "extracellular retention of copper ion" EXACT []
synonym: "extracellular sequestration of copper ion" EXACT []
synonym: "extracellular storage of copper ion" EXACT []
is_a: GO:0097578 ! sequestering of copper ion
intersection_of: GO:0097578 ! sequestering of copper ion
intersection_of: occurs_in GO:0005576 ! extracellular region
relationship: occurs_in GO:0005576 ! extracellular region
relationship: part_of GO:0006878 ! cellular copper ion homeostasis
created_by: paola
creation_date: 2014-02-28T11:18:04Z

[Term]
id: GO:0097580
name: intracellular sequestering of copper ion
namespace: biological_process
def: "The process of binding or confining copper ions in an intracellular area such that they are separated from other components of a biological system." [GOC:mr, PMID:3099306]
subset: gosubset_prok
synonym: "intracellular copper ion retention" EXACT []
synonym: "intracellular copper ion sequestering" EXACT []
synonym: "intracellular copper ion sequestration" EXACT []
synonym: "intracellular copper ion storage" EXACT []
synonym: "intracellular retention of copper ion" EXACT []
synonym: "intracellular sequestration of copper ion" EXACT []
synonym: "intracellular storage of copper ion" EXACT []
is_a: GO:0051651 ! maintenance of location in cell
is_a: GO:0097578 ! sequestering of copper ion
intersection_of: GO:0097578 ! sequestering of copper ion
intersection_of: occurs_in GO:0005622 ! intracellular
relationship: occurs_in GO:0005622 ! intracellular
relationship: part_of GO:0006878 ! cellular copper ion homeostasis
created_by: paola
creation_date: 2014-02-28T11:21:39Z

[Term]
id: GO:0097581
name: lamellipodium organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lamellipodium. A lamellipodium is a thin sheetlike process extended by the leading edge of a crawling fibroblast; contains a dense meshwork of actin filaments." [GOC:als, PMID:16054028]
is_a: GO:0030030 ! cell projection organization
created_by: paola
creation_date: 2014-02-28T16:08:56Z

[Term]
id: GO:0097582
name: dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt2p dimer complex
namespace: cellular_component
def: "A protein dimer complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity and, in S. cerevisiae, is composed of Pmt1p-Pmt2p." [GOC:jd, PMID:12551906]
synonym: "Pmt1p-Pmt2p complex" NARROW []
is_a: GO:0031502 ! dolichyl-phosphate-mannose-protein mannosyltransferase complex
created_by: paola
creation_date: 2014-03-02T18:13:34Z

[Term]
id: GO:0097583
name: dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt3p dimer complex
namespace: cellular_component
def: "A protein dimer complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity and, in S. cerevisiae, is composed of Pmt1p-Pmt3p." [GOC:jd, PMID:12551906]
synonym: "Pmt1p-Pmt3p complex" NARROW []
is_a: GO:0031502 ! dolichyl-phosphate-mannose-protein mannosyltransferase complex
created_by: paola
creation_date: 2014-03-02T18:16:29Z

[Term]
id: GO:0097584
name: dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt2p dimer complex
namespace: cellular_component
def: "A protein dimer complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity and, in S. cerevisiae, is composed of Pmt5p-Pmt2p." [GOC:jd, PMID:12551906]
synonym: "Pmt5p-Pmt2p complex" NARROW []
is_a: GO:0031502 ! dolichyl-phosphate-mannose-protein mannosyltransferase complex
created_by: paola
creation_date: 2014-03-02T18:17:22Z

[Term]
id: GO:0097585
name: dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt3p dimer complex
namespace: cellular_component
def: "A protein dimer complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity and, in S. cerevisiae, is composed of Pmt5p-Pmt3p." [GOC:jd, PMID:12551906]
synonym: "Pmt5p-Pmt3p complex" NARROW []
is_a: GO:0031502 ! dolichyl-phosphate-mannose-protein mannosyltransferase complex
created_by: paola
creation_date: 2014-03-02T18:18:28Z

[Term]
id: GO:0097586
name: dolichyl-phosphate-mannose-protein mannosyltransferase Pmt4p homodimer complex
namespace: cellular_component
def: "A protein dimer complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity and, in S. cerevisiae, is composed of Pmt4p." [GOC:bhm, GOC:jd, PMID:12551906]
synonym: "dolichyl-phosphate-mannose-protein mannosyltransferase Pmt4p dimer" EXACT []
synonym: "dolichyl-phosphate-mannose-protein mannosyltransferase Pmt4p-Pmt4p dimer complex" EXACT []
synonym: "Pmt4p-Pmt4p complex" NARROW []
is_a: GO:0031502 ! dolichyl-phosphate-mannose-protein mannosyltransferase complex
created_by: paola
creation_date: 2014-03-02T18:19:05Z

[Term]
id: GO:0097587
name: MutLgamma complex
namespace: cellular_component
def: "A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In S. cerevisiae the complex consists of two subunits, Mlh1 and Mlh3." [GOC:jd, PMID:10570173]
is_a: GO:0032300 ! mismatch repair complex
created_by: paola
creation_date: 2014-03-06T11:48:12Z

[Term]
id: GO:0097588
name: archaeal or bacterial-type flagellum-dependent cell motility
namespace: biological_process
def: "Cell motility due to movement of bacterial- or archaeal-type flagella." [GOC:cilia, GOC:krc]
comment: Bacterial- and archaeal-type flagella are superficially similar but have a different molecular composition and fine structure. This term was added for mapping to the UniProt keyword "flagellar rotation". For manual annotation, please use one of the child terms of GO:0097588 that refer specifically to either archaeal- or bacterial-type flagella.
is_a: GO:0001539 ! cilium or flagellum-dependent cell motility
created_by: paola
creation_date: 2014-03-25T16:51:19Z

[Term]
id: GO:0097589
name: archaeal-type flagellum
namespace: cellular_component
def: "A non-membrane-bounded organelle superficially similar to a bacterial-type flagellum; they both consist of filaments extending outside the cell, and rotate to propel the cell, but the archaeal flagella (also called archaella) have a unique structure which lacks a central channel. Similar to bacterial type IV pilins, the archaeal flagellins (archaellins) are made with class 3 signal peptides and they are processed by a type IV prepilin peptidase-like enzyme. The archaellins are typically modified by the addition of N-linked glycans which are necessary for proper assembly and/or function." [GOC:cilia, GOC:krc, http://en.wikipedia.org/wiki/Flagellum#Archaeal, PMID:21265748, PMID:23146836, PMID:23204365, PMID:24330313]
synonym: "archaeal flagellum" RELATED []
synonym: "archaella" RELATED []
synonym: "archaellum" EXACT []
is_a: GO:0042995 ! cell projection
is_a: GO:0043228 ! non-membrane-bounded organelle
created_by: paola
creation_date: 2014-03-25T20:36:24Z

[Term]
id: GO:0097590
name: archaeal-type flagellum-dependent cell motility
namespace: biological_process
def: "Cell motility due to the motion of one or more archaeal-type flagella. An archaeal-type flagellum (also called archaellum) is a non-membrane-bounded organelle superficially similar to a bacterial-type flagellum, but having a different molecular structure and lacking a central channel." [GOC:cilia, GOC:krc, http://en.wikipedia.org/wiki/Flagellum#Archaeal]
synonym: "archaeal-type flagellar cell motility" RELATED []
is_a: GO:0097588 ! archaeal or bacterial-type flagellum-dependent cell motility
created_by: paola
creation_date: 2014-03-25T20:40:50Z

[Term]
id: GO:0097591
name: ventral disc lateral crest
namespace: cellular_component
def: "Fibrillar repetitive structure surrounding the ventral disc edge in Giardia species (trophozoite stage). The composition of the lateral crest is not fully known yet." [GOC:giardia]
comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
synonym: "lateral crest" BROAD []
synonym: "ventral disk lateral crest" RELATED []
is_a: GO:0044422 ! organelle part
created_by: paola
creation_date: 2014-04-03T10:47:48Z

[Term]
id: GO:0097592
name: ventral disc overlap zone
namespace: cellular_component
def: "A region of the ventral disc of Giardia species (trophozoite stage) where two portions of the same array of microtubules overlap (the microtubule array makes a complete circle and overlaps on itself)." [GOC:giardia]
comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
synonym: "overlap zone" BROAD []
synonym: "ventral disk overlap zone" RELATED []
is_a: GO:0044422 ! organelle part
relationship: has_part GO:0097593 ! ventral disc microtubule array
created_by: paola
creation_date: 2014-04-03T11:12:50Z

[Term]
id: GO:0097593
name: ventral disc microtubule array
namespace: cellular_component
def: "A part of the ventral disc of Giardia species (trophozoite stage) consisting of a spiral array of microtubules linked to the ventral membrane. These microtubules form the base of the ventral disc dorsal microribbons that extend nearly perpendicular from the membrane." [GOC:giardia]
comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
synonym: "spiral microtubule array" BROAD []
synonym: "ventral disc spiral microtubule array" EXACT []
synonym: "ventral disk microtubule array" RELATED []
is_a: GO:0044422 ! organelle part
relationship: has_part GO:0005874 ! microtubule
created_by: paola
creation_date: 2014-04-03T11:17:17Z

[Term]
id: GO:0097594
name: ventral disc dorsal microribbon
namespace: cellular_component
def: "Trilaminar structure extending perpendicularly into the cytoplasm along the length of ventral disc microtubules in Giardia species (trophozoite stage). Constituents of dorsal microribbons (also called dorsal ribbons or microribbons) include alpha-coiled-helix proteins approximately 29 to 38 kDa in size. These proteins line the edges of the microribbons but are not found in microtubules. Tubulins are not found in microribbons." [GOC:giardia, PMID:11432808]
comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
synonym: "dorsal microribbon" BROAD []
synonym: "dorsal ribbon" BROAD []
synonym: "microribbon" BROAD []
synonym: "ventral disk dorsal microribbon" RELATED []
is_a: GO:0044422 ! organelle part
created_by: paola
creation_date: 2014-04-03T11:20:06Z

[Term]
id: GO:0097595
name: ventral disc crossbridge
namespace: cellular_component
def: "Structure horizontally linking adjacent microribbons of the ventral disc in Giardia species (trophozoite stage). The composition of crossbridges is not fully known yet." [GOC:giardia]
comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
synonym: "crossbridge" BROAD []
synonym: "ventral disk crossbridge" RELATED []
is_a: GO:0044422 ! organelle part
created_by: paola
creation_date: 2014-04-03T11:23:33Z

[Term]
id: GO:0097596
name: ventral disc supernumerary microtubule array
namespace: cellular_component
def: "A partial left-handed spiral array of microtubules that lies generally dorsal to the main ventral disc microtubule array in Giardia species (trophozoite stage)." [GOC:giardia, ISBN:9780124260207]
comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
synonym: "supernumerary microtubule array" BROAD []
synonym: "ventral disk supernumerary microtubule array" RELATED []
is_a: GO:0044422 ! organelle part
relationship: has_part GO:0005874 ! microtubule
relationship: part_of GO:0097597 ! ventral disc
created_by: paola
creation_date: 2014-04-03T11:25:07Z

[Term]
id: GO:0097597
name: ventral disc
namespace: cellular_component
def: "Specialized organelle found in Giardia species (trophozoite stage) and characterized by a spiral array of microtubules and microtubule-associated structures including dorsal microribbons and crossbridges. The edge of the ventral disc narrows into a lateral crest. The ventral disk mediates mechanical attachment of the trophozoite to the host's intestinal wall, and contains the contractile proteins actinin, alpha-actinin, myosin, and tropomyosin working towards contraction of the disk involved in adherence." [GOC:giardia, ISBN:9780124260207, PMID:11432808, PMID:4777416, PMID:5961344]
comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
synonym: "adhesive disc" RELATED []
synonym: "ventral adhesive disc" EXACT []
synonym: "ventral disk" RELATED []
is_a: GO:0043226 ! organelle
relationship: has_part GO:0097591 ! ventral disc lateral crest
relationship: has_part GO:0097592 ! ventral disc overlap zone
relationship: has_part GO:0097593 ! ventral disc microtubule array
relationship: has_part GO:0097594 ! ventral disc dorsal microribbon
relationship: has_part GO:0097595 ! ventral disc crossbridge
created_by: paola
creation_date: 2014-04-03T11:29:58Z

[Term]
id: GO:0097598
name: sperm cytoplasmic droplet
namespace: cellular_component
def: "A small amount of cytoplasm surrounded by a cell membrane that is generally retained in spermatozoa after spermiogenesis, when the majority of the cytoplasm is phagocytosed by Sertoli cells to produce \"residual bodies\". Initially, the droplet is located at the neck just behind the head of an elongated spermatid. During epididymal transit, the cytoplasmic droplet migrates caudally to the annulus at the end of the midpiece; the exact position and time varies by species. The cytoplasmic droplet consists of lipids, lipoproteins, RNAs, a variety of hydrolytic enzymes, receptors, ion channels, and Golgi-derived vesicles. The droplet may be involved in regulatory volume loss (RVD) at ejaculation, and in most species, though not in humans, the cytoplasmic droplet is lost at ejaculation. Note that the cytoplasmic droplet is distinct from \"excessive residual cytoplasm\" that sometimes remains in epididymal spermatozoa, particularly when spermiogenesis has been disrupted." [GOC:krc, GOC:vesicles, PMID:12672117, PMID:21076437, PMID:23159014]
synonym: "sperm residual cytoplasm" EXACT []
is_a: GO:0097223 ! sperm part
is_a: GO:0097708 ! intracellular vesicle
created_by: paola
creation_date: 2014-04-10T14:03:30Z

[Term]
id: GO:0097599
name: xylanase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of xylans, homopolysaccharides composed of xylose residues." [GOC:jh2, ISBN:81-7736-269-0]
synonym: "xylosidase activity" RELATED []
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds
created_by: paola
creation_date: 2014-05-06T13:46:48Z

[Term]
id: GO:0097600
name: exoxylanase activity
namespace: molecular_function
def: "A xylanase activity that acts on one of the ends of a xylan polymer which does not contain side chains." [GOC:jh2, ISBN:81-7736-269-0, PMID:16535010]
is_a: GO:0097599 ! xylanase activity
created_by: paola
creation_date: 2014-05-06T13:48:27Z

[Term]
id: GO:0097601
name: retina blood vessel maintenance
namespace: biological_process
def: "A retina homeostatic process preventing the degeneration of a retina blood vessel." [GOC:jh2, PMID:23093773]
synonym: "maintenance of choriocapillaris" NARROW []
synonym: "maintenance of retina blood vessel" EXACT []
synonym: "maintenance of retinal blood vessel" EXACT []
is_a: GO:0001895 ! retina homeostasis
created_by: paola
creation_date: 2014-05-11T18:42:24Z

[Term]
id: GO:0097602
name: cullin family protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any member of the cullin family, hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3)." [GOC:ha, InterPro:IPR016158, PMID:18698375]
synonym: "cullin binding" NARROW []
is_a: GO:0005515 ! protein binding
created_by: paola
creation_date: 2014-05-11T20:41:10Z

[Term]
id: GO:0097603
name: temperature-gated ion channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of an ion by a channel that opens in response to a temperature stimulus (e.g. exposure to a temperature range different than the optimal temperature for that organism)." [GOC:ha, GOC:pr, PMID:23027824]
synonym: "heat-activated ion channel activity" NARROW []
synonym: "temperature gated ion channel activity" EXACT []
synonym: "temperature-activated ion channel activity" EXACT []
synonym: "temperature-dependent ion channel activity" EXACT []
is_a: GO:0005216 ! ion channel activity
is_a: GO:0022836 ! gated channel activity
created_by: paola
creation_date: 2014-05-12T13:10:42Z

[Term]
id: GO:0097604
name: temperature-gated cation channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a cation by a channel that opens in response to a temperature stimulus (e.g. exposure to a temperature range different than the optimal temperature for that organism)." [GOC:ha, GOC:pr, PMID:23027824]
synonym: "heat-activated cation channel activity" NARROW []
synonym: "temperature gated cation channel activity" EXACT []
synonym: "temperature-activated cation channel activity" EXACT []
synonym: "temperature-dependent cation channel activity" EXACT []
is_a: GO:0005261 ! cation channel activity
is_a: GO:0097603 ! temperature-gated ion channel activity
created_by: paola
creation_date: 2014-05-12T13:13:46Z

[Term]
id: GO:0097605
name: regulation of nuclear envelope permeability
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by the nuclear envelope." [GOC:pr]
synonym: "regulation of nuclear membrane permeability" RELATED []
is_a: GO:0006998 ! nuclear envelope organization
is_a: GO:0065008 ! regulation of biological quality
created_by: paola
creation_date: 2014-05-14T15:41:44Z

[Term]
id: GO:0097606
name: positive regulation of nuclear envelope permeability
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the passage or uptake of molecules by the nuclear envelope." [GOC:pr]
synonym: "positive regulation of nuclear membrane permeability" RELATED []
is_a: GO:0046824 ! positive regulation of nucleocytoplasmic transport
is_a: GO:0097605 ! regulation of nuclear envelope permeability
relationship: positively_regulates GO:0006913 ! nucleocytoplasmic transport
created_by: paola
creation_date: 2014-05-14T15:43:06Z

[Term]
id: GO:0097607
name: negative regulation of nuclear envelope permeability
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the passage or uptake of molecules by the nuclear envelope." [GOC:pr]
synonym: "negative regulation of nuclear membrane permeability" RELATED []
is_a: GO:0097605 ! regulation of nuclear envelope permeability
created_by: paola
creation_date: 2014-05-14T15:43:47Z

[Term]
id: GO:0097608
name: transverse flagellum
namespace: cellular_component
def: "A motile cilium found in dinoflagellates. It coils around the cell and provides the forward thrust for motility. It is often contained in a furrow called the cingulum, and emerges from a flagellar pore located in the cingulum." [GOC:at, http://en.wikipedia.org/wiki/Dinoflagellate#Morphology, http://tolweb.org/Dinoflagellates/2445, http://www.sms.si.edu/irlspec/Phyl_Dinofl_Glossary.htm, ISBN:0632009152]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. In this case community usage refers to 'flagellum' rather than 'cilium', hence the primary term name, but the cilium parentage is deliberate.
synonym: "transverse cilium" EXACT []
is_a: GO:0031514 ! motile cilium
created_by: paola
creation_date: 2014-06-09T11:14:37Z

[Term]
id: GO:0097609
name: longitudinal flagellum
namespace: cellular_component
def: "A motile cilium found in dinoflagellates. It trails the cell and acts as a steering rudder. It is often partially contained in a furrow called the sulcus, and emerges from a flagellar pore located in the sulcus." [GOC:at, http://en.wikipedia.org/wiki/Dinoflagellate#Morphology, http://tolweb.org/Dinoflagellates/2445, http://www.sms.si.edu/irlspec/Phyl_Dinofl_Glossary.htm, ISBN:0632009152]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. In this case community usage refers to 'flagellum' rather than 'cilium', hence the primary term name, but the cilium parentage is deliberate.
synonym: "longitudinal cilium" EXACT []
is_a: GO:0031514 ! motile cilium
created_by: paola
creation_date: 2014-06-09T11:21:10Z

[Term]
id: GO:0097610
name: cell surface furrow
namespace: cellular_component
def: "A furrow that may be found on the cell surface. Examples are the cleavage furrow observed during cytokinesis in animal cells, and the cingulum and sulcus found in some dinoflagellates." [GOC:pr]
synonym: "cell surface groove" RELATED []
synonym: "furrow" BROAD []
synonym: "groove" BROAD []
is_a: GO:0044464 ! cell part
relationship: part_of GO:0009986 ! cell surface
created_by: paola
creation_date: 2014-06-09T11:22:38Z

[Term]
id: GO:0097611
name: dinoflagellate cingulum
namespace: cellular_component
def: "A cell surface furrow that wraps around a dinoflagellate cell; the transverse flagellum lies in it." [GOC:at, http://en.wikipedia.org/wiki/Dinoflagellate#Morphology, http://tolweb.org/Dinoflagellates/2445, http://www.sms.si.edu/irlspec/Phyl_Dinofl_Glossary.htm, ISBN:0632009152]
comment: The term name refers to a taxonomic group to make the label unique with respect to similarly-named anatomical structures.
synonym: "cingulum" BROAD []
synonym: "girdle" RELATED []
synonym: "transverse groove" RELATED []
is_a: GO:0097610 ! cell surface furrow
created_by: paola
creation_date: 2014-06-09T11:28:22Z

[Term]
id: GO:0097612
name: dinoflagellate sulcus
namespace: cellular_component
def: "A cell surface furrow that occurs on the ventral side of a dinoflagellate cell. It partially houses the longitudinal flagellum. The sulcus intersects with the cingulum on the ventral side of a dinoflagellate cell." [GOC:at, http://en.wikipedia.org/wiki/Dinoflagellate#Morphology, http://tolweb.org/Dinoflagellates/2445, http://www.sms.si.edu/irlspec/Phyl_Dinofl_Glossary.htm, ISBN:0632009152]
comment: The term name refers to a taxonomic group to make the label unique with respect to similarly-named anatomical structures. Also, the ventral (front) side of a dinoflagellate cell is the one where the sulcus is located (as opposed to the dorsal (back) side).
synonym: "longitudinal furrow" RELATED []
synonym: "longitudinal groove" RELATED []
synonym: "sulcus" BROAD []
is_a: GO:0097610 ! cell surface furrow
created_by: paola
creation_date: 2014-06-09T11:31:05Z

[Term]
id: GO:0097613
name: dinoflagellate epicone
namespace: cellular_component
def: "The part of a dinoflagellate cell above the cingulum; also referred to as the anterior portion of a dinoflagellate cell. It is separated from the hypocone by the cingulum." [GOC:at, http://en.wikipedia.org/wiki/Dinoflagellate#Morphology, http://tolweb.org/Dinoflagellates/2445, http://www.sms.si.edu/irlspec/Phyl_Dinofl_Glossary.htm, ISBN:0632009152]
comment: The term name refers to a taxonomic group to make the label unique with respect to similarly-named anatomical structures.
synonym: "epicone" BROAD []
synonym: "episome" RELATED []
synonym: "epitheca" RELATED []
is_a: GO:0044464 ! cell part
created_by: paola
creation_date: 2014-06-09T11:32:48Z

[Term]
id: GO:0097614
name: dinoflagellate hypocone
namespace: cellular_component
def: "The part of a dinoflagellate cell below the cingulum; also referred to as the posterior portion of a dinoflagellate cell. It is separated from the epicone by the cingulum." [GOC:at, http://en.wikipedia.org/wiki/Dinoflagellate#Morphology, http://tolweb.org/Dinoflagellates/2445, http://www.sms.si.edu/irlspec/Phyl_Dinofl_Glossary.htm, ISBN:0632009152]
comment: The term name refers to a taxonomic group to make the label unique with respect to similarly-named anatomical structures.
synonym: "hypocone" BROAD []
synonym: "hyposome" RELATED []
synonym: "hypotheca" RELATED []
is_a: GO:0044464 ! cell part
created_by: paola
creation_date: 2014-06-09T11:35:07Z

[Term]
id: GO:0097615
name: modulation by host of symbiont type IV pilus-dependent motility
namespace: biological_process
def: "The process in which an organism effects a change in the type IV pilus-dependent motility of a symbiont organism (i.e. the controlled movement of a bacterial cell which is dependent on the presence of type IV pili, and which includes social gliding motility and twitching motility). The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:als, PMID:12037568]
synonym: "modulation by host of bacterial type IV pilus-dependent motility" EXACT []
is_a: GO:0051851 ! modification by host of symbiont morphology or physiology
created_by: paola
creation_date: 2014-06-10T13:17:13Z

[Term]
id: GO:0097616
name: positive regulation by host of symbiont type IV pilus-dependent motility
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the type IV pilus-dependent motility of a symbiont organism (i.e. the controlled movement of a bacterial cell which is dependent on the presence of type IV pili, and which includes social gliding motility and twitching motility). The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:als, PMID:12037568]
synonym: "positive regulation by host of bacterial type IV pilus-dependent motility" EXACT []
is_a: GO:0097615 ! modulation by host of symbiont type IV pilus-dependent motility
created_by: paola
creation_date: 2014-06-10T13:19:51Z

[Term]
id: GO:0097617
name: annealing activity
namespace: molecular_function
def: "A nucleic acid binding activity that brings together complementary sequences of nucleic acids so that they pair by hydrogen bonds to form a double-stranded polynucleotide." [GOC:mba, http://en.wikipedia.org/wiki/Nucleic_acid_thermodynamics#Annealing]
comment: The term 'annealing' is often used to describe the binding of a DNA probe, or the binding of a primer to a DNA strand during a polymerase chain reaction. The term is also often used to describe the reformation (renaturation) of complementary strands that were separated by heat (thermally denatured). For example, proteins such as RAD52 can help DNA anneal. If at all possible, please annotate to the more specific terms GO:0036310 'annealing helicase activity', GO:0097098 'DNA/RNA hybrid annealing activity' or GO:0033592 'RNA strand annealing activity'.
synonym: "renaturation" RELATED []
is_a: GO:0003676 ! nucleic acid binding
created_by: paola
creation_date: 2014-06-13T10:18:43Z

[Term]
id: GO:0097618
name: dinoflagellate sulcal notch
namespace: cellular_component
def: "A dinoflagellate sulcus that extends all the way to the posterior end of the cell (also known as antapex). The presence of a sulcal notch makes the dinoflagellate hypocone appear bilobed." [GOC:at, http://en.wikipedia.org/wiki/Dinoflagellate#Morphology, http://tolweb.org/Dinoflagellates/2445, http://www.sms.si.edu/irlspec/Phyl_Dinofl_Glossary.htm, ISBN:0632009152]
comment: The term name refers to a taxonomic group to make the label unique with respect to similarly-named anatomical structures. Also, the ventral (front) side of a dinoflagellate cell is the one where the sulcus is located (as opposed to the dorsal (back) side). The term 'sulcal notch' appears mostly in older literature; more recently, indication of a bilobed hypocone is used to express the same.
synonym: "dinoflagellate sulcus notch" EXACT []
synonym: "sulcal notch" RELATED []
is_a: GO:0097612 ! dinoflagellate sulcus
created_by: paola
creation_date: 2014-06-27T16:28:49Z

[Term]
id: GO:0097619
name: PTEX complex
namespace: cellular_component
def: "A protein complex that acts as a protein trafficking machinery and is responsible for the export of proteins across the parasitophorous (symbiont-containing) vacuolar membrane and into the human host cell. The PTEX complex is located in the vacuole membrane. It is ATP-powered, and comprises heat shock protein 101 (HSP101; a ClpA/B-like ATPase from the AAA+ superfamily, of a type commonly associated with protein translocons), a parasite protein termed PTEX150, and exported protein 2 (EXP2). EXP2 is the potential channel, as it is the membrane-associated component of the core PTEX complex. Two other proteins, PTEX88 and thioredoxin 2 (TRX2), were also identified as PTEX components." [GOC:pr, PMID:19536257, PMID:25043010, PMID:25043043]
synonym: "Plasmodium translocon of exported proteins" RELATED []
is_a: GO:0033643 ! host cell part
is_a: GO:0043234 ! protein complex
is_a: GO:0044421 ! extracellular region part
is_a: GO:0044422 ! organelle part
relationship: part_of GO:0020005 ! symbiont-containing vacuole membrane
created_by: paola
creation_date: 2014-07-29T16:05:32Z

[Term]
id: GO:0097620
name: (R)-mandelate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-2-hydroxy-2-phenylacetate + acceptor = phenylglyoxylate + reduced acceptor." [GOC:pr, PMID:1731758, RHEA:43112]
comment: In the yeast Rhodotorula graminis, (R)-mandelate dehydrogenase is the first enzyme of the mandelate pathway, and catalyzes the NAD-dependent oxidation of (R)-mandelate to phenylglyoxylate.
synonym: "D-mandelate dehydrogenase activity" EXACT []
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors
created_by: paola
creation_date: 2014-07-30T09:53:23Z

[Term]
id: GO:0097621
name: monoamine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2." [EC:1.4.3.4, GOC:pr, RHEA:26417]
comment: Acts on primary amines, and also on some secondary and tertiary amines. It differs from EC 1.4.3.21, primary-amine oxidase as it can oxidize secondary and tertiary amines but not methylamine.
synonym: "amine:oxygen oxidoreductase (deaminating) activity" EXACT []
is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
created_by: paola
creation_date: 2014-07-30T10:23:57Z

[Term]
id: GO:0097622
name: cytoplasmic translational elongation through polyproline stretches
namespace: biological_process
def: "The successive addition of amino acid residues to a nascent polypeptide chain, proceeding through regions of multiple repeated proline codons, during protein biosynthesis in the cytoplasm." [GOC:mcc, PMID:24923804]
is_a: GO:0002182 ! cytoplasmic translational elongation
created_by: paola
creation_date: 2014-08-06T16:29:10Z

[Term]
id: GO:0097623
name: potassium ion export across plasma membrane
namespace: biological_process
def: "The directed movement of potassium ions from inside of a cell, across the plasma membrane and into the extracellular region." [GOC:vw, PMID:11932440]
synonym: "potassium export across plasma membrane" BROAD []
is_a: GO:0071435 ! potassium ion export
created_by: paola
creation_date: 2014-08-06T17:03:45Z

[Term]
id: GO:0097624
name: UDP-galactose transmembrane import into Golgi lumen
namespace: biological_process
def: "The directed movement of UDP-galactose into the Golgi lumen across the Golgi membrane." [GOC:vw, PMID:11378902]
synonym: "UDP-galactose import into Golgi lumen" BROAD []
is_a: GO:0072334 ! UDP-galactose transmembrane transport
is_a: GO:1902582 ! single-organism intracellular transport
created_by: paola
creation_date: 2014-08-18T14:59:23Z

[Term]
id: GO:0097625
name: low-affinity basic amino acid transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of basic amino acids from one side of a membrane to the other. Basic amino acids have a pH above 7. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [GOC:pr]
synonym: "low affinity basic amino acid transmembrane transporter activity" EXACT []
is_a: GO:0015174 ! basic amino acid transmembrane transporter activity
created_by: paola
creation_date: 2014-08-20T14:23:18Z

[Term]
id: GO:0097626
name: low-affinity L-arginine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of L-arginine from one side of a membrane to the other. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [GOC:krc, PMID:8195186]
synonym: "low affinity L-arginine transmembrane transporter activity" EXACT []
is_a: GO:0061459 ! L-arginine transmembrane transporter activity
is_a: GO:0097625 ! low-affinity basic amino acid transmembrane transporter activity
created_by: paola
creation_date: 2014-08-20T14:24:22Z

[Term]
id: GO:0097627
name: high-affinity L-ornithine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of L-ornithine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:krc, PMID:8195186]
synonym: "high affinity L-ornithine transmembrane transporter activity" EXACT []
is_a: GO:0000064 ! L-ornithine transmembrane transporter activity
created_by: paola
creation_date: 2014-08-20T14:26:33Z

[Term]
id: GO:0097628
name: distal tip cell migration
namespace: biological_process
def: "The orderly movement of a distal tip cell." [CL:0000661, GOC:mm2, PMID:24968003]
is_a: GO:0016477 ! cell migration
created_by: paola
creation_date: 2014-08-20T16:06:53Z

[Term]
id: GO:0097629
name: extrinsic component of omegasome membrane
namespace: cellular_component
def: "The component of the omegasome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:mf, PMID:18725538, PMID:24591649]
synonym: "extrinsic to omegasome membrane" EXACT []
synonym: "omegasome peripheral membrane" RELATED []
is_a: GO:0031312 ! extrinsic component of organelle membrane
is_a: GO:0044444 ! cytoplasmic part
intersection_of: GO:0019898 ! extrinsic component of membrane
intersection_of: part_of GO:1903349 ! omegasome membrane
relationship: part_of GO:1903349 ! omegasome membrane

[Term]
id: GO:0097630
name: intrinsic component of omegasome membrane
namespace: cellular_component
def: "The component of the omegasome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:mf, PMID:18725538, PMID:24591649]
synonym: "intrinsic to omegasome membrane" NARROW []
is_a: GO:0031300 ! intrinsic component of organelle membrane
is_a: GO:0044444 ! cytoplasmic part
intersection_of: GO:0031224 ! intrinsic component of membrane
intersection_of: part_of GO:1903349 ! omegasome membrane
relationship: part_of GO:1903349 ! omegasome membrane

[Term]
id: GO:0097631
name: integral component of omegasome membrane
namespace: cellular_component
def: "The component of the omegasome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:mf, PMID:18725538, PMID:24591649]
synonym: "integral to omegasome membrane" NARROW []
synonym: "omegasome integral membrane protein" RELATED []
is_a: GO:0031301 ! integral component of organelle membrane
is_a: GO:0097630 ! intrinsic component of omegasome membrane
intersection_of: GO:0016021 ! integral component of membrane
intersection_of: part_of GO:1903349 ! omegasome membrane
relationship: part_of GO:1903349 ! omegasome membrane

[Term]
id: GO:0097632
name: extrinsic component of pre-autophagosomal structure membrane
namespace: cellular_component
def: "The component of the pre-autophagosomal structure membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:mf]
synonym: "extrinsic to pre-autophagosomal structure membrane" EXACT []
synonym: "pre-autophagosomal structure peripheral membrane" RELATED []
is_a: GO:0031312 ! extrinsic component of organelle membrane
is_a: GO:0044444 ! cytoplasmic part
intersection_of: GO:0019898 ! extrinsic component of membrane
intersection_of: part_of GO:0034045 ! pre-autophagosomal structure membrane
relationship: part_of GO:0034045 ! pre-autophagosomal structure membrane

[Term]
id: GO:0097633
name: intrinsic component of pre-autophagosomal structure membrane
namespace: cellular_component
def: "The component of the pre-autophagosomal structure membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:mf]
synonym: "intrinsic to pre-autophagosomal structure membrane" NARROW []
is_a: GO:0031300 ! intrinsic component of organelle membrane
is_a: GO:0044444 ! cytoplasmic part
intersection_of: GO:0031224 ! intrinsic component of membrane
intersection_of: part_of GO:0034045 ! pre-autophagosomal structure membrane
relationship: part_of GO:0034045 ! pre-autophagosomal structure membrane

[Term]
id: GO:0097634
name: integral component of pre-autophagosomal structure membrane
namespace: cellular_component
def: "The component of the pre-autophagosomal structure membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:mf]
synonym: "integral to pre-autophagosomal structure membrane" NARROW []
synonym: "pre-autophagosomal structure integral membrane protein" RELATED []
is_a: GO:0031301 ! integral component of organelle membrane
is_a: GO:0097633 ! intrinsic component of pre-autophagosomal structure membrane
intersection_of: GO:0016021 ! integral component of membrane
intersection_of: part_of GO:0034045 ! pre-autophagosomal structure membrane
relationship: part_of GO:0034045 ! pre-autophagosomal structure membrane

[Term]
id: GO:0097635
name: extrinsic component of autophagosome membrane
namespace: cellular_component
def: "The component of the autophagosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:autophagy, GOC:mf]
synonym: "autophagic vacuole peripheral membrane" RELATED []
synonym: "extrinsic component of autophagic vacuole membrane" EXACT [GOC:autophagy]
synonym: "extrinsic to autophagic vacuole membrane" EXACT []
is_a: GO:0000306 ! extrinsic component of vacuolar membrane
intersection_of: GO:0019898 ! extrinsic component of membrane
intersection_of: part_of GO:0000421 ! autophagosome membrane
relationship: part_of GO:0000421 ! autophagosome membrane

[Term]
id: GO:0097636
name: intrinsic component of autophagosome membrane
namespace: cellular_component
def: "The component of the autophagosome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:autophagy, GOC:mf]
synonym: "intrinsic component of autophagic vacuole membrane" EXACT [GOC:autophagy]
synonym: "intrinsic to autophagic vacuole membrane" NARROW []
is_a: GO:0031310 ! intrinsic component of vacuolar membrane
intersection_of: GO:0031224 ! intrinsic component of membrane
intersection_of: part_of GO:0000421 ! autophagosome membrane
relationship: part_of GO:0000421 ! autophagosome membrane

[Term]
id: GO:0097637
name: integral component of autophagosome membrane
namespace: cellular_component
def: "The component of the autophagosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:autophagy, GOC:mf]
synonym: "autophagic vacuole integral membrane protein" RELATED []
synonym: "integral component of autophagic vacuole membrane" EXACT [GOC:autophagy]
synonym: "integral to autophagic vacuole membrane" NARROW []
is_a: GO:0031166 ! integral component of vacuolar membrane
is_a: GO:0097636 ! intrinsic component of autophagosome membrane
intersection_of: GO:0016021 ! integral component of membrane
intersection_of: part_of GO:0000421 ! autophagosome membrane
relationship: part_of GO:0000421 ! autophagosome membrane

[Term]
id: GO:0097638
name: L-arginine import across plasma membrane
namespace: biological_process
def: "The directed movement of L-arginine from outside of a cell, across the plasma membrane and into the cytosol." [GOC:krc, PMID:8195186]
is_a: GO:0089718 ! amino acid import across plasma membrane
is_a: GO:1902765 ! L-arginine import into cell
is_a: GO:1903400 ! L-arginine transmembrane transport

[Term]
id: GO:0097639
name: L-lysine import across plasma membrane
namespace: biological_process
def: "The directed movement of L-lysine from outside of a cell, across the plasma membrane and into the cytosol." [GOC:krc, PMID:8195186]
is_a: GO:0089718 ! amino acid import across plasma membrane
is_a: GO:1903401 ! L-lysine transmembrane transport
is_a: GO:1903410 ! L-lysine import into cell

[Term]
id: GO:0097640
name: L-ornithine import across plasma membrane
namespace: biological_process
def: "The directed movement of L-ornithine from outside of a cell, across the plasma membrane and into the cytosol." [GOC:krc, PMID:8195186]
is_a: GO:0089718 ! amino acid import across plasma membrane
is_a: GO:1903352 ! L-ornithine transmembrane transport
is_a: GO:1903411 ! L-ornithine import into cell

[Term]
id: GO:0097641
name: alpha-ketoglutarate-dependent xanthine dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate (alpha-ketoglutarate) + O2 + xanthine = CO2 + succinate + urate." [GOC:vw, PMID:15948966, PMID:17429948, RHEA:43120]
synonym: "2-oxoglutarate-dependent xanthine dioxygenase activity" EXACT []
synonym: "alpha-ketoglutarate- and Fe(II)-dependent xanthine dioxygenase activity" RELATED []
synonym: "alpha-ketoglutarate- and Fe(II)-dependent xanthine hydroxylase activity" RELATED []
is_a: GO:0051213 ! dioxygenase activity
created_by: paola
creation_date: 2014-09-03T14:55:42Z

[Term]
id: GO:0097642
name: calcitonin family receptor activity
namespace: molecular_function
def: "Combining with any member of the calcitonin family (e.g. adrenomedullin, adrenomedullin 2 (intermedin), amylin, calcitonin and calcitonin gene-related peptides (CGRPs)) to initiate a change in cell activity." [GOC:bhm, InterPro:IPR003287, PMID:10871296, PMID:12037140, PMID:18687416]
is_a: GO:0008528 ! G-protein coupled peptide receptor activity
created_by: paola
creation_date: 2014-09-08T15:32:19Z

[Term]
id: GO:0097643
name: amylin receptor activity
namespace: molecular_function
def: "Combining with amylin to initiate a change in cell activity." [GOC:bhm, PMID:10871296, PMID:12037140, PMID:18687416]
is_a: GO:0097642 ! calcitonin family receptor activity
created_by: paola
creation_date: 2014-09-08T15:34:16Z

[Term]
id: GO:0097644
name: calcitonin family binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any member of the calcitonin family (e.g. adrenomedullin, adrenomedullin 2 (intermedin), amylin, calcitonin and calcitonin gene-related peptides (CGRPs))." [GOC:bhm, InterPro:IPR021116, PMID:10871296, PMID:12037140, PMID:18687416]
is_a: GO:0017046 ! peptide hormone binding
created_by: paola
creation_date: 2014-09-08T20:50:52Z

[Term]
id: GO:0097645
name: amylin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with amylin." [GOC:bhm, PMID:10871296, PMID:12037140, PMID:18687416]
is_a: GO:0097644 ! calcitonin family binding
created_by: paola
creation_date: 2014-09-08T20:53:03Z

[Term]
id: GO:0097646
name: calcitonin family receptor signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by an extracellular member of the calcitonin family (e.g. adrenomedullin, adrenomedullin 2 (intermedin), amylin, calcitonin and calcitonin gene-related peptides (CGRPs)) combining with a calcitonin family receptor on the surface of the target cell. Calcitonin family receptors may form dimers, trimers or tetramers; adrenomedullin and amylin receptors have only been observed as dimers so far." [GOC:bhm, PMID:10871296, PMID:12037140, PMID:18687416]
synonym: "calcitonin family receptor signalling pathway" EXACT []
is_a: GO:0007186 ! G-protein coupled receptor signaling pathway
created_by: paola
creation_date: 2014-09-09T17:48:05Z

[Term]
id: GO:0097647
name: amylin receptor signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by an extracellular amylin combining with a dimeric amylin receptor on the surface of the target cell." [GOC:bhm, PMID:10871296, PMID:12037140, PMID:18687416]
synonym: "amilyn receptor signalling pathway" EXACT []
is_a: GO:0038042 ! dimeric G-protein coupled receptor signaling pathway
is_a: GO:0097646 ! calcitonin family receptor signaling pathway
created_by: paola
creation_date: 2014-09-09T17:49:52Z

[Term]
id: GO:0097648
name: G-protein coupled receptor complex
namespace: cellular_component
def: "A protein complex that contains G-protein coupled receptors." [GOC:bhm]
is_a: GO:0098802 ! plasma membrane receptor complex
relationship: part_of GO:0005887 ! integral component of plasma membrane
created_by: paola
creation_date: 2014-09-10T09:14:30Z

[Term]
id: GO:0097649
name: A axonemal microtubule
namespace: cellular_component
def: "A complete microtubule with 13 protofilaments that fuses with an incomplete microtubule called B tubule (containing 10 protofilaments only) to form an axonemal outer doublet. Inner and outer dynein arms, as well as the radial spoke, are attached to the A tubule." [GOC:cilia, ISBN:0716731363]
synonym: "A tubule" BROAD []
is_a: GO:0005879 ! axonemal microtubule
relationship: part_of GO:0097545 ! axonemal outer doublet
created_by: paola
creation_date: 2014-09-10T20:41:28Z

[Term]
id: GO:0097650
name: B axonemal microtubule
namespace: cellular_component
def: "An incomplete microtubule containing 10 protofilaments that fuses with a complete microtubule called A tubule (containing 13 protofilaments) to form an axonemal outer doublet." [GOC:cilia, ISBN:0716731363]
synonym: "B tubule" BROAD []
is_a: GO:0005879 ! axonemal microtubule
relationship: part_of GO:0097545 ! axonemal outer doublet
created_by: paola
creation_date: 2014-09-10T20:43:18Z

[Term]
id: GO:0097651
name: phosphatidylinositol 3-kinase complex, class I
namespace: cellular_component
def: "A phosphatidylinositol 3-kinase complex that contains a catalytic and a regulatory subunit of a phosphatidylinositol 3-kinase (PI3K) enzyme, plus one or more adaptor proteins. Class I PI3Ks phosphorylate phosphatidylinositol [PI], phosphatidylinositol-4-phosphate [PI(4)P] and phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2], and are divided into subclasses A and B according to the type of adaptor subunit with which they associate. The class I PI3K subfamily of genes comprises members in vertebrates, worm and fly, but none in yeast." [GOC:ha, PMID:24587488]
synonym: "class I phosphatidylinositol 3-kinase complex" EXACT []
synonym: "class I PI3K complex" EXACT []
is_a: GO:0005942 ! phosphatidylinositol 3-kinase complex
created_by: paola
creation_date: 2014-09-16T11:19:58Z

[Term]
id: GO:0097652
name: phosphatidylinositol 3-kinase complex, class II
namespace: cellular_component
def: "A phosphatidylinositol 3-kinase complex that contains a catalytic subunit of a phosphatidylinositol 3-kinase (PI3K) enzyme and one or more adaptor proteins. There is no known obligatory regulatory subunit. The class II PI3K (PI3KC2) subfamily of genes has members in vertebrates, worm and fly, but none in yeast." [GOC:ha, PMID:24587488]
synonym: "class II phosphatidylinositol 3-kinase complex" EXACT []
synonym: "class II PI3K complex" EXACT []
is_a: GO:0005942 ! phosphatidylinositol 3-kinase complex
created_by: paola
creation_date: 2014-09-16T13:14:17Z

[Term]
id: GO:0097653
name: unencapsulated part of cell
namespace: cellular_component
def: "The part of a cell encompassing the intracellular environment and the plasma membrane; it excludes any external encapsulating structures." [GOC:curators]
synonym: "non-encapsulated part of cell" EXACT []
is_a: GO:0044464 ! cell part
relationship: has_part GO:0005622 ! intracellular
relationship: has_part GO:0005886 ! plasma membrane
created_by: paola
creation_date: 2014-09-23T12:57:14Z

[Term]
id: GO:0097654
name: platelet SNARE complex
namespace: cellular_component
def: "A SNARE complex that is capable of fusing intracellular vesicles to the plasma membrane of platelets for exocytosis of alpha-granules or dense granules. Contains isoforms of VAMP, SNAP and syntaxin proteins. Ternary SNARE complexes interact in a circular array to form ring complexes or channels around the membrane fusion. A common composition in human is VAMP-8, SNAP-23 and syntaxin-2 or -4." [GOC:bhm, PMID:12130530, PMID:19450911]
is_a: GO:0031201 ! SNARE complex
created_by: paola
creation_date: 2014-09-24T13:50:49Z

[Term]
id: GO:0097655
name: serpin family protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any member of the serpin protein family (serine protease inhibitors or classified inhibitor family I4). Serpins are a broadly distributed family of protease inhibitors that use a conformational change to inhibit target enzymes. They are central in controlling many important proteolytic cascades. The majority of serpins inhibit serine proteases, but serpins that inhibit caspases and papain-like cysteine proteases have also been identified. Rarely, serpins perform a non-inhibitory function; for example, several human serpins function as hormone transporters and certain serpins function as molecular chaperones or tumor suppressors." [GOC:mr, InterPro:IPR000215, PMID:16737556]
synonym: "SERPIN family protein binding" EXACT []
is_a: GO:0005515 ! protein binding
created_by: paola
creation_date: 2014-09-24T16:19:31Z

[Term]
id: GO:0097656
name: cell-cell self recognition
namespace: biological_process
def: "A cell-cell recognition process by which a cell distinguishes between self and non self during cooperative behavior, such as early development." [GOC:pf, PMID:21700835, PMID:23910661]
comment: Examples are the membrane proteins TgrB1 and TgrC1 in the social amoeba Dictyostelium discoideum.
synonym: "kin discrimination" RELATED []
synonym: "kin recognition" BROAD []
synonym: "self recognition" BROAD []
is_a: GO:0009988 ! cell-cell recognition
created_by: paola
creation_date: 2014-09-24T20:58:35Z

[Term]
id: GO:0097657
name: 3',5'-nucleotide bisphosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3',5'-nucleotide bisphosphate + H20 = 5'-nucleotide monophosphate + phosphate." [GOC:jh2, PMID:24401123, RHEA:43532]
is_a: GO:0016791 ! phosphatase activity
created_by: paola
creation_date: 2014-09-25T11:21:39Z

[Term]
id: GO:0097658
name: Asi complex
namespace: cellular_component
def: "A nuclear ubiquitin ligase multiprotein complex located in the inner nuclear membrane (INM) that recognizes and ubiquitinates misfolded INM proteins and also some proteins involved in sterol biosynthesis, during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligases Asi1p and Asi3p." [GOC:mcc, PMID:25236469]
is_a: GO:0000152 ! nuclear ubiquitin ligase complex
is_a: GO:0044453 ! nuclear membrane part
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0005637 ! nuclear inner membrane
created_by: paola
creation_date: 2014-09-29T15:08:29Z

[Term]
id: GO:0097659
name: nucleic acid-templated transcription
namespace: biological_process
def: "The cellular synthesis of RNA on a template of nucleic acid (DNA or RNA)." [GOC:pr, GOC:txnOH, GOC:vw]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
is_a: GO:0032774 ! RNA biosynthetic process
created_by: paola
creation_date: 2014-10-01T13:49:27Z

[Term]
id: GO:0097660
name: SCF-Cdc4 ubiquitin ligase complex
namespace: cellular_component
def: "An SCF ubiquitin ligase complex in which the F-box protein is Cdc4 in S. cerevisiae." [GOC:jd, GOC:vw, PMID:9346238]
is_a: GO:0019005 ! SCF ubiquitin ligase complex
created_by: paola
creation_date: 2014-10-06T10:23:13Z

[Term]
id: GO:0097661
name: SCF-Ctf13 ubiquitin ligase complex
namespace: cellular_component
def: "An SCF ubiquitin ligase complex in which the F-box protein is Ctf13 in S. cerevisiae." [GOC:jd, GOC:vw, PMID:14747994]
is_a: GO:0019005 ! SCF ubiquitin ligase complex
created_by: paola
creation_date: 2014-10-06T10:25:56Z

[Term]
id: GO:0097662
name: SCF-Das1 ubiquitin ligase complex
namespace: cellular_component
def: "An SCF ubiquitin ligase complex in which the F-box protein is Das1 in S. cerevisiae." [GOC:jd, GOC:vw, PMID:14747994]
is_a: GO:0019005 ! SCF ubiquitin ligase complex
created_by: paola
creation_date: 2014-10-06T10:26:27Z

[Term]
id: GO:0097663
name: SCF-Dia2/Pof3 ubiquitin ligase complex
namespace: cellular_component
def: "An SCF ubiquitin ligase complex in which the F-box protein is Dia2 in S. cerevisiae (Pof3 in S. pombe)." [GOC:jd, GOC:vw, PMID:14747994, PMID:15147268]
is_a: GO:0019005 ! SCF ubiquitin ligase complex
created_by: paola
creation_date: 2014-10-06T10:26:44Z

[Term]
id: GO:0097664
name: SCF-Grr1/Pof2 ubiquitin ligase complex
namespace: cellular_component
def: "An SCF ubiquitin ligase complex in which the F-box protein is Grr1 in S. cerevisiae (Pof2 in S. pombe)." [GOC:jd, GOC:vw, PMID:10213692, PMID:15147268]
is_a: GO:0019005 ! SCF ubiquitin ligase complex
created_by: paola
creation_date: 2014-10-06T10:27:10Z

[Term]
id: GO:0097665
name: SCF-Mdm30 ubiquitin ligase complex
namespace: cellular_component
def: "An SCF ubiquitin ligase complex in which the F-box protein is Mdm30 in S. cerevisiae." [GOC:jd, GOC:vw, PMID:14747994]
is_a: GO:0019005 ! SCF ubiquitin ligase complex
created_by: paola
creation_date: 2014-10-06T10:27:30Z

[Term]
id: GO:0097666
name: SCF-Met30/Pof1 ubiquitin ligase complex
namespace: cellular_component
def: "An SCF ubiquitin ligase complex in which the F-box protein is Met30 in S. cerevisiae (Pof1 in S pombe)." [GOC:jd, GOC:vw, PMID:15147268, PMID:9499404]
is_a: GO:0019005 ! SCF ubiquitin ligase complex
created_by: paola
creation_date: 2014-10-06T10:27:49Z

[Term]
id: GO:0097667
name: SCF-Rcy1/Pof6 ubiquitin ligase complex
namespace: cellular_component
def: "An SCF ubiquitin ligase complex in which the F-box protein is Rcy1 in S. cerevisiae (Pof6 in S. pombe)." [GOC:jd, GOC:vw, PMID:14747994, PMID:15147268]
is_a: GO:0019005 ! SCF ubiquitin ligase complex
created_by: paola
creation_date: 2014-10-06T10:28:09Z

[Term]
id: GO:0097668
name: SCF-Saf1/Pof9 ubiquitin ligase complex
namespace: cellular_component
def: "An SCF ubiquitin ligase complex in which the F-box protein is Saf1 in S. cerevisiae (Pof9 in S. pombe)." [GOC:jd, GOC:vw, PMID:11283612, PMID:15147268]
is_a: GO:0019005 ! SCF ubiquitin ligase complex
created_by: paola
creation_date: 2014-10-06T10:28:30Z

[Term]
id: GO:0097669
name: SCF-Skp2 ubiquitin ligase complex
namespace: cellular_component
def: "An SCF ubiquitin ligase complex in which the F-box protein is Skp2 in S. cerevisiae." [GOC:jd, GOC:vw, PMID:14747994]
is_a: GO:0019005 ! SCF ubiquitin ligase complex
created_by: paola
creation_date: 2014-10-06T10:28:52Z

[Term]
id: GO:0097670
name: SCF-Ufo1/Pof10 ubiquitin ligase complex
namespace: cellular_component
def: "An SCF ubiquitin ligase complex in which the F-box protein is Ufo1 in S. cerevisiae (Pof10 in S. pombe)." [GOC:jd, GOC:vw, PMID:14747994, PMID:15147268]
is_a: GO:0019005 ! SCF ubiquitin ligase complex
created_by: paola
creation_date: 2014-10-06T10:29:13Z

[Term]
id: GO:0097671
name: SCF-YDR131C ubiquitin ligase complex
namespace: cellular_component
def: "An SCF ubiquitin ligase complex in which the F-box protein is YDR131C in S. cerevisiae." [GOC:jd, GOC:vw, PMID:14747994]
is_a: GO:0019005 ! SCF ubiquitin ligase complex
created_by: paola
creation_date: 2014-10-06T10:29:35Z

[Term]
id: GO:0097672
name: SCF-Pof5 ubiquitin ligase complex
namespace: cellular_component
def: "An SCF ubiquitin ligase complex in which the F-box protein is Pof5 in S. pombe (YDR306C in S. cerevisiae)." [GOC:jd, GOC:vw, PMID:14747994, PMID:15147268]
synonym: "SCF-YDR306C ubiquitin ligase complex" RELATED []
is_a: GO:0019005 ! SCF ubiquitin ligase complex
created_by: paola
creation_date: 2014-10-06T10:30:10Z

[Term]
id: GO:0097673
name: SCF-Ucc1 ubiquitin ligase complex
namespace: cellular_component
def: "An SCF ubiquitin ligase complex in which the F-box protein is YLR224W in S. cerevisiae." [GOC:jd, GOC:vw, PMID:14747994, PMID:25982115]
synonym: "SCF-YLR224W ubiquitin ligase complex" EXACT [PMID:14747994]
is_a: GO:0019005 ! SCF ubiquitin ligase complex
created_by: paola
creation_date: 2014-10-06T10:30:31Z

[Term]
id: GO:0097674
name: SCF-YLR352W ubiquitin ligase complex
namespace: cellular_component
def: "An SCF ubiquitin ligase complex in which the F-box protein is YLR352W in S. cerevisiae." [GOC:jd, GOC:vw, PMID:19882662]
is_a: GO:0019005 ! SCF ubiquitin ligase complex
created_by: paola
creation_date: 2014-10-06T10:30:54Z

[Term]
id: GO:0097675
name: SCF-Hrt3/Pof7 ubiquitin ligase complex
namespace: cellular_component
def: "An SCF ubiquitin ligase complex in which the F-box protein is Hrt3 in S. cerevisiae (Pof7 in S. pombe)." [GOC:jd, GOC:vw, PMID:14747994, PMID:15147268]
is_a: GO:0019005 ! SCF ubiquitin ligase complex
created_by: paola
creation_date: 2014-10-06T10:31:14Z

[Term]
id: GO:0097676
name: histone H3-K36 dimethylation
namespace: biological_process
def: "The modification of histone H3 by addition of two methyl groups to lysine at position 36 of the histone." [GOC:lb, PMID:21187428]
is_a: GO:0010452 ! histone H3-K36 methylation
is_a: GO:0018027 ! peptidyl-lysine dimethylation
created_by: paola
creation_date: 2014-11-04T10:38:05Z

[Term]
id: GO:0097677
name: STAT family protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any member of the signal transducers and activators of transcription (STAT) protein family. STATs are, as the name indicates, both signal transducers and transcription factors. STATs are activated by cytokines and some growth factors and thus control important biological processes including cell growth, cell differentiation, apoptosis and immune responses." [GOC:mr, InterPro:IPR001217, PMID:21447371, PMID:24470978]
synonym: "signal transducers and activators of transcription family protein binding" EXACT []
is_a: GO:0005515 ! protein binding
created_by: paola
creation_date: 2014-11-04T11:31:03Z

[Term]
id: GO:0097678
name: SOCS family protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any member of the suppressor of cytokine signaling (SOCS) family of proteins. SOCS represent an important mechanism to extinguish cytokine and growth factor receptor signaling. Individual SOCS proteins are typically induced by specific cytokines and growth factors, thereby generating a negative feedback loop. SOCS proteins have important functions in development and homeostasis, and in disease, particularly tumor suppression and anti-inflammatory functions." [GOC:mr, InterPro:IPR028413, PMID:23885323, PMID:24705897]
synonym: "suppressor of cytokine signaling family protein binding" EXACT []
is_a: GO:0005515 ! protein binding
created_by: paola
creation_date: 2014-11-04T11:32:49Z

[Term]
id: GO:0097679
name: other organism cytoplasm
namespace: cellular_component
def: "The cytoplasm of a secondary organism with which the first organism is interacting." [GOC:aa, PMID:23469034]
is_a: GO:0033643 ! host cell part
relationship: part_of GO:0044216 ! other organism cell
created_by: paola
creation_date: 2014-12-01T14:14:21Z

[Term]
id: GO:0097680
name: double-strand break repair via classical nonhomologous end joining
namespace: biological_process
def: "An instance of double-strand break repair via nonhomologous end joining that requires a number of factors important for V(D)J recombination, including the KU70/80 heterodimer (KU), XRCC4, ligase IV, and DNA-PKcs in mammals. It does not produce translocations (as opposed to the alternative nonhomologous end joining)." [GOC:rph, PMID:18584027]
synonym: "C-NHEJ" RELATED []
synonym: "canonical nonhomologous end joining" EXACT []
is_a: GO:0006303 ! double-strand break repair via nonhomologous end joining
created_by: paola
creation_date: 2014-12-17T15:15:18Z

[Term]
id: GO:0097681
name: double-strand break repair via alternative nonhomologous end joining
namespace: biological_process
def: "An instance of double-strand break repair via nonhomologous end joining that is independent of factors important for V(D)J recombination (as opposed to classical nonhomologous end joining). It often results in a deletion with microhomology (i.e. 5-25bp homology) at the repair junction. Among different subclasses of nonhomologous end joining (NHEJ), alternative NHEJ appears to play a significant role in the etiology of mutations that arise during cancer development and treatment." [GOC:rph, http://en.wikipedia.org/wiki/Microhomology-mediated_end_joining, PMID:18584027, PMID:21655080]
synonym: "A-NHEJ" RELATED []
synonym: "alt-NHEJ" RELATED []
synonym: "double-strand break repair via microhomology-mediated end joining" EXACT []
synonym: "MMEJ" RELATED []
is_a: GO:0006303 ! double-strand break repair via nonhomologous end joining
created_by: paola
creation_date: 2014-12-17T15:17:45Z

[Term]
id: GO:0097682
name: intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of cations by a channel that opens when phosphatidylinositol-3,5-bisphosphate has been bound by the channel complex or one of its constituent parts." [GOC:ha, PMID:24375408]
is_a: GO:0005217 ! intracellular ligand-gated ion channel activity
is_a: GO:0005261 ! cation channel activity
created_by: paola
creation_date: 2014-12-17T16:50:30Z

[Term]
id: GO:0097683
name: dinoflagellate apex
namespace: cellular_component
def: "The anterior most point of a dinoflagellate epicone." [GOC:at, http://en.wikipedia.org/wiki/Dinoflagellate#Morphology, http://tolweb.org/Dinoflagellates/2445, http://www.sms.si.edu/irlspec/Phyl_Dinofl_Glossary.htm, ISBN:0632009152]
comment: The term name refers to a taxonomic group to make the label unique with respect to similarly-named anatomical structures.
synonym: "apex" BROAD []
is_a: GO:0044464 ! cell part
relationship: part_of GO:0097613 ! dinoflagellate epicone
created_by: paola
creation_date: 2014-12-18T09:29:51Z

[Term]
id: GO:0097684
name: dinoflagellate antapex
namespace: cellular_component
def: "The anterior most point of a dinoflagellate hypocone." [GOC:at, http://en.wikipedia.org/wiki/Dinoflagellate#Morphology, http://tolweb.org/Dinoflagellates/2445, http://www.sms.si.edu/irlspec/Phyl_Dinofl_Glossary.htm, ISBN:0632009152]
comment: The term name refers to a taxonomic group to make the label unique with respect to similarly-named anatomical structures.
synonym: "antapex" BROAD []
is_a: GO:0044464 ! cell part
relationship: part_of GO:0097614 ! dinoflagellate hypocone
created_by: paola
creation_date: 2014-12-18T09:32:10Z

[Term]
id: GO:0097685
name: dinoflagellate apical groove
namespace: cellular_component
def: "A cell surface furrow (or groove) found on a dinoflagellate apex. It typically loops around the apex." [GOC:at, http://en.wikipedia.org/wiki/Dinoflagellate#Morphology, http://tolweb.org/Dinoflagellates/2445, http://www.sms.si.edu/irlspec/Phyl_Dinofl_Glossary.htm, ISBN:0632009152]
comment: The term name refers to a taxonomic group to make the label unique with respect to similarly-named anatomical structures.
synonym: "apical groove" BROAD []
is_a: GO:0097610 ! cell surface furrow
relationship: part_of GO:0097613 ! dinoflagellate epicone
created_by: paola
creation_date: 2014-12-18T09:34:52Z

[Term]
id: GO:0097686
name: dinoflagellate apical horn
namespace: cellular_component
def: "A horn-shaped dinoflagellate apex found in thecate species." [GOC:at, http://species-identification.org]
is_a: GO:0097683 ! dinoflagellate apex
created_by: paola
creation_date: 2014-12-18T09:38:15Z

[Term]
id: GO:0097687
name: dinoflagellate antapical horn
namespace: cellular_component
def: "A horn-shaped dinoflagellate antapex found in thecate species." [GOC:at, http://species-identification.org]
is_a: GO:0097684 ! dinoflagellate antapex
created_by: paola
creation_date: 2014-12-18T09:39:57Z

[Term]
id: GO:0097688
name: glutamate receptor clustering
namespace: biological_process
def: "The neurotransmitter-gated ion channel clustering process in which glutamate receptors are localized to distinct domains in the cell membrane." [GOC:krc, PMID:19723286]
synonym: "glutamatergic receptor clustering" EXACT []
is_a: GO:0072578 ! neurotransmitter-gated ion channel clustering
created_by: paola
creation_date: 2015-02-11T11:49:13Z

[Term]
id: GO:0097689
name: iron channel activity
namespace: molecular_function
def: "Enables the facilitated diffusion of an iron ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:kom, GOC:pr, PMID:15514116]
comment: An example of this is mouse ferroportin (UniProt symbol Q9JHI9), which transports iron out of the cell.
synonym: "iron cation channel activity" EXACT []
is_a: GO:0005261 ! cation channel activity
is_a: GO:0005381 ! iron ion transmembrane transporter activity
relationship: part_of GO:0034755 ! iron ion transmembrane transport

[Term]
id: GO:0097690
name: iron channel inhibitor activity
namespace: molecular_function
def: "Stops, prevents, or reduces the activity of an iron channel." [GOC:BHF, GOC:kom, PMID:15514116]
comment: An example of this is human hepcidin (UniProt symbol P81172), which regulates iron transport out of cells (see PMID:15514116).
is_a: GO:0008200 ! ion channel inhibitor activity
relationship: negatively_regulates GO:0097689 ! iron channel activity

[Term]
id: GO:0097691
name: bacterial extracellular vesicle
namespace: cellular_component
def: "Small membrane vesicle (< 1 um) that buds off a prokaryotic cell plasma membrane, able to carry proteins, phospholipids, lipopolysaccharides, nucleic acids, viruses, and more. Important in intercellular communication and pathogenesis; can exist within host cells." [GOC:aa, PMID:25704309]
is_a: GO:1903561 ! extracellular vesicle
created_by: paola
creation_date: 2015-09-24T11:31:44Z

[Term]
id: GO:0097692
name: histone H3-K4 monomethylation
namespace: biological_process
def: "The modification of histone H3 by addition of one methyl group to lysine at position 4 of the histone." [GOC:jh2, PMID:26320581]
is_a: GO:0051568 ! histone H3-K4 methylation
created_by: paola
creation_date: 2015-11-05T11:23:15Z

[Term]
id: GO:0097693
name: ocelloid
namespace: cellular_component
def: "Eye-like subcellular structure found in dinoflagellates (a large group of single-celled eukaryotes). Consists of subcellular analogues to a cornea, lens, iris, and retina. Ocelloids are built from pre-existing organelles, including a cornea-like layer made of mitochondria and a retinal body made of anastomosing plastids." [GOC:ar, PMID:26131935]
is_a: GO:0043229 ! intracellular organelle
relationship: has_part GO:0005739 ! mitochondrion
relationship: has_part GO:0009536 ! plastid
created_by: paola
creation_date: 2015-11-13T14:27:01Z

[Term]
id: GO:0097694
name: establishment of RNA localization to telomere
namespace: biological_process
def: "The directed movement of RNA to a specific location in the telomeric region of a chromosome." [GOC:BHF, GOC:BHF_telomere, GOC:rph, PMID:26586433]
synonym: "establishment of RNA localisation to telomere" EXACT []
is_a: GO:0051236 ! establishment of RNA localization
created_by: paola
creation_date: 2015-12-22T09:33:43Z

[Term]
id: GO:0097695
name: establishment of macromolecular complex localization to telomere
namespace: biological_process
def: "The directed movement of a macromolecular complex to a specific location in the telomeric region of a chromosome." [GOC:BHF, GOC:BHF_telomere, GOC:rph, PMID:26586433]
synonym: "establishment of macromolecular complex localisation to telomere" EXACT []
is_a: GO:0051234 ! establishment of localization
relationship: part_of GO:0070727 ! cellular macromolecule localization
created_by: paola
creation_date: 2015-12-22T09:38:13Z

[Term]
id: GO:0097696
name: STAT cascade
namespace: biological_process
def: "An intracellular signal transduction process in which STAT proteins (Signal Transducers and Activators of Transcription) convey a signal to trigger a change in the activity or state of a cell. The STAT cascade begins with activation of STAT proteins by kinases, proceeds through dimerization and subsequent nuclear translocation of STAT proteins, and ends with regulation of target gene expression by STAT proteins." [GOC:rjd, PMID:21534947, PMID:24587195]
comment: In most species, STAT proteins are activated by members of the JAK (Janus Activated Kinase) family of tyrosine kinases; the term GO:0007259 'JAK-STAT cascade' describes this specificity. In other cases, such as D. discoideum, no JAK orthologs are known, and STAT proteins are activated by tyrosine kinase-like proteins.
synonym: "kinase activated-STAT cascade" EXACT []
synonym: "kinase-STAT cascade" EXACT []
synonym: "STAT signalling pathway" EXACT []
is_a: GO:0035556 ! intracellular signal transduction
created_by: paola
creation_date: 2015-12-22T10:40:14Z

[Term]
id: GO:0097697
name: tRNA 5-carboxymethoxyuridine methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosylmethionine to a 5-carboxymethoxy-modified uridine residue in a tRNA molecule." [GOC:imk, PMID:26681692]
is_a: GO:0016300 ! tRNA (uracil) methyltransferase activity
created_by: paola
creation_date: 2016-01-07T10:36:46Z

[Term]
id: GO:0097698
name: telomere maintenance via base-excision repair
namespace: biological_process
def: "A telomere maintenance process that occurs by base-excision repair of telomeric DNA in response to DNA damage. Telomeric sequences are particularly susceptible to oxidative DNA damage, due to their G-rich nature." [GOC:BHF, GOC:BHF_telomere, GOC:jbu, PMID:24703901]
is_a: GO:0006284 ! base-excision repair
is_a: GO:0043247 ! telomere maintenance in response to DNA damage
created_by: paola
creation_date: 2016-01-07T11:15:39Z

[Term]
id: GO:0097699
name: vascular endothelial cell response to fluid shear stress
namespace: biological_process
def: "Any response to fluid shear stress in a vascular endothelial cell." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:21768538]
synonym: "blood vessel endothelial cell response to fluid shear stress" EXACT []
is_a: GO:0071498 ! cellular response to fluid shear stress
created_by: paola
creation_date: 2016-01-27T12:37:32Z

[Term]
id: GO:0097700
name: vascular endothelial cell response to laminar fluid shear stress
namespace: biological_process
def: "Any response to laminar fluid shear stress in a vascular endothelial cell." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:21768538]
synonym: "blood vessel endothelial cell response to laminar fluid shear stress" EXACT []
is_a: GO:0071499 ! cellular response to laminar fluid shear stress
is_a: GO:0097699 ! vascular endothelial cell response to fluid shear stress
created_by: paola
creation_date: 2016-01-27T12:42:01Z

[Term]
id: GO:0097701
name: response to pulsatile fluid shear stress
namespace: biological_process
def: "Any response to fluid shear stress where the fluid is flowing across a solid surface with periodic variations. For example, the endothelium in straight parts of the artery tree is subjected to pulsatile shear stress with a significant forward direction, which is believed to be an important physiological stimulus enhancing vessel compliance and conferring anti-thrombotic, anti-adhesive, and anti-inflammatory effects." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:21768538]
is_a: GO:0034405 ! response to fluid shear stress
created_by: paola
creation_date: 2016-01-27T14:13:31Z

[Term]
id: GO:0097702
name: response to oscillatory fluid shear stress
namespace: biological_process
def: "Any response to fluid shear stress where the fluid is moving across a solid surface with an oscillatory flow. Disturbed flow patterns at the arterial bifurcations and curvatures may cause endothelial dysfunction, which initiates atherosclerosis." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:21768538]
is_a: GO:0034405 ! response to fluid shear stress
created_by: paola
creation_date: 2016-01-27T14:17:08Z

[Term]
id: GO:0097703
name: cellular response to pulsatile fluid shear stress
namespace: biological_process
def: "Any response to pulsatile fluid shear stress that occurs at the level of a cell." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:21768538]
is_a: GO:0071498 ! cellular response to fluid shear stress
is_a: GO:0097701 ! response to pulsatile fluid shear stress
created_by: paola
creation_date: 2016-01-27T14:18:23Z

[Term]
id: GO:0097704
name: cellular response to oscillatory fluid shear stress
namespace: biological_process
def: "Any response to oscillatory fluid shear stress that occurs at the level of a cell." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:21768538]
is_a: GO:0071498 ! cellular response to fluid shear stress
is_a: GO:0097702 ! response to oscillatory fluid shear stress
created_by: paola
creation_date: 2016-01-27T14:20:54Z

[Term]
id: GO:0097705
name: vascular endothelial cell response to pulsatile fluid shear stress
namespace: biological_process
def: "Any response to pulsatile fluid shear stress that occurs in a vascular endothelial cell." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:21768538]
synonym: "blood vessel endothelial cell response to pulsatile fluid shear stress" EXACT []
is_a: GO:0097699 ! vascular endothelial cell response to fluid shear stress
is_a: GO:0097703 ! cellular response to pulsatile fluid shear stress
created_by: paola
creation_date: 2016-01-27T14:22:44Z

[Term]
id: GO:0097706
name: vascular endothelial cell response to oscillatory fluid shear stress
namespace: biological_process
def: "Any response to oscillatory fluid shear stress that occurs in a vascular endothelial cell." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:21768538]
synonym: "blood vessel endothelial cell response to oscillatory fluid shear stress" EXACT []
is_a: GO:0097699 ! vascular endothelial cell response to fluid shear stress
is_a: GO:0097704 ! cellular response to oscillatory fluid shear stress
created_by: paola
creation_date: 2016-01-27T14:25:34Z

[Term]
id: GO:0097707
name: ferroptosis
namespace: biological_process
def: "A programmed cell death characterized morphologically by the presence of smaller than normal mitochondria with condensed mitochondrial membrane densities, reduction or vanishing of mitochondria crista, and outer mitochondrial membrane rupture. Activation of mitochondrial voltage-dependent anion channels and mitogen-activated protein kinases, upregulation of endoplasmic reticulum stress, and inhibition of cystine/glutamate antiporter are involved in the induction of ferroptosis. This process is characterized by the accumulation of lipid peroxidation products and lethal reactive oxygen species (ROS) derived from iron metabolism. Glutathione peroxidase 4 (GPX4), heat shock protein beta-1, and nuclear factor erythroid 2-related factor 2 function as negative regulators of ferroptosis by limiting ROS production and reducing cellular iron uptake, respectively. In contrast, NADPH oxidase and p53 act as positive regulators of ferroptosis by promotion of ROS production and inhibition of expression of SLC7A11 (a specific light-chain subunit of the cystine/glutamate antiporter), respectively. Misregulated ferroptosis has been implicated in multiple physiological and pathological processes." [GOC:mtg_apoptosis, PMID:25236395, PMID:26794443]
synonym: "iron-dependent programmed cell death" RELATED []
is_a: GO:0012501 ! programmed cell death
created_by: paola
creation_date: 2016-03-03T12:51:18Z

[Term]
id: GO:0097708
name: intracellular vesicle
namespace: cellular_component
def: "Any vesicle that is part of the intracellular region." [GOC:vesicles]
is_a: GO:0031982 ! vesicle
is_a: GO:0044424 ! intracellular part
intersection_of: GO:0031982 ! vesicle
intersection_of: part_of GO:0005622 ! intracellular
relationship: part_of GO:0005622 ! intracellular
created_by: paola
creation_date: 2016-03-29T17:39:45Z

[Term]
id: GO:0098001
name: receptor-mediated bacteriophage reversible attachment to host cell
namespace: biological_process
def: "Process by which a bacteriophage, using its tail fibers, spikes or a baseplate component, initially recognizes and binds to its specific receptor on the host cell surface. This process is reversible and allows the release of a bacteriophage without affecting infection." [GOC:bm, phi:0000005]
comment: This process was historically defined by the release, by Waring blending or sonication, by dilution and centrifugation, or by filtration and washing, of infective virions from their complexes with cells, thus contrary to what is observed after irreversible adsorption.
synonym: "phage reversible adsorption" RELATED [GOC:bm]
synonym: "reversible bacteriophage attachment, binding of host cell surface receptor" EXACT [GOC:bf, GOC:jl]
is_a: GO:0046813 ! receptor-mediated virion attachment to host cell
created_by: brenley

[Term]
id: GO:0098002
name: receptor-mediated bacteriophage irreversible attachment to host cell
namespace: biological_process
def: "The processes by which a bacteriophage initially commits to infection by binding the host receptor irreversibly. Disruption of the phage:cell complex at this step results in the loss of infective phage virions since the process is characterized by conformational changes of bacteriophage head and tail proteins and injection of bacteriophage proteins into the infected cell." [GOC:bm, phi:0000006]
synonym: "irreversible bacteriophage attachment, binding of host cell surface receptor" EXACT [GOC:bf, GOC:jl]
synonym: "phage irreversible adsorption" RELATED [GOC:bm]
is_a: GO:0046813 ! receptor-mediated virion attachment to host cell
created_by: brenley

[Term]
id: GO:0098003
name: viral tail assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a virus tail." [GOC:bm, PHI:0000015]
subset: virus_checked
synonym: "bacteriophage tail assembly" NARROW [GOC:bm]
synonym: "virus tail assembly" EXACT [GOC:bf, GOC:jl]
is_a: GO:0016032 ! viral process
is_a: GO:0022607 ! cellular component assembly
relationship: part_of GO:0019068 ! virion assembly
created_by: brenley
creation_date: 2012-07-18T16:01:59Z

[Term]
id: GO:0098004
name: virus tail fiber assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a virus tail fiber." [GOC:bm, PHI:0000011]
subset: virus_checked
is_a: GO:0016032 ! viral process
is_a: GO:0022607 ! cellular component assembly
relationship: part_of GO:0098003 ! viral tail assembly
created_by: brenley
creation_date: 2012-07-18T16:08:15Z

[Term]
id: GO:0098005
name: viral head-tail joining
namespace: biological_process
def: "Process by which virus heads and tails are attached to each other." [GOC:bm, PHI:0000012]
subset: virus_checked
synonym: "phage head tail joining" NARROW [GOC:bm]
synonym: "virus head-tail joining" EXACT [GOC:bf, GOC:jl]
is_a: GO:0016032 ! viral process
relationship: part_of GO:0019068 ! virion assembly
created_by: brenley
creation_date: 2012-07-18T16:11:59Z

[Term]
id: GO:0098006
name: viral DNA genome packaging, headful
namespace: biological_process
def: "The encapsulation of the viral genome within the capsid where DNA is packaged into the capsid until the capsid is full." [GOC:bm, PHI:0000020]
comment: Generalized transducing phages usually use this mode of DNA packaging.
subset: virus_checked
synonym: "phage headful packaging" NARROW [GOC:bm]
is_a: GO:0019073 ! viral DNA genome packaging
created_by: brenley
creation_date: 2012-07-18T16:15:09Z

[Term]
id: GO:0098009
name: virus terminase, large subunit
namespace: cellular_component
def: "The part of the viral terminase complex that contains the translocase activity. The large subunit typically comprises a pentameric protein complex." [GOC:bm, PHI:0000073]
comment: This term should only be used when the large subunit consists of more than one polypeptide.
subset: virus_checked
is_a: GO:0043234 ! protein complex
is_a: GO:0044423 ! virion part
relationship: part_of GO:0043493 ! viral terminase complex
created_by: brenley
creation_date: 2012-07-25T10:13:00Z

[Term]
id: GO:0098015
name: virus tail
namespace: cellular_component
def: "Part of the virion that may be used to recognize, attach and inject the viral genome and accessory proteins into the host cell." [GOC:bm, PHI:0000174]
comment: Many bacteriophages with dsDNA genomes, or Caudovirales, have a tail. The viral tail can be short (Podoviridae), long and non-contractile (Siphoviridae) or long and contractile (Myoviridae). The tail is the channel through which the phage genome is injected into the host bacterial cell.
subset: virus_checked
synonym: "bacteriophage tail" NARROW [GOC:bm]
synonym: "viral tail" RELATED [GOC:bf]
is_a: GO:0044423 ! virion part
created_by: brenley
creation_date: 2012-07-18T17:04:46Z

[Term]
id: GO:0098017
name: viral capsid, major subunit
namespace: cellular_component
def: "The part of the viral capsid that comprises the most common capsomere type. For example, in a T=3 icosahedral capsid, which is composed of 12 pentameric and 20 hexameric capsomeres, the hexameric capsomeres are major subunits." [GOC:bm, PHI:0000066]
synonym: "major capsomere" EXACT [GOC:bf, GOC:bm, GOC:jl]
synonym: "major head protein" RELATED [PHI:0000066]
is_a: GO:0046727 ! capsomere
created_by: brenley
creation_date: 2012-07-19T11:21:21Z

[Term]
id: GO:0098018
name: viral capsid, minor subunit
namespace: cellular_component
def: "The part of the viral capsid that comprises the less common capsomere type. For example, in a T=3 icosahedral capsid, which is composed of 12 pentameric and 20 hexameric capsomeres, the pentameric capsomeres are minor subunits." [GOC:bm, PHI:00000185]
subset: virus_checked
synonym: "minor capsomere" EXACT [GOC:bf, GOC:bm, GOC:jl]
synonym: "minor head protein" RELATED [PHI:0000185]
is_a: GO:0046727 ! capsomere
created_by: brenley
creation_date: 2012-07-19T11:28:18Z

[Term]
id: GO:0098019
name: virus tail, major subunit
namespace: cellular_component
def: "The part of the viral tail that comprises the most common subunit type." [GOC:bm, PHI:0000082]
comment: Particularly used to describe the major subunits of the tailed bacteriophage types Myoviridae and Siphoviridae.
subset: virus_checked
synonym: "major tail protein" RELATED [PHI:0000082]
is_a: GO:0044423 ! virion part
relationship: part_of GO:0098015 ! virus tail
created_by: brenley
creation_date: 2012-07-19T11:32:55Z

[Term]
id: GO:0098020
name: virus tail, minor subunit
namespace: cellular_component
def: "The part of the viral tail that comprises the least common subunit type." [GOC:bm, PHI:0000178]
comment: Particularly used to describe the minor subunits of the tailed bacteriophage types Myoviridae and Siphoviridae.
subset: virus_checked
synonym: "bacteriophage minor protein subunit" NARROW [GOC:bm]
synonym: "minor tail protein" RELATED [GOC:bm]
is_a: GO:0044423 ! virion part
relationship: part_of GO:0098015 ! virus tail
created_by: brenley
creation_date: 2012-07-19T11:36:25Z

[Term]
id: GO:0098021
name: viral capsid, decoration
namespace: cellular_component
def: "Component of the virus capsid (head), located on the outer head surface. Involved in the stabilization of the head structure and usually non-essential." [GOC:bm, PHI:0000069]
subset: virus_checked
synonym: "decoration protein" RELATED [GOC:bm]
is_a: GO:0044423 ! virion part
relationship: part_of GO:0019028 ! viral capsid
created_by: brenley
creation_date: 2012-07-19T11:52:53Z

[Term]
id: GO:0098022
name: viral capsid, fiber
namespace: cellular_component
def: "A type of capsid decoration composed of fiber structures." [GOC:bm, PHI:0000070, PHI:0000176]
subset: virus_checked
synonym: "head/capsid fiber" RELATED [GOC:bm]
xref: PHI:0000070 "phage head/capsid fiber protein"
xref: PHI:0000176 "phage head/capsid fiber"
is_a: GO:0098021 ! viral capsid, decoration
created_by: brenley
creation_date: 2012-07-19T11:56:32Z

[Term]
id: GO:0098023
name: virus tail, tip
namespace: cellular_component
def: "The basal end of the virus tail, which is used by the virus to attach to the host cell." [GOC:bm, PHI:0000087]
subset: virus_checked
synonym: "bacteriophage tail tip" NARROW [GOC:bm]
is_a: GO:0044423 ! virion part
relationship: part_of GO:0098015 ! virus tail
created_by: brenley
creation_date: 2012-07-19T14:13:02Z

[Term]
id: GO:0098024
name: virus tail, fiber
namespace: cellular_component
def: "The fibrous region of the virus tail used to scan, recognize and attach to the host cell." [GOC:bm, PHI:0000024, PHI:0000175]
comment: For tailed bacteriophages, fibers typically bind to particular Lipopolysaccharide (LPS), polysaccharide or protein receptors on the cell surface.
subset: virus_checked
synonym: "bacteriophage tail fiber" NARROW [GOC:bm]
is_a: GO:0044423 ! virion part
relationship: part_of GO:0098015 ! virus tail
created_by: brenley
creation_date: 2012-07-19T14:14:50Z

[Term]
id: GO:0098025
name: virus tail, baseplate
namespace: cellular_component
def: "Multiprotein component at the distal (head) end of the virus tail to which fibers of tailed viruses may be attached." [GOC:bm, PHI:0000088]
comment: Tail fibers are often attached to the baseplate of Caudovirales (tailed bacteriophages with dsDNA genomes). Sometimes referred to as the tail tip or tip structure in Siphoviridae.
subset: virus_checked
synonym: "bacteriophage baseplate" NARROW [GOC:bm]
synonym: "tail structure" RELATED [GOC:bm]
synonym: "tail tip" RELATED [GOC:bm]
is_a: GO:0044423 ! virion part
relationship: part_of GO:0098015 ! virus tail
created_by: brenley
creation_date: 2012-07-19T14:16:51Z

[Term]
id: GO:0098026
name: virus tail, tube
namespace: cellular_component
def: "The internal tube of the contractile tails of some viruses. The virus tail tube is the channel for DNA ejection into the host cytoplasm." [GOC:bm, PHI:0000026]
comment: Applies in particular the Myoviridae bacteriophages.
subset: virus_checked
synonym: "bacteriophage tail tube" NARROW [GOC:bm]
is_a: GO:0044423 ! virion part
relationship: part_of GO:0098015 ! virus tail
created_by: brenley
creation_date: 2012-07-19T14:21:28Z

[Term]
id: GO:0098027
name: virus tail, sheath
namespace: cellular_component
def: "The external contractile envelope of the tail of some viruses. Its contraction ensures ejection of the virus DNA into the host cytoplasm." [GOC:bm, PHI:0000084]
subset: virus_checked
synonym: "bacteriophage tail sheath" NARROW [GOC:bm]
is_a: GO:0044423 ! virion part
relationship: part_of GO:0098015 ! virus tail
created_by: brenley
creation_date: 2012-07-19T14:23:27Z

[Term]
id: GO:0098028
name: virus tail, shaft
namespace: cellular_component
def: "The tube of the non-contractile tails of some viruses." [GOC:bm, PHI:0000085]
comment: This term applies in particular to the Siphoviridae bacteriophages, where the shaft is the channel for DNA translocation into the host cytoplasm.
subset: virus_checked
synonym: "bacteriophage tail shaft" NARROW [GOC:bm]
is_a: GO:0044423 ! virion part
relationship: part_of GO:0098015 ! virus tail
created_by: brenley
creation_date: 2012-07-19T14:24:28Z

[Term]
id: GO:0098029
name: icosahedral viral capsid, spike
namespace: cellular_component
def: "A short structure attached to an icosahedral virion capsid, and used for attachment to the host cell." [GOC:bm, PHI:0000208]
subset: virus_checked
is_a: GO:0044423 ! virion part
relationship: part_of GO:0019030 ! icosahedral viral capsid
created_by: brenley
creation_date: 2012-07-19T14:37:11Z

[Term]
id: GO:0098030
name: icosahedral viral capsid, neck
namespace: cellular_component
def: "A region of constriction located below the head and above the tail sheath of viruses with contractile tails (Myoviridae)." [GOC:bm, PHI:0000205, PHI:0000309]
subset: virus_checked
is_a: GO:0044423 ! virion part
relationship: part_of GO:0019030 ! icosahedral viral capsid
created_by: brenley
creation_date: 2012-07-19T14:56:28Z

[Term]
id: GO:0098031
name: icosahedral viral capsid, collar
namespace: cellular_component
def: "A small disk located at the base of some icosahedral virus capsids." [GOC:bm, PHI:0000206, PHI:0000308]
subset: virus_checked
is_a: GO:0044423 ! virion part
relationship: part_of GO:0019030 ! icosahedral viral capsid
created_by: brenley
creation_date: 2012-07-19T15:01:12Z

[Term]
id: GO:0098032
name: icosahedral viral capsid, collar fiber
namespace: cellular_component
def: "A fiber attached to the collar structure of some icosahedral viral capsids." [GOC:bm, PHI:0000207, PHI:0000307]
subset: virus_checked
is_a: GO:0044423 ! virion part
relationship: part_of GO:0098031 ! icosahedral viral capsid, collar
created_by: brenley
creation_date: 2012-07-19T15:05:16Z

[Term]
id: GO:0098033
name: icosahedral viral capsid, neck fiber
namespace: cellular_component
def: "A fiber attached to the neck at the base of some icosahedral viral capsids." [GOC:bm, PHI:0000075, PHI:0000310]
subset: virus_checked
is_a: GO:0044423 ! virion part
relationship: part_of GO:0098030 ! icosahedral viral capsid, neck
created_by: brenley
creation_date: 2012-07-19T15:07:39Z

[Term]
id: GO:0098035
name: viral DNA genome packaging via site-specific sequence recognition
namespace: biological_process
def: "The encapsulation of the viral DNA genome within the capsid, which proceeds via cleavage of the viral DNA at specific sites by a viral terminase." [GOC:bm]
subset: virus_checked
is_a: GO:0019073 ! viral DNA genome packaging
relationship: has_part GO:0019071 ! viral DNA cleavage involved in viral genome maturation
created_by: brenley
creation_date: 2012-07-20T11:36:49Z

[Term]
id: GO:0098036
name: viral DNA genome packaging, 3' extended cos packaging
namespace: biological_process
def: "The encapsulation of the viral DNA genome within the capsid, which proceeds via cleavage of the viral DNA at specific sites to produce 3' protruding ends." [GOC:bm, PHI:0000021]
subset: virus_checked
is_a: GO:0098035 ! viral DNA genome packaging via site-specific sequence recognition
created_by: brenley
creation_date: 2012-07-20T11:38:40Z

[Term]
id: GO:0098037
name: viral DNA genome packaging, 5' extended cos packaging
namespace: biological_process
def: "The encapsulation of the viral DNA genome within the capsid, which proceeds via cleavage of the viral DNA at specific sites to produce 5' protruding ends." [GOC:bm, PHI:0000022]
subset: virus_checked
is_a: GO:0098035 ! viral DNA genome packaging via site-specific sequence recognition
created_by: brenley
creation_date: 2012-07-20T11:40:47Z

[Term]
id: GO:0098038
name: non-replicative transposition, DNA-mediated
namespace: biological_process
def: "Process by which a transposable element is excised from the donor site and integrated at the target site without replication of the element. Also referred to as cut-and-paste transposition." [GOC:bm, PHI:0000137, PMID:2553270]
subset: virus_checked
synonym: "cut-and-paste transposition" EXACT [GOC:bm]
is_a: GO:0006313 ! transposition, DNA-mediated
created_by: brenley
creation_date: 2012-07-20T16:47:50Z

[Term]
id: GO:0098039
name: replicative transposition, DNA-mediated
namespace: biological_process
def: "Process of transposition in which the existing element is replicated and one of the copies is excised and integrated at a new target site. Also referred to as copy-and-paste transposition." [GOC:bm, PMID:10540284]
subset: virus_checked
synonym: "copy-and-paste transposition" EXACT [GOC:bm]
synonym: "transpositional DNA genome replication" EXACT [PHI:0000037]
is_a: GO:0006313 ! transposition, DNA-mediated
relationship: has_part GO:0006260 ! DNA replication
created_by: brenley
creation_date: 2012-07-20T16:52:02Z

[Term]
id: GO:0098045
name: virus baseplate assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a virus baseplate." [GOC:bm, PHI:0000328]
subset: virus_checked
is_a: GO:0016032 ! viral process
is_a: GO:0022607 ! cellular component assembly
relationship: part_of GO:0098003 ! viral tail assembly
created_by: brenley
creation_date: 2012-07-25T14:50:32Z

[Term]
id: GO:0098046
name: type V protein secretion system complex
namespace: cellular_component
def: "A complex of proteins that permits the translocation of proteins across the outer membrane via a transmembrane pore, formed by a beta-barrel, into the extracellular milieu or directly into host cells; the secreted proteins contain all the information required for translocation of an effector molecule through the cell envelope. The type V secretion systems includes the autotransporters (type Va), the two-partner secretion system (type Vb) and the Oca family (type Vc)." [GOC:bf, GOC:bm, PMID:15119822, PMID:15590781]
comment: Note that the type II protein secretion system complex does not include components of the Sec or Tat pathways. For components of these pathways, consider annotating to 'cell envelope Sec complex ; GO:0031522' or 'TAT protein translocation system complex ; GO:0033281'.
subset: virus_checked
synonym: "autotransporter system complex" NARROW [PMID:15590781, Wikipedia:Secretion]
synonym: "T5SS complex" EXACT [Wikipedia:Secretion]
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
created_by: rfoulger
creation_date: 2012-08-01T10:05:49Z

[Term]
id: GO:0098061
name: viral capsid, internal space
namespace: cellular_component
def: "The region of a virus contained within the capsid shell, and usually containing the viral genome and accessory proteins." [GOC:bm]
synonym: "internal head protein" EXACT [GOC:bm]
is_a: GO:0044423 ! virion part
created_by: brenley
creation_date: 2012-08-01T12:12:47Z

[Term]
id: GO:0098501
name: polynucleotide dephosphorylation
namespace: biological_process
def: "The process of removing one or more phosphate groups from a polynucleotide." [GOC:DOS]
is_a: GO:0006139 ! nucleobase-containing compound metabolic process
is_a: GO:0016311 ! dephosphorylation
is_a: GO:0043170 ! macromolecule metabolic process
created_by: davidos
creation_date: 2013-09-18T14:49:10Z

[Term]
id: GO:0098502
name: DNA dephosphorylation
namespace: biological_process
def: "The process of removing one or more phosphate groups from a DNA molecule." [GOC:DOS]
is_a: GO:0006259 ! DNA metabolic process
is_a: GO:0098501 ! polynucleotide dephosphorylation
created_by: davidos
creation_date: 2013-09-18T14:50:16Z

[Term]
id: GO:0098503
name: DNA 3' dephosphorylation
namespace: biological_process
def: "The process of removing a 3' phosphate group from a DNA molecule." [GOC:DOS]
is_a: GO:0098502 ! DNA dephosphorylation
created_by: davidos
creation_date: 2013-09-18T14:51:17Z

[Term]
id: GO:0098504
name: DNA 3' dephosphorylation involved in DNA repair
namespace: biological_process
def: "Any 3' DNA dephosphorylation that is involved in the process of DNA repair." [GOC:DOS, PMID:11729194]
is_a: GO:0098503 ! DNA 3' dephosphorylation
intersection_of: GO:0098503 ! DNA 3' dephosphorylation
intersection_of: part_of GO:0006281 ! DNA repair
relationship: part_of GO:0006281 ! DNA repair
created_by: davidos
creation_date: 2013-09-18T14:52:15Z

[Term]
id: GO:0098505
name: G-rich strand telomeric DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with G-rich, single-stranded, telomere-associated DNA." [PMID:11349150]
is_a: GO:0043047 ! single-stranded telomeric DNA binding
created_by: davidos
creation_date: 2013-09-23T13:16:24Z

[Term]
id: GO:0098506
name: polynucleotide 3' dephosphorylation
namespace: biological_process
def: "The process of removing one or more phosphate groups from the 3' end of a polynucleotide." [GOC:dos]
is_a: GO:0098501 ! polynucleotide dephosphorylation

[Term]
id: GO:0098507
name: polynucleotide 5' dephosphorylation
namespace: biological_process
def: "The process of removing one or more phosphate groups from the 5' end of a polynucleotide." [GOC:dos]
is_a: GO:0098501 ! polynucleotide dephosphorylation

[Term]
id: GO:0098508
name: endothelial to hematopoietic transition
namespace: biological_process
def: "The generation of hematopoietic stem cells from hemogenic endothelial cells by a process that includes tight-junction dissolution and loss of cell polarity followed by delamination from the endothelium." [PMID:20154732, PMID:22521721]
is_a: GO:0000904 ! cell morphogenesis involved in differentiation
is_a: GO:0060232 ! delamination
created_by: davidos
creation_date: 2013-09-24T15:20:39Z

[Term]
id: GO:0098509
name: sensory perception of humidity
namespace: biological_process
def: "The series of events required for an organism to detect some level of humidity in its environment, convert this detection into a molecular signal, and recognize and characterize the signal. This is a neurological process." [PMID:18269908, PMID:8650222]
comment: Note, this is not classified under 'detection of chemical stimulus' as there are various potential mechanisms of hygroperception including detection of mechanical stimulus.
synonym: "hygrosensory perception" EXACT [PMID:8650222]
is_a: GO:0007600 ! sensory perception
created_by: davidos
creation_date: 2013-09-25T13:52:27Z

[Term]
id: GO:0098510
name: sensory perception of high humidity
namespace: biological_process
def: "The series of events required for an organism to detect high environmental humidity, convert this detection into a molecular signal, and recognize and characterize the signal. This is a neurological process." [PMID:18269908]
is_a: GO:0098509 ! sensory perception of humidity
created_by: davidos
creation_date: 2013-09-25T13:57:27Z

[Term]
id: GO:0098511
name: sensory perception of low humidity
namespace: biological_process
def: "The series of events required for an organism to detect low environmental humidity, convert this detection into a molecular signal, and recognize and characterize the signal. This is a neurological process." [PMID:18269908]
is_a: GO:0098509 ! sensory perception of humidity
created_by: davidos
creation_date: 2013-09-25T14:02:02Z

[Term]
id: GO:0098512
name: detection of humidity stimulus involved in sensory perception
namespace: biological_process
def: "The series of events in which a humidity stimulus is received and converted into a molecular signal as part of the sensory perception of humidity." [GOC:dos, PMID:8650222]
is_a: GO:0050906 ! detection of stimulus involved in sensory perception
is_a: GO:0098513 ! detection of humidity
intersection_of: GO:0098513 ! detection of humidity
intersection_of: part_of GO:0098509 ! sensory perception of humidity
relationship: part_of GO:0098509 ! sensory perception of humidity
created_by: davidos
creation_date: 2013-09-25T14:09:25Z

[Term]
id: GO:0098513
name: detection of humidity
namespace: biological_process
def: "The series of events in which a humidity stimulus is received and converted into a molecular signal." [GOC:dos]
is_a: GO:0009581 ! detection of external stimulus
is_a: GO:0009582 ! detection of abiotic stimulus
created_by: davidos
creation_date: 2013-09-25T14:11:13Z

[Term]
id: GO:0098514
name: detection of high humidity stimulus involved in sensory perception
namespace: biological_process
def: "The series of events in which a high humidity stimulus is detected and converted into a molecular signal as a part of the sensory detection of high humidity." [GOC:dos, PMID:18269908]
is_a: GO:0098512 ! detection of humidity stimulus involved in sensory perception
is_a: GO:0098516 ! detection of high humidity
intersection_of: GO:0098516 ! detection of high humidity
intersection_of: part_of GO:0098510 ! sensory perception of high humidity
relationship: part_of GO:0098510 ! sensory perception of high humidity
created_by: davidos
creation_date: 2013-09-25T14:20:54Z

[Term]
id: GO:0098515
name: detection of low humidity stimulus involved in sensory perception
namespace: biological_process
def: "The series of events in which a low humidity stimulus is detected and converted into a molecular signal as a part of the sensory detection of low humidity." [GOC:dos, PMID:18269908]
is_a: GO:0098512 ! detection of humidity stimulus involved in sensory perception
is_a: GO:0098517 ! detection of low humidity
intersection_of: GO:0098517 ! detection of low humidity
intersection_of: part_of GO:0098511 ! sensory perception of low humidity
relationship: part_of GO:0098511 ! sensory perception of low humidity
created_by: davidos
creation_date: 2013-09-25T14:24:29Z

[Term]
id: GO:0098516
name: detection of high humidity
namespace: biological_process
def: "The series of events in which high humidity is detected and converted into a molecular signal." [GOC:dos]
is_a: GO:0098513 ! detection of humidity
created_by: davidos
creation_date: 2013-09-25T14:26:47Z

[Term]
id: GO:0098517
name: detection of low humidity
namespace: biological_process
def: "The series of events in which low humidity is detected and converted into a molecular signal." [GOC:dos]
is_a: GO:0098513 ! detection of humidity
created_by: davidos
creation_date: 2013-09-25T14:27:18Z

[Term]
id: GO:0098518
name: polynucleotide phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphopolynucleotide + H2O = polynucleotide + phosphate." [GOC:mah]
is_a: GO:0016791 ! phosphatase activity
relationship: part_of GO:0098501 ! polynucleotide dephosphorylation
created_by: davidos
creation_date: 2013-09-26T11:02:35Z

[Term]
id: GO:0098519
name: nucleotide phosphatase activity, acting on free nucleotides
namespace: molecular_function
def: "Catalysis of the reaction: nucleotide + H2O = nucleotide + phosphate." [GOC:dos]
comment: To be used for NTP->NDP or NDP -> NMP. For nucleotide -> nucleoside (all phosphates removed) use nucleotidase.
synonym: "nucleotide phosphatase activity" EXACT []
is_a: GO:0016791 ! phosphatase activity
created_by: davidos
creation_date: 2013-09-26T11:04:45Z

[Term]
id: GO:0098520
name: excitatory neuromuscular junction
namespace: cellular_component
def: "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a post-synaptic potential responsible for muscle contraction." [GOC:dos]
is_a: GO:0031594 ! neuromuscular junction
is_a: GO:0060076 ! excitatory synapse
created_by: davidos
creation_date: 2013-10-14T12:02:51Z

[Term]
id: GO:0098521
name: inhibitory neuromuscular junction
namespace: cellular_component
def: "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential that inhibits muscle contraction." [GOC:dos]
is_a: GO:0031594 ! neuromuscular junction
is_a: GO:0060077 ! inhibitory synapse
created_by: davidos
creation_date: 2013-10-14T12:04:08Z

[Term]
id: GO:0098522
name: neuromuscular junction of skeletal muscle fiber
namespace: cellular_component
def: "A neuromuscular junction in which the target muscle cell is a skeletal muscle fiber." [GOC:dos]
comment: In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting skeletal muscle fibers - all of which are  cholinergic and excitatory.  Both inhibitory and excitatory neuromuscular junctions exist in invertebrates, utilizing a range of neurotransmitters including glutamate, GABA and 5-HT.
is_a: GO:0098520 ! excitatory neuromuscular junction
is_a: GO:0098523 ! neuromuscular junction of myotube
created_by: davidos
creation_date: 2013-10-14T12:04:32Z

[Term]
id: GO:0098523
name: neuromuscular junction of myotube
namespace: cellular_component
def: "A neuromuscular junction in which the target muscle cell is a myotube." [GOC:dos]
comment: In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting the myotubes of skeletal muscle (AKA skeletal muscle fibers). Neuromuscular junctions targeting other muscle cell types exist in invertebrates such as the mononucleate somatic muscles of nematodes.
is_a: GO:0031594 ! neuromuscular junction
created_by: davidos
creation_date: 2013-10-14T12:05:12Z

[Term]
id: GO:0098524
name: neuromuscular junction of somatic muscle myotube
namespace: cellular_component
def: "A neuromuscular junction in which the target muscle cell is a somatic muscle myotube, such as an arthropod somatic muscle cell." [GOC:dos]
is_a: GO:0098523 ! neuromuscular junction of myotube
is_a: GO:0098527 ! neuromuscular junction of somatic muscle
created_by: davidos
creation_date: 2013-10-14T12:05:43Z

[Term]
id: GO:0098525
name: excitatory neuromuscular junction of somatic myotube
namespace: cellular_component
def: "A neuromuscular junction that functions in the excitation of somatic muscle myotubes, such as an arthropod somatic muscle cells." [GOC:dos]
is_a: GO:0098520 ! excitatory neuromuscular junction
is_a: GO:0098524 ! neuromuscular junction of somatic muscle myotube
created_by: davidos
creation_date: 2013-10-14T12:06:08Z

[Term]
id: GO:0098526
name: inhibitory neuromuscular junction of somatic myotube
namespace: cellular_component
def: "A neuromuscular junction that functions in the inhibition of somatic muscle myotube contraction. Examples of somatic muscle myotubes include the somatic muscle cells of arthropods." [GOC:dos]
is_a: GO:0098521 ! inhibitory neuromuscular junction
is_a: GO:0098524 ! neuromuscular junction of somatic muscle myotube
created_by: davidos
creation_date: 2013-10-14T12:06:43Z

[Term]
id: GO:0098527
name: neuromuscular junction of somatic muscle
namespace: cellular_component
def: "A neuromuscular junction in which the target muscle cell is a somatic muscle cell, such as those found in nematodes and arthropods." [GOC:dos]
is_a: GO:0031594 ! neuromuscular junction
created_by: davidos
creation_date: 2013-10-14T12:07:05Z

[Term]
id: GO:0098528
name: skeletal muscle fiber differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle fiber cell. Skeletal muscle fiber differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual skeletal muscle fibers fuse to form bigger myotubes and start to contract." [GOC:dos]
is_a: GO:0014902 ! myotube differentiation
is_a: GO:0035914 ! skeletal muscle cell differentiation
created_by: davidos
creation_date: 2013-10-15T14:00:34Z

[Term]
id: GO:0098529
name: neuromuscular junction development, skeletal muscle fiber
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction that targets a skeletal muscle fiber." [GOC:mtg_OBO2OWL_2013]
is_a: GO:0007528 ! neuromuscular junction development
relationship: part_of GO:0048741 ! skeletal muscle fiber development

[Term]
id: GO:0098530
name: positive regulation of strand invasion
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of strand invasion. Strand invasion is the process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules." [GOC:dos, GOC:dph, GOC:elh, GOC:tb]
synonym: "positive regulation of D-loop biosynthesis" RELATED [GOC:elh]
synonym: "positive regulation of D-loop formation" RELATED [GOC:elh]
synonym: "positive regulation of Rad51-mediated strand invasion" EXACT [GOC:elh]
is_a: GO:0045911 ! positive regulation of DNA recombination
is_a: GO:0060542 ! regulation of strand invasion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042148 ! strand invasion
relationship: positively_regulates GO:0042148 ! strand invasion
created_by: davidos
creation_date: 2013-10-16T12:15:59Z

[Term]
id: GO:0098531
name: transcription factor activity, direct ligand regulated sequence-specific DNA binding
namespace: molecular_function
def: "A DNA binding transcription factor activity that is directly regulated by binding of a ligand to the protein with this activity.  Examples include the lac and trp repressors in E.coli and many steroid hormone receptors." [GOC:dos, http://www.ecocyc.org/ECOLI/NEW-IMAGE?object=BC-3.1.2.3]
synonym: "direct ligand regulated sequence-specific DNA binding transcription factor activity" EXACT []
is_a: GO:0003700 ! transcription factor activity, sequence-specific DNA binding
created_by: davidos
creation_date: 2013-10-17T15:51:30Z

[Term]
id: GO:0098532
name: histone H3-K27 trimethylation
namespace: biological_process
def: "The modification of histone H3 by addition of three methyl groups to lysine at position 27 of the histone." [PMID:19270745]
is_a: GO:0070734 ! histone H3-K27 methylation
created_by: davidos
creation_date: 2013-10-18T14:11:17Z

[Term]
id: GO:0098533
name: ATPase dependent transmembrane transport complex
namespace: cellular_component
def: "A transmembrane protein complex that functions in ATPase dependent active transport across a membrane." [GOC:dos]
comment: The location of this complex is implicit in its activity, so its location is asserted as a regular relationship rather than as a part of an intersection.
is_a: GO:1902495 ! transmembrane transporter complex
is_a: GO:1904949 ! ATPase complex
relationship: part_of GO:0016020 ! membrane
created_by: davidos
creation_date: 2013-10-22T12:12:52Z

[Term]
id: GO:0098534
name: centriole assembly
namespace: biological_process
def: "A cellular process that results in the assembly of one or more centrioles." [GOC:dos, PMID:24075808]
is_a: GO:0007017 ! microtubule-based process
is_a: GO:0070925 ! organelle assembly
is_a: GO:1902589 ! single-organism organelle organization
created_by: davidos
creation_date: 2013-10-22T15:55:22Z

[Term]
id: GO:0098535
name: de novo centriole assembly
namespace: biological_process
def: "Centriole assembly in which a centriole arises de novo by a process involving an electron dense structure known as a deuterosome, rather than by duplication of an existing centriole." [GOC:dos, PMID:24075808, PMID:5111878, PMID:5661997]
synonym: "centriole amplification" RELATED [PMID:24075808]
is_a: GO:0098534 ! centriole assembly
created_by: davidos
creation_date: 2013-10-22T16:03:13Z

[Term]
id: GO:0098536
name: deuterosome
namespace: cellular_component
def: "A spherical, electron dense, cytoplasmic structure that is involved in de novo assembly of centrioles." [GOC:dos, PMID:24075808, PMID:5661997]
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle
created_by: davidos
creation_date: 2013-10-22T16:21:19Z

[Term]
id: GO:0098537
name: lobed nucleus
namespace: cellular_component
def: "Nucleus with two or more lobes connected by a thin filament that contains no internal chromatin.  Examples include the nuclei of mature basophils, eosinophils and neutrophils in mice and humans." [GOC:dos, GOC:tfm]
is_a: GO:0005634 ! nucleus
created_by: davidos
creation_date: 2013-10-22T18:31:36Z

[Term]
id: GO:0098538
name: lumenal side of transport vesicle membrane
namespace: cellular_component
def: "The side (leaflet) of the transport vesicle membrane that faces the lumen." [GOC:ab]
synonym: "internal side of transport vesicle membrane" EXACT []
is_a: GO:0044433 ! cytoplasmic vesicle part
is_a: GO:0098576 ! lumenal side of membrane
relationship: part_of GO:0030658 ! transport vesicle membrane
created_by: davidos
creation_date: 2013-10-24T11:43:55Z

[Term]
id: GO:0098539
name: cytoplasmic side of transport vesicle membrane
namespace: cellular_component
def: "The side (leaflet) of the transport vesicle membrane that faces the cytoplasm." [GOC:ab]
synonym: "external side of transport vesicle membrane" EXACT []
is_a: GO:0044433 ! cytoplasmic vesicle part
is_a: GO:0098562 ! cytoplasmic side of membrane
relationship: part_of GO:0030658 ! transport vesicle membrane
created_by: davidos
creation_date: 2013-10-24T11:48:07Z

[Term]
id: GO:0098540
name: lumenal side of trans-Golgi network transport vesicle membrane
namespace: cellular_component
def: "The side (leaflet) of the trans-Golgi network transport vesicle membrane that faces the lumen." [GOC:ab]
synonym: "internal side of trans-Golgi network transport vesicle membrane" RELATED []
is_a: GO:0098538 ! lumenal side of transport vesicle membrane
is_a: GO:0098547 ! lumenal side of Golgi membrane
relationship: part_of GO:0012510 ! trans-Golgi network transport vesicle membrane
created_by: davidos
creation_date: 2013-10-24T11:55:02Z

[Term]
id: GO:0098541
name: cytoplasmic side of trans-Golgi network transport vesicle membrane
namespace: cellular_component
def: "The side (leaflet) of the trans-Golgi network transport vesicle membrane that faces the cytoplasm." [GOC:ab]
synonym: "external side of trans-Golgi network transport vesicle membrane" EXACT []
is_a: GO:0098539 ! cytoplasmic side of transport vesicle membrane
is_a: GO:0098548 ! cytoplasmic side of Golgi membrane
relationship: part_of GO:0012510 ! trans-Golgi network transport vesicle membrane
created_by: davidos
creation_date: 2013-10-24T11:56:30Z

[Term]
id: GO:0098542
name: defense response to other organism
namespace: biological_process
def: "Reactions triggered in response to the presence of another organism that act to protect the cell or organism from damage caused by that organism." [GOC:dos]
is_a: GO:0006952 ! defense response
is_a: GO:0051707 ! response to other organism
created_by: davidos
creation_date: 2013-11-11T12:59:11Z

[Term]
id: GO:0098543
name: detection of other organism
namespace: biological_process
def: "The series of events in which a stimulus from another organism is received and converted into a molecular signal." [GOC:dos]
is_a: GO:0051707 ! response to other organism
is_a: GO:0098581 ! detection of external biotic stimulus
created_by: davidos
creation_date: 2013-11-11T14:28:54Z

[Term]
id: GO:0098544
name: maintenance of protein complex location
namespace: biological_process
def: "Any process in which a protein complex is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of protein complexes that move away." [GOC:dos]
is_a: GO:0031503 ! protein complex localization
is_a: GO:0051235 ! maintenance of location
created_by: davidos
creation_date: 2013-11-15T18:20:16Z

[Term]
id: GO:0098545
name: maintenance of protein complex location in cytoplasm
namespace: biological_process
def: "Any process in which a protein complex is maintained in a specific location within the cytoplasm and is prevented from moving elsewhere." [GOC:dos]
is_a: GO:0098544 ! maintenance of protein complex location
relationship: occurs_in GO:0005737 ! cytoplasm
created_by: davidos
creation_date: 2013-11-15T20:49:15Z

[Term]
id: GO:0098546
name: 2',5-3',5'-cyclic GMP-AMP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with c[G(2',5')pA(2',5')p], a cyclic purine dinucleotide that consists of AMP and GMP units cyclized via 2',5' and 3',5' linkages." [GOC:dos, PMID:23910378]
synonym: "c[G(2',5')pA(3',5')p] binding" EXACT [PMID:23910378]
is_a: GO:0030551 ! cyclic nucleotide binding
is_a: GO:0032559 ! adenyl ribonucleotide binding
is_a: GO:0032561 ! guanyl ribonucleotide binding
created_by: davidos
creation_date: 2013-12-03T15:31:39Z

[Term]
id: GO:0098547
name: lumenal side of Golgi membrane
namespace: cellular_component
def: "The side of the Golgi membrane that faces the lumen." [GOC:ab, GOC:dos]
is_a: GO:0044431 ! Golgi apparatus part
is_a: GO:0098576 ! lumenal side of membrane
relationship: part_of GO:0000139 ! Golgi membrane
created_by: davidos
creation_date: 2013-12-03T10:44:23Z

[Term]
id: GO:0098548
name: cytoplasmic side of Golgi membrane
namespace: cellular_component
def: "The side (leaflet) of the Golgi membrane that faces the cytoplasm." [GOC:ab, GOC:dos]
is_a: GO:0044431 ! Golgi apparatus part
is_a: GO:0098562 ! cytoplasmic side of membrane
relationship: part_of GO:0000139 ! Golgi membrane
created_by: davidos
creation_date: 2013-12-03T10:49:33Z

[Term]
id: GO:0098549
name: somatic ring canal
namespace: cellular_component
def: "A stable intercellular bridge between somatic cells.  Examples include the intercellular bridges between ovarian follicle cells in insects and between imaginal disc cells in insects." [GOC:dos, PMID:22135360, PMID:670316]
is_a: GO:0045171 ! intercellular bridge

[Term]
id: GO:0098550
name: lumenal side of early endosome membrane
namespace: cellular_component
def: "The side (leaflet) of the early endosome membrane that faces the lumen." [GOC:lr]
synonym: "internal leaflet of early endosome membrane" EXACT [GOC:ab]
synonym: "internal side of early endosome membrane" EXACT []
is_a: GO:0098565 ! lumenal side of endosome membrane
relationship: part_of GO:0031901 ! early endosome membrane

[Term]
id: GO:0098551
name: lumenal side of late endosome membrane
namespace: cellular_component
def: "The side (leaflet) of the late endosome membrane that faces the cytoplasm." [GOC:lr]
synonym: "internal leaflet of late endosome membrane" EXACT [GOC:ab]
synonym: "internal side of late endosome membrane" EXACT []
is_a: GO:0098565 ! lumenal side of endosome membrane
relationship: part_of GO:0031902 ! late endosome membrane

[Term]
id: GO:0098552
name: side of membrane
namespace: cellular_component
def: "A cellular component consisting of one leaflet of a membrane bilayer and any proteins embedded or anchored in it or attached to its surface." [GOC:dos]
is_a: GO:0044425 ! membrane part
relationship: has_part GO:0097478 ! leaflet of membrane bilayer
relationship: part_of GO:0016020 ! membrane
created_by: davidos
creation_date: 2013-12-03T11:28:04Z

[Term]
id: GO:0098553
name: lumenal side of endoplasmic reticulum membrane
namespace: cellular_component
def: "The side (leaflet) of the plasma membrane that faces the lumen." [GOC:ab, GOC:dos]
is_a: GO:0044432 ! endoplasmic reticulum part
is_a: GO:0098576 ! lumenal side of membrane
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane
created_by: davidos
creation_date: 2013-12-03T12:08:37Z

[Term]
id: GO:0098554
name: cytoplasmic side of endoplasmic reticulum membrane
namespace: cellular_component
def: "The side (leaflet) of the plasma membrane that faces the cytoplasm." [GOC:ab, GOC:dos]
is_a: GO:0044432 ! endoplasmic reticulum part
is_a: GO:0098562 ! cytoplasmic side of membrane
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane
created_by: davidos
creation_date: 2013-12-03T12:09:47Z

[Term]
id: GO:0098555
name: lumenal side of rough endoplasmic reticulum membrane
namespace: cellular_component
def: "The side (leaflet) of the rough endoplasmic reticulum membrane that faces the lumen." [GOC:ab, GOC:dos]
is_a: GO:0098553 ! lumenal side of endoplasmic reticulum membrane
relationship: part_of GO:0030867 ! rough endoplasmic reticulum membrane
created_by: davidos
creation_date: 2013-12-03T12:13:24Z

[Term]
id: GO:0098556
name: cytoplasmic side of rough endoplasmic reticulum membrane
namespace: cellular_component
def: "The side (leaflet) of the rough endoplasmic reticulum membrane that faces the cytoplasm." [GOC:ab, GOC:dos]
is_a: GO:0098554 ! cytoplasmic side of endoplasmic reticulum membrane
relationship: part_of GO:0030867 ! rough endoplasmic reticulum membrane
created_by: davidos
creation_date: 2013-12-03T12:15:44Z

[Term]
id: GO:0098557
name: cytoplasmic side of smooth endoplasmic reticulum membrane
namespace: cellular_component
def: "The side (leaflet) of the smooth endoplasmic reticulum membrane that faces the cytoplasm." [GOC:ab, GOC:dos]
is_a: GO:0097425 ! smooth endoplasmic reticulum part
is_a: GO:0098554 ! cytoplasmic side of endoplasmic reticulum membrane
relationship: part_of GO:0030868 ! smooth endoplasmic reticulum membrane
created_by: davidos
creation_date: 2013-12-03T12:17:58Z

[Term]
id: GO:0098558
name: lumenal side of smooth endoplasmic reticulum membrane
namespace: cellular_component
def: "The side (leaflet) of the smooth endoplasmic reticulum membrane that faces the lumen." [GOC:ab, GOC:dos]
is_a: GO:0097425 ! smooth endoplasmic reticulum part
is_a: GO:0098553 ! lumenal side of endoplasmic reticulum membrane
relationship: part_of GO:0030868 ! smooth endoplasmic reticulum membrane
created_by: davidos
creation_date: 2013-12-03T12:19:28Z

[Term]
id: GO:0098559
name: cytoplasmic side of early endosome membrane
namespace: cellular_component
def: "The side (leaflet) of the early endosome membrane that faces the cytoplasm." [GOC:lr]
comment: In GO, 'external side' still refers to part of the membrane and does not refer to components beyond (outside of) the membrane.
synonym: "external leaflet of early endosome membrane" EXACT [GOC:ab]
synonym: "external side of early endosome membrane" EXACT []
is_a: GO:0010009 ! cytoplasmic side of endosome membrane
relationship: part_of GO:0031901 ! early endosome membrane

[Term]
id: GO:0098560
name: cytoplasmic side of late endosome membrane
namespace: cellular_component
def: "The side (leaflet) of the late endosome membrane that faces the cytoplasm." [GOC:lr]
comment: In GO, 'external side' still refers to part of the membrane and does not refer to components beyond (outside of) the membrane.
synonym: "external leaflet of late endosome membrane" EXACT [GOC:ab]
synonym: "external side of late endosome membrane" EXACT []
is_a: GO:0010009 ! cytoplasmic side of endosome membrane
relationship: part_of GO:0031902 ! late endosome membrane

[Term]
id: GO:0098561
name: methyl accepting chemotaxis protein complex
namespace: cellular_component
def: "A transmembrane protein complex that consists of multiple methyl-accepting chemoreceptor protein subunits, a histidine kinase and a connector protein and which functions in the regulation of flagellar rotary motor activity in response to an external chemical stimulus." [GOC:dos, PMID:1326408, PMID:15802240]
comment: A number of complexes of this class are found in E.coli.
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0098562
name: cytoplasmic side of membrane
namespace: cellular_component
def: "The side of a membrane that faces the cytoplasm." [GOC:dos]
is_a: GO:0098552 ! side of membrane
created_by: davidos
creation_date: 2013-12-12T11:21:30Z

[Term]
id: GO:0098563
name: intrinsic component of synaptic vesicle membrane
namespace: cellular_component
def: "The component of the synaptic vesicle membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos]
subset: goslim_synapse
is_a: GO:0031300 ! intrinsic component of organelle membrane
is_a: GO:0044433 ! cytoplasmic vesicle part
is_a: GO:0044456 ! synapse part
is_a: GO:0097458 ! neuron part
intersection_of: GO:0031224 ! intrinsic component of membrane
intersection_of: part_of GO:0030672 ! synaptic vesicle membrane
relationship: part_of GO:0030672 ! synaptic vesicle membrane

[Term]
id: GO:0098564
name: trans-Golgi network transport vesicle lumen
namespace: cellular_component
def: "The volume enclosed within the membrane of a trans-Golgi network transport vesicle." [GOC:dos]
is_a: GO:0005796 ! Golgi lumen
is_a: GO:0098566 ! transport vesicle lumen
relationship: part_of GO:0030140 ! trans-Golgi network transport vesicle

[Term]
id: GO:0098565
name: lumenal side of endosome membrane
namespace: cellular_component
def: "The side (leaflet) of the endosome membrane that faces the lumen." [GOC:dos]
synonym: "internal leaflet of endosome membrane" EXACT [GOC:ab]
synonym: "internal side of endosome membrane" EXACT []
is_a: GO:0044440 ! endosomal part
is_a: GO:0098576 ! lumenal side of membrane
relationship: part_of GO:0010008 ! endosome membrane

[Term]
id: GO:0098566
name: transport vesicle lumen
namespace: cellular_component
def: "The volume enclosed within the membrane of a transport vesicle." [GOC:dos]
is_a: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen
relationship: part_of GO:0030133 ! transport vesicle

[Term]
id: GO:0098567
name: periplasmic side of plasma membrane
namespace: cellular_component
def: "The side (leaflet) of a plasma membrane that faces the periplasm, and all proteins embedded in it or attached to its surface." [GOC:dos]
is_a: GO:0009897 ! external side of plasma membrane
created_by: davidos
creation_date: 2013-12-19T09:31:30Z

[Term]
id: GO:0098568
name: external side of mycolate outer membrane
namespace: cellular_component
def: "The side (leaflet) of the mycolate outer membrane that faces the environment and any proteins embedded in it or loosely bound to its surface." [GOC:dos, PMID:18316738, PMID:18567661]
is_a: GO:0031240 ! external side of cell outer membrane

[Term]
id: GO:0098569
name: internal side of mycolate outer membrane
namespace: cellular_component
def: "The side of the mycolate outer membrane that faces the cell wall peptidoglycan. It is rich in long-chain mycolic acids (hydroxylated branched-chain fatty acids) that are covalently linked to the cell wall peptidoglycan via an arabinogalactan network." [GOC:dos, PMID:18316738, PMID:18567661]
is_a: GO:0098552 ! side of membrane

[Term]
id: GO:0098570
name: stromal side of plastid inner membrane
namespace: cellular_component
def: "The side (leaflet) of the plastid inner membrane that faces the stroma, and any proteins embedded in it or loosely bound to its surface." [GOC:dos]
is_a: GO:0044435 ! plastid part
is_a: GO:0098552 ! side of membrane
relationship: part_of GO:0009528 ! plastid inner membrane

[Term]
id: GO:0098571
name: lumenal side of plastid thylakoid membrane
namespace: cellular_component
def: "The side (leaflet) of the plastid thylakoid membrane that faces the lumen, and any proteins embedded in it or loosely bound to its surface." [GOC:dos]
is_a: GO:0044435 ! plastid part
is_a: GO:0044436 ! thylakoid part
is_a: GO:0098552 ! side of membrane
relationship: part_of GO:0055035 ! plastid thylakoid membrane

[Term]
id: GO:0098572
name: stromal side of plastid thylakoid membrane
namespace: cellular_component
def: "The side (leaflet) of the plastid thylakoid membrane that faces the stroma, and any proteins embedded in it or loosely bound to its surface." [GOC:dos]
is_a: GO:0044435 ! plastid part
is_a: GO:0044436 ! thylakoid part
is_a: GO:0098552 ! side of membrane
relationship: part_of GO:0055035 ! plastid thylakoid membrane

[Term]
id: GO:0098573
name: intrinsic component of mitochondrial membrane
namespace: cellular_component
def: "The component of the mitochondrial membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos]
synonym: "intrinsic to mitochondrial membrane" NARROW []
is_a: GO:0031300 ! intrinsic component of organelle membrane
is_a: GO:0044455 ! mitochondrial membrane part
intersection_of: GO:0031224 ! intrinsic component of membrane
intersection_of: part_of GO:0031966 ! mitochondrial membrane
relationship: part_of GO:0031966 ! mitochondrial membrane

[Term]
id: GO:0098574
name: cytoplasmic side of lysosomal membrane
namespace: cellular_component
def: "The side (leaflet) of the lysosomal membrane that faces the cytoplasm." [GOC:ab, GOC:dos]
synonym: "external leaflet of lysosomal membrane" EXACT [GOC:dos]
synonym: "external side of lysosomal membrane" EXACT []
is_a: GO:0044437 ! vacuolar part
is_a: GO:0098562 ! cytoplasmic side of membrane
relationship: part_of GO:0005765 ! lysosomal membrane

[Term]
id: GO:0098575
name: lumenal side of lysosomal membrane
namespace: cellular_component
def: "The side (leaflet) of the lysosomal membrane that faces the lumen." [GOC:dos]
synonym: "internal leaflet of lysosomal membrane" EXACT [GOC:ab]
synonym: "internal side of lysosomal membrane" EXACT []
is_a: GO:0044437 ! vacuolar part
is_a: GO:0098576 ! lumenal side of membrane
relationship: part_of GO:0005765 ! lysosomal membrane

[Term]
id: GO:0098576
name: lumenal side of membrane
namespace: cellular_component
def: "Any side (leaflet) of a membrane that faces the lumen of an organelle." [GOC:dos]
is_a: GO:0044422 ! organelle part
is_a: GO:0098552 ! side of membrane
relationship: part_of GO:0031090 ! organelle membrane

[Term]
id: GO:0098577
name: inactive sex chromosome
namespace: cellular_component
def: "A sex chromosome that has been inactivated." [GOC:dos]
synonym: "inactivated sex chromosome" EXACT []
is_a: GO:0000803 ! sex chromosome

[Term]
id: GO:0098578
name: condensed chromatin of inactivated sex chromosome
namespace: cellular_component
def: "A condensed form of chromatin that is associated with an inactivated sex chromosome and which is responsible for its inactivation." [GOC:dos]
is_a: GO:0001739 ! sex chromatin
intersection_of: GO:0005720 ! nuclear heterochromatin
intersection_of: part_of GO:0098577 ! inactive sex chromosome
relationship: part_of GO:0098577 ! inactive sex chromosome

[Term]
id: GO:0098579
name: active sex chromosome
namespace: cellular_component
def: "A sex chromosome that has not been inactivated." [GOC:dos]
is_a: GO:0000803 ! sex chromosome

[Term]
id: GO:0098580
name: chromatin of active sex chromosome
namespace: cellular_component
def: "Chromatin that is part of an active sex chromosome." [GOC:dos, PMID:23816838]
comment: Some gene products are known to be associated  with the chromatin of active sex chromosome, but not that of inactive sex chromosomes or autosome, e.g. see: Froberg et al., 2003 (PMID:23816838).
is_a: GO:0001739 ! sex chromatin
intersection_of: GO:0000790 ! nuclear chromatin
intersection_of: part_of GO:0098579 ! active sex chromosome
relationship: part_of GO:0098579 ! active sex chromosome

[Term]
id: GO:0098581
name: detection of external biotic stimulus
namespace: biological_process
def: "The series of events in which an external biotic stimulus is detected and converted into a molecular signal.  An external biotic stimulus is defined as one caused or produced by a living organism other than the one being stimulated." [GOC:dos]
synonym: "detection of exogenous biotic stimulus" EXACT []
is_a: GO:0009595 ! detection of biotic stimulus
is_a: GO:0043207 ! response to external biotic stimulus
created_by: davidos
creation_date: 2014-01-22T14:20:16Z

[Term]
id: GO:0098582
name: innate vocalization behavior
namespace: biological_process
def: "A vocalisation behavior that is innate, i.e. that does not need to be learned in order to occur." [GOC:BHF, GOC:dos, GOC:rl]
is_a: GO:0071625 ! vocalization behavior
created_by: davidos
creation_date: 2014-01-24T12:47:01Z

[Term]
id: GO:0098583
name: learned vocalization behavior
namespace: biological_process
def: "A vocalization behavior that is the result of learning." [GOC:BHF, GOC:dos, GOC:rl, PMID:16418265, PMID:17035521]
comment: Examples include human speech and learned bird song.
is_a: GO:0071625 ! vocalization behavior
is_a: GO:0098598 ! learned vocalization behavior or vocal learning
created_by: davidos
creation_date: 2014-01-24T12:48:57Z

[Term]
id: GO:0098584
name: host cell synaptic vesicle
namespace: cellular_component
def: "A secretory organelle of a host cell, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [GOC:dos]
is_a: GO:0044161 ! host cell cytoplasmic vesicle
relationship: part_of GO:0044221 ! host cell synapse
created_by: davidos
creation_date: 2014-01-24T13:14:13Z

[Term]
id: GO:0098585
name: host cell synaptic vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a host synaptic vesicle." [GOC:dos]
is_a: GO:0044162 ! host cell cytoplasmic vesicle membrane
relationship: part_of GO:0098584 ! host cell synaptic vesicle
created_by: davidos
creation_date: 2014-01-24T13:15:14Z

[Term]
id: GO:0098586
name: cellular response to virus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus." [GOC:dos]
is_a: GO:0009615 ! response to virus
created_by: davidos
creation_date: 2014-01-24T14:54:08Z

[Term]
id: GO:0098588
name: bounding membrane of organelle
namespace: cellular_component
def: "The lipid bilayer that forms the outer-most layer of an organelle." [GOC:dos]
comment: Examples include the outer membranes of double membrane bound organelles such as mitochondria as well as the bounding membranes of single-membrane bound organelles such as lysosomes.
is_a: GO:0031090 ! organelle membrane
created_by: davidos
creation_date: 2014-02-26T13:41:31Z

[Term]
id: GO:0098589
name: membrane region
namespace: cellular_component
def: "A membrane that is a part of a larger membrane.  Examples include the apical region of the plasma membrane of an epithelial cell and the various regions of the endoplasmic reticulum membrane." [GOC:dos]
comment: Note that this term should not be used for direct manual annotation as it should always be possible to choose a more specific subclass.
subset: gocheck_do_not_manually_annotate
synonym: "region of membrane" EXACT []
is_a: GO:0016020 ! membrane
is_a: GO:0044425 ! membrane part
intersection_of: GO:0016020 ! membrane
intersection_of: part_of GO:0098805 ! whole membrane
disjoint_from: GO:0098805 ! whole membrane
relationship: part_of GO:0098805 ! whole membrane
creation_date: 2014-03-06T11:37:54Z

[Term]
id: GO:0098590
name: plasma membrane region
namespace: cellular_component
def: "A membrane that is a (regional) part of the plasma membrane." [GOC:dos]
comment: Note that this term should not be used for direct manual annotation as it should always be possible to choose a more specific subclass.
subset: gocheck_do_not_manually_annotate
synonym: "region of plasma membrane" EXACT []
is_a: GO:0044459 ! plasma membrane part
is_a: GO:0098589 ! membrane region
intersection_of: GO:0016020 ! membrane
intersection_of: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0005886 ! plasma membrane
created_by: davidos
creation_date: 2014-03-06T11:55:32Z

[Term]
id: GO:0098591
name: external side of apical plasma membrane
namespace: cellular_component
def: "The leaflet the apical region of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:ab, GOC:dos]
is_a: GO:0009897 ! external side of plasma membrane
relationship: part_of GO:0016324 ! apical plasma membrane
created_by: davidos
creation_date: 2014-03-06T12:04:33Z

[Term]
id: GO:0098592
name: cytoplasmic side of apical plasma membrane
namespace: cellular_component
def: "The side (leaflet) of the apical region of the plasma membrane that faces the cytoplasm." [GOC:ab, GOC:dos]
is_a: GO:0009898 ! cytoplasmic side of plasma membrane
relationship: part_of GO:0016324 ! apical plasma membrane
created_by: davidos
creation_date: 2014-03-06T12:07:32Z

[Term]
id: GO:0098593
name: goblet cell theca
namespace: cellular_component
def: "A cup shaped specialization of the cytoskeleton that forms a thin layer located just below the apical mass of mature mucin secretory granules in the cytoplasm of goblet cells of the intestinal epithelium.  It consists of an orderly network of intermediate filaments and microtubules. Microtubules are arranged vertically, like barrel staves, along the inner aspect of the theta. Intermediate filaments form two networks: an inner, basketlike network and an outer series of circumferential bundles resembling the hoops of a barrel." [PMID:6541604]
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0005737 ! cytoplasm
relationship: part_of GO:0005856 ! cytoskeleton
created_by: davidos
creation_date: 2014-03-11T14:52:33Z

[Term]
id: GO:0098594
name: mucin granule
namespace: cellular_component
def: "A secretory granule that contains mucin." [PMID:16377632]
is_a: GO:0030141 ! secretory granule
created_by: davidos
creation_date: 2014-03-11T15:59:11Z

[Term]
id: GO:0098595
name: perivitelline space
namespace: cellular_component
def: "The space between the membrane of an oocyte and a surrounding membranous structure (zona pellucida or perivitelline membrane)." [GOC:dos]
is_a: GO:0005576 ! extracellular region
created_by: davidos
creation_date: 2014-04-08T16:07:31Z

[Term]
id: GO:0098596
name: imitative learning
namespace: biological_process
def: "Learning in which new behaviors are acquired through imitation." [GOC:dos, Wikipedia:Imitative_learning&oldid=593192364]
xref: Wikipedia:Imitative_learning
xref: Wikipedia:Observational_learning#Observational_learning_compared_to_imitation
is_a: GO:0098597 ! observational learning
created_by: davidos
creation_date: 2014-04-10T11:00:39Z

[Term]
id: GO:0098597
name: observational learning
namespace: biological_process
def: "Learning that occurs through observing the behavior of others." [GOC:dos, Wikipedia:Observational_learning&oldid=603524137]
comment: Observation here is used in a broad sense to include perception of the behavior of others via any form or combination of forms of sensory perception (visual, auditory etc). Observational learning is broader than imitative learning in that it does not require a duplication of the behavior exhibited by the model.
xref: Wikipedia:Observational_learning
is_a: GO:0007612 ! learning
created_by: davidos
creation_date: 2014-04-10T11:07:10Z

[Term]
id: GO:0098598
name: learned vocalization behavior or vocal learning
namespace: biological_process
def: "Vocalisation behavior that is the result of learning, or the process by which new vocalizations are learned." [GOC:BHF, GOC:dos, GOC:rl, PMID:16418265, PMID:17035521]
comment: This grouping term is necessary because, in the absence of conditional mutations, it is not possible to use phenotypic evidence to distinguish an effect on vocal learning from an effect on learned vocalisation behavior.
is_a: GO:0007611 ! learning or memory
created_by: davidos
creation_date: 2014-04-10T11:34:33Z

[Term]
id: GO:0098599
name: palmitoyl hydrolase activity
namespace: molecular_function
def: "Catalysis of a hydrolase reaction that removes a palmitoyl moiety from some substrate." [GOC:dos, GOC:pg]
is_a: GO:0016787 ! hydrolase activity
relationship: part_of GO:0098734 ! macromolecule depalmitoylation
created_by: davidos
creation_date: 2014-04-11T17:57:36Z

[Term]
id: GO:0098600
name: selenomethionine gamma-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-Selenomethionine + H2O => Methaneselenol + Ammonia + 2-oxobutanoic acid." [PMID:11578145, PMID:16037612, PMID:16444005]
is_a: GO:0016846 ! carbon-sulfur lyase activity
created_by: davidos
creation_date: 2014-04-15T15:00:28Z

[Term]
id: GO:0098601
name: selenomethionine adenosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-Selenomethionine + H2O => Orthophosphate + Diphosphate + Se-Adenosylselenomethionine." [PMID:2339986]
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups
created_by: davidos
creation_date: 2014-04-15T15:15:03Z

[Term]
id: GO:0098602
name: single organism cell adhesion
namespace: biological_process
def: "The attachment, via cell adhesion molecules, of a cell to either another cell of the same organism, or to an underlying substrate of the same organism such as the extracellular matrix." [GOC:dos]
is_a: GO:0007155 ! cell adhesion
is_a: GO:0044699 ! single-organism process
created_by: davidos
creation_date: 2014-04-15T15:59:10Z

[Term]
id: GO:0098603
name: selenol Se-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: R + Se-Adenosylselenomethionine => CH3-R + Se-Adenosyl-L-selenohomocysteine." [PMID:1711890]
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0098604
name: adenosylselenohomocysteinase activity
namespace: molecular_function
def: "Catalysis of the reaction: Se-Adenosyl-L-selenohomocysteine + H2O => Adenosine + Selenohomocysteine." [GOC:dos, PMID:1711890, PMID:7305945]
is_a: GO:0016802 ! trialkylsulfonium hydrolase activity
created_by: davidos
creation_date: 2014-04-16T10:53:22Z

[Term]
id: GO:0098605
name: selenocystathionine beta-synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-Serine + Selenohomocysteine => L-Selenocystathionine + H2O." [PMID:6456763]
is_a: GO:0016836 ! hydro-lyase activity
created_by: davidos
creation_date: 2014-04-16T11:07:50Z

[Term]
id: GO:0098606
name: selenocystathionine gamma-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-Selenocystathionine + H2O => L-Selenocysteine + NH3 + 2-Oxobutanoic acid." [PMID:6456763]
is_a: GO:0016846 ! carbon-sulfur lyase activity
created_by: davidos
creation_date: 2014-04-16T11:20:00Z

[Term]
id: GO:0098607
name: methylselenocysteine deselenhydrase activity
namespace: molecular_function
def: "Catalysis of the reaction: Se-Methyl-L-selenocysteine + H2O => pyruvic acid + NH3 + Methaneselenol." [PMID:17451884, PMID:20383543]
is_a: GO:0016846 ! carbon-sulfur lyase activity
created_by: davidos
creation_date: 2014-04-16T11:24:12Z

[Term]
id: GO:0098608
name: methylselenol demethylase activity
namespace: molecular_function
def: "Catalysis of the reaction: methylselenol + H2O => H2Se + CH3OH." [PMID:17451884, PMID:17988700]
is_a: GO:0032451 ! demethylase activity
created_by: davidos
creation_date: 2014-04-16T11:28:00Z

[Term]
id: GO:0098609
name: cell-cell adhesion
namespace: biological_process
def: "The attachment of one cell to another cell via adhesion molecules." [GOC:dos]
is_a: GO:0007155 ! cell adhesion
created_by: davidos
creation_date: 2014-04-16T13:40:03Z

[Term]
id: GO:0098610
name: adhesion between unicellular organisms
namespace: biological_process
def: "The attachment of two unicellular organisms to each other." [GOC:dos]
synonym: "multi-organismal cell-cell adhesion" BROAD []
is_a: GO:0098609 ! cell-cell adhesion
is_a: GO:0098740 ! multi organism cell adhesion

[Term]
id: GO:0098611
name: cell-cell adhesion involved in galactose-specific flocculation
namespace: biological_process
def: "Cell-cell adhesion between two single-celled organisms, during flocculation, mediated via the binding of cell wall proteins on one cell to galactose residues on the other." [GOC:dos, PMID:22098069]
is_a: GO:0043690 ! cell-cell adhesion involved in flocculation via cell wall protein-carbohydrate interaction
intersection_of: GO:0098741 ! adhesion between unicellular organisms via cell-wall interaction
intersection_of: part_of GO:0036349 ! galactose-specific flocculation
relationship: part_of GO:0036349 ! galactose-specific flocculation

[Term]
id: GO:0098612
name: cell-cell adhesion involved in mannose-specific flocculation
namespace: biological_process
def: "Cell-cell adhesion between two single-celled organisms, during flocculation, mediated via the binding of cell wall proteins on one cell to mannose residues on the other." [GOC:dos, PMID:22098069]
is_a: GO:0043690 ! cell-cell adhesion involved in flocculation via cell wall protein-carbohydrate interaction
intersection_of: GO:0098741 ! adhesion between unicellular organisms via cell-wall interaction
intersection_of: part_of GO:0036350 ! mannose-specific flocculation
relationship: part_of GO:0036350 ! mannose-specific flocculation

[Term]
id: GO:0098613
name: methaneselenol methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-Adenosyl-L-methionine + Methaneselenol => S-Adenosyl-L-homocysteine + Dimethyl selenide." [PMID:14705, PMID:17988700, PMID:4380351]
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0098614
name: hydrogen selenide methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-Adenosyl-L-methionine + Hydrogen selenide => S-Adenosyl-L-homocysteine + Methaneselenol." [PMID:14705, PMID:17988700]
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0098615
name: dimethyl selenide methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + dimethyl selenide => S-adenosyl-L-homocysteine + trimethylselenonium." [PMID:17988700, PMID:3350800]
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0098616
name: selenate adenylyltransferase (ATP) activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2SeO4 => Diphosphate + Adenylylselenate." [PMID:2537056]
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0098617
name: adenylylselenate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + Adenylylselenate => ADP + 3'-Phosphoadenylylselenate." [PMID:2537056]
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0098618
name: selenomethionine-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-Selenomethionine + tRNA(Met) => AMP + Diphosphate + Selenomethionyl-tRNA(Met)." [PMID:16661668, PMID:16661782]
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0098619
name: selenocysteine-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: tRNASec + L-Ser + ATP ---> Ser-tRNASec + AMP + Diphosphate." [PMID:8890909, PMID:9431993, PMID:9637248]
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0098620
name: seryl-selenocysteinyl-tRNA kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: Ser-tRNA(Sec) + ATP ---> Sep-tRNA(Sec) + ADP" [PMID:15317934]
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0098621
name: phosphoseryl-selenocysteinyl-tRNA selenium transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: O-Phosphoseryl-tRNA(Sec) + Selenophosphoric acid + H2O => L-Selenocysteinyl-tRNA(Sec) + 2 phosphoric acid." [PMID:17142313, PMID:19608919]
is_a: GO:0016785 ! transferase activity, transferring selenium-containing groups

[Term]
id: GO:0098622
name: selenodiglutathione-disulfide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + selenodiglutathione + NADPH => gluthathioselenol + glutathione + NADP+." [PMID:1569062]
is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor

[Term]
id: GO:0098623
name: selenite reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: SeO3(2-) + 3NADPH + 5H+ ---> H2Se + 3NADP+ + 3H2O." [PMID:1321713]
is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H

[Term]
id: GO:0098624
name: 3'-Phosphoadenylylselenate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-Phosphoadenylylselenate + NADPH => Adenosine 3',5'-bisphosphate + Selenite + NADP+ + H+." [PMID:14723223]
synonym: "PAPSe reductase activity" EXACT [PMID:14723223]
is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H

[Term]
id: GO:0098625
name: methylselenol reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADPH + H+ + CH3SeOH => NADP+ + CH3SeH + H2O" [PMID:11782468]
is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H

[Term]
id: GO:0098626
name: methylseleninic acid reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADPH + H+ + CH3SeO2H => NADP+ + CH3SeOH + H2O." [PMID:11782468]
is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H

[Term]
id: GO:0098627
name: protein arginine phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein arginine phosphate + H2O = protein arginine + phosphate." [PMID:23770242]
comment: Made part of peptidyl-N-phospho-arginine phosphatase activity on the assumption that arginine phosphorylation in proteins occurs via an N link.
is_a: GO:0004721 ! phosphoprotein phosphatase activity
relationship: part_of GO:0098628 ! peptidyl-N-phospho-arginine dephosphorylation
created_by: davidos
creation_date: 2014-04-17T17:57:39Z

[Term]
id: GO:0098628
name: peptidyl-N-phospho-arginine dephosphorylation
namespace: biological_process
def: "The removal of phosphate residues from peptidyl-N-phospho-arginine to form peptidyl-arginine" [PMID:23770242]
is_a: GO:0006470 ! protein dephosphorylation
created_by: davidos
creation_date: 2014-04-17T18:03:31Z

[Term]
id: GO:0098629
name: trans-Golgi network membrane organization
namespace: biological_process
def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of a trans-Golgi network membrane." [GOC:di, GOC:dos, PMID:23345439]
is_a: GO:0061024 ! membrane organization

[Term]
id: GO:0098630
name: aggregation of unicellular organisms
namespace: biological_process
def: "The clustering together of unicellular organisms in suspension form aggregates." [GOC:dos]
synonym: "aggregation of single cell organisms" EXACT []
is_a: GO:0044764 ! multi-organism cellular process
is_a: GO:0098743 ! cell aggregation

[Term]
id: GO:0098631
name: protein binding involved in cell adhesion
namespace: molecular_function
def: "Any protein binding that is involved in cell adhesion." [GOC:dos]
is_a: GO:0005515 ! protein binding
intersection_of: GO:0005515 ! protein binding
intersection_of: part_of GO:0007155 ! cell adhesion
relationship: part_of GO:0007155 ! cell adhesion

[Term]
id: GO:0098632
name: protein binding involved in cell-cell adhesion
namespace: molecular_function
def: "Any protein binding that is involved in cell-cell adhesion." [GOC:dos]
is_a: GO:0098631 ! protein binding involved in cell adhesion
intersection_of: GO:0005515 ! protein binding
intersection_of: part_of GO:0098609 ! cell-cell adhesion
relationship: part_of GO:0098609 ! cell-cell adhesion

[Term]
id: GO:0098633
name: collagen fibril binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a collagen fibril." [GOC:dos, PMID:21421911]
is_a: GO:0032403 ! protein complex binding

[Term]
id: GO:0098634
name: protein binding involved in cell-matrix adhesion
namespace: molecular_function
def: "Any protein binding that is involved in cell-matrix adhesion." [GOC:dos]
is_a: GO:0098631 ! protein binding involved in cell adhesion
intersection_of: GO:0005515 ! protein binding
intersection_of: part_of GO:0007160 ! cell-matrix adhesion
relationship: part_of GO:0007160 ! cell-matrix adhesion

[Term]
id: GO:0098635
name: protein complex involved in cell-cell adhesion
namespace: cellular_component
def: "Any protein complex that is capable of carrying out some part of the process of cell-cell adhesion." [GOC:dos]
is_a: GO:0098636 ! protein complex involved in cell adhesion

[Term]
id: GO:0098636
name: protein complex involved in cell adhesion
namespace: cellular_component
alt_id: GO:1990307
def: "Any protein complex that is capable of carrying out some part of the process of cell-cell adhesion." [GOC:dos]
synonym: "cell adhesion complex" RELATED []
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0098637
name: protein complex involved in cell-matrix adhesion
namespace: cellular_component
def: "Any protein complex that is capable of carrying out some part of the process of cell-matrix adhesion." [GOC:dos]
is_a: GO:0098636 ! protein complex involved in cell adhesion

[Term]
id: GO:0098638
name: laminin binding involved in cell-matrix adhesion
namespace: molecular_function
def: "Any laminin protein binding that occurs as part of cell-matrix adhesion." [GOC:dos]
is_a: GO:0043236 ! laminin binding
is_a: GO:0098634 ! protein binding involved in cell-matrix adhesion
intersection_of: GO:0043236 ! laminin binding
intersection_of: part_of GO:0007160 ! cell-matrix adhesion
relationship: part_of GO:0007160 ! cell-matrix adhesion

[Term]
id: GO:0098639
name: collagen binding involved in cell-matrix adhesion
namespace: molecular_function
def: "Any collagen binding that occurs as part of cell-matrix adhesion." [GOC:dos]
is_a: GO:0005518 ! collagen binding
is_a: GO:0098634 ! protein binding involved in cell-matrix adhesion
intersection_of: GO:0005518 ! collagen binding
intersection_of: part_of GO:0007160 ! cell-matrix adhesion
relationship: part_of GO:0007160 ! cell-matrix adhesion

[Term]
id: GO:0098640
name: integrin binding involved in cell-matrix adhesion
namespace: molecular_function
def: "Any integrin binding that occurs as part of the process of cell-matrix adhesion." [GOC:dos]
is_a: GO:0005178 ! integrin binding
is_a: GO:0098634 ! protein binding involved in cell-matrix adhesion
intersection_of: GO:0005178 ! integrin binding
intersection_of: part_of GO:0007160 ! cell-matrix adhesion
relationship: part_of GO:0007160 ! cell-matrix adhesion

[Term]
id: GO:0098641
name: cadherin binding involved in cell-cell adhesion
namespace: molecular_function
def: "Any cadherin binding that occurs as part of the process of cell-cell adhesion." [GOC:dos]
is_a: GO:0045296 ! cadherin binding
is_a: GO:0098632 ! protein binding involved in cell-cell adhesion
intersection_of: GO:0045296 ! cadherin binding
intersection_of: part_of GO:0098609 ! cell-cell adhesion
relationship: part_of GO:0098609 ! cell-cell adhesion

[Term]
id: GO:0098642
name: network-forming collagen trimer
namespace: cellular_component
def: "A collagen trimer that forms networks." [PMID:21421911]
is_a: GO:0005581 ! collagen trimer
is_a: GO:0044420 ! extracellular matrix component
is_a: GO:0044421 ! extracellular region part
intersection_of: GO:0005581 ! collagen trimer
intersection_of: part_of GO:0098645 ! collagen network
relationship: part_of GO:0098645 ! collagen network

[Term]
id: GO:0098643
name: banded collagen fibril
namespace: cellular_component
def: "A supramolecular assembly of fibrillar collagen complexes in the form of a long fiber (fibril) with transverse striations (bands)." [GOC:dos, PMID:21421911]
is_a: GO:0098644 ! complex of collagen trimers

[Term]
id: GO:0098644
name: complex of collagen trimers
namespace: cellular_component
def: "A complex of collagen trimers such as a fibril or collagen network." [GOC:dos]
synonym: "Supramolecular aggregate of collagen" EXACT [PMID:19693541]
synonym: "Supramolecular collagen assembly" EXACT [PMID:21421911]
is_a: GO:0043234 ! protein complex
is_a: GO:0044420 ! extracellular matrix component
is_a: GO:0044421 ! extracellular region part
relationship: has_part GO:0005581 ! collagen trimer
relationship: part_of GO:0005578 ! proteinaceous extracellular matrix

[Term]
id: GO:0098645
name: collagen network
namespace: cellular_component
def: "A protein complex that consists of collagen triple helices associated to form a network." [GOC:dos, PMID:21421911]
is_a: GO:0098644 ! complex of collagen trimers

[Term]
id: GO:0098646
name: collagen sheet
namespace: cellular_component
def: "A protein complex that consists of collagen triple helices associated to form a sheet-like network." [GOC:dos, PMID:21421911]
synonym: "collagen hexagonal network" EXACT [PMID:21421911]
is_a: GO:0098645 ! collagen network

[Term]
id: GO:0098647
name: collagen beaded filament
namespace: cellular_component
def: "A supramolecular assembly of collagen trimers with a 'beads on a string'-like structure." [GOC:dos, PMID:19693541]
synonym: "beads on a string" RELATED [PMID:19693541]
is_a: GO:0098644 ! complex of collagen trimers

[Term]
id: GO:0098648
name: collagen anchoring fibril
namespace: cellular_component
def: "A specialised collagen fibril that functions as an anchor, binding to other collagen structures." [GOC:dos]
is_a: GO:0098644 ! complex of collagen trimers

[Term]
id: GO:0098649
name: response to peptidyl-dipeptidase A inhibitor
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidyl-dipeptidase A inhibitor stimulus." [GOC:dos]
synonym: "response to ACE inhibitor" NARROW []
synonym: "response to angiotensin-converting enzyme inhibitor" NARROW []
is_a: GO:0042493 ! response to drug

[Term]
id: GO:0098650
name: peptidyl-proline 4-dioxygenase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a peptidyl-proline 4-dioxygenase." [GOC:dos, GOC:kvm]
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0098651
name: basement membrane collagen trimer
namespace: cellular_component
def: "Any collagen timer that is part of a basement membrane." [GOC:dos, PMID:21421911]
is_a: GO:0005581 ! collagen trimer
is_a: GO:0044420 ! extracellular matrix component
is_a: GO:0044421 ! extracellular region part
intersection_of: GO:0005581 ! collagen trimer
intersection_of: part_of GO:0005604 ! basement membrane
relationship: part_of GO:0005604 ! basement membrane

[Term]
id: GO:0098652
name: collagen type VII anchoring fibril
namespace: cellular_component
def: "An antiparallel dimer of two collagen VII trimers, one end of which is embedded in the lamina densa while the other end attaches to banded collagen fibrils in the dermis." [PMID:19693541]
is_a: GO:0098648 ! collagen anchoring fibril

[Term]
id: GO:0098653
name: centromere clustering
namespace: biological_process
alt_id: GO:0098587
def: "The process by which centromeres/kinetochores become localized to clusters." [GOC:di, GOC:dos, PMID:10761928, PMID:23283988, PMID:8486732]
comment: As inner kinetochores are an integral part of centromeres, we treat centromere and kinetochore clustering as the same process.
synonym: "kinetochore clustering" EXACT []
is_a: GO:0050000 ! chromosome localization
is_a: GO:0072765 ! centromere localization
created_by: davidos
creation_date: 2014-05-23T19:03:37Z

[Term]
id: GO:0098654
name: CENP-A recruiting complex
namespace: cellular_component
def: "A protein complex that includes Mis16(Yippee family) and/or Mis18 (WD repeat) subunits that is involved in the deposition of centromere specific (CENP-A containing) nucleosomes at the centromere." [PMID:24774534]
synonym: "MIS18 complex" NARROW [GOC:bhm, GOC:vw]
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0098655
name: cation transmembrane transport
namespace: biological_process
def: "A process in which a cation is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:dos, GOC:vw]
is_a: GO:0006812 ! cation transport
is_a: GO:0034220 ! ion transmembrane transport

[Term]
id: GO:0098656
name: anion transmembrane transport
namespace: biological_process
def: "A process in which an anion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:dos, GOC:vw]
is_a: GO:0006820 ! anion transport
is_a: GO:0034220 ! ion transmembrane transport

[Term]
id: GO:0098657
name: import into cell
namespace: biological_process
def: "The directed movement of some substance from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [GOC:dos]
synonym: "uptake" EXACT []
is_a: GO:0006810 ! transport

[Term]
id: GO:0098658
name: inorganic anion import into cell
namespace: biological_process
def: "The directed movement of inorganic anions from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [GOC:dos]
is_a: GO:0015698 ! inorganic anion transport
is_a: GO:0099587 ! inorganic ion import into cell

[Term]
id: GO:0098659
name: inorganic cation import into cell
namespace: biological_process
def: "The directed movement of inorganic cations from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [GOC:dos]
is_a: GO:0006812 ! cation transport
is_a: GO:0099587 ! inorganic ion import into cell

[Term]
id: GO:0098660
name: inorganic ion transmembrane transport
namespace: biological_process
def: "A process in which an inorganic ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "inorganic ion membrane transport" EXACT []
synonym: "transmembrane inorganic ion transport" EXACT [GOC:dph, GOC:tb]
is_a: GO:0034220 ! ion transmembrane transport

[Term]
id: GO:0098661
name: inorganic anion transmembrane transport
namespace: biological_process
def: "A process in which an inorganic anion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "inorganic anion membrane transport" EXACT []
synonym: "transmembrane inorganic anion transport" EXACT [GOC:dph, GOC:tb]
is_a: GO:0015698 ! inorganic anion transport
is_a: GO:0098656 ! anion transmembrane transport
is_a: GO:0098660 ! inorganic ion transmembrane transport

[Term]
id: GO:0098662
name: inorganic cation transmembrane transport
namespace: biological_process
def: "A process in which an inorganic cation is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "inorganic cation membrane transport" EXACT []
synonym: "transmembrane inorganic cation transport" EXACT [GOC:dph, GOC:tb]
is_a: GO:0098655 ! cation transmembrane transport
is_a: GO:0098660 ! inorganic ion transmembrane transport

[Term]
id: GO:0098663
name: transmembrane transporter activity involved in import into cell
namespace: molecular_function
def: "Any transmembrane transporter activity that is involved in importing some substance into a cell." [GOC:dos, ISBN:0-8249-3695-6]
is_a: GO:0022857 ! transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: part_of GO:0098657 ! import into cell
relationship: part_of GO:0098657 ! import into cell

[Term]
id: GO:0098687
name: chromosomal region
namespace: cellular_component
def: "Any subdivision of a chromosome along its length." [GOC:dos]
comment: Chromosomal regions include parts that are not part of the chromatin.  Examples include the kinetochore.
synonym: "chromosome region" EXACT []
is_a: GO:0044427 ! chromosomal part

[Term]
id: GO:0098700
name: neurotransmitter loading into synaptic vesicle
namespace: biological_process
def: "The active transport of neurotransmitters into a synaptic vesicle.  This import is fuelled by an electrochemical gradient across the vesicle membrane, established by the action proton pumps." [GOC:bf, GOC:pad, GOC:PARL, PMID:10099709, PMID:15217342]
subset: goslim_synapse
synonym: "neurotransmitter import into synaptic vesicle" EXACT []
synonym: "neurotransmitter uptake into synaptic vesicle" EXACT [PMID:15217342]
synonym: "synaptic vesicle neurotransmitter loading" EXACT []
is_a: GO:0006836 ! neurotransmitter transport
is_a: GO:0051649 ! establishment of localization in cell
relationship: part_of GO:0099504 ! synaptic vesicle cycle

[Term]
id: GO:0098701
name: endocytic import into cell
namespace: biological_process
def: "The directed movement of some substance from the outside of a cell into a cytoplasmic vesicle via endocytosis." [GOC:dos]
comment: Examples include endocytic import involved in transcellular transport, e.g. of glucose across the gut epithelial cells.
is_a: GO:0016192 ! vesicle-mediated transport
is_a: GO:0098657 ! import into cell

[Term]
id: GO:0098702
name: adenine import across plasma membrane
namespace: biological_process
def: "The directed movement of adenine from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]
is_a: GO:0061488 ! adenine import into cell
is_a: GO:0098739 ! import across plasma membrane
is_a: GO:1904823 ! purine nucleobase transmembrane transport

[Term]
id: GO:0098703
name: calcium ion import across plasma membrane
namespace: biological_process
def: "The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]
is_a: GO:0097553 ! calcium ion transmembrane import into cytosol
is_a: GO:0098739 ! import across plasma membrane
is_a: GO:1990035 ! calcium ion import into cell

[Term]
id: GO:0098704
name: carbohydrate import across plasma membrane
namespace: biological_process
def: "The directed movement of a carbohydrate from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]
is_a: GO:0034219 ! carbohydrate transmembrane transport
is_a: GO:0097319 ! carbohydrate import into cell
is_a: GO:0098739 ! import across plasma membrane

[Term]
id: GO:0098705
name: copper ion import across plasma membrane
namespace: biological_process
def: "The directed movement of copper ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]
is_a: GO:0015679 ! plasma membrane copper ion transport
is_a: GO:0098739 ! import across plasma membrane
is_a: GO:1902861 ! copper ion import into cell

[Term]
id: GO:0098706
name: ferric iron import across plasma membrane
namespace: biological_process
def: "The directed movement of ferric iron ions (Fe(III) or Fe3+) from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]
is_a: GO:0097461 ! ferric iron import into cell
is_a: GO:0098711 ! iron ion import across plasma membrane

[Term]
id: GO:0098707
name: ferrous iron import across plasma membrane
namespace: biological_process
def: "The directed movement of ferrous iron ions (Fe(II) or Fe2+) from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]
is_a: GO:0097460 ! ferrous iron import into cell
is_a: GO:0098711 ! iron ion import across plasma membrane
is_a: GO:1903874 ! ferrous iron transmembrane transport

[Term]
id: GO:0098708
name: glucose import across plasma membrane
namespace: biological_process
def: "The directed movement of glucose from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]
is_a: GO:0061490 ! glucose import into cell
is_a: GO:0098704 ! carbohydrate import across plasma membrane
is_a: GO:1904659 ! glucose transmembrane transport

[Term]
id: GO:0098709
name: glutathione import across plasma membrane
namespace: biological_process
def: "The directed movement of glutathione from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]
is_a: GO:0034775 ! glutathione transmembrane transport
is_a: GO:0036347 ! glutathione import into cell
is_a: GO:0098739 ! import across plasma membrane

[Term]
id: GO:0098710
name: guanine import across plasma membrane
namespace: biological_process
def: "The directed movement of guanine from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]
is_a: GO:0061489 ! guanine import into cell
is_a: GO:0098739 ! import across plasma membrane
is_a: GO:1903716 ! guanine transmembrane transport

[Term]
id: GO:0098711
name: iron ion import across plasma membrane
namespace: biological_process
def: "The directed movement of iron ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]
is_a: GO:0034755 ! iron ion transmembrane transport
is_a: GO:0097459 ! iron ion import into cell
is_a: GO:0098739 ! import across plasma membrane

[Term]
id: GO:0098712
name: L-glutamate import across plasma membrane
namespace: biological_process
def: "The directed movement of L-glutamate from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]
is_a: GO:0089711 ! L-glutamate transmembrane transport
is_a: GO:0089718 ! amino acid import across plasma membrane
is_a: GO:1990123 ! L-glutamate import into cell

[Term]
id: GO:0098713
name: leucine import across plasma membrane
namespace: biological_process
def: "The directed movement of leucine from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]
is_a: GO:0089718 ! amino acid import across plasma membrane
is_a: GO:0098655 ! cation transmembrane transport
is_a: GO:1990122 ! leucine import into cell

[Term]
id: GO:0098714
name: malate import across plasma membrane
namespace: biological_process
def: "The directed movement of malate from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]
is_a: GO:0071423 ! malate transmembrane transport
is_a: GO:0097405 ! malate import into cell
is_a: GO:0098739 ! import across plasma membrane

[Term]
id: GO:0098715
name: malonic acid import across plasma membrane
namespace: biological_process
def: "The directed movement of malonic acid from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]
is_a: GO:0097406 ! malonic acid import into cell
is_a: GO:0098739 ! import across plasma membrane
is_a: GO:1901553 ! malonic acid transmembrane transport

[Term]
id: GO:0098716
name: nickel cation import across plasma membrane
namespace: biological_process
def: "The directed movement of nickel cations from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]
is_a: GO:0090509 ! nickel cation import into cell
is_a: GO:0098659 ! inorganic cation import into cell
is_a: GO:0098739 ! import across plasma membrane

[Term]
id: GO:0098717
name: pantothenate import across plasma membrane
namespace: biological_process
def: "The directed movement of pantothenate from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]
is_a: GO:0015887 ! pantothenate transmembrane transport
is_a: GO:0044755 ! pantothenate import into cell
is_a: GO:0098739 ! import across plasma membrane

[Term]
id: GO:0098718
name: serine import across plasma membrane
namespace: biological_process
def: "The directed movement of serine from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]
is_a: GO:0061491 ! serine import into cell
is_a: GO:0089718 ! amino acid import across plasma membrane
is_a: GO:0098655 ! cation transmembrane transport

[Term]
id: GO:0098719
name: sodium ion import across plasma membrane
namespace: biological_process
def: "The directed movement of sodium ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]
is_a: GO:0098659 ! inorganic cation import into cell
is_a: GO:0098739 ! import across plasma membrane
is_a: GO:1990118 ! sodium ion import into cell

[Term]
id: GO:0098720
name: succinate import across plasma membrane
namespace: biological_process
def: "The directed movement of succinate from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]
is_a: GO:0071422 ! succinate transmembrane transport
is_a: GO:0097404 ! succinate import into cell
is_a: GO:0098739 ! import across plasma membrane

[Term]
id: GO:0098721
name: uracil import across plasma membrane
namespace: biological_process
def: "The directed movement of uracil from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]
is_a: GO:0098739 ! import across plasma membrane
is_a: GO:1902431 ! uracil import into cell
is_a: GO:1903791 ! uracil transmembrane transport

[Term]
id: GO:0098722
name: asymmetric stem cell division
namespace: biological_process
def: "Division of a stem cell during which it retains its identity and buds off a daughter cell with a new identity." [GOC:dos, PMID:18513950]
is_a: GO:0008356 ! asymmetric cell division
is_a: GO:0017145 ! stem cell division

[Term]
id: GO:0098723
name: skeletal muscle myofibril
namespace: cellular_component
def: "A myofibril of a skeletal muscle fiber." [GOC:dos]
is_a: GO:0030016 ! myofibril

[Term]
id: GO:0098724
name: symmetric stem cell division
namespace: biological_process
def: "Symmetric division of a stem cell to produce two stem cells of the same type as the parent. Symmetric stem cell division is necessary for amplification of stem cell populations in the absence of sources of stem cells external to an existing population." [PMID:19948499, PMID:23303905]
comment: Examples include the self-renewal of spermatogonial stem cells and (some) division during amplification of skeletal muscle satellite cell populations.
is_a: GO:0017145 ! stem cell division
is_a: GO:0098725 ! symmetric cell division

[Term]
id: GO:0098725
name: symmetric cell division
namespace: biological_process
def: "Cell division in which both daughter cells are of the same type." [GOC:dos]
is_a: GO:0051301 ! cell division

[Term]
id: GO:0098726
name: symmetric division of skeletal muscle satellite stem cell
namespace: biological_process
def: "The symmetric division of a skeletal muscle satellite stem cell, resulting in two skeletal muscle satellite stem cells.  This process is involved in amplification of the pool of these cells." [PMID:23303905]
is_a: GO:0098724 ! symmetric stem cell division

[Term]
id: GO:0098727
name: maintenance of cell number
namespace: biological_process
def: "Any process by which the numbers of cells of a particular type in a tissue are maintained." [GOC:dos]
is_a: GO:0032502 ! developmental process

[Term]
id: GO:0098728
name: germline stem cell asymmetric division
namespace: biological_process
def: "The self-renewing division of a germline stem cell, to produce a daughter stem cell and a daughter germ cell which will divide to form one or more gametes." [GOC:dos]
is_a: GO:0042078 ! germ-line stem cell division
is_a: GO:0098722 ! asymmetric stem cell division

[Term]
id: GO:0098729
name: germline stem cell symmetric division
namespace: biological_process
def: "Division of a germline stem cell to produce two germline stem cells of the same type as the parent." [GOC:dos, PMID:19948499]
is_a: GO:0042078 ! germ-line stem cell division
is_a: GO:0098724 ! symmetric stem cell division

[Term]
id: GO:0098730
name: male germline stem cell symmetric division
namespace: biological_process
def: "The symmetric division of a male germline stem cell to produce two male germline stem cells.  An example of this is found in mammalian spermatogonial stem cells, some proportion of which divide symmetrically, so amplifying the population. The choice between asymmetric and symmetric division in this case appears to be internal and stochastic." [GOC:dos, PMID:19948499]
is_a: GO:0098729 ! germline stem cell symmetric division

[Term]
id: GO:0098731
name: skeletal muscle satellite stem cell maintenance involved in skeletal muscle regeneration
namespace: biological_process
def: "Any process by which the number of skeletal muscle satellite stem cells in a skeletal muscle is maintained during skeletal muscle regeneration. There are at least two mechanisms by which this is achieved. Skeletal muscle satellite stem cell asymmetric division ensures satellite stem cell numbers are kept constant. Symmetric division of these cells amplifies the number of skeletal muscle satellite stem cells." [PMID:23303905]
is_a: GO:0014834 ! skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
is_a: GO:0035019 ! somatic stem cell population maintenance
relationship: part_of GO:0043403 ! skeletal muscle tissue regeneration

[Term]
id: GO:0098732
name: macromolecule deacylation
namespace: biological_process
def: "The removal of an acyl group, any group or radical of the form RCO- where R is an organic group, from a macromolecule." [GOC:dos]
is_a: GO:0043412 ! macromolecule modification

[Term]
id: GO:0098733
name: hemidesmosome associated protein complex
namespace: cellular_component
def: "Any protein complex that is part of or has some part in a hemidesmosome." [GOC:dos]
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0098734
name: macromolecule depalmitoylation
namespace: biological_process
def: "The removal of palymitoyl groups from a macromolecule." [GOC:dos]
is_a: GO:0098732 ! macromolecule deacylation

[Term]
id: GO:0098735
name: positive regulation of the force of heart contraction
namespace: biological_process
def: "Any process that increases the force of heart muscle contraction." [GOC:BHF, GOC:dos, GOC:mtg_cardiac_conduct_nov11, GOC:rl, PMID:17242280]
is_a: GO:0002026 ! regulation of the force of heart contraction

[Term]
id: GO:0098736
name: negative regulation of the force of heart contraction
namespace: biological_process
def: "Any process that decreases the force of heart muscle contraction." [GOC:BHF, GOC:dos, GOC:mtg_cardiac_conduct_nov11, GOC:rl, PMID:17242280]
is_a: GO:0002026 ! regulation of the force of heart contraction

[Term]
id: GO:0098737
name: protein insertion into plasma membrane
namespace: biological_process
def: "The process that results in the incorporation of a protein into a plasma membrane.  Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers." [GOC:DOS]
is_a: GO:0051205 ! protein insertion into membrane
is_a: GO:0090002 ! establishment of protein localization to plasma membrane

[Term]
id: GO:0098739
name: import across plasma membrane
namespace: biological_process
def: "The directed movement of some substance from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]
is_a: GO:0055085 ! transmembrane transport
is_a: GO:0098657 ! import into cell

[Term]
id: GO:0098740
name: multi organism cell adhesion
namespace: biological_process
def: "Cell adhesion that involves cells from multiple organisms or that is mediated by gene products from multiple organisms." [GOC:dos]
is_a: GO:0007155 ! cell adhesion
is_a: GO:0051704 ! multi-organism process

[Term]
id: GO:0098741
name: adhesion between unicellular organisms via cell-wall interaction
namespace: biological_process
def: "The attachment of two unicellular organisms to each other via interaction between cell-wall components." [GOC:dos]
is_a: GO:0098610 ! adhesion between unicellular organisms

[Term]
id: GO:0098742
name: cell-cell adhesion via plasma-membrane adhesion molecules
namespace: biological_process
def: "The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane." [GOC:dos]
is_a: GO:0098609 ! cell-cell adhesion

[Term]
id: GO:0098743
name: cell aggregation
namespace: biological_process
def: "The clustering together and adhesion of initially separate cells to form an aggregate.  Examples include the clustering of unicellular organisms or blood cells in suspension and the condensation of mesenchymal cells during cartilage formation." [GOC:dos]
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0098744
name: 1-phosphatidylinositol 4-kinase activator activity
namespace: molecular_function
def: "Binds to and increases the activity of 1-phosphatidylinositol 4-kinase." [PMID:21288895]
is_a: GO:0019209 ! kinase activator activity

[Term]
id: GO:0098745
name: Dcp1-Dcp2 complex
namespace: cellular_component
def: "A protein complex consisting of a Dcp1 regulatory subunit and a Dcp2 catalytic subunit that has mRNA cap binding activity and is involved in decapping of nuclear-transcribed mRNA." [GOC:dos, GOC:vw, PMID:22323607]
comment: Additional components may be present, for example in ascomycetes this complex includes an additional regulatory subunit, Edc1.
is_a: GO:0005845 ! mRNA cap binding complex

[Term]
id: GO:0098746
name: fast, calcium ion-dependent exocytosis of neurotransmitter
namespace: biological_process
def: "The fast, initial phase of calcium ion-induced neurotransmitter release, via exocytosis, into the synaptic cleft. This depends on low affinity calcium sensors and typically begins a fraction of a millisecond after Ca2+ influx, and decays rapidly (1-10ms) with a decay constant of around 5-10ms. The underlying molecular mechanisms of this process are distinct from those of the later, slow phase of release." [GOC:dos, GOC:pad, GOC:PARL, PMID:4405553, PMID:7809151, PMID:7954835]
subset: goslim_synapse
synonym: "synchronous, calcium ion-dependent exocytosis of neurotransmitter" EXACT [PMID:7954835]
is_a: GO:0048791 ! calcium ion-regulated exocytosis of neurotransmitter

[Term]
id: GO:0098747
name: slow, calcium ion-dependent exocytosis of neurotransmitter
namespace: biological_process
def: "The slow, second phase of calcium ion-induced neurotransmitter release, via exocytosis, into the synaptic cleft. This depends on high affinity calcium sensors and decays slowly, typically with a decay constant of over 100ms. The underlying molecular mechanisms of this process are distinct from those of the earlier, fast phase of release." [GOC:dos, GOC:pad, GOC:parl, PMID:7809151, PMID:7954835]
subset: goslim_synapse
is_a: GO:0048791 ! calcium ion-regulated exocytosis of neurotransmitter

[Term]
id: GO:0098748
name: endocytic adaptor activity
namespace: molecular_function
def: "The binding activity of a molecule that brings together two or more protein molecules, or a protein and another macromolecule or complex as a key step in receptor mediated endocytosis." [GOC:dos, GOC:vw, PMID:21536832]
is_a: GO:0030674 ! protein binding, bridging
relationship: part_of GO:0006898 ! receptor-mediated endocytosis

[Term]
id: GO:0098749
name: cerebellar neuron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cerebellar neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dos]
is_a: GO:0021954 ! central nervous system neuron development
relationship: part_of GO:0021549 ! cerebellum development

[Term]
id: GO:0098750
name: FYXD domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a FXYD domain." [GOC:dos, GOC:mr, PMID:10950925, PMID:16403837, PMID:18000745]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0098751
name: bone cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a bone cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dos]
comment: Not to be used for manual annotation.  Please choose a more specific cell development term or if not possible, bone or bone tissue development.
subset: gocheck_do_not_annotate
is_a: GO:0048468 ! cell development
relationship: part_of GO:0060348 ! bone development

[Term]
id: GO:0098752
name: integral component of the cytoplasmic side of the plasma membrane
namespace: cellular_component
def: "The component of the plasma membrane consisting of the gene products that penetrate only the cytoplasmic side of the membrane." [GOC:dos]
is_a: GO:0005887 ! integral component of plasma membrane
is_a: GO:0031235 ! intrinsic component of the cytoplasmic side of the plasma membrane
intersection_of: GO:0016021 ! integral component of membrane
intersection_of: part_of GO:0009898 ! cytoplasmic side of plasma membrane
relationship: part_of GO:0009898 ! cytoplasmic side of plasma membrane

[Term]
id: GO:0098753
name: anchored component of the cytoplasmic side of the plasma membrane
namespace: cellular_component
def: "The component of the plasma membrane consisting of gene products and protein complexes with covalently attached hydrophobic anchors products that penetrate only the cytoplasmic side of the membrane." [GOC:dos]
comment: Examples include many myristoylated proteins.
is_a: GO:0031235 ! intrinsic component of the cytoplasmic side of the plasma membrane
is_a: GO:0046658 ! anchored component of plasma membrane
intersection_of: GO:0031225 ! anchored component of membrane
intersection_of: part_of GO:0009898 ! cytoplasmic side of plasma membrane
relationship: part_of GO:0009898 ! cytoplasmic side of plasma membrane

[Term]
id: GO:0098754
name: detoxification
namespace: biological_process
def: "Any process that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance." [GOC:dos]
subset: goslim_pombe
is_a: GO:0008150 ! biological_process
relationship: part_of GO:0009636 ! response to toxic substance

[Term]
id: GO:0098755
name: maintenance of seed dormancy by absisic acid
namespace: biological_process
def: "The process by which seed dormancy is maintained by the presence of absisic acid." [GOC:dos, PMID:9580097]
is_a: GO:0010231 ! maintenance of seed dormancy
intersection_of: GO:0010231 ! maintenance of seed dormancy
intersection_of: part_of GO:0009737 ! response to abscisic acid
relationship: part_of GO:0009737 ! response to abscisic acid

[Term]
id: GO:0098756
name: response to interleukin-21
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-21 stimulus." [GOC:BHF, GOC:mah]
synonym: "response to IL-21" EXACT [GOC:mah]
is_a: GO:0034097 ! response to cytokine

[Term]
id: GO:0098757
name: cellular response to interleukin-21
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-21 stimulus." [GOC:BHF, GOC:mah]
synonym: "cellular response to IL-21" EXACT [GOC:mah]
is_a: GO:0098756 ! response to interleukin-21

[Term]
id: GO:0098758
name: response to interleukin-8
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-8 stimulus." [GOC:BHF, GOC:mah]
synonym: "response to IL-8" EXACT [GOC:mah]
is_a: GO:0034097 ! response to cytokine

[Term]
id: GO:0098759
name: cellular response to interleukin-8
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-8 stimulus." [GOC:BHF, GOC:mah]
synonym: "cellular response to IL-8" EXACT [GOC:mah]
is_a: GO:0071345 ! cellular response to cytokine stimulus
is_a: GO:0098758 ! response to interleukin-8

[Term]
id: GO:0098760
name: response to interleukin-7
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-7 stimulus." [GOC:BHF, GOC:mah]
synonym: "response to IL-7" EXACT [GOC:mah]
is_a: GO:0034097 ! response to cytokine

[Term]
id: GO:0098761
name: cellular response to interleukin-7
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-7 stimulus." [GOC:BHF, GOC:mah]
synonym: "cellular response to IL-7" EXACT [GOC:mah]
is_a: GO:0071345 ! cellular response to cytokine stimulus
is_a: GO:0098760 ! response to interleukin-7

[Term]
id: GO:0098762
name: meiotic cell cycle phase
namespace: biological_process
def: "One of the distinct periods or stages into which the meiotic cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events." [GOC:dos]
comment: This term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation should be to 'regulation of x/y phase transition' or to a process which occurs during the reported phase (e.g. mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0022403 ! cell cycle phase
intersection_of: GO:0022403 ! cell cycle phase
intersection_of: happens_during GO:0051321 ! meiotic cell cycle
relationship: happens_during GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0098763
name: mitotic cell cycle phase
namespace: biological_process
def: "One of the distinct periods or stages into which the mitotic cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events." [GOC:dos]
comment: This term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation should be to 'regulation of x/y phase transition' or to a process which occurs during the reported phase (e.g. mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0022403 ! cell cycle phase
intersection_of: GO:0022403 ! cell cycle phase
intersection_of: happens_during GO:0000278 ! mitotic cell cycle
relationship: happens_during GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0098764
name: meiosis I cell cycle phase
namespace: biological_process
def: "A meiotic cell cycle phase prior to a during which some part of meiosis I nuclear division or the proceeding cytokinesis occurs." [GOC:dos]
comment: This term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation should be to 'regulation of x/y phase transition' or to a process which occurs during the reported phase (e.g. mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0098762 ! meiotic cell cycle phase

[Term]
id: GO:0098765
name: meiosis II cell cycle phase
namespace: biological_process
def: "A meiotic cell cycle phase that occurs after meiosis I (the first meiotic nuclear division)." [GOC:dos]
comment: This term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation should be to 'regulation of x/y phase transition' or to a process which occurs during the reported phase (e.g. mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0098762 ! meiotic cell cycle phase

[Term]
id: GO:0098766
name: obsolete meiosis I M phase
namespace: biological_process
def: "M phase during meiosis I." [GOC:dos]
comment: Obsoleted because added in error.
is_obsolete: true
consider: GO:0098762

[Term]
id: GO:0098767
name: obsolete meiosis II M phase
namespace: biological_process
def: "M phase during meiosis II" [GOC:dos]
comment: Obsoleted because added in error.
is_obsolete: true
consider: GO:0098762

[Term]
id: GO:0098768
name: meiotic prometaphase I
namespace: biological_process
def: "The meiotic cell cycle phase in eukaryotes between meiotic prophase I and meiotic metaphase I. During meiotic prometaphase I, the nuclear envelope breaks down and one kinetochore forms per chromosome. Chromosomes attach to spindle microtubules and begin to move towards the metaphase plate." [PMID:16012859]
comment: This term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation should be to 'regulation of x/y phase transition' or to a process which occurs during the reported phase (e.g. mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0098764 ! meiosis I cell cycle phase

[Term]
id: GO:0098769
name: TIMP family protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any member of the Tissue inhibitors of metalloproteinases (TIMPs) family. TIMPs are endogenous protein regulators of the matrix metalloproteinase (MMPs) family" [PMID:22078297]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0098770
name: FBXO family protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any member of the FBXO protein family. Members of this family have an F-box protein motif of approximately 50 amino acids that functions as a site of protein-protein interaction." [PMID:11178263]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0098771
name: inorganic ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of inorganic ions within an organism or cell." [GOC:dos]
is_a: GO:0050801 ! ion homeostasis

[Term]
id: GO:0098772
name: molecular function regulator
namespace: molecular_function
def: "A molecular function that modulates the activity of a gene product or complex.  Examples include enzyme regulators and channel regulators." [GOC:dos, GOC:pt]
is_a: GO:0003674 ! molecular_function
intersection_of: GO:0003674 ! molecular_function
intersection_of: regulates GO:0003674 ! molecular_function
relationship: regulates GO:0003674 ! molecular_function

[Term]
id: GO:0098773
name: skin epidermis development
namespace: biological_process
def: "The process whose specific outcome is the progression of the skin epidermis over time, from its formation to the mature structure." [GOC:dos]
is_a: GO:0008544 ! epidermis development
relationship: part_of GO:0043588 ! skin development

[Term]
id: GO:0098774
name: curli
namespace: cellular_component
def: "A proteinaceous extracellular fiber, produced by an enteric bacterium, that is involved in surface and cell-cell contacts that promote community behavior and host colonization." [PMID:16704339]
synonym: "tafi" NARROW [PMID:16704339]
synonym: "thin aggregative fimbrae" NARROW [PMID:16704339]
is_a: GO:0032991 ! macromolecular complex
is_a: GO:0097312 ! biofilm matrix component
relationship: part_of GO:0097311 ! biofilm matrix

[Term]
id: GO:0098775
name: curli assembly
namespace: biological_process
def: "The process of assembly of curli, extracellular fibers produced by enteric bacteria.  This process occurs outside the cell, where it is coupled to secretion across the cell outer membrane via nucleation by elements of the transporter complex." [PMID:16704339]
is_a: GO:0065003 ! macromolecular complex assembly
is_a: GO:0098785 ! biofilm matrix assembly

[Term]
id: GO:0098776
name: protein transport across the cell outer membrane
namespace: biological_process
def: "The directed movement of proteins across the cell outer membrane." [GOC:dos]
is_a: GO:0071806 ! protein transmembrane transport

[Term]
id: GO:0098777
name: protein secretion by the type VIII secretion system
namespace: biological_process
def: "Protein secretion through the outer membrane via the mechanism used for the secretion of curli subunits." [PMID:19299134, PMID:24080089]
comment: This term is defined so as to leave open the possibility that things other than curli subunits are secreted via same secretory system as that used by curli subunits.
synonym: "T8SS" EXACT [PMID:19299134]
is_a: GO:0098776 ! protein transport across the cell outer membrane

[Term]
id: GO:0098778
name: curli subunit secretion coupled to curli assembly
namespace: biological_process
def: "The secretion of soluble curli subunits through the outer membrane, coupled to nucleation of curli fiber formation at the membrane surface." [PMID:24080089]
synonym: "extracellular nucleation-precipitation pathway" EXACT [PMID:19299134]
is_a: GO:0098777 ! protein secretion by the type VIII secretion system

[Term]
id: GO:0098779
name: mitophagy in response to mitochondrial depolarization
namespace: biological_process
def: "The macromitophagy process that is triggered by a detection of the loss of mitochondrial membrane potential." [GOC:PARL, PMID:18200046, PMID:23985961]
is_a: GO:0000423 ! macromitophagy
relationship: part_of GO:0098780 ! response to mitochondrial depolarisation

[Term]
id: GO:0098780
name: response to mitochondrial depolarisation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) in response to the depolarization of one or more mitochondria." [GOC:dos]
is_a: GO:0033554 ! cellular response to stress

[Term]
id: GO:0098781
name: ncRNA transcription
namespace: biological_process
def: "The transcription of non (protein) coding RNA from a DNA template." [GOC:dos]
is_a: GO:0006351 ! transcription, DNA-templated
is_a: GO:0034660 ! ncRNA metabolic process

[Term]
id: GO:0098782
name: mechanically-gated potassium channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a potassium ion by a channel that opens in response to a mechanical stress." [PMID:22282805, PMID:25471887, PMID:25500157]
is_a: GO:0005267 ! potassium channel activity
is_a: GO:0008381 ! mechanically-gated ion channel activity

[Term]
id: GO:0098783
name: correction of merotelic kinetochore attachment, mitotic
namespace: biological_process
def: "The cell cycle process that corrects the anomalous association of a single chromatid kinetochore with mitotic spindle microtubules emanating from both spindle poles (otherwise known as merotelic attachment to the spindle)." [PMID:21306900]
is_a: GO:1902423 ! regulation of mitotic attachment of spindle microtubules to kinetochore
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:0000070 ! mitotic sister chromatid segregation
relationship: regulates GO:0051315 ! attachment of mitotic spindle microtubules to kinetochore

[Term]
id: GO:0098784
name: biofilm matrix organization
namespace: biological_process
def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of a biofilm matrix." [GOC:mah]
subset: gosubset_prok
synonym: "biofilm matrix organization and biogenesis" RELATED [GOC:dos]
is_a: GO:0030198 ! extracellular matrix organization

[Term]
id: GO:0098785
name: biofilm matrix assembly
namespace: biological_process
def: "A process that results in the assembly of a biofilm matrix." [GOC:mah]
is_a: GO:0085029 ! extracellular matrix assembly
is_a: GO:0098784 ! biofilm matrix organization
relationship: part_of GO:0042710 ! biofilm formation

[Term]
id: GO:0098786
name: biofilm matrix disassembly
namespace: biological_process
def: "A process that results in the disassembly of a biofilm matrix." [GOC:mah]
is_a: GO:0022617 ! extracellular matrix disassembly
is_a: GO:0098784 ! biofilm matrix organization

[Term]
id: GO:0098787
name: mRNA cleavage involved in mRNA processing
namespace: biological_process
def: "Cleavage of an immature mRNA transcript to produce one or more more mature mRNA transcripts, prior to translation into polypeptide." [GOC:dos]
is_a: GO:0006379 ! mRNA cleavage
intersection_of: GO:0006379 ! mRNA cleavage
intersection_of: part_of GO:0006397 ! mRNA processing
relationship: part_of GO:0006397 ! mRNA processing

[Term]
id: GO:0098788
name: dendritic knob
namespace: cellular_component
def: "The terminal swelling of an apical dendrite of an olfactory receptor neuron. Each knob gives rise to 5 to 20 long delicate nonmotile cilia, which extend into the mucus covering the sensory epithelium" [PMID:20801626]
synonym: "apical dendritic knob" EXACT []
is_a: GO:0044292 ! dendrite terminus

[Term]
id: GO:0098789
name: pre-mRNA cleavage required for polyadenylation
namespace: biological_process
def: "The targeted, endonucleolytic cleavage of a pre-mRNA,  required for polyadenylation of the 3' end.  This cleavage is directed by binding sites near the 3' end of the mRNA and leaves a 3' hydoxyl end which then becomes a target for adenylation." [http://www.ncbi.nlm.nih.gov/books/NBK21563/#_A2878_]
synonym: "cleavage and polyadenylylation specificity factor activity" RELATED []
synonym: "pre-mRNA cleavage factor activity" EXACT []
is_a: GO:0098787 ! mRNA cleavage involved in mRNA processing
relationship: has_part GO:0004521 ! endoribonuclease activity
relationship: part_of GO:0031124 ! mRNA 3'-end processing

[Term]
id: GO:0098790
name: ncRNA transcription associated with protein coding gene TSS/TES
namespace: biological_process
def: "The transcription of non-coding RNA associated with transcriptional start and end sites of protein coding genes. This occurs at some low level for many protein coding genes." [PMID:20502517]
synonym: "pasRNA transcription" NARROW [PMID:20502517]
is_a: GO:0098781 ! ncRNA transcription

[Term]
id: GO:0098791
name: Golgi subcompartment
namespace: cellular_component
def: "A compartment that consists of a lumen and an enclosing membrane, and is part of the Golgi Apparatus." [GOC:dos]
is_a: GO:0031984 ! organelle subcompartment
is_a: GO:0044431 ! Golgi apparatus part
intersection_of: GO:0031984 ! organelle subcompartment
intersection_of: part_of GO:0005794 ! Golgi apparatus
relationship: part_of GO:0005794 ! Golgi apparatus

[Term]
id: GO:0098792
name: xenophagy
namespace: biological_process
def: "The macroautophagy process in which a region of cytoplasm containing an intracellular pathogen or some part of an intracellular pathogen (e.g. viral capsid) is enclosed in a double membrane bound autophagosome, which then fuses with the lysosome leading to degradation of the contents." [GOC:autophagy, GOC:pad, GOC:PARL, PMID:19802565, PMID:20159618, PMID:25497060]
comment: While making xenophagy a subclass of (macro)autophagy may seem to directly contradict the definition of autophagy (literally self eating), it is clear that the same pathway is involved as in macroautophagy that doesn't target foreign material: formation of double-membrane-bounded autophagosomes that enclose a region of cytoplasm for degradation.
is_a: GO:0016236 ! macroautophagy
relationship: part_of GO:0098542 ! defense response to other organism

[Term]
id: GO:0098793
name: presynapse
namespace: cellular_component
def: "The part of a synapse that is part of the presynaptic cell." [GOC:dos]
subset: goslim_synapse
is_a: GO:0044456 ! synapse part
is_a: GO:0097458 ! neuron part
relationship: part_of GO:0045202 ! synapse

[Term]
id: GO:0098794
name: postsynapse
namespace: cellular_component
def: "The part of a synapse that is part of the post-synaptic cell." [GOC:dos]
subset: goslim_synapse
is_a: GO:0044456 ! synapse part
is_a: GO:0044464 ! cell part
relationship: part_of GO:0045202 ! synapse

[Term]
id: GO:0098795
name: mRNA cleavage involved in gene silencing
namespace: biological_process
def: "Cleavage of an mRNA occurring as part of the mechanism of gene silencing." [GOC:BHF_miRNA, GOC:dos]
is_a: GO:0006379 ! mRNA cleavage
intersection_of: GO:0006379 ! mRNA cleavage
intersection_of: part_of GO:0016458 ! gene silencing
relationship: part_of GO:0016458 ! gene silencing

[Term]
id: GO:0098796
name: membrane protein complex
namespace: cellular_component
def: "Any protein complex that is part of a membrane." [GOC:dos]
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
intersection_of: GO:0043234 ! protein complex
intersection_of: part_of GO:0016020 ! membrane
relationship: part_of GO:0016020 ! membrane

[Term]
id: GO:0098797
name: plasma membrane protein complex
namespace: cellular_component
def: "Any protein complex that is part of the plasma membrane." [GOC:dos]
is_a: GO:0044459 ! plasma membrane part
is_a: GO:0098796 ! membrane protein complex
intersection_of: GO:0043234 ! protein complex
intersection_of: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0005886 ! plasma membrane

[Term]
id: GO:0098798
name: mitochondrial protein complex
namespace: cellular_component
def: "A protein complex that is part of a mitochondrion." [GOC:dos]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
is_a: GO:0043234 ! protein complex
is_a: GO:0044429 ! mitochondrial part
intersection_of: GO:0043234 ! protein complex
intersection_of: part_of GO:0005739 ! mitochondrion
relationship: part_of GO:0005739 ! mitochondrion

[Term]
id: GO:0098799
name: outer mitochondrial membrane protein complex
namespace: cellular_component
def: "Any protein complex that is part of the outer mitochondrial membrane." [GOC:dos]
is_a: GO:0044455 ! mitochondrial membrane part
is_a: GO:0098796 ! membrane protein complex
is_a: GO:0098798 ! mitochondrial protein complex
intersection_of: GO:0043234 ! protein complex
intersection_of: part_of GO:0005741 ! mitochondrial outer membrane
relationship: part_of GO:0005741 ! mitochondrial outer membrane

[Term]
id: GO:0098800
name: inner mitochondrial membrane protein complex
namespace: cellular_component
def: "Any protein complex that is part of the inner mitochondrial membrane." [GOC:dos]
is_a: GO:0044455 ! mitochondrial membrane part
is_a: GO:0098796 ! membrane protein complex
is_a: GO:0098798 ! mitochondrial protein complex
intersection_of: GO:0043234 ! protein complex
intersection_of: part_of GO:0005743 ! mitochondrial inner membrane
relationship: part_of GO:0005743 ! mitochondrial inner membrane

[Term]
id: GO:0098801
name: regulation of renal system process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by the renal system." [GOC:dos]
is_a: GO:0044057 ! regulation of system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003014 ! renal system process
relationship: regulates GO:0003014 ! renal system process

[Term]
id: GO:0098802
name: plasma membrane receptor complex
namespace: cellular_component
def: "Any protein complex that is part of the plasma membrane and which functions as a receptor." [GOC:dos]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
is_a: GO:0043235 ! receptor complex
is_a: GO:0098797 ! plasma membrane protein complex
relationship: part_of GO:0005886 ! plasma membrane

[Term]
id: GO:0098803
name: respiratory chain complex
namespace: cellular_component
def: "Any protein complex that is part of a respiratory chain" [GOC:dos]
is_a: GO:0098796 ! membrane protein complex
intersection_of: GO:0043234 ! protein complex
intersection_of: part_of GO:0070469 ! respiratory chain
relationship: part_of GO:0070469 ! respiratory chain

[Term]
id: GO:0098804
name: nonmotile primary cilium membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a non-motile primary cilium." [GOC:dos]
is_a: GO:0060170 ! ciliary membrane

[Term]
id: GO:0098805
name: whole membrane
namespace: cellular_component
def: "Any lipid bilayer that completely encloses some structure, and all the proteins embedded in it or attached to it.  Examples include the plasma membrane and most organelle membranes." [GOC:dos]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:0016020 ! membrane

[Term]
id: GO:0098806
name: deadenylation involved in gene silencing by miRNA
namespace: biological_process
def: "Shortening of the poly(A) tail of a nuclear-transcribed mRNA following miRNA binding to mRNA, resulting in destabilization of the mRNA and a reduction in the efficiency of its translation." [GOC:bhf, GOC:dos, PMID:21118121, PMID:23209154]
is_a: GO:0000289 ! nuclear-transcribed mRNA poly(A) tail shortening
intersection_of: GO:0000289 ! nuclear-transcribed mRNA poly(A) tail shortening
intersection_of: part_of GO:0035195 ! gene silencing by miRNA
relationship: part_of GO:0035195 ! gene silencing by miRNA

[Term]
id: GO:0098807
name: chloroplast thylakoid membrane protein complex
namespace: cellular_component
def: "A protein complex that is part of a chloroplast thylakoid membrane." [GOC:dos]
is_a: GO:0044434 ! chloroplast part
is_a: GO:0044436 ! thylakoid part
is_a: GO:0098796 ! membrane protein complex
intersection_of: GO:0043234 ! protein complex
intersection_of: part_of GO:0009535 ! chloroplast thylakoid membrane
relationship: part_of GO:0009535 ! chloroplast thylakoid membrane

[Term]
id: GO:0098808
name: mRNA cap binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule." [GOC:dos]
is_a: GO:0000339 ! RNA cap binding

[Term]
id: GO:0098809
name: nitrite reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: nitrite + acceptor = product(s) of nitrate reduction + reduced acceptor." [GOC:dos, GOC:jh]
is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors

[Term]
id: GO:0098810
name: neurotransmitter reuptake
namespace: biological_process
def: "The directed movement of neurotransmitter molecules from the extrasynaptic space into the presynaptic cytosol." [GOC:dos]
subset: goslim_synapse
is_a: GO:0001504 ! neurotransmitter uptake
is_a: GO:0051649 ! establishment of localization in cell
relationship: occurs_in GO:0098793 ! presynapse

[Term]
id: GO:0098811
name: transcriptional repressor activity, RNA polymerase II activating transcription factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase II activating transcription factor and also with the RNA polymerase II basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription." [GOC:BHF, GOC:dos, GOC:rl, GOC:txnOH]
synonym: "RNA polymerase II activating transcription factor binding transcription factor activity involved in negative regulation of transcription" EXACT []
synonym: "RNA polymerase II activating transcription factor binding transcription repressor activity" EXACT []
synonym: "RNA polymerase II transcription repressor activity" BROAD []
is_a: GO:0001191 ! transcriptional repressor activity, RNA polymerase II transcription factor binding
intersection_of: GO:0000988 ! transcription factor activity, protein binding
intersection_of: has_part GO:0001102 ! RNA polymerase II activating transcription factor binding
intersection_of: part_of GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
relationship: has_part GO:0001102 ! RNA polymerase II activating transcription factor binding
relationship: part_of GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
created_by: kchris
creation_date: 2011-08-25T02:12:30Z

[Term]
id: GO:0098812
name: nuclear rRNA polyadenylation involved in polyadenylation-dependent rRNA catabolic process
namespace: biological_process
def: "The enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end of a rRNA, occurring as part of the process of polyadenylation-dependent rRNA catabolism in the nucleus." [GOC:dph, GOC:jl, GOC:tb]
synonym: "nuclear rRNA polyadenylation during polyadenylation-dependent rRNA catabolic process" RELATED [GOC:dph, GOC:tb]
synonym: "nuclear rRNA polyadenylation involved in poly(A)-dependent rRNA catabolic process" RELATED [GOC:vw]
is_a: GO:0043630 ! ncRNA polyadenylation involved in polyadenylation-dependent ncRNA catabolic process
relationship: part_of GO:0071035 ! nuclear polyadenylation-dependent rRNA catabolic process

[Term]
id: GO:0098813
name: nuclear chromosome segregation
namespace: biological_process
def: "The process in which genetic material, in the form of nuclear chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. Nuclear chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:dos]
is_a: GO:0007059 ! chromosome segregation
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0007049 ! cell cycle

[Term]
id: GO:0098814
name: spontaneous synaptic transmission
namespace: biological_process
def: "The low level of synaptic transmission that occurs via spontaneous neurotransmitter release into the synaptic cleft in the absence of a presynaptic action potential." [PMID:20200227]
comment: This is typically measured via detection of mini excitatory post-synaptic currents (mEPSCs).
subset: goslim_synapse
synonym: "basal synaptic transmission" EXACT [PMID:16899074]
is_a: GO:0007268 ! synaptic transmission
intersection_of: GO:0007268 ! synaptic transmission
intersection_of: has_part GO:0061669 ! spontaneous neurotransmitter secretion
relationship: has_part GO:0061669 ! spontaneous neurotransmitter secretion

[Term]
id: GO:0098815
name: modulation of excitatory postsynaptic potential
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of excitatory postsynaptic potential (EPSP). EPSP is a process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." [GOC:dos]
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0042391 ! regulation of membrane potential
is_a: GO:0050804 ! modulation of synaptic transmission
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: regulates GO:0060079 ! excitatory postsynaptic potential
relationship: regulates GO:0060079 ! excitatory postsynaptic potential

[Term]
id: GO:0098816
name: mini excitatory postsynaptic potential
namespace: biological_process
def: "A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell, induced by the spontaneous release of a single vesicle of an excitatory neurotransmitter into the synapse." [GOC:dos]
is_a: GO:0060079 ! excitatory postsynaptic potential

[Term]
id: GO:0098817
name: evoked excitatory postsynaptic potential
namespace: biological_process
def: "A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell induced by the evoked release of many vesicles of excitatory neurotransmitter at the synapse." [GOC:dos]
is_a: GO:0060079 ! excitatory postsynaptic potential

[Term]
id: GO:0098818
name: hyperpolarization of postsynaptic membrane
namespace: biological_process
def: "A process that hyerpolarizes a postsynaptic membrane relative to its resting potential.  This has an inhibitory effect on the post-synaptic cell, moving the membrane potential away from the firing threshold." [GOC:dos]
is_a: GO:0060078 ! regulation of postsynaptic membrane potential

[Term]
id: GO:0098819
name: depolarization of postsynaptic membrane
namespace: biological_process
def: "A process that depolarizes a postsynaptic membrane relative to its resting potential.  This has an excitatory effect on the post-synaptic cell, moving the membrane potential towards the firing threshold." [GOC:dos]
is_a: GO:0060078 ! regulation of postsynaptic membrane potential

[Term]
id: GO:0098820
name: trans-synaptic protein complex
namespace: cellular_component
def: "A protein complex that spans the synaptic cleft and has parts in both the pre- and post-synaptic membranes." [PMID:20200227]
subset: goslim_synapse
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0098821
name: BMP receptor activity
namespace: molecular_function
def: "Combining with a member of the bone morphogenetic protein (BMP) family, and transmitting a signal across the plasma membrane to initiate a change in cell activity." [GOC:BHF, GOC:dos]
is_a: GO:0004675 ! transmembrane receptor protein serine/threonine kinase activity
relationship: part_of GO:0030509 ! BMP signaling pathway

[Term]
id: GO:0098822
name: peptidyl-cysteine modification to L-cysteine persulfide
namespace: biological_process
def: "The modification of peptidyl-cysteine to form peptidyl-L-cysteine persulfide." [PMID:11592406]
xref: RESID:AA0269
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0098823
name: peptidyl-cysteine modification to S-amindino-L-cysteine
namespace: biological_process
def: "The amidinylation of peptidyl-cysteine to form peptidyl-S-amidino-L-cysteine." [RESID:AA0335]
xref: RESID:AA0335
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0098824
name: petidyl-cysteine sulfation
namespace: biological_process
def: "The sulfation of peptidyl-cysteine to form S-sulfo-L-cysteine." [RESID:AA0171]
xref: RESID:AA0171
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0098825
name: peptidyl-histidine guanylation
namespace: biological_process
def: "The guanylylation of peptidyl-histidine to form (phospho-5'-guanosine)-L-histidine." [RESID:AA0325]
subset: gosubset_prok
xref: RESID:AA0325
is_a: GO:0018117 ! protein adenylylation
is_a: GO:0018202 ! peptidyl-histidine modification

[Term]
id: GO:0098826
name: endoplasmic reticulum tubular network membrane
namespace: cellular_component
def: "The membrane of the endoplasmic reticulum tubular network." [PMID:16469703]
is_a: GO:0005789 ! endoplasmic reticulum membrane

[Term]
id: GO:0098827
name: endoplasmic reticulum subcompartment
namespace: cellular_component
def: "A distinct  region of the endoplasmic reticulum" [GOC:dos]
is_a: GO:0031984 ! organelle subcompartment
is_a: GO:0044432 ! endoplasmic reticulum part
intersection_of: GO:0031984 ! organelle subcompartment
intersection_of: part_of GO:0005783 ! endoplasmic reticulum
relationship: part_of GO:0005783 ! endoplasmic reticulum

[Term]
id: GO:0098828
name: modulation of inhibitory postsynaptic potential
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of inhibitory postsynaptic potential (IPSP). IPSP is a temporary decrease in postsynaptic membrane potential due to the flow of negatively charged ions into the postsynaptic cell. The flow of ions that causes an IPSP is an inhibitory postsynaptic current (IPSC) and makes it more difficult for the neuron to fire an action potential." [GOC:dos]
synonym: "regulation of inhibitory postsynaptic potential" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0042391 ! regulation of membrane potential
is_a: GO:0050804 ! modulation of synaptic transmission
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: regulates GO:0060080 ! inhibitory postsynaptic potential
relationship: regulates GO:0060080 ! inhibitory postsynaptic potential

[Term]
id: GO:0098829
name: intestinal folate absorption
namespace: biological_process
def: "Uptake of folic into the blood by absorption from the small intestine." [GOC:BHF, GOC:dos, GOC:hal, PMID:19762432]
is_a: GO:0015884 ! folic acid transport
is_a: GO:0050892 ! intestinal absorption

[Term]
id: GO:0098830
name: presynaptic endosome
namespace: cellular_component
def: "An endosome present in the presynapse that fuses with endocytic vesicles arising in the presynaptic endocytic zone.  This organelle is believed to be involved in regeneration of synaptic vesicles." [PMID:20200227, PMID:25939282]
comment: As of 2015, there is still controversy over the nature of presynaptic endosomes and their relationship to regular endosomes.  See Jahne et al., 2015 (PMID:25939282) for details.
subset: goslim_synapse
is_a: GO:0005768 ! endosome
is_a: GO:0044456 ! synapse part
is_a: GO:0097458 ! neuron part
relationship: part_of GO:0098793 ! presynapse

[Term]
id: GO:0098831
name: presynaptic active zone cytoplasmic component
namespace: cellular_component
def: "A specialized region below the presynaptic membrane, characterized by electron-dense material, a specialized cytoskeletal matrix and accumulated (associated) synaptic vesicles." [GOC:dos]
subset: goslim_synapse
synonym: "cortex of presynaptic active zone" EXACT []
synonym: "presynaptic zone cortex" EXACT []
is_a: GO:0044456 ! synapse part
is_a: GO:0097458 ! neuron part
is_a: GO:0099738 ! cell cortex region
relationship: part_of GO:0048786 ! presynaptic active zone

[Term]
id: GO:0098832
name: peri-centrosomal recycling endosome
namespace: cellular_component
def: "A recycling endosome that is organized around the microtubule organizing center, close to the nucleus. This is the main recycling endosome of most cells. It receives input from the Golgi as well as recycled molecules from early endosomes." [PMID:19696797, PMID:20820847]
is_a: GO:0055037 ! recycling endosome

[Term]
id: GO:0098833
name: presynaptic endocytic zone
namespace: cellular_component
def: "A specialized region of the plasma membrane and underlying cytoplasm which surround the the active zone, into which synaptic vesicle membranes are recycled following exocytosis.  It is especially enriched in endocytic proteins following intense activity." [PMID:17455288]
comment: May be identical to periactive zone?
subset: goslim_synapse
is_a: GO:0044456 ! synapse part

[Term]
id: GO:0098834
name: presynaptic endocytic zone, cytoplasmic component
namespace: cellular_component
def: "The cytoplasmic component of the presynaptic endocytic zone." [GOC:dos]
subset: goslim_synapse
synonym: "cortex of presynaptic endocytic zone" EXACT []
is_a: GO:0044456 ! synapse part
is_a: GO:0099738 ! cell cortex region
relationship: part_of GO:0098833 ! presynaptic endocytic zone

[Term]
id: GO:0098835
name: presynaptic endocytic zone membrane
namespace: cellular_component
def: "The region of the presynaptic membrane that is part of the presynaptic endocytic zone - where synaptic vesicles are endocytosed and recycled following release." [GOC:dos]
subset: goslim_synapse
is_a: GO:0097060 ! synaptic membrane
is_a: GO:0097458 ! neuron part
intersection_of: GO:0016020 ! membrane
intersection_of: part_of GO:0042734 ! presynaptic membrane
intersection_of: part_of GO:0098833 ! presynaptic endocytic zone
relationship: part_of GO:0042734 ! presynaptic membrane
relationship: part_of GO:0098833 ! presynaptic endocytic zone

[Term]
id: GO:0098836
name: cytoskeleton of dendritic spine
namespace: cellular_component
def: "The portion of the cytoskeleton that lies within a dendritic spine.  The actin component of this cytoskeleton is involved in spine head remodelling in response to postsynaptic signalling." [PMID:24854120]
is_a: GO:0044463 ! cell projection part
is_a: GO:0097458 ! neuron part
is_a: GO:0099571 ! postsynaptic cytoskeleton
intersection_of: GO:0005856 ! cytoskeleton
intersection_of: part_of GO:0043197 ! dendritic spine
relationship: part_of GO:0043197 ! dendritic spine

[Term]
id: GO:0098837
name: postsynaptic recycling endosome
namespace: cellular_component
def: "A recycling endosome of the postsynapse. In postsynaptic terminals with dendritic spines, it is typically located at the base of a dendritic spine. It is involved in recycling of neurotransmitter receptors to the postsynaptic membrane.  In some cases at least, this recycling is activated by postsynaptic signalling and so can play a role in long term potentiation." [PMID:20820847]
subset: goslim_synapse
synonym: "endosomal recycling compartment" BROAD [PMID:20820847]
synonym: "recycling outpost" EXACT [PMID:20820847]
is_a: GO:0055037 ! recycling endosome
is_a: GO:0098845 ! postsynaptic endosome
intersection_of: GO:0055037 ! recycling endosome
intersection_of: part_of GO:0098794 ! postsynapse
relationship: part_of GO:0098794 ! postsynapse

[Term]
id: GO:0098838
name: reduced folate transmembrane transport
namespace: biological_process
def: "The directed movement of reduced folate (dihydrofolate, tetrahydrofolate, methylene-tetrahydrofolate or methyl-tetrahydrofolate) across a membrane." [PMID:14609557]
is_a: GO:0042886 ! amide transport
is_a: GO:0055085 ! transmembrane transport

[Term]
id: GO:0098839
name: postsynaptic density membrane
namespace: cellular_component
def: "The region of the postsynaptic membrane adjacent to the postsynaptic density." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099634 ! postsynaptic specialization membrane
relationship: part_of GO:0045211 ! postsynaptic membrane

[Term]
id: GO:0098840
name: protein transport along microtubule
namespace: biological_process
def: "The directed movement of a protein along a microtubule, mediated by motor proteins." [PMID:25987607]
synonym: "microtubule-based protein transport" EXACT []
is_a: GO:0006886 ! intracellular protein transport
is_a: GO:0010970 ! establishment of localization by movement along microtubule
is_a: GO:0030705 ! cytoskeleton-dependent intracellular transport

[Term]
id: GO:0098841
name: protein localization to cell division site after cytokinesis
namespace: biological_process
def: "A cellular protein localization process in which a protein is transported to, or maintained at, the site of cell division following cytokinesis." [PMID:25411334]
is_a: GO:0072741 ! protein localization to cell division site

[Term]
id: GO:0098842
name: postsynaptic early endosome
namespace: cellular_component
def: "An early endosome of the postsynapse. It acts as the major sorting station on the endocytic pathway, targeting neurotransmitter receptors for degregation or recycling." [PMID:19603039, PMID:20820847, PMID:24727350]
comment: Commonly used markers for postsynaptic early endosomes include RAB5A and EEA1.
subset: goslim_synapse
is_a: GO:0005769 ! early endosome
is_a: GO:0098845 ! postsynaptic endosome
intersection_of: GO:0005769 ! early endosome
intersection_of: part_of GO:0098794 ! postsynapse
relationship: part_of GO:0098794 ! postsynapse

[Term]
id: GO:0098843
name: postsynaptic endocytic zone
namespace: cellular_component
def: "A stably positioned site of clathrin adjacent and physically attached to the postsynaptic density, which is the site of endocytosis of post-synaptic proteins." [PMID:17880892]
subset: goslim_synapse
is_a: GO:0044456 ! synapse part
is_a: GO:0044464 ! cell part
relationship: has_part GO:0030118 ! clathrin coat
relationship: part_of GO:0098794 ! postsynapse

[Term]
id: GO:0098844
name: postsynaptic endocytic zone membrane
namespace: cellular_component
def: "The region of the postsynaptic membrane that is part of the postsynaptic endocytic zone.  This region of membrane is associated with stable clathrin puncta." [PMID:17880892]
subset: goslim_synapse
is_a: GO:0097060 ! synaptic membrane
intersection_of: GO:0016020 ! membrane
intersection_of: part_of GO:0045211 ! postsynaptic membrane
intersection_of: part_of GO:0098843 ! postsynaptic endocytic zone
relationship: part_of GO:0045211 ! postsynaptic membrane
relationship: part_of GO:0098843 ! postsynaptic endocytic zone

[Term]
id: GO:0098845
name: postsynaptic endosome
namespace: cellular_component
def: "An endosomal compartment that is part of the post-synapse. Only early and recycling endosomes are typically present in the postsynapse." [PMID:20820847]
is_a: GO:0005768 ! endosome
is_a: GO:0044456 ! synapse part
intersection_of: GO:0005768 ! endosome
intersection_of: part_of GO:0098794 ! postsynapse
relationship: part_of GO:0098794 ! postsynapse

[Term]
id: GO:0098846
name: podocyte foot
namespace: cellular_component
def: "A cell projection of a podocyte (glomerular visceral epithelial cell) forming a foot-like structure projecting from a podocyte primary projection, that wraps around capillaries of a renal glomerulus. Adjacent feet (pedicels) interdigitate, leaving thin filtration slits between them, which are covered by slit diaphragms." [PMID:25324828]
synonym: "pedicel" EXACT [Wikipedia:Podocyte]
synonym: "podocyte foot process" EXACT [PMID:25324828]
synonym: "secondary podocyte projection" EXACT []
xref: Wikipedia:Podocyte
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0098847
name: sequence-specific single stranded DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with single-stranded DNA of a specific nucleotide composition." [PMID:9531483]
is_a: GO:0003697 ! single-stranded DNA binding
is_a: GO:0043565 ! sequence-specific DNA binding

[Term]
id: GO:0098848
name: alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-ribose 1-methylphosphonate 5-phosphate = alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + methane." [EC:4.7.1.1, GOC:dos, GOC:ik]
synonym: "alpha-D-ribose-1-methylphosphonate-5-phosphate C-P-lyase (methane forming)" EXACT [EC:4.7.1.1]
xref: EC:4.7.1.1
is_a: GO:0018835 ! carbon phosphorus lyase activity

[Term]
id: GO:0098849
name: cellular detoxification of cadmium ion
namespace: biological_process
def: "Any process that reduces or removes the toxicity of cadmium cations in a cell. These include transport of cadmium cations away from sensitive areas and to compartments or complexes whose purpose is sequestration." [GOC:dos, GOC:vw]
is_a: GO:0071585 ! detoxification of cadmium ion
is_a: GO:1990748 ! cellular detoxification
relationship: part_of GO:0071276 ! cellular response to cadmium ion

[Term]
id: GO:0098850
name: extrinsic component of synaptic vesicle membrane
namespace: cellular_component
def: "The component of the synaptic vesicle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos]
subset: goslim_synapse
is_a: GO:0031312 ! extrinsic component of organelle membrane
is_a: GO:0044433 ! cytoplasmic vesicle part
is_a: GO:0044456 ! synapse part
is_a: GO:0097458 ! neuron part
intersection_of: GO:0019898 ! extrinsic component of membrane
intersection_of: part_of GO:0030672 ! synaptic vesicle membrane
relationship: part_of GO:0030672 ! synaptic vesicle membrane

[Term]
id: GO:0098851
name: double-stranded miRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with double-stranded miRNA. double-stranded miRNA is formed by processing of pre-miRNA stem-loop structures." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:19966796]
synonym: "miRNA duplex binding" EXACT []
is_a: GO:0003725 ! double-stranded RNA binding

[Term]
id: GO:0098852
name: lytic vacuole membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a lytic vacuole and separating its contents from the cytoplasm of the cell." [GOC:dos]
is_a: GO:0005774 ! vacuolar membrane

[Term]
id: GO:0098853
name: ER-vacuole membrane contact site
namespace: cellular_component
def: "A zone of apposition between endoplasmic-reticulum and lytic vacuole membranes, structured by bridging complexes." [GOC:dos, PMID:26283797]
synonym: "endoplasmic reticulum-vacuole membrane contact site" EXACT []
is_a: GO:0044232 ! organelle membrane contact site

[Term]
id: GO:0098854
name: podocyte primary projection
namespace: cellular_component
def: "A cell projection originating from a renal glomerular podocyte and extending to the renal glomerular podocyte foot." [PMID:24309184, PMID:25324828]
synonym: "glomerular visceral epithelial cell primary projection" EXACT []
synonym: "podocyte major process" EXACT []
synonym: "primary podocyte process" EXACT []
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0098855
name: HCN channel complex
namespace: cellular_component
def: "A cation ion channel that consists of a tetramer of HCN family members,  has a preference for K+ over Na+ ions and is activated by membrane hyperpolarization.  Some members of this family (HCN1, HCN2 and HCN4) are also activated when cAMP binds to their cyclic nucleotide binding domain (CNBD). Channel complexes of this family play an important role in the control of pacemaker activity in the heart." [PMID:20829353]
is_a: GO:0008076 ! voltage-gated potassium channel complex

[Term]
id: GO:0098856
name: intestinal lipid absorption
namespace: biological_process
def: "Any process in which lipids are taken up from the contents of the intestine." [GOC:dos, GOC:sl, PMID:18768481]
is_a: GO:0006869 ! lipid transport
is_a: GO:0050892 ! intestinal absorption

[Term]
id: GO:0098857
name: membrane microdomain
namespace: cellular_component
def: "A membrane region with a lipid composition that is distinct from that of the membrane regions that surround it." [PMID:20044567, PMID:26253820]
is_a: GO:0098589 ! membrane region

[Term]
id: GO:0098858
name: actin-based cell projection
namespace: cellular_component
def: "A cell projection supported by an assembly of actin filaments, and which lacks microtubules." [PMID:15661519]
is_a: GO:0042995 ! cell projection
relationship: has_part GO:0005884 ! actin filament

[Term]
id: GO:0098859
name: actin filament bundle of actin-based cell projection
namespace: cellular_component
def: "A bundle of cross-linked actin filaments that is part of an actin-based cell protrusion, in which filaments are oriented such that the plus (barbed) ends are at the tip of the protrusion, capped by a tip complex which stabilizes the filaments." [PMID:12566431, PMID:15661519]
is_a: GO:0044463 ! cell projection part
is_a: GO:0097518 ! parallel actin filament bundle
intersection_of: GO:0097518 ! parallel actin filament bundle
intersection_of: part_of GO:0098858 ! actin-based cell projection
relationship: part_of GO:0098858 ! actin-based cell projection

[Term]
id: GO:0098860
name: actin filament bundle of stereocilium
namespace: cellular_component
def: "A bundle of hundreds of cross-linked actin filaments (an actin cable), that is the supporting structure of a stereocilium.  Filaments are oriented such that the the plus (barbed) ends are at the tip of the protrusion and are capped by a tip complex which bridges to the plasma membrane." [PMID:15661519]
is_a: GO:0097458 ! neuron part
is_a: GO:0098859 ! actin filament bundle of actin-based cell projection
intersection_of: GO:0097518 ! parallel actin filament bundle
intersection_of: part_of GO:0032420 ! stereocilium
relationship: part_of GO:0032420 ! stereocilium

[Term]
id: GO:0098861
name: actin filament bundle of filopodium
namespace: cellular_component
def: "A parallel bundle of actin filaments that is part of filopodium. Filaments are oriented such that the plus (barbed) ends are at the tip of the protrusion, capped by a tip complex." [PMID:12566431]
is_a: GO:0098859 ! actin filament bundle of actin-based cell projection
intersection_of: GO:0097518 ! parallel actin filament bundle
intersection_of: part_of GO:0030175 ! filopodium
relationship: part_of GO:0030175 ! filopodium

[Term]
id: GO:0098862
name: cluster of actin-based cell projections
namespace: cellular_component
def: "A cell part consisting of multiple, closely packed actin-based cell projections. " [GOC:dos]
is_a: GO:0044464 ! cell part
relationship: has_part GO:0098858 ! actin-based cell projection

[Term]
id: GO:0098863
name: nuclear migration by microtubule mediated pushing forces
namespace: biological_process
def: "The directed movement of the nucleus by pushing forces exerted by polymerization of backward-extending microtubules." [GOC:vw, PMID:11309419, PMID:16611238]
is_a: GO:0007097 ! nuclear migration

[Term]
id: GO:0098864
name: modification by symbiont of host occluding cell-cell junction
namespace: biological_process
def: "The process in which a symbiont organism effects a change in the structure or function of its host occluding junction, a cell-cell junction that seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other." [PMID:24287273]
is_a: GO:0044067 ! modification by symbiont of host intercellular junctions

[Term]
id: GO:0098865
name: modification by symbiont of host bicellular tight junctions
namespace: biological_process
def: "The process in which an organism effects a change in the structure or function of its host bicellular tight junctions, an occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet" [PMID:24287273]
is_a: GO:0098864 ! modification by symbiont of host occluding cell-cell junction

[Term]
id: GO:0098866
name: multivesicular body fusion to apical plasma membrane
namespace: biological_process
def: "The fusion of the membrane of a multivesicular body with the apical plasma membrane, resulting in release of exosomes from the cell." [PMID:26459596]
is_a: GO:0045026 ! plasma membrane fusion
is_a: GO:0090174 ! organelle membrane fusion
is_a: GO:0097576 ! vacuole fusion
relationship: part_of GO:1990182 ! exosomal secretion

[Term]
id: GO:0098867
name: intramembranous bone growth
namespace: biological_process
def: "The increase in size or mass of an endochondral bone that contributes to the shaping of the bone." [PMID:26399686]
is_a: GO:0098868 ! bone growth

[Term]
id: GO:0098868
name: bone growth
namespace: biological_process
def: "The increase in size or mass of a bone that contributes to the shaping of that bone." [GOC:dos]
is_a: GO:0035265 ! organ growth

[Term]
id: GO:0098869
name: cellular oxidant detoxification
namespace: biological_process
def: "Any process carried out at the cellular level that reduces or removes the toxicity superoxide radicals or hydrogen peroxide." [GOC:dos, GOC:vw]
is_a: GO:1990748 ! cellular detoxification

[Term]
id: GO:0098870
name: action potential propagation
namespace: biological_process
def: "The propagation of an action potential along the plane of an excitable membrane.  Action potentials typically propagate once triggered because the depolarization of adjacent membrane regions due to an action potential crosses the firing threshold." [GOC:dos]
is_a: GO:0001508 ! action potential

[Term]
id: GO:0098871
name: postsynaptic actin cytoskeleton
namespace: cellular_component
def: "The actin cytoskeleton that is part of a postsynapse" [GOC:dos]
subset: goslim_synapse
is_a: GO:0015629 ! actin cytoskeleton
is_a: GO:0099571 ! postsynaptic cytoskeleton
intersection_of: GO:0015629 ! actin cytoskeleton
intersection_of: part_of GO:0098794 ! postsynapse
relationship: part_of GO:0098794 ! postsynapse

[Term]
id: GO:0098872
name: G-protein coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium levels
namespace: molecular_function
def: "G-protein coupled neurotransmitter receptor activity occurring in the postsynaptic membrane that is part of a GPCR signaling pathway that positively regulates ion channel activity in the postsynaptic membrane." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099528 ! G-protein coupled neurotransmitter receptor activity
is_a: GO:0099583 ! neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium levels
intersection_of: GO:0099528 ! G-protein coupled neurotransmitter receptor activity
intersection_of: part_of GO:0099566 ! regulation of postsynaptic cytosolic calcium ion concentration
relationship: occurs_in GO:0045211 ! postsynaptic membrane
relationship: part_of GO:0099566 ! regulation of postsynaptic cytosolic calcium ion concentration

[Term]
id: GO:0098873
name: neuronal action potential back-propagation
namespace: biological_process
def: "Propagation of an action potential in a neuron, from its site of initiation (typically the axon hillock) towards the soma." [GOC:dos]
is_a: GO:0098870 ! action potential propagation

[Term]
id: GO:0098874
name: spike train
namespace: biological_process
alt_id: GO:0099603
def: "A series of sequential, propagated action potentials occurring in a single cell." [ISBN:978-0071390118]
synonym: "burst of action potentials" EXACT []
synonym: "spike-train" EXACT []
is_a: GO:0042391 ! regulation of membrane potential
relationship: has_part GO:0001508 ! action potential

[Term]
id: GO:0098875
name: epididymosome
namespace: cellular_component
def: "A microvesicle of the epididymal fluid, from which spermatozoa aquire membrane proteins." [GOC:dos, GOC:mg, PMID:23177142, PMID:26112475]
is_a: GO:1990742 ! microvesicle

[Term]
id: GO:0098900
name: regulation of action potential
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:dos, GOC:dph, GOC:go_curators, GOC:tb, ISBN:978-0-07-139011-8]
comment: The ion channels through which current flows during an action potential should be annotated to the process 'action potential'. Gene products involved in modulating the characteristics of an action potential via changing the expression levels or the activity of these channels (e.g. modulating their kinetics or voltage sensitivity) should be annotated to this regulation term.
is_a: GO:0042391 ! regulation of membrane potential
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: regulates GO:0001508 ! action potential
relationship: regulates GO:0001508 ! action potential

[Term]
id: GO:0098901
name: regulation of cardiac muscle cell action potential
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:dos, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0098900 ! regulation of action potential
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: regulates GO:0086001 ! cardiac muscle cell action potential
relationship: regulates GO:0086001 ! cardiac muscle cell action potential

[Term]
id: GO:0098902
name: regulation of membrane depolarization during action potential
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of membrane depolarization during an action potential. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential." [GOC:dos, GOC:dph, GOC:tb, ISBN:978-0-07-139011-8]
is_a: GO:0003254 ! regulation of membrane depolarization
is_a: GO:0098900 ! regulation of action potential
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: regulates GO:0086010 ! membrane depolarization during action potential
relationship: regulates GO:0086010 ! membrane depolarization during action potential

[Term]
id: GO:0098903
name: regulation of membrane repolarization during action potential
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of membrane repolarization during an action potential. Membrane repolarization is the process in which membrane potential changes in the repolarizing direction, towards the resting potential." [GOC:dos, GOC:dph, GOC:tb, ISBN:978-0-07-139011-8]
is_a: GO:0060306 ! regulation of membrane repolarization
is_a: GO:0098900 ! regulation of action potential
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: regulates GO:0086011 ! membrane repolarization during action potential
relationship: regulates GO:0086011 ! membrane repolarization during action potential

[Term]
id: GO:0098904
name: regulation of AV node cell action potential
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an atrioventricular node myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "regulation of atrioventricular node cardiac muscle cell action potential" EXACT []
synonym: "regulation of AV node cardiac muscle cell action potential" EXACT []
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0098901 ! regulation of cardiac muscle cell action potential
is_a: GO:1903779 ! regulation of cardiac conduction
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: regulates GO:0086016 ! AV node cell action potential
relationship: regulates GO:0086016 ! AV node cell action potential
created_by: tanyaberardini
creation_date: 2011-11-10T08:58:56Z

[Term]
id: GO:0098905
name: regulation of bundle of His cell action potential
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell of the bundle of His. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "regulation of bundle of His cardiac muscle cell action potential" EXACT []
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0098901 ! regulation of cardiac muscle cell action potential
is_a: GO:1903779 ! regulation of cardiac conduction
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: regulates GO:0086043 ! bundle of His cell action potential
relationship: regulates GO:0086043 ! bundle of His cell action potential
created_by: dph
creation_date: 2011-11-15T12:01:18Z

[Term]
id: GO:0098906
name: regulation of Purkinje myocyte action potential
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a Purkinje myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0098901 ! regulation of cardiac muscle cell action potential
is_a: GO:1903779 ! regulation of cardiac conduction
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: regulates GO:0086017 ! Purkinje myocyte action potential
relationship: regulates GO:0086017 ! Purkinje myocyte action potential
created_by: tanyaberardini
creation_date: 2011-11-10T08:58:56Z

[Term]
id: GO:0098907
name: regulation of SA node cell action potential
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an SA node cardiac myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "regulation of SA node cardiac muscle cell action potential" EXACT []
synonym: "regulation of SAN cardiac muscle cell action potential" EXACT []
synonym: "regulation of sinoatrial node cardiac muscle cell action potential" EXACT []
synonym: "regulation of sinus node cardiac muscle cell action potential" NARROW []
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0098901 ! regulation of cardiac muscle cell action potential
is_a: GO:1903779 ! regulation of cardiac conduction
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: regulates GO:0086015 ! SA node cell action potential
relationship: regulates GO:0086015 ! SA node cell action potential
created_by: tanyaberardini
creation_date: 2011-11-10T08:50:15Z

[Term]
id: GO:0098908
name: regulation of neuronal action potential
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a neuron. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:dph, GOC:isa_complete, GOC:tb]
synonym: "generation of action potential" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051969 ! regulation of transmission of nerve impulse
is_a: GO:0098900 ! regulation of action potential
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: regulates GO:0019228 ! neuronal action potential
relationship: regulates GO:0019228 ! neuronal action potential

[Term]
id: GO:0098909
name: regulation of cardiac muscle cell action potential involved in regulation of contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell contributing to the regulation of its contraction." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0098901 ! regulation of cardiac muscle cell action potential
intersection_of: GO:0065007 ! biological regulation
intersection_of: part_of GO:0086004 ! regulation of cardiac muscle cell contraction
intersection_of: regulates GO:0086001 ! cardiac muscle cell action potential
relationship: part_of GO:0086004 ! regulation of cardiac muscle cell contraction
relationship: regulates GO:0086001 ! cardiac muscle cell action potential
created_by: tanyaberardini
creation_date: 2011-11-10T07:45:11Z

[Term]
id: GO:0098910
name: regulation of atrial cardiac muscle cell action potential
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an atrial cardiac muscle cell contributing to the regulation of its contraction. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0086004 ! regulation of cardiac muscle cell contraction
is_a: GO:0098901 ! regulation of cardiac muscle cell action potential
is_a: GO:1903779 ! regulation of cardiac conduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0086014 ! atrial cardiac muscle cell action potential
relationship: regulates GO:0086014 ! atrial cardiac muscle cell action potential
created_by: tanyaberardini
creation_date: 2011-11-10T08:49:13Z

[Term]
id: GO:0098911
name: regulation of ventricular cardiac muscle cell action potential
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a ventricular cardiac muscle cell contributing to the regulation of its contraction.  This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0086004 ! regulation of cardiac muscle cell contraction
is_a: GO:0098901 ! regulation of cardiac muscle cell action potential
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0086005 ! ventricular cardiac muscle cell action potential
relationship: regulates GO:0086005 ! ventricular cardiac muscle cell action potential
created_by: tanyaberardini
creation_date: 2011-11-10T07:59:36Z

[Term]
id: GO:0098912
name: membrane depolarization during atrial cardiac muscle cell action potential
namespace: biological_process
def: "The process in which atrial cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:dph, GOC:mtg_cardiac_conduct_nov11, GOC:tb]
synonym: "atrial cardiac muscle cell depolarization" BROAD [GOC:dph, GOC:tb]
synonym: "atrial depolarization" RELATED [GOC:dph, GOC:tb]
synonym: "electrocardiogram PR interval" RELATED [GOC:dph, GOC:tb]
is_a: GO:0086012 ! membrane depolarization during cardiac muscle cell action potential
intersection_of: GO:0051899 ! membrane depolarization
intersection_of: part_of GO:0086014 ! atrial cardiac muscle cell action potential
relationship: part_of GO:0086014 ! atrial cardiac muscle cell action potential

[Term]
id: GO:0098913
name: membrane depolarization during ventricular cardiac muscle cell action potential
namespace: biological_process
def: "The process in which ventricular cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:dph, GOC:mtg_cardiac_conduct_nov11, GOC:tb]
synonym: "electrocardiogram QRS complex" RELATED [GOC:dph, GOC:tb]
synonym: "ventricular depolarization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0086012 ! membrane depolarization during cardiac muscle cell action potential
intersection_of: GO:0051899 ! membrane depolarization
intersection_of: part_of GO:0086005 ! ventricular cardiac muscle cell action potential
relationship: part_of GO:0086005 ! ventricular cardiac muscle cell action potential

[Term]
id: GO:0098914
name: membrane repolarization during atrial cardiac muscle cell action potential
namespace: biological_process
def: "The process in which ions are transported across a membrane such that the atrial cardiomyocyte membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential." [GOC:dph, GOC:mtg_cardiac_conduct_nov11, GOC:tb]
synonym: "atrial repolarization" RELATED [GOC:dph, GOC:tb]
synonym: "electrocardiogram QRS complex" RELATED [GOC:dph, GOC:tb]
is_a: GO:0086013 ! membrane repolarization during cardiac muscle cell action potential
is_a: GO:0099624 ! atrial cardiac muscle cell membrane repolarization
intersection_of: GO:0086009 ! membrane repolarization
intersection_of: part_of GO:0086014 ! atrial cardiac muscle cell action potential
relationship: part_of GO:0086014 ! atrial cardiac muscle cell action potential

[Term]
id: GO:0098915
name: membrane repolarization during ventricular cardiac muscle cell action potential
namespace: biological_process
def: "The process in which ions are transported across a membrane such that the ventricular cardiomyocyte membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential." [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11, GOC:tb]
synonym: "electrocardiogram T wave" RELATED [GOC:dph, GOC:tb]
synonym: "regulation of ventricular cardiac muscle repolarization" RELATED [GOC:dph, GOC:tb]
synonym: "ventricular repolarization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0086013 ! membrane repolarization during cardiac muscle cell action potential
is_a: GO:0099625 ! ventricular cardiac muscle cell membrane repolarization
intersection_of: GO:0086009 ! membrane repolarization
intersection_of: part_of GO:0086005 ! ventricular cardiac muscle cell action potential
relationship: part_of GO:0086005 ! ventricular cardiac muscle cell action potential

[Term]
id: GO:0098916
name: anterograde trans-synaptic signaling
namespace: biological_process
def: "Cell-cell signaling from pre to post-synapse, across the synaptic cleft" [GOC:dos]
is_a: GO:0099537 ! trans-synaptic signaling

[Term]
id: GO:0098917
name: retrograde trans-synaptic signaling
namespace: biological_process
def: "Cell-cell signaling from post to pre-synapse, across the synaptic cleft" [GOC:dos]
is_a: GO:0099537 ! trans-synaptic signaling

[Term]
id: GO:0098918
name: structural constituent of synapse
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of a synapse." [GOC:dos]
subset: goslim_synapse
is_a: GO:0005198 ! structural molecule activity
intersection_of: GO:0005198 ! structural molecule activity
intersection_of: part_of GO:0099558 ! maintenance of synapse structure
relationship: part_of GO:0099558 ! maintenance of synapse structure

[Term]
id: GO:0098919
name: structural constituent of postsynaptic density
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of a postsynaptic density." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098918 ! structural constituent of synapse
intersection_of: GO:0005198 ! structural molecule activity
intersection_of: part_of GO:0099562 ! maintenance of postsynaptic density structure
relationship: part_of GO:0099562 ! maintenance of postsynaptic density structure

[Term]
id: GO:0098920
name: retrograde trans-synaptic signaling by lipid
namespace: biological_process
def: "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a lipid ligand." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098917 ! retrograde trans-synaptic signaling
is_a: GO:0099541 ! trans-synaptic signaling by lipid

[Term]
id: GO:0098921
name: retrograde trans-synaptic signaling by endocannabinoid
namespace: biological_process
def: "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by an  endocannabinoid ligand." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098920 ! retrograde trans-synaptic signaling by lipid
is_a: GO:0099542 ! trans-synaptic signaling by endocannabinoid

[Term]
id: GO:0098923
name: retrograde trans-synaptic signaling by soluble gas
namespace: biological_process
def: "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by an soluble gas ligand." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098917 ! retrograde trans-synaptic signaling
is_a: GO:0099543 ! trans-synaptic signaling by soluble gas

[Term]
id: GO:0098924
name: retrograde trans-synaptic signaling by nitric oxide
namespace: biological_process
def: "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by nitric oxide." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098923 ! retrograde trans-synaptic signaling by soluble gas
is_a: GO:0099548 ! trans-synaptic signaling by nitric oxide

[Term]
id: GO:0098925
name: retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission
namespace: biological_process
def: "Modulation of synaptic transmission by cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by nitric oxide." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098924 ! retrograde trans-synaptic signaling by nitric oxide
is_a: GO:0099555 ! trans-synaptic signaling by nitric oxide, modulating synaptic transmission
relationship: regulates GO:0007268 ! synaptic transmission

[Term]
id: GO:0098926
name: postsynaptic signal transduction
namespace: biological_process
def: "Signal transduction in which the initial step occurs in a postsynapse." [GOC:dos]
comment: Do not directly annotate. This term is intended for automatically grouping annotations to signal transduction classes extended with has_start_location/occurs_in postsynapse or one of its parts.
subset: gocheck_do_not_manually_annotate
subset: goslim_synapse
is_a: GO:0007165 ! signal transduction
relationship: part_of GO:0099536 ! synaptic signaling

[Term]
id: GO:0098927
name: vesicle-mediated transport between endosomal compartments
namespace: biological_process
def: "A cellular transport process in which transported substances are moved in membrane-bounded vesicles between endosomal compartments, e.g, between early endosome and sorting endosome." [GOC:dos, PMID:10930469]
is_a: GO:0016192 ! vesicle-mediated transport
is_a: GO:0016197 ! endosomal transport

[Term]
id: GO:0098928
name: presynaptic signal transduction
namespace: biological_process
def: "Signal transduction in which the initial step occurs in a presynapse." [GOC:dos]
comment: Do not directly annotate. This term intended for grouping.  Annotate to either a subclass or to some other subclass of signal transduction  extended with has_start_location/occurs_in presynapse or one of its parts.  Such extensions will result in automatic annotation to this term.
subset: goslim_synapse
is_a: GO:0007165 ! signal transduction

[Term]
id: GO:0098931
name: virion attachment to host cell flagellum
namespace: biological_process
def: "The process by which a virion attaches to a host cell by binding to the flagellum of a cell surface." [GOC:dos, VZ:3949]
subset: virus_checked
xref: VZ:3949 "Pilus-mediated viral adsorption onto host cell"
is_a: GO:0019062 ! virion attachment to host cell

[Term]
id: GO:0098932
name: disruption by virus of host cell wall petidoglycan during virus entry
namespace: biological_process
def: "A process carried out by a symbiot that breaks down peptidoglycans in the cell wall of its host . The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:dos, VZ:3940]
subset: gosubset_prok
synonym: "catabolism of host cell wall peptidoglycan by organism" EXACT []
synonym: "degradation of host cell wall petidoglycan by organism" EXACT []
synonym: "degradation of host peptidoglycans during virus entry" EXACT [] {comment="VZ:3940"}
synonym: "disassembly by organism of host cell wall peptidoglycan" EXACT []
synonym: "disassembly by symbiont of host cell wall peptidoglycan" EXACT []
xref: VZ:3940
is_a: GO:0044661 ! disruption by virus of host cell
is_a: GO:0052009 ! disruption by symbiont of host cell wall
relationship: part_of GO:0046718 ! viral entry into host cell

[Term]
id: GO:0098933
name: disruption by symbiont of host cell envelope
namespace: biological_process
def: "The breakdown of the host cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
subset: gosubset_prok
synonym: "catabolism of host cell wall by organism" EXACT []
synonym: "degradation of host cell wall by organism" EXACT []
synonym: "disassembly by organism of host cell wall" EXACT []
synonym: "disassembly by symbiont of host cell wall" EXACT []
is_a: GO:0052008 ! disruption by symbiont of host cellular component
is_a: GO:0052020 ! modification by symbiont of host cell wall
is_a: GO:0052339 ! disruption by organism of cell wall of other organism involved in symbiotic interaction

[Term]
id: GO:0098938
name: actin cytoskeleton of dendritic spine
namespace: cellular_component
def: "The actin cytoskeleton that is part of a dendritic spine." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098836 ! cytoskeleton of dendritic spine
is_a: GO:0098871 ! postsynaptic actin cytoskeleton
intersection_of: GO:0015629 ! actin cytoskeleton
intersection_of: part_of GO:0043197 ! dendritic spine
relationship: part_of GO:0043197 ! dendritic spine

[Term]
id: GO:0098940
name: anterograde trans-synaptic signaling by nitric oxide
namespace: biological_process
def: "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by nitric oxide." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098916 ! anterograde trans-synaptic signaling
is_a: GO:0099548 ! trans-synaptic signaling by nitric oxide

[Term]
id: GO:0098941
name: anterograde trans-synaptic signaling by trans-synaptic protein complex
namespace: biological_process
def: "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a trans-synaptic protein complex." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098916 ! anterograde trans-synaptic signaling
is_a: GO:0099545 ! trans-synaptic signaling by trans-synaptic complex

[Term]
id: GO:0098942
name: retrograde trans-synaptic signaling by trans-synaptic protein complex
namespace: biological_process
def: "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by trans-synaptic protein complex." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098923 ! retrograde trans-synaptic signaling by soluble gas
is_a: GO:0099545 ! trans-synaptic signaling by trans-synaptic complex

[Term]
id: GO:0099400
name: caveola neck
namespace: cellular_component
def: "A membrane microdomain that forms a necklace around the bulb (crater) of a caveola.  Intramembrane particles are concentrated in this region and cytoskeletal components, including actin, are highly enriched in the area underlying it." [GOC:pad, GOC:PARL, PMID:17227843]
is_a: GO:0098590 ! plasma membrane region
is_a: GO:0098857 ! membrane microdomain
relationship: part_of GO:0005901 ! caveola

[Term]
id: GO:0099401
name: caveola bulb
namespace: cellular_component
def: "The region of a caveola that extends into the cytoplasm, excluding the neck (rim).  This region is associated with intracellular caveola proteins." [GOC:PARL, GOC:POD, PMID:17227843]
synonym: "caveola crater" EXACT []
is_a: GO:0098857 ! membrane microdomain

[Term]
id: GO:0099402
name: plant organ development
namespace: biological_process
def: "Development of a plant organ, a multi-tissue plant structure that forms a functional unit." [GOC:dos]
synonym: "development of a plant organ" EXACT []
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048731 ! system development

[Term]
id: GO:0099403
name: maintenance of mitotic sister chromatid cohesion, telomeric
namespace: biological_process
def: "The process in which the association between sister chromatids of a replicated chromosome along the length of the telomeric region is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a mitotic cell cycle." [GOC:BHF, GOC:BHF_telomere, GOC:dos, GOC:rph, PMID:26373281]
synonym: "maintenance of mitotic sister chromatin cohesion at telomere" EXACT [GOC:mah]
synonym: "maintenance of sister chromatin cohesion at telomere at mitosis" EXACT [GOC:mah]
synonym: "maintenance of telomeric mitotic sister chromatin cohesion" EXACT [GOC:mah]
is_a: GO:0034088 ! maintenance of mitotic sister chromatid cohesion
relationship: part_of GO:0099404 ! mitotic sister chromatid cohesion, telomeric

[Term]
id: GO:0099404
name: mitotic sister chromatid cohesion, telomeric
namespace: biological_process
def: "The cell cycle process in which telomeres of sister chromatids are joined during mitosis." [GOC:BHF, GOC:BHF_telomere, GOC:mah, GOC:rph, PMID:26373281]
synonym: "mitotic sister chromatid cohesion at telomere" EXACT [GOC:mah]
synonym: "sister chromatid cohesion at telomere at mitosis" EXACT [GOC:mah]
synonym: "telomeric mitotic sister chromatin cohesion" EXACT [GOC:mah]
is_a: GO:0007064 ! mitotic sister chromatid cohesion

[Term]
id: GO:0099500
name: vesicle fusion to plasma membrane
namespace: biological_process
def: "Fusion of the membrane of a vesicle with the plasma membrane, thereby releasing its contents into the extracellular space." [ISBN:0071120009]
is_a: GO:0006906 ! vesicle fusion
is_a: GO:0045026 ! plasma membrane fusion
relationship: part_of GO:0006887 ! exocytosis

[Term]
id: GO:0099501
name: exocytic vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding an exocytic vesicle" [GOC:dos]
synonym: "secretory vesicle membrane" BROAD []
is_a: GO:0030658 ! transport vesicle membrane

[Term]
id: GO:0099502
name: calcium-dependent activation of synaptic vesicle fusion
namespace: biological_process
def: "The regulatory process by which increased cytosolic calcium levels lead to the the fusion of synaptic vesicles with the presynaptic active zone membrane by bringing primed synaptic vesicle membrane into contact with membrane presynaptic active zone membrane." [PMID:23060190]
subset: goslim_synapse
is_a: GO:0031632 ! positive regulation of synaptic vesicle fusion to presynaptic membrane
is_a: GO:0099531 ! presynaptic process involved in synaptic transmission
relationship: part_of GO:0016079 ! synaptic vesicle exocytosis
relationship: positively_regulates GO:0031629 ! synaptic vesicle fusion to presynaptic active zone membrane

[Term]
id: GO:0099503
name: secretory vesicle
namespace: cellular_component
def: "A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space." [GOC:dos]
is_a: GO:0016023 ! cytoplasmic, membrane-bounded vesicle

[Term]
id: GO:0099504
name: synaptic vesicle cycle
namespace: biological_process
def: "A biological process in which synaptic vesicles are loaded with neurotransmitters, move to the active zone, exocytose and are then recycled via endocytosis, ultimately leading to reloading with neurotransmitters." [PMID:15217342]
subset: goslim_synapse
is_a: GO:0006810 ! transport
is_a: GO:0051649 ! establishment of localization in cell
relationship: occurs_in GO:0098793 ! presynapse

[Term]
id: GO:0099505
name: regulation of presynaptic membrane potential
namespace: biological_process
def: "Any process that modulates the potential difference across a presynaptic membrane." [GOC:dph, GOC:ef]
subset: goslim_synapse
synonym: "regulation of pre-synaptic membrane potential" EXACT []
is_a: GO:0042391 ! regulation of membrane potential

[Term]
id: GO:0099506
name: synaptic vesicle transport along actin filament
namespace: biological_process
def: "The directed movement of synaptic vesicles along actin filaments within a cell, powered by molecular motors." [GOC:dos]
subset: goslim_synapse
is_a: GO:0030050 ! vesicle transport along actin filament
is_a: GO:0099514 ! synaptic vesicle cytoskeletal transport

[Term]
id: GO:0099507
name: ligand-gated ion channel activity involved in regulation of presynaptic membrane potential
namespace: molecular_function
def: "Any ligand-gated ion channel activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential." [GOC:dos, PMID:15145529, PMID:19558451]
subset: goslim_synapse
synonym: "ligand gated ion channel activity involved in regulation of presynaptic membrane potential" EXACT []
synonym: "ligand-dependent ion channel activity involved in regulation of pre-synaptic membrane potential" EXACT []
synonym: "ligand-dependent ion channel activity involved in regulation of presynaptic membrane potential" EXACT []
synonym: "ligand-gated ion channel activity involved in regulation of pre-synaptic membrane potential" EXACT []
is_a: GO:0015276 ! ligand-gated ion channel activity
intersection_of: GO:0015276 ! ligand-gated ion channel activity
intersection_of: part_of GO:0099505 ! regulation of presynaptic membrane potential
relationship: occurs_in GO:0042734 ! presynaptic membrane
relationship: part_of GO:0099505 ! regulation of presynaptic membrane potential

[Term]
id: GO:0099508
name: voltage-gated ion channel activity involved in regulation of presynaptic membrane potential
namespace: molecular_function
def: "Voltage-gated ion channel activity, occurring in the presynaptic membrane, involved in regulation of presynaptic membrane potential. This is a key step in synaptic transmission, following the arrival of an action potential at the synapse." [GOC:dos]
subset: goslim_synapse
synonym: "voltage gated ion channel activity involved in regulation of presynaptic membrane potential" EXACT []
synonym: "voltage-dependent ion channel activity involved in regulation of pre-synaptic membrane potential" EXACT []
synonym: "voltage-dependent ion channel activity involved in regulation of presynaptic membrane potential" EXACT []
synonym: "voltage-gated ion channel activity involved in regulation of pre-synaptic membrane potential" EXACT []
is_a: GO:0005244 ! voltage-gated ion channel activity
intersection_of: GO:0005244 ! voltage-gated ion channel activity
intersection_of: part_of GO:0099505 ! regulation of presynaptic membrane potential
relationship: occurs_in GO:0042734 ! presynaptic membrane
relationship: part_of GO:0099505 ! regulation of presynaptic membrane potential

[Term]
id: GO:0099509
name: regulation of presynaptic cytosolic calcium ion concentration
namespace: biological_process
def: "Any process that regulates the concentration of calcium in the presynaptic cytosol." [GOC:dos]
subset: goslim_synapse
is_a: GO:0051480 ! regulation of cytosolic calcium ion concentration
is_a: GO:0070050 ! neuron cellular homeostasis
intersection_of: GO:0051480 ! regulation of cytosolic calcium ion concentration
intersection_of: occurs_in GO:0098793 ! presynapse
relationship: occurs_in GO:0098793 ! presynapse

[Term]
id: GO:0099510
name: calcium ion binding involved in regulation of cytosolic calcium ion concentration
namespace: molecular_function
def: "The directed change of cytosolic calcium ion concentration in the cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in cytosolic calcium concentrations." [PMID:24442513, PMID:26190970]
synonym: "regulation of cytosolic calcium ion concentration by calcium ion buffering" EXACT []
is_a: GO:0005509 ! calcium ion binding
intersection_of: GO:0005509 ! calcium ion binding
intersection_of: part_of GO:0051480 ! regulation of cytosolic calcium ion concentration
relationship: occurs_in GO:0005829 ! cytosol
relationship: part_of GO:0051480 ! regulation of cytosolic calcium ion concentration

[Term]
id: GO:0099511
name: voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels
namespace: molecular_function
def: "Regulation of cytosolic calcium ion concentrations via the directed movement of calcium ions across the plasma-membrane into the cytosol via the action of a voltage-gated calcium ion channel. " [GOC:dos]
subset: goslim_synapse
is_a: GO:0005245 ! voltage-gated calcium channel activity
intersection_of: GO:0005245 ! voltage-gated calcium channel activity
intersection_of: part_of GO:0051480 ! regulation of cytosolic calcium ion concentration
relationship: part_of GO:0051480 ! regulation of cytosolic calcium ion concentration

[Term]
id: GO:0099512
name: supramolecular fiber
namespace: cellular_component
def: "A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:dos]
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0099513
name: polymeric cytoskeletal fiber
namespace: cellular_component
def: "A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits." [GOC:dos]
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0099512 ! supramolecular fiber
relationship: part_of GO:0005856 ! cytoskeleton

[Term]
id: GO:0099514
name: synaptic vesicle cytoskeletal transport
namespace: biological_process
def: "The directed movement of synaptic vesicles along cytoskeletal fibers such as microfilaments or microtubules within a cell, powered by molecular motors." [GOC:dos]
subset: goslim_synapse
is_a: GO:0048489 ! synaptic vesicle transport
is_a: GO:0099518 ! vesicle cytoskeletal trafficking

[Term]
id: GO:0099515
name: actin filament-based transport
namespace: biological_process
def: "The transport of organelles or other particles from one location in the cell to another along actin filaments." [GOC:dos, GOC:dph, GOC:mah, GOC:tb]
is_a: GO:0030705 ! cytoskeleton-dependent intracellular transport
created_by: tanyaberardini
creation_date: 2009-05-27T10:56:08Z

[Term]
id: GO:0099516
name: ion antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ion A(out) + ion B(in) = ion A(in) + ion B(out) where ion A and ion B are different types of ion." [GOC:dos]
is_a: GO:0015297 ! antiporter activity
is_a: GO:0022853 ! active ion transmembrane transporter activity

[Term]
id: GO:0099517
name: synaptic vesicle transport along microtubule
namespace: biological_process
def: "The directed movement of synaptic vesicles along microtubules within a cell, powered by molecular motors." [GOC:dos]
subset: goslim_synapse
is_a: GO:0047496 ! vesicle transport along microtubule
is_a: GO:0099514 ! synaptic vesicle cytoskeletal transport

[Term]
id: GO:0099518
name: vesicle cytoskeletal trafficking
namespace: biological_process
def: "The directed movement of a vesicle along a cytoskeletal fiber such as a microtubule or and actin filament, mediated by motor proteins. " [GOC:ecd, GOC:rl]
synonym: "cytoskeletal fiber-based vesicle localization" EXACT [GOC:rl]
synonym: "vesicle cytoskeletal transport" EXACT []
is_a: GO:0030705 ! cytoskeleton-dependent intracellular transport
is_a: GO:0051650 ! establishment of vesicle localization
is_a: GO:1902580 ! single-organism cellular localization

[Term]
id: GO:0099519
name: dense core granule cytoskeletal trafficking
namespace: biological_process
def: "The directed movement of dense core granules along cytoskeletal fibers, such as microtubules or actin filaments." [GOC:kmv, PMID:23358451]
subset: goslim_synapse
synonym: "dense core granule cytoskeletal transport" EXACT []
synonym: "dense core vesicle cytoskeletal trafficking" EXACT []
is_a: GO:0099518 ! vesicle cytoskeletal trafficking
is_a: GO:1901950 ! dense core granule transport
relationship: occurs_in GO:0030424 ! axon

[Term]
id: GO:0099520
name: ion antiporter activity involved in regulation of presynaptic membrane potential
namespace: molecular_function
def: "Any ion antiporter activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential" [GOC:dos]
subset: goslim_synapse
synonym: "ion antiporter activity involved in regulation of pre-synaptic membrane potential" EXACT []
is_a: GO:0099516 ! ion antiporter activity
intersection_of: GO:0099516 ! ion antiporter activity
intersection_of: part_of GO:0099505 ! regulation of presynaptic membrane potential
relationship: occurs_in GO:0042734 ! presynaptic membrane
relationship: part_of GO:0099505 ! regulation of presynaptic membrane potential

[Term]
id: GO:0099521
name: ATPase coupled ion transmembrane transporter activity involved in regulation of presynaptic membrane potential
namespace: molecular_function
def: "Any ATPase coupled ion transmembrane transporter activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential. " [GOC:dos]
subset: goslim_synapse
synonym: "ATPase coupled ion transmembrane transporter activity involved in regulation of pre-synaptic membrane potential" EXACT []
synonym: "ATPase-coupled ion transmembrane transporter activity involved in regulation of presynaptic membrane potential" EXACT []
is_a: GO:0042625 ! ATPase coupled ion transmembrane transporter activity
intersection_of: GO:0042625 ! ATPase coupled ion transmembrane transporter activity
intersection_of: part_of GO:0099505 ! regulation of presynaptic membrane potential
relationship: occurs_in GO:0042734 ! presynaptic membrane
relationship: part_of GO:0099505 ! regulation of presynaptic membrane potential

[Term]
id: GO:0099522
name: region of cytosol
namespace: cellular_component
def: "Any (proper) part of the cytosol of a single cell of sufficient size to still be considered cytosol" [GOC:dos]
is_a: GO:0005829 ! cytosol
is_a: GO:0044445 ! cytosolic part
intersection_of: GO:0005829 ! cytosol
intersection_of: part_of GO:0005829 ! cytosol
relationship: part_of GO:0005829 ! cytosol

[Term]
id: GO:0099523
name: presynaptic cytosol
namespace: cellular_component
def: "The region of the cytosol consisting of all cytosol that is part of the presynapse." [GOC:dos]
subset: goslim_synapse
is_a: GO:0044456 ! synapse part
is_a: GO:0097458 ! neuron part
is_a: GO:0099522 ! region of cytosol
intersection_of: GO:0005829 ! cytosol
intersection_of: part_of GO:0005829 ! cytosol
intersection_of: part_of GO:0098793 ! presynapse
relationship: part_of GO:0005829 ! cytosol
relationship: part_of GO:0098793 ! presynapse

[Term]
id: GO:0099524
name: postsynaptic cytosol
namespace: cellular_component
def: "The region of the cytosol consisting of all cytosol that is part of the postsynapse." [GOC:dos]
subset: goslim_synapse
is_a: GO:0044456 ! synapse part
is_a: GO:0099522 ! region of cytosol
intersection_of: GO:0005829 ! cytosol
intersection_of: part_of GO:0005829 ! cytosol
intersection_of: part_of GO:0098794 ! postsynapse
relationship: part_of GO:0005829 ! cytosol
relationship: part_of GO:0098794 ! postsynapse

[Term]
id: GO:0099525
name: presynaptic dense core granule exocytosis
namespace: biological_process
def: "The secretion of molecules (e.g. neuropeptides and neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense in response to increased presynaptic cytosolic calcium levels." [PMID:17553987, PMID:24653208]
subset: goslim_synapse
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0099643 ! signal release from synapse
is_a: GO:1990504 ! dense core granule exocytosis
relationship: occurs_in GO:0098793 ! presynapse
relationship: part_of GO:0099536 ! synaptic signaling

[Term]
id: GO:0099526
name: presynapse to nucleus signaling pathway
namespace: biological_process
def: "A series of molecular signals that conveys information from the presynapse to the nucleus via cytoskeletal transport of a protein from a presynapse to the component to the nucleus where it affects biochemical processes that occur in the nucleus (e.g DNA transcription, mRNA splicing, or DNA/histone modifications)." [GOC:dos, PMID:24317321, PMID:25652077]
comment: This class does not cover the cellular machinery (motor proteins, cargo-recognition proteins) that transports the signaling protein along the cytoskeleton towards the nucleus. For these cases, annotate to the appropriate transport/trafficking term.
subset: gocheck_do_not_manually_annotate
subset: goslim_synapse
synonym: "presynaptic signaling to nucleus" EXACT []
is_a: GO:0007165 ! signal transduction

[Term]
id: GO:0099527
name: postsynapse to nucleus signaling pathway
namespace: biological_process
def: "A series of molecular signals that conveys information from the postsynapse to the nucleus via cytoskeletal transport of a protein from a postsynapse to the component to the nucleus where it affects biochemical processes that occur in the nucleus (e.g DNA transcription, mRNA splicing, or DNA/histone modifications)." [GOC:dos, PMID:24317321, PMID:25652077]
subset: goslim_synapse
synonym: "postsynaptic signaling to nucleus" EXACT []
is_a: GO:0098926 ! postsynaptic signal transduction

[Term]
id: GO:0099528
name: G-protein coupled neurotransmitter receptor activity
namespace: molecular_function
def: "Combining with a neurotransmitter and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:fj, GOC:mah]
is_a: GO:0004930 ! G-protein coupled receptor activity
is_a: GO:0030594 ! neurotransmitter receptor activity
relationship: part_of GO:0007186 ! G-protein coupled receptor signaling pathway

[Term]
id: GO:0099529
name: neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
namespace: molecular_function
def: "Neurotransmitter receptor activity occurring in the postsynaptic membrane that is involved in regulating postsynaptic membrane potential, either directly (ionotropic receptors) or indirectly (e.g. via GPCR activation of an ion channel.)" [GOC:dos]
subset: goslim_synapse
is_a: GO:0030594 ! neurotransmitter receptor activity
intersection_of: GO:0030594 ! neurotransmitter receptor activity
intersection_of: part_of GO:0060078 ! regulation of postsynaptic membrane potential
relationship: occurs_in GO:0045211 ! postsynaptic membrane
relationship: part_of GO:0060078 ! regulation of postsynaptic membrane potential
relationship: part_of GO:0099565 ! chemical synaptic transmission, postsynaptic

[Term]
id: GO:0099530
name: G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential
namespace: molecular_function
def: "G-protein coupled receptor activity occurring in the postsynaptic membrane that is part of a GPCR signaling pathway that positively regulates ion channel activity in the postsynaptic membrane." [GOC:dos]
subset: goslim_synapse
is_a: GO:0004930 ! G-protein coupled receptor activity
intersection_of: GO:0004930 ! G-protein coupled receptor activity
intersection_of: part_of GO:0060078 ! regulation of postsynaptic membrane potential
relationship: occurs_in GO:0045211 ! postsynaptic membrane
relationship: part_of GO:0060078 ! regulation of postsynaptic membrane potential

[Term]
id: GO:0099531
name: presynaptic process involved in synaptic transmission
namespace: biological_process
def: "The pathway leading to secretion of a neurotransmitter from the presynapse as part of synaptic transmission." [GOC:dos]
subset: goslim_synapse
is_a: GO:0008150 ! biological_process
intersection_of: GO:0008150 ! biological_process
intersection_of: occurs_in GO:0098793 ! presynapse
intersection_of: part_of GO:0007268 ! synaptic transmission
relationship: occurs_in GO:0098793 ! presynapse
relationship: part_of GO:0007268 ! synaptic transmission

[Term]
id: GO:0099532
name: synaptic vesicle processing via endosome
namespace: biological_process
def: "The process in which synaptic vesicles fuse to the presynaptic endosome followed by sorting of synaptic vesicle components and budding of new synaptic vesicles." [GOC:dos]
comment: This covers processing of synaptic vesicles trafficked to synapse as well as  of endocytosed vesicles as part of recycling.  It is there for not part of the synaptic vesicle cycle.
subset: goslim_synapse
is_a: GO:0016197 ! endosomal transport

[Term]
id: GO:0099533
name: positive regulation of presynaptic cytosolic calcium concentration
namespace: biological_process
def: "Any process that increases the concentration of calcium ions in the presynaptic cytosol." [GOC:dos]
subset: goslim_synapse
is_a: GO:0007204 ! positive regulation of cytosolic calcium ion concentration
is_a: GO:0099509 ! regulation of presynaptic cytosolic calcium ion concentration
intersection_of: GO:0007204 ! positive regulation of cytosolic calcium ion concentration
intersection_of: occurs_in GO:0098793 ! presynapse
relationship: occurs_in GO:0098793 ! presynapse

[Term]
id: GO:0099534
name: calcium ion binding involved in regulation of presynaptic cytosolic calcium levels
namespace: molecular_function
def: "The directed change of presynaptic cytosolic free calcium ion concentration in the cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in presynaptic cytosolic calcium concentrations." [PMID:24442513, PMID:26190970]
subset: goslim_synapse
synonym: "regulation of presynaptic cytosolic calcium ion concentration by calcium ion buffering" RELATED []
is_a: GO:0099510 ! calcium ion binding involved in regulation of cytosolic calcium ion concentration
intersection_of: GO:0005509 ! calcium ion binding
intersection_of: part_of GO:0099509 ! regulation of presynaptic cytosolic calcium ion concentration
relationship: occurs_in GO:0099523 ! presynaptic cytosol
relationship: part_of GO:0099509 ! regulation of presynaptic cytosolic calcium ion concentration

[Term]
id: GO:0099535
name: synapse associated extracellular matrix
namespace: cellular_component
def: "The extracellular matrix of the peri-synaptic space (the extracellular space adjacent to the synapse) and the synaptic cleft." [GOC:dos]
subset: goslim_synapse
synonym: "extra-synaptic extracellular matrix" EXACT []
synonym: "perisynaptic extracellular matrix" EXACT []
is_a: GO:0005578 ! proteinaceous extracellular matrix

[Term]
id: GO:0099536
name: synaptic signaling
namespace: biological_process
def: "Cell-cell signaling to or from a synapse." [GOC:dos]
subset: goslim_synapse
is_a: GO:0007267 ! cell-cell signaling

[Term]
id: GO:0099537
name: trans-synaptic signaling
namespace: biological_process
def: "Cell-cell signaling in either direction across the synaptic cleft." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099536 ! synaptic signaling

[Term]
id: GO:0099538
name: synaptic signaling via neuropeptide
namespace: biological_process
def: "Cell-cell signaling to or from a synapse, mediated by a peptide." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099536 ! synaptic signaling

[Term]
id: GO:0099539
name: neuropeptide secretion from presynapse
namespace: biological_process
def: "The secretion of neuropeptides contained within a dense core vesicle by fusion of the granule with the presynaptic membrane, stimulated by a rise in cytosolic calcium ion concentration." [PMID:17553987, PMID:24653208]
subset: goslim_synapse
synonym: "neuropeptide secretion from presynapse via dense core granule exocytosis" EXACT []
is_a: GO:0002790 ! peptide secretion
is_a: GO:0099525 ! presynaptic dense core granule exocytosis
relationship: occurs_in GO:0098793 ! presynapse
relationship: part_of GO:0099538 ! synaptic signaling via neuropeptide

[Term]
id: GO:0099540
name: trans-synaptic signaling by neuropeptide
namespace: biological_process
def: "Cell-cell signaling between presynapse and postsynapse mediated by a peptide ligand crossing the synaptic cleft." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099537 ! trans-synaptic signaling
is_a: GO:0099538 ! synaptic signaling via neuropeptide

[Term]
id: GO:0099541
name: trans-synaptic signaling by lipid
namespace: biological_process
def: "Cell-cell signaling from post to pre-synapse, across the synaptic cleft, mediated by a lipid." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099537 ! trans-synaptic signaling

[Term]
id: GO:0099542
name: trans-synaptic signaling by endocannabinoid
namespace: biological_process
def: "Cell-cell signaling in either direction across the synaptic cleft, mediated by an endocannabinoid ligand." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099541 ! trans-synaptic signaling by lipid

[Term]
id: GO:0099543
name: trans-synaptic signaling by soluble gas
namespace: biological_process
def: "Cell-cell signaling between presynapse and postsynapse mediated by a soluble gas ligand crossing the synaptic cleft." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099537 ! trans-synaptic signaling

[Term]
id: GO:0099544
name: perisynaptic space
namespace: cellular_component
def: "The extracellular region immediately adjacent to to a synapse." [GOC:dos]
subset: goslim_synapse
is_a: GO:0005576 ! extracellular region

[Term]
id: GO:0099545
name: trans-synaptic signaling by trans-synaptic complex
namespace: biological_process
def: "Cell-cell signaling between presynapse and postsynapse mediated by a trans-synaptic protein complex." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099537 ! trans-synaptic signaling

[Term]
id: GO:0099546
name: protein catabolic process, modulating synaptic transmission
namespace: biological_process
def: "Any catabolic process, occurring at a presynapse, that regulates synaptic transmission." [GOC:dos]
subset: goslim_synapse
is_a: GO:0030163 ! protein catabolic process
is_a: GO:0050804 ! modulation of synaptic transmission
intersection_of: GO:0030163 ! protein catabolic process
intersection_of: occurs_in GO:0045202 ! synapse
intersection_of: regulates GO:0007268 ! synaptic transmission
relationship: occurs_in GO:0045202 ! synapse
relationship: regulates GO:0007268 ! synaptic transmission

[Term]
id: GO:0099547
name: regulation of translation at synapse, modulating synaptic transmission
namespace: biological_process
def: "Any process that modulates synaptic transmission by regulating translation occurring at the synapse." [GOC:dos]
subset: goslim_synapse
is_a: GO:0006417 ! regulation of translation
is_a: GO:0050804 ! modulation of synaptic transmission
intersection_of: GO:0006417 ! regulation of translation
intersection_of: occurs_in GO:0045202 ! synapse
intersection_of: regulates GO:0007268 ! synaptic transmission
relationship: occurs_in GO:0045202 ! synapse
relationship: regulates GO:0007268 ! synaptic transmission

[Term]
id: GO:0099548
name: trans-synaptic signaling by nitric oxide
namespace: biological_process
def: "Cell-cell signaling between presynapse and postsynapse mediated by nitric oxide." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099543 ! trans-synaptic signaling by soluble gas

[Term]
id: GO:0099549
name: trans-synaptic signaling by carbon monoxide
namespace: biological_process
def: "Cell-cell signaling between presynapse and postsynapse mediated by carbon monoxide." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099543 ! trans-synaptic signaling by soluble gas

[Term]
id: GO:0099550
name: trans-synaptic signalling, modulating synaptic transmission
namespace: biological_process
def: "Cell-cell signaling between presynapse and postsynapse, across the synaptic cleft, that modulates the synaptic transmission properties of the synapse." [GOC:dos]
subset: goslim_synapse
is_a: GO:0050804 ! modulation of synaptic transmission
is_a: GO:0099537 ! trans-synaptic signaling
intersection_of: GO:0099537 ! trans-synaptic signaling
intersection_of: regulates GO:0007268 ! synaptic transmission
relationship: regulates GO:0007268 ! synaptic transmission

[Term]
id: GO:0099551
name: trans-synaptic signaling by neuropeptide, modulating synaptic transmission
namespace: biological_process
def: "Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of neuropeptide molecules, that modulates the synaptic transmission properties of the synapse." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099540 ! trans-synaptic signaling by neuropeptide
is_a: GO:0099550 ! trans-synaptic signalling, modulating synaptic transmission
relationship: regulates GO:0007268 ! synaptic transmission

[Term]
id: GO:0099552
name: trans-synaptic signaling by lipid, modulating synaptic transmission
namespace: biological_process
def: "Cell-cell signaling between presynapse and postsynapse, via the release and reception of lipid molecules, that modulates the synaptic transmission properties of the synapse." [GOC:dos, PMID:21531987]
subset: goslim_synapse
is_a: GO:0099541 ! trans-synaptic signaling by lipid
is_a: GO:0099550 ! trans-synaptic signalling, modulating synaptic transmission
relationship: regulates GO:0007268 ! synaptic transmission

[Term]
id: GO:0099553
name: trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
namespace: biological_process
def: "Cell-cell signaling between presynapse and postsynapse, via the release and reception of endocannabinoid ligands, that modulates the synaptic transmission properties of the synapse." [GOC:dos, PMID:21531987]
subset: goslim_synapse
is_a: GO:0099542 ! trans-synaptic signaling by endocannabinoid
is_a: GO:0099552 ! trans-synaptic signaling by lipid, modulating synaptic transmission
relationship: regulates GO:0007268 ! synaptic transmission

[Term]
id: GO:0099554
name: trans-synaptic signaling by soluble gas, modulating synaptic transmission
namespace: biological_process
def: "Cell-cell signaling between presynapse and postsynapse, via the release and reception of gaseous molecules, that modulates the synaptic transmission properties of the synapse." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099543 ! trans-synaptic signaling by soluble gas
is_a: GO:0099550 ! trans-synaptic signalling, modulating synaptic transmission
relationship: regulates GO:0007268 ! synaptic transmission

[Term]
id: GO:0099555
name: trans-synaptic signaling by nitric oxide, modulating synaptic transmission
namespace: biological_process
def: "Cell-cell signaling between presynapse and postsynapse, via the release and reception of nitric oxide molecules, that modulates the synaptic transmission properties of the synapse." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099548 ! trans-synaptic signaling by nitric oxide
is_a: GO:0099554 ! trans-synaptic signaling by soluble gas, modulating synaptic transmission
relationship: regulates GO:0007268 ! synaptic transmission

[Term]
id: GO:0099556
name: trans-synaptic signaling by carbon monoxide, modulating synaptic transmission
namespace: biological_process
def: "Cell-cell signaling between presynapse and postsynapse, via the release and reception of carbon monoxide molecules, that modulates the synaptic transmission properties of the synapse." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099549 ! trans-synaptic signaling by carbon monoxide
is_a: GO:0099554 ! trans-synaptic signaling by soluble gas, modulating synaptic transmission
relationship: regulates GO:0007268 ! synaptic transmission

[Term]
id: GO:0099557
name: trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission
namespace: biological_process
def: "Cell-cell signaling between presynapse and postsynapse, mediated by transynaptic protein complexes, that modulates the synaptic transmission properties of the synapse." [GOC:dos, PMID:19029886]
subset: goslim_synapse
is_a: GO:0099545 ! trans-synaptic signaling by trans-synaptic complex
is_a: GO:0099550 ! trans-synaptic signalling, modulating synaptic transmission
relationship: regulates GO:0007268 ! synaptic transmission

[Term]
id: GO:0099558
name: maintenance of synapse structure
namespace: biological_process
def: "A process that preserves the structural organistation and orientation of a synaptic cellular component such as the synaptic cytoskeleton and molecular scaffolds." [GOC:dos]
subset: goslim_synapse
is_a: GO:0043954 ! cellular component maintenance
is_a: GO:0050808 ! synapse organization

[Term]
id: GO:0099559
name: maintenance of alignment of postsynaptic density and presynaptic active zone
namespace: biological_process
def: "The process by which alignment between postsynaptic density and presynaptic active zone is maintained. " [GOC:dos]
subset: goslim_synapse
is_a: GO:0099558 ! maintenance of synapse structure

[Term]
id: GO:0099560
name: synaptic membrane adhesion
namespace: biological_process
def: "The attachment of presynaptic membrane to postsynaptic membrane via adhesion molecules that are at least partially embedded in the plasma membrane." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules
relationship: part_of GO:0050808 ! synapse organization

[Term]
id: GO:0099561
name: synaptic membrane adhesion to extracellular matrix
namespace: biological_process
def: "The binding of a synaptic membrane to the extracellular matrix via adhesion molecules." [GOC:dos]
subset: goslim_synapse
is_a: GO:0007160 ! cell-matrix adhesion
relationship: part_of GO:0050808 ! synapse organization

[Term]
id: GO:0099562
name: maintenance of postsynaptic density structure
namespace: biological_process
def: "A process which maintains the organization and the arrangement of proteins in the presynaptic density." [GOC:dos]
subset: goslim_synapse
is_a: GO:0097106 ! postsynaptic density organization
is_a: GO:0099558 ! maintenance of synapse structure

[Term]
id: GO:0099563
name: modification of synaptic structure
namespace: biological_process
def: "Any process that modifies the structure of a synapse." [GOC:dos]
comment: This class does not cover assembly or disassembly of synapses, only the modification/remodelling of existing ones.
subset: goslim_synapse
synonym: "synapse remodelling" EXACT []
is_a: GO:0050808 ! synapse organization

[Term]
id: GO:0099564
name: modification of synaptic structure, modulating synaptic transmission
namespace: biological_process
def: "Any process that modulates synaptic transmission via modification of the structure of the synapse." [GOC:dos]
subset: goslim_synapse
is_a: GO:0050804 ! modulation of synaptic transmission
is_a: GO:0099563 ! modification of synaptic structure
relationship: regulates GO:0007268 ! synaptic transmission

[Term]
id: GO:0099565
name: chemical synaptic transmission, postsynaptic
namespace: biological_process
def: "The part of synaptic transmission occurring in the post-synapse: a signal transduction pathway consisting of neurotransmitter receptor activation and its effects on postsynaptic membrane potential and the ionic composition of the postsynaptic cytosol." [GOC:dos]
subset: goslim_synapse
is_a: GO:1905114 ! cell surface receptor signaling pathway involved in cell-cell signaling
intersection_of: GO:0007166 ! cell surface receptor signaling pathway
intersection_of: occurs_in GO:0098794 ! postsynapse
intersection_of: part_of GO:0007268 ! synaptic transmission
relationship: occurs_in GO:0098794 ! postsynapse
relationship: part_of GO:0007268 ! synaptic transmission

[Term]
id: GO:0099566
name: regulation of postsynaptic cytosolic calcium ion concentration
namespace: biological_process
def: "Any process that regulates the concentration of calcium in the postsynaptic cytosol." [GOC:dos]
subset: goslim_synapse
is_a: GO:0051480 ! regulation of cytosolic calcium ion concentration

[Term]
id: GO:0099567
name: calcium ion binding involved in regulation of postsynaptic cytosolic calcium levels
namespace: molecular_function
def: "The directed change of free calcium ion concentration in the postsynaptic cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in postsynaptic cytosolic calcium concentrations." [PMID:24442513, PMID:26190970]
subset: goslim_synapse
synonym: "regulation of postsynaptic cytosolic calcium ion concentration by calcium ion buffering" RELATED []
is_a: GO:0099510 ! calcium ion binding involved in regulation of cytosolic calcium ion concentration
intersection_of: GO:0005509 ! calcium ion binding
intersection_of: part_of GO:0099566 ! regulation of postsynaptic cytosolic calcium ion concentration
relationship: occurs_in GO:0099524 ! postsynaptic cytosol
relationship: part_of GO:0099566 ! regulation of postsynaptic cytosolic calcium ion concentration

[Term]
id: GO:0099568
name: cytoplasmic region
namespace: cellular_component
def: "Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm\"" [GOC:dos]
is_a: GO:0005737 ! cytoplasm
is_a: GO:0044444 ! cytoplasmic part
intersection_of: GO:0005737 ! cytoplasm
intersection_of: part_of GO:0005737 ! cytoplasm
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0099569
name: presynaptic cytoskeleton
namespace: cellular_component
def: "The portion of the cytoskeleton contained within the presynapse." [GOC:dos]
subset: goslim_synapse
is_a: GO:0005856 ! cytoskeleton
is_a: GO:0044456 ! synapse part
is_a: GO:0097458 ! neuron part
intersection_of: GO:0005856 ! cytoskeleton
intersection_of: part_of GO:0098793 ! presynapse
relationship: part_of GO:0098793 ! presynapse

[Term]
id: GO:0099571
name: postsynaptic cytoskeleton
namespace: cellular_component
def: "The portion of the cytoskeleton contained within the postsynapse." [GOC:dos, PMID:19889835]
subset: goslim_synapse
is_a: GO:0005856 ! cytoskeleton
is_a: GO:0044456 ! synapse part
intersection_of: GO:0005856 ! cytoskeleton
intersection_of: part_of GO:0098794 ! postsynapse
relationship: part_of GO:0098794 ! postsynapse

[Term]
id: GO:0099572
name: postsynaptic specialization
namespace: cellular_component
def: "A dense network of proteins, adjacent to the postsynaptic membrane, consisting of anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components that spatially and functionally organize the neurotransmitter receptors at the synapse. " [PMID:22046028]
subset: goslim_synapse
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle
is_a: GO:0044456 ! synapse part
relationship: part_of GO:0098794 ! postsynapse

[Term]
id: GO:0099573
name: glutamatergic postsynaptic density
namespace: cellular_component
def: "The post-synaptic specialization of a glutamatergic excitatory synapse." [GOC:dos]
subset: goslim_synapse
is_a: GO:0097481 ! neuronal postsynaptic density

[Term]
id: GO:0099574
name: regulation of protein catabolic process at synapse, modulating synaptic transmission
namespace: biological_process
def: "Any process that modulates synaptic transmission by regulating a catabolic process occurring at the synapse." [GOC:dos]
subset: goslim_synapse
is_a: GO:0042176 ! regulation of protein catabolic process
is_a: GO:0050804 ! modulation of synaptic transmission
intersection_of: GO:0042176 ! regulation of protein catabolic process
intersection_of: occurs_in GO:0045202 ! synapse
intersection_of: regulates GO:0007268 ! synaptic transmission
relationship: occurs_in GO:0045202 ! synapse
relationship: regulates GO:0007268 ! synaptic transmission

[Term]
id: GO:0099575
name: regulation of protein catabolic process at presynapse, modulating synaptic transmission
namespace: biological_process
def: "Any process that modulates synaptic transmission by regulating a catabolic process occurring at a presynapse." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099574 ! regulation of protein catabolic process at synapse, modulating synaptic transmission
intersection_of: GO:0042176 ! regulation of protein catabolic process
intersection_of: occurs_in GO:0098793 ! presynapse
intersection_of: regulates GO:0007268 ! synaptic transmission
relationship: occurs_in GO:0098793 ! presynapse
relationship: regulates GO:0007268 ! synaptic transmission

[Term]
id: GO:0099576
name: regulation of protein catabolic process at postsynapse, modulating synaptic transmission
namespace: biological_process
def: "Any process that modulates synaptic transmission by regulating a catabolic process occurring at a postsynapse." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099574 ! regulation of protein catabolic process at synapse, modulating synaptic transmission
intersection_of: GO:0042176 ! regulation of protein catabolic process
intersection_of: occurs_in GO:0098794 ! postsynapse
intersection_of: regulates GO:0007268 ! synaptic transmission
relationship: occurs_in GO:0098794 ! postsynapse
relationship: regulates GO:0007268 ! synaptic transmission

[Term]
id: GO:0099577
name: regulation of translation at presynapse, modulating synaptic transmission
namespace: biological_process
def: "Any process that modulates synaptic transmission by regulating translation occurring at the presynapse." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099547 ! regulation of translation at synapse, modulating synaptic transmission
intersection_of: GO:0006417 ! regulation of translation
intersection_of: occurs_in GO:0098793 ! presynapse
intersection_of: regulates GO:0007268 ! synaptic transmission
relationship: occurs_in GO:0098793 ! presynapse
relationship: regulates GO:0007268 ! synaptic transmission

[Term]
id: GO:0099578
name: regulation of translation at postsynapse, modulating synaptic transmission
namespace: biological_process
def: "Any process that modulates synaptic transmission by regulating translation occurring at the postsynapse." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099547 ! regulation of translation at synapse, modulating synaptic transmission
intersection_of: GO:0006417 ! regulation of translation
intersection_of: occurs_in GO:0098794 ! postsynapse
intersection_of: regulates GO:0007268 ! synaptic transmission
relationship: occurs_in GO:0098794 ! postsynapse
relationship: regulates GO:0007268 ! synaptic transmission

[Term]
id: GO:0099579
name: G-protein coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
namespace: molecular_function
def: "G-protein coupled neurotransmitter receptor activity occurring in the postsynaptic membrane that is part of a GPCR signaling pathway that positively regulates ion channel activity in the postsynaptic membrane." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099528 ! G-protein coupled neurotransmitter receptor activity
is_a: GO:0099529 ! neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
is_a: GO:0099530 ! G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential
intersection_of: GO:0099528 ! G-protein coupled neurotransmitter receptor activity
intersection_of: part_of GO:0060078 ! regulation of postsynaptic membrane potential
relationship: occurs_in GO:0045211 ! postsynaptic membrane
relationship: part_of GO:0060078 ! regulation of postsynaptic membrane potential

[Term]
id: GO:0099580
name: ion antiporter activity involved in regulation of postsynaptic membrane potential
namespace: molecular_function
def: "Any ion antiporter activity, occurring in the postsynaptic membrane, that is involved in regulation of postsynaptic membrane potential" [GOC:dos]
subset: goslim_synapse
synonym: "ion antiporter activity involved in regulation of post-synaptic membrane potential" EXACT []
is_a: GO:0099516 ! ion antiporter activity
intersection_of: GO:0099516 ! ion antiporter activity
intersection_of: part_of GO:0060078 ! regulation of postsynaptic membrane potential
relationship: occurs_in GO:0045211 ! postsynaptic membrane
relationship: part_of GO:0060078 ! regulation of postsynaptic membrane potential

[Term]
id: GO:0099581
name: ATPase coupled ion transmembrane transporter activity involved in regulation of postsynaptic membrane potential
namespace: molecular_function
def: "Any ATPase coupled ion transmembrane transporter activity, occurring in the postsynaptic membrane, that is involved in regulation of postsynaptic membrane potential. " [GOC:dos]
subset: goslim_synapse
synonym: "ATPase coupled ion transmembrane transporter activity involved in regulation of post-synaptic membrane potential" EXACT []
synonym: "ATPase-coupled ion transmembrane transporter activity involved in regulation of postsynaptic membrane potential" EXACT []
is_a: GO:0042625 ! ATPase coupled ion transmembrane transporter activity
intersection_of: GO:0042625 ! ATPase coupled ion transmembrane transporter activity
intersection_of: part_of GO:0060078 ! regulation of postsynaptic membrane potential
relationship: occurs_in GO:0045211 ! postsynaptic membrane
relationship: part_of GO:0060078 ! regulation of postsynaptic membrane potential

[Term]
id: GO:0099582
name: neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium levels
namespace: molecular_function
def: "Any neurotransmitter receptor activity that is involved in regulating the concentration of calcium in the presynaptic cytosol." [GOC:dos]
subset: goslim_synapse
is_a: GO:0030594 ! neurotransmitter receptor activity
intersection_of: GO:0030594 ! neurotransmitter receptor activity
intersection_of: part_of GO:0099509 ! regulation of presynaptic cytosolic calcium ion concentration
relationship: occurs_in GO:0042734 ! presynaptic membrane
relationship: part_of GO:0099509 ! regulation of presynaptic cytosolic calcium ion concentration

[Term]
id: GO:0099583
name: neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium levels
namespace: molecular_function
def: "Any neurotransmitter receptor activity that is involved in regulating the concentration of calcium in the presynaptic cytosol." [GOC:dos]
subset: goslim_synapse
is_a: GO:0030594 ! neurotransmitter receptor activity
intersection_of: GO:0030594 ! neurotransmitter receptor activity
intersection_of: part_of GO:0099566 ! regulation of postsynaptic cytosolic calcium ion concentration
relationship: occurs_in GO:0045211 ! postsynaptic membrane
relationship: part_of GO:0099565 ! chemical synaptic transmission, postsynaptic
relationship: part_of GO:0099566 ! regulation of postsynaptic cytosolic calcium ion concentration

[Term]
id: GO:0099585
name: release of sequestered calcium ion into presynaptic cytosol
namespace: biological_process
def: "The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the presynaptic cytosol." [GOC:dos]
subset: goslim_synapse
is_a: GO:0051209 ! release of sequestered calcium ion into cytosol
is_a: GO:0099533 ! positive regulation of presynaptic cytosolic calcium concentration
relationship: occurs_in GO:0098793 ! presynapse

[Term]
id: GO:0099586
name: release of sequestered calcium ion into postsynaptic cytosol
namespace: biological_process
def: "The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the postsynaptic cytosol." [GOC:dos]
subset: goslim_synapse
is_a: GO:0051209 ! release of sequestered calcium ion into cytosol
is_a: GO:0099588 ! positive regulation of postsynaptic cytosolic calcium concentration
relationship: occurs_in GO:0098794 ! postsynapse

[Term]
id: GO:0099587
name: inorganic ion import into cell
namespace: biological_process
def: "The directed movement of inorganic ions from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [GOC:dos]
is_a: GO:0006811 ! ion transport
is_a: GO:0098657 ! import into cell

[Term]
id: GO:0099588
name: positive regulation of postsynaptic cytosolic calcium concentration
namespace: biological_process
def: "Any process that increases the concentration of calcium ions in the postsynaptic cytosol." [GOC:dos]
subset: goslim_synapse
is_a: GO:0007204 ! positive regulation of cytosolic calcium ion concentration
intersection_of: GO:0007204 ! positive regulation of cytosolic calcium ion concentration
intersection_of: occurs_in GO:0098794 ! postsynapse
relationship: occurs_in GO:0098794 ! postsynapse

[Term]
id: GO:0099589
name: serotonin receptor activity
namespace: molecular_function
def: "Combining with the biogenic amine serotonin and transmitting a signal across a membrane by activating some effector activity. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates." [GOC:dos]
is_a: GO:0004888 ! transmembrane signaling receptor activity

[Term]
id: GO:0099590
name: neurotransmitter receptor internalization
namespace: biological_process
def: "A receptor-mediated endocytosis process that results in the internalization of a neurotransmitter receptor from the postsynaptic membrane endocytic zone into an endocytic vesicle." [GOC:dos]
subset: goslim_synapse
synonym: "postsynaptic neurotransmitter receptor endocytosis" EXACT []
is_a: GO:0031623 ! receptor internalization
relationship: part_of GO:0099627 ! neurotransmitter receptor cycle

[Term]
id: GO:0099592
name: endocytosed synaptic vesicle processing via endosome
namespace: biological_process
def: "The process in which endocytosed synaptic vesicles fuse to the presynaptic endosome followed by sorting of synaptic vesicle components and budding of new synaptic vesicles." [GOC:dos]
subset: goslim_synapse
synonym: "synaptic vesicle processing via endosome involved in synaptic vesicle recycling" EXACT []
is_a: GO:0016482 ! cytosolic transport
is_a: GO:0099532 ! synaptic vesicle processing via endosome
intersection_of: GO:0099532 ! synaptic vesicle processing via endosome
intersection_of: part_of GO:0036466 ! synaptic vesicle recycling via endosome
relationship: part_of GO:0036466 ! synaptic vesicle recycling via endosome

[Term]
id: GO:0099593
name: endocytosed synaptic vesicle to endosome fusion
namespace: biological_process
def: "Fusion of an endocytosed synaptic vesicle with an endosome." [GOC:dos]
subset: goslim_synapse
is_a: GO:0016189 ! synaptic vesicle to endosome fusion
intersection_of: GO:0016189 ! synaptic vesicle to endosome fusion
intersection_of: part_of GO:0036466 ! synaptic vesicle recycling via endosome
relationship: part_of GO:0036466 ! synaptic vesicle recycling via endosome

[Term]
id: GO:0099600
name: transmembrane receptor activity
namespace: molecular_function
def: "Combining with an extracellular or intracellular signal and transmitting a signal from one side of the membrane to the other." [GOC:dos]
comment: This class covers receptors invovled in signal transduction and those that are not.  Ligand gated ion channels are only considered to be involved in signal transduction if the ligand they transport acts as a second messenger.
is_a: GO:0004872 ! receptor activity

[Term]
id: GO:0099601
name: regulation of neurotransmitter receptor activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neurotransmitter receptor activity. Modulation may be via an effect on ligand affinity, or effector funtion such as ion selectivity or pore opening/closing in ionotropic receptors." [GOC:dos]
subset: goslim_synapse
is_a: GO:0010469 ! regulation of receptor activity
is_a: GO:0050804 ! modulation of synaptic transmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030594 ! neurotransmitter receptor activity
relationship: regulates GO:0030594 ! neurotransmitter receptor activity

[Term]
id: GO:0099602
name: neurotransmitter receptor regulator activity
namespace: molecular_function
def: "A molecular function that directly (via physical interaction or direct modification) activates, inhibits or otherwise modulates the activity of a neurotransmitter receptor. Modulation of activity includes changes in desensitization rate, ligand affinity, ion selectivity and pore-opening/closing." [GOC:dos, PMID:12740117, PMID:25172949]
is_a: GO:0030545 ! receptor regulator activity
relationship: part_of GO:0099601 ! regulation of neurotransmitter receptor activity

[Term]
id: GO:0099604
name: ligand-gated calcium channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a calcium ions by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:dos]
is_a: GO:0004888 ! transmembrane signaling receptor activity
is_a: GO:0005262 ! calcium channel activity
is_a: GO:0015276 ! ligand-gated ion channel activity
relationship: part_of GO:0019722 ! calcium-mediated signaling

[Term]
id: GO:0099605
name: regulation of action potential firing rate
namespace: biological_process
def: "Any process that regulates the frequency of action potentials in a spike train." [ISBN:978-0071390118]
is_a: GO:0098900 ! regulation of action potential

[Term]
id: GO:0099606
name: microtubule plus-end directed mitotic chromosome migration
namespace: biological_process
def: "The cell cycle process in which chromosomes that are laterally attached to one or more mitotic spindle microtubules migrate towards the spindle equator via plus-end-directed movement along the microtubules. This process is part of mitotic metaphase plate congression." [GOC:dos, PMID:26258632, PMID:26705896]
synonym: "plus-end directed chromosome gliding" EXACT [PMID:26258632]
is_a: GO:0010970 ! establishment of localization by movement along microtubule
is_a: GO:0051303 ! establishment of chromosome localization
is_a: GO:1902580 ! single-organism cellular localization
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:0007080 ! mitotic metaphase plate congression

[Term]
id: GO:0099607
name: lateral attachment of mitotic spindle microtubules to kinetochore
namespace: biological_process
def: "The cell cycle process in which sister chromatids become laterally attached to spindle microtubules as part of mitotic metaphase plate congression. Attachment precedes migration along microtubules towards the spindle equator (metaphase plate)." [PMID:26258632, PMID:26705896]
is_a: GO:0051315 ! attachment of mitotic spindle microtubules to kinetochore
relationship: part_of GO:0007080 ! mitotic metaphase plate congression

[Term]
id: GO:0099608
name: regulation of action potential firing pattern
namespace: biological_process
def: "Any process that regulates the temporal pattern of a sequence of action potentials in a neuron." [ISBN:978-0071390118]
synonym: "spike train sculpting" EXACT []
is_a: GO:0098900 ! regulation of action potential
relationship: regulates GO:0098874 ! spike train

[Term]
id: GO:0099609
name: microtubule lateral binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the side of a microtubule." [GOC:dos]
is_a: GO:0008017 ! microtubule binding

[Term]
id: GO:0099610
name: action potential initiation
namespace: biological_process
def: "The initiating cycle of an action potential. In vertebrate neurons this typically occurs at an axon hillock. Not all initiated axon potentials propagate." [ISBN:978-0071390118, PMID:19439602]
synonym: "action potential firing" EXACT []
synonym: "action potential triggering" EXACT []
is_a: GO:0001508 ! action potential

[Term]
id: GO:0099611
name: regulation of action potential firing threshold
namespace: biological_process
def: "Any process that regulates the potential at which an axon potential is triggered." [ISBN:978-0071390118]
is_a: GO:0098900 ! regulation of action potential

[Term]
id: GO:0099612
name: protein localization to axon
namespace: biological_process
def: "A process in which a protein is transported to or maintained in a location within an axon." [GOC:dos, PMID:26157139]
is_a: GO:0008104 ! protein localization

[Term]
id: GO:0099613
name: protein targeting to cell wall
namespace: biological_process
def: "The process of directing proteins towards the cell-wall." [ISBN:0716731363]
is_a: GO:0006605 ! protein targeting
is_a: GO:1902580 ! single-organism cellular localization
is_a: GO:1990778 ! protein localization to cell periphery

[Term]
id: GO:0099614
name: protein targeting to spore cell wall
namespace: biological_process
def: "The process of directing proteins towards the spore cell-wall." [GOC:dos]
is_a: GO:0099613 ! protein targeting to cell wall

[Term]
id: GO:0099615
name: (D)-2-hydroxyglutarate-pyruvate transhydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-2-hydroxyglutarate + pyruvate = alpha-ketoglutarate + D-lactate, with FAD functioning as an intermediate hydrogen acceptor." [PMID:26774271]
synonym: "D-2HG-pyruvate transhydrogenase activity" EXACT []
synonym: "R-2-hydroxyglutarate alpha-pyruvate transhydrogenase activity" EXACT []
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0099616
name: extrinsic component of matrix side of mitochondrial inner membrane
namespace: cellular_component
def: "The component of the matrix side of the mitochondrial inner membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.\"\n" [GOC:dos]
is_a: GO:0031314 ! extrinsic component of mitochondrial inner membrane
intersection_of: GO:0019898 ! extrinsic component of membrane
intersection_of: part_of GO:0099617 ! matrix side of mitochondrial inner membrane
relationship: part_of GO:0099617 ! matrix side of mitochondrial inner membrane

[Term]
id: GO:0099617
name: matrix side of mitochondrial inner membrane
namespace: cellular_component
def: "The side (leaflet) of the mitochondrial inner membrane that faces the matrix." [GOC:dos]
is_a: GO:0044455 ! mitochondrial membrane part
is_a: GO:0098576 ! lumenal side of membrane
relationship: part_of GO:0005743 ! mitochondrial inner membrane

[Term]
id: GO:0099618
name: UDP-glucuronic acid dehydrogenase activity
namespace: molecular_function
def: "Catalytis of the reaction: UDP-glucuronate + NAD+ = UDP-beta-L-threo-pentapyranos-4-ulose + CO2 + NADH + H+" [GOC:al, GOC:dos]
synonym: "UDP-GlcUA decarboxylase activity" EXACT []
xref: EC:1.1.1.305
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0099619
name: UDP-4-amino-4-deoxy-L-arabinose formyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinopyranose = 5,6,7,8-tetrahydrofolate + UDP-4-deoxy-4-formamido-beta-L-arabinopyranose " [PMID:15695810, PMID:15807526, PMID:15809294, PMID:15939024, PMID:17928292]
synonym: "10-formyltetrahydrofolate:UDP-4-amino-4-deoxy-beta-L-arabinose N-formyltransferase activity" EXACT []
synonym: "ArnAFT activity" EXACT []
synonym: "UDP-L-Ara4N formyltransferase activity" EXACT []
xref: EC:2.1.2.13
is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity

[Term]
id: GO:0099620
name: UDP-4-amino-4-deoxy-L-arabinose aminotransferase
namespace: molecular_function
def: "Catalysis of the reaction: UDP-4-amino-4-deoxy-beta-L-arabinopyranose + 2-oxoglutarate = UDP-beta-L-threo-pentapyranos-4-ulose + L-glutamate" [GOC:al, GOC:dos, PMID:12429098, PMID:12704196]
synonym: "UDP-(beta-L-threo-pentapyranosyl-4''-ulose diphosphate) aminotransferase" EXACT []
synonym: "UDP-4-amino-4-deoxy-beta-L-arabinose:2-oxoglutarate aminotransferase" EXACT []
synonym: "UDP-4-amino-4-deoxy-L-arabinose---oxoglutarate aminotransferase" EXACT []
synonym: "UDP-Ara4O aminotransferase" EXACT []
synonym: "UDP-L-Ara4N transaminase" EXACT []
xref: EC:12.6.1.87
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0099621
name: undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-4-deoxy-4-formamido-beta-L-arabinopyranose + ditrans,octacis-undecaprenyl phosphate = UDP + 4-deoxy-4-formamido-alpha-L-arabinopyranosyl ditrans,octacis-undecaprenyl phosphate." [GOC:al, GOC:dos, PMID:11706007, PMID:15695810]
synonym: "Ara4FN transferase activity" EXACT []
synonym: "undecaprenyl-phosphate Ara4FN transferase activity" EXACT []
xref: EC:2.6.1.87
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0099622
name: cardiac muscle cell membrane repolarization
namespace: biological_process
def: "The process in which ions are transported across the plasma membrane of a cardiac muscle cell such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential." [GOC:BHF]
is_a: GO:0086009 ! membrane repolarization

[Term]
id: GO:0099623
name: regulation of cardiac muscle cell membrane repolarization
namespace: biological_process
def: "Any process that modulates the establishment or extent of a change in membrane potential in the polarizing direction towards the resting potential in a cardiomyocyte." [GOC:BHF, GOC:dos, GOC:rl]
synonym: "heart repolarization" RELATED []
synonym: "regulation of cardiac muscle cell repolarization" EXACT []
synonym: "regulation of cardiomyocyte membrane repolarization" EXACT []
is_a: GO:0060306 ! regulation of membrane repolarization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0099622 ! cardiac muscle cell membrane repolarization
relationship: regulates GO:0099622 ! cardiac muscle cell membrane repolarization

[Term]
id: GO:0099624
name: atrial cardiac muscle cell membrane repolarization
namespace: biological_process
def: "The process in which ions are transported across the plasma membrane of a cardiac muscle cell such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential." [GOC:BHF]
is_a: GO:0099622 ! cardiac muscle cell membrane repolarization

[Term]
id: GO:0099625
name: ventricular cardiac muscle cell membrane repolarization
namespace: biological_process
def: "The process in which ions are transported across the plasma membrane of a ventricular cardiac muscle cell such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0099622 ! cardiac muscle cell membrane repolarization

[Term]
id: GO:0099626
name: voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels
namespace: molecular_function
def: "Regulation of presynaptic cytosolic calcium ion concentrations via the directed movement of calcium ions across the plasma-membrane into the cytosol via the action of a voltage-gated calcium ion channel.  This is the first step in synaptic transmission" [GOC:dos]
subset: goslim_synapse
is_a: GO:0099511 ! voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels
intersection_of: GO:0005245 ! voltage-gated calcium channel activity
intersection_of: part_of GO:0099509 ! regulation of presynaptic cytosolic calcium ion concentration
relationship: occurs_in GO:0098793 ! presynapse
relationship: part_of GO:0099509 ! regulation of presynaptic cytosolic calcium ion concentration

[Term]
id: GO:0099627
name: neurotransmitter receptor cycle
namespace: biological_process
def: "The process during which neurotransmitter receptors, anchored in some region of the synaptic membrane, are recycled via the endosome.  This cycle includes release from anchoring, diffusion in the synaptic membrane to an endocytic region, endocytosis, transport to the endosome, recycling in the endosome,  transport back the synaptic membrane and subsequent anchoring (trapping)." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099637 ! neurotransmitter receptor transport

[Term]
id: GO:0099628
name: neurotransmitter receptor diffusion trapping
namespace: biological_process
def: "The process by which diffusing neurotransmitter receptor becomes trapped at the postsynaptic speicalization membrane. This is typically due to interaction with components of the post-specialization." [PMID:18832033]
subset: goslim_synapse
is_a: GO:0051668 ! localization within membrane
is_a: GO:0099645 ! neurotransmitter receptor localization to postsynaptic specialization membrane
relationship: occurs_in GO:0045211 ! postsynaptic membrane

[Term]
id: GO:0099629
name: postsynaptic specialization of inhibitory synapse
namespace: cellular_component
def: "A network of proteins, adjacent to the postsynaptic membrane of an inhibitory synapse, consisting of anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components that spatially and functionally organize the neurotransmitter receptors at the synapse. This structure is not as thick or electron dense as the postsynaptic densities found in excitatory synapses." [PMID:18832033]
subset: goslim_synapse
synonym: "postsynaptic density of inhibitory synapse" EXACT [PMID:18832033]
is_a: GO:0099572 ! postsynaptic specialization
intersection_of: GO:0099572 ! postsynaptic specialization
intersection_of: part_of GO:0060077 ! inhibitory synapse
relationship: part_of GO:0060077 ! inhibitory synapse

[Term]
id: GO:0099630
name: postsynaptic neurotransmitter receptor cycle
namespace: biological_process
def: "The process during which neurotransmitter receptors in the postsynaptic specialization membrane are recycled via the endosome. This cycle includes release from anchoring (trapping), diffusion in the synaptic membrane to the postsynaptic endocytic region, endocytosis, transport to the endosome, recycling in the endosome,  transport back the synaptic membrane and subsequent trapping in the postsynaptic specialization membrane." [PMID:18832033]
subset: goslim_synapse
is_a: GO:0099627 ! neurotransmitter receptor cycle

[Term]
id: GO:0099631
name: postsynaptic endocytic zone, cytoplasmic component
namespace: cellular_component
def: "The cytoplasmic component of the postsynaptic endocytic zone." [GOC:dos]
subset: goslim_synapse
synonym: "cortex of postsynaptic endocytic zone" EXACT []
is_a: GO:0044456 ! synapse part
is_a: GO:0099738 ! cell cortex region
relationship: part_of GO:0098843 ! postsynaptic endocytic zone

[Term]
id: GO:0099632
name: protein transport within plasma membrane
namespace: biological_process
def: "A process in which protein is transported from one region of the plasma membrane to another." [GOC:dos]
is_a: GO:0032594 ! protein transport within lipid bilayer
is_a: GO:0072659 ! protein localization to plasma membrane
is_a: GO:0090002 ! establishment of protein localization to plasma membrane
relationship: occurs_in GO:0005886 ! plasma membrane

[Term]
id: GO:0099633
name: protein localization to postsynaptic specialization membrane
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within the membrane adjacent to a postsynaptic specialization (e.g. post synaptic density)." [GOC:dos]
synonym: "protein localisation in postsynaptic specialization membrane" EXACT [GOC:TermGenie]
is_a: GO:1903539 ! protein localization to postsynaptic membrane

[Term]
id: GO:0099634
name: postsynaptic specialization membrane
namespace: cellular_component
def: "The region of the postsynaptic membrane adjacent to the postsynaptic specialization." [GOC:dos]
subset: goslim_synapse
is_a: GO:0097060 ! synaptic membrane
relationship: part_of GO:0045211 ! postsynaptic membrane

[Term]
id: GO:0099635
name: voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels
namespace: molecular_function
def: "Regulation of presynaptic cytosolic calcium ion concentrations via the directed movement of calcium ions across the plasma-membrane into the cytosol via the action of a voltage-gated calcium ion channel.  This is the first step in synaptic transmission" [GOC:dos]
subset: goslim_synapse
is_a: GO:0099626 ! voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels
intersection_of: GO:0005245 ! voltage-gated calcium channel activity
intersection_of: part_of GO:0099533 ! positive regulation of presynaptic cytosolic calcium concentration
relationship: occurs_in GO:0098793 ! presynapse
relationship: part_of GO:0099533 ! positive regulation of presynaptic cytosolic calcium concentration
relationship: part_of GO:0099703 ! induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration

[Term]
id: GO:0099636
name: cytoplasmic streaming
namespace: biological_process
def: "The directed flow of cytosol (the liquid component of the cytoplasm) and the organelles it contains." [GOC:dos, Wikipedia:Cytoplasmic_streaming&oldid=706214009]
xref: Wikipedia:Cytoplasmic_streaming
is_a: GO:0016482 ! cytosolic transport

[Term]
id: GO:0099637
name: neurotransmitter receptor transport
namespace: biological_process
def: "The directed movement of neurotransmitter receptors." [GOC:dos]
is_a: GO:0015031 ! protein transport

[Term]
id: GO:0099638
name: endosome to plasma membrane protein transport
namespace: biological_process
def: "The directed movement of proteins from the endosome to the plasma membrane in transport vesicles." [GOC:dos]
is_a: GO:0006886 ! intracellular protein transport
is_a: GO:0072659 ! protein localization to plasma membrane
is_a: GO:0090002 ! establishment of protein localization to plasma membrane
is_a: GO:1990126 ! retrograde transport, endosome to plasma membrane

[Term]
id: GO:0099639
name: neurotransmitter receptor transport, endosome to plasma membrane
namespace: biological_process
def: "The directed movement of neurotransmitter receptor from the endosome to the plasma membrane in transport vesicles." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099638 ! endosome to plasma membrane protein transport
relationship: part_of GO:0099627 ! neurotransmitter receptor cycle

[Term]
id: GO:0099640
name: axo-dendritic protein transport
namespace: biological_process
def: "The directed movement of proteins along microtubules in neuron projections." [ISBN:0815316194]
subset: goslim_synapse
synonym: "axonal protein transport" NARROW []
is_a: GO:0008088 ! axo-dendritic transport
is_a: GO:0098840 ! protein transport along microtubule
relationship: occurs_in GO:0043005 ! neuron projection

[Term]
id: GO:0099641
name: anterograde axonal protein transport
namespace: biological_process
def: "The directed movement of proteins along microtubules from the cell body toward the cell periphery in nerve cell axons." [GOC:dos]
subset: goslim_synapse
synonym: "anterograde axon cargo transport" EXACT []
is_a: GO:0008089 ! anterograde axonal transport
is_a: GO:0035418 ! protein localization to synapse
is_a: GO:0099640 ! axo-dendritic protein transport
relationship: occurs_in GO:1904115 ! axon cytoplasm

[Term]
id: GO:0099642
name: retrograde axonal protein transport
namespace: biological_process
def: "The directed movement of proteins along microtubules from the cell periphery toward the cell body in nerve cell axons." [ISBN:0815316194]
subset: goslim_synapse
synonym: "retrograde axon cargo transport" EXACT []
is_a: GO:0008090 ! retrograde axonal transport
is_a: GO:0099640 ! axo-dendritic protein transport
relationship: occurs_in GO:1904115 ! axon cytoplasm

[Term]
id: GO:0099643
name: signal release from synapse
namespace: biological_process
def: "Any signal release from a synapse." [GOC:dos]
subset: goslim_synapse
is_a: GO:0023061 ! signal release
intersection_of: GO:0023061 ! signal release
intersection_of: occurs_in GO:0045202 ! synapse
relationship: occurs_in GO:0045202 ! synapse
relationship: part_of GO:0099536 ! synaptic signaling

[Term]
id: GO:0099644
name: protein localization to presynaptic membrane
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a presynaptic membrane." [GOC:dos]
synonym: "protein localisation in presynaptic membrane" EXACT [GOC:TermGenie]
synonym: "protein localisation to presynaptic membrane" EXACT [GOC:TermGenie]
synonym: "protein localization in presynaptic membrane" EXACT [GOC:TermGenie]
is_a: GO:0035418 ! protein localization to synapse
is_a: GO:0072659 ! protein localization to plasma membrane

[Term]
id: GO:0099645
name: neurotransmitter receptor localization to postsynaptic specialization membrane
namespace: biological_process
def: "A process in which a neurotransmitter is transported to, or maintained in, a location within the membrane adjacent to a postsynaptic specialization (e.g. post synaptic density)." [GOC:dos]
subset: goslim_synapse
synonym: "neurotransmitter receptor localisation in postsynaptic specialization membrane" EXACT [GOC:TermGenie]
is_a: GO:0099633 ! protein localization to postsynaptic specialization membrane
relationship: part_of GO:0099627 ! neurotransmitter receptor cycle

[Term]
id: GO:0099646
name: neurotransmitter receptor transport, plasma membrane to endosome
namespace: biological_process
def: "Vesicle mediated transport of a neurotransmitter receptor vesicle from the plasma membrane to the endosome." [GOC:dos]
subset: goslim_synapse
is_a: GO:0048227 ! plasma membrane to endosome transport
relationship: part_of GO:0099627 ! neurotransmitter receptor cycle

[Term]
id: GO:0099703
name: induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration
namespace: biological_process
def: "The induction of synaptic vesicle release by any process that leads to a rise in intracellular calcium ion concentration at the presynapse.  This is the first step in synaptic transmission." [GOC:dos, ISBN:9780071120005]
subset: goslim_synapse
is_a: GO:0099531 ! presynaptic process involved in synaptic transmission
is_a: GO:0099533 ! positive regulation of presynaptic cytosolic calcium concentration
is_a: GO:2000302 ! positive regulation of synaptic vesicle exocytosis
intersection_of: GO:0099533 ! positive regulation of presynaptic cytosolic calcium concentration
intersection_of: positively_regulates GO:0016079 ! synaptic vesicle exocytosis
relationship: occurs_in GO:0098793 ! presynapse
relationship: part_of GO:0007268 ! synaptic transmission
relationship: positively_regulates GO:0016079 ! synaptic vesicle exocytosis

[Term]
id: GO:0099738
name: cell cortex region
namespace: cellular_component
def: "The complete extent of cell cortex that underlies some some region of the plasma membrane" [GOC:dos]
is_a: GO:0005938 ! cell cortex
is_a: GO:0044448 ! cell cortex part
intersection_of: GO:0005938 ! cell cortex
intersection_of: part_of GO:0005938 ! cell cortex
relationship: part_of GO:0005938 ! cell cortex

[Term]
id: GO:0100001
name: regulation of skeletal muscle contraction by action potential
namespace: biological_process
def: "Any action potential process that regulates skeletal muscle contraction" [GOC:cjm, GOC:obol]
is_a: GO:0001508 ! action potential
is_a: GO:0014819 ! regulation of skeletal muscle contraction
intersection_of: GO:0001508 ! action potential
intersection_of: regulates GO:0003009 ! skeletal muscle contraction
relationship: regulates GO:0003009 ! skeletal muscle contraction
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100002
name: negative regulation of protein kinase activity by protein phosphorylation
namespace: biological_process
def: "Any protein phosphorylation process that negatively_regulates protein kinase activity" [GOC:cjm, GOC:obol]
is_a: GO:0006468 ! protein phosphorylation
is_a: GO:0006469 ! negative regulation of protein kinase activity
intersection_of: GO:0006468 ! protein phosphorylation
intersection_of: negatively_regulates GO:0004672 ! protein kinase activity
relationship: negatively_regulates GO:0004672 ! protein kinase activity
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100003
name: positive regulation of sodium ion transport by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that positively_regulates sodium ion transport" [GOC:cjm, GOC:obol]
is_a: GO:0010765 ! positive regulation of sodium ion transport
is_a: GO:0100020 ! regulation of transport by transcription from RNA polymerase II promoter
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: positively_regulates GO:0006814 ! sodium ion transport
relationship: positively_regulates GO:0006814 ! sodium ion transport
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100004
name: positive regulation of peroxisome organization by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that positively_regulates peroxisome organization" [GOC:cjm, GOC:obol]
is_a: GO:0006366 ! transcription from RNA polymerase II promoter
is_a: GO:1900064 ! positive regulation of peroxisome organization
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: positively_regulates GO:0007031 ! peroxisome organization
relationship: positively_regulates GO:0007031 ! peroxisome organization
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100005
name: positive regulation of ethanol catabolic process by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that positively_regulates ethanol catabolic process" [GOC:cjm, GOC:obol]
is_a: GO:0006366 ! transcription from RNA polymerase II promoter
is_a: GO:1900066 ! positive regulation of ethanol catabolic process
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: positively_regulates GO:0006068 ! ethanol catabolic process
relationship: positively_regulates GO:0006068 ! ethanol catabolic process
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100006
name: positive regulation of sulfite transport by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that positively_regulates sulfite transport" [GOC:cjm, GOC:obol]
is_a: GO:0100020 ! regulation of transport by transcription from RNA polymerase II promoter
is_a: GO:1900072 ! positive regulation of sulfite transport
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: positively_regulates GO:0000316 ! sulfite transport
relationship: positively_regulates GO:0000316 ! sulfite transport
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100007
name: negative regulation of ceramide biosynthetic process by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that negatively_regulates ceramide biosynthetic process" [GOC:cjm, GOC:obol]
is_a: GO:0006366 ! transcription from RNA polymerase II promoter
is_a: GO:1900060 ! negative regulation of ceramide biosynthetic process
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: negatively_regulates GO:0046513 ! ceramide biosynthetic process
relationship: negatively_regulates GO:0046513 ! ceramide biosynthetic process
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100008
name: regulation of fever generation by prostaglandin biosynthetic process
namespace: biological_process
def: "Any prostaglandin biosynthetic process process that regulates fever generation" [GOC:cjm, GOC:obol]
is_a: GO:0001516 ! prostaglandin biosynthetic process
is_a: GO:0031620 ! regulation of fever generation
intersection_of: GO:0001516 ! prostaglandin biosynthetic process
intersection_of: regulates GO:0001660 ! fever generation
relationship: regulates GO:0001660 ! fever generation
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100009
name: regulation of fever generation by prostaglandin secretion
namespace: biological_process
def: "Any prostaglandin secretion process that regulates fever generation" [GOC:cjm, GOC:obol]
is_a: GO:0031620 ! regulation of fever generation
is_a: GO:0032310 ! prostaglandin secretion
intersection_of: GO:0032310 ! prostaglandin secretion
intersection_of: regulates GO:0001660 ! fever generation
relationship: regulates GO:0001660 ! fever generation
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100010
name: positive regulation of fever generation by prostaglandin biosynthetic process
namespace: biological_process
def: "Any prostaglandin biosynthetic process process that positively_regulates fever generation" [GOC:cjm, GOC:obol]
is_a: GO:0031622 ! positive regulation of fever generation
is_a: GO:0100008 ! regulation of fever generation by prostaglandin biosynthetic process
intersection_of: GO:0001516 ! prostaglandin biosynthetic process
intersection_of: positively_regulates GO:0001660 ! fever generation
relationship: positively_regulates GO:0001660 ! fever generation
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100011
name: positive regulation of fever generation by prostaglandin secretion
namespace: biological_process
def: "Any prostaglandin secretion process that positively_regulates fever generation" [GOC:cjm, GOC:obol]
is_a: GO:0031622 ! positive regulation of fever generation
is_a: GO:0100009 ! regulation of fever generation by prostaglandin secretion
intersection_of: GO:0032310 ! prostaglandin secretion
intersection_of: positively_regulates GO:0001660 ! fever generation
relationship: positively_regulates GO:0001660 ! fever generation
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100012
name: regulation of heart induction by canonical Wnt signaling pathway
namespace: biological_process
def: "Any canonical Wnt signaling pathway process that regulates heart induction" [GOC:cjm, GOC:obol]
is_a: GO:0060070 ! canonical Wnt signaling pathway
is_a: GO:0090381 ! regulation of heart induction
intersection_of: GO:0060070 ! canonical Wnt signaling pathway
intersection_of: regulates GO:0003129 ! heart induction
relationship: regulates GO:0003129 ! heart induction
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100013
name: positive regulation of fatty acid beta-oxidation by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that positively_regulates fatty acid beta-oxidation" [GOC:cjm, GOC:obol]
is_a: GO:0006366 ! transcription from RNA polymerase II promoter
is_a: GO:0032000 ! positive regulation of fatty acid beta-oxidation
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: positively_regulates GO:0006635 ! fatty acid beta-oxidation
relationship: positively_regulates GO:0006635 ! fatty acid beta-oxidation
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100014
name: positive regulation of mating type switching by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that positively_regulates mating type switching" [GOC:cjm, GOC:obol]
is_a: GO:0006366 ! transcription from RNA polymerase II promoter
is_a: GO:0031496 ! positive regulation of mating type switching
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: positively_regulates GO:0007533 ! mating type switching
relationship: positively_regulates GO:0007533 ! mating type switching
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100015
name: positive regulation of inositol biosynthetic process by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that positively_regulates inositol biosynthetic process" [GOC:cjm, GOC:obol]
is_a: GO:0100024 ! regulation of carbohydrate metabolic process by transcription from RNA polymerase II promoter
is_a: GO:1900090 ! positive regulation of inositol biosynthetic process
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: positively_regulates GO:0006021 ! inositol biosynthetic process
relationship: positively_regulates GO:0006021 ! inositol biosynthetic process
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100016
name: regulation of thiamine biosynthetic process by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that regulates thiamine biosynthetic process" [GOC:cjm, GOC:obol]
is_a: GO:0006366 ! transcription from RNA polymerase II promoter
is_a: GO:0070623 ! regulation of thiamine biosynthetic process
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: regulates GO:0009228 ! thiamine biosynthetic process
relationship: regulates GO:0009228 ! thiamine biosynthetic process
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100017
name: negative regulation of cell-cell adhesion by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that negatively_regulates single organismal cell-cell adhesion" [GOC:cjm, GOC:obol]
is_a: GO:0006366 ! transcription from RNA polymerase II promoter
is_a: GO:0022408 ! negative regulation of cell-cell adhesion
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: negatively_regulates GO:0016337 ! single organismal cell-cell adhesion
relationship: negatively_regulates GO:0016337 ! single organismal cell-cell adhesion
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100018
name: regulation of glucose import by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that regulates glucose import" [GOC:cjm, GOC:obol]
is_a: GO:0046324 ! regulation of glucose import
is_a: GO:0100020 ! regulation of transport by transcription from RNA polymerase II promoter
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: regulates GO:0046323 ! glucose import
relationship: regulates GO:0046323 ! glucose import
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100019
name: regulation of cAMP-mediated signaling by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that regulates cAMP-mediated signaling" [GOC:cjm, GOC:obol]
is_a: GO:0006366 ! transcription from RNA polymerase II promoter
is_a: GO:0043949 ! regulation of cAMP-mediated signaling
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: regulates GO:0019933 ! cAMP-mediated signaling
relationship: regulates GO:0019933 ! cAMP-mediated signaling
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100020
name: regulation of transport by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that regulates transport" [GOC:cjm, GOC:obol]
is_a: GO:0006366 ! transcription from RNA polymerase II promoter
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: regulates GO:0006810 ! transport
relationship: regulates GO:0006810 ! transport
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100021
name: regulation of iron ion transport by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that regulates iron ion transport" [GOC:cjm, GOC:obol]
is_a: GO:0034756 ! regulation of iron ion transport
is_a: GO:0100020 ! regulation of transport by transcription from RNA polymerase II promoter
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: regulates GO:0006826 ! iron ion transport
relationship: regulates GO:0006826 ! iron ion transport
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100022
name: regulation of iron ion import by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that regulates iron ion import" [GOC:cjm, GOC:obol]
is_a: GO:0100021 ! regulation of iron ion transport by transcription from RNA polymerase II promoter
is_a: GO:1900390 ! regulation of iron ion import
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: regulates GO:0097286 ! iron ion import
relationship: regulates GO:0097286 ! iron ion import
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100023
name: regulation of meiotic nuclear division by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that regulates meiotic nuclear division" [GOC:cjm, GOC:obol]
is_a: GO:0006366 ! transcription from RNA polymerase II promoter
is_a: GO:0040020 ! regulation of meiotic nuclear division
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: regulates GO:0007126 ! meiotic nuclear division
relationship: regulates GO:0007126 ! meiotic nuclear division
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100024
name: regulation of carbohydrate metabolic process by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that regulates carbohydrate metabolic process" [GOC:cjm, GOC:obol]
is_a: GO:0006109 ! regulation of carbohydrate metabolic process
is_a: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: regulates GO:0005975 ! carbohydrate metabolic process
relationship: regulates GO:0005975 ! carbohydrate metabolic process
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100025
name: negative regulation of cellular amino acid biosynthetic process by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that negatively_regulates cellular amino acid biosynthetic process" [GOC:cjm, GOC:obol]
is_a: GO:0006366 ! transcription from RNA polymerase II promoter
is_a: GO:2000283 ! negative regulation of cellular amino acid biosynthetic process
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: negatively_regulates GO:0008652 ! cellular amino acid biosynthetic process
relationship: negatively_regulates GO:0008652 ! cellular amino acid biosynthetic process
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100026
name: positive regulation of DNA repair by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that positively_regulates DNA repair" [GOC:cjm, GOC:obol]
is_a: GO:0006366 ! transcription from RNA polymerase II promoter
is_a: GO:0045739 ! positive regulation of DNA repair
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: positively_regulates GO:0006281 ! DNA repair
relationship: positively_regulates GO:0006281 ! DNA repair
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100027
name: regulation of cell separation after cytokinesis by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that regulates cell separation after cytokinesis" [GOC:cjm, GOC:obol]
is_a: GO:0006366 ! transcription from RNA polymerase II promoter
is_a: GO:0010590 ! regulation of cell separation after cytokinesis
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: regulates GO:0000920 ! cell separation after cytokinesis
relationship: regulates GO:0000920 ! cell separation after cytokinesis
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100028
name: regulation of conjugation with cellular fusion by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that regulates conjugation with cellular fusion" [GOC:cjm, GOC:obol]
is_a: GO:0006366 ! transcription from RNA polymerase II promoter
is_a: GO:0031137 ! regulation of conjugation with cellular fusion
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: regulates GO:0000747 ! conjugation with cellular fusion
relationship: regulates GO:0000747 ! conjugation with cellular fusion
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100029
name: regulation of histone modification by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that regulates histone modification" [GOC:cjm, GOC:obol]
is_a: GO:0006366 ! transcription from RNA polymerase II promoter
is_a: GO:0031056 ! regulation of histone modification
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: regulates GO:0016570 ! histone modification
relationship: regulates GO:0016570 ! histone modification
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100030
name: regulation of histone acetylation by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that regulates histone acetylation" [GOC:cjm, GOC:obol]
is_a: GO:0035065 ! regulation of histone acetylation
is_a: GO:0100029 ! regulation of histone modification by transcription from RNA polymerase II promoter
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: regulates GO:0016573 ! histone acetylation
relationship: regulates GO:0016573 ! histone acetylation
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100031
name: regulation of histone methylation by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that regulates histone methylation" [GOC:cjm, GOC:obol]
is_a: GO:0031060 ! regulation of histone methylation
is_a: GO:0100029 ! regulation of histone modification by transcription from RNA polymerase II promoter
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: regulates GO:0016571 ! histone methylation
relationship: regulates GO:0016571 ! histone methylation
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100032
name: positive regulation of phospholipid biosynthetic process by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that positively_regulates phospholipid biosynthetic process" [GOC:cjm, GOC:obol]
is_a: GO:0006366 ! transcription from RNA polymerase II promoter
is_a: GO:0071073 ! positive regulation of phospholipid biosynthetic process
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: positively_regulates GO:0008654 ! phospholipid biosynthetic process
relationship: positively_regulates GO:0008654 ! phospholipid biosynthetic process
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100033
name: regulation of fungal-type cell wall biogenesis by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that regulates fungal-type cell wall biogenesis" [GOC:cjm, GOC:obol]
is_a: GO:0006366 ! transcription from RNA polymerase II promoter
is_a: GO:0032995 ! regulation of fungal-type cell wall biogenesis
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: regulates GO:0009272 ! fungal-type cell wall biogenesis
relationship: regulates GO:0009272 ! fungal-type cell wall biogenesis
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100034
name: regulation of 4,6-pyruvylated galactose residue biosynthetic process by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that regulates 4,6-pyruvylated galactose residue biosynthetic process" [GOC:cjm, GOC:obol]
is_a: GO:0060634 ! regulation of 4,6-pyruvylated galactose residue biosynthetic process
is_a: GO:0100024 ! regulation of carbohydrate metabolic process by transcription from RNA polymerase II promoter
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: regulates GO:0051072 ! 4,6-pyruvylated galactose residue biosynthetic process
relationship: regulates GO:0051072 ! 4,6-pyruvylated galactose residue biosynthetic process
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100035
name: negative regulation of transmembrane transport by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that negatively_regulates transmembrane transport" [GOC:cjm, GOC:obol]
is_a: GO:0034763 ! negative regulation of transmembrane transport
is_a: GO:0100020 ! regulation of transport by transcription from RNA polymerase II promoter
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: negatively_regulates GO:0055085 ! transmembrane transport
relationship: negatively_regulates GO:0055085 ! transmembrane transport
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100036
name: positive regulation of purine nucleotide biosynthetic process by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that positively_regulates purine nucleotide biosynthetic process" [GOC:cjm, GOC:obol]
is_a: GO:0006366 ! transcription from RNA polymerase II promoter
is_a: GO:1900373 ! positive regulation of purine nucleotide biosynthetic process
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: positively_regulates GO:0006164 ! purine nucleotide biosynthetic process
relationship: positively_regulates GO:0006164 ! purine nucleotide biosynthetic process
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100037
name: positive regulation of cellular alcohol catabolic process by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that positively_regulates cellular alcohol catabolic process" [GOC:cjm, GOC:obol]
is_a: GO:0006366 ! transcription from RNA polymerase II promoter
is_a: GO:1900421 ! positive regulation of cellular alcohol catabolic process
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: positively_regulates GO:0044109 ! cellular alcohol catabolic process
relationship: positively_regulates GO:0044109 ! cellular alcohol catabolic process
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100038
name: regulation of cellular response to oxidative stress by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that regulates cellular response to oxidative stress" [GOC:cjm, GOC:obol]
is_a: GO:0006366 ! transcription from RNA polymerase II promoter
is_a: GO:1900407 ! regulation of cellular response to oxidative stress
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: regulates GO:0034599 ! cellular response to oxidative stress
relationship: regulates GO:0034599 ! cellular response to oxidative stress
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100039
name: regulation of pyrimidine nucleotide biosynthetic process by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that regulates pyrimidine nucleotide biosynthetic process" [GOC:cjm, GOC:obol]
is_a: GO:0006366 ! transcription from RNA polymerase II promoter
is_a: GO:1900397 ! regulation of pyrimidine nucleotide biosynthetic process
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: regulates GO:0006221 ! pyrimidine nucleotide biosynthetic process
relationship: regulates GO:0006221 ! pyrimidine nucleotide biosynthetic process
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100040
name: negative regulation of invasive growth in response to glucose limitation by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that negatively_regulates invasive growth in response to glucose limitation" [GOC:cjm, GOC:obol]
is_a: GO:0006366 ! transcription from RNA polymerase II promoter
is_a: GO:2000218 ! negative regulation of invasive growth in response to glucose limitation
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: negatively_regulates GO:0001403 ! invasive growth in response to glucose limitation
relationship: negatively_regulates GO:0001403 ! invasive growth in response to glucose limitation
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100041
name: positive regulation of pseudohyphal growth by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that positively_regulates pseudohyphal growth" [GOC:cjm, GOC:obol]
is_a: GO:0006366 ! transcription from RNA polymerase II promoter
is_a: GO:2000222 ! positive regulation of pseudohyphal growth
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: positively_regulates GO:0007124 ! pseudohyphal growth
relationship: positively_regulates GO:0007124 ! pseudohyphal growth
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100042
name: negative regulation of pseudohyphal growth by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that negatively_regulates pseudohyphal growth" [GOC:cjm, GOC:obol]
is_a: GO:0006366 ! transcription from RNA polymerase II promoter
is_a: GO:2000221 ! negative regulation of pseudohyphal growth
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: negatively_regulates GO:0007124 ! pseudohyphal growth
relationship: negatively_regulates GO:0007124 ! pseudohyphal growth
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100043
name: negative regulation of cellular response to alkaline pH by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that negatively_regulates cellular response to alkaline pH" [GOC:cjm, GOC:obol]
is_a: GO:0006366 ! transcription from RNA polymerase II promoter
is_a: GO:1900068 ! negative regulation of cellular response to alkaline pH
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: negatively_regulates GO:0071469 ! cellular response to alkaline pH
relationship: negatively_regulates GO:0071469 ! cellular response to alkaline pH
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100044
name: negative regulation of cellular hyperosmotic salinity response by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that negatively_regulates cellular hyperosmotic salinity response" [GOC:cjm, GOC:obol]
is_a: GO:0006366 ! transcription from RNA polymerase II promoter
is_a: GO:1900070 ! negative regulation of cellular hyperosmotic salinity response
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: negatively_regulates GO:0071475 ! cellular hyperosmotic salinity response
relationship: negatively_regulates GO:0071475 ! cellular hyperosmotic salinity response
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100045
name: negative regulation of arginine catabolic process by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that negatively_regulates arginine catabolic process" [GOC:cjm, GOC:obol]
is_a: GO:0006366 ! transcription from RNA polymerase II promoter
is_a: GO:1900082 ! negative regulation of arginine catabolic process
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: negatively_regulates GO:0006527 ! arginine catabolic process
relationship: negatively_regulates GO:0006527 ! arginine catabolic process
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100046
name: positive regulation of arginine biosynthetic process by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that positively_regulates arginine biosynthetic process" [GOC:cjm, GOC:obol]
is_a: GO:0006366 ! transcription from RNA polymerase II promoter
is_a: GO:1900080 ! positive regulation of arginine biosynthetic process
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: positively_regulates GO:0006526 ! arginine biosynthetic process
relationship: positively_regulates GO:0006526 ! arginine biosynthetic process
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100047
name: negative regulation of inositol biosynthetic process by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that negatively_regulates inositol biosynthetic process" [GOC:cjm, GOC:obol]
is_a: GO:0100024 ! regulation of carbohydrate metabolic process by transcription from RNA polymerase II promoter
is_a: GO:1900089 ! negative regulation of inositol biosynthetic process
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: negatively_regulates GO:0006021 ! inositol biosynthetic process
relationship: negatively_regulates GO:0006021 ! inositol biosynthetic process
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100048
name: positive regulation of phosphatidylcholine biosynthetic process by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that positively_regulates phosphatidylcholine biosynthetic process" [GOC:cjm, GOC:obol]
is_a: GO:0100032 ! positive regulation of phospholipid biosynthetic process by transcription from RNA polymerase II promoter
is_a: GO:2001247 ! positive regulation of phosphatidylcholine biosynthetic process
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: positively_regulates GO:0006656 ! phosphatidylcholine biosynthetic process
relationship: positively_regulates GO:0006656 ! phosphatidylcholine biosynthetic process
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100049
name: negative regulation of phosphatidylcholine biosynthetic process by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that negatively_regulates phosphatidylcholine biosynthetic process" [GOC:cjm, GOC:obol]
is_a: GO:0006366 ! transcription from RNA polymerase II promoter
is_a: GO:2001246 ! negative regulation of phosphatidylcholine biosynthetic process
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: negatively_regulates GO:0006656 ! phosphatidylcholine biosynthetic process
relationship: negatively_regulates GO:0006656 ! phosphatidylcholine biosynthetic process
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100050
name: negative regulation of mating type switching by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that negatively_regulates mating type switching" [GOC:cjm, GOC:obol]
is_a: GO:0006366 ! transcription from RNA polymerase II promoter
is_a: GO:0031495 ! negative regulation of mating type switching
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: negatively_regulates GO:0007533 ! mating type switching
relationship: negatively_regulates GO:0007533 ! mating type switching
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100051
name: positive regulation of meiotic nuclear division by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that positively_regulates meiotic nuclear division" [GOC:cjm, GOC:obol]
is_a: GO:0045836 ! positive regulation of meiotic nuclear division
is_a: GO:0100023 ! regulation of meiotic nuclear division by transcription from RNA polymerase II promoter
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: positively_regulates GO:0007126 ! meiotic nuclear division
relationship: positively_regulates GO:0007126 ! meiotic nuclear division
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100052
name: negative regulation of G1/S transition of mitotic cell cycle by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that negatively_regulates G1/S transition of mitotic cell cycle" [GOC:cjm, GOC:obol]
is_a: GO:0006366 ! transcription from RNA polymerase II promoter
is_a: GO:2000134 ! negative regulation of G1/S transition of mitotic cell cycle
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: negatively_regulates GO:0000082 ! G1/S transition of mitotic cell cycle
relationship: negatively_regulates GO:0000082 ! G1/S transition of mitotic cell cycle
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100053
name: positive regulation of sulfate assimilation by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that positively_regulates sulfate assimilation" [GOC:cjm, GOC:obol]
is_a: GO:0006366 ! transcription from RNA polymerase II promoter
is_a: GO:1900059 ! positive regulation of sulfate assimilation
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: positively_regulates GO:0000103 ! sulfate assimilation
relationship: positively_regulates GO:0000103 ! sulfate assimilation
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100054
name: positive regulation of flocculation via cell wall protein-carbohydrate interaction by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that positively_regulates flocculation via cell wall protein-carbohydrate interaction" [GOC:cjm, GOC:obol]
is_a: GO:0006366 ! transcription from RNA polymerase II promoter
is_a: GO:1900479 ! positive regulation of flocculation via cell wall protein-carbohydrate interaction
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: positively_regulates GO:0000501 ! flocculation via cell wall protein-carbohydrate interaction
relationship: positively_regulates GO:0000501 ! flocculation via cell wall protein-carbohydrate interaction
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100055
name: positive regulation of phosphatidylserine biosynthetic process by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that positively_regulates phosphatidylserine biosynthetic process" [GOC:cjm, GOC:obol]
is_a: GO:0100032 ! positive regulation of phospholipid biosynthetic process by transcription from RNA polymerase II promoter
is_a: GO:1900470 ! positive regulation of phosphatidylserine biosynthetic process
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: positively_regulates GO:0006659 ! phosphatidylserine biosynthetic process
relationship: positively_regulates GO:0006659 ! phosphatidylserine biosynthetic process
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100056
name: negative regulation of phosphatidylserine biosynthetic process by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that negatively_regulates phosphatidylserine biosynthetic process" [GOC:cjm, GOC:obol]
is_a: GO:0100025 ! negative regulation of cellular amino acid biosynthetic process by transcription from RNA polymerase II promoter
is_a: GO:1900469 ! negative regulation of phosphatidylserine biosynthetic process
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: negatively_regulates GO:0006659 ! phosphatidylserine biosynthetic process
relationship: negatively_regulates GO:0006659 ! phosphatidylserine biosynthetic process
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100057
name: regulation of phenotypic switching by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that regulates phenotypic switching" [GOC:cjm, GOC:obol]
is_a: GO:0006366 ! transcription from RNA polymerase II promoter
is_a: GO:1900239 ! regulation of phenotypic switching
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: regulates GO:0036166 ! phenotypic switching
relationship: regulates GO:0036166 ! phenotypic switching
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100058
name: positive regulation of phenotypic switching by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that positively_regulates phenotypic switching" [GOC:cjm, GOC:obol]
is_a: GO:0100057 ! regulation of phenotypic switching by transcription from RNA polymerase II promoter
is_a: GO:1900241 ! positive regulation of phenotypic switching
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: positively_regulates GO:0036166 ! phenotypic switching
relationship: positively_regulates GO:0036166 ! phenotypic switching
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100059
name: negative regulation of phenotypic switching by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that negatively_regulates phenotypic switching" [GOC:cjm, GOC:obol]
is_a: GO:0100057 ! regulation of phenotypic switching by transcription from RNA polymerase II promoter
is_a: GO:1900240 ! negative regulation of phenotypic switching
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: negatively_regulates GO:0036166 ! phenotypic switching
relationship: negatively_regulates GO:0036166 ! phenotypic switching
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100060
name: negative regulation of SREBP signaling pathway by DNA binding
namespace: molecular_function
def: "Any DNA binding that negatively_regulates SREBP signaling pathway" [GOC:cjm, GOC:obol]
is_a: GO:0003677 ! DNA binding
intersection_of: GO:0003677 ! DNA binding
intersection_of: negatively_regulates GO:0032933 ! SREBP signaling pathway
relationship: negatively_regulates GO:0032933 ! SREBP signaling pathway
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100061
name: negative regulation of SREBP signaling pathway by transcription factor catabolic process
namespace: biological_process
def: "Any transcription factor catabolic process process that negatively_regulates SREBP signaling pathway" [GOC:cjm, GOC:obol]
is_a: GO:0036369 ! transcription factor catabolic process
is_a: GO:2000639 ! negative regulation of SREBP signaling pathway
intersection_of: GO:0036369 ! transcription factor catabolic process
intersection_of: negatively_regulates GO:0032933 ! SREBP signaling pathway
relationship: negatively_regulates GO:0032933 ! SREBP signaling pathway
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100062
name: positive regulation of SREBP signaling pathway by transcription factor catabolic process
namespace: biological_process
def: "Any transcription factor catabolic process process that positively_regulates SREBP signaling pathway" [GOC:cjm, GOC:obol]
is_a: GO:0036369 ! transcription factor catabolic process
is_a: GO:2000640 ! positive regulation of SREBP signaling pathway
intersection_of: GO:0036369 ! transcription factor catabolic process
intersection_of: positively_regulates GO:0032933 ! SREBP signaling pathway
relationship: positively_regulates GO:0032933 ! SREBP signaling pathway
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100063
name: regulation of dipeptide transmembrane transport by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that regulates dipeptide transmembrane transport" [GOC:cjm, GOC:obol]
is_a: GO:0100020 ! regulation of transport by transcription from RNA polymerase II promoter
is_a: GO:2001148 ! regulation of dipeptide transmembrane transport
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: regulates GO:0035442 ! dipeptide transmembrane transport
relationship: regulates GO:0035442 ! dipeptide transmembrane transport
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100064
name: negative regulation of filamentous growth of a population of unicellular organisms in response to starvation by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that negatively_regulates filamentous growth of a population of unicellular organisms in response to starvation" [GOC:cjm, GOC:obol]
is_a: GO:0006366 ! transcription from RNA polymerase II promoter
is_a: GO:1900435 ! negative regulation of filamentous growth of a population of unicellular organisms in response to starvation
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: negatively_regulates GO:0036170 ! filamentous growth of a population of unicellular organisms in response to starvation
relationship: negatively_regulates GO:0036170 ! filamentous growth of a population of unicellular organisms in response to starvation
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100065
name: negative regulation of leucine import by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that negatively_regulates leucine import" [GOC:cjm, GOC:obol]
is_a: GO:0060358 ! negative regulation of leucine import
is_a: GO:0100020 ! regulation of transport by transcription from RNA polymerase II promoter
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: negatively_regulates GO:0060356 ! leucine import
relationship: negatively_regulates GO:0060356 ! leucine import
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100066
name: negative regulation of induction of conjugation with cellular fusion by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that negatively_regulates induction of conjugation with cellular fusion" [GOC:cjm, GOC:obol]
is_a: GO:0010515 ! negative regulation of induction of conjugation with cellular fusion
is_a: GO:0100028 ! regulation of conjugation with cellular fusion by transcription from RNA polymerase II promoter
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: negatively_regulates GO:0010514 ! induction of conjugation with cellular fusion
relationship: negatively_regulates GO:0010514 ! induction of conjugation with cellular fusion
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100067
name: positive regulation of spinal cord association neuron differentiation by canonical Wnt signaling pathway
namespace: biological_process
def: "Any canonical Wnt signaling pathway process that positively_regulates spinal cord association neuron differentiation" [GOC:cjm, GOC:obol]
is_a: GO:0060070 ! canonical Wnt signaling pathway
is_a: GO:1902831 ! positive regulation of spinal cord association neuron differentiation
intersection_of: GO:0060070 ! canonical Wnt signaling pathway
intersection_of: positively_regulates GO:0021527 ! spinal cord association neuron differentiation
relationship: positively_regulates GO:0021527 ! spinal cord association neuron differentiation
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100068
name: positive regulation of pyrimidine-containing compound salvage by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that positively_regulates pyrimidine-containing compound salvage" [GOC:cjm, GOC:obol]
is_a: GO:0006366 ! transcription from RNA polymerase II promoter
is_a: GO:1903931 ! positive regulation of pyrimidine-containing compound salvage
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: positively_regulates GO:0008655 ! pyrimidine-containing compound salvage
relationship: positively_regulates GO:0008655 ! pyrimidine-containing compound salvage
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100069
name: negative regulation of neuron apoptotic process by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that negatively_regulates neuron apoptotic process" [GOC:cjm, GOC:obol]
is_a: GO:0006366 ! transcription from RNA polymerase II promoter
is_a: GO:0043524 ! negative regulation of neuron apoptotic process
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: negatively_regulates GO:0051402 ! neuron apoptotic process
relationship: negatively_regulates GO:0051402 ! neuron apoptotic process
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0100070
name: regulation of fatty acid biosynthetic process by transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any transcription from RNA polymerase II promoter process that regulates fatty acid biosynthetic process" [GOC:cjm, GOC:obol]
is_a: GO:0006366 ! transcription from RNA polymerase II promoter
is_a: GO:0042304 ! regulation of fatty acid biosynthetic process
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: regulates GO:0006633 ! fatty acid biosynthetic process
relationship: regulates GO:0006633 ! fatty acid biosynthetic process
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0101002
name: ficolin-1-rich granule
namespace: cellular_component
def: "Highly exocytosable gelatinase-poor granules found in neutrophils and rich in ficolin-1.  Ficolin-1 is released from neutrophil granules by stimulation with fMLP or PMA, and the majority becomes associated with the surface membrane of the cells and can be detected by flow cytometry." [GOC:mec, PMID:19741154]
synonym: "ficolin granule" RELATED []
synonym: "ficolin-1 rich granule" EXACT []
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0101003
name: ficolin-1-rich granule membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a ficolin-1-rich granule." [GOC:mec, PMID:23650620]
is_a: GO:0030667 ! secretory granule membrane
relationship: part_of GO:0070820 ! tertiary granule
created_by: melanie

[Term]
id: GO:0101004
name: cytolytic granule membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the cytolytic granule." [PMID:17272266, PMID:21247065]
is_a: GO:0005765 ! lysosomal membrane
created_by: mec
creation_date: 2015-12-15T04:32:00Z

[Term]
id: GO:0101005
name: ubiquitinyl hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of ubiquitin from proteins and other molecules." [GOC:mec]
comment: There are two main classes of deubiquitinating enzymes: cysteine proteases (i.e., thiol dependent) and metalloproteases.
synonym: "deubiquitinase activity" EXACT []
synonym: "deubiquitinating peptidase activity" EXACT []
synonym: "ubiquitin hydrolase activity" EXACT []
is_a: GO:0016787 ! hydrolase activity
created_by: mec
creation_date: 2016-02-08T09:39:38Z

[Term]
id: GO:0101006
name: protein histidine phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein histidine phosphate + H2O = protein histidine + phosphate" [GOC:mec]
comment: Note that this term applies only to phosphoproteins. For free amino acids consider 'phosphohistidine phosphatase activity'. See discussion at https://github.com/geneontology/go-ontology/issues/12183
subset: gosubset_prok
is_a: GO:0004721 ! phosphoprotein phosphatase activity

[Term]
id: GO:0101007
name: negative regulation of transcription from RNA polymerase II promoter in response to salt stress
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under salt stress. The stress is usually an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:mec]
is_a: GO:0061416 ! regulation of transcription from RNA polymerase II promoter in response to salt stress
created_by: GOC:mec

[Term]
id: GO:0101008
name: negative regulation of transcription from RNA polymerase II promoter in response to increased salt
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:mec]
is_a: GO:0101007 ! negative regulation of transcription from RNA polymerase II promoter in response to salt stress
created_by: mec

[Term]
id: GO:0101010
name: pulmonary blood vessel remodeling
namespace: biological_process
def: "The reorganization or renovation of existing pulmonary blood vessels." [GOC:mec]
is_a: GO:0001974 ! blood vessel remodeling

[Term]
id: GO:0101011
name: inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate 1-diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate + H2O = myo-inositol hexakisphosphate + phosphate." [GOC:mah, PMID:26422458]
synonym: "inositol 1-pyrophosphate 2,3,4,5,6-pentakisphosphate 1-pyrophosphatase activity" EXACT []
is_a: GO:0052745 ! inositol phosphate phosphatase activity

[Term]
id: GO:0101012
name: inositol 1,5-bisdiphosphate 2,3,4,6-tetrakisphosphate 1-diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: myo-inositol 1,5-bisdiphosphate 2,3,4,6-tetrakisphosphate + H2O = myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate + phosphate." [GOC:mah, PMID:26422458]
synonym: "inositol 1,5-bispyrophosphate 2,3,4,6-tetrakisphosphate 1-pyrophosphatase activity" EXACT []
is_a: GO:0052745 ! inositol phosphate phosphatase activity

[Term]
id: GO:0101013
name: mechanically-modulated voltage-gated sodium channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel whose activity is modulated in response to mechanical stress. Response to mechanical stress and voltage gating  together is different than the sum of individual responses. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [PMID:21041530, PMID:26838316]
is_a: GO:0005248 ! voltage-gated sodium channel activity
is_a: GO:0008381 ! mechanically-gated ion channel activity

[Term]
id: GO:0101014
name: [isocitrate dehydrogenase (NADP+)] phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: [isocitrate dehydrogenase] phosphate + H2O = [isocitrate dehydrogenase] + phosphate." [EC:2.7.11.5]
synonym: "isocitrate dehydrogenase kinase/phosphatase activity" EXACT [EC:2.7.11.5]
xref: EC:2.7.11.5
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0101016
name: FMN-binding domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the FMN-binding domain of a protein." [PMID:15752726]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0102001
name: isoleucine N-monooxygenase (oxime forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: L-isoleucine + 2 O2 + 2 NADPH(4-) + 2 H+ <=> (E)-2-methylbutanal oxime + 2 NADP(3-) + carbon dioxide + 3 H2O." [EC:1.14.13.117]
xref: EC:1.14.13.117
xref: MetaCyc:1.14.13.117-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102002
name: valine N-monooxygenase (oxime forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: L-valine + 2 O2 + 2 NADPH(4-) + 2 H+ <=> (E)-2-methylpropanal oxime + 2 NADP(3-) + carbon dioxide + 3 H2O." [EC:1.14.13.118]
xref: EC:1.14.13.118
xref: MetaCyc:1.14.13.118-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102003
name: Delta8-sphingolipid desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: phytosphingosine(1+) + O2 + a reduced electron acceptor <=> 4-hydroxy-trans-8-sphingenine + 2 H2O + an oxidized electron acceptor." [EC:1.14.19.4]
xref: EC:1.14.19.4
xref: MetaCyc:1.14.19.4-RXN
is_a: GO:0052631 ! sphingolipid delta-8 desaturase activity

[Term]
id: GO:0102004
name: 2-octaprenyl-6-hydroxyphenol methylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-(all-trans-octaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine <=> H+ + 2-methoxy-6-(all-trans-octaprenyl)phenol + S-adenosyl-L-homocysteine." [EC:2.1.1.222]
xref: EC:2.1.1.222
xref: MetaCyc:2-OCTAPRENYL-6-OHPHENOL-METHY-RXN
is_a: GO:1990888 ! 2-polyprenyl-6-hydroxyphenol O-methyltransferase activity

[Term]
id: GO:0102005
name: 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-methoxy-2-octaprenylhydroquinone + S-adenosyl-L-methionine <=> H+ + S-adenosyl-L-homocysteine + 5-methoxy-2-methyl-3-octaprenylhydroquinone." [EC:2.1.1.201]
xref: EC:2.1.1.201
xref: MetaCyc:2-OCTAPRENYL-METHOXY-BENZOQ-METH-RXN
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102006
name: 4-methyl-2-oxopentanoate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-methyl-2-oxopentanoate + coenzyme A(4-) + NAD(1-) <=> isovaleryl-CoA(4-) + carbon dioxide + NADH(2-)." [EC:1.2.1.-]
xref: MetaCyc:2KETO-4METHYL-PENTANOATE-DEHYDROG-RXN
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0102007
name: acyl-L-homoserine-lactone lactonohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + an N-acyl-L-homoserine lactone <=> H+ + an N-acyl-L-homoserine." [EC:3.1.1.81]
xref: EC:3.1.1.81
xref: MetaCyc:3.1.1.81-RXN
is_a: GO:0046573 ! lactonohydrolase activity

[Term]
id: GO:0102008
name: cytosolic dipeptidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + a dipeptide <=> 2 a standard alpha amino acid that occurs in the cytosol" [EC:3.4.13.18]
xref: EC:3.4.13.18
xref: MetaCyc:3.4.13.18-RXN
is_a: GO:0016805 ! dipeptidase activity

[Term]
id: GO:0102009
name: proline dipeptidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + a dipeptide with proline at the C-terminal <=> L-proline + a standard alpha amino acid." [EC:3.4.13.9]
xref: EC:3.4.13.9
xref: MetaCyc:3.4.13.9-RXN
is_a: GO:0016805 ! dipeptidase activity

[Term]
id: GO:0102013
name: L-glutamate-importing ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP(4-) + L-glutamate(1-) + H2O <=> ADP(3-) + hydrogenphosphate + L-glutamate(1-) + H+." [EC:3.6.3.21]
xref: MetaCyc:ABC-13-RXN
is_a: GO:0015426 ! polar-amino acid-transporting ATPase activity
is_a: GO:0032520 ! amino acid-importing ATPase activity

[Term]
id: GO:0102014
name: beta-D-galactose-importing ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP(4-) + beta-D-galactoside + H2O <=> ADP(3-) + hydrogenphosphate + beta-D-galactoside + H+." [EC:3.6.3.17]
xref: MetaCyc:ABC-18-RXN
is_a: GO:0015407 ! monosaccharide-transporting ATPase activity

[Term]
id: GO:0102017
name: alkylphosphonate transmembrane-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP(4-) + H2O + an alkylphosphonate <=> ADP(3-) + hydrogenphosphate + H+ + an alkylphosphonate." [EC:3.6.3.28]
synonym: "alkylphosphonate ABC transporter activity" EXACT []
xref: MetaCyc:ABC-23-RXN
is_a: GO:0015416 ! organic phosphonate transmembrane-transporting ATPase activity

[Term]
id: GO:0102022
name: L-arginine-importing ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP(4-) + L-argininium(1+) + H2O <=> ADP(3-) + hydrogenphosphate + L-argininium(1+) + H+." [EC:3.6.3.21]
xref: MetaCyc:ABC-4-RXN
is_a: GO:0015598 ! arginine-importing ATPase activity
is_a: GO:0061459 ! L-arginine transmembrane transporter activity

[Term]
id: GO:0102027
name: S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-demethylmenaquinol-8 + S-adenosyl-L-methionine <=> menaquinol-8 + H+ + S-adenosyl-L-homocysteine." [EC:2.1.1.163]
xref: MetaCyc:ADOMET-DMK-METHYLTRANSFER-RXN
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102030
name: dTDP-L-rhamnose synthetase activity
namespace: molecular_function
def: "Catalysis of the reaction: dTDP-6-deoxy-beta-L-mannose + NAD+ <=> dTDP-4-dehydro-6-deoxy-alpha-D-glucose + NADH + H+" [EC:1.1.1.-, MetaCyc:DTDPRHAMSYNTHMULTI-RXN]
xref: MetaCyc:DTDPRHAMSYNTHMULTI-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0102031
name: 4-acetamido-4,6-dideoxy-D-galactose transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-1-diphospho-ditrans,polycis-undecaprenol <=> H+ + alpha-D-FucNAc4-(1->4)-beta-D-ManNAcA-(1->4)-D-GlcNAc-undecaprenyl diphosphate + dTDP" [EC:2.4.1.325]
xref: EC:2.4.1.325
xref: MetaCyc:FUC4NACTRANS-RXN
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0102033
name: cytochrome P450 fatty acid omega-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: linoleoyl-CoA(4-) + H2O <=> H+ + linoleate + coenzyme A" [EC:3.1.2.-, MetaCyc:LINOLEOYL-RXN]
xref: MetaCyc:LINOLEOYL-RXN
is_a: GO:0016790 ! thiolester hydrolase activity

[Term]
id: GO:0102035
name: isobutyryl-CoA:FAD oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + isobutyryl-CoA + FAD <=> methacrylyl-CoA + FADH2" [EC:1.3.8.-, MetaCyc:MEPROPCOA-FAD-RXN]
xref: MetaCyc:MEPROPCOA-FAD-RXN
is_a: GO:0052890 ! oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor

[Term]
id: GO:0102036
name: methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a tetrahydrofolate + a [methyl-Co(III) corrinoid Fe-S protein] <=> an N5-methyl-tetrahydrofolate + a [Co(I) corrinoid Fe-S protein]" [EC:2.1.1.258]
xref: EC:2.1.1.258
xref: MetaCyc:METHCOCLTH-RXN
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102037
name: 4-nitrotoluene monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + 4-nitrotoluene + NADH + O2 <=> 4-nitrobenzyl alcohol + NAD+ + H2O" [EC:1.14.13.-, MetaCyc:R361-RXN]
xref: MetaCyc:R361-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102044
name: 3-chlorobenzoate-4,5-oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-chlorobenzoate + O2 + a reduced electron acceptor <=> 3-chlorobenzoate-cis-4,5-diol + an oxidized electron acceptor" [EC:1.14.12.-]
xref: MetaCyc:RXN-10421
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0102045
name: 3-chlorobenzoate-3,4-oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-chlorobenzoate + O2 + a reduced electron acceptor <=> 3-chlorobenzoate-cis-3,4-diol + an oxidized electron acceptor" [EC:1.14.12.-]
xref: MetaCyc:RXN-10422
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0102046
name: 3,4-dichlorobenzoate-4,5-oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,4-dichlorobenzoate + O2 + a reduced electron acceptor <=> 3,4-dichlorobenzoate-cis-4,5-diol + an oxidized electron acceptor" [EC:1.14.12.-]
xref: MetaCyc:RXN-10427
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0102117
name: gibberellin A9 carboxyl methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: gibberellin A9 + S-adenosyl-L-methionine  <=> gibberellin A9 methyl ester + S-adenosyl-L-homocysteine " [EC:2.1.1.275]
xref: EC:2.1.1.275
xref: MetaCyc:RXN-11358
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102118
name: gibberellin A4 carboxyl methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: gibberellin A4 + S-adenosyl-L-methionine  <=> gibberellin A4 methyl ester + S-adenosyl-L-homocysteine " [EC:2.1.1.276]
xref: EC:2.1.1.276
xref: MetaCyc:RXN-11359
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102119
name: gibberellin A20 carboxyl methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: gibberellin A20 + S-adenosyl-L-methionine  <=> gibberellin A20 methyl ester + S-adenosyl-L-homocysteine " [EC:2.1.1.-]
xref: MetaCyc:RXN-11360
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102138
name: 7-oxatyphasterol synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + typhasterol + NADPH + O2 <=> 7-oxatyphasterol + NADP + H2O" [EC:1.14.13.-]
xref: MetaCyc:RXN-11538
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102159
name: baicalein 7-O-glucuronosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-alpha-D-glucuronate + baicalein <=> H+ + UDP + baicalin" [EC:2.4.1.253]
xref: EC:2.4.1.253
xref: MetaCyc:RXN-11755
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0102160
name: cyanidin-3-O-glucoside 2-O-glucuronosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + UDP-alpha-D-glucuronate <=> H+ + cyanidin 3-O-beta-(2-O-beta-D-glucuronosyl)-beta-D-glucoside + UDP" [EC:2.4.1.254]
xref: EC:2.4.1.254
xref: MetaCyc:RXN-11756
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0102161
name: copal-8-ol diphosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: copal-8-ol diphosphate <=> 2-trans,6-trans,10-trans-geranylgeranyl diphosphate + H2O" [EC:4.2.1.133]
xref: EC:4.2.1.133
xref: MetaCyc:RXN-11772
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0102169
name: pyocyanin hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-methylphenazine-1-carboxylate + NADH + O2 + 2 H+ <=> pyocyanin + NAD + carbon dioxide + H2O" [EC:1.14.13.-]
xref: MetaCyc:RXN-11898
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102176
name: cycloeucalenone reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: cycloeucalenone + NADPH + H+ <=> cycloeucalenol + NADP" [EC:1.1.1.-]
xref: MetaCyc:RXN-11929
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0102209
name: trans-permethrin hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (-)-trans-permethrin + H2O <=> H+ + (3-phenoxyphenyl)methanol + (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate" [EC:3.1.1.88]
xref: EC:3.1.1.88
xref: MetaCyc:RXN-12167
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0102210
name: rhamnogalacturonan endolyase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + a rhamnogalacturonan type I <=> [rhamnogalacturonan I oligosaccharide]-alpha-L-rhamnose + 4-deoxy-4,5-unsaturated D-galactopyranosyluronate-[rhamnogalacturonan I oligosaccharide]" [EC:4.2.2.23]
xref: EC:4.2.2.23
xref: MetaCyc:RXN-12173
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0102211
name: unsaturated rhamnogalacturonyl hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-O-(4-deoxy-beta-L-threo-hex-4-enopyranuronosyl)-alpha-L-rhamnopyranose(1-) + H2O <=> (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + alpha-L-rhamnopyranose" [EC:3.2.1.172]
xref: EC:3.2.1.172
xref: MetaCyc:RXN-12174
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0102240
name: soyasapogenol B glucuronide galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-D-galactose + soyasapogenol B 3-O-beta-glucuronate <=> H+ + UDP + soyasaponin III" [EC:2.4.1.272]
xref: EC:2.4.1.272
xref: MetaCyc:RXN-12319
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0102241
name: soyasaponin III rhamnosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-L-rhamnose + soyasaponin III <=> H+ + UDP + soyasaponin I" [EC:2.4.1.273]
xref: EC:2.4.1.273
xref: MetaCyc:RXN-12320
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0102251
name: all-trans-beta-apo-10'-carotenal cleavage oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 10'-apo-beta-carotenal + O2 <=> 13-apo-beta-carotenone + 4-methylocta-2,4,6-trienedial" [EC:1.13.11.70]
xref: EC:1.13.11.70
xref: MetaCyc:RXN-12393
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0102260
name: germacrene A alcohol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: germacra-1(10),4,11(13)-trien-12-ol + 2 NADP + H2O <=> germacra-1(10),4,11(13)-trien-12-oate + 2 NADPH + 3 H+" [EC:1.1.1.314]
xref: EC:1.1.1.314
xref: MetaCyc:RXN-12449
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0102279
name: lecithin:11-cis retinol acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: an 11-cis retinol-[cellular-retinol-binding-protein] + a phosphatidylcholine <=> a cellular-retinol-binding protein + an 11-cis-retinyl ester + a 1-lysophosphatidylcholine" [EC:2.3.1.135]
xref: EC:2.3.1.135
xref: MetaCyc:RXN-12563
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0102299
name: linolenate 9R-lipoxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-linolenate + O2 <=> (9R,10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate" [EC:1.13.11.61]
xref: EC:1.13.11.61
xref: MetaCyc:RXN-12759
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0102312
name: 4-coumaroyl 2'-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-coumaryl-CoA + 2-oxoglutarate + O2 <=> 2,4-dihydroxycinnamoyl-CoA + succinate + carbon dioxide" [EC:1.14.11.-]
xref: MetaCyc:RXN-12963
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0102313
name: 1,8-cineole synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranyl diphosphate(3-) + H2O <=> 1,8-cineole + diphosphoric acid" [EC:4.2.3.108]
xref: EC:4.2.3.108
xref: MetaCyc:RXN-12980
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0102383
name: steviol glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: steviol + UDP-alpha-D-glucose <=> 19-O-beta-glucopyranosyl-steviol + UDP + H+" [EC:2.4.1.-]
xref: MetaCyc:RXN-13520
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0102384
name: 19-O-beta-glucopyranosyl-steviol glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 19-O-beta-glucopyranosyl-steviol + UDP-alpha-D-glucose <=> rubusoside + UDP + H+" [EC:2.4.1.-]
xref: MetaCyc:RXN-13521
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0102385
name: patchoulol synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) <=> seychellene + diphosphoric acid" [EC:4.2.3.-]
xref: MetaCyc:RXN-13522
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0102483
name: scopolin beta-glucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + scopolin <=> beta-D-glucose + scopoletin" [EC:3.2.1.21]
xref: EC:3.2.1.21
xref: MetaCyc:RXN-14179
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0102484
name: esculetin glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: esculetin + UDP-alpha-D-glucose(2-) <=> esculin + UDP(3-) + H+" [EC:2.4.1.-]
xref: MetaCyc:RXN-14182
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0102580
name: cyanidin 3-O-glucoside 2-O''-xylosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + UDP-alpha-D-xylose <=> cyanidin 3-O-beta-D-sambubioside + UDP" [EC:2.4.2.51]
xref: EC:2.4.2.51
xref: MetaCyc:RXN-15326
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0102581
name: cyanidin 3-O-glucoside-p-coumaroyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 4-coumaryl-CoA + H+ <=> cyanidin 3-O-(6-O-(E)-4-coumaroyl-beta-D-glucoside) + coenzyme A" [EC:2.3.1.-]
xref: MetaCyc:RXN-15327
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0102582
name: cyanidin 3-O-p-coumaroylglucoside 2-O''-xylosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyanidin 3-O-(6-O-(E)-4-coumaroyl-beta-D-glucoside) + UDP-alpha-D-xylose <=> cyanidin 3-O-[2" [EC:2.4.2.-]
xref: MetaCyc:RXN-15328
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0102583
name: cyanidin 3-O-glucoside-(2\"-O-xyloside) 6''-O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyanidin 3-O-beta-D-sambubioside + 4-coumaryl-CoA <=> cyanidin 3-O-[2" [EC:2.3.1.-]
xref: MetaCyc:RXN-15329
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0102584
name: cyanidin 3-O-[2\"-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-glucosyltransferase activity 5-O-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyanidin 3-O-[2''-O-xylosyl) 6''-O-(p-coumaroyl) glucoside + UDP-alpha-D-glucose <=> cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-glucoside + UDP + H+" [EC:2.4.1-]
xref: MetaCyc:RXN-15330
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0102585
name: cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-glucoside malonyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-glucoside + malonyl-CoA + H+ <=> cyanidin 3-O-[2''	-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-malonylglucoside + coenzyme A." [EC:2.3.1-]
xref: MetaCyc:RXN-15331
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0102586
name: cyanidin 3-O-[2''-O-(2''-O-(sinapoyl) xylosyl) 6''-O-(p-coumaroyl) glucoside] 5-O-[6''-O-(malonyl) glucoside] sinapoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-malonylglucoside + 1-O-sinapoyl-beta-D-glucose <=> cyanidin 3-O-[2''-O-(2''-O-(sinapoyl) xylosyl) 6'-O-(p-coumaroyl) glucoside] 5-O-[6''-O-(malonyl) glucoside + beta-D-glucose." [EC:2.3.1.-]
xref: MetaCyc:RXN-15332
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0102587
name: cyanidin 3-O-[2''-O-(2''-O-(sinapoyl) xylosyl) 6''-O-(p-O-(glucosyl)-p-coumaroyl) glucoside] 5-O-[6''-O-(malonyl) glucoside] sinapoylglucose glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyanidin 3-O-[2''-O-(2'''-O-(sinapoyl) xylosyl) 6''-O-(p-coumaroyl) glucoside] 5-O-[6''-O-(malonyl) glucoside + 1-O-sinapoyl-beta-D-glucose <=> cyanidin 3-O-[6-O-(4-O-beta-D-glucosyl-p-coumaroyl)-2-O-(2-O-sinapoyl-beta-D-xylosyl)-beta-D-glucosyl]-5-O-(6-O-malonyl-beta-D-glucoside) + trans-sinapate + H+." [EC:2.4.1.-]
xref: MetaCyc:RXN-15333
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0102588
name: cyanidin 3-O-glucoside 6''-O-malonyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + malonyl-CoA <=> cyanidin 3-O-(6-O-malonyl-beta-D-glucoside) + coenzyme A." [EC:2.3.1.171]
xref: EC:2.3.1.171
xref: MetaCyc:RXN-15335
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0102589
name: cyanidin 3-O-glucoside 3'',6''-O-dimalonyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyanidin 3-O-(6-O-malonyl-beta-D-glucoside) + malonyl-CoA(5-) <=> cyanidin 3-O-(3''', 6''-O-dimalonyl-beta-glucopyranoside) + coenzyme A" [EC:2.3.1.-]
xref: MetaCyc:RXN-15336
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0102613
name: trimethyluric acid monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,3,7-trimethyluric acid + O2 + NADH + 3 H+ <=> 1,3,7-trimethyl-5-hydroxyisourate + NAD + H2O" [EC:1.14.13.-]
xref: MetaCyc:RXN-15454
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102614
name: germacrene A acid 8beta-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: germacra-1(10),4,11(13)-trien-12-oate + NADPH + O2 + H+ <=> 8beta-hydroxy-germacra-1(10),4,11(13)-trien-12-oate + NADP + H2O" [EC:1.14.13.-]
xref: MetaCyc:RXN-15460
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0102622
name: linuron hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: linuron + H2O <=> N,O-dimethylhydroxylamine + carbon dioxide + 3,4-dichloroaniline" [EC:3.5.1.-]
xref: MetaCyc:RXN-15526
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0102623
name: scutellarein 7-methyl ether 6-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: scutellarein 7-methyl ether + S-adenosyl-L-methionine  <=> cirsimaritin + S-adenosyl-L-homocysteine  + H+" [EC:2.1.1.-]
xref: MetaCyc:RXN-15528
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102624
name: scutellarein 7-methyl ether 4'-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: scutellarein 7-methyl ether + S-adenosyl-L-methionine  <=> ladanein + S-adenosyl-L-homocysteine  + H+" [EC:2.1.1.-]
xref: MetaCyc:RXN-15529
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102625
name: cirsimaritin 4'-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: cirsimaritin + S-adenosyl-L-methionine  <=> salvigenin + S-adenosyl-L-homocysteine  + H+" [EC:2.1.1.-]
xref: MetaCyc:RXN-15530
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0102737
name: p-coumaroyltriacetic acid synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 H+ + 4-coumaryl-CoA + H2O + 3 malonyl-CoA <=> 4 coenzyme A + 3 carbon dioxide + p-coumaroyltriacetate" [EC:2.3.1.-]
xref: MetaCyc:RXN-7577
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0102738
name: (gibberellin-14), 2-oxoglutarate:oxygen oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: gibberellin A14 + O2 + 2-oxoglutarate <=> gibberellin A37 + carbon dioxide + succinate" [EC:1.14.11.-]
xref: MetaCyc:RXN-7589
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0102739
name: (gibberellin-36), 2-oxoglutarate:oxygen oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: gibberellin A36 + O2 + 2-oxoglutarate <=> H+ + gibberellin A4 + succinate + 2 carbon dioxide" [EC:1.14.11.-]
xref: MetaCyc:RXN-7591
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0103005
name: 9,10-epoxystearate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 9,10-epoxystearate + H2O <=> (9R,10S)-dihydroxystearate" [EC:3.3.2.-]
xref: MetaCyc:RXN-9806
is_a: GO:0016803 ! ether hydrolase activity

[Term]
id: GO:0103011
name: mannosylfructose-phosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-alpha-D-mannose + beta-D-fructofuranose 6-phosphate <=> mannosylfructose-phosphate + GDP" [EC:2.4.1.246]
xref: EC:2.4.1.246
xref: MetaCyc:RXN-9935
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0103019
name: undecaprenyl phosphate-L-Ara4FN transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-4-deoxy-4-formamido-beta-L-arabinopyranose + ditrans,polycis-undecaprenyl phosphate <=> 4-deoxy-4-formamido-alpha-L-arabinopyranosyl ditrans,polycis-undecaprenyl phosphate + UDP" [EC:2.4.2.53]
xref: EC:2.4.2.53
xref: MetaCyc:RXN0-3521
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0103032
name: tartronate semialdehyde reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glycerate + NAD <=> H+ + 2-hydroxy-3-oxopropanoate + NADH" [EC:1.1.1.-]
xref: MetaCyc:RXN0-5289
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0103042
name: 4-hydroxy-L-threonine aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxy-L-threonine <=> glycolaldehyde + glycine" [EC:4.1.2.-]
xref: MetaCyc:RXN0-6563
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0103054
name: gibberellin A12, 2-oxoglutarate:oxygen oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: gibberellin A12 + O2 + 2-oxoglutarate <=> gibberellin A15 + carbon dioxide + succinate" [EC:1.14.11.-]
xref: MetaCyc:RXN1F-162
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0103055
name: gibberelli A15, 2-oxoglutarate:oxygen oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: gibberellin A15 + 2-oxoglutarate + O2 <=> gibberellin A24 + succinate + carbon dioxide + H2O" [EC:1.14.11.-]
xref: MetaCyc:RXN1F-163
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0103056
name: gibberellin A53, 2-oxoglutarate:oxygen oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: gibberellin A53 + O2 + 2-oxoglutarate <=> gibberellin A44 diacid + carbon dioxide + succinate" [EC:1.14.11.-]
xref: MetaCyc:RXN1F-167
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0103057
name: gibberellin A19, 2-oxoglutarate:oxygen oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: gibberellin A19 + O2 + 2-oxoglutarate <=> H+ + gibberellin A20 + 2 carbon dioxide + succinate" [EC:1.14.11.-]
xref: MetaCyc:RXN1F-169
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0103058
name: kaempferol 3-glucoside 7-O-rhamnosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: kaempferol 3-O-glucoside + UDP-L-rhamnose <=> kaempferol-3-glucoside-7-rhamnoside + UDP" [EC:2.4.1.-]
xref: MetaCyc:RXN1F-443
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0103059
name: UDP-L-rhamnose:kaempferol 3-O-rhamnosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: kaempferol oxoanion + UDP-L-rhamnose <=> H+ + kaempferol-3-rhamnoside + UDP(3-)" [EC:2.4.1.-]
xref: MetaCyc:RXN1F-474
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0103060
name: kaempferol 3-rhamnoside 7-O-rhamnosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: kaempferol-3-rhamnoside + UDP-L-rhamnose <=> kaempferol-3-rhamnoside-7-rhamnoside + UDP." [EC:2.4.1.-]
xref: MetaCyc:RXN1F-475
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0103061
name: trans-methoxy-C60-meroacyl-AMP ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP(4-) + H2O + a trans-methoxy-C60-meroacyl-[acp] <=> diphosphoric acid + a trans-methoxy-meroacyl-adenylate + a holo-[acyl-carrier protein]" [EC:6.2.1.-]
xref: MetaCyc:RXN1G-4141
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0103062
name: cis-keto-C60-meroacyl-AMP ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP(4-) + H2O + a cis-keto-C60-meroacyl-[acp] <=> diphosphoric acid + a cis-keto-meroacyl-adenylate + a holo-[acyl-carrier protein]" [EC:6.2.1.-]
xref: MetaCyc:RXN1G-4142
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0103063
name: trans-keto-C61-meroacyl-AMP ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP(4-) + H2O + a trans-keto-C61-meroacyl-[acp] <=> diphosphoric acid + a trans-keto-meroacyl-adenylate + a holo-[acyl-carrier protein]" [EC:6.2.1.-]
xref: MetaCyc:RXN1G-4143
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0103069
name: 17-hydroxyprogesterone 21-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 17alpha-hydroxyprogesterone + NADPH + H+ + O2 <=> NADP + H2O + 11-deoxycortisol" [EC:1.14.13.-]
xref: MetaCyc:RXN66-356
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0103073
name: anandamide amidohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: anandamide + H2O <=> arachidonate + ethanolaminium(1+)" [EC:3.5.1.99]
xref: EC:3.5.1.99
xref: MetaCyc:RXN6666-2
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0103075
name: indole-3-pyruvate monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-(indol-3-yl)pyruvate + NADPH + O2 + H+ <=> indole-3-acetate + carbon dioxide + NADP + H2O" [EC:1.14.13.168]
xref: EC:1.14.13.168
xref: MetaCyc:RXNDQC-2
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0103077
name: quercetin 3-glucoside 7-O-rhamnosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: quercetin-3-glucoside + UDP-L-rhamnose <=> quercetin-3-O-glucoside-7-O-rhamnoside + UDP(3-)" [EC:2.4.1.-]
xref: MetaCyc:RXNQT-4161
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0103078
name: quercetin 3-rhamnoside 7-O-rhamnosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + quercetin 3-O-rhamnoside + UDP-L-rhamnose <=> quercetin-3-rhamnoside-7-rhamnoside + UDP(3-)" [EC:2.4.1.-]
xref: MetaCyc:RXNQT-4162
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0103079
name: 2-(3'-methylthio)propylmalate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-methylthio-2-oxopentanoate + acetyl-CoA(4-) + H2O <=> H+ + 2-(3-methylthiopropyl)malate(2-) + coenzyme A(4-)" [EC:2.3.3.-]
xref: MetaCyc:RXNQT-4163
is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

[Term]
id: GO:0103082
name: 2-(4'-methylthio)butylmalate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxo-6-methylthiohexanoate + acetyl-CoA(4-) + H2O <=> H+ + 2-(4'-methylthio)butylmalate + coenzyme A(4-)" [EC:2.3.3.-]
xref: MetaCyc:RXNQT-4166
is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

[Term]
id: GO:0103085
name: 2-(5'-methylthio)pentylmalate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxo-7-methylthioheptanoate + acetyl-CoA(4-) + H2O <=> H+ + 2-(5'-methylthio)pentylmalate + coenzyme A(4-)" [EC:2.3.3.-]
xref: MetaCyc:RXNQT-4169
is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

[Term]
id: GO:0103088
name: 2-(6'-methylthio)hexylmalate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxo-8-methylthiooctanoate + acetyl-CoA(4-) + H2O <=> H+ + 2-(6'-methylthio)hexylmalate + coenzyme A(4-)" [EC:2.3.3.-]
xref: MetaCyc:RXNQT-4172
is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

[Term]
id: GO:0103091
name: 2-(7'-methylthio)heptylmalate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxo-9-methylthiononanoate + acetyl-CoA(4-) + H2O <=> H+ + 2-(7'-methylthio)heptylmalate + coenzyme A(4-)" [EC:2.3.3.-]
xref: MetaCyc:RXNQT-4175
is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

[Term]
id: GO:0103092
name: methylthioalkylmalate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-(7'-methylthio)heptylmalate <=> 3-(7'-methylthio)heptylmalate" [EC:5.4.4.-]
xref: MetaCyc:RXNQT-4176
is_a: GO:0050486 ! intramolecular transferase activity, transferring hydroxy groups

[Term]
id: GO:0103093
name: methylthioalkylmalate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-(7'-methylthio)heptylmalate <=> H+ + 2-oxo-10-methylthiodecanoate + carbon dioxide" [EC:1.1.1.-]
xref: MetaCyc:RXNQT-4178
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0103095
name: wax ester synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: a very long chain alcohol + a long-chain acyl-CoA <=> coenzyme A(4-) + a wax ester" [EC:2.3.1.75]
xref: EC:2.3.1.75
xref: MetaCyc:RXNQT-4193
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0103096
name: CYP79F1 dihomomethionine monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: dihomomethionine + 2 O2 + 2 NADPH(4-) + 2 H+ <=> 5-methylthiopentanaldoxime + 3 H2O + carbon dioxide + 2 NADP(3-)" [EC:1.14.13.-]
xref: MetaCyc:RXNQT-4309
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0103097
name: CYP79F1 trihomomethionine monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: trihomomethionine + 2 O2 + 2 NADPH(4-) + 2 H+ <=> 3 H2O + carbon dioxide + 2 NADP(3-) + 6-methylthiohexanaldoxime" [EC:1.14.13.-]
xref: MetaCyc:RXNQT-4310
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0103098
name: CYP79F1 tetrahomomethionine monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 H+ + tetrahomomethionine + 2 O2 + 2 NADPH(4-) <=> 3 H2O + carbon dioxide + 2 NADP(3-) + 7-methylthioheptanaldoxime" [EC:1.14.13.-]
xref: MetaCyc:RXNQT-4311
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0103099
name: UDP-glucose:5-methylthiopentylhydroximate S-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-alpha-D-glucose(2-) + 5-methylthiopentylhydroximate <=> H+ + 4-methylthiobutyldesulfoglucosinolate + UDP(3-)" [EC:2.4.1.195]
xref: EC:2.4.1.195
xref: MetaCyc:RXNQT-4324
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0103100
name: UDP-glucose: 6-methylthiohexylhydroximate S-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-alpha-D-glucose(2-) + 6-methylthiohexylhydroximate <=> H+ + 5-methylthiopentyldesulfoglucosinolate + UDP(3-)" [EC:2.4.1.195]
xref: EC:2.4.1.195
xref: MetaCyc:RXNQT-4325
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0103101
name: UDP-glucose:7-methylthioheptylhydroximate S-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-alpha-D-glucose(2-) + 7-methylthioheptylhydroximate <=> H+ + 6-methylthiohexyldesulfoglucosinolate + UDP(3-)" [EC:2.4.1.195]
xref: EC:2.4.1.195
xref: MetaCyc:RXNQT-4326
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0103102
name: UDP-glucose:8-methylthiooctylhydroximate S-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-alpha-D-glucose(2-) + 8-methylthiooctylhydroximate <=> H+ + 7-methylthioheptyldesulfoglucosinolate + UDP(3-)" [EC:2.4.1.195]
xref: EC:2.4.1.195
xref: MetaCyc:RXNQT-4327
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0103103
name: UDP-glucose: 9-methylthiononylhydroximate S-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-alpha-D-glucose(2-) + 9-methylthiononylhydroximate <=> 8-methylthiooctyldesulfoglucosinolate + UDP(3-) + H+" [EC:2.4.1.195]
xref: EC:2.4.1.195
xref: MetaCyc:RXNQT-4328
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0103104
name: 6-methylthiohexyldesulfoglucosinolate sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-methylthiohexyldesulfoglucosinolate + 3'-phosphonato-5'-adenylyl sulfate(4-) <=> adenosine 3',5'-bismonophosphate(4-) + H+ + 6-methylthiohexylglucosinolate" [EC:2.8.2.-]
xref: MetaCyc:RXNQT-4331
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0103105
name: 2-oxo-6-methylthiohexanoate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxo-6-methylthiohexanoate + a standard alpha amino acid <=> dihomomethionine + a 2-oxo carboxylate" [EC:2.6.1.-]
xref: MetaCyc:RXNQT-4345
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0103106
name: brassinolide 23-O-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: brassinolide + UDP-alpha-D-glucose(2-) <=> brassinolide-23-O-glucoside + UDP(3-) + H+" [EC:2.4.1.-]
xref: MetaCyc:RXNQT-4397
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0103107
name: castasterone 23-O-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: castasterone + UDP-alpha-D-glucose(2-) <=> castasterone-23-O-glucoside + UDP(3-) + H+" [EC:2.4.1.-]
xref: MetaCyc:RXNQT-4398
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0103111
name: D-glucosamine PTS permease activity
namespace: molecular_function
def: "Catalysis of the reaction: a [PTS enzyme I]-Npi-phospho-L-histidine + D-glucosamine <=> D-glucosamine 6-phosphate + a [PTS enzyme I]-L-histidine" [EC:2.7.1.69]
xref: EC:2.7.1.69
xref: MetaCyc:TRANS-RXN-167A
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0103113
name: glucosyl-oleandomycin-exporting ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: glucosyl-oleandomycin + ATP(4-) + H2O <=> glucosyl-oleandomycin + ADP(3-) + hydrogenphosphate + H+" [EC:3.6.3.-]
xref: MetaCyc:TRANS-RXN-220
is_a: GO:0016820 ! hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances

[Term]
id: GO:0103115
name: protoheme IX ABC transporter activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP(4-) + H2O + heme b <=> hydrogenphosphate + ADP(3-) + H+ + heme b" [EC:3.6.3.41]
xref: EC:3.6.3.41
xref: MetaCyc:TRANS-RXN0-162
is_a: GO:0016820 ! hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances

[Term]
id: GO:0103116
name: alpha-D-galactofuranose transporter activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-galactofuranose + ATP(4-) + H2O <=> alpha-D-galactofuranose + hydrogenphosphate + ADP(3-) + H+" [EC:3.6.3.-]
xref: EC:3.6.3.-
xref: MetaCyc:TRANS-RXN0-491
is_a: GO:0016820 ! hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances

[Term]
id: GO:0103117
name: UDP-3-O-acyl-N-acetylglucosamine deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetylglucosamine(2-) + H2O <=> UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine(1-) + acetate" [EC:3.5.1.108]
xref: EC:3.5.1.108
xref: MetaCyc:UDPACYLGLCNACDEACETYL-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0103118
name: UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine(1-) + an (3R)-3-hydroxymyristoyl-[acp] <=> UDP-2,3-bis[O-(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + H+ + a holo-[acyl-carrier protein]" [EC:2.3.1.191]
xref: EC:2.3.1.191
xref: MetaCyc:UDPHYDROXYMYRGLUCOSAMNACETYLTRANS-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:1900000
name: regulation of anthocyanin catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of anthocyanin catabolic process." [GOC:TermGenie]
synonym: "regulation of anthocyanin breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of anthocyanin catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of anthocyanin degradation" EXACT [GOC:TermGenie]
is_a: GO:0009894 ! regulation of catabolic process
is_a: GO:0031537 ! regulation of anthocyanin metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0046284 ! anthocyanin-containing compound catabolic process
relationship: regulates GO:0046284 ! anthocyanin-containing compound catabolic process
created_by: tb
creation_date: 2011-12-20T07:12:07Z

[Term]
id: GO:1900001
name: negative regulation of anthocyanin catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of anthocyanin catabolic process." [GOC:TermGenie]
synonym: "down regulation of anthocyanin breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of anthocyanin catabolic process" RELATED [GOC:TermGenie]
synonym: "down regulation of anthocyanin catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of anthocyanin degradation" EXACT [GOC:TermGenie]
synonym: "negative regulation of anthocyanin breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of anthocyanin catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of anthocyanin degradation" EXACT [GOC:TermGenie]
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0031538 ! negative regulation of anthocyanin metabolic process
is_a: GO:1900000 ! regulation of anthocyanin catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0046284 ! anthocyanin-containing compound catabolic process
relationship: negatively_regulates GO:0046284 ! anthocyanin-containing compound catabolic process
created_by: tb
creation_date: 2011-12-20T07:12:11Z

[Term]
id: GO:1900002
name: positive regulation of anthocyanin catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of anthocyanin catabolic process." [GOC:TermGenie]
synonym: "positive regulation of anthocyanin breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of anthocyanin catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of anthocyanin degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of anthocyanin breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of anthocyanin catabolic process" RELATED [GOC:TermGenie]
synonym: "up regulation of anthocyanin catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of anthocyanin degradation" EXACT [GOC:TermGenie]
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0031539 ! positive regulation of anthocyanin metabolic process
is_a: GO:1900000 ! regulation of anthocyanin catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0046284 ! anthocyanin-containing compound catabolic process
relationship: positively_regulates GO:0046284 ! anthocyanin-containing compound catabolic process
created_by: tb
creation_date: 2011-12-20T07:12:15Z

[Term]
id: GO:1900003
name: regulation of serine-type endopeptidase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of serine-type endopeptidase activity." [GOC:TermGenie]
synonym: "regulation of blood coagulation factor activity" RELATED [GOC:TermGenie]
is_a: GO:0052548 ! regulation of endopeptidase activity
is_a: GO:1902571 ! regulation of serine-type peptidase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004252 ! serine-type endopeptidase activity
relationship: regulates GO:0004252 ! serine-type endopeptidase activity
created_by: kmv
creation_date: 2012-01-09T10:03:15Z

[Term]
id: GO:1900004
name: negative regulation of serine-type endopeptidase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of serine-type endopeptidase activity." [GOC:TermGenie]
synonym: "down regulation of blood coagulation factor activity" RELATED [GOC:TermGenie]
synonym: "down regulation of serine-type endopeptidase activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of blood coagulation factor activity" RELATED [GOC:TermGenie]
is_a: GO:0010951 ! negative regulation of endopeptidase activity
is_a: GO:1900003 ! regulation of serine-type endopeptidase activity
is_a: GO:1902572 ! negative regulation of serine-type peptidase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004252 ! serine-type endopeptidase activity
relationship: negatively_regulates GO:0004252 ! serine-type endopeptidase activity
created_by: kmv
creation_date: 2012-01-09T10:03:20Z

[Term]
id: GO:1900005
name: positive regulation of serine-type endopeptidase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of serine-type endopeptidase activity." [GOC:TermGenie]
synonym: "positive regulation of blood coagulation factor activity" RELATED [GOC:TermGenie]
synonym: "up regulation of blood coagulation factor activity" RELATED [GOC:TermGenie]
synonym: "up regulation of serine-type endopeptidase activity" RELATED [GOC:TermGenie]
is_a: GO:0010950 ! positive regulation of endopeptidase activity
is_a: GO:1900003 ! regulation of serine-type endopeptidase activity
is_a: GO:1902573 ! positive regulation of serine-type peptidase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004252 ! serine-type endopeptidase activity
relationship: positively_regulates GO:0004252 ! serine-type endopeptidase activity
created_by: kmv
creation_date: 2012-01-09T10:03:29Z

[Term]
id: GO:1900006
name: positive regulation of dendrite development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of dendrite development." [GOC:TermGenie]
synonym: "up regulation of dendrite development" RELATED [GOC:TermGenie]
is_a: GO:0010976 ! positive regulation of neuron projection development
is_a: GO:0050773 ! regulation of dendrite development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016358 ! dendrite development
relationship: positively_regulates GO:0016358 ! dendrite development
created_by: hjd
creation_date: 2012-01-09T10:41:31Z

[Term]
id: GO:1900007
name: regulation of extrachromosomal rDNA circle accumulation involved in replicative cell aging
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of extrachromosomal rDNA circle accumulation involved in replicative cell aging." [GOC:TermGenie, PMID:15020466]
synonym: "regulation of extrachromosomal rDNA circle accumulation during replicative cell ageing" RELATED [GOC:TermGenie]
synonym: "regulation of extrachromosomal rDNA circle accumulation during replicative cell aging" RELATED [GOC:TermGenie]
synonym: "regulation of extrachromosomal ribosomal DNA circle accumulation during replicative cell aging" RELATED [GOC:TermGenie]
is_a: GO:1900062 ! regulation of replicative cell aging
is_a: GO:1903308 ! regulation of chromatin modification
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001310 ! extrachromosomal rDNA circle accumulation involved in replicative cell aging
relationship: regulates GO:0001310 ! extrachromosomal rDNA circle accumulation involved in replicative cell aging
created_by: se
creation_date: 2012-01-09T10:44:07Z

[Term]
id: GO:1900008
name: negative regulation of extrachromosomal rDNA circle accumulation involved in replicative cell aging
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of extrachromosomal rDNA circle accumulation involved in replicative cell aging." [GOC:TermGenie, PMID:15020466]
synonym: "down regulation of extrachromosomal rDNA circle accumulation during replicative cell ageing" RELATED [GOC:TermGenie]
synonym: "down regulation of extrachromosomal rDNA circle accumulation during replicative cell aging" RELATED [GOC:TermGenie]
synonym: "down regulation of extrachromosomal rDNA circle accumulation involved in replicative cell aging" RELATED [GOC:TermGenie]
synonym: "down regulation of extrachromosomal ribosomal DNA circle accumulation during replicative cell aging" RELATED [GOC:TermGenie]
synonym: "negative regulation of extrachromosomal rDNA circle accumulation during replicative cell ageing" RELATED [GOC:TermGenie]
synonym: "negative regulation of extrachromosomal rDNA circle accumulation during replicative cell aging" RELATED [GOC:TermGenie]
synonym: "negative regulation of extrachromosomal ribosomal DNA circle accumulation during replicative cell aging" RELATED [GOC:TermGenie]
is_a: GO:0090344 ! negative regulation of cell aging
is_a: GO:1900007 ! regulation of extrachromosomal rDNA circle accumulation involved in replicative cell aging
is_a: GO:1903309 ! negative regulation of chromatin modification
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001310 ! extrachromosomal rDNA circle accumulation involved in replicative cell aging
relationship: negatively_regulates GO:0001310 ! extrachromosomal rDNA circle accumulation involved in replicative cell aging
created_by: se
creation_date: 2012-01-09T10:44:10Z

[Term]
id: GO:1900009
name: positive regulation of extrachromosomal rDNA circle accumulation involved in replicative cell aging
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of extrachromosomal rDNA circle accumulation involved in replicative cell aging." [GOC:TermGenie, PMID:15020466]
synonym: "positive regulation of extrachromosomal rDNA circle accumulation during replicative cell ageing" RELATED [GOC:TermGenie]
synonym: "positive regulation of extrachromosomal rDNA circle accumulation during replicative cell aging" RELATED [GOC:TermGenie]
synonym: "positive regulation of extrachromosomal ribosomal DNA circle accumulation during replicative cell aging" RELATED [GOC:TermGenie]
synonym: "up regulation of extrachromosomal rDNA circle accumulation during replicative cell ageing" RELATED [GOC:TermGenie]
synonym: "up regulation of extrachromosomal rDNA circle accumulation during replicative cell aging" RELATED [GOC:TermGenie]
synonym: "up regulation of extrachromosomal rDNA circle accumulation involved in replicative cell aging" RELATED [GOC:TermGenie]
synonym: "up regulation of extrachromosomal ribosomal DNA circle accumulation during replicative cell aging" RELATED [GOC:TermGenie]
is_a: GO:0090343 ! positive regulation of cell aging
is_a: GO:1900007 ! regulation of extrachromosomal rDNA circle accumulation involved in replicative cell aging
is_a: GO:1903310 ! positive regulation of chromatin modification
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001310 ! extrachromosomal rDNA circle accumulation involved in replicative cell aging
relationship: positively_regulates GO:0001310 ! extrachromosomal rDNA circle accumulation involved in replicative cell aging
created_by: se
creation_date: 2012-01-09T10:44:18Z

[Term]
id: GO:1900010
name: regulation of corticotropin-releasing hormone receptor activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of corticotropin-releasing hormone receptor activity." [GOC:TermGenie, GOC:yaf, PMID:18234674]
synonym: "regulation of adrenocorticotropin-releasing hormone receptor activity" EXACT [GOC:TermGenie]
synonym: "regulation of corticotropin-releasing factor receptor activity" EXACT [GOC:TermGenie]
synonym: "regulation of CRF receptor activity" EXACT [GOC:TermGenie]
synonym: "regulation of CRH receptor activity" EXACT [GOC:TermGenie]
is_a: GO:0010469 ! regulation of receptor activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043404 ! corticotropin-releasing hormone receptor activity
relationship: regulates GO:0043404 ! corticotropin-releasing hormone receptor activity
created_by: pr
creation_date: 2012-01-10T02:27:23Z

[Term]
id: GO:1900011
name: negative regulation of corticotropin-releasing hormone receptor activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of corticotropin-releasing hormone receptor activity." [GOC:TermGenie, GOC:yaf, PMID:18234674]
synonym: "down regulation of adrenocorticotropin-releasing hormone receptor activity" EXACT [GOC:TermGenie]
synonym: "down regulation of corticotropin-releasing factor receptor activity" EXACT [GOC:TermGenie]
synonym: "down regulation of corticotropin-releasing hormone receptor activity" RELATED [GOC:TermGenie]
synonym: "down regulation of CRF receptor activity" EXACT [GOC:TermGenie]
synonym: "down regulation of CRH receptor activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of adrenocorticotropin-releasing hormone receptor activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of corticotropin-releasing factor receptor activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of CRF receptor activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of CRH receptor activity" EXACT [GOC:TermGenie]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:1900010 ! regulation of corticotropin-releasing hormone receptor activity
is_a: GO:2000272 ! negative regulation of receptor activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043404 ! corticotropin-releasing hormone receptor activity
relationship: negatively_regulates GO:0043404 ! corticotropin-releasing hormone receptor activity
created_by: pr
creation_date: 2012-01-10T02:27:27Z

[Term]
id: GO:1900012
name: positive regulation of corticotropin-releasing hormone receptor activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of corticotropin-releasing hormone receptor activity." [GOC:TermGenie, GOC:yaf, PMID:18234674]
synonym: "positive regulation of adrenocorticotropin-releasing hormone receptor activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of corticotropin-releasing factor receptor activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of CRF receptor activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of CRH receptor activity" EXACT [GOC:TermGenie]
synonym: "up regulation of adrenocorticotropin-releasing hormone receptor activity" EXACT [GOC:TermGenie]
synonym: "up regulation of corticotropin-releasing factor receptor activity" EXACT [GOC:TermGenie]
synonym: "up regulation of corticotropin-releasing hormone receptor activity" RELATED [GOC:TermGenie]
synonym: "up regulation of CRF receptor activity" EXACT [GOC:TermGenie]
synonym: "up regulation of CRH receptor activity" EXACT [GOC:TermGenie]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:1900010 ! regulation of corticotropin-releasing hormone receptor activity
is_a: GO:2000273 ! positive regulation of receptor activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043404 ! corticotropin-releasing hormone receptor activity
relationship: positively_regulates GO:0043404 ! corticotropin-releasing hormone receptor activity
created_by: pr
creation_date: 2012-01-10T02:27:30Z

[Term]
id: GO:1900013
name: obsolete cellular response to potassium ion involved in chemotaxis to cAMP
namespace: biological_process
def: "OBSOLETE. The directed movement of a motile cell in response to the presence of 3',5'-cAMP that results in a change in state or activity (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus." [GOC:pf, GOC:TermGenie, PMID:19363786, PMID:21239624]
comment: This term was made obsolete because it was added by mistake.
synonym: "cellular response to K+ ion of chemotaxis to 3',5' cAMP" EXACT [GOC:TermGenie]
synonym: "cellular response to K+ ion of chemotaxis to 3',5'-cAMP" EXACT [GOC:TermGenie]
synonym: "cellular response to K+ ion of chemotaxis to adenosine 3',5'-cyclophosphate" EXACT [GOC:TermGenie]
synonym: "cellular response to K+ ion of chemotaxis to cAMP" RELATED [GOC:TermGenie]
synonym: "cellular response to K+ ion of chemotaxis to cyclic AMP" EXACT [GOC:TermGenie]
synonym: "cellular response to potassium ion involved in chemotaxis to cAMP" EXACT []
synonym: "cellular response to potassium ion of chemotaxis to 3',5' cAMP" RELATED [GOC:TermGenie]
synonym: "cellular response to potassium ion of chemotaxis to 3',5'-cAMP" RELATED [GOC:TermGenie]
synonym: "cellular response to potassium ion of chemotaxis to adenosine 3',5'-cyclophosphate" RELATED [GOC:TermGenie]
synonym: "cellular response to potassium ion of chemotaxis to cAMP" RELATED [GOC:TermGenie]
synonym: "cellular response to potassium ion of chemotaxis to cyclic AMP" RELATED [GOC:TermGenie]
synonym: "cellular response to potassium of chemotaxis to 3',5' cAMP" EXACT [GOC:TermGenie]
synonym: "cellular response to potassium of chemotaxis to 3',5'-cAMP" EXACT [GOC:TermGenie]
synonym: "cellular response to potassium of chemotaxis to adenosine 3',5'-cyclophosphate" EXACT [GOC:TermGenie]
synonym: "cellular response to potassium of chemotaxis to cAMP" RELATED [GOC:TermGenie]
synonym: "cellular response to potassium of chemotaxis to cyclic AMP" EXACT [GOC:TermGenie]
is_obsolete: true
created_by: pr
creation_date: 2012-01-11T07:59:57Z

[Term]
id: GO:1900014
name: obsolete cellular response to calcium ion involved in chemotaxis to cAMP
namespace: biological_process
def: "The directed movement of a motile cell in response to the presence of 3',5'-cAMP that results in a change in state or activity (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:pf, GOC:TermGenie, PMID:19363786, PMID:21239624, PMID:8937985]
synonym: "cellular response to Ca2+ ion of chemotaxis to 3',5' cAMP" EXACT [GOC:TermGenie]
synonym: "cellular response to Ca2+ ion of chemotaxis to 3',5'-cAMP" EXACT [GOC:TermGenie]
synonym: "cellular response to Ca2+ ion of chemotaxis to adenosine 3',5'-cyclophosphate" EXACT [GOC:TermGenie]
synonym: "cellular response to Ca2+ ion of chemotaxis to cAMP" RELATED [GOC:TermGenie]
synonym: "cellular response to Ca2+ ion of chemotaxis to cyclic AMP" EXACT [GOC:TermGenie]
synonym: "cellular response to calcium ion involved in chemotaxis to cAMP" EXACT []
synonym: "cellular response to calcium ion of chemotaxis to 3',5' cAMP" RELATED [GOC:TermGenie]
synonym: "cellular response to calcium ion of chemotaxis to 3',5'-cAMP" RELATED [GOC:TermGenie]
synonym: "cellular response to calcium ion of chemotaxis to adenosine 3',5'-cyclophosphate" RELATED [GOC:TermGenie]
synonym: "cellular response to calcium ion of chemotaxis to cAMP" RELATED [GOC:TermGenie]
synonym: "cellular response to calcium ion of chemotaxis to cyclic AMP" RELATED [GOC:TermGenie]
is_obsolete: true
created_by: pr
creation_date: 2012-01-11T08:06:58Z

[Term]
id: GO:1900015
name: regulation of cytokine production involved in inflammatory response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cytokine production involved in inflammatory response." [GOC:TermGenie]
synonym: "regulation of cytokine production involved in acute inflammatory response" NARROW [GOC:TermGenie]
is_a: GO:0001817 ! regulation of cytokine production
is_a: GO:0050727 ! regulation of inflammatory response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002534 ! cytokine production involved in inflammatory response
relationship: regulates GO:0002534 ! cytokine production involved in inflammatory response
created_by: rph
creation_date: 2012-01-11T09:34:27Z

[Term]
id: GO:1900016
name: negative regulation of cytokine production involved in inflammatory response
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytokine production involved in inflammatory response." [GOC:TermGenie]
synonym: "down regulation of cytokine production involved in acute inflammatory response" BROAD [GOC:TermGenie]
synonym: "down regulation of cytokine production involved in inflammatory response" RELATED [GOC:TermGenie]
synonym: "negative regulation of cytokine production involved in acute inflammatory response" NARROW [GOC:TermGenie]
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0050728 ! negative regulation of inflammatory response
is_a: GO:1900015 ! regulation of cytokine production involved in inflammatory response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002534 ! cytokine production involved in inflammatory response
relationship: negatively_regulates GO:0002534 ! cytokine production involved in inflammatory response
created_by: rph
creation_date: 2012-01-11T09:34:31Z

[Term]
id: GO:1900017
name: positive regulation of cytokine production involved in inflammatory response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cytokine production involved in inflammatory response." [GOC:TermGenie]
synonym: "positive regulation of cytokine production involved in acute inflammatory response" NARROW [GOC:TermGenie]
synonym: "up regulation of cytokine production involved in acute inflammatory response" BROAD [GOC:TermGenie]
synonym: "up regulation of cytokine production involved in inflammatory response" RELATED [GOC:TermGenie]
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0050729 ! positive regulation of inflammatory response
is_a: GO:1900015 ! regulation of cytokine production involved in inflammatory response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002534 ! cytokine production involved in inflammatory response
relationship: positively_regulates GO:0002534 ! cytokine production involved in inflammatory response
created_by: rph
creation_date: 2012-01-11T09:34:35Z

[Term]
id: GO:1900018
name: phosphorylation of RNA polymerase II C-terminal domain serine 5 residues involved in recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex
namespace: biological_process
def: "Any phosphorylation of RNA polymerase II C-terminal domain serine 5 residues that is involved in recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex." [GOC:rb, GOC:TermGenie, PMID:10594013, PMID:19666497]
is_a: GO:0071620 ! phosphorylation of RNA polymerase II C-terminal domain serine 5 residues
intersection_of: GO:0071620 ! phosphorylation of RNA polymerase II C-terminal domain serine 5 residues
intersection_of: part_of GO:0036031 ! recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex
relationship: part_of GO:0036031 ! recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex
created_by: bf
creation_date: 2012-01-11T11:40:41Z

[Term]
id: GO:1900019
name: regulation of protein kinase C activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein kinase C activity." [GOC:signaling, GOC:TermGenie]
synonym: "regulation of PKC" RELATED [GOC:TermGenie]
synonym: "regulation of PKC activity" EXACT [GOC:TermGenie]
is_a: GO:0071900 ! regulation of protein serine/threonine kinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004697 ! protein kinase C activity
relationship: regulates GO:0004697 ! protein kinase C activity
created_by: bf
creation_date: 2012-01-11T03:50:47Z

[Term]
id: GO:1900020
name: positive regulation of protein kinase C activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein kinase C activity." [GOC:signaling, GOC:TermGenie]
synonym: "positive regulation of PKC" RELATED [GOC:TermGenie]
synonym: "positive regulation of PKC activity" EXACT [GOC:TermGenie]
synonym: "up regulation of PKC" RELATED [GOC:TermGenie]
synonym: "up regulation of PKC activity" EXACT [GOC:TermGenie]
is_a: GO:0071902 ! positive regulation of protein serine/threonine kinase activity
is_a: GO:1900019 ! regulation of protein kinase C activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004697 ! protein kinase C activity
relationship: positively_regulates GO:0004697 ! protein kinase C activity
created_by: bf
creation_date: 2012-01-11T03:50:55Z

[Term]
id: GO:1900022
name: regulation of D-erythro-sphingosine kinase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of D-erythro-sphingosine kinase activity." [GOC:signaling, GOC:TermGenie]
synonym: "regulation of sphingosine kinase activity" EXACT [GOC:TermGenie]
is_a: GO:0043549 ! regulation of kinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0017050 ! D-erythro-sphingosine kinase activity
relationship: regulates GO:0017050 ! D-erythro-sphingosine kinase activity
created_by: bf
creation_date: 2012-01-11T04:30:29Z

[Term]
id: GO:1900023
name: positive regulation of D-erythro-sphingosine kinase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of D-erythro-sphingosine kinase activity." [GOC:signaling, GOC:TermGenie]
synonym: "positive regulation of sphingosine kinase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of D-erythro-sphingosine kinase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of sphingosine kinase activity" EXACT [GOC:TermGenie]
is_a: GO:0033674 ! positive regulation of kinase activity
is_a: GO:1900022 ! regulation of D-erythro-sphingosine kinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0017050 ! D-erythro-sphingosine kinase activity
relationship: positively_regulates GO:0017050 ! D-erythro-sphingosine kinase activity
created_by: bf
creation_date: 2012-01-11T04:30:33Z

[Term]
id: GO:1900024
name: regulation of substrate adhesion-dependent cell spreading
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of substrate adhesion-dependent cell spreading." [GOC:TermGenie, GOC:yaf]
synonym: "regulation of cell spreading during cell substrate adhesion" EXACT [GOC:TermGenie]
synonym: "regulation of substrate adhesion dependent cell spreading" EXACT [GOC:TermGenie]
is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation
is_a: GO:0010810 ! regulation of cell-substrate adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034446 ! substrate adhesion-dependent cell spreading
relationship: regulates GO:0034446 ! substrate adhesion-dependent cell spreading
created_by: yaf
creation_date: 2012-01-12T05:00:39Z

[Term]
id: GO:1900025
name: negative regulation of substrate adhesion-dependent cell spreading
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of substrate adhesion-dependent cell spreading." [GOC:TermGenie, GOC:yaf]
synonym: "down regulation of cell spreading during cell substrate adhesion" EXACT [GOC:TermGenie]
synonym: "down regulation of substrate adhesion dependent cell spreading" EXACT [GOC:TermGenie]
synonym: "down regulation of substrate adhesion-dependent cell spreading" RELATED [GOC:TermGenie]
synonym: "negative regulation of cell spreading during cell substrate adhesion" EXACT [GOC:TermGenie]
synonym: "negative regulation of substrate adhesion dependent cell spreading" EXACT [GOC:TermGenie]
is_a: GO:0010771 ! negative regulation of cell morphogenesis involved in differentiation
is_a: GO:0010812 ! negative regulation of cell-substrate adhesion
is_a: GO:1900024 ! regulation of substrate adhesion-dependent cell spreading
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034446 ! substrate adhesion-dependent cell spreading
relationship: negatively_regulates GO:0034446 ! substrate adhesion-dependent cell spreading
created_by: yaf
creation_date: 2012-01-12T05:00:43Z

[Term]
id: GO:1900026
name: positive regulation of substrate adhesion-dependent cell spreading
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of substrate adhesion-dependent cell spreading." [GOC:TermGenie, GOC:yaf]
synonym: "positive regulation of cell spreading during cell substrate adhesion" EXACT [GOC:TermGenie]
synonym: "positive regulation of substrate adhesion dependent cell spreading" EXACT [GOC:TermGenie]
synonym: "up regulation of cell spreading during cell substrate adhesion" EXACT [GOC:TermGenie]
synonym: "up regulation of substrate adhesion dependent cell spreading" EXACT [GOC:TermGenie]
synonym: "up regulation of substrate adhesion-dependent cell spreading" RELATED [GOC:TermGenie]
is_a: GO:0010770 ! positive regulation of cell morphogenesis involved in differentiation
is_a: GO:0010811 ! positive regulation of cell-substrate adhesion
is_a: GO:1900024 ! regulation of substrate adhesion-dependent cell spreading
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034446 ! substrate adhesion-dependent cell spreading
relationship: positively_regulates GO:0034446 ! substrate adhesion-dependent cell spreading
created_by: yaf
creation_date: 2012-01-12T05:00:46Z

[Term]
id: GO:1900027
name: regulation of ruffle assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ruffle assembly." [GOC:TermGenie, GOC:yaf]
synonym: "regulation of membrane ruffle formation" EXACT [GOC:TermGenie]
synonym: "regulation of membrane ruffling" EXACT [GOC:TermGenie]
is_a: GO:0060491 ! regulation of cell projection assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097178 ! ruffle assembly
relationship: regulates GO:0097178 ! ruffle assembly
created_by: yaf
creation_date: 2012-01-12T05:00:49Z

[Term]
id: GO:1900028
name: negative regulation of ruffle assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ruffle assembly." [GOC:TermGenie, GOC:yaf]
synonym: "down regulation of membrane ruffle formation" EXACT [GOC:TermGenie]
synonym: "down regulation of membrane ruffling" EXACT [GOC:TermGenie]
synonym: "down regulation of ruffle assembly" RELATED [GOC:TermGenie]
synonym: "negative regulation of membrane ruffle formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of membrane ruffling" EXACT [GOC:TermGenie]
is_a: GO:0031345 ! negative regulation of cell projection organization
is_a: GO:1900027 ! regulation of ruffle assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097178 ! ruffle assembly
relationship: negatively_regulates GO:0097178 ! ruffle assembly
created_by: yaf
creation_date: 2012-01-12T05:00:53Z

[Term]
id: GO:1900029
name: positive regulation of ruffle assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ruffle assembly." [GOC:TermGenie, GOC:yaf]
synonym: "positive regulation of membrane ruffle formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of membrane ruffling" EXACT [GOC:TermGenie]
synonym: "up regulation of membrane ruffle formation" EXACT [GOC:TermGenie]
synonym: "up regulation of membrane ruffling" EXACT [GOC:TermGenie]
synonym: "up regulation of ruffle assembly" RELATED [GOC:TermGenie]
is_a: GO:0031346 ! positive regulation of cell projection organization
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:1900027 ! regulation of ruffle assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097178 ! ruffle assembly
relationship: positively_regulates GO:0097178 ! ruffle assembly
created_by: yaf
creation_date: 2012-01-12T05:00:56Z

[Term]
id: GO:1900030
name: regulation of pectin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pectin biosynthetic process." [GOC:TermGenie]
synonym: "regulation of pectin anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of pectin biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of pectin formation" EXACT [GOC:TermGenie]
synonym: "regulation of pectin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process
is_a: GO:0032885 ! regulation of polysaccharide biosynthetic process
is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045489 ! pectin biosynthetic process
relationship: regulates GO:0045489 ! pectin biosynthetic process
created_by: tb
creation_date: 2012-01-13T02:03:37Z

[Term]
id: GO:1900031
name: obsolete regulation of transcription from RNA polymerase II promoter involved in calcium-mediated signaling
namespace: biological_process
def: "OBSOLETE. Any regulation of transcription from RNA polymerase II promoter that is involved in calcium-mediated signaling." [GOC:TermGenie, PMID:9407035, PMID:9407036]
comment: This term was made obsolete because regulation of transcription by the signaling pathway is better represented by GO:1900621.
synonym: "global transcription regulation from Pol II promoter of calcium ion signaling" RELATED [GOC:TermGenie]
synonym: "global transcription regulation from Pol II promoter of calcium signaling" RELATED [GOC:TermGenie]
synonym: "global transcription regulation from Pol II promoter of calcium signalling" RELATED [GOC:TermGenie]
synonym: "global transcription regulation from Pol II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "global transcription regulation from Pol II promoter of calcium-mediated signalling" RELATED [GOC:TermGenie]
synonym: "regulation of gene-specific transcription from RNA polymerase II promoter of calcium ion signaling" RELATED [GOC:TermGenie]
synonym: "regulation of gene-specific transcription from RNA polymerase II promoter of calcium signaling" RELATED [GOC:TermGenie]
synonym: "regulation of gene-specific transcription from RNA polymerase II promoter of calcium signalling" RELATED [GOC:TermGenie]
synonym: "regulation of gene-specific transcription from RNA polymerase II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "regulation of gene-specific transcription from RNA polymerase II promoter of calcium-mediated signalling" RELATED [GOC:TermGenie]
synonym: "regulation of global transcription from Pol II promoter of calcium ion signaling" RELATED [GOC:TermGenie]
synonym: "regulation of global transcription from Pol II promoter of calcium signaling" RELATED [GOC:TermGenie]
synonym: "regulation of global transcription from Pol II promoter of calcium signalling" RELATED [GOC:TermGenie]
synonym: "regulation of global transcription from Pol II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "regulation of global transcription from Pol II promoter of calcium-mediated signalling" RELATED [GOC:TermGenie]
synonym: "regulation of transcription from Pol II promoter of calcium ion signaling" EXACT [GOC:TermGenie]
synonym: "regulation of transcription from Pol II promoter of calcium signaling" EXACT [GOC:TermGenie]
synonym: "regulation of transcription from Pol II promoter of calcium signalling" EXACT [GOC:TermGenie]
synonym: "regulation of transcription from Pol II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "regulation of transcription from Pol II promoter of calcium-mediated signalling" EXACT [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter involved in calcium-mediated signaling" EXACT []
synonym: "regulation of transcription from RNA polymerase II promoter of calcium ion signaling" RELATED [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter of calcium signaling" RELATED [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter of calcium signalling" RELATED [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter of calcium-mediated signalling" RELATED [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter, global of calcium ion signaling" RELATED [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter, global of calcium signaling" RELATED [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter, global of calcium signalling" RELATED [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter, global of calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter, global of calcium-mediated signalling" RELATED [GOC:TermGenie]
is_obsolete: true
replaced_by: GO:1900621
created_by: krc
creation_date: 2012-01-13T04:09:19Z

[Term]
id: GO:1900032
name: regulation of trichome patterning
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of trichome patterning." [GOC:TermGenie]
synonym: "regulation of trichome distribution" BROAD [GOC:TermGenie]
synonym: "regulation of trichome pattern biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of trichome pattern formation" EXACT [GOC:TermGenie]
synonym: "regulation of trichome pattern specification" RELATED [GOC:TermGenie]
synonym: "regulation of trichome spacing" EXACT [GOC:TermGenie]
is_a: GO:0010453 ! regulation of cell fate commitment
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0023051 ! regulation of signaling
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048629 ! trichome patterning
relationship: regulates GO:0048629 ! trichome patterning
created_by: tb
creation_date: 2012-01-13T11:10:46Z

[Term]
id: GO:1900033
name: negative regulation of trichome patterning
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of trichome patterning." [GOC:TermGenie]
synonym: "down regulation of trichome distribution" BROAD [GOC:TermGenie]
synonym: "down regulation of trichome pattern biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of trichome pattern formation" EXACT [GOC:TermGenie]
synonym: "down regulation of trichome pattern specification" RELATED [GOC:TermGenie]
synonym: "down regulation of trichome patterning" RELATED [GOC:TermGenie]
synonym: "down regulation of trichome spacing" EXACT [GOC:TermGenie]
synonym: "down-regulation of trichome distribution" BROAD [GOC:TermGenie]
synonym: "down-regulation of trichome pattern biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of trichome pattern formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of trichome pattern specification" RELATED [GOC:TermGenie]
synonym: "down-regulation of trichome patterning" RELATED [GOC:TermGenie]
synonym: "down-regulation of trichome spacing" EXACT [GOC:TermGenie]
synonym: "downregulation of trichome distribution" BROAD [GOC:TermGenie]
synonym: "downregulation of trichome pattern biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of trichome pattern formation" EXACT [GOC:TermGenie]
synonym: "downregulation of trichome pattern specification" RELATED [GOC:TermGenie]
synonym: "downregulation of trichome patterning" RELATED [GOC:TermGenie]
synonym: "downregulation of trichome spacing" EXACT [GOC:TermGenie]
synonym: "inhibition of trichome distribution" BROAD [GOC:TermGenie]
synonym: "inhibition of trichome pattern biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of trichome pattern formation" EXACT [GOC:TermGenie]
synonym: "inhibition of trichome pattern specification" RELATED [GOC:TermGenie]
synonym: "inhibition of trichome patterning" RELATED [GOC:TermGenie]
synonym: "inhibition of trichome spacing" EXACT [GOC:TermGenie]
synonym: "negative regulation of trichome distribution" BROAD [GOC:TermGenie]
synonym: "negative regulation of trichome pattern biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of trichome pattern formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of trichome pattern specification" RELATED [GOC:TermGenie]
synonym: "negative regulation of trichome spacing" EXACT [GOC:TermGenie]
is_a: GO:0010454 ! negative regulation of cell fate commitment
is_a: GO:0010648 ! negative regulation of cell communication
is_a: GO:0023057 ! negative regulation of signaling
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1900032 ! regulation of trichome patterning
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048629 ! trichome patterning
relationship: negatively_regulates GO:0048629 ! trichome patterning
created_by: tb
creation_date: 2012-01-13T11:10:50Z

[Term]
id: GO:1900034
name: regulation of cellular response to heat
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular response to heat." [GOC:TermGenie, GOC:yaf]
synonym: "regulation of cellular response to heat stress" EXACT [GOC:TermGenie]
is_a: GO:0080135 ! regulation of cellular response to stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034605 ! cellular response to heat
relationship: regulates GO:0034605 ! cellular response to heat
created_by: yaf
creation_date: 2012-01-17T09:27:40Z

[Term]
id: GO:1900035
name: negative regulation of cellular response to heat
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to heat." [GOC:TermGenie, GOC:yaf]
synonym: "down regulation of cellular response to heat" RELATED [GOC:TermGenie]
synonym: "down regulation of cellular response to heat stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular response to heat" RELATED [GOC:TermGenie]
synonym: "down-regulation of cellular response to heat stress" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular response to heat" RELATED [GOC:TermGenie]
synonym: "downregulation of cellular response to heat stress" EXACT [GOC:TermGenie]
synonym: "inhibition of cellular response to heat" RELATED [GOC:TermGenie]
synonym: "inhibition of cellular response to heat stress" EXACT [GOC:TermGenie]
synonym: "negative regulation of cellular response to heat stress" EXACT [GOC:TermGenie]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1900034 ! regulation of cellular response to heat
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034605 ! cellular response to heat
relationship: negatively_regulates GO:0034605 ! cellular response to heat
created_by: yaf
creation_date: 2012-01-17T09:27:44Z

[Term]
id: GO:1900036
name: positive regulation of cellular response to heat
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellular response to heat." [GOC:TermGenie, GOC:yaf]
synonym: "activation of cellular response to heat" RELATED [GOC:TermGenie]
synonym: "activation of cellular response to heat stress" EXACT [GOC:TermGenie]
synonym: "positive regulation of cellular response to heat stress" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular response to heat" RELATED [GOC:TermGenie]
synonym: "up regulation of cellular response to heat stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular response to heat" RELATED [GOC:TermGenie]
synonym: "up-regulation of cellular response to heat stress" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular response to heat" RELATED [GOC:TermGenie]
synonym: "upregulation of cellular response to heat stress" EXACT [GOC:TermGenie]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1900034 ! regulation of cellular response to heat
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034605 ! cellular response to heat
relationship: positively_regulates GO:0034605 ! cellular response to heat
created_by: yaf
creation_date: 2012-01-17T09:27:47Z

[Term]
id: GO:1900037
name: regulation of cellular response to hypoxia
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular response to hypoxia." [GOC:TermGenie, GOC:yaf]
synonym: "regulation of cellular response to hypoxic stress" EXACT [GOC:TermGenie]
synonym: "regulation of cellular response to lowered oxygen tension" EXACT [GOC:TermGenie]
is_a: GO:0080135 ! regulation of cellular response to stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071456 ! cellular response to hypoxia
relationship: regulates GO:0071456 ! cellular response to hypoxia
created_by: yaf
creation_date: 2012-01-17T09:29:03Z

[Term]
id: GO:1900038
name: negative regulation of cellular response to hypoxia
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to hypoxia." [GOC:TermGenie, GOC:yaf]
synonym: "down regulation of cellular response to hypoxia" RELATED [GOC:TermGenie]
synonym: "down regulation of cellular response to hypoxic stress" EXACT [GOC:TermGenie]
synonym: "down regulation of cellular response to lowered oxygen tension" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular response to hypoxia" RELATED [GOC:TermGenie]
synonym: "down-regulation of cellular response to hypoxic stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular response to lowered oxygen tension" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular response to hypoxia" RELATED [GOC:TermGenie]
synonym: "downregulation of cellular response to hypoxic stress" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular response to lowered oxygen tension" EXACT [GOC:TermGenie]
synonym: "inhibition of cellular response to hypoxia" RELATED [GOC:TermGenie]
synonym: "inhibition of cellular response to hypoxic stress" EXACT [GOC:TermGenie]
synonym: "inhibition of cellular response to lowered oxygen tension" EXACT [GOC:TermGenie]
synonym: "negative regulation of cellular response to hypoxic stress" EXACT [GOC:TermGenie]
synonym: "negative regulation of cellular response to lowered oxygen tension" EXACT [GOC:TermGenie]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1900037 ! regulation of cellular response to hypoxia
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071456 ! cellular response to hypoxia
relationship: negatively_regulates GO:0071456 ! cellular response to hypoxia
created_by: yaf
creation_date: 2012-01-17T09:29:16Z

[Term]
id: GO:1900039
name: positive regulation of cellular response to hypoxia
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellular response to hypoxia." [GOC:TermGenie, GOC:yaf]
synonym: "activation of cellular response to hypoxia" RELATED [GOC:TermGenie]
synonym: "activation of cellular response to hypoxic stress" EXACT [GOC:TermGenie]
synonym: "activation of cellular response to lowered oxygen tension" EXACT [GOC:TermGenie]
synonym: "positive regulation of cellular response to hypoxic stress" EXACT [GOC:TermGenie]
synonym: "positive regulation of cellular response to lowered oxygen tension" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular response to hypoxia" RELATED [GOC:TermGenie]
synonym: "up regulation of cellular response to hypoxic stress" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular response to lowered oxygen tension" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular response to hypoxia" RELATED [GOC:TermGenie]
synonym: "up-regulation of cellular response to hypoxic stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular response to lowered oxygen tension" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular response to hypoxia" RELATED [GOC:TermGenie]
synonym: "upregulation of cellular response to hypoxic stress" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular response to lowered oxygen tension" EXACT [GOC:TermGenie]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1900037 ! regulation of cellular response to hypoxia
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071456 ! cellular response to hypoxia
relationship: positively_regulates GO:0071456 ! cellular response to hypoxia
created_by: yaf
creation_date: 2012-01-17T09:29:19Z

[Term]
id: GO:1900040
name: regulation of interleukin-2 secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of interleukin-2 secretion." [GOC:TermGenie, GOC:yaf]
synonym: "regulation of IL-2 secretion" EXACT [GOC:TermGenie]
is_a: GO:0032663 ! regulation of interleukin-2 production
is_a: GO:0050707 ! regulation of cytokine secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070970 ! interleukin-2 secretion
relationship: regulates GO:0070970 ! interleukin-2 secretion
created_by: yaf
creation_date: 2012-01-17T11:20:57Z

[Term]
id: GO:1900041
name: negative regulation of interleukin-2 secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-2 secretion." [GOC:TermGenie, GOC:yaf]
synonym: "down regulation of IL-2 secretion" EXACT [GOC:TermGenie]
synonym: "down regulation of interleukin-2 secretion" RELATED [GOC:TermGenie]
synonym: "down-regulation of IL-2 secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of interleukin-2 secretion" RELATED [GOC:TermGenie]
synonym: "downregulation of IL-2 secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of interleukin-2 secretion" RELATED [GOC:TermGenie]
synonym: "inhibition of IL-2 secretion" EXACT [GOC:TermGenie]
synonym: "inhibition of interleukin-2 secretion" RELATED [GOC:TermGenie]
synonym: "negative regulation of IL-2 secretion" EXACT [GOC:TermGenie]
is_a: GO:0032703 ! negative regulation of interleukin-2 production
is_a: GO:0050710 ! negative regulation of cytokine secretion
is_a: GO:1900040 ! regulation of interleukin-2 secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070970 ! interleukin-2 secretion
relationship: negatively_regulates GO:0070970 ! interleukin-2 secretion
created_by: yaf
creation_date: 2012-01-17T11:21:06Z

[Term]
id: GO:1900042
name: positive regulation of interleukin-2 secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of interleukin-2 secretion." [GOC:TermGenie, GOC:yaf]
synonym: "activation of IL-2 secretion" EXACT [GOC:TermGenie]
synonym: "activation of interleukin-2 secretion" RELATED [GOC:TermGenie]
synonym: "positive regulation of IL-2 secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of IL-2 secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of interleukin-2 secretion" RELATED [GOC:TermGenie]
synonym: "up-regulation of IL-2 secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of interleukin-2 secretion" RELATED [GOC:TermGenie]
synonym: "upregulation of IL-2 secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of interleukin-2 secretion" RELATED [GOC:TermGenie]
is_a: GO:0032743 ! positive regulation of interleukin-2 production
is_a: GO:0050715 ! positive regulation of cytokine secretion
is_a: GO:1900040 ! regulation of interleukin-2 secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070970 ! interleukin-2 secretion
relationship: positively_regulates GO:0070970 ! interleukin-2 secretion
created_by: yaf
creation_date: 2012-01-17T11:21:10Z

[Term]
id: GO:1900043
name: obsolete leptin-mediated signaling pathway involved in negative regulation of appetite
namespace: biological_process
def: "OBSOLETE. Any leptin-mediated signaling pathway that is involved in negative regulation of appetite." [GOC:BHF, GOC:TermGenie]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "adipocytokine signaling pathway of appetite suppression" RELATED [GOC:TermGenie]
synonym: "adipocytokine signaling pathway of down regulation of appetite" RELATED [GOC:TermGenie]
synonym: "adipocytokine signaling pathway of down-regulation of appetite" RELATED [GOC:TermGenie]
synonym: "adipocytokine signaling pathway of downregulation of appetite" RELATED [GOC:TermGenie]
synonym: "adipocytokine signaling pathway of inhibition of appetite" RELATED [GOC:TermGenie]
synonym: "adipocytokine signaling pathway of negative regulation of appetite" RELATED [GOC:TermGenie]
synonym: "adipocytokine signaling pathway of negative regulation of hunger" RELATED [GOC:TermGenie]
synonym: "leptin-mediated signaling pathway involved in negative regulation of appetite" EXACT []
synonym: "leptin-mediated signaling pathway of appetite suppression" RELATED [GOC:TermGenie]
synonym: "leptin-mediated signaling pathway of down regulation of appetite" RELATED [GOC:TermGenie]
synonym: "leptin-mediated signaling pathway of down-regulation of appetite" RELATED [GOC:TermGenie]
synonym: "leptin-mediated signaling pathway of downregulation of appetite" RELATED [GOC:TermGenie]
synonym: "leptin-mediated signaling pathway of inhibition of appetite" RELATED [GOC:TermGenie]
synonym: "leptin-mediated signaling pathway of negative regulation of appetite" RELATED [GOC:TermGenie]
synonym: "leptin-mediated signaling pathway of negative regulation of hunger" RELATED [GOC:TermGenie]
synonym: "leptin-mediated signalling pathway of appetite suppression" RELATED [GOC:TermGenie]
synonym: "leptin-mediated signalling pathway of down regulation of appetite" EXACT [GOC:TermGenie]
synonym: "leptin-mediated signalling pathway of down-regulation of appetite" EXACT [GOC:TermGenie]
synonym: "leptin-mediated signalling pathway of downregulation of appetite" EXACT [GOC:TermGenie]
synonym: "leptin-mediated signalling pathway of inhibition of appetite" NARROW [GOC:TermGenie]
synonym: "leptin-mediated signalling pathway of negative regulation of appetite" RELATED [GOC:TermGenie]
synonym: "leptin-mediated signalling pathway of negative regulation of hunger" RELATED [GOC:TermGenie]
is_obsolete: true
created_by: vk
creation_date: 2012-01-19T11:10:22Z

[Term]
id: GO:1900044
name: regulation of protein K63-linked ubiquitination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein K63-linked ubiquitination." [GOC:TermGenie]
synonym: "regulation of protein K63-linked polyubiquitination" EXACT [GOC:TermGenie]
is_a: GO:1902914 ! regulation of protein polyubiquitination
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070534 ! protein K63-linked ubiquitination
relationship: regulates GO:0070534 ! protein K63-linked ubiquitination
created_by: bf
creation_date: 2012-01-19T11:44:37Z

[Term]
id: GO:1900045
name: negative regulation of protein K63-linked ubiquitination
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein K63-linked ubiquitination." [GOC:TermGenie]
synonym: "down regulation of protein K63-linked polyubiquitination" EXACT [GOC:TermGenie]
synonym: "down regulation of protein K63-linked ubiquitination" RELATED [GOC:TermGenie]
synonym: "down-regulation of protein K63-linked polyubiquitination" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein K63-linked ubiquitination" RELATED [GOC:TermGenie]
synonym: "downregulation of protein K63-linked polyubiquitination" EXACT [GOC:TermGenie]
synonym: "downregulation of protein K63-linked ubiquitination" RELATED [GOC:TermGenie]
synonym: "inhibition of protein K63-linked polyubiquitination" EXACT [GOC:TermGenie]
synonym: "inhibition of protein K63-linked ubiquitination" RELATED [GOC:TermGenie]
synonym: "negative regulation of protein K63-linked polyubiquitination" EXACT [GOC:TermGenie]
is_a: GO:1900044 ! regulation of protein K63-linked ubiquitination
is_a: GO:1902915 ! negative regulation of protein polyubiquitination
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070534 ! protein K63-linked ubiquitination
relationship: negatively_regulates GO:0070534 ! protein K63-linked ubiquitination
created_by: bf
creation_date: 2012-01-19T11:44:41Z

[Term]
id: GO:1900046
name: regulation of hemostasis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hemostasis." [GOC:TermGenie]
is_a: GO:0050878 ! regulation of body fluid levels
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007599 ! hemostasis
relationship: regulates GO:0007599 ! hemostasis
created_by: jl
creation_date: 2012-01-19T03:23:38Z

[Term]
id: GO:1900047
name: negative regulation of hemostasis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hemostasis." [GOC:TermGenie]
synonym: "down regulation of hemostasis" EXACT [GOC:TermGenie]
synonym: "down-regulation of hemostasis" EXACT [GOC:TermGenie]
synonym: "downregulation of hemostasis" EXACT [GOC:TermGenie]
synonym: "inhibition of hemostasis" NARROW [GOC:TermGenie]
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1900046 ! regulation of hemostasis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007599 ! hemostasis
relationship: negatively_regulates GO:0007599 ! hemostasis
created_by: jl
creation_date: 2012-01-19T03:23:42Z

[Term]
id: GO:1900048
name: positive regulation of hemostasis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hemostasis." [GOC:TermGenie]
synonym: "activation of hemostasis" NARROW [GOC:TermGenie]
synonym: "up regulation of hemostasis" EXACT [GOC:TermGenie]
synonym: "up-regulation of hemostasis" EXACT [GOC:TermGenie]
synonym: "upregulation of hemostasis" EXACT [GOC:TermGenie]
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1900046 ! regulation of hemostasis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007599 ! hemostasis
relationship: positively_regulates GO:0007599 ! hemostasis
created_by: jl
creation_date: 2012-01-19T03:23:45Z

[Term]
id: GO:1900049
name: regulation of histone exchange
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of histone exchange." [GOC:TermGenie, PMID:20332092]
synonym: "regulation of histone chaperone" RELATED [GOC:TermGenie]
synonym: "regulation of histone displacement" EXACT [GOC:TermGenie]
synonym: "regulation of histone replacement" EXACT [GOC:TermGenie]
is_a: GO:1903308 ! regulation of chromatin modification
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043486 ! histone exchange
relationship: regulates GO:0043486 ! histone exchange
created_by: se
creation_date: 2012-01-19T10:59:02Z

[Term]
id: GO:1900050
name: negative regulation of histone exchange
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone exchange." [GOC:TermGenie, PMID:20332092]
synonym: "down regulation of histone chaperone" RELATED [GOC:TermGenie]
synonym: "down regulation of histone exchange" RELATED [GOC:TermGenie]
synonym: "down regulation of histone replacement" EXACT [GOC:TermGenie]
synonym: "down-regulation of histone chaperone" RELATED [GOC:TermGenie]
synonym: "down-regulation of histone exchange" RELATED [GOC:TermGenie]
synonym: "down-regulation of histone replacement" EXACT [GOC:TermGenie]
synonym: "downregulation of histone chaperone" RELATED [GOC:TermGenie]
synonym: "downregulation of histone exchange" RELATED [GOC:TermGenie]
synonym: "downregulation of histone replacement" EXACT [GOC:TermGenie]
synonym: "inhibition of histone chaperone" RELATED [GOC:TermGenie]
synonym: "inhibition of histone exchange" RELATED [GOC:TermGenie]
synonym: "inhibition of histone replacement" EXACT [GOC:TermGenie]
synonym: "negative regulation of histone chaperone" RELATED [GOC:TermGenie]
synonym: "negative regulation of histone replacement" EXACT [GOC:TermGenie]
is_a: GO:1900049 ! regulation of histone exchange
is_a: GO:1903309 ! negative regulation of chromatin modification
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043486 ! histone exchange
relationship: negatively_regulates GO:0043486 ! histone exchange
created_by: se
creation_date: 2012-01-19T10:59:09Z

[Term]
id: GO:1900051
name: positive regulation of histone exchange
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of histone exchange." [GOC:TermGenie, PMID:20332092]
synonym: "activation of histone chaperone" RELATED [GOC:TermGenie]
synonym: "activation of histone exchange" RELATED [GOC:TermGenie]
synonym: "activation of histone replacement" EXACT [GOC:TermGenie]
synonym: "positive regulation of histone chaperone" RELATED [GOC:TermGenie]
synonym: "positive regulation of histone replacement" EXACT [GOC:TermGenie]
synonym: "up regulation of histone chaperone" RELATED [GOC:TermGenie]
synonym: "up regulation of histone exchange" RELATED [GOC:TermGenie]
synonym: "up regulation of histone replacement" EXACT [GOC:TermGenie]
synonym: "up-regulation of histone chaperone" RELATED [GOC:TermGenie]
synonym: "up-regulation of histone exchange" RELATED [GOC:TermGenie]
synonym: "up-regulation of histone replacement" EXACT [GOC:TermGenie]
synonym: "upregulation of histone chaperone" RELATED [GOC:TermGenie]
synonym: "upregulation of histone exchange" RELATED [GOC:TermGenie]
synonym: "upregulation of histone replacement" EXACT [GOC:TermGenie]
is_a: GO:1900049 ! regulation of histone exchange
is_a: GO:1903310 ! positive regulation of chromatin modification
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043486 ! histone exchange
relationship: positively_regulates GO:0043486 ! histone exchange
created_by: se
creation_date: 2012-01-19T10:59:12Z

[Term]
id: GO:1900052
name: regulation of retinoic acid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of retinoic acid biosynthetic process." [GOC:TermGenie, GOC:yaf]
synonym: "regulation of retinoic acid anabolic process" EXACT [GOC:TermGenie]
is_a: GO:0010565 ! regulation of cellular ketone metabolic process
is_a: GO:0019747 ! regulation of isoprenoid metabolic process
is_a: GO:0030656 ! regulation of vitamin metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0032350 ! regulation of hormone metabolic process
is_a: GO:0046890 ! regulation of lipid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002138 ! retinoic acid biosynthetic process
relationship: regulates GO:0002138 ! retinoic acid biosynthetic process
created_by: yaf
creation_date: 2012-01-20T09:55:45Z

[Term]
id: GO:1900053
name: negative regulation of retinoic acid biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of retinoic acid biosynthetic process." [GOC:TermGenie, GOC:yaf]
synonym: "down regulation of retinoic acid anabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of retinoic acid biosynthetic process" RELATED [GOC:TermGenie]
synonym: "down-regulation of retinoic acid anabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of retinoic acid biosynthetic process" RELATED [GOC:TermGenie]
synonym: "downregulation of retinoic acid anabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of retinoic acid biosynthetic process" RELATED [GOC:TermGenie]
synonym: "inhibition of retinoic acid anabolic process" EXACT [GOC:TermGenie]
synonym: "inhibition of retinoic acid biosynthetic process" RELATED [GOC:TermGenie]
synonym: "negative regulation of retinoic acid anabolic process" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0032351 ! negative regulation of hormone metabolic process
is_a: GO:0045827 ! negative regulation of isoprenoid metabolic process
is_a: GO:0046137 ! negative regulation of vitamin metabolic process
is_a: GO:0051055 ! negative regulation of lipid biosynthetic process
is_a: GO:1900052 ! regulation of retinoic acid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002138 ! retinoic acid biosynthetic process
relationship: negatively_regulates GO:0002138 ! retinoic acid biosynthetic process
created_by: yaf
creation_date: 2012-01-20T09:55:49Z

[Term]
id: GO:1900054
name: positive regulation of retinoic acid biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of retinoic acid biosynthetic process." [GOC:TermGenie, GOC:yaf]
synonym: "activation of retinoic acid anabolic process" EXACT [GOC:TermGenie]
synonym: "activation of retinoic acid biosynthetic process" RELATED [GOC:TermGenie]
synonym: "positive regulation of retinoic acid anabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of retinoic acid anabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of retinoic acid biosynthetic process" RELATED [GOC:TermGenie]
synonym: "up-regulation of retinoic acid anabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of retinoic acid biosynthetic process" RELATED [GOC:TermGenie]
synonym: "upregulation of retinoic acid anabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of retinoic acid biosynthetic process" RELATED [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0032352 ! positive regulation of hormone metabolic process
is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process
is_a: GO:0046136 ! positive regulation of vitamin metabolic process
is_a: GO:0046889 ! positive regulation of lipid biosynthetic process
is_a: GO:1900052 ! regulation of retinoic acid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002138 ! retinoic acid biosynthetic process
relationship: positively_regulates GO:0002138 ! retinoic acid biosynthetic process
created_by: yaf
creation_date: 2012-01-20T09:55:52Z

[Term]
id: GO:1900055
name: regulation of leaf senescence
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of leaf senescence." [GOC:TermGenie]
is_a: GO:2000024 ! regulation of leaf development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010150 ! leaf senescence
relationship: regulates GO:0010150 ! leaf senescence
created_by: tb
creation_date: 2012-01-24T11:51:24Z

[Term]
id: GO:1900056
name: negative regulation of leaf senescence
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of leaf senescence." [GOC:TermGenie]
synonym: "down regulation of leaf senescence" RELATED [GOC:TermGenie]
synonym: "down-regulation of leaf senescence" RELATED [GOC:TermGenie]
synonym: "downregulation of leaf senescence" RELATED [GOC:TermGenie]
synonym: "inhibition of leaf senescence" RELATED [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1900055 ! regulation of leaf senescence
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010150 ! leaf senescence
relationship: negatively_regulates GO:0010150 ! leaf senescence
created_by: tb
creation_date: 2012-01-24T11:51:32Z

[Term]
id: GO:1900057
name: positive regulation of leaf senescence
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of leaf senescence." [GOC:TermGenie]
synonym: "activation of leaf senescence" RELATED [GOC:TermGenie]
synonym: "up regulation of leaf senescence" RELATED [GOC:TermGenie]
synonym: "up-regulation of leaf senescence" RELATED [GOC:TermGenie]
synonym: "upregulation of leaf senescence" RELATED [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1900055 ! regulation of leaf senescence
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010150 ! leaf senescence
relationship: positively_regulates GO:0010150 ! leaf senescence
created_by: tb
creation_date: 2012-01-24T11:51:36Z

[Term]
id: GO:1900058
name: regulation of sulfate assimilation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sulfate assimilation." [GOC:TermGenie, PMID:7601277, PMID:7891681]
synonym: "regulation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor" NARROW [GOC:TermGenie]
synonym: "regulation of sulphate assimilation" EXACT [GOC:TermGenie]
synonym: "regulation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor" NARROW [GOC:TermGenie]
is_a: GO:0042762 ! regulation of sulfur metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000103 ! sulfate assimilation
relationship: regulates GO:0000103 ! sulfate assimilation
created_by: dph
creation_date: 2012-01-25T03:14:40Z

[Term]
id: GO:1900059
name: positive regulation of sulfate assimilation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sulfate assimilation." [GOC:TermGenie, PMID:7601277, PMID:7891681]
synonym: "activation of sulfate assimilation" RELATED [GOC:TermGenie]
synonym: "activation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor" NARROW [GOC:TermGenie]
synonym: "activation of sulphate assimilation" EXACT [GOC:TermGenie]
synonym: "activation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor" NARROW [GOC:TermGenie]
synonym: "positive regulation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor" NARROW [GOC:TermGenie]
synonym: "positive regulation of sulphate assimilation" EXACT [GOC:TermGenie]
synonym: "positive regulation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor" NARROW [GOC:TermGenie]
synonym: "up regulation of sulfate assimilation" RELATED [GOC:TermGenie]
synonym: "up regulation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor" NARROW [GOC:TermGenie]
synonym: "up regulation of sulphate assimilation" EXACT [GOC:TermGenie]
synonym: "up regulation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor" NARROW [GOC:TermGenie]
synonym: "up-regulation of sulfate assimilation" RELATED [GOC:TermGenie]
synonym: "up-regulation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor" NARROW [GOC:TermGenie]
synonym: "up-regulation of sulphate assimilation" EXACT [GOC:TermGenie]
synonym: "up-regulation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor" NARROW [GOC:TermGenie]
synonym: "upregulation of sulfate assimilation" RELATED [GOC:TermGenie]
synonym: "upregulation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor" NARROW [GOC:TermGenie]
synonym: "upregulation of sulphate assimilation" EXACT [GOC:TermGenie]
synonym: "upregulation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor" NARROW [GOC:TermGenie]
is_a: GO:0051176 ! positive regulation of sulfur metabolic process
is_a: GO:1900058 ! regulation of sulfate assimilation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000103 ! sulfate assimilation
relationship: positively_regulates GO:0000103 ! sulfate assimilation
created_by: dph
creation_date: 2012-01-25T03:14:47Z

[Term]
id: GO:1900060
name: negative regulation of ceramide biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of a ceramide biosynthetic process." [GOC:TermGenie, PMID:15302821]
synonym: "down regulation of ceramide anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of ceramide biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of ceramide biosynthetic process" RELATED [GOC:TermGenie]
synonym: "down regulation of ceramide formation" EXACT [GOC:TermGenie]
synonym: "down regulation of ceramide synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of ceramide anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of ceramide biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of ceramide biosynthetic process" RELATED [GOC:TermGenie]
synonym: "down-regulation of ceramide formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of ceramide synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of ceramide anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of ceramide biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of ceramide biosynthetic process" RELATED [GOC:TermGenie]
synonym: "downregulation of ceramide formation" EXACT [GOC:TermGenie]
synonym: "downregulation of ceramide synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of ceramide anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of ceramide biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of ceramide biosynthetic process" RELATED [GOC:TermGenie]
synonym: "inhibition of ceramide formation" EXACT [GOC:TermGenie]
synonym: "inhibition of ceramide synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of ceramide anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of ceramide biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of ceramide formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of ceramide synthesis" EXACT [GOC:TermGenie]
is_a: GO:0034249 ! negative regulation of cellular amide metabolic process
is_a: GO:0090155 ! negative regulation of sphingolipid biosynthetic process
is_a: GO:2000303 ! regulation of ceramide biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0046513 ! ceramide biosynthetic process
relationship: negatively_regulates GO:0046513 ! ceramide biosynthetic process
created_by: dph
creation_date: 2012-01-25T03:18:07Z

[Term]
id: GO:1900061
name: obsolete positive regulation of transcription from RNA polymerase II promoter involved in calcium-mediated signaling
namespace: biological_process
def: "OBSOLETE. Any positive regulation of transcription from RNA polymerase II promoter that is involved in calcium-mediated signaling." [GOC:TermGenie, PMID:9407035, PMID:9407036]
comment: This term was made obsolete because activation of transcription by the signaling pathway is better represented by GO:1900622.
synonym: "activation of global transcription from RNA polymerase II promoter of calcium ion signaling" RELATED [GOC:TermGenie]
synonym: "activation of global transcription from RNA polymerase II promoter of calcium signaling" RELATED [GOC:TermGenie]
synonym: "activation of global transcription from RNA polymerase II promoter of calcium signalling" RELATED [GOC:TermGenie]
synonym: "activation of global transcription from RNA polymerase II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "activation of global transcription from RNA polymerase II promoter of calcium-mediated signalling" RELATED [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase II promoter of calcium ion signaling" NARROW [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase II promoter of calcium signaling" NARROW [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase II promoter of calcium signalling" NARROW [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase II promoter of calcium-mediated signaling" NARROW [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase II promoter of calcium-mediated signalling" NARROW [GOC:TermGenie]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter of calcium ion signaling" RELATED [GOC:TermGenie]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter of calcium signaling" RELATED [GOC:TermGenie]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter of calcium signalling" RELATED [GOC:TermGenie]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter of calcium-mediated signalling" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription from Pol II promoter of calcium ion signaling" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription from Pol II promoter of calcium signaling" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription from Pol II promoter of calcium signalling" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription from Pol II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription from Pol II promoter of calcium-mediated signalling" RELATED [GOC:TermGenie]
synonym: "positive regulation of transcription from Pol II promoter of calcium ion signaling" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription from Pol II promoter of calcium signaling" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription from Pol II promoter of calcium signalling" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription from Pol II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "positive regulation of transcription from Pol II promoter of calcium-mediated signalling" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription from RNA polymerase II promoter involved in calcium-mediated signaling" EXACT []
synonym: "positive regulation of transcription from RNA polymerase II promoter of calcium ion signaling" RELATED [GOC:TermGenie]
synonym: "positive regulation of transcription from RNA polymerase II promoter of calcium signaling" RELATED [GOC:TermGenie]
synonym: "positive regulation of transcription from RNA polymerase II promoter of calcium signalling" RELATED [GOC:TermGenie]
synonym: "positive regulation of transcription from RNA polymerase II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "positive regulation of transcription from RNA polymerase II promoter of calcium-mediated signalling" RELATED [GOC:TermGenie]
synonym: "stimulation of global transcription from RNA polymerase II promoter of calcium ion signaling" NARROW [GOC:TermGenie]
synonym: "stimulation of global transcription from RNA polymerase II promoter of calcium signaling" NARROW [GOC:TermGenie]
synonym: "stimulation of global transcription from RNA polymerase II promoter of calcium signalling" NARROW [GOC:TermGenie]
synonym: "stimulation of global transcription from RNA polymerase II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "stimulation of global transcription from RNA polymerase II promoter of calcium-mediated signalling" NARROW [GOC:TermGenie]
synonym: "stimulation of transcription from RNA polymerase II promoter of calcium ion signaling" EXACT [GOC:TermGenie]
synonym: "stimulation of transcription from RNA polymerase II promoter of calcium signaling" EXACT [GOC:TermGenie]
synonym: "stimulation of transcription from RNA polymerase II promoter of calcium signalling" EXACT [GOC:TermGenie]
synonym: "stimulation of transcription from RNA polymerase II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "stimulation of transcription from RNA polymerase II promoter of calcium-mediated signalling" EXACT [GOC:TermGenie]
synonym: "up regulation of global transcription from RNA polymerase II promoter of calcium ion signaling" RELATED [GOC:TermGenie]
synonym: "up regulation of global transcription from RNA polymerase II promoter of calcium signaling" RELATED [GOC:TermGenie]
synonym: "up regulation of global transcription from RNA polymerase II promoter of calcium signalling" RELATED [GOC:TermGenie]
synonym: "up regulation of global transcription from RNA polymerase II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "up regulation of global transcription from RNA polymerase II promoter of calcium-mediated signalling" RELATED [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase II promoter of calcium ion signaling" EXACT [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase II promoter of calcium signaling" EXACT [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase II promoter of calcium signalling" EXACT [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase II promoter of calcium-mediated signalling" EXACT [GOC:TermGenie]
synonym: "up-regulation of global transcription from RNA polymerase II promoter of calcium ion signaling" RELATED [GOC:TermGenie]
synonym: "up-regulation of global transcription from RNA polymerase II promoter of calcium signaling" RELATED [GOC:TermGenie]
synonym: "up-regulation of global transcription from RNA polymerase II promoter of calcium signalling" RELATED [GOC:TermGenie]
synonym: "up-regulation of global transcription from RNA polymerase II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "up-regulation of global transcription from RNA polymerase II promoter of calcium-mediated signalling" RELATED [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase II promoter of calcium ion signaling" EXACT [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase II promoter of calcium signaling" EXACT [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase II promoter of calcium signalling" EXACT [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase II promoter of calcium-mediated signalling" EXACT [GOC:TermGenie]
synonym: "upregulation of global transcription from RNA polymerase II promoter of calcium ion signaling" RELATED [GOC:TermGenie]
synonym: "upregulation of global transcription from RNA polymerase II promoter of calcium signaling" RELATED [GOC:TermGenie]
synonym: "upregulation of global transcription from RNA polymerase II promoter of calcium signalling" RELATED [GOC:TermGenie]
synonym: "upregulation of global transcription from RNA polymerase II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "upregulation of global transcription from RNA polymerase II promoter of calcium-mediated signalling" RELATED [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase II promoter of calcium ion signaling" EXACT [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase II promoter of calcium signaling" EXACT [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase II promoter of calcium signalling" EXACT [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase II promoter of calcium-mediated signalling" EXACT [GOC:TermGenie]
is_obsolete: true
replaced_by: GO:1900622
created_by: dph
creation_date: 2012-01-26T01:42:53Z

[Term]
id: GO:1900062
name: regulation of replicative cell aging
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of replicative cell aging." [GOC:TermGenie, PMID:17914901]
synonym: "regulation of replicative cell ageing" EXACT [GOC:TermGenie]
is_a: GO:0090342 ! regulation of cell aging
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001302 ! replicative cell aging
relationship: regulates GO:0001302 ! replicative cell aging
created_by: dph
creation_date: 2012-01-26T01:46:47Z

[Term]
id: GO:1900063
name: regulation of peroxisome organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of peroxisome organization." [GOC:TermGenie, PMID:7500953]
synonym: "regulation of peroxisome organisation" EXACT [GOC:TermGenie]
synonym: "regulation of peroxisome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "regulation of peroxisome-assembly ATPase activity" RELATED [GOC:TermGenie]
is_a: GO:0033043 ! regulation of organelle organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007031 ! peroxisome organization
relationship: regulates GO:0007031 ! peroxisome organization
created_by: dph
creation_date: 2012-01-26T01:49:05Z

[Term]
id: GO:1900064
name: positive regulation of peroxisome organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of peroxisome organization." [GOC:TermGenie, PMID:7500953]
synonym: "activation of peroxisome organisation" NARROW [GOC:TermGenie]
synonym: "activation of peroxisome organization" NARROW [GOC:TermGenie]
synonym: "activation of peroxisome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "activation of peroxisome-assembly ATPase activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of peroxisome organisation" EXACT [GOC:TermGenie]
synonym: "positive regulation of peroxisome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of peroxisome-assembly ATPase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of peroxisome organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of peroxisome organization" RELATED [GOC:TermGenie]
synonym: "up regulation of peroxisome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "up regulation of peroxisome-assembly ATPase activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of peroxisome organisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of peroxisome organization" RELATED [GOC:TermGenie]
synonym: "up-regulation of peroxisome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of peroxisome-assembly ATPase activity" RELATED [GOC:TermGenie]
synonym: "upregulation of peroxisome organisation" EXACT [GOC:TermGenie]
synonym: "upregulation of peroxisome organization" RELATED [GOC:TermGenie]
synonym: "upregulation of peroxisome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "upregulation of peroxisome-assembly ATPase activity" RELATED [GOC:TermGenie]
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:1900063 ! regulation of peroxisome organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007031 ! peroxisome organization
relationship: positively_regulates GO:0007031 ! peroxisome organization
created_by: dph
creation_date: 2012-01-26T01:49:09Z

[Term]
id: GO:1900065
name: regulation of ethanol catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ethanol catabolic process." [GOC:TermGenie, PMID:10608811, PMID:7760841]
synonym: "regulation of ethanol breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of ethanol catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of ethanol degradation" EXACT [GOC:TermGenie]
is_a: GO:0009894 ! regulation of catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006068 ! ethanol catabolic process
relationship: regulates GO:0006068 ! ethanol catabolic process
created_by: dph
creation_date: 2012-01-26T01:51:40Z

[Term]
id: GO:1900066
name: positive regulation of ethanol catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ethanol catabolic process." [GOC:TermGenie, PMID:10608811, PMID:7760841]
synonym: "activation of ethanol breakdown" NARROW [GOC:TermGenie]
synonym: "activation of ethanol catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of ethanol catabolism" NARROW [GOC:TermGenie]
synonym: "activation of ethanol degradation" NARROW [GOC:TermGenie]
synonym: "positive regulation of ethanol breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of ethanol catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of ethanol degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of ethanol breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of ethanol catabolic process" RELATED [GOC:TermGenie]
synonym: "up regulation of ethanol catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of ethanol degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of ethanol breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of ethanol catabolic process" RELATED [GOC:TermGenie]
synonym: "up-regulation of ethanol catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of ethanol degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of ethanol breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of ethanol catabolic process" RELATED [GOC:TermGenie]
synonym: "upregulation of ethanol catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of ethanol degradation" EXACT [GOC:TermGenie]
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:1900065 ! regulation of ethanol catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006068 ! ethanol catabolic process
relationship: positively_regulates GO:0006068 ! ethanol catabolic process
created_by: dph
creation_date: 2012-01-26T01:51:44Z

[Term]
id: GO:1900067
name: regulation of cellular response to alkaline pH
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular response to alkalinity." [GOC:dgf, GOC:TermGenie, PMID:12509465, PMID:17023428]
synonym: "regulation of cellular response to alkalinity" BROAD []
synonym: "regulation of cellular response to basic pH" EXACT [GOC:TermGenie]
is_a: GO:0048583 ! regulation of response to stimulus
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071469 ! cellular response to alkaline pH
relationship: regulates GO:0071469 ! cellular response to alkaline pH
created_by: pr
creation_date: 2012-01-26T02:34:59Z

[Term]
id: GO:1900068
name: negative regulation of cellular response to alkaline pH
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to alkalinity." [GOC:dgf, GOC:TermGenie, PMID:12509465, PMID:17023428]
synonym: "down regulation of cellular response to alkaline pH" EXACT [GOC:TermGenie]
synonym: "down regulation of cellular response to alkalinity" RELATED [GOC:TermGenie]
synonym: "down regulation of cellular response to basic pH" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular response to alkaline pH" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular response to alkalinity" RELATED [GOC:TermGenie]
synonym: "down-regulation of cellular response to basic pH" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular response to alkaline pH" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular response to alkalinity" RELATED [GOC:TermGenie]
synonym: "downregulation of cellular response to basic pH" EXACT [GOC:TermGenie]
synonym: "inhibition of cellular response to alkaline pH" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular response to alkalinity" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular response to basic pH" NARROW [GOC:TermGenie]
synonym: "negative regulation of cellular response to alkalinity" BROAD []
synonym: "negative regulation of cellular response to basic pH" EXACT [GOC:TermGenie]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1900067 ! regulation of cellular response to alkaline pH
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071469 ! cellular response to alkaline pH
relationship: negatively_regulates GO:0071469 ! cellular response to alkaline pH
created_by: pr
creation_date: 2012-01-26T02:35:03Z

[Term]
id: GO:1900069
name: regulation of cellular hyperosmotic salinity response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular hyperosmotic salinity response." [GOC:dgf, GOC:TermGenie, PMID:16278455]
synonym: "regulation of cellular response to hyperosmotic salt stress" EXACT [GOC:TermGenie]
is_a: GO:0080135 ! regulation of cellular response to stress
is_a: GO:1901000 ! regulation of response to salt stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071475 ! cellular hyperosmotic salinity response
relationship: regulates GO:0071475 ! cellular hyperosmotic salinity response
created_by: pr
creation_date: 2012-01-26T02:45:39Z

[Term]
id: GO:1900070
name: negative regulation of cellular hyperosmotic salinity response
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular hyperosmotic salinity response." [GOC:dgf, GOC:TermGenie, PMID:16278455]
synonym: "down regulation of cellular hyperosmotic salinity response" RELATED [GOC:TermGenie]
synonym: "down regulation of cellular response to hyperosmotic salt stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular hyperosmotic salinity response" RELATED [GOC:TermGenie]
synonym: "down-regulation of cellular response to hyperosmotic salt stress" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular hyperosmotic salinity response" RELATED [GOC:TermGenie]
synonym: "downregulation of cellular response to hyperosmotic salt stress" EXACT [GOC:TermGenie]
synonym: "inhibition of cellular hyperosmotic salinity response" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular response to hyperosmotic salt stress" NARROW [GOC:TermGenie]
synonym: "negative regulation of cellular response to hyperosmotic salt stress" EXACT [GOC:TermGenie]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:1900069 ! regulation of cellular hyperosmotic salinity response
is_a: GO:1901001 ! negative regulation of response to salt stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071475 ! cellular hyperosmotic salinity response
relationship: negatively_regulates GO:0071475 ! cellular hyperosmotic salinity response
created_by: pr
creation_date: 2012-01-26T02:45:43Z

[Term]
id: GO:1900071
name: regulation of sulfite transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sulfite transport." [GOC:TermGenie, PMID:10234785, PMID:10870099]
synonym: "regulation of sulphite transport" EXACT [GOC:TermGenie]
is_a: GO:0044070 ! regulation of anion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000316 ! sulfite transport
relationship: regulates GO:0000316 ! sulfite transport
created_by: dph
creation_date: 2012-01-26T08:41:10Z

[Term]
id: GO:1900072
name: positive regulation of sulfite transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sulfite transport." [GOC:TermGenie, PMID:10234785, PMID:10870099]
synonym: "activation of sulfite transport" NARROW [GOC:TermGenie]
synonym: "activation of sulphite transport" NARROW [GOC:TermGenie]
synonym: "positive regulation of sulphite transport" EXACT [GOC:TermGenie]
synonym: "up regulation of sulfite transport" RELATED [GOC:TermGenie]
synonym: "up regulation of sulphite transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of sulfite transport" RELATED [GOC:TermGenie]
synonym: "up-regulation of sulphite transport" EXACT [GOC:TermGenie]
synonym: "upregulation of sulfite transport" RELATED [GOC:TermGenie]
synonym: "upregulation of sulphite transport" EXACT [GOC:TermGenie]
is_a: GO:1900071 ! regulation of sulfite transport
is_a: GO:1903793 ! positive regulation of anion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000316 ! sulfite transport
relationship: positively_regulates GO:0000316 ! sulfite transport
created_by: dph
creation_date: 2012-01-26T08:41:16Z

[Term]
id: GO:1900073
name: regulation of neuromuscular synaptic transmission
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neuromuscular synaptic transmission." [GOC:kmv, GOC:TermGenie]
is_a: GO:0050804 ! modulation of synaptic transmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007274 ! neuromuscular synaptic transmission
relationship: regulates GO:0007274 ! neuromuscular synaptic transmission
created_by: kmv
creation_date: 2012-01-26T10:14:10Z

[Term]
id: GO:1900074
name: negative regulation of neuromuscular synaptic transmission
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuromuscular synaptic transmission." [GOC:kmv, GOC:TermGenie]
synonym: "down regulation of neuromuscular synaptic transmission" RELATED [GOC:TermGenie]
synonym: "down-regulation of neuromuscular synaptic transmission" RELATED [GOC:TermGenie]
synonym: "downregulation of neuromuscular synaptic transmission" RELATED [GOC:TermGenie]
synonym: "inhibition of neuromuscular synaptic transmission" RELATED [GOC:TermGenie]
is_a: GO:0050805 ! negative regulation of synaptic transmission
is_a: GO:1900073 ! regulation of neuromuscular synaptic transmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007274 ! neuromuscular synaptic transmission
relationship: negatively_regulates GO:0007274 ! neuromuscular synaptic transmission
created_by: kmv
creation_date: 2012-01-26T10:14:18Z

[Term]
id: GO:1900075
name: positive regulation of neuromuscular synaptic transmission
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neuromuscular synaptic transmission." [GOC:kmv, GOC:TermGenie]
synonym: "activation of neuromuscular synaptic transmission" RELATED [GOC:TermGenie]
synonym: "up regulation of neuromuscular synaptic transmission" RELATED [GOC:TermGenie]
synonym: "up-regulation of neuromuscular synaptic transmission" RELATED [GOC:TermGenie]
synonym: "upregulation of neuromuscular synaptic transmission" RELATED [GOC:TermGenie]
is_a: GO:0050806 ! positive regulation of synaptic transmission
is_a: GO:1900073 ! regulation of neuromuscular synaptic transmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007274 ! neuromuscular synaptic transmission
relationship: positively_regulates GO:0007274 ! neuromuscular synaptic transmission
created_by: kmv
creation_date: 2012-01-26T10:14:22Z

[Term]
id: GO:1900076
name: regulation of cellular response to insulin stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular response to insulin stimulus." [GOC:TermGenie, GOC:yaf]
is_a: GO:0048583 ! regulation of response to stimulus
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032869 ! cellular response to insulin stimulus
relationship: regulates GO:0032869 ! cellular response to insulin stimulus
created_by: yaf
creation_date: 2012-01-31T11:22:22Z

[Term]
id: GO:1900077
name: negative regulation of cellular response to insulin stimulus
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to insulin stimulus." [GOC:TermGenie, GOC:yaf]
synonym: "down regulation of cellular response to insulin stimulus" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular response to insulin stimulus" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular response to insulin stimulus" EXACT [GOC:TermGenie]
synonym: "inhibition of cellular response to insulin stimulus" NARROW [GOC:TermGenie]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1900076 ! regulation of cellular response to insulin stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032869 ! cellular response to insulin stimulus
relationship: negatively_regulates GO:0032869 ! cellular response to insulin stimulus
created_by: yaf
creation_date: 2012-01-31T11:23:15Z

[Term]
id: GO:1900078
name: positive regulation of cellular response to insulin stimulus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellular response to insulin stimulus." [GOC:TermGenie, GOC:yaf]
synonym: "activation of cellular response to insulin stimulus" NARROW [GOC:TermGenie]
synonym: "up regulation of cellular response to insulin stimulus" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular response to insulin stimulus" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular response to insulin stimulus" EXACT [GOC:TermGenie]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1900076 ! regulation of cellular response to insulin stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032869 ! cellular response to insulin stimulus
relationship: positively_regulates GO:0032869 ! cellular response to insulin stimulus
created_by: yaf
creation_date: 2012-01-31T11:24:30Z

[Term]
id: GO:1900079
name: regulation of arginine biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of arginine biosynthetic process." [GOC:dgf, GOC:TermGenie]
synonym: "regulation of arginine anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of arginine biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of arginine formation" EXACT [GOC:TermGenie]
synonym: "regulation of arginine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0000821 ! regulation of arginine metabolic process
is_a: GO:2000282 ! regulation of cellular amino acid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006526 ! arginine biosynthetic process
relationship: regulates GO:0006526 ! arginine biosynthetic process
created_by: pr
creation_date: 2012-02-01T03:57:36Z

[Term]
id: GO:1900080
name: positive regulation of arginine biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of arginine biosynthetic process." [GOC:dgf, GOC:TermGenie]
synonym: "activation of arginine anabolism" NARROW [GOC:TermGenie]
synonym: "activation of arginine biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of arginine biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of arginine formation" NARROW [GOC:TermGenie]
synonym: "activation of arginine synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of arginine anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of arginine biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of arginine formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of arginine synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of arginine anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of arginine biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of arginine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of arginine formation" EXACT [GOC:TermGenie]
synonym: "up regulation of arginine synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of arginine anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of arginine biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of arginine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of arginine formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of arginine synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of arginine anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of arginine biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of arginine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of arginine formation" EXACT [GOC:TermGenie]
synonym: "upregulation of arginine synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900079 ! regulation of arginine biosynthetic process
is_a: GO:2000284 ! positive regulation of cellular amino acid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006526 ! arginine biosynthetic process
relationship: positively_regulates GO:0006526 ! arginine biosynthetic process
created_by: pr
creation_date: 2012-02-01T03:57:41Z

[Term]
id: GO:1900081
name: regulation of arginine catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of arginine catabolic process." [GOC:dgf, GOC:TermGenie]
synonym: "regulation of arginine breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of arginine catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of arginine degradation" EXACT [GOC:TermGenie]
is_a: GO:0000821 ! regulation of arginine metabolic process
is_a: GO:0033241 ! regulation of cellular amine catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006527 ! arginine catabolic process
relationship: regulates GO:0006527 ! arginine catabolic process
created_by: pr
creation_date: 2012-02-01T04:04:39Z

[Term]
id: GO:1900082
name: negative regulation of arginine catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of arginine catabolic process." [GOC:dgf, GOC:TermGenie]
synonym: "down regulation of arginine breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of arginine catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of arginine catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of arginine degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of arginine breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of arginine catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of arginine catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of arginine degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of arginine breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of arginine catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of arginine catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of arginine degradation" EXACT [GOC:TermGenie]
synonym: "inhibition of arginine breakdown" NARROW [GOC:TermGenie]
synonym: "inhibition of arginine catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of arginine catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of arginine degradation" NARROW [GOC:TermGenie]
synonym: "negative regulation of arginine breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of arginine catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of arginine degradation" EXACT [GOC:TermGenie]
is_a: GO:0033242 ! negative regulation of cellular amine catabolic process
is_a: GO:0045763 ! negative regulation of cellular amino acid metabolic process
is_a: GO:1900081 ! regulation of arginine catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006527 ! arginine catabolic process
relationship: negatively_regulates GO:0006527 ! arginine catabolic process
created_by: pr
creation_date: 2012-02-01T04:04:45Z

[Term]
id: GO:1900083
name: obsolete regulation of Sertoli cell proliferation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of Sertoli cell proliferation." [GOC:pr, GOC:TermGenie]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "regulation of Sertoli cell proliferation" EXACT []
is_obsolete: true
created_by: pr
creation_date: 2012-02-02T03:10:50Z

[Term]
id: GO:1900084
name: regulation of peptidyl-tyrosine autophosphorylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of peptidyl-tyrosine autophosphorylation." [GOC:bf, GOC:TermGenie]
synonym: "regulation of receptor tyrosine kinase autophosphorylation" NARROW [GOC:TermGenie]
synonym: "regulation of tyrosine autophosphorylation" EXACT [GOC:TermGenie]
is_a: GO:0031952 ! regulation of protein autophosphorylation
is_a: GO:0050730 ! regulation of peptidyl-tyrosine phosphorylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0038083 ! peptidyl-tyrosine autophosphorylation
relationship: regulates GO:0038083 ! peptidyl-tyrosine autophosphorylation
created_by: bf
creation_date: 2012-02-03T10:17:07Z

[Term]
id: GO:1900085
name: negative regulation of peptidyl-tyrosine autophosphorylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-tyrosine autophosphorylation." [GOC:bf, GOC:TermGenie]
synonym: "down regulation of peptidyl-tyrosine autophosphorylation" EXACT [GOC:TermGenie]
synonym: "down regulation of receptor tyrosine kinase autophosphorylation" NARROW [GOC:TermGenie]
synonym: "down regulation of tyrosine autophosphorylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of peptidyl-tyrosine autophosphorylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of receptor tyrosine kinase autophosphorylation" NARROW [GOC:TermGenie]
synonym: "down-regulation of tyrosine autophosphorylation" EXACT [GOC:TermGenie]
synonym: "downregulation of peptidyl-tyrosine autophosphorylation" EXACT [GOC:TermGenie]
synonym: "downregulation of receptor tyrosine kinase autophosphorylation" NARROW [GOC:TermGenie]
synonym: "downregulation of tyrosine autophosphorylation" EXACT [GOC:TermGenie]
synonym: "inhibition of peptidyl-tyrosine autophosphorylation" NARROW [GOC:TermGenie]
synonym: "inhibition of receptor tyrosine kinase autophosphorylation" NARROW [GOC:TermGenie]
synonym: "inhibition of tyrosine autophosphorylation" NARROW [GOC:TermGenie]
synonym: "negative regulation of receptor tyrosine kinase autophosphorylation" NARROW [GOC:TermGenie]
synonym: "negative regulation of tyrosine autophosphorylation" EXACT [GOC:TermGenie]
is_a: GO:0031953 ! negative regulation of protein autophosphorylation
is_a: GO:0050732 ! negative regulation of peptidyl-tyrosine phosphorylation
is_a: GO:1900084 ! regulation of peptidyl-tyrosine autophosphorylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0038083 ! peptidyl-tyrosine autophosphorylation
relationship: negatively_regulates GO:0038083 ! peptidyl-tyrosine autophosphorylation
created_by: bf
creation_date: 2012-02-03T10:17:12Z

[Term]
id: GO:1900086
name: positive regulation of peptidyl-tyrosine autophosphorylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of peptidyl-tyrosine autophosphorylation." [GOC:bf, GOC:TermGenie]
synonym: "activation of peptidyl-tyrosine autophosphorylation" NARROW [GOC:TermGenie]
synonym: "activation of receptor tyrosine kinase autophosphorylation" NARROW [GOC:TermGenie]
synonym: "activation of tyrosine autophosphorylation" NARROW [GOC:TermGenie]
synonym: "positive regulation of receptor tyrosine kinase autophosphorylation" NARROW [GOC:TermGenie]
synonym: "positive regulation of tyrosine autophosphorylation" EXACT [GOC:TermGenie]
synonym: "up regulation of peptidyl-tyrosine autophosphorylation" EXACT [GOC:TermGenie]
synonym: "up regulation of receptor tyrosine kinase autophosphorylation" NARROW [GOC:TermGenie]
synonym: "up regulation of tyrosine autophosphorylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of peptidyl-tyrosine autophosphorylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of receptor tyrosine kinase autophosphorylation" NARROW [GOC:TermGenie]
synonym: "up-regulation of tyrosine autophosphorylation" EXACT [GOC:TermGenie]
synonym: "upregulation of peptidyl-tyrosine autophosphorylation" EXACT [GOC:TermGenie]
synonym: "upregulation of receptor tyrosine kinase autophosphorylation" NARROW [GOC:TermGenie]
synonym: "upregulation of tyrosine autophosphorylation" EXACT [GOC:TermGenie]
is_a: GO:0031954 ! positive regulation of protein autophosphorylation
is_a: GO:0050731 ! positive regulation of peptidyl-tyrosine phosphorylation
is_a: GO:1900084 ! regulation of peptidyl-tyrosine autophosphorylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0038083 ! peptidyl-tyrosine autophosphorylation
relationship: positively_regulates GO:0038083 ! peptidyl-tyrosine autophosphorylation
created_by: bf
creation_date: 2012-02-03T10:17:15Z

[Term]
id: GO:1900087
name: positive regulation of G1/S transition of mitotic cell cycle
namespace: biological_process
def: "Any cell cycle regulatory process that promotes the commitment of a cell from G1 to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle]
synonym: "activation of G1/S transition of mitotic cell cycle" NARROW [GOC:TermGenie]
synonym: "up regulation of G1/S transition of mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "up-regulation of G1/S transition of mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "upregulation of G1/S transition of mitotic cell cycle" EXACT [GOC:TermGenie]
is_a: GO:1901992 ! positive regulation of mitotic cell cycle phase transition
is_a: GO:1902808 ! positive regulation of cell cycle G1/S phase transition
is_a: GO:2000045 ! regulation of G1/S transition of mitotic cell cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000082 ! G1/S transition of mitotic cell cycle
relationship: positively_regulates GO:0000082 ! G1/S transition of mitotic cell cycle
created_by: rph
creation_date: 2012-02-08T12:24:39Z

[Term]
id: GO:1900088
name: regulation of inositol biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of inositol biosynthetic process." [GOC:TermGenie, PMID:22307851]
synonym: "regulation of inositol anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of inositol biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of inositol formation" EXACT [GOC:TermGenie]
synonym: "regulation of inositol synthesis" EXACT [GOC:TermGenie]
synonym: "regulation of myo-inositol biosynthesis" NARROW [GOC:TermGenie]
synonym: "regulation of myo-inositol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "regulation of vitamin Bh biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of vitamin Bh biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process
is_a: GO:1902930 ! regulation of alcohol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006021 ! inositol biosynthetic process
relationship: regulates GO:0006021 ! inositol biosynthetic process
created_by: dhl
creation_date: 2012-02-08T06:27:11Z

[Term]
id: GO:1900089
name: negative regulation of inositol biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of inositol biosynthetic process." [GOC:TermGenie, PMID:22307851]
synonym: "down regulation of inositol anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of inositol biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of inositol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of inositol formation" EXACT [GOC:TermGenie]
synonym: "down regulation of inositol synthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of myo-inositol biosynthesis" NARROW [GOC:TermGenie]
synonym: "down regulation of myo-inositol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "down regulation of vitamin Bh biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of vitamin Bh biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of inositol anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of inositol biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of inositol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of inositol formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of inositol synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of myo-inositol biosynthesis" NARROW [GOC:TermGenie]
synonym: "down-regulation of myo-inositol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "down-regulation of vitamin Bh biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of vitamin Bh biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of inositol anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of inositol biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of inositol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of inositol formation" EXACT [GOC:TermGenie]
synonym: "downregulation of inositol synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of myo-inositol biosynthesis" NARROW [GOC:TermGenie]
synonym: "downregulation of myo-inositol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "downregulation of vitamin Bh biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of vitamin Bh biosynthetic process" EXACT [GOC:TermGenie]
synonym: "inhibition of inositol anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of inositol biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of inositol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of inositol formation" EXACT [GOC:TermGenie]
synonym: "inhibition of inositol synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of myo-inositol biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of myo-inositol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of vitamin Bh biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of vitamin Bh biosynthetic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of inositol anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of inositol biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of inositol formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of inositol synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of myo-inositol biosynthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of myo-inositol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of vitamin Bh biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of vitamin Bh biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:1900088 ! regulation of inositol biosynthetic process
is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006021 ! inositol biosynthetic process
relationship: negatively_regulates GO:0006021 ! inositol biosynthetic process
created_by: dhl
creation_date: 2012-02-08T06:27:28Z

[Term]
id: GO:1900090
name: positive regulation of inositol biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of inositol biosynthetic process." [GOC:TermGenie, PMID:22307851]
synonym: "activation of inositol anabolism" EXACT [GOC:TermGenie]
synonym: "activation of inositol biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of inositol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of inositol formation" EXACT [GOC:TermGenie]
synonym: "activation of inositol synthesis" EXACT [GOC:TermGenie]
synonym: "activation of myo-inositol biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of myo-inositol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of vitamin Bh biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of vitamin Bh biosynthetic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of inositol anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of inositol biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of inositol formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of inositol synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of myo-inositol biosynthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of myo-inositol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of vitamin Bh biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of vitamin Bh biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of inositol anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of inositol biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of inositol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of inositol formation" EXACT [GOC:TermGenie]
synonym: "up regulation of inositol synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of myo-inositol biosynthesis" NARROW [GOC:TermGenie]
synonym: "up regulation of myo-inositol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "up regulation of vitamin Bh biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of vitamin Bh biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of inositol anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of inositol biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of inositol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of inositol formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of inositol synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of myo-inositol biosynthesis" NARROW [GOC:TermGenie]
synonym: "up-regulation of myo-inositol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "up-regulation of vitamin Bh biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of vitamin Bh biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of inositol anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of inositol biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of inositol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of inositol formation" EXACT [GOC:TermGenie]
synonym: "upregulation of inositol synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of myo-inositol biosynthesis" NARROW [GOC:TermGenie]
synonym: "upregulation of myo-inositol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "upregulation of vitamin Bh biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of vitamin Bh biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:1900088 ! regulation of inositol biosynthetic process
is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006021 ! inositol biosynthetic process
relationship: positively_regulates GO:0006021 ! inositol biosynthetic process
created_by: dhl
creation_date: 2012-02-08T06:27:31Z

[Term]
id: GO:1900091
name: regulation of raffinose biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of raffinose biosynthetic process." [GOC:TermGenie, PMID:22307851]
synonym: "regulation of raffinose anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of raffinose biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of raffinose formation" EXACT [GOC:TermGenie]
synonym: "regulation of raffinose synthesis" EXACT [GOC:TermGenie]
is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process
is_a: GO:0080091 ! regulation of raffinose metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0033529 ! raffinose biosynthetic process
relationship: regulates GO:0033529 ! raffinose biosynthetic process
created_by: dhl
creation_date: 2012-02-08T06:31:54Z

[Term]
id: GO:1900092
name: negative regulation of raffinose biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of raffinose biosynthetic process." [GOC:TermGenie, PMID:22307851]
synonym: "down regulation of raffinose anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of raffinose biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of raffinose biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of raffinose formation" EXACT [GOC:TermGenie]
synonym: "down regulation of raffinose synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of raffinose anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of raffinose biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of raffinose biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of raffinose formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of raffinose synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of raffinose anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of raffinose biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of raffinose biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of raffinose formation" EXACT [GOC:TermGenie]
synonym: "downregulation of raffinose synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of raffinose anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of raffinose biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of raffinose biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of raffinose formation" EXACT [GOC:TermGenie]
synonym: "inhibition of raffinose synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of raffinose anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of raffinose biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of raffinose formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of raffinose synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:1900091 ! regulation of raffinose biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0033529 ! raffinose biosynthetic process
relationship: negatively_regulates GO:0033529 ! raffinose biosynthetic process
created_by: dhl
creation_date: 2012-02-08T06:31:58Z

[Term]
id: GO:1900093
name: positive regulation of raffinose biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of raffinose biosynthetic process." [GOC:TermGenie, PMID:22307851]
synonym: "activation of raffinose anabolism" EXACT [GOC:TermGenie]
synonym: "activation of raffinose biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of raffinose biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of raffinose formation" EXACT [GOC:TermGenie]
synonym: "activation of raffinose synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of raffinose anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of raffinose biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of raffinose formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of raffinose synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of raffinose anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of raffinose biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of raffinose biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of raffinose formation" EXACT [GOC:TermGenie]
synonym: "up regulation of raffinose synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of raffinose anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of raffinose biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of raffinose biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of raffinose formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of raffinose synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of raffinose anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of raffinose biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of raffinose biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of raffinose formation" EXACT [GOC:TermGenie]
synonym: "upregulation of raffinose synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process
is_a: GO:1900091 ! regulation of raffinose biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0033529 ! raffinose biosynthetic process
relationship: positively_regulates GO:0033529 ! raffinose biosynthetic process
created_by: dhl
creation_date: 2012-02-08T06:32:01Z

[Term]
id: GO:1900094
name: regulation of transcription from RNA polymerase II promoter involved in determination of left/right symmetry
namespace: biological_process
def: "Any regulation of transcription from RNA polymerase II promoter that is involved in determination of left/right symmetry." [GOC:BHF, GOC:TermGenie]
synonym: "global transcription regulation from Pol II promoter of determination of left/right asymmetry" RELATED [GOC:TermGenie]
synonym: "global transcription regulation from Pol II promoter of determination of left/right symmetry" RELATED [GOC:TermGenie]
synonym: "regulation of gene-specific transcription from RNA polymerase II promoter of determination of left/right asymmetry" RELATED [GOC:TermGenie]
synonym: "regulation of gene-specific transcription from RNA polymerase II promoter of determination of left/right symmetry" RELATED [GOC:TermGenie]
synonym: "regulation of global transcription from Pol II promoter of determination of left/right asymmetry" RELATED [GOC:TermGenie]
synonym: "regulation of global transcription from Pol II promoter of determination of left/right symmetry" RELATED [GOC:TermGenie]
synonym: "regulation of transcription from Pol II promoter of determination of left/right asymmetry" EXACT [GOC:TermGenie]
synonym: "regulation of transcription from Pol II promoter of determination of left/right symmetry" EXACT [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter of determination of left/right asymmetry" EXACT [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter of determination of left/right symmetry" EXACT [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter, global of determination of left/right asymmetry" RELATED [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter, global of determination of left/right symmetry" RELATED [GOC:TermGenie]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
intersection_of: part_of GO:0007368 ! determination of left/right symmetry
relationship: part_of GO:0007368 ! determination of left/right symmetry
created_by: vk
creation_date: 2012-02-14T10:58:20Z

[Term]
id: GO:1900095
name: regulation of dosage compensation by inactivation of X chromosome
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dosage compensation, by inactivation of X chromosome." [GOC:TermGenie]
synonym: "regulation of Barr body formation" RELATED [GOC:TermGenie]
synonym: "regulation of chromosome inactivation" BROAD [GOC:TermGenie]
synonym: "regulation of X chromosome inactivation" EXACT [GOC:TermGenie]
is_a: GO:0010468 ! regulation of gene expression
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009048 ! dosage compensation by inactivation of X chromosome
relationship: regulates GO:0009048 ! dosage compensation by inactivation of X chromosome
created_by: hjd
creation_date: 2012-02-14T07:29:45Z

[Term]
id: GO:1900096
name: negative regulation of dosage compensation by inactivation of X chromosome
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of dosage compensation, by inactivation of X chromosome." [GOC:TermGenie]
synonym: "down regulation of Barr body formation" RELATED [GOC:TermGenie]
synonym: "down regulation of chromosome inactivation" BROAD [GOC:TermGenie]
synonym: "down regulation of dosage compensation, by inactivation of X chromosome" EXACT [GOC:TermGenie]
synonym: "down regulation of X chromosome inactivation" EXACT [GOC:TermGenie]
synonym: "down-regulation of Barr body formation" RELATED [GOC:TermGenie]
synonym: "down-regulation of chromosome inactivation" BROAD [GOC:TermGenie]
synonym: "down-regulation of dosage compensation, by inactivation of X chromosome" EXACT [GOC:TermGenie]
synonym: "down-regulation of X chromosome inactivation" EXACT [GOC:TermGenie]
synonym: "downregulation of Barr body formation" RELATED [GOC:TermGenie]
synonym: "downregulation of chromosome inactivation" BROAD [GOC:TermGenie]
synonym: "downregulation of dosage compensation, by inactivation of X chromosome" EXACT [GOC:TermGenie]
synonym: "downregulation of X chromosome inactivation" EXACT [GOC:TermGenie]
synonym: "inhibition of Barr body formation" RELATED [GOC:TermGenie]
synonym: "inhibition of chromosome inactivation" BROAD [GOC:TermGenie]
synonym: "inhibition of dosage compensation, by inactivation of X chromosome" NARROW [GOC:TermGenie]
synonym: "inhibition of X chromosome inactivation" EXACT [GOC:TermGenie]
synonym: "negative regulation of Barr body formation" RELATED [GOC:TermGenie]
synonym: "negative regulation of chromosome inactivation" BROAD [GOC:TermGenie]
synonym: "negative regulation of X chromosome inactivation" EXACT [GOC:TermGenie]
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:1900095 ! regulation of dosage compensation by inactivation of X chromosome
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009048 ! dosage compensation by inactivation of X chromosome
relationship: negatively_regulates GO:0009048 ! dosage compensation by inactivation of X chromosome
created_by: hjd
creation_date: 2012-02-14T07:29:49Z

[Term]
id: GO:1900097
name: positive regulation of dosage compensation by inactivation of X chromosome
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of dosage compensation, by inactivation of X chromosome." [GOC:TermGenie]
synonym: "activation of Barr body formation" RELATED [GOC:TermGenie]
synonym: "activation of chromosome inactivation" BROAD [GOC:TermGenie]
synonym: "activation of dosage compensation, by inactivation of X chromosome" NARROW [GOC:TermGenie]
synonym: "activation of X chromosome inactivation" EXACT [GOC:TermGenie]
synonym: "positive regulation of Barr body formation" RELATED [GOC:TermGenie]
synonym: "positive regulation of chromosome inactivation" BROAD [GOC:TermGenie]
synonym: "positive regulation of X chromosome inactivation" EXACT [GOC:TermGenie]
synonym: "up regulation of Barr body formation" RELATED [GOC:TermGenie]
synonym: "up regulation of chromosome inactivation" BROAD [GOC:TermGenie]
synonym: "up regulation of dosage compensation, by inactivation of X chromosome" EXACT [GOC:TermGenie]
synonym: "up regulation of X chromosome inactivation" EXACT [GOC:TermGenie]
synonym: "up-regulation of Barr body formation" RELATED [GOC:TermGenie]
synonym: "up-regulation of chromosome inactivation" BROAD [GOC:TermGenie]
synonym: "up-regulation of dosage compensation, by inactivation of X chromosome" EXACT [GOC:TermGenie]
synonym: "up-regulation of X chromosome inactivation" EXACT [GOC:TermGenie]
synonym: "upregulation of Barr body formation" RELATED [GOC:TermGenie]
synonym: "upregulation of chromosome inactivation" BROAD [GOC:TermGenie]
synonym: "upregulation of dosage compensation, by inactivation of X chromosome" EXACT [GOC:TermGenie]
synonym: "upregulation of X chromosome inactivation" EXACT [GOC:TermGenie]
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:1900095 ! regulation of dosage compensation by inactivation of X chromosome
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009048 ! dosage compensation by inactivation of X chromosome
relationship: positively_regulates GO:0009048 ! dosage compensation by inactivation of X chromosome
created_by: hjd
creation_date: 2012-02-14T07:29:52Z

[Term]
id: GO:1900098
name: regulation of plasma cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of plasma cell differentiation." [GOC:TermGenie]
synonym: "regulation of plasma cell development" RELATED [GOC:TermGenie]
is_a: GO:0002697 ! regulation of immune effector process
is_a: GO:0045577 ! regulation of B cell differentiation
is_a: GO:0050776 ! regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002317 ! plasma cell differentiation
relationship: regulates GO:0002317 ! plasma cell differentiation
created_by: bf
creation_date: 2012-02-15T10:46:00Z

[Term]
id: GO:1900099
name: negative regulation of plasma cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of plasma cell differentiation." [GOC:TermGenie]
synonym: "down regulation of plasma cell development" RELATED [GOC:TermGenie]
synonym: "down regulation of plasma cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of plasma cell development" RELATED [GOC:TermGenie]
synonym: "down-regulation of plasma cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of plasma cell development" RELATED [GOC:TermGenie]
synonym: "downregulation of plasma cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of plasma cell development" RELATED [GOC:TermGenie]
synonym: "inhibition of plasma cell differentiation" NARROW [GOC:TermGenie]
synonym: "negative regulation of plasma cell development" RELATED [GOC:TermGenie]
is_a: GO:0002698 ! negative regulation of immune effector process
is_a: GO:0045578 ! negative regulation of B cell differentiation
is_a: GO:0050777 ! negative regulation of immune response
is_a: GO:1900098 ! regulation of plasma cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002317 ! plasma cell differentiation
relationship: negatively_regulates GO:0002317 ! plasma cell differentiation
created_by: bf
creation_date: 2012-02-15T10:46:05Z

[Term]
id: GO:1900100
name: positive regulation of plasma cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of plasma cell differentiation." [GOC:TermGenie]
synonym: "activation of plasma cell development" RELATED [GOC:TermGenie]
synonym: "activation of plasma cell differentiation" NARROW [GOC:TermGenie]
synonym: "positive regulation of plasma cell development" RELATED [GOC:TermGenie]
synonym: "up regulation of plasma cell development" RELATED [GOC:TermGenie]
synonym: "up regulation of plasma cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of plasma cell development" RELATED [GOC:TermGenie]
synonym: "up-regulation of plasma cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of plasma cell development" RELATED [GOC:TermGenie]
synonym: "upregulation of plasma cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0045579 ! positive regulation of B cell differentiation
is_a: GO:0050778 ! positive regulation of immune response
is_a: GO:1900098 ! regulation of plasma cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002317 ! plasma cell differentiation
relationship: positively_regulates GO:0002317 ! plasma cell differentiation
created_by: bf
creation_date: 2012-02-15T10:46:08Z

[Term]
id: GO:1900101
name: regulation of endoplasmic reticulum unfolded protein response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endoplasmic reticulum unfolded protein response." [GOC:TermGenie]
synonym: "regulation of ER unfolded protein response" EXACT [GOC:TermGenie]
synonym: "regulation of erUPR" EXACT [GOC:TermGenie]
synonym: "regulation of SREBP-mediated signalling pathway" RELATED [GOC:TermGenie]
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0080135 ! regulation of cellular response to stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030968 ! endoplasmic reticulum unfolded protein response
relationship: regulates GO:0030968 ! endoplasmic reticulum unfolded protein response
created_by: ppm
creation_date: 2012-02-15T11:15:27Z

[Term]
id: GO:1900102
name: negative regulation of endoplasmic reticulum unfolded protein response
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of endoplasmic reticulum unfolded protein response." [GOC:TermGenie]
synonym: "down regulation of endoplasmic reticulum unfolded protein response" EXACT [GOC:TermGenie]
synonym: "down regulation of ER unfolded protein response" EXACT [GOC:TermGenie]
synonym: "down regulation of erUPR" EXACT [GOC:TermGenie]
synonym: "down regulation of SREBP-mediated signalling pathway" RELATED [GOC:TermGenie]
synonym: "down-regulation of endoplasmic reticulum unfolded protein response" EXACT [GOC:TermGenie]
synonym: "down-regulation of ER unfolded protein response" EXACT [GOC:TermGenie]
synonym: "down-regulation of erUPR" EXACT [GOC:TermGenie]
synonym: "down-regulation of SREBP-mediated signalling pathway" RELATED [GOC:TermGenie]
synonym: "downregulation of endoplasmic reticulum unfolded protein response" EXACT [GOC:TermGenie]
synonym: "downregulation of ER unfolded protein response" EXACT [GOC:TermGenie]
synonym: "downregulation of erUPR" EXACT [GOC:TermGenie]
synonym: "downregulation of SREBP-mediated signalling pathway" RELATED [GOC:TermGenie]
synonym: "inhibition of endoplasmic reticulum unfolded protein response" NARROW [GOC:TermGenie]
synonym: "inhibition of ER unfolded protein response" EXACT [GOC:TermGenie]
synonym: "inhibition of erUPR" EXACT [GOC:TermGenie]
synonym: "inhibition of SREBP-mediated signalling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of ER unfolded protein response" EXACT [GOC:TermGenie]
synonym: "negative regulation of erUPR" EXACT [GOC:TermGenie]
synonym: "negative regulation of SREBP-mediated signalling pathway" RELATED [GOC:TermGenie]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:1900101 ! regulation of endoplasmic reticulum unfolded protein response
is_a: GO:1903573 ! negative regulation of response to endoplasmic reticulum stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030968 ! endoplasmic reticulum unfolded protein response
relationship: negatively_regulates GO:0030968 ! endoplasmic reticulum unfolded protein response
created_by: ppm
creation_date: 2012-02-15T11:15:31Z

[Term]
id: GO:1900103
name: positive regulation of endoplasmic reticulum unfolded protein response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endoplasmic reticulum unfolded protein response." [GOC:TermGenie]
synonym: "activation of endoplasmic reticulum unfolded protein response" NARROW [GOC:TermGenie]
synonym: "activation of ER unfolded protein response" EXACT [GOC:TermGenie]
synonym: "activation of erUPR" EXACT [GOC:TermGenie]
synonym: "activation of SREBP-mediated signalling pathway" RELATED [GOC:TermGenie]
synonym: "positive regulation of ER unfolded protein response" EXACT [GOC:TermGenie]
synonym: "positive regulation of erUPR" EXACT [GOC:TermGenie]
synonym: "positive regulation of SREBP-mediated signalling pathway" RELATED [GOC:TermGenie]
synonym: "up regulation of endoplasmic reticulum unfolded protein response" EXACT [GOC:TermGenie]
synonym: "up regulation of ER unfolded protein response" EXACT [GOC:TermGenie]
synonym: "up regulation of erUPR" EXACT [GOC:TermGenie]
synonym: "up regulation of SREBP-mediated signalling pathway" RELATED [GOC:TermGenie]
synonym: "up-regulation of endoplasmic reticulum unfolded protein response" EXACT [GOC:TermGenie]
synonym: "up-regulation of ER unfolded protein response" EXACT [GOC:TermGenie]
synonym: "up-regulation of erUPR" EXACT [GOC:TermGenie]
synonym: "up-regulation of SREBP-mediated signalling pathway" RELATED [GOC:TermGenie]
synonym: "upregulation of endoplasmic reticulum unfolded protein response" EXACT [GOC:TermGenie]
synonym: "upregulation of ER unfolded protein response" EXACT [GOC:TermGenie]
synonym: "upregulation of erUPR" EXACT [GOC:TermGenie]
synonym: "upregulation of SREBP-mediated signalling pathway" RELATED [GOC:TermGenie]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:1900101 ! regulation of endoplasmic reticulum unfolded protein response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030968 ! endoplasmic reticulum unfolded protein response
relationship: positively_regulates GO:0030968 ! endoplasmic reticulum unfolded protein response
created_by: ppm
creation_date: 2012-02-15T11:15:35Z

[Term]
id: GO:1900104
name: regulation of hyaluranon cable assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hyaluranon cable assembly." [GOC:TermGenie, GOC:yaf]
synonym: "regulation of HA cable assembly" EXACT [GOC:TermGenie]
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0036118 ! hyaluranon cable assembly
relationship: regulates GO:0036118 ! hyaluranon cable assembly
created_by: yaf
creation_date: 2012-02-16T01:00:41Z

[Term]
id: GO:1900105
name: negative regulation of hyaluranon cable assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hyaluranon cable assembly." [GOC:TermGenie, GOC:yaf]
synonym: "down regulation of HA cable assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of hyaluranon cable assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of HA cable assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of hyaluranon cable assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of HA cable assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of hyaluranon cable assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of HA cable assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of hyaluranon cable assembly" NARROW [GOC:TermGenie]
synonym: "negative regulation of HA cable assembly" EXACT [GOC:TermGenie]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1900104 ! regulation of hyaluranon cable assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0036118 ! hyaluranon cable assembly
relationship: negatively_regulates GO:0036118 ! hyaluranon cable assembly
created_by: yaf
creation_date: 2012-02-16T01:00:50Z

[Term]
id: GO:1900106
name: positive regulation of hyaluranon cable assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hyaluranon cable assembly." [GOC:TermGenie, GOC:yaf]
synonym: "activation of HA cable assembly" EXACT [GOC:TermGenie]
synonym: "activation of hyaluranon cable assembly" NARROW [GOC:TermGenie]
synonym: "positive regulation of HA cable assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of HA cable assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of hyaluranon cable assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of HA cable assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of hyaluranon cable assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of HA cable assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of hyaluranon cable assembly" EXACT [GOC:TermGenie]
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1900104 ! regulation of hyaluranon cable assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0036118 ! hyaluranon cable assembly
relationship: positively_regulates GO:0036118 ! hyaluranon cable assembly
created_by: yaf
creation_date: 2012-02-16T01:00:54Z

[Term]
id: GO:1900107
name: regulation of nodal signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nodal signaling pathway." [GOC:BHF, GOC:TermGenie, GOC:vk]
synonym: "regulation of nodal signaling" EXACT [GOC:TermGenie]
synonym: "regulation of nodal signalling pathway" EXACT [GOC:mah]
is_a: GO:0032925 ! regulation of activin receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0038092 ! nodal signaling pathway
relationship: regulates GO:0038092 ! nodal signaling pathway
created_by: bf
creation_date: 2012-02-16T03:34:19Z

[Term]
id: GO:1900108
name: negative regulation of nodal signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of nodal signaling pathway." [GOC:BHF, GOC:TermGenie, GOC:vk]
synonym: "down regulation of nodal signaling" EXACT [GOC:TermGenie]
synonym: "down regulation of nodal signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of nodal signaling" EXACT [GOC:TermGenie]
synonym: "down-regulation of nodal signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of nodal signaling" EXACT [GOC:TermGenie]
synonym: "downregulation of nodal signaling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of nodal signaling" NARROW [GOC:TermGenie]
synonym: "inhibition of nodal signaling pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of nodal signaling" EXACT [GOC:TermGenie]
synonym: "negative regulation of nodal signalling pathway" EXACT [GOC:mah]
is_a: GO:0032926 ! negative regulation of activin receptor signaling pathway
is_a: GO:1900107 ! regulation of nodal signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0038092 ! nodal signaling pathway
relationship: negatively_regulates GO:0038092 ! nodal signaling pathway
created_by: bf
creation_date: 2012-02-16T03:34:23Z

[Term]
id: GO:1900109
name: regulation of histone H3-K9 dimethylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of histone H3-K9 dimethylation." [GOC:TermGenie, GOC:vw]
synonym: "regulation of histone H3 K9 dimethylation" EXACT [GOC:TermGenie]
synonym: "regulation of histone lysine H3 K9 dimethylation" EXACT [GOC:TermGenie]
is_a: GO:0051570 ! regulation of histone H3-K9 methylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0036123 ! histone H3-K9 dimethylation
relationship: regulates GO:0036123 ! histone H3-K9 dimethylation
created_by: bf
creation_date: 2012-02-21T09:06:18Z

[Term]
id: GO:1900110
name: negative regulation of histone H3-K9 dimethylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K9 dimethylation." [GOC:TermGenie, GOC:vw]
synonym: "down regulation of histone H3 K9 dimethylation" EXACT [GOC:TermGenie]
synonym: "down regulation of histone H3-K9 dimethylation" EXACT [GOC:TermGenie]
synonym: "down regulation of histone lysine H3 K9 dimethylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of histone H3 K9 dimethylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of histone H3-K9 dimethylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of histone lysine H3 K9 dimethylation" EXACT [GOC:TermGenie]
synonym: "downregulation of histone H3 K9 dimethylation" EXACT [GOC:TermGenie]
synonym: "downregulation of histone H3-K9 dimethylation" EXACT [GOC:TermGenie]
synonym: "downregulation of histone lysine H3 K9 dimethylation" EXACT [GOC:TermGenie]
synonym: "inhibition of histone H3 K9 dimethylation" NARROW [GOC:TermGenie]
synonym: "inhibition of histone H3-K9 dimethylation" NARROW [GOC:TermGenie]
synonym: "inhibition of histone lysine H3 K9 dimethylation" NARROW [GOC:TermGenie]
synonym: "negative regulation of histone H3 K9 dimethylation" EXACT [GOC:TermGenie]
synonym: "negative regulation of histone lysine H3 K9 dimethylation" EXACT [GOC:TermGenie]
is_a: GO:0051573 ! negative regulation of histone H3-K9 methylation
is_a: GO:1900109 ! regulation of histone H3-K9 dimethylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0036123 ! histone H3-K9 dimethylation
relationship: negatively_regulates GO:0036123 ! histone H3-K9 dimethylation
created_by: bf
creation_date: 2012-02-21T09:06:22Z

[Term]
id: GO:1900111
name: positive regulation of histone H3-K9 dimethylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of histone H3-K9 dimethylation." [GOC:TermGenie, GOC:vw]
synonym: "activation of histone H3 K9 dimethylation" NARROW [GOC:TermGenie]
synonym: "activation of histone H3-K9 dimethylation" NARROW [GOC:TermGenie]
synonym: "activation of histone lysine H3 K9 dimethylation" NARROW [GOC:TermGenie]
synonym: "positive regulation of histone H3 K9 dimethylation" EXACT [GOC:TermGenie]
synonym: "positive regulation of histone lysine H3 K9 dimethylation" EXACT [GOC:TermGenie]
synonym: "up regulation of histone H3 K9 dimethylation" EXACT [GOC:TermGenie]
synonym: "up regulation of histone H3-K9 dimethylation" EXACT [GOC:TermGenie]
synonym: "up regulation of histone lysine H3 K9 dimethylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of histone H3 K9 dimethylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of histone H3-K9 dimethylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of histone lysine H3 K9 dimethylation" EXACT [GOC:TermGenie]
synonym: "upregulation of histone H3 K9 dimethylation" EXACT [GOC:TermGenie]
synonym: "upregulation of histone H3-K9 dimethylation" EXACT [GOC:TermGenie]
synonym: "upregulation of histone lysine H3 K9 dimethylation" EXACT [GOC:TermGenie]
is_a: GO:0051574 ! positive regulation of histone H3-K9 methylation
is_a: GO:1900109 ! regulation of histone H3-K9 dimethylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0036123 ! histone H3-K9 dimethylation
relationship: positively_regulates GO:0036123 ! histone H3-K9 dimethylation
created_by: bf
creation_date: 2012-02-21T09:06:26Z

[Term]
id: GO:1900112
name: regulation of histone H3-K9 trimethylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of histone H3-K9 trimethylation." [GOC:TermGenie]
is_a: GO:0051570 ! regulation of histone H3-K9 methylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0036124 ! histone H3-K9 trimethylation
relationship: regulates GO:0036124 ! histone H3-K9 trimethylation
created_by: bf
creation_date: 2012-02-21T09:09:49Z

[Term]
id: GO:1900113
name: negative regulation of histone H3-K9 trimethylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K9 trimethylation." [GOC:TermGenie]
synonym: "down regulation of histone H3-K9 trimethylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of histone H3-K9 trimethylation" EXACT [GOC:TermGenie]
synonym: "downregulation of histone H3-K9 trimethylation" EXACT [GOC:TermGenie]
synonym: "inhibition of histone H3-K9 trimethylation" NARROW [GOC:TermGenie]
is_a: GO:0051573 ! negative regulation of histone H3-K9 methylation
is_a: GO:1900112 ! regulation of histone H3-K9 trimethylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0036124 ! histone H3-K9 trimethylation
relationship: negatively_regulates GO:0036124 ! histone H3-K9 trimethylation
created_by: bf
creation_date: 2012-02-21T09:09:54Z

[Term]
id: GO:1900114
name: positive regulation of histone H3-K9 trimethylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of histone H3-K9 trimethylation." [GOC:TermGenie]
synonym: "activation of histone H3-K9 trimethylation" NARROW [GOC:TermGenie]
synonym: "up regulation of histone H3-K9 trimethylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of histone H3-K9 trimethylation" EXACT [GOC:TermGenie]
synonym: "upregulation of histone H3-K9 trimethylation" EXACT [GOC:TermGenie]
is_a: GO:0051574 ! positive regulation of histone H3-K9 methylation
is_a: GO:1900112 ! regulation of histone H3-K9 trimethylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0036124 ! histone H3-K9 trimethylation
relationship: positively_regulates GO:0036124 ! histone H3-K9 trimethylation
created_by: bf
creation_date: 2012-02-21T09:09:58Z

[Term]
id: GO:1900115
name: extracellular regulation of signal transduction
namespace: biological_process
def: "Any regulation of signal transduction that takes place in the extracellular region." [GOC:signaling, GOC:TermGenie]
synonym: "regulation of signaling pathway in extracellular region" EXACT [GOC:TermGenie]
synonym: "regulation of signalling pathway in extracellular region" EXACT [GOC:TermGenie]
is_a: GO:0009966 ! regulation of signal transduction
intersection_of: GO:0009966 ! regulation of signal transduction
intersection_of: occurs_in GO:0005576 ! extracellular region
relationship: occurs_in GO:0005576 ! extracellular region
created_by: bf
creation_date: 2012-02-22T10:21:48Z

[Term]
id: GO:1900116
name: extracellular negative regulation of signal transduction
namespace: biological_process
def: "Any negative regulation of signal transduction that takes place in extracellular region." [GOC:signaling, GOC:TermGenie]
synonym: "down regulation of signal transduction in extracellular region" EXACT [GOC:TermGenie]
synonym: "down-regulation of signal transduction in extracellular region" EXACT [GOC:TermGenie]
synonym: "downregulation of signal transduction in extracellular region" EXACT [GOC:TermGenie]
synonym: "extracellular inhibition of signaling pathway" NARROW [GOC:bf]
synonym: "inhibition of signal transduction in extracellular region" NARROW [GOC:TermGenie]
synonym: "negative regulation of signaling pathway in extracellular region" EXACT [GOC:TermGenie]
synonym: "negative regulation of signalling pathway in extracellular region" EXACT [GOC:TermGenie]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:1900115 ! extracellular regulation of signal transduction
intersection_of: GO:0009968 ! negative regulation of signal transduction
intersection_of: occurs_in GO:0005576 ! extracellular region
relationship: occurs_in GO:0005576 ! extracellular region
created_by: bf
creation_date: 2012-02-22T10:27:56Z

[Term]
id: GO:1900117
name: regulation of execution phase of apoptosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of execution phase of apoptosis." [GOC:mtg_apoptosis, GOC:TermGenie]
is_a: GO:0042981 ! regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097194 ! execution phase of apoptosis
relationship: regulates GO:0097194 ! execution phase of apoptosis
created_by: pr
creation_date: 2012-02-22T11:26:20Z

[Term]
id: GO:1900118
name: negative regulation of execution phase of apoptosis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of execution phase of apoptosis." [GOC:mtg_apoptosis, GOC:TermGenie]
synonym: "down regulation of execution phase of apoptosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of execution phase of apoptosis" EXACT [GOC:TermGenie]
synonym: "downregulation of execution phase of apoptosis" EXACT [GOC:TermGenie]
synonym: "inhibition of execution phase of apoptosis" NARROW [GOC:TermGenie]
is_a: GO:0043066 ! negative regulation of apoptotic process
is_a: GO:1900117 ! regulation of execution phase of apoptosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097194 ! execution phase of apoptosis
relationship: negatively_regulates GO:0097194 ! execution phase of apoptosis
created_by: pr
creation_date: 2012-02-22T11:26:24Z

[Term]
id: GO:1900119
name: positive regulation of execution phase of apoptosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of execution phase of apoptosis." [GOC:mtg_apoptosis, GOC:TermGenie]
synonym: "activation of execution phase of apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of execution phase of apoptosis" EXACT [GOC:TermGenie]
synonym: "up-regulation of execution phase of apoptosis" EXACT [GOC:TermGenie]
synonym: "upregulation of execution phase of apoptosis" EXACT [GOC:TermGenie]
is_a: GO:0043065 ! positive regulation of apoptotic process
is_a: GO:1900117 ! regulation of execution phase of apoptosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097194 ! execution phase of apoptosis
relationship: positively_regulates GO:0097194 ! execution phase of apoptosis
created_by: pr
creation_date: 2012-02-22T11:26:27Z

[Term]
id: GO:1900120
name: regulation of receptor binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a protein or other molecule binding to a receptor." [GOC:signaling, GOC:TermGenie]
synonym: "regulation of receptor ligand" NARROW [GOC:TermGenie]
is_a: GO:0043393 ! regulation of protein binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0005102 ! receptor binding
relationship: regulates GO:0005102 ! receptor binding
created_by: bf
creation_date: 2012-02-22T11:40:53Z

[Term]
id: GO:1900121
name: negative regulation of receptor binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of a protein or other molecule binding to a receptor." [GOC:signaling, GOC:TermGenie]
synonym: "down regulation of receptor binding" EXACT [GOC:TermGenie]
synonym: "down regulation of receptor-associated protein activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of receptor binding" EXACT [GOC:TermGenie]
synonym: "downregulation of receptor binding" EXACT [GOC:TermGenie]
synonym: "inhibition of receptor binding" NARROW [GOC:TermGenie]
synonym: "inhibition of receptor ligand" NARROW [GOC:TermGenie]
is_a: GO:0032091 ! negative regulation of protein binding
is_a: GO:1900120 ! regulation of receptor binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0005102 ! receptor binding
relationship: negatively_regulates GO:0005102 ! receptor binding
created_by: bf
creation_date: 2012-02-22T11:40:57Z

[Term]
id: GO:1900122
name: positive regulation of receptor binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a protein or other molecule binding to a receptor." [GOC:signaling, GOC:TermGenie]
synonym: "activation of receptor binding" NARROW [GOC:TermGenie]
synonym: "up regulation of receptor binding" EXACT [GOC:TermGenie]
synonym: "upregulation of receptor binding" EXACT [GOC:TermGenie]
is_a: GO:0032092 ! positive regulation of protein binding
is_a: GO:1900120 ! regulation of receptor binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0005102 ! receptor binding
relationship: positively_regulates GO:0005102 ! receptor binding
created_by: bf
creation_date: 2012-02-22T11:41:00Z

[Term]
id: GO:1900123
name: regulation of nodal receptor complex assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nodal receptor complex assembly." [GOC:signaling, GOC:TermGenie, PMID:15062104]
synonym: "regulation of ActRIIB.ALK4.EGF-CFC complex formation" EXACT [GOC:TermGenie]
synonym: "regulation of nodal receptor complex formation" EXACT [GOC:TermGenie]
is_a: GO:0043254 ! regulation of protein complex assembly
is_a: GO:1900107 ! regulation of nodal signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0038099 ! nodal receptor complex assembly
relationship: regulates GO:0038099 ! nodal receptor complex assembly
created_by: bf
creation_date: 2012-02-22T04:21:49Z

[Term]
id: GO:1900124
name: negative regulation of nodal receptor complex assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of nodal receptor complex assembly." [GOC:signaling, GOC:TermGenie, PMID:15062104]
synonym: "down regulation of ActRIIB.ALK4.EGF-CFC complex formation" EXACT [GOC:TermGenie]
synonym: "down regulation of nodal receptor complex assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of nodal receptor complex formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of ActRIIB.ALK4.EGF-CFC complex formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of nodal receptor complex assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of nodal receptor complex formation" EXACT [GOC:TermGenie]
synonym: "downregulation of ActRIIB.ALK4.EGF-CFC complex formation" EXACT [GOC:TermGenie]
synonym: "downregulation of nodal receptor complex assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of nodal receptor complex formation" EXACT [GOC:TermGenie]
synonym: "inhibition of ActRIIB.ALK4.EGF-CFC complex formation" NARROW [GOC:TermGenie]
synonym: "inhibition of nodal receptor complex assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of nodal receptor complex formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of ActRIIB.ALK4.EGF-CFC complex formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of nodal receptor complex formation" EXACT [GOC:TermGenie]
is_a: GO:0031333 ! negative regulation of protein complex assembly
is_a: GO:1900108 ! negative regulation of nodal signaling pathway
is_a: GO:1900123 ! regulation of nodal receptor complex assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0038099 ! nodal receptor complex assembly
relationship: negatively_regulates GO:0038099 ! nodal receptor complex assembly
created_by: bf
creation_date: 2012-02-22T04:21:53Z

[Term]
id: GO:1900125
name: regulation of hyaluronan biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hyaluronan biosynthetic process." [GOC:TermGenie, GOC:yaf]
synonym: "regulation of hyaluronan anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of hyaluronan formation" EXACT [GOC:TermGenie]
synonym: "regulation of hyaluronan synthesis" EXACT [GOC:TermGenie]
is_a: GO:0032885 ! regulation of polysaccharide biosynthetic process
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030213 ! hyaluronan biosynthetic process
relationship: regulates GO:0030213 ! hyaluronan biosynthetic process
created_by: yaf
creation_date: 2012-02-23T01:09:21Z

[Term]
id: GO:1900126
name: negative regulation of hyaluronan biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hyaluronan biosynthetic process." [GOC:TermGenie, GOC:yaf]
synonym: "down regulation of hyaluronan anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of hyaluronan formation" EXACT [GOC:TermGenie]
synonym: "down regulation of hyaluronan synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of hyaluronan anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of hyaluronan formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of hyaluronan synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of hyaluronan anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of hyaluronan formation" EXACT [GOC:TermGenie]
synonym: "downregulation of hyaluronan synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of hyaluronan anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of hyaluronan biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of hyaluronan biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of hyaluronan formation" EXACT [GOC:TermGenie]
synonym: "inhibition of hyaluronan synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of hyaluronan anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of hyaluronan formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of hyaluronan synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process
is_a: GO:1900125 ! regulation of hyaluronan biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030213 ! hyaluronan biosynthetic process
relationship: negatively_regulates GO:0030213 ! hyaluronan biosynthetic process
created_by: yaf
creation_date: 2012-02-23T01:09:29Z

[Term]
id: GO:1900127
name: positive regulation of hyaluronan biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hyaluronan biosynthetic process." [GOC:TermGenie, GOC:yaf]
synonym: "activation of hyaluronan anabolism" EXACT [GOC:TermGenie]
synonym: "activation of hyaluronan biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of hyaluronan biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of hyaluronan formation" EXACT [GOC:TermGenie]
synonym: "activation of hyaluronan synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of hyaluronan anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of hyaluronan formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of hyaluronan synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of hyaluronan anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of hyaluronan formation" EXACT [GOC:TermGenie]
synonym: "up regulation of hyaluronan synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of hyaluronan anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of hyaluronan formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of hyaluronan synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of hyaluronan anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of hyaluronan formation" EXACT [GOC:TermGenie]
synonym: "upregulation of hyaluronan synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process
is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process
is_a: GO:1900125 ! regulation of hyaluronan biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030213 ! hyaluronan biosynthetic process
relationship: positively_regulates GO:0030213 ! hyaluronan biosynthetic process
created_by: yaf
creation_date: 2012-02-23T01:09:33Z

[Term]
id: GO:1900128
name: regulation of G-protein activated inward rectifier potassium channel activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of G-protein activated inward rectifier potassium channel activity." [GOC:TermGenie]
synonym: "regulation of G protein activated inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "regulation of G protein enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "regulation of G-protein enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "regulation of G-protein-activated inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "regulation of G-protein-enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
is_a: GO:1901979 ! regulation of inward rectifier potassium channel activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0015467 ! G-protein activated inward rectifier potassium channel activity
relationship: regulates GO:0015467 ! G-protein activated inward rectifier potassium channel activity
created_by: bf
creation_date: 2012-02-23T03:12:53Z

[Term]
id: GO:1900129
name: positive regulation of G-protein activated inward rectifier potassium channel activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of G-protein activated inward rectifier potassium channel activity." [GOC:TermGenie]
synonym: "activation of G protein activated inward rectifier potassium channel activity" NARROW [GOC:TermGenie]
synonym: "activation of G protein enhanced inward rectifier potassium channel activity" NARROW [GOC:TermGenie]
synonym: "activation of G-protein activated inward rectifier potassium channel activity" NARROW [GOC:TermGenie]
synonym: "activation of G-protein enhanced inward rectifier potassium channel activity" NARROW [GOC:TermGenie]
synonym: "activation of G-protein-activated inward rectifier potassium channel activity" NARROW [GOC:TermGenie]
synonym: "activation of G-protein-enhanced inward rectifier potassium channel activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of G protein activated inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of G protein enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of G-protein enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of G-protein-activated inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of G-protein-enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of G protein activated inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of G protein enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of G-protein activated inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of G-protein enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of G-protein-activated inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of G-protein-enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of G protein activated inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of G protein enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of G-protein activated inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of G-protein enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of G-protein-activated inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of G-protein-enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of G protein activated inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of G protein enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of G-protein activated inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of G-protein enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of G-protein-activated inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of G-protein-enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
is_a: GO:1900128 ! regulation of G-protein activated inward rectifier potassium channel activity
is_a: GO:1901980 ! positive regulation of inward rectifier potassium channel activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0015467 ! G-protein activated inward rectifier potassium channel activity
relationship: positively_regulates GO:0015467 ! G-protein activated inward rectifier potassium channel activity
created_by: bf
creation_date: 2012-02-23T03:12:58Z

[Term]
id: GO:1900130
name: regulation of lipid binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lipid binding." [GOC:pm, GOC:TermGenie]
is_a: GO:0051098 ! regulation of binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008289 ! lipid binding
relationship: regulates GO:0008289 ! lipid binding
created_by: pm
creation_date: 2012-02-23T04:05:03Z

[Term]
id: GO:1900131
name: negative regulation of lipid binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lipid binding." [GOC:pm, GOC:TermGenie]
synonym: "down regulation of lipid binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of lipid binding" EXACT [GOC:TermGenie]
synonym: "downregulation of lipid binding" EXACT [GOC:TermGenie]
synonym: "inhibition of lipid binding" NARROW [GOC:TermGenie]
is_a: GO:0051100 ! negative regulation of binding
is_a: GO:1900130 ! regulation of lipid binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008289 ! lipid binding
relationship: negatively_regulates GO:0008289 ! lipid binding
created_by: pm
creation_date: 2012-02-23T04:05:07Z

[Term]
id: GO:1900132
name: positive regulation of lipid binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lipid binding." [GOC:pm, GOC:TermGenie]
synonym: "activation of lipid binding" NARROW [GOC:TermGenie]
synonym: "up regulation of lipid binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of lipid binding" EXACT [GOC:TermGenie]
synonym: "upregulation of lipid binding" EXACT [GOC:TermGenie]
is_a: GO:0051099 ! positive regulation of binding
is_a: GO:1900130 ! regulation of lipid binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008289 ! lipid binding
relationship: positively_regulates GO:0008289 ! lipid binding
created_by: pm
creation_date: 2012-02-23T04:05:11Z

[Term]
id: GO:1900133
name: regulation of renin secretion into blood stream
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of renin secretion into blood stream." [GOC:TermGenie]
synonym: "regulation of renin release into blood stream" EXACT [GOC:TermGenie]
is_a: GO:0003073 ! regulation of systemic arterial blood pressure
is_a: GO:0044060 ! regulation of endocrine process
is_a: GO:0050708 ! regulation of protein secretion
is_a: GO:0098801 ! regulation of renal system process
is_a: GO:1903522 ! regulation of blood circulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002001 ! renin secretion into blood stream
relationship: regulates GO:0002001 ! renin secretion into blood stream
created_by: rph
creation_date: 2012-02-27T10:32:01Z

[Term]
id: GO:1900134
name: negative regulation of renin secretion into blood stream
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of renin secretion into blood stream." [GOC:TermGenie]
synonym: "down regulation of renin release into blood stream" EXACT [GOC:TermGenie]
synonym: "down regulation of renin secretion into blood stream" EXACT [GOC:TermGenie]
synonym: "down-regulation of renin release into blood stream" EXACT [GOC:TermGenie]
synonym: "down-regulation of renin secretion into blood stream" EXACT [GOC:TermGenie]
synonym: "downregulation of renin release into blood stream" EXACT [GOC:TermGenie]
synonym: "downregulation of renin secretion into blood stream" EXACT [GOC:TermGenie]
synonym: "inhibition of renin release into blood stream" NARROW [GOC:TermGenie]
synonym: "inhibition of renin secretion into blood stream" NARROW [GOC:TermGenie]
synonym: "negative regulation of renin release into blood stream" EXACT [GOC:TermGenie]
is_a: GO:0050709 ! negative regulation of protein secretion
is_a: GO:1900133 ! regulation of renin secretion into blood stream
is_a: GO:1903523 ! negative regulation of blood circulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002001 ! renin secretion into blood stream
relationship: negatively_regulates GO:0002001 ! renin secretion into blood stream
created_by: rph
creation_date: 2012-02-27T10:32:05Z

[Term]
id: GO:1900135
name: positive regulation of renin secretion into blood stream
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of renin secretion into blood stream." [GOC:TermGenie]
synonym: "activation of renin release into blood stream" NARROW [GOC:TermGenie]
synonym: "activation of renin secretion into blood stream" NARROW [GOC:TermGenie]
synonym: "positive regulation of renin release into blood stream" EXACT [GOC:TermGenie]
synonym: "up regulation of renin release into blood stream" EXACT [GOC:TermGenie]
synonym: "up regulation of renin secretion into blood stream" EXACT [GOC:TermGenie]
synonym: "up-regulation of renin release into blood stream" EXACT [GOC:TermGenie]
synonym: "up-regulation of renin secretion into blood stream" EXACT [GOC:TermGenie]
synonym: "upregulation of renin release into blood stream" EXACT [GOC:TermGenie]
synonym: "upregulation of renin secretion into blood stream" EXACT [GOC:TermGenie]
is_a: GO:0050714 ! positive regulation of protein secretion
is_a: GO:1900133 ! regulation of renin secretion into blood stream
is_a: GO:1903524 ! positive regulation of blood circulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002001 ! renin secretion into blood stream
relationship: positively_regulates GO:0002001 ! renin secretion into blood stream
created_by: rph
creation_date: 2012-02-27T10:32:08Z

[Term]
id: GO:1900136
name: regulation of chemokine activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chemokine activity." [GOC:TermGenie]
is_a: GO:0030334 ! regulation of cell migration
is_a: GO:0050920 ! regulation of chemotaxis
is_a: GO:0060300 ! regulation of cytokine activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008009 ! chemokine activity
relationship: regulates GO:0008009 ! chemokine activity
created_by: bf
creation_date: 2012-02-28T01:36:29Z

[Term]
id: GO:1900137
name: negative regulation of chemokine activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chemokine activity." [GOC:TermGenie]
synonym: "down regulation of chemokine activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of chemokine activity" EXACT [GOC:TermGenie]
synonym: "downregulation of chemokine activity" EXACT [GOC:TermGenie]
synonym: "inhibition of chemokine activity" NARROW [GOC:TermGenie]
is_a: GO:0030336 ! negative regulation of cell migration
is_a: GO:0050922 ! negative regulation of chemotaxis
is_a: GO:0060302 ! negative regulation of cytokine activity
is_a: GO:1900136 ! regulation of chemokine activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008009 ! chemokine activity
relationship: negatively_regulates GO:0008009 ! chemokine activity
created_by: bf
creation_date: 2012-02-28T01:36:33Z

[Term]
id: GO:1900138
name: negative regulation of phospholipase A2 activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of phospholipase A2 activity." [GOC:TermGenie]
synonym: "down regulation of cytosolic phospholipase A2 activity" NARROW [GOC:TermGenie]
synonym: "down regulation of lecithinase A activity" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphatidase activity" RELATED [GOC:TermGenie]
synonym: "down regulation of phosphatidolipase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphatidylcholine 2-acylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of phospholipase A" RELATED [GOC:TermGenie]
synonym: "down regulation of phospholipase A2 activity" EXACT [GOC:TermGenie]
synonym: "down regulation of secreted phospholipase A2 activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of cytosolic phospholipase A2 activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of lecithinase A activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphatidase activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of phosphatidolipase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphatidylcholine 2-acylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of phospholipase A" RELATED [GOC:TermGenie]
synonym: "down-regulation of phospholipase A2 activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of secreted phospholipase A2 activity" NARROW [GOC:TermGenie]
synonym: "downregulation of cytosolic phospholipase A2 activity" NARROW [GOC:TermGenie]
synonym: "downregulation of lecithinase A activity" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphatidase activity" RELATED [GOC:TermGenie]
synonym: "downregulation of phosphatidolipase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphatidylcholine 2-acylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of phospholipase A" RELATED [GOC:TermGenie]
synonym: "downregulation of phospholipase A2 activity" EXACT [GOC:TermGenie]
synonym: "downregulation of secreted phospholipase A2 activity" NARROW [GOC:TermGenie]
synonym: "inhibition of cytosolic phospholipase A2 activity" NARROW [GOC:TermGenie]
synonym: "inhibition of lecithinase A activity" NARROW [GOC:TermGenie]
synonym: "inhibition of phosphatidase activity" RELATED [GOC:TermGenie]
synonym: "inhibition of phosphatidolipase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of phosphatidylcholine 2-acylhydrolase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of phospholipase A" RELATED [GOC:TermGenie]
synonym: "inhibition of phospholipase A2 activity" NARROW [GOC:TermGenie]
synonym: "inhibition of secreted phospholipase A2 activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of cytosolic phospholipase A2 activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of lecithinase A activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphatidase activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of phosphatidolipase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphatidylcholine 2-acylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of phospholipase A" RELATED [GOC:TermGenie]
synonym: "negative regulation of secreted phospholipase A2 activity" NARROW [GOC:TermGenie]
is_a: GO:0010519 ! negative regulation of phospholipase activity
is_a: GO:0032429 ! regulation of phospholipase A2 activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004623 ! phospholipase A2 activity
relationship: negatively_regulates GO:0004623 ! phospholipase A2 activity
created_by: rph
creation_date: 2012-03-01T09:18:24Z

[Term]
id: GO:1900139
name: negative regulation of arachidonic acid secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of arachidonic acid secretion." [GOC:TermGenie]
synonym: "down regulation of arachidonic acid secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of arachidonic acid secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of arachidonic acid secretion" EXACT [GOC:TermGenie]
synonym: "inhibition of arachidonic acid secretion" NARROW [GOC:TermGenie]
is_a: GO:0032304 ! negative regulation of icosanoid secretion
is_a: GO:0090237 ! regulation of arachidonic acid secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0050482 ! arachidonic acid secretion
relationship: negatively_regulates GO:0050482 ! arachidonic acid secretion
created_by: rph
creation_date: 2012-03-01T09:21:19Z

[Term]
id: GO:1900140
name: regulation of seedling development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of seedling development." [GOC:TermGenie]
is_a: GO:0048580 ! regulation of post-embryonic development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0090351 ! seedling development
relationship: regulates GO:0090351 ! seedling development
created_by: dhl
creation_date: 2012-03-01T09:26:07Z

[Term]
id: GO:1900141
name: regulation of oligodendrocyte apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of oligodendrocyte apoptotic process." [GOC:TermGenie, GOC:yaf]
synonym: "regulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie]
is_a: GO:0034350 ! regulation of glial cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097252 ! oligodendrocyte apoptotic process
relationship: regulates GO:0097252 ! oligodendrocyte apoptotic process
created_by: yaf
creation_date: 2012-03-06T10:22:45Z

[Term]
id: GO:1900142
name: negative regulation of oligodendrocyte apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of oligodendrocyte apoptotic process." [GOC:TermGenie, GOC:yaf]
synonym: "down regulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of oligodendrocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of oligodendrocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of oligodendrocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "inhibition of oligodendrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of oligodendrocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie]
is_a: GO:0034351 ! negative regulation of glial cell apoptotic process
is_a: GO:1900141 ! regulation of oligodendrocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097252 ! oligodendrocyte apoptotic process
relationship: negatively_regulates GO:0097252 ! oligodendrocyte apoptotic process
created_by: yaf
creation_date: 2012-03-06T10:22:50Z

[Term]
id: GO:1900143
name: positive regulation of oligodendrocyte apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of oligodendrocyte apoptotic process." [GOC:TermGenie, GOC:yaf]
synonym: "activation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of oligodendrocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of oligodendrocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of oligodendrocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of oligodendrocyte apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0034352 ! positive regulation of glial cell apoptotic process
is_a: GO:1900141 ! regulation of oligodendrocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097252 ! oligodendrocyte apoptotic process
relationship: positively_regulates GO:0097252 ! oligodendrocyte apoptotic process
created_by: yaf
creation_date: 2012-03-06T10:22:54Z

[Term]
id: GO:1900144
name: positive regulation of BMP secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of BMP secretion." [GOC:sart, GOC:TermGenie]
synonym: "activation of BMP protein secretion" NARROW [GOC:TermGenie]
synonym: "activation of BMP secretion" NARROW [GOC:TermGenie]
synonym: "activation of bone morphogenetic protein secretion" NARROW [GOC:TermGenie]
synonym: "positive regulation of BMP protein secretion" EXACT [GOC:TermGenie]
synonym: "positive regulation of bone morphogenetic protein secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of BMP protein secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of BMP secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of bone morphogenetic protein secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of BMP protein secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of BMP secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of bone morphogenetic protein secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of BMP protein secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of BMP secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of bone morphogenetic protein secretion" EXACT [GOC:TermGenie]
is_a: GO:0010647 ! positive regulation of cell communication
is_a: GO:0023056 ! positive regulation of signaling
is_a: GO:0050714 ! positive regulation of protein secretion
is_a: GO:2001284 ! regulation of BMP secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0038055 ! BMP secretion
relationship: positively_regulates GO:0038055 ! BMP secretion
created_by: sart
creation_date: 2012-03-06T10:31:47Z

[Term]
id: GO:1900145
name: regulation of nodal signaling pathway involved in determination of left/right asymmetry
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a nodal signaling pathway, where the nodal signaling pathway is involved in determination of left/right asymmetry." [GOC:BHF, GOC:signaling, GOC:TermGenie, GOC:vk]
synonym: "regulation of nodal signalling pathway involved in determination of left/right asymmetry" EXACT [GOC:mah]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:1900107 ! regulation of nodal signaling pathway
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0038107 ! nodal signaling pathway involved in determination of left/right asymmetry
relationship: regulates GO:0038107 ! nodal signaling pathway involved in determination of left/right asymmetry
created_by: bf
creation_date: 2012-03-06T11:00:32Z

[Term]
id: GO:1900146
name: negative regulation of nodal signaling pathway involved in determination of left/right asymmetry
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of a nodal signaling pathway, where the nodal signaling pathway is involved in determination of left/right asymmetry." [GOC:BHF, GOC:signaling, GOC:TermGenie, GOC:vk]
synonym: "down regulation of nodal signaling pathway involved in determination of left/right asymmetry" EXACT [GOC:TermGenie]
synonym: "down-regulation of nodal signaling pathway involved in determination of left/right asymmetry" EXACT [GOC:TermGenie]
synonym: "downregulation of nodal signaling pathway involved in determination of left/right asymmetry" EXACT [GOC:TermGenie]
synonym: "inhibition of nodal signaling pathway involved in determination of left/right asymmetry" NARROW [GOC:TermGenie]
synonym: "negative regulation of nodal signalling pathway involved in determination of left/right asymmetry" EXACT [GOC:mah]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1900108 ! negative regulation of nodal signaling pathway
is_a: GO:1900145 ! regulation of nodal signaling pathway involved in determination of left/right asymmetry
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0038107 ! nodal signaling pathway involved in determination of left/right asymmetry
relationship: negatively_regulates GO:0038107 ! nodal signaling pathway involved in determination of left/right asymmetry
created_by: bf
creation_date: 2012-03-06T11:00:36Z

[Term]
id: GO:1900147
name: regulation of Schwann cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Schwann cell migration." [GOC:sjw, GOC:TermGenie]
is_a: GO:1903975 ! regulation of glial cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0036135 ! Schwann cell migration
relationship: regulates GO:0036135 ! Schwann cell migration
created_by: bf
creation_date: 2012-03-06T04:14:50Z

[Term]
id: GO:1900148
name: negative regulation of Schwann cell migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of Schwann cell migration." [GOC:sjw, GOC:TermGenie]
synonym: "down regulation of Schwann cell migration" EXACT [GOC:TermGenie]
synonym: "down-regulation of Schwann cell migration" EXACT [GOC:TermGenie]
synonym: "downregulation of Schwann cell migration" EXACT [GOC:TermGenie]
synonym: "inhibition of Schwann cell migration" NARROW [GOC:TermGenie]
is_a: GO:1900147 ! regulation of Schwann cell migration
is_a: GO:1903976 ! negative regulation of glial cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0036135 ! Schwann cell migration
relationship: negatively_regulates GO:0036135 ! Schwann cell migration
created_by: bf
creation_date: 2012-03-06T04:14:55Z

[Term]
id: GO:1900149
name: positive regulation of Schwann cell migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of Schwann cell migration." [GOC:sjw, GOC:TermGenie]
synonym: "activation of Schwann cell migration" NARROW [GOC:TermGenie]
synonym: "up regulation of Schwann cell migration" EXACT [GOC:TermGenie]
synonym: "up-regulation of Schwann cell migration" EXACT [GOC:TermGenie]
synonym: "upregulation of Schwann cell migration" EXACT [GOC:TermGenie]
is_a: GO:1900147 ! regulation of Schwann cell migration
is_a: GO:1903977 ! positive regulation of glial cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0036135 ! Schwann cell migration
relationship: positively_regulates GO:0036135 ! Schwann cell migration
created_by: bf
creation_date: 2012-03-06T04:14:58Z

[Term]
id: GO:1900150
name: regulation of defense response to fungus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of defense response to fungus." [GOC:dhl, GOC:TermGenie, PMID:22242006]
synonym: "regulation of defence response to fungi" EXACT [GOC:TermGenie]
synonym: "regulation of defence response to fungus" EXACT [GOC:TermGenie]
synonym: "regulation of defense response to fungi" EXACT [GOC:TermGenie]
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0032101 ! regulation of response to external stimulus
is_a: GO:0043900 ! regulation of multi-organism process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050832 ! defense response to fungus
relationship: regulates GO:0050832 ! defense response to fungus
created_by: dhl
creation_date: 2012-03-06T10:00:16Z

[Term]
id: GO:1900151
name: regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay." [GOC:mcc, GOC:TermGenie]
synonym: "regulation of deadenylation-dependent mRNA decay" EXACT [GOC:TermGenie]
synonym: "regulation of mRNA breakdown, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "regulation of mRNA catabolic process, deadenylation-dependent" EXACT [GOC:TermGenie]
synonym: "regulation of mRNA catabolic process, deadenylylation-dependent" EXACT [GOC:TermGenie]
synonym: "regulation of mRNA catabolism, deadenylation-dependent" EXACT [GOC:TermGenie]
synonym: "regulation of mRNA catabolism, deadenylylation-dependent" EXACT [GOC:TermGenie]
synonym: "regulation of mRNA degradation, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "regulation of nuclear mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie]
is_a: GO:0061013 ! regulation of mRNA catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000288 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
relationship: regulates GO:0000288 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
created_by: bf
creation_date: 2012-03-07T09:14:43Z

[Term]
id: GO:1900152
name: negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay." [GOC:mcc, GOC:TermGenie]
synonym: "down regulation of deadenylation-dependent mRNA decay" EXACT [GOC:TermGenie]
synonym: "down regulation of mRNA breakdown, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "down regulation of mRNA catabolic process, deadenylation-dependent" EXACT [GOC:TermGenie]
synonym: "down regulation of mRNA catabolic process, deadenylylation-dependent" EXACT [GOC:TermGenie]
synonym: "down regulation of mRNA catabolism, deadenylation-dependent" EXACT [GOC:TermGenie]
synonym: "down regulation of mRNA catabolism, deadenylylation-dependent" EXACT [GOC:TermGenie]
synonym: "down regulation of mRNA degradation, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "down regulation of nuclear mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "down regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "down-regulation of deadenylation-dependent mRNA decay" EXACT [GOC:TermGenie]
synonym: "down-regulation of mRNA breakdown, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "down-regulation of mRNA catabolic process, deadenylation-dependent" EXACT [GOC:TermGenie]
synonym: "down-regulation of mRNA catabolic process, deadenylylation-dependent" EXACT [GOC:TermGenie]
synonym: "down-regulation of mRNA catabolism, deadenylation-dependent" EXACT [GOC:TermGenie]
synonym: "down-regulation of mRNA catabolism, deadenylylation-dependent" EXACT [GOC:TermGenie]
synonym: "down-regulation of mRNA degradation, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "down-regulation of nuclear mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "down-regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "downregulation of deadenylation-dependent mRNA decay" EXACT [GOC:TermGenie]
synonym: "downregulation of mRNA breakdown, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "downregulation of mRNA catabolic process, deadenylation-dependent" EXACT [GOC:TermGenie]
synonym: "downregulation of mRNA catabolic process, deadenylylation-dependent" EXACT [GOC:TermGenie]
synonym: "downregulation of mRNA catabolism, deadenylation-dependent" EXACT [GOC:TermGenie]
synonym: "downregulation of mRNA catabolism, deadenylylation-dependent" EXACT [GOC:TermGenie]
synonym: "downregulation of mRNA degradation, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "downregulation of nuclear mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "downregulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "inhibition of deadenylation-dependent mRNA decay" NARROW [GOC:TermGenie]
synonym: "inhibition of mRNA breakdown, deadenylation-dependent decay" NARROW [GOC:TermGenie]
synonym: "inhibition of mRNA catabolic process, deadenylation-dependent" NARROW [GOC:TermGenie]
synonym: "inhibition of mRNA catabolic process, deadenylylation-dependent" NARROW [GOC:TermGenie]
synonym: "inhibition of mRNA catabolism, deadenylation-dependent" NARROW [GOC:TermGenie]
synonym: "inhibition of mRNA catabolism, deadenylylation-dependent" NARROW [GOC:TermGenie]
synonym: "inhibition of mRNA degradation, deadenylation-dependent decay" NARROW [GOC:TermGenie]
synonym: "inhibition of nuclear mRNA catabolic process, deadenylation-dependent decay" NARROW [GOC:TermGenie]
synonym: "inhibition of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" NARROW [GOC:TermGenie]
synonym: "negative regulation of deadenylation-dependent mRNA decay" EXACT [GOC:TermGenie]
synonym: "negative regulation of mRNA breakdown, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "negative regulation of mRNA catabolic process, deadenylation-dependent" EXACT [GOC:TermGenie]
synonym: "negative regulation of mRNA catabolic process, deadenylylation-dependent" EXACT [GOC:TermGenie]
synonym: "negative regulation of mRNA catabolism, deadenylation-dependent" EXACT [GOC:TermGenie]
synonym: "negative regulation of mRNA catabolism, deadenylylation-dependent" EXACT [GOC:TermGenie]
synonym: "negative regulation of mRNA degradation, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "negative regulation of nuclear mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie]
is_a: GO:1900151 ! regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
is_a: GO:1902373 ! negative regulation of mRNA catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000288 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
relationship: negatively_regulates GO:0000288 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
created_by: bf
creation_date: 2012-03-07T09:14:49Z

[Term]
id: GO:1900153
name: positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay." [GOC:mcc, GOC:TermGenie]
synonym: "activation of deadenylation-dependent mRNA decay" NARROW [GOC:TermGenie]
synonym: "activation of mRNA breakdown, deadenylation-dependent decay" NARROW [GOC:TermGenie]
synonym: "activation of mRNA catabolic process, deadenylation-dependent" NARROW [GOC:TermGenie]
synonym: "activation of mRNA catabolic process, deadenylylation-dependent" NARROW [GOC:TermGenie]
synonym: "activation of mRNA catabolism, deadenylation-dependent" NARROW [GOC:TermGenie]
synonym: "activation of mRNA catabolism, deadenylylation-dependent" NARROW [GOC:TermGenie]
synonym: "activation of mRNA degradation, deadenylation-dependent decay" NARROW [GOC:TermGenie]
synonym: "activation of nuclear mRNA catabolic process, deadenylation-dependent decay" NARROW [GOC:TermGenie]
synonym: "activation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" NARROW [GOC:TermGenie]
synonym: "positive regulation of deadenylation-dependent mRNA decay" EXACT [GOC:TermGenie]
synonym: "positive regulation of mRNA breakdown, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "positive regulation of mRNA catabolic process, deadenylation-dependent" EXACT [GOC:TermGenie]
synonym: "positive regulation of mRNA catabolic process, deadenylylation-dependent" EXACT [GOC:TermGenie]
synonym: "positive regulation of mRNA catabolism, deadenylation-dependent" EXACT [GOC:TermGenie]
synonym: "positive regulation of mRNA catabolism, deadenylylation-dependent" EXACT [GOC:TermGenie]
synonym: "positive regulation of mRNA degradation, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "positive regulation of nuclear mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "up regulation of deadenylation-dependent mRNA decay" EXACT [GOC:TermGenie]
synonym: "up regulation of mRNA breakdown, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "up regulation of mRNA catabolic process, deadenylation-dependent" EXACT [GOC:TermGenie]
synonym: "up regulation of mRNA catabolic process, deadenylylation-dependent" EXACT [GOC:TermGenie]
synonym: "up regulation of mRNA catabolism, deadenylation-dependent" EXACT [GOC:TermGenie]
synonym: "up regulation of mRNA catabolism, deadenylylation-dependent" EXACT [GOC:TermGenie]
synonym: "up regulation of mRNA degradation, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "up regulation of nuclear mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "up regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "up-regulation of deadenylation-dependent mRNA decay" EXACT [GOC:TermGenie]
synonym: "up-regulation of mRNA breakdown, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "up-regulation of mRNA catabolic process, deadenylation-dependent" EXACT [GOC:TermGenie]
synonym: "up-regulation of mRNA catabolic process, deadenylylation-dependent" EXACT [GOC:TermGenie]
synonym: "up-regulation of mRNA catabolism, deadenylation-dependent" EXACT [GOC:TermGenie]
synonym: "up-regulation of mRNA catabolism, deadenylylation-dependent" EXACT [GOC:TermGenie]
synonym: "up-regulation of mRNA degradation, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "up-regulation of nuclear mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "up-regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "upregulation of deadenylation-dependent mRNA decay" EXACT [GOC:TermGenie]
synonym: "upregulation of mRNA breakdown, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "upregulation of mRNA catabolic process, deadenylation-dependent" EXACT [GOC:TermGenie]
synonym: "upregulation of mRNA catabolic process, deadenylylation-dependent" EXACT [GOC:TermGenie]
synonym: "upregulation of mRNA catabolism, deadenylation-dependent" EXACT [GOC:TermGenie]
synonym: "upregulation of mRNA catabolism, deadenylylation-dependent" EXACT [GOC:TermGenie]
synonym: "upregulation of mRNA degradation, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "upregulation of nuclear mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie]
synonym: "upregulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie]
is_a: GO:0061014 ! positive regulation of mRNA catabolic process
is_a: GO:1900151 ! regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000288 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
relationship: positively_regulates GO:0000288 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
created_by: bf
creation_date: 2012-03-07T09:14:52Z

[Term]
id: GO:1900154
name: regulation of bone trabecula formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of bone trabecula formation." [GOC:BHF, GOC:TermGenie]
synonym: "regulation of bone trabecula biogenesis" RELATED [GOC:TermGenie]
synonym: "regulation of bone trabeculation" EXACT [GOC:TermGenie]
synonym: "regulation of skeletal trabecula biogenesis" RELATED [GOC:TermGenie]
synonym: "regulation of skeletal trabecula formation" EXACT [GOC:TermGenie]
synonym: "regulation of skeletal trabeculation" EXACT [GOC:TermGenie]
is_a: GO:2000027 ! regulation of organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060346 ! bone trabecula formation
relationship: regulates GO:0060346 ! bone trabecula formation
created_by: vk
creation_date: 2012-03-07T01:47:03Z

[Term]
id: GO:1900155
name: negative regulation of bone trabecula formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of bone trabecula formation." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of bone trabecula biogenesis" RELATED [GOC:TermGenie]
synonym: "down regulation of bone trabecula formation" EXACT [GOC:TermGenie]
synonym: "down regulation of bone trabeculation" EXACT [GOC:TermGenie]
synonym: "down regulation of skeletal trabecula biogenesis" RELATED [GOC:TermGenie]
synonym: "down regulation of skeletal trabecula formation" EXACT [GOC:TermGenie]
synonym: "down regulation of skeletal trabeculation" EXACT [GOC:TermGenie]
synonym: "down-regulation of bone trabecula biogenesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of bone trabecula formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of bone trabeculation" EXACT [GOC:TermGenie]
synonym: "down-regulation of skeletal trabecula biogenesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of skeletal trabecula formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of skeletal trabeculation" EXACT [GOC:TermGenie]
synonym: "downregulation of bone trabecula biogenesis" RELATED [GOC:TermGenie]
synonym: "downregulation of bone trabecula formation" EXACT [GOC:TermGenie]
synonym: "downregulation of bone trabeculation" EXACT [GOC:TermGenie]
synonym: "downregulation of skeletal trabecula biogenesis" RELATED [GOC:TermGenie]
synonym: "downregulation of skeletal trabecula formation" EXACT [GOC:TermGenie]
synonym: "downregulation of skeletal trabeculation" EXACT [GOC:TermGenie]
synonym: "inhibition of bone trabecula biogenesis" RELATED [GOC:TermGenie]
synonym: "inhibition of bone trabecula formation" NARROW [GOC:TermGenie]
synonym: "inhibition of bone trabeculation" NARROW [GOC:TermGenie]
synonym: "inhibition of skeletal trabecula biogenesis" RELATED [GOC:TermGenie]
synonym: "inhibition of skeletal trabecula formation" NARROW [GOC:TermGenie]
synonym: "inhibition of skeletal trabeculation" NARROW [GOC:TermGenie]
synonym: "negative regulation of bone trabecula biogenesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of bone trabeculation" EXACT [GOC:TermGenie]
synonym: "negative regulation of skeletal trabecula biogenesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of skeletal trabecula formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of skeletal trabeculation" EXACT [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1900154 ! regulation of bone trabecula formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060346 ! bone trabecula formation
relationship: negatively_regulates GO:0060346 ! bone trabecula formation
created_by: vk
creation_date: 2012-03-07T01:47:07Z

[Term]
id: GO:1900156
name: positive regulation of bone trabecula formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of bone trabecula formation." [GOC:BHF, GOC:TermGenie]
synonym: "activation of bone trabecula biogenesis" RELATED [GOC:TermGenie]
synonym: "activation of bone trabecula formation" NARROW [GOC:TermGenie]
synonym: "activation of bone trabeculation" NARROW [GOC:TermGenie]
synonym: "activation of skeletal trabecula biogenesis" RELATED [GOC:TermGenie]
synonym: "activation of skeletal trabecula formation" NARROW [GOC:TermGenie]
synonym: "activation of skeletal trabeculation" NARROW [GOC:TermGenie]
synonym: "positive regulation of bone trabecula biogenesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of bone trabeculation" EXACT [GOC:TermGenie]
synonym: "positive regulation of skeletal trabecula biogenesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of skeletal trabecula formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of skeletal trabeculation" EXACT [GOC:TermGenie]
synonym: "up regulation of bone trabecula biogenesis" RELATED [GOC:TermGenie]
synonym: "up regulation of bone trabecula formation" EXACT [GOC:TermGenie]
synonym: "up regulation of bone trabeculation" EXACT [GOC:TermGenie]
synonym: "up regulation of skeletal trabecula biogenesis" RELATED [GOC:TermGenie]
synonym: "up regulation of skeletal trabecula formation" EXACT [GOC:TermGenie]
synonym: "up regulation of skeletal trabeculation" EXACT [GOC:TermGenie]
synonym: "up-regulation of bone trabecula biogenesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of bone trabecula formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of bone trabeculation" EXACT [GOC:TermGenie]
synonym: "up-regulation of skeletal trabecula biogenesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of skeletal trabecula formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of skeletal trabeculation" EXACT [GOC:TermGenie]
synonym: "upregulation of bone trabecula biogenesis" RELATED [GOC:TermGenie]
synonym: "upregulation of bone trabecula formation" EXACT [GOC:TermGenie]
synonym: "upregulation of bone trabeculation" EXACT [GOC:TermGenie]
synonym: "upregulation of skeletal trabecula biogenesis" RELATED [GOC:TermGenie]
synonym: "upregulation of skeletal trabecula formation" EXACT [GOC:TermGenie]
synonym: "upregulation of skeletal trabeculation" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1900154 ! regulation of bone trabecula formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060346 ! bone trabecula formation
relationship: positively_regulates GO:0060346 ! bone trabecula formation
created_by: vk
creation_date: 2012-03-07T01:47:10Z

[Term]
id: GO:1900157
name: regulation of bone mineralization involved in bone maturation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of bone mineralization involved in bone maturation." [GOC:BHF, GOC:TermGenie]
is_a: GO:0030500 ! regulation of bone mineralization
is_a: GO:1903010 ! regulation of bone development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035630 ! bone mineralization involved in bone maturation
relationship: regulates GO:0035630 ! bone mineralization involved in bone maturation
created_by: vk
creation_date: 2012-03-07T08:55:07Z

[Term]
id: GO:1900158
name: negative regulation of bone mineralization involved in bone maturation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of bone mineralization involved in bone maturation." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of bone mineralization involved in bone maturation" EXACT [GOC:TermGenie]
synonym: "down-regulation of bone mineralization involved in bone maturation" EXACT [GOC:TermGenie]
synonym: "downregulation of bone mineralization involved in bone maturation" EXACT [GOC:TermGenie]
synonym: "inhibition of bone mineralization involved in bone maturation" NARROW [GOC:TermGenie]
is_a: GO:0030502 ! negative regulation of bone mineralization
is_a: GO:1900157 ! regulation of bone mineralization involved in bone maturation
is_a: GO:1903011 ! negative regulation of bone development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035630 ! bone mineralization involved in bone maturation
relationship: negatively_regulates GO:0035630 ! bone mineralization involved in bone maturation
created_by: vk
creation_date: 2012-03-07T08:55:12Z

[Term]
id: GO:1900159
name: positive regulation of bone mineralization involved in bone maturation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of bone mineralization involved in bone maturation." [GOC:BHF, GOC:TermGenie]
synonym: "activation of bone mineralization involved in bone maturation" NARROW [GOC:TermGenie]
synonym: "up regulation of bone mineralization involved in bone maturation" EXACT [GOC:TermGenie]
synonym: "up-regulation of bone mineralization involved in bone maturation" EXACT [GOC:TermGenie]
synonym: "upregulation of bone mineralization involved in bone maturation" EXACT [GOC:TermGenie]
is_a: GO:0030501 ! positive regulation of bone mineralization
is_a: GO:1900157 ! regulation of bone mineralization involved in bone maturation
is_a: GO:1903012 ! positive regulation of bone development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035630 ! bone mineralization involved in bone maturation
relationship: positively_regulates GO:0035630 ! bone mineralization involved in bone maturation
created_by: vk
creation_date: 2012-03-07T08:55:16Z

[Term]
id: GO:1900160
name: plastid DNA packaging
namespace: biological_process
def: "Any process in which plastidial DNA and associated proteins are formed into a compact, orderly structure." [GOC:emb, GOC:TermGenie, PMID:12081370]
synonym: "DNA organisation in plastid" EXACT [GOC:TermGenie]
synonym: "DNA organization in plastid" EXACT [GOC:TermGenie]
synonym: "plastidial DNA packaging" EXACT [GOC:emb]
is_a: GO:0036385 ! nucleoid DNA packaging
intersection_of: GO:0006323 ! DNA packaging
intersection_of: occurs_in GO:0009536 ! plastid
relationship: occurs_in GO:0009536 ! plastid
created_by: bf
creation_date: 2012-03-08T10:51:50Z

[Term]
id: GO:1900161
name: regulation of phospholipid scramblase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phospholipid scramblase activity." [GOC:TermGenie]
is_a: GO:0032409 ! regulation of transporter activity
is_a: GO:0097035 ! regulation of membrane lipid distribution
is_a: GO:1903729 ! regulation of plasma membrane organization
is_a: GO:2001138 ! regulation of phospholipid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0017128 ! phospholipid scramblase activity
relationship: regulates GO:0017128 ! phospholipid scramblase activity
created_by: rph
creation_date: 2012-03-08T10:57:19Z

[Term]
id: GO:1900162
name: negative regulation of phospholipid scramblase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of phospholipid scramblase activity." [GOC:TermGenie]
synonym: "down regulation of phospholipid scramblase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of phospholipid scramblase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of phospholipid scramblase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of phospholipid scramblase activity" NARROW [GOC:TermGenie]
is_a: GO:0032410 ! negative regulation of transporter activity
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1900161 ! regulation of phospholipid scramblase activity
is_a: GO:2001139 ! negative regulation of phospholipid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0017128 ! phospholipid scramblase activity
relationship: negatively_regulates GO:0017128 ! phospholipid scramblase activity
created_by: rph
creation_date: 2012-03-08T10:57:23Z

[Term]
id: GO:1900163
name: positive regulation of phospholipid scramblase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phospholipid scramblase activity." [GOC:TermGenie]
synonym: "activation of phospholipid scramblase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of phospholipid scramblase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of phospholipid scramblase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of phospholipid scramblase activity" EXACT [GOC:TermGenie]
is_a: GO:0032411 ! positive regulation of transporter activity
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1900161 ! regulation of phospholipid scramblase activity
is_a: GO:2001140 ! positive regulation of phospholipid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0017128 ! phospholipid scramblase activity
relationship: positively_regulates GO:0017128 ! phospholipid scramblase activity
created_by: rph
creation_date: 2012-03-08T10:57:26Z

[Term]
id: GO:1900164
name: nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
namespace: biological_process
def: "A series of molecular signals initiated by the binding of a nodal protein to an activin receptor on the surface of a target cell, which contributes to the establishment of lateral mesoderm with respect to the left and right halves." [GOC:BHF, GOC:TermGenie, GOC:vk]
synonym: "nodal signaling of determination of left/right asymmetry in lateral mesoderm" EXACT [GOC:TermGenie]
synonym: "nodal signaling pathway of determination of left/right asymmetry in lateral mesoderm" EXACT [GOC:TermGenie]
synonym: "nodal signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:mah]
is_a: GO:0038107 ! nodal signaling pathway involved in determination of left/right asymmetry
intersection_of: GO:0038092 ! nodal signaling pathway
intersection_of: part_of GO:0003140 ! determination of left/right asymmetry in lateral mesoderm
relationship: part_of GO:0003140 ! determination of left/right asymmetry in lateral mesoderm
created_by: bf
creation_date: 2012-03-08T02:58:39Z

[Term]
id: GO:1900165
name: negative regulation of interleukin-6 secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-6 secretion." [GOC:TermGenie, GOC:yaf]
synonym: "down regulation of IL-6 secretion" EXACT [GOC:TermGenie]
synonym: "down regulation of interleukin-6 secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of IL-6 secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of interleukin-6 secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of IL-6 secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of interleukin-6 secretion" EXACT [GOC:TermGenie]
synonym: "inhibition of IL-6 secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of interleukin-6 secretion" NARROW [GOC:TermGenie]
synonym: "negative regulation of IL-6 secretion" EXACT [GOC:TermGenie]
is_a: GO:0032715 ! negative regulation of interleukin-6 production
is_a: GO:0050710 ! negative regulation of cytokine secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072604 ! interleukin-6 secretion
relationship: negatively_regulates GO:0072604 ! interleukin-6 secretion
created_by: yaf
creation_date: 2012-03-08T03:27:05Z

[Term]
id: GO:1900166
name: regulation of glial cell-derived neurotrophic factor secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glial cell-derived neurotrophic factor secretion." [GOC:TermGenie, GOC:yaf]
synonym: "regulation of GDNF secretion" EXACT [GOC:TermGenie]
synonym: "regulation of glial cell line-derived neurotrophic factor secretion" RELATED []
is_a: GO:0050707 ! regulation of cytokine secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044467 ! glial cell-derived neurotrophic factor secretion
relationship: regulates GO:0044467 ! glial cell-derived neurotrophic factor secretion
created_by: yaf
creation_date: 2012-03-08T03:44:39Z

[Term]
id: GO:1900167
name: negative regulation of glial cell-derived neurotrophic factor secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glial cell-derived neurotrophic factor secretion." [GOC:TermGenie, GOC:yaf]
synonym: "down regulation of GDNF secretion" EXACT [GOC:TermGenie]
synonym: "down regulation of glial cell line-derived neurotrophic factor secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of GDNF secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of glial cell line-derived neurotrophic factor secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of GDNF secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of glial cell line-derived neurotrophic factor secretion" EXACT [GOC:TermGenie]
synonym: "inhibition of GDNF secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of glial cell line-derived neurotrophic factor secretion" NARROW [GOC:TermGenie]
synonym: "negative regulation of GDNF secretion" EXACT [GOC:TermGenie]
synonym: "negative regulation of glial cell line-derived neurotrophic factor secretion" RELATED []
is_a: GO:0050710 ! negative regulation of cytokine secretion
is_a: GO:1900166 ! regulation of glial cell-derived neurotrophic factor secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044467 ! glial cell-derived neurotrophic factor secretion
relationship: negatively_regulates GO:0044467 ! glial cell-derived neurotrophic factor secretion
created_by: yaf
creation_date: 2012-03-08T03:44:43Z

[Term]
id: GO:1900168
name: positive regulation of glial cell-derived neurotrophic factor secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glial cell-derived neurotrophic factor secretion." [GOC:TermGenie, GOC:yaf]
synonym: "activation of GDNF secretion" NARROW [GOC:TermGenie]
synonym: "activation of glial cell line-derived neurotrophic factor secretion" NARROW [GOC:TermGenie]
synonym: "positive regulation of GDNF secretion" EXACT [GOC:TermGenie]
synonym: "positive regulation of glial cell line-derived neurotrophic factor secretion" RELATED []
synonym: "up regulation of GDNF secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of glial cell line-derived neurotrophic factor secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of GDNF secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of glial cell line-derived neurotrophic factor secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of GDNF secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of glial cell line-derived neurotrophic factor secretion" EXACT [GOC:TermGenie]
is_a: GO:0050715 ! positive regulation of cytokine secretion
is_a: GO:1900166 ! regulation of glial cell-derived neurotrophic factor secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044467 ! glial cell-derived neurotrophic factor secretion
relationship: positively_regulates GO:0044467 ! glial cell-derived neurotrophic factor secretion
created_by: yaf
creation_date: 2012-03-08T03:44:47Z

[Term]
id: GO:1900169
name: regulation of glucocorticoid mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glucocorticoid mediated signaling pathway." [GOC:TermGenie]
synonym: "regulation of glucocorticoid mediated signalling" EXACT [GOC:TermGenie]
is_a: GO:0009966 ! regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043402 ! glucocorticoid mediated signaling pathway
relationship: regulates GO:0043402 ! glucocorticoid mediated signaling pathway
created_by: hjd
creation_date: 2012-03-08T08:33:16Z

[Term]
id: GO:1900170
name: negative regulation of glucocorticoid mediated signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glucocorticoid mediated signaling pathway." [GOC:TermGenie]
synonym: "down regulation of glucocorticoid mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of glucocorticoid mediated signalling" EXACT [GOC:TermGenie]
synonym: "down-regulation of glucocorticoid mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of glucocorticoid mediated signalling" EXACT [GOC:TermGenie]
synonym: "downregulation of glucocorticoid mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of glucocorticoid mediated signalling" EXACT [GOC:TermGenie]
synonym: "inhibition of glucocorticoid mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of glucocorticoid mediated signalling" NARROW [GOC:TermGenie]
synonym: "negative regulation of glucocorticoid mediated signalling" EXACT [GOC:TermGenie]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:1900169 ! regulation of glucocorticoid mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043402 ! glucocorticoid mediated signaling pathway
relationship: negatively_regulates GO:0043402 ! glucocorticoid mediated signaling pathway
created_by: hjd
creation_date: 2012-03-08T08:33:20Z

[Term]
id: GO:1900171
name: positive regulation of glucocorticoid mediated signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glucocorticoid mediated signaling pathway." [GOC:TermGenie]
synonym: "activation of glucocorticoid mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of glucocorticoid mediated signalling" NARROW [GOC:TermGenie]
synonym: "positive regulation of glucocorticoid mediated signalling" EXACT [GOC:TermGenie]
synonym: "up regulation of glucocorticoid mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of glucocorticoid mediated signalling" EXACT [GOC:TermGenie]
synonym: "up-regulation of glucocorticoid mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of glucocorticoid mediated signalling" EXACT [GOC:TermGenie]
synonym: "upregulation of glucocorticoid mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of glucocorticoid mediated signalling" EXACT [GOC:TermGenie]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:1900169 ! regulation of glucocorticoid mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043402 ! glucocorticoid mediated signaling pathway
relationship: positively_regulates GO:0043402 ! glucocorticoid mediated signaling pathway
created_by: hjd
creation_date: 2012-03-08T08:33:23Z

[Term]
id: GO:1900175
name: regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a nodal signaling pathway, where the nodal signaling pathway is involved in determination of left/right asymmetry in the lateral mesoderm." [GOC:BHF, GOC:TermGenie, GOC:vk]
synonym: "regulation of nodal signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:mah]
is_a: GO:1900145 ! regulation of nodal signaling pathway involved in determination of left/right asymmetry
is_a: GO:2000380 ! regulation of mesoderm development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900164 ! nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
relationship: regulates GO:1900164 ! nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
created_by: bf
creation_date: 2012-03-09T10:39:10Z

[Term]
id: GO:1900176
name: negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of a nodal signaling pathway, where the nodal signaling pathway is involved in determination of left/right asymmetry in the lateral mesoderm." [GOC:BHF, GOC:TermGenie, GOC:vk, PMID:15084459]
synonym: "down-regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie]
synonym: "downregulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie]
synonym: "inhibition of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry" NARROW [GOC:TermGenie]
synonym: "negative regulation of nodal signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:mah]
is_a: GO:1900146 ! negative regulation of nodal signaling pathway involved in determination of left/right asymmetry
is_a: GO:1900175 ! regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
is_a: GO:2000381 ! negative regulation of mesoderm development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900164 ! nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
relationship: negatively_regulates GO:1900164 ! nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
created_by: bf
creation_date: 2012-03-09T10:39:14Z

[Term]
id: GO:1900177
name: regulation of aflatoxin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of aflatoxin biosynthetic process." [GOC:di]
synonym: "regulation of aflatoxin anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of aflatoxin biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of aflatoxin formation" EXACT [GOC:TermGenie]
synonym: "regulation of aflatoxin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
is_a: GO:2000762 ! regulation of phenylpropanoid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045122 ! aflatoxin biosynthetic process
relationship: regulates GO:0045122 ! aflatoxin biosynthetic process
created_by: di
creation_date: 2012-03-09T11:23:35Z

[Term]
id: GO:1900178
name: negative regulation of aflatoxin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of aflatoxin biosynthetic process." [GOC:di]
synonym: "down regulation of aflatoxin anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of aflatoxin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of aflatoxin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of aflatoxin formation" EXACT [GOC:TermGenie]
synonym: "down regulation of aflatoxin synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of aflatoxin anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of aflatoxin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of aflatoxin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of aflatoxin formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of aflatoxin synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of aflatoxin anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of aflatoxin biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of aflatoxin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of aflatoxin formation" EXACT [GOC:TermGenie]
synonym: "downregulation of aflatoxin synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of aflatoxin anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of aflatoxin biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of aflatoxin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of aflatoxin formation" NARROW [GOC:TermGenie]
synonym: "inhibition of aflatoxin synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of aflatoxin anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of aflatoxin biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of aflatoxin formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of aflatoxin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:1900177 ! regulation of aflatoxin biosynthetic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045122 ! aflatoxin biosynthetic process
relationship: negatively_regulates GO:0045122 ! aflatoxin biosynthetic process
created_by: di
creation_date: 2012-03-09T11:23:42Z

[Term]
id: GO:1900179
name: positive regulation of aflatoxin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of aflatoxin biosynthetic process." [GOC:di]
synonym: "activation of aflatoxin anabolism" NARROW [GOC:TermGenie]
synonym: "activation of aflatoxin biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of aflatoxin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of aflatoxin formation" NARROW [GOC:TermGenie]
synonym: "activation of aflatoxin synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of aflatoxin anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of aflatoxin biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of aflatoxin formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of aflatoxin synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of aflatoxin anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of aflatoxin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of aflatoxin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of aflatoxin formation" EXACT [GOC:TermGenie]
synonym: "up regulation of aflatoxin synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of aflatoxin anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of aflatoxin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of aflatoxin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of aflatoxin formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of aflatoxin synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of aflatoxin anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of aflatoxin biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of aflatoxin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of aflatoxin formation" EXACT [GOC:TermGenie]
synonym: "upregulation of aflatoxin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:1900177 ! regulation of aflatoxin biosynthetic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045122 ! aflatoxin biosynthetic process
relationship: positively_regulates GO:0045122 ! aflatoxin biosynthetic process
created_by: di
creation_date: 2012-03-09T11:23:46Z

[Term]
id: GO:1900180
name: regulation of protein localization to nucleus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie]
synonym: "regulation of protein localisation to nucleus" EXACT [GOC:TermGenie]
synonym: "regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie]
synonym: "regulation of protein localization in nucleus" EXACT [GOC:TermGenie]
is_a: GO:1903827 ! regulation of cellular protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034504 ! protein localization to nucleus
relationship: regulates GO:0034504 ! protein localization to nucleus
created_by: bf
creation_date: 2012-03-12T01:23:44Z

[Term]
id: GO:1900181
name: negative regulation of protein localization to nucleus
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie]
synonym: "down regulation of protein localisation to nucleus" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization in nucleus" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to nucleus" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation to nucleus" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization in nucleus" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to nucleus" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation to nucleus" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization in cell nucleus" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization in nucleus" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to nucleus" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localisation to nucleus" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization in cell nucleus" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization in nucleus" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to nucleus" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation to nucleus" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localization in nucleus" EXACT [GOC:TermGenie]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:1900180 ! regulation of protein localization to nucleus
is_a: GO:1903828 ! negative regulation of cellular protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034504 ! protein localization to nucleus
relationship: negatively_regulates GO:0034504 ! protein localization to nucleus
created_by: bf
creation_date: 2012-03-12T01:23:48Z

[Term]
id: GO:1900182
name: positive regulation of protein localization to nucleus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie]
synonym: "activation of protein localisation to nucleus" NARROW [GOC:TermGenie]
synonym: "activation of protein localization in cell nucleus" NARROW [GOC:TermGenie]
synonym: "activation of protein localization in nucleus" EXACT [GOC:TermGenie]
synonym: "activation of protein localization to nucleus" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein localisation to nucleus" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localization in nucleus" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation to nucleus" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization in nucleus" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to nucleus" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation to nucleus" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization in nucleus" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to nucleus" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation to nucleus" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization in cell nucleus" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization in nucleus" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to nucleus" EXACT [GOC:TermGenie]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:1900180 ! regulation of protein localization to nucleus
is_a: GO:1903829 ! positive regulation of cellular protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034504 ! protein localization to nucleus
relationship: positively_regulates GO:0034504 ! protein localization to nucleus
created_by: bf
creation_date: 2012-03-12T01:23:52Z

[Term]
id: GO:1900183
name: regulation of xanthone-containing compound biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of xanthone-containing compound biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of xanthone biosynthesis" NARROW [GOC:TermGenie]
synonym: "regulation of xanthone biosynthetic process" NARROW [GOC:TermGenie]
synonym: "regulation of xanthone-containing compound anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of xanthone-containing compound biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of xanthone-containing compound formation" EXACT [GOC:TermGenie]
synonym: "regulation of xanthone-containing compound synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010566 ! regulation of ketone biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:2001307 ! xanthone-containing compound biosynthetic process
relationship: regulates GO:2001307 ! xanthone-containing compound biosynthetic process
created_by: di
creation_date: 2012-03-16T03:30:14Z

[Term]
id: GO:1900184
name: negative regulation of xanthone-containing compound biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of xanthone-containing compound biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of xanthone biosynthesis" NARROW [GOC:TermGenie]
synonym: "down regulation of xanthone biosynthetic process" NARROW [GOC:TermGenie]
synonym: "down regulation of xanthone-containing compound anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of xanthone-containing compound biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of xanthone-containing compound biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of xanthone-containing compound formation" EXACT [GOC:TermGenie]
synonym: "down regulation of xanthone-containing compound synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of xanthone biosynthesis" NARROW [GOC:TermGenie]
synonym: "down-regulation of xanthone biosynthetic process" NARROW [GOC:TermGenie]
synonym: "down-regulation of xanthone-containing compound anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of xanthone-containing compound biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of xanthone-containing compound biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of xanthone-containing compound formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of xanthone-containing compound synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of xanthone biosynthesis" NARROW [GOC:TermGenie]
synonym: "downregulation of xanthone biosynthetic process" NARROW [GOC:TermGenie]
synonym: "downregulation of xanthone-containing compound anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of xanthone-containing compound biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of xanthone-containing compound biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of xanthone-containing compound formation" EXACT [GOC:TermGenie]
synonym: "downregulation of xanthone-containing compound synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of xanthone biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of xanthone biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of xanthone-containing compound anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of xanthone-containing compound biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of xanthone-containing compound biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of xanthone-containing compound formation" EXACT [GOC:TermGenie]
synonym: "inhibition of xanthone-containing compound synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of xanthone biosynthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of xanthone biosynthetic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of xanthone-containing compound anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of xanthone-containing compound biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of xanthone-containing compound formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of xanthone-containing compound synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of xanthones anabolism" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:1900183 ! regulation of xanthone-containing compound biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:2001307 ! xanthone-containing compound biosynthetic process
relationship: negatively_regulates GO:2001307 ! xanthone-containing compound biosynthetic process
created_by: di
creation_date: 2012-03-16T03:30:24Z

[Term]
id: GO:1900185
name: positive regulation of xanthone-containing compound biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of xanthone-containing compound biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of xanthone biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of xanthone biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of xanthone-containing compound anabolism" EXACT [GOC:TermGenie]
synonym: "activation of xanthone-containing compound biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of xanthone-containing compound biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of xanthone-containing compound formation" EXACT [GOC:TermGenie]
synonym: "activation of xanthone-containing compound synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of xanthone biosynthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of xanthone biosynthetic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of xanthone-containing compound anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of xanthone-containing compound biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of xanthone-containing compound formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of xanthone-containing compound synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of xanthone biosynthesis" NARROW [GOC:TermGenie]
synonym: "up regulation of xanthone biosynthetic process" NARROW [GOC:TermGenie]
synonym: "up regulation of xanthone-containing compound anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of xanthone-containing compound biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of xanthone-containing compound biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of xanthone-containing compound formation" EXACT [GOC:TermGenie]
synonym: "up regulation of xanthone-containing compound synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of xanthone biosynthesis" NARROW [GOC:TermGenie]
synonym: "up-regulation of xanthone biosynthetic process" NARROW [GOC:TermGenie]
synonym: "up-regulation of xanthone-containing compound anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of xanthone-containing compound biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of xanthone-containing compound biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of xanthone-containing compound formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of xanthone-containing compound synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of xanthone biosynthesis" NARROW [GOC:TermGenie]
synonym: "upregulation of xanthone biosynthetic process" NARROW [GOC:TermGenie]
synonym: "upregulation of xanthone-containing compound anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of xanthone-containing compound biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of xanthone-containing compound biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of xanthone-containing compound formation" EXACT [GOC:TermGenie]
synonym: "upregulation of xanthone-containing compound synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:1900183 ! regulation of xanthone-containing compound biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:2001307 ! xanthone-containing compound biosynthetic process
relationship: positively_regulates GO:2001307 ! xanthone-containing compound biosynthetic process
created_by: di
creation_date: 2012-03-16T03:30:32Z

[Term]
id: GO:1900186
name: negative regulation of clathrin-mediated endocytosis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of clathrin-mediated endocytosis." [GOC:TermGenie]
synonym: "down regulation of clathrin coated pit-dependent endocytosis" EXACT [GOC:TermGenie]
synonym: "down regulation of clathrin-dependent endocytosis" EXACT [GOC:TermGenie]
synonym: "down regulation of clathrin-mediated endocytosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of clathrin coated pit-dependent endocytosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of clathrin-dependent endocytosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of clathrin-mediated endocytosis" EXACT [GOC:TermGenie]
synonym: "downregulation of clathrin coated pit-dependent endocytosis" EXACT [GOC:TermGenie]
synonym: "downregulation of clathrin-dependent endocytosis" EXACT [GOC:TermGenie]
synonym: "downregulation of clathrin-mediated endocytosis" EXACT [GOC:TermGenie]
synonym: "inhibition of clathrin coated pit-dependent endocytosis" EXACT [GOC:TermGenie]
synonym: "inhibition of clathrin-dependent endocytosis" EXACT [GOC:TermGenie]
synonym: "inhibition of clathrin-mediated endocytosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of clathrin coated pit-dependent endocytosis" EXACT [GOC:TermGenie]
synonym: "negative regulation of clathrin-dependent endocytosis" EXACT [GOC:TermGenie]
is_a: GO:0048261 ! negative regulation of receptor-mediated endocytosis
is_a: GO:2000369 ! regulation of clathrin-mediated endocytosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072583 ! clathrin-mediated endocytosis
relationship: negatively_regulates GO:0072583 ! clathrin-mediated endocytosis
created_by: hjd
creation_date: 2012-03-16T05:25:02Z

[Term]
id: GO:1900187
name: regulation of cell adhesion involved in single-species biofilm formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell adhesion involved in single-species biofilm formation." [GOC:di, GOC:TermGenie]
synonym: "regulation of cell adhesion during single-species biofilm formation" RELATED [GOC:TermGenie]
is_a: GO:0010810 ! regulation of cell-substrate adhesion
is_a: GO:1900190 ! regulation of single-species biofilm formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043709 ! cell adhesion involved in single-species biofilm formation
relationship: regulates GO:0043709 ! cell adhesion involved in single-species biofilm formation
created_by: di
creation_date: 2012-03-19T12:38:45Z

[Term]
id: GO:1900188
name: negative regulation of cell adhesion involved in single-species biofilm formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell adhesion involved in single-species biofilm formation." [GOC:di, GOC:TermGenie]
synonym: "down regulation of cell adhesion during single-species biofilm formation" RELATED [GOC:TermGenie]
synonym: "down regulation of cell adhesion involved in single-species biofilm formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell adhesion during single-species biofilm formation" RELATED [GOC:TermGenie]
synonym: "down-regulation of cell adhesion involved in single-species biofilm formation" EXACT [GOC:TermGenie]
synonym: "downregulation of cell adhesion during single-species biofilm formation" RELATED [GOC:TermGenie]
synonym: "downregulation of cell adhesion involved in single-species biofilm formation" EXACT [GOC:TermGenie]
synonym: "inhibition of cell adhesion during single-species biofilm formation" RELATED [GOC:TermGenie]
synonym: "inhibition of cell adhesion involved in single-species biofilm formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of cell adhesion during single-species biofilm formation" RELATED [GOC:TermGenie]
is_a: GO:0010812 ! negative regulation of cell-substrate adhesion
is_a: GO:1900187 ! regulation of cell adhesion involved in single-species biofilm formation
is_a: GO:1900191 ! negative regulation of single-species biofilm formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043709 ! cell adhesion involved in single-species biofilm formation
relationship: negatively_regulates GO:0043709 ! cell adhesion involved in single-species biofilm formation
created_by: di
creation_date: 2012-03-19T12:38:54Z

[Term]
id: GO:1900189
name: positive regulation of cell adhesion involved in single-species biofilm formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell adhesion involved in single-species biofilm formation." [GOC:di, GOC:TermGenie]
synonym: "activation of cell adhesion during single-species biofilm formation" RELATED [GOC:TermGenie]
synonym: "activation of cell adhesion involved in single-species biofilm formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of cell adhesion during single-species biofilm formation" RELATED [GOC:TermGenie]
synonym: "up regulation of cell adhesion during single-species biofilm formation" RELATED [GOC:TermGenie]
synonym: "up regulation of cell adhesion involved in single-species biofilm formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell adhesion during single-species biofilm formation" RELATED [GOC:TermGenie]
synonym: "up-regulation of cell adhesion involved in single-species biofilm formation" EXACT [GOC:TermGenie]
synonym: "upregulation of cell adhesion during single-species biofilm formation" RELATED [GOC:TermGenie]
synonym: "upregulation of cell adhesion involved in single-species biofilm formation" EXACT [GOC:TermGenie]
is_a: GO:0010811 ! positive regulation of cell-substrate adhesion
is_a: GO:1900187 ! regulation of cell adhesion involved in single-species biofilm formation
is_a: GO:1900192 ! positive regulation of single-species biofilm formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043709 ! cell adhesion involved in single-species biofilm formation
relationship: positively_regulates GO:0043709 ! cell adhesion involved in single-species biofilm formation
created_by: di
creation_date: 2012-03-19T12:39:03Z

[Term]
id: GO:1900190
name: regulation of single-species biofilm formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of single-species biofilm formation." [GOC:di, GOC:TermGenie]
is_a: GO:0043900 ! regulation of multi-organism process
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044010 ! single-species biofilm formation
relationship: regulates GO:0044010 ! single-species biofilm formation
created_by: di
creation_date: 2012-03-19T12:42:04Z

[Term]
id: GO:1900191
name: negative regulation of single-species biofilm formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of single-species biofilm formation." [GOC:di, GOC:TermGenie]
synonym: "down regulation of single-species biofilm formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of single-species biofilm formation" EXACT [GOC:TermGenie]
synonym: "downregulation of single-species biofilm formation" EXACT [GOC:TermGenie]
synonym: "inhibition of single-species biofilm formation" NARROW [GOC:TermGenie]
is_a: GO:0043901 ! negative regulation of multi-organism process
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:1900190 ! regulation of single-species biofilm formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044010 ! single-species biofilm formation
relationship: negatively_regulates GO:0044010 ! single-species biofilm formation
created_by: di
creation_date: 2012-03-19T12:42:13Z

[Term]
id: GO:1900192
name: positive regulation of single-species biofilm formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of single-species biofilm formation." [GOC:di, GOC:TermGenie]
synonym: "activation of single-species biofilm formation" NARROW [GOC:TermGenie]
synonym: "up regulation of single-species biofilm formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of single-species biofilm formation" EXACT [GOC:TermGenie]
synonym: "upregulation of single-species biofilm formation" EXACT [GOC:TermGenie]
is_a: GO:0043902 ! positive regulation of multi-organism process
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:1900190 ! regulation of single-species biofilm formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044010 ! single-species biofilm formation
relationship: positively_regulates GO:0044010 ! single-species biofilm formation
created_by: di
creation_date: 2012-03-19T12:42:21Z

[Term]
id: GO:1900193
name: regulation of oocyte maturation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of oocyte maturation." [GOC:kmv, GOC:TermGenie]
is_a: GO:0060281 ! regulation of oocyte development
is_a: GO:1903429 ! regulation of cell maturation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001556 ! oocyte maturation
relationship: regulates GO:0001556 ! oocyte maturation
created_by: kmv
creation_date: 2012-03-19T09:41:18Z

[Term]
id: GO:1900194
name: negative regulation of oocyte maturation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of oocyte maturation." [GOC:kmv, GOC:TermGenie]
synonym: "down regulation of oocyte maturation" EXACT [GOC:TermGenie]
synonym: "down-regulation of oocyte maturation" EXACT [GOC:TermGenie]
synonym: "downregulation of oocyte maturation" EXACT [GOC:TermGenie]
synonym: "inhibition of oocyte maturation" NARROW [GOC:TermGenie]
is_a: GO:0060283 ! negative regulation of oocyte development
is_a: GO:1900193 ! regulation of oocyte maturation
is_a: GO:1903430 ! negative regulation of cell maturation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001556 ! oocyte maturation
relationship: negatively_regulates GO:0001556 ! oocyte maturation
created_by: kmv
creation_date: 2012-03-19T09:41:27Z

[Term]
id: GO:1900195
name: positive regulation of oocyte maturation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of oocyte maturation." [GOC:kmv, GOC:TermGenie]
synonym: "activation of oocyte maturation" NARROW [GOC:TermGenie]
synonym: "up regulation of oocyte maturation" EXACT [GOC:TermGenie]
synonym: "up-regulation of oocyte maturation" EXACT [GOC:TermGenie]
synonym: "upregulation of oocyte maturation" EXACT [GOC:TermGenie]
is_a: GO:0060282 ! positive regulation of oocyte development
is_a: GO:1900193 ! regulation of oocyte maturation
is_a: GO:1903431 ! positive regulation of cell maturation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001556 ! oocyte maturation
relationship: positively_regulates GO:0001556 ! oocyte maturation
created_by: kmv
creation_date: 2012-03-19T09:41:35Z

[Term]
id: GO:1900196
name: regulation of penicillin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of penicillin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of penicillin anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of penicillin biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of penicillin formation" EXACT [GOC:TermGenie]
synonym: "regulation of penicillin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0033244 ! regulation of penicillin metabolic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042318 ! penicillin biosynthetic process
relationship: regulates GO:0042318 ! penicillin biosynthetic process
created_by: di
creation_date: 2012-03-20T03:56:33Z

[Term]
id: GO:1900197
name: negative regulation of penicillin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of penicillin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of penicillin anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of penicillin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of penicillin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of penicillin formation" EXACT [GOC:TermGenie]
synonym: "down regulation of penicillin synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of penicillin anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of penicillin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of penicillin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of penicillin formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of penicillin synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of penicillin anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of penicillin biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of penicillin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of penicillin formation" EXACT [GOC:TermGenie]
synonym: "downregulation of penicillin synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of penicillin anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of penicillin biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of penicillin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of penicillin formation" EXACT [GOC:TermGenie]
synonym: "inhibition of penicillin synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of penicillin anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of penicillin biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of penicillin formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of penicillin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0033245 ! negative regulation of penicillin metabolic process
is_a: GO:1900196 ! regulation of penicillin biosynthetic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042318 ! penicillin biosynthetic process
relationship: negatively_regulates GO:0042318 ! penicillin biosynthetic process
created_by: di
creation_date: 2012-03-20T03:56:43Z

[Term]
id: GO:1900198
name: positive regulation of penicillin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of penicillin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of penicillin anabolism" EXACT [GOC:TermGenie]
synonym: "activation of penicillin biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of penicillin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of penicillin formation" EXACT [GOC:TermGenie]
synonym: "activation of penicillin synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of penicillin anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of penicillin biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of penicillin formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of penicillin synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of penicillin anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of penicillin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of penicillin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of penicillin formation" EXACT [GOC:TermGenie]
synonym: "up regulation of penicillin synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of penicillin anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of penicillin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of penicillin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of penicillin formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of penicillin synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of penicillin anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of penicillin biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of penicillin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of penicillin formation" EXACT [GOC:TermGenie]
synonym: "upregulation of penicillin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0033246 ! positive regulation of penicillin metabolic process
is_a: GO:1900196 ! regulation of penicillin biosynthetic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042318 ! penicillin biosynthetic process
relationship: positively_regulates GO:0042318 ! penicillin biosynthetic process
created_by: di
creation_date: 2012-03-20T03:56:52Z

[Term]
id: GO:1900199
name: positive regulation of protein export from nucleus during meiotic anaphase II
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm, during anaphase occurring as part of meiosis II." [GOC:al, GOC:TermGenie, PMID:20970342]
synonym: "positive regulation of protein export from nucleus involved in meiotic anaphase II" BROAD [GOC:pr]
is_a: GO:0046827 ! positive regulation of protein export from nucleus
intersection_of: GO:0065007 ! biological regulation
intersection_of: happens_during GO:0007138 ! meiotic anaphase II
intersection_of: positively_regulates GO:0006611 ! protein export from nucleus
relationship: happens_during GO:0007138 ! meiotic anaphase II
relationship: positively_regulates GO:0006611 ! protein export from nucleus
created_by: pr
creation_date: 2012-03-20T06:35:19Z

[Term]
id: GO:1900200
name: mesenchymal cell apoptotic process involved in metanephros development
namespace: biological_process
def: "Any mesenchymal cell apoptotic process that is involved in metanephros development." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325]
synonym: "mesenchymal cell apoptosis involved in metanephros development" NARROW []
is_a: GO:0097152 ! mesenchymal cell apoptotic process
is_a: GO:1902742 ! apoptotic process involved in development
intersection_of: GO:0097152 ! mesenchymal cell apoptotic process
intersection_of: part_of GO:0001656 ! metanephros development
relationship: part_of GO:0001656 ! metanephros development
created_by: yaf
creation_date: 2012-03-21T11:58:05Z

[Term]
id: GO:1900201
name: obsolete regulation of spread of virus in host, cell to cell
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of spread of virus in host, cell to cell." [GOC:TermGenie]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "regulation of cell to cell spread of virus within host" EXACT [GOC:TermGenie]
synonym: "regulation of spread of virus in host, cell to cell" EXACT []
synonym: "regulation of spread of virus within host, cell to cell" EXACT [GOC:TermGenie]
synonym: "regulation of viral spread within host, cell to cell" EXACT [GOC:TermGenie]
is_obsolete: true
created_by: pm
creation_date: 2012-03-21T01:15:41Z

[Term]
id: GO:1900202
name: obsolete negative regulation of spread of virus in host, cell to cell
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of spread of virus in host, cell to cell." [GOC:TermGenie]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "down regulation of cell to cell spread of virus within host" EXACT [GOC:TermGenie]
synonym: "down regulation of spread of virus in host, cell to cell" EXACT [GOC:TermGenie]
synonym: "down regulation of spread of virus within host, cell to cell" EXACT [GOC:TermGenie]
synonym: "down regulation of viral spread within host, cell to cell" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell to cell spread of virus within host" EXACT [GOC:TermGenie]
synonym: "down-regulation of spread of virus in host, cell to cell" EXACT [GOC:TermGenie]
synonym: "down-regulation of spread of virus within host, cell to cell" EXACT [GOC:TermGenie]
synonym: "down-regulation of viral spread within host, cell to cell" EXACT [GOC:TermGenie]
synonym: "downregulation of cell to cell spread of virus within host" EXACT [GOC:TermGenie]
synonym: "downregulation of spread of virus in host, cell to cell" EXACT [GOC:TermGenie]
synonym: "downregulation of spread of virus within host, cell to cell" EXACT [GOC:TermGenie]
synonym: "downregulation of viral spread within host, cell to cell" EXACT [GOC:TermGenie]
synonym: "inhibition of cell to cell spread of virus within host" EXACT [GOC:TermGenie]
synonym: "inhibition of spread of virus in host, cell to cell" NARROW [GOC:TermGenie]
synonym: "inhibition of spread of virus within host, cell to cell" EXACT [GOC:TermGenie]
synonym: "inhibition of viral spread within host, cell to cell" EXACT [GOC:TermGenie]
synonym: "negative regulation of cell to cell spread of virus within host" EXACT [GOC:TermGenie]
synonym: "negative regulation of spread of virus in host, cell to cell" EXACT []
synonym: "negative regulation of spread of virus within host, cell to cell" EXACT [GOC:TermGenie]
synonym: "negative regulation of viral spread within host, cell to cell" EXACT [GOC:TermGenie]
is_obsolete: true
created_by: pm
creation_date: 2012-03-21T01:15:51Z

[Term]
id: GO:1900203
name: obsolete positive regulation of spread of virus in host, cell to cell
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of spread of virus in host, cell to cell." [GOC:TermGenie]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "activation of cell to cell spread of virus within host" EXACT [GOC:TermGenie]
synonym: "activation of spread of virus in host, cell to cell" NARROW [GOC:TermGenie]
synonym: "activation of spread of virus within host, cell to cell" EXACT [GOC:TermGenie]
synonym: "activation of viral spread within host, cell to cell" EXACT [GOC:TermGenie]
synonym: "positive regulation of cell to cell spread of virus within host" EXACT [GOC:TermGenie]
synonym: "positive regulation of spread of virus in host, cell to cell" EXACT []
synonym: "positive regulation of spread of virus within host, cell to cell" EXACT [GOC:TermGenie]
synonym: "positive regulation of viral spread within host, cell to cell" EXACT [GOC:TermGenie]
synonym: "up regulation of cell to cell spread of virus within host" EXACT [GOC:TermGenie]
synonym: "up regulation of spread of virus in host, cell to cell" EXACT [GOC:TermGenie]
synonym: "up regulation of spread of virus within host, cell to cell" EXACT [GOC:TermGenie]
synonym: "up regulation of viral spread within host, cell to cell" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell to cell spread of virus within host" EXACT [GOC:TermGenie]
synonym: "up-regulation of spread of virus in host, cell to cell" EXACT [GOC:TermGenie]
synonym: "up-regulation of spread of virus within host, cell to cell" EXACT [GOC:TermGenie]
synonym: "up-regulation of viral spread within host, cell to cell" EXACT [GOC:TermGenie]
synonym: "upregulation of cell to cell spread of virus within host" EXACT [GOC:TermGenie]
synonym: "upregulation of spread of virus in host, cell to cell" EXACT [GOC:TermGenie]
synonym: "upregulation of spread of virus within host, cell to cell" EXACT [GOC:TermGenie]
synonym: "upregulation of viral spread within host, cell to cell" EXACT [GOC:TermGenie]
is_obsolete: true
created_by: pm
creation_date: 2012-03-21T01:16:00Z

[Term]
id: GO:1900204
name: apoptotic process involved in metanephric collecting duct development
namespace: biological_process
def: "Any apoptotic process that is involved in metanephric collecting duct development." [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325]
synonym: "apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie]
synonym: "type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie]
is_a: GO:1902742 ! apoptotic process involved in development
intersection_of: GO:0006915 ! apoptotic process
intersection_of: part_of GO:0072205 ! metanephric collecting duct development
relationship: part_of GO:0072205 ! metanephric collecting duct development
created_by: yaf
creation_date: 2012-03-21T01:21:32Z

[Term]
id: GO:1900205
name: apoptotic process involved in metanephric nephron tubule development
namespace: biological_process
def: "Any apoptotic process that is involved in metanephric nephron tubule development." [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325]
synonym: "apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie]
synonym: "type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie]
is_a: GO:1902742 ! apoptotic process involved in development
intersection_of: GO:0006915 ! apoptotic process
intersection_of: part_of GO:0072234 ! metanephric nephron tubule development
relationship: part_of GO:0072234 ! metanephric nephron tubule development
created_by: yaf
creation_date: 2012-03-21T01:21:45Z

[Term]
id: GO:1900206
name: regulation of pronephric nephron tubule development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pronephric nephron tubule development." [GOC:TermGenie]
is_a: GO:0090183 ! regulation of kidney development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0039020 ! pronephric nephron tubule development
relationship: regulates GO:0039020 ! pronephric nephron tubule development
created_by: bf
creation_date: 2012-03-22T09:23:13Z

[Term]
id: GO:1900207
name: negative regulation of pronephric nephron tubule development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of pronephric nephron tubule development." [GOC:bf, GOC:TermGenie, PMID:9758706]
synonym: "down regulation of pronephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "down-regulation of pronephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "downregulation of pronephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "inhibition of pronephric nephron tubule development" NARROW [GOC:TermGenie]
is_a: GO:0090185 ! negative regulation of kidney development
is_a: GO:1900206 ! regulation of pronephric nephron tubule development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0039020 ! pronephric nephron tubule development
relationship: negatively_regulates GO:0039020 ! pronephric nephron tubule development
created_by: bf
creation_date: 2012-03-22T09:23:23Z

[Term]
id: GO:1900208
name: regulation of cardiolipin metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiolipin metabolic process." [GOC:TermGenie]
synonym: "regulation of cardiolipin metabolism" EXACT [GOC:TermGenie]
synonym: "regulation of diphosphatidylglycerol metabolic process" RELATED [GOC:TermGenie]
synonym: "regulation of diphosphatidylglycerol metabolism" RELATED [GOC:TermGenie]
is_a: GO:1903725 ! regulation of phospholipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032048 ! cardiolipin metabolic process
relationship: regulates GO:0032048 ! cardiolipin metabolic process
created_by: jl
creation_date: 2012-03-22T10:43:33Z

[Term]
id: GO:1900209
name: negative regulation of cardiolipin metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiolipin metabolic process." [GOC:TermGenie]
synonym: "down regulation of cardiolipin metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of cardiolipin metabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of diphosphatidylglycerol metabolic process" RELATED [GOC:TermGenie]
synonym: "down regulation of diphosphatidylglycerol metabolism" RELATED [GOC:TermGenie]
synonym: "down-regulation of cardiolipin metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of cardiolipin metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of diphosphatidylglycerol metabolic process" RELATED [GOC:TermGenie]
synonym: "down-regulation of diphosphatidylglycerol metabolism" RELATED [GOC:TermGenie]
synonym: "downregulation of cardiolipin metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of cardiolipin metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of diphosphatidylglycerol metabolic process" RELATED [GOC:TermGenie]
synonym: "downregulation of diphosphatidylglycerol metabolism" RELATED [GOC:TermGenie]
synonym: "inhibition of cardiolipin metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of cardiolipin metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of diphosphatidylglycerol metabolic process" RELATED [GOC:TermGenie]
synonym: "inhibition of diphosphatidylglycerol metabolism" RELATED [GOC:TermGenie]
synonym: "negative regulation of cardiolipin metabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of diphosphatidylglycerol metabolic process" RELATED [GOC:TermGenie]
synonym: "negative regulation of diphosphatidylglycerol metabolism" RELATED [GOC:TermGenie]
is_a: GO:1900208 ! regulation of cardiolipin metabolic process
is_a: GO:1903726 ! negative regulation of phospholipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032048 ! cardiolipin metabolic process
relationship: negatively_regulates GO:0032048 ! cardiolipin metabolic process
created_by: jl
creation_date: 2012-03-22T10:43:43Z

[Term]
id: GO:1900210
name: positive regulation of cardiolipin metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiolipin metabolic process." [GOC:TermGenie]
synonym: "activation of cardiolipin metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of cardiolipin metabolism" EXACT [GOC:TermGenie]
synonym: "activation of diphosphatidylglycerol metabolic process" RELATED [GOC:TermGenie]
synonym: "activation of diphosphatidylglycerol metabolism" RELATED [GOC:TermGenie]
synonym: "positive regulation of cardiolipin metabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of diphosphatidylglycerol metabolic process" RELATED [GOC:TermGenie]
synonym: "positive regulation of diphosphatidylglycerol metabolism" RELATED [GOC:TermGenie]
synonym: "up regulation of cardiolipin metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of cardiolipin metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of diphosphatidylglycerol metabolic process" RELATED [GOC:TermGenie]
synonym: "up regulation of diphosphatidylglycerol metabolism" RELATED [GOC:TermGenie]
synonym: "up-regulation of cardiolipin metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of cardiolipin metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of diphosphatidylglycerol metabolic process" RELATED [GOC:TermGenie]
synonym: "up-regulation of diphosphatidylglycerol metabolism" RELATED [GOC:TermGenie]
synonym: "upregulation of cardiolipin metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of cardiolipin metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of diphosphatidylglycerol metabolic process" RELATED [GOC:TermGenie]
synonym: "upregulation of diphosphatidylglycerol metabolism" RELATED [GOC:TermGenie]
is_a: GO:1900208 ! regulation of cardiolipin metabolic process
is_a: GO:1903727 ! positive regulation of phospholipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032048 ! cardiolipin metabolic process
relationship: positively_regulates GO:0032048 ! cardiolipin metabolic process
created_by: jl
creation_date: 2012-03-22T10:43:51Z

[Term]
id: GO:1900211
name: regulation of mesenchymal cell apoptotic process involved in metanephros development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesenchymal cell apoptotic process involved in metanephros development." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325]
synonym: "regulation of mesenchymal cell apoptosis involved in metanephros development" NARROW []
is_a: GO:0072215 ! regulation of metanephros development
is_a: GO:1904748 ! regulation of apoptotic process involved in development
is_a: GO:2001053 ! regulation of mesenchymal cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900200 ! mesenchymal cell apoptotic process involved in metanephros development
relationship: regulates GO:1900200 ! mesenchymal cell apoptotic process involved in metanephros development
created_by: yaf
creation_date: 2012-03-22T10:52:50Z

[Term]
id: GO:1900212
name: negative regulation of mesenchymal cell apoptotic process involved in metanephros development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell apoptotic process involved in metanephros development." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325]
synonym: "down regulation of mesenchymal cell apoptosis involved in metanephros development" EXACT [GOC:TermGenie]
synonym: "down-regulation of mesenchymal cell apoptosis involved in metanephros development" EXACT [GOC:TermGenie]
synonym: "downregulation of mesenchymal cell apoptosis involved in metanephros development" EXACT [GOC:TermGenie]
synonym: "inhibition of mesenchymal cell apoptosis involved in metanephros development" NARROW [GOC:TermGenie]
synonym: "negative regulation of mesenchymal cell apoptosis involved in metanephros development" NARROW []
is_a: GO:0072217 ! negative regulation of metanephros development
is_a: GO:1900211 ! regulation of mesenchymal cell apoptotic process involved in metanephros development
is_a: GO:1904746 ! negative regulation of apoptotic process involved in development
is_a: GO:2001054 ! negative regulation of mesenchymal cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900200 ! mesenchymal cell apoptotic process involved in metanephros development
relationship: negatively_regulates GO:1900200 ! mesenchymal cell apoptotic process involved in metanephros development
created_by: yaf
creation_date: 2012-03-22T10:53:00Z

[Term]
id: GO:1900213
name: positive regulation of mesenchymal cell apoptotic process involved in metanephros development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mesenchymal cell apoptotic process involved in metanephros development." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325]
synonym: "activation of mesenchymal cell apoptosis involved in metanephros development" NARROW [GOC:TermGenie]
synonym: "positive regulation of mesenchymal cell apoptosis involved in metanephros development" NARROW []
synonym: "up regulation of mesenchymal cell apoptosis involved in metanephros development" EXACT [GOC:TermGenie]
synonym: "up-regulation of mesenchymal cell apoptosis involved in metanephros development" EXACT [GOC:TermGenie]
synonym: "upregulation of mesenchymal cell apoptosis involved in metanephros development" EXACT [GOC:TermGenie]
is_a: GO:0072216 ! positive regulation of metanephros development
is_a: GO:1900211 ! regulation of mesenchymal cell apoptotic process involved in metanephros development
is_a: GO:1904747 ! positive regulation of apoptotic process involved in development
is_a: GO:2001055 ! positive regulation of mesenchymal cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900200 ! mesenchymal cell apoptotic process involved in metanephros development
relationship: positively_regulates GO:1900200 ! mesenchymal cell apoptotic process involved in metanephros development
created_by: yaf
creation_date: 2012-03-22T10:53:09Z

[Term]
id: GO:1900214
name: regulation of apoptotic process involved in metanephric collecting duct development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of apoptotic process involved in metanephric collecting duct development." [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325]
synonym: "regulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "regulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "regulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "regulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "regulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "regulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "regulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie]
synonym: "regulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie]
is_a: GO:0072215 ! regulation of metanephros development
is_a: GO:1904748 ! regulation of apoptotic process involved in development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900204 ! apoptotic process involved in metanephric collecting duct development
relationship: regulates GO:1900204 ! apoptotic process involved in metanephric collecting duct development
created_by: yaf
creation_date: 2012-03-22T10:53:21Z

[Term]
id: GO:1900215
name: negative regulation of apoptotic process involved in metanephric collecting duct development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in metanephric collecting duct development." [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325]
synonym: "down regulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "down regulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "down regulation of apoptotic process involved in metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "down regulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "down regulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "down regulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "down regulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "down regulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie]
synonym: "down regulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptotic process involved in metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "down-regulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "down-regulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie]
synonym: "down-regulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptotic process involved in metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "downregulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "downregulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie]
synonym: "downregulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "inhibition of apoptotic process involved in metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "inhibition of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "inhibition of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "inhibition of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie]
synonym: "inhibition of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "negative regulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "negative regulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "negative regulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "negative regulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie]
synonym: "negative regulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie]
is_a: GO:0072217 ! negative regulation of metanephros development
is_a: GO:1900214 ! regulation of apoptotic process involved in metanephric collecting duct development
is_a: GO:1904746 ! negative regulation of apoptotic process involved in development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900204 ! apoptotic process involved in metanephric collecting duct development
relationship: negatively_regulates GO:1900204 ! apoptotic process involved in metanephric collecting duct development
created_by: yaf
creation_date: 2012-03-22T10:53:31Z

[Term]
id: GO:1900216
name: positive regulation of apoptotic process involved in metanephric collecting duct development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in metanephric collecting duct development." [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325]
synonym: "activation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "activation of apoptotic process involved in metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "activation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "activation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "activation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie]
synonym: "activation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "positive regulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "positive regulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "positive regulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "positive regulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie]
synonym: "positive regulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptotic process involved in metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "up regulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "up regulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie]
synonym: "up regulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptotic process involved in metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "up-regulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "up-regulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie]
synonym: "up-regulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptotic process involved in metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "upregulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "upregulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie]
synonym: "upregulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie]
is_a: GO:0072216 ! positive regulation of metanephros development
is_a: GO:1900214 ! regulation of apoptotic process involved in metanephric collecting duct development
is_a: GO:1904747 ! positive regulation of apoptotic process involved in development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900204 ! apoptotic process involved in metanephric collecting duct development
relationship: positively_regulates GO:1900204 ! apoptotic process involved in metanephric collecting duct development
created_by: yaf
creation_date: 2012-03-22T10:53:39Z

[Term]
id: GO:1900217
name: regulation of apoptotic process involved in metanephric nephron tubule development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of apoptotic process involved in metanephric nephron tubule development." [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325]
synonym: "regulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "regulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "regulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "regulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "regulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "regulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "regulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie]
synonym: "regulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie]
is_a: GO:0072215 ! regulation of metanephros development
is_a: GO:1904748 ! regulation of apoptotic process involved in development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900205 ! apoptotic process involved in metanephric nephron tubule development
relationship: regulates GO:1900205 ! apoptotic process involved in metanephric nephron tubule development
created_by: yaf
creation_date: 2012-03-22T10:53:51Z

[Term]
id: GO:1900218
name: negative regulation of apoptotic process involved in metanephric nephron tubule development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in metanephric nephron tubule development." [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325]
synonym: "down regulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "down regulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "down regulation of apoptotic process involved in metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "down regulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "down regulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "down regulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "down regulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "down regulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie]
synonym: "down regulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptotic process involved in metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "down-regulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "down-regulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie]
synonym: "down-regulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptotic process involved in metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "downregulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "downregulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie]
synonym: "downregulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "inhibition of apoptotic process involved in metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "inhibition of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "inhibition of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "inhibition of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie]
synonym: "inhibition of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "negative regulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "negative regulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "negative regulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "negative regulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie]
synonym: "negative regulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie]
is_a: GO:0072217 ! negative regulation of metanephros development
is_a: GO:1900217 ! regulation of apoptotic process involved in metanephric nephron tubule development
is_a: GO:1904746 ! negative regulation of apoptotic process involved in development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900205 ! apoptotic process involved in metanephric nephron tubule development
relationship: negatively_regulates GO:1900205 ! apoptotic process involved in metanephric nephron tubule development
created_by: yaf
creation_date: 2012-03-22T10:54:01Z

[Term]
id: GO:1900219
name: positive regulation of apoptotic process involved in metanephric nephron tubule development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in metanephric nephron tubule development." [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325]
synonym: "activation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "activation of apoptotic process involved in metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "activation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "activation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "activation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie]
synonym: "activation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "positive regulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "positive regulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "positive regulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "positive regulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie]
synonym: "positive regulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptotic process involved in metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "up regulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "up regulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie]
synonym: "up regulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptotic process involved in metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "up-regulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "up-regulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie]
synonym: "up-regulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptotic process involved in metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "upregulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "upregulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie]
synonym: "upregulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie]
is_a: GO:0072216 ! positive regulation of metanephros development
is_a: GO:1900217 ! regulation of apoptotic process involved in metanephric nephron tubule development
is_a: GO:1904747 ! positive regulation of apoptotic process involved in development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900205 ! apoptotic process involved in metanephric nephron tubule development
relationship: positively_regulates GO:1900205 ! apoptotic process involved in metanephric nephron tubule development
created_by: yaf
creation_date: 2012-03-22T10:54:09Z

[Term]
id: GO:1900220
name: semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis
namespace: biological_process
def: "Any semaphorin-plexin signaling pathway that contributes to bone trabecula morphogenesis." [GOC:BHF, GOC:TermGenie]
synonym: "semaphorin-plexin signaling pathway of bone trabecula morphogenesis" EXACT [GOC:TermGenie]
synonym: "semaphorin-plexin signalling pathway of bone trabecula morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:0071526 ! semaphorin-plexin signaling pathway
intersection_of: GO:0071526 ! semaphorin-plexin signaling pathway
intersection_of: part_of GO:0061430 ! bone trabecula morphogenesis
relationship: part_of GO:0061430 ! bone trabecula morphogenesis
created_by: vk
creation_date: 2012-03-22T01:13:56Z

[Term]
id: GO:1900221
name: regulation of beta-amyloid clearance
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of beta-amyloid clearance." [GOC:BHF, GOC:TermGenie]
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097242 ! beta-amyloid clearance
relationship: regulates GO:0097242 ! beta-amyloid clearance
created_by: vk
creation_date: 2012-03-22T01:29:32Z

[Term]
id: GO:1900222
name: negative regulation of beta-amyloid clearance
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of beta-amyloid clearance." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of beta-amyloid clearance" EXACT [GOC:TermGenie]
synonym: "down-regulation of beta-amyloid clearance" EXACT [GOC:TermGenie]
synonym: "downregulation of beta-amyloid clearance" EXACT [GOC:TermGenie]
synonym: "inhibition of beta-amyloid clearance" NARROW [GOC:TermGenie]
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1900221 ! regulation of beta-amyloid clearance
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097242 ! beta-amyloid clearance
relationship: negatively_regulates GO:0097242 ! beta-amyloid clearance
created_by: vk
creation_date: 2012-03-22T01:29:41Z

[Term]
id: GO:1900223
name: positive regulation of beta-amyloid clearance
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of beta-amyloid clearance." [GOC:BHF, GOC:TermGenie]
synonym: "activation of beta-amyloid clearance" NARROW [GOC:TermGenie]
synonym: "up regulation of beta-amyloid clearance" EXACT [GOC:TermGenie]
synonym: "up-regulation of beta-amyloid clearance" EXACT [GOC:TermGenie]
synonym: "upregulation of beta-amyloid clearance" EXACT [GOC:TermGenie]
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1900221 ! regulation of beta-amyloid clearance
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097242 ! beta-amyloid clearance
relationship: positively_regulates GO:0097242 ! beta-amyloid clearance
created_by: vk
creation_date: 2012-03-22T01:29:50Z

[Term]
id: GO:1900224
name: positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry." [GOC:BHF, GOC:TermGenie]
synonym: "activation of nodal signaling of determination of left/right asymmetry in lateral mesoderm" EXACT [GOC:TermGenie]
synonym: "activation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry" NARROW [GOC:TermGenie]
synonym: "activation of nodal signaling pathway of determination of left/right asymmetry in lateral mesoderm" EXACT [GOC:TermGenie]
synonym: "positive regulation of nodal signaling of determination of left/right asymmetry in lateral mesoderm" EXACT [GOC:TermGenie]
synonym: "positive regulation of nodal signaling pathway of determination of left/right asymmetry in lateral mesoderm" EXACT [GOC:TermGenie]
synonym: "positive regulation of nodal signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:mah]
synonym: "up regulation of nodal signaling of determination of left/right asymmetry in lateral mesoderm" EXACT [GOC:TermGenie]
synonym: "up regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie]
synonym: "up regulation of nodal signaling pathway of determination of left/right asymmetry in lateral mesoderm" EXACT [GOC:TermGenie]
synonym: "up-regulation of nodal signaling of determination of left/right asymmetry in lateral mesoderm" EXACT [GOC:TermGenie]
synonym: "up-regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie]
synonym: "up-regulation of nodal signaling pathway of determination of left/right asymmetry in lateral mesoderm" EXACT [GOC:TermGenie]
synonym: "upregulation of nodal signaling of determination of left/right asymmetry in lateral mesoderm" EXACT [GOC:TermGenie]
synonym: "upregulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie]
synonym: "upregulation of nodal signaling pathway of determination of left/right asymmetry in lateral mesoderm" EXACT [GOC:TermGenie]
is_a: GO:0032927 ! positive regulation of activin receptor signaling pathway
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1900175 ! regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
is_a: GO:2000382 ! positive regulation of mesoderm development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900164 ! nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
relationship: positively_regulates GO:1900164 ! nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
created_by: vk
creation_date: 2012-03-22T02:30:13Z

[Term]
id: GO:1900225
name: regulation of NLRP3 inflammasome complex assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of NLRP3 inflammasome complex assembly." [GOC:TermGenie]
synonym: "regulation of NALP3 inflammasome complex assembly" EXACT [GOC:TermGenie]
synonym: "regulation of NLRP3 inflammasome activation" RELATED [GOC:TermGenie]
is_a: GO:0043254 ! regulation of protein complex assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044546 ! NLRP3 inflammasome complex assembly
relationship: regulates GO:0044546 ! NLRP3 inflammasome complex assembly
created_by: jl
creation_date: 2012-03-22T04:18:14Z

[Term]
id: GO:1900226
name: negative regulation of NLRP3 inflammasome complex assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of NLRP3 inflammasome complex assembly." [GOC:TermGenie]
synonym: "down regulation of NALP3 inflammasome complex assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of NLRP3 inflammasome activation" RELATED [GOC:TermGenie]
synonym: "down regulation of NLRP3 inflammasome complex assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of NALP3 inflammasome complex assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of NLRP3 inflammasome activation" RELATED [GOC:TermGenie]
synonym: "down-regulation of NLRP3 inflammasome complex assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of NALP3 inflammasome complex assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of NLRP3 inflammasome activation" RELATED [GOC:TermGenie]
synonym: "downregulation of NLRP3 inflammasome complex assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of NALP3 inflammasome complex assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of NLRP3 inflammasome activation" RELATED [GOC:TermGenie]
synonym: "inhibition of NLRP3 inflammasome complex assembly" NARROW [GOC:TermGenie]
synonym: "negative regulation of NALP3 inflammasome complex assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of NLRP3 inflammasome activation" RELATED [GOC:TermGenie]
is_a: GO:0031333 ! negative regulation of protein complex assembly
is_a: GO:1900225 ! regulation of NLRP3 inflammasome complex assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044546 ! NLRP3 inflammasome complex assembly
relationship: negatively_regulates GO:0044546 ! NLRP3 inflammasome complex assembly
created_by: jl
creation_date: 2012-03-22T04:18:24Z

[Term]
id: GO:1900227
name: positive regulation of NLRP3 inflammasome complex assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of NLRP3 inflammasome complex assembly." [GOC:TermGenie]
synonym: "activation of NALP3 inflammasome complex assembly" EXACT [GOC:TermGenie]
synonym: "activation of NLRP3 inflammasome activation" RELATED [GOC:TermGenie]
synonym: "activation of NLRP3 inflammasome complex assembly" NARROW [GOC:TermGenie]
synonym: "positive regulation of NALP3 inflammasome complex assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of NLRP3 inflammasome activation" RELATED [GOC:TermGenie]
synonym: "up regulation of NALP3 inflammasome complex assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of NLRP3 inflammasome activation" RELATED [GOC:TermGenie]
synonym: "up regulation of NLRP3 inflammasome complex assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of NALP3 inflammasome complex assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of NLRP3 inflammasome activation" RELATED [GOC:TermGenie]
synonym: "up-regulation of NLRP3 inflammasome complex assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of NALP3 inflammasome complex assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of NLRP3 inflammasome activation" RELATED [GOC:TermGenie]
synonym: "upregulation of NLRP3 inflammasome complex assembly" EXACT [GOC:TermGenie]
is_a: GO:0031334 ! positive regulation of protein complex assembly
is_a: GO:1900225 ! regulation of NLRP3 inflammasome complex assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044546 ! NLRP3 inflammasome complex assembly
relationship: positively_regulates GO:0044546 ! NLRP3 inflammasome complex assembly
created_by: jl
creation_date: 2012-03-22T04:18:32Z

[Term]
id: GO:1900228
name: regulation of single-species biofilm formation in or on host organism
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of single-species biofilm formation in or on host organism." [GOC:di, GOC:TermGenie]
is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism
is_a: GO:1900190 ! regulation of single-species biofilm formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044407 ! single-species biofilm formation in or on host organism
relationship: regulates GO:0044407 ! single-species biofilm formation in or on host organism
created_by: di
creation_date: 2012-03-23T04:36:54Z

[Term]
id: GO:1900229
name: negative regulation of single-species biofilm formation in or on host organism
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of single-species biofilm formation in or on host organism." [GOC:di, GOC:TermGenie]
synonym: "down regulation of single-species biofilm formation in or on host organism" EXACT [GOC:TermGenie]
synonym: "down-regulation of single-species biofilm formation in or on host organism" EXACT [GOC:TermGenie]
synonym: "downregulation of single-species biofilm formation in or on host organism" EXACT [GOC:TermGenie]
synonym: "inhibition of single-species biofilm formation in or on host organism" NARROW [GOC:TermGenie]
is_a: GO:1900191 ! negative regulation of single-species biofilm formation
is_a: GO:1900228 ! regulation of single-species biofilm formation in or on host organism
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044407 ! single-species biofilm formation in or on host organism
relationship: negatively_regulates GO:0044407 ! single-species biofilm formation in or on host organism
created_by: di
creation_date: 2012-03-23T04:37:05Z

[Term]
id: GO:1900230
name: positive regulation of single-species biofilm formation in or on host organism
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of single-species biofilm formation in or on host organism." [GOC:di, GOC:TermGenie]
synonym: "activation of single-species biofilm formation in or on host organism" NARROW [GOC:TermGenie]
synonym: "up regulation of single-species biofilm formation in or on host organism" EXACT [GOC:TermGenie]
synonym: "up-regulation of single-species biofilm formation in or on host organism" EXACT [GOC:TermGenie]
synonym: "upregulation of single-species biofilm formation in or on host organism" EXACT [GOC:TermGenie]
is_a: GO:1900192 ! positive regulation of single-species biofilm formation
is_a: GO:1900228 ! regulation of single-species biofilm formation in or on host organism
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044407 ! single-species biofilm formation in or on host organism
relationship: positively_regulates GO:0044407 ! single-species biofilm formation in or on host organism
created_by: di
creation_date: 2012-03-23T04:37:14Z

[Term]
id: GO:1900231
name: regulation of single-species biofilm formation on inanimate substrate
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of single-species biofilm formation on inanimate substrate." [GOC:di, GOC:TermGenie]
is_a: GO:1900190 ! regulation of single-species biofilm formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044011 ! single-species biofilm formation on inanimate substrate
relationship: regulates GO:0044011 ! single-species biofilm formation on inanimate substrate
created_by: di
creation_date: 2012-03-23T04:40:35Z

[Term]
id: GO:1900232
name: negative regulation of single-species biofilm formation on inanimate substrate
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of single-species biofilm formation on inanimate substrate." [GOC:di, GOC:TermGenie]
synonym: "down regulation of single-species biofilm formation on inanimate substrate" EXACT [GOC:TermGenie]
synonym: "down-regulation of single-species biofilm formation on inanimate substrate" EXACT [GOC:TermGenie]
synonym: "downregulation of single-species biofilm formation on inanimate substrate" EXACT [GOC:TermGenie]
synonym: "inhibition of single-species biofilm formation on inanimate substrate" NARROW [GOC:TermGenie]
is_a: GO:1900191 ! negative regulation of single-species biofilm formation
is_a: GO:1900231 ! regulation of single-species biofilm formation on inanimate substrate
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044011 ! single-species biofilm formation on inanimate substrate
relationship: negatively_regulates GO:0044011 ! single-species biofilm formation on inanimate substrate
created_by: di
creation_date: 2012-03-23T04:40:45Z

[Term]
id: GO:1900233
name: positive regulation of single-species biofilm formation on inanimate substrate
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of single-species biofilm formation on inanimate substrate." [GOC:di, GOC:TermGenie]
synonym: "activation of single-species biofilm formation on inanimate substrate" NARROW [GOC:TermGenie]
synonym: "up regulation of single-species biofilm formation on inanimate substrate" EXACT [GOC:TermGenie]
synonym: "up-regulation of single-species biofilm formation on inanimate substrate" EXACT [GOC:TermGenie]
synonym: "upregulation of single-species biofilm formation on inanimate substrate" EXACT [GOC:TermGenie]
is_a: GO:1900192 ! positive regulation of single-species biofilm formation
is_a: GO:1900231 ! regulation of single-species biofilm formation on inanimate substrate
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044011 ! single-species biofilm formation on inanimate substrate
relationship: positively_regulates GO:0044011 ! single-species biofilm formation on inanimate substrate
created_by: di
creation_date: 2012-03-23T04:40:53Z

[Term]
id: GO:1900234
name: regulation of Kit signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Kit signaling pathway." [GOC:signaling, GOC:TermGenie]
synonym: "regulation of Kit signalling pathway" EXACT [GOC:mah]
synonym: "regulation of stem cell factor receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "regulation of stem cell factor signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0038109 ! Kit signaling pathway
relationship: regulates GO:0038109 ! Kit signaling pathway
created_by: bf
creation_date: 2012-03-23T02:54:13Z

[Term]
id: GO:1900235
name: negative regulation of Kit signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of Kit signaling pathway." [GOC:signaling, GOC:TermGenie]
synonym: "down regulation of Kit signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of stem cell factor receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of stem cell factor signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of Kit signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of stem cell factor receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of stem cell factor signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of Kit signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of stem cell factor receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of stem cell factor signaling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of Kit signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of stem cell factor receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of stem cell factor signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of Kit signalling pathway" EXACT [GOC:mah]
synonym: "negative regulation of stem cell factor receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of stem cell factor signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway
is_a: GO:1900234 ! regulation of Kit signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0038109 ! Kit signaling pathway
relationship: negatively_regulates GO:0038109 ! Kit signaling pathway
created_by: bf
creation_date: 2012-03-23T02:54:23Z

[Term]
id: GO:1900236
name: positive regulation of Kit signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of Kit signaling pathway." [GOC:signaling, GOC:TermGenie]
synonym: "activation of Kit signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of stem cell factor receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "activation of stem cell factor signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of Kit signalling pathway" EXACT [GOC:mah]
synonym: "positive regulation of stem cell factor receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of stem cell factor signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of Kit signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of stem cell factor receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of stem cell factor signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of Kit signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of stem cell factor receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of stem cell factor signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of Kit signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of stem cell factor receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of stem cell factor signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway
is_a: GO:1900234 ! regulation of Kit signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0038109 ! Kit signaling pathway
relationship: positively_regulates GO:0038109 ! Kit signaling pathway
created_by: bf
creation_date: 2012-03-23T02:54:32Z

[Term]
id: GO:1900237
name: positive regulation of induction of conjugation with cellular fusion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of induction of conjugation with cellular fusion." [GOC:TermGenie]
synonym: "up regulation of induction of conjugation with cellular fusion" EXACT [GOC:TermGenie]
synonym: "up-regulation of induction of conjugation with cellular fusion" EXACT [GOC:TermGenie]
synonym: "upregulation of induction of conjugation with cellular fusion" EXACT [GOC:TermGenie]
is_a: GO:0031137 ! regulation of conjugation with cellular fusion
is_a: GO:0048518 ! positive regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010514 ! induction of conjugation with cellular fusion
relationship: positively_regulates GO:0010514 ! induction of conjugation with cellular fusion
created_by: al
creation_date: 2012-03-26T10:14:16Z

[Term]
id: GO:1900238
name: regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of regulation of metanephric mesenchymal cell migration, by platelet-derived growth factor receptor-beta signaling pathway." [GOC:mtg_kidney_jan10, GOC:TermGenie, goc:yaf, PMID:19450854]
synonym: "regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signalling pathway" EXACT [GOC:mah]
synonym: "regulation of metanephric mesenchyme chemotaxis by platelet-derived growth factor receptor-beta signaling pathway" RELATED [GOC:TermGenie]
is_a: GO:0035791 ! platelet-derived growth factor receptor-beta signaling pathway
is_a: GO:2000589 ! regulation of metanephric mesenchymal cell migration
intersection_of: GO:0035791 ! platelet-derived growth factor receptor-beta signaling pathway
intersection_of: regulates GO:0035789 ! metanephric mesenchymal cell migration
relationship: regulates GO:0035789 ! metanephric mesenchymal cell migration
created_by: yaf
creation_date: 2012-03-27T03:33:56Z

[Term]
id: GO:1900239
name: regulation of phenotypic switching
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phenotypic switching." [GOC:di, GOC:TermGenie]
synonym: "regulation of phenotypic dimorphism" RELATED [GOC:TermGenie]
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0036166 ! phenotypic switching
relationship: regulates GO:0036166 ! phenotypic switching
created_by: di
creation_date: 2012-03-28T01:49:16Z

[Term]
id: GO:1900240
name: negative regulation of phenotypic switching
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of phenotypic switching." [GOC:di, GOC:TermGenie]
synonym: "down regulation of phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "down regulation of phenotypic switching" EXACT [GOC:TermGenie]
synonym: "down-regulation of phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "down-regulation of phenotypic switching" EXACT [GOC:TermGenie]
synonym: "downregulation of phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "downregulation of phenotypic switching" EXACT [GOC:TermGenie]
synonym: "inhibition of phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "inhibition of phenotypic switching" NARROW [GOC:TermGenie]
synonym: "negative regulation of phenotypic dimorphism" RELATED [GOC:TermGenie]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:1900239 ! regulation of phenotypic switching
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0036166 ! phenotypic switching
relationship: negatively_regulates GO:0036166 ! phenotypic switching
created_by: di
creation_date: 2012-03-28T01:49:26Z

[Term]
id: GO:1900241
name: positive regulation of phenotypic switching
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phenotypic switching." [GOC:di, GOC:TermGenie]
synonym: "activation of phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "activation of phenotypic switching" NARROW [GOC:TermGenie]
synonym: "positive regulation of phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "up regulation of phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "up regulation of phenotypic switching" EXACT [GOC:TermGenie]
synonym: "up-regulation of phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "up-regulation of phenotypic switching" EXACT [GOC:TermGenie]
synonym: "upregulation of phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "upregulation of phenotypic switching" EXACT [GOC:TermGenie]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:1900239 ! regulation of phenotypic switching
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0036166 ! phenotypic switching
relationship: positively_regulates GO:0036166 ! phenotypic switching
created_by: di
creation_date: 2012-03-28T01:49:34Z

[Term]
id: GO:1900242
name: regulation of synaptic vesicle endocytosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synaptic vesicle endocytosis." [GOC:BHF, GOC:TermGenie]
synonym: "regulation of synaptic vesicle retrieval" RELATED [GOC:TermGenie]
is_a: GO:1903421 ! regulation of synaptic vesicle recycling
is_a: GO:2000369 ! regulation of clathrin-mediated endocytosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048488 ! synaptic vesicle endocytosis
relationship: regulates GO:0048488 ! synaptic vesicle endocytosis
created_by: rl
creation_date: 2012-03-28T01:40:26Z

[Term]
id: GO:1900243
name: negative regulation of synaptic vesicle endocytosis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle endocytosis." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of synaptic vesicle endocytosis" EXACT [GOC:TermGenie]
synonym: "down regulation of synaptic vesicle retrieval" RELATED [GOC:TermGenie]
synonym: "down-regulation of synaptic vesicle endocytosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of synaptic vesicle retrieval" RELATED [GOC:TermGenie]
synonym: "downregulation of synaptic vesicle endocytosis" EXACT [GOC:TermGenie]
synonym: "downregulation of synaptic vesicle retrieval" RELATED [GOC:TermGenie]
synonym: "inhibition of synaptic vesicle endocytosis" NARROW [GOC:TermGenie]
synonym: "inhibition of synaptic vesicle retrieval" RELATED [GOC:TermGenie]
synonym: "negative regulation of synaptic vesicle retrieval" RELATED [GOC:TermGenie]
is_a: GO:1900186 ! negative regulation of clathrin-mediated endocytosis
is_a: GO:1900242 ! regulation of synaptic vesicle endocytosis
is_a: GO:1903422 ! negative regulation of synaptic vesicle recycling
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048488 ! synaptic vesicle endocytosis
relationship: negatively_regulates GO:0048488 ! synaptic vesicle endocytosis
created_by: rl
creation_date: 2012-03-28T01:40:36Z

[Term]
id: GO:1900244
name: positive regulation of synaptic vesicle endocytosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of synaptic vesicle endocytosis." [GOC:BHF, GOC:TermGenie]
synonym: "activation of synaptic vesicle endocytosis" NARROW [GOC:TermGenie]
synonym: "activation of synaptic vesicle retrieval" RELATED [GOC:TermGenie]
synonym: "positive regulation of synaptic vesicle retrieval" RELATED [GOC:TermGenie]
synonym: "up regulation of synaptic vesicle endocytosis" EXACT [GOC:TermGenie]
synonym: "up regulation of synaptic vesicle retrieval" RELATED [GOC:TermGenie]
synonym: "up-regulation of synaptic vesicle endocytosis" EXACT [GOC:TermGenie]
synonym: "up-regulation of synaptic vesicle retrieval" RELATED [GOC:TermGenie]
synonym: "upregulation of synaptic vesicle endocytosis" EXACT [GOC:TermGenie]
synonym: "upregulation of synaptic vesicle retrieval" RELATED [GOC:TermGenie]
is_a: GO:1900242 ! regulation of synaptic vesicle endocytosis
is_a: GO:1903423 ! positive regulation of synaptic vesicle recycling
is_a: GO:2000370 ! positive regulation of clathrin-mediated endocytosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048488 ! synaptic vesicle endocytosis
relationship: positively_regulates GO:0048488 ! synaptic vesicle endocytosis
created_by: rl
creation_date: 2012-03-28T01:40:44Z

[Term]
id: GO:1900245
name: positive regulation of MDA-5 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of MDA-5 signaling pathway." [GOC:TermGenie]
synonym: "activation of IFIH1 signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of MDA-5 signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of MDA5 signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of melanoma differentiation-associated gene 5 signaling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of IFIH1 signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of MDA-5 signalling pathway" EXACT [GOC:mah]
synonym: "positive regulation of MDA5 signaling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of melanoma differentiation-associated gene 5 signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of IFIH1 signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of MDA-5 signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of MDA5 signaling pathway" NARROW [GOC:TermGenie]
synonym: "up regulation of melanoma differentiation-associated gene 5 signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of IFIH1 signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of MDA-5 signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of MDA5 signaling pathway" NARROW [GOC:TermGenie]
synonym: "up-regulation of melanoma differentiation-associated gene 5 signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of IFIH1 signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of MDA-5 signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of MDA5 signaling pathway" NARROW [GOC:TermGenie]
synonym: "upregulation of melanoma differentiation-associated gene 5 signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0002833 ! positive regulation of response to biotic stimulus
is_a: GO:0031349 ! positive regulation of defense response
is_a: GO:0032103 ! positive regulation of response to external stimulus
is_a: GO:0039533 ! regulation of MDA-5 signaling pathway
is_a: GO:0043902 ! positive regulation of multi-organism process
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0039530 ! MDA-5 signaling pathway
relationship: positively_regulates GO:0039530 ! MDA-5 signaling pathway
created_by: ss
creation_date: 2012-04-02T10:55:38Z

[Term]
id: GO:1900246
name: positive regulation of RIG-I signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of RIG-I signaling pathway." [GOC:TermGenie]
synonym: "activation of DDX58 signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of retinoic acid inducible gene I signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of RIG-I signaling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of DDX58 signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of retinoic acid inducible gene I signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of RIG-I signalling pathway" EXACT [GOC:mah]
synonym: "up regulation of DDX58 signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of retinoic acid inducible gene I signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of RIG-I signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of DDX58 signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of retinoic acid inducible gene I signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of RIG-I signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of DDX58 signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of retinoic acid inducible gene I signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of RIG-I signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0002833 ! positive regulation of response to biotic stimulus
is_a: GO:0031349 ! positive regulation of defense response
is_a: GO:0032103 ! positive regulation of response to external stimulus
is_a: GO:0039535 ! regulation of RIG-I signaling pathway
is_a: GO:0043902 ! positive regulation of multi-organism process
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0039529 ! RIG-I signaling pathway
relationship: positively_regulates GO:0039529 ! RIG-I signaling pathway
created_by: ss
creation_date: 2012-04-02T11:00:28Z

[Term]
id: GO:1900247
name: regulation of cytoplasmic translational elongation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cytoplasmic translational elongation." [GOC:TermGenie]
is_a: GO:0006448 ! regulation of translational elongation
is_a: GO:2000765 ! regulation of cytoplasmic translation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002182 ! cytoplasmic translational elongation
relationship: regulates GO:0002182 ! cytoplasmic translational elongation
created_by: vw
creation_date: 2012-04-03T05:07:02Z

[Term]
id: GO:1900248
name: negative regulation of cytoplasmic translational elongation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translational elongation." [GOC:TermGenie]
synonym: "down regulation of cytoplasmic translational elongation" EXACT [GOC:TermGenie]
synonym: "down-regulation of cytoplasmic translational elongation" EXACT [GOC:TermGenie]
synonym: "downregulation of cytoplasmic translational elongation" EXACT [GOC:TermGenie]
synonym: "inhibition of cytoplasmic translational elongation" NARROW [GOC:TermGenie]
is_a: GO:0045900 ! negative regulation of translational elongation
is_a: GO:1900247 ! regulation of cytoplasmic translational elongation
is_a: GO:2000766 ! negative regulation of cytoplasmic translation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002182 ! cytoplasmic translational elongation
relationship: negatively_regulates GO:0002182 ! cytoplasmic translational elongation
created_by: vw
creation_date: 2012-04-03T05:07:14Z

[Term]
id: GO:1900249
name: positive regulation of cytoplasmic translational elongation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cytoplasmic translational elongation." [GOC:TermGenie]
synonym: "activation of cytoplasmic translational elongation" NARROW [GOC:TermGenie]
synonym: "up regulation of cytoplasmic translational elongation" EXACT [GOC:TermGenie]
synonym: "up-regulation of cytoplasmic translational elongation" EXACT [GOC:TermGenie]
synonym: "upregulation of cytoplasmic translational elongation" EXACT [GOC:TermGenie]
is_a: GO:0045901 ! positive regulation of translational elongation
is_a: GO:1900247 ! regulation of cytoplasmic translational elongation
is_a: GO:2000767 ! positive regulation of cytoplasmic translation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002182 ! cytoplasmic translational elongation
relationship: positively_regulates GO:0002182 ! cytoplasmic translational elongation
created_by: vw
creation_date: 2012-04-03T05:07:24Z

[Term]
id: GO:1900256
name: regulation of beta1-adrenergic receptor activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of beta1-adrenergic receptor activity." [GOC:TermGenie]
synonym: "regulation of beta1 adrenoceptor" EXACT [GOC:TermGenie]
is_a: GO:0010469 ! regulation of receptor activity
is_a: GO:0071877 ! regulation of adrenergic receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004940 ! beta1-adrenergic receptor activity
relationship: regulates GO:0004940 ! beta1-adrenergic receptor activity
created_by: tb
creation_date: 2012-04-03T10:59:21Z

[Term]
id: GO:1900257
name: negative regulation of beta1-adrenergic receptor activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of beta1-adrenergic receptor activity." [GOC:TermGenie]
synonym: "down regulation of beta1 adrenoceptor" EXACT [GOC:TermGenie]
synonym: "down regulation of beta1-adrenergic receptor activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of beta1 adrenoceptor" EXACT [GOC:TermGenie]
synonym: "down-regulation of beta1-adrenergic receptor activity" EXACT [GOC:TermGenie]
synonym: "downregulation of beta1 adrenoceptor" EXACT [GOC:TermGenie]
synonym: "downregulation of beta1-adrenergic receptor activity" EXACT [GOC:TermGenie]
synonym: "inhibition of beta1 adrenoceptor" EXACT [GOC:TermGenie]
synonym: "inhibition of beta1-adrenergic receptor activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of beta1 adrenoceptor" EXACT [GOC:TermGenie]
is_a: GO:0071878 ! negative regulation of adrenergic receptor signaling pathway
is_a: GO:1900256 ! regulation of beta1-adrenergic receptor activity
is_a: GO:2000272 ! negative regulation of receptor activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004940 ! beta1-adrenergic receptor activity
relationship: negatively_regulates GO:0004940 ! beta1-adrenergic receptor activity
created_by: tb
creation_date: 2012-04-03T10:59:40Z

[Term]
id: GO:1900258
name: positive regulation of beta1-adrenergic receptor activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of beta1-adrenergic receptor activity." [GOC:TermGenie]
synonym: "activation of beta1 adrenoceptor" EXACT [GOC:TermGenie]
synonym: "activation of beta1-adrenergic receptor activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of beta1 adrenoceptor" EXACT [GOC:TermGenie]
synonym: "up regulation of beta1 adrenoceptor" EXACT [GOC:TermGenie]
synonym: "up regulation of beta1-adrenergic receptor activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of beta1 adrenoceptor" EXACT [GOC:TermGenie]
synonym: "up-regulation of beta1-adrenergic receptor activity" EXACT [GOC:TermGenie]
synonym: "upregulation of beta1 adrenoceptor" EXACT [GOC:TermGenie]
synonym: "upregulation of beta1-adrenergic receptor activity" EXACT [GOC:TermGenie]
is_a: GO:0071879 ! positive regulation of adrenergic receptor signaling pathway
is_a: GO:1900256 ! regulation of beta1-adrenergic receptor activity
is_a: GO:2000273 ! positive regulation of receptor activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004940 ! beta1-adrenergic receptor activity
relationship: positively_regulates GO:0004940 ! beta1-adrenergic receptor activity
created_by: tb
creation_date: 2012-04-03T10:59:49Z

[Term]
id: GO:1900259
name: regulation of RNA-directed RNA polymerase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of RNA-directed RNA polymerase activity." [GOC:TermGenie]
synonym: "regulation of 3D polymerase activity" EXACT [GOC:TermGenie]
synonym: "regulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)" EXACT [GOC:TermGenie]
synonym: "regulation of PB1 proteins" RELATED [GOC:TermGenie]
synonym: "regulation of PB2 proteins" RELATED [GOC:TermGenie]
synonym: "regulation of phage f2 replicase" NARROW [GOC:TermGenie]
synonym: "regulation of polymerase L" RELATED [GOC:TermGenie]
synonym: "regulation of Q-beta replicase activity" EXACT [GOC:TermGenie]
synonym: "regulation of RDRP" RELATED [GOC:TermGenie]
synonym: "regulation of ribonucleic acid replicase activity" EXACT [GOC:TermGenie]
synonym: "regulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of ribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [GOC:TermGenie]
synonym: "regulation of ribonucleic replicase activity" EXACT [GOC:TermGenie]
synonym: "regulation of ribonucleic synthetase activity" RELATED [GOC:TermGenie]
synonym: "regulation of RNA nucleotidyltransferase (RNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "regulation of RNA replicase activity" EXACT [GOC:TermGenie]
synonym: "regulation of RNA synthetase activity" RELATED [GOC:TermGenie]
synonym: "regulation of RNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of RNA-dependent RNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "regulation of RNA-dependent RNA replicase activity" EXACT [GOC:TermGenie]
synonym: "regulation of transcriptase" BROAD [GOC:TermGenie]
is_a: GO:0051338 ! regulation of transferase activity
is_a: GO:1903506 ! regulation of nucleic acid-templated transcription
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003968 ! RNA-directed RNA polymerase activity
relationship: regulates GO:0003968 ! RNA-directed RNA polymerase activity
created_by: tb
creation_date: 2012-04-03T11:01:53Z

[Term]
id: GO:1900260
name: negative regulation of RNA-directed RNA polymerase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA-directed RNA polymerase activity." [GOC:TermGenie]
synonym: "down regulation of 3D polymerase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)" EXACT [GOC:TermGenie]
synonym: "down regulation of PB1 proteins" RELATED [GOC:TermGenie]
synonym: "down regulation of PB2 proteins" RELATED [GOC:TermGenie]
synonym: "down regulation of phage f2 replicase" NARROW [GOC:TermGenie]
synonym: "down regulation of polymerase L" RELATED [GOC:TermGenie]
synonym: "down regulation of Q-beta replicase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of RDRP" RELATED [GOC:TermGenie]
synonym: "down regulation of ribonucleic acid replicase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of ribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of ribonucleic replicase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of ribonucleic synthetase activity" RELATED [GOC:TermGenie]
synonym: "down regulation of RNA nucleotidyltransferase (RNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "down regulation of RNA replicase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of RNA synthetase activity" RELATED [GOC:TermGenie]
synonym: "down regulation of RNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of RNA-dependent RNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of RNA-dependent RNA replicase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of RNA-directed RNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of transcriptase" BROAD [GOC:TermGenie]
synonym: "down-regulation of 3D polymerase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)" EXACT [GOC:TermGenie]
synonym: "down-regulation of PB1 proteins" RELATED [GOC:TermGenie]
synonym: "down-regulation of PB2 proteins" RELATED [GOC:TermGenie]
synonym: "down-regulation of phage f2 replicase" NARROW [GOC:TermGenie]
synonym: "down-regulation of polymerase L" RELATED [GOC:TermGenie]
synonym: "down-regulation of Q-beta replicase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of RDRP" RELATED [GOC:TermGenie]
synonym: "down-regulation of ribonucleic acid replicase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of ribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of ribonucleic replicase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of ribonucleic synthetase activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of RNA nucleotidyltransferase (RNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA replicase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA synthetase activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of RNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA-dependent RNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA-dependent RNA replicase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA-directed RNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of transcriptase" BROAD [GOC:TermGenie]
synonym: "downregulation of 3D polymerase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)" EXACT [GOC:TermGenie]
synonym: "downregulation of PB1 proteins" RELATED [GOC:TermGenie]
synonym: "downregulation of PB2 proteins" RELATED [GOC:TermGenie]
synonym: "downregulation of phage f2 replicase" NARROW [GOC:TermGenie]
synonym: "downregulation of polymerase L" RELATED [GOC:TermGenie]
synonym: "downregulation of Q-beta replicase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of RDRP" RELATED [GOC:TermGenie]
synonym: "downregulation of ribonucleic acid replicase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of ribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of ribonucleic replicase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of ribonucleic synthetase activity" RELATED [GOC:TermGenie]
synonym: "downregulation of RNA nucleotidyltransferase (RNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA replicase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA synthetase activity" RELATED [GOC:TermGenie]
synonym: "downregulation of RNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA-dependent RNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA-dependent RNA replicase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA-directed RNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of transcriptase" BROAD [GOC:TermGenie]
synonym: "inhibition of 3D polymerase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)" EXACT [GOC:TermGenie]
synonym: "inhibition of PB1 proteins" RELATED [GOC:TermGenie]
synonym: "inhibition of PB2 proteins" RELATED [GOC:TermGenie]
synonym: "inhibition of phage f2 replicase" NARROW [GOC:TermGenie]
synonym: "inhibition of polymerase L" RELATED [GOC:TermGenie]
synonym: "inhibition of Q-beta replicase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of RDRP" RELATED [GOC:TermGenie]
synonym: "inhibition of ribonucleic acid replicase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of ribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of ribonucleic replicase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of ribonucleic synthetase activity" RELATED [GOC:TermGenie]
synonym: "inhibition of RNA nucleotidyltransferase (RNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "inhibition of RNA replicase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of RNA synthetase activity" RELATED [GOC:TermGenie]
synonym: "inhibition of RNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of RNA-dependent RNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of RNA-dependent RNA replicase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of RNA-directed RNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of transcriptase" BROAD [GOC:TermGenie]
synonym: "negative regulation of 3D polymerase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)" EXACT [GOC:TermGenie]
synonym: "negative regulation of PB1 proteins" RELATED [GOC:TermGenie]
synonym: "negative regulation of PB2 proteins" RELATED [GOC:TermGenie]
synonym: "negative regulation of phage f2 replicase" NARROW [GOC:TermGenie]
synonym: "negative regulation of polymerase L" RELATED [GOC:TermGenie]
synonym: "negative regulation of Q-beta replicase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of RDRP" RELATED [GOC:TermGenie]
synonym: "negative regulation of ribonucleic acid replicase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of ribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of ribonucleic replicase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of ribonucleic synthetase activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of RNA nucleotidyltransferase (RNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of RNA replicase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of RNA synthetase activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of RNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of RNA-dependent RNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of RNA-dependent RNA replicase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of transcriptase" BROAD [GOC:TermGenie]
is_a: GO:0051348 ! negative regulation of transferase activity
is_a: GO:1900259 ! regulation of RNA-directed RNA polymerase activity
is_a: GO:1903507 ! negative regulation of nucleic acid-templated transcription
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003968 ! RNA-directed RNA polymerase activity
relationship: negatively_regulates GO:0003968 ! RNA-directed RNA polymerase activity
created_by: tb
creation_date: 2012-04-03T11:02:03Z

[Term]
id: GO:1900261
name: positive regulation of RNA-directed RNA polymerase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of RNA-directed RNA polymerase activity." [GOC:TermGenie]
synonym: "activation of 3D polymerase activity" EXACT [GOC:TermGenie]
synonym: "activation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)" EXACT [GOC:TermGenie]
synonym: "activation of PB1 proteins" RELATED [GOC:TermGenie]
synonym: "activation of PB2 proteins" RELATED [GOC:TermGenie]
synonym: "activation of phage f2 replicase" NARROW [GOC:TermGenie]
synonym: "activation of polymerase L" RELATED [GOC:TermGenie]
synonym: "activation of Q-beta replicase activity" EXACT [GOC:TermGenie]
synonym: "activation of RDRP" RELATED [GOC:TermGenie]
synonym: "activation of ribonucleic acid replicase activity" EXACT [GOC:TermGenie]
synonym: "activation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "activation of ribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [GOC:TermGenie]
synonym: "activation of ribonucleic replicase activity" EXACT [GOC:TermGenie]
synonym: "activation of ribonucleic synthetase activity" RELATED [GOC:TermGenie]
synonym: "activation of RNA nucleotidyltransferase (RNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "activation of RNA replicase activity" EXACT [GOC:TermGenie]
synonym: "activation of RNA synthetase activity" RELATED [GOC:TermGenie]
synonym: "activation of RNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "activation of RNA-dependent RNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "activation of RNA-dependent RNA replicase activity" EXACT [GOC:TermGenie]
synonym: "activation of RNA-directed RNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "activation of transcriptase" BROAD [GOC:TermGenie]
synonym: "positive regulation of 3D polymerase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)" EXACT [GOC:TermGenie]
synonym: "positive regulation of PB1 proteins" RELATED [GOC:TermGenie]
synonym: "positive regulation of PB2 proteins" RELATED [GOC:TermGenie]
synonym: "positive regulation of phage f2 replicase" NARROW [GOC:TermGenie]
synonym: "positive regulation of polymerase L" RELATED [GOC:TermGenie]
synonym: "positive regulation of Q-beta replicase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of RDRP" RELATED [GOC:TermGenie]
synonym: "positive regulation of ribonucleic acid replicase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of ribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of ribonucleic replicase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of ribonucleic synthetase activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of RNA nucleotidyltransferase (RNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of RNA replicase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of RNA synthetase activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of RNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of RNA-dependent RNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of RNA-dependent RNA replicase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcriptase" BROAD [GOC:TermGenie]
synonym: "up regulation of 3D polymerase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)" EXACT [GOC:TermGenie]
synonym: "up regulation of PB1 proteins" RELATED [GOC:TermGenie]
synonym: "up regulation of PB2 proteins" RELATED [GOC:TermGenie]
synonym: "up regulation of phage f2 replicase" NARROW [GOC:TermGenie]
synonym: "up regulation of polymerase L" RELATED [GOC:TermGenie]
synonym: "up regulation of Q-beta replicase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of RDRP" RELATED [GOC:TermGenie]
synonym: "up regulation of ribonucleic acid replicase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of ribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of ribonucleic replicase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of ribonucleic synthetase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of RNA nucleotidyltransferase (RNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "up regulation of RNA replicase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of RNA synthetase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of RNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of RNA-dependent RNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of RNA-dependent RNA replicase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of RNA-directed RNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of transcriptase" BROAD [GOC:TermGenie]
synonym: "up-regulation of 3D polymerase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)" EXACT [GOC:TermGenie]
synonym: "up-regulation of PB1 proteins" RELATED [GOC:TermGenie]
synonym: "up-regulation of PB2 proteins" RELATED [GOC:TermGenie]
synonym: "up-regulation of phage f2 replicase" NARROW [GOC:TermGenie]
synonym: "up-regulation of polymerase L" RELATED [GOC:TermGenie]
synonym: "up-regulation of Q-beta replicase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of RDRP" RELATED [GOC:TermGenie]
synonym: "up-regulation of ribonucleic acid replicase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of ribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of ribonucleic replicase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of ribonucleic synthetase activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of RNA nucleotidyltransferase (RNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNA replicase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNA synthetase activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of RNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNA-dependent RNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNA-dependent RNA replicase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNA-directed RNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of transcriptase" BROAD [GOC:TermGenie]
synonym: "upregulation of 3D polymerase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)" EXACT [GOC:TermGenie]
synonym: "upregulation of PB1 proteins" RELATED [GOC:TermGenie]
synonym: "upregulation of PB2 proteins" RELATED [GOC:TermGenie]
synonym: "upregulation of phage f2 replicase" NARROW [GOC:TermGenie]
synonym: "upregulation of polymerase L" RELATED [GOC:TermGenie]
synonym: "upregulation of Q-beta replicase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of RDRP" RELATED [GOC:TermGenie]
synonym: "upregulation of ribonucleic acid replicase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of ribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of ribonucleic replicase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of ribonucleic synthetase activity" RELATED [GOC:TermGenie]
synonym: "upregulation of RNA nucleotidyltransferase (RNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA replicase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA synthetase activity" RELATED [GOC:TermGenie]
synonym: "upregulation of RNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA-dependent RNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA-dependent RNA replicase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA-directed RNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of transcriptase" BROAD [GOC:TermGenie]
is_a: GO:0051347 ! positive regulation of transferase activity
is_a: GO:1900259 ! regulation of RNA-directed RNA polymerase activity
is_a: GO:1903508 ! positive regulation of nucleic acid-templated transcription
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003968 ! RNA-directed RNA polymerase activity
relationship: positively_regulates GO:0003968 ! RNA-directed RNA polymerase activity
created_by: tb
creation_date: 2012-04-03T11:02:11Z

[Term]
id: GO:1900262
name: regulation of DNA-directed DNA polymerase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA-directed DNA polymerase activity." [GOC:TermGenie]
synonym: "regulation of alpha DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "regulation of beta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "regulation of delta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "regulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "regulation of deoxyribonucleic acid duplicase activity" EXACT [GOC:TermGenie]
synonym: "regulation of deoxyribonucleic duplicase activity" EXACT [GOC:TermGenie]
synonym: "regulation of deoxyribonucleic polymerase I" NARROW [GOC:TermGenie]
synonym: "regulation of DNA duplicase activity" EXACT [GOC:TermGenie]
synonym: "regulation of DNA nucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "regulation of DNA polymerase alpha" NARROW [GOC:TermGenie]
synonym: "regulation of DNA polymerase beta" NARROW [GOC:TermGenie]
synonym: "regulation of DNA polymerase gamma" NARROW [GOC:TermGenie]
synonym: "regulation of DNA polymerase I" NARROW [GOC:TermGenie]
synonym: "regulation of DNA polymerase II" NARROW [GOC:TermGenie]
synonym: "regulation of DNA polymerase III" NARROW [GOC:TermGenie]
synonym: "regulation of DNA polymerase V activity" NARROW [GOC:TermGenie]
synonym: "regulation of DNA replicase activity" EXACT [GOC:TermGenie]
synonym: "regulation of DNA-dependent DNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "regulation of duplicase" BROAD [GOC:TermGenie]
synonym: "regulation of epsilon DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "regulation of eta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "regulation of gamma DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "regulation of iota DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "regulation of kappa DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "regulation of Klenow fragment" NARROW [GOC:TermGenie]
synonym: "regulation of lambda DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "regulation of mu DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "regulation of nu DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "regulation of sequenase" RELATED [GOC:TermGenie]
synonym: "regulation of sigma DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "regulation of Taq DNA polymerase" NARROW [GOC:TermGenie]
synonym: "regulation of Taq Pol I" NARROW [GOC:TermGenie]
synonym: "regulation of Tca DNA polymerase" NARROW [GOC:TermGenie]
synonym: "regulation of theta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "regulation of zeta DNA polymerase activity" NARROW [GOC:TermGenie]
is_a: GO:0051338 ! regulation of transferase activity
is_a: GO:0090329 ! regulation of DNA-dependent DNA replication
is_a: GO:2000278 ! regulation of DNA biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003887 ! DNA-directed DNA polymerase activity
relationship: regulates GO:0003887 ! DNA-directed DNA polymerase activity
created_by: tb
creation_date: 2012-04-03T11:07:08Z

[Term]
id: GO:1900263
name: negative regulation of DNA-directed DNA polymerase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA-directed DNA polymerase activity." [GOC:TermGenie]
synonym: "down regulation of alpha DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of beta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of delta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "down regulation of deoxyribonucleic acid duplicase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of deoxyribonucleic duplicase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of deoxyribonucleic polymerase I" NARROW [GOC:TermGenie]
synonym: "down regulation of DNA duplicase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of DNA nucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "down regulation of DNA polymerase alpha" NARROW [GOC:TermGenie]
synonym: "down regulation of DNA polymerase beta" NARROW [GOC:TermGenie]
synonym: "down regulation of DNA polymerase gamma" NARROW [GOC:TermGenie]
synonym: "down regulation of DNA polymerase I" NARROW [GOC:TermGenie]
synonym: "down regulation of DNA polymerase II" NARROW [GOC:TermGenie]
synonym: "down regulation of DNA polymerase III" NARROW [GOC:TermGenie]
synonym: "down regulation of DNA polymerase V activity" NARROW [GOC:TermGenie]
synonym: "down regulation of DNA replicase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of DNA-dependent DNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of DNA-directed DNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of duplicase" BROAD [GOC:TermGenie]
synonym: "down regulation of epsilon DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of eta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of gamma DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of iota DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of kappa DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of Klenow fragment" NARROW [GOC:TermGenie]
synonym: "down regulation of lambda DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of mu DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of nu DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of sequenase" RELATED [GOC:TermGenie]
synonym: "down regulation of sigma DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of Taq DNA polymerase" NARROW [GOC:TermGenie]
synonym: "down regulation of Taq Pol I" NARROW [GOC:TermGenie]
synonym: "down regulation of Tca DNA polymerase" NARROW [GOC:TermGenie]
synonym: "down regulation of theta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of zeta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of alpha DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of beta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of delta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of deoxyribonucleic acid duplicase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of deoxyribonucleic duplicase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of deoxyribonucleic polymerase I" NARROW [GOC:TermGenie]
synonym: "down-regulation of DNA duplicase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA nucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA polymerase alpha" NARROW [GOC:TermGenie]
synonym: "down-regulation of DNA polymerase beta" NARROW [GOC:TermGenie]
synonym: "down-regulation of DNA polymerase gamma" NARROW [GOC:TermGenie]
synonym: "down-regulation of DNA polymerase I" NARROW [GOC:TermGenie]
synonym: "down-regulation of DNA polymerase II" NARROW [GOC:TermGenie]
synonym: "down-regulation of DNA polymerase III" NARROW [GOC:TermGenie]
synonym: "down-regulation of DNA polymerase V activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of DNA replicase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA-dependent DNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA-directed DNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of duplicase" BROAD [GOC:TermGenie]
synonym: "down-regulation of epsilon DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of eta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of gamma DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of iota DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of kappa DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of Klenow fragment" NARROW [GOC:TermGenie]
synonym: "down-regulation of lambda DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of mu DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of nu DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of sequenase" RELATED [GOC:TermGenie]
synonym: "down-regulation of sigma DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of Taq DNA polymerase" NARROW [GOC:TermGenie]
synonym: "down-regulation of Taq Pol I" NARROW [GOC:TermGenie]
synonym: "down-regulation of Tca DNA polymerase" NARROW [GOC:TermGenie]
synonym: "down-regulation of theta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of zeta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of alpha DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of beta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of delta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "downregulation of deoxyribonucleic acid duplicase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of deoxyribonucleic duplicase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of deoxyribonucleic polymerase I" NARROW [GOC:TermGenie]
synonym: "downregulation of DNA duplicase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA nucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA polymerase alpha" NARROW [GOC:TermGenie]
synonym: "downregulation of DNA polymerase beta" NARROW [GOC:TermGenie]
synonym: "downregulation of DNA polymerase gamma" NARROW [GOC:TermGenie]
synonym: "downregulation of DNA polymerase I" NARROW [GOC:TermGenie]
synonym: "downregulation of DNA polymerase II" NARROW [GOC:TermGenie]
synonym: "downregulation of DNA polymerase III" NARROW [GOC:TermGenie]
synonym: "downregulation of DNA polymerase V activity" NARROW [GOC:TermGenie]
synonym: "downregulation of DNA replicase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA-dependent DNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA-directed DNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of duplicase" BROAD [GOC:TermGenie]
synonym: "downregulation of epsilon DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of eta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of gamma DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of iota DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of kappa DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of Klenow fragment" NARROW [GOC:TermGenie]
synonym: "downregulation of lambda DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of mu DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of nu DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of sequenase" RELATED [GOC:TermGenie]
synonym: "downregulation of sigma DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of Taq DNA polymerase" NARROW [GOC:TermGenie]
synonym: "downregulation of Taq Pol I" NARROW [GOC:TermGenie]
synonym: "downregulation of Tca DNA polymerase" NARROW [GOC:TermGenie]
synonym: "downregulation of theta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of zeta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of alpha DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of beta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of delta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "inhibition of deoxyribonucleic acid duplicase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of deoxyribonucleic duplicase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of deoxyribonucleic polymerase I" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA duplicase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of DNA nucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "inhibition of DNA polymerase alpha" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA polymerase beta" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA polymerase gamma" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA polymerase I" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA polymerase II" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA polymerase III" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA polymerase V activity" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA replicase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of DNA-dependent DNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of duplicase" BROAD [GOC:TermGenie]
synonym: "inhibition of epsilon DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of eta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of gamma DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of iota DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of kappa DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of Klenow fragment" NARROW [GOC:TermGenie]
synonym: "inhibition of lambda DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of mu DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of nu DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of sequenase" RELATED [GOC:TermGenie]
synonym: "inhibition of sigma DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of Taq DNA polymerase" NARROW [GOC:TermGenie]
synonym: "inhibition of Taq Pol I" NARROW [GOC:TermGenie]
synonym: "inhibition of Tca DNA polymerase" NARROW [GOC:TermGenie]
synonym: "inhibition of theta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of zeta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of alpha DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of beta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of delta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of deoxyribonucleic acid duplicase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of deoxyribonucleic duplicase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of deoxyribonucleic polymerase I" NARROW [GOC:TermGenie]
synonym: "negative regulation of DNA duplicase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of DNA nucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of DNA polymerase alpha" NARROW [GOC:TermGenie]
synonym: "negative regulation of DNA polymerase beta" NARROW [GOC:TermGenie]
synonym: "negative regulation of DNA polymerase gamma" NARROW [GOC:TermGenie]
synonym: "negative regulation of DNA polymerase I" NARROW [GOC:TermGenie]
synonym: "negative regulation of DNA polymerase II" NARROW [GOC:TermGenie]
synonym: "negative regulation of DNA polymerase III" NARROW [GOC:TermGenie]
synonym: "negative regulation of DNA polymerase V activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of DNA replicase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of DNA-dependent DNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of duplicase" BROAD [GOC:TermGenie]
synonym: "negative regulation of epsilon DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of eta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of gamma DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of iota DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of kappa DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of Klenow fragment" NARROW [GOC:TermGenie]
synonym: "negative regulation of lambda DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of mu DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of nu DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of sequenase" RELATED [GOC:TermGenie]
synonym: "negative regulation of sigma DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of Taq DNA polymerase" NARROW [GOC:TermGenie]
synonym: "negative regulation of Taq Pol I" NARROW [GOC:TermGenie]
synonym: "negative regulation of Tca DNA polymerase" NARROW [GOC:TermGenie]
synonym: "negative regulation of theta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of zeta DNA polymerase activity" NARROW [GOC:TermGenie]
is_a: GO:0051348 ! negative regulation of transferase activity
is_a: GO:1900262 ! regulation of DNA-directed DNA polymerase activity
is_a: GO:2000279 ! negative regulation of DNA biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003887 ! DNA-directed DNA polymerase activity
relationship: negatively_regulates GO:0003887 ! DNA-directed DNA polymerase activity
created_by: tb
creation_date: 2012-04-03T11:07:18Z

[Term]
id: GO:1900264
name: positive regulation of DNA-directed DNA polymerase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA-directed DNA polymerase activity." [GOC:TermGenie]
synonym: "activation of alpha DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "activation of beta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "activation of delta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "activation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "activation of deoxyribonucleic acid duplicase activity" EXACT [GOC:TermGenie]
synonym: "activation of deoxyribonucleic duplicase activity" EXACT [GOC:TermGenie]
synonym: "activation of deoxyribonucleic polymerase I" NARROW [GOC:TermGenie]
synonym: "activation of DNA duplicase activity" EXACT [GOC:TermGenie]
synonym: "activation of DNA nucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "activation of DNA polymerase alpha" NARROW [GOC:TermGenie]
synonym: "activation of DNA polymerase beta" NARROW [GOC:TermGenie]
synonym: "activation of DNA polymerase gamma" NARROW [GOC:TermGenie]
synonym: "activation of DNA polymerase I" NARROW [GOC:TermGenie]
synonym: "activation of DNA polymerase II" NARROW [GOC:TermGenie]
synonym: "activation of DNA polymerase III" NARROW [GOC:TermGenie]
synonym: "activation of DNA polymerase V activity" NARROW [GOC:TermGenie]
synonym: "activation of DNA replicase activity" EXACT [GOC:TermGenie]
synonym: "activation of DNA-dependent DNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "activation of DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "activation of duplicase" BROAD [GOC:TermGenie]
synonym: "activation of epsilon DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "activation of eta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "activation of gamma DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "activation of iota DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "activation of kappa DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "activation of Klenow fragment" NARROW [GOC:TermGenie]
synonym: "activation of lambda DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "activation of mu DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "activation of nu DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "activation of sequenase" RELATED [GOC:TermGenie]
synonym: "activation of sigma DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "activation of Taq DNA polymerase" NARROW [GOC:TermGenie]
synonym: "activation of Taq Pol I" NARROW [GOC:TermGenie]
synonym: "activation of Tca DNA polymerase" NARROW [GOC:TermGenie]
synonym: "activation of theta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "activation of zeta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of alpha DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of beta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of delta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of deoxyribonucleic acid duplicase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of deoxyribonucleic duplicase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of deoxyribonucleic polymerase I" NARROW [GOC:TermGenie]
synonym: "positive regulation of DNA duplicase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of DNA nucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of DNA polymerase alpha" NARROW [GOC:TermGenie]
synonym: "positive regulation of DNA polymerase beta" NARROW [GOC:TermGenie]
synonym: "positive regulation of DNA polymerase gamma" NARROW [GOC:TermGenie]
synonym: "positive regulation of DNA polymerase I" NARROW [GOC:TermGenie]
synonym: "positive regulation of DNA polymerase II" NARROW [GOC:TermGenie]
synonym: "positive regulation of DNA polymerase III" NARROW [GOC:TermGenie]
synonym: "positive regulation of DNA polymerase V activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of DNA replicase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of DNA-dependent DNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of duplicase" BROAD [GOC:TermGenie]
synonym: "positive regulation of epsilon DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of eta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of gamma DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of iota DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of kappa DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of Klenow fragment" NARROW [GOC:TermGenie]
synonym: "positive regulation of lambda DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of mu DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of nu DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of sequenase" RELATED [GOC:TermGenie]
synonym: "positive regulation of sigma DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of Taq DNA polymerase" NARROW [GOC:TermGenie]
synonym: "positive regulation of Taq Pol I" NARROW [GOC:TermGenie]
synonym: "positive regulation of Tca DNA polymerase" NARROW [GOC:TermGenie]
synonym: "positive regulation of theta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of zeta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of alpha DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of beta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of delta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "up regulation of deoxyribonucleic acid duplicase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of deoxyribonucleic duplicase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of deoxyribonucleic polymerase I" NARROW [GOC:TermGenie]
synonym: "up regulation of DNA duplicase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA nucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA polymerase alpha" NARROW [GOC:TermGenie]
synonym: "up regulation of DNA polymerase beta" NARROW [GOC:TermGenie]
synonym: "up regulation of DNA polymerase gamma" NARROW [GOC:TermGenie]
synonym: "up regulation of DNA polymerase I" NARROW [GOC:TermGenie]
synonym: "up regulation of DNA polymerase II" NARROW [GOC:TermGenie]
synonym: "up regulation of DNA polymerase III" NARROW [GOC:TermGenie]
synonym: "up regulation of DNA polymerase V activity" NARROW [GOC:TermGenie]
synonym: "up regulation of DNA replicase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA-dependent DNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA-directed DNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of duplicase" BROAD [GOC:TermGenie]
synonym: "up regulation of epsilon DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of eta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of gamma DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of iota DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of kappa DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of Klenow fragment" NARROW [GOC:TermGenie]
synonym: "up regulation of lambda DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of mu DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of nu DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of sequenase" RELATED [GOC:TermGenie]
synonym: "up regulation of sigma DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of Taq DNA polymerase" NARROW [GOC:TermGenie]
synonym: "up regulation of Taq Pol I" NARROW [GOC:TermGenie]
synonym: "up regulation of Tca DNA polymerase" NARROW [GOC:TermGenie]
synonym: "up regulation of theta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of zeta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of alpha DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of beta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of delta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of deoxyribonucleic acid duplicase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of deoxyribonucleic duplicase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of deoxyribonucleic polymerase I" NARROW [GOC:TermGenie]
synonym: "up-regulation of DNA duplicase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA nucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA polymerase alpha" NARROW [GOC:TermGenie]
synonym: "up-regulation of DNA polymerase beta" NARROW [GOC:TermGenie]
synonym: "up-regulation of DNA polymerase gamma" NARROW [GOC:TermGenie]
synonym: "up-regulation of DNA polymerase I" NARROW [GOC:TermGenie]
synonym: "up-regulation of DNA polymerase II" NARROW [GOC:TermGenie]
synonym: "up-regulation of DNA polymerase III" NARROW [GOC:TermGenie]
synonym: "up-regulation of DNA polymerase V activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of DNA replicase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA-dependent DNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA-directed DNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of duplicase" BROAD [GOC:TermGenie]
synonym: "up-regulation of epsilon DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of eta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of gamma DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of iota DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of kappa DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of Klenow fragment" NARROW [GOC:TermGenie]
synonym: "up-regulation of lambda DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of mu DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of nu DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of sequenase" RELATED [GOC:TermGenie]
synonym: "up-regulation of sigma DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of Taq DNA polymerase" NARROW [GOC:TermGenie]
synonym: "up-regulation of Taq Pol I" NARROW [GOC:TermGenie]
synonym: "up-regulation of Tca DNA polymerase" NARROW [GOC:TermGenie]
synonym: "up-regulation of theta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of zeta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of alpha DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of beta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of delta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "upregulation of deoxyribonucleic acid duplicase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of deoxyribonucleic duplicase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of deoxyribonucleic polymerase I" NARROW [GOC:TermGenie]
synonym: "upregulation of DNA duplicase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA nucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA polymerase alpha" NARROW [GOC:TermGenie]
synonym: "upregulation of DNA polymerase beta" NARROW [GOC:TermGenie]
synonym: "upregulation of DNA polymerase gamma" NARROW [GOC:TermGenie]
synonym: "upregulation of DNA polymerase I" NARROW [GOC:TermGenie]
synonym: "upregulation of DNA polymerase II" NARROW [GOC:TermGenie]
synonym: "upregulation of DNA polymerase III" NARROW [GOC:TermGenie]
synonym: "upregulation of DNA polymerase V activity" NARROW [GOC:TermGenie]
synonym: "upregulation of DNA replicase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA-dependent DNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA-directed DNA polymerase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of duplicase" BROAD [GOC:TermGenie]
synonym: "upregulation of epsilon DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of eta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of gamma DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of iota DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of kappa DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of Klenow fragment" NARROW [GOC:TermGenie]
synonym: "upregulation of lambda DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of mu DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of nu DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of sequenase" RELATED [GOC:TermGenie]
synonym: "upregulation of sigma DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of Taq DNA polymerase" NARROW [GOC:TermGenie]
synonym: "upregulation of Taq Pol I" NARROW [GOC:TermGenie]
synonym: "upregulation of Tca DNA polymerase" NARROW [GOC:TermGenie]
synonym: "upregulation of theta DNA polymerase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of zeta DNA polymerase activity" NARROW [GOC:TermGenie]
is_a: GO:0051347 ! positive regulation of transferase activity
is_a: GO:1900262 ! regulation of DNA-directed DNA polymerase activity
is_a: GO:2000573 ! positive regulation of DNA biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003887 ! DNA-directed DNA polymerase activity
relationship: positively_regulates GO:0003887 ! DNA-directed DNA polymerase activity
created_by: tb
creation_date: 2012-04-03T11:07:27Z

[Term]
id: GO:1900265
name: regulation of substance P receptor binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of substance P receptor binding." [GOC:TermGenie]
synonym: "regulation of neurokinin-1 receptor binding" EXACT [GOC:TermGenie]
synonym: "regulation of substance P receptor ligand" NARROW [GOC:TermGenie]
is_a: GO:1900120 ! regulation of receptor binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031835 ! substance P receptor binding
relationship: regulates GO:0031835 ! substance P receptor binding
created_by: tb
creation_date: 2012-04-03T11:11:27Z

[Term]
id: GO:1900266
name: negative regulation of substance P receptor binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of substance P receptor binding." [GOC:TermGenie]
synonym: "down regulation of neurokinin-1 receptor binding" EXACT [GOC:TermGenie]
synonym: "down regulation of substance P receptor binding" EXACT [GOC:TermGenie]
synonym: "down regulation of substance P receptor ligand" NARROW [GOC:TermGenie]
synonym: "down-regulation of neurokinin-1 receptor binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of substance P receptor binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of substance P receptor ligand" NARROW [GOC:TermGenie]
synonym: "downregulation of neurokinin-1 receptor binding" EXACT [GOC:TermGenie]
synonym: "downregulation of substance P receptor binding" EXACT [GOC:TermGenie]
synonym: "downregulation of substance P receptor ligand" NARROW [GOC:TermGenie]
synonym: "inhibition of neurokinin-1 receptor binding" EXACT [GOC:TermGenie]
synonym: "inhibition of substance P receptor binding" NARROW [GOC:TermGenie]
synonym: "inhibition of substance P receptor ligand" NARROW [GOC:TermGenie]
synonym: "negative regulation of neurokinin-1 receptor binding" EXACT [GOC:TermGenie]
synonym: "negative regulation of substance P receptor ligand" NARROW [GOC:TermGenie]
is_a: GO:1900121 ! negative regulation of receptor binding
is_a: GO:1900265 ! regulation of substance P receptor binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0031835 ! substance P receptor binding
relationship: negatively_regulates GO:0031835 ! substance P receptor binding
created_by: tb
creation_date: 2012-04-03T11:11:36Z

[Term]
id: GO:1900267
name: positive regulation of substance P receptor binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of substance P receptor binding." [GOC:TermGenie]
synonym: "activation of neurokinin-1 receptor binding" EXACT [GOC:TermGenie]
synonym: "activation of substance P receptor binding" NARROW [GOC:TermGenie]
synonym: "activation of substance P receptor ligand" NARROW [GOC:TermGenie]
synonym: "positive regulation of neurokinin-1 receptor binding" EXACT [GOC:TermGenie]
synonym: "positive regulation of substance P receptor ligand" NARROW [GOC:TermGenie]
synonym: "up regulation of neurokinin-1 receptor binding" EXACT [GOC:TermGenie]
synonym: "up regulation of substance P receptor binding" EXACT [GOC:TermGenie]
synonym: "up regulation of substance P receptor ligand" NARROW [GOC:TermGenie]
synonym: "up-regulation of neurokinin-1 receptor binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of substance P receptor binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of substance P receptor ligand" NARROW [GOC:TermGenie]
synonym: "upregulation of neurokinin-1 receptor binding" EXACT [GOC:TermGenie]
synonym: "upregulation of substance P receptor binding" EXACT [GOC:TermGenie]
synonym: "upregulation of substance P receptor ligand" NARROW [GOC:TermGenie]
is_a: GO:1900122 ! positive regulation of receptor binding
is_a: GO:1900265 ! regulation of substance P receptor binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0031835 ! substance P receptor binding
relationship: positively_regulates GO:0031835 ! substance P receptor binding
created_by: tb
creation_date: 2012-04-03T11:11:45Z

[Term]
id: GO:1900268
name: regulation of reverse transcription
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of reverse transcription." [GOC:TermGenie]
is_a: GO:0006275 ! regulation of DNA replication
is_a: GO:2000278 ! regulation of DNA biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001171 ! reverse transcription
relationship: regulates GO:0001171 ! reverse transcription
created_by: tb
creation_date: 2012-04-03T11:13:26Z

[Term]
id: GO:1900269
name: negative regulation of reverse transcription
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of reverse transcription." [GOC:TermGenie]
synonym: "down regulation of reverse transcription" EXACT [GOC:TermGenie]
synonym: "down-regulation of reverse transcription" EXACT [GOC:TermGenie]
synonym: "downregulation of reverse transcription" EXACT [GOC:TermGenie]
synonym: "inhibition of reverse transcription" NARROW [GOC:TermGenie]
is_a: GO:0008156 ! negative regulation of DNA replication
is_a: GO:1900268 ! regulation of reverse transcription
is_a: GO:2000279 ! negative regulation of DNA biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001171 ! reverse transcription
relationship: negatively_regulates GO:0001171 ! reverse transcription
created_by: tb
creation_date: 2012-04-03T11:13:35Z

[Term]
id: GO:1900270
name: positive regulation of reverse transcription
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of reverse transcription." [GOC:TermGenie]
synonym: "activation of reverse transcription" NARROW [GOC:TermGenie]
synonym: "up regulation of reverse transcription" EXACT [GOC:TermGenie]
synonym: "up-regulation of reverse transcription" EXACT [GOC:TermGenie]
synonym: "upregulation of reverse transcription" EXACT [GOC:TermGenie]
is_a: GO:0045740 ! positive regulation of DNA replication
is_a: GO:1900268 ! regulation of reverse transcription
is_a: GO:2000573 ! positive regulation of DNA biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001171 ! reverse transcription
relationship: positively_regulates GO:0001171 ! reverse transcription
created_by: tb
creation_date: 2012-04-03T11:13:43Z

[Term]
id: GO:1900271
name: regulation of long-term synaptic potentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of long-term synaptic potentiation." [GOC:BHF, GOC:TermGenie]
synonym: "regulation of long-term potentiation" BROAD [GOC:TermGenie]
synonym: "regulation of LTP" RELATED [GOC:TermGenie]
is_a: GO:0048167 ! regulation of synaptic plasticity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060291 ! long-term synaptic potentiation
relationship: regulates GO:0060291 ! long-term synaptic potentiation
created_by: rl
creation_date: 2012-04-04T07:17:13Z

[Term]
id: GO:1900272
name: negative regulation of long-term synaptic potentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of long-term synaptic potentiation." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of long-term potentiation" BROAD [GOC:TermGenie]
synonym: "down regulation of long-term synaptic potentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of LTP" RELATED [GOC:TermGenie]
synonym: "down-regulation of long-term potentiation" BROAD [GOC:TermGenie]
synonym: "down-regulation of long-term synaptic potentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of LTP" RELATED [GOC:TermGenie]
synonym: "downregulation of long-term potentiation" BROAD [GOC:TermGenie]
synonym: "downregulation of long-term synaptic potentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of LTP" RELATED [GOC:TermGenie]
synonym: "inhibition of long-term potentiation" BROAD [GOC:TermGenie]
synonym: "inhibition of long-term synaptic potentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of LTP" RELATED [GOC:TermGenie]
synonym: "negative regulation of long-term potentiation" BROAD [GOC:TermGenie]
synonym: "negative regulation of LTP" RELATED [GOC:TermGenie]
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:1900271 ! regulation of long-term synaptic potentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060291 ! long-term synaptic potentiation
relationship: negatively_regulates GO:0060291 ! long-term synaptic potentiation
created_by: rl
creation_date: 2012-04-04T07:17:21Z

[Term]
id: GO:1900273
name: positive regulation of long-term synaptic potentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of long-term synaptic potentiation." [GOC:BHF, GOC:TermGenie]
synonym: "activation of long-term potentiation" BROAD [GOC:TermGenie]
synonym: "activation of long-term synaptic potentiation" NARROW [GOC:TermGenie]
synonym: "activation of LTP" RELATED [GOC:TermGenie]
synonym: "positive regulation of long-term potentiation" BROAD [GOC:TermGenie]
synonym: "positive regulation of LTP" RELATED [GOC:TermGenie]
synonym: "up regulation of long-term potentiation" BROAD [GOC:TermGenie]
synonym: "up regulation of long-term synaptic potentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of LTP" RELATED [GOC:TermGenie]
synonym: "up-regulation of long-term potentiation" BROAD [GOC:TermGenie]
synonym: "up-regulation of long-term synaptic potentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of LTP" RELATED [GOC:TermGenie]
synonym: "upregulation of long-term potentiation" BROAD [GOC:TermGenie]
synonym: "upregulation of long-term synaptic potentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of LTP" RELATED [GOC:TermGenie]
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:1900271 ! regulation of long-term synaptic potentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060291 ! long-term synaptic potentiation
relationship: positively_regulates GO:0060291 ! long-term synaptic potentiation
created_by: rl
creation_date: 2012-04-04T07:17:30Z

[Term]
id: GO:1900274
name: regulation of phospholipase C activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phospholipase C activity." [GOC:BHF, GOC:TermGenie]
synonym: "regulation of lecithinase C activity" RELATED [GOC:TermGenie]
synonym: "regulation of lipophosphodiesterase C" RELATED [GOC:TermGenie]
synonym: "regulation of phosphatidase C" RELATED [GOC:TermGenie]
is_a: GO:0010517 ! regulation of phospholipase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004629 ! phospholipase C activity
relationship: regulates GO:0004629 ! phospholipase C activity
created_by: rl
creation_date: 2012-04-04T01:19:00Z

[Term]
id: GO:1900275
name: negative regulation of phospholipase C activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of phospholipase C activity." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of lecithinase C activity" RELATED [GOC:TermGenie]
synonym: "down regulation of lipophosphodiesterase C" RELATED [GOC:TermGenie]
synonym: "down regulation of phosphatidase C" RELATED [GOC:TermGenie]
synonym: "down regulation of phospholipase C activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of lecithinase C activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of lipophosphodiesterase C" RELATED [GOC:TermGenie]
synonym: "down-regulation of phosphatidase C" RELATED [GOC:TermGenie]
synonym: "down-regulation of phospholipase C activity" EXACT [GOC:TermGenie]
synonym: "downregulation of lecithinase C activity" RELATED [GOC:TermGenie]
synonym: "downregulation of lipophosphodiesterase C" RELATED [GOC:TermGenie]
synonym: "downregulation of phosphatidase C" RELATED [GOC:TermGenie]
synonym: "downregulation of phospholipase C activity" EXACT [GOC:TermGenie]
synonym: "inhibition of lecithinase C activity" RELATED [GOC:TermGenie]
synonym: "inhibition of lipophosphodiesterase C" RELATED [GOC:TermGenie]
synonym: "inhibition of phosphatidase C" RELATED [GOC:TermGenie]
synonym: "inhibition of phospholipase C activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of lecithinase C activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of lipophosphodiesterase C" RELATED [GOC:TermGenie]
synonym: "negative regulation of phosphatidase C" RELATED [GOC:TermGenie]
is_a: GO:0010519 ! negative regulation of phospholipase activity
is_a: GO:1900274 ! regulation of phospholipase C activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004629 ! phospholipase C activity
relationship: negatively_regulates GO:0004629 ! phospholipase C activity
created_by: rl
creation_date: 2012-04-04T01:19:10Z

[Term]
id: GO:1900276
name: regulation of proteinase activated receptor activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of proteinase activated receptor activity." [GOC:BHF, GOC:TermGenie]
is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:0010469 ! regulation of receptor activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001648 ! proteinase activated receptor activity
relationship: regulates GO:0001648 ! proteinase activated receptor activity
created_by: rl
creation_date: 2012-04-04T01:31:20Z

[Term]
id: GO:1900277
name: negative regulation of proteinase activated receptor activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of proteinase activated receptor activity." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of proteinase activated receptor activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of proteinase activated receptor activity" EXACT [GOC:TermGenie]
synonym: "downregulation of proteinase activated receptor activity" EXACT [GOC:TermGenie]
synonym: "inhibition of proteinase activated receptor activity" NARROW [GOC:TermGenie]
is_a: GO:0045744 ! negative regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:1900276 ! regulation of proteinase activated receptor activity
is_a: GO:2000272 ! negative regulation of receptor activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001648 ! proteinase activated receptor activity
relationship: negatively_regulates GO:0001648 ! proteinase activated receptor activity
created_by: rl
creation_date: 2012-04-04T01:31:29Z

[Term]
id: GO:1900278
name: positive regulation of proteinase activated receptor activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of proteinase activated receptor activity." [GOC:BHF, GOC:TermGenie]
synonym: "activation of proteinase activated receptor activity" NARROW [GOC:TermGenie]
synonym: "up regulation of proteinase activated receptor activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of proteinase activated receptor activity" EXACT [GOC:TermGenie]
synonym: "upregulation of proteinase activated receptor activity" EXACT [GOC:TermGenie]
is_a: GO:0045745 ! positive regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:1900276 ! regulation of proteinase activated receptor activity
is_a: GO:2000273 ! positive regulation of receptor activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001648 ! proteinase activated receptor activity
relationship: positively_regulates GO:0001648 ! proteinase activated receptor activity
created_by: rl
creation_date: 2012-04-04T01:31:37Z

[Term]
id: GO:1900279
name: regulation of CD4-positive, alpha-beta T cell costimulation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of CD4-positive, alpha-beta T cell costimulation." [GOC:BHF, GOC:pr, GOC:TermGenie]
synonym: "regulation of CD4-positive, alpha beta T cell costimulation" EXACT []
is_a: GO:2000514 ! regulation of CD4-positive, alpha-beta T cell activation
is_a: GO:2000523 ! regulation of T cell costimulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035783 ! CD4-positive, alpha-beta T cell costimulation
relationship: regulates GO:0035783 ! CD4-positive, alpha-beta T cell costimulation
created_by: rl
creation_date: 2012-04-04T08:56:15Z

[Term]
id: GO:1900280
name: negative regulation of CD4-positive, alpha-beta T cell costimulation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of CD4-positive, alpha-beta T cell costimulation." [GOC:BHF, GOC:pr, GOC:TermGenie]
synonym: "down regulation of CD4-positive, alpha beta T cell costimulation" EXACT [GOC:TermGenie]
synonym: "down-regulation of CD4-positive, alpha beta T cell costimulation" EXACT [GOC:TermGenie]
synonym: "downregulation of CD4-positive, alpha beta T cell costimulation" EXACT [GOC:TermGenie]
synonym: "inhibition of CD4-positive, alpha beta T cell costimulation" NARROW [GOC:TermGenie]
synonym: "negative regulation of CD4-positive, alpha beta T cell costimulation" EXACT []
is_a: GO:1900279 ! regulation of CD4-positive, alpha-beta T cell costimulation
is_a: GO:2000524 ! negative regulation of T cell costimulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035783 ! CD4-positive, alpha-beta T cell costimulation
relationship: negatively_regulates GO:0035783 ! CD4-positive, alpha-beta T cell costimulation
created_by: rl
creation_date: 2012-04-04T08:56:26Z

[Term]
id: GO:1900281
name: positive regulation of CD4-positive, alpha-beta T cell costimulation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell costimulation." [GOC:BHF, GOC:pr, GOC:TermGenie]
synonym: "activation of CD4-positive, alpha beta T cell costimulation" NARROW [GOC:TermGenie]
synonym: "positive regulation of CD4-positive, alpha beta T cell costimulation" EXACT []
synonym: "up regulation of CD4-positive, alpha beta T cell costimulation" EXACT [GOC:TermGenie]
synonym: "up-regulation of CD4-positive, alpha beta T cell costimulation" EXACT [GOC:TermGenie]
synonym: "upregulation of CD4-positive, alpha beta T cell costimulation" EXACT [GOC:TermGenie]
is_a: GO:1900279 ! regulation of CD4-positive, alpha-beta T cell costimulation
is_a: GO:2000525 ! positive regulation of T cell costimulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035783 ! CD4-positive, alpha-beta T cell costimulation
relationship: positively_regulates GO:0035783 ! CD4-positive, alpha-beta T cell costimulation
created_by: rl
creation_date: 2012-04-04T08:56:45Z

[Term]
id: GO:1900282
name: regulation of cellobiose catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellobiose catabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of cellobiose catabolism" EXACT [GOC:TermGenie]
is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process
is_a: GO:2000930 ! regulation of cellobiose metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:2000892 ! cellobiose catabolic process
relationship: regulates GO:2000892 ! cellobiose catabolic process
created_by: tt
creation_date: 2012-04-05T12:28:50Z

[Term]
id: GO:1900283
name: negative regulation of cellobiose catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellobiose catabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of cellobiose catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of cellobiose catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellobiose catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellobiose catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of cellobiose catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of cellobiose catabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of cellobiose catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of cellobiose catabolism" NARROW [GOC:TermGenie]
synonym: "negative regulation of cellobiose catabolism" EXACT [GOC:TermGenie]
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:1900282 ! regulation of cellobiose catabolic process
is_a: GO:2000931 ! negative regulation of cellobiose metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:2000892 ! cellobiose catabolic process
relationship: negatively_regulates GO:2000892 ! cellobiose catabolic process
created_by: tt
creation_date: 2012-04-05T12:29:00Z

[Term]
id: GO:1900284
name: positive regulation of cellobiose catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellobiose catabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of cellobiose catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of cellobiose catabolism" NARROW [GOC:TermGenie]
synonym: "positive regulation of cellobiose catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of cellobiose catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of cellobiose catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellobiose catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellobiose catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of cellobiose catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of cellobiose catabolism" EXACT [GOC:TermGenie]
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:1900282 ! regulation of cellobiose catabolic process
is_a: GO:2000932 ! positive regulation of cellobiose metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:2000892 ! cellobiose catabolic process
relationship: positively_regulates GO:2000892 ! cellobiose catabolic process
created_by: tt
creation_date: 2012-04-05T12:29:09Z

[Term]
id: GO:1900285
name: regulation of cellotriose transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellotriose transport." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:2001096 ! cellotriose transport
relationship: regulates GO:2001096 ! cellotriose transport
created_by: tt
creation_date: 2012-04-05T05:56:46Z

[Term]
id: GO:1900286
name: negative regulation of cellotriose transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellotriose transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of cellotriose transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellotriose transport" EXACT [GOC:TermGenie]
synonym: "downregulation of cellotriose transport" EXACT [GOC:TermGenie]
synonym: "inhibition of cellotriose transport" NARROW [GOC:TermGenie]
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:1900285 ! regulation of cellotriose transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:2001096 ! cellotriose transport
relationship: negatively_regulates GO:2001096 ! cellotriose transport
created_by: tt
creation_date: 2012-04-05T05:56:56Z

[Term]
id: GO:1900287
name: positive regulation of cellotriose transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellotriose transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of cellotriose transport" NARROW [GOC:TermGenie]
synonym: "up regulation of cellotriose transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellotriose transport" EXACT [GOC:TermGenie]
synonym: "upregulation of cellotriose transport" EXACT [GOC:TermGenie]
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:1900285 ! regulation of cellotriose transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:2001096 ! cellotriose transport
relationship: positively_regulates GO:2001096 ! cellotriose transport
created_by: tt
creation_date: 2012-04-05T05:57:05Z

[Term]
id: GO:1900288
name: regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of coenzyme F420-dependent bicyclic nitroimidazole catabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of coenzyme F420-dependent nitroimidazole breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of coenzyme F420-dependent nitroimidazole catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of coenzyme F420-dependent nitroimidazole reduction" EXACT [GOC:TermGenie]
synonym: "regulation of coenzyme F420-dependent nitroreductase activity" RELATED [GOC:TermGenie]
is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0052799 ! coenzyme F420-dependent bicyclic nitroimidazole catabolic process
relationship: regulates GO:0052799 ! coenzyme F420-dependent bicyclic nitroimidazole catabolic process
created_by: tt
creation_date: 2012-04-05T06:02:41Z

[Term]
id: GO:1900289
name: negative regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of coenzyme F420-dependent bicyclic nitroimidazole catabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of coenzyme F420-dependent nitroimidazole breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of coenzyme F420-dependent nitroimidazole catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of coenzyme F420-dependent nitroimidazole reduction" EXACT [GOC:TermGenie]
synonym: "down regulation of coenzyme F420-dependent nitroreductase activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of coenzyme F420-dependent nitroimidazole breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of coenzyme F420-dependent nitroimidazole catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of coenzyme F420-dependent nitroimidazole reduction" EXACT [GOC:TermGenie]
synonym: "down-regulation of coenzyme F420-dependent nitroreductase activity" RELATED [GOC:TermGenie]
synonym: "downregulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of coenzyme F420-dependent nitroimidazole breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of coenzyme F420-dependent nitroimidazole catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of coenzyme F420-dependent nitroimidazole reduction" EXACT [GOC:TermGenie]
synonym: "downregulation of coenzyme F420-dependent nitroreductase activity" RELATED [GOC:TermGenie]
synonym: "inhibition of coenzyme F420-dependent bicyclic nitroimidazole catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of coenzyme F420-dependent nitroimidazole breakdown" NARROW [GOC:TermGenie]
synonym: "inhibition of coenzyme F420-dependent nitroimidazole catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of coenzyme F420-dependent nitroimidazole reduction" NARROW [GOC:TermGenie]
synonym: "inhibition of coenzyme F420-dependent nitroreductase activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of coenzyme F420-dependent nitroimidazole breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of coenzyme F420-dependent nitroimidazole catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of coenzyme F420-dependent nitroimidazole reduction" EXACT [GOC:TermGenie]
synonym: "negative regulation of coenzyme F420-dependent nitroreductase activity" RELATED [GOC:TermGenie]
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process
is_a: GO:1900288 ! regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0052799 ! coenzyme F420-dependent bicyclic nitroimidazole catabolic process
relationship: negatively_regulates GO:0052799 ! coenzyme F420-dependent bicyclic nitroimidazole catabolic process
created_by: tt
creation_date: 2012-04-05T06:02:51Z

[Term]
id: GO:1900290
name: positive regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of coenzyme F420-dependent bicyclic nitroimidazole catabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of coenzyme F420-dependent nitroimidazole breakdown" NARROW [GOC:TermGenie]
synonym: "activation of coenzyme F420-dependent nitroimidazole catabolism" NARROW [GOC:TermGenie]
synonym: "activation of coenzyme F420-dependent nitroimidazole reduction" NARROW [GOC:TermGenie]
synonym: "activation of coenzyme F420-dependent nitroreductase activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of coenzyme F420-dependent nitroimidazole breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of coenzyme F420-dependent nitroimidazole catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of coenzyme F420-dependent nitroimidazole reduction" EXACT [GOC:TermGenie]
synonym: "positive regulation of coenzyme F420-dependent nitroreductase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of coenzyme F420-dependent nitroimidazole breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of coenzyme F420-dependent nitroimidazole catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of coenzyme F420-dependent nitroimidazole reduction" EXACT [GOC:TermGenie]
synonym: "up regulation of coenzyme F420-dependent nitroreductase activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of coenzyme F420-dependent nitroimidazole breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of coenzyme F420-dependent nitroimidazole catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of coenzyme F420-dependent nitroimidazole reduction" EXACT [GOC:TermGenie]
synonym: "up-regulation of coenzyme F420-dependent nitroreductase activity" RELATED [GOC:TermGenie]
synonym: "upregulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of coenzyme F420-dependent nitroimidazole breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of coenzyme F420-dependent nitroimidazole catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of coenzyme F420-dependent nitroimidazole reduction" EXACT [GOC:TermGenie]
synonym: "upregulation of coenzyme F420-dependent nitroreductase activity" RELATED [GOC:TermGenie]
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process
is_a: GO:1900288 ! regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0052799 ! coenzyme F420-dependent bicyclic nitroimidazole catabolic process
relationship: positively_regulates GO:0052799 ! coenzyme F420-dependent bicyclic nitroimidazole catabolic process
created_by: tt
creation_date: 2012-04-05T06:02:59Z

[Term]
id: GO:1900291
name: regulation of galactotriose transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of galactotriose transport." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:2001093 ! galactotriose transport
relationship: regulates GO:2001093 ! galactotriose transport
created_by: tt
creation_date: 2012-04-05T07:25:58Z

[Term]
id: GO:1900292
name: negative regulation of galactotriose transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of galactotriose transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of galactotriose transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of galactotriose transport" EXACT [GOC:TermGenie]
synonym: "downregulation of galactotriose transport" EXACT [GOC:TermGenie]
synonym: "inhibition of galactotriose transport" NARROW [GOC:TermGenie]
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:1900291 ! regulation of galactotriose transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:2001093 ! galactotriose transport
relationship: negatively_regulates GO:2001093 ! galactotriose transport
created_by: tt
creation_date: 2012-04-05T07:26:08Z

[Term]
id: GO:1900293
name: positive regulation of galactotriose transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of galactotriose transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of galactotriose transport" NARROW [GOC:TermGenie]
synonym: "up regulation of galactotriose transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of galactotriose transport" EXACT [GOC:TermGenie]
synonym: "upregulation of galactotriose transport" EXACT [GOC:TermGenie]
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:1900291 ! regulation of galactotriose transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:2001093 ! galactotriose transport
relationship: positively_regulates GO:2001093 ! galactotriose transport
created_by: tt
creation_date: 2012-04-05T07:26:28Z

[Term]
id: GO:1900294
name: regulation of heptasaccharide transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of heptasaccharide transport." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:2001104 ! heptasaccharide transport
relationship: regulates GO:2001104 ! heptasaccharide transport
created_by: tt
creation_date: 2012-04-05T07:40:40Z

[Term]
id: GO:1900295
name: negative regulation of heptasaccharide transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of heptasaccharide transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of heptasaccharide transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of heptasaccharide transport" EXACT [GOC:TermGenie]
synonym: "downregulation of heptasaccharide transport" EXACT [GOC:TermGenie]
synonym: "inhibition of heptasaccharide transport" NARROW [GOC:TermGenie]
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:1900294 ! regulation of heptasaccharide transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:2001104 ! heptasaccharide transport
relationship: negatively_regulates GO:2001104 ! heptasaccharide transport
created_by: tt
creation_date: 2012-04-05T07:40:49Z

[Term]
id: GO:1900296
name: positive regulation of heptasaccharide transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of heptasaccharide transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of heptasaccharide transport" NARROW [GOC:TermGenie]
synonym: "up regulation of heptasaccharide transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of heptasaccharide transport" EXACT [GOC:TermGenie]
synonym: "upregulation of heptasaccharide transport" EXACT [GOC:TermGenie]
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:1900294 ! regulation of heptasaccharide transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:2001104 ! heptasaccharide transport
relationship: positively_regulates GO:2001104 ! heptasaccharide transport
created_by: tt
creation_date: 2012-04-05T07:40:58Z

[Term]
id: GO:1900297
name: regulation of hexasaccharide transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hexasaccharide transport." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:2001102 ! hexasaccharide transport
relationship: regulates GO:2001102 ! hexasaccharide transport
created_by: tt
creation_date: 2012-04-05T07:44:31Z

[Term]
id: GO:1900298
name: negative regulation of hexasaccharide transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hexasaccharide transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of hexasaccharide transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of hexasaccharide transport" EXACT [GOC:TermGenie]
synonym: "downregulation of hexasaccharide transport" EXACT [GOC:TermGenie]
synonym: "inhibition of hexasaccharide transport" NARROW [GOC:TermGenie]
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:1900297 ! regulation of hexasaccharide transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:2001102 ! hexasaccharide transport
relationship: negatively_regulates GO:2001102 ! hexasaccharide transport
created_by: tt
creation_date: 2012-04-05T07:44:40Z

[Term]
id: GO:1900299
name: positive regulation of hexasaccharide transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hexasaccharide transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of hexasaccharide transport" NARROW [GOC:TermGenie]
synonym: "up regulation of hexasaccharide transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of hexasaccharide transport" EXACT [GOC:TermGenie]
synonym: "upregulation of hexasaccharide transport" EXACT [GOC:TermGenie]
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:1900297 ! regulation of hexasaccharide transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:2001102 ! hexasaccharide transport
relationship: positively_regulates GO:2001102 ! hexasaccharide transport
created_by: tt
creation_date: 2012-04-05T07:44:49Z

[Term]
id: GO:1900300
name: regulation of laminarabiose transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of laminarabiose transport." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:2001086 ! laminarabiose transport
relationship: regulates GO:2001086 ! laminarabiose transport
created_by: tt
creation_date: 2012-04-05T07:57:19Z

[Term]
id: GO:1900301
name: negative regulation of laminarabiose transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of laminarabiose transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of laminarabiose transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of laminarabiose transport" EXACT [GOC:TermGenie]
synonym: "downregulation of laminarabiose transport" EXACT [GOC:TermGenie]
synonym: "inhibition of laminarabiose transport" NARROW [GOC:TermGenie]
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:1900300 ! regulation of laminarabiose transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:2001086 ! laminarabiose transport
relationship: negatively_regulates GO:2001086 ! laminarabiose transport
created_by: tt
creation_date: 2012-04-05T07:57:28Z

[Term]
id: GO:1900302
name: positive regulation of laminarabiose transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of laminarabiose transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of laminarabiose transport" NARROW [GOC:TermGenie]
synonym: "up regulation of laminarabiose transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of laminarabiose transport" EXACT [GOC:TermGenie]
synonym: "upregulation of laminarabiose transport" EXACT [GOC:TermGenie]
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:1900300 ! regulation of laminarabiose transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:2001086 ! laminarabiose transport
relationship: positively_regulates GO:2001086 ! laminarabiose transport
created_by: tt
creation_date: 2012-04-05T07:57:37Z

[Term]
id: GO:1900303
name: regulation of laminaritriose transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of laminaritriose transport." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:2001097 ! laminaritriose transport
relationship: regulates GO:2001097 ! laminaritriose transport
created_by: tt
creation_date: 2012-04-05T07:57:49Z

[Term]
id: GO:1900304
name: negative regulation of laminaritriose transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of laminaritriose transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of laminaritriose transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of laminaritriose transport" EXACT [GOC:TermGenie]
synonym: "downregulation of laminaritriose transport" EXACT [GOC:TermGenie]
synonym: "inhibition of laminaritriose transport" NARROW [GOC:TermGenie]
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:1900303 ! regulation of laminaritriose transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:2001097 ! laminaritriose transport
relationship: negatively_regulates GO:2001097 ! laminaritriose transport
created_by: tt
creation_date: 2012-04-05T07:57:58Z

[Term]
id: GO:1900305
name: positive regulation of laminaritriose transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of laminaritriose transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of laminaritriose transport" NARROW [GOC:TermGenie]
synonym: "up regulation of laminaritriose transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of laminaritriose transport" EXACT [GOC:TermGenie]
synonym: "upregulation of laminaritriose transport" EXACT [GOC:TermGenie]
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:1900303 ! regulation of laminaritriose transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:2001097 ! laminaritriose transport
relationship: positively_regulates GO:2001097 ! laminaritriose transport
created_by: tt
creation_date: 2012-04-05T07:58:06Z

[Term]
id: GO:1900306
name: regulation of maltoheptaose transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of maltoheptaose transport." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:1900294 ! regulation of heptasaccharide transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:2001105 ! maltoheptaose transport
relationship: regulates GO:2001105 ! maltoheptaose transport
created_by: tt
creation_date: 2012-04-05T07:58:18Z

[Term]
id: GO:1900307
name: negative regulation of maltoheptaose transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of maltoheptaose transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of maltoheptaose transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of maltoheptaose transport" EXACT [GOC:TermGenie]
synonym: "downregulation of maltoheptaose transport" EXACT [GOC:TermGenie]
synonym: "inhibition of maltoheptaose transport" NARROW [GOC:TermGenie]
is_a: GO:1900295 ! negative regulation of heptasaccharide transport
is_a: GO:1900306 ! regulation of maltoheptaose transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:2001105 ! maltoheptaose transport
relationship: negatively_regulates GO:2001105 ! maltoheptaose transport
created_by: tt
creation_date: 2012-04-05T07:58:27Z

[Term]
id: GO:1900308
name: positive regulation of maltoheptaose transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of maltoheptaose transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of maltoheptaose transport" NARROW [GOC:TermGenie]
synonym: "up regulation of maltoheptaose transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of maltoheptaose transport" EXACT [GOC:TermGenie]
synonym: "upregulation of maltoheptaose transport" EXACT [GOC:TermGenie]
is_a: GO:1900296 ! positive regulation of heptasaccharide transport
is_a: GO:1900306 ! regulation of maltoheptaose transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:2001105 ! maltoheptaose transport
relationship: positively_regulates GO:2001105 ! maltoheptaose transport
created_by: tt
creation_date: 2012-04-05T07:58:35Z

[Term]
id: GO:1900309
name: regulation of maltoheptaose metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of maltoheptaose metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of maltoheptaose metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006109 ! regulation of carbohydrate metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:2001122 ! maltoheptaose metabolic process
relationship: regulates GO:2001122 ! maltoheptaose metabolic process
created_by: tt
creation_date: 2012-04-05T07:58:48Z

[Term]
id: GO:1900310
name: negative regulation of maltoheptaose metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of maltoheptaose metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of maltoheptaose metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of maltoheptaose metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of maltoheptaose metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of maltoheptaose metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of maltoheptaose metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of maltoheptaose metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of maltoheptaose metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of maltoheptaose metabolism" NARROW [GOC:TermGenie]
synonym: "negative regulation of maltoheptaose metabolism" EXACT [GOC:TermGenie]
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:1900309 ! regulation of maltoheptaose metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:2001122 ! maltoheptaose metabolic process
relationship: negatively_regulates GO:2001122 ! maltoheptaose metabolic process
created_by: tt
creation_date: 2012-04-05T07:58:58Z

[Term]
id: GO:1900311
name: positive regulation of maltoheptaose metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of maltoheptaose metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of maltoheptaose metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of maltoheptaose metabolism" NARROW [GOC:TermGenie]
synonym: "positive regulation of maltoheptaose metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of maltoheptaose metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of maltoheptaose metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of maltoheptaose metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of maltoheptaose metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of maltoheptaose metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of maltoheptaose metabolism" EXACT [GOC:TermGenie]
is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process
is_a: GO:1900309 ! regulation of maltoheptaose metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:2001122 ! maltoheptaose metabolic process
relationship: positively_regulates GO:2001122 ! maltoheptaose metabolic process
created_by: tt
creation_date: 2012-04-05T07:59:06Z

[Term]
id: GO:1900312
name: regulation of maltohexaose transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of maltohexaose transport." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:1900297 ! regulation of hexasaccharide transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:2001103 ! maltohexaose transport
relationship: regulates GO:2001103 ! maltohexaose transport
created_by: tt
creation_date: 2012-04-05T07:59:18Z

[Term]
id: GO:1900313
name: negative regulation of maltohexaose transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of maltohexaose transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of maltohexaose transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of maltohexaose transport" EXACT [GOC:TermGenie]
synonym: "downregulation of maltohexaose transport" EXACT [GOC:TermGenie]
synonym: "inhibition of maltohexaose transport" NARROW [GOC:TermGenie]
is_a: GO:1900298 ! negative regulation of hexasaccharide transport
is_a: GO:1900312 ! regulation of maltohexaose transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:2001103 ! maltohexaose transport
relationship: negatively_regulates GO:2001103 ! maltohexaose transport
created_by: tt
creation_date: 2012-04-05T07:59:26Z

[Term]
id: GO:1900314
name: positive regulation of maltohexaose transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of maltohexaose transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of maltohexaose transport" NARROW [GOC:TermGenie]
synonym: "up regulation of maltohexaose transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of maltohexaose transport" EXACT [GOC:TermGenie]
synonym: "upregulation of maltohexaose transport" EXACT [GOC:TermGenie]
is_a: GO:1900299 ! positive regulation of hexasaccharide transport
is_a: GO:1900312 ! regulation of maltohexaose transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:2001103 ! maltohexaose transport
relationship: positively_regulates GO:2001103 ! maltohexaose transport
created_by: tt
creation_date: 2012-04-05T07:59:35Z

[Term]
id: GO:1900315
name: regulation of maltopentaose transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of maltopentaose transport." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:1900360 ! regulation of pentasaccharide transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:2001101 ! maltopentaose transport
relationship: regulates GO:2001101 ! maltopentaose transport
created_by: tt
creation_date: 2012-04-05T07:59:47Z

[Term]
id: GO:1900316
name: negative regulation of maltopentaose transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of maltopentaose transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of maltopentaose transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of maltopentaose transport" EXACT [GOC:TermGenie]
synonym: "downregulation of maltopentaose transport" EXACT [GOC:TermGenie]
synonym: "inhibition of maltopentaose transport" NARROW [GOC:TermGenie]
is_a: GO:1900315 ! regulation of maltopentaose transport
is_a: GO:1900361 ! negative regulation of pentasaccharide transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:2001101 ! maltopentaose transport
relationship: negatively_regulates GO:2001101 ! maltopentaose transport
created_by: tt
creation_date: 2012-04-05T07:59:56Z

[Term]
id: GO:1900317
name: positive regulation of maltopentaose transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of maltopentaose transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of maltopentaose transport" NARROW [GOC:TermGenie]
synonym: "up regulation of maltopentaose transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of maltopentaose transport" EXACT [GOC:TermGenie]
synonym: "upregulation of maltopentaose transport" EXACT [GOC:TermGenie]
is_a: GO:1900315 ! regulation of maltopentaose transport
is_a: GO:1900362 ! positive regulation of pentasaccharide transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:2001101 ! maltopentaose transport
relationship: positively_regulates GO:2001101 ! maltopentaose transport
created_by: tt
creation_date: 2012-04-05T08:00:04Z

[Term]
id: GO:1900318
name: regulation of methane biosynthetic process from dimethylamine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of methane biosynthetic process from dimethylamine." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0043457 ! regulation of cellular respiration
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
is_a: GO:1901577 ! regulation of alkane biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:2001129 ! methane biosynthetic process from dimethylamine
relationship: regulates GO:2001129 ! methane biosynthetic process from dimethylamine
created_by: tt
creation_date: 2012-04-06T01:43:21Z

[Term]
id: GO:1900319
name: negative regulation of methane biosynthetic process from dimethylamine
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from dimethylamine." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of methane biosynthetic process from dimethylamine" EXACT [GOC:TermGenie]
synonym: "down-regulation of methane biosynthetic process from dimethylamine" EXACT [GOC:TermGenie]
synonym: "downregulation of methane biosynthetic process from dimethylamine" EXACT [GOC:TermGenie]
synonym: "inhibition of methane biosynthetic process from dimethylamine" NARROW [GOC:TermGenie]
is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process
is_a: GO:1900318 ! regulation of methane biosynthetic process from dimethylamine
is_a: GO:1901578 ! negative regulation of alkane biosynthetic process
is_a: GO:1901856 ! negative regulation of cellular respiration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:2001129 ! methane biosynthetic process from dimethylamine
relationship: negatively_regulates GO:2001129 ! methane biosynthetic process from dimethylamine
created_by: tt
creation_date: 2012-04-06T01:43:31Z

[Term]
id: GO:1900320
name: positive regulation of methane biosynthetic process from dimethylamine
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from dimethylamine." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of methane biosynthetic process from dimethylamine" NARROW [GOC:TermGenie]
synonym: "up regulation of methane biosynthetic process from dimethylamine" EXACT [GOC:TermGenie]
synonym: "up-regulation of methane biosynthetic process from dimethylamine" EXACT [GOC:TermGenie]
synonym: "upregulation of methane biosynthetic process from dimethylamine" EXACT [GOC:TermGenie]
is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process
is_a: GO:1900318 ! regulation of methane biosynthetic process from dimethylamine
is_a: GO:1901579 ! positive regulation of alkane biosynthetic process
is_a: GO:1901857 ! positive regulation of cellular respiration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:2001129 ! methane biosynthetic process from dimethylamine
relationship: positively_regulates GO:2001129 ! methane biosynthetic process from dimethylamine
created_by: tt
creation_date: 2012-04-06T01:43:40Z

[Term]
id: GO:1900321
name: regulation of maltotetraose transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of maltotetraose transport." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:2001099 ! maltotetraose transport
relationship: regulates GO:2001099 ! maltotetraose transport
created_by: tt
creation_date: 2012-04-06T01:45:36Z

[Term]
id: GO:1900322
name: negative regulation of maltotetraose transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of maltotetraose transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of maltotetraose transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of maltotetraose transport" EXACT [GOC:TermGenie]
synonym: "downregulation of maltotetraose transport" EXACT [GOC:TermGenie]
synonym: "inhibition of maltotetraose transport" NARROW [GOC:TermGenie]
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:1900321 ! regulation of maltotetraose transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:2001099 ! maltotetraose transport
relationship: negatively_regulates GO:2001099 ! maltotetraose transport
created_by: tt
creation_date: 2012-04-06T01:45:45Z

[Term]
id: GO:1900323
name: positive regulation of maltotetraose transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of maltotetraose transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of maltotetraose transport" NARROW [GOC:TermGenie]
synonym: "up regulation of maltotetraose transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of maltotetraose transport" EXACT [GOC:TermGenie]
synonym: "upregulation of maltotetraose transport" EXACT [GOC:TermGenie]
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:1900321 ! regulation of maltotetraose transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:2001099 ! maltotetraose transport
relationship: positively_regulates GO:2001099 ! maltotetraose transport
created_by: tt
creation_date: 2012-04-06T01:45:54Z

[Term]
id: GO:1900324
name: regulation of maltotriulose transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of maltotriulose transport." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:2001090 ! maltotriulose transport
relationship: regulates GO:2001090 ! maltotriulose transport
created_by: tt
creation_date: 2012-04-06T01:48:06Z

[Term]
id: GO:1900325
name: negative regulation of maltotriulose transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of maltotriulose transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of maltotriulose transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of maltotriulose transport" EXACT [GOC:TermGenie]
synonym: "downregulation of maltotriulose transport" EXACT [GOC:TermGenie]
synonym: "inhibition of maltotriulose transport" NARROW [GOC:TermGenie]
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:1900324 ! regulation of maltotriulose transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:2001090 ! maltotriulose transport
relationship: negatively_regulates GO:2001090 ! maltotriulose transport
created_by: tt
creation_date: 2012-04-06T01:48:16Z

[Term]
id: GO:1900326
name: positive regulation of maltotriulose transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of maltotriulose transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of maltotriulose transport" NARROW [GOC:TermGenie]
synonym: "up regulation of maltotriulose transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of maltotriulose transport" EXACT [GOC:TermGenie]
synonym: "upregulation of maltotriulose transport" EXACT [GOC:TermGenie]
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:1900324 ! regulation of maltotriulose transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:2001090 ! maltotriulose transport
relationship: positively_regulates GO:2001090 ! maltotriulose transport
created_by: tt
creation_date: 2012-04-06T01:48:25Z

[Term]
id: GO:1900327
name: regulation of mannotriose transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mannotriose transport." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:2001095 ! mannotriose transport
relationship: regulates GO:2001095 ! mannotriose transport
created_by: tt
creation_date: 2012-04-06T01:50:05Z

[Term]
id: GO:1900328
name: negative regulation of mannotriose transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mannotriose transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of mannotriose transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of mannotriose transport" EXACT [GOC:TermGenie]
synonym: "downregulation of mannotriose transport" EXACT [GOC:TermGenie]
synonym: "inhibition of mannotriose transport" NARROW [GOC:TermGenie]
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:1900327 ! regulation of mannotriose transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:2001095 ! mannotriose transport
relationship: negatively_regulates GO:2001095 ! mannotriose transport
created_by: tt
creation_date: 2012-04-06T01:50:13Z

[Term]
id: GO:1900329
name: positive regulation of mannotriose transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mannotriose transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of mannotriose transport" NARROW [GOC:TermGenie]
synonym: "up regulation of mannotriose transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of mannotriose transport" EXACT [GOC:TermGenie]
synonym: "upregulation of mannotriose transport" EXACT [GOC:TermGenie]
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:1900327 ! regulation of mannotriose transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:2001095 ! mannotriose transport
relationship: positively_regulates GO:2001095 ! mannotriose transport
created_by: tt
creation_date: 2012-04-06T01:50:22Z

[Term]
id: GO:1900330
name: regulation of methane biosynthetic process from trimethylamine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of methane biosynthetic process from trimethylamine." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0043457 ! regulation of cellular respiration
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
is_a: GO:1901577 ! regulation of alkane biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:2001130 ! methane biosynthetic process from trimethylamine
relationship: regulates GO:2001130 ! methane biosynthetic process from trimethylamine
created_by: tt
creation_date: 2012-04-06T01:53:03Z

[Term]
id: GO:1900331
name: negative regulation of methane biosynthetic process from trimethylamine
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from trimethylamine." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of methane biosynthetic process from trimethylamine" EXACT [GOC:TermGenie]
synonym: "down-regulation of methane biosynthetic process from trimethylamine" EXACT [GOC:TermGenie]
synonym: "downregulation of methane biosynthetic process from trimethylamine" EXACT [GOC:TermGenie]
synonym: "inhibition of methane biosynthetic process from trimethylamine" NARROW [GOC:TermGenie]
is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process
is_a: GO:1900330 ! regulation of methane biosynthetic process from trimethylamine
is_a: GO:1901578 ! negative regulation of alkane biosynthetic process
is_a: GO:1901856 ! negative regulation of cellular respiration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:2001130 ! methane biosynthetic process from trimethylamine
relationship: negatively_regulates GO:2001130 ! methane biosynthetic process from trimethylamine
created_by: tt
creation_date: 2012-04-06T01:53:12Z

[Term]
id: GO:1900332
name: positive regulation of methane biosynthetic process from trimethylamine
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from trimethylamine." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of methane biosynthetic process from trimethylamine" NARROW [GOC:TermGenie]
synonym: "up regulation of methane biosynthetic process from trimethylamine" EXACT [GOC:TermGenie]
synonym: "up-regulation of methane biosynthetic process from trimethylamine" EXACT [GOC:TermGenie]
synonym: "upregulation of methane biosynthetic process from trimethylamine" EXACT [GOC:TermGenie]
is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process
is_a: GO:1900330 ! regulation of methane biosynthetic process from trimethylamine
is_a: GO:1901579 ! positive regulation of alkane biosynthetic process
is_a: GO:1901857 ! positive regulation of cellular respiration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:2001130 ! methane biosynthetic process from trimethylamine
relationship: positively_regulates GO:2001130 ! methane biosynthetic process from trimethylamine
created_by: tt
creation_date: 2012-04-06T01:53:20Z

[Term]
id: GO:1900333
name: regulation of methane biosynthetic process from 3-(methylthio)propionic acid
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of methane biosynthetic process from 3-(methylthio)propionic acid." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0019217 ! regulation of fatty acid metabolic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
is_a: GO:0043457 ! regulation of cellular respiration
is_a: GO:1901577 ! regulation of alkane biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:2001132 ! methane biosynthetic process from 3-(methylthio)propionic acid
relationship: regulates GO:2001132 ! methane biosynthetic process from 3-(methylthio)propionic acid
created_by: tt
creation_date: 2012-04-06T01:56:13Z

[Term]
id: GO:1900334
name: negative regulation of methane biosynthetic process from 3-(methylthio)propionic acid
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from 3-(methylthio)propionic acid." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of methane biosynthetic process from 3-(methylthio)propionic acid" EXACT [GOC:TermGenie]
synonym: "down-regulation of methane biosynthetic process from 3-(methylthio)propionic acid" EXACT [GOC:TermGenie]
synonym: "downregulation of methane biosynthetic process from 3-(methylthio)propionic acid" EXACT [GOC:TermGenie]
synonym: "inhibition of methane biosynthetic process from 3-(methylthio)propionic acid" NARROW [GOC:TermGenie]
is_a: GO:0045922 ! negative regulation of fatty acid metabolic process
is_a: GO:0051175 ! negative regulation of sulfur metabolic process
is_a: GO:1900333 ! regulation of methane biosynthetic process from 3-(methylthio)propionic acid
is_a: GO:1901578 ! negative regulation of alkane biosynthetic process
is_a: GO:1901856 ! negative regulation of cellular respiration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:2001132 ! methane biosynthetic process from 3-(methylthio)propionic acid
relationship: negatively_regulates GO:2001132 ! methane biosynthetic process from 3-(methylthio)propionic acid
created_by: tt
creation_date: 2012-04-06T01:56:23Z

[Term]
id: GO:1900335
name: positive regulation of methane biosynthetic process from 3-(methylthio)propionic acid
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from 3-(methylthio)propionic acid." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of methane biosynthetic process from 3-(methylthio)propionic acid" NARROW [GOC:TermGenie]
synonym: "up regulation of methane biosynthetic process from 3-(methylthio)propionic acid" EXACT [GOC:TermGenie]
synonym: "up-regulation of methane biosynthetic process from 3-(methylthio)propionic acid" EXACT [GOC:TermGenie]
synonym: "upregulation of methane biosynthetic process from 3-(methylthio)propionic acid" EXACT [GOC:TermGenie]
is_a: GO:0045923 ! positive regulation of fatty acid metabolic process
is_a: GO:0051176 ! positive regulation of sulfur metabolic process
is_a: GO:1900333 ! regulation of methane biosynthetic process from 3-(methylthio)propionic acid
is_a: GO:1901579 ! positive regulation of alkane biosynthetic process
is_a: GO:1901857 ! positive regulation of cellular respiration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:2001132 ! methane biosynthetic process from 3-(methylthio)propionic acid
relationship: positively_regulates GO:2001132 ! methane biosynthetic process from 3-(methylthio)propionic acid
created_by: tt
creation_date: 2012-04-06T01:56:31Z

[Term]
id: GO:1900336
name: regulation of methane biosynthetic process from carbon monoxide
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of methane biosynthetic process from carbon monoxide." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0043457 ! regulation of cellular respiration
is_a: GO:1901577 ! regulation of alkane biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:2001134 ! methane biosynthetic process from carbon monoxide
relationship: regulates GO:2001134 ! methane biosynthetic process from carbon monoxide
created_by: tt
creation_date: 2012-04-06T02:03:15Z

[Term]
id: GO:1900337
name: negative regulation of methane biosynthetic process from carbon monoxide
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from carbon monoxide." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of methane biosynthetic process from carbon monoxide" EXACT [GOC:TermGenie]
synonym: "down-regulation of methane biosynthetic process from carbon monoxide" EXACT [GOC:TermGenie]
synonym: "downregulation of methane biosynthetic process from carbon monoxide" EXACT [GOC:TermGenie]
synonym: "inhibition of methane biosynthetic process from carbon monoxide" NARROW [GOC:TermGenie]
is_a: GO:1900336 ! regulation of methane biosynthetic process from carbon monoxide
is_a: GO:1901578 ! negative regulation of alkane biosynthetic process
is_a: GO:1901856 ! negative regulation of cellular respiration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:2001134 ! methane biosynthetic process from carbon monoxide
relationship: negatively_regulates GO:2001134 ! methane biosynthetic process from carbon monoxide
created_by: tt
creation_date: 2012-04-06T02:03:24Z

[Term]
id: GO:1900338
name: positive regulation of methane biosynthetic process from carbon monoxide
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from carbon monoxide." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of methane biosynthetic process from carbon monoxide" NARROW [GOC:TermGenie]
synonym: "up regulation of methane biosynthetic process from carbon monoxide" EXACT [GOC:TermGenie]
synonym: "up-regulation of methane biosynthetic process from carbon monoxide" EXACT [GOC:TermGenie]
synonym: "upregulation of methane biosynthetic process from carbon monoxide" EXACT [GOC:TermGenie]
is_a: GO:1900336 ! regulation of methane biosynthetic process from carbon monoxide
is_a: GO:1901579 ! positive regulation of alkane biosynthetic process
is_a: GO:1901857 ! positive regulation of cellular respiration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:2001134 ! methane biosynthetic process from carbon monoxide
relationship: positively_regulates GO:2001134 ! methane biosynthetic process from carbon monoxide
created_by: tt
creation_date: 2012-04-06T02:03:33Z

[Term]
id: GO:1900339
name: regulation of methane biosynthetic process from formic acid
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of methane biosynthetic process from formic acid." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0010565 ! regulation of cellular ketone metabolic process
is_a: GO:0043457 ! regulation of cellular respiration
is_a: GO:1901577 ! regulation of alkane biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:2001127 ! methane biosynthetic process from formic acid
relationship: regulates GO:2001127 ! methane biosynthetic process from formic acid
created_by: tt
creation_date: 2012-04-06T02:04:53Z

[Term]
id: GO:1900340
name: negative regulation of methane biosynthetic process from formic acid
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from formic acid." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of methane biosynthetic process from formic acid" EXACT [GOC:TermGenie]
synonym: "down-regulation of methane biosynthetic process from formic acid" EXACT [GOC:TermGenie]
synonym: "downregulation of methane biosynthetic process from formic acid" EXACT [GOC:TermGenie]
synonym: "inhibition of methane biosynthetic process from formic acid" NARROW [GOC:TermGenie]
is_a: GO:1900339 ! regulation of methane biosynthetic process from formic acid
is_a: GO:1901578 ! negative regulation of alkane biosynthetic process
is_a: GO:1901856 ! negative regulation of cellular respiration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:2001127 ! methane biosynthetic process from formic acid
relationship: negatively_regulates GO:2001127 ! methane biosynthetic process from formic acid
created_by: tt
creation_date: 2012-04-06T02:05:03Z

[Term]
id: GO:1900341
name: positive regulation of methane biosynthetic process from formic acid
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from formic acid." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of methane biosynthetic process from formic acid" NARROW [GOC:TermGenie]
synonym: "up regulation of methane biosynthetic process from formic acid" EXACT [GOC:TermGenie]
synonym: "up-regulation of methane biosynthetic process from formic acid" EXACT [GOC:TermGenie]
synonym: "upregulation of methane biosynthetic process from formic acid" EXACT [GOC:TermGenie]
is_a: GO:1900339 ! regulation of methane biosynthetic process from formic acid
is_a: GO:1901579 ! positive regulation of alkane biosynthetic process
is_a: GO:1901857 ! positive regulation of cellular respiration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:2001127 ! methane biosynthetic process from formic acid
relationship: positively_regulates GO:2001127 ! methane biosynthetic process from formic acid
created_by: tt
creation_date: 2012-04-06T02:05:11Z

[Term]
id: GO:1900342
name: regulation of methane biosynthetic process from dimethyl sulfide
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of methane biosynthetic process from dimethyl sulfide." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0042762 ! regulation of sulfur metabolic process
is_a: GO:0043457 ! regulation of cellular respiration
is_a: GO:1901577 ! regulation of alkane biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:2001131 ! methane biosynthetic process from dimethyl sulfide
relationship: regulates GO:2001131 ! methane biosynthetic process from dimethyl sulfide
created_by: tt
creation_date: 2012-04-06T02:06:38Z

[Term]
id: GO:1900343
name: negative regulation of methane biosynthetic process from dimethyl sulfide
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from dimethyl sulfide." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of methane biosynthetic process from dimethyl sulfide" EXACT [GOC:TermGenie]
synonym: "down-regulation of methane biosynthetic process from dimethyl sulfide" EXACT [GOC:TermGenie]
synonym: "downregulation of methane biosynthetic process from dimethyl sulfide" EXACT [GOC:TermGenie]
synonym: "inhibition of methane biosynthetic process from dimethyl sulfide" NARROW [GOC:TermGenie]
is_a: GO:0051175 ! negative regulation of sulfur metabolic process
is_a: GO:1900342 ! regulation of methane biosynthetic process from dimethyl sulfide
is_a: GO:1901578 ! negative regulation of alkane biosynthetic process
is_a: GO:1901856 ! negative regulation of cellular respiration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:2001131 ! methane biosynthetic process from dimethyl sulfide
relationship: negatively_regulates GO:2001131 ! methane biosynthetic process from dimethyl sulfide
created_by: tt
creation_date: 2012-04-06T02:06:47Z

[Term]
id: GO:1900344
name: positive regulation of methane biosynthetic process from dimethyl sulfide
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from dimethyl sulfide." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of methane biosynthetic process from dimethyl sulfide" NARROW [GOC:TermGenie]
synonym: "up regulation of methane biosynthetic process from dimethyl sulfide" EXACT [GOC:TermGenie]
synonym: "up-regulation of methane biosynthetic process from dimethyl sulfide" EXACT [GOC:TermGenie]
synonym: "upregulation of methane biosynthetic process from dimethyl sulfide" EXACT [GOC:TermGenie]
is_a: GO:0051176 ! positive regulation of sulfur metabolic process
is_a: GO:1900342 ! regulation of methane biosynthetic process from dimethyl sulfide
is_a: GO:1901579 ! positive regulation of alkane biosynthetic process
is_a: GO:1901857 ! positive regulation of cellular respiration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:2001131 ! methane biosynthetic process from dimethyl sulfide
relationship: positively_regulates GO:2001131 ! methane biosynthetic process from dimethyl sulfide
created_by: tt
creation_date: 2012-04-06T02:06:56Z

[Term]
id: GO:1900345
name: regulation of methane biosynthetic process from methanethiol
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of methane biosynthetic process from methanethiol." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0042762 ! regulation of sulfur metabolic process
is_a: GO:0043457 ! regulation of cellular respiration
is_a: GO:1901577 ! regulation of alkane biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:2001133 ! methane biosynthetic process from methanethiol
relationship: regulates GO:2001133 ! methane biosynthetic process from methanethiol
created_by: tt
creation_date: 2012-04-06T02:09:49Z

[Term]
id: GO:1900346
name: negative regulation of methane biosynthetic process from methanethiol
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from methanethiol." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of methane biosynthetic process from methanethiol" EXACT [GOC:TermGenie]
synonym: "down-regulation of methane biosynthetic process from methanethiol" EXACT [GOC:TermGenie]
synonym: "downregulation of methane biosynthetic process from methanethiol" EXACT [GOC:TermGenie]
synonym: "inhibition of methane biosynthetic process from methanethiol" NARROW [GOC:TermGenie]
is_a: GO:0051175 ! negative regulation of sulfur metabolic process
is_a: GO:1900345 ! regulation of methane biosynthetic process from methanethiol
is_a: GO:1901578 ! negative regulation of alkane biosynthetic process
is_a: GO:1901856 ! negative regulation of cellular respiration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:2001133 ! methane biosynthetic process from methanethiol
relationship: negatively_regulates GO:2001133 ! methane biosynthetic process from methanethiol
created_by: tt
creation_date: 2012-04-06T02:09:58Z

[Term]
id: GO:1900347
name: positive regulation of methane biosynthetic process from methanethiol
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from methanethiol." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of methane biosynthetic process from methanethiol" NARROW [GOC:TermGenie]
synonym: "up regulation of methane biosynthetic process from methanethiol" EXACT [GOC:TermGenie]
synonym: "up-regulation of methane biosynthetic process from methanethiol" EXACT [GOC:TermGenie]
synonym: "upregulation of methane biosynthetic process from methanethiol" EXACT [GOC:TermGenie]
is_a: GO:0051176 ! positive regulation of sulfur metabolic process
is_a: GO:1900345 ! regulation of methane biosynthetic process from methanethiol
is_a: GO:1901579 ! positive regulation of alkane biosynthetic process
is_a: GO:1901857 ! positive regulation of cellular respiration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:2001133 ! methane biosynthetic process from methanethiol
relationship: positively_regulates GO:2001133 ! methane biosynthetic process from methanethiol
created_by: tt
creation_date: 2012-04-06T02:10:06Z

[Term]
id: GO:1900348
name: regulation of methane biosynthetic process from methylamine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of methane biosynthetic process from methylamine." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0043457 ! regulation of cellular respiration
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
is_a: GO:1901577 ! regulation of alkane biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:2001128 ! methane biosynthetic process from methylamine
relationship: regulates GO:2001128 ! methane biosynthetic process from methylamine
created_by: tt
creation_date: 2012-04-06T02:11:54Z

[Term]
id: GO:1900349
name: negative regulation of methane biosynthetic process from methylamine
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from methylamine." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of methane biosynthetic process from methylamine" EXACT [GOC:TermGenie]
synonym: "down-regulation of methane biosynthetic process from methylamine" EXACT [GOC:TermGenie]
synonym: "downregulation of methane biosynthetic process from methylamine" EXACT [GOC:TermGenie]
synonym: "inhibition of methane biosynthetic process from methylamine" NARROW [GOC:TermGenie]
is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process
is_a: GO:1900348 ! regulation of methane biosynthetic process from methylamine
is_a: GO:1901578 ! negative regulation of alkane biosynthetic process
is_a: GO:1901856 ! negative regulation of cellular respiration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:2001128 ! methane biosynthetic process from methylamine
relationship: negatively_regulates GO:2001128 ! methane biosynthetic process from methylamine
created_by: tt
creation_date: 2012-04-06T02:12:04Z

[Term]
id: GO:1900350
name: positive regulation of methane biosynthetic process from methylamine
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from methylamine." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of methane biosynthetic process from methylamine" NARROW [GOC:TermGenie]
synonym: "up regulation of methane biosynthetic process from methylamine" EXACT [GOC:TermGenie]
synonym: "up-regulation of methane biosynthetic process from methylamine" EXACT [GOC:TermGenie]
synonym: "upregulation of methane biosynthetic process from methylamine" EXACT [GOC:TermGenie]
is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process
is_a: GO:1900348 ! regulation of methane biosynthetic process from methylamine
is_a: GO:1901579 ! positive regulation of alkane biosynthetic process
is_a: GO:1901857 ! positive regulation of cellular respiration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:2001128 ! methane biosynthetic process from methylamine
relationship: positively_regulates GO:2001128 ! methane biosynthetic process from methylamine
created_by: tt
creation_date: 2012-04-06T02:12:12Z

[Term]
id: GO:1900351
name: regulation of methanofuran biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of methanofuran biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of methanofuran biosynthesis" EXACT [GOC:TermGenie]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0042068 ! regulation of pteridine metabolic process
is_a: GO:1900354 ! regulation of methanofuran metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:2001120 ! methanofuran biosynthetic process
relationship: regulates GO:2001120 ! methanofuran biosynthetic process
created_by: tt
creation_date: 2012-04-06T02:13:51Z

[Term]
id: GO:1900352
name: negative regulation of methanofuran biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of methanofuran biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of methanofuran biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of methanofuran biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of methanofuran biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of methanofuran biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of methanofuran biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of methanofuran biosynthetic process" EXACT [GOC:TermGenie]
synonym: "inhibition of methanofuran biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of methanofuran biosynthetic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of methanofuran biosynthesis" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0045863 ! negative regulation of pteridine metabolic process
is_a: GO:1900351 ! regulation of methanofuran biosynthetic process
is_a: GO:1900355 ! negative regulation of methanofuran metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:2001120 ! methanofuran biosynthetic process
relationship: negatively_regulates GO:2001120 ! methanofuran biosynthetic process
created_by: tt
creation_date: 2012-04-06T02:14:00Z

[Term]
id: GO:1900353
name: positive regulation of methanofuran biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of methanofuran biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of methanofuran biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of methanofuran biosynthetic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of methanofuran biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of methanofuran biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of methanofuran biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of methanofuran biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of methanofuran biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of methanofuran biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of methanofuran biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0045864 ! positive regulation of pteridine metabolic process
is_a: GO:1900351 ! regulation of methanofuran biosynthetic process
is_a: GO:1900356 ! positive regulation of methanofuran metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:2001120 ! methanofuran biosynthetic process
relationship: positively_regulates GO:2001120 ! methanofuran biosynthetic process
created_by: tt
creation_date: 2012-04-06T02:14:09Z

[Term]
id: GO:1900354
name: regulation of methanofuran metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of methanofuran metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of methanofuran metabolism" EXACT [GOC:TermGenie]
is_a: GO:0031323 ! regulation of cellular metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:2001119 ! methanofuran metabolic process
relationship: regulates GO:2001119 ! methanofuran metabolic process
created_by: tt
creation_date: 2012-04-06T02:15:44Z

[Term]
id: GO:1900355
name: negative regulation of methanofuran metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of methanofuran metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of methanofuran metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of methanofuran metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of methanofuran metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of methanofuran metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of methanofuran metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of methanofuran metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of methanofuran metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of methanofuran metabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of methanofuran metabolism" EXACT [GOC:TermGenie]
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:1900354 ! regulation of methanofuran metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:2001119 ! methanofuran metabolic process
relationship: negatively_regulates GO:2001119 ! methanofuran metabolic process
created_by: tt
creation_date: 2012-04-06T02:15:53Z

[Term]
id: GO:1900356
name: positive regulation of methanofuran metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of methanofuran metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of methanofuran metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of methanofuran metabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of methanofuran metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of methanofuran metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of methanofuran metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of methanofuran metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of methanofuran metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of methanofuran metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of methanofuran metabolism" EXACT [GOC:TermGenie]
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:1900354 ! regulation of methanofuran metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:2001119 ! methanofuran metabolic process
relationship: positively_regulates GO:2001119 ! methanofuran metabolic process
created_by: tt
creation_date: 2012-04-06T02:16:01Z

[Term]
id: GO:1900357
name: regulation of nigerotriose transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nigerotriose transport." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:2001091 ! nigerotriose transport
relationship: regulates GO:2001091 ! nigerotriose transport
created_by: tt
creation_date: 2012-04-06T02:18:06Z

[Term]
id: GO:1900358
name: negative regulation of nigerotriose transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of nigerotriose transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of nigerotriose transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of nigerotriose transport" EXACT [GOC:TermGenie]
synonym: "downregulation of nigerotriose transport" EXACT [GOC:TermGenie]
synonym: "inhibition of nigerotriose transport" NARROW [GOC:TermGenie]
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:1900357 ! regulation of nigerotriose transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:2001091 ! nigerotriose transport
relationship: negatively_regulates GO:2001091 ! nigerotriose transport
created_by: tt
creation_date: 2012-04-06T02:18:21Z

[Term]
id: GO:1900359
name: positive regulation of nigerotriose transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of nigerotriose transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of nigerotriose transport" NARROW [GOC:TermGenie]
synonym: "up regulation of nigerotriose transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of nigerotriose transport" EXACT [GOC:TermGenie]
synonym: "upregulation of nigerotriose transport" EXACT [GOC:TermGenie]
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:1900357 ! regulation of nigerotriose transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:2001091 ! nigerotriose transport
relationship: positively_regulates GO:2001091 ! nigerotriose transport
created_by: tt
creation_date: 2012-04-06T02:18:29Z

[Term]
id: GO:1900360
name: regulation of pentasaccharide transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pentasaccharide transport." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:2001100 ! pentasaccharide transport
relationship: regulates GO:2001100 ! pentasaccharide transport
created_by: tt
creation_date: 2012-04-06T02:19:27Z

[Term]
id: GO:1900361
name: negative regulation of pentasaccharide transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of pentasaccharide transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of pentasaccharide transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of pentasaccharide transport" EXACT [GOC:TermGenie]
synonym: "downregulation of pentasaccharide transport" EXACT [GOC:TermGenie]
synonym: "inhibition of pentasaccharide transport" NARROW [GOC:TermGenie]
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:1900360 ! regulation of pentasaccharide transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:2001100 ! pentasaccharide transport
relationship: negatively_regulates GO:2001100 ! pentasaccharide transport
created_by: tt
creation_date: 2012-04-06T02:19:36Z

[Term]
id: GO:1900362
name: positive regulation of pentasaccharide transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pentasaccharide transport." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of pentasaccharide transport" NARROW [GOC:TermGenie]
synonym: "up regulation of pentasaccharide transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of pentasaccharide transport" EXACT [GOC:TermGenie]
synonym: "upregulation of pentasaccharide transport" EXACT [GOC:TermGenie]
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:1900360 ! regulation of pentasaccharide transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:2001100 ! pentasaccharide transport
relationship: positively_regulates GO:2001100 ! pentasaccharide transport
created_by: tt
creation_date: 2012-04-06T02:19:44Z

[Term]
id: GO:1900363
name: regulation of mRNA polyadenylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mRNA polyadenylation." [GOC:se, GOC:TermGenie, PMID:15121841]
synonym: "regulation of cleavage and polyadenylylation specificity factor activity" NARROW [GOC:TermGenie]
synonym: "regulation of mRNA polyadenylylation" EXACT [GOC:TermGenie]
is_a: GO:0031440 ! regulation of mRNA 3'-end processing
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006378 ! mRNA polyadenylation
relationship: regulates GO:0006378 ! mRNA polyadenylation
created_by: pr
creation_date: 2012-04-12T04:36:21Z

[Term]
id: GO:1900364
name: negative regulation of mRNA polyadenylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA polyadenylation." [GOC:se, GOC:TermGenie, PMID:15121841]
synonym: "down regulation of cleavage and polyadenylylation specificity factor activity" NARROW [GOC:TermGenie]
synonym: "down regulation of mRNA polyadenylation" EXACT [GOC:TermGenie]
synonym: "down regulation of mRNA polyadenylylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of cleavage and polyadenylylation specificity factor activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of mRNA polyadenylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of mRNA polyadenylylation" EXACT [GOC:TermGenie]
synonym: "downregulation of cleavage and polyadenylylation specificity factor activity" NARROW [GOC:TermGenie]
synonym: "downregulation of mRNA polyadenylation" EXACT [GOC:TermGenie]
synonym: "downregulation of mRNA polyadenylylation" EXACT [GOC:TermGenie]
synonym: "inhibition of cleavage and polyadenylylation specificity factor activity" NARROW [GOC:TermGenie]
synonym: "inhibition of mRNA polyadenylation" NARROW [GOC:TermGenie]
synonym: "inhibition of mRNA polyadenylylation" NARROW [GOC:TermGenie]
synonym: "negative regulation of cleavage and polyadenylylation specificity factor activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of mRNA polyadenylylation" EXACT [GOC:TermGenie]
is_a: GO:0031441 ! negative regulation of mRNA 3'-end processing
is_a: GO:1900363 ! regulation of mRNA polyadenylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006378 ! mRNA polyadenylation
relationship: negatively_regulates GO:0006378 ! mRNA polyadenylation
created_by: pr
creation_date: 2012-04-12T04:36:31Z

[Term]
id: GO:1900365
name: positive regulation of mRNA polyadenylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mRNA polyadenylation." [GOC:se, GOC:TermGenie, PMID:15121841]
synonym: "activation of cleavage and polyadenylylation specificity factor activity" NARROW [GOC:TermGenie]
synonym: "activation of mRNA polyadenylation" NARROW [GOC:TermGenie]
synonym: "activation of mRNA polyadenylylation" NARROW [GOC:TermGenie]
synonym: "positive regulation of cleavage and polyadenylylation specificity factor activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of mRNA polyadenylylation" EXACT [GOC:TermGenie]
synonym: "up regulation of cleavage and polyadenylylation specificity factor activity" NARROW [GOC:TermGenie]
synonym: "up regulation of mRNA polyadenylation" EXACT [GOC:TermGenie]
synonym: "up regulation of mRNA polyadenylylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of cleavage and polyadenylylation specificity factor activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of mRNA polyadenylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of mRNA polyadenylylation" EXACT [GOC:TermGenie]
synonym: "upregulation of cleavage and polyadenylylation specificity factor activity" NARROW [GOC:TermGenie]
synonym: "upregulation of mRNA polyadenylation" EXACT [GOC:TermGenie]
synonym: "upregulation of mRNA polyadenylylation" EXACT [GOC:TermGenie]
is_a: GO:0031442 ! positive regulation of mRNA 3'-end processing
is_a: GO:1900363 ! regulation of mRNA polyadenylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006378 ! mRNA polyadenylation
relationship: positively_regulates GO:0006378 ! mRNA polyadenylation
created_by: pr
creation_date: 2012-04-12T04:36:39Z

[Term]
id: GO:1900366
name: negative regulation of defense response to insect
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of defense response to insect." [GOC:TermGenie, PMID:22474183]
synonym: "down regulation of defense response to insect" EXACT [GOC:TermGenie]
synonym: "down regulation of physiological defense response to insect" EXACT [GOC:TermGenie]
synonym: "down-regulation of defense response to insect" EXACT [GOC:TermGenie]
synonym: "down-regulation of physiological defense response to insect" EXACT [GOC:TermGenie]
synonym: "downregulation of defense response to insect" EXACT [GOC:TermGenie]
synonym: "downregulation of physiological defense response to insect" EXACT [GOC:TermGenie]
synonym: "inhibition of defense response to insect" NARROW [GOC:TermGenie]
synonym: "inhibition of physiological defense response to insect" NARROW [GOC:TermGenie]
synonym: "negative regulation of physiological defense response to insect" EXACT [GOC:TermGenie]
synonym: "susceptibility to insect" RELATED []
is_a: GO:0002832 ! negative regulation of response to biotic stimulus
is_a: GO:0031348 ! negative regulation of defense response
is_a: GO:0032102 ! negative regulation of response to external stimulus
is_a: GO:0043901 ! negative regulation of multi-organism process
is_a: GO:2000068 ! regulation of defense response to insect
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002213 ! defense response to insect
relationship: negatively_regulates GO:0002213 ! defense response to insect
created_by: dhl
creation_date: 2012-04-12T04:44:00Z

[Term]
id: GO:1900367
name: positive regulation of defense response to insect
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of defense response to insect." [GOC:TermGenie, PMID:22474183]
synonym: "activation of defense response to insect" NARROW [GOC:TermGenie]
synonym: "activation of physiological defense response to insect" NARROW [GOC:TermGenie]
synonym: "positive regulation of physiological defense response to insect" EXACT [GOC:TermGenie]
synonym: "up regulation of defense response to insect" EXACT [GOC:TermGenie]
synonym: "up regulation of physiological defense response to insect" EXACT [GOC:TermGenie]
synonym: "up-regulation of defense response to insect" EXACT [GOC:TermGenie]
synonym: "up-regulation of physiological defense response to insect" EXACT [GOC:TermGenie]
synonym: "upregulation of defense response to insect" EXACT [GOC:TermGenie]
synonym: "upregulation of physiological defense response to insect" EXACT [GOC:TermGenie]
is_a: GO:0002833 ! positive regulation of response to biotic stimulus
is_a: GO:0031349 ! positive regulation of defense response
is_a: GO:0032103 ! positive regulation of response to external stimulus
is_a: GO:0043902 ! positive regulation of multi-organism process
is_a: GO:2000068 ! regulation of defense response to insect
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002213 ! defense response to insect
relationship: positively_regulates GO:0002213 ! defense response to insect
created_by: dhl
creation_date: 2012-04-12T04:44:10Z

[Term]
id: GO:1900368
name: regulation of RNA interference
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of RNA interference." [GOC:kmv, GOC:TermGenie, PMID:22412382]
synonym: "regulation of posttranscriptional gene silencing by siRNA" EXACT [GOC:TermGenie]
synonym: "regulation of RNAi" EXACT [GOC:TermGenie]
is_a: GO:0060147 ! regulation of posttranscriptional gene silencing
is_a: GO:0060966 ! regulation of gene silencing by RNA
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016246 ! RNA interference
relationship: regulates GO:0016246 ! RNA interference
created_by: kmv
creation_date: 2012-04-13T08:28:39Z

[Term]
id: GO:1900369
name: negative regulation of RNA interference
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA interference." [GOC:kmv, GOC:TermGenie, PMID:22412382]
synonym: "down regulation of posttranscriptional gene silencing by siRNA" EXACT [GOC:TermGenie]
synonym: "down regulation of RNA interference" EXACT [GOC:TermGenie]
synonym: "down regulation of RNAi" EXACT [GOC:TermGenie]
synonym: "down-regulation of posttranscriptional gene silencing by siRNA" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA interference" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNAi" EXACT [GOC:TermGenie]
synonym: "downregulation of posttranscriptional gene silencing by siRNA" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA interference" EXACT [GOC:TermGenie]
synonym: "downregulation of RNAi" EXACT [GOC:TermGenie]
synonym: "inhibition of posttranscriptional gene silencing by siRNA" EXACT [GOC:TermGenie]
synonym: "inhibition of RNA interference" NARROW [GOC:TermGenie]
synonym: "inhibition of RNAi" EXACT [GOC:TermGenie]
synonym: "negative regulation of posttranscriptional gene silencing by siRNA" EXACT [GOC:TermGenie]
synonym: "negative regulation of RNAi" EXACT [GOC:TermGenie]
is_a: GO:0060149 ! negative regulation of posttranscriptional gene silencing
is_a: GO:0060967 ! negative regulation of gene silencing by RNA
is_a: GO:1900368 ! regulation of RNA interference
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016246 ! RNA interference
relationship: negatively_regulates GO:0016246 ! RNA interference
created_by: kmv
creation_date: 2012-04-13T08:28:50Z

[Term]
id: GO:1900370
name: positive regulation of RNA interference
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of RNA interference." [GOC:kmv, GOC:TermGenie, PMID:22412382]
synonym: "activation of posttranscriptional gene silencing by siRNA" EXACT [GOC:TermGenie]
synonym: "activation of RNA interference" NARROW [GOC:TermGenie]
synonym: "activation of RNAi" EXACT [GOC:TermGenie]
synonym: "positive regulation of posttranscriptional gene silencing by siRNA" EXACT [GOC:TermGenie]
synonym: "positive regulation of RNAi" EXACT [GOC:TermGenie]
synonym: "up regulation of posttranscriptional gene silencing by siRNA" EXACT [GOC:TermGenie]
synonym: "up regulation of RNA interference" EXACT [GOC:TermGenie]
synonym: "up regulation of RNAi" EXACT [GOC:TermGenie]
synonym: "up-regulation of posttranscriptional gene silencing by siRNA" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNA interference" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNAi" EXACT [GOC:TermGenie]
synonym: "upregulation of posttranscriptional gene silencing by siRNA" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA interference" EXACT [GOC:TermGenie]
synonym: "upregulation of RNAi" EXACT [GOC:TermGenie]
is_a: GO:0060148 ! positive regulation of posttranscriptional gene silencing
is_a: GO:1900368 ! regulation of RNA interference
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016246 ! RNA interference
relationship: positively_regulates GO:0016246 ! RNA interference
created_by: kmv
creation_date: 2012-04-13T08:29:00Z

[Term]
id: GO:1900371
name: regulation of purine nucleotide biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of purine nucleotide biosynthetic processes." [GOC:go_curators, GOC:TermGenie]
synonym: "regulation of purine nucleotide anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of purine nucleotide formation" EXACT [GOC:TermGenie]
synonym: "regulation of purine nucleotide synthesis" EXACT [GOC:TermGenie]
is_a: GO:0030808 ! regulation of nucleotide biosynthetic process
is_a: GO:1900542 ! regulation of purine nucleotide metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006164 ! purine nucleotide biosynthetic process
relationship: regulates GO:0006164 ! purine nucleotide biosynthetic process
created_by: krc
creation_date: 2012-04-17T12:32:07Z

[Term]
id: GO:1900372
name: negative regulation of purine nucleotide biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of purine nucleotide biosynthetic processes." [GOC:go_curators, GOC:TermGenie]
synonym: "down regulation of purine nucleotide anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of purine nucleotide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of purine nucleotide formation" EXACT [GOC:TermGenie]
synonym: "down regulation of purine nucleotide synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of purine nucleotide anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of purine nucleotide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of purine nucleotide formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of purine nucleotide synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of purine nucleotide anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of purine nucleotide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of purine nucleotide formation" EXACT [GOC:TermGenie]
synonym: "downregulation of purine nucleotide synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of purine nucleotide anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of purine nucleotide biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of purine nucleotide biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of purine nucleotide formation" EXACT [GOC:TermGenie]
synonym: "inhibition of purine nucleotide synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of purine nucleotide anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of purine nucleotide formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of purine nucleotide synthesis" EXACT [GOC:TermGenie]
is_a: GO:0030809 ! negative regulation of nucleotide biosynthetic process
is_a: GO:1900371 ! regulation of purine nucleotide biosynthetic process
is_a: GO:1900543 ! negative regulation of purine nucleotide metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006164 ! purine nucleotide biosynthetic process
relationship: negatively_regulates GO:0006164 ! purine nucleotide biosynthetic process
created_by: krc
creation_date: 2012-04-17T12:32:27Z

[Term]
id: GO:1900373
name: positive regulation of purine nucleotide biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of purine nucleotide biosynthetic processes." [GOC:go_curators, GOC:TermGenie]
synonym: "activation of purine nucleotide anabolism" EXACT [GOC:TermGenie]
synonym: "activation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of purine nucleotide biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of purine nucleotide formation" EXACT [GOC:TermGenie]
synonym: "activation of purine nucleotide synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of purine nucleotide anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of purine nucleotide formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of purine nucleotide synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of purine nucleotide anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of purine nucleotide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of purine nucleotide formation" EXACT [GOC:TermGenie]
synonym: "up regulation of purine nucleotide synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of purine nucleotide anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of purine nucleotide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of purine nucleotide formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of purine nucleotide synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of purine nucleotide anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of purine nucleotide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of purine nucleotide formation" EXACT [GOC:TermGenie]
synonym: "upregulation of purine nucleotide synthesis" EXACT [GOC:TermGenie]
is_a: GO:0030810 ! positive regulation of nucleotide biosynthetic process
is_a: GO:1900371 ! regulation of purine nucleotide biosynthetic process
is_a: GO:1900544 ! positive regulation of purine nucleotide metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006164 ! purine nucleotide biosynthetic process
relationship: positively_regulates GO:0006164 ! purine nucleotide biosynthetic process
created_by: krc
creation_date: 2012-04-17T12:32:37Z

[Term]
id: GO:1900374
name: positive regulation of mating type switching by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A regulation of transcription from RNA polymerase II promoter that results in positive regulation of mating type switching." [GOC:go_curators, GOC:TermGenie, PMID:8804308]
synonym: "activation of mating type switching by regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "stimulation of mating type switching by regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "up regulation of mating type switching by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of mating type switching by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of mating type switching by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0031496 ! positive regulation of mating type switching
intersection_of: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
intersection_of: positively_regulates GO:0007533 ! mating type switching
relationship: positively_regulates GO:0007533 ! mating type switching
created_by: krc
creation_date: 2012-04-17T12:39:56Z

[Term]
id: GO:1900375
name: positive regulation of inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A positive regulation of transcription from RNA polymerase II promoter that results in positive regulation of inositol biosynthetic process." [GOC:go_curators, GOC:TermGenie, PMID:2004420]
synonym: "activation of inositol anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "activation of inositol biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "activation of inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "activation of inositol formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "activation of inositol synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "activation of myo-inositol biosynthesis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "activation of myo-inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "activation of vitamin Bh biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "activation of vitamin Bh biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of inositol anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of inositol biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of inositol formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of inositol synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of myo-inositol biosynthesis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "positive regulation of myo-inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "positive regulation of vitamin Bh biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of vitamin Bh biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of inositol anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of inositol biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of inositol formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of inositol synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of myo-inositol biosynthesis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "up regulation of myo-inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "up regulation of vitamin Bh biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of vitamin Bh biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of inositol anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of inositol biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of inositol formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of inositol synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of myo-inositol biosynthesis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "up-regulation of myo-inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "up-regulation of vitamin Bh biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of vitamin Bh biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of inositol anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of inositol biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of inositol formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of inositol synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of myo-inositol biosynthesis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "upregulation of myo-inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "upregulation of vitamin Bh biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of vitamin Bh biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
is_a: GO:1900090 ! positive regulation of inositol biosynthetic process
is_a: GO:1900402 ! regulation of carbohydrate metabolic process by regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
intersection_of: positively_regulates GO:0006021 ! inositol biosynthetic process
relationship: positively_regulates GO:0006021 ! inositol biosynthetic process
created_by: krc
creation_date: 2012-04-17T12:45:48Z

[Term]
id: GO:1900376
name: regulation of secondary metabolite biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of secondary metabolite biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie]
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0043455 ! regulation of secondary metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044550 ! secondary metabolite biosynthetic process
relationship: regulates GO:0044550 ! secondary metabolite biosynthetic process
created_by: di
creation_date: 2012-04-17T01:55:23Z

[Term]
id: GO:1900377
name: negative regulation of secondary metabolite biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of secondary metabolite biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of secondary metabolite biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of secondary metabolite biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of secondary metabolite biosynthetic process" EXACT [GOC:TermGenie]
synonym: "inhibition of secondary metabolite biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of secondary metabolite biosynthetic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044550 ! secondary metabolite biosynthetic process
relationship: negatively_regulates GO:0044550 ! secondary metabolite biosynthetic process
created_by: di
creation_date: 2012-04-17T01:55:32Z

[Term]
id: GO:1900378
name: positive regulation of secondary metabolite biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of secondary metabolite biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of secondary metabolite biosynthetic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of secondary metabolite biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of secondary metabolite biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of secondary metabolite biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044550 ! secondary metabolite biosynthetic process
relationship: positively_regulates GO:0044550 ! secondary metabolite biosynthetic process
created_by: di
creation_date: 2012-04-17T01:55:41Z

[Term]
id: GO:1900379
name: regulation of asperthecin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of asperthecin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of asperthecin biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of asperthecin formation" EXACT [GOC:TermGenie]
synonym: "regulation of asperthecin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010566 ! regulation of ketone biosynthetic process
is_a: GO:0051196 ! regulation of coenzyme metabolic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0036184 ! asperthecin biosynthetic process
relationship: regulates GO:0036184 ! asperthecin biosynthetic process
created_by: di
creation_date: 2012-04-17T01:58:27Z

[Term]
id: GO:1900380
name: negative regulation of asperthecin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of asperthecin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of asperthecin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of asperthecin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of asperthecin formation" EXACT [GOC:TermGenie]
synonym: "down regulation of asperthecin synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of asperthecin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of asperthecin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of asperthecin formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of asperthecin synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of asperthecin biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of asperthecin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of asperthecin formation" EXACT [GOC:TermGenie]
synonym: "downregulation of asperthecin synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of asperthecin biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of asperthecin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of asperthecin formation" EXACT [GOC:TermGenie]
synonym: "inhibition of asperthecin synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of asperthecin biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of asperthecin formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of asperthecin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0051198 ! negative regulation of coenzyme metabolic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900379 ! regulation of asperthecin biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0036184 ! asperthecin biosynthetic process
relationship: negatively_regulates GO:0036184 ! asperthecin biosynthetic process
created_by: di
creation_date: 2012-04-17T01:58:37Z

[Term]
id: GO:1900381
name: positive regulation of asperthecin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of asperthecin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of asperthecin biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of asperthecin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of asperthecin formation" EXACT [GOC:TermGenie]
synonym: "activation of asperthecin synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of asperthecin biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of asperthecin formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of asperthecin synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of asperthecin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of asperthecin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of asperthecin formation" EXACT [GOC:TermGenie]
synonym: "up regulation of asperthecin synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of asperthecin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of asperthecin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of asperthecin formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of asperthecin synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of asperthecin biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of asperthecin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of asperthecin formation" EXACT [GOC:TermGenie]
synonym: "upregulation of asperthecin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0051197 ! positive regulation of coenzyme metabolic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900379 ! regulation of asperthecin biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0036184 ! asperthecin biosynthetic process
relationship: positively_regulates GO:0036184 ! asperthecin biosynthetic process
created_by: di
creation_date: 2012-04-17T01:58:45Z

[Term]
id: GO:1900382
name: regulation of thiamine biosynthetic process by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A regulation of transcription from RNA polymerase II promoter that results in regulation of thiamine biosynthetic process." [GOC:mah, GOC:TermGenie, PMID:16874521]
synonym: "regulation of thiamin biosynthetic process by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of thiamine anabolism by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of thiamine biosynthesis by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of thiamine formation by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of thiamine synthesis by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0070623 ! regulation of thiamine biosynthetic process
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: regulates GO:0100016 ! regulation of thiamine biosynthetic process by transcription from RNA polymerase II promoter
relationship: regulates GO:0100016 ! regulation of thiamine biosynthetic process by transcription from RNA polymerase II promoter
created_by: mah
creation_date: 2012-04-17T04:05:24Z

[Term]
id: GO:1900383
name: regulation of synaptic plasticity by receptor localization to synapse
namespace: biological_process
def: "Any process that modulates synaptic plasticity, the ability of synapses to change as circumstances require, via receptor localization to the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. Processes may include receptor transport to, and/or maintenance at, the synapse." [GOC:kmv, GOC:TermGenie, PMID:22464329]
synonym: "regulation of synaptic plasticity by receptor localisation to synapse" EXACT [GOC:TermGenie]
is_a: GO:0097120 ! receptor localization to synapse
created_by: kmv
creation_date: 2012-04-17T04:44:37Z

[Term]
id: GO:1900384
name: regulation of flavonol biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of flavonol biosynthetic process." [GOC:TermGenie]
is_a: GO:0009962 ! regulation of flavonoid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051555 ! flavonol biosynthetic process
relationship: regulates GO:0051555 ! flavonol biosynthetic process
created_by: tb
creation_date: 2012-04-17T10:22:49Z

[Term]
id: GO:1900385
name: negative regulation of flavonol biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of flavonol biosynthetic process." [GOC:TermGenie]
synonym: "down regulation of flavonol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of flavonol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of flavonol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "inhibition of flavonol biosynthetic process" NARROW [GOC:TermGenie]
is_a: GO:0009964 ! negative regulation of flavonoid biosynthetic process
is_a: GO:1900384 ! regulation of flavonol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051555 ! flavonol biosynthetic process
relationship: negatively_regulates GO:0051555 ! flavonol biosynthetic process
created_by: tb
creation_date: 2012-04-17T10:22:59Z

[Term]
id: GO:1900386
name: positive regulation of flavonol biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of flavonol biosynthetic process." [GOC:TermGenie]
synonym: "activation of flavonol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "up regulation of flavonol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of flavonol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of flavonol biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0009963 ! positive regulation of flavonoid biosynthetic process
is_a: GO:1900384 ! regulation of flavonol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051555 ! flavonol biosynthetic process
relationship: positively_regulates GO:0051555 ! flavonol biosynthetic process
created_by: tb
creation_date: 2012-04-17T10:23:09Z

[Term]
id: GO:1900387
name: negative regulation of cell-cell adhesion by negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A negative regulation of transcription from RNA polymerase II promoter that results in negative regulation of cell-cell adhesion." [GOC:BHF, GOC:TermGenie, PMID:15737616]
is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
is_a: GO:0022408 ! negative regulation of cell-cell adhesion
intersection_of: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
intersection_of: negatively_regulates GO:0098609 ! cell-cell adhesion
relationship: negatively_regulates GO:0098609 ! cell-cell adhesion
created_by: pr
creation_date: 2012-04-18T12:01:19Z

[Term]
id: GO:1900388
name: obsolete regulation of vesicle-mediated transport by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of vesicle-mediated transport." [GOC:mah, GOC:TermGenie, PMID:18622392]
comment: This term was made obsolete because there is no evidence that  vesicle-mediated transport is regulated transcriptionally.
synonym: "regulation of vesicle-mediated transport by regulation of transcription from RNA polymerase II promoter" EXACT []
is_obsolete: true
created_by: mah
creation_date: 2012-04-18T03:52:29Z

[Term]
id: GO:1900389
name: regulation of glucose import by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A regulation of transcription from RNA polymerase II promoter that results in regulation of glucose import." [GOC:mah, GOC:TermGenie, PMID:18622392]
synonym: "regulation of glucose uptake by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0046324 ! regulation of glucose import
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: regulates GO:0100018 ! regulation of glucose import by transcription from RNA polymerase II promoter
relationship: regulates GO:0100018 ! regulation of glucose import by transcription from RNA polymerase II promoter
created_by: mah
creation_date: 2012-04-18T03:52:43Z

[Term]
id: GO:1900390
name: regulation of iron ion import
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of iron ion import." [GOC:TermGenie]
synonym: "regulation of iron import" EXACT [GOC:TermGenie]
is_a: GO:0034756 ! regulation of iron ion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097286 ! iron ion import
relationship: regulates GO:0097286 ! iron ion import
created_by: mah
creation_date: 2012-04-18T04:00:14Z

[Term]
id: GO:1900391
name: regulation of cAMP-mediated signaling by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A regulation of transcription from RNA polymerase II promoter that results in regulation of cAMP-mediated signaling." [GOC:mah, GOC:TermGenie, PMID:15448137]
synonym: "regulation of cAMP-mediated signalling by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0043949 ! regulation of cAMP-mediated signaling
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: regulates GO:0100019 ! regulation of cAMP-mediated signaling by transcription from RNA polymerase II promoter
relationship: regulates GO:0100019 ! regulation of cAMP-mediated signaling by transcription from RNA polymerase II promoter
created_by: mah
creation_date: 2012-04-18T04:19:39Z

[Term]
id: GO:1900392
name: regulation of transport by negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A negative regulation of transcription from RNA polymerase II promoter that results in regulation of transport." [GOC:mah, GOC:TermGenie, PMID:17446861]
is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: negatively_regulates GO:0100020 ! regulation of transport by transcription from RNA polymerase II promoter
relationship: negatively_regulates GO:0100020 ! regulation of transport by transcription from RNA polymerase II promoter
created_by: mah
creation_date: 2012-04-18T04:20:25Z

[Term]
id: GO:1900393
name: regulation of iron ion transport by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A regulation of transcription from RNA polymerase II promoter that results in regulation of iron ion transport." [GOC:mah, GOC:TermGenie, PMID:11956219]
synonym: "regulation of Fe transport by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of iron transport by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0034756 ! regulation of iron ion transport
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: regulates GO:0100021 ! regulation of iron ion transport by transcription from RNA polymerase II promoter
relationship: regulates GO:0100021 ! regulation of iron ion transport by transcription from RNA polymerase II promoter
created_by: mah
creation_date: 2012-04-18T04:20:39Z

[Term]
id: GO:1900394
name: regulation of kojic acid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of kojic acid biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process" EXACT [GOC:TermGenie]
synonym: "regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation" EXACT [GOC:TermGenie]
synonym: "regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis" EXACT [GOC:TermGenie]
synonym: "regulation of C6H6O4 anabolism" RELATED [GOC:TermGenie]
synonym: "regulation of C6H6O4 biosynthesis" RELATED [GOC:TermGenie]
synonym: "regulation of C6H6O4 biosynthetic process" RELATED [GOC:TermGenie]
synonym: "regulation of C6H6O4 formation" RELATED [GOC:TermGenie]
synonym: "regulation of C6H6O4 synthesis" RELATED [GOC:TermGenie]
synonym: "regulation of kojic acid anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of kojic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of kojic acid formation" EXACT [GOC:TermGenie]
synonym: "regulation of kojic acid synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010566 ! regulation of ketone biosynthetic process
is_a: GO:1902930 ! regulation of alcohol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:2001317 ! kojic acid biosynthetic process
relationship: regulates GO:2001317 ! kojic acid biosynthetic process
created_by: di
creation_date: 2012-04-18T04:19:53Z

[Term]
id: GO:1900395
name: negative regulation of kojic acid biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of kojic acid biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation" EXACT [GOC:TermGenie]
synonym: "down regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of C6H6O4 anabolism" RELATED [GOC:TermGenie]
synonym: "down regulation of C6H6O4 biosynthesis" RELATED [GOC:TermGenie]
synonym: "down regulation of C6H6O4 biosynthetic process" RELATED [GOC:TermGenie]
synonym: "down regulation of C6H6O4 formation" RELATED [GOC:TermGenie]
synonym: "down regulation of C6H6O4 synthesis" RELATED [GOC:TermGenie]
synonym: "down regulation of kojic acid anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of kojic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of kojic acid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of kojic acid formation" EXACT [GOC:TermGenie]
synonym: "down regulation of kojic acid synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of C6H6O4 anabolism" RELATED [GOC:TermGenie]
synonym: "down-regulation of C6H6O4 biosynthesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of C6H6O4 biosynthetic process" RELATED [GOC:TermGenie]
synonym: "down-regulation of C6H6O4 formation" RELATED [GOC:TermGenie]
synonym: "down-regulation of C6H6O4 synthesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of kojic acid anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of kojic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of kojic acid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of kojic acid formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of kojic acid synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation" EXACT [GOC:TermGenie]
synonym: "downregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of C6H6O4 anabolism" RELATED [GOC:TermGenie]
synonym: "downregulation of C6H6O4 biosynthesis" RELATED [GOC:TermGenie]
synonym: "downregulation of C6H6O4 biosynthetic process" RELATED [GOC:TermGenie]
synonym: "downregulation of C6H6O4 formation" RELATED [GOC:TermGenie]
synonym: "downregulation of C6H6O4 synthesis" RELATED [GOC:TermGenie]
synonym: "downregulation of kojic acid anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of kojic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of kojic acid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of kojic acid formation" EXACT [GOC:TermGenie]
synonym: "downregulation of kojic acid synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process" EXACT [GOC:TermGenie]
synonym: "inhibition of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation" EXACT [GOC:TermGenie]
synonym: "inhibition of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of C6H6O4 anabolism" RELATED [GOC:TermGenie]
synonym: "inhibition of C6H6O4 biosynthesis" RELATED [GOC:TermGenie]
synonym: "inhibition of C6H6O4 biosynthetic process" RELATED [GOC:TermGenie]
synonym: "inhibition of C6H6O4 formation" RELATED [GOC:TermGenie]
synonym: "inhibition of C6H6O4 synthesis" RELATED [GOC:TermGenie]
synonym: "inhibition of kojic acid anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of kojic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of kojic acid biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of kojic acid formation" EXACT [GOC:TermGenie]
synonym: "inhibition of kojic acid synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of C6H6O4 anabolism" RELATED [GOC:TermGenie]
synonym: "negative regulation of C6H6O4 biosynthesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of C6H6O4 biosynthetic process" RELATED [GOC:TermGenie]
synonym: "negative regulation of C6H6O4 formation" RELATED [GOC:TermGenie]
synonym: "negative regulation of C6H6O4 synthesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of kojic acid anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of kojic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of kojic acid formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of kojic acid synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:1900394 ! regulation of kojic acid biosynthetic process
is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:2001317 ! kojic acid biosynthetic process
relationship: negatively_regulates GO:2001317 ! kojic acid biosynthetic process
created_by: di
creation_date: 2012-04-18T04:20:03Z

[Term]
id: GO:1900396
name: positive regulation of kojic acid biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of kojic acid biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism" EXACT [GOC:TermGenie]
synonym: "activation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process" EXACT [GOC:TermGenie]
synonym: "activation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation" EXACT [GOC:TermGenie]
synonym: "activation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis" EXACT [GOC:TermGenie]
synonym: "activation of C6H6O4 anabolism" RELATED [GOC:TermGenie]
synonym: "activation of C6H6O4 biosynthesis" RELATED [GOC:TermGenie]
synonym: "activation of C6H6O4 biosynthetic process" RELATED [GOC:TermGenie]
synonym: "activation of C6H6O4 formation" RELATED [GOC:TermGenie]
synonym: "activation of C6H6O4 synthesis" RELATED [GOC:TermGenie]
synonym: "activation of kojic acid anabolism" EXACT [GOC:TermGenie]
synonym: "activation of kojic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of kojic acid biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of kojic acid formation" EXACT [GOC:TermGenie]
synonym: "activation of kojic acid synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of C6H6O4 anabolism" RELATED [GOC:TermGenie]
synonym: "positive regulation of C6H6O4 biosynthesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of C6H6O4 biosynthetic process" RELATED [GOC:TermGenie]
synonym: "positive regulation of C6H6O4 formation" RELATED [GOC:TermGenie]
synonym: "positive regulation of C6H6O4 synthesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of kojic acid anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of kojic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of kojic acid formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of kojic acid synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation" EXACT [GOC:TermGenie]
synonym: "up regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of C6H6O4 anabolism" RELATED [GOC:TermGenie]
synonym: "up regulation of C6H6O4 biosynthesis" RELATED [GOC:TermGenie]
synonym: "up regulation of C6H6O4 biosynthetic process" RELATED [GOC:TermGenie]
synonym: "up regulation of C6H6O4 formation" RELATED [GOC:TermGenie]
synonym: "up regulation of C6H6O4 synthesis" RELATED [GOC:TermGenie]
synonym: "up regulation of kojic acid anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of kojic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of kojic acid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of kojic acid formation" EXACT [GOC:TermGenie]
synonym: "up regulation of kojic acid synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of C6H6O4 anabolism" RELATED [GOC:TermGenie]
synonym: "up-regulation of C6H6O4 biosynthesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of C6H6O4 biosynthetic process" RELATED [GOC:TermGenie]
synonym: "up-regulation of C6H6O4 formation" RELATED [GOC:TermGenie]
synonym: "up-regulation of C6H6O4 synthesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of kojic acid anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of kojic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of kojic acid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of kojic acid formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of kojic acid synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation" EXACT [GOC:TermGenie]
synonym: "upregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of C6H6O4 anabolism" RELATED [GOC:TermGenie]
synonym: "upregulation of C6H6O4 biosynthesis" RELATED [GOC:TermGenie]
synonym: "upregulation of C6H6O4 biosynthetic process" RELATED [GOC:TermGenie]
synonym: "upregulation of C6H6O4 formation" RELATED [GOC:TermGenie]
synonym: "upregulation of C6H6O4 synthesis" RELATED [GOC:TermGenie]
synonym: "upregulation of kojic acid anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of kojic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of kojic acid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of kojic acid formation" EXACT [GOC:TermGenie]
synonym: "upregulation of kojic acid synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:1900394 ! regulation of kojic acid biosynthetic process
is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:2001317 ! kojic acid biosynthetic process
relationship: positively_regulates GO:2001317 ! kojic acid biosynthetic process
created_by: di
creation_date: 2012-04-18T04:20:11Z

[Term]
id: GO:1900397
name: regulation of pyrimidine nucleotide biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pyrimidine nucleotide biosynthetic process." [GOC:TermGenie]
synonym: "regulation of pyrimidine nucleotide anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of pyrimidine nucleotide biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of pyrimidine nucleotide formation" EXACT [GOC:TermGenie]
synonym: "regulation of pyrimidine nucleotide synthesis" EXACT [GOC:TermGenie]
is_a: GO:0030808 ! regulation of nucleotide biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006221 ! pyrimidine nucleotide biosynthetic process
relationship: regulates GO:0006221 ! pyrimidine nucleotide biosynthetic process
created_by: jh
creation_date: 2012-04-19T01:05:31Z

[Term]
id: GO:1900398
name: negative regulation of pyrimidine nucleotide biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of pyrimidine nucleotide biosynthetic process." [GOC:TermGenie]
synonym: "down regulation of pyrimidine nucleotide anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of pyrimidine nucleotide biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of pyrimidine nucleotide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of pyrimidine nucleotide formation" EXACT [GOC:TermGenie]
synonym: "down regulation of pyrimidine nucleotide synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of pyrimidine nucleotide anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of pyrimidine nucleotide biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of pyrimidine nucleotide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of pyrimidine nucleotide formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of pyrimidine nucleotide synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of pyrimidine nucleotide anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of pyrimidine nucleotide biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of pyrimidine nucleotide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of pyrimidine nucleotide formation" EXACT [GOC:TermGenie]
synonym: "downregulation of pyrimidine nucleotide synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of pyrimidine nucleotide anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of pyrimidine nucleotide biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of pyrimidine nucleotide biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of pyrimidine nucleotide formation" EXACT [GOC:TermGenie]
synonym: "inhibition of pyrimidine nucleotide synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of pyrimidine nucleotide anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of pyrimidine nucleotide biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of pyrimidine nucleotide formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of pyrimidine nucleotide synthesis" EXACT [GOC:TermGenie]
is_a: GO:0030809 ! negative regulation of nucleotide biosynthetic process
is_a: GO:1900397 ! regulation of pyrimidine nucleotide biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006221 ! pyrimidine nucleotide biosynthetic process
relationship: negatively_regulates GO:0006221 ! pyrimidine nucleotide biosynthetic process
created_by: jh
creation_date: 2012-04-19T01:05:41Z

[Term]
id: GO:1900399
name: positive regulation of pyrimidine nucleotide biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pyrimidine nucleotide biosynthetic process." [GOC:TermGenie]
synonym: "activation of pyrimidine nucleotide anabolism" EXACT [GOC:TermGenie]
synonym: "activation of pyrimidine nucleotide biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of pyrimidine nucleotide biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of pyrimidine nucleotide formation" EXACT [GOC:TermGenie]
synonym: "activation of pyrimidine nucleotide synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of pyrimidine nucleotide anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of pyrimidine nucleotide biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of pyrimidine nucleotide formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of pyrimidine nucleotide synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of pyrimidine nucleotide anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of pyrimidine nucleotide biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of pyrimidine nucleotide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of pyrimidine nucleotide formation" EXACT [GOC:TermGenie]
synonym: "up regulation of pyrimidine nucleotide synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of pyrimidine nucleotide anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of pyrimidine nucleotide biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of pyrimidine nucleotide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of pyrimidine nucleotide formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of pyrimidine nucleotide synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of pyrimidine nucleotide anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of pyrimidine nucleotide biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of pyrimidine nucleotide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of pyrimidine nucleotide formation" EXACT [GOC:TermGenie]
synonym: "upregulation of pyrimidine nucleotide synthesis" EXACT [GOC:TermGenie]
is_a: GO:0030810 ! positive regulation of nucleotide biosynthetic process
is_a: GO:1900397 ! regulation of pyrimidine nucleotide biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006221 ! pyrimidine nucleotide biosynthetic process
relationship: positively_regulates GO:0006221 ! pyrimidine nucleotide biosynthetic process
created_by: jh
creation_date: 2012-04-19T01:05:50Z

[Term]
id: GO:1900400
name: regulation of iron ion import by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A regulation of transcription from RNA polymerase II promoter that results in regulation of iron ion import." [GOC:mah, GOC:TermGenie, PMID:18622392]
synonym: "regulation of iron import by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_a: GO:1900390 ! regulation of iron ion import
is_a: GO:1900393 ! regulation of iron ion transport by regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: regulates GO:0100022 ! regulation of iron ion import by transcription from RNA polymerase II promoter
relationship: regulates GO:0100022 ! regulation of iron ion import by transcription from RNA polymerase II promoter
created_by: mah
creation_date: 2012-04-20T02:34:12Z

[Term]
id: GO:1900401
name: regulation of meiosis by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A regulation of transcription from RNA polymerase II promoter that results in regulation of meiosis." [GOC:mah, GOC:TermGenie, PMID:12161753]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0040020 ! regulation of meiotic nuclear division
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: regulates GO:0100023 ! regulation of meiotic nuclear division by transcription from RNA polymerase II promoter
relationship: regulates GO:0100023 ! regulation of meiotic nuclear division by transcription from RNA polymerase II promoter
created_by: mah
creation_date: 2012-04-20T02:45:12Z

[Term]
id: GO:1900402
name: regulation of carbohydrate metabolic process by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A regulation of transcription from RNA polymerase II promoter that results in regulation of carbohydrate metabolic process." [GOC:mah, GOC:TermGenie, PMID:16408318]
synonym: "regulation of carbohydrate metabolism by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_a: GO:0006109 ! regulation of carbohydrate metabolic process
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: regulates GO:0100024 ! regulation of carbohydrate metabolic process by transcription from RNA polymerase II promoter
relationship: regulates GO:0100024 ! regulation of carbohydrate metabolic process by transcription from RNA polymerase II promoter
created_by: mah
creation_date: 2012-04-20T02:45:27Z

[Term]
id: GO:1900403
name: negative regulation of cellular amino acid biosynthetic process by negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A negative regulation of transcription from RNA polymerase II promoter that results in negative regulation of cellular amino acid biosynthetic process." [GOC:mah, GOC:TermGenie, PMID:17446861]
synonym: "negative regulation of amino acid biosynthetic process by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of cellular amino acid anabolism by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of cellular amino acid biosynthesis by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of cellular amino acid formation by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of cellular amino acid synthesis by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_a: GO:0072365 ! regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter
is_a: GO:2000283 ! negative regulation of cellular amino acid biosynthetic process
intersection_of: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
intersection_of: negatively_regulates GO:0008652 ! cellular amino acid biosynthetic process
relationship: negatively_regulates GO:0008652 ! cellular amino acid biosynthetic process
created_by: mah
creation_date: 2012-04-20T02:45:42Z

[Term]
id: GO:1900404
name: positive regulation of DNA repair by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A positive regulation of transcription from RNA polymerase II promoter that results in positive regulation of DNA repair." [GOC:mah, GOC:TermGenie, PMID:20299455]
synonym: "activation of DNA repair by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "stimulation of DNA repair by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "up regulation of DNA repair by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA repair by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA repair by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_a: GO:0045739 ! positive regulation of DNA repair
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: positively_regulates GO:0100026 ! positive regulation of DNA repair by transcription from RNA polymerase II promoter
relationship: positively_regulates GO:0100026 ! positive regulation of DNA repair by transcription from RNA polymerase II promoter
created_by: mah
creation_date: 2012-04-20T02:45:56Z

[Term]
id: GO:1900405
name: regulation of cell separation after cytokinesis by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A regulation of transcription from RNA polymerase II promoter that results in regulation of  cell separation after cytokinesis." [GOC:mah, GOC:TermGenie, PMID:10491317, PMID:12665550]
synonym: "regulation of cytokinetic cell separation by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0010590 ! regulation of cell separation after cytokinesis
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: regulates GO:0100027 ! regulation of cell separation after cytokinesis by transcription from RNA polymerase II promoter
relationship: regulates GO:0100027 ! regulation of cell separation after cytokinesis by transcription from RNA polymerase II promoter
created_by: mah
creation_date: 2012-04-20T02:46:10Z

[Term]
id: GO:1900406
name: regulation of conjugation with cellular fusion by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A regulation of transcription from RNA polymerase II promoter that results in regulation of conjugation with cellular fusion." [GOC:mah, GOC:TermGenie, PMID:1112904]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0031137 ! regulation of conjugation with cellular fusion
intersection_of: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
intersection_of: regulates GO:0000747 ! conjugation with cellular fusion
relationship: regulates GO:0000747 ! conjugation with cellular fusion
created_by: mah
creation_date: 2012-04-20T02:46:24Z

[Term]
id: GO:1900407
name: regulation of cellular response to oxidative stress
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular response to oxidative stress." [GOC:mah, GOC:TermGenie]
synonym: "regulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie]
is_a: GO:0080135 ! regulation of cellular response to stress
is_a: GO:1902882 ! regulation of response to oxidative stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034599 ! cellular response to oxidative stress
relationship: regulates GO:0034599 ! cellular response to oxidative stress
created_by: mah
creation_date: 2012-04-20T03:30:52Z

[Term]
id: GO:1900408
name: negative regulation of cellular response to oxidative stress
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to oxidative stress." [GOC:mah, GOC:TermGenie]
synonym: "down regulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "down regulation of cellular response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "down-regulation of cellular response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "downregulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "downregulation of cellular response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "inhibition of adaptive response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "negative regulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:1900407 ! regulation of cellular response to oxidative stress
is_a: GO:1902883 ! negative regulation of response to oxidative stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034599 ! cellular response to oxidative stress
relationship: negatively_regulates GO:0034599 ! cellular response to oxidative stress
created_by: mah
creation_date: 2012-04-20T03:31:05Z

[Term]
id: GO:1900409
name: positive regulation of cellular response to oxidative stress
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellular response to oxidative stress." [GOC:mah, GOC:TermGenie]
synonym: "activation of adaptive response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "activation of cellular response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "positive regulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "up regulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "up regulation of cellular response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "up-regulation of cellular response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "upregulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "upregulation of cellular response to oxidative stress" EXACT [GOC:TermGenie]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:1900407 ! regulation of cellular response to oxidative stress
is_a: GO:1902884 ! positive regulation of response to oxidative stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034599 ! cellular response to oxidative stress
relationship: positively_regulates GO:0034599 ! cellular response to oxidative stress
created_by: mah
creation_date: 2012-04-20T03:31:16Z

[Term]
id: GO:1900410
name: regulation of histone modification by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A regulation of transcription from RNA polymerase II promoter that results in regulation of histone modification." [GOC:mah, GOC:TermGenie]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0031056 ! regulation of histone modification
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: regulates GO:0100029 ! regulation of histone modification by transcription from RNA polymerase II promoter
relationship: regulates GO:0100029 ! regulation of histone modification by transcription from RNA polymerase II promoter
created_by: mah
creation_date: 2012-04-20T03:35:08Z

[Term]
id: GO:1900411
name: regulation of histone acetylation by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A regulation of transcription from RNA polymerase II promoter that results in regulation of histone acetylation." [GOC:mah, GOC:TermGenie, PMID:15218150]
is_a: GO:0035065 ! regulation of histone acetylation
is_a: GO:0072364 ! regulation of cellular ketone metabolic process by regulation of transcription from RNA polymerase II promoter
is_a: GO:1900410 ! regulation of histone modification by regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
intersection_of: regulates GO:0016573 ! histone acetylation
relationship: regulates GO:0016573 ! histone acetylation
created_by: mah
creation_date: 2012-04-20T03:35:22Z

[Term]
id: GO:1900412
name: regulation of histone methylation by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A regulation of transcription from RNA polymerase II promoter that results in regulation of histone methylation." [GOC:mah, GOC:TermGenie, PMID:15218150]
is_a: GO:0031060 ! regulation of histone methylation
is_a: GO:1900410 ! regulation of histone modification by regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
intersection_of: regulates GO:0016571 ! histone methylation
relationship: regulates GO:0016571 ! histone methylation
created_by: mah
creation_date: 2012-04-20T03:35:36Z

[Term]
id: GO:1900413
name: positive regulation of phospholipid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A positive regulation of transcription from RNA polymerase II promoter that results in positive regulation of phospholipid biosynthetic process." [GOC:mah, GOC:TermGenie, PMID:16537923]
synonym: "positive regulation of phospholipid biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of phospholipid synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
is_a: GO:0071073 ! positive regulation of phospholipid biosynthetic process
intersection_of: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
intersection_of: positively_regulates GO:0008654 ! phospholipid biosynthetic process
relationship: positively_regulates GO:0008654 ! phospholipid biosynthetic process
created_by: mah
creation_date: 2012-04-20T03:41:58Z

[Term]
id: GO:1900414
name: regulation of cytokinesis by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A regulation of transcription from RNA polymerase II promoter that results in regulation of cytokinesis." [GOC:mah, GOC:TermGenie, PMID:15509866]
is_a: GO:0032465 ! regulation of cytokinesis
created_by: mah
creation_date: 2012-04-20T03:42:13Z

[Term]
id: GO:1900415
name: regulation of fungal-type cell wall biogenesis by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A regulation of transcription from RNA polymerase II promoter that results in regulation of fungal-type cell wall biogenesis." [GOC:mah, GOC:TermGenie, PMID:15509866]
synonym: "regulation of chitin- and beta-glucan-containing cell wall biogenesis by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0032995 ! regulation of fungal-type cell wall biogenesis
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: regulates GO:0100033 ! regulation of fungal-type cell wall biogenesis by transcription from RNA polymerase II promoter
relationship: regulates GO:0100033 ! regulation of fungal-type cell wall biogenesis by transcription from RNA polymerase II promoter
created_by: mah
creation_date: 2012-04-20T03:42:27Z

[Term]
id: GO:1900416
name: regulation of 4,6-pyruvylated galactose residue biosynthetic process by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A regulation of transcription from RNA polymerase II promoter that results in regulation of 4,6-pyruvylated galactose residue biosynthetic process." [GOC:mah, GOC:TermGenie, PMID:15173185]
is_a: GO:0060634 ! regulation of 4,6-pyruvylated galactose residue biosynthetic process
is_a: GO:1900402 ! regulation of carbohydrate metabolic process by regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: regulates GO:0100034 ! regulation of 4,6-pyruvylated galactose residue biosynthetic process by transcription from RNA polymerase II promoter
relationship: regulates GO:0100034 ! regulation of 4,6-pyruvylated galactose residue biosynthetic process by transcription from RNA polymerase II promoter
created_by: mah
creation_date: 2012-04-20T03:42:41Z

[Term]
id: GO:1900417
name: negative regulation of transmembrane transport by negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A negative regulation of transcription from RNA polymerase II promoter that results in negative regulation of transmembrane transport." [GOC:mah, GOC:TermGenie, PMID:20404084]
is_a: GO:0034763 ! negative regulation of transmembrane transport
is_a: GO:0034764 ! positive regulation of transmembrane transport
is_a: GO:1900392 ! regulation of transport by negative regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: negatively_regulates GO:0100035 ! negative regulation of transmembrane transport by transcription from RNA polymerase II promoter
relationship: negatively_regulates GO:0100035 ! negative regulation of transmembrane transport by transcription from RNA polymerase II promoter
created_by: mah
creation_date: 2012-04-20T03:42:55Z

[Term]
id: GO:1900418
name: positive regulation of purine nucleotide biosynthetic process by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A positive regulation of transcription from RNA polymerase II promoter that results in positive regulation of purine nucleotide biosynthetic process." [GOC:curators, GOC:TermGenie, PMID:17573544]
synonym: "activation of purine nucleotide anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "activation of purine nucleotide biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "activation of purine nucleotide biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "activation of purine nucleotide formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "activation of purine nucleotide synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of purine nucleotide anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of purine nucleotide biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of purine nucleotide formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of purine nucleotide synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of purine nucleotide anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of purine nucleotide biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of purine nucleotide biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of purine nucleotide formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of purine nucleotide synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of purine nucleotide anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of purine nucleotide biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of purine nucleotide biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of purine nucleotide formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of purine nucleotide synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of purine nucleotide anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of purine nucleotide biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of purine nucleotide biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of purine nucleotide formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of purine nucleotide synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
is_a: GO:1900373 ! positive regulation of purine nucleotide biosynthetic process
intersection_of: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
intersection_of: positively_regulates GO:0006164 ! purine nucleotide biosynthetic process
relationship: positively_regulates GO:0006164 ! purine nucleotide biosynthetic process
created_by: krc
creation_date: 2012-04-20T10:13:58Z

[Term]
id: GO:1900419
name: regulation of cellular alcohol catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular alcohol catabolic process." [GOC:TermGenie]
is_a: GO:0031329 ! regulation of cellular catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044109 ! cellular alcohol catabolic process
relationship: regulates GO:0044109 ! cellular alcohol catabolic process
created_by: krc
creation_date: 2012-04-20T10:21:18Z

[Term]
id: GO:1900420
name: negative regulation of cellular alcohol catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular alcohol catabolic process." [GOC:TermGenie]
synonym: "down regulation of cellular alcohol catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular alcohol catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular alcohol catabolic process" EXACT [GOC:TermGenie]
synonym: "inhibition of cellular alcohol catabolic process" NARROW [GOC:TermGenie]
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:1900419 ! regulation of cellular alcohol catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044109 ! cellular alcohol catabolic process
relationship: negatively_regulates GO:0044109 ! cellular alcohol catabolic process
created_by: krc
creation_date: 2012-04-20T10:21:28Z

[Term]
id: GO:1900421
name: positive regulation of cellular alcohol catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellular alcohol catabolic process." [GOC:TermGenie]
synonym: "activation of cellular alcohol catabolic process" NARROW [GOC:TermGenie]
synonym: "up regulation of cellular alcohol catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular alcohol catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular alcohol catabolic process" EXACT [GOC:TermGenie]
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:1900419 ! regulation of cellular alcohol catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044109 ! cellular alcohol catabolic process
relationship: positively_regulates GO:0044109 ! cellular alcohol catabolic process
created_by: krc
creation_date: 2012-04-20T10:21:46Z

[Term]
id: GO:1900422
name: positive regulation of cellular alcohol catabolic process by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A positive regulation of transcription from RNA polymerase II promoter that results in positive regulation of cellular alcohol catabolic process." [GOC:curators, GOC:TermGenie, PMID:3305157, PMID:8221926]
synonym: "activation of cellular alcohol catabolic process by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "up regulation of cellular alcohol catabolic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular alcohol catabolic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular alcohol catabolic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
is_a: GO:1900421 ! positive regulation of cellular alcohol catabolic process
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: positively_regulates GO:0100037 ! positive regulation of cellular alcohol catabolic process by transcription from RNA polymerase II promoter
relationship: positively_regulates GO:0100037 ! positive regulation of cellular alcohol catabolic process by transcription from RNA polymerase II promoter
created_by: krc
creation_date: 2012-04-24T05:13:25Z

[Term]
id: GO:1900423
name: positive regulation of mating type switching by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A positive regulation of transcription from RNA polymerase II promoter that results in positive regulation of mating type switching." [GOC:TermGenie, PMID:8804308]
synonym: "activation of mating type switching by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "stimulation of mating type switching by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "up regulation of mating type switching by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of mating type switching by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of mating type switching by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
is_a: GO:1900374 ! positive regulation of mating type switching by regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: positively_regulates GO:0100014 ! positive regulation of mating type switching by transcription from RNA polymerase II promoter
relationship: positively_regulates GO:0100014 ! positive regulation of mating type switching by transcription from RNA polymerase II promoter
created_by: krc
creation_date: 2012-04-24T05:50:51Z

[Term]
id: GO:1900424
name: regulation of defense response to bacterium
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of defense response to bacterium." [GOC:TermGenie, PMID:22346749]
synonym: "regulation of antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "regulation of defence response to bacteria" EXACT [GOC:TermGenie]
synonym: "regulation of defence response to bacterium" EXACT [GOC:TermGenie]
synonym: "regulation of defense response to bacteria" EXACT [GOC:TermGenie]
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0032101 ! regulation of response to external stimulus
is_a: GO:0043900 ! regulation of multi-organism process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042742 ! defense response to bacterium
relationship: regulates GO:0042742 ! defense response to bacterium
created_by: dhl
creation_date: 2012-04-24T10:12:43Z

[Term]
id: GO:1900425
name: negative regulation of defense response to bacterium
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of defense response to bacterium." [GOC:TermGenie, PMID:22346749]
synonym: "down regulation of antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "down regulation of defence response to bacteria" EXACT [GOC:TermGenie]
synonym: "down regulation of defence response to bacterium" EXACT [GOC:TermGenie]
synonym: "down regulation of defense response to bacteria" EXACT [GOC:TermGenie]
synonym: "down regulation of defense response to bacterium" EXACT [GOC:TermGenie]
synonym: "down-regulation of antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of defence response to bacteria" EXACT [GOC:TermGenie]
synonym: "down-regulation of defence response to bacterium" EXACT [GOC:TermGenie]
synonym: "down-regulation of defense response to bacteria" EXACT [GOC:TermGenie]
synonym: "down-regulation of defense response to bacterium" EXACT [GOC:TermGenie]
synonym: "downregulation of antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "downregulation of defence response to bacteria" EXACT [GOC:TermGenie]
synonym: "downregulation of defence response to bacterium" EXACT [GOC:TermGenie]
synonym: "downregulation of defense response to bacteria" EXACT [GOC:TermGenie]
synonym: "downregulation of defense response to bacterium" EXACT [GOC:TermGenie]
synonym: "inhibition of antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "inhibition of defence response to bacteria" EXACT [GOC:TermGenie]
synonym: "inhibition of defence response to bacterium" EXACT [GOC:TermGenie]
synonym: "inhibition of defense response to bacteria" EXACT [GOC:TermGenie]
synonym: "inhibition of defense response to bacterium" NARROW [GOC:TermGenie]
synonym: "negative regulation of antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of defence response to bacteria" EXACT [GOC:TermGenie]
synonym: "negative regulation of defence response to bacterium" EXACT [GOC:TermGenie]
synonym: "negative regulation of defense response to bacteria" EXACT [GOC:TermGenie]
is_a: GO:0002832 ! negative regulation of response to biotic stimulus
is_a: GO:0031348 ! negative regulation of defense response
is_a: GO:0032102 ! negative regulation of response to external stimulus
is_a: GO:0043901 ! negative regulation of multi-organism process
is_a: GO:1900424 ! regulation of defense response to bacterium
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042742 ! defense response to bacterium
relationship: negatively_regulates GO:0042742 ! defense response to bacterium
created_by: dhl
creation_date: 2012-04-24T10:12:54Z

[Term]
id: GO:1900426
name: positive regulation of defense response to bacterium
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of defense response to bacterium." [GOC:TermGenie, PMID:22346749]
synonym: "activation of antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "activation of defence response to bacteria" EXACT [GOC:TermGenie]
synonym: "activation of defence response to bacterium" EXACT [GOC:TermGenie]
synonym: "activation of defense response to bacteria" EXACT [GOC:TermGenie]
synonym: "activation of defense response to bacterium" NARROW [GOC:TermGenie]
synonym: "positive regulation of antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of defence response to bacteria" EXACT [GOC:TermGenie]
synonym: "positive regulation of defence response to bacterium" EXACT [GOC:TermGenie]
synonym: "positive regulation of defense response to bacteria" EXACT [GOC:TermGenie]
synonym: "up regulation of antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "up regulation of defence response to bacteria" EXACT [GOC:TermGenie]
synonym: "up regulation of defence response to bacterium" EXACT [GOC:TermGenie]
synonym: "up regulation of defense response to bacteria" EXACT [GOC:TermGenie]
synonym: "up regulation of defense response to bacterium" EXACT [GOC:TermGenie]
synonym: "up-regulation of antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of defence response to bacteria" EXACT [GOC:TermGenie]
synonym: "up-regulation of defence response to bacterium" EXACT [GOC:TermGenie]
synonym: "up-regulation of defense response to bacteria" EXACT [GOC:TermGenie]
synonym: "up-regulation of defense response to bacterium" EXACT [GOC:TermGenie]
synonym: "upregulation of antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "upregulation of defence response to bacteria" EXACT [GOC:TermGenie]
synonym: "upregulation of defence response to bacterium" EXACT [GOC:TermGenie]
synonym: "upregulation of defense response to bacteria" EXACT [GOC:TermGenie]
synonym: "upregulation of defense response to bacterium" EXACT [GOC:TermGenie]
is_a: GO:0002833 ! positive regulation of response to biotic stimulus
is_a: GO:0031349 ! positive regulation of defense response
is_a: GO:0032103 ! positive regulation of response to external stimulus
is_a: GO:0043902 ! positive regulation of multi-organism process
is_a: GO:1900424 ! regulation of defense response to bacterium
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042742 ! defense response to bacterium
relationship: positively_regulates GO:0042742 ! defense response to bacterium
created_by: dhl
creation_date: 2012-04-24T10:13:13Z

[Term]
id: GO:1900427
name: regulation of cellular response to oxidative stress by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A regulation of transcription from RNA polymerase II promoter that results in regulation of cellular response to oxidative stress." [GOC:mah, GOC:TermGenie, PMID:10348908]
synonym: "regulation of adaptive response to oxidative stress by regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:1900407 ! regulation of cellular response to oxidative stress
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: regulates GO:0100038 ! regulation of cellular response to oxidative stress by transcription from RNA polymerase II promoter
relationship: regulates GO:0100038 ! regulation of cellular response to oxidative stress by transcription from RNA polymerase II promoter
created_by: mah
creation_date: 2012-04-25T09:11:41Z

[Term]
id: GO:1900428
name: regulation of filamentous growth of a population of unicellular organisms
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of filamentous growth of a population of unicellular organisms." [GOC:di, GOC:TermGenie]
is_a: GO:0010570 ! regulation of filamentous growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044182 ! filamentous growth of a population of unicellular organisms
relationship: regulates GO:0044182 ! filamentous growth of a population of unicellular organisms
created_by: di
creation_date: 2012-04-25T05:53:33Z

[Term]
id: GO:1900429
name: negative regulation of filamentous growth of a population of unicellular organisms
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of filamentous growth of a population of unicellular organisms." [GOC:di, GOC:TermGenie]
synonym: "down regulation of filamentous growth of a population of unicellular organisms" EXACT [GOC:TermGenie]
synonym: "down-regulation of filamentous growth of a population of unicellular organisms" EXACT [GOC:TermGenie]
synonym: "downregulation of filamentous growth of a population of unicellular organisms" EXACT [GOC:TermGenie]
synonym: "inhibition of filamentous growth of a population of unicellular organisms" NARROW [GOC:TermGenie]
is_a: GO:0060258 ! negative regulation of filamentous growth
is_a: GO:1900428 ! regulation of filamentous growth of a population of unicellular organisms
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044182 ! filamentous growth of a population of unicellular organisms
relationship: negatively_regulates GO:0044182 ! filamentous growth of a population of unicellular organisms
created_by: di
creation_date: 2012-04-25T05:53:43Z

[Term]
id: GO:1900430
name: positive regulation of filamentous growth of a population of unicellular organisms
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms." [GOC:di, GOC:TermGenie]
synonym: "activation of filamentous growth of a population of unicellular organisms" NARROW [GOC:TermGenie]
synonym: "up regulation of filamentous growth of a population of unicellular organisms" EXACT [GOC:TermGenie]
synonym: "up-regulation of filamentous growth of a population of unicellular organisms" EXACT [GOC:TermGenie]
synonym: "upregulation of filamentous growth of a population of unicellular organisms" EXACT [GOC:TermGenie]
is_a: GO:0090033 ! positive regulation of filamentous growth
is_a: GO:1900428 ! regulation of filamentous growth of a population of unicellular organisms
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044182 ! filamentous growth of a population of unicellular organisms
relationship: positively_regulates GO:0044182 ! filamentous growth of a population of unicellular organisms
created_by: di
creation_date: 2012-04-25T05:53:52Z

[Term]
id: GO:1900431
name: regulation of filamentous growth of a population of unicellular organisms in response to heat
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to heat." [GOC:di, GOC:TermGenie]
is_a: GO:0080134 ! regulation of response to stress
is_a: GO:1900428 ! regulation of filamentous growth of a population of unicellular organisms
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0036168 ! filamentous growth of a population of unicellular organisms in response to heat
relationship: regulates GO:0036168 ! filamentous growth of a population of unicellular organisms in response to heat
created_by: di
creation_date: 2012-04-25T05:54:05Z

[Term]
id: GO:1900432
name: negative regulation of filamentous growth of a population of unicellular organisms in response to heat
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to heat." [GOC:di, GOC:TermGenie]
synonym: "down regulation of filamentous growth of a population of unicellular organisms in response to heat" EXACT [GOC:TermGenie]
synonym: "down-regulation of filamentous growth of a population of unicellular organisms in response to heat" EXACT [GOC:TermGenie]
synonym: "downregulation of filamentous growth of a population of unicellular organisms in response to heat" EXACT [GOC:TermGenie]
synonym: "inhibition of filamentous growth of a population of unicellular organisms in response to heat" NARROW [GOC:TermGenie]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1900429 ! negative regulation of filamentous growth of a population of unicellular organisms
is_a: GO:1900431 ! regulation of filamentous growth of a population of unicellular organisms in response to heat
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0036168 ! filamentous growth of a population of unicellular organisms in response to heat
relationship: negatively_regulates GO:0036168 ! filamentous growth of a population of unicellular organisms in response to heat
created_by: di
creation_date: 2012-04-25T05:54:15Z

[Term]
id: GO:1900433
name: positive regulation of filamentous growth of a population of unicellular organisms in response to heat
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to heat." [GOC:di, GOC:TermGenie]
synonym: "activation of filamentous growth of a population of unicellular organisms in response to heat" NARROW [GOC:TermGenie]
synonym: "up regulation of filamentous growth of a population of unicellular organisms in response to heat" EXACT [GOC:TermGenie]
synonym: "up-regulation of filamentous growth of a population of unicellular organisms in response to heat" EXACT [GOC:TermGenie]
synonym: "upregulation of filamentous growth of a population of unicellular organisms in response to heat" EXACT [GOC:TermGenie]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1900430 ! positive regulation of filamentous growth of a population of unicellular organisms
is_a: GO:1900431 ! regulation of filamentous growth of a population of unicellular organisms in response to heat
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0036168 ! filamentous growth of a population of unicellular organisms in response to heat
relationship: positively_regulates GO:0036168 ! filamentous growth of a population of unicellular organisms in response to heat
created_by: di
creation_date: 2012-04-25T05:54:23Z

[Term]
id: GO:1900434
name: regulation of filamentous growth of a population of unicellular organisms in response to starvation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to starvation." [GOC:di, GOC:TermGenie]
is_a: GO:0032107 ! regulation of response to nutrient levels
is_a: GO:0080134 ! regulation of response to stress
is_a: GO:1900428 ! regulation of filamentous growth of a population of unicellular organisms
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0036170 ! filamentous growth of a population of unicellular organisms in response to starvation
relationship: regulates GO:0036170 ! filamentous growth of a population of unicellular organisms in response to starvation
created_by: di
creation_date: 2012-04-25T05:54:46Z

[Term]
id: GO:1900435
name: negative regulation of filamentous growth of a population of unicellular organisms in response to starvation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to starvation." [GOC:di, GOC:TermGenie]
synonym: "down regulation of filamentous growth of a population of unicellular organisms in response to starvation" EXACT [GOC:TermGenie]
synonym: "down-regulation of filamentous growth of a population of unicellular organisms in response to starvation" EXACT [GOC:TermGenie]
synonym: "downregulation of filamentous growth of a population of unicellular organisms in response to starvation" EXACT [GOC:TermGenie]
synonym: "inhibition of filamentous growth of a population of unicellular organisms in response to starvation" NARROW [GOC:TermGenie]
is_a: GO:0032108 ! negative regulation of response to nutrient levels
is_a: GO:1900429 ! negative regulation of filamentous growth of a population of unicellular organisms
is_a: GO:1900434 ! regulation of filamentous growth of a population of unicellular organisms in response to starvation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0036170 ! filamentous growth of a population of unicellular organisms in response to starvation
relationship: negatively_regulates GO:0036170 ! filamentous growth of a population of unicellular organisms in response to starvation
created_by: di
creation_date: 2012-04-25T05:54:56Z

[Term]
id: GO:1900436
name: positive regulation of filamentous growth of a population of unicellular organisms in response to starvation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to starvation." [GOC:di, GOC:TermGenie]
synonym: "activation of filamentous growth of a population of unicellular organisms in response to starvation" NARROW [GOC:TermGenie]
synonym: "up regulation of filamentous growth of a population of unicellular organisms in response to starvation" EXACT [GOC:TermGenie]
synonym: "up-regulation of filamentous growth of a population of unicellular organisms in response to starvation" EXACT [GOC:TermGenie]
synonym: "upregulation of filamentous growth of a population of unicellular organisms in response to starvation" EXACT [GOC:TermGenie]
is_a: GO:0032109 ! positive regulation of response to nutrient levels
is_a: GO:1900430 ! positive regulation of filamentous growth of a population of unicellular organisms
is_a: GO:1900434 ! regulation of filamentous growth of a population of unicellular organisms in response to starvation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0036170 ! filamentous growth of a population of unicellular organisms in response to starvation
relationship: positively_regulates GO:0036170 ! filamentous growth of a population of unicellular organisms in response to starvation
created_by: di
creation_date: 2012-04-25T05:55:05Z

[Term]
id: GO:1900437
name: regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to chemical stimulus." [GOC:di, GOC:TermGenie]
is_a: GO:0048583 ! regulation of response to stimulus
is_a: GO:1900428 ! regulation of filamentous growth of a population of unicellular organisms
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0036171 ! filamentous growth of a population of unicellular organisms in response to chemical stimulus
relationship: regulates GO:0036171 ! filamentous growth of a population of unicellular organisms in response to chemical stimulus
created_by: di
creation_date: 2012-04-25T05:55:17Z

[Term]
id: GO:1900438
name: negative regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to chemical stimulus." [GOC:di, GOC:TermGenie]
synonym: "down regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus" EXACT [GOC:TermGenie]
synonym: "down-regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus" EXACT [GOC:TermGenie]
synonym: "downregulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus" EXACT [GOC:TermGenie]
synonym: "inhibition of filamentous growth of a population of unicellular organisms in response to chemical stimulus" NARROW [GOC:TermGenie]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1900429 ! negative regulation of filamentous growth of a population of unicellular organisms
is_a: GO:1900437 ! regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0036171 ! filamentous growth of a population of unicellular organisms in response to chemical stimulus
relationship: negatively_regulates GO:0036171 ! filamentous growth of a population of unicellular organisms in response to chemical stimulus
created_by: di
creation_date: 2012-04-25T05:55:26Z

[Term]
id: GO:1900439
name: positive regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to chemical stimulus." [GOC:di, GOC:TermGenie]
synonym: "activation of filamentous growth of a population of unicellular organisms in response to chemical stimulus" NARROW [GOC:TermGenie]
synonym: "up regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus" EXACT [GOC:TermGenie]
synonym: "up-regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus" EXACT [GOC:TermGenie]
synonym: "upregulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus" EXACT [GOC:TermGenie]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1900430 ! positive regulation of filamentous growth of a population of unicellular organisms
is_a: GO:1900437 ! regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0036171 ! filamentous growth of a population of unicellular organisms in response to chemical stimulus
relationship: positively_regulates GO:0036171 ! filamentous growth of a population of unicellular organisms in response to chemical stimulus
created_by: di
creation_date: 2012-04-25T05:55:35Z

[Term]
id: GO:1900440
name: regulation of filamentous growth of a population of unicellular organisms in response to neutral pH
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to neutral pH." [GOC:di, GOC:TermGenie]
is_a: GO:1900741 ! regulation of filamentous growth of a population of unicellular organisms in response to pH
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0036178 ! filamentous growth of a population of unicellular organisms in response to neutral pH
relationship: regulates GO:0036178 ! filamentous growth of a population of unicellular organisms in response to neutral pH
created_by: di
creation_date: 2012-04-25T05:55:48Z

[Term]
id: GO:1900441
name: negative regulation of filamentous growth of a population of unicellular organisms in response to neutral pH
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to neutral pH." [GOC:di, GOC:TermGenie]
synonym: "down regulation of filamentous growth of a population of unicellular organisms in response to neutral pH" EXACT [GOC:TermGenie]
synonym: "down-regulation of filamentous growth of a population of unicellular organisms in response to neutral pH" EXACT [GOC:TermGenie]
synonym: "downregulation of filamentous growth of a population of unicellular organisms in response to neutral pH" EXACT [GOC:TermGenie]
synonym: "inhibition of filamentous growth of a population of unicellular organisms in response to neutral pH" NARROW [GOC:TermGenie]
is_a: GO:1900440 ! regulation of filamentous growth of a population of unicellular organisms in response to neutral pH
is_a: GO:1900742 ! negative regulation of filamentous growth of a population of unicellular organisms in response to pH
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0036178 ! filamentous growth of a population of unicellular organisms in response to neutral pH
relationship: negatively_regulates GO:0036178 ! filamentous growth of a population of unicellular organisms in response to neutral pH
created_by: di
creation_date: 2012-04-25T05:55:57Z

[Term]
id: GO:1900442
name: positive regulation of filamentous growth of a population of unicellular organisms in response to neutral pH
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to neutral pH." [GOC:di, GOC:TermGenie]
synonym: "activation of filamentous growth of a population of unicellular organisms in response to neutral pH" NARROW [GOC:TermGenie]
synonym: "up regulation of filamentous growth of a population of unicellular organisms in response to neutral pH" EXACT [GOC:TermGenie]
synonym: "up-regulation of filamentous growth of a population of unicellular organisms in response to neutral pH" EXACT [GOC:TermGenie]
synonym: "upregulation of filamentous growth of a population of unicellular organisms in response to neutral pH" EXACT [GOC:TermGenie]
is_a: GO:1900440 ! regulation of filamentous growth of a population of unicellular organisms in response to neutral pH
is_a: GO:1900743 ! positive regulation of filamentous growth of a population of unicellular organisms in response to pH
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0036178 ! filamentous growth of a population of unicellular organisms in response to neutral pH
relationship: positively_regulates GO:0036178 ! filamentous growth of a population of unicellular organisms in response to neutral pH
created_by: di
creation_date: 2012-04-25T05:56:06Z

[Term]
id: GO:1900443
name: regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to biotic stimulus." [GOC:di, GOC:TermGenie]
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:1900428 ! regulation of filamentous growth of a population of unicellular organisms
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0036180 ! filamentous growth of a population of unicellular organisms in response to biotic stimulus
relationship: regulates GO:0036180 ! filamentous growth of a population of unicellular organisms in response to biotic stimulus
created_by: di
creation_date: 2012-04-25T05:56:18Z

[Term]
id: GO:1900444
name: negative regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to biotic stimulus." [GOC:di, GOC:TermGenie]
synonym: "down regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus" EXACT [GOC:TermGenie]
synonym: "down-regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus" EXACT [GOC:TermGenie]
synonym: "downregulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus" EXACT [GOC:TermGenie]
synonym: "inhibition of filamentous growth of a population of unicellular organisms in response to biotic stimulus" NARROW [GOC:TermGenie]
is_a: GO:0002832 ! negative regulation of response to biotic stimulus
is_a: GO:1900429 ! negative regulation of filamentous growth of a population of unicellular organisms
is_a: GO:1900443 ! regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0036180 ! filamentous growth of a population of unicellular organisms in response to biotic stimulus
relationship: negatively_regulates GO:0036180 ! filamentous growth of a population of unicellular organisms in response to biotic stimulus
created_by: di
creation_date: 2012-04-25T05:56:27Z

[Term]
id: GO:1900445
name: positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to biotic stimulus." [GOC:di, GOC:TermGenie]
synonym: "activation of filamentous growth of a population of unicellular organisms in response to biotic stimulus" NARROW [GOC:TermGenie]
synonym: "up regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus" EXACT [GOC:TermGenie]
synonym: "up-regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus" EXACT [GOC:TermGenie]
synonym: "upregulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus" EXACT [GOC:TermGenie]
is_a: GO:0002833 ! positive regulation of response to biotic stimulus
is_a: GO:1900430 ! positive regulation of filamentous growth of a population of unicellular organisms
is_a: GO:1900443 ! regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0036180 ! filamentous growth of a population of unicellular organisms in response to biotic stimulus
relationship: positively_regulates GO:0036180 ! filamentous growth of a population of unicellular organisms in response to biotic stimulus
created_by: di
creation_date: 2012-04-25T05:56:35Z

[Term]
id: GO:1900446
name: negative regulation of tRNA transcription from RNA polymerase III promoter
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tRNA transcription from RNA polymerase III promoter." [GOC:sart, GOC:TermGenie]
synonym: "down regulation of tRNA transcription from Pol III promoter" EXACT [GOC:TermGenie]
synonym: "down regulation of tRNA transcription from RNA polymerase III promoter" EXACT [GOC:TermGenie]
synonym: "down-regulation of tRNA transcription from Pol III promoter" EXACT [GOC:TermGenie]
synonym: "down-regulation of tRNA transcription from RNA polymerase III promoter" EXACT [GOC:TermGenie]
synonym: "downregulation of tRNA transcription from Pol III promoter" EXACT [GOC:TermGenie]
synonym: "downregulation of tRNA transcription from RNA polymerase III promoter" EXACT [GOC:TermGenie]
synonym: "inhibition of tRNA transcription from Pol III promoter" EXACT [GOC:TermGenie]
synonym: "inhibition of tRNA transcription from RNA polymerase III promoter" NARROW [GOC:TermGenie]
synonym: "negative regulation of tRNA transcription from Pol III promoter" EXACT [GOC:TermGenie]
is_a: GO:0016480 ! negative regulation of transcription from RNA polymerase III promoter
is_a: GO:1903327 ! negative regulation of tRNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042797 ! tRNA transcription from RNA polymerase III promoter
relationship: negatively_regulates GO:0042797 ! tRNA transcription from RNA polymerase III promoter
created_by: sart
creation_date: 2012-04-26T05:28:34Z

[Term]
id: GO:1900447
name: regulation of cell morphogenesis involved in phenotypic switching
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell morphogenesis contributing a phenotypic switch. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells, such as the opaque cells of C. albicans, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:di, GOC:TermGenie]
synonym: "negative regulation of cell shape and cell size of phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "negative regulation of cell shape and cell size of phenotypic switching" RELATED [GOC:TermGenie]
synonym: "positive regulation of cell shape and cell size of phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "positive regulation of cell shape and cell size of phenotypic switching" RELATED [GOC:TermGenie]
synonym: "regulation of cell morphogenesis of phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "regulation of cell morphogenesis of phenotypic switching" EXACT [GOC:TermGenie]
synonym: "regulation of cell shape and cell size of phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "regulation of cell shape and cell size of phenotypic switching" RELATED [GOC:TermGenie]
is_a: GO:0022604 ! regulation of cell morphogenesis
intersection_of: GO:0022604 ! regulation of cell morphogenesis
intersection_of: part_of GO:0036166 ! phenotypic switching
relationship: part_of GO:0036166 ! phenotypic switching
created_by: di
creation_date: 2012-04-27T02:43:32Z

[Term]
id: GO:1900448
name: regulation of pyrimidine nucleotide biosynthetic process by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pyrimidine nucleotide biosynthesis by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:TermGenie]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:1900397 ! regulation of pyrimidine nucleotide biosynthetic process
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: regulates GO:0100039 ! regulation of pyrimidine nucleotide biosynthetic process by transcription from RNA polymerase II promoter
relationship: regulates GO:0100039 ! regulation of pyrimidine nucleotide biosynthetic process by transcription from RNA polymerase II promoter
created_by: jh
creation_date: 2012-04-27T02:57:38Z

[Term]
id: GO:1900449
name: regulation of glutamate receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glutamate receptor signaling pathway." [GOC:BHF, GOC:TermGenie]
synonym: "regulation of glutamate signaling pathway" EXACT [GOC:TermGenie]
synonym: "regulation of glutamate signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0009966 ! regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007215 ! glutamate receptor signaling pathway
relationship: regulates GO:0007215 ! glutamate receptor signaling pathway
created_by: rl
creation_date: 2012-04-27T03:45:43Z

[Term]
id: GO:1900450
name: negative regulation of glutamate receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glutamate receptor signaling pathway." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of glutamate receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of glutamate signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of glutamate signalling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of glutamate receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of glutamate signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of glutamate signalling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of glutamate receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of glutamate signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of glutamate signalling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of glutamate receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of glutamate signaling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of glutamate signalling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of glutamate signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of glutamate signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:1900449 ! regulation of glutamate receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007215 ! glutamate receptor signaling pathway
relationship: negatively_regulates GO:0007215 ! glutamate receptor signaling pathway
created_by: rl
creation_date: 2012-04-27T03:45:53Z

[Term]
id: GO:1900451
name: positive regulation of glutamate receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glutamate receptor signaling pathway." [GOC:BHF, GOC:TermGenie]
synonym: "activation of glutamate receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of glutamate signaling pathway" EXACT [GOC:TermGenie]
synonym: "activation of glutamate signalling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of glutamate signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of glutamate signalling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of glutamate receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of glutamate signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of glutamate signalling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of glutamate receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of glutamate signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of glutamate signalling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of glutamate receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of glutamate signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of glutamate signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:1900449 ! regulation of glutamate receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007215 ! glutamate receptor signaling pathway
relationship: positively_regulates GO:0007215 ! glutamate receptor signaling pathway
created_by: rl
creation_date: 2012-04-27T03:46:03Z

[Term]
id: GO:1900452
name: regulation of long term synaptic depression
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of long term synaptic depression." [GOC:BHF, GOC:TermGenie]
synonym: "regulation of long term depression" BROAD [GOC:TermGenie]
synonym: "regulation of LTD" RELATED [GOC:TermGenie]
is_a: GO:0048167 ! regulation of synaptic plasticity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060292 ! long term synaptic depression
relationship: regulates GO:0060292 ! long term synaptic depression
created_by: rl
creation_date: 2012-04-27T03:54:58Z

[Term]
id: GO:1900453
name: negative regulation of long term synaptic depression
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of long term synaptic depression." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of long term depression" BROAD [GOC:TermGenie]
synonym: "down regulation of long term synaptic depression" EXACT [GOC:TermGenie]
synonym: "down regulation of LTD" RELATED [GOC:TermGenie]
synonym: "down-regulation of long term depression" BROAD [GOC:TermGenie]
synonym: "down-regulation of long term synaptic depression" EXACT [GOC:TermGenie]
synonym: "down-regulation of LTD" RELATED [GOC:TermGenie]
synonym: "downregulation of long term depression" BROAD [GOC:TermGenie]
synonym: "downregulation of long term synaptic depression" EXACT [GOC:TermGenie]
synonym: "downregulation of LTD" RELATED [GOC:TermGenie]
synonym: "inhibition of long term depression" BROAD [GOC:TermGenie]
synonym: "inhibition of long term synaptic depression" NARROW [GOC:TermGenie]
synonym: "inhibition of LTD" RELATED [GOC:TermGenie]
synonym: "negative regulation of long term depression" BROAD [GOC:TermGenie]
synonym: "negative regulation of LTD" RELATED [GOC:TermGenie]
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0050806 ! positive regulation of synaptic transmission
is_a: GO:1900452 ! regulation of long term synaptic depression
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060292 ! long term synaptic depression
relationship: negatively_regulates GO:0060292 ! long term synaptic depression
created_by: rl
creation_date: 2012-04-27T03:55:14Z

[Term]
id: GO:1900454
name: positive regulation of long term synaptic depression
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of long term synaptic depression." [GOC:BHF, GOC:TermGenie]
synonym: "activation of long term depression" BROAD [GOC:TermGenie]
synonym: "activation of long term synaptic depression" NARROW [GOC:TermGenie]
synonym: "activation of LTD" RELATED [GOC:TermGenie]
synonym: "positive regulation of long term depression" BROAD [GOC:TermGenie]
synonym: "positive regulation of LTD" RELATED [GOC:TermGenie]
synonym: "up regulation of long term depression" BROAD [GOC:TermGenie]
synonym: "up regulation of long term synaptic depression" EXACT [GOC:TermGenie]
synonym: "up regulation of LTD" RELATED [GOC:TermGenie]
synonym: "up-regulation of long term depression" BROAD [GOC:TermGenie]
synonym: "up-regulation of long term synaptic depression" EXACT [GOC:TermGenie]
synonym: "up-regulation of LTD" RELATED [GOC:TermGenie]
synonym: "upregulation of long term depression" BROAD [GOC:TermGenie]
synonym: "upregulation of long term synaptic depression" EXACT [GOC:TermGenie]
synonym: "upregulation of LTD" RELATED [GOC:TermGenie]
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:1900452 ! regulation of long term synaptic depression
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060292 ! long term synaptic depression
relationship: positively_regulates GO:0060292 ! long term synaptic depression
created_by: rl
creation_date: 2012-04-27T03:55:23Z

[Term]
id: GO:1900455
name: regulation of flocculation via cell wall protein-carbohydrate interaction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of flocculation via cell wall protein-carbohydrate interaction." [GOC:dgf, GOC:TermGenie, PMID:10591965, PMID:15466424, PMID:16568252]
is_a: GO:0060256 ! regulation of flocculation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000501 ! flocculation via cell wall protein-carbohydrate interaction
relationship: regulates GO:0000501 ! flocculation via cell wall protein-carbohydrate interaction
created_by: dianna.fisk
creation_date: 2012-05-01T05:03:32Z

[Term]
id: GO:1900456
name: obsolete regulation of invasive growth in response to glucose limitation by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of invasive growth in response to glucose limitation by modulating the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:10373537, PMID:10591965, PMID:12024013, PMID:15466424, PMID:16568252, PMID:8710886, PMID:9811878, PMID:9987114]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "regulation of colony morphology by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of invasive growth in response to glucose limitation by regulation of transcription from RNA polymerase II promoter" EXACT []
is_obsolete: true
created_by: dianna.fisk
creation_date: 2012-05-01T05:42:03Z

[Term]
id: GO:1900457
name: regulation of brassinosteroid mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of brassinosteroid mediated signaling pathway." [GOC:TermGenie, PMID:21855796]
synonym: "regulation of brassinosteroid mediated signalling" EXACT [GOC:TermGenie]
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:1901419 ! regulation of response to alcohol
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009742 ! brassinosteroid mediated signaling pathway
relationship: regulates GO:0009742 ! brassinosteroid mediated signaling pathway
created_by: dhl
creation_date: 2012-05-01T06:12:04Z

[Term]
id: GO:1900458
name: negative regulation of brassinosteroid mediated signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of brassinosteroid mediated signaling pathway." [GOC:TermGenie, PMID:21855796]
synonym: "down regulation of brassinosteroid mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of brassinosteroid mediated signalling" EXACT [GOC:TermGenie]
synonym: "down-regulation of brassinosteroid mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of brassinosteroid mediated signalling" EXACT [GOC:TermGenie]
synonym: "downregulation of brassinosteroid mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of brassinosteroid mediated signalling" EXACT [GOC:TermGenie]
synonym: "inhibition of brassinosteroid mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of brassinosteroid mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of brassinosteroid mediated signalling" EXACT [GOC:TermGenie]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:1900457 ! regulation of brassinosteroid mediated signaling pathway
is_a: GO:1901420 ! negative regulation of response to alcohol
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009742 ! brassinosteroid mediated signaling pathway
relationship: negatively_regulates GO:0009742 ! brassinosteroid mediated signaling pathway
created_by: dhl
creation_date: 2012-05-01T06:12:13Z

[Term]
id: GO:1900459
name: positive regulation of brassinosteroid mediated signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of brassinosteroid mediated signaling pathway." [GOC:TermGenie, PMID:21855796]
synonym: "activation of brassinosteroid mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of brassinosteroid mediated signalling" EXACT [GOC:TermGenie]
synonym: "positive regulation of brassinosteroid mediated signalling" EXACT [GOC:TermGenie]
synonym: "up regulation of brassinosteroid mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of brassinosteroid mediated signalling" EXACT [GOC:TermGenie]
synonym: "up-regulation of brassinosteroid mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of brassinosteroid mediated signalling" EXACT [GOC:TermGenie]
synonym: "upregulation of brassinosteroid mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of brassinosteroid mediated signalling" EXACT [GOC:TermGenie]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:1900457 ! regulation of brassinosteroid mediated signaling pathway
is_a: GO:1901421 ! positive regulation of response to alcohol
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009742 ! brassinosteroid mediated signaling pathway
relationship: positively_regulates GO:0009742 ! brassinosteroid mediated signaling pathway
created_by: dhl
creation_date: 2012-05-01T06:12:23Z

[Term]
id: GO:1900460
name: negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of invasive growth in response to glucose limitation by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:12024013, PMID:15466424, PMID:9811878]
synonym: "negative regulation of colony morphology by negative regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
is_a: GO:2000218 ! negative regulation of invasive growth in response to glucose limitation
intersection_of: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
intersection_of: negatively_regulates GO:0001403 ! invasive growth in response to glucose limitation
relationship: negatively_regulates GO:0001403 ! invasive growth in response to glucose limitation
created_by: dianna.fisk
creation_date: 2012-05-01T06:09:17Z

[Term]
id: GO:1900461
name: positive regulation of pseudohyphal growth by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pseudohyphal growth by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:11046133, PMID:8710886, PMID:9987114]
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
is_a: GO:2000222 ! positive regulation of pseudohyphal growth
intersection_of: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
intersection_of: positively_regulates GO:0007124 ! pseudohyphal growth
relationship: positively_regulates GO:0007124 ! pseudohyphal growth
created_by: dianna.fisk
creation_date: 2012-05-01T07:01:40Z

[Term]
id: GO:1900462
name: negative regulation of pseudohyphal growth by negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pseudohyphal growth by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of pseudohyphal growth by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:12024012, PMID:9811878]
is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
is_a: GO:2000221 ! negative regulation of pseudohyphal growth
intersection_of: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
intersection_of: negatively_regulates GO:0007124 ! pseudohyphal growth
relationship: negatively_regulates GO:0007124 ! pseudohyphal growth
created_by: dianna.fisk
creation_date: 2012-05-01T07:01:54Z

[Term]
id: GO:1900463
name: negative regulation of cellular response to alkaline pH by negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular response to alkalinity by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:12509465, PMID:17023428]
synonym: "negative regulation of cellular response to alkalinity by negative regulation of transcription from RNA polymerase II promoter" BROAD []
synonym: "negative regulation of cellular response to basic pH by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1900068 ! negative regulation of cellular response to alkaline pH
intersection_of: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
intersection_of: negatively_regulates GO:0071469 ! cellular response to alkaline pH
relationship: negatively_regulates GO:0071469 ! cellular response to alkaline pH
created_by: dianna.fisk
creation_date: 2012-05-01T07:22:50Z

[Term]
id: GO:1900464
name: negative regulation of cellular hyperosmotic salinity response by negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular hyperosmotic salinity response by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:16278455]
synonym: "negative regulation of cellular response to hyperosmotic salt stress by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:1900070 ! negative regulation of cellular hyperosmotic salinity response
intersection_of: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
intersection_of: negatively_regulates GO:0071475 ! cellular hyperosmotic salinity response
relationship: negatively_regulates GO:0071475 ! cellular hyperosmotic salinity response
created_by: dianna.fisk
creation_date: 2012-05-01T07:29:19Z

[Term]
id: GO:1900465
name: negative regulation of arginine catabolic process by negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular arginine catabolic process by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:19233144, PMID:8455631]
synonym: "negative regulation of arginine breakdown by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of arginine catabolism by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of arginine degradation by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_a: GO:0033243 ! positive regulation of cellular amine catabolic process
is_a: GO:0045764 ! positive regulation of cellular amino acid metabolic process
is_a: GO:0072365 ! regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter
is_a: GO:1900082 ! negative regulation of arginine catabolic process
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: negatively_regulates GO:0100045 ! negative regulation of arginine catabolic process by transcription from RNA polymerase II promoter
relationship: negatively_regulates GO:0100045 ! negative regulation of arginine catabolic process by transcription from RNA polymerase II promoter
created_by: dianna.fisk
creation_date: 2012-05-01T07:38:01Z

[Term]
id: GO:1900466
name: positive regulation of arginine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of arginine biosynthetic process by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:19233144, PMID:8455631]
synonym: "activation of arginine anabolism by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "activation of arginine biosynthesis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "activation of arginine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "activation of arginine formation by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "activation of arginine synthesis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "positive regulation of arginine anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of arginine biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of arginine formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of arginine synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of arginine anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of arginine biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of arginine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of arginine formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of arginine synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of arginine anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of arginine biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of arginine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of arginine formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of arginine synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of arginine anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of arginine biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of arginine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of arginine formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of arginine synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_a: GO:0072366 ! regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter
is_a: GO:1900080 ! positive regulation of arginine biosynthetic process
intersection_of: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
intersection_of: positively_regulates GO:0006526 ! arginine biosynthetic process
relationship: positively_regulates GO:0006526 ! arginine biosynthetic process
created_by: dianna.fisk
creation_date: 2012-05-01T07:38:14Z

[Term]
id: GO:1900467
name: obsolete regulation of cellular potassium ion homeostasis
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of cellular potassium ion homeostasis." [GOC:dgf, GOC:TermGenie, PMID:20412803]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "regulation of cellular potassium ion homeostasis" EXACT []
is_obsolete: true
created_by: dianna.fisk
creation_date: 2012-05-01T07:48:07Z

[Term]
id: GO:1900468
name: regulation of phosphatidylserine biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phosphatidylserine biosynthetic process." [GOC:dgf, GOC:TermGenie, PMID:8056324, PMID:8614637]
synonym: "regulation of phosphatidylserine anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of phosphatidylserine biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of phosphatidylserine formation" EXACT [GOC:TermGenie]
synonym: "regulation of phosphatidylserine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0071071 ! regulation of phospholipid biosynthetic process
is_a: GO:2000282 ! regulation of cellular amino acid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006659 ! phosphatidylserine biosynthetic process
relationship: regulates GO:0006659 ! phosphatidylserine biosynthetic process
created_by: dianna.fisk
creation_date: 2012-05-01T08:01:01Z

[Term]
id: GO:1900469
name: negative regulation of phosphatidylserine biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylserine biosynthetic process." [GOC:dgf, GOC:TermGenie, PMID:8056324, PMID:8614637]
synonym: "down regulation of phosphatidylserine anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphatidylserine biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphatidylserine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphatidylserine formation" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphatidylserine synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphatidylserine anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphatidylserine biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphatidylserine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphatidylserine formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphatidylserine synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphatidylserine anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphatidylserine biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphatidylserine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphatidylserine formation" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphatidylserine synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of phosphatidylserine anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of phosphatidylserine biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of phosphatidylserine biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of phosphatidylserine formation" EXACT [GOC:TermGenie]
synonym: "inhibition of phosphatidylserine synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphatidylserine anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphatidylserine biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphatidylserine formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphatidylserine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0071072 ! negative regulation of phospholipid biosynthetic process
is_a: GO:1900468 ! regulation of phosphatidylserine biosynthetic process
is_a: GO:2000283 ! negative regulation of cellular amino acid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006659 ! phosphatidylserine biosynthetic process
relationship: negatively_regulates GO:0006659 ! phosphatidylserine biosynthetic process
created_by: dianna.fisk
creation_date: 2012-05-01T08:01:11Z

[Term]
id: GO:1900470
name: positive regulation of phosphatidylserine biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phosphatidylserine biosynthetic process." [GOC:dgf, GOC:TermGenie, PMID:8056324, PMID:8614637]
synonym: "activation of phosphatidylserine anabolism" EXACT [GOC:TermGenie]
synonym: "activation of phosphatidylserine biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of phosphatidylserine biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of phosphatidylserine formation" EXACT [GOC:TermGenie]
synonym: "activation of phosphatidylserine synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphatidylserine anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphatidylserine biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphatidylserine formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphatidylserine synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphatidylserine anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphatidylserine biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphatidylserine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphatidylserine formation" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphatidylserine synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphatidylserine anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphatidylserine biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphatidylserine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphatidylserine formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphatidylserine synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphatidylserine anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphatidylserine biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphatidylserine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphatidylserine formation" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphatidylserine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0071073 ! positive regulation of phospholipid biosynthetic process
is_a: GO:1900468 ! regulation of phosphatidylserine biosynthetic process
is_a: GO:2000284 ! positive regulation of cellular amino acid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006659 ! phosphatidylserine biosynthetic process
relationship: positively_regulates GO:0006659 ! phosphatidylserine biosynthetic process
created_by: dianna.fisk
creation_date: 2012-05-01T08:01:19Z

[Term]
id: GO:1900471
name: negative regulation of inositol biosynthetic process by negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of inositol biosynthetic process by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:8056324, PMID:8614637]
synonym: "negative regulation of inositol anabolism by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of inositol biosynthesis by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of inositol formation by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of inositol synthesis by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of myo-inositol biosynthesis by negative regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "negative regulation of myo-inositol biosynthetic process by negative regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "negative regulation of vitamin Bh biosynthesis by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of vitamin Bh biosynthetic process by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
is_a: GO:0010678 ! negative regulation of cellular carbohydrate metabolic process by negative regulation of transcription, DNA-templated
is_a: GO:1900089 ! negative regulation of inositol biosynthetic process
is_a: GO:1900090 ! positive regulation of inositol biosynthetic process
is_a: GO:1900402 ! regulation of carbohydrate metabolic process by regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
intersection_of: negatively_regulates GO:0006021 ! inositol biosynthetic process
relationship: negatively_regulates GO:0006021 ! inositol biosynthetic process
created_by: dianna.fisk
creation_date: 2012-05-01T08:13:23Z

[Term]
id: GO:1900472
name: positive regulation of phosphatidylcholine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phosphatidylcholine biosynthetic process by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:8056324, PMID:8614637]
synonym: "positive regulation of phosphatidylcholine anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphatidylcholine biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphatidylcholine formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphatidylcholine synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_a: GO:1900413 ! positive regulation of phospholipid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter
is_a: GO:2001247 ! positive regulation of phosphatidylcholine biosynthetic process
intersection_of: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
intersection_of: positively_regulates GO:0006656 ! phosphatidylcholine biosynthetic process
relationship: positively_regulates GO:0006656 ! phosphatidylcholine biosynthetic process
created_by: dianna.fisk
creation_date: 2012-05-01T08:13:36Z

[Term]
id: GO:1900473
name: negative regulation of phosphatidylcholine biosynthetic process by negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of phosphatidylcholine biosynthetic process by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:8056324]
synonym: "negative regulation of phosphatidylcholine anabolism by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphatidylcholine biosynthesis by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphatidylcholine formation by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphatidylcholine synthesis by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
is_a: GO:2001246 ! negative regulation of phosphatidylcholine biosynthetic process
intersection_of: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
intersection_of: negatively_regulates GO:0006656 ! phosphatidylcholine biosynthetic process
relationship: negatively_regulates GO:0006656 ! phosphatidylcholine biosynthetic process
created_by: dianna.fisk
creation_date: 2012-05-01T08:13:51Z

[Term]
id: GO:1900474
name: negative regulation of mating type switching by negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mating type switching by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:8625408, PMID:8625409]
is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
is_a: GO:0031495 ! negative regulation of mating type switching
intersection_of: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
intersection_of: negatively_regulates GO:0007533 ! mating type switching
relationship: negatively_regulates GO:0007533 ! mating type switching
created_by: dianna.fisk
creation_date: 2012-05-01T08:33:18Z

[Term]
id: GO:1900475
name: positive regulation of meiosis by negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of meiosis by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:8618927]
synonym: "activation of meiosis by negative regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "stimulation of meiosis by negative regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "up regulation of meiosis by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of meiosis by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of meiosis by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
is_a: GO:0045836 ! positive regulation of meiotic nuclear division
is_a: GO:1900401 ! regulation of meiosis by regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: negatively_regulates GO:0100051 ! positive regulation of meiotic nuclear division by transcription from RNA polymerase II promoter
relationship: negatively_regulates GO:0100051 ! positive regulation of meiotic nuclear division by transcription from RNA polymerase II promoter
created_by: dianna.fisk
creation_date: 2012-05-01T08:39:58Z

[Term]
id: GO:1900476
name: positive regulation of meiosis by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of meiosis by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:8618927]
synonym: "activation of meiosis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "stimulation of meiosis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "up regulation of meiosis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of meiosis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of meiosis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_a: GO:0045836 ! positive regulation of meiotic nuclear division
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
is_a: GO:1900401 ! regulation of meiosis by regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: positively_regulates GO:0100051 ! positive regulation of meiotic nuclear division by transcription from RNA polymerase II promoter
relationship: positively_regulates GO:0100051 ! positive regulation of meiotic nuclear division by transcription from RNA polymerase II promoter
created_by: dianna.fisk
creation_date: 2012-05-01T08:40:11Z

[Term]
id: GO:1900477
name: negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of G1/S transition of mitotic cell cycle by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:19841732]
is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
is_a: GO:1900087 ! positive regulation of G1/S transition of mitotic cell cycle
is_a: GO:2000134 ! negative regulation of G1/S transition of mitotic cell cycle
intersection_of: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
intersection_of: negatively_regulates GO:0000082 ! G1/S transition of mitotic cell cycle
relationship: negatively_regulates GO:0000082 ! G1/S transition of mitotic cell cycle
created_by: dianna.fisk
creation_date: 2012-05-01T09:01:04Z

[Term]
id: GO:1900478
name: positive regulation of sulfate assimilation by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sulfate assimilation by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:7601277, PMID:7891681]
synonym: "activation of sulfate assimilation by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "activation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "activation of sulphate assimilation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "activation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "positive regulation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "positive regulation of sulphate assimilation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "up regulation of sulfate assimilation by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "up regulation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "up regulation of sulphate assimilation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "up-regulation of sulfate assimilation by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "up-regulation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "up-regulation of sulphate assimilation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "upregulation of sulfate assimilation by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "upregulation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "upregulation of sulphate assimilation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
is_a: GO:1900059 ! positive regulation of sulfate assimilation
intersection_of: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
intersection_of: positively_regulates GO:0000103 ! sulfate assimilation
relationship: positively_regulates GO:0000103 ! sulfate assimilation
created_by: dianna.fisk
creation_date: 2012-05-01T09:08:04Z

[Term]
id: GO:1900479
name: positive regulation of flocculation via cell wall protein-carbohydrate interaction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of flocculation via cell wall protein-carbohydrate interaction." [GOC:dgf, GOC:TermGenie, PMID:10591965, PMID:15466424, PMID:16568252]
synonym: "activation of flocculation via cell wall protein-carbohydrate interaction" NARROW [GOC:TermGenie]
synonym: "up regulation of flocculation via cell wall protein-carbohydrate interaction" EXACT [GOC:TermGenie]
synonym: "up-regulation of flocculation via cell wall protein-carbohydrate interaction" EXACT [GOC:TermGenie]
synonym: "upregulation of flocculation via cell wall protein-carbohydrate interaction" EXACT [GOC:TermGenie]
is_a: GO:1900455 ! regulation of flocculation via cell wall protein-carbohydrate interaction
is_a: GO:1900735 ! positive regulation of flocculation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000501 ! flocculation via cell wall protein-carbohydrate interaction
relationship: positively_regulates GO:0000501 ! flocculation via cell wall protein-carbohydrate interaction
created_by: dgf
creation_date: 2012-05-01T10:28:57Z

[Term]
id: GO:1900480
name: regulation of diacylglycerol biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of diacylglycerol biosynthetic process." [GOC:TermGenie]
synonym: "regulation of diacylglycerol anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of diacylglycerol biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of diacylglycerol formation" EXACT [GOC:TermGenie]
synonym: "regulation of diacylglycerol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0046890 ! regulation of lipid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006651 ! diacylglycerol biosynthetic process
relationship: regulates GO:0006651 ! diacylglycerol biosynthetic process
created_by: al
creation_date: 2012-05-02T10:08:59Z

[Term]
id: GO:1900481
name: negative regulation of diacylglycerol biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of diacylglycerol biosynthetic process." [GOC:TermGenie]
synonym: "down regulation of diacylglycerol anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of diacylglycerol biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of diacylglycerol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of diacylglycerol formation" EXACT [GOC:TermGenie]
synonym: "down regulation of diacylglycerol synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of diacylglycerol anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of diacylglycerol biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of diacylglycerol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of diacylglycerol formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of diacylglycerol synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of diacylglycerol anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of diacylglycerol biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of diacylglycerol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of diacylglycerol formation" EXACT [GOC:TermGenie]
synonym: "downregulation of diacylglycerol synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of diacylglycerol anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of diacylglycerol biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of diacylglycerol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of diacylglycerol formation" EXACT [GOC:TermGenie]
synonym: "inhibition of diacylglycerol synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of diacylglycerol anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of diacylglycerol biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of diacylglycerol formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of diacylglycerol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0051055 ! negative regulation of lipid biosynthetic process
is_a: GO:1900480 ! regulation of diacylglycerol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006651 ! diacylglycerol biosynthetic process
relationship: negatively_regulates GO:0006651 ! diacylglycerol biosynthetic process
created_by: al
creation_date: 2012-05-02T10:09:09Z

[Term]
id: GO:1900482
name: positive regulation of diacylglycerol biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of diacylglycerol biosynthetic process." [GOC:TermGenie]
synonym: "activation of diacylglycerol anabolism" EXACT [GOC:TermGenie]
synonym: "activation of diacylglycerol biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of diacylglycerol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of diacylglycerol formation" EXACT [GOC:TermGenie]
synonym: "activation of diacylglycerol synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of diacylglycerol anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of diacylglycerol biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of diacylglycerol formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of diacylglycerol synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of diacylglycerol anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of diacylglycerol biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of diacylglycerol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of diacylglycerol formation" EXACT [GOC:TermGenie]
synonym: "up regulation of diacylglycerol synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of diacylglycerol anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of diacylglycerol biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of diacylglycerol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of diacylglycerol formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of diacylglycerol synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of diacylglycerol anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of diacylglycerol biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of diacylglycerol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of diacylglycerol formation" EXACT [GOC:TermGenie]
synonym: "upregulation of diacylglycerol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0046889 ! positive regulation of lipid biosynthetic process
is_a: GO:1900480 ! regulation of diacylglycerol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006651 ! diacylglycerol biosynthetic process
relationship: positively_regulates GO:0006651 ! diacylglycerol biosynthetic process
created_by: al
creation_date: 2012-05-02T10:09:18Z

[Term]
id: GO:1900483
name: regulation of protein targeting to vacuolar membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein targeting to vacuolar membrane." [GOC:TermGenie]
is_a: GO:0090313 ! regulation of protein targeting to membrane
is_a: GO:1903335 ! regulation of vacuolar transport
is_a: GO:1903649 ! regulation of cytoplasmic transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044395 ! protein targeting to vacuolar membrane
relationship: regulates GO:0044395 ! protein targeting to vacuolar membrane
created_by: al
creation_date: 2012-05-02T10:13:23Z

[Term]
id: GO:1900484
name: negative regulation of protein targeting to vacuolar membrane
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein targeting to vacuolar membrane." [GOC:TermGenie]
synonym: "down regulation of protein targeting to vacuolar membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein targeting to vacuolar membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of protein targeting to vacuolar membrane" EXACT [GOC:TermGenie]
synonym: "inhibition of protein targeting to vacuolar membrane" NARROW [GOC:TermGenie]
is_a: GO:0090315 ! negative regulation of protein targeting to membrane
is_a: GO:1900483 ! regulation of protein targeting to vacuolar membrane
is_a: GO:1903336 ! negative regulation of vacuolar transport
is_a: GO:1903650 ! negative regulation of cytoplasmic transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044395 ! protein targeting to vacuolar membrane
relationship: negatively_regulates GO:0044395 ! protein targeting to vacuolar membrane
created_by: al
creation_date: 2012-05-02T10:13:33Z

[Term]
id: GO:1900485
name: positive regulation of protein targeting to vacuolar membrane
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein targeting to vacuolar membrane." [GOC:TermGenie]
synonym: "activation of protein targeting to vacuolar membrane" NARROW [GOC:TermGenie]
synonym: "up regulation of protein targeting to vacuolar membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein targeting to vacuolar membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of protein targeting to vacuolar membrane" EXACT [GOC:TermGenie]
is_a: GO:0090314 ! positive regulation of protein targeting to membrane
is_a: GO:1900483 ! regulation of protein targeting to vacuolar membrane
is_a: GO:1903337 ! positive regulation of vacuolar transport
is_a: GO:1903651 ! positive regulation of cytoplasmic transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044395 ! protein targeting to vacuolar membrane
relationship: positively_regulates GO:0044395 ! protein targeting to vacuolar membrane
created_by: al
creation_date: 2012-05-02T10:13:41Z

[Term]
id: GO:1900486
name: positive regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of isopentenyl diphosphate biosynthetic process, mevalonate pathway." [GOC:TermGenie]
synonym: "activation of Ac-MVA pathway" EXACT [GOC:TermGenie]
synonym: "activation of acetate-mevalonate pathway" EXACT [GOC:TermGenie]
synonym: "activation of isopentenyl diphosphate anabolism, mevalonate pathway" EXACT [GOC:TermGenie]
synonym: "activation of isopentenyl diphosphate biosynthetic process, mevalonate pathway" NARROW [GOC:TermGenie]
synonym: "activation of isopentenyl diphosphate formation, mevalonate pathway" EXACT [GOC:TermGenie]
synonym: "activation of isopentenyl diphosphate synthesis, mevalonate pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of Ac-MVA pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of acetate-mevalonate pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of isopentenyl diphosphate anabolism, mevalonate pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of isopentenyl diphosphate formation, mevalonate pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of isopentenyl diphosphate synthesis, mevalonate pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of Ac-MVA pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of acetate-mevalonate pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of isopentenyl diphosphate anabolism, mevalonate pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of isopentenyl diphosphate formation, mevalonate pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of isopentenyl diphosphate synthesis, mevalonate pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of Ac-MVA pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of acetate-mevalonate pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of isopentenyl diphosphate anabolism, mevalonate pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of isopentenyl diphosphate formation, mevalonate pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of isopentenyl diphosphate synthesis, mevalonate pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of Ac-MVA pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of acetate-mevalonate pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of isopentenyl diphosphate anabolism, mevalonate pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of isopentenyl diphosphate formation, mevalonate pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of isopentenyl diphosphate synthesis, mevalonate pathway" EXACT [GOC:TermGenie]
is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process
is_a: GO:0051176 ! positive regulation of sulfur metabolic process
is_a: GO:0051197 ! positive regulation of coenzyme metabolic process
is_a: GO:0071073 ! positive regulation of phospholipid biosynthetic process
is_a: GO:2001210 ! regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0019287 ! isopentenyl diphosphate biosynthetic process, mevalonate pathway
relationship: positively_regulates GO:0019287 ! isopentenyl diphosphate biosynthetic process, mevalonate pathway
created_by: al
creation_date: 2012-05-02T10:46:46Z

[Term]
id: GO:1900487
name: regulation of [2Fe-2S] cluster assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of [2Fe-2S] cluster assembly." [GOC:mengo_curators, GOC:pr, GOC:TermGenie]
synonym: "regulation of 2Fe-2S cluster assembly" EXACT [GOC:TermGenie]
synonym: "regulation of [2Fe-2S] cluster biosynthetic process" RELATED [GOC:TermGenie]
is_a: GO:1903329 ! regulation of iron-sulfur cluster assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044571 ! [2Fe-2S] cluster assembly
relationship: regulates GO:0044571 ! [2Fe-2S] cluster assembly
created_by: tt
creation_date: 2012-05-02T01:22:22Z

[Term]
id: GO:1900488
name: negative regulation of [2Fe-2S] cluster assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of [2Fe-2S] cluster assembly." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of 2Fe-2S cluster assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of [2Fe-2S] cluster assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of [2Fe-2S] cluster biosynthetic process" RELATED [GOC:TermGenie]
synonym: "down-regulation of 2Fe-2S cluster assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of [2Fe-2S] cluster assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of [2Fe-2S] cluster biosynthetic process" RELATED [GOC:TermGenie]
synonym: "downregulation of 2Fe-2S cluster assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of [2Fe-2S] cluster assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of [2Fe-2S] cluster biosynthetic process" RELATED [GOC:TermGenie]
synonym: "inhibition of 2Fe-2S cluster assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of [2Fe-2S] cluster assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of [2Fe-2S] cluster biosynthetic process" RELATED [GOC:TermGenie]
synonym: "negative regulation of 2Fe-2S cluster assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of [2Fe-2S] cluster biosynthetic process" RELATED [GOC:TermGenie]
is_a: GO:1900487 ! regulation of [2Fe-2S] cluster assembly
is_a: GO:1903330 ! negative regulation of iron-sulfur cluster assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044571 ! [2Fe-2S] cluster assembly
relationship: negatively_regulates GO:0044571 ! [2Fe-2S] cluster assembly
created_by: tt
creation_date: 2012-05-02T01:22:32Z

[Term]
id: GO:1900489
name: positive regulation of [2Fe-2S] cluster assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of [2Fe-2S] cluster assembly." [GOC:mengo_curators, GOC:pr, GOC:TermGenie]
synonym: "activation of 2Fe-2S cluster assembly" NARROW [GOC:TermGenie]
synonym: "activation of [2Fe-2S] cluster assembly" NARROW [GOC:TermGenie]
synonym: "activation of [2Fe-2S] cluster biosynthetic process" RELATED [GOC:TermGenie]
synonym: "positive regulation of 2Fe-2S cluster assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of [2Fe-2S] cluster biosynthetic process" RELATED [GOC:TermGenie]
synonym: "up regulation of 2Fe-2S cluster assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of [2Fe-2S] cluster assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of [2Fe-2S] cluster biosynthetic process" RELATED [GOC:TermGenie]
synonym: "up-regulation of 2Fe-2S cluster assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of [2Fe-2S] cluster assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of [2Fe-2S] cluster biosynthetic process" RELATED [GOC:TermGenie]
synonym: "upregulation of 2Fe-2S cluster assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of [2Fe-2S] cluster assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of [2Fe-2S] cluster biosynthetic process" RELATED [GOC:TermGenie]
is_a: GO:1900487 ! regulation of [2Fe-2S] cluster assembly
is_a: GO:1903331 ! positive regulation of iron-sulfur cluster assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044571 ! [2Fe-2S] cluster assembly
relationship: positively_regulates GO:0044571 ! [2Fe-2S] cluster assembly
created_by: tt
creation_date: 2012-05-02T01:22:40Z

[Term]
id: GO:1900490
name: positive regulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hydroxymethylglutaryl-CoA reductase (NADPH) activity." [GOC:TermGenie]
synonym: "activation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity" BROAD [GOC:TermGenie]
synonym: "activation of HMG-CoA reductase activity" BROAD [GOC:TermGenie]
synonym: "activation of hydroxymethylglutaryl-CoA reductase (NADPH) activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity" BROAD [GOC:TermGenie]
synonym: "positive regulation of HMG-CoA reductase activity" BROAD [GOC:TermGenie]
synonym: "up regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity" BROAD [GOC:TermGenie]
synonym: "up regulation of HMG-CoA reductase activity" BROAD [GOC:TermGenie]
synonym: "up regulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity" BROAD [GOC:TermGenie]
synonym: "up-regulation of HMG-CoA reductase activity" BROAD [GOC:TermGenie]
synonym: "up-regulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity" EXACT [GOC:TermGenie]
synonym: "upregulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity" BROAD [GOC:TermGenie]
synonym: "upregulation of HMG-CoA reductase activity" BROAD [GOC:TermGenie]
synonym: "upregulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity" EXACT [GOC:TermGenie]
is_a: GO:0051353 ! positive regulation of oxidoreductase activity
is_a: GO:2001215 ! regulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004420 ! hydroxymethylglutaryl-CoA reductase (NADPH) activity
relationship: positively_regulates GO:0004420 ! hydroxymethylglutaryl-CoA reductase (NADPH) activity
created_by: al
creation_date: 2012-05-02T03:01:43Z

[Term]
id: GO:1900491
name: regulation of [4Fe-4S] cluster assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of [4Fe-4S] cluster assembly." [GOC:mengo_curators, GOC:pr, GOC:TermGenie]
synonym: "regulation of 4Fe-4S cluster assembly" EXACT [GOC:TermGenie]
synonym: "regulation of [4Fe-4S] cluster biosynthetic process" RELATED [GOC:TermGenie]
is_a: GO:1903329 ! regulation of iron-sulfur cluster assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044572 ! [4Fe-4S] cluster assembly
relationship: regulates GO:0044572 ! [4Fe-4S] cluster assembly
created_by: tt
creation_date: 2012-05-02T03:48:49Z

[Term]
id: GO:1900492
name: negative regulation of [4Fe-4S] cluster assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of [4Fe-4S] cluster assembly." [GOC:mengo_curators, GOC:pr, GOC:TermGenie]
synonym: "down regulation of 4Fe-4S cluster assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of [4Fe-4S] cluster assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of [4Fe-4S] cluster biosynthetic process" RELATED [GOC:TermGenie]
synonym: "down-regulation of 4Fe-4S cluster assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of [4Fe-4S] cluster assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of [4Fe-4S] cluster biosynthetic process" RELATED [GOC:TermGenie]
synonym: "downregulation of 4Fe-4S cluster assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of [4Fe-4S] cluster assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of [4Fe-4S] cluster biosynthetic process" RELATED [GOC:TermGenie]
synonym: "inhibition of 4Fe-4S cluster assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of [4Fe-4S] cluster assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of [4Fe-4S] cluster biosynthetic process" RELATED [GOC:TermGenie]
synonym: "negative regulation of 4Fe-4S cluster assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of [4Fe-4S] cluster biosynthetic process" RELATED [GOC:TermGenie]
is_a: GO:1900491 ! regulation of [4Fe-4S] cluster assembly
is_a: GO:1903330 ! negative regulation of iron-sulfur cluster assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044572 ! [4Fe-4S] cluster assembly
relationship: negatively_regulates GO:0044572 ! [4Fe-4S] cluster assembly
created_by: tt
creation_date: 2012-05-02T03:49:00Z

[Term]
id: GO:1900493
name: positive regulation of [4Fe-4S] cluster assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of [4Fe-4S] cluster assembly." [GOC:mengo_curators, GOC:pr, GOC:TermGenie]
synonym: "activation of 4Fe-4S cluster assembly" NARROW [GOC:TermGenie]
synonym: "activation of [4Fe-4S] cluster assembly" NARROW [GOC:TermGenie]
synonym: "activation of [4Fe-4S] cluster biosynthetic process" RELATED [GOC:TermGenie]
synonym: "positive regulation of 4Fe-4S cluster assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of [4Fe-4S] cluster biosynthetic process" RELATED [GOC:TermGenie]
synonym: "up regulation of 4Fe-4S cluster assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of [4Fe-4S] cluster assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of [4Fe-4S] cluster biosynthetic process" RELATED [GOC:TermGenie]
synonym: "up-regulation of 4Fe-4S cluster assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of [4Fe-4S] cluster assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of [4Fe-4S] cluster biosynthetic process" RELATED [GOC:TermGenie]
synonym: "upregulation of 4Fe-4S cluster assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of [4Fe-4S] cluster assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of [4Fe-4S] cluster biosynthetic process" RELATED [GOC:TermGenie]
is_a: GO:1900491 ! regulation of [4Fe-4S] cluster assembly
is_a: GO:1903331 ! positive regulation of iron-sulfur cluster assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044572 ! [4Fe-4S] cluster assembly
relationship: positively_regulates GO:0044572 ! [4Fe-4S] cluster assembly
created_by: tt
creation_date: 2012-05-02T03:49:10Z

[Term]
id: GO:1900494
name: regulation of butyryl-CoA biosynthetic process from acetyl-CoA
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of butyryl-CoA biosynthetic process from acetyl-CoA." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of butyryl-CoA biosynthesis from acetyl-CoA" EXACT [GOC:TermGenie]
is_a: GO:0042304 ! regulation of fatty acid biosynthetic process
is_a: GO:0050812 ! regulation of acyl-CoA biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044579 ! butyryl-CoA biosynthetic process from acetyl-CoA
relationship: regulates GO:0044579 ! butyryl-CoA biosynthetic process from acetyl-CoA
created_by: tt
creation_date: 2012-05-02T03:51:38Z

[Term]
id: GO:1900495
name: negative regulation of butyryl-CoA biosynthetic process from acetyl-CoA
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of butyryl-CoA biosynthetic process from acetyl-CoA." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of butyryl-CoA biosynthesis from acetyl-CoA" EXACT [GOC:TermGenie]
synonym: "down regulation of butyryl-CoA biosynthetic process from acetyl-CoA" EXACT [GOC:TermGenie]
synonym: "down-regulation of butyryl-CoA biosynthesis from acetyl-CoA" EXACT [GOC:TermGenie]
synonym: "down-regulation of butyryl-CoA biosynthetic process from acetyl-CoA" EXACT [GOC:TermGenie]
synonym: "downregulation of butyryl-CoA biosynthesis from acetyl-CoA" EXACT [GOC:TermGenie]
synonym: "downregulation of butyryl-CoA biosynthetic process from acetyl-CoA" EXACT [GOC:TermGenie]
synonym: "inhibition of butyryl-CoA biosynthesis from acetyl-CoA" EXACT [GOC:TermGenie]
synonym: "inhibition of butyryl-CoA biosynthetic process from acetyl-CoA" NARROW [GOC:TermGenie]
synonym: "negative regulation of butyryl-CoA biosynthesis from acetyl-CoA" EXACT [GOC:TermGenie]
is_a: GO:0010563 ! negative regulation of phosphorus metabolic process
is_a: GO:0045717 ! negative regulation of fatty acid biosynthetic process
is_a: GO:0051175 ! negative regulation of sulfur metabolic process
is_a: GO:0051198 ! negative regulation of coenzyme metabolic process
is_a: GO:1900494 ! regulation of butyryl-CoA biosynthetic process from acetyl-CoA
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044579 ! butyryl-CoA biosynthetic process from acetyl-CoA
relationship: negatively_regulates GO:0044579 ! butyryl-CoA biosynthetic process from acetyl-CoA
created_by: tt
creation_date: 2012-05-02T03:51:49Z

[Term]
id: GO:1900496
name: positive regulation of butyryl-CoA biosynthetic process from acetyl-CoA
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of butyryl-CoA biosynthetic process from acetyl-CoA." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of butyryl-CoA biosynthesis from acetyl-CoA" EXACT [GOC:TermGenie]
synonym: "activation of butyryl-CoA biosynthetic process from acetyl-CoA" NARROW [GOC:TermGenie]
synonym: "positive regulation of butyryl-CoA biosynthesis from acetyl-CoA" EXACT [GOC:TermGenie]
synonym: "up regulation of butyryl-CoA biosynthesis from acetyl-CoA" EXACT [GOC:TermGenie]
synonym: "up regulation of butyryl-CoA biosynthetic process from acetyl-CoA" EXACT [GOC:TermGenie]
synonym: "up-regulation of butyryl-CoA biosynthesis from acetyl-CoA" EXACT [GOC:TermGenie]
synonym: "up-regulation of butyryl-CoA biosynthetic process from acetyl-CoA" EXACT [GOC:TermGenie]
synonym: "upregulation of butyryl-CoA biosynthesis from acetyl-CoA" EXACT [GOC:TermGenie]
synonym: "upregulation of butyryl-CoA biosynthetic process from acetyl-CoA" EXACT [GOC:TermGenie]
is_a: GO:0010562 ! positive regulation of phosphorus metabolic process
is_a: GO:0045723 ! positive regulation of fatty acid biosynthetic process
is_a: GO:0051176 ! positive regulation of sulfur metabolic process
is_a: GO:0051197 ! positive regulation of coenzyme metabolic process
is_a: GO:1900494 ! regulation of butyryl-CoA biosynthetic process from acetyl-CoA
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044579 ! butyryl-CoA biosynthetic process from acetyl-CoA
relationship: positively_regulates GO:0044579 ! butyryl-CoA biosynthetic process from acetyl-CoA
created_by: tt
creation_date: 2012-05-02T03:51:58Z

[Term]
id: GO:1900497
name: regulation of butyryl-CoA catabolic process to butanol
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of butyryl-CoA catabolic process to butanol." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of butyryl-CoA catabolism to butanol" EXACT [GOC:TermGenie]
is_a: GO:0019217 ! regulation of fatty acid metabolic process
is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
is_a: GO:0050994 ! regulation of lipid catabolic process
is_a: GO:0051174 ! regulation of phosphorus metabolic process
is_a: GO:0051196 ! regulation of coenzyme metabolic process
is_a: GO:1902930 ! regulation of alcohol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044582 ! butyryl-CoA catabolic process to butanol
relationship: regulates GO:0044582 ! butyryl-CoA catabolic process to butanol
created_by: tt
creation_date: 2012-05-02T03:53:20Z

[Term]
id: GO:1900498
name: negative regulation of butyryl-CoA catabolic process to butanol
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of butyryl-CoA catabolic process to butanol." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of butyryl-CoA catabolic process to butanol" EXACT [GOC:TermGenie]
synonym: "down regulation of butyryl-CoA catabolism to butanol" EXACT [GOC:TermGenie]
synonym: "down-regulation of butyryl-CoA catabolic process to butanol" EXACT [GOC:TermGenie]
synonym: "down-regulation of butyryl-CoA catabolism to butanol" EXACT [GOC:TermGenie]
synonym: "downregulation of butyryl-CoA catabolic process to butanol" EXACT [GOC:TermGenie]
synonym: "downregulation of butyryl-CoA catabolism to butanol" EXACT [GOC:TermGenie]
synonym: "inhibition of butyryl-CoA catabolic process to butanol" NARROW [GOC:TermGenie]
synonym: "inhibition of butyryl-CoA catabolism to butanol" EXACT [GOC:TermGenie]
synonym: "negative regulation of butyryl-CoA catabolism to butanol" EXACT [GOC:TermGenie]
is_a: GO:0010563 ! negative regulation of phosphorus metabolic process
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:0045922 ! negative regulation of fatty acid metabolic process
is_a: GO:0050995 ! negative regulation of lipid catabolic process
is_a: GO:0051175 ! negative regulation of sulfur metabolic process
is_a: GO:0051198 ! negative regulation of coenzyme metabolic process
is_a: GO:1900497 ! regulation of butyryl-CoA catabolic process to butanol
is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044582 ! butyryl-CoA catabolic process to butanol
relationship: negatively_regulates GO:0044582 ! butyryl-CoA catabolic process to butanol
created_by: tt
creation_date: 2012-05-02T03:53:31Z

[Term]
id: GO:1900499
name: positive regulation of butyryl-CoA catabolic process to butanol
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of butyryl-CoA catabolic process to butanol." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of butyryl-CoA catabolic process to butanol" NARROW [GOC:TermGenie]
synonym: "activation of butyryl-CoA catabolism to butanol" EXACT [GOC:TermGenie]
synonym: "positive regulation of butyryl-CoA catabolism to butanol" EXACT [GOC:TermGenie]
synonym: "up regulation of butyryl-CoA catabolic process to butanol" EXACT [GOC:TermGenie]
synonym: "up regulation of butyryl-CoA catabolism to butanol" EXACT [GOC:TermGenie]
synonym: "up-regulation of butyryl-CoA catabolic process to butanol" EXACT [GOC:TermGenie]
synonym: "up-regulation of butyryl-CoA catabolism to butanol" EXACT [GOC:TermGenie]
synonym: "upregulation of butyryl-CoA catabolic process to butanol" EXACT [GOC:TermGenie]
synonym: "upregulation of butyryl-CoA catabolism to butanol" EXACT [GOC:TermGenie]
is_a: GO:0010562 ! positive regulation of phosphorus metabolic process
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:0045923 ! positive regulation of fatty acid metabolic process
is_a: GO:0050996 ! positive regulation of lipid catabolic process
is_a: GO:0051176 ! positive regulation of sulfur metabolic process
is_a: GO:0051197 ! positive regulation of coenzyme metabolic process
is_a: GO:1900497 ! regulation of butyryl-CoA catabolic process to butanol
is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044582 ! butyryl-CoA catabolic process to butanol
relationship: positively_regulates GO:0044582 ! butyryl-CoA catabolic process to butanol
created_by: tt
creation_date: 2012-05-02T03:53:40Z

[Term]
id: GO:1900500
name: regulation of butyryl-CoA catabolic process to butyrate
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of butyryl-CoA catabolic process to butyrate." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of butyryl-CoA catabolism to butyrate" EXACT [GOC:TermGenie]
is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:0042304 ! regulation of fatty acid biosynthetic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
is_a: GO:0050994 ! regulation of lipid catabolic process
is_a: GO:0051174 ! regulation of phosphorus metabolic process
is_a: GO:0051196 ! regulation of coenzyme metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044581 ! butyryl-CoA catabolic process to butyrate
relationship: regulates GO:0044581 ! butyryl-CoA catabolic process to butyrate
created_by: tt
creation_date: 2012-05-02T03:56:19Z

[Term]
id: GO:1900501
name: negative regulation of butyryl-CoA catabolic process to butyrate
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of butyryl-CoA catabolic process to butyrate." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of butyryl-CoA catabolic process to butyrate" EXACT [GOC:TermGenie]
synonym: "down regulation of butyryl-CoA catabolism to butyrate" EXACT [GOC:TermGenie]
synonym: "down-regulation of butyryl-CoA catabolic process to butyrate" EXACT [GOC:TermGenie]
synonym: "down-regulation of butyryl-CoA catabolism to butyrate" EXACT [GOC:TermGenie]
synonym: "downregulation of butyryl-CoA catabolic process to butyrate" EXACT [GOC:TermGenie]
synonym: "downregulation of butyryl-CoA catabolism to butyrate" EXACT [GOC:TermGenie]
synonym: "inhibition of butyryl-CoA catabolic process to butyrate" NARROW [GOC:TermGenie]
synonym: "inhibition of butyryl-CoA catabolism to butyrate" EXACT [GOC:TermGenie]
synonym: "negative regulation of butyryl-CoA catabolism to butyrate" EXACT [GOC:TermGenie]
is_a: GO:0010563 ! negative regulation of phosphorus metabolic process
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:0045717 ! negative regulation of fatty acid biosynthetic process
is_a: GO:0050995 ! negative regulation of lipid catabolic process
is_a: GO:0051175 ! negative regulation of sulfur metabolic process
is_a: GO:0051198 ! negative regulation of coenzyme metabolic process
is_a: GO:1900500 ! regulation of butyryl-CoA catabolic process to butyrate
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044581 ! butyryl-CoA catabolic process to butyrate
relationship: negatively_regulates GO:0044581 ! butyryl-CoA catabolic process to butyrate
created_by: tt
creation_date: 2012-05-02T03:56:30Z

[Term]
id: GO:1900502
name: positive regulation of butyryl-CoA catabolic process to butyrate
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of butyryl-CoA catabolic process to butyrate." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of butyryl-CoA catabolic process to butyrate" NARROW [GOC:TermGenie]
synonym: "activation of butyryl-CoA catabolism to butyrate" EXACT [GOC:TermGenie]
synonym: "positive regulation of butyryl-CoA catabolism to butyrate" EXACT [GOC:TermGenie]
synonym: "up regulation of butyryl-CoA catabolic process to butyrate" EXACT [GOC:TermGenie]
synonym: "up regulation of butyryl-CoA catabolism to butyrate" EXACT [GOC:TermGenie]
synonym: "up-regulation of butyryl-CoA catabolic process to butyrate" EXACT [GOC:TermGenie]
synonym: "up-regulation of butyryl-CoA catabolism to butyrate" EXACT [GOC:TermGenie]
synonym: "upregulation of butyryl-CoA catabolic process to butyrate" EXACT [GOC:TermGenie]
synonym: "upregulation of butyryl-CoA catabolism to butyrate" EXACT [GOC:TermGenie]
is_a: GO:0010562 ! positive regulation of phosphorus metabolic process
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:0045723 ! positive regulation of fatty acid biosynthetic process
is_a: GO:0050996 ! positive regulation of lipid catabolic process
is_a: GO:0051176 ! positive regulation of sulfur metabolic process
is_a: GO:0051197 ! positive regulation of coenzyme metabolic process
is_a: GO:1900500 ! regulation of butyryl-CoA catabolic process to butyrate
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044581 ! butyryl-CoA catabolic process to butyrate
relationship: positively_regulates GO:0044581 ! butyryl-CoA catabolic process to butyrate
created_by: tt
creation_date: 2012-05-02T03:56:40Z

[Term]
id: GO:1900503
name: regulation of cellulosome assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellulosome assembly." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:1902115 ! regulation of organelle assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044575 ! cellulosome assembly
relationship: regulates GO:0044575 ! cellulosome assembly
created_by: tt
creation_date: 2012-05-02T03:58:15Z

[Term]
id: GO:1900504
name: negative regulation of cellulosome assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellulosome assembly." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of cellulosome assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellulosome assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of cellulosome assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of cellulosome assembly" NARROW [GOC:TermGenie]
is_a: GO:1900503 ! regulation of cellulosome assembly
is_a: GO:1902116 ! negative regulation of organelle assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044575 ! cellulosome assembly
relationship: negatively_regulates GO:0044575 ! cellulosome assembly
created_by: tt
creation_date: 2012-05-02T03:58:26Z

[Term]
id: GO:1900505
name: positive regulation of cellulosome assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellulosome assembly." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of cellulosome assembly" NARROW [GOC:TermGenie]
synonym: "up regulation of cellulosome assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellulosome assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of cellulosome assembly" EXACT [GOC:TermGenie]
is_a: GO:1900503 ! regulation of cellulosome assembly
is_a: GO:1902117 ! positive regulation of organelle assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044575 ! cellulosome assembly
relationship: positively_regulates GO:0044575 ! cellulosome assembly
created_by: tt
creation_date: 2012-05-02T03:58:35Z

[Term]
id: GO:1900506
name: regulation of iron-sulfur-molybdenum cofactor assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of iron-sulfur-molybdenum cofactor assembly." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of FeMoco assembly" EXACT [GOC:TermGenie]
synonym: "regulation of FeMoco biosynthetic process" EXACT [GOC:TermGenie]
synonym: "regulation of iron molybdenum cofactor assembly" EXACT [GOC:TermGenie]
synonym: "regulation of iron molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of iron molybdenum cofactor biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0051193 ! regulation of cofactor metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044593 ! iron-sulfur-molybdenum cofactor assembly
relationship: regulates GO:0044593 ! iron-sulfur-molybdenum cofactor assembly
created_by: tt
creation_date: 2012-05-02T04:02:16Z

[Term]
id: GO:1900507
name: negative regulation of iron-sulfur-molybdenum cofactor assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of iron-sulfur-molybdenum cofactor assembly." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of FeMoco assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of FeMoco biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of iron molybdenum cofactor assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of iron molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of iron molybdenum cofactor biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of iron-sulfur-molybdenum cofactor assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of FeMoco assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of FeMoco biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of iron molybdenum cofactor assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of iron molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of iron molybdenum cofactor biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of iron-sulfur-molybdenum cofactor assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of FeMoco assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of FeMoco biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of iron molybdenum cofactor assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of iron molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of iron molybdenum cofactor biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of iron-sulfur-molybdenum cofactor assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of FeMoco assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of FeMoco biosynthetic process" EXACT [GOC:TermGenie]
synonym: "inhibition of iron molybdenum cofactor assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of iron molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of iron molybdenum cofactor biosynthetic process" EXACT [GOC:TermGenie]
synonym: "inhibition of iron-sulfur-molybdenum cofactor assembly" NARROW [GOC:TermGenie]
synonym: "negative regulation of FeMoco assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of FeMoco biosynthetic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of iron molybdenum cofactor assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of iron molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of iron molybdenum cofactor biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0051195 ! negative regulation of cofactor metabolic process
is_a: GO:1900506 ! regulation of iron-sulfur-molybdenum cofactor assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044593 ! iron-sulfur-molybdenum cofactor assembly
relationship: negatively_regulates GO:0044593 ! iron-sulfur-molybdenum cofactor assembly
created_by: tt
creation_date: 2012-05-02T04:02:27Z

[Term]
id: GO:1900508
name: positive regulation of iron-sulfur-molybdenum cofactor assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of iron-sulfur-molybdenum cofactor assembly." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of FeMoco assembly" EXACT [GOC:TermGenie]
synonym: "activation of FeMoco biosynthetic process" EXACT [GOC:TermGenie]
synonym: "activation of iron molybdenum cofactor assembly" EXACT [GOC:TermGenie]
synonym: "activation of iron molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of iron molybdenum cofactor biosynthetic process" EXACT [GOC:TermGenie]
synonym: "activation of iron-sulfur-molybdenum cofactor assembly" NARROW [GOC:TermGenie]
synonym: "positive regulation of FeMoco assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of FeMoco biosynthetic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of iron molybdenum cofactor assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of iron molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of iron molybdenum cofactor biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of FeMoco assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of FeMoco biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of iron molybdenum cofactor assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of iron molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of iron molybdenum cofactor biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of iron-sulfur-molybdenum cofactor assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of FeMoco assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of FeMoco biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of iron molybdenum cofactor assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of iron molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of iron molybdenum cofactor biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of iron-sulfur-molybdenum cofactor assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of FeMoco assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of FeMoco biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of iron molybdenum cofactor assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of iron molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of iron molybdenum cofactor biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of iron-sulfur-molybdenum cofactor assembly" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0051194 ! positive regulation of cofactor metabolic process
is_a: GO:1900506 ! regulation of iron-sulfur-molybdenum cofactor assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044593 ! iron-sulfur-molybdenum cofactor assembly
relationship: positively_regulates GO:0044593 ! iron-sulfur-molybdenum cofactor assembly
created_by: tt
creation_date: 2012-05-02T04:02:37Z

[Term]
id: GO:1900509
name: regulation of pentose catabolic process to ethanol
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pentose catabolic process to ethanol." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of pentose catabolism to ethanol" EXACT [GOC:TermGenie]
is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process
is_a: GO:1902930 ! regulation of alcohol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044576 ! pentose catabolic process to ethanol
relationship: regulates GO:0044576 ! pentose catabolic process to ethanol
created_by: tt
creation_date: 2012-05-02T04:04:40Z

[Term]
id: GO:1900510
name: negative regulation of pentose catabolic process to ethanol
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of pentose catabolic process to ethanol." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of pentose catabolic process to ethanol" EXACT [GOC:TermGenie]
synonym: "down regulation of pentose catabolism to ethanol" EXACT [GOC:TermGenie]
synonym: "down-regulation of pentose catabolic process to ethanol" EXACT [GOC:TermGenie]
synonym: "down-regulation of pentose catabolism to ethanol" EXACT [GOC:TermGenie]
synonym: "downregulation of pentose catabolic process to ethanol" EXACT [GOC:TermGenie]
synonym: "downregulation of pentose catabolism to ethanol" EXACT [GOC:TermGenie]
synonym: "inhibition of pentose catabolic process to ethanol" NARROW [GOC:TermGenie]
synonym: "inhibition of pentose catabolism to ethanol" EXACT [GOC:TermGenie]
synonym: "negative regulation of pentose catabolism to ethanol" EXACT [GOC:TermGenie]
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process
is_a: GO:1900509 ! regulation of pentose catabolic process to ethanol
is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044576 ! pentose catabolic process to ethanol
relationship: negatively_regulates GO:0044576 ! pentose catabolic process to ethanol
created_by: tt
creation_date: 2012-05-02T04:04:51Z

[Term]
id: GO:1900511
name: positive regulation of pentose catabolic process to ethanol
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pentose catabolic process to ethanol." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of pentose catabolic process to ethanol" NARROW [GOC:TermGenie]
synonym: "activation of pentose catabolism to ethanol" EXACT [GOC:TermGenie]
synonym: "positive regulation of pentose catabolism to ethanol" EXACT [GOC:TermGenie]
synonym: "up regulation of pentose catabolic process to ethanol" EXACT [GOC:TermGenie]
synonym: "up regulation of pentose catabolism to ethanol" EXACT [GOC:TermGenie]
synonym: "up-regulation of pentose catabolic process to ethanol" EXACT [GOC:TermGenie]
synonym: "up-regulation of pentose catabolism to ethanol" EXACT [GOC:TermGenie]
synonym: "upregulation of pentose catabolic process to ethanol" EXACT [GOC:TermGenie]
synonym: "upregulation of pentose catabolism to ethanol" EXACT [GOC:TermGenie]
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process
is_a: GO:1900509 ! regulation of pentose catabolic process to ethanol
is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044576 ! pentose catabolic process to ethanol
relationship: positively_regulates GO:0044576 ! pentose catabolic process to ethanol
created_by: tt
creation_date: 2012-05-02T04:05:01Z

[Term]
id: GO:1900512
name: regulation of starch utilization system complex assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of starch utilization system complex assembly." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of assembly of starch utilization system complex" EXACT [GOC:TermGenie]
synonym: "regulation of SUS complex assembly" EXACT [GOC:TermGenie]
is_a: GO:0043254 ! regulation of protein complex assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044574 ! starch utilization system complex assembly
relationship: regulates GO:0044574 ! starch utilization system complex assembly
created_by: tt
creation_date: 2012-05-02T04:06:44Z

[Term]
id: GO:1900513
name: negative regulation of starch utilization system complex assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of starch utilization system complex assembly." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of assembly of starch utilization system complex" EXACT [GOC:TermGenie]
synonym: "down regulation of starch utilization system complex assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of SUS complex assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of assembly of starch utilization system complex" EXACT [GOC:TermGenie]
synonym: "down-regulation of starch utilization system complex assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of SUS complex assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of assembly of starch utilization system complex" EXACT [GOC:TermGenie]
synonym: "downregulation of starch utilization system complex assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of SUS complex assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of assembly of starch utilization system complex" EXACT [GOC:TermGenie]
synonym: "inhibition of starch utilization system complex assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of SUS complex assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of assembly of starch utilization system complex" EXACT [GOC:TermGenie]
synonym: "negative regulation of SUS complex assembly" EXACT [GOC:TermGenie]
is_a: GO:0031333 ! negative regulation of protein complex assembly
is_a: GO:1900512 ! regulation of starch utilization system complex assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044574 ! starch utilization system complex assembly
relationship: negatively_regulates GO:0044574 ! starch utilization system complex assembly
created_by: tt
creation_date: 2012-05-02T04:06:54Z

[Term]
id: GO:1900514
name: positive regulation of starch utilization system complex assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of starch utilization system complex assembly." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of assembly of starch utilization system complex" EXACT [GOC:TermGenie]
synonym: "activation of starch utilization system complex assembly" NARROW [GOC:TermGenie]
synonym: "activation of SUS complex assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of assembly of starch utilization system complex" EXACT [GOC:TermGenie]
synonym: "positive regulation of SUS complex assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of assembly of starch utilization system complex" EXACT [GOC:TermGenie]
synonym: "up regulation of starch utilization system complex assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of SUS complex assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of assembly of starch utilization system complex" EXACT [GOC:TermGenie]
synonym: "up-regulation of starch utilization system complex assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of SUS complex assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of assembly of starch utilization system complex" EXACT [GOC:TermGenie]
synonym: "upregulation of starch utilization system complex assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of SUS complex assembly" EXACT [GOC:TermGenie]
is_a: GO:0031334 ! positive regulation of protein complex assembly
is_a: GO:1900512 ! regulation of starch utilization system complex assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044574 ! starch utilization system complex assembly
relationship: positively_regulates GO:0044574 ! starch utilization system complex assembly
created_by: tt
creation_date: 2012-05-02T04:07:04Z

[Term]
id: GO:1900515
name: regulation of xylose catabolic process to ethanol
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of xylose catabolic process to ethanol." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of xylose catabolism to ethanol" EXACT [GOC:TermGenie]
is_a: GO:0043469 ! regulation of D-xylose catabolic process
is_a: GO:1900509 ! regulation of pentose catabolic process to ethanol
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044577 ! xylose catabolic process to ethanol
relationship: regulates GO:0044577 ! xylose catabolic process to ethanol
created_by: tt
creation_date: 2012-05-02T04:09:07Z

[Term]
id: GO:1900516
name: negative regulation of xylose catabolic process to ethanol
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of xylose catabolic process to ethanol." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of xylose catabolic process to ethanol" EXACT [GOC:TermGenie]
synonym: "down regulation of xylose catabolism to ethanol" EXACT [GOC:TermGenie]
synonym: "down-regulation of xylose catabolic process to ethanol" EXACT [GOC:TermGenie]
synonym: "down-regulation of xylose catabolism to ethanol" EXACT [GOC:TermGenie]
synonym: "downregulation of xylose catabolic process to ethanol" EXACT [GOC:TermGenie]
synonym: "downregulation of xylose catabolism to ethanol" EXACT [GOC:TermGenie]
synonym: "inhibition of xylose catabolic process to ethanol" NARROW [GOC:TermGenie]
synonym: "inhibition of xylose catabolism to ethanol" EXACT [GOC:TermGenie]
synonym: "negative regulation of xylose catabolism to ethanol" EXACT [GOC:TermGenie]
is_a: GO:1900510 ! negative regulation of pentose catabolic process to ethanol
is_a: GO:1900515 ! regulation of xylose catabolic process to ethanol
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044577 ! xylose catabolic process to ethanol
relationship: negatively_regulates GO:0044577 ! xylose catabolic process to ethanol
created_by: tt
creation_date: 2012-05-02T04:09:17Z

[Term]
id: GO:1900517
name: positive regulation of xylose catabolic process to ethanol
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of xylose catabolic process to ethanol." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of xylose catabolic process to ethanol" NARROW [GOC:TermGenie]
synonym: "activation of xylose catabolism to ethanol" EXACT [GOC:TermGenie]
synonym: "positive regulation of xylose catabolism to ethanol" EXACT [GOC:TermGenie]
synonym: "up regulation of xylose catabolic process to ethanol" EXACT [GOC:TermGenie]
synonym: "up regulation of xylose catabolism to ethanol" EXACT [GOC:TermGenie]
synonym: "up-regulation of xylose catabolic process to ethanol" EXACT [GOC:TermGenie]
synonym: "up-regulation of xylose catabolism to ethanol" EXACT [GOC:TermGenie]
synonym: "upregulation of xylose catabolic process to ethanol" EXACT [GOC:TermGenie]
synonym: "upregulation of xylose catabolism to ethanol" EXACT [GOC:TermGenie]
is_a: GO:1900511 ! positive regulation of pentose catabolic process to ethanol
is_a: GO:1900515 ! regulation of xylose catabolic process to ethanol
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044577 ! xylose catabolic process to ethanol
relationship: positively_regulates GO:0044577 ! xylose catabolic process to ethanol
created_by: tt
creation_date: 2012-05-02T04:09:26Z

[Term]
id: GO:1900518
name: regulation of response to pullulan
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to pullulan." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0048583 ! regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044592 ! response to pullulan
relationship: regulates GO:0044592 ! response to pullulan
created_by: tt
creation_date: 2012-05-02T04:11:58Z

[Term]
id: GO:1900519
name: negative regulation of response to pullulan
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to pullulan." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of response to pullulan" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to pullulan" EXACT [GOC:TermGenie]
synonym: "downregulation of response to pullulan" EXACT [GOC:TermGenie]
synonym: "inhibition of response to pullulan" NARROW [GOC:TermGenie]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1900518 ! regulation of response to pullulan
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044592 ! response to pullulan
relationship: negatively_regulates GO:0044592 ! response to pullulan
created_by: tt
creation_date: 2012-05-02T04:12:09Z

[Term]
id: GO:1900520
name: positive regulation of response to pullulan
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to pullulan." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of response to pullulan" NARROW [GOC:TermGenie]
synonym: "up regulation of response to pullulan" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to pullulan" EXACT [GOC:TermGenie]
synonym: "upregulation of response to pullulan" EXACT [GOC:TermGenie]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1900518 ! regulation of response to pullulan
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044592 ! response to pullulan
relationship: positively_regulates GO:0044592 ! response to pullulan
created_by: tt
creation_date: 2012-05-02T04:12:19Z

[Term]
id: GO:1900521
name: regulation of response to amylopectin
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to amylopectin." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0048583 ! regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044591 ! response to amylopectin
relationship: regulates GO:0044591 ! response to amylopectin
created_by: tt
creation_date: 2012-05-02T04:13:51Z

[Term]
id: GO:1900522
name: negative regulation of response to amylopectin
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to amylopectin." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of response to amylopectin" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to amylopectin" EXACT [GOC:TermGenie]
synonym: "downregulation of response to amylopectin" EXACT [GOC:TermGenie]
synonym: "inhibition of response to amylopectin" NARROW [GOC:TermGenie]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1900521 ! regulation of response to amylopectin
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044591 ! response to amylopectin
relationship: negatively_regulates GO:0044591 ! response to amylopectin
created_by: tt
creation_date: 2012-05-02T04:14:01Z

[Term]
id: GO:1900523
name: positive regulation of response to amylopectin
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to amylopectin." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of response to amylopectin" NARROW [GOC:TermGenie]
synonym: "up regulation of response to amylopectin" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to amylopectin" EXACT [GOC:TermGenie]
synonym: "upregulation of response to amylopectin" EXACT [GOC:TermGenie]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1900521 ! regulation of response to amylopectin
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044591 ! response to amylopectin
relationship: positively_regulates GO:0044591 ! response to amylopectin
created_by: tt
creation_date: 2012-05-02T04:14:11Z

[Term]
id: GO:1900524
name: positive regulation of flocculation via cell wall protein-carbohydrate interaction by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of flocculation via cell wall protein-carbohydrate interaction process by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:10591965, PMID:15466424, PMID:16568252]
synonym: "activation of flocculation via cell wall protein-carbohydrate interaction by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "up regulation of flocculation via cell wall protein-carbohydrate interaction by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of flocculation via cell wall protein-carbohydrate interaction by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of flocculation via cell wall protein-carbohydrate interaction by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
is_a: GO:1900479 ! positive regulation of flocculation via cell wall protein-carbohydrate interaction
intersection_of: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
intersection_of: positively_regulates GO:0000501 ! flocculation via cell wall protein-carbohydrate interaction
relationship: positively_regulates GO:0000501 ! flocculation via cell wall protein-carbohydrate interaction
created_by: dgf
creation_date: 2012-05-03T05:13:41Z

[Term]
id: GO:1900525
name: positive regulation of phosphatidylserine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phosphatidylserine biosynthetic process by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:8056324, PMID:8614637]
synonym: "activation of phosphatidylserine anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "activation of phosphatidylserine biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "activation of phosphatidylserine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "activation of phosphatidylserine formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "activation of phosphatidylserine synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphatidylserine anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphatidylserine biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphatidylserine formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphatidylserine synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphatidylserine anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphatidylserine biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphatidylserine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphatidylserine formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphatidylserine synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphatidylserine anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphatidylserine biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphatidylserine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphatidylserine formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphatidylserine synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphatidylserine anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphatidylserine biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphatidylserine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphatidylserine formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphatidylserine synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_a: GO:0072366 ! regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter
is_a: GO:1900413 ! positive regulation of phospholipid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter
is_a: GO:1900470 ! positive regulation of phosphatidylserine biosynthetic process
intersection_of: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
intersection_of: positively_regulates GO:0006659 ! phosphatidylserine biosynthetic process
relationship: positively_regulates GO:0006659 ! phosphatidylserine biosynthetic process
created_by: dgf
creation_date: 2012-05-03T05:13:55Z

[Term]
id: GO:1900526
name: negative regulation of phosphatidylserine biosynthetic process by negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of phosphatidylserine biosynthetic process by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:8056324]
synonym: "negative regulation of phosphatidylserine anabolism by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphatidylserine biosynthesis by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphatidylserine formation by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphatidylserine synthesis by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_a: GO:1900403 ! negative regulation of cellular amino acid biosynthetic process by negative regulation of transcription from RNA polymerase II promoter
is_a: GO:1900469 ! negative regulation of phosphatidylserine biosynthetic process
is_a: GO:1900470 ! positive regulation of phosphatidylserine biosynthetic process
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: negatively_regulates GO:0100056 ! negative regulation of phosphatidylserine biosynthetic process by transcription from RNA polymerase II promoter
relationship: negatively_regulates GO:0100056 ! negative regulation of phosphatidylserine biosynthetic process by transcription from RNA polymerase II promoter
created_by: dgf
creation_date: 2012-05-03T05:14:10Z

[Term]
id: GO:1900527
name: obsolete regulation of nucleus size involved in G1 to G0 transition
namespace: biological_process
def: "OBSOLETE. Any regulation of nucleus size that is involved in G1 to G0 transition." [GOC:al, GOC:TermGenie, PMID:19366728]
comment: This term was made obsolete because it represents a phenotype.
synonym: "regulation of nuclear size involved in cell cycle quiescence" RELATED [GOC:TermGenie]
synonym: "regulation of nuclear size involved in establishment of cell quiescence" EXACT [GOC:TermGenie]
synonym: "regulation of nuclear size involved in G1 to G0 transition" EXACT [GOC:TermGenie]
synonym: "regulation of nuclear size involved in G1/G0 transition" EXACT [GOC:TermGenie]
synonym: "regulation of nuclear size involved in stationary phase" RELATED [GOC:TermGenie]
synonym: "regulation of nuclear volume involved in cell cycle quiescence" RELATED [GOC:TermGenie]
synonym: "regulation of nuclear volume involved in establishment of cell quiescence" EXACT [GOC:TermGenie]
synonym: "regulation of nuclear volume involved in G1 to G0 transition" EXACT [GOC:TermGenie]
synonym: "regulation of nuclear volume involved in G1/G0 transition" EXACT [GOC:TermGenie]
synonym: "regulation of nuclear volume involved in stationary phase" RELATED [GOC:TermGenie]
synonym: "regulation of nucleus size involved in cell cycle quiescence" RELATED [GOC:TermGenie]
synonym: "regulation of nucleus size involved in establishment of cell quiescence" EXACT [GOC:TermGenie]
synonym: "regulation of nucleus size involved in G1 to G0 transition" EXACT []
synonym: "regulation of nucleus size involved in G1/G0 transition" EXACT [GOC:TermGenie]
synonym: "regulation of nucleus size involved in stationary phase" RELATED [GOC:TermGenie]
is_obsolete: true
created_by: al
creation_date: 2012-05-08T10:39:01Z

[Term]
id: GO:1900528
name: obsolete regulation of cell shape involved in G1 to G0 transition
namespace: biological_process
def: "OBSOLETE. Any regulation of cell shape that is involved in G1 to G0 transition." [GOC:al, GOC:TermGenie, PMID:19366728]
comment: This term was made obsolete because it represents a phenotype.
synonym: "regulation of cell shape involved in cell cycle quiescence" RELATED [GOC:TermGenie]
synonym: "regulation of cell shape involved in establishment of cell quiescence" EXACT [GOC:TermGenie]
synonym: "regulation of cell shape involved in G1 to G0 transition" EXACT []
synonym: "regulation of cell shape involved in G1/G0 transition" EXACT [GOC:TermGenie]
synonym: "regulation of cell shape involved in stationary phase" RELATED [GOC:TermGenie]
is_obsolete: true
created_by: al
creation_date: 2012-05-08T10:42:45Z

[Term]
id: GO:1900529
name: obsolete regulation of cell shape involved in cellular response to glucose starvation
namespace: biological_process
def: "OBSOLETE. Any regulation of cell shape that is involved in cellular response to glucose starvation." [GOC:al, GOC:TermGenie, PMID:9135147]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "regulation of cell shape involved in cellular response to glucose starvation" EXACT []
is_obsolete: true
created_by: al
creation_date: 2012-05-08T01:43:38Z

[Term]
id: GO:1900530
name: obsolete regulation of cell shape involved in cellular response to salt stress
namespace: biological_process
def: "OBSOLETE. Any regulation of cell shape that is involved in cellular response to salt stress." [GOC:al, GOC:TermGenie, PMID:9135147]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "regulation of cell shape involved in cellular response to salt stress" EXACT []
synonym: "regulation of cell shape of cellular response to ionic osmotic stress" EXACT [GOC:TermGenie]
synonym: "regulation of cell shape of cellular response to salt stress" EXACT [GOC:TermGenie]
synonym: "regulation of cell shape of cellular salinity response" EXACT [GOC:TermGenie]
is_obsolete: true
created_by: al
creation_date: 2012-05-08T01:48:01Z

[Term]
id: GO:1900531
name: obsolete regulation of cell shape involved in cellular response to heat
namespace: biological_process
def: "OBSOLETE. Any regulation of cell shape that is involved in cellular response to heat." [GOC:al, GOC:TermGenie, PMID:9135147]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "regulation of cell shape involved in cellular response to heat" EXACT []
synonym: "regulation of cell shape of cellular response to heat" EXACT [GOC:TermGenie]
synonym: "regulation of cell shape of cellular response to heat stress" EXACT [GOC:TermGenie]
is_obsolete: true
created_by: al
creation_date: 2012-05-08T01:51:00Z

[Term]
id: GO:1900532
name: obsolete negative regulation of cell proliferation involved in cellular hyperosmotic response
namespace: biological_process
def: "OBSOLETE. negative regulation of cell proliferation during cellular hyperosmotic response" [GOC:TermGenie]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "down regulation of cell proliferation of cellular HOG response" EXACT [GOC:TermGenie]
synonym: "down regulation of cell proliferation of cellular hyperosmotic response" EXACT [GOC:TermGenie]
synonym: "down regulation of cell proliferation of cellular hypertonic response" EXACT [GOC:TermGenie]
synonym: "down regulation of cell proliferation of cellular response to hypertonicity" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell proliferation of cellular HOG response" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell proliferation of cellular hyperosmotic response" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell proliferation of cellular hypertonic response" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell proliferation of cellular response to hypertonicity" EXACT [GOC:TermGenie]
synonym: "downregulation of cell proliferation of cellular HOG response" EXACT [GOC:TermGenie]
synonym: "downregulation of cell proliferation of cellular hyperosmotic response" EXACT [GOC:TermGenie]
synonym: "downregulation of cell proliferation of cellular hypertonic response" EXACT [GOC:TermGenie]
synonym: "downregulation of cell proliferation of cellular response to hypertonicity" EXACT [GOC:TermGenie]
synonym: "inhibition of cell proliferation of cellular HOG response" NARROW [GOC:TermGenie]
synonym: "inhibition of cell proliferation of cellular hyperosmotic response" NARROW [GOC:TermGenie]
synonym: "inhibition of cell proliferation of cellular hypertonic response" NARROW [GOC:TermGenie]
synonym: "inhibition of cell proliferation of cellular response to hypertonicity" NARROW [GOC:TermGenie]
synonym: "negative regulation of cell proliferation involved in cellular hyperosmotic response" EXACT []
synonym: "negative regulation of cell proliferation of cellular HOG response" EXACT [GOC:TermGenie]
synonym: "negative regulation of cell proliferation of cellular hyperosmotic response" EXACT [GOC:TermGenie]
synonym: "negative regulation of cell proliferation of cellular hypertonic response" EXACT [GOC:TermGenie]
synonym: "negative regulation of cell proliferation of cellular response to hypertonicity" EXACT [GOC:TermGenie]
is_obsolete: true
created_by: al
creation_date: 2012-05-08T02:42:52Z

[Term]
id: GO:1900533
name: palmitic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving palmitic acid." [GOC:TermGenie]
is_a: GO:0001676 ! long-chain fatty acid metabolic process
created_by: tb
creation_date: 2012-05-09T07:03:55Z

[Term]
id: GO:1900534
name: palmitic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of palmitic acid." [GOC:TermGenie]
is_a: GO:0042758 ! long-chain fatty acid catabolic process
is_a: GO:1900533 ! palmitic acid metabolic process
created_by: tb
creation_date: 2012-05-09T07:04:56Z

[Term]
id: GO:1900535
name: palmitic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of palmitic acid." [GOC:TermGenie]
is_a: GO:0042759 ! long-chain fatty acid biosynthetic process
is_a: GO:1900533 ! palmitic acid metabolic process
created_by: tb
creation_date: 2012-05-09T07:05:17Z

[Term]
id: GO:1900536
name: obsolete regulation of glucose homeostasis
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of glucose homeostasis." [GOC:TermGenie]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "regulation of glucose homeostasis" EXACT []
is_obsolete: true
created_by: hjd
creation_date: 2012-05-10T06:52:21Z

[Term]
id: GO:1900537
name: obsolete negative regulation of glucose homeostasis
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of glucose homeostasis." [GOC:TermGenie]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "down regulation of glucose homeostasis" EXACT [GOC:TermGenie]
synonym: "down-regulation of glucose homeostasis" EXACT [GOC:TermGenie]
synonym: "downregulation of glucose homeostasis" EXACT [GOC:TermGenie]
synonym: "inhibition of glucose homeostasis" NARROW [GOC:TermGenie]
synonym: "negative regulation of glucose homeostasis" EXACT []
is_obsolete: true
created_by: hjd
creation_date: 2012-05-10T06:53:14Z

[Term]
id: GO:1900538
name: obsolete positive regulation of glucose homeostasis
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of glucose homeostasis." [GOC:TermGenie]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "activation of glucose homeostasis" NARROW [GOC:TermGenie]
synonym: "positive regulation of glucose homeostasis" EXACT []
synonym: "up regulation of glucose homeostasis" EXACT [GOC:TermGenie]
synonym: "up-regulation of glucose homeostasis" EXACT [GOC:TermGenie]
synonym: "upregulation of glucose homeostasis" EXACT [GOC:TermGenie]
is_obsolete: true
created_by: hjd
creation_date: 2012-05-10T06:53:38Z

[Term]
id: GO:1900539
name: fumonisin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fumonisin." [GOC:TermGenie]
synonym: "fumonisin metabolism" RELATED []
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process
created_by: tb
creation_date: 2012-05-11T12:53:29Z

[Term]
id: GO:1900540
name: fumonisin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of fumonisin." [GOC:TermGenie]
synonym: "fumonisin breakdown" EXACT []
synonym: "fumonisin catabolism" EXACT []
synonym: "fumonisin degradation" RELATED []
is_a: GO:0046395 ! carboxylic acid catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900539 ! fumonisin metabolic process
created_by: tb
creation_date: 2012-05-11T12:54:12Z

[Term]
id: GO:1900541
name: fumonisin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of fumonisin." [GOC:TermGenie]
synonym: "fumonisin anabolism" EXACT []
synonym: "fumonisin biosynthesis" EXACT []
synonym: "fumonisin formation" EXACT []
synonym: "fumonisin synthesis" EXACT []
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
is_a: GO:1900539 ! fumonisin metabolic process
created_by: tb
creation_date: 2012-05-11T12:54:37Z

[Term]
id: GO:1900542
name: regulation of purine nucleotide metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of purine nucleotide metabolic process." [GOC:TermGenie]
synonym: "regulation of purine metabolic process" NARROW [GOC:TermGenie]
synonym: "regulation of purine metabolism" NARROW [GOC:TermGenie]
synonym: "regulation of purine nucleotide metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006140 ! regulation of nucleotide metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006163 ! purine nucleotide metabolic process
relationship: regulates GO:0006163 ! purine nucleotide metabolic process
created_by: krc
creation_date: 2012-05-11T05:43:15Z

[Term]
id: GO:1900543
name: negative regulation of purine nucleotide metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of purine nucleotide metabolic process." [GOC:TermGenie]
synonym: "down regulation of purine metabolic process" NARROW [GOC:TermGenie]
synonym: "down regulation of purine metabolism" NARROW [GOC:TermGenie]
synonym: "down regulation of purine nucleotide metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of purine nucleotide metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of purine metabolic process" NARROW [GOC:TermGenie]
synonym: "down-regulation of purine metabolism" NARROW [GOC:TermGenie]
synonym: "down-regulation of purine nucleotide metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of purine nucleotide metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of purine metabolic process" NARROW [GOC:TermGenie]
synonym: "downregulation of purine metabolism" NARROW [GOC:TermGenie]
synonym: "downregulation of purine nucleotide metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of purine nucleotide metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of purine metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of purine metabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of purine nucleotide metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of purine nucleotide metabolism" NARROW [GOC:TermGenie]
synonym: "negative regulation of purine metabolic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of purine metabolism" NARROW [GOC:TermGenie]
synonym: "negative regulation of purine nucleotide metabolism" EXACT [GOC:TermGenie]
is_a: GO:0045980 ! negative regulation of nucleotide metabolic process
is_a: GO:1900542 ! regulation of purine nucleotide metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006163 ! purine nucleotide metabolic process
relationship: negatively_regulates GO:0006163 ! purine nucleotide metabolic process
created_by: krc
creation_date: 2012-05-11T05:44:21Z

[Term]
id: GO:1900544
name: positive regulation of purine nucleotide metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of purine nucleotide metabolic process." [GOC:TermGenie]
synonym: "activation of purine metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of purine metabolism" NARROW [GOC:TermGenie]
synonym: "activation of purine nucleotide metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of purine nucleotide metabolism" NARROW [GOC:TermGenie]
synonym: "positive regulation of purine metabolic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of purine metabolism" NARROW [GOC:TermGenie]
synonym: "positive regulation of purine nucleotide metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of purine metabolic process" NARROW [GOC:TermGenie]
synonym: "up regulation of purine metabolism" NARROW [GOC:TermGenie]
synonym: "up regulation of purine nucleotide metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of purine nucleotide metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of purine metabolic process" NARROW [GOC:TermGenie]
synonym: "up-regulation of purine metabolism" NARROW [GOC:TermGenie]
synonym: "up-regulation of purine nucleotide metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of purine nucleotide metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of purine metabolic process" NARROW [GOC:TermGenie]
synonym: "upregulation of purine metabolism" NARROW [GOC:TermGenie]
synonym: "upregulation of purine nucleotide metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of purine nucleotide metabolism" EXACT [GOC:TermGenie]
is_a: GO:0045981 ! positive regulation of nucleotide metabolic process
is_a: GO:1900542 ! regulation of purine nucleotide metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006163 ! purine nucleotide metabolic process
relationship: positively_regulates GO:0006163 ! purine nucleotide metabolic process
created_by: krc
creation_date: 2012-05-11T05:44:43Z

[Term]
id: GO:1900545
name: regulation of phenotypic switching by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A regulation of transcription from RNA polymerase II promoter that results in regulation of phenotypic switching." [GOC:di, GOC:TermGenie]
synonym: "regulation of phenotypic dimorphism by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:1900239 ! regulation of phenotypic switching
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: regulates GO:0100057 ! regulation of phenotypic switching by transcription from RNA polymerase II promoter
relationship: regulates GO:0100057 ! regulation of phenotypic switching by transcription from RNA polymerase II promoter
created_by: di
creation_date: 2012-05-14T11:28:41Z

[Term]
id: GO:1900546
name: positive regulation of phenotypic switching by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A regulation of transcription from RNA polymerase II promoter that results in positive regulation of phenotypic switching." [GOC:di, GOC:TermGenie]
synonym: "activation of phenotypic dimorphism by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "activation of phenotypic switching by regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "positive regulation of phenotypic dimorphism by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "up regulation of phenotypic dimorphism by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "up regulation of phenotypic switching by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of phenotypic dimorphism by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "up-regulation of phenotypic switching by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of phenotypic dimorphism by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "upregulation of phenotypic switching by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_a: GO:1900241 ! positive regulation of phenotypic switching
is_a: GO:1900545 ! regulation of phenotypic switching by regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
intersection_of: positively_regulates GO:0036166 ! phenotypic switching
relationship: positively_regulates GO:0036166 ! phenotypic switching
created_by: di
creation_date: 2012-05-14T11:36:05Z

[Term]
id: GO:1900547
name: negative regulation of phenotypic switching by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A regulation of transcription from RNA polymerase II promoter that results in negative regulation of phenotypic switching." [GOC:di, GOC:TermGenie]
synonym: "negative regulation of phenotypic dimorphism by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
is_a: GO:1900240 ! negative regulation of phenotypic switching
is_a: GO:1900545 ! regulation of phenotypic switching by regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: regulates GO:0100059 ! negative regulation of phenotypic switching by transcription from RNA polymerase II promoter
relationship: regulates GO:0100059 ! negative regulation of phenotypic switching by transcription from RNA polymerase II promoter
created_by: di
creation_date: 2012-05-14T11:40:54Z

[Term]
id: GO:1900548
name: heme b catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of heme b, a Fe(II) porphyrin complex readily isolated from the hemoglobin of beef blood, but also found in other proteins including other hemoglobins, myoglobins, cytochromes P-450, catalases, peroxidases as well as b type cytochromes." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5874, UniPathway:UPA00684]
synonym: "heme b breakdown" EXACT [GOC:TermGenie]
synonym: "heme b catabolism" EXACT [GOC:TermGenie]
synonym: "heme b degradation" EXACT [GOC:TermGenie]
synonym: "protoheme catabolic process" EXACT []
synonym: "protoheme degradation" EXACT []
is_a: GO:0042167 ! heme catabolic process
is_a: GO:0046492 ! heme b metabolic process
created_by: pr
creation_date: 2012-05-14T12:35:18Z

[Term]
id: GO:1900549
name: N',N'',N'''-triacetylfusarinine C metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving N',N'',N'''-triacetylfusarinine C." [GOC:di, GOC:TermGenie]
synonym: "N',N'',N'''-triacetylfusarinine C metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process
created_by: di
creation_date: 2012-05-15T12:59:06Z

[Term]
id: GO:1900550
name: N',N'',N'''-triacetylfusarinine C catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of N',N'',N'''-triacetylfusarinine C." [GOC:di, GOC:TermGenie]
synonym: "N',N'',N'''-triacetylfusarinine C breakdown" EXACT [GOC:TermGenie]
synonym: "N',N'',N'''-triacetylfusarinine C catabolism" EXACT [GOC:TermGenie]
synonym: "N',N'',N'''-triacetylfusarinine C degradation" EXACT [GOC:TermGenie]
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900549 ! N',N'',N'''-triacetylfusarinine C metabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process
created_by: di
creation_date: 2012-05-15T01:00:07Z

[Term]
id: GO:1900551
name: N',N'',N'''-triacetylfusarinine C biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of N',N'',N'''-triacetylfusarinine C." [GOC:di, GOC:TermGenie]
synonym: "N',N'',N'''-triacetylfusarinine C anabolism" EXACT [GOC:TermGenie]
synonym: "N',N'',N'''-triacetylfusarinine C biosynthesis" EXACT [GOC:TermGenie]
synonym: "N',N'',N'''-triacetylfusarinine C formation" EXACT [GOC:TermGenie]
synonym: "N',N'',N'''-triacetylfusarinine C synthesis" EXACT [GOC:TermGenie]
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:1900549 ! N',N'',N'''-triacetylfusarinine C metabolic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process
created_by: di
creation_date: 2012-05-15T01:00:58Z

[Term]
id: GO:1900552
name: asperfuranone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving asperfuranone." [GOC:di, GOC:TermGenie]
synonym: "asperfuranone metabolism" EXACT [GOC:TermGenie]
is_a: GO:0030638 ! polyketide metabolic process
is_a: GO:0034311 ! diol metabolic process
is_a: GO:0042180 ! cellular ketone metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1902644 ! tertiary alcohol metabolic process
is_a: GO:1902652 ! secondary alcohol metabolic process
created_by: di
creation_date: 2012-05-15T01:30:48Z

[Term]
id: GO:1900553
name: asperfuranone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of asperfuranone." [GOC:di, GOC:TermGenie]
synonym: "asperfuranone breakdown" EXACT [GOC:TermGenie]
synonym: "asperfuranone catabolism" EXACT [GOC:TermGenie]
synonym: "asperfuranone degradation" EXACT [GOC:TermGenie]
is_a: GO:0030640 ! polyketide catabolic process
is_a: GO:0034313 ! diol catabolic process
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1900552 ! asperfuranone metabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
created_by: di
creation_date: 2012-05-15T01:31:35Z

[Term]
id: GO:1900554
name: asperfuranone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of asperfuranone." [GOC:di, GOC:TermGenie]
synonym: "asperfuranone anabolism" EXACT [GOC:TermGenie]
synonym: "asperfuranone biosynthesis" EXACT [GOC:TermGenie]
synonym: "asperfuranone formation" EXACT [GOC:TermGenie]
synonym: "asperfuranone synthesis" EXACT [GOC:TermGenie]
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0030639 ! polyketide biosynthetic process
is_a: GO:0034312 ! diol biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:1900552 ! asperfuranone metabolic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1902645 ! tertiary alcohol biosynthetic process
is_a: GO:1902653 ! secondary alcohol biosynthetic process
created_by: di
creation_date: 2012-05-15T01:31:58Z

[Term]
id: GO:1900555
name: emericellamide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving emericellamide." [GOC:di, GOC:TermGenie]
synonym: "emericellamide metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006629 ! lipid metabolic process
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0050761 ! depsipeptide metabolic process
is_a: GO:1901334 ! lactone metabolic process
created_by: di
creation_date: 2012-05-15T01:32:19Z

[Term]
id: GO:1900556
name: emericellamide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of emericellamide." [GOC:di, GOC:TermGenie]
synonym: "emericellamide breakdown" EXACT [GOC:TermGenie]
synonym: "emericellamide catabolism" EXACT [GOC:TermGenie]
synonym: "emericellamide degradation" EXACT [GOC:TermGenie]
is_a: GO:0016042 ! lipid catabolic process
is_a: GO:0050762 ! depsipeptide catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900555 ! emericellamide metabolic process
is_a: GO:1901335 ! lactone catabolic process
created_by: di
creation_date: 2012-05-15T01:33:07Z

[Term]
id: GO:1900557
name: emericellamide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of emericellamide." [GOC:di, GOC:TermGenie]
synonym: "emericellamide anabolism" EXACT [GOC:TermGenie]
synonym: "emericellamide biosynthesis" EXACT [GOC:TermGenie]
synonym: "emericellamide formation" EXACT [GOC:TermGenie]
synonym: "emericellamide synthesis" EXACT [GOC:TermGenie]
is_a: GO:0008610 ! lipid biosynthetic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:0050763 ! depsipeptide biosynthetic process
is_a: GO:1900555 ! emericellamide metabolic process
is_a: GO:1901336 ! lactone biosynthetic process
created_by: di
creation_date: 2012-05-15T01:33:31Z

[Term]
id: GO:1900558
name: austinol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving austinol." [GOC:di, GOC:TermGenie]
synonym: "austinol metabolism" EXACT [GOC:TermGenie]
is_a: GO:0044710 ! single-organism metabolic process
is_a: GO:0071704 ! organic substance metabolic process
created_by: di
creation_date: 2012-05-15T06:26:58Z

[Term]
id: GO:1900559
name: austinol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of austinol." [GOC:di, GOC:TermGenie]
synonym: "austinol breakdown" EXACT [GOC:TermGenie]
synonym: "austinol catabolism" EXACT [GOC:TermGenie]
synonym: "austinol degradation" EXACT [GOC:TermGenie]
is_a: GO:0044712 ! single-organism catabolic process
is_a: GO:1900558 ! austinol metabolic process
is_a: GO:1901575 ! organic substance catabolic process
created_by: di
creation_date: 2012-05-15T06:27:22Z

[Term]
id: GO:1900560
name: austinol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of austinol." [GOC:di, GOC:TermGenie]
synonym: "austinol anabolism" EXACT [GOC:TermGenie]
synonym: "austinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "austinol formation" EXACT [GOC:TermGenie]
synonym: "austinol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:1900558 ! austinol metabolic process
is_a: GO:1901576 ! organic substance biosynthetic process
created_by: di
creation_date: 2012-05-15T06:27:30Z

[Term]
id: GO:1900561
name: dehydroaustinol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dehydroaustinol." [GOC:di, GOC:TermGenie]
synonym: "dehydroaustinol metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0071704 ! organic substance metabolic process
created_by: di
creation_date: 2012-05-15T06:27:35Z

[Term]
id: GO:1900562
name: dehydroaustinol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dehydroaustinol." [GOC:di, GOC:TermGenie]
synonym: "dehydroaustinol breakdown" EXACT [GOC:TermGenie]
synonym: "dehydroaustinol catabolism" EXACT [GOC:TermGenie]
synonym: "dehydroaustinol degradation" EXACT [GOC:TermGenie]
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900561 ! dehydroaustinol metabolic process
is_a: GO:1901575 ! organic substance catabolic process
created_by: di
creation_date: 2012-05-15T06:27:55Z

[Term]
id: GO:1900563
name: dehydroaustinol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dehydroaustinol." [GOC:di, GOC:TermGenie]
synonym: "dehydroaustinol anabolism" EXACT [GOC:TermGenie]
synonym: "dehydroaustinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "dehydroaustinol formation" EXACT [GOC:TermGenie]
synonym: "dehydroaustinol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:1900561 ! dehydroaustinol metabolic process
is_a: GO:1901576 ! organic substance biosynthetic process
created_by: di
creation_date: 2012-05-15T06:28:03Z

[Term]
id: GO:1900564
name: chanoclavine-I metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving chanoclavine-I." [GOC:di, GOC:TermGenie]
synonym: "chanoclavine-I metabolism" EXACT [GOC:TermGenie]
is_a: GO:0034308 ! primary alcohol metabolic process
is_a: GO:0035836 ! ergot alkaloid metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:0097164 ! ammonium ion metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
created_by: di
creation_date: 2012-05-15T06:30:25Z

[Term]
id: GO:1900565
name: chanoclavine-I catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of chanoclavine-I." [GOC:di, GOC:TermGenie]
synonym: "chanoclavine-I breakdown" EXACT [GOC:TermGenie]
synonym: "chanoclavine-I catabolism" EXACT [GOC:TermGenie]
synonym: "chanoclavine-I degradation" EXACT [GOC:TermGenie]
is_a: GO:0034310 ! primary alcohol catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1900564 ! chanoclavine-I metabolic process
is_a: GO:1900806 ! ergot alkaloid catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
created_by: di
creation_date: 2012-05-15T06:30:48Z

[Term]
id: GO:1900566
name: chanoclavine-I biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of chanoclavine-I." [GOC:di, GOC:TermGenie]
synonym: "chanoclavine-I anabolism" EXACT [GOC:TermGenie]
synonym: "chanoclavine-I biosynthesis" EXACT [GOC:TermGenie]
synonym: "chanoclavine-I formation" EXACT [GOC:TermGenie]
synonym: "chanoclavine-I synthesis" EXACT [GOC:TermGenie]
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0034309 ! primary alcohol biosynthetic process
is_a: GO:0035837 ! ergot alkaloid biosynthetic process
is_a: GO:1900564 ! chanoclavine-I metabolic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
created_by: di
creation_date: 2012-05-15T06:30:55Z

[Term]
id: GO:1900567
name: chanoclavine-I aldehyde metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving chanoclavine-I aldehyde." [GOC:di, GOC:TermGenie]
synonym: "chanoclavine-I aldehyde metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006081 ! cellular aldehyde metabolic process
is_a: GO:0035836 ! ergot alkaloid metabolic process
is_a: GO:0097164 ! ammonium ion metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
created_by: di
creation_date: 2012-05-15T06:31:00Z

[Term]
id: GO:1900568
name: chanoclavine-I aldehyde catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of chanoclavine-I aldehyde." [GOC:di, GOC:TermGenie]
synonym: "chanoclavine-I aldehyde breakdown" EXACT [GOC:TermGenie]
synonym: "chanoclavine-I aldehyde catabolism" EXACT [GOC:TermGenie]
synonym: "chanoclavine-I aldehyde degradation" EXACT [GOC:TermGenie]
is_a: GO:0046185 ! aldehyde catabolic process
is_a: GO:1900567 ! chanoclavine-I aldehyde metabolic process
is_a: GO:1900806 ! ergot alkaloid catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
created_by: di
creation_date: 2012-05-15T06:31:21Z

[Term]
id: GO:1900569
name: chanoclavine-I aldehyde biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of chanoclavine-I aldehyde." [GOC:di, GOC:TermGenie]
synonym: "chanoclavine-I aldehyde anabolism" EXACT [GOC:TermGenie]
synonym: "chanoclavine-I aldehyde biosynthesis" EXACT [GOC:TermGenie]
synonym: "chanoclavine-I aldehyde formation" EXACT [GOC:TermGenie]
synonym: "chanoclavine-I aldehyde synthesis" EXACT [GOC:TermGenie]
is_a: GO:0035837 ! ergot alkaloid biosynthetic process
is_a: GO:0046184 ! aldehyde biosynthetic process
is_a: GO:1900567 ! chanoclavine-I aldehyde metabolic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
created_by: di
creation_date: 2012-05-15T06:31:28Z

[Term]
id: GO:1900570
name: diorcinol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving diorcinol." [GOC:di, GOC:TermGenie]
synonym: "diorcinol metabolism" EXACT [GOC:TermGenie]
is_a: GO:0018904 ! ether metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0044763 ! single-organism cellular process
created_by: di
creation_date: 2012-05-15T06:35:01Z

[Term]
id: GO:1900571
name: diorcinol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of diorcinol." [GOC:di, GOC:TermGenie]
synonym: "diorcinol breakdown" EXACT [GOC:TermGenie]
synonym: "diorcinol catabolism" EXACT [GOC:TermGenie]
synonym: "diorcinol degradation" EXACT [GOC:TermGenie]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900570 ! diorcinol metabolic process
is_a: GO:1901502 ! ether catabolic process
created_by: di
creation_date: 2012-05-15T06:35:22Z

[Term]
id: GO:1900572
name: diorcinol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of diorcinol." [GOC:di, GOC:TermGenie]
synonym: "diorcinol anabolism" EXACT [GOC:TermGenie]
synonym: "diorcinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "diorcinol formation" EXACT [GOC:TermGenie]
synonym: "diorcinol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:1900570 ! diorcinol metabolic process
is_a: GO:1901503 ! ether biosynthetic process
created_by: di
creation_date: 2012-05-15T06:35:29Z

[Term]
id: GO:1900573
name: emodin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving emodin." [GOC:di, GOC:TermGenie]
synonym: "emodin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:1901661 ! quinone metabolic process
created_by: di
creation_date: 2012-05-15T06:41:44Z

[Term]
id: GO:1900574
name: emodin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of emodin." [GOC:di, GOC:TermGenie]
synonym: "emodin breakdown" EXACT [GOC:TermGenie]
synonym: "emodin catabolism" EXACT [GOC:TermGenie]
synonym: "emodin degradation" EXACT [GOC:TermGenie]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900573 ! emodin metabolic process
is_a: GO:1901662 ! quinone catabolic process
created_by: di
creation_date: 2012-05-15T06:42:06Z

[Term]
id: GO:1900575
name: emodin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of emodin." [GOC:di, GOC:TermGenie]
synonym: "emodin anabolism" EXACT [GOC:TermGenie]
synonym: "emodin biosynthesis" EXACT [GOC:TermGenie]
synonym: "emodin formation" EXACT [GOC:TermGenie]
synonym: "emodin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:1900573 ! emodin metabolic process
is_a: GO:1901663 ! quinone biosynthetic process
created_by: di
creation_date: 2012-05-15T06:42:14Z

[Term]
id: GO:1900576
name: gerfelin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving gerfelin." [GOC:di, GOC:TermGenie]
synonym: "gerfelin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009712 ! catechol-containing compound metabolic process
is_a: GO:0018904 ! ether metabolic process
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process
created_by: di
creation_date: 2012-05-15T06:42:19Z

[Term]
id: GO:1900577
name: gerfelin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of gerfelin." [GOC:di, GOC:TermGenie]
synonym: "gerfelin breakdown" EXACT [GOC:TermGenie]
synonym: "gerfelin catabolism" EXACT [GOC:TermGenie]
synonym: "gerfelin degradation" EXACT [GOC:TermGenie]
is_a: GO:0019614 ! catechol-containing compound catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900576 ! gerfelin metabolic process
is_a: GO:1901502 ! ether catabolic process
created_by: di
creation_date: 2012-05-15T06:42:39Z

[Term]
id: GO:1900578
name: gerfelin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of gerfelin." [GOC:di, GOC:TermGenie]
synonym: "gerfelin anabolism" EXACT [GOC:TermGenie]
synonym: "gerfelin biosynthesis" EXACT [GOC:TermGenie]
synonym: "gerfelin formation" EXACT [GOC:TermGenie]
synonym: "gerfelin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009713 ! catechol-containing compound biosynthetic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:1900576 ! gerfelin metabolic process
is_a: GO:1901503 ! ether biosynthetic process
created_by: di
creation_date: 2012-05-15T06:42:47Z

[Term]
id: GO:1900579
name: (17Z)-protosta-17(20),24-dien-3beta-ol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (17Z)-protosta-17(20),24-dien-3beta-ol." [GOC:di, GOC:TermGenie]
synonym: "(17Z)-protosta-17(20),24-dien-3beta-ol metabolism" EXACT [GOC:TermGenie]
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:0010685 ! tetracyclic triterpenoid metabolic process
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:1902652 ! secondary alcohol metabolic process
created_by: di
creation_date: 2012-05-15T06:47:07Z

[Term]
id: GO:1900580
name: (17Z)-protosta-17(20),24-dien-3beta-ol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of (17Z)-protosta-17(20),24-dien-3beta-ol." [GOC:di, GOC:TermGenie]
synonym: "(17Z)-protosta-17(20),24-dien-3beta-ol breakdown" EXACT [GOC:TermGenie]
synonym: "(17Z)-protosta-17(20),24-dien-3beta-ol catabolism" EXACT [GOC:TermGenie]
synonym: "(17Z)-protosta-17(20),24-dien-3beta-ol degradation" EXACT [GOC:TermGenie]
is_a: GO:0006706 ! steroid catabolic process
is_a: GO:0016105 ! triterpenoid catabolic process
is_a: GO:0046164 ! alcohol catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900579 ! (17Z)-protosta-17(20),24-dien-3beta-ol metabolic process
created_by: di
creation_date: 2012-05-15T06:47:30Z

[Term]
id: GO:1900581
name: (17Z)-protosta-17(20),24-dien-3beta-ol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (17Z)-protosta-17(20),24-dien-3beta-ol." [GOC:di, GOC:TermGenie]
synonym: "(17Z)-protosta-17(20),24-dien-3beta-ol anabolism" EXACT [GOC:TermGenie]
synonym: "(17Z)-protosta-17(20),24-dien-3beta-ol biosynthesis" EXACT [GOC:TermGenie]
synonym: "(17Z)-protosta-17(20),24-dien-3beta-ol formation" EXACT [GOC:TermGenie]
synonym: "(17Z)-protosta-17(20),24-dien-3beta-ol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0006694 ! steroid biosynthetic process
is_a: GO:0010686 ! tetracyclic triterpenoid biosynthetic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:1900579 ! (17Z)-protosta-17(20),24-dien-3beta-ol metabolic process
is_a: GO:1902653 ! secondary alcohol biosynthetic process
created_by: di
creation_date: 2012-05-15T06:47:38Z

[Term]
id: GO:1900582
name: o-orsellinic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving o-orsellinic acid." [GOC:di, GOC:TermGenie]
synonym: "o-orsellinic acid metabolism" EXACT [GOC:TermGenie]
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process
created_by: di
creation_date: 2012-05-15T06:47:42Z

[Term]
id: GO:1900583
name: o-orsellinic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of o-orsellinic acid." [GOC:di, GOC:TermGenie]
synonym: "o-orsellinic acid breakdown" EXACT [GOC:TermGenie]
synonym: "o-orsellinic acid catabolism" EXACT [GOC:TermGenie]
synonym: "o-orsellinic acid degradation" EXACT [GOC:TermGenie]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900582 ! o-orsellinic acid metabolic process
created_by: di
creation_date: 2012-05-15T06:48:04Z

[Term]
id: GO:1900584
name: o-orsellinic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of o-orsellinic acid." [GOC:di, GOC:TermGenie]
synonym: "o-orsellinic acid anabolism" EXACT [GOC:TermGenie]
synonym: "o-orsellinic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "o-orsellinic acid formation" EXACT [GOC:TermGenie]
synonym: "o-orsellinic acid synthesis" EXACT [GOC:TermGenie]
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:1900582 ! o-orsellinic acid metabolic process
created_by: di
creation_date: 2012-05-15T06:48:11Z

[Term]
id: GO:1900585
name: arugosin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving arugosin." [GOC:di, GOC:TermGenie]
synonym: "arugosin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0071704 ! organic substance metabolic process
created_by: di
creation_date: 2012-05-15T06:48:15Z

[Term]
id: GO:1900586
name: arugosin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of arugosin." [GOC:di, GOC:TermGenie]
synonym: "arugosin breakdown" EXACT [GOC:TermGenie]
synonym: "arugosin catabolism" EXACT [GOC:TermGenie]
synonym: "arugosin degradation" EXACT [GOC:TermGenie]
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900585 ! arugosin metabolic process
is_a: GO:1901575 ! organic substance catabolic process
created_by: di
creation_date: 2012-05-15T06:48:37Z

[Term]
id: GO:1900587
name: arugosin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of arugosin." [GOC:di, GOC:TermGenie]
synonym: "arugosin anabolism" EXACT [GOC:TermGenie]
synonym: "arugosin biosynthesis" EXACT [GOC:TermGenie]
synonym: "arugosin formation" EXACT [GOC:TermGenie]
synonym: "arugosin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:1900585 ! arugosin metabolic process
is_a: GO:1901576 ! organic substance biosynthetic process
created_by: di
creation_date: 2012-05-15T06:48:45Z

[Term]
id: GO:1900588
name: violaceol I metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving violaceol I." [GOC:di, GOC:TermGenie]
synonym: "violaceol I metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009712 ! catechol-containing compound metabolic process
is_a: GO:0018904 ! ether metabolic process
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0044763 ! single-organism cellular process
created_by: di
creation_date: 2012-05-15T06:50:48Z

[Term]
id: GO:1900589
name: violaceol I catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of violaceol I." [GOC:di, GOC:TermGenie]
synonym: "violaceol I breakdown" EXACT [GOC:TermGenie]
synonym: "violaceol I catabolism" EXACT [GOC:TermGenie]
synonym: "violaceol I degradation" EXACT [GOC:TermGenie]
is_a: GO:0019614 ! catechol-containing compound catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900588 ! violaceol I metabolic process
is_a: GO:1901502 ! ether catabolic process
created_by: di
creation_date: 2012-05-15T06:51:09Z

[Term]
id: GO:1900590
name: violaceol I biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of violaceol I." [GOC:di, GOC:TermGenie]
synonym: "violaceol I anabolism" EXACT [GOC:TermGenie]
synonym: "violaceol I biosynthesis" EXACT [GOC:TermGenie]
synonym: "violaceol I formation" EXACT [GOC:TermGenie]
synonym: "violaceol I synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009713 ! catechol-containing compound biosynthetic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:1900588 ! violaceol I metabolic process
is_a: GO:1901503 ! ether biosynthetic process
created_by: di
creation_date: 2012-05-15T06:51:16Z

[Term]
id: GO:1900591
name: violaceol II metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving violaceol II." [GOC:di, GOC:TermGenie]
synonym: "violaceol II metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009712 ! catechol-containing compound metabolic process
is_a: GO:0018904 ! ether metabolic process
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0044763 ! single-organism cellular process
created_by: di
creation_date: 2012-05-15T06:51:21Z

[Term]
id: GO:1900592
name: violaceol II catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of violaceol II." [GOC:di, GOC:TermGenie]
synonym: "violaceol II breakdown" EXACT [GOC:TermGenie]
synonym: "violaceol II catabolism" EXACT [GOC:TermGenie]
synonym: "violaceol II degradation" EXACT [GOC:TermGenie]
is_a: GO:0019614 ! catechol-containing compound catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900591 ! violaceol II metabolic process
is_a: GO:1901502 ! ether catabolic process
created_by: di
creation_date: 2012-05-15T06:51:43Z

[Term]
id: GO:1900593
name: violaceol II biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of violaceol II." [GOC:di, GOC:TermGenie]
synonym: "violaceol II anabolism" EXACT [GOC:TermGenie]
synonym: "violaceol II biosynthesis" EXACT [GOC:TermGenie]
synonym: "violaceol II formation" EXACT [GOC:TermGenie]
synonym: "violaceol II synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009713 ! catechol-containing compound biosynthetic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:1900591 ! violaceol II metabolic process
is_a: GO:1901503 ! ether biosynthetic process
created_by: di
creation_date: 2012-05-15T06:51:51Z

[Term]
id: GO:1900594
name: (+)-kotanin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (+)-kotanin." [GOC:di, GOC:TermGenie]
synonym: "(+)-kotanin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
created_by: di
creation_date: 2012-05-15T06:54:19Z

[Term]
id: GO:1900595
name: (+)-kotanin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of (+)-kotanin." [GOC:di, GOC:TermGenie]
synonym: "(+)-kotanin breakdown" EXACT [GOC:TermGenie]
synonym: "(+)-kotanin catabolism" EXACT [GOC:TermGenie]
synonym: "(+)-kotanin degradation" EXACT [GOC:TermGenie]
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900594 ! (+)-kotanin metabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
created_by: di
creation_date: 2012-05-15T06:54:40Z

[Term]
id: GO:1900596
name: (+)-kotanin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (+)-kotanin." [GOC:di, GOC:TermGenie]
synonym: "(+)-kotanin anabolism" EXACT [GOC:TermGenie]
synonym: "(+)-kotanin biosynthesis" EXACT [GOC:TermGenie]
synonym: "(+)-kotanin formation" EXACT [GOC:TermGenie]
synonym: "(+)-kotanin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:1900594 ! (+)-kotanin metabolic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
created_by: di
creation_date: 2012-05-15T06:54:47Z

[Term]
id: GO:1900597
name: demethylkotanin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving demethylkotanin." [GOC:di, GOC:TermGenie]
synonym: "demethylkotanin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
created_by: di
creation_date: 2012-05-15T06:54:52Z

[Term]
id: GO:1900598
name: demethylkotanin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of demethylkotanin." [GOC:di, GOC:TermGenie]
synonym: "demethylkotanin breakdown" EXACT [GOC:TermGenie]
synonym: "demethylkotanin catabolism" EXACT [GOC:TermGenie]
synonym: "demethylkotanin degradation" EXACT [GOC:TermGenie]
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900597 ! demethylkotanin metabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
created_by: di
creation_date: 2012-05-15T06:55:14Z

[Term]
id: GO:1900599
name: demethylkotanin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of demethylkotanin." [GOC:di, GOC:TermGenie]
synonym: "demethylkotanin anabolism" EXACT [GOC:TermGenie]
synonym: "demethylkotanin biosynthesis" EXACT [GOC:TermGenie]
synonym: "demethylkotanin formation" EXACT [GOC:TermGenie]
synonym: "demethylkotanin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:1900597 ! demethylkotanin metabolic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
created_by: di
creation_date: 2012-05-15T06:55:21Z

[Term]
id: GO:1900600
name: endocrocin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving endocrocin." [GOC:di, GOC:TermGenie]
synonym: "endocrocin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:1901661 ! quinone metabolic process
created_by: di
creation_date: 2012-05-15T06:57:14Z

[Term]
id: GO:1900601
name: endocrocin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of endocrocin." [GOC:di, GOC:TermGenie]
synonym: "endocrocin breakdown" EXACT [GOC:TermGenie]
synonym: "endocrocin catabolism" EXACT [GOC:TermGenie]
synonym: "endocrocin degradation" EXACT [GOC:TermGenie]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900600 ! endocrocin metabolic process
is_a: GO:1901662 ! quinone catabolic process
created_by: di
creation_date: 2012-05-15T06:57:34Z

[Term]
id: GO:1900602
name: endocrocin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of endocrocin." [GOC:di, GOC:TermGenie]
synonym: "endocrocin anabolism" EXACT [GOC:TermGenie]
synonym: "endocrocin biosynthesis" EXACT [GOC:TermGenie]
synonym: "endocrocin formation" EXACT [GOC:TermGenie]
synonym: "endocrocin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:1900600 ! endocrocin metabolic process
is_a: GO:1901663 ! quinone biosynthetic process
created_by: di
creation_date: 2012-05-15T06:57:42Z

[Term]
id: GO:1900603
name: tensidol A metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tensidol A." [GOC:di, GOC:TermGenie]
synonym: "tensidol A metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process
created_by: di
creation_date: 2012-05-15T06:57:47Z

[Term]
id: GO:1900604
name: tensidol A catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tensidol A." [GOC:di, GOC:TermGenie]
synonym: "tensidol A breakdown" EXACT [GOC:TermGenie]
synonym: "tensidol A catabolism" EXACT [GOC:TermGenie]
synonym: "tensidol A degradation" EXACT [GOC:TermGenie]
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900603 ! tensidol A metabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process
created_by: di
creation_date: 2012-05-15T06:58:09Z

[Term]
id: GO:1900605
name: tensidol A biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tensidol A." [GOC:di, GOC:TermGenie]
synonym: "tensidol A anabolism" EXACT [GOC:TermGenie]
synonym: "tensidol A biosynthesis" EXACT [GOC:TermGenie]
synonym: "tensidol A formation" EXACT [GOC:TermGenie]
synonym: "tensidol A synthesis" EXACT [GOC:TermGenie]
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:1900603 ! tensidol A metabolic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process
created_by: di
creation_date: 2012-05-15T06:58:16Z

[Term]
id: GO:1900606
name: tensidol B metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tensidol B." [GOC:di, GOC:TermGenie]
synonym: "tensidol B metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process
created_by: di
creation_date: 2012-05-15T06:58:21Z

[Term]
id: GO:1900607
name: tensidol B catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tensidol B." [GOC:di, GOC:TermGenie]
synonym: "tensidol B breakdown" EXACT [GOC:TermGenie]
synonym: "tensidol B catabolism" EXACT [GOC:TermGenie]
synonym: "tensidol B degradation" EXACT [GOC:TermGenie]
is_a: GO:0046395 ! carboxylic acid catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900606 ! tensidol B metabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process
created_by: di
creation_date: 2012-05-15T06:58:43Z

[Term]
id: GO:1900608
name: tensidol B biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tensidol B." [GOC:di, GOC:TermGenie]
synonym: "tensidol B anabolism" EXACT [GOC:TermGenie]
synonym: "tensidol B biosynthesis" EXACT [GOC:TermGenie]
synonym: "tensidol B formation" EXACT [GOC:TermGenie]
synonym: "tensidol B synthesis" EXACT [GOC:TermGenie]
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
is_a: GO:1900606 ! tensidol B metabolic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process
created_by: di
creation_date: 2012-05-15T06:58:51Z

[Term]
id: GO:1900609
name: F-9775A metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving F-9775A." [GOC:di, GOC:TermGenie]
synonym: "F-9775A metabolism" EXACT [GOC:TermGenie]
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0030638 ! polyketide metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:1901376 ! organic heteropentacyclic compound metabolic process
created_by: di
creation_date: 2012-05-15T07:02:27Z

[Term]
id: GO:1900610
name: F-9775A catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of F-9775A." [GOC:di, GOC:TermGenie]
synonym: "F-9775A breakdown" EXACT [GOC:TermGenie]
synonym: "F-9775A catabolism" EXACT [GOC:TermGenie]
synonym: "F-9775A degradation" EXACT [GOC:TermGenie]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0030640 ! polyketide catabolic process
is_a: GO:1900609 ! F-9775A metabolic process
is_a: GO:1901377 ! organic heteropentacyclic compound catabolic process
created_by: di
creation_date: 2012-05-15T07:02:49Z

[Term]
id: GO:1900611
name: F-9775A biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of F-9775A." [GOC:di, GOC:TermGenie]
synonym: "F-9775A anabolism" EXACT [GOC:TermGenie]
synonym: "F-9775A biosynthesis" EXACT [GOC:TermGenie]
synonym: "F-9775A formation" EXACT [GOC:TermGenie]
synonym: "F-9775A synthesis" EXACT [GOC:TermGenie]
is_a: GO:0030639 ! polyketide biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:1900609 ! F-9775A metabolic process
is_a: GO:1901378 ! organic heteropentacyclic compound biosynthetic process
created_by: di
creation_date: 2012-05-15T07:02:56Z

[Term]
id: GO:1900612
name: F-9775B metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving F-9775B." [GOC:di, GOC:TermGenie]
synonym: "F-9775B metabolism" EXACT [GOC:TermGenie]
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0030638 ! polyketide metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:1901376 ! organic heteropentacyclic compound metabolic process
created_by: di
creation_date: 2012-05-15T07:03:01Z

[Term]
id: GO:1900613
name: F-9775B catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of F-9775B." [GOC:di, GOC:TermGenie]
synonym: "F-9775B breakdown" EXACT [GOC:TermGenie]
synonym: "F-9775B catabolism" EXACT [GOC:TermGenie]
synonym: "F-9775B degradation" EXACT [GOC:TermGenie]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0030640 ! polyketide catabolic process
is_a: GO:1900612 ! F-9775B metabolic process
is_a: GO:1901377 ! organic heteropentacyclic compound catabolic process
created_by: di
creation_date: 2012-05-15T07:03:24Z

[Term]
id: GO:1900614
name: F-9775B biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of F-9775B." [GOC:di, GOC:TermGenie]
synonym: "F-9775B anabolism" EXACT [GOC:TermGenie]
synonym: "F-9775B biosynthesis" EXACT [GOC:TermGenie]
synonym: "F-9775B formation" EXACT [GOC:TermGenie]
synonym: "F-9775B synthesis" EXACT [GOC:TermGenie]
is_a: GO:0030639 ! polyketide biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:1900612 ! F-9775B metabolic process
is_a: GO:1901378 ! organic heteropentacyclic compound biosynthetic process
created_by: di
creation_date: 2012-05-15T07:03:32Z

[Term]
id: GO:1900615
name: emericellamide A metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving emericellamide A." [GOC:di, GOC:TermGenie]
synonym: "emericellamide A metabolism" EXACT [GOC:TermGenie]
is_a: GO:1900555 ! emericellamide metabolic process
created_by: di
creation_date: 2012-05-15T07:59:59Z

[Term]
id: GO:1900616
name: emericellamide A catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of emericellamide A." [GOC:di, GOC:TermGenie]
synonym: "emericellamide A breakdown" EXACT [GOC:TermGenie]
synonym: "emericellamide A catabolism" EXACT [GOC:TermGenie]
synonym: "emericellamide A degradation" EXACT [GOC:TermGenie]
is_a: GO:1900556 ! emericellamide catabolic process
is_a: GO:1900615 ! emericellamide A metabolic process
created_by: di
creation_date: 2012-05-15T08:00:19Z

[Term]
id: GO:1900617
name: emericellamide A biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of emericellamide A." [GOC:di, GOC:TermGenie]
synonym: "emericellamide A anabolism" EXACT [GOC:TermGenie]
synonym: "emericellamide A biosynthesis" EXACT [GOC:TermGenie]
synonym: "emericellamide A formation" EXACT [GOC:TermGenie]
synonym: "emericellamide A synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900557 ! emericellamide biosynthetic process
is_a: GO:1900615 ! emericellamide A metabolic process
created_by: di
creation_date: 2012-05-15T08:00:27Z

[Term]
id: GO:1900618
name: regulation of shoot system morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of shoot morphogenesis." [GOC:TermGenie]
synonym: "regulation of shoot morphogenesis" EXACT []
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0048831 ! regulation of shoot system development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010016 ! shoot system morphogenesis
relationship: regulates GO:0010016 ! shoot system morphogenesis
created_by: tb
creation_date: 2012-05-15T09:24:37Z

[Term]
id: GO:1900619
name: acetate ester metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an acetate ester, any carboxylic ester where the carboxylic acid component is acetic acid." [GOC:TermGenie]
synonym: "acetate ester metabolism" EXACT [GOC:TermGenie]
synonym: "acetyl ester metabolic process" EXACT [CHEBI:47622]
synonym: "acetyl ester metabolism" EXACT [CHEBI:47622]
is_a: GO:0044710 ! single-organism metabolic process
is_a: GO:0071704 ! organic substance metabolic process
created_by: bf
creation_date: 2012-05-16T12:29:51Z

[Term]
id: GO:1900620
name: acetate ester biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an acetate esteran acetate ester, any carboxylic ester where the carboxylic acid component is acetic acid." [GOC:TermGenie, PMID:15042596]
synonym: "acetate ester anabolism" EXACT [GOC:TermGenie]
synonym: "acetate ester biosynthesis" EXACT [GOC:TermGenie]
synonym: "acetate ester formation" EXACT [GOC:TermGenie]
synonym: "acetate ester synthesis" EXACT [GOC:TermGenie]
synonym: "acetyl ester biosynthesis" EXACT [CHEBI:47622]
synonym: "acetyl ester biosynthetic process" EXACT [CHEBI:47622]
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:1900619 ! acetate ester metabolic process
is_a: GO:1901576 ! organic substance biosynthetic process
created_by: bf
creation_date: 2012-05-16T12:30:12Z

[Term]
id: GO:1900621
name: regulation of transcription from RNA polymerase II promoter by calcium-mediated signaling
namespace: biological_process
def: "Calcium-mediated signaling that results in regulation of transcription from an RNA polymerase II promoter." [GOC:BHF, GOC:TermGenie]
synonym: "regulation of gene-specific transcription from RNA polymerase II promoter by calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "regulation of global transcription from Pol II promoter by calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "regulation of transcription from Pol II promoter by calcium-mediated signaling" EXACT [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter, global by calcium-mediated signaling" RELATED [GOC:TermGenie]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0019722 ! calcium-mediated signaling
intersection_of: GO:0019722 ! calcium-mediated signaling
intersection_of: regulates GO:0006366 ! transcription from RNA polymerase II promoter
relationship: regulates GO:0006366 ! transcription from RNA polymerase II promoter
created_by: bf
creation_date: 2012-05-18T01:00:39Z

[Term]
id: GO:1900622
name: positive regulation of transcription from RNA polymerase II promoter by calcium-mediated signaling
namespace: biological_process
def: "Calcium-mediated signaling that results in positive regulation of transcription from an RNA polymerase II promoter." [GOC:bf, GOC:BHF, GOC:dgf, GOC:TermGenie, PMID:9407035, PMID:9407036]
synonym: "activation of global transcription from RNA polymerase II promoter by calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase II promoter by calcium-mediated signaling" EXACT [GOC:TermGenie]
synonym: "calcineurin-dependent transcription activation" NARROW [PMID:9407036]
synonym: "calcineurin-dependent transcriptional induction" NARROW [PMID:9407035]
synonym: "calcineurin-mediated activation of transcription" NARROW [PMID:9407035]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter by calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription from Pol II promoter by calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "positive regulation of transcription from Pol II promoter by calcium-mediated signaling" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription from RNA polymerase II promoter, global by calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "stimulation of global transcription from RNA polymerase II promoter by calcium-mediated signaling" NARROW [GOC:TermGenie]
synonym: "stimulation of transcription from RNA polymerase II promoter by calcium-mediated signaling" EXACT [GOC:TermGenie]
synonym: "up regulation of global transcription from RNA polymerase II promoter by calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase II promoter by calcium-mediated signaling" EXACT [GOC:TermGenie]
synonym: "up-regulation of global transcription from RNA polymerase II promoter by calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase II promoter by calcium-mediated signaling" EXACT [GOC:TermGenie]
synonym: "upregulation of global transcription from RNA polymerase II promoter by calcium-mediated signaling" RELATED [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase II promoter by calcium-mediated signaling" EXACT [GOC:TermGenie]
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
is_a: GO:1900621 ! regulation of transcription from RNA polymerase II promoter by calcium-mediated signaling
intersection_of: GO:0019722 ! calcium-mediated signaling
intersection_of: positively_regulates GO:0006366 ! transcription from RNA polymerase II promoter
relationship: positively_regulates GO:0006366 ! transcription from RNA polymerase II promoter
created_by: bf
creation_date: 2012-05-18T01:01:04Z

[Term]
id: GO:1900623
name: regulation of monocyte aggregation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of monocyte aggregation." [GOC:BHF, GOC:TermGenie]
synonym: "regulation of mononuclear phagocyte aggregation" EXACT [GOC:TermGenie]
is_a: GO:0034110 ! regulation of homotypic cell-cell adhesion
is_a: GO:1903037 ! regulation of leukocyte cell-cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070487 ! monocyte aggregation
relationship: regulates GO:0070487 ! monocyte aggregation
created_by: vk
creation_date: 2012-05-21T01:07:17Z

[Term]
id: GO:1900624
name: negative regulation of monocyte aggregation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of monocyte aggregation." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of monocyte aggregation" EXACT [GOC:TermGenie]
synonym: "down regulation of mononuclear phagocyte aggregation" EXACT [GOC:TermGenie]
synonym: "down-regulation of monocyte aggregation" EXACT [GOC:TermGenie]
synonym: "down-regulation of mononuclear phagocyte aggregation" EXACT [GOC:TermGenie]
synonym: "downregulation of monocyte aggregation" EXACT [GOC:TermGenie]
synonym: "downregulation of mononuclear phagocyte aggregation" EXACT [GOC:TermGenie]
synonym: "inhibition of monocyte aggregation" NARROW [GOC:TermGenie]
synonym: "inhibition of mononuclear phagocyte aggregation" EXACT [GOC:TermGenie]
synonym: "negative regulation of mononuclear phagocyte aggregation" EXACT [GOC:TermGenie]
is_a: GO:0034111 ! negative regulation of homotypic cell-cell adhesion
is_a: GO:1900623 ! regulation of monocyte aggregation
is_a: GO:1903038 ! negative regulation of leukocyte cell-cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070487 ! monocyte aggregation
relationship: negatively_regulates GO:0070487 ! monocyte aggregation
created_by: vk
creation_date: 2012-05-21T01:07:37Z

[Term]
id: GO:1900625
name: positive regulation of monocyte aggregation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of monocyte aggregation." [GOC:BHF, GOC:TermGenie]
synonym: "activation of monocyte aggregation" NARROW [GOC:TermGenie]
synonym: "activation of mononuclear phagocyte aggregation" EXACT [GOC:TermGenie]
synonym: "positive regulation of mononuclear phagocyte aggregation" EXACT [GOC:TermGenie]
synonym: "up regulation of monocyte aggregation" EXACT [GOC:TermGenie]
synonym: "up regulation of mononuclear phagocyte aggregation" EXACT [GOC:TermGenie]
synonym: "up-regulation of monocyte aggregation" EXACT [GOC:TermGenie]
synonym: "up-regulation of mononuclear phagocyte aggregation" EXACT [GOC:TermGenie]
synonym: "upregulation of monocyte aggregation" EXACT [GOC:TermGenie]
synonym: "upregulation of mononuclear phagocyte aggregation" EXACT [GOC:TermGenie]
is_a: GO:0034112 ! positive regulation of homotypic cell-cell adhesion
is_a: GO:1900623 ! regulation of monocyte aggregation
is_a: GO:1903039 ! positive regulation of leukocyte cell-cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070487 ! monocyte aggregation
relationship: positively_regulates GO:0070487 ! monocyte aggregation
created_by: vk
creation_date: 2012-05-21T01:07:44Z

[Term]
id: GO:1900626
name: regulation of arugosin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of arugosin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of arugosin anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of arugosin biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of arugosin formation" EXACT [GOC:TermGenie]
synonym: "regulation of arugosin synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900587 ! arugosin biosynthetic process
relationship: regulates GO:1900587 ! arugosin biosynthetic process
created_by: di
creation_date: 2012-05-21T05:47:39Z

[Term]
id: GO:1900627
name: negative regulation of arugosin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of arugosin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of arugosin anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of arugosin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of arugosin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of arugosin formation" EXACT [GOC:TermGenie]
synonym: "down regulation of arugosin synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of arugosin anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of arugosin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of arugosin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of arugosin formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of arugosin synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of arugosin anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of arugosin biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of arugosin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of arugosin formation" EXACT [GOC:TermGenie]
synonym: "downregulation of arugosin synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of arugosin anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of arugosin biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of arugosin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of arugosin formation" EXACT [GOC:TermGenie]
synonym: "inhibition of arugosin synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of arugosin anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of arugosin biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of arugosin formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of arugosin synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900626 ! regulation of arugosin biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900587 ! arugosin biosynthetic process
relationship: negatively_regulates GO:1900587 ! arugosin biosynthetic process
created_by: di
creation_date: 2012-05-21T05:48:03Z

[Term]
id: GO:1900628
name: positive regulation of arugosin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of arugosin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of arugosin anabolism" EXACT [GOC:TermGenie]
synonym: "activation of arugosin biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of arugosin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of arugosin formation" EXACT [GOC:TermGenie]
synonym: "activation of arugosin synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of arugosin anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of arugosin biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of arugosin formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of arugosin synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of arugosin anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of arugosin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of arugosin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of arugosin formation" EXACT [GOC:TermGenie]
synonym: "up regulation of arugosin synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of arugosin anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of arugosin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of arugosin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of arugosin formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of arugosin synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of arugosin anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of arugosin biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of arugosin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of arugosin formation" EXACT [GOC:TermGenie]
synonym: "upregulation of arugosin synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900626 ! regulation of arugosin biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900587 ! arugosin biosynthetic process
relationship: positively_regulates GO:1900587 ! arugosin biosynthetic process
created_by: di
creation_date: 2012-05-21T05:48:11Z

[Term]
id: GO:1900629
name: methanophenazine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving methanophenazine." [GOC:mengo_curators, GOC:TermGenie]
synonym: "methanophenazine metabolism" EXACT [GOC:TermGenie]
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process
created_by: tt
creation_date: 2012-05-21T06:12:07Z

[Term]
id: GO:1900630
name: methanophenazine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of methanophenazine." [GOC:mengo_curators, GOC:TermGenie]
synonym: "methanophenazine anabolism" EXACT [GOC:TermGenie]
synonym: "methanophenazine biosynthesis" EXACT [GOC:TermGenie]
synonym: "methanophenazine formation" EXACT [GOC:TermGenie]
synonym: "methanophenazine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:1900629 ! methanophenazine metabolic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process
created_by: tt
creation_date: 2012-05-21T06:12:30Z

[Term]
id: GO:1900631
name: tridecane metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tridecane." [GOC:mengo_curators, GOC:TermGenie]
synonym: "tridecane metabolism" EXACT [GOC:TermGenie]
is_a: GO:0043446 ! cellular alkane metabolic process
created_by: tt
creation_date: 2012-05-21T06:41:16Z

[Term]
id: GO:1900632
name: tridecane biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tridecane." [GOC:mengo_curators, GOC:TermGenie]
synonym: "tridecane anabolism" EXACT [GOC:TermGenie]
synonym: "tridecane biosynthesis" EXACT [GOC:TermGenie]
synonym: "tridecane formation" EXACT [GOC:TermGenie]
synonym: "tridecane synthesis" EXACT [GOC:TermGenie]
is_a: GO:0043447 ! alkane biosynthetic process
is_a: GO:1900631 ! tridecane metabolic process
created_by: tt
creation_date: 2012-05-21T06:41:37Z

[Term]
id: GO:1900633
name: pentadecane metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pentadecane." [GOC:mengo_curators, GOC:TermGenie]
synonym: "pentadecane metabolism" EXACT [GOC:TermGenie]
is_a: GO:0043446 ! cellular alkane metabolic process
created_by: tt
creation_date: 2012-05-21T06:51:34Z

[Term]
id: GO:1900634
name: pentadecane biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pentadecane." [GOC:mengo_curators, GOC:TermGenie]
synonym: "pentadecane anabolism" EXACT [GOC:TermGenie]
synonym: "pentadecane biosynthesis" EXACT [GOC:TermGenie]
synonym: "pentadecane formation" EXACT [GOC:TermGenie]
synonym: "pentadecane synthesis" EXACT [GOC:TermGenie]
is_a: GO:0043447 ! alkane biosynthetic process
is_a: GO:1900633 ! pentadecane metabolic process
created_by: tt
creation_date: 2012-05-21T06:51:57Z

[Term]
id: GO:1900635
name: heptadecane metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving heptadecane." [GOC:mengo_curators, GOC:TermGenie]
synonym: "heptadecane metabolism" EXACT [GOC:TermGenie]
is_a: GO:0043446 ! cellular alkane metabolic process
created_by: tt
creation_date: 2012-05-21T07:05:01Z

[Term]
id: GO:1900636
name: heptadecane biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of heptadecane." [GOC:mengo_curators, GOC:TermGenie]
synonym: "heptadecane anabolism" EXACT [GOC:TermGenie]
synonym: "heptadecane biosynthesis" EXACT [GOC:TermGenie]
synonym: "heptadecane formation" EXACT [GOC:TermGenie]
synonym: "heptadecane synthesis" EXACT [GOC:TermGenie]
is_a: GO:0043447 ! alkane biosynthetic process
is_a: GO:1900635 ! heptadecane metabolic process
created_by: tt
creation_date: 2012-05-21T07:05:21Z

[Term]
id: GO:1900637
name: regulation of asperfuranone biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of asperfuranone biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of asperfuranone anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of asperfuranone biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of asperfuranone formation" EXACT [GOC:TermGenie]
synonym: "regulation of asperfuranone synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900732 ! regulation of polyketide biosynthetic process
is_a: GO:1902930 ! regulation of alcohol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900554 ! asperfuranone biosynthetic process
relationship: regulates GO:1900554 ! asperfuranone biosynthetic process
created_by: di
creation_date: 2012-05-22T03:49:55Z

[Term]
id: GO:1900638
name: negative regulation of asperfuranone biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of asperfuranone biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of asperfuranone anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of asperfuranone biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of asperfuranone biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of asperfuranone formation" EXACT [GOC:TermGenie]
synonym: "down regulation of asperfuranone synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of asperfuranone anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of asperfuranone biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of asperfuranone biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of asperfuranone formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of asperfuranone synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of asperfuranone anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of asperfuranone biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of asperfuranone biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of asperfuranone formation" EXACT [GOC:TermGenie]
synonym: "downregulation of asperfuranone synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of asperfuranone anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of asperfuranone biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of asperfuranone biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of asperfuranone formation" EXACT [GOC:TermGenie]
synonym: "inhibition of asperfuranone synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of asperfuranone anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of asperfuranone biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of asperfuranone formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of asperfuranone synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900637 ! regulation of asperfuranone biosynthetic process
is_a: GO:1900733 ! negative regulation of polyketide biosynthetic process
is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900554 ! asperfuranone biosynthetic process
relationship: negatively_regulates GO:1900554 ! asperfuranone biosynthetic process
created_by: di
creation_date: 2012-05-22T03:50:16Z

[Term]
id: GO:1900639
name: positive regulation of asperfuranone biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of asperfuranone biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of asperfuranone anabolism" EXACT [GOC:TermGenie]
synonym: "activation of asperfuranone biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of asperfuranone biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of asperfuranone formation" EXACT [GOC:TermGenie]
synonym: "activation of asperfuranone synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of asperfuranone anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of asperfuranone biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of asperfuranone formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of asperfuranone synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of asperfuranone anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of asperfuranone biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of asperfuranone biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of asperfuranone formation" EXACT [GOC:TermGenie]
synonym: "up regulation of asperfuranone synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of asperfuranone anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of asperfuranone biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of asperfuranone biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of asperfuranone formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of asperfuranone synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of asperfuranone anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of asperfuranone biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of asperfuranone biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of asperfuranone formation" EXACT [GOC:TermGenie]
synonym: "upregulation of asperfuranone synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900637 ! regulation of asperfuranone biosynthetic process
is_a: GO:1900734 ! positive regulation of polyketide biosynthetic process
is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900554 ! asperfuranone biosynthetic process
relationship: positively_regulates GO:1900554 ! asperfuranone biosynthetic process
created_by: di
creation_date: 2012-05-22T03:50:24Z

[Term]
id: GO:1900640
name: regulation of austinol biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of austinol biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of austinol anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of austinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of austinol formation" EXACT [GOC:TermGenie]
synonym: "regulation of austinol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009889 ! regulation of biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900560 ! austinol biosynthetic process
relationship: regulates GO:1900560 ! austinol biosynthetic process
created_by: di
creation_date: 2012-05-22T03:57:33Z

[Term]
id: GO:1900641
name: negative regulation of austinol biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of austinol biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of austinol anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of austinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of austinol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of austinol formation" EXACT [GOC:TermGenie]
synonym: "down regulation of austinol synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of austinol anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of austinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of austinol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of austinol formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of austinol synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of austinol anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of austinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of austinol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of austinol formation" EXACT [GOC:TermGenie]
synonym: "downregulation of austinol synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of austinol anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of austinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of austinol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of austinol formation" EXACT [GOC:TermGenie]
synonym: "inhibition of austinol synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of austinol anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of austinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of austinol formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of austinol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:1900640 ! regulation of austinol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900560 ! austinol biosynthetic process
relationship: negatively_regulates GO:1900560 ! austinol biosynthetic process
created_by: di
creation_date: 2012-05-22T03:57:59Z

[Term]
id: GO:1900642
name: positive regulation of austinol biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of austinol biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of austinol anabolism" EXACT [GOC:TermGenie]
synonym: "activation of austinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of austinol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of austinol formation" EXACT [GOC:TermGenie]
synonym: "activation of austinol synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of austinol anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of austinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of austinol formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of austinol synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of austinol anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of austinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of austinol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of austinol formation" EXACT [GOC:TermGenie]
synonym: "up regulation of austinol synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of austinol anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of austinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of austinol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of austinol formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of austinol synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of austinol anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of austinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of austinol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of austinol formation" EXACT [GOC:TermGenie]
synonym: "upregulation of austinol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:1900640 ! regulation of austinol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900560 ! austinol biosynthetic process
relationship: positively_regulates GO:1900560 ! austinol biosynthetic process
created_by: di
creation_date: 2012-05-22T03:58:07Z

[Term]
id: GO:1900643
name: regulation of chanoclavine-I biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chanoclavine-I biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of chanoclavine-I anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of chanoclavine-I biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of chanoclavine-I formation" EXACT [GOC:TermGenie]
synonym: "regulation of chanoclavine-I synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900822 ! regulation of ergot alkaloid biosynthetic process
is_a: GO:1902930 ! regulation of alcohol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900566 ! chanoclavine-I biosynthetic process
relationship: regulates GO:1900566 ! chanoclavine-I biosynthetic process
created_by: di
creation_date: 2012-05-22T04:03:08Z

[Term]
id: GO:1900644
name: negative regulation of chanoclavine-I biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chanoclavine-I biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of chanoclavine-I anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of chanoclavine-I biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of chanoclavine-I biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of chanoclavine-I formation" EXACT [GOC:TermGenie]
synonym: "down regulation of chanoclavine-I synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of chanoclavine-I anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of chanoclavine-I biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of chanoclavine-I biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of chanoclavine-I formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of chanoclavine-I synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of chanoclavine-I anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of chanoclavine-I biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of chanoclavine-I biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of chanoclavine-I formation" EXACT [GOC:TermGenie]
synonym: "downregulation of chanoclavine-I synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of chanoclavine-I anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of chanoclavine-I biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of chanoclavine-I biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of chanoclavine-I formation" EXACT [GOC:TermGenie]
synonym: "inhibition of chanoclavine-I synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of chanoclavine-I anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of chanoclavine-I biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of chanoclavine-I formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of chanoclavine-I synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900643 ! regulation of chanoclavine-I biosynthetic process
is_a: GO:1900823 ! negative regulation of ergot alkaloid biosynthetic process
is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900566 ! chanoclavine-I biosynthetic process
relationship: negatively_regulates GO:1900566 ! chanoclavine-I biosynthetic process
created_by: di
creation_date: 2012-05-22T04:03:30Z

[Term]
id: GO:1900645
name: positive regulation of chanoclavine-I biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chanoclavine-I biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of chanoclavine-I anabolism" EXACT [GOC:TermGenie]
synonym: "activation of chanoclavine-I biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of chanoclavine-I biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of chanoclavine-I formation" EXACT [GOC:TermGenie]
synonym: "activation of chanoclavine-I synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of chanoclavine-I anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of chanoclavine-I biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of chanoclavine-I formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of chanoclavine-I synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of chanoclavine-I anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of chanoclavine-I biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of chanoclavine-I biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of chanoclavine-I formation" EXACT [GOC:TermGenie]
synonym: "up regulation of chanoclavine-I synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of chanoclavine-I anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of chanoclavine-I biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of chanoclavine-I biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of chanoclavine-I formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of chanoclavine-I synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of chanoclavine-I anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of chanoclavine-I biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of chanoclavine-I biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of chanoclavine-I formation" EXACT [GOC:TermGenie]
synonym: "upregulation of chanoclavine-I synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900643 ! regulation of chanoclavine-I biosynthetic process
is_a: GO:1900824 ! positive regulation of ergot alkaloid biosynthetic process
is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900566 ! chanoclavine-I biosynthetic process
relationship: positively_regulates GO:1900566 ! chanoclavine-I biosynthetic process
created_by: di
creation_date: 2012-05-22T04:03:38Z

[Term]
id: GO:1900646
name: regulation of chanoclavine-I aldehyde biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chanoclavine-I aldehyde biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of chanoclavine-I aldehyde anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of chanoclavine-I aldehyde biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of chanoclavine-I aldehyde formation" EXACT [GOC:TermGenie]
synonym: "regulation of chanoclavine-I aldehyde synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900822 ! regulation of ergot alkaloid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900569 ! chanoclavine-I aldehyde biosynthetic process
relationship: regulates GO:1900569 ! chanoclavine-I aldehyde biosynthetic process
created_by: di
creation_date: 2012-05-22T04:04:38Z

[Term]
id: GO:1900647
name: negative regulation of chanoclavine-I aldehyde biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chanoclavine-I aldehyde biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of chanoclavine-I aldehyde anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of chanoclavine-I aldehyde biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of chanoclavine-I aldehyde biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of chanoclavine-I aldehyde formation" EXACT [GOC:TermGenie]
synonym: "down regulation of chanoclavine-I aldehyde synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of chanoclavine-I aldehyde anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of chanoclavine-I aldehyde biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of chanoclavine-I aldehyde biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of chanoclavine-I aldehyde formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of chanoclavine-I aldehyde synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of chanoclavine-I aldehyde anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of chanoclavine-I aldehyde biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of chanoclavine-I aldehyde biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of chanoclavine-I aldehyde formation" EXACT [GOC:TermGenie]
synonym: "downregulation of chanoclavine-I aldehyde synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of chanoclavine-I aldehyde anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of chanoclavine-I aldehyde biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of chanoclavine-I aldehyde biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of chanoclavine-I aldehyde formation" EXACT [GOC:TermGenie]
synonym: "inhibition of chanoclavine-I aldehyde synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of chanoclavine-I aldehyde anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of chanoclavine-I aldehyde biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of chanoclavine-I aldehyde formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of chanoclavine-I aldehyde synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900646 ! regulation of chanoclavine-I aldehyde biosynthetic process
is_a: GO:1900823 ! negative regulation of ergot alkaloid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900569 ! chanoclavine-I aldehyde biosynthetic process
relationship: negatively_regulates GO:1900569 ! chanoclavine-I aldehyde biosynthetic process
created_by: di
creation_date: 2012-05-22T04:04:59Z

[Term]
id: GO:1900648
name: positive regulation of chanoclavine-I aldehyde biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chanoclavine-I aldehyde biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of chanoclavine-I aldehyde anabolism" EXACT [GOC:TermGenie]
synonym: "activation of chanoclavine-I aldehyde biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of chanoclavine-I aldehyde biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of chanoclavine-I aldehyde formation" EXACT [GOC:TermGenie]
synonym: "activation of chanoclavine-I aldehyde synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of chanoclavine-I aldehyde anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of chanoclavine-I aldehyde biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of chanoclavine-I aldehyde formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of chanoclavine-I aldehyde synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of chanoclavine-I aldehyde anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of chanoclavine-I aldehyde biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of chanoclavine-I aldehyde biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of chanoclavine-I aldehyde formation" EXACT [GOC:TermGenie]
synonym: "up regulation of chanoclavine-I aldehyde synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of chanoclavine-I aldehyde anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of chanoclavine-I aldehyde biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of chanoclavine-I aldehyde biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of chanoclavine-I aldehyde formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of chanoclavine-I aldehyde synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of chanoclavine-I aldehyde anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of chanoclavine-I aldehyde biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of chanoclavine-I aldehyde biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of chanoclavine-I aldehyde formation" EXACT [GOC:TermGenie]
synonym: "upregulation of chanoclavine-I aldehyde synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900646 ! regulation of chanoclavine-I aldehyde biosynthetic process
is_a: GO:1900824 ! positive regulation of ergot alkaloid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900569 ! chanoclavine-I aldehyde biosynthetic process
relationship: positively_regulates GO:1900569 ! chanoclavine-I aldehyde biosynthetic process
created_by: di
creation_date: 2012-05-22T04:05:06Z

[Term]
id: GO:1900649
name: regulation of dehydroaustinol biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dehydroaustinol biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of dehydroaustinol anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of dehydroaustinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of dehydroaustinol formation" EXACT [GOC:TermGenie]
synonym: "regulation of dehydroaustinol synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900563 ! dehydroaustinol biosynthetic process
relationship: regulates GO:1900563 ! dehydroaustinol biosynthetic process
created_by: di
creation_date: 2012-05-22T04:06:03Z

[Term]
id: GO:1900650
name: negative regulation of dehydroaustinol biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of dehydroaustinol biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of dehydroaustinol anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of dehydroaustinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of dehydroaustinol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of dehydroaustinol formation" EXACT [GOC:TermGenie]
synonym: "down regulation of dehydroaustinol synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of dehydroaustinol anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of dehydroaustinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of dehydroaustinol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of dehydroaustinol formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of dehydroaustinol synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of dehydroaustinol anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of dehydroaustinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of dehydroaustinol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of dehydroaustinol formation" EXACT [GOC:TermGenie]
synonym: "downregulation of dehydroaustinol synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of dehydroaustinol anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of dehydroaustinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of dehydroaustinol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of dehydroaustinol formation" EXACT [GOC:TermGenie]
synonym: "inhibition of dehydroaustinol synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of dehydroaustinol anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of dehydroaustinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of dehydroaustinol formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of dehydroaustinol synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900649 ! regulation of dehydroaustinol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900563 ! dehydroaustinol biosynthetic process
relationship: negatively_regulates GO:1900563 ! dehydroaustinol biosynthetic process
created_by: di
creation_date: 2012-05-22T04:06:22Z

[Term]
id: GO:1900651
name: positive regulation of dehydroaustinol biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of dehydroaustinol biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of dehydroaustinol anabolism" EXACT [GOC:TermGenie]
synonym: "activation of dehydroaustinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of dehydroaustinol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of dehydroaustinol formation" EXACT [GOC:TermGenie]
synonym: "activation of dehydroaustinol synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of dehydroaustinol anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of dehydroaustinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of dehydroaustinol formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of dehydroaustinol synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of dehydroaustinol anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of dehydroaustinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of dehydroaustinol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of dehydroaustinol formation" EXACT [GOC:TermGenie]
synonym: "up regulation of dehydroaustinol synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of dehydroaustinol anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of dehydroaustinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of dehydroaustinol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of dehydroaustinol formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of dehydroaustinol synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of dehydroaustinol anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of dehydroaustinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of dehydroaustinol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of dehydroaustinol formation" EXACT [GOC:TermGenie]
synonym: "upregulation of dehydroaustinol synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900649 ! regulation of dehydroaustinol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900563 ! dehydroaustinol biosynthetic process
relationship: positively_regulates GO:1900563 ! dehydroaustinol biosynthetic process
created_by: di
creation_date: 2012-05-22T04:06:30Z

[Term]
id: GO:1900652
name: regulation of demethylkotanin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of demethylkotanin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of demethylkotanin anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of demethylkotanin biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of demethylkotanin formation" EXACT [GOC:TermGenie]
synonym: "regulation of demethylkotanin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900599 ! demethylkotanin biosynthetic process
relationship: regulates GO:1900599 ! demethylkotanin biosynthetic process
created_by: di
creation_date: 2012-05-22T04:07:18Z

[Term]
id: GO:1900653
name: negative regulation of demethylkotanin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of demethylkotanin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of demethylkotanin anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of demethylkotanin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of demethylkotanin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of demethylkotanin formation" EXACT [GOC:TermGenie]
synonym: "down regulation of demethylkotanin synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of demethylkotanin anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of demethylkotanin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of demethylkotanin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of demethylkotanin formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of demethylkotanin synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of demethylkotanin anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of demethylkotanin biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of demethylkotanin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of demethylkotanin formation" EXACT [GOC:TermGenie]
synonym: "downregulation of demethylkotanin synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of demethylkotanin anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of demethylkotanin biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of demethylkotanin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of demethylkotanin formation" EXACT [GOC:TermGenie]
synonym: "inhibition of demethylkotanin synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of demethylkotanin anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of demethylkotanin biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of demethylkotanin formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of demethylkotanin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900652 ! regulation of demethylkotanin biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900599 ! demethylkotanin biosynthetic process
relationship: negatively_regulates GO:1900599 ! demethylkotanin biosynthetic process
created_by: di
creation_date: 2012-05-22T04:07:41Z

[Term]
id: GO:1900654
name: positive regulation of demethylkotanin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of demethylkotanin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of demethylkotanin anabolism" EXACT [GOC:TermGenie]
synonym: "activation of demethylkotanin biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of demethylkotanin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of demethylkotanin formation" EXACT [GOC:TermGenie]
synonym: "activation of demethylkotanin synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of demethylkotanin anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of demethylkotanin biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of demethylkotanin formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of demethylkotanin synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of demethylkotanin anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of demethylkotanin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of demethylkotanin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of demethylkotanin formation" EXACT [GOC:TermGenie]
synonym: "up regulation of demethylkotanin synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of demethylkotanin anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of demethylkotanin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of demethylkotanin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of demethylkotanin formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of demethylkotanin synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of demethylkotanin anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of demethylkotanin biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of demethylkotanin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of demethylkotanin formation" EXACT [GOC:TermGenie]
synonym: "upregulation of demethylkotanin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900652 ! regulation of demethylkotanin biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900599 ! demethylkotanin biosynthetic process
relationship: positively_regulates GO:1900599 ! demethylkotanin biosynthetic process
created_by: di
creation_date: 2012-05-22T04:07:49Z

[Term]
id: GO:1900655
name: regulation of diorcinol biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of diorcinol biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of diorcinol anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of diorcinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of diorcinol formation" EXACT [GOC:TermGenie]
synonym: "regulation of diorcinol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900572 ! diorcinol biosynthetic process
relationship: regulates GO:1900572 ! diorcinol biosynthetic process
created_by: di
creation_date: 2012-05-22T04:08:40Z

[Term]
id: GO:1900656
name: negative regulation of diorcinol biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of diorcinol biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of diorcinol anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of diorcinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of diorcinol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of diorcinol formation" EXACT [GOC:TermGenie]
synonym: "down regulation of diorcinol synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of diorcinol anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of diorcinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of diorcinol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of diorcinol formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of diorcinol synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of diorcinol anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of diorcinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of diorcinol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of diorcinol formation" EXACT [GOC:TermGenie]
synonym: "downregulation of diorcinol synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of diorcinol anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of diorcinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of diorcinol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of diorcinol formation" EXACT [GOC:TermGenie]
synonym: "inhibition of diorcinol synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of diorcinol anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of diorcinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of diorcinol formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of diorcinol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900655 ! regulation of diorcinol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900572 ! diorcinol biosynthetic process
relationship: negatively_regulates GO:1900572 ! diorcinol biosynthetic process
created_by: di
creation_date: 2012-05-22T04:09:01Z

[Term]
id: GO:1900657
name: positive regulation of diorcinol biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of diorcinol biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of diorcinol anabolism" EXACT [GOC:TermGenie]
synonym: "activation of diorcinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of diorcinol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of diorcinol formation" EXACT [GOC:TermGenie]
synonym: "activation of diorcinol synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of diorcinol anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of diorcinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of diorcinol formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of diorcinol synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of diorcinol anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of diorcinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of diorcinol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of diorcinol formation" EXACT [GOC:TermGenie]
synonym: "up regulation of diorcinol synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of diorcinol anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of diorcinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of diorcinol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of diorcinol formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of diorcinol synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of diorcinol anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of diorcinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of diorcinol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of diorcinol formation" EXACT [GOC:TermGenie]
synonym: "upregulation of diorcinol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900655 ! regulation of diorcinol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900572 ! diorcinol biosynthetic process
relationship: positively_regulates GO:1900572 ! diorcinol biosynthetic process
created_by: di
creation_date: 2012-05-22T04:09:08Z

[Term]
id: GO:1900658
name: regulation of emericellamide biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of emericellamide biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of emericellamide anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of emericellamide biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of emericellamide formation" EXACT [GOC:TermGenie]
synonym: "regulation of emericellamide synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0034248 ! regulation of cellular amide metabolic process
is_a: GO:0046890 ! regulation of lipid biosynthetic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900557 ! emericellamide biosynthetic process
relationship: regulates GO:1900557 ! emericellamide biosynthetic process
created_by: di
creation_date: 2012-05-22T04:10:19Z

[Term]
id: GO:1900659
name: negative regulation of emericellamide biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of emericellamide biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of emericellamide anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of emericellamide biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of emericellamide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of emericellamide formation" EXACT [GOC:TermGenie]
synonym: "down regulation of emericellamide synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of emericellamide anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of emericellamide biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of emericellamide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of emericellamide formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of emericellamide synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of emericellamide anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of emericellamide biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of emericellamide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of emericellamide formation" EXACT [GOC:TermGenie]
synonym: "downregulation of emericellamide synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of emericellamide anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of emericellamide biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of emericellamide biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of emericellamide formation" EXACT [GOC:TermGenie]
synonym: "inhibition of emericellamide synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of emericellamide anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of emericellamide biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of emericellamide formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of emericellamide synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0034249 ! negative regulation of cellular amide metabolic process
is_a: GO:0051055 ! negative regulation of lipid biosynthetic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900658 ! regulation of emericellamide biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900557 ! emericellamide biosynthetic process
relationship: negatively_regulates GO:1900557 ! emericellamide biosynthetic process
created_by: di
creation_date: 2012-05-22T04:10:44Z

[Term]
id: GO:1900660
name: positive regulation of emericellamide biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of emericellamide biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of emericellamide anabolism" EXACT [GOC:TermGenie]
synonym: "activation of emericellamide biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of emericellamide biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of emericellamide formation" EXACT [GOC:TermGenie]
synonym: "activation of emericellamide synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of emericellamide anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of emericellamide biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of emericellamide formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of emericellamide synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of emericellamide anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of emericellamide biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of emericellamide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of emericellamide formation" EXACT [GOC:TermGenie]
synonym: "up regulation of emericellamide synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of emericellamide anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of emericellamide biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of emericellamide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of emericellamide formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of emericellamide synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of emericellamide anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of emericellamide biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of emericellamide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of emericellamide formation" EXACT [GOC:TermGenie]
synonym: "upregulation of emericellamide synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0034250 ! positive regulation of cellular amide metabolic process
is_a: GO:0046889 ! positive regulation of lipid biosynthetic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900658 ! regulation of emericellamide biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900557 ! emericellamide biosynthetic process
relationship: positively_regulates GO:1900557 ! emericellamide biosynthetic process
created_by: di
creation_date: 2012-05-22T04:10:51Z

[Term]
id: GO:1900661
name: regulation of emericellamide A biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of emericellamide A biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of emericellamide A anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of emericellamide A biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of emericellamide A formation" EXACT [GOC:TermGenie]
synonym: "regulation of emericellamide A synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900658 ! regulation of emericellamide biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900617 ! emericellamide A biosynthetic process
relationship: regulates GO:1900617 ! emericellamide A biosynthetic process
created_by: di
creation_date: 2012-05-22T04:13:07Z

[Term]
id: GO:1900662
name: negative regulation of emericellamide A biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of emericellamide A biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of emericellamide A anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of emericellamide A biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of emericellamide A biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of emericellamide A formation" EXACT [GOC:TermGenie]
synonym: "down regulation of emericellamide A synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of emericellamide A anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of emericellamide A biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of emericellamide A biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of emericellamide A formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of emericellamide A synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of emericellamide A anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of emericellamide A biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of emericellamide A biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of emericellamide A formation" EXACT [GOC:TermGenie]
synonym: "downregulation of emericellamide A synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of emericellamide A anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of emericellamide A biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of emericellamide A biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of emericellamide A formation" EXACT [GOC:TermGenie]
synonym: "inhibition of emericellamide A synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of emericellamide A anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of emericellamide A biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of emericellamide A formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of emericellamide A synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900659 ! negative regulation of emericellamide biosynthetic process
is_a: GO:1900661 ! regulation of emericellamide A biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900617 ! emericellamide A biosynthetic process
relationship: negatively_regulates GO:1900617 ! emericellamide A biosynthetic process
created_by: di
creation_date: 2012-05-22T04:13:28Z

[Term]
id: GO:1900663
name: positive regulation of emericellamide A biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of emericellamide A biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of emericellamide A anabolism" EXACT [GOC:TermGenie]
synonym: "activation of emericellamide A biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of emericellamide A biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of emericellamide A formation" EXACT [GOC:TermGenie]
synonym: "activation of emericellamide A synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of emericellamide A anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of emericellamide A biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of emericellamide A formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of emericellamide A synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of emericellamide A anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of emericellamide A biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of emericellamide A biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of emericellamide A formation" EXACT [GOC:TermGenie]
synonym: "up regulation of emericellamide A synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of emericellamide A anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of emericellamide A biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of emericellamide A biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of emericellamide A formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of emericellamide A synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of emericellamide A anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of emericellamide A biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of emericellamide A biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of emericellamide A formation" EXACT [GOC:TermGenie]
synonym: "upregulation of emericellamide A synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900660 ! positive regulation of emericellamide biosynthetic process
is_a: GO:1900661 ! regulation of emericellamide A biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900617 ! emericellamide A biosynthetic process
relationship: positively_regulates GO:1900617 ! emericellamide A biosynthetic process
created_by: di
creation_date: 2012-05-22T04:13:36Z

[Term]
id: GO:1900664
name: regulation of emodin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of emodin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of emodin anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of emodin biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of emodin formation" EXACT [GOC:TermGenie]
synonym: "regulation of emodin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010566 ! regulation of ketone biosynthetic process
is_a: GO:0051196 ! regulation of coenzyme metabolic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900575 ! emodin biosynthetic process
relationship: regulates GO:1900575 ! emodin biosynthetic process
created_by: di
creation_date: 2012-05-22T04:14:36Z

[Term]
id: GO:1900665
name: negative regulation of emodin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of emodin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of emodin anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of emodin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of emodin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of emodin formation" EXACT [GOC:TermGenie]
synonym: "down regulation of emodin synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of emodin anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of emodin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of emodin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of emodin formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of emodin synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of emodin anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of emodin biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of emodin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of emodin formation" EXACT [GOC:TermGenie]
synonym: "downregulation of emodin synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of emodin anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of emodin biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of emodin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of emodin formation" EXACT [GOC:TermGenie]
synonym: "inhibition of emodin synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of emodin anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of emodin biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of emodin formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of emodin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0051198 ! negative regulation of coenzyme metabolic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900664 ! regulation of emodin biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900575 ! emodin biosynthetic process
relationship: negatively_regulates GO:1900575 ! emodin biosynthetic process
created_by: di
creation_date: 2012-05-22T04:14:58Z

[Term]
id: GO:1900666
name: positive regulation of emodin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of emodin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of emodin anabolism" EXACT [GOC:TermGenie]
synonym: "activation of emodin biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of emodin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of emodin formation" EXACT [GOC:TermGenie]
synonym: "activation of emodin synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of emodin anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of emodin biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of emodin formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of emodin synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of emodin anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of emodin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of emodin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of emodin formation" EXACT [GOC:TermGenie]
synonym: "up regulation of emodin synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of emodin anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of emodin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of emodin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of emodin formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of emodin synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of emodin anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of emodin biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of emodin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of emodin formation" EXACT [GOC:TermGenie]
synonym: "upregulation of emodin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0051197 ! positive regulation of coenzyme metabolic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900664 ! regulation of emodin biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900575 ! emodin biosynthetic process
relationship: positively_regulates GO:1900575 ! emodin biosynthetic process
created_by: di
creation_date: 2012-05-22T04:15:06Z

[Term]
id: GO:1900667
name: regulation of endocrocin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endocrocin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of endocrocin anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of endocrocin biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of endocrocin formation" EXACT [GOC:TermGenie]
synonym: "regulation of endocrocin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010566 ! regulation of ketone biosynthetic process
is_a: GO:0051196 ! regulation of coenzyme metabolic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900602 ! endocrocin biosynthetic process
relationship: regulates GO:1900602 ! endocrocin biosynthetic process
created_by: di
creation_date: 2012-05-22T04:16:04Z

[Term]
id: GO:1900668
name: negative regulation of endocrocin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of endocrocin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of endocrocin anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of endocrocin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of endocrocin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of endocrocin formation" EXACT [GOC:TermGenie]
synonym: "down regulation of endocrocin synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of endocrocin anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of endocrocin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of endocrocin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of endocrocin formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of endocrocin synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of endocrocin anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of endocrocin biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of endocrocin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of endocrocin formation" EXACT [GOC:TermGenie]
synonym: "downregulation of endocrocin synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of endocrocin anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of endocrocin biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of endocrocin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of endocrocin formation" EXACT [GOC:TermGenie]
synonym: "inhibition of endocrocin synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of endocrocin anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of endocrocin biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of endocrocin formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of endocrocin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0051198 ! negative regulation of coenzyme metabolic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900667 ! regulation of endocrocin biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900602 ! endocrocin biosynthetic process
relationship: negatively_regulates GO:1900602 ! endocrocin biosynthetic process
created_by: di
creation_date: 2012-05-22T04:16:25Z

[Term]
id: GO:1900669
name: positive regulation of endocrocin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endocrocin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of endocrocin anabolism" EXACT [GOC:TermGenie]
synonym: "activation of endocrocin biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of endocrocin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of endocrocin formation" EXACT [GOC:TermGenie]
synonym: "activation of endocrocin synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of endocrocin anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of endocrocin biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of endocrocin formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of endocrocin synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of endocrocin anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of endocrocin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of endocrocin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of endocrocin formation" EXACT [GOC:TermGenie]
synonym: "up regulation of endocrocin synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of endocrocin anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of endocrocin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of endocrocin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of endocrocin formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of endocrocin synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of endocrocin anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of endocrocin biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of endocrocin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of endocrocin formation" EXACT [GOC:TermGenie]
synonym: "upregulation of endocrocin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0051197 ! positive regulation of coenzyme metabolic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900667 ! regulation of endocrocin biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900602 ! endocrocin biosynthetic process
relationship: positively_regulates GO:1900602 ! endocrocin biosynthetic process
created_by: di
creation_date: 2012-05-22T04:16:35Z

[Term]
id: GO:1900670
name: regulation of F-9775A biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of F-9775A biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of F-9775A anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of F-9775A biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of F-9775A formation" EXACT [GOC:TermGenie]
synonym: "regulation of F-9775A synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900732 ! regulation of polyketide biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900611 ! F-9775A biosynthetic process
relationship: regulates GO:1900611 ! F-9775A biosynthetic process
created_by: di
creation_date: 2012-05-22T04:24:09Z

[Term]
id: GO:1900671
name: negative regulation of F-9775A biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of F-9775A biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of F-9775A anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of F-9775A biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of F-9775A biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of F-9775A formation" EXACT [GOC:TermGenie]
synonym: "down regulation of F-9775A synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of F-9775A anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of F-9775A biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of F-9775A biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of F-9775A formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of F-9775A synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of F-9775A anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of F-9775A biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of F-9775A biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of F-9775A formation" EXACT [GOC:TermGenie]
synonym: "downregulation of F-9775A synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of F-9775A anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of F-9775A biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of F-9775A biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of F-9775A formation" EXACT [GOC:TermGenie]
synonym: "inhibition of F-9775A synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of F-9775A anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of F-9775A biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of F-9775A formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of F-9775A synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900670 ! regulation of F-9775A biosynthetic process
is_a: GO:1900733 ! negative regulation of polyketide biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900611 ! F-9775A biosynthetic process
relationship: negatively_regulates GO:1900611 ! F-9775A biosynthetic process
created_by: di
creation_date: 2012-05-22T04:24:30Z

[Term]
id: GO:1900672
name: positive regulation of F-9775A biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of F-9775A biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of F-9775A anabolism" EXACT [GOC:TermGenie]
synonym: "activation of F-9775A biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of F-9775A biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of F-9775A formation" EXACT [GOC:TermGenie]
synonym: "activation of F-9775A synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of F-9775A anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of F-9775A biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of F-9775A formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of F-9775A synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of F-9775A anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of F-9775A biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of F-9775A biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of F-9775A formation" EXACT [GOC:TermGenie]
synonym: "up regulation of F-9775A synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of F-9775A anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of F-9775A biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of F-9775A biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of F-9775A formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of F-9775A synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of F-9775A anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of F-9775A biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of F-9775A biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of F-9775A formation" EXACT [GOC:TermGenie]
synonym: "upregulation of F-9775A synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900670 ! regulation of F-9775A biosynthetic process
is_a: GO:1900734 ! positive regulation of polyketide biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900611 ! F-9775A biosynthetic process
relationship: positively_regulates GO:1900611 ! F-9775A biosynthetic process
created_by: di
creation_date: 2012-05-22T04:24:37Z

[Term]
id: GO:1900673
name: olefin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving olefin." [GOC:mengo_curators, GOC:TermGenie]
synonym: "olefin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0071704 ! organic substance metabolic process
created_by: tt
creation_date: 2012-05-22T04:24:42Z

[Term]
id: GO:1900674
name: olefin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of olefin." [GOC:mengo_curators, GOC:TermGenie]
synonym: "olefin anabolism" EXACT [GOC:TermGenie]
synonym: "olefin biosynthesis" EXACT [GOC:TermGenie]
synonym: "olefin formation" EXACT [GOC:TermGenie]
synonym: "olefin synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900673 ! olefin metabolic process
is_a: GO:1901576 ! organic substance biosynthetic process
created_by: tt
creation_date: 2012-05-22T04:25:03Z

[Term]
id: GO:1900675
name: regulation of F-9775B biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of F-9775B biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of F-9775B anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of F-9775B biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of F-9775B formation" EXACT [GOC:TermGenie]
synonym: "regulation of F-9775B synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900732 ! regulation of polyketide biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900614 ! F-9775B biosynthetic process
relationship: regulates GO:1900614 ! F-9775B biosynthetic process
created_by: di
creation_date: 2012-05-22T04:26:31Z

[Term]
id: GO:1900676
name: negative regulation of F-9775B biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of F-9775B biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of F-9775B anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of F-9775B biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of F-9775B biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of F-9775B formation" EXACT [GOC:TermGenie]
synonym: "down regulation of F-9775B synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of F-9775B anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of F-9775B biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of F-9775B biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of F-9775B formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of F-9775B synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of F-9775B anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of F-9775B biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of F-9775B biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of F-9775B formation" EXACT [GOC:TermGenie]
synonym: "downregulation of F-9775B synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of F-9775B anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of F-9775B biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of F-9775B biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of F-9775B formation" EXACT [GOC:TermGenie]
synonym: "inhibition of F-9775B synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of F-9775B anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of F-9775B biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of F-9775B formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of F-9775B synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900675 ! regulation of F-9775B biosynthetic process
is_a: GO:1900733 ! negative regulation of polyketide biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900614 ! F-9775B biosynthetic process
relationship: negatively_regulates GO:1900614 ! F-9775B biosynthetic process
created_by: di
creation_date: 2012-05-22T04:26:53Z

[Term]
id: GO:1900677
name: positive regulation of F-9775B biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of F-9775B biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of F-9775B anabolism" EXACT [GOC:TermGenie]
synonym: "activation of F-9775B biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of F-9775B biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of F-9775B formation" EXACT [GOC:TermGenie]
synonym: "activation of F-9775B synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of F-9775B anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of F-9775B biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of F-9775B formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of F-9775B synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of F-9775B anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of F-9775B biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of F-9775B biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of F-9775B formation" EXACT [GOC:TermGenie]
synonym: "up regulation of F-9775B synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of F-9775B anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of F-9775B biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of F-9775B biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of F-9775B formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of F-9775B synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of F-9775B anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of F-9775B biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of F-9775B biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of F-9775B formation" EXACT [GOC:TermGenie]
synonym: "upregulation of F-9775B synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900675 ! regulation of F-9775B biosynthetic process
is_a: GO:1900734 ! positive regulation of polyketide biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900614 ! F-9775B biosynthetic process
relationship: positively_regulates GO:1900614 ! F-9775B biosynthetic process
created_by: di
creation_date: 2012-05-22T04:27:01Z

[Term]
id: GO:1900678
name: regulation of ferricrocin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ferricrocin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of ferricrocin anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of ferricrocin biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of ferricrocin biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "regulation of ferricrocin biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "regulation of ferricrocin formation" EXACT [GOC:TermGenie]
synonym: "regulation of ferricrocin synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900704 ! regulation of siderophore biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031171 ! ferricrocin biosynthetic process
relationship: regulates GO:0031171 ! ferricrocin biosynthetic process
created_by: di
creation_date: 2012-05-22T04:27:53Z

[Term]
id: GO:1900679
name: negative regulation of ferricrocin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ferricrocin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of ferricrocin anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of ferricrocin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of ferricrocin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of ferricrocin biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "down regulation of ferricrocin biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "down regulation of ferricrocin formation" EXACT [GOC:TermGenie]
synonym: "down regulation of ferricrocin synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of ferricrocin anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of ferricrocin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of ferricrocin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of ferricrocin biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "down-regulation of ferricrocin biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "down-regulation of ferricrocin formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of ferricrocin synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of ferricrocin anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of ferricrocin biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of ferricrocin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of ferricrocin biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "downregulation of ferricrocin biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "downregulation of ferricrocin formation" EXACT [GOC:TermGenie]
synonym: "downregulation of ferricrocin synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of ferricrocin anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of ferricrocin biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of ferricrocin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of ferricrocin biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "inhibition of ferricrocin biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "inhibition of ferricrocin formation" EXACT [GOC:TermGenie]
synonym: "inhibition of ferricrocin synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of ferricrocin anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of ferricrocin biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of ferricrocin biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of ferricrocin biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "negative regulation of ferricrocin formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of ferricrocin synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900678 ! regulation of ferricrocin biosynthetic process
is_a: GO:1900705 ! negative regulation of siderophore biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0031171 ! ferricrocin biosynthetic process
relationship: negatively_regulates GO:0031171 ! ferricrocin biosynthetic process
created_by: di
creation_date: 2012-05-22T04:28:15Z

[Term]
id: GO:1900680
name: positive regulation of ferricrocin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ferricrocin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of ferricrocin anabolism" EXACT [GOC:TermGenie]
synonym: "activation of ferricrocin biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of ferricrocin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of ferricrocin biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "activation of ferricrocin biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "activation of ferricrocin formation" EXACT [GOC:TermGenie]
synonym: "activation of ferricrocin synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of ferricrocin anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of ferricrocin biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of ferricrocin biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of ferricrocin biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "positive regulation of ferricrocin formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of ferricrocin synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of ferricrocin anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of ferricrocin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of ferricrocin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of ferricrocin biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "up regulation of ferricrocin biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "up regulation of ferricrocin formation" EXACT [GOC:TermGenie]
synonym: "up regulation of ferricrocin synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of ferricrocin anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of ferricrocin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of ferricrocin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of ferricrocin biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "up-regulation of ferricrocin biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "up-regulation of ferricrocin formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of ferricrocin synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of ferricrocin anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of ferricrocin biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of ferricrocin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of ferricrocin biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "upregulation of ferricrocin biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "upregulation of ferricrocin formation" EXACT [GOC:TermGenie]
synonym: "upregulation of ferricrocin synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900678 ! regulation of ferricrocin biosynthetic process
is_a: GO:1900706 ! positive regulation of siderophore biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0031171 ! ferricrocin biosynthetic process
relationship: positively_regulates GO:0031171 ! ferricrocin biosynthetic process
created_by: di
creation_date: 2012-05-22T04:28:23Z

[Term]
id: GO:1900681
name: octadecene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving octadecene." [GOC:mengo_curators, GOC:TermGenie]
synonym: "octadecene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0043449 ! cellular alkene metabolic process
created_by: tt
creation_date: 2012-05-22T04:28:28Z

[Term]
id: GO:1900682
name: octadecene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of octadecene." [GOC:mengo_curators, GOC:TermGenie]
synonym: "1-octadecene biosynthetic process" EXACT [GOC:mengo_curators]
synonym: "octadecene anabolism" EXACT [GOC:TermGenie]
synonym: "octadecene biosynthesis" EXACT [GOC:TermGenie]
synonym: "octadecene formation" EXACT [GOC:TermGenie]
synonym: "octadecene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0043450 ! alkene biosynthetic process
is_a: GO:1900681 ! octadecene metabolic process
created_by: tt
creation_date: 2012-05-22T04:28:49Z

[Term]
id: GO:1900683
name: regulation of fumonisin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fumonisin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of fumonisin anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of fumonisin biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of fumonisin formation" EXACT [GOC:TermGenie]
synonym: "regulation of fumonisin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010565 ! regulation of cellular ketone metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900541 ! fumonisin biosynthetic process
relationship: regulates GO:1900541 ! fumonisin biosynthetic process
created_by: di
creation_date: 2012-05-22T04:29:38Z

[Term]
id: GO:1900684
name: negative regulation of fumonisin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of fumonisin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of fumonisin anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of fumonisin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of fumonisin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of fumonisin formation" EXACT [GOC:TermGenie]
synonym: "down regulation of fumonisin synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of fumonisin anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of fumonisin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of fumonisin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of fumonisin formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of fumonisin synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of fumonisin anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of fumonisin biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of fumonisin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of fumonisin formation" EXACT [GOC:TermGenie]
synonym: "downregulation of fumonisin synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of fumonisin anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of fumonisin biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of fumonisin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of fumonisin formation" EXACT [GOC:TermGenie]
synonym: "inhibition of fumonisin synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of fumonisin anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of fumonisin biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of fumonisin formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of fumonisin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900683 ! regulation of fumonisin biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900541 ! fumonisin biosynthetic process
relationship: negatively_regulates GO:1900541 ! fumonisin biosynthetic process
created_by: di
creation_date: 2012-05-22T04:29:59Z

[Term]
id: GO:1900685
name: positive regulation of fumonisin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of fumonisin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of fumonisin anabolism" EXACT [GOC:TermGenie]
synonym: "activation of fumonisin biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of fumonisin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of fumonisin formation" EXACT [GOC:TermGenie]
synonym: "activation of fumonisin synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of fumonisin anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of fumonisin biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of fumonisin formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of fumonisin synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of fumonisin anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of fumonisin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of fumonisin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of fumonisin formation" EXACT [GOC:TermGenie]
synonym: "up regulation of fumonisin synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of fumonisin anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of fumonisin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of fumonisin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of fumonisin formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of fumonisin synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of fumonisin anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of fumonisin biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of fumonisin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of fumonisin formation" EXACT [GOC:TermGenie]
synonym: "upregulation of fumonisin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900683 ! regulation of fumonisin biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900541 ! fumonisin biosynthetic process
relationship: positively_regulates GO:1900541 ! fumonisin biosynthetic process
created_by: di
creation_date: 2012-05-22T04:30:06Z

[Term]
id: GO:1900686
name: regulation of gerfelin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gerfelin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of gerfelin anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of gerfelin biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of gerfelin formation" EXACT [GOC:TermGenie]
synonym: "regulation of gerfelin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010565 ! regulation of cellular ketone metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900578 ! gerfelin biosynthetic process
relationship: regulates GO:1900578 ! gerfelin biosynthetic process
created_by: di
creation_date: 2012-05-22T04:49:44Z

[Term]
id: GO:1900687
name: negative regulation of gerfelin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of gerfelin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of gerfelin anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of gerfelin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of gerfelin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of gerfelin formation" EXACT [GOC:TermGenie]
synonym: "down regulation of gerfelin synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of gerfelin anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of gerfelin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of gerfelin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of gerfelin formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of gerfelin synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of gerfelin anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of gerfelin biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of gerfelin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of gerfelin formation" EXACT [GOC:TermGenie]
synonym: "downregulation of gerfelin synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of gerfelin anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of gerfelin biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of gerfelin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of gerfelin formation" EXACT [GOC:TermGenie]
synonym: "inhibition of gerfelin synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of gerfelin anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of gerfelin biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of gerfelin formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of gerfelin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900686 ! regulation of gerfelin biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900578 ! gerfelin biosynthetic process
relationship: negatively_regulates GO:1900578 ! gerfelin biosynthetic process
created_by: di
creation_date: 2012-05-22T04:50:05Z

[Term]
id: GO:1900688
name: positive regulation of gerfelin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of gerfelin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of gerfelin anabolism" EXACT [GOC:TermGenie]
synonym: "activation of gerfelin biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of gerfelin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of gerfelin formation" EXACT [GOC:TermGenie]
synonym: "activation of gerfelin synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of gerfelin anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of gerfelin biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of gerfelin formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of gerfelin synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of gerfelin anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of gerfelin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of gerfelin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of gerfelin formation" EXACT [GOC:TermGenie]
synonym: "up regulation of gerfelin synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of gerfelin anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of gerfelin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of gerfelin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of gerfelin formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of gerfelin synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of gerfelin anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of gerfelin biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of gerfelin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of gerfelin formation" EXACT [GOC:TermGenie]
synonym: "upregulation of gerfelin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900686 ! regulation of gerfelin biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900578 ! gerfelin biosynthetic process
relationship: positively_regulates GO:1900578 ! gerfelin biosynthetic process
created_by: di
creation_date: 2012-05-22T04:50:12Z

[Term]
id: GO:1900689
name: regulation of gliotoxin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gliotoxin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of gliotoxin anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of gliotoxin biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of gliotoxin formation" EXACT [GOC:TermGenie]
synonym: "regulation of gliotoxin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0034248 ! regulation of cellular amide metabolic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:2001310 ! gliotoxin biosynthetic process
relationship: regulates GO:2001310 ! gliotoxin biosynthetic process
created_by: di
creation_date: 2012-05-22T04:51:38Z

[Term]
id: GO:1900690
name: negative regulation of gliotoxin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of gliotoxin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of gliotoxin anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of gliotoxin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of gliotoxin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of gliotoxin formation" EXACT [GOC:TermGenie]
synonym: "down regulation of gliotoxin synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of gliotoxin anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of gliotoxin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of gliotoxin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of gliotoxin formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of gliotoxin synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of gliotoxin anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of gliotoxin biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of gliotoxin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of gliotoxin formation" EXACT [GOC:TermGenie]
synonym: "downregulation of gliotoxin synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of gliotoxin anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of gliotoxin biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of gliotoxin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of gliotoxin formation" EXACT [GOC:TermGenie]
synonym: "inhibition of gliotoxin synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of gliotoxin anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of gliotoxin biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of gliotoxin formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of gliotoxin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0034249 ! negative regulation of cellular amide metabolic process
is_a: GO:0051175 ! negative regulation of sulfur metabolic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900689 ! regulation of gliotoxin biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:2001310 ! gliotoxin biosynthetic process
relationship: negatively_regulates GO:2001310 ! gliotoxin biosynthetic process
created_by: di
creation_date: 2012-05-22T04:52:00Z

[Term]
id: GO:1900691
name: positive regulation of gliotoxin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of gliotoxin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of gliotoxin anabolism" EXACT [GOC:TermGenie]
synonym: "activation of gliotoxin biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of gliotoxin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of gliotoxin formation" EXACT [GOC:TermGenie]
synonym: "activation of gliotoxin synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of gliotoxin anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of gliotoxin biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of gliotoxin formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of gliotoxin synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of gliotoxin anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of gliotoxin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of gliotoxin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of gliotoxin formation" EXACT [GOC:TermGenie]
synonym: "up regulation of gliotoxin synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of gliotoxin anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of gliotoxin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of gliotoxin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of gliotoxin formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of gliotoxin synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of gliotoxin anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of gliotoxin biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of gliotoxin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of gliotoxin formation" EXACT [GOC:TermGenie]
synonym: "upregulation of gliotoxin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0034250 ! positive regulation of cellular amide metabolic process
is_a: GO:0051176 ! positive regulation of sulfur metabolic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900689 ! regulation of gliotoxin biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:2001310 ! gliotoxin biosynthetic process
relationship: positively_regulates GO:2001310 ! gliotoxin biosynthetic process
created_by: di
creation_date: 2012-05-22T04:52:08Z

[Term]
id: GO:1900692
name: regulation of (+)-kotanin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of (+)-kotanin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of (+)-kotanin anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of (+)-kotanin biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of (+)-kotanin formation" EXACT [GOC:TermGenie]
synonym: "regulation of (+)-kotanin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900596 ! (+)-kotanin biosynthetic process
relationship: regulates GO:1900596 ! (+)-kotanin biosynthetic process
created_by: di
creation_date: 2012-05-22T04:53:04Z

[Term]
id: GO:1900693
name: negative regulation of (+)-kotanin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of (+)-kotanin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of (+)-kotanin anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of (+)-kotanin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of (+)-kotanin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of (+)-kotanin formation" EXACT [GOC:TermGenie]
synonym: "down regulation of (+)-kotanin synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of (+)-kotanin anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of (+)-kotanin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of (+)-kotanin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of (+)-kotanin formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of (+)-kotanin synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of (+)-kotanin anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of (+)-kotanin biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of (+)-kotanin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of (+)-kotanin formation" EXACT [GOC:TermGenie]
synonym: "downregulation of (+)-kotanin synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of (+)-kotanin anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of (+)-kotanin biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of (+)-kotanin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of (+)-kotanin formation" EXACT [GOC:TermGenie]
synonym: "inhibition of (+)-kotanin synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of (+)-kotanin anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of (+)-kotanin biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of (+)-kotanin formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of (+)-kotanin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900692 ! regulation of (+)-kotanin biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900596 ! (+)-kotanin biosynthetic process
relationship: negatively_regulates GO:1900596 ! (+)-kotanin biosynthetic process
created_by: di
creation_date: 2012-05-22T04:53:26Z

[Term]
id: GO:1900694
name: positive regulation of (+)-kotanin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of (+)-kotanin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of (+)-kotanin anabolism" EXACT [GOC:TermGenie]
synonym: "activation of (+)-kotanin biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of (+)-kotanin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of (+)-kotanin formation" EXACT [GOC:TermGenie]
synonym: "activation of (+)-kotanin synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of (+)-kotanin anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of (+)-kotanin biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of (+)-kotanin formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of (+)-kotanin synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of (+)-kotanin anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of (+)-kotanin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of (+)-kotanin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of (+)-kotanin formation" EXACT [GOC:TermGenie]
synonym: "up regulation of (+)-kotanin synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of (+)-kotanin anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of (+)-kotanin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of (+)-kotanin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of (+)-kotanin formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of (+)-kotanin synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of (+)-kotanin anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of (+)-kotanin biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of (+)-kotanin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of (+)-kotanin formation" EXACT [GOC:TermGenie]
synonym: "upregulation of (+)-kotanin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900692 ! regulation of (+)-kotanin biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900596 ! (+)-kotanin biosynthetic process
relationship: positively_regulates GO:1900596 ! (+)-kotanin biosynthetic process
created_by: di
creation_date: 2012-05-22T04:53:33Z

[Term]
id: GO:1900695
name: regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of N',N'',N'''-triacetylfusarinine C biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of N',N'',N'''-triacetylfusarinine C anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of N',N'',N'''-triacetylfusarinine C biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of N',N'',N'''-triacetylfusarinine C formation" EXACT [GOC:TermGenie]
synonym: "regulation of N',N'',N'''-triacetylfusarinine C synthesis" EXACT [GOC:TermGenie]
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900551 ! N',N'',N'''-triacetylfusarinine C biosynthetic process
relationship: regulates GO:1900551 ! N',N'',N'''-triacetylfusarinine C biosynthetic process
created_by: di
creation_date: 2012-05-22T04:54:24Z

[Term]
id: GO:1900696
name: negative regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of N',N'',N'''-triacetylfusarinine C biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of N',N'',N'''-triacetylfusarinine C anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of N',N'',N'''-triacetylfusarinine C biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of N',N'',N'''-triacetylfusarinine C formation" EXACT [GOC:TermGenie]
synonym: "down regulation of N',N'',N'''-triacetylfusarinine C synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of N',N'',N'''-triacetylfusarinine C anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of N',N'',N'''-triacetylfusarinine C biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of N',N'',N'''-triacetylfusarinine C formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of N',N'',N'''-triacetylfusarinine C synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of N',N'',N'''-triacetylfusarinine C anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of N',N'',N'''-triacetylfusarinine C biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of N',N'',N'''-triacetylfusarinine C biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of N',N'',N'''-triacetylfusarinine C formation" EXACT [GOC:TermGenie]
synonym: "downregulation of N',N'',N'''-triacetylfusarinine C synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of N',N'',N'''-triacetylfusarinine C anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of N',N'',N'''-triacetylfusarinine C biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of N',N'',N'''-triacetylfusarinine C biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of N',N'',N'''-triacetylfusarinine C formation" EXACT [GOC:TermGenie]
synonym: "inhibition of N',N'',N'''-triacetylfusarinine C synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of N',N'',N'''-triacetylfusarinine C anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of N',N'',N'''-triacetylfusarinine C biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of N',N'',N'''-triacetylfusarinine C formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of N',N'',N'''-triacetylfusarinine C synthesis" EXACT [GOC:TermGenie]
is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900695 ! regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900551 ! N',N'',N'''-triacetylfusarinine C biosynthetic process
relationship: negatively_regulates GO:1900551 ! N',N'',N'''-triacetylfusarinine C biosynthetic process
created_by: di
creation_date: 2012-05-22T04:54:45Z

[Term]
id: GO:1900697
name: positive regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of N',N'',N'''-triacetylfusarinine C biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of N',N'',N'''-triacetylfusarinine C anabolism" EXACT [GOC:TermGenie]
synonym: "activation of N',N'',N'''-triacetylfusarinine C biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of N',N'',N'''-triacetylfusarinine C biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of N',N'',N'''-triacetylfusarinine C formation" EXACT [GOC:TermGenie]
synonym: "activation of N',N'',N'''-triacetylfusarinine C synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of N',N'',N'''-triacetylfusarinine C anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of N',N'',N'''-triacetylfusarinine C biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of N',N'',N'''-triacetylfusarinine C formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of N',N'',N'''-triacetylfusarinine C synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of N',N'',N'''-triacetylfusarinine C anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of N',N'',N'''-triacetylfusarinine C biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of N',N'',N'''-triacetylfusarinine C formation" EXACT [GOC:TermGenie]
synonym: "up regulation of N',N'',N'''-triacetylfusarinine C synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of N',N'',N'''-triacetylfusarinine C anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of N',N'',N'''-triacetylfusarinine C biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of N',N'',N'''-triacetylfusarinine C formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of N',N'',N'''-triacetylfusarinine C synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of N',N'',N'''-triacetylfusarinine C anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of N',N'',N'''-triacetylfusarinine C biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of N',N'',N'''-triacetylfusarinine C biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of N',N'',N'''-triacetylfusarinine C formation" EXACT [GOC:TermGenie]
synonym: "upregulation of N',N'',N'''-triacetylfusarinine C synthesis" EXACT [GOC:TermGenie]
is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900695 ! regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900551 ! N',N'',N'''-triacetylfusarinine C biosynthetic process
relationship: positively_regulates GO:1900551 ! N',N'',N'''-triacetylfusarinine C biosynthetic process
created_by: di
creation_date: 2012-05-22T04:54:56Z

[Term]
id: GO:1900698
name: regulation of o-orsellinic acid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of o-orsellinic acid biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of o-orsellinic acid anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of o-orsellinic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of o-orsellinic acid formation" EXACT [GOC:TermGenie]
synonym: "regulation of o-orsellinic acid synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010565 ! regulation of cellular ketone metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900584 ! o-orsellinic acid biosynthetic process
relationship: regulates GO:1900584 ! o-orsellinic acid biosynthetic process
created_by: di
creation_date: 2012-05-22T04:56:46Z

[Term]
id: GO:1900699
name: negative regulation of o-orsellinic acid biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of o-orsellinic acid biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of o-orsellinic acid anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of o-orsellinic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of o-orsellinic acid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of o-orsellinic acid formation" EXACT [GOC:TermGenie]
synonym: "down regulation of o-orsellinic acid synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of o-orsellinic acid anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of o-orsellinic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of o-orsellinic acid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of o-orsellinic acid formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of o-orsellinic acid synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of o-orsellinic acid anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of o-orsellinic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of o-orsellinic acid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of o-orsellinic acid formation" EXACT [GOC:TermGenie]
synonym: "downregulation of o-orsellinic acid synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of o-orsellinic acid anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of o-orsellinic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of o-orsellinic acid biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of o-orsellinic acid formation" EXACT [GOC:TermGenie]
synonym: "inhibition of o-orsellinic acid synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of o-orsellinic acid anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of o-orsellinic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of o-orsellinic acid formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of o-orsellinic acid synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900698 ! regulation of o-orsellinic acid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900584 ! o-orsellinic acid biosynthetic process
relationship: negatively_regulates GO:1900584 ! o-orsellinic acid biosynthetic process
created_by: di
creation_date: 2012-05-22T04:57:08Z

[Term]
id: GO:1900700
name: positive regulation of o-orsellinic acid biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of o-orsellinic acid biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of o-orsellinic acid anabolism" EXACT [GOC:TermGenie]
synonym: "activation of o-orsellinic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of o-orsellinic acid biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of o-orsellinic acid formation" EXACT [GOC:TermGenie]
synonym: "activation of o-orsellinic acid synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of o-orsellinic acid anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of o-orsellinic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of o-orsellinic acid formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of o-orsellinic acid synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of o-orsellinic acid anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of o-orsellinic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of o-orsellinic acid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of o-orsellinic acid formation" EXACT [GOC:TermGenie]
synonym: "up regulation of o-orsellinic acid synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of o-orsellinic acid anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of o-orsellinic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of o-orsellinic acid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of o-orsellinic acid formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of o-orsellinic acid synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of o-orsellinic acid anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of o-orsellinic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of o-orsellinic acid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of o-orsellinic acid formation" EXACT [GOC:TermGenie]
synonym: "upregulation of o-orsellinic acid synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900698 ! regulation of o-orsellinic acid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900584 ! o-orsellinic acid biosynthetic process
relationship: positively_regulates GO:1900584 ! o-orsellinic acid biosynthetic process
created_by: di
creation_date: 2012-05-22T04:57:16Z

[Term]
id: GO:1900701
name: regulation of orcinol biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of orcinol biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of orcinol anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of orcinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of orcinol formation" EXACT [GOC:TermGenie]
synonym: "regulation of orcinol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0046197 ! orcinol biosynthetic process
relationship: regulates GO:0046197 ! orcinol biosynthetic process
created_by: di
creation_date: 2012-05-22T04:57:59Z

[Term]
id: GO:1900702
name: negative regulation of orcinol biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of orcinol biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of orcinol anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of orcinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of orcinol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of orcinol formation" EXACT [GOC:TermGenie]
synonym: "down regulation of orcinol synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of orcinol anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of orcinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of orcinol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of orcinol formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of orcinol synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of orcinol anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of orcinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of orcinol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of orcinol formation" EXACT [GOC:TermGenie]
synonym: "downregulation of orcinol synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of orcinol anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of orcinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of orcinol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of orcinol formation" EXACT [GOC:TermGenie]
synonym: "inhibition of orcinol synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of orcinol anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of orcinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of orcinol formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of orcinol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900701 ! regulation of orcinol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0046197 ! orcinol biosynthetic process
relationship: negatively_regulates GO:0046197 ! orcinol biosynthetic process
created_by: di
creation_date: 2012-05-22T04:58:20Z

[Term]
id: GO:1900703
name: positive regulation of orcinol biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of orcinol biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of orcinol anabolism" EXACT [GOC:TermGenie]
synonym: "activation of orcinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of orcinol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of orcinol formation" EXACT [GOC:TermGenie]
synonym: "activation of orcinol synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of orcinol anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of orcinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of orcinol formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of orcinol synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of orcinol anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of orcinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of orcinol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of orcinol formation" EXACT [GOC:TermGenie]
synonym: "up regulation of orcinol synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of orcinol anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of orcinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of orcinol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of orcinol formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of orcinol synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of orcinol anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of orcinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of orcinol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of orcinol formation" EXACT [GOC:TermGenie]
synonym: "upregulation of orcinol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900701 ! regulation of orcinol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0046197 ! orcinol biosynthetic process
relationship: positively_regulates GO:0046197 ! orcinol biosynthetic process
created_by: di
creation_date: 2012-05-22T04:58:28Z

[Term]
id: GO:1900704
name: regulation of siderophore biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of siderophore biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of siderochrome biosynthesis" NARROW [GOC:TermGenie]
synonym: "regulation of siderochrome biosynthetic process" NARROW [GOC:TermGenie]
synonym: "regulation of siderophore anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of siderophore biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of siderophore biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "regulation of siderophore biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "regulation of siderophore formation" EXACT [GOC:TermGenie]
synonym: "regulation of siderophore synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0034248 ! regulation of cellular amide metabolic process
is_a: GO:0051193 ! regulation of cofactor metabolic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019290 ! siderophore biosynthetic process
relationship: regulates GO:0019290 ! siderophore biosynthetic process
created_by: di
creation_date: 2012-05-22T04:59:28Z

[Term]
id: GO:1900705
name: negative regulation of siderophore biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of siderophore biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of siderochrome biosynthesis" NARROW [GOC:TermGenie]
synonym: "down regulation of siderochrome biosynthetic process" NARROW [GOC:TermGenie]
synonym: "down regulation of siderophore anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of siderophore biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of siderophore biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of siderophore biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "down regulation of siderophore biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "down regulation of siderophore formation" EXACT [GOC:TermGenie]
synonym: "down regulation of siderophore synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of siderochrome biosynthesis" NARROW [GOC:TermGenie]
synonym: "down-regulation of siderochrome biosynthetic process" NARROW [GOC:TermGenie]
synonym: "down-regulation of siderophore anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of siderophore biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of siderophore biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of siderophore biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "down-regulation of siderophore biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "down-regulation of siderophore formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of siderophore synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of siderochrome biosynthesis" NARROW [GOC:TermGenie]
synonym: "downregulation of siderochrome biosynthetic process" NARROW [GOC:TermGenie]
synonym: "downregulation of siderophore anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of siderophore biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of siderophore biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of siderophore biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "downregulation of siderophore biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "downregulation of siderophore formation" EXACT [GOC:TermGenie]
synonym: "downregulation of siderophore synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of siderochrome biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of siderochrome biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of siderophore anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of siderophore biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of siderophore biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of siderophore biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "inhibition of siderophore biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "inhibition of siderophore formation" EXACT [GOC:TermGenie]
synonym: "inhibition of siderophore synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of siderochrome biosynthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of siderochrome biosynthetic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of siderophore anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of siderophore biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of siderophore biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of siderophore biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "negative regulation of siderophore formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of siderophore synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0034249 ! negative regulation of cellular amide metabolic process
is_a: GO:0051195 ! negative regulation of cofactor metabolic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900704 ! regulation of siderophore biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019290 ! siderophore biosynthetic process
relationship: negatively_regulates GO:0019290 ! siderophore biosynthetic process
created_by: di
creation_date: 2012-05-22T04:59:49Z

[Term]
id: GO:1900706
name: positive regulation of siderophore biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of siderophore biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of siderochrome biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of siderochrome biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of siderophore anabolism" EXACT [GOC:TermGenie]
synonym: "activation of siderophore biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of siderophore biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of siderophore biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "activation of siderophore biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "activation of siderophore formation" EXACT [GOC:TermGenie]
synonym: "activation of siderophore synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of siderochrome biosynthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of siderochrome biosynthetic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of siderophore anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of siderophore biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of siderophore biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of siderophore biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "positive regulation of siderophore formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of siderophore synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of siderochrome biosynthesis" NARROW [GOC:TermGenie]
synonym: "up regulation of siderochrome biosynthetic process" NARROW [GOC:TermGenie]
synonym: "up regulation of siderophore anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of siderophore biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of siderophore biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of siderophore biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "up regulation of siderophore biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "up regulation of siderophore formation" EXACT [GOC:TermGenie]
synonym: "up regulation of siderophore synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of siderochrome biosynthesis" NARROW [GOC:TermGenie]
synonym: "up-regulation of siderochrome biosynthetic process" NARROW [GOC:TermGenie]
synonym: "up-regulation of siderophore anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of siderophore biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of siderophore biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of siderophore biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "up-regulation of siderophore biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "up-regulation of siderophore formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of siderophore synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of siderochrome biosynthesis" NARROW [GOC:TermGenie]
synonym: "upregulation of siderochrome biosynthetic process" NARROW [GOC:TermGenie]
synonym: "upregulation of siderophore anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of siderophore biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of siderophore biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of siderophore biosynthetic process, peptide formation" NARROW [GOC:TermGenie]
synonym: "upregulation of siderophore biosynthetic process, peptide modification" NARROW [GOC:TermGenie]
synonym: "upregulation of siderophore formation" EXACT [GOC:TermGenie]
synonym: "upregulation of siderophore synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0034250 ! positive regulation of cellular amide metabolic process
is_a: GO:0051194 ! positive regulation of cofactor metabolic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900704 ! regulation of siderophore biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0019290 ! siderophore biosynthetic process
relationship: positively_regulates GO:0019290 ! siderophore biosynthetic process
created_by: di
creation_date: 2012-05-22T05:00:00Z

[Term]
id: GO:1900707
name: regulation of tensidol A biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tensidol A biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of tensidol A anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of tensidol A biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of tensidol A formation" EXACT [GOC:TermGenie]
synonym: "regulation of tensidol A synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900605 ! tensidol A biosynthetic process
relationship: regulates GO:1900605 ! tensidol A biosynthetic process
created_by: di
creation_date: 2012-05-22T05:01:44Z

[Term]
id: GO:1900708
name: negative regulation of tensidol A biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tensidol A biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of tensidol A anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of tensidol A biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of tensidol A biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of tensidol A formation" EXACT [GOC:TermGenie]
synonym: "down regulation of tensidol A synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of tensidol A anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of tensidol A biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of tensidol A biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of tensidol A formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of tensidol A synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of tensidol A anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of tensidol A biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of tensidol A biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of tensidol A formation" EXACT [GOC:TermGenie]
synonym: "downregulation of tensidol A synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of tensidol A anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of tensidol A biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of tensidol A biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of tensidol A formation" EXACT [GOC:TermGenie]
synonym: "inhibition of tensidol A synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of tensidol A anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of tensidol A biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of tensidol A formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of tensidol A synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900707 ! regulation of tensidol A biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900605 ! tensidol A biosynthetic process
relationship: negatively_regulates GO:1900605 ! tensidol A biosynthetic process
created_by: di
creation_date: 2012-05-22T05:02:04Z

[Term]
id: GO:1900709
name: positive regulation of tensidol A biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tensidol A biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of tensidol A anabolism" EXACT [GOC:TermGenie]
synonym: "activation of tensidol A biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of tensidol A biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of tensidol A formation" EXACT [GOC:TermGenie]
synonym: "activation of tensidol A synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of tensidol A anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of tensidol A biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of tensidol A formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of tensidol A synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of tensidol A anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of tensidol A biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of tensidol A biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of tensidol A formation" EXACT [GOC:TermGenie]
synonym: "up regulation of tensidol A synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of tensidol A anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of tensidol A biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of tensidol A biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of tensidol A formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of tensidol A synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of tensidol A anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of tensidol A biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of tensidol A biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of tensidol A formation" EXACT [GOC:TermGenie]
synonym: "upregulation of tensidol A synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900707 ! regulation of tensidol A biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900605 ! tensidol A biosynthetic process
relationship: positively_regulates GO:1900605 ! tensidol A biosynthetic process
created_by: di
creation_date: 2012-05-22T05:02:12Z

[Term]
id: GO:1900710
name: regulation of tensidol B biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tensidol B biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of tensidol B anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of tensidol B biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of tensidol B formation" EXACT [GOC:TermGenie]
synonym: "regulation of tensidol B synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900608 ! tensidol B biosynthetic process
relationship: regulates GO:1900608 ! tensidol B biosynthetic process
created_by: di
creation_date: 2012-05-22T05:02:55Z

[Term]
id: GO:1900711
name: negative regulation of tensidol B biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tensidol B biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of tensidol B anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of tensidol B biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of tensidol B biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of tensidol B formation" EXACT [GOC:TermGenie]
synonym: "down regulation of tensidol B synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of tensidol B anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of tensidol B biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of tensidol B biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of tensidol B formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of tensidol B synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of tensidol B anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of tensidol B biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of tensidol B biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of tensidol B formation" EXACT [GOC:TermGenie]
synonym: "downregulation of tensidol B synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of tensidol B anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of tensidol B biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of tensidol B biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of tensidol B formation" EXACT [GOC:TermGenie]
synonym: "inhibition of tensidol B synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of tensidol B anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of tensidol B biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of tensidol B formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of tensidol B synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900710 ! regulation of tensidol B biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900608 ! tensidol B biosynthetic process
relationship: negatively_regulates GO:1900608 ! tensidol B biosynthetic process
created_by: di
creation_date: 2012-05-22T05:03:16Z

[Term]
id: GO:1900712
name: positive regulation of tensidol B biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tensidol B biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of tensidol B anabolism" EXACT [GOC:TermGenie]
synonym: "activation of tensidol B biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of tensidol B biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of tensidol B formation" EXACT [GOC:TermGenie]
synonym: "activation of tensidol B synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of tensidol B anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of tensidol B biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of tensidol B formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of tensidol B synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of tensidol B anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of tensidol B biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of tensidol B biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of tensidol B formation" EXACT [GOC:TermGenie]
synonym: "up regulation of tensidol B synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of tensidol B anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of tensidol B biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of tensidol B biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of tensidol B formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of tensidol B synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of tensidol B anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of tensidol B biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of tensidol B biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of tensidol B formation" EXACT [GOC:TermGenie]
synonym: "upregulation of tensidol B synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900710 ! regulation of tensidol B biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900608 ! tensidol B biosynthetic process
relationship: positively_regulates GO:1900608 ! tensidol B biosynthetic process
created_by: di
creation_date: 2012-05-22T05:03:23Z

[Term]
id: GO:1900713
name: regulation of violaceol I biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of violaceol I biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of violaceol I anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of violaceol I biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of violaceol I formation" EXACT [GOC:TermGenie]
synonym: "regulation of violaceol I synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900590 ! violaceol I biosynthetic process
relationship: regulates GO:1900590 ! violaceol I biosynthetic process
created_by: di
creation_date: 2012-05-22T05:04:12Z

[Term]
id: GO:1900714
name: negative regulation of violaceol I biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of violaceol I biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of violaceol I anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of violaceol I biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of violaceol I biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of violaceol I formation" EXACT [GOC:TermGenie]
synonym: "down regulation of violaceol I synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of violaceol I anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of violaceol I biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of violaceol I biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of violaceol I formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of violaceol I synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of violaceol I anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of violaceol I biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of violaceol I biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of violaceol I formation" EXACT [GOC:TermGenie]
synonym: "downregulation of violaceol I synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of violaceol I anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of violaceol I biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of violaceol I biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of violaceol I formation" EXACT [GOC:TermGenie]
synonym: "inhibition of violaceol I synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of violaceol I anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of violaceol I biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of violaceol I formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of violaceol I synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900713 ! regulation of violaceol I biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900590 ! violaceol I biosynthetic process
relationship: negatively_regulates GO:1900590 ! violaceol I biosynthetic process
created_by: di
creation_date: 2012-05-22T05:04:33Z

[Term]
id: GO:1900715
name: positive regulation of violaceol I biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of violaceol I biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of violaceol I anabolism" EXACT [GOC:TermGenie]
synonym: "activation of violaceol I biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of violaceol I biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of violaceol I formation" EXACT [GOC:TermGenie]
synonym: "activation of violaceol I synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of violaceol I anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of violaceol I biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of violaceol I formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of violaceol I synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of violaceol I anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of violaceol I biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of violaceol I biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of violaceol I formation" EXACT [GOC:TermGenie]
synonym: "up regulation of violaceol I synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of violaceol I anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of violaceol I biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of violaceol I biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of violaceol I formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of violaceol I synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of violaceol I anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of violaceol I biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of violaceol I biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of violaceol I formation" EXACT [GOC:TermGenie]
synonym: "upregulation of violaceol I synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900713 ! regulation of violaceol I biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900590 ! violaceol I biosynthetic process
relationship: positively_regulates GO:1900590 ! violaceol I biosynthetic process
created_by: di
creation_date: 2012-05-22T05:04:41Z

[Term]
id: GO:1900716
name: regulation of violaceol II biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of violaceol II biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of violaceol II anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of violaceol II biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of violaceol II formation" EXACT [GOC:TermGenie]
synonym: "regulation of violaceol II synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900593 ! violaceol II biosynthetic process
relationship: regulates GO:1900593 ! violaceol II biosynthetic process
created_by: di
creation_date: 2012-05-22T05:05:37Z

[Term]
id: GO:1900717
name: negative regulation of violaceol II biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of violaceol II biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of violaceol II anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of violaceol II biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of violaceol II biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of violaceol II formation" EXACT [GOC:TermGenie]
synonym: "down regulation of violaceol II synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of violaceol II anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of violaceol II biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of violaceol II biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of violaceol II formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of violaceol II synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of violaceol II anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of violaceol II biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of violaceol II biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of violaceol II formation" EXACT [GOC:TermGenie]
synonym: "downregulation of violaceol II synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of violaceol II anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of violaceol II biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of violaceol II biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of violaceol II formation" EXACT [GOC:TermGenie]
synonym: "inhibition of violaceol II synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of violaceol II anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of violaceol II biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of violaceol II formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of violaceol II synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900716 ! regulation of violaceol II biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900593 ! violaceol II biosynthetic process
relationship: negatively_regulates GO:1900593 ! violaceol II biosynthetic process
created_by: di
creation_date: 2012-05-22T05:05:58Z

[Term]
id: GO:1900718
name: positive regulation of violaceol II biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of violaceol II biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of violaceol II anabolism" EXACT [GOC:TermGenie]
synonym: "activation of violaceol II biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of violaceol II biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of violaceol II formation" EXACT [GOC:TermGenie]
synonym: "activation of violaceol II synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of violaceol II anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of violaceol II biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of violaceol II formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of violaceol II synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of violaceol II anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of violaceol II biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of violaceol II biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of violaceol II formation" EXACT [GOC:TermGenie]
synonym: "up regulation of violaceol II synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of violaceol II anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of violaceol II biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of violaceol II biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of violaceol II formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of violaceol II synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of violaceol II anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of violaceol II biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of violaceol II biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of violaceol II formation" EXACT [GOC:TermGenie]
synonym: "upregulation of violaceol II synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900716 ! regulation of violaceol II biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900593 ! violaceol II biosynthetic process
relationship: positively_regulates GO:1900593 ! violaceol II biosynthetic process
created_by: di
creation_date: 2012-05-22T05:06:06Z

[Term]
id: GO:1900719
name: regulation of uterine smooth muscle relaxation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of uterine smooth muscle relaxation." [GOC:TermGenie]
synonym: "regulation of smooth muscle relaxation of the uterus" EXACT [GOC:TermGenie]
is_a: GO:1901080 ! regulation of relaxation of smooth muscle
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044558 ! uterine smooth muscle relaxation
relationship: regulates GO:0044558 ! uterine smooth muscle relaxation
created_by: jl
creation_date: 2012-05-24T03:12:26Z

[Term]
id: GO:1900720
name: negative regulation of uterine smooth muscle relaxation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of uterine smooth muscle relaxation." [GOC:TermGenie]
synonym: "down regulation of smooth muscle relaxation of the uterus" EXACT [GOC:TermGenie]
synonym: "down regulation of uterine smooth muscle relaxation" EXACT [GOC:TermGenie]
synonym: "down-regulation of smooth muscle relaxation of the uterus" EXACT [GOC:TermGenie]
synonym: "down-regulation of uterine smooth muscle relaxation" EXACT [GOC:TermGenie]
synonym: "downregulation of smooth muscle relaxation of the uterus" EXACT [GOC:TermGenie]
synonym: "downregulation of uterine smooth muscle relaxation" EXACT [GOC:TermGenie]
synonym: "inhibition of smooth muscle relaxation of the uterus" EXACT [GOC:TermGenie]
synonym: "inhibition of uterine smooth muscle relaxation" NARROW [GOC:TermGenie]
synonym: "negative regulation of smooth muscle relaxation of the uterus" EXACT [GOC:TermGenie]
is_a: GO:1900719 ! regulation of uterine smooth muscle relaxation
is_a: GO:1901081 ! negative regulation of relaxation of smooth muscle
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044558 ! uterine smooth muscle relaxation
relationship: negatively_regulates GO:0044558 ! uterine smooth muscle relaxation
created_by: jl
creation_date: 2012-05-24T03:12:49Z

[Term]
id: GO:1900721
name: positive regulation of uterine smooth muscle relaxation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of uterine smooth muscle relaxation." [GOC:TermGenie]
synonym: "activation of smooth muscle relaxation of the uterus" EXACT [GOC:TermGenie]
synonym: "activation of uterine smooth muscle relaxation" NARROW [GOC:TermGenie]
synonym: "positive regulation of smooth muscle relaxation of the uterus" EXACT [GOC:TermGenie]
synonym: "up regulation of smooth muscle relaxation of the uterus" EXACT [GOC:TermGenie]
synonym: "up regulation of uterine smooth muscle relaxation" EXACT [GOC:TermGenie]
synonym: "up-regulation of smooth muscle relaxation of the uterus" EXACT [GOC:TermGenie]
synonym: "up-regulation of uterine smooth muscle relaxation" EXACT [GOC:TermGenie]
synonym: "upregulation of smooth muscle relaxation of the uterus" EXACT [GOC:TermGenie]
synonym: "upregulation of uterine smooth muscle relaxation" EXACT [GOC:TermGenie]
is_a: GO:1900719 ! regulation of uterine smooth muscle relaxation
is_a: GO:1901082 ! positive regulation of relaxation of smooth muscle
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044558 ! uterine smooth muscle relaxation
relationship: positively_regulates GO:0044558 ! uterine smooth muscle relaxation
created_by: jl
creation_date: 2012-05-24T03:12:57Z

[Term]
id: GO:1900722
name: regulation of protein adenylylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein adenylylation." [GOC:TermGenie]
synonym: "regulation of protein adenylation" EXACT [GOC:TermGenie]
synonym: "regulation of protein amino acid adenylylation" EXACT [GOC:TermGenie]
synonym: "regulation of protein AMPylation" EXACT [GOC:TermGenie]
is_a: GO:0031399 ! regulation of protein modification process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0018117 ! protein adenylylation
relationship: regulates GO:0018117 ! protein adenylylation
created_by: jl
creation_date: 2012-05-24T03:15:44Z

[Term]
id: GO:1900723
name: negative regulation of protein adenylylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein adenylylation." [GOC:TermGenie]
synonym: "down regulation of protein adenylation" EXACT [GOC:TermGenie]
synonym: "down regulation of protein adenylylation" EXACT [GOC:TermGenie]
synonym: "down regulation of protein amino acid adenylylation" EXACT [GOC:TermGenie]
synonym: "down regulation of protein AMPylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein adenylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein adenylylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein amino acid adenylylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein AMPylation" EXACT [GOC:TermGenie]
synonym: "downregulation of protein adenylation" EXACT [GOC:TermGenie]
synonym: "downregulation of protein adenylylation" EXACT [GOC:TermGenie]
synonym: "downregulation of protein amino acid adenylylation" EXACT [GOC:TermGenie]
synonym: "downregulation of protein AMPylation" EXACT [GOC:TermGenie]
synonym: "inhibition of protein adenylation" EXACT [GOC:TermGenie]
synonym: "inhibition of protein adenylylation" NARROW [GOC:TermGenie]
synonym: "inhibition of protein amino acid adenylylation" EXACT [GOC:TermGenie]
synonym: "inhibition of protein AMPylation" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein adenylation" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein amino acid adenylylation" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein AMPylation" EXACT [GOC:TermGenie]
is_a: GO:0031400 ! negative regulation of protein modification process
is_a: GO:1900722 ! regulation of protein adenylylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0018117 ! protein adenylylation
relationship: negatively_regulates GO:0018117 ! protein adenylylation
created_by: jl
creation_date: 2012-05-24T03:16:06Z

[Term]
id: GO:1900724
name: positive regulation of protein adenylylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein adenylylation." [GOC:TermGenie]
synonym: "activation of protein adenylation" EXACT [GOC:TermGenie]
synonym: "activation of protein adenylylation" NARROW [GOC:TermGenie]
synonym: "activation of protein amino acid adenylylation" EXACT [GOC:TermGenie]
synonym: "activation of protein AMPylation" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein adenylation" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein amino acid adenylylation" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein AMPylation" EXACT [GOC:TermGenie]
synonym: "up regulation of protein adenylation" EXACT [GOC:TermGenie]
synonym: "up regulation of protein adenylylation" EXACT [GOC:TermGenie]
synonym: "up regulation of protein amino acid adenylylation" EXACT [GOC:TermGenie]
synonym: "up regulation of protein AMPylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein adenylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein adenylylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein amino acid adenylylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein AMPylation" EXACT [GOC:TermGenie]
synonym: "upregulation of protein adenylation" EXACT [GOC:TermGenie]
synonym: "upregulation of protein adenylylation" EXACT [GOC:TermGenie]
synonym: "upregulation of protein amino acid adenylylation" EXACT [GOC:TermGenie]
synonym: "upregulation of protein AMPylation" EXACT [GOC:TermGenie]
is_a: GO:0031401 ! positive regulation of protein modification process
is_a: GO:1900722 ! regulation of protein adenylylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0018117 ! protein adenylylation
relationship: positively_regulates GO:0018117 ! protein adenylylation
created_by: jl
creation_date: 2012-05-24T03:16:13Z

[Term]
id: GO:1900725
name: osmoregulated periplasmic glucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving osmoregulated periplasmic glucan." [GOC:TermGenie, GOC:yaf]
synonym: "osmoregulated periplasmic glucan metabolism" EXACT [GOC:TermGenie]
is_a: GO:0044042 ! glucan metabolic process
created_by: jl
creation_date: 2012-05-24T03:18:32Z

[Term]
id: GO:1900726
name: osmoregulated periplasmic glucan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of osmoregulated periplasmic glucan." [GOC:TermGenie, GOC:yaf]
synonym: "osmoregulated periplasmic glucan breakdown" EXACT [GOC:TermGenie]
synonym: "osmoregulated periplasmic glucan catabolism" EXACT [GOC:TermGenie]
synonym: "osmoregulated periplasmic glucan degradation" EXACT [GOC:TermGenie]
is_a: GO:0009251 ! glucan catabolic process
is_a: GO:1900725 ! osmoregulated periplasmic glucan metabolic process
created_by: jl
creation_date: 2012-05-24T03:18:54Z

[Term]
id: GO:1900727
name: osmoregulated periplasmic glucan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of osmoregulated periplasmic glucan." [GOC:TermGenie, GOC:yaf]
synonym: "osmoregulated periplasmic glucan anabolism" EXACT [GOC:TermGenie]
synonym: "osmoregulated periplasmic glucan biosynthesis" EXACT [GOC:TermGenie]
synonym: "osmoregulated periplasmic glucan formation" EXACT [GOC:TermGenie]
synonym: "osmoregulated periplasmic glucan synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009250 ! glucan biosynthetic process
is_a: GO:1900725 ! osmoregulated periplasmic glucan metabolic process
created_by: jl
creation_date: 2012-05-24T03:19:02Z

[Term]
id: GO:1900728
name: cardiac neural crest cell delamination involved in outflow tract morphogenesis
namespace: biological_process
def: "Any cardiac neural crest cell delamination that is involved in outflow tract morphogenesis." [GOC:hjd, GOC:TermGenie, PMID:18539270]
is_a: GO:0036036 ! cardiac neural crest cell delamination
intersection_of: GO:0036036 ! cardiac neural crest cell delamination
intersection_of: part_of GO:0003151 ! outflow tract morphogenesis
relationship: part_of GO:0003151 ! outflow tract morphogenesis
created_by: bf
creation_date: 2012-05-25T09:50:24Z

[Term]
id: GO:1900729
name: regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of adenylate cyclase-inhibiting opioid receptor signaling pathway." [GOC:sjw, GOC:TermGenie, PMID:17157995]
synonym: "regulation of inhibition of adenylate cyclase activity by opioid receptor" RELATED [PMID:17157995]
synonym: "regulation of inhibition of adenylate cyclase activity by opioid receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "regulation of inhibition of adenylate cyclase activity by opioid receptor signalling pathway" RELATED [GOC:TermGenie]
synonym: "regulation of opioid receptor-mediated adenylate cyclase inhibition" RELATED []
is_a: GO:2000474 ! regulation of opioid receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031635 ! adenylate cyclase-inhibiting opioid receptor signaling pathway
relationship: regulates GO:0031635 ! adenylate cyclase-inhibiting opioid receptor signaling pathway
created_by: bf
creation_date: 2012-05-25T03:20:49Z

[Term]
id: GO:1900730
name: negative regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of adenylate cyclase-inhibiting opioid receptor signaling pathway." [GOC:sjw, GOC:TermGenie, PMID:17157995]
synonym: "down regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of adenylate cyclase-inhibiting opioid receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of adenylate cyclase-inhibiting opioid receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of opioid receptor-mediated adenylate cyclase inhibition" RELATED []
synonym: "negative regulation of inhibition of adenylate cyclase activity by opioid receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of inhibition of adenylate cyclase activity by opioid receptor signalling pathway" RELATED [GOC:TermGenie]
is_a: GO:1900729 ! regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway
is_a: GO:2000475 ! negative regulation of opioid receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0031635 ! adenylate cyclase-inhibiting opioid receptor signaling pathway
relationship: negatively_regulates GO:0031635 ! adenylate cyclase-inhibiting opioid receptor signaling pathway
created_by: bf
creation_date: 2012-05-25T03:21:12Z

[Term]
id: GO:1900731
name: positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of adenylate cyclase-inhibiting opioid receptor signaling pathway." [GOC:sjw, GOC:TermGenie, PMID:17157995]
synonym: "activation of adenylate cyclase-inhibiting opioid receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of opioid receptor-mediated adenylate cyclase inhibition" RELATED []
synonym: "up regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of adenylate cyclase-inhibiting opioid receptor signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:1900729 ! regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway
is_a: GO:2000476 ! positive regulation of opioid receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0031635 ! adenylate cyclase-inhibiting opioid receptor signaling pathway
relationship: positively_regulates GO:0031635 ! adenylate cyclase-inhibiting opioid receptor signaling pathway
created_by: bf
creation_date: 2012-05-25T03:21:19Z

[Term]
id: GO:1900732
name: regulation of polyketide biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of polyketide biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of polyketide anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of polyketide biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of polyketide formation" EXACT [GOC:TermGenie]
synonym: "regulation of polyketide synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010566 ! regulation of ketone biosynthetic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030639 ! polyketide biosynthetic process
relationship: regulates GO:0030639 ! polyketide biosynthetic process
created_by: di
creation_date: 2012-05-26T01:29:40Z

[Term]
id: GO:1900733
name: negative regulation of polyketide biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of polyketide biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of polyketide anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of polyketide biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of polyketide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of polyketide formation" EXACT [GOC:TermGenie]
synonym: "down regulation of polyketide synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of polyketide anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of polyketide biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of polyketide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of polyketide formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of polyketide synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of polyketide anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of polyketide biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of polyketide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of polyketide formation" EXACT [GOC:TermGenie]
synonym: "downregulation of polyketide synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of polyketide anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of polyketide biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of polyketide biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of polyketide formation" EXACT [GOC:TermGenie]
synonym: "inhibition of polyketide synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of polyketide anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of polyketide biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of polyketide formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of polyketide synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900732 ! regulation of polyketide biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030639 ! polyketide biosynthetic process
relationship: negatively_regulates GO:0030639 ! polyketide biosynthetic process
created_by: di
creation_date: 2012-05-26T01:30:02Z

[Term]
id: GO:1900734
name: positive regulation of polyketide biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of polyketide biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of polyketide anabolism" EXACT [GOC:TermGenie]
synonym: "activation of polyketide biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of polyketide biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of polyketide formation" EXACT [GOC:TermGenie]
synonym: "activation of polyketide synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of polyketide anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of polyketide biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of polyketide formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of polyketide synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of polyketide anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of polyketide biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of polyketide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of polyketide formation" EXACT [GOC:TermGenie]
synonym: "up regulation of polyketide synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of polyketide anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of polyketide biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of polyketide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of polyketide formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of polyketide synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of polyketide anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of polyketide biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of polyketide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of polyketide formation" EXACT [GOC:TermGenie]
synonym: "upregulation of polyketide synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900732 ! regulation of polyketide biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030639 ! polyketide biosynthetic process
relationship: positively_regulates GO:0030639 ! polyketide biosynthetic process
created_by: di
creation_date: 2012-05-26T01:30:10Z

[Term]
id: GO:1900735
name: positive regulation of flocculation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of flocculation." [GOC:di, GOC:TermGenie]
synonym: "activation of flocculation" NARROW [GOC:TermGenie]
synonym: "up regulation of flocculation" EXACT [GOC:TermGenie]
synonym: "up-regulation of flocculation" EXACT [GOC:TermGenie]
synonym: "upregulation of flocculation" EXACT [GOC:TermGenie]
is_a: GO:0043902 ! positive regulation of multi-organism process
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0060256 ! regulation of flocculation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000128 ! flocculation
relationship: positively_regulates GO:0000128 ! flocculation
created_by: di
creation_date: 2012-05-27T08:27:38Z

[Term]
id: GO:1900736
name: regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phospholipase C-activating G-protein coupled receptor signaling pathway." [GOC:BHF, GOC:TermGenie]
synonym: "regulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger" RELATED [GOC:TermGenie]
synonym: "regulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "regulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "regulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger" EXACT [GOC:TermGenie]
synonym: "regulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "regulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "regulation of phospholipase C-activating dopamine receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "regulation of PLC-activating GPCR signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007200 ! phospholipase C-activating G-protein coupled receptor signaling pathway
relationship: regulates GO:0007200 ! phospholipase C-activating G-protein coupled receptor signaling pathway
created_by: rl
creation_date: 2012-05-28T10:07:27Z

[Term]
id: GO:1900737
name: negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of phospholipase C-activating G-protein coupled receptor signaling pathway." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger" RELATED [GOC:TermGenie]
synonym: "down regulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "down regulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "down regulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger" EXACT [GOC:TermGenie]
synonym: "down regulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "down regulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "down regulation of phospholipase C-activating dopamine receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "down regulation of phospholipase C-activating G-protein coupled receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of PLC-activating GPCR signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger" RELATED [GOC:TermGenie]
synonym: "down-regulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "down-regulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "down-regulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger" EXACT [GOC:TermGenie]
synonym: "down-regulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "down-regulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "down-regulation of phospholipase C-activating dopamine receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "down-regulation of phospholipase C-activating G-protein coupled receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of PLC-activating GPCR signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger" RELATED [GOC:TermGenie]
synonym: "downregulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "downregulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "downregulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger" EXACT [GOC:TermGenie]
synonym: "downregulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "downregulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "downregulation of phospholipase C-activating dopamine receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "downregulation of phospholipase C-activating G-protein coupled receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of PLC-activating GPCR signaling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger" RELATED [GOC:TermGenie]
synonym: "inhibition of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "inhibition of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "inhibition of G-protein coupled receptor signaling pathway coupled to IP3 second messenger" EXACT [GOC:TermGenie]
synonym: "inhibition of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "inhibition of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "inhibition of phospholipase C-activating dopamine receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of phospholipase C-activating G-protein coupled receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of PLC-activating GPCR signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger" RELATED [GOC:TermGenie]
synonym: "negative regulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "negative regulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "negative regulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger" EXACT [GOC:TermGenie]
synonym: "negative regulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "negative regulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "negative regulation of phospholipase C-activating dopamine receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of PLC-activating GPCR signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0045744 ! negative regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:1900736 ! regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007200 ! phospholipase C-activating G-protein coupled receptor signaling pathway
relationship: negatively_regulates GO:0007200 ! phospholipase C-activating G-protein coupled receptor signaling pathway
created_by: rl
creation_date: 2012-05-28T10:07:48Z

[Term]
id: GO:1900738
name: positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phospholipase C-activating G-protein coupled receptor signaling pathway." [GOC:BHF, GOC:TermGenie]
synonym: "activation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger" RELATED [GOC:TermGenie]
synonym: "activation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "activation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "activation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger" EXACT [GOC:TermGenie]
synonym: "activation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "activation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "activation of phospholipase C-activating dopamine receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of phospholipase C-activating G-protein coupled receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of PLC-activating GPCR signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger" RELATED [GOC:TermGenie]
synonym: "positive regulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "positive regulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "positive regulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger" EXACT [GOC:TermGenie]
synonym: "positive regulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "positive regulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "positive regulation of phospholipase C-activating dopamine receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of PLC-activating GPCR signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger" RELATED [GOC:TermGenie]
synonym: "up regulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "up regulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "up regulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger" EXACT [GOC:TermGenie]
synonym: "up regulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "up regulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "up regulation of phospholipase C-activating dopamine receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "up regulation of phospholipase C-activating G-protein coupled receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of PLC-activating GPCR signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger" RELATED [GOC:TermGenie]
synonym: "up-regulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "up-regulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "up-regulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger" EXACT [GOC:TermGenie]
synonym: "up-regulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "up-regulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "up-regulation of phospholipase C-activating dopamine receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "up-regulation of phospholipase C-activating G-protein coupled receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of PLC-activating GPCR signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger" RELATED [GOC:TermGenie]
synonym: "upregulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "upregulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "upregulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger" EXACT [GOC:TermGenie]
synonym: "upregulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "upregulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie]
synonym: "upregulation of phospholipase C-activating dopamine receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "upregulation of phospholipase C-activating G-protein coupled receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of PLC-activating GPCR signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0045745 ! positive regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:1900736 ! regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007200 ! phospholipase C-activating G-protein coupled receptor signaling pathway
relationship: positively_regulates GO:0007200 ! phospholipase C-activating G-protein coupled receptor signaling pathway
created_by: rl
creation_date: 2012-05-28T10:07:56Z

[Term]
id: GO:1900739
name: regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway." [GOC:mtg_apoptosis, GOC:TermGenie]
synonym: "regulation of insertion of proteins into mitochondrial membranes during the induction of apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of protein insertion into mitochondrial membrane during induction of apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of protein insertion into mitochondrial membrane involved in induction of apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of protein insertion into mitochondrion membrane during induction of apoptosis" NARROW [GOC:TermGenie]
is_a: GO:1901028 ! regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
is_a: GO:1903747 ! regulation of establishment of protein localization to mitochondrion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001844 ! protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
relationship: regulates GO:0001844 ! protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
created_by: pr
creation_date: 2012-05-28T02:28:18Z

[Term]
id: GO:1900740
name: positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway." [GOC:mtg_apoptosis, GOC:TermGenie]
synonym: "activation of insertion of proteins into mitochondrial membranes during the induction of apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of protein insertion into mitochondrial membrane during induction of apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of protein insertion into mitochondrial membrane involved in induction of apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of protein insertion into mitochondrion membrane during induction of apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of insertion of proteins into mitochondrial membranes during the induction of apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein insertion into mitochondrial membrane during induction of apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein insertion into mitochondrial membrane involved in induction of apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein insertion into mitochondrion membrane during induction of apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of insertion of proteins into mitochondrial membranes during the induction of apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of protein insertion into mitochondrial membrane during induction of apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of protein insertion into mitochondrial membrane involved in induction of apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of protein insertion into mitochondrion membrane during induction of apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of insertion of proteins into mitochondrial membranes during the induction of apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of protein insertion into mitochondrial membrane during induction of apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein insertion into mitochondrial membrane involved in induction of apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of protein insertion into mitochondrion membrane during induction of apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of insertion of proteins into mitochondrial membranes during the induction of apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of protein insertion into mitochondrial membrane during induction of apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of protein insertion into mitochondrial membrane involved in induction of apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of protein insertion into mitochondrion membrane during induction of apoptosis" NARROW [GOC:TermGenie]
is_a: GO:1900739 ! regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
is_a: GO:1901030 ! positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
is_a: GO:1903749 ! positive regulation of establishment of protein localization to mitochondrion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001844 ! protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
relationship: positively_regulates GO:0001844 ! protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
created_by: pr
creation_date: 2012-05-28T02:28:40Z

[Term]
id: GO:1900741
name: regulation of filamentous growth of a population of unicellular organisms in response to pH
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to pH." [GOC:di, GOC:TermGenie]
is_a: GO:0048583 ! regulation of response to stimulus
is_a: GO:1900428 ! regulation of filamentous growth of a population of unicellular organisms
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0036177 ! filamentous growth of a population of unicellular organisms in response to pH
relationship: regulates GO:0036177 ! filamentous growth of a population of unicellular organisms in response to pH
created_by: di
creation_date: 2012-05-28T02:34:39Z

[Term]
id: GO:1900742
name: negative regulation of filamentous growth of a population of unicellular organisms in response to pH
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to pH." [GOC:di, GOC:TermGenie]
synonym: "down regulation of filamentous growth of a population of unicellular organisms in response to pH" EXACT [GOC:TermGenie]
synonym: "down-regulation of filamentous growth of a population of unicellular organisms in response to pH" EXACT [GOC:TermGenie]
synonym: "downregulation of filamentous growth of a population of unicellular organisms in response to pH" EXACT [GOC:TermGenie]
synonym: "inhibition of filamentous growth of a population of unicellular organisms in response to pH" NARROW [GOC:TermGenie]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1900429 ! negative regulation of filamentous growth of a population of unicellular organisms
is_a: GO:1900741 ! regulation of filamentous growth of a population of unicellular organisms in response to pH
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0036177 ! filamentous growth of a population of unicellular organisms in response to pH
relationship: negatively_regulates GO:0036177 ! filamentous growth of a population of unicellular organisms in response to pH
created_by: di
creation_date: 2012-05-28T02:35:03Z

[Term]
id: GO:1900743
name: positive regulation of filamentous growth of a population of unicellular organisms in response to pH
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to pH." [GOC:di, GOC:TermGenie]
synonym: "activation of filamentous growth of a population of unicellular organisms in response to pH" NARROW [GOC:TermGenie]
synonym: "up regulation of filamentous growth of a population of unicellular organisms in response to pH" EXACT [GOC:TermGenie]
synonym: "up-regulation of filamentous growth of a population of unicellular organisms in response to pH" EXACT [GOC:TermGenie]
synonym: "upregulation of filamentous growth of a population of unicellular organisms in response to pH" EXACT [GOC:TermGenie]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1900430 ! positive regulation of filamentous growth of a population of unicellular organisms
is_a: GO:1900741 ! regulation of filamentous growth of a population of unicellular organisms in response to pH
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0036177 ! filamentous growth of a population of unicellular organisms in response to pH
relationship: positively_regulates GO:0036177 ! filamentous growth of a population of unicellular organisms in response to pH
created_by: di
creation_date: 2012-05-28T02:35:11Z

[Term]
id: GO:1900744
name: regulation of p38MAPK cascade
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of p38MAPK cascade." [GOC:TermGenie]
synonym: "regulation of p38 cascade" EXACT [GOC:TermGenie]
synonym: "regulation of p38 MAPK cascade" EXACT [GOC:TermGenie]
is_a: GO:0032872 ! regulation of stress-activated MAPK cascade
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0038066 ! p38MAPK cascade
relationship: regulates GO:0038066 ! p38MAPK cascade
created_by: pm
creation_date: 2012-05-28T02:40:14Z

[Term]
id: GO:1900745
name: positive regulation of p38MAPK cascade
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of p38MAPK cascade." [GOC:TermGenie]
synonym: "activation of p38 cascade" EXACT [GOC:TermGenie]
synonym: "activation of p38 MAPK cascade" EXACT [GOC:TermGenie]
synonym: "activation of p38MAPK cascade" NARROW [GOC:TermGenie]
synonym: "positive regulation of p38 cascade" EXACT [GOC:TermGenie]
synonym: "positive regulation of p38 MAPK cascade" EXACT [GOC:TermGenie]
synonym: "up regulation of p38 cascade" EXACT [GOC:TermGenie]
synonym: "up regulation of p38 MAPK cascade" EXACT [GOC:TermGenie]
synonym: "up regulation of p38MAPK cascade" EXACT [GOC:TermGenie]
synonym: "up-regulation of p38 cascade" EXACT [GOC:TermGenie]
synonym: "up-regulation of p38 MAPK cascade" EXACT [GOC:TermGenie]
synonym: "up-regulation of p38MAPK cascade" EXACT [GOC:TermGenie]
synonym: "upregulation of p38 cascade" EXACT [GOC:TermGenie]
synonym: "upregulation of p38 MAPK cascade" EXACT [GOC:TermGenie]
synonym: "upregulation of p38MAPK cascade" EXACT [GOC:TermGenie]
is_a: GO:0032874 ! positive regulation of stress-activated MAPK cascade
is_a: GO:1900744 ! regulation of p38MAPK cascade
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0038066 ! p38MAPK cascade
relationship: positively_regulates GO:0038066 ! p38MAPK cascade
created_by: pm
creation_date: 2012-05-28T02:40:48Z

[Term]
id: GO:1900746
name: regulation of vascular endothelial growth factor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vascular endothelial growth factor signaling pathway." [GOC:TermGenie]
synonym: "regulation of vascular endothelial growth factor signalling pathway" EXACT [GOC:TermGenie]
synonym: "regulation of VEGF signaling" EXACT [GOC:TermGenie]
synonym: "regulation of VEGF-activated signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:1902547 ! regulation of cellular response to vascular endothelial growth factor stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0038084 ! vascular endothelial growth factor signaling pathway
relationship: regulates GO:0038084 ! vascular endothelial growth factor signaling pathway
created_by: pm
creation_date: 2012-05-29T08:28:06Z

[Term]
id: GO:1900747
name: negative regulation of vascular endothelial growth factor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial growth factor signaling pathway." [GOC:TermGenie]
synonym: "down regulation of vascular endothelial growth factor signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of vascular endothelial growth factor signalling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of VEGF signaling" EXACT [GOC:TermGenie]
synonym: "down regulation of VEGF-activated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of vascular endothelial growth factor signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of vascular endothelial growth factor signalling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of VEGF signaling" EXACT [GOC:TermGenie]
synonym: "down-regulation of VEGF-activated signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of vascular endothelial growth factor signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of vascular endothelial growth factor signalling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of VEGF signaling" EXACT [GOC:TermGenie]
synonym: "downregulation of VEGF-activated signaling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of vascular endothelial growth factor signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of vascular endothelial growth factor signalling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of VEGF signaling" EXACT [GOC:TermGenie]
synonym: "inhibition of VEGF-activated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of vascular endothelial growth factor signalling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of VEGF signaling" EXACT [GOC:TermGenie]
synonym: "negative regulation of VEGF-activated signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:1900746 ! regulation of vascular endothelial growth factor signaling pathway
is_a: GO:1902548 ! negative regulation of cellular response to vascular endothelial growth factor stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0038084 ! vascular endothelial growth factor signaling pathway
relationship: negatively_regulates GO:0038084 ! vascular endothelial growth factor signaling pathway
created_by: pm
creation_date: 2012-05-29T08:28:29Z

[Term]
id: GO:1900748
name: positive regulation of vascular endothelial growth factor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vascular endothelial growth factor signaling pathway." [GOC:TermGenie]
synonym: "activation of vascular endothelial growth factor signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of vascular endothelial growth factor signalling pathway" EXACT [GOC:TermGenie]
synonym: "activation of VEGF signaling" EXACT [GOC:TermGenie]
synonym: "activation of VEGF-activated signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of vascular endothelial growth factor signalling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of VEGF signaling" EXACT [GOC:TermGenie]
synonym: "positive regulation of VEGF-activated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of vascular endothelial growth factor signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of vascular endothelial growth factor signalling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of VEGF signaling" EXACT [GOC:TermGenie]
synonym: "up regulation of VEGF-activated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of vascular endothelial growth factor signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of vascular endothelial growth factor signalling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of VEGF signaling" EXACT [GOC:TermGenie]
synonym: "up-regulation of VEGF-activated signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of vascular endothelial growth factor signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of vascular endothelial growth factor signalling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of VEGF signaling" EXACT [GOC:TermGenie]
synonym: "upregulation of VEGF-activated signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:1900746 ! regulation of vascular endothelial growth factor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0038084 ! vascular endothelial growth factor signaling pathway
relationship: positively_regulates GO:0038084 ! vascular endothelial growth factor signaling pathway
created_by: pm
creation_date: 2012-05-29T08:28:36Z

[Term]
id: GO:1900749
name: (R)-carnitine transport
namespace: biological_process
def: "The directed movement of a (R)-carnitine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:TermGenie, PMID:16365044, PMID:20357772, PMID:20829798]
synonym: "(-)-Carnitine transport" RELATED [GOC:TermGenie]
synonym: "(-)-L-Carnitine transport" RELATED [GOC:TermGenie]
synonym: "(3R)-3-hydroxy-4-(trimethylammonio)butanoate transport" EXACT [GOC:TermGenie]
synonym: "(R)-Carnitine transport" EXACT [GOC:TermGenie]
synonym: "C7H15NO3 transport" RELATED [GOC:TermGenie]
synonym: "Carnicor transport" RELATED [GOC:TermGenie]
synonym: "Carnitene transport" RELATED [GOC:TermGenie]
synonym: "Carnitine transport" RELATED [GOC:TermGenie]
synonym: "Carnitor transport" RELATED [GOC:TermGenie]
synonym: "L-Carnitine transport" EXACT [GOC:TermGenie]
synonym: "Levocarnitine transport" RELATED [GOC:TermGenie]
synonym: "Vitamin BT transport" RELATED [GOC:TermGenie]
is_a: GO:0015879 ! carnitine transport
created_by: jl
creation_date: 2012-05-29T02:01:17Z

[Term]
id: GO:1900750
name: oligopeptide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an oligopeptide." [GOC:TermGenie, PMID:21854595]
synonym: "Oligopeptid binding" RELATED [GOC:TermGenie]
synonym: "oligopeptides binding" EXACT [GOC:TermGenie]
synonym: "oligopeptido binding" RELATED [GOC:TermGenie]
is_a: GO:0042277 ! peptide binding
created_by: jl
creation_date: 2012-05-29T02:13:31Z

[Term]
id: GO:1900751
name: 4-(trimethylammonio)butanoate transport
namespace: biological_process
def: "The directed movement of a 4-(trimethylammonio)butanoate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:TermGenie, PMID:16365044, PMID:20357772, PMID:20829798]
synonym: "4-(N-trimethylamino)butyrate transport" EXACT [GOC:TermGenie]
synonym: "4-butyrobetaine transport" EXACT [GOC:TermGenie]
synonym: "Actinine transport" RELATED [GOC:TermGenie]
synonym: "butyrobetaine transport" RELATED [GOC:TermGenie]
synonym: "C7H15NO2 transport" RELATED [GOC:TermGenie]
synonym: "deoxycarnitine transport" RELATED [GOC:TermGenie]
synonym: "gamma-Butyrobetain transport" EXACT [GOC:TermGenie]
synonym: "gamma-butyrobetaine transport" EXACT [GOC:TermGenie]
is_a: GO:0015696 ! ammonium transport
is_a: GO:0015838 ! amino-acid betaine transport
created_by: jl
creation_date: 2012-05-29T02:32:37Z

[Term]
id: GO:1900752
name: malonic acid transport
namespace: biological_process
def: "The directed movement of a malonic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:TermGenie, PMID:9128730, PMID:9573154]
synonym: "C3H4O4 transport" RELATED [GOC:TermGenie]
synonym: "H2malo transport" RELATED [GOC:TermGenie]
synonym: "HOOC-CH2-COOH transport" RELATED [GOC:TermGenie]
synonym: "propanedioic acid transport" EXACT [GOC:TermGenie]
is_a: GO:0006835 ! dicarboxylic acid transport
created_by: jl
creation_date: 2012-05-29T02:40:33Z

[Term]
id: GO:1900753
name: doxorubicin transport
namespace: biological_process
def: "The directed movement of a doxorubicin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:TermGenie, PMID:12057006, PMID:15090538, PMID:19063901, PMID:19651502, PMID:9651400]
synonym: "(1S,3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside transport" EXACT [GOC:TermGenie]
synonym: "(1S,3S)-3-glycoloyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside transport" RELATED [GOC:TermGenie]
synonym: "(8S-cis)-10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione transport" RELATED [GOC:TermGenie]
synonym: "14-hydroxydaunomycin transport" RELATED [GOC:TermGenie]
synonym: "14-hydroxydaunorubicine transport" RELATED [GOC:TermGenie]
synonym: "Adriamycin transport" RELATED [GOC:TermGenie]
synonym: "doxorubicine transport" RELATED [GOC:TermGenie]
synonym: "doxorubicinum transport" RELATED [GOC:TermGenie]
is_a: GO:0015695 ! organic cation transport
is_a: GO:0015696 ! ammonium transport
is_a: GO:1901656 ! glycoside transport
created_by: jl
creation_date: 2012-05-29T02:50:43Z

[Term]
id: GO:1900754
name: 4-hydroxyphenylacetate transport
namespace: biological_process
def: "The directed movement of a 4-hydroxyphenylacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:TermGenie, PMID:9315705]
synonym: "(4-hydroxyphenyl)acetate transport" EXACT [GOC:TermGenie]
synonym: "(p-hydroxyphenyl)acetate transport" EXACT [GOC:TermGenie]
synonym: "2-(4-hydroxyphenyl)ethanoate transport" EXACT [GOC:TermGenie]
synonym: "4-hydroxybenzeneacetate transport" EXACT [GOC:TermGenie]
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0015850 ! organic hydroxy compound transport
created_by: jl
creation_date: 2012-05-29T02:59:02Z

[Term]
id: GO:1900756
name: protein processing in phagocytic vesicle
namespace: biological_process
def: "Protein processing that takes place in the phagosome. Most protein processing in the phagosome represents protein degradation." [GOC:rjd, GOC:TermGenie]
synonym: "peptidolysis during protein maturation in phagocytic vesicle" RELATED [GOC:TermGenie]
synonym: "peptidolysis during protein maturation in phagosome" RELATED [GOC:TermGenie]
synonym: "protein maturation by peptide bond cleavage in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "protein maturation by peptide bond cleavage in phagosome" EXACT [GOC:TermGenie]
synonym: "protein maturation by peptide bond hydrolysis in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "protein maturation by peptide bond hydrolysis in phagosome" EXACT [GOC:TermGenie]
synonym: "protein maturation by proteolysis in phagocytic vesicle" RELATED [GOC:TermGenie]
synonym: "protein maturation by proteolysis in phagosome" RELATED [GOC:TermGenie]
synonym: "protein processing in phagosome" EXACT [GOC:TermGenie]
is_a: GO:0016485 ! protein processing
intersection_of: GO:0016485 ! protein processing
intersection_of: occurs_in GO:0045335 ! phagocytic vesicle
relationship: occurs_in GO:0045335 ! phagocytic vesicle
created_by: rjd
creation_date: 2012-05-29T09:55:14Z

[Term]
id: GO:1900757
name: regulation of D-amino-acid oxidase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of D-amino-acid oxidase activity." [GOC:TermGenie]
synonym: "regulation of D-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [GOC:TermGenie]
synonym: "regulation of L-amino acid:O2 oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of new yellow enzyme" RELATED [GOC:TermGenie]
is_a: GO:0051341 ! regulation of oxidoreductase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003884 ! D-amino-acid oxidase activity
relationship: regulates GO:0003884 ! D-amino-acid oxidase activity
created_by: pm
creation_date: 2012-05-31T11:23:45Z

[Term]
id: GO:1900758
name: negative regulation of D-amino-acid oxidase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of D-amino-acid oxidase activity." [GOC:TermGenie]
synonym: "down regulation of D-amino-acid oxidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of D-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [GOC:TermGenie]
synonym: "down regulation of L-amino acid:O2 oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of new yellow enzyme" RELATED [GOC:TermGenie]
synonym: "down-regulation of D-amino-acid oxidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of D-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [GOC:TermGenie]
synonym: "down-regulation of L-amino acid:O2 oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of new yellow enzyme" RELATED [GOC:TermGenie]
synonym: "downregulation of D-amino-acid oxidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of D-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [GOC:TermGenie]
synonym: "downregulation of L-amino acid:O2 oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of new yellow enzyme" RELATED [GOC:TermGenie]
synonym: "inhibition of D-amino-acid oxidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of D-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [GOC:TermGenie]
synonym: "inhibition of L-amino acid:O2 oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of new yellow enzyme" RELATED [GOC:TermGenie]
synonym: "negative regulation of D-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [GOC:TermGenie]
synonym: "negative regulation of L-amino acid:O2 oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of new yellow enzyme" RELATED [GOC:TermGenie]
is_a: GO:0051354 ! negative regulation of oxidoreductase activity
is_a: GO:1900757 ! regulation of D-amino-acid oxidase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003884 ! D-amino-acid oxidase activity
relationship: negatively_regulates GO:0003884 ! D-amino-acid oxidase activity
created_by: pm
creation_date: 2012-05-31T11:24:06Z

[Term]
id: GO:1900759
name: positive regulation of D-amino-acid oxidase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of D-amino-acid oxidase activity." [GOC:TermGenie]
synonym: "activation of D-amino-acid oxidase activity" NARROW [GOC:TermGenie]
synonym: "activation of D-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [GOC:TermGenie]
synonym: "activation of L-amino acid:O2 oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "activation of new yellow enzyme" RELATED [GOC:TermGenie]
synonym: "positive regulation of D-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [GOC:TermGenie]
synonym: "positive regulation of L-amino acid:O2 oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of new yellow enzyme" RELATED [GOC:TermGenie]
synonym: "up regulation of D-amino-acid oxidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of D-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [GOC:TermGenie]
synonym: "up regulation of L-amino acid:O2 oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of new yellow enzyme" RELATED [GOC:TermGenie]
synonym: "up-regulation of D-amino-acid oxidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of D-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-amino acid:O2 oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of new yellow enzyme" RELATED [GOC:TermGenie]
synonym: "upregulation of D-amino-acid oxidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of D-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [GOC:TermGenie]
synonym: "upregulation of L-amino acid:O2 oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of new yellow enzyme" RELATED [GOC:TermGenie]
is_a: GO:0051353 ! positive regulation of oxidoreductase activity
is_a: GO:1900757 ! regulation of D-amino-acid oxidase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003884 ! D-amino-acid oxidase activity
relationship: positively_regulates GO:0003884 ! D-amino-acid oxidase activity
created_by: pm
creation_date: 2012-05-31T11:24:14Z

[Term]
id: GO:1900760
name: negative regulation of sterigmatocystin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sterigmatocystin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of sterigmatocystin anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of sterigmatocystin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of sterigmatocystin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of sterigmatocystin formation" EXACT [GOC:TermGenie]
synonym: "down regulation of sterigmatocystin synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of sterigmatocystin anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of sterigmatocystin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of sterigmatocystin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of sterigmatocystin formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of sterigmatocystin synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of sterigmatocystin anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of sterigmatocystin biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of sterigmatocystin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of sterigmatocystin formation" EXACT [GOC:TermGenie]
synonym: "downregulation of sterigmatocystin synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of sterigmatocystin anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of sterigmatocystin biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of sterigmatocystin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of sterigmatocystin formation" EXACT [GOC:TermGenie]
synonym: "inhibition of sterigmatocystin synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of sterigmatocystin anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of sterigmatocystin biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of sterigmatocystin formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of sterigmatocystin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010913 ! regulation of sterigmatocystin biosynthetic process
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045461 ! sterigmatocystin biosynthetic process
relationship: negatively_regulates GO:0045461 ! sterigmatocystin biosynthetic process
created_by: di
creation_date: 2012-06-04T08:38:30Z

[Term]
id: GO:1900761
name: averantin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving averantin." [GOC:di, GOC:TermGenie]
synonym: "averantin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0030638 ! polyketide metabolic process
is_a: GO:1901661 ! quinone metabolic process
created_by: di
creation_date: 2012-06-04T09:14:22Z

[Term]
id: GO:1900762
name: averantin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of averantin." [GOC:di, GOC:TermGenie]
synonym: "averantin breakdown" EXACT [GOC:TermGenie]
synonym: "averantin catabolism" EXACT [GOC:TermGenie]
synonym: "averantin degradation" EXACT [GOC:TermGenie]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0030640 ! polyketide catabolic process
is_a: GO:1900761 ! averantin metabolic process
is_a: GO:1901662 ! quinone catabolic process
created_by: di
creation_date: 2012-06-04T09:14:45Z

[Term]
id: GO:1900763
name: averantin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of averantin." [GOC:di, GOC:TermGenie]
synonym: "averantin anabolism" EXACT [GOC:TermGenie]
synonym: "averantin biosynthesis" EXACT [GOC:TermGenie]
synonym: "averantin formation" EXACT [GOC:TermGenie]
synonym: "averantin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0030639 ! polyketide biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:1900761 ! averantin metabolic process
is_a: GO:1901663 ! quinone biosynthetic process
created_by: di
creation_date: 2012-06-04T09:14:52Z

[Term]
id: GO:1900764
name: emericellin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving emericellin." [GOC:di, GOC:TermGenie]
synonym: "emericellin metabolism" EXACT [GOC:TermGenie]
synonym: "Variecoxanthone B metabolic process" RELATED [GOC:TermGenie]
synonym: "Variecoxanthone B metabolism" RELATED [GOC:TermGenie]
is_a: GO:0018904 ! ether metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:2001305 ! xanthone-containing compound metabolic process
created_by: di
creation_date: 2012-06-04T09:17:58Z

[Term]
id: GO:1900765
name: emericellin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of emericellin." [GOC:di, GOC:TermGenie]
synonym: "emericellin breakdown" EXACT [GOC:TermGenie]
synonym: "emericellin catabolism" EXACT [GOC:TermGenie]
synonym: "emericellin degradation" EXACT [GOC:TermGenie]
synonym: "Variecoxanthone B breakdown" RELATED [GOC:TermGenie]
synonym: "Variecoxanthone B catabolic process" RELATED [GOC:TermGenie]
synonym: "Variecoxanthone B catabolism" RELATED [GOC:TermGenie]
synonym: "Variecoxanthone B degradation" RELATED [GOC:TermGenie]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900764 ! emericellin metabolic process
is_a: GO:1901502 ! ether catabolic process
created_by: di
creation_date: 2012-06-04T09:18:22Z

[Term]
id: GO:1900766
name: emericellin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of emericellin." [GOC:di, GOC:TermGenie]
synonym: "emericellin anabolism" EXACT [GOC:TermGenie]
synonym: "emericellin biosynthesis" EXACT [GOC:TermGenie]
synonym: "emericellin formation" EXACT [GOC:TermGenie]
synonym: "emericellin synthesis" EXACT [GOC:TermGenie]
synonym: "Variecoxanthone B anabolism" RELATED [GOC:TermGenie]
synonym: "Variecoxanthone B biosynthesis" RELATED [GOC:TermGenie]
synonym: "Variecoxanthone B biosynthetic process" RELATED [GOC:TermGenie]
synonym: "Variecoxanthone B formation" RELATED [GOC:TermGenie]
synonym: "Variecoxanthone B synthesis" RELATED [GOC:TermGenie]
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:1900764 ! emericellin metabolic process
is_a: GO:1901503 ! ether biosynthetic process
is_a: GO:2001307 ! xanthone-containing compound biosynthetic process
created_by: di
creation_date: 2012-06-04T09:18:29Z

[Term]
id: GO:1900767
name: fonsecin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fonsecin." [GOC:di, GOC:TermGenie]
synonym: "fonsecin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:1900785 ! naphtho-gamma-pyrone metabolic process
created_by: di
creation_date: 2012-06-04T09:21:14Z

[Term]
id: GO:1900768
name: fonsecin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of fonsecin." [GOC:di, GOC:TermGenie]
synonym: "fonsecin breakdown" EXACT [GOC:TermGenie]
synonym: "fonsecin catabolism" EXACT [GOC:TermGenie]
synonym: "fonsecin degradation" EXACT [GOC:TermGenie]
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900767 ! fonsecin metabolic process
is_a: GO:1900786 ! naphtho-gamma-pyrone catabolic process
created_by: di
creation_date: 2012-06-04T09:21:38Z

[Term]
id: GO:1900769
name: fonsecin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of fonsecin." [GOC:di, GOC:TermGenie]
synonym: "fonsecin anabolism" EXACT [GOC:TermGenie]
synonym: "fonsecin biosynthesis" EXACT [GOC:TermGenie]
synonym: "fonsecin formation" EXACT [GOC:TermGenie]
synonym: "fonsecin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:1900767 ! fonsecin metabolic process
is_a: GO:1900787 ! naphtho-gamma-pyrone biosynthetic process
created_by: di
creation_date: 2012-06-04T09:21:49Z

[Term]
id: GO:1900770
name: fumitremorgin B metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fumitremorgin B." [GOC:di, GOC:TermGenie]
synonym: "fumitremorgin B metabolism" EXACT [GOC:TermGenie]
synonym: "Lanosulin metabolic process" RELATED [GOC:TermGenie]
synonym: "Lanosulin metabolism" RELATED [GOC:TermGenie]
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0035834 ! indole alkaloid metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:1901376 ! organic heteropentacyclic compound metabolic process
created_by: di
creation_date: 2012-06-04T09:25:18Z

[Term]
id: GO:1900771
name: fumitremorgin B catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of fumitremorgin B." [GOC:di, GOC:TermGenie]
synonym: "fumitremorgin B breakdown" EXACT [GOC:TermGenie]
synonym: "fumitremorgin B catabolism" EXACT [GOC:TermGenie]
synonym: "fumitremorgin B degradation" EXACT [GOC:TermGenie]
synonym: "Lanosulin breakdown" RELATED [GOC:TermGenie]
synonym: "Lanosulin catabolic process" RELATED [GOC:TermGenie]
synonym: "Lanosulin catabolism" RELATED [GOC:TermGenie]
synonym: "Lanosulin degradation" RELATED [GOC:TermGenie]
is_a: GO:0009822 ! alkaloid catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900770 ! fumitremorgin B metabolic process
is_a: GO:1901377 ! organic heteropentacyclic compound catabolic process
created_by: di
creation_date: 2012-06-04T09:25:43Z

[Term]
id: GO:1900772
name: fumitremorgin B biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of fumitremorgin B." [GOC:di, GOC:TermGenie]
synonym: "fumitremorgin B anabolism" EXACT [GOC:TermGenie]
synonym: "fumitremorgin B biosynthesis" EXACT [GOC:TermGenie]
synonym: "fumitremorgin B formation" EXACT [GOC:TermGenie]
synonym: "fumitremorgin B synthesis" EXACT [GOC:TermGenie]
synonym: "Lanosulin anabolism" RELATED [GOC:TermGenie]
synonym: "Lanosulin biosynthesis" RELATED [GOC:TermGenie]
synonym: "Lanosulin biosynthetic process" RELATED [GOC:TermGenie]
synonym: "Lanosulin formation" RELATED [GOC:TermGenie]
synonym: "Lanosulin synthesis" RELATED [GOC:TermGenie]
is_a: GO:0035835 ! indole alkaloid biosynthetic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:1900770 ! fumitremorgin B metabolic process
is_a: GO:1901378 ! organic heteropentacyclic compound biosynthetic process
created_by: di
creation_date: 2012-06-04T09:25:50Z

[Term]
id: GO:1900773
name: fumiquinazoline metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fumiquinazoline." [GOC:di, GOC:TermGenie]
synonym: "fumiquinazoline metabolism" EXACT [GOC:TermGenie]
synonym: "fumiquinazolines metabolic process" RELATED [GOC:TermGenie]
synonym: "fumiquinazolines metabolism" RELATED [GOC:TermGenie]
is_a: GO:0035834 ! indole alkaloid metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
created_by: di
creation_date: 2012-06-04T09:29:22Z

[Term]
id: GO:1900774
name: fumiquinazoline catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of fumiquinazoline." [GOC:di, GOC:TermGenie]
synonym: "fumiquinazoline breakdown" EXACT [GOC:TermGenie]
synonym: "fumiquinazoline catabolism" EXACT [GOC:TermGenie]
synonym: "fumiquinazoline degradation" EXACT [GOC:TermGenie]
synonym: "fumiquinazolines breakdown" RELATED [GOC:TermGenie]
synonym: "fumiquinazolines catabolic process" RELATED [GOC:TermGenie]
synonym: "fumiquinazolines catabolism" RELATED [GOC:TermGenie]
synonym: "fumiquinazolines degradation" RELATED [GOC:TermGenie]
is_a: GO:0009822 ! alkaloid catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1900773 ! fumiquinazoline metabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
created_by: di
creation_date: 2012-06-04T09:29:46Z

[Term]
id: GO:1900775
name: fumiquinazoline biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of fumiquinazoline." [GOC:di, GOC:TermGenie]
synonym: "fumiquinazoline anabolism" EXACT [GOC:TermGenie]
synonym: "fumiquinazoline biosynthesis" EXACT [GOC:TermGenie]
synonym: "fumiquinazoline formation" EXACT [GOC:TermGenie]
synonym: "fumiquinazoline synthesis" EXACT [GOC:TermGenie]
synonym: "fumiquinazolines anabolism" RELATED [GOC:TermGenie]
synonym: "fumiquinazolines biosynthesis" RELATED [GOC:TermGenie]
synonym: "fumiquinazolines biosynthetic process" RELATED [GOC:TermGenie]
synonym: "fumiquinazolines formation" RELATED [GOC:TermGenie]
synonym: "fumiquinazolines synthesis" RELATED [GOC:TermGenie]
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0035835 ! indole alkaloid biosynthetic process
is_a: GO:1900773 ! fumiquinazoline metabolic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
created_by: di
creation_date: 2012-06-04T09:29:54Z

[Term]
id: GO:1900776
name: fumiquinazoline A metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fumiquinazoline A." [GOC:di, GOC:TermGenie]
synonym: "fumiquinazoline A metabolism" EXACT [GOC:TermGenie]
is_a: GO:1900773 ! fumiquinazoline metabolic process
created_by: di
creation_date: 2012-06-04T09:29:58Z

[Term]
id: GO:1900777
name: fumiquinazoline A catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of fumiquinazoline A." [GOC:di, GOC:TermGenie]
synonym: "fumiquinazoline A breakdown" EXACT [GOC:TermGenie]
synonym: "fumiquinazoline A catabolism" EXACT [GOC:TermGenie]
synonym: "fumiquinazoline A degradation" EXACT [GOC:TermGenie]
is_a: GO:1900774 ! fumiquinazoline catabolic process
is_a: GO:1900776 ! fumiquinazoline A metabolic process
created_by: di
creation_date: 2012-06-04T09:30:18Z

[Term]
id: GO:1900778
name: fumiquinazoline A biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of fumiquinazoline A." [GOC:di, GOC:TermGenie]
synonym: "fumiquinazoline A anabolism" EXACT [GOC:TermGenie]
synonym: "fumiquinazoline A biosynthesis" EXACT [GOC:TermGenie]
synonym: "fumiquinazoline A formation" EXACT [GOC:TermGenie]
synonym: "fumiquinazoline A synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900775 ! fumiquinazoline biosynthetic process
is_a: GO:1900776 ! fumiquinazoline A metabolic process
created_by: di
creation_date: 2012-06-04T09:30:25Z

[Term]
id: GO:1900779
name: fumiquinazoline C metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fumiquinazoline C." [GOC:di, GOC:TermGenie]
synonym: "fumiquinazoline C metabolism" EXACT [GOC:TermGenie]
is_a: GO:1900773 ! fumiquinazoline metabolic process
created_by: di
creation_date: 2012-06-04T09:30:30Z

[Term]
id: GO:1900780
name: fumiquinazoline C catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of fumiquinazoline C." [GOC:di, GOC:TermGenie]
synonym: "fumiquinazoline C breakdown" EXACT [GOC:TermGenie]
synonym: "fumiquinazoline C catabolism" EXACT [GOC:TermGenie]
synonym: "fumiquinazoline C degradation" EXACT [GOC:TermGenie]
is_a: GO:1900774 ! fumiquinazoline catabolic process
is_a: GO:1900779 ! fumiquinazoline C metabolic process
created_by: di
creation_date: 2012-06-04T09:30:51Z

[Term]
id: GO:1900781
name: fumiquinazoline C biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of fumiquinazoline C." [GOC:di, GOC:TermGenie]
synonym: "fumiquinazoline C anabolism" EXACT [GOC:TermGenie]
synonym: "fumiquinazoline C biosynthesis" EXACT [GOC:TermGenie]
synonym: "fumiquinazoline C formation" EXACT [GOC:TermGenie]
synonym: "fumiquinazoline C synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900775 ! fumiquinazoline biosynthetic process
is_a: GO:1900779 ! fumiquinazoline C metabolic process
created_by: di
creation_date: 2012-06-04T09:30:58Z

[Term]
id: GO:1900782
name: fumiquinazoline F metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fumiquinazoline F." [GOC:di, GOC:TermGenie]
synonym: "fumiquinazoline F metabolism" EXACT [GOC:TermGenie]
is_a: GO:0042430 ! indole-containing compound metabolic process
is_a: GO:1900773 ! fumiquinazoline metabolic process
created_by: di
creation_date: 2012-06-04T09:31:06Z

[Term]
id: GO:1900783
name: fumiquinazoline F catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of fumiquinazoline F." [GOC:di, GOC:TermGenie]
synonym: "fumiquinazoline F breakdown" EXACT [GOC:TermGenie]
synonym: "fumiquinazoline F catabolism" EXACT [GOC:TermGenie]
synonym: "fumiquinazoline F degradation" EXACT [GOC:TermGenie]
is_a: GO:0042436 ! indole-containing compound catabolic process
is_a: GO:1900774 ! fumiquinazoline catabolic process
is_a: GO:1900782 ! fumiquinazoline F metabolic process
created_by: di
creation_date: 2012-06-04T09:31:27Z

[Term]
id: GO:1900784
name: fumiquinazoline F biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of fumiquinazoline F." [GOC:di, GOC:TermGenie]
synonym: "fumiquinazoline F anabolism" EXACT [GOC:TermGenie]
synonym: "fumiquinazoline F biosynthesis" EXACT [GOC:TermGenie]
synonym: "fumiquinazoline F formation" EXACT [GOC:TermGenie]
synonym: "fumiquinazoline F synthesis" EXACT [GOC:TermGenie]
is_a: GO:0042435 ! indole-containing compound biosynthetic process
is_a: GO:1900775 ! fumiquinazoline biosynthetic process
is_a: GO:1900782 ! fumiquinazoline F metabolic process
created_by: di
creation_date: 2012-06-04T09:31:34Z

[Term]
id: GO:1900785
name: naphtho-gamma-pyrone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving naphtho-gamma-pyrone." [GOC:di, GOC:TermGenie]
synonym: "naphtho-gamma-pyrone metabolism" EXACT [GOC:TermGenie]
synonym: "naphtho-gamma-pyrones metabolic process" RELATED [GOC:TermGenie]
synonym: "naphtho-gamma-pyrones metabolism" RELATED [GOC:TermGenie]
is_a: GO:0042180 ! cellular ketone metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
created_by: di
creation_date: 2012-06-04T09:35:32Z

[Term]
id: GO:1900786
name: naphtho-gamma-pyrone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of naphtho-gamma-pyrone." [GOC:di, GOC:TermGenie]
synonym: "naphtho-gamma-pyrone breakdown" EXACT [GOC:TermGenie]
synonym: "naphtho-gamma-pyrone catabolism" EXACT [GOC:TermGenie]
synonym: "naphtho-gamma-pyrone degradation" EXACT [GOC:TermGenie]
synonym: "naphtho-gamma-pyrones breakdown" RELATED [GOC:TermGenie]
synonym: "naphtho-gamma-pyrones catabolic process" RELATED [GOC:TermGenie]
synonym: "naphtho-gamma-pyrones catabolism" RELATED [GOC:TermGenie]
synonym: "naphtho-gamma-pyrones degradation" RELATED [GOC:TermGenie]
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1900785 ! naphtho-gamma-pyrone metabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
created_by: di
creation_date: 2012-06-04T09:35:54Z

[Term]
id: GO:1900787
name: naphtho-gamma-pyrone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of naphtho-gamma-pyrone." [GOC:di, GOC:TermGenie]
synonym: "naphtho-gamma-pyrone anabolism" EXACT [GOC:TermGenie]
synonym: "naphtho-gamma-pyrone biosynthesis" EXACT [GOC:TermGenie]
synonym: "naphtho-gamma-pyrone formation" EXACT [GOC:TermGenie]
synonym: "naphtho-gamma-pyrone synthesis" EXACT [GOC:TermGenie]
synonym: "naphtho-gamma-pyrones anabolism" RELATED [GOC:TermGenie]
synonym: "naphtho-gamma-pyrones biosynthesis" RELATED [GOC:TermGenie]
synonym: "naphtho-gamma-pyrones biosynthetic process" RELATED [GOC:TermGenie]
synonym: "naphtho-gamma-pyrones formation" RELATED [GOC:TermGenie]
synonym: "naphtho-gamma-pyrones synthesis" RELATED [GOC:TermGenie]
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:1900785 ! naphtho-gamma-pyrone metabolic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
created_by: di
creation_date: 2012-06-04T09:36:02Z

[Term]
id: GO:1900788
name: pseurotin A metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pseurotin A." [GOC:di, GOC:TermGenie]
synonym: "pseurotin A metabolism" EXACT [GOC:TermGenie]
synonym: "Pseurotin metabolic process" RELATED [GOC:TermGenie]
synonym: "Pseurotin metabolism" RELATED [GOC:TermGenie]
is_a: GO:0043603 ! cellular amide metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process
created_by: di
creation_date: 2012-06-04T09:37:18Z

[Term]
id: GO:1900789
name: pseurotin A catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pseurotin A." [GOC:di, GOC:TermGenie]
synonym: "pseurotin A breakdown" EXACT [GOC:TermGenie]
synonym: "pseurotin A catabolism" EXACT [GOC:TermGenie]
synonym: "pseurotin A degradation" EXACT [GOC:TermGenie]
synonym: "Pseurotin breakdown" RELATED [GOC:TermGenie]
synonym: "Pseurotin catabolic process" RELATED [GOC:TermGenie]
synonym: "Pseurotin catabolism" RELATED [GOC:TermGenie]
synonym: "Pseurotin degradation" RELATED [GOC:TermGenie]
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1900788 ! pseurotin A metabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process
created_by: di
creation_date: 2012-06-04T09:37:41Z

[Term]
id: GO:1900790
name: pseurotin A biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pseurotin A." [GOC:di, GOC:TermGenie]
synonym: "pseurotin A anabolism" EXACT [GOC:TermGenie]
synonym: "pseurotin A biosynthesis" EXACT [GOC:TermGenie]
synonym: "pseurotin A formation" EXACT [GOC:TermGenie]
synonym: "pseurotin A synthesis" EXACT [GOC:TermGenie]
synonym: "Pseurotin anabolism" RELATED [GOC:TermGenie]
synonym: "Pseurotin biosynthesis" RELATED [GOC:TermGenie]
synonym: "Pseurotin biosynthetic process" RELATED [GOC:TermGenie]
synonym: "Pseurotin formation" RELATED [GOC:TermGenie]
synonym: "Pseurotin synthesis" RELATED [GOC:TermGenie]
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process
is_a: GO:1900788 ! pseurotin A metabolic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process
created_by: di
creation_date: 2012-06-04T09:37:49Z

[Term]
id: GO:1900791
name: shamixanthone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving shamixanthone." [GOC:di, GOC:TermGenie]
synonym: "shamixanthone metabolism" EXACT [GOC:TermGenie]
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0042180 ! cellular ketone metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
created_by: di
creation_date: 2012-06-04T09:40:20Z

[Term]
id: GO:1900792
name: shamixanthone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of shamixanthone." [GOC:di, GOC:TermGenie]
synonym: "shamixanthone breakdown" EXACT [GOC:TermGenie]
synonym: "shamixanthone catabolism" EXACT [GOC:TermGenie]
synonym: "shamixanthone degradation" EXACT [GOC:TermGenie]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900791 ! shamixanthone metabolic process
created_by: di
creation_date: 2012-06-04T09:40:42Z

[Term]
id: GO:1900793
name: shamixanthone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of shamixanthone." [GOC:di, GOC:TermGenie]
synonym: "shamixanthone anabolism" EXACT [GOC:TermGenie]
synonym: "shamixanthone biosynthesis" EXACT [GOC:TermGenie]
synonym: "shamixanthone formation" EXACT [GOC:TermGenie]
synonym: "shamixanthone synthesis" EXACT [GOC:TermGenie]
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:1900791 ! shamixanthone metabolic process
created_by: di
creation_date: 2012-06-04T09:40:49Z

[Term]
id: GO:1900794
name: terrequinone A metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving terrequinone A." [GOC:di, GOC:TermGenie]
synonym: "terrequinone A metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009820 ! alkaloid metabolic process
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901661 ! quinone metabolic process
created_by: di
creation_date: 2012-06-04T09:45:20Z

[Term]
id: GO:1900795
name: terrequinone A catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of terrequinone A." [GOC:di, GOC:TermGenie]
synonym: "terrequinone A breakdown" EXACT [GOC:TermGenie]
synonym: "terrequinone A catabolism" EXACT [GOC:TermGenie]
synonym: "terrequinone A degradation" EXACT [GOC:TermGenie]
is_a: GO:0009822 ! alkaloid catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900794 ! terrequinone A metabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901662 ! quinone catabolic process
created_by: di
creation_date: 2012-06-04T09:45:41Z

[Term]
id: GO:1900796
name: terrequinone A biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of terrequinone A." [GOC:di, GOC:TermGenie]
synonym: "terrequinone A anabolism" EXACT [GOC:TermGenie]
synonym: "terrequinone A biosynthesis" EXACT [GOC:TermGenie]
synonym: "terrequinone A formation" EXACT [GOC:TermGenie]
synonym: "terrequinone A synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009821 ! alkaloid biosynthetic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:1900794 ! terrequinone A metabolic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901663 ! quinone biosynthetic process
created_by: di
creation_date: 2012-06-04T09:45:48Z

[Term]
id: GO:1900797
name: cordyol C metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cordyol C." [GOC:di, GOC:TermGenie]
synonym: "cordyol C metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009712 ! catechol-containing compound metabolic process
is_a: GO:0018904 ! ether metabolic process
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0044763 ! single-organism cellular process
created_by: di
creation_date: 2012-06-04T09:47:48Z

[Term]
id: GO:1900798
name: cordyol C catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cordyol C." [GOC:di, GOC:TermGenie]
synonym: "cordyol C breakdown" EXACT [GOC:TermGenie]
synonym: "cordyol C catabolism" EXACT [GOC:TermGenie]
synonym: "cordyol C degradation" EXACT [GOC:TermGenie]
is_a: GO:0019614 ! catechol-containing compound catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900797 ! cordyol C metabolic process
is_a: GO:1901502 ! ether catabolic process
created_by: di
creation_date: 2012-06-04T09:48:10Z

[Term]
id: GO:1900799
name: cordyol C biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cordyol C." [GOC:di, GOC:TermGenie]
synonym: "cordyol C anabolism" EXACT [GOC:TermGenie]
synonym: "cordyol C biosynthesis" EXACT [GOC:TermGenie]
synonym: "cordyol C formation" EXACT [GOC:TermGenie]
synonym: "cordyol C synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009713 ! catechol-containing compound biosynthetic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:1900797 ! cordyol C metabolic process
is_a: GO:1901503 ! ether biosynthetic process
created_by: di
creation_date: 2012-06-04T09:48:17Z

[Term]
id: GO:1900800
name: cspyrone B1 metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cspyrone B1." [GOC:di, GOC:TermGenie]
synonym: "cspyrone B1 metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042180 ! cellular ketone metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
created_by: di
creation_date: 2012-06-04T09:50:37Z

[Term]
id: GO:1900801
name: cspyrone B1 catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cspyrone B1." [GOC:di, GOC:TermGenie]
synonym: "cspyrone B1 breakdown" EXACT [GOC:TermGenie]
synonym: "cspyrone B1 catabolism" EXACT [GOC:TermGenie]
synonym: "cspyrone B1 degradation" EXACT [GOC:TermGenie]
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900800 ! cspyrone B1 metabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
created_by: di
creation_date: 2012-06-04T09:50:58Z

[Term]
id: GO:1900802
name: cspyrone B1 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cspyrone B1." [GOC:di, GOC:TermGenie]
synonym: "cspyrone B1 anabolism" EXACT [GOC:TermGenie]
synonym: "cspyrone B1 biosynthesis" EXACT [GOC:TermGenie]
synonym: "cspyrone B1 formation" EXACT [GOC:TermGenie]
synonym: "cspyrone B1 synthesis" EXACT [GOC:TermGenie]
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:1900800 ! cspyrone B1 metabolic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
created_by: di
creation_date: 2012-06-04T09:51:06Z

[Term]
id: GO:1900803
name: brevianamide F metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving brevianamide F." [GOC:di, GOC:TermGenie]
synonym: "brevianamide F metabolism" EXACT [GOC:TermGenie]
synonym: "cyclo-(Trp-Pro) metabolism" RELATED [GOC:TermGenie]
synonym: "cyclo-L-Trp-L-Pro metabolic process" RELATED [GOC:TermGenie]
synonym: "cyclo-L-Trp-L-Pro metabolism" RELATED [GOC:TermGenie]
synonym: "cyclo-L-tryptophanyl-L-proline metabolic process" RELATED [GOC:TermGenie]
synonym: "cyclo-L-tryptophanyl-L-proline metabolism" RELATED [GOC:TermGenie]
synonym: "L-prolyl-L-tryptophan anhydride metabolic process" RELATED [GOC:TermGenie]
synonym: "L-prolyl-L-tryptophan anhydride metabolism" RELATED [GOC:TermGenie]
synonym: "L-tryptophyl-L-proline cyclic anhydride metabolic process" RELATED [GOC:TermGenie]
synonym: "L-tryptophyl-L-proline cyclic anhydride metabolism" RELATED [GOC:TermGenie]
synonym: "tryptophan-proline diketopiperazine metabolic process" RELATED [GOC:TermGenie]
synonym: "tryptophan-proline diketopiperazine metabolism" RELATED [GOC:TermGenie]
is_a: GO:0006518 ! peptide metabolic process
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0042430 ! indole-containing compound metabolic process
is_a: GO:0044763 ! single-organism cellular process
created_by: di
creation_date: 2012-06-04T09:52:19Z

[Term]
id: GO:1900804
name: brevianamide F catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of brevianamide F." [GOC:di, GOC:TermGenie]
synonym: "brevianamide F breakdown" EXACT [GOC:TermGenie]
synonym: "brevianamide F catabolism" EXACT [GOC:TermGenie]
synonym: "brevianamide F degradation" EXACT [GOC:TermGenie]
synonym: "cyclo-(Trp-Pro) breakdown" RELATED [GOC:TermGenie]
synonym: "cyclo-(Trp-Pro) catabolic process" RELATED [GOC:TermGenie]
synonym: "cyclo-(Trp-Pro) catabolism" RELATED [GOC:TermGenie]
synonym: "cyclo-(Trp-Pro) degradation" RELATED [GOC:TermGenie]
synonym: "cyclo-L-Trp-L-Pro breakdown" RELATED [GOC:TermGenie]
synonym: "cyclo-L-Trp-L-Pro catabolic process" RELATED [GOC:TermGenie]
synonym: "cyclo-L-Trp-L-Pro catabolism" RELATED [GOC:TermGenie]
synonym: "cyclo-L-Trp-L-Pro degradation" RELATED [GOC:TermGenie]
synonym: "cyclo-L-tryptophanyl-L-proline breakdown" RELATED [GOC:TermGenie]
synonym: "cyclo-L-tryptophanyl-L-proline catabolic process" RELATED [GOC:TermGenie]
synonym: "cyclo-L-tryptophanyl-L-proline catabolism" RELATED [GOC:TermGenie]
synonym: "cyclo-L-tryptophanyl-L-proline degradation" RELATED [GOC:TermGenie]
synonym: "L-prolyl-L-tryptophan anhydride breakdown" RELATED [GOC:TermGenie]
synonym: "L-prolyl-L-tryptophan anhydride catabolic process" RELATED [GOC:TermGenie]
synonym: "L-prolyl-L-tryptophan anhydride catabolism" RELATED [GOC:TermGenie]
synonym: "L-prolyl-L-tryptophan anhydride degradation" RELATED [GOC:TermGenie]
synonym: "L-tryptophyl-L-proline cyclic anhydride breakdown" RELATED [GOC:TermGenie]
synonym: "L-tryptophyl-L-proline cyclic anhydride catabolic process" RELATED [GOC:TermGenie]
synonym: "L-tryptophyl-L-proline cyclic anhydride catabolism" RELATED [GOC:TermGenie]
synonym: "L-tryptophyl-L-proline cyclic anhydride degradation" RELATED [GOC:TermGenie]
synonym: "tryptophan-proline diketopiperazine breakdown" RELATED [GOC:TermGenie]
synonym: "tryptophan-proline diketopiperazine catabolic process" RELATED [GOC:TermGenie]
synonym: "tryptophan-proline diketopiperazine catabolism" RELATED [GOC:TermGenie]
synonym: "tryptophan-proline diketopiperazine degradation" RELATED [GOC:TermGenie]
is_a: GO:0042436 ! indole-containing compound catabolic process
is_a: GO:0043171 ! peptide catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900803 ! brevianamide F metabolic process
created_by: di
creation_date: 2012-06-04T09:52:41Z

[Term]
id: GO:1900805
name: brevianamide F biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of brevianamide F." [GOC:di, GOC:TermGenie]
synonym: "brevianamide F anabolism" EXACT [GOC:TermGenie]
synonym: "brevianamide F biosynthesis" EXACT [GOC:TermGenie]
synonym: "brevianamide F formation" EXACT [GOC:TermGenie]
synonym: "brevianamide F synthesis" EXACT [GOC:TermGenie]
synonym: "C16H17N3O2 anabolism" RELATED [GOC:TermGenie]
synonym: "C16H17N3O2 biosynthesis" RELATED [GOC:TermGenie]
synonym: "C16H17N3O2 biosynthetic process" RELATED [GOC:TermGenie]
synonym: "C16H17N3O2 formation" RELATED [GOC:TermGenie]
synonym: "C16H17N3O2 synthesis" RELATED [GOC:TermGenie]
synonym: "cyclo-(Trp-Pro) anabolism" RELATED [GOC:TermGenie]
synonym: "cyclo-(Trp-Pro) biosynthesis" RELATED [GOC:TermGenie]
synonym: "cyclo-(Trp-Pro) biosynthetic process" RELATED [GOC:TermGenie]
synonym: "cyclo-(Trp-Pro) formation" RELATED [GOC:TermGenie]
synonym: "cyclo-(Trp-Pro) synthesis" RELATED [GOC:TermGenie]
synonym: "cyclo-L-Trp-L-Pro anabolism" RELATED [GOC:TermGenie]
synonym: "cyclo-L-Trp-L-Pro biosynthesis" RELATED [GOC:TermGenie]
synonym: "cyclo-L-Trp-L-Pro biosynthetic process" RELATED [GOC:TermGenie]
synonym: "cyclo-L-Trp-L-Pro formation" RELATED [GOC:TermGenie]
synonym: "cyclo-L-Trp-L-Pro synthesis" RELATED [GOC:TermGenie]
synonym: "cyclo-L-tryptophanyl-L-proline anabolism" RELATED [GOC:TermGenie]
synonym: "cyclo-L-tryptophanyl-L-proline biosynthesis" RELATED [GOC:TermGenie]
synonym: "cyclo-L-tryptophanyl-L-proline biosynthetic process" RELATED [GOC:TermGenie]
synonym: "cyclo-L-tryptophanyl-L-proline formation" RELATED [GOC:TermGenie]
synonym: "cyclo-L-tryptophanyl-L-proline synthesis" RELATED [GOC:TermGenie]
synonym: "L-prolyl-L-tryptophan anhydride anabolism" RELATED [GOC:TermGenie]
synonym: "L-prolyl-L-tryptophan anhydride biosynthesis" RELATED [GOC:TermGenie]
synonym: "L-prolyl-L-tryptophan anhydride biosynthetic process" RELATED [GOC:TermGenie]
synonym: "L-prolyl-L-tryptophan anhydride formation" RELATED [GOC:TermGenie]
synonym: "L-prolyl-L-tryptophan anhydride synthesis" RELATED [GOC:TermGenie]
synonym: "L-tryptophyl-L-proline cyclic anhydride anabolism" RELATED [GOC:TermGenie]
synonym: "L-tryptophyl-L-proline cyclic anhydride biosynthesis" RELATED [GOC:TermGenie]
synonym: "L-tryptophyl-L-proline cyclic anhydride biosynthetic process" RELATED [GOC:TermGenie]
synonym: "L-tryptophyl-L-proline cyclic anhydride formation" RELATED [GOC:TermGenie]
synonym: "L-tryptophyl-L-proline cyclic anhydride synthesis" RELATED [GOC:TermGenie]
synonym: "tryptophan-proline diketopiperazine anabolism" RELATED [GOC:TermGenie]
synonym: "tryptophan-proline diketopiperazine biosynthesis" RELATED [GOC:TermGenie]
synonym: "tryptophan-proline diketopiperazine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "tryptophan-proline diketopiperazine formation" RELATED [GOC:TermGenie]
synonym: "tryptophan-proline diketopiperazine synthesis" RELATED [GOC:TermGenie]
is_a: GO:0042435 ! indole-containing compound biosynthetic process
is_a: GO:0043043 ! peptide biosynthetic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:1900803 ! brevianamide F metabolic process
created_by: di
creation_date: 2012-06-04T09:52:48Z

[Term]
id: GO:1900806
name: ergot alkaloid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ergot alkaloid." [GOC:di, GOC:TermGenie]
synonym: "ergot alkaloid breakdown" EXACT [GOC:TermGenie]
synonym: "ergot alkaloid catabolism" EXACT [GOC:TermGenie]
synonym: "ergot alkaloid degradation" EXACT [GOC:TermGenie]
synonym: "ergot alkaloids breakdown" RELATED [GOC:TermGenie]
synonym: "ergot alkaloids catabolic process" RELATED [GOC:TermGenie]
synonym: "ergot alkaloids catabolism" RELATED [GOC:TermGenie]
synonym: "ergot alkaloids degradation" RELATED [GOC:TermGenie]
is_a: GO:0009822 ! alkaloid catabolic process
is_a: GO:0035836 ! ergot alkaloid metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0090487 ! secondary metabolite catabolic process
created_by: di
creation_date: 2012-06-04T09:57:39Z

[Term]
id: GO:1900807
name: fumigaclavine C metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fumigaclavine C." [GOC:di, GOC:TermGenie]
synonym: "fumigaclavine C metabolism" EXACT [GOC:TermGenie]
is_a: GO:0035836 ! ergot alkaloid metabolic process
is_a: GO:0097164 ! ammonium ion metabolic process
is_a: GO:1900619 ! acetate ester metabolic process
created_by: di
creation_date: 2012-06-04T09:59:32Z

[Term]
id: GO:1900808
name: fumigaclavine C catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of fumigaclavine C." [GOC:di, GOC:TermGenie]
synonym: "fumigaclavine C breakdown" EXACT [GOC:TermGenie]
synonym: "fumigaclavine C catabolism" EXACT [GOC:TermGenie]
synonym: "fumigaclavine C degradation" EXACT [GOC:TermGenie]
is_a: GO:1900806 ! ergot alkaloid catabolic process
is_a: GO:1900807 ! fumigaclavine C metabolic process
created_by: di
creation_date: 2012-06-04T09:59:55Z

[Term]
id: GO:1900809
name: fumigaclavine C biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of fumigaclavine C." [GOC:di, GOC:TermGenie]
synonym: "fumigaclavine C anabolism" EXACT [GOC:TermGenie]
synonym: "fumigaclavine C biosynthesis" EXACT [GOC:TermGenie]
synonym: "fumigaclavine C formation" EXACT [GOC:TermGenie]
synonym: "fumigaclavine C synthesis" EXACT [GOC:TermGenie]
is_a: GO:0035837 ! ergot alkaloid biosynthetic process
is_a: GO:1900620 ! acetate ester biosynthetic process
is_a: GO:1900807 ! fumigaclavine C metabolic process
created_by: di
creation_date: 2012-06-04T10:00:06Z

[Term]
id: GO:1900810
name: helvolic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving helvolic acid." [GOC:di, GOC:TermGenie]
synonym: "Fumigacin metabolic process" RELATED [GOC:TermGenie]
synonym: "Fumigacin metabolism" RELATED [GOC:TermGenie]
synonym: "helvolic acid metabolism" EXACT [GOC:TermGenie]
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042180 ! cellular ketone metabolic process
created_by: di
creation_date: 2012-06-04T10:02:28Z

[Term]
id: GO:1900811
name: helvolic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of helvolic acid." [GOC:di, GOC:TermGenie]
synonym: "Fumigacin breakdown" RELATED [GOC:TermGenie]
synonym: "Fumigacin catabolic process" RELATED [GOC:TermGenie]
synonym: "Fumigacin catabolism" RELATED [GOC:TermGenie]
synonym: "Fumigacin degradation" RELATED [GOC:TermGenie]
synonym: "helvolic acid breakdown" EXACT [GOC:TermGenie]
synonym: "helvolic acid catabolism" EXACT [GOC:TermGenie]
synonym: "helvolic acid degradation" EXACT [GOC:TermGenie]
is_a: GO:0006706 ! steroid catabolic process
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900810 ! helvolic acid metabolic process
created_by: di
creation_date: 2012-06-04T10:02:51Z

[Term]
id: GO:1900812
name: helvolic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of helvolic acid." [GOC:di, GOC:TermGenie]
synonym: "Fumigacin anabolism" RELATED [GOC:TermGenie]
synonym: "Fumigacin biosynthesis" RELATED [GOC:TermGenie]
synonym: "Fumigacin biosynthetic process" RELATED [GOC:TermGenie]
synonym: "Fumigacin formation" RELATED [GOC:TermGenie]
synonym: "Fumigacin synthesis" RELATED [GOC:TermGenie]
synonym: "helvolic acid anabolism" EXACT [GOC:TermGenie]
synonym: "helvolic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "helvolic acid formation" EXACT [GOC:TermGenie]
synonym: "helvolic acid synthesis" EXACT [GOC:TermGenie]
is_a: GO:0006694 ! steroid biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:1900810 ! helvolic acid metabolic process
created_by: di
creation_date: 2012-06-04T10:02:58Z

[Term]
id: GO:1900813
name: monodictyphenone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving monodictyphenone." [GOC:di, GOC:TermGenie]
synonym: "monodictyphenone metabolism" EXACT [GOC:TermGenie]
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042180 ! cellular ketone metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process
created_by: di
creation_date: 2012-06-04T10:11:03Z

[Term]
id: GO:1900814
name: monodictyphenone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of monodictyphenone." [GOC:di, GOC:TermGenie]
synonym: "monodictyphenone breakdown" EXACT [GOC:TermGenie]
synonym: "monodictyphenone catabolism" EXACT [GOC:TermGenie]
synonym: "monodictyphenone degradation" EXACT [GOC:TermGenie]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900813 ! monodictyphenone metabolic process
created_by: di
creation_date: 2012-06-04T10:11:27Z

[Term]
id: GO:1900815
name: monodictyphenone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of monodictyphenone." [GOC:di, GOC:TermGenie]
synonym: "monodictyphenone anabolism" EXACT [GOC:TermGenie]
synonym: "monodictyphenone biosynthesis" EXACT [GOC:TermGenie]
synonym: "monodictyphenone formation" EXACT [GOC:TermGenie]
synonym: "monodictyphenone synthesis" EXACT [GOC:TermGenie]
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:1900813 ! monodictyphenone metabolic process
created_by: di
creation_date: 2012-06-04T10:11:35Z

[Term]
id: GO:1900816
name: ochratoxin A metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ochratoxin A." [GOC:di, GOC:TermGenie]
synonym: "Ochratoxin A metabolic process" EXACT [GOC:TermGenie]
synonym: "Ochratoxin A metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006575 ! cellular modified amino acid metabolic process
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process
is_a: GO:0043603 ! cellular amide metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
created_by: di
creation_date: 2012-06-04T10:13:02Z

[Term]
id: GO:1900817
name: ochratoxin A catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ochratoxin A." [GOC:di, GOC:TermGenie]
synonym: "Ochratoxin A breakdown" EXACT [GOC:TermGenie]
synonym: "ochratoxin A breakdown" EXACT [GOC:TermGenie]
synonym: "Ochratoxin A catabolic process" EXACT [GOC:TermGenie]
synonym: "Ochratoxin A catabolism" EXACT [GOC:TermGenie]
synonym: "ochratoxin A catabolism" EXACT [GOC:TermGenie]
synonym: "Ochratoxin A degradation" EXACT [GOC:TermGenie]
synonym: "ochratoxin A degradation" EXACT [GOC:TermGenie]
is_a: GO:0042219 ! cellular modified amino acid catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900816 ! ochratoxin A metabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
created_by: di
creation_date: 2012-06-04T10:13:26Z

[Term]
id: GO:1900818
name: ochratoxin A biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ochratoxin A." [GOC:di, GOC:TermGenie]
synonym: "Ochratoxin A anabolism" EXACT [GOC:TermGenie]
synonym: "Ochratoxin A biosynthesis" EXACT [GOC:TermGenie]
synonym: "Ochratoxin A biosynthetic process" EXACT [GOC:TermGenie]
synonym: "Ochratoxin A formation" EXACT [GOC:TermGenie]
synonym: "Ochratoxin A synthesis" EXACT [GOC:TermGenie]
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0042398 ! cellular modified amino acid biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
is_a: GO:1900816 ! ochratoxin A metabolic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
created_by: di
creation_date: 2012-06-04T10:13:32Z

[Term]
id: GO:1900819
name: orlandin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving orlandin." [GOC:di, GOC:TermGenie]
synonym: "orlandin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
created_by: di
creation_date: 2012-06-04T10:14:55Z

[Term]
id: GO:1900820
name: orlandin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of orlandin." [GOC:di, GOC:TermGenie]
synonym: "orlandin breakdown" EXACT [GOC:TermGenie]
synonym: "orlandin catabolism" EXACT [GOC:TermGenie]
synonym: "orlandin degradation" EXACT [GOC:TermGenie]
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900819 ! orlandin metabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
created_by: di
creation_date: 2012-06-04T10:15:17Z

[Term]
id: GO:1900821
name: orlandin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of orlandin." [GOC:di, GOC:TermGenie]
synonym: "orlandin anabolism" EXACT [GOC:TermGenie]
synonym: "orlandin biosynthesis" EXACT [GOC:TermGenie]
synonym: "orlandin formation" EXACT [GOC:TermGenie]
synonym: "orlandin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:1900819 ! orlandin metabolic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
created_by: di
creation_date: 2012-06-04T10:15:24Z

[Term]
id: GO:1900822
name: regulation of ergot alkaloid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ergot alkaloid biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of ergot alkaloid anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of ergot alkaloid biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of ergot alkaloid formation" EXACT [GOC:TermGenie]
synonym: "regulation of ergot alkaloid synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035837 ! ergot alkaloid biosynthetic process
relationship: regulates GO:0035837 ! ergot alkaloid biosynthetic process
created_by: di
creation_date: 2012-06-04T11:12:32Z

[Term]
id: GO:1900823
name: negative regulation of ergot alkaloid biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ergot alkaloid biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of ergot alkaloid anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of ergot alkaloid biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of ergot alkaloid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of ergot alkaloid formation" EXACT [GOC:TermGenie]
synonym: "down regulation of ergot alkaloid synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of ergot alkaloid anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of ergot alkaloid biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of ergot alkaloid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of ergot alkaloid formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of ergot alkaloid synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of ergot alkaloid anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of ergot alkaloid biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of ergot alkaloid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of ergot alkaloid formation" EXACT [GOC:TermGenie]
synonym: "downregulation of ergot alkaloid synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of ergot alkaloid anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of ergot alkaloid biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of ergot alkaloid biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of ergot alkaloid formation" EXACT [GOC:TermGenie]
synonym: "inhibition of ergot alkaloid synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of ergot alkaloid anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of ergot alkaloid biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of ergot alkaloid formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of ergot alkaloid synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900822 ! regulation of ergot alkaloid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035837 ! ergot alkaloid biosynthetic process
relationship: negatively_regulates GO:0035837 ! ergot alkaloid biosynthetic process
created_by: di
creation_date: 2012-06-04T11:12:54Z

[Term]
id: GO:1900824
name: positive regulation of ergot alkaloid biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ergot alkaloid biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of ergot alkaloid anabolism" EXACT [GOC:TermGenie]
synonym: "activation of ergot alkaloid biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of ergot alkaloid biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of ergot alkaloid formation" EXACT [GOC:TermGenie]
synonym: "activation of ergot alkaloid synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of ergot alkaloid anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of ergot alkaloid biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of ergot alkaloid formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of ergot alkaloid synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of ergot alkaloid anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of ergot alkaloid biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of ergot alkaloid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of ergot alkaloid formation" EXACT [GOC:TermGenie]
synonym: "up regulation of ergot alkaloid synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of ergot alkaloid anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of ergot alkaloid biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of ergot alkaloid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of ergot alkaloid formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of ergot alkaloid synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of ergot alkaloid anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of ergot alkaloid biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of ergot alkaloid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of ergot alkaloid formation" EXACT [GOC:TermGenie]
synonym: "upregulation of ergot alkaloid synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900822 ! regulation of ergot alkaloid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035837 ! ergot alkaloid biosynthetic process
relationship: positively_regulates GO:0035837 ! ergot alkaloid biosynthetic process
created_by: di
creation_date: 2012-06-04T11:13:05Z

[Term]
id: GO:1900825
name: regulation of membrane depolarization during cardiac muscle cell action potential
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of membrane depolarization during a cardiac muscle cell action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:TermGenie]
is_a: GO:0098901 ! regulation of cardiac muscle cell action potential
is_a: GO:0098902 ! regulation of membrane depolarization during action potential
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: regulates GO:0086012 ! membrane depolarization during cardiac muscle cell action potential
relationship: regulates GO:0086012 ! membrane depolarization during cardiac muscle cell action potential
created_by: rl
creation_date: 2012-06-06T04:15:20Z

[Term]
id: GO:1900826
name: negative regulation of membrane depolarization during cardiac muscle cell action potential
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of membrane depolarization during a cardiac muscle cell action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:TermGenie]
synonym: "down regulation of membrane depolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "down-regulation of membrane depolarization during of cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "downregulation of membrane depolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "inhibition of membrane depolarization during cardiac muscle cell action potential" NARROW [GOC:TermGenie]
is_a: GO:0045759 ! negative regulation of action potential
is_a: GO:1900825 ! regulation of membrane depolarization during cardiac muscle cell action potential
is_a: GO:1904180 ! negative regulation of membrane depolarization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0086012 ! membrane depolarization during cardiac muscle cell action potential
relationship: negatively_regulates GO:0086012 ! membrane depolarization during cardiac muscle cell action potential
created_by: rl
creation_date: 2012-06-06T04:15:40Z

[Term]
id: GO:1900827
name: positive regulation of membrane depolarization during cardiac muscle cell action potential
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of membrane depolarization during a cardiac muscle cell action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:TermGenie]
synonym: "activation of membrane depolarization during cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "up regulation of membrane depolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up-regulation of membrane depolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "upregulation of membrane depolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie]
is_a: GO:0045760 ! positive regulation of action potential
is_a: GO:1900825 ! regulation of membrane depolarization during cardiac muscle cell action potential
is_a: GO:1904181 ! positive regulation of membrane depolarization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0086012 ! membrane depolarization during cardiac muscle cell action potential
relationship: positively_regulates GO:0086012 ! membrane depolarization during cardiac muscle cell action potential
created_by: rl
creation_date: 2012-06-06T04:15:48Z

[Term]
id: GO:1900828
name: D-tyrosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-tyrosine." [GOC:TermGenie, PMID:10766779]
synonym: "D-tyrosine metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006570 ! tyrosine metabolic process
is_a: GO:0046416 ! D-amino acid metabolic process
created_by: se
creation_date: 2012-06-06T09:27:00Z

[Term]
id: GO:1900829
name: D-tyrosine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-tyrosine." [GOC:TermGenie, PMID:10766779]
synonym: "D-tyrosine breakdown" EXACT [GOC:TermGenie]
synonym: "D-tyrosine catabolism" EXACT [GOC:TermGenie]
synonym: "D-tyrosine degradation" EXACT [GOC:TermGenie]
is_a: GO:0006572 ! tyrosine catabolic process
is_a: GO:0019478 ! D-amino acid catabolic process
is_a: GO:1900828 ! D-tyrosine metabolic process
created_by: se
creation_date: 2012-06-06T09:27:24Z

[Term]
id: GO:1900830
name: D-tyrosine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of D-tyrosine." [GOC:TermGenie, PMID:10766779]
synonym: "D-tyrosine anabolism" EXACT [GOC:TermGenie]
synonym: "D-tyrosine biosynthesis" EXACT [GOC:TermGenie]
synonym: "D-tyrosine formation" EXACT [GOC:TermGenie]
synonym: "D-tyrosine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0006571 ! tyrosine biosynthetic process
is_a: GO:0046437 ! D-amino acid biosynthetic process
is_a: GO:1900828 ! D-tyrosine metabolic process
created_by: se
creation_date: 2012-06-06T09:27:31Z

[Term]
id: GO:1900831
name: D-leucine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-leucine." [GOC:TermGenie, PMID:10918062]
synonym: "D-leucine metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006551 ! leucine metabolic process
is_a: GO:0046416 ! D-amino acid metabolic process
created_by: se
creation_date: 2012-06-06T09:37:17Z

[Term]
id: GO:1900832
name: D-leucine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-leucine." [GOC:TermGenie, PMID:10918062]
synonym: "D-leucine breakdown" EXACT [GOC:TermGenie]
synonym: "D-leucine catabolism" EXACT [GOC:TermGenie]
synonym: "D-leucine degradation" EXACT [GOC:TermGenie]
is_a: GO:0006552 ! leucine catabolic process
is_a: GO:0019478 ! D-amino acid catabolic process
is_a: GO:1900831 ! D-leucine metabolic process
created_by: se
creation_date: 2012-06-06T09:37:40Z

[Term]
id: GO:1900833
name: D-leucine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of D-leucine." [GOC:TermGenie, PMID:10918062]
synonym: "D-leucine anabolism" EXACT [GOC:TermGenie]
synonym: "D-leucine biosynthesis" EXACT [GOC:TermGenie]
synonym: "D-leucine formation" EXACT [GOC:TermGenie]
synonym: "D-leucine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009098 ! leucine biosynthetic process
is_a: GO:0046437 ! D-amino acid biosynthetic process
is_a: GO:1900831 ! D-leucine metabolic process
created_by: se
creation_date: 2012-06-06T09:37:47Z

[Term]
id: GO:1900834
name: regulation of emericellin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of emericellin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of emericellin anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of emericellin biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of emericellin formation" EXACT [GOC:TermGenie]
synonym: "regulation of emericellin synthesis" EXACT [GOC:TermGenie]
synonym: "regulation of Variecoxanthone B anabolism" RELATED [GOC:TermGenie]
synonym: "regulation of Variecoxanthone B biosynthesis" RELATED [GOC:TermGenie]
synonym: "regulation of Variecoxanthone B biosynthetic process" RELATED [GOC:TermGenie]
synonym: "regulation of Variecoxanthone B formation" RELATED [GOC:TermGenie]
synonym: "regulation of Variecoxanthone B synthesis" RELATED [GOC:TermGenie]
is_a: GO:1900183 ! regulation of xanthone-containing compound biosynthetic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900766 ! emericellin biosynthetic process
relationship: regulates GO:1900766 ! emericellin biosynthetic process
created_by: di
creation_date: 2012-06-07T09:32:02Z

[Term]
id: GO:1900835
name: negative regulation of emericellin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of emericellin biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of emericellin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of emericellin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of emericellin biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:1900184 ! negative regulation of xanthone-containing compound biosynthetic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900834 ! regulation of emericellin biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900766 ! emericellin biosynthetic process
relationship: negatively_regulates GO:1900766 ! emericellin biosynthetic process
created_by: di
creation_date: 2012-06-07T09:32:24Z

[Term]
id: GO:1900836
name: positive regulation of emericellin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of emericellin biosynthetic process." [GOC:di, GOC:TermGenie]
is_a: GO:1900185 ! positive regulation of xanthone-containing compound biosynthetic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900834 ! regulation of emericellin biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900766 ! emericellin biosynthetic process
relationship: positively_regulates GO:1900766 ! emericellin biosynthetic process
created_by: di
creation_date: 2012-06-07T09:32:31Z

[Term]
id: GO:1900837
name: regulation of fumigaclavine C biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fumigaclavine C biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of fumigaclavine C anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of fumigaclavine C biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of fumigaclavine C formation" EXACT [GOC:TermGenie]
synonym: "regulation of fumigaclavine C synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900822 ! regulation of ergot alkaloid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900809 ! fumigaclavine C biosynthetic process
relationship: regulates GO:1900809 ! fumigaclavine C biosynthetic process
created_by: di
creation_date: 2012-06-07T09:36:22Z

[Term]
id: GO:1900838
name: negative regulation of fumigaclavine C biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of fumigaclavine C biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "inhibition of fumigaclavine C biosynthetic process" NARROW [GOC:TermGenie]
is_a: GO:1900823 ! negative regulation of ergot alkaloid biosynthetic process
is_a: GO:1900837 ! regulation of fumigaclavine C biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900809 ! fumigaclavine C biosynthetic process
relationship: negatively_regulates GO:1900809 ! fumigaclavine C biosynthetic process
created_by: di
creation_date: 2012-06-07T09:36:45Z

[Term]
id: GO:1900839
name: positive regulation of fumigaclavine C biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of fumigaclavine C biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "up regulation of fumigaclavine C biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of fumigaclavine C biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of fumigaclavine C biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:1900824 ! positive regulation of ergot alkaloid biosynthetic process
is_a: GO:1900837 ! regulation of fumigaclavine C biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900809 ! fumigaclavine C biosynthetic process
relationship: positively_regulates GO:1900809 ! fumigaclavine C biosynthetic process
created_by: di
creation_date: 2012-06-07T09:36:52Z

[Term]
id: GO:1900840
name: regulation of helvolic acid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of helvolic acid biosynthetic process." [GOC:di, GOC:TermGenie]
is_a: GO:0010566 ! regulation of ketone biosynthetic process
is_a: GO:0050810 ! regulation of steroid biosynthetic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900812 ! helvolic acid biosynthetic process
relationship: regulates GO:1900812 ! helvolic acid biosynthetic process
created_by: di
creation_date: 2012-06-07T09:38:33Z

[Term]
id: GO:1900841
name: negative regulation of helvolic acid biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of helvolic acid biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of helvolic acid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of helvolic acid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of helvolic acid biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0010894 ! negative regulation of steroid biosynthetic process
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900840 ! regulation of helvolic acid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900812 ! helvolic acid biosynthetic process
relationship: negatively_regulates GO:1900812 ! helvolic acid biosynthetic process
created_by: di
creation_date: 2012-06-07T09:38:57Z

[Term]
id: GO:1900842
name: positive regulation of helvolic acid biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of helvolic acid biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "up regulation of helvolic acid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of helvolic acid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of helvolic acid biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0010893 ! positive regulation of steroid biosynthetic process
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900840 ! regulation of helvolic acid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900812 ! helvolic acid biosynthetic process
relationship: positively_regulates GO:1900812 ! helvolic acid biosynthetic process
created_by: di
creation_date: 2012-06-07T09:39:05Z

[Term]
id: GO:1900843
name: regulation of monodictyphenone biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of monodictyphenone biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of monodictyphenone anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of monodictyphenone biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of monodictyphenone formation" EXACT [GOC:TermGenie]
synonym: "regulation of monodictyphenone synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010566 ! regulation of ketone biosynthetic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900815 ! monodictyphenone biosynthetic process
relationship: regulates GO:1900815 ! monodictyphenone biosynthetic process
created_by: di
creation_date: 2012-06-07T09:40:38Z

[Term]
id: GO:1900844
name: negative regulation of monodictyphenone biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of monodictyphenone biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of monodictyphenone biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of monodictyphenone biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of monodictyphenone biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900843 ! regulation of monodictyphenone biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900815 ! monodictyphenone biosynthetic process
relationship: negatively_regulates GO:1900815 ! monodictyphenone biosynthetic process
created_by: di
creation_date: 2012-06-07T09:41:00Z

[Term]
id: GO:1900845
name: positive regulation of monodictyphenone biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of monodictyphenone biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "upregulation of monodictyphenone biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900843 ! regulation of monodictyphenone biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900815 ! monodictyphenone biosynthetic process
relationship: positively_regulates GO:1900815 ! monodictyphenone biosynthetic process
created_by: di
creation_date: 2012-06-07T09:41:08Z

[Term]
id: GO:1900846
name: regulation of naphtho-gamma-pyrone biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of naphtho-gamma-pyrone biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of naphtho-gamma-pyrone anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of naphtho-gamma-pyrone biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of naphtho-gamma-pyrone formation" EXACT [GOC:TermGenie]
synonym: "regulation of naphtho-gamma-pyrone synthesis" EXACT [GOC:TermGenie]
synonym: "regulation of naphtho-gamma-pyrones anabolism" RELATED [GOC:TermGenie]
synonym: "regulation of naphtho-gamma-pyrones biosynthesis" RELATED [GOC:TermGenie]
synonym: "regulation of naphtho-gamma-pyrones biosynthetic process" RELATED [GOC:TermGenie]
synonym: "regulation of naphtho-gamma-pyrones formation" RELATED [GOC:TermGenie]
synonym: "regulation of naphtho-gamma-pyrones synthesis" RELATED [GOC:TermGenie]
is_a: GO:0010566 ! regulation of ketone biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900787 ! naphtho-gamma-pyrone biosynthetic process
relationship: regulates GO:1900787 ! naphtho-gamma-pyrone biosynthetic process
created_by: di
creation_date: 2012-06-07T09:42:41Z

[Term]
id: GO:1900847
name: negative regulation of naphtho-gamma-pyrone biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of naphtho-gamma-pyrone biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of naphtho-gamma-pyrone biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of naphtho-gamma-pyrone biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of naphtho-gamma-pyrone biosynthetic process" EXACT [GOC:TermGenie]
synonym: "inhibition of naphtho-gamma-pyrone biosynthetic process" NARROW [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:1900846 ! regulation of naphtho-gamma-pyrone biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900787 ! naphtho-gamma-pyrone biosynthetic process
relationship: negatively_regulates GO:1900787 ! naphtho-gamma-pyrone biosynthetic process
created_by: di
creation_date: 2012-06-07T09:43:03Z

[Term]
id: GO:1900848
name: positive regulation of naphtho-gamma-pyrone biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of naphtho-gamma-pyrone biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of naphtho-gamma-pyrone biosynthetic process" NARROW [GOC:TermGenie]
synonym: "up regulation of naphtho-gamma-pyrone biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of naphtho-gamma-pyrone biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of naphtho-gamma-pyrone biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:1900846 ! regulation of naphtho-gamma-pyrone biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900787 ! naphtho-gamma-pyrone biosynthetic process
relationship: positively_regulates GO:1900787 ! naphtho-gamma-pyrone biosynthetic process
created_by: di
creation_date: 2012-06-07T09:43:11Z

[Term]
id: GO:1900849
name: regulation of pseurotin A biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pseurotin A biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of pseurotin A anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of pseurotin A biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of pseurotin A formation" EXACT [GOC:TermGenie]
synonym: "regulation of pseurotin A synthesis" EXACT [GOC:TermGenie]
synonym: "regulation of Pseurotin anabolism" RELATED [GOC:TermGenie]
synonym: "regulation of Pseurotin biosynthesis" RELATED [GOC:TermGenie]
synonym: "regulation of Pseurotin biosynthetic process" RELATED [GOC:TermGenie]
synonym: "regulation of Pseurotin formation" RELATED [GOC:TermGenie]
synonym: "regulation of Pseurotin synthesis" RELATED [GOC:TermGenie]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0034248 ! regulation of cellular amide metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900790 ! pseurotin A biosynthetic process
relationship: regulates GO:1900790 ! pseurotin A biosynthetic process
created_by: di
creation_date: 2012-06-07T09:45:27Z

[Term]
id: GO:1900850
name: negative regulation of pseurotin A biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of pseurotin A biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of pseurotin A biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of pseurotin A biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of pseurotin A biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0034249 ! negative regulation of cellular amide metabolic process
is_a: GO:1900849 ! regulation of pseurotin A biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900790 ! pseurotin A biosynthetic process
relationship: negatively_regulates GO:1900790 ! pseurotin A biosynthetic process
created_by: di
creation_date: 2012-06-07T09:45:49Z

[Term]
id: GO:1900851
name: positive regulation of pseurotin A biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pseurotin A biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "up regulation of pseurotin A biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of pseurotin A biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of pseurotin A biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0034250 ! positive regulation of cellular amide metabolic process
is_a: GO:1900849 ! regulation of pseurotin A biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900790 ! pseurotin A biosynthetic process
relationship: positively_regulates GO:1900790 ! pseurotin A biosynthetic process
created_by: di
creation_date: 2012-06-07T09:45:56Z

[Term]
id: GO:1900852
name: regulation of terrequinone A biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of terrequinone A biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of terrequinone A anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of terrequinone A biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of terrequinone A formation" EXACT [GOC:TermGenie]
synonym: "regulation of terrequinone A synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010566 ! regulation of ketone biosynthetic process
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
is_a: GO:0051196 ! regulation of coenzyme metabolic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900796 ! terrequinone A biosynthetic process
relationship: regulates GO:1900796 ! terrequinone A biosynthetic process
created_by: di
creation_date: 2012-06-07T09:47:09Z

[Term]
id: GO:1900853
name: negative regulation of terrequinone A biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of terrequinone A biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of terrequinone A biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of terrequinone A biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of terrequinone A biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process
is_a: GO:0051198 ! negative regulation of coenzyme metabolic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900852 ! regulation of terrequinone A biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900796 ! terrequinone A biosynthetic process
relationship: negatively_regulates GO:1900796 ! terrequinone A biosynthetic process
created_by: di
creation_date: 2012-06-07T09:47:30Z

[Term]
id: GO:1900854
name: positive regulation of terrequinone A biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of terrequinone A biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "up regulation of terrequinone A biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of terrequinone A biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of terrequinone A biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process
is_a: GO:0051197 ! positive regulation of coenzyme metabolic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900852 ! regulation of terrequinone A biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900796 ! terrequinone A biosynthetic process
relationship: positively_regulates GO:1900796 ! terrequinone A biosynthetic process
created_by: di
creation_date: 2012-06-07T09:47:38Z

[Term]
id: GO:1900855
name: regulation of fumitremorgin B biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fumitremorgin B biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of fumitremorgin B anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of fumitremorgin B biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of fumitremorgin B formation" EXACT [GOC:TermGenie]
synonym: "regulation of fumitremorgin B synthesis" EXACT [GOC:TermGenie]
synonym: "regulation of Lanosulin anabolism" RELATED [GOC:TermGenie]
synonym: "regulation of Lanosulin biosynthesis" RELATED [GOC:TermGenie]
synonym: "regulation of Lanosulin biosynthetic process" RELATED [GOC:TermGenie]
synonym: "regulation of Lanosulin formation" RELATED [GOC:TermGenie]
synonym: "regulation of Lanosulin synthesis" RELATED [GOC:TermGenie]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900772 ! fumitremorgin B biosynthetic process
relationship: regulates GO:1900772 ! fumitremorgin B biosynthetic process
created_by: di
creation_date: 2012-06-07T09:50:37Z

[Term]
id: GO:1900856
name: negative regulation of fumitremorgin B biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of fumitremorgin B biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of fumitremorgin B biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of fumitremorgin B biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of fumitremorgin B biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900855 ! regulation of fumitremorgin B biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900772 ! fumitremorgin B biosynthetic process
relationship: negatively_regulates GO:1900772 ! fumitremorgin B biosynthetic process
created_by: di
creation_date: 2012-06-07T09:51:01Z

[Term]
id: GO:1900857
name: positive regulation of fumitremorgin B biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of fumitremorgin B biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "up regulation of fumitremorgin B biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of fumitremorgin B biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of fumitremorgin B biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900855 ! regulation of fumitremorgin B biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900772 ! fumitremorgin B biosynthetic process
relationship: positively_regulates GO:1900772 ! fumitremorgin B biosynthetic process
created_by: di
creation_date: 2012-06-07T09:51:09Z

[Term]
id: GO:1900858
name: regulation of brevianamide F biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of brevianamide F biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of brevianamide F anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of brevianamide F biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of brevianamide F formation" EXACT [GOC:TermGenie]
synonym: "regulation of brevianamide F synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0034248 ! regulation of cellular amide metabolic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900805 ! brevianamide F biosynthetic process
relationship: regulates GO:1900805 ! brevianamide F biosynthetic process
created_by: di
creation_date: 2012-06-07T09:52:56Z

[Term]
id: GO:1900859
name: negative regulation of brevianamide F biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of brevianamide F biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of brevianamide F biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of brevianamide F biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of brevianamide F biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0034249 ! negative regulation of cellular amide metabolic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900858 ! regulation of brevianamide F biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900805 ! brevianamide F biosynthetic process
relationship: negatively_regulates GO:1900805 ! brevianamide F biosynthetic process
created_by: di
creation_date: 2012-06-07T09:53:17Z

[Term]
id: GO:1900860
name: positive regulation of brevianamide F biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of brevianamide F biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "up regulation of brevianamide F biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of brevianamide F biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of brevianamide F biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0034250 ! positive regulation of cellular amide metabolic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900858 ! regulation of brevianamide F biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900805 ! brevianamide F biosynthetic process
relationship: positively_regulates GO:1900805 ! brevianamide F biosynthetic process
created_by: di
creation_date: 2012-06-07T09:53:25Z

[Term]
id: GO:1900861
name: regulation of cordyol C biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cordyol C biosynthetic process." [GOC:di, GOC:TermGenie]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900799 ! cordyol C biosynthetic process
relationship: regulates GO:1900799 ! cordyol C biosynthetic process
created_by: di
creation_date: 2012-06-07T01:56:16Z

[Term]
id: GO:1900862
name: negative regulation of cordyol C biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cordyol C biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of cordyol C biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of cordyol C biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of cordyol C biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900861 ! regulation of cordyol C biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900799 ! cordyol C biosynthetic process
relationship: negatively_regulates GO:1900799 ! cordyol C biosynthetic process
created_by: di
creation_date: 2012-06-07T01:56:38Z

[Term]
id: GO:1900863
name: positive regulation of cordyol C biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cordyol C biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of cordyol C biosynthetic process" NARROW [GOC:TermGenie]
synonym: "up regulation of cordyol C biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of cordyol C biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of cordyol C biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900861 ! regulation of cordyol C biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900799 ! cordyol C biosynthetic process
relationship: positively_regulates GO:1900799 ! cordyol C biosynthetic process
created_by: di
creation_date: 2012-06-07T01:56:46Z

[Term]
id: GO:1900864
name: mitochondrial RNA modification
namespace: biological_process
def: "Any RNA modification that takes place in mitochondrion." [GOC:TermGenie]
synonym: "mitochondrial RNA editing" NARROW [GOC:TermGenie]
is_a: GO:0000959 ! mitochondrial RNA metabolic process
is_a: GO:0009451 ! RNA modification
intersection_of: GO:0009451 ! RNA modification
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion
created_by: tb
creation_date: 2012-06-11T10:49:56Z

[Term]
id: GO:1900865
name: chloroplast RNA modification
namespace: biological_process
def: "Any RNA modification that takes place in chloroplast." [GOC:TermGenie]
synonym: "RNA editing in chloroplast" NARROW [GOC:TermGenie]
is_a: GO:0009451 ! RNA modification
intersection_of: GO:0009451 ! RNA modification
intersection_of: occurs_in GO:0009507 ! chloroplast
relationship: occurs_in GO:0009507 ! chloroplast
created_by: tb
creation_date: 2012-06-11T10:58:04Z

[Term]
id: GO:1900866
name: glycolate transport
namespace: biological_process
def: "The directed movement of a glycolate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:pr, GOC:TermGenie]
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0015850 ! organic hydroxy compound transport
created_by: pr
creation_date: 2012-06-12T04:29:56Z

[Term]
id: GO:1900867
name: sarcinapterin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sarcinapterin." [GOC:mengo_curators, GOC:TermGenie]
synonym: "sarcinapterin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0072350 ! tricarboxylic acid metabolic process
is_a: GO:2001115 ! methanopterin-containing compound metabolic process
created_by: tt
creation_date: 2012-06-12T04:34:10Z

[Term]
id: GO:1900868
name: sarcinapterin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sarcinapterin." [GOC:mengo_curators, GOC:TermGenie]
synonym: "sarcinapterin anabolism" EXACT [GOC:TermGenie]
synonym: "sarcinapterin biosynthesis" EXACT [GOC:TermGenie]
synonym: "sarcinapterin formation" EXACT [GOC:TermGenie]
synonym: "sarcinapterin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0072351 ! tricarboxylic acid biosynthetic process
is_a: GO:1900867 ! sarcinapterin metabolic process
is_a: GO:2001116 ! methanopterin-containing compound biosynthetic process
created_by: tt
creation_date: 2012-06-12T04:34:33Z

[Term]
id: GO:1900869
name: tatiopterin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tatiopterin." [GOC:mengo_curators, GOC:TermGenie]
synonym: "tatiopterin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006793 ! phosphorus metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process
is_a: GO:0042558 ! pteridine-containing compound metabolic process
created_by: tt
creation_date: 2012-06-12T04:43:57Z

[Term]
id: GO:1900870
name: tatiopterin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tatiopterin." [GOC:mengo_curators, GOC:TermGenie]
synonym: "tatiopterin anabolism" EXACT [GOC:TermGenie]
synonym: "tatiopterin biosynthesis" EXACT [GOC:TermGenie]
synonym: "tatiopterin formation" EXACT [GOC:TermGenie]
synonym: "tatiopterin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0042559 ! pteridine-containing compound biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
is_a: GO:1900869 ! tatiopterin metabolic process
created_by: tt
creation_date: 2012-06-12T04:44:19Z

[Term]
id: GO:1900871
name: chloroplast mRNA modification
namespace: biological_process
def: "The covalent alteration within the chloroplast of one or more nucleotides within an mRNA to produce an mRNA molecule with a sequence that differs from that coded genetically." [GOC:TermGenie, PMID:1653905]
synonym: "chloroplast mRNA editing" NARROW []
synonym: "mRNA editing in chloroplast" NARROW [GOC:TermGenie]
is_a: GO:0016556 ! mRNA modification
is_a: GO:1900865 ! chloroplast RNA modification
intersection_of: GO:0016556 ! mRNA modification
intersection_of: occurs_in GO:0009507 ! chloroplast
relationship: occurs_in GO:0009507 ! chloroplast
created_by: dhl
creation_date: 2012-06-12T06:13:58Z

[Term]
id: GO:1900872
name: pentadec-1-ene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pentadec-1-ene." [GOC:mengo_curators, GOC:TermGenie]
synonym: "pentadec-1-ene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0043449 ! cellular alkene metabolic process
created_by: tt
creation_date: 2012-06-13T01:45:22Z

[Term]
id: GO:1900873
name: pentadec-1-ene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pentadec-1-ene." [GOC:mengo_curators, GOC:TermGenie]
synonym: "pentadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "pentadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "pentadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "pentadec-1-ene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0043450 ! alkene biosynthetic process
is_a: GO:1900872 ! pentadec-1-ene metabolic process
created_by: tt
creation_date: 2012-06-13T01:45:45Z

[Term]
id: GO:1900874
name: heptadec-1-ene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving heptadec-1-ene." [GOC:mengo_curators, GOC:TermGenie]
synonym: "heptadec-1-ene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0043449 ! cellular alkene metabolic process
created_by: tt
creation_date: 2012-06-13T01:49:51Z

[Term]
id: GO:1900875
name: heptadec-1-ene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of heptadec-1-ene." [GOC:mengo_curators, GOC:TermGenie]
synonym: "heptadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "heptadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "heptadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "heptadec-1-ene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0043450 ! alkene biosynthetic process
is_a: GO:1900874 ! heptadec-1-ene metabolic process
created_by: tt
creation_date: 2012-06-13T01:50:11Z

[Term]
id: GO:1900876
name: nonadec-1-ene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nonadec-1-ene." [GOC:mengo_curators, GOC:TermGenie]
synonym: "nonadec-1-ene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0043449 ! cellular alkene metabolic process
created_by: tt
creation_date: 2012-06-13T01:52:09Z

[Term]
id: GO:1900877
name: nonadec-1-ene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nonadec-1-ene." [GOC:mengo_curators, GOC:TermGenie]
synonym: "nonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "nonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "nonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "nonadec-1-ene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0043450 ! alkene biosynthetic process
is_a: GO:1900876 ! nonadec-1-ene metabolic process
created_by: tt
creation_date: 2012-06-13T01:52:37Z

[Term]
id: GO:1900878
name: (Z)-nonadeca-1,14-diene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (Z)-nonadeca-1,14-diene." [GOC:mengo_curators, GOC:TermGenie]
synonym: "(Z)-nonadeca-1,14-diene metabolism" EXACT [GOC:TermGenie]
is_a: GO:1900673 ! olefin metabolic process
created_by: tt
creation_date: 2012-06-13T02:09:18Z

[Term]
id: GO:1900879
name: (Z)-nonadeca-1,14-diene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (Z)-nonadeca-1,14-diene." [GOC:mengo_curators, GOC:TermGenie]
synonym: "(Z)-nonadeca-1,14-diene anabolism" EXACT [GOC:TermGenie]
synonym: "(Z)-nonadeca-1,14-diene biosynthesis" EXACT [GOC:TermGenie]
synonym: "(Z)-nonadeca-1,14-diene formation" EXACT [GOC:TermGenie]
synonym: "(Z)-nonadeca-1,14-diene synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900674 ! olefin biosynthetic process
is_a: GO:1900878 ! (Z)-nonadeca-1,14-diene metabolic process
created_by: tt
creation_date: 2012-06-13T02:09:39Z

[Term]
id: GO:1900880
name: 18-methylnonadec-1-ene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 18-methylnonadec-1-ene." [GOC:mengo_curators, GOC:TermGenie]
synonym: "18-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0043449 ! cellular alkene metabolic process
created_by: tt
creation_date: 2012-06-13T02:26:28Z

[Term]
id: GO:1900881
name: 18-methylnonadec-1-ene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 18-methylnonadec-1-ene." [GOC:mengo_curators, GOC:TermGenie]
synonym: "18-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "18-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "18-methylnonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "18-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0043450 ! alkene biosynthetic process
is_a: GO:1900880 ! 18-methylnonadec-1-ene metabolic process
created_by: tt
creation_date: 2012-06-13T02:26:55Z

[Term]
id: GO:1900882
name: 17-methylnonadec-1-ene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 17-methylnonadec-1-ene." [GOC:mengo_curators, GOC:TermGenie]
synonym: "17-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0043449 ! cellular alkene metabolic process
created_by: tt
creation_date: 2012-06-13T02:35:37Z

[Term]
id: GO:1900883
name: 17-methylnonadec-1-ene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 17-methylnonadec-1-ene." [GOC:mengo_curators, GOC:TermGenie]
synonym: "17-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "17-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "17-methylnonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "17-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0043450 ! alkene biosynthetic process
is_a: GO:1900882 ! 17-methylnonadec-1-ene metabolic process
created_by: tt
creation_date: 2012-06-13T02:35:59Z

[Term]
id: GO:1900884
name: regulation of tridecane biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tridecane biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of tridecane anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of tridecane biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of tridecane formation" EXACT [GOC:TermGenie]
synonym: "regulation of tridecane synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900893 ! regulation of tridecane metabolic process
is_a: GO:1901577 ! regulation of alkane biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900632 ! tridecane biosynthetic process
relationship: regulates GO:1900632 ! tridecane biosynthetic process
created_by: tt
creation_date: 2012-06-13T03:00:31Z

[Term]
id: GO:1900885
name: negative regulation of tridecane biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tridecane biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of tridecane anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of tridecane biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of tridecane biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of tridecane formation" EXACT [GOC:TermGenie]
synonym: "down regulation of tridecane synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of tridecane anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of tridecane biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of tridecane biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of tridecane formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of tridecane synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of tridecane anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of tridecane biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of tridecane biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of tridecane formation" EXACT [GOC:TermGenie]
synonym: "downregulation of tridecane synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of tridecane anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of tridecane biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of tridecane biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of tridecane formation" NARROW [GOC:TermGenie]
synonym: "inhibition of tridecane synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of tridecane anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of tridecane biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of tridecane formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of tridecane synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900884 ! regulation of tridecane biosynthetic process
is_a: GO:1900894 ! negative regulation of tridecane metabolic process
is_a: GO:1901578 ! negative regulation of alkane biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900632 ! tridecane biosynthetic process
relationship: negatively_regulates GO:1900632 ! tridecane biosynthetic process
created_by: tt
creation_date: 2012-06-13T03:00:53Z

[Term]
id: GO:1900886
name: positive regulation of tridecane biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tridecane biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of tridecane anabolism" NARROW [GOC:TermGenie]
synonym: "activation of tridecane biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of tridecane biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of tridecane formation" NARROW [GOC:TermGenie]
synonym: "activation of tridecane synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of tridecane anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of tridecane biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of tridecane formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of tridecane synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of tridecane anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of tridecane biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of tridecane biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of tridecane formation" EXACT [GOC:TermGenie]
synonym: "up regulation of tridecane synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of tridecane anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of tridecane biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of tridecane biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of tridecane formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of tridecane synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of tridecane anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of tridecane biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of tridecane biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of tridecane formation" EXACT [GOC:TermGenie]
synonym: "upregulation of tridecane synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900884 ! regulation of tridecane biosynthetic process
is_a: GO:1900895 ! positive regulation of tridecane metabolic process
is_a: GO:1901579 ! positive regulation of alkane biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900632 ! tridecane biosynthetic process
relationship: positively_regulates GO:1900632 ! tridecane biosynthetic process
created_by: tt
creation_date: 2012-06-13T03:01:01Z

[Term]
id: GO:1900887
name: regulation of pentadecane biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pentadecane biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of pentadecane anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of pentadecane biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of pentadecane formation" EXACT [GOC:TermGenie]
synonym: "regulation of pentadecane synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900890 ! regulation of pentadecane metabolic process
is_a: GO:1901577 ! regulation of alkane biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900634 ! pentadecane biosynthetic process
relationship: regulates GO:1900634 ! pentadecane biosynthetic process
created_by: tt
creation_date: 2012-06-13T03:03:32Z

[Term]
id: GO:1900888
name: negative regulation of pentadecane biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of pentadecane biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of pentadecane anabolism" RELATED [GOC:TermGenie]
synonym: "down regulation of pentadecane biosynthesis" RELATED [GOC:TermGenie]
synonym: "down regulation of pentadecane biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of pentadecane formation" RELATED [GOC:TermGenie]
synonym: "down regulation of pentadecane synthesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of pentadecane anabolism" RELATED [GOC:TermGenie]
synonym: "down-regulation of pentadecane biosynthesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of pentadecane biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of pentadecane formation" RELATED [GOC:TermGenie]
synonym: "down-regulation of pentadecane synthesis" RELATED [GOC:TermGenie]
synonym: "downregulation of pentadecane anabolism" RELATED [GOC:TermGenie]
synonym: "downregulation of pentadecane biosynthesis" RELATED [GOC:TermGenie]
synonym: "downregulation of pentadecane biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of pentadecane formation" RELATED [GOC:TermGenie]
synonym: "downregulation of pentadecane synthesis" RELATED [GOC:TermGenie]
synonym: "inhibition of pentadecane anabolism" RELATED [GOC:TermGenie]
synonym: "inhibition of pentadecane biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of pentadecane biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of pentadecane formation" RELATED [GOC:TermGenie]
synonym: "inhibition of pentadecane synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of pentadecane anabolism" RELATED [GOC:TermGenie]
synonym: "negative regulation of pentadecane biosynthesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of pentadecane formation" RELATED [GOC:TermGenie]
synonym: "negative regulation of pentadecane synthesis" RELATED [GOC:TermGenie]
is_a: GO:1900887 ! regulation of pentadecane biosynthetic process
is_a: GO:1900891 ! negative regulation of pentadecane metabolic process
is_a: GO:1901578 ! negative regulation of alkane biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900634 ! pentadecane biosynthetic process
relationship: negatively_regulates GO:1900634 ! pentadecane biosynthetic process
created_by: tt
creation_date: 2012-06-13T03:03:57Z

[Term]
id: GO:1900889
name: positive regulation of pentadecane biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pentadecane biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of pentadecane anabolism" NARROW [GOC:TermGenie]
synonym: "activation of pentadecane biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of pentadecane biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of pentadecane formation" NARROW [GOC:TermGenie]
synonym: "activation of pentadecane synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of pentadecane anabolism" RELATED [GOC:TermGenie]
synonym: "positive regulation of pentadecane biosynthesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of pentadecane formation" RELATED [GOC:TermGenie]
synonym: "positive regulation of pentadecane synthesis" RELATED [GOC:TermGenie]
synonym: "up regulation of pentadecane anabolism" RELATED [GOC:TermGenie]
synonym: "up regulation of pentadecane biosynthesis" RELATED [GOC:TermGenie]
synonym: "up regulation of pentadecane biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of pentadecane formation" RELATED [GOC:TermGenie]
synonym: "up regulation of pentadecane synthesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of pentadecane anabolism" RELATED [GOC:TermGenie]
synonym: "up-regulation of pentadecane biosynthesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of pentadecane biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of pentadecane formation" RELATED [GOC:TermGenie]
synonym: "up-regulation of pentadecane synthesis" RELATED [GOC:TermGenie]
synonym: "upregulation of pentadecane anabolism" RELATED [GOC:TermGenie]
synonym: "upregulation of pentadecane biosynthesis" RELATED [GOC:TermGenie]
synonym: "upregulation of pentadecane biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of pentadecane formation" RELATED [GOC:TermGenie]
synonym: "upregulation of pentadecane synthesis" RELATED [GOC:TermGenie]
is_a: GO:1900887 ! regulation of pentadecane biosynthetic process
is_a: GO:1900892 ! positive regulation of pentadecane metabolic process
is_a: GO:1901579 ! positive regulation of alkane biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900634 ! pentadecane biosynthetic process
relationship: positively_regulates GO:1900634 ! pentadecane biosynthetic process
created_by: tt
creation_date: 2012-06-13T03:04:04Z

[Term]
id: GO:1900890
name: regulation of pentadecane metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pentadecane metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of pentadecane metabolism" EXACT [GOC:TermGenie]
is_a: GO:0031323 ! regulation of cellular metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900633 ! pentadecane metabolic process
relationship: regulates GO:1900633 ! pentadecane metabolic process
created_by: tt
creation_date: 2012-06-13T03:05:48Z

[Term]
id: GO:1900891
name: negative regulation of pentadecane metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of pentadecane metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of pentadecane metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of pentadecane metabolism" RELATED [GOC:TermGenie]
synonym: "down-regulation of pentadecane metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of pentadecane metabolism" RELATED [GOC:TermGenie]
synonym: "downregulation of pentadecane metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of pentadecane metabolism" RELATED [GOC:TermGenie]
synonym: "inhibition of pentadecane metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of pentadecane metabolism" NARROW [GOC:TermGenie]
synonym: "negative regulation of pentadecane metabolism" RELATED [GOC:TermGenie]
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:1900890 ! regulation of pentadecane metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900633 ! pentadecane metabolic process
relationship: negatively_regulates GO:1900633 ! pentadecane metabolic process
created_by: tt
creation_date: 2012-06-13T03:06:11Z

[Term]
id: GO:1900892
name: positive regulation of pentadecane metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pentadecane metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of pentadecane metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of pentadecane metabolism" NARROW [GOC:TermGenie]
synonym: "positive regulation of pentadecane metabolism" RELATED [GOC:TermGenie]
synonym: "up regulation of pentadecane metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of pentadecane metabolism" RELATED [GOC:TermGenie]
synonym: "up-regulation of pentadecane metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of pentadecane metabolism" RELATED [GOC:TermGenie]
synonym: "upregulation of pentadecane metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of pentadecane metabolism" RELATED [GOC:TermGenie]
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:1900890 ! regulation of pentadecane metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900633 ! pentadecane metabolic process
relationship: positively_regulates GO:1900633 ! pentadecane metabolic process
created_by: tt
creation_date: 2012-06-13T03:06:20Z

[Term]
id: GO:1900893
name: regulation of tridecane metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tridecane metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of tridecane metabolism" EXACT [GOC:TermGenie]
is_a: GO:0031323 ! regulation of cellular metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900631 ! tridecane metabolic process
relationship: regulates GO:1900631 ! tridecane metabolic process
created_by: tt
creation_date: 2012-06-13T03:14:40Z

[Term]
id: GO:1900894
name: negative regulation of tridecane metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tridecane metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of tridecane metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of tridecane metabolism" RELATED [GOC:TermGenie]
synonym: "down-regulation of tridecane metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of tridecane metabolism" RELATED [GOC:TermGenie]
synonym: "downregulation of tridecane metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of tridecane metabolism" RELATED [GOC:TermGenie]
synonym: "inhibition of tridecane metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of tridecane metabolism" NARROW [GOC:TermGenie]
synonym: "negative regulation of tridecane metabolism" RELATED [GOC:TermGenie]
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:1900893 ! regulation of tridecane metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900631 ! tridecane metabolic process
relationship: negatively_regulates GO:1900631 ! tridecane metabolic process
created_by: tt
creation_date: 2012-06-13T03:15:03Z

[Term]
id: GO:1900895
name: positive regulation of tridecane metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tridecane metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of tridecane metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of tridecane metabolism" NARROW [GOC:TermGenie]
synonym: "positive regulation of tridecane metabolism" RELATED [GOC:TermGenie]
synonym: "up regulation of tridecane metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of tridecane metabolism" RELATED [GOC:TermGenie]
synonym: "up-regulation of tridecane metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of tridecane metabolism" RELATED [GOC:TermGenie]
synonym: "upregulation of tridecane metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of tridecane metabolism" RELATED [GOC:TermGenie]
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:1900893 ! regulation of tridecane metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900631 ! tridecane metabolic process
relationship: positively_regulates GO:1900631 ! tridecane metabolic process
created_by: tt
creation_date: 2012-06-13T03:15:11Z

[Term]
id: GO:1900896
name: regulation of heptadecane biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of heptadecane biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of heptadecane anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of heptadecane biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of heptadecane formation" EXACT [GOC:TermGenie]
synonym: "regulation of heptadecane synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900899 ! regulation of heptadecane metabolic process
is_a: GO:1901577 ! regulation of alkane biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900636 ! heptadecane biosynthetic process
relationship: regulates GO:1900636 ! heptadecane biosynthetic process
created_by: tt
creation_date: 2012-06-13T03:27:38Z

[Term]
id: GO:1900897
name: negative regulation of heptadecane biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of heptadecane biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of heptadecane anabolism" RELATED [GOC:TermGenie]
synonym: "down regulation of heptadecane biosynthesis" RELATED [GOC:TermGenie]
synonym: "down regulation of heptadecane biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of heptadecane formation" RELATED [GOC:TermGenie]
synonym: "down regulation of heptadecane synthesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of heptadecane anabolism" RELATED [GOC:TermGenie]
synonym: "down-regulation of heptadecane biosynthesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of heptadecane biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of heptadecane formation" RELATED [GOC:TermGenie]
synonym: "down-regulation of heptadecane synthesis" RELATED [GOC:TermGenie]
synonym: "downregulation of heptadecane anabolism" RELATED [GOC:TermGenie]
synonym: "downregulation of heptadecane biosynthesis" RELATED [GOC:TermGenie]
synonym: "downregulation of heptadecane biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of heptadecane formation" RELATED [GOC:TermGenie]
synonym: "downregulation of heptadecane synthesis" RELATED [GOC:TermGenie]
synonym: "inhibition of heptadecane anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of heptadecane biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of heptadecane biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of heptadecane formation" NARROW [GOC:TermGenie]
synonym: "inhibition of heptadecane synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of heptadecane anabolism" RELATED [GOC:TermGenie]
synonym: "negative regulation of heptadecane biosynthesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of heptadecane formation" RELATED [GOC:TermGenie]
synonym: "negative regulation of heptadecane synthesis" RELATED [GOC:TermGenie]
is_a: GO:1900896 ! regulation of heptadecane biosynthetic process
is_a: GO:1900900 ! negative regulation of heptadecane metabolic process
is_a: GO:1901578 ! negative regulation of alkane biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900636 ! heptadecane biosynthetic process
relationship: negatively_regulates GO:1900636 ! heptadecane biosynthetic process
created_by: tt
creation_date: 2012-06-13T03:28:02Z

[Term]
id: GO:1900898
name: positive regulation of heptadecane biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of heptadecane biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of heptadecane anabolism" NARROW [GOC:TermGenie]
synonym: "activation of heptadecane biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of heptadecane biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of heptadecane formation" NARROW [GOC:TermGenie]
synonym: "activation of heptadecane synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of heptadecane anabolism" RELATED [GOC:TermGenie]
synonym: "positive regulation of heptadecane biosynthesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of heptadecane formation" RELATED [GOC:TermGenie]
synonym: "positive regulation of heptadecane synthesis" RELATED [GOC:TermGenie]
synonym: "up regulation of heptadecane anabolism" RELATED [GOC:TermGenie]
synonym: "up regulation of heptadecane biosynthesis" RELATED [GOC:TermGenie]
synonym: "up regulation of heptadecane biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of heptadecane formation" RELATED [GOC:TermGenie]
synonym: "up regulation of heptadecane synthesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of heptadecane anabolism" RELATED [GOC:TermGenie]
synonym: "up-regulation of heptadecane biosynthesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of heptadecane biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of heptadecane formation" RELATED [GOC:TermGenie]
synonym: "up-regulation of heptadecane synthesis" RELATED [GOC:TermGenie]
synonym: "upregulation of heptadecane anabolism" RELATED [GOC:TermGenie]
synonym: "upregulation of heptadecane biosynthesis" RELATED [GOC:TermGenie]
synonym: "upregulation of heptadecane biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of heptadecane formation" RELATED [GOC:TermGenie]
synonym: "upregulation of heptadecane synthesis" RELATED [GOC:TermGenie]
is_a: GO:1900896 ! regulation of heptadecane biosynthetic process
is_a: GO:1900901 ! positive regulation of heptadecane metabolic process
is_a: GO:1901579 ! positive regulation of alkane biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900636 ! heptadecane biosynthetic process
relationship: positively_regulates GO:1900636 ! heptadecane biosynthetic process
created_by: tt
creation_date: 2012-06-13T03:28:10Z

[Term]
id: GO:1900899
name: regulation of heptadecane metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of heptadecane metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of heptadecane metabolism" EXACT [GOC:TermGenie]
is_a: GO:0031323 ! regulation of cellular metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900635 ! heptadecane metabolic process
relationship: regulates GO:1900635 ! heptadecane metabolic process
created_by: tt
creation_date: 2012-06-13T03:30:03Z

[Term]
id: GO:1900900
name: negative regulation of heptadecane metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of heptadecane metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of heptadecane metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of heptadecane metabolism" RELATED [GOC:TermGenie]
synonym: "down-regulation of heptadecane metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of heptadecane metabolism" RELATED [GOC:TermGenie]
synonym: "downregulation of heptadecane metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of heptadecane metabolism" RELATED [GOC:TermGenie]
synonym: "inhibition of heptadecane metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of heptadecane metabolism" NARROW [GOC:TermGenie]
synonym: "negative regulation of heptadecane metabolism" RELATED [GOC:TermGenie]
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:1900899 ! regulation of heptadecane metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900635 ! heptadecane metabolic process
relationship: negatively_regulates GO:1900635 ! heptadecane metabolic process
created_by: tt
creation_date: 2012-06-13T03:30:25Z

[Term]
id: GO:1900901
name: positive regulation of heptadecane metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of heptadecane metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of heptadecane metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of heptadecane metabolism" NARROW [GOC:TermGenie]
synonym: "positive regulation of heptadecane metabolism" RELATED [GOC:TermGenie]
synonym: "up regulation of heptadecane metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of heptadecane metabolism" RELATED [GOC:TermGenie]
synonym: "up-regulation of heptadecane metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of heptadecane metabolism" RELATED [GOC:TermGenie]
synonym: "upregulation of heptadecane metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of heptadecane metabolism" RELATED [GOC:TermGenie]
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:1900899 ! regulation of heptadecane metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900635 ! heptadecane metabolic process
relationship: positively_regulates GO:1900635 ! heptadecane metabolic process
created_by: tt
creation_date: 2012-06-13T03:30:33Z

[Term]
id: GO:1900902
name: regulation of hexadecanal biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hexadecanal biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of hexadecanal anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of hexadecanal biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of hexadecanal formation" EXACT [GOC:TermGenie]
synonym: "regulation of hexadecanal synthesis" EXACT [GOC:TermGenie]
synonym: "regulation of palmitaldehyde biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of palmitaldehyde biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:1900905 ! regulation of hexadecanal metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006634 ! hexadecanal biosynthetic process
relationship: regulates GO:0006634 ! hexadecanal biosynthetic process
created_by: tt
creation_date: 2012-06-13T03:33:10Z

[Term]
id: GO:1900903
name: negative regulation of hexadecanal biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hexadecanal biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of hexadecanal anabolism" RELATED [GOC:TermGenie]
synonym: "down regulation of hexadecanal biosynthesis" RELATED [GOC:TermGenie]
synonym: "down regulation of hexadecanal biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of hexadecanal formation" RELATED [GOC:TermGenie]
synonym: "down regulation of hexadecanal synthesis" RELATED [GOC:TermGenie]
synonym: "down regulation of palmitaldehyde biosynthesis" RELATED [GOC:TermGenie]
synonym: "down regulation of palmitaldehyde biosynthetic process" RELATED [GOC:TermGenie]
synonym: "down-regulation of hexadecanal anabolism" RELATED [GOC:TermGenie]
synonym: "down-regulation of hexadecanal biosynthesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of hexadecanal biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of hexadecanal formation" RELATED [GOC:TermGenie]
synonym: "down-regulation of hexadecanal synthesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of palmitaldehyde biosynthesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of palmitaldehyde biosynthetic process" RELATED [GOC:TermGenie]
synonym: "downregulation of hexadecanal anabolism" RELATED [GOC:TermGenie]
synonym: "downregulation of hexadecanal biosynthesis" RELATED [GOC:TermGenie]
synonym: "downregulation of hexadecanal biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of hexadecanal formation" RELATED [GOC:TermGenie]
synonym: "downregulation of hexadecanal synthesis" RELATED [GOC:TermGenie]
synonym: "downregulation of palmitaldehyde biosynthesis" RELATED [GOC:TermGenie]
synonym: "downregulation of palmitaldehyde biosynthetic process" RELATED [GOC:TermGenie]
synonym: "inhibition of hexadecanal anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of hexadecanal biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of hexadecanal biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of hexadecanal formation" NARROW [GOC:TermGenie]
synonym: "inhibition of hexadecanal synthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of palmitaldehyde biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of palmitaldehyde biosynthetic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of hexadecanal anabolism" RELATED [GOC:TermGenie]
synonym: "negative regulation of hexadecanal biosynthesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of hexadecanal formation" RELATED [GOC:TermGenie]
synonym: "negative regulation of hexadecanal synthesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of palmitaldehyde biosynthesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of palmitaldehyde biosynthetic process" RELATED [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:1900902 ! regulation of hexadecanal biosynthetic process
is_a: GO:1900906 ! negative regulation of hexadecanal metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006634 ! hexadecanal biosynthetic process
relationship: negatively_regulates GO:0006634 ! hexadecanal biosynthetic process
created_by: tt
creation_date: 2012-06-13T03:33:34Z

[Term]
id: GO:1900904
name: positive regulation of hexadecanal biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hexadecanal biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of hexadecanal anabolism" NARROW [GOC:TermGenie]
synonym: "activation of hexadecanal biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of hexadecanal biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of hexadecanal formation" NARROW [GOC:TermGenie]
synonym: "activation of hexadecanal synthesis" NARROW [GOC:TermGenie]
synonym: "activation of palmitaldehyde biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of palmitaldehyde biosynthetic process" RELATED [GOC:TermGenie]
synonym: "positive regulation of hexadecanal anabolism" RELATED [GOC:TermGenie]
synonym: "positive regulation of hexadecanal biosynthesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of hexadecanal formation" RELATED [GOC:TermGenie]
synonym: "positive regulation of hexadecanal synthesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of palmitaldehyde biosynthesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of palmitaldehyde biosynthetic process" RELATED [GOC:TermGenie]
synonym: "up regulation of hexadecanal anabolism" RELATED [GOC:TermGenie]
synonym: "up regulation of hexadecanal biosynthesis" RELATED [GOC:TermGenie]
synonym: "up regulation of hexadecanal biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of hexadecanal formation" RELATED [GOC:TermGenie]
synonym: "up regulation of hexadecanal synthesis" RELATED [GOC:TermGenie]
synonym: "up regulation of palmitaldehyde biosynthesis" RELATED [GOC:TermGenie]
synonym: "up regulation of palmitaldehyde biosynthetic process" RELATED [GOC:TermGenie]
synonym: "up-regulation of hexadecanal anabolism" RELATED [GOC:TermGenie]
synonym: "up-regulation of hexadecanal biosynthesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of hexadecanal biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of hexadecanal formation" RELATED [GOC:TermGenie]
synonym: "up-regulation of hexadecanal synthesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of palmitaldehyde biosynthesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of palmitaldehyde biosynthetic process" RELATED [GOC:TermGenie]
synonym: "upregulation of hexadecanal anabolism" RELATED [GOC:TermGenie]
synonym: "upregulation of hexadecanal biosynthesis" RELATED [GOC:TermGenie]
synonym: "upregulation of hexadecanal biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of hexadecanal formation" RELATED [GOC:TermGenie]
synonym: "upregulation of hexadecanal synthesis" RELATED [GOC:TermGenie]
synonym: "upregulation of palmitaldehyde biosynthesis" RELATED [GOC:TermGenie]
synonym: "upregulation of palmitaldehyde biosynthetic process" RELATED [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:1900902 ! regulation of hexadecanal biosynthetic process
is_a: GO:1900907 ! positive regulation of hexadecanal metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006634 ! hexadecanal biosynthetic process
relationship: positively_regulates GO:0006634 ! hexadecanal biosynthetic process
created_by: tt
creation_date: 2012-06-13T03:33:42Z

[Term]
id: GO:1900905
name: regulation of hexadecanal metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hexadecanal metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of hexadecanal metabolism" EXACT [GOC:TermGenie]
is_a: GO:0031323 ! regulation of cellular metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0046458 ! hexadecanal metabolic process
relationship: regulates GO:0046458 ! hexadecanal metabolic process
created_by: tt
creation_date: 2012-06-13T03:35:27Z

[Term]
id: GO:1900906
name: negative regulation of hexadecanal metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hexadecanal metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of hexadecanal metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of hexadecanal metabolism" RELATED [GOC:TermGenie]
synonym: "down-regulation of hexadecanal metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of hexadecanal metabolism" RELATED [GOC:TermGenie]
synonym: "downregulation of hexadecanal metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of hexadecanal metabolism" RELATED [GOC:TermGenie]
synonym: "inhibition of hexadecanal metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of hexadecanal metabolism" RELATED [GOC:TermGenie]
synonym: "negative regulation of hexadecanal metabolism" RELATED [GOC:TermGenie]
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:1900905 ! regulation of hexadecanal metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0046458 ! hexadecanal metabolic process
relationship: negatively_regulates GO:0046458 ! hexadecanal metabolic process
created_by: tt
creation_date: 2012-06-13T03:35:54Z

[Term]
id: GO:1900907
name: positive regulation of hexadecanal metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hexadecanal metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of hexadecanal metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of hexadecanal metabolism" NARROW [GOC:TermGenie]
synonym: "positive regulation of hexadecanal metabolism" RELATED [GOC:TermGenie]
synonym: "up regulation of hexadecanal metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of hexadecanal metabolism" RELATED [GOC:TermGenie]
synonym: "up-regulation of hexadecanal metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of hexadecanal metabolism" RELATED [GOC:TermGenie]
synonym: "upregulation of hexadecanal metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of hexadecanal metabolism" RELATED [GOC:TermGenie]
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:1900905 ! regulation of hexadecanal metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0046458 ! hexadecanal metabolic process
relationship: positively_regulates GO:0046458 ! hexadecanal metabolic process
created_by: tt
creation_date: 2012-06-13T03:36:02Z

[Term]
id: GO:1900908
name: regulation of olefin metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of olefin metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of olefin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019222 ! regulation of metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900673 ! olefin metabolic process
relationship: regulates GO:1900673 ! olefin metabolic process
created_by: tt
creation_date: 2012-06-13T04:18:29Z

[Term]
id: GO:1900909
name: negative regulation of olefin metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of olefin metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of olefin metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of olefin metabolism" RELATED [GOC:TermGenie]
synonym: "down-regulation of olefin metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of olefin metabolism" RELATED [GOC:TermGenie]
synonym: "downregulation of olefin metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of olefin metabolism" RELATED [GOC:TermGenie]
synonym: "inhibition of olefin metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of olefin metabolism" RELATED [GOC:TermGenie]
synonym: "negative regulation of olefin metabolism" RELATED [GOC:TermGenie]
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:1900908 ! regulation of olefin metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900673 ! olefin metabolic process
relationship: negatively_regulates GO:1900673 ! olefin metabolic process
created_by: tt
creation_date: 2012-06-13T04:18:50Z

[Term]
id: GO:1900910
name: positive regulation of olefin metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of olefin metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of olefin metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of olefin metabolism" NARROW [GOC:TermGenie]
synonym: "positive regulation of olefin metabolism" RELATED [GOC:TermGenie]
synonym: "up regulation of olefin metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of olefin metabolism" RELATED [GOC:TermGenie]
synonym: "up-regulation of olefin metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of olefin metabolism" RELATED [GOC:TermGenie]
synonym: "upregulation of olefin metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of olefin metabolism" RELATED [GOC:TermGenie]
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:1900908 ! regulation of olefin metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900673 ! olefin metabolic process
relationship: positively_regulates GO:1900673 ! olefin metabolic process
created_by: tt
creation_date: 2012-06-13T04:18:58Z

[Term]
id: GO:1900911
name: regulation of olefin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of olefin biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of olefin anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of olefin biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of olefin formation" EXACT [GOC:TermGenie]
synonym: "regulation of olefin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:1900908 ! regulation of olefin metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900674 ! olefin biosynthetic process
relationship: regulates GO:1900674 ! olefin biosynthetic process
created_by: tt
creation_date: 2012-06-13T04:20:08Z

[Term]
id: GO:1900912
name: negative regulation of olefin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of olefin biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of olefin anabolism" RELATED [GOC:TermGenie]
synonym: "down regulation of olefin biosynthesis" RELATED [GOC:TermGenie]
synonym: "down regulation of olefin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of olefin formation" RELATED [GOC:TermGenie]
synonym: "down regulation of olefin synthesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of olefin anabolism" RELATED [GOC:TermGenie]
synonym: "down-regulation of olefin biosynthesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of olefin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of olefin formation" RELATED [GOC:TermGenie]
synonym: "down-regulation of olefin synthesis" RELATED [GOC:TermGenie]
synonym: "downregulation of olefin anabolism" RELATED [GOC:TermGenie]
synonym: "downregulation of olefin biosynthesis" RELATED [GOC:TermGenie]
synonym: "downregulation of olefin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of olefin formation" RELATED [GOC:TermGenie]
synonym: "downregulation of olefin synthesis" RELATED [GOC:TermGenie]
synonym: "inhibition of olefin anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of olefin biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of olefin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of olefin formation" NARROW [GOC:TermGenie]
synonym: "inhibition of olefin synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of olefin anabolism" RELATED [GOC:TermGenie]
synonym: "negative regulation of olefin biosynthesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of olefin formation" RELATED [GOC:TermGenie]
synonym: "negative regulation of olefin synthesis" RELATED [GOC:TermGenie]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:1900909 ! negative regulation of olefin metabolic process
is_a: GO:1900911 ! regulation of olefin biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900674 ! olefin biosynthetic process
relationship: negatively_regulates GO:1900674 ! olefin biosynthetic process
created_by: tt
creation_date: 2012-06-13T04:20:30Z

[Term]
id: GO:1900913
name: positive regulation of olefin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of olefin biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of olefin anabolism" NARROW [GOC:TermGenie]
synonym: "activation of olefin biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of olefin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of olefin formation" NARROW [GOC:TermGenie]
synonym: "activation of olefin synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of olefin anabolism" RELATED [GOC:TermGenie]
synonym: "positive regulation of olefin biosynthesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of olefin formation" RELATED [GOC:TermGenie]
synonym: "positive regulation of olefin synthesis" RELATED [GOC:TermGenie]
synonym: "up regulation of olefin anabolism" RELATED [GOC:TermGenie]
synonym: "up regulation of olefin biosynthesis" RELATED [GOC:TermGenie]
synonym: "up regulation of olefin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of olefin formation" RELATED [GOC:TermGenie]
synonym: "up regulation of olefin synthesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of olefin anabolism" RELATED [GOC:TermGenie]
synonym: "up-regulation of olefin biosynthesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of olefin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of olefin formation" RELATED [GOC:TermGenie]
synonym: "up-regulation of olefin synthesis" RELATED [GOC:TermGenie]
synonym: "upregulation of olefin anabolism" RELATED [GOC:TermGenie]
synonym: "upregulation of olefin biosynthesis" RELATED [GOC:TermGenie]
synonym: "upregulation of olefin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of olefin formation" RELATED [GOC:TermGenie]
synonym: "upregulation of olefin synthesis" RELATED [GOC:TermGenie]
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:1900910 ! positive regulation of olefin metabolic process
is_a: GO:1900911 ! regulation of olefin biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900674 ! olefin biosynthetic process
relationship: positively_regulates GO:1900674 ! olefin biosynthetic process
created_by: tt
creation_date: 2012-06-13T04:20:38Z

[Term]
id: GO:1900914
name: regulation of octadecene biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of octadecene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of 1-octadecene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "regulation of octadecene anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of octadecene biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of octadecene formation" EXACT [GOC:TermGenie]
synonym: "regulation of octadecene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:1900911 ! regulation of olefin biosynthetic process
is_a: GO:1900917 ! regulation of octadecene metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900682 ! octadecene biosynthetic process
relationship: regulates GO:1900682 ! octadecene biosynthetic process
created_by: tt
creation_date: 2012-06-13T04:24:24Z

[Term]
id: GO:1900915
name: negative regulation of octadecene biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of octadecene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of 1-octadecene biosynthetic process" RELATED [GOC:TermGenie]
synonym: "down regulation of octadecene anabolism" RELATED [GOC:TermGenie]
synonym: "down regulation of octadecene biosynthesis" RELATED [GOC:TermGenie]
synonym: "down regulation of octadecene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of octadecene formation" RELATED [GOC:TermGenie]
synonym: "down regulation of octadecene synthesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of 1-octadecene biosynthetic process" RELATED [GOC:TermGenie]
synonym: "down-regulation of octadecene anabolism" RELATED [GOC:TermGenie]
synonym: "down-regulation of octadecene biosynthesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of octadecene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of octadecene formation" RELATED [GOC:TermGenie]
synonym: "down-regulation of octadecene synthesis" RELATED [GOC:TermGenie]
synonym: "downregulation of 1-octadecene biosynthetic process" RELATED [GOC:TermGenie]
synonym: "downregulation of octadecene anabolism" RELATED [GOC:TermGenie]
synonym: "downregulation of octadecene biosynthesis" RELATED [GOC:TermGenie]
synonym: "downregulation of octadecene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of octadecene formation" RELATED [GOC:TermGenie]
synonym: "downregulation of octadecene synthesis" RELATED [GOC:TermGenie]
synonym: "inhibition of 1-octadecene biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of octadecene anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of octadecene biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of octadecene biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of octadecene formation" NARROW [GOC:TermGenie]
synonym: "inhibition of octadecene synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of 1-octadecene biosynthetic process" RELATED [GOC:TermGenie]
synonym: "negative regulation of octadecene anabolism" RELATED [GOC:TermGenie]
synonym: "negative regulation of octadecene biosynthesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of octadecene formation" RELATED [GOC:TermGenie]
synonym: "negative regulation of octadecene synthesis" RELATED [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:1900912 ! negative regulation of olefin biosynthetic process
is_a: GO:1900914 ! regulation of octadecene biosynthetic process
is_a: GO:1900918 ! negative regulation of octadecene metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900682 ! octadecene biosynthetic process
relationship: negatively_regulates GO:1900682 ! octadecene biosynthetic process
created_by: tt
creation_date: 2012-06-13T04:24:47Z

[Term]
id: GO:1900916
name: positive regulation of octadecene biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of octadecene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of 1-octadecene biosynthetic process" RELATED [GOC:TermGenie]
synonym: "activation of octadecene anabolism" RELATED [GOC:TermGenie]
synonym: "activation of octadecene biosynthesis" RELATED [GOC:TermGenie]
synonym: "activation of octadecene biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of octadecene formation" RELATED [GOC:TermGenie]
synonym: "activation of octadecene synthesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of 1-octadecene biosynthetic process" RELATED [GOC:TermGenie]
synonym: "positive regulation of octadecene anabolism" RELATED [GOC:TermGenie]
synonym: "positive regulation of octadecene biosynthesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of octadecene formation" RELATED [GOC:TermGenie]
synonym: "positive regulation of octadecene synthesis" RELATED [GOC:TermGenie]
synonym: "up regulation of 1-octadecene biosynthetic process" RELATED [GOC:TermGenie]
synonym: "up regulation of octadecene anabolism" RELATED [GOC:TermGenie]
synonym: "up regulation of octadecene biosynthesis" RELATED [GOC:TermGenie]
synonym: "up regulation of octadecene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of octadecene formation" RELATED [GOC:TermGenie]
synonym: "up regulation of octadecene synthesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of 1-octadecene biosynthetic process" RELATED [GOC:TermGenie]
synonym: "up-regulation of octadecene anabolism" RELATED [GOC:TermGenie]
synonym: "up-regulation of octadecene biosynthesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of octadecene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of octadecene formation" RELATED [GOC:TermGenie]
synonym: "up-regulation of octadecene synthesis" RELATED [GOC:TermGenie]
synonym: "upregulation of 1-octadecene biosynthetic process" RELATED [GOC:TermGenie]
synonym: "upregulation of octadecene anabolism" RELATED [GOC:TermGenie]
synonym: "upregulation of octadecene biosynthesis" RELATED [GOC:TermGenie]
synonym: "upregulation of octadecene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of octadecene formation" RELATED [GOC:TermGenie]
synonym: "upregulation of octadecene synthesis" RELATED [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:1900913 ! positive regulation of olefin biosynthetic process
is_a: GO:1900914 ! regulation of octadecene biosynthetic process
is_a: GO:1900919 ! positive regulation of octadecene metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900682 ! octadecene biosynthetic process
relationship: positively_regulates GO:1900682 ! octadecene biosynthetic process
created_by: tt
creation_date: 2012-06-13T04:24:55Z

[Term]
id: GO:1900917
name: regulation of octadecene metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of octadecene metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of octadecene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:1900908 ! regulation of olefin metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900681 ! octadecene metabolic process
relationship: regulates GO:1900681 ! octadecene metabolic process
created_by: tt
creation_date: 2012-06-13T04:26:11Z

[Term]
id: GO:1900918
name: negative regulation of octadecene metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of octadecene metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of octadecene metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of octadecene metabolism" RELATED [GOC:TermGenie]
synonym: "down-regulation of octadecene metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of octadecene metabolism" RELATED [GOC:TermGenie]
synonym: "downregulation of octadecene metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of octadecene metabolism" RELATED [GOC:TermGenie]
synonym: "inhibition of octadecene metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of octadecene metabolism" NARROW [GOC:TermGenie]
synonym: "negative regulation of octadecene metabolism" RELATED [GOC:TermGenie]
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:1900909 ! negative regulation of olefin metabolic process
is_a: GO:1900917 ! regulation of octadecene metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900681 ! octadecene metabolic process
relationship: negatively_regulates GO:1900681 ! octadecene metabolic process
created_by: tt
creation_date: 2012-06-13T04:26:34Z

[Term]
id: GO:1900919
name: positive regulation of octadecene metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of octadecene metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of octadecene metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of octadecene metabolism" NARROW [GOC:TermGenie]
synonym: "positive regulation of octadecene metabolism" RELATED [GOC:TermGenie]
synonym: "up regulation of octadecene metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of octadecene metabolism" RELATED [GOC:TermGenie]
synonym: "up-regulation of octadecene metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of octadecene metabolism" RELATED [GOC:TermGenie]
synonym: "upregulation of octadecene metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of octadecene metabolism" RELATED [GOC:TermGenie]
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:1900910 ! positive regulation of olefin metabolic process
is_a: GO:1900917 ! regulation of octadecene metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900681 ! octadecene metabolic process
relationship: positively_regulates GO:1900681 ! octadecene metabolic process
created_by: tt
creation_date: 2012-06-13T04:26:42Z

[Term]
id: GO:1900920
name: regulation of L-glutamate import
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of L-glutamate import." [GOC:TermGenie]
synonym: "regulation of L-glutamate uptake" EXACT [GOC:TermGenie]
is_a: GO:0002036 ! regulation of L-glutamate transport
is_a: GO:0010958 ! regulation of amino acid import
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051938 ! L-glutamate import
relationship: regulates GO:0051938 ! L-glutamate import
created_by: al
creation_date: 2012-06-13T07:34:08Z

[Term]
id: GO:1900921
name: negative regulation of L-glutamate import
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of L-glutamate import." [GOC:TermGenie]
synonym: "down regulation of L-glutamate import" EXACT [GOC:TermGenie]
synonym: "down regulation of L-glutamate uptake" RELATED [GOC:TermGenie]
synonym: "down-regulation of L-glutamate import" EXACT [GOC:TermGenie]
synonym: "down-regulation of L-glutamate uptake" RELATED [GOC:TermGenie]
synonym: "downregulation of L-glutamate import" EXACT [GOC:TermGenie]
synonym: "downregulation of L-glutamate uptake" RELATED [GOC:TermGenie]
synonym: "inhibition of L-glutamate import" NARROW [GOC:TermGenie]
synonym: "inhibition of L-glutamate uptake" NARROW [GOC:TermGenie]
synonym: "negative regulation of L-glutamate uptake" RELATED [GOC:TermGenie]
is_a: GO:0002037 ! negative regulation of L-glutamate transport
is_a: GO:1900920 ! regulation of L-glutamate import
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051938 ! L-glutamate import
relationship: negatively_regulates GO:0051938 ! L-glutamate import
created_by: al
creation_date: 2012-06-13T07:34:30Z

[Term]
id: GO:1900922
name: positive regulation of L-glutamate import
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of L-glutamate import." [GOC:TermGenie]
synonym: "activation of L-glutamate import" NARROW [GOC:TermGenie]
synonym: "activation of L-glutamate uptake" NARROW [GOC:TermGenie]
synonym: "positive regulation of L-glutamate uptake" RELATED [GOC:TermGenie]
synonym: "up regulation of L-glutamate import" EXACT [GOC:TermGenie]
synonym: "up regulation of L-glutamate uptake" RELATED [GOC:TermGenie]
synonym: "up-regulation of L-glutamate import" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-glutamate uptake" RELATED [GOC:TermGenie]
synonym: "upregulation of L-glutamate import" EXACT [GOC:TermGenie]
synonym: "upregulation of L-glutamate uptake" RELATED [GOC:TermGenie]
is_a: GO:0002038 ! positive regulation of L-glutamate transport
is_a: GO:1900920 ! regulation of L-glutamate import
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051938 ! L-glutamate import
relationship: positively_regulates GO:0051938 ! L-glutamate import
created_by: al
creation_date: 2012-06-13T07:34:38Z

[Term]
id: GO:1900923
name: regulation of glycine import
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glycine import." [GOC:TermGenie]
is_a: GO:0010958 ! regulation of amino acid import
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0036233 ! glycine import
relationship: regulates GO:0036233 ! glycine import
created_by: al
creation_date: 2012-06-13T07:40:11Z

[Term]
id: GO:1900924
name: negative regulation of glycine import
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glycine import." [GOC:TermGenie]
synonym: "down regulation of glycine import" EXACT [GOC:TermGenie]
synonym: "down-regulation of glycine import" EXACT [GOC:TermGenie]
synonym: "downregulation of glycine import" EXACT [GOC:TermGenie]
synonym: "inhibition of glycine import" NARROW [GOC:TermGenie]
is_a: GO:0051956 ! negative regulation of amino acid transport
is_a: GO:1900923 ! regulation of glycine import
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0036233 ! glycine import
relationship: negatively_regulates GO:0036233 ! glycine import
created_by: al
creation_date: 2012-06-13T07:40:32Z

[Term]
id: GO:1900925
name: positive regulation of glycine import
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glycine import." [GOC:TermGenie]
synonym: "activation of glycine import" NARROW [GOC:TermGenie]
synonym: "up regulation of glycine import" EXACT [GOC:TermGenie]
synonym: "up-regulation of glycine import" EXACT [GOC:TermGenie]
synonym: "upregulation of glycine import" EXACT [GOC:TermGenie]
is_a: GO:0051957 ! positive regulation of amino acid transport
is_a: GO:1900923 ! regulation of glycine import
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0036233 ! glycine import
relationship: positively_regulates GO:0036233 ! glycine import
created_by: al
creation_date: 2012-06-13T07:40:40Z

[Term]
id: GO:1900926
name: regulation of L-threonine import
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of L-threonine import." [GOC:TermGenie]
synonym: "regulation of L-threonine uptake" EXACT [GOC:TermGenie]
is_a: GO:0010958 ! regulation of amino acid import
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0036231 ! L-threonine import
relationship: regulates GO:0036231 ! L-threonine import
created_by: al
creation_date: 2012-06-13T07:41:32Z

[Term]
id: GO:1900927
name: negative regulation of L-threonine import
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of L-threonine import." [GOC:TermGenie]
synonym: "down regulation of L-threonine import" EXACT [GOC:TermGenie]
synonym: "down regulation of L-threonine uptake" RELATED [GOC:TermGenie]
synonym: "down-regulation of L-threonine import" EXACT [GOC:TermGenie]
synonym: "down-regulation of L-threonine uptake" RELATED [GOC:TermGenie]
synonym: "downregulation of L-threonine import" EXACT [GOC:TermGenie]
synonym: "downregulation of L-threonine uptake" RELATED [GOC:TermGenie]
synonym: "inhibition of L-threonine import" NARROW [GOC:TermGenie]
synonym: "inhibition of L-threonine uptake" NARROW [GOC:TermGenie]
synonym: "negative regulation of L-threonine uptake" RELATED [GOC:TermGenie]
is_a: GO:0051956 ! negative regulation of amino acid transport
is_a: GO:1900926 ! regulation of L-threonine import
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0036231 ! L-threonine import
relationship: negatively_regulates GO:0036231 ! L-threonine import
created_by: al
creation_date: 2012-06-13T07:41:52Z

[Term]
id: GO:1900928
name: positive regulation of L-threonine import
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of L-threonine import." [GOC:TermGenie]
synonym: "activation of L-threonine import" NARROW [GOC:TermGenie]
synonym: "activation of L-threonine uptake" NARROW [GOC:TermGenie]
synonym: "positive regulation of L-threonine uptake" RELATED [GOC:TermGenie]
synonym: "up regulation of L-threonine import" EXACT [GOC:TermGenie]
synonym: "up regulation of L-threonine uptake" RELATED [GOC:TermGenie]
synonym: "up-regulation of L-threonine import" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-threonine uptake" RELATED [GOC:TermGenie]
synonym: "upregulation of L-threonine import" EXACT [GOC:TermGenie]
synonym: "upregulation of L-threonine uptake" RELATED [GOC:TermGenie]
is_a: GO:0051957 ! positive regulation of amino acid transport
is_a: GO:1900926 ! regulation of L-threonine import
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0036231 ! L-threonine import
relationship: positively_regulates GO:0036231 ! L-threonine import
created_by: al
creation_date: 2012-06-13T07:42:00Z

[Term]
id: GO:1900929
name: regulation of L-tyrosine import
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of L-tyrosine import." [GOC:TermGenie]
synonym: "regulation of L-tyrosine uptake" EXACT [GOC:TermGenie]
is_a: GO:0010958 ! regulation of amino acid import
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0036232 ! L-tyrosine import
relationship: regulates GO:0036232 ! L-tyrosine import
created_by: al
creation_date: 2012-06-13T07:42:52Z

[Term]
id: GO:1900930
name: negative regulation of L-tyrosine import
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of L-tyrosine import." [GOC:TermGenie]
synonym: "down regulation of L-tyrosine import" EXACT [GOC:TermGenie]
synonym: "down regulation of L-tyrosine uptake" RELATED [GOC:TermGenie]
synonym: "down-regulation of L-tyrosine import" EXACT [GOC:TermGenie]
synonym: "down-regulation of L-tyrosine uptake" RELATED [GOC:TermGenie]
synonym: "downregulation of L-tyrosine import" EXACT [GOC:TermGenie]
synonym: "downregulation of L-tyrosine uptake" RELATED [GOC:TermGenie]
synonym: "inhibition of L-tyrosine import" NARROW [GOC:TermGenie]
synonym: "inhibition of L-tyrosine uptake" RELATED [GOC:TermGenie]
synonym: "negative regulation of L-tyrosine uptake" RELATED [GOC:TermGenie]
is_a: GO:0051956 ! negative regulation of amino acid transport
is_a: GO:1900929 ! regulation of L-tyrosine import
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0036232 ! L-tyrosine import
relationship: negatively_regulates GO:0036232 ! L-tyrosine import
created_by: al
creation_date: 2012-06-13T07:43:14Z

[Term]
id: GO:1900931
name: positive regulation of L-tyrosine import
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of L-tyrosine import." [GOC:TermGenie]
synonym: "activation of L-tyrosine import" NARROW [GOC:TermGenie]
synonym: "activation of L-tyrosine uptake" NARROW [GOC:TermGenie]
synonym: "positive regulation of L-tyrosine uptake" RELATED [GOC:TermGenie]
synonym: "up regulation of L-tyrosine import" EXACT [GOC:TermGenie]
synonym: "up regulation of L-tyrosine uptake" RELATED [GOC:TermGenie]
synonym: "up-regulation of L-tyrosine import" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-tyrosine uptake" RELATED [GOC:TermGenie]
synonym: "upregulation of L-tyrosine import" EXACT [GOC:TermGenie]
synonym: "upregulation of L-tyrosine uptake" RELATED [GOC:TermGenie]
is_a: GO:0051957 ! positive regulation of amino acid transport
is_a: GO:1900929 ! regulation of L-tyrosine import
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0036232 ! L-tyrosine import
relationship: positively_regulates GO:0036232 ! L-tyrosine import
created_by: al
creation_date: 2012-06-13T07:43:21Z

[Term]
id: GO:1900932
name: regulation of nonadec-1-ene metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nonadec-1-ene metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of nonadec-1-ene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:1900908 ! regulation of olefin metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900876 ! nonadec-1-ene metabolic process
relationship: regulates GO:1900876 ! nonadec-1-ene metabolic process
created_by: tt
creation_date: 2012-06-14T03:11:28Z

[Term]
id: GO:1900933
name: negative regulation of nonadec-1-ene metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of nonadec-1-ene metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of nonadec-1-ene metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of nonadec-1-ene metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of nonadec-1-ene metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of nonadec-1-ene metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of nonadec-1-ene metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of nonadec-1-ene metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of nonadec-1-ene metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of nonadec-1-ene metabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of nonadec-1-ene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:1900909 ! negative regulation of olefin metabolic process
is_a: GO:1900932 ! regulation of nonadec-1-ene metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900876 ! nonadec-1-ene metabolic process
relationship: negatively_regulates GO:1900876 ! nonadec-1-ene metabolic process
created_by: tt
creation_date: 2012-06-14T03:11:50Z

[Term]
id: GO:1900934
name: positive regulation of nonadec-1-ene metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of nonadec-1-ene metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of nonadec-1-ene metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of nonadec-1-ene metabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of nonadec-1-ene metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of nonadec-1-ene metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of nonadec-1-ene metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of nonadec-1-ene metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of nonadec-1-ene metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of nonadec-1-ene metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of nonadec-1-ene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:1900910 ! positive regulation of olefin metabolic process
is_a: GO:1900932 ! regulation of nonadec-1-ene metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900876 ! nonadec-1-ene metabolic process
relationship: positively_regulates GO:1900876 ! nonadec-1-ene metabolic process
created_by: tt
creation_date: 2012-06-14T03:11:58Z

[Term]
id: GO:1900935
name: regulation of nonadec-1-ene biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nonadec-1-ene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of nonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of nonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of nonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "regulation of nonadec-1-ene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:1900911 ! regulation of olefin biosynthetic process
is_a: GO:1900932 ! regulation of nonadec-1-ene metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900877 ! nonadec-1-ene biosynthetic process
relationship: regulates GO:1900877 ! nonadec-1-ene biosynthetic process
created_by: tt
creation_date: 2012-06-14T03:13:34Z

[Term]
id: GO:1900936
name: negative regulation of nonadec-1-ene biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of nonadec-1-ene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of nonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of nonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of nonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of nonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "down regulation of nonadec-1-ene synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of nonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of nonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of nonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of nonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of nonadec-1-ene synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of nonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of nonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of nonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of nonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "downregulation of nonadec-1-ene synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of nonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of nonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of nonadec-1-ene biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of nonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "inhibition of nonadec-1-ene synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of nonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of nonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of nonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of nonadec-1-ene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:1900912 ! negative regulation of olefin biosynthetic process
is_a: GO:1900933 ! negative regulation of nonadec-1-ene metabolic process
is_a: GO:1900935 ! regulation of nonadec-1-ene biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900877 ! nonadec-1-ene biosynthetic process
relationship: negatively_regulates GO:1900877 ! nonadec-1-ene biosynthetic process
created_by: tt
creation_date: 2012-06-14T03:13:56Z

[Term]
id: GO:1900937
name: positive regulation of nonadec-1-ene biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of nonadec-1-ene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of nonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "activation of nonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of nonadec-1-ene biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of nonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "activation of nonadec-1-ene synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of nonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of nonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of nonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of nonadec-1-ene synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of nonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of nonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of nonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of nonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "up regulation of nonadec-1-ene synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of nonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of nonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of nonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of nonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of nonadec-1-ene synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of nonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of nonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of nonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of nonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "upregulation of nonadec-1-ene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:1900913 ! positive regulation of olefin biosynthetic process
is_a: GO:1900934 ! positive regulation of nonadec-1-ene metabolic process
is_a: GO:1900935 ! regulation of nonadec-1-ene biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900877 ! nonadec-1-ene biosynthetic process
relationship: positively_regulates GO:1900877 ! nonadec-1-ene biosynthetic process
created_by: tt
creation_date: 2012-06-14T03:14:04Z

[Term]
id: GO:1900938
name: regulation of (Z)-nonadeca-1,14-diene metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of (Z)-nonadeca-1,14-diene metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of (Z)-nonadeca-1,14-diene metabolism" EXACT [GOC:TermGenie]
is_a: GO:1900908 ! regulation of olefin metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900878 ! (Z)-nonadeca-1,14-diene metabolic process
relationship: regulates GO:1900878 ! (Z)-nonadeca-1,14-diene metabolic process
created_by: tt
creation_date: 2012-06-14T03:15:37Z

[Term]
id: GO:1900939
name: negative regulation of (Z)-nonadeca-1,14-diene metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of (Z)-nonadeca-1,14-diene metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of (Z)-nonadeca-1,14-diene metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of (Z)-nonadeca-1,14-diene metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of (Z)-nonadeca-1,14-diene metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of (Z)-nonadeca-1,14-diene metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of (Z)-nonadeca-1,14-diene metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of (Z)-nonadeca-1,14-diene metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of (Z)-nonadeca-1,14-diene metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of (Z)-nonadeca-1,14-diene metabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of (Z)-nonadeca-1,14-diene metabolism" EXACT [GOC:TermGenie]
is_a: GO:1900909 ! negative regulation of olefin metabolic process
is_a: GO:1900938 ! regulation of (Z)-nonadeca-1,14-diene metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900878 ! (Z)-nonadeca-1,14-diene metabolic process
relationship: negatively_regulates GO:1900878 ! (Z)-nonadeca-1,14-diene metabolic process
created_by: tt
creation_date: 2012-06-14T03:15:58Z

[Term]
id: GO:1900940
name: positive regulation of (Z)-nonadeca-1,14-diene metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of (Z)-nonadeca-1,14-diene metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of (Z)-nonadeca-1,14-diene metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of (Z)-nonadeca-1,14-diene metabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of (Z)-nonadeca-1,14-diene metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of (Z)-nonadeca-1,14-diene metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of (Z)-nonadeca-1,14-diene metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of (Z)-nonadeca-1,14-diene metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of (Z)-nonadeca-1,14-diene metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of (Z)-nonadeca-1,14-diene metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of (Z)-nonadeca-1,14-diene metabolism" EXACT [GOC:TermGenie]
is_a: GO:1900910 ! positive regulation of olefin metabolic process
is_a: GO:1900938 ! regulation of (Z)-nonadeca-1,14-diene metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900878 ! (Z)-nonadeca-1,14-diene metabolic process
relationship: positively_regulates GO:1900878 ! (Z)-nonadeca-1,14-diene metabolic process
created_by: tt
creation_date: 2012-06-14T03:16:05Z

[Term]
id: GO:1900941
name: regulation of (Z)-nonadeca-1,14-diene biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of (Z)-nonadeca-1,14-diene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of (Z)-nonadeca-1,14-diene anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of (Z)-nonadeca-1,14-diene biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of (Z)-nonadeca-1,14-diene formation" EXACT [GOC:TermGenie]
synonym: "regulation of (Z)-nonadeca-1,14-diene synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900911 ! regulation of olefin biosynthetic process
is_a: GO:1900938 ! regulation of (Z)-nonadeca-1,14-diene metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900879 ! (Z)-nonadeca-1,14-diene biosynthetic process
relationship: regulates GO:1900879 ! (Z)-nonadeca-1,14-diene biosynthetic process
created_by: tt
creation_date: 2012-06-14T03:17:32Z

[Term]
id: GO:1900942
name: negative regulation of (Z)-nonadeca-1,14-diene biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of (Z)-nonadeca-1,14-diene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of (Z)-nonadeca-1,14-diene anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of (Z)-nonadeca-1,14-diene biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of (Z)-nonadeca-1,14-diene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of (Z)-nonadeca-1,14-diene formation" EXACT [GOC:TermGenie]
synonym: "down regulation of (Z)-nonadeca-1,14-diene synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of (Z)-nonadeca-1,14-diene anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of (Z)-nonadeca-1,14-diene biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of (Z)-nonadeca-1,14-diene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of (Z)-nonadeca-1,14-diene formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of (Z)-nonadeca-1,14-diene synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of (Z)-nonadeca-1,14-diene anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of (Z)-nonadeca-1,14-diene biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of (Z)-nonadeca-1,14-diene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of (Z)-nonadeca-1,14-diene formation" EXACT [GOC:TermGenie]
synonym: "downregulation of (Z)-nonadeca-1,14-diene synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of (Z)-nonadeca-1,14-diene anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of (Z)-nonadeca-1,14-diene biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of (Z)-nonadeca-1,14-diene biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of (Z)-nonadeca-1,14-diene formation" NARROW [GOC:TermGenie]
synonym: "inhibition of (Z)-nonadeca-1,14-diene synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of (Z)-nonadeca-1,14-diene anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of (Z)-nonadeca-1,14-diene biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of (Z)-nonadeca-1,14-diene formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of (Z)-nonadeca-1,14-diene synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900912 ! negative regulation of olefin biosynthetic process
is_a: GO:1900939 ! negative regulation of (Z)-nonadeca-1,14-diene metabolic process
is_a: GO:1900941 ! regulation of (Z)-nonadeca-1,14-diene biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900879 ! (Z)-nonadeca-1,14-diene biosynthetic process
relationship: negatively_regulates GO:1900879 ! (Z)-nonadeca-1,14-diene biosynthetic process
created_by: tt
creation_date: 2012-06-14T03:17:54Z

[Term]
id: GO:1900943
name: positive regulation of (Z)-nonadeca-1,14-diene biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of (Z)-nonadeca-1,14-diene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of (Z)-nonadeca-1,14-diene anabolism" NARROW [GOC:TermGenie]
synonym: "activation of (Z)-nonadeca-1,14-diene biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of (Z)-nonadeca-1,14-diene biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of (Z)-nonadeca-1,14-diene formation" NARROW [GOC:TermGenie]
synonym: "activation of (Z)-nonadeca-1,14-diene synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of (Z)-nonadeca-1,14-diene anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of (Z)-nonadeca-1,14-diene biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of (Z)-nonadeca-1,14-diene formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of (Z)-nonadeca-1,14-diene synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of (Z)-nonadeca-1,14-diene anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of (Z)-nonadeca-1,14-diene biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of (Z)-nonadeca-1,14-diene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of (Z)-nonadeca-1,14-diene formation" EXACT [GOC:TermGenie]
synonym: "up regulation of (Z)-nonadeca-1,14-diene synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of (Z)-nonadeca-1,14-diene anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of (Z)-nonadeca-1,14-diene biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of (Z)-nonadeca-1,14-diene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of (Z)-nonadeca-1,14-diene formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of (Z)-nonadeca-1,14-diene synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of (Z)-nonadeca-1,14-diene anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of (Z)-nonadeca-1,14-diene biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of (Z)-nonadeca-1,14-diene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of (Z)-nonadeca-1,14-diene formation" EXACT [GOC:TermGenie]
synonym: "upregulation of (Z)-nonadeca-1,14-diene synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900913 ! positive regulation of olefin biosynthetic process
is_a: GO:1900940 ! positive regulation of (Z)-nonadeca-1,14-diene metabolic process
is_a: GO:1900941 ! regulation of (Z)-nonadeca-1,14-diene biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900879 ! (Z)-nonadeca-1,14-diene biosynthetic process
relationship: positively_regulates GO:1900879 ! (Z)-nonadeca-1,14-diene biosynthetic process
created_by: tt
creation_date: 2012-06-14T03:18:01Z

[Term]
id: GO:1900944
name: regulation of isoprene metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of isoprene metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of 2-methyl-1,3-butadiene metabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of 2-methyl-1,3-butadiene metabolism" EXACT [GOC:TermGenie]
synonym: "regulation of hemiterpene metabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of hemiterpene metabolism" EXACT [GOC:TermGenie]
synonym: "regulation of isoprene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019747 ! regulation of isoprenoid metabolic process
is_a: GO:1900908 ! regulation of olefin metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043611 ! isoprene metabolic process
relationship: regulates GO:0043611 ! isoprene metabolic process
created_by: tt
creation_date: 2012-06-14T03:19:13Z

[Term]
id: GO:1900945
name: negative regulation of isoprene metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of isoprene metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of 2-methyl-1,3-butadiene metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of 2-methyl-1,3-butadiene metabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of hemiterpene metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of hemiterpene metabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of isoprene metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of isoprene metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of 2-methyl-1,3-butadiene metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of 2-methyl-1,3-butadiene metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of hemiterpene metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of hemiterpene metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of isoprene metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of isoprene metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of 2-methyl-1,3-butadiene metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of 2-methyl-1,3-butadiene metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of hemiterpene metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of hemiterpene metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of isoprene metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of isoprene metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of 2-methyl-1,3-butadiene metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of 2-methyl-1,3-butadiene metabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of hemiterpene metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of hemiterpene metabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of isoprene metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of isoprene metabolism" NARROW [GOC:TermGenie]
synonym: "negative regulation of 2-methyl-1,3-butadiene metabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of 2-methyl-1,3-butadiene metabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of hemiterpene metabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of hemiterpene metabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of isoprene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0045827 ! negative regulation of isoprenoid metabolic process
is_a: GO:1900909 ! negative regulation of olefin metabolic process
is_a: GO:1900944 ! regulation of isoprene metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043611 ! isoprene metabolic process
relationship: negatively_regulates GO:0043611 ! isoprene metabolic process
created_by: tt
creation_date: 2012-06-14T03:19:33Z

[Term]
id: GO:1900946
name: positive regulation of isoprene metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of isoprene metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of 2-methyl-1,3-butadiene metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of 2-methyl-1,3-butadiene metabolism" NARROW [GOC:TermGenie]
synonym: "activation of hemiterpene metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of hemiterpene metabolism" NARROW [GOC:TermGenie]
synonym: "activation of isoprene metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of isoprene metabolism" NARROW [GOC:TermGenie]
synonym: "positive regulation of 2-methyl-1,3-butadiene metabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of 2-methyl-1,3-butadiene metabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of hemiterpene metabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of hemiterpene metabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of isoprene metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of 2-methyl-1,3-butadiene metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of 2-methyl-1,3-butadiene metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of hemiterpene metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of hemiterpene metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of isoprene metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of isoprene metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of 2-methyl-1,3-butadiene metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of 2-methyl-1,3-butadiene metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of hemiterpene metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of hemiterpene metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of isoprene metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of isoprene metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of 2-methyl-1,3-butadiene metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of 2-methyl-1,3-butadiene metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of hemiterpene metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of hemiterpene metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of isoprene metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of isoprene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process
is_a: GO:1900910 ! positive regulation of olefin metabolic process
is_a: GO:1900944 ! regulation of isoprene metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043611 ! isoprene metabolic process
relationship: positively_regulates GO:0043611 ! isoprene metabolic process
created_by: tt
creation_date: 2012-06-14T03:19:41Z

[Term]
id: GO:1900947
name: regulation of isoprene biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of isoprene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of 2-methyl-1,3-butadiene biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of 2-methyl-1,3-butadiene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "regulation of hemiterpene biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of hemiterpene biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0046890 ! regulation of lipid biosynthetic process
is_a: GO:1900911 ! regulation of olefin biosynthetic process
is_a: GO:1900944 ! regulation of isoprene metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043612 ! isoprene biosynthetic process
relationship: regulates GO:0043612 ! isoprene biosynthetic process
created_by: tt
creation_date: 2012-06-14T03:21:26Z

[Term]
id: GO:1900948
name: negative regulation of isoprene biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of isoprene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of 2-methyl-1,3-butadiene biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of 2-methyl-1,3-butadiene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of hemiterpene biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of hemiterpene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of isoprene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of 2-methyl-1,3-butadiene biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of 2-methyl-1,3-butadiene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of hemiterpene biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of hemiterpene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of isoprene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of 2-methyl-1,3-butadiene biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of 2-methyl-1,3-butadiene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of hemiterpene biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of hemiterpene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of isoprene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "inhibition of 2-methyl-1,3-butadiene biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of 2-methyl-1,3-butadiene biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of hemiterpene biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of hemiterpene biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of isoprene biosynthetic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of 2-methyl-1,3-butadiene biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of 2-methyl-1,3-butadiene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of hemiterpene biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of hemiterpene biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0051055 ! negative regulation of lipid biosynthetic process
is_a: GO:1900912 ! negative regulation of olefin biosynthetic process
is_a: GO:1900945 ! negative regulation of isoprene metabolic process
is_a: GO:1900947 ! regulation of isoprene biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043612 ! isoprene biosynthetic process
relationship: negatively_regulates GO:0043612 ! isoprene biosynthetic process
created_by: tt
creation_date: 2012-06-14T03:21:47Z

[Term]
id: GO:1900949
name: positive regulation of isoprene biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of isoprene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of 2-methyl-1,3-butadiene biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of 2-methyl-1,3-butadiene biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of hemiterpene biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of hemiterpene biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of isoprene biosynthetic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of 2-methyl-1,3-butadiene biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of 2-methyl-1,3-butadiene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of hemiterpene biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of hemiterpene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of 2-methyl-1,3-butadiene biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of 2-methyl-1,3-butadiene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of hemiterpene biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of hemiterpene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of isoprene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of 2-methyl-1,3-butadiene biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of 2-methyl-1,3-butadiene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of hemiterpene biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of hemiterpene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of isoprene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of 2-methyl-1,3-butadiene biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of 2-methyl-1,3-butadiene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of hemiterpene biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of hemiterpene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of isoprene biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0046889 ! positive regulation of lipid biosynthetic process
is_a: GO:1900913 ! positive regulation of olefin biosynthetic process
is_a: GO:1900946 ! positive regulation of isoprene metabolic process
is_a: GO:1900947 ! regulation of isoprene biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043612 ! isoprene biosynthetic process
relationship: positively_regulates GO:0043612 ! isoprene biosynthetic process
created_by: tt
creation_date: 2012-06-14T03:21:54Z

[Term]
id: GO:1900950
name: regulation of 18-methylnonadec-1-ene biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of 18-methylnonadec-1-ene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of 18-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of 18-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of 18-methylnonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "regulation of 18-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:1900911 ! regulation of olefin biosynthetic process
is_a: GO:1900953 ! regulation of 18-methylnonadec-1-ene metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900881 ! 18-methylnonadec-1-ene biosynthetic process
relationship: regulates GO:1900881 ! 18-methylnonadec-1-ene biosynthetic process
created_by: tt
creation_date: 2012-06-14T03:23:34Z

[Term]
id: GO:1900951
name: negative regulation of 18-methylnonadec-1-ene biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of 18-methylnonadec-1-ene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of 18-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of 18-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of 18-methylnonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of 18-methylnonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "down regulation of 18-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of 18-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of 18-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of 18-methylnonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of 18-methylnonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of 18-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of 18-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of 18-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of 18-methylnonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of 18-methylnonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "downregulation of 18-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of 18-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of 18-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of 18-methylnonadec-1-ene biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of 18-methylnonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "inhibition of 18-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of 18-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of 18-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of 18-methylnonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of 18-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:1900912 ! negative regulation of olefin biosynthetic process
is_a: GO:1900950 ! regulation of 18-methylnonadec-1-ene biosynthetic process
is_a: GO:1900954 ! negative regulation of 18-methylnonadec-1-ene metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900881 ! 18-methylnonadec-1-ene biosynthetic process
relationship: negatively_regulates GO:1900881 ! 18-methylnonadec-1-ene biosynthetic process
created_by: tt
creation_date: 2012-06-14T03:23:55Z

[Term]
id: GO:1900952
name: positive regulation of 18-methylnonadec-1-ene biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of 18-methylnonadec-1-ene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of 18-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "activation of 18-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of 18-methylnonadec-1-ene biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of 18-methylnonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "activation of 18-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of 18-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of 18-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of 18-methylnonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of 18-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of 18-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of 18-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of 18-methylnonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of 18-methylnonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "up regulation of 18-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of 18-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of 18-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of 18-methylnonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of 18-methylnonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of 18-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of 18-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of 18-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of 18-methylnonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of 18-methylnonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "upregulation of 18-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:1900913 ! positive regulation of olefin biosynthetic process
is_a: GO:1900950 ! regulation of 18-methylnonadec-1-ene biosynthetic process
is_a: GO:1900955 ! positive regulation of 18-methylnonadec-1-ene metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900881 ! 18-methylnonadec-1-ene biosynthetic process
relationship: positively_regulates GO:1900881 ! 18-methylnonadec-1-ene biosynthetic process
created_by: tt
creation_date: 2012-06-14T03:24:02Z

[Term]
id: GO:1900953
name: regulation of 18-methylnonadec-1-ene metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of 18-methylnonadec-1-ene metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of 18-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:1900908 ! regulation of olefin metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900880 ! 18-methylnonadec-1-ene metabolic process
relationship: regulates GO:1900880 ! 18-methylnonadec-1-ene metabolic process
created_by: tt
creation_date: 2012-06-14T03:25:16Z

[Term]
id: GO:1900954
name: negative regulation of 18-methylnonadec-1-ene metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of 18-methylnonadec-1-ene metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of 18-methylnonadec-1-ene metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of 18-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of 18-methylnonadec-1-ene metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of 18-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of 18-methylnonadec-1-ene metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of 18-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of 18-methylnonadec-1-ene metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of 18-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of 18-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:1900909 ! negative regulation of olefin metabolic process
is_a: GO:1900953 ! regulation of 18-methylnonadec-1-ene metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900880 ! 18-methylnonadec-1-ene metabolic process
relationship: negatively_regulates GO:1900880 ! 18-methylnonadec-1-ene metabolic process
created_by: tt
creation_date: 2012-06-14T03:25:37Z

[Term]
id: GO:1900955
name: positive regulation of 18-methylnonadec-1-ene metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of 18-methylnonadec-1-ene metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of 18-methylnonadec-1-ene metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of 18-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of 18-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of 18-methylnonadec-1-ene metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of 18-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of 18-methylnonadec-1-ene metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of 18-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of 18-methylnonadec-1-ene metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of 18-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:1900910 ! positive regulation of olefin metabolic process
is_a: GO:1900953 ! regulation of 18-methylnonadec-1-ene metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900880 ! 18-methylnonadec-1-ene metabolic process
relationship: positively_regulates GO:1900880 ! 18-methylnonadec-1-ene metabolic process
created_by: tt
creation_date: 2012-06-14T03:25:44Z

[Term]
id: GO:1900956
name: regulation of 17-methylnonadec-1-ene biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of 17-methylnonadec-1-ene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of 17-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of 17-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of 17-methylnonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "regulation of 17-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:1900911 ! regulation of olefin biosynthetic process
is_a: GO:1900959 ! regulation of 17-methylnonadec-1-ene metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900883 ! 17-methylnonadec-1-ene biosynthetic process
relationship: regulates GO:1900883 ! 17-methylnonadec-1-ene biosynthetic process
created_by: tt
creation_date: 2012-06-14T03:27:18Z

[Term]
id: GO:1900957
name: negative regulation of 17-methylnonadec-1-ene biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of 17-methylnonadec-1-ene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of 17-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of 17-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of 17-methylnonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of 17-methylnonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "down regulation of 17-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of 17-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of 17-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of 17-methylnonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of 17-methylnonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of 17-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of 17-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of 17-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of 17-methylnonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of 17-methylnonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "downregulation of 17-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of 17-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of 17-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of 17-methylnonadec-1-ene biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of 17-methylnonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "inhibition of 17-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of 17-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of 17-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of 17-methylnonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of 17-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:1900912 ! negative regulation of olefin biosynthetic process
is_a: GO:1900956 ! regulation of 17-methylnonadec-1-ene biosynthetic process
is_a: GO:1900960 ! negative regulation of 17-methylnonadec-1-ene metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900883 ! 17-methylnonadec-1-ene biosynthetic process
relationship: negatively_regulates GO:1900883 ! 17-methylnonadec-1-ene biosynthetic process
created_by: tt
creation_date: 2012-06-14T03:27:39Z

[Term]
id: GO:1900958
name: positive regulation of 17-methylnonadec-1-ene biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of 17-methylnonadec-1-ene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of 17-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "activation of 17-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of 17-methylnonadec-1-ene biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of 17-methylnonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "activation of 17-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of 17-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of 17-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of 17-methylnonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of 17-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of 17-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of 17-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of 17-methylnonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of 17-methylnonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "up regulation of 17-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of 17-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of 17-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of 17-methylnonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of 17-methylnonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of 17-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of 17-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of 17-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of 17-methylnonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of 17-methylnonadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "upregulation of 17-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:1900913 ! positive regulation of olefin biosynthetic process
is_a: GO:1900956 ! regulation of 17-methylnonadec-1-ene biosynthetic process
is_a: GO:1900961 ! positive regulation of 17-methylnonadec-1-ene metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900883 ! 17-methylnonadec-1-ene biosynthetic process
relationship: positively_regulates GO:1900883 ! 17-methylnonadec-1-ene biosynthetic process
created_by: tt
creation_date: 2012-06-14T03:27:46Z

[Term]
id: GO:1900959
name: regulation of 17-methylnonadec-1-ene metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of 17-methylnonadec-1-ene metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of 17-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:1900908 ! regulation of olefin metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900882 ! 17-methylnonadec-1-ene metabolic process
relationship: regulates GO:1900882 ! 17-methylnonadec-1-ene metabolic process
created_by: tt
creation_date: 2012-06-14T03:29:27Z

[Term]
id: GO:1900960
name: negative regulation of 17-methylnonadec-1-ene metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of 17-methylnonadec-1-ene metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of 17-methylnonadec-1-ene metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of 17-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of 17-methylnonadec-1-ene metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of 17-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of 17-methylnonadec-1-ene metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of 17-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of 17-methylnonadec-1-ene metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of 17-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of 17-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:1900909 ! negative regulation of olefin metabolic process
is_a: GO:1900959 ! regulation of 17-methylnonadec-1-ene metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900882 ! 17-methylnonadec-1-ene metabolic process
relationship: negatively_regulates GO:1900882 ! 17-methylnonadec-1-ene metabolic process
created_by: tt
creation_date: 2012-06-14T03:29:51Z

[Term]
id: GO:1900961
name: positive regulation of 17-methylnonadec-1-ene metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of 17-methylnonadec-1-ene metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of 17-methylnonadec-1-ene metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of 17-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of 17-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of 17-methylnonadec-1-ene metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of 17-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of 17-methylnonadec-1-ene metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of 17-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of 17-methylnonadec-1-ene metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of 17-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:1900910 ! positive regulation of olefin metabolic process
is_a: GO:1900959 ! regulation of 17-methylnonadec-1-ene metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900882 ! 17-methylnonadec-1-ene metabolic process
relationship: positively_regulates GO:1900882 ! 17-methylnonadec-1-ene metabolic process
created_by: tt
creation_date: 2012-06-14T03:29:59Z

[Term]
id: GO:1900962
name: regulation of methanophenazine biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of methanophenazine biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of methanophenazine anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of methanophenazine biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of methanophenazine formation" EXACT [GOC:TermGenie]
synonym: "regulation of methanophenazine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:1900965 ! regulation of methanophenazine metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900630 ! methanophenazine biosynthetic process
relationship: regulates GO:1900630 ! methanophenazine biosynthetic process
created_by: tt
creation_date: 2012-06-14T03:53:15Z

[Term]
id: GO:1900963
name: negative regulation of methanophenazine biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of methanophenazine biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of methanophenazine anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of methanophenazine biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of methanophenazine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of methanophenazine formation" EXACT [GOC:TermGenie]
synonym: "down regulation of methanophenazine synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of methanophenazine anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of methanophenazine biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of methanophenazine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of methanophenazine formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of methanophenazine synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of methanophenazine anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of methanophenazine biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of methanophenazine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of methanophenazine formation" EXACT [GOC:TermGenie]
synonym: "downregulation of methanophenazine synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of methanophenazine anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of methanophenazine biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of methanophenazine biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of methanophenazine formation" EXACT [GOC:TermGenie]
synonym: "inhibition of methanophenazine synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of methanophenazine anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of methanophenazine biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of methanophenazine formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of methanophenazine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:1900962 ! regulation of methanophenazine biosynthetic process
is_a: GO:1900966 ! negative regulation of methanophenazine metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900630 ! methanophenazine biosynthetic process
relationship: negatively_regulates GO:1900630 ! methanophenazine biosynthetic process
created_by: tt
creation_date: 2012-06-14T03:53:38Z

[Term]
id: GO:1900964
name: positive regulation of methanophenazine biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of methanophenazine biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of methanophenazine anabolism" EXACT [GOC:TermGenie]
synonym: "activation of methanophenazine biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of methanophenazine biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of methanophenazine formation" EXACT [GOC:TermGenie]
synonym: "activation of methanophenazine synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of methanophenazine anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of methanophenazine biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of methanophenazine formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of methanophenazine synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of methanophenazine anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of methanophenazine biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of methanophenazine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of methanophenazine formation" EXACT [GOC:TermGenie]
synonym: "up regulation of methanophenazine synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of methanophenazine anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of methanophenazine biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of methanophenazine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of methanophenazine formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of methanophenazine synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of methanophenazine anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of methanophenazine biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of methanophenazine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of methanophenazine formation" EXACT [GOC:TermGenie]
synonym: "upregulation of methanophenazine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:1900962 ! regulation of methanophenazine biosynthetic process
is_a: GO:1900967 ! positive regulation of methanophenazine metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900630 ! methanophenazine biosynthetic process
relationship: positively_regulates GO:1900630 ! methanophenazine biosynthetic process
created_by: tt
creation_date: 2012-06-14T03:53:46Z

[Term]
id: GO:1900965
name: regulation of methanophenazine metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of methanophenazine metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of methanophenazine metabolism" EXACT [GOC:TermGenie]
is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900629 ! methanophenazine metabolic process
relationship: regulates GO:1900629 ! methanophenazine metabolic process
created_by: tt
creation_date: 2012-06-14T03:55:26Z

[Term]
id: GO:1900966
name: negative regulation of methanophenazine metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of methanophenazine metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of methanophenazine metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of methanophenazine metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of methanophenazine metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of methanophenazine metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of methanophenazine metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of methanophenazine metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of methanophenazine metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of methanophenazine metabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of methanophenazine metabolism" EXACT [GOC:TermGenie]
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process
is_a: GO:1900965 ! regulation of methanophenazine metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900629 ! methanophenazine metabolic process
relationship: negatively_regulates GO:1900629 ! methanophenazine metabolic process
created_by: tt
creation_date: 2012-06-14T03:55:49Z

[Term]
id: GO:1900967
name: positive regulation of methanophenazine metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of methanophenazine metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of methanophenazine metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of methanophenazine metabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of methanophenazine metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of methanophenazine metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of methanophenazine metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of methanophenazine metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of methanophenazine metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of methanophenazine metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of methanophenazine metabolism" EXACT [GOC:TermGenie]
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process
is_a: GO:1900965 ! regulation of methanophenazine metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900629 ! methanophenazine metabolic process
relationship: positively_regulates GO:1900629 ! methanophenazine metabolic process
created_by: tt
creation_date: 2012-06-14T03:55:56Z

[Term]
id: GO:1900968
name: regulation of sarcinapterin metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sarcinapterin metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of sarcinapterin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019220 ! regulation of phosphate metabolic process
is_a: GO:0042068 ! regulation of pteridine metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900867 ! sarcinapterin metabolic process
relationship: regulates GO:1900867 ! sarcinapterin metabolic process
created_by: tt
creation_date: 2012-06-14T03:58:11Z

[Term]
id: GO:1900969
name: negative regulation of sarcinapterin metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sarcinapterin metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of sarcinapterin metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of sarcinapterin metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of sarcinapterin metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of sarcinapterin metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of sarcinapterin metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of sarcinapterin metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of sarcinapterin metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of sarcinapterin metabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of sarcinapterin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0045863 ! negative regulation of pteridine metabolic process
is_a: GO:0045936 ! negative regulation of phosphate metabolic process
is_a: GO:1900968 ! regulation of sarcinapterin metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900867 ! sarcinapterin metabolic process
relationship: negatively_regulates GO:1900867 ! sarcinapterin metabolic process
created_by: tt
creation_date: 2012-06-14T03:58:35Z

[Term]
id: GO:1900970
name: positive regulation of sarcinapterin metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sarcinapterin metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of sarcinapterin metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of sarcinapterin metabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of sarcinapterin metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of sarcinapterin metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of sarcinapterin metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of sarcinapterin metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of sarcinapterin metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of sarcinapterin metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of sarcinapterin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0045864 ! positive regulation of pteridine metabolic process
is_a: GO:0045937 ! positive regulation of phosphate metabolic process
is_a: GO:1900968 ! regulation of sarcinapterin metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900867 ! sarcinapterin metabolic process
relationship: positively_regulates GO:1900867 ! sarcinapterin metabolic process
created_by: tt
creation_date: 2012-06-14T03:58:43Z

[Term]
id: GO:1900971
name: regulation of sarcinapterin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sarcinapterin biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of sarcinapterin anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of sarcinapterin biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of sarcinapterin formation" EXACT [GOC:TermGenie]
synonym: "regulation of sarcinapterin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:1900968 ! regulation of sarcinapterin metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900868 ! sarcinapterin biosynthetic process
relationship: regulates GO:1900868 ! sarcinapterin biosynthetic process
created_by: tt
creation_date: 2012-06-14T03:59:44Z

[Term]
id: GO:1900972
name: negative regulation of sarcinapterin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sarcinapterin biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of sarcinapterin anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of sarcinapterin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of sarcinapterin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of sarcinapterin formation" EXACT [GOC:TermGenie]
synonym: "down regulation of sarcinapterin synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of sarcinapterin anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of sarcinapterin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of sarcinapterin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of sarcinapterin formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of sarcinapterin synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of sarcinapterin anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of sarcinapterin biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of sarcinapterin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of sarcinapterin formation" EXACT [GOC:TermGenie]
synonym: "downregulation of sarcinapterin synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of sarcinapterin anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of sarcinapterin biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of sarcinapterin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of sarcinapterin formation" EXACT [GOC:TermGenie]
synonym: "inhibition of sarcinapterin synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of sarcinapterin anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of sarcinapterin biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of sarcinapterin formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of sarcinapterin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:1900969 ! negative regulation of sarcinapterin metabolic process
is_a: GO:1900971 ! regulation of sarcinapterin biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900868 ! sarcinapterin biosynthetic process
relationship: negatively_regulates GO:1900868 ! sarcinapterin biosynthetic process
created_by: tt
creation_date: 2012-06-14T04:00:06Z

[Term]
id: GO:1900973
name: positive regulation of sarcinapterin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sarcinapterin biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of sarcinapterin anabolism" EXACT [GOC:TermGenie]
synonym: "activation of sarcinapterin biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of sarcinapterin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of sarcinapterin formation" EXACT [GOC:TermGenie]
synonym: "activation of sarcinapterin synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of sarcinapterin anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of sarcinapterin biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of sarcinapterin formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of sarcinapterin synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of sarcinapterin anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of sarcinapterin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of sarcinapterin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of sarcinapterin formation" EXACT [GOC:TermGenie]
synonym: "up regulation of sarcinapterin synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of sarcinapterin anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of sarcinapterin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of sarcinapterin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of sarcinapterin formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of sarcinapterin synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of sarcinapterin anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of sarcinapterin biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of sarcinapterin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of sarcinapterin formation" EXACT [GOC:TermGenie]
synonym: "upregulation of sarcinapterin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:1900970 ! positive regulation of sarcinapterin metabolic process
is_a: GO:1900971 ! regulation of sarcinapterin biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900868 ! sarcinapterin biosynthetic process
relationship: positively_regulates GO:1900868 ! sarcinapterin biosynthetic process
created_by: tt
creation_date: 2012-06-14T04:00:14Z

[Term]
id: GO:1900974
name: regulation of tatiopterin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tatiopterin biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of tatiopterin anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of tatiopterin biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of tatiopterin formation" EXACT [GOC:TermGenie]
synonym: "regulation of tatiopterin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:1900977 ! regulation of tatiopterin metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900870 ! tatiopterin biosynthetic process
relationship: regulates GO:1900870 ! tatiopterin biosynthetic process
created_by: tt
creation_date: 2012-06-14T04:01:42Z

[Term]
id: GO:1900975
name: negative regulation of tatiopterin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tatiopterin biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of tatiopterin anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of tatiopterin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of tatiopterin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of tatiopterin formation" EXACT [GOC:TermGenie]
synonym: "down regulation of tatiopterin synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of tatiopterin anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of tatiopterin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of tatiopterin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of tatiopterin formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of tatiopterin synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of tatiopterin anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of tatiopterin biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of tatiopterin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of tatiopterin formation" EXACT [GOC:TermGenie]
synonym: "downregulation of tatiopterin synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of tatiopterin anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of tatiopterin biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of tatiopterin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of tatiopterin formation" EXACT [GOC:TermGenie]
synonym: "inhibition of tatiopterin synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of tatiopterin anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of tatiopterin biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of tatiopterin formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of tatiopterin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:1900974 ! regulation of tatiopterin biosynthetic process
is_a: GO:1900978 ! negative regulation of tatiopterin metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900870 ! tatiopterin biosynthetic process
relationship: negatively_regulates GO:1900870 ! tatiopterin biosynthetic process
created_by: tt
creation_date: 2012-06-14T04:02:06Z

[Term]
id: GO:1900976
name: positive regulation of tatiopterin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tatiopterin biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of tatiopterin anabolism" EXACT [GOC:TermGenie]
synonym: "activation of tatiopterin biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of tatiopterin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of tatiopterin formation" EXACT [GOC:TermGenie]
synonym: "activation of tatiopterin synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of tatiopterin anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of tatiopterin biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of tatiopterin formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of tatiopterin synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of tatiopterin anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of tatiopterin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of tatiopterin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of tatiopterin formation" EXACT [GOC:TermGenie]
synonym: "up regulation of tatiopterin synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of tatiopterin anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of tatiopterin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of tatiopterin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of tatiopterin formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of tatiopterin synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of tatiopterin anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of tatiopterin biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of tatiopterin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of tatiopterin formation" EXACT [GOC:TermGenie]
synonym: "upregulation of tatiopterin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:1900974 ! regulation of tatiopterin biosynthetic process
is_a: GO:1900979 ! positive regulation of tatiopterin metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900870 ! tatiopterin biosynthetic process
relationship: positively_regulates GO:1900870 ! tatiopterin biosynthetic process
created_by: tt
creation_date: 2012-06-14T04:02:14Z

[Term]
id: GO:1900977
name: regulation of tatiopterin metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tatiopterin metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of tatiopterin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
is_a: GO:0051174 ! regulation of phosphorus metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900869 ! tatiopterin metabolic process
relationship: regulates GO:1900869 ! tatiopterin metabolic process
created_by: tt
creation_date: 2012-06-14T04:03:06Z

[Term]
id: GO:1900978
name: negative regulation of tatiopterin metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tatiopterin metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of tatiopterin metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of tatiopterin metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of tatiopterin metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of tatiopterin metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of tatiopterin metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of tatiopterin metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of tatiopterin metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of tatiopterin metabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of tatiopterin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0010563 ! negative regulation of phosphorus metabolic process
is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process
is_a: GO:1900977 ! regulation of tatiopterin metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900869 ! tatiopterin metabolic process
relationship: negatively_regulates GO:1900869 ! tatiopterin metabolic process
created_by: tt
creation_date: 2012-06-14T04:03:29Z

[Term]
id: GO:1900979
name: positive regulation of tatiopterin metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tatiopterin metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of tatiopterin metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of tatiopterin metabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of tatiopterin metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of tatiopterin metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of tatiopterin metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of tatiopterin metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of tatiopterin metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of tatiopterin metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of tatiopterin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0010562 ! positive regulation of phosphorus metabolic process
is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process
is_a: GO:1900977 ! regulation of tatiopterin metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900869 ! tatiopterin metabolic process
relationship: positively_regulates GO:1900869 ! tatiopterin metabolic process
created_by: tt
creation_date: 2012-06-14T04:03:37Z

[Term]
id: GO:1900980
name: regulation of phenazine biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phenazine biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of acridizine biosynthesis" RELATED [GOC:TermGenie]
synonym: "regulation of acridizine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "regulation of azophenylene biosynthesis" RELATED [GOC:TermGenie]
synonym: "regulation of azophenylene biosynthetic process" RELATED [GOC:TermGenie]
synonym: "regulation of dibenzo-p-diazine biosynthesis" RELATED [GOC:TermGenie]
synonym: "regulation of dibenzo-p-diazine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "regulation of dibenzopyrazine biosynthesis" RELATED [GOC:TermGenie]
synonym: "regulation of dibenzopyrazine biosynthetic process" RELATED [GOC:TermGenie]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002047 ! phenazine biosynthetic process
relationship: regulates GO:0002047 ! phenazine biosynthetic process
created_by: tt
creation_date: 2012-06-14T04:04:39Z

[Term]
id: GO:1900981
name: negative regulation of phenazine biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of phenazine biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of acridizine biosynthesis" RELATED [GOC:TermGenie]
synonym: "down regulation of acridizine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "down regulation of azophenylene biosynthesis" RELATED [GOC:TermGenie]
synonym: "down regulation of azophenylene biosynthetic process" RELATED [GOC:TermGenie]
synonym: "down regulation of dibenzo-p-diazine biosynthesis" RELATED [GOC:TermGenie]
synonym: "down regulation of dibenzo-p-diazine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "down regulation of dibenzopyrazine biosynthesis" RELATED [GOC:TermGenie]
synonym: "down regulation of dibenzopyrazine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "down regulation of phenazine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of acridizine biosynthesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of acridizine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "down-regulation of azophenylene biosynthesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of azophenylene biosynthetic process" RELATED [GOC:TermGenie]
synonym: "down-regulation of dibenzo-p-diazine biosynthesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of dibenzo-p-diazine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "down-regulation of dibenzopyrazine biosynthesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of dibenzopyrazine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "down-regulation of phenazine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of acridizine biosynthesis" RELATED [GOC:TermGenie]
synonym: "downregulation of acridizine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "downregulation of azophenylene biosynthesis" RELATED [GOC:TermGenie]
synonym: "downregulation of azophenylene biosynthetic process" RELATED [GOC:TermGenie]
synonym: "downregulation of dibenzo-p-diazine biosynthesis" RELATED [GOC:TermGenie]
synonym: "downregulation of dibenzo-p-diazine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "downregulation of dibenzopyrazine biosynthesis" RELATED [GOC:TermGenie]
synonym: "downregulation of dibenzopyrazine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "downregulation of phenazine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "inhibition of acridizine biosynthesis" RELATED [GOC:TermGenie]
synonym: "inhibition of acridizine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "inhibition of azophenylene biosynthesis" RELATED [GOC:TermGenie]
synonym: "inhibition of azophenylene biosynthetic process" RELATED [GOC:TermGenie]
synonym: "inhibition of dibenzo-p-diazine biosynthesis" RELATED [GOC:TermGenie]
synonym: "inhibition of dibenzo-p-diazine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "inhibition of dibenzopyrazine biosynthesis" RELATED [GOC:TermGenie]
synonym: "inhibition of dibenzopyrazine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "inhibition of phenazine biosynthetic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of acridizine biosynthesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of acridizine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "negative regulation of azophenylene biosynthesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of azophenylene biosynthetic process" RELATED [GOC:TermGenie]
synonym: "negative regulation of dibenzo-p-diazine biosynthesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of dibenzo-p-diazine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "negative regulation of dibenzopyrazine biosynthesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of dibenzopyrazine biosynthetic process" RELATED [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process
is_a: GO:1900980 ! regulation of phenazine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002047 ! phenazine biosynthetic process
relationship: negatively_regulates GO:0002047 ! phenazine biosynthetic process
created_by: tt
creation_date: 2012-06-14T04:05:03Z

[Term]
id: GO:1900982
name: positive regulation of phenazine biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phenazine biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of acridizine biosynthesis" RELATED [GOC:TermGenie]
synonym: "activation of acridizine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "activation of azophenylene biosynthesis" RELATED [GOC:TermGenie]
synonym: "activation of azophenylene biosynthetic process" RELATED [GOC:TermGenie]
synonym: "activation of dibenzo-p-diazine biosynthesis" RELATED [GOC:TermGenie]
synonym: "activation of dibenzo-p-diazine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "activation of dibenzopyrazine biosynthesis" RELATED [GOC:TermGenie]
synonym: "activation of dibenzopyrazine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "activation of phenazine biosynthetic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of acridizine biosynthesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of acridizine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "positive regulation of azophenylene biosynthesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of azophenylene biosynthetic process" RELATED [GOC:TermGenie]
synonym: "positive regulation of dibenzo-p-diazine biosynthesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of dibenzo-p-diazine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "positive regulation of dibenzopyrazine biosynthesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of dibenzopyrazine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "up regulation of acridizine biosynthesis" RELATED [GOC:TermGenie]
synonym: "up regulation of acridizine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "up regulation of azophenylene biosynthesis" RELATED [GOC:TermGenie]
synonym: "up regulation of azophenylene biosynthetic process" RELATED [GOC:TermGenie]
synonym: "up regulation of dibenzo-p-diazine biosynthesis" RELATED [GOC:TermGenie]
synonym: "up regulation of dibenzo-p-diazine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "up regulation of dibenzopyrazine biosynthesis" RELATED [GOC:TermGenie]
synonym: "up regulation of dibenzopyrazine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "up regulation of phenazine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of acridizine biosynthesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of acridizine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "up-regulation of azophenylene biosynthesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of azophenylene biosynthetic process" RELATED [GOC:TermGenie]
synonym: "up-regulation of dibenzo-p-diazine biosynthesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of dibenzo-p-diazine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "up-regulation of dibenzopyrazine biosynthesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of dibenzopyrazine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "up-regulation of phenazine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of acridizine biosynthesis" RELATED [GOC:TermGenie]
synonym: "upregulation of acridizine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "upregulation of azophenylene biosynthesis" RELATED [GOC:TermGenie]
synonym: "upregulation of azophenylene biosynthetic process" RELATED [GOC:TermGenie]
synonym: "upregulation of dibenzo-p-diazine biosynthesis" RELATED [GOC:TermGenie]
synonym: "upregulation of dibenzo-p-diazine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "upregulation of dibenzopyrazine biosynthesis" RELATED [GOC:TermGenie]
synonym: "upregulation of dibenzopyrazine biosynthetic process" RELATED [GOC:TermGenie]
synonym: "upregulation of phenazine biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process
is_a: GO:1900980 ! regulation of phenazine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002047 ! phenazine biosynthetic process
relationship: positively_regulates GO:0002047 ! phenazine biosynthetic process
created_by: tt
creation_date: 2012-06-14T04:05:10Z

[Term]
id: GO:1900983
name: vindoline metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving vindoline." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5292, UniPathway:UPA00365]
synonym: "vindoline metabolism" EXACT [GOC:TermGenie]
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0046447 ! terpenoid indole alkaloid metabolic process
is_a: GO:0097164 ! ammonium ion metabolic process
is_a: GO:1900619 ! acetate ester metabolic process
is_a: GO:1901376 ! organic heteropentacyclic compound metabolic process
is_a: GO:1902644 ! tertiary alcohol metabolic process
created_by: yaf
creation_date: 2012-06-14T09:16:29Z

[Term]
id: GO:1900984
name: vindoline catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of vindoline." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5292, UniPathway:UPA00365]
synonym: "vindoline breakdown" EXACT [GOC:TermGenie]
synonym: "vindoline catabolism" EXACT [GOC:TermGenie]
synonym: "vindoline degradation" EXACT [GOC:TermGenie]
is_a: GO:0009822 ! alkaloid catabolic process
is_a: GO:0046164 ! alcohol catabolic process
is_a: GO:1900983 ! vindoline metabolic process
is_a: GO:1901377 ! organic heteropentacyclic compound catabolic process
created_by: yaf
creation_date: 2012-06-14T09:16:56Z

[Term]
id: GO:1900985
name: vindoline biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of vindoline." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5292, UniPathway:UPA00365]
synonym: "vindoline anabolism" EXACT [GOC:TermGenie]
synonym: "vindoline biosynthesis" EXACT [GOC:TermGenie]
synonym: "vindoline formation" EXACT [GOC:TermGenie]
synonym: "vindoline synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009709 ! terpenoid indole alkaloid biosynthetic process
is_a: GO:1900620 ! acetate ester biosynthetic process
is_a: GO:1900983 ! vindoline metabolic process
is_a: GO:1901378 ! organic heteropentacyclic compound biosynthetic process
is_a: GO:1902645 ! tertiary alcohol biosynthetic process
created_by: yaf
creation_date: 2012-06-14T09:17:03Z

[Term]
id: GO:1900986
name: ajmaline metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ajmaline." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00310]
synonym: "ajmaline metabolism" EXACT [GOC:TermGenie]
is_a: GO:0046447 ! terpenoid indole alkaloid metabolic process
is_a: GO:0097164 ! ammonium ion metabolic process
created_by: yaf
creation_date: 2012-06-14T09:47:02Z

[Term]
id: GO:1900987
name: ajmaline catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ajmaline." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00310]
synonym: "ajmaline breakdown" EXACT [GOC:TermGenie]
synonym: "ajmaline catabolism" EXACT [GOC:TermGenie]
synonym: "ajmaline degradation" EXACT [GOC:TermGenie]
is_a: GO:0009822 ! alkaloid catabolic process
is_a: GO:1900986 ! ajmaline metabolic process
created_by: yaf
creation_date: 2012-06-14T09:47:26Z

[Term]
id: GO:1900988
name: ajmaline biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ajmaline." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00310]
synonym: "ajmaline anabolism" EXACT [GOC:TermGenie]
synonym: "ajmaline biosynthesis" EXACT [GOC:TermGenie]
synonym: "ajmaline formation" EXACT [GOC:TermGenie]
synonym: "ajmaline synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009709 ! terpenoid indole alkaloid biosynthetic process
is_a: GO:1900986 ! ajmaline metabolic process
created_by: yaf
creation_date: 2012-06-14T09:47:33Z

[Term]
id: GO:1900989
name: scopolamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving scopolamine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00725]
synonym: "scopolamine metabolism" EXACT [GOC:TermGenie]
is_a: GO:0046448 ! tropane alkaloid metabolic process
is_a: GO:0097164 ! ammonium ion metabolic process
is_a: GO:0097176 ! epoxide metabolic process
created_by: yaf
creation_date: 2012-06-14T09:47:38Z

[Term]
id: GO:1900990
name: scopolamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of scopolamine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00725]
synonym: "scopolamine breakdown" EXACT [GOC:TermGenie]
synonym: "scopolamine catabolism" EXACT [GOC:TermGenie]
synonym: "scopolamine degradation" EXACT [GOC:TermGenie]
is_a: GO:0009822 ! alkaloid catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1900989 ! scopolamine metabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901502 ! ether catabolic process
created_by: yaf
creation_date: 2012-06-14T09:48:00Z

[Term]
id: GO:1900991
name: scopolamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of scopolamine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00725]
synonym: "scopolamine anabolism" EXACT [GOC:TermGenie]
synonym: "scopolamine biosynthesis" EXACT [GOC:TermGenie]
synonym: "scopolamine formation" EXACT [GOC:TermGenie]
synonym: "scopolamine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009710 ! tropane alkaloid biosynthetic process
is_a: GO:1900989 ! scopolamine metabolic process
is_a: GO:1901503 ! ether biosynthetic process
created_by: yaf
creation_date: 2012-06-14T09:48:07Z

[Term]
id: GO:1900992
name: (-)-secologanin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (-)-secologanin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00328]
synonym: "(-)-secologanin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006081 ! cellular aldehyde metabolic process
is_a: GO:0016098 ! monoterpenoid metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901804 ! beta-glucoside metabolic process
created_by: yaf
creation_date: 2012-06-14T09:51:17Z

[Term]
id: GO:1900993
name: (-)-secologanin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of (-)-secologanin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00328]
synonym: "(-)-secologanin breakdown" EXACT [GOC:TermGenie]
synonym: "(-)-secologanin catabolism" EXACT [GOC:TermGenie]
synonym: "(-)-secologanin degradation" EXACT [GOC:TermGenie]
is_a: GO:0016100 ! monoterpenoid catabolic process
is_a: GO:0046185 ! aldehyde catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1900992 ! (-)-secologanin metabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901805 ! beta-glucoside catabolic process
created_by: yaf
creation_date: 2012-06-14T09:51:39Z

[Term]
id: GO:1900994
name: (-)-secologanin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (-)-secologanin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00328]
synonym: "(-)-secologanin anabolism" EXACT [GOC:TermGenie]
synonym: "(-)-secologanin biosynthesis" EXACT [GOC:TermGenie]
synonym: "(-)-secologanin formation" EXACT [GOC:TermGenie]
synonym: "(-)-secologanin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0016099 ! monoterpenoid biosynthetic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0046184 ! aldehyde biosynthetic process
is_a: GO:1900992 ! (-)-secologanin metabolic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901806 ! beta-glucoside biosynthetic process
created_by: yaf
creation_date: 2012-06-14T09:51:46Z

[Term]
id: GO:1900995
name: ubiquinone-6 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with ubiquinone-6. Ubiquinone-6 is a ubiquinone compound having a (2E,6E,10E,14E,18E)-3,7,11,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaen-1-yl substituent at position 2." [CHEBI:52971, GOC:al, GOC:TermGenie]
is_a: GO:0048039 ! ubiquinone binding
created_by: bf
creation_date: 2012-06-14T02:49:15Z

[Term]
id: GO:1900996
name: benzene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of benzene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00272]
synonym: "benzene breakdown" EXACT [GOC:TermGenie]
synonym: "benzene catabolism" EXACT [GOC:TermGenie]
synonym: "benzene degradation" EXACT [GOC:TermGenie]
is_a: GO:0018910 ! benzene metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
created_by: yaf
creation_date: 2012-06-14T02:53:38Z

[Term]
id: GO:1900997
name: benzene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of benzene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00272]
synonym: "benzene anabolism" EXACT [GOC:TermGenie]
synonym: "benzene biosynthesis" EXACT [GOC:TermGenie]
synonym: "benzene formation" EXACT [GOC:TermGenie]
synonym: "benzene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0018910 ! benzene metabolic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
created_by: yaf
creation_date: 2012-06-14T02:54:01Z

[Term]
id: GO:1900998
name: nitrobenzene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of nitrobenzene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00923]
synonym: "nitrobenzene breakdown" EXACT [GOC:TermGenie]
synonym: "nitrobenzene catabolism" EXACT [GOC:TermGenie]
synonym: "nitrobenzene degradation" EXACT [GOC:TermGenie]
is_a: GO:0018916 ! nitrobenzene metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
created_by: yaf
creation_date: 2012-06-14T02:54:09Z

[Term]
id: GO:1900999
name: nitrobenzene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nitrobenzene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00923]
synonym: "nitrobenzene anabolism" EXACT [GOC:TermGenie]
synonym: "nitrobenzene biosynthesis" EXACT [GOC:TermGenie]
synonym: "nitrobenzene formation" EXACT [GOC:TermGenie]
synonym: "nitrobenzene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0018916 ! nitrobenzene metabolic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
created_by: yaf
creation_date: 2012-06-14T02:54:32Z

[Term]
id: GO:1901000
name: regulation of response to salt stress
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to salt stress." [GOC:TermGenie, PMID:22627139]
synonym: "regulation of response to ionic osmotic stress" EXACT [GOC:TermGenie]
synonym: "regulation of salinity response" EXACT [GOC:TermGenie]
is_a: GO:0047484 ! regulation of response to osmotic stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009651 ! response to salt stress
relationship: regulates GO:0009651 ! response to salt stress
created_by: dhl
creation_date: 2012-06-14T05:41:19Z

[Term]
id: GO:1901001
name: negative regulation of response to salt stress
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to salt stress." [GOC:TermGenie, PMID:22627139]
synonym: "down regulation of response to ionic osmotic stress" EXACT [GOC:TermGenie]
synonym: "down regulation of response to salt stress" EXACT [GOC:TermGenie]
synonym: "down regulation of salinity response" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to ionic osmotic stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to salt stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of salinity response" EXACT [GOC:TermGenie]
synonym: "downregulation of response to ionic osmotic stress" EXACT [GOC:TermGenie]
synonym: "downregulation of response to salt stress" EXACT [GOC:TermGenie]
synonym: "downregulation of salinity response" EXACT [GOC:TermGenie]
synonym: "inhibition of response to ionic osmotic stress" EXACT [GOC:TermGenie]
synonym: "inhibition of response to salt stress" NARROW [GOC:TermGenie]
synonym: "inhibition of salinity response" EXACT [GOC:TermGenie]
synonym: "negative regulation of response to ionic osmotic stress" EXACT [GOC:TermGenie]
synonym: "negative regulation of salinity response" EXACT [GOC:TermGenie]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1901000 ! regulation of response to salt stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009651 ! response to salt stress
relationship: negatively_regulates GO:0009651 ! response to salt stress
created_by: dhl
creation_date: 2012-06-14T05:41:43Z

[Term]
id: GO:1901002
name: positive regulation of response to salt stress
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to salt stress." [GOC:TermGenie, PMID:22627139]
synonym: "activation of response to ionic osmotic stress" EXACT [GOC:TermGenie]
synonym: "activation of response to salt stress" NARROW [GOC:TermGenie]
synonym: "activation of salinity response" EXACT [GOC:TermGenie]
synonym: "positive regulation of response to ionic osmotic stress" EXACT [GOC:TermGenie]
synonym: "positive regulation of salinity response" EXACT [GOC:TermGenie]
synonym: "up regulation of response to ionic osmotic stress" EXACT [GOC:TermGenie]
synonym: "up regulation of response to salt stress" EXACT [GOC:TermGenie]
synonym: "up regulation of salinity response" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to ionic osmotic stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to salt stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of salinity response" EXACT [GOC:TermGenie]
synonym: "upregulation of response to ionic osmotic stress" EXACT [GOC:TermGenie]
synonym: "upregulation of response to salt stress" EXACT [GOC:TermGenie]
synonym: "upregulation of salinity response" EXACT [GOC:TermGenie]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1901000 ! regulation of response to salt stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009651 ! response to salt stress
relationship: positively_regulates GO:0009651 ! response to salt stress
created_by: dhl
creation_date: 2012-06-14T05:41:50Z

[Term]
id: GO:1901003
name: negative regulation of fermentation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of fermentation." [GOC:TermGenie]
synonym: "down regulation of fermentation" EXACT [GOC:TermGenie]
synonym: "down-regulation of fermentation" EXACT [GOC:TermGenie]
synonym: "downregulation of fermentation" EXACT [GOC:TermGenie]
synonym: "inhibition of fermentation" NARROW [GOC:TermGenie]
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0043465 ! regulation of fermentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006113 ! fermentation
relationship: negatively_regulates GO:0006113 ! fermentation
created_by: al
creation_date: 2012-06-15T08:21:31Z

[Term]
id: GO:1901004
name: ubiquinone-6 metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ubiquinone-6. Ubiquinone-6 is a ubiquinone compound having a (2E,6E,10E,14E,18E)-3,7,11,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaen-1-yl substituent at position 2." [GOC:al, GOC:TermGenie, PMID:1409592]
synonym: "coenzyme Q6 metabolic process" EXACT [CHEBI:52971]
synonym: "coenzyme Q6 metabolism" EXACT [CHEBI:52971]
synonym: "ubiquinone-6 metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006743 ! ubiquinone metabolic process
created_by: bf
creation_date: 2012-06-15T09:59:28Z

[Term]
id: GO:1901005
name: ubiquinone-6 catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ubiquinone-6." [GOC:TermGenie]
synonym: "ubiquinone-6 breakdown" EXACT [GOC:TermGenie]
synonym: "ubiquinone-6 catabolism" EXACT [GOC:TermGenie]
synonym: "ubiquinone-6 degradation" EXACT [GOC:TermGenie]
is_a: GO:0032322 ! ubiquinone catabolic process
is_a: GO:1901004 ! ubiquinone-6 metabolic process
created_by: bf
creation_date: 2012-06-15T09:59:51Z

[Term]
id: GO:1901006
name: ubiquinone-6 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ubiquinone-6." [GOC:TermGenie]
synonym: "ubiquinone-6 anabolism" EXACT [GOC:TermGenie]
synonym: "ubiquinone-6 biosynthesis" EXACT [GOC:TermGenie]
synonym: "ubiquinone-6 formation" EXACT [GOC:TermGenie]
synonym: "ubiquinone-6 synthesis" EXACT [GOC:TermGenie]
is_a: GO:0006744 ! ubiquinone biosynthetic process
is_a: GO:1901004 ! ubiquinone-6 metabolic process
created_by: bf
creation_date: 2012-06-15T09:59:58Z

[Term]
id: GO:1901007
name: (S)-scoulerine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (S)-scoulerine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00319]
synonym: "(S)-scoulerine metabolism" EXACT [GOC:TermGenie]
is_a: GO:0033076 ! isoquinoline alkaloid metabolic process
created_by: yaf
creation_date: 2012-06-15T10:45:48Z

[Term]
id: GO:1901008
name: (S)-scoulerine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of (S)-scoulerine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00319]
synonym: "(S)-scoulerine breakdown" EXACT [GOC:TermGenie]
synonym: "(S)-scoulerine catabolism" EXACT [GOC:TermGenie]
synonym: "(S)-scoulerine degradation" EXACT [GOC:TermGenie]
is_a: GO:0071274 ! isoquinoline alkaloid catabolic process
is_a: GO:1901007 ! (S)-scoulerine metabolic process
created_by: yaf
creation_date: 2012-06-15T10:46:10Z

[Term]
id: GO:1901009
name: (S)-scoulerine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (S)-scoulerine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00319]
synonym: "(S)-scoulerine anabolism" EXACT [GOC:TermGenie]
synonym: "(S)-scoulerine biosynthesis" EXACT [GOC:TermGenie]
synonym: "(S)-scoulerine formation" EXACT [GOC:TermGenie]
synonym: "(S)-scoulerine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0033075 ! isoquinoline alkaloid biosynthetic process
is_a: GO:1901007 ! (S)-scoulerine metabolic process
created_by: yaf
creation_date: 2012-06-15T10:46:17Z

[Term]
id: GO:1901010
name: (S)-reticuline metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (S)-reticuline." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00306]
synonym: "(S)-reticuline metabolism" EXACT [GOC:TermGenie]
is_a: GO:0046445 ! benzyl isoquinoline alkaloid metabolic process
is_a: GO:0097164 ! ammonium ion metabolic process
created_by: yaf
creation_date: 2012-06-15T10:46:22Z

[Term]
id: GO:1901011
name: (S)-reticuline catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of (S)-reticuline." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00306]
synonym: "(S)-reticuline breakdown" EXACT [GOC:TermGenie]
synonym: "(S)-reticuline catabolism" EXACT [GOC:TermGenie]
synonym: "(S)-reticuline degradation" EXACT [GOC:TermGenie]
is_a: GO:0071274 ! isoquinoline alkaloid catabolic process
is_a: GO:1901010 ! (S)-reticuline metabolic process
created_by: yaf
creation_date: 2012-06-15T10:46:45Z

[Term]
id: GO:1901012
name: (S)-reticuline biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (S)-reticuline." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00306]
synonym: "(S)-reticuline anabolism" EXACT [GOC:TermGenie]
synonym: "(S)-reticuline biosynthesis" EXACT [GOC:TermGenie]
synonym: "(S)-reticuline formation" EXACT [GOC:TermGenie]
synonym: "(S)-reticuline synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009708 ! benzyl isoquinoline alkaloid biosynthetic process
is_a: GO:1901010 ! (S)-reticuline metabolic process
created_by: yaf
creation_date: 2012-06-15T10:46:52Z

[Term]
id: GO:1901013
name: 3alpha(S)-strictosidine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 3alpha(S)-strictosidine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00311]
synonym: "3alpha(S)-strictosidine metabolism" EXACT [GOC:TermGenie]
is_a: GO:0035834 ! indole alkaloid metabolic process
is_a: GO:0097164 ! ammonium ion metabolic process
is_a: GO:1901804 ! beta-glucoside metabolic process
created_by: yaf
creation_date: 2012-06-15T10:46:57Z

[Term]
id: GO:1901014
name: 3alpha(S)-strictosidine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 3alpha(S)-strictosidine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00311]
synonym: "3alpha(S)-strictosidine breakdown" EXACT [GOC:TermGenie]
synonym: "3alpha(S)-strictosidine catabolism" EXACT [GOC:TermGenie]
synonym: "3alpha(S)-strictosidine degradation" EXACT [GOC:TermGenie]
is_a: GO:0009822 ! alkaloid catabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:1901013 ! 3alpha(S)-strictosidine metabolic process
is_a: GO:1901805 ! beta-glucoside catabolic process
created_by: yaf
creation_date: 2012-06-15T10:47:19Z

[Term]
id: GO:1901015
name: 3alpha(S)-strictosidine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 3alpha(S)-strictosidine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00311]
synonym: "3alpha(S)-strictosidine anabolism" EXACT [GOC:TermGenie]
synonym: "3alpha(S)-strictosidine biosynthesis" EXACT [GOC:TermGenie]
synonym: "3alpha(S)-strictosidine formation" EXACT [GOC:TermGenie]
synonym: "3alpha(S)-strictosidine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0035835 ! indole alkaloid biosynthetic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:1901013 ! 3alpha(S)-strictosidine metabolic process
is_a: GO:1901806 ! beta-glucoside biosynthetic process
created_by: yaf
creation_date: 2012-06-15T10:47:26Z

[Term]
id: GO:1901016
name: regulation of potassium ion transmembrane transporter activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of potassium ion transmembrane transporter activity." [GOC:BHF, GOC:TermGenie]
synonym: "regulation of potassium transporter activity" EXACT [GOC:TermGenie]
is_a: GO:0032412 ! regulation of ion transmembrane transporter activity
is_a: GO:1901379 ! regulation of potassium ion transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0015079 ! potassium ion transmembrane transporter activity
relationship: regulates GO:0015079 ! potassium ion transmembrane transporter activity
created_by: rl
creation_date: 2012-06-15T01:13:49Z

[Term]
id: GO:1901017
name: negative regulation of potassium ion transmembrane transporter activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion transmembrane transporter activity." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of potassium ion transmembrane transporter activity" EXACT [GOC:TermGenie]
synonym: "down regulation of potassium transporter activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of potassium ion transmembrane transporter activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of potassium transporter activity" EXACT [GOC:TermGenie]
synonym: "downregulation of potassium ion transmembrane transporter activity" EXACT [GOC:TermGenie]
synonym: "downregulation of potassium transporter activity" EXACT [GOC:TermGenie]
synonym: "inhibition of potassium ion transmembrane transporter activity" NARROW [GOC:TermGenie]
synonym: "inhibition of potassium transporter activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of potassium transporter activity" EXACT [GOC:TermGenie]
is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity
is_a: GO:1901016 ! regulation of potassium ion transmembrane transporter activity
is_a: GO:1901380 ! negative regulation of potassium ion transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0015079 ! potassium ion transmembrane transporter activity
relationship: negatively_regulates GO:0015079 ! potassium ion transmembrane transporter activity
created_by: rl
creation_date: 2012-06-15T01:14:10Z

[Term]
id: GO:1901018
name: positive regulation of potassium ion transmembrane transporter activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of potassium ion transmembrane transporter activity." [GOC:BHF, GOC:TermGenie]
synonym: "activation of potassium ion transmembrane transporter activity" NARROW [GOC:TermGenie]
synonym: "activation of potassium transporter activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of potassium transporter activity" EXACT [GOC:TermGenie]
synonym: "up regulation of potassium ion transmembrane transporter activity" EXACT [GOC:TermGenie]
synonym: "up regulation of potassium transporter activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of potassium ion transmembrane transporter activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of potassium transporter activity" EXACT [GOC:TermGenie]
synonym: "upregulation of potassium ion transmembrane transporter activity" EXACT [GOC:TermGenie]
synonym: "upregulation of potassium transporter activity" EXACT [GOC:TermGenie]
is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity
is_a: GO:1901016 ! regulation of potassium ion transmembrane transporter activity
is_a: GO:1901381 ! positive regulation of potassium ion transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0015079 ! potassium ion transmembrane transporter activity
relationship: positively_regulates GO:0015079 ! potassium ion transmembrane transporter activity
created_by: rl
creation_date: 2012-06-15T01:14:18Z

[Term]
id: GO:1901019
name: regulation of calcium ion transmembrane transporter activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of calcium ion transmembrane transporter activity." [GOC:BHF, GOC:TermGenie]
is_a: GO:0032412 ! regulation of ion transmembrane transporter activity
is_a: GO:1903169 ! regulation of calcium ion transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0015085 ! calcium ion transmembrane transporter activity
relationship: regulates GO:0015085 ! calcium ion transmembrane transporter activity
created_by: rl
creation_date: 2012-06-15T07:54:12Z

[Term]
id: GO:1901020
name: negative regulation of calcium ion transmembrane transporter activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion transmembrane transporter activity." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of calcium ion transmembrane transporter activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of calcium ion transmembrane transporter activity" EXACT [GOC:TermGenie]
synonym: "downregulation of calcium ion transmembrane transporter activity" EXACT [GOC:TermGenie]
synonym: "inhibition of calcium ion transmembrane transporter activity" NARROW [GOC:TermGenie]
is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity
is_a: GO:1901019 ! regulation of calcium ion transmembrane transporter activity
is_a: GO:1903170 ! negative regulation of calcium ion transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0015085 ! calcium ion transmembrane transporter activity
relationship: negatively_regulates GO:0015085 ! calcium ion transmembrane transporter activity
created_by: rl
creation_date: 2012-06-15T07:54:32Z

[Term]
id: GO:1901021
name: positive regulation of calcium ion transmembrane transporter activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of calcium ion transmembrane transporter activity." [GOC:BHF, GOC:TermGenie]
synonym: "activation of calcium ion transmembrane transporter activity" NARROW [GOC:TermGenie]
synonym: "up regulation of calcium ion transmembrane transporter activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of calcium ion transmembrane transporter activity" EXACT [GOC:TermGenie]
synonym: "upregulation of calcium ion transmembrane transporter activity" EXACT [GOC:TermGenie]
is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity
is_a: GO:1901019 ! regulation of calcium ion transmembrane transporter activity
is_a: GO:1904427 ! positive regulation of calcium ion transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0015085 ! calcium ion transmembrane transporter activity
relationship: positively_regulates GO:0015085 ! calcium ion transmembrane transporter activity
created_by: rl
creation_date: 2012-06-15T07:54:40Z

[Term]
id: GO:1901022
name: 4-hydroxyphenylacetate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 4-hydroxyphenylacetate." [GOC:TermGenie, GOC:yaf, MetaCyc:RXN-8505, UniPathway:UPA00208]
synonym: "4-hydroxyphenylacetate metabolism" EXACT [GOC:TermGenie]
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
created_by: yaf
creation_date: 2012-06-18T02:31:37Z

[Term]
id: GO:1901023
name: 4-hydroxyphenylacetate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 4-hydroxyphenylacetate." [GOC:TermGenie, GOC:yaf, MetaCyc:RXN-8505, UniPathway:UPA00208]
synonym: "4-hydroxyphenylacetate breakdown" EXACT [GOC:TermGenie]
synonym: "4-hydroxyphenylacetate catabolism" EXACT [GOC:TermGenie]
synonym: "4-hydroxyphenylacetate degradation" EXACT [GOC:TermGenie]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:1901022 ! 4-hydroxyphenylacetate metabolic process
created_by: yaf
creation_date: 2012-06-18T02:31:58Z

[Term]
id: GO:1901024
name: 4-hydroxyphenylacetate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 4-hydroxyphenylacetate." [GOC:TermGenie, GOC:yaf, MetaCyc:RXN-8505, UniPathway:UPA00208]
synonym: "4-hydroxyphenylacetate anabolism" EXACT [GOC:TermGenie]
synonym: "4-hydroxyphenylacetate biosynthesis" EXACT [GOC:TermGenie]
synonym: "4-hydroxyphenylacetate formation" EXACT [GOC:TermGenie]
synonym: "4-hydroxyphenylacetate synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:1901022 ! 4-hydroxyphenylacetate metabolic process
created_by: yaf
creation_date: 2012-06-18T02:32:06Z

[Term]
id: GO:1901025
name: ripoptosome assembly involved in extrinsic apoptotic signaling pathway
namespace: biological_process
def: "The aggregation, arrangement and bonding together of ripoptosome components leading to apoptosis via the extrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis, GOC:TermGenie, PMID:22274400]
is_a: GO:0097343 ! ripoptosome assembly
intersection_of: GO:0097343 ! ripoptosome assembly
intersection_of: part_of GO:0097191 ! extrinsic apoptotic signaling pathway
relationship: part_of GO:0097191 ! extrinsic apoptotic signaling pathway
created_by: pr
creation_date: 2012-06-19T08:49:33Z

[Term]
id: GO:1901026
name: ripoptosome assembly involved in necroptotic process
namespace: biological_process
def: "The aggregation, arrangement and bonding together of ripoptosome components leading to a necroptotic process." [GOC:mtg_apoptosis, GOC:TermGenie, PMID:22274400]
synonym: "ripoptosome assembly involved in necroptosis" NARROW []
is_a: GO:0097343 ! ripoptosome assembly
intersection_of: GO:0097343 ! ripoptosome assembly
intersection_of: part_of GO:0070266 ! necroptotic process
relationship: part_of GO:0070266 ! necroptotic process
created_by: pr
creation_date: 2012-06-19T08:54:28Z

[Term]
id: GO:1901027
name: dextrin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dextrin." [GOC:TermGenie]
synonym: "dextrin breakdown" EXACT [GOC:TermGenie]
synonym: "dextrin catabolism" EXACT [GOC:TermGenie]
synonym: "dextrin degradation" EXACT [GOC:TermGenie]
is_a: GO:0009251 ! glucan catabolic process
created_by: al
creation_date: 2012-06-19T03:12:19Z

[Term]
id: GO:1901028
name: regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:TermGenie]
synonym: "regulation of mitochondrial outer membrane permeabilization" BROAD []
synonym: "regulation of MOMP" EXACT [GOC:TermGenie]
is_a: GO:0010821 ! regulation of mitochondrion organization
is_a: GO:0032386 ! regulation of intracellular transport
is_a: GO:0046902 ! regulation of mitochondrial membrane permeability
is_a: GO:2001233 ! regulation of apoptotic signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097345 ! mitochondrial outer membrane permeabilization
relationship: regulates GO:0097345 ! mitochondrial outer membrane permeabilization
created_by: pr
creation_date: 2012-06-20T09:19:16Z

[Term]
id: GO:1901029
name: negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:TermGenie]
synonym: "down regulation of mitochondrial outer membrane permeabilization" EXACT [GOC:TermGenie]
synonym: "down regulation of MOMP" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitochondrial outer membrane permeabilization" EXACT [GOC:TermGenie]
synonym: "down-regulation of MOMP" EXACT [GOC:TermGenie]
synonym: "downregulation of mitochondrial outer membrane permeabilization" EXACT [GOC:TermGenie]
synonym: "downregulation of MOMP" EXACT [GOC:TermGenie]
synonym: "inhibition of mitochondrial outer membrane permeabilization" NARROW [GOC:TermGenie]
synonym: "inhibition of MOMP" NARROW [GOC:TermGenie]
synonym: "negative regulation of mitochondrial outer membrane permeabilization" BROAD []
synonym: "negative regulation of MOMP" EXACT [GOC:TermGenie]
is_a: GO:0010823 ! negative regulation of mitochondrion organization
is_a: GO:0032387 ! negative regulation of intracellular transport
is_a: GO:1901028 ! regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
is_a: GO:2001234 ! negative regulation of apoptotic signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097345 ! mitochondrial outer membrane permeabilization
relationship: negatively_regulates GO:0097345 ! mitochondrial outer membrane permeabilization
created_by: pr
creation_date: 2012-06-20T09:19:39Z

[Term]
id: GO:1901030
name: positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:TermGenie]
comment: Caspase 8 may be annotated to this term when it is shown to stimulate MOMP by cleaving the BH3-only protein BID.
synonym: "activation of mitochondrial outer membrane permeabilization" NARROW [GOC:TermGenie]
synonym: "activation of MOMP" NARROW [GOC:TermGenie]
synonym: "positive regulation of mitochondrial outer membrane permeabilization" BROAD []
synonym: "positive regulation of MOMP" EXACT [GOC:TermGenie]
synonym: "up regulation of mitochondrial outer membrane permeabilization" EXACT [GOC:TermGenie]
synonym: "up regulation of MOMP" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitochondrial outer membrane permeabilization" EXACT [GOC:TermGenie]
synonym: "up-regulation of MOMP" EXACT [GOC:TermGenie]
synonym: "upregulation of mitochondrial outer membrane permeabilization" EXACT [GOC:TermGenie]
synonym: "upregulation of MOMP" EXACT [GOC:TermGenie]
is_a: GO:0010822 ! positive regulation of mitochondrion organization
is_a: GO:0032388 ! positive regulation of intracellular transport
is_a: GO:1901028 ! regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
is_a: GO:2001235 ! positive regulation of apoptotic signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097345 ! mitochondrial outer membrane permeabilization
relationship: positively_regulates GO:0097345 ! mitochondrial outer membrane permeabilization
created_by: pr
creation_date: 2012-06-20T09:19:46Z

[Term]
id: GO:1901031
name: regulation of response to reactive oxygen species
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to reactive oxygen species." [GOC:kmv, GOC:TermGenie]
synonym: "regulation of response to active oxygen species" EXACT [GOC:TermGenie]
synonym: "regulation of response to AOS" EXACT [GOC:TermGenie]
synonym: "regulation of response to reactive oxidative species" EXACT [GOC:TermGenie]
synonym: "regulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie]
synonym: "regulation of response to ROI" EXACT [GOC:TermGenie]
synonym: "regulation of response to ROS" EXACT [GOC:TermGenie]
is_a: GO:1902882 ! regulation of response to oxidative stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000302 ! response to reactive oxygen species
relationship: regulates GO:0000302 ! response to reactive oxygen species
created_by: kmv
creation_date: 2012-06-20T07:47:06Z

[Term]
id: GO:1901032
name: negative regulation of response to reactive oxygen species
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to reactive oxygen species." [GOC:kmv, GOC:TermGenie]
synonym: "down regulation of response to active oxygen species" EXACT [GOC:TermGenie]
synonym: "down regulation of response to AOS" EXACT [GOC:TermGenie]
synonym: "down regulation of response to reactive oxidative species" EXACT [GOC:TermGenie]
synonym: "down regulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie]
synonym: "down regulation of response to reactive oxygen species" EXACT [GOC:TermGenie]
synonym: "down regulation of response to ROI" EXACT [GOC:TermGenie]
synonym: "down regulation of response to ROS" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to active oxygen species" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to AOS" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to reactive oxidative species" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to reactive oxygen species" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to ROI" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to ROS" EXACT [GOC:TermGenie]
synonym: "downregulation of response to active oxygen species" EXACT [GOC:TermGenie]
synonym: "downregulation of response to AOS" EXACT [GOC:TermGenie]
synonym: "downregulation of response to reactive oxidative species" EXACT [GOC:TermGenie]
synonym: "downregulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie]
synonym: "downregulation of response to reactive oxygen species" EXACT [GOC:TermGenie]
synonym: "downregulation of response to ROI" EXACT [GOC:TermGenie]
synonym: "downregulation of response to ROS" EXACT [GOC:TermGenie]
synonym: "inhibition of response to active oxygen species" EXACT [GOC:TermGenie]
synonym: "inhibition of response to AOS" EXACT [GOC:TermGenie]
synonym: "inhibition of response to reactive oxidative species" EXACT [GOC:TermGenie]
synonym: "inhibition of response to reactive oxygen intermediate" EXACT [GOC:TermGenie]
synonym: "inhibition of response to reactive oxygen species" NARROW [GOC:TermGenie]
synonym: "inhibition of response to ROI" EXACT [GOC:TermGenie]
synonym: "inhibition of response to ROS" EXACT [GOC:TermGenie]
synonym: "negative regulation of response to active oxygen species" EXACT [GOC:TermGenie]
synonym: "negative regulation of response to AOS" EXACT [GOC:TermGenie]
synonym: "negative regulation of response to reactive oxidative species" EXACT [GOC:TermGenie]
synonym: "negative regulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie]
synonym: "negative regulation of response to ROI" EXACT [GOC:TermGenie]
synonym: "negative regulation of response to ROS" EXACT [GOC:TermGenie]
is_a: GO:1901031 ! regulation of response to reactive oxygen species
is_a: GO:1902883 ! negative regulation of response to oxidative stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000302 ! response to reactive oxygen species
relationship: negatively_regulates GO:0000302 ! response to reactive oxygen species
created_by: kmv
creation_date: 2012-06-20T07:47:28Z

[Term]
id: GO:1901033
name: positive regulation of response to reactive oxygen species
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to reactive oxygen species." [GOC:kmv, GOC:TermGenie]
synonym: "activation of response to active oxygen species" EXACT [GOC:TermGenie]
synonym: "activation of response to AOS" EXACT [GOC:TermGenie]
synonym: "activation of response to reactive oxidative species" EXACT [GOC:TermGenie]
synonym: "activation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie]
synonym: "activation of response to reactive oxygen species" NARROW [GOC:TermGenie]
synonym: "activation of response to ROI" EXACT [GOC:TermGenie]
synonym: "activation of response to ROS" EXACT [GOC:TermGenie]
synonym: "positive regulation of response to active oxygen species" EXACT [GOC:TermGenie]
synonym: "positive regulation of response to AOS" EXACT [GOC:TermGenie]
synonym: "positive regulation of response to reactive oxidative species" EXACT [GOC:TermGenie]
synonym: "positive regulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie]
synonym: "positive regulation of response to ROI" EXACT [GOC:TermGenie]
synonym: "positive regulation of response to ROS" EXACT [GOC:TermGenie]
synonym: "up regulation of response to active oxygen species" EXACT [GOC:TermGenie]
synonym: "up regulation of response to AOS" EXACT [GOC:TermGenie]
synonym: "up regulation of response to reactive oxidative species" EXACT [GOC:TermGenie]
synonym: "up regulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie]
synonym: "up regulation of response to reactive oxygen species" EXACT [GOC:TermGenie]
synonym: "up regulation of response to ROI" EXACT [GOC:TermGenie]
synonym: "up regulation of response to ROS" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to active oxygen species" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to AOS" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to reactive oxidative species" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to reactive oxygen species" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to ROI" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to ROS" EXACT [GOC:TermGenie]
synonym: "upregulation of response to active oxygen species" EXACT [GOC:TermGenie]
synonym: "upregulation of response to AOS" EXACT [GOC:TermGenie]
synonym: "upregulation of response to reactive oxidative species" EXACT [GOC:TermGenie]
synonym: "upregulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie]
synonym: "upregulation of response to reactive oxygen species" EXACT [GOC:TermGenie]
synonym: "upregulation of response to ROI" EXACT [GOC:TermGenie]
synonym: "upregulation of response to ROS" EXACT [GOC:TermGenie]
is_a: GO:1901031 ! regulation of response to reactive oxygen species
is_a: GO:1902884 ! positive regulation of response to oxidative stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000302 ! response to reactive oxygen species
relationship: positively_regulates GO:0000302 ! response to reactive oxygen species
created_by: kmv
creation_date: 2012-06-20T07:47:35Z

[Term]
id: GO:1901034
name: regulation of L-glutamine import
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of L-glutamine import." [GOC:TermGenie]
synonym: "regulation of L-glutamine uptake" EXACT [GOC:TermGenie]
is_a: GO:0010958 ! regulation of amino acid import
is_a: GO:2000485 ! regulation of glutamine transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0036229 ! L-glutamine import
relationship: regulates GO:0036229 ! L-glutamine import
created_by: al
creation_date: 2012-06-21T07:31:27Z

[Term]
id: GO:1901035
name: negative regulation of L-glutamine import
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of L-glutamine import." [GOC:TermGenie]
synonym: "down regulation of L-glutamine import" EXACT [GOC:TermGenie]
synonym: "down regulation of L-glutamine uptake" EXACT [GOC:TermGenie]
synonym: "down-regulation of L-glutamine import" EXACT [GOC:TermGenie]
synonym: "down-regulation of L-glutamine uptake" EXACT [GOC:TermGenie]
synonym: "downregulation of L-glutamine import" EXACT [GOC:TermGenie]
synonym: "downregulation of L-glutamine uptake" EXACT [GOC:TermGenie]
synonym: "inhibition of L-glutamine import" NARROW [GOC:TermGenie]
synonym: "inhibition of L-glutamine uptake" EXACT [GOC:TermGenie]
synonym: "negative regulation of L-glutamine uptake" EXACT [GOC:TermGenie]
is_a: GO:1901034 ! regulation of L-glutamine import
is_a: GO:2000486 ! negative regulation of glutamine transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0036229 ! L-glutamine import
relationship: negatively_regulates GO:0036229 ! L-glutamine import
created_by: al
creation_date: 2012-06-21T07:31:48Z

[Term]
id: GO:1901036
name: positive regulation of L-glutamine import
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of L-glutamine import." [GOC:TermGenie]
synonym: "activation of L-glutamine import" NARROW [GOC:TermGenie]
synonym: "activation of L-glutamine uptake" EXACT [GOC:TermGenie]
synonym: "positive regulation of L-glutamine uptake" EXACT [GOC:TermGenie]
synonym: "up regulation of L-glutamine import" EXACT [GOC:TermGenie]
synonym: "up regulation of L-glutamine uptake" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-glutamine import" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-glutamine uptake" EXACT [GOC:TermGenie]
synonym: "upregulation of L-glutamine import" EXACT [GOC:TermGenie]
synonym: "upregulation of L-glutamine uptake" EXACT [GOC:TermGenie]
is_a: GO:1901034 ! regulation of L-glutamine import
is_a: GO:2000487 ! positive regulation of glutamine transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0036229 ! L-glutamine import
relationship: positively_regulates GO:0036229 ! L-glutamine import
created_by: al
creation_date: 2012-06-21T07:31:56Z

[Term]
id: GO:1901037
name: obsolete regulation of transcription from RNA polymerase II promoter during M/G1 transition of mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that regulates transcription such that the target genes are transcribed during the M/G1 transition of the mitotic cell cycle." [GOC:mah, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:12411492]
comment: This term was made obsolete because it does not refer to a real biological process.
synonym: "global transcription regulation from Pol II promoter during M/G1 transition of mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "regulation of gene-specific transcription from RNA polymerase II promoter during M/G1 transition of mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "regulation of global transcription from Pol II promoter during M/G1 transition of mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "regulation of transcription during M/G1 transition of mitotic cell cycle" BROAD []
synonym: "regulation of transcription from Pol II promoter during M/G1 transition of mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter during M/G1 transition of mitotic cell cycle" EXACT []
synonym: "regulation of transcription from RNA polymerase II promoter involved in M/G1 transition of mitotic cell cycle" RELATED []
is_obsolete: true
created_by: pr
creation_date: 2012-06-21T10:09:51Z

[Term]
id: GO:1901038
name: cyanidin 3-O-glucoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cyanidin 3-O-beta-D-glucoside." [GOC:TermGenie, PMID:21899608]
synonym: "cyanidin 3-O-beta-D-glucoside metabolic process" EXACT []
synonym: "cyanidin 3-O-beta-D-glucoside metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009812 ! flavonoid metabolic process
is_a: GO:1901804 ! beta-glucoside metabolic process
created_by: tb
creation_date: 2012-06-22T12:16:26Z

[Term]
id: GO:1901039
name: regulation of peptide antigen transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of peptide antigen transport." [GOC:bf, GOC:TermGenie]
is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen
is_a: GO:0090087 ! regulation of peptide transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0046968 ! peptide antigen transport
relationship: regulates GO:0046968 ! peptide antigen transport
created_by: bf
creation_date: 2012-06-22T04:07:56Z

[Term]
id: GO:1901040
name: negative regulation of peptide antigen transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of peptide antigen transport." [GOC:bf, GOC:TermGenie, PMID:16691491]
synonym: "down regulation of peptide antigen transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of peptide antigen transport" EXACT [GOC:TermGenie]
synonym: "downregulation of peptide antigen transport" EXACT [GOC:TermGenie]
synonym: "inhibition of peptide antigen transport" NARROW [GOC:TermGenie]
is_a: GO:0002584 ! negative regulation of antigen processing and presentation of peptide antigen
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:1901039 ! regulation of peptide antigen transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0046968 ! peptide antigen transport
relationship: negatively_regulates GO:0046968 ! peptide antigen transport
created_by: bf
creation_date: 2012-06-22T04:08:18Z

[Term]
id: GO:1901041
name: positive regulation of peptide antigen transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of peptide antigen transport." [GOC:bf, GOC:TermGenie]
synonym: "activation of peptide antigen transport" NARROW [GOC:TermGenie]
synonym: "up regulation of peptide antigen transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of peptide antigen transport" EXACT [GOC:TermGenie]
synonym: "upregulation of peptide antigen transport" EXACT [GOC:TermGenie]
is_a: GO:0002585 ! positive regulation of antigen processing and presentation of peptide antigen
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:1901039 ! regulation of peptide antigen transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0046968 ! peptide antigen transport
relationship: positively_regulates GO:0046968 ! peptide antigen transport
created_by: bf
creation_date: 2012-06-22T04:08:26Z

[Term]
id: GO:1901042
name: positive regulation of L-arginine import
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of L-arginine import." [GOC:TermGenie]
synonym: "activation of L-arginine import" NARROW [GOC:TermGenie]
synonym: "activation of L-arginine uptake" EXACT [GOC:TermGenie]
synonym: "positive regulation of L-arginine uptake" EXACT [GOC:TermGenie]
synonym: "up regulation of L-arginine import" EXACT [GOC:TermGenie]
synonym: "up regulation of L-arginine uptake" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-arginine import" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-arginine uptake" EXACT [GOC:TermGenie]
synonym: "upregulation of L-arginine import" EXACT [GOC:TermGenie]
synonym: "upregulation of L-arginine uptake" EXACT [GOC:TermGenie]
is_a: GO:0010963 ! regulation of L-arginine import
is_a: GO:0051957 ! positive regulation of amino acid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043091 ! L-arginine import
relationship: positively_regulates GO:0043091 ! L-arginine import
created_by: al
creation_date: 2012-06-25T12:27:24Z

[Term]
id: GO:1901043
name: obsolete protein polyubiquitination involved in cellular response to misfolded protein
namespace: biological_process
def: "OBSOLETE. Any protein polyubiquitination that is involved in cellular response to misfolded protein." [GOC:al, GOC:TermGenie, PMID:21324894]
comment: This term was made obsolete because it was added in error and a more specific term was created.
synonym: "polyubiquitin of cellular response to misfolded protein" RELATED [GOC:TermGenie]
synonym: "protein polyubiquitination involved in cellular response to misfolded protein" EXACT []
synonym: "protein polyubiquitination of cellular response to misfolded protein" EXACT [GOC:TermGenie]
synonym: "protein polyubiquitinylation of cellular response to misfolded protein" EXACT [GOC:TermGenie]
synonym: "protein polyubiquitylation of cellular response to misfolded protein" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:1901044
created_by: al
creation_date: 2012-06-26T09:40:45Z

[Term]
id: GO:1901044
name: protein polyubiquitination involved in nucleus-associated proteasomal ubiquitin-dependent protein catabolic process
namespace: biological_process
def: "Any protein polyubiquitination that is involved in nucleus-associated proteasomal ubiquitin-dependent protein catabolic process." [GOC:al, GOC:TermGenie, PMID:21324894]
is_a: GO:0000209 ! protein polyubiquitination
is_a: GO:0042787 ! protein ubiquitination involved in ubiquitin-dependent protein catabolic process
intersection_of: GO:0000209 ! protein polyubiquitination
intersection_of: part_of GO:0071630 ! nucleus-associated proteasomal ubiquitin-dependent protein catabolic process
relationship: part_of GO:0071630 ! nucleus-associated proteasomal ubiquitin-dependent protein catabolic process
created_by: al
creation_date: 2012-06-26T10:59:04Z

[Term]
id: GO:1901045
name: negative regulation of oviposition
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of oviposition." [GOC:kmv, GOC:TermGenie]
synonym: "down regulation of egg laying" BROAD [GOC:TermGenie]
synonym: "down regulation of egg-laying" BROAD [GOC:TermGenie]
synonym: "down regulation of oviposition" EXACT [GOC:TermGenie]
synonym: "down-regulation of egg laying" BROAD [GOC:TermGenie]
synonym: "down-regulation of egg-laying" BROAD [GOC:TermGenie]
synonym: "down-regulation of oviposition" EXACT [GOC:TermGenie]
synonym: "downregulation of egg laying" BROAD [GOC:TermGenie]
synonym: "downregulation of egg-laying" BROAD [GOC:TermGenie]
synonym: "downregulation of oviposition" EXACT [GOC:TermGenie]
synonym: "inhibition of egg laying" BROAD [GOC:TermGenie]
synonym: "inhibition of egg-laying" BROAD [GOC:TermGenie]
synonym: "inhibition of oviposition" NARROW [GOC:TermGenie]
synonym: "negative regulation of egg laying" BROAD [GOC:TermGenie]
synonym: "negative regulation of egg-laying" BROAD [GOC:TermGenie]
is_a: GO:0043901 ! negative regulation of multi-organism process
is_a: GO:0046662 ! regulation of oviposition
is_a: GO:0048521 ! negative regulation of behavior
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000242 ! negative regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0018991 ! oviposition
relationship: negatively_regulates GO:0018991 ! oviposition
created_by: kmv
creation_date: 2012-06-27T06:19:58Z

[Term]
id: GO:1901046
name: positive regulation of oviposition
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of oviposition." [GOC:kmv, GOC:TermGenie]
synonym: "activation of egg laying" BROAD [GOC:TermGenie]
synonym: "activation of egg-laying" BROAD [GOC:TermGenie]
synonym: "activation of oviposition" NARROW [GOC:TermGenie]
synonym: "positive regulation of egg laying" BROAD [GOC:TermGenie]
synonym: "positive regulation of egg-laying" BROAD [GOC:TermGenie]
synonym: "up regulation of egg laying" BROAD [GOC:TermGenie]
synonym: "up regulation of egg-laying" BROAD [GOC:TermGenie]
synonym: "up regulation of oviposition" EXACT [GOC:TermGenie]
synonym: "up-regulation of egg laying" BROAD [GOC:TermGenie]
synonym: "up-regulation of egg-laying" BROAD [GOC:TermGenie]
synonym: "up-regulation of oviposition" EXACT [GOC:TermGenie]
synonym: "upregulation of egg laying" BROAD [GOC:TermGenie]
synonym: "upregulation of egg-laying" BROAD [GOC:TermGenie]
synonym: "upregulation of oviposition" EXACT [GOC:TermGenie]
is_a: GO:0043902 ! positive regulation of multi-organism process
is_a: GO:0046662 ! regulation of oviposition
is_a: GO:0048520 ! positive regulation of behavior
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000243 ! positive regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0018991 ! oviposition
relationship: positively_regulates GO:0018991 ! oviposition
created_by: kmv
creation_date: 2012-06-27T06:20:20Z

[Term]
id: GO:1901047
name: insulin receptor signaling pathway involved in determination of adult lifespan
namespace: biological_process
def: "The series of molecular signals generated as a consequence of the insulin receptor binding to insulin that controls viability and duration in the adult phase of the life-cycle." [GOC:kmv, GOC:TermGenie, PMID:9360933]
synonym: "daf-2 receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie]
synonym: "insulin receptor signaling pathway of determination of adult lifespan" EXACT [GOC:TermGenie]
synonym: "insulin receptor signalling pathway of determination of adult lifespan" EXACT [GOC:TermGenie]
is_a: GO:0008286 ! insulin receptor signaling pathway
intersection_of: GO:0008286 ! insulin receptor signaling pathway
intersection_of: part_of GO:0008340 ! determination of adult lifespan
relationship: part_of GO:0008340 ! determination of adult lifespan
created_by: kmv
creation_date: 2012-06-27T06:55:18Z

[Term]
id: GO:1901048
name: transforming growth factor beta receptor signaling pathway involved in regulation of multicellular organism growth
namespace: biological_process
def: "A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription, that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size." [GOC:kmv, GOC:TermGenie, PMID:9847239]
synonym: "TGF-beta receptor signaling pathway of regulation of body growth" EXACT [GOC:TermGenie]
synonym: "TGF-beta receptor signaling pathway of regulation of body size" EXACT [GOC:TermGenie]
synonym: "TGF-beta receptor signaling pathway of regulation of multicellular organism growth" EXACT [GOC:TermGenie]
synonym: "TGF-beta receptor signalling pathway of regulation of body growth" EXACT [GOC:TermGenie]
synonym: "TGF-beta receptor signalling pathway of regulation of body size" EXACT [GOC:TermGenie]
synonym: "TGF-beta receptor signalling pathway of regulation of multicellular organism growth" EXACT [GOC:TermGenie]
synonym: "TGFbeta receptor signaling pathway of regulation of body growth" EXACT [GOC:TermGenie]
synonym: "TGFbeta receptor signaling pathway of regulation of body size" EXACT [GOC:TermGenie]
synonym: "TGFbeta receptor signaling pathway of regulation of multicellular organism growth" EXACT [GOC:TermGenie]
synonym: "TGFbeta receptor signalling pathway of regulation of body growth" EXACT [GOC:TermGenie]
synonym: "TGFbeta receptor signalling pathway of regulation of body size" EXACT [GOC:TermGenie]
synonym: "TGFbeta receptor signalling pathway of regulation of multicellular organism growth" EXACT [GOC:TermGenie]
synonym: "transforming growth factor beta receptor signaling pathway of regulation of body growth" EXACT [GOC:TermGenie]
synonym: "transforming growth factor beta receptor signaling pathway of regulation of body size" EXACT [GOC:TermGenie]
synonym: "transforming growth factor beta receptor signaling pathway of regulation of multicellular organism growth" EXACT [GOC:TermGenie]
synonym: "transforming growth factor beta receptor signalling pathway of regulation of body growth" EXACT [GOC:TermGenie]
synonym: "transforming growth factor beta receptor signalling pathway of regulation of body size" EXACT [GOC:TermGenie]
synonym: "transforming growth factor beta receptor signalling pathway of regulation of multicellular organism growth" EXACT [GOC:TermGenie]
is_a: GO:0007179 ! transforming growth factor beta receptor signaling pathway
intersection_of: GO:0007179 ! transforming growth factor beta receptor signaling pathway
intersection_of: part_of GO:0040014 ! regulation of multicellular organism growth
relationship: part_of GO:0040014 ! regulation of multicellular organism growth
created_by: kmv
creation_date: 2012-06-27T07:37:22Z

[Term]
id: GO:1901049
name: atropine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving atropine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00303]
synonym: "atropine metabolism" EXACT [GOC:TermGenie]
is_a: GO:0046448 ! tropane alkaloid metabolic process
is_a: GO:0097164 ! ammonium ion metabolic process
created_by: yaf
creation_date: 2012-06-28T04:51:25Z

[Term]
id: GO:1901050
name: atropine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of atropine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00303]
synonym: "atropine breakdown" EXACT [GOC:TermGenie]
synonym: "atropine catabolism" EXACT [GOC:TermGenie]
synonym: "atropine degradation" EXACT [GOC:TermGenie]
is_a: GO:0009822 ! alkaloid catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1901049 ! atropine metabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
created_by: yaf
creation_date: 2012-06-28T04:51:51Z

[Term]
id: GO:1901051
name: atropine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of atropine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00303]
synonym: "atropine anabolism" EXACT [GOC:TermGenie]
synonym: "atropine biosynthesis" EXACT [GOC:TermGenie]
synonym: "atropine formation" EXACT [GOC:TermGenie]
synonym: "atropine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009710 ! tropane alkaloid biosynthetic process
is_a: GO:1901049 ! atropine metabolic process
created_by: yaf
creation_date: 2012-06-28T04:51:59Z

[Term]
id: GO:1901052
name: sarcosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sarcosine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00292]
synonym: "sarcosine metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006575 ! cellular modified amino acid metabolic process
is_a: GO:1901605 ! alpha-amino acid metabolic process
created_by: yaf
creation_date: 2012-06-28T04:52:04Z

[Term]
id: GO:1901053
name: sarcosine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of sarcosine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00292]
synonym: "sarcosine breakdown" EXACT [GOC:TermGenie]
synonym: "sarcosine catabolism" EXACT [GOC:TermGenie]
synonym: "sarcosine degradation" EXACT [GOC:TermGenie]
is_a: GO:0042219 ! cellular modified amino acid catabolic process
is_a: GO:1901052 ! sarcosine metabolic process
is_a: GO:1901606 ! alpha-amino acid catabolic process
created_by: yaf
creation_date: 2012-06-28T04:52:29Z

[Term]
id: GO:1901054
name: sarcosine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sarcosine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00292]
synonym: "sarcosine anabolism" EXACT [GOC:TermGenie]
synonym: "sarcosine biosynthesis" EXACT [GOC:TermGenie]
synonym: "sarcosine formation" EXACT [GOC:TermGenie]
synonym: "sarcosine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0042398 ! cellular modified amino acid biosynthetic process
is_a: GO:1901052 ! sarcosine metabolic process
is_a: GO:1901607 ! alpha-amino acid biosynthetic process
created_by: yaf
creation_date: 2012-06-28T04:52:37Z

[Term]
id: GO:1901055
name: trimethylenediamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving trimethylenediamine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00010]
synonym: "trimethylenediamine metabolism" EXACT [GOC:TermGenie]
is_a: GO:0097164 ! ammonium ion metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process
created_by: yaf
creation_date: 2012-06-28T04:52:42Z

[Term]
id: GO:1901056
name: trimethylenediamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of trimethylenediamine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00010]
synonym: "trimethylenediamine breakdown" EXACT [GOC:TermGenie]
synonym: "trimethylenediamine catabolism" EXACT [GOC:TermGenie]
synonym: "trimethylenediamine degradation" EXACT [GOC:TermGenie]
is_a: GO:1901055 ! trimethylenediamine metabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process
created_by: yaf
creation_date: 2012-06-28T04:53:06Z

[Term]
id: GO:1901057
name: trimethylenediamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of trimethylenediamine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00010]
synonym: "trimethylenediamine anabolism" EXACT [GOC:TermGenie]
synonym: "trimethylenediamine biosynthesis" EXACT [GOC:TermGenie]
synonym: "trimethylenediamine formation" EXACT [GOC:TermGenie]
synonym: "trimethylenediamine synthesis" EXACT [GOC:TermGenie]
is_a: GO:1901055 ! trimethylenediamine metabolic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process
created_by: yaf
creation_date: 2012-06-28T04:53:14Z

[Term]
id: GO:1901058
name: p-hydroxyphenyl lignin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving p-hydroxyphenyl lignin." [GOC:mengo_curators, GOC:TermGenie]
synonym: "H-lignin metabolic process" EXACT [GOC:mengo_curators]
synonym: "p-hydroxyphenyl lignin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009808 ! lignin metabolic process
created_by: tt
creation_date: 2012-06-29T12:31:57Z

[Term]
id: GO:1901059
name: p-hydroxyphenyl lignin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of p-hydroxyphenyl lignin." [GOC:mengo_curators, GOC:TermGenie]
synonym: "H-lignin catabolic process" EXACT [GOC:mengo_curators]
synonym: "p-hydroxyphenyl lignin breakdown" EXACT [GOC:TermGenie]
synonym: "p-hydroxyphenyl lignin catabolism" EXACT [GOC:TermGenie]
synonym: "p-hydroxyphenyl lignin degradation" EXACT [GOC:TermGenie]
is_a: GO:0046274 ! lignin catabolic process
is_a: GO:1901058 ! p-hydroxyphenyl lignin metabolic process
created_by: tt
creation_date: 2012-06-29T12:32:17Z

[Term]
id: GO:1901060
name: p-hydroxyphenyl lignin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of p-hydroxyphenyl lignin." [GOC:mengo_curators, GOC:TermGenie]
synonym: "H-lignin biosynthetic process" EXACT [GOC:mengo_curators]
synonym: "p-hydroxyphenyl lignin anabolism" EXACT [GOC:TermGenie]
synonym: "p-hydroxyphenyl lignin biosynthesis" EXACT [GOC:TermGenie]
synonym: "p-hydroxyphenyl lignin formation" EXACT [GOC:TermGenie]
synonym: "p-hydroxyphenyl lignin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009809 ! lignin biosynthetic process
is_a: GO:1901058 ! p-hydroxyphenyl lignin metabolic process
created_by: tt
creation_date: 2012-06-29T02:42:36Z

[Term]
id: GO:1901061
name: guaiacyl lignin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving guaiacyl lignin." [GOC:mengo_curators, GOC:TermGenie]
synonym: "G-lignin metabolic process" EXACT [GOC:mengo_curators]
synonym: "guaiacyl lignin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009808 ! lignin metabolic process
created_by: tt
creation_date: 2012-06-29T02:46:39Z

[Term]
id: GO:1901062
name: guaiacyl lignin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of guaiacyl lignin." [GOC:mengo_curators, GOC:TermGenie]
synonym: "G-lignin catabolic process" EXACT [GOC:mengo_curators]
synonym: "guaiacyl lignin breakdown" EXACT [GOC:TermGenie]
synonym: "guaiacyl lignin catabolism" EXACT [GOC:TermGenie]
synonym: "guaiacyl lignin degradation" EXACT [GOC:TermGenie]
is_a: GO:0046274 ! lignin catabolic process
is_a: GO:1901061 ! guaiacyl lignin metabolic process
created_by: tt
creation_date: 2012-06-29T02:47:03Z

[Term]
id: GO:1901063
name: guaiacyl lignin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of guaiacyl lignin." [GOC:mengo_curators, GOC:TermGenie]
synonym: "G-lignin biosynthetic process" EXACT [GOC:mengo_curators]
synonym: "guaiacyl lignin anabolism" EXACT [GOC:TermGenie]
synonym: "guaiacyl lignin biosynthesis" EXACT [GOC:TermGenie]
synonym: "guaiacyl lignin formation" EXACT [GOC:TermGenie]
synonym: "guaiacyl lignin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009809 ! lignin biosynthetic process
is_a: GO:1901061 ! guaiacyl lignin metabolic process
created_by: tt
creation_date: 2012-06-29T03:29:53Z

[Term]
id: GO:1901064
name: syringal lignin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving syringal lignin." [GOC:mengo_curators, GOC:TermGenie]
synonym: "S-lignin metabolic process" EXACT [GOC:mengo_curators]
synonym: "syringal lignin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009808 ! lignin metabolic process
created_by: tt
creation_date: 2012-06-29T03:48:11Z

[Term]
id: GO:1901065
name: syringal lignin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of syringal lignin." [GOC:mengo_curators, GOC:TermGenie]
synonym: "S-lignin catabolic process" EXACT [GOC:mengo_curators]
synonym: "syringal lignin breakdown" EXACT [GOC:TermGenie]
synonym: "syringal lignin catabolism" EXACT [GOC:TermGenie]
synonym: "syringal lignin degradation" EXACT [GOC:TermGenie]
is_a: GO:0046274 ! lignin catabolic process
is_a: GO:1901064 ! syringal lignin metabolic process
created_by: tt
creation_date: 2012-06-29T03:48:33Z

[Term]
id: GO:1901066
name: syringal lignin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of syringal lignin." [GOC:mengo_curators, GOC:TermGenie]
synonym: "S-lignin biosynthetic process" EXACT [GOC:mengo_curators]
synonym: "syringal lignin anabolism" EXACT [GOC:TermGenie]
synonym: "syringal lignin biosynthesis" EXACT [GOC:TermGenie]
synonym: "syringal lignin formation" EXACT [GOC:TermGenie]
synonym: "syringal lignin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009809 ! lignin biosynthetic process
is_a: GO:1901064 ! syringal lignin metabolic process
created_by: tt
creation_date: 2012-06-29T03:48:41Z

[Term]
id: GO:1901067
name: ferulate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ferulate." [GOC:mengo_curators, GOC:TermGenie]
synonym: "ferulate breakdown" EXACT [GOC:TermGenie]
synonym: "ferulate catabolism" EXACT [GOC:TermGenie]
synonym: "ferulate degradation" EXACT [GOC:TermGenie]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0033494 ! ferulate metabolic process
is_a: GO:0046271 ! phenylpropanoid catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:1901502 ! ether catabolic process
created_by: tt
creation_date: 2012-06-29T08:06:37Z

[Term]
id: GO:1901068
name: guanosine-containing compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving guanosine-containing compounds (guanosines)." [GOC:TermGenie]
synonym: "guanosine-containing compound metabolism" EXACT [GOC:bf]
synonym: "guanosines metabolic process" EXACT [CHEBI:24458]
synonym: "guanosines metabolism" EXACT [GOC:TermGenie]
is_a: GO:0046128 ! purine ribonucleoside metabolic process
created_by: bf
creation_date: 2012-07-02T01:51:37Z

[Term]
id: GO:1901069
name: guanosine-containing compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of guanosine-containing compounds (guanosines)." [GOC:TermGenie]
synonym: "guanosine-containing compound breakdown" EXACT [GOC:bf]
synonym: "guanosine-containing compound catabolism" EXACT [GOC:bf]
synonym: "guanosine-containing compound degradation" EXACT [GOC:bf]
synonym: "guanosines breakdown" EXACT [GOC:TermGenie]
synonym: "guanosines catabolic process" EXACT [CHEBI:24458]
synonym: "guanosines catabolism" EXACT [GOC:TermGenie]
synonym: "guanosines degradation" EXACT [GOC:TermGenie]
is_a: GO:0046130 ! purine ribonucleoside catabolic process
is_a: GO:1901068 ! guanosine-containing compound metabolic process
created_by: bf
creation_date: 2012-07-02T01:52:00Z

[Term]
id: GO:1901070
name: guanosine-containing compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of guanosine-containing compounds (guanosines)." [GOC:TermGenie]
synonym: "guanosine-containing compound anabolism" EXACT [GOC:bf]
synonym: "guanosine-containing compound biosynthesis" EXACT [GOC:bf]
synonym: "guanosine-containing compound formation" EXACT [GOC:bf]
synonym: "guanosine-containing compound synthesis" EXACT [GOC:bf]
synonym: "guanosines anabolism" EXACT [GOC:TermGenie]
synonym: "guanosines biosynthesis" EXACT [GOC:TermGenie]
synonym: "guanosines biosynthetic process" EXACT [CHEBI:24458]
synonym: "guanosines formation" EXACT [GOC:TermGenie]
synonym: "guanosines synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046129 ! purine ribonucleoside biosynthetic process
is_a: GO:1901068 ! guanosine-containing compound metabolic process
created_by: bf
creation_date: 2012-07-02T01:52:09Z

[Term]
id: GO:1901071
name: glucosamine-containing compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glucosamine-containing compounds (glucosamines)." [GOC:TermGenie]
synonym: "glucosamine-containing compound metabolism" EXACT [GOC:bf]
synonym: "glucosamines metabolic process" EXACT [CHEBI:24271]
synonym: "glucosamines metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006040 ! amino sugar metabolic process
created_by: bf
creation_date: 2012-07-02T03:18:04Z

[Term]
id: GO:1901072
name: glucosamine-containing compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glucosamine-containing compounds (glucosamines)." [GOC:TermGenie]
synonym: "glucosamine-containing compound breakdown" EXACT [GOC:bf]
synonym: "glucosamine-containing compound catabolism" EXACT [GOC:bf]
synonym: "glucosamine-containing compound degradation" EXACT [GOC:bf]
synonym: "glucosamines breakdown" EXACT [GOC:TermGenie]
synonym: "glucosamines catabolic process" EXACT [CHEBI:24271]
synonym: "glucosamines catabolism" EXACT [GOC:TermGenie]
synonym: "glucosamines degradation" EXACT [GOC:TermGenie]
is_a: GO:0046348 ! amino sugar catabolic process
is_a: GO:1901071 ! glucosamine-containing compound metabolic process
created_by: bf
creation_date: 2012-07-02T03:18:25Z

[Term]
id: GO:1901073
name: glucosamine-containing compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glucosamine-containing compounds (glucosamines)." [GOC:TermGenie]
synonym: "glucosamine-containing compound anabolism" EXACT [GOC:bf]
synonym: "glucosamine-containing compound biosynthesis" EXACT [GOC:bf]
synonym: "glucosamine-containing compound formation" EXACT [GOC:bf]
synonym: "glucosamine-containing compound synthesis" EXACT [GOC:bf]
synonym: "glucosamines anabolism" EXACT [GOC:TermGenie]
synonym: "glucosamines biosynthesis" EXACT [GOC:TermGenie]
synonym: "glucosamines biosynthetic process" EXACT [CHEBI:24271]
synonym: "glucosamines formation" EXACT [GOC:TermGenie]
synonym: "glucosamines synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046349 ! amino sugar biosynthetic process
is_a: GO:1901071 ! glucosamine-containing compound metabolic process
created_by: bf
creation_date: 2012-07-02T03:18:33Z

[Term]
id: GO:1901074
name: regulation of engulfment of apoptotic cell
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of engulfment of apoptotic cell." [GO:kmv, GOC:TermGenie, PMID:19402756]
synonym: "regulation of engulfment of apoptotic cell corpse" EXACT [GOC:TermGenie]
synonym: "regulation of engulfment of cell corpse" EXACT [GOC:TermGenie]
is_a: GO:0060099 ! regulation of phagocytosis, engulfment
is_a: GO:2000425 ! regulation of apoptotic cell clearance
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043652 ! engulfment of apoptotic cell
relationship: regulates GO:0043652 ! engulfment of apoptotic cell
created_by: kmv
creation_date: 2012-07-02T07:32:21Z

[Term]
id: GO:1901075
name: negative regulation of engulfment of apoptotic cell
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of engulfment of apoptotic cell." [GO:kmv, GOC:TermGenie, PMID:19402756]
synonym: "down regulation of engulfment of apoptotic cell" EXACT [GOC:TermGenie]
synonym: "down regulation of engulfment of apoptotic cell corpse" EXACT [GOC:TermGenie]
synonym: "down regulation of engulfment of cell corpse" EXACT [GOC:TermGenie]
synonym: "down-regulation of engulfment of apoptotic cell" EXACT [GOC:TermGenie]
synonym: "down-regulation of engulfment of apoptotic cell corpse" EXACT [GOC:TermGenie]
synonym: "down-regulation of engulfment of cell corpse" EXACT [GOC:TermGenie]
synonym: "downregulation of engulfment of apoptotic cell" EXACT [GOC:TermGenie]
synonym: "downregulation of engulfment of apoptotic cell corpse" EXACT [GOC:TermGenie]
synonym: "downregulation of engulfment of cell corpse" EXACT [GOC:TermGenie]
synonym: "inhibition of engulfment of apoptotic cell" NARROW [GOC:TermGenie]
synonym: "inhibition of engulfment of apoptotic cell corpse" NARROW [GOC:TermGenie]
synonym: "inhibition of engulfment of cell corpse" NARROW [GOC:TermGenie]
synonym: "negative regulation of engulfment of apoptotic cell corpse" EXACT [GOC:TermGenie]
synonym: "negative regulation of engulfment of cell corpse" EXACT [GOC:TermGenie]
is_a: GO:0060101 ! negative regulation of phagocytosis, engulfment
is_a: GO:1901074 ! regulation of engulfment of apoptotic cell
is_a: GO:2000426 ! negative regulation of apoptotic cell clearance
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043652 ! engulfment of apoptotic cell
relationship: negatively_regulates GO:0043652 ! engulfment of apoptotic cell
created_by: kmv
creation_date: 2012-07-02T07:32:43Z

[Term]
id: GO:1901076
name: positive regulation of engulfment of apoptotic cell
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of engulfment of apoptotic cell." [GO:kmv, GOC:TermGenie, PMID:19402756]
synonym: "activation of engulfment of apoptotic cell" NARROW [GOC:TermGenie]
synonym: "activation of engulfment of apoptotic cell corpse" NARROW [GOC:TermGenie]
synonym: "activation of engulfment of cell corpse" NARROW [GOC:TermGenie]
synonym: "positive regulation of engulfment of apoptotic cell corpse" EXACT [GOC:TermGenie]
synonym: "positive regulation of engulfment of cell corpse" EXACT [GOC:TermGenie]
synonym: "up regulation of engulfment of apoptotic cell" EXACT [GOC:TermGenie]
synonym: "up regulation of engulfment of apoptotic cell corpse" EXACT [GOC:TermGenie]
synonym: "up regulation of engulfment of cell corpse" EXACT [GOC:TermGenie]
synonym: "up-regulation of engulfment of apoptotic cell" EXACT [GOC:TermGenie]
synonym: "up-regulation of engulfment of apoptotic cell corpse" EXACT [GOC:TermGenie]
synonym: "up-regulation of engulfment of cell corpse" EXACT [GOC:TermGenie]
synonym: "upregulation of engulfment of apoptotic cell" EXACT [GOC:TermGenie]
synonym: "upregulation of engulfment of apoptotic cell corpse" EXACT [GOC:TermGenie]
synonym: "upregulation of engulfment of cell corpse" EXACT [GOC:TermGenie]
is_a: GO:0060100 ! positive regulation of phagocytosis, engulfment
is_a: GO:1901074 ! regulation of engulfment of apoptotic cell
is_a: GO:2000427 ! positive regulation of apoptotic cell clearance
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043652 ! engulfment of apoptotic cell
relationship: positively_regulates GO:0043652 ! engulfment of apoptotic cell
created_by: kmv
creation_date: 2012-07-02T07:32:51Z

[Term]
id: GO:1901077
name: regulation of relaxation of muscle
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of relaxation of muscle." [GOC:TermGenie]
is_a: GO:0090257 ! regulation of muscle system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0090075 ! relaxation of muscle
relationship: regulates GO:0090075 ! relaxation of muscle
created_by: jl
creation_date: 2012-07-04T10:44:30Z

[Term]
id: GO:1901078
name: negative regulation of relaxation of muscle
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of relaxation of muscle." [GOC:TermGenie]
synonym: "down regulation of relaxation of muscle" EXACT [GOC:TermGenie]
synonym: "down-regulation of relaxation of muscle" EXACT [GOC:TermGenie]
synonym: "downregulation of relaxation of muscle" EXACT [GOC:TermGenie]
synonym: "inhibition of relaxation of muscle" NARROW [GOC:TermGenie]
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1901077 ! regulation of relaxation of muscle
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0090075 ! relaxation of muscle
relationship: negatively_regulates GO:0090075 ! relaxation of muscle
created_by: jl
creation_date: 2012-07-04T10:44:54Z

[Term]
id: GO:1901079
name: positive regulation of relaxation of muscle
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of relaxation of muscle." [GOC:TermGenie]
synonym: "activation of relaxation of muscle" NARROW [GOC:TermGenie]
synonym: "up regulation of relaxation of muscle" EXACT [GOC:TermGenie]
synonym: "up-regulation of relaxation of muscle" EXACT [GOC:TermGenie]
synonym: "upregulation of relaxation of muscle" EXACT [GOC:TermGenie]
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1901077 ! regulation of relaxation of muscle
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0090075 ! relaxation of muscle
relationship: positively_regulates GO:0090075 ! relaxation of muscle
created_by: jl
creation_date: 2012-07-04T10:45:02Z

[Term]
id: GO:1901080
name: regulation of relaxation of smooth muscle
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of relaxation of smooth muscle." [GOC:TermGenie]
synonym: "regulation of smooth muscle relaxation" EXACT [GOC:TermGenie]
is_a: GO:1901077 ! regulation of relaxation of muscle
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044557 ! relaxation of smooth muscle
relationship: regulates GO:0044557 ! relaxation of smooth muscle
created_by: jl
creation_date: 2012-07-04T10:45:09Z

[Term]
id: GO:1901081
name: negative regulation of relaxation of smooth muscle
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of relaxation of smooth muscle." [GOC:TermGenie]
synonym: "down regulation of relaxation of smooth muscle" EXACT [GOC:TermGenie]
synonym: "down regulation of smooth muscle relaxation" EXACT [GOC:TermGenie]
synonym: "down-regulation of relaxation of smooth muscle" EXACT [GOC:TermGenie]
synonym: "down-regulation of smooth muscle relaxation" EXACT [GOC:TermGenie]
synonym: "downregulation of relaxation of smooth muscle" EXACT [GOC:TermGenie]
synonym: "downregulation of smooth muscle relaxation" EXACT [GOC:TermGenie]
synonym: "inhibition of relaxation of smooth muscle" NARROW [GOC:TermGenie]
synonym: "inhibition of smooth muscle relaxation" EXACT [GOC:TermGenie]
synonym: "negative regulation of smooth muscle relaxation" EXACT [GOC:TermGenie]
is_a: GO:1901078 ! negative regulation of relaxation of muscle
is_a: GO:1901080 ! regulation of relaxation of smooth muscle
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044557 ! relaxation of smooth muscle
relationship: negatively_regulates GO:0044557 ! relaxation of smooth muscle
created_by: jl
creation_date: 2012-07-04T10:45:31Z

[Term]
id: GO:1901082
name: positive regulation of relaxation of smooth muscle
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of relaxation of smooth muscle." [GOC:TermGenie]
synonym: "activation of relaxation of smooth muscle" NARROW [GOC:TermGenie]
synonym: "activation of smooth muscle relaxation" EXACT [GOC:TermGenie]
synonym: "positive regulation of smooth muscle relaxation" EXACT [GOC:TermGenie]
synonym: "up regulation of relaxation of smooth muscle" EXACT [GOC:TermGenie]
synonym: "up regulation of smooth muscle relaxation" EXACT [GOC:TermGenie]
synonym: "up-regulation of relaxation of smooth muscle" EXACT [GOC:TermGenie]
synonym: "up-regulation of smooth muscle relaxation" EXACT [GOC:TermGenie]
synonym: "upregulation of relaxation of smooth muscle" EXACT [GOC:TermGenie]
synonym: "upregulation of smooth muscle relaxation" EXACT [GOC:TermGenie]
is_a: GO:1901079 ! positive regulation of relaxation of muscle
is_a: GO:1901080 ! regulation of relaxation of smooth muscle
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044557 ! relaxation of smooth muscle
relationship: positively_regulates GO:0044557 ! relaxation of smooth muscle
created_by: jl
creation_date: 2012-07-04T10:45:39Z

[Term]
id: GO:1901083
name: pyrrolizidine alkaloid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pyrrolizidine alkaloid." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00329]
synonym: "pyrrolizidine alkaloid metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009820 ! alkaloid metabolic process
created_by: yaf
creation_date: 2012-07-05T10:27:56Z

[Term]
id: GO:1901084
name: pyrrolizidine alkaloid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pyrrolizidine alkaloid." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00329]
synonym: "pyrrolizidine alkaloid breakdown" EXACT [GOC:TermGenie]
synonym: "pyrrolizidine alkaloid catabolism" EXACT [GOC:TermGenie]
synonym: "pyrrolizidine alkaloid degradation" EXACT [GOC:TermGenie]
is_a: GO:0009822 ! alkaloid catabolic process
is_a: GO:1901083 ! pyrrolizidine alkaloid metabolic process
created_by: yaf
creation_date: 2012-07-05T10:28:20Z

[Term]
id: GO:1901085
name: pyrrolizidine alkaloid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyrrolizidine alkaloid." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00329]
synonym: "pyrrolizidine alkaloid anabolism" EXACT [GOC:TermGenie]
synonym: "pyrrolizidine alkaloid biosynthesis" EXACT [GOC:TermGenie]
synonym: "pyrrolizidine alkaloid formation" EXACT [GOC:TermGenie]
synonym: "pyrrolizidine alkaloid synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009821 ! alkaloid biosynthetic process
is_a: GO:1901083 ! pyrrolizidine alkaloid metabolic process
created_by: yaf
creation_date: 2012-07-05T10:28:28Z

[Term]
id: GO:1901086
name: benzylpenicillin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving benzylpenicillin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00149]
synonym: "benzylpenicillin metabolism" EXACT [GOC:TermGenie]
synonym: "penicillin G metabolism" EXACT []
is_a: GO:0042316 ! penicillin metabolic process
created_by: yaf
creation_date: 2012-07-05T10:28:33Z

[Term]
id: GO:1901087
name: benzylpenicillin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of benzylpenicillin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00149]
synonym: "benzylpenicillin breakdown" EXACT [GOC:TermGenie]
synonym: "benzylpenicillin catabolism" EXACT [GOC:TermGenie]
synonym: "benzylpenicillin degradation" EXACT [GOC:TermGenie]
synonym: "penicillin G breakdown" EXACT []
synonym: "penicillin G catabolic process" EXACT []
synonym: "penicillin G catabolism" EXACT []
synonym: "penicillin G degradation" EXACT []
is_a: GO:0042317 ! penicillin catabolic process
is_a: GO:1901086 ! benzylpenicillin metabolic process
created_by: yaf
creation_date: 2012-07-05T10:28:59Z

[Term]
id: GO:1901088
name: benzylpenicillin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of benzylpenicillin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00149]
synonym: "benzylpenicillin anabolism" EXACT [GOC:TermGenie]
synonym: "benzylpenicillin biosynthesis" EXACT [GOC:TermGenie]
synonym: "benzylpenicillin formation" EXACT [GOC:TermGenie]
synonym: "benzylpenicillin synthesis" EXACT [GOC:TermGenie]
synonym: "penicillin G anabolism" EXACT [GOC:yaf]
synonym: "penicillin G biosynthesis" EXACT [GOC:yaf]
synonym: "penicillin G formation" EXACT [GOC:yaf]
synonym: "penicillin G synthesis" EXACT [GOC:yaf]
is_a: GO:0042318 ! penicillin biosynthetic process
is_a: GO:1901086 ! benzylpenicillin metabolic process
created_by: yaf
creation_date: 2012-07-05T10:29:07Z

[Term]
id: GO:1901089
name: acetate ester metabolic process involved in fermentation
namespace: biological_process
def: "Any acetate ester metabolic process that is involved in fermentation." [GOC:sgd_curators, GOC:TermGenie]
synonym: "acetate ester metabolic process during fermentation" EXACT [GOC:sgd_curators]
is_a: GO:1900619 ! acetate ester metabolic process
intersection_of: GO:1900619 ! acetate ester metabolic process
intersection_of: part_of GO:0006113 ! fermentation
relationship: part_of GO:0006113 ! fermentation
created_by: ramab
creation_date: 2012-07-05T11:47:17Z

[Term]
id: GO:1901090
name: regulation of protein tetramerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein tetramerization." [GOC:pm, GOC:TermGenie]
synonym: "regulation of protein tetramer assembly" EXACT [GOC:TermGenie]
synonym: "regulation of protein tetramer biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of protein tetramer biosynthetic process" EXACT [GOC:TermGenie]
synonym: "regulation of protein tetramer formation" EXACT [GOC:TermGenie]
is_a: GO:0032459 ! regulation of protein oligomerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051262 ! protein tetramerization
relationship: regulates GO:0051262 ! protein tetramerization
created_by: pm
creation_date: 2012-07-06T12:51:00Z

[Term]
id: GO:1901091
name: negative regulation of protein tetramerization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein tetramerization." [GOC:pm, GOC:TermGenie]
synonym: "down regulation of protein tetramer assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of protein tetramer biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of protein tetramer biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of protein tetramer formation" EXACT [GOC:TermGenie]
synonym: "down regulation of protein tetramerization" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein tetramer assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein tetramer biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein tetramer biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein tetramer formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein tetramerization" EXACT [GOC:TermGenie]
synonym: "downregulation of protein tetramer assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of protein tetramer biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of protein tetramer biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of protein tetramer formation" EXACT [GOC:TermGenie]
synonym: "downregulation of protein tetramerization" EXACT [GOC:TermGenie]
synonym: "inhibition of protein tetramer assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of protein tetramer biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of protein tetramer biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of protein tetramer formation" NARROW [GOC:TermGenie]
synonym: "inhibition of protein tetramerization" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein tetramer assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein tetramer biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein tetramer biosynthetic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein tetramer formation" EXACT [GOC:TermGenie]
is_a: GO:0032460 ! negative regulation of protein oligomerization
is_a: GO:1901090 ! regulation of protein tetramerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051262 ! protein tetramerization
relationship: negatively_regulates GO:0051262 ! protein tetramerization
created_by: pm
creation_date: 2012-07-06T12:51:24Z

[Term]
id: GO:1901092
name: positive regulation of protein tetramerization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein tetramerization." [GOC:pm, GOC:TermGenie]
synonym: "activation of protein tetramer assembly" NARROW [GOC:TermGenie]
synonym: "activation of protein tetramer biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of protein tetramer biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of protein tetramer formation" NARROW [GOC:TermGenie]
synonym: "activation of protein tetramerization" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein tetramer assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein tetramer biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein tetramer biosynthetic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein tetramer formation" EXACT [GOC:TermGenie]
synonym: "up regulation of protein tetramer assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of protein tetramer biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of protein tetramer biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of protein tetramer formation" EXACT [GOC:TermGenie]
synonym: "up regulation of protein tetramerization" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein tetramer assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein tetramer biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein tetramer biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein tetramer formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein tetramerization" EXACT [GOC:TermGenie]
synonym: "upregulation of protein tetramer assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of protein tetramer biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of protein tetramer biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of protein tetramer formation" EXACT [GOC:TermGenie]
synonym: "upregulation of protein tetramerization" EXACT [GOC:TermGenie]
is_a: GO:0032461 ! positive regulation of protein oligomerization
is_a: GO:1901090 ! regulation of protein tetramerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051262 ! protein tetramerization
relationship: positively_regulates GO:0051262 ! protein tetramerization
created_by: pm
creation_date: 2012-07-06T12:51:32Z

[Term]
id: GO:1901093
name: regulation of protein homotetramerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein homotetramerization." [GOC:pm, GOC:TermGenie]
synonym: "regulation of protein homotetramer assembly" EXACT [GOC:TermGenie]
synonym: "regulation of protein homotetramer biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of protein homotetramer biosynthetic process" EXACT [GOC:TermGenie]
synonym: "regulation of protein homotetramer formation" EXACT [GOC:TermGenie]
is_a: GO:0032462 ! regulation of protein homooligomerization
is_a: GO:1901090 ! regulation of protein tetramerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051289 ! protein homotetramerization
relationship: regulates GO:0051289 ! protein homotetramerization
created_by: pm
creation_date: 2012-07-06T12:57:33Z

[Term]
id: GO:1901094
name: negative regulation of protein homotetramerization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein homotetramerization." [GOC:pm, GOC:TermGenie]
synonym: "down regulation of protein homotetramer assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of protein homotetramer biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of protein homotetramer biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of protein homotetramer formation" EXACT [GOC:TermGenie]
synonym: "down regulation of protein homotetramerization" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein homotetramer assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein homotetramer biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein homotetramer biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein homotetramer formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein homotetramerization" EXACT [GOC:TermGenie]
synonym: "downregulation of protein homotetramer assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of protein homotetramer biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of protein homotetramer biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of protein homotetramer formation" EXACT [GOC:TermGenie]
synonym: "downregulation of protein homotetramerization" EXACT [GOC:TermGenie]
synonym: "inhibition of protein homotetramer assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of protein homotetramer biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of protein homotetramer biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of protein homotetramer formation" NARROW [GOC:TermGenie]
synonym: "inhibition of protein homotetramerization" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein homotetramer assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein homotetramer biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein homotetramer biosynthetic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein homotetramer formation" EXACT [GOC:TermGenie]
is_a: GO:0032463 ! negative regulation of protein homooligomerization
is_a: GO:1901091 ! negative regulation of protein tetramerization
is_a: GO:1901093 ! regulation of protein homotetramerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051289 ! protein homotetramerization
relationship: negatively_regulates GO:0051289 ! protein homotetramerization
created_by: pm
creation_date: 2012-07-06T12:57:58Z

[Term]
id: GO:1901095
name: positive regulation of protein homotetramerization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein homotetramerization." [GOC:pm, GOC:TermGenie]
synonym: "activation of protein homotetramer assembly" NARROW [GOC:TermGenie]
synonym: "activation of protein homotetramer biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of protein homotetramer biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of protein homotetramer formation" NARROW [GOC:TermGenie]
synonym: "activation of protein homotetramerization" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein homotetramer assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein homotetramer biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein homotetramer biosynthetic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein homotetramer formation" EXACT [GOC:TermGenie]
synonym: "up regulation of protein homotetramer assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of protein homotetramer biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of protein homotetramer biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of protein homotetramer formation" EXACT [GOC:TermGenie]
synonym: "up regulation of protein homotetramerization" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein homotetramer assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein homotetramer biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein homotetramer biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein homotetramer formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein homotetramerization" EXACT [GOC:TermGenie]
synonym: "upregulation of protein homotetramer assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of protein homotetramer biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of protein homotetramer biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of protein homotetramer formation" EXACT [GOC:TermGenie]
synonym: "upregulation of protein homotetramerization" EXACT [GOC:TermGenie]
is_a: GO:0032464 ! positive regulation of protein homooligomerization
is_a: GO:1901092 ! positive regulation of protein tetramerization
is_a: GO:1901093 ! regulation of protein homotetramerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051289 ! protein homotetramerization
relationship: positively_regulates GO:0051289 ! protein homotetramerization
created_by: pm
creation_date: 2012-07-06T12:58:06Z

[Term]
id: GO:1901096
name: regulation of autophagosome maturation
namespace: biological_process
alt_id: GO:1902452
def: "Any process that modulates the frequency, rate or extent of autophagosome maturation." [GOC:autophagy, GOC:TermGenie, PMID:10436019, PMID:21383079]
synonym: "regulation of amphisome-lysosome fusion" NARROW [GOC:TermGenie]
synonym: "regulation of autolysosome formation" NARROW [GOC:TermGenie]
synonym: "regulation of autophagic vacuole fusion" EXACT [GOC:autophagy]
synonym: "regulation of autophagosome fusion" EXACT []
synonym: "regulation of autophagosome maturation" EXACT [GOC:TermGenie]
synonym: "regulation of fusion of autophagosome with lysosome" NARROW [GOC:TermGenie]
is_a: GO:0016241 ! regulation of macroautophagy
is_a: GO:0044088 ! regulation of vacuole organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097352 ! autophagosome maturation
relationship: regulates GO:0097352 ! autophagosome maturation
created_by: lb
creation_date: 2012-07-10T07:22:01Z

[Term]
id: GO:1901097
name: negative regulation of autophagosome maturation
namespace: biological_process
alt_id: GO:1902453
def: "Any process that stops, prevents or reduces the frequency, rate or extent of autophagosome maturation." [GOC:autophagy, GOC:TermGenie, PMID:10436019, PMID:21383079]
synonym: "down regulation of amphisome-lysosome fusion" NARROW [GOC:TermGenie]
synonym: "down regulation of autolysosome formation" NARROW [GOC:TermGenie]
synonym: "down regulation of autophagic vacuole fusion" EXACT [GOC:TermGenie]
synonym: "down regulation of autophagic vacuole maturation" EXACT [GOC:TermGenie]
synonym: "down regulation of autophagosome maturation" EXACT [GOC:TermGenie]
synonym: "down regulation of fusion of autophagosome with lysosome" NARROW [GOC:TermGenie]
synonym: "down-regulation of amphisome-lysosome fusion" NARROW [GOC:TermGenie]
synonym: "down-regulation of autolysosome formation" NARROW [GOC:TermGenie]
synonym: "down-regulation of autophagic vacuole fusion" EXACT [GOC:TermGenie]
synonym: "down-regulation of autophagic vacuole maturation" EXACT [GOC:TermGenie]
synonym: "down-regulation of autophagosome maturation" EXACT [GOC:TermGenie]
synonym: "down-regulation of fusion of autophagosome with lysosome" NARROW [GOC:TermGenie]
synonym: "downregulation of amphisome-lysosome fusion" NARROW [GOC:TermGenie]
synonym: "downregulation of autolysosome formation" NARROW [GOC:TermGenie]
synonym: "downregulation of autophagic vacuole fusion" EXACT [GOC:TermGenie]
synonym: "downregulation of autophagic vacuole maturation" EXACT [GOC:TermGenie]
synonym: "downregulation of autophagosome maturation" EXACT [GOC:TermGenie]
synonym: "downregulation of fusion of autophagosome with lysosome" NARROW [GOC:TermGenie]
synonym: "inhibition of amphisome-lysosome fusion" NARROW [GOC:TermGenie]
synonym: "inhibition of autolysosome formation" NARROW [GOC:TermGenie]
synonym: "inhibition of autophagic vacuole fusion" NARROW [GOC:TermGenie]
synonym: "inhibition of autophagic vacuole maturation" NARROW [GOC:TermGenie]
synonym: "inhibition of autophagosome maturation" EXACT [GOC:TermGenie]
synonym: "inhibition of fusion of autophagosome with lysosome" NARROW [GOC:TermGenie]
synonym: "negative regulation of amphisome-lysosome fusion" NARROW [GOC:TermGenie]
synonym: "negative regulation of autolysosome formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of autophagic vacuole fusion" EXACT [GOC:autophagy]
synonym: "negative regulation of autophagosome fusion" EXACT []
synonym: "negative regulation of autophagosome maturation" EXACT [GOC:TermGenie]
synonym: "negative regulation of fusion of autophagosome with lysosome" NARROW [GOC:TermGenie]
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:0016242 ! negative regulation of macroautophagy
is_a: GO:1901096 ! regulation of autophagosome maturation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097352 ! autophagosome maturation
relationship: negatively_regulates GO:0097352 ! autophagosome maturation
created_by: lb
creation_date: 2012-07-10T07:22:26Z

[Term]
id: GO:1901098
name: positive regulation of autophagosome maturation
namespace: biological_process
alt_id: GO:1902454
def: "Any process that activates or increases the frequency, rate or extent of autophagosome maturation." [GOC:autophagy, GOC:TermGenie, PMID:10436019, PMID:21383079]
synonym: "activation of amphisome-lysosome fusion" NARROW [GOC:TermGenie]
synonym: "activation of autolysosome formation" NARROW [GOC:TermGenie]
synonym: "activation of autophagic vacuole fusion" NARROW [GOC:TermGenie]
synonym: "activation of autophagic vacuole maturation" NARROW [GOC:TermGenie]
synonym: "activation of autophagosome maturation" EXACT [GOC:TermGenie]
synonym: "activation of fusion of autophagosome with lysosome" NARROW [GOC:TermGenie]
synonym: "positive regulation of amphisome-lysosome fusion" NARROW [GOC:TermGenie]
synonym: "positive regulation of autolysosome formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of autophagic vacuole fusion" EXACT [GOC:autophagy]
synonym: "positive regulation of autophagosome fusion" EXACT []
synonym: "positive regulation of autophagosome maturation" EXACT [GOC:TermGenie]
synonym: "positive regulation of fusion of autophagosome with lysosome" NARROW [GOC:TermGenie]
synonym: "up regulation of amphisome-lysosome fusion" NARROW [GOC:TermGenie]
synonym: "up regulation of autolysosome formation" NARROW [GOC:TermGenie]
synonym: "up regulation of autophagic vacuole fusion" EXACT [GOC:TermGenie]
synonym: "up regulation of autophagic vacuole maturation" EXACT [GOC:TermGenie]
synonym: "up regulation of autophagosome maturation" EXACT [GOC:TermGenie]
synonym: "up regulation of fusion of autophagosome with lysosome" NARROW [GOC:TermGenie]
synonym: "up-regulation of amphisome-lysosome fusion" NARROW [GOC:TermGenie]
synonym: "up-regulation of autolysosome formation" NARROW [GOC:TermGenie]
synonym: "up-regulation of autophagic vacuole fusion" EXACT [GOC:TermGenie]
synonym: "up-regulation of autophagic vacuole maturation" EXACT [GOC:TermGenie]
synonym: "up-regulation of autophagosome maturation" EXACT [GOC:TermGenie]
synonym: "up-regulation of fusion of autophagosome with lysosome" NARROW [GOC:TermGenie]
synonym: "upregulation of amphisome-lysosome fusion" NARROW [GOC:TermGenie]
synonym: "upregulation of autolysosome formation" NARROW [GOC:TermGenie]
synonym: "upregulation of autophagic vacuole fusion" EXACT [GOC:TermGenie]
synonym: "upregulation of autophagic vacuole maturation" EXACT [GOC:TermGenie]
synonym: "upregulation of autophagosome maturation" EXACT [GOC:TermGenie]
synonym: "upregulation of fusion of autophagosome with lysosome" NARROW [GOC:TermGenie]
is_a: GO:0016239 ! positive regulation of macroautophagy
is_a: GO:0044090 ! positive regulation of vacuole organization
is_a: GO:1901096 ! regulation of autophagosome maturation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097352 ! autophagosome maturation
relationship: positively_regulates GO:0097352 ! autophagosome maturation
created_by: lb
creation_date: 2012-07-10T07:22:34Z

[Term]
id: GO:1901099
name: negative regulation of signal transduction in absence of ligand
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction in absence of ligand." [GOC:TermGenie]
synonym: "down regulation of basal signaling" NARROW [GOC:TermGenie]
synonym: "down regulation of non-classical signal transduction" BROAD [GOC:TermGenie]
synonym: "down regulation of signal transduction in absence of agonist" EXACT [GOC:TermGenie]
synonym: "down regulation of signal transduction in absence of ligand" EXACT [GOC:TermGenie]
synonym: "down-regulation of basal signaling" NARROW [GOC:TermGenie]
synonym: "down-regulation of non-classical signal transduction" BROAD [GOC:TermGenie]
synonym: "down-regulation of signal transduction in absence of agonist" EXACT [GOC:TermGenie]
synonym: "down-regulation of signal transduction in absence of ligand" EXACT [GOC:TermGenie]
synonym: "downregulation of basal signaling" NARROW [GOC:TermGenie]
synonym: "downregulation of non-classical signal transduction" BROAD [GOC:TermGenie]
synonym: "downregulation of signal transduction in absence of agonist" EXACT [GOC:TermGenie]
synonym: "downregulation of signal transduction in absence of ligand" EXACT [GOC:TermGenie]
synonym: "inhibition of signal transduction in absence of ligand" NARROW [GOC:TermGenie]
synonym: "negative regulation of non-classical signal transduction" BROAD [GOC:TermGenie]
synonym: "negative regulation of signal transduction in absence of agonist" EXACT [GOC:TermGenie]
is_a: GO:0009968 ! negative regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0038034 ! signal transduction in absence of ligand
relationship: negatively_regulates GO:0038034 ! signal transduction in absence of ligand
created_by: al
creation_date: 2012-07-10T10:31:08Z

[Term]
id: GO:1901101
name: gramicidin S metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving gramicidin S." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00102]
synonym: "gramicidin S metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006518 ! peptide metabolic process
created_by: yaf
creation_date: 2012-07-11T02:30:26Z

[Term]
id: GO:1901102
name: gramicidin S catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of gramicidin S." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00102]
synonym: "gramicidin S breakdown" EXACT [GOC:TermGenie]
synonym: "gramicidin S catabolism" EXACT [GOC:TermGenie]
synonym: "gramicidin S degradation" EXACT [GOC:TermGenie]
is_a: GO:0043171 ! peptide catabolic process
is_a: GO:1901101 ! gramicidin S metabolic process
created_by: yaf
creation_date: 2012-07-11T02:30:52Z

[Term]
id: GO:1901103
name: gramicidin S biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of gramicidin S." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00102]
synonym: "gramicidin S anabolism" EXACT [GOC:TermGenie]
synonym: "gramicidin S biosynthesis" EXACT [GOC:TermGenie]
synonym: "gramicidin S formation" EXACT [GOC:TermGenie]
synonym: "gramicidin S synthesis" EXACT [GOC:TermGenie]
is_a: GO:0043043 ! peptide biosynthetic process
is_a: GO:1901101 ! gramicidin S metabolic process
created_by: yaf
creation_date: 2012-07-11T02:31:00Z

[Term]
id: GO:1901104
name: tetracenomycin C metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tetracenomycin C." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00174]
synonym: "tetracenomycin C metabolism" EXACT [GOC:TermGenie]
is_a: GO:0030638 ! polyketide metabolic process
created_by: yaf
creation_date: 2012-07-11T02:50:32Z

[Term]
id: GO:1901105
name: tetracenomycin C catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tetracenomycin C." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00174]
synonym: "tetracenomycin C breakdown" EXACT [GOC:TermGenie]
synonym: "tetracenomycin C catabolism" EXACT [GOC:TermGenie]
synonym: "tetracenomycin C degradation" EXACT [GOC:TermGenie]
is_a: GO:0030640 ! polyketide catabolic process
is_a: GO:1901104 ! tetracenomycin C metabolic process
created_by: yaf
creation_date: 2012-07-11T02:50:54Z

[Term]
id: GO:1901106
name: tetracenomycin C biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tetracenomycin C." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00174]
synonym: "tetracenomycin C anabolism" EXACT [GOC:TermGenie]
synonym: "tetracenomycin C biosynthesis" EXACT [GOC:TermGenie]
synonym: "tetracenomycin C formation" EXACT [GOC:TermGenie]
synonym: "tetracenomycin C synthesis" EXACT [GOC:TermGenie]
is_a: GO:0030639 ! polyketide biosynthetic process
is_a: GO:1901104 ! tetracenomycin C metabolic process
created_by: yaf
creation_date: 2012-07-11T02:51:03Z

[Term]
id: GO:1901107
name: granaticin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving granaticin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00175]
synonym: "granaticin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0030638 ! polyketide metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901661 ! quinone metabolic process
created_by: yaf
creation_date: 2012-07-11T02:51:08Z

[Term]
id: GO:1901108
name: granaticin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of granaticin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00175]
synonym: "granaticin breakdown" EXACT [GOC:TermGenie]
synonym: "granaticin catabolism" EXACT [GOC:TermGenie]
synonym: "granaticin degradation" EXACT [GOC:TermGenie]
is_a: GO:0030640 ! polyketide catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1901107 ! granaticin metabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901662 ! quinone catabolic process
created_by: yaf
creation_date: 2012-07-11T02:51:33Z

[Term]
id: GO:1901109
name: granaticin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of granaticin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00175]
synonym: "granaticin anabolism" EXACT [GOC:TermGenie]
synonym: "granaticin biosynthesis" EXACT [GOC:TermGenie]
synonym: "granaticin formation" EXACT [GOC:TermGenie]
synonym: "granaticin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0030639 ! polyketide biosynthetic process
is_a: GO:1901107 ! granaticin metabolic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901663 ! quinone biosynthetic process
created_by: yaf
creation_date: 2012-07-11T02:51:40Z

[Term]
id: GO:1901110
name: actinorhodin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving actinorhodin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00173]
synonym: "actinorhodin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0030638 ! polyketide metabolic process
is_a: GO:0043648 ! dicarboxylic acid metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901661 ! quinone metabolic process
created_by: yaf
creation_date: 2012-07-11T03:05:37Z

[Term]
id: GO:1901111
name: actinorhodin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of actinorhodin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00173]
synonym: "actinorhodin breakdown" EXACT [GOC:TermGenie]
synonym: "actinorhodin catabolism" EXACT [GOC:TermGenie]
synonym: "actinorhodin degradation" EXACT [GOC:TermGenie]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0030640 ! polyketide catabolic process
is_a: GO:0043649 ! dicarboxylic acid catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1901110 ! actinorhodin metabolic process
is_a: GO:1901662 ! quinone catabolic process
created_by: yaf
creation_date: 2012-07-11T03:06:00Z

[Term]
id: GO:1901112
name: actinorhodin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of actinorhodin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00173]
synonym: "actinorhodin anabolism" EXACT [GOC:TermGenie]
synonym: "actinorhodin biosynthesis" EXACT [GOC:TermGenie]
synonym: "actinorhodin formation" EXACT [GOC:TermGenie]
synonym: "actinorhodin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0030639 ! polyketide biosynthetic process
is_a: GO:0043650 ! dicarboxylic acid biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:1901110 ! actinorhodin metabolic process
is_a: GO:1901663 ! quinone biosynthetic process
created_by: yaf
creation_date: 2012-07-11T03:06:08Z

[Term]
id: GO:1901113
name: erythromycin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving erythromycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00240]
synonym: "erythromycin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0033067 ! macrolide metabolic process
is_a: GO:0097164 ! ammonium ion metabolic process
created_by: yaf
creation_date: 2012-07-11T03:06:13Z

[Term]
id: GO:1901114
name: erythromycin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of erythromycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00240]
synonym: "erythromycin breakdown" EXACT [GOC:TermGenie]
synonym: "erythromycin catabolism" EXACT [GOC:TermGenie]
synonym: "erythromycin degradation" EXACT [GOC:TermGenie]
is_a: GO:0030640 ! polyketide catabolic process
is_a: GO:1901113 ! erythromycin metabolic process
is_a: GO:1901335 ! lactone catabolic process
created_by: yaf
creation_date: 2012-07-11T03:06:38Z

[Term]
id: GO:1901115
name: erythromycin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of erythromycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00240]
synonym: "erythromycin anabolism" EXACT [GOC:TermGenie]
synonym: "erythromycin biosynthesis" EXACT [GOC:TermGenie]
synonym: "erythromycin formation" EXACT [GOC:TermGenie]
synonym: "erythromycin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0033068 ! macrolide biosynthetic process
is_a: GO:1901113 ! erythromycin metabolic process
created_by: yaf
creation_date: 2012-07-11T03:06:46Z

[Term]
id: GO:1901116
name: cephamycin C metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cephamycin C." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00183]
synonym: "cephamycin C metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0030653 ! beta-lactam antibiotic metabolic process
created_by: yaf
creation_date: 2012-07-11T03:06:51Z

[Term]
id: GO:1901117
name: cephamycin C catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cephamycin C." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00183]
synonym: "cephamycin C breakdown" EXACT [GOC:TermGenie]
synonym: "cephamycin C catabolism" EXACT [GOC:TermGenie]
synonym: "cephamycin C degradation" EXACT [GOC:TermGenie]
is_a: GO:0030655 ! beta-lactam antibiotic catabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:1901116 ! cephamycin C metabolic process
created_by: yaf
creation_date: 2012-07-11T03:07:13Z

[Term]
id: GO:1901118
name: cephamycin C biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cephamycin C." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00183]
synonym: "cephamycin C anabolism" EXACT [GOC:TermGenie]
synonym: "cephamycin C biosynthesis" EXACT [GOC:TermGenie]
synonym: "cephamycin C formation" EXACT [GOC:TermGenie]
synonym: "cephamycin C synthesis" EXACT [GOC:TermGenie]
is_a: GO:0030654 ! beta-lactam antibiotic biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:1901116 ! cephamycin C metabolic process
created_by: yaf
creation_date: 2012-07-11T03:07:21Z

[Term]
id: GO:1901119
name: tobramycin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tobramycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00971]
synonym: "tobramycin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0016137 ! glycoside metabolic process
is_a: GO:0019751 ! polyol metabolic process
is_a: GO:0097164 ! ammonium ion metabolic process
created_by: yaf
creation_date: 2012-07-11T03:15:19Z

[Term]
id: GO:1901120
name: tobramycin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tobramycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00971]
synonym: "tobramycin breakdown" EXACT [GOC:TermGenie]
synonym: "tobramycin catabolism" EXACT [GOC:TermGenie]
synonym: "tobramycin degradation" EXACT [GOC:TermGenie]
is_a: GO:0016139 ! glycoside catabolic process
is_a: GO:0046174 ! polyol catabolic process
is_a: GO:1901119 ! tobramycin metabolic process
created_by: yaf
creation_date: 2012-07-11T03:15:43Z

[Term]
id: GO:1901121
name: tobramycin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tobramycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00971]
synonym: "tobramycin anabolism" EXACT [GOC:TermGenie]
synonym: "tobramycin biosynthesis" EXACT [GOC:TermGenie]
synonym: "tobramycin formation" EXACT [GOC:TermGenie]
synonym: "tobramycin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0016138 ! glycoside biosynthetic process
is_a: GO:0046173 ! polyol biosynthetic process
is_a: GO:1901119 ! tobramycin metabolic process
created_by: yaf
creation_date: 2012-07-11T03:15:51Z

[Term]
id: GO:1901122
name: bacitracin A metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving bacitracin A." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00179]
synonym: "bacitracin A metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006518 ! peptide metabolic process
created_by: yaf
creation_date: 2012-07-11T03:15:56Z

[Term]
id: GO:1901123
name: bacitracin A catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of bacitracin A." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00179]
synonym: "bacitracin A breakdown" EXACT [GOC:TermGenie]
synonym: "bacitracin A catabolism" EXACT [GOC:TermGenie]
synonym: "bacitracin A degradation" EXACT [GOC:TermGenie]
is_a: GO:0043171 ! peptide catabolic process
is_a: GO:1901122 ! bacitracin A metabolic process
created_by: yaf
creation_date: 2012-07-11T03:16:20Z

[Term]
id: GO:1901124
name: bacitracin A biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of bacitracin A." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00179]
synonym: "bacitracin A anabolism" EXACT [GOC:TermGenie]
synonym: "bacitracin A biosynthesis" EXACT [GOC:TermGenie]
synonym: "bacitracin A formation" EXACT [GOC:TermGenie]
synonym: "bacitracin A synthesis" EXACT [GOC:TermGenie]
is_a: GO:0043043 ! peptide biosynthetic process
is_a: GO:1901122 ! bacitracin A metabolic process
created_by: yaf
creation_date: 2012-07-11T03:16:27Z

[Term]
id: GO:1901125
name: candicidin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving candicidin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00101]
synonym: "candicidin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0033067 ! macrolide metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process
created_by: yaf
creation_date: 2012-07-11T03:16:32Z

[Term]
id: GO:1901126
name: candicidin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of candicidin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00101]
synonym: "candicidin breakdown" EXACT [GOC:TermGenie]
synonym: "candicidin catabolism" EXACT [GOC:TermGenie]
synonym: "candicidin degradation" EXACT [GOC:TermGenie]
is_a: GO:0030640 ! polyketide catabolic process
is_a: GO:1901125 ! candicidin metabolic process
is_a: GO:1901335 ! lactone catabolic process
is_a: GO:1901616 ! organic hydroxy compound catabolic process
created_by: yaf
creation_date: 2012-07-11T03:16:54Z

[Term]
id: GO:1901127
name: candicidin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of candicidin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00101]
synonym: "candicidin anabolism" EXACT [GOC:TermGenie]
synonym: "candicidin biosynthesis" EXACT [GOC:TermGenie]
synonym: "candicidin formation" EXACT [GOC:TermGenie]
synonym: "candicidin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0033068 ! macrolide biosynthetic process
is_a: GO:1901125 ! candicidin metabolic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process
created_by: yaf
creation_date: 2012-07-11T03:17:02Z

[Term]
id: GO:1901128
name: gentamycin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving gentamycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00967]
synonym: "gentamycin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019751 ! polyol metabolic process
is_a: GO:0030647 ! aminoglycoside antibiotic metabolic process
created_by: yaf
creation_date: 2012-07-11T03:26:25Z

[Term]
id: GO:1901129
name: gentamycin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of gentamycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00967]
synonym: "gentamycin breakdown" EXACT [GOC:TermGenie]
synonym: "gentamycin catabolism" EXACT [GOC:TermGenie]
synonym: "gentamycin degradation" EXACT [GOC:TermGenie]
is_a: GO:0030649 ! aminoglycoside antibiotic catabolic process
is_a: GO:0046174 ! polyol catabolic process
is_a: GO:1901128 ! gentamycin metabolic process
created_by: yaf
creation_date: 2012-07-11T03:26:51Z

[Term]
id: GO:1901130
name: gentamycin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of gentamycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00967]
synonym: "gentamycin anabolism" EXACT [GOC:TermGenie]
synonym: "gentamycin biosynthesis" EXACT [GOC:TermGenie]
synonym: "gentamycin formation" EXACT [GOC:TermGenie]
synonym: "gentamycin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0030648 ! aminoglycoside antibiotic biosynthetic process
is_a: GO:0046173 ! polyol biosynthetic process
is_a: GO:1901128 ! gentamycin metabolic process
created_by: yaf
creation_date: 2012-07-11T03:26:59Z

[Term]
id: GO:1901131
name: kanamycin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving kanamycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00965]
synonym: "kanamycin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019751 ! polyol metabolic process
is_a: GO:0030647 ! aminoglycoside antibiotic metabolic process
created_by: yaf
creation_date: 2012-07-11T03:27:04Z

[Term]
id: GO:1901132
name: kanamycin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of kanamycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00965]
synonym: "kanamycin breakdown" EXACT [GOC:TermGenie]
synonym: "kanamycin catabolism" EXACT [GOC:TermGenie]
synonym: "kanamycin degradation" EXACT [GOC:TermGenie]
is_a: GO:0030649 ! aminoglycoside antibiotic catabolic process
is_a: GO:0046174 ! polyol catabolic process
is_a: GO:1901131 ! kanamycin metabolic process
created_by: yaf
creation_date: 2012-07-11T03:27:24Z

[Term]
id: GO:1901133
name: kanamycin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of kanamycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00965]
synonym: "kanamycin anabolism" EXACT [GOC:TermGenie]
synonym: "kanamycin biosynthesis" EXACT [GOC:TermGenie]
synonym: "kanamycin formation" EXACT [GOC:TermGenie]
synonym: "kanamycin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0030648 ! aminoglycoside antibiotic biosynthetic process
is_a: GO:0046173 ! polyol biosynthetic process
is_a: GO:1901131 ! kanamycin metabolic process
created_by: yaf
creation_date: 2012-07-11T03:27:32Z

[Term]
id: GO:1901134
name: negative regulation of coflocculation via protein-carbohydrate interaction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of coflocculation via protein-carbohydrate interaction." [GOC:TermGenie, PMID:11472912]
synonym: "down regulation of coflocculation via lectin-mannose interaction" NARROW [GOC:TermGenie]
synonym: "down regulation of coflocculation via protein-carbohydrate interaction" EXACT [GOC:TermGenie]
synonym: "down-regulation of coflocculation via lectin-mannose interaction" NARROW [GOC:TermGenie]
synonym: "down-regulation of coflocculation via protein-carbohydrate interaction" EXACT [GOC:TermGenie]
synonym: "downregulation of coflocculation via lectin-mannose interaction" NARROW [GOC:TermGenie]
synonym: "downregulation of coflocculation via protein-carbohydrate interaction" EXACT [GOC:TermGenie]
synonym: "inhibition of coflocculation via lectin-mannose interaction" NARROW [GOC:TermGenie]
synonym: "inhibition of coflocculation via protein-carbohydrate interaction" NARROW [GOC:TermGenie]
synonym: "negative regulation of coflocculation via lectin-mannose interaction" NARROW [GOC:TermGenie]
is_a: GO:0043901 ! negative regulation of multi-organism process
is_a: GO:0048523 ! negative regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0036282 ! coflocculation via protein-carbohydrate interaction
relationship: negatively_regulates GO:0036282 ! coflocculation via protein-carbohydrate interaction
created_by: al
creation_date: 2012-07-12T07:17:11Z

[Term]
id: GO:1901135
name: carbohydrate derivative metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving carbohydrate derivative." [GOC:TermGenie]
synonym: "carbohydrate derivative metabolism" EXACT [GOC:TermGenie]
is_a: GO:0071704 ! organic substance metabolic process
created_by: bf
creation_date: 2012-07-12T04:05:09Z

[Term]
id: GO:1901136
name: carbohydrate derivative catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of carbohydrate derivative." [GOC:TermGenie]
synonym: "carbohydrate derivative breakdown" EXACT [GOC:TermGenie]
synonym: "carbohydrate derivative catabolism" EXACT [GOC:TermGenie]
synonym: "carbohydrate derivative degradation" EXACT [GOC:TermGenie]
is_a: GO:1901135 ! carbohydrate derivative metabolic process
is_a: GO:1901575 ! organic substance catabolic process
created_by: bf
creation_date: 2012-07-12T04:05:31Z

[Term]
id: GO:1901137
name: carbohydrate derivative biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of carbohydrate derivative." [GOC:TermGenie]
synonym: "carbohydrate derivative anabolism" EXACT [GOC:TermGenie]
synonym: "carbohydrate derivative biosynthesis" EXACT [GOC:TermGenie]
synonym: "carbohydrate derivative formation" EXACT [GOC:TermGenie]
synonym: "carbohydrate derivative synthesis" EXACT [GOC:TermGenie]
is_a: GO:1901135 ! carbohydrate derivative metabolic process
is_a: GO:1901576 ! organic substance biosynthetic process
created_by: bf
creation_date: 2012-07-12T04:05:39Z

[Term]
id: GO:1901140
name: p-coumaryl alcohol transport
namespace: biological_process
def: "The directed movement of a p-coumaryl alcohol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:TermGenie]
synonym: "4-hydroxycinnamyl alcohol transport" EXACT []
is_a: GO:0015850 ! organic hydroxy compound transport
created_by: tb
creation_date: 2012-07-12T09:46:16Z

[Term]
id: GO:1901141
name: regulation of lignin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lignin biosynthetic process." [GOC:TermGenie]
synonym: "regulation of lignin anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of lignin biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of lignin formation" EXACT [GOC:TermGenie]
synonym: "regulation of lignin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
is_a: GO:2000762 ! regulation of phenylpropanoid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009809 ! lignin biosynthetic process
relationship: regulates GO:0009809 ! lignin biosynthetic process
created_by: tb
creation_date: 2012-07-12T09:53:09Z

[Term]
id: GO:1901142
name: insulin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving insulin." [GOC:TermGenie]
synonym: "insulin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019538 ! protein metabolic process
created_by: pm
creation_date: 2012-07-13T12:32:40Z

[Term]
id: GO:1901143
name: insulin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of insulin." [GOC:TermGenie]
synonym: "insulin breakdown" EXACT [GOC:TermGenie]
synonym: "insulin catabolism" EXACT [GOC:TermGenie]
synonym: "insulin degradation" EXACT [GOC:TermGenie]
is_a: GO:0030163 ! protein catabolic process
is_a: GO:1901142 ! insulin metabolic process
created_by: pm
creation_date: 2012-07-13T12:33:03Z

[Term]
id: GO:1901144
name: obsolete insulin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of insulin." [GOC:TermGenie]
synonym: "insulin anabolism" EXACT [GOC:TermGenie]
synonym: "insulin biosynthesis" EXACT [GOC:TermGenie]
synonym: "insulin biosynthetic process" EXACT []
synonym: "insulin formation" EXACT [GOC:TermGenie]
synonym: "insulin synthesis" EXACT [GOC:TermGenie]
is_obsolete: true
created_by: pm
creation_date: 2012-07-13T12:33:10Z

[Term]
id: GO:1901145
name: mesenchymal cell apoptotic process involved in nephron morphogenesis
namespace: biological_process
def: "Any mesenchymal cell apoptotic process that is involved in nephron morphogenesis." [GOC:mtg_apoptosis, GOC:TermGenie]
is_a: GO:0060561 ! apoptotic process involved in morphogenesis
is_a: GO:0097152 ! mesenchymal cell apoptotic process
intersection_of: GO:0097152 ! mesenchymal cell apoptotic process
intersection_of: part_of GO:0072028 ! nephron morphogenesis
relationship: part_of GO:0072028 ! nephron morphogenesis
created_by: pr
creation_date: 2012-07-13T01:43:51Z

[Term]
id: GO:1901146
name: mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis
namespace: biological_process
def: "Any mesenchymal cell apoptotic process that is involved in mesonephric nephron morphogenesis." [GOC:mtg_apoptosis, GOC:TermGenie]
is_a: GO:1901145 ! mesenchymal cell apoptotic process involved in nephron morphogenesis
intersection_of: GO:0097152 ! mesenchymal cell apoptotic process
intersection_of: part_of GO:0061228 ! mesonephric nephron morphogenesis
relationship: part_of GO:0061228 ! mesonephric nephron morphogenesis
created_by: pr
creation_date: 2012-07-13T02:40:43Z

[Term]
id: GO:1901147
name: mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis
namespace: biological_process
def: "Any mesenchymal cell apoptotic process that is involved in metanephric nephron morphogenesis." [GOC:mtg_apoptosis, GOC:TermGenie]
is_a: GO:1900200 ! mesenchymal cell apoptotic process involved in metanephros development
is_a: GO:1901145 ! mesenchymal cell apoptotic process involved in nephron morphogenesis
intersection_of: GO:0097152 ! mesenchymal cell apoptotic process
intersection_of: part_of GO:0072273 ! metanephric nephron morphogenesis
relationship: part_of GO:0072273 ! metanephric nephron morphogenesis
created_by: pr
creation_date: 2012-07-13T02:41:12Z

[Term]
id: GO:1901148
name: gene expression involved in extracellular matrix organization
namespace: biological_process
def: "Any gene expression that is involved in extracellular matrix organization. Gene expression includes both transcription to produce an RNA transcript, and the translation of that mRNA into protein. Protein maturation is included in gene expression when required to form an active form of a product from an inactive precursor form." [GOC:pg, GOC:TermGenie, PMID:18668558]
synonym: "expression of extracellular matrix proteins" EXACT [GOC:bf]
synonym: "extracellular matrix protein production" RELATED [GOC:pg]
is_a: GO:0010467 ! gene expression
intersection_of: GO:0010467 ! gene expression
intersection_of: part_of GO:0030198 ! extracellular matrix organization
relationship: part_of GO:0030198 ! extracellular matrix organization
created_by: bf
creation_date: 2012-07-16T03:29:30Z

[Term]
id: GO:1901149
name: salicylic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with salicylic acid." [GOC:TermGenie, PMID:22699612]
synonym: "salicylic acid receptor" NARROW [PMID:22699612]
is_a: GO:0033293 ! monocarboxylic acid binding
is_a: GO:0097159 ! organic cyclic compound binding
created_by: dhl
creation_date: 2012-07-16T05:26:38Z

[Term]
id: GO:1901150
name: vistamycin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving vistamycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00972]
synonym: "ribostamycin metabolic process" EXACT [GOC:yaf]
synonym: "ribostamycin metabolism" EXACT [GOC:yaf]
synonym: "vistamycin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0006807 ! nitrogen compound metabolic process
is_a: GO:0016137 ! glycoside metabolic process
is_a: GO:0044763 ! single-organism cellular process
created_by: yaf
creation_date: 2012-07-17T04:26:45Z

[Term]
id: GO:1901151
name: vistamycin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of vistamycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00972]
synonym: "ribostamycin breakdown" EXACT [GOC:yaf]
synonym: "ribostamycin catabolic process" EXACT [GOC:yaf]
synonym: "ribostamycin catabolism" EXACT [GOC:yaf]
synonym: "ribostamycin degradation" EXACT [GOC:yaf]
synonym: "vistamycin breakdown" EXACT [GOC:TermGenie]
synonym: "vistamycin catabolism" EXACT [GOC:TermGenie]
synonym: "vistamycin degradation" EXACT [GOC:TermGenie]
is_a: GO:0016139 ! glycoside catabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:1901150 ! vistamycin metabolic process
created_by: yaf
creation_date: 2012-07-17T04:27:07Z

[Term]
id: GO:1901152
name: vistamycin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of vistamycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00972]
synonym: "ribostamycin anabolism" EXACT [GOC:yaf]
synonym: "ribostamycin biosynthesis" EXACT [GOC:yaf]
synonym: "ribostamycin biosynthetic process" EXACT [GOC:yaf]
synonym: "ribostamycin formation" EXACT [GOC:yaf]
synonym: "ribostamycin synthesis" EXACT [GOC:yaf]
synonym: "vistamycin anabolism" EXACT [GOC:TermGenie]
synonym: "vistamycin biosynthesis" EXACT [GOC:TermGenie]
synonym: "vistamycin formation" EXACT [GOC:TermGenie]
synonym: "vistamycin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0016138 ! glycoside biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:1901150 ! vistamycin metabolic process
created_by: yaf
creation_date: 2012-07-17T04:27:15Z

[Term]
id: GO:1901153
name: paromomycin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving paromomycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00970]
synonym: "paromomycin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019751 ! polyol metabolic process
is_a: GO:0030647 ! aminoglycoside antibiotic metabolic process
created_by: yaf
creation_date: 2012-07-17T04:27:20Z

[Term]
id: GO:1901154
name: paromomycin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of paromomycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00970]
synonym: "paromomycin breakdown" EXACT [GOC:TermGenie]
synonym: "paromomycin catabolism" EXACT [GOC:TermGenie]
synonym: "paromomycin degradation" EXACT [GOC:TermGenie]
is_a: GO:0030649 ! aminoglycoside antibiotic catabolic process
is_a: GO:0046174 ! polyol catabolic process
is_a: GO:1901153 ! paromomycin metabolic process
created_by: yaf
creation_date: 2012-07-17T04:27:44Z

[Term]
id: GO:1901155
name: paromomycin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of paromomycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00970]
synonym: "paromomycin anabolism" EXACT [GOC:TermGenie]
synonym: "paromomycin biosynthesis" EXACT [GOC:TermGenie]
synonym: "paromomycin formation" EXACT [GOC:TermGenie]
synonym: "paromomycin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0030648 ! aminoglycoside antibiotic biosynthetic process
is_a: GO:0046173 ! polyol biosynthetic process
is_a: GO:1901153 ! paromomycin metabolic process
created_by: yaf
creation_date: 2012-07-17T04:27:51Z

[Term]
id: GO:1901156
name: neomycin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving neomycin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-7016, UniPathway:UPA00969]
synonym: "neomycin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019751 ! polyol metabolic process
is_a: GO:0030647 ! aminoglycoside antibiotic metabolic process
created_by: yaf
creation_date: 2012-07-17T04:27:57Z

[Term]
id: GO:1901157
name: neomycin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of neomycin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-7016, UniPathway:UPA00969]
synonym: "neomycin breakdown" EXACT [GOC:TermGenie]
synonym: "neomycin catabolism" EXACT [GOC:TermGenie]
synonym: "neomycin degradation" EXACT [GOC:TermGenie]
is_a: GO:0030649 ! aminoglycoside antibiotic catabolic process
is_a: GO:0046174 ! polyol catabolic process
is_a: GO:1901156 ! neomycin metabolic process
created_by: yaf
creation_date: 2012-07-17T04:28:20Z

[Term]
id: GO:1901158
name: neomycin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of neomycin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-7016, UniPathway:UPA00969]
synonym: "neomycin anabolism" EXACT [GOC:TermGenie]
synonym: "neomycin biosynthesis" EXACT [GOC:TermGenie]
synonym: "neomycin formation" EXACT [GOC:TermGenie]
synonym: "neomycin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0030648 ! aminoglycoside antibiotic biosynthetic process
is_a: GO:0046173 ! polyol biosynthetic process
is_a: GO:1901156 ! neomycin metabolic process
created_by: yaf
creation_date: 2012-07-17T04:28:28Z

[Term]
id: GO:1901159
name: xylulose 5-phosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of xylulose 5-phosphate." [GOC:bf, GOC:TermGenie]
synonym: "xylulose 5-phosphate anabolism" EXACT [GOC:TermGenie]
synonym: "xylulose 5-phosphate biosynthesis" EXACT [GOC:TermGenie]
synonym: "xylulose 5-phosphate formation" EXACT [GOC:TermGenie]
synonym: "xylulose 5-phosphate synthesis" EXACT [GOC:TermGenie]
is_a: GO:0051167 ! xylulose 5-phosphate metabolic process
is_a: GO:0090407 ! organophosphate biosynthetic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process
created_by: bf
creation_date: 2012-07-18T04:42:24Z

[Term]
id: GO:1901160
name: primary amino compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving primary amino compound." [GOC:TermGenie]
synonym: "primary amino compound metabolism" EXACT [GOC:TermGenie]
is_a: GO:1901564 ! organonitrogen compound metabolic process
created_by: bf
creation_date: 2012-07-18T04:44:39Z

[Term]
id: GO:1901161
name: primary amino compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of primary amino compound." [GOC:TermGenie]
synonym: "primary amino compound breakdown" EXACT [GOC:TermGenie]
synonym: "primary amino compound catabolism" EXACT [GOC:TermGenie]
synonym: "primary amino compound degradation" EXACT [GOC:TermGenie]
is_a: GO:1901160 ! primary amino compound metabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process
created_by: bf
creation_date: 2012-07-18T04:45:06Z

[Term]
id: GO:1901162
name: primary amino compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of primary amino compound." [GOC:TermGenie]
synonym: "primary amino compound anabolism" EXACT [GOC:TermGenie]
synonym: "primary amino compound biosynthesis" EXACT [GOC:TermGenie]
synonym: "primary amino compound formation" EXACT [GOC:TermGenie]
synonym: "primary amino compound synthesis" EXACT [GOC:TermGenie]
is_a: GO:1901160 ! primary amino compound metabolic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process
created_by: bf
creation_date: 2012-07-18T04:45:14Z

[Term]
id: GO:1901163
name: regulation of trophoblast cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of trophoblast cell migration." [GOC:BHF, GOC:TermGenie]
is_a: GO:0030334 ! regulation of cell migration
is_a: GO:0043900 ! regulation of multi-organism process
is_a: GO:2000026 ! regulation of multicellular organismal development
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061450 ! trophoblast cell migration
relationship: regulates GO:0061450 ! trophoblast cell migration
created_by: vk
creation_date: 2012-07-19T07:53:06Z

[Term]
id: GO:1901164
name: negative regulation of trophoblast cell migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of trophoblast cell migration." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of trophoblast cell migration" EXACT [GOC:TermGenie]
synonym: "down-regulation of trophoblast cell migration" EXACT [GOC:TermGenie]
synonym: "downregulation of trophoblast cell migration" EXACT [GOC:TermGenie]
synonym: "inhibition of trophoblast cell migration" NARROW [GOC:TermGenie]
is_a: GO:0030336 ! negative regulation of cell migration
is_a: GO:0043901 ! negative regulation of multi-organism process
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1901163 ! regulation of trophoblast cell migration
is_a: GO:2000242 ! negative regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061450 ! trophoblast cell migration
relationship: negatively_regulates GO:0061450 ! trophoblast cell migration
created_by: vk
creation_date: 2012-07-19T07:53:28Z

[Term]
id: GO:1901165
name: positive regulation of trophoblast cell migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of trophoblast cell migration." [GOC:BHF, GOC:TermGenie]
synonym: "activation of trophoblast cell migration" NARROW [GOC:TermGenie]
synonym: "up regulation of trophoblast cell migration" EXACT [GOC:TermGenie]
synonym: "up-regulation of trophoblast cell migration" EXACT [GOC:TermGenie]
synonym: "upregulation of trophoblast cell migration" EXACT [GOC:TermGenie]
is_a: GO:0030335 ! positive regulation of cell migration
is_a: GO:0043902 ! positive regulation of multi-organism process
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1901163 ! regulation of trophoblast cell migration
is_a: GO:2000243 ! positive regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061450 ! trophoblast cell migration
relationship: positively_regulates GO:0061450 ! trophoblast cell migration
created_by: vk
creation_date: 2012-07-19T07:53:35Z

[Term]
id: GO:1901166
name: neural crest cell migration involved in autonomic nervous system development
namespace: biological_process
def: "Any neural crest cell migration that is involved in autonomic nervous system development." [GOC:BHF, GOC:TermGenie]
is_a: GO:0001755 ! neural crest cell migration
intersection_of: GO:0001755 ! neural crest cell migration
intersection_of: part_of GO:0048483 ! autonomic nervous system development
relationship: part_of GO:0048483 ! autonomic nervous system development
created_by: vk
creation_date: 2012-07-19T08:39:56Z

[Term]
id: GO:1901167
name: 3-chlorocatechol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 3-chlorocatechol." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00083]
synonym: "3-chlorocatechol metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009712 ! catechol-containing compound metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process
created_by: yaf
creation_date: 2012-07-19T09:33:16Z

[Term]
id: GO:1901168
name: 3-chlorocatechol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 3-chlorocatechol." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00083]
synonym: "3-chlorocatechol breakdown" EXACT [GOC:TermGenie]
synonym: "3-chlorocatechol catabolism" EXACT [GOC:TermGenie]
synonym: "3-chlorocatechol degradation" EXACT [GOC:TermGenie]
is_a: GO:0019614 ! catechol-containing compound catabolic process
is_a: GO:1901167 ! 3-chlorocatechol metabolic process
created_by: yaf
creation_date: 2012-07-19T09:33:38Z

[Term]
id: GO:1901169
name: 3-chlorocatechol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 3-chlorocatechol." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00083]
synonym: "3-chlorocatechol anabolism" EXACT [GOC:TermGenie]
synonym: "3-chlorocatechol biosynthesis" EXACT [GOC:TermGenie]
synonym: "3-chlorocatechol formation" EXACT [GOC:TermGenie]
synonym: "3-chlorocatechol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009713 ! catechol-containing compound biosynthetic process
is_a: GO:1901167 ! 3-chlorocatechol metabolic process
created_by: yaf
creation_date: 2012-07-19T09:33:45Z

[Term]
id: GO:1901170
name: naphthalene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of naphthalene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00082]
synonym: "naphthalene breakdown" EXACT [GOC:TermGenie]
synonym: "naphthalene catabolism" EXACT [GOC:TermGenie]
synonym: "naphthalene degradation" EXACT [GOC:TermGenie]
is_a: GO:0018931 ! naphthalene metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
created_by: yaf
creation_date: 2012-07-19T09:33:50Z

[Term]
id: GO:1901171
name: naphthalene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of naphthalene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00082]
synonym: "naphthalene anabolism" EXACT [GOC:TermGenie]
synonym: "naphthalene biosynthesis" EXACT [GOC:TermGenie]
synonym: "naphthalene formation" EXACT [GOC:TermGenie]
synonym: "naphthalene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0018931 ! naphthalene metabolic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
created_by: yaf
creation_date: 2012-07-19T09:34:11Z

[Term]
id: GO:1901172
name: phytoene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phytoene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00799]
synonym: "phytoene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0016119 ! carotene metabolic process
created_by: yaf
creation_date: 2012-07-19T09:47:46Z

[Term]
id: GO:1901173
name: phytoene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phytoene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00799]
synonym: "phytoene breakdown" EXACT [GOC:TermGenie]
synonym: "phytoene catabolism" EXACT [GOC:TermGenie]
synonym: "phytoene degradation" EXACT [GOC:TermGenie]
is_a: GO:0016121 ! carotene catabolic process
is_a: GO:1901172 ! phytoene metabolic process
created_by: yaf
creation_date: 2012-07-19T09:48:07Z

[Term]
id: GO:1901174
name: phytoene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phytoene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00799]
synonym: "phytoene anabolism" EXACT [GOC:TermGenie]
synonym: "phytoene biosynthesis" EXACT [GOC:TermGenie]
synonym: "phytoene formation" EXACT [GOC:TermGenie]
synonym: "phytoene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0016120 ! carotene biosynthetic process
is_a: GO:1901172 ! phytoene metabolic process
created_by: yaf
creation_date: 2012-07-19T09:48:15Z

[Term]
id: GO:1901175
name: lycopene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lycopene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00803]
synonym: "lycopene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0016119 ! carotene metabolic process
created_by: yaf
creation_date: 2012-07-19T09:48:20Z

[Term]
id: GO:1901176
name: lycopene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lycopene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00803]
synonym: "lycopene breakdown" EXACT [GOC:TermGenie]
synonym: "lycopene catabolism" EXACT [GOC:TermGenie]
synonym: "lycopene degradation" EXACT [GOC:TermGenie]
is_a: GO:0016121 ! carotene catabolic process
is_a: GO:1901175 ! lycopene metabolic process
created_by: yaf
creation_date: 2012-07-19T09:48:41Z

[Term]
id: GO:1901177
name: lycopene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lycopene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00803]
synonym: "lycopene anabolism" EXACT [GOC:TermGenie]
synonym: "lycopene biosynthesis" EXACT [GOC:TermGenie]
synonym: "lycopene formation" EXACT [GOC:TermGenie]
synonym: "lycopene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0016120 ! carotene biosynthetic process
is_a: GO:1901175 ! lycopene metabolic process
created_by: yaf
creation_date: 2012-07-19T09:48:49Z

[Term]
id: GO:1901178
name: spheroidene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving spheroidene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00683]
synonym: "spheroidene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0016122 ! xanthophyll metabolic process
is_a: GO:0018904 ! ether metabolic process
created_by: yaf
creation_date: 2012-07-19T09:48:54Z

[Term]
id: GO:1901179
name: spheroidene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of spheroidene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00683]
synonym: "spheroidene breakdown" EXACT [GOC:TermGenie]
synonym: "spheroidene catabolism" EXACT [GOC:TermGenie]
synonym: "spheroidene degradation" EXACT [GOC:TermGenie]
is_a: GO:0016124 ! xanthophyll catabolic process
is_a: GO:1901178 ! spheroidene metabolic process
is_a: GO:1901502 ! ether catabolic process
created_by: yaf
creation_date: 2012-07-19T09:49:14Z

[Term]
id: GO:1901180
name: spheroidene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of spheroidene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00683]
synonym: "spheroidene anabolism" EXACT [GOC:TermGenie]
synonym: "spheroidene biosynthesis" EXACT [GOC:TermGenie]
synonym: "spheroidene formation" EXACT [GOC:TermGenie]
synonym: "spheroidene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0016123 ! xanthophyll biosynthetic process
is_a: GO:1901178 ! spheroidene metabolic process
is_a: GO:1901503 ! ether biosynthetic process
created_by: yaf
creation_date: 2012-07-19T09:49:22Z

[Term]
id: GO:1901181
name: negative regulation of cellular response to caffeine
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to caffeine." [GOC:TermGenie]
synonym: "down regulation of cellular response to caffeine" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular response to caffeine" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular response to caffeine" EXACT [GOC:TermGenie]
synonym: "inhibition of cellular response to caffeine" NARROW [GOC:TermGenie]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0048585 ! negative regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071313 ! cellular response to caffeine
relationship: negatively_regulates GO:0071313 ! cellular response to caffeine
created_by: al
creation_date: 2012-07-19T04:11:46Z

[Term]
id: GO:1901182
name: regulation of camalexin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of camalexin biosynthetic process." [GOC:TermGenie]
synonym: "regulation of camalexin anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of camalexin biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of camalexin formation" EXACT [GOC:TermGenie]
synonym: "regulation of camalexin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0042762 ! regulation of sulfur metabolic process
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
is_a: GO:0052319 ! regulation of phytoalexin biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010120 ! camalexin biosynthetic process
relationship: regulates GO:0010120 ! camalexin biosynthetic process
created_by: tb
creation_date: 2012-07-23T02:16:52Z

[Term]
id: GO:1901183
name: positive regulation of camalexin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of camalexin biosynthetic process." [GOC:TermGenie]
synonym: "activation of camalexin anabolism" EXACT [GOC:TermGenie]
synonym: "activation of camalexin biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of camalexin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of camalexin formation" EXACT [GOC:TermGenie]
synonym: "activation of camalexin synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of camalexin anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of camalexin biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of camalexin formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of camalexin synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of camalexin anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of camalexin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of camalexin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of camalexin formation" EXACT [GOC:TermGenie]
synonym: "up regulation of camalexin synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of camalexin anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of camalexin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of camalexin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of camalexin formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of camalexin synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of camalexin anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of camalexin biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of camalexin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of camalexin formation" EXACT [GOC:TermGenie]
synonym: "upregulation of camalexin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process
is_a: GO:0051176 ! positive regulation of sulfur metabolic process
is_a: GO:0052322 ! positive regulation of phytoalexin biosynthetic process
is_a: GO:1901182 ! regulation of camalexin biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010120 ! camalexin biosynthetic process
relationship: positively_regulates GO:0010120 ! camalexin biosynthetic process
created_by: tb
creation_date: 2012-07-23T02:17:21Z

[Term]
id: GO:1901184
name: regulation of ERBB signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ERBB signaling pathway." [GOC:BHF, GOC:TermGenie]
synonym: "regulation of EGF receptor family signaling pathway" EXACT [GOC:TermGenie]
synonym: "regulation of EGFR family signaling pathway" RELATED [GOC:TermGenie]
synonym: "regulation of ErbB signaling" EXACT [GOC:TermGenie]
synonym: "regulation of ERBB signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0009966 ! regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0038127 ! ERBB signaling pathway
relationship: regulates GO:0038127 ! ERBB signaling pathway
created_by: rl
creation_date: 2012-07-24T07:37:11Z

[Term]
id: GO:1901185
name: negative regulation of ERBB signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ERBB signaling pathway." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of EGF receptor family signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of EGFR family signaling pathway" RELATED [GOC:TermGenie]
synonym: "down regulation of ErbB signaling" EXACT [GOC:TermGenie]
synonym: "down regulation of ERBB signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of ERBB signalling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of EGF receptor family signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of EGFR family signaling pathway" RELATED [GOC:TermGenie]
synonym: "down-regulation of ErbB signaling" EXACT [GOC:TermGenie]
synonym: "down-regulation of ERBB signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of ERBB signalling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of EGF receptor family signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of EGFR family signaling pathway" RELATED [GOC:TermGenie]
synonym: "downregulation of ErbB signaling" EXACT [GOC:TermGenie]
synonym: "downregulation of ERBB signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of ERBB signalling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of EGF receptor family signaling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of EGFR family signaling pathway" RELATED [GOC:TermGenie]
synonym: "inhibition of ErbB signaling" EXACT [GOC:TermGenie]
synonym: "inhibition of ERBB signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of ERBB signalling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of EGF receptor family signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of EGFR family signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of ErbB signaling" EXACT [GOC:TermGenie]
synonym: "negative regulation of ERBB signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:1901184 ! regulation of ERBB signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0038127 ! ERBB signaling pathway
relationship: negatively_regulates GO:0038127 ! ERBB signaling pathway
created_by: rl
creation_date: 2012-07-24T07:37:35Z

[Term]
id: GO:1901186
name: positive regulation of ERBB signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ERBB signaling pathway." [GOC:BHF, GOC:TermGenie]
synonym: "activation of EGF receptor family signaling pathway" EXACT [GOC:TermGenie]
synonym: "activation of EGFR family signaling pathway" RELATED [GOC:TermGenie]
synonym: "activation of ErbB signaling" EXACT [GOC:TermGenie]
synonym: "activation of ERBB signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of ERBB signalling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of EGF receptor family signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of EGFR family signaling pathway" RELATED [GOC:TermGenie]
synonym: "positive regulation of ErbB signaling" EXACT [GOC:TermGenie]
synonym: "positive regulation of ERBB signalling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of EGF receptor family signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of EGFR family signaling pathway" RELATED [GOC:TermGenie]
synonym: "up regulation of ErbB signaling" EXACT [GOC:TermGenie]
synonym: "up regulation of ERBB signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of ERBB signalling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of EGF receptor family signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of EGFR family signaling pathway" RELATED [GOC:TermGenie]
synonym: "up-regulation of ErbB signaling" EXACT [GOC:TermGenie]
synonym: "up-regulation of ERBB signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of ERBB signalling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of EGF receptor family signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of EGFR family signaling pathway" RELATED [GOC:TermGenie]
synonym: "upregulation of ErbB signaling" EXACT [GOC:TermGenie]
synonym: "upregulation of ERBB signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of ERBB signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:1901184 ! regulation of ERBB signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0038127 ! ERBB signaling pathway
relationship: positively_regulates GO:0038127 ! ERBB signaling pathway
created_by: rl
creation_date: 2012-07-24T07:37:43Z

[Term]
id: GO:1901187
name: regulation of ephrin receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ephrin receptor signaling pathway." [GOC:BHF, GOC:TermGenie]
synonym: "regulation of Eph receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "regulation of Eph receptor signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0009966 ! regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048013 ! ephrin receptor signaling pathway
relationship: regulates GO:0048013 ! ephrin receptor signaling pathway
created_by: rl
creation_date: 2012-07-24T07:41:49Z

[Term]
id: GO:1901188
name: negative regulation of ephrin receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ephrin receptor signaling pathway." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of Eph receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of Eph receptor signalling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of ephrin receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of Eph receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of Eph receptor signalling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of ephrin receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of Eph receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of Eph receptor signalling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of ephrin receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of Eph receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of Eph receptor signalling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of ephrin receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of Eph receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of Eph receptor signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:1901187 ! regulation of ephrin receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048013 ! ephrin receptor signaling pathway
relationship: negatively_regulates GO:0048013 ! ephrin receptor signaling pathway
created_by: rl
creation_date: 2012-07-24T07:42:14Z

[Term]
id: GO:1901189
name: positive regulation of ephrin receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ephrin receptor signaling pathway." [GOC:BHF, GOC:TermGenie]
synonym: "activation of Eph receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "activation of Eph receptor signalling pathway" EXACT [GOC:TermGenie]
synonym: "activation of ephrin receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of Eph receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of Eph receptor signalling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of Eph receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of Eph receptor signalling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of ephrin receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of Eph receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of Eph receptor signalling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of ephrin receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of Eph receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of Eph receptor signalling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of ephrin receptor signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:1901187 ! regulation of ephrin receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048013 ! ephrin receptor signaling pathway
relationship: positively_regulates GO:0048013 ! ephrin receptor signaling pathway
created_by: rl
creation_date: 2012-07-24T07:42:21Z

[Term]
id: GO:1901190
name: regulation of formation of translation initiation ternary complex
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of formation of translation initiation ternary complex." [GOC:TermGenie]
synonym: "regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie]
is_a: GO:0006446 ! regulation of translational initiation
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001677 ! formation of translation initiation ternary complex
relationship: regulates GO:0001677 ! formation of translation initiation ternary complex
created_by: ss
creation_date: 2012-07-25T02:26:58Z

[Term]
id: GO:1901191
name: negative regulation of formation of translation initiation ternary complex
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of formation of translation initiation ternary complex." [GOC:TermGenie]
synonym: "down regulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie]
synonym: "down regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie]
synonym: "down-regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie]
synonym: "downregulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of formation of translation initiation ternary complex" NARROW [GOC:TermGenie]
synonym: "inhibition of translation initiation ternary complex assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie]
is_a: GO:0045947 ! negative regulation of translational initiation
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1901190 ! regulation of formation of translation initiation ternary complex
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001677 ! formation of translation initiation ternary complex
relationship: negatively_regulates GO:0001677 ! formation of translation initiation ternary complex
created_by: ss
creation_date: 2012-07-25T02:27:21Z

[Term]
id: GO:1901192
name: positive regulation of formation of translation initiation ternary complex
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of formation of translation initiation ternary complex." [GOC:TermGenie]
synonym: "activation of formation of translation initiation ternary complex" NARROW [GOC:TermGenie]
synonym: "activation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie]
synonym: "up regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie]
synonym: "up-regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie]
synonym: "upregulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie]
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:0045948 ! positive regulation of translational initiation
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1901190 ! regulation of formation of translation initiation ternary complex
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001677 ! formation of translation initiation ternary complex
relationship: positively_regulates GO:0001677 ! formation of translation initiation ternary complex
created_by: ss
creation_date: 2012-07-25T02:27:29Z

[Term]
id: GO:1901193
name: regulation of formation of translation preinitiation complex
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of formation of translation preinitiation complex." [GOC:TermGenie]
synonym: "regulation of formation of translation pre-initiation complex" EXACT [GOC:TermGenie]
synonym: "regulation of translation preinitiation complex assembly" EXACT [GOC:TermGenie]
is_a: GO:0006446 ! regulation of translational initiation
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001731 ! formation of translation preinitiation complex
relationship: regulates GO:0001731 ! formation of translation preinitiation complex
created_by: ss
creation_date: 2012-07-25T02:31:20Z

[Term]
id: GO:1901194
name: negative regulation of formation of translation preinitiation complex
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of formation of translation preinitiation complex." [GOC:TermGenie]
synonym: "down regulation of formation of translation pre-initiation complex" EXACT [GOC:TermGenie]
synonym: "down regulation of formation of translation preinitiation complex" EXACT [GOC:TermGenie]
synonym: "down regulation of translation preinitiation complex assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of formation of translation pre-initiation complex" EXACT [GOC:TermGenie]
synonym: "down-regulation of formation of translation preinitiation complex" EXACT [GOC:TermGenie]
synonym: "down-regulation of translation preinitiation complex assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of formation of translation pre-initiation complex" EXACT [GOC:TermGenie]
synonym: "downregulation of formation of translation preinitiation complex" EXACT [GOC:TermGenie]
synonym: "downregulation of translation preinitiation complex assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of formation of translation pre-initiation complex" EXACT [GOC:TermGenie]
synonym: "inhibition of formation of translation preinitiation complex" NARROW [GOC:TermGenie]
synonym: "inhibition of translation preinitiation complex assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of formation of translation pre-initiation complex" EXACT [GOC:TermGenie]
synonym: "negative regulation of translation preinitiation complex assembly" EXACT [GOC:TermGenie]
is_a: GO:0045947 ! negative regulation of translational initiation
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1901193 ! regulation of formation of translation preinitiation complex
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001731 ! formation of translation preinitiation complex
relationship: negatively_regulates GO:0001731 ! formation of translation preinitiation complex
created_by: ss
creation_date: 2012-07-25T02:31:41Z

[Term]
id: GO:1901195
name: positive regulation of formation of translation preinitiation complex
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of formation of translation preinitiation complex." [GOC:TermGenie]
synonym: "activation of formation of translation pre-initiation complex" EXACT [GOC:TermGenie]
synonym: "activation of formation of translation preinitiation complex" NARROW [GOC:TermGenie]
synonym: "activation of translation preinitiation complex assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of formation of translation pre-initiation complex" EXACT [GOC:TermGenie]
synonym: "positive regulation of translation preinitiation complex assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of formation of translation pre-initiation complex" EXACT [GOC:TermGenie]
synonym: "up regulation of formation of translation preinitiation complex" EXACT [GOC:TermGenie]
synonym: "up regulation of translation preinitiation complex assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of formation of translation pre-initiation complex" EXACT [GOC:TermGenie]
synonym: "up-regulation of formation of translation preinitiation complex" EXACT [GOC:TermGenie]
synonym: "up-regulation of translation preinitiation complex assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of formation of translation pre-initiation complex" EXACT [GOC:TermGenie]
synonym: "upregulation of formation of translation preinitiation complex" EXACT [GOC:TermGenie]
synonym: "upregulation of translation preinitiation complex assembly" EXACT [GOC:TermGenie]
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:0045948 ! positive regulation of translational initiation
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1901193 ! regulation of formation of translation preinitiation complex
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001731 ! formation of translation preinitiation complex
relationship: positively_regulates GO:0001731 ! formation of translation preinitiation complex
created_by: ss
creation_date: 2012-07-25T02:31:50Z

[Term]
id: GO:1901196
name: positive regulation of calcium-mediated signaling involved in cellular response to salt stress
namespace: biological_process
def: "Any positive regulation of calcium-mediated signaling that is involved in cellular response to salt stress." [GOC:TermGenie]
synonym: "activation of calcium-mediated signaling involved in cellular response to ionic osmotic stress" NARROW [GOC:TermGenie]
synonym: "activation of calcium-mediated signaling involved in cellular response to salt stress" NARROW [GOC:TermGenie]
synonym: "activation of calcium-mediated signaling involved in cellular salinity response" NARROW [GOC:TermGenie]
synonym: "positive regulation of calcium-mediated signaling involved in cellular response to ionic osmotic stress" EXACT [GOC:TermGenie]
synonym: "positive regulation of calcium-mediated signaling involved in cellular salinity response" EXACT [GOC:TermGenie]
synonym: "positive regulation of calcium-mediated signalling involved in cellular response to ionic osmotic stress" EXACT [GOC:TermGenie]
synonym: "positive regulation of calcium-mediated signalling involved in cellular response to salt stress" EXACT [GOC:TermGenie]
synonym: "positive regulation of calcium-mediated signalling involved in cellular salinity response" EXACT [GOC:TermGenie]
synonym: "stimulation of calcium-mediated signaling involved in cellular response to ionic osmotic stress" NARROW [GOC:TermGenie]
synonym: "stimulation of calcium-mediated signaling involved in cellular response to salt stress" NARROW [GOC:TermGenie]
synonym: "stimulation of calcium-mediated signaling involved in cellular salinity response" NARROW [GOC:TermGenie]
synonym: "up regulation of calcium-mediated signaling involved in cellular response to ionic osmotic stress" EXACT [GOC:TermGenie]
synonym: "up regulation of calcium-mediated signaling involved in cellular response to salt stress" EXACT [GOC:TermGenie]
synonym: "up regulation of calcium-mediated signaling involved in cellular salinity response" EXACT [GOC:TermGenie]
synonym: "up-regulation of calcium-mediated signaling involved in cellular response to ionic osmotic stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of calcium-mediated signaling involved in cellular response to salt stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of calcium-mediated signaling involved in cellular salinity response" EXACT [GOC:TermGenie]
synonym: "upregulation of calcium-mediated signaling involved in cellular response to ionic osmotic stress" EXACT [GOC:TermGenie]
synonym: "upregulation of calcium-mediated signaling involved in cellular response to salt stress" EXACT [GOC:TermGenie]
synonym: "upregulation of calcium-mediated signaling involved in cellular salinity response" EXACT [GOC:TermGenie]
is_a: GO:0050850 ! positive regulation of calcium-mediated signaling
intersection_of: GO:0050850 ! positive regulation of calcium-mediated signaling
intersection_of: part_of GO:0071472 ! cellular response to salt stress
relationship: part_of GO:0071472 ! cellular response to salt stress
created_by: al
creation_date: 2012-07-27T10:52:56Z

[Term]
id: GO:1901197
name: positive regulation of calcium-mediated signaling involved in cellular response to calcium ion
namespace: biological_process
def: "Any positive regulation of calcium-mediated signaling that is involved in cellular response to calcium ion." [GOC:TermGenie]
synonym: "activation of calcium-mediated signaling involved in cellular response to Ca2+ ion" NARROW [GOC:TermGenie]
synonym: "activation of calcium-mediated signaling involved in cellular response to calcium ion" NARROW [GOC:TermGenie]
synonym: "positive regulation of calcium-mediated signaling involved in cellular response to Ca2+ ion" EXACT [GOC:TermGenie]
synonym: "positive regulation of calcium-mediated signalling involved in cellular response to Ca2+ ion" EXACT [GOC:TermGenie]
synonym: "positive regulation of calcium-mediated signalling involved in cellular response to calcium ion" EXACT [GOC:TermGenie]
synonym: "stimulation of calcium-mediated signaling involved in cellular response to Ca2+ ion" NARROW [GOC:TermGenie]
synonym: "stimulation of calcium-mediated signaling involved in cellular response to calcium ion" NARROW [GOC:TermGenie]
synonym: "up regulation of calcium-mediated signaling involved in cellular response to Ca2+ ion" EXACT [GOC:TermGenie]
synonym: "up regulation of calcium-mediated signaling involved in cellular response to calcium ion" EXACT [GOC:TermGenie]
synonym: "up-regulation of calcium-mediated signaling involved in cellular response to Ca2+ ion" EXACT [GOC:TermGenie]
synonym: "up-regulation of calcium-mediated signaling involved in response to calcium ion" EXACT [GOC:TermGenie]
synonym: "upregulation of calcium-mediated signaling involved in cellular response to Ca2+ ion" EXACT [GOC:TermGenie]
synonym: "upregulation of calcium-mediated signaling involved in cellular response to calcium ion" EXACT [GOC:TermGenie]
is_a: GO:0050850 ! positive regulation of calcium-mediated signaling
intersection_of: GO:0050850 ! positive regulation of calcium-mediated signaling
intersection_of: part_of GO:0071277 ! cellular response to calcium ion
relationship: part_of GO:0071277 ! cellular response to calcium ion
created_by: al
creation_date: 2012-07-27T10:57:56Z

[Term]
id: GO:1901198
name: positive regulation of calcium ion transport into cytosol involved in cellular response to calcium ion
namespace: biological_process
def: "Any positive regulation of calcium ion transport into cytosol that is involved in cellular response to calcium ion." [GOC:TermGenie]
synonym: "positive regulation of calcium ion transport into cytosol involved in cellular response to Ca2+ ion" EXACT [GOC:TermGenie]
is_a: GO:0010524 ! positive regulation of calcium ion transport into cytosol
intersection_of: GO:0010524 ! positive regulation of calcium ion transport into cytosol
intersection_of: part_of GO:0071277 ! cellular response to calcium ion
relationship: part_of GO:0071277 ! cellular response to calcium ion
created_by: al
creation_date: 2012-07-27T11:07:43Z

[Term]
id: GO:1901199
name: positive regulation of calcium ion transport into cytosol involved in cellular response to salt stress
namespace: biological_process
def: "Any positive regulation of calcium ion transport into cytosol that is involved in cellular response to salt stress." [GOC:TermGenie]
synonym: "positive regulation of calcium ion transport into cytosol involved in cellular response to ionic osmotic stress" EXACT [GOC:TermGenie]
synonym: "positive regulation of calcium ion transport into cytosol involved in cellular salinity response" EXACT [GOC:TermGenie]
is_a: GO:0010524 ! positive regulation of calcium ion transport into cytosol
intersection_of: GO:0010524 ! positive regulation of calcium ion transport into cytosol
intersection_of: part_of GO:0071472 ! cellular response to salt stress
relationship: part_of GO:0071472 ! cellular response to salt stress
created_by: al
creation_date: 2012-07-27T11:09:37Z

[Term]
id: GO:1901200
name: negative regulation of calcium ion transport into cytosol involved in cellular response to salt stress
namespace: biological_process
def: "Any negative regulation of calcium ion transport into cytosol that is involved in cellular response to salt stress." [GOC:TermGenie]
synonym: "negative regulation of calcium ion transport into cytosol involved in cellular response to ionic osmotic stress" EXACT [GOC:TermGenie]
synonym: "negative regulation of calcium ion transport into cytosol involved in cellular salinity response" EXACT [GOC:TermGenie]
is_a: GO:0010523 ! negative regulation of calcium ion transport into cytosol
intersection_of: GO:0010523 ! negative regulation of calcium ion transport into cytosol
intersection_of: part_of GO:0071472 ! cellular response to salt stress
relationship: part_of GO:0071472 ! cellular response to salt stress
created_by: al
creation_date: 2012-07-27T11:11:09Z

[Term]
id: GO:1901201
name: regulation of extracellular matrix assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of extracellular matrix assembly." [GOC:BHF, GOC:TermGenie]
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:1903053 ! regulation of extracellular matrix organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0085029 ! extracellular matrix assembly
relationship: regulates GO:0085029 ! extracellular matrix assembly
created_by: rl
creation_date: 2012-07-27T04:04:00Z

[Term]
id: GO:1901202
name: negative regulation of extracellular matrix assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix assembly." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of extracellular matrix assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of extracellular matrix assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of extracellular matrix assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of extracellular matrix assembly" NARROW [GOC:TermGenie]
is_a: GO:1901201 ! regulation of extracellular matrix assembly
is_a: GO:1903054 ! negative regulation of extracellular matrix organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0085029 ! extracellular matrix assembly
relationship: negatively_regulates GO:0085029 ! extracellular matrix assembly
created_by: rl
creation_date: 2012-07-27T04:04:24Z

[Term]
id: GO:1901203
name: positive regulation of extracellular matrix assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of extracellular matrix assembly." [GOC:BHF, GOC:TermGenie]
synonym: "activation of extracellular matrix assembly" NARROW [GOC:TermGenie]
synonym: "up regulation of extracellular matrix assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of extracellular matrix assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of extracellular matrix assembly" EXACT [GOC:TermGenie]
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:1901201 ! regulation of extracellular matrix assembly
is_a: GO:1903055 ! positive regulation of extracellular matrix organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0085029 ! extracellular matrix assembly
relationship: positively_regulates GO:0085029 ! extracellular matrix assembly
created_by: rl
creation_date: 2012-07-27T04:04:32Z

[Term]
id: GO:1901204
name: regulation of adrenergic receptor signaling pathway involved in heart process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a cardiac adrenergic receptor signaling pathway." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie]
synonym: "regulation of adrenergic receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "regulation of beta-adrenergic receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie]
is_a: GO:0044057 ! regulation of system process
is_a: GO:0071877 ! regulation of adrenergic receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0086023 ! adrenergic receptor signaling pathway involved in heart process
relationship: regulates GO:0086023 ! adrenergic receptor signaling pathway involved in heart process
created_by: hjd
creation_date: 2012-07-30T18:32:51Z

[Term]
id: GO:1901205
name: negative regulation of adrenergic receptor signaling pathway involved in heart process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of a cardiac adrenergic receptor signaling pathway." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie]
synonym: "down regulation of adrenergic receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "down regulation of adrenergic receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "down regulation of beta-adrenergic receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie]
synonym: "down-regulation of adrenergic receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "down-regulation of adrenergic receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "down-regulation of beta-adrenergic receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie]
synonym: "downregulation of adrenergic receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "downregulation of adrenergic receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "downregulation of beta-adrenergic receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie]
synonym: "inhibition of adrenergic receptor signaling pathway involved in heart process" NARROW [GOC:TermGenie]
synonym: "inhibition of adrenergic receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "inhibition of beta-adrenergic receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie]
synonym: "negative regulation of adrenergic receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "negative regulation of beta-adrenergic receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie]
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0071878 ! negative regulation of adrenergic receptor signaling pathway
is_a: GO:1901204 ! regulation of adrenergic receptor signaling pathway involved in heart process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0086023 ! adrenergic receptor signaling pathway involved in heart process
relationship: negatively_regulates GO:0086023 ! adrenergic receptor signaling pathway involved in heart process
created_by: hjd
creation_date: 2012-07-30T18:33:14Z

[Term]
id: GO:1901206
name: positive regulation of adrenergic receptor signaling pathway involved in heart process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a cardiac adrenergic receptor signaling pathway." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie]
synonym: "activation of adrenergic receptor signaling pathway involved in heart process" NARROW [GOC:TermGenie]
synonym: "activation of adrenergic receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "activation of beta-adrenergic receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie]
synonym: "positive regulation of adrenergic receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "positive regulation of beta-adrenergic receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie]
synonym: "up regulation of adrenergic receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "up regulation of adrenergic receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "up regulation of beta-adrenergic receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie]
synonym: "up-regulation of adrenergic receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "up-regulation of adrenergic receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "up-regulation of beta-adrenergic receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie]
synonym: "upregulation of adrenergic receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "upregulation of adrenergic receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie]
synonym: "upregulation of beta-adrenergic receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie]
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0071879 ! positive regulation of adrenergic receptor signaling pathway
is_a: GO:1901204 ! regulation of adrenergic receptor signaling pathway involved in heart process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0086023 ! adrenergic receptor signaling pathway involved in heart process
relationship: positively_regulates GO:0086023 ! adrenergic receptor signaling pathway involved in heart process
created_by: hjd
creation_date: 2012-07-30T18:33:22Z

[Term]
id: GO:1901207
name: regulation of heart looping
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of heart looping." [GOC:BHF, GOC:TermGenie]
synonym: "regulation of cardiac looping" EXACT [GOC:TermGenie]
is_a: GO:0045995 ! regulation of embryonic development
is_a: GO:2000826 ! regulation of heart morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001947 ! heart looping
relationship: regulates GO:0001947 ! heart looping
created_by: rl
creation_date: 2012-07-31T07:15:47Z

[Term]
id: GO:1901208
name: negative regulation of heart looping
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of heart looping." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of cardiac looping" EXACT [GOC:TermGenie]
synonym: "down regulation of heart looping" EXACT [GOC:TermGenie]
synonym: "down-regulation of cardiac looping" EXACT [GOC:TermGenie]
synonym: "down-regulation of heart looping" EXACT [GOC:TermGenie]
synonym: "downregulation of cardiac looping" EXACT [GOC:TermGenie]
synonym: "downregulation of heart looping" EXACT [GOC:TermGenie]
synonym: "inhibition of cardiac looping" EXACT [GOC:TermGenie]
synonym: "inhibition of heart looping" NARROW [GOC:TermGenie]
synonym: "negative regulation of cardiac looping" EXACT [GOC:TermGenie]
is_a: GO:0045992 ! negative regulation of embryonic development
is_a: GO:1901207 ! regulation of heart looping
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001947 ! heart looping
relationship: negatively_regulates GO:0001947 ! heart looping
created_by: rl
creation_date: 2012-07-31T07:16:10Z

[Term]
id: GO:1901209
name: positive regulation of heart looping
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of heart looping." [GOC:BHF, GOC:TermGenie]
synonym: "activation of cardiac looping" EXACT [GOC:TermGenie]
synonym: "activation of heart looping" NARROW [GOC:TermGenie]
synonym: "positive regulation of cardiac looping" EXACT [GOC:TermGenie]
synonym: "up regulation of cardiac looping" EXACT [GOC:TermGenie]
synonym: "up regulation of heart looping" EXACT [GOC:TermGenie]
synonym: "up-regulation of cardiac looping" EXACT [GOC:TermGenie]
synonym: "up-regulation of heart looping" EXACT [GOC:TermGenie]
synonym: "upregulation of cardiac looping" EXACT [GOC:TermGenie]
synonym: "upregulation of heart looping" EXACT [GOC:TermGenie]
is_a: GO:0040019 ! positive regulation of embryonic development
is_a: GO:1901207 ! regulation of heart looping
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001947 ! heart looping
relationship: positively_regulates GO:0001947 ! heart looping
created_by: rl
creation_date: 2012-07-31T07:16:18Z

[Term]
id: GO:1901210
name: regulation of cardiac chamber formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac chamber formation." [GOC:BHF, GOC:TermGenie]
synonym: "regulation of heart chamber formation" EXACT [GOC:TermGenie]
is_a: GO:1901219 ! regulation of cardiac chamber morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003207 ! cardiac chamber formation
relationship: regulates GO:0003207 ! cardiac chamber formation
created_by: rl
creation_date: 2012-07-31T07:18:35Z

[Term]
id: GO:1901211
name: negative regulation of cardiac chamber formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac chamber formation." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of cardiac chamber formation" EXACT [GOC:TermGenie]
synonym: "down regulation of heart chamber formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of cardiac chamber formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of heart chamber formation" EXACT [GOC:TermGenie]
synonym: "downregulation of cardiac chamber formation" EXACT [GOC:TermGenie]
synonym: "downregulation of heart chamber formation" EXACT [GOC:TermGenie]
synonym: "inhibition of cardiac chamber formation" NARROW [GOC:TermGenie]
synonym: "inhibition of heart chamber formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of heart chamber formation" EXACT [GOC:TermGenie]
is_a: GO:1901210 ! regulation of cardiac chamber formation
is_a: GO:1901220 ! negative regulation of cardiac chamber morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003207 ! cardiac chamber formation
relationship: negatively_regulates GO:0003207 ! cardiac chamber formation
created_by: rl
creation_date: 2012-07-31T07:18:57Z

[Term]
id: GO:1901212
name: positive regulation of cardiac chamber formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiac chamber formation." [GOC:BHF, GOC:TermGenie]
synonym: "activation of cardiac chamber formation" NARROW [GOC:TermGenie]
synonym: "activation of heart chamber formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of heart chamber formation" EXACT [GOC:TermGenie]
synonym: "up regulation of cardiac chamber formation" EXACT [GOC:TermGenie]
synonym: "up regulation of heart chamber formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of cardiac chamber formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of heart chamber formation" EXACT [GOC:TermGenie]
synonym: "upregulation of cardiac chamber formation" EXACT [GOC:TermGenie]
synonym: "upregulation of heart chamber formation" EXACT [GOC:TermGenie]
is_a: GO:1901210 ! regulation of cardiac chamber formation
is_a: GO:1901221 ! positive regulation of cardiac chamber morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003207 ! cardiac chamber formation
relationship: positively_regulates GO:0003207 ! cardiac chamber formation
created_by: rl
creation_date: 2012-07-31T07:19:05Z

[Term]
id: GO:1901213
name: regulation of transcription from RNA polymerase II promoter involved in heart development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the development of the heart over time." [GOC:BHF, GOC:TermGenie]
synonym: "global transcription regulation from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "global transcription regulation from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "global transcription regulation from Pol II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter, global involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter, global involved in heart development" RELATED [GOC:TermGenie]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
intersection_of: part_of GO:0007507 ! heart development
relationship: part_of GO:0007507 ! heart development
created_by: rl
creation_date: 2012-07-31T07:26:45Z

[Term]
id: GO:1901214
name: regulation of neuron death
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neuron death." [GOC:rph, GOC:TermGenie]
synonym: "regulation of neuron cell death" EXACT [GOC:TermGenie]
synonym: "regulation of neuronal cell death" EXACT [GOC:TermGenie]
is_a: GO:0010941 ! regulation of cell death
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070997 ! neuron death
relationship: regulates GO:0070997 ! neuron death
created_by: rph
creation_date: 2012-08-02T09:57:41Z

[Term]
id: GO:1901215
name: negative regulation of neuron death
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuron death." [GOC:rph, GOC:TermGenie]
synonym: "down regulation of neuron cell death" EXACT [GOC:TermGenie]
synonym: "down regulation of neuron death" EXACT [GOC:TermGenie]
synonym: "down regulation of neuronal cell death" EXACT [GOC:TermGenie]
synonym: "down-regulation of neuron cell death" EXACT [GOC:TermGenie]
synonym: "down-regulation of neuron death" EXACT [GOC:TermGenie]
synonym: "down-regulation of neuronal cell death" EXACT [GOC:TermGenie]
synonym: "downregulation of neuron cell death" EXACT [GOC:TermGenie]
synonym: "downregulation of neuron death" EXACT [GOC:TermGenie]
synonym: "downregulation of neuronal cell death" EXACT [GOC:TermGenie]
synonym: "inhibition of neuron cell death" NARROW [GOC:TermGenie]
synonym: "inhibition of neuron death" NARROW [GOC:TermGenie]
synonym: "inhibition of neuronal cell death" NARROW [GOC:TermGenie]
synonym: "negative regulation of neuron cell death" EXACT [GOC:TermGenie]
synonym: "negative regulation of neuronal cell death" EXACT [GOC:TermGenie]
is_a: GO:0060548 ! negative regulation of cell death
is_a: GO:1901214 ! regulation of neuron death
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070997 ! neuron death
relationship: negatively_regulates GO:0070997 ! neuron death
created_by: rph
creation_date: 2012-08-02T09:58:07Z

[Term]
id: GO:1901216
name: positive regulation of neuron death
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neuron death." [GOC:rph, GOC:TermGenie]
synonym: "activation of neuron cell death" NARROW [GOC:TermGenie]
synonym: "activation of neuron death" NARROW [GOC:TermGenie]
synonym: "activation of neuronal cell death" NARROW [GOC:TermGenie]
synonym: "positive regulation of neuron cell death" EXACT [GOC:TermGenie]
synonym: "positive regulation of neuronal cell death" EXACT [GOC:TermGenie]
synonym: "up regulation of neuron cell death" EXACT [GOC:TermGenie]
synonym: "up regulation of neuron death" EXACT [GOC:TermGenie]
synonym: "up regulation of neuronal cell death" EXACT [GOC:TermGenie]
synonym: "up-regulation of neuron cell death" EXACT [GOC:TermGenie]
synonym: "up-regulation of neuron death" EXACT [GOC:TermGenie]
synonym: "up-regulation of neuronal cell death" EXACT [GOC:TermGenie]
synonym: "upregulation of neuron cell death" EXACT [GOC:TermGenie]
synonym: "upregulation of neuron death" EXACT [GOC:TermGenie]
synonym: "upregulation of neuronal cell death" EXACT [GOC:TermGenie]
is_a: GO:0010942 ! positive regulation of cell death
is_a: GO:1901214 ! regulation of neuron death
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070997 ! neuron death
relationship: positively_regulates GO:0070997 ! neuron death
created_by: rph
creation_date: 2012-08-02T09:58:15Z

[Term]
id: GO:1901217
name: regulation of holin activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of holin activity." [GOC:bm, GOC:TermGenie]
is_a: GO:0001898 ! regulation of cytolysis by symbiont of host cells
is_a: GO:0022898 ! regulation of transmembrane transporter activity
is_a: GO:1902186 ! regulation of viral release from host cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034290 ! holin activity
relationship: regulates GO:0034290 ! holin activity
created_by: bf
creation_date: 2012-08-06T10:47:38Z

[Term]
id: GO:1901218
name: negative regulation of holin activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of holin activity." [GOC:bm, GOC:TermGenie]
synonym: "antiholin activity" EXACT []
synonym: "down regulation of holin activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of holin activity" EXACT [GOC:TermGenie]
synonym: "downregulation of holin activity" EXACT [GOC:TermGenie]
synonym: "inhibition of holin activity" NARROW [GOC:TermGenie]
synonym: "phage antiholin" NARROW [GOC:bm]
is_a: GO:0001899 ! negative regulation of cytolysis by symbiont of host cells
is_a: GO:0032410 ! negative regulation of transporter activity
is_a: GO:0034763 ! negative regulation of transmembrane transport
is_a: GO:1901217 ! regulation of holin activity
is_a: GO:1902187 ! negative regulation of viral release from host cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034290 ! holin activity
relationship: negatively_regulates GO:0034290 ! holin activity
created_by: bf
creation_date: 2012-08-06T10:48:00Z

[Term]
id: GO:1901219
name: regulation of cardiac chamber morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac chamber morphogenesis." [GOC:BHF, GOC:TermGenie]
synonym: "regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:2000826 ! regulation of heart morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003206 ! cardiac chamber morphogenesis
relationship: regulates GO:0003206 ! cardiac chamber morphogenesis
created_by: rl
creation_date: 2012-08-06T17:59:11Z

[Term]
id: GO:1901220
name: negative regulation of cardiac chamber morphogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac chamber morphogenesis." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of heart chamber morphogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of cardiac chamber morphogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of heart chamber morphogenesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1901219 ! regulation of cardiac chamber morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003206 ! cardiac chamber morphogenesis
relationship: negatively_regulates GO:0003206 ! cardiac chamber morphogenesis
created_by: rl
creation_date: 2012-08-06T17:59:34Z

[Term]
id: GO:1901221
name: positive regulation of cardiac chamber morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiac chamber morphogenesis." [GOC:BHF, GOC:TermGenie]
synonym: "activation of cardiac chamber morphogenesis" NARROW [GOC:TermGenie]
synonym: "activation of heart chamber morphogenesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of heart chamber morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1901219 ! regulation of cardiac chamber morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003206 ! cardiac chamber morphogenesis
relationship: positively_regulates GO:0003206 ! cardiac chamber morphogenesis
created_by: rl
creation_date: 2012-08-06T17:59:42Z

[Term]
id: GO:1901222
name: regulation of NIK/NF-kappaB signaling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of NIK/NF-kappaB signaling." [GOC:TermGenie]
synonym: "regulation of NIK/NF-kappaB cascade" RELATED [GOC:signaling]
synonym: "regulation of non-canonical NF-KB signaling" BROAD [GOC:TermGenie]
synonym: "regulation of noncanonical NF-kappaB signaling" BROAD [GOC:TermGenie]
synonym: "regulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway" BROAD [GOC:TermGenie]
synonym: "regulation of p52-dependent NF-kappaB signaling" NARROW [GOC:TermGenie]
is_a: GO:1902531 ! regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0038061 ! NIK/NF-kappaB signaling
relationship: regulates GO:0038061 ! NIK/NF-kappaB signaling
created_by: hjd
creation_date: 2012-08-06T20:27:17Z

[Term]
id: GO:1901223
name: negative regulation of NIK/NF-kappaB signaling
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of NIK/NF-kappaB signaling." [GOC:TermGenie]
synonym: "down regulation of NIK/NF-kappaB cascade" RELATED [GOC:TermGenie]
synonym: "down regulation of non-canonical NF-KB signaling" BROAD [GOC:TermGenie]
synonym: "down regulation of noncanonical NF-kappaB signaling" BROAD [GOC:TermGenie]
synonym: "down regulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway" BROAD [GOC:TermGenie]
synonym: "down regulation of p52-dependent NF-kappaB signaling" NARROW [GOC:TermGenie]
synonym: "down-regulation of NIK/NF-kappaB cascade" RELATED [GOC:TermGenie]
synonym: "down-regulation of non-canonical NF-KB signaling" BROAD [GOC:TermGenie]
synonym: "down-regulation of noncanonical NF-kappaB signaling" BROAD [GOC:TermGenie]
synonym: "down-regulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway" BROAD [GOC:TermGenie]
synonym: "down-regulation of p52-dependent NF-kappaB signaling" NARROW [GOC:TermGenie]
synonym: "downregulation of NIK/NF-kappaB cascade" RELATED [GOC:TermGenie]
synonym: "downregulation of non-canonical NF-KB signaling" BROAD [GOC:TermGenie]
synonym: "downregulation of noncanonical NF-kappaB signaling" BROAD [GOC:TermGenie]
synonym: "downregulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway" BROAD [GOC:TermGenie]
synonym: "downregulation of p52-dependent NF-kappaB signaling" NARROW [GOC:TermGenie]
synonym: "inhibition of NIK/NF-kappaB cascade" NARROW [GOC:TermGenie]
synonym: "inhibition of non-canonical NF-KB signaling" BROAD [GOC:TermGenie]
synonym: "inhibition of noncanonical NF-kappaB signaling" BROAD [GOC:TermGenie]
synonym: "inhibition of noncanonical nuclear factor kappaB (NF-kappaB) pathway" BROAD [GOC:TermGenie]
synonym: "inhibition of p52-dependent NF-kappaB signaling" NARROW [GOC:TermGenie]
synonym: "negative regulation of NIK/NF-kappaB cascade" RELATED [GOC:signaling]
synonym: "negative regulation of non-canonical NF-KB signaling" BROAD [GOC:TermGenie]
synonym: "negative regulation of noncanonical NF-kappaB signaling" BROAD [GOC:TermGenie]
synonym: "negative regulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway" BROAD [GOC:TermGenie]
synonym: "negative regulation of p52-dependent NF-kappaB signaling" NARROW [GOC:TermGenie]
is_a: GO:1901222 ! regulation of NIK/NF-kappaB signaling
is_a: GO:1902532 ! negative regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0038061 ! NIK/NF-kappaB signaling
relationship: negatively_regulates GO:0038061 ! NIK/NF-kappaB signaling
created_by: hjd
creation_date: 2012-08-06T20:27:39Z

[Term]
id: GO:1901224
name: positive regulation of NIK/NF-kappaB signaling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of NIK/NF-kappaB signaling." [GOC:TermGenie]
synonym: "activation of NIK/NF-kappaB cascade" NARROW [GOC:TermGenie]
synonym: "activation of non-canonical NF-KB signaling" BROAD [GOC:TermGenie]
synonym: "activation of noncanonical NF-kappaB signaling" BROAD [GOC:TermGenie]
synonym: "activation of noncanonical nuclear factor kappaB (NF-kappaB) pathway" BROAD [GOC:TermGenie]
synonym: "activation of p52-dependent NF-kappaB signaling" NARROW [GOC:TermGenie]
synonym: "positive regulation of NIK/NF-kappaB cascade" RELATED [GOC:signaling]
synonym: "positive regulation of non-canonical NF-KB signaling" BROAD [GOC:TermGenie]
synonym: "positive regulation of noncanonical NF-kappaB signaling" BROAD [GOC:TermGenie]
synonym: "positive regulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway" BROAD [GOC:TermGenie]
synonym: "positive regulation of p52-dependent NF-kappaB signaling" NARROW [GOC:TermGenie]
synonym: "up regulation of NIK/NF-kappaB cascade" RELATED [GOC:TermGenie]
synonym: "up regulation of non-canonical NF-KB signaling" BROAD [GOC:TermGenie]
synonym: "up regulation of noncanonical NF-kappaB signaling" BROAD [GOC:TermGenie]
synonym: "up regulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway" BROAD [GOC:TermGenie]
synonym: "up regulation of p52-dependent NF-kappaB signaling" NARROW [GOC:TermGenie]
synonym: "up-regulation of NIK/NF-kappaB cascade" RELATED [GOC:TermGenie]
synonym: "up-regulation of non-canonical NF-KB signaling" BROAD [GOC:TermGenie]
synonym: "up-regulation of noncanonical NF-kappaB signaling" BROAD [GOC:TermGenie]
synonym: "up-regulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway" BROAD [GOC:TermGenie]
synonym: "up-regulation of p52-dependent NF-kappaB signaling" NARROW [GOC:TermGenie]
synonym: "upregulation of NIK/NF-kappaB cascade" RELATED [GOC:TermGenie]
synonym: "upregulation of non-canonical NF-KB signaling" BROAD [GOC:TermGenie]
synonym: "upregulation of noncanonical NF-kappaB signaling" BROAD [GOC:TermGenie]
synonym: "upregulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway" BROAD [GOC:TermGenie]
synonym: "upregulation of p52-dependent NF-kappaB signaling" NARROW [GOC:TermGenie]
is_a: GO:1901222 ! regulation of NIK/NF-kappaB signaling
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0038061 ! NIK/NF-kappaB signaling
relationship: positively_regulates GO:0038061 ! NIK/NF-kappaB signaling
created_by: hjd
creation_date: 2012-08-06T20:27:47Z

[Term]
id: GO:1901225
name: obsolete negative regulation of transcription from RNA polymerase II promoter involved in heart development
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of regulation of transcription from RNA polymerase II promoter involved in heart development." [GOC:BHF, GOC:TermGenie]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "down regulation of global transcription regulation from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "down regulation of global transcription regulation from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "down regulation of global transcription regulation from Pol II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "down regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "down regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "down regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "down regulation of regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "down regulation of regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "down regulation of regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "down regulation of regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "down regulation of regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "down regulation of regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie]
synonym: "down regulation of regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "down regulation of regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "down regulation of regulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie]
synonym: "down regulation of regulation of transcription from RNA polymerase II promoter, global involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "down regulation of regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "down regulation of regulation of transcription from RNA polymerase II promoter, global involved in heart development" RELATED [GOC:TermGenie]
synonym: "down-regulation of global transcription regulation from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "down-regulation of global transcription regulation from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "down-regulation of global transcription regulation from Pol II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "down-regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "down-regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "down-regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "down-regulation of regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "down-regulation of regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "down-regulation of regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "down-regulation of regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "down-regulation of regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "down-regulation of regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie]
synonym: "down-regulation of regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "down-regulation of regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "down-regulation of regulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie]
synonym: "down-regulation of regulation of transcription from RNA polymerase II promoter, global involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "down-regulation of regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "down-regulation of regulation of transcription from RNA polymerase II promoter, global involved in heart development" RELATED [GOC:TermGenie]
synonym: "downregulation of global transcription regulation from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "downregulation of global transcription regulation from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "downregulation of global transcription regulation from Pol II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "downregulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "downregulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "downregulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "downregulation of regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "downregulation of regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "downregulation of regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "downregulation of regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "downregulation of regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "downregulation of regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie]
synonym: "downregulation of regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "downregulation of regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "downregulation of regulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie]
synonym: "downregulation of regulation of transcription from RNA polymerase II promoter, global involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "downregulation of regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "downregulation of regulation of transcription from RNA polymerase II promoter, global involved in heart development" RELATED [GOC:TermGenie]
synonym: "inhibition of global transcription regulation from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "inhibition of global transcription regulation from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "inhibition of global transcription regulation from Pol II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "inhibition of regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "inhibition of regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "inhibition of regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "inhibition of regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "inhibition of regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "inhibition of regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "inhibition of regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "inhibition of regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "inhibition of regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie]
synonym: "inhibition of regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "inhibition of regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "inhibition of regulation of transcription from RNA polymerase II promoter involved in heart development" NARROW [GOC:TermGenie]
synonym: "inhibition of regulation of transcription from RNA polymerase II promoter, global involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "inhibition of regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "inhibition of regulation of transcription from RNA polymerase II promoter, global involved in heart development" RELATED [GOC:TermGenie]
synonym: "negative regulation of global transcription regulation from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "negative regulation of global transcription regulation from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "negative regulation of global transcription regulation from Pol II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "negative regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "negative regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "negative regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "negative regulation of regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "negative regulation of regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "negative regulation of regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "negative regulation of regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "negative regulation of regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "negative regulation of regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie]
synonym: "negative regulation of regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "negative regulation of regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "negative regulation of regulation of transcription from RNA polymerase II promoter, global involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "negative regulation of regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "negative regulation of regulation of transcription from RNA polymerase II promoter, global involved in heart development" RELATED [GOC:TermGenie]
synonym: "negative regulation of transcription from RNA polymerase II promoter involved in heart development" EXACT []
is_obsolete: true
created_by: rl
creation_date: 2012-08-07T07:04:07Z

[Term]
id: GO:1901226
name: obsolete positive regulation of transcription from RNA polymerase II promoter involved in heart development
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of regulation of transcription from RNA polymerase II promoter involved in heart development." [GOC:BHF, GOC:TermGenie]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "activation of global transcription regulation from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "activation of global transcription regulation from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "activation of global transcription regulation from Pol II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "activation of regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "activation of regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "activation of regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "activation of regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "activation of regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "activation of regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "activation of regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "activation of regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "activation of regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie]
synonym: "activation of regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "activation of regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "activation of regulation of transcription from RNA polymerase II promoter involved in heart development" NARROW [GOC:TermGenie]
synonym: "activation of regulation of transcription from RNA polymerase II promoter, global involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "activation of regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "activation of regulation of transcription from RNA polymerase II promoter, global involved in heart development" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription regulation from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription regulation from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription regulation from Pol II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "positive regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "positive regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "positive regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "positive regulation of regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "positive regulation of regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "positive regulation of regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "positive regulation of regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "positive regulation of regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "positive regulation of regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie]
synonym: "positive regulation of regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "positive regulation of regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "positive regulation of regulation of transcription from RNA polymerase II promoter, global involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "positive regulation of regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "positive regulation of regulation of transcription from RNA polymerase II promoter, global involved in heart development" RELATED [GOC:TermGenie]
synonym: "positive regulation of transcription from RNA polymerase II promoter involved in heart development" EXACT []
synonym: "up regulation of global transcription regulation from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "up regulation of global transcription regulation from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "up regulation of global transcription regulation from Pol II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "up regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "up regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "up regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "up regulation of regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "up regulation of regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "up regulation of regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "up regulation of regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "up regulation of regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "up regulation of regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie]
synonym: "up regulation of regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "up regulation of regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "up regulation of regulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie]
synonym: "up regulation of regulation of transcription from RNA polymerase II promoter, global involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "up regulation of regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "up regulation of regulation of transcription from RNA polymerase II promoter, global involved in heart development" RELATED [GOC:TermGenie]
synonym: "up-regulation of global transcription regulation from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "up-regulation of global transcription regulation from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "up-regulation of global transcription regulation from Pol II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "up-regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "up-regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "up-regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "up-regulation of regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "up-regulation of regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "up-regulation of regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "up-regulation of regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "up-regulation of regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "up-regulation of regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie]
synonym: "up-regulation of regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "up-regulation of regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "up-regulation of regulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie]
synonym: "up-regulation of regulation of transcription from RNA polymerase II promoter, global involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "up-regulation of regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "up-regulation of regulation of transcription from RNA polymerase II promoter, global involved in heart development" RELATED [GOC:TermGenie]
synonym: "upregulation of global transcription regulation from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "upregulation of global transcription regulation from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "upregulation of global transcription regulation from Pol II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "upregulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "upregulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "upregulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "upregulation of regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "upregulation of regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "upregulation of regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "upregulation of regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "upregulation of regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "upregulation of regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie]
synonym: "upregulation of regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "upregulation of regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "upregulation of regulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie]
synonym: "upregulation of regulation of transcription from RNA polymerase II promoter, global involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "upregulation of regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "upregulation of regulation of transcription from RNA polymerase II promoter, global involved in heart development" RELATED [GOC:TermGenie]
is_obsolete: true
created_by: rl
creation_date: 2012-08-07T07:04:32Z

[Term]
id: GO:1901227
name: negative regulation of transcription from RNA polymerase II promoter involved in heart development
namespace: biological_process
def: "Any negative regulation of transcription from RNA polymerase II promoter that is involved in heart development." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of global transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "down regulation of global transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "down regulation of global transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "down regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "down regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "down regulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie]
synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "down-regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "down-regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "down-regulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie]
synonym: "downregulation of global transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "downregulation of global transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "downregulation of global transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "downregulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "downregulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "downregulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie]
synonym: "inhibition of global transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "inhibition of global transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "inhibition of global transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "inhibition of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "inhibition of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "inhibition of transcription from RNA polymerase II promoter involved in heart development" NARROW [GOC:TermGenie]
synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "negative regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "negative regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "negative regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "negative regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "negative regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "negative regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie]
synonym: "negative regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "negative regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
is_a: GO:1901213 ! regulation of transcription from RNA polymerase II promoter involved in heart development
intersection_of: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
intersection_of: part_of GO:0007507 ! heart development
relationship: part_of GO:0007507 ! heart development
created_by: pr
creation_date: 2012-08-07T12:50:30Z

[Term]
id: GO:1901228
name: positive regulation of transcription from RNA polymerase II promoter involved in heart development
namespace: biological_process
def: "Any positive regulation of transcription from RNA polymerase II promoter that is involved in heart development." [GOC:BHF, GOC:TermGenie]
synonym: "activation of global transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "activation of global transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "activation of global transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase II promoter involved in heart development" NARROW [GOC:TermGenie]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "positive regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "positive regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "positive regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "positive regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "stimulation of global transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "stimulation of global transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "stimulation of global transcription from RNA polymerase II promoter involved in heart development" NARROW [GOC:TermGenie]
synonym: "stimulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "stimulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "stimulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie]
synonym: "up regulation of global transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "up regulation of global transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "up regulation of global transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie]
synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie]
synonym: "upregulation of global transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "upregulation of global transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie]
synonym: "upregulation of global transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie]
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
is_a: GO:1901213 ! regulation of transcription from RNA polymerase II promoter involved in heart development
intersection_of: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
intersection_of: part_of GO:0007507 ! heart development
relationship: part_of GO:0007507 ! heart development
created_by: pr
creation_date: 2012-08-07T12:53:01Z

[Term]
id: GO:1901229
name: regulation of non-canonical Wnt signaling pathway via JNK cascade
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of non-canonical Wnt signaling pathway via JNK cascade." [GOC:BHF, GOC:TermGenie]
synonym: "regulation of non-canonical Wnt receptor signaling pathway via JNK cascade" EXACT []
synonym: "regulation of non-canonical Wnt receptor signalling pathway via JNK cascade" EXACT [GOC:TermGenie]
synonym: "regulation of non-canonical Wnt-activated signaling pathway via JNK cascade" EXACT [GOC:signaling]
is_a: GO:2000050 ! regulation of non-canonical Wnt signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0038031 ! non-canonical Wnt signaling pathway via JNK cascade
relationship: regulates GO:0038031 ! non-canonical Wnt signaling pathway via JNK cascade
created_by: vk
creation_date: 2012-08-07T14:14:16Z

[Term]
id: GO:1901230
name: negative regulation of non-canonical Wnt signaling pathway via JNK cascade
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of non-canonical Wnt signaling pathway via JNK cascade." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of non-canonical Wnt receptor signaling pathway via JNK cascade" EXACT [GOC:TermGenie]
synonym: "down regulation of non-canonical Wnt receptor signalling pathway via JNK cascade" EXACT [GOC:TermGenie]
synonym: "down-regulation of non-canonical Wnt receptor signaling pathway via JNK cascade" EXACT [GOC:TermGenie]
synonym: "down-regulation of non-canonical Wnt receptor signalling pathway via JNK cascade" EXACT [GOC:TermGenie]
synonym: "downregulation of non-canonical Wnt receptor signaling pathway via JNK cascade" EXACT [GOC:TermGenie]
synonym: "downregulation of non-canonical Wnt receptor signalling pathway via JNK cascade" EXACT [GOC:TermGenie]
synonym: "inhibition of non-canonical Wnt receptor signaling pathway via JNK cascade" NARROW [GOC:TermGenie]
synonym: "inhibition of non-canonical Wnt receptor signalling pathway via JNK cascade" NARROW [GOC:TermGenie]
synonym: "negative regulation of non-canonical Wnt receptor signaling pathway via JNK cascade" EXACT []
synonym: "negative regulation of non-canonical Wnt receptor signalling pathway via JNK cascade" EXACT [GOC:TermGenie]
synonym: "negative regulation of non-canonical Wnt-activated signaling pathway via JNK cascade" RELATED [GOC:signaling]
is_a: GO:1901229 ! regulation of non-canonical Wnt signaling pathway via JNK cascade
is_a: GO:2000051 ! negative regulation of non-canonical Wnt signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0038031 ! non-canonical Wnt signaling pathway via JNK cascade
relationship: negatively_regulates GO:0038031 ! non-canonical Wnt signaling pathway via JNK cascade
created_by: vk
creation_date: 2012-08-07T14:14:39Z

[Term]
id: GO:1901231
name: positive regulation of non-canonical Wnt signaling pathway via JNK cascade
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of non-canonical Wnt signaling pathway via JNK cascade." [GOC:BHF, GOC:TermGenie]
synonym: "activation of non-canonical Wnt receptor signaling pathway via JNK cascade" NARROW [GOC:TermGenie]
synonym: "activation of non-canonical Wnt receptor signalling pathway via JNK cascade" NARROW [GOC:TermGenie]
synonym: "positive regulation of non-canonical Wnt receptor signaling pathway via JNK cascade" EXACT []
synonym: "positive regulation of non-canonical Wnt receptor signalling pathway via JNK cascade" EXACT [GOC:TermGenie]
synonym: "positive regulation of non-canonical Wnt-activated signaling pathway via JNK cascade" EXACT [GOC:signaling]
synonym: "up regulation of non-canonical Wnt receptor signaling pathway via JNK cascade" EXACT [GOC:TermGenie]
synonym: "up regulation of non-canonical Wnt receptor signalling pathway via JNK cascade" EXACT [GOC:TermGenie]
synonym: "up-regulation of non-canonical Wnt receptor signaling pathway via JNK cascade" EXACT [GOC:TermGenie]
synonym: "up-regulation of non-canonical Wnt receptor signalling pathway via JNK cascade" EXACT [GOC:TermGenie]
synonym: "upregulation of non-canonical Wnt receptor signaling pathway via JNK cascade" EXACT [GOC:TermGenie]
synonym: "upregulation of non-canonical Wnt receptor signalling pathway via JNK cascade" EXACT [GOC:TermGenie]
is_a: GO:1901229 ! regulation of non-canonical Wnt signaling pathway via JNK cascade
is_a: GO:2000052 ! positive regulation of non-canonical Wnt signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0038031 ! non-canonical Wnt signaling pathway via JNK cascade
relationship: positively_regulates GO:0038031 ! non-canonical Wnt signaling pathway via JNK cascade
created_by: vk
creation_date: 2012-08-07T14:14:48Z

[Term]
id: GO:1901232
name: regulation of convergent extension involved in axis elongation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of convergent extension involved in axis elongation." [GOC:BHF, GOC:TermGenie]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0048638 ! regulation of developmental growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060028 ! convergent extension involved in axis elongation
relationship: regulates GO:0060028 ! convergent extension involved in axis elongation
created_by: vk
creation_date: 2012-08-07T14:21:46Z

[Term]
id: GO:1901233
name: negative regulation of convergent extension involved in axis elongation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of convergent extension involved in axis elongation." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of convergent extension involved in axis elongation" EXACT [GOC:TermGenie]
synonym: "down-regulation of convergent extension involved in axis elongation" EXACT [GOC:TermGenie]
synonym: "downregulation of convergent extension involved in axis elongation" EXACT [GOC:TermGenie]
synonym: "inhibition of convergent extension involved in axis elongation" NARROW [GOC:TermGenie]
is_a: GO:0048640 ! negative regulation of developmental growth
is_a: GO:1901232 ! regulation of convergent extension involved in axis elongation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060028 ! convergent extension involved in axis elongation
relationship: negatively_regulates GO:0060028 ! convergent extension involved in axis elongation
created_by: vk
creation_date: 2012-08-07T14:22:11Z

[Term]
id: GO:1901234
name: positive regulation of convergent extension involved in axis elongation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of convergent extension involved in axis elongation." [GOC:BHF, GOC:TermGenie]
synonym: "activation of convergent extension involved in axis elongation" NARROW [GOC:TermGenie]
synonym: "up regulation of convergent extension involved in axis elongation" EXACT [GOC:TermGenie]
synonym: "up-regulation of convergent extension involved in axis elongation" EXACT [GOC:TermGenie]
synonym: "upregulation of convergent extension involved in axis elongation" EXACT [GOC:TermGenie]
is_a: GO:0048639 ! positive regulation of developmental growth
is_a: GO:1901232 ! regulation of convergent extension involved in axis elongation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060028 ! convergent extension involved in axis elongation
relationship: positively_regulates GO:0060028 ! convergent extension involved in axis elongation
created_by: vk
creation_date: 2012-08-07T14:22:19Z

[Term]
id: GO:1901235
name: (R)-carnitine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of (R)-carnitine from one side of the membrane to the other." [GOC:TermGenie, PMID:16365042, PMID:20357772, PMID:20829798]
xref: RHEA:34962
is_a: GO:0015226 ! carnitine transmembrane transporter activity
relationship: part_of GO:1902270 ! (R)-carnitine transmembrane transport
created_by: jl
creation_date: 2012-08-07T14:46:17Z

[Term]
id: GO:1901236
name: 4-(trimethylammonio)butanoate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of 4-(trimethylammonio)butanoate from one side of the membrane to the other." [GOC:TermGenie, PMID:16952940, PMID:21784948]
xref: RHEA:32838
is_a: GO:0008519 ! ammonium transmembrane transporter activity
is_a: GO:0015651 ! quaternary ammonium group transmembrane transporter activity
created_by: jl
creation_date: 2012-08-07T14:46:52Z

[Term]
id: GO:1901237
name: tungstate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of tungstate from one side of the membrane to the other." [GOC:TermGenie, PMID:16952940, PMID:21784948]
xref: RHEA:32842
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity
created_by: jl
creation_date: 2012-08-07T14:47:15Z

[Term]
id: GO:1901238
name: tungstate transmembrane-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + tungstate(in) = ADP + phosphate + tungstate(out)." [GOC:TermGenie, PMID:16952940, PMID:21784948]
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances
is_a: GO:1901237 ! tungstate transmembrane transporter activity
created_by: jl
creation_date: 2012-08-07T14:47:36Z

[Term]
id: GO:1901239
name: malonate(1-) transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of malonate(1-) from one side of the membrane to the other." [GOC:TermGenie, PMID:9128730, PMID:9573154]
xref: RHEA:33118
is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity
created_by: jl
creation_date: 2012-08-07T15:09:02Z

[Term]
id: GO:1901241
name: 4-hydroxyphenylacetate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of 4-hydroxyphenylacetate from one side of the membrane to the other." [GOC:TermGenie, PMID:9315705]
xref: RHEA:33178
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity
created_by: jl
creation_date: 2012-08-07T15:09:49Z

[Term]
id: GO:1901242
name: doxorubicin transmembrane-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + doxorubicin(in) = ADP + phosphate + doxorubicin(out)." [GOC:TermGenie, PMID:12057006]
is_a: GO:0008519 ! ammonium transmembrane transporter activity
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:0019829 ! cation-transporting ATPase activity
is_a: GO:1901505 ! carbohydrate derivative transporter activity
created_by: jl
creation_date: 2012-08-07T15:10:13Z

[Term]
id: GO:1901243
name: methionine transmembrane-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + methionine(in) = ADP + phosphate + methionine(out)." [GOC:TermGenie, PMID:12169620, PMID:12819857]
xref: RHEA:32830
is_a: GO:0019829 ! cation-transporting ATPase activity
is_a: GO:0043865 ! methionine transmembrane transporter activity
created_by: jl
creation_date: 2012-08-07T15:59:50Z

[Term]
id: GO:1901244
name: positive regulation of transcription from RNA polymerase II promoter involved in defense response to fungus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter to protect the cell or organism in response to the presence of a fungus." [GOC:kmv, GOC:TermGenie]
synonym: "activation of global transcription from RNA polymerase II promoter involved in defence response to fungi" RELATED [GOC:TermGenie]
synonym: "activation of global transcription from RNA polymerase II promoter involved in defence response to fungus" RELATED [GOC:TermGenie]
synonym: "activation of global transcription from RNA polymerase II promoter involved in defense response to fungi" RELATED [GOC:TermGenie]
synonym: "activation of global transcription from RNA polymerase II promoter involved in defense response to fungus" RELATED [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase II promoter involved in defence response to fungi" NARROW [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase II promoter involved in defence response to fungus" NARROW [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase II promoter involved in defense response to fungi" NARROW [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase II promoter involved in defense response to fungus" NARROW [GOC:TermGenie]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in defence response to fungi" RELATED [GOC:TermGenie]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in defence response to fungus" RELATED [GOC:TermGenie]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in defense response to fungi" RELATED [GOC:TermGenie]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in defense response to fungus" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription from Pol II promoter involved in defence response to fungi" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription from Pol II promoter involved in defence response to fungus" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription from Pol II promoter involved in defense response to fungi" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription from Pol II promoter involved in defense response to fungus" RELATED [GOC:TermGenie]
synonym: "positive regulation of transcription from Pol II promoter involved in defence response to fungi" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription from Pol II promoter involved in defence response to fungus" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription from Pol II promoter involved in defense response to fungi" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription from Pol II promoter involved in defense response to fungus" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription from RNA polymerase II promoter involved in defence response to fungi" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription from RNA polymerase II promoter involved in defence response to fungus" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription from RNA polymerase II promoter involved in defense response to fungi" EXACT [GOC:TermGenie]
synonym: "stimulation of global transcription from RNA polymerase II promoter involved in defence response to fungi" NARROW [GOC:TermGenie]
synonym: "stimulation of global transcription from RNA polymerase II promoter involved in defence response to fungus" NARROW [GOC:TermGenie]
synonym: "stimulation of global transcription from RNA polymerase II promoter involved in defense response to fungi" NARROW [GOC:TermGenie]
synonym: "stimulation of global transcription from RNA polymerase II promoter involved in defense response to fungus" NARROW [GOC:TermGenie]
synonym: "stimulation of transcription from RNA polymerase II promoter involved in defence response to fungi" EXACT [GOC:TermGenie]
synonym: "stimulation of transcription from RNA polymerase II promoter involved in defence response to fungus" EXACT [GOC:TermGenie]
synonym: "stimulation of transcription from RNA polymerase II promoter involved in defense response to fungi" EXACT [GOC:TermGenie]
synonym: "stimulation of transcription from RNA polymerase II promoter involved in defense response to fungus" EXACT [GOC:TermGenie]
synonym: "up regulation of global transcription from RNA polymerase II promoter involved in defence response to fungi" RELATED [GOC:TermGenie]
synonym: "up regulation of global transcription from RNA polymerase II promoter involved in defence response to fungus" RELATED [GOC:TermGenie]
synonym: "up regulation of global transcription from RNA polymerase II promoter involved in defense response to fungi" RELATED [GOC:TermGenie]
synonym: "up regulation of global transcription from RNA polymerase II promoter involved in defense response to fungus" RELATED [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase II promoter involved in defence response to fungi" EXACT [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase II promoter involved in defence response to fungus" EXACT [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase II promoter involved in defense response to fungi" EXACT [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase II promoter involved in defense response to fungus" EXACT [GOC:TermGenie]
synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in defence response to fungi" RELATED [GOC:TermGenie]
synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in defence response to fungus" RELATED [GOC:TermGenie]
synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in defense response to fungi" RELATED [GOC:TermGenie]
synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in defense response to fungus" RELATED [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase II promoter involved in defence response to fungi" EXACT [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase II promoter involved in defence response to fungus" EXACT [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase II promoter involved in defense response to fungi" EXACT [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase II promoter involved in defense response to fungus" EXACT [GOC:TermGenie]
synonym: "upregulation of global transcription from RNA polymerase II promoter involved in defence response to fungi" RELATED [GOC:TermGenie]
synonym: "upregulation of global transcription from RNA polymerase II promoter involved in defence response to fungus" RELATED [GOC:TermGenie]
synonym: "upregulation of global transcription from RNA polymerase II promoter involved in defense response to fungi" RELATED [GOC:TermGenie]
synonym: "upregulation of global transcription from RNA polymerase II promoter involved in defense response to fungus" RELATED [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase II promoter involved in defence response to fungi" EXACT [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase II promoter involved in defence response to fungus" EXACT [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase II promoter involved in defense response to fungi" EXACT [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase II promoter involved in defense response to fungus" EXACT [GOC:TermGenie]
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
intersection_of: part_of GO:0050832 ! defense response to fungus
relationship: part_of GO:0050832 ! defense response to fungus
created_by: kmv
creation_date: 2012-08-07T18:40:02Z

[Term]
id: GO:1901245
name: positive regulation of toll-like receptor 9 signaling pathway by B cell receptor internalization
namespace: biological_process
def: "The movement of a B cell receptor (BCR) from the plasma membrane to the inside of the cell, which results in positive regulation of toll-like receptor 9 (TLR9) signaling. For example, internalized BCR signals to recruit TLR9 from multiple small endosomes to large autophagosome-like compartments to enhance TLR9 signaling." [GOC:amm, GOC:bf, GOC:TermGenie, PMID:18513998]
synonym: "BCR-induced TLR9 recruitment" NARROW [PMID:18513998]
synonym: "positive regulation of TLR9 signaling pathway by B cell receptor internalization" EXACT [GOC:TermGenie]
synonym: "positive regulation of TLR9 signaling pathway by BCR endocytosis" EXACT [GOC:TermGenie]
synonym: "positive regulation of TLR9 signaling pathway by BCR receptor internalization" EXACT [GOC:TermGenie]
synonym: "positive regulation of toll-like receptor 9 signaling pathway by BCR endocytosis" EXACT [GOC:TermGenie]
synonym: "positive regulation of toll-like receptor 9 signaling pathway by BCR receptor internalization" EXACT [GOC:TermGenie]
synonym: "positive regulation of toll-like receptor 9 signalling pathway by B cell receptor internalization" EXACT [GOC:TermGenie]
synonym: "positive regulation of toll-like receptor 9 signalling pathway by BCR endocytosis" EXACT [GOC:TermGenie]
synonym: "positive regulation of toll-like receptor 9 signalling pathway by BCR receptor internalization" EXACT [GOC:TermGenie]
is_a: GO:0034165 ! positive regulation of toll-like receptor 9 signaling pathway
is_a: GO:0036300 ! B cell receptor internalization
is_a: GO:0038010 ! positive regulation of signal transduction by receptor internalization
intersection_of: GO:0036300 ! B cell receptor internalization
intersection_of: positively_regulates GO:0034162 ! toll-like receptor 9 signaling pathway
relationship: positively_regulates GO:0034162 ! toll-like receptor 9 signaling pathway
created_by: bf
creation_date: 2012-08-08T08:12:44Z

[Term]
id: GO:1901246
name: regulation of lung ciliated cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lung ciliated cell differentiation." [GOC:BHF, GOC:TermGenie]
is_a: GO:0030856 ! regulation of epithelial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061141 ! lung ciliated cell differentiation
relationship: regulates GO:0061141 ! lung ciliated cell differentiation
created_by: vk
creation_date: 2012-08-08T08:58:34Z

[Term]
id: GO:1901247
name: negative regulation of lung ciliated cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lung ciliated cell differentiation." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of lung ciliated cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of lung ciliated cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of lung ciliated cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of lung ciliated cell differentiation" NARROW [GOC:TermGenie]
is_a: GO:0030857 ! negative regulation of epithelial cell differentiation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1901246 ! regulation of lung ciliated cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061141 ! lung ciliated cell differentiation
relationship: negatively_regulates GO:0061141 ! lung ciliated cell differentiation
created_by: vk
creation_date: 2012-08-08T08:58:58Z

[Term]
id: GO:1901248
name: positive regulation of lung ciliated cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lung ciliated cell differentiation." [GOC:BHF, GOC:TermGenie]
synonym: "activation of lung ciliated cell differentiation" NARROW [GOC:TermGenie]
synonym: "up regulation of lung ciliated cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of lung ciliated cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of lung ciliated cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0030858 ! positive regulation of epithelial cell differentiation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1901246 ! regulation of lung ciliated cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061141 ! lung ciliated cell differentiation
relationship: positively_regulates GO:0061141 ! lung ciliated cell differentiation
created_by: vk
creation_date: 2012-08-08T08:59:05Z

[Term]
id: GO:1901249
name: regulation of lung goblet cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lung goblet cell differentiation." [GOC:BHF, GOC:TermGenie]
synonym: "regulation of pulmonary goblet cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0030856 ! regulation of epithelial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060480 ! lung goblet cell differentiation
relationship: regulates GO:0060480 ! lung goblet cell differentiation
created_by: vk
creation_date: 2012-08-08T08:59:12Z

[Term]
id: GO:1901250
name: negative regulation of lung goblet cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lung goblet cell differentiation." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of lung goblet cell differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of pulmonary goblet cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of lung goblet cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of pulmonary goblet cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of lung goblet cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of pulmonary goblet cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of lung goblet cell differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of pulmonary goblet cell differentiation" NARROW [GOC:TermGenie]
synonym: "negative regulation of pulmonary goblet cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0030857 ! negative regulation of epithelial cell differentiation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1901249 ! regulation of lung goblet cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060480 ! lung goblet cell differentiation
relationship: negatively_regulates GO:0060480 ! lung goblet cell differentiation
created_by: vk
creation_date: 2012-08-08T08:59:36Z

[Term]
id: GO:1901251
name: positive regulation of lung goblet cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lung goblet cell differentiation." [GOC:BHF, GOC:TermGenie]
synonym: "activation of lung goblet cell differentiation" NARROW [GOC:TermGenie]
synonym: "activation of pulmonary goblet cell differentiation" NARROW [GOC:TermGenie]
synonym: "positive regulation of pulmonary goblet cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of lung goblet cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of pulmonary goblet cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of lung goblet cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of pulmonary goblet cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of lung goblet cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of pulmonary goblet cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0030858 ! positive regulation of epithelial cell differentiation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1901249 ! regulation of lung goblet cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060480 ! lung goblet cell differentiation
relationship: positively_regulates GO:0060480 ! lung goblet cell differentiation
created_by: vk
creation_date: 2012-08-08T08:59:44Z

[Term]
id: GO:1901252
name: regulation of intracellular transport of viral material
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of egress of virus within host cell." [GOC:bf, GOC:jl, GOC:TermGenie]
synonym: "regulation of egress of virus within host cell" RELATED []
synonym: "regulation of movement of virus within host cell" EXACT [GOC:TermGenie]
synonym: "regulation of viral egress" EXACT [GOC:TermGenie]
is_a: GO:0032386 ! regulation of intracellular transport
is_a: GO:1903900 ! regulation of viral life cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0075733 ! intracellular transport of virus
relationship: regulates GO:0075733 ! intracellular transport of virus
created_by: ss
creation_date: 2012-08-09T05:45:25Z

[Term]
id: GO:1901253
name: negative regulation of intracellular transport of viral material
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of intracellular transport of viral material." [GOC:bf, GOC:jl, GOC:TermGenie]
synonym: "down regulation of egress of virus within host cell" EXACT [GOC:TermGenie]
synonym: "down regulation of movement of virus within host cell" EXACT [GOC:TermGenie]
synonym: "down regulation of viral egress" EXACT [GOC:TermGenie]
synonym: "down-regulation of egress of virus within host cell" EXACT [GOC:TermGenie]
synonym: "down-regulation of movement of virus within host cell" EXACT [GOC:TermGenie]
synonym: "down-regulation of viral egress" EXACT [GOC:TermGenie]
synonym: "downregulation of egress of virus within host cell" EXACT [GOC:TermGenie]
synonym: "downregulation of movement of virus within host cell" EXACT [GOC:TermGenie]
synonym: "downregulation of viral egress" EXACT [GOC:TermGenie]
synonym: "inhibition of egress of virus within host cell" NARROW [GOC:TermGenie]
synonym: "inhibition of movement of virus within host cell" EXACT [GOC:TermGenie]
synonym: "inhibition of viral egress" EXACT [GOC:TermGenie]
synonym: "negative regulation of egress of virus within host cell" RELATED []
synonym: "negative regulation of movement of virus within host cell" EXACT [GOC:TermGenie]
synonym: "negative regulation of viral egress" EXACT [GOC:TermGenie]
is_a: GO:0032387 ! negative regulation of intracellular transport
is_a: GO:1901252 ! regulation of intracellular transport of viral material
is_a: GO:1903901 ! negative regulation of viral life cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0075733 ! intracellular transport of virus
relationship: negatively_regulates GO:0075733 ! intracellular transport of virus
created_by: ss
creation_date: 2012-08-09T05:45:47Z

[Term]
id: GO:1901254
name: positive regulation of intracellular transport of viral material
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of intracellular transport of viral material." [GOC:bf, GOC:jl, GOC:TermGenie]
synonym: "activation of egress of virus within host cell" NARROW [GOC:TermGenie]
synonym: "activation of movement of virus within host cell" EXACT [GOC:TermGenie]
synonym: "activation of viral egress" EXACT [GOC:TermGenie]
synonym: "positive regulation of egress of virus within host cell" RELATED []
synonym: "positive regulation of movement of virus within host cell" EXACT [GOC:TermGenie]
synonym: "positive regulation of viral egress" EXACT [GOC:TermGenie]
synonym: "up regulation of egress of virus within host cell" EXACT [GOC:TermGenie]
synonym: "up regulation of movement of virus within host cell" EXACT [GOC:TermGenie]
synonym: "up regulation of viral egress" EXACT [GOC:TermGenie]
synonym: "up-regulation of egress of virus within host cell" EXACT [GOC:TermGenie]
synonym: "up-regulation of movement of virus within host cell" EXACT [GOC:TermGenie]
synonym: "up-regulation of viral egress" EXACT [GOC:TermGenie]
synonym: "upregulation of egress of virus within host cell" EXACT [GOC:TermGenie]
synonym: "upregulation of movement of virus within host cell" EXACT [GOC:TermGenie]
synonym: "upregulation of viral egress" EXACT [GOC:TermGenie]
is_a: GO:0032388 ! positive regulation of intracellular transport
is_a: GO:1901252 ! regulation of intracellular transport of viral material
is_a: GO:1903902 ! positive regulation of viral life cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0075733 ! intracellular transport of virus
relationship: positively_regulates GO:0075733 ! intracellular transport of virus
created_by: ss
creation_date: 2012-08-09T05:45:54Z

[Term]
id: GO:1901255
name: nucleotide-excision repair involved in interstrand cross-link repair
namespace: biological_process
def: "Any nucleotide-excision repair that is involved in interstrand cross-link repair." [GOC:TermGenie, PMID:22064477]
synonym: "NER involved in ICL repair" EXACT [GOC:TermGenie]
synonym: "NER involved in interstrand cross-link repair" EXACT [GOC:TermGenie]
synonym: "nucleotide-excision repair involved in ICL repair" EXACT [GOC:TermGenie]
is_a: GO:0006289 ! nucleotide-excision repair
intersection_of: GO:0006289 ! nucleotide-excision repair
intersection_of: part_of GO:0036297 ! interstrand cross-link repair
relationship: part_of GO:0036297 ! interstrand cross-link repair
created_by: vw
creation_date: 2012-08-09T06:09:50Z

[Term]
id: GO:1901256
name: regulation of macrophage colony-stimulating factor production
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of macrophage colony-stimulating factor production." [GOC:BHF, GOC:TermGenie]
synonym: "regulation of M-CSF production" EXACT [GOC:TermGenie]
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0036301 ! macrophage colony-stimulating factor production
relationship: regulates GO:0036301 ! macrophage colony-stimulating factor production
created_by: vk
creation_date: 2012-08-10T08:28:08Z

[Term]
id: GO:1901257
name: negative regulation of macrophage colony-stimulating factor production
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of macrophage colony-stimulating factor production." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of M-CSF production" EXACT [GOC:TermGenie]
synonym: "down regulation of macrophage colony-stimulating factor production" EXACT [GOC:TermGenie]
synonym: "down-regulation of M-CSF production" EXACT [GOC:TermGenie]
synonym: "down-regulation of macrophage colony-stimulating factor production" EXACT [GOC:TermGenie]
synonym: "downregulation of M-CSF production" EXACT [GOC:TermGenie]
synonym: "downregulation of macrophage colony-stimulating factor production" EXACT [GOC:TermGenie]
synonym: "inhibition of M-CSF production" EXACT [GOC:TermGenie]
synonym: "inhibition of macrophage colony-stimulating factor production" NARROW [GOC:TermGenie]
synonym: "negative regulation of M-CSF production" EXACT [GOC:TermGenie]
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:1901256 ! regulation of macrophage colony-stimulating factor production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0036301 ! macrophage colony-stimulating factor production
relationship: negatively_regulates GO:0036301 ! macrophage colony-stimulating factor production
created_by: vk
creation_date: 2012-08-10T08:28:28Z

[Term]
id: GO:1901258
name: positive regulation of macrophage colony-stimulating factor production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of macrophage colony-stimulating factor production." [GOC:BHF, GOC:TermGenie]
synonym: "activation of M-CSF production" EXACT [GOC:TermGenie]
synonym: "activation of macrophage colony-stimulating factor production" NARROW [GOC:TermGenie]
synonym: "positive regulation of M-CSF production" EXACT [GOC:TermGenie]
synonym: "up regulation of M-CSF production" EXACT [GOC:TermGenie]
synonym: "up regulation of macrophage colony-stimulating factor production" EXACT [GOC:TermGenie]
synonym: "up-regulation of M-CSF production" EXACT [GOC:TermGenie]
synonym: "up-regulation of macrophage colony-stimulating factor production" EXACT [GOC:TermGenie]
synonym: "upregulation of M-CSF production" EXACT [GOC:TermGenie]
synonym: "upregulation of macrophage colony-stimulating factor production" EXACT [GOC:TermGenie]
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:1901256 ! regulation of macrophage colony-stimulating factor production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0036301 ! macrophage colony-stimulating factor production
relationship: positively_regulates GO:0036301 ! macrophage colony-stimulating factor production
created_by: vk
creation_date: 2012-08-10T08:28:36Z

[Term]
id: GO:1901259
name: chloroplast rRNA processing
namespace: biological_process
def: "Any rRNA processing that takes place in chloroplast." [GOC:TermGenie]
is_a: GO:0006364 ! rRNA processing
intersection_of: GO:0006364 ! rRNA processing
intersection_of: occurs_in GO:0009507 ! chloroplast
relationship: occurs_in GO:0009507 ! chloroplast
created_by: tb
creation_date: 2012-08-10T17:43:19Z

[Term]
id: GO:1901260
name: peptidyl-lysine hydroxylation involved in bacterial-type EF-P lysine modification
namespace: biological_process
def: "Any peptidyl-lysine hydroxylation that is involved in bacterial-type EF-P lysine modification." [GOC:imk, GOC:TermGenie, PMID:22706199]
synonym: "EF-P lysine hydroxylation" RELATED [PMID:3555234]
is_a: GO:0017185 ! peptidyl-lysine hydroxylation
intersection_of: GO:0017185 ! peptidyl-lysine hydroxylation
intersection_of: part_of GO:0072580 ! bacterial-type EF-P lysine modification
relationship: part_of GO:0072580 ! bacterial-type EF-P lysine modification
created_by: bf
creation_date: 2012-08-14T13:20:12Z

[Term]
id: GO:1901261
name: regulation of sorocarp spore cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sorocarp spore cell differentiation." [GOC:rjd, GOC:TermGenie]
is_a: GO:0031156 ! regulation of sorocarp development
is_a: GO:0045595 ! regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044671 ! sorocarp spore cell differentiation
relationship: regulates GO:0044671 ! sorocarp spore cell differentiation
created_by: jl
creation_date: 2012-08-15T09:44:30Z

[Term]
id: GO:1901262
name: negative regulation of sorocarp spore cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sorocarp spore cell differentiation." [GOC:rjd, GOC:TermGenie]
synonym: "down regulation of sorocarp spore cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of sorocarp spore cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of sorocarp spore cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of sorocarp spore cell differentiation" NARROW [GOC:TermGenie]
is_a: GO:0010648 ! negative regulation of cell communication
is_a: GO:0032108 ! negative regulation of response to nutrient levels
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0075262 ! negative regulation of spore-bearing organ development
is_a: GO:1901261 ! regulation of sorocarp spore cell differentiation
is_a: GO:1903665 ! negative regulation of asexual reproduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044671 ! sorocarp spore cell differentiation
relationship: negatively_regulates GO:0044671 ! sorocarp spore cell differentiation
created_by: jl
creation_date: 2012-08-15T09:44:50Z

[Term]
id: GO:1901263
name: positive regulation of sorocarp spore cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sorocarp spore cell differentiation." [GOC:rjd, GOC:TermGenie]
synonym: "activation of sorocarp spore cell differentiation" NARROW [GOC:TermGenie]
synonym: "up regulation of sorocarp spore cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of sorocarp spore cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of sorocarp spore cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0010647 ! positive regulation of cell communication
is_a: GO:0032109 ! positive regulation of response to nutrient levels
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0075261 ! positive regulation of spore-bearing organ development
is_a: GO:1901261 ! regulation of sorocarp spore cell differentiation
is_a: GO:1903666 ! positive regulation of asexual reproduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044671 ! sorocarp spore cell differentiation
relationship: positively_regulates GO:0044671 ! sorocarp spore cell differentiation
created_by: jl
creation_date: 2012-08-15T09:44:58Z

[Term]
id: GO:1901264
name: carbohydrate derivative transport
namespace: biological_process
def: "The directed movement of a carbohydrate derivative into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf, GOC:jl, GOC:TermGenie]
is_a: GO:0044765 ! single-organism transport
is_a: GO:0071702 ! organic substance transport
created_by: bf
creation_date: 2012-08-16T14:51:22Z

[Term]
id: GO:1901265
name: nucleoside phosphate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with nucleoside phosphate." [GOC:TermGenie]
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding
created_by: bf
creation_date: 2012-08-17T12:59:58Z

[Term]
id: GO:1901266
name: cephalosporin C metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cephalosporin C." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00172]
synonym: "cephalosporin C metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019752 ! carboxylic acid metabolic process
is_a: GO:0043645 ! cephalosporin metabolic process
created_by: yaf
creation_date: 2012-08-17T14:25:59Z

[Term]
id: GO:1901267
name: cephalosporin C catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cephalosporin C." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00172]
synonym: "cephalosporin C breakdown" EXACT [GOC:TermGenie]
synonym: "cephalosporin C catabolism" EXACT [GOC:TermGenie]
synonym: "cephalosporin C degradation" EXACT [GOC:TermGenie]
is_a: GO:0030655 ! beta-lactam antibiotic catabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process
is_a: GO:1901266 ! cephalosporin C metabolic process
created_by: yaf
creation_date: 2012-08-17T14:26:19Z

[Term]
id: GO:1901268
name: cephalosporin C biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cephalosporin C." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00172]
synonym: "cephalosporin C anabolism" EXACT [GOC:TermGenie]
synonym: "cephalosporin C biosynthesis" EXACT [GOC:TermGenie]
synonym: "cephalosporin C formation" EXACT [GOC:TermGenie]
synonym: "cephalosporin C synthesis" EXACT [GOC:TermGenie]
is_a: GO:0043646 ! cephalosporin biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
is_a: GO:1901266 ! cephalosporin C metabolic process
created_by: yaf
creation_date: 2012-08-17T14:26:31Z

[Term]
id: GO:1901269
name: lipooligosaccharide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lipooligosaccharide." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00501]
synonym: "lipooligosaccharide metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009311 ! oligosaccharide metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process
created_by: yaf
creation_date: 2012-08-17T14:31:26Z

[Term]
id: GO:1901270
name: lipooligosaccharide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lipooligosaccharide." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00501]
synonym: "lipooligosaccharide breakdown" EXACT [GOC:TermGenie]
synonym: "lipooligosaccharide catabolism" EXACT [GOC:TermGenie]
synonym: "lipooligosaccharide degradation" EXACT [GOC:TermGenie]
is_a: GO:0009313 ! oligosaccharide catabolic process
is_a: GO:1901136 ! carbohydrate derivative catabolic process
is_a: GO:1901269 ! lipooligosaccharide metabolic process
created_by: yaf
creation_date: 2012-08-17T14:31:48Z

[Term]
id: GO:1901271
name: lipooligosaccharide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lipooligosaccharide." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00501]
synonym: "lipooligosaccharide anabolism" EXACT [GOC:TermGenie]
synonym: "lipooligosaccharide biosynthesis" EXACT [GOC:TermGenie]
synonym: "lipooligosaccharide formation" EXACT [GOC:TermGenie]
synonym: "lipooligosaccharide synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009312 ! oligosaccharide biosynthetic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process
is_a: GO:1901269 ! lipooligosaccharide metabolic process
created_by: yaf
creation_date: 2012-08-17T14:31:55Z

[Term]
id: GO:1901272
name: 2-dehydro-3-deoxy-D-gluconic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 2-dehydro-3-deoxy-D-gluconic acid." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00856]
synonym: "2-dehydro-3-deoxy-D-gluconic acid metabolism" EXACT [GOC:TermGenie]
is_a: GO:0005996 ! monosaccharide metabolic process
is_a: GO:0019520 ! aldonic acid metabolic process
created_by: yaf
creation_date: 2012-08-17T14:46:15Z

[Term]
id: GO:1901273
name: 2-dehydro-3-deoxy-D-gluconic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 2-dehydro-3-deoxy-D-gluconic acid." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00856]
synonym: "2-dehydro-3-deoxy-D-gluconic acid breakdown" EXACT [GOC:TermGenie]
synonym: "2-dehydro-3-deoxy-D-gluconic acid catabolism" EXACT [GOC:TermGenie]
synonym: "2-dehydro-3-deoxy-D-gluconic acid degradation" EXACT [GOC:TermGenie]
is_a: GO:0046176 ! aldonic acid catabolic process
is_a: GO:0046365 ! monosaccharide catabolic process
is_a: GO:1901272 ! 2-dehydro-3-deoxy-D-gluconic acid metabolic process
created_by: yaf
creation_date: 2012-08-17T14:46:37Z

[Term]
id: GO:1901274
name: 2-dehydro-3-deoxy-D-gluconic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 2-dehydro-3-deoxy-D-gluconic acid." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00856]
synonym: "2-dehydro-3-deoxy-D-gluconic acid anabolism" EXACT [GOC:TermGenie]
synonym: "2-dehydro-3-deoxy-D-gluconic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "2-dehydro-3-deoxy-D-gluconic acid formation" EXACT [GOC:TermGenie]
synonym: "2-dehydro-3-deoxy-D-gluconic acid synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046175 ! aldonic acid biosynthetic process
is_a: GO:0046364 ! monosaccharide biosynthetic process
is_a: GO:1901272 ! 2-dehydro-3-deoxy-D-gluconic acid metabolic process
created_by: yaf
creation_date: 2012-08-17T14:46:44Z

[Term]
id: GO:1901275
name: tartrate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tartrate." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00839]
synonym: "tartrate metabolism" EXACT [GOC:TermGenie]
is_a: GO:0044710 ! single-organism metabolic process
created_by: yaf
creation_date: 2012-08-17T14:52:19Z

[Term]
id: GO:1901276
name: tartrate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tartrate." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00839]
synonym: "tartrate breakdown" EXACT [GOC:TermGenie]
synonym: "tartrate catabolism" EXACT [GOC:TermGenie]
synonym: "tartrate degradation" EXACT [GOC:TermGenie]
is_a: GO:0044712 ! single-organism catabolic process
is_a: GO:1901275 ! tartrate metabolic process
created_by: yaf
creation_date: 2012-08-17T14:52:40Z

[Term]
id: GO:1901277
name: tartrate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tartrate." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00839]
synonym: "tartrate anabolism" EXACT [GOC:TermGenie]
synonym: "tartrate biosynthesis" EXACT [GOC:TermGenie]
synonym: "tartrate formation" EXACT [GOC:TermGenie]
synonym: "tartrate synthesis" EXACT [GOC:TermGenie]
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:1901275 ! tartrate metabolic process
created_by: yaf
creation_date: 2012-08-17T14:52:48Z

[Term]
id: GO:1901278
name: D-ribose 5-phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-ribose 5-phosphate." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00293]
synonym: "D-ribose 5-phosphate metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019693 ! ribose phosphate metabolic process
created_by: yaf
creation_date: 2012-08-17T14:59:58Z

[Term]
id: GO:1901279
name: D-ribose 5-phosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-ribose 5-phosphate." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00293]
synonym: "D-ribose 5-phosphate breakdown" EXACT [GOC:TermGenie]
synonym: "D-ribose 5-phosphate catabolism" EXACT [GOC:TermGenie]
synonym: "D-ribose 5-phosphate degradation" EXACT [GOC:TermGenie]
is_a: GO:0046434 ! organophosphate catabolic process
is_a: GO:1901136 ! carbohydrate derivative catabolic process
is_a: GO:1901278 ! D-ribose 5-phosphate metabolic process
created_by: yaf
creation_date: 2012-08-17T15:00:19Z

[Term]
id: GO:1901280
name: D-ribose 5-phosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of D-ribose 5-phosphate." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00293]
synonym: "D-ribose 5-phosphate anabolism" EXACT [GOC:TermGenie]
synonym: "D-ribose 5-phosphate biosynthesis" EXACT [GOC:TermGenie]
synonym: "D-ribose 5-phosphate formation" EXACT [GOC:TermGenie]
synonym: "D-ribose 5-phosphate synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046390 ! ribose phosphate biosynthetic process
is_a: GO:1901278 ! D-ribose 5-phosphate metabolic process
created_by: yaf
creation_date: 2012-08-17T15:00:27Z

[Term]
id: GO:1901281
name: fructoselysine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of fructoselysine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00784]
synonym: "fructosyllysine breakdown" EXACT [GOC:TermGenie]
synonym: "fructosyllysine catabolic process" EXACT []
synonym: "fructosyllysine catabolism" EXACT [GOC:TermGenie]
synonym: "fructosyllysine degradation" EXACT [GOC:TermGenie]
is_a: GO:0009063 ! cellular amino acid catabolic process
is_a: GO:0030392 ! fructosamine catabolic process
is_a: GO:0030393 ! fructoselysine metabolic process
created_by: yaf
creation_date: 2012-08-17T15:04:43Z

[Term]
id: GO:1901282
name: fructoselysine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of fructoselysine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00784]
synonym: "fructosyllysine anabolism" EXACT [GOC:TermGenie]
synonym: "fructosyllysine biosynthesis" EXACT [GOC:TermGenie]
synonym: "fructosyllysine biosynthetic process" EXACT []
synonym: "fructosyllysine formation" EXACT [GOC:TermGenie]
synonym: "fructosyllysine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0008652 ! cellular amino acid biosynthetic process
is_a: GO:0030391 ! fructosamine biosynthetic process
is_a: GO:0030393 ! fructoselysine metabolic process
created_by: yaf
creation_date: 2012-08-17T15:05:05Z

[Term]
id: GO:1901283
name: 5,6,7,8-tetrahydromethanopterin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 5,6,7,8-tetrahydromethanopterin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00065]
synonym: "5,6,7,8-tetrahydromethanopterin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0043648 ! dicarboxylic acid metabolic process
is_a: GO:2001117 ! tetrahydromethanopterin metabolic process
created_by: yaf
creation_date: 2012-08-17T15:32:33Z

[Term]
id: GO:1901284
name: 5,6,7,8-tetrahydromethanopterin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 5,6,7,8-tetrahydromethanopterin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00065]
synonym: "5,6,7,8-tetrahydromethanopterin breakdown" EXACT [GOC:TermGenie]
synonym: "5,6,7,8-tetrahydromethanopterin catabolism" EXACT [GOC:TermGenie]
synonym: "5,6,7,8-tetrahydromethanopterin degradation" EXACT [GOC:TermGenie]
is_a: GO:0042560 ! pteridine-containing compound catabolic process
is_a: GO:0043649 ! dicarboxylic acid catabolic process
is_a: GO:0046434 ! organophosphate catabolic process
is_a: GO:1901283 ! 5,6,7,8-tetrahydromethanopterin metabolic process
created_by: yaf
creation_date: 2012-08-17T15:32:54Z

[Term]
id: GO:1901285
name: 5,6,7,8-tetrahydromethanopterin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 5,6,7,8-tetrahydromethanopterin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00065]
synonym: "5,6,7,8-tetrahydromethanopterin anabolism" EXACT [GOC:TermGenie]
synonym: "5,6,7,8-tetrahydromethanopterin biosynthesis" EXACT [GOC:TermGenie]
synonym: "5,6,7,8-tetrahydromethanopterin formation" EXACT [GOC:TermGenie]
synonym: "5,6,7,8-tetrahydromethanopterin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0043650 ! dicarboxylic acid biosynthetic process
is_a: GO:1901283 ! 5,6,7,8-tetrahydromethanopterin metabolic process
is_a: GO:2001118 ! tetrahydromethanopterin biosynthetic process
created_by: yaf
creation_date: 2012-08-17T15:33:02Z

[Term]
id: GO:1901286
name: iron-sulfur-molybdenum cofactor metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving iron-sulfur-molybdenum cofactor." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00782]
synonym: "FeMo-co metabolic process" EXACT [GOC:yaf]
synonym: "FeMo-co metabolism" EXACT [GOC:yaf]
synonym: "iron-molybdenum cofactor metabolic process" EXACT [GOC:yaf]
synonym: "iron-molybdenum cofactor metabolism" EXACT [GOC:yaf]
synonym: "iron-sulfur-molybdenum cofactor metabolism" EXACT [GOC:TermGenie]
is_a: GO:0051186 ! cofactor metabolic process
created_by: yaf
creation_date: 2012-08-17T15:39:14Z

[Term]
id: GO:1901287
name: iron-sulfur-molybdenum cofactor catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of iron-sulfur-molybdenum cofactor." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00782]
synonym: "FeMo-co breakdown" EXACT [GOC:yaf]
synonym: "FeMo-co catabolic process" EXACT [GOC:yaf]
synonym: "FeMo-co catabolism" EXACT [GOC:yaf]
synonym: "FeMo-co degradation" EXACT [GOC:yaf]
synonym: "iron-molybdenum breakdown" EXACT [GOC:yaf]
synonym: "iron-molybdenum catabolic process" EXACT [GOC:yaf]
synonym: "iron-molybdenum catabolism" EXACT [GOC:yaf]
synonym: "iron-molybdenum degradation" EXACT [GOC:yaf]
synonym: "iron-sulfur-molybdenum cofactor breakdown" EXACT [GOC:TermGenie]
synonym: "iron-sulfur-molybdenum cofactor catabolism" EXACT [GOC:TermGenie]
synonym: "iron-sulfur-molybdenum cofactor degradation" EXACT [GOC:TermGenie]
is_a: GO:0051187 ! cofactor catabolic process
is_a: GO:1901286 ! iron-sulfur-molybdenum cofactor metabolic process
created_by: yaf
creation_date: 2012-08-17T15:39:36Z

[Term]
id: GO:1901288
name: iron-sulfur-molybdenum cofactor biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of iron-sulfur-molybdenum cofactor." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00782]
synonym: "FeMo-co anabolism" EXACT [GOC:yaf]
synonym: "FeMo-co biosynthesis" EXACT [GOC:yaf]
synonym: "FeMo-co biosynthetic process" EXACT [GOC:yaf]
synonym: "FeMo-co formation" EXACT [GOC:yaf]
synonym: "FeMo-co synthesis" EXACT [GOC:yaf]
synonym: "iron-molybdenum cofactor anabolism" EXACT [GOC:yaf]
synonym: "iron-molybdenum cofactor biosynthesis" EXACT [GOC:yaf]
synonym: "iron-molybdenum cofactor biosynthetic process" EXACT [GOC:yaf]
synonym: "iron-molybdenum cofactor formation" EXACT [GOC:yaf]
synonym: "iron-molybdenum cofactor synthesis" EXACT [GOC:yaf]
synonym: "iron-sulfur-molybdenum cofactor anabolism" EXACT [GOC:TermGenie]
synonym: "iron-sulfur-molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie]
synonym: "iron-sulfur-molybdenum cofactor formation" EXACT [GOC:TermGenie]
synonym: "iron-sulfur-molybdenum cofactor synthesis" EXACT [GOC:TermGenie]
is_a: GO:0051188 ! cofactor biosynthetic process
is_a: GO:1901286 ! iron-sulfur-molybdenum cofactor metabolic process
created_by: yaf
creation_date: 2012-08-17T15:39:48Z

[Term]
id: GO:1901289
name: succinyl-CoA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of succinyl-CoA." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00929]
synonym: "succinyl-CoA breakdown" EXACT [GOC:TermGenie]
synonym: "succinyl-CoA catabolism" EXACT [GOC:TermGenie]
synonym: "succinyl-CoA degradation" EXACT [GOC:TermGenie]
is_a: GO:0006104 ! succinyl-CoA metabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:1901575 ! organic substance catabolic process
created_by: yaf
creation_date: 2012-08-17T16:13:37Z

[Term]
id: GO:1901290
name: succinyl-CoA biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of succinyl-CoA." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00929]
synonym: "succinyl-CoA anabolism" EXACT [GOC:TermGenie]
synonym: "succinyl-CoA biosynthesis" EXACT [GOC:TermGenie]
synonym: "succinyl-CoA formation" EXACT [GOC:TermGenie]
synonym: "succinyl-CoA synthesis" EXACT [GOC:TermGenie]
is_a: GO:0006104 ! succinyl-CoA metabolic process
is_a: GO:0071616 ! acyl-CoA biosynthetic process
created_by: yaf
creation_date: 2012-08-17T16:13:57Z

[Term]
id: GO:1901291
name: negative regulation of double-strand break repair via single-strand annealing
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of double-strand break repair via single-strand annealing." [GOC:sart, GOC:TermGenie]
synonym: "down regulation of double-strand break repair via single-strand annealing" EXACT [GOC:TermGenie]
synonym: "down-regulation of double-strand break repair via single-strand annealing" EXACT [GOC:TermGenie]
synonym: "downregulation of double-strand break repair via single-strand annealing" EXACT [GOC:TermGenie]
synonym: "inhibition of double-strand break repair via single-strand annealing" NARROW [GOC:TermGenie]
is_a: GO:2000780 ! negative regulation of double-strand break repair
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045002 ! double-strand break repair via single-strand annealing
relationship: negatively_regulates GO:0045002 ! double-strand break repair via single-strand annealing
created_by: sart
creation_date: 2012-08-20T09:03:03Z

[Term]
id: GO:1901292
name: nucleoside phosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a nucleoside phosphate." [GOC:TermGenie]
synonym: "nucleoside phosphate breakdown" EXACT [GOC:TermGenie]
synonym: "nucleoside phosphate catabolism" EXACT [GOC:TermGenie]
synonym: "nucleoside phosphate degradation" EXACT [GOC:TermGenie]
is_a: GO:0006753 ! nucleoside phosphate metabolic process
is_a: GO:0034655 ! nucleobase-containing compound catabolic process
is_a: GO:0044712 ! single-organism catabolic process
is_a: GO:0046434 ! organophosphate catabolic process
created_by: bf
creation_date: 2012-08-20T12:33:25Z

[Term]
id: GO:1901293
name: nucleoside phosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a nucleoside phosphate." [GOC:TermGenie]
synonym: "nucleoside phosphate anabolism" EXACT [GOC:TermGenie]
synonym: "nucleoside phosphate biosynthesis" EXACT [GOC:TermGenie]
synonym: "nucleoside phosphate formation" EXACT [GOC:TermGenie]
synonym: "nucleoside phosphate synthesis" EXACT [GOC:TermGenie]
is_a: GO:0006753 ! nucleoside phosphate metabolic process
is_a: GO:0034654 ! nucleobase-containing compound biosynthetic process
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:0090407 ! organophosphate biosynthetic process
created_by: bf
creation_date: 2012-08-20T12:33:45Z

[Term]
id: GO:1901294
name: negative regulation of SREBP signaling pathway by negative regulation of DNA binding
namespace: biological_process
def: "Negative regulation of DNA binding that results in negative regulation of a SREBP signaling pathway." [GOC:TermGenie, PMID:22017871]
synonym: "inhibition of SREBP-dependent transcription by blocking DNA binding" EXACT [PMID:22017871]
synonym: "negative regulation of SREBP signaling pathway by down regulation of DNA binding" EXACT [GOC:TermGenie]
synonym: "negative regulation of SREBP signaling pathway by down-regulation of DNA binding" EXACT [GOC:TermGenie]
synonym: "negative regulation of SREBP signaling pathway by downregulation of DNA binding" EXACT [GOC:TermGenie]
synonym: "negative regulation of SREBP signaling pathway by inhibition of DNA binding" NARROW [GOC:TermGenie]
synonym: "negative regulation of SREBP-mediated signaling pathway by down regulation of DNA binding" EXACT [GOC:TermGenie]
synonym: "negative regulation of SREBP-mediated signaling pathway by down-regulation of DNA binding" EXACT [GOC:TermGenie]
synonym: "negative regulation of SREBP-mediated signaling pathway by downregulation of DNA binding" EXACT [GOC:TermGenie]
synonym: "negative regulation of SREBP-mediated signaling pathway by inhibition of DNA binding" NARROW [GOC:TermGenie]
synonym: "negative regulation of SREBP-mediated signaling pathway by negative regulation of DNA binding" EXACT [GOC:TermGenie]
synonym: "negative regulation of SREBP-mediated signalling pathway by down regulation of DNA binding" EXACT [GOC:TermGenie]
synonym: "negative regulation of SREBP-mediated signalling pathway by down-regulation of DNA binding" EXACT [GOC:TermGenie]
synonym: "negative regulation of SREBP-mediated signalling pathway by downregulation of DNA binding" EXACT [GOC:TermGenie]
synonym: "negative regulation of SREBP-mediated signalling pathway by inhibition of DNA binding" NARROW [GOC:TermGenie]
synonym: "negative regulation of SREBP-mediated signalling pathway by negative regulation of DNA binding" EXACT [GOC:TermGenie]
is_a: GO:0043392 ! negative regulation of DNA binding
is_a: GO:2000639 ! negative regulation of SREBP signaling pathway
intersection_of: GO:0043392 ! negative regulation of DNA binding
intersection_of: negatively_regulates GO:0032933 ! SREBP signaling pathway
relationship: negatively_regulates GO:0032933 ! SREBP signaling pathway
created_by: bf
creation_date: 2012-08-20T14:11:03Z

[Term]
id: GO:1901295
name: regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment." [GOC:BHF, GOC:TermGenie]
synonym: "regulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment" EXACT []
synonym: "regulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie]
synonym: "regulation of canonical Wnt-activated signaling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:signaling]
is_a: GO:0010453 ! regulation of cell fate commitment
is_a: GO:1905066 ! regulation of canonical Wnt signaling pathway involved in heart development
is_a: GO:2000725 ! regulation of cardiac muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061317 ! canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment
relationship: regulates GO:0061317 ! canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment
created_by: vk
creation_date: 2012-08-21T09:06:32Z

[Term]
id: GO:1901296
name: negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie]
synonym: "down regulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie]
synonym: "down-regulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie]
synonym: "down-regulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie]
synonym: "downregulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie]
synonym: "downregulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie]
synonym: "inhibition of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment" NARROW [GOC:TermGenie]
synonym: "inhibition of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie]
synonym: "negative regulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment" EXACT []
synonym: "negative regulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie]
synonym: "negative regulation of canonical Wnt-activated signaling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:signaling]
is_a: GO:0010454 ! negative regulation of cell fate commitment
is_a: GO:1901295 ! regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment
is_a: GO:1905067 ! negative regulation of canonical Wnt signaling pathway involved in heart development
is_a: GO:2000726 ! negative regulation of cardiac muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061317 ! canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment
relationship: negatively_regulates GO:0061317 ! canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment
created_by: vk
creation_date: 2012-08-21T09:06:52Z

[Term]
id: GO:1901297
name: positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment." [GOC:BHF, GOC:TermGenie]
synonym: "activation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment" NARROW [GOC:TermGenie]
synonym: "activation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie]
synonym: "positive regulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment" EXACT []
synonym: "positive regulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie]
synonym: "positive regulation of canonical Wnt-activated signaling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:signaling]
synonym: "up regulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie]
synonym: "up regulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie]
synonym: "up-regulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie]
synonym: "up-regulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie]
synonym: "upregulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie]
synonym: "upregulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie]
is_a: GO:0010455 ! positive regulation of cell fate commitment
is_a: GO:1901295 ! regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment
is_a: GO:1905068 ! positive regulation of canonical Wnt signaling pathway involved in heart development
is_a: GO:2000727 ! positive regulation of cardiac muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061317 ! canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment
relationship: positively_regulates GO:0061317 ! canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment
created_by: vk
creation_date: 2012-08-21T09:06:59Z

[Term]
id: GO:1901298
name: regulation of hydrogen peroxide-mediated programmed cell death
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hydrogen peroxide-mediated programmed cell death." [GOC:BHF, GOC:TermGenie]
is_a: GO:0043067 ! regulation of programmed cell death
is_a: GO:1903205 ! regulation of hydrogen peroxide-induced cell death
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010421 ! hydrogen peroxide-mediated programmed cell death
relationship: regulates GO:0010421 ! hydrogen peroxide-mediated programmed cell death
created_by: vk
creation_date: 2012-08-21T09:44:59Z

[Term]
id: GO:1901299
name: negative regulation of hydrogen peroxide-mediated programmed cell death
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide-mediated programmed cell death." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of hydrogen peroxide-mediated programmed cell death" EXACT [GOC:TermGenie]
synonym: "down-regulation of hydrogen peroxide-mediated programmed cell death" EXACT [GOC:TermGenie]
synonym: "downregulation of hydrogen peroxide-mediated programmed cell death" EXACT [GOC:TermGenie]
synonym: "inhibition of hydrogen peroxide-mediated programmed cell death" NARROW [GOC:TermGenie]
is_a: GO:0043069 ! negative regulation of programmed cell death
is_a: GO:1901298 ! regulation of hydrogen peroxide-mediated programmed cell death
is_a: GO:1903206 ! negative regulation of hydrogen peroxide-induced cell death
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010421 ! hydrogen peroxide-mediated programmed cell death
relationship: negatively_regulates GO:0010421 ! hydrogen peroxide-mediated programmed cell death
created_by: vk
creation_date: 2012-08-21T09:45:21Z

[Term]
id: GO:1901300
name: positive regulation of hydrogen peroxide-mediated programmed cell death
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hydrogen peroxide-mediated programmed cell death." [GOC:BHF, GOC:TermGenie]
synonym: "activation of hydrogen peroxide-mediated programmed cell death" NARROW [GOC:TermGenie]
synonym: "up regulation of hydrogen peroxide-mediated programmed cell death" EXACT [GOC:TermGenie]
synonym: "up-regulation of hydrogen peroxide-mediated programmed cell death" EXACT [GOC:TermGenie]
synonym: "upregulation of hydrogen peroxide-mediated programmed cell death" EXACT [GOC:TermGenie]
is_a: GO:0043068 ! positive regulation of programmed cell death
is_a: GO:1901033 ! positive regulation of response to reactive oxygen species
is_a: GO:1901298 ! regulation of hydrogen peroxide-mediated programmed cell death
is_a: GO:1903209 ! positive regulation of oxidative stress-induced cell death
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010421 ! hydrogen peroxide-mediated programmed cell death
relationship: positively_regulates GO:0010421 ! hydrogen peroxide-mediated programmed cell death
created_by: vk
creation_date: 2012-08-21T09:45:29Z

[Term]
id: GO:1901301
name: regulation of cargo loading into COPII-coated vesicle
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cargo loading into COPII-coated vesicle." [GOC:TermGenie, PMID:15899885]
synonym: "regulation of cargo loading into COPII vesicle" EXACT [GOC:TermGenie]
synonym: "regulation of cargo selection into COPII-coated vesicle" EXACT [GOC:TermGenie]
synonym: "regulation of COPII coat-cargo complex assembly" RELATED [GOC:TermGenie]
is_a: GO:0033043 ! regulation of organelle organization
is_a: GO:0043254 ! regulation of protein complex assembly
is_a: GO:0060628 ! regulation of ER to Golgi vesicle-mediated transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0090110 ! cargo loading into COPII-coated vesicle
relationship: regulates GO:0090110 ! cargo loading into COPII-coated vesicle
created_by: bf
creation_date: 2012-08-21T13:03:00Z

[Term]
id: GO:1901303
name: negative regulation of cargo loading into COPII-coated vesicle
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cargo loading into a COPII-coated vesicle." [GOC:TermGenie, PMID:15899885]
synonym: "down regulation of cargo loading into COPII vesicle" EXACT [GOC:TermGenie]
synonym: "down regulation of cargo loading into COPII-coated vesicle" EXACT [GOC:TermGenie]
synonym: "down regulation of cargo selection into COPII-coated vesicle" EXACT [GOC:TermGenie]
synonym: "down regulation of COPII coat-cargo complex assembly" RELATED [GOC:TermGenie]
synonym: "down-regulation of cargo loading into COPII vesicle" EXACT [GOC:TermGenie]
synonym: "down-regulation of cargo loading into COPII-coated vesicle" EXACT [GOC:TermGenie]
synonym: "down-regulation of cargo selection into COPII-coated vesicle" EXACT [GOC:TermGenie]
synonym: "down-regulation of COPII coat-cargo complex assembly" RELATED [GOC:TermGenie]
synonym: "downregulation of cargo loading into COPII vesicle" EXACT [GOC:TermGenie]
synonym: "downregulation of cargo loading into COPII-coated vesicle" EXACT [GOC:TermGenie]
synonym: "downregulation of cargo selection into COPII-coated vesicle" EXACT [GOC:TermGenie]
synonym: "downregulation of COPII coat-cargo complex assembly" RELATED [GOC:TermGenie]
synonym: "inhibition of cargo loading into COPII vesicle" EXACT [GOC:TermGenie]
synonym: "inhibition of cargo loading into COPII-coated vesicle" NARROW [GOC:TermGenie]
synonym: "inhibition of cargo selection into COPII-coated vesicle" EXACT [GOC:TermGenie]
synonym: "inhibition of COPII coat-cargo complex assembly" RELATED [GOC:TermGenie]
synonym: "inhibition of COPII vesicle protein binding" NARROW [PMID:15899885]
synonym: "inhibition of protein sorting into COPII-coated vesicles" EXACT [PMID:15899885]
synonym: "negative regulation of cargo loading into COPII vesicle" EXACT [GOC:TermGenie]
synonym: "negative regulation of cargo selection into COPII-coated vesicle" EXACT [GOC:TermGenie]
synonym: "negative regulation of COPII coat-cargo complex assembly" RELATED [GOC:TermGenie]
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:0031333 ! negative regulation of protein complex assembly
is_a: GO:1901301 ! regulation of cargo loading into COPII-coated vesicle
is_a: GO:1903650 ! negative regulation of cytoplasmic transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0090110 ! cargo loading into COPII-coated vesicle
relationship: negatively_regulates GO:0090110 ! cargo loading into COPII-coated vesicle
created_by: bf
creation_date: 2012-08-21T13:05:46Z

[Term]
id: GO:1901304
name: regulation of spermidine biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of spermidine biosynthetic process." [GOC:pm, GOC:TermGenie]
synonym: "regulation of spermidine anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of spermidine biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of spermidine formation" EXACT [GOC:TermGenie]
synonym: "regulation of spermidine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010967 ! regulation of polyamine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008295 ! spermidine biosynthetic process
relationship: regulates GO:0008295 ! spermidine biosynthetic process
created_by: pm
creation_date: 2012-08-21T13:58:23Z

[Term]
id: GO:1901305
name: negative regulation of spermidine biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of spermidine biosynthetic process." [GOC:pm, GOC:TermGenie]
synonym: "down regulation of spermidine anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of spermidine biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of spermidine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of spermidine formation" EXACT [GOC:TermGenie]
synonym: "down regulation of spermidine synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of spermidine anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of spermidine biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of spermidine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of spermidine formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of spermidine synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of spermidine anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of spermidine biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of spermidine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of spermidine formation" EXACT [GOC:TermGenie]
synonym: "downregulation of spermidine synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of spermidine anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of spermidine biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of spermidine biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of spermidine formation" EXACT [GOC:TermGenie]
synonym: "inhibition of spermidine synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of spermidine anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of spermidine biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of spermidine formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of spermidine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0033239 ! negative regulation of cellular amine metabolic process
is_a: GO:1901304 ! regulation of spermidine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008295 ! spermidine biosynthetic process
relationship: negatively_regulates GO:0008295 ! spermidine biosynthetic process
created_by: pm
creation_date: 2012-08-21T13:58:45Z

[Term]
id: GO:1901307
name: positive regulation of spermidine biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of spermidine biosynthetic process." [GOC:pm, GOC:TermGenie]
synonym: "activation of spermidine anabolism" EXACT [GOC:TermGenie]
synonym: "activation of spermidine biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of spermidine biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of spermidine formation" EXACT [GOC:TermGenie]
synonym: "activation of spermidine synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of spermidine anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of spermidine biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of spermidine formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of spermidine synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of spermidine anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of spermidine biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of spermidine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of spermidine formation" EXACT [GOC:TermGenie]
synonym: "up regulation of spermidine synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of spermidine anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of spermidine biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of spermidine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of spermidine formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of spermidine synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of spermidine anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of spermidine biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of spermidine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of spermidine formation" EXACT [GOC:TermGenie]
synonym: "upregulation of spermidine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0033240 ! positive regulation of cellular amine metabolic process
is_a: GO:1901304 ! regulation of spermidine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008295 ! spermidine biosynthetic process
relationship: positively_regulates GO:0008295 ! spermidine biosynthetic process
created_by: pm
creation_date: 2012-08-21T14:02:58Z

[Term]
id: GO:1901308
name: regulation of sterol regulatory element binding protein cleavage
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sterol regulatory element binding protein cleavage." [GOC:TermGenie]
synonym: "regulation of SREBP cleavage" EXACT [GOC:TermGenie]
is_a: GO:0032268 ! regulation of cellular protein metabolic process
is_a: GO:0070613 ! regulation of protein processing
is_a: GO:2000638 ! regulation of SREBP signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035103 ! sterol regulatory element binding protein cleavage
relationship: regulates GO:0035103 ! sterol regulatory element binding protein cleavage
created_by: bf
creation_date: 2012-08-21T16:43:12Z

[Term]
id: GO:1901309
name: negative regulation of sterol regulatory element binding protein cleavage
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sterol regulatory element binding protein cleavage." [GOC:TermGenie, PMID:15899885, PMID:16525117]
synonym: "down regulation of SREBP cleavage" EXACT [GOC:TermGenie]
synonym: "down regulation of sterol regulatory element binding protein cleavage" EXACT [GOC:TermGenie]
synonym: "down-regulation of SREBP cleavage" EXACT [GOC:TermGenie]
synonym: "down-regulation of sterol regulatory element binding protein cleavage" EXACT [GOC:TermGenie]
synonym: "downregulation of SREBP cleavage" EXACT [GOC:TermGenie]
synonym: "downregulation of sterol regulatory element binding protein cleavage" EXACT [GOC:TermGenie]
synonym: "inhibition of SREBP cleavage" EXACT [GOC:TermGenie]
synonym: "inhibition of SREBP processing" EXACT [GOC:bf]
synonym: "inhibition of sterol regulatory element binding protein cleavage" NARROW [GOC:TermGenie]
synonym: "negative regulation of SREBP cleavage" EXACT [GOC:TermGenie]
is_a: GO:0010955 ! negative regulation of protein processing
is_a: GO:1901308 ! regulation of sterol regulatory element binding protein cleavage
is_a: GO:2000639 ! negative regulation of SREBP signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035103 ! sterol regulatory element binding protein cleavage
relationship: negatively_regulates GO:0035103 ! sterol regulatory element binding protein cleavage
created_by: bf
creation_date: 2012-08-21T16:43:32Z

[Term]
id: GO:1901310
name: positive regulation of sterol regulatory element binding protein cleavage
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sterol regulatory element binding protein cleavage." [GOC:TermGenie, PMID:15899885, PMID:16525117]
synonym: "activation of SREBP cleavage" EXACT [GOC:TermGenie]
synonym: "activation of sterol regulatory element binding protein cleavage" NARROW [GOC:TermGenie]
synonym: "positive regulation of SREBP cleavage" EXACT [GOC:TermGenie]
synonym: "up regulation of SREBP cleavage" EXACT [GOC:TermGenie]
synonym: "up regulation of sterol regulatory element binding protein cleavage" EXACT [GOC:TermGenie]
synonym: "up-regulation of SREBP cleavage" EXACT [GOC:TermGenie]
synonym: "up-regulation of sterol regulatory element binding protein cleavage" EXACT [GOC:TermGenie]
synonym: "upregulation of SREBP cleavage" EXACT [GOC:TermGenie]
synonym: "upregulation of sterol regulatory element binding protein cleavage" EXACT [GOC:TermGenie]
is_a: GO:0010954 ! positive regulation of protein processing
is_a: GO:1901308 ! regulation of sterol regulatory element binding protein cleavage
is_a: GO:2000640 ! positive regulation of SREBP signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035103 ! sterol regulatory element binding protein cleavage
relationship: positively_regulates GO:0035103 ! sterol regulatory element binding protein cleavage
created_by: bf
creation_date: 2012-08-21T16:43:40Z

[Term]
id: GO:1901311
name: obsolete regulation of gene expression involved in extracellular matrix organization
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of gene expression involved in extracellular matrix organization." [GOC:BHF, GOC:TermGenie]
comment: This term was made obolete is that in these terms the 'involved in' process is not truly involved_in (i.e. part_of) the process but instead is causally upstream of it. We advise replacing annotations to these terms with annotations + extensions using the causally_upstream_of relation e.g. P1234 regulation of gene expression [causally_upstream_of] extracellular matrix organization.
synonym: "regulation of expression of extracellular matrix proteins" EXACT [GOC:TermGenie]
synonym: "regulation of extracellular matrix protein production" RELATED [GOC:TermGenie]
is_obsolete: true
consider: GO:0010468
created_by: vk
creation_date: 2012-08-22T09:18:13Z

[Term]
id: GO:1901312
name: obsolete negative regulation of gene expression involved in extracellular matrix organization
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of gene expression involved in extracellular matrix organization." [GOC:BHF, GOC:TermGenie]
comment: This term was made obolete is that in these terms the 'involved in' process is not truly involved_in (i.e. part_of) the process but instead is causally upstream of it. We advise replacing annotations to these terms with annotations + extensions using the causally_upstream_of relation e.g. P1234 regulation of gene expression [causally_upstream_of] extracellular matrix organization.
synonym: "down regulation of expression of extracellular matrix proteins" EXACT [GOC:TermGenie]
synonym: "down regulation of extracellular matrix protein production" RELATED [GOC:TermGenie]
synonym: "down regulation of gene expression involved in extracellular matrix organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of expression of extracellular matrix proteins" EXACT [GOC:TermGenie]
synonym: "down-regulation of extracellular matrix protein production" RELATED [GOC:TermGenie]
synonym: "down-regulation of gene expression involved in extracellular matrix organization" EXACT [GOC:TermGenie]
synonym: "downregulation of expression of extracellular matrix proteins" EXACT [GOC:TermGenie]
synonym: "downregulation of extracellular matrix protein production" RELATED [GOC:TermGenie]
synonym: "downregulation of gene expression involved in extracellular matrix organization" EXACT [GOC:TermGenie]
synonym: "inhibition of expression of extracellular matrix proteins" EXACT [GOC:TermGenie]
synonym: "inhibition of extracellular matrix protein production" RELATED [GOC:TermGenie]
synonym: "inhibition of gene expression involved in extracellular matrix organization" NARROW [GOC:TermGenie]
synonym: "negative regulation of expression of extracellular matrix proteins" EXACT [GOC:TermGenie]
synonym: "negative regulation of extracellular matrix protein production" RELATED [GOC:TermGenie]
is_obsolete: true
consider: GO:0010629
created_by: vk
creation_date: 2012-08-22T09:18:35Z

[Term]
id: GO:1901313
name: obsolete positive regulation of gene expression involved in extracellular matrix organization
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of gene expression involved in extracellular matrix organization." [GOC:BHF, GOC:TermGenie]
comment: This term was made obolete is that in these terms the 'involved in' process is not truly involved_in (i.e. part_of) the process but instead is causally upstream of it. We advise replacing annotations to these terms with annotations + extensions using the causally_upstream_of relation e.g. P1234 regulation of gene expression [causally_upstream_of] extracellular matrix organization.
synonym: "activation of expression of extracellular matrix proteins" EXACT [GOC:TermGenie]
synonym: "activation of extracellular matrix protein production" RELATED [GOC:TermGenie]
synonym: "activation of gene expression involved in extracellular matrix organization" NARROW [GOC:TermGenie]
synonym: "positive regulation of expression of extracellular matrix proteins" EXACT [GOC:TermGenie]
synonym: "positive regulation of extracellular matrix protein production" RELATED [GOC:TermGenie]
synonym: "up regulation of expression of extracellular matrix proteins" EXACT [GOC:TermGenie]
synonym: "up regulation of extracellular matrix protein production" RELATED [GOC:TermGenie]
synonym: "up regulation of gene expression involved in extracellular matrix organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of expression of extracellular matrix proteins" EXACT [GOC:TermGenie]
synonym: "up-regulation of extracellular matrix protein production" RELATED [GOC:TermGenie]
synonym: "up-regulation of gene expression involved in extracellular matrix organization" EXACT [GOC:TermGenie]
synonym: "upregulation of expression of extracellular matrix proteins" EXACT [GOC:TermGenie]
synonym: "upregulation of extracellular matrix protein production" RELATED [GOC:TermGenie]
synonym: "upregulation of gene expression involved in extracellular matrix organization" EXACT [GOC:TermGenie]
is_obsolete: true
consider: GO:0010628
created_by: vk
creation_date: 2012-08-22T09:18:42Z

[Term]
id: GO:1901314
name: regulation of histone H2A K63-linked ubiquitination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of histone H2A K63-linked ubiquitination." [GOC:TermGenie]
is_a: GO:0033182 ! regulation of histone ubiquitination
is_a: GO:1900044 ! regulation of protein K63-linked ubiquitination
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070535 ! histone H2A K63-linked ubiquitination
relationship: regulates GO:0070535 ! histone H2A K63-linked ubiquitination
created_by: tb
creation_date: 2012-08-22T20:29:04Z

[Term]
id: GO:1901315
name: negative regulation of histone H2A K63-linked ubiquitination
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone H2A K63-linked ubiquitination." [GOC:TermGenie]
synonym: "down regulation of histone H2A K63-linked ubiquitination" EXACT [GOC:TermGenie]
synonym: "down-regulation of histone H2A K63-linked ubiquitination" EXACT [GOC:TermGenie]
synonym: "downregulation of histone H2A K63-linked ubiquitination" EXACT [GOC:TermGenie]
synonym: "inhibition of histone H2A K63-linked ubiquitination" NARROW [GOC:TermGenie]
is_a: GO:0033183 ! negative regulation of histone ubiquitination
is_a: GO:1900045 ! negative regulation of protein K63-linked ubiquitination
is_a: GO:1901314 ! regulation of histone H2A K63-linked ubiquitination
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070535 ! histone H2A K63-linked ubiquitination
relationship: negatively_regulates GO:0070535 ! histone H2A K63-linked ubiquitination
created_by: tb
creation_date: 2012-08-22T20:29:24Z

[Term]
id: GO:1901316
name: positive regulation of histone H2A K63-linked ubiquitination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of histone H2A K63-linked ubiquitination." [GOC:TermGenie]
synonym: "activation of histone H2A K63-linked ubiquitination" NARROW [GOC:TermGenie]
synonym: "up regulation of histone H2A K63-linked ubiquitination" EXACT [GOC:TermGenie]
synonym: "up-regulation of histone H2A K63-linked ubiquitination" EXACT [GOC:TermGenie]
synonym: "upregulation of histone H2A K63-linked ubiquitination" EXACT [GOC:TermGenie]
is_a: GO:0033184 ! positive regulation of histone ubiquitination
is_a: GO:1901314 ! regulation of histone H2A K63-linked ubiquitination
is_a: GO:1902523 ! positive regulation of protein K63-linked ubiquitination
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070535 ! histone H2A K63-linked ubiquitination
relationship: positively_regulates GO:0070535 ! histone H2A K63-linked ubiquitination
created_by: tb
creation_date: 2012-08-22T20:29:32Z

[Term]
id: GO:1901317
name: regulation of sperm motility
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sperm motility." [GOC:TermGenie]
synonym: "regulation of sperm movement" EXACT [GOC:TermGenie]
is_a: GO:2000145 ! regulation of cell motility
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030317 ! sperm motility
relationship: regulates GO:0030317 ! sperm motility
created_by: hjd
creation_date: 2012-08-22T20:50:14Z

[Term]
id: GO:1901318
name: negative regulation of sperm motility
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sperm motility." [GOC:TermGenie]
synonym: "down regulation of sperm motility" EXACT [GOC:TermGenie]
synonym: "down regulation of sperm movement" EXACT [GOC:TermGenie]
synonym: "down-regulation of sperm motility" EXACT [GOC:TermGenie]
synonym: "down-regulation of sperm movement" EXACT [GOC:TermGenie]
synonym: "downregulation of sperm motility" EXACT [GOC:TermGenie]
synonym: "downregulation of sperm movement" EXACT [GOC:TermGenie]
synonym: "inhibition of sperm motility" NARROW [GOC:TermGenie]
synonym: "inhibition of sperm movement" EXACT [GOC:TermGenie]
synonym: "negative regulation of sperm movement" EXACT [GOC:TermGenie]
is_a: GO:1901317 ! regulation of sperm motility
is_a: GO:2000146 ! negative regulation of cell motility
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030317 ! sperm motility
relationship: negatively_regulates GO:0030317 ! sperm motility
created_by: hjd
creation_date: 2012-08-22T20:50:35Z

[Term]
id: GO:1901319
name: positive regulation of trehalose catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of trehalose catabolic process." [GOC:TermGenie]
synonym: "activation of mycose catabolic process" EXACT [GOC:TermGenie]
synonym: "activation of mycose catabolism" EXACT [GOC:TermGenie]
synonym: "activation of mykose catabolic process" EXACT [GOC:TermGenie]
synonym: "activation of mykose catabolism" EXACT [GOC:TermGenie]
synonym: "activation of trehalose breakdown" EXACT [GOC:TermGenie]
synonym: "activation of trehalose catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of trehalose catabolism" EXACT [GOC:TermGenie]
synonym: "activation of trehalose degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of mycose catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of mycose catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of mykose catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of mykose catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of trehalose breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of trehalose catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of trehalose degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of mycose catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of mycose catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of mykose catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of mykose catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of trehalose breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of trehalose catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of trehalose catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of trehalose degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of mycose catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of mycose catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of mykose catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of mykose catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of trehalose breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of trehalose catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of trehalose catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of trehalose degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of mycose catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of mycose catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of mykose catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of mykose catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of trehalose breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of trehalose catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of trehalose catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of trehalose degradation" EXACT [GOC:TermGenie]
is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process
is_a: GO:0090062 ! regulation of trehalose metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0005993 ! trehalose catabolic process
relationship: positively_regulates GO:0005993 ! trehalose catabolic process
created_by: al
creation_date: 2012-08-24T12:57:52Z

[Term]
id: GO:1901320
name: negative regulation of heart induction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of heart induction." [GOC:TermGenie]
synonym: "down regulation of heart induction" EXACT [GOC:TermGenie]
synonym: "down-regulation of heart induction" EXACT [GOC:TermGenie]
synonym: "downregulation of heart induction" EXACT [GOC:TermGenie]
synonym: "inhibition of heart induction" NARROW [GOC:TermGenie]
is_a: GO:0010454 ! negative regulation of cell fate commitment
is_a: GO:0010648 ! negative regulation of cell communication
is_a: GO:0023057 ! negative regulation of signaling
is_a: GO:0090381 ! regulation of heart induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003129 ! heart induction
relationship: negatively_regulates GO:0003129 ! heart induction
created_by: bf
creation_date: 2012-08-28T15:48:38Z

[Term]
id: GO:1901321
name: positive regulation of heart induction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of heart induction." [GOC:TermGenie]
synonym: "activation of heart induction" NARROW [GOC:TermGenie]
synonym: "up regulation of heart induction" EXACT [GOC:TermGenie]
synonym: "up-regulation of heart induction" EXACT [GOC:TermGenie]
synonym: "upregulation of heart induction" EXACT [GOC:TermGenie]
is_a: GO:0010455 ! positive regulation of cell fate commitment
is_a: GO:0010647 ! positive regulation of cell communication
is_a: GO:0023056 ! positive regulation of signaling
is_a: GO:0090381 ! regulation of heart induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003129 ! heart induction
relationship: positively_regulates GO:0003129 ! heart induction
created_by: bf
creation_date: 2012-08-28T15:49:51Z

[Term]
id: GO:1901322
name: response to chloramphenicol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chloramphenicol stimulus." [GOC:TermGenie]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: tb
creation_date: 2012-08-30T00:01:07Z

[Term]
id: GO:1901323
name: response to erythromycin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythromycin stimulus." [GOC:TermGenie]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: mah
creation_date: 2012-08-30T10:09:59Z

[Term]
id: GO:1901324
name: response to trichodermin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trichodermin stimulus." [GOC:TermGenie]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0045472 ! response to ether
created_by: mah
creation_date: 2012-08-30T10:11:07Z

[Term]
id: GO:1901325
name: response to antimycin A
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antimycin A stimulus." [GOC:TermGenie]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: mah
creation_date: 2012-08-30T10:12:16Z

[Term]
id: GO:1901326
name: response to tetracycline
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetracycline stimulus." [GOC:TermGenie]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: mah
creation_date: 2012-08-30T10:13:26Z

[Term]
id: GO:1901327
name: response to tacrolimus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tacrolimus stimulus." [GOC:TermGenie]
synonym: "response to FK506" EXACT [CHEBI:61057]
synonym: "response to tacrolimus hydrate" EXACT [CHEBI:61057]
is_a: GO:0042221 ! response to chemical
created_by: mah
creation_date: 2012-08-30T10:14:40Z

[Term]
id: GO:1901328
name: response to cytochalasin B
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytochalasin B stimulus." [GOC:TermGenie]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: mah
creation_date: 2012-08-30T16:36:35Z

[Term]
id: GO:1901329
name: regulation of odontoblast differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of odontoblast differentiation." [GOC:TermGenie]
is_a: GO:0030856 ! regulation of epithelial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071895 ! odontoblast differentiation
relationship: regulates GO:0071895 ! odontoblast differentiation
created_by: hjd
creation_date: 2012-08-31T16:50:05Z

[Term]
id: GO:1901330
name: negative regulation of odontoblast differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of odontoblast differentiation." [GOC:TermGenie]
synonym: "down regulation of odontoblast differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of odontoblast differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of odontoblast differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of odontoblast differentiation" NARROW [GOC:TermGenie]
is_a: GO:0002085 ! inhibition of neuroepithelial cell differentiation
is_a: GO:1901329 ! regulation of odontoblast differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071895 ! odontoblast differentiation
relationship: negatively_regulates GO:0071895 ! odontoblast differentiation
created_by: hjd
creation_date: 2012-08-31T16:50:27Z

[Term]
id: GO:1901331
name: positive regulation of odontoblast differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of odontoblast differentiation." [GOC:TermGenie]
synonym: "activation of odontoblast differentiation" NARROW [GOC:TermGenie]
synonym: "up regulation of odontoblast differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of odontoblast differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of odontoblast differentiation" EXACT [GOC:TermGenie]
is_a: GO:1901329 ! regulation of odontoblast differentiation
is_a: GO:1902913 ! positive regulation of neuroepithelial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071895 ! odontoblast differentiation
relationship: positively_regulates GO:0071895 ! odontoblast differentiation
created_by: hjd
creation_date: 2012-08-31T16:50:35Z

[Term]
id: GO:1901332
name: negative regulation of lateral root development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lateral root development." [GOC:TermGenie]
synonym: "down regulation of lateral root development" EXACT [GOC:TermGenie]
synonym: "down-regulation of lateral root development" EXACT [GOC:TermGenie]
synonym: "downregulation of lateral root development" EXACT [GOC:TermGenie]
synonym: "inhibition of lateral root development" NARROW [GOC:TermGenie]
is_a: GO:0048581 ! negative regulation of post-embryonic development
is_a: GO:2000023 ! regulation of lateral root development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048527 ! lateral root development
relationship: negatively_regulates GO:0048527 ! lateral root development
created_by: tb
creation_date: 2012-09-01T00:58:37Z

[Term]
id: GO:1901333
name: positive regulation of lateral root development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lateral root development." [GOC:TermGenie]
synonym: "activation of lateral root development" NARROW [GOC:TermGenie]
synonym: "up regulation of lateral root development" EXACT [GOC:TermGenie]
synonym: "up-regulation of lateral root development" EXACT [GOC:TermGenie]
synonym: "upregulation of lateral root development" EXACT [GOC:TermGenie]
is_a: GO:0048582 ! positive regulation of post-embryonic development
is_a: GO:2000023 ! regulation of lateral root development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048527 ! lateral root development
relationship: positively_regulates GO:0048527 ! lateral root development
created_by: tb
creation_date: 2012-09-01T00:59:46Z

[Term]
id: GO:1901334
name: lactone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lactone." [GOC:TermGenie]
synonym: "lactone metabolism" EXACT [GOC:TermGenie]
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
created_by: bf
creation_date: 2012-09-03T10:26:00Z

[Term]
id: GO:1901335
name: lactone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lactone." [GOC:TermGenie]
synonym: "lactone breakdown" EXACT [GOC:TermGenie]
synonym: "lactone catabolism" EXACT [GOC:TermGenie]
synonym: "lactone degradation" EXACT [GOC:TermGenie]
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1901334 ! lactone metabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
created_by: bf
creation_date: 2012-09-03T10:27:11Z

[Term]
id: GO:1901336
name: lactone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lactone." [GOC:TermGenie]
synonym: "lactone anabolism" EXACT [GOC:TermGenie]
synonym: "lactone biosynthesis" EXACT [GOC:TermGenie]
synonym: "lactone formation" EXACT [GOC:TermGenie]
synonym: "lactone synthesis" EXACT [GOC:TermGenie]
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:1901334 ! lactone metabolic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
created_by: bf
creation_date: 2012-09-03T10:27:29Z

[Term]
id: GO:1901337
name: thioester transport
namespace: biological_process
def: "The directed movement of a thioester into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:TermGenie]
is_a: GO:0071702 ! organic substance transport
is_a: GO:0072348 ! sulfur compound transport
created_by: bf
creation_date: 2012-09-03T13:14:44Z

[Term]
id: GO:1901338
name: catecholamine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with catecholamine." [GOC:TermGenie]
is_a: GO:0097159 ! organic cyclic compound binding
created_by: bf
creation_date: 2012-09-03T14:08:44Z

[Term]
id: GO:1901339
name: regulation of store-operated calcium channel activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of store-operated calcium channel activity." [GOC:TermGenie]
is_a: GO:1901019 ! regulation of calcium ion transmembrane transporter activity
is_a: GO:2001257 ! regulation of cation channel activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0015279 ! store-operated calcium channel activity
relationship: regulates GO:0015279 ! store-operated calcium channel activity
created_by: pr
creation_date: 2012-09-03T14:23:10Z

[Term]
id: GO:1901340
name: negative regulation of store-operated calcium channel activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of store-operated calcium channel activity." [GOC:TermGenie]
synonym: "down regulation of store-operated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of store-operated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of store-operated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "inhibition of store-operated calcium channel activity" NARROW [GOC:TermGenie]
is_a: GO:1901020 ! negative regulation of calcium ion transmembrane transporter activity
is_a: GO:1901339 ! regulation of store-operated calcium channel activity
is_a: GO:2001258 ! negative regulation of cation channel activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0015279 ! store-operated calcium channel activity
relationship: negatively_regulates GO:0015279 ! store-operated calcium channel activity
created_by: pr
creation_date: 2012-09-03T14:24:21Z

[Term]
id: GO:1901341
name: positive regulation of store-operated calcium channel activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of store-operated calcium channel activity." [GOC:TermGenie]
synonym: "activation of store-operated calcium channel activity" NARROW [GOC:TermGenie]
synonym: "up regulation of store-operated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of store-operated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of store-operated calcium channel activity" EXACT [GOC:TermGenie]
is_a: GO:1901021 ! positive regulation of calcium ion transmembrane transporter activity
is_a: GO:1901339 ! regulation of store-operated calcium channel activity
is_a: GO:2001259 ! positive regulation of cation channel activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0015279 ! store-operated calcium channel activity
relationship: positively_regulates GO:0015279 ! store-operated calcium channel activity
created_by: pr
creation_date: 2012-09-03T14:24:38Z

[Term]
id: GO:1901342
name: regulation of vasculature development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vasculature development." [GOC:TermGenie]
synonym: "regulation of vascular system development" RELATED [GOC:TermGenie]
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001944 ! vasculature development
relationship: regulates GO:0001944 ! vasculature development
created_by: bf
creation_date: 2012-09-06T09:16:15Z

[Term]
id: GO:1901343
name: negative regulation of vasculature development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vasculature development." [GOC:TermGenie]
synonym: "down regulation of vascular system development" RELATED [GOC:TermGenie]
synonym: "down regulation of vasculature development" EXACT [GOC:TermGenie]
synonym: "down-regulation of vascular system development" RELATED [GOC:TermGenie]
synonym: "down-regulation of vasculature development" EXACT [GOC:TermGenie]
synonym: "downregulation of vascular system development" RELATED [GOC:TermGenie]
synonym: "downregulation of vasculature development" EXACT [GOC:TermGenie]
synonym: "inhibition of vascular system development" RELATED [GOC:TermGenie]
synonym: "inhibition of vasculature development" NARROW [GOC:TermGenie]
synonym: "negative regulation of vascular system development" RELATED [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1901342 ! regulation of vasculature development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001944 ! vasculature development
relationship: negatively_regulates GO:0001944 ! vasculature development
created_by: bf
creation_date: 2012-09-06T09:17:24Z

[Term]
id: GO:1901344
name: response to leptomycin B
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptomycin B stimulus." [GOC:TermGenie]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0070542 ! response to fatty acid
created_by: mah
creation_date: 2012-09-07T13:20:47Z

[Term]
id: GO:1901345
name: response to L-thialysine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-thialysine stimulus." [GOC:TermGenie]
synonym: "response to thialysine" BROAD [GOC:mah]
is_a: GO:0043200 ! response to amino acid
created_by: mah
creation_date: 2012-09-07T13:22:49Z

[Term]
id: GO:1901346
name: negative regulation of vasculature development involved in avascular cornea development in camera-type eye
namespace: biological_process
def: "Any negative regulation of vasculature development that is involved in developing an avascular cornea of a camera-type eye." [GOC:TermGenie, GOC:uh, PMID:16849433, PMID:17051153]
synonym: "down regulation of vascular system development involved in avascular cornea development" RELATED [GOC:TermGenie]
synonym: "down regulation of vascular system development involved in avascular cornea development in camera-type eye" RELATED [GOC:TermGenie]
synonym: "down regulation of vasculature development involved in avascular cornea development" EXACT [GOC:TermGenie]
synonym: "down regulation of vasculature development involved in avascular cornea development in camera-type eye" EXACT [GOC:TermGenie]
synonym: "down-regulation of vascular system development involved in avascular cornea development" RELATED [GOC:TermGenie]
synonym: "down-regulation of vascular system development involved in avascular cornea development in camera-type eye" RELATED [GOC:TermGenie]
synonym: "down-regulation of vasculature development involved in avascular cornea development" EXACT [GOC:TermGenie]
synonym: "down-regulation of vasculature development involved in avascular cornea development in camera-type eye" EXACT [GOC:TermGenie]
synonym: "downregulation of vascular system development involved in avascular cornea development" RELATED [GOC:TermGenie]
synonym: "downregulation of vascular system development involved in avascular cornea development in camera-type eye" RELATED [GOC:TermGenie]
synonym: "downregulation of vasculature development involved in avascular cornea development" EXACT [GOC:TermGenie]
synonym: "downregulation of vasculature development involved in avascular cornea development in camera-type eye" EXACT [GOC:TermGenie]
synonym: "inhibition of vascular system development involved in avascular cornea development" RELATED [GOC:TermGenie]
synonym: "inhibition of vascular system development involved in avascular cornea development in camera-type eye" RELATED [GOC:TermGenie]
synonym: "inhibition of vasculature development involved in avascular cornea development" NARROW [GOC:TermGenie]
synonym: "inhibition of vasculature development involved in avascular cornea development in camera-type eye" NARROW [GOC:TermGenie]
synonym: "negative regulation of vascular system development involved in avascular cornea development" RELATED [GOC:TermGenie]
synonym: "negative regulation of vascular system development involved in avascular cornea development in camera-type eye" RELATED [GOC:TermGenie]
synonym: "negative regulation of vasculature development involved in avascular cornea development" EXACT [GOC:TermGenie]
is_a: GO:1901343 ! negative regulation of vasculature development
intersection_of: GO:1901343 ! negative regulation of vasculature development
intersection_of: part_of GO:0036331 ! avascular cornea development in camera-type eye
relationship: part_of GO:0036331 ! avascular cornea development in camera-type eye
created_by: bf
creation_date: 2012-09-07T15:53:40Z

[Term]
id: GO:1901347
name: negative regulation of secondary cell wall biogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of secondary cell wall biogenesis." [GOC:TermGenie]
synonym: "down regulation of cellulose and pectin-containing secondary cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of plant-type secondary cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of secondary cell wall anabolism" BROAD [GOC:TermGenie]
synonym: "down regulation of secondary cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of secondary cell wall biosynthetic process" BROAD [GOC:TermGenie]
synonym: "down regulation of secondary cell wall formation" BROAD [GOC:TermGenie]
synonym: "down regulation of secondary cell wall synthesis" BROAD [GOC:TermGenie]
synonym: "down-regulation of cellulose and pectin-containing secondary cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of plant-type secondary cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of secondary cell wall anabolism" BROAD [GOC:TermGenie]
synonym: "down-regulation of secondary cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of secondary cell wall biosynthetic process" BROAD [GOC:TermGenie]
synonym: "down-regulation of secondary cell wall formation" BROAD [GOC:TermGenie]
synonym: "down-regulation of secondary cell wall synthesis" BROAD [GOC:TermGenie]
synonym: "downregulation of cellulose and pectin-containing secondary cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of plant-type secondary cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of secondary cell wall anabolism" BROAD [GOC:TermGenie]
synonym: "downregulation of secondary cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of secondary cell wall biosynthetic process" BROAD [GOC:TermGenie]
synonym: "downregulation of secondary cell wall formation" BROAD [GOC:TermGenie]
synonym: "downregulation of secondary cell wall synthesis" BROAD [GOC:TermGenie]
synonym: "inhibition of cellulose and pectin-containing secondary cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of plant-type secondary cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of secondary cell wall anabolism" BROAD [GOC:TermGenie]
synonym: "inhibition of secondary cell wall biogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of secondary cell wall biosynthetic process" BROAD [GOC:TermGenie]
synonym: "inhibition of secondary cell wall formation" BROAD [GOC:TermGenie]
synonym: "inhibition of secondary cell wall synthesis" BROAD [GOC:TermGenie]
synonym: "negative regulation of cellulose and pectin-containing secondary cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of plant-type secondary cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of secondary cell wall anabolism" BROAD [GOC:TermGenie]
synonym: "negative regulation of secondary cell wall biosynthetic process" BROAD [GOC:TermGenie]
synonym: "negative regulation of secondary cell wall formation" BROAD [GOC:TermGenie]
synonym: "negative regulation of secondary cell wall synthesis" BROAD [GOC:TermGenie]
is_a: GO:1903339 ! negative regulation of cell wall organization or biogenesis
is_a: GO:2000652 ! regulation of secondary cell wall biogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009834 ! plant-type secondary cell wall biogenesis
relationship: negatively_regulates GO:0009834 ! plant-type secondary cell wall biogenesis
created_by: tb
creation_date: 2012-09-07T17:58:05Z

[Term]
id: GO:1901348
name: positive regulation of secondary cell wall biogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of secondary cell wall biogenesis." [GOC:TermGenie]
synonym: "activation of cellulose and pectin-containing secondary cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "activation of plant-type secondary cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "activation of secondary cell wall anabolism" BROAD [GOC:TermGenie]
synonym: "activation of secondary cell wall biogenesis" NARROW [GOC:TermGenie]
synonym: "activation of secondary cell wall biosynthetic process" BROAD [GOC:TermGenie]
synonym: "activation of secondary cell wall formation" BROAD [GOC:TermGenie]
synonym: "activation of secondary cell wall synthesis" BROAD [GOC:TermGenie]
synonym: "positive regulation of cellulose and pectin-containing secondary cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of plant-type secondary cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of secondary cell wall anabolism" BROAD [GOC:TermGenie]
synonym: "positive regulation of secondary cell wall biosynthetic process" BROAD [GOC:TermGenie]
synonym: "positive regulation of secondary cell wall formation" BROAD [GOC:TermGenie]
synonym: "positive regulation of secondary cell wall synthesis" BROAD [GOC:TermGenie]
synonym: "up regulation of cellulose and pectin-containing secondary cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of plant-type secondary cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of secondary cell wall anabolism" BROAD [GOC:TermGenie]
synonym: "up regulation of secondary cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of secondary cell wall biosynthetic process" BROAD [GOC:TermGenie]
synonym: "up regulation of secondary cell wall formation" BROAD [GOC:TermGenie]
synonym: "up regulation of secondary cell wall synthesis" BROAD [GOC:TermGenie]
synonym: "up-regulation of cellulose and pectin-containing secondary cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of plant-type secondary cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of secondary cell wall anabolism" BROAD [GOC:TermGenie]
synonym: "up-regulation of secondary cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of secondary cell wall biosynthetic process" BROAD [GOC:TermGenie]
synonym: "up-regulation of secondary cell wall formation" BROAD [GOC:TermGenie]
synonym: "up-regulation of secondary cell wall synthesis" BROAD [GOC:TermGenie]
synonym: "upregulation of cellulose and pectin-containing secondary cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of plant-type secondary cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of secondary cell wall anabolism" BROAD [GOC:TermGenie]
synonym: "upregulation of secondary cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of secondary cell wall biosynthetic process" BROAD [GOC:TermGenie]
synonym: "upregulation of secondary cell wall formation" BROAD [GOC:TermGenie]
synonym: "upregulation of secondary cell wall synthesis" BROAD [GOC:TermGenie]
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:1903340 ! positive regulation of cell wall organization or biogenesis
is_a: GO:2000652 ! regulation of secondary cell wall biogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009834 ! plant-type secondary cell wall biogenesis
relationship: positively_regulates GO:0009834 ! plant-type secondary cell wall biogenesis
created_by: tb
creation_date: 2012-09-07T17:59:14Z

[Term]
id: GO:1901349
name: glucosinolate transport
namespace: biological_process
def: "The directed movement of a glucosinolate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:TermGenie]
is_a: GO:0015711 ! organic anion transport
is_a: GO:0072348 ! sulfur compound transport
is_a: GO:1901264 ! carbohydrate derivative transport
created_by: tb
creation_date: 2012-09-07T22:44:34Z

[Term]
id: GO:1901350
name: cell-cell signaling involved in cell-cell junction organization
namespace: biological_process
def: "Any cell-cell signaling that is involved in cell-cell junction organization." [GOC:TermGenie]
synonym: "cell-cell signaling involved in cell-cell junction assembly and maintenance" EXACT [GOC:TermGenie]
synonym: "cell-cell signaling involved in cell-cell junction biogenesis" RELATED [GOC:TermGenie]
synonym: "cell-cell signaling involved in cell-cell junction organisation" EXACT [GOC:TermGenie]
synonym: "cell-cell signaling involved in intercellular junction assembly and maintenance" EXACT [GOC:TermGenie]
synonym: "cell-cell signalling involved in cell-cell junction assembly and maintenance" EXACT [GOC:TermGenie]
synonym: "cell-cell signalling involved in cell-cell junction biogenesis" RELATED [GOC:TermGenie]
synonym: "cell-cell signalling involved in cell-cell junction organisation" EXACT [GOC:TermGenie]
synonym: "cell-cell signalling involved in cell-cell junction organization" EXACT [GOC:TermGenie]
synonym: "cell-cell signalling involved in intercellular junction assembly and maintenance" EXACT [GOC:TermGenie]
is_a: GO:0007267 ! cell-cell signaling
intersection_of: GO:0007267 ! cell-cell signaling
intersection_of: part_of GO:0045216 ! cell-cell junction organization
relationship: part_of GO:0045216 ! cell-cell junction organization
created_by: rph
creation_date: 2012-09-11T09:15:04Z

[Term]
id: GO:1901351
name: regulation of phosphatidylglycerol biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phosphatidylglycerol biosynthetic process." [GOC:dgf, GOC:TermGenie, PMID:12869188]
synonym: "regulation of phosphatidylglycerol anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of phosphatidylglycerol biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of phosphatidylglycerol formation" EXACT [GOC:TermGenie]
synonym: "regulation of phosphatidylglycerol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0071071 ! regulation of phospholipid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006655 ! phosphatidylglycerol biosynthetic process
relationship: regulates GO:0006655 ! phosphatidylglycerol biosynthetic process
created_by: dgf
creation_date: 2012-09-12T20:46:37Z

[Term]
id: GO:1901352
name: negative regulation of phosphatidylglycerol biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylglycerol biosynthetic process." [GOC:dgf, GOC:TermGenie, PMID:12869188]
synonym: "down regulation of phosphatidylglycerol anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphatidylglycerol biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphatidylglycerol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphatidylglycerol formation" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphatidylglycerol synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphatidylglycerol anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphatidylglycerol biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphatidylglycerol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphatidylglycerol formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphatidylglycerol synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphatidylglycerol anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphatidylglycerol biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphatidylglycerol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphatidylglycerol formation" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphatidylglycerol synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of phosphatidylglycerol anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of phosphatidylglycerol biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of phosphatidylglycerol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of phosphatidylglycerol formation" NARROW [GOC:TermGenie]
synonym: "inhibition of phosphatidylglycerol synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of phosphatidylglycerol anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphatidylglycerol biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphatidylglycerol formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphatidylglycerol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0071072 ! negative regulation of phospholipid biosynthetic process
is_a: GO:1901351 ! regulation of phosphatidylglycerol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006655 ! phosphatidylglycerol biosynthetic process
relationship: negatively_regulates GO:0006655 ! phosphatidylglycerol biosynthetic process
created_by: dgf
creation_date: 2012-09-12T20:47:53Z

[Term]
id: GO:1901353
name: positive regulation of phosphatidylglycerol biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phosphatidylglycerol biosynthetic process." [GOC:dgf, GOC:TermGenie, PMID:12869188]
synonym: "activation of phosphatidylglycerol anabolism" NARROW [GOC:TermGenie]
synonym: "activation of phosphatidylglycerol biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of phosphatidylglycerol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of phosphatidylglycerol formation" NARROW [GOC:TermGenie]
synonym: "activation of phosphatidylglycerol synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of phosphatidylglycerol anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphatidylglycerol biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphatidylglycerol formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphatidylglycerol synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphatidylglycerol anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphatidylglycerol biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphatidylglycerol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphatidylglycerol formation" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphatidylglycerol synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphatidylglycerol anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphatidylglycerol biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphatidylglycerol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphatidylglycerol formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphatidylglycerol synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphatidylglycerol anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphatidylglycerol biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphatidylglycerol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphatidylglycerol formation" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphatidylglycerol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0071073 ! positive regulation of phospholipid biosynthetic process
is_a: GO:1901351 ! regulation of phosphatidylglycerol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006655 ! phosphatidylglycerol biosynthetic process
relationship: positively_regulates GO:0006655 ! phosphatidylglycerol biosynthetic process
created_by: dgf
creation_date: 2012-09-12T20:48:11Z

[Term]
id: GO:1901354
name: response to L-canavanine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-canavanine stimulus." [GOC:TermGenie]
is_a: GO:0043200 ! response to amino acid
created_by: mah
creation_date: 2012-09-13T13:11:17Z

[Term]
id: GO:1901355
name: response to rapamycin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rapamycin stimulus." [GOC:TermGenie]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0045472 ! response to ether
is_a: GO:0097305 ! response to alcohol
is_a: GO:1901654 ! response to ketone
created_by: mah
creation_date: 2012-09-13T13:12:26Z

[Term]
id: GO:1901356
name: beta-D-galactofuranose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving beta-D-galactofuranose." [GOC:di, GOC:TermGenie]
synonym: "beta-D-galactofuranose metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006012 ! galactose metabolic process
created_by: di
creation_date: 2012-09-13T22:18:20Z

[Term]
id: GO:1901357
name: beta-D-galactofuranose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of beta-D-galactofuranose." [GOC:di, GOC:TermGenie]
synonym: "beta-D-galactofuranose breakdown" EXACT [GOC:TermGenie]
synonym: "beta-D-galactofuranose catabolism" EXACT [GOC:TermGenie]
synonym: "beta-D-galactofuranose degradation" EXACT [GOC:TermGenie]
is_a: GO:0019388 ! galactose catabolic process
is_a: GO:1901356 ! beta-D-galactofuranose metabolic process
created_by: di
creation_date: 2012-09-13T22:19:30Z

[Term]
id: GO:1901358
name: beta-D-galactofuranose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of beta-D-galactofuranose." [GOC:di, GOC:TermGenie]
synonym: "beta-D-galactofuranose anabolism" EXACT [GOC:TermGenie]
synonym: "beta-D-galactofuranose biosynthesis" EXACT [GOC:TermGenie]
synonym: "beta-D-galactofuranose formation" EXACT [GOC:TermGenie]
synonym: "beta-D-galactofuranose synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046369 ! galactose biosynthetic process
is_a: GO:1901356 ! beta-D-galactofuranose metabolic process
created_by: di
creation_date: 2012-09-13T22:19:47Z

[Term]
id: GO:1901359
name: tungstate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with tungstate." [GOC:TermGenie]
is_a: GO:0043168 ! anion binding
created_by: cdasilva
creation_date: 2012-09-14T08:33:56Z

[Term]
id: GO:1901360
name: organic cyclic compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving organic cyclic compound." [GOC:TermGenie]
synonym: "organic cyclic compound metabolism" EXACT [GOC:TermGenie]
is_a: GO:0071704 ! organic substance metabolic process
created_by: bf
creation_date: 2012-09-14T09:03:51Z

[Term]
id: GO:1901361
name: organic cyclic compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of organic cyclic compound." [GOC:TermGenie]
synonym: "organic cyclic compound breakdown" EXACT [GOC:TermGenie]
synonym: "organic cyclic compound catabolism" EXACT [GOC:TermGenie]
synonym: "organic cyclic compound degradation" EXACT [GOC:TermGenie]
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901575 ! organic substance catabolic process
created_by: bf
creation_date: 2012-09-14T09:05:04Z

[Term]
id: GO:1901362
name: organic cyclic compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of organic cyclic compound." [GOC:TermGenie]
synonym: "organic cyclic compound anabolism" EXACT [GOC:TermGenie]
synonym: "organic cyclic compound biosynthesis" EXACT [GOC:TermGenie]
synonym: "organic cyclic compound formation" EXACT [GOC:TermGenie]
synonym: "organic cyclic compound synthesis" EXACT [GOC:TermGenie]
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901576 ! organic substance biosynthetic process
created_by: bf
creation_date: 2012-09-14T09:05:22Z

[Term]
id: GO:1901363
name: heterocyclic compound binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with heterocyclic compound." [GOC:TermGenie]
is_a: GO:0005488 ! binding
created_by: bf
creation_date: 2012-09-14T13:53:50Z

[Term]
id: GO:1901364
name: funalenone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving funalenone." [GOC:di, GOC:TermGenie]
synonym: "funalenone metabolism" EXACT [GOC:TermGenie]
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0042180 ! cellular ketone metabolic process
created_by: di
creation_date: 2012-09-17T18:24:23Z

[Term]
id: GO:1901365
name: funalenone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of funalenone." [GOC:di, GOC:TermGenie]
synonym: "funalenone breakdown" EXACT [GOC:TermGenie]
synonym: "funalenone catabolism" EXACT [GOC:TermGenie]
synonym: "funalenone degradation" EXACT [GOC:TermGenie]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:1901364 ! funalenone metabolic process
created_by: di
creation_date: 2012-09-17T18:25:29Z

[Term]
id: GO:1901366
name: funalenone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of funalenone." [GOC:di, GOC:TermGenie]
synonym: "funalenone anabolism" EXACT [GOC:TermGenie]
synonym: "funalenone biosynthesis" EXACT [GOC:TermGenie]
synonym: "funalenone formation" EXACT [GOC:TermGenie]
synonym: "funalenone synthesis" EXACT [GOC:TermGenie]
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:1901364 ! funalenone metabolic process
created_by: di
creation_date: 2012-09-17T18:25:47Z

[Term]
id: GO:1901367
name: response to L-cysteine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-cysteine stimulus." [GOC:TermGenie]
is_a: GO:0043200 ! response to amino acid
created_by: bf
creation_date: 2012-09-18T13:49:42Z

[Term]
id: GO:1901368
name: NAD transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of NAD from one side of the membrane to the other." [GOC:TermGenie]
synonym: "nicotinamide adenine dinucleotide transmembrane transporter activity" EXACT []
synonym: "oxidized nicotinamide adenine dinucleotide transmembrane transporter activity" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide transmembrane transporter activity" EXACT []
is_a: GO:0015215 ! nucleotide transmembrane transporter activity
is_a: GO:0051724 ! NAD transporter activity
relationship: part_of GO:0035352 ! NAD transmembrane transport
created_by: jl
creation_date: 2012-09-19T13:21:08Z

[Term]
id: GO:1901369
name: cyclic 2,3-bisphospho-D-glycerate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cyclic 2,3-bisphospho-D-glyceric acid." [GOC:bf, GOC:crds, GOC:TermGenie, PMID:2226838]
synonym: "cDPG biosynthesis" EXACT [PMID:2226838]
synonym: "cyclic 2,3-bisphospho-D-glyceric acid anabolism" EXACT [GOC:TermGenie]
synonym: "cyclic 2,3-bisphospho-D-glyceric acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "cyclic 2,3-bisphospho-D-glyceric acid biosynthetic process" EXACT [CHEBI:28699]
synonym: "cyclic 2,3-bisphospho-D-glyceric acid formation" EXACT [GOC:TermGenie]
synonym: "cyclic 2,3-bisphospho-D-glyceric acid synthesis" EXACT [GOC:TermGenie]
synonym: "cyclic 2,3-diphosphoglycerate biosynthesis" EXACT [CHEBI:28699]
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0046175 ! aldonic acid biosynthetic process
is_a: GO:0090407 ! organophosphate biosynthetic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process
created_by: bf
creation_date: 2012-09-19T14:17:57Z

[Term]
id: GO:1901370
name: response to glutathione
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glutathione stimulus." [GOC:TermGenie]
is_a: GO:1901652 ! response to peptide
created_by: mah
creation_date: 2012-09-21T13:59:24Z

[Term]
id: GO:1901371
name: regulation of leaf morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of leaf morphogenesis." [GOC:TermGenie]
is_a: GO:1900618 ! regulation of shoot system morphogenesis
is_a: GO:2000024 ! regulation of leaf development
is_a: GO:2000027 ! regulation of organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009965 ! leaf morphogenesis
relationship: regulates GO:0009965 ! leaf morphogenesis
created_by: tb
creation_date: 2012-09-24T23:07:17Z

[Term]
id: GO:1901372
name: trehalose biosynthetic process involved in ascospore formation
namespace: biological_process
def: "Any trehalose biosynthetic process that is involved in ascospore formation." [GOC:TermGenie]
synonym: "mycose biosynthesis involved in ascospore biosynthesis" EXACT [GOC:TermGenie]
synonym: "mycose biosynthesis involved in ascospore formation" EXACT [GOC:TermGenie]
synonym: "mycose biosynthetic process involved in ascospore biosynthesis" EXACT [GOC:TermGenie]
synonym: "mycose biosynthetic process involved in ascospore formation" EXACT [GOC:TermGenie]
synonym: "mykose biosynthesis involved in ascospore biosynthesis" EXACT [GOC:TermGenie]
synonym: "mykose biosynthesis involved in ascospore formation" EXACT [GOC:TermGenie]
synonym: "mykose biosynthetic process involved in ascospore biosynthesis" EXACT [GOC:TermGenie]
synonym: "mykose biosynthetic process involved in ascospore formation" EXACT [GOC:TermGenie]
synonym: "trehalose anabolism involved in ascospore biosynthesis" EXACT [GOC:TermGenie]
synonym: "trehalose anabolism involved in ascospore formation" EXACT [GOC:TermGenie]
synonym: "trehalose biosynthesis involved in ascospore biosynthesis" EXACT [GOC:TermGenie]
synonym: "trehalose biosynthesis involved in ascospore formation" EXACT [GOC:TermGenie]
synonym: "trehalose biosynthetic process involved in ascospore biosynthesis" EXACT [GOC:TermGenie]
synonym: "trehalose formation involved in ascospore biosynthesis" EXACT [GOC:TermGenie]
synonym: "trehalose formation involved in ascospore formation" EXACT [GOC:TermGenie]
synonym: "trehalose synthesis involved in ascospore biosynthesis" EXACT [GOC:TermGenie]
synonym: "trehalose synthesis involved in ascospore formation" EXACT [GOC:TermGenie]
is_a: GO:0005992 ! trehalose biosynthetic process
is_a: GO:1903046 ! meiotic cell cycle process
intersection_of: GO:0005992 ! trehalose biosynthetic process
intersection_of: part_of GO:0030437 ! ascospore formation
relationship: part_of GO:0030437 ! ascospore formation
created_by: al
creation_date: 2012-09-25T11:06:48Z

[Term]
id: GO:1901373
name: lipid hydroperoxide transport
namespace: biological_process
def: "The directed movement of a lipid hydroperoxide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:TermGenie]
is_a: GO:0044765 ! single-organism transport
is_a: GO:0071702 ! organic substance transport
created_by: tb
creation_date: 2012-09-28T00:24:39Z

[Term]
id: GO:1901374
name: acetate ester transport
namespace: biological_process
def: "The directed movement of an acetate ester into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:TermGenie]
is_a: GO:0044765 ! single-organism transport
is_a: GO:0071702 ! organic substance transport
created_by: bf
creation_date: 2012-09-28T10:42:13Z

[Term]
id: GO:1901375
name: acetate ester transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of an acetate ester from one side of the membrane to the other." [GOC:TermGenie]
is_a: GO:0022857 ! transmembrane transporter activity
relationship: part_of GO:1901374 ! acetate ester transport
created_by: bf
creation_date: 2012-09-28T10:47:08Z

[Term]
id: GO:1901376
name: organic heteropentacyclic compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving organic heteropentacyclic compound." [GOC:TermGenie]
synonym: "organic heteropentacyclic compound metabolism" EXACT [GOC:TermGenie]
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
created_by: bf
creation_date: 2012-09-28T12:50:41Z

[Term]
id: GO:1901377
name: organic heteropentacyclic compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of organic heteropentacyclic compound." [GOC:TermGenie]
synonym: "organic heteropentacyclic compound breakdown" EXACT [GOC:TermGenie]
synonym: "organic heteropentacyclic compound catabolism" EXACT [GOC:TermGenie]
synonym: "organic heteropentacyclic compound degradation" EXACT [GOC:TermGenie]
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901376 ! organic heteropentacyclic compound metabolic process
created_by: bf
creation_date: 2012-09-28T12:51:51Z

[Term]
id: GO:1901378
name: organic heteropentacyclic compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of organic heteropentacyclic compound." [GOC:TermGenie]
synonym: "organic heteropentacyclic compound anabolism" EXACT [GOC:TermGenie]
synonym: "organic heteropentacyclic compound biosynthesis" EXACT [GOC:TermGenie]
synonym: "organic heteropentacyclic compound formation" EXACT [GOC:TermGenie]
synonym: "organic heteropentacyclic compound synthesis" EXACT [GOC:TermGenie]
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901376 ! organic heteropentacyclic compound metabolic process
created_by: bf
creation_date: 2012-09-28T12:52:09Z

[Term]
id: GO:1901379
name: regulation of potassium ion transmembrane transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of potassium ion transmembrane transport." [GOC:BHF, GOC:TermGenie]
synonym: "regulation of potassium ion membrane transport" EXACT []
is_a: GO:0043266 ! regulation of potassium ion transport
is_a: GO:1904062 ! regulation of cation transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071805 ! potassium ion transmembrane transport
relationship: regulates GO:0071805 ! potassium ion transmembrane transport
created_by: rl
creation_date: 2012-09-28T15:58:00Z

[Term]
id: GO:1901380
name: negative regulation of potassium ion transmembrane transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion transmembrane transport." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of potassium ion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of potassium ion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "downregulation of potassium ion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "inhibition of potassium ion transmembrane transport" NARROW [GOC:TermGenie]
synonym: "negative regulation of potassium ion membrane transport" EXACT []
is_a: GO:0043267 ! negative regulation of potassium ion transport
is_a: GO:1901379 ! regulation of potassium ion transmembrane transport
is_a: GO:1904063 ! negative regulation of cation transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071805 ! potassium ion transmembrane transport
relationship: negatively_regulates GO:0071805 ! potassium ion transmembrane transport
created_by: rl
creation_date: 2012-09-28T15:59:08Z

[Term]
id: GO:1901381
name: positive regulation of potassium ion transmembrane transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of potassium ion transmembrane transport." [GOC:BHF, GOC:TermGenie]
synonym: "activation of potassium ion transmembrane transport" NARROW [GOC:TermGenie]
synonym: "positive regulation of potassium ion membrane transport" EXACT []
synonym: "up regulation of potassium ion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of potassium ion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "upregulation of potassium ion transmembrane transport" EXACT [GOC:TermGenie]
is_a: GO:0043268 ! positive regulation of potassium ion transport
is_a: GO:1901379 ! regulation of potassium ion transmembrane transport
is_a: GO:1904064 ! positive regulation of cation transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071805 ! potassium ion transmembrane transport
relationship: positively_regulates GO:0071805 ! potassium ion transmembrane transport
created_by: rl
creation_date: 2012-09-28T15:59:25Z

[Term]
id: GO:1901382
name: regulation of chorionic trophoblast cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chorionic trophoblast cell proliferation." [GOC:BHF, GOC:TermGenie]
is_a: GO:0042127 ! regulation of cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097360 ! chorionic trophoblast cell proliferation
relationship: regulates GO:0097360 ! chorionic trophoblast cell proliferation
created_by: vk
creation_date: 2012-10-01T10:03:13Z

[Term]
id: GO:1901383
name: negative regulation of chorionic trophoblast cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chorionic trophoblast cell proliferation." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of chorionic trophoblast cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of chorionic trophoblast cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of chorionic trophoblast cell proliferation" EXACT [GOC:TermGenie]
synonym: "inhibition of chorionic trophoblast cell proliferation" NARROW [GOC:TermGenie]
is_a: GO:0008285 ! negative regulation of cell proliferation
is_a: GO:1901382 ! regulation of chorionic trophoblast cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097360 ! chorionic trophoblast cell proliferation
relationship: negatively_regulates GO:0097360 ! chorionic trophoblast cell proliferation
created_by: vk
creation_date: 2012-10-01T10:04:23Z

[Term]
id: GO:1901384
name: positive regulation of chorionic trophoblast cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chorionic trophoblast cell proliferation." [GOC:BHF, GOC:TermGenie]
synonym: "activation of chorionic trophoblast cell proliferation" NARROW [GOC:TermGenie]
synonym: "up regulation of chorionic trophoblast cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of chorionic trophoblast cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of chorionic trophoblast cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0008284 ! positive regulation of cell proliferation
is_a: GO:1901382 ! regulation of chorionic trophoblast cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097360 ! chorionic trophoblast cell proliferation
relationship: positively_regulates GO:0097360 ! chorionic trophoblast cell proliferation
created_by: vk
creation_date: 2012-10-01T10:04:41Z

[Term]
id: GO:1901385
name: regulation of voltage-gated calcium channel activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of voltage-gated calcium channel activity." [GOC:BHF, GOC:TermGenie]
synonym: "regulation of depolarization-activated calcium channel" BROAD [GOC:TermGenie]
synonym: "regulation of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "regulation of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie]
synonym: "regulation of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "regulation of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie]
synonym: "regulation of voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "regulation of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie]
synonym: "regulation of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie]
synonym: "regulation of voltage-sensitive calcium channel" EXACT [GOC:TermGenie]
is_a: GO:1901019 ! regulation of calcium ion transmembrane transporter activity
is_a: GO:2001257 ! regulation of cation channel activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0005245 ! voltage-gated calcium channel activity
relationship: regulates GO:0005245 ! voltage-gated calcium channel activity
created_by: vk
creation_date: 2012-10-01T10:34:08Z

[Term]
id: GO:1901386
name: negative regulation of voltage-gated calcium channel activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated calcium channel activity." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of depolarization-activated calcium channel" BROAD [GOC:TermGenie]
synonym: "down regulation of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie]
synonym: "down regulation of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie]
synonym: "down regulation of voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of voltage-gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of voltage-sensitive calcium channel" EXACT [GOC:TermGenie]
synonym: "down-regulation of depolarization-activated calcium channel" BROAD [GOC:TermGenie]
synonym: "down-regulation of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie]
synonym: "down-regulation of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of voltage-gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of voltage-sensitive calcium channel" EXACT [GOC:TermGenie]
synonym: "downregulation of depolarization-activated calcium channel" BROAD [GOC:TermGenie]
synonym: "downregulation of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie]
synonym: "downregulation of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie]
synonym: "downregulation of voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of voltage-gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of voltage-sensitive calcium channel" EXACT [GOC:TermGenie]
synonym: "inhibition of depolarization-activated calcium channel" BROAD [GOC:TermGenie]
synonym: "inhibition of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "inhibition of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie]
synonym: "inhibition of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "inhibition of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie]
synonym: "inhibition of voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "inhibition of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie]
synonym: "inhibition of voltage-gated calcium channel activity" NARROW [GOC:TermGenie]
synonym: "inhibition of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie]
synonym: "inhibition of voltage-sensitive calcium channel" EXACT [GOC:TermGenie]
synonym: "negative regulation of depolarization-activated calcium channel" BROAD [GOC:TermGenie]
synonym: "negative regulation of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie]
synonym: "negative regulation of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of voltage-sensitive calcium channel" EXACT [GOC:TermGenie]
is_a: GO:1901020 ! negative regulation of calcium ion transmembrane transporter activity
is_a: GO:1901385 ! regulation of voltage-gated calcium channel activity
is_a: GO:2001258 ! negative regulation of cation channel activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0005245 ! voltage-gated calcium channel activity
relationship: negatively_regulates GO:0005245 ! voltage-gated calcium channel activity
created_by: vk
creation_date: 2012-10-01T10:35:15Z

[Term]
id: GO:1901387
name: positive regulation of voltage-gated calcium channel activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of voltage-gated calcium channel activity." [GOC:BHF, GOC:TermGenie]
synonym: "activation of depolarization-activated calcium channel" BROAD [GOC:TermGenie]
synonym: "activation of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "activation of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie]
synonym: "activation of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "activation of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie]
synonym: "activation of voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "activation of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie]
synonym: "activation of voltage-gated calcium channel activity" NARROW [GOC:TermGenie]
synonym: "activation of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie]
synonym: "activation of voltage-sensitive calcium channel" EXACT [GOC:TermGenie]
synonym: "positive regulation of depolarization-activated calcium channel" BROAD [GOC:TermGenie]
synonym: "positive regulation of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie]
synonym: "positive regulation of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of voltage-sensitive calcium channel" EXACT [GOC:TermGenie]
synonym: "up regulation of depolarization-activated calcium channel" BROAD [GOC:TermGenie]
synonym: "up regulation of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie]
synonym: "up regulation of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie]
synonym: "up regulation of voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of voltage-gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of voltage-sensitive calcium channel" EXACT [GOC:TermGenie]
synonym: "up-regulation of depolarization-activated calcium channel" BROAD [GOC:TermGenie]
synonym: "up-regulation of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie]
synonym: "up-regulation of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of voltage-gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of voltage-sensitive calcium channel" EXACT [GOC:TermGenie]
synonym: "upregulation of depolarization-activated calcium channel" BROAD [GOC:TermGenie]
synonym: "upregulation of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie]
synonym: "upregulation of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie]
synonym: "upregulation of voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of voltage-gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of voltage-sensitive calcium channel" EXACT [GOC:TermGenie]
is_a: GO:1901021 ! positive regulation of calcium ion transmembrane transporter activity
is_a: GO:1901385 ! regulation of voltage-gated calcium channel activity
is_a: GO:2001259 ! positive regulation of cation channel activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0005245 ! voltage-gated calcium channel activity
relationship: positively_regulates GO:0005245 ! voltage-gated calcium channel activity
created_by: vk
creation_date: 2012-10-01T10:35:32Z

[Term]
id: GO:1901388
name: regulation of transforming growth factor beta activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transforming growth factor beta activation." [GOC:sl, GOC:TermGenie]
synonym: "regulation of L-TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "regulation of latent TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "regulation of TGF-B activation" EXACT [GOC:TermGenie]
synonym: "regulation of TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "regulation of TGFB activation" EXACT [GOC:TermGenie]
synonym: "regulation of TGFbeta activation" EXACT [GOC:TermGenie]
is_a: GO:0071634 ! regulation of transforming growth factor beta production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0036363 ! transforming growth factor beta activation
relationship: regulates GO:0036363 ! transforming growth factor beta activation
created_by: bf
creation_date: 2012-10-01T10:32:00Z

[Term]
id: GO:1901389
name: negative regulation of transforming growth factor beta activation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of transforming growth factor beta activation." [GOC:sl, GOC:TermGenie]
synonym: "down regulation of L-TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "down regulation of latent TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "down regulation of TGF-B activation" EXACT [GOC:TermGenie]
synonym: "down regulation of TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "down regulation of TGFB activation" EXACT [GOC:TermGenie]
synonym: "down regulation of TGFbeta activation" EXACT [GOC:TermGenie]
synonym: "down regulation of transforming growth factor beta activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of L-TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of latent TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of TGF-B activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of TGFB activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of TGFbeta activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of transforming growth factor beta activation" EXACT [GOC:TermGenie]
synonym: "downregulation of L-TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "downregulation of latent TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "downregulation of TGF-B activation" EXACT [GOC:TermGenie]
synonym: "downregulation of TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "downregulation of TGFB activation" EXACT [GOC:TermGenie]
synonym: "downregulation of TGFbeta activation" EXACT [GOC:TermGenie]
synonym: "downregulation of transforming growth factor beta activation" EXACT [GOC:TermGenie]
synonym: "inhibition of L-TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "inhibition of latent TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "inhibition of TGF-B activation" EXACT [GOC:TermGenie]
synonym: "inhibition of TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "inhibition of TGFB activation" EXACT [GOC:TermGenie]
synonym: "inhibition of TGFbeta activation" EXACT [GOC:TermGenie]
synonym: "inhibition of transforming growth factor beta activation" NARROW [GOC:TermGenie]
synonym: "negative regulation of L-TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "negative regulation of latent TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "negative regulation of TGF-B activation" EXACT [GOC:TermGenie]
synonym: "negative regulation of TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "negative regulation of TGFB activation" EXACT [GOC:TermGenie]
synonym: "negative regulation of TGFbeta activation" EXACT [GOC:TermGenie]
is_a: GO:0071635 ! negative regulation of transforming growth factor beta production
is_a: GO:1901388 ! regulation of transforming growth factor beta activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0036363 ! transforming growth factor beta activation
relationship: negatively_regulates GO:0036363 ! transforming growth factor beta activation
created_by: bf
creation_date: 2012-10-01T10:33:09Z

[Term]
id: GO:1901390
name: positive regulation of transforming growth factor beta activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transforming growth factor beta activation." [GOC:sl, GOC:TermGenie]
synonym: "activation of L-TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "activation of latent TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "activation of TGF-B activation" EXACT [GOC:TermGenie]
synonym: "activation of TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "activation of TGFB activation" EXACT [GOC:TermGenie]
synonym: "activation of TGFbeta activation" EXACT [GOC:TermGenie]
synonym: "activation of transforming growth factor beta activation" NARROW [GOC:TermGenie]
synonym: "positive regulation of L-TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "positive regulation of latent TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "positive regulation of TGF-B activation" EXACT [GOC:TermGenie]
synonym: "positive regulation of TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "positive regulation of TGFB activation" EXACT [GOC:TermGenie]
synonym: "positive regulation of TGFbeta activation" EXACT [GOC:TermGenie]
synonym: "up regulation of L-TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "up regulation of latent TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "up regulation of TGF-B activation" EXACT [GOC:TermGenie]
synonym: "up regulation of TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "up regulation of TGFB activation" EXACT [GOC:TermGenie]
synonym: "up regulation of TGFbeta activation" EXACT [GOC:TermGenie]
synonym: "up regulation of transforming growth factor beta activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of latent TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of TGF-B activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of TGFB activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of TGFbeta activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of transforming growth factor beta activation" EXACT [GOC:TermGenie]
synonym: "upregulation of L-TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "upregulation of latent TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "upregulation of TGF-B activation" EXACT [GOC:TermGenie]
synonym: "upregulation of TGF-beta activation" EXACT [GOC:TermGenie]
synonym: "upregulation of TGFB activation" EXACT [GOC:TermGenie]
synonym: "upregulation of TGFbeta activation" EXACT [GOC:TermGenie]
synonym: "upregulation of transforming growth factor beta activation" EXACT [GOC:TermGenie]
is_a: GO:0071636 ! positive regulation of transforming growth factor beta production
is_a: GO:1901388 ! regulation of transforming growth factor beta activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0036363 ! transforming growth factor beta activation
relationship: positively_regulates GO:0036363 ! transforming growth factor beta activation
created_by: bf
creation_date: 2012-10-01T10:33:26Z

[Term]
id: GO:1901392
name: regulation of transforming growth factor beta1 activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transforming growth factor beta1 activation." [GOC:sl, GOC:TermGenie]
synonym: "regulation of L-TGF-beta 1 activation" EXACT [GOC:TermGenie]
synonym: "regulation of latent-TGF-beta1 activation" EXACT [GOC:TermGenie]
synonym: "regulation of TGF-beta 1 activation" EXACT [GOC:TermGenie]
synonym: "regulation of TGFB1 activation" EXACT [GOC:TermGenie]
synonym: "regulation of TGFbeta 1 activation" EXACT [GOC:TermGenie]
synonym: "regulation of transforming growth factor-beta1 activation" EXACT [GOC:TermGenie]
is_a: GO:0032908 ! regulation of transforming growth factor beta1 production
is_a: GO:1901388 ! regulation of transforming growth factor beta activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0036364 ! transforming growth factor beta1 activation
relationship: regulates GO:0036364 ! transforming growth factor beta1 activation
created_by: bf
creation_date: 2012-10-01T10:40:06Z

[Term]
id: GO:1901393
name: negative regulation of transforming growth factor beta1 activation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of transforming growth factor beta1 activation." [GOC:sl, GOC:TermGenie]
synonym: "down regulation of L-TGF-beta 1 activation" EXACT [GOC:TermGenie]
synonym: "down regulation of latent-TGF-beta1 activation" EXACT [GOC:TermGenie]
synonym: "down regulation of TGF-beta 1 activation" EXACT [GOC:TermGenie]
synonym: "down regulation of TGFB1 activation" EXACT [GOC:TermGenie]
synonym: "down regulation of TGFbeta 1 activation" EXACT [GOC:TermGenie]
synonym: "down regulation of transforming growth factor beta1 activation" EXACT [GOC:TermGenie]
synonym: "down regulation of transforming growth factor-beta1 activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of L-TGF-beta 1 activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of latent-TGF-beta1 activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of TGF-beta 1 activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of TGFB1 activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of TGFbeta 1 activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of transforming growth factor beta1 activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of transforming growth factor-beta1 activation" EXACT [GOC:TermGenie]
synonym: "downregulation of L-TGF-beta 1 activation" EXACT [GOC:TermGenie]
synonym: "downregulation of latent-TGF-beta1 activation" EXACT [GOC:TermGenie]
synonym: "downregulation of TGF-beta 1 activation" EXACT [GOC:TermGenie]
synonym: "downregulation of TGFB1 activation" EXACT [GOC:TermGenie]
synonym: "downregulation of TGFbeta 1 activation" EXACT [GOC:TermGenie]
synonym: "downregulation of transforming growth factor beta1 activation" EXACT [GOC:TermGenie]
synonym: "downregulation of transforming growth factor-beta1 activation" EXACT [GOC:TermGenie]
synonym: "inhibition of L-TGF-beta 1 activation" EXACT [GOC:TermGenie]
synonym: "inhibition of latent-TGF-beta1 activation" EXACT [GOC:TermGenie]
synonym: "inhibition of TGF-beta 1 activation" EXACT [GOC:TermGenie]
synonym: "inhibition of TGFB1 activation" EXACT [GOC:TermGenie]
synonym: "inhibition of TGFbeta 1 activation" EXACT [GOC:TermGenie]
synonym: "inhibition of transforming growth factor beta1 activation" NARROW [GOC:TermGenie]
synonym: "inhibition of transforming growth factor-beta1 activation" EXACT [GOC:TermGenie]
synonym: "negative regulation of L-TGF-beta 1 activation" EXACT [GOC:TermGenie]
synonym: "negative regulation of latent-TGF-beta1 activation" EXACT [GOC:TermGenie]
synonym: "negative regulation of TGF-beta 1 activation" EXACT [GOC:TermGenie]
synonym: "negative regulation of TGFB1 activation" EXACT [GOC:TermGenie]
synonym: "negative regulation of TGFbeta 1 activation" EXACT [GOC:TermGenie]
synonym: "negative regulation of transforming growth factor-beta1 activation" EXACT [GOC:TermGenie]
is_a: GO:0032911 ! negative regulation of transforming growth factor beta1 production
is_a: GO:1901389 ! negative regulation of transforming growth factor beta activation
is_a: GO:1901392 ! regulation of transforming growth factor beta1 activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0036364 ! transforming growth factor beta1 activation
relationship: negatively_regulates GO:0036364 ! transforming growth factor beta1 activation
created_by: bf
creation_date: 2012-10-01T10:41:17Z

[Term]
id: GO:1901394
name: positive regulation of transforming growth factor beta1 activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transforming growth factor beta1 activation." [GOC:sl, GOC:TermGenie]
synonym: "activation of L-TGF-beta 1 activation" EXACT [GOC:TermGenie]
synonym: "activation of latent-TGF-beta1 activation" EXACT [GOC:TermGenie]
synonym: "activation of TGF-beta 1 activation" EXACT [GOC:TermGenie]
synonym: "activation of TGFB1 activation" EXACT [GOC:TermGenie]
synonym: "activation of TGFbeta 1 activation" EXACT [GOC:TermGenie]
synonym: "activation of transforming growth factor beta1 activation" NARROW [GOC:TermGenie]
synonym: "activation of transforming growth factor-beta1 activation" EXACT [GOC:TermGenie]
synonym: "positive regulation of L-TGF-beta 1 activation" EXACT [GOC:TermGenie]
synonym: "positive regulation of latent-TGF-beta1 activation" EXACT [GOC:TermGenie]
synonym: "positive regulation of TGF-beta 1 activation" EXACT [GOC:TermGenie]
synonym: "positive regulation of TGFB1 activation" EXACT [GOC:TermGenie]
synonym: "positive regulation of TGFbeta 1 activation" EXACT [GOC:TermGenie]
synonym: "positive regulation of transforming growth factor-beta1 activation" EXACT [GOC:TermGenie]
synonym: "up regulation of L-TGF-beta 1 activation" EXACT [GOC:TermGenie]
synonym: "up regulation of latent-TGF-beta1 activation" EXACT [GOC:TermGenie]
synonym: "up regulation of TGF-beta 1 activation" EXACT [GOC:TermGenie]
synonym: "up regulation of TGFB1 activation" EXACT [GOC:TermGenie]
synonym: "up regulation of TGFbeta 1 activation" EXACT [GOC:TermGenie]
synonym: "up regulation of transforming growth factor beta1 activation" EXACT [GOC:TermGenie]
synonym: "up regulation of transforming growth factor-beta1 activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-TGF-beta 1 activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of latent-TGF-beta1 activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of TGF-beta 1 activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of TGFB1 activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of TGFbeta 1 activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of transforming growth factor beta1 activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of transforming growth factor-beta1 activation" EXACT [GOC:TermGenie]
synonym: "upregulation of L-TGF-beta 1 activation" EXACT [GOC:TermGenie]
synonym: "upregulation of latent-TGF-beta1 activation" EXACT [GOC:TermGenie]
synonym: "upregulation of TGF-beta 1 activation" EXACT [GOC:TermGenie]
synonym: "upregulation of TGFB1 activation" EXACT [GOC:TermGenie]
synonym: "upregulation of TGFbeta 1 activation" EXACT [GOC:TermGenie]
synonym: "upregulation of transforming growth factor beta1 activation" EXACT [GOC:TermGenie]
synonym: "upregulation of transforming growth factor-beta1 activation" EXACT [GOC:TermGenie]
is_a: GO:0032914 ! positive regulation of transforming growth factor beta1 production
is_a: GO:1901390 ! positive regulation of transforming growth factor beta activation
is_a: GO:1901392 ! regulation of transforming growth factor beta1 activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0036364 ! transforming growth factor beta1 activation
relationship: positively_regulates GO:0036364 ! transforming growth factor beta1 activation
created_by: bf
creation_date: 2012-10-01T10:41:33Z

[Term]
id: GO:1901395
name: regulation of transforming growth factor beta2 activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transforming growth factor beta2 activation." [GOC:sl, GOC:TermGenie]
synonym: "regulation of TGF-beta 2 activation" EXACT [GOC:TermGenie]
synonym: "regulation of TGFB2 activation" EXACT [GOC:TermGenie]
synonym: "regulation of TGFbeta 2 activation" EXACT [GOC:TermGenie]
is_a: GO:0032909 ! regulation of transforming growth factor beta2 production
is_a: GO:1901388 ! regulation of transforming growth factor beta activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0036365 ! transforming growth factor beta2 activation
relationship: regulates GO:0036365 ! transforming growth factor beta2 activation
created_by: bf
creation_date: 2012-10-01T10:46:50Z

[Term]
id: GO:1901396
name: negative regulation of transforming growth factor beta2 activation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of transforming growth factor beta2 activation." [GOC:sl, GOC:TermGenie]
synonym: "down regulation of TGF-beta 2 activation" EXACT [GOC:TermGenie]
synonym: "down regulation of TGFB2 activation" EXACT [GOC:TermGenie]
synonym: "down regulation of TGFbeta 2 activation" EXACT [GOC:TermGenie]
synonym: "down regulation of transforming growth factor beta2 activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of TGF-beta 2 activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of TGFB2 activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of TGFbeta 2 activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of transforming growth factor beta2 activation" EXACT [GOC:TermGenie]
synonym: "downregulation of TGF-beta 2 activation" EXACT [GOC:TermGenie]
synonym: "downregulation of TGFB2 activation" EXACT [GOC:TermGenie]
synonym: "downregulation of TGFbeta 2 activation" EXACT [GOC:TermGenie]
synonym: "downregulation of transforming growth factor beta2 activation" EXACT [GOC:TermGenie]
synonym: "inhibition of TGF-beta 2 activation" EXACT [GOC:TermGenie]
synonym: "inhibition of TGFB2 activation" EXACT [GOC:TermGenie]
synonym: "inhibition of TGFbeta 2 activation" EXACT [GOC:TermGenie]
synonym: "inhibition of transforming growth factor beta2 activation" NARROW [GOC:TermGenie]
synonym: "negative regulation of TGF-beta 2 activation" EXACT [GOC:TermGenie]
synonym: "negative regulation of TGFB2 activation" EXACT [GOC:TermGenie]
synonym: "negative regulation of TGFbeta 2 activation" EXACT [GOC:TermGenie]
is_a: GO:0032912 ! negative regulation of transforming growth factor beta2 production
is_a: GO:1901389 ! negative regulation of transforming growth factor beta activation
is_a: GO:1901395 ! regulation of transforming growth factor beta2 activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0036365 ! transforming growth factor beta2 activation
relationship: negatively_regulates GO:0036365 ! transforming growth factor beta2 activation
created_by: bf
creation_date: 2012-10-01T10:47:59Z

[Term]
id: GO:1901397
name: positive regulation of transforming growth factor beta2 activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transforming growth factor beta2 activation." [GOC:sl, GOC:TermGenie]
synonym: "activation of TGF-beta 2 activation" EXACT [GOC:TermGenie]
synonym: "activation of TGFB2 activation" EXACT [GOC:TermGenie]
synonym: "activation of TGFbeta 2 activation" EXACT [GOC:TermGenie]
synonym: "activation of transforming growth factor beta2 activation" NARROW [GOC:TermGenie]
synonym: "positive regulation of TGF-beta 2 activation" EXACT [GOC:TermGenie]
synonym: "positive regulation of TGFB2 activation" EXACT [GOC:TermGenie]
synonym: "positive regulation of TGFbeta 2 activation" EXACT [GOC:TermGenie]
synonym: "up regulation of TGF-beta 2 activation" EXACT [GOC:TermGenie]
synonym: "up regulation of TGFB2 activation" EXACT [GOC:TermGenie]
synonym: "up regulation of TGFbeta 2 activation" EXACT [GOC:TermGenie]
synonym: "up regulation of transforming growth factor beta2 activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of TGF-beta 2 activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of TGFB2 activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of TGFbeta 2 activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of transforming growth factor beta2 activation" EXACT [GOC:TermGenie]
synonym: "upregulation of TGF-beta 2 activation" EXACT [GOC:TermGenie]
synonym: "upregulation of TGFB2 activation" EXACT [GOC:TermGenie]
synonym: "upregulation of TGFbeta 2 activation" EXACT [GOC:TermGenie]
synonym: "upregulation of transforming growth factor beta2 activation" EXACT [GOC:TermGenie]
is_a: GO:0032915 ! positive regulation of transforming growth factor beta2 production
is_a: GO:1901390 ! positive regulation of transforming growth factor beta activation
is_a: GO:1901395 ! regulation of transforming growth factor beta2 activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0036365 ! transforming growth factor beta2 activation
relationship: positively_regulates GO:0036365 ! transforming growth factor beta2 activation
created_by: bf
creation_date: 2012-10-01T10:48:15Z

[Term]
id: GO:1901398
name: regulation of transforming growth factor beta3 activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transforming growth factor beta3 activation." [GOC:sl, GOC:TermGenie]
synonym: "regulation of TGF-beta 3 activation" EXACT [GOC:TermGenie]
synonym: "regulation of TGFB3 activation" EXACT [GOC:TermGenie]
synonym: "regulation of TGFbeta 3 activation" EXACT [GOC:TermGenie]
is_a: GO:0032910 ! regulation of transforming growth factor beta3 production
is_a: GO:1901388 ! regulation of transforming growth factor beta activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0036366 ! transforming growth factor beta3 activation
relationship: regulates GO:0036366 ! transforming growth factor beta3 activation
created_by: bf
creation_date: 2012-10-01T10:49:25Z

[Term]
id: GO:1901399
name: negative regulation of transforming growth factor beta3 activation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of transforming growth factor beta3 activation." [GOC:sl, GOC:TermGenie]
synonym: "down regulation of TGF-beta 3 activation" EXACT [GOC:TermGenie]
synonym: "down regulation of TGFB3 activation" EXACT [GOC:TermGenie]
synonym: "down regulation of TGFbeta 3 activation" EXACT [GOC:TermGenie]
synonym: "down regulation of transforming growth factor beta3 activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of TGF-beta 3 activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of TGFB3 activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of TGFbeta 3 activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of transforming growth factor beta3 activation" EXACT [GOC:TermGenie]
synonym: "downregulation of TGF-beta 3 activation" EXACT [GOC:TermGenie]
synonym: "downregulation of TGFB3 activation" EXACT [GOC:TermGenie]
synonym: "downregulation of TGFbeta 3 activation" EXACT [GOC:TermGenie]
synonym: "downregulation of transforming growth factor beta3 activation" EXACT [GOC:TermGenie]
synonym: "inhibition of TGF-beta 3 activation" EXACT [GOC:TermGenie]
synonym: "inhibition of TGFB3 activation" EXACT [GOC:TermGenie]
synonym: "inhibition of TGFbeta 3 activation" EXACT [GOC:TermGenie]
synonym: "inhibition of transforming growth factor beta3 activation" NARROW [GOC:TermGenie]
synonym: "negative regulation of TGF-beta 3 activation" EXACT [GOC:TermGenie]
synonym: "negative regulation of TGFB3 activation" EXACT [GOC:TermGenie]
synonym: "negative regulation of TGFbeta 3 activation" EXACT [GOC:TermGenie]
is_a: GO:0032913 ! negative regulation of transforming growth factor beta3 production
is_a: GO:1901389 ! negative regulation of transforming growth factor beta activation
is_a: GO:1901398 ! regulation of transforming growth factor beta3 activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0036366 ! transforming growth factor beta3 activation
relationship: negatively_regulates GO:0036366 ! transforming growth factor beta3 activation
created_by: bf
creation_date: 2012-10-01T10:50:32Z

[Term]
id: GO:1901400
name: positive regulation of transforming growth factor beta3 activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transforming growth factor beta3 activation." [GOC:sl, GOC:TermGenie]
synonym: "activation of TGF-beta 3 activation" EXACT [GOC:TermGenie]
synonym: "activation of TGFB3 activation" EXACT [GOC:TermGenie]
synonym: "activation of TGFbeta 3 activation" EXACT [GOC:TermGenie]
synonym: "activation of transforming growth factor beta3 activation" NARROW [GOC:TermGenie]
synonym: "positive regulation of TGF-beta 3 activation" EXACT [GOC:TermGenie]
synonym: "positive regulation of TGFB3 activation" EXACT [GOC:TermGenie]
synonym: "positive regulation of TGFbeta 3 activation" EXACT [GOC:TermGenie]
synonym: "up regulation of TGF-beta 3 activation" EXACT [GOC:TermGenie]
synonym: "up regulation of TGFB3 activation" EXACT [GOC:TermGenie]
synonym: "up regulation of TGFbeta 3 activation" EXACT [GOC:TermGenie]
synonym: "up regulation of transforming growth factor beta3 activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of TGF-beta 3 activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of TGFB3 activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of TGFbeta 3 activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of transforming growth factor beta3 activation" EXACT [GOC:TermGenie]
synonym: "upregulation of TGF-beta 3 activation" EXACT [GOC:TermGenie]
synonym: "upregulation of TGFB3 activation" EXACT [GOC:TermGenie]
synonym: "upregulation of TGFbeta 3 activation" EXACT [GOC:TermGenie]
synonym: "upregulation of transforming growth factor beta3 activation" EXACT [GOC:TermGenie]
is_a: GO:0032916 ! positive regulation of transforming growth factor beta3 production
is_a: GO:1901390 ! positive regulation of transforming growth factor beta activation
is_a: GO:1901398 ! regulation of transforming growth factor beta3 activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0036366 ! transforming growth factor beta3 activation
relationship: positively_regulates GO:0036366 ! transforming growth factor beta3 activation
created_by: bf
creation_date: 2012-10-01T10:50:49Z

[Term]
id: GO:1901401
name: regulation of tetrapyrrole metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tetrapyrrole metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie]
is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0033013 ! tetrapyrrole metabolic process
relationship: regulates GO:0033013 ! tetrapyrrole metabolic process
created_by: tt
creation_date: 2012-10-01T14:34:03Z

[Term]
id: GO:1901402
name: negative regulation of tetrapyrrole metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of tetrapyrrole metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetrapyrrole metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of tetrapyrrole metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of tetrapyrrole metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of tetrapyrrole metabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie]
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process
is_a: GO:1901401 ! regulation of tetrapyrrole metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0033013 ! tetrapyrrole metabolic process
relationship: negatively_regulates GO:0033013 ! tetrapyrrole metabolic process
created_by: tt
creation_date: 2012-10-01T14:35:11Z

[Term]
id: GO:1901403
name: positive regulation of tetrapyrrole metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tetrapyrrole metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of tetrapyrrole metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of tetrapyrrole metabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of tetrapyrrole metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetrapyrrole metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of tetrapyrrole metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie]
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process
is_a: GO:1901401 ! regulation of tetrapyrrole metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0033013 ! tetrapyrrole metabolic process
relationship: positively_regulates GO:0033013 ! tetrapyrrole metabolic process
created_by: tt
creation_date: 2012-10-01T14:35:29Z

[Term]
id: GO:1901404
name: regulation of tetrapyrrole catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tetrapyrrole catabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of tetrapyrrole degradation" EXACT [GOC:TermGenie]
is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:1901401 ! regulation of tetrapyrrole metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0033015 ! tetrapyrrole catabolic process
relationship: regulates GO:0033015 ! tetrapyrrole catabolic process
created_by: tt
creation_date: 2012-10-01T14:38:12Z

[Term]
id: GO:1901405
name: negative regulation of tetrapyrrole catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole catabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of tetrapyrrole catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of tetrapyrrole degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetrapyrrole catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetrapyrrole degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of tetrapyrrole catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of tetrapyrrole degradation" EXACT [GOC:TermGenie]
synonym: "inhibition of tetrapyrrole breakdown" EXACT [GOC:TermGenie]
synonym: "inhibition of tetrapyrrole catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of tetrapyrrole catabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of tetrapyrrole degradation" EXACT [GOC:TermGenie]
synonym: "negative regulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of tetrapyrrole degradation" EXACT [GOC:TermGenie]
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:1901402 ! negative regulation of tetrapyrrole metabolic process
is_a: GO:1901404 ! regulation of tetrapyrrole catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0033015 ! tetrapyrrole catabolic process
relationship: negatively_regulates GO:0033015 ! tetrapyrrole catabolic process
created_by: tt
creation_date: 2012-10-01T14:39:22Z

[Term]
id: GO:1901406
name: positive regulation of tetrapyrrole catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tetrapyrrole catabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of tetrapyrrole breakdown" EXACT [GOC:TermGenie]
synonym: "activation of tetrapyrrole catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of tetrapyrrole catabolism" EXACT [GOC:TermGenie]
synonym: "activation of tetrapyrrole degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of tetrapyrrole degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of tetrapyrrole catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of tetrapyrrole degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetrapyrrole catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetrapyrrole degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of tetrapyrrole catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of tetrapyrrole degradation" EXACT [GOC:TermGenie]
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:1901403 ! positive regulation of tetrapyrrole metabolic process
is_a: GO:1901404 ! regulation of tetrapyrrole catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0033015 ! tetrapyrrole catabolic process
relationship: positively_regulates GO:0033015 ! tetrapyrrole catabolic process
created_by: tt
creation_date: 2012-10-01T14:39:40Z

[Term]
id: GO:1901407
name: regulation of phosphorylation of RNA polymerase II C-terminal domain
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phosphorylation of RNA polymerase II C-terminal domain." [GOC:TermGenie]
synonym: "regulation of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "regulation of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "regulation of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "regulation of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie]
is_a: GO:0001932 ! regulation of protein phosphorylation
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070816 ! phosphorylation of RNA polymerase II C-terminal domain
relationship: regulates GO:0070816 ! phosphorylation of RNA polymerase II C-terminal domain
created_by: vw
creation_date: 2012-10-01T14:39:50Z

[Term]
id: GO:1901408
name: negative regulation of phosphorylation of RNA polymerase II C-terminal domain
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of phosphorylation of RNA polymerase II C-terminal domain." [GOC:TermGenie]
synonym: "down regulation of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "down regulation of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "down regulation of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "down regulation of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie]
synonym: "down-regulation of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "down-regulation of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "down-regulation of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "down-regulation of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie]
synonym: "downregulation of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "downregulation of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "downregulation of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "downregulation of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie]
synonym: "inhibition of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "inhibition of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "inhibition of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "inhibition of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie]
synonym: "inhibition of phosphorylation of RNA polymerase II C-terminal domain" NARROW [GOC:TermGenie]
synonym: "negative regulation of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "negative regulation of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "negative regulation of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "negative regulation of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie]
is_a: GO:0001933 ! negative regulation of protein phosphorylation
is_a: GO:1901407 ! regulation of phosphorylation of RNA polymerase II C-terminal domain
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070816 ! phosphorylation of RNA polymerase II C-terminal domain
relationship: negatively_regulates GO:0070816 ! phosphorylation of RNA polymerase II C-terminal domain
created_by: vw
creation_date: 2012-10-01T14:40:58Z

[Term]
id: GO:1901409
name: positive regulation of phosphorylation of RNA polymerase II C-terminal domain
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phosphorylation of RNA polymerase II C-terminal domain." [GOC:TermGenie]
synonym: "activation of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "activation of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "activation of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "activation of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie]
synonym: "activation of phosphorylation of RNA polymerase II C-terminal domain" NARROW [GOC:TermGenie]
synonym: "positive regulation of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "positive regulation of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "positive regulation of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "positive regulation of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie]
synonym: "up regulation of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "up regulation of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "up regulation of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "up regulation of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie]
synonym: "up-regulation of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "up-regulation of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "up-regulation of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "up-regulation of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie]
synonym: "upregulation of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "upregulation of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "upregulation of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "upregulation of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie]
is_a: GO:0001934 ! positive regulation of protein phosphorylation
is_a: GO:1901407 ! regulation of phosphorylation of RNA polymerase II C-terminal domain
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070816 ! phosphorylation of RNA polymerase II C-terminal domain
relationship: positively_regulates GO:0070816 ! phosphorylation of RNA polymerase II C-terminal domain
created_by: vw
creation_date: 2012-10-01T14:41:15Z

[Term]
id: GO:1901410
name: regulation of tetrapyrrole biosynthetic process from glutamate
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tetrapyrrole biosynthetic process from glutamate." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie]
synonym: "regulation of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie]
synonym: "regulation of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie]
synonym: "regulation of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie]
is_a: GO:1901463 ! regulation of tetrapyrrole biosynthetic process
is_a: GO:2000211 ! regulation of glutamate metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0033526 ! tetrapyrrole biosynthetic process from glutamate
relationship: regulates GO:0033526 ! tetrapyrrole biosynthetic process from glutamate
created_by: tt
creation_date: 2012-10-01T16:20:56Z

[Term]
id: GO:1901411
name: negative regulation of tetrapyrrole biosynthetic process from glutamate
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole biosynthetic process from glutamate." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie]
synonym: "down regulation of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie]
synonym: "down regulation of tetrapyrrole biosynthetic process from glutamate" EXACT [GOC:TermGenie]
synonym: "down regulation of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie]
synonym: "down regulation of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetrapyrrole biosynthetic process from glutamate" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie]
synonym: "downregulation of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie]
synonym: "downregulation of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie]
synonym: "downregulation of tetrapyrrole biosynthetic process from glutamate" EXACT [GOC:TermGenie]
synonym: "downregulation of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie]
synonym: "downregulation of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie]
synonym: "inhibition of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie]
synonym: "inhibition of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie]
synonym: "inhibition of tetrapyrrole biosynthetic process from glutamate" NARROW [GOC:TermGenie]
synonym: "inhibition of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie]
synonym: "inhibition of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie]
synonym: "negative regulation of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie]
synonym: "negative regulation of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie]
synonym: "negative regulation of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie]
synonym: "negative regulation of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie]
is_a: GO:1901410 ! regulation of tetrapyrrole biosynthetic process from glutamate
is_a: GO:1901464 ! negative regulation of tetrapyrrole biosynthetic process
is_a: GO:2000212 ! negative regulation of glutamate metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0033526 ! tetrapyrrole biosynthetic process from glutamate
relationship: negatively_regulates GO:0033526 ! tetrapyrrole biosynthetic process from glutamate
created_by: tt
creation_date: 2012-10-01T16:22:03Z

[Term]
id: GO:1901412
name: positive regulation of tetrapyrrole biosynthetic process from glutamate
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tetrapyrrole biosynthetic process from glutamate." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie]
synonym: "activation of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie]
synonym: "activation of tetrapyrrole biosynthetic process from glutamate" NARROW [GOC:TermGenie]
synonym: "activation of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie]
synonym: "activation of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie]
synonym: "positive regulation of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie]
synonym: "positive regulation of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie]
synonym: "positive regulation of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie]
synonym: "positive regulation of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie]
synonym: "up regulation of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie]
synonym: "up regulation of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie]
synonym: "up regulation of tetrapyrrole biosynthetic process from glutamate" EXACT [GOC:TermGenie]
synonym: "up regulation of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie]
synonym: "up regulation of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetrapyrrole biosynthetic process from glutamate" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie]
synonym: "upregulation of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie]
synonym: "upregulation of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie]
synonym: "upregulation of tetrapyrrole biosynthetic process from glutamate" EXACT [GOC:TermGenie]
synonym: "upregulation of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie]
synonym: "upregulation of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie]
is_a: GO:1901410 ! regulation of tetrapyrrole biosynthetic process from glutamate
is_a: GO:1901465 ! positive regulation of tetrapyrrole biosynthetic process
is_a: GO:2000213 ! positive regulation of glutamate metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0033526 ! tetrapyrrole biosynthetic process from glutamate
relationship: positively_regulates GO:0033526 ! tetrapyrrole biosynthetic process from glutamate
created_by: tt
creation_date: 2012-10-01T16:22:21Z

[Term]
id: GO:1901413
name: regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tetrapyrrole biosynthetic process from glycine and succinyl-CoA." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of tetrapyrrole anabolism from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "regulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "regulation of tetrapyrrole formation from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "regulation of tetrapyrrole synthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
is_a: GO:0006521 ! regulation of cellular amino acid metabolic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
is_a: GO:0051174 ! regulation of phosphorus metabolic process
is_a: GO:0051196 ! regulation of coenzyme metabolic process
is_a: GO:1901463 ! regulation of tetrapyrrole biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0033527 ! tetrapyrrole biosynthetic process from glycine and succinyl-CoA
relationship: regulates GO:0033527 ! tetrapyrrole biosynthetic process from glycine and succinyl-CoA
created_by: tt
creation_date: 2012-10-01T16:27:43Z

[Term]
id: GO:1901414
name: negative regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole biosynthetic process from glycine and succinyl-CoA." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of tetrapyrrole anabolism from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "down regulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "down regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "down regulation of tetrapyrrole formation from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "down regulation of tetrapyrrole synthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetrapyrrole anabolism from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetrapyrrole formation from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetrapyrrole synthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "downregulation of tetrapyrrole anabolism from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "downregulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "downregulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "downregulation of tetrapyrrole formation from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "downregulation of tetrapyrrole synthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "inhibition of tetrapyrrole anabolism from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "inhibition of tetrapyrrole biosynthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "inhibition of tetrapyrrole biosynthetic process from glycine and succinyl-CoA" NARROW [GOC:TermGenie]
synonym: "inhibition of tetrapyrrole formation from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "inhibition of tetrapyrrole synthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "negative regulation of tetrapyrrole anabolism from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "negative regulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "negative regulation of tetrapyrrole formation from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "negative regulation of tetrapyrrole synthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
is_a: GO:0010563 ! negative regulation of phosphorus metabolic process
is_a: GO:0045763 ! negative regulation of cellular amino acid metabolic process
is_a: GO:0051175 ! negative regulation of sulfur metabolic process
is_a: GO:0051198 ! negative regulation of coenzyme metabolic process
is_a: GO:1901413 ! regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA
is_a: GO:1901464 ! negative regulation of tetrapyrrole biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0033527 ! tetrapyrrole biosynthetic process from glycine and succinyl-CoA
relationship: negatively_regulates GO:0033527 ! tetrapyrrole biosynthetic process from glycine and succinyl-CoA
created_by: tt
creation_date: 2012-10-01T16:28:54Z

[Term]
id: GO:1901415
name: positive regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tetrapyrrole biosynthetic process from glycine and succinyl-CoA." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of tetrapyrrole anabolism from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "activation of tetrapyrrole biosynthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "activation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA" NARROW [GOC:TermGenie]
synonym: "activation of tetrapyrrole formation from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "activation of tetrapyrrole synthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "positive regulation of tetrapyrrole anabolism from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "positive regulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "positive regulation of tetrapyrrole formation from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "positive regulation of tetrapyrrole synthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "up regulation of tetrapyrrole anabolism from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "up regulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "up regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "up regulation of tetrapyrrole formation from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "up regulation of tetrapyrrole synthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetrapyrrole anabolism from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetrapyrrole formation from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetrapyrrole synthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "upregulation of tetrapyrrole anabolism from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "upregulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "upregulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "upregulation of tetrapyrrole formation from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "upregulation of tetrapyrrole synthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
is_a: GO:0010562 ! positive regulation of phosphorus metabolic process
is_a: GO:0045764 ! positive regulation of cellular amino acid metabolic process
is_a: GO:0051176 ! positive regulation of sulfur metabolic process
is_a: GO:0051197 ! positive regulation of coenzyme metabolic process
is_a: GO:1901413 ! regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA
is_a: GO:1901465 ! positive regulation of tetrapyrrole biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0033527 ! tetrapyrrole biosynthetic process from glycine and succinyl-CoA
relationship: positively_regulates GO:0033527 ! tetrapyrrole biosynthetic process from glycine and succinyl-CoA
created_by: tt
creation_date: 2012-10-01T16:29:12Z

[Term]
id: GO:1901416
name: regulation of response to ethanol
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to ethanol." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:1901419 ! regulation of response to alcohol
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045471 ! response to ethanol
relationship: regulates GO:0045471 ! response to ethanol
created_by: tt
creation_date: 2012-10-01T16:48:24Z

[Term]
id: GO:1901417
name: negative regulation of response to ethanol
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to ethanol." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of response to ethanol" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to ethanol" EXACT [GOC:TermGenie]
synonym: "downregulation of response to ethanol" EXACT [GOC:TermGenie]
synonym: "inhibition of response to ethanol" NARROW [GOC:TermGenie]
is_a: GO:1901416 ! regulation of response to ethanol
is_a: GO:1901420 ! negative regulation of response to alcohol
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045471 ! response to ethanol
relationship: negatively_regulates GO:0045471 ! response to ethanol
created_by: tt
creation_date: 2012-10-01T16:49:33Z

[Term]
id: GO:1901418
name: positive regulation of response to ethanol
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to ethanol." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of response to ethanol" NARROW [GOC:TermGenie]
synonym: "up regulation of response to ethanol" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to ethanol" EXACT [GOC:TermGenie]
synonym: "upregulation of response to ethanol" EXACT [GOC:TermGenie]
is_a: GO:1901416 ! regulation of response to ethanol
is_a: GO:1901421 ! positive regulation of response to alcohol
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045471 ! response to ethanol
relationship: positively_regulates GO:0045471 ! response to ethanol
created_by: tt
creation_date: 2012-10-01T16:49:51Z

[Term]
id: GO:1901419
name: regulation of response to alcohol
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to alcohol." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0048583 ! regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097305 ! response to alcohol
relationship: regulates GO:0097305 ! response to alcohol
created_by: tt
creation_date: 2012-10-01T16:52:13Z

[Term]
id: GO:1901420
name: negative regulation of response to alcohol
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to alcohol." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of response to alcohol" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to alcohol" EXACT [GOC:TermGenie]
synonym: "downregulation of response to alcohol" EXACT [GOC:TermGenie]
synonym: "inhibition of response to alcohol" NARROW [GOC:TermGenie]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1901419 ! regulation of response to alcohol
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097305 ! response to alcohol
relationship: negatively_regulates GO:0097305 ! response to alcohol
created_by: tt
creation_date: 2012-10-01T16:53:25Z

[Term]
id: GO:1901421
name: positive regulation of response to alcohol
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to alcohol." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of response to alcohol" NARROW [GOC:TermGenie]
synonym: "up regulation of response to alcohol" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to alcohol" EXACT [GOC:TermGenie]
synonym: "upregulation of response to alcohol" EXACT [GOC:TermGenie]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1901419 ! regulation of response to alcohol
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097305 ! response to alcohol
relationship: positively_regulates GO:0097305 ! response to alcohol
created_by: tt
creation_date: 2012-10-01T16:53:42Z

[Term]
id: GO:1901422
name: response to butan-1-ol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a butan-1-ol stimulus." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0001101 ! response to acid chemical
is_a: GO:0097305 ! response to alcohol
created_by: tt
creation_date: 2012-10-01T17:03:54Z

[Term]
id: GO:1901423
name: response to benzene
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benzene stimulus." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0014070 ! response to organic cyclic compound
created_by: tt
creation_date: 2012-10-01T18:35:11Z

[Term]
id: GO:1901424
name: response to toluene
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toluene stimulus." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0014070 ! response to organic cyclic compound
created_by: tt
creation_date: 2012-10-01T18:38:32Z

[Term]
id: GO:1901425
name: response to formic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a formic acid stimulus." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0001101 ! response to acid chemical
is_a: GO:0010033 ! response to organic substance
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: tt
creation_date: 2012-10-01T18:43:05Z

[Term]
id: GO:1901426
name: response to furfural
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a furfural stimulus." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: tt
creation_date: 2012-10-01T18:45:43Z

[Term]
id: GO:1901427
name: response to propan-1-ol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a propan-1-ol stimulus." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0001101 ! response to acid chemical
is_a: GO:0097305 ! response to alcohol
created_by: tt
creation_date: 2012-10-01T18:55:48Z

[Term]
id: GO:1901428
name: regulation of syringal lignin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of syringal lignin biosynthetic process." [GOC:TermGenie]
synonym: "regulation of S-lignin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "regulation of syringal lignin anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of syringal lignin biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of syringal lignin formation" EXACT [GOC:TermGenie]
synonym: "regulation of syringal lignin synthesis" EXACT [GOC:TermGenie]
is_a: GO:1901141 ! regulation of lignin biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1901066 ! syringal lignin biosynthetic process
relationship: regulates GO:1901066 ! syringal lignin biosynthetic process
created_by: tb
creation_date: 2012-10-01T20:13:41Z

[Term]
id: GO:1901429
name: negative regulation of syringal lignin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of syringal lignin biosynthetic process." [GOC:TermGenie]
synonym: "down regulation of S-lignin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of syringal lignin anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of syringal lignin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of syringal lignin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of syringal lignin formation" EXACT [GOC:TermGenie]
synonym: "down regulation of syringal lignin synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of S-lignin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of syringal lignin anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of syringal lignin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of syringal lignin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of syringal lignin formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of syringal lignin synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of S-lignin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of syringal lignin anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of syringal lignin biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of syringal lignin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of syringal lignin formation" EXACT [GOC:TermGenie]
synonym: "downregulation of syringal lignin synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of S-lignin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "inhibition of syringal lignin anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of syringal lignin biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of syringal lignin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of syringal lignin formation" EXACT [GOC:TermGenie]
synonym: "inhibition of syringal lignin synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of S-lignin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of syringal lignin anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of syringal lignin biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of syringal lignin formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of syringal lignin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1901428 ! regulation of syringal lignin biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1901066 ! syringal lignin biosynthetic process
relationship: negatively_regulates GO:1901066 ! syringal lignin biosynthetic process
created_by: tb
creation_date: 2012-10-01T20:14:51Z

[Term]
id: GO:1901430
name: positive regulation of syringal lignin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of syringal lignin biosynthetic process." [GOC:TermGenie]
synonym: "activation of S-lignin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "activation of syringal lignin anabolism" EXACT [GOC:TermGenie]
synonym: "activation of syringal lignin biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of syringal lignin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of syringal lignin formation" EXACT [GOC:TermGenie]
synonym: "activation of syringal lignin synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of S-lignin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of syringal lignin anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of syringal lignin biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of syringal lignin formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of syringal lignin synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of S-lignin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of syringal lignin anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of syringal lignin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of syringal lignin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of syringal lignin formation" EXACT [GOC:TermGenie]
synonym: "up regulation of syringal lignin synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of S-lignin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of syringal lignin anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of syringal lignin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of syringal lignin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of syringal lignin formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of syringal lignin synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of S-lignin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of syringal lignin anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of syringal lignin biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of syringal lignin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of syringal lignin formation" EXACT [GOC:TermGenie]
synonym: "upregulation of syringal lignin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1901428 ! regulation of syringal lignin biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1901066 ! syringal lignin biosynthetic process
relationship: positively_regulates GO:1901066 ! syringal lignin biosynthetic process
created_by: tb
creation_date: 2012-10-01T20:15:09Z

[Term]
id: GO:1901431
name: regulation of response to cycloalkane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to cycloalkane." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0048583 ! regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0014071 ! response to cycloalkane
relationship: regulates GO:0014071 ! response to cycloalkane
created_by: tt
creation_date: 2012-10-01T21:01:58Z

[Term]
id: GO:1901432
name: negative regulation of response to cycloalkane
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to cycloalkane." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of response to cycloalkane" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to cycloalkane" EXACT [GOC:TermGenie]
synonym: "downregulation of response to cycloalkane" EXACT [GOC:TermGenie]
synonym: "inhibition of response to cycloalkane" NARROW [GOC:TermGenie]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1901431 ! regulation of response to cycloalkane
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0014071 ! response to cycloalkane
relationship: negatively_regulates GO:0014071 ! response to cycloalkane
created_by: tt
creation_date: 2012-10-01T21:03:08Z

[Term]
id: GO:1901433
name: positive regulation of response to cycloalkane
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to cycloalkane." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of response to cycloalkane" NARROW [GOC:TermGenie]
synonym: "up regulation of response to cycloalkane" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to cycloalkane" EXACT [GOC:TermGenie]
synonym: "upregulation of response to cycloalkane" EXACT [GOC:TermGenie]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1901431 ! regulation of response to cycloalkane
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0014071 ! response to cycloalkane
relationship: positively_regulates GO:0014071 ! response to cycloalkane
created_by: tt
creation_date: 2012-10-01T21:03:26Z

[Term]
id: GO:1901434
name: regulation of toluene catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of toluene catabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of toluene breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of toluene catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of toluene degradation" EXACT [GOC:TermGenie]
is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:0048583 ! regulation of response to stimulus
is_a: GO:1901437 ! regulation of toluene metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042203 ! toluene catabolic process
relationship: regulates GO:0042203 ! toluene catabolic process
created_by: tt
creation_date: 2012-10-01T21:12:31Z

[Term]
id: GO:1901435
name: negative regulation of toluene catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of toluene catabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of toluene breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of toluene catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of toluene catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of toluene degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of toluene breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of toluene catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of toluene catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of toluene degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of toluene breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of toluene catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of toluene catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of toluene degradation" EXACT [GOC:TermGenie]
synonym: "inhibition of toluene breakdown" EXACT [GOC:TermGenie]
synonym: "inhibition of toluene catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of toluene catabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of toluene degradation" EXACT [GOC:TermGenie]
synonym: "negative regulation of toluene breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of toluene catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of toluene degradation" EXACT [GOC:TermGenie]
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1901434 ! regulation of toluene catabolic process
is_a: GO:1901438 ! negative regulation of toluene metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042203 ! toluene catabolic process
relationship: negatively_regulates GO:0042203 ! toluene catabolic process
created_by: tt
creation_date: 2012-10-01T21:13:41Z

[Term]
id: GO:1901436
name: positive regulation of toluene catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of toluene catabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of toluene breakdown" EXACT [GOC:TermGenie]
synonym: "activation of toluene catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of toluene catabolism" EXACT [GOC:TermGenie]
synonym: "activation of toluene degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of toluene breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of toluene catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of toluene degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of toluene breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of toluene catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of toluene catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of toluene degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of toluene breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of toluene catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of toluene catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of toluene degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of toluene breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of toluene catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of toluene catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of toluene degradation" EXACT [GOC:TermGenie]
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1901434 ! regulation of toluene catabolic process
is_a: GO:1901439 ! positive regulation of toluene metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042203 ! toluene catabolic process
relationship: positively_regulates GO:0042203 ! toluene catabolic process
created_by: tt
creation_date: 2012-10-01T21:13:57Z

[Term]
id: GO:1901437
name: regulation of toluene metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of toluene metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of methylbenzene metabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of methylbenzene metabolism" EXACT [GOC:TermGenie]
synonym: "regulation of toluene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0031323 ! regulation of cellular metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0018970 ! toluene metabolic process
relationship: regulates GO:0018970 ! toluene metabolic process
created_by: tt
creation_date: 2012-10-01T21:17:41Z

[Term]
id: GO:1901438
name: negative regulation of toluene metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of toluene metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of methylbenzene metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of methylbenzene metabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of toluene metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of toluene metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of methylbenzene metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of methylbenzene metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of toluene metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of toluene metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of methylbenzene metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of methylbenzene metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of toluene metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of toluene metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of methylbenzene metabolic process" EXACT [GOC:TermGenie]
synonym: "inhibition of methylbenzene metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of toluene metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of toluene metabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of methylbenzene metabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of methylbenzene metabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of toluene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:1901437 ! regulation of toluene metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0018970 ! toluene metabolic process
relationship: negatively_regulates GO:0018970 ! toluene metabolic process
created_by: tt
creation_date: 2012-10-01T21:18:50Z

[Term]
id: GO:1901439
name: positive regulation of toluene metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of toluene metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of methylbenzene metabolic process" EXACT [GOC:TermGenie]
synonym: "activation of methylbenzene metabolism" EXACT [GOC:TermGenie]
synonym: "activation of toluene metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of toluene metabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of methylbenzene metabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of methylbenzene metabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of toluene metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of methylbenzene metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of methylbenzene metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of toluene metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of toluene metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of methylbenzene metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of methylbenzene metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of toluene metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of toluene metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of methylbenzene metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of methylbenzene metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of toluene metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of toluene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:1901437 ! regulation of toluene metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0018970 ! toluene metabolic process
relationship: positively_regulates GO:0018970 ! toluene metabolic process
created_by: tt
creation_date: 2012-10-01T21:19:08Z

[Term]
id: GO:1901440
name: poly(hydroxyalkanoate) metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving poly(hydroxyalkanoate)." [GOC:mengo_curators, GOC:TermGenie]
synonym: "poly(hydroxyalkanoate) metabolism" EXACT [GOC:TermGenie]
is_a: GO:0071704 ! organic substance metabolic process
created_by: tt
creation_date: 2012-10-02T01:47:26Z

[Term]
id: GO:1901441
name: poly(hydroxyalkanoate) biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of poly(hydroxyalkanoate)." [GOC:mengo_curators, GOC:TermGenie]
synonym: "poly(hydroxyalkanoate) anabolism" EXACT [GOC:TermGenie]
synonym: "poly(hydroxyalkanoate) biosynthesis" EXACT [GOC:TermGenie]
synonym: "poly(hydroxyalkanoate) formation" EXACT [GOC:TermGenie]
synonym: "poly(hydroxyalkanoate) synthesis" EXACT [GOC:TermGenie]
is_a: GO:1901440 ! poly(hydroxyalkanoate) metabolic process
is_a: GO:1901576 ! organic substance biosynthetic process
created_by: tt
creation_date: 2012-10-02T01:48:33Z

[Term]
id: GO:1901442
name: regulation of response to furfural
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to furfural." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0048583 ! regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1901426 ! response to furfural
relationship: regulates GO:1901426 ! response to furfural
created_by: tt
creation_date: 2012-10-02T14:09:26Z

[Term]
id: GO:1901443
name: negative regulation of response to furfural
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to furfural." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of response to furfural" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to furfural" EXACT [GOC:TermGenie]
synonym: "downregulation of response to furfural" EXACT [GOC:TermGenie]
synonym: "inhibition of response to furfural" NARROW [GOC:TermGenie]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1901442 ! regulation of response to furfural
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1901426 ! response to furfural
relationship: negatively_regulates GO:1901426 ! response to furfural
created_by: tt
creation_date: 2012-10-02T14:10:34Z

[Term]
id: GO:1901444
name: positive regulation of response to furfural
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to furfural." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of response to furfural" NARROW [GOC:TermGenie]
synonym: "up regulation of response to furfural" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to furfural" EXACT [GOC:TermGenie]
synonym: "upregulation of response to furfural" EXACT [GOC:TermGenie]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1901442 ! regulation of response to furfural
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1901426 ! response to furfural
relationship: positively_regulates GO:1901426 ! response to furfural
created_by: tt
creation_date: 2012-10-02T14:10:51Z

[Term]
id: GO:1901445
name: regulation of response to propan-1-ol
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to propan-1-ol." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:1901419 ! regulation of response to alcohol
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1901427 ! response to propan-1-ol
relationship: regulates GO:1901427 ! response to propan-1-ol
created_by: tt
creation_date: 2012-10-02T14:12:46Z

[Term]
id: GO:1901446
name: negative regulation of response to propan-1-ol
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to propan-1-ol." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of response to propan-1-ol" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to propan-1-ol" EXACT [GOC:TermGenie]
synonym: "downregulation of response to propan-1-ol" EXACT [GOC:TermGenie]
synonym: "inhibition of response to propan-1-ol" NARROW [GOC:TermGenie]
is_a: GO:1901420 ! negative regulation of response to alcohol
is_a: GO:1901445 ! regulation of response to propan-1-ol
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1901427 ! response to propan-1-ol
relationship: negatively_regulates GO:1901427 ! response to propan-1-ol
created_by: tt
creation_date: 2012-10-02T14:13:52Z

[Term]
id: GO:1901447
name: positive regulation of response to propan-1-ol
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to propan-1-ol." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of response to propan-1-ol" NARROW [GOC:TermGenie]
synonym: "up regulation of response to propan-1-ol" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to propan-1-ol" EXACT [GOC:TermGenie]
synonym: "upregulation of response to propan-1-ol" EXACT [GOC:TermGenie]
is_a: GO:1901421 ! positive regulation of response to alcohol
is_a: GO:1901445 ! regulation of response to propan-1-ol
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1901427 ! response to propan-1-ol
relationship: positively_regulates GO:1901427 ! response to propan-1-ol
created_by: tt
creation_date: 2012-10-02T14:14:10Z

[Term]
id: GO:1901448
name: regulation of response to butan-1-ol
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to butan-1-ol." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:1901419 ! regulation of response to alcohol
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1901422 ! response to butan-1-ol
relationship: regulates GO:1901422 ! response to butan-1-ol
created_by: tt
creation_date: 2012-10-02T14:15:50Z

[Term]
id: GO:1901449
name: negative regulation of response to butan-1-ol
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to butan-1-ol." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of response to butan-1-ol" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to butan-1-ol" EXACT [GOC:TermGenie]
synonym: "downregulation of response to butan-1-ol" EXACT [GOC:TermGenie]
synonym: "inhibition of response to butan-1-ol" NARROW [GOC:TermGenie]
is_a: GO:1901420 ! negative regulation of response to alcohol
is_a: GO:1901448 ! regulation of response to butan-1-ol
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1901422 ! response to butan-1-ol
relationship: negatively_regulates GO:1901422 ! response to butan-1-ol
created_by: tt
creation_date: 2012-10-02T14:16:59Z

[Term]
id: GO:1901450
name: positive regulation of response to butan-1-ol
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to butan-1-ol." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of response to butan-1-ol" NARROW [GOC:TermGenie]
synonym: "up regulation of response to butan-1-ol" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to butan-1-ol" EXACT [GOC:TermGenie]
synonym: "upregulation of response to butan-1-ol" EXACT [GOC:TermGenie]
is_a: GO:1901421 ! positive regulation of response to alcohol
is_a: GO:1901448 ! regulation of response to butan-1-ol
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1901422 ! response to butan-1-ol
relationship: positively_regulates GO:1901422 ! response to butan-1-ol
created_by: tt
creation_date: 2012-10-02T14:17:17Z

[Term]
id: GO:1901451
name: regulation of response to benzene
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to benzene." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0048583 ! regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1901423 ! response to benzene
relationship: regulates GO:1901423 ! response to benzene
created_by: tt
creation_date: 2012-10-02T14:19:10Z

[Term]
id: GO:1901452
name: negative regulation of response to benzene
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to benzene." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of response to benzene" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to benzene" EXACT [GOC:TermGenie]
synonym: "downregulation of response to benzene" EXACT [GOC:TermGenie]
synonym: "inhibition of response to benzene" NARROW [GOC:TermGenie]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1901451 ! regulation of response to benzene
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1901423 ! response to benzene
relationship: negatively_regulates GO:1901423 ! response to benzene
created_by: tt
creation_date: 2012-10-02T14:20:23Z

[Term]
id: GO:1901453
name: positive regulation of response to benzene
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to benzene." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of response to benzene" NARROW [GOC:TermGenie]
synonym: "up regulation of response to benzene" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to benzene" EXACT [GOC:TermGenie]
synonym: "upregulation of response to benzene" EXACT [GOC:TermGenie]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1901451 ! regulation of response to benzene
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1901423 ! response to benzene
relationship: positively_regulates GO:1901423 ! response to benzene
created_by: tt
creation_date: 2012-10-02T14:20:41Z

[Term]
id: GO:1901454
name: regulation of response to toluene
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to toluene." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0048583 ! regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1901424 ! response to toluene
relationship: regulates GO:1901424 ! response to toluene
created_by: tt
creation_date: 2012-10-02T14:22:17Z

[Term]
id: GO:1901455
name: negative regulation of response to toluene
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to toluene." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of response to toluene" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to toluene" EXACT [GOC:TermGenie]
synonym: "downregulation of response to toluene" EXACT [GOC:TermGenie]
synonym: "inhibition of response to toluene" NARROW [GOC:TermGenie]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1901454 ! regulation of response to toluene
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1901424 ! response to toluene
relationship: negatively_regulates GO:1901424 ! response to toluene
created_by: tt
creation_date: 2012-10-02T14:23:28Z

[Term]
id: GO:1901456
name: positive regulation of response to toluene
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to toluene." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of response to toluene" NARROW [GOC:TermGenie]
synonym: "up regulation of response to toluene" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to toluene" EXACT [GOC:TermGenie]
synonym: "upregulation of response to toluene" EXACT [GOC:TermGenie]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1901454 ! regulation of response to toluene
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1901424 ! response to toluene
relationship: positively_regulates GO:1901424 ! response to toluene
created_by: tt
creation_date: 2012-10-02T14:23:45Z

[Term]
id: GO:1901457
name: regulation of response to acetate
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to acetate." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0048583 ! regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010034 ! response to acetate
relationship: regulates GO:0010034 ! response to acetate
created_by: tt
creation_date: 2012-10-02T14:25:06Z

[Term]
id: GO:1901458
name: negative regulation of response to acetate
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to acetate." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of response to acetate" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to acetate" EXACT [GOC:TermGenie]
synonym: "downregulation of response to acetate" EXACT [GOC:TermGenie]
synonym: "inhibition of response to acetate" NARROW [GOC:TermGenie]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1901457 ! regulation of response to acetate
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010034 ! response to acetate
relationship: negatively_regulates GO:0010034 ! response to acetate
created_by: tt
creation_date: 2012-10-02T14:26:15Z

[Term]
id: GO:1901459
name: positive regulation of response to acetate
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to acetate." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of response to acetate" NARROW [GOC:TermGenie]
synonym: "up regulation of response to acetate" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to acetate" EXACT [GOC:TermGenie]
synonym: "upregulation of response to acetate" EXACT [GOC:TermGenie]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1901457 ! regulation of response to acetate
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010034 ! response to acetate
relationship: positively_regulates GO:0010034 ! response to acetate
created_by: tt
creation_date: 2012-10-02T14:26:34Z

[Term]
id: GO:1901460
name: regulation of response to formic acid
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to formic acid." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0048583 ! regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1901425 ! response to formic acid
relationship: regulates GO:1901425 ! response to formic acid
created_by: tt
creation_date: 2012-10-02T14:27:54Z

[Term]
id: GO:1901461
name: negative regulation of response to formic acid
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to formic acid." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of response to formic acid" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to formic acid" EXACT [GOC:TermGenie]
synonym: "downregulation of response to formic acid" EXACT [GOC:TermGenie]
synonym: "inhibition of response to formic acid" NARROW [GOC:TermGenie]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1901460 ! regulation of response to formic acid
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1901425 ! response to formic acid
relationship: negatively_regulates GO:1901425 ! response to formic acid
created_by: tt
creation_date: 2012-10-02T14:29:02Z

[Term]
id: GO:1901462
name: positive regulation of response to formic acid
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to formic acid." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of response to formic acid" NARROW [GOC:TermGenie]
synonym: "up regulation of response to formic acid" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to formic acid" EXACT [GOC:TermGenie]
synonym: "upregulation of response to formic acid" EXACT [GOC:TermGenie]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1901460 ! regulation of response to formic acid
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1901425 ! response to formic acid
relationship: positively_regulates GO:1901425 ! response to formic acid
created_by: tt
creation_date: 2012-10-02T14:29:20Z

[Term]
id: GO:1901463
name: regulation of tetrapyrrole biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tetrapyrrole biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of tetrapyrrole formation" EXACT [GOC:TermGenie]
synonym: "regulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:1901401 ! regulation of tetrapyrrole metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0033014 ! tetrapyrrole biosynthetic process
relationship: regulates GO:0033014 ! tetrapyrrole biosynthetic process
created_by: tt
creation_date: 2012-10-02T14:34:14Z

[Term]
id: GO:1901464
name: negative regulation of tetrapyrrole biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of tetrapyrrole biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of tetrapyrrole formation" EXACT [GOC:TermGenie]
synonym: "down regulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetrapyrrole biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetrapyrrole formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of tetrapyrrole biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of tetrapyrrole formation" EXACT [GOC:TermGenie]
synonym: "downregulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of tetrapyrrole anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of tetrapyrrole biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of tetrapyrrole formation" EXACT [GOC:TermGenie]
synonym: "inhibition of tetrapyrrole synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of tetrapyrrole formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:1901402 ! negative regulation of tetrapyrrole metabolic process
is_a: GO:1901463 ! regulation of tetrapyrrole biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0033014 ! tetrapyrrole biosynthetic process
relationship: negatively_regulates GO:0033014 ! tetrapyrrole biosynthetic process
created_by: tt
creation_date: 2012-10-02T14:35:26Z

[Term]
id: GO:1901465
name: positive regulation of tetrapyrrole biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tetrapyrrole biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of tetrapyrrole anabolism" EXACT [GOC:TermGenie]
synonym: "activation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of tetrapyrrole biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of tetrapyrrole formation" EXACT [GOC:TermGenie]
synonym: "activation of tetrapyrrole synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of tetrapyrrole formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of tetrapyrrole biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of tetrapyrrole formation" EXACT [GOC:TermGenie]
synonym: "up regulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetrapyrrole biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetrapyrrole formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of tetrapyrrole biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of tetrapyrrole formation" EXACT [GOC:TermGenie]
synonym: "upregulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:1901403 ! positive regulation of tetrapyrrole metabolic process
is_a: GO:1901463 ! regulation of tetrapyrrole biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0033014 ! tetrapyrrole biosynthetic process
relationship: positively_regulates GO:0033014 ! tetrapyrrole biosynthetic process
created_by: tt
creation_date: 2012-10-02T14:35:43Z

[Term]
id: GO:1901466
name: regulation of ferulate catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ferulate catabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of ferulate breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of ferulate catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of ferulate degradation" EXACT [GOC:TermGenie]
is_a: GO:0010565 ! regulation of cellular ketone metabolic process
is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:2000762 ! regulation of phenylpropanoid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1901067 ! ferulate catabolic process
relationship: regulates GO:1901067 ! ferulate catabolic process
created_by: tt
creation_date: 2012-10-02T14:37:29Z

[Term]
id: GO:1901467
name: negative regulation of ferulate catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ferulate catabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of ferulate breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of ferulate catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of ferulate catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of ferulate degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of ferulate breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of ferulate catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of ferulate catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of ferulate degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of ferulate breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of ferulate catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of ferulate catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of ferulate degradation" EXACT [GOC:TermGenie]
synonym: "inhibition of ferulate breakdown" EXACT [GOC:TermGenie]
synonym: "inhibition of ferulate catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of ferulate catabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of ferulate degradation" EXACT [GOC:TermGenie]
synonym: "negative regulation of ferulate breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of ferulate catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of ferulate degradation" EXACT [GOC:TermGenie]
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:1901466 ! regulation of ferulate catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1901067 ! ferulate catabolic process
relationship: negatively_regulates GO:1901067 ! ferulate catabolic process
created_by: tt
creation_date: 2012-10-02T14:38:38Z

[Term]
id: GO:1901468
name: positive regulation of ferulate catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ferulate catabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of ferulate breakdown" EXACT [GOC:TermGenie]
synonym: "activation of ferulate catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of ferulate catabolism" EXACT [GOC:TermGenie]
synonym: "activation of ferulate degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of ferulate breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of ferulate catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of ferulate degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of ferulate breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of ferulate catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of ferulate catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of ferulate degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of ferulate breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of ferulate catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of ferulate catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of ferulate degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of ferulate breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of ferulate catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of ferulate catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of ferulate degradation" EXACT [GOC:TermGenie]
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:1901466 ! regulation of ferulate catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1901067 ! ferulate catabolic process
relationship: positively_regulates GO:1901067 ! ferulate catabolic process
created_by: tt
creation_date: 2012-10-02T14:38:56Z

[Term]
id: GO:1901469
name: regulation of syringal lignin catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of syringal lignin catabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of S-lignin catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of syringal lignin breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of syringal lignin catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of syringal lignin degradation" EXACT [GOC:TermGenie]
is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:2000762 ! regulation of phenylpropanoid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1901065 ! syringal lignin catabolic process
relationship: regulates GO:1901065 ! syringal lignin catabolic process
created_by: tt
creation_date: 2012-10-02T14:41:12Z

[Term]
id: GO:1901470
name: negative regulation of syringal lignin catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of syringal lignin catabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of S-lignin catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of syringal lignin breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of syringal lignin catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of syringal lignin catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of syringal lignin degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of S-lignin catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of syringal lignin breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of syringal lignin catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of syringal lignin catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of syringal lignin degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of S-lignin catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of syringal lignin breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of syringal lignin catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of syringal lignin catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of syringal lignin degradation" EXACT [GOC:TermGenie]
synonym: "inhibition of S-lignin catabolic process" EXACT [GOC:TermGenie]
synonym: "inhibition of syringal lignin breakdown" EXACT [GOC:TermGenie]
synonym: "inhibition of syringal lignin catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of syringal lignin catabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of syringal lignin degradation" EXACT [GOC:TermGenie]
synonym: "negative regulation of S-lignin catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of syringal lignin breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of syringal lignin catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of syringal lignin degradation" EXACT [GOC:TermGenie]
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:1901469 ! regulation of syringal lignin catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1901065 ! syringal lignin catabolic process
relationship: negatively_regulates GO:1901065 ! syringal lignin catabolic process
created_by: tt
creation_date: 2012-10-02T14:42:21Z

[Term]
id: GO:1901471
name: positive regulation of syringal lignin catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of syringal lignin catabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of S-lignin catabolic process" EXACT [GOC:TermGenie]
synonym: "activation of syringal lignin breakdown" EXACT [GOC:TermGenie]
synonym: "activation of syringal lignin catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of syringal lignin catabolism" EXACT [GOC:TermGenie]
synonym: "activation of syringal lignin degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of S-lignin catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of syringal lignin breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of syringal lignin catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of syringal lignin degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of S-lignin catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of syringal lignin breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of syringal lignin catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of syringal lignin catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of syringal lignin degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of S-lignin catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of syringal lignin breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of syringal lignin catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of syringal lignin catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of syringal lignin degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of S-lignin catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of syringal lignin breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of syringal lignin catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of syringal lignin catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of syringal lignin degradation" EXACT [GOC:TermGenie]
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:1901469 ! regulation of syringal lignin catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1901065 ! syringal lignin catabolic process
relationship: positively_regulates GO:1901065 ! syringal lignin catabolic process
created_by: tt
creation_date: 2012-10-02T14:42:39Z

[Term]
id: GO:1901472
name: regulation of Golgi calcium ion export
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Golgi calcium ion export." [GOC:TermGenie]
is_a: GO:0051279 ! regulation of release of sequestered calcium ion into cytosol
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061454 ! Golgi calcium ion export
relationship: regulates GO:0061454 ! Golgi calcium ion export
created_by: al
creation_date: 2012-10-03T07:26:03Z

[Term]
id: GO:1901474
name: azole transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of azole from one side of the membrane to the other." [GOC:TermGenie]
is_a: GO:0015238 ! drug transmembrane transporter activity
is_a: GO:0045118 ! azole transporter activity
created_by: tb
creation_date: 2012-10-04T20:00:27Z

[Term]
id: GO:1901475
name: pyruvate transmembrane transport
namespace: biological_process
def: "The directed movement of pyruvate across a membrane." [GOC:TermGenie]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "pyruvate membrane transport" EXACT []
is_a: GO:0006848 ! pyruvate transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport
created_by: tb
creation_date: 2012-10-04T20:52:54Z

[Term]
id: GO:1901476
name: carbohydrate transporter activity
namespace: molecular_function
def: "Enables the directed movement of carbohydrate into, out of or within a cell, or between cells." [GOC:TermGenie]
is_a: GO:0005215 ! transporter activity
relationship: part_of GO:0008643 ! carbohydrate transport
created_by: tb
creation_date: 2012-10-04T21:00:18Z

[Term]
id: GO:1901477
name: benomyl transmembrane transport
namespace: biological_process
def: "The directed movement of benomyl across a membrane." [GOC:TermGenie]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "benomyl membrane transport" EXACT []
is_a: GO:0006855 ! drug transmembrane transport
is_a: GO:0015900 ! benomyl transport
created_by: tb
creation_date: 2012-10-04T23:11:36Z

[Term]
id: GO:1901478
name: aminotriazole transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of amitrole from one side of the membrane to the other." [GOC:TermGenie]
is_a: GO:0005275 ! amine transmembrane transporter activity
is_a: GO:0015241 ! aminotriazole transporter activity
is_a: GO:1901474 ! azole transmembrane transporter activity
created_by: tb
creation_date: 2012-10-04T23:21:06Z

[Term]
id: GO:1901479
name: benomyl transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of benomyl from one side of the membrane to the other." [GOC:TermGenie]
is_a: GO:0015238 ! drug transmembrane transporter activity
is_a: GO:0015242 ! benomyl transporter activity
is_a: GO:0042887 ! amide transmembrane transporter activity
relationship: part_of GO:1901477 ! benomyl transmembrane transport
created_by: tb
creation_date: 2012-10-04T23:21:10Z

[Term]
id: GO:1901480
name: oleate transporter activity
namespace: molecular_function
def: "Enables the directed movement of oleate into, out of or within a cell, or between cells." [GOC:TermGenie, RHEA:33658]
is_a: GO:0005324 ! long-chain fatty acid transporter activity
created_by: ab
creation_date: 2012-10-07T17:11:56Z

[Term]
id: GO:1901481
name: L-glutamate import involved in cellular response to nitrogen starvation
namespace: biological_process
def: "Any L-glutamate import that is involved in cellular response to nitrogen starvation." [GOC:TermGenie]
synonym: "L-glutamate uptake involved in cellular response to nitrogen starvation" EXACT [GOC:TermGenie]
is_a: GO:0051938 ! L-glutamate import
intersection_of: GO:0051938 ! L-glutamate import
intersection_of: part_of GO:0006995 ! cellular response to nitrogen starvation
relationship: part_of GO:0006995 ! cellular response to nitrogen starvation
created_by: al
creation_date: 2012-10-08T08:32:29Z

[Term]
id: GO:1901482
name: L-lysine import involved in cellular response to nitrogen starvation
namespace: biological_process
def: "Any L-lysine import that is involved in cellular response to nitrogen starvation." [GOC:TermGenie]
is_a: GO:0061461 ! L-lysine import
intersection_of: GO:0061461 ! L-lysine import
intersection_of: part_of GO:0006995 ! cellular response to nitrogen starvation
relationship: part_of GO:0006995 ! cellular response to nitrogen starvation
created_by: al
creation_date: 2012-10-08T08:34:03Z

[Term]
id: GO:1901483
name: regulation of transcription factor catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription factor catabolic process." [GOC:al, GOC:TermGenie, GOC:vw, PMID:22833559]
synonym: "regulation of proteasome-mediated transcription factor catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of sequence-specific DNA binding transcription factor catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of transcription factor breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of transcription factor catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of transcription factor degradation" EXACT [GOC:TermGenie]
is_a: GO:0032434 ! regulation of proteasomal ubiquitin-dependent protein catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0036369 ! transcription factor catabolic process
relationship: regulates GO:0036369 ! transcription factor catabolic process
created_by: bf
creation_date: 2012-10-08T09:03:18Z

[Term]
id: GO:1901484
name: negative regulation of transcription factor catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription factor catabolic process." [GOC:al, GOC:TermGenie, GOC:vw]
synonym: "down regulation of proteasome-mediated transcription factor catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of sequence-specific DNA binding transcription factor catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of transcription factor breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of transcription factor catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of transcription factor catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of transcription factor degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of proteasome-mediated transcription factor catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of sequence-specific DNA binding transcription factor catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of transcription factor breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of transcription factor catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of transcription factor catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of transcription factor degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of proteasome-mediated transcription factor catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of sequence-specific DNA binding transcription factor catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of transcription factor breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of transcription factor catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of transcription factor catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of transcription factor degradation" EXACT [GOC:TermGenie]
synonym: "inhibition of proteasome-mediated transcription factor catabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of sequence-specific DNA binding transcription factor catabolic process" EXACT [GOC:TermGenie]
synonym: "inhibition of transcription factor breakdown" EXACT [GOC:TermGenie]
synonym: "inhibition of transcription factor catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of transcription factor catabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of transcription factor degradation" EXACT [GOC:TermGenie]
synonym: "negative regulation of proteasome-mediated transcription factor catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of sequence-specific DNA binding transcription factor catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of transcription factor breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of transcription factor catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of transcription factor degradation" EXACT [GOC:TermGenie]
is_a: GO:0032435 ! negative regulation of proteasomal ubiquitin-dependent protein catabolic process
is_a: GO:1901483 ! regulation of transcription factor catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0036369 ! transcription factor catabolic process
relationship: negatively_regulates GO:0036369 ! transcription factor catabolic process
created_by: bf
creation_date: 2012-10-08T09:03:22Z

[Term]
id: GO:1901485
name: positive regulation of transcription factor catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transcription factor catabolic process." [GOC:al, GOC:TermGenie, GOC:vw, PMID:22833559]
synonym: "activation of proteasome-mediated transcription factor catabolism" EXACT [GOC:TermGenie]
synonym: "activation of sequence-specific DNA binding transcription factor catabolic process" EXACT [GOC:TermGenie]
synonym: "activation of transcription factor breakdown" EXACT [GOC:TermGenie]
synonym: "activation of transcription factor catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of transcription factor catabolism" EXACT [GOC:TermGenie]
synonym: "activation of transcription factor degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of proteasome-mediated transcription factor catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of sequence-specific DNA binding transcription factor catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription factor breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription factor catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription factor degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of proteasome-mediated transcription factor catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of sequence-specific DNA binding transcription factor catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of transcription factor breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of transcription factor catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of transcription factor catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of transcription factor degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of proteasome-mediated transcription factor catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of sequence-specific DNA binding transcription factor catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of transcription factor breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of transcription factor catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of transcription factor catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of transcription factor degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of proteasome-mediated transcription factor catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of sequence-specific DNA binding transcription factor catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of transcription factor breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of transcription factor catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of transcription factor catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of transcription factor degradation" EXACT [GOC:TermGenie]
is_a: GO:0032436 ! positive regulation of proteasomal ubiquitin-dependent protein catabolic process
is_a: GO:1901483 ! regulation of transcription factor catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0036369 ! transcription factor catabolic process
relationship: positively_regulates GO:0036369 ! transcription factor catabolic process
created_by: bf
creation_date: 2012-10-08T09:03:27Z

[Term]
id: GO:1901486
name: negative regulation of SREBP signaling pathway by positive regulation of transcription factor catabolic process
namespace: biological_process
def: "Positive regulation of transcription factor catabolism that results in negative regulation of the SREBP signaling pathway." [GOC:TermGenie, GOC:vw, PMID:22833559]
synonym: "negative regulation of SREBP signaling pathway by positive regulation of SREBP degradation" NARROW [GOC:bf]
synonym: "negative regulation of SREBP signaling pathway by positive regulation of transcription factor catabolism" EXACT [GOC:bf]
synonym: "negative regulation of SREBP-mediated signaling pathway by positive regulation of transcription factor catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of SREBP-mediated signalling pathway by positive regulation of transcription factor catabolic process" EXACT [GOC:TermGenie]
is_a: GO:1901485 ! positive regulation of transcription factor catabolic process
is_a: GO:2000639 ! negative regulation of SREBP signaling pathway
intersection_of: GO:1901485 ! positive regulation of transcription factor catabolic process
intersection_of: negatively_regulates GO:0032933 ! SREBP signaling pathway
relationship: negatively_regulates GO:0032933 ! SREBP signaling pathway
created_by: bf
creation_date: 2012-10-09T08:23:26Z

[Term]
id: GO:1901487
name: negative regulation of SREBP signaling pathway by positive regulation of transcription factor catabolic process in response to increased oxygen levels
namespace: biological_process
def: "Positive regulation of transcription factor catabolism in response to increased oxygen levels, which results in negative regulation of the SREBP signaling pathway." [GOC:TermGenie, GOC:vw, PMID:22833559]
synonym: "negative regulation of SREBP signaling by acceleration of SREBP degradation, in response to increased oxygen levels" NARROW [PMID:22833559]
synonym: "negative regulation of SREBP signaling by positive regulation of transcription factor catabolism in response to increased oxygen levels" EXACT [GOC:bf]
synonym: "negative regulation of SREBP signaling pathway by positive regulation of SREBP degradation, in response to elevated oxygen" NARROW [GOC:bf]
synonym: "negative regulation of SREBP-mediated signaling pathway in presence of oxygen by positive regulation of transcription factor catabolic process" RELATED [GOC:TermGenie]
synonym: "negative regulation of SREBP-mediated signaling pathway in response to increased oxygen levels by positive regulation of transcription factor catabolic process" EXACT [GOC:TermGenie]
is_a: GO:0038175 ! negative regulation of SREBP signaling pathway in response to increased oxygen levels
is_a: GO:1901486 ! negative regulation of SREBP signaling pathway by positive regulation of transcription factor catabolic process
created_by: bf
creation_date: 2012-10-09T08:23:33Z

[Term]
id: GO:1901488
name: positive regulation of SREBP signaling pathway by negative regulation of transcription factor catabolic process
namespace: biological_process
def: "Negative regulation of transcription factor catabolism that results in positive regulation of the SREBP signaling pathway." [GOC:TermGenie, GOC:vw, PMID:22833559]
synonym: "positive regulation of SREBP signaling pathway by inhibition of SREBP degradation" NARROW [PMID:22833559]
synonym: "positive regulation of SREBP signaling pathway by negative regulation of SREBP degradation" NARROW [PMID:22833559]
synonym: "positive regulation of SREBP signaling pathway by negative regulation of transcription factor catabolism" EXACT [GOC:bf]
synonym: "positive regulation of SREBP-mediated signaling pathway by negative regulation of transcription factor catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of SREBP-mediated signalling pathway by negative regulation of transcription factor catabolic process" EXACT [GOC:TermGenie]
is_a: GO:1901484 ! negative regulation of transcription factor catabolic process
is_a: GO:2000640 ! positive regulation of SREBP signaling pathway
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: negatively_regulates GO:0100062 ! positive regulation of SREBP signaling pathway by transcription factor catabolic process
relationship: negatively_regulates GO:0100062 ! positive regulation of SREBP signaling pathway by transcription factor catabolic process
created_by: bf
creation_date: 2012-10-09T08:23:43Z

[Term]
id: GO:1901489
name: positive regulation of SREBP signaling pathway by negative regulation of transcription factor catabolic process in response to decreased oxygen levels
namespace: biological_process
def: "Negative regulation of transcription factor catabolism in response to decreased oxygen levels, which results in positive regulation of the SREBP signaling pathway." [GOC:TermGenie, GOC:vw, PMID:22833559]
synonym: "positive regulation of SREBP signaling by inhibition of SREBP degradation in response to decreased oxygen levels" EXACT [GOC:bf]
synonym: "positive regulation of SREBP signaling by negative regulation of transcription factor catabolism at low oxygen levels" EXACT [GOC:bf]
synonym: "positive regulation of SREBP signaling pathway by negative regulation of SREBP degradation, in response to decreased oxygen" NARROW [PMID:22833559]
synonym: "positive regulation of SREBP-mediated signaling pathway in absence of oxygen by negative regulation of transcription factor catabolic process" RELATED [GOC:TermGenie]
synonym: "positive regulation of SREBP-mediated signaling pathway in response to decreased oxygen levels by negative regulation of transcription factor catabolic process" EXACT [GOC:TermGenie]
is_a: GO:0038176 ! positive regulation of SREBP signaling pathway in response to decreased oxygen levels
is_a: GO:1901488 ! positive regulation of SREBP signaling pathway by negative regulation of transcription factor catabolic process
created_by: bf
creation_date: 2012-10-09T08:23:50Z

[Term]
id: GO:1901490
name: regulation of lymphangiogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lymphangiogenesis." [GOC:dph, GOC:TermGenie, PMID:20133819]
synonym: "regulation of lymph vessel formation" EXACT [GOC:TermGenie]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:1901342 ! regulation of vasculature development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001946 ! lymphangiogenesis
relationship: regulates GO:0001946 ! lymphangiogenesis
created_by: dph
creation_date: 2012-10-15T13:08:17Z

[Term]
id: GO:1901491
name: negative regulation of lymphangiogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lymphangiogenesis." [GOC:dph, GOC:TermGenie, PMID:20133819]
synonym: "down regulation of lymph vessel formation" EXACT [GOC:TermGenie]
synonym: "down regulation of lymphangiogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of lymph vessel formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of lymphangiogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of lymph vessel formation" EXACT [GOC:TermGenie]
synonym: "downregulation of lymphangiogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of lymph vessel formation" NARROW [GOC:TermGenie]
synonym: "inhibition of lymphangiogenesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of lymph vessel formation" EXACT [GOC:TermGenie]
is_a: GO:1901343 ! negative regulation of vasculature development
is_a: GO:1901490 ! regulation of lymphangiogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001946 ! lymphangiogenesis
relationship: negatively_regulates GO:0001946 ! lymphangiogenesis
created_by: dph
creation_date: 2012-10-15T13:08:21Z

[Term]
id: GO:1901492
name: positive regulation of lymphangiogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lymphangiogenesis." [GOC:dph, GOC:TermGenie, PMID:20133819]
synonym: "activation of lymph vessel formation" NARROW [GOC:TermGenie]
synonym: "activation of lymphangiogenesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of lymph vessel formation" EXACT [GOC:TermGenie]
synonym: "up regulation of lymph vessel formation" EXACT [GOC:TermGenie]
synonym: "up regulation of lymphangiogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of lymph vessel formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of lymphangiogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of lymph vessel formation" EXACT [GOC:TermGenie]
synonym: "upregulation of lymphangiogenesis" EXACT [GOC:TermGenie]
is_a: GO:1901490 ! regulation of lymphangiogenesis
is_a: GO:1904018 ! positive regulation of vasculature development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001946 ! lymphangiogenesis
relationship: positively_regulates GO:0001946 ! lymphangiogenesis
created_by: dph
creation_date: 2012-10-15T13:08:25Z

[Term]
id: GO:1901493
name: response to decalin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a decalin stimulus." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0014070 ! response to organic cyclic compound
created_by: tt
creation_date: 2012-10-16T13:41:09Z

[Term]
id: GO:1901494
name: regulation of cysteine metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cysteine metabolic process." [GOC:TermGenie]
synonym: "regulation of cysteine metabolism" EXACT [GOC:TermGenie]
is_a: GO:0031335 ! regulation of sulfur amino acid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006534 ! cysteine metabolic process
relationship: regulates GO:0006534 ! cysteine metabolic process
created_by: vw
creation_date: 2012-10-16T14:28:42Z

[Term]
id: GO:1901495
name: negative regulation of cysteine metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cysteine metabolic process." [GOC:TermGenie]
synonym: "down regulation of cysteine metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of cysteine metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of cysteine metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of cysteine metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of cysteine metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of cysteine metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of cysteine metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of cysteine metabolism" NARROW [GOC:TermGenie]
synonym: "negative regulation of cysteine metabolism" EXACT [GOC:TermGenie]
is_a: GO:0031336 ! negative regulation of sulfur amino acid metabolic process
is_a: GO:1901494 ! regulation of cysteine metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006534 ! cysteine metabolic process
relationship: negatively_regulates GO:0006534 ! cysteine metabolic process
created_by: vw
creation_date: 2012-10-16T14:28:47Z

[Term]
id: GO:1901496
name: positive regulation of cysteine metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cysteine metabolic process." [GOC:TermGenie]
synonym: "activation of cysteine metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of cysteine metabolism" NARROW [GOC:TermGenie]
synonym: "positive regulation of cysteine metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of cysteine metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of cysteine metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of cysteine metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of cysteine metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of cysteine metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of cysteine metabolism" EXACT [GOC:TermGenie]
is_a: GO:0031337 ! positive regulation of sulfur amino acid metabolic process
is_a: GO:1901494 ! regulation of cysteine metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006534 ! cysteine metabolic process
relationship: positively_regulates GO:0006534 ! cysteine metabolic process
created_by: vw
creation_date: 2012-10-16T14:28:51Z

[Term]
id: GO:1901497
name: response to diphenyl ether
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diphenyl ether stimulus." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0045472 ! response to ether
created_by: tt
creation_date: 2012-10-16T14:58:08Z

[Term]
id: GO:1901498
name: response to tetralin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetralin stimulus." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0014070 ! response to organic cyclic compound
created_by: tt
creation_date: 2012-10-16T15:10:22Z

[Term]
id: GO:1901499
name: response to hexane
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexane stimulus." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:1902778 ! response to alkane
created_by: tt
creation_date: 2012-10-16T15:14:49Z

[Term]
id: GO:1901500
name: response to p-xylene
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a p-xylene stimulus." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:1901501 ! response to xylene
created_by: tt
creation_date: 2012-10-16T15:23:54Z

[Term]
id: GO:1901501
name: response to xylene
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xylene stimulus." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0014070 ! response to organic cyclic compound
created_by: tt
creation_date: 2012-10-16T15:25:47Z

[Term]
id: GO:1901502
name: ether catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ether." [GOC:pr, GOC:TermGenie]
synonym: "ether breakdown" EXACT [GOC:TermGenie]
synonym: "ether catabolism" EXACT [GOC:TermGenie]
synonym: "ether degradation" EXACT [GOC:TermGenie]
is_a: GO:0018904 ! ether metabolic process
is_a: GO:0044712 ! single-organism catabolic process
is_a: GO:1901575 ! organic substance catabolic process
created_by: pr
creation_date: 2012-10-17T09:42:43Z

[Term]
id: GO:1901503
name: ether biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ether." [GOC:pr, GOC:TermGenie]
synonym: "ether anabolism" EXACT [GOC:TermGenie]
synonym: "ether biosynthesis" EXACT [GOC:TermGenie]
synonym: "ether formation" EXACT [GOC:TermGenie]
synonym: "ether synthesis" EXACT [GOC:TermGenie]
is_a: GO:0018904 ! ether metabolic process
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:1901576 ! organic substance biosynthetic process
created_by: pr
creation_date: 2012-10-17T09:42:47Z

[Term]
id: GO:1901504
name: triazole transport
namespace: biological_process
def: "The directed movement of a triazole into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:pr, GOC:TermGenie]
is_a: GO:0045117 ! azole transport
created_by: pr
creation_date: 2012-10-17T09:47:46Z

[Term]
id: GO:1901505
name: carbohydrate derivative transporter activity
namespace: molecular_function
def: "Enables the directed movement of carbohydrate derivative into, out of or within a cell, or between cells." [GOC:pr, GOC:TermGenie]
is_a: GO:0005215 ! transporter activity
relationship: part_of GO:1901264 ! carbohydrate derivative transport
created_by: pr
creation_date: 2012-10-17T10:31:22Z

[Term]
id: GO:1901506
name: regulation of acylglycerol transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of acylglycerol transport." [GOC:sart, GOC:TermGenie]
synonym: "regulation of glyceride transport" EXACT [GOC:TermGenie]
is_a: GO:0032368 ! regulation of lipid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034196 ! acylglycerol transport
relationship: regulates GO:0034196 ! acylglycerol transport
created_by: sart
creation_date: 2012-10-17T11:06:10Z

[Term]
id: GO:1901507
name: negative regulation of acylglycerol transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of acylglycerol transport." [GOC:sart, GOC:TermGenie]
synonym: "down regulation of acylglycerol transport" EXACT [GOC:TermGenie]
synonym: "down regulation of glyceride transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of acylglycerol transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of glyceride transport" EXACT [GOC:TermGenie]
synonym: "downregulation of acylglycerol transport" EXACT [GOC:TermGenie]
synonym: "downregulation of glyceride transport" EXACT [GOC:TermGenie]
synonym: "inhibition of acylglycerol transport" NARROW [GOC:TermGenie]
synonym: "inhibition of glyceride transport" NARROW [GOC:TermGenie]
synonym: "negative regulation of glyceride transport" EXACT [GOC:TermGenie]
is_a: GO:0032369 ! negative regulation of lipid transport
is_a: GO:1901506 ! regulation of acylglycerol transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034196 ! acylglycerol transport
relationship: negatively_regulates GO:0034196 ! acylglycerol transport
created_by: sart
creation_date: 2012-10-17T11:06:18Z

[Term]
id: GO:1901508
name: positive regulation of acylglycerol transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of acylglycerol transport." [GOC:sart, GOC:TermGenie]
synonym: "activation of acylglycerol transport" NARROW [GOC:TermGenie]
synonym: "activation of glyceride transport" NARROW [GOC:TermGenie]
synonym: "positive regulation of glyceride transport" EXACT [GOC:TermGenie]
synonym: "up regulation of acylglycerol transport" EXACT [GOC:TermGenie]
synonym: "up regulation of glyceride transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of acylglycerol transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of glyceride transport" EXACT [GOC:TermGenie]
synonym: "upregulation of acylglycerol transport" EXACT [GOC:TermGenie]
synonym: "upregulation of glyceride transport" EXACT [GOC:TermGenie]
is_a: GO:0032370 ! positive regulation of lipid transport
is_a: GO:1901506 ! regulation of acylglycerol transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034196 ! acylglycerol transport
relationship: positively_regulates GO:0034196 ! acylglycerol transport
created_by: sart
creation_date: 2012-10-17T11:06:23Z

[Term]
id: GO:1901509
name: regulation of endothelial tube morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endothelial tube morphogenesis." [GOC:dph, GOC:TermGenie]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061154 ! endothelial tube morphogenesis
relationship: regulates GO:0061154 ! endothelial tube morphogenesis
created_by: dph
creation_date: 2012-10-17T14:30:40Z

[Term]
id: GO:1901510
name: (-)-microperfuranone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (-)-microperfuranone." [GOC:di, GOC:TermGenie]
synonym: "(-)-microperfuranone metabolism" EXACT [GOC:TermGenie]
is_a: GO:0018904 ! ether metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:1901334 ! lactone metabolic process
created_by: di
creation_date: 2012-10-18T06:54:10Z

[Term]
id: GO:1901511
name: (-)-microperfuranone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of (-)-microperfuranone." [GOC:di, GOC:TermGenie]
synonym: "(-)-microperfuranone breakdown" EXACT [GOC:TermGenie]
synonym: "(-)-microperfuranone catabolism" EXACT [GOC:TermGenie]
synonym: "(-)-microperfuranone degradation" EXACT [GOC:TermGenie]
is_a: GO:1901335 ! lactone catabolic process
is_a: GO:1901502 ! ether catabolic process
is_a: GO:1901510 ! (-)-microperfuranone metabolic process
created_by: di
creation_date: 2012-10-18T06:54:14Z

[Term]
id: GO:1901512
name: (-)-microperfuranone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (-)-microperfuranone." [GOC:di, GOC:TermGenie]
synonym: "(-)-microperfuranone anabolism" EXACT [GOC:TermGenie]
synonym: "(-)-microperfuranone biosynthesis" EXACT [GOC:TermGenie]
synonym: "(-)-microperfuranone formation" EXACT [GOC:TermGenie]
synonym: "(-)-microperfuranone synthesis" EXACT [GOC:TermGenie]
is_a: GO:1901336 ! lactone biosynthetic process
is_a: GO:1901503 ! ether biosynthetic process
is_a: GO:1901510 ! (-)-microperfuranone metabolic process
created_by: di
creation_date: 2012-10-18T06:54:18Z

[Term]
id: GO:1901513
name: lipo-chitin oligosaccharide transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of lipo-chitin oligosaccharide from one side of the membrane to the other." [GOC:TermGenie]
is_a: GO:0022857 ! transmembrane transporter activity
created_by: jl
creation_date: 2012-10-18T11:52:51Z

[Term]
id: GO:1901514
name: lipo-chitin oligosaccharide transmembrane-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + lipo-chitin oligosaccharide(in) = ADP + phosphate + lipo-chitin oligosaccharide(out)." [GOC:TermGenie]
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances
is_a: GO:1901513 ! lipo-chitin oligosaccharide transmembrane transporter activity
created_by: jl
creation_date: 2012-10-18T11:52:55Z

[Term]
id: GO:1901515
name: poly-beta-1,6-N-acetyl-D-glucosamine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of poly-beta-1,6-N-acetyl-D-glucosamine from one side of the membrane to the other." [GOC:TermGenie]
is_a: GO:0022857 ! transmembrane transporter activity
created_by: jl
creation_date: 2012-10-18T11:57:04Z

[Term]
id: GO:1901516
name: aspyridone A metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aspyridone A." [GOC:di, GOC:TermGenie]
synonym: "aspyridone A metabolism" EXACT [GOC:TermGenie]
is_a: GO:0030638 ! polyketide metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0072524 ! pyridine-containing compound metabolic process
created_by: di
creation_date: 2012-10-18T18:31:28Z

[Term]
id: GO:1901517
name: aspyridone A catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of aspyridone A." [GOC:di, GOC:TermGenie]
synonym: "aspyridone A breakdown" EXACT [GOC:TermGenie]
synonym: "aspyridone A catabolism" EXACT [GOC:TermGenie]
synonym: "aspyridone A degradation" EXACT [GOC:TermGenie]
is_a: GO:0030640 ! polyketide catabolic process
is_a: GO:0072526 ! pyridine-containing compound catabolic process
is_a: GO:1901516 ! aspyridone A metabolic process
created_by: di
creation_date: 2012-10-18T18:31:32Z

[Term]
id: GO:1901518
name: aspyridone A biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of aspyridone A." [GOC:di, GOC:TermGenie]
synonym: "aspyridone A anabolism" EXACT [GOC:TermGenie]
synonym: "aspyridone A biosynthesis" EXACT [GOC:TermGenie]
synonym: "aspyridone A formation" EXACT [GOC:TermGenie]
synonym: "aspyridone A synthesis" EXACT [GOC:TermGenie]
is_a: GO:0030639 ! polyketide biosynthetic process
is_a: GO:0072525 ! pyridine-containing compound biosynthetic process
is_a: GO:1901516 ! aspyridone A metabolic process
created_by: di
creation_date: 2012-10-18T18:31:36Z

[Term]
id: GO:1901519
name: aspyridone B metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aspyridone B." [GOC:di, GOC:TermGenie]
synonym: "aspyridone B metabolism" EXACT [GOC:TermGenie]
is_a: GO:0030638 ! polyketide metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0072524 ! pyridine-containing compound metabolic process
created_by: di
creation_date: 2012-10-18T18:31:40Z

[Term]
id: GO:1901520
name: aspyridone B catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of aspyridone B." [GOC:di, GOC:TermGenie]
synonym: "aspyridone B breakdown" EXACT [GOC:TermGenie]
synonym: "aspyridone B catabolism" EXACT [GOC:TermGenie]
synonym: "aspyridone B degradation" EXACT [GOC:TermGenie]
is_a: GO:0030640 ! polyketide catabolic process
is_a: GO:0072526 ! pyridine-containing compound catabolic process
is_a: GO:1901519 ! aspyridone B metabolic process
created_by: di
creation_date: 2012-10-18T18:31:44Z

[Term]
id: GO:1901521
name: aspyridone B biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of aspyridone B." [GOC:di, GOC:TermGenie]
synonym: "aspyridone B anabolism" EXACT [GOC:TermGenie]
synonym: "aspyridone B biosynthesis" EXACT [GOC:TermGenie]
synonym: "aspyridone B formation" EXACT [GOC:TermGenie]
synonym: "aspyridone B synthesis" EXACT [GOC:TermGenie]
is_a: GO:0030639 ! polyketide biosynthetic process
is_a: GO:0072525 ! pyridine-containing compound biosynthetic process
is_a: GO:1901519 ! aspyridone B metabolic process
created_by: di
creation_date: 2012-10-18T18:31:52Z

[Term]
id: GO:1901522
name: positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
namespace: biological_process
def: "Any positive regulation of transcription from RNA polymerase II promoter that is involved in cellular response to chemical stimulus." [GOC:TermGenie, PMID:22840777]
synonym: "activation of global transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" RELATED [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" NARROW [GOC:TermGenie]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription from Pol II promoter involved in cellular response to chemical stimulus" RELATED [GOC:TermGenie]
synonym: "positive regulation of transcription from Pol II promoter involved in cellular response to chemical stimulus" EXACT [GOC:TermGenie]
synonym: "stimulation of global transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" NARROW [GOC:TermGenie]
synonym: "stimulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" EXACT [GOC:TermGenie]
synonym: "up regulation of global transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" RELATED [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" EXACT [GOC:TermGenie]
synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" RELATED [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" EXACT [GOC:TermGenie]
synonym: "upregulation of global transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" RELATED [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" EXACT [GOC:TermGenie]
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
intersection_of: part_of GO:0070887 ! cellular response to chemical stimulus
relationship: part_of GO:0070887 ! cellular response to chemical stimulus
created_by: al
creation_date: 2012-10-19T08:25:05Z

[Term]
id: GO:1901523
name: icosanoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of icosanoid." [GOC:pr, GOC:TermGenie]
synonym: "icosanoid breakdown" EXACT [GOC:TermGenie]
synonym: "icosanoid catabolism" EXACT [GOC:TermGenie]
synonym: "icosanoid degradation" EXACT [GOC:TermGenie]
is_a: GO:0006690 ! icosanoid metabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process
is_a: GO:1901569 ! fatty acid derivative catabolic process
created_by: pr
creation_date: 2012-10-22T10:50:09Z

[Term]
id: GO:1901524
name: regulation of macromitophagy
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of macromitophagy." [GOC:TermGenie]
is_a: GO:1903146 ! regulation of mitophagy
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000423 ! macromitophagy
relationship: regulates GO:0000423 ! macromitophagy
created_by: krc
creation_date: 2012-10-22T16:56:45Z

[Term]
id: GO:1901525
name: negative regulation of macromitophagy
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of macromitophagy." [GOC:TermGenie]
synonym: "down regulation of macromitophagy" EXACT [GOC:TermGenie]
synonym: "down-regulation of macromitophagy" EXACT [GOC:TermGenie]
synonym: "downregulation of macromitophagy" EXACT [GOC:TermGenie]
synonym: "inhibition of macromitophagy" NARROW [GOC:TermGenie]
is_a: GO:1901524 ! regulation of macromitophagy
is_a: GO:1903147 ! negative regulation of mitophagy
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000423 ! macromitophagy
relationship: negatively_regulates GO:0000423 ! macromitophagy
created_by: krc
creation_date: 2012-10-22T16:56:49Z

[Term]
id: GO:1901526
name: positive regulation of macromitophagy
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of macromitophagy." [GOC:TermGenie]
synonym: "activation of macromitophagy" NARROW [GOC:TermGenie]
synonym: "up regulation of macromitophagy" EXACT [GOC:TermGenie]
synonym: "up-regulation of macromitophagy" EXACT [GOC:TermGenie]
synonym: "upregulation of macromitophagy" EXACT [GOC:TermGenie]
is_a: GO:1901524 ! regulation of macromitophagy
is_a: GO:1903599 ! positive regulation of mitophagy
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000423 ! macromitophagy
relationship: positively_regulates GO:0000423 ! macromitophagy
created_by: krc
creation_date: 2012-10-22T16:56:57Z

[Term]
id: GO:1901527
name: abscisic acid-activated signaling pathway involved in stomatal movement
namespace: biological_process
def: "Any abscisic acid mediated signaling pathway that is involved in stomatal movement." [GOC:TermGenie, PMID:22730405]
synonym: "abscisic acid mediated signaling pathway involved in stomatal movement" RELATED []
synonym: "abscisic acid mediated signalling involved in stomatal movement" EXACT [GOC:TermGenie]
is_a: GO:0009738 ! abscisic acid-activated signaling pathway
intersection_of: GO:0009738 ! abscisic acid-activated signaling pathway
intersection_of: part_of GO:0010118 ! stomatal movement
relationship: part_of GO:0010118 ! stomatal movement
created_by: tb
creation_date: 2012-10-23T23:09:34Z

[Term]
id: GO:1901528
name: hydrogen peroxide mediated signaling pathway involved in stomatal movement
namespace: biological_process
def: "Any hydrogen peroxide mediated signaling pathway that is involved in stomatal movement." [GOC:TermGenie]
synonym: "H2O2 mediated signaling pathway involved in stomatal movement" EXACT [GOC:TermGenie]
synonym: "hydrogen peroxide mediated signalling pathway involved in stomatal movement" EXACT [GOC:TermGenie]
is_a: GO:0071588 ! hydrogen peroxide mediated signaling pathway
intersection_of: GO:0071588 ! hydrogen peroxide mediated signaling pathway
intersection_of: part_of GO:0010118 ! stomatal movement
relationship: part_of GO:0010118 ! stomatal movement
created_by: tb
creation_date: 2012-10-23T23:15:25Z

[Term]
id: GO:1901529
name: positive regulation of anion channel activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of anion channel activity." [GOC:TermGenie]
synonym: "activation of anion channel activity" NARROW [GOC:TermGenie]
synonym: "up regulation of anion channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of anion channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of anion channel activity" EXACT [GOC:TermGenie]
is_a: GO:0010359 ! regulation of anion channel activity
is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity
is_a: GO:1903961 ! positive regulation of anion transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0005253 ! anion channel activity
relationship: positively_regulates GO:0005253 ! anion channel activity
created_by: tb
creation_date: 2012-10-23T23:38:50Z

[Term]
id: GO:1901530
name: response to hypochlorite
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hypochlorite stimulus." [GOC:pr, GOC:TermGenie, PMID:22223481]
is_a: GO:0000302 ! response to reactive oxygen species
is_a: GO:0001101 ! response to acid chemical
is_a: GO:0010035 ! response to inorganic substance
created_by: pr
creation_date: 2012-10-24T07:12:21Z

[Term]
id: GO:1901531
name: hypochlorite binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with hypochlorite." [GOC:pr, GOC:TermGenie, PMID:22223481]
is_a: GO:0043168 ! anion binding
created_by: pr
creation_date: 2012-10-24T07:15:22Z

[Term]
id: GO:1901532
name: regulation of hematopoietic progenitor cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hematopoietic progenitor cell differentiation." [GOC:BHF, GOC:rl, GOC:TermGenie]
synonym: "regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "regulation of hemopoietic progenitor cell differentiation" EXACT []
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:1903706 ! regulation of hemopoiesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002244 ! hematopoietic progenitor cell differentiation
relationship: regulates GO:0002244 ! hematopoietic progenitor cell differentiation
created_by: vk
creation_date: 2012-10-24T11:23:01Z

[Term]
id: GO:1901533
name: negative regulation of hematopoietic progenitor cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic progenitor cell differentiation." [GOC:BHF, GOC:rl, GOC:TermGenie]
synonym: "down regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie]
synonym: "down regulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie]
synonym: "down-regulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie]
synonym: "downregulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie]
synonym: "inhibition of hemopoietic progenitor cell differentiation" NARROW [GOC:TermGenie]
synonym: "negative regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "negative regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "negative regulation of hemopoietic progenitor cell differentiation" EXACT []
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:1901532 ! regulation of hematopoietic progenitor cell differentiation
is_a: GO:1903707 ! negative regulation of hemopoiesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002244 ! hematopoietic progenitor cell differentiation
relationship: negatively_regulates GO:0002244 ! hematopoietic progenitor cell differentiation
created_by: vk
creation_date: 2012-10-24T11:23:06Z

[Term]
id: GO:1901534
name: positive regulation of hematopoietic progenitor cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hematopoietic progenitor cell differentiation." [GOC:BHF, GOC:rl, GOC:TermGenie]
synonym: "activation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "activation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "activation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie]
synonym: "activation of hemopoietic progenitor cell differentiation" NARROW [GOC:TermGenie]
synonym: "positive regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of hemopoietic progenitor cell differentiation" EXACT []
synonym: "up regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie]
synonym: "up regulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie]
synonym: "up-regulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie]
synonym: "upregulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:1901532 ! regulation of hematopoietic progenitor cell differentiation
is_a: GO:1903708 ! positive regulation of hemopoiesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002244 ! hematopoietic progenitor cell differentiation
relationship: positively_regulates GO:0002244 ! hematopoietic progenitor cell differentiation
created_by: vk
creation_date: 2012-10-24T11:23:14Z

[Term]
id: GO:1901535
name: regulation of DNA demethylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA demethylation." [GOC:TermGenie]
is_a: GO:0051052 ! regulation of DNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0080111 ! DNA demethylation
relationship: regulates GO:0080111 ! DNA demethylation
created_by: jl
creation_date: 2012-10-24T13:52:50Z

[Term]
id: GO:1901536
name: negative regulation of DNA demethylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA demethylation." [GOC:TermGenie]
synonym: "down regulation of DNA demethylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA demethylation" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA demethylation" EXACT [GOC:TermGenie]
synonym: "inhibition of DNA demethylation" NARROW [GOC:TermGenie]
is_a: GO:0051053 ! negative regulation of DNA metabolic process
is_a: GO:1901535 ! regulation of DNA demethylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0080111 ! DNA demethylation
relationship: negatively_regulates GO:0080111 ! DNA demethylation
created_by: jl
creation_date: 2012-10-24T13:52:54Z

[Term]
id: GO:1901537
name: positive regulation of DNA demethylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA demethylation." [GOC:TermGenie]
synonym: "activation of DNA demethylation" NARROW [GOC:TermGenie]
synonym: "up regulation of DNA demethylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA demethylation" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA demethylation" EXACT [GOC:TermGenie]
is_a: GO:0051054 ! positive regulation of DNA metabolic process
is_a: GO:1901535 ! regulation of DNA demethylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0080111 ! DNA demethylation
relationship: positively_regulates GO:0080111 ! DNA demethylation
created_by: jl
creation_date: 2012-10-24T13:52:59Z

[Term]
id: GO:1901538
name: changes to DNA methylation involved in embryo development
namespace: biological_process
def: "The addition or removal of methyl groups to DNA that contributes to the epigenetic regulation of embryonic gene expression." [GOC:TermGenie]
synonym: "changes in DNA methylation involved in embryo development" EXACT [GOC:TermGenie]
synonym: "changes in DNA methylation involved in embryogenesis" EXACT [GOC:TermGenie]
synonym: "changes in DNA methylation involved in embryonal development" RELATED [GOC:TermGenie]
synonym: "DNA methylation or demethylation involved in embryogenesis" EXACT [GOC:TermGenie]
synonym: "DNA methylation or demethylation involved in embryonal development" EXACT [GOC:TermGenie]
is_a: GO:0044728 ! DNA methylation or demethylation
intersection_of: GO:0044728 ! DNA methylation or demethylation
intersection_of: part_of GO:0009790 ! embryo development
relationship: part_of GO:0009790 ! embryo development
created_by: jl
creation_date: 2012-10-25T14:53:43Z

[Term]
id: GO:1901539
name: ent-pimara-8(14),15-diene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ent-pimara-8(14),15-diene." [GOC:di, GOC:TermGenie]
synonym: "ent-pimara-8(14),15-diene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0042214 ! terpene metabolic process
created_by: di
creation_date: 2012-10-25T15:38:13Z

[Term]
id: GO:1901540
name: ent-pimara-8(14),15-diene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ent-pimara-8(14),15-diene." [GOC:di, GOC:TermGenie]
synonym: "ent-pimara-8(14),15-diene breakdown" EXACT [GOC:TermGenie]
synonym: "ent-pimara-8(14),15-diene catabolism" EXACT [GOC:TermGenie]
synonym: "ent-pimara-8(14),15-diene degradation" EXACT [GOC:TermGenie]
is_a: GO:0046247 ! terpene catabolic process
is_a: GO:1901539 ! ent-pimara-8(14),15-diene metabolic process
created_by: di
creation_date: 2012-10-25T15:38:17Z

[Term]
id: GO:1901541
name: ent-pimara-8(14),15-diene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ent-pimara-8(14),15-diene." [GOC:di, GOC:TermGenie]
synonym: "ent-pimara-8(14),15-diene anabolism" EXACT [GOC:TermGenie]
synonym: "ent-pimara-8(14),15-diene biosynthesis" EXACT [GOC:TermGenie]
synonym: "ent-pimara-8(14),15-diene formation" EXACT [GOC:TermGenie]
synonym: "ent-pimara-8(14),15-diene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046246 ! terpene biosynthetic process
is_a: GO:1901539 ! ent-pimara-8(14),15-diene metabolic process
created_by: di
creation_date: 2012-10-25T15:38:21Z

[Term]
id: GO:1901542
name: regulation of ent-pimara-8(14),15-diene biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ent-pimara-8(14),15-diene biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of ent-pimara-8(14),15-diene anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of ent-pimara-8(14),15-diene biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of ent-pimara-8(14),15-diene formation" EXACT [GOC:TermGenie]
synonym: "regulation of ent-pimara-8(14),15-diene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0019747 ! regulation of isoprenoid metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0046890 ! regulation of lipid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1901541 ! ent-pimara-8(14),15-diene biosynthetic process
relationship: regulates GO:1901541 ! ent-pimara-8(14),15-diene biosynthetic process
created_by: di
creation_date: 2012-10-26T11:37:54Z

[Term]
id: GO:1901543
name: negative regulation of ent-pimara-8(14),15-diene biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ent-pimara-8(14),15-diene biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of ent-pimara-8(14),15-diene anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of ent-pimara-8(14),15-diene biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of ent-pimara-8(14),15-diene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of ent-pimara-8(14),15-diene formation" EXACT [GOC:TermGenie]
synonym: "down regulation of ent-pimara-8(14),15-diene synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of ent-pimara-8(14),15-diene anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of ent-pimara-8(14),15-diene biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of ent-pimara-8(14),15-diene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of ent-pimara-8(14),15-diene formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of ent-pimara-8(14),15-diene synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of ent-pimara-8(14),15-diene anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of ent-pimara-8(14),15-diene biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of ent-pimara-8(14),15-diene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of ent-pimara-8(14),15-diene formation" EXACT [GOC:TermGenie]
synonym: "downregulation of ent-pimara-8(14),15-diene synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of ent-pimara-8(14),15-diene anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of ent-pimara-8(14),15-diene biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of ent-pimara-8(14),15-diene biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of ent-pimara-8(14),15-diene formation" NARROW [GOC:TermGenie]
synonym: "inhibition of ent-pimara-8(14),15-diene synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of ent-pimara-8(14),15-diene anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of ent-pimara-8(14),15-diene biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of ent-pimara-8(14),15-diene formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of ent-pimara-8(14),15-diene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0045827 ! negative regulation of isoprenoid metabolic process
is_a: GO:0051055 ! negative regulation of lipid biosynthetic process
is_a: GO:1901542 ! regulation of ent-pimara-8(14),15-diene biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1901541 ! ent-pimara-8(14),15-diene biosynthetic process
relationship: negatively_regulates GO:1901541 ! ent-pimara-8(14),15-diene biosynthetic process
created_by: di
creation_date: 2012-10-26T11:37:58Z

[Term]
id: GO:1901544
name: positive regulation of ent-pimara-8(14),15-diene biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ent-pimara-8(14),15-diene biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of ent-pimara-8(14),15-diene anabolism" NARROW [GOC:TermGenie]
synonym: "activation of ent-pimara-8(14),15-diene biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of ent-pimara-8(14),15-diene biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of ent-pimara-8(14),15-diene formation" NARROW [GOC:TermGenie]
synonym: "activation of ent-pimara-8(14),15-diene synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of ent-pimara-8(14),15-diene anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of ent-pimara-8(14),15-diene biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of ent-pimara-8(14),15-diene formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of ent-pimara-8(14),15-diene synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of ent-pimara-8(14),15-diene anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of ent-pimara-8(14),15-diene biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of ent-pimara-8(14),15-diene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of ent-pimara-8(14),15-diene formation" EXACT [GOC:TermGenie]
synonym: "up regulation of ent-pimara-8(14),15-diene synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of ent-pimara-8(14),15-diene anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of ent-pimara-8(14),15-diene biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of ent-pimara-8(14),15-diene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of ent-pimara-8(14),15-diene formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of ent-pimara-8(14),15-diene synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of ent-pimara-8(14),15-diene anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of ent-pimara-8(14),15-diene biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of ent-pimara-8(14),15-diene biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of ent-pimara-8(14),15-diene formation" EXACT [GOC:TermGenie]
synonym: "upregulation of ent-pimara-8(14),15-diene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process
is_a: GO:0046889 ! positive regulation of lipid biosynthetic process
is_a: GO:1901542 ! regulation of ent-pimara-8(14),15-diene biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1901541 ! ent-pimara-8(14),15-diene biosynthetic process
relationship: positively_regulates GO:1901541 ! ent-pimara-8(14),15-diene biosynthetic process
created_by: di
creation_date: 2012-10-26T11:38:07Z

[Term]
id: GO:1901545
name: response to raffinose
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a raffinose stimulus." [GOC:TermGenie]
is_a: GO:0009743 ! response to carbohydrate
created_by: al
creation_date: 2012-10-26T14:32:23Z

[Term]
id: GO:1901546
name: regulation of synaptic vesicle lumen acidification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synaptic vesicle lumen acidification." [GOC:TermGenie]
synonym: "regulation of synaptic vesicle lumen pH reduction" EXACT [GOC:TermGenie]
is_a: GO:0032847 ! regulation of cellular pH reduction
is_a: GO:0033043 ! regulation of organelle organization
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0051049 ! regulation of transport
is_a: GO:0060341 ! regulation of cellular localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097401 ! synaptic vesicle lumen acidification
relationship: regulates GO:0097401 ! synaptic vesicle lumen acidification
created_by: dsf
creation_date: 2012-10-26T16:09:24Z

[Term]
id: GO:1901547
name: negative regulation of synaptic vesicle lumen acidification
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle lumen acidification." [GOC:TermGenie]
synonym: "down regulation of synaptic vesicle lumen acidification" EXACT [GOC:TermGenie]
synonym: "down regulation of synaptic vesicle lumen pH reduction" EXACT [GOC:TermGenie]
synonym: "down-regulation of synaptic vesicle lumen acidification" EXACT [GOC:TermGenie]
synonym: "down-regulation of synaptic vesicle lumen pH reduction" EXACT [GOC:TermGenie]
synonym: "downregulation of synaptic vesicle lumen acidification" EXACT [GOC:TermGenie]
synonym: "downregulation of synaptic vesicle lumen pH reduction" EXACT [GOC:TermGenie]
synonym: "inhibition of synaptic vesicle lumen acidification" NARROW [GOC:TermGenie]
synonym: "inhibition of synaptic vesicle lumen pH reduction" NARROW [GOC:TermGenie]
synonym: "negative regulation of synaptic vesicle lumen pH reduction" EXACT [GOC:TermGenie]
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:0032848 ! negative regulation of cellular pH reduction
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:1900243 ! negative regulation of synaptic vesicle endocytosis
is_a: GO:1901546 ! regulation of synaptic vesicle lumen acidification
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097401 ! synaptic vesicle lumen acidification
relationship: negatively_regulates GO:0097401 ! synaptic vesicle lumen acidification
created_by: dsf
creation_date: 2012-10-26T16:09:28Z

[Term]
id: GO:1901548
name: positive regulation of synaptic vesicle lumen acidification
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of synaptic vesicle lumen acidification." [GOC:TermGenie]
synonym: "activation of synaptic vesicle lumen acidification" NARROW [GOC:TermGenie]
synonym: "activation of synaptic vesicle lumen pH reduction" NARROW [GOC:TermGenie]
synonym: "positive regulation of synaptic vesicle lumen pH reduction" EXACT [GOC:TermGenie]
synonym: "up regulation of synaptic vesicle lumen acidification" EXACT [GOC:TermGenie]
synonym: "up regulation of synaptic vesicle lumen pH reduction" EXACT [GOC:TermGenie]
synonym: "up-regulation of synaptic vesicle lumen acidification" EXACT [GOC:TermGenie]
synonym: "up-regulation of synaptic vesicle lumen pH reduction" EXACT [GOC:TermGenie]
synonym: "upregulation of synaptic vesicle lumen acidification" EXACT [GOC:TermGenie]
synonym: "upregulation of synaptic vesicle lumen pH reduction" EXACT [GOC:TermGenie]
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:0032849 ! positive regulation of cellular pH reduction
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:1900244 ! positive regulation of synaptic vesicle endocytosis
is_a: GO:1901546 ! regulation of synaptic vesicle lumen acidification
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097401 ! synaptic vesicle lumen acidification
relationship: positively_regulates GO:0097401 ! synaptic vesicle lumen acidification
created_by: dsf
creation_date: 2012-10-26T16:09:32Z

[Term]
id: GO:1901549
name: malonic acid uptake transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of malonic acid from the outside of a cell to the inside across a membrane." [GOC:TermGenie]
is_a: GO:0015563 ! uptake transmembrane transporter activity
is_a: GO:1901239 ! malonate(1-) transmembrane transporter activity
created_by: al
creation_date: 2012-10-30T11:47:13Z

[Term]
id: GO:1901550
name: regulation of endothelial cell development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endothelial cell development." [GOC:pr, GOC:TermGenie, PMID:19470579]
is_a: GO:0045601 ! regulation of endothelial cell differentiation
is_a: GO:0060284 ! regulation of cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001885 ! endothelial cell development
relationship: regulates GO:0001885 ! endothelial cell development
created_by: pr
creation_date: 2012-10-30T12:59:50Z

[Term]
id: GO:1901551
name: negative regulation of endothelial cell development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell development." [GOC:pr, GOC:TermGenie, PMID:19470579]
synonym: "down regulation of endothelial cell development" EXACT [GOC:TermGenie]
synonym: "down-regulation of endothelial cell development" EXACT [GOC:TermGenie]
synonym: "downregulation of endothelial cell development" EXACT [GOC:TermGenie]
synonym: "inhibition of endothelial cell development" NARROW [GOC:TermGenie]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0045602 ! negative regulation of endothelial cell differentiation
is_a: GO:1901550 ! regulation of endothelial cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001885 ! endothelial cell development
relationship: negatively_regulates GO:0001885 ! endothelial cell development
created_by: pr
creation_date: 2012-10-30T12:59:54Z

[Term]
id: GO:1901552
name: positive regulation of endothelial cell development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endothelial cell development." [GOC:pr, GOC:TermGenie, PMID:19470579]
synonym: "activation of endothelial cell development" NARROW [GOC:TermGenie]
synonym: "up regulation of endothelial cell development" EXACT [GOC:TermGenie]
synonym: "up-regulation of endothelial cell development" EXACT [GOC:TermGenie]
synonym: "upregulation of endothelial cell development" EXACT [GOC:TermGenie]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0045603 ! positive regulation of endothelial cell differentiation
is_a: GO:1901550 ! regulation of endothelial cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001885 ! endothelial cell development
relationship: positively_regulates GO:0001885 ! endothelial cell development
created_by: pr
creation_date: 2012-10-30T12:59:58Z

[Term]
id: GO:1901553
name: malonic acid transmembrane transport
namespace: biological_process
def: "The directed movement of malonic acid across a membrane." [GOC:al, GOC:TermGenie]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "malonic acid membrane transport" EXACT []
is_a: GO:1900752 ! malonic acid transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport
created_by: pr
creation_date: 2012-10-30T15:23:54Z

[Term]
id: GO:1901554
name: response to paracetamol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a paracetamol stimulus." [GOC:TermGenie]
synonym: "response to acetaminophen" EXACT []
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: hp
creation_date: 2012-11-02T09:43:23Z

[Term]
id: GO:1901555
name: response to paclitaxel
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a paclitaxel stimulus." [GOC:TermGenie]
is_a: GO:0033993 ! response to lipid
created_by: hp
creation_date: 2012-11-02T09:46:08Z

[Term]
id: GO:1901556
name: response to candesartan
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a candesartan stimulus." [GOC:TermGenie]
is_a: GO:0001101 ! response to acid chemical
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: hp
creation_date: 2012-11-02T09:46:13Z

[Term]
id: GO:1901557
name: response to fenofibrate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fenofibrate stimulus." [GOC:TermGenie]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0045472 ! response to ether
is_a: GO:1901654 ! response to ketone
created_by: hp
creation_date: 2012-11-02T09:46:20Z

[Term]
id: GO:1901558
name: response to metformin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metformin stimulus." [GOC:TermGenie]
is_a: GO:0010243 ! response to organonitrogen compound
created_by: hp
creation_date: 2012-11-02T09:46:24Z

[Term]
id: GO:1901559
name: response to ribavirin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ribavirin stimulus." [GOC:TermGenie]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: hp
creation_date: 2012-11-02T09:46:28Z

[Term]
id: GO:1901560
name: response to purvalanol A
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purvalanol A stimulus." [GOC:TermGenie]
is_a: GO:0014074 ! response to purine-containing compound
created_by: mah
creation_date: 2012-11-02T15:32:28Z

[Term]
id: GO:1901561
name: response to benomyl
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benomyl stimulus." [GOC:TermGenie]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: mah
creation_date: 2012-11-02T15:32:33Z

[Term]
id: GO:1901562
name: response to paraquat
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a paraquat stimulus." [GOC:TermGenie]
is_a: GO:0010033 ! response to organic substance
created_by: mah
creation_date: 2012-11-02T15:32:41Z

[Term]
id: GO:1901563
name: response to camptothecin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a camptothecin stimulus." [GOC:TermGenie]
synonym: "response to CPT" EXACT [GOC:mah]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0043279 ! response to alkaloid
is_a: GO:0097305 ! response to alcohol
created_by: mah
creation_date: 2012-11-02T15:32:45Z

[Term]
id: GO:1901564
name: organonitrogen compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving organonitrogen compound." [GOC:pr, GOC:TermGenie]
synonym: "organonitrogen compound metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006807 ! nitrogen compound metabolic process
is_a: GO:0071704 ! organic substance metabolic process
created_by: pr
creation_date: 2012-11-04T15:17:52Z

[Term]
id: GO:1901565
name: organonitrogen compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of organonitrogen compound." [GOC:pr, GOC:TermGenie]
synonym: "organonitrogen compound breakdown" EXACT [GOC:TermGenie]
synonym: "organonitrogen compound catabolism" EXACT [GOC:TermGenie]
synonym: "organonitrogen compound degradation" EXACT [GOC:TermGenie]
is_a: GO:1901564 ! organonitrogen compound metabolic process
is_a: GO:1901575 ! organic substance catabolic process
created_by: pr
creation_date: 2012-11-04T15:17:56Z

[Term]
id: GO:1901566
name: organonitrogen compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of organonitrogen compound." [GOC:pr, GOC:TermGenie]
synonym: "organonitrogen compound anabolism" EXACT [GOC:TermGenie]
synonym: "organonitrogen compound biosynthesis" EXACT [GOC:TermGenie]
synonym: "organonitrogen compound formation" EXACT [GOC:TermGenie]
synonym: "organonitrogen compound synthesis" EXACT [GOC:TermGenie]
is_a: GO:1901564 ! organonitrogen compound metabolic process
is_a: GO:1901576 ! organic substance biosynthetic process
created_by: pr
creation_date: 2012-11-04T15:18:00Z

[Term]
id: GO:1901567
name: fatty acid derivative binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with fatty acid derivative." [GOC:pr, GOC:TermGenie]
is_a: GO:0005488 ! binding
created_by: pr
creation_date: 2012-11-04T17:13:28Z

[Term]
id: GO:1901568
name: fatty acid derivative metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fatty acid derivative." [GOC:pr, GOC:TermGenie]
synonym: "fatty acid derivative metabolism" EXACT [GOC:TermGenie]
is_a: GO:0044710 ! single-organism metabolic process
is_a: GO:0071704 ! organic substance metabolic process
created_by: pr
creation_date: 2012-11-04T17:13:36Z

[Term]
id: GO:1901569
name: fatty acid derivative catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of fatty acid derivative." [GOC:pr, GOC:TermGenie]
synonym: "fatty acid derivative breakdown" EXACT [GOC:TermGenie]
synonym: "fatty acid derivative catabolism" EXACT [GOC:TermGenie]
synonym: "fatty acid derivative degradation" EXACT [GOC:TermGenie]
is_a: GO:0044712 ! single-organism catabolic process
is_a: GO:1901568 ! fatty acid derivative metabolic process
is_a: GO:1901575 ! organic substance catabolic process
created_by: pr
creation_date: 2012-11-04T17:13:40Z

[Term]
id: GO:1901570
name: fatty acid derivative biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of fatty acid derivative." [GOC:pr, GOC:TermGenie]
synonym: "fatty acid derivative anabolism" EXACT [GOC:TermGenie]
synonym: "fatty acid derivative biosynthesis" EXACT [GOC:TermGenie]
synonym: "fatty acid derivative formation" EXACT [GOC:TermGenie]
synonym: "fatty acid derivative synthesis" EXACT [GOC:TermGenie]
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:1901568 ! fatty acid derivative metabolic process
is_a: GO:1901576 ! organic substance biosynthetic process
created_by: pr
creation_date: 2012-11-04T17:13:44Z

[Term]
id: GO:1901571
name: fatty acid derivative transport
namespace: biological_process
def: "The directed movement of a fatty acid derivative into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:pr, GOC:TermGenie]
is_a: GO:0044765 ! single-organism transport
is_a: GO:0071702 ! organic substance transport
created_by: pr
creation_date: 2012-11-04T17:13:49Z

[Term]
id: GO:1901572
name: obsolete chemical substance metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving chemical substance." [GOC:pr, GOC:TermGenie]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "chemical substance metabolic process" EXACT []
synonym: "chemical substance metabolism" EXACT [GOC:TermGenie]
is_obsolete: true
created_by: pr
creation_date: 2012-11-04T18:10:32Z

[Term]
id: GO:1901573
name: obsolete chemical substance catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of chemical substance." [GOC:pr, GOC:TermGenie]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "chemical substance breakdown" EXACT [GOC:TermGenie]
synonym: "chemical substance catabolic process" EXACT []
synonym: "chemical substance catabolism" EXACT [GOC:TermGenie]
synonym: "chemical substance degradation" EXACT [GOC:TermGenie]
is_obsolete: true
created_by: pr
creation_date: 2012-11-04T18:10:36Z

[Term]
id: GO:1901574
name: obsolete chemical substance biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of chemical substance." [GOC:pr, GOC:TermGenie]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "chemical substance anabolism" EXACT [GOC:TermGenie]
synonym: "chemical substance biosynthesis" EXACT [GOC:TermGenie]
synonym: "chemical substance biosynthetic process" EXACT []
synonym: "chemical substance formation" EXACT [GOC:TermGenie]
synonym: "chemical substance synthesis" EXACT [GOC:TermGenie]
is_obsolete: true
created_by: pr
creation_date: 2012-11-04T18:10:40Z

[Term]
id: GO:1901575
name: organic substance catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of an organic substance, any molecular entity containing carbon." [GOC:pr, GOC:TermGenie]
synonym: "organic molecular entity breakdown" EXACT [GOC:TermGenie]
synonym: "organic molecular entity catabolic process" EXACT []
synonym: "organic molecular entity catabolism" EXACT [GOC:TermGenie]
synonym: "organic molecular entity degradation" EXACT [GOC:TermGenie]
synonym: "organic substance breakdown" EXACT []
synonym: "organic substance catabolism" EXACT []
synonym: "organic substance degradation" EXACT []
is_a: GO:0009056 ! catabolic process
is_a: GO:0071704 ! organic substance metabolic process
created_by: pr
creation_date: 2012-11-05T11:04:36Z

[Term]
id: GO:1901576
name: organic substance biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an organic substance, any molecular entity containing carbon." [GOC:pr, GOC:TermGenie]
synonym: "organic molecular entity anabolism" EXACT [GOC:TermGenie]
synonym: "organic molecular entity biosynthesis" EXACT [GOC:TermGenie]
synonym: "organic molecular entity biosynthetic process" EXACT []
synonym: "organic molecular entity formation" EXACT [GOC:TermGenie]
synonym: "organic molecular entity synthesis" EXACT [GOC:TermGenie]
synonym: "organic substance anabolism" EXACT []
synonym: "organic substance biosynthesis" EXACT []
synonym: "organic substance formation" EXACT []
synonym: "organic substance synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0071704 ! organic substance metabolic process
created_by: pr
creation_date: 2012-11-05T11:04:40Z

[Term]
id: GO:1901577
name: regulation of alkane biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of alkane biosynthetic process." [GOC:TermGenie]
synonym: "regulation of alkane anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of alkane biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of alkane formation" EXACT [GOC:TermGenie]
synonym: "regulation of alkane synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043447 ! alkane biosynthetic process
relationship: regulates GO:0043447 ! alkane biosynthetic process
created_by: dhl
creation_date: 2012-11-05T21:54:06Z

[Term]
id: GO:1901578
name: negative regulation of alkane biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of alkane biosynthetic process." [GOC:TermGenie]
synonym: "down regulation of alkane anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of alkane biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of alkane biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of alkane formation" EXACT [GOC:TermGenie]
synonym: "down regulation of alkane synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of alkane anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of alkane biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of alkane biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of alkane formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of alkane synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of alkane anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of alkane biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of alkane biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of alkane formation" EXACT [GOC:TermGenie]
synonym: "downregulation of alkane synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of alkane anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of alkane biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of alkane biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of alkane formation" EXACT [GOC:TermGenie]
synonym: "inhibition of alkane synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of alkane anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of alkane biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of alkane formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of alkane synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:1901577 ! regulation of alkane biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043447 ! alkane biosynthetic process
relationship: negatively_regulates GO:0043447 ! alkane biosynthetic process
created_by: dhl
creation_date: 2012-11-05T21:54:11Z

[Term]
id: GO:1901579
name: positive regulation of alkane biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of alkane biosynthetic process." [GOC:TermGenie]
synonym: "activation of alkane anabolism" EXACT [GOC:TermGenie]
synonym: "activation of alkane biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of alkane biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of alkane formation" EXACT [GOC:TermGenie]
synonym: "activation of alkane synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of alkane anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of alkane biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of alkane formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of alkane synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of alkane anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of alkane biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of alkane biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of alkane formation" EXACT [GOC:TermGenie]
synonym: "up regulation of alkane synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of alkane anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of alkane biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of alkane biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of alkane formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of alkane synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of alkane anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of alkane biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of alkane biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of alkane formation" EXACT [GOC:TermGenie]
synonym: "upregulation of alkane synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:1901577 ! regulation of alkane biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043447 ! alkane biosynthetic process
relationship: positively_regulates GO:0043447 ! alkane biosynthetic process
created_by: dhl
creation_date: 2012-11-05T21:54:19Z

[Term]
id: GO:1901580
name: regulation of telomeric RNA transcription from RNA pol II promoter
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of telomeric RNA transcription from RNA pol II promoter." [GOC:TermGenie]
synonym: "regulation of telomeric RNA transcription from Pol II promoter" EXACT [GOC:TermGenie]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097394 ! telomeric repeat-containing RNA transcription from RNA pol II promoter
relationship: regulates GO:0097394 ! telomeric repeat-containing RNA transcription from RNA pol II promoter
created_by: al
creation_date: 2012-11-06T11:07:16Z

[Term]
id: GO:1901581
name: negative regulation of telomeric RNA transcription from RNA pol II promoter
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of telomeric RNA transcription from RNA pol II promoter." [GOC:TermGenie]
synonym: "down regulation of telomeric RNA transcription from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "down regulation of telomeric RNA transcription from RNA pol II promoter" EXACT [GOC:TermGenie]
synonym: "down-regulation of telomeric RNA transcription from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "down-regulation of telomeric RNA transcription from RNA pol II promoter" EXACT [GOC:TermGenie]
synonym: "downregulation of telomeric RNA transcription from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "downregulation of telomeric RNA transcription from RNA pol II promoter" EXACT [GOC:TermGenie]
synonym: "inhibition of telomeric RNA transcription from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "inhibition of telomeric RNA transcription from RNA pol II promoter" NARROW [GOC:TermGenie]
synonym: "negative regulation of telomeric RNA transcription from Pol II promoter" EXACT [GOC:TermGenie]
is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
is_a: GO:1901580 ! regulation of telomeric RNA transcription from RNA pol II promoter
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097394 ! telomeric repeat-containing RNA transcription from RNA pol II promoter
relationship: negatively_regulates GO:0097394 ! telomeric repeat-containing RNA transcription from RNA pol II promoter
created_by: al
creation_date: 2012-11-06T11:07:21Z

[Term]
id: GO:1901582
name: positive regulation of telomeric RNA transcription from RNA pol II promoter
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of telomeric RNA transcription from RNA pol II promoter." [GOC:TermGenie]
synonym: "activation of telomeric RNA transcription from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "activation of telomeric RNA transcription from RNA pol II promoter" NARROW [GOC:TermGenie]
synonym: "positive regulation of telomeric RNA transcription from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of telomeric RNA transcription from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of telomeric RNA transcription from RNA pol II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of telomeric RNA transcription from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of telomeric RNA transcription from RNA pol II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of telomeric RNA transcription from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of telomeric RNA transcription from RNA pol II promoter" EXACT [GOC:TermGenie]
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
is_a: GO:1901580 ! regulation of telomeric RNA transcription from RNA pol II promoter
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097394 ! telomeric repeat-containing RNA transcription from RNA pol II promoter
relationship: positively_regulates GO:0097394 ! telomeric repeat-containing RNA transcription from RNA pol II promoter
created_by: al
creation_date: 2012-11-06T11:07:25Z

[Term]
id: GO:1901583
name: tetrapeptide transmembrane transport
namespace: biological_process
def: "The directed movement of tetrapeptide across a membrane." [GOC:TermGenie]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "tetrapeptide membrane transport" EXACT []
is_a: GO:0035672 ! oligopeptide transmembrane transport
created_by: jl
creation_date: 2012-11-06T15:40:02Z

[Term]
id: GO:1901584
name: tetrapeptide transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of tetrapeptide from one side of the membrane to the other." [GOC:TermGenie]
is_a: GO:0035673 ! oligopeptide transmembrane transporter activity
relationship: part_of GO:1901583 ! tetrapeptide transmembrane transport
created_by: jl
creation_date: 2012-11-06T15:40:10Z

[Term]
id: GO:1901585
name: regulation of acid-sensing ion channel activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of acid-sensing ion channel activity." [GOC:TermGenie]
synonym: "regulation of ASIC activity" EXACT [GOC:TermGenie]
is_a: GO:0010469 ! regulation of receptor activity
is_a: GO:2000649 ! regulation of sodium ion transmembrane transporter activity
is_a: GO:2001257 ! regulation of cation channel activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044736 ! acid-sensing ion channel activity
relationship: regulates GO:0044736 ! acid-sensing ion channel activity
created_by: jl
creation_date: 2012-11-07T13:37:24Z

[Term]
id: GO:1901586
name: negative regulation of acid-sensing ion channel activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of acid-sensing ion channel activity." [GOC:TermGenie]
synonym: "down regulation of acid-sensing ion channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of ASIC activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of acid-sensing ion channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of ASIC activity" EXACT [GOC:TermGenie]
synonym: "downregulation of acid-sensing ion channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of ASIC activity" EXACT [GOC:TermGenie]
synonym: "inhibition of acid-sensing ion channel activity" NARROW [GOC:TermGenie]
synonym: "inhibition of ASIC activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of ASIC activity" EXACT [GOC:TermGenie]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:1901585 ! regulation of acid-sensing ion channel activity
is_a: GO:2000272 ! negative regulation of receptor activity
is_a: GO:2000650 ! negative regulation of sodium ion transmembrane transporter activity
is_a: GO:2001258 ! negative regulation of cation channel activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044736 ! acid-sensing ion channel activity
relationship: negatively_regulates GO:0044736 ! acid-sensing ion channel activity
created_by: jl
creation_date: 2012-11-07T13:37:32Z

[Term]
id: GO:1901587
name: positive regulation of acid-sensing ion channel activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of acid-sensing ion channel activity." [GOC:TermGenie]
synonym: "activation of acid-sensing ion channel activity" NARROW [GOC:TermGenie]
synonym: "activation of ASIC activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of ASIC activity" EXACT [GOC:TermGenie]
synonym: "up regulation of acid-sensing ion channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of ASIC activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of acid-sensing ion channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of ASIC activity" EXACT [GOC:TermGenie]
synonym: "upregulation of acid-sensing ion channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of ASIC activity" EXACT [GOC:TermGenie]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:1901585 ! regulation of acid-sensing ion channel activity
is_a: GO:2000273 ! positive regulation of receptor activity
is_a: GO:2000651 ! positive regulation of sodium ion transmembrane transporter activity
is_a: GO:2001259 ! positive regulation of cation channel activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044736 ! acid-sensing ion channel activity
relationship: positively_regulates GO:0044736 ! acid-sensing ion channel activity
created_by: jl
creation_date: 2012-11-07T13:37:37Z

[Term]
id: GO:1901588
name: dendritic microtubule
namespace: cellular_component
def: "Any microtubule in a dendrite, a neuron projection." [GOC:TermGenie, NIF_Subcellular:sao110773650]
synonym: "microtubule of dendrite" EXACT [GOC:TermGenie]
synonym: "microtubulus of dendrite" EXACT [GOC:TermGenie]
xref: NIF_Subcellular:sao110773650
is_a: GO:0005874 ! microtubule
is_a: GO:0044463 ! cell projection part
is_a: GO:0097458 ! neuron part
intersection_of: GO:0005874 ! microtubule
intersection_of: part_of GO:0030425 ! dendrite
relationship: part_of GO:0030425 ! dendrite
created_by: pr
creation_date: 2012-11-07T14:37:30Z

[Term]
id: GO:1901589
name: axon microtubule bundle
namespace: cellular_component
def: "An arrangement of closely apposed microtubules running parallel to each other in the axon hillock and initial segment." [GOC:TermGenie, NIF_Subcellular:sao707332678]
synonym: "axon microtubule fascicle" EXACT []
synonym: "microtubule bundle of axon" EXACT [GOC:TermGenie]
synonym: "microtubule fascicle of axon" EXACT [GOC:TermGenie]
xref: NIF_Subcellular:sao707332678
is_a: GO:0033267 ! axon part
is_a: GO:0097427 ! microtubule bundle
intersection_of: GO:0097427 ! microtubule bundle
intersection_of: part_of GO:0030424 ! axon
relationship: part_of GO:0030424 ! axon
created_by: pr
creation_date: 2012-11-07T15:37:12Z

[Term]
id: GO:1901591
name: regulation of double-strand break repair via break-induced replication
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of double-strand break repair via break-induced replication." [GOC:TermGenie]
is_a: GO:0010569 ! regulation of double-strand break repair via homologous recombination
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000727 ! double-strand break repair via break-induced replication
relationship: regulates GO:0000727 ! double-strand break repair via break-induced replication
created_by: al
creation_date: 2012-11-07T16:37:34Z

[Term]
id: GO:1901592
name: negative regulation of double-strand break repair via break-induced replication
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of double-strand break repair via break-induced replication." [GOC:TermGenie]
synonym: "down regulation of double-strand break repair via break-induced replication" EXACT [GOC:TermGenie]
synonym: "down-regulation of double-strand break repair via break-induced replication" EXACT [GOC:TermGenie]
synonym: "downregulation of double-strand break repair via break-induced replication" EXACT [GOC:TermGenie]
synonym: "inhibition of double-strand break repair via break-induced replication" NARROW [GOC:TermGenie]
is_a: GO:1901591 ! regulation of double-strand break repair via break-induced replication
is_a: GO:2000042 ! negative regulation of double-strand break repair via homologous recombination
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000727 ! double-strand break repair via break-induced replication
relationship: negatively_regulates GO:0000727 ! double-strand break repair via break-induced replication
created_by: al
creation_date: 2012-11-07T16:37:39Z

[Term]
id: GO:1901593
name: response to GW 7647
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a GW 7647 stimulus." [GOC:TermGenie]
is_a: GO:0001101 ! response to acid chemical
is_a: GO:0010033 ! response to organic substance
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: mah
creation_date: 2012-11-07T17:16:48Z

[Term]
id: GO:1901594
name: response to capsazepine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a capsazepine stimulus." [GOC:TermGenie]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: mah
creation_date: 2012-11-07T17:16:53Z

[Term]
id: GO:1901595
name: response to hesperadin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hesperadin stimulus." [GOC:TermGenie]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0014075 ! response to amine
created_by: mah
creation_date: 2012-11-07T17:16:57Z

[Term]
id: GO:1901596
name: response to reversine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reversine stimulus." [GOC:TermGenie]
is_a: GO:0014074 ! response to purine-containing compound
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: mah
creation_date: 2012-11-07T17:17:01Z

[Term]
id: GO:1901597
name: response to carbendazim
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbendazim stimulus." [GOC:TermGenie]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: mah
creation_date: 2012-11-07T17:17:06Z

[Term]
id: GO:1901598
name: (-)-pinoresinol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (-)-pinoresinol." [GOC:TermGenie]
synonym: "(-)-pinoresinol metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009806 ! lignan metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
created_by: tb
creation_date: 2012-11-08T01:15:57Z

[Term]
id: GO:1901599
name: (-)-pinoresinol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (-)-pinoresinol." [GOC:TermGenie]
synonym: "(-)-pinoresinol anabolism" EXACT [GOC:TermGenie]
synonym: "(-)-pinoresinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "(-)-pinoresinol formation" EXACT [GOC:TermGenie]
synonym: "(-)-pinoresinol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009807 ! lignan biosynthetic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:1901598 ! (-)-pinoresinol metabolic process
created_by: tb
creation_date: 2012-11-08T01:16:05Z

[Term]
id: GO:1901600
name: strigolactone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving strigolactone." [GOC:TermGenie]
synonym: "strigolactone metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006714 ! sesquiterpenoid metabolic process
is_a: GO:1901334 ! lactone metabolic process
created_by: tb
creation_date: 2012-11-08T01:20:09Z

[Term]
id: GO:1901601
name: strigolactone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of strigolactone." [GOC:TermGenie]
synonym: "strigolactone anabolism" EXACT [GOC:TermGenie]
synonym: "strigolactone biosynthesis" EXACT [GOC:TermGenie]
synonym: "strigolactone formation" EXACT [GOC:TermGenie]
synonym: "strigolactone synthesis" EXACT [GOC:TermGenie]
is_a: GO:0016106 ! sesquiterpenoid biosynthetic process
is_a: GO:1901336 ! lactone biosynthetic process
is_a: GO:1901600 ! strigolactone metabolic process
created_by: tb
creation_date: 2012-11-08T01:20:13Z

[Term]
id: GO:1901602
name: dethiobiotin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with dethiobiotin." [GOC:TermGenie]
is_a: GO:0033218 ! amide binding
is_a: GO:0033293 ! monocarboxylic acid binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding
created_by: al
creation_date: 2012-11-08T14:09:14Z

[Term]
id: GO:1901603
name: biotin transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of biotin from one side of the membrane to the other." [GOC:TermGenie]
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:0015225 ! biotin transporter activity
is_a: GO:0042887 ! amide transmembrane transporter activity
is_a: GO:0090482 ! vitamin transmembrane transporter activity
is_a: GO:1901682 ! sulfur compound transmembrane transporter activity
created_by: al
creation_date: 2012-11-08T14:18:56Z

[Term]
id: GO:1901604
name: dethiobiotin transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of dethiobiotin from one side of the membrane to the other." [GOC:TermGenie]
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:0042887 ! amide transmembrane transporter activity
created_by: al
creation_date: 2012-11-08T14:42:53Z

[Term]
id: GO:1901605
name: alpha-amino acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an alpha-amino acid." [GOC:TermGenie]
synonym: "alpha-amino acid metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006520 ! cellular amino acid metabolic process
created_by: tb
creation_date: 2012-11-08T17:39:50Z

[Term]
id: GO:1901606
name: alpha-amino acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of an alpha-amino acid." [GOC:TermGenie]
synonym: "alpha-amino acid breakdown" EXACT [GOC:TermGenie]
synonym: "alpha-amino acid catabolism" EXACT [GOC:TermGenie]
synonym: "alpha-amino acid degradation" EXACT [GOC:TermGenie]
is_a: GO:0009063 ! cellular amino acid catabolic process
is_a: GO:1901605 ! alpha-amino acid metabolic process
created_by: tb
creation_date: 2012-11-08T17:39:54Z

[Term]
id: GO:1901607
name: alpha-amino acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an alpha-amino acid." [GOC:TermGenie]
synonym: "alpha-amino acid anabolism" EXACT [GOC:TermGenie]
synonym: "alpha-amino acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "alpha-amino acid formation" EXACT [GOC:TermGenie]
synonym: "alpha-amino acid synthesis" EXACT [GOC:TermGenie]
is_a: GO:0008652 ! cellular amino acid biosynthetic process
is_a: GO:1901605 ! alpha-amino acid metabolic process
created_by: tb
creation_date: 2012-11-08T17:39:58Z

[Term]
id: GO:1901608
name: regulation of vesicle transport along microtubule
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vesicle transport along microtubule." [GOC:TermGenie]
synonym: "regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie]
is_a: GO:1902513 ! regulation of organelle transport along microtubule
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0047496 ! vesicle transport along microtubule
relationship: regulates GO:0047496 ! vesicle transport along microtubule
created_by: hjd
creation_date: 2012-11-08T21:49:44Z

[Term]
id: GO:1901609
name: negative regulation of vesicle transport along microtubule
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vesicle transport along microtubule." [GOC:TermGenie]
synonym: "down regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie]
synonym: "down regulation of vesicle transport along microtubule" EXACT [GOC:TermGenie]
synonym: "down-regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie]
synonym: "down-regulation of vesicle transport along microtubule" EXACT [GOC:TermGenie]
synonym: "downregulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie]
synonym: "downregulation of vesicle transport along microtubule" EXACT [GOC:TermGenie]
synonym: "inhibition of microtubule-based vesicle localization" EXACT [GOC:TermGenie]
synonym: "inhibition of vesicle transport along microtubule" NARROW [GOC:TermGenie]
synonym: "negative regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie]
is_a: GO:0032387 ! negative regulation of intracellular transport
is_a: GO:0051271 ! negative regulation of cellular component movement
is_a: GO:1901608 ! regulation of vesicle transport along microtubule
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0047496 ! vesicle transport along microtubule
relationship: negatively_regulates GO:0047496 ! vesicle transport along microtubule
created_by: hjd
creation_date: 2012-11-08T21:49:48Z

[Term]
id: GO:1901610
name: positive regulation of vesicle transport along microtubule
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vesicle transport along microtubule." [GOC:TermGenie]
synonym: "activation of microtubule-based vesicle localization" EXACT [GOC:TermGenie]
synonym: "activation of vesicle transport along microtubule" NARROW [GOC:TermGenie]
synonym: "positive regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie]
synonym: "up regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie]
synonym: "up regulation of vesicle transport along microtubule" EXACT [GOC:TermGenie]
synonym: "up-regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie]
synonym: "up-regulation of vesicle transport along microtubule" EXACT [GOC:TermGenie]
synonym: "upregulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie]
synonym: "upregulation of vesicle transport along microtubule" EXACT [GOC:TermGenie]
is_a: GO:0032388 ! positive regulation of intracellular transport
is_a: GO:0051272 ! positive regulation of cellular component movement
is_a: GO:1901608 ! regulation of vesicle transport along microtubule
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0047496 ! vesicle transport along microtubule
relationship: positively_regulates GO:0047496 ! vesicle transport along microtubule
created_by: hjd
creation_date: 2012-11-08T21:49:53Z

[Term]
id: GO:1901611
name: phosphatidylglycerol binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with phosphatidylglycerol." [GOC:kmv, GOC:TermGenie]
is_a: GO:0005543 ! phospholipid binding
created_by: kmv
creation_date: 2012-11-12T21:18:24Z

[Term]
id: GO:1901612
name: cardiolipin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with cardiolipin." [GOC:kmv, GOC:TermGenie]
is_a: GO:1901611 ! phosphatidylglycerol binding
created_by: kmv
creation_date: 2012-11-12T21:19:50Z

[Term]
id: GO:1901613
name: negative regulation of terminal button organization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of terminal button organization." [GOC:TermGenie, PMID:22426000]
synonym: "down regulation of bouton organization" EXACT [GOC:TermGenie]
synonym: "down regulation of presynaptic bouton organization" EXACT [GOC:TermGenie]
synonym: "down regulation of synaptic bouton organization" EXACT [GOC:TermGenie]
synonym: "down regulation of terminal bouton organization" EXACT [GOC:TermGenie]
synonym: "down regulation of terminal button organisation" EXACT [GOC:TermGenie]
synonym: "down regulation of terminal button organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of bouton organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of presynaptic bouton organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of synaptic bouton organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of terminal bouton organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of terminal button organisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of terminal button organization" EXACT [GOC:TermGenie]
synonym: "downregulation of bouton organization" EXACT [GOC:TermGenie]
synonym: "downregulation of presynaptic bouton organization" EXACT [GOC:TermGenie]
synonym: "downregulation of synaptic bouton organization" EXACT [GOC:TermGenie]
synonym: "downregulation of terminal bouton organization" EXACT [GOC:TermGenie]
synonym: "downregulation of terminal button organisation" EXACT [GOC:TermGenie]
synonym: "downregulation of terminal button organization" EXACT [GOC:TermGenie]
synonym: "inhibition of bouton organization" NARROW [GOC:TermGenie]
synonym: "inhibition of presynaptic bouton organization" NARROW [GOC:TermGenie]
synonym: "inhibition of synaptic bouton organization" NARROW [GOC:TermGenie]
synonym: "inhibition of terminal bouton organization" NARROW [GOC:TermGenie]
synonym: "inhibition of terminal button organisation" NARROW [GOC:TermGenie]
synonym: "inhibition of terminal button organization" NARROW [GOC:TermGenie]
synonym: "negative regulation of bouton organization" EXACT [GOC:TermGenie]
synonym: "negative regulation of presynaptic bouton organization" EXACT [GOC:TermGenie]
synonym: "negative regulation of synaptic bouton organization" EXACT [GOC:TermGenie]
synonym: "negative regulation of terminal bouton organization" EXACT [GOC:TermGenie]
synonym: "negative regulation of terminal button organisation" EXACT [GOC:TermGenie]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:2000331 ! regulation of terminal button organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072553 ! terminal button organization
relationship: negatively_regulates GO:0072553 ! terminal button organization
created_by: lb
creation_date: 2012-11-13T10:40:51Z

[Term]
id: GO:1901614
name: positive regulation of terminal button organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of terminal button organization." [GOC:TermGenie, PMID:22426000]
synonym: "activation of bouton organization" NARROW [GOC:TermGenie]
synonym: "activation of presynaptic bouton organization" NARROW [GOC:TermGenie]
synonym: "activation of synaptic bouton organization" NARROW [GOC:TermGenie]
synonym: "activation of terminal bouton organization" NARROW [GOC:TermGenie]
synonym: "activation of terminal button organisation" NARROW [GOC:TermGenie]
synonym: "activation of terminal button organization" NARROW [GOC:TermGenie]
synonym: "positive regulation of bouton organization" EXACT [GOC:TermGenie]
synonym: "positive regulation of presynaptic bouton organization" EXACT [GOC:TermGenie]
synonym: "positive regulation of synaptic bouton organization" EXACT [GOC:TermGenie]
synonym: "positive regulation of terminal bouton organization" EXACT [GOC:TermGenie]
synonym: "positive regulation of terminal button organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of bouton organization" EXACT [GOC:TermGenie]
synonym: "up regulation of presynaptic bouton organization" EXACT [GOC:TermGenie]
synonym: "up regulation of synaptic bouton organization" EXACT [GOC:TermGenie]
synonym: "up regulation of terminal bouton organization" EXACT [GOC:TermGenie]
synonym: "up regulation of terminal button organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of terminal button organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of bouton organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of presynaptic bouton organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of synaptic bouton organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of terminal bouton organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of terminal button organisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of terminal button organization" EXACT [GOC:TermGenie]
synonym: "upregulation of bouton organization" EXACT [GOC:TermGenie]
synonym: "upregulation of presynaptic bouton organization" EXACT [GOC:TermGenie]
synonym: "upregulation of synaptic bouton organization" EXACT [GOC:TermGenie]
synonym: "upregulation of terminal bouton organization" EXACT [GOC:TermGenie]
synonym: "upregulation of terminal button organisation" EXACT [GOC:TermGenie]
synonym: "upregulation of terminal button organization" EXACT [GOC:TermGenie]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:2000331 ! regulation of terminal button organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072553 ! terminal button organization
relationship: positively_regulates GO:0072553 ! terminal button organization
created_by: lb
creation_date: 2012-11-13T10:40:58Z

[Term]
id: GO:1901615
name: organic hydroxy compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving organic hydroxy compound." [GOC:pr, GOC:TermGenie]
synonym: "organic hydroxy compound metabolism" EXACT [GOC:TermGenie]
is_a: GO:0071704 ! organic substance metabolic process
created_by: pr
creation_date: 2012-11-13T12:54:27Z

[Term]
id: GO:1901616
name: organic hydroxy compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of organic hydroxy compound." [GOC:pr, GOC:TermGenie]
synonym: "organic hydroxy compound breakdown" EXACT [GOC:TermGenie]
synonym: "organic hydroxy compound catabolism" EXACT [GOC:TermGenie]
synonym: "organic hydroxy compound degradation" EXACT [GOC:TermGenie]
is_a: GO:1901575 ! organic substance catabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process
created_by: pr
creation_date: 2012-11-13T12:54:31Z

[Term]
id: GO:1901617
name: organic hydroxy compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of organic hydroxy compound." [GOC:pr, GOC:TermGenie]
synonym: "organic hydroxy compound anabolism" EXACT [GOC:TermGenie]
synonym: "organic hydroxy compound biosynthesis" EXACT [GOC:TermGenie]
synonym: "organic hydroxy compound formation" EXACT [GOC:TermGenie]
synonym: "organic hydroxy compound synthesis" EXACT [GOC:TermGenie]
is_a: GO:1901576 ! organic substance biosynthetic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process
created_by: pr
creation_date: 2012-11-13T12:54:36Z

[Term]
id: GO:1901618
name: organic hydroxy compound transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of organic hydroxy compound from one side of the membrane to the other." [GOC:pr, GOC:TermGenie]
is_a: GO:0022857 ! transmembrane transporter activity
created_by: pr
creation_date: 2012-11-13T12:59:01Z

[Term]
id: GO:1901619
name: tRNA methylation in response to nitrogen starvation
namespace: biological_process
def: "The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule as a result of deprivation of nitrogen." [GOC:TermGenie, PMID:23074192]
is_a: GO:0006995 ! cellular response to nitrogen starvation
is_a: GO:0030488 ! tRNA methylation
is_a: GO:0044710 ! single-organism metabolic process
created_by: al
creation_date: 2012-11-13T14:36:00Z

[Term]
id: GO:1901620
name: regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of smoothened signaling pathway involved in dorsal/ventral neural tube patterning." [GOC:TermGenie]
synonym: "regulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "regulation of hh signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "regulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
is_a: GO:0008589 ! regulation of smoothened signaling pathway
is_a: GO:0045995 ! regulation of embryonic development
is_a: GO:0051960 ! regulation of nervous system development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060831 ! smoothened signaling pathway involved in dorsal/ventral neural tube patterning
relationship: regulates GO:0060831 ! smoothened signaling pathway involved in dorsal/ventral neural tube patterning
created_by: krc
creation_date: 2012-11-13T20:11:57Z

[Term]
id: GO:1901621
name: negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of smoothened signaling pathway involved in dorsal/ventral neural tube patterning." [GOC:TermGenie]
synonym: "down regulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "down regulation of hh signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "down regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "down regulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "down-regulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "down-regulation of hh signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "down-regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "down-regulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "downregulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "downregulation of hh signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "downregulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "downregulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "inhibition of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning" NARROW [GOC:TermGenie]
synonym: "inhibition of hh signaling pathway involved in dorsal/ventral neural tube patterning" NARROW [GOC:TermGenie]
synonym: "inhibition of smoothened signaling pathway involved in dorsal/ventral neural tube patterning" NARROW [GOC:TermGenie]
synonym: "inhibition of smoothened signalling pathway involved in dorsal/ventral neural tube patterning" NARROW [GOC:TermGenie]
synonym: "negative regulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "negative regulation of hh signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "negative regulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
is_a: GO:0045879 ! negative regulation of smoothened signaling pathway
is_a: GO:0045992 ! negative regulation of embryonic development
is_a: GO:0051961 ! negative regulation of nervous system development
is_a: GO:1901620 ! regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060831 ! smoothened signaling pathway involved in dorsal/ventral neural tube patterning
relationship: negatively_regulates GO:0060831 ! smoothened signaling pathway involved in dorsal/ventral neural tube patterning
created_by: krc
creation_date: 2012-11-13T20:12:01Z

[Term]
id: GO:1901622
name: positive regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of smoothened signaling pathway involved in dorsal/ventral neural tube patterning." [GOC:TermGenie]
synonym: "activation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning" NARROW [GOC:TermGenie]
synonym: "activation of hh signaling pathway involved in dorsal/ventral neural tube patterning" NARROW [GOC:TermGenie]
synonym: "activation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning" NARROW [GOC:TermGenie]
synonym: "activation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning" NARROW [GOC:TermGenie]
synonym: "positive regulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "positive regulation of hh signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "positive regulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "up regulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "up regulation of hh signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "up regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "up regulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "up-regulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "up-regulation of hh signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "up-regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "up-regulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "upregulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "upregulation of hh signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "upregulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
synonym: "upregulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie]
is_a: GO:0040019 ! positive regulation of embryonic development
is_a: GO:0045880 ! positive regulation of smoothened signaling pathway
is_a: GO:0051962 ! positive regulation of nervous system development
is_a: GO:1901620 ! regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060831 ! smoothened signaling pathway involved in dorsal/ventral neural tube patterning
relationship: positively_regulates GO:0060831 ! smoothened signaling pathway involved in dorsal/ventral neural tube patterning
created_by: krc
creation_date: 2012-11-13T20:12:06Z

[Term]
id: GO:1901623
name: regulation of lymphocyte chemotaxis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lymphocyte chemotaxis." [GOC:TermGenie]
is_a: GO:0002688 ! regulation of leukocyte chemotaxis
is_a: GO:2000401 ! regulation of lymphocyte migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048247 ! lymphocyte chemotaxis
relationship: regulates GO:0048247 ! lymphocyte chemotaxis
created_by: tb
creation_date: 2012-11-13T23:03:23Z

[Term]
id: GO:1901624
name: negative regulation of lymphocyte chemotaxis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte chemotaxis." [GOC:TermGenie]
synonym: "down regulation of lymphocyte chemotaxis" EXACT [GOC:TermGenie]
synonym: "down-regulation of lymphocyte chemotaxis" EXACT [GOC:TermGenie]
synonym: "downregulation of lymphocyte chemotaxis" EXACT [GOC:TermGenie]
synonym: "inhibition of lymphocyte chemotaxis" NARROW [GOC:TermGenie]
is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis
is_a: GO:1901623 ! regulation of lymphocyte chemotaxis
is_a: GO:2000402 ! negative regulation of lymphocyte migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048247 ! lymphocyte chemotaxis
relationship: negatively_regulates GO:0048247 ! lymphocyte chemotaxis
created_by: tb
creation_date: 2012-11-13T23:03:28Z

[Term]
id: GO:1901625
name: cellular response to ergosterol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ergosterol stimulus." [GOC:TermGenie]
is_a: GO:0036315 ! cellular response to sterol
created_by: dph
creation_date: 2012-11-14T13:53:51Z

[Term]
id: GO:1901626
name: regulation of postsynaptic membrane organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of postsynaptic membrane organization." [GOC:TermGenie, PubMed:22426000]
synonym: "regulation of post-synaptic membrane organization" EXACT []
synonym: "regulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie]
is_a: GO:0050807 ! regulation of synapse organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001941 ! postsynaptic membrane organization
relationship: regulates GO:0001941 ! postsynaptic membrane organization
created_by: ans
creation_date: 2012-11-15T11:40:15Z

[Term]
id: GO:1901627
name: negative regulation of postsynaptic membrane organization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of postsynaptic membrane organization." [GOC:TermGenie, PubMed:22426000]
synonym: "down regulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie]
synonym: "down regulation of postsynaptic membrane organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of postsynaptic membrane organization" EXACT [GOC:TermGenie]
synonym: "downregulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie]
synonym: "downregulation of postsynaptic membrane organization" EXACT [GOC:TermGenie]
synonym: "inhibition of postsynaptic membrane organisation" NARROW [GOC:TermGenie]
synonym: "inhibition of postsynaptic membrane organization" NARROW [GOC:TermGenie]
synonym: "negative regulation of post-synaptic membrane organization" EXACT []
synonym: "negative regulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1901626 ! regulation of postsynaptic membrane organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001941 ! postsynaptic membrane organization
relationship: negatively_regulates GO:0001941 ! postsynaptic membrane organization
created_by: ans
creation_date: 2012-11-15T11:40:20Z

[Term]
id: GO:1901628
name: positive regulation of postsynaptic membrane organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of postsynaptic membrane organization." [GOC:TermGenie, PubMed:22426000]
synonym: "activation of postsynaptic membrane organisation" NARROW [GOC:TermGenie]
synonym: "activation of postsynaptic membrane organization" NARROW [GOC:TermGenie]
synonym: "positive regulation of post-synaptic membrane organization" EXACT []
synonym: "positive regulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of postsynaptic membrane organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of postsynaptic membrane organization" EXACT [GOC:TermGenie]
synonym: "upregulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie]
synonym: "upregulation of postsynaptic membrane organization" EXACT [GOC:TermGenie]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1901626 ! regulation of postsynaptic membrane organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001941 ! postsynaptic membrane organization
relationship: positively_regulates GO:0001941 ! postsynaptic membrane organization
created_by: ans
creation_date: 2012-11-15T11:40:24Z

[Term]
id: GO:1901629
name: regulation of presynaptic membrane organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of presynaptic membrane organization." [GOC:TermGenie, PubMed:22426000]
synonym: "regulation of pre-synaptic membrane organization" EXACT []
synonym: "regulation of presynaptic membrane organisation" EXACT [GOC:TermGenie]
is_a: GO:0050807 ! regulation of synapse organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097090 ! presynaptic membrane organization
relationship: regulates GO:0097090 ! presynaptic membrane organization
created_by: ans
creation_date: 2012-11-15T11:40:32Z

[Term]
id: GO:1901630
name: negative regulation of presynaptic membrane organization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of presynaptic membrane organization." [GOC:TermGenie, PubMed:22426000]
synonym: "down regulation of presynaptic membrane organisation" EXACT [GOC:TermGenie]
synonym: "down regulation of presynaptic membrane organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of presynaptic membrane organisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of presynaptic membrane organization" EXACT [GOC:TermGenie]
synonym: "downregulation of presynaptic membrane organisation" EXACT [GOC:TermGenie]
synonym: "downregulation of presynaptic membrane organization" EXACT [GOC:TermGenie]
synonym: "inhibition of presynaptic membrane organisation" NARROW [GOC:TermGenie]
synonym: "inhibition of presynaptic membrane organization" NARROW [GOC:TermGenie]
synonym: "negative regulation of pre-synaptic membrane organization" EXACT []
synonym: "negative regulation of presynaptic membrane organisation" EXACT [GOC:TermGenie]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1901629 ! regulation of presynaptic membrane organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097090 ! presynaptic membrane organization
relationship: negatively_regulates GO:0097090 ! presynaptic membrane organization
created_by: ans
creation_date: 2012-11-15T11:40:36Z

[Term]
id: GO:1901631
name: positive regulation of presynaptic membrane organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of presynaptic membrane organization." [GOC:TermGenie, PubMed:22426000]
synonym: "activation of presynaptic membrane organisation" NARROW [GOC:TermGenie]
synonym: "activation of presynaptic membrane organization" NARROW [GOC:TermGenie]
synonym: "positive regulation of pre-synaptic membrane organization" EXACT []
synonym: "positive regulation of presynaptic membrane organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of presynaptic membrane organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of presynaptic membrane organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of presynaptic membrane organisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of presynaptic membrane organization" EXACT [GOC:TermGenie]
synonym: "upregulation of presynaptic membrane organisation" EXACT [GOC:TermGenie]
synonym: "upregulation of presynaptic membrane organization" EXACT [GOC:TermGenie]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1901629 ! regulation of presynaptic membrane organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097090 ! presynaptic membrane organization
relationship: positively_regulates GO:0097090 ! presynaptic membrane organization
created_by: ans
creation_date: 2012-11-15T11:40:40Z

[Term]
id: GO:1901632
name: regulation of synaptic vesicle membrane organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synaptic vesicle membrane organization." [GOC:TermGenie, PubMed:22426000]
synonym: "regulation of SLMV biogenesis" NARROW [GOC:TermGenie]
synonym: "regulation of synaptic vesicle membrane organisation" EXACT [GOC:TermGenie]
synonym: "regulation of synaptic vesicle membrane organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048499 ! synaptic vesicle membrane organization
relationship: regulates GO:0048499 ! synaptic vesicle membrane organization
created_by: ans
creation_date: 2012-11-15T11:40:48Z

[Term]
id: GO:1901633
name: negative regulation of synaptic vesicle membrane organization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle membrane organization." [GOC:TermGenie, PubMed:22426000]
synonym: "down regulation of SLMV biogenesis" NARROW [GOC:TermGenie]
synonym: "down regulation of synaptic vesicle membrane organisation" EXACT [GOC:TermGenie]
synonym: "down regulation of synaptic vesicle membrane organization" EXACT [GOC:TermGenie]
synonym: "down regulation of synaptic vesicle membrane organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of SLMV biogenesis" NARROW [GOC:TermGenie]
synonym: "down-regulation of synaptic vesicle membrane organisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of synaptic vesicle membrane organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of synaptic vesicle membrane organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "downregulation of SLMV biogenesis" NARROW [GOC:TermGenie]
synonym: "downregulation of synaptic vesicle membrane organisation" EXACT [GOC:TermGenie]
synonym: "downregulation of synaptic vesicle membrane organization" EXACT [GOC:TermGenie]
synonym: "downregulation of synaptic vesicle membrane organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "inhibition of SLMV biogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of synaptic vesicle membrane organisation" NARROW [GOC:TermGenie]
synonym: "inhibition of synaptic vesicle membrane organization" NARROW [GOC:TermGenie]
synonym: "inhibition of synaptic vesicle membrane organization and biogenesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of SLMV biogenesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of synaptic vesicle membrane organisation" EXACT [GOC:TermGenie]
synonym: "negative regulation of synaptic vesicle membrane organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1901632 ! regulation of synaptic vesicle membrane organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048499 ! synaptic vesicle membrane organization
relationship: negatively_regulates GO:0048499 ! synaptic vesicle membrane organization
created_by: ans
creation_date: 2012-11-15T11:40:55Z

[Term]
id: GO:1901634
name: positive regulation of synaptic vesicle membrane organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of synaptic vesicle membrane organization." [GOC:TermGenie, PubMed:22426000]
synonym: "activation of SLMV biogenesis" NARROW [GOC:TermGenie]
synonym: "activation of synaptic vesicle membrane organisation" NARROW [GOC:TermGenie]
synonym: "activation of synaptic vesicle membrane organization" NARROW [GOC:TermGenie]
synonym: "activation of synaptic vesicle membrane organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of SLMV biogenesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of synaptic vesicle membrane organisation" EXACT [GOC:TermGenie]
synonym: "positive regulation of synaptic vesicle membrane organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "up regulation of SLMV biogenesis" NARROW [GOC:TermGenie]
synonym: "up regulation of synaptic vesicle membrane organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of synaptic vesicle membrane organization" EXACT [GOC:TermGenie]
synonym: "up regulation of synaptic vesicle membrane organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of SLMV biogenesis" NARROW [GOC:TermGenie]
synonym: "up-regulation of synaptic vesicle membrane organisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of synaptic vesicle membrane organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of synaptic vesicle membrane organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "upregulation of SLMV biogenesis" NARROW [GOC:TermGenie]
synonym: "upregulation of synaptic vesicle membrane organisation" EXACT [GOC:TermGenie]
synonym: "upregulation of synaptic vesicle membrane organization" EXACT [GOC:TermGenie]
synonym: "upregulation of synaptic vesicle membrane organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1901632 ! regulation of synaptic vesicle membrane organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048499 ! synaptic vesicle membrane organization
relationship: positively_regulates GO:0048499 ! synaptic vesicle membrane organization
created_by: ans
creation_date: 2012-11-15T11:40:59Z

[Term]
id: GO:1901635
name: obsolete regulation of maintenance of presynaptic active zone structure
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of maintenance of presynaptic active zone structure." [GOC:TermGenie, PubMed:22426000]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "regulation of maintenance of presynaptic active zone structure" EXACT []
is_obsolete: true
created_by: ans
creation_date: 2012-11-15T14:17:03Z

[Term]
id: GO:1901636
name: obsolete negative regulation of maintenance of presynaptic active zone structure
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of presynaptic active zone structure." [GOC:TermGenie, PubMed:22426000]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "down regulation of maintenance of presynaptic active zone structure" EXACT [GOC:TermGenie]
synonym: "down-regulation of maintenance of presynaptic active zone structure" EXACT [GOC:TermGenie]
synonym: "downregulation of maintenance of presynaptic active zone structure" EXACT [GOC:TermGenie]
synonym: "inhibition of maintenance of presynaptic active zone structure" NARROW [GOC:TermGenie]
synonym: "negative regulation of maintenance of presynaptic active zone structure" EXACT []
is_obsolete: true
created_by: ans
creation_date: 2012-11-15T14:17:07Z

[Term]
id: GO:1901637
name: obsolete positive regulation of maintenance of presynaptic active zone structure
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of maintenance of presynaptic active zone structure." [GOC:TermGenie, PubMed:22426000]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "activation of maintenance of presynaptic active zone structure" NARROW [GOC:TermGenie]
synonym: "positive regulation of maintenance of presynaptic active zone structure" EXACT []
synonym: "up regulation of maintenance of presynaptic active zone structure" EXACT [GOC:TermGenie]
synonym: "up-regulation of maintenance of presynaptic active zone structure" EXACT [GOC:TermGenie]
synonym: "upregulation of maintenance of presynaptic active zone structure" EXACT [GOC:TermGenie]
is_obsolete: true
created_by: ans
creation_date: 2012-11-15T14:17:16Z

[Term]
id: GO:1901638
name: obsolete copper ion import into ascospore-type prospore
namespace: biological_process
def: "OBSOLETE. Any copper ion import that takes place in ascospore-type prospore." [GOC:TermGenie]
comment: https://sourceforge.net/tracker/index.php?func=detail&aid=3510080&group_id=36855&atid=440764
synonym: "copper ion import into ascospore-type prospore" EXACT []
synonym: "copper ion uptake in ascospore-type prospore" EXACT [GOC:TermGenie]
is_obsolete: true
created_by: al
creation_date: 2012-11-15T15:44:04Z

[Term]
id: GO:1901639
name: XDP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of XDP." [GOC:TermGenie]
synonym: "XDP breakdown" EXACT [GOC:TermGenie]
synonym: "XDP catabolism" EXACT [GOC:TermGenie]
synonym: "XDP degradation" EXACT [GOC:TermGenie]
is_a: GO:0009154 ! purine ribonucleotide catabolic process
is_a: GO:0009181 ! purine ribonucleoside diphosphate catabolic process
created_by: tb
creation_date: 2012-11-15T22:56:26Z

[Term]
id: GO:1901640
name: XTP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with XTP." [GOC:TermGenie]
is_a: GO:0032555 ! purine ribonucleotide binding
is_a: GO:0035639 ! purine ribonucleoside triphosphate binding
created_by: tb
creation_date: 2012-11-15T22:56:35Z

[Term]
id: GO:1901641
name: ITP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with ITP." [GOC:TermGenie]
is_a: GO:0032555 ! purine ribonucleotide binding
is_a: GO:0035639 ! purine ribonucleoside triphosphate binding
created_by: tb
creation_date: 2012-11-15T22:56:39Z

[Term]
id: GO:1901642
name: nucleoside transmembrane transport
namespace: biological_process
def: "The directed movement of nucleoside across a membrane." [GOC:pr, GOC:TermGenie]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "nucleoside membrane transport" EXACT []
is_a: GO:0015858 ! nucleoside transport
is_a: GO:0055085 ! transmembrane transport
created_by: pr
creation_date: 2012-11-16T13:32:01Z

[Term]
id: GO:1901643
name: regulation of tRNA methylation in response to nitrogen starvation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tRNA methylation in response to nitrogen starvation." [GOC:TermGenie]
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0032107 ! regulation of response to nutrient levels
is_a: GO:0080135 ! regulation of cellular response to stress
is_a: GO:2000235 ! regulation of tRNA processing
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1901619 ! tRNA methylation in response to nitrogen starvation
relationship: regulates GO:1901619 ! tRNA methylation in response to nitrogen starvation
created_by: al
creation_date: 2012-11-16T14:44:08Z

[Term]
id: GO:1901644
name: positive regulation of tRNA methylation in response to nitrogen starvation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tRNA methylation in response to nitrogen starvation." [GOC:TermGenie]
synonym: "activation of tRNA methylation in response to nitrogen starvation" NARROW [GOC:TermGenie]
synonym: "up regulation of tRNA methylation in response to nitrogen starvation" EXACT [GOC:TermGenie]
synonym: "up-regulation of tRNA methylation in response to nitrogen starvation" EXACT [GOC:TermGenie]
synonym: "upregulation of tRNA methylation in response to nitrogen starvation" EXACT [GOC:TermGenie]
is_a: GO:0010647 ! positive regulation of cell communication
is_a: GO:0032109 ! positive regulation of response to nutrient levels
is_a: GO:1901643 ! regulation of tRNA methylation in response to nitrogen starvation
is_a: GO:2000237 ! positive regulation of tRNA processing
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1901619 ! tRNA methylation in response to nitrogen starvation
relationship: positively_regulates GO:1901619 ! tRNA methylation in response to nitrogen starvation
created_by: al
creation_date: 2012-11-16T14:44:12Z

[Term]
id: GO:1901645
name: regulation of synoviocyte proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synoviocyte proliferation." [GOC:TermGenie]
is_a: GO:0042127 ! regulation of cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002941 ! synoviocyte proliferation
relationship: regulates GO:0002941 ! synoviocyte proliferation
created_by: hjd
creation_date: 2012-11-16T20:16:23Z

[Term]
id: GO:1901646
name: negative regulation of synoviocyte proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of synoviocyte proliferation." [GOC:TermGenie]
synonym: "down regulation of synoviocyte proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of synoviocyte proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of synoviocyte proliferation" EXACT [GOC:TermGenie]
synonym: "inhibition of synoviocyte proliferation" NARROW [GOC:TermGenie]
is_a: GO:0008285 ! negative regulation of cell proliferation
is_a: GO:1901645 ! regulation of synoviocyte proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002941 ! synoviocyte proliferation
relationship: negatively_regulates GO:0002941 ! synoviocyte proliferation
created_by: hjd
creation_date: 2012-11-16T20:16:27Z

[Term]
id: GO:1901647
name: positive regulation of synoviocyte proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of synoviocyte proliferation." [GOC:TermGenie]
synonym: "activation of synoviocyte proliferation" NARROW [GOC:TermGenie]
synonym: "up regulation of synoviocyte proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of synoviocyte proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of synoviocyte proliferation" EXACT [GOC:TermGenie]
is_a: GO:0008284 ! positive regulation of cell proliferation
is_a: GO:1901645 ! regulation of synoviocyte proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002941 ! synoviocyte proliferation
relationship: positively_regulates GO:0002941 ! synoviocyte proliferation
created_by: hjd
creation_date: 2012-11-16T20:16:32Z

[Term]
id: GO:1901648
name: regulation of actomyosin contractile ring localization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of actomyosin contractile ring localization." [GOC:TermGenie]
synonym: "regulation of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:TermGenie]
synonym: "regulation of contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:TermGenie]
is_a: GO:0032954 ! regulation of cytokinetic process
is_a: GO:0060341 ! regulation of cellular localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032187 ! actomyosin contractile ring localization
relationship: regulates GO:0032187 ! actomyosin contractile ring localization
created_by: vw
creation_date: 2012-11-19T13:42:45Z

[Term]
id: GO:1901649
name: negative regulation of actomyosin contractile ring localization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of actomyosin contractile ring localization." [GOC:TermGenie]
synonym: "down regulation of actomyosin contractile ring localization" EXACT [GOC:TermGenie]
synonym: "down regulation of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:TermGenie]
synonym: "down regulation of contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of actomyosin contractile ring localization" EXACT [GOC:TermGenie]
synonym: "down-regulation of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:TermGenie]
synonym: "downregulation of actomyosin contractile ring localization" EXACT [GOC:TermGenie]
synonym: "downregulation of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:TermGenie]
synonym: "downregulation of contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:TermGenie]
synonym: "inhibition of actomyosin contractile ring localization" NARROW [GOC:TermGenie]
synonym: "inhibition of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:TermGenie]
synonym: "inhibition of contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:TermGenie]
is_a: GO:0032466 ! negative regulation of cytokinesis
is_a: GO:1901648 ! regulation of actomyosin contractile ring localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032187 ! actomyosin contractile ring localization
relationship: negatively_regulates GO:0032187 ! actomyosin contractile ring localization
created_by: vw
creation_date: 2012-11-19T13:42:49Z

[Term]
id: GO:1901650
name: positive regulation of actomyosin contractile ring localization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of actomyosin contractile ring localization." [GOC:TermGenie]
synonym: "activation of actomyosin contractile ring localization" NARROW [GOC:TermGenie]
synonym: "activation of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:TermGenie]
synonym: "activation of contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:TermGenie]
synonym: "up regulation of actomyosin contractile ring localization" EXACT [GOC:TermGenie]
synonym: "up regulation of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:TermGenie]
synonym: "up regulation of contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of actomyosin contractile ring localization" EXACT [GOC:TermGenie]
synonym: "up-regulation of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:TermGenie]
synonym: "upregulation of actomyosin contractile ring localization" EXACT [GOC:TermGenie]
synonym: "upregulation of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:TermGenie]
synonym: "upregulation of contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:TermGenie]
is_a: GO:0032467 ! positive regulation of cytokinesis
is_a: GO:1901648 ! regulation of actomyosin contractile ring localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032187 ! actomyosin contractile ring localization
relationship: positively_regulates GO:0032187 ! actomyosin contractile ring localization
created_by: vw
creation_date: 2012-11-19T13:42:54Z

[Term]
id: GO:1901651
name: regulation of mitotic chromosome decondensation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitotic chromosome decondensation." [GOC:TermGenie]
is_a: GO:0033047 ! regulation of mitotic sister chromatid segregation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007083 ! mitotic chromosome decondensation
relationship: regulates GO:0007083 ! mitotic chromosome decondensation
created_by: dph
creation_date: 2012-11-19T14:13:58Z

[Term]
id: GO:1901652
name: response to peptide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus." [GOC:pr, GOC:TermGenie]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: pr
creation_date: 2012-11-20T09:45:15Z

[Term]
id: GO:1901653
name: cellular response to peptide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus." [GOC:pr, GOC:TermGenie]
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:1901652 ! response to peptide
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: pr
creation_date: 2012-11-20T09:45:19Z

[Term]
id: GO:1901654
name: response to ketone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketone stimulus." [GOC:pr, GOC:TermGenie]
is_a: GO:0010033 ! response to organic substance
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: pr
creation_date: 2012-11-20T10:55:47Z

[Term]
id: GO:1901655
name: cellular response to ketone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketone stimulus." [GOC:pr, GOC:TermGenie]
is_a: GO:1901654 ! response to ketone
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: pr
creation_date: 2012-11-20T10:55:51Z

[Term]
id: GO:1901656
name: glycoside transport
namespace: biological_process
def: "The directed movement of a glycoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:pr, GOC:TermGenie]
is_a: GO:1901264 ! carbohydrate derivative transport
created_by: pr
creation_date: 2012-11-20T11:59:16Z

[Term]
id: GO:1901657
name: glycosyl compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycosyl compound." [GOC:pr, GOC:TermGenie]
synonym: "glycosyl compound metabolism" EXACT [GOC:TermGenie]
is_a: GO:0044710 ! single-organism metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process
created_by: pr
creation_date: 2012-11-20T14:24:07Z

[Term]
id: GO:1901658
name: glycosyl compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycosyl compound." [GOC:pr, GOC:TermGenie]
synonym: "glycosyl compound breakdown" EXACT [GOC:TermGenie]
synonym: "glycosyl compound catabolism" EXACT [GOC:TermGenie]
synonym: "glycosyl compound degradation" EXACT [GOC:TermGenie]
is_a: GO:0044712 ! single-organism catabolic process
is_a: GO:1901136 ! carbohydrate derivative catabolic process
is_a: GO:1901657 ! glycosyl compound metabolic process
created_by: pr
creation_date: 2012-11-20T14:24:11Z

[Term]
id: GO:1901659
name: glycosyl compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycosyl compound." [GOC:pr, GOC:TermGenie]
synonym: "glycosyl compound anabolism" EXACT [GOC:TermGenie]
synonym: "glycosyl compound biosynthesis" EXACT [GOC:TermGenie]
synonym: "glycosyl compound formation" EXACT [GOC:TermGenie]
synonym: "glycosyl compound synthesis" EXACT [GOC:TermGenie]
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process
is_a: GO:1901657 ! glycosyl compound metabolic process
created_by: pr
creation_date: 2012-11-20T14:24:19Z

[Term]
id: GO:1901660
name: calcium ion export
namespace: biological_process
def: "The directed movement of calcium ion out of a cell or organelle." [GOC:TermGenie]
is_a: GO:0006816 ! calcium ion transport
created_by: jl
creation_date: 2012-11-20T14:33:07Z

[Term]
id: GO:1901661
name: quinone metabolic process
namespace: biological_process
alt_id: GO:0042375
def: "The chemical reactions and pathways involving quinone." [GOC:go_curators, GOC:pr, GOC:TermGenie]
subset: gosubset_prok
synonym: "quinone cofactor metabolic process" RELATED []
synonym: "quinone cofactor metabolism" RELATED []
synonym: "quinone metabolism" EXACT [GOC:TermGenie]
is_a: GO:0042180 ! cellular ketone metabolic process
is_a: GO:0051186 ! cofactor metabolic process
created_by: pr
creation_date: 2012-11-20T14:44:39Z

[Term]
id: GO:1901662
name: quinone catabolic process
namespace: biological_process
alt_id: GO:0042378
def: "The chemical reactions and pathways resulting in the breakdown of quinone." [GOC:go_curators, GOC:pr, GOC:TermGenie]
subset: gosubset_prok
synonym: "quinone breakdown" EXACT [GOC:TermGenie]
synonym: "quinone catabolism" EXACT [GOC:TermGenie]
synonym: "quinone cofactor breakdown" RELATED []
synonym: "quinone cofactor catabolic process" RELATED []
synonym: "quinone cofactor catabolism" RELATED []
synonym: "quinone cofactor degradation" RELATED []
synonym: "quinone degradation" EXACT [GOC:TermGenie]
is_a: GO:0009109 ! coenzyme catabolic process
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:1901661 ! quinone metabolic process
created_by: pr
creation_date: 2012-11-20T14:44:44Z

[Term]
id: GO:1901663
name: quinone biosynthetic process
namespace: biological_process
alt_id: GO:0045426
def: "The chemical reactions and pathways resulting in the formation of quinone." [GOC:mb, GOC:pr, GOC:TermGenie]
subset: gosubset_prok
synonym: "quinone anabolism" EXACT [GOC:TermGenie]
synonym: "quinone biosynthesis" EXACT [GOC:TermGenie]
synonym: "quinone cofactor anabolism" RELATED []
synonym: "quinone cofactor biosynthesis" RELATED []
synonym: "quinone cofactor biosynthetic process" RELATED []
synonym: "quinone cofactor formation" RELATED []
synonym: "quinone cofactor synthesis" RELATED []
synonym: "quinone formation" EXACT [GOC:TermGenie]
synonym: "quinone synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:1901661 ! quinone metabolic process
created_by: pr
creation_date: 2012-11-20T14:44:48Z

[Term]
id: GO:1901664
name: regulation of NAD+ ADP-ribosyltransferase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of NAD+ ADP-ribosyltransferase activity." [GOC:BHF, GOC:TermGenie]
synonym: "regulation of ADP-ribosyltransferase (polymerizing) activity" EXACT [GOC:TermGenie]
synonym: "regulation of NAD ADP-ribosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of poly(adenosine diphosphate ribose) polymerase activity" EXACT [GOC:TermGenie]
synonym: "regulation of poly(ADP-ribose) synthase activity" EXACT [GOC:TermGenie]
synonym: "regulation of poly(ADP-ribose) synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of poly(ADP-ribose)polymerase activity" EXACT [GOC:TermGenie]
is_a: GO:0051338 ! regulation of transferase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003950 ! NAD+ ADP-ribosyltransferase activity
relationship: regulates GO:0003950 ! NAD+ ADP-ribosyltransferase activity
created_by: vk
creation_date: 2012-11-20T18:50:07Z

[Term]
id: GO:1901665
name: negative regulation of NAD+ ADP-ribosyltransferase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of NAD+ ADP-ribosyltransferase activity." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of ADP-ribosyltransferase (polymerizing) activity" EXACT [GOC:TermGenie]
synonym: "down regulation of NAD ADP-ribosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of NAD+ ADP-ribosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of poly(adenosine diphosphate ribose) polymerase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of poly(ADP-ribose) synthase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of poly(ADP-ribose) synthetase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of poly(ADP-ribose)polymerase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of ADP-ribosyltransferase (polymerizing) activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of NAD ADP-ribosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of NAD+ ADP-ribosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of poly(adenosine diphosphate ribose) polymerase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of poly(ADP-ribose) synthase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of poly(ADP-ribose) synthetase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of poly(ADP-ribose)polymerase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of ADP-ribosyltransferase (polymerizing) activity" EXACT [GOC:TermGenie]
synonym: "downregulation of NAD ADP-ribosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of NAD+ ADP-ribosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of poly(adenosine diphosphate ribose) polymerase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of poly(ADP-ribose) synthase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of poly(ADP-ribose) synthetase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of poly(ADP-ribose)polymerase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of ADP-ribosyltransferase (polymerizing) activity" EXACT [GOC:TermGenie]
synonym: "inhibition of NAD ADP-ribosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of NAD+ ADP-ribosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of poly(adenosine diphosphate ribose) polymerase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of poly(ADP-ribose) synthase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of poly(ADP-ribose) synthetase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of poly(ADP-ribose)polymerase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of ADP-ribosyltransferase (polymerizing) activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of NAD ADP-ribosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of poly(adenosine diphosphate ribose) polymerase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of poly(ADP-ribose) synthase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of poly(ADP-ribose) synthetase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of poly(ADP-ribose)polymerase activity" EXACT [GOC:TermGenie]
is_a: GO:0051348 ! negative regulation of transferase activity
is_a: GO:1901664 ! regulation of NAD+ ADP-ribosyltransferase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003950 ! NAD+ ADP-ribosyltransferase activity
relationship: negatively_regulates GO:0003950 ! NAD+ ADP-ribosyltransferase activity
created_by: vk
creation_date: 2012-11-20T18:50:15Z

[Term]
id: GO:1901666
name: positive regulation of NAD+ ADP-ribosyltransferase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of NAD+ ADP-ribosyltransferase activity." [GOC:BHF, GOC:TermGenie]
synonym: "activation of ADP-ribosyltransferase (polymerizing) activity" EXACT [GOC:TermGenie]
synonym: "activation of NAD ADP-ribosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "activation of NAD+ ADP-ribosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" EXACT [GOC:TermGenie]
synonym: "activation of poly(adenosine diphosphate ribose) polymerase activity" EXACT [GOC:TermGenie]
synonym: "activation of poly(ADP-ribose) synthase activity" EXACT [GOC:TermGenie]
synonym: "activation of poly(ADP-ribose) synthetase activity" EXACT [GOC:TermGenie]
synonym: "activation of poly(ADP-ribose)polymerase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of ADP-ribosyltransferase (polymerizing) activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of NAD ADP-ribosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of poly(adenosine diphosphate ribose) polymerase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of poly(ADP-ribose) synthase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of poly(ADP-ribose) synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of poly(ADP-ribose)polymerase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of ADP-ribosyltransferase (polymerizing) activity" EXACT [GOC:TermGenie]
synonym: "up regulation of NAD ADP-ribosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of NAD+ ADP-ribosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of poly(adenosine diphosphate ribose) polymerase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of poly(ADP-ribose) synthase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of poly(ADP-ribose) synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of poly(ADP-ribose)polymerase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of ADP-ribosyltransferase (polymerizing) activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of NAD ADP-ribosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of NAD+ ADP-ribosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of poly(adenosine diphosphate ribose) polymerase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of poly(ADP-ribose) synthase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of poly(ADP-ribose) synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of poly(ADP-ribose)polymerase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of ADP-ribosyltransferase (polymerizing) activity" EXACT [GOC:TermGenie]
synonym: "upregulation of NAD ADP-ribosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of NAD+ ADP-ribosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of poly(adenosine diphosphate ribose) polymerase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of poly(ADP-ribose) synthase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of poly(ADP-ribose) synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of poly(ADP-ribose)polymerase activity" EXACT [GOC:TermGenie]
is_a: GO:0051347 ! positive regulation of transferase activity
is_a: GO:1901664 ! regulation of NAD+ ADP-ribosyltransferase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003950 ! NAD+ ADP-ribosyltransferase activity
relationship: positively_regulates GO:0003950 ! NAD+ ADP-ribosyltransferase activity
created_by: vk
creation_date: 2012-11-20T18:50:20Z

[Term]
id: GO:1901667
name: negative regulation of skeletal muscle satellite cell activation involved in skeletal muscle regeneration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of satellite cell activation involved in skeletal muscle regeneration." [GOC:dph, GOC:TermGenie, PMID:21272575]
synonym: "down regulation of satellite cell activation involved in skeletal muscle regeneration" EXACT [GOC:TermGenie]
synonym: "down-regulation of satellite cell activation involved in skeletal muscle regeneration" EXACT [GOC:TermGenie]
synonym: "downregulation of satellite cell activation involved in skeletal muscle regeneration" EXACT [GOC:TermGenie]
synonym: "inhibition of satellite cell activation involved in skeletal muscle regeneration" NARROW [GOC:TermGenie]
is_a: GO:0014717 ! regulation of satellite cell activation involved in skeletal muscle regeneration
is_a: GO:0043417 ! negative regulation of skeletal muscle tissue regeneration
is_a: GO:0050866 ! negative regulation of cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0014901 ! satellite cell activation involved in skeletal muscle regeneration
relationship: negatively_regulates GO:0014901 ! satellite cell activation involved in skeletal muscle regeneration
created_by: dph
creation_date: 2012-11-21T16:21:11Z

[Term]
id: GO:1901668
name: regulation of superoxide dismutase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of superoxide dismutase activity." [GOC:TermGenie]
synonym: "regulation of copper, zinc superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "regulation of Cu,Zn-SOD" RELATED [GOC:TermGenie]
synonym: "regulation of Cu-Zn superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "regulation of cuprein" RELATED [GOC:TermGenie]
synonym: "regulation of cytocuprein" RELATED [GOC:TermGenie]
synonym: "regulation of erythrocuprein" RELATED [GOC:TermGenie]
synonym: "regulation of Fe-SOD" RELATED [GOC:TermGenie]
synonym: "regulation of ferrisuperoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "regulation of hemocuprein" RELATED [GOC:TermGenie]
synonym: "regulation of hepatocuprein" RELATED [GOC:TermGenie]
synonym: "regulation of iron superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "regulation of iron superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "regulation of manganese superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "regulation of manganese superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "regulation of Mn, Fe superoxide dismutase" NARROW [GOC:TermGenie]
synonym: "regulation of Mn-SOD" RELATED [GOC:TermGenie]
synonym: "regulation of nickel superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "regulation of nickel superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "regulation of SOD" RELATED [GOC:TermGenie]
synonym: "regulation of SOD-1" RELATED [GOC:TermGenie]
synonym: "regulation of SOD-2" RELATED [GOC:TermGenie]
synonym: "regulation of SOD-3" RELATED [GOC:TermGenie]
synonym: "regulation of SOD-4" RELATED [GOC:TermGenie]
synonym: "regulation of SODF" RELATED [GOC:TermGenie]
synonym: "regulation of SODS" RELATED [GOC:TermGenie]
synonym: "regulation of superoxide dismutase I" RELATED [GOC:TermGenie]
synonym: "regulation of superoxide dismutase II" RELATED [GOC:TermGenie]
synonym: "regulation of superoxide:superoxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of zinc superoxide oxidoreductase" RELATED [GOC:TermGenie]
is_a: GO:0051341 ! regulation of oxidoreductase activity
is_a: GO:2000121 ! regulation of removal of superoxide radicals
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004784 ! superoxide dismutase activity
relationship: regulates GO:0004784 ! superoxide dismutase activity
created_by: tb
creation_date: 2012-11-21T20:46:42Z

[Term]
id: GO:1901670
name: negative regulation of superoxide dismutase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of superoxide dismutase activity." [GOC:TermGenie]
synonym: "down regulation of copper, zinc superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of Cu,Zn-SOD" RELATED [GOC:TermGenie]
synonym: "down regulation of Cu-Zn superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of cuprein" RELATED [GOC:TermGenie]
synonym: "down regulation of cytocuprein" RELATED [GOC:TermGenie]
synonym: "down regulation of erythrocuprein" RELATED [GOC:TermGenie]
synonym: "down regulation of Fe-SOD" RELATED [GOC:TermGenie]
synonym: "down regulation of ferrisuperoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of hemocuprein" RELATED [GOC:TermGenie]
synonym: "down regulation of hepatocuprein" RELATED [GOC:TermGenie]
synonym: "down regulation of iron superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of iron superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "down regulation of manganese superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of manganese superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "down regulation of Mn, Fe superoxide dismutase" NARROW [GOC:TermGenie]
synonym: "down regulation of Mn-SOD" RELATED [GOC:TermGenie]
synonym: "down regulation of nickel superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of nickel superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "down regulation of SOD" RELATED [GOC:TermGenie]
synonym: "down regulation of SOD-1" RELATED [GOC:TermGenie]
synonym: "down regulation of SOD-2" RELATED [GOC:TermGenie]
synonym: "down regulation of SOD-3" RELATED [GOC:TermGenie]
synonym: "down regulation of SOD-4" RELATED [GOC:TermGenie]
synonym: "down regulation of SODF" RELATED [GOC:TermGenie]
synonym: "down regulation of SODS" RELATED [GOC:TermGenie]
synonym: "down regulation of superoxide dismutase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of superoxide dismutase I" RELATED [GOC:TermGenie]
synonym: "down regulation of superoxide dismutase II" RELATED [GOC:TermGenie]
synonym: "down regulation of superoxide:superoxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of zinc superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "down-regulation of copper, zinc superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of Cu,Zn-SOD" RELATED [GOC:TermGenie]
synonym: "down-regulation of Cu-Zn superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of cuprein" RELATED [GOC:TermGenie]
synonym: "down-regulation of cytocuprein" RELATED [GOC:TermGenie]
synonym: "down-regulation of erythrocuprein" RELATED [GOC:TermGenie]
synonym: "down-regulation of Fe-SOD" RELATED [GOC:TermGenie]
synonym: "down-regulation of ferrisuperoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of hemocuprein" RELATED [GOC:TermGenie]
synonym: "down-regulation of hepatocuprein" RELATED [GOC:TermGenie]
synonym: "down-regulation of iron superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of iron superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "down-regulation of manganese superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of manganese superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "down-regulation of Mn, Fe superoxide dismutase" NARROW [GOC:TermGenie]
synonym: "down-regulation of Mn-SOD" RELATED [GOC:TermGenie]
synonym: "down-regulation of nickel superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of nickel superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "down-regulation of SOD" RELATED [GOC:TermGenie]
synonym: "down-regulation of SOD-1" RELATED [GOC:TermGenie]
synonym: "down-regulation of SOD-2" RELATED [GOC:TermGenie]
synonym: "down-regulation of SOD-3" RELATED [GOC:TermGenie]
synonym: "down-regulation of SOD-4" RELATED [GOC:TermGenie]
synonym: "down-regulation of SODF" RELATED [GOC:TermGenie]
synonym: "down-regulation of SODS" RELATED [GOC:TermGenie]
synonym: "down-regulation of superoxide dismutase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of superoxide dismutase I" RELATED [GOC:TermGenie]
synonym: "down-regulation of superoxide dismutase II" RELATED [GOC:TermGenie]
synonym: "down-regulation of superoxide:superoxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of zinc superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "downregulation of copper, zinc superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of Cu,Zn-SOD" RELATED [GOC:TermGenie]
synonym: "downregulation of Cu-Zn superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of cuprein" RELATED [GOC:TermGenie]
synonym: "downregulation of cytocuprein" RELATED [GOC:TermGenie]
synonym: "downregulation of erythrocuprein" RELATED [GOC:TermGenie]
synonym: "downregulation of Fe-SOD" RELATED [GOC:TermGenie]
synonym: "downregulation of ferrisuperoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of hemocuprein" RELATED [GOC:TermGenie]
synonym: "downregulation of hepatocuprein" RELATED [GOC:TermGenie]
synonym: "downregulation of iron superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of iron superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "downregulation of manganese superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of manganese superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "downregulation of Mn, Fe superoxide dismutase" NARROW [GOC:TermGenie]
synonym: "downregulation of Mn-SOD" RELATED [GOC:TermGenie]
synonym: "downregulation of nickel superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of nickel superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "downregulation of SOD" RELATED [GOC:TermGenie]
synonym: "downregulation of SOD-1" RELATED [GOC:TermGenie]
synonym: "downregulation of SOD-2" RELATED [GOC:TermGenie]
synonym: "downregulation of SOD-3" RELATED [GOC:TermGenie]
synonym: "downregulation of SOD-4" RELATED [GOC:TermGenie]
synonym: "downregulation of SODF" RELATED [GOC:TermGenie]
synonym: "downregulation of SODS" RELATED [GOC:TermGenie]
synonym: "downregulation of superoxide dismutase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of superoxide dismutase I" RELATED [GOC:TermGenie]
synonym: "downregulation of superoxide dismutase II" RELATED [GOC:TermGenie]
synonym: "downregulation of superoxide:superoxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of zinc superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "inhibition of copper, zinc superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of Cu,Zn-SOD" RELATED [GOC:TermGenie]
synonym: "inhibition of Cu-Zn superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of cuprein" RELATED [GOC:TermGenie]
synonym: "inhibition of cytocuprein" RELATED [GOC:TermGenie]
synonym: "inhibition of erythrocuprein" RELATED [GOC:TermGenie]
synonym: "inhibition of Fe-SOD" RELATED [GOC:TermGenie]
synonym: "inhibition of ferrisuperoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of hemocuprein" RELATED [GOC:TermGenie]
synonym: "inhibition of hepatocuprein" RELATED [GOC:TermGenie]
synonym: "inhibition of iron superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of iron superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "inhibition of manganese superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of manganese superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "inhibition of Mn, Fe superoxide dismutase" NARROW [GOC:TermGenie]
synonym: "inhibition of Mn-SOD" RELATED [GOC:TermGenie]
synonym: "inhibition of nickel superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of nickel superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "inhibition of SOD" RELATED [GOC:TermGenie]
synonym: "inhibition of SOD-1" RELATED [GOC:TermGenie]
synonym: "inhibition of SOD-2" RELATED [GOC:TermGenie]
synonym: "inhibition of SOD-3" RELATED [GOC:TermGenie]
synonym: "inhibition of SOD-4" RELATED [GOC:TermGenie]
synonym: "inhibition of SODF" RELATED [GOC:TermGenie]
synonym: "inhibition of SODS" RELATED [GOC:TermGenie]
synonym: "inhibition of superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of superoxide dismutase I" RELATED [GOC:TermGenie]
synonym: "inhibition of superoxide dismutase II" RELATED [GOC:TermGenie]
synonym: "inhibition of superoxide:superoxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of zinc superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "negative regulation of copper, zinc superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of Cu,Zn-SOD" RELATED [GOC:TermGenie]
synonym: "negative regulation of Cu-Zn superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of cuprein" RELATED [GOC:TermGenie]
synonym: "negative regulation of cytocuprein" RELATED [GOC:TermGenie]
synonym: "negative regulation of erythrocuprein" RELATED [GOC:TermGenie]
synonym: "negative regulation of Fe-SOD" RELATED [GOC:TermGenie]
synonym: "negative regulation of ferrisuperoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of hemocuprein" RELATED [GOC:TermGenie]
synonym: "negative regulation of hepatocuprein" RELATED [GOC:TermGenie]
synonym: "negative regulation of iron superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of iron superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "negative regulation of manganese superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of manganese superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "negative regulation of Mn, Fe superoxide dismutase" NARROW [GOC:TermGenie]
synonym: "negative regulation of Mn-SOD" RELATED [GOC:TermGenie]
synonym: "negative regulation of nickel superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of nickel superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "negative regulation of SOD" RELATED [GOC:TermGenie]
synonym: "negative regulation of SOD-1" RELATED [GOC:TermGenie]
synonym: "negative regulation of SOD-2" RELATED [GOC:TermGenie]
synonym: "negative regulation of SOD-3" RELATED [GOC:TermGenie]
synonym: "negative regulation of SOD-4" RELATED [GOC:TermGenie]
synonym: "negative regulation of SODF" RELATED [GOC:TermGenie]
synonym: "negative regulation of SODS" RELATED [GOC:TermGenie]
synonym: "negative regulation of superoxide dismutase I" RELATED [GOC:TermGenie]
synonym: "negative regulation of superoxide dismutase II" RELATED [GOC:TermGenie]
synonym: "negative regulation of superoxide:superoxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of zinc superoxide oxidoreductase" RELATED [GOC:TermGenie]
is_a: GO:0051354 ! negative regulation of oxidoreductase activity
is_a: GO:1901668 ! regulation of superoxide dismutase activity
is_a: GO:1904832 ! negative regulation of removal of superoxide radicals
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004784 ! superoxide dismutase activity
relationship: negatively_regulates GO:0004784 ! superoxide dismutase activity
created_by: tb
creation_date: 2012-11-21T21:36:07Z

[Term]
id: GO:1901671
name: positive regulation of superoxide dismutase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of superoxide dismutase activity." [GOC:TermGenie]
synonym: "activation of copper, zinc superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "activation of Cu,Zn-SOD" RELATED [GOC:TermGenie]
synonym: "activation of Cu-Zn superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "activation of cuprein" RELATED [GOC:TermGenie]
synonym: "activation of cytocuprein" RELATED [GOC:TermGenie]
synonym: "activation of erythrocuprein" RELATED [GOC:TermGenie]
synonym: "activation of Fe-SOD" RELATED [GOC:TermGenie]
synonym: "activation of ferrisuperoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "activation of hemocuprein" RELATED [GOC:TermGenie]
synonym: "activation of hepatocuprein" RELATED [GOC:TermGenie]
synonym: "activation of iron superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "activation of iron superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "activation of manganese superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "activation of manganese superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "activation of Mn, Fe superoxide dismutase" NARROW [GOC:TermGenie]
synonym: "activation of Mn-SOD" RELATED [GOC:TermGenie]
synonym: "activation of nickel superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "activation of nickel superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "activation of SOD" RELATED [GOC:TermGenie]
synonym: "activation of SOD-1" RELATED [GOC:TermGenie]
synonym: "activation of SOD-2" RELATED [GOC:TermGenie]
synonym: "activation of SOD-3" RELATED [GOC:TermGenie]
synonym: "activation of SOD-4" RELATED [GOC:TermGenie]
synonym: "activation of SODF" RELATED [GOC:TermGenie]
synonym: "activation of SODS" RELATED [GOC:TermGenie]
synonym: "activation of superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "activation of superoxide dismutase I" RELATED [GOC:TermGenie]
synonym: "activation of superoxide dismutase II" RELATED [GOC:TermGenie]
synonym: "activation of superoxide:superoxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "activation of zinc superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "positive regulation of copper, zinc superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of Cu,Zn-SOD" RELATED [GOC:TermGenie]
synonym: "positive regulation of Cu-Zn superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of cuprein" RELATED [GOC:TermGenie]
synonym: "positive regulation of cytocuprein" RELATED [GOC:TermGenie]
synonym: "positive regulation of erythrocuprein" RELATED [GOC:TermGenie]
synonym: "positive regulation of Fe-SOD" RELATED [GOC:TermGenie]
synonym: "positive regulation of ferrisuperoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of hemocuprein" RELATED [GOC:TermGenie]
synonym: "positive regulation of hepatocuprein" RELATED [GOC:TermGenie]
synonym: "positive regulation of iron superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of iron superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "positive regulation of manganese superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of manganese superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "positive regulation of Mn, Fe superoxide dismutase" NARROW [GOC:TermGenie]
synonym: "positive regulation of Mn-SOD" RELATED [GOC:TermGenie]
synonym: "positive regulation of nickel superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of nickel superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "positive regulation of SOD" RELATED [GOC:TermGenie]
synonym: "positive regulation of SOD-1" RELATED [GOC:TermGenie]
synonym: "positive regulation of SOD-2" RELATED [GOC:TermGenie]
synonym: "positive regulation of SOD-3" RELATED [GOC:TermGenie]
synonym: "positive regulation of SOD-4" RELATED [GOC:TermGenie]
synonym: "positive regulation of SODF" RELATED [GOC:TermGenie]
synonym: "positive regulation of SODS" RELATED [GOC:TermGenie]
synonym: "positive regulation of superoxide dismutase I" RELATED [GOC:TermGenie]
synonym: "positive regulation of superoxide dismutase II" RELATED [GOC:TermGenie]
synonym: "positive regulation of superoxide:superoxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of zinc superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "up regulation of copper, zinc superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of Cu,Zn-SOD" RELATED [GOC:TermGenie]
synonym: "up regulation of Cu-Zn superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of cuprein" RELATED [GOC:TermGenie]
synonym: "up regulation of cytocuprein" RELATED [GOC:TermGenie]
synonym: "up regulation of erythrocuprein" RELATED [GOC:TermGenie]
synonym: "up regulation of Fe-SOD" RELATED [GOC:TermGenie]
synonym: "up regulation of ferrisuperoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of hemocuprein" RELATED [GOC:TermGenie]
synonym: "up regulation of hepatocuprein" RELATED [GOC:TermGenie]
synonym: "up regulation of iron superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of iron superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "up regulation of manganese superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of manganese superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "up regulation of Mn, Fe superoxide dismutase" NARROW [GOC:TermGenie]
synonym: "up regulation of Mn-SOD" RELATED [GOC:TermGenie]
synonym: "up regulation of nickel superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of nickel superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "up regulation of SOD" RELATED [GOC:TermGenie]
synonym: "up regulation of SOD-1" RELATED [GOC:TermGenie]
synonym: "up regulation of SOD-2" RELATED [GOC:TermGenie]
synonym: "up regulation of SOD-3" RELATED [GOC:TermGenie]
synonym: "up regulation of SOD-4" RELATED [GOC:TermGenie]
synonym: "up regulation of SODF" RELATED [GOC:TermGenie]
synonym: "up regulation of SODS" RELATED [GOC:TermGenie]
synonym: "up regulation of superoxide dismutase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of superoxide dismutase I" RELATED [GOC:TermGenie]
synonym: "up regulation of superoxide dismutase II" RELATED [GOC:TermGenie]
synonym: "up regulation of superoxide:superoxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of zinc superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "up-regulation of copper, zinc superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of Cu,Zn-SOD" RELATED [GOC:TermGenie]
synonym: "up-regulation of Cu-Zn superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of cuprein" RELATED [GOC:TermGenie]
synonym: "up-regulation of cytocuprein" RELATED [GOC:TermGenie]
synonym: "up-regulation of erythrocuprein" RELATED [GOC:TermGenie]
synonym: "up-regulation of Fe-SOD" RELATED [GOC:TermGenie]
synonym: "up-regulation of ferrisuperoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of hemocuprein" RELATED [GOC:TermGenie]
synonym: "up-regulation of hepatocuprein" RELATED [GOC:TermGenie]
synonym: "up-regulation of iron superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of iron superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "up-regulation of manganese superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of manganese superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "up-regulation of Mn, Fe superoxide dismutase" NARROW [GOC:TermGenie]
synonym: "up-regulation of Mn-SOD" RELATED [GOC:TermGenie]
synonym: "up-regulation of nickel superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of nickel superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "up-regulation of SOD" RELATED [GOC:TermGenie]
synonym: "up-regulation of SOD-1" RELATED [GOC:TermGenie]
synonym: "up-regulation of SOD-2" RELATED [GOC:TermGenie]
synonym: "up-regulation of SOD-3" RELATED [GOC:TermGenie]
synonym: "up-regulation of SOD-4" RELATED [GOC:TermGenie]
synonym: "up-regulation of SODF" RELATED [GOC:TermGenie]
synonym: "up-regulation of SODS" RELATED [GOC:TermGenie]
synonym: "up-regulation of superoxide dismutase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of superoxide dismutase I" RELATED [GOC:TermGenie]
synonym: "up-regulation of superoxide dismutase II" RELATED [GOC:TermGenie]
synonym: "up-regulation of superoxide:superoxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of zinc superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "upregulation of copper, zinc superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of Cu,Zn-SOD" RELATED [GOC:TermGenie]
synonym: "upregulation of Cu-Zn superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of cuprein" RELATED [GOC:TermGenie]
synonym: "upregulation of cytocuprein" RELATED [GOC:TermGenie]
synonym: "upregulation of erythrocuprein" RELATED [GOC:TermGenie]
synonym: "upregulation of Fe-SOD" RELATED [GOC:TermGenie]
synonym: "upregulation of ferrisuperoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of hemocuprein" RELATED [GOC:TermGenie]
synonym: "upregulation of hepatocuprein" RELATED [GOC:TermGenie]
synonym: "upregulation of iron superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of iron superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "upregulation of manganese superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of manganese superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "upregulation of Mn, Fe superoxide dismutase" NARROW [GOC:TermGenie]
synonym: "upregulation of Mn-SOD" RELATED [GOC:TermGenie]
synonym: "upregulation of nickel superoxide dismutase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of nickel superoxide oxidoreductase" RELATED [GOC:TermGenie]
synonym: "upregulation of SOD" RELATED [GOC:TermGenie]
synonym: "upregulation of SOD-1" RELATED [GOC:TermGenie]
synonym: "upregulation of SOD-2" RELATED [GOC:TermGenie]
synonym: "upregulation of SOD-3" RELATED [GOC:TermGenie]
synonym: "upregulation of SOD-4" RELATED [GOC:TermGenie]
synonym: "upregulation of SODF" RELATED [GOC:TermGenie]
synonym: "upregulation of SODS" RELATED [GOC:TermGenie]
synonym: "upregulation of superoxide dismutase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of superoxide dismutase I" RELATED [GOC:TermGenie]
synonym: "upregulation of superoxide dismutase II" RELATED [GOC:TermGenie]
synonym: "upregulation of superoxide:superoxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of zinc superoxide oxidoreductase" RELATED [GOC:TermGenie]
is_a: GO:0051353 ! positive regulation of oxidoreductase activity
is_a: GO:1901668 ! regulation of superoxide dismutase activity
is_a: GO:1904833 ! positive regulation of removal of superoxide radicals
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004784 ! superoxide dismutase activity
relationship: positively_regulates GO:0004784 ! superoxide dismutase activity
created_by: tb
creation_date: 2012-11-21T21:36:11Z

[Term]
id: GO:1901672
name: positive regulation of systemic acquired resistance
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of systemic acquired resistance." [GOC:TermGenie]
synonym: "activation of salicylic acid-dependent systemic resistance" EXACT [GOC:TermGenie]
synonym: "activation of systemic acquired resistance" NARROW [GOC:TermGenie]
synonym: "positive regulation of salicylic acid-dependent systemic resistance" EXACT [GOC:TermGenie]
synonym: "up regulation of salicylic acid-dependent systemic resistance" EXACT [GOC:TermGenie]
synonym: "up regulation of systemic acquired resistance" EXACT [GOC:TermGenie]
synonym: "up-regulation of salicylic acid-dependent systemic resistance" EXACT [GOC:TermGenie]
synonym: "up-regulation of systemic acquired resistance" EXACT [GOC:TermGenie]
synonym: "upregulation of salicylic acid-dependent systemic resistance" EXACT [GOC:TermGenie]
synonym: "upregulation of systemic acquired resistance" EXACT [GOC:TermGenie]
is_a: GO:0002833 ! positive regulation of response to biotic stimulus
is_a: GO:0010112 ! regulation of systemic acquired resistance
is_a: GO:0032103 ! positive regulation of response to external stimulus
is_a: GO:0043902 ! positive regulation of multi-organism process
is_a: GO:0045089 ! positive regulation of innate immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009627 ! systemic acquired resistance
relationship: positively_regulates GO:0009627 ! systemic acquired resistance
created_by: tb
creation_date: 2012-11-21T22:03:58Z

[Term]
id: GO:1901673
name: regulation of mitotic spindle assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitotic spindle assembly." [GOC:TermGenie]
synonym: "regulation of spindle assembly involved in mitosis" EXACT []
is_a: GO:0007088 ! regulation of mitotic nuclear division
is_a: GO:0060236 ! regulation of mitotic spindle organization
is_a: GO:0090169 ! regulation of spindle assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0090307 ! mitotic spindle assembly
relationship: regulates GO:0090307 ! mitotic spindle assembly
created_by: al
creation_date: 2012-11-22T09:50:00Z

[Term]
id: GO:1901674
name: regulation of histone H3-K27 acetylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of histone H3-K27 acetylation." [GOC:BHF, GOC:TermGenie]
synonym: "regulation of histone H3 acetylation at K27" EXACT [GOC:TermGenie]
synonym: "regulation of histone H3K27 acetylation" EXACT [GOC:TermGenie]
is_a: GO:0035065 ! regulation of histone acetylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043974 ! histone H3-K27 acetylation
relationship: regulates GO:0043974 ! histone H3-K27 acetylation
created_by: vk
creation_date: 2012-11-22T12:06:31Z

[Term]
id: GO:1901675
name: negative regulation of histone H3-K27 acetylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K27 acetylation." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of histone H3 acetylation at K27" EXACT [GOC:TermGenie]
synonym: "down regulation of histone H3-K27 acetylation" EXACT [GOC:TermGenie]
synonym: "down regulation of histone H3K27 acetylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of histone H3 acetylation at K27" EXACT [GOC:TermGenie]
synonym: "down-regulation of histone H3-K27 acetylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of histone H3K27 acetylation" EXACT [GOC:TermGenie]
synonym: "downregulation of histone H3 acetylation at K27" EXACT [GOC:TermGenie]
synonym: "downregulation of histone H3-K27 acetylation" EXACT [GOC:TermGenie]
synonym: "downregulation of histone H3K27 acetylation" EXACT [GOC:TermGenie]
synonym: "inhibition of histone H3 acetylation at K27" EXACT [GOC:TermGenie]
synonym: "inhibition of histone H3-K27 acetylation" NARROW [GOC:TermGenie]
synonym: "inhibition of histone H3K27 acetylation" EXACT [GOC:TermGenie]
synonym: "negative regulation of histone H3 acetylation at K27" EXACT [GOC:TermGenie]
synonym: "negative regulation of histone H3K27 acetylation" EXACT [GOC:TermGenie]
is_a: GO:0035067 ! negative regulation of histone acetylation
is_a: GO:1901674 ! regulation of histone H3-K27 acetylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043974 ! histone H3-K27 acetylation
relationship: negatively_regulates GO:0043974 ! histone H3-K27 acetylation
created_by: vk
creation_date: 2012-11-22T12:06:40Z

[Term]
id: GO:1901676
name: positive regulation of histone H3-K27 acetylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of histone H3-K27 acetylation." [GOC:BHF, GOC:TermGenie]
synonym: "activation of histone H3 acetylation at K27" EXACT [GOC:TermGenie]
synonym: "activation of histone H3-K27 acetylation" NARROW [GOC:TermGenie]
synonym: "activation of histone H3K27 acetylation" EXACT [GOC:TermGenie]
synonym: "positive regulation of histone H3 acetylation at K27" EXACT [GOC:TermGenie]
synonym: "positive regulation of histone H3K27 acetylation" EXACT [GOC:TermGenie]
synonym: "up regulation of histone H3 acetylation at K27" EXACT [GOC:TermGenie]
synonym: "up regulation of histone H3-K27 acetylation" EXACT [GOC:TermGenie]
synonym: "up regulation of histone H3K27 acetylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of histone H3 acetylation at K27" EXACT [GOC:TermGenie]
synonym: "up-regulation of histone H3-K27 acetylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of histone H3K27 acetylation" EXACT [GOC:TermGenie]
synonym: "upregulation of histone H3 acetylation at K27" EXACT [GOC:TermGenie]
synonym: "upregulation of histone H3-K27 acetylation" EXACT [GOC:TermGenie]
synonym: "upregulation of histone H3K27 acetylation" EXACT [GOC:TermGenie]
is_a: GO:0035066 ! positive regulation of histone acetylation
is_a: GO:1901674 ! regulation of histone H3-K27 acetylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043974 ! histone H3-K27 acetylation
relationship: positively_regulates GO:0043974 ! histone H3-K27 acetylation
created_by: vk
creation_date: 2012-11-22T12:06:45Z

[Term]
id: GO:1901677
name: phosphate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of phosphate from one side of the membrane to the other." [GOC:pr, GOC:TermGenie]
is_a: GO:0022857 ! transmembrane transporter activity
created_by: pr
creation_date: 2012-11-22T15:43:10Z

[Term]
id: GO:1901678
name: iron coordination entity transport
namespace: biological_process
def: "The directed movement of an iron coordination entity into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:pr, GOC:TermGenie]
is_a: GO:0044765 ! single-organism transport
created_by: pr
creation_date: 2012-11-22T15:43:15Z

[Term]
id: GO:1901679
name: nucleotide transmembrane transport
namespace: biological_process
def: "The directed movement of nucleotide across a membrane." [GOC:pr, GOC:TermGenie]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "nucleotide membrane transport" EXACT []
is_a: GO:0006862 ! nucleotide transport
is_a: GO:0055085 ! transmembrane transport
created_by: pr
creation_date: 2012-11-22T15:43:23Z

[Term]
id: GO:1901680
name: sulfur-containing amino acid secondary active transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of sulfur-containing amino acid from one side of the membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:pr, GOC:TermGenie]
is_a: GO:0000099 ! sulfur amino acid transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity
created_by: pr
creation_date: 2012-11-22T16:16:48Z

[Term]
id: GO:1901681
name: sulfur compound binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sulfur compound." [GOC:pr, GOC:TermGenie]
synonym: "sulfur molecular entity binding" EXACT []
is_a: GO:0005488 ! binding
created_by: pr
creation_date: 2012-11-26T20:45:23Z

[Term]
id: GO:1901682
name: sulfur compound transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a sulfur compound from one side of the membrane to the other." [GOC:pr, GOC:TermGenie]
synonym: "sulfur molecular entity transmembrane transporter activity" EXACT []
is_a: GO:0022857 ! transmembrane transporter activity
created_by: pr
creation_date: 2012-11-26T20:45:29Z

[Term]
id: GO:1901683
name: arsenate ion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of an arsenate ion from one side of the membrane to the other." [GOC:TermGenie]
is_a: GO:0008509 ! anion transmembrane transporter activity
relationship: part_of GO:1901684 ! arsenate ion transmembrane transport
created_by: tb
creation_date: 2012-12-04T23:26:27Z

[Term]
id: GO:1901684
name: arsenate ion transmembrane transport
namespace: biological_process
def: "The directed movement of arsenate ion across a membrane." [GOC:TermGenie]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
is_a: GO:0098656 ! anion transmembrane transport
created_by: tb
creation_date: 2012-12-04T23:26:36Z

[Term]
id: GO:1901685
name: glutathione derivative metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glutathione derivative." [GOC:pr, GOC:TermGenie]
synonym: "glutathione derivative metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0044710 ! single-organism metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:1901564 ! organonitrogen compound metabolic process
created_by: pr
creation_date: 2012-12-05T11:57:11Z

[Term]
id: GO:1901686
name: glutathione derivative catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glutathione derivative." [GOC:pr, GOC:TermGenie]
synonym: "glutathione derivative breakdown" EXACT [GOC:TermGenie]
synonym: "glutathione derivative catabolism" EXACT [GOC:TermGenie]
synonym: "glutathione derivative degradation" EXACT [GOC:TermGenie]
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0044712 ! single-organism catabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process
is_a: GO:1901685 ! glutathione derivative metabolic process
created_by: pr
creation_date: 2012-12-05T11:57:16Z

[Term]
id: GO:1901687
name: glutathione derivative biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glutathione derivative." [GOC:pr, GOC:TermGenie]
synonym: "glutathione derivative anabolism" EXACT [GOC:TermGenie]
synonym: "glutathione derivative biosynthesis" EXACT [GOC:TermGenie]
synonym: "glutathione derivative formation" EXACT [GOC:TermGenie]
synonym: "glutathione derivative synthesis" EXACT [GOC:TermGenie]
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process
is_a: GO:1901685 ! glutathione derivative metabolic process
created_by: pr
creation_date: 2012-12-05T11:57:20Z

[Term]
id: GO:1901688
name: pantothenate import
namespace: biological_process
def: "The directed movement of pantothenate into a cell or organelle." [GOC:TermGenie]
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0042886 ! amide transport
is_a: GO:0072337 ! modified amino acid transport
created_by: jl
creation_date: 2012-12-05T16:27:41Z

[Term]
id: GO:1901689
name: biotin import
namespace: biological_process
def: "The directed movement of biotin into a cell or organelle." [GOC:TermGenie]
is_a: GO:0015878 ! biotin transport
created_by: jl
creation_date: 2012-12-05T16:30:20Z

[Term]
id: GO:1901690
name: dethiobiotin import
namespace: biological_process
def: "The directed movement of dethiobiotin into a cell or organelle." [GOC:TermGenie]
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0042886 ! amide transport
created_by: jl
creation_date: 2012-12-05T16:32:00Z

[Term]
id: GO:1901691
name: proton binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with proton." [GOC:TermGenie]
synonym: "hydrogen ion binding" EXACT [GOC:bm]
is_a: GO:0043169 ! cation binding
created_by: al
creation_date: 2012-12-07T13:50:53Z

[Term]
id: GO:1901692
name: regulation of compound eye retinal cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of compound eye retinal cell apoptotic process." [GOC:mtg_apoptosis, GOC:TermGenie, PMID:12021768]
is_a: GO:0042981 ! regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990010 ! compound eye retinal cell apoptotic process
relationship: regulates GO:1990010 ! compound eye retinal cell apoptotic process
created_by: pr
creation_date: 2012-12-12T10:28:35Z

[Term]
id: GO:1901693
name: negative regulation of compound eye retinal cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of compound eye retinal cell apoptotic process." [GOC:mtg_apoptosis, GOC:TermGenie, PMID:12021768]
synonym: "down regulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "inhibition of compound eye retinal cell apoptotic process" NARROW [GOC:TermGenie]
is_a: GO:0043066 ! negative regulation of apoptotic process
is_a: GO:1901692 ! regulation of compound eye retinal cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990010 ! compound eye retinal cell apoptotic process
relationship: negatively_regulates GO:1990010 ! compound eye retinal cell apoptotic process
created_by: pr
creation_date: 2012-12-12T10:28:40Z

[Term]
id: GO:1901694
name: positive regulation of compound eye retinal cell apoptotic process
namespace: biological_process
alt_id: GO:0046675
def: "Any process that activates or increases the frequency, rate or extent of compound eye retinal cell apoptotic process." [GOC:mtg_apoptosis, GOC:TermGenie, PMID:12021768]
synonym: "activation of compound eye retinal cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "induction of compound eye retinal cell programmed cell death" RELATED []
synonym: "up regulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0043065 ! positive regulation of apoptotic process
is_a: GO:0046672 ! positive regulation of compound eye retinal cell programmed cell death
is_a: GO:1901692 ! regulation of compound eye retinal cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990010 ! compound eye retinal cell apoptotic process
relationship: positively_regulates GO:1990010 ! compound eye retinal cell apoptotic process
created_by: pr
creation_date: 2012-12-12T10:28:45Z

[Term]
id: GO:1901695
name: tyramine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tyramine." [GOC:TermGenie, PMID:21284755]
synonym: "tyramine anabolism" EXACT [GOC:TermGenie]
synonym: "tyramine biosynthesis" EXACT [GOC:TermGenie]
synonym: "tyramine formation" EXACT [GOC:TermGenie]
synonym: "tyramine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:0097164 ! ammonium ion metabolic process
is_a: GO:1901162 ! primary amino compound biosynthetic process
created_by: tb
creation_date: 2012-12-12T19:31:35Z

[Term]
id: GO:1901696
name: cannabinoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cannabinoid." [GOC:TermGenie]
synonym: "cannabinoid anabolism" EXACT [GOC:TermGenie]
synonym: "cannabinoid biosynthesis" EXACT [GOC:TermGenie]
synonym: "cannabinoid formation" EXACT [GOC:TermGenie]
synonym: "cannabinoid synthesis" EXACT [GOC:TermGenie]
is_a: GO:1901576 ! organic substance biosynthetic process
created_by: ms
creation_date: 2012-12-13T08:07:47Z

[Term]
id: GO:1901697
name: olivetolic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of olivetolic acid." [GOC:TermGenie]
synonym: "olivetolic acid anabolism" EXACT [GOC:TermGenie]
synonym: "olivetolic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "olivetolic acid formation" EXACT [GOC:TermGenie]
synonym: "olivetolic acid synthesis" EXACT [GOC:TermGenie]
is_a: GO:0030639 ! polyketide biosynthetic process
is_a: GO:0042537 ! benzene-containing compound metabolic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
created_by: ms
creation_date: 2012-12-13T08:07:51Z

[Term]
id: GO:1901698
name: response to nitrogen compound
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie]
synonym: "response to nitrogen molecular entity" EXACT []
is_a: GO:0042221 ! response to chemical
created_by: pr
creation_date: 2012-12-13T15:06:08Z

[Term]
id: GO:1901699
name: cellular response to nitrogen compound
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie]
synonym: "cellular response to nitrogen molecular entity" EXACT []
is_a: GO:0070887 ! cellular response to chemical stimulus
is_a: GO:1901698 ! response to nitrogen compound
created_by: pr
creation_date: 2012-12-13T15:06:13Z

[Term]
id: GO:1901700
name: response to oxygen-containing compound
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]
synonym: "response to oxygen molecular entity" EXACT []
is_a: GO:0042221 ! response to chemical
created_by: pr
creation_date: 2012-12-13T15:11:37Z

[Term]
id: GO:1901701
name: cellular response to oxygen-containing compound
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]
synonym: "cellular response to oxygen molecular entity" EXACT []
is_a: GO:0070887 ! cellular response to chemical stimulus
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: pr
creation_date: 2012-12-13T15:11:42Z

[Term]
id: GO:1901702
name: salt transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of salt from one side of the membrane to the other." [GOC:pr, GOC:TermGenie]
is_a: GO:0022857 ! transmembrane transporter activity
created_by: pr
creation_date: 2012-12-13T15:14:47Z

[Term]
id: GO:1901703
name: protein localization involved in auxin polar transport
namespace: biological_process
def: "Any protein localization that is involved in auxin polar transport." [GOC:TermGenie, PMID:23163883]
synonym: "establishment and maintenance of protein localization involved in auxin polar transport" EXACT [GOC:TermGenie]
synonym: "protein localisation involved in auxin polar transport" EXACT [GOC:TermGenie]
is_a: GO:0008104 ! protein localization
intersection_of: GO:0008104 ! protein localization
intersection_of: part_of GO:0009926 ! auxin polar transport
relationship: part_of GO:0009926 ! auxin polar transport
created_by: tb
creation_date: 2012-12-13T19:06:13Z

[Term]
id: GO:1901704
name: L-glutamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-glutamine." [GOC:TermGenie]
synonym: "L-glutamine anabolism" EXACT [GOC:TermGenie]
synonym: "L-glutamine biosynthesis" EXACT [GOC:TermGenie]
synonym: "L-glutamine formation" EXACT [GOC:TermGenie]
synonym: "L-glutamine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0006542 ! glutamine biosynthetic process
created_by: pde
creation_date: 2012-12-13T23:32:52Z

[Term]
id: GO:1901705
name: L-isoleucine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-isoleucine." [GOC:TermGenie]
synonym: "L-isoleucine anabolism" EXACT [GOC:TermGenie]
synonym: "L-isoleucine biosynthesis" EXACT [GOC:TermGenie]
synonym: "L-isoleucine formation" EXACT [GOC:TermGenie]
synonym: "L-isoleucine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009067 ! aspartate family amino acid biosynthetic process
is_a: GO:0009097 ! isoleucine biosynthetic process
created_by: pde
creation_date: 2012-12-13T23:32:56Z

[Term]
id: GO:1901706
name: mesenchymal cell differentiation involved in bone development
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of bone as it progresses from its formation to the mature state." [GOC:hjd, GOC:TermGenie, PMID:21571217]
is_a: GO:0048762 ! mesenchymal cell differentiation
intersection_of: GO:0048762 ! mesenchymal cell differentiation
intersection_of: part_of GO:0060348 ! bone development
relationship: part_of GO:0060348 ! bone development
created_by: hjd
creation_date: 2012-12-14T16:04:16Z

[Term]
id: GO:1901707
name: leptomycin B binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with leptomycin B." [GOC:TermGenie]
is_a: GO:0005504 ! fatty acid binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding
created_by: mah
creation_date: 2012-12-18T15:10:04Z

[Term]
id: GO:1901708
name: (+)-3'-hydroxylarreatricin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (+)-3'-hydroxylarreatricin." [GOC:TermGenie, pmid:12960376]
synonym: "(+)-3'-hydroxylarreatricin anabolism" EXACT [GOC:TermGenie]
synonym: "(+)-3'-hydroxylarreatricin biosynthesis" EXACT [GOC:TermGenie]
synonym: "(+)-3'-hydroxylarreatricin formation" EXACT [GOC:TermGenie]
synonym: "(+)-3'-hydroxylarreatricin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009807 ! lignan biosynthetic process
is_a: GO:0018130 ! heterocycle biosynthetic process
created_by: ms
creation_date: 2012-12-19T14:39:32Z

[Term]
id: GO:1901709
name: (+)-larreatricin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (+)-larreatricin." [GOC:TermGenie, pmid:12960376]
synonym: "(+)-larreatricin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009806 ! lignan metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
created_by: ms
creation_date: 2012-12-19T14:44:29Z

[Term]
id: GO:1901710
name: regulation of homoserine biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of homoserine biosynthetic process." [GOC:TermGenie]
synonym: "regulation of homoserine anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of homoserine biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of homoserine formation" EXACT [GOC:TermGenie]
synonym: "regulation of homoserine synthesis" EXACT [GOC:TermGenie]
is_a: GO:2000282 ! regulation of cellular amino acid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009090 ! homoserine biosynthetic process
relationship: regulates GO:0009090 ! homoserine biosynthetic process
created_by: maria.costanzo
creation_date: 2012-12-19T16:01:56Z

[Term]
id: GO:1901711
name: negative regulation of homoserine biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of homoserine biosynthetic process." [GOC:TermGenie]
synonym: "down regulation of homoserine anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of homoserine biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of homoserine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of homoserine formation" EXACT [GOC:TermGenie]
synonym: "down regulation of homoserine synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of homoserine anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of homoserine biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of homoserine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of homoserine formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of homoserine synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of homoserine anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of homoserine biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of homoserine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of homoserine formation" EXACT [GOC:TermGenie]
synonym: "downregulation of homoserine synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of homoserine anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of homoserine biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of homoserine biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of homoserine formation" EXACT [GOC:TermGenie]
synonym: "inhibition of homoserine synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of homoserine anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of homoserine biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of homoserine formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of homoserine synthesis" EXACT [GOC:TermGenie]
is_a: GO:1901710 ! regulation of homoserine biosynthetic process
is_a: GO:2000283 ! negative regulation of cellular amino acid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009090 ! homoserine biosynthetic process
relationship: negatively_regulates GO:0009090 ! homoserine biosynthetic process
created_by: maria.costanzo
creation_date: 2012-12-19T16:02:00Z

[Term]
id: GO:1901712
name: positive regulation of homoserine biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of homoserine biosynthetic process." [GOC:TermGenie]
synonym: "activation of homoserine anabolism" EXACT [GOC:TermGenie]
synonym: "activation of homoserine biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of homoserine biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of homoserine formation" EXACT [GOC:TermGenie]
synonym: "activation of homoserine synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of homoserine anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of homoserine biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of homoserine formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of homoserine synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of homoserine anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of homoserine biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of homoserine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of homoserine formation" EXACT [GOC:TermGenie]
synonym: "up regulation of homoserine synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of homoserine anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of homoserine biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of homoserine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of homoserine formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of homoserine synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of homoserine anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of homoserine biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of homoserine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of homoserine formation" EXACT [GOC:TermGenie]
synonym: "upregulation of homoserine synthesis" EXACT [GOC:TermGenie]
is_a: GO:1901710 ! regulation of homoserine biosynthetic process
is_a: GO:2000284 ! positive regulation of cellular amino acid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009090 ! homoserine biosynthetic process
relationship: positively_regulates GO:0009090 ! homoserine biosynthetic process
created_by: maria.costanzo
creation_date: 2012-12-19T16:02:05Z

[Term]
id: GO:1901713
name: negative regulation of urea catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of urea catabolic process." [GOC:TermGenie]
synonym: "down regulation of urea breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of urea catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of urea catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of urea decomposition" EXACT [GOC:TermGenie]
synonym: "down regulation of urea degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of urea breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of urea catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of urea catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of urea decomposition" EXACT [GOC:TermGenie]
synonym: "down-regulation of urea degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of urea breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of urea catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of urea catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of urea decomposition" EXACT [GOC:TermGenie]
synonym: "downregulation of urea degradation" EXACT [GOC:TermGenie]
synonym: "inhibition of urea breakdown" EXACT [GOC:TermGenie]
synonym: "inhibition of urea catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of urea catabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of urea decomposition" EXACT [GOC:TermGenie]
synonym: "inhibition of urea degradation" EXACT [GOC:TermGenie]
synonym: "negative regulation of urea breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of urea catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of urea decomposition" EXACT [GOC:TermGenie]
synonym: "negative regulation of urea degradation" EXACT [GOC:TermGenie]
is_a: GO:0034252 ! negative regulation of cellular amide catabolic process
is_a: GO:0034254 ! regulation of urea catabolic process
is_a: GO:1903315 ! negative regulation of nitrogen cycle metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043419 ! urea catabolic process
relationship: negatively_regulates GO:0043419 ! urea catabolic process
created_by: maria.costanzo
creation_date: 2012-12-19T16:12:13Z

[Term]
id: GO:1901714
name: positive regulation of urea catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of urea catabolic process." [GOC:TermGenie]
synonym: "activation of urea breakdown" EXACT [GOC:TermGenie]
synonym: "activation of urea catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of urea catabolism" EXACT [GOC:TermGenie]
synonym: "activation of urea decomposition" EXACT [GOC:TermGenie]
synonym: "activation of urea degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of urea breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of urea catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of urea decomposition" EXACT [GOC:TermGenie]
synonym: "positive regulation of urea degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of urea breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of urea catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of urea catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of urea decomposition" EXACT [GOC:TermGenie]
synonym: "up regulation of urea degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of urea breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of urea catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of urea catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of urea decomposition" EXACT [GOC:TermGenie]
synonym: "up-regulation of urea degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of urea breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of urea catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of urea catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of urea decomposition" EXACT [GOC:TermGenie]
synonym: "upregulation of urea degradation" EXACT [GOC:TermGenie]
is_a: GO:0034253 ! positive regulation of cellular amide catabolic process
is_a: GO:0034254 ! regulation of urea catabolic process
is_a: GO:1903316 ! positive regulation of nitrogen cycle metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043419 ! urea catabolic process
relationship: positively_regulates GO:0043419 ! urea catabolic process
created_by: maria.costanzo
creation_date: 2012-12-19T16:12:18Z

[Term]
id: GO:1901715
name: regulation of gamma-aminobutyric acid catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gamma-aminobutyric acid catabolic process." [GOC:TermGenie]
synonym: "regulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of GABA catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of GABA catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie]
is_a: GO:0006521 ! regulation of cellular amino acid metabolic process
is_a: GO:0031329 ! regulation of cellular catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009450 ! gamma-aminobutyric acid catabolic process
relationship: regulates GO:0009450 ! gamma-aminobutyric acid catabolic process
created_by: maria.costanzo
creation_date: 2012-12-19T16:13:24Z

[Term]
id: GO:1901716
name: negative regulation of gamma-aminobutyric acid catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of gamma-aminobutyric acid catabolic process." [GOC:TermGenie]
synonym: "down regulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of GABA catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of GABA catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of gamma-aminobutyric acid catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of GABA catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of GABA catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of gamma-aminobutyric acid catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of GABA catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of GABA catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of gamma-aminobutyric acid catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie]
synonym: "inhibition of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie]
synonym: "inhibition of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie]
synonym: "inhibition of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of GABA catabolic process" EXACT [GOC:TermGenie]
synonym: "inhibition of GABA catabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie]
synonym: "inhibition of gamma-aminobutyric acid catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie]
synonym: "negative regulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of GABA catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of GABA catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie]
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:0045763 ! negative regulation of cellular amino acid metabolic process
is_a: GO:1901715 ! regulation of gamma-aminobutyric acid catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009450 ! gamma-aminobutyric acid catabolic process
relationship: negatively_regulates GO:0009450 ! gamma-aminobutyric acid catabolic process
created_by: maria.costanzo
creation_date: 2012-12-19T16:13:31Z

[Term]
id: GO:1901717
name: positive regulation of gamma-aminobutyric acid catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of gamma-aminobutyric acid catabolic process." [GOC:TermGenie]
synonym: "activation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie]
synonym: "activation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie]
synonym: "activation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie]
synonym: "activation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie]
synonym: "activation of GABA catabolic process" EXACT [GOC:TermGenie]
synonym: "activation of GABA catabolism" EXACT [GOC:TermGenie]
synonym: "activation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie]
synonym: "activation of gamma-aminobutyric acid catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie]
synonym: "activation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of GABA catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of GABA catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of GABA catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of GABA catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of gamma-aminobutyric acid catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of GABA catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of GABA catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of gamma-aminobutyric acid catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of GABA catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of GABA catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of gamma-aminobutyric acid catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie]
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:0045764 ! positive regulation of cellular amino acid metabolic process
is_a: GO:1901715 ! regulation of gamma-aminobutyric acid catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009450 ! gamma-aminobutyric acid catabolic process
relationship: positively_regulates GO:0009450 ! gamma-aminobutyric acid catabolic process
created_by: maria.costanzo
creation_date: 2012-12-19T16:13:36Z

[Term]
id: GO:1901718
name: regulation of dipeptide transmembrane transport by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A regulation of transcription from RNA polymerase II promoter that results in regulation of dipeptide transmembrane transport." [GOC:TermGenie, GOC:vw]
is_a: GO:0035953 ! regulation of dipeptide transport by regulation of transcription from RNA polymerase II promoter
is_a: GO:2001148 ! regulation of dipeptide transmembrane transport
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: regulates GO:0100063 ! regulation of dipeptide transmembrane transport by transcription from RNA polymerase II promoter
relationship: regulates GO:0100063 ! regulation of dipeptide transmembrane transport by transcription from RNA polymerase II promoter
created_by: pr
creation_date: 2012-12-19T17:04:04Z

[Term]
id: GO:1901719
name: regulation of NMS complex assembly involved in kinetochore assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of NMS complex assembly involved in chromosome segregation." [GOC:TermGenie, PMID:22561345]
synonym: "regulation of KMN complex assembly involved in chromosome segregation" EXACT [GOC:TermGenie]
synonym: "regulation of KMN network assembly involved in chromosome segregation" EXACT [GOC:TermGenie]
synonym: "regulation of NMS complex association involved in chromosome segregation" EXACT [GOC:TermGenie]
is_a: GO:0090234 ! regulation of kinetochore assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044768 ! NMS complex assembly involved in kinetochore assembly
relationship: regulates GO:0044768 ! NMS complex assembly involved in kinetochore assembly
created_by: jl
creation_date: 2012-12-20T11:44:17Z

[Term]
id: GO:1901720
name: negative regulation of NMS complex assembly involved in kinetochore assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of NMS complex assembly involved in chromosome segregation." [GOC:TermGenie, PMID:22561345]
synonym: "down regulation of KMN complex assembly involved in chromosome segregation" EXACT [GOC:TermGenie]
synonym: "down regulation of KMN network assembly involved in chromosome segregation" EXACT [GOC:TermGenie]
synonym: "down regulation of NMS complex association involved in chromosome segregation" EXACT [GOC:TermGenie]
synonym: "down regulation of NMS complex interaction involved in chromosome segregation" EXACT [GOC:TermGenie]
synonym: "down-regulation of KMN complex interaction involved in chromosome segregation" EXACT [GOC:TermGenie]
synonym: "down-regulation of KMN network assembly involved in chromosome segregation" EXACT [GOC:TermGenie]
synonym: "down-regulation of NMS complex association involved in chromosome segregation" EXACT [GOC:TermGenie]
synonym: "down-regulation of NMS complex interaction involved in chromosome segregation" EXACT [GOC:TermGenie]
synonym: "downregulation of KMN complex interaction involved in chromosome segregation" EXACT [GOC:TermGenie]
synonym: "downregulation of KMN network assembly involved in chromosome segregation" EXACT [GOC:TermGenie]
synonym: "downregulation of NMS complex association involved in chromosome segregation" EXACT [GOC:TermGenie]
synonym: "downregulation of NMS complex interaction involved in chromosome segregation" EXACT [GOC:TermGenie]
synonym: "inhibition of KMN complex interaction involved in chromosome segregation" EXACT [GOC:TermGenie]
synonym: "inhibition of KMN network assembly involved in chromosome segregation" EXACT [GOC:TermGenie]
synonym: "inhibition of NMS complex association involved in chromosome segregation" EXACT [GOC:TermGenie]
synonym: "inhibition of NMS complex interaction involved in chromosome segregation" NARROW [GOC:TermGenie]
synonym: "negative regulation of KMN complex interaction involved in chromosome segregation" EXACT [GOC:TermGenie]
synonym: "negative regulation of KMN network assembly involved in chromosome segregation" EXACT [GOC:TermGenie]
synonym: "negative regulation of NMS complex association involved in chromosome segregation" EXACT [GOC:TermGenie]
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0031333 ! negative regulation of protein complex assembly
is_a: GO:0051985 ! negative regulation of chromosome segregation
is_a: GO:1901719 ! regulation of NMS complex assembly involved in kinetochore assembly
is_a: GO:1902116 ! negative regulation of organelle assembly
is_a: GO:2001251 ! negative regulation of chromosome organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044768 ! NMS complex assembly involved in kinetochore assembly
relationship: negatively_regulates GO:0044768 ! NMS complex assembly involved in kinetochore assembly
created_by: jl
creation_date: 2012-12-20T11:44:22Z

[Term]
id: GO:1901721
name: positive regulation of NMS complex assembly involved in kinetochore assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of NMS complex assembly involved in chromosome segregation." [GOC:TermGenie, PMID:22561345]
synonym: "activation of KMN complex assembly involved in chromosome segregation" EXACT [GOC:TermGenie]
synonym: "activation of KMN network assembly involved in chromosome segregation" EXACT [GOC:TermGenie]
synonym: "activation of NMS complex association involved in chromosome segregation" EXACT [GOC:TermGenie]
synonym: "activation of NMS complex interaction involved in chromosome segregation" NARROW [GOC:TermGenie]
synonym: "positive regulation of KMN complex interaction involved in chromosome segregation" EXACT [GOC:TermGenie]
synonym: "positive regulation of KMN network assembly involved in chromosome segregation" EXACT [GOC:TermGenie]
synonym: "positive regulation of NMS complex association involved in chromosome segregation" EXACT [GOC:TermGenie]
synonym: "up regulation of KMN complex interaction involved in chromosome segregation" EXACT [GOC:TermGenie]
synonym: "up regulation of KMN network assembly involved in chromosome segregation" EXACT [GOC:TermGenie]
synonym: "up regulation of NMS complex association involved in chromosome segregation" EXACT [GOC:TermGenie]
synonym: "up regulation of NMS complex interaction involved in chromosome segregation" EXACT [GOC:TermGenie]
synonym: "up-regulation of KMN complex interaction involved in chromosome segregation" EXACT [GOC:TermGenie]
synonym: "up-regulation of KMN network assembly involved in chromosome segregation" EXACT [GOC:TermGenie]
synonym: "up-regulation of NMS complex association involved in chromosome segregation" EXACT [GOC:TermGenie]
synonym: "up-regulation of NMS complex interaction involved in chromosome segregation" EXACT [GOC:TermGenie]
synonym: "upregulation of KMN complex interaction involved in chromosome segregation" EXACT [GOC:TermGenie]
synonym: "upregulation of KMN network assembly involved in chromosome segregation" EXACT [GOC:TermGenie]
synonym: "upregulation of NMS complex association involved in chromosome segregation" EXACT [GOC:TermGenie]
synonym: "upregulation of NMS complex interaction involved in chromosome segregation" EXACT [GOC:TermGenie]
is_a: GO:0031334 ! positive regulation of protein complex assembly
is_a: GO:0051984 ! positive regulation of chromosome segregation
is_a: GO:0090068 ! positive regulation of cell cycle process
is_a: GO:1901719 ! regulation of NMS complex assembly involved in kinetochore assembly
is_a: GO:1902117 ! positive regulation of organelle assembly
is_a: GO:2001252 ! positive regulation of chromosome organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044768 ! NMS complex assembly involved in kinetochore assembly
relationship: positively_regulates GO:0044768 ! NMS complex assembly involved in kinetochore assembly
created_by: jl
creation_date: 2012-12-20T11:44:26Z

[Term]
id: GO:1901722
name: regulation of cell proliferation involved in kidney development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell proliferation involved in kidney development." [GOC:TermGenie, PMID:18182616]
is_a: GO:0042127 ! regulation of cell proliferation
is_a: GO:0090183 ! regulation of kidney development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072111 ! cell proliferation involved in kidney development
relationship: regulates GO:0072111 ! cell proliferation involved in kidney development
created_by: krc
creation_date: 2012-12-27T19:30:31Z

[Term]
id: GO:1901723
name: negative regulation of cell proliferation involved in kidney development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation involved in kidney development." [GOC:TermGenie, PMID:18182616]
synonym: "down regulation of cell proliferation involved in kidney development" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell proliferation involved in kidney development" EXACT [GOC:TermGenie]
synonym: "downregulation of cell proliferation involved in kidney development" EXACT [GOC:TermGenie]
synonym: "inhibition of cell proliferation involved in kidney development" NARROW [GOC:TermGenie]
is_a: GO:0008285 ! negative regulation of cell proliferation
is_a: GO:0090185 ! negative regulation of kidney development
is_a: GO:1901722 ! regulation of cell proliferation involved in kidney development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072111 ! cell proliferation involved in kidney development
relationship: negatively_regulates GO:0072111 ! cell proliferation involved in kidney development
created_by: krc
creation_date: 2012-12-27T19:30:35Z

[Term]
id: GO:1901724
name: positive regulation of cell proliferation involved in kidney development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in kidney development." [GOC:TermGenie, PMID:18182616]
synonym: "activation of cell proliferation involved in kidney development" NARROW [GOC:TermGenie]
synonym: "up regulation of cell proliferation involved in kidney development" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell proliferation involved in kidney development" EXACT [GOC:TermGenie]
synonym: "upregulation of cell proliferation involved in kidney development" EXACT [GOC:TermGenie]
is_a: GO:0008284 ! positive regulation of cell proliferation
is_a: GO:0090184 ! positive regulation of kidney development
is_a: GO:1901722 ! regulation of cell proliferation involved in kidney development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072111 ! cell proliferation involved in kidney development
relationship: positively_regulates GO:0072111 ! cell proliferation involved in kidney development
created_by: krc
creation_date: 2012-12-27T19:30:40Z

[Term]
id: GO:1901725
name: regulation of histone deacetylase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of histone deacetylase activity." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20497126]
is_a: GO:0031063 ! regulation of histone deacetylation
is_a: GO:0051336 ! regulation of hydrolase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004407 ! histone deacetylase activity
relationship: regulates GO:0004407 ! histone deacetylase activity
created_by: rl
creation_date: 2013-01-07T09:14:12Z

[Term]
id: GO:1901726
name: negative regulation of histone deacetylase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone deacetylase activity." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20497126]
synonym: "down regulation of histone deacetylase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of histone deacetylase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of histone deacetylase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of histone deacetylase activity" NARROW [GOC:TermGenie]
is_a: GO:0031064 ! negative regulation of histone deacetylation
is_a: GO:0051346 ! negative regulation of hydrolase activity
is_a: GO:1901725 ! regulation of histone deacetylase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004407 ! histone deacetylase activity
relationship: negatively_regulates GO:0004407 ! histone deacetylase activity
created_by: rl
creation_date: 2013-01-07T09:14:17Z

[Term]
id: GO:1901727
name: positive regulation of histone deacetylase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of histone deacetylase activity." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20497126]
synonym: "activation of histone deacetylase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of histone deacetylase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of histone deacetylase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of histone deacetylase activity" EXACT [GOC:TermGenie]
is_a: GO:0031065 ! positive regulation of histone deacetylation
is_a: GO:0090045 ! positive regulation of deacetylase activity
is_a: GO:1901725 ! regulation of histone deacetylase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004407 ! histone deacetylase activity
relationship: positively_regulates GO:0004407 ! histone deacetylase activity
created_by: rl
creation_date: 2013-01-07T09:14:21Z

[Term]
id: GO:1901728
name: monensin A metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving monensin A." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00178]
synonym: "monensin A metabolism" EXACT [GOC:TermGenie]
synonym: "monensin metabolism" EXACT [GOC:yaf]
is_a: GO:0006066 ! alcohol metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
created_by: yaf
creation_date: 2013-01-09T11:55:45Z

[Term]
id: GO:1901729
name: monensin A catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of monensin A." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00178]
synonym: "monensin A breakdown" EXACT [GOC:TermGenie]
synonym: "monensin A catabolism" EXACT [GOC:TermGenie]
synonym: "monensin A degradation" EXACT [GOC:TermGenie]
synonym: "monensin breakdown" EXACT [GOC:yaf]
synonym: "monensin catabolism" EXACT [GOC:yaf]
synonym: "monensin degradation" EXACT [GOC:yaf]
is_a: GO:0046164 ! alcohol catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901728 ! monensin A metabolic process
created_by: yaf
creation_date: 2013-01-09T11:55:49Z

[Term]
id: GO:1901730
name: monensin A biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of monensin A." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00178]
synonym: "monensin A anabolism" EXACT [GOC:TermGenie]
synonym: "monensin A biosynthesis" EXACT [GOC:TermGenie]
synonym: "monensin A formation" EXACT [GOC:TermGenie]
synonym: "monensin A synthesis" EXACT [GOC:TermGenie]
synonym: "monensin anabolism" EXACT [GOC:yaf]
synonym: "monensin biosynthesis" EXACT [GOC:yaf]
synonym: "monensin formation" EXACT [GOC:yaf]
synonym: "monensin synthesis" EXACT [GOC:yaf]
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0046165 ! alcohol biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901728 ! monensin A metabolic process
created_by: yaf
creation_date: 2013-01-09T11:55:53Z

[Term]
id: GO:1901731
name: positive regulation of platelet aggregation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules." [GOC:fj, GOC:TermGenie]
synonym: "activation of blood platelet aggregation" NARROW [GOC:TermGenie]
synonym: "activation of platelet aggregation" NARROW [GOC:TermGenie]
synonym: "activation of thrombocyte aggregation" RELATED [GOC:TermGenie]
synonym: "positive regulation of blood platelet aggregation" EXACT [GOC:TermGenie]
synonym: "positive regulation of thrombocyte aggregation" RELATED [GOC:TermGenie]
synonym: "up regulation of blood platelet aggregation" EXACT [GOC:TermGenie]
synonym: "up regulation of platelet aggregation" EXACT [GOC:TermGenie]
synonym: "up regulation of thrombocyte aggregation" RELATED [GOC:TermGenie]
synonym: "up-regulation of blood platelet aggregation" EXACT [GOC:TermGenie]
synonym: "up-regulation of platelet aggregation" EXACT [GOC:TermGenie]
synonym: "up-regulation of thrombocyte aggregation" RELATED [GOC:TermGenie]
synonym: "upregulation of blood platelet aggregation" EXACT [GOC:TermGenie]
synonym: "upregulation of platelet aggregation" EXACT [GOC:TermGenie]
synonym: "upregulation of thrombocyte aggregation" RELATED [GOC:TermGenie]
is_a: GO:0010572 ! positive regulation of platelet activation
is_a: GO:0034112 ! positive regulation of homotypic cell-cell adhesion
is_a: GO:0090330 ! regulation of platelet aggregation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070527 ! platelet aggregation
relationship: positively_regulates GO:0070527 ! platelet aggregation
created_by: pr
creation_date: 2013-01-10T13:25:39Z

[Term]
id: GO:1901732
name: quercetin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving quercetin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00724]
synonym: "quercetin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0051552 ! flavone metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process
created_by: yaf
creation_date: 2013-01-11T10:25:11Z

[Term]
id: GO:1901733
name: quercetin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of quercetin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00724]
synonym: "quercetin breakdown" EXACT [GOC:TermGenie]
synonym: "quercetin catabolism" EXACT [GOC:TermGenie]
synonym: "quercetin degradation" EXACT [GOC:TermGenie]
is_a: GO:0044712 ! single-organism catabolic process
is_a: GO:0046275 ! flavonoid catabolic process
is_a: GO:1901616 ! organic hydroxy compound catabolic process
is_a: GO:1901732 ! quercetin metabolic process
created_by: yaf
creation_date: 2013-01-11T10:25:15Z

[Term]
id: GO:1901734
name: quercetin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of quercetin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00724]
synonym: "quercetin anabolism" EXACT [GOC:TermGenie]
synonym: "quercetin biosynthesis" EXACT [GOC:TermGenie]
synonym: "quercetin formation" EXACT [GOC:TermGenie]
synonym: "quercetin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0051553 ! flavone biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process
is_a: GO:1901732 ! quercetin metabolic process
created_by: yaf
creation_date: 2013-01-11T10:25:20Z

[Term]
id: GO:1901735
name: (R)-mevalonic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (R)-mevalonic acid." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00058]
synonym: "(R) mevalonate metabolism" EXACT [GOC:yaf]
synonym: "(R)-mevalonic acid metabolism" EXACT [GOC:TermGenie]
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process
created_by: yaf
creation_date: 2013-01-11T11:25:50Z

[Term]
id: GO:1901736
name: (R)-mevalonic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of (R)-mevalonic acid." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00058]
synonym: "(R)-mevalonate breakdown" EXACT [MetaCyc:PWY-5074]
synonym: "(R)-mevalonate catabolism" EXACT [MetaCyc:PWY-5074]
synonym: "(R)-mevalonate degradation" EXACT [MetaCyc:PWY-5074]
synonym: "(R)-mevalonic acid breakdown" EXACT [GOC:TermGenie]
synonym: "(R)-mevalonic acid catabolism" EXACT [GOC:TermGenie]
synonym: "(R)-mevalonic acid degradation" EXACT [GOC:TermGenie]
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:1901616 ! organic hydroxy compound catabolic process
is_a: GO:1901735 ! (R)-mevalonic acid metabolic process
created_by: yaf
creation_date: 2013-01-11T11:25:55Z

[Term]
id: GO:1901737
name: (R)-mevalonic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (R)-mevalonic acid." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00058]
synonym: "(R)-mevalonate anabolism" EXACT [GOC:yaf]
synonym: "(R)-mevalonate biosynthesis" EXACT [GOC:yaf]
synonym: "(R)-mevalonate synthesis" EXACT [GOC:yaf]
synonym: "(R)-mevalonic acid anabolism" EXACT [GOC:TermGenie]
synonym: "(R)-mevalonic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "(R)-mevalonic acid formation" EXACT [GOC:TermGenie]
synonym: "(R)-mevalonic acid synthesis" EXACT [GOC:TermGenie]
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process
is_a: GO:1901735 ! (R)-mevalonic acid metabolic process
created_by: yaf
creation_date: 2013-01-11T11:25:59Z

[Term]
id: GO:1901738
name: regulation of vitamin A metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vitamin A metabolic process." [GOC:TermGenie, PMID:18093975]
synonym: "regulation of vitamin A metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019747 ! regulation of isoprenoid metabolic process
is_a: GO:0030656 ! regulation of vitamin metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006776 ! vitamin A metabolic process
relationship: regulates GO:0006776 ! vitamin A metabolic process
created_by: dph
creation_date: 2013-01-11T15:29:43Z

[Term]
id: GO:1901739
name: regulation of myoblast fusion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of myoblast fusion." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21364645]
is_a: GO:0010830 ! regulation of myotube differentiation
is_a: GO:0060142 ! regulation of syncytium formation by plasma membrane fusion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007520 ! myoblast fusion
relationship: regulates GO:0007520 ! myoblast fusion
created_by: rl
creation_date: 2013-01-11T20:23:50Z

[Term]
id: GO:1901740
name: negative regulation of myoblast fusion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of myoblast fusion." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21364645]
synonym: "down regulation of myoblast fusion" EXACT [GOC:TermGenie]
synonym: "down-regulation of myoblast fusion" EXACT [GOC:TermGenie]
synonym: "downregulation of myoblast fusion" EXACT [GOC:TermGenie]
synonym: "inhibition of myoblast fusion" NARROW [GOC:TermGenie]
is_a: GO:0010832 ! negative regulation of myotube differentiation
is_a: GO:0034242 ! negative regulation of syncytium formation by plasma membrane fusion
is_a: GO:1901739 ! regulation of myoblast fusion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007520 ! myoblast fusion
relationship: negatively_regulates GO:0007520 ! myoblast fusion
created_by: rl
creation_date: 2013-01-11T20:23:55Z

[Term]
id: GO:1901741
name: positive regulation of myoblast fusion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of myoblast fusion." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21364645]
synonym: "activation of myoblast fusion" NARROW [GOC:TermGenie]
synonym: "up regulation of myoblast fusion" EXACT [GOC:TermGenie]
synonym: "up-regulation of myoblast fusion" EXACT [GOC:TermGenie]
synonym: "upregulation of myoblast fusion" EXACT [GOC:TermGenie]
is_a: GO:0010831 ! positive regulation of myotube differentiation
is_a: GO:0060143 ! positive regulation of syncytium formation by plasma membrane fusion
is_a: GO:1901739 ! regulation of myoblast fusion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007520 ! myoblast fusion
relationship: positively_regulates GO:0007520 ! myoblast fusion
created_by: rl
creation_date: 2013-01-11T20:24:03Z

[Term]
id: GO:1901742
name: 2-deoxystreptamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 2-deoxystreptamine." [GOC:TermGenie, GOC:yaf]
synonym: "2-deoxystreptamine metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019751 ! polyol metabolic process
is_a: GO:0097164 ! ammonium ion metabolic process
created_by: yaf
creation_date: 2013-01-14T10:01:57Z

[Term]
id: GO:1901743
name: 2-deoxystreptamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 2-deoxystreptamine." [GOC:TermGenie, GOC:yaf]
synonym: "2-deoxystreptamine breakdown" EXACT [GOC:TermGenie]
synonym: "2-deoxystreptamine catabolism" EXACT [GOC:TermGenie]
synonym: "2-deoxystreptamine degradation" EXACT [GOC:TermGenie]
is_a: GO:0046174 ! polyol catabolic process
is_a: GO:1901742 ! 2-deoxystreptamine metabolic process
created_by: yaf
creation_date: 2013-01-14T10:02:01Z

[Term]
id: GO:1901744
name: 2-deoxystreptamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 2-deoxystreptamine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00907]
synonym: "2-deoxystreptamine anabolism" EXACT [GOC:TermGenie]
synonym: "2-deoxystreptamine biosynthesis" EXACT [GOC:TermGenie]
synonym: "2-deoxystreptamine formation" EXACT [GOC:TermGenie]
synonym: "2-deoxystreptamine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046173 ! polyol biosynthetic process
is_a: GO:1901742 ! 2-deoxystreptamine metabolic process
created_by: yaf
creation_date: 2013-01-14T10:02:06Z

[Term]
id: GO:1901745
name: prephenate(2-) metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving prephenate(2-)." [GOC:TermGenie, GOC:yaf, PMID:16752890]
synonym: "prephenate metabolism" EXACT [GOC:yaf]
synonym: "prephenate(2-) metabolism" EXACT [GOC:TermGenie]
is_a: GO:0043648 ! dicarboxylic acid metabolic process
created_by: yaf
creation_date: 2013-01-14T10:13:49Z

[Term]
id: GO:1901746
name: prephenate(2-) catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of prephenate(2-)." [GOC:TermGenie, GOC:yaf, PMID:16752890]
synonym: "prephenate breakdown" EXACT [GOC:yaf]
synonym: "prephenate catabolism" EXACT [GOC:yaf]
synonym: "prephenate degradation" EXACT [GOC:yaf]
synonym: "prephenate(2-) breakdown" EXACT [GOC:TermGenie]
synonym: "prephenate(2-) catabolism" EXACT [GOC:TermGenie]
synonym: "prephenate(2-) degradation" EXACT [GOC:TermGenie]
is_a: GO:0043649 ! dicarboxylic acid catabolic process
is_a: GO:1901745 ! prephenate(2-) metabolic process
created_by: yaf
creation_date: 2013-01-14T10:13:53Z

[Term]
id: GO:1901747
name: prephenate(2-) biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of prephenate(2-)." [GOC:TermGenie, GOC:yaf, PMID:16752890, UniPathway:UPA00120]
synonym: "prephenate anabolism" EXACT [GOC:yaf]
synonym: "prephenate biosynthesis" EXACT [GOC:yaf]
synonym: "prephenate formation" EXACT [GOC:yaf]
synonym: "prephenate synthesis" EXACT [GOC:yaf]
synonym: "prephenate(2-) anabolism" EXACT [GOC:TermGenie]
synonym: "prephenate(2-) biosynthesis" EXACT [GOC:TermGenie]
synonym: "prephenate(2-) formation" EXACT [GOC:TermGenie]
synonym: "prephenate(2-) synthesis" EXACT [GOC:TermGenie]
is_a: GO:0043650 ! dicarboxylic acid biosynthetic process
is_a: GO:1901745 ! prephenate(2-) metabolic process
created_by: yaf
creation_date: 2013-01-14T10:13:57Z

[Term]
id: GO:1901748
name: leukotriene D4 metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving leukotriene D4." [GOC:TermGenie, GOC:yaf]
synonym: "leukotriene D4 metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006691 ! leukotriene metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process
created_by: yaf
creation_date: 2013-01-14T10:56:12Z

[Term]
id: GO:1901749
name: leukotriene D4 catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of leukotriene D4." [GOC:TermGenie, GOC:yaf]
synonym: "leukotriene D4 breakdown" EXACT [GOC:TermGenie]
synonym: "leukotriene D4 catabolism" EXACT [GOC:TermGenie]
synonym: "leukotriene D4 degradation" EXACT [GOC:TermGenie]
is_a: GO:0036100 ! leukotriene catabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:1901748 ! leukotriene D4 metabolic process
created_by: yaf
creation_date: 2013-01-14T10:56:17Z

[Term]
id: GO:1901750
name: leukotriene D4 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of leukotriene D4." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00880]
synonym: "leukotriene D4 anabolism" EXACT [GOC:TermGenie]
synonym: "leukotriene D4 biosynthesis" EXACT [GOC:TermGenie]
synonym: "leukotriene D4 formation" EXACT [GOC:TermGenie]
synonym: "leukotriene D4 synthesis" EXACT [GOC:TermGenie]
is_a: GO:0019370 ! leukotriene biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:1901748 ! leukotriene D4 metabolic process
created_by: yaf
creation_date: 2013-01-14T10:56:21Z

[Term]
id: GO:1901751
name: leukotriene A4 metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving leukotriene A4." [GOC:TermGenie, GOC:yaf]
synonym: "leukotriene A4 metabolism" EXACT [GOC:TermGenie]
is_a: GO:0001676 ! long-chain fatty acid metabolic process
is_a: GO:0006691 ! leukotriene metabolic process
is_a: GO:0031407 ! oxylipin metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
created_by: yaf
creation_date: 2013-01-14T11:04:56Z

[Term]
id: GO:1901752
name: leukotriene A4 catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of leukotriene A4." [GOC:TermGenie, GOC:yaf]
synonym: "leukotriene A4 breakdown" EXACT [GOC:TermGenie]
synonym: "leukotriene A4 catabolism" EXACT [GOC:TermGenie]
synonym: "leukotriene A4 degradation" EXACT [GOC:TermGenie]
is_a: GO:0036100 ! leukotriene catabolic process
is_a: GO:0042758 ! long-chain fatty acid catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1901751 ! leukotriene A4 metabolic process
created_by: yaf
creation_date: 2013-01-14T11:05:04Z

[Term]
id: GO:1901753
name: leukotriene A4 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of leukotriene A4." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00877]
synonym: "leukotriene A4 anabolism" EXACT [GOC:TermGenie]
synonym: "leukotriene A4 biosynthesis" EXACT [GOC:TermGenie]
synonym: "leukotriene A4 formation" EXACT [GOC:TermGenie]
synonym: "leukotriene A4 synthesis" EXACT [GOC:TermGenie]
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0019370 ! leukotriene biosynthetic process
is_a: GO:0031408 ! oxylipin biosynthetic process
is_a: GO:0042759 ! long-chain fatty acid biosynthetic process
is_a: GO:1901751 ! leukotriene A4 metabolic process
created_by: yaf
creation_date: 2013-01-14T11:05:09Z

[Term]
id: GO:1901754
name: vitamin D3 catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of vitamin D3." [GOC:TermGenie, GOC:yaf]
synonym: "calciol breakdown" EXACT [GOC:TermGenie]
synonym: "calciol catabolic process" EXACT [GOC:pr]
synonym: "calciol catabolism" EXACT [GOC:TermGenie]
synonym: "calciol degradation" EXACT [GOC:TermGenie]
synonym: "cholecalciferol catabolic process" EXACT [GOC:pr]
synonym: "cholecalciferol catabolism" EXACT [GOC:pr]
synonym: "vitamin D3 breakdown" EXACT [GOC:yaf]
synonym: "vitamin D3 catabolism" EXACT [GOC:yaf]
synonym: "vitamin D3 degradation" EXACT [GOC:yaf]
is_a: GO:0042369 ! vitamin D catabolic process
is_a: GO:0070640 ! vitamin D3 metabolic process
created_by: yaf
creation_date: 2013-01-14T11:11:04Z

[Term]
id: GO:1901755
name: vitamin D3 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of vitamin D3." [GOC:TermGenie, GOC:yaf, Unipathway:UPA00955]
synonym: "calciol anabolism" EXACT [GOC:TermGenie]
synonym: "calciol biosynthesis" EXACT [GOC:TermGenie]
synonym: "calciol biosynthetic process" EXACT [GOC:pr]
synonym: "calciol formation" EXACT [GOC:TermGenie]
synonym: "calciol synthesis" EXACT [GOC:TermGenie]
synonym: "cholecalciferol biosynthesis" EXACT [GOC:pr]
synonym: "cholecalciferol biosynthetic process" EXACT [GOC:pr]
synonym: "vitamin D3 anabolism" EXACT [GOC:yaf]
synonym: "vitamin D3 biosynthesis" EXACT [GOC:yaf]
synonym: "vitamin D3 formation" EXACT [GOC:yaf]
synonym: "vitamin D3 synthesis" EXACT [GOC:yaf]
is_a: GO:0042368 ! vitamin D biosynthetic process
is_a: GO:0070640 ! vitamin D3 metabolic process
is_a: GO:1902653 ! secondary alcohol biosynthetic process
created_by: yaf
creation_date: 2013-01-14T11:11:09Z

[Term]
id: GO:1901756
name: butirosin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving butirosin." [GOC:TermGenie, GOC:yaf]
synonym: "butirosin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0016137 ! glycoside metabolic process
is_a: GO:0019751 ! polyol metabolic process
created_by: yaf
creation_date: 2013-01-14T11:36:18Z

[Term]
id: GO:1901757
name: butirosin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of butirosin." [GOC:TermGenie, GOC:yaf]
synonym: "butirosin breakdown" EXACT [GOC:TermGenie]
synonym: "butirosin catabolism" EXACT [GOC:TermGenie]
synonym: "butirosin degradation" EXACT [GOC:TermGenie]
is_a: GO:0016139 ! glycoside catabolic process
is_a: GO:0046174 ! polyol catabolic process
is_a: GO:1901756 ! butirosin metabolic process
created_by: yaf
creation_date: 2013-01-14T11:36:22Z

[Term]
id: GO:1901758
name: butirosin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of butirosin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00964]
synonym: "butirosin anabolism" EXACT [GOC:TermGenie]
synonym: "butirosin biosynthesis" EXACT [GOC:TermGenie]
synonym: "butirosin formation" EXACT [GOC:TermGenie]
synonym: "butirosin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0016138 ! glycoside biosynthetic process
is_a: GO:0046173 ! polyol biosynthetic process
is_a: GO:1901756 ! butirosin metabolic process
created_by: yaf
creation_date: 2013-01-14T11:36:27Z

[Term]
id: GO:1901759
name: beta-L-Ara4N-lipid A metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving beta-L-Ara4N-lipid A." [GOC:TermGenie, GOC:yaf, PMID:17928292, PMID:19166326]
synonym: "4-amino-4-deoxy-beta-L-arabinose-lipid A metabolic process" EXACT []
synonym: "4-amino-4-deoxy-beta-L-arabinose-lipid A metabolism" EXACT []
synonym: "beta-L-Ara4N-lipid A metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006644 ! phospholipid metabolic process
is_a: GO:0006664 ! glycolipid metabolic process
is_a: GO:1901269 ! lipooligosaccharide metabolic process
created_by: pr
creation_date: 2013-01-14T12:52:57Z

[Term]
id: GO:1901760
name: beta-L-Ara4N-lipid A biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of beta-L-Ara4N-lipid A which occurs as a result of modification of the lipid A moiety of lipopolysaccharide by the addition of the sugar 4-amino-4-deoxy-L-arabinose (L-Ara4N). This strategy is adopted by pathogenic Gram-negative bacteria to evade cationic antimicrobial peptides produced by the innate immune system." [GOC:TermGenie, GOC:yaf, PMID:17928292, PMID:19166326, UniPathway:UPA00037]
synonym: "4-amino-4-deoxy-beta-L-arabinose-lipid A biosynthesis" EXACT []
synonym: "4-amino-4-deoxy-beta-L-arabinose-lipid A biosynthetic process" EXACT []
synonym: "beta-L-Ara4N-lipid A anabolism" EXACT [GOC:TermGenie]
synonym: "beta-L-Ara4N-lipid A biosynthesis" EXACT [GOC:TermGenie]
synonym: "beta-L-Ara4N-lipid A formation" EXACT [GOC:TermGenie]
synonym: "beta-L-Ara4N-lipid A synthesis" EXACT [GOC:TermGenie]
is_a: GO:0008654 ! phospholipid biosynthetic process
is_a: GO:0009247 ! glycolipid biosynthetic process
is_a: GO:1901271 ! lipooligosaccharide biosynthetic process
is_a: GO:1901759 ! beta-L-Ara4N-lipid A metabolic process
created_by: pr
creation_date: 2013-01-14T12:53:01Z

[Term]
id: GO:1901761
name: oxytetracycline metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving oxytetracycline." [GOC:TermGenie, GOC:yaf, PMID:8163168]
synonym: "oxytetracycline metabolism" EXACT [GOC:TermGenie]
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0030638 ! polyketide metabolic process
is_a: GO:0044763 ! single-organism cellular process
created_by: yaf
creation_date: 2013-01-15T09:52:50Z

[Term]
id: GO:1901762
name: oxytetracycline catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of oxytetracycline." [GOC:TermGenie, GOC:yaf, PMID:8163168]
synonym: "oxytetracycline breakdown" EXACT [GOC:TermGenie]
synonym: "oxytetracycline catabolism" EXACT [GOC:TermGenie]
synonym: "oxytetracycline degradation" EXACT [GOC:TermGenie]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0030640 ! polyketide catabolic process
is_a: GO:1901761 ! oxytetracycline metabolic process
created_by: yaf
creation_date: 2013-01-15T09:52:55Z

[Term]
id: GO:1901763
name: oxytetracycline biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of oxytetracycline." [GOC:TermGenie, GOC:yaf, PMID:8163168, UniPathway:UPA00926]
synonym: "oxytetracycline anabolism" EXACT [GOC:TermGenie]
synonym: "oxytetracycline biosynthesis" EXACT [GOC:TermGenie]
synonym: "oxytetracycline formation" EXACT [GOC:TermGenie]
synonym: "oxytetracycline synthesis" EXACT [GOC:TermGenie]
is_a: GO:0030639 ! polyketide biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:1901761 ! oxytetracycline metabolic process
created_by: yaf
creation_date: 2013-01-15T09:52:59Z

[Term]
id: GO:1901764
name: phosphinothricin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phosphinothricin." [GOC:TermGenie, GOC:yaf]
synonym: "phosphinothricin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006793 ! phosphorus metabolic process
is_a: GO:0071704 ! organic substance metabolic process
created_by: yaf
creation_date: 2013-01-15T10:02:37Z

[Term]
id: GO:1901765
name: phosphinothricin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phosphinothricin." [GOC:TermGenie, GOC:yaf]
synonym: "phosphinothricin breakdown" EXACT [GOC:TermGenie]
synonym: "phosphinothricin catabolism" EXACT [GOC:TermGenie]
synonym: "phosphinothricin degradation" EXACT [GOC:TermGenie]
is_a: GO:1901575 ! organic substance catabolic process
is_a: GO:1901764 ! phosphinothricin metabolic process
created_by: yaf
creation_date: 2013-01-15T10:02:42Z

[Term]
id: GO:1901766
name: phosphinothricin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phosphinothricin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00168]
synonym: "phosphinothricin anabolism" EXACT [GOC:TermGenie]
synonym: "phosphinothricin biosynthesis" EXACT [GOC:TermGenie]
synonym: "phosphinothricin formation" EXACT [GOC:TermGenie]
synonym: "phosphinothricin synthesis" EXACT [GOC:TermGenie]
is_a: GO:1901576 ! organic substance biosynthetic process
is_a: GO:1901764 ! phosphinothricin metabolic process
created_by: yaf
creation_date: 2013-01-15T10:02:46Z

[Term]
id: GO:1901767
name: carbapenem metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving carbapenem." [GOC:TermGenie, GOC:yaf, PMID:9402024]
synonym: "carbapenem metabolism" EXACT [GOC:TermGenie]
is_a: GO:0030653 ! beta-lactam antibiotic metabolic process
created_by: yaf
creation_date: 2013-01-15T10:08:57Z

[Term]
id: GO:1901768
name: carbapenem catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of carbapenem." [GOC:TermGenie, GOC:yaf, PMID:9402024]
synonym: "carbapenem breakdown" EXACT [GOC:TermGenie]
synonym: "carbapenem catabolism" EXACT [GOC:TermGenie]
synonym: "carbapenem degradation" EXACT [GOC:TermGenie]
is_a: GO:0030655 ! beta-lactam antibiotic catabolic process
is_a: GO:1901767 ! carbapenem metabolic process
created_by: yaf
creation_date: 2013-01-15T10:09:02Z

[Term]
id: GO:1901769
name: carbapenem biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of carbapenem." [GOC:TermGenie, GOC:yaf, PMID:9402024, UniPathway:UPA00182]
synonym: "carbapenem anabolism" EXACT [GOC:TermGenie]
synonym: "carbapenem biosynthesis" EXACT [GOC:TermGenie]
synonym: "carbapenem formation" EXACT [GOC:TermGenie]
synonym: "carbapenem synthesis" EXACT [GOC:TermGenie]
is_a: GO:0030654 ! beta-lactam antibiotic biosynthetic process
is_a: GO:1901767 ! carbapenem metabolic process
created_by: yaf
creation_date: 2013-01-15T10:09:06Z

[Term]
id: GO:1901770
name: daunorubicin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of daunorubicin." [GOC:TermGenie, GOC:yaf, PMID:7601857]
synonym: "daunorubicin breakdown" EXACT [GOC:TermGenie]
synonym: "daunorubicin catabolism" EXACT [GOC:TermGenie]
synonym: "daunorubicin degradation" EXACT [GOC:TermGenie]
is_a: GO:0030640 ! polyketide catabolic process
is_a: GO:0030649 ! aminoglycoside antibiotic catabolic process
is_a: GO:0044597 ! daunorubicin metabolic process
is_a: GO:1901662 ! quinone catabolic process
created_by: yaf
creation_date: 2013-01-15T10:14:29Z

[Term]
id: GO:1901771
name: daunorubicin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of daunorubicin." [GOC:TermGenie, GOC:yaf, PMID:7601857, UniPathway:UPA00054]
synonym: "daunorubicin anabolism" EXACT [GOC:TermGenie]
synonym: "daunorubicin biosynthesis" EXACT [GOC:TermGenie]
synonym: "daunorubicin formation" EXACT [GOC:TermGenie]
synonym: "daunorubicin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0030639 ! polyketide biosynthetic process
is_a: GO:0030648 ! aminoglycoside antibiotic biosynthetic process
is_a: GO:0044597 ! daunorubicin metabolic process
is_a: GO:1901663 ! quinone biosynthetic process
created_by: yaf
creation_date: 2013-01-15T10:14:33Z

[Term]
id: GO:1901772
name: lincomycin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lincomycin." [GOC:TermGenie, GOC:yaf, PMID:8577249]
synonym: "lincomycin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006575 ! cellular modified amino acid metabolic process
is_a: GO:0016143 ! S-glycoside metabolic process
is_a: GO:0043603 ! cellular amide metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
created_by: yaf
creation_date: 2013-01-15T11:53:52Z

[Term]
id: GO:1901773
name: lincomycin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lincomycin." [GOC:TermGenie, GOC:yaf, PMID:8577249]
synonym: "lincomycin breakdown" EXACT [GOC:TermGenie]
synonym: "lincomycin catabolism" EXACT [GOC:TermGenie]
synonym: "lincomycin degradation" EXACT [GOC:TermGenie]
is_a: GO:0016145 ! S-glycoside catabolic process
is_a: GO:0042219 ! cellular modified amino acid catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901772 ! lincomycin metabolic process
created_by: yaf
creation_date: 2013-01-15T11:53:57Z

[Term]
id: GO:1901774
name: lincomycin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lincomycin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6955, PMID:8577249, UniPathway:UPA00161]
synonym: "lincomycin anabolism" EXACT [GOC:TermGenie]
synonym: "lincomycin biosynthesis" EXACT [GOC:TermGenie]
synonym: "lincomycin formation" EXACT [GOC:TermGenie]
synonym: "lincomycin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0016144 ! S-glycoside biosynthetic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0042398 ! cellular modified amino acid biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901772 ! lincomycin metabolic process
created_by: yaf
creation_date: 2013-01-15T11:54:01Z

[Term]
id: GO:1901775
name: mitomycin C metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mitomycin C." [GOC:TermGenie, GOC:yaf, PMID:10094699, PMID:10099135]
synonym: "mitomycin C metabolism" EXACT [GOC:TermGenie]
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process
is_a: GO:1901661 ! quinone metabolic process
created_by: yaf
creation_date: 2013-01-15T12:11:48Z

[Term]
id: GO:1901776
name: mitomycin C catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of mitomycin C." [GOC:TermGenie, GOC:yaf, PMID:10094699, PMID:10099135]
synonym: "mitomycin C breakdown" EXACT [GOC:TermGenie]
synonym: "mitomycin C catabolism" EXACT [GOC:TermGenie]
synonym: "mitomycin C degradation" EXACT [GOC:TermGenie]
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process
is_a: GO:1901662 ! quinone catabolic process
is_a: GO:1901775 ! mitomycin C metabolic process
created_by: yaf
creation_date: 2013-01-15T12:11:52Z

[Term]
id: GO:1901777
name: mitomycin C biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of mitomycin C." [GOC:TermGenie, GOC:yaf, PMID:10094699, PMID:10099135, UniPathway:UPA00851]
synonym: "mitomycin C anabolism" EXACT [GOC:TermGenie]
synonym: "mitomycin C biosynthesis" EXACT [GOC:TermGenie]
synonym: "mitomycin C formation" EXACT [GOC:TermGenie]
synonym: "mitomycin C synthesis" EXACT [GOC:TermGenie]
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process
is_a: GO:1901663 ! quinone biosynthetic process
is_a: GO:1901775 ! mitomycin C metabolic process
created_by: yaf
creation_date: 2013-01-15T12:11:57Z

[Term]
id: GO:1901778
name: pentalenolactone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pentalenolactone." [GOC:TermGenie, GOC:yaf, PMID:17178094]
synonym: "pentalenolactone metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006714 ! sesquiterpenoid metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0097176 ! epoxide metabolic process
is_a: GO:1901334 ! lactone metabolic process
created_by: yaf
creation_date: 2013-01-16T09:49:38Z

[Term]
id: GO:1901779
name: pentalenolactone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pentalenolactone." [GOC:TermGenie, GOC:yaf, PMID:17178094]
synonym: "pentalenolactone breakdown" EXACT [GOC:TermGenie]
synonym: "pentalenolactone catabolism" EXACT [GOC:TermGenie]
synonym: "pentalenolactone degradation" EXACT [GOC:TermGenie]
is_a: GO:0016107 ! sesquiterpenoid catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:1901335 ! lactone catabolic process
is_a: GO:1901502 ! ether catabolic process
is_a: GO:1901778 ! pentalenolactone metabolic process
created_by: yaf
creation_date: 2013-01-16T09:49:42Z

[Term]
id: GO:1901780
name: pentalenolactone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pentalenolactone." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6915, PMID:17178094, UniPathway:UPA00974]
synonym: "pentalenolactone anabolism" EXACT [GOC:TermGenie]
synonym: "pentalenolactone biosynthesis" EXACT [GOC:TermGenie]
synonym: "pentalenolactone formation" EXACT [GOC:TermGenie]
synonym: "pentalenolactone synthesis" EXACT [GOC:TermGenie]
is_a: GO:0016106 ! sesquiterpenoid biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:1901336 ! lactone biosynthetic process
is_a: GO:1901503 ! ether biosynthetic process
is_a: GO:1901778 ! pentalenolactone metabolic process
created_by: yaf
creation_date: 2013-01-16T09:49:47Z

[Term]
id: GO:1901781
name: p-cumate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving p-cumate." [GOC:TermGenie, GOC:yaf, PMID:8631713]
synonym: "p-cumate metabolism" EXACT [GOC:TermGenie]
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process
created_by: yaf
creation_date: 2013-01-16T10:40:28Z

[Term]
id: GO:1901782
name: p-cumate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of p-cumate." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5273, PMID:8631713, UniPathway:UPA00937]
synonym: "p-cumate breakdown" EXACT [GOC:TermGenie]
synonym: "p-cumate catabolism" EXACT [GOC:TermGenie]
synonym: "p-cumate degradation" EXACT [GOC:TermGenie]
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901781 ! p-cumate metabolic process
created_by: yaf
creation_date: 2013-01-16T10:40:32Z

[Term]
id: GO:1901783
name: p-cumate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of p-cumate." [GOC:TermGenie, GOC:yaf, PMID:8631713]
synonym: "p-cumate anabolism" EXACT [GOC:TermGenie]
synonym: "p-cumate biosynthesis" EXACT [GOC:TermGenie]
synonym: "p-cumate formation" EXACT [GOC:TermGenie]
synonym: "p-cumate synthesis" EXACT [GOC:TermGenie]
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901781 ! p-cumate metabolic process
created_by: yaf
creation_date: 2013-01-16T10:40:36Z

[Term]
id: GO:1901784
name: p-cresol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving p-cresol." [GOC:TermGenie, GOC:yaf, PMID:10623531]
synonym: "p-cresol metabolism" EXACT [GOC:TermGenie]
is_a: GO:0042212 ! cresol metabolic process
created_by: yaf
creation_date: 2013-01-16T11:03:59Z

[Term]
id: GO:1901785
name: p-cresol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of p-cresol." [GOC:TermGenie, GOC:yaf, PMID:10623531, UniPathway:UPA00708]
synonym: "p-cresol breakdown" EXACT [GOC:TermGenie]
synonym: "p-cresol catabolism" EXACT [GOC:TermGenie]
synonym: "p-cresol degradation" EXACT [GOC:TermGenie]
is_a: GO:0046199 ! cresol catabolic process
is_a: GO:1901784 ! p-cresol metabolic process
created_by: yaf
creation_date: 2013-01-16T11:04:04Z

[Term]
id: GO:1901786
name: p-cresol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of p-cresol." [GOC:TermGenie, GOC:yaf, PMID:10623531]
synonym: "p-cresol anabolism" EXACT [GOC:TermGenie]
synonym: "p-cresol biosynthesis" EXACT [GOC:TermGenie]
synonym: "p-cresol formation" EXACT [GOC:TermGenie]
synonym: "p-cresol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:1901784 ! p-cresol metabolic process
created_by: yaf
creation_date: 2013-01-16T11:04:08Z

[Term]
id: GO:1901787
name: benzoyl-CoA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving benzoyl-CoA." [GOC:TermGenie, GOC:yaf]
synonym: "benzoyl-CoA metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006637 ! acyl-CoA metabolic process
created_by: yaf
creation_date: 2013-01-16T11:13:54Z

[Term]
id: GO:1901788
name: benzoyl-CoA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of benzoyl-CoA." [GOC:TermGenie, GOC:yaf, MetaCyc:CENTBENZCOA-PWY, MetaCyc:P321-PWY, MetaCyc:PWY-1361, UniPathway:UPA00739]
synonym: "benzoyl-CoA breakdown" EXACT [GOC:TermGenie]
synonym: "benzoyl-CoA catabolism" EXACT [GOC:TermGenie]
synonym: "benzoyl-CoA degradation" EXACT [GOC:TermGenie]
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:1901575 ! organic substance catabolic process
is_a: GO:1901787 ! benzoyl-CoA metabolic process
created_by: yaf
creation_date: 2013-01-16T11:13:59Z

[Term]
id: GO:1901789
name: benzoyl-CoA biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of benzoyl-CoA." [GOC:TermGenie, GOC:yaf]
synonym: "benzoyl-CoA anabolism" EXACT [GOC:TermGenie]
synonym: "benzoyl-CoA biosynthesis" EXACT [GOC:TermGenie]
synonym: "benzoyl-CoA formation" EXACT [GOC:TermGenie]
synonym: "benzoyl-CoA synthesis" EXACT [GOC:TermGenie]
is_a: GO:0071616 ! acyl-CoA biosynthetic process
is_a: GO:1901787 ! benzoyl-CoA metabolic process
created_by: yaf
creation_date: 2013-01-16T11:14:03Z

[Term]
id: GO:1901790
name: 3-(2,3-dihydroxyphenyl)propanoate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 3-(2,3-dihydroxyphenyl)propanoate." [GOC:TermGenie, GOC:yaf, MetaCyc:1.13.11.16-RXN, MetaCyc:HCAMHPDEG-PWY]
synonym: "3-(2,3-dihydroxyphenyl)propanoate metabolism" EXACT [GOC:TermGenie]
is_a: GO:0032787 ! monocarboxylic acid metabolic process
created_by: yaf
creation_date: 2013-01-16T11:40:57Z

[Term]
id: GO:1901791
name: 3-(2,3-dihydroxyphenyl)propanoate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 3-(2,3-dihydroxyphenyl)propanoate." [GOC:TermGenie, GOC:yaf, MetaCyc:1.13.11.16-RXN, MetaCyc:HCAMHPDEG-PWY, UniPathway:UPA00836]
synonym: "3-(2,3-dihydroxyphenyl)propanoate breakdown" EXACT [GOC:TermGenie]
synonym: "3-(2,3-dihydroxyphenyl)propanoate catabolism" EXACT [GOC:TermGenie]
synonym: "3-(2,3-dihydroxyphenyl)propanoate degradation" EXACT [GOC:TermGenie]
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:1901790 ! 3-(2,3-dihydroxyphenyl)propanoate metabolic process
created_by: yaf
creation_date: 2013-01-16T11:41:02Z

[Term]
id: GO:1901792
name: 3-(2,3-dihydroxyphenyl)propanoate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 3-(2,3-dihydroxyphenyl)propanoate." [GOC:TermGenie, GOC:yaf, MetaCyc:1.13.11.16-RXN, MetaCyc:HCAMHPDEG-PWY]
synonym: "3-(2,3-dihydroxyphenyl)propanoate anabolism" EXACT [GOC:TermGenie]
synonym: "3-(2,3-dihydroxyphenyl)propanoate biosynthesis" EXACT [GOC:TermGenie]
synonym: "3-(2,3-dihydroxyphenyl)propanoate formation" EXACT [GOC:TermGenie]
synonym: "3-(2,3-dihydroxyphenyl)propanoate synthesis" EXACT [GOC:TermGenie]
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:1901790 ! 3-(2,3-dihydroxyphenyl)propanoate metabolic process
created_by: yaf
creation_date: 2013-01-16T11:41:06Z

[Term]
id: GO:1901793
name: 3-(3-hydroxyphenyl)propanoate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 3-(3-hydroxyphenyl)propanoate." [GOC:TermGenie, GOC:yaf, PMID:10537203]
synonym: "3-(3-hydroxyphenyl)propanoate metabolism" EXACT [GOC:TermGenie]
is_a: GO:0032787 ! monocarboxylic acid metabolic process
created_by: yaf
creation_date: 2013-01-16T11:47:09Z

[Term]
id: GO:1901794
name: 3-(3-hydroxyphenyl)propanoate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 3-(3-hydroxyphenyl)propanoate." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY0-1277, PMID:10537203, UniPathway:UPA00835]
synonym: "3-(3-hydroxyphenyl)propanoate breakdown" EXACT [GOC:TermGenie]
synonym: "3-(3-hydroxyphenyl)propanoate catabolism" EXACT [GOC:TermGenie]
synonym: "3-(3-hydroxyphenyl)propanoate degradation" EXACT [GOC:TermGenie]
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:1901793 ! 3-(3-hydroxyphenyl)propanoate metabolic process
created_by: yaf
creation_date: 2013-01-16T11:47:17Z

[Term]
id: GO:1901795
name: 3-(3-hydroxyphenyl)propanoate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 3-(3-hydroxyphenyl)propanoate." [GOC:TermGenie, GOC:yaf, PMID:10537203]
synonym: "3-(3-hydroxyphenyl)propanoate anabolism" EXACT [GOC:TermGenie]
synonym: "3-(3-hydroxyphenyl)propanoate biosynthesis" EXACT [GOC:TermGenie]
synonym: "3-(3-hydroxyphenyl)propanoate formation" EXACT [GOC:TermGenie]
synonym: "3-(3-hydroxyphenyl)propanoate synthesis" EXACT [GOC:TermGenie]
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:1901793 ! 3-(3-hydroxyphenyl)propanoate metabolic process
created_by: yaf
creation_date: 2013-01-16T11:47:21Z

[Term]
id: GO:1901796
name: regulation of signal transduction by p53 class mediator
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator." [GOC:TermGenie]
is_a: GO:1902531 ! regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072331 ! signal transduction by p53 class mediator
relationship: regulates GO:0072331 ! signal transduction by p53 class mediator
created_by: hjd
creation_date: 2013-01-18T21:51:39Z

[Term]
id: GO:1901797
name: negative regulation of signal transduction by p53 class mediator
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction by p53 class mediator." [GOC:TermGenie]
synonym: "down regulation of signal transduction by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "down-regulation of signal transduction by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "downregulation of signal transduction by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "inhibition of signal transduction by p53 class mediator" NARROW [GOC:TermGenie]
is_a: GO:1901796 ! regulation of signal transduction by p53 class mediator
is_a: GO:1902532 ! negative regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072331 ! signal transduction by p53 class mediator
relationship: negatively_regulates GO:0072331 ! signal transduction by p53 class mediator
created_by: hjd
creation_date: 2013-01-18T21:51:44Z

[Term]
id: GO:1901798
name: positive regulation of signal transduction by p53 class mediator
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of signal transduction by p53 class mediator." [GOC:TermGenie]
synonym: "activation of signal transduction by p53 class mediator" NARROW [GOC:TermGenie]
synonym: "up regulation of signal transduction by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "up-regulation of signal transduction by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "upregulation of signal transduction by p53 class mediator" EXACT [GOC:TermGenie]
is_a: GO:1901796 ! regulation of signal transduction by p53 class mediator
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072331 ! signal transduction by p53 class mediator
relationship: positively_regulates GO:0072331 ! signal transduction by p53 class mediator
created_by: hjd
creation_date: 2013-01-18T21:51:48Z

[Term]
id: GO:1901799
name: negative regulation of proteasomal protein catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of proteasomal protein catabolic process." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21669198]
synonym: "down regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of proteasome-mediated protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of proteasome-mediated protein catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of proteasome-mediated protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of proteasome-mediated protein catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of proteasome-mediated protein catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of proteasome-mediated protein catabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of proteasomal protein catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of proteasome-mediated protein catabolic process" EXACT [GOC:TermGenie]
synonym: "inhibition of proteasome-mediated protein catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of proteasome-mediated protein catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of proteasome-mediated protein catabolism" EXACT [GOC:TermGenie]
is_a: GO:0061136 ! regulation of proteasomal protein catabolic process
is_a: GO:1903051 ! negative regulation of proteolysis involved in cellular protein catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010498 ! proteasomal protein catabolic process
relationship: negatively_regulates GO:0010498 ! proteasomal protein catabolic process
created_by: rl
creation_date: 2013-01-21T20:10:54Z

[Term]
id: GO:1901800
name: positive regulation of proteasomal protein catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of proteasomal protein catabolic process." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21669198]
synonym: "activation of proteasomal protein catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of proteasome-mediated protein catabolic process" EXACT [GOC:TermGenie]
synonym: "activation of proteasome-mediated protein catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of proteasome-mediated protein catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of proteasome-mediated protein catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of proteasome-mediated protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of proteasome-mediated protein catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of proteasome-mediated protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of proteasome-mediated protein catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of proteasome-mediated protein catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of proteasome-mediated protein catabolism" EXACT [GOC:TermGenie]
is_a: GO:0061136 ! regulation of proteasomal protein catabolic process
is_a: GO:1903052 ! positive regulation of proteolysis involved in cellular protein catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010498 ! proteasomal protein catabolic process
relationship: positively_regulates GO:0010498 ! proteasomal protein catabolic process
created_by: rl
creation_date: 2013-01-21T20:10:58Z

[Term]
id: GO:1901801
name: 1,5-anhydro-D-fructose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 1,5-anhydro-D-fructose." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6992, PMID:15716041, UniPathway:UPA00738]
synonym: "1,5-anhydro-D-fructose metabolism" EXACT [GOC:TermGenie]
is_a: GO:0005996 ! monosaccharide metabolic process
created_by: yaf
creation_date: 2013-01-22T09:56:20Z

[Term]
id: GO:1901802
name: 1,5-anhydro-D-fructose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 1,5-anhydro-D-fructose." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6992, PMID:15716041, UniPathway:UPA00738]
synonym: "1,5-anhydro-D-fructose breakdown" EXACT [GOC:TermGenie]
synonym: "1,5-anhydro-D-fructose catabolism" EXACT [GOC:TermGenie]
synonym: "1,5-anhydro-D-fructose degradation" EXACT [GOC:TermGenie]
is_a: GO:0046365 ! monosaccharide catabolic process
is_a: GO:1901801 ! 1,5-anhydro-D-fructose metabolic process
created_by: yaf
creation_date: 2013-01-22T09:56:25Z

[Term]
id: GO:1901803
name: 1,5-anhydro-D-fructose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 1,5-anhydro-D-fructose." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6992, PMID:15716041, UniPathway:UPA00738]
synonym: "1,5-anhydro-D-fructose anabolism" EXACT [GOC:TermGenie]
synonym: "1,5-anhydro-D-fructose biosynthesis" EXACT [GOC:TermGenie]
synonym: "1,5-anhydro-D-fructose formation" EXACT [GOC:TermGenie]
synonym: "1,5-anhydro-D-fructose synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046364 ! monosaccharide biosynthetic process
is_a: GO:1901801 ! 1,5-anhydro-D-fructose metabolic process
created_by: yaf
creation_date: 2013-01-22T09:56:34Z

[Term]
id: GO:1901804
name: beta-glucoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving beta-glucoside." [GOC:TermGenie, GOC:yaf, PMID:15205427, PMID:16390337, PMID:8990303, Unipathway:UPA00237]
synonym: "beta-glucoside metabolism" EXACT [GOC:TermGenie]
is_a: GO:0016137 ! glycoside metabolic process
created_by: yaf
creation_date: 2013-01-22T10:10:21Z

[Term]
id: GO:1901805
name: beta-glucoside catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of beta-glucoside." [GOC:TermGenie, GOC:yaf, PMID:15205427, PMID:16390337, PMID:8990303, Unipathway:UPA00237]
synonym: "beta-glucoside breakdown" EXACT [GOC:TermGenie]
synonym: "beta-glucoside catabolism" EXACT [GOC:TermGenie]
synonym: "beta-glucoside degradation" EXACT [GOC:TermGenie]
is_a: GO:0016139 ! glycoside catabolic process
is_a: GO:1901804 ! beta-glucoside metabolic process
created_by: yaf
creation_date: 2013-01-22T10:10:26Z

[Term]
id: GO:1901806
name: beta-glucoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of beta-glucoside." [GOC:TermGenie, GOC:yaf, PMID:15205427, PMID:16390337, PMID:8990303, Unipathway:UPA00237]
synonym: "beta-glucoside anabolism" EXACT [GOC:TermGenie]
synonym: "beta-glucoside biosynthesis" EXACT [GOC:TermGenie]
synonym: "beta-glucoside formation" EXACT [GOC:TermGenie]
synonym: "beta-glucoside synthesis" EXACT [GOC:TermGenie]
is_a: GO:0016138 ! glycoside biosynthetic process
is_a: GO:1901804 ! beta-glucoside metabolic process
created_by: yaf
creation_date: 2013-01-22T10:10:30Z

[Term]
id: GO:1901807
name: capsanthin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving capsanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5174, PMID:10995282, UniPathway:UPA00806]
synonym: "capsanthin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0016122 ! xanthophyll metabolic process
created_by: yaf
creation_date: 2013-01-22T10:21:39Z

[Term]
id: GO:1901808
name: capsanthin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of capsanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5174, PMID:10995282, UniPathway:UPA00806]
synonym: "capsanthin breakdown" EXACT [GOC:TermGenie]
synonym: "capsanthin catabolism" EXACT [GOC:TermGenie]
synonym: "capsanthin degradation" EXACT [GOC:TermGenie]
is_a: GO:0016124 ! xanthophyll catabolic process
is_a: GO:1901807 ! capsanthin metabolic process
created_by: yaf
creation_date: 2013-01-22T10:21:46Z

[Term]
id: GO:1901809
name: capsanthin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of capsanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5174, PMID:10995282, UniPathway:UPA00806]
synonym: "capsanthin anabolism" EXACT [GOC:TermGenie]
synonym: "capsanthin biosynthesis" EXACT [GOC:TermGenie]
synonym: "capsanthin formation" EXACT [GOC:TermGenie]
synonym: "capsanthin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0016123 ! xanthophyll biosynthetic process
is_a: GO:1901807 ! capsanthin metabolic process
created_by: yaf
creation_date: 2013-01-22T10:21:50Z

[Term]
id: GO:1901810
name: beta-carotene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving beta-carotene." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5943, PMID:11387982, UniPathway:UPA00802]
synonym: "beta-carotene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0016119 ! carotene metabolic process
created_by: yaf
creation_date: 2013-01-22T10:30:23Z

[Term]
id: GO:1901811
name: beta-carotene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of beta-carotene." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5943, PMID:11387982, UniPathway:UPA00802]
synonym: "beta-carotene breakdown" EXACT [GOC:TermGenie]
synonym: "beta-carotene catabolism" EXACT [GOC:TermGenie]
synonym: "beta-carotene degradation" EXACT [GOC:TermGenie]
is_a: GO:0016121 ! carotene catabolic process
is_a: GO:1901810 ! beta-carotene metabolic process
created_by: yaf
creation_date: 2013-01-22T10:30:28Z

[Term]
id: GO:1901812
name: beta-carotene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of beta-carotene." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5943, PMID:11387982, UniPathway:UPA00802]
synonym: "beta-carotene anabolism" EXACT [GOC:TermGenie]
synonym: "beta-carotene biosynthesis" EXACT [GOC:TermGenie]
synonym: "beta-carotene formation" EXACT [GOC:TermGenie]
synonym: "beta-carotene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0016120 ! carotene biosynthetic process
is_a: GO:1901810 ! beta-carotene metabolic process
created_by: yaf
creation_date: 2013-01-22T10:30:32Z

[Term]
id: GO:1901813
name: astaxanthin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving astaxanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5288, PMID:16434154, UniPathway:UPA00387]
synonym: "astaxanthin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0016122 ! xanthophyll metabolic process
created_by: yaf
creation_date: 2013-01-22T10:36:59Z

[Term]
id: GO:1901814
name: astaxanthin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of astaxanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5288, PMID:16434154, UniPathway:UPA00387]
synonym: "astaxanthin breakdown" EXACT [GOC:TermGenie]
synonym: "astaxanthin catabolism" EXACT [GOC:TermGenie]
synonym: "astaxanthin degradation" EXACT [GOC:TermGenie]
is_a: GO:0016124 ! xanthophyll catabolic process
is_a: GO:1901813 ! astaxanthin metabolic process
created_by: yaf
creation_date: 2013-01-22T10:37:03Z

[Term]
id: GO:1901815
name: astaxanthin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of astaxanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5288, PMID:16434154, UniPathway:UPA00387]
synonym: "astaxanthin anabolism" EXACT [GOC:TermGenie]
synonym: "astaxanthin biosynthesis" EXACT [GOC:TermGenie]
synonym: "astaxanthin formation" EXACT [GOC:TermGenie]
synonym: "astaxanthin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0016123 ! xanthophyll biosynthetic process
is_a: GO:1901813 ! astaxanthin metabolic process
created_by: yaf
creation_date: 2013-01-22T10:37:11Z

[Term]
id: GO:1901816
name: beta-zeacarotene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving beta-zeacarotene." [GOC:TermGenie, GOC:yaf, PMID:3710717, UniPathway:UPA00805]
synonym: "beta-zeacarotene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0016119 ! carotene metabolic process
created_by: yaf
creation_date: 2013-01-22T10:42:03Z

[Term]
id: GO:1901817
name: beta-zeacarotene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of beta-zeacarotene." [GOC:TermGenie, GOC:yaf, PMID:3710717, UniPathway:UPA00805]
synonym: "beta-zeacarotene breakdown" EXACT [GOC:TermGenie]
synonym: "beta-zeacarotene catabolism" EXACT [GOC:TermGenie]
synonym: "beta-zeacarotene degradation" EXACT [GOC:TermGenie]
is_a: GO:0016121 ! carotene catabolic process
is_a: GO:1901816 ! beta-zeacarotene metabolic process
created_by: yaf
creation_date: 2013-01-22T10:42:08Z

[Term]
id: GO:1901818
name: beta-zeacarotene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of beta-zeacarotene." [GOC:TermGenie, GOC:yaf, PMID:3710717, UniPathway:UPA00805]
synonym: "beta-zeacarotene anabolism" EXACT [GOC:TermGenie]
synonym: "beta-zeacarotene biosynthesis" EXACT [GOC:TermGenie]
synonym: "beta-zeacarotene formation" EXACT [GOC:TermGenie]
synonym: "beta-zeacarotene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0016120 ! carotene biosynthetic process
is_a: GO:1901816 ! beta-zeacarotene metabolic process
created_by: yaf
creation_date: 2013-01-22T10:42:12Z

[Term]
id: GO:1901819
name: alpha-zeacarotene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving alpha-zeacarotene." [GOC:TermGenie, GOC:yaf, PMID:6060456, UniPathway:UPA00804]
synonym: "alpha-zeacarotene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0016119 ! carotene metabolic process
created_by: yaf
creation_date: 2013-01-22T10:51:02Z

[Term]
id: GO:1901820
name: alpha-zeacarotene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of alpha-zeacarotene." [GOC:TermGenie, GOC:yaf, PMID:6060456, UniPathway:UPA00804]
synonym: "alpha-zeacarotene breakdown" EXACT [GOC:TermGenie]
synonym: "alpha-zeacarotene catabolism" EXACT [GOC:TermGenie]
synonym: "alpha-zeacarotene degradation" EXACT [GOC:TermGenie]
is_a: GO:0016121 ! carotene catabolic process
is_a: GO:1901819 ! alpha-zeacarotene metabolic process
created_by: yaf
creation_date: 2013-01-22T10:51:06Z

[Term]
id: GO:1901821
name: alpha-zeacarotene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of alpha-zeacarotene." [GOC:TermGenie, GOC:yaf, PMID:6060456, UniPathway:UPA00804]
synonym: "alpha-zeacarotene anabolism" EXACT [GOC:TermGenie]
synonym: "alpha-zeacarotene biosynthesis" EXACT [GOC:TermGenie]
synonym: "alpha-zeacarotene formation" EXACT [GOC:TermGenie]
synonym: "alpha-zeacarotene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0016120 ! carotene biosynthetic process
is_a: GO:1901819 ! alpha-zeacarotene metabolic process
created_by: yaf
creation_date: 2013-01-22T10:51:14Z

[Term]
id: GO:1901822
name: delta-carotene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving delta-carotene." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5946, PMID:8837512, UniPathway:UPA00801]
synonym: "delta-carotene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0016119 ! carotene metabolic process
created_by: yaf
creation_date: 2013-01-22T11:17:29Z

[Term]
id: GO:1901823
name: delta-carotene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of delta-carotene." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5946, PMID:8837512, UniPathway:UPA00801]
synonym: "delta-carotene breakdown" EXACT [GOC:TermGenie]
synonym: "delta-carotene catabolism" EXACT [GOC:TermGenie]
synonym: "delta-carotene degradation" EXACT [GOC:TermGenie]
is_a: GO:0016121 ! carotene catabolic process
is_a: GO:1901822 ! delta-carotene metabolic process
created_by: yaf
creation_date: 2013-01-22T11:17:34Z

[Term]
id: GO:1901824
name: delta-carotene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of delta-carotene." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5946, PMID:8837512, UniPathway:UPA00801]
synonym: "delta-carotene anabolism" EXACT [GOC:TermGenie]
synonym: "delta-carotene biosynthesis" EXACT [GOC:TermGenie]
synonym: "delta-carotene formation" EXACT [GOC:TermGenie]
synonym: "delta-carotene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0016120 ! carotene biosynthetic process
is_a: GO:1901822 ! delta-carotene metabolic process
created_by: yaf
creation_date: 2013-01-22T11:17:38Z

[Term]
id: GO:1901825
name: zeaxanthin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving zeaxanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5944, UniPathway:UPA00843]
synonym: "zeaxanthin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0016122 ! xanthophyll metabolic process
created_by: yaf
creation_date: 2013-01-22T11:36:55Z

[Term]
id: GO:1901826
name: zeaxanthin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of zeaxanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5944, UniPathway:UPA00843]
synonym: "zeaxanthin breakdown" EXACT [GOC:TermGenie]
synonym: "zeaxanthin catabolism" EXACT [GOC:TermGenie]
synonym: "zeaxanthin degradation" EXACT [GOC:TermGenie]
is_a: GO:0016124 ! xanthophyll catabolic process
is_a: GO:1901825 ! zeaxanthin metabolic process
created_by: yaf
creation_date: 2013-01-22T11:37:00Z

[Term]
id: GO:1901827
name: zeaxanthin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of zeaxanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5944, UniPathway:UPA00843]
synonym: "zeaxanthin anabolism" EXACT [GOC:TermGenie]
synonym: "zeaxanthin biosynthesis" EXACT [GOC:TermGenie]
synonym: "zeaxanthin formation" EXACT [GOC:TermGenie]
synonym: "zeaxanthin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0016123 ! xanthophyll biosynthetic process
is_a: GO:1901825 ! zeaxanthin metabolic process
created_by: yaf
creation_date: 2013-01-22T11:37:07Z

[Term]
id: GO:1901828
name: zeaxanthin bis(beta-D-glucoside) metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving zeaxanthin bis(beta-D-glucoside)." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6288, PMID:20075616, UniPathway:UPA00798]
synonym: "zeaxanthin bis(beta-D-glucoside) metabolism" EXACT [GOC:TermGenie]
synonym: "zeaxanthin diglucoside metabolism" EXACT [GOC:yaf]
is_a: GO:0016116 ! carotenoid metabolic process
is_a: GO:1901804 ! beta-glucoside metabolic process
created_by: yaf
creation_date: 2013-01-22T12:31:56Z

[Term]
id: GO:1901829
name: zeaxanthin bis(beta-D-glucoside) catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of zeaxanthin bis(beta-D-glucoside)." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6288, PMID:20075616, UniPathway:UPA00798]
synonym: "zeaxanthin bis(beta-D-glucoside) breakdown" EXACT [GOC:TermGenie]
synonym: "zeaxanthin bis(beta-D-glucoside) catabolism" EXACT [GOC:TermGenie]
synonym: "zeaxanthin bis(beta-D-glucoside) degradation" EXACT [GOC:TermGenie]
synonym: "zeaxanthin diglucoside breakdown" EXACT [GOC:yaf]
synonym: "zeaxanthin diglucoside catabolism" EXACT [GOC:yaf]
synonym: "zeaxanthin diglucoside degradation" EXACT [GOC:yaf]
is_a: GO:0016118 ! carotenoid catabolic process
is_a: GO:1901805 ! beta-glucoside catabolic process
is_a: GO:1901828 ! zeaxanthin bis(beta-D-glucoside) metabolic process
created_by: yaf
creation_date: 2013-01-22T12:32:06Z

[Term]
id: GO:1901830
name: zeaxanthin bis(beta-D-glucoside) biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of zeaxanthin bis(beta-D-glucoside)." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6288, PMID:20075616, UniPathway:UPA00798]
synonym: "zeaxanthin bis(beta-D-glucoside) anabolism" EXACT [GOC:TermGenie]
synonym: "zeaxanthin bis(beta-D-glucoside) biosynthesis" EXACT [GOC:TermGenie]
synonym: "zeaxanthin bis(beta-D-glucoside) formation" EXACT [GOC:TermGenie]
synonym: "zeaxanthin bis(beta-D-glucoside) synthesis" EXACT [GOC:TermGenie]
synonym: "zeaxanthin diglucoside anabolism" EXACT [GOC:yaf]
synonym: "zeaxanthin diglucoside biosynthesis" EXACT [GOC:yaf]
synonym: "zeaxanthin diglucoside formation" EXACT [GOC:yaf]
synonym: "zeaxanthin diglucoside synthesis" EXACT [GOC:yaf]
is_a: GO:0016117 ! carotenoid biosynthetic process
is_a: GO:1901806 ! beta-glucoside biosynthetic process
is_a: GO:1901828 ! zeaxanthin bis(beta-D-glucoside) metabolic process
created_by: yaf
creation_date: 2013-01-22T12:32:10Z

[Term]
id: GO:1901831
name: all-trans-neoxanthin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving all-trans-neoxanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6809, PMID:11029576, UniPathway:UPA00388]
synonym: "all-trans-neoxanthin metabolism" EXACT [GOC:TermGenie]
synonym: "neoxanthin metabolic process" EXACT [GOC:yaf]
synonym: "neoxanthin metabolism" EXACT [GOC:yaf]
is_a: GO:0016122 ! xanthophyll metabolic process
is_a: GO:0097176 ! epoxide metabolic process
created_by: yaf
creation_date: 2013-01-22T12:43:46Z

[Term]
id: GO:1901832
name: all-trans-neoxanthin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of all-trans-neoxanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6809, PMID:11029576, UniPathway:UPA00388]
synonym: "all-trans-neoxanthin breakdown" EXACT [GOC:TermGenie]
synonym: "all-trans-neoxanthin catabolism" EXACT [GOC:TermGenie]
synonym: "all-trans-neoxanthin degradation" EXACT [GOC:TermGenie]
synonym: "neoxanthin breakdown" EXACT [GOC:yaf]
synonym: "neoxanthin catabolic process" EXACT [GOC:yaf]
synonym: "neoxanthin catabolism" EXACT [GOC:yaf]
synonym: "neoxanthin degradation" EXACT [GOC:yaf]
is_a: GO:0016124 ! xanthophyll catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901502 ! ether catabolic process
is_a: GO:1901831 ! all-trans-neoxanthin metabolic process
created_by: yaf
creation_date: 2013-01-22T12:43:51Z

[Term]
id: GO:1901833
name: all-trans-neoxanthin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of all-trans-neoxanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6809, PMID:11029576, UniPathway:UPA00388]
synonym: "all-trans-neoxanthin anabolism" EXACT [GOC:TermGenie]
synonym: "all-trans-neoxanthin biosynthesis" EXACT [GOC:TermGenie]
synonym: "all-trans-neoxanthin formation" EXACT [GOC:TermGenie]
synonym: "all-trans-neoxanthin synthesis" EXACT [GOC:TermGenie]
synonym: "neoxanthin anabolism" EXACT [GOC:yaf]
synonym: "neoxanthin biosynthesis" EXACT [GOC:yaf]
synonym: "neoxanthin biosynthetic process" EXACT [GOC:yaf]
synonym: "neoxanthin formation" EXACT [GOC:yaf]
synonym: "neoxanthin synthesis" EXACT [GOC:yaf]
is_a: GO:0016123 ! xanthophyll biosynthetic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901503 ! ether biosynthetic process
is_a: GO:1901831 ! all-trans-neoxanthin metabolic process
created_by: yaf
creation_date: 2013-01-22T12:43:56Z

[Term]
id: GO:1901834
name: regulation of deadenylation-independent decapping of nuclear-transcribed mRNA
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of deadenylation-independent decapping of nuclear-transcribed mRNA." [GOC:TermGenie]
synonym: "regulation of deadenylation-independent decapping of nuclear mRNA" RELATED [GOC:TermGenie]
synonym: "regulation of deadenylylation-independent decapping" EXACT [GOC:TermGenie]
is_a: GO:0061013 ! regulation of mRNA catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031087 ! deadenylation-independent decapping of nuclear-transcribed mRNA
relationship: regulates GO:0031087 ! deadenylation-independent decapping of nuclear-transcribed mRNA
created_by: al
creation_date: 2013-01-22T22:42:17Z

[Term]
id: GO:1901835
name: positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of deadenylation-independent decapping of nuclear-transcribed mRNA." [GOC:TermGenie]
synonym: "activation of deadenylation-independent decapping of nuclear mRNA" RELATED [GOC:TermGenie]
synonym: "activation of deadenylation-independent decapping of nuclear-transcribed mRNA" NARROW [GOC:TermGenie]
synonym: "activation of deadenylylation-independent decapping" EXACT [GOC:TermGenie]
synonym: "positive regulation of deadenylation-independent decapping of nuclear mRNA" RELATED [GOC:TermGenie]
synonym: "positive regulation of deadenylylation-independent decapping" EXACT [GOC:TermGenie]
synonym: "up regulation of deadenylation-independent decapping of nuclear mRNA" RELATED [GOC:TermGenie]
synonym: "up regulation of deadenylation-independent decapping of nuclear-transcribed mRNA" EXACT [GOC:TermGenie]
synonym: "up regulation of deadenylylation-independent decapping" EXACT [GOC:TermGenie]
synonym: "up-regulation of deadenylation-independent decapping of nuclear mRNA" RELATED [GOC:TermGenie]
synonym: "up-regulation of deadenylation-independent decapping of nuclear-transcribed mRNA" EXACT [GOC:TermGenie]
synonym: "up-regulation of deadenylylation-independent decapping" EXACT [GOC:TermGenie]
synonym: "upregulation of deadenylation-independent decapping of nuclear mRNA" RELATED [GOC:TermGenie]
synonym: "upregulation of deadenylation-independent decapping of nuclear-transcribed mRNA" EXACT [GOC:TermGenie]
synonym: "upregulation of deadenylylation-independent decapping" EXACT [GOC:TermGenie]
is_a: GO:0061014 ! positive regulation of mRNA catabolic process
is_a: GO:1901834 ! regulation of deadenylation-independent decapping of nuclear-transcribed mRNA
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0031087 ! deadenylation-independent decapping of nuclear-transcribed mRNA
relationship: positively_regulates GO:0031087 ! deadenylation-independent decapping of nuclear-transcribed mRNA
created_by: al
creation_date: 2013-01-22T22:42:22Z

[Term]
id: GO:1901836
name: regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription of nuclear large rRNA transcript from RNA polymerase I promoter." [GOC:sart, GOC:TermGenie]
synonym: "regulation of transcription of nuclear rRNA large Pol I transcript" EXACT [GOC:TermGenie]
is_a: GO:0006356 ! regulation of transcription from RNA polymerase I promoter
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042790 ! transcription of nuclear large rRNA transcript from RNA polymerase I promoter
relationship: regulates GO:0042790 ! transcription of nuclear large rRNA transcript from RNA polymerase I promoter
created_by: sart
creation_date: 2013-01-23T10:16:27Z

[Term]
id: GO:1901837
name: negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription of nuclear large rRNA transcript from RNA polymerase I promoter." [GOC:sart, GOC:TermGenie]
synonym: "down regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter" EXACT [GOC:TermGenie]
synonym: "down regulation of transcription of nuclear rRNA large Pol I transcript" EXACT [GOC:TermGenie]
synonym: "down-regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter" EXACT [GOC:TermGenie]
synonym: "down-regulation of transcription of nuclear rRNA large Pol I transcript" EXACT [GOC:TermGenie]
synonym: "downregulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter" EXACT [GOC:TermGenie]
synonym: "downregulation of transcription of nuclear rRNA large Pol I transcript" EXACT [GOC:TermGenie]
synonym: "inhibition of transcription of nuclear large rRNA transcript from RNA polymerase I promoter" NARROW [GOC:TermGenie]
synonym: "inhibition of transcription of nuclear rRNA large Pol I transcript" EXACT [GOC:TermGenie]
synonym: "negative regulation of transcription of nuclear rRNA large Pol I transcript" EXACT [GOC:TermGenie]
is_a: GO:0016479 ! negative regulation of transcription from RNA polymerase I promoter
is_a: GO:1901836 ! regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042790 ! transcription of nuclear large rRNA transcript from RNA polymerase I promoter
relationship: negatively_regulates GO:0042790 ! transcription of nuclear large rRNA transcript from RNA polymerase I promoter
created_by: sart
creation_date: 2013-01-23T10:16:31Z

[Term]
id: GO:1901838
name: positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transcription of nuclear large rRNA transcript from RNA polymerase I promoter." [GOC:sart, GOC:TermGenie]
synonym: "activation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter" NARROW [GOC:TermGenie]
synonym: "activation of transcription of nuclear rRNA large Pol I transcript" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription of nuclear rRNA large Pol I transcript" EXACT [GOC:TermGenie]
synonym: "up regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of transcription of nuclear rRNA large Pol I transcript" EXACT [GOC:TermGenie]
synonym: "up-regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of transcription of nuclear rRNA large Pol I transcript" EXACT [GOC:TermGenie]
synonym: "upregulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of transcription of nuclear rRNA large Pol I transcript" EXACT [GOC:TermGenie]
is_a: GO:0045943 ! positive regulation of transcription from RNA polymerase I promoter
is_a: GO:1901836 ! regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042790 ! transcription of nuclear large rRNA transcript from RNA polymerase I promoter
relationship: positively_regulates GO:0042790 ! transcription of nuclear large rRNA transcript from RNA polymerase I promoter
created_by: sart
creation_date: 2013-01-23T10:16:36Z

[Term]
id: GO:1901839
name: regulation of RNA polymerase I regulatory region sequence-specific DNA binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of RNA polymerase I regulatory region sequence-specific DNA binding." [GOC:sart, GOC:TermGenie]
is_a: GO:2000677 ! regulation of transcription regulatory region DNA binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001163 ! RNA polymerase I regulatory region sequence-specific DNA binding
relationship: regulates GO:0001163 ! RNA polymerase I regulatory region sequence-specific DNA binding
created_by: sart
creation_date: 2013-01-23T10:24:33Z

[Term]
id: GO:1901840
name: negative regulation of RNA polymerase I regulatory region sequence-specific DNA binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA polymerase I regulatory region sequence-specific DNA binding." [GOC:sart, GOC:TermGenie]
synonym: "down regulation of RNA polymerase I regulatory region sequence-specific DNA binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA polymerase I regulatory region sequence-specific DNA binding" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA polymerase I regulatory region sequence-specific DNA binding" EXACT [GOC:TermGenie]
synonym: "inhibition of RNA polymerase I regulatory region sequence-specific DNA binding" NARROW [GOC:TermGenie]
is_a: GO:1901839 ! regulation of RNA polymerase I regulatory region sequence-specific DNA binding
is_a: GO:2000678 ! negative regulation of transcription regulatory region DNA binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001163 ! RNA polymerase I regulatory region sequence-specific DNA binding
relationship: negatively_regulates GO:0001163 ! RNA polymerase I regulatory region sequence-specific DNA binding
created_by: sart
creation_date: 2013-01-23T10:24:37Z

[Term]
id: GO:1901841
name: regulation of high voltage-gated calcium channel activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of high voltage-gated calcium channel activity." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12754254]
synonym: "regulation of high voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "regulation of high voltage-dependent calcium channel activity" EXACT [GOC:TermGenie]
is_a: GO:1901385 ! regulation of voltage-gated calcium channel activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008331 ! high voltage-gated calcium channel activity
relationship: regulates GO:0008331 ! high voltage-gated calcium channel activity
created_by: rl
creation_date: 2013-01-24T19:02:15Z

[Term]
id: GO:1901842
name: negative regulation of high voltage-gated calcium channel activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of high voltage-gated calcium channel activity." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12754254]
synonym: "down regulation of high voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of high voltage-dependent calcium channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of high voltage-gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of high voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of high voltage-dependent calcium channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of high voltage-gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of high voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of high voltage-dependent calcium channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of high voltage-gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "inhibition of high voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "inhibition of high voltage-dependent calcium channel activity" EXACT [GOC:TermGenie]
synonym: "inhibition of high voltage-gated calcium channel activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of high voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of high voltage-dependent calcium channel activity" EXACT [GOC:TermGenie]
is_a: GO:1901386 ! negative regulation of voltage-gated calcium channel activity
is_a: GO:1901841 ! regulation of high voltage-gated calcium channel activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008331 ! high voltage-gated calcium channel activity
relationship: negatively_regulates GO:0008331 ! high voltage-gated calcium channel activity
created_by: rl
creation_date: 2013-01-24T19:02:20Z

[Term]
id: GO:1901843
name: positive regulation of high voltage-gated calcium channel activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of high voltage-gated calcium channel activity." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12754254]
synonym: "activation of high voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "activation of high voltage-dependent calcium channel activity" EXACT [GOC:TermGenie]
synonym: "activation of high voltage-gated calcium channel activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of high voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of high voltage-dependent calcium channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of high voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of high voltage-dependent calcium channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of high voltage-gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of high voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of high voltage-dependent calcium channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of high voltage-gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of high voltage gated calcium channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of high voltage-dependent calcium channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of high voltage-gated calcium channel activity" EXACT [GOC:TermGenie]
is_a: GO:1901387 ! positive regulation of voltage-gated calcium channel activity
is_a: GO:1901841 ! regulation of high voltage-gated calcium channel activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008331 ! high voltage-gated calcium channel activity
relationship: positively_regulates GO:0008331 ! high voltage-gated calcium channel activity
created_by: rl
creation_date: 2013-01-24T19:02:25Z

[Term]
id: GO:1901844
name: regulation of cell communication by electrical coupling involved in cardiac conduction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell communication by electrical coupling involved in cardiac conduction." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17130302]
is_a: GO:0010649 ! regulation of cell communication by electrical coupling
is_a: GO:1903779 ! regulation of cardiac conduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0086064 ! cell communication by electrical coupling involved in cardiac conduction
relationship: regulates GO:0086064 ! cell communication by electrical coupling involved in cardiac conduction
created_by: rl
creation_date: 2013-01-24T19:15:39Z

[Term]
id: GO:1901845
name: negative regulation of cell communication by electrical coupling involved in cardiac conduction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell communication by electrical coupling involved in cardiac conduction." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17130302]
synonym: "down regulation of cell communication by electrical coupling involved in cardiac conduction" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell communication by electrical coupling involved in cardiac conduction" EXACT [GOC:TermGenie]
synonym: "downregulation of cell communication by electrical coupling involved in cardiac conduction" EXACT [GOC:TermGenie]
synonym: "inhibition of cell communication by electrical coupling involved in cardiac conduction" NARROW [GOC:TermGenie]
is_a: GO:0010651 ! negative regulation of cell communication by electrical coupling
is_a: GO:1901844 ! regulation of cell communication by electrical coupling involved in cardiac conduction
is_a: GO:1903780 ! negative regulation of cardiac conduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0086064 ! cell communication by electrical coupling involved in cardiac conduction
relationship: negatively_regulates GO:0086064 ! cell communication by electrical coupling involved in cardiac conduction
created_by: rl
creation_date: 2013-01-24T19:15:44Z

[Term]
id: GO:1901846
name: positive regulation of cell communication by electrical coupling involved in cardiac conduction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell communication by electrical coupling involved in cardiac conduction." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17130302]
synonym: "activation of cell communication by electrical coupling involved in cardiac conduction" NARROW [GOC:TermGenie]
synonym: "up regulation of cell communication by electrical coupling involved in cardiac conduction" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell communication by electrical coupling involved in cardiac conduction" EXACT [GOC:TermGenie]
synonym: "upregulation of cell communication by electrical coupling involved in cardiac conduction" EXACT [GOC:TermGenie]
is_a: GO:0010650 ! positive regulation of cell communication by electrical coupling
is_a: GO:1901844 ! regulation of cell communication by electrical coupling involved in cardiac conduction
is_a: GO:1903781 ! positive regulation of cardiac conduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0086064 ! cell communication by electrical coupling involved in cardiac conduction
relationship: positively_regulates GO:0086064 ! cell communication by electrical coupling involved in cardiac conduction
created_by: rl
creation_date: 2013-01-24T19:15:49Z

[Term]
id: GO:1901847
name: nicotinate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nicotinate." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00830]
synonym: "nicotinate metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0009820 ! alkaloid metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0072524 ! pyridine-containing compound metabolic process
created_by: yaf
creation_date: 2013-01-28T11:23:48Z

[Term]
id: GO:1901848
name: nicotinate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of nicotinate." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00830]
synonym: "nicotinate breakdown" EXACT [GOC:TermGenie]
synonym: "nicotinate catabolism" EXACT [GOC:TermGenie]
synonym: "nicotinate degradation" EXACT [GOC:TermGenie]
is_a: GO:0009822 ! alkaloid catabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:0072526 ! pyridine-containing compound catabolic process
is_a: GO:1901847 ! nicotinate metabolic process
created_by: yaf
creation_date: 2013-01-28T11:23:52Z

[Term]
id: GO:1901849
name: nicotinate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nicotinate." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00830]
synonym: "nicotinate anabolism" EXACT [GOC:TermGenie]
synonym: "nicotinate biosynthesis" EXACT [GOC:TermGenie]
synonym: "nicotinate formation" EXACT [GOC:TermGenie]
synonym: "nicotinate synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009821 ! alkaloid biosynthetic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:0072525 ! pyridine-containing compound biosynthetic process
is_a: GO:1901847 ! nicotinate metabolic process
created_by: yaf
creation_date: 2013-01-28T11:23:57Z

[Term]
id: GO:1901850
name: 7,8-didemethyl-8-hydroxy-5-deazariboflavin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 7,8-didemethyl-8-hydroxy-5-deazariboflavin." [GOC:TermGenie, GOC:yaf, PMID:14593448, UniPathway:UPA00072]
synonym: "7,8-didemethyl-8-hydroxy-5-deazariboflavin metabolism" EXACT [GOC:TermGenie]
synonym: "coenzyme F0 metabolism" EXACT [GOC:yaf]
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process
created_by: yaf
creation_date: 2013-01-28T11:38:32Z

[Term]
id: GO:1901851
name: 7,8-didemethyl-8-hydroxy-5-deazariboflavin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 7,8-didemethyl-8-hydroxy-5-deazariboflavin." [GOC:TermGenie, GOC:yaf, PMID:14593448, UniPathway:UPA00072]
synonym: "7,8-didemethyl-8-hydroxy-5-deazariboflavin breakdown" EXACT [GOC:TermGenie]
synonym: "7,8-didemethyl-8-hydroxy-5-deazariboflavin catabolism" EXACT [GOC:TermGenie]
synonym: "7,8-didemethyl-8-hydroxy-5-deazariboflavin degradation" EXACT [GOC:TermGenie]
synonym: "coenzyme F0 breakdown" EXACT [GOC:yaf]
synonym: "coenzyme F0 catabolic process" EXACT [GOC:yaf]
synonym: "coenzyme F0 catabolism" EXACT [GOC:yaf]
synonym: "coenzyme F0 degradation" EXACT [GOC:yaf]
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process
is_a: GO:1901850 ! 7,8-didemethyl-8-hydroxy-5-deazariboflavin metabolic process
created_by: yaf
creation_date: 2013-01-28T11:38:36Z

[Term]
id: GO:1901852
name: 7,8-didemethyl-8-hydroxy-5-deazariboflavin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 7,8-didemethyl-8-hydroxy-5-deazariboflavin." [GOC:TermGenie, GOC:yaf, PMID:14593448, UniPathway:UPA00072]
synonym: "7,8-didemethyl-8-hydroxy-5-deazariboflavin anabolism" EXACT [GOC:TermGenie]
synonym: "7,8-didemethyl-8-hydroxy-5-deazariboflavin biosynthesis" EXACT [GOC:TermGenie]
synonym: "7,8-didemethyl-8-hydroxy-5-deazariboflavin formation" EXACT [GOC:TermGenie]
synonym: "7,8-didemethyl-8-hydroxy-5-deazariboflavin synthesis" EXACT [GOC:TermGenie]
synonym: "coenzyme F0 anabolism" EXACT [GOC:yaf]
synonym: "coenzyme F0 biosynthesis" EXACT [GOC:yaf]
synonym: "coenzyme F0 biosynthetic process" EXACT [GOC:yaf]
synonym: "coenzyme F0 formation" EXACT [GOC:yaf]
synonym: "coenzyme F0 synthesis" EXACT [GOC:yaf]
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process
is_a: GO:1901850 ! 7,8-didemethyl-8-hydroxy-5-deazariboflavin metabolic process
created_by: yaf
creation_date: 2013-01-28T11:38:41Z

[Term]
id: GO:1901853
name: 5,6,7,8-tetrahydrosarcinapterin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 5,6,7,8-tetrahydrosarcinapterin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00069]
synonym: "5,6,7,8-tetrahydrosarcinapterin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0072350 ! tricarboxylic acid metabolic process
is_a: GO:2001117 ! tetrahydromethanopterin metabolic process
created_by: yaf
creation_date: 2013-01-28T11:47:52Z

[Term]
id: GO:1901854
name: 5,6,7,8-tetrahydrosarcinapterin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 5,6,7,8-tetrahydrosarcinapterin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00069]
synonym: "5,6,7,8-tetrahydrosarcinapterin breakdown" EXACT [GOC:TermGenie]
synonym: "5,6,7,8-tetrahydrosarcinapterin catabolism" EXACT [GOC:TermGenie]
synonym: "5,6,7,8-tetrahydrosarcinapterin degradation" EXACT [GOC:TermGenie]
is_a: GO:0042560 ! pteridine-containing compound catabolic process
is_a: GO:0046434 ! organophosphate catabolic process
is_a: GO:0072352 ! tricarboxylic acid catabolic process
is_a: GO:1901853 ! 5,6,7,8-tetrahydrosarcinapterin metabolic process
created_by: yaf
creation_date: 2013-01-28T11:48:01Z

[Term]
id: GO:1901855
name: 5,6,7,8-tetrahydrosarcinapterin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 5,6,7,8-tetrahydrosarcinapterin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00069]
synonym: "5,6,7,8-tetrahydrosarcinapterin anabolism" EXACT [GOC:TermGenie]
synonym: "5,6,7,8-tetrahydrosarcinapterin biosynthesis" EXACT [GOC:TermGenie]
synonym: "5,6,7,8-tetrahydrosarcinapterin formation" EXACT [GOC:TermGenie]
synonym: "5,6,7,8-tetrahydrosarcinapterin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0072351 ! tricarboxylic acid biosynthetic process
is_a: GO:1901853 ! 5,6,7,8-tetrahydrosarcinapterin metabolic process
is_a: GO:2001118 ! tetrahydromethanopterin biosynthetic process
created_by: yaf
creation_date: 2013-01-28T11:48:05Z

[Term]
id: GO:1901856
name: negative regulation of cellular respiration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular respiration." [GOC:TermGenie, GOC:yaf, PMID:23150719]
synonym: "down regulation of cellular respiration" EXACT [GOC:TermGenie]
synonym: "down regulation of oxidative metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of oxidative metabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of respiration" BROAD [GOC:TermGenie]
synonym: "down-regulation of cellular respiration" EXACT [GOC:TermGenie]
synonym: "down-regulation of oxidative metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of oxidative metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of respiration" BROAD [GOC:TermGenie]
synonym: "downregulation of cellular respiration" EXACT [GOC:TermGenie]
synonym: "downregulation of oxidative metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of oxidative metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of respiration" BROAD [GOC:TermGenie]
synonym: "inhibition of cellular respiration" NARROW [GOC:TermGenie]
synonym: "inhibition of oxidative metabolic process" EXACT [GOC:TermGenie]
synonym: "inhibition of oxidative metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of respiration" BROAD [GOC:TermGenie]
synonym: "negative regulation of oxidative metabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of oxidative metabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of respiration" BROAD [GOC:TermGenie]
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0043457 ! regulation of cellular respiration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045333 ! cellular respiration
relationship: negatively_regulates GO:0045333 ! cellular respiration
created_by: yaf
creation_date: 2013-02-01T09:56:23Z

[Term]
id: GO:1901857
name: positive regulation of cellular respiration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellular respiration." [GOC:TermGenie, GOC:yaf, PMID:23150719]
synonym: "activation of cellular respiration" NARROW [GOC:TermGenie]
synonym: "activation of oxidative metabolic process" EXACT [GOC:TermGenie]
synonym: "activation of oxidative metabolism" EXACT [GOC:TermGenie]
synonym: "activation of respiration" BROAD [GOC:TermGenie]
synonym: "positive regulation of oxidative metabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of oxidative metabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of respiration" BROAD [GOC:TermGenie]
synonym: "up regulation of cellular respiration" EXACT [GOC:TermGenie]
synonym: "up regulation of oxidative metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of oxidative metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of respiration" BROAD [GOC:TermGenie]
synonym: "up-regulation of cellular respiration" EXACT [GOC:TermGenie]
synonym: "up-regulation of oxidative metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of oxidative metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of respiration" BROAD [GOC:TermGenie]
synonym: "upregulation of cellular respiration" EXACT [GOC:TermGenie]
synonym: "upregulation of oxidative metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of oxidative metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of respiration" BROAD [GOC:TermGenie]
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0043457 ! regulation of cellular respiration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045333 ! cellular respiration
relationship: positively_regulates GO:0045333 ! cellular respiration
created_by: yaf
creation_date: 2013-02-01T09:56:28Z

[Term]
id: GO:1901858
name: regulation of mitochondrial DNA metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitochondrial DNA metabolic process." [GOC:TermGenie, GOC:yaf, PMID:23150719]
synonym: "regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie]
synonym: "regulation of mtDNA metabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of mtDNA metabolism" EXACT [GOC:TermGenie]
is_a: GO:0010821 ! regulation of mitochondrion organization
is_a: GO:0051052 ! regulation of DNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032042 ! mitochondrial DNA metabolic process
relationship: regulates GO:0032042 ! mitochondrial DNA metabolic process
created_by: yaf
creation_date: 2013-02-01T10:05:04Z

[Term]
id: GO:1901859
name: negative regulation of mitochondrial DNA metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial DNA metabolic process." [GOC:TermGenie, GOC:yaf, PMID:23150719]
synonym: "down regulation of mitochondrial DNA metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of mtDNA metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of mtDNA metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitochondrial DNA metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of mtDNA metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of mtDNA metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of mitochondrial DNA metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of mtDNA metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of mtDNA metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of mitochondrial DNA metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of mitochondrial DNA metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of mtDNA metabolic process" EXACT [GOC:TermGenie]
synonym: "inhibition of mtDNA metabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of mtDNA metabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of mtDNA metabolism" EXACT [GOC:TermGenie]
is_a: GO:0010823 ! negative regulation of mitochondrion organization
is_a: GO:0051053 ! negative regulation of DNA metabolic process
is_a: GO:1901858 ! regulation of mitochondrial DNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032042 ! mitochondrial DNA metabolic process
relationship: negatively_regulates GO:0032042 ! mitochondrial DNA metabolic process
created_by: yaf
creation_date: 2013-02-01T10:05:09Z

[Term]
id: GO:1901860
name: positive regulation of mitochondrial DNA metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitochondrial DNA metabolic process." [GOC:TermGenie, GOC:yaf, PMID:23150719]
synonym: "activation of mitochondrial DNA metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie]
synonym: "activation of mtDNA metabolic process" EXACT [GOC:TermGenie]
synonym: "activation of mtDNA metabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of mtDNA metabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of mtDNA metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of mitochondrial DNA metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of mtDNA metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of mtDNA metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitochondrial DNA metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of mtDNA metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of mtDNA metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of mitochondrial DNA metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of mtDNA metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of mtDNA metabolism" EXACT [GOC:TermGenie]
is_a: GO:0010822 ! positive regulation of mitochondrion organization
is_a: GO:0051054 ! positive regulation of DNA metabolic process
is_a: GO:1901858 ! regulation of mitochondrial DNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032042 ! mitochondrial DNA metabolic process
relationship: positively_regulates GO:0032042 ! mitochondrial DNA metabolic process
created_by: yaf
creation_date: 2013-02-01T10:05:14Z

[Term]
id: GO:1901861
name: regulation of muscle tissue development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of muscle tissue development." [GOC:TermGenie, GOC:yaf, PMID:23150719]
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060537 ! muscle tissue development
relationship: regulates GO:0060537 ! muscle tissue development
created_by: yaf
creation_date: 2013-02-01T10:30:47Z

[Term]
id: GO:1901862
name: negative regulation of muscle tissue development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of muscle tissue development." [GOC:TermGenie, GOC:yaf, PMID:23150719]
synonym: "down regulation of muscle tissue development" EXACT [GOC:TermGenie]
synonym: "down-regulation of muscle tissue development" EXACT [GOC:TermGenie]
synonym: "downregulation of muscle tissue development" EXACT [GOC:TermGenie]
synonym: "inhibition of muscle tissue development" NARROW [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:1901861 ! regulation of muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060537 ! muscle tissue development
relationship: negatively_regulates GO:0060537 ! muscle tissue development
created_by: yaf
creation_date: 2013-02-01T10:30:52Z

[Term]
id: GO:1901863
name: positive regulation of muscle tissue development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of muscle tissue development." [GOC:TermGenie, GOC:yaf, PMID:23150719]
synonym: "activation of muscle tissue development" NARROW [GOC:TermGenie]
synonym: "up regulation of muscle tissue development" EXACT [GOC:TermGenie]
synonym: "up-regulation of muscle tissue development" EXACT [GOC:TermGenie]
synonym: "upregulation of muscle tissue development" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:1901861 ! regulation of muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060537 ! muscle tissue development
relationship: positively_regulates GO:0060537 ! muscle tissue development
created_by: yaf
creation_date: 2013-02-01T10:30:57Z

[Term]
id: GO:1901864
name: capsorubin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving capsorubin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5174, UniPathway:UPA00807]
synonym: "capsorubin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0016122 ! xanthophyll metabolic process
created_by: yaf
creation_date: 2013-02-04T10:50:13Z

[Term]
id: GO:1901865
name: capsorubin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of capsorubin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5174, UniPathway:UPA00807]
synonym: "capsorubin breakdown" EXACT [GOC:TermGenie]
synonym: "capsorubin catabolism" EXACT [GOC:TermGenie]
synonym: "capsorubin degradation" EXACT [GOC:TermGenie]
is_a: GO:0016124 ! xanthophyll catabolic process
is_a: GO:1901864 ! capsorubin metabolic process
created_by: yaf
creation_date: 2013-02-04T10:50:17Z

[Term]
id: GO:1901866
name: capsorubin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of capsorubin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5174, UniPathway:UPA00807]
synonym: "capsorubin anabolism" EXACT [GOC:TermGenie]
synonym: "capsorubin biosynthesis" EXACT [GOC:TermGenie]
synonym: "capsorubin formation" EXACT [GOC:TermGenie]
synonym: "capsorubin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0016123 ! xanthophyll biosynthetic process
is_a: GO:1901864 ! capsorubin metabolic process
created_by: yaf
creation_date: 2013-02-04T10:50:26Z

[Term]
id: GO:1901867
name: ecgonine methyl ester metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ecgonine methyl ester." [GOC:TermGenie, PMID:22665766]
synonym: "ecgonine methyl ester metabolism" EXACT [GOC:TermGenie]
is_a: GO:0046448 ! tropane alkaloid metabolic process
is_a: GO:0097164 ! ammonium ion metabolic process
created_by: michel.schneider
creation_date: 2013-02-04T11:58:14Z

[Term]
id: GO:1901868
name: ecgonine methyl ester catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ecgonine methyl ester." [GOC:TermGenie, PMID:22665766]
synonym: "ecgonine methyl ester breakdown" EXACT [GOC:TermGenie]
synonym: "ecgonine methyl ester catabolism" EXACT [GOC:TermGenie]
synonym: "ecgonine methyl ester degradation" EXACT [GOC:TermGenie]
is_a: GO:0009822 ! alkaloid catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901867 ! ecgonine methyl ester metabolic process
created_by: michel.schneider
creation_date: 2013-02-04T11:58:18Z

[Term]
id: GO:1901869
name: ecgonine methyl ester biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ecgonine methyl ester." [GOC:TermGenie, PMID:22665766]
synonym: "ecgonine methyl ester anabolism" EXACT [GOC:TermGenie]
synonym: "ecgonine methyl ester biosynthesis" EXACT [GOC:TermGenie]
synonym: "ecgonine methyl ester formation" EXACT [GOC:TermGenie]
synonym: "ecgonine methyl ester synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009710 ! tropane alkaloid biosynthetic process
is_a: GO:1901867 ! ecgonine methyl ester metabolic process
created_by: michel.schneider
creation_date: 2013-02-04T11:58:25Z

[Term]
id: GO:1901870
name: ecgonone methyl ester metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ecgonone methyl ester." [GOC:TermGenie, PMID:22665766]
synonym: "ecgonone methyl ester metabolism" EXACT [GOC:TermGenie]
is_a: GO:0042180 ! cellular ketone metabolic process
is_a: GO:0046448 ! tropane alkaloid metabolic process
is_a: GO:0097164 ! ammonium ion metabolic process
created_by: michel.schneider
creation_date: 2013-02-04T11:58:30Z

[Term]
id: GO:1901871
name: ecgonone methyl ester catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ecgonone methyl ester." [GOC:TermGenie, PMID:22665766]
synonym: "ecgonone methyl ester breakdown" EXACT [GOC:TermGenie]
synonym: "ecgonone methyl ester catabolism" EXACT [GOC:TermGenie]
synonym: "ecgonone methyl ester degradation" EXACT [GOC:TermGenie]
is_a: GO:0009822 ! alkaloid catabolic process
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901870 ! ecgonone methyl ester metabolic process
created_by: michel.schneider
creation_date: 2013-02-04T11:58:34Z

[Term]
id: GO:1901872
name: ecgonone methyl ester biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ecgonone methyl ester." [GOC:TermGenie, PMID:22665766]
synonym: "ecgonone methyl ester anabolism" EXACT [GOC:TermGenie]
synonym: "ecgonone methyl ester biosynthesis" EXACT [GOC:TermGenie]
synonym: "ecgonone methyl ester formation" EXACT [GOC:TermGenie]
synonym: "ecgonone methyl ester synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009710 ! tropane alkaloid biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:1901870 ! ecgonone methyl ester metabolic process
created_by: michel.schneider
creation_date: 2013-02-04T11:58:39Z

[Term]
id: GO:1901873
name: regulation of post-translational protein modification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of post-translational protein modification." [GOC:TermGenie, GOC:yaf, PMID:21209915]
synonym: "regulation of post-translational amino acid modification" EXACT [GOC:TermGenie]
synonym: "regulation of post-translational modification" EXACT [GOC:TermGenie]
synonym: "regulation of posttranslational amino acid modification" EXACT [GOC:TermGenie]
synonym: "regulation of posttranslational modification" EXACT [GOC:TermGenie]
synonym: "regulation of posttranslational protein modification" EXACT [GOC:TermGenie]
synonym: "regulation of PTM" EXACT [GOC:TermGenie]
is_a: GO:0031399 ! regulation of protein modification process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043687 ! post-translational protein modification
relationship: regulates GO:0043687 ! post-translational protein modification
created_by: yaf
creation_date: 2013-02-05T10:02:52Z

[Term]
id: GO:1901874
name: negative regulation of post-translational protein modification
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of post-translational protein modification." [GOC:TermGenie, GOC:yaf, PMID:21209915]
synonym: "down regulation of post-translational amino acid modification" EXACT [GOC:TermGenie]
synonym: "down regulation of post-translational modification" EXACT [GOC:TermGenie]
synonym: "down regulation of post-translational protein modification" EXACT [GOC:TermGenie]
synonym: "down regulation of posttranslational amino acid modification" EXACT [GOC:TermGenie]
synonym: "down regulation of posttranslational modification" EXACT [GOC:TermGenie]
synonym: "down regulation of posttranslational protein modification" EXACT [GOC:TermGenie]
synonym: "down regulation of PTM" EXACT [GOC:TermGenie]
synonym: "down-regulation of post-translational amino acid modification" EXACT [GOC:TermGenie]
synonym: "down-regulation of post-translational modification" EXACT [GOC:TermGenie]
synonym: "down-regulation of post-translational protein modification" EXACT [GOC:TermGenie]
synonym: "down-regulation of posttranslational amino acid modification" EXACT [GOC:TermGenie]
synonym: "down-regulation of posttranslational modification" EXACT [GOC:TermGenie]
synonym: "down-regulation of posttranslational protein modification" EXACT [GOC:TermGenie]
synonym: "down-regulation of PTM" EXACT [GOC:TermGenie]
synonym: "downregulation of post-translational amino acid modification" EXACT [GOC:TermGenie]
synonym: "downregulation of post-translational modification" EXACT [GOC:TermGenie]
synonym: "downregulation of post-translational protein modification" EXACT [GOC:TermGenie]
synonym: "downregulation of posttranslational amino acid modification" EXACT [GOC:TermGenie]
synonym: "downregulation of posttranslational modification" EXACT [GOC:TermGenie]
synonym: "downregulation of posttranslational protein modification" EXACT [GOC:TermGenie]
synonym: "downregulation of PTM" EXACT [GOC:TermGenie]
synonym: "inhibition of post-translational amino acid modification" EXACT [GOC:TermGenie]
synonym: "inhibition of post-translational modification" EXACT [GOC:TermGenie]
synonym: "inhibition of post-translational protein modification" NARROW [GOC:TermGenie]
synonym: "inhibition of posttranslational amino acid modification" EXACT [GOC:TermGenie]
synonym: "inhibition of posttranslational modification" EXACT [GOC:TermGenie]
synonym: "inhibition of posttranslational protein modification" EXACT [GOC:TermGenie]
synonym: "inhibition of PTM" EXACT [GOC:TermGenie]
synonym: "negative regulation of post-translational amino acid modification" EXACT [GOC:TermGenie]
synonym: "negative regulation of post-translational modification" EXACT [GOC:TermGenie]
synonym: "negative regulation of posttranslational amino acid modification" EXACT [GOC:TermGenie]
synonym: "negative regulation of posttranslational modification" EXACT [GOC:TermGenie]
synonym: "negative regulation of posttranslational protein modification" EXACT [GOC:TermGenie]
synonym: "negative regulation of PTM" EXACT [GOC:TermGenie]
is_a: GO:0031400 ! negative regulation of protein modification process
is_a: GO:1901873 ! regulation of post-translational protein modification
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043687 ! post-translational protein modification
relationship: negatively_regulates GO:0043687 ! post-translational protein modification
created_by: yaf
creation_date: 2013-02-05T10:02:57Z

[Term]
id: GO:1901875
name: positive regulation of post-translational protein modification
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of post-translational protein modification." [GOC:TermGenie, GOC:yaf, PMID:21209915]
synonym: "activation of post-translational amino acid modification" EXACT [GOC:TermGenie]
synonym: "activation of post-translational modification" EXACT [GOC:TermGenie]
synonym: "activation of post-translational protein modification" NARROW [GOC:TermGenie]
synonym: "activation of posttranslational amino acid modification" EXACT [GOC:TermGenie]
synonym: "activation of posttranslational modification" EXACT [GOC:TermGenie]
synonym: "activation of posttranslational protein modification" EXACT [GOC:TermGenie]
synonym: "activation of PTM" EXACT [GOC:TermGenie]
synonym: "positive regulation of post-translational amino acid modification" EXACT [GOC:TermGenie]
synonym: "positive regulation of post-translational modification" EXACT [GOC:TermGenie]
synonym: "positive regulation of posttranslational amino acid modification" EXACT [GOC:TermGenie]
synonym: "positive regulation of posttranslational modification" EXACT [GOC:TermGenie]
synonym: "positive regulation of posttranslational protein modification" EXACT [GOC:TermGenie]
synonym: "positive regulation of PTM" EXACT [GOC:TermGenie]
synonym: "up regulation of post-translational amino acid modification" EXACT [GOC:TermGenie]
synonym: "up regulation of post-translational modification" EXACT [GOC:TermGenie]
synonym: "up regulation of post-translational protein modification" EXACT [GOC:TermGenie]
synonym: "up regulation of posttranslational amino acid modification" EXACT [GOC:TermGenie]
synonym: "up regulation of posttranslational modification" EXACT [GOC:TermGenie]
synonym: "up regulation of posttranslational protein modification" EXACT [GOC:TermGenie]
synonym: "up regulation of PTM" EXACT [GOC:TermGenie]
synonym: "up-regulation of post-translational amino acid modification" EXACT [GOC:TermGenie]
synonym: "up-regulation of post-translational modification" EXACT [GOC:TermGenie]
synonym: "up-regulation of post-translational protein modification" EXACT [GOC:TermGenie]
synonym: "up-regulation of posttranslational amino acid modification" EXACT [GOC:TermGenie]
synonym: "up-regulation of posttranslational modification" EXACT [GOC:TermGenie]
synonym: "up-regulation of posttranslational protein modification" EXACT [GOC:TermGenie]
synonym: "up-regulation of PTM" EXACT [GOC:TermGenie]
synonym: "upregulation of post-translational amino acid modification" EXACT [GOC:TermGenie]
synonym: "upregulation of post-translational modification" EXACT [GOC:TermGenie]
synonym: "upregulation of post-translational protein modification" EXACT [GOC:TermGenie]
synonym: "upregulation of posttranslational amino acid modification" EXACT [GOC:TermGenie]
synonym: "upregulation of posttranslational modification" EXACT [GOC:TermGenie]
synonym: "upregulation of posttranslational protein modification" EXACT [GOC:TermGenie]
synonym: "upregulation of PTM" EXACT [GOC:TermGenie]
is_a: GO:0031401 ! positive regulation of protein modification process
is_a: GO:1901873 ! regulation of post-translational protein modification
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043687 ! post-translational protein modification
relationship: positively_regulates GO:0043687 ! post-translational protein modification
created_by: yaf
creation_date: 2013-02-05T10:03:02Z

[Term]
id: GO:1901876
name: regulation of calcium ion binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of calcium ion binding." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16432188]
synonym: "regulation of calcium ion storage activity" RELATED [GOC:TermGenie]
is_a: GO:0051098 ! regulation of binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0005509 ! calcium ion binding
relationship: regulates GO:0005509 ! calcium ion binding
created_by: rl
creation_date: 2013-02-06T12:38:12Z

[Term]
id: GO:1901877
name: negative regulation of calcium ion binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion binding." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16432188]
synonym: "down regulation of calcium ion binding" EXACT [GOC:TermGenie]
synonym: "down regulation of calcium ion storage activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of calcium ion binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of calcium ion storage activity" RELATED [GOC:TermGenie]
synonym: "downregulation of calcium ion binding" EXACT [GOC:TermGenie]
synonym: "downregulation of calcium ion storage activity" RELATED [GOC:TermGenie]
synonym: "inhibition of calcium ion binding" NARROW [GOC:TermGenie]
synonym: "inhibition of calcium ion storage activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of calcium ion storage activity" RELATED [GOC:TermGenie]
is_a: GO:0051100 ! negative regulation of binding
is_a: GO:1901876 ! regulation of calcium ion binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0005509 ! calcium ion binding
relationship: negatively_regulates GO:0005509 ! calcium ion binding
created_by: rl
creation_date: 2013-02-06T12:38:22Z

[Term]
id: GO:1901878
name: positive regulation of calcium ion binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of calcium ion binding." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16432188]
synonym: "activation of calcium ion binding" NARROW [GOC:TermGenie]
synonym: "activation of calcium ion storage activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of calcium ion storage activity" RELATED [GOC:TermGenie]
synonym: "up regulation of calcium ion binding" EXACT [GOC:TermGenie]
synonym: "up regulation of calcium ion storage activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of calcium ion binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of calcium ion storage activity" RELATED [GOC:TermGenie]
synonym: "upregulation of calcium ion binding" EXACT [GOC:TermGenie]
synonym: "upregulation of calcium ion storage activity" RELATED [GOC:TermGenie]
is_a: GO:0051099 ! positive regulation of binding
is_a: GO:1901876 ! regulation of calcium ion binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0005509 ! calcium ion binding
relationship: positively_regulates GO:0005509 ! calcium ion binding
created_by: rl
creation_date: 2013-02-06T12:38:26Z

[Term]
id: GO:1901879
name: regulation of protein depolymerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein depolymerization." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12032137]
synonym: "regulation of protein polymer breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of protein polymer catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of protein polymer catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of protein polymer degradation" EXACT [GOC:TermGenie]
is_a: GO:0043244 ! regulation of protein complex disassembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051261 ! protein depolymerization
relationship: regulates GO:0051261 ! protein depolymerization
created_by: rl
creation_date: 2013-02-06T13:57:23Z

[Term]
id: GO:1901880
name: negative regulation of protein depolymerization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein depolymerization." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12032137]
synonym: "down regulation of protein depolymerization" EXACT [GOC:TermGenie]
synonym: "down regulation of protein polymer breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of protein polymer catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of protein polymer catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of protein polymer degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein depolymerization" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein polymer breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein polymer catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein polymer catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein polymer degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of protein depolymerization" EXACT [GOC:TermGenie]
synonym: "downregulation of protein polymer breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of protein polymer catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of protein polymer catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of protein polymer degradation" EXACT [GOC:TermGenie]
synonym: "inhibition of protein depolymerization" NARROW [GOC:TermGenie]
synonym: "inhibition of protein polymer breakdown" EXACT [GOC:TermGenie]
synonym: "inhibition of protein polymer catabolic process" EXACT [GOC:TermGenie]
synonym: "inhibition of protein polymer catabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of protein polymer degradation" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein polymer breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein polymer catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein polymer catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein polymer degradation" EXACT [GOC:TermGenie]
is_a: GO:0043242 ! negative regulation of protein complex disassembly
is_a: GO:1901879 ! regulation of protein depolymerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051261 ! protein depolymerization
relationship: negatively_regulates GO:0051261 ! protein depolymerization
created_by: rl
creation_date: 2013-02-06T13:57:28Z

[Term]
id: GO:1901881
name: positive regulation of protein depolymerization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein depolymerization." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12032137]
synonym: "activation of protein depolymerization" NARROW [GOC:TermGenie]
synonym: "activation of protein polymer breakdown" EXACT [GOC:TermGenie]
synonym: "activation of protein polymer catabolic process" EXACT [GOC:TermGenie]
synonym: "activation of protein polymer catabolism" EXACT [GOC:TermGenie]
synonym: "activation of protein polymer degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein polymer breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein polymer catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein polymer catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein polymer degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of protein depolymerization" EXACT [GOC:TermGenie]
synonym: "up regulation of protein polymer breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of protein polymer catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of protein polymer catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of protein polymer degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein depolymerization" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein polymer breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein polymer catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein polymer catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein polymer degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of protein depolymerization" EXACT [GOC:TermGenie]
synonym: "upregulation of protein polymer breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of protein polymer catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of protein polymer catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of protein polymer degradation" EXACT [GOC:TermGenie]
is_a: GO:0043243 ! positive regulation of protein complex disassembly
is_a: GO:1901879 ! regulation of protein depolymerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051261 ! protein depolymerization
relationship: positively_regulates GO:0051261 ! protein depolymerization
created_by: rl
creation_date: 2013-02-06T13:57:32Z

[Term]
id: GO:1901882
name: 4-hydroxycoumarin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 4-hydroxycoumarin." [GOC:TermGenie, pmid:19757094]
synonym: "4-hydroxycoumarin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009804 ! coumarin metabolic process
created_by: michel.schneider
creation_date: 2013-02-06T14:05:50Z

[Term]
id: GO:1901883
name: 4-hydroxycoumarin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 4-hydroxycoumarin." [GOC:TermGenie, pmid:19757094]
synonym: "4-hydroxycoumarin breakdown" EXACT [GOC:TermGenie]
synonym: "4-hydroxycoumarin catabolism" EXACT [GOC:TermGenie]
synonym: "4-hydroxycoumarin degradation" EXACT [GOC:TermGenie]
is_a: GO:0046226 ! coumarin catabolic process
is_a: GO:1901882 ! 4-hydroxycoumarin metabolic process
created_by: michel.schneider
creation_date: 2013-02-06T14:05:54Z

[Term]
id: GO:1901884
name: 4-hydroxycoumarin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 4-hydroxycoumarin." [GOC:TermGenie, pmid:19757094]
synonym: "4-hydroxycoumarin anabolism" EXACT [GOC:TermGenie]
synonym: "4-hydroxycoumarin biosynthesis" EXACT [GOC:TermGenie]
synonym: "4-hydroxycoumarin formation" EXACT [GOC:TermGenie]
synonym: "4-hydroxycoumarin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009805 ! coumarin biosynthetic process
is_a: GO:1901882 ! 4-hydroxycoumarin metabolic process
created_by: michel.schneider
creation_date: 2013-02-06T14:05:59Z

[Term]
id: GO:1901885
name: 2-hydroxybenzoyl-CoA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 2-hydroxybenzoyl-CoA." [GOC:TermGenie, pmid:19757094]
synonym: "2-hydroxybenzoyl-CoA metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006637 ! acyl-CoA metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
created_by: michel.schneider
creation_date: 2013-02-06T14:06:03Z

[Term]
id: GO:1901886
name: 2-hydroxybenzoyl-CoA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 2-hydroxybenzoyl-CoA." [GOC:TermGenie, pmid:19757094]
synonym: "2-hydroxybenzoyl-CoA breakdown" EXACT [GOC:TermGenie]
synonym: "2-hydroxybenzoyl-CoA catabolism" EXACT [GOC:TermGenie]
synonym: "2-hydroxybenzoyl-CoA degradation" EXACT [GOC:TermGenie]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:1901885 ! 2-hydroxybenzoyl-CoA metabolic process
created_by: michel.schneider
creation_date: 2013-02-06T14:06:08Z

[Term]
id: GO:1901887
name: 2-hydroxybenzoyl-CoA biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 2-hydroxybenzoyl-CoA." [GOC:TermGenie, pmid:19757094]
synonym: "2-hydroxybenzoyl-CoA anabolism" EXACT [GOC:TermGenie]
synonym: "2-hydroxybenzoyl-CoA biosynthesis" EXACT [GOC:TermGenie]
synonym: "2-hydroxybenzoyl-CoA formation" EXACT [GOC:TermGenie]
synonym: "2-hydroxybenzoyl-CoA synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:0071616 ! acyl-CoA biosynthetic process
is_a: GO:1901885 ! 2-hydroxybenzoyl-CoA metabolic process
created_by: michel.schneider
creation_date: 2013-02-06T14:06:12Z

[Term]
id: GO:1901888
name: regulation of cell junction assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell junction assembly." [GOC:TermGenie]
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034329 ! cell junction assembly
relationship: regulates GO:0034329 ! cell junction assembly
created_by: tb
creation_date: 2013-02-06T19:40:32Z

[Term]
id: GO:1901889
name: negative regulation of cell junction assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell junction assembly." [GOC:TermGenie]
synonym: "down regulation of cell junction assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell junction assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of cell junction assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of cell junction assembly" NARROW [GOC:TermGenie]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1901888 ! regulation of cell junction assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034329 ! cell junction assembly
relationship: negatively_regulates GO:0034329 ! cell junction assembly
created_by: tb
creation_date: 2013-02-06T19:40:41Z

[Term]
id: GO:1901890
name: positive regulation of cell junction assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell junction assembly." [GOC:TermGenie]
synonym: "activation of cell junction assembly" NARROW [GOC:TermGenie]
synonym: "up regulation of cell junction assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell junction assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of cell junction assembly" EXACT [GOC:TermGenie]
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1901888 ! regulation of cell junction assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034329 ! cell junction assembly
relationship: positively_regulates GO:0034329 ! cell junction assembly
created_by: tb
creation_date: 2013-02-06T19:40:46Z

[Term]
id: GO:1901891
name: regulation of cell septum assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell septum assembly." [GOC:TermGenie]
is_a: GO:0032954 ! regulation of cytokinetic process
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0090529 ! cell septum assembly
relationship: regulates GO:0090529 ! cell septum assembly
created_by: tb
creation_date: 2013-02-06T20:14:40Z

[Term]
id: GO:1901892
name: negative regulation of cell septum assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell septum assembly." [GOC:TermGenie]
synonym: "down regulation of cell septum assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell septum assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of cell septum assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of cell septum assembly" NARROW [GOC:TermGenie]
is_a: GO:0032466 ! negative regulation of cytokinesis
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1901891 ! regulation of cell septum assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0090529 ! cell septum assembly
relationship: negatively_regulates GO:0090529 ! cell septum assembly
created_by: tb
creation_date: 2013-02-06T20:14:45Z

[Term]
id: GO:1901893
name: positive regulation of cell septum assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell septum assembly." [GOC:TermGenie]
synonym: "activation of cell septum assembly" NARROW [GOC:TermGenie]
synonym: "up regulation of cell septum assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell septum assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of cell septum assembly" EXACT [GOC:TermGenie]
is_a: GO:0032467 ! positive regulation of cytokinesis
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1901891 ! regulation of cell septum assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0090529 ! cell septum assembly
relationship: positively_regulates GO:0090529 ! cell septum assembly
created_by: tb
creation_date: 2013-02-06T20:14:50Z

[Term]
id: GO:1901894
name: regulation of calcium-transporting ATPase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of calcium-transporting ATPase activity." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19708671]
synonym: "regulation of ATP phosphohydrolase (Ca2+-transporting)" EXACT [GOC:TermGenie]
synonym: "regulation of Ca(2+)-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "regulation of Ca2+-pumping ATPase activity" EXACT [GOC:TermGenie]
synonym: "regulation of Ca2+-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "regulation of calcium ABC transporter" NARROW [GOC:TermGenie]
synonym: "regulation of calcium efflux ATPase" NARROW [GOC:TermGenie]
synonym: "regulation of calcium pump" BROAD [GOC:TermGenie]
synonym: "regulation of calcium transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "regulation of calcium-translocating P-type ATPase activity" NARROW [GOC:TermGenie]
synonym: "regulation of plasma membrane Ca-ATPase" NARROW [GOC:TermGenie]
synonym: "regulation of sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW [GOC:TermGenie]
synonym: "regulation of sarcoplasmic reticulum ATPase" NARROW [GOC:TermGenie]
is_a: GO:0043462 ! regulation of ATPase activity
is_a: GO:1901019 ! regulation of calcium ion transmembrane transporter activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0005388 ! calcium-transporting ATPase activity
relationship: regulates GO:0005388 ! calcium-transporting ATPase activity
created_by: rl
creation_date: 2013-02-06T21:18:16Z

[Term]
id: GO:1901895
name: negative regulation of calcium-transporting ATPase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium-transporting ATPase activity." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19708671]
synonym: "down regulation of ATP phosphohydrolase (Ca2+-transporting)" EXACT [GOC:TermGenie]
synonym: "down regulation of Ca(2+)-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of Ca2+-pumping ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of Ca2+-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of calcium ABC transporter" NARROW [GOC:TermGenie]
synonym: "down regulation of calcium efflux ATPase" NARROW [GOC:TermGenie]
synonym: "down regulation of calcium pump" BROAD [GOC:TermGenie]
synonym: "down regulation of calcium transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of calcium-translocating P-type ATPase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of calcium-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of plasma membrane Ca-ATPase" NARROW [GOC:TermGenie]
synonym: "down regulation of sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW [GOC:TermGenie]
synonym: "down regulation of sarcoplasmic reticulum ATPase" NARROW [GOC:TermGenie]
synonym: "down-regulation of ATP phosphohydrolase (Ca2+-transporting)" EXACT [GOC:TermGenie]
synonym: "down-regulation of Ca(2+)-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of Ca2+-pumping ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of Ca2+-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of calcium ABC transporter" NARROW [GOC:TermGenie]
synonym: "down-regulation of calcium efflux ATPase" NARROW [GOC:TermGenie]
synonym: "down-regulation of calcium pump" BROAD [GOC:TermGenie]
synonym: "down-regulation of calcium transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of calcium-translocating P-type ATPase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of calcium-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of plasma membrane Ca-ATPase" NARROW [GOC:TermGenie]
synonym: "down-regulation of sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW [GOC:TermGenie]
synonym: "down-regulation of sarcoplasmic reticulum ATPase" NARROW [GOC:TermGenie]
synonym: "downregulation of ATP phosphohydrolase (Ca2+-transporting)" EXACT [GOC:TermGenie]
synonym: "downregulation of Ca(2+)-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of Ca2+-pumping ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of Ca2+-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of calcium ABC transporter" NARROW [GOC:TermGenie]
synonym: "downregulation of calcium efflux ATPase" NARROW [GOC:TermGenie]
synonym: "downregulation of calcium pump" BROAD [GOC:TermGenie]
synonym: "downregulation of calcium transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of calcium-translocating P-type ATPase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of calcium-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of plasma membrane Ca-ATPase" NARROW [GOC:TermGenie]
synonym: "downregulation of sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW [GOC:TermGenie]
synonym: "downregulation of sarcoplasmic reticulum ATPase" NARROW [GOC:TermGenie]
synonym: "inhibition of ATP phosphohydrolase (Ca2+-transporting)" EXACT [GOC:TermGenie]
synonym: "inhibition of Ca(2+)-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of Ca2+-pumping ATPase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of Ca2+-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of calcium ABC transporter" NARROW [GOC:TermGenie]
synonym: "inhibition of calcium efflux ATPase" NARROW [GOC:TermGenie]
synonym: "inhibition of calcium pump" BROAD [GOC:TermGenie]
synonym: "inhibition of calcium transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of calcium-translocating P-type ATPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of calcium-transporting ATPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of plasma membrane Ca-ATPase" NARROW [GOC:TermGenie]
synonym: "inhibition of sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW [GOC:TermGenie]
synonym: "inhibition of sarcoplasmic reticulum ATPase" NARROW [GOC:TermGenie]
synonym: "negative regulation of ATP phosphohydrolase (Ca2+-transporting)" EXACT [GOC:TermGenie]
synonym: "negative regulation of Ca(2+)-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of Ca2+-pumping ATPase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of Ca2+-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of calcium ABC transporter" NARROW [GOC:TermGenie]
synonym: "negative regulation of calcium efflux ATPase" NARROW [GOC:TermGenie]
synonym: "negative regulation of calcium pump" BROAD [GOC:TermGenie]
synonym: "negative regulation of calcium transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of calcium-translocating P-type ATPase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of plasma membrane Ca-ATPase" NARROW [GOC:TermGenie]
synonym: "negative regulation of sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW [GOC:TermGenie]
synonym: "negative regulation of sarcoplasmic reticulum ATPase" NARROW [GOC:TermGenie]
is_a: GO:0032780 ! negative regulation of ATPase activity
is_a: GO:1901020 ! negative regulation of calcium ion transmembrane transporter activity
is_a: GO:1901894 ! regulation of calcium-transporting ATPase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0005388 ! calcium-transporting ATPase activity
relationship: negatively_regulates GO:0005388 ! calcium-transporting ATPase activity
created_by: rl
creation_date: 2013-02-06T21:18:25Z

[Term]
id: GO:1901896
name: positive regulation of calcium-transporting ATPase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of calcium-transporting ATPase activity." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19708671]
synonym: "activation of ATP phosphohydrolase (Ca2+-transporting)" EXACT [GOC:TermGenie]
synonym: "activation of Ca(2+)-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "activation of Ca2+-pumping ATPase activity" EXACT [GOC:TermGenie]
synonym: "activation of Ca2+-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "activation of calcium ABC transporter" NARROW [GOC:TermGenie]
synonym: "activation of calcium efflux ATPase" NARROW [GOC:TermGenie]
synonym: "activation of calcium pump" BROAD [GOC:TermGenie]
synonym: "activation of calcium transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "activation of calcium-translocating P-type ATPase activity" NARROW [GOC:TermGenie]
synonym: "activation of calcium-transporting ATPase activity" NARROW [GOC:TermGenie]
synonym: "activation of plasma membrane Ca-ATPase" NARROW [GOC:TermGenie]
synonym: "activation of sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW [GOC:TermGenie]
synonym: "activation of sarcoplasmic reticulum ATPase" NARROW [GOC:TermGenie]
synonym: "positive regulation of ATP phosphohydrolase (Ca2+-transporting)" EXACT [GOC:TermGenie]
synonym: "positive regulation of Ca(2+)-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of Ca2+-pumping ATPase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of Ca2+-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of calcium ABC transporter" NARROW [GOC:TermGenie]
synonym: "positive regulation of calcium efflux ATPase" NARROW [GOC:TermGenie]
synonym: "positive regulation of calcium pump" BROAD [GOC:TermGenie]
synonym: "positive regulation of calcium transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of calcium-translocating P-type ATPase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of plasma membrane Ca-ATPase" NARROW [GOC:TermGenie]
synonym: "positive regulation of sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW [GOC:TermGenie]
synonym: "positive regulation of sarcoplasmic reticulum ATPase" NARROW [GOC:TermGenie]
synonym: "up regulation of ATP phosphohydrolase (Ca2+-transporting)" EXACT [GOC:TermGenie]
synonym: "up regulation of Ca(2+)-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of Ca2+-pumping ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of Ca2+-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of calcium ABC transporter" NARROW [GOC:TermGenie]
synonym: "up regulation of calcium efflux ATPase" NARROW [GOC:TermGenie]
synonym: "up regulation of calcium pump" BROAD [GOC:TermGenie]
synonym: "up regulation of calcium transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of calcium-translocating P-type ATPase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of calcium-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of plasma membrane Ca-ATPase" NARROW [GOC:TermGenie]
synonym: "up regulation of sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW [GOC:TermGenie]
synonym: "up regulation of sarcoplasmic reticulum ATPase" NARROW [GOC:TermGenie]
synonym: "up-regulation of ATP phosphohydrolase (Ca2+-transporting)" EXACT [GOC:TermGenie]
synonym: "up-regulation of Ca(2+)-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of Ca2+-pumping ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of Ca2+-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of calcium ABC transporter" NARROW [GOC:TermGenie]
synonym: "up-regulation of calcium efflux ATPase" NARROW [GOC:TermGenie]
synonym: "up-regulation of calcium pump" BROAD [GOC:TermGenie]
synonym: "up-regulation of calcium transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of calcium-translocating P-type ATPase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of calcium-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of plasma membrane Ca-ATPase" NARROW [GOC:TermGenie]
synonym: "up-regulation of sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW [GOC:TermGenie]
synonym: "up-regulation of sarcoplasmic reticulum ATPase" NARROW [GOC:TermGenie]
synonym: "upregulation of ATP phosphohydrolase (Ca2+-transporting)" EXACT [GOC:TermGenie]
synonym: "upregulation of Ca(2+)-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of Ca2+-pumping ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of Ca2+-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of calcium ABC transporter" NARROW [GOC:TermGenie]
synonym: "upregulation of calcium efflux ATPase" NARROW [GOC:TermGenie]
synonym: "upregulation of calcium pump" BROAD [GOC:TermGenie]
synonym: "upregulation of calcium transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of calcium-translocating P-type ATPase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of calcium-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of plasma membrane Ca-ATPase" NARROW [GOC:TermGenie]
synonym: "upregulation of sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW [GOC:TermGenie]
synonym: "upregulation of sarcoplasmic reticulum ATPase" NARROW [GOC:TermGenie]
is_a: GO:0032781 ! positive regulation of ATPase activity
is_a: GO:1901021 ! positive regulation of calcium ion transmembrane transporter activity
is_a: GO:1901894 ! regulation of calcium-transporting ATPase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0005388 ! calcium-transporting ATPase activity
relationship: positively_regulates GO:0005388 ! calcium-transporting ATPase activity
created_by: rl
creation_date: 2013-02-06T21:18:29Z

[Term]
id: GO:1901897
name: regulation of relaxation of cardiac muscle
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of relaxation of cardiac muscle." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19708671]
is_a: GO:1901077 ! regulation of relaxation of muscle
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0055119 ! relaxation of cardiac muscle
relationship: regulates GO:0055119 ! relaxation of cardiac muscle
created_by: rl
creation_date: 2013-02-06T21:26:58Z

[Term]
id: GO:1901898
name: negative regulation of relaxation of cardiac muscle
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of relaxation of cardiac muscle." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19708671]
synonym: "down regulation of relaxation of cardiac muscle" EXACT [GOC:TermGenie]
synonym: "down-regulation of relaxation of cardiac muscle" EXACT [GOC:TermGenie]
synonym: "downregulation of relaxation of cardiac muscle" EXACT [GOC:TermGenie]
synonym: "inhibition of relaxation of cardiac muscle" NARROW [GOC:TermGenie]
is_a: GO:1901078 ! negative regulation of relaxation of muscle
is_a: GO:1901897 ! regulation of relaxation of cardiac muscle
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0055119 ! relaxation of cardiac muscle
relationship: negatively_regulates GO:0055119 ! relaxation of cardiac muscle
created_by: rl
creation_date: 2013-02-06T21:27:02Z

[Term]
id: GO:1901899
name: positive regulation of relaxation of cardiac muscle
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of relaxation of cardiac muscle." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19708671]
synonym: "activation of relaxation of cardiac muscle" NARROW [GOC:TermGenie]
synonym: "up regulation of relaxation of cardiac muscle" EXACT [GOC:TermGenie]
synonym: "up-regulation of relaxation of cardiac muscle" EXACT [GOC:TermGenie]
synonym: "upregulation of relaxation of cardiac muscle" EXACT [GOC:TermGenie]
is_a: GO:1901079 ! positive regulation of relaxation of muscle
is_a: GO:1901897 ! regulation of relaxation of cardiac muscle
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0055119 ! relaxation of cardiac muscle
relationship: positively_regulates GO:0055119 ! relaxation of cardiac muscle
created_by: rl
creation_date: 2013-02-06T21:27:07Z

[Term]
id: GO:1901900
name: regulation of protein localization to cell division site
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to cell division site." [GOC:dph, GOC:TermGenie, PMID:22573892]
synonym: "regulation of protein localisation to cell division site" EXACT [GOC:TermGenie]
is_a: GO:1903827 ! regulation of cellular protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072741 ! protein localization to cell division site
relationship: regulates GO:0072741 ! protein localization to cell division site
created_by: dph
creation_date: 2013-02-11T12:27:55Z

[Term]
id: GO:1901901
name: regulation of protein localization to cell division site involved in cytokinesis
namespace: biological_process
def: "Any regulation of protein localization to cell division site that is involved in cytokinesis." [GOC:dph, GOC:TermGenie, PMID:22573892]
synonym: "regulation of protein localisation to cell division site involved in cytokinesis" EXACT [GOC:TermGenie]
is_a: GO:1901900 ! regulation of protein localization to cell division site
intersection_of: GO:1901900 ! regulation of protein localization to cell division site
intersection_of: part_of GO:0000910 ! cytokinesis
relationship: part_of GO:0000910 ! cytokinesis
created_by: dph
creation_date: 2013-02-12T18:01:34Z

[Term]
id: GO:1901902
name: tyrocidine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tyrocidine." [GOC:TermGenie, GOC:yaf, PMID:9352938]
synonym: "tyrocidine metabolism" EXACT [GOC:TermGenie]
is_a: GO:0008152 ! metabolic process
created_by: yaf
creation_date: 2013-02-12T23:40:29Z

[Term]
id: GO:1901903
name: tyrocidine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tyrocidine." [GOC:TermGenie, GOC:yaf, PMID:9352938]
synonym: "tyrocidine breakdown" EXACT [GOC:TermGenie]
synonym: "tyrocidine catabolism" EXACT [GOC:TermGenie]
synonym: "tyrocidine degradation" EXACT [GOC:TermGenie]
is_a: GO:0009056 ! catabolic process
is_a: GO:1901902 ! tyrocidine metabolic process
created_by: yaf
creation_date: 2013-02-12T23:40:34Z

[Term]
id: GO:1901904
name: tyrocidine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tyrocidine." [GOC:TermGenie, GOC:yaf, PMID:9352938, UniPathway:UPA00180]
synonym: "tyrocidine anabolism" EXACT [GOC:TermGenie]
synonym: "tyrocidine biosynthesis" EXACT [GOC:TermGenie]
synonym: "tyrocidine formation" EXACT [GOC:TermGenie]
synonym: "tyrocidine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009058 ! biosynthetic process
is_a: GO:1901902 ! tyrocidine metabolic process
created_by: yaf
creation_date: 2013-02-12T23:40:43Z

[Term]
id: GO:1901905
name: response to tamsulosin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tamsulosin stimulus." [GOC:TermGenie]
is_a: GO:1901698 ! response to nitrogen compound
created_by: hp
creation_date: 2013-02-13T10:14:41Z

[Term]
id: GO:1901906
name: diadenosine pentaphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving diadenosine pentaphosphate." [GOC:TermGenie, PMID:10090752]
synonym: "diadenosine pentaphosphate metabolism" EXACT [GOC:pr]
synonym: "diadenosyl pentaphosphate metabolic process" EXACT [GOC:pr]
synonym: "diadenosyl pentaphosphate metabolism" EXACT [GOC:TermGenie]
is_a: GO:0015959 ! diadenosine polyphosphate metabolic process
created_by: al
creation_date: 2013-02-13T13:48:16Z

[Term]
id: GO:1901907
name: diadenosine pentaphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of diadenosine pentaphosphate." [GOC:TermGenie, PMID:10090752]
synonym: "diadenosine pentaphosphate catabolism" EXACT [GOC:pr]
synonym: "diadenosyl pentaphosphate breakdown" EXACT [GOC:TermGenie]
synonym: "diadenosyl pentaphosphate catabolic process" EXACT [GOC:pr]
synonym: "diadenosyl pentaphosphate catabolism" EXACT [GOC:TermGenie]
synonym: "diadenosyl pentaphosphate degradation" EXACT [GOC:TermGenie]
is_a: GO:0015961 ! diadenosine polyphosphate catabolic process
is_a: GO:1901906 ! diadenosine pentaphosphate metabolic process
created_by: al
creation_date: 2013-02-13T13:48:21Z

[Term]
id: GO:1901908
name: diadenosine hexaphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving diadenosine hexaphosphate." [GOC:TermGenie, PMID:10090752]
synonym: "diadenosine hexaphosphate metabolism" EXACT [GOC:pr]
synonym: "diadenosyl hexaphosphate metabolic process" EXACT [GOC:pr]
synonym: "diadenosyl hexaphosphate metabolism" EXACT [GOC:TermGenie]
is_a: GO:0015959 ! diadenosine polyphosphate metabolic process
created_by: al
creation_date: 2013-02-13T13:50:40Z

[Term]
id: GO:1901909
name: diadenosine hexaphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of diadenosine hexaphosphate." [GOC:TermGenie, PMID:10090752]
synonym: "diadenosine hexaphosphate catabolism" EXACT [GOC:pr]
synonym: "diadenosyl hexaphosphate breakdown" EXACT [GOC:TermGenie]
synonym: "diadenosyl hexaphosphate catabolic process" EXACT [GOC:pr]
synonym: "diadenosyl hexaphosphate catabolism" EXACT [GOC:TermGenie]
synonym: "diadenosyl hexaphosphate degradation" EXACT [GOC:TermGenie]
is_a: GO:0015961 ! diadenosine polyphosphate catabolic process
is_a: GO:1901908 ! diadenosine hexaphosphate metabolic process
created_by: al
creation_date: 2013-02-13T13:50:44Z

[Term]
id: GO:1901910
name: adenosine 5'-(hexahydrogen pentaphosphate) metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving adenosine 5'-(hexahydrogen pentaphosphate)." [GOC:TermGenie, PMID:10090752]
synonym: "adenosine 5'-(hexahydrogen pentaphosphate) metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009150 ! purine ribonucleotide metabolic process
is_a: GO:0009167 ! purine ribonucleoside monophosphate metabolic process
is_a: GO:0046128 ! purine ribonucleoside metabolic process
created_by: al
creation_date: 2013-02-13T14:17:59Z

[Term]
id: GO:1901911
name: adenosine 5'-(hexahydrogen pentaphosphate) catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of adenosine 5'-(hexahydrogen pentaphosphate)." [GOC:TermGenie, PMID:10090752]
synonym: "adenosine 5'-(hexahydrogen pentaphosphate) breakdown" EXACT [GOC:TermGenie]
synonym: "adenosine 5'-(hexahydrogen pentaphosphate) catabolism" EXACT [GOC:TermGenie]
synonym: "adenosine 5'-(hexahydrogen pentaphosphate) degradation" EXACT [GOC:TermGenie]
is_a: GO:0009154 ! purine ribonucleotide catabolic process
is_a: GO:0009169 ! purine ribonucleoside monophosphate catabolic process
is_a: GO:0046130 ! purine ribonucleoside catabolic process
is_a: GO:1901910 ! adenosine 5'-(hexahydrogen pentaphosphate) metabolic process
created_by: al
creation_date: 2013-02-13T14:18:03Z

[Term]
id: GO:1901913
name: regulation of capsule organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of capsule organization." [GOC:di, GOC:TermGenie]
synonym: "regulation of capsule organisation" EXACT [GOC:TermGenie]
synonym: "regulation of capsule organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045230 ! capsule organization
relationship: regulates GO:0045230 ! capsule organization
created_by: di
creation_date: 2013-02-14T06:19:03Z

[Term]
id: GO:1901914
name: negative regulation of capsule organization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of capsule organization." [GOC:di, GOC:TermGenie]
synonym: "down regulation of capsule organisation" EXACT [GOC:TermGenie]
synonym: "down regulation of capsule organization" EXACT [GOC:TermGenie]
synonym: "down regulation of capsule organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of capsule organisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of capsule organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of capsule organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "downregulation of capsule organisation" EXACT [GOC:TermGenie]
synonym: "downregulation of capsule organization" EXACT [GOC:TermGenie]
synonym: "downregulation of capsule organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "inhibition of capsule organisation" NARROW [GOC:TermGenie]
synonym: "inhibition of capsule organization" NARROW [GOC:TermGenie]
synonym: "inhibition of capsule organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of capsule organisation" EXACT [GOC:TermGenie]
synonym: "negative regulation of capsule organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1901913 ! regulation of capsule organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045230 ! capsule organization
relationship: negatively_regulates GO:0045230 ! capsule organization
created_by: di
creation_date: 2013-02-14T06:19:07Z

[Term]
id: GO:1901915
name: positive regulation of capsule organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of capsule organization." [GOC:di, GOC:TermGenie]
synonym: "activation of capsule organisation" NARROW [GOC:TermGenie]
synonym: "activation of capsule organization" NARROW [GOC:TermGenie]
synonym: "activation of capsule organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of capsule organisation" EXACT [GOC:TermGenie]
synonym: "positive regulation of capsule organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "up regulation of capsule organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of capsule organization" EXACT [GOC:TermGenie]
synonym: "up regulation of capsule organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of capsule organisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of capsule organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of capsule organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "upregulation of capsule organisation" EXACT [GOC:TermGenie]
synonym: "upregulation of capsule organization" EXACT [GOC:TermGenie]
synonym: "upregulation of capsule organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1901913 ! regulation of capsule organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045230 ! capsule organization
relationship: positively_regulates GO:0045230 ! capsule organization
created_by: di
creation_date: 2013-02-14T06:19:16Z

[Term]
id: GO:1901916
name: protein kinase activity involved in regulation of protein localization to cell division site involved in cytokinesis
namespace: molecular_function
def: "Any protein kinase activity that is involved in regulation of protein localization to cell division site involved in cytokinesis." [GOC:dph, GOC:TermGenie, PMID:22573892]
synonym: "protamine kinase activity involved in regulation of protein localisation to cell division site involved in cytokinesis" NARROW [GOC:TermGenie]
synonym: "protamine kinase activity involved in regulation of protein localization to cell division site involved in cytokinesis" NARROW [GOC:TermGenie]
synonym: "protein kinase activity involved in regulation of protein localisation to cell division site involved in cytokinesis" EXACT [GOC:TermGenie]
is_a: GO:0004672 ! protein kinase activity
intersection_of: GO:0004672 ! protein kinase activity
intersection_of: part_of GO:1901901 ! regulation of protein localization to cell division site involved in cytokinesis
relationship: part_of GO:1901901 ! regulation of protein localization to cell division site involved in cytokinesis
created_by: dph
creation_date: 2013-02-14T15:30:37Z

[Term]
id: GO:1901917
name: regulation of exoribonuclease activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of exoribonuclease activity." [GOC:TermGenie, PMID:22570495]
is_a: GO:0060700 ! regulation of ribonuclease activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004532 ! exoribonuclease activity
relationship: regulates GO:0004532 ! exoribonuclease activity
created_by: ramab
creation_date: 2013-02-15T00:57:56Z

[Term]
id: GO:1901918
name: negative regulation of exoribonuclease activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of exoribonuclease activity." [GOC:TermGenie, PMID:22570495]
synonym: "down regulation of exoribonuclease activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of exoribonuclease activity" EXACT [GOC:TermGenie]
synonym: "downregulation of exoribonuclease activity" EXACT [GOC:TermGenie]
synonym: "inhibition of exoribonuclease activity" NARROW [GOC:TermGenie]
is_a: GO:0060701 ! negative regulation of ribonuclease activity
is_a: GO:1901917 ! regulation of exoribonuclease activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004532 ! exoribonuclease activity
relationship: negatively_regulates GO:0004532 ! exoribonuclease activity
created_by: ramab
creation_date: 2013-02-15T00:58:03Z

[Term]
id: GO:1901919
name: positive regulation of exoribonuclease activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of exoribonuclease activity." [GOC:TermGenie, PMID:22570495]
synonym: "activation of exoribonuclease activity" NARROW [GOC:TermGenie]
synonym: "up regulation of exoribonuclease activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of exoribonuclease activity" EXACT [GOC:TermGenie]
synonym: "upregulation of exoribonuclease activity" EXACT [GOC:TermGenie]
is_a: GO:0032075 ! positive regulation of nuclease activity
is_a: GO:0051254 ! positive regulation of RNA metabolic process
is_a: GO:1901917 ! regulation of exoribonuclease activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004532 ! exoribonuclease activity
relationship: positively_regulates GO:0004532 ! exoribonuclease activity
created_by: ramab
creation_date: 2013-02-15T00:58:07Z

[Term]
id: GO:1901920
name: peptidyl-tyrosine dephosphorylation involved in activation of protein kinase activity
namespace: biological_process
def: "Any peptidyl-tyrosine dephosphorylation that is involved in activation of protein kinase activity." [GOC:TermGenie, PMID:1756737]
synonym: "peptidyl-tyrosine dephosphorylation involved in protein kinase activation" RELATED [GOC:TermGenie]
is_a: GO:0035335 ! peptidyl-tyrosine dephosphorylation
intersection_of: GO:0035335 ! peptidyl-tyrosine dephosphorylation
intersection_of: part_of GO:0032147 ! activation of protein kinase activity
relationship: part_of GO:0032147 ! activation of protein kinase activity
created_by: al
creation_date: 2013-02-15T18:54:53Z

[Term]
id: GO:1901921
name: phosphorylation of RNA polymerase II C-terminal domain involved in recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex
namespace: biological_process
def: "Any phosphorylation of RNA polymerase II C-terminal domain that is involved in recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex." [GOC:TermGenie, PMID:10594013]
synonym: "CTD domain phosphorylation of RNA polymerase II involved in recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex" EXACT [GOC:TermGenie]
is_a: GO:0070816 ! phosphorylation of RNA polymerase II C-terminal domain
intersection_of: GO:0070816 ! phosphorylation of RNA polymerase II C-terminal domain
intersection_of: part_of GO:0034402 ! recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex
relationship: part_of GO:0034402 ! recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex
created_by: ramab
creation_date: 2013-02-15T19:09:31Z

[Term]
id: GO:1901922
name: regulation of sclerotium development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sclerotium development." [GOC:di, GOC:TermGenie, PMID:21148914]
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990045 ! sclerotium development
relationship: regulates GO:1990045 ! sclerotium development
created_by: di
creation_date: 2013-02-15T20:00:19Z

[Term]
id: GO:1901923
name: negative regulation of sclerotium development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sclerotium development." [GOC:di, GOC:TermGenie, PMID:21148914]
synonym: "down regulation of sclerotium development" EXACT [GOC:TermGenie]
synonym: "down-regulation of sclerotium development" EXACT [GOC:TermGenie]
synonym: "downregulation of sclerotium development" EXACT [GOC:TermGenie]
synonym: "inhibition of sclerotium development" NARROW [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1901922 ! regulation of sclerotium development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990045 ! sclerotium development
relationship: negatively_regulates GO:1990045 ! sclerotium development
created_by: di
creation_date: 2013-02-15T20:00:23Z

[Term]
id: GO:1901924
name: positive regulation of sclerotium development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sclerotium development." [GOC:di, GOC:TermGenie, PMID:21148914]
synonym: "activation of sclerotium development" NARROW [GOC:TermGenie]
synonym: "up regulation of sclerotium development" EXACT [GOC:TermGenie]
synonym: "up-regulation of sclerotium development" EXACT [GOC:TermGenie]
synonym: "upregulation of sclerotium development" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1901922 ! regulation of sclerotium development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990045 ! sclerotium development
relationship: positively_regulates GO:1990045 ! sclerotium development
created_by: di
creation_date: 2013-02-15T20:00:28Z

[Term]
id: GO:1901925
name: negative regulation of protein import into nucleus during spindle assembly checkpoint
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus, and that occurs as a response to the mitotic cell cycle spindle assembly checkpoint. In S. cerevisiae, this process involves inhibition of the karyopherin/importin Kap121p (also known as Pse1p), which acts as the specific nuclear import receptor for several proteins, including Glc7p. Glc7p functions in opposition to key spindle assembly checkpoint protein Aurora kinase (Ipl1p)." [GOC:dgf, GOC:TermGenie, PMID:23177738]
synonym: "Kap121p transport inhibitory pathway" RELATED []
synonym: "KTIP" RELATED []
synonym: "negative regulation of protein import into nucleus during mitotic cell cycle spindle assembly checkpoint" EXACT []
is_a: GO:0042308 ! negative regulation of protein import into nucleus
is_a: GO:0072479 ! response to mitotic cell cycle spindle assembly checkpoint signaling
created_by: pr
creation_date: 2013-02-17T20:55:16Z

[Term]
id: GO:1901926
name: cadinene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cadinene." [GOC:TermGenie, pmid:22867794]
synonym: "cadinene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0051761 ! sesquiterpene metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
created_by: michel.schneider
creation_date: 2013-02-18T14:54:22Z

[Term]
id: GO:1901927
name: cadinene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cadinene." [GOC:TermGenie, pmid:22867794]
synonym: "cadinene breakdown" EXACT [GOC:TermGenie]
synonym: "cadinene catabolism" EXACT [GOC:TermGenie]
synonym: "cadinene degradation" EXACT [GOC:TermGenie]
is_a: GO:0051763 ! sesquiterpene catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901926 ! cadinene metabolic process
created_by: michel.schneider
creation_date: 2013-02-18T14:54:29Z

[Term]
id: GO:1901928
name: cadinene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cadinene." [GOC:TermGenie, pmid:22867794]
synonym: "cadinene anabolism" EXACT [GOC:TermGenie]
synonym: "cadinene biosynthesis" EXACT [GOC:TermGenie]
synonym: "cadinene formation" EXACT [GOC:TermGenie]
synonym: "cadinene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0051762 ! sesquiterpene biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901926 ! cadinene metabolic process
created_by: michel.schneider
creation_date: 2013-02-18T14:54:34Z

[Term]
id: GO:1901929
name: alpha-copaene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving alpha-copaene." [GOC:TermGenie, pmid:22867794]
synonym: "alpha-copaene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0051761 ! sesquiterpene metabolic process
created_by: michel.schneider
creation_date: 2013-02-18T14:54:39Z

[Term]
id: GO:1901930
name: alpha-copaene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of alpha-copaene." [GOC:TermGenie, pmid:22867794]
synonym: "alpha-copaene breakdown" EXACT [GOC:TermGenie]
synonym: "alpha-copaene catabolism" EXACT [GOC:TermGenie]
synonym: "alpha-copaene degradation" EXACT [GOC:TermGenie]
is_a: GO:0051763 ! sesquiterpene catabolic process
is_a: GO:1901929 ! alpha-copaene metabolic process
created_by: michel.schneider
creation_date: 2013-02-18T14:54:43Z

[Term]
id: GO:1901931
name: alpha-copaene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of alpha-copaene." [GOC:TermGenie, pmid:22867794]
synonym: "alpha-copaene anabolism" EXACT [GOC:TermGenie]
synonym: "alpha-copaene biosynthesis" EXACT [GOC:TermGenie]
synonym: "alpha-copaene formation" EXACT [GOC:TermGenie]
synonym: "alpha-copaene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0051762 ! sesquiterpene biosynthetic process
is_a: GO:1901929 ! alpha-copaene metabolic process
created_by: michel.schneider
creation_date: 2013-02-18T14:54:48Z

[Term]
id: GO:1901932
name: bicyclogermacrene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving bicyclogermacrene." [GOC:TermGenie, pmid:22867794]
synonym: "bicyclogermacrene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0051761 ! sesquiterpene metabolic process
created_by: michel.schneider
creation_date: 2013-02-18T14:54:52Z

[Term]
id: GO:1901933
name: bicyclogermacrene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of bicyclogermacrene." [GOC:TermGenie, pmid:22867794]
synonym: "bicyclogermacrene breakdown" EXACT [GOC:TermGenie]
synonym: "bicyclogermacrene catabolism" EXACT [GOC:TermGenie]
synonym: "bicyclogermacrene degradation" EXACT [GOC:TermGenie]
is_a: GO:0051763 ! sesquiterpene catabolic process
is_a: GO:1901932 ! bicyclogermacrene metabolic process
created_by: michel.schneider
creation_date: 2013-02-18T14:54:57Z

[Term]
id: GO:1901934
name: bicyclogermacrene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of bicyclogermacrene." [GOC:TermGenie, pmid:22867794]
synonym: "bicyclogermacrene anabolism" EXACT [GOC:TermGenie]
synonym: "bicyclogermacrene biosynthesis" EXACT [GOC:TermGenie]
synonym: "bicyclogermacrene formation" EXACT [GOC:TermGenie]
synonym: "bicyclogermacrene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0051762 ! sesquiterpene biosynthetic process
is_a: GO:1901932 ! bicyclogermacrene metabolic process
created_by: michel.schneider
creation_date: 2013-02-18T14:55:01Z

[Term]
id: GO:1901935
name: beta-caryophyllene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving beta-caryophyllene." [GOC:TermGenie, pmid:22867794]
synonym: "beta-caryophyllene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0051761 ! sesquiterpene metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
created_by: michel.schneider
creation_date: 2013-02-18T14:55:06Z

[Term]
id: GO:1901936
name: beta-caryophyllene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of beta-caryophyllene." [GOC:TermGenie, pmid:22867794]
synonym: "beta-caryophyllene breakdown" EXACT [GOC:TermGenie]
synonym: "beta-caryophyllene catabolism" EXACT [GOC:TermGenie]
synonym: "beta-caryophyllene degradation" EXACT [GOC:TermGenie]
is_a: GO:0051763 ! sesquiterpene catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901935 ! beta-caryophyllene metabolic process
created_by: michel.schneider
creation_date: 2013-02-18T14:55:13Z

[Term]
id: GO:1901937
name: beta-caryophyllene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of beta-caryophyllene." [GOC:TermGenie, pmid:22867794]
synonym: "beta-caryophyllene anabolism" EXACT [GOC:TermGenie]
synonym: "beta-caryophyllene biosynthesis" EXACT [GOC:TermGenie]
synonym: "beta-caryophyllene formation" EXACT [GOC:TermGenie]
synonym: "beta-caryophyllene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0051762 ! sesquiterpene biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901935 ! beta-caryophyllene metabolic process
created_by: michel.schneider
creation_date: 2013-02-18T14:55:18Z

[Term]
id: GO:1901938
name: (-)-exo-alpha-bergamotene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (-)-exo-alpha-bergamotene." [GOC:TermGenie, pmid:22867794]
synonym: "(-)-exo-alpha-bergamotene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0051761 ! sesquiterpene metabolic process
is_a: GO:1900673 ! olefin metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
created_by: michel.schneider
creation_date: 2013-02-18T14:55:23Z

[Term]
id: GO:1901939
name: (-)-exo-alpha-bergamotene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of (-)-exo-alpha-bergamotene." [GOC:TermGenie, pmid:22867794]
synonym: "(-)-exo-alpha-bergamotene breakdown" EXACT [GOC:TermGenie]
synonym: "(-)-exo-alpha-bergamotene catabolism" EXACT [GOC:TermGenie]
synonym: "(-)-exo-alpha-bergamotene degradation" EXACT [GOC:TermGenie]
is_a: GO:0051763 ! sesquiterpene catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901938 ! (-)-exo-alpha-bergamotene metabolic process
created_by: michel.schneider
creation_date: 2013-02-18T14:55:27Z

[Term]
id: GO:1901940
name: (-)-exo-alpha-bergamotene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (-)-exo-alpha-bergamotene." [GOC:TermGenie, pmid:22867794]
synonym: "(-)-exo-alpha-bergamotene anabolism" EXACT [GOC:TermGenie]
synonym: "(-)-exo-alpha-bergamotene biosynthesis" EXACT [GOC:TermGenie]
synonym: "(-)-exo-alpha-bergamotene formation" EXACT [GOC:TermGenie]
synonym: "(-)-exo-alpha-bergamotene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0051762 ! sesquiterpene biosynthetic process
is_a: GO:1900674 ! olefin biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901938 ! (-)-exo-alpha-bergamotene metabolic process
created_by: michel.schneider
creation_date: 2013-02-18T14:55:32Z

[Term]
id: GO:1901941
name: (+)-epi-alpha-bisabolol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (+)-epi-alpha-bisabolol." [GOC:TermGenie, pmid:22867794]
synonym: "(+)-epi-alpha-bisabolol metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006714 ! sesquiterpenoid metabolic process
created_by: michel.schneider
creation_date: 2013-02-18T14:55:36Z

[Term]
id: GO:1901942
name: (+)-epi-alpha-bisabolol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of (+)-epi-alpha-bisabolol." [GOC:TermGenie, pmid:22867794]
synonym: "(+)-epi-alpha-bisabolol breakdown" EXACT [GOC:TermGenie]
synonym: "(+)-epi-alpha-bisabolol catabolism" EXACT [GOC:TermGenie]
synonym: "(+)-epi-alpha-bisabolol degradation" EXACT [GOC:TermGenie]
is_a: GO:0016107 ! sesquiterpenoid catabolic process
is_a: GO:1901941 ! (+)-epi-alpha-bisabolol metabolic process
created_by: michel.schneider
creation_date: 2013-02-18T14:55:41Z

[Term]
id: GO:1901943
name: (+)-epi-alpha-bisabolol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (+)-epi-alpha-bisabolol." [GOC:TermGenie, pmid:22867794]
synonym: "(+)-epi-alpha-bisabolol anabolism" EXACT [GOC:TermGenie]
synonym: "(+)-epi-alpha-bisabolol biosynthesis" EXACT [GOC:TermGenie]
synonym: "(+)-epi-alpha-bisabolol formation" EXACT [GOC:TermGenie]
synonym: "(+)-epi-alpha-bisabolol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0016106 ! sesquiterpenoid biosynthetic process
is_a: GO:1901941 ! (+)-epi-alpha-bisabolol metabolic process
created_by: michel.schneider
creation_date: 2013-02-18T14:55:46Z

[Term]
id: GO:1901944
name: miltiradiene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving miltiradiene." [GOC:TermGenie, pmid:22027823]
synonym: "miltiradiene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0042214 ! terpene metabolic process
created_by: michel.schneider
creation_date: 2013-02-18T15:50:23Z

[Term]
id: GO:1901945
name: miltiradiene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of miltiradiene." [GOC:TermGenie, pmid:22027823]
synonym: "miltiradiene breakdown" EXACT [GOC:TermGenie]
synonym: "miltiradiene catabolism" EXACT [GOC:TermGenie]
synonym: "miltiradiene degradation" EXACT [GOC:TermGenie]
is_a: GO:0046247 ! terpene catabolic process
is_a: GO:1901944 ! miltiradiene metabolic process
created_by: michel.schneider
creation_date: 2013-02-18T15:50:27Z

[Term]
id: GO:1901946
name: miltiradiene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of miltiradiene." [GOC:TermGenie, pmid:22027823]
synonym: "miltiradiene anabolism" EXACT [GOC:TermGenie]
synonym: "miltiradiene biosynthesis" EXACT [GOC:TermGenie]
synonym: "miltiradiene formation" EXACT [GOC:TermGenie]
synonym: "miltiradiene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046246 ! terpene biosynthetic process
is_a: GO:1901944 ! miltiradiene metabolic process
created_by: michel.schneider
creation_date: 2013-02-18T15:50:32Z

[Term]
id: GO:1901947
name: 5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate." [GOC:TermGenie, pmid:22027823]
synonym: "5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006644 ! phospholipid metabolic process
is_a: GO:0016101 ! diterpenoid metabolic process
created_by: michel.schneider
creation_date: 2013-02-18T15:50:41Z

[Term]
id: GO:1901948
name: 5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate." [GOC:TermGenie, pmid:22027823]
synonym: "5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate breakdown" EXACT [GOC:TermGenie]
synonym: "5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate catabolism" EXACT [GOC:TermGenie]
synonym: "5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate degradation" EXACT [GOC:TermGenie]
is_a: GO:0009395 ! phospholipid catabolic process
is_a: GO:0016103 ! diterpenoid catabolic process
is_a: GO:1901947 ! 5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate metabolic process
created_by: michel.schneider
creation_date: 2013-02-18T15:50:45Z

[Term]
id: GO:1901949
name: 5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate." [GOC:TermGenie, pmid:22027823]
synonym: "5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate anabolism" EXACT [GOC:TermGenie]
synonym: "5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate biosynthesis" EXACT [GOC:TermGenie]
synonym: "5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate formation" EXACT [GOC:TermGenie]
synonym: "5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate synthesis" EXACT [GOC:TermGenie]
is_a: GO:0008654 ! phospholipid biosynthetic process
is_a: GO:0016102 ! diterpenoid biosynthetic process
is_a: GO:1901947 ! 5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate metabolic process
created_by: michel.schneider
creation_date: 2013-02-18T15:50:50Z

[Term]
id: GO:1901950
name: dense core granule transport
namespace: biological_process
def: "The directed movement a dense core granule within a cell." [GOC:kmv, GOC:TermGenie, PMID:23358451]
synonym: "dense core vesicle transport" EXACT [GOC:TermGenie]
is_a: GO:0016482 ! cytosolic transport
is_a: GO:0032253 ! dense core granule localization
is_a: GO:0051650 ! establishment of vesicle localization
relationship: occurs_in GO:0005829 ! cytosol
created_by: pr
creation_date: 2013-02-19T13:00:52Z

[Term]
id: GO:1901951
name: regulation of anterograde dense core granule transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of anterograde dense core granule transport." [GOC:kmv, GOC:TermGenie, PMID:23358451]
is_a: GO:1901608 ! regulation of vesicle transport along microtubule
is_a: GO:1904809 ! regulation of dense core granule transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990048 ! anterograde dense core granule trafficking
relationship: regulates GO:1990048 ! anterograde dense core granule trafficking
created_by: pr
creation_date: 2013-02-19T13:36:21Z

[Term]
id: GO:1901952
name: negative regulation of anterograde dense core granule transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of anterograde dense core granule transport." [GOC:kmv, GOC:TermGenie, PMID:23358451]
synonym: "down regulation of anterograde dense core granule transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of anterograde dense core granule transport" EXACT [GOC:TermGenie]
synonym: "downregulation of anterograde dense core granule transport" EXACT [GOC:TermGenie]
synonym: "inhibition of anterograde dense core granule transport" NARROW [GOC:TermGenie]
is_a: GO:1901609 ! negative regulation of vesicle transport along microtubule
is_a: GO:1901951 ! regulation of anterograde dense core granule transport
is_a: GO:1904810 ! negative regulation of dense core granule transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990048 ! anterograde dense core granule trafficking
relationship: negatively_regulates GO:1990048 ! anterograde dense core granule trafficking
created_by: pr
creation_date: 2013-02-19T13:36:30Z

[Term]
id: GO:1901953
name: positive regulation of anterograde dense core granule transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of anterograde dense core granule transport." [GOC:kmv, GOC:TermGenie, PMID:23358451]
synonym: "activation of anterograde dense core granule transport" NARROW [GOC:TermGenie]
synonym: "up regulation of anterograde dense core granule transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of anterograde dense core granule transport" EXACT [GOC:TermGenie]
synonym: "upregulation of anterograde dense core granule transport" EXACT [GOC:TermGenie]
is_a: GO:1901610 ! positive regulation of vesicle transport along microtubule
is_a: GO:1901951 ! regulation of anterograde dense core granule transport
is_a: GO:1904811 ! positive regulation of dense core granule transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990048 ! anterograde dense core granule trafficking
relationship: positively_regulates GO:1990048 ! anterograde dense core granule trafficking
created_by: pr
creation_date: 2013-02-19T13:36:35Z

[Term]
id: GO:1901954
name: regulation of retrograde dense core granule transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of retrograde dense core granule transport." [GOC:kmv, GOC:TermGenie, PMID:23358451]
is_a: GO:1901608 ! regulation of vesicle transport along microtubule
is_a: GO:1904809 ! regulation of dense core granule transport
is_a: GO:2001017 ! regulation of retrograde axon cargo transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990049 ! retrograde dense core granule trafficking
relationship: regulates GO:1990049 ! retrograde dense core granule trafficking
created_by: pr
creation_date: 2013-02-19T13:36:43Z

[Term]
id: GO:1901955
name: negative regulation of retrograde dense core granule transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of retrograde dense core granule transport." [GOC:kmv, GOC:TermGenie, PMID:23358451]
synonym: "down regulation of retrograde dense core granule transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of retrograde dense core granule transport" EXACT [GOC:TermGenie]
synonym: "downregulation of retrograde dense core granule transport" EXACT [GOC:TermGenie]
synonym: "inhibition of retrograde dense core granule transport" NARROW [GOC:TermGenie]
is_a: GO:1901609 ! negative regulation of vesicle transport along microtubule
is_a: GO:1901954 ! regulation of retrograde dense core granule transport
is_a: GO:1904810 ! negative regulation of dense core granule transport
is_a: GO:2001018 ! negative regulation of retrograde axon cargo transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990049 ! retrograde dense core granule trafficking
relationship: negatively_regulates GO:1990049 ! retrograde dense core granule trafficking
created_by: pr
creation_date: 2013-02-19T13:36:47Z

[Term]
id: GO:1901956
name: positive regulation of retrograde dense core granule transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of retrograde dense core granule transport." [GOC:kmv, GOC:TermGenie, PMID:23358451]
synonym: "activation of retrograde dense core granule transport" NARROW [GOC:TermGenie]
synonym: "up regulation of retrograde dense core granule transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of retrograde dense core granule transport" EXACT [GOC:TermGenie]
synonym: "upregulation of retrograde dense core granule transport" EXACT [GOC:TermGenie]
is_a: GO:1901610 ! positive regulation of vesicle transport along microtubule
is_a: GO:1901954 ! regulation of retrograde dense core granule transport
is_a: GO:1904811 ! positive regulation of dense core granule transport
is_a: GO:2001019 ! positive regulation of retrograde axon cargo transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990049 ! retrograde dense core granule trafficking
relationship: positively_regulates GO:1990049 ! retrograde dense core granule trafficking
created_by: pr
creation_date: 2013-02-19T13:36:52Z

[Term]
id: GO:1901957
name: regulation of cutin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cutin biosynthetic process." [GOC:tb, GOC:TermGenie, PMID:23243127]
synonym: "regulation of cutin anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of cutin biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of cutin formation" EXACT [GOC:TermGenie]
synonym: "regulation of cutin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010143 ! cutin biosynthetic process
relationship: regulates GO:0010143 ! cutin biosynthetic process
created_by: tb
creation_date: 2013-02-19T19:06:06Z

[Term]
id: GO:1901958
name: negative regulation of cutin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cutin biosynthetic process." [GOC:tb, GOC:TermGenie, PMID:23243127]
synonym: "down regulation of cutin anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of cutin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of cutin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of cutin formation" EXACT [GOC:TermGenie]
synonym: "down regulation of cutin synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of cutin anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of cutin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of cutin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of cutin formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of cutin synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of cutin anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of cutin biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of cutin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of cutin formation" EXACT [GOC:TermGenie]
synonym: "downregulation of cutin synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of cutin anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of cutin biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of cutin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of cutin formation" EXACT [GOC:TermGenie]
synonym: "inhibition of cutin synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of cutin anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of cutin biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of cutin formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of cutin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
is_a: GO:1901957 ! regulation of cutin biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010143 ! cutin biosynthetic process
relationship: negatively_regulates GO:0010143 ! cutin biosynthetic process
created_by: tb
creation_date: 2013-02-19T19:06:10Z

[Term]
id: GO:1901959
name: positive regulation of cutin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cutin biosynthetic process." [GOC:tb, GOC:TermGenie, PMID:23243127]
synonym: "activation of cutin anabolism" EXACT [GOC:TermGenie]
synonym: "activation of cutin biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of cutin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of cutin formation" EXACT [GOC:TermGenie]
synonym: "activation of cutin synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of cutin anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of cutin biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of cutin formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of cutin synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of cutin anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of cutin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of cutin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of cutin formation" EXACT [GOC:TermGenie]
synonym: "up regulation of cutin synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of cutin anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of cutin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of cutin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of cutin formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of cutin synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of cutin anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of cutin biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of cutin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of cutin formation" EXACT [GOC:TermGenie]
synonym: "upregulation of cutin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:1901957 ! regulation of cutin biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010143 ! cutin biosynthetic process
relationship: positively_regulates GO:0010143 ! cutin biosynthetic process
created_by: tb
creation_date: 2013-02-19T19:06:19Z

[Term]
id: GO:1901960
name: isobutanol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving isobutanol." [GOC:mengo_curators, GOC:TermGenie, PMID:22224870]
synonym: "isobutanol metabolism" EXACT [GOC:TermGenie]
is_a: GO:0034308 ! primary alcohol metabolic process
created_by: tt
creation_date: 2013-02-19T21:49:44Z

[Term]
id: GO:1901961
name: isobutanol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of isobutanol." [GOC:mengo_curators, GOC:TermGenie, PMID:22224870]
synonym: "isobutanol anabolism" EXACT [GOC:TermGenie]
synonym: "isobutanol biosynthesis" EXACT [GOC:TermGenie]
synonym: "isobutanol formation" EXACT [GOC:TermGenie]
synonym: "isobutanol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0034309 ! primary alcohol biosynthetic process
is_a: GO:1901960 ! isobutanol metabolic process
created_by: tt
creation_date: 2013-02-19T21:49:49Z

[Term]
id: GO:1901962
name: S-adenosyl-L-methionine transmembrane transport
namespace: biological_process
def: "The directed movement of S-adenosyl-L-methionine across a membrane." [GOC:TermGenie, PMID:10497160]
synonym: "S-adenosylmethionine transmembrane transport" EXACT []
synonym: "SAM transmembrane transport" EXACT []
is_a: GO:0003333 ! amino acid transmembrane transport
is_a: GO:0015805 ! S-adenosyl-L-methionine transport
is_a: GO:0015860 ! purine nucleoside transmembrane transport
created_by: jl
creation_date: 2013-02-20T14:45:08Z

[Term]
id: GO:1901963
name: regulation of cell proliferation involved in outflow tract morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell proliferation involved in outflow tract morphogenesis." [GOC:dph, GOC:mtg_heart, GOC:TermGenie, PMID:21419760]
is_a: GO:2000136 ! regulation of cell proliferation involved in heart morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061325 ! cell proliferation involved in outflow tract morphogenesis
relationship: regulates GO:0061325 ! cell proliferation involved in outflow tract morphogenesis
created_by: dph
creation_date: 2013-02-20T20:30:26Z

[Term]
id: GO:1901964
name: positive regulation of cell proliferation involved in outflow tract morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in outflow tract morphogenesis." [GOC:dph, GOC:mtg_heart, GOC:TermGenie, PMID:21419760]
synonym: "activation of cell proliferation involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
synonym: "up regulation of cell proliferation involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell proliferation involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of cell proliferation involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:1901963 ! regulation of cell proliferation involved in outflow tract morphogenesis
is_a: GO:2000138 ! positive regulation of cell proliferation involved in heart morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061325 ! cell proliferation involved in outflow tract morphogenesis
relationship: positively_regulates GO:0061325 ! cell proliferation involved in outflow tract morphogenesis
created_by: dph
creation_date: 2013-02-20T20:30:31Z

[Term]
id: GO:1901965
name: endoplasmic reticulum to chloroplast transport
namespace: biological_process
def: "The directed movement of substances from endoplasmic reticulum to chloroplast." [GOC:TermGenie, PMID:18689504]
synonym: "ER to chloroplast transport" EXACT [GOC:TermGenie]
is_a: GO:0046907 ! intracellular transport
created_by: tb
creation_date: 2013-02-20T23:48:52Z

[Term]
id: GO:1901966
name: regulation of cellular response to iron ion starvation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular response to iron ion starvation." [GOC:TermGenie, PMID:23115244]
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0032107 ! regulation of response to nutrient levels
is_a: GO:0080135 ! regulation of cellular response to stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010106 ! cellular response to iron ion starvation
relationship: regulates GO:0010106 ! cellular response to iron ion starvation
created_by: al
creation_date: 2013-02-21T11:35:57Z

[Term]
id: GO:1901967
name: negative regulation of cellular response to iron ion starvation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to iron ion starvation." [GOC:TermGenie, PMID:23115244]
synonym: "down regulation of cellular response to iron ion starvation" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular response to iron ion starvation" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular response to iron ion starvation" EXACT [GOC:TermGenie]
synonym: "inhibition of cellular response to iron ion starvation" NARROW [GOC:TermGenie]
is_a: GO:0010648 ! negative regulation of cell communication
is_a: GO:0032108 ! negative regulation of response to nutrient levels
is_a: GO:1901966 ! regulation of cellular response to iron ion starvation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010106 ! cellular response to iron ion starvation
relationship: negatively_regulates GO:0010106 ! cellular response to iron ion starvation
created_by: al
creation_date: 2013-02-21T11:36:02Z

[Term]
id: GO:1901968
name: regulation of polynucleotide 3'-phosphatase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of polynucleotide 3'-phosphatase activity." [GOC:TermGenie, PMID:23316050]
synonym: "regulation of 2'(3')-polynucleotidase activity" EXACT [GOC:TermGenie]
synonym: "regulation of 5'-polynucleotidekinase 3'-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "regulation of deoxyribonucleate 3'-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "regulation of DNA 3'-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "regulation of polynucleotide 3'-phosphohydrolase activity" EXACT [GOC:TermGenie]
is_a: GO:0010921 ! regulation of phosphatase activity
is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0046403 ! polynucleotide 3'-phosphatase activity
relationship: regulates GO:0046403 ! polynucleotide 3'-phosphatase activity
created_by: tb
creation_date: 2013-02-22T00:58:17Z

[Term]
id: GO:1901969
name: positive regulation of polynucleotide 3'-phosphatase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of polynucleotide 3'-phosphatase activity." [GOC:TermGenie, PMID:23316050]
synonym: "activation of 2'(3')-polynucleotidase activity" EXACT [GOC:TermGenie]
synonym: "activation of 5'-polynucleotidekinase 3'-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "activation of deoxyribonucleate 3'-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "activation of DNA 3'-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "activation of polynucleotide 3'-phosphatase activity" NARROW [GOC:TermGenie]
synonym: "activation of polynucleotide 3'-phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of 2'(3')-polynucleotidase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of 5'-polynucleotidekinase 3'-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of deoxyribonucleate 3'-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of DNA 3'-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of polynucleotide 3'-phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of 2'(3')-polynucleotidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of 5'-polynucleotidekinase 3'-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of deoxyribonucleate 3'-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA 3'-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of polynucleotide 3'-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of polynucleotide 3'-phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of 2'(3')-polynucleotidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of 5'-polynucleotidekinase 3'-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of deoxyribonucleate 3'-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA 3'-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of polynucleotide 3'-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of polynucleotide 3'-phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of 2'(3')-polynucleotidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of 5'-polynucleotidekinase 3'-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of deoxyribonucleate 3'-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA 3'-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of polynucleotide 3'-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of polynucleotide 3'-phosphohydrolase activity" EXACT [GOC:TermGenie]
is_a: GO:0010922 ! positive regulation of phosphatase activity
is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process
is_a: GO:1901968 ! regulation of polynucleotide 3'-phosphatase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0046403 ! polynucleotide 3'-phosphatase activity
relationship: positively_regulates GO:0046403 ! polynucleotide 3'-phosphatase activity
created_by: tb
creation_date: 2013-02-22T00:58:31Z

[Term]
id: GO:1901970
name: positive regulation of mitotic sister chromatid separation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitotic sister chromatid separation." [GOC:TermGenie, PMID:1846086]
synonym: "activation of chromosome separation during mitosis" RELATED [GOC:TermGenie]
synonym: "activation of mitotic chromosome separation" RELATED [GOC:TermGenie]
synonym: "activation of mitotic sister chromatid resolution" EXACT [GOC:TermGenie]
synonym: "activation of mitotic sister chromatid separation" NARROW [GOC:TermGenie]
synonym: "activation of sister chromatid separation during mitosis" EXACT [GOC:TermGenie]
synonym: "positive regulation of chromosome separation during mitosis" RELATED [GOC:TermGenie]
synonym: "positive regulation of mitotic chromosome separation" RELATED [GOC:TermGenie]
synonym: "positive regulation of mitotic sister chromatid resolution" EXACT [GOC:TermGenie]
synonym: "positive regulation of sister chromatid separation during mitosis" EXACT [GOC:TermGenie]
synonym: "up regulation of chromosome separation during mitosis" RELATED [GOC:TermGenie]
synonym: "up regulation of mitotic chromosome separation" RELATED [GOC:TermGenie]
synonym: "up regulation of mitotic sister chromatid resolution" EXACT [GOC:TermGenie]
synonym: "up regulation of mitotic sister chromatid separation" EXACT [GOC:TermGenie]
synonym: "up regulation of sister chromatid separation during mitosis" EXACT [GOC:TermGenie]
synonym: "up-regulation of chromosome separation during mitosis" RELATED [GOC:TermGenie]
synonym: "up-regulation of mitotic chromosome separation" RELATED [GOC:TermGenie]
synonym: "up-regulation of mitotic sister chromatid resolution" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitotic sister chromatid separation" EXACT [GOC:TermGenie]
synonym: "up-regulation of sister chromatid separation during mitosis" EXACT [GOC:TermGenie]
synonym: "upregulation of chromosome separation during mitosis" RELATED [GOC:TermGenie]
synonym: "upregulation of mitotic chromosome separation" RELATED [GOC:TermGenie]
synonym: "upregulation of mitotic sister chromatid resolution" EXACT [GOC:TermGenie]
synonym: "upregulation of mitotic sister chromatid separation" EXACT [GOC:TermGenie]
synonym: "upregulation of sister chromatid separation during mitosis" EXACT [GOC:TermGenie]
is_a: GO:0010965 ! regulation of mitotic sister chromatid separation
is_a: GO:0045840 ! positive regulation of mitotic nuclear division
is_a: GO:0051984 ! positive regulation of chromosome segregation
is_a: GO:2001252 ! positive regulation of chromosome organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051306 ! mitotic sister chromatid separation
relationship: positively_regulates GO:0051306 ! mitotic sister chromatid separation
created_by: al
creation_date: 2013-02-22T19:06:19Z

[Term]
id: GO:1901971
name: regulation of DNA-5-methylcytosine glycosylase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA-5-methylcytosine glycosylase activity." [GOC:TermGenie, PMID:23316050]
is_a: GO:1902544 ! regulation of DNA N-glycosylase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990053 ! DNA-5-methylcytosine glycosylase activity
relationship: regulates GO:1990053 ! DNA-5-methylcytosine glycosylase activity
created_by: tb
creation_date: 2013-02-25T20:01:29Z

[Term]
id: GO:1901972
name: positive regulation of DNA-5-methylcytosine glycosylase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA-5-methylcytosine glycosylase activity." [GOC:TermGenie, PMID:23316050]
synonym: "activation of DNA-5-methylcytosine glycosylase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of DNA-5-methylcytosine glycosylase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA-5-methylcytosine glycosylase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA-5-methylcytosine glycosylase activity" EXACT [GOC:TermGenie]
is_a: GO:1901971 ! regulation of DNA-5-methylcytosine glycosylase activity
is_a: GO:1902546 ! positive regulation of DNA N-glycosylase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990053 ! DNA-5-methylcytosine glycosylase activity
relationship: positively_regulates GO:1990053 ! DNA-5-methylcytosine glycosylase activity
created_by: tb
creation_date: 2013-02-25T20:01:34Z

[Term]
id: GO:1901973
name: proline binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with proline." [GOC:pm, GOC:TermGenie, PMID:7730362]
is_a: GO:0016597 ! amino acid binding
is_a: GO:0043169 ! cation binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding
created_by: pm
creation_date: 2013-02-26T14:58:01Z

[Term]
id: GO:1901974
name: glycerate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of glycerate from one side of the membrane to the other." [GOC:TermGenie, pmid:23382251]
is_a: GO:0042879 ! aldonate transmembrane transporter activity
relationship: part_of GO:1901975 ! glycerate transmembrane transport
created_by: michel.schneider
creation_date: 2013-03-05T16:48:45Z

[Term]
id: GO:1901975
name: glycerate transmembrane transport
namespace: biological_process
def: "The directed movement of glycerate across a membrane." [GOC:TermGenie, pmid:23382251]
is_a: GO:0034219 ! carbohydrate transmembrane transport
is_a: GO:0042873 ! aldonate transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport
created_by: michel.schneider
creation_date: 2013-03-05T16:48:50Z

[Term]
id: GO:1901976
name: regulation of cell cycle checkpoint
namespace: biological_process
alt_id: GO:2001047
def: "Any process that modulates the frequency, rate or extent of cell cycle checkpoint." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:23028116]
comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of checkpoint (i.e mitotic spindle or DNA damage etc).
subset: gocheck_do_not_manually_annotate
synonym: "regulation of G1/S checkpoint" RELATED [GOC:obol]
synonym: "regulation of G1/S transition checkpoint" RELATED []
is_a: GO:0010564 ! regulation of cell cycle process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000075 ! cell cycle checkpoint
relationship: regulates GO:0000075 ! cell cycle checkpoint
created_by: jl
creation_date: 2013-03-06T15:10:20Z

[Term]
id: GO:1901977
name: negative regulation of cell cycle checkpoint
namespace: biological_process
alt_id: GO:2001048
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle checkpoint." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:23028116]
comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of checkpoint (i.e mitotic spindle or DNA damage etc).
subset: gocheck_do_not_manually_annotate
synonym: "down regulation of cell cycle checkpoint" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell cycle checkpoint" EXACT [GOC:TermGenie]
synonym: "downregulation of cell cycle checkpoint" EXACT [GOC:TermGenie]
synonym: "inhibition of cell cycle checkpoint" NARROW [GOC:TermGenie]
synonym: "negative regulation of G1/S checkpoint" RELATED [GOC:obol]
synonym: "negative regulation of G1/S transition checkpoint" RELATED []
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:1901976 ! regulation of cell cycle checkpoint
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000075 ! cell cycle checkpoint
relationship: negatively_regulates GO:0000075 ! cell cycle checkpoint
created_by: jl
creation_date: 2013-03-06T15:10:29Z

[Term]
id: GO:1901978
name: positive regulation of cell cycle checkpoint
namespace: biological_process
alt_id: GO:2001052
def: "Any process that activates or increases the frequency, rate or extent of cell cycle checkpoint." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:23028116]
synonym: "activation of cell cycle checkpoint" NARROW [GOC:TermGenie]
synonym: "positive regulation of G1/S checkpoint" RELATED [GOC:obol]
synonym: "positive regulation of G1/S transition checkpoint" RELATED []
synonym: "up regulation of cell cycle checkpoint" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell cycle checkpoint" EXACT [GOC:TermGenie]
synonym: "upregulation of cell cycle checkpoint" EXACT [GOC:TermGenie]
is_a: GO:0090068 ! positive regulation of cell cycle process
is_a: GO:1901976 ! regulation of cell cycle checkpoint
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000075 ! cell cycle checkpoint
relationship: positively_regulates GO:0000075 ! cell cycle checkpoint
created_by: jl
creation_date: 2013-03-06T15:10:34Z

[Term]
id: GO:1901979
name: regulation of inward rectifier potassium channel activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of inward rectifier potassium channel activity." [GOC:TermGenie, PMID:23449501]
synonym: "regulation of Kir channel activity" EXACT [GOC:TermGenie]
is_a: GO:0010469 ! regulation of receptor activity
is_a: GO:1901016 ! regulation of potassium ion transmembrane transporter activity
is_a: GO:2001257 ! regulation of cation channel activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0005242 ! inward rectifier potassium channel activity
relationship: regulates GO:0005242 ! inward rectifier potassium channel activity
created_by: tb
creation_date: 2013-03-12T18:21:12Z

[Term]
id: GO:1901980
name: positive regulation of inward rectifier potassium channel activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of inward rectifier potassium channel activity." [GOC:TermGenie, PMID:23449501]
synonym: "activation of inward rectifier potassium channel activity" NARROW [GOC:TermGenie]
synonym: "activation of Kir channel activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of Kir channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of Kir channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of Kir channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of Kir channel activity" EXACT [GOC:TermGenie]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:1901979 ! regulation of inward rectifier potassium channel activity
is_a: GO:1903818 ! positive regulation of voltage-gated potassium channel activity
is_a: GO:2000273 ! positive regulation of receptor activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0005242 ! inward rectifier potassium channel activity
relationship: positively_regulates GO:0005242 ! inward rectifier potassium channel activity
created_by: tb
creation_date: 2013-03-12T18:21:17Z

[Term]
id: GO:1901981
name: phosphatidylinositol phosphate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with phosphatidylinositol phosphate." [GOC:TermGenie, PMID:23445487]
is_a: GO:0035091 ! phosphatidylinositol binding
created_by: tb
creation_date: 2013-03-12T18:21:22Z

[Term]
id: GO:1901982
name: maltose binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with maltose." [GOC:TermGenie, PMID:21566157]
is_a: GO:0048030 ! disaccharide binding
created_by: tb
creation_date: 2013-03-13T18:17:19Z

[Term]
id: GO:1901983
name: regulation of protein acetylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein acetylation." [GOC:TermGenie, PMID:22117195]
synonym: "regulation of protein amino acid acetylation" EXACT [GOC:TermGenie]
is_a: GO:0031399 ! regulation of protein modification process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006473 ! protein acetylation
relationship: regulates GO:0006473 ! protein acetylation
created_by: ss
creation_date: 2013-03-14T00:40:07Z

[Term]
id: GO:1901984
name: negative regulation of protein acetylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein acetylation." [GOC:TermGenie, PMID:22117195]
synonym: "down regulation of protein acetylation" EXACT [GOC:TermGenie]
synonym: "down regulation of protein amino acid acetylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein acetylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein amino acid acetylation" EXACT [GOC:TermGenie]
synonym: "downregulation of protein acetylation" EXACT [GOC:TermGenie]
synonym: "downregulation of protein amino acid acetylation" EXACT [GOC:TermGenie]
synonym: "inhibition of protein acetylation" NARROW [GOC:TermGenie]
synonym: "inhibition of protein amino acid acetylation" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein amino acid acetylation" EXACT [GOC:TermGenie]
is_a: GO:0031400 ! negative regulation of protein modification process
is_a: GO:1901983 ! regulation of protein acetylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006473 ! protein acetylation
relationship: negatively_regulates GO:0006473 ! protein acetylation
created_by: ss
creation_date: 2013-03-14T00:40:11Z

[Term]
id: GO:1901985
name: positive regulation of protein acetylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein acetylation." [GOC:TermGenie, PMID:22117195]
synonym: "activation of protein acetylation" NARROW [GOC:TermGenie]
synonym: "activation of protein amino acid acetylation" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein amino acid acetylation" EXACT [GOC:TermGenie]
synonym: "up regulation of protein acetylation" EXACT [GOC:TermGenie]
synonym: "up regulation of protein amino acid acetylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein acetylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein amino acid acetylation" EXACT [GOC:TermGenie]
synonym: "upregulation of protein acetylation" EXACT [GOC:TermGenie]
synonym: "upregulation of protein amino acid acetylation" EXACT [GOC:TermGenie]
is_a: GO:0031401 ! positive regulation of protein modification process
is_a: GO:1901983 ! regulation of protein acetylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006473 ! protein acetylation
relationship: positively_regulates GO:0006473 ! protein acetylation
created_by: ss
creation_date: 2013-03-14T00:40:19Z

[Term]
id: GO:1901986
name: response to ketamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketamine stimulus." [GOC:TermGenie, PMID:11251190]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901654 ! response to ketone
created_by: dph
creation_date: 2013-03-15T19:16:35Z

[Term]
id: GO:1901987
name: regulation of cell cycle phase transition
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721]
synonym: "cell cycle control" EXACT [GOC:vw]
synonym: "regulation of cell cycle transition" EXACT [GOC:TermGenie]
is_a: GO:0010564 ! regulation of cell cycle process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044770 ! cell cycle phase transition
relationship: regulates GO:0044770 ! cell cycle phase transition
created_by: jl
creation_date: 2013-03-19T16:11:27Z

[Term]
id: GO:1901988
name: negative regulation of cell cycle phase transition
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721]
synonym: "down regulation of cell cycle phase transition" EXACT [GOC:TermGenie]
synonym: "down regulation of cell cycle transition" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell cycle phase transition" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell cycle transition" EXACT [GOC:TermGenie]
synonym: "downregulation of cell cycle phase transition" EXACT [GOC:TermGenie]
synonym: "downregulation of cell cycle transition" EXACT [GOC:TermGenie]
synonym: "inhibition of cell cycle phase transition" NARROW [GOC:TermGenie]
synonym: "inhibition of cell cycle transition" EXACT [GOC:TermGenie]
synonym: "negative regulation of cell cycle transition" EXACT [GOC:TermGenie]
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:1901987 ! regulation of cell cycle phase transition
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044770 ! cell cycle phase transition
relationship: negatively_regulates GO:0044770 ! cell cycle phase transition
created_by: jl
creation_date: 2013-03-19T16:11:32Z

[Term]
id: GO:1901989
name: positive regulation of cell cycle phase transition
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721]
synonym: "activation of cell cycle phase transition" NARROW [GOC:TermGenie]
synonym: "activation of cell cycle transition" EXACT [GOC:TermGenie]
synonym: "positive regulation of cell cycle transition" EXACT [GOC:TermGenie]
synonym: "up regulation of cell cycle phase transition" EXACT [GOC:TermGenie]
synonym: "up regulation of cell cycle transition" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell cycle phase transition" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell cycle transition" EXACT [GOC:TermGenie]
synonym: "upregulation of cell cycle phase transition" EXACT [GOC:TermGenie]
synonym: "upregulation of cell cycle transition" EXACT [GOC:TermGenie]
is_a: GO:0090068 ! positive regulation of cell cycle process
is_a: GO:1901987 ! regulation of cell cycle phase transition
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044770 ! cell cycle phase transition
relationship: positively_regulates GO:0044770 ! cell cycle phase transition
created_by: jl
creation_date: 2013-03-19T16:11:37Z

[Term]
id: GO:1901990
name: regulation of mitotic cell cycle phase transition
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721]
synonym: "mitotic cell cycle control" EXACT [GOC:vw]
is_a: GO:0007346 ! regulation of mitotic cell cycle
is_a: GO:1901987 ! regulation of cell cycle phase transition
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044772 ! mitotic cell cycle phase transition
relationship: regulates GO:0044772 ! mitotic cell cycle phase transition
created_by: jl
creation_date: 2013-03-19T16:14:38Z

[Term]
id: GO:1901991
name: negative regulation of mitotic cell cycle phase transition
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721]
synonym: "down regulation of mitotic cell cycle phase transition" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitotic cell cycle phase transition" EXACT [GOC:TermGenie]
synonym: "downregulation of mitotic cell cycle phase transition" EXACT [GOC:TermGenie]
synonym: "inhibition of mitotic cell cycle phase transition" NARROW [GOC:TermGenie]
is_a: GO:0045930 ! negative regulation of mitotic cell cycle
is_a: GO:1901988 ! negative regulation of cell cycle phase transition
is_a: GO:1901990 ! regulation of mitotic cell cycle phase transition
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044772 ! mitotic cell cycle phase transition
relationship: negatively_regulates GO:0044772 ! mitotic cell cycle phase transition
created_by: jl
creation_date: 2013-03-19T16:14:46Z

[Term]
id: GO:1901992
name: positive regulation of mitotic cell cycle phase transition
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721]
synonym: "activation of mitotic cell cycle phase transition" NARROW [GOC:TermGenie]
synonym: "up regulation of mitotic cell cycle phase transition" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitotic cell cycle phase transition" EXACT [GOC:TermGenie]
synonym: "upregulation of mitotic cell cycle phase transition" EXACT [GOC:TermGenie]
is_a: GO:0045931 ! positive regulation of mitotic cell cycle
is_a: GO:1901989 ! positive regulation of cell cycle phase transition
is_a: GO:1901990 ! regulation of mitotic cell cycle phase transition
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044772 ! mitotic cell cycle phase transition
relationship: positively_regulates GO:0044772 ! mitotic cell cycle phase transition
created_by: jl
creation_date: 2013-03-19T16:14:51Z

[Term]
id: GO:1901993
name: regulation of meiotic cell cycle phase transition
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of meiotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721]
synonym: "meiotic cell cycle control" EXACT [GOC:vw]
synonym: "regulation of cell cycle transition" BROAD [GOC:TermGenie]
is_a: GO:0051445 ! regulation of meiotic cell cycle
is_a: GO:1901987 ! regulation of cell cycle phase transition
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044771 ! meiotic cell cycle phase transition
relationship: regulates GO:0044771 ! meiotic cell cycle phase transition
created_by: jl
creation_date: 2013-03-19T16:14:58Z

[Term]
id: GO:1901994
name: negative regulation of meiotic cell cycle phase transition
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of meiotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721]
synonym: "down regulation of cell cycle transition" BROAD [GOC:TermGenie]
synonym: "down regulation of meiotic cell cycle phase transition" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell cycle transition" BROAD [GOC:TermGenie]
synonym: "down-regulation of meiotic cell cycle phase transition" EXACT [GOC:TermGenie]
synonym: "downregulation of cell cycle transition" BROAD [GOC:TermGenie]
synonym: "downregulation of meiotic cell cycle phase transition" EXACT [GOC:TermGenie]
synonym: "inhibition of cell cycle transition" BROAD [GOC:TermGenie]
synonym: "inhibition of meiotic cell cycle phase transition" NARROW [GOC:TermGenie]
synonym: "negative regulation of cell cycle transition" BROAD [GOC:TermGenie]
is_a: GO:0051447 ! negative regulation of meiotic cell cycle
is_a: GO:1901988 ! negative regulation of cell cycle phase transition
is_a: GO:1901993 ! regulation of meiotic cell cycle phase transition
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044771 ! meiotic cell cycle phase transition
relationship: negatively_regulates GO:0044771 ! meiotic cell cycle phase transition
created_by: jl
creation_date: 2013-03-19T16:15:03Z

[Term]
id: GO:1901995
name: positive regulation of meiotic cell cycle phase transition
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of meiotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721]
synonym: "activation of cell cycle transition" BROAD [GOC:TermGenie]
synonym: "activation of meiotic cell cycle phase transition" NARROW [GOC:TermGenie]
synonym: "positive regulation of cell cycle transition" BROAD [GOC:TermGenie]
synonym: "up regulation of cell cycle transition" BROAD [GOC:TermGenie]
synonym: "up regulation of meiotic cell cycle phase transition" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell cycle transition" BROAD [GOC:TermGenie]
synonym: "up-regulation of meiotic cell cycle phase transition" EXACT [GOC:TermGenie]
synonym: "upregulation of cell cycle transition" BROAD [GOC:TermGenie]
synonym: "upregulation of meiotic cell cycle phase transition" EXACT [GOC:TermGenie]
is_a: GO:0051446 ! positive regulation of meiotic cell cycle
is_a: GO:1901989 ! positive regulation of cell cycle phase transition
is_a: GO:1901993 ! regulation of meiotic cell cycle phase transition
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044771 ! meiotic cell cycle phase transition
relationship: positively_regulates GO:0044771 ! meiotic cell cycle phase transition
created_by: jl
creation_date: 2013-03-19T16:15:08Z

[Term]
id: GO:1901996
name: regulation of indoleacetic acid biosynthetic process via tryptophan
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of indoleacetic acid biosynthetic process via tryptophan." [GOC:TermGenie, PMID:23377040]
synonym: "regulation of IAA biosynthetic process via tryptophan" EXACT [GOC:TermGenie]
synonym: "regulation of indoleacetic acid anabolism via tryptophan" EXACT [GOC:TermGenie]
synonym: "regulation of indoleacetic acid formation via tryptophan" EXACT [GOC:TermGenie]
synonym: "regulation of indoleacetic acid synthesis via tryptophan" EXACT [GOC:TermGenie]
is_a: GO:0010600 ! regulation of auxin biosynthetic process
is_a: GO:0090357 ! regulation of tryptophan metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009848 ! indoleacetic acid biosynthetic process via tryptophan
relationship: regulates GO:0009848 ! indoleacetic acid biosynthetic process via tryptophan
created_by: tb
creation_date: 2013-03-19T19:14:09Z

[Term]
id: GO:1901997
name: negative regulation of indoleacetic acid biosynthetic process via tryptophan
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of indoleacetic acid biosynthetic process via tryptophan." [GOC:TermGenie, PMID:23377040]
synonym: "down regulation of IAA biosynthetic process via tryptophan" EXACT [GOC:TermGenie]
synonym: "down regulation of indoleacetic acid anabolism via tryptophan" EXACT [GOC:TermGenie]
synonym: "down regulation of indoleacetic acid biosynthetic process via tryptophan" EXACT [GOC:TermGenie]
synonym: "down regulation of indoleacetic acid formation via tryptophan" EXACT [GOC:TermGenie]
synonym: "down regulation of indoleacetic acid synthesis via tryptophan" EXACT [GOC:TermGenie]
synonym: "down-regulation of IAA biosynthetic process via tryptophan" EXACT [GOC:TermGenie]
synonym: "down-regulation of indoleacetic acid anabolism via tryptophan" EXACT [GOC:TermGenie]
synonym: "down-regulation of indoleacetic acid biosynthetic process via tryptophan" EXACT [GOC:TermGenie]
synonym: "down-regulation of indoleacetic acid formation via tryptophan" EXACT [GOC:TermGenie]
synonym: "down-regulation of indoleacetic acid synthesis via tryptophan" EXACT [GOC:TermGenie]
synonym: "downregulation of IAA biosynthetic process via tryptophan" EXACT [GOC:TermGenie]
synonym: "downregulation of indoleacetic acid anabolism via tryptophan" EXACT [GOC:TermGenie]
synonym: "downregulation of indoleacetic acid biosynthetic process via tryptophan" EXACT [GOC:TermGenie]
synonym: "downregulation of indoleacetic acid formation via tryptophan" EXACT [GOC:TermGenie]
synonym: "downregulation of indoleacetic acid synthesis via tryptophan" EXACT [GOC:TermGenie]
synonym: "inhibition of IAA biosynthetic process via tryptophan" EXACT [GOC:TermGenie]
synonym: "inhibition of indoleacetic acid anabolism via tryptophan" EXACT [GOC:TermGenie]
synonym: "inhibition of indoleacetic acid biosynthetic process via tryptophan" NARROW [GOC:TermGenie]
synonym: "inhibition of indoleacetic acid formation via tryptophan" EXACT [GOC:TermGenie]
synonym: "inhibition of indoleacetic acid synthesis via tryptophan" EXACT [GOC:TermGenie]
synonym: "negative regulation of IAA biosynthetic process via tryptophan" EXACT [GOC:TermGenie]
synonym: "negative regulation of indoleacetic acid anabolism via tryptophan" EXACT [GOC:TermGenie]
synonym: "negative regulation of indoleacetic acid formation via tryptophan" EXACT [GOC:TermGenie]
synonym: "negative regulation of indoleacetic acid synthesis via tryptophan" EXACT [GOC:TermGenie]
is_a: GO:0032353 ! negative regulation of hormone biosynthetic process
is_a: GO:0045763 ! negative regulation of cellular amino acid metabolic process
is_a: GO:0090356 ! negative regulation of auxin metabolic process
is_a: GO:1901996 ! regulation of indoleacetic acid biosynthetic process via tryptophan
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009848 ! indoleacetic acid biosynthetic process via tryptophan
relationship: negatively_regulates GO:0009848 ! indoleacetic acid biosynthetic process via tryptophan
created_by: tb
creation_date: 2013-03-19T19:14:13Z

[Term]
id: GO:1901998
name: toxin transport
namespace: biological_process
def: "The directed movement of a toxin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:TermGenie, PMID:17118486]
is_a: GO:0006810 ! transport
created_by: dph
creation_date: 2013-03-19T19:24:55Z

[Term]
id: GO:1901999
name: homogentisate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving homogentisate." [GOC:TermGenie, PMID:22980205]
synonym: "homogentisate metabolism" EXACT [GOC:TermGenie]
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
created_by: tb
creation_date: 2013-03-21T00:01:02Z

[Term]
id: GO:1902000
name: homogentisate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of homogentisate." [GOC:TermGenie, PMID:22980205]
synonym: "homogentisate breakdown" EXACT [GOC:TermGenie]
synonym: "homogentisate catabolism" EXACT [GOC:TermGenie]
synonym: "homogentisate degradation" EXACT [GOC:TermGenie]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:1901999 ! homogentisate metabolic process
created_by: tb
creation_date: 2013-03-21T00:01:12Z

[Term]
id: GO:1902001
name: fatty acid transmembrane transport
namespace: biological_process
def: "The directed movement of fatty acid across a membrane." [GOC:rb, GOC:TermGenie, PMID:9395310]
is_a: GO:0015908 ! fatty acid transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport
created_by: pr
creation_date: 2013-03-21T09:57:00Z

[Term]
id: GO:1902002
name: protein phosphorylation involved in cellular protein catabolic process
namespace: biological_process
def: "Any protein phosphorylation that is involved in cellular protein catabolic process." [GOC:rb, GOC:TermGenie, PMID:21098119, PMID:21993622, PMID:23264631]
synonym: "protein amino acid phosphorylation involved in cellular protein breakdown" EXACT [GOC:TermGenie]
synonym: "protein amino acid phosphorylation involved in cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "protein amino acid phosphorylation involved in cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "protein amino acid phosphorylation involved in cellular protein degradation" EXACT [GOC:TermGenie]
synonym: "protein phosphorylation involved in cellular protein breakdown" EXACT [GOC:TermGenie]
synonym: "protein phosphorylation involved in cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "protein phosphorylation involved in cellular protein degradation" EXACT [GOC:TermGenie]
is_a: GO:0006468 ! protein phosphorylation
intersection_of: GO:0006468 ! protein phosphorylation
intersection_of: part_of GO:0044257 ! cellular protein catabolic process
relationship: part_of GO:0044257 ! cellular protein catabolic process
created_by: pr
creation_date: 2013-03-21T10:08:19Z

[Term]
id: GO:1902003
name: regulation of beta-amyloid formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of beta-amyloid formation." [GOC:dph, GOC:TermGenie, PMID:17098871]
is_a: GO:0034248 ! regulation of cellular amide metabolic process
is_a: GO:1902991 ! regulation of amyloid precursor protein catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034205 ! beta-amyloid formation
relationship: regulates GO:0034205 ! beta-amyloid formation
created_by: dph
creation_date: 2013-03-21T19:59:26Z

[Term]
id: GO:1902004
name: positive regulation of beta-amyloid formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of beta-amyloid formation." [GOC:dph, GOC:TermGenie, PMID:17098871]
synonym: "activation of beta-amyloid formation" NARROW [GOC:TermGenie]
synonym: "up regulation of beta-amyloid formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of beta-amyloid formation" EXACT [GOC:TermGenie]
synonym: "upregulation of beta-amyloid formation" EXACT [GOC:TermGenie]
is_a: GO:0034250 ! positive regulation of cellular amide metabolic process
is_a: GO:1902003 ! regulation of beta-amyloid formation
is_a: GO:1902993 ! positive regulation of amyloid precursor protein catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034205 ! beta-amyloid formation
relationship: positively_regulates GO:0034205 ! beta-amyloid formation
created_by: dph
creation_date: 2013-03-21T19:59:31Z

[Term]
id: GO:1902005
name: regulation of proline biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of proline biosynthetic process." [GOC:TermGenie, PMID:23415322]
synonym: "regulation of proline anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of proline biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of proline formation" EXACT [GOC:TermGenie]
synonym: "regulation of proline synthesis" EXACT [GOC:TermGenie]
is_a: GO:2000214 ! regulation of proline metabolic process
is_a: GO:2000282 ! regulation of cellular amino acid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006561 ! proline biosynthetic process
relationship: regulates GO:0006561 ! proline biosynthetic process
created_by: tb
creation_date: 2013-03-21T21:48:07Z

[Term]
id: GO:1902006
name: negative regulation of proline biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of proline biosynthetic process." [GOC:TermGenie, PMID:23415322]
synonym: "down regulation of proline anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of proline biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of proline biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of proline formation" EXACT [GOC:TermGenie]
synonym: "down regulation of proline synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of proline anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of proline biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of proline biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of proline formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of proline synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of proline anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of proline biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of proline biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of proline formation" EXACT [GOC:TermGenie]
synonym: "downregulation of proline synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of proline anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of proline biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of proline biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of proline formation" EXACT [GOC:TermGenie]
synonym: "inhibition of proline synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of proline anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of proline biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of proline formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of proline synthesis" EXACT [GOC:TermGenie]
is_a: GO:1902005 ! regulation of proline biosynthetic process
is_a: GO:2000215 ! negative regulation of proline metabolic process
is_a: GO:2000283 ! negative regulation of cellular amino acid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006561 ! proline biosynthetic process
relationship: negatively_regulates GO:0006561 ! proline biosynthetic process
created_by: tb
creation_date: 2013-03-21T21:48:12Z

[Term]
id: GO:1902007
name: regulation of toxin transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of toxin transport." [GOC:dph, GOC:TermGenie, PMID:22792315]
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1901998 ! toxin transport
relationship: regulates GO:1901998 ! toxin transport
created_by: dph
creation_date: 2013-03-22T12:53:56Z

[Term]
id: GO:1902008
name: negative regulation of toxin transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of toxin transport." [GOC:dph, GOC:TermGenie, PMID:22792315]
synonym: "down regulation of toxin transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of toxin transport" EXACT [GOC:TermGenie]
synonym: "downregulation of toxin transport" EXACT [GOC:TermGenie]
synonym: "inhibition of toxin transport" NARROW [GOC:TermGenie]
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:1902007 ! regulation of toxin transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1901998 ! toxin transport
relationship: negatively_regulates GO:1901998 ! toxin transport
created_by: dph
creation_date: 2013-03-22T12:54:00Z

[Term]
id: GO:1902009
name: positive regulation of toxin transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of toxin transport." [GOC:dph, GOC:TermGenie, PMID:22792315]
synonym: "activation of toxin transport" NARROW [GOC:TermGenie]
synonym: "up regulation of toxin transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of toxin transport" EXACT [GOC:TermGenie]
synonym: "upregulation of toxin transport" EXACT [GOC:TermGenie]
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:1902007 ! regulation of toxin transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1901998 ! toxin transport
relationship: positively_regulates GO:1901998 ! toxin transport
created_by: dph
creation_date: 2013-03-22T12:54:09Z

[Term]
id: GO:1902010
name: negative regulation of translation in response to endoplasmic reticulum stress
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of translation as a result of endoplasmic reticulum stress." [GOC:dph, GOC:TermGenie, PMID:10882126]
synonym: "down regulation of protein biosynthetic process involved in ER stress response" EXACT [GOC:TermGenie]
synonym: "down regulation of protein biosynthetic process involved in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "down regulation of protein biosynthetic process involved in response to ER stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein biosynthetic process involved in ER stress response" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein biosynthetic process involved in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein biosynthetic process involved in response to ER stress" EXACT [GOC:TermGenie]
synonym: "downregulation of protein biosynthetic process involved in ER stress response" EXACT [GOC:TermGenie]
synonym: "downregulation of protein biosynthetic process involved in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "downregulation of protein biosynthetic process involved in response to ER stress" EXACT [GOC:TermGenie]
synonym: "inhibition of protein biosynthetic process involved in ER stress response" NARROW [GOC:TermGenie]
synonym: "inhibition of protein biosynthetic process involved in response to endoplasmic reticulum stress" NARROW [GOC:TermGenie]
synonym: "inhibition of protein biosynthetic process involved in response to ER stress" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein anabolism involved in ER stress response" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein anabolism involved in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein anabolism involved in response to ER stress" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein biosynthesis involved in ER stress response" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein biosynthesis involved in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein biosynthesis involved in response to ER stress" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein biosynthetic process involved in ER stress response" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein biosynthetic process involved in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein biosynthetic process involved in response to ER stress" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein formation involved in ER stress response" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein formation involved in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein formation involved in response to ER stress" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein synthesis involved in ER stress response" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein synthesis involved in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein synthesis involved in response to ER stress" EXACT [GOC:TermGenie]
synonym: "negative regulation of translation involved in ER stress response" EXACT [GOC:TermGenie]
synonym: "negative regulation of translation involved in response to ER stress" EXACT [GOC:TermGenie]
synonym: "protein biosynthesis inhibitor activity involved in ER stress response" RELATED [GOC:TermGenie]
synonym: "protein biosynthesis inhibitor activity involved in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "protein biosynthesis inhibitor activity involved in response to ER stress" RELATED [GOC:TermGenie]
synonym: "protein biosynthetic process inhibitor activity involved in ER stress response" RELATED [GOC:TermGenie]
synonym: "protein biosynthetic process inhibitor activity involved in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "protein biosynthetic process inhibitor activity involved in response to ER stress" RELATED [GOC:TermGenie]
is_a: GO:0032055 ! negative regulation of translation in response to stress
is_a: GO:0036490 ! regulation of translation in response to endoplasmic reticulum stress
created_by: dph
creation_date: 2013-03-22T13:43:26Z

[Term]
id: GO:1902011
name: poly(ribitol phosphate) teichoic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving poly(ribitol phosphate) teichoic acid." [GOC:TermGenie, PMID:11882717, UniPathway:UPA00790]
synonym: "poly(ribitol phosphate) teichoic acid metabolism" EXACT [GOC:TermGenie]
is_a: GO:0046374 ! teichoic acid metabolic process
created_by: tb
creation_date: 2013-03-22T15:43:36Z

[Term]
id: GO:1902012
name: poly(ribitol phosphate) teichoic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of poly(ribitol phosphate) teichoic acid." [GOC:TermGenie, PMID:11882717, UniPathway:UPA00790]
synonym: "poly(ribitol phosphate) teichoic acid anabolism" EXACT [GOC:TermGenie]
synonym: "poly(ribitol phosphate) teichoic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "poly(ribitol phosphate) teichoic acid formation" EXACT [GOC:TermGenie]
synonym: "poly(ribitol phosphate) teichoic acid synthesis" EXACT [GOC:TermGenie]
is_a: GO:0019350 ! teichoic acid biosynthetic process
is_a: GO:1902011 ! poly(ribitol phosphate) teichoic acid metabolic process
created_by: tb
creation_date: 2013-03-22T15:43:40Z

[Term]
id: GO:1902013
name: poly(glycerol phosphate) teichoic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving poly(glycerol phosphate) teichoic acid." [GOC:TermGenie, PMID:11882717, UniPathway:UPA00827]
synonym: "poly(glycerol phosphate) teichoic acid metabolism" EXACT [GOC:TermGenie]
is_a: GO:0046374 ! teichoic acid metabolic process
created_by: tb
creation_date: 2013-03-22T15:43:45Z

[Term]
id: GO:1902014
name: poly(glycerol phosphate) teichoic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of poly(glycerol phosphate) teichoic acid." [GOC:TermGenie, PMID:11882717, UniPathway:UPA00827]
synonym: "poly(glycerol phosphate) teichoic acid anabolism" EXACT [GOC:TermGenie]
synonym: "poly(glycerol phosphate) teichoic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "poly(glycerol phosphate) teichoic acid formation" EXACT [GOC:TermGenie]
synonym: "poly(glycerol phosphate) teichoic acid synthesis" EXACT [GOC:TermGenie]
is_a: GO:0019350 ! teichoic acid biosynthetic process
is_a: GO:1902013 ! poly(glycerol phosphate) teichoic acid metabolic process
created_by: tb
creation_date: 2013-03-22T15:43:50Z

[Term]
id: GO:1902015
name: poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid." [GOC:TermGenie, PMID:16735734, UniPathway:UPA00789, UniPathway:UPA00828]
synonym: "poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid metabolism" EXACT [GOC:TermGenie]
synonym: "poly(glucosyl N-acetylgalactosamine 1-phosphate) teichoic acid metabolic process" EXACT []
synonym: "poly(glucosyl N-acetylgalactosamine 1-phosphate) teichoic acid metabolism" EXACT []
is_a: GO:0046374 ! teichoic acid metabolic process
created_by: tb
creation_date: 2013-03-22T15:43:55Z

[Term]
id: GO:1902016
name: poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid." [GOC:TermGenie, PMID:16735734, UniPathway:UPA00789, UniPathway:UPA00828]
synonym: "poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid anabolism" EXACT [GOC:TermGenie]
synonym: "poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid formation" EXACT [GOC:TermGenie]
synonym: "poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid synthesis" EXACT [GOC:TermGenie]
synonym: "poly(glucosyl N-acetylgalactosamine 1-phosphate) teichoic acid biosynthesis" EXACT []
synonym: "poly(glucosyl N-acetylgalactosamine 1-phosphate) teichoic acid biosynthetic process" EXACT []
is_a: GO:0019350 ! teichoic acid biosynthetic process
is_a: GO:1902015 ! poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid metabolic process
created_by: tb
creation_date: 2013-03-22T15:43:59Z

[Term]
id: GO:1902017
name: regulation of cilium assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cilium assembly." [GOC:dph, GOC:TermGenie, PMID:17719545]
synonym: "regulation of ciliogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of cilium biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0022604 ! regulation of cell morphogenesis
is_a: GO:0060491 ! regulation of cell projection assembly
is_a: GO:1902115 ! regulation of organelle assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042384 ! cilium assembly
relationship: regulates GO:0042384 ! cilium assembly
created_by: dph
creation_date: 2013-03-26T18:10:51Z

[Term]
id: GO:1902018
name: negative regulation of cilium assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cilium assembly." [GOC:dph, GOC:TermGenie, PMID:17719545]
synonym: "down regulation of ciliogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of cilium assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of cilium biogenesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of ciliogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of cilium assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of cilium biogenesis" RELATED [GOC:TermGenie]
synonym: "downregulation of ciliogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of cilium assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of cilium biogenesis" RELATED [GOC:TermGenie]
synonym: "inhibition of ciliogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of cilium assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of cilium biogenesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of ciliogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of cilium biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0031345 ! negative regulation of cell projection organization
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:1902017 ! regulation of cilium assembly
is_a: GO:1902116 ! negative regulation of organelle assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042384 ! cilium assembly
relationship: negatively_regulates GO:0042384 ! cilium assembly
created_by: dph
creation_date: 2013-03-26T18:10:56Z

[Term]
id: GO:1902019
name: regulation of cilium-dependent cell motility
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cilium-dependent cell motility." [GOC:cilia, GOC:jl, GOC:TermGenie]
synonym: "regulation of ciliary cell motility" RELATED []
synonym: "regulation of cilium cell motility" EXACT []
is_a: GO:0003352 ! regulation of cilium movement
is_a: GO:2000145 ! regulation of cell motility
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060285 ! cilium-dependent cell motility
relationship: regulates GO:0060285 ! cilium-dependent cell motility
created_by: jl
creation_date: 2013-03-27T14:42:38Z

[Term]
id: GO:1902020
name: negative regulation of cilium-dependent cell motility
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cilium-dependent cell motility." [GOC:cilia, GOC:jl, GOC:TermGenie]
synonym: "down regulation of ciliary cell motility" EXACT [GOC:TermGenie]
synonym: "down-regulation of ciliary cell motility" EXACT [GOC:TermGenie]
synonym: "downregulation of ciliary cell motility" EXACT [GOC:TermGenie]
synonym: "inhibition of ciliary cell motility" NARROW [GOC:TermGenie]
synonym: "negative regulation of ciliary cell motility" RELATED []
synonym: "negative regulation of cilium cell motility" EXACT []
is_a: GO:1902019 ! regulation of cilium-dependent cell motility
is_a: GO:2000146 ! negative regulation of cell motility
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060285 ! cilium-dependent cell motility
relationship: negatively_regulates GO:0060285 ! cilium-dependent cell motility
created_by: jl
creation_date: 2013-03-27T14:42:42Z

[Term]
id: GO:1902021
name: regulation of bacterial-type flagellum-dependent cell motility
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of bacterial-type flagellum-dependent cell motility." [GOC:cilia, GOC:jl, GOC:TermGenie]
synonym: "regulation of bacterial-type flagellar cell motility" RELATED []
synonym: "regulation of bacterial-type flagellum cell motility" EXACT []
synonym: "regulation of flagellin-based flagellar cell motility" EXACT [GOC:TermGenie]
is_a: GO:2000145 ! regulation of cell motility
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071973 ! bacterial-type flagellum-dependent cell motility
relationship: regulates GO:0071973 ! bacterial-type flagellum-dependent cell motility
created_by: jl
creation_date: 2013-03-27T14:42:50Z

[Term]
id: GO:1902022
name: L-lysine transport
namespace: biological_process
def: "The directed movement of a L-lysine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:kmv, GOC:TermGenie, PMID:22822152]
is_a: GO:0015807 ! L-amino acid transport
is_a: GO:0015819 ! lysine transport
created_by: kmv
creation_date: 2013-03-27T16:09:06Z

[Term]
id: GO:1902023
name: L-arginine transport
namespace: biological_process
def: "The directed movement of a L-arginine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:kmv, GOC:TermGenie, PMID:22822152]
is_a: GO:0015807 ! L-amino acid transport
is_a: GO:0015809 ! arginine transport
created_by: kmv
creation_date: 2013-03-27T16:09:11Z

[Term]
id: GO:1902024
name: L-histidine transport
namespace: biological_process
def: "The directed movement of a L-histidine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:kmv, GOC:TermGenie, PMID:22822152]
is_a: GO:0015807 ! L-amino acid transport
is_a: GO:0015817 ! histidine transport
created_by: kmv
creation_date: 2013-03-27T16:09:15Z

[Term]
id: GO:1902025
name: nitrate import
namespace: biological_process
def: "The directed movement of nitrate into a cell or organelle." [GOC:TermGenie, PMID:22658680]
synonym: "nitrate influx" EXACT []
synonym: "nitrate uptake" EXACT []
is_a: GO:0015706 ! nitrate transport
created_by: tb
creation_date: 2013-03-27T21:32:58Z

[Term]
id: GO:1902026
name: regulation of cartilage condensation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cartilage condensation." [GOC:TermGenie, PMID:17202865]
is_a: GO:0022407 ! regulation of cell-cell adhesion
is_a: GO:0061035 ! regulation of cartilage development
is_a: GO:2000027 ! regulation of organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001502 ! cartilage condensation
relationship: regulates GO:0001502 ! cartilage condensation
created_by: jl
creation_date: 2013-03-28T17:02:42Z

[Term]
id: GO:1902027
name: positive regulation of cartilage condensation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cartilage condensation." [GOC:TermGenie, PMID:17202865]
synonym: "activation of cartilage condensation" NARROW [GOC:TermGenie]
synonym: "up regulation of cartilage condensation" EXACT [GOC:TermGenie]
synonym: "up-regulation of cartilage condensation" EXACT [GOC:TermGenie]
synonym: "upregulation of cartilage condensation" EXACT [GOC:TermGenie]
is_a: GO:0022409 ! positive regulation of cell-cell adhesion
is_a: GO:0061036 ! positive regulation of cartilage development
is_a: GO:1902026 ! regulation of cartilage condensation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001502 ! cartilage condensation
relationship: positively_regulates GO:0001502 ! cartilage condensation
created_by: jl
creation_date: 2013-03-28T17:02:46Z

[Term]
id: GO:1902028
name: regulation of histone H3-K18 acetylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of histone H3-K18 acetylation." [GOC:TermGenie, PMID:22110608]
synonym: "regulation of histone H3 acetylation at K18" EXACT [GOC:TermGenie]
synonym: "regulation of histone H3K18 acetylation" EXACT [GOC:TermGenie]
is_a: GO:0035065 ! regulation of histone acetylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043971 ! histone H3-K18 acetylation
relationship: regulates GO:0043971 ! histone H3-K18 acetylation
created_by: jl
creation_date: 2013-03-28T20:17:39Z

[Term]
id: GO:1902029
name: positive regulation of histone H3-K18 acetylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of histone H3-K18 acetylation." [GOC:TermGenie, PMID:22110608]
synonym: "activation of histone H3 acetylation at K18" EXACT [GOC:TermGenie]
synonym: "activation of histone H3-K18 acetylation" NARROW [GOC:TermGenie]
synonym: "activation of histone H3K18 acetylation" EXACT [GOC:TermGenie]
synonym: "positive regulation of histone H3 acetylation at K18" EXACT [GOC:TermGenie]
synonym: "positive regulation of histone H3K18 acetylation" EXACT [GOC:TermGenie]
synonym: "up regulation of histone H3 acetylation at K18" EXACT [GOC:TermGenie]
synonym: "up regulation of histone H3-K18 acetylation" EXACT [GOC:TermGenie]
synonym: "up regulation of histone H3K18 acetylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of histone H3 acetylation at K18" EXACT [GOC:TermGenie]
synonym: "up-regulation of histone H3-K18 acetylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of histone H3K18 acetylation" EXACT [GOC:TermGenie]
synonym: "upregulation of histone H3 acetylation at K18" EXACT [GOC:TermGenie]
synonym: "upregulation of histone H3-K18 acetylation" EXACT [GOC:TermGenie]
synonym: "upregulation of histone H3K18 acetylation" EXACT [GOC:TermGenie]
is_a: GO:0035066 ! positive regulation of histone acetylation
is_a: GO:1902028 ! regulation of histone H3-K18 acetylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043971 ! histone H3-K18 acetylation
relationship: positively_regulates GO:0043971 ! histone H3-K18 acetylation
created_by: jl
creation_date: 2013-03-28T20:17:44Z

[Term]
id: GO:1902030
name: negative regulation of histone H3-K18 acetylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K18 acetylation." [GOC:TermGenie, PMID:22110608]
synonym: "down regulation of histone H3 acetylation at K18" EXACT [GOC:TermGenie]
synonym: "down regulation of histone H3-K18 acetylation" EXACT [GOC:TermGenie]
synonym: "down regulation of histone H3K18 acetylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of histone H3 acetylation at K18" EXACT [GOC:TermGenie]
synonym: "down-regulation of histone H3-K18 acetylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of histone H3K18 acetylation" EXACT [GOC:TermGenie]
synonym: "downregulation of histone H3 acetylation at K18" EXACT [GOC:TermGenie]
synonym: "downregulation of histone H3-K18 acetylation" EXACT [GOC:TermGenie]
synonym: "downregulation of histone H3K18 acetylation" EXACT [GOC:TermGenie]
synonym: "inhibition of histone H3 acetylation at K18" EXACT [GOC:TermGenie]
synonym: "inhibition of histone H3-K18 acetylation" NARROW [GOC:TermGenie]
synonym: "inhibition of histone H3K18 acetylation" EXACT [GOC:TermGenie]
synonym: "negative regulation of histone H3 acetylation at K18" EXACT [GOC:TermGenie]
synonym: "negative regulation of histone H3K18 acetylation" EXACT [GOC:TermGenie]
is_a: GO:0035067 ! negative regulation of histone acetylation
is_a: GO:1902028 ! regulation of histone H3-K18 acetylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043971 ! histone H3-K18 acetylation
relationship: negatively_regulates GO:0043971 ! histone H3-K18 acetylation
created_by: jl
creation_date: 2013-03-28T20:19:39Z

[Term]
id: GO:1902031
name: regulation of NADP metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of NADP metabolic process." [GOC:TermGenie, PMID:23334421]
synonym: "regulation of NAD phosphorylation and dephosphorylation" RELATED [GOC:TermGenie]
synonym: "regulation of NADP (oxidized) metabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of NADP (oxidized) metabolism" EXACT [GOC:TermGenie]
synonym: "regulation of NADP (reduced) metabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of NADP (reduced) metabolism" EXACT [GOC:TermGenie]
synonym: "regulation of NADP metabolism" EXACT [GOC:TermGenie]
synonym: "regulation of NADPH metabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of NADPH metabolism" EXACT [GOC:TermGenie]
synonym: "regulation of nicotinamide adenine dinucleotide phosphate metabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of nicotinamide adenine dinucleotide phosphate metabolism" EXACT [GOC:TermGenie]
synonym: "regulation of oxidized NADP metabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of oxidized NADP metabolism" EXACT [GOC:TermGenie]
synonym: "regulation of oxidized nicotinamide adenine dinucleotide phosphate metabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of oxidized nicotinamide adenine dinucleotide phosphate metabolism" EXACT [GOC:TermGenie]
synonym: "regulation of reduced NADP metabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of reduced NADP metabolism" EXACT [GOC:TermGenie]
synonym: "regulation of reduced nicotinamide adenine dinucleotide phosphate metabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of reduced nicotinamide adenine dinucleotide phosphate metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006140 ! regulation of nucleotide metabolic process
is_a: GO:0051196 ! regulation of coenzyme metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006739 ! NADP metabolic process
relationship: regulates GO:0006739 ! NADP metabolic process
created_by: jl
creation_date: 2013-03-28T20:21:48Z

[Term]
id: GO:1902032
name: obsolete regulation of transcription from RNA polymerase II promoter involved in response to osmotic stress
namespace: biological_process
def: "OBSOLETE. Any regulation of transcription from RNA polymerase II promoter that is involved in response to osmotic stress." [GOC:kmv, GOC:TermGenie, PMID:18636113]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "global transcription regulation from Pol II promoter involved in osmotic response" RELATED [GOC:TermGenie]
synonym: "global transcription regulation from Pol II promoter involved in osmotic stress response" RELATED [GOC:TermGenie]
synonym: "global transcription regulation from Pol II promoter involved in response to osmotic stress" RELATED [GOC:TermGenie]
synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in osmotic response" RELATED [GOC:TermGenie]
synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in osmotic stress response" RELATED [GOC:TermGenie]
synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in response to osmotic stress" RELATED [GOC:TermGenie]
synonym: "regulation of global transcription from Pol II promoter involved in osmotic response" RELATED [GOC:TermGenie]
synonym: "regulation of global transcription from Pol II promoter involved in osmotic stress response" RELATED [GOC:TermGenie]
synonym: "regulation of global transcription from Pol II promoter involved in response to osmotic stress" RELATED [GOC:TermGenie]
synonym: "regulation of transcription from Pol II promoter involved in osmotic response" EXACT [GOC:TermGenie]
synonym: "regulation of transcription from Pol II promoter involved in osmotic stress response" EXACT [GOC:TermGenie]
synonym: "regulation of transcription from Pol II promoter involved in response to osmotic stress" EXACT [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter involved in osmotic response" EXACT [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter involved in osmotic stress response" EXACT [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter involved in response to osmotic stress" EXACT []
synonym: "regulation of transcription from RNA polymerase II promoter, global involved in osmotic response" RELATED [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter, global involved in osmotic stress response" RELATED [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter, global involved in response to osmotic stress" RELATED [GOC:TermGenie]
is_obsolete: true
created_by: kmv
creation_date: 2013-04-01T17:24:04Z

[Term]
id: GO:1902033
name: regulation of hematopoietic stem cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hematopoietic stem cell proliferation." [GOC:TermGenie, PMID:23403623]
synonym: "regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0072091 ! regulation of stem cell proliferation
is_a: GO:1903706 ! regulation of hemopoiesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071425 ! hematopoietic stem cell proliferation
relationship: regulates GO:0071425 ! hematopoietic stem cell proliferation
created_by: ss
creation_date: 2013-04-02T05:13:19Z

[Term]
id: GO:1902034
name: negative regulation of hematopoietic stem cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell proliferation." [GOC:TermGenie, PMID:23403623]
synonym: "down regulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "down regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "inhibition of hematopoietic stem cell proliferation" NARROW [GOC:TermGenie]
synonym: "inhibition of hemopoietic stem cell proliferation" NARROW [GOC:TermGenie]
synonym: "negative regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:1902033 ! regulation of hematopoietic stem cell proliferation
is_a: GO:1903707 ! negative regulation of hemopoiesis
is_a: GO:2000647 ! negative regulation of stem cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071425 ! hematopoietic stem cell proliferation
relationship: negatively_regulates GO:0071425 ! hematopoietic stem cell proliferation
created_by: ss
creation_date: 2013-04-02T05:13:24Z

[Term]
id: GO:1902035
name: positive regulation of hematopoietic stem cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell proliferation." [GOC:TermGenie, PMID:23403623]
synonym: "activation of hematopoietic stem cell proliferation" NARROW [GOC:TermGenie]
synonym: "activation of hemopoietic stem cell proliferation" NARROW [GOC:TermGenie]
synonym: "positive regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:1902033 ! regulation of hematopoietic stem cell proliferation
is_a: GO:1903708 ! positive regulation of hemopoiesis
is_a: GO:2000648 ! positive regulation of stem cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071425 ! hematopoietic stem cell proliferation
relationship: positively_regulates GO:0071425 ! hematopoietic stem cell proliferation
created_by: ss
creation_date: 2013-04-02T05:13:31Z

[Term]
id: GO:1902036
name: regulation of hematopoietic stem cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hematopoietic stem cell differentiation." [GOC:TermGenie, PMID:23403623]
synonym: "regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:1901532 ! regulation of hematopoietic progenitor cell differentiation
is_a: GO:2000736 ! regulation of stem cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060218 ! hematopoietic stem cell differentiation
relationship: regulates GO:0060218 ! hematopoietic stem cell differentiation
created_by: ss
creation_date: 2013-04-02T05:19:09Z

[Term]
id: GO:1902037
name: negative regulation of hematopoietic stem cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell differentiation." [GOC:TermGenie, PMID:23403623]
synonym: "down regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of haematopoietic stem cell differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of haemopoietic stem cell differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of hematopoietic stem cell differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of hemopoietic stem cell differentiation" NARROW [GOC:TermGenie]
synonym: "negative regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "negative regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "negative regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:1901533 ! negative regulation of hematopoietic progenitor cell differentiation
is_a: GO:1902036 ! regulation of hematopoietic stem cell differentiation
is_a: GO:2000737 ! negative regulation of stem cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060218 ! hematopoietic stem cell differentiation
relationship: negatively_regulates GO:0060218 ! hematopoietic stem cell differentiation
created_by: ss
creation_date: 2013-04-02T05:19:14Z

[Term]
id: GO:1902038
name: positive regulation of hematopoietic stem cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell differentiation." [GOC:TermGenie, PMID:23403623]
synonym: "activation of haematopoietic stem cell differentiation" NARROW [GOC:TermGenie]
synonym: "activation of haemopoietic stem cell differentiation" NARROW [GOC:TermGenie]
synonym: "activation of hematopoietic stem cell differentiation" NARROW [GOC:TermGenie]
synonym: "activation of hemopoietic stem cell differentiation" NARROW [GOC:TermGenie]
synonym: "positive regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:1901534 ! positive regulation of hematopoietic progenitor cell differentiation
is_a: GO:1902036 ! regulation of hematopoietic stem cell differentiation
is_a: GO:2000738 ! positive regulation of stem cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060218 ! hematopoietic stem cell differentiation
relationship: positively_regulates GO:0060218 ! hematopoietic stem cell differentiation
created_by: ss
creation_date: 2013-04-02T05:19:19Z

[Term]
id: GO:1902039
name: negative regulation of seed dormancy process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of seed dormancy process." [GOC:TermGenie, PMID:23378449]
synonym: "down regulation of seed dormancy" RELATED [GOC:TermGenie]
synonym: "down regulation of seed dormancy process" EXACT [GOC:TermGenie]
synonym: "down-regulation of seed dormancy" RELATED [GOC:TermGenie]
synonym: "down-regulation of seed dormancy process" EXACT [GOC:TermGenie]
synonym: "downregulation of seed dormancy" RELATED [GOC:TermGenie]
synonym: "downregulation of seed dormancy process" EXACT [GOC:TermGenie]
synonym: "inhibition of seed dormancy" RELATED [GOC:TermGenie]
synonym: "inhibition of seed dormancy process" NARROW [GOC:TermGenie]
synonym: "negative regulation of seed dormancy" RELATED [GOC:TermGenie]
is_a: GO:2000033 ! regulation of seed dormancy process
is_a: GO:2000692 ! negative regulation of seed maturation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010162 ! seed dormancy process
relationship: negatively_regulates GO:0010162 ! seed dormancy process
created_by: tb
creation_date: 2013-04-02T22:13:15Z

[Term]
id: GO:1902040
name: positive regulation of seed dormancy process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of seed dormancy process." [GOC:TermGenie, PMID:23378449]
synonym: "activation of seed dormancy" RELATED [GOC:TermGenie]
synonym: "activation of seed dormancy process" NARROW [GOC:TermGenie]
synonym: "positive regulation of seed dormancy" RELATED [GOC:TermGenie]
synonym: "up regulation of seed dormancy" RELATED [GOC:TermGenie]
synonym: "up regulation of seed dormancy process" EXACT [GOC:TermGenie]
synonym: "up-regulation of seed dormancy" RELATED [GOC:TermGenie]
synonym: "up-regulation of seed dormancy process" EXACT [GOC:TermGenie]
synonym: "upregulation of seed dormancy" RELATED [GOC:TermGenie]
synonym: "upregulation of seed dormancy process" EXACT [GOC:TermGenie]
is_a: GO:2000033 ! regulation of seed dormancy process
is_a: GO:2000693 ! positive regulation of seed maturation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010162 ! seed dormancy process
relationship: positively_regulates GO:0010162 ! seed dormancy process
created_by: tb
creation_date: 2013-04-02T22:13:20Z

[Term]
id: GO:1902041
name: regulation of extrinsic apoptotic signaling pathway via death domain receptors
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors." [GOC:TermGenie, PMID:17245429]
synonym: "regulation of death receptor-mediated apoptosis" NARROW [GOC:TermGenie]
is_a: GO:2001236 ! regulation of extrinsic apoptotic signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008625 ! extrinsic apoptotic signaling pathway via death domain receptors
relationship: regulates GO:0008625 ! extrinsic apoptotic signaling pathway via death domain receptors
created_by: lb
creation_date: 2013-04-03T07:16:59Z

[Term]
id: GO:1902042
name: negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors." [GOC:TermGenie, PMID:17245429]
synonym: "down regulation of death receptor-mediated apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of extrinsic apoptotic signaling pathway via death domain receptors" EXACT [GOC:TermGenie]
synonym: "down-regulation of death receptor-mediated apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of extrinsic apoptotic signaling pathway via death domain receptors" EXACT [GOC:TermGenie]
synonym: "downregulation of death receptor-mediated apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of extrinsic apoptotic signaling pathway via death domain receptors" EXACT [GOC:TermGenie]
synonym: "inhibition of death receptor-mediated apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of extrinsic apoptotic signaling pathway via death domain receptors" NARROW [GOC:TermGenie]
synonym: "negative regulation of death receptor-mediated apoptosis" NARROW [GOC:TermGenie]
is_a: GO:1902041 ! regulation of extrinsic apoptotic signaling pathway via death domain receptors
is_a: GO:2001237 ! negative regulation of extrinsic apoptotic signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008625 ! extrinsic apoptotic signaling pathway via death domain receptors
relationship: negatively_regulates GO:0008625 ! extrinsic apoptotic signaling pathway via death domain receptors
created_by: lb
creation_date: 2013-04-03T07:17:04Z

[Term]
id: GO:1902043
name: positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors." [GOC:TermGenie, PMID:17245429]
synonym: "activation of death receptor-mediated apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of extrinsic apoptotic signaling pathway via death domain receptors" NARROW [GOC:TermGenie]
synonym: "positive regulation of death receptor-mediated apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of death receptor-mediated apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of extrinsic apoptotic signaling pathway via death domain receptors" EXACT [GOC:TermGenie]
synonym: "up-regulation of death receptor-mediated apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of extrinsic apoptotic signaling pathway via death domain receptors" EXACT [GOC:TermGenie]
synonym: "upregulation of death receptor-mediated apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of extrinsic apoptotic signaling pathway via death domain receptors" EXACT [GOC:TermGenie]
is_a: GO:1902041 ! regulation of extrinsic apoptotic signaling pathway via death domain receptors
is_a: GO:2001238 ! positive regulation of extrinsic apoptotic signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008625 ! extrinsic apoptotic signaling pathway via death domain receptors
relationship: positively_regulates GO:0008625 ! extrinsic apoptotic signaling pathway via death domain receptors
created_by: lb
creation_date: 2013-04-03T07:17:11Z

[Term]
id: GO:1902044
name: regulation of Fas signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Fas signaling pathway." [GOC:TermGenie, PMID:17245429]
synonym: "regulation of Apo-1 signaling pathway" EXACT [GOC:TermGenie]
synonym: "regulation of CD95 signaling pathway" EXACT [GOC:TermGenie]
synonym: "regulation of FAS ligand-Fas signaling pathway" NARROW [GOC:TermGenie]
synonym: "regulation of Fas receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "regulation of Fas-FasL signaling pathway" NARROW [GOC:TermGenie]
synonym: "regulation of FasL signaling pathway" RELATED [GOC:TermGenie]
synonym: "regulation of FasR signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0009966 ! regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0036337 ! Fas signaling pathway
relationship: regulates GO:0036337 ! Fas signaling pathway
created_by: lb
creation_date: 2013-04-03T07:21:23Z

[Term]
id: GO:1902045
name: negative regulation of Fas signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of Fas signaling pathway." [GOC:TermGenie, PMID:17245429]
synonym: "down regulation of Apo-1 signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of CD95 signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of FAS ligand-Fas signaling pathway" NARROW [GOC:TermGenie]
synonym: "down regulation of Fas receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of Fas signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of Fas-FasL signaling pathway" NARROW [GOC:TermGenie]
synonym: "down regulation of FasL signaling pathway" RELATED [GOC:TermGenie]
synonym: "down regulation of FasR signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of Apo-1 signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of CD95 signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of FAS ligand-Fas signaling pathway" NARROW [GOC:TermGenie]
synonym: "down-regulation of Fas receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of Fas signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of Fas-FasL signaling pathway" NARROW [GOC:TermGenie]
synonym: "down-regulation of FasL signaling pathway" RELATED [GOC:TermGenie]
synonym: "down-regulation of FasR signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of Apo-1 signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of CD95 signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of FAS ligand-Fas signaling pathway" NARROW [GOC:TermGenie]
synonym: "downregulation of Fas receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of Fas signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of Fas-FasL signaling pathway" NARROW [GOC:TermGenie]
synonym: "downregulation of FasL signaling pathway" RELATED [GOC:TermGenie]
synonym: "downregulation of FasR signaling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of Apo-1 signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of CD95 signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of FAS ligand-Fas signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of Fas receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of Fas signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of Fas-FasL signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of FasL signaling pathway" RELATED [GOC:TermGenie]
synonym: "inhibition of FasR signaling pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of Apo-1 signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of CD95 signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of FAS ligand-Fas signaling pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of Fas receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of Fas-FasL signaling pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of FasL signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of FasR signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:1902044 ! regulation of Fas signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0036337 ! Fas signaling pathway
relationship: negatively_regulates GO:0036337 ! Fas signaling pathway
created_by: lb
creation_date: 2013-04-03T07:21:28Z

[Term]
id: GO:1902046
name: positive regulation of Fas signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of Fas signaling pathway." [GOC:TermGenie, PMID:17245429]
synonym: "activation of Apo-1 signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of CD95 signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of FAS ligand-Fas signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of Fas receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of Fas signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of Fas-FasL signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of FasL signaling pathway" RELATED [GOC:TermGenie]
synonym: "activation of FasR signaling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of Apo-1 signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of CD95 signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of FAS ligand-Fas signaling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of Fas receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of Fas-FasL signaling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of FasL signaling pathway" RELATED [GOC:TermGenie]
synonym: "positive regulation of FasR signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of Apo-1 signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of CD95 signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of FAS ligand-Fas signaling pathway" NARROW [GOC:TermGenie]
synonym: "up regulation of Fas receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of Fas signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of Fas-FasL signaling pathway" NARROW [GOC:TermGenie]
synonym: "up regulation of FasL signaling pathway" RELATED [GOC:TermGenie]
synonym: "up regulation of FasR signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of Apo-1 signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of CD95 signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of FAS ligand-Fas signaling pathway" NARROW [GOC:TermGenie]
synonym: "up-regulation of Fas receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of Fas signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of Fas-FasL signaling pathway" NARROW [GOC:TermGenie]
synonym: "up-regulation of FasL signaling pathway" RELATED [GOC:TermGenie]
synonym: "up-regulation of FasR signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of Apo-1 signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of CD95 signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of FAS ligand-Fas signaling pathway" NARROW [GOC:TermGenie]
synonym: "upregulation of Fas receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of Fas signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of Fas-FasL signaling pathway" NARROW [GOC:TermGenie]
synonym: "upregulation of FasL signaling pathway" RELATED [GOC:TermGenie]
synonym: "upregulation of FasR signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:1902044 ! regulation of Fas signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0036337 ! Fas signaling pathway
relationship: positively_regulates GO:0036337 ! Fas signaling pathway
created_by: lb
creation_date: 2013-04-03T07:21:33Z

[Term]
id: GO:1902047
name: polyamine transmembrane transport
namespace: biological_process
def: "The directed movement of a polyamine macromolecule across a membrane." [GOC:TermGenie, GOC:vw]
is_a: GO:0015846 ! polyamine transport
is_a: GO:0055085 ! transmembrane transport
created_by: tb
creation_date: 2013-04-03T15:34:57Z

[Term]
id: GO:1902048
name: neosartoricin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving neosartoricin." [GOC:di, GOC:TermGenie, PMID:23368997]
synonym: "neosartoricin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0030638 ! polyketide metabolic process
is_a: GO:0042180 ! cellular ketone metabolic process
is_a: GO:1900619 ! acetate ester metabolic process
is_a: GO:1902644 ! tertiary alcohol metabolic process
created_by: di
creation_date: 2013-04-08T20:31:02Z

[Term]
id: GO:1902049
name: neosartoricin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of neosartoricin." [GOC:di, GOC:TermGenie, PMID:23368997]
synonym: "neosartoricin breakdown" EXACT [GOC:TermGenie]
synonym: "neosartoricin catabolism" EXACT [GOC:TermGenie]
synonym: "neosartoricin degradation" EXACT [GOC:TermGenie]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0030640 ! polyketide catabolic process
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:0046164 ! alcohol catabolic process
is_a: GO:1902048 ! neosartoricin metabolic process
created_by: di
creation_date: 2013-04-08T20:31:06Z

[Term]
id: GO:1902050
name: neosartoricin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of neosartoricin." [GOC:di, GOC:TermGenie, PMID:23368997]
synonym: "neosartoricin anabolism" EXACT [GOC:TermGenie]
synonym: "neosartoricin biosynthesis" EXACT [GOC:TermGenie]
synonym: "neosartoricin formation" EXACT [GOC:TermGenie]
synonym: "neosartoricin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0030639 ! polyketide biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:1900620 ! acetate ester biosynthetic process
is_a: GO:1902048 ! neosartoricin metabolic process
is_a: GO:1902645 ! tertiary alcohol biosynthetic process
created_by: di
creation_date: 2013-04-08T20:31:11Z

[Term]
id: GO:1902051
name: (25S)-Delta(4)-dafachronate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with (25S)-Delta(4)-dafachronate." [GOC:TermGenie, PMID:16529801]
is_a: GO:0033293 ! monocarboxylic acid binding
is_a: GO:1990239 ! steroid hormone binding
created_by: ab
creation_date: 2013-04-11T08:33:41Z

[Term]
id: GO:1902052
name: (25S)-Delta(7)-dafachronate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with (25S)-Delta(7)-dafachronate." [GOC:TermGenie, PMID:16529801]
is_a: GO:0033293 ! monocarboxylic acid binding
is_a: GO:1990239 ! steroid hormone binding
created_by: ab
creation_date: 2013-04-11T08:34:38Z

[Term]
id: GO:1902053
name: regulation of neosartoricin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neosartoricin biosynthetic process." [GOC:di, GOC:TermGenie, PMID:23368997]
synonym: "regulation of neosartoricin anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of neosartoricin biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of neosartoricin formation" EXACT [GOC:TermGenie]
synonym: "regulation of neosartoricin synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900732 ! regulation of polyketide biosynthetic process
is_a: GO:1902930 ! regulation of alcohol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1902050 ! neosartoricin biosynthetic process
relationship: regulates GO:1902050 ! neosartoricin biosynthetic process
created_by: di
creation_date: 2013-04-11T15:46:06Z

[Term]
id: GO:1902054
name: negative regulation of neosartoricin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of neosartoricin biosynthetic process." [GOC:di, GOC:TermGenie, PMID:23368997]
synonym: "down regulation of neosartoricin anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of neosartoricin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of neosartoricin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of neosartoricin formation" EXACT [GOC:TermGenie]
synonym: "down regulation of neosartoricin synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of neosartoricin anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of neosartoricin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of neosartoricin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of neosartoricin formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of neosartoricin synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of neosartoricin anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of neosartoricin biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of neosartoricin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of neosartoricin formation" EXACT [GOC:TermGenie]
synonym: "downregulation of neosartoricin synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of neosartoricin anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of neosartoricin biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of neosartoricin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of neosartoricin formation" EXACT [GOC:TermGenie]
synonym: "inhibition of neosartoricin synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of neosartoricin anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of neosartoricin biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of neosartoricin formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of neosartoricin synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900733 ! negative regulation of polyketide biosynthetic process
is_a: GO:1902053 ! regulation of neosartoricin biosynthetic process
is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1902050 ! neosartoricin biosynthetic process
relationship: negatively_regulates GO:1902050 ! neosartoricin biosynthetic process
created_by: di
creation_date: 2013-04-11T15:46:15Z

[Term]
id: GO:1902055
name: positive regulation of neosartoricin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neosartoricin biosynthetic process." [GOC:di, GOC:TermGenie, PMID:23368997]
synonym: "activation of neosartoricin anabolism" EXACT [GOC:TermGenie]
synonym: "activation of neosartoricin biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of neosartoricin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of neosartoricin formation" EXACT [GOC:TermGenie]
synonym: "activation of neosartoricin synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of neosartoricin anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of neosartoricin biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of neosartoricin formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of neosartoricin synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of neosartoricin anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of neosartoricin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of neosartoricin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of neosartoricin formation" EXACT [GOC:TermGenie]
synonym: "up regulation of neosartoricin synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of neosartoricin anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of neosartoricin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of neosartoricin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of neosartoricin formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of neosartoricin synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of neosartoricin anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of neosartoricin biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of neosartoricin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of neosartoricin formation" EXACT [GOC:TermGenie]
synonym: "upregulation of neosartoricin synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900734 ! positive regulation of polyketide biosynthetic process
is_a: GO:1902053 ! regulation of neosartoricin biosynthetic process
is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1902050 ! neosartoricin biosynthetic process
relationship: positively_regulates GO:1902050 ! neosartoricin biosynthetic process
created_by: di
creation_date: 2013-04-11T15:46:20Z

[Term]
id: GO:1902056
name: (25S)-Delta(7)-dafachronate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (25S)-Delta(7)-dafachronate." [GOC:TermGenie, PMID:22505847]
synonym: "(25S)-Delta(7)-dafachronate metabolism" EXACT [GOC:TermGenie]
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042180 ! cellular ketone metabolic process
created_by: ab
creation_date: 2013-04-13T09:05:27Z

[Term]
id: GO:1902057
name: (25S)-Delta(4)-dafachronate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (25S)-Delta(4)-dafachronate." [GOC:TermGenie, PMID:20178781]
synonym: "(25S)-Delta(4)-dafachronate metabolism" EXACT [GOC:TermGenie]
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042180 ! cellular ketone metabolic process
created_by: ab
creation_date: 2013-04-13T09:22:54Z

[Term]
id: GO:1902058
name: regulation of sporocarp development involved in sexual reproduction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sporocarp development involved in sexual reproduction." [GOC:di, GOC:TermGenie, PMID:23480775]
synonym: "regulation of ascus development" NARROW [GOC:TermGenie]
synonym: "regulation of fruiting body development involved in sexual reproduction" BROAD [GOC:TermGenie]
synonym: "regulation of fruiting body formation involved in sexual reproduction" BROAD [GOC:TermGenie]
synonym: "regulation of perfect stage fruiting body development" NARROW [GOC:TermGenie]
is_a: GO:0031155 ! regulation of fruiting body development
is_a: GO:0043900 ! regulation of multi-organism process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000909 ! sporocarp development involved in sexual reproduction
relationship: regulates GO:0000909 ! sporocarp development involved in sexual reproduction
created_by: di
creation_date: 2013-04-16T04:08:38Z

[Term]
id: GO:1902059
name: negative regulation of sporocarp development involved in sexual reproduction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sporocarp development involved in sexual reproduction." [GOC:di, GOC:TermGenie, PMID:23480775]
synonym: "down regulation of ascus development" NARROW [GOC:TermGenie]
synonym: "down regulation of fruiting body development involved in sexual reproduction" BROAD [GOC:TermGenie]
synonym: "down regulation of fruiting body formation involved in sexual reproduction" BROAD [GOC:TermGenie]
synonym: "down regulation of perfect stage fruiting body development" NARROW [GOC:TermGenie]
synonym: "down regulation of sporocarp development involved in sexual reproduction" EXACT [GOC:TermGenie]
synonym: "down-regulation of ascus development" NARROW [GOC:TermGenie]
synonym: "down-regulation of fruiting body development involved in sexual reproduction" BROAD [GOC:TermGenie]
synonym: "down-regulation of fruiting body formation involved in sexual reproduction" BROAD [GOC:TermGenie]
synonym: "down-regulation of perfect stage fruiting body development" NARROW [GOC:TermGenie]
synonym: "down-regulation of sporocarp development involved in sexual reproduction" EXACT [GOC:TermGenie]
synonym: "downregulation of ascus development" NARROW [GOC:TermGenie]
synonym: "downregulation of fruiting body development involved in sexual reproduction" BROAD [GOC:TermGenie]
synonym: "downregulation of fruiting body formation involved in sexual reproduction" BROAD [GOC:TermGenie]
synonym: "downregulation of perfect stage fruiting body development" NARROW [GOC:TermGenie]
synonym: "downregulation of sporocarp development involved in sexual reproduction" EXACT [GOC:TermGenie]
synonym: "inhibition of ascus development" NARROW [GOC:TermGenie]
synonym: "inhibition of fruiting body development involved in sexual reproduction" BROAD [GOC:TermGenie]
synonym: "inhibition of fruiting body formation involved in sexual reproduction" BROAD [GOC:TermGenie]
synonym: "inhibition of perfect stage fruiting body development" NARROW [GOC:TermGenie]
synonym: "inhibition of sporocarp development involved in sexual reproduction" NARROW [GOC:TermGenie]
synonym: "negative regulation of ascus development" NARROW [GOC:TermGenie]
synonym: "negative regulation of fruiting body development involved in sexual reproduction" BROAD [GOC:TermGenie]
synonym: "negative regulation of fruiting body formation involved in sexual reproduction" BROAD [GOC:TermGenie]
synonym: "negative regulation of perfect stage fruiting body development" NARROW [GOC:TermGenie]
is_a: GO:0043901 ! negative regulation of multi-organism process
is_a: GO:0075262 ! negative regulation of spore-bearing organ development
is_a: GO:1902058 ! regulation of sporocarp development involved in sexual reproduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000909 ! sporocarp development involved in sexual reproduction
relationship: negatively_regulates GO:0000909 ! sporocarp development involved in sexual reproduction
created_by: di
creation_date: 2013-04-16T04:08:42Z

[Term]
id: GO:1902060
name: positive regulation of sporocarp development involved in sexual reproduction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sporocarp development involved in sexual reproduction." [GOC:di, GOC:TermGenie, PMID:23480775]
synonym: "activation of ascus development" NARROW [GOC:TermGenie]
synonym: "activation of fruiting body development involved in sexual reproduction" BROAD [GOC:TermGenie]
synonym: "activation of fruiting body formation involved in sexual reproduction" BROAD [GOC:TermGenie]
synonym: "activation of perfect stage fruiting body development" NARROW [GOC:TermGenie]
synonym: "activation of sporocarp development involved in sexual reproduction" NARROW [GOC:TermGenie]
synonym: "positive regulation of ascus development" NARROW [GOC:TermGenie]
synonym: "positive regulation of fruiting body development involved in sexual reproduction" BROAD [GOC:TermGenie]
synonym: "positive regulation of fruiting body formation involved in sexual reproduction" BROAD [GOC:TermGenie]
synonym: "positive regulation of perfect stage fruiting body development" NARROW [GOC:TermGenie]
synonym: "up regulation of ascus development" NARROW [GOC:TermGenie]
synonym: "up regulation of fruiting body development involved in sexual reproduction" BROAD [GOC:TermGenie]
synonym: "up regulation of fruiting body formation involved in sexual reproduction" BROAD [GOC:TermGenie]
synonym: "up regulation of perfect stage fruiting body development" NARROW [GOC:TermGenie]
synonym: "up regulation of sporocarp development involved in sexual reproduction" EXACT [GOC:TermGenie]
synonym: "up-regulation of ascus development" NARROW [GOC:TermGenie]
synonym: "up-regulation of fruiting body development involved in sexual reproduction" BROAD [GOC:TermGenie]
synonym: "up-regulation of fruiting body formation involved in sexual reproduction" BROAD [GOC:TermGenie]
synonym: "up-regulation of perfect stage fruiting body development" NARROW [GOC:TermGenie]
synonym: "up-regulation of sporocarp development involved in sexual reproduction" EXACT [GOC:TermGenie]
synonym: "upregulation of ascus development" NARROW [GOC:TermGenie]
synonym: "upregulation of fruiting body development involved in sexual reproduction" BROAD [GOC:TermGenie]
synonym: "upregulation of fruiting body formation involved in sexual reproduction" BROAD [GOC:TermGenie]
synonym: "upregulation of perfect stage fruiting body development" NARROW [GOC:TermGenie]
synonym: "upregulation of sporocarp development involved in sexual reproduction" EXACT [GOC:TermGenie]
is_a: GO:0043902 ! positive regulation of multi-organism process
is_a: GO:0075261 ! positive regulation of spore-bearing organ development
is_a: GO:1902058 ! regulation of sporocarp development involved in sexual reproduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000909 ! sporocarp development involved in sexual reproduction
relationship: positively_regulates GO:0000909 ! sporocarp development involved in sexual reproduction
created_by: di
creation_date: 2013-04-16T04:08:47Z

[Term]
id: GO:1902061
name: betaine aldehyde metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving betaine aldehyde." [GOC:di, GOC:TermGenie, PMID:23563483]
synonym: "betaine aldehyde metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006081 ! cellular aldehyde metabolic process
is_a: GO:0097164 ! ammonium ion metabolic process
created_by: di
creation_date: 2013-04-16T12:07:03Z

[Term]
id: GO:1902062
name: betaine aldehyde catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of betaine aldehyde." [GOC:di, GOC:TermGenie, PMID:23563483]
synonym: "betaine aldehyde breakdown" EXACT [GOC:TermGenie]
synonym: "betaine aldehyde catabolism" EXACT [GOC:TermGenie]
synonym: "betaine aldehyde degradation" EXACT [GOC:TermGenie]
is_a: GO:0046185 ! aldehyde catabolic process
is_a: GO:1902061 ! betaine aldehyde metabolic process
created_by: di
creation_date: 2013-04-16T12:07:12Z

[Term]
id: GO:1902063
name: betaine aldehyde biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of betaine aldehyde." [GOC:di, GOC:TermGenie, PMID:23563483]
synonym: "betaine aldehyde anabolism" EXACT [GOC:TermGenie]
synonym: "betaine aldehyde biosynthesis" EXACT [GOC:TermGenie]
synonym: "betaine aldehyde formation" EXACT [GOC:TermGenie]
synonym: "betaine aldehyde synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046184 ! aldehyde biosynthetic process
is_a: GO:1902061 ! betaine aldehyde metabolic process
created_by: di
creation_date: 2013-04-16T12:07:17Z

[Term]
id: GO:1902064
name: regulation of transcription from RNA polymerase II promoter involved in spermatogenesis
namespace: biological_process
def: "Any regulation of transcription from RNA polymerase II promoter that is involved in spermatogenesis." [GOC:kmv, GOC:TermGenie, PMID:22570621]
synonym: "global transcription regulation from Pol II promoter involved in generation of spermatozoa" RELATED [GOC:TermGenie]
synonym: "global transcription regulation from Pol II promoter involved in spermatogenesis" RELATED [GOC:TermGenie]
synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in generation of spermatozoa" RELATED [GOC:TermGenie]
synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in spermatogenesis" RELATED [GOC:TermGenie]
synonym: "regulation of global transcription from Pol II promoter involved in generation of spermatozoa" RELATED [GOC:TermGenie]
synonym: "regulation of global transcription from Pol II promoter involved in spermatogenesis" RELATED [GOC:TermGenie]
synonym: "regulation of transcription from Pol II promoter involved in generation of spermatozoa" EXACT [GOC:TermGenie]
synonym: "regulation of transcription from Pol II promoter involved in spermatogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter involved in generation of spermatozoa" EXACT [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter, global involved in generation of spermatozoa" RELATED [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter, global involved in spermatogenesis" RELATED [GOC:TermGenie]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0022414 ! reproductive process
intersection_of: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
intersection_of: part_of GO:0007283 ! spermatogenesis
relationship: part_of GO:0007283 ! spermatogenesis
created_by: kmv
creation_date: 2013-04-16T20:27:18Z

[Term]
id: GO:1902065
name: response to L-glutamate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an L-glutamate stimulus." [GOC:TermGenie, PMID:23574009]
is_a: GO:0043200 ! response to amino acid
created_by: tb
creation_date: 2013-04-16T21:21:14Z

[Term]
id: GO:1902066
name: regulation of cell wall pectin metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell wall pectin metabolic process." [GOC:TermGenie, PMID:23453954]
synonym: "regulation of cell wall pectin metabolism" EXACT [GOC:TermGenie]
synonym: "regulation of cellulose and pectin-containing cell wall pectin metabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of pectin metabolism during cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of plant-type cell wall pectin metabolic process" EXACT [GOC:TermGenie]
is_a: GO:0032881 ! regulation of polysaccharide metabolic process
is_a: GO:0051128 ! regulation of cellular component organization
is_a: GO:1903338 ! regulation of cell wall organization or biogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0052546 ! cell wall pectin metabolic process
relationship: regulates GO:0052546 ! cell wall pectin metabolic process
created_by: tb
creation_date: 2013-04-17T20:05:56Z

[Term]
id: GO:1902067
name: silicic acid import
namespace: biological_process
def: "The directed movement of silicic acid into a cell or organelle. Silicic acid is the bioavailable form of silicon." [GOC:TermGenie, PMID:15753109]
synonym: "silicon uptake" RELATED []
is_a: GO:0015708 ! silicate transport
created_by: tb
creation_date: 2013-04-17T20:53:16Z

[Term]
id: GO:1902068
name: regulation of sphingolipid mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sphingolipid signaling." [GOC:TermGenie, PMID:20870412]
synonym: "regulation of sphingolipid signaling pathway" RELATED [GOC:TermGenie]
is_a: GO:0009966 ! regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0090520 ! sphingolipid mediated signaling pathway
relationship: regulates GO:0090520 ! sphingolipid mediated signaling pathway
created_by: bf
creation_date: 2013-04-18T13:24:47Z

[Term]
id: GO:1902069
name: negative regulation of sphingolipid mediated signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sphingolipid signaling." [GOC:TermGenie, PMID:20870412]
synonym: "down regulation of sphingolipid mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of sphingolipid signaling pathway" RELATED [GOC:TermGenie]
synonym: "down-regulation of sphingolipid mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of sphingolipid signaling pathway" RELATED [GOC:TermGenie]
synonym: "downregulation of sphingolipid mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of sphingolipid signaling pathway" RELATED [GOC:TermGenie]
synonym: "inhibition of sphingolipid mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of sphingolipid signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of sphingolipid signaling pathway" RELATED [GOC:TermGenie]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:1902068 ! regulation of sphingolipid mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0090520 ! sphingolipid mediated signaling pathway
relationship: negatively_regulates GO:0090520 ! sphingolipid mediated signaling pathway
created_by: bf
creation_date: 2013-04-18T13:24:51Z

[Term]
id: GO:1902070
name: positive regulation of sphingolipid mediated signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sphingolipid signaling." [GOC:TermGenie, PMID:20870412]
synonym: "activation of sphingolipid mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of sphingolipid signaling pathway" RELATED [GOC:TermGenie]
synonym: "positive regulation of sphingolipid signaling pathway" RELATED [GOC:TermGenie]
synonym: "up regulation of sphingolipid mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of sphingolipid signaling pathway" RELATED [GOC:TermGenie]
synonym: "up-regulation of sphingolipid mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of sphingolipid signaling pathway" RELATED [GOC:TermGenie]
synonym: "upregulation of sphingolipid mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of sphingolipid signaling pathway" RELATED [GOC:TermGenie]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:1902068 ! regulation of sphingolipid mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0090520 ! sphingolipid mediated signaling pathway
relationship: positively_regulates GO:0090520 ! sphingolipid mediated signaling pathway
created_by: bf
creation_date: 2013-04-18T13:24:56Z

[Term]
id: GO:1902071
name: regulation of hypoxia-inducible factor-1alpha signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hypoxia-inducible factor-1alpha signaling pathway." [GOC:bf, GOC:TermGenie]
synonym: "regulation of HIF1alpha pathway" EXACT [GOC:TermGenie]
synonym: "regulation of hypoxia-inducible factor-1alpha signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:1900037 ! regulation of cellular response to hypoxia
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097411 ! hypoxia-inducible factor-1alpha signaling pathway
relationship: regulates GO:0097411 ! hypoxia-inducible factor-1alpha signaling pathway
created_by: bf
creation_date: 2013-04-18T13:28:21Z

[Term]
id: GO:1902072
name: negative regulation of hypoxia-inducible factor-1alpha signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hypoxia-inducible factor-1alpha signaling pathway." [GOC:bf, GOC:TermGenie]
synonym: "down regulation of HIF1alpha pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of hypoxia-inducible factor-1alpha signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of hypoxia-inducible factor-1alpha signalling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of HIF1alpha pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of hypoxia-inducible factor-1alpha signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of hypoxia-inducible factor-1alpha signalling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of HIF1alpha pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of hypoxia-inducible factor-1alpha signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of hypoxia-inducible factor-1alpha signalling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of HIF1alpha pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of hypoxia-inducible factor-1alpha signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of hypoxia-inducible factor-1alpha signalling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of HIF1alpha pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of hypoxia-inducible factor-1alpha signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:1900038 ! negative regulation of cellular response to hypoxia
is_a: GO:1902071 ! regulation of hypoxia-inducible factor-1alpha signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097411 ! hypoxia-inducible factor-1alpha signaling pathway
relationship: negatively_regulates GO:0097411 ! hypoxia-inducible factor-1alpha signaling pathway
created_by: bf
creation_date: 2013-04-18T13:28:25Z

[Term]
id: GO:1902073
name: positive regulation of hypoxia-inducible factor-1alpha signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hypoxia-inducible factor-1alpha signaling pathway." [GOC:bf, GOC:TermGenie, PMID:21685248]
synonym: "activation of HIF1alpha pathway" EXACT [GOC:TermGenie]
synonym: "activation of hypoxia-inducible factor-1alpha signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of hypoxia-inducible factor-1alpha signalling pathway" EXACT [GOC:TermGenie]
synonym: "hypoxic stabilization of HIF1A" NARROW []
synonym: "positive regulation of HIF1alpha pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of hypoxia-inducible factor-1alpha signalling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of HIF1alpha pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of hypoxia-inducible factor-1alpha signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of hypoxia-inducible factor-1alpha signalling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of HIF1alpha pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of hypoxia-inducible factor-1alpha signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of hypoxia-inducible factor-1alpha signalling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of HIF1alpha pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of hypoxia-inducible factor-1alpha signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of hypoxia-inducible factor-1alpha signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:1900039 ! positive regulation of cellular response to hypoxia
is_a: GO:1902071 ! regulation of hypoxia-inducible factor-1alpha signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097411 ! hypoxia-inducible factor-1alpha signaling pathway
relationship: positively_regulates GO:0097411 ! hypoxia-inducible factor-1alpha signaling pathway
created_by: bf
creation_date: 2013-04-18T13:28:30Z

[Term]
id: GO:1902074
name: response to salt
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus." [GOC:mls, GOC:TermGenie, PMID:16666921]
synonym: "response to salinity" NARROW [GOC:mls]
is_a: GO:0042221 ! response to chemical
created_by: mls
creation_date: 2013-04-22T15:41:57Z

[Term]
id: GO:1902075
name: cellular response to salt
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus." [GOC:mls, GOC:TermGenie, PMID:16666921]
synonym: "cellular response to salinity" NARROW [GOC:mls]
is_a: GO:0070887 ! cellular response to chemical stimulus
is_a: GO:1902074 ! response to salt
created_by: mls
creation_date: 2013-04-22T15:42:02Z

[Term]
id: GO:1902076
name: regulation of lateral motor column neuron migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lateral motor column neuron migration." [GOC:TermGenie, GOC:yaf, PMID:20711475]
is_a: GO:2001222 ! regulation of neuron migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097477 ! lateral motor column neuron migration
relationship: regulates GO:0097477 ! lateral motor column neuron migration
created_by: pr
creation_date: 2013-04-23T14:42:18Z

[Term]
id: GO:1902077
name: negative regulation of lateral motor column neuron migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lateral motor column neuron migration." [GOC:TermGenie, GOC:yaf, PMID:20711475]
synonym: "down regulation of lateral motor column neuron migration" EXACT [GOC:TermGenie]
synonym: "down-regulation of lateral motor column neuron migration" EXACT [GOC:TermGenie]
synonym: "downregulation of lateral motor column neuron migration" EXACT [GOC:TermGenie]
synonym: "inhibition of lateral motor column neuron migration" NARROW [GOC:TermGenie]
is_a: GO:1902076 ! regulation of lateral motor column neuron migration
is_a: GO:2001223 ! negative regulation of neuron migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097477 ! lateral motor column neuron migration
relationship: negatively_regulates GO:0097477 ! lateral motor column neuron migration
created_by: pr
creation_date: 2013-04-23T14:42:23Z

[Term]
id: GO:1902078
name: positive regulation of lateral motor column neuron migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lateral motor column neuron migration." [GOC:TermGenie, GOC:yaf, PMID:20711475]
synonym: "activation of lateral motor column neuron migration" NARROW [GOC:TermGenie]
synonym: "up regulation of lateral motor column neuron migration" EXACT [GOC:TermGenie]
synonym: "up-regulation of lateral motor column neuron migration" EXACT [GOC:TermGenie]
synonym: "upregulation of lateral motor column neuron migration" EXACT [GOC:TermGenie]
is_a: GO:1902076 ! regulation of lateral motor column neuron migration
is_a: GO:2001224 ! positive regulation of neuron migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097477 ! lateral motor column neuron migration
relationship: positively_regulates GO:0097477 ! lateral motor column neuron migration
created_by: pr
creation_date: 2013-04-23T14:42:28Z

[Term]
id: GO:1902079
name: D-valine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-valine." [GOC:TermGenie, PMID:23085840]
synonym: "D-valine breakdown" EXACT [GOC:TermGenie]
synonym: "D-valine catabolism" EXACT [GOC:TermGenie]
synonym: "D-valine degradation" EXACT [GOC:TermGenie]
is_a: GO:0006574 ! valine catabolic process
is_a: GO:0019478 ! D-amino acid catabolic process
is_a: GO:1902114 ! D-valine metabolic process
created_by: al
creation_date: 2013-04-23T21:34:29Z

[Term]
id: GO:1902080
name: regulation of calcium ion import into sarcoplasmic reticulum
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of calcium ion import into sarcoplasmic reticulum." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:8349590]
is_a: GO:0090279 ! regulation of calcium ion import
is_a: GO:1903649 ! regulation of cytoplasmic transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990036 ! calcium ion import into sarcoplasmic reticulum
relationship: regulates GO:1990036 ! calcium ion import into sarcoplasmic reticulum
created_by: rl
creation_date: 2013-04-24T16:07:50Z

[Term]
id: GO:1902081
name: negative regulation of calcium ion import into sarcoplasmic reticulum
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion import into sarcoplasmic reticulum." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:8349590]
synonym: "down regulation of calcium ion import into sarcoplasmic reticulum" EXACT [GOC:TermGenie]
synonym: "down-regulation of calcium ion import into sarcoplasmic reticulum" EXACT [GOC:TermGenie]
synonym: "downregulation of calcium ion import into sarcoplasmic reticulum" EXACT [GOC:TermGenie]
synonym: "inhibition of calcium ion import into sarcoplasmic reticulum" NARROW [GOC:TermGenie]
is_a: GO:0090281 ! negative regulation of calcium ion import
is_a: GO:1902080 ! regulation of calcium ion import into sarcoplasmic reticulum
is_a: GO:1903650 ! negative regulation of cytoplasmic transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990036 ! calcium ion import into sarcoplasmic reticulum
relationship: negatively_regulates GO:1990036 ! calcium ion import into sarcoplasmic reticulum
created_by: rl
creation_date: 2013-04-24T16:07:59Z

[Term]
id: GO:1902082
name: positive regulation of calcium ion import into sarcoplasmic reticulum
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of calcium ion import into sarcoplasmic reticulum." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:8349590]
synonym: "activation of calcium ion import into sarcoplasmic reticulum" NARROW [GOC:TermGenie]
synonym: "up regulation of calcium ion import into sarcoplasmic reticulum" EXACT [GOC:TermGenie]
synonym: "up-regulation of calcium ion import into sarcoplasmic reticulum" EXACT [GOC:TermGenie]
synonym: "upregulation of calcium ion import into sarcoplasmic reticulum" EXACT [GOC:TermGenie]
is_a: GO:0090280 ! positive regulation of calcium ion import
is_a: GO:1902080 ! regulation of calcium ion import into sarcoplasmic reticulum
is_a: GO:1903651 ! positive regulation of cytoplasmic transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990036 ! calcium ion import into sarcoplasmic reticulum
relationship: positively_regulates GO:1990036 ! calcium ion import into sarcoplasmic reticulum
created_by: rl
creation_date: 2013-04-24T16:08:03Z

[Term]
id: GO:1902083
name: negative regulation of peptidyl-cysteine S-nitrosylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-cysteine S-nitrosylation." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19198614]
synonym: "down regulation of peptidyl-cysteine S-nitrosylation" EXACT [GOC:TermGenie]
synonym: "down regulation of protein S-nitrosylation" EXACT [GOC:TermGenie]
synonym: "down regulation of S-nitrosylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of peptidyl-cysteine S-nitrosylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein S-nitrosylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of S-nitrosylation" EXACT [GOC:TermGenie]
synonym: "downregulation of peptidyl-cysteine S-nitrosylation" EXACT [GOC:TermGenie]
synonym: "downregulation of protein S-nitrosylation" EXACT [GOC:TermGenie]
synonym: "downregulation of S-nitrosylation" EXACT [GOC:TermGenie]
synonym: "inhibition of peptidyl-cysteine S-nitrosylation" NARROW [GOC:TermGenie]
synonym: "inhibition of protein S-nitrosylation" EXACT [GOC:TermGenie]
synonym: "inhibition of S-nitrosylation" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein S-nitrosylation" EXACT [GOC:TermGenie]
synonym: "negative regulation of S-nitrosylation" EXACT [GOC:TermGenie]
is_a: GO:0031400 ! negative regulation of protein modification process
is_a: GO:2000169 ! regulation of peptidyl-cysteine S-nitrosylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0018119 ! peptidyl-cysteine S-nitrosylation
relationship: negatively_regulates GO:0018119 ! peptidyl-cysteine S-nitrosylation
created_by: rl
creation_date: 2013-04-24T16:49:34Z

[Term]
id: GO:1902084
name: fumagillin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fumagillin." [GOC:di, GOC:TermGenie, PMID:23488861]
synonym: "fumagillin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019752 ! carboxylic acid metabolic process
is_a: GO:0097176 ! epoxide metabolic process
created_by: di
creation_date: 2013-04-25T14:00:41Z

[Term]
id: GO:1902085
name: fumagillin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of fumagillin." [GOC:di, GOC:TermGenie, PMID:23488861]
synonym: "fumagillin breakdown" EXACT [GOC:TermGenie]
synonym: "fumagillin catabolism" EXACT [GOC:TermGenie]
synonym: "fumagillin degradation" EXACT [GOC:TermGenie]
is_a: GO:0046395 ! carboxylic acid catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901502 ! ether catabolic process
is_a: GO:1902084 ! fumagillin metabolic process
created_by: di
creation_date: 2013-04-25T14:00:45Z

[Term]
id: GO:1902086
name: fumagillin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of fumagillin." [GOC:di, GOC:TermGenie, PMID:23488861]
synonym: "fumagillin anabolism" EXACT [GOC:TermGenie]
synonym: "fumagillin biosynthesis" EXACT [GOC:TermGenie]
synonym: "fumagillin formation" EXACT [GOC:TermGenie]
synonym: "fumagillin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901503 ! ether biosynthetic process
is_a: GO:1902084 ! fumagillin metabolic process
created_by: di
creation_date: 2013-04-25T14:00:50Z

[Term]
id: GO:1902087
name: dimethylsulfoniopropionate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of S,S-dimethyl-beta-propiothetin." [GOC:jh2, GOC:TermGenie, PMID:19807777]
synonym: "S,S-dimethyl-beta-propiothetin breakdown" EXACT [GOC:TermGenie]
synonym: "S,S-dimethyl-beta-propiothetin catabolic process" EXACT []
synonym: "S,S-dimethyl-beta-propiothetin catabolism" EXACT [GOC:TermGenie]
synonym: "S,S-dimethyl-beta-propiothetin degradation" EXACT [GOC:TermGenie]
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:1901575 ! organic substance catabolic process
created_by: tb
creation_date: 2013-04-26T17:29:13Z

[Term]
id: GO:1902088
name: plant-type cell wall loosening involved in abscission
namespace: biological_process
def: "Any plant-type cell wall loosening that is involved in abscission." [GOC:TermGenie, PMID:23479623]
synonym: "cellulose and pectin-containing cell wall loosening involved in abscission" EXACT [GOC:TermGenie]
is_a: GO:0009828 ! plant-type cell wall loosening
is_a: GO:0009830 ! cell wall modification involved in abscission
intersection_of: GO:0009828 ! plant-type cell wall loosening
intersection_of: part_of GO:0009838 ! abscission
relationship: part_of GO:0009838 ! abscission
created_by: tb
creation_date: 2013-04-26T18:34:45Z

[Term]
id: GO:1902089
name: cell wall polysaccharide catabolic process involved in lateral root development
namespace: biological_process
def: "Any cell wall polysaccharide catabolic process that is involved in lateral root development." [GOC:TermGenie, PMID:23479623]
synonym: "cell wall polysaccharide breakdown involved in lateral root development" EXACT [GOC:TermGenie]
is_a: GO:0044347 ! cell wall polysaccharide catabolic process
intersection_of: GO:0044347 ! cell wall polysaccharide catabolic process
intersection_of: part_of GO:0048527 ! lateral root development
relationship: part_of GO:0048527 ! lateral root development
created_by: tb
creation_date: 2013-04-26T18:34:53Z

[Term]
id: GO:1902090
name: regulation of fumagillin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fumagillin biosynthetic process." [GOC:di, GOC:TermGenie, PMID:23488861]
synonym: "regulation of fumagillin anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of fumagillin biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of fumagillin formation" EXACT [GOC:TermGenie]
synonym: "regulation of fumagillin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0043455 ! regulation of secondary metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1902086 ! fumagillin biosynthetic process
relationship: regulates GO:1902086 ! fumagillin biosynthetic process
created_by: di
creation_date: 2013-04-27T03:44:59Z

[Term]
id: GO:1902091
name: negative regulation of fumagillin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of fumagillin biosynthetic process." [GOC:di, GOC:TermGenie, PMID:23488861]
synonym: "down regulation of fumagillin anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of fumagillin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of fumagillin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of fumagillin formation" EXACT [GOC:TermGenie]
synonym: "down regulation of fumagillin synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of fumagillin anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of fumagillin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of fumagillin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of fumagillin formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of fumagillin synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of fumagillin anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of fumagillin biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of fumagillin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of fumagillin formation" EXACT [GOC:TermGenie]
synonym: "downregulation of fumagillin synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of fumagillin anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of fumagillin biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of fumagillin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of fumagillin formation" EXACT [GOC:TermGenie]
synonym: "inhibition of fumagillin synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of fumagillin anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of fumagillin biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of fumagillin formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of fumagillin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:1902090 ! regulation of fumagillin biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1902086 ! fumagillin biosynthetic process
relationship: negatively_regulates GO:1902086 ! fumagillin biosynthetic process
created_by: di
creation_date: 2013-04-27T03:45:04Z

[Term]
id: GO:1902092
name: positive regulation of fumagillin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of fumagillin biosynthetic process." [GOC:di, GOC:TermGenie, PMID:23488861]
synonym: "activation of fumagillin anabolism" EXACT [GOC:TermGenie]
synonym: "activation of fumagillin biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of fumagillin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of fumagillin formation" EXACT [GOC:TermGenie]
synonym: "activation of fumagillin synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of fumagillin anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of fumagillin biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of fumagillin formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of fumagillin synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of fumagillin anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of fumagillin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of fumagillin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of fumagillin formation" EXACT [GOC:TermGenie]
synonym: "up regulation of fumagillin synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of fumagillin anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of fumagillin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of fumagillin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of fumagillin formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of fumagillin synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of fumagillin anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of fumagillin biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of fumagillin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of fumagillin formation" EXACT [GOC:TermGenie]
synonym: "upregulation of fumagillin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:1902090 ! regulation of fumagillin biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1902086 ! fumagillin biosynthetic process
relationship: positively_regulates GO:1902086 ! fumagillin biosynthetic process
created_by: di
creation_date: 2013-04-27T03:45:09Z

[Term]
id: GO:1902093
name: positive regulation of sperm motility
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sperm motility." [GOC:jh2, GOC:TermGenie, PMID:7513657]
synonym: "activation of sperm motility" NARROW [GOC:TermGenie]
synonym: "activation of sperm movement" EXACT [GOC:TermGenie]
synonym: "positive regulation of sperm movement" EXACT [GOC:TermGenie]
synonym: "up regulation of sperm motility" EXACT [GOC:TermGenie]
synonym: "up regulation of sperm movement" EXACT [GOC:TermGenie]
synonym: "up-regulation of sperm motility" EXACT [GOC:TermGenie]
synonym: "up-regulation of sperm movement" EXACT [GOC:TermGenie]
synonym: "upregulation of sperm motility" EXACT [GOC:TermGenie]
synonym: "upregulation of sperm movement" EXACT [GOC:TermGenie]
is_a: GO:1901317 ! regulation of sperm motility
is_a: GO:2000147 ! positive regulation of cell motility
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030317 ! sperm motility
relationship: positively_regulates GO:0030317 ! sperm motility
created_by: bf
creation_date: 2013-04-29T09:15:25Z

[Term]
id: GO:1902094
name: regulation of cartilage homeostasis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cartilage homeostasis." [GOC:hjd, GOC:TermGenie, PMID:21652695]
is_a: GO:0032844 ! regulation of homeostatic process
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990079 ! cartilage homeostasis
relationship: regulates GO:1990079 ! cartilage homeostasis
created_by: hjd
creation_date: 2013-04-30T13:47:23Z

[Term]
id: GO:1902095
name: negative regulation of cartilage homeostasis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cartilage homeostasis." [GOC:hjd, GOC:TermGenie, PMID:21652695]
synonym: "down regulation of cartilage homeostasis" EXACT [GOC:TermGenie]
synonym: "down-regulation of cartilage homeostasis" EXACT [GOC:TermGenie]
synonym: "downregulation of cartilage homeostasis" EXACT [GOC:TermGenie]
synonym: "inhibition of cartilage homeostasis" NARROW [GOC:TermGenie]
is_a: GO:0032845 ! negative regulation of homeostatic process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1902094 ! regulation of cartilage homeostasis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990079 ! cartilage homeostasis
relationship: negatively_regulates GO:1990079 ! cartilage homeostasis
created_by: hjd
creation_date: 2013-04-30T13:47:31Z

[Term]
id: GO:1902096
name: positive regulation of cartilage homeostasis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cartilage homeostasis." [GOC:hjd, GOC:TermGenie, PMID:21652695]
synonym: "activation of cartilage homeostasis" NARROW [GOC:TermGenie]
synonym: "up regulation of cartilage homeostasis" EXACT [GOC:TermGenie]
synonym: "up-regulation of cartilage homeostasis" EXACT [GOC:TermGenie]
synonym: "upregulation of cartilage homeostasis" EXACT [GOC:TermGenie]
is_a: GO:0032846 ! positive regulation of homeostatic process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1902094 ! regulation of cartilage homeostasis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990079 ! cartilage homeostasis
relationship: positively_regulates GO:1990079 ! cartilage homeostasis
created_by: hjd
creation_date: 2013-04-30T13:47:36Z

[Term]
id: GO:1902097
name: positive regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium
namespace: biological_process
def: "Any positive regulation of transcription from RNA polymerase II promoter that is involved in defense response to Gram-negative bacterium." [GOC:kmv, GOC:TermGenie, PMID:17183709]
synonym: "activation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria" RELATED [GOC:TermGenie]
synonym: "activation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium" RELATED [GOC:TermGenie]
synonym: "activation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria" RELATED [GOC:TermGenie]
synonym: "activation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium" RELATED [GOC:TermGenie]
synonym: "activation of global transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria" NARROW [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium" NARROW [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria" NARROW [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium" NARROW [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria" RELATED [GOC:TermGenie]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium" RELATED [GOC:TermGenie]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria" RELATED [GOC:TermGenie]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium" RELATED [GOC:TermGenie]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription from Pol II promoter involved in defence response to Gram-negative bacteria" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription from Pol II promoter involved in defence response to Gram-negative bacterium" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription from Pol II promoter involved in defense response to Gram-negative bacteria" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription from Pol II promoter involved in defense response to Gram-negative bacterium" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription from Pol II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of transcription from Pol II promoter involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription from Pol II promoter involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription from Pol II promoter involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription from Pol II promoter involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription from Pol II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "stimulation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria" NARROW [GOC:TermGenie]
synonym: "stimulation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium" NARROW [GOC:TermGenie]
synonym: "stimulation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria" NARROW [GOC:TermGenie]
synonym: "stimulation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium" NARROW [GOC:TermGenie]
synonym: "stimulation of global transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "stimulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "stimulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "stimulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "stimulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "stimulation of transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "up regulation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria" RELATED [GOC:TermGenie]
synonym: "up regulation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium" RELATED [GOC:TermGenie]
synonym: "up regulation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria" RELATED [GOC:TermGenie]
synonym: "up regulation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium" RELATED [GOC:TermGenie]
synonym: "up regulation of global transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria" RELATED [GOC:TermGenie]
synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium" RELATED [GOC:TermGenie]
synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria" RELATED [GOC:TermGenie]
synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium" RELATED [GOC:TermGenie]
synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "upregulation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria" RELATED [GOC:TermGenie]
synonym: "upregulation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium" RELATED [GOC:TermGenie]
synonym: "upregulation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria" RELATED [GOC:TermGenie]
synonym: "upregulation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium" RELATED [GOC:TermGenie]
synonym: "upregulation of global transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie]
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
intersection_of: part_of GO:0050829 ! defense response to Gram-negative bacterium
relationship: part_of GO:0050829 ! defense response to Gram-negative bacterium
created_by: kmv
creation_date: 2013-04-30T16:54:30Z

[Term]
id: GO:1902098
name: calcitriol binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with calcitriol. Calcitriol (1,25-dihydroxycholecalciferol) is the hormonally active form of vitamin D3." [GOC:TermGenie, PMID:21872797, Wikipedia:Calcitriol_receptor]
synonym: "1,25-dihydroxycholecalciferol binding" EXACT [Wikipedia:Calcitriol]
synonym: "1,25-dihydroxyvitamin D3 binding" EXACT [Wikipedia:Calcitriol]
synonym: "1alpha,25(OH)2 vitamin D3 binding" EXACT [PMID:21872797]
synonym: "1alpha,25(OH)2D3 binding" EXACT [CHEBI:17823]
synonym: "1alpha,25-dihydroxycholecalciferol binding" EXACT [CHEBI:17823]
synonym: "1alpha,25-dihydroxyvitamin D3 binding" EXACT [CHEBI:17823]
synonym: "hormonally active vitamin D3 binding" EXACT [GOC:bf]
is_a: GO:1902271 ! D3 vitamins binding
created_by: bf
creation_date: 2013-05-02T09:41:15Z

[Term]
id: GO:1902099
name: regulation of metaphase/anaphase transition of cell cycle
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of metaphase/anaphase transition of cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie]
is_a: GO:0033045 ! regulation of sister chromatid segregation
is_a: GO:1901987 ! regulation of cell cycle phase transition
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044784 ! metaphase/anaphase transition of cell cycle
relationship: regulates GO:0044784 ! metaphase/anaphase transition of cell cycle
created_by: jl
creation_date: 2013-05-02T12:45:15Z

[Term]
id: GO:1902100
name: negative regulation of metaphase/anaphase transition of cell cycle
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of metaphase/anaphase transition of cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "down regulation of metaphase/anaphase transition of cell cycle" EXACT [GOC:TermGenie]
synonym: "down-regulation of metaphase/anaphase transition of cell cycle" EXACT [GOC:TermGenie]
synonym: "downregulation of metaphase/anaphase transition of cell cycle" EXACT [GOC:TermGenie]
synonym: "inhibition of metaphase/anaphase transition of cell cycle" NARROW [GOC:TermGenie]
is_a: GO:1901988 ! negative regulation of cell cycle phase transition
is_a: GO:1902099 ! regulation of metaphase/anaphase transition of cell cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044784 ! metaphase/anaphase transition of cell cycle
relationship: negatively_regulates GO:0044784 ! metaphase/anaphase transition of cell cycle
created_by: jl
creation_date: 2013-05-02T12:45:20Z

[Term]
id: GO:1902101
name: positive regulation of metaphase/anaphase transition of cell cycle
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of metaphase/anaphase transition of cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "activation of metaphase/anaphase transition of cell cycle" NARROW [GOC:TermGenie]
synonym: "up regulation of metaphase/anaphase transition of cell cycle" EXACT [GOC:TermGenie]
synonym: "up-regulation of metaphase/anaphase transition of cell cycle" EXACT [GOC:TermGenie]
synonym: "upregulation of metaphase/anaphase transition of cell cycle" EXACT [GOC:TermGenie]
is_a: GO:1901989 ! positive regulation of cell cycle phase transition
is_a: GO:1902099 ! regulation of metaphase/anaphase transition of cell cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044784 ! metaphase/anaphase transition of cell cycle
relationship: positively_regulates GO:0044784 ! metaphase/anaphase transition of cell cycle
created_by: jl
creation_date: 2013-05-02T12:45:30Z

[Term]
id: GO:1902102
name: regulation of metaphase/anaphase transition of meiotic cell cycle
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of metaphase/anaphase transition of meiotic cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "regulation of meiotic metaphase/anaphase transition" EXACT [GOC:TermGenie]
is_a: GO:1901993 ! regulation of meiotic cell cycle phase transition
is_a: GO:1902099 ! regulation of metaphase/anaphase transition of cell cycle
is_a: GO:1905132 ! regulation of meiotic chromosome separation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044785 ! metaphase/anaphase transition of meiotic cell cycle
relationship: regulates GO:0044785 ! metaphase/anaphase transition of meiotic cell cycle
created_by: jl
creation_date: 2013-05-02T12:45:38Z

[Term]
id: GO:1902103
name: negative regulation of metaphase/anaphase transition of meiotic cell cycle
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of metaphase/anaphase transition of meiotic cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "down regulation of meiotic metaphase/anaphase transition" EXACT [GOC:TermGenie]
synonym: "down regulation of metaphase/anaphase transition of meiotic cell cycle" EXACT [GOC:TermGenie]
synonym: "down-regulation of meiotic metaphase/anaphase transition" EXACT [GOC:TermGenie]
synonym: "down-regulation of metaphase/anaphase transition of meiotic cell cycle" EXACT [GOC:TermGenie]
synonym: "downregulation of meiotic metaphase/anaphase transition" EXACT [GOC:TermGenie]
synonym: "downregulation of metaphase/anaphase transition of meiotic cell cycle" EXACT [GOC:TermGenie]
synonym: "inhibition of meiotic metaphase/anaphase transition" EXACT [GOC:TermGenie]
synonym: "inhibition of metaphase/anaphase transition of meiotic cell cycle" NARROW [GOC:TermGenie]
synonym: "negative regulation of meiotic metaphase/anaphase transition" EXACT [GOC:TermGenie]
is_a: GO:1901994 ! negative regulation of meiotic cell cycle phase transition
is_a: GO:1902100 ! negative regulation of metaphase/anaphase transition of cell cycle
is_a: GO:1902102 ! regulation of metaphase/anaphase transition of meiotic cell cycle
is_a: GO:1905133 ! negative regulation of meiotic chromosome separation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044785 ! metaphase/anaphase transition of meiotic cell cycle
relationship: negatively_regulates GO:0044785 ! metaphase/anaphase transition of meiotic cell cycle
created_by: jl
creation_date: 2013-05-02T12:45:43Z

[Term]
id: GO:1902104
name: positive regulation of metaphase/anaphase transition of meiotic cell cycle
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of metaphase/anaphase transition of meiotic cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "activation of meiotic metaphase/anaphase transition" EXACT [GOC:TermGenie]
synonym: "activation of metaphase/anaphase transition of meiotic cell cycle" NARROW [GOC:TermGenie]
synonym: "positive regulation of meiotic metaphase/anaphase transition" EXACT [GOC:TermGenie]
synonym: "up regulation of meiotic metaphase/anaphase transition" EXACT [GOC:TermGenie]
synonym: "up regulation of metaphase/anaphase transition of meiotic cell cycle" EXACT [GOC:TermGenie]
synonym: "up-regulation of meiotic metaphase/anaphase transition" EXACT [GOC:TermGenie]
synonym: "up-regulation of metaphase/anaphase transition of meiotic cell cycle" EXACT [GOC:TermGenie]
synonym: "upregulation of meiotic metaphase/anaphase transition" EXACT [GOC:TermGenie]
synonym: "upregulation of metaphase/anaphase transition of meiotic cell cycle" EXACT [GOC:TermGenie]
is_a: GO:1901995 ! positive regulation of meiotic cell cycle phase transition
is_a: GO:1902101 ! positive regulation of metaphase/anaphase transition of cell cycle
is_a: GO:1902102 ! regulation of metaphase/anaphase transition of meiotic cell cycle
is_a: GO:1905134 ! positive regulation of meiotic chromosome separation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044785 ! metaphase/anaphase transition of meiotic cell cycle
relationship: positively_regulates GO:0044785 ! metaphase/anaphase transition of meiotic cell cycle
created_by: jl
creation_date: 2013-05-02T12:45:48Z

[Term]
id: GO:1902105
name: regulation of leukocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of leukocyte differentiation." [GOC:add, GOC:TermGenie]
synonym: "regulation of immune cell differentiation" EXACT [GOC:TermGenie]
synonym: "regulation of leucocyte differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:1903706 ! regulation of hemopoiesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002521 ! leukocyte differentiation
relationship: regulates GO:0002521 ! leukocyte differentiation
created_by: pr
creation_date: 2013-05-02T17:32:42Z

[Term]
id: GO:1902106
name: negative regulation of leukocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte differentiation." [GOC:add, GOC:TermGenie]
synonym: "down regulation of immune cell differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of leucocyte differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of leukocyte differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of immune cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of leucocyte differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of leukocyte differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of immune cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of leucocyte differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of leukocyte differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of immune cell differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of leucocyte differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of leukocyte differentiation" NARROW [GOC:TermGenie]
synonym: "negative regulation of immune cell differentiation" EXACT [GOC:TermGenie]
synonym: "negative regulation of leucocyte differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:1902105 ! regulation of leukocyte differentiation
is_a: GO:1903707 ! negative regulation of hemopoiesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002521 ! leukocyte differentiation
relationship: negatively_regulates GO:0002521 ! leukocyte differentiation
created_by: pr
creation_date: 2013-05-02T17:32:47Z

[Term]
id: GO:1902107
name: positive regulation of leukocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of leukocyte differentiation." [GOC:add, GOC:TermGenie]
synonym: "activation of immune cell differentiation" NARROW [GOC:TermGenie]
synonym: "activation of leucocyte differentiation" NARROW [GOC:TermGenie]
synonym: "activation of leukocyte differentiation" NARROW [GOC:TermGenie]
synonym: "positive regulation of immune cell differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of leucocyte differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of immune cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of leucocyte differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of leukocyte differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of immune cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of leucocyte differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of leukocyte differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of immune cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of leucocyte differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of leukocyte differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:1902105 ! regulation of leukocyte differentiation
is_a: GO:1903708 ! positive regulation of hemopoiesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002521 ! leukocyte differentiation
relationship: positively_regulates GO:0002521 ! leukocyte differentiation
created_by: pr
creation_date: 2013-05-02T17:32:52Z

[Term]
id: GO:1902108
name: regulation of mitochondrial membrane permeability involved in apoptotic process
namespace: biological_process
def: "Any regulation of mitochondrial membrane permeability that is involved in apoptotic process." [GOC:mtg_apoptosis, GOC:pm, GOC:TermGenie, PMID:19168129]
synonym: "regulation of mitochondrial membrane permeability involved in apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of mitochondrial membrane permeability involved in apoptotic cell death" EXACT [GOC:TermGenie]
synonym: "regulation of mitochondrial membrane permeability involved in apoptotic program" NARROW [GOC:TermGenie]
synonym: "regulation of mitochondrial membrane permeability involved in apoptotic programmed cell death" EXACT [GOC:TermGenie]
synonym: "regulation of mitochondrial membrane permeability involved in programmed cell death by apoptosis" EXACT [GOC:TermGenie]
synonym: "regulation of mitochondrial membrane permeability involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie]
synonym: "regulation of mitochondrial membrane permeability involved in type I programmed cell death" NARROW [GOC:TermGenie]
synonym: "regulation of transport across mitochondrial membrane involved in apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of transport across mitochondrial membrane involved in apoptotic cell death" EXACT [GOC:TermGenie]
synonym: "regulation of transport across mitochondrial membrane involved in apoptotic process" EXACT [GOC:TermGenie]
synonym: "regulation of transport across mitochondrial membrane involved in apoptotic program" NARROW [GOC:TermGenie]
synonym: "regulation of transport across mitochondrial membrane involved in apoptotic programmed cell death" EXACT [GOC:TermGenie]
synonym: "regulation of transport across mitochondrial membrane involved in programmed cell death by apoptosis" EXACT [GOC:TermGenie]
synonym: "regulation of transport across mitochondrial membrane involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie]
synonym: "regulation of transport across mitochondrial membrane involved in type I programmed cell death" NARROW [GOC:TermGenie]
is_a: GO:0008637 ! apoptotic mitochondrial changes
is_a: GO:0046902 ! regulation of mitochondrial membrane permeability
intersection_of: GO:0046902 ! regulation of mitochondrial membrane permeability
intersection_of: part_of GO:0006915 ! apoptotic process
relationship: part_of GO:0006915 ! apoptotic process
created_by: pr
creation_date: 2013-05-03T12:09:35Z

[Term]
id: GO:1902109
name: negative regulation of mitochondrial membrane permeability involved in apoptotic process
namespace: biological_process
def: "Any negative regulation of mitochondrial membrane permeability that is involved in apoptotic process." [GOC:mtg_apoptosis, GOC:pm, GOC:TermGenie, PMID:19168129]
synonym: "mitochondrial membrane impermeability involved in apoptosis" RELATED [GOC:TermGenie]
synonym: "mitochondrial membrane impermeability involved in apoptotic cell death" RELATED [GOC:TermGenie]
synonym: "mitochondrial membrane impermeability involved in apoptotic process" RELATED [GOC:TermGenie]
synonym: "mitochondrial membrane impermeability involved in apoptotic program" RELATED [GOC:TermGenie]
synonym: "mitochondrial membrane impermeability involved in apoptotic programmed cell death" RELATED [GOC:TermGenie]
synonym: "mitochondrial membrane impermeability involved in programmed cell death by apoptosis" RELATED [GOC:TermGenie]
synonym: "mitochondrial membrane impermeability involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie]
synonym: "mitochondrial membrane impermeability involved in type I programmed cell death" RELATED [GOC:TermGenie]
synonym: "mitochondrial membrane impermeabilization involved in apoptosis" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane impermeabilization involved in apoptotic cell death" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane impermeabilization involved in apoptotic process" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane impermeabilization involved in apoptotic program" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane impermeabilization involved in apoptotic programmed cell death" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane impermeabilization involved in programmed cell death by apoptosis" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane impermeabilization involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie]
synonym: "mitochondrial membrane impermeabilization involved in type I programmed cell death" NARROW [GOC:TermGenie]
synonym: "negative regulation of mitochondrial membrane permeability involved in apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of mitochondrial membrane permeability involved in apoptotic cell death" EXACT [GOC:TermGenie]
synonym: "negative regulation of mitochondrial membrane permeability involved in apoptotic program" NARROW [GOC:TermGenie]
synonym: "negative regulation of mitochondrial membrane permeability involved in apoptotic programmed cell death" EXACT [GOC:TermGenie]
synonym: "negative regulation of mitochondrial membrane permeability involved in programmed cell death by apoptosis" EXACT [GOC:TermGenie]
synonym: "negative regulation of mitochondrial membrane permeability involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of mitochondrial membrane permeability involved in type I programmed cell death" NARROW [GOC:TermGenie]
synonym: "negative regulation of transport across mitochondrial membrane involved in apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of transport across mitochondrial membrane involved in apoptotic cell death" EXACT [GOC:TermGenie]
synonym: "negative regulation of transport across mitochondrial membrane involved in apoptotic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of transport across mitochondrial membrane involved in apoptotic program" NARROW [GOC:TermGenie]
synonym: "negative regulation of transport across mitochondrial membrane involved in apoptotic programmed cell death" EXACT [GOC:TermGenie]
synonym: "negative regulation of transport across mitochondrial membrane involved in programmed cell death by apoptosis" EXACT [GOC:TermGenie]
synonym: "negative regulation of transport across mitochondrial membrane involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of transport across mitochondrial membrane involved in type I programmed cell death" NARROW [GOC:TermGenie]
is_a: GO:0035795 ! negative regulation of mitochondrial membrane permeability
is_a: GO:1902108 ! regulation of mitochondrial membrane permeability involved in apoptotic process
intersection_of: GO:0035795 ! negative regulation of mitochondrial membrane permeability
intersection_of: part_of GO:0006915 ! apoptotic process
relationship: part_of GO:0006915 ! apoptotic process
created_by: pr
creation_date: 2013-05-03T12:11:53Z

[Term]
id: GO:1902110
name: positive regulation of mitochondrial membrane permeability involved in apoptotic process
namespace: biological_process
def: "Any positive regulation of mitochondrial membrane permeability that is involved in apoptotic process." [GOC:mtg_apoptosis, GOC:pm, GOC:TermGenie, PMID:19168129]
comment: Individual components of the mitochondrial permeability transition pore complex, such as the voltage-dependent anion channel (VDAC), the adenine nucleotide translocase (ANT) and cyclophilin-D (CyP-D), are involved in this process.
synonym: "mitochondrial membrane permeability transition involved in apoptosis" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane permeability transition involved in apoptotic cell death" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane permeability transition involved in apoptotic process" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane permeability transition involved in apoptotic program" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane permeability transition involved in apoptotic programmed cell death" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane permeability transition involved in programmed cell death by apoptosis" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane permeability transition involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie]
synonym: "mitochondrial membrane permeability transition involved in type I programmed cell death" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane permeabilization involved in apoptosis" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane permeabilization involved in apoptotic cell death" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane permeabilization involved in apoptotic process" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane permeabilization involved in apoptotic program" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane permeabilization involved in apoptotic programmed cell death" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane permeabilization involved in programmed cell death by apoptosis" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane permeabilization involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie]
synonym: "mitochondrial membrane permeabilization involved in type I programmed cell death" NARROW [GOC:TermGenie]
synonym: "mitochondrial permeability transition involved in apoptosis" NARROW [GOC:TermGenie]
synonym: "mitochondrial permeability transition involved in apoptotic cell death" NARROW [GOC:TermGenie]
synonym: "mitochondrial permeability transition involved in apoptotic process" NARROW [GOC:TermGenie]
synonym: "mitochondrial permeability transition involved in apoptotic program" NARROW [GOC:TermGenie]
synonym: "mitochondrial permeability transition involved in apoptotic programmed cell death" NARROW [GOC:TermGenie]
synonym: "mitochondrial permeability transition involved in programmed cell death by apoptosis" NARROW [GOC:TermGenie]
synonym: "mitochondrial permeability transition involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie]
synonym: "mitochondrial permeability transition involved in type I programmed cell death" NARROW [GOC:TermGenie]
synonym: "positive regulation of mitochondrial membrane permeability involved in apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of mitochondrial membrane permeability involved in apoptotic cell death" EXACT [GOC:TermGenie]
synonym: "positive regulation of mitochondrial membrane permeability involved in apoptotic program" NARROW [GOC:TermGenie]
synonym: "positive regulation of mitochondrial membrane permeability involved in apoptotic programmed cell death" EXACT [GOC:TermGenie]
synonym: "positive regulation of mitochondrial membrane permeability involved in programmed cell death by apoptosis" EXACT [GOC:TermGenie]
synonym: "positive regulation of mitochondrial membrane permeability involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of mitochondrial membrane permeability involved in type I programmed cell death" NARROW [GOC:TermGenie]
synonym: "positive regulation of transport across mitochondrial membrane involved in apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of transport across mitochondrial membrane involved in apoptotic cell death" EXACT [GOC:TermGenie]
synonym: "positive regulation of transport across mitochondrial membrane involved in apoptotic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of transport across mitochondrial membrane involved in apoptotic program" NARROW [GOC:TermGenie]
synonym: "positive regulation of transport across mitochondrial membrane involved in apoptotic programmed cell death" EXACT [GOC:TermGenie]
synonym: "positive regulation of transport across mitochondrial membrane involved in programmed cell death by apoptosis" EXACT [GOC:TermGenie]
synonym: "positive regulation of transport across mitochondrial membrane involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of transport across mitochondrial membrane involved in type I programmed cell death" NARROW [GOC:TermGenie]
is_a: GO:1902108 ! regulation of mitochondrial membrane permeability involved in apoptotic process
is_a: GO:1902686 ! mitochondrial outer membrane permeabilization involved in programmed cell death
intersection_of: GO:0035794 ! positive regulation of mitochondrial membrane permeability
intersection_of: part_of GO:0006915 ! apoptotic process
relationship: part_of GO:0006915 ! apoptotic process
created_by: pr
creation_date: 2013-05-03T12:13:56Z

[Term]
id: GO:1902111
name: response to diethyl maleate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diethyl maleate stimulus." [GOC:TermGenie, PMID:12100563]
is_a: GO:0010033 ! response to organic substance
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: mah
creation_date: 2013-05-08T16:00:35Z

[Term]
id: GO:1902112
name: cellular response to diethyl maleate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diethyl maleate stimulus." [GOC:TermGenie, PMID:12100563]
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1902111 ! response to diethyl maleate
created_by: mah
creation_date: 2013-05-08T16:00:40Z

[Term]
id: GO:1902113
name: nucleotide phosphorylation involved in DNA repair
namespace: biological_process
def: "Any nucleotide phosphorylation that is involved in DNA repair." [GOC:TermGenie, PMID:11729194]
is_a: GO:0046939 ! nucleotide phosphorylation
intersection_of: GO:0046939 ! nucleotide phosphorylation
intersection_of: part_of GO:0006281 ! DNA repair
relationship: part_of GO:0006281 ! DNA repair
created_by: al
creation_date: 2013-05-13T08:56:02Z

[Term]
id: GO:1902114
name: D-valine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-valine." [GOC:TermGenie, PMID:23085840]
synonym: "D-valine metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006573 ! valine metabolic process
is_a: GO:0046416 ! D-amino acid metabolic process
created_by: al
creation_date: 2013-05-13T23:27:23Z

[Term]
id: GO:1902115
name: regulation of organelle assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of organelle assembly." [GOC:pr, GOC:TermGenie]
is_a: GO:0033043 ! regulation of organelle organization
is_a: GO:0044087 ! regulation of cellular component biogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070925 ! organelle assembly
relationship: regulates GO:0070925 ! organelle assembly
created_by: pr
creation_date: 2013-05-14T09:43:21Z

[Term]
id: GO:1902116
name: negative regulation of organelle assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of organelle assembly." [GOC:pr, GOC:TermGenie]
synonym: "down regulation of organelle assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of organelle assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of organelle assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of organelle assembly" NARROW [GOC:TermGenie]
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:1902115 ! regulation of organelle assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070925 ! organelle assembly
relationship: negatively_regulates GO:0070925 ! organelle assembly
created_by: pr
creation_date: 2013-05-14T09:43:31Z

[Term]
id: GO:1902117
name: positive regulation of organelle assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of organelle assembly." [GOC:pr, GOC:TermGenie]
synonym: "activation of organelle assembly" NARROW [GOC:TermGenie]
synonym: "up regulation of organelle assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of organelle assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of organelle assembly" EXACT [GOC:TermGenie]
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:1902115 ! regulation of organelle assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070925 ! organelle assembly
relationship: positively_regulates GO:0070925 ! organelle assembly
created_by: pr
creation_date: 2013-05-14T09:43:36Z

[Term]
id: GO:1902118
name: calcidiol binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with calcidiol." [GOC:bf, GOC:TermGenie, PMID:11799400]
synonym: "25(OH)D3 binding" EXACT [CHEBI:17933]
synonym: "25-hydroxycholecalciferol binding" EXACT [CHEBI:17933]
synonym: "25-hydroxyvitamin D3 binding" EXACT [CHEBI:17933]
synonym: "25OHD3 binding" EXACT [PMID:11799400]
synonym: "calcifediol binding" EXACT [CHEBI:17933]
is_a: GO:1902271 ! D3 vitamins binding
created_by: bf
creation_date: 2013-05-15T14:55:58Z

[Term]
id: GO:1902119
name: regulation of meiotic spindle elongation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of meiotic spindle elongation." [GOC:TermGenie, PMID:23370392]
synonym: "regulation of spindle elongation during meiosis" EXACT [GOC:TermGenie]
is_a: GO:0032887 ! regulation of spindle elongation
is_a: GO:0040020 ! regulation of meiotic nuclear division
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051232 ! meiotic spindle elongation
relationship: regulates GO:0051232 ! meiotic spindle elongation
created_by: al
creation_date: 2013-05-15T15:15:48Z

[Term]
id: GO:1902120
name: negative regulation of meiotic spindle elongation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of meiotic spindle elongation." [GOC:TermGenie, PMID:23370392]
synonym: "down regulation of meiotic spindle elongation" EXACT [GOC:TermGenie]
synonym: "down regulation of spindle elongation during meiosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of meiotic spindle elongation" EXACT [GOC:TermGenie]
synonym: "down-regulation of spindle elongation during meiosis" EXACT [GOC:TermGenie]
synonym: "downregulation of meiotic spindle elongation" EXACT [GOC:TermGenie]
synonym: "downregulation of spindle elongation during meiosis" EXACT [GOC:TermGenie]
synonym: "inhibition of meiotic spindle elongation" NARROW [GOC:TermGenie]
synonym: "inhibition of spindle elongation during meiosis" EXACT [GOC:TermGenie]
synonym: "negative regulation of spindle elongation during meiosis" EXACT [GOC:TermGenie]
is_a: GO:0031117 ! positive regulation of microtubule depolymerization
is_a: GO:0045835 ! negative regulation of meiotic nuclear division
is_a: GO:0051494 ! negative regulation of cytoskeleton organization
is_a: GO:0051985 ! negative regulation of chromosome segregation
is_a: GO:1902119 ! regulation of meiotic spindle elongation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051232 ! meiotic spindle elongation
relationship: negatively_regulates GO:0051232 ! meiotic spindle elongation
created_by: al
creation_date: 2013-05-15T15:15:53Z

[Term]
id: GO:1902121
name: lithocholic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with lithocholic acid." [GOC:bf, GOC:TermGenie, PMID:20371703]
synonym: "LCA binding" EXACT [PMID:20371703]
is_a: GO:0032052 ! bile acid binding
created_by: bf
creation_date: 2013-05-15T16:05:12Z

[Term]
id: GO:1902122
name: chenodeoxycholic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with chenodeoxycholic acid." [GOC:bf, GOC:TermGenie, PMID:10334992]
synonym: "CDCA binding" EXACT [CHEBI:16755]
is_a: GO:0032052 ! bile acid binding
created_by: bf
creation_date: 2013-05-16T09:17:19Z

[Term]
id: GO:1902123
name: (-)-pinoresinol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of (-)-pinoresinol." [GOC:TermGenie, PubMed:15949826, PubMed:9872995]
synonym: "(-)-pinoresinol breakdown" EXACT [GOC:TermGenie]
synonym: "(-)-pinoresinol catabolism" EXACT [GOC:TermGenie]
synonym: "(-)-pinoresinol degradation" EXACT [GOC:TermGenie]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0046273 ! lignan catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1901598 ! (-)-pinoresinol metabolic process
created_by: ms
creation_date: 2013-05-21T08:49:05Z

[Term]
id: GO:1902124
name: (+)-pinoresinol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (+)-pinoresinol." [GOC:TermGenie, PubMed:8910615, PubMed:9872995]
synonym: "(+)-pinoresinol metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009806 ! lignan metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
created_by: ms
creation_date: 2013-05-21T08:49:10Z

[Term]
id: GO:1902125
name: (+)-pinoresinol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of (+)-pinoresinol." [GOC:TermGenie, PubMed:8910615, PubMed:9872995]
synonym: "(+)-pinoresinol breakdown" EXACT [GOC:TermGenie]
synonym: "(+)-pinoresinol catabolism" EXACT [GOC:TermGenie]
synonym: "(+)-pinoresinol degradation" EXACT [GOC:TermGenie]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0046273 ! lignan catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1902124 ! (+)-pinoresinol metabolic process
created_by: ms
creation_date: 2013-05-21T08:49:23Z

[Term]
id: GO:1902126
name: (+)-pinoresinol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (+)-pinoresinol." [GOC:TermGenie, PubMed:8910615, PubMed:9872995]
synonym: "(+)-pinoresinol anabolism" EXACT [GOC:TermGenie]
synonym: "(+)-pinoresinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "(+)-pinoresinol formation" EXACT [GOC:TermGenie]
synonym: "(+)-pinoresinol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009807 ! lignan biosynthetic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:1902124 ! (+)-pinoresinol metabolic process
created_by: ms
creation_date: 2013-05-21T08:49:28Z

[Term]
id: GO:1902127
name: (-)-lariciresinol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (-)-lariciresinol." [GOC:TermGenie, PubMed:15949826, PubMed:9872995]
synonym: "(-)-lariciresinol metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009806 ! lignan metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
created_by: ms
creation_date: 2013-05-21T08:49:33Z

[Term]
id: GO:1902128
name: (-)-lariciresinol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of (-)-lariciresinol." [GOC:TermGenie, PubMed:15949826, PubMed:9872995]
synonym: "(-)-lariciresinol breakdown" EXACT [GOC:TermGenie]
synonym: "(-)-lariciresinol catabolism" EXACT [GOC:TermGenie]
synonym: "(-)-lariciresinol degradation" EXACT [GOC:TermGenie]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0046273 ! lignan catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1902127 ! (-)-lariciresinol metabolic process
created_by: ms
creation_date: 2013-05-21T08:49:38Z

[Term]
id: GO:1902129
name: (-)-lariciresinol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (-)-lariciresinol." [GOC:TermGenie, PubMed:15949826, PubMed:9872995]
synonym: "(-)-lariciresinol anabolism" EXACT [GOC:TermGenie]
synonym: "(-)-lariciresinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "(-)-lariciresinol formation" EXACT [GOC:TermGenie]
synonym: "(-)-lariciresinol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009807 ! lignan biosynthetic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:1902127 ! (-)-lariciresinol metabolic process
created_by: ms
creation_date: 2013-05-21T08:49:44Z

[Term]
id: GO:1902130
name: (+)-lariciresinol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (+)-lariciresinol." [GOC:TermGenie, PubMed:8910615, PubMed:9872995]
synonym: "(+)-lariciresinol metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009806 ! lignan metabolic process
is_a: GO:0018904 ! ether metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0034308 ! primary alcohol metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
created_by: ms
creation_date: 2013-05-21T08:49:49Z

[Term]
id: GO:1902131
name: (+)-lariciresinol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of (+)-lariciresinol." [GOC:TermGenie, PubMed:8910615, PubMed:9872995]
synonym: "(+)-lariciresinol breakdown" EXACT [GOC:TermGenie]
synonym: "(+)-lariciresinol catabolism" EXACT [GOC:TermGenie]
synonym: "(+)-lariciresinol degradation" EXACT [GOC:TermGenie]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0034310 ! primary alcohol catabolic process
is_a: GO:0046273 ! lignan catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1901502 ! ether catabolic process
is_a: GO:1902130 ! (+)-lariciresinol metabolic process
created_by: ms
creation_date: 2013-05-21T08:49:54Z

[Term]
id: GO:1902132
name: (+)-lariciresinol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (+)-lariciresinol." [GOC:TermGenie, PubMed:8910615, PubMed:9872995]
synonym: "(+)-lariciresinol anabolism" EXACT [GOC:TermGenie]
synonym: "(+)-lariciresinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "(+)-lariciresinol formation" EXACT [GOC:TermGenie]
synonym: "(+)-lariciresinol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009807 ! lignan biosynthetic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0034309 ! primary alcohol biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:1901503 ! ether biosynthetic process
is_a: GO:1902130 ! (+)-lariciresinol metabolic process
created_by: ms
creation_date: 2013-05-21T08:49:59Z

[Term]
id: GO:1902133
name: (+)-secoisolariciresinol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (+)-secoisolariciresinol." [GOC:TermGenie, PubMed:15949826, PubMed:9872995]
synonym: "(+)-secoisolariciresinol metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009806 ! lignan metabolic process
is_a: GO:0034311 ! diol metabolic process
created_by: ms
creation_date: 2013-05-21T08:50:04Z

[Term]
id: GO:1902134
name: (+)-secoisolariciresinol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of (+)-secoisolariciresinol." [GOC:TermGenie, PubMed:15949826, PubMed:9872995]
synonym: "(+)-secoisolariciresinol breakdown" EXACT [GOC:TermGenie]
synonym: "(+)-secoisolariciresinol catabolism" EXACT [GOC:TermGenie]
synonym: "(+)-secoisolariciresinol degradation" EXACT [GOC:TermGenie]
is_a: GO:0034313 ! diol catabolic process
is_a: GO:0046273 ! lignan catabolic process
is_a: GO:1902133 ! (+)-secoisolariciresinol metabolic process
created_by: ms
creation_date: 2013-05-21T08:50:09Z

[Term]
id: GO:1902135
name: (+)-secoisolariciresinol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (+)-secoisolariciresinol." [GOC:TermGenie, PubMed:15949826, PubMed:9872995]
synonym: "(+)-secoisolariciresinol anabolism" EXACT [GOC:TermGenie]
synonym: "(+)-secoisolariciresinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "(+)-secoisolariciresinol formation" EXACT [GOC:TermGenie]
synonym: "(+)-secoisolariciresinol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009807 ! lignan biosynthetic process
is_a: GO:0034312 ! diol biosynthetic process
is_a: GO:1902133 ! (+)-secoisolariciresinol metabolic process
created_by: ms
creation_date: 2013-05-21T08:50:14Z

[Term]
id: GO:1902136
name: (-)-secoisolariciresinol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (-)-secoisolariciresinol." [GOC:TermGenie, PubMed:8910615, PubMed:9872995]
synonym: "(-)-secoisolariciresinol metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009806 ! lignan metabolic process
is_a: GO:0034311 ! diol metabolic process
created_by: ms
creation_date: 2013-05-21T08:50:19Z

[Term]
id: GO:1902137
name: (-)-secoisolariciresinol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of (-)-secoisolariciresinol." [GOC:TermGenie, PubMed:8910615, PubMed:9872995]
synonym: "(-)-secoisolariciresinol breakdown" EXACT [GOC:TermGenie]
synonym: "(-)-secoisolariciresinol catabolism" EXACT [GOC:TermGenie]
synonym: "(-)-secoisolariciresinol degradation" EXACT [GOC:TermGenie]
is_a: GO:0034313 ! diol catabolic process
is_a: GO:0046273 ! lignan catabolic process
is_a: GO:1902136 ! (-)-secoisolariciresinol metabolic process
created_by: ms
creation_date: 2013-05-21T08:50:24Z

[Term]
id: GO:1902138
name: (-)-secoisolariciresinol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (-)-secoisolariciresinol." [GOC:TermGenie, PubMed:8910615, PubMed:9872995]
synonym: "(-)-secoisolariciresinol anabolism" EXACT [GOC:TermGenie]
synonym: "(-)-secoisolariciresinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "(-)-secoisolariciresinol formation" EXACT [GOC:TermGenie]
synonym: "(-)-secoisolariciresinol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009807 ! lignan biosynthetic process
is_a: GO:0034312 ! diol biosynthetic process
is_a: GO:1902136 ! (-)-secoisolariciresinol metabolic process
created_by: ms
creation_date: 2013-05-21T08:50:29Z

[Term]
id: GO:1902140
name: response to inositol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inositol stimulus." [GOC:TermGenie, PMID:16496115]
is_a: GO:0010033 ! response to organic substance
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: al
creation_date: 2013-05-21T13:42:10Z

[Term]
id: GO:1902141
name: cellular response to inositol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inositol stimulus." [GOC:TermGenie, PMID:16496115]
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1902140 ! response to inositol
created_by: al
creation_date: 2013-05-21T13:42:15Z

[Term]
id: GO:1902145
name: regulation of response to cell cycle checkpoint signaling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to cell cycle checkpoint signaling." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "regulation of cell cycle checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "regulation of G1/S transition checkpoint effector process" RELATED [GOC:TermGenie]
synonym: "regulation of G2/M transition checkpoint effector process" RELATED [GOC:TermGenie]
synonym: "regulation of response to G1/S transition checkpoint signaling" RELATED [GOC:TermGenie]
synonym: "regulation of response to G2/M transition checkpoint signaling" RELATED [GOC:TermGenie]
synonym: "regulation of response to signal involved in cell cycle checkpoint" EXACT [GOC:TermGenie]
synonym: "regulation of response to signal involved in G1/S transition checkpoint" RELATED [GOC:TermGenie]
synonym: "regulation of response to signal involved in G2/M transition checkpoint" RELATED [GOC:TermGenie]
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072396 ! response to cell cycle checkpoint signaling
relationship: regulates GO:0072396 ! response to cell cycle checkpoint signaling
created_by: jl
creation_date: 2013-05-21T15:43:40Z

[Term]
id: GO:1902146
name: positive regulation of response to cell cycle checkpoint signaling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to cell cycle checkpoint signaling." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "activation of cell cycle checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "activation of G1/S transition checkpoint effector process" RELATED [GOC:TermGenie]
synonym: "activation of G2/M transition checkpoint effector process" RELATED [GOC:TermGenie]
synonym: "activation of response to cell cycle checkpoint signaling" NARROW [GOC:TermGenie]
synonym: "activation of response to G1/S transition checkpoint signaling" RELATED [GOC:TermGenie]
synonym: "activation of response to G2/M transition checkpoint signaling" RELATED [GOC:TermGenie]
synonym: "activation of response to signal involved in cell cycle checkpoint" EXACT [GOC:TermGenie]
synonym: "activation of response to signal involved in G1/S transition checkpoint" RELATED [GOC:TermGenie]
synonym: "activation of response to signal involved in G2/M transition checkpoint" RELATED [GOC:TermGenie]
synonym: "positive regulation of cell cycle checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "positive regulation of G1/S transition checkpoint effector process" RELATED [GOC:TermGenie]
synonym: "positive regulation of G2/M transition checkpoint effector process" RELATED [GOC:TermGenie]
synonym: "positive regulation of response to G1/S transition checkpoint signaling" RELATED [GOC:TermGenie]
synonym: "positive regulation of response to G2/M transition checkpoint signaling" RELATED [GOC:TermGenie]
synonym: "positive regulation of response to signal involved in cell cycle checkpoint" EXACT [GOC:TermGenie]
synonym: "positive regulation of response to signal involved in G1/S transition checkpoint" RELATED [GOC:TermGenie]
synonym: "positive regulation of response to signal involved in G2/M transition checkpoint" RELATED [GOC:TermGenie]
synonym: "up regulation of cell cycle checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "up regulation of G1/S transition checkpoint effector process" RELATED [GOC:TermGenie]
synonym: "up regulation of G2/M transition checkpoint effector process" RELATED [GOC:TermGenie]
synonym: "up regulation of response to cell cycle checkpoint signaling" EXACT [GOC:TermGenie]
synonym: "up regulation of response to G1/S transition checkpoint signaling" RELATED [GOC:TermGenie]
synonym: "up regulation of response to G2/M transition checkpoint signaling" RELATED [GOC:TermGenie]
synonym: "up regulation of response to signal involved in cell cycle checkpoint" EXACT [GOC:TermGenie]
synonym: "up regulation of response to signal involved in G1/S transition checkpoint" RELATED [GOC:TermGenie]
synonym: "up regulation of response to signal involved in G2/M transition checkpoint" RELATED [GOC:TermGenie]
synonym: "up-regulation of cell cycle checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "up-regulation of G1/S transition checkpoint effector process" RELATED [GOC:TermGenie]
synonym: "up-regulation of G2/M transition checkpoint effector process" RELATED [GOC:TermGenie]
synonym: "up-regulation of response to cell cycle checkpoint signaling" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to G1/S transition checkpoint signaling" RELATED [GOC:TermGenie]
synonym: "up-regulation of response to G2/M transition checkpoint signaling" RELATED [GOC:TermGenie]
synonym: "up-regulation of response to signal involved in cell cycle checkpoint" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to signal involved in G1/S transition checkpoint" RELATED [GOC:TermGenie]
synonym: "up-regulation of response to signal involved in G2/M transition checkpoint" RELATED [GOC:TermGenie]
synonym: "upregulation of cell cycle checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "upregulation of G1/S transition checkpoint effector process" RELATED [GOC:TermGenie]
synonym: "upregulation of G2/M transition checkpoint effector process" RELATED [GOC:TermGenie]
synonym: "upregulation of response to cell cycle checkpoint signaling" EXACT [GOC:TermGenie]
synonym: "upregulation of response to G1/S transition checkpoint signaling" RELATED [GOC:TermGenie]
synonym: "upregulation of response to G2/M transition checkpoint signaling" RELATED [GOC:TermGenie]
synonym: "upregulation of response to signal involved in cell cycle checkpoint" EXACT [GOC:TermGenie]
synonym: "upregulation of response to signal involved in G1/S transition checkpoint" RELATED [GOC:TermGenie]
synonym: "upregulation of response to signal involved in G2/M transition checkpoint" RELATED [GOC:TermGenie]
is_a: GO:0002833 ! positive regulation of response to biotic stimulus
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:1902145 ! regulation of response to cell cycle checkpoint signaling
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072396 ! response to cell cycle checkpoint signaling
relationship: positively_regulates GO:0072396 ! response to cell cycle checkpoint signaling
created_by: jl
creation_date: 2013-05-21T15:43:45Z

[Term]
id: GO:1902147
name: regulation of response to cytokinesis checkpoint signaling
namespace: biological_process
alt_id: GO:1902149
def: "Any process that modulates the frequency, rate or extent of response to cytokinesis checkpoint signaling." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "regulation of cytokinesis checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "regulation of response to septin checkpoint signaling" EXACT []
synonym: "regulation of response to signal involved in cytokinesis checkpoint" EXACT [GOC:TermGenie]
synonym: "regulation of response to signal involved in septin checkpoint" EXACT [GOC:TermGenie]
synonym: "regulation of septin checkpoint effector process" EXACT [GOC:TermGenie]
is_a: GO:1902145 ! regulation of response to cell cycle checkpoint signaling
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072399 ! response to cytokinesis checkpoint signaling
relationship: regulates GO:0072399 ! response to cytokinesis checkpoint signaling
created_by: jl
creation_date: 2013-05-21T15:43:53Z

[Term]
id: GO:1902148
name: positive regulation of response to cytokinesis checkpoint signaling
namespace: biological_process
alt_id: GO:1902150
def: "Any process that activates or increases the frequency, rate or extent of response to cytokinesis checkpoint signaling." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "activation of cytokinesis checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "activation of response to cytokinesis checkpoint signaling" NARROW [GOC:TermGenie]
synonym: "activation of response to septin checkpoint signaling" NARROW [GOC:TermGenie]
synonym: "activation of response to signal involved in cytokinesis checkpoint" EXACT [GOC:TermGenie]
synonym: "activation of response to signal involved in septin checkpoint" EXACT [GOC:TermGenie]
synonym: "activation of septin checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "positive regulation of cytokinesis checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "positive regulation of response to septin checkpoint signaling" EXACT []
synonym: "positive regulation of response to signal involved in cytokinesis checkpoint" EXACT [GOC:TermGenie]
synonym: "positive regulation of response to signal involved in septin checkpoint" EXACT [GOC:TermGenie]
synonym: "positive regulation of septin checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "up regulation of cytokinesis checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "up regulation of response to cytokinesis checkpoint signaling" EXACT [GOC:TermGenie]
synonym: "up regulation of response to septin checkpoint signaling" EXACT [GOC:TermGenie]
synonym: "up regulation of response to signal involved in cytokinesis checkpoint" EXACT [GOC:TermGenie]
synonym: "up regulation of response to signal involved in septin checkpoint" EXACT [GOC:TermGenie]
synonym: "up regulation of septin checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "up-regulation of cytokinesis checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to cytokinesis checkpoint signaling" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to septin checkpoint signaling" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to signal involved in cytokinesis checkpoint" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to signal involved in septin checkpoint" EXACT [GOC:TermGenie]
synonym: "up-regulation of septin checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "upregulation of cytokinesis checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "upregulation of response to cytokinesis checkpoint signaling" EXACT [GOC:TermGenie]
synonym: "upregulation of response to septin checkpoint signaling" EXACT [GOC:TermGenie]
synonym: "upregulation of response to signal involved in cytokinesis checkpoint" EXACT [GOC:TermGenie]
synonym: "upregulation of response to signal involved in septin checkpoint" EXACT [GOC:TermGenie]
synonym: "upregulation of septin checkpoint effector process" EXACT [GOC:TermGenie]
is_a: GO:1902146 ! positive regulation of response to cell cycle checkpoint signaling
is_a: GO:1902147 ! regulation of response to cytokinesis checkpoint signaling
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072399 ! response to cytokinesis checkpoint signaling
relationship: positively_regulates GO:0072399 ! response to cytokinesis checkpoint signaling
created_by: jl
creation_date: 2013-05-21T15:43:58Z

[Term]
id: GO:1902151
name: regulation of response to DNA integrity checkpoint signaling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to DNA integrity checkpoint signaling." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "regulation of DNA integrity checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "regulation of response to signal involved in DNA integrity checkpoint" EXACT [GOC:TermGenie]
is_a: GO:1902145 ! regulation of response to cell cycle checkpoint signaling
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072402 ! response to DNA integrity checkpoint signaling
relationship: regulates GO:0072402 ! response to DNA integrity checkpoint signaling
created_by: jl
creation_date: 2013-05-21T15:44:26Z

[Term]
id: GO:1902152
name: positive regulation of response to DNA integrity checkpoint signaling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to DNA integrity checkpoint signaling." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "activation of DNA integrity checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "activation of response to DNA integrity checkpoint signaling" NARROW [GOC:TermGenie]
synonym: "activation of response to signal involved in DNA integrity checkpoint" EXACT [GOC:TermGenie]
synonym: "positive regulation of DNA integrity checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "positive regulation of response to signal involved in DNA integrity checkpoint" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA integrity checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "up regulation of response to DNA integrity checkpoint signaling" EXACT [GOC:TermGenie]
synonym: "up regulation of response to signal involved in DNA integrity checkpoint" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA integrity checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to DNA integrity checkpoint signaling" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to signal involved in DNA integrity checkpoint" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA integrity checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "upregulation of response to DNA integrity checkpoint signaling" EXACT [GOC:TermGenie]
synonym: "upregulation of response to signal involved in DNA integrity checkpoint" EXACT [GOC:TermGenie]
is_a: GO:1902146 ! positive regulation of response to cell cycle checkpoint signaling
is_a: GO:1902151 ! regulation of response to DNA integrity checkpoint signaling
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072402 ! response to DNA integrity checkpoint signaling
relationship: positively_regulates GO:0072402 ! response to DNA integrity checkpoint signaling
created_by: jl
creation_date: 2013-05-21T15:44:31Z

[Term]
id: GO:1902153
name: regulation of response to DNA damage checkpoint signaling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to DNA damage checkpoint signaling." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "regulation of DNA damage checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "regulation of response to signal involved in DNA damage checkpoint" EXACT [GOC:TermGenie]
is_a: GO:1902151 ! regulation of response to DNA integrity checkpoint signaling
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072423 ! response to DNA damage checkpoint signaling
relationship: regulates GO:0072423 ! response to DNA damage checkpoint signaling
created_by: jl
creation_date: 2013-05-21T15:44:39Z

[Term]
id: GO:1902154
name: positive regulation of response to DNA damage checkpoint signaling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to DNA damage checkpoint signaling." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "activation of DNA damage checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "activation of response to DNA damage checkpoint signaling" NARROW [GOC:TermGenie]
synonym: "activation of response to signal involved in DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "positive regulation of DNA damage checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "positive regulation of response to signal involved in DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA damage checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "up regulation of response to DNA damage checkpoint signaling" EXACT [GOC:TermGenie]
synonym: "up regulation of response to signal involved in DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA damage checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to DNA damage checkpoint signaling" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to signal involved in DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA damage checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "upregulation of response to DNA damage checkpoint signaling" EXACT [GOC:TermGenie]
synonym: "upregulation of response to signal involved in DNA damage checkpoint" EXACT [GOC:TermGenie]
is_a: GO:1902152 ! positive regulation of response to DNA integrity checkpoint signaling
is_a: GO:1902153 ! regulation of response to DNA damage checkpoint signaling
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072423 ! response to DNA damage checkpoint signaling
relationship: positively_regulates GO:0072423 ! response to DNA damage checkpoint signaling
created_by: jl
creation_date: 2013-05-21T15:44:44Z

[Term]
id: GO:1902155
name: regulation of response to G1 DNA damage checkpoint signaling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to G1 DNA damage checkpoint signaling." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "regulation of mitotic cell cycle G1/S transition DNA damage checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "regulation of response to mitotic cell cycle G1/S transition DNA damage checkpoint signaling" EXACT [GOC:TermGenie]
synonym: "regulation of response to signal involved in mitotic cell cycle G1/S transition DNA damage checkpoint" EXACT [GOC:TermGenie]
is_a: GO:1902153 ! regulation of response to DNA damage checkpoint signaling
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072432 ! response to G1 DNA damage checkpoint signaling
relationship: regulates GO:0072432 ! response to G1 DNA damage checkpoint signaling
created_by: jl
creation_date: 2013-05-21T15:44:53Z

[Term]
id: GO:1902156
name: positive regulation of response to G1 DNA damage checkpoint signaling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to G1 DNA damage checkpoint signaling." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "activation of mitotic cell cycle G1/S transition DNA damage checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "activation of response to G1 DNA damage checkpoint signaling" NARROW [GOC:TermGenie]
synonym: "activation of response to mitotic cell cycle G1/S transition DNA damage checkpoint signaling" EXACT [GOC:TermGenie]
synonym: "activation of response to signal involved in mitotic cell cycle G1/S transition DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "positive regulation of mitotic cell cycle G1/S transition DNA damage checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "positive regulation of response to mitotic cell cycle G1/S transition DNA damage checkpoint signaling" EXACT [GOC:TermGenie]
synonym: "positive regulation of response to signal involved in mitotic cell cycle G1/S transition DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "up regulation of mitotic cell cycle G1/S transition DNA damage checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "up regulation of response to G1 DNA damage checkpoint signaling" EXACT [GOC:TermGenie]
synonym: "up regulation of response to mitotic cell cycle G1/S transition DNA damage checkpoint signaling" EXACT [GOC:TermGenie]
synonym: "up regulation of response to signal involved in mitotic cell cycle G1/S transition DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitotic cell cycle G1/S transition DNA damage checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to G1 DNA damage checkpoint signaling" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to mitotic cell cycle G1/S transition DNA damage checkpoint signaling" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to signal involved in mitotic cell cycle G1/S transition DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "upregulation of mitotic cell cycle G1/S transition DNA damage checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "upregulation of response to G1 DNA damage checkpoint signaling" EXACT [GOC:TermGenie]
synonym: "upregulation of response to mitotic cell cycle G1/S transition DNA damage checkpoint signaling" EXACT [GOC:TermGenie]
synonym: "upregulation of response to signal involved in mitotic cell cycle G1/S transition DNA damage checkpoint" EXACT [GOC:TermGenie]
is_a: GO:1902154 ! positive regulation of response to DNA damage checkpoint signaling
is_a: GO:1902155 ! regulation of response to G1 DNA damage checkpoint signaling
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072432 ! response to G1 DNA damage checkpoint signaling
relationship: positively_regulates GO:0072432 ! response to G1 DNA damage checkpoint signaling
created_by: jl
creation_date: 2013-05-21T15:44:58Z

[Term]
id: GO:1902157
name: regulation of response to G2 DNA damage checkpoint signaling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to G2 DNA damage checkpoint signaling." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "regulation of G2/M transition DNA damage checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "regulation of response to signal involved in G2/M transition DNA damage checkpoint" EXACT [GOC:TermGenie]
is_a: GO:1902153 ! regulation of response to DNA damage checkpoint signaling
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072426 ! response to G2 DNA damage checkpoint signaling
relationship: regulates GO:0072426 ! response to G2 DNA damage checkpoint signaling
created_by: jl
creation_date: 2013-05-21T15:45:06Z

[Term]
id: GO:1902158
name: positive regulation of response to G2 DNA damage checkpoint signaling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to G2 DNA damage checkpoint signaling." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "activation of G2/M transition DNA damage checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "activation of response to G2 DNA damage checkpoint signaling" NARROW [GOC:TermGenie]
synonym: "activation of response to signal involved in G2/M transition DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "positive regulation of G2/M transition DNA damage checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "positive regulation of response to signal involved in G2/M transition DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "up regulation of G2/M transition DNA damage checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "up regulation of response to G2 DNA damage checkpoint signaling" EXACT [GOC:TermGenie]
synonym: "up regulation of response to signal involved in G2/M transition DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "up-regulation of G2/M transition DNA damage checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to G2 DNA damage checkpoint signaling" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to signal involved in G2/M transition DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "upregulation of G2/M transition DNA damage checkpoint effector process" EXACT [GOC:TermGenie]
synonym: "upregulation of response to G2 DNA damage checkpoint signaling" EXACT [GOC:TermGenie]
synonym: "upregulation of response to signal involved in G2/M transition DNA damage checkpoint" EXACT [GOC:TermGenie]
is_a: GO:1902154 ! positive regulation of response to DNA damage checkpoint signaling
is_a: GO:1902157 ! regulation of response to G2 DNA damage checkpoint signaling
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072426 ! response to G2 DNA damage checkpoint signaling
relationship: positively_regulates GO:0072426 ! response to G2 DNA damage checkpoint signaling
created_by: jl
creation_date: 2013-05-21T15:45:10Z

[Term]
id: GO:1902159
name: regulation of cyclic nucleotide-gated ion channel activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cyclic nucleotide-gated ion channel activity." [GOC:TermGenie, PMID:11420311]
synonym: "regulation of cyclic nucleotide activated ion channel activity" EXACT [GOC:TermGenie]
synonym: "regulation of cyclic nucleotide gated ion channel activity" EXACT [GOC:TermGenie]
synonym: "regulation of cyclic nucleotide-activated ion channel activity" EXACT [GOC:TermGenie]
is_a: GO:0010469 ! regulation of receptor activity
is_a: GO:0032412 ! regulation of ion transmembrane transporter activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043855 ! cyclic nucleotide-gated ion channel activity
relationship: regulates GO:0043855 ! cyclic nucleotide-gated ion channel activity
created_by: sl
creation_date: 2013-05-21T19:24:30Z

[Term]
id: GO:1902160
name: negative regulation of cyclic nucleotide-gated ion channel activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cyclic nucleotide-gated ion channel activity." [GOC:TermGenie, PMID:11420311]
synonym: "down regulation of cyclic nucleotide activated ion channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of cyclic nucleotide gated ion channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of cyclic nucleotide-activated ion channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of cyclic nucleotide-gated ion channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of cyclic nucleotide activated ion channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of cyclic nucleotide gated ion channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of cyclic nucleotide-activated ion channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of cyclic nucleotide-gated ion channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of cyclic nucleotide activated ion channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of cyclic nucleotide gated ion channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of cyclic nucleotide-activated ion channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of cyclic nucleotide-gated ion channel activity" EXACT [GOC:TermGenie]
synonym: "inhibition of cyclic nucleotide activated ion channel activity" EXACT [GOC:TermGenie]
synonym: "inhibition of cyclic nucleotide gated ion channel activity" EXACT [GOC:TermGenie]
synonym: "inhibition of cyclic nucleotide-activated ion channel activity" EXACT [GOC:TermGenie]
synonym: "inhibition of cyclic nucleotide-gated ion channel activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of cyclic nucleotide activated ion channel activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of cyclic nucleotide gated ion channel activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of cyclic nucleotide-activated ion channel activity" EXACT [GOC:TermGenie]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity
is_a: GO:1902159 ! regulation of cyclic nucleotide-gated ion channel activity
is_a: GO:2000272 ! negative regulation of receptor activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043855 ! cyclic nucleotide-gated ion channel activity
relationship: negatively_regulates GO:0043855 ! cyclic nucleotide-gated ion channel activity
created_by: sl
creation_date: 2013-05-21T19:24:35Z

[Term]
id: GO:1902161
name: positive regulation of cyclic nucleotide-gated ion channel activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cyclic nucleotide-gated ion channel activity." [GOC:TermGenie, PMID:11420311]
synonym: "activation of cyclic nucleotide activated ion channel activity" EXACT [GOC:TermGenie]
synonym: "activation of cyclic nucleotide gated ion channel activity" EXACT [GOC:TermGenie]
synonym: "activation of cyclic nucleotide-activated ion channel activity" EXACT [GOC:TermGenie]
synonym: "activation of cyclic nucleotide-gated ion channel activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of cyclic nucleotide activated ion channel activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of cyclic nucleotide gated ion channel activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of cyclic nucleotide-activated ion channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of cyclic nucleotide activated ion channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of cyclic nucleotide gated ion channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of cyclic nucleotide-activated ion channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of cyclic nucleotide-gated ion channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of cyclic nucleotide activated ion channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of cyclic nucleotide gated ion channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of cyclic nucleotide-activated ion channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of cyclic nucleotide-gated ion channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of cyclic nucleotide activated ion channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of cyclic nucleotide gated ion channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of cyclic nucleotide-activated ion channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of cyclic nucleotide-gated ion channel activity" EXACT [GOC:TermGenie]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity
is_a: GO:1902159 ! regulation of cyclic nucleotide-gated ion channel activity
is_a: GO:2000273 ! positive regulation of receptor activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043855 ! cyclic nucleotide-gated ion channel activity
relationship: positively_regulates GO:0043855 ! cyclic nucleotide-gated ion channel activity
created_by: sl
creation_date: 2013-05-21T19:24:48Z

[Term]
id: GO:1902162
name: regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator." [GOC:TermGenie, pubmed:17719541]
is_a: GO:0043516 ! regulation of DNA damage response, signal transduction by p53 class mediator
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006978 ! DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
relationship: regulates GO:0006978 ! DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
created_by: lb
creation_date: 2013-05-22T12:39:18Z

[Term]
id: GO:1902163
name: negative regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator." [GOC:TermGenie, pubmed:17719541]
synonym: "down regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator" EXACT [GOC:TermGenie]
synonym: "inhibition of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator" NARROW [GOC:TermGenie]
is_a: GO:0043518 ! negative regulation of DNA damage response, signal transduction by p53 class mediator
is_a: GO:1902162 ! regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006978 ! DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
relationship: negatively_regulates GO:0006978 ! DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
created_by: lb
creation_date: 2013-05-22T12:39:23Z

[Term]
id: GO:1902164
name: positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator." [GOC:TermGenie, pubmed:17719541]
synonym: "activation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator" NARROW [GOC:TermGenie]
synonym: "up regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator" EXACT [GOC:TermGenie]
is_a: GO:0043517 ! positive regulation of DNA damage response, signal transduction by p53 class mediator
is_a: GO:1902162 ! regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006978 ! DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
relationship: positively_regulates GO:0006978 ! DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
created_by: lb
creation_date: 2013-05-22T12:39:29Z

[Term]
id: GO:1902165
name: regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator." [GOC:TermGenie, PMID:17719541]
synonym: "regulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie]
is_a: GO:1902229 ! regulation of intrinsic apoptotic signaling pathway in response to DNA damage
is_a: GO:1902253 ! regulation of intrinsic apoptotic signaling pathway by p53 class mediator
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042771 ! intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
relationship: regulates GO:0042771 ! intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
created_by: lb
creation_date: 2013-05-22T12:45:10Z

[Term]
id: GO:1902166
name: negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator." [GOC:TermGenie, PMID:17719541]
synonym: "down regulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie]
synonym: "down regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie]
synonym: "down-regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie]
synonym: "downregulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "inhibition of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie]
synonym: "inhibition of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator" NARROW [GOC:TermGenie]
synonym: "negative regulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie]
is_a: GO:1902165 ! regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
is_a: GO:1902230 ! negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
is_a: GO:1902254 ! negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042771 ! intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
relationship: negatively_regulates GO:0042771 ! intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
created_by: lb
creation_date: 2013-05-22T12:45:15Z

[Term]
id: GO:1902167
name: positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator." [GOC:TermGenie, PMID:17719541]
synonym: "activation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie]
synonym: "activation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator" NARROW [GOC:TermGenie]
synonym: "positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie]
synonym: "up regulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie]
synonym: "up regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie]
synonym: "up-regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie]
synonym: "upregulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator" EXACT [GOC:TermGenie]
is_a: GO:1902165 ! regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
is_a: GO:1902231 ! positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
is_a: GO:1902255 ! positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042771 ! intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
relationship: positively_regulates GO:0042771 ! intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
created_by: lb
creation_date: 2013-05-22T12:45:20Z

[Term]
id: GO:1902168
name: response to catechin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catechin stimulus." [GOC:rjd, GOC:TermGenie, PMID:23516620]
is_a: GO:0080184 ! response to phenylpropanoid
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: rjd
creation_date: 2013-05-22T17:35:35Z

[Term]
id: GO:1902169
name: cellular response to catechin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catechin stimulus." [GOC:rjd, GOC:TermGenie, PMID:23516620]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1902168 ! response to catechin
created_by: rjd
creation_date: 2013-05-22T17:35:40Z

[Term]
id: GO:1902170
name: cellular response to reactive nitrogen species
namespace: biological_process
alt_id: GO:1990106
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive nitrogen species stimulus." [GOC:sl, GOC:TermGenie, PMID:22504638]
is_a: GO:1901699 ! cellular response to nitrogen compound
created_by: tb
creation_date: 2013-05-23T00:23:59Z

[Term]
id: GO:1902171
name: regulation of tocopherol cyclase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tocopherol cyclase activity." [GOC:TermGenie, PMID:23632854]
is_a: GO:0031279 ! regulation of cyclase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009976 ! tocopherol cyclase activity
relationship: regulates GO:0009976 ! tocopherol cyclase activity
created_by: tb
creation_date: 2013-05-25T00:41:14Z

[Term]
id: GO:1902172
name: regulation of keratinocyte apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of keratinocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:18938133]
synonym: "regulation of keratinocyte apoptosis" NARROW [GOC:TermGenie]
is_a: GO:1904035 ! regulation of epithelial cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097283 ! keratinocyte apoptotic process
relationship: regulates GO:0097283 ! keratinocyte apoptotic process
created_by: rl
creation_date: 2013-05-29T14:36:11Z

[Term]
id: GO:1902173
name: negative regulation of keratinocyte apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of keratinocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:18938133]
synonym: "down regulation of keratinocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of keratinocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of keratinocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of keratinocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of keratinocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of keratinocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "inhibition of keratinocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of keratinocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of keratinocyte apoptosis" NARROW [GOC:TermGenie]
is_a: GO:1902172 ! regulation of keratinocyte apoptotic process
is_a: GO:1904036 ! negative regulation of epithelial cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097283 ! keratinocyte apoptotic process
relationship: negatively_regulates GO:0097283 ! keratinocyte apoptotic process
created_by: rl
creation_date: 2013-05-29T14:36:15Z

[Term]
id: GO:1902174
name: positive regulation of keratinocyte apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of keratinocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:18938133]
synonym: "activation of keratinocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of keratinocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of keratinocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of keratinocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of keratinocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of keratinocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of keratinocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of keratinocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of keratinocyte apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:1902172 ! regulation of keratinocyte apoptotic process
is_a: GO:1904037 ! positive regulation of epithelial cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097283 ! keratinocyte apoptotic process
relationship: positively_regulates GO:0097283 ! keratinocyte apoptotic process
created_by: rl
creation_date: 2013-05-29T14:36:21Z

[Term]
id: GO:1902175
name: regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:TermGenie, PMID:11672522]
synonym: "regulation of intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:bf]
is_a: GO:1903201 ! regulation of oxidative stress-induced cell death
is_a: GO:2001242 ! regulation of intrinsic apoptotic signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008631 ! intrinsic apoptotic signaling pathway in response to oxidative stress
relationship: regulates GO:0008631 ! intrinsic apoptotic signaling pathway in response to oxidative stress
created_by: pr
creation_date: 2013-05-29T18:30:00Z

[Term]
id: GO:1902176
name: negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:TermGenie, PMID:11672522]
synonym: "down regulation of intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "downregulation of intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "inhibition of intrinsic apoptotic signaling pathway in response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:bf]
is_a: GO:1902175 ! regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
is_a: GO:1903202 ! negative regulation of oxidative stress-induced cell death
is_a: GO:2001243 ! negative regulation of intrinsic apoptotic signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008631 ! intrinsic apoptotic signaling pathway in response to oxidative stress
relationship: negatively_regulates GO:0008631 ! intrinsic apoptotic signaling pathway in response to oxidative stress
created_by: pr
creation_date: 2013-05-29T18:30:05Z

[Term]
id: GO:1902177
name: positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:TermGenie, PMID:11672522]
synonym: "activation of intrinsic apoptotic signaling pathway in response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "positive regulation of intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:bf]
synonym: "up regulation of intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "upregulation of intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:TermGenie]
is_a: GO:1902175 ! regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
is_a: GO:1903209 ! positive regulation of oxidative stress-induced cell death
is_a: GO:2001244 ! positive regulation of intrinsic apoptotic signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008631 ! intrinsic apoptotic signaling pathway in response to oxidative stress
relationship: positively_regulates GO:0008631 ! intrinsic apoptotic signaling pathway in response to oxidative stress
created_by: pr
creation_date: 2013-05-29T18:30:10Z

[Term]
id: GO:1902178
name: fibroblast growth factor receptor apoptotic signaling pathway
namespace: biological_process
def: "An apoptotic signaling pathway that starts with a ligand binding to, or being withdrawn from, a fibroblast growth factor receptor (FGFR)." [GOC:mtg_apoptosis, GOC:pm, GOC:pr, GOC:TermGenie, PMID:17561467]
synonym: "FGF receptor signaling pathway involved in apoptosis" NARROW [GOC:TermGenie]
synonym: "FGF receptor signaling pathway involved in apoptotic cell death" EXACT [GOC:TermGenie]
synonym: "FGF receptor signaling pathway involved in apoptotic process" EXACT [GOC:TermGenie]
synonym: "FGF receptor signaling pathway involved in apoptotic program" NARROW [GOC:TermGenie]
synonym: "FGF receptor signaling pathway involved in apoptotic programmed cell death" EXACT [GOC:TermGenie]
synonym: "FGF receptor signaling pathway involved in programmed cell death by apoptosis" EXACT [GOC:TermGenie]
synonym: "FGF receptor signaling pathway involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie]
synonym: "FGF receptor signaling pathway involved in type I programmed cell death" NARROW [GOC:TermGenie]
synonym: "FGF receptor signalling pathway involved in apoptosis" NARROW [GOC:TermGenie]
synonym: "FGF receptor signalling pathway involved in apoptotic cell death" EXACT [GOC:TermGenie]
synonym: "FGF receptor signalling pathway involved in apoptotic process" EXACT [GOC:TermGenie]
synonym: "FGF receptor signalling pathway involved in apoptotic program" NARROW [GOC:TermGenie]
synonym: "FGF receptor signalling pathway involved in apoptotic programmed cell death" EXACT [GOC:TermGenie]
synonym: "FGF receptor signalling pathway involved in programmed cell death by apoptosis" EXACT [GOC:TermGenie]
synonym: "FGF receptor signalling pathway involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie]
synonym: "FGF receptor signalling pathway involved in type I programmed cell death" NARROW [GOC:TermGenie]
synonym: "FGFR signaling pathway involved in apoptosis" NARROW [GOC:TermGenie]
synonym: "FGFR signaling pathway involved in apoptotic cell death" EXACT [GOC:TermGenie]
synonym: "FGFR signaling pathway involved in apoptotic process" EXACT [GOC:TermGenie]
synonym: "FGFR signaling pathway involved in apoptotic program" NARROW [GOC:TermGenie]
synonym: "FGFR signaling pathway involved in apoptotic programmed cell death" EXACT [GOC:TermGenie]
synonym: "FGFR signaling pathway involved in programmed cell death by apoptosis" EXACT [GOC:TermGenie]
synonym: "FGFR signaling pathway involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie]
synonym: "FGFR signaling pathway involved in type I programmed cell death" NARROW [GOC:TermGenie]
synonym: "fibroblast growth factor receptor signaling pathway involved in apoptosis" NARROW [GOC:TermGenie]
synonym: "fibroblast growth factor receptor signaling pathway involved in apoptotic cell death" EXACT [GOC:TermGenie]
synonym: "fibroblast growth factor receptor signaling pathway involved in apoptotic process" EXACT [GOC:pm]
synonym: "fibroblast growth factor receptor signaling pathway involved in apoptotic program" NARROW [GOC:TermGenie]
synonym: "fibroblast growth factor receptor signaling pathway involved in apoptotic programmed cell death" EXACT [GOC:TermGenie]
synonym: "fibroblast growth factor receptor signaling pathway involved in programmed cell death by apoptosis" EXACT [GOC:TermGenie]
synonym: "fibroblast growth factor receptor signaling pathway involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie]
synonym: "fibroblast growth factor receptor signaling pathway involved in type I programmed cell death" NARROW [GOC:TermGenie]
synonym: "fibroblast growth factor receptor signalling pathway involved in apoptosis" NARROW [GOC:TermGenie]
synonym: "fibroblast growth factor receptor signalling pathway involved in apoptotic cell death" EXACT [GOC:TermGenie]
synonym: "fibroblast growth factor receptor signalling pathway involved in apoptotic process" EXACT [GOC:TermGenie]
synonym: "fibroblast growth factor receptor signalling pathway involved in apoptotic program" NARROW [GOC:TermGenie]
synonym: "fibroblast growth factor receptor signalling pathway involved in apoptotic programmed cell death" EXACT [GOC:TermGenie]
synonym: "fibroblast growth factor receptor signalling pathway involved in programmed cell death by apoptosis" EXACT [GOC:TermGenie]
synonym: "fibroblast growth factor receptor signalling pathway involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie]
synonym: "fibroblast growth factor receptor signalling pathway involved in type I programmed cell death" NARROW [GOC:TermGenie]
is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway
is_a: GO:0097191 ! extrinsic apoptotic signaling pathway
created_by: pm
creation_date: 2013-05-30T13:59:57Z

[Term]
id: GO:1902179
name: verruculogen metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving verruculogen." [GOC:di, GOC:TermGenie, PMID:23649274]
synonym: "verruculogen metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0018904 ! ether metabolic process
is_a: GO:0034311 ! diol metabolic process
is_a: GO:0035834 ! indole alkaloid metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
created_by: di
creation_date: 2013-05-30T17:44:25Z

[Term]
id: GO:1902180
name: verruculogen catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of verruculogen." [GOC:di, GOC:TermGenie, PMID:23649274]
synonym: "verruculogen breakdown" EXACT [GOC:TermGenie]
synonym: "verruculogen catabolism" EXACT [GOC:TermGenie]
synonym: "verruculogen degradation" EXACT [GOC:TermGenie]
is_a: GO:0009822 ! alkaloid catabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0034313 ! diol catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901502 ! ether catabolic process
is_a: GO:1902179 ! verruculogen metabolic process
created_by: di
creation_date: 2013-05-30T17:44:30Z

[Term]
id: GO:1902181
name: verruculogen biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of verruculogen." [GOC:di, GOC:TermGenie, PMID:23649274]
synonym: "verruculogen anabolism" EXACT [GOC:TermGenie]
synonym: "verruculogen biosynthesis" EXACT [GOC:TermGenie]
synonym: "verruculogen formation" EXACT [GOC:TermGenie]
synonym: "verruculogen synthesis" EXACT [GOC:TermGenie]
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0034312 ! diol biosynthetic process
is_a: GO:0035835 ! indole alkaloid biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901503 ! ether biosynthetic process
is_a: GO:1902179 ! verruculogen metabolic process
created_by: di
creation_date: 2013-05-30T17:44:35Z

[Term]
id: GO:1902182
name: shoot apical meristem development
namespace: biological_process
def: "The process whose specific outcome is the progression of a shoot apical meristem over time, from its formation to the mature structure." [GOC:TermGenie, PMID:21496644]
synonym: "primary shoot meristem development" RELATED [GOC:TermGenie]
synonym: "promeristem development" BROAD [GOC:TermGenie]
synonym: "SAM development" EXACT [GOC:TermGenie]
is_a: GO:0048507 ! meristem development
created_by: tb
creation_date: 2013-05-30T23:13:21Z

[Term]
id: GO:1902183
name: regulation of shoot apical meristem development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of shoot apical meristem development." [GOC:TermGenie, PMID:21496644]
synonym: "regulation of primary shoot meristem development" RELATED [GOC:TermGenie]
synonym: "regulation of promeristem development" BROAD [GOC:TermGenie]
synonym: "regulation of SAM development" EXACT [GOC:TermGenie]
is_a: GO:0048509 ! regulation of meristem development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1902182 ! shoot apical meristem development
relationship: regulates GO:1902182 ! shoot apical meristem development
created_by: tb
creation_date: 2013-05-31T16:33:55Z

[Term]
id: GO:1902184
name: negative regulation of shoot apical meristem development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of shoot apical meristem development." [GOC:TermGenie, PMID:21496644]
synonym: "down regulation of primary shoot meristem development" RELATED [GOC:TermGenie]
synonym: "down regulation of promeristem development" BROAD [GOC:TermGenie]
synonym: "down regulation of SAM development" EXACT [GOC:TermGenie]
synonym: "down regulation of shoot apical meristem development" EXACT [GOC:TermGenie]
synonym: "down-regulation of primary shoot meristem development" RELATED [GOC:TermGenie]
synonym: "down-regulation of promeristem development" BROAD [GOC:TermGenie]
synonym: "down-regulation of SAM development" EXACT [GOC:TermGenie]
synonym: "down-regulation of shoot apical meristem development" EXACT [GOC:TermGenie]
synonym: "downregulation of primary shoot meristem development" RELATED [GOC:TermGenie]
synonym: "downregulation of promeristem development" BROAD [GOC:TermGenie]
synonym: "downregulation of SAM development" EXACT [GOC:TermGenie]
synonym: "downregulation of shoot apical meristem development" EXACT [GOC:TermGenie]
synonym: "inhibition of primary shoot meristem development" RELATED [GOC:TermGenie]
synonym: "inhibition of promeristem development" BROAD [GOC:TermGenie]
synonym: "inhibition of SAM development" EXACT [GOC:TermGenie]
synonym: "inhibition of shoot apical meristem development" NARROW [GOC:TermGenie]
synonym: "negative regulation of primary shoot meristem development" RELATED [GOC:TermGenie]
synonym: "negative regulation of promeristem development" BROAD [GOC:TermGenie]
synonym: "negative regulation of SAM development" EXACT [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1902183 ! regulation of shoot apical meristem development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1902182 ! shoot apical meristem development
relationship: negatively_regulates GO:1902182 ! shoot apical meristem development
created_by: tb
creation_date: 2013-05-31T16:34:00Z

[Term]
id: GO:1902185
name: positive regulation of shoot apical meristem development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of shoot apical meristem development." [GOC:TermGenie, PMID:21496644]
synonym: "activation of primary shoot meristem development" RELATED [GOC:TermGenie]
synonym: "activation of promeristem development" BROAD [GOC:TermGenie]
synonym: "activation of SAM development" EXACT [GOC:TermGenie]
synonym: "activation of shoot apical meristem development" NARROW [GOC:TermGenie]
synonym: "positive regulation of primary shoot meristem development" RELATED [GOC:TermGenie]
synonym: "positive regulation of promeristem development" BROAD [GOC:TermGenie]
synonym: "positive regulation of SAM development" EXACT [GOC:TermGenie]
synonym: "up regulation of primary shoot meristem development" RELATED [GOC:TermGenie]
synonym: "up regulation of promeristem development" BROAD [GOC:TermGenie]
synonym: "up regulation of SAM development" EXACT [GOC:TermGenie]
synonym: "up regulation of shoot apical meristem development" EXACT [GOC:TermGenie]
synonym: "up-regulation of primary shoot meristem development" RELATED [GOC:TermGenie]
synonym: "up-regulation of promeristem development" BROAD [GOC:TermGenie]
synonym: "up-regulation of SAM development" EXACT [GOC:TermGenie]
synonym: "up-regulation of shoot apical meristem development" EXACT [GOC:TermGenie]
synonym: "upregulation of primary shoot meristem development" RELATED [GOC:TermGenie]
synonym: "upregulation of promeristem development" BROAD [GOC:TermGenie]
synonym: "upregulation of SAM development" EXACT [GOC:TermGenie]
synonym: "upregulation of shoot apical meristem development" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1902183 ! regulation of shoot apical meristem development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1902182 ! shoot apical meristem development
relationship: positively_regulates GO:1902182 ! shoot apical meristem development
created_by: tb
creation_date: 2013-05-31T16:34:05Z

[Term]
id: GO:1902186
name: regulation of viral release from host cell
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of viral release from host cell." [GOC:TermGenie, PMID:18305167]
synonym: "regulation of release of virus from host" EXACT [GOC:TermGenie]
synonym: "regulation of viral exit" EXACT [GOC:TermGenie]
synonym: "regulation of viral release" EXACT [GOC:TermGenie]
synonym: "regulation of viral shedding" EXACT [GOC:TermGenie]
is_a: GO:1903900 ! regulation of viral life cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019076 ! viral release from host cell
relationship: regulates GO:0019076 ! viral release from host cell
created_by: ss
creation_date: 2013-06-04T03:54:03Z

[Term]
id: GO:1902187
name: negative regulation of viral release from host cell
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of viral release from host cell." [GOC:TermGenie, PMID:18305167]
synonym: "down regulation of release of virus from host" EXACT [GOC:TermGenie]
synonym: "down regulation of viral exit" EXACT [GOC:TermGenie]
synonym: "down regulation of viral release" EXACT [GOC:TermGenie]
synonym: "down regulation of viral release from host cell" EXACT [GOC:TermGenie]
synonym: "down regulation of viral shedding" EXACT [GOC:TermGenie]
synonym: "down-regulation of release of virus from host" EXACT [GOC:TermGenie]
synonym: "down-regulation of viral exit" EXACT [GOC:TermGenie]
synonym: "down-regulation of viral release" EXACT [GOC:TermGenie]
synonym: "down-regulation of viral release from host cell" EXACT [GOC:TermGenie]
synonym: "down-regulation of viral shedding" EXACT [GOC:TermGenie]
synonym: "downregulation of release of virus from host" EXACT [GOC:TermGenie]
synonym: "downregulation of viral exit" EXACT [GOC:TermGenie]
synonym: "downregulation of viral release" EXACT [GOC:TermGenie]
synonym: "downregulation of viral release from host cell" EXACT [GOC:TermGenie]
synonym: "downregulation of viral shedding" EXACT [GOC:TermGenie]
synonym: "inhibition of release of virus from host" EXACT [GOC:TermGenie]
synonym: "inhibition of viral exit" EXACT [GOC:TermGenie]
synonym: "inhibition of viral release" EXACT [GOC:TermGenie]
synonym: "inhibition of viral release from host cell" NARROW [GOC:TermGenie]
synonym: "inhibition of viral shedding" EXACT [GOC:TermGenie]
synonym: "negative regulation of release of virus from host" EXACT [GOC:TermGenie]
synonym: "negative regulation of viral exit" EXACT [GOC:TermGenie]
synonym: "negative regulation of viral release" EXACT [GOC:TermGenie]
synonym: "negative regulation of viral shedding" EXACT [GOC:TermGenie]
is_a: GO:1902186 ! regulation of viral release from host cell
is_a: GO:1903901 ! negative regulation of viral life cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019076 ! viral release from host cell
relationship: negatively_regulates GO:0019076 ! viral release from host cell
created_by: ss
creation_date: 2013-06-04T03:54:08Z

[Term]
id: GO:1902188
name: positive regulation of viral release from host cell
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of viral release from host cell." [GOC:TermGenie, PMID:18305167]
synonym: "activation of release of virus from host" EXACT [GOC:TermGenie]
synonym: "activation of viral exit" EXACT [GOC:TermGenie]
synonym: "activation of viral release" EXACT [GOC:TermGenie]
synonym: "activation of viral release from host cell" NARROW [GOC:TermGenie]
synonym: "activation of viral shedding" EXACT [GOC:TermGenie]
synonym: "positive regulation of release of virus from host" EXACT [GOC:TermGenie]
synonym: "positive regulation of viral exit" EXACT [GOC:TermGenie]
synonym: "positive regulation of viral release" EXACT [GOC:TermGenie]
synonym: "positive regulation of viral shedding" EXACT [GOC:TermGenie]
synonym: "up regulation of release of virus from host" EXACT [GOC:TermGenie]
synonym: "up regulation of viral exit" EXACT [GOC:TermGenie]
synonym: "up regulation of viral release" EXACT [GOC:TermGenie]
synonym: "up regulation of viral release from host cell" EXACT [GOC:TermGenie]
synonym: "up regulation of viral shedding" EXACT [GOC:TermGenie]
synonym: "up-regulation of release of virus from host" EXACT [GOC:TermGenie]
synonym: "up-regulation of viral exit" EXACT [GOC:TermGenie]
synonym: "up-regulation of viral release" EXACT [GOC:TermGenie]
synonym: "up-regulation of viral release from host cell" EXACT [GOC:TermGenie]
synonym: "up-regulation of viral shedding" EXACT [GOC:TermGenie]
synonym: "upregulation of release of virus from host" EXACT [GOC:TermGenie]
synonym: "upregulation of viral exit" EXACT [GOC:TermGenie]
synonym: "upregulation of viral release" EXACT [GOC:TermGenie]
synonym: "upregulation of viral release from host cell" EXACT [GOC:TermGenie]
synonym: "upregulation of viral shedding" EXACT [GOC:TermGenie]
is_a: GO:1902186 ! regulation of viral release from host cell
is_a: GO:1903902 ! positive regulation of viral life cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0019076 ! viral release from host cell
relationship: positively_regulates GO:0019076 ! viral release from host cell
created_by: ss
creation_date: 2013-06-04T03:54:14Z

[Term]
id: GO:1902189
name: 2-methylbutanoyl-CoA(4-) metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 2-methylbutanoyl-CoA(4-)." [GOC:TermGenie, pubmed:15574432]
synonym: "2-methylbutanoyl-CoA(4-) metabolism" EXACT [GOC:TermGenie]
is_a: GO:0035337 ! fatty-acyl-CoA metabolic process
created_by: ms
creation_date: 2013-06-06T09:40:14Z

[Term]
id: GO:1902190
name: 2-methylbutanoyl-CoA(4-) catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 2-methylbutanoyl-CoA(4-)." [GOC:TermGenie, pubmed:15574432]
synonym: "2-methylbutanoyl-CoA(4-) breakdown" EXACT [GOC:TermGenie]
synonym: "2-methylbutanoyl-CoA(4-) catabolism" EXACT [GOC:TermGenie]
synonym: "2-methylbutanoyl-CoA(4-) degradation" EXACT [GOC:TermGenie]
is_a: GO:0036115 ! fatty-acyl-CoA catabolic process
is_a: GO:1902189 ! 2-methylbutanoyl-CoA(4-) metabolic process
created_by: ms
creation_date: 2013-06-06T09:40:20Z

[Term]
id: GO:1902191
name: 2-methylbutanoyl-CoA(4-) biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 2-methylbutanoyl-CoA(4-)." [GOC:TermGenie, pubmed:15574432]
synonym: "2-methylbutanoyl-CoA(4-) anabolism" EXACT [GOC:TermGenie]
synonym: "2-methylbutanoyl-CoA(4-) biosynthesis" EXACT [GOC:TermGenie]
synonym: "2-methylbutanoyl-CoA(4-) formation" EXACT [GOC:TermGenie]
synonym: "2-methylbutanoyl-CoA(4-) synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046949 ! fatty-acyl-CoA biosynthetic process
is_a: GO:1902189 ! 2-methylbutanoyl-CoA(4-) metabolic process
created_by: ms
creation_date: 2013-06-06T09:40:25Z

[Term]
id: GO:1902192
name: 2-methylbut-2-enoyl-CoA(4-) metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 2-methylbut-2-enoyl-CoA(4-)." [GOC:TermGenie, pubmed:15574432]
synonym: "2-methylbut-2-enoyl-CoA(4-) metabolism" EXACT [GOC:TermGenie]
is_a: GO:0035337 ! fatty-acyl-CoA metabolic process
created_by: ms
creation_date: 2013-06-06T09:40:30Z

[Term]
id: GO:1902193
name: 2-methylbut-2-enoyl-CoA(4-) catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 2-methylbut-2-enoyl-CoA(4-)." [GOC:TermGenie, pubmed:15574432]
synonym: "2-methylbut-2-enoyl-CoA(4-) breakdown" EXACT [GOC:TermGenie]
synonym: "2-methylbut-2-enoyl-CoA(4-) catabolism" EXACT [GOC:TermGenie]
synonym: "2-methylbut-2-enoyl-CoA(4-) degradation" EXACT [GOC:TermGenie]
is_a: GO:0036115 ! fatty-acyl-CoA catabolic process
is_a: GO:1902192 ! 2-methylbut-2-enoyl-CoA(4-) metabolic process
created_by: ms
creation_date: 2013-06-06T09:40:41Z

[Term]
id: GO:1902194
name: 2-methylbut-2-enoyl-CoA(4-) biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 2-methylbut-2-enoyl-CoA(4-)." [GOC:TermGenie, pubmed:15574432]
synonym: "2-methylbut-2-enoyl-CoA(4-) anabolism" EXACT [GOC:TermGenie]
synonym: "2-methylbut-2-enoyl-CoA(4-) biosynthesis" EXACT [GOC:TermGenie]
synonym: "2-methylbut-2-enoyl-CoA(4-) formation" EXACT [GOC:TermGenie]
synonym: "2-methylbut-2-enoyl-CoA(4-) synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046949 ! fatty-acyl-CoA biosynthetic process
is_a: GO:1902192 ! 2-methylbut-2-enoyl-CoA(4-) metabolic process
created_by: ms
creation_date: 2013-06-06T09:40:46Z

[Term]
id: GO:1902195
name: isovaleryl-CoA(4-) metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving isovaleryl-CoA(4-)." [GOC:TermGenie, pmid:11231285]
synonym: "isovaleryl-CoA(4-) metabolism" EXACT [GOC:TermGenie]
is_a: GO:0035337 ! fatty-acyl-CoA metabolic process
created_by: ms
creation_date: 2013-06-06T09:55:55Z

[Term]
id: GO:1902196
name: isovaleryl-CoA(4-) catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of isovaleryl-CoA(4-)." [GOC:TermGenie, pmid:11231285]
synonym: "isovaleryl-CoA(4-) breakdown" EXACT [GOC:TermGenie]
synonym: "isovaleryl-CoA(4-) catabolism" EXACT [GOC:TermGenie]
synonym: "isovaleryl-CoA(4-) degradation" EXACT [GOC:TermGenie]
is_a: GO:0036115 ! fatty-acyl-CoA catabolic process
is_a: GO:1902195 ! isovaleryl-CoA(4-) metabolic process
created_by: ms
creation_date: 2013-06-06T09:56:00Z

[Term]
id: GO:1902197
name: isovaleryl-CoA(4-) biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of isovaleryl-CoA(4-)." [GOC:TermGenie, pmid:11231285]
synonym: "isovaleryl-CoA(4-) anabolism" EXACT [GOC:TermGenie]
synonym: "isovaleryl-CoA(4-) biosynthesis" EXACT [GOC:TermGenie]
synonym: "isovaleryl-CoA(4-) formation" EXACT [GOC:TermGenie]
synonym: "isovaleryl-CoA(4-) synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046949 ! fatty-acyl-CoA biosynthetic process
is_a: GO:1902195 ! isovaleryl-CoA(4-) metabolic process
created_by: ms
creation_date: 2013-06-06T09:56:05Z

[Term]
id: GO:1902198
name: 3-methylbut-2-enoyl-CoA(4-) metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 3-methylbut-2-enoyl-CoA(4-)." [GOC:TermGenie, pmid:11231285]
synonym: "3-methylbut-2-enoyl-CoA(4-) metabolism" EXACT [GOC:TermGenie]
is_a: GO:0035337 ! fatty-acyl-CoA metabolic process
created_by: ms
creation_date: 2013-06-06T09:56:11Z

[Term]
id: GO:1902199
name: 3-methylbut-2-enoyl-CoA(4-) catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 3-methylbut-2-enoyl-CoA(4-)." [GOC:TermGenie, pmid:11231285]
synonym: "3-methylbut-2-enoyl-CoA(4-) breakdown" EXACT [GOC:TermGenie]
synonym: "3-methylbut-2-enoyl-CoA(4-) catabolism" EXACT [GOC:TermGenie]
synonym: "3-methylbut-2-enoyl-CoA(4-) degradation" EXACT [GOC:TermGenie]
is_a: GO:0036115 ! fatty-acyl-CoA catabolic process
is_a: GO:1902198 ! 3-methylbut-2-enoyl-CoA(4-) metabolic process
created_by: ms
creation_date: 2013-06-06T09:56:16Z

[Term]
id: GO:1902200
name: 3-methylbut-2-enoyl-CoA(4-) biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 3-methylbut-2-enoyl-CoA(4-)." [GOC:TermGenie, pmid:11231285]
synonym: "3-methylbut-2-enoyl-CoA(4-) anabolism" EXACT [GOC:TermGenie]
synonym: "3-methylbut-2-enoyl-CoA(4-) biosynthesis" EXACT [GOC:TermGenie]
synonym: "3-methylbut-2-enoyl-CoA(4-) formation" EXACT [GOC:TermGenie]
synonym: "3-methylbut-2-enoyl-CoA(4-) synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046949 ! fatty-acyl-CoA biosynthetic process
is_a: GO:1902198 ! 3-methylbut-2-enoyl-CoA(4-) metabolic process
created_by: ms
creation_date: 2013-06-06T09:56:21Z

[Term]
id: GO:1902201
name: negative regulation of bacterial-type flagellum-dependent cell motility
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of bacterial-type flagellum-dependent cell motility." [GOC:cilia, GOC:jl, GOC:TermGenie]
synonym: "down regulation of bacterial-type flagellar cell motility" EXACT [GOC:TermGenie]
synonym: "down regulation of flagellin-based flagellar cell motility" EXACT [GOC:TermGenie]
synonym: "down-regulation of bacterial-type flagellar cell motility" EXACT [GOC:TermGenie]
synonym: "down-regulation of flagellin-based flagellar cell motility" EXACT [GOC:TermGenie]
synonym: "downregulation of bacterial-type flagellar cell motility" EXACT [GOC:TermGenie]
synonym: "downregulation of flagellin-based flagellar cell motility" EXACT [GOC:TermGenie]
synonym: "inhibition of bacterial-type flagellar cell motility" NARROW [GOC:TermGenie]
synonym: "inhibition of flagellin-based flagellar cell motility" EXACT [GOC:TermGenie]
synonym: "negative regulation of bacterial-type flagellar cell motility" RELATED []
synonym: "negative regulation of flagellin-based flagellar cell motility" EXACT [GOC:TermGenie]
is_a: GO:1902021 ! regulation of bacterial-type flagellum-dependent cell motility
is_a: GO:2000146 ! negative regulation of cell motility
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071973 ! bacterial-type flagellum-dependent cell motility
relationship: negatively_regulates GO:0071973 ! bacterial-type flagellum-dependent cell motility
created_by: jl
creation_date: 2013-06-06T14:58:41Z

[Term]
id: GO:1902202
name: regulation of hepatocyte growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hepatocyte growth factor receptor signaling pathway." [GOC:TermGenie, PMID:18819921]
synonym: "regulation of HGF receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "regulation of HGF receptor signalling pathway" EXACT [GOC:TermGenie]
synonym: "regulation of Met signaling pathway" NARROW [GOC:TermGenie]
is_a: GO:0009966 ! regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048012 ! hepatocyte growth factor receptor signaling pathway
relationship: regulates GO:0048012 ! hepatocyte growth factor receptor signaling pathway
created_by: lb
creation_date: 2013-06-10T13:20:45Z

[Term]
id: GO:1902203
name: negative regulation of hepatocyte growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hepatocyte growth factor receptor signaling pathway." [GOC:TermGenie, PMID:18819921]
synonym: "down regulation of hepatocyte growth factor receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of HGF receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of HGF receptor signalling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of Met signaling pathway" NARROW [GOC:TermGenie]
synonym: "down-regulation of hepatocyte growth factor receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of HGF receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of HGF receptor signalling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of Met signaling pathway" NARROW [GOC:TermGenie]
synonym: "downregulation of hepatocyte growth factor receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of HGF receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of HGF receptor signalling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of Met signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of hepatocyte growth factor receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of HGF receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of HGF receptor signalling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of Met signaling pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of HGF receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of HGF receptor signalling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of Met signaling pathway" NARROW [GOC:TermGenie]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:1902202 ! regulation of hepatocyte growth factor receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048012 ! hepatocyte growth factor receptor signaling pathway
relationship: negatively_regulates GO:0048012 ! hepatocyte growth factor receptor signaling pathway
created_by: lb
creation_date: 2013-06-10T13:20:51Z

[Term]
id: GO:1902204
name: positive regulation of hepatocyte growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hepatocyte growth factor receptor signaling pathway." [GOC:TermGenie, PMID:18819921]
synonym: "activation of hepatocyte growth factor receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of HGF receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "activation of HGF receptor signalling pathway" EXACT [GOC:TermGenie]
synonym: "activation of Met signaling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of HGF receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of HGF receptor signalling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of Met signaling pathway" NARROW [GOC:TermGenie]
synonym: "up regulation of hepatocyte growth factor receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of HGF receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of HGF receptor signalling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of Met signaling pathway" NARROW [GOC:TermGenie]
synonym: "up-regulation of hepatocyte growth factor receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of HGF receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of HGF receptor signalling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of Met signaling pathway" NARROW [GOC:TermGenie]
synonym: "upregulation of hepatocyte growth factor receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of HGF receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of HGF receptor signalling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of Met signaling pathway" NARROW [GOC:TermGenie]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:1902202 ! regulation of hepatocyte growth factor receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048012 ! hepatocyte growth factor receptor signaling pathway
relationship: positively_regulates GO:0048012 ! hepatocyte growth factor receptor signaling pathway
created_by: lb
creation_date: 2013-06-10T13:20:56Z

[Term]
id: GO:1902205
name: regulation of interleukin-2-mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of interleukin-2-mediated signaling pathway." [GOC:TermGenie, PMID:11909529]
synonym: "regulation of IL-2-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "regulation of interleukin-2-mediated signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0038110 ! interleukin-2-mediated signaling pathway
relationship: regulates GO:0038110 ! interleukin-2-mediated signaling pathway
created_by: lb
creation_date: 2013-06-11T07:34:39Z

[Term]
id: GO:1902206
name: negative regulation of interleukin-2-mediated signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-2-mediated signaling pathway." [GOC:TermGenie, PMID:11909529]
synonym: "down regulation of IL-2-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of interleukin-2-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of interleukin-2-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of IL-2-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of interleukin-2-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of interleukin-2-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of IL-2-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of interleukin-2-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of interleukin-2-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of IL-2-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of interleukin-2-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of interleukin-2-mediated signalling pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of IL-2-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of interleukin-2-mediated signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway
is_a: GO:1902205 ! regulation of interleukin-2-mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0038110 ! interleukin-2-mediated signaling pathway
relationship: negatively_regulates GO:0038110 ! interleukin-2-mediated signaling pathway
created_by: lb
creation_date: 2013-06-11T07:34:45Z

[Term]
id: GO:1902207
name: positive regulation of interleukin-2-mediated signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of interleukin-2-mediated signaling pathway." [GOC:TermGenie, PMID:11909529]
synonym: "activation of IL-2-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of interleukin-2-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of interleukin-2-mediated signalling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of IL-2-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of interleukin-2-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of IL-2-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of interleukin-2-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of interleukin-2-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of IL-2-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of interleukin-2-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of interleukin-2-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of IL-2-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of interleukin-2-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of interleukin-2-mediated signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway
is_a: GO:1902205 ! regulation of interleukin-2-mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0038110 ! interleukin-2-mediated signaling pathway
relationship: positively_regulates GO:0038110 ! interleukin-2-mediated signaling pathway
created_by: lb
creation_date: 2013-06-11T07:34:50Z

[Term]
id: GO:1902208
name: regulation of bacterial-type flagellum assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of bacterial-type flagellum assembly." [GOC:jl, GOC:TermGenie]
synonym: "regulation of bacterial flagellum assembly" EXACT [GOC:TermGenie]
is_a: GO:0060491 ! regulation of cell projection assembly
is_a: GO:1902115 ! regulation of organelle assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044780 ! bacterial-type flagellum assembly
relationship: regulates GO:0044780 ! bacterial-type flagellum assembly
created_by: jl
creation_date: 2013-06-11T14:20:19Z

[Term]
id: GO:1902209
name: negative regulation of bacterial-type flagellum assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of bacterial-type flagellum assembly." [GOC:jl, GOC:TermGenie]
synonym: "down regulation of bacterial flagellum assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of bacterial-type flagellum assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of bacterial flagellum assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of bacterial-type flagellum assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of bacterial flagellum assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of bacterial-type flagellum assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of bacterial flagellum assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of bacterial-type flagellum assembly" NARROW [GOC:TermGenie]
synonym: "negative regulation of bacterial flagellum assembly" EXACT [GOC:TermGenie]
is_a: GO:0031345 ! negative regulation of cell projection organization
is_a: GO:1902116 ! negative regulation of organelle assembly
is_a: GO:1902208 ! regulation of bacterial-type flagellum assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044780 ! bacterial-type flagellum assembly
relationship: negatively_regulates GO:0044780 ! bacterial-type flagellum assembly
created_by: jl
creation_date: 2013-06-11T14:20:24Z

[Term]
id: GO:1902210
name: positive regulation of bacterial-type flagellum assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of bacterial-type flagellum assembly." [GOC:jl, GOC:TermGenie]
synonym: "activation of bacterial flagellum assembly" NARROW [GOC:TermGenie]
synonym: "activation of bacterial-type flagellum assembly" NARROW [GOC:TermGenie]
synonym: "positive regulation of bacterial flagellum assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of bacterial flagellum assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of bacterial-type flagellum assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of bacterial flagellum assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of bacterial-type flagellum assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of bacterial flagellum assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of bacterial-type flagellum assembly" EXACT [GOC:TermGenie]
is_a: GO:0031346 ! positive regulation of cell projection organization
is_a: GO:1902117 ! positive regulation of organelle assembly
is_a: GO:1902208 ! regulation of bacterial-type flagellum assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044780 ! bacterial-type flagellum assembly
relationship: positively_regulates GO:0044780 ! bacterial-type flagellum assembly
created_by: jl
creation_date: 2013-06-11T14:20:30Z

[Term]
id: GO:1902211
name: regulation of prolactin signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of prolactin signaling pathway." [GOC:TermGenie, PMID:11773439]
synonym: "regulation of PRL signaling pathway" EXACT [GOC:TermGenie]
synonym: "regulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0038161 ! prolactin signaling pathway
relationship: regulates GO:0038161 ! prolactin signaling pathway
created_by: lb
creation_date: 2013-06-12T10:10:07Z

[Term]
id: GO:1902212
name: negative regulation of prolactin signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of prolactin signaling pathway." [GOC:TermGenie, PMID:11773439]
synonym: "down regulation of PRL signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of prolactin signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of PRL signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of prolactin signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of PRL signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of prolactin signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of PRL signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of prolactin signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of prolactin-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of PRL signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway
is_a: GO:1902211 ! regulation of prolactin signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0038161 ! prolactin signaling pathway
relationship: negatively_regulates GO:0038161 ! prolactin signaling pathway
created_by: lb
creation_date: 2013-06-12T10:10:12Z

[Term]
id: GO:1902213
name: positive regulation of prolactin signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of prolactin signaling pathway." [GOC:TermGenie, PMID:11773439]
synonym: "activation of PRL signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of prolactin signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of prolactin-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of PRL signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of PRL signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of prolactin signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of PRL signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of prolactin signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of PRL signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of prolactin signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway
is_a: GO:1902211 ! regulation of prolactin signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0038161 ! prolactin signaling pathway
relationship: positively_regulates GO:0038161 ! prolactin signaling pathway
created_by: lb
creation_date: 2013-06-12T10:10:18Z

[Term]
id: GO:1902214
name: regulation of interleukin-4-mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of interleukin-4-mediated signaling pathway." [GOC:TermGenie, PMID:17210636]
synonym: "regulation of IL-4-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "regulation of interleukin-4-mediated signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035771 ! interleukin-4-mediated signaling pathway
relationship: regulates GO:0035771 ! interleukin-4-mediated signaling pathway
created_by: lb
creation_date: 2013-06-12T12:53:09Z

[Term]
id: GO:1902215
name: negative regulation of interleukin-4-mediated signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-4-mediated signaling pathway." [GOC:TermGenie, PMID:17210636]
synonym: "down regulation of IL-4-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of interleukin-4-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of interleukin-4-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of IL-4-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of interleukin-4-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of interleukin-4-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of IL-4-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of interleukin-4-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of interleukin-4-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of IL-4-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of interleukin-4-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of interleukin-4-mediated signalling pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of IL-4-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of interleukin-4-mediated signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway
is_a: GO:1902214 ! regulation of interleukin-4-mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035771 ! interleukin-4-mediated signaling pathway
relationship: negatively_regulates GO:0035771 ! interleukin-4-mediated signaling pathway
created_by: lb
creation_date: 2013-06-12T12:53:14Z

[Term]
id: GO:1902216
name: positive regulation of interleukin-4-mediated signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of interleukin-4-mediated signaling pathway." [GOC:TermGenie, PMID:17210636]
synonym: "activation of IL-4-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of interleukin-4-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of interleukin-4-mediated signalling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of IL-4-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of interleukin-4-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of IL-4-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of interleukin-4-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of interleukin-4-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of IL-4-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of interleukin-4-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of interleukin-4-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of IL-4-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of interleukin-4-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of interleukin-4-mediated signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway
is_a: GO:1902214 ! regulation of interleukin-4-mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035771 ! interleukin-4-mediated signaling pathway
relationship: positively_regulates GO:0035771 ! interleukin-4-mediated signaling pathway
created_by: lb
creation_date: 2013-06-12T12:53:20Z

[Term]
id: GO:1902217
name: erythrocyte apoptotic process
namespace: biological_process
def: "Any apoptotic process in an erythrocyte." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084]
synonym: "erythrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "RBC apoptosis" NARROW [GOC:TermGenie]
synonym: "RBC apoptotic process" EXACT [GOC:TermGenie]
synonym: "red blood cell apoptosis" NARROW [GOC:TermGenie]
synonym: "red blood cell apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0033028 ! myeloid cell apoptotic process
created_by: rl
creation_date: 2013-06-13T10:02:29Z

[Term]
id: GO:1902218
name: regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084]
is_a: GO:0047484 ! regulation of response to osmotic stress
is_a: GO:0080135 ! regulation of cellular response to stress
is_a: GO:2001242 ! regulation of intrinsic apoptotic signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008627 ! intrinsic apoptotic signaling pathway in response to osmotic stress
relationship: regulates GO:0008627 ! intrinsic apoptotic signaling pathway in response to osmotic stress
created_by: rl
creation_date: 2013-06-13T10:19:07Z

[Term]
id: GO:1902219
name: negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084]
synonym: "down regulation of intrinsic apoptotic signaling pathway in response to osmotic stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of intrinsic apoptotic signaling pathway in response to osmotic stress" EXACT [GOC:TermGenie]
synonym: "downregulation of intrinsic apoptotic signaling pathway in response to osmotic stress" EXACT [GOC:TermGenie]
synonym: "inhibition of intrinsic apoptotic signaling pathway in response to osmotic stress" NARROW [GOC:TermGenie]
is_a: GO:1902218 ! regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
is_a: GO:2001243 ! negative regulation of intrinsic apoptotic signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008627 ! intrinsic apoptotic signaling pathway in response to osmotic stress
relationship: negatively_regulates GO:0008627 ! intrinsic apoptotic signaling pathway in response to osmotic stress
created_by: rl
creation_date: 2013-06-13T10:19:12Z

[Term]
id: GO:1902220
name: positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084]
synonym: "activation of intrinsic apoptotic signaling pathway in response to osmotic stress" NARROW [GOC:TermGenie]
synonym: "up regulation of intrinsic apoptotic signaling pathway in response to osmotic stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of intrinsic apoptotic signaling pathway in response to osmotic stress" EXACT [GOC:TermGenie]
synonym: "upregulation of intrinsic apoptotic signaling pathway in response to osmotic stress" EXACT [GOC:TermGenie]
is_a: GO:1902218 ! regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
is_a: GO:2001244 ! positive regulation of intrinsic apoptotic signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008627 ! intrinsic apoptotic signaling pathway in response to osmotic stress
relationship: positively_regulates GO:0008627 ! intrinsic apoptotic signaling pathway in response to osmotic stress
created_by: rl
creation_date: 2013-06-13T10:19:18Z

[Term]
id: GO:1902221
name: erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving erythrose 4-phosphate/phosphoenolpyruvate family amino acid." [GOC:pr, GOC:TermGenie]
synonym: "erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolism" EXACT [GOC:TermGenie]
is_a: GO:1901605 ! alpha-amino acid metabolic process
created_by: pr
creation_date: 2013-06-13T10:37:38Z

[Term]
id: GO:1902222
name: erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of erythrose 4-phosphate/phosphoenolpyruvate family amino acid." [GOC:pr, GOC:TermGenie]
synonym: "erythrose 4-phosphate/phosphoenolpyruvate family amino acid breakdown" EXACT [GOC:TermGenie]
synonym: "erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolism" EXACT [GOC:TermGenie]
synonym: "erythrose 4-phosphate/phosphoenolpyruvate family amino acid degradation" EXACT [GOC:TermGenie]
is_a: GO:1901606 ! alpha-amino acid catabolic process
is_a: GO:1902221 ! erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process
created_by: pr
creation_date: 2013-06-13T10:37:43Z

[Term]
id: GO:1902223
name: erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of erythrose 4-phosphate/phosphoenolpyruvate family amino acid." [GOC:pr, GOC:TermGenie]
synonym: "erythrose 4-phosphate/phosphoenolpyruvate family amino acid anabolism" EXACT [GOC:TermGenie]
synonym: "erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "erythrose 4-phosphate/phosphoenolpyruvate family amino acid formation" EXACT [GOC:TermGenie]
synonym: "erythrose 4-phosphate/phosphoenolpyruvate family amino acid synthesis" EXACT [GOC:TermGenie]
is_a: GO:1901607 ! alpha-amino acid biosynthetic process
is_a: GO:1902221 ! erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process
created_by: pr
creation_date: 2013-06-13T10:37:49Z

[Term]
id: GO:1902224
name: ketone body metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ketone body." [GOC:pr, GOC:TermGenie]
synonym: "ketone body metabolism" EXACT [GOC:TermGenie]
is_a: GO:0071704 ! organic substance metabolic process
created_by: pr
creation_date: 2013-06-13T10:37:54Z

[Term]
id: GO:1902225
name: negative regulation of acrosome reaction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of acrosome reaction." [GOC:TermGenie, PMID:23430248]
synonym: "down regulation of acrosome reaction" EXACT [GOC:TermGenie]
synonym: "down-regulation of acrosome reaction" EXACT [GOC:TermGenie]
synonym: "downregulation of acrosome reaction" EXACT [GOC:TermGenie]
synonym: "inhibition of acrosome reaction" NARROW [GOC:TermGenie]
is_a: GO:0045955 ! negative regulation of calcium ion-dependent exocytosis
is_a: GO:0060046 ! regulation of acrosome reaction
is_a: GO:0060467 ! negative regulation of fertilization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007340 ! acrosome reaction
relationship: negatively_regulates GO:0007340 ! acrosome reaction
created_by: Anne.Estreicher
creation_date: 2013-06-13T14:17:11Z

[Term]
id: GO:1902226
name: regulation of macrophage colony-stimulating factor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of macrophage colony-stimulating factor signaling pathway." [GOC:TermGenie, PMID:16705167]
synonym: "regulation of M-CSF signaling pathway" EXACT [GOC:TermGenie]
synonym: "regulation of macrophage colony-stimulating factor signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway
is_a: GO:1903972 ! regulation of cellular response to macrophage colony-stimulating factor stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0038145 ! macrophage colony-stimulating factor signaling pathway
relationship: regulates GO:0038145 ! macrophage colony-stimulating factor signaling pathway
created_by: lb
creation_date: 2013-06-14T06:28:42Z

[Term]
id: GO:1902227
name: negative regulation of macrophage colony-stimulating factor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of macrophage colony-stimulating factor signaling pathway." [GOC:TermGenie, PMID:16705167]
synonym: "down regulation of M-CSF signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of macrophage colony-stimulating factor signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of macrophage colony-stimulating factor signalling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of M-CSF signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of macrophage colony-stimulating factor signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of macrophage colony-stimulating factor signalling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of M-CSF signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of macrophage colony-stimulating factor signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of macrophage colony-stimulating factor signalling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of M-CSF signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of macrophage colony-stimulating factor signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of macrophage colony-stimulating factor signalling pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of M-CSF signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of macrophage colony-stimulating factor signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway
is_a: GO:1902226 ! regulation of macrophage colony-stimulating factor signaling pathway
is_a: GO:1903973 ! negative regulation of cellular response to macrophage colony-stimulating factor stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0038145 ! macrophage colony-stimulating factor signaling pathway
relationship: negatively_regulates GO:0038145 ! macrophage colony-stimulating factor signaling pathway
created_by: lb
creation_date: 2013-06-14T06:28:54Z

[Term]
id: GO:1902228
name: positive regulation of macrophage colony-stimulating factor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of macrophage colony-stimulating factor signaling pathway." [GOC:TermGenie, PMID:16705167]
synonym: "activation of M-CSF signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of macrophage colony-stimulating factor signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of macrophage colony-stimulating factor signalling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of M-CSF signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of macrophage colony-stimulating factor signalling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of M-CSF signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of macrophage colony-stimulating factor signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of macrophage colony-stimulating factor signalling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of M-CSF signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of macrophage colony-stimulating factor signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of macrophage colony-stimulating factor signalling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of M-CSF signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of macrophage colony-stimulating factor signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of macrophage colony-stimulating factor signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway
is_a: GO:1902226 ! regulation of macrophage colony-stimulating factor signaling pathway
is_a: GO:1903974 ! positive regulation of cellular response to macrophage colony-stimulating factor stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0038145 ! macrophage colony-stimulating factor signaling pathway
relationship: positively_regulates GO:0038145 ! macrophage colony-stimulating factor signaling pathway
created_by: lb
creation_date: 2013-06-14T06:29:00Z

[Term]
id: GO:1902229
name: regulation of intrinsic apoptotic signaling pathway in response to DNA damage
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:15314165]
synonym: "regulation of DNA damage response, signal transduction resulting in induction of apoptosis" RELATED [GOC:TermGenie]
is_a: GO:2001020 ! regulation of response to DNA damage stimulus
is_a: GO:2001242 ! regulation of intrinsic apoptotic signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008630 ! intrinsic apoptotic signaling pathway in response to DNA damage
relationship: regulates GO:0008630 ! intrinsic apoptotic signaling pathway in response to DNA damage
created_by: rl
creation_date: 2013-06-14T09:39:52Z

[Term]
id: GO:1902230
name: negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:15314165]
synonym: "down regulation of DNA damage response, signal transduction resulting in induction of apoptosis" RELATED [GOC:TermGenie]
synonym: "down regulation of intrinsic apoptotic signaling pathway in response to DNA damage" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA damage response, signal transduction resulting in induction of apoptosis" RELATED [GOC:TermGenie]
synonym: "down-regulation of intrinsic apoptotic signaling pathway in response to DNA damage" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA damage response, signal transduction resulting in induction of apoptosis" RELATED [GOC:TermGenie]
synonym: "downregulation of intrinsic apoptotic signaling pathway in response to DNA damage" EXACT [GOC:TermGenie]
synonym: "inhibition of DNA damage response, signal transduction resulting in induction of apoptosis" RELATED [GOC:TermGenie]
synonym: "inhibition of intrinsic apoptotic signaling pathway in response to DNA damage" NARROW [GOC:TermGenie]
synonym: "negative regulation of DNA damage response, signal transduction resulting in induction of apoptosis" RELATED [GOC:TermGenie]
is_a: GO:1902229 ! regulation of intrinsic apoptotic signaling pathway in response to DNA damage
is_a: GO:2001021 ! negative regulation of response to DNA damage stimulus
is_a: GO:2001243 ! negative regulation of intrinsic apoptotic signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008630 ! intrinsic apoptotic signaling pathway in response to DNA damage
relationship: negatively_regulates GO:0008630 ! intrinsic apoptotic signaling pathway in response to DNA damage
created_by: rl
creation_date: 2013-06-14T09:39:58Z

[Term]
id: GO:1902231
name: positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:15314165]
synonym: "activation of DNA damage response, signal transduction resulting in induction of apoptosis" RELATED [GOC:TermGenie]
synonym: "activation of intrinsic apoptotic signaling pathway in response to DNA damage" NARROW [GOC:TermGenie]
synonym: "positive regulation of DNA damage response, signal transduction resulting in induction of apoptosis" RELATED [GOC:TermGenie]
synonym: "up regulation of DNA damage response, signal transduction resulting in induction of apoptosis" RELATED [GOC:TermGenie]
synonym: "up regulation of intrinsic apoptotic signaling pathway in response to DNA damage" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA damage response, signal transduction resulting in induction of apoptosis" RELATED [GOC:TermGenie]
synonym: "up-regulation of intrinsic apoptotic signaling pathway in response to DNA damage" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA damage response, signal transduction resulting in induction of apoptosis" RELATED [GOC:TermGenie]
synonym: "upregulation of intrinsic apoptotic signaling pathway in response to DNA damage" EXACT [GOC:TermGenie]
is_a: GO:1902229 ! regulation of intrinsic apoptotic signaling pathway in response to DNA damage
is_a: GO:2001022 ! positive regulation of response to DNA damage stimulus
is_a: GO:2001244 ! positive regulation of intrinsic apoptotic signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008630 ! intrinsic apoptotic signaling pathway in response to DNA damage
relationship: positively_regulates GO:0008630 ! intrinsic apoptotic signaling pathway in response to DNA damage
created_by: rl
creation_date: 2013-06-14T09:40:03Z

[Term]
id: GO:1902232
name: regulation of positive thymic T cell selection
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of positive thymic T cell selection." [GOC:TermGenie, PMID:22080863]
synonym: "regulation of positive thymic T lymphocyte selection" EXACT [GOC:TermGenie]
synonym: "regulation of positive thymic T-cell selection" EXACT [GOC:TermGenie]
synonym: "regulation of positive thymic T-lymphocyte selection" EXACT [GOC:TermGenie]
is_a: GO:0033081 ! regulation of T cell differentiation in thymus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045059 ! positive thymic T cell selection
relationship: regulates GO:0045059 ! positive thymic T cell selection
created_by: lb
creation_date: 2013-06-14T11:19:09Z

[Term]
id: GO:1902233
name: negative regulation of positive thymic T cell selection
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of positive thymic T cell selection." [GOC:TermGenie, PMID:22080863]
synonym: "down regulation of positive thymic T cell selection" EXACT [GOC:TermGenie]
synonym: "down regulation of positive thymic T lymphocyte selection" EXACT [GOC:TermGenie]
synonym: "down regulation of positive thymic T-cell selection" EXACT [GOC:TermGenie]
synonym: "down regulation of positive thymic T-lymphocyte selection" EXACT [GOC:TermGenie]
synonym: "down-regulation of positive thymic T cell selection" EXACT [GOC:TermGenie]
synonym: "down-regulation of positive thymic T lymphocyte selection" EXACT [GOC:TermGenie]
synonym: "down-regulation of positive thymic T-cell selection" EXACT [GOC:TermGenie]
synonym: "down-regulation of positive thymic T-lymphocyte selection" EXACT [GOC:TermGenie]
synonym: "downregulation of positive thymic T cell selection" EXACT [GOC:TermGenie]
synonym: "downregulation of positive thymic T lymphocyte selection" EXACT [GOC:TermGenie]
synonym: "downregulation of positive thymic T-cell selection" EXACT [GOC:TermGenie]
synonym: "downregulation of positive thymic T-lymphocyte selection" EXACT [GOC:TermGenie]
synonym: "inhibition of positive thymic T cell selection" NARROW [GOC:TermGenie]
synonym: "inhibition of positive thymic T lymphocyte selection" NARROW [GOC:TermGenie]
synonym: "inhibition of positive thymic T-cell selection" NARROW [GOC:TermGenie]
synonym: "inhibition of positive thymic T-lymphocyte selection" NARROW [GOC:TermGenie]
synonym: "negative regulation of positive thymic T lymphocyte selection" EXACT [GOC:TermGenie]
synonym: "negative regulation of positive thymic T-cell selection" EXACT [GOC:TermGenie]
synonym: "negative regulation of positive thymic T-lymphocyte selection" EXACT [GOC:TermGenie]
is_a: GO:0033085 ! negative regulation of T cell differentiation in thymus
is_a: GO:1902232 ! regulation of positive thymic T cell selection
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045059 ! positive thymic T cell selection
relationship: negatively_regulates GO:0045059 ! positive thymic T cell selection
created_by: lb
creation_date: 2013-06-14T11:19:15Z

[Term]
id: GO:1902234
name: positive regulation of positive thymic T cell selection
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of positive thymic T cell selection." [GOC:TermGenie, PMID:22080863]
synonym: "activation of positive thymic T cell selection" NARROW [GOC:TermGenie]
synonym: "activation of positive thymic T lymphocyte selection" NARROW [GOC:TermGenie]
synonym: "activation of positive thymic T-cell selection" NARROW [GOC:TermGenie]
synonym: "activation of positive thymic T-lymphocyte selection" NARROW [GOC:TermGenie]
synonym: "positive regulation of positive thymic T lymphocyte selection" EXACT [GOC:TermGenie]
synonym: "positive regulation of positive thymic T-cell selection" EXACT [GOC:TermGenie]
synonym: "positive regulation of positive thymic T-lymphocyte selection" EXACT [GOC:TermGenie]
synonym: "up regulation of positive thymic T cell selection" EXACT [GOC:TermGenie]
synonym: "up regulation of positive thymic T lymphocyte selection" EXACT [GOC:TermGenie]
synonym: "up regulation of positive thymic T-cell selection" EXACT [GOC:TermGenie]
synonym: "up regulation of positive thymic T-lymphocyte selection" EXACT [GOC:TermGenie]
synonym: "up-regulation of positive thymic T cell selection" EXACT [GOC:TermGenie]
synonym: "up-regulation of positive thymic T lymphocyte selection" EXACT [GOC:TermGenie]
synonym: "up-regulation of positive thymic T-cell selection" EXACT [GOC:TermGenie]
synonym: "up-regulation of positive thymic T-lymphocyte selection" EXACT [GOC:TermGenie]
synonym: "upregulation of positive thymic T cell selection" EXACT [GOC:TermGenie]
synonym: "upregulation of positive thymic T lymphocyte selection" EXACT [GOC:TermGenie]
synonym: "upregulation of positive thymic T-cell selection" EXACT [GOC:TermGenie]
synonym: "upregulation of positive thymic T-lymphocyte selection" EXACT [GOC:TermGenie]
is_a: GO:0033089 ! positive regulation of T cell differentiation in thymus
is_a: GO:1902232 ! regulation of positive thymic T cell selection
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045059 ! positive thymic T cell selection
relationship: positively_regulates GO:0045059 ! positive thymic T cell selection
created_by: lb
creation_date: 2013-06-14T11:19:20Z

[Term]
id: GO:1902235
name: regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:20160352]
synonym: "regulation of apoptosis in response to endoplasmic reticulum stress" BROAD [GOC:TermGenie]
synonym: "regulation of apoptosis in response to ER stress" EXACT [GOC:TermGenie]
synonym: "regulation of apoptosis triggered by ER stress" EXACT [GOC:TermGenie]
synonym: "regulation of endoplasmic reticulum stress-induced apoptosis" EXACT [GOC:TermGenie]
synonym: "regulation of ER stress-induced apoptosis" EXACT [GOC:TermGenie]
synonym: "regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT [GOC:bf]
synonym: "regulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress" EXACT [GOC:TermGenie]
is_a: GO:0080135 ! regulation of cellular response to stress
is_a: GO:2001242 ! regulation of intrinsic apoptotic signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070059 ! intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
relationship: regulates GO:0070059 ! intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
created_by: rl
creation_date: 2013-06-18T15:19:37Z

[Term]
id: GO:1902236
name: negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:20160352]
synonym: "down regulation of apoptosis in response to ER stress" EXACT [GOC:TermGenie]
synonym: "down regulation of apoptosis triggered by ER stress" EXACT [GOC:TermGenie]
synonym: "down regulation of endoplasmic reticulum stress-induced apoptosis" EXACT [GOC:TermGenie]
synonym: "down regulation of ER stress-induced apoptosis" EXACT [GOC:TermGenie]
synonym: "down regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "down regulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptosis in response to ER stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptosis triggered by ER stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of endoplasmic reticulum stress-induced apoptosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of ER stress-induced apoptosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptosis in response to ER stress" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptosis triggered by ER stress" EXACT [GOC:TermGenie]
synonym: "downregulation of endoplasmic reticulum stress-induced apoptosis" EXACT [GOC:TermGenie]
synonym: "downregulation of ER stress-induced apoptosis" EXACT [GOC:TermGenie]
synonym: "downregulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "downregulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "inhibition of apoptosis in response to ER stress" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptosis triggered by ER stress" NARROW [GOC:TermGenie]
synonym: "inhibition of endoplasmic reticulum stress-induced apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of ER stress-induced apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" NARROW [GOC:TermGenie]
synonym: "inhibition of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptosis in response to ER stress" EXACT [GOC:TermGenie]
synonym: "negative regulation of apoptosis triggered by ER stress" EXACT [GOC:TermGenie]
synonym: "negative regulation of endoplasmic reticulum stress-induced apoptosis" EXACT [GOC:TermGenie]
synonym: "negative regulation of ER stress-induced apoptosis" EXACT [GOC:TermGenie]
synonym: "negative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT [GOC:bf]
synonym: "negative regulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress" EXACT [GOC:TermGenie]
is_a: GO:1902235 ! regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
is_a: GO:1903573 ! negative regulation of response to endoplasmic reticulum stress
is_a: GO:2001243 ! negative regulation of intrinsic apoptotic signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070059 ! intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
relationship: negatively_regulates GO:0070059 ! intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
created_by: rl
creation_date: 2013-06-18T15:19:43Z

[Term]
id: GO:1902237
name: positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:20160352]
synonym: "activation of apoptosis in response to ER stress" NARROW [GOC:TermGenie]
synonym: "activation of apoptosis triggered by ER stress" NARROW [GOC:TermGenie]
synonym: "activation of endoplasmic reticulum stress-induced apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of ER stress-induced apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" NARROW [GOC:TermGenie]
synonym: "activation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptosis in response to ER stress" EXACT [GOC:TermGenie]
synonym: "positive regulation of apoptosis triggered by ER stress" EXACT [GOC:TermGenie]
synonym: "positive regulation of endoplasmic reticulum stress-induced apoptosis" EXACT [GOC:TermGenie]
synonym: "positive regulation of ER stress-induced apoptosis" EXACT [GOC:TermGenie]
synonym: "positive regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT [GOC:bf]
synonym: "positive regulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptosis in response to ER stress" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptosis triggered by ER stress" EXACT [GOC:TermGenie]
synonym: "up regulation of endoplasmic reticulum stress-induced apoptosis" EXACT [GOC:TermGenie]
synonym: "up regulation of ER stress-induced apoptosis" EXACT [GOC:TermGenie]
synonym: "up regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "up regulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptosis in response to ER stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptosis triggered by ER stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of endoplasmic reticulum stress-induced apoptosis" EXACT [GOC:TermGenie]
synonym: "up-regulation of ER stress-induced apoptosis" EXACT [GOC:TermGenie]
synonym: "up-regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptosis in response to ER stress" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptosis triggered by ER stress" EXACT [GOC:TermGenie]
synonym: "upregulation of endoplasmic reticulum stress-induced apoptosis" EXACT [GOC:TermGenie]
synonym: "upregulation of ER stress-induced apoptosis" EXACT [GOC:TermGenie]
synonym: "upregulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "upregulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress" EXACT [GOC:TermGenie]
is_a: GO:1902235 ! regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
is_a: GO:2001244 ! positive regulation of intrinsic apoptotic signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070059 ! intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
relationship: positively_regulates GO:0070059 ! intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
created_by: rl
creation_date: 2013-06-18T15:19:49Z

[Term]
id: GO:1902238
name: regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator." [GOC:krc, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16571598]
is_a: GO:1902218 ! regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
is_a: GO:1902253 ! regulation of intrinsic apoptotic signaling pathway by p53 class mediator
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990127 ! intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator
relationship: regulates GO:1990127 ! intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator
created_by: pr
creation_date: 2013-06-19T14:00:34Z

[Term]
id: GO:1902239
name: negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator." [GOC:krc, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16571598]
synonym: "down regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "down-regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "downregulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "inhibition of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator" NARROW [GOC:TermGenie]
is_a: GO:1902219 ! negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
is_a: GO:1902238 ! regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator
is_a: GO:1902254 ! negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990127 ! intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator
relationship: negatively_regulates GO:1990127 ! intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator
created_by: pr
creation_date: 2013-06-19T14:00:39Z

[Term]
id: GO:1902240
name: positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator." [GOC:krc, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16571598]
synonym: "activation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator" NARROW [GOC:TermGenie]
synonym: "up regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "up-regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "upregulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator" EXACT [GOC:TermGenie]
is_a: GO:1902220 ! positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
is_a: GO:1902238 ! regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator
is_a: GO:1902255 ! positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990127 ! intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator
relationship: positively_regulates GO:1990127 ! intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator
created_by: pr
creation_date: 2013-06-19T14:00:44Z

[Term]
id: GO:1902241
name: copal-8-ol diphosphate(3-) metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving copal-8-ol diphosphate(3-)." [GOC:TermGenie, pmid:22672125]
synonym: "copal-8-ol diphosphate(3-) metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006644 ! phospholipid metabolic process
is_a: GO:0016101 ! diterpenoid metabolic process
created_by: ms
creation_date: 2013-06-20T09:09:27Z

[Term]
id: GO:1902242
name: copal-8-ol diphosphate(3-) catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of copal-8-ol diphosphate(3-)." [GOC:TermGenie, pmid:22672125]
synonym: "copal-8-ol diphosphate(3-) breakdown" EXACT [GOC:TermGenie]
synonym: "copal-8-ol diphosphate(3-) catabolism" EXACT [GOC:TermGenie]
synonym: "copal-8-ol diphosphate(3-) degradation" EXACT [GOC:TermGenie]
is_a: GO:0009395 ! phospholipid catabolic process
is_a: GO:0016103 ! diterpenoid catabolic process
is_a: GO:1902241 ! copal-8-ol diphosphate(3-) metabolic process
created_by: ms
creation_date: 2013-06-20T09:09:33Z

[Term]
id: GO:1902243
name: copal-8-ol diphosphate(3-) biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of copal-8-ol diphosphate(3-)." [GOC:TermGenie, pmid:22672125]
synonym: "copal-8-ol diphosphate(3-) anabolism" EXACT [GOC:TermGenie]
synonym: "copal-8-ol diphosphate(3-) biosynthesis" EXACT [GOC:TermGenie]
synonym: "copal-8-ol diphosphate(3-) formation" EXACT [GOC:TermGenie]
synonym: "copal-8-ol diphosphate(3-) synthesis" EXACT [GOC:TermGenie]
is_a: GO:0008654 ! phospholipid biosynthetic process
is_a: GO:0016102 ! diterpenoid biosynthetic process
is_a: GO:1902241 ! copal-8-ol diphosphate(3-) metabolic process
created_by: ms
creation_date: 2013-06-20T09:09:38Z

[Term]
id: GO:1902244
name: cis-abienol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cis-abienol." [GOC:TermGenie, pmid:22672125]
synonym: "cis-abienol metabolism" EXACT [GOC:TermGenie]
is_a: GO:0016101 ! diterpenoid metabolic process
is_a: GO:1902644 ! tertiary alcohol metabolic process
created_by: ms
creation_date: 2013-06-20T09:09:51Z

[Term]
id: GO:1902245
name: cis-abienol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cis-abienol." [GOC:TermGenie, pmid:22672125]
synonym: "cis-abienol breakdown" EXACT [GOC:TermGenie]
synonym: "cis-abienol catabolism" EXACT [GOC:TermGenie]
synonym: "cis-abienol degradation" EXACT [GOC:TermGenie]
is_a: GO:0016103 ! diterpenoid catabolic process
is_a: GO:0046164 ! alcohol catabolic process
is_a: GO:1902244 ! cis-abienol metabolic process
created_by: ms
creation_date: 2013-06-20T09:09:57Z

[Term]
id: GO:1902246
name: cis-abienol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cis-abienol." [GOC:TermGenie, pmid:22672125]
synonym: "cis-abienol anabolism" EXACT [GOC:TermGenie]
synonym: "cis-abienol biosynthesis" EXACT [GOC:TermGenie]
synonym: "cis-abienol formation" EXACT [GOC:TermGenie]
synonym: "cis-abienol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0016102 ! diterpenoid biosynthetic process
is_a: GO:1902244 ! cis-abienol metabolic process
is_a: GO:1902645 ! tertiary alcohol biosynthetic process
created_by: ms
creation_date: 2013-06-20T09:10:02Z

[Term]
id: GO:1902247
name: geranylgeranyl diphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of geranylgeranyl diphosphate." [GOC:TermGenie, pmid:22672125]
synonym: "geranylgeranyl diphosphate breakdown" EXACT [GOC:TermGenie]
synonym: "geranylgeranyl diphosphate catabolism" EXACT [GOC:TermGenie]
synonym: "geranylgeranyl diphosphate degradation" EXACT [GOC:TermGenie]
is_a: GO:0009395 ! phospholipid catabolic process
is_a: GO:0016115 ! terpenoid catabolic process
is_a: GO:0033385 ! geranylgeranyl diphosphate metabolic process
created_by: ms
creation_date: 2013-06-20T09:10:09Z

[Term]
id: GO:1902248
name: 5-O-phosphono-alpha-D-ribofuranosyl diphosphate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with 5-O-phosphono-alpha-D-ribofuranosyl diphosphate." [GOC:mah, GOC:TermGenie, PMID:4314233]
synonym: "5-phosphoribose 1-diphosphate binding" EXACT [GOC:curators]
synonym: "phosphoribosylpyrophosphate binding" EXACT [GOC:al]
is_a: GO:0043168 ! anion binding
is_a: GO:0097367 ! carbohydrate derivative binding
created_by: mah
creation_date: 2013-06-20T16:20:29Z

[Term]
id: GO:1902249
name: IMP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with IMP, inosine monophosphate." [GOC:mah, GOC:TermGenie, PMID:4314233]
is_a: GO:0032555 ! purine ribonucleotide binding
is_a: GO:0043168 ! anion binding
created_by: mah
creation_date: 2013-06-20T16:20:35Z

[Term]
id: GO:1902250
name: regulation of erythrocyte apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of erythrocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084]
synonym: "regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of RBC apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of RBC apoptotic process" EXACT [GOC:TermGenie]
synonym: "regulation of red blood cell apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0033032 ! regulation of myeloid cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1902217 ! erythrocyte apoptotic process
relationship: regulates GO:1902217 ! erythrocyte apoptotic process
created_by: rl
creation_date: 2013-06-20T19:30:53Z

[Term]
id: GO:1902251
name: negative regulation of erythrocyte apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of erythrocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084]
synonym: "down regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "down regulation of RBC apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of RBC apoptotic process" EXACT [GOC:TermGenie]
synonym: "down regulation of red blood cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of RBC apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of RBC apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of red blood cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of erythrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of RBC apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of RBC apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of red blood cell apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of red blood cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "inhibition of erythrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of erythrocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "inhibition of RBC apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of RBC apoptotic process" NARROW [GOC:TermGenie]
synonym: "inhibition of red blood cell apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of red blood cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of RBC apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of RBC apoptotic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of red blood cell apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0033033 ! negative regulation of myeloid cell apoptotic process
is_a: GO:1902250 ! regulation of erythrocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1902217 ! erythrocyte apoptotic process
relationship: negatively_regulates GO:1902217 ! erythrocyte apoptotic process
created_by: rl
creation_date: 2013-06-20T19:30:59Z

[Term]
id: GO:1902252
name: positive regulation of erythrocyte apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of erythrocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084]
synonym: "activation of erythrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of erythrocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "activation of RBC apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of RBC apoptotic process" NARROW [GOC:TermGenie]
synonym: "activation of red blood cell apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of red blood cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of RBC apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of RBC apoptotic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of red blood cell apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of RBC apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of RBC apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of red blood cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of RBC apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of RBC apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of red blood cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of erythrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of RBC apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of RBC apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of red blood cell apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of red blood cell apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0033034 ! positive regulation of myeloid cell apoptotic process
is_a: GO:1902250 ! regulation of erythrocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1902217 ! erythrocyte apoptotic process
relationship: positively_regulates GO:1902217 ! erythrocyte apoptotic process
created_by: rl
creation_date: 2013-06-20T19:31:04Z

[Term]
id: GO:1902253
name: regulation of intrinsic apoptotic signaling pathway by p53 class mediator
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway by p53 class mediator." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:15705871]
synonym: "regulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "regulation of signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie]
is_a: GO:1901796 ! regulation of signal transduction by p53 class mediator
is_a: GO:2001242 ! regulation of intrinsic apoptotic signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072332 ! intrinsic apoptotic signaling pathway by p53 class mediator
relationship: regulates GO:0072332 ! intrinsic apoptotic signaling pathway by p53 class mediator
created_by: rl
creation_date: 2013-06-20T19:41:38Z

[Term]
id: GO:1902254
name: negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway by p53 class mediator." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:15705871]
synonym: "down regulation of intrinsic apoptotic signaling pathway by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "down regulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "down regulation of signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie]
synonym: "down-regulation of intrinsic apoptotic signaling pathway by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "down-regulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "down-regulation of signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie]
synonym: "downregulation of intrinsic apoptotic signaling pathway by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "downregulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "downregulation of signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie]
synonym: "inhibition of intrinsic apoptotic signaling pathway by p53 class mediator" NARROW [GOC:TermGenie]
synonym: "inhibition of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator" NARROW [GOC:TermGenie]
synonym: "inhibition of signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie]
synonym: "negative regulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "negative regulation of signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie]
is_a: GO:1901797 ! negative regulation of signal transduction by p53 class mediator
is_a: GO:1902253 ! regulation of intrinsic apoptotic signaling pathway by p53 class mediator
is_a: GO:2001243 ! negative regulation of intrinsic apoptotic signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072332 ! intrinsic apoptotic signaling pathway by p53 class mediator
relationship: negatively_regulates GO:0072332 ! intrinsic apoptotic signaling pathway by p53 class mediator
created_by: rl
creation_date: 2013-06-20T19:41:43Z

[Term]
id: GO:1902255
name: positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway by p53 class mediator." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:15705871]
synonym: "activation of intrinsic apoptotic signaling pathway by p53 class mediator" NARROW [GOC:TermGenie]
synonym: "activation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator" NARROW [GOC:TermGenie]
synonym: "activation of signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie]
synonym: "positive regulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "positive regulation of signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie]
synonym: "up regulation of intrinsic apoptotic signaling pathway by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "up regulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "up regulation of signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie]
synonym: "up-regulation of intrinsic apoptotic signaling pathway by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "up-regulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "up-regulation of signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie]
synonym: "upregulation of intrinsic apoptotic signaling pathway by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "upregulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator" EXACT [GOC:TermGenie]
synonym: "upregulation of signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie]
is_a: GO:1901798 ! positive regulation of signal transduction by p53 class mediator
is_a: GO:1902253 ! regulation of intrinsic apoptotic signaling pathway by p53 class mediator
is_a: GO:2001244 ! positive regulation of intrinsic apoptotic signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072332 ! intrinsic apoptotic signaling pathway by p53 class mediator
relationship: positively_regulates GO:0072332 ! intrinsic apoptotic signaling pathway by p53 class mediator
created_by: rl
creation_date: 2013-06-20T19:41:54Z

[Term]
id: GO:1902256
name: regulation of apoptotic process involved in outflow tract morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis." [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16839542]
synonym: "regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
is_a: GO:1902337 ! regulation of apoptotic process involved in morphogenesis
is_a: GO:2000826 ! regulation of heart morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003275 ! apoptotic process involved in outflow tract morphogenesis
relationship: regulates GO:0003275 ! apoptotic process involved in outflow tract morphogenesis
created_by: dph
creation_date: 2013-06-24T19:12:24Z

[Term]
id: GO:1902257
name: negative regulation of apoptotic process involved in outflow tract morphogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis." [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16839542]
synonym: "down regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
synonym: "down regulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic process involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1902256 ! regulation of apoptotic process involved in outflow tract morphogenesis
is_a: GO:1902338 ! negative regulation of apoptotic process involved in morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003275 ! apoptotic process involved in outflow tract morphogenesis
relationship: negatively_regulates GO:0003275 ! apoptotic process involved in outflow tract morphogenesis
created_by: dph
creation_date: 2013-06-24T19:12:30Z

[Term]
id: GO:1902258
name: positive regulation of apoptotic process involved in outflow tract morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis." [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16839542]
synonym: "activation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic process involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1902256 ! regulation of apoptotic process involved in outflow tract morphogenesis
is_a: GO:1902339 ! positive regulation of apoptotic process involved in morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003275 ! apoptotic process involved in outflow tract morphogenesis
relationship: positively_regulates GO:0003275 ! apoptotic process involved in outflow tract morphogenesis
created_by: dph
creation_date: 2013-06-24T19:12:42Z

[Term]
id: GO:1902259
name: regulation of delayed rectifier potassium channel activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of delayed rectifier potassium channel activity." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11299204]
is_a: GO:1901016 ! regulation of potassium ion transmembrane transporter activity
is_a: GO:2001257 ! regulation of cation channel activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0005251 ! delayed rectifier potassium channel activity
relationship: regulates GO:0005251 ! delayed rectifier potassium channel activity
created_by: rl
creation_date: 2013-06-25T12:16:19Z

[Term]
id: GO:1902260
name: negative regulation of delayed rectifier potassium channel activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of delayed rectifier potassium channel activity." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:11299204]
synonym: "down regulation of delayed rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of delayed rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of delayed rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "inhibition of delayed rectifier potassium channel activity" NARROW [GOC:TermGenie]
is_a: GO:1902259 ! regulation of delayed rectifier potassium channel activity
is_a: GO:1903817 ! negative regulation of voltage-gated potassium channel activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0005251 ! delayed rectifier potassium channel activity
relationship: negatively_regulates GO:0005251 ! delayed rectifier potassium channel activity
created_by: rl
creation_date: 2013-06-25T12:16:24Z

[Term]
id: GO:1902261
name: positive regulation of delayed rectifier potassium channel activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of delayed rectifier potassium channel activity." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11299204]
synonym: "activation of delayed rectifier potassium channel activity" NARROW [GOC:TermGenie]
synonym: "up regulation of delayed rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of delayed rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of delayed rectifier potassium channel activity" EXACT [GOC:TermGenie]
is_a: GO:1902259 ! regulation of delayed rectifier potassium channel activity
is_a: GO:1903818 ! positive regulation of voltage-gated potassium channel activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0005251 ! delayed rectifier potassium channel activity
relationship: positively_regulates GO:0005251 ! delayed rectifier potassium channel activity
created_by: rl
creation_date: 2013-06-25T12:16:30Z

[Term]
id: GO:1902262
name: apoptotic process involved in patterning of blood vessels
namespace: biological_process
def: "Any apoptotic process that is involved in patterning of blood vessels." [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16163358]
synonym: "apoptosis involved in patterning of blood vessels" NARROW [GOC:TermGenie]
synonym: "apoptotic cell death involved in patterning of blood vessels" EXACT [GOC:TermGenie]
synonym: "apoptotic program involved in patterning of blood vessels" NARROW [GOC:TermGenie]
synonym: "apoptotic programmed cell death involved in patterning of blood vessels" EXACT [GOC:TermGenie]
synonym: "programmed cell death by apoptosis involved in patterning of blood vessels" EXACT [GOC:TermGenie]
synonym: "signaling (initiator) caspase activity involved in patterning of blood vessels" RELATED [GOC:TermGenie]
synonym: "type I programmed cell death involved in patterning of blood vessels" NARROW [GOC:TermGenie]
is_a: GO:0060561 ! apoptotic process involved in morphogenesis
intersection_of: GO:0006915 ! apoptotic process
intersection_of: part_of GO:0001569 ! patterning of blood vessels
relationship: part_of GO:0001569 ! patterning of blood vessels
created_by: dph
creation_date: 2013-06-25T16:16:00Z

[Term]
id: GO:1902263
name: apoptotic process involved in embryonic digit morphogenesis
namespace: biological_process
def: "Any apoptotic process that is involved in embryonic digit morphogenesis." [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:15967824]
synonym: "apoptosis involved in embryonic digit morphogenesis" NARROW [GOC:TermGenie]
synonym: "apoptotic cell death involved in embryonic digit morphogenesis" EXACT [GOC:TermGenie]
synonym: "apoptotic program involved in embryonic digit morphogenesis" NARROW [GOC:TermGenie]
synonym: "apoptotic programmed cell death involved in embryonic digit morphogenesis" EXACT [GOC:TermGenie]
synonym: "programmed cell death by apoptosis involved in embryonic digit morphogenesis" EXACT [GOC:TermGenie]
synonym: "signaling (initiator) caspase activity involved in embryonic digit morphogenesis" RELATED [GOC:TermGenie]
synonym: "type I programmed cell death involved in embryonic digit morphogenesis" NARROW [GOC:TermGenie]
is_a: GO:0060561 ! apoptotic process involved in morphogenesis
intersection_of: GO:0006915 ! apoptotic process
intersection_of: part_of GO:0042733 ! embryonic digit morphogenesis
relationship: part_of GO:0042733 ! embryonic digit morphogenesis
created_by: dph
creation_date: 2013-06-25T16:19:22Z

[Term]
id: GO:1902265
name: abscisic acid homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of abscisic acid within an organism or cell." [GOC:TermGenie, PMID:23252460]
synonym: "2-cis-abscisate homeostasis" RELATED []
synonym: "ABA homeostasis" RELATED []
is_a: GO:0055081 ! anion homeostasis
is_a: GO:0055088 ! lipid homeostasis
created_by: tb
creation_date: 2013-06-27T21:05:30Z

[Term]
id: GO:1902266
name: cellular abscisic acid homeostasis
namespace: biological_process
def: "Any biological process involved in the maintenance of an internal steady state of abscisic acid at the level of the cell." [GOC:TermGenie, PMID:23252460]
synonym: "cellular 2-cis-abscisate homeostasis" EXACT []
synonym: "cellular ABA homeostasis" RELATED []
is_a: GO:0030002 ! cellular anion homeostasis
is_a: GO:1902265 ! abscisic acid homeostasis
created_by: tb
creation_date: 2013-06-27T21:05:36Z

[Term]
id: GO:1902267
name: regulation of polyamine transmembrane transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of polyamine transmembrane transport." [GOC:TermGenie, PMID:23755272]
is_a: GO:0034762 ! regulation of transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1902047 ! polyamine transmembrane transport
relationship: regulates GO:1902047 ! polyamine transmembrane transport
created_by: mcc
creation_date: 2013-06-28T21:34:36Z

[Term]
id: GO:1902268
name: negative regulation of polyamine transmembrane transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of polyamine transmembrane transport." [GOC:TermGenie, PMID:23755272]
synonym: "down regulation of polyamine transmembrane transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of polyamine transmembrane transport" EXACT [GOC:TermGenie]
synonym: "downregulation of polyamine transmembrane transport" EXACT [GOC:TermGenie]
synonym: "inhibition of polyamine transmembrane transport" NARROW [GOC:TermGenie]
is_a: GO:0034763 ! negative regulation of transmembrane transport
is_a: GO:1902267 ! regulation of polyamine transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1902047 ! polyamine transmembrane transport
relationship: negatively_regulates GO:1902047 ! polyamine transmembrane transport
created_by: mcc
creation_date: 2013-06-28T21:34:42Z

[Term]
id: GO:1902269
name: positive regulation of polyamine transmembrane transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of polyamine transmembrane transport." [GOC:TermGenie, PMID:23755272]
synonym: "activation of polyamine transmembrane transport" NARROW [GOC:TermGenie]
synonym: "up regulation of polyamine transmembrane transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of polyamine transmembrane transport" EXACT [GOC:TermGenie]
synonym: "upregulation of polyamine transmembrane transport" EXACT [GOC:TermGenie]
is_a: GO:0034764 ! positive regulation of transmembrane transport
is_a: GO:1902267 ! regulation of polyamine transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1902047 ! polyamine transmembrane transport
relationship: positively_regulates GO:1902047 ! polyamine transmembrane transport
created_by: mcc
creation_date: 2013-06-28T21:34:47Z

[Term]
id: GO:1902270
name: (R)-carnitine transmembrane transport
namespace: biological_process
def: "The directed movement of (R)-carnitine across a membrane." [GOC:TermGenie, PMID:23755272]
is_a: GO:1900749 ! (R)-carnitine transport
is_a: GO:1902603 ! carnitine transmembrane transport
created_by: mcc
creation_date: 2013-06-28T21:57:39Z

[Term]
id: GO:1902271
name: D3 vitamins binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with D3 vitamins." [GOC:bf, GOC:TermGenie, PMID:9127467]
is_a: GO:0005499 ! vitamin D binding
created_by: bf
creation_date: 2013-07-01T12:54:37Z

[Term]
id: GO:1902272
name: regulation of (R)-carnitine transmembrane transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of (R)-carnitine transmembrane transport." [GOC:TermGenie, PMID:23755272]
is_a: GO:0032890 ! regulation of organic acid transport
is_a: GO:1903795 ! regulation of inorganic anion transmembrane transport
is_a: GO:1904062 ! regulation of cation transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1902270 ! (R)-carnitine transmembrane transport
relationship: regulates GO:1902270 ! (R)-carnitine transmembrane transport
created_by: mcc
creation_date: 2013-07-01T13:13:11Z

[Term]
id: GO:1902273
name: negative regulation of (R)-carnitine transmembrane transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of (R)-carnitine transmembrane transport." [GOC:TermGenie, PMID:23755272]
synonym: "down regulation of (R)-carnitine transmembrane transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of (R)-carnitine transmembrane transport" EXACT [GOC:TermGenie]
synonym: "downregulation of (R)-carnitine transmembrane transport" EXACT [GOC:TermGenie]
synonym: "inhibition of (R)-carnitine transmembrane transport" NARROW [GOC:TermGenie]
is_a: GO:0032891 ! negative regulation of organic acid transport
is_a: GO:1902272 ! regulation of (R)-carnitine transmembrane transport
is_a: GO:1903796 ! negative regulation of inorganic anion transmembrane transport
is_a: GO:1904063 ! negative regulation of cation transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1902270 ! (R)-carnitine transmembrane transport
relationship: negatively_regulates GO:1902270 ! (R)-carnitine transmembrane transport
created_by: mcc
creation_date: 2013-07-01T13:13:17Z

[Term]
id: GO:1902274
name: positive regulation of (R)-carnitine transmembrane transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of (R)-carnitine transmembrane transport." [GOC:TermGenie, PMID:23755272]
synonym: "activation of (R)-carnitine transmembrane transport" NARROW [GOC:TermGenie]
synonym: "up regulation of (R)-carnitine transmembrane transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of (R)-carnitine transmembrane transport" EXACT [GOC:TermGenie]
synonym: "upregulation of (R)-carnitine transmembrane transport" EXACT [GOC:TermGenie]
is_a: GO:0032892 ! positive regulation of organic acid transport
is_a: GO:1902272 ! regulation of (R)-carnitine transmembrane transport
is_a: GO:1903797 ! positive regulation of inorganic anion transmembrane transport
is_a: GO:1904064 ! positive regulation of cation transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1902270 ! (R)-carnitine transmembrane transport
relationship: positively_regulates GO:1902270 ! (R)-carnitine transmembrane transport
created_by: mcc
creation_date: 2013-07-01T13:13:22Z

[Term]
id: GO:1902275
name: regulation of chromatin organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chromatin organization." [GOC:bf, GOC:TermGenie, PMID:18314879]
synonym: "regulation of chromatin organisation" EXACT [GOC:TermGenie]
synonym: "regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie]
is_a: GO:0033044 ! regulation of chromosome organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006325 ! chromatin organization
relationship: regulates GO:0006325 ! chromatin organization
created_by: bf
creation_date: 2013-07-01T13:21:52Z

[Term]
id: GO:1902276
name: regulation of pancreatic amylase secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pancreatic amylase secretion." [GOC:jc, GOC:TermGenie]
is_a: GO:0050708 ! regulation of protein secretion
is_a: GO:0090186 ! regulation of pancreatic juice secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0036395 ! pancreatic amylase secretion
relationship: regulates GO:0036395 ! pancreatic amylase secretion
created_by: bf
creation_date: 2013-07-03T12:15:20Z

[Term]
id: GO:1902277
name: negative regulation of pancreatic amylase secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of pancreatic amylase secretion." [GOC:jc, GOC:TermGenie]
synonym: "down regulation of pancreatic amylase secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of pancreatic amylase secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of pancreatic amylase secretion" EXACT [GOC:TermGenie]
synonym: "inhibition of pancreatic amylase secretion" NARROW [GOC:TermGenie]
is_a: GO:0050709 ! negative regulation of protein secretion
is_a: GO:0090188 ! negative regulation of pancreatic juice secretion
is_a: GO:1902276 ! regulation of pancreatic amylase secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0036395 ! pancreatic amylase secretion
relationship: negatively_regulates GO:0036395 ! pancreatic amylase secretion
created_by: bf
creation_date: 2013-07-03T12:15:26Z

[Term]
id: GO:1902278
name: positive regulation of pancreatic amylase secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pancreatic amylase secretion." [GOC:jc, GOC:TermGenie, PMID:19028687]
synonym: "activation of pancreatic amylase secretion" NARROW [GOC:TermGenie]
synonym: "up regulation of pancreatic amylase secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of pancreatic amylase secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of pancreatic amylase secretion" EXACT [GOC:TermGenie]
is_a: GO:0050714 ! positive regulation of protein secretion
is_a: GO:0090187 ! positive regulation of pancreatic juice secretion
is_a: GO:1902276 ! regulation of pancreatic amylase secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0036395 ! pancreatic amylase secretion
relationship: positively_regulates GO:0036395 ! pancreatic amylase secretion
created_by: bf
creation_date: 2013-07-03T12:15:31Z

[Term]
id: GO:1902279
name: positive regulation of pancreatic amylase secretion by cholecystokinin signaling pathway
namespace: biological_process
def: "A cholecystokinin signaling pathway that results in positive regulation of pancreatic amylase secretion." [GOC:jc, GOC:TermGenie, PMID:19028687]
synonym: "activation of pancreatic amylase secretion by cholecystokinin signaling pathway" NARROW [GOC:TermGenie]
synonym: "CCK-induced amylase release in pancreatic cell" EXACT [PMID:19028687]
synonym: "CCK-mediated pancreatic amylase secretion" EXACT [PMID:19028687]
synonym: "CCK-stimulated pancreatic amylase release" EXACT [PMID:19028687]
synonym: "cholecystokinin-mediated pancreatic amylase secretion" EXACT [PMID:19028687]
synonym: "up regulation of pancreatic amylase secretion by cholecystokinin signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of pancreatic amylase secretion by cholecystokinin signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of pancreatic amylase secretion by cholecystokinin signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0038188 ! cholecystokinin signaling pathway
is_a: GO:1902278 ! positive regulation of pancreatic amylase secretion
intersection_of: GO:0038188 ! cholecystokinin signaling pathway
intersection_of: positively_regulates GO:0036395 ! pancreatic amylase secretion
relationship: positively_regulates GO:0036395 ! pancreatic amylase secretion
created_by: bf
creation_date: 2013-07-03T16:02:40Z

[Term]
id: GO:1902280
name: regulation of ATP-dependent RNA helicase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ATP-dependent RNA helicase activity." [GOC:rb, GOC:TermGenie, PMID:23721653]
is_a: GO:0043462 ! regulation of ATPase activity
is_a: GO:0051095 ! regulation of helicase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004004 ! ATP-dependent RNA helicase activity
relationship: regulates GO:0004004 ! ATP-dependent RNA helicase activity
created_by: rb
creation_date: 2013-07-03T18:05:19Z

[Term]
id: GO:1902281
name: negative regulation of ATP-dependent RNA helicase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ATP-dependent RNA helicase activity." [GOC:rb, GOC:TermGenie, PMID:23721653]
synonym: "down regulation of ATP-dependent RNA helicase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of ATP-dependent RNA helicase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of ATP-dependent RNA helicase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of ATP-dependent RNA helicase activity" NARROW [GOC:TermGenie]
is_a: GO:0032780 ! negative regulation of ATPase activity
is_a: GO:0051097 ! negative regulation of helicase activity
is_a: GO:1902280 ! regulation of ATP-dependent RNA helicase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004004 ! ATP-dependent RNA helicase activity
relationship: negatively_regulates GO:0004004 ! ATP-dependent RNA helicase activity
created_by: rb
creation_date: 2013-07-03T18:05:25Z

[Term]
id: GO:1902282
name: voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
namespace: molecular_function
def: "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a ventricular cardiomyocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:8528244]
synonym: "voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
is_a: GO:0086008 ! voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
relationship: part_of GO:0098915 ! membrane repolarization during ventricular cardiac muscle cell action potential
created_by: rl
creation_date: 2013-07-05T20:12:22Z

[Term]
id: GO:1902283
name: negative regulation of primary amine oxidase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of primary amine oxidase activity." [GOC:TermGenie, PMID:23349812]
synonym: "down regulation of amine oxidase (copper-containing) activity" NARROW [GOC:TermGenie]
synonym: "down regulation of primary amine oxidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of primary-amine:oxygen oxidoreductase (deaminating) activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of amine oxidase (copper-containing) activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of primary amine oxidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of primary-amine:oxygen oxidoreductase (deaminating) activity" EXACT [GOC:TermGenie]
synonym: "downregulation of amine oxidase (copper-containing) activity" NARROW [GOC:TermGenie]
synonym: "downregulation of primary amine oxidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of primary-amine:oxygen oxidoreductase (deaminating) activity" EXACT [GOC:TermGenie]
synonym: "inhibition of amine oxidase (copper-containing) activity" NARROW [GOC:TermGenie]
synonym: "inhibition of primary amine oxidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of primary-amine:oxygen oxidoreductase (deaminating) activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of amine oxidase (copper-containing) activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of primary-amine:oxygen oxidoreductase (deaminating) activity" EXACT [GOC:TermGenie]
is_a: GO:0051354 ! negative regulation of oxidoreductase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008131 ! primary amine oxidase activity
relationship: negatively_regulates GO:0008131 ! primary amine oxidase activity
created_by: ecu
creation_date: 2013-07-08T13:27:59Z

[Term]
id: GO:1902284
name: neuron projection extension involved in neuron projection guidance
namespace: biological_process
def: "Any neuron projection extension that is involved in neuron projection guidance." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22790009]
synonym: "neurite extension involved in neurite guidance" NARROW [GOC:TermGenie]
synonym: "neurite extension involved in neuron process guidance" NARROW [GOC:TermGenie]
synonym: "neurite extension involved in neuron projection guidance" NARROW [GOC:TermGenie]
synonym: "neurite extension involved in neuron protrusion guidance" NARROW [GOC:TermGenie]
synonym: "neurite extension involved in neuronal cell projection guidance" NARROW [GOC:TermGenie]
synonym: "neuron process extension involved in neurite guidance" NARROW [GOC:TermGenie]
synonym: "neuron process extension involved in neuron process guidance" EXACT [GOC:TermGenie]
synonym: "neuron process extension involved in neuron projection guidance" EXACT [GOC:TermGenie]
synonym: "neuron process extension involved in neuron protrusion guidance" EXACT [GOC:TermGenie]
synonym: "neuron process extension involved in neuronal cell projection guidance" EXACT [GOC:TermGenie]
synonym: "neuron projection extension involved in neurite guidance" NARROW [GOC:TermGenie]
synonym: "neuron projection extension involved in neuron process guidance" EXACT [GOC:TermGenie]
synonym: "neuron projection extension involved in neuron protrusion guidance" EXACT [GOC:TermGenie]
synonym: "neuron projection extension involved in neuronal cell projection guidance" EXACT [GOC:TermGenie]
synonym: "neuron protrusion extension involved in neurite guidance" NARROW [GOC:TermGenie]
synonym: "neuron protrusion extension involved in neuron process guidance" EXACT [GOC:TermGenie]
synonym: "neuron protrusion extension involved in neuron projection guidance" EXACT [GOC:TermGenie]
synonym: "neuron protrusion extension involved in neuron protrusion guidance" EXACT [GOC:TermGenie]
synonym: "neuron protrusion extension involved in neuronal cell projection guidance" EXACT [GOC:TermGenie]
synonym: "neuronal cell projection extension involved in neurite guidance" NARROW [GOC:TermGenie]
synonym: "neuronal cell projection extension involved in neuron process guidance" EXACT [GOC:TermGenie]
synonym: "neuronal cell projection extension involved in neuron projection guidance" EXACT [GOC:TermGenie]
synonym: "neuronal cell projection extension involved in neuron protrusion guidance" EXACT [GOC:TermGenie]
synonym: "neuronal cell projection extension involved in neuronal cell projection guidance" EXACT [GOC:TermGenie]
is_a: GO:1990138 ! neuron projection extension
intersection_of: GO:1990138 ! neuron projection extension
intersection_of: part_of GO:0097485 ! neuron projection guidance
relationship: part_of GO:0097485 ! neuron projection guidance
created_by: pr
creation_date: 2013-07-08T15:55:17Z

[Term]
id: GO:1902285
name: semaphorin-plexin signaling pathway involved in neuron projection guidance
namespace: biological_process
def: "Any semaphorin-plexin signaling pathway that is involved in neuron projection guidance." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22790009]
synonym: "semaphorin-plexin signaling pathway involved in neurite guidance" NARROW [GOC:TermGenie]
synonym: "semaphorin-plexin signaling pathway involved in neuron process guidance" EXACT [GOC:TermGenie]
synonym: "semaphorin-plexin signaling pathway involved in neuron protrusion guidance" EXACT [GOC:TermGenie]
synonym: "semaphorin-plexin signaling pathway involved in neuronal cell projection guidance" EXACT [GOC:TermGenie]
synonym: "semaphorin-plexin signalling pathway involved in neurite guidance" NARROW [GOC:TermGenie]
synonym: "semaphorin-plexin signalling pathway involved in neuron process guidance" EXACT [GOC:TermGenie]
synonym: "semaphorin-plexin signalling pathway involved in neuron projection guidance" EXACT [GOC:TermGenie]
synonym: "semaphorin-plexin signalling pathway involved in neuron protrusion guidance" EXACT [GOC:TermGenie]
synonym: "semaphorin-plexin signalling pathway involved in neuronal cell projection guidance" EXACT [GOC:TermGenie]
is_a: GO:0071526 ! semaphorin-plexin signaling pathway
intersection_of: GO:0071526 ! semaphorin-plexin signaling pathway
intersection_of: part_of GO:0097485 ! neuron projection guidance
relationship: part_of GO:0097485 ! neuron projection guidance
created_by: pr
creation_date: 2013-07-08T16:06:46Z

[Term]
id: GO:1902286
name: semaphorin-plexin signaling pathway involved in dendrite guidance
namespace: biological_process
def: "Any semaphorin-plexin signaling pathway that is involved in dendrite guidance." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22790009]
synonym: "semaphorin-plexin signaling pathway involved in dendritic guidance" EXACT [GOC:TermGenie]
synonym: "semaphorin-plexin signalling pathway involved in dendrite guidance" EXACT [GOC:TermGenie]
synonym: "semaphorin-plexin signalling pathway involved in dendritic guidance" EXACT [GOC:TermGenie]
is_a: GO:1902285 ! semaphorin-plexin signaling pathway involved in neuron projection guidance
intersection_of: GO:0071526 ! semaphorin-plexin signaling pathway
intersection_of: part_of GO:0070983 ! dendrite guidance
relationship: part_of GO:0070983 ! dendrite guidance
created_by: pr
creation_date: 2013-07-08T16:06:55Z

[Term]
id: GO:1902287
name: semaphorin-plexin signaling pathway involved in axon guidance
namespace: biological_process
def: "Any semaphorin-plexin signaling pathway that is involved in axon guidance." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22790009]
synonym: "semaphorin-plexin signaling pathway involved in axon chemotaxis" RELATED [GOC:TermGenie]
synonym: "semaphorin-plexin signaling pathway involved in axon growth cone guidance" NARROW [GOC:TermGenie]
synonym: "semaphorin-plexin signaling pathway involved in axon pathfinding" EXACT [GOC:TermGenie]
synonym: "semaphorin-plexin signalling pathway involved in axon chemotaxis" RELATED [GOC:TermGenie]
synonym: "semaphorin-plexin signalling pathway involved in axon growth cone guidance" NARROW [GOC:TermGenie]
synonym: "semaphorin-plexin signalling pathway involved in axon guidance" EXACT [GOC:TermGenie]
synonym: "semaphorin-plexin signalling pathway involved in axon pathfinding" EXACT [GOC:TermGenie]
is_a: GO:1902285 ! semaphorin-plexin signaling pathway involved in neuron projection guidance
intersection_of: GO:0071526 ! semaphorin-plexin signaling pathway
intersection_of: part_of GO:0007411 ! axon guidance
relationship: part_of GO:0007411 ! axon guidance
created_by: pr
creation_date: 2013-07-08T16:07:03Z

[Term]
id: GO:1902288
name: regulation of defense response to oomycetes
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of defense response to oomycetes." [GOC:TermGenie, PMID:16040633]
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0032101 ! regulation of response to external stimulus
is_a: GO:0043900 ! regulation of multi-organism process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002229 ! defense response to oomycetes
relationship: regulates GO:0002229 ! defense response to oomycetes
created_by: ms
creation_date: 2013-07-09T13:45:32Z

[Term]
id: GO:1902289
name: negative regulation of defense response to oomycetes
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of defense response to oomycetes." [GOC:TermGenie, PMID:16040633]
synonym: "down regulation of defense response to oomycetes" EXACT [GOC:TermGenie]
synonym: "down-regulation of defense response to oomycetes" EXACT [GOC:TermGenie]
synonym: "downregulation of defense response to oomycetes" EXACT [GOC:TermGenie]
synonym: "inhibition of defense response to oomycetes" NARROW [GOC:TermGenie]
is_a: GO:0002832 ! negative regulation of response to biotic stimulus
is_a: GO:0031348 ! negative regulation of defense response
is_a: GO:0032102 ! negative regulation of response to external stimulus
is_a: GO:0043901 ! negative regulation of multi-organism process
is_a: GO:1902288 ! regulation of defense response to oomycetes
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002229 ! defense response to oomycetes
relationship: negatively_regulates GO:0002229 ! defense response to oomycetes
created_by: ms
creation_date: 2013-07-09T13:45:37Z

[Term]
id: GO:1902290
name: positive regulation of defense response to oomycetes
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of defense response to oomycetes." [GOC:TermGenie, PMID:16040633]
synonym: "activation of defense response to oomycetes" NARROW [GOC:TermGenie]
synonym: "up regulation of defense response to oomycetes" EXACT [GOC:TermGenie]
synonym: "up-regulation of defense response to oomycetes" EXACT [GOC:TermGenie]
synonym: "upregulation of defense response to oomycetes" EXACT [GOC:TermGenie]
is_a: GO:0002833 ! positive regulation of response to biotic stimulus
is_a: GO:0031349 ! positive regulation of defense response
is_a: GO:0032103 ! positive regulation of response to external stimulus
is_a: GO:0043902 ! positive regulation of multi-organism process
is_a: GO:1902288 ! regulation of defense response to oomycetes
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002229 ! defense response to oomycetes
relationship: positively_regulates GO:0002229 ! defense response to oomycetes
created_by: ms
creation_date: 2013-07-09T13:45:43Z

[Term]
id: GO:1902291
name: cell cycle DNA replication DNA ligation
namespace: biological_process
def: "Any DNA ligation that is involved in cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "DNA ligation involved in cell cycle DNA replication" EXACT []
is_a: GO:0022402 ! cell cycle process
is_a: GO:0044710 ! single-organism metabolic process
is_a: GO:0051104 ! DNA-dependent DNA replication DNA ligation
intersection_of: GO:0006266 ! DNA ligation
intersection_of: part_of GO:0044786 ! cell cycle DNA replication
relationship: part_of GO:0044786 ! cell cycle DNA replication
created_by: jl
creation_date: 2013-07-09T16:05:45Z

[Term]
id: GO:1902292
name: cell cycle DNA replication initiation
namespace: biological_process
def: "Any DNA replication initiation that is involved in cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "DNA endoreduplication initiation involved in cell cycle DNA replication" NARROW [GOC:TermGenie]
synonym: "DNA re-replication initiation involved in cell cycle DNA replication" NARROW [GOC:TermGenie]
synonym: "DNA replication initiation involved in cell cycle DNA replication" EXACT []
synonym: "DNA-dependent DNA replication initiation involved in cell cycle DNA replication" EXACT [GOC:TermGenie]
is_a: GO:0006270 ! DNA replication initiation
is_a: GO:0022402 ! cell cycle process
is_a: GO:0044710 ! single-organism metabolic process
intersection_of: GO:0006270 ! DNA replication initiation
intersection_of: part_of GO:0044786 ! cell cycle DNA replication
relationship: part_of GO:0044786 ! cell cycle DNA replication
created_by: jl
creation_date: 2013-07-09T16:05:54Z

[Term]
id: GO:1902294
name: cell cycle DNA replication termination
namespace: biological_process
def: "Any DNA replication termination that is involved in cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "DNA replication termination involved in cell cycle DNA replication" EXACT []
is_a: GO:0006274 ! DNA replication termination
is_a: GO:0022402 ! cell cycle process
is_a: GO:0044710 ! single-organism metabolic process
intersection_of: GO:0006274 ! DNA replication termination
intersection_of: part_of GO:0044786 ! cell cycle DNA replication
relationship: part_of GO:0044786 ! cell cycle DNA replication
created_by: jl
creation_date: 2013-07-09T16:06:11Z

[Term]
id: GO:1902295
name: synthesis of RNA primer involved in cell cycle DNA replication
namespace: biological_process
def: "Any DNA replication, synthesis of RNA primer that is involved in cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "DNA replication, synthesis of RNA primer involved in cell cycle DNA replication" EXACT []
synonym: "replication priming involved in cell cycle DNA replication" RELATED [GOC:TermGenie]
is_a: GO:0006269 ! DNA replication, synthesis of RNA primer
is_a: GO:0022402 ! cell cycle process
is_a: GO:0044711 ! single-organism biosynthetic process
intersection_of: GO:0006269 ! DNA replication, synthesis of RNA primer
intersection_of: part_of GO:0044786 ! cell cycle DNA replication
relationship: part_of GO:0044786 ! cell cycle DNA replication
created_by: jl
creation_date: 2013-07-09T16:06:26Z

[Term]
id: GO:1902296
name: DNA strand elongation involved in cell cycle DNA replication
namespace: biological_process
def: "Any DNA strand elongation that is involved in cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "DNA replication elongation involved in cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "DNA strand elongation during DNA replication involved in cell cycle DNA replication" RELATED [GOC:TermGenie]
is_a: GO:0006271 ! DNA strand elongation involved in DNA replication
is_a: GO:0022402 ! cell cycle process
is_a: GO:0044710 ! single-organism metabolic process
intersection_of: GO:0006271 ! DNA strand elongation involved in DNA replication
intersection_of: part_of GO:0044786 ! cell cycle DNA replication
relationship: part_of GO:0044786 ! cell cycle DNA replication
created_by: jl
creation_date: 2013-07-10T11:47:02Z

[Term]
id: GO:1902297
name: cell cycle DNA replication DNA unwinding
namespace: biological_process
def: "Any DNA unwinding that is involved in cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "DNA unwinding during replication involved in cell cycle DNA replication" RELATED [GOC:TermGenie]
synonym: "DNA unwinding factor involved in cell cycle DNA replication" RELATED [GOC:TermGenie]
synonym: "DNA unwinding involved in cell cycle DNA replication" EXACT []
is_a: GO:0006268 ! DNA unwinding involved in DNA replication
is_a: GO:0022402 ! cell cycle process
is_a: GO:1902589 ! single-organism organelle organization
intersection_of: GO:0006268 ! DNA unwinding involved in DNA replication
intersection_of: part_of GO:0044786 ! cell cycle DNA replication
relationship: part_of GO:0044786 ! cell cycle DNA replication
created_by: jl
creation_date: 2013-07-10T11:47:10Z

[Term]
id: GO:1902298
name: cell cycle DNA replication maintenance of fidelity
namespace: biological_process
def: "Any maintenance of fidelity that is involved in cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "maintenance of fidelity during DNA-dependent DNA replication involved in cell cycle DNA replication" RELATED [GOC:TermGenie]
synonym: "maintenance of fidelity involved in cell cycle DNA replication" EXACT []
is_a: GO:0022402 ! cell cycle process
is_a: GO:0044710 ! single-organism metabolic process
is_a: GO:0045005 ! DNA-dependent DNA replication maintenance of fidelity
intersection_of: GO:0045005 ! DNA-dependent DNA replication maintenance of fidelity
intersection_of: part_of GO:0044786 ! cell cycle DNA replication
relationship: part_of GO:0044786 ! cell cycle DNA replication
created_by: jl
creation_date: 2013-07-10T11:47:19Z

[Term]
id: GO:1902299
name: pre-replicative complex assembly involved in cell cycle DNA replication
namespace: biological_process
def: "Any pre-replicative complex assembly that is involved in cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "pre-RC assembly involved in cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "pre-replication complex assembly involved in cell cycle DNA replication" RELATED [GOC:TermGenie]
is_a: GO:0022402 ! cell cycle process
is_a: GO:0036388 ! pre-replicative complex assembly
intersection_of: GO:0036388 ! pre-replicative complex assembly
intersection_of: part_of GO:0044786 ! cell cycle DNA replication
relationship: part_of GO:0044786 ! cell cycle DNA replication
created_by: jl
creation_date: 2013-07-10T11:47:28Z

[Term]
id: GO:1902300
name: galactarate transport
namespace: biological_process
alt_id: GO:0042871
def: "The directed movement of a galactaric acid anion (galactarate) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:pr, GOC:TermGenie]
synonym: "D-galactarate transport" RELATED []
synonym: "galactaric acid anion transport" EXACT []
is_a: GO:0042869 ! aldarate transport
created_by: pr
creation_date: 2013-07-16T07:11:45Z

[Term]
id: GO:1902301
name: galactarate transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0042877
def: "Enables the transfer of galactaric acid anion (galactarate) from one side of the membrane to the other." [GOC:pr, GOC:TermGenie]
synonym: "D-galactarate transmembrane transporter activity" RELATED []
synonym: "galactaric acid anion transmembrane transporter activity" EXACT []
is_a: GO:0042876 ! aldarate transmembrane transporter activity
relationship: part_of GO:1902300 ! galactarate transport
created_by: pr
creation_date: 2013-07-16T07:26:36Z

[Term]
id: GO:1902302
name: regulation of potassium ion export
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of potassium ion export." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:7604285]
synonym: "regulation of potassium export" EXACT [GOC:TermGenie]
is_a: GO:1901379 ! regulation of potassium ion transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071435 ! potassium ion export
relationship: regulates GO:0071435 ! potassium ion export
created_by: rl
creation_date: 2013-07-17T16:39:53Z

[Term]
id: GO:1902303
name: negative regulation of potassium ion export
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion export." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:7604285]
synonym: "down regulation of potassium export" EXACT [GOC:TermGenie]
synonym: "down regulation of potassium ion export" EXACT [GOC:TermGenie]
synonym: "down-regulation of potassium export" EXACT [GOC:TermGenie]
synonym: "down-regulation of potassium ion export" EXACT [GOC:TermGenie]
synonym: "downregulation of potassium export" EXACT [GOC:TermGenie]
synonym: "downregulation of potassium ion export" EXACT [GOC:TermGenie]
synonym: "inhibition of potassium export" NARROW [GOC:TermGenie]
synonym: "inhibition of potassium ion export" NARROW [GOC:TermGenie]
synonym: "negative regulation of potassium export" EXACT [GOC:TermGenie]
is_a: GO:1901380 ! negative regulation of potassium ion transmembrane transport
is_a: GO:1902302 ! regulation of potassium ion export
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071435 ! potassium ion export
relationship: negatively_regulates GO:0071435 ! potassium ion export
created_by: rl
creation_date: 2013-07-17T16:40:02Z

[Term]
id: GO:1902304
name: positive regulation of potassium ion export
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of potassium ion export." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:7604285]
synonym: "activation of potassium export" NARROW [GOC:TermGenie]
synonym: "activation of potassium ion export" NARROW [GOC:TermGenie]
synonym: "positive regulation of potassium export" EXACT [GOC:TermGenie]
synonym: "up regulation of potassium export" EXACT [GOC:TermGenie]
synonym: "up regulation of potassium ion export" EXACT [GOC:TermGenie]
synonym: "up-regulation of potassium export" EXACT [GOC:TermGenie]
synonym: "up-regulation of potassium ion export" EXACT [GOC:TermGenie]
synonym: "upregulation of potassium export" EXACT [GOC:TermGenie]
synonym: "upregulation of potassium ion export" EXACT [GOC:TermGenie]
is_a: GO:1901381 ! positive regulation of potassium ion transmembrane transport
is_a: GO:1902302 ! regulation of potassium ion export
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071435 ! potassium ion export
relationship: positively_regulates GO:0071435 ! potassium ion export
created_by: rl
creation_date: 2013-07-17T16:40:10Z

[Term]
id: GO:1902305
name: regulation of sodium ion transmembrane transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sodium ion transmembrane transport." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18591664]
synonym: "regulation of sodium ion membrane transport" EXACT [GOC:TermGenie]
is_a: GO:0002028 ! regulation of sodium ion transport
is_a: GO:1904062 ! regulation of cation transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035725 ! sodium ion transmembrane transport
relationship: regulates GO:0035725 ! sodium ion transmembrane transport
created_by: rl
creation_date: 2013-07-18T13:33:53Z

[Term]
id: GO:1902306
name: negative regulation of sodium ion transmembrane transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembrane transport." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18591664]
synonym: "down regulation of sodium ion membrane transport" EXACT [GOC:TermGenie]
synonym: "down regulation of sodium ion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of sodium ion membrane transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of sodium ion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "downregulation of sodium ion membrane transport" EXACT [GOC:TermGenie]
synonym: "downregulation of sodium ion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "inhibition of sodium ion membrane transport" NARROW [GOC:TermGenie]
synonym: "inhibition of sodium ion transmembrane transport" NARROW [GOC:TermGenie]
synonym: "negative regulation of sodium ion membrane transport" EXACT [GOC:TermGenie]
is_a: GO:0010766 ! negative regulation of sodium ion transport
is_a: GO:1902305 ! regulation of sodium ion transmembrane transport
is_a: GO:1904063 ! negative regulation of cation transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035725 ! sodium ion transmembrane transport
relationship: negatively_regulates GO:0035725 ! sodium ion transmembrane transport
created_by: rl
creation_date: 2013-07-18T13:34:01Z

[Term]
id: GO:1902307
name: positive regulation of sodium ion transmembrane transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transport." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18591664]
synonym: "activation of sodium ion membrane transport" NARROW [GOC:TermGenie]
synonym: "activation of sodium ion transmembrane transport" NARROW [GOC:TermGenie]
synonym: "positive regulation of sodium ion membrane transport" EXACT [GOC:TermGenie]
synonym: "up regulation of sodium ion membrane transport" EXACT [GOC:TermGenie]
synonym: "up regulation of sodium ion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of sodium ion membrane transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of sodium ion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "upregulation of sodium ion membrane transport" EXACT [GOC:TermGenie]
synonym: "upregulation of sodium ion transmembrane transport" EXACT [GOC:TermGenie]
is_a: GO:0010765 ! positive regulation of sodium ion transport
is_a: GO:1902305 ! regulation of sodium ion transmembrane transport
is_a: GO:1904064 ! positive regulation of cation transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035725 ! sodium ion transmembrane transport
relationship: positively_regulates GO:0035725 ! sodium ion transmembrane transport
created_by: rl
creation_date: 2013-07-18T13:34:18Z

[Term]
id: GO:1902308
name: regulation of peptidyl-serine dephosphorylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of peptidyl-serine dephosphorylation." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:11953308]
is_a: GO:0035304 ! regulation of protein dephosphorylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070262 ! peptidyl-serine dephosphorylation
relationship: regulates GO:0070262 ! peptidyl-serine dephosphorylation
created_by: rl
creation_date: 2013-07-19T10:34:59Z

[Term]
id: GO:1902309
name: negative regulation of peptidyl-serine dephosphorylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-serine dephosphorylation." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:11953308]
synonym: "down regulation of peptidyl-serine dephosphorylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of peptidyl-serine dephosphorylation" EXACT [GOC:TermGenie]
synonym: "downregulation of peptidyl-serine dephosphorylation" EXACT [GOC:TermGenie]
synonym: "inhibition of peptidyl-serine dephosphorylation" NARROW [GOC:TermGenie]
is_a: GO:0035308 ! negative regulation of protein dephosphorylation
is_a: GO:1902308 ! regulation of peptidyl-serine dephosphorylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070262 ! peptidyl-serine dephosphorylation
relationship: negatively_regulates GO:0070262 ! peptidyl-serine dephosphorylation
created_by: rl
creation_date: 2013-07-19T10:35:07Z

[Term]
id: GO:1902310
name: positive regulation of peptidyl-serine dephosphorylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of peptidyl-serine dephosphorylation." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:11953308]
synonym: "activation of peptidyl-serine dephosphorylation" NARROW [GOC:TermGenie]
synonym: "up regulation of peptidyl-serine dephosphorylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of peptidyl-serine dephosphorylation" EXACT [GOC:TermGenie]
synonym: "upregulation of peptidyl-serine dephosphorylation" EXACT [GOC:TermGenie]
is_a: GO:0035307 ! positive regulation of protein dephosphorylation
is_a: GO:1902308 ! regulation of peptidyl-serine dephosphorylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070262 ! peptidyl-serine dephosphorylation
relationship: positively_regulates GO:0070262 ! peptidyl-serine dephosphorylation
created_by: rl
creation_date: 2013-07-19T10:35:15Z

[Term]
id: GO:1902311
name: regulation of copper ion transmembrane transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of copper ion transmembrane transport." [GOC:di, GOC:TermGenie, PMID:21489137]
synonym: "regulation of copper cation transmembrane transport" EXACT [GOC:TermGenie]
synonym: "regulation of copper ion membrane transport" EXACT [GOC:TermGenie]
is_a: GO:0010959 ! regulation of metal ion transport
is_a: GO:1904062 ! regulation of cation transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035434 ! copper ion transmembrane transport
relationship: regulates GO:0035434 ! copper ion transmembrane transport
created_by: di
creation_date: 2013-07-19T20:59:28Z

[Term]
id: GO:1902312
name: negative regulation of copper ion transmembrane transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of copper ion transmembrane transport." [GOC:di, GOC:TermGenie, PMID:21489137]
synonym: "down regulation of copper cation transmembrane transport" EXACT [GOC:TermGenie]
synonym: "down regulation of copper ion membrane transport" EXACT [GOC:TermGenie]
synonym: "down regulation of copper ion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of copper cation transmembrane transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of copper ion membrane transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of copper ion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "downregulation of copper cation transmembrane transport" EXACT [GOC:TermGenie]
synonym: "downregulation of copper ion membrane transport" EXACT [GOC:TermGenie]
synonym: "downregulation of copper ion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "inhibition of copper cation transmembrane transport" NARROW [GOC:TermGenie]
synonym: "inhibition of copper ion membrane transport" NARROW [GOC:TermGenie]
synonym: "inhibition of copper ion transmembrane transport" NARROW [GOC:TermGenie]
synonym: "negative regulation of copper cation transmembrane transport" EXACT [GOC:TermGenie]
synonym: "negative regulation of copper ion membrane transport" EXACT [GOC:TermGenie]
is_a: GO:1902311 ! regulation of copper ion transmembrane transport
is_a: GO:1904063 ! negative regulation of cation transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035434 ! copper ion transmembrane transport
relationship: negatively_regulates GO:0035434 ! copper ion transmembrane transport
created_by: di
creation_date: 2013-07-19T20:59:37Z

[Term]
id: GO:1902313
name: positive regulation of copper ion transmembrane transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of copper ion transmembrane transport." [GOC:di, GOC:TermGenie, PMID:21489137]
synonym: "activation of copper cation transmembrane transport" NARROW [GOC:TermGenie]
synonym: "activation of copper ion membrane transport" NARROW [GOC:TermGenie]
synonym: "activation of copper ion transmembrane transport" NARROW [GOC:TermGenie]
synonym: "positive regulation of copper cation transmembrane transport" EXACT [GOC:TermGenie]
synonym: "positive regulation of copper ion membrane transport" EXACT [GOC:TermGenie]
synonym: "up regulation of copper cation transmembrane transport" EXACT [GOC:TermGenie]
synonym: "up regulation of copper ion membrane transport" EXACT [GOC:TermGenie]
synonym: "up regulation of copper ion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of copper cation transmembrane transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of copper ion membrane transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of copper ion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "upregulation of copper cation transmembrane transport" EXACT [GOC:TermGenie]
synonym: "upregulation of copper ion membrane transport" EXACT [GOC:TermGenie]
synonym: "upregulation of copper ion transmembrane transport" EXACT [GOC:TermGenie]
is_a: GO:1902311 ! regulation of copper ion transmembrane transport
is_a: GO:1904064 ! positive regulation of cation transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035434 ! copper ion transmembrane transport
relationship: positively_regulates GO:0035434 ! copper ion transmembrane transport
created_by: di
creation_date: 2013-07-19T20:59:45Z

[Term]
id: GO:1902314
name: hydroquinone binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with hydroquinone." [GOC:bhm, GOC:TermGenie, pmid:15667223]
synonym: "quinol binding" EXACT []
is_a: GO:0048037 ! cofactor binding
is_a: GO:0097159 ! organic cyclic compound binding
created_by: bhm
creation_date: 2013-07-22T10:10:12Z

[Term]
id: GO:1902315
name: nuclear cell cycle DNA replication initiation
namespace: biological_process
def: "Any DNA replication initiation that is involved in nuclear cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "DNA endoreduplication initiation involved in nuclear cell cycle DNA replication" NARROW [GOC:TermGenie]
synonym: "DNA re-replication initiation involved in nuclear cell cycle DNA replication" NARROW [GOC:TermGenie]
synonym: "DNA replication initiation involved in nuclear cell cycle DNA replication" EXACT []
is_a: GO:1902292 ! cell cycle DNA replication initiation
intersection_of: GO:0006270 ! DNA replication initiation
intersection_of: part_of GO:0033260 ! nuclear DNA replication
relationship: part_of GO:0033260 ! nuclear DNA replication
created_by: jl
creation_date: 2013-07-23T14:00:01Z

[Term]
id: GO:1902317
name: nuclear DNA replication termination
namespace: biological_process
def: "Any DNA replication termination that is involved in nuclear cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "DNA replication termination involved in DNA replication during S phase" RELATED [GOC:TermGenie]
synonym: "DNA replication termination involved in DNA replication involved in S phase" EXACT [GOC:TermGenie]
synonym: "DNA replication termination involved in DNA replication involved in S-phase" EXACT [GOC:TermGenie]
synonym: "DNA replication termination involved in nuclear cell cycle DNA replication" EXACT []
is_a: GO:1902294 ! cell cycle DNA replication termination
intersection_of: GO:0006274 ! DNA replication termination
intersection_of: part_of GO:0033260 ! nuclear DNA replication
relationship: part_of GO:0033260 ! nuclear DNA replication
created_by: jl
creation_date: 2013-07-23T14:00:17Z

[Term]
id: GO:1902318
name: synthesis of RNA primer involved in nuclear cell cycle DNA replication
namespace: biological_process
def: "Any synthesis of RNA primer that is involved in nuclear cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "DNA replication, synthesis of RNA primer involved in DNA replication during S phase" RELATED [GOC:TermGenie]
synonym: "DNA replication, synthesis of RNA primer involved in DNA replication involved in S phase" EXACT [GOC:TermGenie]
synonym: "DNA replication, synthesis of RNA primer involved in DNA replication involved in S-phase" EXACT [GOC:TermGenie]
synonym: "replication priming involved in DNA replication during S phase" RELATED [GOC:TermGenie]
synonym: "replication priming involved in DNA replication involved in S phase" RELATED [GOC:TermGenie]
synonym: "replication priming involved in DNA replication involved in S-phase" RELATED [GOC:TermGenie]
synonym: "replication priming involved in nuclear cell cycle DNA replication" RELATED [GOC:TermGenie]
is_a: GO:1902295 ! synthesis of RNA primer involved in cell cycle DNA replication
intersection_of: GO:0006269 ! DNA replication, synthesis of RNA primer
intersection_of: part_of GO:0033260 ! nuclear DNA replication
relationship: part_of GO:0033260 ! nuclear DNA replication
created_by: jl
creation_date: 2013-07-23T14:00:33Z

[Term]
id: GO:1902319
name: DNA strand elongation involved in nuclear cell cycle DNA replication
namespace: biological_process
def: "Any DNA strand elongation that is involved in nuclear cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "DNA strand elongation involved in DNA replication during S phase" RELATED [GOC:TermGenie]
synonym: "DNA strand elongation involved in DNA replication involved in S phase" EXACT [GOC:TermGenie]
synonym: "DNA strand elongation involved in DNA replication involved in S-phase" EXACT [GOC:TermGenie]
is_a: GO:1902296 ! DNA strand elongation involved in cell cycle DNA replication
intersection_of: GO:0022616 ! DNA strand elongation
intersection_of: part_of GO:0033260 ! nuclear DNA replication
relationship: part_of GO:0033260 ! nuclear DNA replication
created_by: jl
creation_date: 2013-07-23T14:00:41Z

[Term]
id: GO:1902320
name: nuclear DNA replication DNA duplex unwinding
namespace: biological_process
def: "Any DNA duplex unwinding that is involved in nuclear cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "DNA duplex unwinding involved in DNA replication during S phase" RELATED [GOC:TermGenie]
synonym: "DNA duplex unwinding involved in DNA replication involved in S phase" EXACT [GOC:TermGenie]
synonym: "DNA duplex unwinding involved in DNA replication involved in S-phase" EXACT [GOC:TermGenie]
synonym: "DNA duplex unwinding involved in nuclear cell cycle DNA replication" EXACT []
synonym: "DNA unwinding involved in DNA replication during S phase" RELATED [GOC:TermGenie]
synonym: "DNA unwinding involved in DNA replication involved in S phase" EXACT [GOC:TermGenie]
synonym: "DNA unwinding involved in DNA replication involved in S-phase" EXACT [GOC:TermGenie]
synonym: "DNA unwinding involved in nuclear cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "duplex DNA melting involved in DNA replication during S phase" RELATED [GOC:TermGenie]
synonym: "duplex DNA melting involved in DNA replication involved in S phase" EXACT [GOC:TermGenie]
synonym: "duplex DNA melting involved in DNA replication involved in S-phase" EXACT [GOC:TermGenie]
is_a: GO:1902297 ! cell cycle DNA replication DNA unwinding
intersection_of: GO:0032508 ! DNA duplex unwinding
intersection_of: part_of GO:0033260 ! nuclear DNA replication
relationship: part_of GO:0033260 ! nuclear DNA replication
created_by: jl
creation_date: 2013-07-23T14:00:49Z

[Term]
id: GO:1902321
name: methyl-branched fatty acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of methyl-branched fatty acid." [GOC:kmv, GOC:TermGenie, PMID:15340492]
synonym: "methyl-branched fatty acid anabolism" EXACT [GOC:TermGenie]
synonym: "methyl-branched fatty acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "methyl-branched fatty acid formation" EXACT [GOC:TermGenie]
synonym: "methyl-branched fatty acid synthesis" EXACT [GOC:TermGenie]
is_a: GO:0006633 ! fatty acid biosynthetic process
is_a: GO:0097089 ! methyl-branched fatty acid metabolic process
created_by: kmv
creation_date: 2013-07-23T20:40:46Z

[Term]
id: GO:1902322
name: regulation of methyl-branched fatty acid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of methyl-branched fatty acid biosynthetic process." [GOC:kmv, GOC:TermGenie, PMID:15340492]
synonym: "regulation of methyl-branched fatty acid anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of methyl-branched fatty acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of methyl-branched fatty acid formation" EXACT [GOC:TermGenie]
synonym: "regulation of methyl-branched fatty acid synthesis" EXACT [GOC:TermGenie]
is_a: GO:0042304 ! regulation of fatty acid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1902321 ! methyl-branched fatty acid biosynthetic process
relationship: regulates GO:1902321 ! methyl-branched fatty acid biosynthetic process
created_by: kmv
creation_date: 2013-07-24T20:15:15Z

[Term]
id: GO:1902323
name: negative regulation of methyl-branched fatty acid biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of methyl-branched fatty acid biosynthetic process." [GOC:kmv, GOC:TermGenie, PMID:15340492]
synonym: "down regulation of methyl-branched fatty acid anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of methyl-branched fatty acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of methyl-branched fatty acid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of methyl-branched fatty acid formation" EXACT [GOC:TermGenie]
synonym: "down regulation of methyl-branched fatty acid synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of methyl-branched fatty acid anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of methyl-branched fatty acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of methyl-branched fatty acid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of methyl-branched fatty acid formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of methyl-branched fatty acid synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of methyl-branched fatty acid anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of methyl-branched fatty acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of methyl-branched fatty acid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of methyl-branched fatty acid formation" EXACT [GOC:TermGenie]
synonym: "downregulation of methyl-branched fatty acid synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of methyl-branched fatty acid anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of methyl-branched fatty acid biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of methyl-branched fatty acid biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of methyl-branched fatty acid formation" NARROW [GOC:TermGenie]
synonym: "inhibition of methyl-branched fatty acid synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of methyl-branched fatty acid anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of methyl-branched fatty acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of methyl-branched fatty acid formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of methyl-branched fatty acid synthesis" EXACT [GOC:TermGenie]
is_a: GO:0045717 ! negative regulation of fatty acid biosynthetic process
is_a: GO:1902322 ! regulation of methyl-branched fatty acid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1902321 ! methyl-branched fatty acid biosynthetic process
relationship: negatively_regulates GO:1902321 ! methyl-branched fatty acid biosynthetic process
created_by: kmv
creation_date: 2013-07-24T20:15:23Z

[Term]
id: GO:1902324
name: positive regulation of methyl-branched fatty acid biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of methyl-branched fatty acid biosynthetic process." [GOC:kmv, GOC:TermGenie, PMID:15340492]
synonym: "activation of methyl-branched fatty acid anabolism" NARROW [GOC:TermGenie]
synonym: "activation of methyl-branched fatty acid biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of methyl-branched fatty acid biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of methyl-branched fatty acid formation" NARROW [GOC:TermGenie]
synonym: "activation of methyl-branched fatty acid synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of methyl-branched fatty acid anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of methyl-branched fatty acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of methyl-branched fatty acid formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of methyl-branched fatty acid synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of methyl-branched fatty acid anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of methyl-branched fatty acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of methyl-branched fatty acid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of methyl-branched fatty acid formation" EXACT [GOC:TermGenie]
synonym: "up regulation of methyl-branched fatty acid synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of methyl-branched fatty acid anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of methyl-branched fatty acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of methyl-branched fatty acid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of methyl-branched fatty acid formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of methyl-branched fatty acid synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of methyl-branched fatty acid anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of methyl-branched fatty acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of methyl-branched fatty acid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of methyl-branched fatty acid formation" EXACT [GOC:TermGenie]
synonym: "upregulation of methyl-branched fatty acid synthesis" EXACT [GOC:TermGenie]
is_a: GO:0045723 ! positive regulation of fatty acid biosynthetic process
is_a: GO:1902322 ! regulation of methyl-branched fatty acid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1902321 ! methyl-branched fatty acid biosynthetic process
relationship: positively_regulates GO:1902321 ! methyl-branched fatty acid biosynthetic process
created_by: kmv
creation_date: 2013-07-24T20:15:31Z

[Term]
id: GO:1902325
name: negative regulation of chlorophyll biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chlorophyll biosynthetic process." [GOC:TermGenie, PMID:23555952]
synonym: "down regulation of chlorophyll anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of chlorophyll biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of chlorophyll biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of chlorophyll formation" EXACT [GOC:TermGenie]
synonym: "down regulation of chlorophyll synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of chlorophyll anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of chlorophyll biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of chlorophyll biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of chlorophyll formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of chlorophyll synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of chlorophyll anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of chlorophyll biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of chlorophyll biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of chlorophyll formation" EXACT [GOC:TermGenie]
synonym: "downregulation of chlorophyll synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of chlorophyll anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of chlorophyll biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of chlorophyll biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of chlorophyll formation" NARROW [GOC:TermGenie]
synonym: "inhibition of chlorophyll synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of chlorophyll anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of chlorophyll biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of chlorophyll formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of chlorophyll synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010380 ! regulation of chlorophyll biosynthetic process
is_a: GO:0051195 ! negative regulation of cofactor metabolic process
is_a: GO:1901464 ! negative regulation of tetrapyrrole biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0015995 ! chlorophyll biosynthetic process
relationship: negatively_regulates GO:0015995 ! chlorophyll biosynthetic process
created_by: tb
creation_date: 2013-07-24T22:47:29Z

[Term]
id: GO:1902326
name: positive regulation of chlorophyll biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chlorophyll biosynthetic process." [GOC:TermGenie, PMID:23555952]
synonym: "activation of chlorophyll anabolism" NARROW [GOC:TermGenie]
synonym: "activation of chlorophyll biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of chlorophyll biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of chlorophyll formation" NARROW [GOC:TermGenie]
synonym: "activation of chlorophyll synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of chlorophyll anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of chlorophyll biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of chlorophyll formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of chlorophyll synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of chlorophyll anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of chlorophyll biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of chlorophyll biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of chlorophyll formation" EXACT [GOC:TermGenie]
synonym: "up regulation of chlorophyll synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of chlorophyll anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of chlorophyll biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of chlorophyll biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of chlorophyll formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of chlorophyll synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of chlorophyll anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of chlorophyll biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of chlorophyll biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of chlorophyll formation" EXACT [GOC:TermGenie]
synonym: "upregulation of chlorophyll synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010380 ! regulation of chlorophyll biosynthetic process
is_a: GO:0051194 ! positive regulation of cofactor metabolic process
is_a: GO:1901465 ! positive regulation of tetrapyrrole biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0015995 ! chlorophyll biosynthetic process
relationship: positively_regulates GO:0015995 ! chlorophyll biosynthetic process
created_by: tb
creation_date: 2013-07-24T22:47:37Z

[Term]
id: GO:1902327
name: bacterial-type DNA replication DNA ligation
namespace: biological_process
def: "Any DNA ligation that is involved in bacterial-type DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "DNA ligation involved in bacterial-type DNA replication" EXACT []
is_a: GO:1902291 ! cell cycle DNA replication DNA ligation
intersection_of: GO:0006266 ! DNA ligation
intersection_of: part_of GO:0044787 ! bacterial-type DNA replication
relationship: part_of GO:0044787 ! bacterial-type DNA replication
created_by: jl
creation_date: 2013-07-25T10:47:46Z

[Term]
id: GO:1902328
name: bacterial-type DNA replication initiation
namespace: biological_process
def: "Any DNA replication initiation that is involved in bacterial-type DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "DNA endoreduplication initiation involved in bacterial-type DNA replication" NARROW [GOC:TermGenie]
synonym: "DNA re-replication initiation involved in bacterial-type DNA replication" NARROW [GOC:TermGenie]
synonym: "DNA replication initiation involved in bacterial-type DNA replication" EXACT []
synonym: "DNA-dependent DNA replication initiation involved in bacterial-type DNA replication" EXACT [GOC:TermGenie]
is_a: GO:1902292 ! cell cycle DNA replication initiation
intersection_of: GO:0006270 ! DNA replication initiation
intersection_of: part_of GO:0044787 ! bacterial-type DNA replication
relationship: part_of GO:0044787 ! bacterial-type DNA replication
created_by: jl
creation_date: 2013-07-25T10:48:02Z

[Term]
id: GO:1902329
name: bacterial-type DNA replication termination
namespace: biological_process
def: "Any DNA replication termination that is involved in bacterial-type DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "DNA replication termination involved in bacterial-type DNA replication" EXACT []
is_a: GO:1902294 ! cell cycle DNA replication termination
intersection_of: GO:0006274 ! DNA replication termination
intersection_of: part_of GO:0044787 ! bacterial-type DNA replication
relationship: part_of GO:0044787 ! bacterial-type DNA replication
created_by: jl
creation_date: 2013-07-25T10:48:10Z

[Term]
id: GO:1902330
name: synthesis of RNA primer involved in bacterial-type DNA replication
namespace: biological_process
def: "Any synthesis of RNA primer that is involved in bacterial-type DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "replication priming involved in bacterial-type DNA replication" RELATED [GOC:TermGenie]
is_a: GO:1902295 ! synthesis of RNA primer involved in cell cycle DNA replication
intersection_of: GO:0006269 ! DNA replication, synthesis of RNA primer
intersection_of: part_of GO:0044787 ! bacterial-type DNA replication
relationship: part_of GO:0044787 ! bacterial-type DNA replication
created_by: jl
creation_date: 2013-07-25T10:48:18Z

[Term]
id: GO:1902331
name: DNA strand elongation involved in bacterial-type DNA replication
namespace: biological_process
def: "Any DNA strand elongation that is involved in bacterial-type DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie]
is_a: GO:1902296 ! DNA strand elongation involved in cell cycle DNA replication
intersection_of: GO:0022616 ! DNA strand elongation
intersection_of: part_of GO:0044787 ! bacterial-type DNA replication
relationship: part_of GO:0044787 ! bacterial-type DNA replication
created_by: jl
creation_date: 2013-07-25T10:48:26Z

[Term]
id: GO:1902332
name: bacterial-type DNA replication DNA duplex unwinding
namespace: biological_process
def: "Any DNA duplex unwinding that is involved in bacterial-type DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "DNA duplex unwinding involved in bacterial-type DNA replication" EXACT []
synonym: "DNA unwinding involved in bacterial-type DNA replication" EXACT [GOC:TermGenie]
synonym: "duplex DNA melting involved in bacterial-type DNA replication" EXACT [GOC:TermGenie]
is_a: GO:1902297 ! cell cycle DNA replication DNA unwinding
intersection_of: GO:0032508 ! DNA duplex unwinding
intersection_of: part_of GO:0044787 ! bacterial-type DNA replication
relationship: part_of GO:0044787 ! bacterial-type DNA replication
created_by: jl
creation_date: 2013-07-25T10:48:34Z

[Term]
id: GO:1902333
name: nuclear DNA replication DNA ligation
namespace: biological_process
def: "Any DNA ligation that is involved in nuclear cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "DNA ligation involved in DNA replication during S phase" RELATED [GOC:TermGenie]
synonym: "DNA ligation involved in DNA replication involved in S phase" EXACT [GOC:TermGenie]
synonym: "DNA ligation involved in DNA replication involved in S-phase" EXACT [GOC:TermGenie]
synonym: "DNA ligation involved in nuclear cell cycle DNA replication" EXACT []
is_a: GO:1902291 ! cell cycle DNA replication DNA ligation
intersection_of: GO:0006266 ! DNA ligation
intersection_of: part_of GO:0033260 ! nuclear DNA replication
relationship: part_of GO:0033260 ! nuclear DNA replication
created_by: jl
creation_date: 2013-07-25T10:55:56Z

[Term]
id: GO:1902334
name: fructose export from vacuole to cytoplasm
namespace: biological_process
def: "The directed movement of fructose from vacuole to cytoplasm." [GOC:TermGenie, PMID:23583552]
synonym: "fructose transport from vacuole to cytoplasm" EXACT []
is_a: GO:0015755 ! fructose transport
is_a: GO:0034486 ! vacuolar transmembrane transport
is_a: GO:0035428 ! hexose transmembrane transport
relationship: occurs_in GO:0005622 ! intracellular
created_by: tb
creation_date: 2013-07-26T22:18:12Z

[Term]
id: GO:1902335
name: obsolete positive chemotaxis involved in neuron migration
namespace: biological_process
def: "OBSOLETE. Any positive chemotaxis that is involved in neuron migration." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21658587]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "chemoattraction involved in neuron chemotaxis" EXACT [GOC:TermGenie]
synonym: "chemoattraction involved in neuron guidance" RELATED [GOC:TermGenie]
synonym: "chemoattraction involved in neuron migration" EXACT [GOC:TermGenie]
synonym: "chemoattraction involved in neuronal migration" EXACT [GOC:TermGenie]
synonym: "positive chemotaxis involved in neuron chemotaxis" EXACT [GOC:TermGenie]
synonym: "positive chemotaxis involved in neuron guidance" RELATED [GOC:TermGenie]
synonym: "positive chemotaxis involved in neuron migration" EXACT []
synonym: "positive chemotaxis involved in neuronal migration" EXACT [GOC:TermGenie]
is_obsolete: true
created_by: rl
creation_date: 2013-07-29T12:52:01Z

[Term]
id: GO:1902336
name: positive regulation of retinal ganglion cell axon guidance
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of retinal ganglion cell axon guidance." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21658587]
synonym: "activation of retinal ganglion cell axon guidance" NARROW [GOC:TermGenie]
synonym: "activation of retinal ganglion cell axon pathfinding" NARROW [GOC:TermGenie]
synonym: "positive regulation of retinal ganglion cell axon pathfinding" EXACT [GOC:TermGenie]
synonym: "up regulation of retinal ganglion cell axon guidance" EXACT [GOC:TermGenie]
synonym: "up regulation of retinal ganglion cell axon pathfinding" EXACT [GOC:TermGenie]
synonym: "up-regulation of retinal ganglion cell axon guidance" EXACT [GOC:TermGenie]
synonym: "up-regulation of retinal ganglion cell axon pathfinding" EXACT [GOC:TermGenie]
synonym: "upregulation of retinal ganglion cell axon guidance" EXACT [GOC:TermGenie]
synonym: "upregulation of retinal ganglion cell axon pathfinding" EXACT [GOC:TermGenie]
is_a: GO:0090259 ! regulation of retinal ganglion cell axon guidance
is_a: GO:1902669 ! positive regulation of axon guidance
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0031290 ! retinal ganglion cell axon guidance
relationship: positively_regulates GO:0031290 ! retinal ganglion cell axon guidance
created_by: rl
creation_date: 2013-07-29T13:02:25Z

[Term]
id: GO:1902337
name: regulation of apoptotic process involved in morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of apoptotic process involved in morphogenesis." [GOC:sart, GOC:TermGenie, PMID:12202035]
synonym: "regulation of apoptosis involved in development" RELATED [GOC:TermGenie]
synonym: "regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie]
synonym: "regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0060284 ! regulation of cell development
is_a: GO:1904748 ! regulation of apoptotic process involved in development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060561 ! apoptotic process involved in morphogenesis
relationship: regulates GO:0060561 ! apoptotic process involved in morphogenesis
created_by: sart
creation_date: 2013-07-29T15:03:16Z

[Term]
id: GO:1902338
name: negative regulation of apoptotic process involved in morphogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in morphogenesis." [GOC:sart, GOC:TermGenie, PMID:12202035]
synonym: "down regulation of apoptosis involved in development" RELATED [GOC:TermGenie]
synonym: "down regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie]
synonym: "down regulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie]
synonym: "down-regulation of apoptosis involved in development" RELATED [GOC:TermGenie]
synonym: "down-regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie]
synonym: "downregulation of apoptosis involved in development" RELATED [GOC:TermGenie]
synonym: "downregulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of morphogenetic apoptosis" RELATED [GOC:TermGenie]
synonym: "inhibition of apoptosis involved in development" RELATED [GOC:TermGenie]
synonym: "inhibition of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic process involved in morphogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of morphogenetic apoptosis" RELATED [GOC:TermGenie]
synonym: "negative regulation of apoptosis involved in development" RELATED [GOC:TermGenie]
synonym: "negative regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:1902337 ! regulation of apoptotic process involved in morphogenesis
is_a: GO:1904746 ! negative regulation of apoptotic process involved in development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060561 ! apoptotic process involved in morphogenesis
relationship: negatively_regulates GO:0060561 ! apoptotic process involved in morphogenesis
created_by: sart
creation_date: 2013-07-29T15:03:25Z

[Term]
id: GO:1902339
name: positive regulation of apoptotic process involved in morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in morphogenesis." [GOC:sart, GOC:TermGenie, PMID:12202035]
synonym: "activation of apoptosis involved in development" RELATED [GOC:TermGenie]
synonym: "activation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic process involved in morphogenesis" NARROW [GOC:TermGenie]
synonym: "activation of morphogenetic apoptosis" RELATED [GOC:TermGenie]
synonym: "positive regulation of apoptosis involved in development" RELATED [GOC:TermGenie]
synonym: "positive regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie]
synonym: "up regulation of apoptosis involved in development" RELATED [GOC:TermGenie]
synonym: "up regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie]
synonym: "up-regulation of apoptosis involved in development" RELATED [GOC:TermGenie]
synonym: "up-regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie]
synonym: "upregulation of apoptosis involved in development" RELATED [GOC:TermGenie]
synonym: "upregulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of morphogenetic apoptosis" RELATED [GOC:TermGenie]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:1902337 ! regulation of apoptotic process involved in morphogenesis
is_a: GO:1904747 ! positive regulation of apoptotic process involved in development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060561 ! apoptotic process involved in morphogenesis
relationship: positively_regulates GO:0060561 ! apoptotic process involved in morphogenesis
created_by: sart
creation_date: 2013-07-29T15:03:33Z

[Term]
id: GO:1902340
name: negative regulation of chromosome condensation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chromosome condensation." [GOC:TermGenie, PMID:23219725]
synonym: "down regulation of chromosome condensation" EXACT [GOC:TermGenie]
synonym: "down regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie]
synonym: "down regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie]
synonym: "down-regulation of chromosome condensation" EXACT [GOC:TermGenie]
synonym: "down-regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie]
synonym: "down-regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie]
synonym: "downregulation of chromosome condensation" EXACT [GOC:TermGenie]
synonym: "downregulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie]
synonym: "downregulation of nuclear chromosome condensation" EXACT [GOC:TermGenie]
synonym: "inhibition of chromosome condensation" NARROW [GOC:TermGenie]
synonym: "inhibition of eukaryotic chromosome condensation" NARROW [GOC:TermGenie]
synonym: "inhibition of nuclear chromosome condensation" NARROW [GOC:TermGenie]
synonym: "negative regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie]
synonym: "negative regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie]
is_a: GO:0060623 ! regulation of chromosome condensation
is_a: GO:2001251 ! negative regulation of chromosome organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030261 ! chromosome condensation
relationship: negatively_regulates GO:0030261 ! chromosome condensation
created_by: dgf
creation_date: 2013-07-29T20:54:14Z

[Term]
id: GO:1902341
name: xylitol transport
namespace: biological_process
def: "The directed movement of a xylitol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Xylitol is a polyalcohol (pentane-1,2,3,4,5-pentol), produced by hydrogenation of xylose." [GOC:TermGenie, PMID:23475614]
is_a: GO:0008643 ! carbohydrate transport
is_a: GO:0015791 ! polyol transport
created_by: se
creation_date: 2013-07-30T16:04:38Z

[Term]
id: GO:1902342
name: xylitol export
namespace: biological_process
def: "The directed movement of xylitol out of a cell or organelle." [GOC:TermGenie, PMID:23475614]
is_a: GO:0033231 ! carbohydrate export
is_a: GO:1902341 ! xylitol transport
created_by: se
creation_date: 2013-07-30T16:09:55Z

[Term]
id: GO:1902343
name: regulation of maltose transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of maltose transport." [GOC:dph, GOC:TermGenie, PMID:23770568]
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0015768 ! maltose transport
relationship: regulates GO:0015768 ! maltose transport
created_by: dph
creation_date: 2013-08-01T17:16:18Z

[Term]
id: GO:1902344
name: negative regulation of maltose transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of maltose transport." [GOC:dph, GOC:TermGenie, PMID:23770568]
synonym: "down regulation of maltose transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of maltose transport" EXACT [GOC:TermGenie]
synonym: "downregulation of maltose transport" EXACT [GOC:TermGenie]
synonym: "inhibition of maltose transport" NARROW [GOC:TermGenie]
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:1902343 ! regulation of maltose transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0015768 ! maltose transport
relationship: negatively_regulates GO:0015768 ! maltose transport
created_by: dph
creation_date: 2013-08-01T17:16:26Z

[Term]
id: GO:1902345
name: positive regulation of maltose transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of maltose transport." [GOC:dph, GOC:TermGenie, PMID:23770568]
synonym: "activation of maltose transport" NARROW [GOC:TermGenie]
synonym: "up regulation of maltose transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of maltose transport" EXACT [GOC:TermGenie]
synonym: "upregulation of maltose transport" EXACT [GOC:TermGenie]
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:1902343 ! regulation of maltose transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0015768 ! maltose transport
relationship: positively_regulates GO:0015768 ! maltose transport
created_by: dph
creation_date: 2013-08-01T17:16:34Z

[Term]
id: GO:1902346
name: meiotic strand displacement involved in double-strand break repair via SDSA
namespace: biological_process
def: "Any meiotic strand displacement that is involved in double-strand break repair via synthesis-dependent strand annealing (SDSA)." [GOC:al, GOC:TermGenie, PMID:22723423]
synonym: "meiotic D-loop dissociation involved in double-strand break repair via synthesis-dependent strand annealing" RELATED [GOC:TermGenie]
synonym: "meiotic D-loop dissociation involved in mitotic gene conversion" RELATED [GOC:TermGenie]
synonym: "meiotic D-loop processing involved in double-strand break repair via synthesis-dependent strand annealing" RELATED [GOC:TermGenie]
synonym: "meiotic D-loop processing involved in mitotic gene conversion" RELATED [GOC:TermGenie]
synonym: "meiotic displacement loop dissociation involved in double-strand break repair via synthesis-dependent strand annealing" RELATED [GOC:TermGenie]
synonym: "meiotic displacement loop dissociation involved in mitotic gene conversion" RELATED [GOC:TermGenie]
synonym: "meiotic displacement loop processing involved in double-strand break repair via synthesis-dependent strand annealing" RELATED [GOC:TermGenie]
synonym: "meiotic displacement loop processing involved in mitotic gene conversion" RELATED [GOC:TermGenie]
synonym: "meiotic strand displacement involved in double-strand break repair via synthesis-dependent strand annealing" EXACT []
synonym: "meiotic strand displacement involved in mitotic gene conversion" RELATED [GOC:TermGenie]
synonym: "meiotic strand displacement involved in SDSA" BROAD []
is_a: GO:0000714 ! meiotic strand displacement
intersection_of: GO:0000714 ! meiotic strand displacement
intersection_of: part_of GO:0045003 ! double-strand break repair via synthesis-dependent strand annealing
relationship: part_of GO:0045003 ! double-strand break repair via synthesis-dependent strand annealing
created_by: pr
creation_date: 2013-08-07T12:56:20Z

[Term]
id: GO:1902347
name: response to strigolactone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a strigolactone stimulus." [GOC:TermGenie, PMID:23893171]
synonym: "response to strigolactone analog GR24" RELATED [PMID:23893171]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033993 ! response to lipid
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: dhl
creation_date: 2013-08-08T18:44:57Z

[Term]
id: GO:1902348
name: cellular response to strigolactone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a strigolactone stimulus." [GOC:TermGenie, PMID:23893171]
synonym: "cellular response to strigolactone analog GR24" RELATED [PMID:23893171]
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1902347 ! response to strigolactone
created_by: dhl
creation_date: 2013-08-08T18:45:05Z

[Term]
id: GO:1902349
name: response to chloroquine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chloroquine stimulus." [GOC:kmv, GOC:TermGenie, PMID:23922869]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0043279 ! response to alkaloid
created_by: kmv
creation_date: 2013-08-13T19:29:25Z

[Term]
id: GO:1902350
name: cellular response to chloroquine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chloroquine stimulus." [GOC:kmv, GOC:TermGenie, PMID:23922869]
is_a: GO:0071312 ! cellular response to alkaloid
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1902349 ! response to chloroquine
created_by: kmv
creation_date: 2013-08-13T19:29:33Z

[Term]
id: GO:1902351
name: response to imidacloprid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an imidacloprid stimulus." [GOC:kmv, GOC:TermGenie, PMID:23922869]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
created_by: kmv
creation_date: 2013-08-13T19:33:15Z

[Term]
id: GO:1902352
name: negative regulation of filamentous growth of a population of unicellular organisms in response to starvation by negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A negative regulation of transcription from RNA polymerase II promoter that results in negative regulation of filamentous growth of a population of unicellular organisms in response to starvation." [GOC:rn, GOC:TermGenie, PMID:23223039]
is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
is_a: GO:1900435 ! negative regulation of filamentous growth of a population of unicellular organisms in response to starvation
intersection_of: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
intersection_of: negatively_regulates GO:0036170 ! filamentous growth of a population of unicellular organisms in response to starvation
relationship: negatively_regulates GO:0036170 ! filamentous growth of a population of unicellular organisms in response to starvation
created_by: bf
creation_date: 2013-08-14T09:35:43Z

[Term]
id: GO:1902353
name: positive regulation of induction of conjugation with cellular fusion by negative regulation of transcription from RNA polymerase II promoter by pheromones
namespace: biological_process
def: "A negative regulation of transcription from RNA polymerase II promoter by pheromones that results in positive regulation of induction of conjugation with cellular fusion." [GOC:rn, GOC:TermGenie, PMID:23872066]
synonym: "up regulation of induction of conjugation with cellular fusion by negative regulation of transcription from RNA polymerase II promoter by pheromones" EXACT [GOC:TermGenie]
synonym: "up-regulation of induction of conjugation with cellular fusion by negative regulation of transcription from RNA polymerase II promoter by pheromones" EXACT [GOC:TermGenie]
synonym: "upregulation of induction of conjugation with cellular fusion by negative regulation of transcription from RNA polymerase II promoter by pheromones" EXACT [GOC:TermGenie]
is_a: GO:0046020 ! negative regulation of transcription from RNA polymerase II promoter by pheromones
is_a: GO:1904788 ! positive regulation of induction of conjugation with cellular fusion by regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0046020 ! negative regulation of transcription from RNA polymerase II promoter by pheromones
intersection_of: positively_regulates GO:0010514 ! induction of conjugation with cellular fusion
relationship: positively_regulates GO:0010514 ! induction of conjugation with cellular fusion
created_by: bf
creation_date: 2013-08-14T09:45:21Z

[Term]
id: GO:1902354
name: blood vessel endothelial cell delamination involved in blood vessel lumen ensheathment
namespace: biological_process
def: "Any blood vessel endothelial cell delamination that is involved in blood vessel lumen ensheathment." [GOC:dgh, GOC:TermGenie, PMID:23698350]
is_a: GO:0097497 ! blood vessel endothelial cell delamination
intersection_of: GO:0097497 ! blood vessel endothelial cell delamination
intersection_of: part_of GO:0097496 ! blood vessel lumen ensheathment
relationship: part_of GO:0097496 ! blood vessel lumen ensheathment
created_by: pr
creation_date: 2013-08-14T10:22:00Z

[Term]
id: GO:1902355
name: endothelial tube lumen extension involved in blood vessel lumen ensheathment
namespace: biological_process
def: "Any endothelial tube lumen extension that is involved in blood vessel lumen ensheathment." [GOC:dgh, GOC:TermGenie, PMID:23698350]
is_a: GO:0097498 ! endothelial tube lumen extension
intersection_of: GO:0097498 ! endothelial tube lumen extension
intersection_of: part_of GO:0097496 ! blood vessel lumen ensheathment
relationship: part_of GO:0097496 ! blood vessel lumen ensheathment
created_by: pr
creation_date: 2013-08-14T10:22:09Z

[Term]
id: GO:1902356
name: oxaloacetate(2-) transmembrane transport
namespace: biological_process
def: "The directed movement of oxaloacetate(2-) across a membrane." [GOC:dph, GOC:TermGenie, PMID:18682385]
is_a: GO:0015729 ! oxaloacetate transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport
created_by: dph
creation_date: 2013-08-14T14:40:37Z

[Term]
id: GO:1902357
name: 2-isopropylmalate(2-) transmembrane transport
namespace: biological_process
def: "The directed movement of 2-isopropylmalate(2-) across a membrane." [GOC:dph, GOC:TermGenie, GOC:vw, PMID:18682385]
is_a: GO:0034659 ! isopropylmalate transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport
created_by: dph
creation_date: 2013-08-14T14:43:49Z

[Term]
id: GO:1902358
name: sulfate transmembrane transport
namespace: biological_process
def: "The directed movement of sulfate across a membrane." [GOC:dph, GOC:TermGenie, PMID:9055073]
is_a: GO:0008272 ! sulfate transport
is_a: GO:0098661 ! inorganic anion transmembrane transport
created_by: dph
creation_date: 2013-08-14T14:46:04Z

[Term]
id: GO:1902359
name: Notch signaling pathway involved in somitogenesis
namespace: biological_process
def: "Any Notch signaling pathway that is involved in somitogenesis." [GOC:dph, GOC:TermGenie, PMID:21795391]
synonym: "N signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "N signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "N signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "N signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "Notch receptor signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "Notch receptor signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "Notch receptor signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "Notch receptor signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "Notch signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "Notch signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "Notch signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "Notch-receptor signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "Notch-receptor signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "Notch-receptor signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "Notch-receptor signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
is_a: GO:0007219 ! Notch signaling pathway
intersection_of: GO:0007219 ! Notch signaling pathway
intersection_of: part_of GO:0001756 ! somitogenesis
relationship: part_of GO:0001756 ! somitogenesis
created_by: dph
creation_date: 2013-08-14T17:31:43Z

[Term]
id: GO:1902360
name: conversion of ds siRNA to ss siRNA involved in chromatin silencing by small RNA
namespace: biological_process
def: "Any conversion of ds siRNA to ss siRNA that is involved in chromatin silencing by small RNA." [GOC:TermGenie, GOC:vw, PMID:19239886]
synonym: "conversion of double-stranded small interfering RNA to single-stranded small interfering RNA. involved in chromatin silencing by small RNA" RELATED [GOC:TermGenie]
synonym: "conversion of double-stranded small interfering RNA to single-stranded small interfering RNA. involved in RNA interference-like chromatin silencing" RELATED [GOC:TermGenie]
synonym: "conversion of double-stranded small interfering RNA to single-stranded small interfering RNA. involved in RNA-mediated chromatin silencing" RELATED [GOC:TermGenie]
synonym: "conversion of double-stranded small interfering RNA to single-stranded small interfering RNA. involved in RNA-mediated transcriptional silencing" RELATED [GOC:TermGenie]
synonym: "conversion of double-stranded small interfering RNA to single-stranded small interfering RNA. involved in RNAi-directed chromatin silencing" RELATED [GOC:TermGenie]
synonym: "conversion of double-stranded small interfering RNA to single-stranded small interfering RNA. involved in RNAi-like chromatin silencing" RELATED [GOC:TermGenie]
synonym: "conversion of double-stranded small interfering RNA to single-stranded small interfering RNA. involved in small RNA-mediated heterochromatic silencing" RELATED [GOC:TermGenie]
synonym: "conversion of ds siRNA to ss siRNA involved in RNA interference-like chromatin silencing" EXACT [GOC:TermGenie]
synonym: "conversion of ds siRNA to ss siRNA involved in RNA-mediated chromatin silencing" EXACT [GOC:TermGenie]
synonym: "conversion of ds siRNA to ss siRNA involved in RNA-mediated transcriptional silencing" EXACT [GOC:TermGenie]
synonym: "conversion of ds siRNA to ss siRNA involved in RNAi-directed chromatin silencing" EXACT [GOC:TermGenie]
synonym: "conversion of ds siRNA to ss siRNA involved in RNAi-like chromatin silencing" EXACT [GOC:TermGenie]
synonym: "conversion of ds siRNA to ss siRNA involved in small RNA-mediated heterochromatic silencing" EXACT [GOC:TermGenie]
is_a: GO:0036404 ! conversion of ds siRNA to ss siRNA
intersection_of: GO:0036404 ! conversion of ds siRNA to ss siRNA
intersection_of: part_of GO:0031048 ! chromatin silencing by small RNA
relationship: part_of GO:0031048 ! chromatin silencing by small RNA
created_by: bf
creation_date: 2013-08-15T10:06:18Z

[Term]
id: GO:1902361
name: mitochondrial pyruvate transmembrane transport
namespace: biological_process
def: "The directed movement of pyruvate across a mitochondrial membrane." [GOC:dph, GOC:TermGenie, GOC:vw, PMID:22628558]
synonym: "pyruvate membrane transport in mitochondria" RELATED []
synonym: "pyruvate membrane transport in mitochondrion" RELATED []
synonym: "pyruvate transmembrane transport in mitochondria" RELATED []
synonym: "pyruvate transmembrane transport in mitochondrion" RELATED []
is_a: GO:0006850 ! mitochondrial pyruvate transport
is_a: GO:1901475 ! pyruvate transmembrane transport
is_a: GO:1990542 ! mitochondrial transmembrane transport
created_by: dph
creation_date: 2013-08-15T11:19:35Z

[Term]
id: GO:1902362
name: melanocyte apoptotic process
namespace: biological_process
def: "Any apoptotic process in a melanocyte, the main structural component of the epidermis." [GOC:ic, GOC:TermGenie, PMID:20530876]
synonym: "melanocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "melanophore apoptosis" NARROW [GOC:TermGenie]
synonym: "melanophore apoptotic process" NARROW [GOC:TermGenie]
is_a: GO:0006915 ! apoptotic process
created_by: pr
creation_date: 2013-08-15T16:35:45Z

[Term]
id: GO:1902363
name: regulation of protein localization to spindle pole body
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to spindle pole body." [GOC:TermGenie, PMID:21131906]
synonym: "regulation of protein localisation to spindle pole body" EXACT [GOC:TermGenie]
is_a: GO:1903827 ! regulation of cellular protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071988 ! protein localization to spindle pole body
relationship: regulates GO:0071988 ! protein localization to spindle pole body
created_by: vw
creation_date: 2013-08-15T16:38:07Z

[Term]
id: GO:1902364
name: negative regulation of protein localization to spindle pole body
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to spindle pole body." [GOC:TermGenie, PMID:21131906]
synonym: "down regulation of protein localisation to spindle pole body" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to spindle pole body" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation to spindle pole body" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to spindle pole body" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation to spindle pole body" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to spindle pole body" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localisation to spindle pole body" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to spindle pole body" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation to spindle pole body" EXACT [GOC:TermGenie]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:1902363 ! regulation of protein localization to spindle pole body
is_a: GO:1903828 ! negative regulation of cellular protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071988 ! protein localization to spindle pole body
relationship: negatively_regulates GO:0071988 ! protein localization to spindle pole body
created_by: vw
creation_date: 2013-08-15T16:38:23Z

[Term]
id: GO:1902365
name: positive regulation of protein localization to spindle pole body
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to spindle pole body." [GOC:TermGenie, PMID:21131906]
synonym: "activation of protein localisation to spindle pole body" NARROW [GOC:TermGenie]
synonym: "activation of protein localization to spindle pole body" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein localisation to spindle pole body" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation to spindle pole body" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to spindle pole body" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation to spindle pole body" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to spindle pole body" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation to spindle pole body" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to spindle pole body" EXACT [GOC:TermGenie]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:1902363 ! regulation of protein localization to spindle pole body
is_a: GO:1903829 ! positive regulation of cellular protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071988 ! protein localization to spindle pole body
relationship: positively_regulates GO:0071988 ! protein localization to spindle pole body
created_by: vw
creation_date: 2013-08-15T16:38:31Z

[Term]
id: GO:1902366
name: regulation of Notch signaling pathway involved in somitogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Notch signaling pathway involved in somitogenesis." [GOC:dph, GOC:TermGenie, PMID:21795391]
synonym: "regulation of N signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "regulation of N signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of N signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "regulation of N signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of Notch receptor signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "regulation of Notch receptor signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of Notch receptor signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "regulation of Notch receptor signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of Notch signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "regulation of Notch signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "regulation of Notch signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of Notch-receptor signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "regulation of Notch-receptor signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of Notch-receptor signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "regulation of Notch-receptor signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
is_a: GO:0008593 ! regulation of Notch signaling pathway
is_a: GO:0014807 ! regulation of somitogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1902359 ! Notch signaling pathway involved in somitogenesis
relationship: regulates GO:1902359 ! Notch signaling pathway involved in somitogenesis
created_by: dph
creation_date: 2013-08-20T18:24:23Z

[Term]
id: GO:1902367
name: negative regulation of Notch signaling pathway involved in somitogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of Notch signaling pathway involved in somitogenesis." [GOC:dph, GOC:TermGenie, PMID:21795391]
synonym: "down regulation of N signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "down regulation of N signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of N signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "down regulation of N signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of Notch receptor signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "down regulation of Notch receptor signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of Notch receptor signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "down regulation of Notch receptor signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of Notch signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "down regulation of Notch signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of Notch signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "down regulation of Notch signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of Notch-receptor signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "down regulation of Notch-receptor signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of Notch-receptor signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "down regulation of Notch-receptor signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of N signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "down-regulation of N signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of N signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "down-regulation of N signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of Notch receptor signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "down-regulation of Notch receptor signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of Notch receptor signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "down-regulation of Notch receptor signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of Notch signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "down-regulation of Notch signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of Notch signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "down-regulation of Notch signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of Notch-receptor signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "down-regulation of Notch-receptor signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of Notch-receptor signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "down-regulation of Notch-receptor signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of N signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "downregulation of N signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of N signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "downregulation of N signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of Notch receptor signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "downregulation of Notch receptor signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of Notch receptor signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "downregulation of Notch receptor signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of Notch signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "downregulation of Notch signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of Notch signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "downregulation of Notch signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of Notch-receptor signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "downregulation of Notch-receptor signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of Notch-receptor signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "downregulation of Notch-receptor signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of N signaling pathway involved in formation of mesodermal clusters" NARROW [GOC:TermGenie]
synonym: "inhibition of N signaling pathway involved in somitogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of N signalling pathway involved in formation of mesodermal clusters" NARROW [GOC:TermGenie]
synonym: "inhibition of N signalling pathway involved in somitogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of Notch receptor signaling pathway involved in formation of mesodermal clusters" NARROW [GOC:TermGenie]
synonym: "inhibition of Notch receptor signaling pathway involved in somitogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of Notch receptor signalling pathway involved in formation of mesodermal clusters" NARROW [GOC:TermGenie]
synonym: "inhibition of Notch receptor signalling pathway involved in somitogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of Notch signaling pathway involved in formation of mesodermal clusters" NARROW [GOC:TermGenie]
synonym: "inhibition of Notch signaling pathway involved in somitogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of Notch signalling pathway involved in formation of mesodermal clusters" NARROW [GOC:TermGenie]
synonym: "inhibition of Notch signalling pathway involved in somitogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of Notch-receptor signaling pathway involved in formation of mesodermal clusters" NARROW [GOC:TermGenie]
synonym: "inhibition of Notch-receptor signaling pathway involved in somitogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of Notch-receptor signalling pathway involved in formation of mesodermal clusters" NARROW [GOC:TermGenie]
synonym: "inhibition of Notch-receptor signalling pathway involved in somitogenesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of N signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "negative regulation of N signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of N signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "negative regulation of N signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of Notch receptor signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "negative regulation of Notch receptor signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of Notch receptor signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "negative regulation of Notch receptor signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of Notch signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "negative regulation of Notch signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "negative regulation of Notch signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of Notch-receptor signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "negative regulation of Notch-receptor signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of Notch-receptor signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie]
synonym: "negative regulation of Notch-receptor signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie]
is_a: GO:0045746 ! negative regulation of Notch signaling pathway
is_a: GO:0045992 ! negative regulation of embryonic development
is_a: GO:1902366 ! regulation of Notch signaling pathway involved in somitogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1902359 ! Notch signaling pathway involved in somitogenesis
relationship: negatively_regulates GO:1902359 ! Notch signaling pathway involved in somitogenesis
created_by: dph
creation_date: 2013-08-20T18:27:20Z

[Term]
id: GO:1902368
name: heterochromatin maintenance involved in chromatin silencing at centromere outer repeat region
namespace: biological_process
def: "Any heterochromatin maintenance that is involved in chromatin silencing at centromere outer repeat region." [GOC:TermGenie, GOC:vw, PMID:21289066]
synonym: "heterochromatin maintenance involved in chromatin silencing at centromeric outer repeats" EXACT [GOC:vw]
synonym: "heterochromatin maintenance involved in chromatin silencing at pericentric region" RELATED [GOC:TermGenie]
is_a: GO:0070870 ! heterochromatin maintenance involved in chromatin silencing
intersection_of: GO:0070829 ! heterochromatin maintenance
intersection_of: part_of GO:1990141 ! chromatin silencing at centromere outer repeat region
relationship: part_of GO:1990141 ! chromatin silencing at centromere outer repeat region
created_by: bf
creation_date: 2013-08-21T10:13:39Z

[Term]
id: GO:1902369
name: negative regulation of RNA catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA catabolic process." [GOC:bf, GOC:TermGenie, PMID:16640457]
synonym: "down regulation of RNA breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of RNA catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of RNA catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of RNA degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA degradation" EXACT [GOC:TermGenie]
synonym: "inhibition of RNA breakdown" NARROW [GOC:TermGenie]
synonym: "inhibition of RNA catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of RNA catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of RNA degradation" NARROW [GOC:TermGenie]
synonym: "negative regulation of RNA breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of RNA catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of RNA degradation" EXACT [GOC:TermGenie]
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:0051253 ! negative regulation of RNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006401 ! RNA catabolic process
relationship: negatively_regulates GO:0006401 ! RNA catabolic process
created_by: bf
creation_date: 2013-08-22T14:59:39Z

[Term]
id: GO:1902370
name: regulation of tRNA catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tRNA catabolic process." [GOC:bf, GOC:TermGenie]
synonym: "regulation of tRNA breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of tRNA catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of tRNA degradation" EXACT [GOC:TermGenie]
is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:1903326 ! regulation of tRNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016078 ! tRNA catabolic process
relationship: regulates GO:0016078 ! tRNA catabolic process
created_by: bf
creation_date: 2013-08-22T15:08:12Z

[Term]
id: GO:1902371
name: negative regulation of tRNA catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tRNA catabolic process." [GOC:bf, GOC:TermGenie, PMID:22919049]
synonym: "down regulation of tRNA breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of tRNA catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of tRNA catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of tRNA degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of tRNA breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of tRNA catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of tRNA catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of tRNA degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of tRNA breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of tRNA catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of tRNA catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of tRNA degradation" EXACT [GOC:TermGenie]
synonym: "inhibition of tRNA breakdown" NARROW [GOC:TermGenie]
synonym: "inhibition of tRNA catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of tRNA catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of tRNA degradation" NARROW [GOC:TermGenie]
synonym: "negative regulation of tRNA breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of tRNA catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of tRNA degradation" EXACT [GOC:TermGenie]
is_a: GO:1902369 ! negative regulation of RNA catabolic process
is_a: GO:1902370 ! regulation of tRNA catabolic process
is_a: GO:1903327 ! negative regulation of tRNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016078 ! tRNA catabolic process
relationship: negatively_regulates GO:0016078 ! tRNA catabolic process
created_by: bf
creation_date: 2013-08-22T15:08:20Z

[Term]
id: GO:1902372
name: positive regulation of tRNA catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tRNA catabolic process." [GOC:bf, GOC:TermGenie]
synonym: "activation of tRNA breakdown" NARROW [GOC:TermGenie]
synonym: "activation of tRNA catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of tRNA catabolism" NARROW [GOC:TermGenie]
synonym: "activation of tRNA degradation" NARROW [GOC:TermGenie]
synonym: "positive regulation of tRNA breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of tRNA catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of tRNA degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of tRNA breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of tRNA catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of tRNA catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of tRNA degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of tRNA breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of tRNA catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of tRNA catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of tRNA degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of tRNA breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of tRNA catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of tRNA catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of tRNA degradation" EXACT [GOC:TermGenie]
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:1902370 ! regulation of tRNA catabolic process
is_a: GO:1903328 ! positive regulation of tRNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016078 ! tRNA catabolic process
relationship: positively_regulates GO:0016078 ! tRNA catabolic process
created_by: bf
creation_date: 2013-08-22T15:08:29Z

[Term]
id: GO:1902373
name: negative regulation of mRNA catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA catabolic process." [GOC:bf, GOC:TermGenie, PMID:22626865]
synonym: "down regulation of mRNA breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of mRNA catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of mRNA catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of mRNA decay" RELATED [GOC:TermGenie]
synonym: "down regulation of mRNA degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of mRNA breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of mRNA catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of mRNA catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of mRNA decay" RELATED [GOC:TermGenie]
synonym: "down-regulation of mRNA degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of mRNA breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of mRNA catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of mRNA catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of mRNA decay" RELATED [GOC:TermGenie]
synonym: "downregulation of mRNA degradation" EXACT [GOC:TermGenie]
synonym: "inhibition of mRNA breakdown" NARROW [GOC:TermGenie]
synonym: "inhibition of mRNA catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of mRNA catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of mRNA decay" RELATED [GOC:TermGenie]
synonym: "inhibition of mRNA degradation" NARROW [GOC:TermGenie]
synonym: "negative regulation of mRNA breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of mRNA catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of mRNA decay" RELATED [GOC:TermGenie]
synonym: "negative regulation of mRNA degradation" EXACT [GOC:TermGenie]
is_a: GO:0061013 ! regulation of mRNA catabolic process
is_a: GO:1902369 ! negative regulation of RNA catabolic process
is_a: GO:1903312 ! negative regulation of mRNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006402 ! mRNA catabolic process
relationship: negatively_regulates GO:0006402 ! mRNA catabolic process
created_by: bf
creation_date: 2013-08-22T15:16:19Z

[Term]
id: GO:1902374
name: regulation of rRNA catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of rRNA catabolic process." [GOC:bf, GOC:TermGenie, PMID:20160119]
synonym: "regulation of rRNA breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of rRNA catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of rRNA degradation" EXACT [GOC:TermGenie]
is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:0051252 ! regulation of RNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016075 ! rRNA catabolic process
relationship: regulates GO:0016075 ! rRNA catabolic process
created_by: bf
creation_date: 2013-08-22T15:20:59Z

[Term]
id: GO:1902375
name: nuclear tRNA 3'-trailer cleavage, endonucleolytic
namespace: biological_process
def: "Any tRNA 3'-trailer cleavage, endonucleolytic that takes place in nucleus." [GOC:TermGenie, PMID:23928301]
synonym: "endonucleolytic tRNA 3'-end cleavage in cell nucleus" EXACT [GOC:TermGenie]
synonym: "endonucleolytic tRNA 3'-end cleavage in nucleus" EXACT [GOC:TermGenie]
synonym: "endonucleolytic tRNA 3'-trailer cleavage in cell nucleus" RELATED [GOC:TermGenie]
synonym: "endonucleolytic tRNA 3'-trailer cleavage in nucleus" RELATED [GOC:TermGenie]
synonym: "tRNA 3'-end cleavage, endonucleolytic in cell nucleus" EXACT [GOC:TermGenie]
synonym: "tRNA 3'-end cleavage, endonucleolytic in nucleus" EXACT [GOC:TermGenie]
synonym: "tRNA 3'-trailer cleavage, endonucleolytic in cell nucleus" EXACT [GOC:TermGenie]
is_a: GO:0034414 ! tRNA 3'-trailer cleavage, endonucleolytic
intersection_of: GO:0034414 ! tRNA 3'-trailer cleavage, endonucleolytic
intersection_of: occurs_in GO:0005634 ! nucleus
relationship: occurs_in GO:0005634 ! nucleus
created_by: al
creation_date: 2013-08-30T09:17:30Z

[Term]
id: GO:1902376
name: protein denaturation involved in proteasomal ubiquitin-dependent protein catabolic process
namespace: biological_process
def: "Any protein denaturation that is involved in proteasomal ubiquitin-dependent protein catabolic process." [GOC:TermGenie, PMID:21091378]
synonym: "protein denaturation involved in proteasomal pathway" EXACT [GOC:TermGenie]
synonym: "protein denaturation involved in proteasomal processing" RELATED [GOC:TermGenie]
synonym: "protein denaturation involved in proteasomal ubiquitin-dependent protein breakdown" EXACT [GOC:TermGenie]
synonym: "protein denaturation involved in proteasomal ubiquitin-dependent protein catabolism" EXACT [GOC:TermGenie]
synonym: "protein denaturation involved in proteasomal ubiquitin-dependent protein degradation" EXACT [GOC:TermGenie]
synonym: "protein denaturation involved in proteasome pathway" RELATED [GOC:TermGenie]
is_a: GO:0030164 ! protein denaturation
intersection_of: GO:0030164 ! protein denaturation
intersection_of: part_of GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process
relationship: part_of GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process
created_by: al
creation_date: 2013-08-30T09:29:14Z

[Term]
id: GO:1902377
name: nuclear rDNA heterochromatin
namespace: cellular_component
def: "Any rDNA heterochromatin that is part of a nucleus." [GOC:TermGenie, PMID:20661445]
synonym: "rDNA heterochromatin of cell nucleus" EXACT [GOC:TermGenie]
synonym: "rDNA heterochromatin of nucleus" EXACT [GOC:TermGenie]
synonym: "ribosomal DNA heterochromatin of cell nucleus" EXACT [GOC:TermGenie]
synonym: "ribosomal DNA heterochromatin of nucleus" EXACT [GOC:TermGenie]
is_a: GO:0005720 ! nuclear heterochromatin
is_a: GO:0033553 ! rDNA heterochromatin
intersection_of: GO:0033553 ! rDNA heterochromatin
intersection_of: part_of GO:0005634 ! nucleus
relationship: part_of GO:0005634 ! nucleus
created_by: al
creation_date: 2013-08-30T09:59:42Z

[Term]
id: GO:1902378
name: VEGF-activated neuropilin signaling pathway involved in axon guidance
namespace: biological_process
def: "Any VEGF-activated neuropilin signaling pathway that is involved in axon guidance." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21658587]
synonym: "vascular endothelial growth factor-activated neuropilin signaling pathway involved in axon chemotaxis" RELATED [GOC:TermGenie]
synonym: "vascular endothelial growth factor-activated neuropilin signaling pathway involved in axon growth cone guidance" RELATED [GOC:TermGenie]
synonym: "vascular endothelial growth factor-activated neuropilin signaling pathway involved in axon guidance" RELATED [GOC:TermGenie]
synonym: "vascular endothelial growth factor-activated neuropilin signaling pathway involved in axon pathfinding" RELATED [GOC:TermGenie]
synonym: "VEGF-activated neuropilin signaling pathway involved in axon chemotaxis" RELATED [GOC:TermGenie]
synonym: "VEGF-activated neuropilin signaling pathway involved in axon growth cone guidance" NARROW [GOC:TermGenie]
synonym: "VEGF-activated neuropilin signaling pathway involved in axon pathfinding" EXACT [GOC:TermGenie]
synonym: "VEGF-Npn-1 signaling involved in axon chemotaxis" RELATED [GOC:TermGenie]
synonym: "VEGF-Npn-1 signaling involved in axon growth cone guidance" NARROW [GOC:TermGenie]
synonym: "VEGF-Npn-1 signaling involved in axon guidance" NARROW [GOC:TermGenie]
synonym: "VEGF-Npn-1 signaling involved in axon pathfinding" NARROW [GOC:TermGenie]
is_a: GO:0038190 ! VEGF-activated neuropilin signaling pathway
intersection_of: GO:0038190 ! VEGF-activated neuropilin signaling pathway
intersection_of: part_of GO:0007411 ! axon guidance
relationship: part_of GO:0007411 ! axon guidance
created_by: bf
creation_date: 2013-09-02T13:44:13Z

[Term]
id: GO:1902379
name: chemoattractant activity involved in axon guidance
namespace: molecular_function
def: "Any chemoattractant activity that is involved in axon guidance." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21658587]
synonym: "chemoattractant activity involved in axon chemotaxis" RELATED [GOC:TermGenie]
synonym: "chemoattractant activity involved in axon growth cone guidance" NARROW [GOC:TermGenie]
synonym: "chemoattractant activity involved in axon pathfinding" EXACT [GOC:TermGenie]
is_a: GO:0042056 ! chemoattractant activity
intersection_of: GO:0042056 ! chemoattractant activity
intersection_of: part_of GO:0007411 ! axon guidance
relationship: part_of GO:0007411 ! axon guidance
relationship: part_of GO:0061642 ! chemoattraction of axon
created_by: bf
creation_date: 2013-09-02T13:49:35Z

[Term]
id: GO:1902380
name: positive regulation of endoribonuclease activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endoribonuclease activity." [GOC:bf, GOC:TermGenie]
synonym: "activation of endonuclease G activity" RELATED [GOC:TermGenie]
synonym: "activation of endoribonuclease activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of endonuclease G activity" RELATED [GOC:TermGenie]
synonym: "up regulation of endonuclease G activity" RELATED [GOC:TermGenie]
synonym: "up regulation of endoribonuclease activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of endonuclease G activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of endoribonuclease activity" EXACT [GOC:TermGenie]
synonym: "upregulation of endonuclease G activity" RELATED [GOC:TermGenie]
synonym: "upregulation of endoribonuclease activity" EXACT [GOC:TermGenie]
is_a: GO:0032075 ! positive regulation of nuclease activity
is_a: GO:0051254 ! positive regulation of RNA metabolic process
is_a: GO:0060699 ! regulation of endoribonuclease activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004521 ! endoribonuclease activity
relationship: positively_regulates GO:0004521 ! endoribonuclease activity
created_by: bf
creation_date: 2013-09-02T14:14:29Z

[Term]
id: GO:1902381
name: 11-oxo-beta-amyrin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 11-oxo-beta-amyrin." [GOC:TermGenie, pmid:22128119]
synonym: "11-oxo-beta-amyrin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019742 ! pentacyclic triterpenoid metabolic process
is_a: GO:0042180 ! cellular ketone metabolic process
created_by: ms
creation_date: 2013-09-03T12:55:29Z

[Term]
id: GO:1902382
name: 11-oxo-beta-amyrin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 11-oxo-beta-amyrin." [GOC:TermGenie, pmid:22128119]
synonym: "11-oxo-beta-amyrin breakdown" EXACT [GOC:TermGenie]
synonym: "11-oxo-beta-amyrin catabolism" EXACT [GOC:TermGenie]
synonym: "11-oxo-beta-amyrin degradation" EXACT [GOC:TermGenie]
is_a: GO:0019741 ! pentacyclic triterpenoid catabolic process
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:1902381 ! 11-oxo-beta-amyrin metabolic process
created_by: ms
creation_date: 2013-09-03T12:55:38Z

[Term]
id: GO:1902383
name: 11-oxo-beta-amyrin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 11-oxo-beta-amyrin." [GOC:TermGenie, pmid:22128119]
synonym: "11-oxo-beta-amyrin anabolism" EXACT [GOC:TermGenie]
synonym: "11-oxo-beta-amyrin biosynthesis" EXACT [GOC:TermGenie]
synonym: "11-oxo-beta-amyrin formation" EXACT [GOC:TermGenie]
synonym: "11-oxo-beta-amyrin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0019745 ! pentacyclic triterpenoid biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:1902381 ! 11-oxo-beta-amyrin metabolic process
created_by: ms
creation_date: 2013-09-03T12:55:46Z

[Term]
id: GO:1902384
name: glycyrrhetinate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycyrrhetinate." [GOC:TermGenie, pmid:22128119]
synonym: "glycyrrhetinate metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019742 ! pentacyclic triterpenoid metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042180 ! cellular ketone metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process
created_by: ms
creation_date: 2013-09-03T12:55:55Z

[Term]
id: GO:1902385
name: glycyrrhetinate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycyrrhetinate." [GOC:TermGenie, pmid:22128119]
synonym: "glycyrrhetinate breakdown" EXACT [GOC:TermGenie]
synonym: "glycyrrhetinate catabolism" EXACT [GOC:TermGenie]
synonym: "glycyrrhetinate degradation" EXACT [GOC:TermGenie]
is_a: GO:0019741 ! pentacyclic triterpenoid catabolic process
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:1901616 ! organic hydroxy compound catabolic process
is_a: GO:1902384 ! glycyrrhetinate metabolic process
created_by: ms
creation_date: 2013-09-03T12:56:10Z

[Term]
id: GO:1902386
name: glycyrrhetinate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycyrrhetinate." [GOC:TermGenie, pmid:22128119]
synonym: "glycyrrhetinate anabolism" EXACT [GOC:TermGenie]
synonym: "glycyrrhetinate biosynthesis" EXACT [GOC:TermGenie]
synonym: "glycyrrhetinate formation" EXACT [GOC:TermGenie]
synonym: "glycyrrhetinate synthesis" EXACT [GOC:TermGenie]
is_a: GO:0019745 ! pentacyclic triterpenoid biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process
is_a: GO:1902384 ! glycyrrhetinate metabolic process
created_by: ms
creation_date: 2013-09-03T12:56:19Z

[Term]
id: GO:1902387
name: ceramide 1-phosphate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with ceramide 1-phosphate." [GOC:TermGenie, PMID:23863933]
is_a: GO:0005543 ! phospholipid binding
is_a: GO:0097001 ! ceramide binding
created_by: uh
creation_date: 2013-09-05T05:51:08Z

[Term]
id: GO:1902388
name: ceramide 1-phosphate transporter activity
namespace: molecular_function
def: "Enables the directed movement of ceramide 1-phosphate into, out of or within a cell, or between cells." [GOC:TermGenie, PMID:23863933]
is_a: GO:0005548 ! phospholipid transporter activity
is_a: GO:0035620 ! ceramide transporter activity
relationship: part_of GO:1902389 ! ceramide 1-phosphate transport
created_by: uh
creation_date: 2013-09-05T05:57:55Z

[Term]
id: GO:1902389
name: ceramide 1-phosphate transport
namespace: biological_process
def: "The directed movement of a ceramide 1-phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:TermGenie, PMID:23863933]
is_a: GO:0015914 ! phospholipid transport
is_a: GO:0035627 ! ceramide transport
created_by: uh
creation_date: 2013-09-05T06:02:35Z

[Term]
id: GO:1902390
name: regulation of N-terminal peptidyl-serine acetylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of N-terminal peptidyl-serine acetylation." [GOC:TermGenie, PMID:23912279]
is_a: GO:1901983 ! regulation of protein acetylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0017198 ! N-terminal peptidyl-serine acetylation
relationship: regulates GO:0017198 ! N-terminal peptidyl-serine acetylation
created_by: al
creation_date: 2013-09-11T14:46:45Z

[Term]
id: GO:1902391
name: positive regulation of N-terminal peptidyl-serine acetylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of N-terminal peptidyl-serine acetylation." [GOC:TermGenie, PMID:23912279]
synonym: "activation of N-terminal peptidyl-serine acetylation" NARROW [GOC:TermGenie]
synonym: "up regulation of N-terminal peptidyl-serine acetylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of N-terminal peptidyl-serine acetylation" EXACT [GOC:TermGenie]
synonym: "upregulation of N-terminal peptidyl-serine acetylation" EXACT [GOC:TermGenie]
is_a: GO:1901985 ! positive regulation of protein acetylation
is_a: GO:1902390 ! regulation of N-terminal peptidyl-serine acetylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0017198 ! N-terminal peptidyl-serine acetylation
relationship: positively_regulates GO:0017198 ! N-terminal peptidyl-serine acetylation
created_by: al
creation_date: 2013-09-11T14:46:54Z

[Term]
id: GO:1902392
name: regulation of exodeoxyribonuclease activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of exodeoxyribonuclease activity." [GOC:jl, GOC:TermGenie]
is_a: GO:0032070 ! regulation of deoxyribonuclease activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004529 ! exodeoxyribonuclease activity
relationship: regulates GO:0004529 ! exodeoxyribonuclease activity
created_by: jl
creation_date: 2013-09-11T14:56:14Z

[Term]
id: GO:1902393
name: negative regulation of exodeoxyribonuclease activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of exodeoxyribonuclease activity." [GOC:jl, GOC:TermGenie]
synonym: "down regulation of exodeoxyribonuclease activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of exodeoxyribonuclease activity" EXACT [GOC:TermGenie]
synonym: "downregulation of exodeoxyribonuclease activity" EXACT [GOC:TermGenie]
synonym: "inhibition of exodeoxyribonuclease activity" NARROW [GOC:TermGenie]
is_a: GO:0032076 ! negative regulation of deoxyribonuclease activity
is_a: GO:1902392 ! regulation of exodeoxyribonuclease activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004529 ! exodeoxyribonuclease activity
relationship: negatively_regulates GO:0004529 ! exodeoxyribonuclease activity
created_by: jl
creation_date: 2013-09-11T14:56:23Z

[Term]
id: GO:1902394
name: positive regulation of exodeoxyribonuclease activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of exodeoxyribonuclease activity." [GOC:jl, GOC:TermGenie, PMID:1234]
synonym: "activation of exodeoxyribonuclease activity" NARROW [GOC:TermGenie]
synonym: "up regulation of exodeoxyribonuclease activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of exodeoxyribonuclease activity" EXACT [GOC:TermGenie]
synonym: "upregulation of exodeoxyribonuclease activity" EXACT [GOC:TermGenie]
is_a: GO:0032077 ! positive regulation of deoxyribonuclease activity
is_a: GO:1902392 ! regulation of exodeoxyribonuclease activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004529 ! exodeoxyribonuclease activity
relationship: positively_regulates GO:0004529 ! exodeoxyribonuclease activity
created_by: jl
creation_date: 2013-09-11T14:56:38Z

[Term]
id: GO:1902395
name: regulation of 1-deoxy-D-xylulose-5-phosphate synthase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of 1-deoxy-D-xylulose-5-phosphate synthase activity." [GOC:TermGenie, PMID:23612965]
synonym: "regulation of 1-deoxy-D-xylulose-5-phosphate pyruvate-lyase (carboxylating) activity" EXACT [GOC:TermGenie]
synonym: "regulation of 1-deoxyxylulose-5-phosphate synthase activity" EXACT [GOC:TermGenie]
synonym: "regulation of DOXP synthase activity" EXACT [GOC:TermGenie]
synonym: "regulation of DXP-synthase activity" EXACT [GOC:TermGenie]
synonym: "regulation of pyruvate:D-glyceraldehyde-3-phosphate acetaldehydetransferase (decarboxylating)" EXACT [GOC:TermGenie]
is_a: GO:0051338 ! regulation of transferase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008661 ! 1-deoxy-D-xylulose-5-phosphate synthase activity
relationship: regulates GO:0008661 ! 1-deoxy-D-xylulose-5-phosphate synthase activity
created_by: tb
creation_date: 2013-09-11T21:12:25Z

[Term]
id: GO:1902396
name: protein localization to bicellular tight junction
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a tight junction." [GOC:TermGenie, PMID:18332111]
synonym: "protein localisation in tight junction" EXACT [GOC:TermGenie]
synonym: "protein localisation to tight junction" EXACT [GOC:TermGenie]
synonym: "protein localization in tight junction" EXACT [GOC:TermGenie]
is_a: GO:1902414 ! protein localization to cell junction
created_by: tb
creation_date: 2013-09-11T21:43:13Z

[Term]
id: GO:1902397
name: detection of stimulus involved in meiotic spindle checkpoint
namespace: biological_process
def: "Any detection of stimulus that is involved in meiotic spindle checkpoint." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "perception of stimulus involved in meiotic spindle checkpoint" RELATED [GOC:TermGenie]
synonym: "stimulus detection involved in meiotic spindle checkpoint" EXACT [GOC:TermGenie]
synonym: "stimulus sensing involved in meiotic spindle checkpoint" RELATED [GOC:TermGenie]
is_a: GO:0022414 ! reproductive process
is_a: GO:0051606 ! detection of stimulus
intersection_of: GO:0051606 ! detection of stimulus
intersection_of: part_of GO:0044779 ! meiotic spindle checkpoint
relationship: part_of GO:0044779 ! meiotic spindle checkpoint
created_by: jl
creation_date: 2013-09-12T12:01:32Z

[Term]
id: GO:1902398
name: intracellular signal transduction involved in meiotic spindle checkpoint
namespace: biological_process
def: "Any intracellular signal transduction that is involved in meiotic spindle checkpoint." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "intracellular signal transduction pathway involved in meiotic spindle checkpoint" NARROW [GOC:TermGenie]
synonym: "intracellular signaling cascade involved in meiotic spindle checkpoint" EXACT [GOC:TermGenie]
synonym: "intracellular signaling chain involved in meiotic spindle checkpoint" EXACT [GOC:TermGenie]
synonym: "intracellular signaling pathway involved in meiotic spindle checkpoint" RELATED [GOC:TermGenie]
synonym: "signal transduction via intracellular signaling cascade involved in meiotic spindle checkpoint" RELATED [GOC:TermGenie]
synonym: "signal transmission via intracellular cascade involved in meiotic spindle checkpoint" NARROW [GOC:TermGenie]
is_a: GO:0072411 ! signal transduction involved in meiotic cell cycle checkpoint
is_a: GO:0072416 ! signal transduction involved in spindle checkpoint
intersection_of: GO:0035556 ! intracellular signal transduction
intersection_of: part_of GO:0044779 ! meiotic spindle checkpoint
relationship: part_of GO:0044779 ! meiotic spindle checkpoint
created_by: jl
creation_date: 2013-09-12T12:01:41Z

[Term]
id: GO:1902399
name: detection of stimulus involved in G1 DNA damage checkpoint
namespace: biological_process
def: "Any detection of stimulus that is involved in G1 DNA damage checkpoint." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "detection of stimulus involved in G1/S DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "perception of stimulus involved in G1 DNA damage checkpoint" RELATED [GOC:TermGenie]
synonym: "perception of stimulus involved in G1/S DNA damage checkpoint" RELATED [GOC:TermGenie]
synonym: "stimulus detection involved in G1 DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "stimulus detection involved in G1/S DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "stimulus sensing involved in G1 DNA damage checkpoint" RELATED [GOC:TermGenie]
synonym: "stimulus sensing involved in G1/S DNA damage checkpoint" RELATED [GOC:TermGenie]
is_a: GO:0051606 ! detection of stimulus
intersection_of: GO:0051606 ! detection of stimulus
intersection_of: part_of GO:0044783 ! G1 DNA damage checkpoint
relationship: part_of GO:0044783 ! G1 DNA damage checkpoint
created_by: jl
creation_date: 2013-09-12T12:01:49Z

[Term]
id: GO:1902400
name: intracellular signal transduction involved in G1 DNA damage checkpoint
namespace: biological_process
def: "Any intracellular signal transduction that is involved in G1 DNA damage checkpoint." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "intracellular signal transduction involved in G1/S DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "intracellular signal transduction pathway involved in G1 DNA damage checkpoint" NARROW [GOC:TermGenie]
synonym: "intracellular signal transduction pathway involved in G1/S DNA damage checkpoint" NARROW [GOC:TermGenie]
synonym: "intracellular signaling cascade involved in G1 DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "intracellular signaling cascade involved in G1/S DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "intracellular signaling chain involved in G1 DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "intracellular signaling chain involved in G1/S DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "intracellular signaling pathway involved in G1 DNA damage checkpoint" RELATED [GOC:TermGenie]
synonym: "intracellular signaling pathway involved in G1/S DNA damage checkpoint" RELATED [GOC:TermGenie]
synonym: "signal transduction via intracellular signaling cascade involved in G1 DNA damage checkpoint" RELATED [GOC:TermGenie]
synonym: "signal transduction via intracellular signaling cascade involved in G1/S DNA damage checkpoint" RELATED [GOC:TermGenie]
synonym: "signal transmission via intracellular cascade involved in G1 DNA damage checkpoint" NARROW [GOC:TermGenie]
synonym: "signal transmission via intracellular cascade involved in G1/S DNA damage checkpoint" NARROW [GOC:TermGenie]
is_a: GO:0072422 ! signal transduction involved in DNA damage checkpoint
is_a: GO:1902807 ! negative regulation of cell cycle G1/S phase transition
intersection_of: GO:0035556 ! intracellular signal transduction
intersection_of: part_of GO:0044783 ! G1 DNA damage checkpoint
relationship: part_of GO:0044783 ! G1 DNA damage checkpoint
created_by: jl
creation_date: 2013-09-12T12:01:58Z

[Term]
id: GO:1902401
name: detection of stimulus involved in mitotic DNA damage checkpoint
namespace: biological_process
def: "Any detection of stimulus that is involved in mitotic DNA damage checkpoint." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "perception of stimulus involved in mitotic DNA damage checkpoint" RELATED [GOC:TermGenie]
synonym: "stimulus detection involved in mitotic DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "stimulus sensing involved in mitotic DNA damage checkpoint" RELATED [GOC:TermGenie]
is_a: GO:0072400 ! detection of stimulus involved in mitotic DNA integrity checkpoint
intersection_of: GO:0051606 ! detection of stimulus
intersection_of: part_of GO:0044773 ! mitotic DNA damage checkpoint
relationship: part_of GO:0044773 ! mitotic DNA damage checkpoint
created_by: jl
creation_date: 2013-09-12T12:07:12Z

[Term]
id: GO:1902402
name: signal transduction involved in mitotic DNA damage checkpoint
namespace: biological_process
def: "Any intracellular signal transduction that is involved in mitotic DNA damage checkpoint." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "intracellular signal transduction pathway involved in mitotic DNA damage checkpoint" NARROW [GOC:TermGenie]
synonym: "intracellular signaling cascade involved in mitotic DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "intracellular signaling chain involved in mitotic DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "intracellular signaling pathway involved in mitotic DNA damage checkpoint" RELATED [GOC:TermGenie]
synonym: "signal transduction via intracellular signaling cascade involved in mitotic DNA damage checkpoint" RELATED [GOC:TermGenie]
synonym: "signal transmission via intracellular cascade involved in mitotic DNA damage checkpoint" NARROW [GOC:TermGenie]
is_a: GO:0072422 ! signal transduction involved in DNA damage checkpoint
is_a: GO:1902403 ! signal transduction involved in mitotic DNA integrity checkpoint
intersection_of: GO:0035556 ! intracellular signal transduction
intersection_of: part_of GO:0044773 ! mitotic DNA damage checkpoint
relationship: part_of GO:0044773 ! mitotic DNA damage checkpoint
created_by: jl
creation_date: 2013-09-12T12:07:20Z

[Term]
id: GO:1902403
name: signal transduction involved in mitotic DNA integrity checkpoint
namespace: biological_process
def: "Any intracellular signal transduction that is involved in mitotic DNA integrity checkpoint." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "intracellular signal transduction involved in mitotic cell cycle G2/M transition decatenation checkpoint" EXACT [GOC:TermGenie]
synonym: "intracellular signal transduction involved in topo II checkpoint" EXACT [GOC:TermGenie]
synonym: "intracellular signal transduction involved in topoisomerase II checkpoint" EXACT [GOC:TermGenie]
synonym: "intracellular signal transduction pathway involved in mitotic cell cycle G2/M transition decatenation checkpoint" NARROW [GOC:TermGenie]
synonym: "intracellular signal transduction pathway involved in mitotic DNA integrity checkpoint" NARROW [GOC:TermGenie]
synonym: "intracellular signal transduction pathway involved in topo II checkpoint" NARROW [GOC:TermGenie]
synonym: "intracellular signal transduction pathway involved in topoisomerase II checkpoint" NARROW [GOC:TermGenie]
synonym: "intracellular signaling cascade involved in mitotic cell cycle G2/M transition decatenation checkpoint" EXACT [GOC:TermGenie]
synonym: "intracellular signaling cascade involved in mitotic DNA integrity checkpoint" EXACT [GOC:TermGenie]
synonym: "intracellular signaling cascade involved in topo II checkpoint" EXACT [GOC:TermGenie]
synonym: "intracellular signaling cascade involved in topoisomerase II checkpoint" EXACT [GOC:TermGenie]
synonym: "intracellular signaling chain involved in mitotic cell cycle G2/M transition decatenation checkpoint" EXACT [GOC:TermGenie]
synonym: "intracellular signaling chain involved in mitotic DNA integrity checkpoint" EXACT [GOC:TermGenie]
synonym: "intracellular signaling chain involved in topo II checkpoint" EXACT [GOC:TermGenie]
synonym: "intracellular signaling chain involved in topoisomerase II checkpoint" EXACT [GOC:TermGenie]
synonym: "intracellular signaling pathway involved in mitotic cell cycle G2/M transition decatenation checkpoint" RELATED [GOC:TermGenie]
synonym: "intracellular signaling pathway involved in mitotic DNA integrity checkpoint" RELATED [GOC:TermGenie]
synonym: "intracellular signaling pathway involved in topo II checkpoint" RELATED [GOC:TermGenie]
synonym: "intracellular signaling pathway involved in topoisomerase II checkpoint" RELATED [GOC:TermGenie]
synonym: "signal transduction via intracellular signaling cascade involved in mitotic cell cycle G2/M transition decatenation checkpoint" RELATED [GOC:TermGenie]
synonym: "signal transduction via intracellular signaling cascade involved in mitotic DNA integrity checkpoint" RELATED [GOC:TermGenie]
synonym: "signal transduction via intracellular signaling cascade involved in topo II checkpoint" RELATED [GOC:TermGenie]
synonym: "signal transduction via intracellular signaling cascade involved in topoisomerase II checkpoint" RELATED [GOC:TermGenie]
synonym: "signal transmission via intracellular cascade involved in mitotic cell cycle G2/M transition decatenation checkpoint" NARROW [GOC:TermGenie]
synonym: "signal transmission via intracellular cascade involved in mitotic DNA integrity checkpoint" NARROW [GOC:TermGenie]
synonym: "signal transmission via intracellular cascade involved in topo II checkpoint" NARROW [GOC:TermGenie]
synonym: "signal transmission via intracellular cascade involved in topoisomerase II checkpoint" NARROW [GOC:TermGenie]
is_a: GO:0072401 ! signal transduction involved in DNA integrity checkpoint
is_a: GO:0072413 ! signal transduction involved in mitotic cell cycle checkpoint
intersection_of: GO:0035556 ! intracellular signal transduction
intersection_of: part_of GO:0044774 ! mitotic DNA integrity checkpoint
relationship: part_of GO:0044774 ! mitotic DNA integrity checkpoint
created_by: jl
creation_date: 2013-09-12T12:07:28Z

[Term]
id: GO:1902404
name: mitotic actomyosin contractile ring contraction
namespace: biological_process
def: "Any actomyosin contractile ring contraction that is involved in mitotic cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "cytokinesis, actomyosin ring contraction involved in mitotic cell cycle" EXACT [GOC:TermGenie]
is_a: GO:0000916 ! actomyosin contractile ring contraction
is_a: GO:1902410 ! mitotic cytokinetic process
intersection_of: GO:0000916 ! actomyosin contractile ring contraction
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0000281 ! mitotic cytokinesis
created_by: jl
creation_date: 2013-09-12T12:27:57Z

[Term]
id: GO:1902405
name: mitotic actomyosin contractile ring localization
namespace: biological_process
def: "Any actomyosin contractile ring localization that is involved in mitotic cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
is_a: GO:0032187 ! actomyosin contractile ring localization
is_a: GO:1902410 ! mitotic cytokinetic process
intersection_of: GO:0032187 ! actomyosin contractile ring localization
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0000281 ! mitotic cytokinesis
created_by: jl
creation_date: 2013-09-12T12:28:05Z

[Term]
id: GO:1902406
name: mitotic actomyosin contractile ring maintenance
namespace: biological_process
def: "Any actomyosin contractile ring maintenance that is involved in mitotic cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "contractile ring maintenance involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "cytokinesis, contractile ring maintenance, involved in cytokinesis during cell cycle involved in mitotic cell cycle" EXACT [GOC:TermGenie]
is_a: GO:0031566 ! actomyosin contractile ring maintenance
is_a: GO:1902410 ! mitotic cytokinetic process
intersection_of: GO:0031566 ! actomyosin contractile ring maintenance
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0000281 ! mitotic cytokinesis
created_by: jl
creation_date: 2013-09-12T12:28:14Z

[Term]
id: GO:1902407
name: assembly of actomyosin apparatus involved in mitotic cytokinesis
namespace: biological_process
def: "Any assembly of mitotic cytokinetic actomyosin apparatus." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "actomyosin apparatus assembly involved in cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "cytokinesis, formation of actomyosin apparatus involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "formation of actomyosin apparatus involved in cytokinesis involved in mitotic cell cycle" RELATED [GOC:TermGenie]
is_a: GO:0000912 ! assembly of actomyosin apparatus involved in cytokinesis
is_a: GO:1902410 ! mitotic cytokinetic process
intersection_of: GO:0000912 ! assembly of actomyosin apparatus involved in cytokinesis
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0000281 ! mitotic cytokinesis
created_by: jl
creation_date: 2013-09-12T12:28:22Z

[Term]
id: GO:1902408
name: mitotic cytokinesis, site selection
namespace: biological_process
def: "Any cytokinesis, site selection that is involved in mitotic cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "site selection involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "site selection involved in cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
is_a: GO:0007105 ! cytokinesis, site selection
is_a: GO:1902410 ! mitotic cytokinetic process
intersection_of: GO:0007105 ! cytokinesis, site selection
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0000281 ! mitotic cytokinesis
created_by: jl
creation_date: 2013-09-12T12:29:13Z

[Term]
id: GO:1902410
name: mitotic cytokinetic process
namespace: biological_process
def: "Any cytokinetic process that is involved in mitotic cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie]
is_a: GO:0032506 ! cytokinetic process
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0032506 ! cytokinetic process
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0000281 ! mitotic cytokinesis
relationship: part_of GO:0061640 ! cytoskeleton-dependent cytokinesis
created_by: jl
creation_date: 2013-09-12T12:29:36Z

[Term]
id: GO:1902412
name: regulation of mitotic cytokinesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitotic cytokinesis." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "regulation of cytokinesis after mitosis" EXACT [GOC:TermGenie]
is_a: GO:0007346 ! regulation of mitotic cell cycle
is_a: GO:0032465 ! regulation of cytokinesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000281 ! mitotic cytokinesis
relationship: regulates GO:0000281 ! mitotic cytokinesis
created_by: jl
creation_date: 2013-09-12T14:11:49Z

[Term]
id: GO:1902413
name: negative regulation of mitotic cytokinesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cytokinesis." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "down regulation of cytokinesis after mitosis" EXACT [GOC:TermGenie]
synonym: "down regulation of mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of cytokinesis after mitosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "downregulation of cytokinesis after mitosis" EXACT [GOC:TermGenie]
synonym: "downregulation of mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "inhibition of cytokinesis after mitosis" NARROW [GOC:TermGenie]
synonym: "inhibition of mitotic cytokinesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of cytokinesis after mitosis" EXACT [GOC:TermGenie]
is_a: GO:0032466 ! negative regulation of cytokinesis
is_a: GO:0045930 ! negative regulation of mitotic cell cycle
is_a: GO:1902412 ! regulation of mitotic cytokinesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000281 ! mitotic cytokinesis
relationship: negatively_regulates GO:0000281 ! mitotic cytokinesis
created_by: jl
creation_date: 2013-09-12T14:11:59Z

[Term]
id: GO:1902414
name: protein localization to cell junction
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a cell junction." [GOC:TermGenie, PMID:18332111]
synonym: "protein localisation in cell junction" EXACT [GOC:TermGenie]
synonym: "protein localisation to cell junction" EXACT [GOC:TermGenie]
synonym: "protein localization in cell junction" EXACT [GOC:TermGenie]
is_a: GO:0008104 ! protein localization
created_by: tb
creation_date: 2013-09-13T16:55:57Z

[Term]
id: GO:1902415
name: regulation of mRNA binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mRNA binding." [GOC:rb, GOC:TermGenie, PMID:22890846]
is_a: GO:0051098 ! regulation of binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003729 ! mRNA binding
relationship: regulates GO:0003729 ! mRNA binding
created_by: rb
creation_date: 2013-09-13T18:57:15Z

[Term]
id: GO:1902416
name: positive regulation of mRNA binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mRNA binding." [GOC:rb, GOC:TermGenie, PMID:22890846]
synonym: "activation of mRNA binding" NARROW [GOC:TermGenie]
synonym: "up regulation of mRNA binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of mRNA binding" EXACT [GOC:TermGenie]
synonym: "upregulation of mRNA binding" EXACT [GOC:TermGenie]
is_a: GO:0051099 ! positive regulation of binding
is_a: GO:1902415 ! regulation of mRNA binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003729 ! mRNA binding
relationship: positively_regulates GO:0003729 ! mRNA binding
created_by: rb
creation_date: 2013-09-13T18:57:24Z

[Term]
id: GO:1902417
name: (+)-abscisic acid D-glucopyranosyl ester transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of (+)-abscisic acid D-glucopyranosyl ester from one side of the membrane to the other." [GOC:TermGenie, PMID:24028845]
synonym: "ABA-GE transmembrane transporter activity" EXACT []
synonym: "abscisic acid glucosyl ester transmembrane transporter activity" EXACT []
is_a: GO:0042947 ! glucoside transmembrane transporter activity
relationship: part_of GO:1902418 ! (+)-abscisic acid D-glucopyranosyl ester transmembrane transport
created_by: tb
creation_date: 2013-09-16T22:37:11Z

[Term]
id: GO:1902418
name: (+)-abscisic acid D-glucopyranosyl ester transmembrane transport
namespace: biological_process
def: "The directed movement of (+)-abscisic acid D-glucopyranosyl ester across a membrane." [GOC:TermGenie, PMID:24028845]
synonym: "ABA-GE transmembrane transport" EXACT []
synonym: "abscisic acid glucosyl ester transmembrane transport" EXACT []
is_a: GO:0042946 ! glucoside transport
is_a: GO:0055085 ! transmembrane transport
created_by: tb
creation_date: 2013-09-16T22:37:20Z

[Term]
id: GO:1902419
name: detection of stimulus involved in Dma1-dependent checkpoint
namespace: biological_process
def: "Any detection of stimulus that is involved in Dma1-dependent checkpoint." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "detection of stimulus involved in SAC-independent checkpoint" EXACT [GOC:TermGenie]
synonym: "perception of stimulus involved in DMA1-dependent checkpoint" RELATED [GOC:TermGenie]
synonym: "perception of stimulus involved in SAC-independent checkpoint" RELATED [GOC:TermGenie]
synonym: "stimulus detection involved in DMA1-dependent checkpoint" EXACT [GOC:TermGenie]
synonym: "stimulus detection involved in SAC-independent checkpoint" EXACT [GOC:TermGenie]
synonym: "stimulus sensing involved in DMA1-dependent checkpoint" RELATED [GOC:TermGenie]
synonym: "stimulus sensing involved in SAC-independent checkpoint" RELATED [GOC:TermGenie]
is_a: GO:0072475 ! detection of stimulus involved in mitotic spindle checkpoint
intersection_of: GO:0051606 ! detection of stimulus
intersection_of: part_of GO:0044810 ! Dma1-dependent checkpoint
relationship: part_of GO:0044810 ! Dma1-dependent checkpoint
created_by: jl
creation_date: 2013-09-17T14:41:05Z

[Term]
id: GO:1902420
name: signal transduction involved in Dma1-dependent checkpoint
namespace: biological_process
def: "Any signal transduction that is involved in Dma1-dependent checkpoint." [GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "signal transduction involved in SAC-independent checkpoint" EXACT [GOC:TermGenie]
synonym: "signaling cascade involved in Dma1-dependent checkpoint" NARROW [GOC:TermGenie]
synonym: "signaling cascade involved in SAC-independent checkpoint" NARROW [GOC:TermGenie]
synonym: "signaling pathway involved in Dma1-dependent checkpoint" RELATED [GOC:TermGenie]
synonym: "signaling pathway involved in SAC-independent checkpoint" RELATED [GOC:TermGenie]
synonym: "signalling cascade involved in Dma1-dependent checkpoint" NARROW [GOC:TermGenie]
synonym: "signalling cascade involved in SAC-independent checkpoint" NARROW [GOC:TermGenie]
synonym: "signalling pathway involved in Dma1-dependent checkpoint" RELATED [GOC:TermGenie]
synonym: "signalling pathway involved in SAC-independent checkpoint" RELATED [GOC:TermGenie]
is_a: GO:0001100 ! negative regulation of exit from mitosis
is_a: GO:0023019 ! signal transduction involved in regulation of gene expression
is_a: GO:0032466 ! negative regulation of cytokinesis
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0007165 ! signal transduction
intersection_of: part_of GO:0044810 ! Dma1-dependent checkpoint
relationship: part_of GO:0044810 ! Dma1-dependent checkpoint
created_by: jl
creation_date: 2013-09-17T14:40:56Z

[Term]
id: GO:1902421
name: hydrogen metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving H2 (dihydrogen)." [GOC:mengo_curators, GOC:TermGenie, PMID:20395274, PMID:20692761]
synonym: "dihydrogen metabolism" EXACT [GOC:TermGenie]
synonym: "H2 metabolism" EXACT []
synonym: "molecular hydrogen metabolism" EXACT []
is_a: GO:0008152 ! metabolic process
created_by: jl
creation_date: 2013-09-18T14:34:23Z

[Term]
id: GO:1902422
name: hydrogen biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of H2 (dihydrogen)." [GOC:mengo_curators, GOC:TermGenie, PMID:20395274, PMID:20692761]
synonym: "dihydrogen synthesis" EXACT [GOC:jl]
synonym: "H2 biosynthesis" EXACT []
synonym: "hydrogen anabolism" EXACT [GOC:TermGenie]
synonym: "hydrogen biosynthesis" EXACT [GOC:TermGenie]
synonym: "hydrogen formation" EXACT [GOC:TermGenie]
synonym: "hydrogen generation" EXACT [GOC:jl]
synonym: "hydrogen production" EXACT []
synonym: "hydrogen synthesis" EXACT [GOC:TermGenie]
synonym: "molecular hydrogen biosynthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:1902421 ! hydrogen metabolic process
created_by: jl
creation_date: 2013-09-18T14:34:32Z

[Term]
id: GO:1902423
name: regulation of mitotic attachment of spindle microtubules to kinetochore
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation." [GOC:TermGenie, PMID:22065639]
synonym: "regulation of attachment of spindle microtubules to kinetochore during mitosis" RELATED [GOC:TermGenie]
synonym: "regulation of attachment of spindle microtubules to kinetochore involved in mitosis" EXACT [GOC:TermGenie]
synonym: "regulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation" EXACT []
synonym: "regulation of attachment of spindle microtubules to mitotic chromosome" EXACT [GOC:TermGenie]
synonym: "regulation of mitotic bipolar attachment" RELATED [GOC:TermGenie]
is_a: GO:0033047 ! regulation of mitotic sister chromatid segregation
is_a: GO:0051988 ! regulation of attachment of spindle microtubules to kinetochore
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051315 ! attachment of mitotic spindle microtubules to kinetochore
relationship: regulates GO:0051315 ! attachment of mitotic spindle microtubules to kinetochore
created_by: vw
creation_date: 2013-09-19T10:33:38Z

[Term]
id: GO:1902424
name: negative regulation of mitotic attachment of spindle microtubules to kinetochore
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation." [GOC:TermGenie, PMID:22065639]
synonym: "down regulation of attachment of spindle microtubules to kinetochore during mitosis" RELATED [GOC:TermGenie]
synonym: "down regulation of attachment of spindle microtubules to kinetochore involved in mitosis" EXACT [GOC:TermGenie]
synonym: "down regulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation" EXACT [GOC:TermGenie]
synonym: "down regulation of attachment of spindle microtubules to mitotic chromosome" EXACT [GOC:TermGenie]
synonym: "down regulation of mitotic bipolar attachment" RELATED [GOC:TermGenie]
synonym: "down-regulation of attachment of spindle microtubules to kinetochore during mitosis" RELATED [GOC:TermGenie]
synonym: "down-regulation of attachment of spindle microtubules to kinetochore involved in mitosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation" EXACT [GOC:TermGenie]
synonym: "down-regulation of attachment of spindle microtubules to mitotic chromosome" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitotic bipolar attachment" RELATED [GOC:TermGenie]
synonym: "downregulation of attachment of spindle microtubules to kinetochore during mitosis" RELATED [GOC:TermGenie]
synonym: "downregulation of attachment of spindle microtubules to kinetochore involved in mitosis" EXACT [GOC:TermGenie]
synonym: "downregulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation" EXACT [GOC:TermGenie]
synonym: "downregulation of attachment of spindle microtubules to mitotic chromosome" EXACT [GOC:TermGenie]
synonym: "downregulation of mitotic bipolar attachment" RELATED [GOC:TermGenie]
synonym: "inhibition of attachment of spindle microtubules to kinetochore during mitosis" RELATED [GOC:TermGenie]
synonym: "inhibition of attachment of spindle microtubules to kinetochore involved in mitosis" NARROW [GOC:TermGenie]
synonym: "inhibition of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation" NARROW [GOC:TermGenie]
synonym: "inhibition of attachment of spindle microtubules to mitotic chromosome" NARROW [GOC:TermGenie]
synonym: "inhibition of mitotic bipolar attachment" RELATED [GOC:TermGenie]
synonym: "negative regulation of attachment of spindle microtubules to kinetochore during mitosis" RELATED [GOC:TermGenie]
synonym: "negative regulation of attachment of spindle microtubules to kinetochore involved in mitosis" EXACT [GOC:TermGenie]
synonym: "negative regulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation" EXACT []
synonym: "negative regulation of attachment of spindle microtubules to mitotic chromosome" EXACT [GOC:TermGenie]
synonym: "negative regulation of mitotic bipolar attachment" RELATED [GOC:TermGenie]
is_a: GO:0033048 ! negative regulation of mitotic sister chromatid segregation
is_a: GO:0051986 ! negative regulation of attachment of spindle microtubules to kinetochore
is_a: GO:1902423 ! regulation of mitotic attachment of spindle microtubules to kinetochore
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051315 ! attachment of mitotic spindle microtubules to kinetochore
relationship: negatively_regulates GO:0051315 ! attachment of mitotic spindle microtubules to kinetochore
created_by: vw
creation_date: 2013-09-19T10:33:46Z

[Term]
id: GO:1902425
name: positive regulation of attachment of mitotic spindle microtubules to kinetochore
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation." [GOC:TermGenie, PMID:22065639]
synonym: "activation of attachment of spindle microtubules to kinetochore during mitosis" RELATED [GOC:TermGenie]
synonym: "activation of attachment of spindle microtubules to kinetochore involved in mitosis" NARROW [GOC:TermGenie]
synonym: "activation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation" NARROW [GOC:TermGenie]
synonym: "activation of attachment of spindle microtubules to mitotic chromosome" NARROW [GOC:TermGenie]
synonym: "activation of mitotic bipolar attachment" RELATED [GOC:TermGenie]
synonym: "positive regulation of attachment of spindle microtubules to kinetochore during mitosis" RELATED [GOC:TermGenie]
synonym: "positive regulation of attachment of spindle microtubules to kinetochore involved in mitosis" EXACT [GOC:TermGenie]
synonym: "positive regulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation" EXACT []
synonym: "positive regulation of attachment of spindle microtubules to mitotic chromosome" EXACT [GOC:TermGenie]
synonym: "positive regulation of mitotic bipolar attachment" RELATED [GOC:TermGenie]
synonym: "up regulation of attachment of spindle microtubules to kinetochore during mitosis" RELATED [GOC:TermGenie]
synonym: "up regulation of attachment of spindle microtubules to kinetochore involved in mitosis" EXACT [GOC:TermGenie]
synonym: "up regulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation" EXACT [GOC:TermGenie]
synonym: "up regulation of attachment of spindle microtubules to mitotic chromosome" EXACT [GOC:TermGenie]
synonym: "up regulation of mitotic bipolar attachment" RELATED [GOC:TermGenie]
synonym: "up-regulation of attachment of spindle microtubules to kinetochore during mitosis" RELATED [GOC:TermGenie]
synonym: "up-regulation of attachment of spindle microtubules to kinetochore involved in mitosis" EXACT [GOC:TermGenie]
synonym: "up-regulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation" EXACT [GOC:TermGenie]
synonym: "up-regulation of attachment of spindle microtubules to mitotic chromosome" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitotic bipolar attachment" RELATED [GOC:TermGenie]
synonym: "upregulation of attachment of spindle microtubules to kinetochore during mitosis" RELATED [GOC:TermGenie]
synonym: "upregulation of attachment of spindle microtubules to kinetochore involved in mitosis" EXACT [GOC:TermGenie]
synonym: "upregulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation" EXACT [GOC:TermGenie]
synonym: "upregulation of attachment of spindle microtubules to mitotic chromosome" EXACT [GOC:TermGenie]
synonym: "upregulation of mitotic bipolar attachment" RELATED [GOC:TermGenie]
is_a: GO:0045840 ! positive regulation of mitotic nuclear division
is_a: GO:0051987 ! positive regulation of attachment of spindle microtubules to kinetochore
is_a: GO:1902423 ! regulation of mitotic attachment of spindle microtubules to kinetochore
is_a: GO:2001252 ! positive regulation of chromosome organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051315 ! attachment of mitotic spindle microtubules to kinetochore
relationship: positively_regulates GO:0051315 ! attachment of mitotic spindle microtubules to kinetochore
created_by: vw
creation_date: 2013-09-19T10:33:55Z

[Term]
id: GO:1902426
name: negative regulation of mitotic spindle assembly checkpoint
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic spindle assembly checkpoint." [GOC:dph, GOC:TermGenie, PMID:19075002]
synonym: "down regulation of Mad2-dependent checkpoint" NARROW [GOC:TermGenie]
synonym: "down regulation of mitotic cell cycle spindle assembly checkpoint" EXACT [GOC:TermGenie]
synonym: "down regulation of mitotic spindle assembly checkpoint" EXACT [GOC:TermGenie]
synonym: "down-regulation of Mad2-dependent checkpoint" NARROW [GOC:TermGenie]
synonym: "down-regulation of mitotic cell cycle spindle assembly checkpoint" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitotic spindle assembly checkpoint" EXACT [GOC:TermGenie]
synonym: "downregulation of Mad2-dependent checkpoint" NARROW [GOC:TermGenie]
synonym: "downregulation of mitotic cell cycle spindle assembly checkpoint" EXACT [GOC:TermGenie]
synonym: "downregulation of mitotic spindle assembly checkpoint" EXACT [GOC:TermGenie]
synonym: "inhibition of Mad2-dependent checkpoint" NARROW [GOC:TermGenie]
synonym: "inhibition of mitotic cell cycle spindle assembly checkpoint" NARROW [GOC:TermGenie]
synonym: "inhibition of mitotic spindle assembly checkpoint" NARROW [GOC:TermGenie]
synonym: "negative regulation of Mad2-dependent checkpoint" NARROW [GOC:TermGenie]
synonym: "negative regulation of mitotic cell cycle spindle assembly checkpoint" EXACT [GOC:TermGenie]
is_a: GO:0045842 ! positive regulation of mitotic metaphase/anaphase transition
is_a: GO:0045930 ! negative regulation of mitotic cell cycle
is_a: GO:0090233 ! negative regulation of spindle checkpoint
is_a: GO:0090266 ! regulation of mitotic cell cycle spindle assembly checkpoint
is_a: GO:1904668 ! positive regulation of ubiquitin protein ligase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007094 ! mitotic spindle assembly checkpoint
relationship: negatively_regulates GO:0007094 ! mitotic spindle assembly checkpoint
created_by: dph
creation_date: 2013-09-20T18:42:07Z

[Term]
id: GO:1902427
name: regulation of water channel activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of water channel activity." [GOC:nhn, GOC:TermGenie, PMID:22095752]
synonym: "regulation of aquaporin" NARROW [GOC:TermGenie]
synonym: "regulation of aquaporin permeability" NARROW [PMID:22095752]
is_a: GO:0022898 ! regulation of transmembrane transporter activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0015250 ! water channel activity
relationship: regulates GO:0015250 ! water channel activity
created_by: bf
creation_date: 2013-09-23T12:56:31Z

[Term]
id: GO:1902428
name: negative regulation of water channel activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of water channel activity." [GOC:TermGenie]
synonym: "down regulation of aquaporin" NARROW [GOC:TermGenie]
synonym: "down regulation of water channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of aquaporin" NARROW [GOC:TermGenie]
synonym: "down-regulation of water channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of aquaporin" NARROW [GOC:TermGenie]
synonym: "downregulation of water channel activity" EXACT [GOC:TermGenie]
synonym: "inhibition of aquaporin" NARROW [GOC:TermGenie]
synonym: "inhibition of water channel activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of aquaporin" NARROW [GOC:TermGenie]
is_a: GO:0032410 ! negative regulation of transporter activity
is_a: GO:0034763 ! negative regulation of transmembrane transport
is_a: GO:1902427 ! regulation of water channel activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0015250 ! water channel activity
relationship: negatively_regulates GO:0015250 ! water channel activity
created_by: bf
creation_date: 2013-09-23T12:56:40Z

[Term]
id: GO:1902429
name: positive regulation of water channel activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of water channel activity." [GOC:nhn, GOC:TermGenie, PMID:22095752]
synonym: "activation of aquaporin" NARROW [GOC:TermGenie]
synonym: "activation of water channel activity" NARROW [GOC:TermGenie]
synonym: "aquaporin activation" NARROW [PMID:22095752]
synonym: "positive regulation of aquaporin" NARROW [GOC:TermGenie]
synonym: "up regulation of aquaporin" NARROW [GOC:TermGenie]
synonym: "up regulation of water channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of aquaporin" NARROW [GOC:TermGenie]
synonym: "up-regulation of water channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of aquaporin" NARROW [GOC:TermGenie]
synonym: "upregulation of water channel activity" EXACT [GOC:TermGenie]
is_a: GO:0032411 ! positive regulation of transporter activity
is_a: GO:0034764 ! positive regulation of transmembrane transport
is_a: GO:1902427 ! regulation of water channel activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0015250 ! water channel activity
relationship: positively_regulates GO:0015250 ! water channel activity
created_by: bf
creation_date: 2013-09-23T12:56:49Z

[Term]
id: GO:1902430
name: negative regulation of beta-amyloid formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of beta-amyloid formation." [GOC:hjd, GOC:TermGenie, PMID:22992957]
synonym: "down regulation of beta-amyloid formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of beta-amyloid formation" EXACT [GOC:TermGenie]
synonym: "downregulation of beta-amyloid formation" EXACT [GOC:TermGenie]
synonym: "inhibition of beta-amyloid formation" NARROW [GOC:TermGenie]
is_a: GO:0034249 ! negative regulation of cellular amide metabolic process
is_a: GO:1902003 ! regulation of beta-amyloid formation
is_a: GO:1902992 ! negative regulation of amyloid precursor protein catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034205 ! beta-amyloid formation
relationship: negatively_regulates GO:0034205 ! beta-amyloid formation
created_by: hjd
creation_date: 2013-09-25T17:41:01Z

[Term]
id: GO:1902431
name: uracil import into cell
namespace: biological_process
def: "The directed movement of uracil from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [GOC:al, GOC:TermGenie]
is_a: GO:0015857 ! uracil transport
is_a: GO:0098657 ! import into cell
created_by: tb
creation_date: 2013-09-27T17:54:23Z

[Term]
id: GO:1902432
name: protein localization to barrier septum
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a barrier septum." [GOC:TermGenie, PMID:9367977]
synonym: "protein localisation in barrier septum" EXACT [GOC:TermGenie]
synonym: "protein localisation to barrier septum" EXACT [GOC:TermGenie]
synonym: "protein localization in barrier septum" EXACT [GOC:TermGenie]
is_a: GO:0034613 ! cellular protein localization
created_by: mah
creation_date: 2013-09-30T14:29:51Z

[Term]
id: GO:1902433
name: positive regulation of water channel activity involved in maintenance of lens transparency
namespace: biological_process
def: "Any positive regulation of water channel activity that is involved in maintenance of lens transparency." [GOC:nhn, GOC:TermGenie, PMID:22095752]
synonym: "activation of aquaporin involved in maintenance of lens transparency" NARROW [GOC:TermGenie]
synonym: "activation of aquaporin involved in maintenance of ocular lens transparency" NARROW [GOC:TermGenie]
synonym: "activation of aquaporin involved in preservation of lens transparency" NARROW [GOC:TermGenie]
synonym: "activation of water channel activity involved in maintenance of lens transparency" NARROW [GOC:TermGenie]
synonym: "activation of water channel activity involved in maintenance of ocular lens transparency" NARROW [GOC:TermGenie]
synonym: "activation of water channel activity involved in preservation of lens transparency" NARROW [GOC:TermGenie]
synonym: "aquaporin activation involved in maintenance of lens transparency" NARROW [GOC:TermGenie]
synonym: "aquaporin activation involved in maintenance of ocular lens transparency" NARROW [GOC:TermGenie]
synonym: "aquaporin activation involved in preservation of lens transparency" NARROW [GOC:TermGenie]
synonym: "positive regulation of aquaporin involved in maintenance of lens transparency" NARROW [GOC:TermGenie]
synonym: "positive regulation of aquaporin involved in maintenance of ocular lens transparency" NARROW [GOC:TermGenie]
synonym: "positive regulation of aquaporin involved in preservation of lens transparency" NARROW [GOC:TermGenie]
synonym: "positive regulation of water channel activity involved in maintenance of ocular lens transparency" EXACT [GOC:TermGenie]
synonym: "positive regulation of water channel activity involved in preservation of lens transparency" EXACT [GOC:TermGenie]
synonym: "up regulation of aquaporin involved in maintenance of lens transparency" NARROW [GOC:TermGenie]
synonym: "up regulation of aquaporin involved in maintenance of ocular lens transparency" NARROW [GOC:TermGenie]
synonym: "up regulation of aquaporin involved in preservation of lens transparency" NARROW [GOC:TermGenie]
synonym: "up regulation of water channel activity involved in maintenance of lens transparency" EXACT [GOC:TermGenie]
synonym: "up regulation of water channel activity involved in maintenance of ocular lens transparency" EXACT [GOC:TermGenie]
synonym: "up regulation of water channel activity involved in preservation of lens transparency" EXACT [GOC:TermGenie]
synonym: "up-regulation of aquaporin involved in maintenance of lens transparency" NARROW [GOC:TermGenie]
synonym: "up-regulation of aquaporin involved in maintenance of ocular lens transparency" NARROW [GOC:TermGenie]
synonym: "up-regulation of aquaporin involved in preservation of lens transparency" NARROW [GOC:TermGenie]
synonym: "up-regulation of water channel activity involved in maintenance of lens transparency" EXACT [GOC:TermGenie]
synonym: "up-regulation of water channel activity involved in maintenance of ocular lens transparency" EXACT [GOC:TermGenie]
synonym: "up-regulation of water channel activity involved in preservation of lens transparency" EXACT [GOC:TermGenie]
synonym: "upregulation of aquaporin involved in maintenance of lens transparency" NARROW [GOC:TermGenie]
synonym: "upregulation of aquaporin involved in maintenance of ocular lens transparency" NARROW [GOC:TermGenie]
synonym: "upregulation of aquaporin involved in preservation of lens transparency" NARROW [GOC:TermGenie]
synonym: "upregulation of water channel activity involved in maintenance of lens transparency" EXACT [GOC:TermGenie]
synonym: "upregulation of water channel activity involved in maintenance of ocular lens transparency" EXACT [GOC:TermGenie]
synonym: "upregulation of water channel activity involved in preservation of lens transparency" EXACT [GOC:TermGenie]
is_a: GO:1902429 ! positive regulation of water channel activity
intersection_of: GO:1902429 ! positive regulation of water channel activity
intersection_of: part_of GO:0036438 ! maintenance of lens transparency
relationship: part_of GO:0036438 ! maintenance of lens transparency
created_by: bf
creation_date: 2013-10-02T12:58:00Z

[Term]
id: GO:1902434
name: sulfate import into cell
namespace: biological_process
def: "The directed movement of sulfate from outside of a cell into the intracellular region of a cell." [GOC:TermGenie, PMID:14723223]
synonym: "sulphate import into cell" EXACT []
is_a: GO:0008272 ! sulfate transport
created_by: mah
creation_date: 2013-10-07T14:12:38Z

[Term]
id: GO:1902435
name: regulation of male mating behavior
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of male mating behavior." [GOC:TermGenie, PMID:24089208]
is_a: GO:0043900 ! regulation of multi-organism process
is_a: GO:0050795 ! regulation of behavior
is_a: GO:0051239 ! regulation of multicellular organismal process
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060179 ! male mating behavior
relationship: regulates GO:0060179 ! male mating behavior
created_by: mm2
creation_date: 2013-10-09T15:49:56Z

[Term]
id: GO:1902436
name: negative regulation of male mating behavior
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of male mating behavior." [GOC:TermGenie, PMID:24089208]
synonym: "down regulation of male mating behavior" EXACT [GOC:TermGenie]
synonym: "down-regulation of male mating behavior" EXACT [GOC:TermGenie]
synonym: "downregulation of male mating behavior" EXACT [GOC:TermGenie]
synonym: "inhibition of male mating behavior" NARROW [GOC:TermGenie]
is_a: GO:0043901 ! negative regulation of multi-organism process
is_a: GO:0048521 ! negative regulation of behavior
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1902435 ! regulation of male mating behavior
is_a: GO:2000242 ! negative regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060179 ! male mating behavior
relationship: negatively_regulates GO:0060179 ! male mating behavior
created_by: mm2
creation_date: 2013-10-09T15:50:05Z

[Term]
id: GO:1902437
name: positive regulation of male mating behavior
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of male mating behavior." [GOC:TermGenie, PMID:24089208]
synonym: "activation of male mating behavior" NARROW [GOC:TermGenie]
synonym: "up regulation of male mating behavior" EXACT [GOC:TermGenie]
synonym: "up-regulation of male mating behavior" EXACT [GOC:TermGenie]
synonym: "upregulation of male mating behavior" EXACT [GOC:TermGenie]
is_a: GO:0043902 ! positive regulation of multi-organism process
is_a: GO:0048520 ! positive regulation of behavior
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1902435 ! regulation of male mating behavior
is_a: GO:2000243 ! positive regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060179 ! male mating behavior
relationship: positively_regulates GO:0060179 ! male mating behavior
created_by: mm2
creation_date: 2013-10-09T15:50:14Z

[Term]
id: GO:1902438
name: response to vanadate(3-)
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vanadate(3-) stimulus." [GOC:di, GOC:TermGenie, PMID:7489911]
is_a: GO:0010035 ! response to inorganic substance
is_a: GO:1901700 ! response to oxygen-containing compound
is_a: GO:1990267 ! response to transition metal nanoparticle
created_by: di
creation_date: 2013-10-10T10:50:21Z

[Term]
id: GO:1902439
name: cellular response to vanadate(3-)
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vanadate(3-) stimulus." [GOC:di, GOC:TermGenie, PMID:7489911]
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1902438 ! response to vanadate(3-)
created_by: di
creation_date: 2013-10-10T10:50:30Z

[Term]
id: GO:1902440
name: protein localization to mitotic spindle pole body
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a mitotic spindle pole body." [GOC:TermGenie, PMID:22438582]
synonym: "protein localisation in mitotic spindle pole body" EXACT [GOC:TermGenie]
synonym: "protein localisation to mitotic spindle pole body" EXACT [GOC:TermGenie]
synonym: "protein localization in mitotic spindle pole body" EXACT [GOC:TermGenie]
is_a: GO:0071988 ! protein localization to spindle pole body
is_a: GO:1902480 ! protein localization to mitotic spindle
created_by: mah
creation_date: 2013-10-10T14:44:55Z

[Term]
id: GO:1902441
name: protein localization to meiotic spindle pole body
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a meiotic spindle pole body." [GOC:TermGenie, PMID:22438582]
synonym: "protein localisation in meiotic spindle pole body" EXACT [GOC:TermGenie]
synonym: "protein localisation to meiotic spindle pole body" EXACT [GOC:TermGenie]
synonym: "protein localization in meiotic spindle pole body" EXACT [GOC:TermGenie]
is_a: GO:0022414 ! reproductive process
is_a: GO:0071988 ! protein localization to spindle pole body
relationship: part_of GO:1990395 ! meiotic spindle pole body organization
created_by: mah
creation_date: 2013-10-10T14:45:04Z

[Term]
id: GO:1902442
name: regulation of ripoptosome assembly involved in necroptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ripoptosome assembly involved in a necroptotic process." [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:21052097]
synonym: "regulation of ripoptosome assembly involved in necroptosis" NARROW []
is_a: GO:0043254 ! regulation of protein complex assembly
is_a: GO:0060544 ! regulation of necroptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1901026 ! ripoptosome assembly involved in necroptotic process
relationship: regulates GO:1901026 ! ripoptosome assembly involved in necroptotic process
created_by: dph
creation_date: 2013-10-10T17:51:33Z

[Term]
id: GO:1902443
name: negative regulation of ripoptosome assembly involved in necroptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ripoptosome assembly involved in a necroptotic process." [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:21052097]
synonym: "down regulation of ripoptosome assembly involved in necroptosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of ripoptosome assembly involved in necroptosis" EXACT [GOC:TermGenie]
synonym: "downregulation of ripoptosome assembly involved in necroptosis" EXACT [GOC:TermGenie]
synonym: "inhibition of ripoptosome assembly involved in necroptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of ripoptosome assembly involved in necroptosis" NARROW []
is_a: GO:0031333 ! negative regulation of protein complex assembly
is_a: GO:0060546 ! negative regulation of necroptotic process
is_a: GO:1902442 ! regulation of ripoptosome assembly involved in necroptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1901026 ! ripoptosome assembly involved in necroptotic process
relationship: negatively_regulates GO:1901026 ! ripoptosome assembly involved in necroptotic process
created_by: dph
creation_date: 2013-10-10T17:51:41Z

[Term]
id: GO:1902444
name: riboflavin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with riboflavin." [GOC:TermGenie, PMID:12083520]
is_a: GO:0043168 ! anion binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding
created_by: al
creation_date: 2013-10-11T08:44:52Z

[Term]
id: GO:1902445
name: regulation of mitochondrial membrane permeability involved in programmed necrotic cell death
namespace: biological_process
def: "Any regulation of mitochondrial membrane permeability that is involved in programmed necrotic cell death." [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:22493254]
synonym: "regulation of transport across mitochondrial membrane involved in programmed necrotic cell death" EXACT [GOC:TermGenie]
is_a: GO:0046902 ! regulation of mitochondrial membrane permeability
intersection_of: GO:0046902 ! regulation of mitochondrial membrane permeability
intersection_of: part_of GO:0097300 ! programmed necrotic cell death
relationship: part_of GO:0097300 ! programmed necrotic cell death
created_by: dph
creation_date: 2013-10-11T13:11:20Z

[Term]
id: GO:1902446
name: regulation of shade avoidance
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of shade avoidance." [GOC:TermGenie, PMID:23763263]
is_a: GO:2000030 ! regulation of response to red or far red light
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009641 ! shade avoidance
relationship: regulates GO:0009641 ! shade avoidance
created_by: dhl
creation_date: 2013-10-15T21:04:36Z

[Term]
id: GO:1902447
name: negative regulation of shade avoidance
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of shade avoidance." [GOC:TermGenie, PMID:23763263]
synonym: "down regulation of shade avoidance" EXACT [GOC:TermGenie]
synonym: "down-regulation of shade avoidance" EXACT [GOC:TermGenie]
synonym: "downregulation of shade avoidance" EXACT [GOC:TermGenie]
synonym: "inhibition of shade avoidance" NARROW [GOC:TermGenie]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1902446 ! regulation of shade avoidance
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009641 ! shade avoidance
relationship: negatively_regulates GO:0009641 ! shade avoidance
created_by: dhl
creation_date: 2013-10-15T21:04:51Z

[Term]
id: GO:1902448
name: positive regulation of shade avoidance
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of shade avoidance." [GOC:TermGenie, PMID:23763263]
synonym: "activation of shade avoidance" NARROW [GOC:TermGenie]
synonym: "up regulation of shade avoidance" EXACT [GOC:TermGenie]
synonym: "up-regulation of shade avoidance" EXACT [GOC:TermGenie]
synonym: "upregulation of shade avoidance" EXACT [GOC:TermGenie]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1902446 ! regulation of shade avoidance
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009641 ! shade avoidance
relationship: positively_regulates GO:0009641 ! shade avoidance
created_by: dhl
creation_date: 2013-10-15T21:05:00Z

[Term]
id: GO:1902449
name: regulation of ATP-dependent DNA helicase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ATP-dependent DNA helicase activity." [GOC:rb, GOC:TermGenie, PMID:13679365]
is_a: GO:0033044 ! regulation of chromosome organization
is_a: GO:0043462 ! regulation of ATPase activity
is_a: GO:0051052 ! regulation of DNA metabolic process
is_a: GO:0051095 ! regulation of helicase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004003 ! ATP-dependent DNA helicase activity
relationship: regulates GO:0004003 ! ATP-dependent DNA helicase activity
created_by: rb
creation_date: 2013-10-15T21:19:52Z

[Term]
id: GO:1902450
name: negative regulation of ATP-dependent DNA helicase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ATP-dependent DNA helicase activity." [GOC:rb, GOC:TermGenie, PMID:13679365]
synonym: "down regulation of ATP-dependent DNA helicase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of ATP-dependent DNA helicase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of ATP-dependent DNA helicase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of ATP-dependent DNA helicase activity" NARROW [GOC:TermGenie]
is_a: GO:0032780 ! negative regulation of ATPase activity
is_a: GO:0051053 ! negative regulation of DNA metabolic process
is_a: GO:0051097 ! negative regulation of helicase activity
is_a: GO:1902449 ! regulation of ATP-dependent DNA helicase activity
is_a: GO:2001251 ! negative regulation of chromosome organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004003 ! ATP-dependent DNA helicase activity
relationship: negatively_regulates GO:0004003 ! ATP-dependent DNA helicase activity
created_by: rb
creation_date: 2013-10-15T21:20:01Z

[Term]
id: GO:1902451
name: positive regulation of ATP-dependent DNA helicase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ATP-dependent DNA helicase activity." [GOC:rb, GOC:TermGenie, PMID:13679365]
synonym: "activation of ATP-dependent DNA helicase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of ATP-dependent DNA helicase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of ATP-dependent DNA helicase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of ATP-dependent DNA helicase activity" EXACT [GOC:TermGenie]
is_a: GO:0032781 ! positive regulation of ATPase activity
is_a: GO:0051054 ! positive regulation of DNA metabolic process
is_a: GO:0051096 ! positive regulation of helicase activity
is_a: GO:1902449 ! regulation of ATP-dependent DNA helicase activity
is_a: GO:2001252 ! positive regulation of chromosome organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004003 ! ATP-dependent DNA helicase activity
relationship: positively_regulates GO:0004003 ! ATP-dependent DNA helicase activity
created_by: rb
creation_date: 2013-10-15T21:20:10Z

[Term]
id: GO:1902455
name: negative regulation of stem cell population maintenance
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of stem cell population maintenance." [GOC:hjd, GOC:TermGenie, PMID:22969033]
synonym: "down regulation of maintenance of pluripotency" RELATED [GOC:TermGenie]
synonym: "down regulation of stem cell maintenance" EXACT [GOC:TermGenie]
synonym: "down-regulation of maintenance of pluripotency" RELATED [GOC:TermGenie]
synonym: "down-regulation of stem cell maintenance" EXACT [GOC:TermGenie]
synonym: "downregulation of maintenance of pluripotency" RELATED [GOC:TermGenie]
synonym: "downregulation of stem cell maintenance" EXACT [GOC:TermGenie]
synonym: "inhibition of maintenance of pluripotency" RELATED [GOC:TermGenie]
synonym: "inhibition of stem cell maintenance" NARROW [GOC:TermGenie]
synonym: "negative regulation of maintenance of pluripotency" RELATED [GOC:TermGenie]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000036 ! regulation of stem cell population maintenance
is_a: GO:2000737 ! negative regulation of stem cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019827 ! stem cell population maintenance
relationship: negatively_regulates GO:0019827 ! stem cell population maintenance
created_by: cjmungall
creation_date: 2013-10-16T22:19:17Z

[Term]
id: GO:1902456
name: regulation of stomatal opening
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of stomatal opening." [GOC:TermGenie, PMID:23766366]
is_a: GO:0010119 ! regulation of stomatal movement
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990069 ! stomatal opening
relationship: regulates GO:1990069 ! stomatal opening
created_by: tb
creation_date: 2013-10-16T22:25:06Z

[Term]
id: GO:1902457
name: negative regulation of stomatal opening
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of stomatal opening." [GOC:TermGenie, PMID:23766366]
synonym: "down regulation of stomatal opening" EXACT [GOC:TermGenie]
synonym: "down-regulation of stomatal opening" EXACT [GOC:TermGenie]
synonym: "downregulation of stomatal opening" EXACT [GOC:TermGenie]
synonym: "inhibition of stomatal opening" NARROW [GOC:TermGenie]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:1902456 ! regulation of stomatal opening
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990069 ! stomatal opening
relationship: negatively_regulates GO:1990069 ! stomatal opening
created_by: tb
creation_date: 2013-10-16T22:25:22Z

[Term]
id: GO:1902458
name: positive regulation of stomatal opening
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of stomatal opening." [GOC:TermGenie, PMID:23766366]
synonym: "activation of stomatal opening" NARROW [GOC:TermGenie]
synonym: "up regulation of stomatal opening" EXACT [GOC:TermGenie]
synonym: "up-regulation of stomatal opening" EXACT [GOC:TermGenie]
synonym: "upregulation of stomatal opening" EXACT [GOC:TermGenie]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:1902456 ! regulation of stomatal opening
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990069 ! stomatal opening
relationship: positively_regulates GO:1990069 ! stomatal opening
created_by: tb
creation_date: 2013-10-16T22:25:33Z

[Term]
id: GO:1902459
name: positive regulation of stem cell population maintenance
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of stem cell population maintenance." [GOC:hjd, GOC:TermGenie, PMID:22969033]
synonym: "activation of maintenance of pluripotency" RELATED [GOC:TermGenie]
synonym: "activation of stem cell maintenance" NARROW [GOC:TermGenie]
synonym: "positive regulation of maintenance of pluripotency" RELATED [GOC:TermGenie]
synonym: "up regulation of maintenance of pluripotency" RELATED [GOC:TermGenie]
synonym: "up regulation of stem cell maintenance" EXACT [GOC:TermGenie]
synonym: "up-regulation of maintenance of pluripotency" RELATED [GOC:TermGenie]
synonym: "up-regulation of stem cell maintenance" EXACT [GOC:TermGenie]
synonym: "upregulation of maintenance of pluripotency" RELATED [GOC:TermGenie]
synonym: "upregulation of stem cell maintenance" EXACT [GOC:TermGenie]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000036 ! regulation of stem cell population maintenance
is_a: GO:2000738 ! positive regulation of stem cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0019827 ! stem cell population maintenance
relationship: positively_regulates GO:0019827 ! stem cell population maintenance
created_by: cjmungall
creation_date: 2013-10-16T22:27:47Z

[Term]
id: GO:1902460
name: regulation of mesenchymal stem cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesenchymal stem cell proliferation." [GOC:pm, GOC:TermGenie, PMID:18672106]
synonym: "regulation of MSC proliferation" EXACT [GOC:TermGenie]
is_a: GO:0072091 ! regulation of stem cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097168 ! mesenchymal stem cell proliferation
relationship: regulates GO:0097168 ! mesenchymal stem cell proliferation
created_by: pm
creation_date: 2013-10-22T10:01:00Z

[Term]
id: GO:1902461
name: negative regulation of mesenchymal stem cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal stem cell proliferation." [GOC:pm, GOC:TermGenie, PMID:18672106]
synonym: "down regulation of mesenchymal stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "down regulation of MSC proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of mesenchymal stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of MSC proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of mesenchymal stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of MSC proliferation" EXACT [GOC:TermGenie]
synonym: "inhibition of mesenchymal stem cell proliferation" NARROW [GOC:TermGenie]
synonym: "inhibition of MSC proliferation" NARROW [GOC:TermGenie]
synonym: "negative regulation of MSC proliferation" EXACT [GOC:TermGenie]
is_a: GO:1902460 ! regulation of mesenchymal stem cell proliferation
is_a: GO:2000647 ! negative regulation of stem cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097168 ! mesenchymal stem cell proliferation
relationship: negatively_regulates GO:0097168 ! mesenchymal stem cell proliferation
created_by: pm
creation_date: 2013-10-22T10:01:08Z

[Term]
id: GO:1902462
name: positive regulation of mesenchymal stem cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mesenchymal stem cell proliferation." [GOC:pm, GOC:TermGenie, PMID:18672106]
synonym: "activation of mesenchymal stem cell proliferation" NARROW [GOC:TermGenie]
synonym: "activation of MSC proliferation" NARROW [GOC:TermGenie]
synonym: "positive regulation of MSC proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of mesenchymal stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of MSC proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of mesenchymal stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of MSC proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of mesenchymal stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of MSC proliferation" EXACT [GOC:TermGenie]
is_a: GO:1902460 ! regulation of mesenchymal stem cell proliferation
is_a: GO:2000648 ! positive regulation of stem cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097168 ! mesenchymal stem cell proliferation
relationship: positively_regulates GO:0097168 ! mesenchymal stem cell proliferation
created_by: pm
creation_date: 2013-10-22T10:01:17Z

[Term]
id: GO:1902463
name: protein localization to cell leading edge
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a cell leading edge." [GOC:lb, GOC:TermGenie, PMID:21543326]
synonym: "protein localisation in cell leading edge" EXACT [GOC:TermGenie]
synonym: "protein localisation to cell leading edge" EXACT [GOC:TermGenie]
synonym: "protein localization in cell leading edge" EXACT [GOC:TermGenie]
is_a: GO:0034613 ! cellular protein localization
created_by: jl
creation_date: 2013-10-22T12:36:07Z

[Term]
id: GO:1902464
name: regulation of histone H3-K27 trimethylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of histone H3-K27 trimethylation." [GOC:TermGenie, PMID:19270745]
is_a: GO:0061085 ! regulation of histone H3-K27 methylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0098532 ! histone H3-K27 trimethylation
relationship: regulates GO:0098532 ! histone H3-K27 trimethylation
created_by: krc
creation_date: 2013-10-22T14:58:55Z

[Term]
id: GO:1902465
name: negative regulation of histone H3-K27 trimethylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K27 trimethylation." [GOC:TermGenie, PMID:19270745]
synonym: "down regulation of histone H3-K27 trimethylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of histone H3-K27 trimethylation" EXACT [GOC:TermGenie]
synonym: "downregulation of histone H3-K27 trimethylation" EXACT [GOC:TermGenie]
synonym: "inhibition of histone H3-K27 trimethylation" NARROW [GOC:TermGenie]
is_a: GO:0061086 ! negative regulation of histone H3-K27 methylation
is_a: GO:1902464 ! regulation of histone H3-K27 trimethylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0098532 ! histone H3-K27 trimethylation
relationship: negatively_regulates GO:0098532 ! histone H3-K27 trimethylation
created_by: krc
creation_date: 2013-10-22T14:59:04Z

[Term]
id: GO:1902466
name: positive regulation of histone H3-K27 trimethylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of histone H3-K27 trimethylation." [GOC:TermGenie, PMID:19270745]
synonym: "activation of histone H3-K27 trimethylation" NARROW [GOC:TermGenie]
synonym: "up regulation of histone H3-K27 trimethylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of histone H3-K27 trimethylation" EXACT [GOC:TermGenie]
synonym: "upregulation of histone H3-K27 trimethylation" EXACT [GOC:TermGenie]
is_a: GO:0061087 ! positive regulation of histone H3-K27 methylation
is_a: GO:1902464 ! regulation of histone H3-K27 trimethylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0098532 ! histone H3-K27 trimethylation
relationship: positively_regulates GO:0098532 ! histone H3-K27 trimethylation
created_by: krc
creation_date: 2013-10-22T14:59:19Z

[Term]
id: GO:1902471
name: regulation of mitotic actomyosin contractile ring localization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitotic actomyosin contractile ring localization." [GOC:TermGenie, PMID:19959363, PMID:21246752, PMID:22786806]
is_a: GO:1901648 ! regulation of actomyosin contractile ring localization
is_a: GO:1903436 ! regulation of mitotic cytokinetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1902405 ! mitotic actomyosin contractile ring localization
relationship: regulates GO:1902405 ! mitotic actomyosin contractile ring localization
created_by: mah
creation_date: 2013-10-24T14:20:03Z

[Term]
id: GO:1902472
name: regulation of mitotic cytokinesis, site selection
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitotic cytokinesis, site selection." [GOC:TermGenie, PMID:19959363, PMID:21246752, PMID:22786806]
is_a: GO:1903436 ! regulation of mitotic cytokinetic process
is_a: GO:2000073 ! regulation of cytokinesis, site selection
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1902408 ! mitotic cytokinesis, site selection
relationship: regulates GO:1902408 ! mitotic cytokinesis, site selection
created_by: mah
creation_date: 2013-10-24T14:20:12Z

[Term]
id: GO:1902473
name: regulation of protein localization to synapse
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to synapse." [GOC:kmv, GOC:TermGenie, PMID:22588719]
synonym: "regulation of protein localisation to synapse" EXACT [GOC:TermGenie]
is_a: GO:0032880 ! regulation of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035418 ! protein localization to synapse
relationship: regulates GO:0035418 ! protein localization to synapse
created_by: kmv
creation_date: 2013-10-25T15:09:09Z

[Term]
id: GO:1902474
name: positive regulation of protein localization to synapse
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to synapse." [GOC:kmv, GOC:TermGenie, PMID:22588719]
synonym: "activation of protein localisation to synapse" NARROW [GOC:TermGenie]
synonym: "activation of protein localization to synapse" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein localisation to synapse" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation to synapse" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to synapse" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation to synapse" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to synapse" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation to synapse" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to synapse" EXACT [GOC:TermGenie]
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:1902473 ! regulation of protein localization to synapse
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035418 ! protein localization to synapse
relationship: positively_regulates GO:0035418 ! protein localization to synapse
created_by: kmv
creation_date: 2013-10-25T15:09:18Z

[Term]
id: GO:1902475
name: L-alpha-amino acid transmembrane transport
namespace: biological_process
def: "The directed movement of L-alpha-amino acid across a membrane." [GOC:kmv, GOC:TermGenie, PMID:14668347]
is_a: GO:0003333 ! amino acid transmembrane transport
is_a: GO:0015807 ! L-amino acid transport
created_by: kmv
creation_date: 2013-10-25T15:17:39Z

[Term]
id: GO:1902476
name: chloride transmembrane transport
namespace: biological_process
def: "The directed movement of chloride across a membrane." [GOC:TermGenie, GOC:vw]
is_a: GO:0006821 ! chloride transport
is_a: GO:0098661 ! inorganic anion transmembrane transport
created_by: bf
creation_date: 2013-10-28T09:44:29Z

[Term]
id: GO:1902477
name: regulation of defense response to bacterium, incompatible interaction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of defense response to bacterium, incompatible interaction." [GOC:TermGenie, PMID:24134885]
synonym: "regulation of defence response to bacterium, incompatible interaction" EXACT [GOC:TermGenie]
synonym: "regulation of defence response to pathogenic bacteria, incompatible interaction" EXACT [GOC:TermGenie]
synonym: "regulation of defence response to pathogenic bacterium, incompatible interaction" EXACT [GOC:TermGenie]
synonym: "regulation of resistance response to pathogenic bacteria" EXACT [GOC:TermGenie]
synonym: "regulation of resistance response to pathogenic bacterium" EXACT [GOC:TermGenie]
synonym: "regulation of response to pathogenic bacteria (incompatible interaction)" EXACT [GOC:TermGenie]
synonym: "regulation of response to pathogenic bacterium (incompatible interaction)" EXACT [GOC:TermGenie]
is_a: GO:0045088 ! regulation of innate immune response
is_a: GO:1900424 ! regulation of defense response to bacterium
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009816 ! defense response to bacterium, incompatible interaction
relationship: regulates GO:0009816 ! defense response to bacterium, incompatible interaction
created_by: tb
creation_date: 2013-10-30T20:13:13Z

[Term]
id: GO:1902478
name: negative regulation of defense response to bacterium, incompatible interaction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of defense response to bacterium, incompatible interaction." [GOC:TermGenie, PMID:24134885]
synonym: "down regulation of defence response to bacterium, incompatible interaction" EXACT [GOC:TermGenie]
synonym: "down regulation of defence response to pathogenic bacteria, incompatible interaction" EXACT [GOC:TermGenie]
synonym: "down regulation of defence response to pathogenic bacterium, incompatible interaction" EXACT [GOC:TermGenie]
synonym: "down regulation of defense response to bacterium, incompatible interaction" EXACT [GOC:TermGenie]
synonym: "down regulation of resistance response to pathogenic bacteria" EXACT [GOC:TermGenie]
synonym: "down regulation of resistance response to pathogenic bacterium" EXACT [GOC:TermGenie]
synonym: "down regulation of response to pathogenic bacteria (incompatible interaction)" EXACT [GOC:TermGenie]
synonym: "down regulation of response to pathogenic bacterium (incompatible interaction)" EXACT [GOC:TermGenie]
synonym: "down-regulation of defence response to bacterium, incompatible interaction" EXACT [GOC:TermGenie]
synonym: "down-regulation of defence response to pathogenic bacteria, incompatible interaction" EXACT [GOC:TermGenie]
synonym: "down-regulation of defence response to pathogenic bacterium, incompatible interaction" EXACT [GOC:TermGenie]
synonym: "down-regulation of defense response to bacterium, incompatible interaction" EXACT [GOC:TermGenie]
synonym: "down-regulation of resistance response to pathogenic bacteria" EXACT [GOC:TermGenie]
synonym: "down-regulation of resistance response to pathogenic bacterium" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to pathogenic bacteria (incompatible interaction)" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to pathogenic bacterium (incompatible interaction)" EXACT [GOC:TermGenie]
synonym: "downregulation of defence response to bacterium, incompatible interaction" EXACT [GOC:TermGenie]
synonym: "downregulation of defence response to pathogenic bacteria, incompatible interaction" EXACT [GOC:TermGenie]
synonym: "downregulation of defence response to pathogenic bacterium, incompatible interaction" EXACT [GOC:TermGenie]
synonym: "downregulation of defense response to bacterium, incompatible interaction" EXACT [GOC:TermGenie]
synonym: "downregulation of resistance response to pathogenic bacteria" EXACT [GOC:TermGenie]
synonym: "downregulation of resistance response to pathogenic bacterium" EXACT [GOC:TermGenie]
synonym: "downregulation of response to pathogenic bacteria (incompatible interaction)" EXACT [GOC:TermGenie]
synonym: "downregulation of response to pathogenic bacterium (incompatible interaction)" EXACT [GOC:TermGenie]
synonym: "inhibition of defence response to bacterium, incompatible interaction" NARROW [GOC:TermGenie]
synonym: "inhibition of defence response to pathogenic bacteria, incompatible interaction" NARROW [GOC:TermGenie]
synonym: "inhibition of defence response to pathogenic bacterium, incompatible interaction" NARROW [GOC:TermGenie]
synonym: "inhibition of defense response to bacterium, incompatible interaction" NARROW [GOC:TermGenie]
synonym: "inhibition of resistance response to pathogenic bacteria" NARROW [GOC:TermGenie]
synonym: "inhibition of resistance response to pathogenic bacterium" NARROW [GOC:TermGenie]
synonym: "inhibition of response to pathogenic bacteria (incompatible interaction)" NARROW [GOC:TermGenie]
synonym: "inhibition of response to pathogenic bacterium (incompatible interaction)" NARROW [GOC:TermGenie]
synonym: "negative regulation of defence response to bacterium, incompatible interaction" EXACT [GOC:TermGenie]
synonym: "negative regulation of defence response to pathogenic bacteria, incompatible interaction" EXACT [GOC:TermGenie]
synonym: "negative regulation of defence response to pathogenic bacterium, incompatible interaction" EXACT [GOC:TermGenie]
synonym: "negative regulation of resistance response to pathogenic bacteria" EXACT [GOC:TermGenie]
synonym: "negative regulation of resistance response to pathogenic bacterium" EXACT [GOC:TermGenie]
synonym: "negative regulation of response to pathogenic bacteria (incompatible interaction)" EXACT [GOC:TermGenie]
synonym: "negative regulation of response to pathogenic bacterium (incompatible interaction)" EXACT [GOC:TermGenie]
is_a: GO:0045824 ! negative regulation of innate immune response
is_a: GO:1900425 ! negative regulation of defense response to bacterium
is_a: GO:1902477 ! regulation of defense response to bacterium, incompatible interaction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009816 ! defense response to bacterium, incompatible interaction
relationship: negatively_regulates GO:0009816 ! defense response to bacterium, incompatible interaction
created_by: tb
creation_date: 2013-10-30T20:13:22Z

[Term]
id: GO:1902479
name: positive regulation of defense response to bacterium, incompatible interaction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of defense response to bacterium, incompatible interaction." [GOC:TermGenie, PMID:24134885]
synonym: "activation of defence response to bacterium, incompatible interaction" NARROW [GOC:TermGenie]
synonym: "activation of defence response to pathogenic bacteria, incompatible interaction" NARROW [GOC:TermGenie]
synonym: "activation of defence response to pathogenic bacterium, incompatible interaction" NARROW [GOC:TermGenie]
synonym: "activation of defense response to bacterium, incompatible interaction" NARROW [GOC:TermGenie]
synonym: "activation of resistance response to pathogenic bacteria" NARROW [GOC:TermGenie]
synonym: "activation of resistance response to pathogenic bacterium" NARROW [GOC:TermGenie]
synonym: "activation of response to pathogenic bacteria (incompatible interaction)" NARROW [GOC:TermGenie]
synonym: "activation of response to pathogenic bacterium (incompatible interaction)" NARROW [GOC:TermGenie]
synonym: "positive regulation of defence response to bacterium, incompatible interaction" EXACT [GOC:TermGenie]
synonym: "positive regulation of defence response to pathogenic bacteria, incompatible interaction" EXACT [GOC:TermGenie]
synonym: "positive regulation of defence response to pathogenic bacterium, incompatible interaction" EXACT [GOC:TermGenie]
synonym: "positive regulation of resistance response to pathogenic bacteria" EXACT [GOC:TermGenie]
synonym: "positive regulation of resistance response to pathogenic bacterium" EXACT [GOC:TermGenie]
synonym: "positive regulation of response to pathogenic bacteria (incompatible interaction)" EXACT [GOC:TermGenie]
synonym: "positive regulation of response to pathogenic bacterium (incompatible interaction)" EXACT [GOC:TermGenie]
synonym: "up regulation of defence response to bacterium, incompatible interaction" EXACT [GOC:TermGenie]
synonym: "up regulation of defence response to pathogenic bacteria, incompatible interaction" EXACT [GOC:TermGenie]
synonym: "up regulation of defence response to pathogenic bacterium, incompatible interaction" EXACT [GOC:TermGenie]
synonym: "up regulation of defense response to bacterium, incompatible interaction" EXACT [GOC:TermGenie]
synonym: "up regulation of resistance response to pathogenic bacteria" EXACT [GOC:TermGenie]
synonym: "up regulation of resistance response to pathogenic bacterium" EXACT [GOC:TermGenie]
synonym: "up regulation of response to pathogenic bacteria (incompatible interaction)" EXACT [GOC:TermGenie]
synonym: "up regulation of response to pathogenic bacterium (incompatible interaction)" EXACT [GOC:TermGenie]
synonym: "up-regulation of defence response to bacterium, incompatible interaction" EXACT [GOC:TermGenie]
synonym: "up-regulation of defence response to pathogenic bacteria, incompatible interaction" EXACT [GOC:TermGenie]
synonym: "up-regulation of defence response to pathogenic bacterium, incompatible interaction" EXACT [GOC:TermGenie]
synonym: "up-regulation of defense response to bacterium, incompatible interaction" EXACT [GOC:TermGenie]
synonym: "up-regulation of resistance response to pathogenic bacteria" EXACT [GOC:TermGenie]
synonym: "up-regulation of resistance response to pathogenic bacterium" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to pathogenic bacteria (incompatible interaction)" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to pathogenic bacterium (incompatible interaction)" EXACT [GOC:TermGenie]
synonym: "upregulation of defence response to bacterium, incompatible interaction" EXACT [GOC:TermGenie]
synonym: "upregulation of defence response to pathogenic bacteria, incompatible interaction" EXACT [GOC:TermGenie]
synonym: "upregulation of defence response to pathogenic bacterium, incompatible interaction" EXACT [GOC:TermGenie]
synonym: "upregulation of defense response to bacterium, incompatible interaction" EXACT [GOC:TermGenie]
synonym: "upregulation of resistance response to pathogenic bacteria" EXACT [GOC:TermGenie]
synonym: "upregulation of resistance response to pathogenic bacterium" EXACT [GOC:TermGenie]
synonym: "upregulation of response to pathogenic bacteria (incompatible interaction)" EXACT [GOC:TermGenie]
synonym: "upregulation of response to pathogenic bacterium (incompatible interaction)" EXACT [GOC:TermGenie]
is_a: GO:0045089 ! positive regulation of innate immune response
is_a: GO:1900426 ! positive regulation of defense response to bacterium
is_a: GO:1902477 ! regulation of defense response to bacterium, incompatible interaction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009816 ! defense response to bacterium, incompatible interaction
relationship: positively_regulates GO:0009816 ! defense response to bacterium, incompatible interaction
created_by: tb
creation_date: 2013-10-30T20:13:31Z

[Term]
id: GO:1902480
name: protein localization to mitotic spindle
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a mitotic spindle." [GOC:TermGenie, PMID:23885124]
synonym: "protein localisation in mitotic spindle" EXACT [GOC:TermGenie]
synonym: "protein localisation to mitotic spindle" EXACT [GOC:TermGenie]
synonym: "protein localization in mitotic spindle" EXACT [GOC:TermGenie]
is_a: GO:0072698 ! protein localization to microtubule cytoskeleton
created_by: mah
creation_date: 2013-11-04T13:16:47Z

[Term]
id: GO:1902481
name: gamma-tubulin complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a gamma-tubulin complex." [GOC:TermGenie, PMID:23885124]
synonym: "gamma-tubulin complex formation" EXACT [GOC:TermGenie]
is_a: GO:0006461 ! protein complex assembly
created_by: mah
creation_date: 2013-11-04T13:21:12Z

[Term]
id: GO:1902482
name: regulatory T cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a regulatory T cell." [GOC:nhn, GOC:TermGenie, PUBMED:20471291]
synonym: "regulatory T cell apoptosis" NARROW [GOC:TermGenie]
synonym: "regulatory T lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "regulatory T lymphocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "regulatory T-cell apoptosis" NARROW [GOC:TermGenie]
synonym: "regulatory T-cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "regulatory T-lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "regulatory T-lymphocyte apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0070231 ! T cell apoptotic process
created_by: Nevila.Nouspikel
creation_date: 2013-11-04T17:18:09Z

[Term]
id: GO:1902483
name: cytotoxic T cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a cytotoxic T cell." [GOC:nhn, GOC:TermGenie, PUBMED:19604492]
synonym: "cytotoxic T cell apoptosis" NARROW [GOC:TermGenie]
synonym: "cytotoxic T lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "cytotoxic T lymphocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "cytotoxic T-cell apoptosis" NARROW [GOC:TermGenie]
synonym: "cytotoxic T-cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "cytotoxic T-lymphocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "cytotoxic T-lymphocyte apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0070231 ! T cell apoptotic process
created_by: Nevila.Nouspikel
creation_date: 2013-11-04T17:23:48Z

[Term]
id: GO:1902484
name: Sertoli cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a Sertoli cell." [GOC:ic, GOC:TermGenie, PMID:17761895]
synonym: "Sertoli cell apoptosis" NARROW [GOC:TermGenie]
is_a: GO:1904019 ! epithelial cell apoptotic process
created_by: pr
creation_date: 2013-11-06T11:27:34Z

[Term]
id: GO:1902485
name: L-cysteine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with L-cysteine." [GOC:bhm, GOC:TermGenie, PMID:12941942]
is_a: GO:0016597 ! amino acid binding
is_a: GO:0043169 ! cation binding
is_a: GO:1901681 ! sulfur compound binding
created_by: bhm
creation_date: 2013-11-12T09:06:28Z

[Term]
id: GO:1902486
name: protein localization to growing cell tip
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a growing cell tip." [GOC:TermGenie, PMID:23041194]
synonym: "protein localisation in growing cell tip" EXACT [GOC:TermGenie]
synonym: "protein localisation to growing cell tip" EXACT [GOC:TermGenie]
synonym: "protein localization in growing cell tip" EXACT [GOC:TermGenie]
is_a: GO:1990151 ! protein localization to cell tip
created_by: mah
creation_date: 2013-11-12T16:38:13Z

[Term]
id: GO:1902487
name: protein localization to non-growing cell tip
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a non-growing cell tip." [GOC:TermGenie, PMID:21652630, PMID:23041194]
synonym: "protein localisation in non-growing cell tip" EXACT [GOC:TermGenie]
synonym: "protein localisation to non-growing cell tip" EXACT [GOC:TermGenie]
synonym: "protein localization in non-growing cell tip" EXACT [GOC:TermGenie]
is_a: GO:1990151 ! protein localization to cell tip
created_by: mah
creation_date: 2013-11-12T16:38:22Z

[Term]
id: GO:1902488
name: cholangiocyte apoptotic process
namespace: biological_process
def: "Any apoptotic process in a cholangiocyte." [GOC:TermGenie, PMID:22961800]
synonym: "cholangiocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie]
synonym: "epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:1904019 ! epithelial cell apoptotic process
created_by: cynthia.smith
creation_date: 2013-11-12T15:30:08Z

[Term]
id: GO:1902489
name: hepatoblast apoptotic process
namespace: biological_process
def: "Any apoptotic process in a hepatoblast." [GOC:TermGenie, PMID:22412967]
synonym: "hepatoblast apoptosis" NARROW [GOC:TermGenie]
is_a: GO:0006915 ! apoptotic process
created_by: cynthia.smith
creation_date: 2013-11-12T17:02:52Z

[Term]
id: GO:1902490
name: regulation of sperm capacitation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sperm capacitation." [GOC:hjd, GOC:TermGenie, PMID:22539676]
synonym: "regulation of sperm activation" RELATED [GOC:TermGenie]
is_a: GO:0030856 ! regulation of epithelial cell differentiation
is_a: GO:0043900 ! regulation of multi-organism process
is_a: GO:1903429 ! regulation of cell maturation
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048240 ! sperm capacitation
relationship: regulates GO:0048240 ! sperm capacitation
created_by: hjd
creation_date: 2013-11-12T21:17:03Z

[Term]
id: GO:1902491
name: negative regulation of sperm capacitation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sperm capacitation." [GOC:hjd, GOC:TermGenie, PMID:22539676]
synonym: "down regulation of sperm activation" RELATED [GOC:TermGenie]
synonym: "down regulation of sperm capacitation" EXACT [GOC:TermGenie]
synonym: "down-regulation of sperm activation" RELATED [GOC:TermGenie]
synonym: "down-regulation of sperm capacitation" EXACT [GOC:TermGenie]
synonym: "downregulation of sperm activation" RELATED [GOC:TermGenie]
synonym: "downregulation of sperm capacitation" EXACT [GOC:TermGenie]
synonym: "inhibition of sperm activation" RELATED [GOC:TermGenie]
synonym: "inhibition of sperm capacitation" NARROW [GOC:TermGenie]
synonym: "negative regulation of sperm activation" RELATED [GOC:TermGenie]
is_a: GO:0043901 ! negative regulation of multi-organism process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1902490 ! regulation of sperm capacitation
is_a: GO:1903430 ! negative regulation of cell maturation
is_a: GO:2000242 ! negative regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048240 ! sperm capacitation
relationship: negatively_regulates GO:0048240 ! sperm capacitation
created_by: hjd
creation_date: 2013-11-12T21:17:12Z

[Term]
id: GO:1902492
name: positive regulation of sperm capacitation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sperm capacitation." [GOC:hjd, GOC:TermGenie, PMID:22539676]
synonym: "activation of sperm activation" RELATED [GOC:TermGenie]
synonym: "activation of sperm capacitation" NARROW [GOC:TermGenie]
synonym: "positive regulation of sperm activation" RELATED [GOC:TermGenie]
synonym: "up regulation of sperm activation" RELATED [GOC:TermGenie]
synonym: "up regulation of sperm capacitation" EXACT [GOC:TermGenie]
synonym: "up-regulation of sperm activation" RELATED [GOC:TermGenie]
synonym: "up-regulation of sperm capacitation" EXACT [GOC:TermGenie]
synonym: "upregulation of sperm activation" RELATED [GOC:TermGenie]
synonym: "upregulation of sperm capacitation" EXACT [GOC:TermGenie]
is_a: GO:0043902 ! positive regulation of multi-organism process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1902490 ! regulation of sperm capacitation
is_a: GO:1903431 ! positive regulation of cell maturation
is_a: GO:2000243 ! positive regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048240 ! sperm capacitation
relationship: positively_regulates GO:0048240 ! sperm capacitation
created_by: hjd
creation_date: 2013-11-12T21:17:21Z

[Term]
id: GO:1902493
name: acetyltransferase complex
namespace: cellular_component
def: "A protein complex which is capable of acetyltransferase activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]
is_a: GO:1990234 ! transferase complex
created_by: bhm
creation_date: 2013-11-13T16:16:45Z

[Term]
id: GO:1902494
name: catalytic complex
namespace: cellular_component
def: "A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]
synonym: "enzyme complex" EXACT [GOC:bhm, GOC:jl]
is_a: GO:0043234 ! protein complex
created_by: bhm
creation_date: 2013-11-13T16:18:47Z

[Term]
id: GO:1902495
name: transmembrane transporter complex
namespace: cellular_component
def: "A transmembrane protein complex which enables the transfer of a substance from one side of a membrane to the other." [GOC:bhm, GOC:TermGenie, PMID:18024586]
is_a: GO:0098796 ! membrane protein complex
is_a: GO:1990351 ! transporter complex
relationship: part_of GO:0016021 ! integral component of membrane
created_by: bhm
creation_date: 2013-11-13T16:23:04Z

[Term]
id: GO:1902496
name: protein binding involved in negative regulation of telomere maintenance via telomerase
namespace: molecular_function
def: "Any protein binding that is involved in negative regulation of telomere maintenance via telomerase." [GOC:dph, GOC:TermGenie, GOC:vw, PMID:24013504]
synonym: "protein binding involved in down regulation of telomere maintenance via telomerase activity" EXACT [GOC:TermGenie]
synonym: "protein binding involved in down-regulation of telomere maintenance via telomerase activity" EXACT [GOC:TermGenie]
synonym: "protein binding involved in downregulation of telomere maintenance via telomerase activity" EXACT [GOC:TermGenie]
synonym: "protein binding involved in inhibition of telomere maintenance via telomerase" NARROW [GOC:TermGenie]
is_a: GO:0005515 ! protein binding
intersection_of: GO:0005515 ! protein binding
intersection_of: part_of GO:0032211 ! negative regulation of telomere maintenance via telomerase
relationship: part_of GO:0032211 ! negative regulation of telomere maintenance via telomerase
created_by: dph
creation_date: 2013-11-13T16:22:49Z

[Term]
id: GO:1902497
name: iron-sulfur cluster transport
namespace: biological_process
def: "The directed movement of an iron-sulfur cluster into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:TermGenie, PMID:19810706]
is_a: GO:1901678 ! iron coordination entity transport
created_by: dph
creation_date: 2013-11-13T16:33:00Z

[Term]
id: GO:1902498
name: regulation of protein autoubiquitination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein autoubiquitination." [GOC:rb, GOC:TermGenie, PMID:24069405]
synonym: "regulation of protein auto-ubiquitination" EXACT [GOC:TermGenie]
synonym: "regulation of protein auto-ubiquitinylation" EXACT [GOC:TermGenie]
synonym: "regulation of protein autoubiquitinylation" EXACT [GOC:TermGenie]
synonym: "regulation of protein self-ubiquitination" EXACT [GOC:TermGenie]
synonym: "regulation of protein self-ubiquitinylation" EXACT [GOC:TermGenie]
is_a: GO:0031396 ! regulation of protein ubiquitination
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051865 ! protein autoubiquitination
relationship: regulates GO:0051865 ! protein autoubiquitination
created_by: rb
creation_date: 2013-11-13T21:03:28Z

[Term]
id: GO:1902499
name: positive regulation of protein autoubiquitination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein autoubiquitination." [GOC:rb, GOC:TermGenie, PMID:24069405]
synonym: "activation of protein auto-ubiquitination" NARROW [GOC:TermGenie]
synonym: "activation of protein auto-ubiquitinylation" NARROW [GOC:TermGenie]
synonym: "activation of protein autoubiquitination" NARROW [GOC:TermGenie]
synonym: "activation of protein autoubiquitinylation" NARROW [GOC:TermGenie]
synonym: "activation of protein self-ubiquitination" NARROW [GOC:TermGenie]
synonym: "activation of protein self-ubiquitinylation" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein auto-ubiquitination" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein auto-ubiquitinylation" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein autoubiquitinylation" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein self-ubiquitination" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein self-ubiquitinylation" EXACT [GOC:TermGenie]
synonym: "up regulation of protein auto-ubiquitination" EXACT [GOC:TermGenie]
synonym: "up regulation of protein auto-ubiquitinylation" EXACT [GOC:TermGenie]
synonym: "up regulation of protein autoubiquitination" EXACT [GOC:TermGenie]
synonym: "up regulation of protein autoubiquitinylation" EXACT [GOC:TermGenie]
synonym: "up regulation of protein self-ubiquitination" EXACT [GOC:TermGenie]
synonym: "up regulation of protein self-ubiquitinylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein auto-ubiquitination" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein auto-ubiquitinylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein autoubiquitination" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein autoubiquitinylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein self-ubiquitination" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein self-ubiquitinylation" EXACT [GOC:TermGenie]
synonym: "upregulation of protein auto-ubiquitination" EXACT [GOC:TermGenie]
synonym: "upregulation of protein auto-ubiquitinylation" EXACT [GOC:TermGenie]
synonym: "upregulation of protein autoubiquitination" EXACT [GOC:TermGenie]
synonym: "upregulation of protein autoubiquitinylation" EXACT [GOC:TermGenie]
synonym: "upregulation of protein self-ubiquitination" EXACT [GOC:TermGenie]
synonym: "upregulation of protein self-ubiquitinylation" EXACT [GOC:TermGenie]
is_a: GO:0031398 ! positive regulation of protein ubiquitination
is_a: GO:1902498 ! regulation of protein autoubiquitination
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051865 ! protein autoubiquitination
relationship: positively_regulates GO:0051865 ! protein autoubiquitination
created_by: rb
creation_date: 2013-11-13T21:03:37Z

[Term]
id: GO:1902500
name: vacuolar HOPS complex
namespace: cellular_component
def: "Any HOPS complex that is part of a vacuolar membrane." [GOC:TermGenie, PMID:23645161]
synonym: "vacuolar membrane HOPS complex" EXACT []
is_a: GO:0030897 ! HOPS complex
is_a: GO:0044437 ! vacuolar part
intersection_of: GO:0030897 ! HOPS complex
intersection_of: part_of GO:0005774 ! vacuolar membrane
relationship: part_of GO:0005774 ! vacuolar membrane
created_by: tb
creation_date: 2013-11-14T00:09:50Z

[Term]
id: GO:1902501
name: lysosomal HOPS complex
namespace: cellular_component
def: "Any HOPS complex that is part of a lysosomal membrane." [GOC:TermGenie, PMID:23645161]
synonym: "lysosomal membrane HOPS complex" EXACT []
is_a: GO:1902500 ! vacuolar HOPS complex
intersection_of: GO:0030897 ! HOPS complex
intersection_of: part_of GO:0005765 ! lysosomal membrane
relationship: part_of GO:0005765 ! lysosomal membrane
created_by: tb
creation_date: 2013-11-14T00:09:59Z

[Term]
id: GO:1902502
name: multivesicular body HOPS complex
namespace: cellular_component
def: "Any HOPS complex that is part of a multivesicular body membrane." [GOC:TermGenie, PMID:23645161]
synonym: "multivesicular body membrane HOPS complex" EXACT []
is_a: GO:0044440 ! endosomal part
is_a: GO:1902500 ! vacuolar HOPS complex
intersection_of: GO:0030897 ! HOPS complex
intersection_of: part_of GO:0032585 ! multivesicular body membrane
relationship: part_of GO:0032585 ! multivesicular body membrane
created_by: tb
creation_date: 2013-11-14T00:10:08Z

[Term]
id: GO:1902503
name: adenylyltransferase complex
namespace: cellular_component
def: "A protein complex which is capable of adenylyltransferase activity." [GOC:bhm, GOC:TermGenie, PMID:11713534]
synonym: "ThiF-ThiS complex" RELATED [GOC:dph]
is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups
created_by: bhm
creation_date: 2013-11-14T10:37:25Z

[Term]
id: GO:1902504
name: regulation of signal transduction involved in mitotic G2 DNA damage checkpoint
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of signal transduction involved in mitotic G2 DNA damage checkpoint." [GOC:TermGenie, PMID:16299494]
synonym: "regulation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint" EXACT [GOC:TermGenie]
is_a: GO:0010389 ! regulation of G2/M transition of mitotic cell cycle
is_a: GO:1902531 ! regulation of intracellular signal transduction
is_a: GO:1904289 ! regulation of mitotic DNA damage checkpoint
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072434 ! signal transduction involved in mitotic G2 DNA damage checkpoint
relationship: regulates GO:0072434 ! signal transduction involved in mitotic G2 DNA damage checkpoint
created_by: vw
creation_date: 2013-11-14T15:26:46Z

[Term]
id: GO:1902505
name: negative regulation of signal transduction involved in mitotic G2 DNA damage checkpoint
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction involved in mitotic G2 DNA damage checkpoint." [GOC:TermGenie, PMID:16299494]
synonym: "down regulation of signal transduction involved in mitotic G2 DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "down regulation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "down-regulation of signal transduction involved in mitotic G2 DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "down-regulation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "downregulation of signal transduction involved in mitotic G2 DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "downregulation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "inhibition of signal transduction involved in mitotic G2 DNA damage checkpoint" NARROW [GOC:TermGenie]
synonym: "inhibition of signal transduction involved in mitotic G2/M transition DNA damage checkpoint" NARROW [GOC:TermGenie]
synonym: "negative regulation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint" EXACT [GOC:TermGenie]
is_a: GO:0010971 ! positive regulation of G2/M transition of mitotic cell cycle
is_a: GO:1902504 ! regulation of signal transduction involved in mitotic G2 DNA damage checkpoint
is_a: GO:1902532 ! negative regulation of intracellular signal transduction
is_a: GO:1904290 ! negative regulation of mitotic DNA damage checkpoint
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072434 ! signal transduction involved in mitotic G2 DNA damage checkpoint
relationship: negatively_regulates GO:0072434 ! signal transduction involved in mitotic G2 DNA damage checkpoint
created_by: vw
creation_date: 2013-11-14T15:26:55Z

[Term]
id: GO:1902506
name: positive regulation of signal transduction involved in mitotic G2 DNA damage checkpoint
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of signal transduction involved in mitotic G2 DNA damage checkpoint." [GOC:TermGenie, PMID:16299494]
synonym: "activation of signal transduction involved in mitotic G2 DNA damage checkpoint" NARROW [GOC:TermGenie]
synonym: "activation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint" NARROW [GOC:TermGenie]
synonym: "positive regulation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "up regulation of signal transduction involved in mitotic G2 DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "up regulation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "up-regulation of signal transduction involved in mitotic G2 DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "up-regulation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "upregulation of signal transduction involved in mitotic G2 DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "upregulation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint" EXACT [GOC:TermGenie]
is_a: GO:1902504 ! regulation of signal transduction involved in mitotic G2 DNA damage checkpoint
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
is_a: GO:1904291 ! positive regulation of mitotic DNA damage checkpoint
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072434 ! signal transduction involved in mitotic G2 DNA damage checkpoint
relationship: positively_regulates GO:0072434 ! signal transduction involved in mitotic G2 DNA damage checkpoint
created_by: vw
creation_date: 2013-11-14T15:27:04Z

[Term]
id: GO:1902507
name: thiazole synthase complex
namespace: cellular_component
def: "A protein complex which is capable of thiazole synthase activity." [GOC:bhm, GOC:TermGenie, PMID:12650933]
is_a: GO:1990228 ! sulfurtransferase complex
created_by: bhm
creation_date: 2013-11-14T16:19:28Z

[Term]
id: GO:1902508
name: 2-iminoacetate synthase complex
namespace: cellular_component
def: "A protein complex which is capable of 2-iminoacetate synthase activity." [GOC:bhm, GOC:TermGenie, PMID:12650933]
synonym: "ThiH-ThiG complex" NARROW [GOC:bhm, GOC:dph]
is_a: GO:1902494 ! catalytic complex
created_by: bhm
creation_date: 2013-11-14T16:56:44Z

[Term]
id: GO:1902509
name: methionine-importing complex
namespace: cellular_component
def: "A protein complex which is capable of methionine-importing activity." [GOC:pr, GOC:TermGenie, PMID:23748165]
synonym: "methionine importer complex" EXACT []
synonym: "methionine importing complex" EXACT []
is_a: GO:1902495 ! transmembrane transporter complex
created_by: pr
creation_date: 2013-11-15T10:42:41Z

[Term]
id: GO:1902510
name: regulation of apoptotic DNA fragmentation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of apoptotic DNA fragmentation." [GOC:hjd, GOC:TermGenie, PMID:15572351, PMID:15723341]
comment: DNA fragmentation in response to apoptotic signals is achieved through the activity of apoptotic nucleases (see GO:0006309 'apoptotic DNA fragmentation'). Gene products involved in compartmentalization of such nucleases and in activation or repression of their enzymatic activity should be annotated to the regulation term GO:1902510 'regulation of apoptotic DNA fragmentation' or to one of its children (see PMID:15723341).
synonym: "regulation of chromatinolysis" BROAD [GOC:TermGenie]
synonym: "regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie]
synonym: "regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie]
synonym: "regulation of DNA fragmentation" BROAD [GOC:TermGenie]
synonym: "regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie]
synonym: "regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie]
is_a: GO:0051128 ! regulation of cellular component organization
is_a: GO:1900117 ! regulation of execution phase of apoptosis
is_a: GO:1903624 ! regulation of DNA catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006309 ! apoptotic DNA fragmentation
relationship: regulates GO:0006309 ! apoptotic DNA fragmentation
created_by: hjd
creation_date: 2013-11-15T18:28:32Z

[Term]
id: GO:1902511
name: negative regulation of apoptotic DNA fragmentation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic DNA fragmentation." [GOC:hjd, GOC:TermGenie, PMID:15572351]
synonym: "down regulation of apoptotic DNA fragmentation" EXACT [GOC:TermGenie]
synonym: "down regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie]
synonym: "down regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie]
synonym: "down regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie]
synonym: "down regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptotic DNA fragmentation" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie]
synonym: "down-regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptotic DNA fragmentation" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie]
synonym: "downregulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie]
synonym: "inhibition of apoptotic DNA fragmentation" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA catabolic process during apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA catabolism during apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA fragmentation involved in apoptotic nuclear change" NARROW [GOC:TermGenie]
synonym: "inhibition of endonucleolytic DNA catabolic process involved in apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie]
synonym: "negative regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie]
synonym: "negative regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie]
synonym: "negative regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1900118 ! negative regulation of execution phase of apoptosis
is_a: GO:1902510 ! regulation of apoptotic DNA fragmentation
is_a: GO:1903625 ! negative regulation of DNA catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006309 ! apoptotic DNA fragmentation
relationship: negatively_regulates GO:0006309 ! apoptotic DNA fragmentation
created_by: hjd
creation_date: 2013-11-15T18:28:41Z

[Term]
id: GO:1902512
name: positive regulation of apoptotic DNA fragmentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of apoptotic DNA fragmentation." [GOC:hjd, GOC:TermGenie, PMID:15572351]
synonym: "activation of apoptotic DNA fragmentation" NARROW [GOC:TermGenie]
synonym: "activation of DNA catabolic process during apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of DNA catabolism during apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of DNA fragmentation involved in apoptotic nuclear change" NARROW [GOC:TermGenie]
synonym: "activation of endonucleolytic DNA catabolic process involved in apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie]
synonym: "positive regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie]
synonym: "positive regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie]
synonym: "positive regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptotic DNA fragmentation" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie]
synonym: "up regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptotic DNA fragmentation" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie]
synonym: "up-regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptotic DNA fragmentation" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie]
synonym: "upregulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1900119 ! positive regulation of execution phase of apoptosis
is_a: GO:1902510 ! regulation of apoptotic DNA fragmentation
is_a: GO:1903626 ! positive regulation of DNA catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006309 ! apoptotic DNA fragmentation
relationship: positively_regulates GO:0006309 ! apoptotic DNA fragmentation
created_by: hjd
creation_date: 2013-11-15T18:28:50Z

[Term]
id: GO:1902513
name: regulation of organelle transport along microtubule
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of organelle transport along microtubule." [GOC:dph, GOC:TermGenie, PMID:21147087]
synonym: "regulation of microtubule-based organelle localization" EXACT [GOC:TermGenie]
is_a: GO:0032386 ! regulation of intracellular transport
is_a: GO:0060632 ! regulation of microtubule-based movement
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072384 ! organelle transport along microtubule
relationship: regulates GO:0072384 ! organelle transport along microtubule
created_by: dph
creation_date: 2013-11-15T20:15:17Z

[Term]
id: GO:1902514
name: regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of generation of calcium ion transmembrane transport via high voltage-gated calcium channel." [GOC:dph, GOC:pg, GOC:TermGenie, PMID:1611048]
synonym: "regulation of generation of L-type calcium current" RELATED []
is_a: GO:1903169 ! regulation of calcium ion transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061577 ! calcium ion transmembrane transport via high voltage-gated calcium channel
relationship: regulates GO:0061577 ! calcium ion transmembrane transport via high voltage-gated calcium channel
created_by: dph
creation_date: 2013-11-16T00:04:42Z

[Term]
id: GO:1902515
name: thioredoxin-disulfide reductase complex
namespace: cellular_component
def: "A protein complex which is capable of thioredoxin-disulfide reductase activity." [GOC:bhm, GOC:TermGenie, PMID:10947986]
comment: An example of this is thioredoxin reductase (TrxB) in E. coli [P0A9P4] in PMID:10947986.
is_a: GO:1990204 ! oxidoreductase complex
created_by: bhm
creation_date: 2013-11-26T11:43:38Z

[Term]
id: GO:1902516
name: sn-glycerol 3-phosphate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with sn-glycerol 3-phosphate." [GOC:bhm, GOC:TermGenie, PMID:23013274]
comment: An example of this is UgpB in E. coli [P0AG80] - see PMID:23013274.
is_a: GO:0043168 ! anion binding
is_a: GO:0097367 ! carbohydrate derivative binding
created_by: bhm
creation_date: 2013-11-27T16:50:55Z

[Term]
id: GO:1902517
name: glycerol-3-phosphate-transporting ATPase complex
namespace: cellular_component
def: "A protein complex which is capable of glycerol-3-phosphate-transporting ATPase activity." [GOC:bhm, GOC:TermGenie, PMID:23013274]
comment: An example of this is UgpB in E. coli in PMID:23013274.
is_a: GO:0043190 ! ATP-binding cassette (ABC) transporter complex
created_by: bhm
creation_date: 2013-11-27T16:53:33Z

[Term]
id: GO:1902518
name: response to cyclophosphamide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclophosphamide stimulus." [GOC:dw, GOC:TermGenie, PMID:23648065]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
is_a: GO:0010243 ! response to organonitrogen compound
created_by: dw
creation_date: 2013-12-02T09:34:08Z

[Term]
id: GO:1902519
name: response to docetaxel trihydrate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a docetaxel trihydrate stimulus." [GOC:dw, GOC:TermGenie, PMID:23648065]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
synonym: "response to docetaxel" RELATED []
is_a: GO:0042221 ! response to chemical
created_by: dw
creation_date: 2013-12-02T09:44:04Z

[Term]
id: GO:1902520
name: response to doxorubicin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a doxorubicin stimulus." [GOC:dw, GOC:TermGenie, PMID:23648065]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
is_a: GO:1901654 ! response to ketone
is_a: GO:1903416 ! response to glycoside
created_by: dw
creation_date: 2013-12-02T09:44:13Z

[Term]
id: GO:1902521
name: response to etoposide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an etoposide stimulus." [GOC:dw, GOC:TermGenie, PMID:23648065]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1904631 ! response to glucoside
created_by: dw
creation_date: 2013-12-02T09:44:22Z

[Term]
id: GO:1902522
name: response to 4'-epidoxorubicin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 4'-epidoxorubicin stimulus." [GOC:dw, GOC:TermGenie, PMID:23648065]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
synonym: "response to epirubicin" RELATED []
is_a: GO:1901654 ! response to ketone
is_a: GO:1903416 ! response to glycoside
created_by: dw
creation_date: 2013-12-02T09:44:31Z

[Term]
id: GO:1902523
name: positive regulation of protein K63-linked ubiquitination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein K63-linked ubiquitination." [GOC:TermGenie, PMID:21931591]
comment: An example is BIRC2 (UniProt ID Q13490) in PMID:21931591.
synonym: "activation of protein K63-linked polyubiquitination" NARROW [GOC:TermGenie]
synonym: "activation of protein K63-linked ubiquitination" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein K63-linked polyubiquitination" EXACT [GOC:TermGenie]
synonym: "up regulation of protein K63-linked polyubiquitination" EXACT [GOC:TermGenie]
synonym: "up regulation of protein K63-linked ubiquitination" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein K63-linked polyubiquitination" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein K63-linked ubiquitination" EXACT [GOC:TermGenie]
synonym: "upregulation of protein K63-linked polyubiquitination" EXACT [GOC:TermGenie]
synonym: "upregulation of protein K63-linked ubiquitination" EXACT [GOC:TermGenie]
is_a: GO:1900044 ! regulation of protein K63-linked ubiquitination
is_a: GO:1902916 ! positive regulation of protein polyubiquitination
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070534 ! protein K63-linked ubiquitination
relationship: positively_regulates GO:0070534 ! protein K63-linked ubiquitination
created_by: ppm
creation_date: 2013-12-02T09:52:05Z

[Term]
id: GO:1902524
name: positive regulation of protein K48-linked ubiquitination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein K48-linked ubiquitination." [GOC:TermGenie, PMID:21931591]
comment: An example is BIRC2 (UniProt ID Q13490) in PMID:21931591.
synonym: "activation of protein K48-linked polyubiquitination" NARROW [GOC:TermGenie]
synonym: "activation of protein K48-linked ubiquitination" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein K48-linked polyubiquitination" EXACT [GOC:TermGenie]
synonym: "up regulation of protein K48-linked polyubiquitination" EXACT [GOC:TermGenie]
synonym: "up regulation of protein K48-linked ubiquitination" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein K48-linked polyubiquitination" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein K48-linked ubiquitination" EXACT [GOC:TermGenie]
synonym: "upregulation of protein K48-linked polyubiquitination" EXACT [GOC:TermGenie]
synonym: "upregulation of protein K48-linked ubiquitination" EXACT [GOC:TermGenie]
is_a: GO:1902916 ! positive regulation of protein polyubiquitination
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070936 ! protein K48-linked ubiquitination
relationship: positively_regulates GO:0070936 ! protein K48-linked ubiquitination
created_by: ppm
creation_date: 2013-12-02T09:56:40Z

[Term]
id: GO:1902525
name: regulation of protein monoubiquitination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein monoubiquitination." [GOC:TermGenie, PMID:21931591]
synonym: "regulation of protein monoubiquitinylation" EXACT [GOC:TermGenie]
synonym: "regulation of protein monoubiquitylation" EXACT [GOC:TermGenie]
is_a: GO:0031396 ! regulation of protein ubiquitination
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006513 ! protein monoubiquitination
relationship: regulates GO:0006513 ! protein monoubiquitination
created_by: ppm
creation_date: 2013-12-02T09:58:56Z

[Term]
id: GO:1902526
name: negative regulation of protein monoubiquitination
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein monoubiquitination." [GOC:TermGenie, PMID:21931591]
synonym: "down regulation of protein monoubiquitination" EXACT [GOC:TermGenie]
synonym: "down regulation of protein monoubiquitinylation" EXACT [GOC:TermGenie]
synonym: "down regulation of protein monoubiquitylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein monoubiquitination" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein monoubiquitinylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein monoubiquitylation" EXACT [GOC:TermGenie]
synonym: "downregulation of protein monoubiquitination" EXACT [GOC:TermGenie]
synonym: "downregulation of protein monoubiquitinylation" EXACT [GOC:TermGenie]
synonym: "downregulation of protein monoubiquitylation" EXACT [GOC:TermGenie]
synonym: "inhibition of protein monoubiquitination" NARROW [GOC:TermGenie]
synonym: "inhibition of protein monoubiquitinylation" NARROW [GOC:TermGenie]
synonym: "inhibition of protein monoubiquitylation" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein monoubiquitinylation" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein monoubiquitylation" EXACT [GOC:TermGenie]
is_a: GO:0031397 ! negative regulation of protein ubiquitination
is_a: GO:1902525 ! regulation of protein monoubiquitination
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006513 ! protein monoubiquitination
relationship: negatively_regulates GO:0006513 ! protein monoubiquitination
created_by: ppm
creation_date: 2013-12-02T09:59:05Z

[Term]
id: GO:1902527
name: positive regulation of protein monoubiquitination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein monoubiquitination." [GOC:TermGenie, PMID:21931591]
comment: An example is BIRC2 (UniProt ID Q13490) in PMID:21931591.
synonym: "activation of protein monoubiquitination" NARROW [GOC:TermGenie]
synonym: "activation of protein monoubiquitinylation" NARROW [GOC:TermGenie]
synonym: "activation of protein monoubiquitylation" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein monoubiquitinylation" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein monoubiquitylation" EXACT [GOC:TermGenie]
synonym: "up regulation of protein monoubiquitination" EXACT [GOC:TermGenie]
synonym: "up regulation of protein monoubiquitinylation" EXACT [GOC:TermGenie]
synonym: "up regulation of protein monoubiquitylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein monoubiquitination" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein monoubiquitinylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein monoubiquitylation" EXACT [GOC:TermGenie]
synonym: "upregulation of protein monoubiquitination" EXACT [GOC:TermGenie]
synonym: "upregulation of protein monoubiquitinylation" EXACT [GOC:TermGenie]
synonym: "upregulation of protein monoubiquitylation" EXACT [GOC:TermGenie]
is_a: GO:0031398 ! positive regulation of protein ubiquitination
is_a: GO:1902525 ! regulation of protein monoubiquitination
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006513 ! protein monoubiquitination
relationship: positively_regulates GO:0006513 ! protein monoubiquitination
created_by: ppm
creation_date: 2013-12-02T09:59:21Z

[Term]
id: GO:1902528
name: regulation of protein linear polyubiquitination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein linear polyubiquitination." [GOC:TermGenie, PMID:21931591]
synonym: "regulation of M1 linkage" NARROW [GOC:TermGenie]
is_a: GO:1902914 ! regulation of protein polyubiquitination
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097039 ! protein linear polyubiquitination
relationship: regulates GO:0097039 ! protein linear polyubiquitination
created_by: ppm
creation_date: 2013-12-02T10:03:00Z

[Term]
id: GO:1902529
name: negative regulation of protein linear polyubiquitination
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein linear polyubiquitination." [GOC:TermGenie, PMID:21931591]
synonym: "down regulation of M1 linkage" NARROW [GOC:TermGenie]
synonym: "down regulation of protein linear polyubiquitination" EXACT [GOC:TermGenie]
synonym: "down-regulation of M1 linkage" NARROW [GOC:TermGenie]
synonym: "down-regulation of protein linear polyubiquitination" EXACT [GOC:TermGenie]
synonym: "downregulation of M1 linkage" NARROW [GOC:TermGenie]
synonym: "downregulation of protein linear polyubiquitination" EXACT [GOC:TermGenie]
synonym: "inhibition of M1 linkage" NARROW [GOC:TermGenie]
synonym: "inhibition of protein linear polyubiquitination" NARROW [GOC:TermGenie]
synonym: "negative regulation of M1 linkage" NARROW [GOC:TermGenie]
is_a: GO:1902528 ! regulation of protein linear polyubiquitination
is_a: GO:1902915 ! negative regulation of protein polyubiquitination
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097039 ! protein linear polyubiquitination
relationship: negatively_regulates GO:0097039 ! protein linear polyubiquitination
created_by: ppm
creation_date: 2013-12-02T10:03:09Z

[Term]
id: GO:1902530
name: positive regulation of protein linear polyubiquitination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein linear polyubiquitination." [GOC:TermGenie, PMID:21931591]
comment: An example is BIRC2 (UniProt ID Q13490) in PMID:21931591.
synonym: "activation of M1 linkage" NARROW [GOC:TermGenie]
synonym: "activation of protein linear polyubiquitination" NARROW [GOC:TermGenie]
synonym: "positive regulation of M1 linkage" NARROW [GOC:TermGenie]
synonym: "up regulation of M1 linkage" NARROW [GOC:TermGenie]
synonym: "up regulation of protein linear polyubiquitination" EXACT [GOC:TermGenie]
synonym: "up-regulation of M1 linkage" NARROW [GOC:TermGenie]
synonym: "up-regulation of protein linear polyubiquitination" EXACT [GOC:TermGenie]
synonym: "upregulation of M1 linkage" NARROW [GOC:TermGenie]
synonym: "upregulation of protein linear polyubiquitination" EXACT [GOC:TermGenie]
is_a: GO:1902528 ! regulation of protein linear polyubiquitination
is_a: GO:1902916 ! positive regulation of protein polyubiquitination
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097039 ! protein linear polyubiquitination
relationship: positively_regulates GO:0097039 ! protein linear polyubiquitination
created_by: ppm
creation_date: 2013-12-02T10:03:18Z

[Term]
id: GO:1902531
name: regulation of intracellular signal transduction
namespace: biological_process
alt_id: GO:0010627
def: "Any process that modulates the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]
synonym: "regulation of intracellular protein kinase cascade" NARROW []
synonym: "regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "regulation of intracellular signaling cascade" EXACT [GOC:TermGenie]
synonym: "regulation of intracellular signaling chain" EXACT [GOC:TermGenie]
synonym: "regulation of intracellular signaling pathway" RELATED [GOC:TermGenie]
synonym: "regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie]
is_a: GO:0009966 ! regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035556 ! intracellular signal transduction
relationship: regulates GO:0035556 ! intracellular signal transduction
created_by: bf
creation_date: 2013-12-02T11:32:52Z

[Term]
id: GO:1902532
name: negative regulation of intracellular signal transduction
namespace: biological_process
alt_id: GO:0010741
def: "Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]
synonym: "down regulation of intracellular signal transduction" EXACT [GOC:TermGenie]
synonym: "down regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "down regulation of intracellular signaling cascade" NARROW [GOC:TermGenie]
synonym: "down regulation of intracellular signaling chain" EXACT [GOC:TermGenie]
synonym: "down regulation of intracellular signaling pathway" RELATED [GOC:TermGenie]
synonym: "down regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "down regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie]
synonym: "down-regulation of intracellular signal transduction" EXACT [GOC:TermGenie]
synonym: "down-regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "down-regulation of intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "down-regulation of intracellular signaling chain" EXACT [GOC:TermGenie]
synonym: "down-regulation of intracellular signaling pathway" RELATED [GOC:TermGenie]
synonym: "down-regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "down-regulation of signal transmission via intracellular cascade" RELATED [GOC:TermGenie]
synonym: "downregulation of intracellular signal transduction" EXACT [GOC:TermGenie]
synonym: "downregulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "downregulation of intracellular signaling cascade" NARROW [GOC:TermGenie]
synonym: "downregulation of intracellular signaling chain" EXACT [GOC:TermGenie]
synonym: "downregulation of intracellular signaling pathway" RELATED [GOC:TermGenie]
synonym: "downregulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "downregulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie]
synonym: "inhibition of intracellular signal transduction" NARROW [GOC:TermGenie]
synonym: "inhibition of intracellular signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of intracellular signaling cascade" NARROW [GOC:TermGenie]
synonym: "inhibition of intracellular signaling chain" NARROW [GOC:TermGenie]
synonym: "inhibition of intracellular signaling pathway" RELATED [GOC:TermGenie]
synonym: "inhibition of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "inhibition of signal transmission via intracellular cascade" NARROW [GOC:TermGenie]
synonym: "negative regulation of intracellular protein kinase cascade" EXACT []
synonym: "negative regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of intracellular signaling cascade" EXACT [GOC:TermGenie]
synonym: "negative regulation of intracellular signaling chain" EXACT [GOC:TermGenie]
synonym: "negative regulation of intracellular signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "negative regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:1902531 ! regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035556 ! intracellular signal transduction
relationship: negatively_regulates GO:0035556 ! intracellular signal transduction
created_by: bf
creation_date: 2013-12-02T11:33:01Z

[Term]
id: GO:1902533
name: positive regulation of intracellular signal transduction
namespace: biological_process
alt_id: GO:0010740
def: "Any process that activates or increases the frequency, rate or extent of intracellular signal transduction." [GOC:BHF, GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]
synonym: "activation of intracellular signal transduction" NARROW [GOC:TermGenie]
synonym: "activation of intracellular signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "activation of intracellular signaling cascade" NARROW [GOC:TermGenie]
synonym: "activation of intracellular signaling chain" NARROW [GOC:TermGenie]
synonym: "activation of intracellular signaling pathway" RELATED [GOC:TermGenie]
synonym: "activation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "activation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie]
synonym: "positive regulation of intracellular protein kinase cascade" NARROW []
synonym: "positive regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "positive regulation of intracellular signaling chain" EXACT [GOC:TermGenie]
synonym: "positive regulation of intracellular signaling pathway" RELATED [GOC:TermGenie]
synonym: "positive regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "positive regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie]
synonym: "up regulation of intracellular signal transduction" EXACT [GOC:TermGenie]
synonym: "up regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "up regulation of intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "up regulation of intracellular signaling chain" EXACT [GOC:TermGenie]
synonym: "up regulation of intracellular signaling pathway" RELATED [GOC:TermGenie]
synonym: "up regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "up regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie]
synonym: "up-regulation of intracellular signal transduction" EXACT [GOC:TermGenie]
synonym: "up-regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "up-regulation of intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "up-regulation of intracellular signaling chain" EXACT [GOC:TermGenie]
synonym: "up-regulation of intracellular signaling pathway" RELATED [GOC:TermGenie]
synonym: "up-regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "up-regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie]
synonym: "upregulation of intracellular signal transduction" EXACT [GOC:TermGenie]
synonym: "upregulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "upregulation of intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "upregulation of intracellular signaling chain" EXACT [GOC:TermGenie]
synonym: "upregulation of intracellular signaling pathway" RELATED [GOC:TermGenie]
synonym: "upregulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "upregulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:1902531 ! regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035556 ! intracellular signal transduction
relationship: positively_regulates GO:0035556 ! intracellular signal transduction
created_by: bf
creation_date: 2013-12-02T11:33:10Z

[Term]
id: GO:1902534
name: single-organism membrane invagination
namespace: biological_process
def: "A membrane invagination which involves only one organism." [GOC:bf, GOC:jl, GOC:TermGenie]
is_a: GO:0010324 ! membrane invagination
is_a: GO:0044802 ! single-organism membrane organization
created_by: jl
creation_date: 2013-12-02T13:58:34Z

[Term]
id: GO:1902535
name: multi-organism membrane invagination
namespace: biological_process
def: "A membrane invagination which involves another organism." [GOC:bf, GOC:jl, GOC:TermGenie]
is_a: GO:0010324 ! membrane invagination
is_a: GO:0044803 ! multi-organism membrane organization
created_by: jl
creation_date: 2013-12-02T13:58:43Z

[Term]
id: GO:1902536
name: single-organism pinocytosis
namespace: biological_process
def: "A pinocytosis which involves only one organism." [GOC:bf, GOC:jl, GOC:TermGenie]
is_a: GO:0006907 ! pinocytosis
is_a: GO:0044765 ! single-organism transport
created_by: jl
creation_date: 2013-12-02T14:14:38Z

[Term]
id: GO:1902537
name: multi-organism pinocytosis
namespace: biological_process
def: "A pinocytosis which involves another organism." [GOC:bf, GOC:jl, GOC:TermGenie]
is_a: GO:0006907 ! pinocytosis
is_a: GO:0044766 ! multi-organism transport
created_by: jl
creation_date: 2013-12-02T14:14:46Z

[Term]
id: GO:1902538
name: single-organism macropinocytosis
namespace: biological_process
def: "A macropinocytosis which involves only one organism." [GOC:bf, GOC:jl, GOC:TermGenie]
is_a: GO:0044351 ! macropinocytosis
is_a: GO:1902536 ! single-organism pinocytosis
created_by: jl
creation_date: 2013-12-02T14:22:57Z

[Term]
id: GO:1902539
name: multi-organism macropinocytosis
namespace: biological_process
def: "A macropinocytosis which involves another organism." [GOC:bf, GOC:jl, GOC:TermGenie]
is_a: GO:0044351 ! macropinocytosis
is_a: GO:1902537 ! multi-organism pinocytosis
created_by: jl
creation_date: 2013-12-02T14:23:06Z

[Term]
id: GO:1902540
name: single-organism micropinocytosis
namespace: biological_process
def: "A micropinocytosis which involves only one organism." [GOC:bf, GOC:jl, GOC:TermGenie]
is_a: GO:0044350 ! micropinocytosis
is_a: GO:1902536 ! single-organism pinocytosis
created_by: bf
creation_date: 2013-12-02T14:26:30Z

[Term]
id: GO:1902541
name: multi-organism micropinocytosis
namespace: biological_process
def: "A micropinocytosis which involves another organism." [GOC:bf, GOC:jl, GOC:TermGenie]
is_a: GO:0044350 ! micropinocytosis
is_a: GO:1902537 ! multi-organism pinocytosis
created_by: bf
creation_date: 2013-12-02T14:26:39Z

[Term]
id: GO:1902542
name: regulation of protein localization to mitotic spindle pole body
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to mitotic spindle pole body." [GOC:TermGenie, PMID:22809626]
synonym: "regulation of protein localisation to mitotic spindle pole body" EXACT [GOC:TermGenie]
is_a: GO:1902363 ! regulation of protein localization to spindle pole body
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1902440 ! protein localization to mitotic spindle pole body
relationship: regulates GO:1902440 ! protein localization to mitotic spindle pole body
created_by: al
creation_date: 2013-12-04T13:47:09Z

[Term]
id: GO:1902543
name: negative regulation of protein localization to mitotic spindle pole body
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to mitotic spindle pole body." [GOC:TermGenie, PMID:22809626]
synonym: "down regulation of protein localisation to mitotic spindle pole body" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to mitotic spindle pole body" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation in mitotic spindle pole body" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation to mitotic spindle pole body" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to mitotic spindle pole body" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation to mitotic spindle pole body" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to mitotic spindle pole body" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localisation to mitotic spindle pole body" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to mitotic spindle pole body" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation to mitotic spindle pole body" EXACT [GOC:TermGenie]
is_a: GO:1902364 ! negative regulation of protein localization to spindle pole body
is_a: GO:1902542 ! regulation of protein localization to mitotic spindle pole body
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1902440 ! protein localization to mitotic spindle pole body
relationship: negatively_regulates GO:1902440 ! protein localization to mitotic spindle pole body
created_by: al
creation_date: 2013-12-04T13:47:18Z

[Term]
id: GO:1902544
name: regulation of DNA N-glycosylase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA N-glycosylase activity." [GOC:rph, GOC:TermGenie, PMID:15518571]
synonym: "regulation of DNA glycosylase activity" EXACT [GOC:TermGenie]
synonym: "regulation of endonuclease VIII activity" RELATED [GOC:TermGenie]
is_a: GO:0051336 ! regulation of hydrolase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019104 ! DNA N-glycosylase activity
relationship: regulates GO:0019104 ! DNA N-glycosylase activity
created_by: rph
creation_date: 2013-12-04T14:17:54Z

[Term]
id: GO:1902545
name: negative regulation of DNA N-glycosylase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA N-glycosylase activity." [GOC:rph, GOC:TermGenie, PMID:15518571]
synonym: "down regulation of DNA glycosylase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of DNA N-glycosylase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of endonuclease VIII activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of DNA glycosylase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA N-glycosylase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of endonuclease VIII activity" RELATED [GOC:TermGenie]
synonym: "downregulation of DNA glycosylase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA N-glycosylase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of endonuclease VIII activity" RELATED [GOC:TermGenie]
synonym: "inhibition of DNA glycosylase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA N-glycosylase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of endonuclease VIII activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of DNA glycosylase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of endonuclease VIII activity" RELATED [GOC:TermGenie]
is_a: GO:0051346 ! negative regulation of hydrolase activity
is_a: GO:1902544 ! regulation of DNA N-glycosylase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019104 ! DNA N-glycosylase activity
relationship: negatively_regulates GO:0019104 ! DNA N-glycosylase activity
created_by: rph
creation_date: 2013-12-04T14:18:03Z

[Term]
id: GO:1902546
name: positive regulation of DNA N-glycosylase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA N-glycosylase activity." [GOC:rph, GOC:TermGenie, PMID:15518571]
synonym: "activation of DNA glycosylase activity" NARROW [GOC:TermGenie]
synonym: "activation of DNA N-glycosylase activity" NARROW [GOC:TermGenie]
synonym: "activation of endonuclease VIII activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of DNA glycosylase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of endonuclease VIII activity" RELATED [GOC:TermGenie]
synonym: "up regulation of DNA glycosylase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA N-glycosylase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of endonuclease VIII activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of DNA glycosylase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA N-glycosylase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of endonuclease VIII activity" RELATED [GOC:TermGenie]
synonym: "upregulation of DNA glycosylase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA N-glycosylase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of endonuclease VIII activity" RELATED [GOC:TermGenie]
is_a: GO:0051345 ! positive regulation of hydrolase activity
is_a: GO:1902544 ! regulation of DNA N-glycosylase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0019104 ! DNA N-glycosylase activity
relationship: positively_regulates GO:0019104 ! DNA N-glycosylase activity
created_by: rph
creation_date: 2013-12-04T14:18:12Z

[Term]
id: GO:1902547
name: regulation of cellular response to vascular endothelial growth factor stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular response to vascular endothelial growth factor stimulus." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17895370]
synonym: "regulation of cellular response to vascular endothelial growth factor" EXACT [GOC:TermGenie]
synonym: "regulation of cellular response to VEGF" EXACT [GOC:TermGenie]
synonym: "regulation of cellular response to VEGFA" NARROW [GOC:TermGenie]
synonym: "regulation of cellular response to VEGFB" NARROW [GOC:TermGenie]
is_a: GO:0090287 ! regulation of cellular response to growth factor stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035924 ! cellular response to vascular endothelial growth factor stimulus
relationship: regulates GO:0035924 ! cellular response to vascular endothelial growth factor stimulus
created_by: rl
creation_date: 2013-12-04T15:14:54Z

[Term]
id: GO:1902548
name: negative regulation of cellular response to vascular endothelial growth factor stimulus
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to vascular endothelial growth factor stimulus." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17895370]
comment: ADAMTS12 (UniProt ID P58397) in human in PMID:17895370 inhibits the formation of VEGF-induced tubular structures in BAE-1 cells (endothelial cell line).
synonym: "down regulation of cellular response to vascular endothelial growth factor" EXACT [GOC:TermGenie]
synonym: "down regulation of cellular response to vascular endothelial growth factor stimulus" EXACT [GOC:TermGenie]
synonym: "down regulation of cellular response to VEGF" EXACT [GOC:TermGenie]
synonym: "down regulation of cellular response to VEGFA" NARROW [GOC:TermGenie]
synonym: "down regulation of cellular response to VEGFB" NARROW [GOC:TermGenie]
synonym: "down-regulation of cellular response to vascular endothelial growth factor" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular response to vascular endothelial growth factor stimulus" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular response to VEGF" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular response to VEGFA" NARROW [GOC:TermGenie]
synonym: "down-regulation of cellular response to VEGFB" NARROW [GOC:TermGenie]
synonym: "downregulation of cellular response to vascular endothelial growth factor" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular response to vascular endothelial growth factor stimulus" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular response to VEGF" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular response to VEGFA" NARROW [GOC:TermGenie]
synonym: "downregulation of cellular response to VEGFB" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular response to vascular endothelial growth factor" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular response to vascular endothelial growth factor stimulus" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular response to VEGF" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular response to VEGFA" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular response to VEGFB" NARROW [GOC:TermGenie]
synonym: "negative regulation of cellular response to vascular endothelial growth factor" EXACT [GOC:TermGenie]
synonym: "negative regulation of cellular response to VEGF" EXACT [GOC:TermGenie]
synonym: "negative regulation of cellular response to VEGFA" NARROW [GOC:TermGenie]
synonym: "negative regulation of cellular response to VEGFB" NARROW [GOC:TermGenie]
is_a: GO:0090288 ! negative regulation of cellular response to growth factor stimulus
is_a: GO:1902547 ! regulation of cellular response to vascular endothelial growth factor stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035924 ! cellular response to vascular endothelial growth factor stimulus
relationship: negatively_regulates GO:0035924 ! cellular response to vascular endothelial growth factor stimulus
created_by: rl
creation_date: 2013-12-04T15:15:03Z

[Term]
id: GO:1902549
name: protein localization to Mei2 nuclear dot
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a Mei2 nuclear dot." [GOC:TermGenie, PMID:23980030]
synonym: "protein localisation in Mei2 nuclear dot" EXACT [GOC:TermGenie]
synonym: "protein localisation to Mei2 nuclear dot" EXACT [GOC:TermGenie]
synonym: "protein localization in Mei2 nuclear dot" EXACT [GOC:TermGenie]
synonym: "protein localization to Mei2 dot" EXACT []
is_a: GO:0034504 ! protein localization to nucleus
created_by: mah
creation_date: 2013-12-04T16:17:06Z

[Term]
id: GO:1902550
name: lymphoid lineage cell migration into thymus involved in thymus epithelium morphogenesis
namespace: biological_process
def: "Any lymphoid lineage cell migration into thymus that is involved in thymus epithelium morphogenesis." [GOC:cvs, GOC:TermGenie, PMID:22342843]
synonym: "lymphoid lineage cell migration into thymus involved in thymic epithelium morphogenesis" EXACT [GOC:TermGenie]
synonym: "lymphoid lineage restricted progenitor cell migration into thymus involved in thymic epithelium morphogenesis" EXACT [GOC:TermGenie]
synonym: "lymphoid lineage restricted progenitor cell migration into thymus involved in thymus epithelium morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:0097535 ! lymphoid lineage cell migration into thymus
intersection_of: GO:0097535 ! lymphoid lineage cell migration into thymus
intersection_of: part_of GO:0097536 ! thymus epithelium morphogenesis
relationship: part_of GO:0097536 ! thymus epithelium morphogenesis
created_by: pr
creation_date: 2013-12-04T21:13:33Z

[Term]
id: GO:1902551
name: regulation of catalase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of catalase activity." [GOC:TermGenie, PMID:24285797]
synonym: "regulation of bacterial catalase-peroxidase activity" NARROW [GOC:TermGenie]
synonym: "regulation of caperase activity" EXACT [GOC:TermGenie]
synonym: "regulation of CAT" RELATED [GOC:TermGenie]
synonym: "regulation of catalase reaction" EXACT [GOC:TermGenie]
synonym: "regulation of catalase-peroxidase activity" EXACT [GOC:TermGenie]
synonym: "regulation of equilase activity" EXACT [GOC:TermGenie]
synonym: "regulation of haem catalase activity" NARROW [GOC:TermGenie]
synonym: "regulation of heme catalase activity" NARROW [GOC:TermGenie]
synonym: "regulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of manganese catalase activity" NARROW [GOC:TermGenie]
synonym: "regulation of optidase activity" EXACT [GOC:TermGenie]
is_a: GO:2000468 ! regulation of peroxidase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004096 ! catalase activity
relationship: regulates GO:0004096 ! catalase activity
created_by: tb
creation_date: 2013-12-04T21:55:46Z

[Term]
id: GO:1902552
name: negative regulation of catalase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of catalase activity." [GOC:TermGenie, PMID:24285797]
synonym: "down regulation of bacterial catalase-peroxidase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of caperase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of CAT" RELATED [GOC:TermGenie]
synonym: "down regulation of catalase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of catalase reaction" EXACT [GOC:TermGenie]
synonym: "down regulation of catalase-peroxidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of equilase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of haem catalase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of heme catalase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of manganese catalase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of optidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of bacterial catalase-peroxidase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of caperase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of CAT" RELATED [GOC:TermGenie]
synonym: "down-regulation of catalase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of catalase reaction" EXACT [GOC:TermGenie]
synonym: "down-regulation of catalase-peroxidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of equilase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of haem catalase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of heme catalase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of manganese catalase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of optidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of bacterial catalase-peroxidase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of caperase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of CAT" RELATED [GOC:TermGenie]
synonym: "downregulation of catalase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of catalase reaction" EXACT [GOC:TermGenie]
synonym: "downregulation of catalase-peroxidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of equilase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of haem catalase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of heme catalase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of manganese catalase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of optidase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of bacterial catalase-peroxidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of caperase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of CAT" RELATED [GOC:TermGenie]
synonym: "inhibition of catalase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of catalase reaction" NARROW [GOC:TermGenie]
synonym: "inhibition of catalase-peroxidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of equilase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of haem catalase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of heme catalase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of manganese catalase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of optidase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of bacterial catalase-peroxidase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of caperase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of CAT" RELATED [GOC:TermGenie]
synonym: "negative regulation of catalase reaction" EXACT [GOC:TermGenie]
synonym: "negative regulation of catalase-peroxidase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of equilase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of haem catalase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of heme catalase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of manganese catalase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of optidase activity" EXACT [GOC:TermGenie]
is_a: GO:1902551 ! regulation of catalase activity
is_a: GO:2000469 ! negative regulation of peroxidase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004096 ! catalase activity
relationship: negatively_regulates GO:0004096 ! catalase activity
created_by: tb
creation_date: 2013-12-04T21:55:55Z

[Term]
id: GO:1902553
name: positive regulation of catalase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of catalase activity." [GOC:TermGenie, PMID:24285797]
synonym: "activation of bacterial catalase-peroxidase activity" NARROW [GOC:TermGenie]
synonym: "activation of caperase activity" NARROW [GOC:TermGenie]
synonym: "activation of CAT" RELATED [GOC:TermGenie]
synonym: "activation of catalase activity" NARROW [GOC:TermGenie]
synonym: "activation of catalase reaction" NARROW [GOC:TermGenie]
synonym: "activation of catalase-peroxidase activity" NARROW [GOC:TermGenie]
synonym: "activation of equilase activity" NARROW [GOC:TermGenie]
synonym: "activation of haem catalase activity" NARROW [GOC:TermGenie]
synonym: "activation of heme catalase activity" NARROW [GOC:TermGenie]
synonym: "activation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "activation of manganese catalase activity" NARROW [GOC:TermGenie]
synonym: "activation of optidase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of bacterial catalase-peroxidase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of caperase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of CAT" RELATED [GOC:TermGenie]
synonym: "positive regulation of catalase reaction" EXACT [GOC:TermGenie]
synonym: "positive regulation of catalase-peroxidase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of equilase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of haem catalase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of heme catalase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of manganese catalase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of optidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of bacterial catalase-peroxidase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of caperase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of CAT" RELATED [GOC:TermGenie]
synonym: "up regulation of catalase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of catalase reaction" EXACT [GOC:TermGenie]
synonym: "up regulation of catalase-peroxidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of equilase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of haem catalase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of heme catalase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of manganese catalase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of optidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of bacterial catalase-peroxidase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of caperase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of CAT" RELATED [GOC:TermGenie]
synonym: "up-regulation of catalase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of catalase reaction" EXACT [GOC:TermGenie]
synonym: "up-regulation of catalase-peroxidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of equilase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of haem catalase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of heme catalase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of manganese catalase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of optidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of bacterial catalase-peroxidase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of caperase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of CAT" RELATED [GOC:TermGenie]
synonym: "upregulation of catalase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of catalase reaction" EXACT [GOC:TermGenie]
synonym: "upregulation of catalase-peroxidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of equilase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of haem catalase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of heme catalase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of manganese catalase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of optidase activity" EXACT [GOC:TermGenie]
is_a: GO:1902551 ! regulation of catalase activity
is_a: GO:2000470 ! positive regulation of peroxidase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004096 ! catalase activity
relationship: positively_regulates GO:0004096 ! catalase activity
created_by: tb
creation_date: 2013-12-04T21:56:03Z

[Term]
id: GO:1902554
name: serine/threonine protein kinase complex
namespace: cellular_component
def: "A protein complex which is capable of protein serine/threonine kinase activity." [GOC:bhm, GOC:TermGenie, PMID:18191223]
comment: An example is IRE1 in S. cerevisiae (UniProt ID P32361) in PMID:18191223 (inferred from direct assay).
synonym: "PDR16 complex dimer" RELATED []
synonym: "PDR16 complex homodimer" RELATED []
is_a: GO:1902911 ! protein kinase complex
created_by: bhm
creation_date: 2013-12-06T16:06:12Z

[Term]
id: GO:1902555
name: endoribonuclease complex
namespace: cellular_component
def: "A protein complex which is capable of endoribonuclease activity." [GOC:bhm, GOC:TermGenie, PMID:18191223]
comment: An example is IRE1 in S. cerevisiae (UniProt ID P32361) in PMID:18191223 (inferred from direct assay).
synonym: "Ire1 complex dimer" RELATED []
synonym: "Ire1 complex homodimer" RELATED []
synonym: "Ire1 complex homooligomer" RELATED []
is_a: GO:1902494 ! catalytic complex
created_by: bhm
creation_date: 2013-12-06T16:09:31Z

[Term]
id: GO:1902556
name: phosphatidylinositol transporter complex
namespace: cellular_component
def: "A protein complex which is capable of phosphatidylinositol transporter activity." [GOC:bhm, GOC:TermGenie, PMID:9890948]
comment: An example is PDR16 in S. cerevisiae (UniProt ID P53860) in PMID:9890948 (inferred from direct assay).
synonym: "Ire1 complex dimer" RELATED []
synonym: "Ire1 complex homodimer" RELATED []
synonym: "Ire1 complex homooligomer" RELATED []
is_a: GO:1990351 ! transporter complex
created_by: bhm
creation_date: 2013-12-06T16:12:25Z

[Term]
id: GO:1902557
name: 5'-adenylyl sulfate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of 5'-adenylyl sulfate from one side of the membrane to the other." [GOC:TermGenie, PMID:24296033]
comment: An example of this is the YPR011C gene product in S. cerevisiae in PMID:24296033.
is_a: GO:0000295 ! adenine nucleotide transmembrane transporter activity
is_a: GO:0005346 ! purine ribonucleotide transmembrane transporter activity
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015211 ! purine nucleoside transmembrane transporter activity
is_a: GO:1901682 ! sulfur compound transmembrane transporter activity
relationship: part_of GO:1902558 ! 5'-adenylyl sulfate transmembrane transport
created_by: mcc
creation_date: 2013-12-09T23:08:05Z

[Term]
id: GO:1902558
name: 5'-adenylyl sulfate transmembrane transport
namespace: biological_process
def: "The directed movement of 5'-adenylyl sulfate across a membrane." [GOC:TermGenie, PMID:24296033]
synonym: "adenosine 5'-phosphosulfate transmembrane transport" EXACT [PMID:24296033]
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015860 ! purine nucleoside transmembrane transport
is_a: GO:0015868 ! purine ribonucleotide transport
is_a: GO:0051503 ! adenine nucleotide transport
is_a: GO:0072348 ! sulfur compound transport
is_a: GO:0098656 ! anion transmembrane transport
is_a: GO:1901679 ! nucleotide transmembrane transport
created_by: mcc
creation_date: 2013-12-09T23:16:01Z

[Term]
id: GO:1902559
name: 3'-phospho-5'-adenylyl sulfate transmembrane transport
namespace: biological_process
def: "The directed movement of 3'-phospho-5'-adenylyl sulfate across a membrane." [GOC:TermGenie, PMID:24296033]
synonym: "3'-phosphoadenosine 5'-phosphosulfate transmembrane transport" EXACT [PMID:24296033]
is_a: GO:0015860 ! purine nucleoside transmembrane transport
is_a: GO:0046963 ! 3'-phosphoadenosine 5'-phosphosulfate transport
is_a: GO:0098656 ! anion transmembrane transport
is_a: GO:1901679 ! nucleotide transmembrane transport
created_by: mcc
creation_date: 2013-12-09T23:19:04Z

[Term]
id: GO:1902560
name: GMP reductase complex
namespace: cellular_component
def: "A protein complex which is capable of GMP reductase activity. It catalysis of the irreversible reaction: IMP + NADP(+) + NH(4)(+) <= GMP + 2 H(+) + NADPH." [GOC:bhm, GOC:TermGenie, PMID:12009299]
comment: An example of this is GMPR2 in human (UniProt Symbol Q9P2T1) in PMID:12009299 (inferred from direct assay).
synonym: "GMP reductase" NARROW []
synonym: "GMPR1 complex" NARROW []
synonym: "GMPR2 complex" NARROW []
synonym: "guanosine monophosphate reductase" NARROW []
xref: EC:1.7.1.7
xref: RHEA:17188
is_a: GO:1990204 ! oxidoreductase complex
created_by: bhm
creation_date: 2013-12-10T11:54:30Z

[Term]
id: GO:1902561
name: origin recognition complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an origin recognition complex." [GOC:TermGenie, PMID:11717425]
synonym: "ORC assembly" EXACT [GOC:TermGenie]
synonym: "ORC formation" EXACT [GOC:TermGenie]
synonym: "origin of replication recognition complex assembly" EXACT [GOC:TermGenie]
synonym: "origin of replication recognition complex formation" EXACT [GOC:TermGenie]
synonym: "origin recognition complex formation" EXACT [GOC:TermGenie]
is_a: GO:0006461 ! protein complex assembly
created_by: mah
creation_date: 2013-12-10T12:11:50Z

[Term]
id: GO:1902562
name: H4 histone acetyltransferase complex
namespace: cellular_component
def: "A protein complex which is capable of H4 histone acetyltransferase activity." [GOC:bhm, GOC:TermGenie, PMID:23775086]
comment: An example of this is Hpa2 in yeast [Q06592] in PMID:23775086 [IDA].
synonym: "Hpa3 (homo-)dimer" NARROW [PMID:23775086]
synonym: "Hpa3 complex" NARROW [PMID:23775086]
is_a: GO:0000123 ! histone acetyltransferase complex
created_by: bhm
creation_date: 2013-12-10T14:43:51Z

[Term]
id: GO:1902563
name: regulation of neutrophil activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neutrophil activation." [GOC:TermGenie, PMID:17588661]
is_a: GO:0002694 ! regulation of leukocyte activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042119 ! neutrophil activation
relationship: regulates GO:0042119 ! neutrophil activation
created_by: ecu
creation_date: 2013-12-10T15:33:08Z

[Term]
id: GO:1902564
name: negative regulation of neutrophil activation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of neutrophil activation." [GOC:TermGenie, PMID:17588661]
synonym: "down regulation of neutrophil activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of neutrophil activation" EXACT [GOC:TermGenie]
synonym: "downregulation of neutrophil activation" EXACT [GOC:TermGenie]
synonym: "inhibition of neutrophil activation" NARROW [GOC:TermGenie]
is_a: GO:0002695 ! negative regulation of leukocyte activation
is_a: GO:1902563 ! regulation of neutrophil activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042119 ! neutrophil activation
relationship: negatively_regulates GO:0042119 ! neutrophil activation
created_by: ecu
creation_date: 2013-12-10T15:33:16Z

[Term]
id: GO:1902565
name: positive regulation of neutrophil activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neutrophil activation." [GOC:TermGenie, PMID:17588661]
synonym: "activation of neutrophil activation" NARROW [GOC:TermGenie]
synonym: "up regulation of neutrophil activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of neutrophil activation" EXACT [GOC:TermGenie]
synonym: "upregulation of neutrophil activation" EXACT [GOC:TermGenie]
is_a: GO:0002696 ! positive regulation of leukocyte activation
is_a: GO:1902563 ! regulation of neutrophil activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042119 ! neutrophil activation
relationship: positively_regulates GO:0042119 ! neutrophil activation
created_by: ecu
creation_date: 2013-12-10T15:33:26Z

[Term]
id: GO:1902566
name: regulation of eosinophil activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of eosinophil activation." [GOC:TermGenie, PMID:16254138]
is_a: GO:0002694 ! regulation of leukocyte activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043307 ! eosinophil activation
relationship: regulates GO:0043307 ! eosinophil activation
created_by: ecu
creation_date: 2013-12-10T15:54:35Z

[Term]
id: GO:1902567
name: negative regulation of eosinophil activation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of eosinophil activation." [GOC:TermGenie, PMID:16254138]
synonym: "down regulation of eosinophil activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of eosinophil activation" EXACT [GOC:TermGenie]
synonym: "downregulation of eosinophil activation" EXACT [GOC:TermGenie]
synonym: "inhibition of eosinophil activation" NARROW [GOC:TermGenie]
is_a: GO:0002695 ! negative regulation of leukocyte activation
is_a: GO:1902566 ! regulation of eosinophil activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043307 ! eosinophil activation
relationship: negatively_regulates GO:0043307 ! eosinophil activation
created_by: ecu
creation_date: 2013-12-10T15:54:43Z

[Term]
id: GO:1902568
name: positive regulation of eosinophil activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of eosinophil activation." [GOC:TermGenie, PMID:16254138]
synonym: "activation of eosinophil activation" NARROW [GOC:TermGenie]
synonym: "up regulation of eosinophil activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of eosinophil activation" EXACT [GOC:TermGenie]
synonym: "upregulation of eosinophil activation" EXACT [GOC:TermGenie]
is_a: GO:0002696 ! positive regulation of leukocyte activation
is_a: GO:1902566 ! regulation of eosinophil activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043307 ! eosinophil activation
relationship: positively_regulates GO:0043307 ! eosinophil activation
created_by: ecu
creation_date: 2013-12-10T15:54:52Z

[Term]
id: GO:1902569
name: negative regulation of activation of JAK2 kinase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of activation of JAK2 kinase activity." [GOC:TermGenie, PMID:16254138]
synonym: "down regulation of activation of JAK2 kinase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of activation of JAK2 protein" EXACT [GOC:TermGenie]
synonym: "down regulation of tyrosine phosphorylation of JAK2 protein" RELATED [GOC:TermGenie]
synonym: "down-regulation of activation of JAK2 kinase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of activation of JAK2 protein" EXACT [GOC:TermGenie]
synonym: "down-regulation of tyrosine phosphorylation of JAK2 protein" RELATED [GOC:TermGenie]
synonym: "downregulation of activation of JAK2 kinase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of activation of JAK2 protein" EXACT [GOC:TermGenie]
synonym: "downregulation of tyrosine phosphorylation of JAK2 protein" RELATED [GOC:TermGenie]
synonym: "inhibition of activation of JAK2 kinase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of activation of JAK2 protein" NARROW [GOC:TermGenie]
synonym: "inhibition of tyrosine phosphorylation of JAK2 protein" RELATED [GOC:TermGenie]
synonym: "negative regulation of activation of JAK2 protein" EXACT [GOC:TermGenie]
synonym: "negative regulation of tyrosine phosphorylation of JAK2 protein" RELATED [GOC:TermGenie]
is_a: GO:0010534 ! regulation of activation of JAK2 kinase activity
is_a: GO:0050732 ! negative regulation of peptidyl-tyrosine phosphorylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042977 ! activation of JAK2 kinase activity
relationship: negatively_regulates GO:0042977 ! activation of JAK2 kinase activity
created_by: ecu
creation_date: 2013-12-10T16:13:20Z

[Term]
id: GO:1902570
name: protein localization to nucleolus
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a nucleolus." [GOC:TermGenie, PMID:22809626]
synonym: "protein localisation in nucleolus" EXACT [GOC:TermGenie]
synonym: "protein localisation to nucleolus" EXACT [GOC:TermGenie]
synonym: "protein localization in nucleolus" EXACT [GOC:TermGenie]
is_a: GO:0034504 ! protein localization to nucleus
created_by: mah
creation_date: 2013-12-10T16:25:28Z

[Term]
id: GO:1902571
name: regulation of serine-type peptidase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of serine-type peptidase activity." [GOC:krc, GOC:TermGenie, PMID:20179351]
synonym: "regulation of serine protease activity" NARROW [GOC:TermGenie]
is_a: GO:0052547 ! regulation of peptidase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008236 ! serine-type peptidase activity
relationship: regulates GO:0008236 ! serine-type peptidase activity
created_by: krc
creation_date: 2013-12-10T18:16:58Z

[Term]
id: GO:1902572
name: negative regulation of serine-type peptidase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of serine-type peptidase activity." [GOC:krc, GOC:TermGenie, PMID:20179351]
synonym: "down regulation of serine protease activity" NARROW [GOC:TermGenie]
synonym: "down regulation of serine-type peptidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of serine protease activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of serine-type peptidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of serine protease activity" NARROW [GOC:TermGenie]
synonym: "downregulation of serine-type peptidase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of serine protease activity" NARROW [GOC:TermGenie]
synonym: "inhibition of serine-type peptidase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of serine protease activity" NARROW [GOC:TermGenie]
is_a: GO:0010466 ! negative regulation of peptidase activity
is_a: GO:1902571 ! regulation of serine-type peptidase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008236 ! serine-type peptidase activity
relationship: negatively_regulates GO:0008236 ! serine-type peptidase activity
created_by: krc
creation_date: 2013-12-10T18:17:07Z

[Term]
id: GO:1902573
name: positive regulation of serine-type peptidase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of serine-type peptidase activity." [GOC:krc, GOC:TermGenie, PMID:20179351]
synonym: "activation of serine protease activity" NARROW [GOC:TermGenie]
synonym: "activation of serine-type peptidase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of serine protease activity" NARROW [GOC:TermGenie]
synonym: "up regulation of serine protease activity" NARROW [GOC:TermGenie]
synonym: "up regulation of serine-type peptidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of serine protease activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of serine-type peptidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of serine protease activity" NARROW [GOC:TermGenie]
synonym: "upregulation of serine-type peptidase activity" EXACT [GOC:TermGenie]
is_a: GO:0010952 ! positive regulation of peptidase activity
is_a: GO:1902571 ! regulation of serine-type peptidase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008236 ! serine-type peptidase activity
relationship: positively_regulates GO:0008236 ! serine-type peptidase activity
created_by: krc
creation_date: 2013-12-10T18:17:16Z

[Term]
id: GO:1902574
name: negative regulation of leucine import by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A regulation of transcription from RNA polymerase II promoter that results in negative regulation of leucine import." [GOC:TermGenie, PMID:22992726]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0060358 ! negative regulation of leucine import
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: regulates GO:0100065 ! negative regulation of leucine import by transcription from RNA polymerase II promoter
relationship: regulates GO:0100065 ! negative regulation of leucine import by transcription from RNA polymerase II promoter
created_by: al
creation_date: 2013-12-11T09:43:23Z

[Term]
id: GO:1902575
name: protein localization to cell division site involved in cytokinesis, actomyosin contractile ring assembly
namespace: biological_process
def: "Any protein localization to cell division site that is involved in cytokinesis, actomyosin contractile ring assembly." [GOC:al, GOC:TermGenie, PMID:24127216]
synonym: "protein localisation to cell division site involved in constriction ring assembly" NARROW [GOC:TermGenie]
synonym: "protein localisation to cell division site involved in contractile ring assembly" EXACT [GOC:TermGenie]
synonym: "protein localisation to cell division site involved in cytokinesis, actomyosin contractile ring assembly" EXACT [GOC:TermGenie]
synonym: "protein localisation to cell division site involved in cytokinesis, actomyosin contractile ring formation" RELATED [GOC:TermGenie]
synonym: "protein localisation to cell division site involved in cytokinesis, actomyosin ring biosynthesis" RELATED [GOC:TermGenie]
synonym: "protein localisation to cell division site involved in cytokinesis, actomyosin ring formation" RELATED [GOC:TermGenie]
synonym: "protein localisation to cell division site involved in cytokinesis, contractile ring assembly" RELATED [GOC:TermGenie]
synonym: "protein localization to cell division site involved in constriction ring assembly" NARROW [GOC:TermGenie]
synonym: "protein localization to cell division site involved in contractile ring assembly" EXACT [GOC:TermGenie]
synonym: "protein localization to cell division site involved in cytokinesis, actomyosin contractile ring formation" RELATED [GOC:TermGenie]
synonym: "protein localization to cell division site involved in cytokinesis, actomyosin ring biosynthesis" RELATED [GOC:TermGenie]
synonym: "protein localization to cell division site involved in cytokinesis, actomyosin ring formation" RELATED [GOC:TermGenie]
synonym: "protein localization to cell division site involved in cytokinesis, contractile ring assembly" RELATED [GOC:TermGenie]
is_a: GO:0022402 ! cell cycle process
is_a: GO:0072741 ! protein localization to cell division site
is_a: GO:1902580 ! single-organism cellular localization
intersection_of: GO:0072741 ! protein localization to cell division site
intersection_of: part_of GO:0000915 ! actomyosin contractile ring assembly
relationship: part_of GO:0000915 ! actomyosin contractile ring assembly
created_by: bf
creation_date: 2013-12-16T10:42:25Z

[Term]
id: GO:1902576
name: negative regulation of nuclear cell cycle DNA replication
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of nuclear cell cycle DNA replication." [GOC:TermGenie, PMID:19033384]
synonym: "down regulation of DNA replication during S phase" RELATED [GOC:TermGenie]
synonym: "down regulation of DNA replication involved in S phase" EXACT [GOC:TermGenie]
synonym: "down regulation of DNA replication involved in S-phase" EXACT [GOC:TermGenie]
synonym: "down regulation of nuclear cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA replication during S phase" RELATED [GOC:TermGenie]
synonym: "down-regulation of DNA replication involved in S phase" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA replication involved in S-phase" EXACT [GOC:TermGenie]
synonym: "down-regulation of nuclear cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA replication during S phase" RELATED [GOC:TermGenie]
synonym: "downregulation of DNA replication involved in S phase" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA replication involved in S-phase" EXACT [GOC:TermGenie]
synonym: "downregulation of nuclear cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "inhibition of DNA replication during S phase" RELATED [GOC:TermGenie]
synonym: "inhibition of DNA replication involved in S phase" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA replication involved in S-phase" NARROW [GOC:TermGenie]
synonym: "inhibition of nuclear cell cycle DNA replication" NARROW [GOC:TermGenie]
synonym: "negative regulation of DNA replication during S phase" RELATED [GOC:TermGenie]
synonym: "negative regulation of DNA replication involved in S phase" EXACT [GOC:TermGenie]
synonym: "negative regulation of DNA replication involved in S-phase" EXACT [GOC:TermGenie]
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0033262 ! regulation of nuclear cell cycle DNA replication
is_a: GO:2000104 ! negative regulation of DNA-dependent DNA replication
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0033260 ! nuclear DNA replication
relationship: negatively_regulates GO:0033260 ! nuclear DNA replication
created_by: mah
creation_date: 2013-12-17T14:03:02Z

[Term]
id: GO:1902577
name: protein localization to medial cortical node
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a medial cortical node." [GOC:TermGenie, PMID:24127216]
synonym: "protein localisation in medial cortical node" EXACT [GOC:TermGenie]
synonym: "protein localisation to medial cortical node" EXACT [GOC:TermGenie]
synonym: "protein localization in medial cortical node" EXACT [GOC:TermGenie]
is_a: GO:0071574 ! protein localization to medial cortex
created_by: mah
creation_date: 2013-12-17T14:09:28Z

[Term]
id: GO:1902578
name: single-organism localization
namespace: biological_process
def: "A localization which involves only one organism." [GO_REF:0000089, GOC:jl, PMID:1234]
synonym: "single organism localization" EXACT [GOC:TermGenie]
is_a: GO:0044699 ! single-organism process
is_a: GO:0051179 ! localization
created_by: jl
creation_date: 2013-12-18T13:51:04Z

[Term]
id: GO:1902579
name: multi-organism localization
namespace: biological_process
def: "A localization which involves another organism." [GO_REF:0000089, GOC:jl, GOC:TermGenie]
synonym: "multi organism localization" EXACT [GOC:TermGenie]
is_a: GO:0051179 ! localization
is_a: GO:0051704 ! multi-organism process
created_by: jl
creation_date: 2013-12-18T13:51:13Z

[Term]
id: GO:1902580
name: single-organism cellular localization
namespace: biological_process
def: "A cellular localization which involves only one organism." [GO_REF:0000089, GOC:jl, GOC:TermGenie]
synonym: "single organism cellular localization" EXACT [GOC:TermGenie]
is_a: GO:0051641 ! cellular localization
is_a: GO:1902578 ! single-organism localization
created_by: jl
creation_date: 2013-12-18T14:04:32Z

[Term]
id: GO:1902581
name: multi-organism cellular localization
namespace: biological_process
def: "A cellular localization which involves another organism." [GO_REF:0000089, GOC:jl, GOC:TermGenie]
synonym: "multi organism cellular localization" EXACT [GOC:TermGenie]
is_a: GO:0051641 ! cellular localization
is_a: GO:1902579 ! multi-organism localization
created_by: jl
creation_date: 2013-12-18T14:04:41Z

[Term]
id: GO:1902582
name: single-organism intracellular transport
namespace: biological_process
def: "An intracellular transport which involves only one organism." [GO_REF:0000089, GOC:jl, GOC:TermGenie]
synonym: "single organism intracellular transport" EXACT [GOC:TermGenie]
is_a: GO:0044765 ! single-organism transport
is_a: GO:0046907 ! intracellular transport
created_by: jl
creation_date: 2013-12-18T14:04:50Z

[Term]
id: GO:1902583
name: multi-organism intracellular transport
namespace: biological_process
def: "An intracellular transport which involves another organism." [GO_REF:0000089, GOC:jl, GOC:TermGenie]
synonym: "multi organism intracellular transport" EXACT [GOC:TermGenie]
is_a: GO:0044766 ! multi-organism transport
is_a: GO:0046907 ! intracellular transport
created_by: jl
creation_date: 2013-12-18T14:04:58Z

[Term]
id: GO:1902584
name: positive regulation of response to water deprivation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to water deprivation." [GO_REF:0000058, GOC:TermGenie, PMID:24198318]
synonym: "activation of drought tolerance" RELATED [GOC:TermGenie]
synonym: "activation of response to dehydration" NARROW [GOC:TermGenie]
synonym: "activation of response to drought" NARROW [GOC:TermGenie]
synonym: "activation of response to thirst" NARROW [GOC:TermGenie]
synonym: "activation of response to water deprivation" NARROW [GOC:TermGenie]
synonym: "positive regulation of drought tolerance" RELATED [GOC:TermGenie]
synonym: "positive regulation of response to dehydration" EXACT [GOC:TermGenie]
synonym: "positive regulation of response to drought" EXACT [GOC:TermGenie]
synonym: "positive regulation of response to thirst" EXACT [GOC:TermGenie]
synonym: "up regulation of drought tolerance" RELATED [GOC:TermGenie]
synonym: "up regulation of response to dehydration" EXACT [GOC:TermGenie]
synonym: "up regulation of response to drought" EXACT [GOC:TermGenie]
synonym: "up regulation of response to thirst" EXACT [GOC:TermGenie]
synonym: "up regulation of response to water deprivation" EXACT [GOC:TermGenie]
synonym: "up-regulation of drought tolerance" RELATED [GOC:TermGenie]
synonym: "up-regulation of response to dehydration" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to drought" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to thirst" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to water deprivation" EXACT [GOC:TermGenie]
synonym: "upregulation of drought tolerance" RELATED [GOC:TermGenie]
synonym: "upregulation of response to dehydration" EXACT [GOC:TermGenie]
synonym: "upregulation of response to drought" EXACT [GOC:TermGenie]
synonym: "upregulation of response to thirst" EXACT [GOC:TermGenie]
synonym: "upregulation of response to water deprivation" EXACT [GOC:TermGenie]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:2000070 ! regulation of response to water deprivation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009414 ! response to water deprivation
relationship: positively_regulates GO:0009414 ! response to water deprivation
created_by: tb
creation_date: 2013-12-19T00:31:58Z

[Term]
id: GO:1902585
name: single-organism intercellular transport
namespace: biological_process
def: "An intercellular transport which involves only one organism." [GO_REF:0000089, GOC:jl, GOC:TermGenie]
synonym: "single organism intercellular transport" EXACT [GOC:TermGenie]
is_a: GO:0010496 ! intercellular transport
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:0044765 ! single-organism transport
created_by: jl
creation_date: 2013-12-19T13:24:56Z

[Term]
id: GO:1902586
name: multi-organism intercellular transport
namespace: biological_process
def: "An intercellular transport which involves another organism." [GO_REF:0000089, GOC:jl, GOC:TermGenie]
synonym: "multi organism intercellular transport" EXACT [GOC:TermGenie]
is_a: GO:0010496 ! intercellular transport
is_a: GO:0044764 ! multi-organism cellular process
is_a: GO:0044766 ! multi-organism transport
created_by: jl
creation_date: 2013-12-19T13:25:05Z

[Term]
id: GO:1902587
name: single-organism plasmodesmata-mediated intercellular transport
namespace: biological_process
def: "A plasmodesmata-mediated intercellular transport which involves only one organism." [GO_REF:0000089, GOC:jl, GOC:TermGenie]
synonym: "single organism plasmodesmata-mediated intercellular transport" EXACT [GOC:TermGenie]
is_a: GO:0010497 ! plasmodesmata-mediated intercellular transport
is_a: GO:1902585 ! single-organism intercellular transport
created_by: jl
creation_date: 2013-12-19T13:37:36Z

[Term]
id: GO:1902588
name: multi-organism plasmodesmata-mediated intercellular transport
namespace: biological_process
def: "A plasmodesmata-mediated intercellular transport which involves another organism." [GO_REF:0000089, GOC:jl, GOC:TermGenie]
synonym: "multi organism plasmodesmata-mediated intercellular transport" EXACT [GOC:TermGenie]
is_a: GO:0010497 ! plasmodesmata-mediated intercellular transport
is_a: GO:1902586 ! multi-organism intercellular transport
created_by: jl
creation_date: 2013-12-19T13:37:53Z

[Term]
id: GO:1902589
name: single-organism organelle organization
namespace: biological_process
def: "An organelle organization which involves only one organism." [GO_REF:0000089, GOC:jl, GOC:TermGenie]
synonym: "single organism organelle organization" EXACT [GOC:TermGenie]
is_a: GO:0006996 ! organelle organization
is_a: GO:0044763 ! single-organism cellular process
created_by: jl
creation_date: 2013-12-19T15:25:51Z

[Term]
id: GO:1902590
name: multi-organism organelle organization
namespace: biological_process
def: "An organelle organization which involves another organism." [GO_REF:0000089, GOC:jl, GOC:TermGenie]
synonym: "multi organism organelle organization" EXACT [GOC:TermGenie]
is_a: GO:0006996 ! organelle organization
is_a: GO:0044764 ! multi-organism cellular process
created_by: jl
creation_date: 2013-12-19T15:26:08Z

[Term]
id: GO:1902591
name: single-organism membrane budding
namespace: biological_process
def: "A membrane budding which involves only one organism." [GO_REF:0000089, GOC:jl, GOC:TermGenie]
synonym: "single organism membrane budding" EXACT [GOC:TermGenie]
is_a: GO:0006900 ! membrane budding
is_a: GO:0044802 ! single-organism membrane organization
is_a: GO:1902589 ! single-organism organelle organization
created_by: jl
creation_date: 2013-12-19T15:26:17Z

[Term]
id: GO:1902592
name: multi-organism membrane budding
namespace: biological_process
def: "A membrane budding which involves another organism." [GO_REF:0000089, GOC:jl, GOC:TermGenie]
synonym: "multi organism membrane budding" EXACT [GOC:TermGenie]
is_a: GO:0006900 ! membrane budding
is_a: GO:0044803 ! multi-organism membrane organization
is_a: GO:1902590 ! multi-organism organelle organization
created_by: jl
creation_date: 2013-12-19T15:26:25Z

[Term]
id: GO:1902593
name: single-organism nuclear import
namespace: biological_process
def: "A nuclear import which involves only one organism." [GO_REF:0000089, GOC:jl, GOC:TermGenie]
synonym: "single organism nuclear import" EXACT [GOC:TermGenie]
is_a: GO:0051170 ! nuclear import
is_a: GO:1902582 ! single-organism intracellular transport
created_by: jl
creation_date: 2013-12-19T15:26:34Z

[Term]
id: GO:1902594
name: multi-organism nuclear import
namespace: biological_process
def: "A nuclear import which involves another organism." [GO_REF:0000089, GOC:jl, GOC:TermGenie]
synonym: "multi organism nuclear import" EXACT [GOC:TermGenie]
is_a: GO:0051170 ! nuclear import
is_a: GO:1902583 ! multi-organism intracellular transport
created_by: jl
creation_date: 2013-12-19T15:26:43Z

[Term]
id: GO:1902595
name: regulation of DNA replication origin binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA replication origin binding." [GO_REF:0000059, GOC:TermGenie, PMID:11850415]
synonym: "regulation of ARS binding" NARROW [GOC:TermGenie]
is_a: GO:0051101 ! regulation of DNA binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003688 ! DNA replication origin binding
relationship: regulates GO:0003688 ! DNA replication origin binding
created_by: mah
creation_date: 2013-12-19T16:19:39Z

[Term]
id: GO:1902596
name: negative regulation of DNA replication origin binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA replication origin binding." [GO_REF:0000059, GOC:TermGenie, PMID:11850415]
synonym: "down regulation of ARS binding" NARROW [GOC:TermGenie]
synonym: "down regulation of DNA replication origin binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of ARS binding" NARROW [GOC:TermGenie]
synonym: "down-regulation of DNA replication origin binding" EXACT [GOC:TermGenie]
synonym: "downregulation of ARS binding" NARROW [GOC:TermGenie]
synonym: "downregulation of DNA replication origin binding" EXACT [GOC:TermGenie]
synonym: "inhibition of ARS binding" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA replication origin binding" NARROW [GOC:TermGenie]
synonym: "negative regulation of ARS binding" NARROW [GOC:TermGenie]
is_a: GO:0043392 ! negative regulation of DNA binding
is_a: GO:1902595 ! regulation of DNA replication origin binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003688 ! DNA replication origin binding
relationship: negatively_regulates GO:0003688 ! DNA replication origin binding
created_by: mah
creation_date: 2013-12-19T16:19:48Z

[Term]
id: GO:1902597
name: positive regulation of DNA replication origin binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA replication origin binding." [GO_REF:0000059, GOC:TermGenie, PMID:11850415]
synonym: "activation of ARS binding" NARROW [GOC:TermGenie]
synonym: "activation of DNA replication origin binding" NARROW [GOC:TermGenie]
synonym: "positive regulation of ARS binding" NARROW [GOC:TermGenie]
synonym: "up regulation of ARS binding" NARROW [GOC:TermGenie]
synonym: "up regulation of DNA replication origin binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of ARS binding" NARROW [GOC:TermGenie]
synonym: "up-regulation of DNA replication origin binding" EXACT [GOC:TermGenie]
synonym: "upregulation of ARS binding" NARROW [GOC:TermGenie]
synonym: "upregulation of DNA replication origin binding" EXACT [GOC:TermGenie]
is_a: GO:0043388 ! positive regulation of DNA binding
is_a: GO:1902595 ! regulation of DNA replication origin binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003688 ! DNA replication origin binding
relationship: positively_regulates GO:0003688 ! DNA replication origin binding
created_by: mah
creation_date: 2013-12-19T16:19:57Z

[Term]
id: GO:1902598
name: creatine transmembrane transport
namespace: biological_process
def: "The directed movement of creatine across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]
is_a: GO:0003333 ! amino acid transmembrane transport
is_a: GO:0015881 ! creatine transport
created_by: pr
creation_date: 2013-12-20T11:01:18Z

[Term]
id: GO:1902599
name: sulfathiazole transmembrane transport
namespace: biological_process
def: "The directed movement of sulfathiazole across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]
is_a: GO:0006855 ! drug transmembrane transport
is_a: GO:0015906 ! sulfathiazole transport
created_by: pr
creation_date: 2013-12-20T11:08:28Z

[Term]
id: GO:1902600
name: hydrogen ion transmembrane transport
namespace: biological_process
def: "The directed movement of hydrogen ion (proton) across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]
synonym: "hydrogen transmembrane transport" BROAD []
synonym: "proton transmembrane transport" EXACT []
is_a: GO:0015992 ! proton transport
is_a: GO:0098662 ! inorganic cation transmembrane transport
created_by: pr
creation_date: 2013-12-20T11:08:37Z

[Term]
id: GO:1902601
name: silver ion transmembrane transport
namespace: biological_process
def: "The directed movement of silver ion across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]
synonym: "silver transmembrane transport" BROAD []
is_a: GO:0098660 ! inorganic ion transmembrane transport
created_by: pr
creation_date: 2013-12-20T11:08:46Z

[Term]
id: GO:1902602
name: aluminum ion transmembrane transport
namespace: biological_process
def: "The directed movement of aluminium ion across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]
synonym: "aluminium ion transmembrane transport" EXACT []
synonym: "aluminium transmembrane transport" BROAD []
synonym: "aluminum transmembrane transport" BROAD []
is_a: GO:0098660 ! inorganic ion transmembrane transport
created_by: pr
creation_date: 2013-12-20T11:09:01Z

[Term]
id: GO:1902603
name: carnitine transmembrane transport
namespace: biological_process
def: "The directed movement of carnitine across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]
is_a: GO:0015879 ! carnitine transport
is_a: GO:0072488 ! ammonium transmembrane transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport
created_by: pr
creation_date: 2013-12-20T11:09:11Z

[Term]
id: GO:1902604
name: p-aminobenzoyl-glutamate transmembrane transport
namespace: biological_process
def: "The directed movement of N-(4-aminobenzoyl)-L-glutamate across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]
synonym: "N-(4-aminobenzoyl)-L-glutamate transmembrane transport" EXACT []
is_a: GO:0003333 ! amino acid transmembrane transport
is_a: GO:0015814 ! p-aminobenzoyl-glutamate transport
is_a: GO:0035442 ! dipeptide transmembrane transport
created_by: pr
creation_date: 2013-12-20T11:09:20Z

[Term]
id: GO:1902605
name: heterotrimeric G-protein complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a heterotrimeric G-protein complex." [GO_REF:0000079, GOC:dph, GOC:TermGenie, PMID:23637185]
synonym: "heterotrimeric G-protein complex formation" EXACT [GOC:TermGenie]
synonym: "heterotrimeric G-protein GTPase activity assembly" RELATED [GOC:TermGenie]
synonym: "heterotrimeric G-protein GTPase activity formation" RELATED [GOC:TermGenie]
synonym: "heterotrimeric G-protein GTPase, alpha-subunit assembly" NARROW [GOC:TermGenie]
synonym: "heterotrimeric G-protein GTPase, alpha-subunit formation" NARROW [GOC:TermGenie]
synonym: "heterotrimeric G-protein GTPase, beta-subunit assembly" NARROW [GOC:TermGenie]
synonym: "heterotrimeric G-protein GTPase, beta-subunit formation" NARROW [GOC:TermGenie]
synonym: "heterotrimeric G-protein GTPase, gamma-subunit assembly" NARROW [GOC:TermGenie]
synonym: "heterotrimeric G-protein GTPase, gamma-subunit formation" NARROW [GOC:TermGenie]
is_a: GO:0006461 ! protein complex assembly
created_by: dph
creation_date: 2013-12-30T16:31:28Z

[Term]
id: GO:1902606
name: regulation of large conductance calcium-activated potassium channel activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of large conductance calcium-activated potassium channel activity." [GO_REF:0000059, GOC:TermGenie, PMID:23407708]
synonym: "regulation of BK calcium-activated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "regulation of BK channel activity" RELATED [GOC:TermGenie]
synonym: "regulation of BK KCa channels" EXACT [GOC:TermGenie]
synonym: "regulation of large conductance KCa channels" EXACT [GOC:TermGenie]
is_a: GO:1901016 ! regulation of potassium ion transmembrane transporter activity
is_a: GO:2001257 ! regulation of cation channel activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060072 ! large conductance calcium-activated potassium channel activity
relationship: regulates GO:0060072 ! large conductance calcium-activated potassium channel activity
created_by: sl
creation_date: 2014-01-02T18:51:03Z

[Term]
id: GO:1902607
name: negative regulation of large conductance calcium-activated potassium channel activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of large conductance calcium-activated potassium channel activity." [GO_REF:0000059, GOC:TermGenie, PMID:23407708]
synonym: "down regulation of BK calcium-activated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of BK channel activity" RELATED [GOC:TermGenie]
synonym: "down regulation of BK KCa channels" EXACT [GOC:TermGenie]
synonym: "down regulation of large conductance calcium-activated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of large conductance KCa channels" EXACT [GOC:TermGenie]
synonym: "down-regulation of BK calcium-activated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of BK channel activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of BK KCa channels" EXACT [GOC:TermGenie]
synonym: "down-regulation of large conductance calcium-activated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of large conductance KCa channels" EXACT [GOC:TermGenie]
synonym: "downregulation of BK calcium-activated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of BK channel activity" RELATED [GOC:TermGenie]
synonym: "downregulation of BK KCa channels" EXACT [GOC:TermGenie]
synonym: "downregulation of large conductance calcium-activated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of large conductance KCa channels" EXACT [GOC:TermGenie]
synonym: "inhibition of BK calcium-activated potassium channel activity" NARROW [GOC:TermGenie]
synonym: "inhibition of BK channel activity" RELATED [GOC:TermGenie]
synonym: "inhibition of BK KCa channels" NARROW [GOC:TermGenie]
synonym: "inhibition of large conductance calcium-activated potassium channel activity" NARROW [GOC:TermGenie]
synonym: "inhibition of large conductance KCa channels" NARROW [GOC:TermGenie]
synonym: "negative regulation of BK calcium-activated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of BK channel activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of BK KCa channels" EXACT [GOC:TermGenie]
synonym: "negative regulation of large conductance KCa channels" EXACT [GOC:TermGenie]
is_a: GO:1901017 ! negative regulation of potassium ion transmembrane transporter activity
is_a: GO:1902606 ! regulation of large conductance calcium-activated potassium channel activity
is_a: GO:2001258 ! negative regulation of cation channel activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060072 ! large conductance calcium-activated potassium channel activity
relationship: negatively_regulates GO:0060072 ! large conductance calcium-activated potassium channel activity
created_by: sl
creation_date: 2014-01-02T18:51:12Z

[Term]
id: GO:1902608
name: positive regulation of large conductance calcium-activated potassium channel activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of large conductance calcium-activated potassium channel activity." [GO_REF:0000059, GOC:TermGenie, PMID:23407708]
synonym: "activation of BK calcium-activated potassium channel activity" NARROW [GOC:TermGenie]
synonym: "activation of BK channel activity" RELATED [GOC:TermGenie]
synonym: "activation of BK KCa channels" NARROW [GOC:TermGenie]
synonym: "activation of large conductance calcium-activated potassium channel activity" NARROW [GOC:TermGenie]
synonym: "activation of large conductance KCa channels" NARROW [GOC:TermGenie]
synonym: "positive regulation of BK calcium-activated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of BK channel activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of BK KCa channels" EXACT [GOC:TermGenie]
synonym: "positive regulation of large conductance KCa channels" EXACT [GOC:TermGenie]
synonym: "up regulation of BK calcium-activated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of BK channel activity" RELATED [GOC:TermGenie]
synonym: "up regulation of BK KCa channels" EXACT [GOC:TermGenie]
synonym: "up regulation of large conductance calcium-activated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of large conductance KCa channels" EXACT [GOC:TermGenie]
synonym: "up-regulation of BK calcium-activated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of BK channel activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of BK KCa channels" EXACT [GOC:TermGenie]
synonym: "up-regulation of large conductance calcium-activated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of large conductance KCa channels" EXACT [GOC:TermGenie]
synonym: "upregulation of BK calcium-activated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of BK channel activity" RELATED [GOC:TermGenie]
synonym: "upregulation of BK KCa channels" EXACT [GOC:TermGenie]
synonym: "upregulation of large conductance calcium-activated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of large conductance KCa channels" EXACT [GOC:TermGenie]
is_a: GO:1901018 ! positive regulation of potassium ion transmembrane transporter activity
is_a: GO:1902606 ! regulation of large conductance calcium-activated potassium channel activity
is_a: GO:2001259 ! positive regulation of cation channel activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060072 ! large conductance calcium-activated potassium channel activity
relationship: positively_regulates GO:0060072 ! large conductance calcium-activated potassium channel activity
created_by: sl
creation_date: 2014-01-02T18:51:21Z

[Term]
id: GO:1902609
name: (R)-2-hydroxy-alpha-linolenic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (R)-2-hydroxy-alpha-linolenic acid." [GO_REF:0000068, GOC:TermGenie, PMID:24214535]
synonym: "(R)-2-hydroxy-alpha-linolenic acid anabolism" EXACT [GOC:TermGenie]
synonym: "(R)-2-hydroxy-alpha-linolenic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "(R)-2-hydroxy-alpha-linolenic acid formation" EXACT [GOC:TermGenie]
synonym: "(R)-2-hydroxy-alpha-linolenic acid synthesis" EXACT [GOC:TermGenie]
synonym: "2-hydroxy-octadecatrienoic acid biosynthesis" BROAD []
is_a: GO:0006636 ! unsaturated fatty acid biosynthetic process
is_a: GO:0042759 ! long-chain fatty acid biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process
created_by: tb
creation_date: 2014-01-08T01:14:03Z

[Term]
id: GO:1902610
name: response to N-phenylthiourea
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a N-phenylthiourea stimulus." [GO_REF:0000071, GOC:rjd, GOC:TermGenie, PMID:24006265]
is_a: GO:0010033 ! response to organic substance
created_by: rjd
creation_date: 2014-01-08T01:57:49Z

[Term]
id: GO:1902611
name: cellular response to N-phenylthiourea
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a N-phenylthiourea stimulus." [GO_REF:0000071, GOC:rjd, GOC:TermGenie, PMID:24006265]
is_a: GO:0070887 ! cellular response to chemical stimulus
is_a: GO:1902610 ! response to N-phenylthiourea
created_by: rjd
creation_date: 2014-01-08T01:57:58Z

[Term]
id: GO:1902612
name: regulation of anti-Mullerian hormone signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of anti-Mullerian hormone signaling pathway." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:23624077]
is_a: GO:0009966 ! regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990262 ! anti-Mullerian hormone signaling pathway
relationship: regulates GO:1990262 ! anti-Mullerian hormone signaling pathway
created_by: hjd
creation_date: 2014-01-09T15:39:30Z

[Term]
id: GO:1902613
name: negative regulation of anti-Mullerian hormone signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of anti-Mullerian hormone signaling pathway." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:23624077]
synonym: "down regulation of anti-Mullerian hormone signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of anti-Mullerian hormone signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of anti-Mullerian hormone signaling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of anti-Mullerian hormone signaling pathway" NARROW [GOC:TermGenie]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:1902612 ! regulation of anti-Mullerian hormone signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990262 ! anti-Mullerian hormone signaling pathway
relationship: negatively_regulates GO:1990262 ! anti-Mullerian hormone signaling pathway
created_by: hjd
creation_date: 2014-01-09T15:39:39Z

[Term]
id: GO:1902614
name: positive regulation of anti-Mullerian hormone signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of anti-Mullerian hormone signaling pathway." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:23624077]
synonym: "activation of anti-Mullerian hormone signaling pathway" NARROW [GOC:TermGenie]
synonym: "up regulation of anti-Mullerian hormone signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of anti-Mullerian hormone signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of anti-Mullerian hormone signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:1902612 ! regulation of anti-Mullerian hormone signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990262 ! anti-Mullerian hormone signaling pathway
relationship: positively_regulates GO:1990262 ! anti-Mullerian hormone signaling pathway
created_by: hjd
creation_date: 2014-01-09T15:39:48Z

[Term]
id: GO:1902615
name: immune response involved in response to exogenous dsRNA
namespace: biological_process
def: "Any immune response that is involved in response to exogenous dsRNA." [GO_REF:0000060, GOC:pg, GOC:TermGenie, PMID:21266579]
synonym: "immune response involved in response to exogenous double-stranded RNA" EXACT [GOC:TermGenie]
synonym: "immune response involved in response to viral dsRNA" NARROW [GOC:TermGenie]
is_a: GO:0006955 ! immune response
intersection_of: GO:0006955 ! immune response
intersection_of: part_of GO:0043330 ! response to exogenous dsRNA
relationship: part_of GO:0043330 ! response to exogenous dsRNA
created_by: tb
creation_date: 2014-01-10T01:29:25Z

[Term]
id: GO:1902616
name: acyl carnitine transmembrane transport
namespace: biological_process
def: "The directed movement of acyl carnitine across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]
synonym: "O-acylcarnitine transmembrane transport" EXACT []
is_a: GO:0006844 ! acyl carnitine transport
is_a: GO:0055085 ! transmembrane transport
created_by: pr
creation_date: 2014-01-10T11:07:30Z

[Term]
id: GO:1902617
name: response to fluoride
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluoride stimulus." [GO_REF:0000071, GOC:kmv, GOC:TermGenie, PMID:8138152]
is_a: GO:0001101 ! response to acid chemical
is_a: GO:0010035 ! response to inorganic substance
created_by: kmv
creation_date: 2014-01-10T19:41:49Z

[Term]
id: GO:1902618
name: cellular response to fluoride
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluoride stimulus." [GO_REF:0000071, GOC:kmv, GOC:TermGenie, PMID:8138152]
is_a: GO:0071229 ! cellular response to acid chemical
is_a: GO:1902617 ! response to fluoride
created_by: kmv
creation_date: 2014-01-10T19:41:58Z

[Term]
id: GO:1902619
name: regulation of microtubule minus-end binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of microtubule minus-end binding." [GO_REF:0000059, GOC:di, GOC:TermGenie, PMID:22939623]
is_a: GO:1904526 ! regulation of microtubule binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051011 ! microtubule minus-end binding
relationship: regulates GO:0051011 ! microtubule minus-end binding
created_by: tb
creation_date: 2014-01-14T22:17:16Z

[Term]
id: GO:1902620
name: positive regulation of microtubule minus-end binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of microtubule minus-end binding." [GO_REF:0000059, GOC:di, GOC:TermGenie, PMID:22939623]
synonym: "activation of microtubule minus-end binding" NARROW [GOC:TermGenie]
synonym: "up regulation of microtubule minus-end binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of microtubule minus-end binding" EXACT [GOC:TermGenie]
synonym: "upregulation of microtubule minus-end binding" EXACT [GOC:TermGenie]
is_a: GO:1902619 ! regulation of microtubule minus-end binding
is_a: GO:1904528 ! positive regulation of microtubule binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051011 ! microtubule minus-end binding
relationship: positively_regulates GO:0051011 ! microtubule minus-end binding
created_by: tb
creation_date: 2014-01-14T22:17:25Z

[Term]
id: GO:1902621
name: actomyosin contractile ring disassembly
namespace: biological_process
def: "The disaggregation of an actomyosin contractile ring into its constituent components." [GO_REF:0000079, GOC:TermGenie, PMID:14602073, PMID:22891673]
synonym: "actomyosin ring disassembly" RELATED [GOC:TermGenie]
synonym: "CAR disassembly" EXACT [GOC:TermGenie]
synonym: "constriction ring disassembly" RELATED [GOC:TermGenie]
synonym: "contractile actomyosin ring disassembly" EXACT [GOC:TermGenie]
synonym: "cytokinetic ring disassembly" RELATED [GOC:TermGenie]
is_a: GO:0022411 ! cellular component disassembly
is_a: GO:0032506 ! cytokinetic process
is_a: GO:0044837 ! actomyosin contractile ring organization
relationship: part_of GO:0061640 ! cytoskeleton-dependent cytokinesis
created_by: mah
creation_date: 2014-01-15T09:27:26Z

[Term]
id: GO:1902622
name: regulation of neutrophil migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neutrophil migration." [GO_REF:0000058, GOC:TermGenie, PMID:1826836]
is_a: GO:0002685 ! regulation of leukocyte migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990266 ! neutrophil migration
relationship: regulates GO:1990266 ! neutrophil migration
created_by: sl
creation_date: 2014-01-15T18:58:39Z

[Term]
id: GO:1902623
name: negative regulation of neutrophil migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of neutrophil migration." [GO_REF:0000058, GOC:TermGenie, PMID:1826836]
synonym: "down regulation of neutrophil migration" EXACT [GOC:TermGenie]
synonym: "down-regulation of neutrophil migration" EXACT [GOC:TermGenie]
synonym: "downregulation of neutrophil migration" EXACT [GOC:TermGenie]
synonym: "inhibition of neutrophil migration" NARROW [GOC:TermGenie]
is_a: GO:0002686 ! negative regulation of leukocyte migration
is_a: GO:1902622 ! regulation of neutrophil migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990266 ! neutrophil migration
relationship: negatively_regulates GO:1990266 ! neutrophil migration
created_by: sl
creation_date: 2014-01-15T18:58:49Z

[Term]
id: GO:1902624
name: positive regulation of neutrophil migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neutrophil migration." [GO_REF:0000058, GOC:TermGenie, PMID:1826836]
synonym: "activation of neutrophil migration" NARROW [GOC:TermGenie]
synonym: "up regulation of neutrophil migration" EXACT [GOC:TermGenie]
synonym: "up-regulation of neutrophil migration" EXACT [GOC:TermGenie]
synonym: "upregulation of neutrophil migration" EXACT [GOC:TermGenie]
is_a: GO:0002687 ! positive regulation of leukocyte migration
is_a: GO:1902622 ! regulation of neutrophil migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990266 ! neutrophil migration
relationship: positively_regulates GO:1990266 ! neutrophil migration
created_by: sl
creation_date: 2014-01-15T18:58:58Z

[Term]
id: GO:1902625
name: negative regulation of induction of conjugation with cellular fusion by negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A negative regulation of transcription from RNA polymerase II promoter that results in negative regulation of induction of conjugation with cellular fusion." [GO_REF:0000063, GOC:TermGenie, PMID:9671458]
is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
is_a: GO:0010515 ! negative regulation of induction of conjugation with cellular fusion
is_a: GO:1900406 ! regulation of conjugation with cellular fusion by regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
intersection_of: negatively_regulates GO:0010514 ! induction of conjugation with cellular fusion
relationship: negatively_regulates GO:0010514 ! induction of conjugation with cellular fusion
created_by: mah
creation_date: 2014-01-16T13:52:24Z

[Term]
id: GO:1902626
name: assembly of large subunit precursor of preribosome
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the large subunit precursor of the preribosome." [GO_REF:0000079, GOC:di, GOC:TermGenie, PMID:22735702]
synonym: "66S preribosome assembly" NARROW [GOC:TermGenie]
synonym: "66S preribosome formation" NARROW [GOC:TermGenie]
synonym: "preribosome, large subunit precursor formation" EXACT [GOC:TermGenie]
is_a: GO:0022618 ! ribonucleoprotein complex assembly
created_by: tb
creation_date: 2014-01-16T19:38:05Z

[Term]
id: GO:1902627
name: regulation of assembly of large subunit precursor of preribosome
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of assembly of a large subunit precursor of preribosome." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:22735702]
synonym: "regulation of 66S preribosome assembly" NARROW [GOC:TermGenie]
synonym: "regulation of 66S preribosome formation" NARROW [GOC:TermGenie]
synonym: "regulation of preribosome, large subunit precursor formation" EXACT [GOC:TermGenie]
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1902626 ! assembly of large subunit precursor of preribosome
relationship: regulates GO:1902626 ! assembly of large subunit precursor of preribosome
created_by: tb
creation_date: 2014-01-16T22:11:45Z

[Term]
id: GO:1902628
name: positive regulation of assembly of large subunit precursor of preribosome
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of assembly of a large subunit precursor of preribosome." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:22735702]
synonym: "activation of 66S preribosome assembly" NARROW [GOC:TermGenie]
synonym: "activation of 66S preribosome formation" NARROW [GOC:TermGenie]
synonym: "activation of assembly of large subunit precursor of preribosome" NARROW [GOC:TermGenie]
synonym: "activation of preribosome, large subunit precursor formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of 66S preribosome assembly" NARROW [GOC:TermGenie]
synonym: "positive regulation of 66S preribosome formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of preribosome, large subunit precursor formation" EXACT [GOC:TermGenie]
synonym: "up regulation of 66S preribosome assembly" NARROW [GOC:TermGenie]
synonym: "up regulation of 66S preribosome formation" NARROW [GOC:TermGenie]
synonym: "up regulation of assembly of large subunit precursor of preribosome" EXACT [GOC:TermGenie]
synonym: "up regulation of preribosome, large subunit precursor formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of 66S preribosome assembly" NARROW [GOC:TermGenie]
synonym: "up-regulation of 66S preribosome formation" NARROW [GOC:TermGenie]
synonym: "up-regulation of assembly of large subunit precursor of preribosome" EXACT [GOC:TermGenie]
synonym: "up-regulation of preribosome, large subunit precursor formation" EXACT [GOC:TermGenie]
synonym: "upregulation of 66S preribosome assembly" NARROW [GOC:TermGenie]
synonym: "upregulation of 66S preribosome formation" NARROW [GOC:TermGenie]
synonym: "upregulation of assembly of large subunit precursor of preribosome" EXACT [GOC:TermGenie]
synonym: "upregulation of preribosome, large subunit precursor formation" EXACT [GOC:TermGenie]
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1902627 ! regulation of assembly of large subunit precursor of preribosome
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1902626 ! assembly of large subunit precursor of preribosome
relationship: positively_regulates GO:1902626 ! assembly of large subunit precursor of preribosome
created_by: tb
creation_date: 2014-01-16T22:11:55Z

[Term]
id: GO:1902629
name: regulation of mRNA stability involved in cellular response to UV
namespace: biological_process
def: "Any regulation of mRNA stability that is involved in cellular response to UV." [GO_REF:0000060, GOC:TermGenie, PMID:10954610]
synonym: "regulation of mRNA stability involved in cellular response to ultraviolet light stimulus" EXACT [GOC:TermGenie]
synonym: "regulation of mRNA stability involved in cellular response to ultraviolet radiation stimulus" EXACT [GOC:TermGenie]
synonym: "regulation of mRNA stability involved in cellular response to UV light stimulus" EXACT [GOC:TermGenie]
synonym: "regulation of mRNA stability involved in cellular response to UV radiation stimulus" EXACT [GOC:TermGenie]
is_a: GO:0043488 ! regulation of mRNA stability
intersection_of: GO:0043488 ! regulation of mRNA stability
intersection_of: part_of GO:0034644 ! cellular response to UV
relationship: part_of GO:0034644 ! cellular response to UV
created_by: mah
creation_date: 2014-01-17T12:23:38Z

[Term]
id: GO:1902630
name: regulation of membrane hyperpolarization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of membrane hyperpolarization." [GO_REF:0000058, GOC:TermGenie, PMID:23223304]
is_a: GO:0042391 ! regulation of membrane potential
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060081 ! membrane hyperpolarization
relationship: regulates GO:0060081 ! membrane hyperpolarization
created_by: krc
creation_date: 2014-01-17T18:27:56Z

[Term]
id: GO:1902631
name: negative regulation of membrane hyperpolarization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of membrane hyperpolarization." [GO_REF:0000058, GOC:TermGenie, PMID:23223304]
synonym: "down regulation of membrane hyperpolarization" EXACT [GOC:TermGenie]
synonym: "down-regulation of membrane hyperpolarization" EXACT [GOC:TermGenie]
synonym: "downregulation of membrane hyperpolarization" EXACT [GOC:TermGenie]
synonym: "inhibition of membrane hyperpolarization" NARROW [GOC:TermGenie]
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:1902630 ! regulation of membrane hyperpolarization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060081 ! membrane hyperpolarization
relationship: negatively_regulates GO:0060081 ! membrane hyperpolarization
created_by: krc
creation_date: 2014-01-17T18:28:05Z

[Term]
id: GO:1902632
name: positive regulation of membrane hyperpolarization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of membrane hyperpolarization." [GO_REF:0000058, GOC:TermGenie, PMID:23223304]
synonym: "activation of membrane hyperpolarization" NARROW [GOC:TermGenie]
synonym: "up regulation of membrane hyperpolarization" EXACT [GOC:TermGenie]
synonym: "up-regulation of membrane hyperpolarization" EXACT [GOC:TermGenie]
synonym: "upregulation of membrane hyperpolarization" EXACT [GOC:TermGenie]
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:1902630 ! regulation of membrane hyperpolarization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060081 ! membrane hyperpolarization
relationship: positively_regulates GO:0060081 ! membrane hyperpolarization
created_by: krc
creation_date: 2014-01-17T18:28:14Z

[Term]
id: GO:1902633
name: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate." [GO_REF:0000068, GOC:di, GOC:TermGenie, PMID:22562153]
comment: Phosphatidylinositol-4,5-bisphosphate, PtdIns(4,5)P(2) common name.
synonym: "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolism" EXACT [GOC:TermGenie]
is_a: GO:0046488 ! phosphatidylinositol metabolic process
created_by: di
creation_date: 2014-01-18T00:34:27Z

[Term]
id: GO:1902634
name: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate." [GO_REF:0000068, GOC:di, GOC:TermGenie, PMID:22562153]
comment: Phosphatidylinositol-4,5-bisphosphate, PtdIns(4,5)P(2) common name.
synonym: "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown" EXACT [GOC:TermGenie]
synonym: "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism" EXACT [GOC:TermGenie]
synonym: "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation" EXACT [GOC:TermGenie]
is_a: GO:0031161 ! phosphatidylinositol catabolic process
is_a: GO:1902633 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process
created_by: di
creation_date: 2014-01-18T00:34:36Z

[Term]
id: GO:1902635
name: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate." [GO_REF:0000068, GOC:di, GOC:TermGenie, PMID:22562153]
comment: Phosphatidylinositol-4,5-bisphosphate, PtdIns(4,5)P(2) common name.
synonym: "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism" EXACT [GOC:TermGenie]
synonym: "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis" EXACT [GOC:TermGenie]
synonym: "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation" EXACT [GOC:TermGenie]
synonym: "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis" EXACT [GOC:TermGenie]
is_a: GO:0006661 ! phosphatidylinositol biosynthetic process
is_a: GO:1902633 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process
created_by: di
creation_date: 2014-01-18T00:34:45Z

[Term]
id: GO:1902636
name: kinociliary basal body
namespace: cellular_component
def: "A ciliary basal body that is part of a kinocilium." [GO_REF:0000064, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:15855039, PMID:15882574]
synonym: "cilial basal body of kinocilium" EXACT [GOC:TermGenie]
synonym: "ciliary basal body of kinocilium" EXACT [GOC:TermGenie]
synonym: "cilium basal body of kinocilium" EXACT [GOC:TermGenie]
synonym: "kinocilial basal body" EXACT []
synonym: "kinocilium basal body" EXACT []
synonym: "kinocilium ciliary basal body" EXACT []
synonym: "microtubule basal body of kinocilium" EXACT [GOC:TermGenie]
is_a: GO:0036064 ! ciliary basal body
is_a: GO:0097458 ! neuron part
intersection_of: GO:0036064 ! ciliary basal body
intersection_of: part_of GO:0060091 ! kinocilium
relationship: part_of GO:0060091 ! kinocilium
created_by: pr
creation_date: 2014-01-20T13:48:45Z

[Term]
id: GO:1902637
name: neural crest cell differentiation involved in thymus development
namespace: biological_process
def: "Any neural crest cell differentiation that is involved in thymus development." [GO_REF:0000060, GOC:nhn, GOC:TermGenie, PMID:15741317, PMID:18292542]
is_a: GO:0014033 ! neural crest cell differentiation
intersection_of: GO:0014033 ! neural crest cell differentiation
intersection_of: part_of GO:0048538 ! thymus development
relationship: part_of GO:0048538 ! thymus development
created_by: pr
creation_date: 2014-01-21T10:03:20Z

[Term]
id: GO:1902638
name: neural crest cell differentiation involved in parathyroid gland development
namespace: biological_process
def: "Any neural crest cell differentiation that is involved in parathyroid gland development." [GO_REF:0000060, GOC:nhn, GOC:TermGenie, PMID:15741317]
is_a: GO:0014033 ! neural crest cell differentiation
intersection_of: GO:0014033 ! neural crest cell differentiation
intersection_of: part_of GO:0060017 ! parathyroid gland development
relationship: part_of GO:0060017 ! parathyroid gland development
created_by: pr
creation_date: 2014-01-21T10:03:29Z

[Term]
id: GO:1902639
name: propan-2-ol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving propan-2-ol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:16346237]
synonym: "Isopropanol metabolic process" EXACT []
synonym: "Isopropyl alcohol metabolic process" EXACT []
synonym: "propan-2-ol metabolism" EXACT [GOC:TermGenie]
is_a: GO:1902652 ! secondary alcohol metabolic process
created_by: tt
creation_date: 2014-01-21T13:57:13Z

[Term]
id: GO:1902640
name: propan-2-ol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of propan-2-ol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:16346237]
synonym: "Isopropanol biosynthetic process" EXACT []
synonym: "Isopropyl alcohol biosynthetic process" EXACT []
synonym: "propan-2-ol anabolism" EXACT [GOC:TermGenie]
synonym: "propan-2-ol biosynthesis" EXACT [GOC:TermGenie]
synonym: "propan-2-ol formation" EXACT [GOC:TermGenie]
synonym: "propan-2-ol synthesis" EXACT [GOC:TermGenie]
is_a: GO:1902639 ! propan-2-ol metabolic process
is_a: GO:1902653 ! secondary alcohol biosynthetic process
created_by: tt
creation_date: 2014-01-21T13:57:22Z

[Term]
id: GO:1902641
name: regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:22562153]
synonym: "regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation" EXACT [GOC:TermGenie]
is_a: GO:0060696 ! regulation of phospholipid catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1902634 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process
relationship: regulates GO:1902634 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process
created_by: di
creation_date: 2014-01-21T17:54:14Z

[Term]
id: GO:1902642
name: negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:22562153]
synonym: "down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation" EXACT [GOC:TermGenie]
synonym: "inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown" NARROW [GOC:TermGenie]
synonym: "inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation" NARROW [GOC:TermGenie]
synonym: "negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation" EXACT [GOC:TermGenie]
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:0050995 ! negative regulation of lipid catabolic process
is_a: GO:1902641 ! regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process
is_a: GO:1903726 ! negative regulation of phospholipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1902634 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process
relationship: negatively_regulates GO:1902634 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process
created_by: di
creation_date: 2014-01-21T17:54:23Z

[Term]
id: GO:1902643
name: positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:22562153]
synonym: "activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown" NARROW [GOC:TermGenie]
synonym: "activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism" NARROW [GOC:TermGenie]
synonym: "activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation" NARROW [GOC:TermGenie]
synonym: "positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation" EXACT [GOC:TermGenie]
is_a: GO:0060697 ! positive regulation of phospholipid catabolic process
is_a: GO:1902641 ! regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1902634 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process
relationship: positively_regulates GO:1902634 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process
created_by: di
creation_date: 2014-01-21T17:54:32Z

[Term]
id: GO:1902644
name: tertiary alcohol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tertiary alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:11288200]
synonym: "tertiary alcohol metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006066 ! alcohol metabolic process
created_by: tt
creation_date: 2014-01-21T17:53:53Z

[Term]
id: GO:1902645
name: tertiary alcohol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tertiary alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:11288200]
synonym: "tertiary alcohol anabolism" EXACT [GOC:TermGenie]
synonym: "tertiary alcohol biosynthesis" EXACT [GOC:TermGenie]
synonym: "tertiary alcohol formation" EXACT [GOC:TermGenie]
synonym: "tertiary alcohol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046165 ! alcohol biosynthetic process
is_a: GO:1902644 ! tertiary alcohol metabolic process
created_by: tt
creation_date: 2014-01-21T17:54:02Z

[Term]
id: GO:1902646
name: regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:22562153]
synonym: "regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation" EXACT [GOC:TermGenie]
synonym: "regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010511 ! regulation of phosphatidylinositol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1902635 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process
relationship: regulates GO:1902635 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process
created_by: di
creation_date: 2014-01-21T17:57:57Z

[Term]
id: GO:1902647
name: negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:22562153]
synonym: "down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation" EXACT [GOC:TermGenie]
synonym: "down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation" EXACT [GOC:TermGenie]
synonym: "downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation" NARROW [GOC:TermGenie]
synonym: "inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010512 ! negative regulation of phosphatidylinositol biosynthetic process
is_a: GO:1902646 ! regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1902635 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process
relationship: negatively_regulates GO:1902635 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process
created_by: di
creation_date: 2014-01-21T17:58:06Z

[Term]
id: GO:1902648
name: positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:22562153]
synonym: "activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism" NARROW [GOC:TermGenie]
synonym: "activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation" NARROW [GOC:TermGenie]
synonym: "activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation" EXACT [GOC:TermGenie]
synonym: "up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation" EXACT [GOC:TermGenie]
synonym: "upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010513 ! positive regulation of phosphatidylinositol biosynthetic process
is_a: GO:1902646 ! regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1902635 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process
relationship: positively_regulates GO:1902635 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process
created_by: di
creation_date: 2014-01-21T17:58:15Z

[Term]
id: GO:1902649
name: regulation of histone H2A-H2B dimer displacement
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of histone H2A-H2B dimer displacement." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:22199252]
is_a: GO:1902275 ! regulation of chromatin organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001208 ! histone H2A-H2B dimer displacement
relationship: regulates GO:0001208 ! histone H2A-H2B dimer displacement
created_by: di
creation_date: 2014-01-21T18:19:04Z

[Term]
id: GO:1902650
name: negative regulation of histone H2A-H2B dimer displacement
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone H2A-H2B dimer displacement." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:22199252]
synonym: "down regulation of histone H2A-H2B dimer displacement" EXACT [GOC:TermGenie]
synonym: "down-regulation of histone H2A-H2B dimer displacement" EXACT [GOC:TermGenie]
synonym: "downregulation of histone H2A-H2B dimer displacement" EXACT [GOC:TermGenie]
synonym: "inhibition of histone H2A-H2B dimer displacement" NARROW [GOC:TermGenie]
is_a: GO:1902649 ! regulation of histone H2A-H2B dimer displacement
is_a: GO:2001251 ! negative regulation of chromosome organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001208 ! histone H2A-H2B dimer displacement
relationship: negatively_regulates GO:0001208 ! histone H2A-H2B dimer displacement
created_by: di
creation_date: 2014-01-21T18:19:14Z

[Term]
id: GO:1902651
name: positive regulation of histone H2A-H2B dimer displacement
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of histone H2A-H2B dimer displacement." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:22199252]
synonym: "activation of histone H2A-H2B dimer displacement" NARROW [GOC:TermGenie]
synonym: "up regulation of histone H2A-H2B dimer displacement" EXACT [GOC:TermGenie]
synonym: "up-regulation of histone H2A-H2B dimer displacement" EXACT [GOC:TermGenie]
synonym: "upregulation of histone H2A-H2B dimer displacement" EXACT [GOC:TermGenie]
is_a: GO:1902649 ! regulation of histone H2A-H2B dimer displacement
is_a: GO:2001252 ! positive regulation of chromosome organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001208 ! histone H2A-H2B dimer displacement
relationship: positively_regulates GO:0001208 ! histone H2A-H2B dimer displacement
created_by: di
creation_date: 2014-01-21T18:19:23Z

[Term]
id: GO:1902652
name: secondary alcohol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving secondary alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:11288200]
synonym: "secondary alcohol metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006066 ! alcohol metabolic process
created_by: tt
creation_date: 2014-01-22T10:14:52Z

[Term]
id: GO:1902653
name: secondary alcohol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of secondary alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:11288200]
synonym: "secondary alcohol anabolism" EXACT [GOC:TermGenie]
synonym: "secondary alcohol biosynthesis" EXACT [GOC:TermGenie]
synonym: "secondary alcohol formation" EXACT [GOC:TermGenie]
synonym: "secondary alcohol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046165 ! alcohol biosynthetic process
is_a: GO:1902652 ! secondary alcohol metabolic process
created_by: tt
creation_date: 2014-01-22T10:15:02Z

[Term]
id: GO:1902654
name: aromatic primary alcohol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aromatic primary alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:19219878]
synonym: "aromatic primary alcohol metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0034308 ! primary alcohol metabolic process
is_a: GO:0044763 ! single-organism cellular process
is_a: GO:1901360 ! organic cyclic compound metabolic process
created_by: tt
creation_date: 2014-01-22T10:47:21Z

[Term]
id: GO:1902655
name: aromatic primary alcohol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of aromatic primary alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:19219878]
synonym: "aromatic primary alcohol anabolism" EXACT [GOC:TermGenie]
synonym: "aromatic primary alcohol biosynthesis" EXACT [GOC:TermGenie]
synonym: "aromatic primary alcohol formation" EXACT [GOC:TermGenie]
synonym: "aromatic primary alcohol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0034309 ! primary alcohol biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1902654 ! aromatic primary alcohol metabolic process
created_by: tt
creation_date: 2014-01-22T10:47:30Z

[Term]
id: GO:1902656
name: calcium ion import into cytosol
namespace: biological_process
def: "The directed movement of calcium ion into a cytosol." [GO_REF:0000075, GOC:TermGenie, GOC:vw]
synonym: "calcium import into cytosol" BROAD []
is_a: GO:0060402 ! calcium ion transport into cytosol
is_a: GO:0070509 ! calcium ion import
created_by: pr
creation_date: 2014-01-22T13:41:11Z

[Term]
id: GO:1902657
name: protein localization to prospore membrane
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a prospore membrane." [GO_REF:0000087, GOC:dph, GOC:TermGenie, PMID:24036347]
synonym: "protein localisation in prospore membrane" EXACT [GOC:TermGenie]
synonym: "protein localisation to prospore membrane" EXACT [GOC:TermGenie]
synonym: "protein localization in prospore membrane" EXACT [GOC:TermGenie]
is_a: GO:0072657 ! protein localization to membrane
created_by: dph
creation_date: 2014-01-28T15:11:13Z

[Term]
id: GO:1902658
name: establishment of protein localization to prospore membrane
namespace: biological_process
def: "The directed movement of a protein to a specific location in a prospore membrane." [GO_REF:0000087, GOC:dph, GOC:TermGenie, PMID:24036347]
synonym: "establishment of protein localisation in prospore membrane" EXACT [GOC:TermGenie]
synonym: "establishment of protein localisation to prospore membrane" EXACT [GOC:TermGenie]
synonym: "establishment of protein localization in prospore membrane" EXACT [GOC:TermGenie]
is_a: GO:0090150 ! establishment of protein localization to membrane
relationship: part_of GO:1902657 ! protein localization to prospore membrane
created_by: dph
creation_date: 2014-01-28T15:11:22Z

[Term]
id: GO:1902659
name: regulation of glucose mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glucose mediated signaling pathway." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:24277933]
synonym: "regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0032844 ! regulation of homeostatic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010255 ! glucose mediated signaling pathway
relationship: regulates GO:0010255 ! glucose mediated signaling pathway
created_by: di
creation_date: 2014-01-28T17:54:21Z

[Term]
id: GO:1902660
name: negative regulation of glucose mediated signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glucose mediated signaling pathway." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:24277933]
synonym: "down regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "down-regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "downregulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "inhibition of glucose mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of glucose mediated signalling" NARROW [GOC:TermGenie]
synonym: "negative regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0032845 ! negative regulation of homeostatic process
is_a: GO:1902659 ! regulation of glucose mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010255 ! glucose mediated signaling pathway
relationship: negatively_regulates GO:0010255 ! glucose mediated signaling pathway
created_by: di
creation_date: 2014-01-28T17:54:31Z

[Term]
id: GO:1902661
name: positive regulation of glucose mediated signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glucose mediated signaling pathway." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:24277933]
synonym: "activation of glucose mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of glucose mediated signalling" NARROW [GOC:TermGenie]
synonym: "positive regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "up regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "up-regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "upregulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of glucose mediated signalling" EXACT [GOC:TermGenie]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0032846 ! positive regulation of homeostatic process
is_a: GO:1902659 ! regulation of glucose mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010255 ! glucose mediated signaling pathway
relationship: positively_regulates GO:0010255 ! glucose mediated signaling pathway
created_by: di
creation_date: 2014-01-28T17:54:47Z

[Term]
id: GO:1902662
name: regulation of peptidyl-L-cysteine S-palmitoylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of peptidyl-L-cysteine S-palmitoylation." [GO_REF:0000058, GOC:TermGenie, PMID:23444136]
synonym: "regulation of peptidyl-cysteine S-palmitoylation" EXACT [GOC:TermGenie]
synonym: "regulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "regulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "regulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "regulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [GOC:TermGenie]
is_a: GO:1903059 ! regulation of protein lipidation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0018230 ! peptidyl-L-cysteine S-palmitoylation
relationship: regulates GO:0018230 ! peptidyl-L-cysteine S-palmitoylation
created_by: mm2
creation_date: 2014-01-29T11:33:09Z

[Term]
id: GO:1902663
name: negative regulation of peptidyl-L-cysteine S-palmitoylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-L-cysteine S-palmitoylation." [GO_REF:0000058, GOC:TermGenie, PMID:23444136]
synonym: "down regulation of peptidyl-cysteine S-palmitoylation" EXACT [GOC:TermGenie]
synonym: "down regulation of peptidyl-L-cysteine S-palmitoylation" EXACT [GOC:TermGenie]
synonym: "down regulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "down regulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "down regulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "down regulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "down-regulation of peptidyl-cysteine S-palmitoylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of peptidyl-L-cysteine S-palmitoylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "down-regulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "down-regulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "down-regulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "downregulation of peptidyl-cysteine S-palmitoylation" EXACT [GOC:TermGenie]
synonym: "downregulation of peptidyl-L-cysteine S-palmitoylation" EXACT [GOC:TermGenie]
synonym: "downregulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "downregulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "downregulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "downregulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "inhibition of peptidyl-cysteine S-palmitoylation" NARROW [GOC:TermGenie]
synonym: "inhibition of peptidyl-L-cysteine S-palmitoylation" NARROW [GOC:TermGenie]
synonym: "inhibition of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine" NARROW [GOC:TermGenie]
synonym: "inhibition of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine" NARROW [GOC:TermGenie]
synonym: "inhibition of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine" NARROW [GOC:TermGenie]
synonym: "inhibition of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine" NARROW [GOC:TermGenie]
synonym: "negative regulation of peptidyl-cysteine S-palmitoylation" EXACT [GOC:TermGenie]
synonym: "negative regulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "negative regulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "negative regulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "negative regulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [GOC:TermGenie]
is_a: GO:1902662 ! regulation of peptidyl-L-cysteine S-palmitoylation
is_a: GO:1903060 ! negative regulation of protein lipidation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0018230 ! peptidyl-L-cysteine S-palmitoylation
relationship: negatively_regulates GO:0018230 ! peptidyl-L-cysteine S-palmitoylation
created_by: mm2
creation_date: 2014-01-29T11:33:19Z

[Term]
id: GO:1902664
name: positive regulation of peptidyl-L-cysteine S-palmitoylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of peptidyl-L-cysteine S-palmitoylation." [GO_REF:0000058, GOC:TermGenie, PMID:23444136]
synonym: "activation of peptidyl-cysteine S-palmitoylation" NARROW [GOC:TermGenie]
synonym: "activation of peptidyl-L-cysteine S-palmitoylation" NARROW [GOC:TermGenie]
synonym: "activation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine" NARROW [GOC:TermGenie]
synonym: "activation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine" NARROW [GOC:TermGenie]
synonym: "activation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine" NARROW [GOC:TermGenie]
synonym: "activation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine" NARROW [GOC:TermGenie]
synonym: "positive regulation of peptidyl-cysteine S-palmitoylation" EXACT [GOC:TermGenie]
synonym: "positive regulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "positive regulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "positive regulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "positive regulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "up regulation of peptidyl-cysteine S-palmitoylation" EXACT [GOC:TermGenie]
synonym: "up regulation of peptidyl-L-cysteine S-palmitoylation" EXACT [GOC:TermGenie]
synonym: "up regulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "up regulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "up regulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "up regulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "up-regulation of peptidyl-cysteine S-palmitoylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of peptidyl-L-cysteine S-palmitoylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "up-regulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "up-regulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "up-regulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "upregulation of peptidyl-cysteine S-palmitoylation" EXACT [GOC:TermGenie]
synonym: "upregulation of peptidyl-L-cysteine S-palmitoylation" EXACT [GOC:TermGenie]
synonym: "upregulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "upregulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "upregulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine" EXACT [GOC:TermGenie]
synonym: "upregulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [GOC:TermGenie]
is_a: GO:1902662 ! regulation of peptidyl-L-cysteine S-palmitoylation
is_a: GO:1903061 ! positive regulation of protein lipidation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0018230 ! peptidyl-L-cysteine S-palmitoylation
relationship: positively_regulates GO:0018230 ! peptidyl-L-cysteine S-palmitoylation
created_by: mm2
creation_date: 2014-01-29T11:33:28Z

[Term]
id: GO:1902665
name: response to isobutanol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isobutanol stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:24014527]
synonym: "response to 2-methylpropan-1-ol" EXACT [GOC:mengo_curators]
is_a: GO:0097305 ! response to alcohol
created_by: tt
creation_date: 2014-01-29T14:06:58Z

[Term]
id: GO:1902666
name: protein localization to Mmi1 nuclear focus complex
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a Mmi1 nuclear focus complex." [GO_REF:0000087, GOC:TermGenie, PMID:23980030]
synonym: "protein localisation in Mmi1 nuclear focus complex" EXACT [GOC:TermGenie]
synonym: "protein localisation to Mmi1 nuclear focus complex" EXACT [GOC:TermGenie]
synonym: "protein localization in Mmi1 nuclear focus complex" EXACT [GOC:TermGenie]
is_a: GO:0034504 ! protein localization to nucleus
created_by: mah
creation_date: 2014-01-30T10:42:17Z

[Term]
id: GO:1902667
name: regulation of axon guidance
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of axon guidance." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:23006775]
synonym: "regulation of axon chemotaxis" RELATED [GOC:TermGenie]
synonym: "regulation of axon growth cone guidance" NARROW [GOC:TermGenie]
synonym: "regulation of axon pathfinding" EXACT [GOC:TermGenie]
is_a: GO:0050770 ! regulation of axonogenesis
is_a: GO:0050920 ! regulation of chemotaxis
is_a: GO:0051270 ! regulation of cellular component movement
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007411 ! axon guidance
relationship: regulates GO:0007411 ! axon guidance
created_by: hjd
creation_date: 2014-01-31T18:50:10Z

[Term]
id: GO:1902668
name: negative regulation of axon guidance
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of axon guidance." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:23006775]
synonym: "down regulation of axon chemotaxis" RELATED [GOC:TermGenie]
synonym: "down regulation of axon growth cone guidance" NARROW [GOC:TermGenie]
synonym: "down regulation of axon guidance" EXACT [GOC:TermGenie]
synonym: "down regulation of axon pathfinding" EXACT [GOC:TermGenie]
synonym: "down-regulation of axon chemotaxis" RELATED [GOC:TermGenie]
synonym: "down-regulation of axon growth cone guidance" NARROW [GOC:TermGenie]
synonym: "down-regulation of axon guidance" EXACT [GOC:TermGenie]
synonym: "down-regulation of axon pathfinding" EXACT [GOC:TermGenie]
synonym: "downregulation of axon chemotaxis" RELATED [GOC:TermGenie]
synonym: "downregulation of axon growth cone guidance" NARROW [GOC:TermGenie]
synonym: "downregulation of axon guidance" EXACT [GOC:TermGenie]
synonym: "downregulation of axon pathfinding" EXACT [GOC:TermGenie]
synonym: "inhibition of axon chemotaxis" RELATED [GOC:TermGenie]
synonym: "inhibition of axon growth cone guidance" NARROW [GOC:TermGenie]
synonym: "inhibition of axon guidance" NARROW [GOC:TermGenie]
synonym: "inhibition of axon pathfinding" NARROW [GOC:TermGenie]
synonym: "negative regulation of axon chemotaxis" RELATED [GOC:TermGenie]
synonym: "negative regulation of axon growth cone guidance" NARROW [GOC:TermGenie]
synonym: "negative regulation of axon pathfinding" EXACT [GOC:TermGenie]
is_a: GO:0050771 ! negative regulation of axonogenesis
is_a: GO:0050922 ! negative regulation of chemotaxis
is_a: GO:0051271 ! negative regulation of cellular component movement
is_a: GO:1902667 ! regulation of axon guidance
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007411 ! axon guidance
relationship: negatively_regulates GO:0007411 ! axon guidance
created_by: hjd
creation_date: 2014-01-31T18:50:19Z

[Term]
id: GO:1902669
name: positive regulation of axon guidance
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of axon guidance." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:23006775]
synonym: "activation of axon chemotaxis" RELATED [GOC:TermGenie]
synonym: "activation of axon growth cone guidance" NARROW [GOC:TermGenie]
synonym: "activation of axon guidance" NARROW [GOC:TermGenie]
synonym: "activation of axon pathfinding" NARROW [GOC:TermGenie]
synonym: "positive regulation of axon chemotaxis" RELATED [GOC:TermGenie]
synonym: "positive regulation of axon growth cone guidance" NARROW [GOC:TermGenie]
synonym: "positive regulation of axon pathfinding" EXACT [GOC:TermGenie]
synonym: "up regulation of axon chemotaxis" RELATED [GOC:TermGenie]
synonym: "up regulation of axon growth cone guidance" NARROW [GOC:TermGenie]
synonym: "up regulation of axon guidance" EXACT [GOC:TermGenie]
synonym: "up regulation of axon pathfinding" EXACT [GOC:TermGenie]
synonym: "up-regulation of axon chemotaxis" RELATED [GOC:TermGenie]
synonym: "up-regulation of axon growth cone guidance" NARROW [GOC:TermGenie]
synonym: "up-regulation of axon guidance" EXACT [GOC:TermGenie]
synonym: "up-regulation of axon pathfinding" EXACT [GOC:TermGenie]
synonym: "upregulation of axon chemotaxis" RELATED [GOC:TermGenie]
synonym: "upregulation of axon growth cone guidance" NARROW [GOC:TermGenie]
synonym: "upregulation of axon guidance" EXACT [GOC:TermGenie]
synonym: "upregulation of axon pathfinding" EXACT [GOC:TermGenie]
is_a: GO:0050772 ! positive regulation of axonogenesis
is_a: GO:0050921 ! positive regulation of chemotaxis
is_a: GO:0051272 ! positive regulation of cellular component movement
is_a: GO:1902667 ! regulation of axon guidance
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007411 ! axon guidance
relationship: positively_regulates GO:0007411 ! axon guidance
created_by: hjd
creation_date: 2014-01-31T18:50:29Z

[Term]
id: GO:1902670
name: carbon dioxide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with carbon dioxide." [GO_REF:0000067, GOC:bhm, GOC:TermGenie, PMID:15491402]
synonym: "CO2 binding" EXACT []
is_a: GO:0005488 ! binding
created_by: bhm
creation_date: 2014-02-04T10:38:41Z

[Term]
id: GO:1902671
name: left anterior basal body
namespace: cellular_component
def: "Any ciliary basal body that is part of a left anterior flagellum found in Giardia species (trophozoite stage)." [GO_REF:0000064, GOC:giardia, GOC:TermGenie, ISBN:9780124260207, PMID:16607022, PMID:5961344]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
synonym: "cilial basal body of left anterior cilium" EXACT [GOC:TermGenie]
synonym: "cilial basal body of left anterior flagellum" EXACT [GOC:TermGenie]
synonym: "ciliary basal body of left anterior cilium" EXACT [GOC:TermGenie]
synonym: "ciliary basal body of left anterior flagellum" EXACT [GOC:TermGenie]
synonym: "cilium basal body of left anterior cilium" EXACT [GOC:TermGenie]
synonym: "cilium basal body of left anterior flagellum" EXACT [GOC:TermGenie]
synonym: "left anterior flagellum ciliary basal body" EXACT []
synonym: "microtubule basal body of left anterior cilium" EXACT [GOC:TermGenie]
synonym: "microtubule basal body of left anterior flagellum" EXACT [GOC:TermGenie]
is_a: GO:0036064 ! ciliary basal body
intersection_of: GO:0036064 ! ciliary basal body
intersection_of: part_of GO:0097554 ! left anterior flagellum
relationship: part_of GO:0097554 ! left anterior flagellum
created_by: pr
creation_date: 2014-02-05T14:28:44Z

[Term]
id: GO:1902672
name: right anterior basal body
namespace: cellular_component
def: "Any ciliary basal body that is part of a right anterior flagellum found in Giardia species (trophozoite stage)." [GO_REF:0000064, GOC:giardia, GOC:TermGenie, ISBN:9780124260207, PMID:16607022, PMID:5961344]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
synonym: "cilial basal body of right anterior cilium" EXACT [GOC:TermGenie]
synonym: "cilial basal body of right anterior flagellum" EXACT [GOC:TermGenie]
synonym: "ciliary basal body of right anterior cilium" EXACT [GOC:TermGenie]
synonym: "ciliary basal body of right anterior flagellum" EXACT [GOC:TermGenie]
synonym: "cilium basal body of right anterior cilium" EXACT [GOC:TermGenie]
synonym: "cilium basal body of right anterior flagellum" EXACT [GOC:TermGenie]
synonym: "microtubule basal body of right anterior cilium" EXACT [GOC:TermGenie]
synonym: "microtubule basal body of right anterior flagellum" EXACT [GOC:TermGenie]
synonym: "right anterior flagellum ciliary basal body" EXACT []
is_a: GO:0036064 ! ciliary basal body
intersection_of: GO:0036064 ! ciliary basal body
intersection_of: part_of GO:0097555 ! right anterior flagellum
relationship: part_of GO:0097555 ! right anterior flagellum
created_by: pr
creation_date: 2014-02-05T14:46:26Z

[Term]
id: GO:1902673
name: left posteriolateral basal body
namespace: cellular_component
def: "Any ciliary basal body that is part of a left posteriolateral flagellum found in Giardia species (trophozoite stage)." [GO_REF:0000064, GOC:giardia, GOC:TermGenie, ISBN:9780124260207, PMID:16607022, PMID:5961344]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
synonym: "cilial basal body of left posteriolateral cilium" EXACT [GOC:TermGenie]
synonym: "cilial basal body of left posteriolateral flagellum" EXACT [GOC:TermGenie]
synonym: "cilial basal body of left posterolateral cilium" EXACT [GOC:TermGenie]
synonym: "cilial basal body of left posterolateral flagellum" EXACT [GOC:TermGenie]
synonym: "ciliary basal body of left posteriolateral cilium" EXACT [GOC:TermGenie]
synonym: "ciliary basal body of left posteriolateral flagellum" EXACT [GOC:TermGenie]
synonym: "ciliary basal body of left posterolateral cilium" EXACT [GOC:TermGenie]
synonym: "ciliary basal body of left posterolateral flagellum" EXACT [GOC:TermGenie]
synonym: "cilium basal body of left posteriolateral cilium" EXACT [GOC:TermGenie]
synonym: "cilium basal body of left posteriolateral flagellum" EXACT [GOC:TermGenie]
synonym: "cilium basal body of left posterolateral cilium" EXACT [GOC:TermGenie]
synonym: "cilium basal body of left posterolateral flagellum" EXACT [GOC:TermGenie]
synonym: "left posteriolateral flagellum ciliary basal body" EXACT []
synonym: "microtubule basal body of left posteriolateral cilium" EXACT [GOC:TermGenie]
synonym: "microtubule basal body of left posteriolateral flagellum" EXACT [GOC:TermGenie]
synonym: "microtubule basal body of left posterolateral cilium" EXACT [GOC:TermGenie]
synonym: "microtubule basal body of left posterolateral flagellum" EXACT [GOC:TermGenie]
is_a: GO:0036064 ! ciliary basal body
intersection_of: GO:0036064 ! ciliary basal body
intersection_of: part_of GO:0097556 ! left posteriolateral flagellum
relationship: part_of GO:0097556 ! left posteriolateral flagellum
created_by: pr
creation_date: 2014-02-05T14:49:25Z

[Term]
id: GO:1902674
name: right posteriolateral basal body
namespace: cellular_component
def: "Any ciliary basal body that is part of a right posteriolateral flagellum found in Giardia species (trophozoite stage)." [GO_REF:0000064, GOC:giardia, GOC:TermGenie, ISBN:9780124260207, PMID:16607022, PMID:5961344]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
synonym: "cilial basal body of right posteriolateral cilium" EXACT [GOC:TermGenie]
synonym: "cilial basal body of right posteriolateral flagellum" EXACT [GOC:TermGenie]
synonym: "cilial basal body of right posterolateral cilium" EXACT [GOC:TermGenie]
synonym: "cilial basal body of right posterolateral flagellum" EXACT [GOC:TermGenie]
synonym: "ciliary basal body of right posteriolateral cilium" EXACT [GOC:TermGenie]
synonym: "ciliary basal body of right posteriolateral flagellum" EXACT [GOC:TermGenie]
synonym: "ciliary basal body of right posterolateral cilium" EXACT [GOC:TermGenie]
synonym: "ciliary basal body of right posterolateral flagellum" EXACT [GOC:TermGenie]
synonym: "cilium basal body of right posteriolateral cilium" EXACT [GOC:TermGenie]
synonym: "cilium basal body of right posteriolateral flagellum" EXACT [GOC:TermGenie]
synonym: "cilium basal body of right posterolateral cilium" EXACT [GOC:TermGenie]
synonym: "cilium basal body of right posterolateral flagellum" EXACT [GOC:TermGenie]
synonym: "microtubule basal body of right posteriolateral cilium" EXACT [GOC:TermGenie]
synonym: "microtubule basal body of right posteriolateral flagellum" EXACT [GOC:TermGenie]
synonym: "microtubule basal body of right posterolateral cilium" EXACT [GOC:TermGenie]
synonym: "microtubule basal body of right posterolateral flagellum" EXACT [GOC:TermGenie]
synonym: "right posteriolateral flagellum ciliary basal body" EXACT []
is_a: GO:0036064 ! ciliary basal body
intersection_of: GO:0036064 ! ciliary basal body
intersection_of: part_of GO:0097557 ! right posteriolateral flagellum
relationship: part_of GO:0097557 ! right posteriolateral flagellum
created_by: pr
creation_date: 2014-02-05T14:52:04Z

[Term]
id: GO:1902675
name: left ventral basal body
namespace: cellular_component
def: "Any ciliary basal body that is part of a left ventral flagellum found in Giardia species (trophozoite stage)." [GO_REF:0000064, GOC:giardia, GOC:TermGenie, ISBN:9780124260207, PMID:16607022, PMID:5961344]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
synonym: "cilial basal body of left ventral cilium" EXACT [GOC:TermGenie]
synonym: "cilial basal body of left ventral flagellum" EXACT [GOC:TermGenie]
synonym: "ciliary basal body of left ventral cilium" EXACT [GOC:TermGenie]
synonym: "ciliary basal body of left ventral flagellum" EXACT [GOC:TermGenie]
synonym: "cilium basal body of left ventral cilium" EXACT [GOC:TermGenie]
synonym: "cilium basal body of left ventral flagellum" EXACT [GOC:TermGenie]
synonym: "left ventral flagellum ciliary basal body" EXACT []
synonym: "microtubule basal body of left ventral cilium" EXACT [GOC:TermGenie]
synonym: "microtubule basal body of left ventral flagellum" EXACT [GOC:TermGenie]
is_a: GO:0036064 ! ciliary basal body
intersection_of: GO:0036064 ! ciliary basal body
intersection_of: part_of GO:0097558 ! left ventral flagellum
relationship: part_of GO:0097558 ! left ventral flagellum
created_by: pr
creation_date: 2014-02-05T14:54:54Z

[Term]
id: GO:1902676
name: right ventral basal body
namespace: cellular_component
def: "Any ciliary basal body that is part of a right ventral flagellum found in Giardia species (trophozoite stage)." [GO_REF:0000064, GOC:giardia, GOC:TermGenie, ISBN:9780124260207, PMID:16607022, PMID:5961344]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
synonym: "cilial basal body of right ventral cilium" EXACT [GOC:TermGenie]
synonym: "cilial basal body of right ventral flagellum" EXACT [GOC:TermGenie]
synonym: "ciliary basal body of right ventral cilium" EXACT [GOC:TermGenie]
synonym: "ciliary basal body of right ventral flagellum" EXACT [GOC:TermGenie]
synonym: "cilium basal body of right ventral cilium" EXACT [GOC:TermGenie]
synonym: "cilium basal body of right ventral flagellum" EXACT [GOC:TermGenie]
synonym: "microtubule basal body of right ventral cilium" EXACT [GOC:TermGenie]
synonym: "microtubule basal body of right ventral flagellum" EXACT [GOC:TermGenie]
synonym: "right ventral flagellum ciliary basal body" EXACT []
is_a: GO:0036064 ! ciliary basal body
intersection_of: GO:0036064 ! ciliary basal body
intersection_of: part_of GO:0097559 ! right ventral flagellum
relationship: part_of GO:0097559 ! right ventral flagellum
created_by: pr
creation_date: 2014-02-05T14:58:13Z

[Term]
id: GO:1902677
name: left caudal basal body
namespace: cellular_component
def: "Any ciliary basal body that is part of a left caudal flagellum found in Giardia species (trophozoite stage)." [GO_REF:0000064, GOC:giardia, GOC:TermGenie, ISBN:9780124260207, PMID:16607022, PMID:5961344]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
synonym: "cilial basal body of left caudal cilium" EXACT [GOC:TermGenie]
synonym: "cilial basal body of left caudal flagellum" EXACT [GOC:TermGenie]
synonym: "ciliary basal body of left caudal cilium" EXACT [GOC:TermGenie]
synonym: "ciliary basal body of left caudal flagellum" EXACT [GOC:TermGenie]
synonym: "cilium basal body of left caudal cilium" EXACT [GOC:TermGenie]
synonym: "cilium basal body of left caudal flagellum" EXACT [GOC:TermGenie]
synonym: "left caudal flagellum ciliary basal body" EXACT []
synonym: "microtubule basal body of left caudal cilium" EXACT [GOC:TermGenie]
synonym: "microtubule basal body of left caudal flagellum" EXACT [GOC:TermGenie]
is_a: GO:0036064 ! ciliary basal body
intersection_of: GO:0036064 ! ciliary basal body
intersection_of: part_of GO:0097560 ! left caudal flagellum
relationship: part_of GO:0097560 ! left caudal flagellum
created_by: pr
creation_date: 2014-02-05T15:00:36Z

[Term]
id: GO:1902678
name: right caudal basal body
namespace: cellular_component
def: "Any ciliary basal body that is part of a right caudal flagellum found in Giardia species (trophozoite stage)." [GO_REF:0000064, GOC:giardia, GOC:TermGenie, ISBN:9780124260207, PMID:16607022, PMID:5961344]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior.
synonym: "cilial basal body of right caudal cilium" EXACT [GOC:TermGenie]
synonym: "cilial basal body of right caudal flagellum" EXACT [GOC:TermGenie]
synonym: "ciliary basal body of right caudal cilium" EXACT [GOC:TermGenie]
synonym: "ciliary basal body of right caudal flagellum" EXACT [GOC:TermGenie]
synonym: "cilium basal body of right caudal cilium" EXACT [GOC:TermGenie]
synonym: "cilium basal body of right caudal flagellum" EXACT [GOC:TermGenie]
synonym: "microtubule basal body of right caudal cilium" EXACT [GOC:TermGenie]
synonym: "microtubule basal body of right caudal flagellum" EXACT [GOC:TermGenie]
synonym: "right caudal flagellum ciliary basal body" EXACT []
is_a: GO:0036064 ! ciliary basal body
intersection_of: GO:0036064 ! ciliary basal body
intersection_of: part_of GO:0097561 ! right caudal flagellum
relationship: part_of GO:0097561 ! right caudal flagellum
created_by: pr
creation_date: 2014-02-05T15:02:56Z

[Term]
id: GO:1902679
name: negative regulation of RNA biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie]
synonym: "down regulation of RNA anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of RNA biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of RNA biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of RNA formation" EXACT [GOC:TermGenie]
synonym: "down regulation of RNA synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA formation" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of RNA anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of RNA biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of RNA biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of RNA formation" NARROW [GOC:TermGenie]
synonym: "inhibition of RNA synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of RNA anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of RNA biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of RNA formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of RNA synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0051253 ! negative regulation of RNA metabolic process
is_a: GO:2001141 ! regulation of RNA biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032774 ! RNA biosynthetic process
relationship: negatively_regulates GO:0032774 ! RNA biosynthetic process
created_by: jl
creation_date: 2014-02-05T16:32:01Z

[Term]
id: GO:1902680
name: positive regulation of RNA biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie]
synonym: "activation of RNA anabolism" NARROW [GOC:TermGenie]
synonym: "activation of RNA biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of RNA biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of RNA formation" NARROW [GOC:TermGenie]
synonym: "activation of RNA synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of RNA anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of RNA biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of RNA formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of RNA synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of RNA anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of RNA biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of RNA biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of RNA formation" EXACT [GOC:TermGenie]
synonym: "up regulation of RNA synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNA anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNA biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNA biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNA formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNA synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA formation" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0051254 ! positive regulation of RNA metabolic process
is_a: GO:2001141 ! regulation of RNA biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032774 ! RNA biosynthetic process
relationship: positively_regulates GO:0032774 ! RNA biosynthetic process
created_by: jl
creation_date: 2014-02-05T16:32:10Z

[Term]
id: GO:1902681
name: regulation of replication fork arrest at rDNA repeats
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of replication fork arrest at rDNA repeats." [GO_REF:0000058, GOC:TermGenie, PMID:23260662]
synonym: "regulation of replication fork arrest at ribosomal DNA repeats" EXACT [GOC:TermGenie]
synonym: "regulation of replication fork blocking at rDNA repeats" EXACT [GOC:TermGenie]
is_a: GO:0033044 ! regulation of chromosome organization
is_a: GO:0090329 ! regulation of DNA-dependent DNA replication
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031582 ! replication fork arrest at rDNA repeats
relationship: regulates GO:0031582 ! replication fork arrest at rDNA repeats
created_by: mah
creation_date: 2014-02-05T16:59:21Z

[Term]
id: GO:1902682
name: protein localization to nuclear pericentric heterochromatin
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a nuclear pericentric heterochromatin." [GO_REF:0000087, GOC:TermGenie, PMID:20211136]
synonym: "protein localisation in nuclear centromeric heterochromatin" EXACT [GOC:TermGenie]
synonym: "protein localisation to nuclear centromeric heterochromatin" EXACT [GOC:TermGenie]
synonym: "protein localization in nuclear centromeric heterochromatin" EXACT [GOC:TermGenie]
is_a: GO:0034504 ! protein localization to nucleus
is_a: GO:0071459 ! protein localization to chromosome, centromeric region
is_a: GO:0097355 ! protein localization to heterochromatin
created_by: mah
creation_date: 2014-02-05T16:59:30Z

[Term]
id: GO:1902683
name: regulation of receptor localization to synapse
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of receptor localization to synapse." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:22252129]
synonym: "regulation of receptor localisation to synapse" EXACT [GOC:TermGenie]
is_a: GO:1902473 ! regulation of protein localization to synapse
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097120 ! receptor localization to synapse
relationship: regulates GO:0097120 ! receptor localization to synapse
created_by: kmv
creation_date: 2014-02-07T17:38:31Z

[Term]
id: GO:1902684
name: negative regulation of receptor localization to synapse
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of receptor localization to synapse." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:22252129]
synonym: "down regulation of receptor localisation to synapse" EXACT [GOC:TermGenie]
synonym: "down regulation of receptor localization to synapse" EXACT [GOC:TermGenie]
synonym: "down-regulation of receptor localisation to synapse" EXACT [GOC:TermGenie]
synonym: "down-regulation of receptor localization to synapse" EXACT [GOC:TermGenie]
synonym: "downregulation of receptor localisation to synapse" EXACT [GOC:TermGenie]
synonym: "downregulation of receptor localization to synapse" EXACT [GOC:TermGenie]
synonym: "inhibition of receptor localisation to synapse" NARROW [GOC:TermGenie]
synonym: "inhibition of receptor localization to synapse" NARROW [GOC:TermGenie]
synonym: "negative regulation of receptor localisation to synapse" EXACT [GOC:TermGenie]
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:1902683 ! regulation of receptor localization to synapse
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097120 ! receptor localization to synapse
relationship: negatively_regulates GO:0097120 ! receptor localization to synapse
created_by: kmv
creation_date: 2014-02-07T17:38:41Z

[Term]
id: GO:1902685
name: positive regulation of receptor localization to synapse
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of receptor localization to synapse." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:22252129]
synonym: "activation of receptor localisation to synapse" NARROW [GOC:TermGenie]
synonym: "activation of receptor localization to synapse" NARROW [GOC:TermGenie]
synonym: "positive regulation of receptor localisation to synapse" EXACT [GOC:TermGenie]
synonym: "up regulation of receptor localisation to synapse" EXACT [GOC:TermGenie]
synonym: "up regulation of receptor localization to synapse" EXACT [GOC:TermGenie]
synonym: "up-regulation of receptor localisation to synapse" EXACT [GOC:TermGenie]
synonym: "up-regulation of receptor localization to synapse" EXACT [GOC:TermGenie]
synonym: "upregulation of receptor localisation to synapse" EXACT [GOC:TermGenie]
synonym: "upregulation of receptor localization to synapse" EXACT [GOC:TermGenie]
is_a: GO:1902474 ! positive regulation of protein localization to synapse
is_a: GO:1902683 ! regulation of receptor localization to synapse
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097120 ! receptor localization to synapse
relationship: positively_regulates GO:0097120 ! receptor localization to synapse
created_by: kmv
creation_date: 2014-02-07T17:38:51Z

[Term]
id: GO:1902686
name: mitochondrial outer membrane permeabilization involved in programmed cell death
namespace: biological_process
def: "The process by which the mitochondrial outer membrane becomes permeable to the passing of proteins and other molecules from the intermembrane space to the cytosol as part of a programmed cell death process." [GO_REF:0000060, GOC:mtg_apoptosis, GOC:pg, GOC:TermGenie, PMID:20151314]
synonym: "mitochondrial membrane permeability transition involved in caspase-independent apoptosis" RELATED [GOC:TermGenie]
synonym: "mitochondrial membrane permeability transition involved in caspase-independent cell death" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane permeability transition involved in non-apoptotic programmed cell death" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane permeability transition involved in nonapoptotic programmed cell death" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane permeability transition involved in PCD" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane permeability transition involved in programmed cell death" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane permeability transition involved in regulated cell death" RELATED [GOC:TermGenie]
synonym: "mitochondrial membrane permeabilization involved in caspase-independent apoptosis" RELATED [GOC:TermGenie]
synonym: "mitochondrial membrane permeabilization involved in caspase-independent cell death" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane permeabilization involved in non-apoptotic programmed cell death" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane permeabilization involved in nonapoptotic programmed cell death" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane permeabilization involved in PCD" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane permeabilization involved in programmed cell death" NARROW [GOC:TermGenie]
synonym: "mitochondrial membrane permeabilization involved in regulated cell death" RELATED [GOC:TermGenie]
synonym: "mitochondrial outer membrane permeabilization during programmed cell death" EXACT []
synonym: "mitochondrial permeability transition involved in caspase-independent apoptosis" RELATED [GOC:TermGenie]
synonym: "mitochondrial permeability transition involved in caspase-independent cell death" NARROW [GOC:TermGenie]
synonym: "mitochondrial permeability transition involved in non-apoptotic programmed cell death" NARROW [GOC:TermGenie]
synonym: "mitochondrial permeability transition involved in nonapoptotic programmed cell death" NARROW [GOC:TermGenie]
synonym: "mitochondrial permeability transition involved in PCD" NARROW [GOC:TermGenie]
synonym: "mitochondrial permeability transition involved in programmed cell death" NARROW [GOC:TermGenie]
synonym: "mitochondrial permeability transition involved in regulated cell death" RELATED [GOC:TermGenie]
synonym: "MPT involved in caspase-independent apoptosis" RELATED [GOC:TermGenie]
synonym: "MPT involved in caspase-independent cell death" NARROW [GOC:TermGenie]
synonym: "MPT involved in non-apoptotic programmed cell death" NARROW [GOC:TermGenie]
synonym: "MPT involved in nonapoptotic programmed cell death" NARROW [GOC:TermGenie]
synonym: "MPT involved in PCD" NARROW [GOC:TermGenie]
synonym: "MPT involved in programmed cell death" NARROW [GOC:TermGenie]
synonym: "MPT involved in regulated cell death" RELATED [GOC:TermGenie]
synonym: "positive regulation of mitochondrial membrane permeability involved in caspase-independent apoptosis" RELATED [GOC:TermGenie]
synonym: "positive regulation of mitochondrial membrane permeability involved in caspase-independent cell death" NARROW [GOC:TermGenie]
synonym: "positive regulation of mitochondrial membrane permeability involved in non-apoptotic programmed cell death" NARROW [GOC:TermGenie]
synonym: "positive regulation of mitochondrial membrane permeability involved in nonapoptotic programmed cell death" NARROW [GOC:TermGenie]
synonym: "positive regulation of mitochondrial membrane permeability involved in PCD" EXACT [GOC:TermGenie]
synonym: "positive regulation of mitochondrial membrane permeability involved in programmed cell death" EXACT []
synonym: "positive regulation of mitochondrial membrane permeability involved in regulated cell death" RELATED [GOC:TermGenie]
synonym: "positive regulation of transport across mitochondrial membrane involved in caspase-independent apoptosis" RELATED [GOC:TermGenie]
synonym: "positive regulation of transport across mitochondrial membrane involved in caspase-independent cell death" NARROW [GOC:TermGenie]
synonym: "positive regulation of transport across mitochondrial membrane involved in non-apoptotic programmed cell death" NARROW [GOC:TermGenie]
synonym: "positive regulation of transport across mitochondrial membrane involved in nonapoptotic programmed cell death" NARROW [GOC:TermGenie]
synonym: "positive regulation of transport across mitochondrial membrane involved in PCD" EXACT [GOC:TermGenie]
synonym: "positive regulation of transport across mitochondrial membrane involved in programmed cell death" EXACT [GOC:TermGenie]
synonym: "positive regulation of transport across mitochondrial membrane involved in regulated cell death" RELATED [GOC:TermGenie]
is_a: GO:0035794 ! positive regulation of mitochondrial membrane permeability
intersection_of: GO:0035794 ! positive regulation of mitochondrial membrane permeability
intersection_of: part_of GO:0012501 ! programmed cell death
relationship: part_of GO:0012501 ! programmed cell death
created_by: pr
creation_date: 2014-02-10T12:56:34Z

[Term]
id: GO:1902687
name: glucosidase complex
namespace: cellular_component
def: "A protein complex which is capable of glucosidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:23826932]
comment: An example of this is ygjK in E. coli (P42592) in PMID:23826932.
is_a: GO:1902494 ! catalytic complex
created_by: bhm
creation_date: 2014-02-12T10:55:10Z

[Term]
id: GO:1902688
name: regulation of NAD metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of NAD metabolic process." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:19846558]
synonym: "regulation of NAD (oxidized) metabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of NAD (oxidized) metabolism" EXACT [GOC:TermGenie]
synonym: "regulation of NAD metabolism" EXACT [GOC:TermGenie]
synonym: "regulation of NAD phosphorylation and dephosphorylation" NARROW [GOC:TermGenie]
synonym: "regulation of nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie]
synonym: "regulation of oxidized NAD metabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of oxidized NAD metabolism" EXACT [GOC:TermGenie]
synonym: "regulation of oxidized nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of oxidized nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006140 ! regulation of nucleotide metabolic process
is_a: GO:0051196 ! regulation of coenzyme metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019674 ! NAD metabolic process
relationship: regulates GO:0019674 ! NAD metabolic process
created_by: di
creation_date: 2014-02-12T18:58:50Z

[Term]
id: GO:1902689
name: negative regulation of NAD metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of NAD metabolic process." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:19846558]
synonym: "down regulation of NAD (oxidized) metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of NAD (oxidized) metabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of NAD metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of NAD metabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of NAD phosphorylation and dephosphorylation" NARROW [GOC:TermGenie]
synonym: "down regulation of nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of oxidized NAD metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of oxidized NAD metabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of oxidized nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of oxidized nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of NAD (oxidized) metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of NAD (oxidized) metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of NAD metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of NAD metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of NAD phosphorylation and dephosphorylation" NARROW [GOC:TermGenie]
synonym: "down-regulation of nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of oxidized NAD metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of oxidized NAD metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of oxidized nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of oxidized nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of NAD (oxidized) metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of NAD (oxidized) metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of NAD metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of NAD metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of NAD phosphorylation and dephosphorylation" NARROW [GOC:TermGenie]
synonym: "downregulation of nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of oxidized NAD metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of oxidized NAD metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of oxidized nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of oxidized nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of NAD (oxidized) metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of NAD (oxidized) metabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of NAD metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of NAD metabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of NAD phosphorylation and dephosphorylation" NARROW [GOC:TermGenie]
synonym: "inhibition of nicotinamide adenine dinucleotide metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of nicotinamide adenine dinucleotide metabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of oxidized NAD metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of oxidized NAD metabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of oxidized nicotinamide adenine dinucleotide metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of oxidized nicotinamide adenine dinucleotide metabolism" NARROW [GOC:TermGenie]
synonym: "negative regulation of NAD (oxidized) metabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of NAD (oxidized) metabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of NAD metabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of NAD phosphorylation and dephosphorylation" NARROW [GOC:TermGenie]
synonym: "negative regulation of nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of oxidized NAD metabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of oxidized NAD metabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of oxidized nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of oxidized nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie]
is_a: GO:0045980 ! negative regulation of nucleotide metabolic process
is_a: GO:0051198 ! negative regulation of coenzyme metabolic process
is_a: GO:1902688 ! regulation of NAD metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019674 ! NAD metabolic process
relationship: negatively_regulates GO:0019674 ! NAD metabolic process
created_by: di
creation_date: 2014-02-12T18:58:59Z

[Term]
id: GO:1902690
name: positive regulation of NAD metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of NAD metabolic process." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:19846558]
synonym: "activation of NAD (oxidized) metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of NAD (oxidized) metabolism" NARROW [GOC:TermGenie]
synonym: "activation of NAD metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of NAD metabolism" NARROW [GOC:TermGenie]
synonym: "activation of NAD phosphorylation and dephosphorylation" NARROW [GOC:TermGenie]
synonym: "activation of nicotinamide adenine dinucleotide metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of nicotinamide adenine dinucleotide metabolism" NARROW [GOC:TermGenie]
synonym: "activation of oxidized NAD metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of oxidized NAD metabolism" NARROW [GOC:TermGenie]
synonym: "activation of oxidized nicotinamide adenine dinucleotide metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of oxidized nicotinamide adenine dinucleotide metabolism" NARROW [GOC:TermGenie]
synonym: "positive regulation of NAD (oxidized) metabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of NAD (oxidized) metabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of NAD metabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of NAD phosphorylation and dephosphorylation" NARROW [GOC:TermGenie]
synonym: "positive regulation of nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of oxidized NAD metabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of oxidized NAD metabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of oxidized nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of oxidized nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of NAD (oxidized) metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of NAD (oxidized) metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of NAD metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of NAD metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of NAD phosphorylation and dephosphorylation" NARROW [GOC:TermGenie]
synonym: "up regulation of nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of oxidized NAD metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of oxidized NAD metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of oxidized nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of oxidized nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of NAD (oxidized) metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of NAD (oxidized) metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of NAD metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of NAD metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of NAD phosphorylation and dephosphorylation" NARROW [GOC:TermGenie]
synonym: "up-regulation of nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of oxidized NAD metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of oxidized NAD metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of oxidized nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of oxidized nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of NAD (oxidized) metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of NAD (oxidized) metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of NAD metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of NAD metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of NAD phosphorylation and dephosphorylation" NARROW [GOC:TermGenie]
synonym: "upregulation of nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of oxidized NAD metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of oxidized NAD metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of oxidized nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of oxidized nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie]
is_a: GO:0045981 ! positive regulation of nucleotide metabolic process
is_a: GO:0051197 ! positive regulation of coenzyme metabolic process
is_a: GO:1902688 ! regulation of NAD metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0019674 ! NAD metabolic process
relationship: positively_regulates GO:0019674 ! NAD metabolic process
created_by: di
creation_date: 2014-02-12T18:59:09Z

[Term]
id: GO:1902691
name: respiratory basal cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a respiratory basal cell." [GO_REF:0000086, GOC:TermGenie, MP:0011114, PMID:17909629]
comment: Changes in the lineage choice of ABCs or their undifferentiated daughters might contribute to the mucous cell hyperplasia, metaplasia or squamous metaplasia seen in many respiratory disorders
synonym: "airway basal cell differentiation" EXACT [MP:0011114]
is_a: GO:0030855 ! epithelial cell differentiation
is_a: GO:0048863 ! stem cell differentiation
created_by: cjmungall
creation_date: 2014-02-13T23:41:24Z

[Term]
id: GO:1902692
name: regulation of neuroblast proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neuroblast proliferation." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:21168496]
is_a: GO:0050767 ! regulation of neurogenesis
is_a: GO:0072091 ! regulation of stem cell proliferation
is_a: GO:2000177 ! regulation of neural precursor cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007405 ! neuroblast proliferation
relationship: regulates GO:0007405 ! neuroblast proliferation
created_by: rl
creation_date: 2014-02-18T10:03:31Z

[Term]
id: GO:1902693
name: superoxide dismutase complex
namespace: cellular_component
def: "A protein complex which is capable of superoxide dismutase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:10026301]
comment: An example of this is SOD1 in Saccharomyces cerevisiae S288c (UniProt symbol P00445) in PMID:10026301.
is_a: GO:1990204 ! oxidoreductase complex
created_by: bhm
creation_date: 2014-02-18T11:10:11Z

[Term]
id: GO:1902694
name: superoxide dismutase copper chaperone complex
namespace: cellular_component
def: "A protein complex which is capable of superoxide dismutase copper chaperone activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:10426947]
comment: An example of this is CCS1 in Saccharomyces cerevisiae S288c (UniProt symbol P40202) in PMID:10426947.
is_a: GO:1902695 ! metallochaperone complex
created_by: bhm
creation_date: 2014-02-18T11:13:45Z

[Term]
id: GO:1902695
name: metallochaperone complex
namespace: cellular_component
def: "A protein complex which is capable of metallochaperone activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:10426947]
is_a: GO:0043234 ! protein complex
created_by: bhm
creation_date: 2014-02-18T11:34:40Z

[Term]
id: GO:1902696
name: glycine catabolic process to isobutanol
namespace: biological_process
alt_id: GO:1990293
def: "The chemical reactions and pathways resulting in the breakdown of glycine to isobutanol." [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:23642236]
synonym: "glycine breakdown to isobutanol" EXACT [GOC:TermGenie]
synonym: "glycine catabolism to isobutanol" EXACT [GOC:TermGenie]
synonym: "glycine degradation to isobutanol" EXACT [GOC:TermGenie]
is_a: GO:0006546 ! glycine catabolic process
is_a: GO:1901960 ! isobutanol metabolic process
created_by: tb
creation_date: 2014-02-19T18:00:12Z

[Term]
id: GO:1902697
name: valine catabolic process to isobutanol
namespace: biological_process
alt_id: GO:1990292
def: "The chemical reactions and pathways resulting in the breakdown of valine to isobutanol." [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:9748245]
synonym: "valine breakdown to isobutanol" EXACT [GOC:TermGenie]
synonym: "valine catabolism to isobutanol" EXACT [GOC:TermGenie]
synonym: "valine degradation to isobutanol" EXACT [GOC:TermGenie]
is_a: GO:0006574 ! valine catabolic process
is_a: GO:1901960 ! isobutanol metabolic process
created_by: tb
creation_date: 2014-02-19T18:28:19Z

[Term]
id: GO:1902698
name: pentose catabolic process to butyrate
namespace: biological_process
alt_id: GO:1990288
def: "The chemical reactions and pathways resulting in the breakdown of pentose to butyrate." [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:18727018, PMID:19539744]
synonym: "acidogenesis" BROAD [GOC:tt]
synonym: "pentose breakdown to butyrate" EXACT [GOC:TermGenie]
synonym: "pentose catabolism to butyrate" EXACT [GOC:TermGenie]
synonym: "pentose degradation to butyrate" EXACT [GOC:TermGenie]
is_a: GO:0019323 ! pentose catabolic process
is_a: GO:0019605 ! butyrate metabolic process
created_by: tb
creation_date: 2014-02-19T18:28:28Z

[Term]
id: GO:1902699
name: pentose catabolic process to acetate
namespace: biological_process
alt_id: GO:1990289
def: "The chemical reactions and pathways resulting in the breakdown of pentose to acetate." [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:18727018, PMID:19539744]
synonym: "acidogenesis" BROAD [GOC:tt]
synonym: "pentose breakdown to acetate" EXACT [GOC:TermGenie]
synonym: "pentose catabolism to acetate" EXACT [GOC:TermGenie]
synonym: "pentose degradation to acetate" EXACT [GOC:TermGenie]
is_a: GO:0006083 ! acetate metabolic process
is_a: GO:0019323 ! pentose catabolic process
created_by: tb
creation_date: 2014-02-19T18:28:38Z

[Term]
id: GO:1902700
name: pentose catabolic process to butan-1-ol
namespace: biological_process
alt_id: GO:1990290
def: "The chemical reactions and pathways resulting in the breakdown of pentose to butan-1-ol." [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:18727018, PMID:19539744]
synonym: "pentose breakdown to butan-1-ol" EXACT [GOC:TermGenie]
synonym: "pentose catabolic process to 1-butanol" EXACT [GOC:tt]
synonym: "pentose catabolic process to butanol" EXACT [GOC:tt]
synonym: "pentose catabolism to butan-1-ol" EXACT [GOC:TermGenie]
synonym: "pentose degradation to butan-1-ol" EXACT [GOC:TermGenie]
synonym: "solventogenesis" BROAD [GOC:tt]
is_a: GO:0019323 ! pentose catabolic process
is_a: GO:0071270 ! 1-butanol metabolic process
created_by: tb
creation_date: 2014-02-19T18:28:47Z

[Term]
id: GO:1902701
name: pentose catabolic process to propan-2-ol
namespace: biological_process
alt_id: GO:1990291
def: "The chemical reactions and pathways resulting in the breakdown of pentose to propan-2-ol." [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:18727018, PMID:19539744]
synonym: "pentose breakdown to propan-2-ol" EXACT [GOC:TermGenie]
synonym: "pentose catabolic process to isopropanol" EXACT [GOC:tt]
synonym: "pentose catabolic process to isopropyl alcohol" EXACT [GOC:tt]
synonym: "pentose catabolism to propan-2-ol" EXACT [GOC:TermGenie]
synonym: "pentose degradation to propan-2-ol" EXACT [GOC:TermGenie]
synonym: "solventogenesis" BROAD [GOC:tt]
is_a: GO:0019323 ! pentose catabolic process
is_a: GO:1902639 ! propan-2-ol metabolic process
created_by: tb
creation_date: 2014-02-19T18:28:57Z

[Term]
id: GO:1902702
name: hexose catabolic process to propan-2-ol
namespace: biological_process
alt_id: GO:1990283
def: "The chemical reactions and pathways resulting in the breakdown of hexose to propan-2-ol." [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:18727018, PMID:19539744]
synonym: "hexose breakdown to propan-2-ol" EXACT [GOC:TermGenie]
synonym: "hexose catabolic process to isopropanol" EXACT [GOC:tt]
synonym: "hexose catabolic process to isopropyl alcohol" EXACT [GOC:tt]
synonym: "hexose catabolism to propan-2-ol" EXACT [GOC:TermGenie]
synonym: "hexose degradation to propan-2-ol" EXACT [GOC:TermGenie]
synonym: "solventogenesis" RELATED [GOC:tt]
is_a: GO:0019320 ! hexose catabolic process
is_a: GO:1902639 ! propan-2-ol metabolic process
created_by: tb
creation_date: 2014-02-19T18:42:54Z

[Term]
id: GO:1902703
name: hexose catabolic process to butan-1-ol
namespace: biological_process
alt_id: GO:1990284
def: "The chemical reactions and pathways resulting in the breakdown of hexose to butan-1-ol." [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:18727018, PMID:19539744]
synonym: "hexose breakdown to butan-1-ol" EXACT [GOC:TermGenie]
synonym: "hexose catabolic process to 1-butanol" EXACT [GOC:tt]
synonym: "hexose catabolic process to butanol" EXACT [GOC:tt]
synonym: "hexose catabolism to butan-1-ol" EXACT [GOC:TermGenie]
synonym: "hexose degradation to butan-1-ol" EXACT [GOC:TermGenie]
synonym: "solventogenesis" BROAD [GOC:tt]
is_a: GO:0019320 ! hexose catabolic process
is_a: GO:0071270 ! 1-butanol metabolic process
created_by: tb
creation_date: 2014-02-19T18:43:04Z

[Term]
id: GO:1902704
name: hexose catabolic process to acetone
namespace: biological_process
alt_id: GO:1990285
def: "The chemical reactions and pathways resulting in the breakdown of hexose to acetone." [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:18727018, PMID:19539744]
synonym: "hexose breakdown to acetone" EXACT [GOC:TermGenie]
synonym: "hexose catabolic process to 2-propanone" EXACT [GOC:tt]
synonym: "hexose catabolism to acetone" EXACT [GOC:TermGenie]
synonym: "hexose degradation to acetone" EXACT [GOC:TermGenie]
synonym: "solventogenesis" BROAD [GOC:tt]
is_a: GO:0019320 ! hexose catabolic process
is_a: GO:0043443 ! acetone metabolic process
created_by: tb
creation_date: 2014-02-19T18:43:13Z

[Term]
id: GO:1902705
name: hexose catabolic process to butyrate
namespace: biological_process
alt_id: GO:1990287
def: "The chemical reactions and pathways resulting in the breakdown of hexose to butyrate." [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:18727018, PMID:19539744]
synonym: "acidogenesis" BROAD [GOC:tt]
synonym: "hexose breakdown to butyrate" EXACT [GOC:TermGenie]
synonym: "hexose catabolism to butyrate" EXACT [GOC:TermGenie]
synonym: "hexose degradation to butyrate" EXACT [GOC:TermGenie]
is_a: GO:0019320 ! hexose catabolic process
is_a: GO:0019605 ! butyrate metabolic process
created_by: tb
creation_date: 2014-02-19T18:43:32Z

[Term]
id: GO:1902706
name: hexose catabolic process to acetate
namespace: biological_process
alt_id: GO:1990286
def: "The chemical reactions and pathways resulting in the breakdown of hexose to acetate." [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:18727018, PMID:19539744]
synonym: "acidogenesis" BROAD [GOC:tt]
synonym: "hexose breakdown to acetate" EXACT [GOC:TermGenie]
synonym: "hexose catabolism to acetate" EXACT [GOC:TermGenie]
synonym: "hexose degradation to acetate" EXACT [GOC:TermGenie]
is_a: GO:0006083 ! acetate metabolic process
is_a: GO:0019320 ! hexose catabolic process
created_by: tb
creation_date: 2014-02-19T18:43:23Z

[Term]
id: GO:1902707
name: hexose catabolic process to ethanol
namespace: biological_process
alt_id: GO:1990282
def: "The chemical reactions and pathways resulting in the breakdown of hexose to ethanol." [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:18727018, PMID:19539744]
synonym: "hexose breakdown to ethanol" EXACT [GOC:TermGenie]
synonym: "hexose catabolism to ethanol" EXACT [GOC:TermGenie]
synonym: "hexose degradation to ethanol" EXACT [GOC:TermGenie]
synonym: "solventogenesis" BROAD [GOC:tt]
is_a: GO:0006067 ! ethanol metabolic process
is_a: GO:0019320 ! hexose catabolic process
created_by: tb
creation_date: 2014-02-19T21:33:08Z

[Term]
id: GO:1902708
name: response to plumbagin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a plumbagin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23028742]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901654 ! response to ketone
created_by: mah
creation_date: 2014-02-20T13:49:54Z

[Term]
id: GO:1902709
name: cellular response to plumbagin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a plumbagin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23028742]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901655 ! cellular response to ketone
is_a: GO:1902708 ! response to plumbagin
created_by: mah
creation_date: 2014-02-20T13:50:04Z

[Term]
id: GO:1902710
name: GABA receptor complex
namespace: cellular_component
def: "A protein complex which is capable of GABA receptor activity. Upon binding of gamma-aminobutyric acid (GABA) it transmits the signal from one side of the membrane to the other to initiate a change in cell activity. Major inhibitory receptor in vertebrate brain. Also found in other vertebrate tissues, invertebrates and possibly in plants. Effective benzodiazepine receptor." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:18790874]
synonym: "gamma-aminobutyric acid receptor complex" EXACT []
is_a: GO:0043235 ! receptor complex
created_by: bhm
creation_date: 2014-02-20T16:07:48Z

[Term]
id: GO:1902711
name: GABA-A receptor complex
namespace: cellular_component
def: "A protein complex which is capable of GABA-A receptor activity. In human, it is usually composed of either two alpha, two beta and one gamma chain of the GABA-A receptor subunits or 5 chains of the GABA-A receptor subunits rho1-3 (formally known as GABA-C receptor)." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:18790874]
comment: An example of this is GBRA1 in human (UniProt symbol P14867) in PMID:18790874.
is_a: GO:1902710 ! GABA receptor complex
created_by: bhm
creation_date: 2014-02-21T09:19:58Z

[Term]
id: GO:1902712
name: G-protein coupled GABA receptor complex
namespace: cellular_component
def: "A protein complex which is capable of G-protein coupled GABA receptor activity. In human, it is usually a heterodimer composed of GABA-B receptor subunits 1 and 2." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:18790874]
comment: An example of this is GABR1 in human (UniProt symbol Q9UBS5) in PMID:18790874.
is_a: GO:0038037 ! G-protein coupled receptor dimeric complex
is_a: GO:1902710 ! GABA receptor complex
created_by: bhm
creation_date: 2014-02-21T09:47:03Z

[Term]
id: GO:1902713
name: regulation of interferon-gamma secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of interferon-gamma secretion." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:19109405]
synonym: "regulation of IFN-gamma secretion" EXACT [GOC:TermGenie]
synonym: "regulation of IFNG secretion" EXACT [GOC:TermGenie]
synonym: "regulation of type II IFN secretion" BROAD [GOC:TermGenie]
synonym: "regulation of type II interferon secretion" BROAD [GOC:TermGenie]
is_a: GO:0032649 ! regulation of interferon-gamma production
is_a: GO:0050707 ! regulation of cytokine secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072643 ! interferon-gamma secretion
relationship: regulates GO:0072643 ! interferon-gamma secretion
created_by: als
creation_date: 2014-02-21T16:34:19Z

[Term]
id: GO:1902714
name: negative regulation of interferon-gamma secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of interferon-gamma secretion." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:19109405]
synonym: "down regulation of IFN-gamma secretion" EXACT [GOC:TermGenie]
synonym: "down regulation of IFNG secretion" EXACT [GOC:TermGenie]
synonym: "down regulation of interferon-gamma secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of IFN-gamma secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of IFNG secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of interferon-gamma secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of IFN-gamma secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of IFNG secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of interferon-gamma secretion" EXACT [GOC:TermGenie]
synonym: "inhibition of IFN-gamma secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of IFNG secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of interferon-gamma secretion" NARROW [GOC:TermGenie]
synonym: "negative regulation of IFN-gamma secretion" EXACT [GOC:TermGenie]
synonym: "negative regulation of IFNG secretion" EXACT [GOC:TermGenie]
is_a: GO:0032689 ! negative regulation of interferon-gamma production
is_a: GO:0050710 ! negative regulation of cytokine secretion
is_a: GO:1902713 ! regulation of interferon-gamma secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072643 ! interferon-gamma secretion
relationship: negatively_regulates GO:0072643 ! interferon-gamma secretion
created_by: als
creation_date: 2014-02-21T16:34:29Z

[Term]
id: GO:1902715
name: positive regulation of interferon-gamma secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of interferon-gamma secretion." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:19109405]
synonym: "activation of IFN-gamma secretion" NARROW [GOC:TermGenie]
synonym: "activation of IFNG secretion" NARROW [GOC:TermGenie]
synonym: "activation of interferon-gamma secretion" NARROW [GOC:TermGenie]
synonym: "positive regulation of IFN-gamma secretion" EXACT [GOC:TermGenie]
synonym: "positive regulation of IFNG secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of IFN-gamma secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of IFNG secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of interferon-gamma secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of IFN-gamma secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of IFNG secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of interferon-gamma secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of IFN-gamma secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of IFNG secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of interferon-gamma secretion" EXACT [GOC:TermGenie]
is_a: GO:0032729 ! positive regulation of interferon-gamma production
is_a: GO:0050715 ! positive regulation of cytokine secretion
is_a: GO:1902713 ! regulation of interferon-gamma secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072643 ! interferon-gamma secretion
relationship: positively_regulates GO:0072643 ! interferon-gamma secretion
created_by: als
creation_date: 2014-02-21T16:34:38Z

[Term]
id: GO:1902716
name: cell cortex of growing cell tip
namespace: cellular_component
def: "Any cell cortex that is part of a growing cell tip." [GO_REF:0000064, GOC:TermGenie, PMID:24146635]
synonym: "cell cortex of growing cell end" EXACT []
is_a: GO:0051285 ! cell cortex of cell tip
intersection_of: GO:0099738 ! cell cortex region
intersection_of: part_of GO:0035838 ! growing cell tip
relationship: part_of GO:0035838 ! growing cell tip
created_by: mah
creation_date: 2014-02-24T15:46:57Z

[Term]
id: GO:1902717
name: obsolete sequestering of iron ion
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of sequestering of iron ion." [GO_REF:0000058, GOC:TermGenie, PMID:3099306]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "sequestering of iron ion" EXACT []
is_obsolete: true
created_by: mrice
creation_date: 2014-02-24T16:08:43Z

[Term]
id: GO:1902718
name: obsolete sequestering of copper ion
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of sequestering of copper ion." [GO_REF:0000058, GOC:TermGenie, PMID:3099306]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "sequestering of copper ion" EXACT []
is_obsolete: true
created_by: mrice
creation_date: 2014-02-24T16:08:53Z

[Term]
id: GO:1902719
name: obsolete extracellular sequestering of copper ion
namespace: biological_process
def: "OBSOLETE. The process of binding or confining copper ions in an extracellular area such that they are separated from other components of a biological system." [GO_REF:0000058, GOC:TermGenie, PMID:3099306]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "extracellular sequestering of copper ion" EXACT []
is_obsolete: true
created_by: mrice
creation_date: 2014-02-24T16:09:09Z

[Term]
id: GO:1902720
name: obsolete intracellular sequestering of copper ion
namespace: biological_process
def: "OBSOLETE. The process of binding or confining copper ions in an intracellular area such that they are separated from other components of a biological system." [GO_REF:0000058, GOC:TermGenie, PMID:3099306]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "intracellular sequestering of copper ion" EXACT []
is_obsolete: true
created_by: mrice
creation_date: 2014-02-24T16:09:18Z

[Term]
id: GO:1902721
name: negative regulation of prolactin secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of prolactin secretion." [GO_REF:0000058, GOC:TermGenie, PMID:16159377]
synonym: "down regulation of prolactin secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of prolactin secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of prolactin secretion" EXACT [GOC:TermGenie]
synonym: "inhibition of prolactin secretion" NARROW [GOC:TermGenie]
is_a: GO:0050709 ! negative regulation of protein secretion
is_a: GO:0090278 ! negative regulation of peptide hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070459 ! prolactin secretion
relationship: negatively_regulates GO:0070459 ! prolactin secretion
created_by: mrice
creation_date: 2014-02-24T16:09:28Z

[Term]
id: GO:1902722
name: positive regulation of prolactin secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of prolactin secretion." [GO_REF:0000058, GOC:TermGenie, PMID:16159377]
synonym: "activation of prolactin secretion" NARROW [GOC:TermGenie]
synonym: "up regulation of prolactin secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of prolactin secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of prolactin secretion" EXACT [GOC:TermGenie]
is_a: GO:0050714 ! positive regulation of protein secretion
is_a: GO:0090277 ! positive regulation of peptide hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070459 ! prolactin secretion
relationship: positively_regulates GO:0070459 ! prolactin secretion
created_by: mrice
creation_date: 2014-02-24T16:09:37Z

[Term]
id: GO:1902723
name: negative regulation of skeletal muscle satellite cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of satellite cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:23212449]
synonym: "down regulation of satellite cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of satellite cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of satellite cell proliferation" EXACT [GOC:TermGenie]
synonym: "inhibition of satellite cell proliferation" NARROW [GOC:TermGenie]
is_a: GO:0014842 ! regulation of skeletal muscle satellite cell proliferation
is_a: GO:0014859 ! negative regulation of skeletal muscle cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0014841 ! skeletal muscle satellite cell proliferation
relationship: negatively_regulates GO:0014841 ! skeletal muscle satellite cell proliferation
created_by: mrice
creation_date: 2014-02-24T16:09:46Z

[Term]
id: GO:1902724
name: positive regulation of skeletal muscle satellite cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of skeletal muscle satellite cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:23212449]
synonym: "activation of satellite cell proliferation" NARROW [GOC:TermGenie]
synonym: "up regulation of satellite cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of satellite cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of satellite cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0014842 ! regulation of skeletal muscle satellite cell proliferation
is_a: GO:0014858 ! positive regulation of skeletal muscle cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0014841 ! skeletal muscle satellite cell proliferation
relationship: positively_regulates GO:0014841 ! skeletal muscle satellite cell proliferation
created_by: mrice
creation_date: 2014-02-24T16:09:56Z

[Term]
id: GO:1902725
name: negative regulation of satellite cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of satellite cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:23212449]
synonym: "down regulation of satellite cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of satellite cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of satellite cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of satellite cell differentiation" NARROW [GOC:TermGenie]
is_a: GO:2000737 ! negative regulation of stem cell differentiation
is_a: GO:2001015 ! negative regulation of skeletal muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0014816 ! skeletal muscle satellite cell differentiation
relationship: negatively_regulates GO:0014816 ! skeletal muscle satellite cell differentiation
created_by: mrice
creation_date: 2014-02-24T16:10:05Z

[Term]
id: GO:1902726
name: positive regulation of skeletal muscle satellite cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of satellite cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:23212449]
synonym: "activation of satellite cell differentiation" NARROW [GOC:TermGenie]
synonym: "up regulation of satellite cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of satellite cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of satellite cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:2000738 ! positive regulation of stem cell differentiation
is_a: GO:2001016 ! positive regulation of skeletal muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0014816 ! skeletal muscle satellite cell differentiation
relationship: positively_regulates GO:0014816 ! skeletal muscle satellite cell differentiation
created_by: mrice
creation_date: 2014-02-24T16:10:14Z

[Term]
id: GO:1902727
name: negative regulation of growth factor dependent skeletal muscle satellite cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of satellite cell proliferation; dependent on specific growth factor activity such as fibroblast growth factors and transforming growth factor beta." [GO_REF:0000058, GOC:TermGenie, PMID:23212449]
is_a: GO:1902723 ! negative regulation of skeletal muscle satellite cell proliferation
relationship: negatively_regulates GO:0014841 ! skeletal muscle satellite cell proliferation
created_by: mrice
creation_date: 2014-02-24T16:10:24Z

[Term]
id: GO:1902728
name: positive regulation of growth factor dependent skeletal muscle satellite cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of satellite cell proliferation; dependent on specific growth factor activity such as fibroblast growth factors and transforming growth factor beta." [GO_REF:0000058, GOC:TermGenie, PMID:23212449]
is_a: GO:1902724 ! positive regulation of skeletal muscle satellite cell proliferation
relationship: positively_regulates GO:0014841 ! skeletal muscle satellite cell proliferation
created_by: mrice
creation_date: 2014-02-24T16:10:33Z

[Term]
id: GO:1902729
name: negative regulation of proteoglycan biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [GO_REF:0000058, GOC:TermGenie, PMID:23212449]
synonym: "down regulation of proteoglycan anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of proteoglycan biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of proteoglycan biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of proteoglycan formation" EXACT [GOC:TermGenie]
synonym: "down regulation of proteoglycan synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of proteoglycan anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of proteoglycan biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of proteoglycan biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of proteoglycan formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of proteoglycan synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of proteoglycan anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of proteoglycan biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of proteoglycan biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of proteoglycan formation" EXACT [GOC:TermGenie]
synonym: "downregulation of proteoglycan synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of proteoglycan anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of proteoglycan biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of proteoglycan biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of proteoglycan formation" NARROW [GOC:TermGenie]
synonym: "inhibition of proteoglycan synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of proteoglycan anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of proteoglycan biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of proteoglycan formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of proteoglycan synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030166 ! proteoglycan biosynthetic process
relationship: negatively_regulates GO:0030166 ! proteoglycan biosynthetic process
created_by: mrice
creation_date: 2014-02-24T16:10:43Z

[Term]
id: GO:1902730
name: positive regulation of proteoglycan biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [GO_REF:0000058, GOC:TermGenie, PMID:23212449]
synonym: "activation of proteoglycan anabolism" NARROW [GOC:TermGenie]
synonym: "activation of proteoglycan biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of proteoglycan biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of proteoglycan formation" NARROW [GOC:TermGenie]
synonym: "activation of proteoglycan synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of proteoglycan anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of proteoglycan biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of proteoglycan formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of proteoglycan synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of proteoglycan anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of proteoglycan biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of proteoglycan biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of proteoglycan formation" EXACT [GOC:TermGenie]
synonym: "up regulation of proteoglycan synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of proteoglycan anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of proteoglycan biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of proteoglycan biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of proteoglycan formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of proteoglycan synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of proteoglycan anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of proteoglycan biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of proteoglycan biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of proteoglycan formation" EXACT [GOC:TermGenie]
synonym: "upregulation of proteoglycan synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030166 ! proteoglycan biosynthetic process
relationship: positively_regulates GO:0030166 ! proteoglycan biosynthetic process
created_by: mrice
creation_date: 2014-02-24T16:10:52Z

[Term]
id: GO:1902731
name: negative regulation of chondrocyte proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population. A chondrocyte is a polymorphic cell that forms cartilage." [GO_REF:0000058, GOC:TermGenie, PMID:23212449]
synonym: "down regulation of cartilage cell proliferation" EXACT [GOC:TermGenie]
synonym: "down regulation of chondrocyte cell proliferation" EXACT [GOC:TermGenie]
synonym: "down regulation of chondrocyte proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of cartilage cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of chondrocyte cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of chondrocyte proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of cartilage cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of chondrocyte cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of chondrocyte proliferation" EXACT [GOC:TermGenie]
synonym: "inhibition of cartilage cell proliferation" NARROW [GOC:TermGenie]
synonym: "inhibition of chondrocyte cell proliferation" NARROW [GOC:TermGenie]
synonym: "inhibition of chondrocyte proliferation" NARROW [GOC:TermGenie]
synonym: "negative regulation of cartilage cell proliferation" EXACT [GOC:TermGenie]
synonym: "negative regulation of chondrocyte cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0008285 ! negative regulation of cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035988 ! chondrocyte proliferation
relationship: negatively_regulates GO:0035988 ! chondrocyte proliferation
created_by: mrice
creation_date: 2014-02-24T16:11:02Z

[Term]
id: GO:1902732
name: positive regulation of chondrocyte proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population. A chondrocyte is a polymorphic cell that forms cartilage." [GO_REF:0000058, GOC:TermGenie, PMID:23212449]
synonym: "activation of cartilage cell proliferation" NARROW [GOC:TermGenie]
synonym: "activation of chondrocyte cell proliferation" NARROW [GOC:TermGenie]
synonym: "activation of chondrocyte proliferation" NARROW [GOC:TermGenie]
synonym: "positive regulation of cartilage cell proliferation" EXACT [GOC:TermGenie]
synonym: "positive regulation of chondrocyte cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of cartilage cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of chondrocyte cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of chondrocyte proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of cartilage cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of chondrocyte cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of chondrocyte proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of cartilage cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of chondrocyte cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of chondrocyte proliferation" EXACT [GOC:TermGenie]
is_a: GO:0008284 ! positive regulation of cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035988 ! chondrocyte proliferation
relationship: positively_regulates GO:0035988 ! chondrocyte proliferation
created_by: mrice
creation_date: 2014-02-24T16:11:18Z

[Term]
id: GO:1902733
name: regulation of growth plate cartilage chondrocyte differentiation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the growth of a bone. A chondrocyte is a polymorphic cell that forms cartilage" [GO_REF:0000058, GOC:TermGenie, PMID:23212449]
is_a: GO:0046620 ! regulation of organ growth
is_a: GO:1902738 ! regulation of chondrocyte differentiation involved in endochondral bone morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003418 ! growth plate cartilage chondrocyte differentiation
relationship: regulates GO:0003418 ! growth plate cartilage chondrocyte differentiation
created_by: mrice
creation_date: 2014-02-24T16:11:28Z

[Term]
id: GO:1902734
name: regulation of receptor-mediated virion attachment to host cell
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of receptor-mediated virion attachment to host cell." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18385238]
synonym: "regulation of virion attachment, binding of host cell surface receptor" EXACT [GOC:TermGenie]
is_a: GO:1903900 ! regulation of viral life cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0046813 ! receptor-mediated virion attachment to host cell
relationship: regulates GO:0046813 ! receptor-mediated virion attachment to host cell
created_by: als
creation_date: 2014-02-25T12:25:56Z

[Term]
id: GO:1902735
name: negative regulation of receptor-mediated virion attachment to host cell
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of receptor-mediated virion attachment to host cell." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18385238]
synonym: "down regulation of receptor-mediated virion attachment to host cell" EXACT [GOC:TermGenie]
synonym: "down regulation of virion attachment, binding of host cell surface receptor" EXACT [GOC:TermGenie]
synonym: "down-regulation of receptor-mediated virion attachment to host cell" EXACT [GOC:TermGenie]
synonym: "down-regulation of virion attachment, binding of host cell surface receptor" EXACT [GOC:TermGenie]
synonym: "downregulation of receptor-mediated virion attachment to host cell" EXACT [GOC:TermGenie]
synonym: "downregulation of virion attachment, binding of host cell surface receptor" EXACT [GOC:TermGenie]
synonym: "inhibition of receptor-mediated virion attachment to host cell" NARROW [GOC:TermGenie]
synonym: "inhibition of virion attachment, binding of host cell surface receptor" NARROW [GOC:TermGenie]
synonym: "negative regulation of virion attachment, binding of host cell surface receptor" EXACT [GOC:TermGenie]
is_a: GO:1902734 ! regulation of receptor-mediated virion attachment to host cell
is_a: GO:1903901 ! negative regulation of viral life cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0046813 ! receptor-mediated virion attachment to host cell
relationship: negatively_regulates GO:0046813 ! receptor-mediated virion attachment to host cell
created_by: als
creation_date: 2014-02-25T12:26:06Z

[Term]
id: GO:1902736
name: positive regulation of receptor-mediated virion attachment to host cell
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of receptor-mediated virion attachment to host cell." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18385238]
synonym: "activation of receptor-mediated virion attachment to host cell" NARROW [GOC:TermGenie]
synonym: "activation of virion attachment, binding of host cell surface receptor" NARROW [GOC:TermGenie]
synonym: "positive regulation of virion attachment, binding of host cell surface receptor" EXACT [GOC:TermGenie]
synonym: "up regulation of receptor-mediated virion attachment to host cell" EXACT [GOC:TermGenie]
synonym: "up regulation of virion attachment, binding of host cell surface receptor" EXACT [GOC:TermGenie]
synonym: "up-regulation of receptor-mediated virion attachment to host cell" EXACT [GOC:TermGenie]
synonym: "up-regulation of virion attachment, binding of host cell surface receptor" EXACT [GOC:TermGenie]
synonym: "upregulation of receptor-mediated virion attachment to host cell" EXACT [GOC:TermGenie]
synonym: "upregulation of virion attachment, binding of host cell surface receptor" EXACT [GOC:TermGenie]
is_a: GO:1902734 ! regulation of receptor-mediated virion attachment to host cell
is_a: GO:1903902 ! positive regulation of viral life cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0046813 ! receptor-mediated virion attachment to host cell
relationship: positively_regulates GO:0046813 ! receptor-mediated virion attachment to host cell
created_by: als
creation_date: 2014-02-25T12:26:16Z

[Term]
id: GO:1902737
name: dendritic filopodium
namespace: cellular_component
def: "A small, membranous protrusion found primarily on dendritic stretches of developing neurons. May receive synaptic input, and can develop into dendritic spines." [GO_REF:0000064, GOC:pad, GOC:PARL, GOC:TermGenie, http://en.wikipedia.org/wiki/Dendritic_filopodia, PMID:24464040]
comment: Dendritic filopodia are generally less-well studied than dendritic spines because their transient nature makes them difficult to detect with traditional microscopy techniques, and because they are sometimes destroyed by sample preparation. Note that filopodia on dendritic shafts are distinct from other types of filopodia (even those found in dendritic growth cones) and may react differently to stimuli, as shown in PMID:12904473.
synonym: "dendrite filopodium" EXACT []
is_a: GO:0030175 ! filopodium
is_a: GO:0044463 ! cell projection part
is_a: GO:0097458 ! neuron part
intersection_of: GO:0030175 ! filopodium
intersection_of: part_of GO:0030425 ! dendrite
relationship: part_of GO:0030425 ! dendrite
created_by: pr
creation_date: 2014-02-26T14:28:26Z

[Term]
id: GO:1902738
name: regulation of chondrocyte differentiation involved in endochondral bone morphogenesis
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage." [GO_REF:0000058, GOC:TermGenie, PMID:8662546]
is_a: GO:0032330 ! regulation of chondrocyte differentiation
is_a: GO:1903010 ! regulation of bone development
is_a: GO:2000027 ! regulation of organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003413 ! chondrocyte differentiation involved in endochondral bone morphogenesis
relationship: regulates GO:0003413 ! chondrocyte differentiation involved in endochondral bone morphogenesis
created_by: mrice
creation_date: 2014-02-26T15:36:15Z

[Term]
id: GO:1902739
name: regulation of interferon-alpha secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of interferon-alpha secretion." [GO_REF:0000058, GOC:TermGenie, PMID:19262501]
synonym: "regulation of IFN-alpha secretion" EXACT [GOC:TermGenie]
synonym: "regulation of IFNA secretion" EXACT [GOC:TermGenie]
is_a: GO:0032647 ! regulation of interferon-alpha production
is_a: GO:0050707 ! regulation of cytokine secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072642 ! interferon-alpha secretion
relationship: regulates GO:0072642 ! interferon-alpha secretion
created_by: mrice
creation_date: 2014-02-26T22:13:20Z

[Term]
id: GO:1902740
name: negative regulation of interferon-alpha secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of interferon-alpha secretion." [GO_REF:0000058, GOC:TermGenie, PMID:19262501]
synonym: "down regulation of IFN-alpha secretion" EXACT [GOC:TermGenie]
synonym: "down regulation of IFNA secretion" EXACT [GOC:TermGenie]
synonym: "down regulation of interferon-alpha secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of IFN-alpha secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of IFNA secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of interferon-alpha secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of IFN-alpha secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of IFNA secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of interferon-alpha secretion" EXACT [GOC:TermGenie]
synonym: "inhibition of IFN-alpha secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of IFNA secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of interferon-alpha secretion" NARROW [GOC:TermGenie]
synonym: "negative regulation of IFN-alpha secretion" EXACT [GOC:TermGenie]
synonym: "negative regulation of IFNA secretion" EXACT [GOC:TermGenie]
is_a: GO:0032687 ! negative regulation of interferon-alpha production
is_a: GO:0050710 ! negative regulation of cytokine secretion
is_a: GO:1902739 ! regulation of interferon-alpha secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072642 ! interferon-alpha secretion
relationship: negatively_regulates GO:0072642 ! interferon-alpha secretion
created_by: mrice
creation_date: 2014-02-26T22:13:30Z

[Term]
id: GO:1902741
name: positive regulation of interferon-alpha secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of interferon-alpha secretion." [GO_REF:0000058, GOC:TermGenie, PMID:19262501]
synonym: "activation of IFN-alpha secretion" NARROW [GOC:TermGenie]
synonym: "activation of IFNA secretion" NARROW [GOC:TermGenie]
synonym: "activation of interferon-alpha secretion" NARROW [GOC:TermGenie]
synonym: "positive regulation of IFN-alpha secretion" EXACT [GOC:TermGenie]
synonym: "positive regulation of IFNA secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of IFN-alpha secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of IFNA secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of interferon-alpha secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of IFN-alpha secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of IFNA secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of interferon-alpha secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of IFN-alpha secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of IFNA secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of interferon-alpha secretion" EXACT [GOC:TermGenie]
is_a: GO:0032727 ! positive regulation of interferon-alpha production
is_a: GO:0050715 ! positive regulation of cytokine secretion
is_a: GO:1902739 ! regulation of interferon-alpha secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072642 ! interferon-alpha secretion
relationship: positively_regulates GO:0072642 ! interferon-alpha secretion
created_by: mrice
creation_date: 2014-02-26T22:13:40Z

[Term]
id: GO:1902742
name: apoptotic process involved in development
namespace: biological_process
def: "Any apoptotic process that is involved in anatomical structure development." [GO_REF:0000060, GOC:mtg_apoptosis, GOC:pg, GOC:TermGenie]
synonym: "activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "apoptotic process involved in anatomical structure development" EXACT []
synonym: "apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
is_a: GO:0006915 ! apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: part_of GO:0048856 ! anatomical structure development
relationship: part_of GO:0048856 ! anatomical structure development
created_by: pr
creation_date: 2014-02-28T13:09:43Z

[Term]
id: GO:1902743
name: regulation of lamellipodium organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lamellipodium organization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:16054028]
is_a: GO:0031344 ! regulation of cell projection organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097581 ! lamellipodium organization
relationship: regulates GO:0097581 ! lamellipodium organization
created_by: als
creation_date: 2014-02-28T16:27:30Z

[Term]
id: GO:1902744
name: negative regulation of lamellipodium organization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lamellipodium organization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:16054028]
synonym: "down regulation of lamellipodium organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of lamellipodium organization" EXACT [GOC:TermGenie]
synonym: "downregulation of lamellipodium organization" EXACT [GOC:TermGenie]
synonym: "inhibition of lamellipodium organization" NARROW [GOC:TermGenie]
is_a: GO:0031345 ! negative regulation of cell projection organization
is_a: GO:1902743 ! regulation of lamellipodium organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097581 ! lamellipodium organization
relationship: negatively_regulates GO:0097581 ! lamellipodium organization
created_by: als
creation_date: 2014-02-28T16:27:39Z

[Term]
id: GO:1902745
name: positive regulation of lamellipodium organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lamellipodium organization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:16054028]
synonym: "activation of lamellipodium organization" NARROW [GOC:TermGenie]
synonym: "up regulation of lamellipodium organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of lamellipodium organization" EXACT [GOC:TermGenie]
synonym: "upregulation of lamellipodium organization" EXACT [GOC:TermGenie]
is_a: GO:0031346 ! positive regulation of cell projection organization
is_a: GO:1902743 ! regulation of lamellipodium organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097581 ! lamellipodium organization
relationship: positively_regulates GO:0097581 ! lamellipodium organization
created_by: als
creation_date: 2014-02-28T16:27:49Z

[Term]
id: GO:1902746
name: regulation of lens fiber cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lens fiber cell differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17592637]
synonym: "regulation of lens fibre cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0030856 ! regulation of epithelial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070306 ! lens fiber cell differentiation
relationship: regulates GO:0070306 ! lens fiber cell differentiation
created_by: mr
creation_date: 2014-03-03T23:18:50Z

[Term]
id: GO:1902747
name: negative regulation of lens fiber cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lens fiber cell differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17592637]
synonym: "down regulation of lens fiber cell differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of lens fibre cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of lens fiber cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of lens fibre cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of lens fiber cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of lens fibre cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of lens fiber cell differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of lens fibre cell differentiation" NARROW [GOC:TermGenie]
synonym: "negative regulation of lens fibre cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0030857 ! negative regulation of epithelial cell differentiation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1902746 ! regulation of lens fiber cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070306 ! lens fiber cell differentiation
relationship: negatively_regulates GO:0070306 ! lens fiber cell differentiation
created_by: mr
creation_date: 2014-03-03T23:19:32Z

[Term]
id: GO:1902748
name: positive regulation of lens fiber cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lens fiber cell differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17592637]
synonym: "activation of lens fiber cell differentiation" NARROW [GOC:TermGenie]
synonym: "activation of lens fibre cell differentiation" NARROW [GOC:TermGenie]
synonym: "positive regulation of lens fibre cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of lens fiber cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of lens fibre cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of lens fiber cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of lens fibre cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of lens fiber cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of lens fibre cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0030858 ! positive regulation of epithelial cell differentiation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1902746 ! regulation of lens fiber cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070306 ! lens fiber cell differentiation
relationship: positively_regulates GO:0070306 ! lens fiber cell differentiation
created_by: mr
creation_date: 2014-03-03T23:20:12Z

[Term]
id: GO:1902749
name: regulation of cell cycle G2/M phase transition
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell cycle G2/M phase transition." [GO_REF:0000058, GOC:jl, GOC:TermGenie]
is_a: GO:1901987 ! regulation of cell cycle phase transition
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044839 ! cell cycle G2/M phase transition
relationship: regulates GO:0044839 ! cell cycle G2/M phase transition
created_by: jl
creation_date: 2014-03-05T15:38:15Z

[Term]
id: GO:1902750
name: negative regulation of cell cycle G2/M phase transition
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle G2/M phase transition." [GO_REF:0000058, GOC:jl, GOC:TermGenie]
synonym: "down regulation of cell cycle G2/M phase transition" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell cycle G2/M phase transition" EXACT [GOC:TermGenie]
synonym: "downregulation of cell cycle G2/M phase transition" EXACT [GOC:TermGenie]
synonym: "inhibition of cell cycle G2/M phase transition" NARROW [GOC:TermGenie]
is_a: GO:1901988 ! negative regulation of cell cycle phase transition
is_a: GO:1902749 ! regulation of cell cycle G2/M phase transition
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044839 ! cell cycle G2/M phase transition
relationship: negatively_regulates GO:0044839 ! cell cycle G2/M phase transition
created_by: jl
creation_date: 2014-03-05T15:38:21Z

[Term]
id: GO:1902751
name: positive regulation of cell cycle G2/M phase transition
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell cycle G2/M phase transition." [GO_REF:0000058, GOC:jl, GOC:TermGenie]
synonym: "activation of cell cycle G2/M phase transition" NARROW [GOC:TermGenie]
synonym: "up regulation of cell cycle G2/M phase transition" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell cycle G2/M phase transition" EXACT [GOC:TermGenie]
synonym: "upregulation of cell cycle G2/M phase transition" EXACT [GOC:TermGenie]
is_a: GO:1901989 ! positive regulation of cell cycle phase transition
is_a: GO:1902749 ! regulation of cell cycle G2/M phase transition
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044839 ! cell cycle G2/M phase transition
relationship: positively_regulates GO:0044839 ! cell cycle G2/M phase transition
created_by: jl
creation_date: 2014-03-05T15:38:27Z

[Term]
id: GO:1902752
name: regulation of renal amino acid absorption
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of renal amino acid absorption." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:1526373]
is_a: GO:0098801 ! regulation of renal system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990297 ! renal amino acid absorption
relationship: regulates GO:1990297 ! renal amino acid absorption
created_by: hjd
creation_date: 2014-03-05T15:43:55Z

[Term]
id: GO:1902753
name: negative regulation of renal amino acid absorption
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of renal amino acid absorption." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:1526373]
synonym: "down regulation of renal amino acid absorption" EXACT [GOC:TermGenie]
synonym: "down-regulation of renal amino acid absorption" EXACT [GOC:TermGenie]
synonym: "downregulation of renal amino acid absorption" EXACT [GOC:TermGenie]
synonym: "inhibition of renal amino acid absorption" NARROW [GOC:TermGenie]
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1902752 ! regulation of renal amino acid absorption
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990297 ! renal amino acid absorption
relationship: negatively_regulates GO:1990297 ! renal amino acid absorption
created_by: hjd
creation_date: 2014-03-05T15:44:01Z

[Term]
id: GO:1902754
name: positive regulation of renal amino acid absorption
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of renal amino acid absorption." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:1526373]
synonym: "activation of renal amino acid absorption" NARROW [GOC:TermGenie]
synonym: "up regulation of renal amino acid absorption" EXACT [GOC:TermGenie]
synonym: "up-regulation of renal amino acid absorption" EXACT [GOC:TermGenie]
synonym: "upregulation of renal amino acid absorption" EXACT [GOC:TermGenie]
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1902752 ! regulation of renal amino acid absorption
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990297 ! renal amino acid absorption
relationship: positively_regulates GO:1990297 ! renal amino acid absorption
created_by: hjd
creation_date: 2014-03-05T15:44:07Z

[Term]
id: GO:1902755
name: sulfurated eukaryotic molybdenum cofactor(2-) metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sulfurated eukaryotic molybdenum cofactor(2-)." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:18258600]
synonym: "sulfurated eukaryotic molybdenum cofactor(2-) metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019720 ! Mo-molybdopterin cofactor metabolic process
created_by: dph
creation_date: 2014-03-05T23:29:13Z

[Term]
id: GO:1902756
name: sulfurated eukaryotic molybdenum cofactor(2-) biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sulfurated eukaryotic molybdenum cofactor(2-)." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:18258600]
synonym: "sulfurated eukaryotic molybdenum cofactor(2-) anabolism" EXACT [GOC:TermGenie]
synonym: "sulfurated eukaryotic molybdenum cofactor(2-) biosynthesis" EXACT [GOC:TermGenie]
synonym: "sulfurated eukaryotic molybdenum cofactor(2-) formation" EXACT [GOC:TermGenie]
synonym: "sulfurated eukaryotic molybdenum cofactor(2-) synthesis" EXACT [GOC:TermGenie]
xref: MetaCyc:PWY-6476
xref: Reactome:R-HSA-947581
is_a: GO:0006777 ! Mo-molybdopterin cofactor biosynthetic process
is_a: GO:1902755 ! sulfurated eukaryotic molybdenum cofactor(2-) metabolic process
relationship: has_part GO:0008265 ! Mo-molybdopterin cofactor sulfurase activity
created_by: dph
creation_date: 2014-03-05T23:29:20Z

[Term]
id: GO:1902757
name: bis(molybdopterin guanine dinucleotide)molybdenum metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving bis(molybdopterin guanine dinucleotide)molybdenum." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:23201473]
synonym: "bis(molybdopterin guanine dinucleotide)molybdenum metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009117 ! nucleotide metabolic process
is_a: GO:0019720 ! Mo-molybdopterin cofactor metabolic process
created_by: dph
creation_date: 2014-03-06T13:58:10Z

[Term]
id: GO:1902758
name: bis(molybdopterin guanine dinucleotide)molybdenum biosynthetic process
namespace: biological_process
alt_id: GO:0061600
def: "The chemical reactions and pathways resulting in the formation of bis(molybdopterin guanine dinucleotide)molybdenum." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:23201473]
synonym: "bis(molybdopterin guanine dinucleotide)molybdenum anabolism" EXACT [GOC:TermGenie]
synonym: "bis(molybdopterin guanine dinucleotide)molybdenum biosynthesis" EXACT [GOC:TermGenie]
synonym: "bis(molybdopterin guanine dinucleotide)molybdenum formation" EXACT [GOC:TermGenie]
synonym: "bis(molybdopterin guanine dinucleotide)molybdenum synthesis" EXACT [GOC:TermGenie]
synonym: "bis-Mo-molybdopterin-guanine dinucleotide cofactor biosynthetic process" EXACT []
xref: MetaCyc:PWY-5964
is_a: GO:0006777 ! Mo-molybdopterin cofactor biosynthetic process
is_a: GO:0009165 ! nucleotide biosynthetic process
is_a: GO:1902757 ! bis(molybdopterin guanine dinucleotide)molybdenum metabolic process
relationship: has_part GO:0061603 ! molybdenum cofactor guanylyltransferase activity
created_by: dph
creation_date: 2014-03-06T13:58:18Z

[Term]
id: GO:1902759
name: Mo(VI)-molybdopterin cytosine dinucleotide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving Mo(VI)-molybdopterin cytosine dinucleotide." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:23201473]
synonym: "Mo(VI)-molybdopterin cytosine dinucleotide metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009117 ! nucleotide metabolic process
is_a: GO:0019720 ! Mo-molybdopterin cofactor metabolic process
created_by: dph
creation_date: 2014-03-06T14:00:31Z

[Term]
id: GO:1902760
name: Mo(VI)-molybdopterin cytosine dinucleotide biosynthetic process
namespace: biological_process
alt_id: GO:0061601
def: "The chemical reactions and pathways resulting in the formation of Mo(VI)-molybdopterin cytosine dinucleotide." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:23201473]
synonym: "Mo(VI)-molybdopterin cytosine dinucleotide anabolism" EXACT [GOC:TermGenie]
synonym: "Mo(VI)-molybdopterin cytosine dinucleotide biosynthesis" EXACT [GOC:TermGenie]
synonym: "Mo(VI)-molybdopterin cytosine dinucleotide formation" EXACT [GOC:TermGenie]
synonym: "Mo(VI)-molybdopterin cytosine dinucleotide synthesis" EXACT [GOC:TermGenie]
synonym: "Mo-molybdopterin-cytosine-dinucleotide cofactor biosynthetic process" EXACT []
xref: MetaCyc:PWY-6476
is_a: GO:0006777 ! Mo-molybdopterin cofactor biosynthetic process
is_a: GO:0009165 ! nucleotide biosynthetic process
is_a: GO:1902759 ! Mo(VI)-molybdopterin cytosine dinucleotide metabolic process
relationship: has_part GO:0061602 ! molybdenum cofactor cytidylyltransferase activity
created_by: dph
creation_date: 2014-03-06T14:00:43Z

[Term]
id: GO:1902761
name: positive regulation of chondrocyte development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chondrocyte development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16575901]
synonym: "activation of chondrocyte development" NARROW [GOC:TermGenie]
synonym: "up regulation of chondrocyte development" EXACT [GOC:TermGenie]
synonym: "up-regulation of chondrocyte development" EXACT [GOC:TermGenie]
synonym: "upregulation of chondrocyte development" EXACT [GOC:TermGenie]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0032332 ! positive regulation of chondrocyte differentiation
is_a: GO:0061181 ! regulation of chondrocyte development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002063 ! chondrocyte development
relationship: positively_regulates GO:0002063 ! chondrocyte development
created_by: mr
creation_date: 2014-03-07T17:45:55Z

[Term]
id: GO:1902762
name: regulation of embryonic skeletal joint development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of embryonic skeletal joint development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16575901]
is_a: GO:0045995 ! regulation of embryonic development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072498 ! embryonic skeletal joint development
relationship: regulates GO:0072498 ! embryonic skeletal joint development
created_by: mr
creation_date: 2014-03-07T17:46:01Z

[Term]
id: GO:1902763
name: negative regulation of embryonic skeletal joint development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of embryonic skeletal joint development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16575901]
synonym: "down regulation of embryonic skeletal joint development" EXACT [GOC:TermGenie]
synonym: "down-regulation of embryonic skeletal joint development" EXACT [GOC:TermGenie]
synonym: "downregulation of embryonic skeletal joint development" EXACT [GOC:TermGenie]
synonym: "inhibition of embryonic skeletal joint development" NARROW [GOC:TermGenie]
is_a: GO:0045992 ! negative regulation of embryonic development
is_a: GO:1902762 ! regulation of embryonic skeletal joint development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072498 ! embryonic skeletal joint development
relationship: negatively_regulates GO:0072498 ! embryonic skeletal joint development
created_by: mr
creation_date: 2014-03-07T17:46:07Z

[Term]
id: GO:1902764
name: positive regulation of embryonic skeletal joint development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of embryonic skeletal joint development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16575901]
synonym: "activation of embryonic skeletal joint development" NARROW [GOC:TermGenie]
synonym: "up regulation of embryonic skeletal joint development" EXACT [GOC:TermGenie]
synonym: "up-regulation of embryonic skeletal joint development" EXACT [GOC:TermGenie]
synonym: "upregulation of embryonic skeletal joint development" EXACT [GOC:TermGenie]
is_a: GO:0040019 ! positive regulation of embryonic development
is_a: GO:1902762 ! regulation of embryonic skeletal joint development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072498 ! embryonic skeletal joint development
relationship: positively_regulates GO:0072498 ! embryonic skeletal joint development
created_by: mr
creation_date: 2014-03-07T17:46:13Z

[Term]
id: GO:1902765
name: L-arginine import into cell
namespace: biological_process
def: "The directed movement of L-arginine from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [GO_REF:0000075, GOC:TermGenie, PMID:10617635]
is_a: GO:0043091 ! L-arginine import
is_a: GO:1902837 ! amino acid import into cell
created_by: mah
creation_date: 2014-03-10T10:26:31Z

[Term]
id: GO:1902766
name: skeletal muscle satellite cell migration
namespace: biological_process
def: "The orderly movement of a skeletal muscle satellite cell from one site to another. Migration of these cells is a key step in the process of growth and repair of skeletal muscle cells." [GO_REF:0000091, GOC:mr, GOC:TermGenie, PMID:17996437, PMID:19609936]
is_a: GO:0016477 ! cell migration
created_by: mr
creation_date: 2014-03-10T15:20:28Z

[Term]
id: GO:1902767
name: isoprenoid biosynthetic process via mevalonate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of isoprenoid via mevalonate." [GO_REF:0000092, GOC:mengo_curators, GOC:TermGenie, PMID:11078528]
synonym: "isoprenoid anabolism via mevalonate" EXACT [GOC:TermGenie]
synonym: "isoprenoid biosynthesis via mevalonate" EXACT [GOC:TermGenie]
synonym: "isoprenoid formation via mevalonate" EXACT [GOC:TermGenie]
synonym: "isoprenoid synthesis via mevalonate" EXACT [GOC:TermGenie]
is_a: GO:0008299 ! isoprenoid biosynthetic process
created_by: tt
creation_date: 2014-03-10T23:45:10Z

[Term]
id: GO:1902768
name: isoprenoid biosynthetic process via 1-deoxy-D-xylulose 5-phosphate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of isoprenoid via 1-deoxy-D-xylulose 5-phosphate." [GO_REF:0000092, GOC:mengo_curators, GOC:TermGenie, PMID:23746261]
synonym: "isoprenoid anabolism via 1-deoxy-D-xylulose 5-phosphate" EXACT [GOC:TermGenie]
synonym: "isoprenoid biosynthesis via 1-deoxy-D-xylulose 5-phosphate" EXACT [GOC:TermGenie]
synonym: "isoprenoid formation via 1-deoxy-D-xylulose 5-phosphate" EXACT [GOC:TermGenie]
synonym: "isoprenoid synthesis via 1-deoxy-D-xylulose 5-phosphate" EXACT [GOC:TermGenie]
is_a: GO:0008299 ! isoprenoid biosynthetic process
created_by: tt
creation_date: 2014-03-11T00:09:55Z

[Term]
id: GO:1902769
name: regulation of choline O-acetyltransferase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of choline O-acetyltransferase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:7576634]
synonym: "regulation of acetyl-CoA:choline O-acetyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of CHOACTase activity" EXACT [GOC:TermGenie]
synonym: "regulation of choline acetylase activity" EXACT [GOC:TermGenie]
synonym: "regulation of choline acetyltransferase activity" EXACT [GOC:TermGenie]
is_a: GO:0051338 ! regulation of transferase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004102 ! choline O-acetyltransferase activity
relationship: regulates GO:0004102 ! choline O-acetyltransferase activity
created_by: mr
creation_date: 2014-03-11T18:54:26Z

[Term]
id: GO:1902770
name: negative regulation of choline O-acetyltransferase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of choline O-acetyltransferase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:7576634]
synonym: "down regulation of acetyl-CoA:choline O-acetyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of CHOACTase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of choline acetylase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of choline acetyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of choline O-acetyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of acetyl-CoA:choline O-acetyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of CHOACTase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of choline acetylase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of choline acetyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of choline O-acetyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of acetyl-CoA:choline O-acetyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of CHOACTase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of choline acetylase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of choline acetyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of choline O-acetyltransferase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of acetyl-CoA:choline O-acetyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of CHOACTase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of choline acetylase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of choline acetyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of choline O-acetyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of acetyl-CoA:choline O-acetyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of CHOACTase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of choline acetylase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of choline acetyltransferase activity" EXACT [GOC:TermGenie]
is_a: GO:0051348 ! negative regulation of transferase activity
is_a: GO:1902769 ! regulation of choline O-acetyltransferase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004102 ! choline O-acetyltransferase activity
relationship: negatively_regulates GO:0004102 ! choline O-acetyltransferase activity
created_by: mr
creation_date: 2014-03-11T18:56:50Z

[Term]
id: GO:1902771
name: positive regulation of choline O-acetyltransferase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of choline O-acetyltransferase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:7576634]
synonym: "activation of acetyl-CoA:choline O-acetyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of CHOACTase activity" NARROW [GOC:TermGenie]
synonym: "activation of choline acetylase activity" NARROW [GOC:TermGenie]
synonym: "activation of choline acetyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of choline O-acetyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of acetyl-CoA:choline O-acetyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of CHOACTase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of choline acetylase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of choline acetyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of acetyl-CoA:choline O-acetyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of CHOACTase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of choline acetylase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of choline acetyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of choline O-acetyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of acetyl-CoA:choline O-acetyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of CHOACTase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of choline acetylase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of choline acetyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of choline O-acetyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of acetyl-CoA:choline O-acetyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of CHOACTase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of choline acetylase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of choline acetyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of choline O-acetyltransferase activity" EXACT [GOC:TermGenie]
is_a: GO:0051347 ! positive regulation of transferase activity
is_a: GO:1902769 ! regulation of choline O-acetyltransferase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004102 ! choline O-acetyltransferase activity
relationship: positively_regulates GO:0004102 ! choline O-acetyltransferase activity
created_by: mr
creation_date: 2014-03-11T18:58:39Z

[Term]
id: GO:1902772
name: positive regulation of phosphorelay signal transduction system involved in hydrogen peroxide mediated signaling pathway
namespace: biological_process
def: "Any positive regulation of phosphorelay signal transduction system that is involved in hydrogen peroxide mediated signaling pathway." [GO_REF:0000060, GOC:TermGenie, PMID:18406331]
synonym: "activation of two-component signal transduction involved in H2O2 mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of two-component signal transduction involved in hydrogen peroxide mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of two-component signal transduction involved in hydrogen peroxide mediated signalling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of histidyl-aspartyl phosphorelay involved in H2O2 mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of histidyl-aspartyl phosphorelay involved in hydrogen peroxide mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of histidyl-aspartyl phosphorelay involved in hydrogen peroxide mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphorelay signal transduction system involved in H2O2 mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphorelay signal transduction system involved in hydrogen peroxide mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of two-component signal transduction system (phosphorelay) involved in H2O2 mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of two-component signal transduction system (phosphorelay) involved in hydrogen peroxide mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of two-component signal transduction system (phosphorelay) involved in hydrogen peroxide mediated signalling pathway" NARROW [GOC:TermGenie]
synonym: "stimulation of two-component signal transduction involved in H2O2 mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "stimulation of two-component signal transduction involved in hydrogen peroxide mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "stimulation of two-component signal transduction involved in hydrogen peroxide mediated signalling pathway" NARROW [GOC:TermGenie]
synonym: "up regulation of two-component signal transduction involved in H2O2 mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of two-component signal transduction involved in hydrogen peroxide mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of two-component signal transduction involved in hydrogen peroxide mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of two-component signal transduction involved in H2O2 mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of two-component signal transduction involved in hydrogen peroxide mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of two-component signal transduction involved in hydrogen peroxide mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of two-component signal transduction involved in H2O2 mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of two-component signal transduction involved in hydrogen peroxide mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of two-component signal transduction involved in hydrogen peroxide mediated signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0070299 ! positive regulation of phosphorelay signal transduction system
intersection_of: GO:0070299 ! positive regulation of phosphorelay signal transduction system
intersection_of: part_of GO:0071588 ! hydrogen peroxide mediated signaling pathway
relationship: part_of GO:0071588 ! hydrogen peroxide mediated signaling pathway
created_by: al
creation_date: 2014-03-17T11:42:08Z

[Term]
id: GO:1902773
name: GTPase activator complex
namespace: cellular_component
def: "A protein complex which is capable of GTPase activator activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:16449187]
comment: An example of this is BFA1 in Saccharomyces cerevisiae (P47113) in PMID:16449187 (inferred from direct assay).
is_a: GO:0043234 ! protein complex
created_by: bhm
creation_date: 2014-03-17T14:26:08Z

[Term]
id: GO:1902774
name: late endosome to lysosome transport
namespace: biological_process
def: "The directed movement of substances from late endosome to lysosome." [GO_REF:0000076, GOC:TermGenie, PMID:23949442]
comment: an example of this is snapin in mouse (Q9Z266) in PMID:20920792 inferred from mutant phenotype
synonym: "prevacuolar compartment to lysosome transport" BROAD [GOC:TermGenie]
is_a: GO:0008333 ! endosome to lysosome transport
is_a: GO:0045324 ! late endosome to vacuole transport
created_by: pad
creation_date: 2014-03-17T16:32:36Z

[Term]
id: GO:1902775
name: mitochondrial large ribosomal subunit assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a mitochondrial large ribosomal subunit." [GO_REF:0000079, GOC:TermGenie, PMID:24206665]
synonym: "39S ribosomal subunit, mitochondrial assembly" NARROW [GOC:TermGenie]
synonym: "39S ribosomal subunit, mitochondrial formation" NARROW [GOC:TermGenie]
synonym: "mitochondrial large ribosomal subunit formation" EXACT [GOC:TermGenie]
is_a: GO:0000027 ! ribosomal large subunit assembly
relationship: part_of GO:0061668 ! mitochondrial ribosome assembly
created_by: mcc
creation_date: 2014-03-18T14:32:19Z

[Term]
id: GO:1902776
name: 6-sulfoquinovose(1-) metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 6-sulfoquinovose(1-)." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:24463506]
synonym: "6-sulfoquinovose(1-) metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0071704 ! organic substance metabolic process
created_by: dph
creation_date: 2014-03-18T17:45:56Z

[Term]
id: GO:1902777
name: 6-sulfoquinovose(1-) catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 6-sulfoquinovose(1-)." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:24463506]
synonym: "6-sulfoquinovose(1-) breakdown" EXACT [GOC:TermGenie]
synonym: "6-sulfoquinovose(1-) catabolism" EXACT [GOC:TermGenie]
synonym: "6-sulfoquinovose(1-) degradation" EXACT [GOC:TermGenie]
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:1901575 ! organic substance catabolic process
is_a: GO:1902776 ! 6-sulfoquinovose(1-) metabolic process
created_by: dph
creation_date: 2014-03-18T17:46:03Z

[Term]
id: GO:1902778
name: response to alkane
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkane stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:22958739, PMID:23826995]
is_a: GO:0010033 ! response to organic substance
created_by: tt
creation_date: 2014-03-21T03:17:21Z

[Term]
id: GO:1902779
name: cellular response to alkane
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkane stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:22958739, PMID:23826995]
is_a: GO:0070887 ! cellular response to chemical stimulus
is_a: GO:1902778 ! response to alkane
created_by: tt
creation_date: 2014-03-21T03:18:04Z

[Term]
id: GO:1902780
name: response to nonane
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nonane stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:22958739]
is_a: GO:1902778 ! response to alkane
created_by: tt
creation_date: 2014-03-21T03:24:50Z

[Term]
id: GO:1902781
name: cellular response to nonane
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nonane stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:22958739]
is_a: GO:1902779 ! cellular response to alkane
is_a: GO:1902780 ! response to nonane
created_by: tt
creation_date: 2014-03-21T03:25:32Z

[Term]
id: GO:1902782
name: response to decane
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a decane stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:23826995]
is_a: GO:1902778 ! response to alkane
created_by: tt
creation_date: 2014-03-21T12:50:08Z

[Term]
id: GO:1902783
name: cellular response to decane
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a decane stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:23826995]
is_a: GO:1902779 ! cellular response to alkane
is_a: GO:1902782 ! response to decane
created_by: tt
creation_date: 2014-03-21T12:50:14Z

[Term]
id: GO:1902784
name: response to undecane
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an undecane stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:23826995]
is_a: GO:1902778 ! response to alkane
created_by: tt
creation_date: 2014-03-21T13:39:06Z

[Term]
id: GO:1902785
name: cellular response to undecane
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an undecane stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:23826995]
is_a: GO:1902779 ! cellular response to alkane
is_a: GO:1902784 ! response to undecane
created_by: tt
creation_date: 2014-03-21T13:39:24Z

[Term]
id: GO:1902786
name: response to dodecane
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dodecane stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:23826995]
is_a: GO:1902778 ! response to alkane
created_by: tt
creation_date: 2014-03-21T13:41:36Z

[Term]
id: GO:1902787
name: cellular response to dodecane
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dodecane stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:23826995]
is_a: GO:1902779 ! cellular response to alkane
is_a: GO:1902786 ! response to dodecane
created_by: tt
creation_date: 2014-03-21T13:41:52Z

[Term]
id: GO:1902788
name: response to isooctane
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isooctane stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:22328008]
is_a: GO:1902778 ! response to alkane
created_by: tt
creation_date: 2014-03-21T20:52:51Z

[Term]
id: GO:1902789
name: cellular response to isooctane
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isooctane stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:22328008]
is_a: GO:1902779 ! cellular response to alkane
is_a: GO:1902788 ! response to isooctane
created_by: tt
creation_date: 2014-03-21T20:52:58Z

[Term]
id: GO:1902790
name: undecan-2-one metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving undecan-2-one." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:4950559]
synonym: "undecan-2-one metabolism" EXACT [GOC:TermGenie]
is_a: GO:0042180 ! cellular ketone metabolic process
created_by: tt
creation_date: 2014-03-22T02:13:01Z

[Term]
id: GO:1902791
name: undecan-2-one biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of undecan-2-one." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:4950559]
synonym: "undecan-2-one anabolism" EXACT [GOC:TermGenie]
synonym: "undecan-2-one biosynthesis" EXACT [GOC:TermGenie]
synonym: "undecan-2-one formation" EXACT [GOC:TermGenie]
synonym: "undecan-2-one synthesis" EXACT [GOC:TermGenie]
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:1902790 ! undecan-2-one metabolic process
created_by: tt
creation_date: 2014-03-22T02:13:07Z

[Term]
id: GO:1902792
name: pyrroline-5-carboxylate reductase complex
namespace: cellular_component
def: "A protein complex which is capable of pyrroline-5-carboxylate reductase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:2722838]
comment: An example of this is PYCR1 in human (P32322) in PMID:2722838 (inferred from direct assay).
is_a: GO:1990204 ! oxidoreductase complex
created_by: bhm
creation_date: 2014-03-24T09:55:22Z

[Term]
id: GO:1902793
name: glutamate decarboxylase complex
namespace: cellular_component
def: "A protein complex which is capable of glutamate decarboxylase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:17384644]
comment: An example of this is GAD1 in human (Q99259) in PMID:17384644 (inferred from direct assay).
is_a: GO:1902494 ! catalytic complex
created_by: bhm
creation_date: 2014-03-24T10:59:45Z

[Term]
id: GO:1902794
name: heterochromatin island assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a heterochromatin island." [GO_REF:0000079, GOC:TermGenie, PMID:24210919]
synonym: "heterochromatin island formation" EXACT [GOC:TermGenie]
is_a: GO:0031507 ! heterochromatin assembly
created_by: mah
creation_date: 2014-03-24T12:46:49Z

[Term]
id: GO:1902795
name: heterochromatin domain assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a heterochromatin domain." [GO_REF:0000079, GOC:TermGenie, PMID:24210919]
synonym: "heterochromatin domain formation" EXACT [GOC:TermGenie]
synonym: "HOOD assembly" EXACT [GOC:TermGenie]
synonym: "HOOD formation" EXACT [GOC:TermGenie]
is_a: GO:0031507 ! heterochromatin assembly
created_by: mah
creation_date: 2014-03-24T12:46:56Z

[Term]
id: GO:1902796
name: regulation of snoRNA processing
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of snoRNA processing." [GO_REF:0000058, GOC:TermGenie, PMID:24210919]
is_a: GO:0010468 ! regulation of gene expression
is_a: GO:1903323 ! regulation of snoRNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043144 ! snoRNA processing
relationship: regulates GO:0043144 ! snoRNA processing
created_by: mah
creation_date: 2014-03-24T12:47:02Z

[Term]
id: GO:1902797
name: negative regulation of snoRNA processing
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of snoRNA processing." [GO_REF:0000058, GOC:TermGenie, PMID:24210919]
synonym: "down regulation of snoRNA processing" EXACT [GOC:TermGenie]
synonym: "down-regulation of snoRNA processing" EXACT [GOC:TermGenie]
synonym: "downregulation of snoRNA processing" EXACT [GOC:TermGenie]
synonym: "inhibition of snoRNA processing" NARROW [GOC:TermGenie]
is_a: GO:0010629 ! negative regulation of gene expression
is_a: GO:1902796 ! regulation of snoRNA processing
is_a: GO:1903324 ! negative regulation of snoRNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043144 ! snoRNA processing
relationship: negatively_regulates GO:0043144 ! snoRNA processing
created_by: mah
creation_date: 2014-03-24T12:47:08Z

[Term]
id: GO:1902798
name: positive regulation of snoRNA processing
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of snoRNA processing." [GO_REF:0000058, GOC:TermGenie, PMID:24210919]
synonym: "activation of snoRNA processing" NARROW [GOC:TermGenie]
synonym: "up regulation of snoRNA processing" EXACT [GOC:TermGenie]
synonym: "up-regulation of snoRNA processing" EXACT [GOC:TermGenie]
synonym: "upregulation of snoRNA processing" EXACT [GOC:TermGenie]
is_a: GO:0010628 ! positive regulation of gene expression
is_a: GO:1902796 ! regulation of snoRNA processing
is_a: GO:1903325 ! positive regulation of snoRNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043144 ! snoRNA processing
relationship: positively_regulates GO:0043144 ! snoRNA processing
created_by: mah
creation_date: 2014-03-24T12:47:20Z

[Term]
id: GO:1902799
name: regulation of phosphodiesterase I activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phosphodiesterase I activity." [GO_REF:0000059, GOC:TermGenie, PMID:24559510]
synonym: "regulation of 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity" EXACT [GOC:TermGenie]
synonym: "regulation of 5'-exonuclease activity" RELATED [GOC:TermGenie]
synonym: "regulation of 5'-NPDase activity" RELATED [GOC:TermGenie]
synonym: "regulation of 5'-nucleotide phosphodiesterase activity" RELATED [GOC:TermGenie]
synonym: "regulation of 5'-PDase activity" RELATED [GOC:TermGenie]
synonym: "regulation of 5'-PDE activity" RELATED [GOC:TermGenie]
synonym: "regulation of 5'-phosphodiesterase activity" RELATED [GOC:TermGenie]
synonym: "regulation of 5'NPDE activity" RELATED [GOC:TermGenie]
synonym: "regulation of alkaline phosphodiesterase activity" RELATED [GOC:TermGenie]
synonym: "regulation of exonuclease I activity" RELATED [GOC:TermGenie]
synonym: "regulation of nucleotide pyrophosphatase/phosphodiesterase I activity" EXACT [GOC:TermGenie]
synonym: "regulation of oligonucleate 5'-nucleotidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "regulation of orthophosphoric diester phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "regulation of PDE I activity" EXACT [GOC:TermGenie]
synonym: "regulation of phosphodiesterase activity" BROAD [GOC:TermGenie]
is_a: GO:0032069 ! regulation of nuclease activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004528 ! phosphodiesterase I activity
relationship: regulates GO:0004528 ! phosphodiesterase I activity
created_by: al
creation_date: 2014-03-25T08:55:48Z

[Term]
id: GO:1902800
name: positive regulation of phosphodiesterase I activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phosphodiesterase I activity." [GO_REF:0000059, GOC:TermGenie, PMID:24559510]
synonym: "activation of 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity" NARROW [GOC:TermGenie]
synonym: "activation of 5'-exonuclease activity" RELATED [GOC:TermGenie]
synonym: "activation of 5'-NPDase activity" RELATED [GOC:TermGenie]
synonym: "activation of 5'-nucleotide phosphodiesterase activity" RELATED [GOC:TermGenie]
synonym: "activation of 5'-PDase activity" RELATED [GOC:TermGenie]
synonym: "activation of 5'-PDE activity" RELATED [GOC:TermGenie]
synonym: "activation of 5'-phosphodiesterase activity" RELATED [GOC:TermGenie]
synonym: "activation of 5'NPDE activity" RELATED [GOC:TermGenie]
synonym: "activation of alkaline phosphodiesterase activity" RELATED [GOC:TermGenie]
synonym: "activation of exonuclease I activity" RELATED [GOC:TermGenie]
synonym: "activation of nucleotide pyrophosphatase/phosphodiesterase I activity" NARROW [GOC:TermGenie]
synonym: "activation of oligonucleate 5'-nucleotidohydrolase activity" NARROW [GOC:TermGenie]
synonym: "activation of orthophosphoric diester phosphohydrolase activity" NARROW [GOC:TermGenie]
synonym: "activation of PDE I activity" NARROW [GOC:TermGenie]
synonym: "activation of phosphodiesterase I activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of 5'-exonuclease activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of 5'-NPDase activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of 5'-nucleotide phosphodiesterase activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of 5'-PDase activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of 5'-PDE activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of 5'-phosphodiesterase activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of 5'NPDE activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of alkaline phosphodiesterase activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of exonuclease I activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of nucleotide pyrophosphatase/phosphodiesterase I activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of oligonucleate 5'-nucleotidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of orthophosphoric diester phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of PDE I activity" EXACT [GOC:TermGenie]
synonym: "up regulation of 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity" EXACT [GOC:TermGenie]
synonym: "up regulation of 5'-exonuclease activity" RELATED [GOC:TermGenie]
synonym: "up regulation of 5'-NPDase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of 5'-nucleotide phosphodiesterase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of 5'-PDase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of 5'-PDE activity" RELATED [GOC:TermGenie]
synonym: "up regulation of 5'-phosphodiesterase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of 5'NPDE activity" RELATED [GOC:TermGenie]
synonym: "up regulation of alkaline phosphodiesterase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of exonuclease I activity" RELATED [GOC:TermGenie]
synonym: "up regulation of nucleotide pyrophosphatase/phosphodiesterase I activity" EXACT [GOC:TermGenie]
synonym: "up regulation of oligonucleate 5'-nucleotidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of orthophosphoric diester phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of PDE I activity" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphodiesterase I activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of 5'-exonuclease activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of 5'-NPDase activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of 5'-nucleotide phosphodiesterase activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of 5'-PDase activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of 5'-PDE activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of 5'-phosphodiesterase activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of 5'NPDE activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of alkaline phosphodiesterase activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of exonuclease I activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of nucleotide pyrophosphatase/phosphodiesterase I activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of oligonucleate 5'-nucleotidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of orthophosphoric diester phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of PDE I activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphodiesterase I activity" EXACT [GOC:TermGenie]
synonym: "upregulation of 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity" EXACT [GOC:TermGenie]
synonym: "upregulation of 5'-exonuclease activity" RELATED [GOC:TermGenie]
synonym: "upregulation of 5'-NPDase activity" RELATED [GOC:TermGenie]
synonym: "upregulation of 5'-nucleotide phosphodiesterase activity" RELATED [GOC:TermGenie]
synonym: "upregulation of 5'-PDase activity" RELATED [GOC:TermGenie]
synonym: "upregulation of 5'-PDE activity" RELATED [GOC:TermGenie]
synonym: "upregulation of 5'-phosphodiesterase activity" RELATED [GOC:TermGenie]
synonym: "upregulation of 5'NPDE activity" RELATED [GOC:TermGenie]
synonym: "upregulation of alkaline phosphodiesterase activity" RELATED [GOC:TermGenie]
synonym: "upregulation of exonuclease I activity" RELATED [GOC:TermGenie]
synonym: "upregulation of nucleotide pyrophosphatase/phosphodiesterase I activity" EXACT [GOC:TermGenie]
synonym: "upregulation of oligonucleate 5'-nucleotidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of orthophosphoric diester phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of PDE I activity" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphodiesterase I activity" EXACT [GOC:TermGenie]
is_a: GO:0032075 ! positive regulation of nuclease activity
is_a: GO:1902799 ! regulation of phosphodiesterase I activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004528 ! phosphodiesterase I activity
relationship: positively_regulates GO:0004528 ! phosphodiesterase I activity
created_by: al
creation_date: 2014-03-25T08:55:54Z

[Term]
id: GO:1902801
name: regulation of heterochromatin island assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of heterochromatin island assembly." [GO_REF:0000058, GOC:TermGenie, PMID:24210919]
synonym: "regulation of heterochromatin island formation" EXACT [GOC:TermGenie]
is_a: GO:0031445 ! regulation of heterochromatin assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1902794 ! heterochromatin island assembly
relationship: regulates GO:1902794 ! heterochromatin island assembly
created_by: mah
creation_date: 2014-03-25T14:44:48Z

[Term]
id: GO:1902802
name: regulation of heterochromatin domain assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of heterochromatin domain assembly." [GO_REF:0000058, GOC:TermGenie, PMID:24210919]
synonym: "regulation of heterochromatin domain formation" EXACT [GOC:TermGenie]
synonym: "regulation of HOOD assembly" EXACT [GOC:TermGenie]
synonym: "regulation of HOOD formation" EXACT [GOC:TermGenie]
is_a: GO:0031445 ! regulation of heterochromatin assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1902795 ! heterochromatin domain assembly
relationship: regulates GO:1902795 ! heterochromatin domain assembly
created_by: mah
creation_date: 2014-03-25T14:44:54Z

[Term]
id: GO:1902803
name: regulation of synaptic vesicle transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synaptic vesicle transport." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:23527112]
synonym: "regulation of synaptic vesicle fission" RELATED [GOC:TermGenie]
synonym: "regulation of synaptic vesicle fusion" RELATED [GOC:TermGenie]
is_a: GO:0060627 ! regulation of vesicle-mediated transport
is_a: GO:1903649 ! regulation of cytoplasmic transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048489 ! synaptic vesicle transport
relationship: regulates GO:0048489 ! synaptic vesicle transport
created_by: kmv
creation_date: 2014-03-25T14:56:34Z

[Term]
id: GO:1902804
name: negative regulation of synaptic vesicle transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle transport." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:23527112]
synonym: "down regulation of synaptic vesicle fission" RELATED [GOC:TermGenie]
synonym: "down regulation of synaptic vesicle fusion" RELATED [GOC:TermGenie]
synonym: "down regulation of synaptic vesicle transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of synaptic vesicle fission" RELATED [GOC:TermGenie]
synonym: "down-regulation of synaptic vesicle fusion" RELATED [GOC:TermGenie]
synonym: "down-regulation of synaptic vesicle transport" EXACT [GOC:TermGenie]
synonym: "downregulation of synaptic vesicle fission" RELATED [GOC:TermGenie]
synonym: "downregulation of synaptic vesicle fusion" RELATED [GOC:TermGenie]
synonym: "downregulation of synaptic vesicle transport" EXACT [GOC:TermGenie]
synonym: "inhibition of synaptic vesicle fission" RELATED [GOC:TermGenie]
synonym: "inhibition of synaptic vesicle fusion" RELATED [GOC:TermGenie]
synonym: "inhibition of synaptic vesicle transport" NARROW [GOC:TermGenie]
synonym: "negative regulation of synaptic vesicle fission" RELATED [GOC:TermGenie]
synonym: "negative regulation of synaptic vesicle fusion" RELATED [GOC:TermGenie]
is_a: GO:0050805 ! negative regulation of synaptic transmission
is_a: GO:1902803 ! regulation of synaptic vesicle transport
is_a: GO:1903650 ! negative regulation of cytoplasmic transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048489 ! synaptic vesicle transport
relationship: negatively_regulates GO:0048489 ! synaptic vesicle transport
created_by: kmv
creation_date: 2014-03-25T14:56:40Z

[Term]
id: GO:1902805
name: positive regulation of synaptic vesicle transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of synaptic vesicle transport." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:23527112]
synonym: "activation of synaptic vesicle fission" RELATED [GOC:TermGenie]
synonym: "activation of synaptic vesicle fusion" RELATED [GOC:TermGenie]
synonym: "activation of synaptic vesicle transport" NARROW [GOC:TermGenie]
synonym: "positive regulation of synaptic vesicle fission" RELATED [GOC:TermGenie]
synonym: "positive regulation of synaptic vesicle fusion" RELATED [GOC:TermGenie]
synonym: "up regulation of synaptic vesicle fission" RELATED [GOC:TermGenie]
synonym: "up regulation of synaptic vesicle fusion" RELATED [GOC:TermGenie]
synonym: "up regulation of synaptic vesicle transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of synaptic vesicle fission" RELATED [GOC:TermGenie]
synonym: "up-regulation of synaptic vesicle fusion" RELATED [GOC:TermGenie]
synonym: "up-regulation of synaptic vesicle transport" EXACT [GOC:TermGenie]
synonym: "upregulation of synaptic vesicle fission" RELATED [GOC:TermGenie]
synonym: "upregulation of synaptic vesicle fusion" RELATED [GOC:TermGenie]
synonym: "upregulation of synaptic vesicle transport" EXACT [GOC:TermGenie]
is_a: GO:0050806 ! positive regulation of synaptic transmission
is_a: GO:1902803 ! regulation of synaptic vesicle transport
is_a: GO:1903651 ! positive regulation of cytoplasmic transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048489 ! synaptic vesicle transport
relationship: positively_regulates GO:0048489 ! synaptic vesicle transport
created_by: kmv
creation_date: 2014-03-25T14:56:46Z

[Term]
id: GO:1902806
name: regulation of cell cycle G1/S phase transition
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell cycle G1/S phase transition." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie]
is_a: GO:1901987 ! regulation of cell cycle phase transition
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044843 ! cell cycle G1/S phase transition
relationship: regulates GO:0044843 ! cell cycle G1/S phase transition
created_by: jl
creation_date: 2014-03-26T16:36:14Z

[Term]
id: GO:1902807
name: negative regulation of cell cycle G1/S phase transition
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle G1/S phase transition." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "down regulation of cell cycle G1/S phase transition" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell cycle G1/S phase transition" EXACT [GOC:TermGenie]
synonym: "downregulation of cell cycle G1/S phase transition" EXACT [GOC:TermGenie]
synonym: "inhibition of cell cycle G1/S phase transition" NARROW [GOC:TermGenie]
is_a: GO:1901988 ! negative regulation of cell cycle phase transition
is_a: GO:1902806 ! regulation of cell cycle G1/S phase transition
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044843 ! cell cycle G1/S phase transition
relationship: negatively_regulates GO:0044843 ! cell cycle G1/S phase transition
created_by: jl
creation_date: 2014-03-26T16:36:20Z

[Term]
id: GO:1902808
name: positive regulation of cell cycle G1/S phase transition
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell cycle G1/S phase transition." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "activation of cell cycle G1/S phase transition" NARROW [GOC:TermGenie]
synonym: "up regulation of cell cycle G1/S phase transition" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell cycle G1/S phase transition" EXACT [GOC:TermGenie]
synonym: "upregulation of cell cycle G1/S phase transition" EXACT [GOC:TermGenie]
is_a: GO:1901989 ! positive regulation of cell cycle phase transition
is_a: GO:1902806 ! regulation of cell cycle G1/S phase transition
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044843 ! cell cycle G1/S phase transition
relationship: positively_regulates GO:0044843 ! cell cycle G1/S phase transition
created_by: jl
creation_date: 2014-03-26T16:36:32Z

[Term]
id: GO:1902809
name: regulation of skeletal muscle fiber differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle fiber differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17879321]
is_a: GO:0010830 ! regulation of myotube differentiation
is_a: GO:2001014 ! regulation of skeletal muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0098528 ! skeletal muscle fiber differentiation
relationship: regulates GO:0098528 ! skeletal muscle fiber differentiation
created_by: mr
creation_date: 2014-03-26T21:18:26Z

[Term]
id: GO:1902810
name: negative regulation of skeletal muscle fiber differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle fiber differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17879321]
synonym: "down regulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of skeletal muscle fiber differentiation" NARROW [GOC:TermGenie]
is_a: GO:0010832 ! negative regulation of myotube differentiation
is_a: GO:1902809 ! regulation of skeletal muscle fiber differentiation
is_a: GO:2001015 ! negative regulation of skeletal muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0098528 ! skeletal muscle fiber differentiation
relationship: negatively_regulates GO:0098528 ! skeletal muscle fiber differentiation
created_by: mr
creation_date: 2014-03-26T21:18:32Z

[Term]
id: GO:1902811
name: positive regulation of skeletal muscle fiber differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of skeletal muscle fiber differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17879321]
synonym: "activation of skeletal muscle fiber differentiation" NARROW [GOC:TermGenie]
synonym: "up regulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie]
is_a: GO:0010831 ! positive regulation of myotube differentiation
is_a: GO:1902809 ! regulation of skeletal muscle fiber differentiation
is_a: GO:2001016 ! positive regulation of skeletal muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0098528 ! skeletal muscle fiber differentiation
relationship: positively_regulates GO:0098528 ! skeletal muscle fiber differentiation
created_by: mr
creation_date: 2014-03-26T21:18:38Z

[Term]
id: GO:1902812
name: regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10499580]
synonym: "regulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT [GOC:TermGenie]
synonym: "regulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie]
is_a: GO:0030510 ! regulation of BMP signaling pathway
is_a: GO:2000026 ! regulation of multicellular organismal development
is_a: GO:2000380 ! regulation of mesoderm development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003155 ! BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry
relationship: regulates GO:0003155 ! BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry
created_by: mr
creation_date: 2014-03-26T21:18:44Z

[Term]
id: GO:1902813
name: negative regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10499580]
synonym: "down regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie]
synonym: "down regulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT [GOC:TermGenie]
synonym: "down regulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie]
synonym: "down-regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie]
synonym: "down-regulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT [GOC:TermGenie]
synonym: "down-regulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie]
synonym: "downregulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie]
synonym: "downregulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT [GOC:TermGenie]
synonym: "downregulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie]
synonym: "inhibition of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry" NARROW [GOC:TermGenie]
synonym: "inhibition of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination" NARROW [GOC:TermGenie]
synonym: "inhibition of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry" NARROW [GOC:TermGenie]
synonym: "negative regulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT [GOC:TermGenie]
synonym: "negative regulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie]
is_a: GO:0030514 ! negative regulation of BMP signaling pathway
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1902812 ! regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry
is_a: GO:2000381 ! negative regulation of mesoderm development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003155 ! BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry
relationship: negatively_regulates GO:0003155 ! BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry
created_by: mr
creation_date: 2014-03-26T21:18:50Z

[Term]
id: GO:1902814
name: positive regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10499580]
synonym: "activation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry" NARROW [GOC:TermGenie]
synonym: "activation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination" NARROW [GOC:TermGenie]
synonym: "activation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry" NARROW [GOC:TermGenie]
synonym: "positive regulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT [GOC:TermGenie]
synonym: "positive regulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie]
synonym: "up regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie]
synonym: "up regulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT [GOC:TermGenie]
synonym: "up regulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie]
synonym: "up-regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie]
synonym: "up-regulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT [GOC:TermGenie]
synonym: "up-regulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie]
synonym: "upregulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie]
synonym: "upregulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT [GOC:TermGenie]
synonym: "upregulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie]
is_a: GO:0030513 ! positive regulation of BMP signaling pathway
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1902812 ! regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry
is_a: GO:2000382 ! positive regulation of mesoderm development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003155 ! BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry
relationship: positively_regulates GO:0003155 ! BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry
created_by: mr
creation_date: 2014-03-26T21:18:56Z

[Term]
id: GO:1902815
name: N,N'-diacetylchitobiose import
namespace: biological_process
def: "The directed movement of N,N'-diacetylchitobiose into a cell or organelle." [GO_REF:0000073, GOC:am, GOC:TermGenie, PMID:9405618]
is_a: GO:1901264 ! carbohydrate derivative transport
created_by: tb
creation_date: 2014-03-27T20:58:58Z

[Term]
id: GO:1902816
name: regulation of protein localization to microtubule
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to microtubule." [GO_REF:0000058, GOC:TermGenie, GOC:vw, PMID:23087209]
synonym: "regulation of protein localisation to microtubule" EXACT [GOC:TermGenie]
is_a: GO:1903827 ! regulation of cellular protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035372 ! protein localization to microtubule
relationship: regulates GO:0035372 ! protein localization to microtubule
created_by: tb
creation_date: 2014-03-27T22:07:12Z

[Term]
id: GO:1902817
name: negative regulation of protein localization to microtubule
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to microtubule." [GO_REF:0000058, GOC:TermGenie, GOC:vw, PMID:23087209]
synonym: "down regulation of protein localisation to microtubule" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to microtubule" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation to microtubule" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to microtubule" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation to microtubule" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to microtubule" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localisation to microtubule" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to microtubule" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation to microtubule" EXACT [GOC:TermGenie]
is_a: GO:1902816 ! regulation of protein localization to microtubule
is_a: GO:1903828 ! negative regulation of cellular protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035372 ! protein localization to microtubule
relationship: negatively_regulates GO:0035372 ! protein localization to microtubule
created_by: tb
creation_date: 2014-03-27T22:07:18Z

[Term]
id: GO:1902818
name: ethyl acetate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ethyl acetate." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:16013377]
synonym: "ethyl acetate metabolism" EXACT [GOC:TermGenie]
synonym: "ethyl ethanoate metabolic process" EXACT []
is_a: GO:1900619 ! acetate ester metabolic process
created_by: tt
creation_date: 2014-03-30T20:26:47Z

[Term]
id: GO:1902819
name: ethyl acetate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ethyl acetate." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:16013377]
synonym: "ethyl acetate anabolism" EXACT [GOC:TermGenie]
synonym: "ethyl acetate biosynthesis" EXACT [GOC:TermGenie]
synonym: "ethyl acetate formation" EXACT [GOC:TermGenie]
synonym: "ethyl acetate synthesis" EXACT [GOC:TermGenie]
synonym: "ethyl ethanoate biosynthetic process" EXACT []
is_a: GO:1900620 ! acetate ester biosynthetic process
is_a: GO:1902818 ! ethyl acetate metabolic process
created_by: tt
creation_date: 2014-03-30T20:26:53Z

[Term]
id: GO:1902820
name: 1-undecene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 1-undecene." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:16013377]
synonym: "1-undecene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0043449 ! cellular alkene metabolic process
created_by: tt
creation_date: 2014-03-31T02:50:48Z

[Term]
id: GO:1902821
name: 1-undecene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 1-undecene." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:16013377]
synonym: "1-undecene anabolism" EXACT [GOC:TermGenie]
synonym: "1-undecene biosynthesis" EXACT [GOC:TermGenie]
synonym: "1-undecene formation" EXACT [GOC:TermGenie]
synonym: "1-undecene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0043450 ! alkene biosynthetic process
is_a: GO:1902820 ! 1-undecene metabolic process
created_by: tt
creation_date: 2014-03-31T02:51:19Z

[Term]
id: GO:1902822
name: regulation of late endosome to lysosome transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of late endosome to lysosome transport." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:23949442]
synonym: "regulation of prevacuolar compartment to lysosome transport" BROAD [GOC:TermGenie]
is_a: GO:1903335 ! regulation of vacuolar transport
is_a: GO:1903649 ! regulation of cytoplasmic transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1902774 ! late endosome to lysosome transport
relationship: regulates GO:1902774 ! late endosome to lysosome transport
created_by: pad
creation_date: 2014-03-31T10:08:38Z

[Term]
id: GO:1902823
name: negative regulation of late endosome to lysosome transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of late endosome to lysosome transport." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:23949442]
synonym: "down regulation of late endosome to lysosome transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of late endosome to lysosome transport" EXACT [GOC:TermGenie]
synonym: "downregulation of late endosome to lysosome transport" EXACT [GOC:TermGenie]
synonym: "inhibition of late endosome to lysosome transport" NARROW [GOC:TermGenie]
is_a: GO:1902822 ! regulation of late endosome to lysosome transport
is_a: GO:1903336 ! negative regulation of vacuolar transport
is_a: GO:1903650 ! negative regulation of cytoplasmic transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1902774 ! late endosome to lysosome transport
relationship: negatively_regulates GO:1902774 ! late endosome to lysosome transport
created_by: pad
creation_date: 2014-03-31T10:08:51Z

[Term]
id: GO:1902824
name: positive regulation of late endosome to lysosome transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of late endosome to lysosome transport." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:23949442]
synonym: "activation of late endosome to lysosome transport" NARROW [GOC:TermGenie]
synonym: "up regulation of late endosome to lysosome transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of late endosome to lysosome transport" EXACT [GOC:TermGenie]
synonym: "upregulation of late endosome to lysosome transport" EXACT [GOC:TermGenie]
is_a: GO:1902822 ! regulation of late endosome to lysosome transport
is_a: GO:1903337 ! positive regulation of vacuolar transport
is_a: GO:1903651 ! positive regulation of cytoplasmic transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1902774 ! late endosome to lysosome transport
relationship: positively_regulates GO:1902774 ! late endosome to lysosome transport
created_by: pad
creation_date: 2014-03-31T10:08:57Z

[Term]
id: GO:1902825
name: proline import into cell
namespace: biological_process
def: "The directed movement of proline from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [GO_REF:0000075, GOC:TermGenie, PMID:24344203]
is_a: GO:0015824 ! proline transport
is_a: GO:1902837 ! amino acid import into cell
created_by: mah
creation_date: 2014-03-31T13:14:04Z

[Term]
id: GO:1902826
name: regulation of L-arginine import into cell
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of L-arginine import into cell." [GO_REF:0000058, GOC:TermGenie, PMID:24344203]
is_a: GO:0010963 ! regulation of L-arginine import
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1902765 ! L-arginine import into cell
relationship: regulates GO:1902765 ! L-arginine import into cell
created_by: mah
creation_date: 2014-03-31T14:30:40Z

[Term]
id: GO:1902827
name: negative regulation of L-arginine import into cell
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of L-arginine import into cell." [GO_REF:0000058, GOC:TermGenie, PMID:24344203]
synonym: "down regulation of L-arginine import into cell" EXACT [GOC:TermGenie]
synonym: "down-regulation of L-arginine import into cell" EXACT [GOC:TermGenie]
synonym: "downregulation of L-arginine import into cell" EXACT [GOC:TermGenie]
synonym: "inhibition of L-arginine import into cell" NARROW [GOC:TermGenie]
is_a: GO:0051956 ! negative regulation of amino acid transport
is_a: GO:1902826 ! regulation of L-arginine import into cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1902765 ! L-arginine import into cell
relationship: negatively_regulates GO:1902765 ! L-arginine import into cell
created_by: mah
creation_date: 2014-03-31T14:30:46Z

[Term]
id: GO:1902828
name: positive regulation of L-arginine import into cell
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of L-arginine import into cell." [GO_REF:0000058, GOC:TermGenie, PMID:24344203]
synonym: "activation of L-arginine import into cell" NARROW [GOC:TermGenie]
synonym: "up regulation of L-arginine import into cell" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-arginine import into cell" EXACT [GOC:TermGenie]
synonym: "upregulation of L-arginine import into cell" EXACT [GOC:TermGenie]
is_a: GO:1901042 ! positive regulation of L-arginine import
is_a: GO:1902826 ! regulation of L-arginine import into cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1902765 ! L-arginine import into cell
relationship: positively_regulates GO:1902765 ! L-arginine import into cell
created_by: mah
creation_date: 2014-03-31T14:30:52Z

[Term]
id: GO:1902829
name: regulation of spinal cord association neuron differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of spinal cord association neuron differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:21730158]
synonym: "regulation of spinal cord dorsal interneuron differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045664 ! regulation of neuron differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0021527 ! spinal cord association neuron differentiation
relationship: regulates GO:0021527 ! spinal cord association neuron differentiation
created_by: mr
creation_date: 2014-03-31T17:10:55Z

[Term]
id: GO:1902830
name: negative regulation of spinal cord association neuron differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of spinal cord association neuron differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:21730158]
synonym: "down regulation of spinal cord association neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of spinal cord dorsal interneuron differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of spinal cord association neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of spinal cord dorsal interneuron differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of spinal cord association neuron differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of spinal cord dorsal interneuron differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of spinal cord association neuron differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of spinal cord dorsal interneuron differentiation" NARROW [GOC:TermGenie]
synonym: "negative regulation of spinal cord dorsal interneuron differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045665 ! negative regulation of neuron differentiation
is_a: GO:1902829 ! regulation of spinal cord association neuron differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0021527 ! spinal cord association neuron differentiation
relationship: negatively_regulates GO:0021527 ! spinal cord association neuron differentiation
created_by: mr
creation_date: 2014-03-31T17:11:55Z

[Term]
id: GO:1902831
name: positive regulation of spinal cord association neuron differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of spinal cord association neuron differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:21730158]
synonym: "activation of spinal cord association neuron differentiation" NARROW [GOC:TermGenie]
synonym: "activation of spinal cord dorsal interneuron differentiation" NARROW [GOC:TermGenie]
synonym: "positive regulation of spinal cord dorsal interneuron differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of spinal cord association neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of spinal cord dorsal interneuron differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of spinal cord association neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of spinal cord dorsal interneuron differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of spinal cord association neuron differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of spinal cord dorsal interneuron differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045666 ! positive regulation of neuron differentiation
is_a: GO:1902829 ! regulation of spinal cord association neuron differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0021527 ! spinal cord association neuron differentiation
relationship: positively_regulates GO:0021527 ! spinal cord association neuron differentiation
created_by: mr
creation_date: 2014-03-31T17:12:38Z

[Term]
id: GO:1902832
name: negative regulation of cell proliferation in dorsal spinal cord
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation in dorsal spinal cord." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:21730158]
synonym: "down regulation of cell proliferation in dorsal spinal cord" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell proliferation in dorsal spinal cord" EXACT [GOC:TermGenie]
synonym: "downregulation of cell proliferation in dorsal spinal cord" EXACT [GOC:TermGenie]
synonym: "inhibition of cell proliferation in dorsal spinal cord" NARROW [GOC:TermGenie]
is_a: GO:0021921 ! regulation of cell proliferation in dorsal spinal cord
is_a: GO:2000178 ! negative regulation of neural precursor cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010456 ! cell proliferation in dorsal spinal cord
relationship: negatively_regulates GO:0010456 ! cell proliferation in dorsal spinal cord
created_by: mr
creation_date: 2014-03-31T17:42:50Z

[Term]
id: GO:1902833
name: positive regulation of cell proliferation in dorsal spinal cord
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell proliferation in dorsal spinal cord." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:21730158]
synonym: "activation of cell proliferation in dorsal spinal cord" NARROW [GOC:TermGenie]
synonym: "up regulation of cell proliferation in dorsal spinal cord" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell proliferation in dorsal spinal cord" EXACT [GOC:TermGenie]
synonym: "upregulation of cell proliferation in dorsal spinal cord" EXACT [GOC:TermGenie]
is_a: GO:0021921 ! regulation of cell proliferation in dorsal spinal cord
is_a: GO:2000179 ! positive regulation of neural precursor cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010456 ! cell proliferation in dorsal spinal cord
relationship: positively_regulates GO:0010456 ! cell proliferation in dorsal spinal cord
created_by: mr
creation_date: 2014-03-31T17:43:33Z

[Term]
id: GO:1902834
name: regulation of proline import into cell
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of proline import into cell." [GO_REF:0000058, GOC:TermGenie, PMID:24344203]
is_a: GO:0010958 ! regulation of amino acid import
is_a: GO:0070881 ! regulation of proline transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1902825 ! proline import into cell
relationship: regulates GO:1902825 ! proline import into cell
created_by: mah
creation_date: 2014-04-01T13:44:00Z

[Term]
id: GO:1902835
name: negative regulation of proline import into cell
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of proline import into cell." [GO_REF:0000058, GOC:TermGenie, PMID:24344203]
synonym: "down regulation of proline import into cell" EXACT [GOC:TermGenie]
synonym: "down-regulation of proline import into cell" EXACT [GOC:TermGenie]
synonym: "downregulation of proline import into cell" EXACT [GOC:TermGenie]
synonym: "inhibition of proline import into cell" NARROW [GOC:TermGenie]
is_a: GO:0051956 ! negative regulation of amino acid transport
is_a: GO:1902834 ! regulation of proline import into cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1902825 ! proline import into cell
relationship: negatively_regulates GO:1902825 ! proline import into cell
created_by: mah
creation_date: 2014-04-01T13:44:06Z

[Term]
id: GO:1902836
name: positive regulation of proline import into cell
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of proline import into cell." [GO_REF:0000058, GOC:TermGenie, PMID:24344203]
synonym: "activation of proline import into cell" NARROW [GOC:TermGenie]
synonym: "up regulation of proline import into cell" EXACT [GOC:TermGenie]
synonym: "up-regulation of proline import into cell" EXACT [GOC:TermGenie]
synonym: "upregulation of proline import into cell" EXACT [GOC:TermGenie]
is_a: GO:0051957 ! positive regulation of amino acid transport
is_a: GO:1902834 ! regulation of proline import into cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1902825 ! proline import into cell
relationship: positively_regulates GO:1902825 ! proline import into cell
created_by: mah
creation_date: 2014-04-01T13:44:20Z

[Term]
id: GO:1902837
name: amino acid import into cell
namespace: biological_process
def: "The directed movement of amino acids from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [GO_REF:0000075, GOC:TermGenie, PMID:24344203]
is_a: GO:0043090 ! amino acid import
is_a: GO:0098657 ! import into cell
created_by: mah
creation_date: 2014-04-01T13:44:26Z

[Term]
id: GO:1902838
name: regulation of nuclear migration along microtubule
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nuclear migration along microtubule." [GO_REF:0000058, GOC:TermGenie, PMID:23087209]
synonym: "regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie]
synonym: "regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "regulation of nuclear movement, microtubule-mediated" BROAD [GOC:TermGenie]
synonym: "regulation of nucleus migration" BROAD [GOC:TermGenie]
synonym: "regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie]
synonym: "regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie]
is_a: GO:1902513 ! regulation of organelle transport along microtubule
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030473 ! nuclear migration along microtubule
relationship: regulates GO:0030473 ! nuclear migration along microtubule
created_by: vw
creation_date: 2014-04-01T13:50:23Z

[Term]
id: GO:1902839
name: negative regulation of nuclear migration along microtubule
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of nuclear migration along microtubule." [GO_REF:0000058, GOC:TermGenie, PMID:23087209]
synonym: "down regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "down regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "down regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "down regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "down regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie]
synonym: "down regulation of nuclear migration along microtubule" EXACT [GOC:TermGenie]
synonym: "down regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "down regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie]
synonym: "down regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "down-regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "down-regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "down-regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "down-regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "down-regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie]
synonym: "down-regulation of nuclear migration along microtubule" EXACT [GOC:TermGenie]
synonym: "down-regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "down-regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie]
synonym: "down-regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "downregulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "downregulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "downregulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "downregulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "downregulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie]
synonym: "downregulation of nuclear migration along microtubule" EXACT [GOC:TermGenie]
synonym: "downregulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "downregulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie]
synonym: "downregulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "inhibition of microtubule cytoskeleton-dependent nuclear positioning" NARROW [GOC:TermGenie]
synonym: "inhibition of microtubule cytoskeleton-dependent nucleus positioning" NARROW [GOC:TermGenie]
synonym: "inhibition of microtubule-dependent nuclear positioning" NARROW [GOC:TermGenie]
synonym: "inhibition of microtubule-dependent nucleus positioning" NARROW [GOC:TermGenie]
synonym: "inhibition of microtubule-mediated nuclear migration" NARROW [GOC:TermGenie]
synonym: "inhibition of nuclear migration along microtubule" NARROW [GOC:TermGenie]
synonym: "inhibition of nuclear migration, microtubule-mediated" NARROW [GOC:TermGenie]
synonym: "inhibition of transport of nucleus by microtubules" NARROW [GOC:TermGenie]
synonym: "inhibition of transport of nucleus, microtubule-mediated" NARROW [GOC:TermGenie]
synonym: "negative regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "negative regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "negative regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "negative regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "negative regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie]
synonym: "negative regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "negative regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie]
synonym: "negative regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie]
is_a: GO:0032387 ! negative regulation of intracellular transport
is_a: GO:0051271 ! negative regulation of cellular component movement
is_a: GO:1902838 ! regulation of nuclear migration along microtubule
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030473 ! nuclear migration along microtubule
relationship: negatively_regulates GO:0030473 ! nuclear migration along microtubule
created_by: vw
creation_date: 2014-04-01T13:50:29Z

[Term]
id: GO:1902840
name: positive regulation of nuclear migration along microtubule
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of nuclear migration along microtubule." [GO_REF:0000058, GOC:TermGenie, PMID:23087209]
synonym: "activation of microtubule cytoskeleton-dependent nuclear positioning" NARROW [GOC:TermGenie]
synonym: "activation of microtubule cytoskeleton-dependent nucleus positioning" NARROW [GOC:TermGenie]
synonym: "activation of microtubule-dependent nuclear positioning" NARROW [GOC:TermGenie]
synonym: "activation of microtubule-dependent nucleus positioning" NARROW [GOC:TermGenie]
synonym: "activation of microtubule-mediated nuclear migration" NARROW [GOC:TermGenie]
synonym: "activation of nuclear migration along microtubule" NARROW [GOC:TermGenie]
synonym: "activation of nuclear migration, microtubule-mediated" NARROW [GOC:TermGenie]
synonym: "activation of transport of nucleus by microtubules" NARROW [GOC:TermGenie]
synonym: "activation of transport of nucleus, microtubule-mediated" NARROW [GOC:TermGenie]
synonym: "positive regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "positive regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "positive regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "positive regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "positive regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie]
synonym: "positive regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "positive regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie]
synonym: "positive regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "up regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "up regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "up regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "up regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "up regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie]
synonym: "up regulation of nuclear migration along microtubule" EXACT [GOC:TermGenie]
synonym: "up regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "up regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie]
synonym: "up regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "up-regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "up-regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "up-regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "up-regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "up-regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie]
synonym: "up-regulation of nuclear migration along microtubule" EXACT [GOC:TermGenie]
synonym: "up-regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "up-regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie]
synonym: "up-regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "upregulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "upregulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "upregulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "upregulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "upregulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie]
synonym: "upregulation of nuclear migration along microtubule" EXACT [GOC:TermGenie]
synonym: "upregulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "upregulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie]
synonym: "upregulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie]
is_a: GO:0032388 ! positive regulation of intracellular transport
is_a: GO:0051272 ! positive regulation of cellular component movement
is_a: GO:1902838 ! regulation of nuclear migration along microtubule
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030473 ! nuclear migration along microtubule
relationship: positively_regulates GO:0030473 ! nuclear migration along microtubule
created_by: vw
creation_date: 2014-04-01T13:50:35Z

[Term]
id: GO:1902841
name: regulation of netrin-activated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of netrin-activated signaling pathway." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, pmid:24004945]
synonym: "regulation of netrin signaling pathway" EXACT [GOC:TermGenie]
synonym: "regulation of netrin-activated signal transduction pathway" EXACT [GOC:TermGenie]
synonym: "regulation of netrin-activated signalling pathway" EXACT [GOC:TermGenie]
synonym: "regulation of netrin-mediated signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0009966 ! regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0038007 ! netrin-activated signaling pathway
relationship: regulates GO:0038007 ! netrin-activated signaling pathway
created_by: kmv
creation_date: 2014-04-01T15:24:46Z

[Term]
id: GO:1902842
name: negative regulation of netrin-activated signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of netrin-activated signaling pathway." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, pmid:24004945]
synonym: "down regulation of netrin signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of netrin-activated signal transduction pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of netrin-activated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of netrin-activated signalling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of netrin-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of netrin signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of netrin-activated signal transduction pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of netrin-activated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of netrin-activated signalling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of netrin-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of netrin signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of netrin-activated signal transduction pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of netrin-activated signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of netrin-activated signalling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of netrin-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of netrin signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of netrin-activated signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of netrin-activated signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of netrin-activated signalling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of netrin-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of netrin signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of netrin-activated signal transduction pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of netrin-activated signalling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of netrin-mediated signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:1902841 ! regulation of netrin-activated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0038007 ! netrin-activated signaling pathway
relationship: negatively_regulates GO:0038007 ! netrin-activated signaling pathway
created_by: kmv
creation_date: 2014-04-01T15:25:33Z

[Term]
id: GO:1902843
name: positive regulation of netrin-activated signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of netrin-activated signaling pathway." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, pmid:24004945]
synonym: "activation of netrin signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of netrin-activated signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "activation of netrin-activated signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of netrin-activated signalling pathway" NARROW [GOC:TermGenie]
synonym: "activation of netrin-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of netrin signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of netrin-activated signal transduction pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of netrin-activated signalling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of netrin-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of netrin signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of netrin-activated signal transduction pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of netrin-activated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of netrin-activated signalling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of netrin-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of netrin signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of netrin-activated signal transduction pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of netrin-activated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of netrin-activated signalling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of netrin-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of netrin signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of netrin-activated signal transduction pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of netrin-activated signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of netrin-activated signalling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of netrin-mediated signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:1902841 ! regulation of netrin-activated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0038007 ! netrin-activated signaling pathway
relationship: positively_regulates GO:0038007 ! netrin-activated signaling pathway
created_by: kmv
creation_date: 2014-04-01T15:25:53Z

[Term]
id: GO:1902844
name: positive regulation of spinal cord association neuron differentiation by negative regulation of canonical Wnt signaling pathway
namespace: biological_process
def: "A negative regulation of canonical Wnt signaling pathway that results in positive regulation of spinal cord association neuron differentiation." [GO_REF:0000063, GOC:mr, GOC:TermGenie, PMID:11262869]
synonym: "activation of spinal cord association neuron differentiation by negative regulation of canonical Wnt signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of spinal cord dorsal interneuron differentiation by negative regulation of canonical Wnt signaling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of spinal cord dorsal interneuron differentiation by negative regulation of canonical Wnt signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of spinal cord association neuron differentiation by negative regulation of canonical Wnt signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of spinal cord dorsal interneuron differentiation by negative regulation of canonical Wnt signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of spinal cord association neuron differentiation by negative regulation of canonical Wnt signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of spinal cord dorsal interneuron differentiation by negative regulation of canonical Wnt signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of spinal cord association neuron differentiation by negative regulation of canonical Wnt signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of spinal cord dorsal interneuron differentiation by negative regulation of canonical Wnt signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0050768 ! negative regulation of neurogenesis
is_a: GO:0090090 ! negative regulation of canonical Wnt signaling pathway
is_a: GO:1902829 ! regulation of spinal cord association neuron differentiation
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: negatively_regulates GO:0100067 ! positive regulation of spinal cord association neuron differentiation by canonical Wnt signaling pathway
relationship: negatively_regulates GO:0100067 ! positive regulation of spinal cord association neuron differentiation by canonical Wnt signaling pathway
created_by: mr
creation_date: 2014-04-01T15:28:30Z

[Term]
id: GO:1902845
name: negative regulation of mitotic spindle elongation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic spindle elongation." [GO_REF:0000058, GOC:TermGenie, PMID:23087209]
synonym: "down regulation of mitotic spindle elongation" EXACT [GOC:TermGenie]
synonym: "down regulation of spindle elongation during mitosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitotic spindle elongation" EXACT [GOC:TermGenie]
synonym: "down-regulation of spindle elongation during mitosis" EXACT [GOC:TermGenie]
synonym: "downregulation of mitotic spindle elongation" EXACT [GOC:TermGenie]
synonym: "downregulation of spindle elongation during mitosis" EXACT [GOC:TermGenie]
synonym: "inhibition of mitotic spindle elongation" NARROW [GOC:TermGenie]
synonym: "inhibition of spindle elongation during mitosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of spindle elongation during mitosis" EXACT [GOC:TermGenie]
is_a: GO:0031117 ! positive regulation of microtubule depolymerization
is_a: GO:0032888 ! regulation of mitotic spindle elongation
is_a: GO:0033048 ! negative regulation of mitotic sister chromatid segregation
is_a: GO:0051494 ! negative regulation of cytoskeleton organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000022 ! mitotic spindle elongation
relationship: negatively_regulates GO:0000022 ! mitotic spindle elongation
created_by: vw
creation_date: 2014-04-02T08:43:28Z

[Term]
id: GO:1902846
name: positive regulation of mitotic spindle elongation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitotic spindle elongation." [GO_REF:0000058, GOC:TermGenie, PMID:23087209]
synonym: "activation of mitotic spindle elongation" NARROW [GOC:TermGenie]
synonym: "activation of spindle elongation during mitosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of spindle elongation during mitosis" EXACT [GOC:TermGenie]
synonym: "up regulation of mitotic spindle elongation" EXACT [GOC:TermGenie]
synonym: "up regulation of spindle elongation during mitosis" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitotic spindle elongation" EXACT [GOC:TermGenie]
synonym: "up-regulation of spindle elongation during mitosis" EXACT [GOC:TermGenie]
synonym: "upregulation of mitotic spindle elongation" EXACT [GOC:TermGenie]
synonym: "upregulation of spindle elongation during mitosis" EXACT [GOC:TermGenie]
is_a: GO:0032888 ! regulation of mitotic spindle elongation
is_a: GO:0045840 ! positive regulation of mitotic nuclear division
is_a: GO:0051495 ! positive regulation of cytoskeleton organization
is_a: GO:0051984 ! positive regulation of chromosome segregation
is_a: GO:2001252 ! positive regulation of chromosome organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000022 ! mitotic spindle elongation
relationship: positively_regulates GO:0000022 ! mitotic spindle elongation
created_by: vw
creation_date: 2014-04-02T08:43:34Z

[Term]
id: GO:1902847
name: regulation of neuronal signal transduction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neuronal signal transduction." [GO_REF:0000058, GOC:sjp, GOC:TermGenie]
is_a: GO:0009966 ! regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0023041 ! neuronal signal transduction
relationship: regulates GO:0023041 ! neuronal signal transduction
created_by: sjp
creation_date: 2014-04-02T10:11:12Z

[Term]
id: GO:1902848
name: negative regulation of neuronal signal transduction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuronal signal transduction." [GO_REF:0000058, GOC:sjp, GOC:TermGenie]
synonym: "down regulation of neuronal signal transduction" EXACT [GOC:TermGenie]
synonym: "down-regulation of neuronal signal transduction" EXACT [GOC:TermGenie]
synonym: "downregulation of neuronal signal transduction" EXACT [GOC:TermGenie]
synonym: "inhibition of neuronal signal transduction" NARROW [GOC:TermGenie]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:1902847 ! regulation of neuronal signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0023041 ! neuronal signal transduction
relationship: negatively_regulates GO:0023041 ! neuronal signal transduction
created_by: sjp
creation_date: 2014-04-02T10:11:18Z

[Term]
id: GO:1902849
name: positive regulation of neuronal signal transduction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neuronal signal transduction." [GO_REF:0000058, GOC:sjp, GOC:TermGenie]
synonym: "activation of neuronal signal transduction" NARROW [GOC:TermGenie]
synonym: "up regulation of neuronal signal transduction" EXACT [GOC:TermGenie]
synonym: "up-regulation of neuronal signal transduction" EXACT [GOC:TermGenie]
synonym: "upregulation of neuronal signal transduction" EXACT [GOC:TermGenie]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:1902847 ! regulation of neuronal signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0023041 ! neuronal signal transduction
relationship: positively_regulates GO:0023041 ! neuronal signal transduction
created_by: sjp
creation_date: 2014-04-02T10:11:24Z

[Term]
id: GO:1902850
name: microtubule cytoskeleton organization involved in mitosis
namespace: biological_process
def: "Any microtubule cytoskeleton organization that is involved in mitosis." [GO_REF:0000060, GOC:TermGenie, PMID:18799626]
synonym: "microtubule cytoskeleton organisation involved in mitosis" EXACT [GOC:TermGenie]
synonym: "microtubule cytoskeleton organization and biogenesis involved in mitosis" RELATED [GOC:TermGenie]
synonym: "microtubule dynamics involved in mitosis" EXACT [GOC:TermGenie]
is_a: GO:0000226 ! microtubule cytoskeleton organization
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0000226 ! microtubule cytoskeleton organization
intersection_of: part_of GO:0007067 ! mitotic nuclear division
relationship: part_of GO:0007067 ! mitotic nuclear division
created_by: vw
creation_date: 2014-04-02T14:19:38Z

[Term]
id: GO:1902852
name: regulation of nuclear migration during mitotic telophase
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nuclear migration during mitotic telophase." [GO_REF:0000058, GOC:TermGenie, PMID:23087209]
is_a: GO:1902838 ! regulation of nuclear migration along microtubule
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0090561 ! nuclear migration during mitotic telophase
relationship: regulates GO:0090561 ! nuclear migration during mitotic telophase
created_by: vw
creation_date: 2014-04-02T15:35:34Z

[Term]
id: GO:1902853
name: negative regulation of nuclear migration during mitotic telophase
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of nuclear migration during mitotic telophase." [GO_REF:0000058, GOC:TermGenie, PMID:23087209]
synonym: "down regulation of nuclear migration during mitotic telophase" EXACT [GOC:TermGenie]
synonym: "down-regulation of nuclear migration during mitotic telophase" EXACT [GOC:TermGenie]
synonym: "downregulation of nuclear migration during mitotic telophase" EXACT [GOC:TermGenie]
synonym: "inhibition of nuclear migration during mitotic telophase" NARROW [GOC:TermGenie]
is_a: GO:1902839 ! negative regulation of nuclear migration along microtubule
is_a: GO:1902852 ! regulation of nuclear migration during mitotic telophase
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0090561 ! nuclear migration during mitotic telophase
relationship: negatively_regulates GO:0090561 ! nuclear migration during mitotic telophase
created_by: vw
creation_date: 2014-04-02T15:35:56Z

[Term]
id: GO:1902854
name: positive regulation of nuclear migration during mitotic telophase
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of nuclear migration during mitotic telophase." [GO_REF:0000058, GOC:TermGenie, PMID:23087209]
synonym: "activation of nuclear migration during mitotic telophase" NARROW [GOC:TermGenie]
synonym: "up regulation of nuclear migration during mitotic telophase" EXACT [GOC:TermGenie]
synonym: "up-regulation of nuclear migration during mitotic telophase" EXACT [GOC:TermGenie]
synonym: "upregulation of nuclear migration during mitotic telophase" EXACT [GOC:TermGenie]
is_a: GO:1902840 ! positive regulation of nuclear migration along microtubule
is_a: GO:1902852 ! regulation of nuclear migration during mitotic telophase
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0090561 ! nuclear migration during mitotic telophase
relationship: positively_regulates GO:0090561 ! nuclear migration during mitotic telophase
created_by: vw
creation_date: 2014-04-02T15:36:06Z

[Term]
id: GO:1902855
name: regulation of nonmotile primary cilium assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nonmotile primary cilium assembly." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:23807208]
synonym: "regulation of immotile primary cilium assembly" EXACT [GOC:TermGenie]
synonym: "regulation of nonmotile primary cilia assembly" RELATED [GOC:TermGenie]
synonym: "regulation of sensory cilium assembly" EXACT [GOC:TermGenie]
synonym: "regulation of sensory cilium biogenesis" RELATED [GOC:TermGenie]
is_a: GO:1902017 ! regulation of cilium assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035058 ! nonmotile primary cilium assembly
relationship: regulates GO:0035058 ! nonmotile primary cilium assembly
created_by: kmv
creation_date: 2014-04-02T15:41:57Z

[Term]
id: GO:1902856
name: negative regulation of nonmotile primary cilium assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of nonmotile primary cilium assembly." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:23807208]
synonym: "down regulation of immotile primary cilium assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of nonmotile primary cilia assembly" RELATED [GOC:TermGenie]
synonym: "down regulation of nonmotile primary cilium assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of sensory cilium assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of sensory cilium biogenesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of immotile primary cilium assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of nonmotile primary cilia assembly" RELATED [GOC:TermGenie]
synonym: "down-regulation of nonmotile primary cilium assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of sensory cilium assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of sensory cilium biogenesis" RELATED [GOC:TermGenie]
synonym: "downregulation of immotile primary cilium assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of nonmotile primary cilia assembly" RELATED [GOC:TermGenie]
synonym: "downregulation of nonmotile primary cilium assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of sensory cilium assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of sensory cilium biogenesis" RELATED [GOC:TermGenie]
synonym: "inhibition of immotile primary cilium assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of nonmotile primary cilia assembly" RELATED [GOC:TermGenie]
synonym: "inhibition of nonmotile primary cilium assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of sensory cilium assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of sensory cilium biogenesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of immotile primary cilium assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of nonmotile primary cilia assembly" RELATED [GOC:TermGenie]
synonym: "negative regulation of sensory cilium assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of sensory cilium biogenesis" RELATED [GOC:TermGenie]
is_a: GO:1902018 ! negative regulation of cilium assembly
is_a: GO:1902855 ! regulation of nonmotile primary cilium assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035058 ! nonmotile primary cilium assembly
relationship: negatively_regulates GO:0035058 ! nonmotile primary cilium assembly
created_by: kmv
creation_date: 2014-04-02T15:42:17Z

[Term]
id: GO:1902857
name: positive regulation of nonmotile primary cilium assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of nonmotile primary cilium assembly." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:23807208]
synonym: "activation of immotile primary cilium assembly" NARROW [GOC:TermGenie]
synonym: "activation of nonmotile primary cilia assembly" RELATED [GOC:TermGenie]
synonym: "activation of nonmotile primary cilium assembly" NARROW [GOC:TermGenie]
synonym: "activation of sensory cilium assembly" NARROW [GOC:TermGenie]
synonym: "activation of sensory cilium biogenesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of immotile primary cilium assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of nonmotile primary cilia assembly" RELATED [GOC:TermGenie]
synonym: "positive regulation of sensory cilium assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of sensory cilium biogenesis" RELATED [GOC:TermGenie]
synonym: "up regulation of immotile primary cilium assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of nonmotile primary cilia assembly" RELATED [GOC:TermGenie]
synonym: "up regulation of nonmotile primary cilium assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of sensory cilium assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of sensory cilium biogenesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of immotile primary cilium assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of nonmotile primary cilia assembly" RELATED [GOC:TermGenie]
synonym: "up-regulation of nonmotile primary cilium assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of sensory cilium assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of sensory cilium biogenesis" RELATED [GOC:TermGenie]
synonym: "upregulation of immotile primary cilium assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of nonmotile primary cilia assembly" RELATED [GOC:TermGenie]
synonym: "upregulation of nonmotile primary cilium assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of sensory cilium assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of sensory cilium biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0045724 ! positive regulation of cilium assembly
is_a: GO:1902855 ! regulation of nonmotile primary cilium assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035058 ! nonmotile primary cilium assembly
relationship: positively_regulates GO:0035058 ! nonmotile primary cilium assembly
created_by: kmv
creation_date: 2014-04-02T15:42:31Z

[Term]
id: GO:1902858
name: propionyl-CoA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving propionyl-CoA." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:15514053]
synonym: "propionyl-CoA metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006637 ! acyl-CoA metabolic process
created_by: tt
creation_date: 2014-04-03T03:10:17Z

[Term]
id: GO:1902859
name: propionyl-CoA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of propionyl-CoA." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:15514053]
synonym: "propionyl-CoA breakdown" EXACT [GOC:TermGenie]
synonym: "propionyl-CoA catabolism" EXACT [GOC:TermGenie]
synonym: "propionyl-CoA degradation" EXACT [GOC:TermGenie]
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:1901575 ! organic substance catabolic process
is_a: GO:1902858 ! propionyl-CoA metabolic process
created_by: tt
creation_date: 2014-04-03T03:10:23Z

[Term]
id: GO:1902860
name: propionyl-CoA biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of propionyl-CoA." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:15514053]
synonym: "propionyl-CoA anabolism" EXACT [GOC:TermGenie]
synonym: "propionyl-CoA biosynthesis" EXACT [GOC:TermGenie]
synonym: "propionyl-CoA formation" EXACT [GOC:TermGenie]
synonym: "propionyl-CoA synthesis" EXACT [GOC:TermGenie]
is_a: GO:0071616 ! acyl-CoA biosynthetic process
is_a: GO:1902858 ! propionyl-CoA metabolic process
created_by: tt
creation_date: 2014-04-03T03:10:29Z

[Term]
id: GO:1902861
name: copper ion import into cell
namespace: biological_process
def: "The directed movement of copper ions from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [GO_REF:0000075, GOC:TermGenie, PMID:12244050]
synonym: "copper cation import into cell" EXACT [CHEBI:23378]
synonym: "copper import into cell" BROAD [GOC:mah]
is_a: GO:0015677 ! copper ion import
is_a: GO:0098659 ! inorganic cation import into cell
created_by: mah
creation_date: 2014-04-03T13:26:04Z

[Term]
id: GO:1902862
name: obsolete glycerol catabolic process to glycerone phosphate
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of glycerol to glycerone phosphate." [GO_REF:0000093, GOC:dph, GOC:TermGenie, ISBN:0201090910]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "glycerol breakdown to glycerone phosphate" EXACT [GOC:TermGenie]
synonym: "glycerol catabolic process to glycerone phosphate" EXACT []
synonym: "glycerol catabolism to glycerone phosphate" EXACT [GOC:TermGenie]
synonym: "glycerol degradation to glycerone phosphate" EXACT [GOC:TermGenie]
is_obsolete: true
created_by: dph
creation_date: 2014-04-03T14:42:01Z

[Term]
id: GO:1902863
name: regulation of embryonic camera-type eye development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of embryonic camera-type eye development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]
synonym: "regulation of embryonic eye development" EXACT [GOC:TermGenie]
is_a: GO:0045995 ! regulation of embryonic development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031076 ! embryonic camera-type eye development
relationship: regulates GO:0031076 ! embryonic camera-type eye development
created_by: mr
creation_date: 2014-04-03T15:24:00Z

[Term]
id: GO:1902864
name: negative regulation of embryonic camera-type eye development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of embryonic camera-type eye development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]
synonym: "down regulation of embryonic camera-type eye development" EXACT [GOC:TermGenie]
synonym: "down regulation of embryonic eye development" EXACT [GOC:TermGenie]
synonym: "down-regulation of embryonic camera-type eye development" EXACT [GOC:TermGenie]
synonym: "down-regulation of embryonic eye development" EXACT [GOC:TermGenie]
synonym: "downregulation of embryonic camera-type eye development" EXACT [GOC:TermGenie]
synonym: "downregulation of embryonic eye development" EXACT [GOC:TermGenie]
synonym: "inhibition of embryonic camera-type eye development" NARROW [GOC:TermGenie]
synonym: "inhibition of embryonic eye development" NARROW [GOC:TermGenie]
synonym: "negative regulation of embryonic eye development" EXACT [GOC:TermGenie]
is_a: GO:0045992 ! negative regulation of embryonic development
is_a: GO:1902863 ! regulation of embryonic camera-type eye development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0031076 ! embryonic camera-type eye development
relationship: negatively_regulates GO:0031076 ! embryonic camera-type eye development
created_by: mr
creation_date: 2014-04-03T15:24:06Z

[Term]
id: GO:1902865
name: positive regulation of embryonic camera-type eye development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of embryonic camera-type eye development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]
synonym: "activation of embryonic camera-type eye development" NARROW [GOC:TermGenie]
synonym: "activation of embryonic eye development" NARROW [GOC:TermGenie]
synonym: "positive regulation of embryonic eye development" EXACT [GOC:TermGenie]
synonym: "up regulation of embryonic camera-type eye development" EXACT [GOC:TermGenie]
synonym: "up regulation of embryonic eye development" EXACT [GOC:TermGenie]
synonym: "up-regulation of embryonic camera-type eye development" EXACT [GOC:TermGenie]
synonym: "up-regulation of embryonic eye development" EXACT [GOC:TermGenie]
synonym: "upregulation of embryonic camera-type eye development" EXACT [GOC:TermGenie]
synonym: "upregulation of embryonic eye development" EXACT [GOC:TermGenie]
is_a: GO:0040019 ! positive regulation of embryonic development
is_a: GO:1902863 ! regulation of embryonic camera-type eye development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0031076 ! embryonic camera-type eye development
relationship: positively_regulates GO:0031076 ! embryonic camera-type eye development
created_by: mr
creation_date: 2014-04-03T15:24:12Z

[Term]
id: GO:1902866
name: regulation of retina development in camera-type eye
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of retina development in camera-type eye." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]
synonym: "regulation of retina development in camera-style eye" EXACT [GOC:TermGenie]
synonym: "regulation of retinal development" RELATED [GOC:TermGenie]
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060041 ! retina development in camera-type eye
relationship: regulates GO:0060041 ! retina development in camera-type eye
created_by: mr
creation_date: 2014-04-03T15:24:17Z

[Term]
id: GO:1902867
name: negative regulation of retina development in camera-type eye
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of retina development in camera-type eye." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]
synonym: "down regulation of retina development in camera-style eye" EXACT [GOC:TermGenie]
synonym: "down regulation of retina development in camera-type eye" EXACT [GOC:TermGenie]
synonym: "down regulation of retinal development" RELATED [GOC:TermGenie]
synonym: "down-regulation of retina development in camera-style eye" EXACT [GOC:TermGenie]
synonym: "down-regulation of retina development in camera-type eye" EXACT [GOC:TermGenie]
synonym: "down-regulation of retinal development" RELATED [GOC:TermGenie]
synonym: "downregulation of retina development in camera-style eye" EXACT [GOC:TermGenie]
synonym: "downregulation of retina development in camera-type eye" EXACT [GOC:TermGenie]
synonym: "downregulation of retinal development" RELATED [GOC:TermGenie]
synonym: "inhibition of retina development in camera-style eye" NARROW [GOC:TermGenie]
synonym: "inhibition of retina development in camera-type eye" NARROW [GOC:TermGenie]
synonym: "inhibition of retinal development" RELATED [GOC:TermGenie]
synonym: "negative regulation of retina development in camera-style eye" EXACT [GOC:TermGenie]
synonym: "negative regulation of retinal development" RELATED [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1902866 ! regulation of retina development in camera-type eye
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060041 ! retina development in camera-type eye
relationship: negatively_regulates GO:0060041 ! retina development in camera-type eye
created_by: mr
creation_date: 2014-04-03T15:24:23Z

[Term]
id: GO:1902868
name: positive regulation of retina development in camera-type eye
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of retina development in camera-type eye." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]
synonym: "activation of retina development in camera-style eye" NARROW [GOC:TermGenie]
synonym: "activation of retina development in camera-type eye" NARROW [GOC:TermGenie]
synonym: "activation of retinal development" RELATED [GOC:TermGenie]
synonym: "positive regulation of retina development in camera-style eye" EXACT [GOC:TermGenie]
synonym: "positive regulation of retinal development" RELATED [GOC:TermGenie]
synonym: "up regulation of retina development in camera-style eye" EXACT [GOC:TermGenie]
synonym: "up regulation of retina development in camera-type eye" EXACT [GOC:TermGenie]
synonym: "up regulation of retinal development" RELATED [GOC:TermGenie]
synonym: "up-regulation of retina development in camera-style eye" EXACT [GOC:TermGenie]
synonym: "up-regulation of retina development in camera-type eye" EXACT [GOC:TermGenie]
synonym: "up-regulation of retinal development" RELATED [GOC:TermGenie]
synonym: "upregulation of retina development in camera-style eye" EXACT [GOC:TermGenie]
synonym: "upregulation of retina development in camera-type eye" EXACT [GOC:TermGenie]
synonym: "upregulation of retinal development" RELATED [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1902866 ! regulation of retina development in camera-type eye
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060041 ! retina development in camera-type eye
relationship: positively_regulates GO:0060041 ! retina development in camera-type eye
created_by: mr
creation_date: 2014-04-03T15:24:29Z

[Term]
id: GO:1902869
name: regulation of amacrine cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of amacrine cell differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]
synonym: "regulation of amacrine neuron differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045664 ! regulation of neuron differentiation
is_a: GO:0061074 ! regulation of neural retina development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035881 ! amacrine cell differentiation
relationship: regulates GO:0035881 ! amacrine cell differentiation
created_by: mr
creation_date: 2014-04-03T15:24:35Z

[Term]
id: GO:1902870
name: negative regulation of amacrine cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of amacrine cell differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]
synonym: "down regulation of amacrine cell differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of amacrine neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of amacrine cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of amacrine neuron differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of amacrine cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of amacrine neuron differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of amacrine cell differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of amacrine neuron differentiation" NARROW [GOC:TermGenie]
synonym: "negative regulation of amacrine neuron differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045665 ! negative regulation of neuron differentiation
is_a: GO:0061076 ! negative regulation of neural retina development
is_a: GO:1902869 ! regulation of amacrine cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035881 ! amacrine cell differentiation
relationship: negatively_regulates GO:0035881 ! amacrine cell differentiation
created_by: mr
creation_date: 2014-04-03T15:24:40Z

[Term]
id: GO:1902871
name: positive regulation of amacrine cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of amacrine cell differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]
synonym: "activation of amacrine cell differentiation" NARROW [GOC:TermGenie]
synonym: "activation of amacrine neuron differentiation" NARROW [GOC:TermGenie]
synonym: "positive regulation of amacrine neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of amacrine cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of amacrine neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of amacrine cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of amacrine neuron differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of amacrine cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of amacrine neuron differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045666 ! positive regulation of neuron differentiation
is_a: GO:0061075 ! positive regulation of neural retina development
is_a: GO:1902869 ! regulation of amacrine cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035881 ! amacrine cell differentiation
relationship: positively_regulates GO:0035881 ! amacrine cell differentiation
created_by: mr
creation_date: 2014-04-03T15:24:46Z

[Term]
id: GO:1902872
name: regulation of horizontal cell localization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of horizontal cell localization." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]
synonym: "regulation of horizontal cell localisation" EXACT [GOC:TermGenie]
synonym: "regulation of horizontal cell positioning" EXACT [GOC:TermGenie]
synonym: "regulation of laminar positioning of retinal horizontal cell" EXACT [GOC:TermGenie]
synonym: "regulation of retinal horizontal cell positioning" EXACT [GOC:TermGenie]
is_a: GO:0032879 ! regulation of localization
is_a: GO:0061074 ! regulation of neural retina development
is_a: GO:2000027 ! regulation of organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035852 ! horizontal cell localization
relationship: regulates GO:0035852 ! horizontal cell localization
created_by: mr
creation_date: 2014-04-03T15:24:58Z

[Term]
id: GO:1902873
name: negative regulation of horizontal cell localization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of horizontal cell localization." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]
synonym: "down regulation of horizontal cell localisation" EXACT [GOC:TermGenie]
synonym: "down regulation of horizontal cell localization" EXACT [GOC:TermGenie]
synonym: "down regulation of horizontal cell positioning" EXACT [GOC:TermGenie]
synonym: "down regulation of laminar positioning of retinal horizontal cell" EXACT [GOC:TermGenie]
synonym: "down regulation of retinal horizontal cell positioning" EXACT [GOC:TermGenie]
synonym: "down-regulation of horizontal cell localisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of horizontal cell localization" EXACT [GOC:TermGenie]
synonym: "down-regulation of horizontal cell positioning" EXACT [GOC:TermGenie]
synonym: "down-regulation of laminar positioning of retinal horizontal cell" EXACT [GOC:TermGenie]
synonym: "down-regulation of retinal horizontal cell positioning" EXACT [GOC:TermGenie]
synonym: "downregulation of horizontal cell localisation" EXACT [GOC:TermGenie]
synonym: "downregulation of horizontal cell localization" EXACT [GOC:TermGenie]
synonym: "downregulation of horizontal cell positioning" EXACT [GOC:TermGenie]
synonym: "downregulation of laminar positioning of retinal horizontal cell" EXACT [GOC:TermGenie]
synonym: "downregulation of retinal horizontal cell positioning" EXACT [GOC:TermGenie]
synonym: "inhibition of horizontal cell localisation" NARROW [GOC:TermGenie]
synonym: "inhibition of horizontal cell localization" NARROW [GOC:TermGenie]
synonym: "inhibition of horizontal cell positioning" NARROW [GOC:TermGenie]
synonym: "inhibition of laminar positioning of retinal horizontal cell" NARROW [GOC:TermGenie]
synonym: "inhibition of retinal horizontal cell positioning" NARROW [GOC:TermGenie]
synonym: "negative regulation of horizontal cell localisation" EXACT [GOC:TermGenie]
synonym: "negative regulation of horizontal cell positioning" EXACT [GOC:TermGenie]
synonym: "negative regulation of laminar positioning of retinal horizontal cell" EXACT [GOC:TermGenie]
synonym: "negative regulation of retinal horizontal cell positioning" EXACT [GOC:TermGenie]
is_a: GO:0061076 ! negative regulation of neural retina development
is_a: GO:1902872 ! regulation of horizontal cell localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035852 ! horizontal cell localization
relationship: negatively_regulates GO:0035852 ! horizontal cell localization
created_by: mr
creation_date: 2014-04-03T15:25:03Z

[Term]
id: GO:1902874
name: positive regulation of horizontal cell localization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of horizontal cell localization." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]
synonym: "activation of horizontal cell localisation" NARROW [GOC:TermGenie]
synonym: "activation of horizontal cell localization" NARROW [GOC:TermGenie]
synonym: "activation of horizontal cell positioning" NARROW [GOC:TermGenie]
synonym: "activation of laminar positioning of retinal horizontal cell" NARROW [GOC:TermGenie]
synonym: "activation of retinal horizontal cell positioning" NARROW [GOC:TermGenie]
synonym: "positive regulation of horizontal cell localisation" EXACT [GOC:TermGenie]
synonym: "positive regulation of horizontal cell positioning" EXACT [GOC:TermGenie]
synonym: "positive regulation of laminar positioning of retinal horizontal cell" EXACT [GOC:TermGenie]
synonym: "positive regulation of retinal horizontal cell positioning" EXACT [GOC:TermGenie]
synonym: "up regulation of horizontal cell localisation" EXACT [GOC:TermGenie]
synonym: "up regulation of horizontal cell localization" EXACT [GOC:TermGenie]
synonym: "up regulation of horizontal cell positioning" EXACT [GOC:TermGenie]
synonym: "up regulation of laminar positioning of retinal horizontal cell" EXACT [GOC:TermGenie]
synonym: "up regulation of retinal horizontal cell positioning" EXACT [GOC:TermGenie]
synonym: "up-regulation of horizontal cell localisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of horizontal cell localization" EXACT [GOC:TermGenie]
synonym: "up-regulation of horizontal cell positioning" EXACT [GOC:TermGenie]
synonym: "up-regulation of laminar positioning of retinal horizontal cell" EXACT [GOC:TermGenie]
synonym: "up-regulation of retinal horizontal cell positioning" EXACT [GOC:TermGenie]
synonym: "upregulation of horizontal cell localisation" EXACT [GOC:TermGenie]
synonym: "upregulation of horizontal cell localization" EXACT [GOC:TermGenie]
synonym: "upregulation of horizontal cell positioning" EXACT [GOC:TermGenie]
synonym: "upregulation of laminar positioning of retinal horizontal cell" EXACT [GOC:TermGenie]
synonym: "upregulation of retinal horizontal cell positioning" EXACT [GOC:TermGenie]
is_a: GO:0061075 ! positive regulation of neural retina development
is_a: GO:1902872 ! regulation of horizontal cell localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035852 ! horizontal cell localization
relationship: positively_regulates GO:0035852 ! horizontal cell localization
created_by: mr
creation_date: 2014-04-03T15:25:09Z

[Term]
id: GO:1902875
name: regulation of embryonic pattern specification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of embryonic pattern specification." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]
synonym: "regulation of embryonic pattern biosynthesis" BROAD [GOC:TermGenie]
synonym: "regulation of embryonic pattern formation" BROAD [GOC:TermGenie]
synonym: "regulation of ventral/lateral system" RELATED [GOC:TermGenie]
is_a: GO:0045995 ! regulation of embryonic development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009880 ! embryonic pattern specification
relationship: regulates GO:0009880 ! embryonic pattern specification
created_by: mr
creation_date: 2014-04-03T15:25:15Z

[Term]
id: GO:1902876
name: negative regulation of embryonic pattern specification
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of embryonic pattern specification." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]
synonym: "down regulation of embryonic pattern specification" EXACT [GOC:TermGenie]
synonym: "down regulation of ventral/lateral system" RELATED [GOC:TermGenie]
synonym: "down-regulation of embryonic pattern specification" EXACT [GOC:TermGenie]
synonym: "down-regulation of ventral/lateral system" RELATED [GOC:TermGenie]
synonym: "downregulation of embryonic pattern specification" EXACT [GOC:TermGenie]
synonym: "downregulation of ventral/lateral system" RELATED [GOC:TermGenie]
synonym: "inhibition of embryonic pattern specification" NARROW [GOC:TermGenie]
synonym: "inhibition of ventral/lateral system" RELATED [GOC:TermGenie]
synonym: "negative regulation of ventral/lateral system" RELATED [GOC:TermGenie]
is_a: GO:0045992 ! negative regulation of embryonic development
is_a: GO:1902875 ! regulation of embryonic pattern specification
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009880 ! embryonic pattern specification
relationship: negatively_regulates GO:0009880 ! embryonic pattern specification
created_by: mr
creation_date: 2014-04-03T15:25:20Z

[Term]
id: GO:1902877
name: positive regulation of embryonic pattern specification
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of embryonic pattern specification." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]
synonym: "activation of embryonic pattern specification" NARROW [GOC:TermGenie]
synonym: "activation of ventral/lateral system" RELATED [GOC:TermGenie]
synonym: "positive regulation of ventral/lateral system" RELATED [GOC:TermGenie]
synonym: "up regulation of embryonic pattern specification" EXACT [GOC:TermGenie]
synonym: "up regulation of ventral/lateral system" RELATED [GOC:TermGenie]
synonym: "up-regulation of embryonic pattern specification" EXACT [GOC:TermGenie]
synonym: "up-regulation of ventral/lateral system" RELATED [GOC:TermGenie]
synonym: "upregulation of embryonic pattern specification" EXACT [GOC:TermGenie]
synonym: "upregulation of ventral/lateral system" RELATED [GOC:TermGenie]
is_a: GO:0040019 ! positive regulation of embryonic development
is_a: GO:1902875 ! regulation of embryonic pattern specification
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009880 ! embryonic pattern specification
relationship: positively_regulates GO:0009880 ! embryonic pattern specification
created_by: mr
creation_date: 2014-04-03T15:25:26Z

[Term]
id: GO:1902878
name: regulation of BMP signaling pathway involved in spinal cord association neuron specification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of BMP signaling pathway involved in spinal cord association neuron specification." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:21730158]
synonym: "regulation of BMP signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "regulation of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "regulation of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
is_a: GO:0008589 ! regulation of smoothened signaling pathway
is_a: GO:0030510 ! regulation of BMP signaling pathway
is_a: GO:0042659 ! regulation of cell fate specification
is_a: GO:1902829 ! regulation of spinal cord association neuron differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0021777 ! BMP signaling pathway involved in spinal cord association neuron specification
relationship: regulates GO:0021777 ! BMP signaling pathway involved in spinal cord association neuron specification
created_by: mr
creation_date: 2014-04-03T15:25:32Z

[Term]
id: GO:1902879
name: negative regulation of BMP signaling pathway involved in spinal cord association neuron specification
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of BMP signaling pathway involved in spinal cord association neuron specification." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:21730158]
synonym: "down regulation of BMP signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "down regulation of BMP signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "down regulation of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "down regulation of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "down-regulation of BMP signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "down-regulation of BMP signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "down-regulation of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "down-regulation of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "downregulation of BMP signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "downregulation of BMP signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "downregulation of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "downregulation of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "inhibition of BMP signaling pathway involved in spinal cord association neuron specification" NARROW [GOC:TermGenie]
synonym: "inhibition of BMP signalling pathway involved in spinal cord association neuron specification" NARROW [GOC:TermGenie]
synonym: "inhibition of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification" NARROW [GOC:TermGenie]
synonym: "inhibition of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification" NARROW [GOC:TermGenie]
synonym: "negative regulation of BMP signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "negative regulation of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "negative regulation of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
is_a: GO:0009996 ! negative regulation of cell fate specification
is_a: GO:0030514 ! negative regulation of BMP signaling pathway
is_a: GO:0045880 ! positive regulation of smoothened signaling pathway
is_a: GO:0051962 ! positive regulation of nervous system development
is_a: GO:1902830 ! negative regulation of spinal cord association neuron differentiation
is_a: GO:1902878 ! regulation of BMP signaling pathway involved in spinal cord association neuron specification
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0021777 ! BMP signaling pathway involved in spinal cord association neuron specification
relationship: negatively_regulates GO:0021777 ! BMP signaling pathway involved in spinal cord association neuron specification
created_by: mr
creation_date: 2014-04-03T15:25:38Z

[Term]
id: GO:1902880
name: positive regulation of BMP signaling pathway involved in spinal cord association neuron specification
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of BMP signaling pathway involved in spinal cord association neuron specification." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:21730158]
synonym: "activation of BMP signaling pathway involved in spinal cord association neuron specification" NARROW [GOC:TermGenie]
synonym: "activation of BMP signalling pathway involved in spinal cord association neuron specification" NARROW [GOC:TermGenie]
synonym: "activation of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification" NARROW [GOC:TermGenie]
synonym: "activation of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification" NARROW [GOC:TermGenie]
synonym: "positive regulation of BMP signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "positive regulation of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "positive regulation of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "up regulation of BMP signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "up regulation of BMP signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "up regulation of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "up regulation of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "up-regulation of BMP signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "up-regulation of BMP signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "up-regulation of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "up-regulation of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "upregulation of BMP signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "upregulation of BMP signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "upregulation of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
synonym: "upregulation of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie]
is_a: GO:0030513 ! positive regulation of BMP signaling pathway
is_a: GO:0042660 ! positive regulation of cell fate specification
is_a: GO:1902831 ! positive regulation of spinal cord association neuron differentiation
is_a: GO:1902878 ! regulation of BMP signaling pathway involved in spinal cord association neuron specification
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0021777 ! BMP signaling pathway involved in spinal cord association neuron specification
relationship: positively_regulates GO:0021777 ! BMP signaling pathway involved in spinal cord association neuron specification
created_by: mr
creation_date: 2014-04-03T15:25:43Z

[Term]
id: GO:1902882
name: regulation of response to oxidative stress
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to oxidative stress." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:16899554]
is_a: GO:0080134 ! regulation of response to stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006979 ! response to oxidative stress
relationship: regulates GO:0006979 ! response to oxidative stress
created_by: kmv
creation_date: 2014-04-03T20:29:52Z

[Term]
id: GO:1902883
name: negative regulation of response to oxidative stress
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to oxidative stress." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:16899554]
synonym: "down regulation of response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "downregulation of response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "inhibition of response to oxidative stress" NARROW [GOC:TermGenie]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1902882 ! regulation of response to oxidative stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006979 ! response to oxidative stress
relationship: negatively_regulates GO:0006979 ! response to oxidative stress
created_by: kmv
creation_date: 2014-04-03T20:30:20Z

[Term]
id: GO:1902884
name: positive regulation of response to oxidative stress
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to oxidative stress." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:16899554]
synonym: "activation of response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "up regulation of response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "upregulation of response to oxidative stress" EXACT [GOC:TermGenie]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1902882 ! regulation of response to oxidative stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006979 ! response to oxidative stress
relationship: positively_regulates GO:0006979 ! response to oxidative stress
created_by: kmv
creation_date: 2014-04-03T20:30:47Z

[Term]
id: GO:1902885
name: regulation of proteasome-activating ATPase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of proteasome-activating ATPase activity." [GO_REF:0000059, GOC:di, GOC:TermGenie, PMID:23995839]
synonym: "regulation of ATPase involved in positive regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of proteasomal ATPase activity" EXACT [GOC:TermGenie]
synonym: "regulation of proteasome channel gating activity" NARROW [GOC:TermGenie]
synonym: "regulation of proteasome channel opening activity" NARROW [GOC:TermGenie]
is_a: GO:0043462 ! regulation of ATPase activity
is_a: GO:0061136 ! regulation of proteasomal protein catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0036402 ! proteasome-activating ATPase activity
relationship: regulates GO:0036402 ! proteasome-activating ATPase activity
created_by: di
creation_date: 2014-04-04T17:35:23Z

[Term]
id: GO:1902886
name: negative regulation of proteasome-activating ATPase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of proteasome-activating ATPase activity." [GO_REF:0000059, GOC:di, GOC:TermGenie, PMID:23995839]
synonym: "down regulation of ATPase involved in positive regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of proteasomal ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of proteasome channel gating activity" NARROW [GOC:TermGenie]
synonym: "down regulation of proteasome channel opening activity" NARROW [GOC:TermGenie]
synonym: "down regulation of proteasome-activating ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of ATPase involved in positive regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of proteasomal ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of proteasome channel gating activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of proteasome channel opening activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of proteasome-activating ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of ATPase involved in positive regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of proteasomal ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of proteasome channel gating activity" NARROW [GOC:TermGenie]
synonym: "downregulation of proteasome channel opening activity" NARROW [GOC:TermGenie]
synonym: "downregulation of proteasome-activating ATPase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of ATPase involved in positive regulation of proteasomal protein catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of proteasomal ATPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of proteasome channel gating activity" NARROW [GOC:TermGenie]
synonym: "inhibition of proteasome channel opening activity" NARROW [GOC:TermGenie]
synonym: "inhibition of proteasome-activating ATPase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of ATPase involved in positive regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of proteasomal ATPase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of proteasome channel gating activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of proteasome channel opening activity" NARROW [GOC:TermGenie]
is_a: GO:0032780 ! negative regulation of ATPase activity
is_a: GO:1902885 ! regulation of proteasome-activating ATPase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0036402 ! proteasome-activating ATPase activity
relationship: negatively_regulates GO:0036402 ! proteasome-activating ATPase activity
created_by: di
creation_date: 2014-04-04T17:35:30Z

[Term]
id: GO:1902887
name: positive regulation of proteasome-activating ATPase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of proteasome-activating ATPase activity." [GO_REF:0000059, GOC:di, GOC:TermGenie, PMID:23995839]
synonym: "activation of ATPase involved in positive regulation of proteasomal protein catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of proteasomal ATPase activity" NARROW [GOC:TermGenie]
synonym: "activation of proteasome channel gating activity" NARROW [GOC:TermGenie]
synonym: "activation of proteasome channel opening activity" NARROW [GOC:TermGenie]
synonym: "activation of proteasome-activating ATPase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of ATPase involved in positive regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of proteasomal ATPase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of proteasome channel gating activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of proteasome channel opening activity" NARROW [GOC:TermGenie]
synonym: "up regulation of ATPase involved in positive regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of proteasomal ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of proteasome channel gating activity" NARROW [GOC:TermGenie]
synonym: "up regulation of proteasome channel opening activity" NARROW [GOC:TermGenie]
synonym: "up regulation of proteasome-activating ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of ATPase involved in positive regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of proteasomal ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of proteasome channel gating activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of proteasome channel opening activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of proteasome-activating ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of ATPase involved in positive regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of proteasomal ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of proteasome channel gating activity" NARROW [GOC:TermGenie]
synonym: "upregulation of proteasome channel opening activity" NARROW [GOC:TermGenie]
synonym: "upregulation of proteasome-activating ATPase activity" EXACT [GOC:TermGenie]
is_a: GO:0032781 ! positive regulation of ATPase activity
is_a: GO:1902885 ! regulation of proteasome-activating ATPase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0036402 ! proteasome-activating ATPase activity
relationship: positively_regulates GO:0036402 ! proteasome-activating ATPase activity
created_by: di
creation_date: 2014-04-04T17:35:36Z

[Term]
id: GO:1902888
name: protein localization to astral microtubule
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within an astral microtubule." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:16054030]
synonym: "protein localisation in astral microtubule" EXACT [GOC:TermGenie]
synonym: "protein localisation to astral microtubule" EXACT [GOC:TermGenie]
synonym: "protein localization in astral microtubule" EXACT [GOC:TermGenie]
is_a: GO:1902889 ! protein localization to spindle microtubule
created_by: kmv
creation_date: 2014-04-05T21:26:34Z

[Term]
id: GO:1902889
name: protein localization to spindle microtubule
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a spindle microtubule." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:16054030]
synonym: "protein localisation in spindle microtubule" EXACT [GOC:TermGenie]
synonym: "protein localisation to spindle microtubule" EXACT [GOC:TermGenie]
synonym: "protein localization in spindle microtubule" EXACT [GOC:TermGenie]
is_a: GO:0035372 ! protein localization to microtubule
created_by: kmv
creation_date: 2014-04-05T21:31:39Z

[Term]
id: GO:1902890
name: regulation of root hair elongation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of root hair elongation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22329353]
is_a: GO:0001558 ! regulation of cell growth
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:1903429 ! regulation of cell maturation
is_a: GO:1903888 ! regulation of plant epidermal cell differentiation
is_a: GO:2000067 ! regulation of root morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048767 ! root hair elongation
relationship: regulates GO:0048767 ! root hair elongation
created_by: als
creation_date: 2014-04-07T13:46:40Z

[Term]
id: GO:1902891
name: negative regulation of root hair elongation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of root hair elongation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22329353]
synonym: "down regulation of root hair elongation" EXACT [GOC:TermGenie]
synonym: "down-regulation of root hair elongation" EXACT [GOC:TermGenie]
synonym: "downregulation of root hair elongation" EXACT [GOC:TermGenie]
synonym: "inhibition of root hair elongation" NARROW [GOC:TermGenie]
is_a: GO:0030308 ! negative regulation of cell growth
is_a: GO:0048640 ! negative regulation of developmental growth
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1902890 ! regulation of root hair elongation
is_a: GO:1903430 ! negative regulation of cell maturation
is_a: GO:1903889 ! negative regulation of plant epidermal cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048767 ! root hair elongation
relationship: negatively_regulates GO:0048767 ! root hair elongation
created_by: als
creation_date: 2014-04-07T13:46:47Z

[Term]
id: GO:1902892
name: positive regulation of root hair elongation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of root hair elongation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22329353]
synonym: "activation of root hair elongation" NARROW [GOC:TermGenie]
synonym: "up regulation of root hair elongation" EXACT [GOC:TermGenie]
synonym: "up-regulation of root hair elongation" EXACT [GOC:TermGenie]
synonym: "upregulation of root hair elongation" EXACT [GOC:TermGenie]
is_a: GO:0030307 ! positive regulation of cell growth
is_a: GO:0048639 ! positive regulation of developmental growth
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1902890 ! regulation of root hair elongation
is_a: GO:1903431 ! positive regulation of cell maturation
is_a: GO:1903890 ! positive regulation of plant epidermal cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048767 ! root hair elongation
relationship: positively_regulates GO:0048767 ! root hair elongation
created_by: als
creation_date: 2014-04-07T13:46:53Z

[Term]
id: GO:1902893
name: regulation of pri-miRNA transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pri-miRNA transcription from RNA polymerase II promoter." [GO_REF:0000058, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24699545]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061614 ! pri-miRNA transcription from RNA polymerase II promoter
relationship: regulates GO:0061614 ! pri-miRNA transcription from RNA polymerase II promoter
created_by: dph
creation_date: 2014-04-08T13:22:08Z

[Term]
id: GO:1902894
name: negative regulation of pri-miRNA transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of pri-miRNA transcription from RNA polymerase II promoter." [GO_REF:0000058, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24699545]
synonym: "down regulation of pri-miRNA transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "down-regulation of pri-miRNA transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "downregulation of pri-miRNA transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "inhibition of pri-miRNA transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
is_a: GO:1902893 ! regulation of pri-miRNA transcription from RNA polymerase II promoter
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061614 ! pri-miRNA transcription from RNA polymerase II promoter
relationship: negatively_regulates GO:0061614 ! pri-miRNA transcription from RNA polymerase II promoter
created_by: dph
creation_date: 2014-04-08T13:22:14Z

[Term]
id: GO:1902895
name: positive regulation of pri-miRNA transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pri-miRNA transcription from RNA polymerase II promoter." [GO_REF:0000058, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24699545]
synonym: "activation of pri-miRNA transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "up regulation of pri-miRNA transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of pri-miRNA transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of pri-miRNA transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
is_a: GO:1902893 ! regulation of pri-miRNA transcription from RNA polymerase II promoter
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061614 ! pri-miRNA transcription from RNA polymerase II promoter
relationship: positively_regulates GO:0061614 ! pri-miRNA transcription from RNA polymerase II promoter
created_by: dph
creation_date: 2014-04-08T13:22:20Z

[Term]
id: GO:1902896
name: terminal web assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a terminal web." [GO_REF:0000079, GOC:kmv, GOC:TermGenie, pmid:21949650]
synonym: "terminal web formation" EXACT [GOC:TermGenie]
is_a: GO:0030866 ! cortical actin cytoskeleton organization
is_a: GO:0070925 ! organelle assembly
created_by: kmv
creation_date: 2014-04-08T15:15:25Z

[Term]
id: GO:1902897
name: regulation of postsynaptic density protein 95 clustering
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of postsynaptic density protein 95 clustering." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:10570482]
synonym: "regulation of Dlg4 clustering" EXACT [GOC:TermGenie]
synonym: "regulation of post-synaptic density protein 95 clustering" EXACT [GOC:TermGenie]
synonym: "regulation of PSD-95 clustering" EXACT [GOC:TermGenie]
is_a: GO:1901626 ! regulation of postsynaptic membrane organization
is_a: GO:1903827 ! regulation of cellular protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097119 ! postsynaptic density protein 95 clustering
relationship: regulates GO:0097119 ! postsynaptic density protein 95 clustering
created_by: als
creation_date: 2014-04-09T14:52:08Z

[Term]
id: GO:1902898
name: fatty acid methyl ester metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fatty acid methyl ester." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:16570218]
synonym: "FAME metabolic process" EXACT []
synonym: "fatty acid methyl ester metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006629 ! lipid metabolic process
created_by: tt
creation_date: 2014-04-11T03:08:34Z

[Term]
id: GO:1902899
name: fatty acid methyl ester biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of fatty acid methyl ester." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:16570218]
synonym: "FAME biosynthetic process" EXACT []
synonym: "fatty acid methyl ester anabolism" EXACT [GOC:TermGenie]
synonym: "fatty acid methyl ester biosynthesis" EXACT [GOC:TermGenie]
synonym: "fatty acid methyl ester formation" EXACT [GOC:TermGenie]
synonym: "fatty acid methyl ester synthesis" EXACT [GOC:TermGenie]
is_a: GO:0008610 ! lipid biosynthetic process
is_a: GO:1902898 ! fatty acid methyl ester metabolic process
created_by: tt
creation_date: 2014-04-11T03:08:40Z

[Term]
id: GO:1902900
name: gut granule assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a gut granule." [GO_REF:0000079, GOC:kmv, GOC:TermGenie, pmid:17202409]
synonym: "gut granule biogenesis" EXACT [pmid:17202409]
synonym: "gut granule formation" EXACT [GOC:TermGenie]
is_a: GO:0016050 ! vesicle organization
is_a: GO:0070925 ! organelle assembly
created_by: kmv
creation_date: 2014-04-14T14:28:17Z

[Term]
id: GO:1902901
name: positive regulation of transcription from RNA polymerase II promoter involved in stress response to cadmium ion
namespace: biological_process
def: "Any positive regulation of transcription from RNA polymerase II promoter that is involved in stress response to cadmium ion." [GO_REF:0000060, GOC:kmv, GOC:TermGenie, pmid:17888400]
synonym: "activation of global transcription from RNA polymerase II promoter involved in response to cadmium ion stress" RELATED [GOC:TermGenie]
synonym: "activation of global transcription from RNA polymerase II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie]
synonym: "activation of global transcription from RNA polymerase II promoter involved in stress response to cadmium ion" RELATED [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase II promoter involved in response to cadmium ion stress" EXACT [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase II promoter involved in stress response to cadmium ion" EXACT [GOC:TermGenie]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in response to cadmium ion stress" RELATED [GOC:TermGenie]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in stress response to cadmium ion" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription from Pol II promoter involved in response to cadmium ion stress" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription from Pol II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription from Pol II promoter involved in stress response to cadmium ion" RELATED [GOC:TermGenie]
synonym: "positive regulation of transcription from Pol II promoter involved in response to cadmium ion stress" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription from Pol II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie]
synonym: "positive regulation of transcription from Pol II promoter involved in stress response to cadmium ion" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription from RNA polymerase II promoter involved in response to cadmium ion stress" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription from RNA polymerase II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie]
synonym: "stimulation of global transcription from RNA polymerase II promoter involved in response to cadmium ion stress" NARROW [GOC:TermGenie]
synonym: "stimulation of global transcription from RNA polymerase II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie]
synonym: "stimulation of global transcription from RNA polymerase II promoter involved in stress response to cadmium ion" NARROW [GOC:TermGenie]
synonym: "stimulation of transcription from RNA polymerase II promoter involved in response to cadmium ion stress" EXACT [GOC:TermGenie]
synonym: "stimulation of transcription from RNA polymerase II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie]
synonym: "stimulation of transcription from RNA polymerase II promoter involved in stress response to cadmium ion" EXACT [GOC:TermGenie]
synonym: "up regulation of global transcription from RNA polymerase II promoter involved in response to cadmium ion stress" RELATED [GOC:TermGenie]
synonym: "up regulation of global transcription from RNA polymerase II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie]
synonym: "up regulation of global transcription from RNA polymerase II promoter involved in stress response to cadmium ion" RELATED [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase II promoter involved in response to cadmium ion stress" EXACT [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase II promoter involved in stress response to cadmium ion" EXACT [GOC:TermGenie]
synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in response to cadmium ion stress" RELATED [GOC:TermGenie]
synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie]
synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in stress response to cadmium ion" RELATED [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase II promoter involved in response to cadmium ion stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase II promoter involved in stress response to cadmium ion" EXACT [GOC:TermGenie]
synonym: "upregulation of global transcription from RNA polymerase II promoter involved in response to cadmium ion stress" RELATED [GOC:TermGenie]
synonym: "upregulation of global transcription from RNA polymerase II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie]
synonym: "upregulation of global transcription from RNA polymerase II promoter involved in stress response to cadmium ion" RELATED [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase II promoter involved in response to cadmium ion stress" EXACT [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase II promoter involved in stress response to cadmium ion" EXACT [GOC:TermGenie]
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
intersection_of: part_of GO:1990170 ! stress response to cadmium ion
relationship: part_of GO:1990170 ! stress response to cadmium ion
created_by: kmv
creation_date: 2014-04-14T18:03:42Z

[Term]
id: GO:1902902
name: negative regulation of autophagosome assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of autophagosome assembly." [GO_REF:0000058, GOC:als, GOC:autophagy, GOC:TermGenie, PMID:21975012]
synonym: "down regulation of autophagic vacuole assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of autophagic vacuole formation" RELATED [GOC:TermGenie]
synonym: "down regulation of autophagosome biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of autophagosome formation" EXACT [GOC:TermGenie]
synonym: "down regulation of PAS formation" NARROW [GOC:TermGenie]
synonym: "down-regulation of autophagic vacuole assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of autophagic vacuole formation" RELATED [GOC:TermGenie]
synonym: "down-regulation of autophagosome biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of autophagosome formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of PAS formation" NARROW [GOC:TermGenie]
synonym: "downregulation of autophagic vacuole assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of autophagic vacuole formation" RELATED [GOC:TermGenie]
synonym: "downregulation of autophagosome biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of autophagosome formation" EXACT [GOC:TermGenie]
synonym: "downregulation of PAS formation" NARROW [GOC:TermGenie]
synonym: "inhibition of autophagic vacuole assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of autophagic vacuole formation" RELATED [GOC:TermGenie]
synonym: "inhibition of autophagosome biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of autophagosome formation" NARROW [GOC:TermGenie]
synonym: "inhibition of PAS formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of autophagic vacuole assembly" EXACT [GOC:autophagy]
synonym: "negative regulation of autophagic vacuole formation" RELATED [GOC:TermGenie]
synonym: "negative regulation of autophagosome biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of autophagosome formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of PAS formation" NARROW [GOC:TermGenie]
is_a: GO:0016242 ! negative regulation of macroautophagy
is_a: GO:1902116 ! negative regulation of organelle assembly
is_a: GO:2000785 ! regulation of autophagosome assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000045 ! autophagosome assembly
relationship: negatively_regulates GO:0000045 ! autophagosome assembly
created_by: als
creation_date: 2014-04-15T10:37:40Z

[Term]
id: GO:1902903
name: regulation of fibril organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fibril organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388]
comment: HSPA8, human, P11142 in PMID:23921388 inferred from direct assay to negatively regulate fibrillation of alpha-Syn in vitro
synonym: "regulation of fibril organisation" EXACT [GOC:TermGenie]
is_a: GO:1903053 ! regulation of extracellular matrix organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097435 ! fibril organization
relationship: regulates GO:0097435 ! fibril organization
created_by: rl
creation_date: 2014-04-15T16:46:36Z

[Term]
id: GO:1902904
name: negative regulation of fibril organization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of fibril organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388]
comment: HSPA8, human, P11142 in PMID:23921388 inferred from direct assay to negatively regulate fibrillation of alpha-Syn in vitro
synonym: "down regulation of fibril organisation" EXACT [GOC:TermGenie]
synonym: "down regulation of fibril organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of fibril organisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of fibril organization" EXACT [GOC:TermGenie]
synonym: "downregulation of fibril organisation" EXACT [GOC:TermGenie]
synonym: "downregulation of fibril organization" EXACT [GOC:TermGenie]
synonym: "inhibition of fibril organisation" NARROW [GOC:TermGenie]
synonym: "inhibition of fibril organization" NARROW [GOC:TermGenie]
synonym: "negative regulation of fibril organisation" EXACT [GOC:TermGenie]
is_a: GO:1902903 ! regulation of fibril organization
is_a: GO:1903054 ! negative regulation of extracellular matrix organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097435 ! fibril organization
relationship: negatively_regulates GO:0097435 ! fibril organization
created_by: rl
creation_date: 2014-04-15T16:46:42Z

[Term]
id: GO:1902905
name: positive regulation of fibril organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of fibril organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388]
comment: HSPA8, human, P11142 in PMID:23921388 inferred from direct assay to negatively regulate fibrillation of alpha-Syn in vitro
synonym: "activation of fibril organisation" NARROW [GOC:TermGenie]
synonym: "activation of fibril organization" NARROW [GOC:TermGenie]
synonym: "positive regulation of fibril organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of fibril organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of fibril organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of fibril organisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of fibril organization" EXACT [GOC:TermGenie]
synonym: "upregulation of fibril organisation" EXACT [GOC:TermGenie]
synonym: "upregulation of fibril organization" EXACT [GOC:TermGenie]
is_a: GO:1902903 ! regulation of fibril organization
is_a: GO:1903055 ! positive regulation of extracellular matrix organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097435 ! fibril organization
relationship: positively_regulates GO:0097435 ! fibril organization
created_by: rl
creation_date: 2014-04-15T16:46:48Z

[Term]
id: GO:1902906
name: proteasome storage granule assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a proteasome storage granule." [GO_REF:0000079, GOC:di, GOC:TermGenie, PMID:23690178]
synonym: "proteasome storage granule formation" EXACT [GOC:TermGenie]
synonym: "PSG assembly" EXACT [GOC:TermGenie]
synonym: "PSG formation" EXACT [GOC:TermGenie]
is_a: GO:0043248 ! proteasome assembly
created_by: di
creation_date: 2014-04-16T01:59:41Z

[Term]
id: GO:1902907
name: proteasome storage granule disassembly
namespace: biological_process
def: "The disaggregation of a proteasome storage granule into its constituent components." [GO_REF:0000079, GOC:di, GOC:TermGenie, PMID:23690178]
synonym: "PSG disassembly" EXACT [GOC:TermGenie]
is_a: GO:1903009 ! proteasome complex disassembly
created_by: di
creation_date: 2014-04-16T01:59:47Z

[Term]
id: GO:1902908
name: regulation of melanosome transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of melanosome transport." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23334344]
is_a: GO:0051049 ! regulation of transport
is_a: GO:0060341 ! regulation of cellular localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032402 ! melanosome transport
relationship: regulates GO:0032402 ! melanosome transport
created_by: als
creation_date: 2014-04-17T11:40:16Z

[Term]
id: GO:1902909
name: negative regulation of melanosome transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of melanosome transport." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23334344]
synonym: "down regulation of melanosome transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of melanosome transport" EXACT [GOC:TermGenie]
synonym: "downregulation of melanosome transport" EXACT [GOC:TermGenie]
synonym: "inhibition of melanosome transport" NARROW [GOC:TermGenie]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:1902908 ! regulation of melanosome transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032402 ! melanosome transport
relationship: negatively_regulates GO:0032402 ! melanosome transport
created_by: als
creation_date: 2014-04-17T11:40:28Z

[Term]
id: GO:1902910
name: positive regulation of melanosome transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of melanosome transport." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23334344]
synonym: "activation of melanosome transport" NARROW [GOC:TermGenie]
synonym: "up regulation of melanosome transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of melanosome transport" EXACT [GOC:TermGenie]
synonym: "upregulation of melanosome transport" EXACT [GOC:TermGenie]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:1902908 ! regulation of melanosome transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032402 ! melanosome transport
relationship: positively_regulates GO:0032402 ! melanosome transport
created_by: als
creation_date: 2014-04-17T11:40:34Z

[Term]
id: GO:1902911
name: protein kinase complex
namespace: cellular_component
def: "A protein complex which is capable of protein kinase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:24606918]
comment: An example of this is PKM2 in human (P14618) in PMID:24606918 (inferred from direct assay).
is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups
created_by: bhm
creation_date: 2014-04-17T13:52:40Z

[Term]
id: GO:1902912
name: pyruvate kinase complex
namespace: cellular_component
def: "A protein complex which is capable of pyruvate kinase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:24606918]
comment: An example of this is PKM2 in human (P14618) in PMID:24606918 (inferred from direct assay).
is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups
created_by: bhm
creation_date: 2014-04-17T14:11:41Z

[Term]
id: GO:1902913
name: positive regulation of neuroepithelial cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neuroepithelial cell differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16916506]
synonym: "activation of neuroepithelial cell differentiation" NARROW [GOC:TermGenie]
synonym: "up regulation of neuroepithelial cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of neuroepithelial cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of neuroepithelial cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0030858 ! positive regulation of epithelial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060563 ! neuroepithelial cell differentiation
relationship: positively_regulates GO:0060563 ! neuroepithelial cell differentiation
created_by: mr
creation_date: 2014-04-18T21:06:42Z

[Term]
id: GO:1902914
name: regulation of protein polyubiquitination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein polyubiquitination." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:23645667]
synonym: "regulation of polyubiquitin" RELATED [GOC:TermGenie]
synonym: "regulation of protein polyubiquitinylation" EXACT [GOC:TermGenie]
synonym: "regulation of protein polyubiquitylation" EXACT [GOC:TermGenie]
is_a: GO:0031396 ! regulation of protein ubiquitination
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000209 ! protein polyubiquitination
relationship: regulates GO:0000209 ! protein polyubiquitination
created_by: di
creation_date: 2014-04-18T22:09:52Z

[Term]
id: GO:1902915
name: negative regulation of protein polyubiquitination
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein polyubiquitination." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:23645667]
synonym: "down regulation of polyubiquitin" RELATED [GOC:TermGenie]
synonym: "down regulation of protein polyubiquitination" EXACT [GOC:TermGenie]
synonym: "down regulation of protein polyubiquitinylation" EXACT [GOC:TermGenie]
synonym: "down regulation of protein polyubiquitylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of polyubiquitin" RELATED [GOC:TermGenie]
synonym: "down-regulation of protein polyubiquitination" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein polyubiquitinylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein polyubiquitylation" EXACT [GOC:TermGenie]
synonym: "downregulation of polyubiquitin" RELATED [GOC:TermGenie]
synonym: "downregulation of protein polyubiquitination" EXACT [GOC:TermGenie]
synonym: "downregulation of protein polyubiquitinylation" EXACT [GOC:TermGenie]
synonym: "downregulation of protein polyubiquitylation" EXACT [GOC:TermGenie]
synonym: "inhibition of polyubiquitin" RELATED [GOC:TermGenie]
synonym: "inhibition of protein polyubiquitination" NARROW [GOC:TermGenie]
synonym: "inhibition of protein polyubiquitinylation" NARROW [GOC:TermGenie]
synonym: "inhibition of protein polyubiquitylation" NARROW [GOC:TermGenie]
synonym: "negative regulation of polyubiquitin" RELATED [GOC:TermGenie]
synonym: "negative regulation of protein polyubiquitinylation" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein polyubiquitylation" EXACT [GOC:TermGenie]
is_a: GO:0031397 ! negative regulation of protein ubiquitination
is_a: GO:1902914 ! regulation of protein polyubiquitination
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000209 ! protein polyubiquitination
relationship: negatively_regulates GO:0000209 ! protein polyubiquitination
created_by: di
creation_date: 2014-04-18T22:09:58Z

[Term]
id: GO:1902916
name: positive regulation of protein polyubiquitination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein polyubiquitination." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:23645667]
synonym: "activation of polyubiquitin" RELATED [GOC:TermGenie]
synonym: "activation of protein polyubiquitination" NARROW [GOC:TermGenie]
synonym: "activation of protein polyubiquitinylation" NARROW [GOC:TermGenie]
synonym: "activation of protein polyubiquitylation" NARROW [GOC:TermGenie]
synonym: "positive regulation of polyubiquitin" RELATED [GOC:TermGenie]
synonym: "positive regulation of protein polyubiquitinylation" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein polyubiquitylation" EXACT [GOC:TermGenie]
synonym: "up regulation of polyubiquitin" RELATED [GOC:TermGenie]
synonym: "up regulation of protein polyubiquitination" EXACT [GOC:TermGenie]
synonym: "up regulation of protein polyubiquitinylation" EXACT [GOC:TermGenie]
synonym: "up regulation of protein polyubiquitylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of polyubiquitin" RELATED [GOC:TermGenie]
synonym: "up-regulation of protein polyubiquitination" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein polyubiquitinylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein polyubiquitylation" EXACT [GOC:TermGenie]
synonym: "upregulation of polyubiquitin" RELATED [GOC:TermGenie]
synonym: "upregulation of protein polyubiquitination" EXACT [GOC:TermGenie]
synonym: "upregulation of protein polyubiquitinylation" EXACT [GOC:TermGenie]
synonym: "upregulation of protein polyubiquitylation" EXACT [GOC:TermGenie]
is_a: GO:0031398 ! positive regulation of protein ubiquitination
is_a: GO:1902914 ! regulation of protein polyubiquitination
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000209 ! protein polyubiquitination
relationship: positively_regulates GO:0000209 ! protein polyubiquitination
created_by: di
creation_date: 2014-04-18T22:10:04Z

[Term]
id: GO:1902917
name: positive regulation of mating projection assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mating projection assembly." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:12455985]
synonym: "activation of mating projection assembly" NARROW [GOC:TermGenie]
synonym: "activation of mating projection biogenesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of mating projection biogenesis" RELATED [GOC:TermGenie]
synonym: "up regulation of mating projection assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of mating projection biogenesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of mating projection assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of mating projection biogenesis" RELATED [GOC:TermGenie]
synonym: "upregulation of mating projection assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of mating projection biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0031139 ! positive regulation of conjugation with cellular fusion
is_a: GO:0031346 ! positive regulation of cell projection organization
is_a: GO:0031383 ! regulation of mating projection assembly
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:0051094 ! positive regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0031382 ! mating projection assembly
relationship: positively_regulates GO:0031382 ! mating projection assembly
created_by: di
creation_date: 2014-04-20T11:18:03Z

[Term]
id: GO:1902918
name: poly(5-hydroxyvalerate) metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving poly(5-hydroxyvalerate)." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:21705209]
synonym: "poly(5-hydroxyvalerate) metabolism" EXACT [GOC:TermGenie]
is_a: GO:1902920 ! poly(hydroxyvalerate) metabolic process
created_by: tt
creation_date: 2014-04-21T18:47:06Z

[Term]
id: GO:1902919
name: poly(5-hydroxyvalerate) biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of poly(5-hydroxyvalerate)." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:21705209]
synonym: "poly(5-hydroxyvalerate) anabolism" EXACT [GOC:TermGenie]
synonym: "poly(5-hydroxyvalerate) biosynthesis" EXACT [GOC:TermGenie]
synonym: "poly(5-hydroxyvalerate) formation" EXACT [GOC:TermGenie]
synonym: "poly(5-hydroxyvalerate) synthesis" EXACT [GOC:TermGenie]
is_a: GO:1902918 ! poly(5-hydroxyvalerate) metabolic process
is_a: GO:1902921 ! poly(hydroxyvalerate) biosynthetic process
created_by: tt
creation_date: 2014-04-21T18:47:12Z

[Term]
id: GO:1902920
name: poly(hydroxyvalerate) metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving poly(hydroxyvalerate)." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:21705209]
synonym: "poly(hydroxyvalerate) metabolism" EXACT [GOC:TermGenie]
is_a: GO:1901440 ! poly(hydroxyalkanoate) metabolic process
created_by: tt
creation_date: 2014-04-21T19:12:32Z

[Term]
id: GO:1902921
name: poly(hydroxyvalerate) biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of poly(hydroxyvalerate)." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:21705209]
synonym: "poly(hydroxyvalerate) anabolism" EXACT [GOC:TermGenie]
synonym: "poly(hydroxyvalerate) biosynthesis" EXACT [GOC:TermGenie]
synonym: "poly(hydroxyvalerate) formation" EXACT [GOC:TermGenie]
synonym: "poly(hydroxyvalerate) synthesis" EXACT [GOC:TermGenie]
is_a: GO:1901441 ! poly(hydroxyalkanoate) biosynthetic process
is_a: GO:1902920 ! poly(hydroxyvalerate) metabolic process
created_by: tt
creation_date: 2014-04-21T19:12:38Z

[Term]
id: GO:1902922
name: poly(3-hydroxyvalerate) metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving poly(3-hydroxyvalerate)." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:21705209]
synonym: "poly(3-hydroxyvalerate) metabolism" EXACT [GOC:TermGenie]
is_a: GO:1902920 ! poly(hydroxyvalerate) metabolic process
created_by: tt
creation_date: 2014-04-21T19:13:56Z

[Term]
id: GO:1902923
name: poly(3-hydroxyvalerate) biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of poly(3-hydroxyvalerate)." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:21705209]
synonym: "poly(3-hydroxyvalerate) anabolism" EXACT [GOC:TermGenie]
synonym: "poly(3-hydroxyvalerate) biosynthesis" EXACT [GOC:TermGenie]
synonym: "poly(3-hydroxyvalerate) formation" EXACT [GOC:TermGenie]
synonym: "poly(3-hydroxyvalerate) synthesis" EXACT [GOC:TermGenie]
is_a: GO:1902921 ! poly(hydroxyvalerate) biosynthetic process
is_a: GO:1902922 ! poly(3-hydroxyvalerate) metabolic process
created_by: tt
creation_date: 2014-04-21T19:14:02Z

[Term]
id: GO:1902924
name: poly(hydroxyalkanoate) biosynthetic process from glucose
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of poly(hydroxyalkanoate) from glucose." [GO_REF:0000092, GOC:mengo_curators, GOC:TermGenie, PMID:24425304]
synonym: "poly(hydroxyalkanoate) anabolism from glucose" EXACT [GOC:TermGenie]
synonym: "poly(hydroxyalkanoate) biosynthesis from glucose" EXACT [GOC:TermGenie]
synonym: "poly(hydroxyalkanoate) formation from glucose" EXACT [GOC:TermGenie]
synonym: "poly(hydroxyalkanoate) synthesis from glucose" EXACT [GOC:TermGenie]
is_a: GO:0006006 ! glucose metabolic process
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:1901441 ! poly(hydroxyalkanoate) biosynthetic process
created_by: tt
creation_date: 2014-04-21T22:49:07Z

[Term]
id: GO:1902925
name: poly(hydroxyalkanoate) biosynthetic process from fatty acid
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of poly(hydroxyalkanoate) from fatty acid." [GO_REF:0000092, GOC:mengo_curators, GOC:TermGenie, PMID:21129764]
synonym: "poly(hydroxyalkanoate) anabolism from fatty acid" EXACT [GOC:TermGenie]
synonym: "poly(hydroxyalkanoate) biosynthesis from fatty acid" EXACT [GOC:TermGenie]
synonym: "poly(hydroxyalkanoate) formation from fatty acid" EXACT [GOC:TermGenie]
synonym: "poly(hydroxyalkanoate) synthesis from fatty acid" EXACT [GOC:TermGenie]
is_a: GO:0006631 ! fatty acid metabolic process
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:1901441 ! poly(hydroxyalkanoate) biosynthetic process
created_by: tt
creation_date: 2014-04-21T22:53:59Z

[Term]
id: GO:1902926
name: inulin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving inulin." [GO_REF:0000068, GOC:TermGenie, PMID:23104410]
comment: SUC2 in S. cerevisiae strain JZ1C in PMID:23104410.
synonym: "inulin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0010145 ! fructan metabolic process
created_by: se
creation_date: 2014-04-21T23:54:33Z

[Term]
id: GO:1902927
name: inulin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of inulin." [GO_REF:0000068, GOC:TermGenie, PMID:23104410]
comment: SUC2 in S. cerevisiae strain JZ1C in PMID:23104410.
synonym: "inulin breakdown" EXACT [GOC:TermGenie]
synonym: "inulin catabolism" EXACT [GOC:TermGenie]
synonym: "inulin degradation" EXACT [GOC:TermGenie]
is_a: GO:0010147 ! fructan catabolic process
is_a: GO:1902926 ! inulin metabolic process
created_by: se
creation_date: 2014-04-21T23:54:45Z

[Term]
id: GO:1902928
name: inulin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of inulin." [GO_REF:0000068, GOC:TermGenie, PMID:23104410]
comment: SUC2 in S. cerevisiae strain JZ1C in PMID:23104410.
synonym: "inulin anabolism" EXACT [GOC:TermGenie]
synonym: "inulin biosynthesis" EXACT [GOC:TermGenie]
synonym: "inulin formation" EXACT [GOC:TermGenie]
synonym: "inulin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010146 ! fructan biosynthetic process
is_a: GO:1902926 ! inulin metabolic process
created_by: se
creation_date: 2014-04-21T23:54:51Z

[Term]
id: GO:1902929
name: plasma membrane of growing cell tip
namespace: cellular_component
def: "Any plasma membrane part that is part of a growing cell tip." [GO_REF:0000064, GOC:TermGenie, PMID:17085965]
synonym: "growing cell tip plasma membrane part" EXACT [GOC:TermGenie]
synonym: "plasma membrane part of growing cell end" EXACT [GOC:TermGenie]
synonym: "plasma membrane part of growing cell tip" EXACT [GOC:TermGenie]
is_a: GO:0044459 ! plasma membrane part
intersection_of: GO:0044459 ! plasma membrane part
intersection_of: part_of GO:0035838 ! growing cell tip
relationship: part_of GO:0035838 ! growing cell tip
created_by: mah
creation_date: 2014-04-22T16:02:06Z

[Term]
id: GO:1902930
name: regulation of alcohol biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of alcohol biosynthetic process." [GO_REF:0000058, GOC:mengo_curators, GOC:TermGenie, PMID:23332010]
synonym: "regulation of alcohol anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of alcohol biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of alcohol formation" EXACT [GOC:TermGenie]
synonym: "regulation of alcohol synthesis" EXACT [GOC:TermGenie]
synonym: "regulation of solventogenesis" BROAD []
is_a: GO:0009889 ! regulation of biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0046165 ! alcohol biosynthetic process
relationship: regulates GO:0046165 ! alcohol biosynthetic process
created_by: tt
creation_date: 2014-04-22T21:55:03Z

[Term]
id: GO:1902931
name: negative regulation of alcohol biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of alcohol biosynthetic process." [GO_REF:0000058, GOC:mengo_curators, GOC:TermGenie, PMID:23332010]
synonym: "down regulation of alcohol anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of alcohol biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of alcohol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of alcohol formation" EXACT [GOC:TermGenie]
synonym: "down regulation of alcohol synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of alcohol anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of alcohol biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of alcohol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of alcohol formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of alcohol synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of alcohol anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of alcohol biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of alcohol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of alcohol formation" EXACT [GOC:TermGenie]
synonym: "downregulation of alcohol synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of alcohol anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of alcohol biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of alcohol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of alcohol formation" NARROW [GOC:TermGenie]
synonym: "inhibition of alcohol synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of alcohol anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of alcohol biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of alcohol formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of alcohol synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of solventogenesis" BROAD []
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:1902930 ! regulation of alcohol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0046165 ! alcohol biosynthetic process
relationship: negatively_regulates GO:0046165 ! alcohol biosynthetic process
created_by: tt
creation_date: 2014-04-22T21:55:13Z

[Term]
id: GO:1902932
name: positive regulation of alcohol biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of alcohol biosynthetic process." [GO_REF:0000058, GOC:mengo_curators, GOC:TermGenie, PMID:23332010]
synonym: "activation of alcohol anabolism" NARROW [GOC:TermGenie]
synonym: "activation of alcohol biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of alcohol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of alcohol formation" NARROW [GOC:TermGenie]
synonym: "activation of alcohol synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of alcohol anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of alcohol biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of alcohol formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of alcohol synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of solventogenesis" BROAD []
synonym: "up regulation of alcohol anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of alcohol biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of alcohol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of alcohol formation" EXACT [GOC:TermGenie]
synonym: "up regulation of alcohol synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of alcohol anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of alcohol biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of alcohol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of alcohol formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of alcohol synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of alcohol anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of alcohol biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of alcohol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of alcohol formation" EXACT [GOC:TermGenie]
synonym: "upregulation of alcohol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:1902930 ! regulation of alcohol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0046165 ! alcohol biosynthetic process
relationship: positively_regulates GO:0046165 ! alcohol biosynthetic process
created_by: tt
creation_date: 2014-04-22T21:55:19Z

[Term]
id: GO:1902933
name: isopentenol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving isopentenol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:17693564]
synonym: "isopentenol metabolism" EXACT [GOC:TermGenie]
is_a: GO:1901615 ! organic hydroxy compound metabolic process
created_by: tt
creation_date: 2014-04-24T16:51:35Z

[Term]
id: GO:1902934
name: isopentenol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of isopentenol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:17693564]
synonym: "isopentenol anabolism" EXACT [GOC:TermGenie]
synonym: "isopentenol biosynthesis" EXACT [GOC:TermGenie]
synonym: "isopentenol formation" EXACT [GOC:TermGenie]
synonym: "isopentenol synthesis" EXACT [GOC:TermGenie]
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process
is_a: GO:1902933 ! isopentenol metabolic process
created_by: tt
creation_date: 2014-04-24T16:51:42Z

[Term]
id: GO:1902935
name: protein localization to septin ring
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a septin ring." [GO_REF:0000087, GOC:TermGenie, PMID:16325501]
synonym: "protein localisation in septin ring" EXACT [GOC:TermGenie]
synonym: "protein localisation to septin ring" EXACT [GOC:TermGenie]
synonym: "protein localization in septin ring" EXACT [GOC:TermGenie]
is_a: GO:0044380 ! protein localization to cytoskeleton
is_a: GO:0072697 ! protein localization to cell cortex
created_by: mah
creation_date: 2014-04-25T13:08:17Z

[Term]
id: GO:1902936
name: phosphatidylinositol bisphosphate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with phosphatidylinositol bisphosphate." [GO_REF:0000067, GOC:bhm, GOC:TermGenie, PMID:18690034]
comment: An example of this is KCNJ2 in human (P63252) in PMID:18690034 (inferred from direct assay)
is_a: GO:1901981 ! phosphatidylinositol phosphate binding
created_by: bhm
creation_date: 2014-04-25T15:14:12Z

[Term]
id: GO:1902937
name: inward rectifier potassium channel complex
namespace: cellular_component
def: "A protein complex which is capable of inward rectifier potassium channel activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:16834334]
comment: An example of this is Kcnj2 in mouse (P35561) in PMID:16834334 (inferred from direct assay).
is_a: GO:0008076 ! voltage-gated potassium channel complex
is_a: GO:0098802 ! plasma membrane receptor complex
created_by: bhm
creation_date: 2014-04-25T15:18:41Z

[Term]
id: GO:1902938
name: regulation of intracellular calcium activated chloride channel activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of intracellular calcium activated chloride channel activity." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:22946059]
is_a: GO:0010359 ! regulation of anion channel activity
is_a: GO:1903795 ! regulation of inorganic anion transmembrane transport
is_a: GO:2001225 ! regulation of chloride transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0005229 ! intracellular calcium activated chloride channel activity
relationship: regulates GO:0005229 ! intracellular calcium activated chloride channel activity
created_by: als
creation_date: 2014-04-28T08:49:08Z

[Term]
id: GO:1902939
name: negative regulation of intracellular calcium activated chloride channel activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of intracellular calcium activated chloride channel activity." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:22946059]
synonym: "down regulation of intracellular calcium activated chloride channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of intracellular calcium activated chloride channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of intracellular calcium activated chloride channel activity" EXACT [GOC:TermGenie]
synonym: "inhibition of intracellular calcium activated chloride channel activity" NARROW [GOC:TermGenie]
is_a: GO:0010360 ! negative regulation of anion channel activity
is_a: GO:1902938 ! regulation of intracellular calcium activated chloride channel activity
is_a: GO:1903796 ! negative regulation of inorganic anion transmembrane transport
is_a: GO:2001226 ! negative regulation of chloride transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0005229 ! intracellular calcium activated chloride channel activity
relationship: negatively_regulates GO:0005229 ! intracellular calcium activated chloride channel activity
created_by: als
creation_date: 2014-04-28T08:49:14Z

[Term]
id: GO:1902940
name: positive regulation of intracellular calcium activated chloride channel activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of intracellular calcium activated chloride channel activity." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:22946059]
synonym: "activation of intracellular calcium activated chloride channel activity" NARROW [GOC:TermGenie]
synonym: "up regulation of intracellular calcium activated chloride channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of intracellular calcium activated chloride channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of intracellular calcium activated chloride channel activity" EXACT [GOC:TermGenie]
is_a: GO:1901529 ! positive regulation of anion channel activity
is_a: GO:1902938 ! regulation of intracellular calcium activated chloride channel activity
is_a: GO:1903797 ! positive regulation of inorganic anion transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0005229 ! intracellular calcium activated chloride channel activity
relationship: positively_regulates GO:0005229 ! intracellular calcium activated chloride channel activity
created_by: als
creation_date: 2014-04-28T08:49:20Z

[Term]
id: GO:1902941
name: regulation of voltage-gated chloride channel activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of voltage-gated chloride channel activity." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:22006324]
synonym: "regulation of voltage gated chloride channel activity" EXACT [GOC:TermGenie]
synonym: "regulation of voltage-dependent chloride channel activity" EXACT [GOC:TermGenie]
is_a: GO:0010359 ! regulation of anion channel activity
is_a: GO:1903795 ! regulation of inorganic anion transmembrane transport
is_a: GO:2001225 ! regulation of chloride transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0005247 ! voltage-gated chloride channel activity
relationship: regulates GO:0005247 ! voltage-gated chloride channel activity
created_by: als
creation_date: 2014-04-28T08:55:31Z

[Term]
id: GO:1902942
name: negative regulation of voltage-gated chloride channel activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated chloride channel activity." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:22006324]
synonym: "down regulation of voltage gated chloride channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of voltage-dependent chloride channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of voltage-gated chloride channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of voltage gated chloride channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of voltage-dependent chloride channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of voltage-gated chloride channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of voltage gated chloride channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of voltage-dependent chloride channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of voltage-gated chloride channel activity" EXACT [GOC:TermGenie]
synonym: "inhibition of voltage gated chloride channel activity" NARROW [GOC:TermGenie]
synonym: "inhibition of voltage-dependent chloride channel activity" NARROW [GOC:TermGenie]
synonym: "inhibition of voltage-gated chloride channel activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of voltage gated chloride channel activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of voltage-dependent chloride channel activity" EXACT [GOC:TermGenie]
is_a: GO:0010360 ! negative regulation of anion channel activity
is_a: GO:1902941 ! regulation of voltage-gated chloride channel activity
is_a: GO:1903796 ! negative regulation of inorganic anion transmembrane transport
is_a: GO:2001226 ! negative regulation of chloride transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0005247 ! voltage-gated chloride channel activity
relationship: negatively_regulates GO:0005247 ! voltage-gated chloride channel activity
created_by: als
creation_date: 2014-04-28T08:55:37Z

[Term]
id: GO:1902943
name: positive regulation of voltage-gated chloride channel activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of voltage-gated chloride channel activity." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:22006324]
synonym: "activation of voltage gated chloride channel activity" NARROW [GOC:TermGenie]
synonym: "activation of voltage-dependent chloride channel activity" NARROW [GOC:TermGenie]
synonym: "activation of voltage-gated chloride channel activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of voltage gated chloride channel activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of voltage-dependent chloride channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of voltage gated chloride channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of voltage-dependent chloride channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of voltage-gated chloride channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of voltage gated chloride channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of voltage-dependent chloride channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of voltage-gated chloride channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of voltage gated chloride channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of voltage-dependent chloride channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of voltage-gated chloride channel activity" EXACT [GOC:TermGenie]
is_a: GO:1901529 ! positive regulation of anion channel activity
is_a: GO:1902941 ! regulation of voltage-gated chloride channel activity
is_a: GO:1903797 ! positive regulation of inorganic anion transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0005247 ! voltage-gated chloride channel activity
relationship: positively_regulates GO:0005247 ! voltage-gated chloride channel activity
created_by: als
creation_date: 2014-04-28T08:55:43Z

[Term]
id: GO:1902944
name: aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
namespace: molecular_function
def: "Any aspartic-type endopeptidase activity that is involved in amyloid precursor protein catabolic process." [GO_REF:0000061, GOC:sjp, GOC:TermGenie, PMID:10206644, PMID:24577224]
synonym: "aspartate protease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie]
synonym: "aspartate protease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie]
synonym: "aspartate protease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie]
synonym: "aspartate protease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie]
synonym: "aspartate protease activity involved in APP catabolic process" NARROW [GOC:TermGenie]
synonym: "aspartate protease activity involved in APP catabolism" NARROW [GOC:TermGenie]
synonym: "aspartic endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "aspartic endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "aspartic endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "aspartic endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "aspartic endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "aspartic endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "aspartic protease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie]
synonym: "aspartic protease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie]
synonym: "aspartic protease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie]
synonym: "aspartic protease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie]
synonym: "aspartic protease activity involved in APP catabolic process" NARROW [GOC:TermGenie]
synonym: "aspartic protease activity involved in APP catabolism" NARROW [GOC:TermGenie]
synonym: "aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "aspartic-type endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "aspartic-type endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "aspartic-type endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "aspartyl protease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie]
synonym: "aspartyl protease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie]
synonym: "aspartyl protease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie]
synonym: "aspartyl protease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie]
synonym: "aspartyl protease activity involved in APP catabolic process" NARROW [GOC:TermGenie]
synonym: "aspartyl protease activity involved in APP catabolism" NARROW [GOC:TermGenie]
synonym: "carboxyl protease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie]
synonym: "carboxyl protease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie]
synonym: "carboxyl protease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie]
synonym: "carboxyl protease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie]
synonym: "carboxyl protease activity involved in APP catabolic process" NARROW [GOC:TermGenie]
synonym: "carboxyl protease activity involved in APP catabolism" NARROW [GOC:TermGenie]
is_a: GO:0004190 ! aspartic-type endopeptidase activity
intersection_of: GO:0004190 ! aspartic-type endopeptidase activity
intersection_of: part_of GO:0042987 ! amyloid precursor protein catabolic process
relationship: part_of GO:0042987 ! amyloid precursor protein catabolic process
created_by: sjp
creation_date: 2014-05-02T07:59:42Z

[Term]
id: GO:1902945
name: metalloendopeptidase activity involved in amyloid precursor protein catabolic process
namespace: molecular_function
def: "Any metalloendopeptidase activity that is involved in amyloid precursor protein catabolic process." [GO_REF:0000061, GOC:sjp, GOC:TermGenie, PMID:14598310, PMID:17855360]
synonym: "metalloendopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "metalloendopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "metalloendopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "metalloendopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "metalloendopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "metalloendoprotease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie]
synonym: "metalloendoprotease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie]
synonym: "metalloendoprotease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie]
synonym: "metalloendoprotease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie]
synonym: "metalloendoprotease activity involved in APP catabolic process" NARROW [GOC:TermGenie]
synonym: "metalloendoprotease activity involved in APP catabolism" NARROW [GOC:TermGenie]
synonym: "metalloendoproteinase activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie]
synonym: "metalloendoproteinase activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie]
synonym: "metalloendoproteinase activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie]
synonym: "metalloendoproteinase activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie]
synonym: "metalloendoproteinase activity involved in APP catabolic process" NARROW [GOC:TermGenie]
synonym: "metalloendoproteinase activity involved in APP catabolism" NARROW [GOC:TermGenie]
is_a: GO:0004222 ! metalloendopeptidase activity
intersection_of: GO:0004222 ! metalloendopeptidase activity
intersection_of: part_of GO:0042987 ! amyloid precursor protein catabolic process
relationship: part_of GO:0042987 ! amyloid precursor protein catabolic process
created_by: sjp
creation_date: 2014-05-02T08:13:04Z

[Term]
id: GO:1902946
name: protein localization to early endosome
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within an early endosome." [GO_REF:0000087, GOC:sjp, GOC:TermGenie, PMID:22621900]
synonym: "protein localisation in early endosome" EXACT [GOC:TermGenie]
synonym: "protein localisation to early endosome" EXACT [GOC:TermGenie]
synonym: "protein localization in early endosome" EXACT [GOC:TermGenie]
is_a: GO:0036010 ! protein localization to endosome
created_by: sjp
creation_date: 2014-05-02T08:26:00Z

[Term]
id: GO:1902947
name: regulation of tau-protein kinase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tau-protein kinase activity." [GO_REF:0000059, GOC:sjp, GOC:TermGenie, PMID:15897157, PMID:22986780]
synonym: "regulation of [Tau protein] kinase activity" EXACT [GOC:TermGenie]
synonym: "regulation of ATP:tau-protein O-phosphotransferase activity" BROAD [GOC:TermGenie]
synonym: "regulation of brain protein kinase PK40erk activity" NARROW [GOC:TermGenie]
synonym: "regulation of cdk5/p20" RELATED [GOC:TermGenie]
synonym: "regulation of CDK5/p23" RELATED [GOC:TermGenie]
synonym: "regulation of glycogen synthase kinase-3beta activity" EXACT [GOC:TermGenie]
synonym: "regulation of GSK" RELATED [GOC:TermGenie]
synonym: "regulation of protein tau kinase activity" EXACT [GOC:TermGenie]
synonym: "regulation of STK31" RELATED [GOC:TermGenie]
synonym: "regulation of tau kinase activity" EXACT [GOC:TermGenie]
synonym: "regulation of tau protein kinase activity" EXACT [GOC:TermGenie]
synonym: "regulation of tau-protein kinase I activity" NARROW [GOC:TermGenie]
synonym: "regulation of tau-protein kinase II activity" NARROW [GOC:TermGenie]
synonym: "regulation of tau-tubulin kinase activity" NARROW [GOC:TermGenie]
synonym: "regulation of TPK" RELATED [GOC:TermGenie]
synonym: "regulation of TPK I" RELATED [GOC:TermGenie]
synonym: "regulation of TPK II" RELATED [GOC:TermGenie]
synonym: "regulation of TTK" RELATED [GOC:TermGenie]
is_a: GO:0045859 ! regulation of protein kinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050321 ! tau-protein kinase activity
relationship: regulates GO:0050321 ! tau-protein kinase activity
created_by: sjp
creation_date: 2014-05-02T08:43:27Z

[Term]
id: GO:1902948
name: negative regulation of tau-protein kinase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tau-protein kinase activity." [GO_REF:0000059, GOC:sjp, GOC:TermGenie, PMID:15897157, PMID:22986780]
synonym: "down regulation of [Tau protein] kinase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of brain protein kinase PK40erk activity" NARROW [GOC:TermGenie]
synonym: "down regulation of cdk5/p20" RELATED [GOC:TermGenie]
synonym: "down regulation of CDK5/p23" RELATED [GOC:TermGenie]
synonym: "down regulation of glycogen synthase kinase-3beta activity" EXACT [GOC:TermGenie]
synonym: "down regulation of GSK" RELATED [GOC:TermGenie]
synonym: "down regulation of protein tau kinase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of STK31" RELATED [GOC:TermGenie]
synonym: "down regulation of tau kinase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of tau protein kinase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of tau-protein kinase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of tau-protein kinase I activity" NARROW [GOC:TermGenie]
synonym: "down regulation of tau-protein kinase II activity" NARROW [GOC:TermGenie]
synonym: "down regulation of tau-tubulin kinase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of TPK" RELATED [GOC:TermGenie]
synonym: "down regulation of TPK I" RELATED [GOC:TermGenie]
synonym: "down regulation of TPK II" RELATED [GOC:TermGenie]
synonym: "down regulation of TTK" RELATED [GOC:TermGenie]
synonym: "down-regulation of [Tau protein] kinase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of brain protein kinase PK40erk activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of cdk5/p20" RELATED [GOC:TermGenie]
synonym: "down-regulation of CDK5/p23" RELATED [GOC:TermGenie]
synonym: "down-regulation of glycogen synthase kinase-3beta activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of GSK" RELATED [GOC:TermGenie]
synonym: "down-regulation of protein tau kinase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of STK31" RELATED [GOC:TermGenie]
synonym: "down-regulation of tau kinase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of tau protein kinase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of tau-protein kinase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of tau-protein kinase I activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of tau-protein kinase II activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of tau-tubulin kinase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of TPK" RELATED [GOC:TermGenie]
synonym: "down-regulation of TPK I" RELATED [GOC:TermGenie]
synonym: "down-regulation of TPK II" RELATED [GOC:TermGenie]
synonym: "down-regulation of TTK" RELATED [GOC:TermGenie]
synonym: "downregulation of [Tau protein] kinase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of brain protein kinase PK40erk activity" NARROW [GOC:TermGenie]
synonym: "downregulation of cdk5/p20" RELATED [GOC:TermGenie]
synonym: "downregulation of CDK5/p23" RELATED [GOC:TermGenie]
synonym: "downregulation of glycogen synthase kinase-3beta activity" EXACT [GOC:TermGenie]
synonym: "downregulation of GSK" RELATED [GOC:TermGenie]
synonym: "downregulation of protein tau kinase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of STK31" RELATED [GOC:TermGenie]
synonym: "downregulation of tau kinase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of tau protein kinase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of tau-protein kinase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of tau-protein kinase I activity" NARROW [GOC:TermGenie]
synonym: "downregulation of tau-protein kinase II activity" NARROW [GOC:TermGenie]
synonym: "downregulation of tau-tubulin kinase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of TPK" RELATED [GOC:TermGenie]
synonym: "downregulation of TPK I" RELATED [GOC:TermGenie]
synonym: "downregulation of TPK II" RELATED [GOC:TermGenie]
synonym: "downregulation of TTK" RELATED [GOC:TermGenie]
synonym: "inhibition of [Tau protein] kinase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of brain protein kinase PK40erk activity" NARROW [GOC:TermGenie]
synonym: "inhibition of cdk5/p20" RELATED [GOC:TermGenie]
synonym: "inhibition of CDK5/p23" RELATED [GOC:TermGenie]
synonym: "inhibition of glycogen synthase kinase-3beta activity" NARROW [GOC:TermGenie]
synonym: "inhibition of GSK" RELATED [GOC:TermGenie]
synonym: "inhibition of protein tau kinase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of STK31" RELATED [GOC:TermGenie]
synonym: "inhibition of tau kinase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of tau protein kinase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of tau-protein kinase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of tau-protein kinase I activity" NARROW [GOC:TermGenie]
synonym: "inhibition of tau-protein kinase II activity" NARROW [GOC:TermGenie]
synonym: "inhibition of tau-tubulin kinase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of TPK" RELATED [GOC:TermGenie]
synonym: "inhibition of TPK I" RELATED [GOC:TermGenie]
synonym: "inhibition of TPK II" RELATED [GOC:TermGenie]
synonym: "inhibition of TTK" RELATED [GOC:TermGenie]
synonym: "negative regulation of [Tau protein] kinase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of brain protein kinase PK40erk activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of cdk5/p20" RELATED [GOC:TermGenie]
synonym: "negative regulation of CDK5/p23" RELATED [GOC:TermGenie]
synonym: "negative regulation of glycogen synthase kinase-3beta activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of GSK" RELATED [GOC:TermGenie]
synonym: "negative regulation of protein tau kinase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of STK31" RELATED [GOC:TermGenie]
synonym: "negative regulation of tau kinase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of tau protein kinase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of tau-protein kinase I activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of tau-protein kinase II activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of tau-tubulin kinase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of TPK" RELATED [GOC:TermGenie]
synonym: "negative regulation of TPK I" RELATED [GOC:TermGenie]
synonym: "negative regulation of TPK II" RELATED [GOC:TermGenie]
synonym: "negative regulation of TTK" RELATED [GOC:TermGenie]
is_a: GO:0006469 ! negative regulation of protein kinase activity
is_a: GO:1902947 ! regulation of tau-protein kinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0050321 ! tau-protein kinase activity
relationship: negatively_regulates GO:0050321 ! tau-protein kinase activity
created_by: sjp
creation_date: 2014-05-02T08:43:32Z

[Term]
id: GO:1902949
name: positive regulation of tau-protein kinase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tau-protein kinase activity." [GO_REF:0000059, GOC:sjp, GOC:TermGenie, PMID:15897157, PMID:22986780]
synonym: "activation of [Tau protein] kinase activity" NARROW [GOC:TermGenie]
synonym: "activation of brain protein kinase PK40erk activity" NARROW [GOC:TermGenie]
synonym: "activation of cdk5/p20" RELATED [GOC:TermGenie]
synonym: "activation of CDK5/p23" RELATED [GOC:TermGenie]
synonym: "activation of glycogen synthase kinase-3beta activity" NARROW [GOC:TermGenie]
synonym: "activation of GSK" RELATED [GOC:TermGenie]
synonym: "activation of protein tau kinase activity" NARROW [GOC:TermGenie]
synonym: "activation of STK31" RELATED [GOC:TermGenie]
synonym: "activation of tau kinase activity" NARROW [GOC:TermGenie]
synonym: "activation of tau protein kinase activity" NARROW [GOC:TermGenie]
synonym: "activation of tau-protein kinase activity" NARROW [GOC:TermGenie]
synonym: "activation of tau-protein kinase I activity" NARROW [GOC:TermGenie]
synonym: "activation of tau-protein kinase II activity" NARROW [GOC:TermGenie]
synonym: "activation of tau-tubulin kinase activity" NARROW [GOC:TermGenie]
synonym: "activation of TPK" RELATED [GOC:TermGenie]
synonym: "activation of TPK I" RELATED [GOC:TermGenie]
synonym: "activation of TPK II" RELATED [GOC:TermGenie]
synonym: "activation of TTK" RELATED [GOC:TermGenie]
synonym: "positive regulation of [Tau protein] kinase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of brain protein kinase PK40erk activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of cdk5/p20" RELATED [GOC:TermGenie]
synonym: "positive regulation of CDK5/p23" RELATED [GOC:TermGenie]
synonym: "positive regulation of glycogen synthase kinase-3beta activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of GSK" RELATED [GOC:TermGenie]
synonym: "positive regulation of protein tau kinase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of STK31" RELATED [GOC:TermGenie]
synonym: "positive regulation of tau kinase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of tau protein kinase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of tau-protein kinase I activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of tau-protein kinase II activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of tau-tubulin kinase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of TPK" RELATED [GOC:TermGenie]
synonym: "positive regulation of TPK I" RELATED [GOC:TermGenie]
synonym: "positive regulation of TPK II" RELATED [GOC:TermGenie]
synonym: "positive regulation of TTK" RELATED [GOC:TermGenie]
synonym: "up regulation of [Tau protein] kinase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of brain protein kinase PK40erk activity" NARROW [GOC:TermGenie]
synonym: "up regulation of cdk5/p20" RELATED [GOC:TermGenie]
synonym: "up regulation of CDK5/p23" RELATED [GOC:TermGenie]
synonym: "up regulation of glycogen synthase kinase-3beta activity" EXACT [GOC:TermGenie]
synonym: "up regulation of GSK" RELATED [GOC:TermGenie]
synonym: "up regulation of protein tau kinase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of STK31" RELATED [GOC:TermGenie]
synonym: "up regulation of tau kinase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of tau protein kinase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of tau-protein kinase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of tau-protein kinase I activity" NARROW [GOC:TermGenie]
synonym: "up regulation of tau-protein kinase II activity" NARROW [GOC:TermGenie]
synonym: "up regulation of tau-tubulin kinase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of TPK" RELATED [GOC:TermGenie]
synonym: "up regulation of TPK I" RELATED [GOC:TermGenie]
synonym: "up regulation of TPK II" RELATED [GOC:TermGenie]
synonym: "up regulation of TTK" RELATED [GOC:TermGenie]
synonym: "up-regulation of [Tau protein] kinase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of brain protein kinase PK40erk activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of cdk5/p20" RELATED [GOC:TermGenie]
synonym: "up-regulation of CDK5/p23" RELATED [GOC:TermGenie]
synonym: "up-regulation of glycogen synthase kinase-3beta activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of GSK" RELATED [GOC:TermGenie]
synonym: "up-regulation of protein tau kinase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of STK31" RELATED [GOC:TermGenie]
synonym: "up-regulation of tau kinase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of tau protein kinase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of tau-protein kinase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of tau-protein kinase I activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of tau-protein kinase II activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of tau-tubulin kinase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of TPK" RELATED [GOC:TermGenie]
synonym: "up-regulation of TPK I" RELATED [GOC:TermGenie]
synonym: "up-regulation of TPK II" RELATED [GOC:TermGenie]
synonym: "up-regulation of TTK" RELATED [GOC:TermGenie]
synonym: "upregulation of [Tau protein] kinase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of brain protein kinase PK40erk activity" NARROW [GOC:TermGenie]
synonym: "upregulation of cdk5/p20" RELATED [GOC:TermGenie]
synonym: "upregulation of CDK5/p23" RELATED [GOC:TermGenie]
synonym: "upregulation of glycogen synthase kinase-3beta activity" EXACT [GOC:TermGenie]
synonym: "upregulation of GSK" RELATED [GOC:TermGenie]
synonym: "upregulation of protein tau kinase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of STK31" RELATED [GOC:TermGenie]
synonym: "upregulation of tau kinase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of tau protein kinase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of tau-protein kinase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of tau-protein kinase I activity" NARROW [GOC:TermGenie]
synonym: "upregulation of tau-protein kinase II activity" NARROW [GOC:TermGenie]
synonym: "upregulation of tau-tubulin kinase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of TPK" RELATED [GOC:TermGenie]
synonym: "upregulation of TPK I" RELATED [GOC:TermGenie]
synonym: "upregulation of TPK II" RELATED [GOC:TermGenie]
synonym: "upregulation of TTK" RELATED [GOC:TermGenie]
is_a: GO:0045860 ! positive regulation of protein kinase activity
is_a: GO:1902947 ! regulation of tau-protein kinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0050321 ! tau-protein kinase activity
relationship: positively_regulates GO:0050321 ! tau-protein kinase activity
created_by: sjp
creation_date: 2014-05-02T08:43:38Z

[Term]
id: GO:1902950
name: regulation of dendritic spine maintenance
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dendritic spine maintenance." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:24328732]
is_a: GO:0031344 ! regulation of cell projection organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097062 ! dendritic spine maintenance
relationship: regulates GO:0097062 ! dendritic spine maintenance
created_by: sjp
creation_date: 2014-05-02T08:48:47Z

[Term]
id: GO:1902951
name: negative regulation of dendritic spine maintenance
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic spine maintenance." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:24328732]
synonym: "down regulation of dendritic spine maintenance" EXACT [GOC:TermGenie]
synonym: "down-regulation of dendritic spine maintenance" EXACT [GOC:TermGenie]
synonym: "downregulation of dendritic spine maintenance" EXACT [GOC:TermGenie]
synonym: "inhibition of dendritic spine maintenance" NARROW [GOC:TermGenie]
is_a: GO:0031345 ! negative regulation of cell projection organization
is_a: GO:1902950 ! regulation of dendritic spine maintenance
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097062 ! dendritic spine maintenance
relationship: negatively_regulates GO:0097062 ! dendritic spine maintenance
created_by: sjp
creation_date: 2014-05-02T08:48:53Z

[Term]
id: GO:1902952
name: positive regulation of dendritic spine maintenance
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of dendritic spine maintenance." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:24328732]
synonym: "activation of dendritic spine maintenance" NARROW [GOC:TermGenie]
synonym: "up regulation of dendritic spine maintenance" EXACT [GOC:TermGenie]
synonym: "up-regulation of dendritic spine maintenance" EXACT [GOC:TermGenie]
synonym: "upregulation of dendritic spine maintenance" EXACT [GOC:TermGenie]
is_a: GO:0031346 ! positive regulation of cell projection organization
is_a: GO:1902950 ! regulation of dendritic spine maintenance
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097062 ! dendritic spine maintenance
relationship: positively_regulates GO:0097062 ! dendritic spine maintenance
created_by: sjp
creation_date: 2014-05-02T08:48:59Z

[Term]
id: GO:1902953
name: positive regulation of ER to Golgi vesicle-mediated transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ER to Golgi vesicle-mediated transport." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:17855360]
synonym: "activation of endoplasmic reticulum to Golgi transport" NARROW [GOC:TermGenie]
synonym: "activation of endoplasmic reticulum to Golgi vesicle-mediated transport" NARROW [GOC:TermGenie]
synonym: "activation of ER to Golgi transport" NARROW [GOC:TermGenie]
synonym: "activation of ER to Golgi vesicle-mediated transport" NARROW [GOC:TermGenie]
synonym: "activation of rough endoplasmic reticulum to cis-Golgi transport" NARROW [GOC:TermGenie]
synonym: "activation of rough endoplasmic reticulum to cis-Golgi vesicle-mediated transport" NARROW [GOC:TermGenie]
synonym: "activation of rough ER to cis-Golgi transport" NARROW [GOC:TermGenie]
synonym: "activation of rough ER to cis-Golgi vesicle-mediated transport" NARROW [GOC:TermGenie]
synonym: "positive regulation of endoplasmic reticulum to Golgi transport" EXACT [GOC:TermGenie]
synonym: "positive regulation of endoplasmic reticulum to Golgi vesicle-mediated transport" EXACT [GOC:TermGenie]
synonym: "positive regulation of ER to Golgi transport" EXACT [GOC:TermGenie]
synonym: "positive regulation of rough endoplasmic reticulum to cis-Golgi transport" EXACT [GOC:TermGenie]
synonym: "positive regulation of rough endoplasmic reticulum to cis-Golgi vesicle-mediated transport" EXACT [GOC:TermGenie]
synonym: "positive regulation of rough ER to cis-Golgi transport" EXACT [GOC:TermGenie]
synonym: "positive regulation of rough ER to cis-Golgi vesicle-mediated transport" EXACT [GOC:TermGenie]
synonym: "up regulation of endoplasmic reticulum to Golgi transport" EXACT [GOC:TermGenie]
synonym: "up regulation of endoplasmic reticulum to Golgi vesicle-mediated transport" EXACT [GOC:TermGenie]
synonym: "up regulation of ER to Golgi transport" EXACT [GOC:TermGenie]
synonym: "up regulation of ER to Golgi vesicle-mediated transport" EXACT [GOC:TermGenie]
synonym: "up regulation of rough endoplasmic reticulum to cis-Golgi transport" EXACT [GOC:TermGenie]
synonym: "up regulation of rough endoplasmic reticulum to cis-Golgi vesicle-mediated transport" EXACT [GOC:TermGenie]
synonym: "up regulation of rough ER to cis-Golgi transport" EXACT [GOC:TermGenie]
synonym: "up regulation of rough ER to cis-Golgi vesicle-mediated transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of endoplasmic reticulum to Golgi transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of endoplasmic reticulum to Golgi vesicle-mediated transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of ER to Golgi transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of ER to Golgi vesicle-mediated transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of rough endoplasmic reticulum to cis-Golgi transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of rough endoplasmic reticulum to cis-Golgi vesicle-mediated transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of rough ER to cis-Golgi transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of rough ER to cis-Golgi vesicle-mediated transport" EXACT [GOC:TermGenie]
synonym: "upregulation of endoplasmic reticulum to Golgi transport" EXACT [GOC:TermGenie]
synonym: "upregulation of endoplasmic reticulum to Golgi vesicle-mediated transport" EXACT [GOC:TermGenie]
synonym: "upregulation of ER to Golgi transport" EXACT [GOC:TermGenie]
synonym: "upregulation of ER to Golgi vesicle-mediated transport" EXACT [GOC:TermGenie]
synonym: "upregulation of rough endoplasmic reticulum to cis-Golgi transport" EXACT [GOC:TermGenie]
synonym: "upregulation of rough endoplasmic reticulum to cis-Golgi vesicle-mediated transport" EXACT [GOC:TermGenie]
synonym: "upregulation of rough ER to cis-Golgi transport" EXACT [GOC:TermGenie]
synonym: "upregulation of rough ER to cis-Golgi vesicle-mediated transport" EXACT [GOC:TermGenie]
is_a: GO:0060628 ! regulation of ER to Golgi vesicle-mediated transport
is_a: GO:1903651 ! positive regulation of cytoplasmic transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006888 ! ER to Golgi vesicle-mediated transport
relationship: positively_regulates GO:0006888 ! ER to Golgi vesicle-mediated transport
created_by: sjp
creation_date: 2014-05-02T08:59:18Z

[Term]
id: GO:1902954
name: regulation of early endosome to recycling endosome transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of early endosome to recycling endosome transport." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:22621900]
is_a: GO:0060627 ! regulation of vesicle-mediated transport
is_a: GO:1903335 ! regulation of vacuolar transport
is_a: GO:1903649 ! regulation of cytoplasmic transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061502 ! early endosome to recycling endosome transport
relationship: regulates GO:0061502 ! early endosome to recycling endosome transport
created_by: sjp
creation_date: 2014-05-02T09:06:23Z

[Term]
id: GO:1902955
name: positive regulation of early endosome to recycling endosome transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of early endosome to recycling endosome transport." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:22621900]
synonym: "activation of early endosome to recycling endosome transport" NARROW [GOC:TermGenie]
synonym: "up regulation of early endosome to recycling endosome transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of early endosome to recycling endosome transport" EXACT [GOC:TermGenie]
synonym: "upregulation of early endosome to recycling endosome transport" EXACT [GOC:TermGenie]
is_a: GO:1902954 ! regulation of early endosome to recycling endosome transport
is_a: GO:1903337 ! positive regulation of vacuolar transport
is_a: GO:1903651 ! positive regulation of cytoplasmic transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061502 ! early endosome to recycling endosome transport
relationship: positively_regulates GO:0061502 ! early endosome to recycling endosome transport
created_by: sjp
creation_date: 2014-05-02T09:06:29Z

[Term]
id: GO:1902956
name: regulation of mitochondrial electron transport, NADH to ubiquinone
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitochondrial electron transport, NADH to ubiquinone." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:23530063]
synonym: "regulation of complex I (NADH to ubiquinone)" RELATED [GOC:TermGenie]
synonym: "regulation of oxidative phosphorylation, NADH to ubiquinone" EXACT [GOC:TermGenie]
is_a: GO:0002082 ! regulation of oxidative phosphorylation
is_a: GO:0043457 ! regulation of cellular respiration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006120 ! mitochondrial electron transport, NADH to ubiquinone
relationship: regulates GO:0006120 ! mitochondrial electron transport, NADH to ubiquinone
created_by: dph
creation_date: 2014-05-02T15:30:12Z

[Term]
id: GO:1902957
name: negative regulation of mitochondrial electron transport, NADH to ubiquinone
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial electron transport, NADH to ubiquinone." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:23530063]
synonym: "down regulation of complex I (NADH to ubiquinone)" RELATED [GOC:TermGenie]
synonym: "down regulation of mitochondrial electron transport, NADH to ubiquinone" EXACT [GOC:TermGenie]
synonym: "down regulation of oxidative phosphorylation, NADH to ubiquinone" EXACT [GOC:TermGenie]
synonym: "down-regulation of complex I (NADH to ubiquinone)" RELATED [GOC:TermGenie]
synonym: "down-regulation of mitochondrial electron transport, NADH to ubiquinone" EXACT [GOC:TermGenie]
synonym: "down-regulation of oxidative phosphorylation, NADH to ubiquinone" EXACT [GOC:TermGenie]
synonym: "downregulation of complex I (NADH to ubiquinone)" RELATED [GOC:TermGenie]
synonym: "downregulation of mitochondrial electron transport, NADH to ubiquinone" EXACT [GOC:TermGenie]
synonym: "downregulation of oxidative phosphorylation, NADH to ubiquinone" EXACT [GOC:TermGenie]
synonym: "inhibition of complex I (NADH to ubiquinone)" RELATED [GOC:TermGenie]
synonym: "inhibition of mitochondrial electron transport, NADH to ubiquinone" NARROW [GOC:TermGenie]
synonym: "inhibition of oxidative phosphorylation, NADH to ubiquinone" NARROW [GOC:TermGenie]
synonym: "negative regulation of complex I (NADH to ubiquinone)" RELATED [GOC:TermGenie]
synonym: "negative regulation of oxidative phosphorylation, NADH to ubiquinone" EXACT [GOC:TermGenie]
is_a: GO:0090324 ! negative regulation of oxidative phosphorylation
is_a: GO:1901856 ! negative regulation of cellular respiration
is_a: GO:1902956 ! regulation of mitochondrial electron transport, NADH to ubiquinone
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006120 ! mitochondrial electron transport, NADH to ubiquinone
relationship: negatively_regulates GO:0006120 ! mitochondrial electron transport, NADH to ubiquinone
created_by: dph
creation_date: 2014-05-02T15:30:18Z

[Term]
id: GO:1902958
name: positive regulation of mitochondrial electron transport, NADH to ubiquinone
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitochondrial electron transport, NADH to ubiquinone." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:23530063]
synonym: "activation of complex I (NADH to ubiquinone)" RELATED [GOC:TermGenie]
synonym: "activation of mitochondrial electron transport, NADH to ubiquinone" NARROW [GOC:TermGenie]
synonym: "activation of oxidative phosphorylation, NADH to ubiquinone" NARROW [GOC:TermGenie]
synonym: "positive regulation of complex I (NADH to ubiquinone)" RELATED [GOC:TermGenie]
synonym: "positive regulation of oxidative phosphorylation, NADH to ubiquinone" EXACT [GOC:TermGenie]
synonym: "up regulation of complex I (NADH to ubiquinone)" RELATED [GOC:TermGenie]
synonym: "up regulation of mitochondrial electron transport, NADH to ubiquinone" EXACT [GOC:TermGenie]
synonym: "up regulation of oxidative phosphorylation, NADH to ubiquinone" EXACT [GOC:TermGenie]
synonym: "up-regulation of complex I (NADH to ubiquinone)" RELATED [GOC:TermGenie]
synonym: "up-regulation of mitochondrial electron transport, NADH to ubiquinone" EXACT [GOC:TermGenie]
synonym: "up-regulation of oxidative phosphorylation, NADH to ubiquinone" EXACT [GOC:TermGenie]
synonym: "upregulation of complex I (NADH to ubiquinone)" RELATED [GOC:TermGenie]
synonym: "upregulation of mitochondrial electron transport, NADH to ubiquinone" EXACT [GOC:TermGenie]
synonym: "upregulation of oxidative phosphorylation, NADH to ubiquinone" EXACT [GOC:TermGenie]
is_a: GO:1901857 ! positive regulation of cellular respiration
is_a: GO:1902956 ! regulation of mitochondrial electron transport, NADH to ubiquinone
is_a: GO:1903862 ! positive regulation of oxidative phosphorylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006120 ! mitochondrial electron transport, NADH to ubiquinone
relationship: positively_regulates GO:0006120 ! mitochondrial electron transport, NADH to ubiquinone
created_by: dph
creation_date: 2014-05-02T15:30:24Z

[Term]
id: GO:1902959
name: regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process." [GO_REF:0000059, GOC:sjp, GOC:TermGenie, PMID:24577224]
synonym: "regulation of aspartate protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of aspartate protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of aspartate protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of aspartate protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "regulation of aspartate protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of aspartate protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "regulation of aspartic endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of aspartic endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of aspartic protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of aspartic protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of aspartic protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of aspartic protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "regulation of aspartic protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of aspartic protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "regulation of aspartic-type endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of aspartic-type endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of aspartyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of aspartyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of aspartyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of aspartyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "regulation of aspartyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of aspartyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of carboxyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of carboxyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of carboxyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of carboxyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "regulation of carboxyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of carboxyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
is_a: GO:0052548 ! regulation of endopeptidase activity
is_a: GO:1902991 ! regulation of amyloid precursor protein catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1902944 ! aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
relationship: regulates GO:1902944 ! aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
created_by: sjp
creation_date: 2014-05-06T09:07:04Z

[Term]
id: GO:1902960
name: negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process." [GO_REF:0000059, GOC:sjp, GOC:TermGenie, PMID:24577224]
synonym: "down regulation of aspartate protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartate protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartate protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartate protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartate protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartate protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartic endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartic endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartic protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartic protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartic protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartic protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartic protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartic protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartic-type endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartic-type endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of aspartyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of carboxyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of carboxyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of carboxyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of carboxyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "down regulation of carboxyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of carboxyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartate protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartate protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartate protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartate protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartate protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartate protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartic endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartic endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartic protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartic protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartic protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartic protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartic protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartic protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartic-type endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartic-type endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of carboxyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of carboxyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of carboxyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of carboxyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of carboxyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of carboxyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartate protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartate protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartate protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartate protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartate protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartate protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartic endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartic endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartic protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartic protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartic protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartic protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartic protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartic protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartic-type endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartic-type endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of carboxyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of carboxyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of carboxyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of carboxyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of carboxyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of carboxyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of aspartate protease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartate protease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartate protease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartate protease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartate protease activity involved in APP catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartate protease activity involved in APP catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartic endopeptidase activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartic endopeptidase activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartic endopeptidase activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartic endopeptidase activity involved in APP catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartic endopeptidase activity involved in APP catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartic protease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartic protease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartic protease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartic protease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartic protease activity involved in APP catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartic protease activity involved in APP catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartic-type endopeptidase activity involved in APP catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartic-type endopeptidase activity involved in APP catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartyl protease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartyl protease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartyl protease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartyl protease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartyl protease activity involved in APP catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of aspartyl protease activity involved in APP catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of carboxyl protease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie]
synonym: "inhibition of carboxyl protease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of carboxyl protease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of carboxyl protease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie]
synonym: "inhibition of carboxyl protease activity involved in APP catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of carboxyl protease activity involved in APP catabolism" NARROW [GOC:TermGenie]
synonym: "negative regulation of aspartate protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartate protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartate protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartate protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartate protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartate protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartic endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartic endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartic protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartic protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartic protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartic protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartic protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartic protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartic-type endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartic-type endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of aspartyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of carboxyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of carboxyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of carboxyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of carboxyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "negative regulation of carboxyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of carboxyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
is_a: GO:0010951 ! negative regulation of endopeptidase activity
is_a: GO:1902959 ! regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
is_a: GO:1902992 ! negative regulation of amyloid precursor protein catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1902944 ! aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
relationship: negatively_regulates GO:1902944 ! aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
created_by: sjp
creation_date: 2014-05-06T09:07:11Z

[Term]
id: GO:1902961
name: positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process." [GO_REF:0000059, GOC:sjp, GOC:TermGenie, PMID:24577224]
synonym: "activation of aspartate protease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie]
synonym: "activation of aspartate protease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of aspartate protease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie]
synonym: "activation of aspartate protease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie]
synonym: "activation of aspartate protease activity involved in APP catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of aspartate protease activity involved in APP catabolism" NARROW [GOC:TermGenie]
synonym: "activation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie]
synonym: "activation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie]
synonym: "activation of aspartic endopeptidase activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie]
synonym: "activation of aspartic endopeptidase activity involved in APP catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of aspartic endopeptidase activity involved in APP catabolism" NARROW [GOC:TermGenie]
synonym: "activation of aspartic protease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie]
synonym: "activation of aspartic protease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of aspartic protease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie]
synonym: "activation of aspartic protease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie]
synonym: "activation of aspartic protease activity involved in APP catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of aspartic protease activity involved in APP catabolism" NARROW [GOC:TermGenie]
synonym: "activation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie]
synonym: "activation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie]
synonym: "activation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie]
synonym: "activation of aspartic-type endopeptidase activity involved in APP catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of aspartic-type endopeptidase activity involved in APP catabolism" NARROW [GOC:TermGenie]
synonym: "activation of aspartyl protease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie]
synonym: "activation of aspartyl protease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of aspartyl protease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie]
synonym: "activation of aspartyl protease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie]
synonym: "activation of aspartyl protease activity involved in APP catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of aspartyl protease activity involved in APP catabolism" NARROW [GOC:TermGenie]
synonym: "activation of carboxyl protease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie]
synonym: "activation of carboxyl protease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of carboxyl protease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie]
synonym: "activation of carboxyl protease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie]
synonym: "activation of carboxyl protease activity involved in APP catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of carboxyl protease activity involved in APP catabolism" NARROW [GOC:TermGenie]
synonym: "positive regulation of aspartate protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartate protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartate protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartate protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartate protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartate protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartic endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartic endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartic protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartic protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartic protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartic protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartic protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartic protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartic-type endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartic-type endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of aspartyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of carboxyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of carboxyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of carboxyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of carboxyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of carboxyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of carboxyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartate protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartate protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartate protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartate protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartate protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartate protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartic endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartic endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartic protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartic protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartic protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartic protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartic protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartic protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartic-type endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartic-type endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of aspartyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of carboxyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of carboxyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of carboxyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of carboxyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of carboxyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of carboxyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartate protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartate protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartate protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartate protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartate protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartate protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartic endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartic endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartic protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartic protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartic protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartic protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartic protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartic protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartic-type endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartic-type endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of carboxyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of carboxyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of carboxyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of carboxyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of carboxyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of carboxyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartate protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartate protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartate protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartate protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartate protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartate protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartic endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartic endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartic protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartic protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartic protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartic protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartic protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartic protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartic-type endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartic-type endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of carboxyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of carboxyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of carboxyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of carboxyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of carboxyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of carboxyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie]
is_a: GO:0010950 ! positive regulation of endopeptidase activity
is_a: GO:1902959 ! regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
is_a: GO:1902993 ! positive regulation of amyloid precursor protein catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1902944 ! aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
relationship: positively_regulates GO:1902944 ! aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
created_by: sjp
creation_date: 2014-05-06T09:07:17Z

[Term]
id: GO:1902962
name: regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of metalloendopeptidase activity involved in amyloid precursor protein catabolic process." [GO_REF:0000059, GOC:sjp, GOC:TermGenie, PMID:18362153]
synonym: "regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of metalloendopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "regulation of metalloendopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of metalloendopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of metalloendoprotease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of metalloendoprotease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "regulation of metalloendoprotease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of metalloendoprotease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "regulation of metalloendoproteinase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of metalloendoproteinase activity involved in APP catabolism" EXACT [GOC:TermGenie]
is_a: GO:1902991 ! regulation of amyloid precursor protein catabolic process
is_a: GO:1904683 ! regulation of metalloendopeptidase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1902945 ! metalloendopeptidase activity involved in amyloid precursor protein catabolic process
relationship: regulates GO:1902945 ! metalloendopeptidase activity involved in amyloid precursor protein catabolic process
created_by: sjp
creation_date: 2014-05-06T09:11:55Z

[Term]
id: GO:1902963
name: negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of metalloendopeptidase activity involved in amyloid precursor protein catabolic process." [GO_REF:0000059, GOC:sjp, GOC:TermGenie, PMID:18362153]
synonym: "down regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of metalloendopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "down regulation of metalloendopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of metalloendopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of metalloendoprotease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of metalloendoprotease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "down regulation of metalloendoprotease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of metalloendoprotease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "down regulation of metalloendoproteinase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of metalloendoproteinase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of metalloendopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of metalloendopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of metalloendopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of metalloendoprotease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of metalloendoprotease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of metalloendoprotease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of metalloendoprotease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of metalloendoproteinase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of metalloendoproteinase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of metalloendopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of metalloendopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of metalloendopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of metalloendoprotease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of metalloendoprotease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of metalloendoprotease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of metalloendoprotease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of metalloendoprotease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of metalloendoproteinase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of metalloendoproteinase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of metalloendoproteinase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of metalloendopeptidase activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie]
synonym: "inhibition of metalloendopeptidase activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of metalloendopeptidase activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of metalloendopeptidase activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie]
synonym: "inhibition of metalloendopeptidase activity involved in APP catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of metalloendopeptidase activity involved in APP catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of metalloendoprotease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie]
synonym: "inhibition of metalloendoprotease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of metalloendoprotease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of metalloendoprotease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie]
synonym: "inhibition of metalloendoprotease activity involved in APP catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of metalloendoprotease activity involved in APP catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of metalloendoproteinase activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie]
synonym: "inhibition of metalloendoproteinase activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of metalloendoproteinase activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of metalloendoproteinase activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie]
synonym: "inhibition of metalloendoproteinase activity involved in APP catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of metalloendoproteinase activity involved in APP catabolism" NARROW [GOC:TermGenie]
synonym: "negative regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of metalloendopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "negative regulation of metalloendopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of metalloendopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of metalloendoprotease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of metalloendoprotease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "negative regulation of metalloendoprotease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of metalloendoprotease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "negative regulation of metalloendoproteinase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of metalloendoproteinase activity involved in APP catabolism" EXACT [GOC:TermGenie]
is_a: GO:1902962 ! regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process
is_a: GO:1902992 ! negative regulation of amyloid precursor protein catabolic process
is_a: GO:1904684 ! negative regulation of metalloendopeptidase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1902945 ! metalloendopeptidase activity involved in amyloid precursor protein catabolic process
relationship: negatively_regulates GO:1902945 ! metalloendopeptidase activity involved in amyloid precursor protein catabolic process
created_by: sjp
creation_date: 2014-05-06T09:12:01Z

[Term]
id: GO:1902964
name: positive regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of metalloendopeptidase activity involved in amyloid precursor protein catabolic process." [GO_REF:0000059, GOC:sjp, GOC:TermGenie, PMID:18362153]
synonym: "activation of metalloendopeptidase activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie]
synonym: "activation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of metalloendopeptidase activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie]
synonym: "activation of metalloendopeptidase activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie]
synonym: "activation of metalloendopeptidase activity involved in APP catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of metalloendopeptidase activity involved in APP catabolism" NARROW [GOC:TermGenie]
synonym: "activation of metalloendoprotease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie]
synonym: "activation of metalloendoprotease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of metalloendoprotease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie]
synonym: "activation of metalloendoprotease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie]
synonym: "activation of metalloendoprotease activity involved in APP catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of metalloendoprotease activity involved in APP catabolism" NARROW [GOC:TermGenie]
synonym: "activation of metalloendoproteinase activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie]
synonym: "activation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of metalloendoproteinase activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie]
synonym: "activation of metalloendoproteinase activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie]
synonym: "activation of metalloendoproteinase activity involved in APP catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of metalloendoproteinase activity involved in APP catabolism" NARROW [GOC:TermGenie]
synonym: "positive regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of metalloendopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of metalloendopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of metalloendopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of metalloendoprotease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of metalloendoprotease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of metalloendoprotease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of metalloendoprotease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of metalloendoproteinase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of metalloendoproteinase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of metalloendopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of metalloendopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of metalloendopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of metalloendoprotease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of metalloendoprotease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of metalloendoprotease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of metalloendoprotease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of metalloendoproteinase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of metalloendoproteinase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of metalloendopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of metalloendopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of metalloendopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of metalloendoprotease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of metalloendoprotease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of metalloendoprotease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of metalloendoprotease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of metalloendoproteinase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of metalloendoproteinase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of metalloendopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of metalloendopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of metalloendopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of metalloendoprotease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of metalloendoprotease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of metalloendoprotease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of metalloendoprotease activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of metalloendoprotease activity involved in APP catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of metalloendoproteinase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of metalloendoproteinase activity involved in APP catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of metalloendoproteinase activity involved in APP catabolism" EXACT [GOC:TermGenie]
is_a: GO:1902962 ! regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process
is_a: GO:1902993 ! positive regulation of amyloid precursor protein catabolic process
is_a: GO:1904685 ! positive regulation of metalloendopeptidase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1902945 ! metalloendopeptidase activity involved in amyloid precursor protein catabolic process
relationship: positively_regulates GO:1902945 ! metalloendopeptidase activity involved in amyloid precursor protein catabolic process
created_by: sjp
creation_date: 2014-05-06T09:12:11Z

[Term]
id: GO:1902965
name: regulation of protein localization to early endosome
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to early endosome." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:22621900]
synonym: "regulation of protein localisation in early endosome" EXACT [GOC:TermGenie]
synonym: "regulation of protein localisation to early endosome" EXACT [GOC:TermGenie]
synonym: "regulation of protein localization in early endosome" EXACT [GOC:TermGenie]
is_a: GO:1903827 ! regulation of cellular protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1902946 ! protein localization to early endosome
relationship: regulates GO:1902946 ! protein localization to early endosome
created_by: sjp
creation_date: 2014-05-06T09:28:24Z

[Term]
id: GO:1902966
name: positive regulation of protein localization to early endosome
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to early endosome." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:22621900]
synonym: "activation of protein localisation in early endosome" NARROW [GOC:TermGenie]
synonym: "activation of protein localisation to early endosome" NARROW [GOC:TermGenie]
synonym: "activation of protein localization in early endosome" NARROW [GOC:TermGenie]
synonym: "activation of protein localization to early endosome" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein localisation in early endosome" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localisation to early endosome" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localization in early endosome" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation in early endosome" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation to early endosome" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization in early endosome" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to early endosome" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation in early endosome" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation to early endosome" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization in early endosome" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to early endosome" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation in early endosome" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation to early endosome" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization in early endosome" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to early endosome" EXACT [GOC:TermGenie]
is_a: GO:1902965 ! regulation of protein localization to early endosome
is_a: GO:1903829 ! positive regulation of cellular protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1902946 ! protein localization to early endosome
relationship: positively_regulates GO:1902946 ! protein localization to early endosome
created_by: sjp
creation_date: 2014-05-06T09:28:30Z

[Term]
id: GO:1902967
name: protein localization to mitotic spindle midzone
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a mitotic spindle midzone." [GO_REF:0000087, GOC:TermGenie, PMID:16824200]
synonym: "protein localisation in mitotic spindle midzone" EXACT [GOC:TermGenie]
synonym: "protein localisation to mitotic spindle midzone" EXACT [GOC:TermGenie]
synonym: "protein localization in mitotic spindle midzone" EXACT [GOC:TermGenie]
is_a: GO:1902480 ! protein localization to mitotic spindle
created_by: mah
creation_date: 2014-05-06T14:40:01Z

[Term]
id: GO:1902969
name: mitotic DNA replication
namespace: biological_process
def: "Any nuclear DNA replication that is involved in a mitotic cell cycle." [GO_REF:0000060, GOC:TermGenie]
synonym: "DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "mitotic cell cycle DNA replication" EXACT []
synonym: "mitotic nuclear cell cycle DNA replication" EXACT []
synonym: "nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED []
is_a: GO:0033260 ! nuclear DNA replication
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0033260 ! nuclear DNA replication
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0000278 ! mitotic cell cycle
created_by: jl
creation_date: 2014-05-06T15:03:03Z

[Term]
id: GO:1902970
name: premeiotic DNA replication DNA duplex unwinding
namespace: biological_process
def: "Any DNA duplex unwinding involved in meiotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie]
synonym: "DNA duplex unwinding involved in meiotic cell cycle DNA replication" EXACT []
synonym: "DNA duplex unwinding involved in meiotic DNA replication" EXACT []
is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle
is_a: GO:1902320 ! nuclear DNA replication DNA duplex unwinding
intersection_of: GO:1902320 ! nuclear DNA replication DNA duplex unwinding
intersection_of: part_of GO:0006279 ! premeiotic DNA replication
relationship: part_of GO:0006279 ! premeiotic DNA replication
relationship: part_of GO:0051321 ! meiotic cell cycle
created_by: jl
creation_date: 2014-05-06T15:20:41Z

[Term]
id: GO:1902971
name: mitotic DNA replication DNA duplex unwinding
namespace: biological_process
def: "Any DNA duplex unwinding involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie]
synonym: "DNA duplex unwinding involved in mitotic cell cycle DNA replication" EXACT []
synonym: "DNA duplex unwinding involved in mitotic DNA replication" EXACT []
is_a: GO:1902320 ! nuclear DNA replication DNA duplex unwinding
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:1902320 ! nuclear DNA replication DNA duplex unwinding
intersection_of: part_of GO:1902969 ! mitotic DNA replication
relationship: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:1902969 ! mitotic DNA replication
created_by: jl
creation_date: 2014-05-06T15:20:47Z

[Term]
id: GO:1902972
name: premeiotic DNA replication DNA ligation
namespace: biological_process
def: "Any DNA ligation involved in meiotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie]
synonym: "DNA ligation involved in meiotic cell cycle DNA replication" RELATED []
synonym: "DNA ligation involved in meiotic DNA replication" EXACT []
is_a: GO:1902333 ! nuclear DNA replication DNA ligation
is_a: GO:1903046 ! meiotic cell cycle process
intersection_of: GO:1902333 ! nuclear DNA replication DNA ligation
intersection_of: part_of GO:0006279 ! premeiotic DNA replication
relationship: part_of GO:0006279 ! premeiotic DNA replication
relationship: part_of GO:0051321 ! meiotic cell cycle
created_by: jl
creation_date: 2014-05-06T15:20:53Z

[Term]
id: GO:1902973
name: mitotic DNA replication DNA ligation
namespace: biological_process
def: "Any DNA ligation involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie]
synonym: "DNA ligation involved in mitotic cell cycle DNA replication" EXACT []
synonym: "DNA ligation involved in mitotic DNA replication" EXACT []
is_a: GO:1902333 ! nuclear DNA replication DNA ligation
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:1902333 ! nuclear DNA replication DNA ligation
intersection_of: part_of GO:1902969 ! mitotic DNA replication
relationship: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:1902969 ! mitotic DNA replication
created_by: jl
creation_date: 2014-05-06T15:20:59Z

[Term]
id: GO:1902974
name: meiotic DNA replication initiation
namespace: biological_process
def: "Any DNA replication initiation involved in meiotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie]
synonym: "DNA replication initiation involved in meiotic cell cycle DNA replication" EXACT []
synonym: "DNA replication initiation involved in meiotic DNA replication" EXACT []
is_a: GO:1902315 ! nuclear cell cycle DNA replication initiation
is_a: GO:1903046 ! meiotic cell cycle process
intersection_of: GO:1902315 ! nuclear cell cycle DNA replication initiation
intersection_of: part_of GO:0051321 ! meiotic cell cycle
relationship: part_of GO:0051321 ! meiotic cell cycle
created_by: jl
creation_date: 2014-05-06T15:21:06Z

[Term]
id: GO:1902975
name: mitotic DNA replication initiation
namespace: biological_process
def: "Any DNA replication initiation involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie]
synonym: "DNA replication initiation involved in mitotic cell cycle DNA replication" EXACT []
is_a: GO:1902315 ! nuclear cell cycle DNA replication initiation
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:1902315 ! nuclear cell cycle DNA replication initiation
intersection_of: part_of GO:1902969 ! mitotic DNA replication
relationship: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:1902969 ! mitotic DNA replication
created_by: jl
creation_date: 2014-05-06T15:21:11Z

[Term]
id: GO:1902976
name: premeiotic DNA replication preinitiation complex assembly
namespace: biological_process
def: "Any DNA replication preinitiation complex assembly that is involved in meiotic cell cycle." [GO_REF:0000060, GOC:TermGenie]
synonym: "DNA replication preinitiation complex formation involved in meiotic cell cycle" EXACT [GOC:TermGenie]
synonym: "pre-IC complex assembly involved in meiotic cell cycle" EXACT [GOC:TermGenie]
is_a: GO:0071163 ! DNA replication preinitiation complex assembly
is_a: GO:1903046 ! meiotic cell cycle process
intersection_of: GO:0071163 ! DNA replication preinitiation complex assembly
intersection_of: part_of GO:0006279 ! premeiotic DNA replication
relationship: part_of GO:0006279 ! premeiotic DNA replication
relationship: part_of GO:0051321 ! meiotic cell cycle
created_by: jl
creation_date: 2014-05-06T19:19:31Z

[Term]
id: GO:1902977
name: mitotic DNA replication preinitiation complex assembly
namespace: biological_process
def: "Any DNA replication preinitiation complex assembly that is involved in mitotic cell cycle." [GO_REF:0000060, GOC:TermGenie]
synonym: "DNA replication preinitiation complex formation involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "pre-IC complex assembly involved in mitotic cell cycle" EXACT [GOC:TermGenie]
is_a: GO:0071163 ! DNA replication preinitiation complex assembly
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0071163 ! DNA replication preinitiation complex assembly
intersection_of: part_of GO:1902969 ! mitotic DNA replication
relationship: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:1902969 ! mitotic DNA replication
created_by: jl
creation_date: 2014-05-06T19:19:37Z

[Term]
id: GO:1902978
name: premeiotic DNA replication termination
namespace: biological_process
def: "Any DNA replication termination involved in meiotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie]
synonym: "DNA replication termination involved in meiotic cell cycle DNA replication" EXACT []
synonym: "DNA replication termination involved in meiotic DNA replication" EXACT []
is_a: GO:1902317 ! nuclear DNA replication termination
is_a: GO:1903046 ! meiotic cell cycle process
intersection_of: GO:1902317 ! nuclear DNA replication termination
intersection_of: part_of GO:0006279 ! premeiotic DNA replication
relationship: part_of GO:0006279 ! premeiotic DNA replication
relationship: part_of GO:0051321 ! meiotic cell cycle
created_by: jl
creation_date: 2014-05-06T19:19:43Z

[Term]
id: GO:1902979
name: mitotic DNA replication termination
namespace: biological_process
def: "Any DNA replication termination involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie]
synonym: "DNA replication termination involved in mitotic cell cycle DNA replication" EXACT []
is_a: GO:1902317 ! nuclear DNA replication termination
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:1902317 ! nuclear DNA replication termination
intersection_of: part_of GO:1902969 ! mitotic DNA replication
relationship: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:1902969 ! mitotic DNA replication
created_by: jl
creation_date: 2014-05-06T19:19:49Z

[Term]
id: GO:1902980
name: synthesis of RNA primer involved in premeiotic DNA replication
namespace: biological_process
def: "Any synthesis of RNA primer involved in meiotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie]
synonym: "synthesis of RNA primer involved in meiotic cell cycle DNA replication" EXACT []
is_a: GO:1902318 ! synthesis of RNA primer involved in nuclear cell cycle DNA replication
is_a: GO:1903046 ! meiotic cell cycle process
intersection_of: GO:1902318 ! synthesis of RNA primer involved in nuclear cell cycle DNA replication
intersection_of: part_of GO:0006279 ! premeiotic DNA replication
relationship: part_of GO:0006279 ! premeiotic DNA replication
relationship: part_of GO:0051321 ! meiotic cell cycle
created_by: jl
creation_date: 2014-05-06T19:19:54Z

[Term]
id: GO:1902981
name: synthesis of RNA primer involved in mitotic DNA replication
namespace: biological_process
alt_id: GO:1903458
def: "Any synthesis of RNA primer involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie]
synonym: "synthesis of RNA primer involved in mitotic cell cycle DNA replication" EXACT []
is_a: GO:1902318 ! synthesis of RNA primer involved in nuclear cell cycle DNA replication
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0006269 ! DNA replication, synthesis of RNA primer
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:1902969 ! mitotic DNA replication
created_by: jl
creation_date: 2014-05-06T19:20:00Z

[Term]
id: GO:1902982
name: DNA strand elongation involved in premeiotic DNA replication
namespace: biological_process
def: "Any DNA strand elongation involved in meiotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie]
synonym: "DNA strand elongation involved in meiotic cell cycle DNA replication" EXACT []
is_a: GO:1902319 ! DNA strand elongation involved in nuclear cell cycle DNA replication
is_a: GO:1903046 ! meiotic cell cycle process
intersection_of: GO:1902319 ! DNA strand elongation involved in nuclear cell cycle DNA replication
intersection_of: part_of GO:0006279 ! premeiotic DNA replication
relationship: part_of GO:0006279 ! premeiotic DNA replication
relationship: part_of GO:0051321 ! meiotic cell cycle
created_by: jl
creation_date: 2014-05-06T20:33:15Z

[Term]
id: GO:1902983
name: DNA strand elongation involved in mitotic DNA replication
namespace: biological_process
def: "Any DNA strand elongation involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie]
synonym: "DNA strand elongation involved in mitotic cell cycle DNA replication" EXACT []
is_a: GO:1902319 ! DNA strand elongation involved in nuclear cell cycle DNA replication
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:1902319 ! DNA strand elongation involved in nuclear cell cycle DNA replication
intersection_of: part_of GO:1902969 ! mitotic DNA replication
relationship: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:1902969 ! mitotic DNA replication
created_by: jl
creation_date: 2014-05-06T20:33:22Z

[Term]
id: GO:1902984
name: pre-replicative complex assembly involved in premeiotic DNA replication
namespace: biological_process
def: "Any pre-replicative complex assembly involved in meiotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie]
synonym: "nuclear pre-replicative complex assembly involved in meiotic cell cycle" EXACT [GOC:TermGenie]
synonym: "pre-RC complex assembly involved in meiosis" BROAD [GOC:TermGenie]
synonym: "pre-replicative complex assembly involved in meiosis" BROAD [GOC:TermGenie]
synonym: "pre-replicative complex assembly involved in meiotic cell cycle DNA replication" EXACT []
synonym: "pre-replicative complex formation involved in meiosis" BROAD [GOC:TermGenie]
is_a: GO:0006267 ! pre-replicative complex assembly involved in nuclear cell cycle DNA replication
is_a: GO:1903046 ! meiotic cell cycle process
intersection_of: GO:0006267 ! pre-replicative complex assembly involved in nuclear cell cycle DNA replication
intersection_of: part_of GO:0006279 ! premeiotic DNA replication
relationship: part_of GO:0006279 ! premeiotic DNA replication
relationship: part_of GO:0051321 ! meiotic cell cycle
created_by: jl
creation_date: 2014-05-06T20:33:28Z

[Term]
id: GO:1902985
name: mitotic pre-replicative complex assembly
namespace: biological_process
def: "Any pre-replicative complex assembly involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie]
synonym: "nuclear pre-replicative complex assembly involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "pre-replicative complex assembly involved in mitotic cell cycle DNA replication" EXACT []
is_a: GO:0006267 ! pre-replicative complex assembly involved in nuclear cell cycle DNA replication
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0006267 ! pre-replicative complex assembly involved in nuclear cell cycle DNA replication
intersection_of: part_of GO:1902969 ! mitotic DNA replication
relationship: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:1902969 ! mitotic DNA replication
created_by: jl
creation_date: 2014-05-06T20:33:34Z

[Term]
id: GO:1902986
name: regulation of lysine biosynthetic process via aminoadipic acid
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lysine biosynthetic process via aminoadipic acid." [GO_REF:0000058, GOC:TermGenie, PMID:8590464]
synonym: "regulation of lysine anabolism via aminoadipic acid" EXACT [GOC:TermGenie]
synonym: "regulation of lysine biosynthesis, aminoadipic acid pathway" EXACT [GOC:TermGenie]
synonym: "regulation of lysine biosynthesis, aminoadipic pathway" EXACT [GOC:TermGenie]
synonym: "regulation of lysine biosynthetic process, aminoadipic acid pathway" EXACT [GOC:TermGenie]
synonym: "regulation of lysine biosynthetic process, aminoadipic pathway" EXACT [GOC:TermGenie]
synonym: "regulation of lysine formation via aminoadipic acid" EXACT [GOC:TermGenie]
synonym: "regulation of lysine synthesis via aminoadipic acid" EXACT [GOC:TermGenie]
is_a: GO:2000282 ! regulation of cellular amino acid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019878 ! lysine biosynthetic process via aminoadipic acid
relationship: regulates GO:0019878 ! lysine biosynthetic process via aminoadipic acid
created_by: al
creation_date: 2014-05-07T08:07:08Z

[Term]
id: GO:1902987
name: negative regulation of lysine biosynthetic process via aminoadipic acid
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lysine biosynthetic process via aminoadipic acid." [GO_REF:0000058, GOC:TermGenie, PMID:8590464]
synonym: "down regulation of lysine anabolism via aminoadipic acid" EXACT [GOC:TermGenie]
synonym: "down regulation of lysine biosynthesis, aminoadipic acid pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of lysine biosynthesis, aminoadipic pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of lysine biosynthetic process via aminoadipic acid" EXACT [GOC:TermGenie]
synonym: "down regulation of lysine biosynthetic process, aminoadipic acid pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of lysine biosynthetic process, aminoadipic pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of lysine formation via aminoadipic acid" EXACT [GOC:TermGenie]
synonym: "down regulation of lysine synthesis via aminoadipic acid" EXACT [GOC:TermGenie]
synonym: "down-regulation of lysine anabolism via aminoadipic acid" EXACT [GOC:TermGenie]
synonym: "down-regulation of lysine biosynthesis, aminoadipic acid pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of lysine biosynthesis, aminoadipic pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of lysine biosynthetic process via aminoadipic acid" EXACT [GOC:TermGenie]
synonym: "down-regulation of lysine biosynthetic process, aminoadipic acid pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of lysine biosynthetic process, aminoadipic pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of lysine formation via aminoadipic acid" EXACT [GOC:TermGenie]
synonym: "down-regulation of lysine synthesis via aminoadipic acid" EXACT [GOC:TermGenie]
synonym: "downregulation of lysine anabolism via aminoadipic acid" EXACT [GOC:TermGenie]
synonym: "downregulation of lysine biosynthesis, aminoadipic acid pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of lysine biosynthesis, aminoadipic pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of lysine biosynthetic process via aminoadipic acid" EXACT [GOC:TermGenie]
synonym: "downregulation of lysine biosynthetic process, aminoadipic acid pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of lysine biosynthetic process, aminoadipic pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of lysine formation via aminoadipic acid" EXACT [GOC:TermGenie]
synonym: "downregulation of lysine synthesis via aminoadipic acid" EXACT [GOC:TermGenie]
synonym: "inhibition of lysine anabolism via aminoadipic acid" NARROW [GOC:TermGenie]
synonym: "inhibition of lysine biosynthesis, aminoadipic acid pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of lysine biosynthesis, aminoadipic pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of lysine biosynthetic process via aminoadipic acid" NARROW [GOC:TermGenie]
synonym: "inhibition of lysine biosynthetic process, aminoadipic acid pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of lysine biosynthetic process, aminoadipic pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of lysine formation via aminoadipic acid" NARROW [GOC:TermGenie]
synonym: "inhibition of lysine synthesis via aminoadipic acid" NARROW [GOC:TermGenie]
synonym: "negative regulation of lysine anabolism via aminoadipic acid" EXACT [GOC:TermGenie]
synonym: "negative regulation of lysine biosynthesis, aminoadipic acid pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of lysine biosynthesis, aminoadipic pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of lysine biosynthetic process, aminoadipic acid pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of lysine biosynthetic process, aminoadipic pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of lysine formation via aminoadipic acid" EXACT [GOC:TermGenie]
synonym: "negative regulation of lysine synthesis via aminoadipic acid" EXACT [GOC:TermGenie]
is_a: GO:1902986 ! regulation of lysine biosynthetic process via aminoadipic acid
is_a: GO:2000283 ! negative regulation of cellular amino acid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019878 ! lysine biosynthetic process via aminoadipic acid
relationship: negatively_regulates GO:0019878 ! lysine biosynthetic process via aminoadipic acid
created_by: al
creation_date: 2014-05-07T08:07:15Z

[Term]
id: GO:1902988
name: neurofibrillary tangle assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a neurofibrillary tangle." [GO_REF:0000079, GOC:sjp, GOC:TermGenie, PMID:15897157, PMID:22986780, PMID:24154541]
comment: Neurofibrillary tangles have been found in aging population; their formation is increased in Alzheimer's disease patients (and in other neurological diseases) compared to normal controls (see PMID:848276 and PMID:8584267).
synonym: "flame-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie]
synonym: "flame-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie]
synonym: "neurofibrillary tangle formation" EXACT [GOC:TermGenie]
synonym: "star-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie]
synonym: "star-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie]
is_a: GO:0070841 ! inclusion body assembly
created_by: sjp
creation_date: 2014-05-08T09:19:51Z

[Term]
id: GO:1902989
name: meiotic telomere maintenance via semi-conservative replication
namespace: biological_process
def: "Any telomere maintenance via semi-conservative replication that is involved in meiotic cell cycle." [GO_REF:0000060, GOC:TermGenie]
synonym: "equal telomere replication involved in meiotic cell cycle" RELATED [GOC:TermGenie]
synonym: "telomeric fork progression involved in meiotic cell cycle" NARROW [GOC:TermGenie]
synonym: "telomeric replication fork progression involved in meiotic cell cycle" NARROW [GOC:TermGenie]
is_a: GO:0032201 ! telomere maintenance via semi-conservative replication
is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle
intersection_of: GO:0032201 ! telomere maintenance via semi-conservative replication
intersection_of: part_of GO:0051321 ! meiotic cell cycle
relationship: part_of GO:0051321 ! meiotic cell cycle
created_by: jl
creation_date: 2014-05-08T11:13:43Z

[Term]
id: GO:1902990
name: mitotic telomere maintenance via semi-conservative replication
namespace: biological_process
def: "Any telomere maintenance via semi-conservative replication that is involved in mitotic cell cycle." [GO_REF:0000060, GOC:TermGenie]
synonym: "equal telomere replication involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "telomeric fork progression involved in mitotic cell cycle" NARROW [GOC:TermGenie]
synonym: "telomeric replication fork progression involved in mitotic cell cycle" NARROW [GOC:TermGenie]
is_a: GO:0032201 ! telomere maintenance via semi-conservative replication
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0032201 ! telomere maintenance via semi-conservative replication
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0000278 ! mitotic cell cycle
created_by: jl
creation_date: 2014-05-08T11:13:49Z

[Term]
id: GO:1902991
name: regulation of amyloid precursor protein catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of amyloid precursor protein catabolic process." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:24499793]
comment: An example of this is human FKBP1A/12 (UniProt symbol P62942) in PMID:24499793 (inferred from direct assay).
synonym: "regulation of amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "regulation of APP catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of APP catabolism" EXACT [GOC:TermGenie]
is_a: GO:0051246 ! regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042987 ! amyloid precursor protein catabolic process
relationship: regulates GO:0042987 ! amyloid precursor protein catabolic process
created_by: rl
creation_date: 2014-05-08T14:21:04Z

[Term]
id: GO:1902992
name: negative regulation of amyloid precursor protein catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of amyloid precursor protein catabolic process." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:24499793]
synonym: "down regulation of amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "down regulation of APP catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of APP catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of APP catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of APP catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of APP catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of APP catabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of amyloid precursor protein breakdown" NARROW [GOC:TermGenie]
synonym: "inhibition of amyloid precursor protein catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of amyloid precursor protein catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of amyloid precursor protein degradation" NARROW [GOC:TermGenie]
synonym: "inhibition of APP catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of APP catabolism" NARROW [GOC:TermGenie]
synonym: "negative regulation of amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "negative regulation of APP catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of APP catabolism" EXACT [GOC:TermGenie]
is_a: GO:0051248 ! negative regulation of protein metabolic process
is_a: GO:1902991 ! regulation of amyloid precursor protein catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042987 ! amyloid precursor protein catabolic process
relationship: negatively_regulates GO:0042987 ! amyloid precursor protein catabolic process
created_by: rl
creation_date: 2014-05-08T14:21:10Z

[Term]
id: GO:1902993
name: positive regulation of amyloid precursor protein catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of amyloid precursor protein catabolic process." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:24499793]
synonym: "activation of amyloid precursor protein breakdown" NARROW [GOC:TermGenie]
synonym: "activation of amyloid precursor protein catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of amyloid precursor protein catabolism" NARROW [GOC:TermGenie]
synonym: "activation of amyloid precursor protein degradation" NARROW [GOC:TermGenie]
synonym: "activation of APP catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of APP catabolism" NARROW [GOC:TermGenie]
synonym: "positive regulation of amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of APP catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of APP catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of APP catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of APP catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of APP catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of APP catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of amyloid precursor protein breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of amyloid precursor protein catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of amyloid precursor protein catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of amyloid precursor protein degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of APP catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of APP catabolism" EXACT [GOC:TermGenie]
is_a: GO:0051247 ! positive regulation of protein metabolic process
is_a: GO:1902991 ! regulation of amyloid precursor protein catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042987 ! amyloid precursor protein catabolic process
relationship: positively_regulates GO:0042987 ! amyloid precursor protein catabolic process
created_by: rl
creation_date: 2014-05-08T14:21:16Z

[Term]
id: GO:1902994
name: regulation of phospholipid efflux
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phospholipid efflux." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:12042316]
synonym: "regulation of phospholipid export" EXACT [GOC:TermGenie]
is_a: GO:2001138 ! regulation of phospholipid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0033700 ! phospholipid efflux
relationship: regulates GO:0033700 ! phospholipid efflux
created_by: sjp
creation_date: 2014-05-08T14:55:16Z

[Term]
id: GO:1902995
name: positive regulation of phospholipid efflux
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phospholipid efflux." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:12042316]
synonym: "activation of phospholipid efflux" NARROW [GOC:TermGenie]
synonym: "activation of phospholipid export" NARROW [GOC:TermGenie]
synonym: "positive regulation of phospholipid export" EXACT [GOC:TermGenie]
synonym: "up regulation of phospholipid efflux" EXACT [GOC:TermGenie]
synonym: "up regulation of phospholipid export" EXACT [GOC:TermGenie]
synonym: "up-regulation of phospholipid efflux" EXACT [GOC:TermGenie]
synonym: "up-regulation of phospholipid export" EXACT [GOC:TermGenie]
synonym: "upregulation of phospholipid efflux" EXACT [GOC:TermGenie]
synonym: "upregulation of phospholipid export" EXACT [GOC:TermGenie]
is_a: GO:1902994 ! regulation of phospholipid efflux
is_a: GO:2001140 ! positive regulation of phospholipid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0033700 ! phospholipid efflux
relationship: positively_regulates GO:0033700 ! phospholipid efflux
created_by: sjp
creation_date: 2014-05-08T14:55:22Z

[Term]
id: GO:1902996
name: regulation of neurofibrillary tangle assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neurofibrillary tangle assembly." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:15897157]
synonym: "regulation of flame-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie]
synonym: "regulation of flame-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie]
synonym: "regulation of neurofibrillary tangle formation" EXACT [GOC:TermGenie]
synonym: "regulation of star-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie]
synonym: "regulation of star-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie]
is_a: GO:0090083 ! regulation of inclusion body assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1902988 ! neurofibrillary tangle assembly
relationship: regulates GO:1902988 ! neurofibrillary tangle assembly
created_by: sjp
creation_date: 2014-05-08T15:44:27Z

[Term]
id: GO:1902997
name: negative regulation of neurofibrillary tangle assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of neurofibrillary tangle assembly." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:15897157]
synonym: "down regulation of flame-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie]
synonym: "down regulation of flame-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie]
synonym: "down regulation of neurofibrillary tangle assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of neurofibrillary tangle formation" EXACT [GOC:TermGenie]
synonym: "down regulation of star-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie]
synonym: "down regulation of star-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie]
synonym: "down-regulation of flame-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie]
synonym: "down-regulation of flame-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie]
synonym: "down-regulation of neurofibrillary tangle assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of neurofibrillary tangle formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of star-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie]
synonym: "down-regulation of star-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie]
synonym: "downregulation of flame-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie]
synonym: "downregulation of flame-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie]
synonym: "downregulation of neurofibrillary tangle assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of neurofibrillary tangle formation" EXACT [GOC:TermGenie]
synonym: "downregulation of star-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie]
synonym: "downregulation of star-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie]
synonym: "inhibition of flame-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of flame-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie]
synonym: "inhibition of neurofibrillary tangle assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of neurofibrillary tangle formation" NARROW [GOC:TermGenie]
synonym: "inhibition of star-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of star-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of flame-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie]
synonym: "negative regulation of flame-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of neurofibrillary tangle formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of star-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie]
synonym: "negative regulation of star-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie]
is_a: GO:0090084 ! negative regulation of inclusion body assembly
is_a: GO:1902996 ! regulation of neurofibrillary tangle assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1902988 ! neurofibrillary tangle assembly
relationship: negatively_regulates GO:1902988 ! neurofibrillary tangle assembly
created_by: sjp
creation_date: 2014-05-08T15:44:33Z

[Term]
id: GO:1902998
name: positive regulation of neurofibrillary tangle assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neurofibrillary tangle assembly." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:15897157]
synonym: "activation of flame-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie]
synonym: "activation of flame-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie]
synonym: "activation of neurofibrillary tangle assembly" NARROW [GOC:TermGenie]
synonym: "activation of neurofibrillary tangle formation" NARROW [GOC:TermGenie]
synonym: "activation of star-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie]
synonym: "activation of star-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of flame-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie]
synonym: "positive regulation of flame-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of neurofibrillary tangle formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of star-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie]
synonym: "positive regulation of star-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie]
synonym: "up regulation of flame-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie]
synonym: "up regulation of flame-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie]
synonym: "up regulation of neurofibrillary tangle assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of neurofibrillary tangle formation" EXACT [GOC:TermGenie]
synonym: "up regulation of star-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie]
synonym: "up regulation of star-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie]
synonym: "up-regulation of flame-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie]
synonym: "up-regulation of flame-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie]
synonym: "up-regulation of neurofibrillary tangle assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of neurofibrillary tangle formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of star-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie]
synonym: "up-regulation of star-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie]
synonym: "upregulation of flame-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie]
synonym: "upregulation of flame-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie]
synonym: "upregulation of neurofibrillary tangle assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of neurofibrillary tangle formation" EXACT [GOC:TermGenie]
synonym: "upregulation of star-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie]
synonym: "upregulation of star-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie]
is_a: GO:0090261 ! positive regulation of inclusion body assembly
is_a: GO:1902996 ! regulation of neurofibrillary tangle assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1902988 ! neurofibrillary tangle assembly
relationship: positively_regulates GO:1902988 ! neurofibrillary tangle assembly
created_by: sjp
creation_date: 2014-05-08T15:44:45Z

[Term]
id: GO:1902999
name: negative regulation of phospholipid efflux
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of phospholipid efflux." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:12042316]
synonym: "down regulation of phospholipid efflux" EXACT [GOC:TermGenie]
synonym: "down regulation of phospholipid export" EXACT [GOC:TermGenie]
synonym: "down-regulation of phospholipid efflux" EXACT [GOC:TermGenie]
synonym: "down-regulation of phospholipid export" EXACT [GOC:TermGenie]
synonym: "downregulation of phospholipid efflux" EXACT [GOC:TermGenie]
synonym: "downregulation of phospholipid export" EXACT [GOC:TermGenie]
synonym: "inhibition of phospholipid efflux" NARROW [GOC:TermGenie]
synonym: "inhibition of phospholipid export" NARROW [GOC:TermGenie]
synonym: "negative regulation of phospholipid export" EXACT [GOC:TermGenie]
is_a: GO:1902994 ! regulation of phospholipid efflux
is_a: GO:2001139 ! negative regulation of phospholipid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0033700 ! phospholipid efflux
relationship: negatively_regulates GO:0033700 ! phospholipid efflux
created_by: sjp
creation_date: 2014-05-09T08:09:59Z

[Term]
id: GO:1903000
name: regulation of lipid transport across blood brain barrier
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lipid transport across blood brain barrier." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:24345162]
is_a: GO:0032368 ! regulation of lipid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990379 ! lipid transport across blood brain barrier
relationship: regulates GO:1990379 ! lipid transport across blood brain barrier
created_by: sjp
creation_date: 2014-05-09T09:30:04Z

[Term]
id: GO:1903001
name: negative regulation of lipid transport across blood brain barrier
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lipid transport across blood brain barrier." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:24345162]
synonym: "down regulation of lipid transport across blood brain barrier" EXACT [GOC:TermGenie]
synonym: "down-regulation of lipid transport across blood brain barrier" EXACT [GOC:TermGenie]
synonym: "downregulation of lipid transport across blood brain barrier" EXACT [GOC:TermGenie]
synonym: "inhibition of lipid transport across blood brain barrier" NARROW [GOC:TermGenie]
is_a: GO:0032369 ! negative regulation of lipid transport
is_a: GO:1903000 ! regulation of lipid transport across blood brain barrier
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990379 ! lipid transport across blood brain barrier
relationship: negatively_regulates GO:1990379 ! lipid transport across blood brain barrier
created_by: sjp
creation_date: 2014-05-09T09:30:10Z

[Term]
id: GO:1903002
name: positive regulation of lipid transport across blood brain barrier
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lipid transport across blood brain barrier." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:24345162]
synonym: "activation of lipid transport across blood brain barrier" NARROW [GOC:TermGenie]
synonym: "up regulation of lipid transport across blood brain barrier" EXACT [GOC:TermGenie]
synonym: "up-regulation of lipid transport across blood brain barrier" EXACT [GOC:TermGenie]
synonym: "upregulation of lipid transport across blood brain barrier" EXACT [GOC:TermGenie]
is_a: GO:0032370 ! positive regulation of lipid transport
is_a: GO:1903000 ! regulation of lipid transport across blood brain barrier
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990379 ! lipid transport across blood brain barrier
relationship: positively_regulates GO:1990379 ! lipid transport across blood brain barrier
created_by: sjp
creation_date: 2014-05-09T09:30:16Z

[Term]
id: GO:1903003
name: positive regulation of protein deubiquitination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein deubiquitination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22970133]
synonym: "activation of deubiquitination" NARROW [GOC:TermGenie]
synonym: "activation of protein deubiquitination" NARROW [GOC:TermGenie]
synonym: "activation of protein deubiquitinylation" NARROW [GOC:TermGenie]
synonym: "activation of protein deubiquitylation" NARROW [GOC:TermGenie]
synonym: "positive regulation of deubiquitination" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein deubiquitinylation" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein deubiquitylation" EXACT [GOC:TermGenie]
synonym: "up regulation of deubiquitination" EXACT [GOC:TermGenie]
synonym: "up regulation of protein deubiquitination" EXACT [GOC:TermGenie]
synonym: "up regulation of protein deubiquitinylation" EXACT [GOC:TermGenie]
synonym: "up regulation of protein deubiquitylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of deubiquitination" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein deubiquitination" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein deubiquitinylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein deubiquitylation" EXACT [GOC:TermGenie]
synonym: "upregulation of deubiquitination" EXACT [GOC:TermGenie]
synonym: "upregulation of protein deubiquitination" EXACT [GOC:TermGenie]
synonym: "upregulation of protein deubiquitinylation" EXACT [GOC:TermGenie]
synonym: "upregulation of protein deubiquitylation" EXACT [GOC:TermGenie]
is_a: GO:0045862 ! positive regulation of proteolysis
is_a: GO:0090085 ! regulation of protein deubiquitination
is_a: GO:1903322 ! positive regulation of protein modification by small protein conjugation or removal
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016579 ! protein deubiquitination
relationship: positively_regulates GO:0016579 ! protein deubiquitination
created_by: bf
creation_date: 2014-05-12T15:39:10Z

[Term]
id: GO:1903004
name: regulation of protein K63-linked deubiquitination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein K63-linked deubiquitination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22970133]
is_a: GO:0090085 ! regulation of protein deubiquitination
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070536 ! protein K63-linked deubiquitination
relationship: regulates GO:0070536 ! protein K63-linked deubiquitination
created_by: bf
creation_date: 2014-05-12T15:40:43Z

[Term]
id: GO:1903005
name: negative regulation of protein K63-linked deubiquitination
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein K63-linked deubiquitination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22970133]
synonym: "down regulation of protein K63-linked deubiquitination" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein K63-linked deubiquitination" EXACT [GOC:TermGenie]
synonym: "downregulation of protein K63-linked deubiquitination" EXACT [GOC:TermGenie]
synonym: "inhibition of protein K63-linked deubiquitination" NARROW [GOC:TermGenie]
is_a: GO:0090086 ! negative regulation of protein deubiquitination
is_a: GO:1903004 ! regulation of protein K63-linked deubiquitination
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070536 ! protein K63-linked deubiquitination
relationship: negatively_regulates GO:0070536 ! protein K63-linked deubiquitination
created_by: bf
creation_date: 2014-05-12T15:40:49Z

[Term]
id: GO:1903006
name: positive regulation of protein K63-linked deubiquitination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein K63-linked deubiquitination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22970133]
synonym: "activation of protein K63-linked deubiquitination" NARROW [GOC:TermGenie]
synonym: "up regulation of protein K63-linked deubiquitination" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein K63-linked deubiquitination" EXACT [GOC:TermGenie]
synonym: "upregulation of protein K63-linked deubiquitination" EXACT [GOC:TermGenie]
is_a: GO:1903003 ! positive regulation of protein deubiquitination
is_a: GO:1903004 ! regulation of protein K63-linked deubiquitination
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070536 ! protein K63-linked deubiquitination
relationship: positively_regulates GO:0070536 ! protein K63-linked deubiquitination
created_by: bf
creation_date: 2014-05-12T15:40:55Z

[Term]
id: GO:1903007
name: positive regulation of Lys63-specific deubiquitinase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of Lys63-specific deubiquitinase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22970133]
synonym: "activation of Lys63-specific deubiquitinase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of Lys63-specific deubiquitinase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of Lys63-specific deubiquitinase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of Lys63-specific deubiquitinase activity" EXACT [GOC:TermGenie]
is_a: GO:1903006 ! positive regulation of protein K63-linked deubiquitination
is_a: GO:2000158 ! positive regulation of ubiquitin-specific protease activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061578 ! Lys63-specific deubiquitinase activity
relationship: positively_regulates GO:0061578 ! Lys63-specific deubiquitinase activity
created_by: bf
creation_date: 2014-05-12T15:47:35Z

[Term]
id: GO:1903008
name: organelle disassembly
namespace: biological_process
def: "The disaggregation of an organelle into its constituent components." [GO_REF:0000079, GOC:TermGenie]
synonym: "organelle degradation" EXACT []
is_a: GO:0022411 ! cellular component disassembly
is_a: GO:1902589 ! single-organism organelle organization
created_by: jl
creation_date: 2014-05-13T12:36:03Z

[Term]
id: GO:1903009
name: proteasome complex disassembly
namespace: biological_process
def: "The disaggregation of a proteasome complex into its constituent components." [GO_REF:0000079, GOC:TermGenie]
synonym: "26S proteasome disassembly" NARROW [GOC:TermGenie]
synonym: "proteasome degradation" EXACT []
synonym: "proteasome disassembly" EXACT [GOC:TermGenie]
is_a: GO:0043241 ! protein complex disassembly
created_by: jl
creation_date: 2014-05-13T12:41:59Z

[Term]
id: GO:1903010
name: regulation of bone development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of bone development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:22510437]
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060348 ! bone development
relationship: regulates GO:0060348 ! bone development
created_by: mr
creation_date: 2014-05-13T22:41:53Z

[Term]
id: GO:1903011
name: negative regulation of bone development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of bone development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:22510437]
synonym: "down regulation of bone development" EXACT [GOC:TermGenie]
synonym: "down-regulation of bone development" EXACT [GOC:TermGenie]
synonym: "downregulation of bone development" EXACT [GOC:TermGenie]
synonym: "inhibition of bone development" NARROW [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1903010 ! regulation of bone development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060348 ! bone development
relationship: negatively_regulates GO:0060348 ! bone development
created_by: mr
creation_date: 2014-05-13T22:42:00Z

[Term]
id: GO:1903012
name: positive regulation of bone development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of bone development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:22510437]
synonym: "activation of bone development" NARROW [GOC:TermGenie]
synonym: "up regulation of bone development" EXACT [GOC:TermGenie]
synonym: "up-regulation of bone development" EXACT [GOC:TermGenie]
synonym: "upregulation of bone development" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1903010 ! regulation of bone development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060348 ! bone development
relationship: positively_regulates GO:0060348 ! bone development
created_by: mr
creation_date: 2014-05-13T22:42:06Z

[Term]
id: GO:1903013
name: response to 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22365144]
synonym: "DIF-1" RELATED []
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0045472 ! response to ether
is_a: GO:1901654 ! response to ketone
created_by: rjd
creation_date: 2014-05-14T16:18:11Z

[Term]
id: GO:1903014
name: cellular response to 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22365144]
synonym: "DIF-1" RELATED []
is_a: GO:0071362 ! cellular response to ether
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901655 ! cellular response to ketone
is_a: GO:1903013 ! response to 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one
created_by: rjd
creation_date: 2014-05-14T16:18:18Z

[Term]
id: GO:1903015
name: regulation of exo-alpha-sialidase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of exo-alpha-sialidase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23544079]
comment: human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) demonstrated in Figure 4A PMID:23544079, (IDA)
synonym: "regulation of acetylneuraminidase activity" EXACT [GOC:TermGenie]
synonym: "regulation of acetylneuraminyl hydrolase activity" EXACT [GOC:TermGenie]
synonym: "regulation of alpha-neuraminidase activity" EXACT [GOC:TermGenie]
synonym: "regulation of N-acylneuraminate glycohydrolase activity" EXACT [GOC:TermGenie]
synonym: "regulation of neuraminidase activity" EXACT [GOC:TermGenie]
synonym: "regulation of sialidase activity" EXACT [GOC:TermGenie]
is_a: GO:0051336 ! regulation of hydrolase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004308 ! exo-alpha-sialidase activity
relationship: regulates GO:0004308 ! exo-alpha-sialidase activity
created_by: rl
creation_date: 2014-05-14T18:15:11Z

[Term]
id: GO:1903016
name: negative regulation of exo-alpha-sialidase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of exo-alpha-sialidase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23544079]
comment: human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) demonstrated in Figure 4A PMID:23544079, (IDA)
synonym: "down regulation of acetylneuraminidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of acetylneuraminyl hydrolase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of alpha-neuraminidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of exo-alpha-sialidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of N-acylneuraminate glycohydrolase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of neuraminidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of sialidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of acetylneuraminidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of acetylneuraminyl hydrolase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of alpha-neuraminidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of exo-alpha-sialidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of N-acylneuraminate glycohydrolase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of neuraminidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of sialidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of acetylneuraminidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of acetylneuraminyl hydrolase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of alpha-neuraminidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of exo-alpha-sialidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of N-acylneuraminate glycohydrolase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of neuraminidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of sialidase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of acetylneuraminidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of acetylneuraminyl hydrolase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of alpha-neuraminidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of exo-alpha-sialidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of N-acylneuraminate glycohydrolase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of neuraminidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of sialidase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of acetylneuraminidase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of acetylneuraminyl hydrolase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of alpha-neuraminidase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of N-acylneuraminate glycohydrolase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of neuraminidase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of sialidase activity" EXACT [GOC:TermGenie]
is_a: GO:0051346 ! negative regulation of hydrolase activity
is_a: GO:1903015 ! regulation of exo-alpha-sialidase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004308 ! exo-alpha-sialidase activity
relationship: negatively_regulates GO:0004308 ! exo-alpha-sialidase activity
created_by: rl
creation_date: 2014-05-14T18:15:17Z

[Term]
id: GO:1903017
name: positive regulation of exo-alpha-sialidase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of exo-alpha-sialidase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23544079]
comment: human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) demonstrated in Figure 4A PMID:23544079, (IDA)
synonym: "activation of acetylneuraminidase activity" NARROW [GOC:TermGenie]
synonym: "activation of acetylneuraminyl hydrolase activity" NARROW [GOC:TermGenie]
synonym: "activation of alpha-neuraminidase activity" NARROW [GOC:TermGenie]
synonym: "activation of exo-alpha-sialidase activity" NARROW [GOC:TermGenie]
synonym: "activation of N-acylneuraminate glycohydrolase activity" NARROW [GOC:TermGenie]
synonym: "activation of neuraminidase activity" NARROW [GOC:TermGenie]
synonym: "activation of sialidase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of acetylneuraminidase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of acetylneuraminyl hydrolase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of alpha-neuraminidase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of N-acylneuraminate glycohydrolase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of neuraminidase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of sialidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of acetylneuraminidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of acetylneuraminyl hydrolase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of alpha-neuraminidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of exo-alpha-sialidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of N-acylneuraminate glycohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of neuraminidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of sialidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of acetylneuraminidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of acetylneuraminyl hydrolase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of alpha-neuraminidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of exo-alpha-sialidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of N-acylneuraminate glycohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of neuraminidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of sialidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of acetylneuraminidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of acetylneuraminyl hydrolase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of alpha-neuraminidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of exo-alpha-sialidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of N-acylneuraminate glycohydrolase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of neuraminidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of sialidase activity" EXACT [GOC:TermGenie]
is_a: GO:0051345 ! positive regulation of hydrolase activity
is_a: GO:1903015 ! regulation of exo-alpha-sialidase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004308 ! exo-alpha-sialidase activity
relationship: positively_regulates GO:0004308 ! exo-alpha-sialidase activity
created_by: rl
creation_date: 2014-05-14T18:15:23Z

[Term]
id: GO:1903018
name: regulation of glycoprotein metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glycoprotein metabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23544079]
comment: human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) and thus the metabolism of glycoproteins, demonstrated in Figure 4A PMID:23544079, (IDA), the negative regulation term would be applied to this protein
synonym: "regulation of glycoprotein metabolism" EXACT [GOC:TermGenie]
is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:0051246 ! regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009100 ! glycoprotein metabolic process
relationship: regulates GO:0009100 ! glycoprotein metabolic process
created_by: rl
creation_date: 2014-05-14T18:44:19Z

[Term]
id: GO:1903019
name: negative regulation of glycoprotein metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glycoprotein metabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23544079]
comment: human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) and thus the metabolism of glycoproteins, demonstrated in Figure 4A PMID:23544079, (IDA), the negative regulation term would be applied to this protein
synonym: "down regulation of glycoprotein metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of glycoprotein metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of glycoprotein metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of glycoprotein metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of glycoprotein metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of glycoprotein metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of glycoprotein metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of glycoprotein metabolism" NARROW [GOC:TermGenie]
synonym: "negative regulation of glycoprotein metabolism" EXACT [GOC:TermGenie]
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0051248 ! negative regulation of protein metabolic process
is_a: GO:1903018 ! regulation of glycoprotein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009100 ! glycoprotein metabolic process
relationship: negatively_regulates GO:0009100 ! glycoprotein metabolic process
created_by: rl
creation_date: 2014-05-14T18:44:25Z

[Term]
id: GO:1903020
name: positive regulation of glycoprotein metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glycoprotein metabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23544079]
comment: human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) and thus the metabolism of glycoproteins, demonstrated in Figure 4A PMID:23544079, (IDA), the negative regulation term would be applied to this protein
synonym: "activation of glycoprotein metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of glycoprotein metabolism" NARROW [GOC:TermGenie]
synonym: "positive regulation of glycoprotein metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of glycoprotein metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of glycoprotein metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of glycoprotein metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of glycoprotein metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of glycoprotein metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of glycoprotein metabolism" EXACT [GOC:TermGenie]
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0051247 ! positive regulation of protein metabolic process
is_a: GO:1903018 ! regulation of glycoprotein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009100 ! glycoprotein metabolic process
relationship: positively_regulates GO:0009100 ! glycoprotein metabolic process
created_by: rl
creation_date: 2014-05-14T18:44:31Z

[Term]
id: GO:1903021
name: regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands." [GO_REF:0000059, GOC:rb, GOC:TermGenie, PMID:12192046]
is_a: GO:0051336 ! regulation of hydrolase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0090580 ! phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands
relationship: regulates GO:0090580 ! phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands
created_by: tb
creation_date: 2014-05-14T23:44:35Z

[Term]
id: GO:1903022
name: positive regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands." [GO_REF:0000059, GOC:rb, GOC:TermGenie, PMID:12192046]
synonym: "activation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands" NARROW [GOC:TermGenie]
synonym: "up regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands" EXACT [GOC:TermGenie]
is_a: GO:0051345 ! positive regulation of hydrolase activity
is_a: GO:1903021 ! regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0090580 ! phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands
relationship: positively_regulates GO:0090580 ! phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands
created_by: tb
creation_date: 2014-05-14T23:44:47Z

[Term]
id: GO:1903023
name: regulation of ascospore-type prospore membrane assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ascospore-type prospore membrane assembly." [GO_REF:0000058, GOC:TermGenie, PMID:11405625]
synonym: "regulation of forespore membrane biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of forespore membrane formation" EXACT [GOC:TermGenie]
synonym: "regulation of FSM assembly" EXACT [GOC:TermGenie]
synonym: "regulation of FSM biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of FSM formation" EXACT [GOC:TermGenie]
is_a: GO:0034307 ! regulation of ascospore formation
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032120 ! ascospore-type prospore membrane assembly
relationship: regulates GO:0032120 ! ascospore-type prospore membrane assembly
created_by: al
creation_date: 2014-05-15T08:51:51Z

[Term]
id: GO:1903024
name: positive regulation of ascospore-type prospore membrane assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ascospore-type prospore membrane assembly." [GO_REF:0000058, GOC:TermGenie, PMID:11405625]
synonym: "activation of ascospore-type prospore membrane assembly" NARROW [GOC:TermGenie]
synonym: "activation of forespore membrane biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of forespore membrane formation" NARROW [GOC:TermGenie]
synonym: "activation of FSM assembly" NARROW [GOC:TermGenie]
synonym: "activation of FSM biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of FSM formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of forespore membrane biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of forespore membrane formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of FSM assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of FSM biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of FSM formation" EXACT [GOC:TermGenie]
synonym: "up regulation of ascospore-type prospore membrane assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of forespore membrane biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of forespore membrane formation" EXACT [GOC:TermGenie]
synonym: "up regulation of FSM assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of FSM biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of FSM formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of ascospore-type prospore membrane assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of forespore membrane biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of forespore membrane formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of FSM assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of FSM biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of FSM formation" EXACT [GOC:TermGenie]
synonym: "upregulation of ascospore-type prospore membrane assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of forespore membrane biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of forespore membrane formation" EXACT [GOC:TermGenie]
synonym: "upregulation of FSM assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of FSM biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of FSM formation" EXACT [GOC:TermGenie]
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:0075296 ! positive regulation of ascospore formation
is_a: GO:1903023 ! regulation of ascospore-type prospore membrane assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032120 ! ascospore-type prospore membrane assembly
relationship: positively_regulates GO:0032120 ! ascospore-type prospore membrane assembly
created_by: al
creation_date: 2014-05-15T08:51:58Z

[Term]
id: GO:1903025
name: regulation of RNA polymerase II regulatory region sequence-specific DNA binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of RNA polymerase II regulatory region sequence-specific DNA binding." [GO_REF:0000059, GOC:dph, GOC:krc, GOC:TermGenie, PMID:20026326]
is_a: GO:2000677 ! regulation of transcription regulatory region DNA binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000977 ! RNA polymerase II regulatory region sequence-specific DNA binding
relationship: regulates GO:0000977 ! RNA polymerase II regulatory region sequence-specific DNA binding
created_by: dph
creation_date: 2014-05-15T17:55:54Z

[Term]
id: GO:1903026
name: negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA polymerase II regulatory region sequence-specific DNA binding." [GO_REF:0000059, GOC:dph, GOC:krc, GOC:TermGenie, PMID:20026326]
synonym: "down regulation of RNA polymerase II regulatory region sequence-specific DNA binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA polymerase II regulatory region sequence-specific DNA binding" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA polymerase II regulatory region sequence-specific DNA binding" EXACT [GOC:TermGenie]
synonym: "inhibition of RNA polymerase II regulatory region sequence-specific DNA binding" NARROW [GOC:TermGenie]
is_a: GO:1903025 ! regulation of RNA polymerase II regulatory region sequence-specific DNA binding
is_a: GO:2000678 ! negative regulation of transcription regulatory region DNA binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000977 ! RNA polymerase II regulatory region sequence-specific DNA binding
relationship: negatively_regulates GO:0000977 ! RNA polymerase II regulatory region sequence-specific DNA binding
created_by: dph
creation_date: 2014-05-15T17:56:00Z

[Term]
id: GO:1903027
name: regulation of opsonization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of opsonization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22333221]
is_a: GO:0002697 ! regulation of immune effector process
is_a: GO:0050764 ! regulation of phagocytosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008228 ! opsonization
relationship: regulates GO:0008228 ! opsonization
created_by: rl
creation_date: 2014-05-16T17:34:41Z

[Term]
id: GO:1903028
name: positive regulation of opsonization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of opsonization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22333221]
synonym: "activation of opsonization" NARROW [GOC:TermGenie]
synonym: "up regulation of opsonization" EXACT [GOC:TermGenie]
synonym: "up-regulation of opsonization" EXACT [GOC:TermGenie]
synonym: "upregulation of opsonization" EXACT [GOC:TermGenie]
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0050766 ! positive regulation of phagocytosis
is_a: GO:1903027 ! regulation of opsonization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008228 ! opsonization
relationship: positively_regulates GO:0008228 ! opsonization
created_by: rl
creation_date: 2014-05-16T17:34:54Z

[Term]
id: GO:1903031
name: regulation of microtubule plus-end binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of microtubule plus-end binding." [GO_REF:0000059, GOC:hjd, GOC:TermGenie, PMID:16148041]
is_a: GO:1904526 ! regulation of microtubule binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051010 ! microtubule plus-end binding
relationship: regulates GO:0051010 ! microtubule plus-end binding
created_by: hjd
creation_date: 2014-05-16T18:38:26Z

[Term]
id: GO:1903032
name: negative regulation of microtubule plus-end binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of microtubule plus-end binding." [GO_REF:0000059, GOC:hjd, GOC:TermGenie, PMID:16148041]
synonym: "down regulation of microtubule plus-end binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of microtubule plus-end binding" EXACT [GOC:TermGenie]
synonym: "downregulation of microtubule plus-end binding" EXACT [GOC:TermGenie]
synonym: "inhibition of microtubule plus-end binding" NARROW [GOC:TermGenie]
is_a: GO:1903031 ! regulation of microtubule plus-end binding
is_a: GO:1904527 ! negative regulation of microtubule binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051010 ! microtubule plus-end binding
relationship: negatively_regulates GO:0051010 ! microtubule plus-end binding
created_by: hjd
creation_date: 2014-05-16T18:38:32Z

[Term]
id: GO:1903033
name: positive regulation of microtubule plus-end binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of microtubule plus-end binding." [GO_REF:0000059, GOC:hjd, GOC:TermGenie, PMID:16148041]
synonym: "activation of microtubule plus-end binding" NARROW [GOC:TermGenie]
synonym: "up regulation of microtubule plus-end binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of microtubule plus-end binding" EXACT [GOC:TermGenie]
synonym: "upregulation of microtubule plus-end binding" EXACT [GOC:TermGenie]
is_a: GO:1903031 ! regulation of microtubule plus-end binding
is_a: GO:1904528 ! positive regulation of microtubule binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051010 ! microtubule plus-end binding
relationship: positively_regulates GO:0051010 ! microtubule plus-end binding
created_by: hjd
creation_date: 2014-05-16T18:38:38Z

[Term]
id: GO:1903034
name: regulation of response to wounding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to wounding." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, pmid:19164535]
synonym: "regulation of physiological response to wounding" EXACT [GOC:TermGenie]
is_a: GO:0080134 ! regulation of response to stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009611 ! response to wounding
relationship: regulates GO:0009611 ! response to wounding
created_by: kmv
creation_date: 2014-05-18T01:28:46Z

[Term]
id: GO:1903035
name: negative regulation of response to wounding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to wounding." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, pmid:19164535]
synonym: "down regulation of physiological response to wounding" EXACT [GOC:TermGenie]
synonym: "down regulation of response to wounding" EXACT [GOC:TermGenie]
synonym: "down-regulation of physiological response to wounding" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to wounding" EXACT [GOC:TermGenie]
synonym: "downregulation of physiological response to wounding" EXACT [GOC:TermGenie]
synonym: "downregulation of response to wounding" EXACT [GOC:TermGenie]
synonym: "inhibition of physiological response to wounding" NARROW [GOC:TermGenie]
synonym: "inhibition of response to wounding" NARROW [GOC:TermGenie]
synonym: "negative regulation of physiological response to wounding" EXACT [GOC:TermGenie]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1903034 ! regulation of response to wounding
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009611 ! response to wounding
relationship: negatively_regulates GO:0009611 ! response to wounding
created_by: kmv
creation_date: 2014-05-18T01:28:52Z

[Term]
id: GO:1903036
name: positive regulation of response to wounding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to wounding." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, pmid:19164535]
synonym: "activation of physiological response to wounding" NARROW [GOC:TermGenie]
synonym: "activation of response to wounding" NARROW [GOC:TermGenie]
synonym: "positive regulation of physiological response to wounding" EXACT [GOC:TermGenie]
synonym: "up regulation of physiological response to wounding" EXACT [GOC:TermGenie]
synonym: "up regulation of response to wounding" EXACT [GOC:TermGenie]
synonym: "up-regulation of physiological response to wounding" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to wounding" EXACT [GOC:TermGenie]
synonym: "upregulation of physiological response to wounding" EXACT [GOC:TermGenie]
synonym: "upregulation of response to wounding" EXACT [GOC:TermGenie]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1903034 ! regulation of response to wounding
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009611 ! response to wounding
relationship: positively_regulates GO:0009611 ! response to wounding
created_by: kmv
creation_date: 2014-05-18T01:28:58Z

[Term]
id: GO:1903037
name: regulation of leukocyte cell-cell adhesion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of leukocyte cell-cell adhesion." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21106532]
comment: Exogenous expression of ASS1 or NOS3 in HUVECs enhances NO production and inhibits monocyte adhesion
synonym: "regulation of leukocyte adhesion" EXACT [GOC:TermGenie]
synonym: "regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie]
is_a: GO:0022407 ! regulation of cell-cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007159 ! leukocyte cell-cell adhesion
relationship: regulates GO:0007159 ! leukocyte cell-cell adhesion
created_by: rl
creation_date: 2014-05-19T15:29:58Z

[Term]
id: GO:1903038
name: negative regulation of leukocyte cell-cell adhesion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte cell-cell adhesion." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21106532]
comment: Exogenous expression of ASS1 or NOS3 in HUVECs enhances NO production and inhibits monocyte adhesion
synonym: "down regulation of leukocyte adhesion" EXACT [GOC:TermGenie]
synonym: "down regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie]
synonym: "down regulation of leukocyte cell-cell adhesion" EXACT [GOC:TermGenie]
synonym: "down-regulation of leukocyte adhesion" EXACT [GOC:TermGenie]
synonym: "down-regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie]
synonym: "down-regulation of leukocyte cell-cell adhesion" EXACT [GOC:TermGenie]
synonym: "downregulation of leukocyte adhesion" EXACT [GOC:TermGenie]
synonym: "downregulation of leukocyte cell adhesion" EXACT [GOC:TermGenie]
synonym: "downregulation of leukocyte cell-cell adhesion" EXACT [GOC:TermGenie]
synonym: "inhibition of leukocyte adhesion" NARROW [GOC:TermGenie]
synonym: "inhibition of leukocyte cell adhesion" NARROW [GOC:TermGenie]
synonym: "inhibition of leukocyte cell-cell adhesion" NARROW [GOC:TermGenie]
synonym: "negative regulation of leukocyte adhesion" EXACT [GOC:TermGenie]
synonym: "negative regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie]
is_a: GO:0022408 ! negative regulation of cell-cell adhesion
is_a: GO:1903037 ! regulation of leukocyte cell-cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007159 ! leukocyte cell-cell adhesion
relationship: negatively_regulates GO:0007159 ! leukocyte cell-cell adhesion
created_by: rl
creation_date: 2014-05-19T15:30:05Z

[Term]
id: GO:1903039
name: positive regulation of leukocyte cell-cell adhesion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of leukocyte cell-cell adhesion." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21106532]
comment: Exogenous expression of ASS1 or NOS3 in HUVECs enhances NO production and inhibits monocyte adhesion
synonym: "activation of leukocyte adhesion" NARROW [GOC:TermGenie]
synonym: "activation of leukocyte cell adhesion" NARROW [GOC:TermGenie]
synonym: "activation of leukocyte cell-cell adhesion" NARROW [GOC:TermGenie]
synonym: "positive regulation of leukocyte adhesion" EXACT [GOC:TermGenie]
synonym: "positive regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie]
synonym: "up regulation of leukocyte adhesion" EXACT [GOC:TermGenie]
synonym: "up regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie]
synonym: "up regulation of leukocyte cell-cell adhesion" EXACT [GOC:TermGenie]
synonym: "up-regulation of leukocyte adhesion" EXACT [GOC:TermGenie]
synonym: "up-regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie]
synonym: "up-regulation of leukocyte cell-cell adhesion" EXACT [GOC:TermGenie]
synonym: "upregulation of leukocyte adhesion" EXACT [GOC:TermGenie]
synonym: "upregulation of leukocyte cell adhesion" EXACT [GOC:TermGenie]
synonym: "upregulation of leukocyte cell-cell adhesion" EXACT [GOC:TermGenie]
is_a: GO:0022409 ! positive regulation of cell-cell adhesion
is_a: GO:1903037 ! regulation of leukocyte cell-cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007159 ! leukocyte cell-cell adhesion
relationship: positively_regulates GO:0007159 ! leukocyte cell-cell adhesion
created_by: rl
creation_date: 2014-05-19T15:30:15Z

[Term]
id: GO:1903040
name: exon-exon junction complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an exon-exon junction complex." [GO_REF:0000079, GOC:sart, GOC:TermGenie, PMID:17606899]
synonym: "EJC assembly" EXACT [GOC:TermGenie]
synonym: "EJC formation" EXACT [GOC:TermGenie]
synonym: "exon-exon junction complex formation" EXACT [GOC:TermGenie]
is_a: GO:0006461 ! protein complex assembly
created_by: sart
creation_date: 2014-05-20T14:52:07Z

[Term]
id: GO:1903041
name: regulation of chondrocyte hypertrophy
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chondrocyte hypertrophy." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:23928032]
is_a: GO:0001558 ! regulation of cell growth
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:0061181 ! regulation of chondrocyte development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003415 ! chondrocyte hypertrophy
relationship: regulates GO:0003415 ! chondrocyte hypertrophy
created_by: mr
creation_date: 2014-05-20T21:23:13Z

[Term]
id: GO:1903042
name: negative regulation of chondrocyte hypertrophy
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chondrocyte hypertrophy." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:23928032]
synonym: "down regulation of chondrocyte hypertrophy" EXACT [GOC:TermGenie]
synonym: "down-regulation of chondrocyte hypertrophy" EXACT [GOC:TermGenie]
synonym: "downregulation of chondrocyte hypertrophy" EXACT [GOC:TermGenie]
synonym: "inhibition of chondrocyte hypertrophy" NARROW [GOC:TermGenie]
is_a: GO:0030308 ! negative regulation of cell growth
is_a: GO:0048640 ! negative regulation of developmental growth
is_a: GO:0061182 ! negative regulation of chondrocyte development
is_a: GO:1903041 ! regulation of chondrocyte hypertrophy
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003415 ! chondrocyte hypertrophy
relationship: negatively_regulates GO:0003415 ! chondrocyte hypertrophy
created_by: mr
creation_date: 2014-05-20T21:23:19Z

[Term]
id: GO:1903043
name: positive regulation of chondrocyte hypertrophy
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chondrocyte hypertrophy." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:23928032]
synonym: "activation of chondrocyte hypertrophy" NARROW [GOC:TermGenie]
synonym: "up regulation of chondrocyte hypertrophy" EXACT [GOC:TermGenie]
synonym: "up-regulation of chondrocyte hypertrophy" EXACT [GOC:TermGenie]
synonym: "upregulation of chondrocyte hypertrophy" EXACT [GOC:TermGenie]
is_a: GO:0030307 ! positive regulation of cell growth
is_a: GO:0048639 ! positive regulation of developmental growth
is_a: GO:1902761 ! positive regulation of chondrocyte development
is_a: GO:1903041 ! regulation of chondrocyte hypertrophy
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003415 ! chondrocyte hypertrophy
relationship: positively_regulates GO:0003415 ! chondrocyte hypertrophy
created_by: mr
creation_date: 2014-05-20T21:23:25Z

[Term]
id: GO:1903044
name: protein localization to membrane raft
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a membrane raft." [GO_REF:0000087, GOC:dl, GOC:TermGenie, PMID:19414744]
synonym: "protein localisation in membrane raft" EXACT [GOC:TermGenie]
synonym: "protein localisation to membrane raft" EXACT [GOC:TermGenie]
synonym: "protein localization in membrane raft" EXACT [GOC:TermGenie]
is_a: GO:0072657 ! protein localization to membrane
created_by: dl
creation_date: 2014-05-21T10:49:03Z

[Term]
id: GO:1903045
name: neural crest cell migration involved in sympathetic nervous system development
namespace: biological_process
def: "Any neural crest cell migration that is involved in sympathetic nervous system development." [GO_REF:0000060, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19325129]
comment: Sema3a (O08665, mouse) is involved in neural crest cell migration involved in sympathetic nervous system development
is_a: GO:1901166 ! neural crest cell migration involved in autonomic nervous system development
intersection_of: GO:0001755 ! neural crest cell migration
intersection_of: part_of GO:0048485 ! sympathetic nervous system development
relationship: part_of GO:0048485 ! sympathetic nervous system development
created_by: rl
creation_date: 2014-05-22T07:06:02Z

[Term]
id: GO:1903046
name: meiotic cell cycle process
namespace: biological_process
def: "A process that is part of the meiotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie]
is_a: GO:0022402 ! cell cycle process
is_a: GO:0044702 ! single organism reproductive process
intersection_of: GO:0009987 ! cellular process
intersection_of: part_of GO:0051321 ! meiotic cell cycle
disjoint_from: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:0051321 ! meiotic cell cycle
created_by: jl
creation_date: 2014-05-22T14:22:28Z

[Term]
id: GO:1903047
name: mitotic cell cycle process
namespace: biological_process
def: "A process that is part of the mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie]
is_a: GO:0022402 ! cell cycle process
intersection_of: GO:0009987 ! cellular process
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0000278 ! mitotic cell cycle
created_by: jl
creation_date: 2014-05-22T14:22:34Z

[Term]
id: GO:1903048
name: regulation of acetylcholine-gated cation channel activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of acetylcholine-gated cation channel activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21718690]
is_a: GO:0032412 ! regulation of ion transmembrane transporter activity
is_a: GO:0099601 ! regulation of neurotransmitter receptor activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0022848 ! acetylcholine-gated cation channel activity
relationship: regulates GO:0022848 ! acetylcholine-gated cation channel activity
created_by: bf
creation_date: 2014-05-22T14:46:53Z

[Term]
id: GO:1903049
name: negative regulation of acetylcholine-gated cation channel activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of acetylcholine-gated cation channel activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21718690]
synonym: "down regulation of acetylcholine-gated cation channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of acetylcholine-gated cation channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of acetylcholine-gated cation channel activity" EXACT [GOC:TermGenie]
synonym: "inhibition of acetylcholine-gated cation channel activity" NARROW [GOC:TermGenie]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity
is_a: GO:0050805 ! negative regulation of synaptic transmission
is_a: GO:1903048 ! regulation of acetylcholine-gated cation channel activity
is_a: GO:2000272 ! negative regulation of receptor activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0022848 ! acetylcholine-gated cation channel activity
relationship: negatively_regulates GO:0022848 ! acetylcholine-gated cation channel activity
created_by: bf
creation_date: 2014-05-22T14:47:00Z

[Term]
id: GO:1903050
name: regulation of proteolysis involved in cellular protein catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of proteolysis involved in cellular protein catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18307834]
comment: overexpression of cathepsin C propeptide significantly increased the degradation of of intestinal alkaline phosphatase (IAP)
synonym: "regulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie]
synonym: "regulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie]
synonym: "regulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie]
synonym: "regulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie]
is_a: GO:0030162 ! regulation of proteolysis
is_a: GO:1903362 ! regulation of cellular protein catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051603 ! proteolysis involved in cellular protein catabolic process
relationship: regulates GO:0051603 ! proteolysis involved in cellular protein catabolic process
created_by: rl
creation_date: 2014-05-22T18:00:45Z

[Term]
id: GO:1903051
name: negative regulation of proteolysis involved in cellular protein catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of proteolysis involved in cellular protein catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18307834]
comment: Overexpression of cathepsin C propeptide significantly increased the degradation of intestinal alkaline phosphatase (IAP).
synonym: "down regulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie]
synonym: "down regulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie]
synonym: "down regulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie]
synonym: "down regulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie]
synonym: "down regulation of proteolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie]
synonym: "down-regulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie]
synonym: "down-regulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie]
synonym: "down-regulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie]
synonym: "down-regulation of proteolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie]
synonym: "downregulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie]
synonym: "downregulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie]
synonym: "downregulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie]
synonym: "downregulation of proteolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "inhibition of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie]
synonym: "inhibition of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie]
synonym: "inhibition of peptidolysis involved in cellular protein catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of peptidolysis involved in cellular protein catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie]
synonym: "inhibition of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie]
synonym: "inhibition of proteolysis involved in cellular protein catabolic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie]
synonym: "negative regulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie]
synonym: "negative regulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie]
synonym: "negative regulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie]
is_a: GO:0045861 ! negative regulation of proteolysis
is_a: GO:1903050 ! regulation of proteolysis involved in cellular protein catabolic process
is_a: GO:1903363 ! negative regulation of cellular protein catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051603 ! proteolysis involved in cellular protein catabolic process
relationship: negatively_regulates GO:0051603 ! proteolysis involved in cellular protein catabolic process
created_by: rl
creation_date: 2014-05-22T18:00:51Z

[Term]
id: GO:1903052
name: positive regulation of proteolysis involved in cellular protein catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of proteolysis involved in cellular protein catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18307834]
comment: overexpression of cathepsin C propeptide significantly increased the degradation of of intestinal alkaline phosphatase (IAP)
synonym: "activation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie]
synonym: "activation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie]
synonym: "activation of peptidolysis involved in cellular protein catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of peptidolysis involved in cellular protein catabolism" NARROW [GOC:TermGenie]
synonym: "activation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie]
synonym: "activation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie]
synonym: "activation of proteolysis involved in cellular protein catabolic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie]
synonym: "positive regulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie]
synonym: "positive regulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie]
synonym: "positive regulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie]
synonym: "up regulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie]
synonym: "up regulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie]
synonym: "up regulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie]
synonym: "up regulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie]
synonym: "up regulation of proteolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie]
synonym: "up-regulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie]
synonym: "up-regulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie]
synonym: "up-regulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie]
synonym: "up-regulation of proteolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie]
synonym: "upregulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie]
synonym: "upregulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie]
synonym: "upregulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie]
synonym: "upregulation of proteolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie]
is_a: GO:0045862 ! positive regulation of proteolysis
is_a: GO:1903050 ! regulation of proteolysis involved in cellular protein catabolic process
is_a: GO:1903364 ! positive regulation of cellular protein catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051603 ! proteolysis involved in cellular protein catabolic process
relationship: positively_regulates GO:0051603 ! proteolysis involved in cellular protein catabolic process
created_by: rl
creation_date: 2014-05-22T18:00:57Z

[Term]
id: GO:1903053
name: regulation of extracellular matrix organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of extracellular matrix organization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22357537]
synonym: "regulation of extracellular matrix organisation" EXACT [GOC:TermGenie]
synonym: "regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030198 ! extracellular matrix organization
relationship: regulates GO:0030198 ! extracellular matrix organization
created_by: rl
creation_date: 2014-05-23T17:15:41Z

[Term]
id: GO:1903054
name: negative regulation of extracellular matrix organization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix organization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22357537]
synonym: "down regulation of extracellular matrix organisation" EXACT [GOC:TermGenie]
synonym: "down regulation of extracellular matrix organization" EXACT [GOC:TermGenie]
synonym: "down regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of extracellular matrix organisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of extracellular matrix organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "downregulation of extracellular matrix organisation" EXACT [GOC:TermGenie]
synonym: "downregulation of extracellular matrix organization" EXACT [GOC:TermGenie]
synonym: "downregulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "inhibition of extracellular matrix organisation" NARROW [GOC:TermGenie]
synonym: "inhibition of extracellular matrix organization" NARROW [GOC:TermGenie]
synonym: "inhibition of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of extracellular matrix organisation" EXACT [GOC:TermGenie]
synonym: "negative regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1903053 ! regulation of extracellular matrix organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030198 ! extracellular matrix organization
relationship: negatively_regulates GO:0030198 ! extracellular matrix organization
created_by: rl
creation_date: 2014-05-23T17:15:47Z

[Term]
id: GO:1903055
name: positive regulation of extracellular matrix organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of extracellular matrix organization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22357537]
synonym: "activation of extracellular matrix organisation" NARROW [GOC:TermGenie]
synonym: "activation of extracellular matrix organization" NARROW [GOC:TermGenie]
synonym: "activation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of extracellular matrix organisation" EXACT [GOC:TermGenie]
synonym: "positive regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "up regulation of extracellular matrix organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of extracellular matrix organization" EXACT [GOC:TermGenie]
synonym: "up regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of extracellular matrix organisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of extracellular matrix organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "upregulation of extracellular matrix organisation" EXACT [GOC:TermGenie]
synonym: "upregulation of extracellular matrix organization" EXACT [GOC:TermGenie]
synonym: "upregulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1903053 ! regulation of extracellular matrix organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030198 ! extracellular matrix organization
relationship: positively_regulates GO:0030198 ! extracellular matrix organization
created_by: rl
creation_date: 2014-05-23T17:15:53Z

[Term]
id: GO:1903056
name: regulation of melanosome organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of melanosome organization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:24769727]
comment: Lack of the transcription factor Zeb2 Q9R0G7 leads to spherical melanosomes with irregular borders, in contrast to the rod-shaped melanosomes of ZEB2MCWT hair follicles
synonym: "regulation of melanosome organisation" EXACT [GOC:TermGenie]
synonym: "regulation of melanosome organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0033043 ! regulation of organelle organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032438 ! melanosome organization
relationship: regulates GO:0032438 ! melanosome organization
created_by: rl
creation_date: 2014-05-27T13:27:49Z

[Term]
id: GO:1903057
name: negative regulation of melanosome organization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of melanosome organization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:24769727]
comment: Lack of the transcription factor Zeb2 Q9R0G7 leads to spherical melanosomes with irregular borders, in contrast to the rod-shaped melanosomes of ZEB2MCWT hair follicles.
synonym: "down regulation of melanosome organisation" EXACT [GOC:TermGenie]
synonym: "down regulation of melanosome organization" EXACT [GOC:TermGenie]
synonym: "down regulation of melanosome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of melanosome organisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of melanosome organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of melanosome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "downregulation of melanosome organisation" EXACT [GOC:TermGenie]
synonym: "downregulation of melanosome organization" EXACT [GOC:TermGenie]
synonym: "downregulation of melanosome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "inhibition of melanosome organisation" NARROW [GOC:TermGenie]
synonym: "inhibition of melanosome organization" NARROW [GOC:TermGenie]
synonym: "inhibition of melanosome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of melanosome organisation" EXACT [GOC:TermGenie]
synonym: "negative regulation of melanosome organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:1903056 ! regulation of melanosome organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032438 ! melanosome organization
relationship: negatively_regulates GO:0032438 ! melanosome organization
created_by: rl
creation_date: 2014-05-27T13:27:55Z

[Term]
id: GO:1903058
name: positive regulation of melanosome organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of melanosome organization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:24769727]
comment: Lack of the transcription factor Zeb2 Q9R0G7 leads to spherical melanosomes with irregular borders, in contrast to the rod-shaped melanosomes of ZEB2MCWT hair follicles.
synonym: "activation of melanosome organisation" NARROW [GOC:TermGenie]
synonym: "activation of melanosome organization" NARROW [GOC:TermGenie]
synonym: "activation of melanosome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of melanosome organisation" EXACT [GOC:TermGenie]
synonym: "positive regulation of melanosome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "up regulation of melanosome organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of melanosome organization" EXACT [GOC:TermGenie]
synonym: "up regulation of melanosome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of melanosome organisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of melanosome organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of melanosome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "upregulation of melanosome organisation" EXACT [GOC:TermGenie]
synonym: "upregulation of melanosome organization" EXACT [GOC:TermGenie]
synonym: "upregulation of melanosome organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:1903056 ! regulation of melanosome organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032438 ! melanosome organization
relationship: positively_regulates GO:0032438 ! melanosome organization
created_by: rl
creation_date: 2014-05-27T13:28:01Z

[Term]
id: GO:1903059
name: regulation of protein lipidation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein lipidation." [GO_REF:0000058, GOC:rph, GOC:TermGenie, PMID:21909394]
synonym: "regulation of lipid:protein modification" EXACT [GOC:TermGenie]
synonym: "regulation of protein amino acid lipidation" EXACT [GOC:TermGenie]
is_a: GO:0031399 ! regulation of protein modification process
is_a: GO:0050746 ! regulation of lipoprotein metabolic process
is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006497 ! protein lipidation
relationship: regulates GO:0006497 ! protein lipidation
created_by: rph
creation_date: 2014-05-28T13:21:18Z

[Term]
id: GO:1903060
name: negative regulation of protein lipidation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein lipidation." [GO_REF:0000058, GOC:rph, GOC:TermGenie, PMID:21909394]
synonym: "down regulation of lipid:protein modification" EXACT [GOC:TermGenie]
synonym: "down regulation of protein amino acid lipidation" EXACT [GOC:TermGenie]
synonym: "down regulation of protein lipidation" EXACT [GOC:TermGenie]
synonym: "down-regulation of lipid:protein modification" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein amino acid lipidation" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein lipidation" EXACT [GOC:TermGenie]
synonym: "downregulation of lipid:protein modification" EXACT [GOC:TermGenie]
synonym: "downregulation of protein amino acid lipidation" EXACT [GOC:TermGenie]
synonym: "downregulation of protein lipidation" EXACT [GOC:TermGenie]
synonym: "inhibition of lipid:protein modification" NARROW [GOC:TermGenie]
synonym: "inhibition of protein amino acid lipidation" NARROW [GOC:TermGenie]
synonym: "inhibition of protein lipidation" NARROW [GOC:TermGenie]
synonym: "negative regulation of lipid:protein modification" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein amino acid lipidation" EXACT [GOC:TermGenie]
is_a: GO:0031400 ! negative regulation of protein modification process
is_a: GO:0050748 ! negative regulation of lipoprotein metabolic process
is_a: GO:1903059 ! regulation of protein lipidation
is_a: GO:2000113 ! negative regulation of cellular macromolecule biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006497 ! protein lipidation
relationship: negatively_regulates GO:0006497 ! protein lipidation
created_by: rph
creation_date: 2014-05-28T13:21:25Z

[Term]
id: GO:1903061
name: positive regulation of protein lipidation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein lipidation." [GO_REF:0000058, GOC:rph, GOC:TermGenie, PMID:21909394]
synonym: "activation of lipid:protein modification" NARROW [GOC:TermGenie]
synonym: "activation of protein amino acid lipidation" NARROW [GOC:TermGenie]
synonym: "activation of protein lipidation" NARROW [GOC:TermGenie]
synonym: "positive regulation of lipid:protein modification" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein amino acid lipidation" EXACT [GOC:TermGenie]
synonym: "up regulation of lipid:protein modification" EXACT [GOC:TermGenie]
synonym: "up regulation of protein amino acid lipidation" EXACT [GOC:TermGenie]
synonym: "up regulation of protein lipidation" EXACT [GOC:TermGenie]
synonym: "up-regulation of lipid:protein modification" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein amino acid lipidation" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein lipidation" EXACT [GOC:TermGenie]
synonym: "upregulation of lipid:protein modification" EXACT [GOC:TermGenie]
synonym: "upregulation of protein amino acid lipidation" EXACT [GOC:TermGenie]
synonym: "upregulation of protein lipidation" EXACT [GOC:TermGenie]
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0031401 ! positive regulation of protein modification process
is_a: GO:0050747 ! positive regulation of lipoprotein metabolic process
is_a: GO:1903059 ! regulation of protein lipidation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006497 ! protein lipidation
relationship: positively_regulates GO:0006497 ! protein lipidation
created_by: rph
creation_date: 2014-05-28T13:21:31Z

[Term]
id: GO:1903062
name: regulation of reverse cholesterol transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of reverse cholesterol transport." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23931754]
is_a: GO:0032374 ! regulation of cholesterol transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043691 ! reverse cholesterol transport
relationship: regulates GO:0043691 ! reverse cholesterol transport
created_by: rl
creation_date: 2014-05-28T15:15:27Z

[Term]
id: GO:1903063
name: negative regulation of reverse cholesterol transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of reverse cholesterol transport." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23931754]
synonym: "down regulation of reverse cholesterol transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of reverse cholesterol transport" EXACT [GOC:TermGenie]
synonym: "downregulation of reverse cholesterol transport" EXACT [GOC:TermGenie]
synonym: "inhibition of reverse cholesterol transport" NARROW [GOC:TermGenie]
is_a: GO:0032375 ! negative regulation of cholesterol transport
is_a: GO:1903062 ! regulation of reverse cholesterol transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043691 ! reverse cholesterol transport
relationship: negatively_regulates GO:0043691 ! reverse cholesterol transport
created_by: rl
creation_date: 2014-05-28T15:15:34Z

[Term]
id: GO:1903064
name: positive regulation of reverse cholesterol transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of reverse cholesterol transport." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23931754]
synonym: "activation of reverse cholesterol transport" NARROW [GOC:TermGenie]
synonym: "up regulation of reverse cholesterol transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of reverse cholesterol transport" EXACT [GOC:TermGenie]
synonym: "upregulation of reverse cholesterol transport" EXACT [GOC:TermGenie]
is_a: GO:0032376 ! positive regulation of cholesterol transport
is_a: GO:1903062 ! regulation of reverse cholesterol transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043691 ! reverse cholesterol transport
relationship: positively_regulates GO:0043691 ! reverse cholesterol transport
created_by: rl
creation_date: 2014-05-28T15:15:40Z

[Term]
id: GO:1903065
name: obsolete protein localization to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape
namespace: biological_process
def: "OBSOLETE. Any protein localization to cell tip that is involved in positive regulation of establishment of cell polarity regulating cell shape." [GO_REF:0000060, GOC:TermGenie, PMID:24554432]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "protein localisation to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape" EXACT [GOC:TermGenie]
synonym: "protein localization to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape" EXACT []
is_obsolete: true
created_by: vw
creation_date: 2014-05-28T15:29:27Z

[Term]
id: GO:1903066
name: regulation of protein localization to cell tip
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to cell tip." [GO_REF:0000058, GOC:TermGenie, PMID:24554432]
synonym: "regulation of protein localisation to cell tip" EXACT [GOC:TermGenie]
is_a: GO:1903827 ! regulation of cellular protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990151 ! protein localization to cell tip
relationship: regulates GO:1990151 ! protein localization to cell tip
created_by: vw
creation_date: 2014-05-28T15:48:42Z

[Term]
id: GO:1903067
name: negative regulation of protein localization to cell tip
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell tip." [GO_REF:0000058, GOC:TermGenie, PMID:24554432]
synonym: "down regulation of protein localisation to cell tip" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to cell tip" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation to cell tip" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to cell tip" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation to cell tip" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to cell tip" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localisation to cell tip" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to cell tip" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation to cell tip" EXACT [GOC:TermGenie]
is_a: GO:1903066 ! regulation of protein localization to cell tip
is_a: GO:1903828 ! negative regulation of cellular protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990151 ! protein localization to cell tip
relationship: negatively_regulates GO:1990151 ! protein localization to cell tip
created_by: vw
creation_date: 2014-05-28T15:48:48Z

[Term]
id: GO:1903068
name: positive regulation of protein localization to cell tip
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to cell tip." [GO_REF:0000058, GOC:TermGenie, PMID:24554432]
synonym: "activation of protein localisation to cell tip" NARROW [GOC:TermGenie]
synonym: "activation of protein localization to cell tip" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein localisation to cell tip" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation to cell tip" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to cell tip" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation to cell tip" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to cell tip" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation to cell tip" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to cell tip" EXACT [GOC:TermGenie]
is_a: GO:1903066 ! regulation of protein localization to cell tip
is_a: GO:1903829 ! positive regulation of cellular protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990151 ! protein localization to cell tip
relationship: positively_regulates GO:1990151 ! protein localization to cell tip
created_by: vw
creation_date: 2014-05-28T15:48:54Z

[Term]
id: GO:1903069
name: regulation of ER-associated ubiquitin-dependent protein catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ER-associated ubiquitin-dependent protein catabolic process." [GO_REF:0000058, GOC:rph, GOC:TermGenie, PMID:17872946]
synonym: "regulation of endoplasmic reticulum-associated protein catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of endoplasmic reticulum-associated protein catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of ER-associated protein breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of ER-associated protein catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of ER-associated protein catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of ER-associated protein degradation" EXACT [GOC:TermGenie]
synonym: "regulation of ERAD" EXACT [GOC:TermGenie]
is_a: GO:0032434 ! regulation of proteasomal ubiquitin-dependent protein catabolic process
is_a: GO:1904292 ! regulation of ERAD pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030433 ! ER-associated ubiquitin-dependent protein catabolic process
relationship: regulates GO:0030433 ! ER-associated ubiquitin-dependent protein catabolic process
created_by: rph
creation_date: 2014-05-28T17:53:46Z

[Term]
id: GO:1903070
name: negative regulation of ER-associated ubiquitin-dependent protein catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ER-associated ubiquitin-dependent protein catabolic process." [GO_REF:0000058, GOC:rph, GOC:TermGenie, PMID:17872946]
synonym: "down regulation of endoplasmic reticulum-associated protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of endoplasmic reticulum-associated protein catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of ER-associated protein breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of ER-associated protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of ER-associated protein catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of ER-associated protein degradation" EXACT [GOC:TermGenie]
synonym: "down regulation of ER-associated ubiquitin-dependent protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of ERAD" EXACT [GOC:TermGenie]
synonym: "down-regulation of endoplasmic reticulum-associated protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of endoplasmic reticulum-associated protein catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of ER-associated protein breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of ER-associated protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of ER-associated protein catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of ER-associated protein degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of ER-associated ubiquitin-dependent protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of ERAD" EXACT [GOC:TermGenie]
synonym: "downregulation of endoplasmic reticulum-associated protein catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of endoplasmic reticulum-associated protein catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of ER-associated protein breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of ER-associated protein catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of ER-associated protein catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of ER-associated protein degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of ER-associated ubiquitin-dependent protein catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of ERAD" EXACT [GOC:TermGenie]
synonym: "inhibition of endoplasmic reticulum-associated protein catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of endoplasmic reticulum-associated protein catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of ER-associated protein breakdown" NARROW [GOC:TermGenie]
synonym: "inhibition of ER-associated protein catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of ER-associated protein catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of ER-associated protein degradation" NARROW [GOC:TermGenie]
synonym: "inhibition of ER-associated ubiquitin-dependent protein catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of ERAD" NARROW [GOC:TermGenie]
synonym: "negative regulation of endoplasmic reticulum-associated protein catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of endoplasmic reticulum-associated protein catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of ER-associated protein breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of ER-associated protein catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of ER-associated protein catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of ER-associated protein degradation" EXACT [GOC:TermGenie]
synonym: "negative regulation of ERAD" EXACT [GOC:TermGenie]
is_a: GO:0032435 ! negative regulation of proteasomal ubiquitin-dependent protein catabolic process
is_a: GO:1903069 ! regulation of ER-associated ubiquitin-dependent protein catabolic process
is_a: GO:1904293 ! negative regulation of ERAD pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030433 ! ER-associated ubiquitin-dependent protein catabolic process
relationship: negatively_regulates GO:0030433 ! ER-associated ubiquitin-dependent protein catabolic process
created_by: rph
creation_date: 2014-05-28T17:53:53Z

[Term]
id: GO:1903071
name: positive regulation of ER-associated ubiquitin-dependent protein catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ER-associated ubiquitin-dependent protein catabolic process." [GO_REF:0000058, GOC:rph, GOC:TermGenie, PMID:17872946]
synonym: "activation of endoplasmic reticulum-associated protein catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of endoplasmic reticulum-associated protein catabolism" NARROW [GOC:TermGenie]
synonym: "activation of ER-associated protein breakdown" NARROW [GOC:TermGenie]
synonym: "activation of ER-associated protein catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of ER-associated protein catabolism" NARROW [GOC:TermGenie]
synonym: "activation of ER-associated protein degradation" NARROW [GOC:TermGenie]
synonym: "activation of ER-associated ubiquitin-dependent protein catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of ERAD" NARROW [GOC:TermGenie]
synonym: "positive regulation of endoplasmic reticulum-associated protein catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of endoplasmic reticulum-associated protein catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of ER-associated protein breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of ER-associated protein catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of ER-associated protein catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of ER-associated protein degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of ERAD" EXACT [GOC:TermGenie]
synonym: "up regulation of endoplasmic reticulum-associated protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of endoplasmic reticulum-associated protein catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of ER-associated protein breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of ER-associated protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of ER-associated protein catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of ER-associated protein degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of ER-associated ubiquitin-dependent protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of ERAD" EXACT [GOC:TermGenie]
synonym: "up-regulation of endoplasmic reticulum-associated protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of endoplasmic reticulum-associated protein catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of ER-associated protein breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of ER-associated protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of ER-associated protein catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of ER-associated protein degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of ER-associated ubiquitin-dependent protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of ERAD" EXACT [GOC:TermGenie]
synonym: "upregulation of endoplasmic reticulum-associated protein catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of endoplasmic reticulum-associated protein catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of ER-associated protein breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of ER-associated protein catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of ER-associated protein catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of ER-associated protein degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of ER-associated ubiquitin-dependent protein catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of ERAD" EXACT [GOC:TermGenie]
is_a: GO:0032436 ! positive regulation of proteasomal ubiquitin-dependent protein catabolic process
is_a: GO:1903069 ! regulation of ER-associated ubiquitin-dependent protein catabolic process
is_a: GO:1904294 ! positive regulation of ERAD pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030433 ! ER-associated ubiquitin-dependent protein catabolic process
relationship: positively_regulates GO:0030433 ! ER-associated ubiquitin-dependent protein catabolic process
created_by: rph
creation_date: 2014-05-28T17:54:04Z

[Term]
id: GO:1903072
name: regulation of death-inducing signaling complex assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of death-inducing signaling complex assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21785459]
synonym: "regulation of DD-mediated complex assembly" EXACT [GOC:TermGenie]
synonym: "regulation of death domain-mediated complex assembly" EXACT [GOC:TermGenie]
synonym: "regulation of death domain-mediated complex assembly involved in extrinsic apoptotic pathway" EXACT [GOC:TermGenie]
synonym: "regulation of death-inducing signaling complex formation" EXACT [GOC:TermGenie]
synonym: "regulation of death-inducing signalling complex assembly" EXACT [GOC:TermGenie]
synonym: "regulation of DISC assembly" EXACT [GOC:TermGenie]
synonym: "regulation of DISC formation" EXACT [GOC:TermGenie]
is_a: GO:0043254 ! regulation of protein complex assembly
is_a: GO:2001236 ! regulation of extrinsic apoptotic signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071550 ! death-inducing signaling complex assembly
relationship: regulates GO:0071550 ! death-inducing signaling complex assembly
created_by: bf
creation_date: 2014-05-29T09:33:13Z

[Term]
id: GO:1903073
name: negative regulation of death-inducing signaling complex assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of death-inducing signaling complex assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21785459]
synonym: "down regulation of DD-mediated complex assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of death domain-mediated complex assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of death domain-mediated complex assembly involved in extrinsic apoptotic pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of death-inducing signaling complex assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of death-inducing signaling complex formation" EXACT [GOC:TermGenie]
synonym: "down regulation of death-inducing signalling complex assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of DISC assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of DISC formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of DD-mediated complex assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of death domain-mediated complex assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of death domain-mediated complex assembly involved in extrinsic apoptotic pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of death-inducing signaling complex assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of death-inducing signaling complex formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of death-inducing signalling complex assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of DISC assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of DISC formation" EXACT [GOC:TermGenie]
synonym: "downregulation of DD-mediated complex assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of death domain-mediated complex assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of death domain-mediated complex assembly involved in extrinsic apoptotic pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of death-inducing signaling complex assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of death-inducing signaling complex formation" EXACT [GOC:TermGenie]
synonym: "downregulation of death-inducing signalling complex assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of DISC assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of DISC formation" EXACT [GOC:TermGenie]
synonym: "inhibition of DD-mediated complex assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of death domain-mediated complex assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of death domain-mediated complex assembly involved in extrinsic apoptotic pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of death-inducing signaling complex assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of death-inducing signaling complex formation" NARROW [GOC:TermGenie]
synonym: "inhibition of death-inducing signalling complex assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of DISC assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of DISC formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of DD-mediated complex assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of death domain-mediated complex assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of death domain-mediated complex assembly involved in extrinsic apoptotic pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of death-inducing signaling complex formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of death-inducing signalling complex assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of DISC assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of DISC formation" EXACT [GOC:TermGenie]
is_a: GO:0031333 ! negative regulation of protein complex assembly
is_a: GO:1903072 ! regulation of death-inducing signaling complex assembly
is_a: GO:2001237 ! negative regulation of extrinsic apoptotic signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071550 ! death-inducing signaling complex assembly
relationship: negatively_regulates GO:0071550 ! death-inducing signaling complex assembly
created_by: bf
creation_date: 2014-05-29T09:33:20Z

[Term]
id: GO:1903074
name: TRAIL death-inducing signaling complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a TRAIL death-inducing signaling complex." [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21785459]
synonym: "TRAIL death-inducing signaling complex formation" EXACT [GOC:TermGenie]
synonym: "TRAIL death-inducing signalling complex assembly" EXACT [GOC:TermGenie]
synonym: "TRAIL death-inducing signalling complex formation" EXACT [GOC:TermGenie]
synonym: "TRAIL DISC assembly" EXACT [GOC:TermGenie]
synonym: "TRAIL DISC formation" EXACT [GOC:TermGenie]
is_a: GO:0071550 ! death-inducing signaling complex assembly
relationship: part_of GO:0036462 ! TRAIL-activated apoptotic signaling pathway
created_by: bf
creation_date: 2014-05-29T09:47:39Z

[Term]
id: GO:1903075
name: pyridoxine import into cell
namespace: biological_process
def: "The directed movement of pyridoxine from outside of a cell into the intracellular region of a cell." [GO_REF:0000075, GOC:TermGenie, PMID:15701794]
is_a: GO:0031923 ! pyridoxine transport
created_by: mah
creation_date: 2014-05-29T15:04:14Z

[Term]
id: GO:1903076
name: regulation of protein localization to plasma membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640]
synonym: "regulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie]
synonym: "regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie]
is_a: GO:1903729 ! regulation of plasma membrane organization
is_a: GO:1904375 ! regulation of protein localization to cell periphery
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072659 ! protein localization to plasma membrane
relationship: regulates GO:0072659 ! protein localization to plasma membrane
created_by: rl
creation_date: 2014-05-29T17:10:10Z

[Term]
id: GO:1903077
name: negative regulation of protein localization to plasma membrane
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640]
synonym: "down regulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to plasma membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to plasma membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization in plasma membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to plasma membrane" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localisation in plasma membrane" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization in plasma membrane" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to plasma membrane" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1903076 ! regulation of protein localization to plasma membrane
is_a: GO:1904376 ! negative regulation of protein localization to cell periphery
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072659 ! protein localization to plasma membrane
relationship: negatively_regulates GO:0072659 ! protein localization to plasma membrane
created_by: rl
creation_date: 2014-05-29T17:10:16Z

[Term]
id: GO:1903078
name: positive regulation of protein localization to plasma membrane
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640]
synonym: "activation of protein localisation in plasma membrane" NARROW [GOC:TermGenie]
synonym: "activation of protein localization in plasma membrane" NARROW [GOC:TermGenie]
synonym: "activation of protein localization to plasma membrane" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to plasma membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to plasma membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization in plasma membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to plasma membrane" EXACT [GOC:TermGenie]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1903076 ! regulation of protein localization to plasma membrane
is_a: GO:1904377 ! positive regulation of protein localization to cell periphery
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072659 ! protein localization to plasma membrane
relationship: positively_regulates GO:0072659 ! protein localization to plasma membrane
created_by: rl
creation_date: 2014-05-29T17:10:22Z

[Term]
id: GO:1903079
name: obsolete negative regulation of protein localization to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape
namespace: biological_process
def: "OBSOLETE. Any negative regulation of protein localization to cell tip that is involved in positive regulation of establishment of cell polarity regulating cell shape." [GO_REF:0000060, GOC:TermGenie, PMID:24554432]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "down regulation of protein localisation to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localisation to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localization to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape" EXACT []
is_obsolete: true
created_by: vw
creation_date: 2014-05-29T17:42:24Z

[Term]
id: GO:1903080
name: regulation of C-C chemokine receptor CCR7 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of C-C chemokine receptor CCR7 signaling pathway." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640]
synonym: "regulation of C-C chemokine receptor CCR7 signalling pathway" EXACT [GOC:TermGenie]
synonym: "regulation of CCR7 signaling pathway" RELATED [GOC:TermGenie]
is_a: GO:0070099 ! regulation of chemokine-mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0038118 ! C-C chemokine receptor CCR7 signaling pathway
relationship: regulates GO:0038118 ! C-C chemokine receptor CCR7 signaling pathway
created_by: rl
creation_date: 2014-05-29T18:32:49Z

[Term]
id: GO:1903081
name: negative regulation of C-C chemokine receptor CCR7 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of C-C chemokine receptor CCR7 signaling pathway." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640]
synonym: "down regulation of C-C chemokine receptor CCR7 signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of C-C chemokine receptor CCR7 signalling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of CCR7 signaling pathway" RELATED [GOC:TermGenie]
synonym: "down-regulation of C-C chemokine receptor CCR7 signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of C-C chemokine receptor CCR7 signalling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of CCR7 signaling pathway" RELATED [GOC:TermGenie]
synonym: "downregulation of C-C chemokine receptor CCR7 signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of C-C chemokine receptor CCR7 signalling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of CCR7 signaling pathway" RELATED [GOC:TermGenie]
synonym: "inhibition of C-C chemokine receptor CCR7 signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of C-C chemokine receptor CCR7 signalling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of CCR7 signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of C-C chemokine receptor CCR7 signalling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of CCR7 signaling pathway" RELATED [GOC:TermGenie]
is_a: GO:0070100 ! negative regulation of chemokine-mediated signaling pathway
is_a: GO:1903080 ! regulation of C-C chemokine receptor CCR7 signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0038118 ! C-C chemokine receptor CCR7 signaling pathway
relationship: negatively_regulates GO:0038118 ! C-C chemokine receptor CCR7 signaling pathway
created_by: rl
creation_date: 2014-05-29T18:32:55Z

[Term]
id: GO:1903082
name: positive regulation of C-C chemokine receptor CCR7 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of C-C chemokine receptor CCR7 signaling pathway." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640]
synonym: "activation of C-C chemokine receptor CCR7 signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of C-C chemokine receptor CCR7 signalling pathway" NARROW [GOC:TermGenie]
synonym: "activation of CCR7 signaling pathway" RELATED [GOC:TermGenie]
synonym: "positive regulation of C-C chemokine receptor CCR7 signalling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of CCR7 signaling pathway" RELATED [GOC:TermGenie]
synonym: "up regulation of C-C chemokine receptor CCR7 signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of C-C chemokine receptor CCR7 signalling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of CCR7 signaling pathway" RELATED [GOC:TermGenie]
synonym: "up-regulation of C-C chemokine receptor CCR7 signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of C-C chemokine receptor CCR7 signalling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of CCR7 signaling pathway" RELATED [GOC:TermGenie]
synonym: "upregulation of C-C chemokine receptor CCR7 signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of C-C chemokine receptor CCR7 signalling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of CCR7 signaling pathway" RELATED [GOC:TermGenie]
is_a: GO:0070101 ! positive regulation of chemokine-mediated signaling pathway
is_a: GO:1903080 ! regulation of C-C chemokine receptor CCR7 signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0038118 ! C-C chemokine receptor CCR7 signaling pathway
relationship: positively_regulates GO:0038118 ! C-C chemokine receptor CCR7 signaling pathway
created_by: rl
creation_date: 2014-05-29T18:33:01Z

[Term]
id: GO:1903083
name: protein localization to condensed chromosome
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a condensed chromosome." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, pmid:12707312]
synonym: "protein localisation in condensed chromosome" EXACT [GOC:TermGenie]
synonym: "protein localisation to condensed chromosome" EXACT [GOC:TermGenie]
synonym: "protein localization in condensed chromosome" EXACT [GOC:TermGenie]
is_a: GO:0034502 ! protein localization to chromosome
created_by: kmv
creation_date: 2014-05-29T20:31:25Z

[Term]
id: GO:1903084
name: protein localization to condensed nuclear chromosome
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a condensed nuclear chromosome." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, pmid:12707312]
synonym: "protein localisation in condensed nuclear chromosome" EXACT [GOC:TermGenie]
synonym: "protein localisation to condensed nuclear chromosome" EXACT [GOC:TermGenie]
synonym: "protein localization in condensed nuclear chromosome" EXACT [GOC:TermGenie]
is_a: GO:0034504 ! protein localization to nucleus
is_a: GO:1903083 ! protein localization to condensed chromosome
created_by: kmv
creation_date: 2014-05-29T20:33:17Z

[Term]
id: GO:1903085
name: regulation of sinapate ester biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sinapate ester biosynthesis." [GO_REF:0000058, GOC:TermGenie, PMID:11080161]
synonym: "regulation of sinapate ester anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of sinapate ester biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of sinapate ester formation" EXACT [GOC:TermGenie]
synonym: "regulation of sinapate ester synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
is_a: GO:2000762 ! regulation of phenylpropanoid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0033525 ! sinapate ester biosynthetic process
relationship: regulates GO:0033525 ! sinapate ester biosynthetic process
created_by: tb
creation_date: 2014-05-30T22:00:12Z

[Term]
id: GO:1903086
name: negative regulation of sinapate ester biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sinapate ester biosynthesis." [GO_REF:0000058, GOC:TermGenie, PMID:11080161]
synonym: "down regulation of sinapate ester anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of sinapate ester biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of sinapate ester biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of sinapate ester formation" EXACT [GOC:TermGenie]
synonym: "down regulation of sinapate ester synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of sinapate ester anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of sinapate ester biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of sinapate ester biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of sinapate ester formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of sinapate ester synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of sinapate ester anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of sinapate ester biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of sinapate ester biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of sinapate ester formation" EXACT [GOC:TermGenie]
synonym: "downregulation of sinapate ester synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of sinapate ester anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of sinapate ester biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of sinapate ester biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of sinapate ester formation" NARROW [GOC:TermGenie]
synonym: "inhibition of sinapate ester synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of sinapate ester anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of sinapate ester biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of sinapate ester formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of sinapate ester synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1903085 ! regulation of sinapate ester biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0033525 ! sinapate ester biosynthetic process
relationship: negatively_regulates GO:0033525 ! sinapate ester biosynthetic process
created_by: tb
creation_date: 2014-05-30T22:00:18Z

[Term]
id: GO:1903087
name: mitotic spindle pole body duplication
namespace: biological_process
def: "Any spindle pole body duplication that is involved in the mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "spindle pole body assembly involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "spindle pole body biogenesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "spindle pole body biosynthesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "spindle pole body duplication associated with nuclear envelope involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "spindle pole body duplication in cytoplasm involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "spindle pole body duplication involved in mitotic cell cycle" EXACT []
synonym: "spindle pole body formation involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "spindle pole body replication involved in mitotic cell cycle" EXACT [GOC:TermGenie]
is_a: GO:0030474 ! spindle pole body duplication
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0030474 ! spindle pole body duplication
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0000278 ! mitotic cell cycle
created_by: jl
creation_date: 2014-06-02T16:45:56Z

[Term]
id: GO:1903088
name: 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transport
namespace: biological_process
def: "The directed movement of 5-amino-1-ribofuranosylimidazole-4-carboxamide across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:24778186]
is_a: GO:0042886 ! amide transport
is_a: GO:0045117 ! azole transport
is_a: GO:0055085 ! transmembrane transport
is_a: GO:1901264 ! carbohydrate derivative transport
created_by: mcc
creation_date: 2014-06-02T20:34:58Z

[Term]
id: GO:1903089
name: 5-amino-1-ribofuranosylimidazole-4-carboxamide transporter activity
namespace: molecular_function
def: "Enables the directed movement of 5-amino-1-ribofuranosylimidazole-4-carboxamide into, out of or within a cell, or between cells." [GO_REF:0000066, GOC:TermGenie, PMID:24778186]
synonym: "acadesine transporter activity" EXACT []
is_a: GO:0045118 ! azole transporter activity
is_a: GO:1901505 ! carbohydrate derivative transporter activity
created_by: mcc
creation_date: 2014-06-02T20:37:17Z

[Term]
id: GO:1903090
name: pyridoxal transmembrane transport
namespace: biological_process
def: "The directed movement of pyridoxal across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:15701794]
is_a: GO:0031920 ! pyridoxal transport
is_a: GO:0035461 ! vitamin transmembrane transport
created_by: al
creation_date: 2014-06-03T10:41:13Z

[Term]
id: GO:1903091
name: pyridoxamine transmembrane transport
namespace: biological_process
def: "The directed movement of pyridoxamine across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:15701794]
is_a: GO:0031922 ! pyridoxamine transport
is_a: GO:0035461 ! vitamin transmembrane transport
is_a: GO:0072488 ! ammonium transmembrane transport
created_by: al
creation_date: 2014-06-03T10:41:20Z

[Term]
id: GO:1903092
name: pyridoxine transmembrane transport
namespace: biological_process
def: "The directed movement of pyridoxine across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:15701794]
is_a: GO:0031923 ! pyridoxine transport
is_a: GO:0035461 ! vitamin transmembrane transport
created_by: al
creation_date: 2014-06-03T10:41:26Z

[Term]
id: GO:1903093
name: regulation of protein K48-linked deubiquitination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein K48-linked deubiquitination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
is_a: GO:0090085 ! regulation of protein deubiquitination
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071108 ! protein K48-linked deubiquitination
relationship: regulates GO:0071108 ! protein K48-linked deubiquitination
created_by: bf
creation_date: 2014-06-03T12:27:48Z

[Term]
id: GO:1903094
name: negative regulation of protein K48-linked deubiquitination
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein K48-linked deubiquitination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21097510]
synonym: "down regulation of protein K48-linked deubiquitination" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein K48-linked deubiquitination" EXACT [GOC:TermGenie]
synonym: "downregulation of protein K48-linked deubiquitination" EXACT [GOC:TermGenie]
synonym: "inhibition of protein K48-linked deubiquitination" NARROW [GOC:TermGenie]
is_a: GO:0090086 ! negative regulation of protein deubiquitination
is_a: GO:1903093 ! regulation of protein K48-linked deubiquitination
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071108 ! protein K48-linked deubiquitination
relationship: negatively_regulates GO:0071108 ! protein K48-linked deubiquitination
created_by: bf
creation_date: 2014-06-03T12:27:54Z

[Term]
id: GO:1903095
name: ribonuclease III complex
namespace: cellular_component
def: "A protein complex which is capable of ribonuclease III activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:22393237]
comment: An example of this is RNC in human (Q9NRR4) in PMID:22393237 (inferred from direct assay).
is_a: GO:1902555 ! endoribonuclease complex
created_by: bhm
creation_date: 2014-06-03T15:06:39Z

[Term]
id: GO:1903096
name: protein localization to meiotic spindle midzone
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a meiotic spindle midzone." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, pmid:12707312]
synonym: "protein localisation in meiotic spindle midzone" EXACT [GOC:TermGenie]
synonym: "protein localisation to meiotic spindle midzone" EXACT [GOC:TermGenie]
synonym: "protein localization in meiotic spindle midzone" EXACT [GOC:TermGenie]
is_a: GO:0072698 ! protein localization to microtubule cytoskeleton
created_by: kmv
creation_date: 2014-06-03T16:06:22Z

[Term]
id: GO:1903097
name: regulation of CENP-A containing nucleosome assembly
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the formation of nucleosomes containing the histone H3 variant CENP-A to form centromeric chromatin. This specialised chromatin occurs at centromeric region in point centromeres,  and the central core in modular centromeres." [GO_REF:0000058, GOC:TermGenie, PMID:24710126]
synonym: "regulation of CenH3-containing nucleosome assembly at centromere" RELATED [GOC:TermGenie]
synonym: "regulation of CENP-A deposition" RELATED [GOC:TermGenie]
synonym: "regulation of CENP-A loading" RELATED [GOC:TermGenie]
synonym: "regulation of centromere specific nucleosome exchange" RELATED [GOC:TermGenie]
synonym: "regulation of centromere-specific histone exchange" EXACT [GOC:TermGenie]
synonym: "regulation of centromere-specific nucleosome assembly" EXACT [GOC:TermGenie]
synonym: "regulation of centromeric DNA replication-independent nucleosome assembly" EXACT [GOC:TermGenie]
synonym: "regulation of DNA replication-independent nucleosome assembly at centromere" EXACT [GOC:TermGenie]
is_a: GO:0010847 ! regulation of chromatin assembly
is_a: GO:0043254 ! regulation of protein complex assembly
is_a: GO:0090230 ! regulation of centromere complex assembly
is_a: GO:1900049 ! regulation of histone exchange
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034080 ! CENP-A containing nucleosome assembly
relationship: regulates GO:0034080 ! CENP-A containing nucleosome assembly
created_by: vw
creation_date: 2014-06-03T16:15:30Z

[Term]
id: GO:1903098
name: negative regulation of CENP-A containing nucleosome assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the formation of nucleosomes containing the histone H3 variant CENP-A to form centromeric chromatin. This specialised chromatin occurs at centromeric region in point centromeres,  and the central core in modular centromeres." [GO_REF:0000058, GOC:TermGenie, PMID:24710126]
synonym: "down regulation of CenH3-containing nucleosome assembly at centromere" RELATED [GOC:TermGenie]
synonym: "down regulation of CENP-A containing nucleosome assembly at centromere" EXACT [GOC:TermGenie]
synonym: "down regulation of CENP-A deposition" RELATED [GOC:TermGenie]
synonym: "down regulation of CENP-A loading" RELATED [GOC:TermGenie]
synonym: "down regulation of centromere specific nucleosome exchange" RELATED [GOC:TermGenie]
synonym: "down regulation of centromere-specific histone exchange" EXACT [GOC:TermGenie]
synonym: "down regulation of centromere-specific nucleosome assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of centromeric DNA replication-independent nucleosome assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of DNA replication-independent nucleosome assembly at centromere" EXACT [GOC:TermGenie]
synonym: "down-regulation of CenH3-containing nucleosome assembly at centromere" RELATED [GOC:TermGenie]
synonym: "down-regulation of CENP-A containing nucleosome assembly at centromere" EXACT [GOC:TermGenie]
synonym: "down-regulation of CENP-A deposition" RELATED [GOC:TermGenie]
synonym: "down-regulation of CENP-A loading" RELATED [GOC:TermGenie]
synonym: "down-regulation of centromere specific nucleosome exchange" RELATED [GOC:TermGenie]
synonym: "down-regulation of centromere-specific histone exchange" EXACT [GOC:TermGenie]
synonym: "down-regulation of centromere-specific nucleosome assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of centromeric DNA replication-independent nucleosome assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA replication-independent nucleosome assembly at centromere" EXACT [GOC:TermGenie]
synonym: "downregulation of CenH3-containing nucleosome assembly at centromere" RELATED [GOC:TermGenie]
synonym: "downregulation of CENP-A containing nucleosome assembly at centromere" EXACT [GOC:TermGenie]
synonym: "downregulation of CENP-A deposition" RELATED [GOC:TermGenie]
synonym: "downregulation of CENP-A loading" RELATED [GOC:TermGenie]
synonym: "downregulation of centromere specific nucleosome exchange" RELATED [GOC:TermGenie]
synonym: "downregulation of centromere-specific histone exchange" EXACT [GOC:TermGenie]
synonym: "downregulation of centromere-specific nucleosome assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of centromeric DNA replication-independent nucleosome assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA replication-independent nucleosome assembly at centromere" EXACT [GOC:TermGenie]
synonym: "inhibition of CenH3-containing nucleosome assembly at centromere" RELATED [GOC:TermGenie]
synonym: "inhibition of CENP-A containing nucleosome assembly at centromere" NARROW [GOC:TermGenie]
synonym: "inhibition of CENP-A deposition" RELATED [GOC:TermGenie]
synonym: "inhibition of CENP-A loading" RELATED [GOC:TermGenie]
synonym: "inhibition of centromere specific nucleosome exchange" RELATED [GOC:TermGenie]
synonym: "inhibition of centromere-specific histone exchange" NARROW [GOC:TermGenie]
synonym: "inhibition of centromere-specific nucleosome assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of centromeric DNA replication-independent nucleosome assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA replication-independent nucleosome assembly at centromere" NARROW [GOC:TermGenie]
synonym: "negative regulation of CenH3-containing nucleosome assembly at centromere" RELATED [GOC:TermGenie]
synonym: "negative regulation of CENP-A deposition" RELATED [GOC:TermGenie]
synonym: "negative regulation of CENP-A loading" RELATED [GOC:TermGenie]
synonym: "negative regulation of centromere specific nucleosome exchange" RELATED [GOC:TermGenie]
synonym: "negative regulation of centromere-specific histone exchange" EXACT [GOC:TermGenie]
synonym: "negative regulation of centromere-specific nucleosome assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of centromeric DNA replication-independent nucleosome assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of DNA replication-independent nucleosome assembly at centromere" EXACT [GOC:TermGenie]
is_a: GO:0031333 ! negative regulation of protein complex assembly
is_a: GO:0045798 ! negative regulation of chromatin assembly or disassembly
is_a: GO:0051053 ! negative regulation of DNA metabolic process
is_a: GO:1900050 ! negative regulation of histone exchange
is_a: GO:1903097 ! regulation of CENP-A containing nucleosome assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034080 ! CENP-A containing nucleosome assembly
relationship: negatively_regulates GO:0034080 ! CENP-A containing nucleosome assembly
created_by: vw
creation_date: 2014-06-03T16:15:36Z

[Term]
id: GO:1903099
name: positive regulation of CENP-A containing nucleosome assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the formation of nucleosomes containing the histone H3 variant CENP-A to form centromeric chromatin. This specialised chromatin occurs at centromeric region in point centromeres,  and the central core in modular centromeres." [GO_REF:0000058, GOC:TermGenie, PMID:24710126]
synonym: "activation of CenH3-containing nucleosome assembly at centromere" RELATED [GOC:TermGenie]
synonym: "activation of CENP-A containing nucleosome assembly at centromere" NARROW [GOC:TermGenie]
synonym: "activation of CENP-A deposition" RELATED [GOC:TermGenie]
synonym: "activation of CENP-A loading" RELATED [GOC:TermGenie]
synonym: "activation of centromere specific nucleosome exchange" RELATED [GOC:TermGenie]
synonym: "activation of centromere-specific histone exchange" NARROW [GOC:TermGenie]
synonym: "activation of centromere-specific nucleosome assembly" NARROW [GOC:TermGenie]
synonym: "activation of centromeric DNA replication-independent nucleosome assembly" NARROW [GOC:TermGenie]
synonym: "activation of DNA replication-independent nucleosome assembly at centromere" NARROW [GOC:TermGenie]
synonym: "positive regulation of CenH3-containing nucleosome assembly at centromere" RELATED [GOC:TermGenie]
synonym: "positive regulation of CENP-A deposition" RELATED [GOC:TermGenie]
synonym: "positive regulation of CENP-A loading" RELATED [GOC:TermGenie]
synonym: "positive regulation of centromere specific nucleosome exchange" RELATED [GOC:TermGenie]
synonym: "positive regulation of centromere-specific histone exchange" EXACT [GOC:TermGenie]
synonym: "positive regulation of centromere-specific nucleosome assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of centromeric DNA replication-independent nucleosome assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of DNA replication-independent nucleosome assembly at centromere" EXACT [GOC:TermGenie]
synonym: "up regulation of CenH3-containing nucleosome assembly at centromere" RELATED [GOC:TermGenie]
synonym: "up regulation of CENP-A containing nucleosome assembly at centromere" EXACT [GOC:TermGenie]
synonym: "up regulation of CENP-A deposition" RELATED [GOC:TermGenie]
synonym: "up regulation of CENP-A loading" RELATED [GOC:TermGenie]
synonym: "up regulation of centromere specific nucleosome exchange" RELATED [GOC:TermGenie]
synonym: "up regulation of centromere-specific histone exchange" EXACT [GOC:TermGenie]
synonym: "up regulation of centromere-specific nucleosome assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of centromeric DNA replication-independent nucleosome assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA replication-independent nucleosome assembly at centromere" EXACT [GOC:TermGenie]
synonym: "up-regulation of CenH3-containing nucleosome assembly at centromere" RELATED [GOC:TermGenie]
synonym: "up-regulation of CENP-A containing nucleosome assembly at centromere" EXACT [GOC:TermGenie]
synonym: "up-regulation of CENP-A deposition" RELATED [GOC:TermGenie]
synonym: "up-regulation of CENP-A loading" RELATED [GOC:TermGenie]
synonym: "up-regulation of centromere specific nucleosome exchange" RELATED [GOC:TermGenie]
synonym: "up-regulation of centromere-specific histone exchange" EXACT [GOC:TermGenie]
synonym: "up-regulation of centromere-specific nucleosome assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of centromeric DNA replication-independent nucleosome assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA replication-independent nucleosome assembly at centromere" EXACT [GOC:TermGenie]
synonym: "upregulation of CenH3-containing nucleosome assembly at centromere" RELATED [GOC:TermGenie]
synonym: "upregulation of CENP-A containing nucleosome assembly at centromere" EXACT [GOC:TermGenie]
synonym: "upregulation of CENP-A deposition" RELATED [GOC:TermGenie]
synonym: "upregulation of CENP-A loading" RELATED [GOC:TermGenie]
synonym: "upregulation of centromere specific nucleosome exchange" RELATED [GOC:TermGenie]
synonym: "upregulation of centromere-specific histone exchange" EXACT [GOC:TermGenie]
synonym: "upregulation of centromere-specific nucleosome assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of centromeric DNA replication-independent nucleosome assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA replication-independent nucleosome assembly at centromere" EXACT [GOC:TermGenie]
is_a: GO:0031334 ! positive regulation of protein complex assembly
is_a: GO:0045799 ! positive regulation of chromatin assembly or disassembly
is_a: GO:0051054 ! positive regulation of DNA metabolic process
is_a: GO:1900051 ! positive regulation of histone exchange
is_a: GO:1903097 ! regulation of CENP-A containing nucleosome assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034080 ! CENP-A containing nucleosome assembly
relationship: positively_regulates GO:0034080 ! CENP-A containing nucleosome assembly
created_by: vw
creation_date: 2014-06-03T16:15:42Z

[Term]
id: GO:1903100
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate." [GO_REF:0000068, GOC:bhm, GOC:TermGenie, PMID:19037259]
synonym: "1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolism" EXACT [GOC:TermGenie]
is_a: GO:0046488 ! phosphatidylinositol metabolic process
created_by: bhm
creation_date: 2014-06-04T14:14:24Z

[Term]
id: GO:1903101
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate." [GO_REF:0000068, GOC:bhm, GOC:TermGenie, PMID:19037259]
synonym: "1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate breakdown" EXACT [GOC:TermGenie]
synonym: "1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate catabolism" EXACT [GOC:TermGenie]
synonym: "1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate degradation" EXACT [GOC:TermGenie]
is_a: GO:0031161 ! phosphatidylinositol catabolic process
is_a: GO:1903100 ! 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process
created_by: bhm
creation_date: 2014-06-04T14:14:30Z

[Term]
id: GO:1903102
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate." [GO_REF:0000068, GOC:bhm, GOC:TermGenie, PMID:19037259]
synonym: "1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate anabolism" EXACT [GOC:TermGenie]
synonym: "1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate biosynthesis" EXACT [GOC:TermGenie]
synonym: "1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate formation" EXACT [GOC:TermGenie]
synonym: "1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate synthesis" EXACT [GOC:TermGenie]
is_a: GO:0006661 ! phosphatidylinositol biosynthetic process
is_a: GO:1903100 ! 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process
created_by: bhm
creation_date: 2014-06-04T14:14:36Z

[Term]
id: GO:1903103
name: potassium:proton antiporter complex
namespace: cellular_component
def: "A protein complex which is capable of potassium:proton antiporter activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:21041667]
comment: An example of this is kefC in E. coli (P03819) in PMID:21041667 (inferred from direct assay).
is_a: GO:1902495 ! transmembrane transporter complex
created_by: bhm
creation_date: 2014-06-04T20:51:33Z

[Term]
id: GO:1903104
name: regulation of insulin receptor signaling pathway involved in determination of adult lifespan
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of insulin receptor signaling pathway involved in determination of adult lifespan." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:19853560]
synonym: "regulation of daf-2 receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie]
synonym: "regulation of insulin receptor signaling pathway of determination of adult lifespan" EXACT [GOC:TermGenie]
synonym: "regulation of insulin receptor signalling pathway of determination of adult lifespan" EXACT [GOC:TermGenie]
is_a: GO:0046626 ! regulation of insulin receptor signaling pathway
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1901047 ! insulin receptor signaling pathway involved in determination of adult lifespan
relationship: regulates GO:1901047 ! insulin receptor signaling pathway involved in determination of adult lifespan
created_by: kmv
creation_date: 2014-06-05T20:56:06Z

[Term]
id: GO:1903105
name: negative regulation of insulin receptor signaling pathway involved in determination of adult lifespan
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of insulin receptor signaling pathway involved in determination of adult lifespan." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:19853560]
synonym: "down regulation of daf-2 receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie]
synonym: "down regulation of insulin receptor signaling pathway involved in determination of adult lifespan" EXACT [GOC:TermGenie]
synonym: "down regulation of insulin receptor signaling pathway of determination of adult lifespan" EXACT [GOC:TermGenie]
synonym: "down regulation of insulin receptor signalling pathway of determination of adult lifespan" EXACT [GOC:TermGenie]
synonym: "down-regulation of daf-2 receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie]
synonym: "down-regulation of insulin receptor signaling pathway involved in determination of adult lifespan" EXACT [GOC:TermGenie]
synonym: "down-regulation of insulin receptor signaling pathway of determination of adult lifespan" EXACT [GOC:TermGenie]
synonym: "down-regulation of insulin receptor signalling pathway of determination of adult lifespan" EXACT [GOC:TermGenie]
synonym: "downregulation of daf-2 receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie]
synonym: "downregulation of insulin receptor signaling pathway involved in determination of adult lifespan" EXACT [GOC:TermGenie]
synonym: "downregulation of insulin receptor signaling pathway of determination of adult lifespan" EXACT [GOC:TermGenie]
synonym: "downregulation of insulin receptor signalling pathway of determination of adult lifespan" EXACT [GOC:TermGenie]
synonym: "inhibition of daf-2 receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie]
synonym: "inhibition of insulin receptor signaling pathway involved in determination of adult lifespan" NARROW [GOC:TermGenie]
synonym: "inhibition of insulin receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie]
synonym: "inhibition of insulin receptor signalling pathway of determination of adult lifespan" NARROW [GOC:TermGenie]
synonym: "negative regulation of daf-2 receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie]
synonym: "negative regulation of insulin receptor signaling pathway of determination of adult lifespan" EXACT [GOC:TermGenie]
synonym: "negative regulation of insulin receptor signalling pathway of determination of adult lifespan" EXACT [GOC:TermGenie]
is_a: GO:0046627 ! negative regulation of insulin receptor signaling pathway
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1903104 ! regulation of insulin receptor signaling pathway involved in determination of adult lifespan
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1901047 ! insulin receptor signaling pathway involved in determination of adult lifespan
relationship: negatively_regulates GO:1901047 ! insulin receptor signaling pathway involved in determination of adult lifespan
created_by: kmv
creation_date: 2014-06-05T20:56:12Z

[Term]
id: GO:1903106
name: positive regulation of insulin receptor signaling pathway involved in determination of adult lifespan
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of insulin receptor signaling pathway involved in determination of adult lifespan." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:19853560]
synonym: "activation of daf-2 receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie]
synonym: "activation of insulin receptor signaling pathway involved in determination of adult lifespan" NARROW [GOC:TermGenie]
synonym: "activation of insulin receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie]
synonym: "activation of insulin receptor signalling pathway of determination of adult lifespan" NARROW [GOC:TermGenie]
synonym: "positive regulation of daf-2 receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie]
synonym: "positive regulation of insulin receptor signaling pathway of determination of adult lifespan" EXACT [GOC:TermGenie]
synonym: "positive regulation of insulin receptor signalling pathway of determination of adult lifespan" EXACT [GOC:TermGenie]
synonym: "up regulation of daf-2 receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie]
synonym: "up regulation of insulin receptor signaling pathway involved in determination of adult lifespan" EXACT [GOC:TermGenie]
synonym: "up regulation of insulin receptor signaling pathway of determination of adult lifespan" EXACT [GOC:TermGenie]
synonym: "up regulation of insulin receptor signalling pathway of determination of adult lifespan" EXACT [GOC:TermGenie]
synonym: "up-regulation of daf-2 receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie]
synonym: "up-regulation of insulin receptor signaling pathway involved in determination of adult lifespan" EXACT [GOC:TermGenie]
synonym: "up-regulation of insulin receptor signaling pathway of determination of adult lifespan" EXACT [GOC:TermGenie]
synonym: "up-regulation of insulin receptor signalling pathway of determination of adult lifespan" EXACT [GOC:TermGenie]
synonym: "upregulation of daf-2 receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie]
synonym: "upregulation of insulin receptor signaling pathway involved in determination of adult lifespan" EXACT [GOC:TermGenie]
synonym: "upregulation of insulin receptor signaling pathway of determination of adult lifespan" EXACT [GOC:TermGenie]
synonym: "upregulation of insulin receptor signalling pathway of determination of adult lifespan" EXACT [GOC:TermGenie]
is_a: GO:0046628 ! positive regulation of insulin receptor signaling pathway
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1903104 ! regulation of insulin receptor signaling pathway involved in determination of adult lifespan
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1901047 ! insulin receptor signaling pathway involved in determination of adult lifespan
relationship: positively_regulates GO:1901047 ! insulin receptor signaling pathway involved in determination of adult lifespan
created_by: kmv
creation_date: 2014-06-05T20:56:19Z

[Term]
id: GO:1903107
name: insulin receptor signaling pathway involved in dauer larval development
namespace: biological_process
def: "Any insulin receptor signaling pathway that is involved in dauer larval development." [GO_REF:0000060, GOC:kmv, GOC:TermGenie, PMID:19853560]
synonym: "daf-2 receptor signaling pathway involved in dauer larval development" NARROW [GOC:TermGenie]
synonym: "insulin receptor signalling pathway involved in dauer larval development" EXACT [GOC:TermGenie]
is_a: GO:0008286 ! insulin receptor signaling pathway
intersection_of: GO:0008286 ! insulin receptor signaling pathway
intersection_of: part_of GO:0040024 ! dauer larval development
relationship: part_of GO:0040024 ! dauer larval development
created_by: kmv
creation_date: 2014-06-05T21:30:03Z

[Term]
id: GO:1903108
name: regulation of transcription from mitochondrial promoter
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from mitochondrial promoter." [GO_REF:0000058, GOC:TermGenie, PMID:21357609]
synonym: "regulation of mitochondrial transcription" EXACT [GOC:TermGenie]
is_a: GO:0006355 ! regulation of transcription, DNA-templated
is_a: GO:0010821 ! regulation of mitochondrion organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006390 ! transcription from mitochondrial promoter
relationship: regulates GO:0006390 ! transcription from mitochondrial promoter
created_by: al
creation_date: 2014-06-09T11:53:14Z

[Term]
id: GO:1903109
name: positive regulation of transcription from mitochondrial promoter
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transcription from mitochondrial promoter." [GO_REF:0000058, GOC:TermGenie, PMID:21357609]
synonym: "activation of mitochondrial transcription" NARROW [GOC:TermGenie]
synonym: "activation of transcription from mitochondrial promoter" NARROW [GOC:TermGenie]
synonym: "positive regulation of mitochondrial transcription" EXACT [GOC:TermGenie]
synonym: "up regulation of mitochondrial transcription" EXACT [GOC:TermGenie]
synonym: "up regulation of transcription from mitochondrial promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitochondrial transcription" EXACT [GOC:TermGenie]
synonym: "up-regulation of transcription from mitochondrial promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of mitochondrial transcription" EXACT [GOC:TermGenie]
synonym: "upregulation of transcription from mitochondrial promoter" EXACT [GOC:TermGenie]
is_a: GO:0010822 ! positive regulation of mitochondrion organization
is_a: GO:0045893 ! positive regulation of transcription, DNA-templated
is_a: GO:1903108 ! regulation of transcription from mitochondrial promoter
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006390 ! transcription from mitochondrial promoter
relationship: positively_regulates GO:0006390 ! transcription from mitochondrial promoter
created_by: al
creation_date: 2014-06-09T11:53:20Z

[Term]
id: GO:1903110
name: regulation of single-strand break repair via homologous recombination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of single-strand break repair via homologous recombination." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:24339919]
is_a: GO:0000018 ! regulation of DNA recombination
is_a: GO:1903516 ! regulation of single strand break repair
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990396 ! single-strand break repair via homologous recombination
relationship: regulates GO:1990396 ! single-strand break repair via homologous recombination
created_by: pr
creation_date: 2014-06-09T12:11:26Z

[Term]
id: GO:1903111
name: negative regulation of single-strand break repair via homologous recombination
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of single-strand break repair via homologous recombination." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:24339919]
synonym: "down regulation of single-strand break repair via homologous recombination" EXACT [GOC:TermGenie]
synonym: "down-regulation of single-strand break repair via homologous recombination" EXACT [GOC:TermGenie]
synonym: "downregulation of single-strand break repair via homologous recombination" EXACT [GOC:TermGenie]
synonym: "inhibition of single-strand break repair via homologous recombination" NARROW [GOC:TermGenie]
is_a: GO:0045910 ! negative regulation of DNA recombination
is_a: GO:1903110 ! regulation of single-strand break repair via homologous recombination
is_a: GO:1903517 ! negative regulation of single strand break repair
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990396 ! single-strand break repair via homologous recombination
relationship: negatively_regulates GO:1990396 ! single-strand break repair via homologous recombination
created_by: pr
creation_date: 2014-06-09T12:11:32Z

[Term]
id: GO:1903112
name: positive regulation of single-strand break repair via homologous recombination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of single-strand break repair via homologous recombination." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:24339919]
synonym: "activation of single-strand break repair via homologous recombination" NARROW [GOC:TermGenie]
synonym: "up regulation of single-strand break repair via homologous recombination" EXACT [GOC:TermGenie]
synonym: "up-regulation of single-strand break repair via homologous recombination" EXACT [GOC:TermGenie]
synonym: "upregulation of single-strand break repair via homologous recombination" EXACT [GOC:TermGenie]
is_a: GO:0045911 ! positive regulation of DNA recombination
is_a: GO:1903110 ! regulation of single-strand break repair via homologous recombination
is_a: GO:1903518 ! positive regulation of single strand break repair
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990396 ! single-strand break repair via homologous recombination
relationship: positively_regulates GO:1990396 ! single-strand break repair via homologous recombination
created_by: pr
creation_date: 2014-06-09T12:11:38Z

[Term]
id: GO:1903113
name: copper ion transmembrane transporter complex
namespace: cellular_component
def: "A protein complex which is capable of copper ion transmembrane transporter activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:23122209]
comment: An example of this is CusA in E. coli (UniProt symbol P38054) in PMID:23122209 (inferred from direct assay).
is_a: GO:1902495 ! transmembrane transporter complex
created_by: bhm
creation_date: 2014-06-10T09:54:48Z

[Term]
id: GO:1903114
name: silver ion transmembrane transporter complex
namespace: cellular_component
def: "A protein complex which is capable of silver ion transmembrane transporter activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:11283292]
comment: An example of this is CusA in E. coli (UniProt symbol P38054) in PMID:11283292 (inferred from direct assay).
is_a: GO:1902495 ! transmembrane transporter complex
created_by: bhm
creation_date: 2014-06-10T10:00:02Z

[Term]
id: GO:1903115
name: regulation of actin filament-based movement
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of actin filament-based movement." [GO_REF:0000058, GOC:TermGenie, PMID:24798735]
is_a: GO:0032970 ! regulation of actin filament-based process
is_a: GO:0051270 ! regulation of cellular component movement
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030048 ! actin filament-based movement
relationship: regulates GO:0030048 ! actin filament-based movement
created_by: al
creation_date: 2014-06-12T16:55:57Z

[Term]
id: GO:1903116
name: positive regulation of actin filament-based movement
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of actin filament-based movement." [GO_REF:0000058, GOC:TermGenie, PMID:24798735]
synonym: "activation of actin filament-based movement" NARROW [GOC:TermGenie]
synonym: "up regulation of actin filament-based movement" EXACT [GOC:TermGenie]
synonym: "up-regulation of actin filament-based movement" EXACT [GOC:TermGenie]
synonym: "upregulation of actin filament-based movement" EXACT [GOC:TermGenie]
is_a: GO:0051272 ! positive regulation of cellular component movement
is_a: GO:1903115 ! regulation of actin filament-based movement
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030048 ! actin filament-based movement
relationship: positively_regulates GO:0030048 ! actin filament-based movement
created_by: al
creation_date: 2014-06-12T16:56:04Z

[Term]
id: GO:1903117
name: regulation of actin filament organization involved in cytokinetic actomyosin contractile ring assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of actin filament organization involved in cytokinetic actomyosin contractile ring assembly." [GO_REF:0000058, GOC:TermGenie, PMID:24798735]
synonym: "regulation of actin filament organisation of constriction ring assembly" RELATED [GOC:TermGenie]
synonym: "regulation of actin filament organisation of contractile ring assembly" EXACT [GOC:TermGenie]
synonym: "regulation of actin filament organisation of cytokinesis, actomyosin contractile ring assembly" EXACT [GOC:TermGenie]
synonym: "regulation of actin filament organisation of cytokinesis, actomyosin contractile ring formation" RELATED [GOC:TermGenie]
synonym: "regulation of actin filament organisation of cytokinesis, actomyosin ring biosynthesis" RELATED [GOC:TermGenie]
synonym: "regulation of actin filament organisation of cytokinesis, actomyosin ring formation" RELATED [GOC:TermGenie]
synonym: "regulation of actin filament organisation of cytokinesis, contractile ring assembly" RELATED [GOC:TermGenie]
synonym: "regulation of actin filament organization of constriction ring assembly" RELATED [GOC:TermGenie]
synonym: "regulation of actin filament organization of contractile ring assembly" EXACT [GOC:TermGenie]
synonym: "regulation of actin filament organization of cytokinesis, actomyosin contractile ring assembly" EXACT [GOC:TermGenie]
synonym: "regulation of actin filament organization of cytokinesis, actomyosin contractile ring formation" RELATED [GOC:TermGenie]
synonym: "regulation of actin filament organization of cytokinesis, actomyosin ring biosynthesis" RELATED [GOC:TermGenie]
synonym: "regulation of actin filament organization of cytokinesis, actomyosin ring formation" RELATED [GOC:TermGenie]
synonym: "regulation of actin filament organization of cytokinesis, contractile ring assembly" RELATED [GOC:TermGenie]
synonym: "regulation of regulation of actin filament localization of constriction ring assembly" RELATED [GOC:TermGenie]
synonym: "regulation of regulation of actin filament localization of contractile ring assembly" RELATED [GOC:TermGenie]
synonym: "regulation of regulation of actin filament localization of cytokinesis, actomyosin contractile ring assembly" RELATED [GOC:TermGenie]
synonym: "regulation of regulation of actin filament localization of cytokinesis, actomyosin contractile ring formation" RELATED [GOC:TermGenie]
synonym: "regulation of regulation of actin filament localization of cytokinesis, actomyosin ring biosynthesis" RELATED [GOC:TermGenie]
synonym: "regulation of regulation of actin filament localization of cytokinesis, actomyosin ring formation" RELATED [GOC:TermGenie]
synonym: "regulation of regulation of actin filament localization of cytokinesis, contractile ring assembly" RELATED [GOC:TermGenie]
is_a: GO:2000431 ! regulation of cytokinesis, actomyosin contractile ring assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:2000689 ! actomyosin contractile ring assembly actin filament organization
relationship: regulates GO:2000689 ! actomyosin contractile ring assembly actin filament organization
created_by: al
creation_date: 2014-06-12T16:57:17Z

[Term]
id: GO:1903118
name: urate homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of urate within an organism or cell." [GO_REF:0000072, GOC:dph, GOC:TermGenie, PMID:22306318]
is_a: GO:0048878 ! chemical homeostasis
created_by: dph
creation_date: 2014-06-13T14:54:51Z

[Term]
id: GO:1903119
name: protein localization to actin cytoskeleton
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, the location of an actin cytoskeleton." [GO_REF:0000087, GOC:TermGenie, PMID:24798735]
synonym: "protein localisation in actin cytoskeleton" EXACT [GOC:TermGenie]
synonym: "protein localisation to actin cytoskeleton" EXACT [GOC:TermGenie]
synonym: "protein localization in actin cytoskeleton" EXACT [GOC:TermGenie]
is_a: GO:0044380 ! protein localization to cytoskeleton
created_by: mah
creation_date: 2014-06-16T11:27:09Z

[Term]
id: GO:1903120
name: protein localization to actin filament bundle
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, the location of an actin filament bundle." [GO_REF:0000087, GOC:TermGenie, PMID:24798735]
synonym: "protein localisation in actin filament bundle" EXACT [GOC:TermGenie]
synonym: "protein localisation to actin filament bundle" EXACT [GOC:TermGenie]
synonym: "protein localization in actin filament bundle" EXACT [GOC:TermGenie]
synonym: "protein localization to actin cable" RELATED [GOC:mah]
is_a: GO:1903119 ! protein localization to actin cytoskeleton
created_by: mah
creation_date: 2014-06-16T11:27:16Z

[Term]
id: GO:1903121
name: regulation of TRAIL-activated apoptotic signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of TRAIL-activated apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "regulation of TRAIL-activated extrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "regulation of TRAIL-induced apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "regulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:1902041 ! regulation of extrinsic apoptotic signaling pathway via death domain receptors
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0036462 ! TRAIL-activated apoptotic signaling pathway
relationship: regulates GO:0036462 ! TRAIL-activated apoptotic signaling pathway
created_by: bf
creation_date: 2014-06-17T12:39:15Z

[Term]
id: GO:1903122
name: negative regulation of TRAIL-activated apoptotic signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of TRAIL-activated apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21785459]
synonym: "down regulation of TRAIL-activated apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of TRAIL-activated extrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of TRAIL-induced apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of TRAIL-activated apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of TRAIL-activated extrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of TRAIL-induced apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of TRAIL-activated apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of TRAIL-activated extrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of TRAIL-induced apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of TRAIL-activated apoptotic signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of TRAIL-activated extrinsic apoptotic signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of TRAIL-induced apoptotic signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of TRAIL-activated extrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of TRAIL-induced apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:1902042 ! negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
is_a: GO:1903121 ! regulation of TRAIL-activated apoptotic signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0036462 ! TRAIL-activated apoptotic signaling pathway
relationship: negatively_regulates GO:0036462 ! TRAIL-activated apoptotic signaling pathway
created_by: bf
creation_date: 2014-06-17T12:39:21Z

[Term]
id: GO:1903123
name: regulation of thioredoxin peroxidase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of thioredoxin peroxidase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "regulation of thiol peroxidase activity" EXACT [GOC:TermGenie]
synonym: "regulation of TPx activity" EXACT [GOC:TermGenie]
synonym: "regulation of TrxPx activity" EXACT [GOC:TermGenie]
is_a: GO:2000468 ! regulation of peroxidase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008379 ! thioredoxin peroxidase activity
relationship: regulates GO:0008379 ! thioredoxin peroxidase activity
created_by: bf
creation_date: 2014-06-18T11:03:11Z

[Term]
id: GO:1903124
name: negative regulation of thioredoxin peroxidase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of thioredoxin peroxidase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21850687]
synonym: "down regulation of thiol peroxidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of thioredoxin peroxidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of TPx activity" EXACT [GOC:TermGenie]
synonym: "down regulation of TrxPx activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of thiol peroxidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of thioredoxin peroxidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of TPx activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of TrxPx activity" EXACT [GOC:TermGenie]
synonym: "downregulation of thiol peroxidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of thioredoxin peroxidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of TPx activity" EXACT [GOC:TermGenie]
synonym: "downregulation of TrxPx activity" EXACT [GOC:TermGenie]
synonym: "inhibition of thiol peroxidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of thioredoxin peroxidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of TPx activity" NARROW [GOC:TermGenie]
synonym: "inhibition of TrxPx activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of thiol peroxidase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of TPx activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of TrxPx activity" EXACT [GOC:TermGenie]
is_a: GO:1903123 ! regulation of thioredoxin peroxidase activity
is_a: GO:2000469 ! negative regulation of peroxidase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008379 ! thioredoxin peroxidase activity
relationship: negatively_regulates GO:0008379 ! thioredoxin peroxidase activity
created_by: bf
creation_date: 2014-06-18T11:03:26Z

[Term]
id: GO:1903125
name: negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation
namespace: biological_process
def: "A peptidyl-threonine phosphorylation that results in negative regulation of thioredoxin peroxidase activity." [GO_REF:0000063, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21850687]
synonym: "negative regulation of thiol peroxidase activity by peptidyl-threonine phosphorylation" EXACT [GOC:TermGenie]
synonym: "negative regulation of TPx activity by peptidyl-threonine phosphorylation" EXACT [GOC:TermGenie]
synonym: "negative regulation of TrxPx activity by peptidyl-threonine phosphorylation" EXACT [GOC:TermGenie]
is_a: GO:0018107 ! peptidyl-threonine phosphorylation
is_a: GO:1903124 ! negative regulation of thioredoxin peroxidase activity
intersection_of: GO:0018107 ! peptidyl-threonine phosphorylation
intersection_of: negatively_regulates GO:0008379 ! thioredoxin peroxidase activity
relationship: negatively_regulates GO:0008379 ! thioredoxin peroxidase activity
created_by: bf
creation_date: 2014-06-24T08:47:25Z

[Term]
id: GO:1903126
name: negative regulation of centriole-centriole cohesion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of centriole-centriole cohesion." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24554434]
synonym: "down regulation of centriole-centriole cohesion" EXACT [GOC:TermGenie]
synonym: "down-regulation of centriole-centriole cohesion" EXACT [GOC:TermGenie]
synonym: "downregulation of centriole-centriole cohesion" EXACT [GOC:TermGenie]
synonym: "inhibition of centriole-centriole cohesion" NARROW [GOC:TermGenie]
is_a: GO:0030997 ! regulation of centriole-centriole cohesion
is_a: GO:0051494 ! negative regulation of cytoskeleton organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010457 ! centriole-centriole cohesion
relationship: negatively_regulates GO:0010457 ! centriole-centriole cohesion
created_by: als
creation_date: 2014-06-24T09:31:45Z

[Term]
id: GO:1903127
name: positive regulation of centriole-centriole cohesion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of centriole-centriole cohesion." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24554434]
synonym: "activation of centriole-centriole cohesion" NARROW [GOC:TermGenie]
synonym: "up regulation of centriole-centriole cohesion" EXACT [GOC:TermGenie]
synonym: "up-regulation of centriole-centriole cohesion" EXACT [GOC:TermGenie]
synonym: "upregulation of centriole-centriole cohesion" EXACT [GOC:TermGenie]
is_a: GO:0030997 ! regulation of centriole-centriole cohesion
is_a: GO:0051495 ! positive regulation of cytoskeleton organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010457 ! centriole-centriole cohesion
relationship: positively_regulates GO:0010457 ! centriole-centriole cohesion
created_by: als
creation_date: 2014-06-24T09:31:51Z

[Term]
id: GO:1903128
name: regulation of leucine import into cell
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of leucine import into cell." [GO_REF:0000058, GOC:TermGenie, PMID:24876389]
synonym: "regulation of L-leucine import into cell" NARROW [GOC:TermGenie]
is_a: GO:0034765 ! regulation of ion transmembrane transport
is_a: GO:0060357 ! regulation of leucine import
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990122 ! leucine import into cell
relationship: regulates GO:1990122 ! leucine import into cell
created_by: vw
creation_date: 2014-06-25T13:09:51Z

[Term]
id: GO:1903129
name: negative regulation of leucine import into cell
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of leucine import into cell." [GO_REF:0000058, GOC:TermGenie, PMID:24876389]
synonym: "down regulation of L-leucine import into cell" NARROW [GOC:TermGenie]
synonym: "down regulation of leucine import into cell" EXACT [GOC:TermGenie]
synonym: "down-regulation of L-leucine import into cell" NARROW [GOC:TermGenie]
synonym: "down-regulation of leucine import into cell" EXACT [GOC:TermGenie]
synonym: "downregulation of L-leucine import into cell" NARROW [GOC:TermGenie]
synonym: "downregulation of leucine import into cell" EXACT [GOC:TermGenie]
synonym: "inhibition of L-leucine import into cell" NARROW [GOC:TermGenie]
synonym: "inhibition of leucine import into cell" NARROW [GOC:TermGenie]
synonym: "negative regulation of L-leucine import into cell" NARROW [GOC:TermGenie]
is_a: GO:0034766 ! negative regulation of ion transmembrane transport
is_a: GO:0060358 ! negative regulation of leucine import
is_a: GO:1903128 ! regulation of leucine import into cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990122 ! leucine import into cell
relationship: negatively_regulates GO:1990122 ! leucine import into cell
created_by: vw
creation_date: 2014-06-25T13:09:58Z

[Term]
id: GO:1903130
name: positive regulation of leucine import into cell
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of leucine import into cell." [GO_REF:0000058, GOC:TermGenie, PMID:24876389]
synonym: "activation of L-leucine import into cell" NARROW [GOC:TermGenie]
synonym: "activation of leucine import into cell" NARROW [GOC:TermGenie]
synonym: "positive regulation of L-leucine import into cell" NARROW [GOC:TermGenie]
synonym: "up regulation of L-leucine import into cell" NARROW [GOC:TermGenie]
synonym: "up regulation of leucine import into cell" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-leucine import into cell" NARROW [GOC:TermGenie]
synonym: "up-regulation of leucine import into cell" EXACT [GOC:TermGenie]
synonym: "upregulation of L-leucine import into cell" NARROW [GOC:TermGenie]
synonym: "upregulation of leucine import into cell" EXACT [GOC:TermGenie]
is_a: GO:0034767 ! positive regulation of ion transmembrane transport
is_a: GO:0051957 ! positive regulation of amino acid transport
is_a: GO:1903128 ! regulation of leucine import into cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990122 ! leucine import into cell
relationship: positively_regulates GO:1990122 ! leucine import into cell
created_by: vw
creation_date: 2014-06-25T13:10:04Z

[Term]
id: GO:1903131
name: mononuclear cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a mononuclear cell." [CL:0000842, GO_REF:0000086, GOC:TermGenie, PMID:24759906]
is_a: GO:0002521 ! leukocyte differentiation
created_by: cynthia.smith
creation_date: 2014-06-25T15:47:09Z

[Term]
id: GO:1903132
name: regulation of tube lumen cavitation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tube lumen cavitation." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:22898778]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060605 ! tube lumen cavitation
relationship: regulates GO:0060605 ! tube lumen cavitation
created_by: dph
creation_date: 2014-06-25T20:18:58Z

[Term]
id: GO:1903133
name: negative regulation of tube lumen cavitation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tube lumen cavitation." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:22898778]
synonym: "inhibition of tube lumen cavitation" NARROW [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1903132 ! regulation of tube lumen cavitation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060605 ! tube lumen cavitation
relationship: negatively_regulates GO:0060605 ! tube lumen cavitation
created_by: dph
creation_date: 2014-06-25T20:19:04Z

[Term]
id: GO:1903134
name: trehalose catabolic process involved in cellular response to stress
namespace: biological_process
def: "Any trehalose catabolic process that is involved in cellular response to stress." [GO_REF:0000060, GOC:TermGenie, PMID:15965643]
synonym: "mycose catabolic process involved in cellular response to stress" EXACT [GOC:TermGenie]
synonym: "mycose catabolism involved in cellular response to stress" EXACT [GOC:TermGenie]
synonym: "mykose catabolic process involved in cellular response to stress" EXACT [GOC:TermGenie]
synonym: "mykose catabolism involved in cellular response to stress" EXACT [GOC:TermGenie]
synonym: "trehalose breakdown involved in cellular response to stress" EXACT [GOC:TermGenie]
synonym: "trehalose catabolism involved in cellular response to stress" EXACT [GOC:TermGenie]
synonym: "trehalose degradation involved in cellular response to stress" EXACT [GOC:TermGenie]
is_a: GO:0005993 ! trehalose catabolic process
is_a: GO:0070413 ! trehalose metabolism in response to stress
intersection_of: GO:0005993 ! trehalose catabolic process
intersection_of: part_of GO:0033554 ! cellular response to stress
relationship: part_of GO:0010353 ! response to trehalose
relationship: part_of GO:0033554 ! cellular response to stress
created_by: al
creation_date: 2014-06-25T22:28:34Z

[Term]
id: GO:1903135
name: cupric ion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with cupric ion, copper(2+)." [GO_REF:0000067, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24567322]
synonym: "copper(2+)binding" EXACT [CHEBI:29036]
synonym: "Cu(2+) binding" EXACT [CHEBI:29036]
synonym: "Cu(II) binding" EXACT [PMID:24567322]
is_a: GO:0005507 ! copper ion binding
created_by: bf
creation_date: 2014-06-26T14:38:16Z

[Term]
id: GO:1903136
name: cuprous ion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with cuprous ion, copper(1+)." [GO_REF:0000067, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24567322]
synonym: "copper(1+) binding" EXACT [CHEBI:49552]
synonym: "Cu(+) binding" EXACT [CHEBI:49552]
synonym: "Cu(I) binding" EXACT [PMID:24567322]
is_a: GO:0005507 ! copper ion binding
created_by: bf
creation_date: 2014-06-26T14:38:23Z

[Term]
id: GO:1903137
name: regulation of MAPK cascade involved in cell wall organization or biogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of MAPK cascade involved in cell wall organization or biogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:23934882]
synonym: "regulation of cell integrity MAPK pathway" EXACT [GOC:TermGenie]
synonym: "regulation of cell wall biogenesis, MAPKKK cascade" EXACT [GOC:TermGenie]
synonym: "regulation of MAPK cascade involved in cell wall biogenesis" NARROW [GOC:TermGenie]
synonym: "regulation of MAPKKK cascade involved in cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of Mpk1 cascade" NARROW [GOC:TermGenie]
synonym: "regulation of Pmk1 MAPK cell integrity signaling" NARROW [GOC:TermGenie]
synonym: "regulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway" NARROW [GOC:TermGenie]
synonym: "regulation of PMK1-MAPK signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "regulation of Slt2 cascade" NARROW [GOC:TermGenie]
is_a: GO:0043408 ! regulation of MAPK cascade
is_a: GO:1903338 ! regulation of cell wall organization or biogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000196 ! MAPK cascade involved in cell wall organization or biogenesis
relationship: regulates GO:0000196 ! MAPK cascade involved in cell wall organization or biogenesis
created_by: mah
creation_date: 2014-07-01T10:21:53Z

[Term]
id: GO:1903138
name: negative regulation of MAPK cascade involved in cell wall organization or biogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of MAPK cascade involved in cell wall organization or biogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:23934882]
synonym: "down regulation of cell integrity MAPK pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of cell wall biogenesis, MAPKKK cascade" EXACT [GOC:TermGenie]
synonym: "down regulation of MAPK cascade involved in cell wall biogenesis" NARROW [GOC:TermGenie]
synonym: "down regulation of MAPK cascade involved in cell wall organization or biogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of MAPKKK cascade involved in cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of Mpk1 cascade" NARROW [GOC:TermGenie]
synonym: "down regulation of Pmk1 MAPK cell integrity signaling" NARROW [GOC:TermGenie]
synonym: "down regulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway" NARROW [GOC:TermGenie]
synonym: "down regulation of PMK1-MAPK signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "down regulation of Slt2 cascade" NARROW [GOC:TermGenie]
synonym: "down-regulation of cell integrity MAPK pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell wall biogenesis, MAPKKK cascade" EXACT [GOC:TermGenie]
synonym: "down-regulation of MAPK cascade involved in cell wall biogenesis" NARROW [GOC:TermGenie]
synonym: "down-regulation of MAPK cascade involved in cell wall organization or biogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of MAPKKK cascade involved in cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of Mpk1 cascade" NARROW [GOC:TermGenie]
synonym: "down-regulation of Pmk1 MAPK cell integrity signaling" NARROW [GOC:TermGenie]
synonym: "down-regulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway" NARROW [GOC:TermGenie]
synonym: "down-regulation of PMK1-MAPK signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "down-regulation of Slt2 cascade" NARROW [GOC:TermGenie]
synonym: "downregulation of cell integrity MAPK pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of cell wall biogenesis, MAPKKK cascade" EXACT [GOC:TermGenie]
synonym: "downregulation of MAPK cascade involved in cell wall biogenesis" NARROW [GOC:TermGenie]
synonym: "downregulation of MAPK cascade involved in cell wall organization or biogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of MAPKKK cascade involved in cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of Mpk1 cascade" NARROW [GOC:TermGenie]
synonym: "downregulation of Pmk1 MAPK cell integrity signaling" NARROW [GOC:TermGenie]
synonym: "downregulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway" NARROW [GOC:TermGenie]
synonym: "downregulation of PMK1-MAPK signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "downregulation of Slt2 cascade" NARROW [GOC:TermGenie]
synonym: "inhibition of cell integrity MAPK pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of cell wall biogenesis, MAPKKK cascade" NARROW [GOC:TermGenie]
synonym: "inhibition of MAPK cascade involved in cell wall biogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of MAPK cascade involved in cell wall organization or biogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of MAPKKK cascade involved in cell wall biogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of Mpk1 cascade" NARROW [GOC:TermGenie]
synonym: "inhibition of Pmk1 MAPK cell integrity signaling" NARROW [GOC:TermGenie]
synonym: "inhibition of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of PMK1-MAPK signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of Slt2 cascade" NARROW [GOC:TermGenie]
synonym: "negative regulation of cell integrity MAPK pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of cell wall biogenesis, MAPKKK cascade" EXACT [GOC:TermGenie]
synonym: "negative regulation of MAPK cascade involved in cell wall biogenesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of MAPKKK cascade involved in cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of Mpk1 cascade" NARROW [GOC:TermGenie]
synonym: "negative regulation of Pmk1 MAPK cell integrity signaling" NARROW [GOC:TermGenie]
synonym: "negative regulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of PMK1-MAPK signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of Slt2 cascade" NARROW [GOC:TermGenie]
is_a: GO:0043409 ! negative regulation of MAPK cascade
is_a: GO:1903137 ! regulation of MAPK cascade involved in cell wall organization or biogenesis
is_a: GO:1903339 ! negative regulation of cell wall organization or biogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000196 ! MAPK cascade involved in cell wall organization or biogenesis
relationship: negatively_regulates GO:0000196 ! MAPK cascade involved in cell wall organization or biogenesis
created_by: mah
creation_date: 2014-07-01T10:21:59Z

[Term]
id: GO:1903139
name: positive regulation of MAPK cascade involved in cell wall organization or biogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of MAPK cascade involved in cell wall organization or biogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:23934882]
synonym: "activation of cell integrity MAPK pathway" NARROW [GOC:TermGenie]
synonym: "activation of cell wall biogenesis, MAPKKK cascade" NARROW [GOC:TermGenie]
synonym: "activation of MAPK cascade involved in cell wall biogenesis" NARROW [GOC:TermGenie]
synonym: "activation of MAPK cascade involved in cell wall organization or biogenesis" NARROW [GOC:TermGenie]
synonym: "activation of MAPKKK cascade involved in cell wall biogenesis" NARROW [GOC:TermGenie]
synonym: "activation of Mpk1 cascade" NARROW [GOC:TermGenie]
synonym: "activation of Pmk1 MAPK cell integrity signaling" NARROW [GOC:TermGenie]
synonym: "activation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway" NARROW [GOC:TermGenie]
synonym: "activation of PMK1-MAPK signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "activation of Slt2 cascade" NARROW [GOC:TermGenie]
synonym: "positive regulation of cell integrity MAPK pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of cell wall biogenesis, MAPKKK cascade" EXACT [GOC:TermGenie]
synonym: "positive regulation of MAPK cascade involved in cell wall biogenesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of MAPKKK cascade involved in cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of Mpk1 cascade" NARROW [GOC:TermGenie]
synonym: "positive regulation of Pmk1 MAPK cell integrity signaling" NARROW [GOC:TermGenie]
synonym: "positive regulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of PMK1-MAPK signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of Slt2 cascade" NARROW [GOC:TermGenie]
synonym: "up regulation of cell integrity MAPK pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of cell wall biogenesis, MAPKKK cascade" EXACT [GOC:TermGenie]
synonym: "up regulation of MAPK cascade involved in cell wall biogenesis" NARROW [GOC:TermGenie]
synonym: "up regulation of MAPK cascade involved in cell wall organization or biogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of MAPKKK cascade involved in cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of Mpk1 cascade" NARROW [GOC:TermGenie]
synonym: "up regulation of Pmk1 MAPK cell integrity signaling" NARROW [GOC:TermGenie]
synonym: "up regulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway" NARROW [GOC:TermGenie]
synonym: "up regulation of PMK1-MAPK signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "up regulation of Slt2 cascade" NARROW [GOC:TermGenie]
synonym: "up-regulation of cell integrity MAPK pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell wall biogenesis, MAPKKK cascade" EXACT [GOC:TermGenie]
synonym: "up-regulation of MAPK cascade involved in cell wall biogenesis" NARROW [GOC:TermGenie]
synonym: "up-regulation of MAPK cascade involved in cell wall organization or biogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of MAPKKK cascade involved in cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of Mpk1 cascade" NARROW [GOC:TermGenie]
synonym: "up-regulation of Pmk1 MAPK cell integrity signaling" NARROW [GOC:TermGenie]
synonym: "up-regulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway" NARROW [GOC:TermGenie]
synonym: "up-regulation of PMK1-MAPK signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "up-regulation of Slt2 cascade" NARROW [GOC:TermGenie]
synonym: "upregulation of cell integrity MAPK pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of cell wall biogenesis, MAPKKK cascade" EXACT [GOC:TermGenie]
synonym: "upregulation of MAPK cascade involved in cell wall biogenesis" NARROW [GOC:TermGenie]
synonym: "upregulation of MAPK cascade involved in cell wall organization or biogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of MAPKKK cascade involved in cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of Mpk1 cascade" NARROW [GOC:TermGenie]
synonym: "upregulation of Pmk1 MAPK cell integrity signaling" NARROW [GOC:TermGenie]
synonym: "upregulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway" NARROW [GOC:TermGenie]
synonym: "upregulation of PMK1-MAPK signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "upregulation of Slt2 cascade" NARROW [GOC:TermGenie]
is_a: GO:0043410 ! positive regulation of MAPK cascade
is_a: GO:1903137 ! regulation of MAPK cascade involved in cell wall organization or biogenesis
is_a: GO:1903340 ! positive regulation of cell wall organization or biogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000196 ! MAPK cascade involved in cell wall organization or biogenesis
relationship: positively_regulates GO:0000196 ! MAPK cascade involved in cell wall organization or biogenesis
created_by: mah
creation_date: 2014-07-01T10:22:05Z

[Term]
id: GO:1903140
name: regulation of establishment of endothelial barrier
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of establishment of endothelial barrier." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24851274]
is_a: GO:1901550 ! regulation of endothelial cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061028 ! establishment of endothelial barrier
relationship: regulates GO:0061028 ! establishment of endothelial barrier
created_by: als
creation_date: 2014-07-01T12:12:34Z

[Term]
id: GO:1903141
name: negative regulation of establishment of endothelial barrier
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of endothelial barrier." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24851274]
synonym: "down regulation of establishment of endothelial barrier" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of endothelial barrier" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of endothelial barrier" EXACT [GOC:TermGenie]
synonym: "inhibition of establishment of endothelial barrier" NARROW [GOC:TermGenie]
is_a: GO:1901551 ! negative regulation of endothelial cell development
is_a: GO:1903140 ! regulation of establishment of endothelial barrier
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061028 ! establishment of endothelial barrier
relationship: negatively_regulates GO:0061028 ! establishment of endothelial barrier
created_by: als
creation_date: 2014-07-01T12:12:40Z

[Term]
id: GO:1903142
name: positive regulation of establishment of endothelial barrier
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment of endothelial barrier." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24851274]
synonym: "activation of establishment of endothelial barrier" NARROW [GOC:TermGenie]
synonym: "up regulation of establishment of endothelial barrier" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of endothelial barrier" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of endothelial barrier" EXACT [GOC:TermGenie]
is_a: GO:1901552 ! positive regulation of endothelial cell development
is_a: GO:1903140 ! regulation of establishment of endothelial barrier
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061028 ! establishment of endothelial barrier
relationship: positively_regulates GO:0061028 ! establishment of endothelial barrier
created_by: als
creation_date: 2014-07-01T12:12:52Z

[Term]
id: GO:1903143
name: adrenomedullin receptor complex
namespace: cellular_component
def: "A transmembrane, G-protein-coupled signalling receptor complex which is capable of adrenomedullin receptor activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:22102369]
comment: An example of this is RAMP2 in human (O60895) in PMID:22102369 (inferred from direct assay).
synonym: "adrenomedullin receptor AM1 complex" NARROW []
synonym: "adrenomedullin receptor AM2 complex" NARROW []
is_a: GO:0038037 ! G-protein coupled receptor dimeric complex
is_a: GO:1903439 ! calcitonin family receptor complex
created_by: bhm
creation_date: 2014-07-02T08:56:47Z

[Term]
id: GO:1903144
name: actomyosin contractile ring actin filament
namespace: cellular_component
def: "Any actin filament that is part of a actomyosin contractile ring." [GO_REF:0000064, GOC:TermGenie, PMID:20807799, PMID:24954052]
synonym: "actin filament of actomyosin contractile ring" EXACT [GOC:TermGenie]
synonym: "actin filament of actomyosin ring" EXACT [GOC:TermGenie]
synonym: "actin filament of CAR" EXACT [GOC:TermGenie]
synonym: "actin filament of contractile actomyosin ring" EXACT [GOC:TermGenie]
synonym: "actin filament of cytokinetic ring" EXACT [GOC:TermGenie]
is_a: GO:0005884 ! actin filament
is_a: GO:0032155 ! cell division site part
is_a: GO:0044448 ! cell cortex part
intersection_of: GO:0005884 ! actin filament
intersection_of: part_of GO:0005826 ! actomyosin contractile ring
relationship: part_of GO:0005826 ! actomyosin contractile ring
created_by: vw
creation_date: 2014-07-06T16:20:05Z

[Term]
id: GO:1903145
name: actin filament of cell cortex of cell tip
namespace: cellular_component
def: "Any actin filament that is part of a cell cortex of cell tip." [GO_REF:0000064, GOC:TermGenie, PMID:20807799, PMID:24954052]
synonym: "actin filament of cell cortex of cell end" EXACT [GOC:TermGenie]
synonym: "microfilament of cell cortex of cell end" EXACT [GOC:TermGenie]
synonym: "microfilament of cell cortex of cell tip" EXACT [GOC:TermGenie]
is_a: GO:0005884 ! actin filament
is_a: GO:0044448 ! cell cortex part
intersection_of: GO:0005884 ! actin filament
intersection_of: part_of GO:0051285 ! cell cortex of cell tip
relationship: part_of GO:0051285 ! cell cortex of cell tip
created_by: vw
creation_date: 2014-07-06T16:24:01Z

[Term]
id: GO:1903146
name: regulation of mitophagy
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitochondrion degradation (mitophagy)." [GO_REF:0000058, GOC:autophagy, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24600391]
synonym: "regulation of mitochondrion degradation" BROAD [GOC:TermGenie]
is_a: GO:0010821 ! regulation of mitochondrion organization
is_a: GO:0016241 ! regulation of macroautophagy
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000422 ! mitophagy
relationship: regulates GO:0000422 ! mitophagy
created_by: bf
creation_date: 2014-07-09T08:23:51Z

[Term]
id: GO:1903147
name: negative regulation of mitophagy
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrion degradation (mitophagy)." [GO_REF:0000058, GOC:autophagy, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24600391]
synonym: "down regulation of mitochondrial degradation" BROAD [GOC:TermGenie]
synonym: "down regulation of mitochondrion degradation" BROAD [GOC:TermGenie]
synonym: "down-regulation of mitochondrion degradation" BROAD [GOC:TermGenie]
synonym: "down-regulation of mitophagy" BROAD [GOC:TermGenie]
synonym: "downregulation of mitochondrion degradation" BROAD [GOC:TermGenie]
synonym: "downregulation of mitophagy" EXACT [GOC:TermGenie]
synonym: "inhibition of mitochondrion degradation" RELATED [GOC:TermGenie]
synonym: "inhibition of mitophagy" NARROW [GOC:TermGenie]
synonym: "negative regulation of mitophagy" EXACT [GOC:TermGenie]
is_a: GO:0010823 ! negative regulation of mitochondrion organization
is_a: GO:0016242 ! negative regulation of macroautophagy
is_a: GO:1903146 ! regulation of mitophagy
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000422 ! mitophagy
relationship: negatively_regulates GO:0000422 ! mitophagy
created_by: bf
creation_date: 2014-07-09T08:23:58Z

[Term]
id: GO:1903148
name: obsolete uracil transmembrane transporter activity involved in uracil import into cell
namespace: molecular_function
def: "OBSOLETE. Any uracil transmembrane transporter activity that is involved in uracil import into cell." [GO_REF:0000061, GOC:dos, GOC:TermGenie, ISBN:0-8249-3695-6]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "uracil transmembrane transporter activity involved in uracil import into cell" EXACT []
synonym: "uracil/uridine permease activity involved in uracil import into cell" RELATED [GOC:TermGenie]
is_obsolete: true
created_by: dos
creation_date: 2014-07-09T11:55:24Z

[Term]
id: GO:1903149
name: obsolete adenine transmembrane transporter activity involved in adenine import into cell
namespace: molecular_function
def: "OBSOLETE. Any adenine transmembrane transporter activity that is involved in adenine import into cell." [GO_REF:0000061, GOC:dos, GOC:TermGenie, ISBN:0-8249-3695-6]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "adenine transmembrane transporter activity involved in adenine import into cell" EXACT []
is_obsolete: true
created_by: dos
creation_date: 2014-07-09T11:55:30Z

[Term]
id: GO:1903150
name: obsolete calcium ion transmembrane transporter activity involved in calcium ion import into cell
namespace: molecular_function
def: "OBSOLETE. Any calcium ion transmembrane transporter activity that is involved in calcium ion import into cell." [GO_REF:0000061, GOC:dos, GOC:TermGenie, ISBN:0-8249-3695-6]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "calcium ion transmembrane transporter activity involved in calcium ion import into cell" EXACT []
synonym: "calcium ion transmembrane transporter activity involved in calcium ion uptake into cell" EXACT [GOC:TermGenie]
is_obsolete: true
created_by: dos
creation_date: 2014-07-09T11:55:36Z

[Term]
id: GO:1903151
name: obsolete carbohydrate transmembrane transporter activity involved in carbohydrate import into cell
namespace: molecular_function
def: "OBSOLETE. Any carbohydrate transmembrane transporter activity that is involved in carbohydrate import into cell." [GO_REF:0000061, GOC:dos, GOC:TermGenie, ISBN:0-8249-3695-6]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "carbohydrate transmembrane transporter activity involved in carbohydrate import into cell" EXACT []
synonym: "sugar transporter involved in carbohydrate import into cell" NARROW [GOC:TermGenie]
is_obsolete: true
created_by: dos
creation_date: 2014-07-09T11:55:42Z

[Term]
id: GO:1903152
name: obsolete copper ion transmembrane transporter activity involved in copper ion import into cell
namespace: molecular_function
def: "OBSOLETE. Any copper ion transmembrane transporter activity that is involved in copper ion import into cell." [GO_REF:0000061, GOC:dos, GOC:TermGenie, ISBN:0-8249-3695-6]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "copper ion transmembrane transporter activity involved in copper cation import into cell" EXACT [GOC:TermGenie]
synonym: "copper ion transmembrane transporter activity involved in copper ion import into cell" EXACT []
synonym: "intracellular copper ion transporter involved in copper cation import into cell" NARROW [GOC:TermGenie]
synonym: "intracellular copper ion transporter involved in copper ion import into cell" NARROW [GOC:TermGenie]
synonym: "plasma membrane copper transporter involved in copper cation import into cell" NARROW [GOC:TermGenie]
synonym: "plasma membrane copper transporter involved in copper ion import into cell" NARROW [GOC:TermGenie]
is_obsolete: true
created_by: dos
creation_date: 2014-07-09T11:55:47Z

[Term]
id: GO:1903153
name: obsolete ferrous iron transmembrane transporter activity involved in ferrous iron import into cell
namespace: molecular_function
def: "OBSOLETE. Any ferrous iron transmembrane transporter activity that is involved in ferrous iron import into cell." [GO_REF:0000061, GOC:dos, GOC:TermGenie, ISBN:0-8249-3695-6]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "ferrous iron transmembrane transporter activity involved in ferrous ion import into cell" EXACT [GOC:TermGenie]
synonym: "ferrous iron transmembrane transporter activity involved in ferrous iron import into cell" EXACT []
is_obsolete: true
created_by: dos
creation_date: 2014-07-09T11:55:53Z

[Term]
id: GO:1903154
name: obsolete glucose transmembrane transporter activity involved in glucose import into cell
namespace: molecular_function
def: "OBSOLETE. Any glucose transmembrane transporter activity that is involved in glucose import into cell." [GO_REF:0000061, GOC:dos, GOC:TermGenie, ISBN:0-8249-3695-6]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "galactose/glucose (methylgalactoside) porter activity involved in glucose import into cell" RELATED [GOC:TermGenie]
synonym: "glucose permease activity involved in glucose import into cell" EXACT [GOC:TermGenie]
synonym: "glucose transmembrane transporter activity involved in glucose import into cell" EXACT []
synonym: "lactose/glucose efflux transporter activity involved in glucose import into cell" NARROW [GOC:TermGenie]
is_obsolete: true
created_by: dos
creation_date: 2014-07-09T11:55:59Z

[Term]
id: GO:1903155
name: obsolete glutathione transmembrane transporter activity involved in glutathione import into cell
namespace: molecular_function
def: "OBSOLETE. Any glutathione transmembrane transporter activity that is involved in glutathione import into cell." [GO_REF:0000061, GOC:dos, GOC:TermGenie, ISBN:0-8249-3695-6]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "glutathione transmembrane transporter activity involved in glutathione import into cell" EXACT []
synonym: "glutathione transmembrane transporter activity involved in glutathione uptake" EXACT [GOC:TermGenie]
is_obsolete: true
created_by: dos
creation_date: 2014-07-09T11:56:05Z

[Term]
id: GO:1903156
name: obsolete guanine transmembrane transporter activity involved in guanine import into cell
namespace: molecular_function
def: "OBSOLETE. Any guanine transmembrane transporter activity that is involved in guanine import into cell." [GO_REF:0000061, GOC:dos, GOC:TermGenie, ISBN:0-8249-3695-6]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "guanine transmembrane transporter activity involved in guanine import into cell" EXACT []
is_obsolete: true
created_by: dos
creation_date: 2014-07-09T11:56:10Z

[Term]
id: GO:1903157
name: obsolete iron ion transmembrane transporter activity involved in iron ion import into cell
namespace: molecular_function
def: "OBSOLETE. Any iron ion transmembrane transporter activity that is involved in iron ion import into cell." [GO_REF:0000061, GOC:dos, GOC:TermGenie, ISBN:0-8249-3695-6]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "iron ion transmembrane transporter activity involved in iron import into cell" RELATED [GOC:TermGenie]
synonym: "iron ion transmembrane transporter activity involved in iron ion import into cell" EXACT []
synonym: "iron transporter activity involved in iron import into cell" RELATED [GOC:TermGenie]
synonym: "iron transporter activity involved in iron ion import into cell" EXACT [GOC:TermGenie]
synonym: "multicopper ferroxidase iron transport mediator activity involved in iron import into cell" RELATED [GOC:TermGenie]
synonym: "multicopper ferroxidase iron transport mediator activity involved in iron ion import into cell" RELATED [GOC:TermGenie]
synonym: "transmembrane iron ion permease activity involved in iron import into cell" RELATED [GOC:TermGenie]
synonym: "transmembrane iron ion permease activity involved in iron ion import into cell" EXACT [GOC:TermGenie]
synonym: "transmembrane iron permease activity involved in iron import into cell" RELATED [GOC:TermGenie]
synonym: "transmembrane iron permease activity involved in iron ion import into cell" EXACT [GOC:TermGenie]
synonym: "zinc, iron permease activity involved in iron import into cell" RELATED [GOC:TermGenie]
synonym: "zinc, iron permease activity involved in iron ion import into cell" RELATED [GOC:TermGenie]
is_obsolete: true
created_by: dos
creation_date: 2014-07-09T11:56:16Z

[Term]
id: GO:1903158
name: obsolete L-glutamate transmembrane transporter activity involved in L-glutamate import into cell
namespace: molecular_function
def: "OBSOLETE. Any L-glutamate transmembrane transporter activity that is involved in L-glutamate import into cell." [GO_REF:0000061, GOC:dos, GOC:TermGenie, ISBN:0-8249-3695-6]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "glutamate/aspartate porter activity involved in L-glutamate import into cell" NARROW [GOC:TermGenie]
synonym: "glutamate/aspartate:sodium symporter activity involved in L-glutamate import into cell" NARROW [GOC:TermGenie]
synonym: "L-glutamate transmembrane transporter activity involved in L-glutamate import into cell" EXACT []
is_obsolete: true
created_by: dos
creation_date: 2014-07-09T11:56:21Z

[Term]
id: GO:1903159
name: obsolete malate transmembrane transporter activity involved in malate import into cell
namespace: molecular_function
def: "OBSOLETE. Any malate transmembrane transporter activity that is involved in malate import into cell." [GO_REF:0000061, GOC:dos, GOC:TermGenie, ISBN:0-8249-3695-6]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity involved in malate import into cell" RELATED [GOC:TermGenie]
synonym: "malate transmembrane transporter activity involved in malate import into cell" EXACT []
is_obsolete: true
created_by: dos
creation_date: 2014-07-09T11:56:27Z

[Term]
id: GO:1903160
name: obsolete nickel cation transmembrane transporter activity involved in nickel cation import into cell
namespace: molecular_function
def: "OBSOLETE. Any nickel cation transmembrane transporter activity that is involved in nickel cation import into cell." [GO_REF:0000061, GOC:dos, GOC:TermGenie, ISBN:0-8249-3695-6]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "nickel cation transmembrane transporter activity involved in nickel cation import into cell" EXACT []
synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity involved in nickel cation import into cell" RELATED [GOC:TermGenie]
is_obsolete: true
created_by: dos
creation_date: 2014-07-09T11:56:33Z

[Term]
id: GO:1903161
name: obsolete pantothenate transmembrane transporter activity involved in pantothenate import into cell
namespace: molecular_function
def: "OBSOLETE. Any pantothenate transmembrane transporter activity that is involved in pantothenate import into cell." [GO_REF:0000061, GOC:TermGenie, ISBN:0-8249-3695-6]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "pantothenate transmembrane transporter activity involved in pantothenate import into cell" EXACT []
synonym: "vitamin B5 transmembrane transporter activity involved in pantothenate import into cell" EXACT [GOC:TermGenie]
is_obsolete: true
created_by: dos
creation_date: 2014-07-09T11:56:38Z

[Term]
id: GO:1903162
name: obsolete serine transmembrane transporter activity involved in serine import into cell
namespace: molecular_function
def: "OBSOLETE. Any serine transmembrane transporter activity that is involved in serine import into cell." [GO_REF:0000061, GOC:TermGenie, ISBN:0-8249-3695-6]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "serine transmembrane transporter activity involved in serine import into cell" EXACT []
is_obsolete: true
created_by: dos
creation_date: 2014-07-09T11:56:44Z

[Term]
id: GO:1903163
name: obsolete sodium ion transmembrane transporter activity involved in sodium ion import into cell
namespace: molecular_function
def: "OBSOLETE. Any sodium ion transmembrane transporter activity that is involved in sodium ion import into cell." [GO_REF:0000061, GOC:TermGenie, ISBN:0-8249-3695-6]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "sodium ion transmembrane transporter activity involved in sodium ion import into cell" EXACT []
synonym: "sodium transporter activity involved in sodium ion import into cell" EXACT [GOC:TermGenie]
is_obsolete: true
created_by: dos
creation_date: 2014-07-09T11:56:49Z

[Term]
id: GO:1903164
name: obsolete succinate transmembrane transporter activity involved in succinate import into cell
namespace: molecular_function
def: "OBSOLETE. Any succinate transmembrane transporter activity that is involved in succinate import into cell." [GO_REF:0000061, GOC:TermGenie, ISBN:0-8249-3695-6]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity involved in succinate import into cell" RELATED [GOC:TermGenie]
synonym: "succinate transmembrane transporter activity involved in succinate import into cell" EXACT []
is_obsolete: true
created_by: dos
creation_date: 2014-07-09T11:56:55Z

[Term]
id: GO:1903165
name: response to polycyclic arene
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a polycyclic arene stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:10998501]
is_a: GO:0014070 ! response to organic cyclic compound
created_by: mr
creation_date: 2014-07-09T18:32:59Z

[Term]
id: GO:1903166
name: cellular response to polycyclic arene
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a polycyclic arene stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:10998501]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1903165 ! response to polycyclic arene
created_by: mr
creation_date: 2014-07-09T18:33:04Z

[Term]
id: GO:1903167
name: regulation of pyrroline-5-carboxylate reductase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pyrroline-5-carboxylate reductase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "regulation of 1-pyrroline-5-carboxylate reductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of L-proline oxidase activity" EXACT [GOC:TermGenie]
synonym: "regulation of L-proline-NAD(P)+ 5-oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of L-proline:NAD(P)+ 5-oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of NADPH-L-delta1-pyrroline carboxylic acid reductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of P5CR activity" EXACT [GOC:TermGenie]
is_a: GO:0051341 ! regulation of oxidoreductase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004735 ! pyrroline-5-carboxylate reductase activity
relationship: regulates GO:0004735 ! pyrroline-5-carboxylate reductase activity
created_by: bf
creation_date: 2014-07-09T19:51:19Z

[Term]
id: GO:1903168
name: positive regulation of pyrroline-5-carboxylate reductase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pyrroline-5-carboxylate reductase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23743200]
synonym: "activation of 1-pyrroline-5-carboxylate reductase activity" NARROW [GOC:TermGenie]
synonym: "activation of L-proline oxidase activity" NARROW [GOC:TermGenie]
synonym: "activation of L-proline-NAD(P)+ 5-oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "activation of L-proline:NAD(P)+ 5-oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "activation of NADPH-L-delta1-pyrroline carboxylic acid reductase activity" NARROW [GOC:TermGenie]
synonym: "activation of P5CR activity" NARROW [GOC:TermGenie]
synonym: "activation of pyrroline-5-carboxylate reductase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of 1-pyrroline-5-carboxylate reductase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of L-proline oxidase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of L-proline-NAD(P)+ 5-oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of L-proline:NAD(P)+ 5-oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of NADPH-L-delta1-pyrroline carboxylic acid reductase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of P5CR activity" EXACT [GOC:TermGenie]
synonym: "up regulation of 1-pyrroline-5-carboxylate reductase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of L-proline oxidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of L-proline-NAD(P)+ 5-oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of L-proline:NAD(P)+ 5-oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of NADPH-L-delta1-pyrroline carboxylic acid reductase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of P5CR activity" EXACT [GOC:TermGenie]
synonym: "up regulation of pyrroline-5-carboxylate reductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of 1-pyrroline-5-carboxylate reductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-proline oxidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-proline-NAD(P)+ 5-oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-proline:NAD(P)+ 5-oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of NADPH-L-delta1-pyrroline carboxylic acid reductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of P5CR activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of pyrroline-5-carboxylate reductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of 1-pyrroline-5-carboxylate reductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of L-proline oxidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of L-proline-NAD(P)+ 5-oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of L-proline:NAD(P)+ 5-oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of NADPH-L-delta1-pyrroline carboxylic acid reductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of P5CR activity" EXACT [GOC:TermGenie]
synonym: "upregulation of pyrroline-5-carboxylate reductase activity" EXACT [GOC:TermGenie]
is_a: GO:0051353 ! positive regulation of oxidoreductase activity
is_a: GO:1903167 ! regulation of pyrroline-5-carboxylate reductase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004735 ! pyrroline-5-carboxylate reductase activity
relationship: positively_regulates GO:0004735 ! pyrroline-5-carboxylate reductase activity
created_by: bf
creation_date: 2014-07-09T19:51:25Z

[Term]
id: GO:1903169
name: regulation of calcium ion transmembrane transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of calcium ion transmembrane transport." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:24125847]
comment: human HRC regulates RYR2 and thus regulates transmembrane transport of calcium from SR to cytosol
synonym: "regulation of calcium ion membrane transport" EXACT [GOC:TermGenie]
synonym: "regulation of transmembrane calcium transport" EXACT [GOC:TermGenie]
is_a: GO:0051924 ! regulation of calcium ion transport
is_a: GO:1904062 ! regulation of cation transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070588 ! calcium ion transmembrane transport
relationship: regulates GO:0070588 ! calcium ion transmembrane transport
created_by: rl
creation_date: 2014-07-11T17:09:26Z

[Term]
id: GO:1903170
name: negative regulation of calcium ion transmembrane transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion transmembrane transport." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:24125847]
comment: human HRC regulates RYR2 and thus regulates transmembrane transport of calcium from SR to cytosol
synonym: "down regulation of calcium ion membrane transport" EXACT [GOC:TermGenie]
synonym: "down regulation of calcium ion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "down regulation of transmembrane calcium transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of calcium ion membrane transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of calcium ion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of transmembrane calcium transport" EXACT [GOC:TermGenie]
synonym: "downregulation of calcium ion membrane transport" EXACT [GOC:TermGenie]
synonym: "downregulation of calcium ion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "downregulation of transmembrane calcium transport" EXACT [GOC:TermGenie]
synonym: "inhibition of calcium ion membrane transport" NARROW [GOC:TermGenie]
synonym: "inhibition of calcium ion transmembrane transport" NARROW [GOC:TermGenie]
synonym: "inhibition of transmembrane calcium transport" NARROW [GOC:TermGenie]
synonym: "negative regulation of calcium ion membrane transport" EXACT [GOC:TermGenie]
synonym: "negative regulation of transmembrane calcium transport" EXACT [GOC:TermGenie]
is_a: GO:0051926 ! negative regulation of calcium ion transport
is_a: GO:1903169 ! regulation of calcium ion transmembrane transport
is_a: GO:1904063 ! negative regulation of cation transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070588 ! calcium ion transmembrane transport
relationship: negatively_regulates GO:0070588 ! calcium ion transmembrane transport
created_by: rl
creation_date: 2014-07-11T17:09:32Z

[Term]
id: GO:1903171
name: carbon dioxide homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state of carbon dioxide within an organism or cell." [GO_REF:0000072, GOC:mr, GOC:TermGenie, PMID:16571594]
is_a: GO:0048878 ! chemical homeostasis
created_by: mr
creation_date: 2014-07-11T20:58:24Z

[Term]
id: GO:1903172
name: cellular carbon dioxide homeostasis
namespace: biological_process
def: "Any biological process involved in the maintenance of an internal steady state of carbon dioxide at the level of the cell." [GO_REF:0000072, GOC:mr, GOC:TermGenie, PMID:16571594]
is_a: GO:0055082 ! cellular chemical homeostasis
is_a: GO:1903171 ! carbon dioxide homeostasis
created_by: mr
creation_date: 2014-07-11T20:58:30Z

[Term]
id: GO:1903173
name: fatty alcohol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fatty alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:24036493]
synonym: "fatty alcohol metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006066 ! alcohol metabolic process
is_a: GO:0006629 ! lipid metabolic process
created_by: tt
creation_date: 2014-07-14T01:51:41Z

[Term]
id: GO:1903174
name: fatty alcohol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of fatty alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:24036493]
synonym: "fatty alcohol breakdown" EXACT [GOC:TermGenie]
synonym: "fatty alcohol catabolism" EXACT [GOC:TermGenie]
synonym: "fatty alcohol degradation" EXACT [GOC:TermGenie]
is_a: GO:0016042 ! lipid catabolic process
is_a: GO:0046164 ! alcohol catabolic process
is_a: GO:1903173 ! fatty alcohol metabolic process
created_by: tt
creation_date: 2014-07-14T01:51:48Z

[Term]
id: GO:1903175
name: fatty alcohol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of fatty alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:24036493]
synonym: "fatty alcohol anabolism" EXACT [GOC:TermGenie]
synonym: "fatty alcohol biosynthesis" EXACT [GOC:TermGenie]
synonym: "fatty alcohol formation" EXACT [GOC:TermGenie]
synonym: "fatty alcohol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0008610 ! lipid biosynthetic process
is_a: GO:0046165 ! alcohol biosynthetic process
is_a: GO:1903173 ! fatty alcohol metabolic process
created_by: tt
creation_date: 2014-07-14T01:51:54Z

[Term]
id: GO:1903176
name: regulation of tyrosine 3-monooxygenase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tyrosine 3-monooxygenase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "regulation of L-tyrosine hydroxylase activity" EXACT [GOC:TermGenie]
synonym: "regulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" EXACT [GOC:TermGenie]
synonym: "regulation of tyrosine 3-hydroxylase activity" EXACT [GOC:TermGenie]
synonym: "regulation of tyrosine hydroxylase activity" EXACT [GOC:TermGenie]
is_a: GO:0032768 ! regulation of monooxygenase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004511 ! tyrosine 3-monooxygenase activity
relationship: regulates GO:0004511 ! tyrosine 3-monooxygenase activity
created_by: bf
creation_date: 2014-07-14T10:39:09Z

[Term]
id: GO:1903177
name: negative regulation of tyrosine 3-monooxygenase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tyrosine 3-monooxygenase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "down regulation of L-tyrosine hydroxylase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" EXACT [GOC:TermGenie]
synonym: "down regulation of tyrosine 3-hydroxylase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of tyrosine 3-monooxygenase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of tyrosine hydroxylase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of L-tyrosine hydroxylase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" EXACT [GOC:TermGenie]
synonym: "down-regulation of tyrosine 3-hydroxylase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of tyrosine 3-monooxygenase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of tyrosine hydroxylase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of L-tyrosine hydroxylase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" EXACT [GOC:TermGenie]
synonym: "downregulation of tyrosine 3-hydroxylase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of tyrosine 3-monooxygenase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of tyrosine hydroxylase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of L-tyrosine hydroxylase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" NARROW [GOC:TermGenie]
synonym: "inhibition of tyrosine 3-hydroxylase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of tyrosine 3-monooxygenase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of tyrosine hydroxylase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of L-tyrosine hydroxylase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" EXACT [GOC:TermGenie]
synonym: "negative regulation of tyrosine 3-hydroxylase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of tyrosine hydroxylase activity" EXACT [GOC:TermGenie]
is_a: GO:0032769 ! negative regulation of monooxygenase activity
is_a: GO:1903176 ! regulation of tyrosine 3-monooxygenase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004511 ! tyrosine 3-monooxygenase activity
relationship: negatively_regulates GO:0004511 ! tyrosine 3-monooxygenase activity
created_by: bf
creation_date: 2014-07-14T10:39:15Z

[Term]
id: GO:1903178
name: positive regulation of tyrosine 3-monooxygenase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tyrosine 3-monooxygenase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19703902]
synonym: "activation of L-tyrosine hydroxylase activity" NARROW [GOC:TermGenie]
synonym: "activation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" NARROW [GOC:TermGenie]
synonym: "activation of tyrosine 3-hydroxylase activity" NARROW [GOC:TermGenie]
synonym: "activation of tyrosine 3-monooxygenase activity" NARROW [GOC:TermGenie]
synonym: "activation of tyrosine hydroxylase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of L-tyrosine hydroxylase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" EXACT [GOC:TermGenie]
synonym: "positive regulation of TH activity" EXACT [PMID:19703902]
synonym: "positive regulation of tyrosine 3-hydroxylase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of tyrosine hydroxylase activity" EXACT [GOC:TermGenie]
synonym: "stimulation of TH activity" EXACT [PMID:19703902]
synonym: "up regulation of L-tyrosine hydroxylase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" EXACT [GOC:TermGenie]
synonym: "up regulation of tyrosine 3-hydroxylase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of tyrosine 3-monooxygenase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of tyrosine hydroxylase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-tyrosine hydroxylase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" EXACT [GOC:TermGenie]
synonym: "up-regulation of tyrosine 3-hydroxylase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of tyrosine 3-monooxygenase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of tyrosine hydroxylase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of L-tyrosine hydroxylase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" EXACT [GOC:TermGenie]
synonym: "upregulation of tyrosine 3-hydroxylase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of tyrosine 3-monooxygenase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of tyrosine hydroxylase activity" EXACT [GOC:TermGenie]
is_a: GO:0032770 ! positive regulation of monooxygenase activity
is_a: GO:1903176 ! regulation of tyrosine 3-monooxygenase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004511 ! tyrosine 3-monooxygenase activity
relationship: positively_regulates GO:0004511 ! tyrosine 3-monooxygenase activity
created_by: bf
creation_date: 2014-07-14T10:39:21Z

[Term]
id: GO:1903179
name: regulation of dopamine biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dopamine biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "regulation of dopamine anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of dopamine biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of dopamine formation" EXACT [GOC:TermGenie]
synonym: "regulation of dopamine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0042053 ! regulation of dopamine metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042416 ! dopamine biosynthetic process
relationship: regulates GO:0042416 ! dopamine biosynthetic process
created_by: bf
creation_date: 2014-07-14T12:17:41Z

[Term]
id: GO:1903180
name: negative regulation of dopamine biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of dopamine biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "down regulation of dopamine anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of dopamine biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of dopamine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of dopamine formation" EXACT [GOC:TermGenie]
synonym: "down regulation of dopamine synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of dopamine anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of dopamine biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of dopamine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of dopamine formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of dopamine synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of dopamine anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of dopamine biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of dopamine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of dopamine formation" EXACT [GOC:TermGenie]
synonym: "downregulation of dopamine synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of dopamine anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of dopamine biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of dopamine biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of dopamine formation" NARROW [GOC:TermGenie]
synonym: "inhibition of dopamine synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of dopamine anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of dopamine biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of dopamine formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of dopamine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0045963 ! negative regulation of dopamine metabolic process
is_a: GO:1903179 ! regulation of dopamine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042416 ! dopamine biosynthetic process
relationship: negatively_regulates GO:0042416 ! dopamine biosynthetic process
created_by: bf
creation_date: 2014-07-14T12:17:47Z

[Term]
id: GO:1903181
name: positive regulation of dopamine biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of dopamine biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19703902]
synonym: "activation of dopamine anabolism" NARROW [GOC:TermGenie]
synonym: "activation of dopamine biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of dopamine biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of dopamine formation" NARROW [GOC:TermGenie]
synonym: "activation of dopamine synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of dopamine anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of dopamine biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of dopamine formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of dopamine synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of dopamine anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of dopamine biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of dopamine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of dopamine formation" EXACT [GOC:TermGenie]
synonym: "up regulation of dopamine synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of dopamine anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of dopamine biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of dopamine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of dopamine formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of dopamine synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of dopamine anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of dopamine biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of dopamine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of dopamine formation" EXACT [GOC:TermGenie]
synonym: "upregulation of dopamine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0045964 ! positive regulation of dopamine metabolic process
is_a: GO:1903179 ! regulation of dopamine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042416 ! dopamine biosynthetic process
relationship: positively_regulates GO:0042416 ! dopamine biosynthetic process
created_by: bf
creation_date: 2014-07-14T12:17:53Z

[Term]
id: GO:1903182
name: regulation of SUMO transferase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of SUMO ligase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "regulation of SMT3 conjugating enzyme" EXACT [GOC:TermGenie]
synonym: "regulation of SUMO conjugating enzyme activity" EXACT [GOC:TermGenie]
is_a: GO:0051338 ! regulation of transferase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019789 ! SUMO transferase activity
relationship: regulates GO:0019789 ! SUMO transferase activity
created_by: bf
creation_date: 2014-07-14T14:01:40Z

[Term]
id: GO:1903183
name: negative regulation of SUMO transferase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of SUMO ligase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:16731528]
synonym: "down regulation of SMT3 conjugating enzyme" EXACT [GOC:TermGenie]
synonym: "down regulation of SUMO conjugating enzyme activity" EXACT [GOC:TermGenie]
synonym: "down regulation of SUMO ligase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of SMT3 conjugating enzyme" EXACT [GOC:TermGenie]
synonym: "down-regulation of SUMO conjugating enzyme activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of SUMO ligase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of SMT3 conjugating enzyme" EXACT [GOC:TermGenie]
synonym: "downregulation of SUMO conjugating enzyme activity" EXACT [GOC:TermGenie]
synonym: "downregulation of SUMO ligase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of SMT3 conjugating enzyme" NARROW [GOC:TermGenie]
synonym: "inhibition of SUMO conjugating enzyme activity" NARROW [GOC:TermGenie]
synonym: "inhibition of SUMO ligase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of SMT3 conjugating enzyme" EXACT [GOC:TermGenie]
synonym: "negative regulation of SUMO conjugating enzyme activity" EXACT [GOC:TermGenie]
is_a: GO:0051348 ! negative regulation of transferase activity
is_a: GO:0051352 ! negative regulation of ligase activity
is_a: GO:1903182 ! regulation of SUMO transferase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019789 ! SUMO transferase activity
relationship: negatively_regulates GO:0019789 ! SUMO transferase activity
created_by: bf
creation_date: 2014-07-14T14:01:46Z

[Term]
id: GO:1903184
name: L-dopa metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving L-dopa." [GO_REF:0000068, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:8822146]
synonym: "L-dopa metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006575 ! cellular modified amino acid metabolic process
is_a: GO:1901605 ! alpha-amino acid metabolic process
created_by: bf
creation_date: 2014-07-14T15:06:00Z

[Term]
id: GO:1903185
name: L-dopa biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-dopa." [GO_REF:0000068, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:8822146]
synonym: "L-dopa anabolism" EXACT [GOC:TermGenie]
synonym: "L-dopa biosynthesis" EXACT [GOC:TermGenie]
synonym: "L-dopa formation" EXACT [GOC:TermGenie]
synonym: "L-dopa synthesis" EXACT [GOC:TermGenie]
is_a: GO:0042398 ! cellular modified amino acid biosynthetic process
is_a: GO:1901607 ! alpha-amino acid biosynthetic process
is_a: GO:1903184 ! L-dopa metabolic process
created_by: bf
creation_date: 2014-07-14T15:06:06Z

[Term]
id: GO:1903186
name: regulation of vitellogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vitellogenesis." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:19467235]
synonym: "regulation of yolk production" EXACT [GOC:TermGenie]
is_a: GO:0043900 ! regulation of multi-organism process
is_a: GO:0051128 ! regulation of cellular component organization
is_a: GO:0051239 ! regulation of multicellular organismal process
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007296 ! vitellogenesis
relationship: regulates GO:0007296 ! vitellogenesis
created_by: mr
creation_date: 2014-07-14T19:28:00Z

[Term]
id: GO:1903187
name: negative regulation of vitellogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vitellogenesis." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:19467235]
synonym: "down regulation of vitellogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of yolk production" EXACT [GOC:TermGenie]
synonym: "down-regulation of vitellogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of yolk production" EXACT [GOC:TermGenie]
synonym: "downregulation of vitellogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of yolk production" EXACT [GOC:TermGenie]
synonym: "inhibition of vitellogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of yolk production" NARROW [GOC:TermGenie]
synonym: "negative regulation of yolk production" EXACT [GOC:TermGenie]
is_a: GO:0043901 ! negative regulation of multi-organism process
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1903186 ! regulation of vitellogenesis
is_a: GO:2000242 ! negative regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007296 ! vitellogenesis
relationship: negatively_regulates GO:0007296 ! vitellogenesis
created_by: mr
creation_date: 2014-07-14T19:28:06Z

[Term]
id: GO:1903188
name: positive regulation of vitellogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vitellogenesis." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:19467235]
synonym: "activation of vitellogenesis" NARROW [GOC:TermGenie]
synonym: "activation of yolk production" NARROW [GOC:TermGenie]
synonym: "positive regulation of yolk production" EXACT [GOC:TermGenie]
synonym: "up regulation of vitellogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of yolk production" EXACT [GOC:TermGenie]
synonym: "up-regulation of vitellogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of yolk production" EXACT [GOC:TermGenie]
synonym: "upregulation of vitellogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of yolk production" EXACT [GOC:TermGenie]
is_a: GO:0043902 ! positive regulation of multi-organism process
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1903186 ! regulation of vitellogenesis
is_a: GO:2000243 ! positive regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007296 ! vitellogenesis
relationship: positively_regulates GO:0007296 ! vitellogenesis
created_by: mr
creation_date: 2014-07-14T19:28:12Z

[Term]
id: GO:1903189
name: glyoxal metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glyoxal." [GO_REF:0000068, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "glyoxal metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006081 ! cellular aldehyde metabolic process
created_by: bf
creation_date: 2014-07-15T10:11:45Z

[Term]
id: GO:1903190
name: glyoxal catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glyoxal." [GO_REF:0000068, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22523093, PMID:23651081]
synonym: "glyoxal breakdown" EXACT [GOC:TermGenie]
synonym: "glyoxal catabolism" EXACT [GOC:TermGenie]
synonym: "glyoxal degradation" EXACT [GOC:TermGenie]
is_a: GO:0046185 ! aldehyde catabolic process
is_a: GO:1903189 ! glyoxal metabolic process
created_by: bf
creation_date: 2014-07-15T10:11:51Z

[Term]
id: GO:1903191
name: glyoxal biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glyoxal." [GO_REF:0000068, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "glyoxal anabolism" EXACT [GOC:TermGenie]
synonym: "glyoxal biosynthesis" EXACT [GOC:TermGenie]
synonym: "glyoxal formation" EXACT [GOC:TermGenie]
synonym: "glyoxal synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046184 ! aldehyde biosynthetic process
is_a: GO:1903189 ! glyoxal metabolic process
created_by: bf
creation_date: 2014-07-15T10:11:57Z

[Term]
id: GO:1903192
name: sesquarterpene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sesquarterpene." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:21627333]
synonym: "sesquarterpene metabolism" EXACT [GOC:TermGenie]
is_a: GO:0042214 ! terpene metabolic process
created_by: tt
creation_date: 2014-07-16T17:04:47Z

[Term]
id: GO:1903193
name: sesquarterpene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sesquarterpene." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:21627333]
synonym: "sesquarterpene anabolism" EXACT [GOC:TermGenie]
synonym: "sesquarterpene biosynthesis" EXACT [GOC:TermGenie]
synonym: "sesquarterpene formation" EXACT [GOC:TermGenie]
synonym: "sesquarterpene synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046246 ! terpene biosynthetic process
is_a: GO:1903192 ! sesquarterpene metabolic process
created_by: tt
creation_date: 2014-07-16T17:04:53Z

[Term]
id: GO:1903195
name: regulation of L-dopa biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of L-dopa biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "regulation of L-dopa anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of L-dopa biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of L-dopa formation" EXACT [GOC:TermGenie]
synonym: "regulation of L-dopa synthesis" EXACT [GOC:TermGenie]
is_a: GO:2000282 ! regulation of cellular amino acid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1903185 ! L-dopa biosynthetic process
relationship: regulates GO:1903185 ! L-dopa biosynthetic process
created_by: bf
creation_date: 2014-07-21T09:12:37Z

[Term]
id: GO:1903196
name: negative regulation of L-dopa biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of L-dopa biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "down regulation of L-dopa anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of L-dopa biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of L-dopa biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of L-dopa formation" EXACT [GOC:TermGenie]
synonym: "down regulation of L-dopa synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of L-dopa anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of L-dopa biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of L-dopa biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of L-dopa formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of L-dopa synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of L-dopa anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of L-dopa biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of L-dopa biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of L-dopa formation" EXACT [GOC:TermGenie]
synonym: "downregulation of L-dopa synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of L-dopa anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of L-dopa biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of L-dopa biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of L-dopa formation" NARROW [GOC:TermGenie]
synonym: "inhibition of L-dopa synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of L-dopa anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of L-dopa biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of L-dopa formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of L-dopa synthesis" EXACT [GOC:TermGenie]
is_a: GO:1903195 ! regulation of L-dopa biosynthetic process
is_a: GO:2000283 ! negative regulation of cellular amino acid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1903185 ! L-dopa biosynthetic process
relationship: negatively_regulates GO:1903185 ! L-dopa biosynthetic process
created_by: bf
creation_date: 2014-07-21T09:12:44Z

[Term]
id: GO:1903197
name: positive regulation of L-dopa biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of L-dopa biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:16731528]
synonym: "activation of L-dopa anabolism" NARROW [GOC:TermGenie]
synonym: "activation of L-dopa biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of L-dopa biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of L-dopa formation" NARROW [GOC:TermGenie]
synonym: "activation of L-dopa synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of L-dopa anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of L-dopa biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of L-dopa formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of L-dopa synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of L-dopa anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of L-dopa biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of L-dopa biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of L-dopa formation" EXACT [GOC:TermGenie]
synonym: "up regulation of L-dopa synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-dopa anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-dopa biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-dopa biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-dopa formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-dopa synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of L-dopa anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of L-dopa biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of L-dopa biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of L-dopa formation" EXACT [GOC:TermGenie]
synonym: "upregulation of L-dopa synthesis" EXACT [GOC:TermGenie]
is_a: GO:1903195 ! regulation of L-dopa biosynthetic process
is_a: GO:2000284 ! positive regulation of cellular amino acid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1903185 ! L-dopa biosynthetic process
relationship: positively_regulates GO:1903185 ! L-dopa biosynthetic process
created_by: bf
creation_date: 2014-07-21T09:12:49Z

[Term]
id: GO:1903198
name: regulation of L-dopa decarboxylase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of L-dopa decarboxylase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "regulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity" EXACT [GOC:TermGenie]
synonym: "regulation of DDC activity" EXACT [GOC:TermGenie]
synonym: "regulation of DOPA decarboxylase activity" EXACT [GOC:TermGenie]
is_a: GO:0051339 ! regulation of lyase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0036468 ! L-dopa decarboxylase activity
relationship: regulates GO:0036468 ! L-dopa decarboxylase activity
created_by: bf
creation_date: 2014-07-21T09:32:31Z

[Term]
id: GO:1903199
name: negative regulation of L-dopa decarboxylase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of L-dopa decarboxylase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "down regulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of DDC activity" EXACT [GOC:TermGenie]
synonym: "down regulation of DOPA decarboxylase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of L-dopa decarboxylase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of DDC activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of DOPA decarboxylase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of L-dopa decarboxylase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of DDC activity" EXACT [GOC:TermGenie]
synonym: "downregulation of DOPA decarboxylase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of L-dopa decarboxylase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of 4-dihydroxyl-L-phenylalanine decarboxylase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of DDC activity" NARROW [GOC:TermGenie]
synonym: "inhibition of DOPA decarboxylase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of L-dopa decarboxylase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of DDC activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of DOPA decarboxylase activity" EXACT [GOC:TermGenie]
is_a: GO:0051350 ! negative regulation of lyase activity
is_a: GO:1903198 ! regulation of L-dopa decarboxylase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0036468 ! L-dopa decarboxylase activity
relationship: negatively_regulates GO:0036468 ! L-dopa decarboxylase activity
created_by: bf
creation_date: 2014-07-21T09:32:37Z

[Term]
id: GO:1903200
name: positive regulation of L-dopa decarboxylase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of L-dopa decarboxylase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19703902]
synonym: "activation of 4-dihydroxyl-L-phenylalanine decarboxylase activity" NARROW [GOC:TermGenie]
synonym: "activation of DDC activity" NARROW [GOC:TermGenie]
synonym: "activation of DOPA decarboxylase activity" NARROW [GOC:TermGenie]
synonym: "activation of L-dopa decarboxylase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of DDC activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of DOPA decarboxylase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of DDC activity" EXACT [GOC:TermGenie]
synonym: "up regulation of DOPA decarboxylase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of L-dopa decarboxylase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of DDC activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of DOPA decarboxylase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-dopa decarboxylase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of DDC activity" EXACT [GOC:TermGenie]
synonym: "upregulation of DOPA decarboxylase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of L-dopa decarboxylase activity" EXACT [GOC:TermGenie]
is_a: GO:0051349 ! positive regulation of lyase activity
is_a: GO:1903198 ! regulation of L-dopa decarboxylase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0036468 ! L-dopa decarboxylase activity
relationship: positively_regulates GO:0036468 ! L-dopa decarboxylase activity
created_by: bf
creation_date: 2014-07-21T09:32:43Z

[Term]
id: GO:1903201
name: regulation of oxidative stress-induced cell death
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of oxidative stress-induced cell death." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "regulation of cell death in response to oxidative stress" EXACT [GOC:bf]
is_a: GO:0010941 ! regulation of cell death
is_a: GO:1900407 ! regulation of cellular response to oxidative stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0036473 ! cell death in response to oxidative stress
relationship: regulates GO:0036473 ! cell death in response to oxidative stress
created_by: bf
creation_date: 2014-07-21T16:10:30Z

[Term]
id: GO:1903202
name: negative regulation of oxidative stress-induced cell death
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of oxidative stress-induced cell death." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804]
synonym: "down regulation of cell death in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell death in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "downregulation of cell death in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "inhibition of cell death in response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "negative regulation of cell death in response to oxidative stress" EXACT [GOC:bf]
synonym: "protection against oxidative stress-induced cell death" RELATED [GOC:bf]
is_a: GO:0060548 ! negative regulation of cell death
is_a: GO:1900408 ! negative regulation of cellular response to oxidative stress
is_a: GO:1903201 ! regulation of oxidative stress-induced cell death
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0036473 ! cell death in response to oxidative stress
relationship: negatively_regulates GO:0036473 ! cell death in response to oxidative stress
created_by: bf
creation_date: 2014-07-21T16:10:36Z

[Term]
id: GO:1903203
name: regulation of oxidative stress-induced neuron death
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of oxidative stress-induced neuron death." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "regulation of neuron death in response to oxidative stress" EXACT [GOC:bf]
synonym: "regulation of neuronal cell death in response to oxidative stress" EXACT [GOC:TermGenie]
is_a: GO:1901214 ! regulation of neuron death
is_a: GO:1903201 ! regulation of oxidative stress-induced cell death
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0036475 ! neuron death in response to oxidative stress
relationship: regulates GO:0036475 ! neuron death in response to oxidative stress
created_by: bf
creation_date: 2014-07-21T16:17:30Z

[Term]
id: GO:1903204
name: negative regulation of oxidative stress-induced neuron death
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of oxidative stress-induced neuron death." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804]
synonym: "down regulation of neuron death in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "down regulation of neuronal cell death in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "down regulation of oxidative stress-induced neuron death" EXACT [GOC:TermGenie]
synonym: "down-regulation of neuron death in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of neuronal cell death in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of oxidative stress-induced neuron death" EXACT [GOC:TermGenie]
synonym: "downregulation of neuron death in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "downregulation of neuronal cell death in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "downregulation of oxidative stress-induced neuron death" EXACT [GOC:TermGenie]
synonym: "inhibition of neuron death in response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "inhibition of neuronal cell death in response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "inhibition of oxidative stress-induced neuron death" NARROW [GOC:TermGenie]
synonym: "negative regulation of neuronal cell death in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "neuronal protection under oxidative stress" RELATED [GOC:bf]
synonym: "neuroprotection against oxidative stress" RELATED [GOC:bf]
is_a: GO:1901215 ! negative regulation of neuron death
is_a: GO:1903202 ! negative regulation of oxidative stress-induced cell death
is_a: GO:1903203 ! regulation of oxidative stress-induced neuron death
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0036475 ! neuron death in response to oxidative stress
relationship: negatively_regulates GO:0036475 ! neuron death in response to oxidative stress
created_by: bf
creation_date: 2014-07-21T16:17:36Z

[Term]
id: GO:1903205
name: regulation of hydrogen peroxide-induced cell death
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hydrogen peroxide-induced cell death." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "protection against hydrogen peroxide-mediated cell death" RELATED [GOC:bf]
synonym: "regulation of cell death in response to H2O2" EXACT [GOC:TermGenie]
synonym: "regulation of cell death in response to hydrogen peroxide" EXACT [GOC:bf]
synonym: "regulation of hydrogen peroxide-mediated cell death" RELATED [GOC:TermGenie]
is_a: GO:1901031 ! regulation of response to reactive oxygen species
is_a: GO:1903201 ! regulation of oxidative stress-induced cell death
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0036474 ! cell death in response to hydrogen peroxide
relationship: regulates GO:0036474 ! cell death in response to hydrogen peroxide
created_by: bf
creation_date: 2014-07-21T16:21:47Z

[Term]
id: GO:1903206
name: negative regulation of hydrogen peroxide-induced cell death
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide-induced cell death." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:14749723, PMID:24252804]
synonym: "down regulation of cell death in response to H2O2" EXACT [GOC:TermGenie]
synonym: "down regulation of cell death in response to hydrogen peroxide" EXACT [GOC:TermGenie]
synonym: "down regulation of hydrogen peroxide-mediated cell death" RELATED [GOC:TermGenie]
synonym: "down-regulation of cell death in response to H2O2" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell death in response to hydrogen peroxide" EXACT [GOC:TermGenie]
synonym: "down-regulation of hydrogen peroxide-mediated cell death" RELATED [GOC:TermGenie]
synonym: "downregulation of cell death in response to H2O2" EXACT [GOC:TermGenie]
synonym: "downregulation of cell death in response to hydrogen peroxide" EXACT [GOC:TermGenie]
synonym: "downregulation of hydrogen peroxide-mediated cell death" RELATED [GOC:TermGenie]
synonym: "inhibition of cell death in response to H2O2" NARROW [GOC:TermGenie]
synonym: "inhibition of cell death in response to hydrogen peroxide" NARROW [GOC:TermGenie]
synonym: "inhibition of hydrogen peroxide-mediated cell death" RELATED [GOC:TermGenie]
synonym: "negative regulation of cell death in response to H2O2" EXACT [GOC:TermGenie]
synonym: "negative regulation of cell death in response to hydrogen peroxide" EXACT [GOC:bf]
synonym: "negative regulation of hydrogen peroxide-mediated cell death" RELATED [GOC:TermGenie]
synonym: "protection against H2O2-induced cell death" RELATED [GOC:bf]
synonym: "protection against hydrogen peroxide-induced cell death" RELATED [GOC:bf]
is_a: GO:1901032 ! negative regulation of response to reactive oxygen species
is_a: GO:1903202 ! negative regulation of oxidative stress-induced cell death
is_a: GO:1903205 ! regulation of hydrogen peroxide-induced cell death
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0036474 ! cell death in response to hydrogen peroxide
relationship: negatively_regulates GO:0036474 ! cell death in response to hydrogen peroxide
created_by: bf
creation_date: 2014-07-21T16:21:53Z

[Term]
id: GO:1903207
name: regulation of hydrogen peroxide-induced neuron death
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hydrogen peroxide-induced neuron death." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "regulation of neuron death in response to H2O2" EXACT [GOC:TermGenie]
synonym: "regulation of neuron death in response to hydrogen peroxide" EXACT [GOC:bf]
synonym: "regulation of neuronal cell death in response to hydrogen peroxide" EXACT [GOC:TermGenie]
is_a: GO:1903203 ! regulation of oxidative stress-induced neuron death
is_a: GO:1903205 ! regulation of hydrogen peroxide-induced cell death
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0036476 ! neuron death in response to hydrogen peroxide
relationship: regulates GO:0036476 ! neuron death in response to hydrogen peroxide
created_by: bf
creation_date: 2014-07-21T16:27:05Z

[Term]
id: GO:1903208
name: negative regulation of hydrogen peroxide-induced neuron death
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide-induced neuron death." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804]
synonym: "down regulation of hydrogen peroxide-induced neuron death" EXACT [GOC:TermGenie]
synonym: "down regulation of neuron death in response to H2O2" EXACT [GOC:TermGenie]
synonym: "down regulation of neuron death in response to hydrogen peroxide" EXACT [GOC:TermGenie]
synonym: "down regulation of neuronal cell death in response to hydrogen peroxide" EXACT [GOC:TermGenie]
synonym: "down-regulation of hydrogen peroxide-induced neuron death" EXACT [GOC:TermGenie]
synonym: "down-regulation of neuron death in response to H2O2" EXACT [GOC:TermGenie]
synonym: "down-regulation of neuron death in response to hydrogen peroxide" EXACT [GOC:TermGenie]
synonym: "down-regulation of neuronal cell death in response to hydrogen peroxide" EXACT [GOC:TermGenie]
synonym: "downregulation of hydrogen peroxide-induced neuron death" EXACT [GOC:TermGenie]
synonym: "downregulation of neuron death in response to H2O2" EXACT [GOC:TermGenie]
synonym: "downregulation of neuron death in response to hydrogen peroxide" EXACT [GOC:TermGenie]
synonym: "downregulation of neuronal cell death in response to hydrogen peroxide" EXACT [GOC:TermGenie]
synonym: "inhibition of hydrogen peroxide-induced neuron death" NARROW [GOC:TermGenie]
synonym: "inhibition of neuron death in response to H2O2" NARROW [GOC:TermGenie]
synonym: "inhibition of neuron death in response to hydrogen peroxide" NARROW [GOC:TermGenie]
synonym: "inhibition of neuronal cell death in response to hydrogen peroxide" NARROW [GOC:TermGenie]
synonym: "negative regulation of neuron death in response to H2O2" EXACT [GOC:TermGenie]
synonym: "negative regulation of neuron death in response to hydrogen peroxide" EXACT [GOC:bf]
synonym: "negative regulation of neuronal cell death in response to hydrogen peroxide" EXACT [GOC:TermGenie]
synonym: "neuroprotection against H2O2-induced cell death" RELATED [GOC:bf]
synonym: "neuroprotection against hydrogen peroxide" RELATED [GOC:bf]
synonym: "protection against H2O2-induced neuron death" RELATED [GOC:bf]
synonym: "protection against hydrogen peroxide-induced neuron death" RELATED [GOC:bf]
is_a: GO:1903204 ! negative regulation of oxidative stress-induced neuron death
is_a: GO:1903206 ! negative regulation of hydrogen peroxide-induced cell death
is_a: GO:1903207 ! regulation of hydrogen peroxide-induced neuron death
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0036476 ! neuron death in response to hydrogen peroxide
relationship: negatively_regulates GO:0036476 ! neuron death in response to hydrogen peroxide
created_by: bf
creation_date: 2014-07-21T16:27:11Z

[Term]
id: GO:1903209
name: positive regulation of oxidative stress-induced cell death
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of oxidative stress-induced cell death." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:20969476]
synonym: "activation of cell death in response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "enhancement of oxidative stress-induced cell death" NARROW []
synonym: "positive regulation of cell death in response to oxidative stress" EXACT []
synonym: "up regulation of cell death in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell death in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "upregulation of cell death in response to oxidative stress" EXACT [GOC:TermGenie]
is_a: GO:0010942 ! positive regulation of cell death
is_a: GO:1900409 ! positive regulation of cellular response to oxidative stress
is_a: GO:1903201 ! regulation of oxidative stress-induced cell death
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0036473 ! cell death in response to oxidative stress
relationship: positively_regulates GO:0036473 ! cell death in response to oxidative stress
created_by: bf
creation_date: 2014-07-22T09:32:19Z

[Term]
id: GO:1903210
name: glomerular visceral epithelial cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a glomerular visceral epithelial cell." [GO_REF:0000085, GOC:TermGenie, PMID:23515840]
synonym: "glomerular podocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "glomerular podocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "podocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "podocyte apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:1904019 ! epithelial cell apoptotic process
created_by: sl
creation_date: 2014-07-23T17:07:55Z

[Term]
id: GO:1903211
name: mitotic recombination involved in replication fork processing
namespace: biological_process
def: "Any mitotic recombination that is involved in replication fork processing." [GO_REF:0000060, GOC:TermGenie, PMID:23093942]
synonym: "mitotic recombination involved in collapsed replication fork processing" EXACT [GOC:TermGenie]
synonym: "mitotic recombination involved in recovery from replication fork arrest" EXACT [GOC:TermGenie]
synonym: "mitotic recombination involved in recovery from replication fork stalling" EXACT [GOC:TermGenie]
synonym: "mitotic recombination involved in replication fork restart" RELATED [GOC:TermGenie]
synonym: "mitotic recombination involved in replication restart" RELATED [GOC:TermGenie]
is_a: GO:0006312 ! mitotic recombination
intersection_of: GO:0006312 ! mitotic recombination
intersection_of: part_of GO:0031297 ! replication fork processing
relationship: part_of GO:0031297 ! replication fork processing
created_by: mah
creation_date: 2014-07-24T09:33:40Z

[Term]
id: GO:1903212
name: protein localization to mating-type region heterochromatin
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a mating-type region heterochromatin." [GO_REF:0000087, GOC:TermGenie, PMID:18761674]
synonym: "protein localisation in mating-type region heterochromatin" EXACT [GOC:TermGenie]
synonym: "protein localisation to mating-type region heterochromatin" EXACT [GOC:TermGenie]
synonym: "protein localization in mating-type region heterochromatin" EXACT [GOC:TermGenie]
is_a: GO:0097355 ! protein localization to heterochromatin
created_by: mah
creation_date: 2014-07-24T09:38:12Z

[Term]
id: GO:1903213
name: protein localization to subtelomeric heterochromatin
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a subtelomeric heterochromatin." [GO_REF:0000087, GOC:TermGenie, SO:0001997]
synonym: "protein localisation in subtelomeric heterochromatin" EXACT [GOC:TermGenie]
synonym: "protein localisation to subtelomeric heterochromatin" EXACT [GOC:TermGenie]
synonym: "protein localization in subtelomeric heterochromatin" EXACT [GOC:TermGenie]
is_a: GO:0097355 ! protein localization to heterochromatin
created_by: mah
creation_date: 2014-07-24T09:38:18Z

[Term]
id: GO:1903214
name: regulation of protein targeting to mitochondrion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein targeting to mitochondrion." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "regulation of mitochondrial protein import" RELATED [GOC:TermGenie]
synonym: "regulation of mitochondrial translocation" RELATED [GOC:TermGenie]
synonym: "regulation of protein import into mitochondrion" EXACT [GOC:TermGenie]
synonym: "regulation of protein targeting to mitochondria" EXACT [GOC:TermGenie]
synonym: "regulation of protein-mitochondrial targeting" EXACT [GOC:TermGenie]
is_a: GO:0010821 ! regulation of mitochondrion organization
is_a: GO:1903533 ! regulation of protein targeting
is_a: GO:1903649 ! regulation of cytoplasmic transport
is_a: GO:1903747 ! regulation of establishment of protein localization to mitochondrion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006626 ! protein targeting to mitochondrion
relationship: regulates GO:0006626 ! protein targeting to mitochondrion
created_by: bf
creation_date: 2014-07-24T10:17:13Z

[Term]
id: GO:1903215
name: negative regulation of protein targeting to mitochondrion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein targeting to mitochondrion." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21370995]
synonym: "down regulation of mitochondrial protein import" RELATED [GOC:TermGenie]
synonym: "down regulation of mitochondrial translocation" RELATED [GOC:TermGenie]
synonym: "down regulation of protein import into mitochondrion" EXACT [GOC:TermGenie]
synonym: "down regulation of protein targeting to mitochondria" EXACT [GOC:TermGenie]
synonym: "down regulation of protein targeting to mitochondrion" EXACT [GOC:TermGenie]
synonym: "down regulation of protein-mitochondrial targeting" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitochondrial protein import" RELATED [GOC:TermGenie]
synonym: "down-regulation of mitochondrial translocation" RELATED [GOC:TermGenie]
synonym: "down-regulation of protein import into mitochondrion" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein targeting to mitochondria" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein targeting to mitochondrion" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein-mitochondrial targeting" EXACT [GOC:TermGenie]
synonym: "downregulation of mitochondrial protein import" RELATED [GOC:TermGenie]
synonym: "downregulation of mitochondrial translocation" RELATED [GOC:TermGenie]
synonym: "downregulation of protein import into mitochondrion" EXACT [GOC:TermGenie]
synonym: "downregulation of protein targeting to mitochondria" EXACT [GOC:TermGenie]
synonym: "downregulation of protein targeting to mitochondrion" EXACT [GOC:TermGenie]
synonym: "downregulation of protein-mitochondrial targeting" EXACT [GOC:TermGenie]
synonym: "inhibition of mitochondrial protein import" RELATED [GOC:TermGenie]
synonym: "inhibition of mitochondrial translocation" RELATED [GOC:TermGenie]
synonym: "inhibition of protein import into mitochondrion" NARROW [GOC:TermGenie]
synonym: "inhibition of protein targeting to mitochondria" NARROW [GOC:TermGenie]
synonym: "inhibition of protein targeting to mitochondrion" NARROW [GOC:TermGenie]
synonym: "inhibition of protein-mitochondrial targeting" NARROW [GOC:TermGenie]
synonym: "negative regulation of mitochondrial protein import" RELATED [GOC:TermGenie]
synonym: "negative regulation of mitochondrial translocation" RELATED [GOC:TermGenie]
synonym: "negative regulation of protein import into mitochondrion" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein targeting to mitochondria" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein-mitochondrial targeting" EXACT [GOC:TermGenie]
is_a: GO:0010823 ! negative regulation of mitochondrion organization
is_a: GO:0090317 ! negative regulation of intracellular protein transport
is_a: GO:1903214 ! regulation of protein targeting to mitochondrion
is_a: GO:1903650 ! negative regulation of cytoplasmic transport
is_a: GO:1903748 ! negative regulation of establishment of protein localization to mitochondrion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006626 ! protein targeting to mitochondrion
relationship: negatively_regulates GO:0006626 ! protein targeting to mitochondrion
created_by: bf
creation_date: 2014-07-24T10:17:19Z

[Term]
id: GO:1903216
name: regulation of protein processing involved in protein targeting to mitochondrion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein processing involved in protein targeting to mitochondrion." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21370995]
synonym: "regulation of mitochondrial processing" BROAD [GOC:TermGenie]
synonym: "regulation of mitochondrial protein processing during import" RELATED [GOC:TermGenie]
is_a: GO:0032268 ! regulation of cellular protein metabolic process
is_a: GO:0070613 ! regulation of protein processing
is_a: GO:1903214 ! regulation of protein targeting to mitochondrion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006627 ! protein processing involved in protein targeting to mitochondrion
relationship: regulates GO:0006627 ! protein processing involved in protein targeting to mitochondrion
created_by: bf
creation_date: 2014-07-24T10:20:54Z

[Term]
id: GO:1903217
name: negative regulation of protein processing involved in protein targeting to mitochondrion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein processing involved in protein targeting to mitochondrion." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21370995]
synonym: "down regulation of mitochondrial protein processing during import" RELATED [GOC:TermGenie]
synonym: "down regulation of protein processing involved in protein targeting to mitochondrion" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitochondrial protein processing during import" RELATED [GOC:TermGenie]
synonym: "down-regulation of protein processing involved in protein targeting to mitochondrion" EXACT [GOC:TermGenie]
synonym: "downregulation of mitochondrial protein processing during import" RELATED [GOC:TermGenie]
synonym: "downregulation of protein processing involved in protein targeting to mitochondrion" EXACT [GOC:TermGenie]
synonym: "inhibition of mitochondrial protein processing during import" RELATED [GOC:TermGenie]
synonym: "inhibition of protein processing involved in protein targeting to mitochondrion" NARROW [GOC:TermGenie]
synonym: "negative regulation of mitochondrial protein processing during import" RELATED [GOC:TermGenie]
is_a: GO:0010955 ! negative regulation of protein processing
is_a: GO:1903215 ! negative regulation of protein targeting to mitochondrion
is_a: GO:1903216 ! regulation of protein processing involved in protein targeting to mitochondrion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006627 ! protein processing involved in protein targeting to mitochondrion
relationship: negatively_regulates GO:0006627 ! protein processing involved in protein targeting to mitochondrion
created_by: bf
creation_date: 2014-07-24T10:21:00Z

[Term]
id: GO:1903218
name: regulation of malate dehydrogenase (decarboxylating) (NADP+) activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of malate dehydrogenase (decarboxylating) (NADP+) activity." [GO_REF:0000059, GOC:sart, GOC:TermGenie, PMID:12398416]
synonym: "regulation of 'malic' enzyme" RELATED [GOC:TermGenie]
synonym: "regulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" EXACT [GOC:TermGenie]
synonym: "regulation of L-malate:NADP oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of malate dehydrogenase (decarboxylating, NADP)" EXACT [GOC:TermGenie]
synonym: "regulation of malate dehydrogenase (NADP, decarboxylating)" EXACT [GOC:TermGenie]
synonym: "regulation of NADP-linked decarboxylating malic enzyme" RELATED [GOC:TermGenie]
synonym: "regulation of NADP-malic enzyme activity" EXACT [GOC:TermGenie]
synonym: "regulation of NADP-specific malate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "regulation of NADP-specific malic enzyme" RELATED [GOC:TermGenie]
is_a: GO:0051341 ! regulation of oxidoreductase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004473 ! malate dehydrogenase (decarboxylating) (NADP+) activity
relationship: regulates GO:0004473 ! malate dehydrogenase (decarboxylating) (NADP+) activity
created_by: sart
creation_date: 2014-07-24T11:17:22Z

[Term]
id: GO:1903219
name: negative regulation of malate dehydrogenase (decarboxylating) (NADP+) activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of malate dehydrogenase (decarboxylating) (NADP+) activity." [GO_REF:0000059, GOC:sart, GOC:TermGenie, PMID:12398416]
synonym: "down regulation of 'malic' enzyme" RELATED [GOC:TermGenie]
synonym: "down regulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" EXACT [GOC:TermGenie]
synonym: "down regulation of L-malate:NADP oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of malate dehydrogenase (decarboxylating) (NADP+) activity" EXACT [GOC:TermGenie]
synonym: "down regulation of malate dehydrogenase (decarboxylating, NADP)" EXACT [GOC:TermGenie]
synonym: "down regulation of malate dehydrogenase (NADP, decarboxylating)" EXACT [GOC:TermGenie]
synonym: "down regulation of NADP-linked decarboxylating malic enzyme" RELATED [GOC:TermGenie]
synonym: "down regulation of NADP-malic enzyme activity" EXACT [GOC:TermGenie]
synonym: "down regulation of NADP-specific malate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of NADP-specific malic enzyme" RELATED [GOC:TermGenie]
synonym: "down-regulation of 'malic' enzyme" RELATED [GOC:TermGenie]
synonym: "down-regulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" EXACT [GOC:TermGenie]
synonym: "down-regulation of L-malate:NADP oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of malate dehydrogenase (decarboxylating) (NADP+) activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of malate dehydrogenase (decarboxylating, NADP)" EXACT [GOC:TermGenie]
synonym: "down-regulation of malate dehydrogenase (NADP, decarboxylating)" EXACT [GOC:TermGenie]
synonym: "down-regulation of NADP-linked decarboxylating malic enzyme" RELATED [GOC:TermGenie]
synonym: "down-regulation of NADP-malic enzyme activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of NADP-specific malate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of NADP-specific malic enzyme" RELATED [GOC:TermGenie]
synonym: "downregulation of 'malic' enzyme" RELATED [GOC:TermGenie]
synonym: "downregulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" EXACT [GOC:TermGenie]
synonym: "downregulation of L-malate:NADP oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of malate dehydrogenase (decarboxylating) (NADP+) activity" EXACT [GOC:TermGenie]
synonym: "downregulation of malate dehydrogenase (decarboxylating, NADP)" EXACT [GOC:TermGenie]
synonym: "downregulation of malate dehydrogenase (NADP, decarboxylating)" EXACT [GOC:TermGenie]
synonym: "downregulation of NADP-linked decarboxylating malic enzyme" RELATED [GOC:TermGenie]
synonym: "downregulation of NADP-malic enzyme activity" EXACT [GOC:TermGenie]
synonym: "downregulation of NADP-specific malate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of NADP-specific malic enzyme" RELATED [GOC:TermGenie]
synonym: "inhibition of 'malic' enzyme" RELATED [GOC:TermGenie]
synonym: "inhibition of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" NARROW [GOC:TermGenie]
synonym: "inhibition of L-malate:NADP oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of malate dehydrogenase (decarboxylating) (NADP+) activity" NARROW [GOC:TermGenie]
synonym: "inhibition of malate dehydrogenase (decarboxylating, NADP)" NARROW [GOC:TermGenie]
synonym: "inhibition of malate dehydrogenase (NADP, decarboxylating)" NARROW [GOC:TermGenie]
synonym: "inhibition of NADP-linked decarboxylating malic enzyme" RELATED [GOC:TermGenie]
synonym: "inhibition of NADP-malic enzyme activity" NARROW [GOC:TermGenie]
synonym: "inhibition of NADP-specific malate dehydrogenase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of NADP-specific malic enzyme" RELATED [GOC:TermGenie]
synonym: "negative regulation of 'malic' enzyme" RELATED [GOC:TermGenie]
synonym: "negative regulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" EXACT [GOC:TermGenie]
synonym: "negative regulation of L-malate:NADP oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of malate dehydrogenase (decarboxylating, NADP)" EXACT [GOC:TermGenie]
synonym: "negative regulation of malate dehydrogenase (NADP, decarboxylating)" EXACT [GOC:TermGenie]
synonym: "negative regulation of NADP-linked decarboxylating malic enzyme" RELATED [GOC:TermGenie]
synonym: "negative regulation of NADP-malic enzyme activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of NADP-specific malate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of NADP-specific malic enzyme" RELATED [GOC:TermGenie]
is_a: GO:0051354 ! negative regulation of oxidoreductase activity
is_a: GO:1903218 ! regulation of malate dehydrogenase (decarboxylating) (NADP+) activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004473 ! malate dehydrogenase (decarboxylating) (NADP+) activity
relationship: negatively_regulates GO:0004473 ! malate dehydrogenase (decarboxylating) (NADP+) activity
created_by: sart
creation_date: 2014-07-24T11:17:28Z

[Term]
id: GO:1903220
name: positive regulation of malate dehydrogenase (decarboxylating) (NADP+) activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of malate dehydrogenase (decarboxylating) (NADP+) activity." [GO_REF:0000059, GOC:sart, GOC:TermGenie, PMID:12398416]
synonym: "activation of 'malic' enzyme" RELATED [GOC:TermGenie]
synonym: "activation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" NARROW [GOC:TermGenie]
synonym: "activation of L-malate:NADP oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "activation of malate dehydrogenase (decarboxylating) (NADP+) activity" NARROW [GOC:TermGenie]
synonym: "activation of malate dehydrogenase (decarboxylating, NADP)" NARROW [GOC:TermGenie]
synonym: "activation of malate dehydrogenase (NADP, decarboxylating)" NARROW [GOC:TermGenie]
synonym: "activation of NADP-linked decarboxylating malic enzyme" RELATED [GOC:TermGenie]
synonym: "activation of NADP-malic enzyme activity" NARROW [GOC:TermGenie]
synonym: "activation of NADP-specific malate dehydrogenase activity" NARROW [GOC:TermGenie]
synonym: "activation of NADP-specific malic enzyme" RELATED [GOC:TermGenie]
synonym: "positive regulation of 'malic' enzyme" RELATED [GOC:TermGenie]
synonym: "positive regulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" EXACT [GOC:TermGenie]
synonym: "positive regulation of L-malate:NADP oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of malate dehydrogenase (decarboxylating, NADP)" EXACT [GOC:TermGenie]
synonym: "positive regulation of malate dehydrogenase (NADP, decarboxylating)" EXACT [GOC:TermGenie]
synonym: "positive regulation of NADP-linked decarboxylating malic enzyme" RELATED [GOC:TermGenie]
synonym: "positive regulation of NADP-malic enzyme activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of NADP-specific malate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of NADP-specific malic enzyme" RELATED [GOC:TermGenie]
synonym: "up regulation of 'malic' enzyme" RELATED [GOC:TermGenie]
synonym: "up regulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" EXACT [GOC:TermGenie]
synonym: "up regulation of L-malate:NADP oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of malate dehydrogenase (decarboxylating) (NADP+) activity" EXACT [GOC:TermGenie]
synonym: "up regulation of malate dehydrogenase (decarboxylating, NADP)" EXACT [GOC:TermGenie]
synonym: "up regulation of malate dehydrogenase (NADP, decarboxylating)" EXACT [GOC:TermGenie]
synonym: "up regulation of NADP-linked decarboxylating malic enzyme" RELATED [GOC:TermGenie]
synonym: "up regulation of NADP-malic enzyme activity" EXACT [GOC:TermGenie]
synonym: "up regulation of NADP-specific malate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of NADP-specific malic enzyme" RELATED [GOC:TermGenie]
synonym: "up-regulation of 'malic' enzyme" RELATED [GOC:TermGenie]
synonym: "up-regulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-malate:NADP oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of malate dehydrogenase (decarboxylating) (NADP+) activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of malate dehydrogenase (decarboxylating, NADP)" EXACT [GOC:TermGenie]
synonym: "up-regulation of malate dehydrogenase (NADP, decarboxylating)" EXACT [GOC:TermGenie]
synonym: "up-regulation of NADP-linked decarboxylating malic enzyme" RELATED [GOC:TermGenie]
synonym: "up-regulation of NADP-malic enzyme activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of NADP-specific malate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of NADP-specific malic enzyme" RELATED [GOC:TermGenie]
synonym: "upregulation of 'malic' enzyme" RELATED [GOC:TermGenie]
synonym: "upregulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" EXACT [GOC:TermGenie]
synonym: "upregulation of L-malate:NADP oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of malate dehydrogenase (decarboxylating) (NADP+) activity" EXACT [GOC:TermGenie]
synonym: "upregulation of malate dehydrogenase (decarboxylating, NADP)" EXACT [GOC:TermGenie]
synonym: "upregulation of malate dehydrogenase (NADP, decarboxylating)" EXACT [GOC:TermGenie]
synonym: "upregulation of NADP-linked decarboxylating malic enzyme" RELATED [GOC:TermGenie]
synonym: "upregulation of NADP-malic enzyme activity" EXACT [GOC:TermGenie]
synonym: "upregulation of NADP-specific malate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of NADP-specific malic enzyme" RELATED [GOC:TermGenie]
is_a: GO:0051353 ! positive regulation of oxidoreductase activity
is_a: GO:1903218 ! regulation of malate dehydrogenase (decarboxylating) (NADP+) activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004473 ! malate dehydrogenase (decarboxylating) (NADP+) activity
relationship: positively_regulates GO:0004473 ! malate dehydrogenase (decarboxylating) (NADP+) activity
created_by: sart
creation_date: 2014-07-24T11:17:34Z

[Term]
id: GO:1903221
name: regulation of mitotic recombination involved in replication fork processing
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitotic recombination involved in replication fork processing. Regulation of mitotic recombination contributes to replication fork processing by preventing recombination between inappropriate homologous sequences." [GO_REF:0000058, GOC:TermGenie, PMID:23093942]
synonym: "prevention of genomic instability induced by DNA replication fork arrest" RELATED [PMID:23093942]
synonym: "regulation of mitotic recombination involved in collapsed replication fork processing" EXACT [GOC:TermGenie]
synonym: "regulation of mitotic recombination involved in recovery from replication fork arrest" EXACT [GOC:TermGenie]
synonym: "regulation of mitotic recombination involved in recovery from replication fork stalling" EXACT [GOC:TermGenie]
synonym: "regulation of mitotic recombination involved in replication fork restart" RELATED [GOC:TermGenie]
synonym: "regulation of mitotic recombination involved in replication restart" RELATED [GOC:TermGenie]
is_a: GO:0000019 ! regulation of mitotic recombination
is_a: GO:0090329 ! regulation of DNA-dependent DNA replication
is_a: GO:2001020 ! regulation of response to DNA damage stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1903211 ! mitotic recombination involved in replication fork processing
relationship: regulates GO:1903211 ! mitotic recombination involved in replication fork processing
created_by: mah
creation_date: 2014-07-24T13:30:21Z

[Term]
id: GO:1903222
name: quinolinic acid transmembrane transport
namespace: biological_process
def: "The directed movement of quinolinic acid across a membrane." [GO_REF:0000069, GOC:di, GOC:TermGenie, PMID:23457190]
is_a: GO:0006835 ! dicarboxylic acid transport
is_a: GO:0071705 ! nitrogen compound transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport
created_by: di
creation_date: 2014-07-26T07:29:07Z

[Term]
id: GO:1903223
name: positive regulation of oxidative stress-induced neuron death
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of oxidative stress-induced neuron death." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23858059]
synonym: "activation of neuron death in response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "activation of neuronal cell death in response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "activation of oxidative stress-induced neuron death" NARROW [GOC:TermGenie]
synonym: "positive regulation of neuron death in response to oxidative stress" EXACT [GOC:bf]
synonym: "positive regulation of neuronal cell death in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "sensitization of neuron to oxidative stress-induced cell death" RELATED [PMID:23858059]
synonym: "up regulation of neuron death in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "up regulation of neuronal cell death in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "up regulation of oxidative stress-induced neuron death" EXACT [GOC:TermGenie]
synonym: "up-regulation of neuron death in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of neuronal cell death in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of oxidative stress-induced neuron death" EXACT [GOC:TermGenie]
synonym: "upregulation of neuron death in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "upregulation of neuronal cell death in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "upregulation of oxidative stress-induced neuron death" EXACT [GOC:TermGenie]
is_a: GO:1901216 ! positive regulation of neuron death
is_a: GO:1903203 ! regulation of oxidative stress-induced neuron death
is_a: GO:1903209 ! positive regulation of oxidative stress-induced cell death
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0036475 ! neuron death in response to oxidative stress
relationship: positively_regulates GO:0036475 ! neuron death in response to oxidative stress
created_by: bf
creation_date: 2014-07-29T08:51:52Z

[Term]
id: GO:1903224
name: regulation of endodermal cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endodermal cell differentiation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23154389]
synonym: "regulation of endoderm cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0010470 ! regulation of gastrulation
is_a: GO:0045595 ! regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035987 ! endodermal cell differentiation
relationship: regulates GO:0035987 ! endodermal cell differentiation
created_by: als
creation_date: 2014-07-29T13:22:35Z

[Term]
id: GO:1903225
name: negative regulation of endodermal cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of endodermal cell differentiation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23154389]
synonym: "down regulation of endoderm cell differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of endodermal cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of endoderm cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of endodermal cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of endoderm cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of endodermal cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of endoderm cell differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of endodermal cell differentiation" NARROW [GOC:TermGenie]
synonym: "negative regulation of endoderm cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:1903224 ! regulation of endodermal cell differentiation
is_a: GO:2000542 ! negative regulation of gastrulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035987 ! endodermal cell differentiation
relationship: negatively_regulates GO:0035987 ! endodermal cell differentiation
created_by: als
creation_date: 2014-07-29T13:22:41Z

[Term]
id: GO:1903226
name: positive regulation of endodermal cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endodermal cell differentiation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23154389]
synonym: "activation of endoderm cell differentiation" NARROW [GOC:TermGenie]
synonym: "activation of endodermal cell differentiation" NARROW [GOC:TermGenie]
synonym: "positive regulation of endoderm cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of endoderm cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of endodermal cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of endoderm cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of endodermal cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of endoderm cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of endodermal cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:1903224 ! regulation of endodermal cell differentiation
is_a: GO:2000543 ! positive regulation of gastrulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035987 ! endodermal cell differentiation
relationship: positively_regulates GO:0035987 ! endodermal cell differentiation
created_by: als
creation_date: 2014-07-29T13:22:47Z

[Term]
id: GO:1903227
name: xanthosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving xanthosine." [GO_REF:0000068, GOC:TermGenie, PMID:7007809, PMID:7559336]
synonym: "xanthosine metabolism" EXACT [GOC:TermGenie]
is_a: GO:0046128 ! purine ribonucleoside metabolic process
created_by: jl
creation_date: 2014-07-31T09:21:46Z

[Term]
id: GO:1903228
name: xanthosine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of xanthosine." [GO_REF:0000068, GOC:TermGenie, PMID:7007809, PMID:7559336]
synonym: "xanthosine breakdown" EXACT [GOC:TermGenie]
synonym: "xanthosine catabolism" EXACT [GOC:TermGenie]
synonym: "xanthosine degradation" EXACT [GOC:TermGenie]
is_a: GO:0046130 ! purine ribonucleoside catabolic process
is_a: GO:1903227 ! xanthosine metabolic process
created_by: jl
creation_date: 2014-07-31T09:21:52Z

[Term]
id: GO:1903229
name: xanthosine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of xanthosine." [GO_REF:0000068, GOC:TermGenie, PMID:7007809, PMID:7559336]
synonym: "xanthosine anabolism" EXACT [GOC:TermGenie]
synonym: "xanthosine biosynthesis" EXACT [GOC:TermGenie]
synonym: "xanthosine formation" EXACT [GOC:TermGenie]
synonym: "xanthosine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046129 ! purine ribonucleoside biosynthetic process
is_a: GO:1903227 ! xanthosine metabolic process
created_by: jl
creation_date: 2014-07-31T09:21:58Z

[Term]
id: GO:1903230
name: obsolete miRNA binding involved in posttranscriptional gene silencing
namespace: molecular_function
def: "OBSOLETE. Any miRNA binding that is involved in posttranscriptional gene silencing." [GO_REF:0000061, GOC:BHF, GOC:jl, GOC:TermGenie]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "microRNA binding involved in cosuppression" RELATED [GOC:TermGenie]
synonym: "microRNA binding involved in post-transcriptional gene silencing" EXACT [GOC:TermGenie]
synonym: "microRNA binding involved in posttranscriptional gene silencing" EXACT [GOC:TermGenie]
synonym: "microRNA binding involved in PTGS" EXACT [GOC:TermGenie]
synonym: "microRNA binding involved in quelling" EXACT [GOC:TermGenie]
synonym: "miRNA binding involved in cosuppression" RELATED [GOC:TermGenie]
synonym: "miRNA binding involved in post-transcriptional gene silencing" EXACT [GOC:TermGenie]
synonym: "miRNA binding involved in posttranscriptional gene silencing" EXACT []
synonym: "miRNA binding involved in PTGS" EXACT [GOC:TermGenie]
synonym: "miRNA binding involved in quelling" EXACT [GOC:TermGenie]
is_obsolete: true
created_by: jl
creation_date: 2014-07-31T10:22:18Z

[Term]
id: GO:1903231
name: mRNA binding involved in posttranscriptional gene silencing
namespace: molecular_function
def: "Any mRNA binding that is involved in posttranscriptional gene silencing." [GO_REF:0000061, GOC:BHF, GOC:BHF_miRNA, GOC:jl, GOC:TermGenie]
synonym: "mRNA binding involved in cosuppression" RELATED [GOC:TermGenie]
synonym: "mRNA binding involved in post-transcriptional gene silencing" EXACT [GOC:TermGenie]
synonym: "mRNA binding involved in PTGS" EXACT [GOC:TermGenie]
synonym: "mRNA binding involved in quelling" EXACT [GOC:TermGenie]
is_a: GO:0003729 ! mRNA binding
intersection_of: GO:0003729 ! mRNA binding
intersection_of: part_of GO:0016441 ! posttranscriptional gene silencing
relationship: part_of GO:0016441 ! posttranscriptional gene silencing
created_by: jl
creation_date: 2014-07-31T10:30:43Z

[Term]
id: GO:1903232
name: melanosome assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a melanosome, a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored." [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22511774]
synonym: "melanosome formation" EXACT [GOC:TermGenie]
is_a: GO:0032438 ! melanosome organization
is_a: GO:0070925 ! organelle assembly
created_by: bf
creation_date: 2014-07-31T10:41:38Z

[Term]
id: GO:1903233
name: regulation of calcium ion-dependent exocytosis of neurotransmitter
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis of neurotransmitter." [GO_REF:0000058, GOC:TermGenie, PMID:16782817]
comment: An example of this is Rab3gap1 in mouse (Q80UJ7) in PMID:16782817 (IMP)
is_a: GO:2000300 ! regulation of synaptic vesicle exocytosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048791 ! calcium ion-regulated exocytosis of neurotransmitter
relationship: regulates GO:0048791 ! calcium ion-regulated exocytosis of neurotransmitter
created_by: pad
creation_date: 2014-07-31T11:54:33Z

[Term]
id: GO:1903234
name: negative regulation of calcium ion-dependent exocytosis of neurotransmitter
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion-dependent exocytosis of neurotransmitter." [GO_REF:0000058, GOC:TermGenie, PMID:16782817]
comment: An example of this is Rab3gap1 in mouse (Q80UJ7) in PMID:16782817 (IMP)
synonym: "down regulation of calcium ion-dependent exocytosis of neurotransmitter" EXACT [GOC:TermGenie]
synonym: "down-regulation of calcium ion-dependent exocytosis of neurotransmitter" EXACT [GOC:TermGenie]
synonym: "downregulation of calcium ion-dependent exocytosis of neurotransmitter" EXACT [GOC:TermGenie]
synonym: "inhibition of calcium ion-dependent exocytosis of neurotransmitter" NARROW [GOC:TermGenie]
is_a: GO:1903233 ! regulation of calcium ion-dependent exocytosis of neurotransmitter
is_a: GO:2000301 ! negative regulation of synaptic vesicle exocytosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048791 ! calcium ion-regulated exocytosis of neurotransmitter
relationship: negatively_regulates GO:0048791 ! calcium ion-regulated exocytosis of neurotransmitter
created_by: pad
creation_date: 2014-07-31T11:54:40Z

[Term]
id: GO:1903235
name: positive regulation of calcium ion-dependent exocytosis of neurotransmitter
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of calcium ion-dependent exocytosis of neurotransmitter." [GO_REF:0000058, GOC:TermGenie, PMID:16782817]
comment: An example of this is Rab3gap1 in mouse (Q80UJ7) in PMID:16782817 (IMP)
synonym: "activation of calcium ion-dependent exocytosis of neurotransmitter" NARROW [GOC:TermGenie]
synonym: "up regulation of calcium ion-dependent exocytosis of neurotransmitter" EXACT [GOC:TermGenie]
synonym: "up-regulation of calcium ion-dependent exocytosis of neurotransmitter" EXACT [GOC:TermGenie]
synonym: "upregulation of calcium ion-dependent exocytosis of neurotransmitter" EXACT [GOC:TermGenie]
is_a: GO:1903233 ! regulation of calcium ion-dependent exocytosis of neurotransmitter
is_a: GO:2000302 ! positive regulation of synaptic vesicle exocytosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048791 ! calcium ion-regulated exocytosis of neurotransmitter
relationship: positively_regulates GO:0048791 ! calcium ion-regulated exocytosis of neurotransmitter
created_by: pad
creation_date: 2014-07-31T11:54:46Z

[Term]
id: GO:1903236
name: regulation of leukocyte tethering or rolling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of leukocyte tethering or rolling." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18308860]
is_a: GO:0002691 ! regulation of cellular extravasation
is_a: GO:1904994 ! regulation of leukocyte adhesion to vascular endothelial cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050901 ! leukocyte tethering or rolling
relationship: regulates GO:0050901 ! leukocyte tethering or rolling
created_by: als
creation_date: 2014-07-31T13:07:48Z

[Term]
id: GO:1903237
name: negative regulation of leukocyte tethering or rolling
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte tethering or rolling." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18308860]
synonym: "down regulation of leukocyte tethering or rolling" EXACT [GOC:TermGenie]
synonym: "down-regulation of leukocyte tethering or rolling" EXACT [GOC:TermGenie]
synonym: "downregulation of leukocyte tethering or rolling" EXACT [GOC:TermGenie]
synonym: "inhibition of leukocyte tethering or rolling" NARROW [GOC:TermGenie]
is_a: GO:0002692 ! negative regulation of cellular extravasation
is_a: GO:1903236 ! regulation of leukocyte tethering or rolling
is_a: GO:1904995 ! negative regulation of leukocyte adhesion to vascular endothelial cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0050901 ! leukocyte tethering or rolling
relationship: negatively_regulates GO:0050901 ! leukocyte tethering or rolling
created_by: als
creation_date: 2014-07-31T13:07:55Z

[Term]
id: GO:1903238
name: positive regulation of leukocyte tethering or rolling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of leukocyte tethering or rolling." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18308860]
synonym: "activation of leukocyte tethering or rolling" NARROW [GOC:TermGenie]
synonym: "up regulation of leukocyte tethering or rolling" EXACT [GOC:TermGenie]
synonym: "up-regulation of leukocyte tethering or rolling" EXACT [GOC:TermGenie]
synonym: "upregulation of leukocyte tethering or rolling" EXACT [GOC:TermGenie]
is_a: GO:0002693 ! positive regulation of cellular extravasation
is_a: GO:1903236 ! regulation of leukocyte tethering or rolling
is_a: GO:1904996 ! positive regulation of leukocyte adhesion to vascular endothelial cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0050901 ! leukocyte tethering or rolling
relationship: positively_regulates GO:0050901 ! leukocyte tethering or rolling
created_by: als
creation_date: 2014-07-31T13:08:01Z

[Term]
id: GO:1903239
name: obsolete regulation of positive regulation of the force of heart contraction by chemical signal
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of positive regulation of the force of heart contraction by chemical signal." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17242280]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "regulation of positive regulation of the force of heart contraction by chemical signal" EXACT []
synonym: "regulation of positive regulation of the force of heart muscle contraction by chemical signal" EXACT [GOC:TermGenie]
is_obsolete: true
created_by: rl
creation_date: 2014-07-31T17:00:17Z

[Term]
id: GO:1903240
name: obsolete negative regulation of positive regulation of the force of heart contraction by chemical signal
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of positive regulation of the force of heart contraction by chemical signal." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17242280]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "down regulation of positive regulation of the force of heart contraction by chemical signal" EXACT [GOC:TermGenie]
synonym: "down regulation of positive regulation of the force of heart muscle contraction by chemical signal" EXACT [GOC:TermGenie]
synonym: "down-regulation of positive regulation of the force of heart contraction by chemical signal" EXACT [GOC:TermGenie]
synonym: "down-regulation of positive regulation of the force of heart muscle contraction by chemical signal" EXACT [GOC:TermGenie]
synonym: "downregulation of positive regulation of the force of heart contraction by chemical signal" EXACT [GOC:TermGenie]
synonym: "downregulation of positive regulation of the force of heart muscle contraction by chemical signal" EXACT [GOC:TermGenie]
synonym: "inhibition of positive regulation of the force of heart contraction by chemical signal" NARROW [GOC:TermGenie]
synonym: "inhibition of positive regulation of the force of heart muscle contraction by chemical signal" NARROW [GOC:TermGenie]
synonym: "negative regulation of positive regulation of the force of heart contraction by chemical signal" EXACT []
synonym: "negative regulation of positive regulation of the force of heart muscle contraction by chemical signal" EXACT [GOC:TermGenie]
is_obsolete: true
created_by: rl
creation_date: 2014-07-31T17:00:23Z

[Term]
id: GO:1903241
name: U2-type prespliceosome assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an U2-type prespliceosome." [GO_REF:0000079, GOC:TermGenie, PMID:12374752]
synonym: "GT-AG prespliceosome assembly" NARROW [GOC:TermGenie]
synonym: "GT-AG prespliceosome formation" NARROW [GOC:TermGenie]
synonym: "major prespliceosome assembly" EXACT [GOC:TermGenie]
synonym: "major prespliceosome formation" EXACT [GOC:TermGenie]
synonym: "mammalian U2-type spliceosomal complex A assembly" NARROW [GOC:TermGenie]
synonym: "mammalian U2-type spliceosomal complex A formation" NARROW [GOC:TermGenie]
synonym: "U2-type prespliceosome formation" EXACT [GOC:TermGenie]
synonym: "yeast U2-type spliceosomal complex B assembly" NARROW [GOC:TermGenie]
synonym: "yeast U2-type spliceosomal complex B formation" NARROW [GOC:TermGenie]
is_a: GO:0000245 ! spliceosomal complex assembly
created_by: mah
creation_date: 2014-08-01T14:33:45Z

[Term]
id: GO:1903242
name: regulation of cardiac muscle hypertrophy in response to stress
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac muscle hypertrophy in response to stress." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19287093]
is_a: GO:0010611 ! regulation of cardiac muscle hypertrophy
is_a: GO:0010612 ! regulation of cardiac muscle adaptation
is_a: GO:0080134 ! regulation of response to stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0014898 ! cardiac muscle hypertrophy in response to stress
relationship: regulates GO:0014898 ! cardiac muscle hypertrophy in response to stress
created_by: rl
creation_date: 2014-08-01T16:31:36Z

[Term]
id: GO:1903243
name: negative regulation of cardiac muscle hypertrophy in response to stress
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle hypertrophy in response to stress." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19287093]
synonym: "down regulation of cardiac muscle hypertrophy in response to stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of cardiac muscle hypertrophy in response to stress" EXACT [GOC:TermGenie]
synonym: "downregulation of cardiac muscle hypertrophy in response to stress" EXACT [GOC:TermGenie]
synonym: "inhibition of cardiac muscle hypertrophy in response to stress" NARROW [GOC:TermGenie]
is_a: GO:0010614 ! negative regulation of cardiac muscle hypertrophy
is_a: GO:0010616 ! negative regulation of cardiac muscle adaptation
is_a: GO:1903242 ! regulation of cardiac muscle hypertrophy in response to stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0014898 ! cardiac muscle hypertrophy in response to stress
relationship: negatively_regulates GO:0014898 ! cardiac muscle hypertrophy in response to stress
created_by: rl
creation_date: 2014-08-01T16:31:42Z

[Term]
id: GO:1903244
name: positive regulation of cardiac muscle hypertrophy in response to stress
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle hypertrophy in response to stress." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19287093]
synonym: "activation of cardiac muscle hypertrophy in response to stress" NARROW [GOC:TermGenie]
synonym: "up regulation of cardiac muscle hypertrophy in response to stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of cardiac muscle hypertrophy in response to stress" EXACT [GOC:TermGenie]
synonym: "upregulation of cardiac muscle hypertrophy in response to stress" EXACT [GOC:TermGenie]
is_a: GO:0010613 ! positive regulation of cardiac muscle hypertrophy
is_a: GO:0010615 ! positive regulation of cardiac muscle adaptation
is_a: GO:1903242 ! regulation of cardiac muscle hypertrophy in response to stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0014898 ! cardiac muscle hypertrophy in response to stress
relationship: positively_regulates GO:0014898 ! cardiac muscle hypertrophy in response to stress
created_by: rl
creation_date: 2014-08-01T16:31:48Z

[Term]
id: GO:1903245
name: regulation of adrenergic receptor signaling pathway involved in positive regulation of heart rate
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of adrenergic receptor signaling pathway involved in positive regulation of heart rate." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:17242280]
synonym: "regulation of activation of funny current by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "regulation of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "regulation of adrenergic receptor signalling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie]
synonym: "regulation of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie]
synonym: "regulation of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie]
synonym: "regulation of If activation by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
is_a: GO:0002027 ! regulation of heart rate
is_a: GO:0003073 ! regulation of systemic arterial blood pressure
is_a: GO:1901204 ! regulation of adrenergic receptor signaling pathway involved in heart process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0086024 ! adrenergic receptor signaling pathway involved in positive regulation of heart rate
relationship: regulates GO:0086024 ! adrenergic receptor signaling pathway involved in positive regulation of heart rate
created_by: rl
creation_date: 2014-08-04T11:53:54Z

[Term]
id: GO:1903246
name: negative regulation of adrenergic receptor signaling pathway involved in positive regulation of heart rate
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of adrenergic receptor signaling pathway involved in positive regulation of heart rate." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:17242280]
synonym: "down regulation of activation of funny current by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "down regulation of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "down regulation of adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie]
synonym: "down regulation of adrenergic receptor signalling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie]
synonym: "down regulation of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie]
synonym: "down regulation of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie]
synonym: "down regulation of If activation by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "down-regulation of activation of funny current by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "down-regulation of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "down-regulation of adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie]
synonym: "down-regulation of adrenergic receptor signalling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie]
synonym: "down-regulation of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie]
synonym: "down-regulation of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie]
synonym: "down-regulation of If activation by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "downregulation of activation of funny current by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "downregulation of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "downregulation of adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie]
synonym: "downregulation of adrenergic receptor signalling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie]
synonym: "downregulation of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie]
synonym: "downregulation of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie]
synonym: "downregulation of If activation by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "inhibition of activation of funny current by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "inhibition of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "inhibition of adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie]
synonym: "inhibition of adrenergic receptor signalling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie]
synonym: "inhibition of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie]
synonym: "inhibition of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie]
synonym: "inhibition of If activation by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of activation of funny current by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of adrenergic receptor signalling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie]
synonym: "negative regulation of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie]
synonym: "negative regulation of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie]
synonym: "negative regulation of If activation by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
is_a: GO:1901205 ! negative regulation of adrenergic receptor signaling pathway involved in heart process
is_a: GO:1903245 ! regulation of adrenergic receptor signaling pathway involved in positive regulation of heart rate
is_a: GO:1903523 ! negative regulation of blood circulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0086024 ! adrenergic receptor signaling pathway involved in positive regulation of heart rate
relationship: negatively_regulates GO:0086024 ! adrenergic receptor signaling pathway involved in positive regulation of heart rate
created_by: rl
creation_date: 2014-08-04T11:54:00Z

[Term]
id: GO:1903247
name: positive regulation of adrenergic receptor signaling pathway involved in positive regulation of heart rate
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of adrenergic receptor signaling pathway involved in positive regulation of heart rate." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:17242280]
synonym: "activation of activation of funny current by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "activation of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "activation of adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie]
synonym: "activation of adrenergic receptor signalling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie]
synonym: "activation of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie]
synonym: "activation of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie]
synonym: "activation of If activation by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "positive regulation of activation of funny current by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "positive regulation of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "positive regulation of adrenergic receptor signalling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie]
synonym: "positive regulation of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie]
synonym: "positive regulation of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie]
synonym: "positive regulation of If activation by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "up regulation of activation of funny current by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "up regulation of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "up regulation of adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie]
synonym: "up regulation of adrenergic receptor signalling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie]
synonym: "up regulation of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie]
synonym: "up regulation of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie]
synonym: "up regulation of If activation by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "up-regulation of activation of funny current by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "up-regulation of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "up-regulation of adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie]
synonym: "up-regulation of adrenergic receptor signalling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie]
synonym: "up-regulation of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie]
synonym: "up-regulation of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie]
synonym: "up-regulation of If activation by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "upregulation of activation of funny current by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "upregulation of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "upregulation of adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie]
synonym: "upregulation of adrenergic receptor signalling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie]
synonym: "upregulation of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie]
synonym: "upregulation of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie]
synonym: "upregulation of If activation by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie]
is_a: GO:1901206 ! positive regulation of adrenergic receptor signaling pathway involved in heart process
is_a: GO:1903245 ! regulation of adrenergic receptor signaling pathway involved in positive regulation of heart rate
is_a: GO:1903524 ! positive regulation of blood circulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0086024 ! adrenergic receptor signaling pathway involved in positive regulation of heart rate
relationship: positively_regulates GO:0086024 ! adrenergic receptor signaling pathway involved in positive regulation of heart rate
created_by: rl
creation_date: 2014-08-04T11:54:06Z

[Term]
id: GO:1903248
name: regulation of citrulline biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of citrulline biosynthetic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19278978]
synonym: "regulation of citrulline anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of citrulline biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of citrulline formation" EXACT [GOC:TermGenie]
synonym: "regulation of citrulline synthesis" EXACT [GOC:TermGenie]
is_a: GO:2000282 ! regulation of cellular amino acid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019240 ! citrulline biosynthetic process
relationship: regulates GO:0019240 ! citrulline biosynthetic process
created_by: rl
creation_date: 2014-08-04T15:24:34Z

[Term]
id: GO:1903249
name: negative regulation of citrulline biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of citrulline biosynthetic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19278978]
synonym: "down regulation of citrulline anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of citrulline biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of citrulline biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of citrulline formation" EXACT [GOC:TermGenie]
synonym: "down regulation of citrulline synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of citrulline anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of citrulline biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of citrulline biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of citrulline formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of citrulline synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of citrulline anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of citrulline biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of citrulline biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of citrulline formation" EXACT [GOC:TermGenie]
synonym: "downregulation of citrulline synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of citrulline anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of citrulline biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of citrulline biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of citrulline formation" NARROW [GOC:TermGenie]
synonym: "inhibition of citrulline synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of citrulline anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of citrulline biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of citrulline formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of citrulline synthesis" EXACT [GOC:TermGenie]
is_a: GO:1903248 ! regulation of citrulline biosynthetic process
is_a: GO:2000283 ! negative regulation of cellular amino acid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019240 ! citrulline biosynthetic process
relationship: negatively_regulates GO:0019240 ! citrulline biosynthetic process
created_by: rl
creation_date: 2014-08-04T15:24:46Z

[Term]
id: GO:1903250
name: positive regulation of citrulline biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of citrulline biosynthetic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19278978]
synonym: "activation of citrulline anabolism" NARROW [GOC:TermGenie]
synonym: "activation of citrulline biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of citrulline biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of citrulline formation" NARROW [GOC:TermGenie]
synonym: "activation of citrulline synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of citrulline anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of citrulline biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of citrulline formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of citrulline synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of citrulline anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of citrulline biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of citrulline biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of citrulline formation" EXACT [GOC:TermGenie]
synonym: "up regulation of citrulline synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of citrulline anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of citrulline biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of citrulline biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of citrulline formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of citrulline synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of citrulline anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of citrulline biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of citrulline biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of citrulline formation" EXACT [GOC:TermGenie]
synonym: "upregulation of citrulline synthesis" EXACT [GOC:TermGenie]
is_a: GO:1903248 ! regulation of citrulline biosynthetic process
is_a: GO:2000284 ! positive regulation of cellular amino acid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0019240 ! citrulline biosynthetic process
relationship: positively_regulates GO:0019240 ! citrulline biosynthetic process
created_by: rl
creation_date: 2014-08-04T15:24:52Z

[Term]
id: GO:1903251
name: multi-ciliated epithelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a multi-ciliated epithelial cell." [GO_REF:0000086, GOC:sp, GOC:TermGenie, PMID:22231168, PMID:24934224]
synonym: "multiciliate cell differentiation" BROAD []
is_a: GO:0030855 ! epithelial cell differentiation
created_by: tb
creation_date: 2014-08-05T19:21:21Z

[Term]
id: GO:1903252
name: hercynylcysteine sulfoxide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving hercynylcysteine sulfoxide." [GO_REF:0000068, GOC:TermGenie, PMID:24828577]
synonym: "hercynylcysteine sulfoxide metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0052701 ! cellular modified histidine metabolic process
created_by: mah
creation_date: 2014-08-06T09:13:50Z

[Term]
id: GO:1903253
name: hercynylcysteine sulfoxide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of hercynylcysteine sulfoxide." [GO_REF:0000068, GOC:TermGenie, PMID:24828577]
synonym: "hercynylcysteine sulfoxide anabolism" EXACT [GOC:TermGenie]
synonym: "hercynylcysteine sulfoxide biosynthesis" EXACT [GOC:TermGenie]
synonym: "hercynylcysteine sulfoxide formation" EXACT [GOC:TermGenie]
synonym: "hercynylcysteine sulfoxide synthesis" EXACT [GOC:TermGenie]
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:0052703 ! cellular modified histidine biosynthetic process
is_a: GO:1903252 ! hercynylcysteine sulfoxide metabolic process
created_by: mah
creation_date: 2014-08-06T09:14:00Z

[Term]
id: GO:1903254
name: hercynylselenocysteine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving hercynylselenocysteine." [GO_REF:0000068, GOC:TermGenie, PMID:24828577]
synonym: "hercynylselenocysteine metabolism" EXACT [GOC:TermGenie]
is_a: GO:0001887 ! selenium compound metabolic process
is_a: GO:0052701 ! cellular modified histidine metabolic process
created_by: mah
creation_date: 2014-08-06T09:14:08Z

[Term]
id: GO:1903255
name: hercynylselenocysteine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of hercynylselenocysteine." [GO_REF:0000068, GOC:TermGenie, PMID:24828577]
synonym: "hercynylselenocysteine anabolism" EXACT [GOC:TermGenie]
synonym: "hercynylselenocysteine biosynthesis" EXACT [GOC:TermGenie]
synonym: "hercynylselenocysteine formation" EXACT [GOC:TermGenie]
synonym: "hercynylselenocysteine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0052703 ! cellular modified histidine biosynthetic process
is_a: GO:1903254 ! hercynylselenocysteine metabolic process
created_by: mah
creation_date: 2014-08-06T09:14:16Z

[Term]
id: GO:1903256
name: selenoneine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving selenoneine." [GO_REF:0000068, GOC:TermGenie, PMID:24828577]
synonym: "L-selenoneine metabolic process" NARROW []
synonym: "selenoneine metabolism" EXACT [GOC:TermGenie]
is_a: GO:0001887 ! selenium compound metabolic process
is_a: GO:0006577 ! amino-acid betaine metabolic process
is_a: GO:0052701 ! cellular modified histidine metabolic process
created_by: mah
creation_date: 2014-08-06T09:14:24Z

[Term]
id: GO:1903257
name: selenoneine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of selenoneine." [GO_REF:0000068, GOC:TermGenie, PMID:24828577]
synonym: "L-selenoneine biosynthetic process" NARROW []
synonym: "selenoneine anabolism" EXACT [GOC:TermGenie]
synonym: "selenoneine biosynthesis" EXACT [GOC:TermGenie]
synonym: "selenoneine formation" EXACT [GOC:TermGenie]
synonym: "selenoneine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0006578 ! amino-acid betaine biosynthetic process
is_a: GO:0052703 ! cellular modified histidine biosynthetic process
is_a: GO:1903256 ! selenoneine metabolic process
created_by: mah
creation_date: 2014-08-06T09:14:33Z

[Term]
id: GO:1903258
name: sorbose import into cell
namespace: biological_process
def: "The directed movement of sorbose into a cell." [GO_REF:0000075, GOC:TermGenie, PMID:2878925]
is_a: GO:0008645 ! hexose transport
created_by: mah
creation_date: 2014-08-06T09:21:53Z

[Term]
id: GO:1903259
name: exon-exon junction complex disassembly
namespace: biological_process
def: "The disaggregation of an exon-exon junction complex into its constituent components." [GO_REF:0000079, GOC:sart, GOC:TermGenie, PMID:24967911]
synonym: "EJC disassembly" EXACT [GOC:TermGenie]
is_a: GO:0043241 ! protein complex disassembly
created_by: sart
creation_date: 2014-08-06T09:44:06Z

[Term]
id: GO:1903260
name: protein localization to mating projection tip
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a mating projection tip." [GO_REF:0000087, GOC:TermGenie, PMID:11952834]
synonym: "protein localisation in mating projection tip" EXACT [GOC:TermGenie]
synonym: "protein localisation to mating projection tip" EXACT [GOC:TermGenie]
synonym: "protein localization in mating projection tip" EXACT [GOC:TermGenie]
synonym: "protein localization to conjugation tube tip" NARROW []
synonym: "protein localization to shmoo tip" NARROW []
is_a: GO:0008104 ! protein localization
created_by: mah
creation_date: 2014-08-06T13:26:14Z

[Term]
id: GO:1903261
name: regulation of serine phosphorylation of STAT3 protein
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of serine phosphorylation of STAT3 protein." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:21704380]
is_a: GO:0033139 ! regulation of peptidyl-serine phosphorylation of STAT protein
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0033136 ! serine phosphorylation of STAT3 protein
relationship: regulates GO:0033136 ! serine phosphorylation of STAT3 protein
created_by: mr
creation_date: 2014-08-06T21:22:57Z

[Term]
id: GO:1903262
name: negative regulation of serine phosphorylation of STAT3 protein
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of serine phosphorylation of STAT3 protein." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:21704380]
synonym: "down regulation of serine phosphorylation of STAT3 protein" EXACT [GOC:TermGenie]
synonym: "down-regulation of serine phosphorylation of STAT3 protein" EXACT [GOC:TermGenie]
synonym: "downregulation of serine phosphorylation of STAT3 protein" EXACT [GOC:TermGenie]
synonym: "inhibition of serine phosphorylation of STAT3 protein" NARROW [GOC:TermGenie]
is_a: GO:0033140 ! negative regulation of peptidyl-serine phosphorylation of STAT protein
is_a: GO:1903261 ! regulation of serine phosphorylation of STAT3 protein
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0033136 ! serine phosphorylation of STAT3 protein
relationship: negatively_regulates GO:0033136 ! serine phosphorylation of STAT3 protein
created_by: mr
creation_date: 2014-08-06T21:23:05Z

[Term]
id: GO:1903263
name: positive regulation of serine phosphorylation of STAT3 protein
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of serine phosphorylation of STAT3 protein." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:21704380]
synonym: "activation of serine phosphorylation of STAT3 protein" NARROW [GOC:TermGenie]
synonym: "up regulation of serine phosphorylation of STAT3 protein" EXACT [GOC:TermGenie]
synonym: "up-regulation of serine phosphorylation of STAT3 protein" EXACT [GOC:TermGenie]
synonym: "upregulation of serine phosphorylation of STAT3 protein" EXACT [GOC:TermGenie]
is_a: GO:0033141 ! positive regulation of peptidyl-serine phosphorylation of STAT protein
is_a: GO:1903261 ! regulation of serine phosphorylation of STAT3 protein
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0033136 ! serine phosphorylation of STAT3 protein
relationship: positively_regulates GO:0033136 ! serine phosphorylation of STAT3 protein
created_by: mr
creation_date: 2014-08-06T21:23:13Z

[Term]
id: GO:1903264
name: nitrate reductase activity involved in anaerobic electron transport chain
namespace: molecular_function
def: "Any nitrate reductase activity that is involved in anaerobic electron transport chain." [GO_REF:0000061, GOC:dos, GOC:TermGenie, PMID:12910261]
synonym: "nitrate reductase (acceptor) involved in anaerobic electron transport chain" EXACT [GOC:TermGenie]
synonym: "nitrite:(acceptor) oxidoreductase involved in anaerobic electron transport chain" EXACT [GOC:TermGenie]
synonym: "nitrite:acceptor oxidoreductase involved in anaerobic electron transport chain" EXACT [GOC:TermGenie]
synonym: "respiratory nitrate reductase activity involved in anaerobic electron transport chain" NARROW [GOC:TermGenie]
is_a: GO:0008940 ! nitrate reductase activity
intersection_of: GO:0008940 ! nitrate reductase activity
intersection_of: part_of GO:0019645 ! anaerobic electron transport chain
relationship: part_of GO:0019645 ! anaerobic electron transport chain
created_by: dos
creation_date: 2014-08-07T10:07:07Z

[Term]
id: GO:1903265
name: positive regulation of tumor necrosis factor-mediated signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tumor necrosis factor-mediated signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23453807]
synonym: "activation of adipocytokine signaling pathway" RELATED [GOC:TermGenie]
synonym: "activation of TNF-alpha-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of tumor necrosis factor alpha-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of tumor necrosis factor-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of tumor necrosis factor-mediated signalling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of adipocytokine signaling pathway" RELATED [GOC:TermGenie]
synonym: "positive regulation of TNF-alpha-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of tumor necrosis factor alpha-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of tumor necrosis factor-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of adipocytokine signaling pathway" RELATED [GOC:TermGenie]
synonym: "up regulation of TNF-alpha-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "up regulation of tumor necrosis factor alpha-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "up regulation of tumor necrosis factor-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of tumor necrosis factor-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of adipocytokine signaling pathway" RELATED [GOC:TermGenie]
synonym: "up-regulation of TNF-alpha-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "up-regulation of tumor necrosis factor alpha-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "up-regulation of tumor necrosis factor-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of tumor necrosis factor-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of adipocytokine signaling pathway" RELATED [GOC:TermGenie]
synonym: "upregulation of TNF-alpha-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "upregulation of tumor necrosis factor alpha-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "upregulation of tumor necrosis factor-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of tumor necrosis factor-mediated signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway
is_a: GO:0010803 ! regulation of tumor necrosis factor-mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0033209 ! tumor necrosis factor-mediated signaling pathway
relationship: positively_regulates GO:0033209 ! tumor necrosis factor-mediated signaling pathway
created_by: bf
creation_date: 2014-08-07T10:26:59Z

[Term]
id: GO:1903266
name: regulation of ornithine catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ornithine catabolic process." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:12679340]
comment: An example of this is ARGI in Saccharomyces cerevisiae (P00812) in PMID:12679340 (inferred from direct assay).
synonym: "regulation of ornithine breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of ornithine catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of ornithine degradation" EXACT [GOC:TermGenie]
is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:0090368 ! regulation of ornithine metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006593 ! ornithine catabolic process
relationship: regulates GO:0006593 ! ornithine catabolic process
created_by: bhm
creation_date: 2014-08-08T08:29:33Z

[Term]
id: GO:1903267
name: negative regulation of ornithine catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ornithine catabolic process." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:12679340]
comment: An example of this is ARGI in Saccharomyces cerevisiae (P00812) in PMID:12679340 (inferred from direct assay).
synonym: "down regulation of ornithine breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of ornithine catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of ornithine catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of ornithine degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of ornithine breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of ornithine catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of ornithine catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of ornithine degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of ornithine breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of ornithine catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of ornithine catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of ornithine degradation" EXACT [GOC:TermGenie]
synonym: "inhibition of ornithine breakdown" NARROW [GOC:TermGenie]
synonym: "inhibition of ornithine catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of ornithine catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of ornithine degradation" NARROW [GOC:TermGenie]
synonym: "negative regulation of ornithine breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of ornithine catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of ornithine degradation" EXACT [GOC:TermGenie]
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:0045763 ! negative regulation of cellular amino acid metabolic process
is_a: GO:1903266 ! regulation of ornithine catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006593 ! ornithine catabolic process
relationship: negatively_regulates GO:0006593 ! ornithine catabolic process
created_by: bhm
creation_date: 2014-08-08T08:29:42Z

[Term]
id: GO:1903268
name: positive regulation of ornithine catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ornithine catabolic process." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:12679340]
synonym: "activation of ornithine breakdown" NARROW [GOC:TermGenie]
synonym: "activation of ornithine catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of ornithine catabolism" NARROW [GOC:TermGenie]
synonym: "activation of ornithine degradation" NARROW [GOC:TermGenie]
synonym: "positive regulation of ornithine breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of ornithine catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of ornithine degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of ornithine breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of ornithine catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of ornithine catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of ornithine degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of ornithine breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of ornithine catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of ornithine catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of ornithine degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of ornithine breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of ornithine catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of ornithine catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of ornithine degradation" EXACT [GOC:TermGenie]
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:0045764 ! positive regulation of cellular amino acid metabolic process
is_a: GO:1903266 ! regulation of ornithine catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006593 ! ornithine catabolic process
relationship: positively_regulates GO:0006593 ! ornithine catabolic process
created_by: bhm
creation_date: 2014-08-08T08:29:50Z

[Term]
id: GO:1903269
name: ornithine carbamoyltransferase inhibitor complex
namespace: cellular_component
def: "A protein complex which is capable of ornithine carbamoyltransferase inhibitor activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:12679340]
comment: An example of this is ARGI in Saccharomyces cerevisiae (P00812) in PMID:12679340 (inferred from direct assay).
synonym: "ornithine carbamoyltransferase arginase complex" NARROW []
synonym: "OTC-ARGI complex" NARROW []
is_a: GO:0043234 ! protein complex
created_by: bhm
creation_date: 2014-08-08T08:47:38Z

[Term]
id: GO:1903270
name: regulation of cytoplasmic translational elongation through polyproline stretches
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cytoplasmic translational elongation through polyproline stretches." [GO_REF:0000058, GOC:TermGenie, PMID:24923804]
is_a: GO:1900247 ! regulation of cytoplasmic translational elongation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097622 ! cytoplasmic translational elongation through polyproline stretches
relationship: regulates GO:0097622 ! cytoplasmic translational elongation through polyproline stretches
created_by: mcc
creation_date: 2014-08-08T14:53:59Z

[Term]
id: GO:1903271
name: negative regulation of cytoplasmic translational elongation through polyproline stretches
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translational elongation through polyproline stretches." [GO_REF:0000058, GOC:TermGenie, PMID:24923804]
synonym: "down regulation of cytoplasmic translational elongation through polyproline stretches" EXACT [GOC:TermGenie]
synonym: "down-regulation of cytoplasmic translational elongation through polyproline stretches" EXACT [GOC:TermGenie]
synonym: "downregulation of cytoplasmic translational elongation through polyproline stretches" EXACT [GOC:TermGenie]
synonym: "inhibition of cytoplasmic translational elongation through polyproline stretches" NARROW [GOC:TermGenie]
is_a: GO:1900248 ! negative regulation of cytoplasmic translational elongation
is_a: GO:1903270 ! regulation of cytoplasmic translational elongation through polyproline stretches
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097622 ! cytoplasmic translational elongation through polyproline stretches
relationship: negatively_regulates GO:0097622 ! cytoplasmic translational elongation through polyproline stretches
created_by: mcc
creation_date: 2014-08-08T14:54:08Z

[Term]
id: GO:1903272
name: positive regulation of cytoplasmic translational elongation through polyproline stretches
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cytoplasmic translational elongation through polyproline stretches." [GO_REF:0000058, GOC:TermGenie, PMID:24923804]
synonym: "activation of cytoplasmic translational elongation through polyproline stretches" NARROW [GOC:TermGenie]
synonym: "up regulation of cytoplasmic translational elongation through polyproline stretches" EXACT [GOC:TermGenie]
synonym: "up-regulation of cytoplasmic translational elongation through polyproline stretches" EXACT [GOC:TermGenie]
synonym: "upregulation of cytoplasmic translational elongation through polyproline stretches" EXACT [GOC:TermGenie]
is_a: GO:1900249 ! positive regulation of cytoplasmic translational elongation
is_a: GO:1903270 ! regulation of cytoplasmic translational elongation through polyproline stretches
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097622 ! cytoplasmic translational elongation through polyproline stretches
relationship: positively_regulates GO:0097622 ! cytoplasmic translational elongation through polyproline stretches
created_by: mcc
creation_date: 2014-08-08T14:54:16Z

[Term]
id: GO:1903273
name: regulation of sodium ion export
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sodium ion export." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17095720]
synonym: "regulation of sodium export" EXACT [GOC:TermGenie]
is_a: GO:1902305 ! regulation of sodium ion transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071436 ! sodium ion export
relationship: regulates GO:0071436 ! sodium ion export
created_by: rl
creation_date: 2014-08-08T17:06:46Z

[Term]
id: GO:1903274
name: negative regulation of sodium ion export
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion export." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17095720]
synonym: "down regulation of sodium export" EXACT [GOC:TermGenie]
synonym: "down regulation of sodium ion export" EXACT [GOC:TermGenie]
synonym: "down-regulation of sodium export" EXACT [GOC:TermGenie]
synonym: "down-regulation of sodium ion export" EXACT [GOC:TermGenie]
synonym: "downregulation of sodium export" EXACT [GOC:TermGenie]
synonym: "downregulation of sodium ion export" EXACT [GOC:TermGenie]
synonym: "inhibition of sodium export" NARROW [GOC:TermGenie]
synonym: "inhibition of sodium ion export" NARROW [GOC:TermGenie]
synonym: "negative regulation of sodium export" EXACT [GOC:TermGenie]
is_a: GO:1902306 ! negative regulation of sodium ion transmembrane transport
is_a: GO:1903273 ! regulation of sodium ion export
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071436 ! sodium ion export
relationship: negatively_regulates GO:0071436 ! sodium ion export
created_by: rl
creation_date: 2014-08-08T17:06:54Z

[Term]
id: GO:1903275
name: positive regulation of sodium ion export
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sodium ion export." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17095720]
synonym: "activation of sodium export" NARROW [GOC:TermGenie]
synonym: "activation of sodium ion export" NARROW [GOC:TermGenie]
synonym: "positive regulation of sodium export" EXACT [GOC:TermGenie]
synonym: "up regulation of sodium export" EXACT [GOC:TermGenie]
synonym: "up regulation of sodium ion export" EXACT [GOC:TermGenie]
synonym: "up-regulation of sodium export" EXACT [GOC:TermGenie]
synonym: "up-regulation of sodium ion export" EXACT [GOC:TermGenie]
synonym: "upregulation of sodium export" EXACT [GOC:TermGenie]
synonym: "upregulation of sodium ion export" EXACT [GOC:TermGenie]
is_a: GO:1902307 ! positive regulation of sodium ion transmembrane transport
is_a: GO:1903273 ! regulation of sodium ion export
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071436 ! sodium ion export
relationship: positively_regulates GO:0071436 ! sodium ion export
created_by: rl
creation_date: 2014-08-08T17:07:09Z

[Term]
id: GO:1903276
name: regulation of sodium ion export from cell
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sodium ion export from cell." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17095720]
is_a: GO:1903273 ! regulation of sodium ion export
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0036376 ! sodium ion export from cell
relationship: regulates GO:0036376 ! sodium ion export from cell
created_by: rl
creation_date: 2014-08-08T17:10:14Z

[Term]
id: GO:1903277
name: negative regulation of sodium ion export from cell
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion export from cell." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17095720]
synonym: "down regulation of sodium ion export from cell" EXACT [GOC:TermGenie]
synonym: "down-regulation of sodium ion export from cell" EXACT [GOC:TermGenie]
synonym: "downregulation of sodium ion export from cell" EXACT [GOC:TermGenie]
synonym: "inhibition of sodium ion export from cell" NARROW [GOC:TermGenie]
is_a: GO:1903274 ! negative regulation of sodium ion export
is_a: GO:1903276 ! regulation of sodium ion export from cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0036376 ! sodium ion export from cell
relationship: negatively_regulates GO:0036376 ! sodium ion export from cell
created_by: rl
creation_date: 2014-08-08T17:10:22Z

[Term]
id: GO:1903278
name: positive regulation of sodium ion export from cell
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sodium ion export from cell." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17095720]
synonym: "activation of sodium ion export from cell" NARROW [GOC:TermGenie]
synonym: "up regulation of sodium ion export from cell" EXACT [GOC:TermGenie]
synonym: "up-regulation of sodium ion export from cell" EXACT [GOC:TermGenie]
synonym: "upregulation of sodium ion export from cell" EXACT [GOC:TermGenie]
is_a: GO:1903275 ! positive regulation of sodium ion export
is_a: GO:1903276 ! regulation of sodium ion export from cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0036376 ! sodium ion export from cell
relationship: positively_regulates GO:0036376 ! sodium ion export from cell
created_by: rl
creation_date: 2014-08-08T17:10:30Z

[Term]
id: GO:1903279
name: regulation of calcium:sodium antiporter activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of calcium:sodium antiporter activity." [GO_REF:0000059, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:19683723]
synonym: "regulation of mitochondrial sodium/calcium ion exchange" RELATED [GOC:TermGenie]
synonym: "regulation of sodium/calcium exchanger" EXACT [GOC:TermGenie]
synonym: "regulation of sodium:calcium exchange" RELATED [GOC:TermGenie]
is_a: GO:1901019 ! regulation of calcium ion transmembrane transporter activity
is_a: GO:2000649 ! regulation of sodium ion transmembrane transporter activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0005432 ! calcium:sodium antiporter activity
relationship: regulates GO:0005432 ! calcium:sodium antiporter activity
created_by: rl
creation_date: 2014-08-11T12:53:30Z

[Term]
id: GO:1903280
name: negative regulation of calcium:sodium antiporter activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium:sodium antiporter activity." [GO_REF:0000059, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:19683723]
synonym: "down regulation of calcium:sodium antiporter activity" EXACT [GOC:TermGenie]
synonym: "down regulation of mitochondrial sodium/calcium ion exchange" RELATED [GOC:TermGenie]
synonym: "down regulation of sodium/calcium exchanger" EXACT [GOC:TermGenie]
synonym: "down regulation of sodium:calcium exchange" RELATED [GOC:TermGenie]
synonym: "down-regulation of calcium:sodium antiporter activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitochondrial sodium/calcium ion exchange" RELATED [GOC:TermGenie]
synonym: "down-regulation of sodium/calcium exchanger" EXACT [GOC:TermGenie]
synonym: "down-regulation of sodium:calcium exchange" RELATED [GOC:TermGenie]
synonym: "downregulation of calcium:sodium antiporter activity" EXACT [GOC:TermGenie]
synonym: "downregulation of mitochondrial sodium/calcium ion exchange" RELATED [GOC:TermGenie]
synonym: "downregulation of sodium/calcium exchanger" EXACT [GOC:TermGenie]
synonym: "downregulation of sodium:calcium exchange" RELATED [GOC:TermGenie]
synonym: "inhibition of calcium:sodium antiporter activity" NARROW [GOC:TermGenie]
synonym: "inhibition of mitochondrial sodium/calcium ion exchange" RELATED [GOC:TermGenie]
synonym: "inhibition of sodium/calcium exchanger" NARROW [GOC:TermGenie]
synonym: "inhibition of sodium:calcium exchange" RELATED [GOC:TermGenie]
synonym: "negative regulation of mitochondrial sodium/calcium ion exchange" RELATED [GOC:TermGenie]
synonym: "negative regulation of sodium/calcium exchanger" EXACT [GOC:TermGenie]
synonym: "negative regulation of sodium:calcium exchange" RELATED [GOC:TermGenie]
is_a: GO:1901020 ! negative regulation of calcium ion transmembrane transporter activity
is_a: GO:1903279 ! regulation of calcium:sodium antiporter activity
is_a: GO:2000650 ! negative regulation of sodium ion transmembrane transporter activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0005432 ! calcium:sodium antiporter activity
relationship: negatively_regulates GO:0005432 ! calcium:sodium antiporter activity
created_by: rl
creation_date: 2014-08-11T12:53:38Z

[Term]
id: GO:1903281
name: positive regulation of calcium:sodium antiporter activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of calcium:sodium antiporter activity." [GO_REF:0000059, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:19683723]
synonym: "activation of calcium:sodium antiporter activity" NARROW [GOC:TermGenie]
synonym: "activation of mitochondrial sodium/calcium ion exchange" RELATED [GOC:TermGenie]
synonym: "activation of sodium/calcium exchanger" NARROW [GOC:TermGenie]
synonym: "activation of sodium:calcium exchange" RELATED [GOC:TermGenie]
synonym: "positive regulation of mitochondrial sodium/calcium ion exchange" RELATED [GOC:TermGenie]
synonym: "positive regulation of sodium/calcium exchanger" EXACT [GOC:TermGenie]
synonym: "positive regulation of sodium:calcium exchange" RELATED [GOC:TermGenie]
synonym: "up regulation of calcium:sodium antiporter activity" EXACT [GOC:TermGenie]
synonym: "up regulation of mitochondrial sodium/calcium ion exchange" RELATED [GOC:TermGenie]
synonym: "up regulation of sodium/calcium exchanger" EXACT [GOC:TermGenie]
synonym: "up regulation of sodium:calcium exchange" RELATED [GOC:TermGenie]
synonym: "up-regulation of calcium:sodium antiporter activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitochondrial sodium/calcium ion exchange" RELATED [GOC:TermGenie]
synonym: "up-regulation of sodium/calcium exchanger" EXACT [GOC:TermGenie]
synonym: "up-regulation of sodium:calcium exchange" RELATED [GOC:TermGenie]
synonym: "upregulation of calcium:sodium antiporter activity" EXACT [GOC:TermGenie]
synonym: "upregulation of mitochondrial sodium/calcium ion exchange" RELATED [GOC:TermGenie]
synonym: "upregulation of sodium/calcium exchanger" EXACT [GOC:TermGenie]
synonym: "upregulation of sodium:calcium exchange" RELATED [GOC:TermGenie]
is_a: GO:1901021 ! positive regulation of calcium ion transmembrane transporter activity
is_a: GO:1903279 ! regulation of calcium:sodium antiporter activity
is_a: GO:2000651 ! positive regulation of sodium ion transmembrane transporter activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0005432 ! calcium:sodium antiporter activity
relationship: positively_regulates GO:0005432 ! calcium:sodium antiporter activity
created_by: rl
creation_date: 2014-08-11T12:53:47Z

[Term]
id: GO:1903282
name: regulation of glutathione peroxidase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glutathione peroxidase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "regulation of glutathione:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of GSH peroxidase activity" EXACT [GOC:TermGenie]
synonym: "regulation of non-selenium glutathione peroxidase activity" NARROW [GOC:TermGenie]
synonym: "regulation of reduced glutathione peroxidase activity" EXACT [GOC:TermGenie]
synonym: "regulation of selenium-glutathione peroxidase activity" EXACT [GOC:TermGenie]
is_a: GO:2000468 ! regulation of peroxidase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004602 ! glutathione peroxidase activity
relationship: regulates GO:0004602 ! glutathione peroxidase activity
created_by: bf
creation_date: 2014-08-11T13:14:13Z

[Term]
id: GO:1903283
name: negative regulation of glutathione peroxidase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glutathione peroxidase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "down regulation of glutathione peroxidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of glutathione:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of GSH peroxidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of non-selenium glutathione peroxidase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of reduced glutathione peroxidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of selenium-glutathione peroxidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of glutathione peroxidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of glutathione:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of GSH peroxidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of non-selenium glutathione peroxidase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of reduced glutathione peroxidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of selenium-glutathione peroxidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of glutathione peroxidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of glutathione:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of GSH peroxidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of non-selenium glutathione peroxidase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of reduced glutathione peroxidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of selenium-glutathione peroxidase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of glutathione peroxidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of glutathione:hydrogen-peroxide oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of GSH peroxidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of non-selenium glutathione peroxidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of reduced glutathione peroxidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of selenium-glutathione peroxidase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of glutathione:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of GSH peroxidase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of non-selenium glutathione peroxidase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of reduced glutathione peroxidase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of selenium-glutathione peroxidase activity" EXACT [GOC:TermGenie]
is_a: GO:1903282 ! regulation of glutathione peroxidase activity
is_a: GO:2000469 ! negative regulation of peroxidase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004602 ! glutathione peroxidase activity
relationship: negatively_regulates GO:0004602 ! glutathione peroxidase activity
created_by: bf
creation_date: 2014-08-11T13:14:22Z

[Term]
id: GO:1903284
name: positive regulation of glutathione peroxidase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glutathione peroxidase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23507046]
synonym: "activation of glutathione peroxidase activity" NARROW [GOC:TermGenie]
synonym: "activation of glutathione:hydrogen-peroxide oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "activation of GSH peroxidase activity" NARROW [GOC:TermGenie]
synonym: "activation of non-selenium glutathione peroxidase activity" NARROW [GOC:TermGenie]
synonym: "activation of reduced glutathione peroxidase activity" NARROW [GOC:TermGenie]
synonym: "activation of selenium-glutathione peroxidase activity" NARROW [GOC:TermGenie]
synonym: "enhancement of GPX activity" EXACT [PMID:23507046]
synonym: "positive regulation of glutathione:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of GSH peroxidase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of non-selenium glutathione peroxidase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of reduced glutathione peroxidase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of selenium-glutathione peroxidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of glutathione peroxidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of glutathione:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of GSH peroxidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of non-selenium glutathione peroxidase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of reduced glutathione peroxidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of selenium-glutathione peroxidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of glutathione peroxidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of glutathione:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of GSH peroxidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of non-selenium glutathione peroxidase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of reduced glutathione peroxidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of selenium-glutathione peroxidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of glutathione peroxidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of glutathione:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of GSH peroxidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of non-selenium glutathione peroxidase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of reduced glutathione peroxidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of selenium-glutathione peroxidase activity" EXACT [GOC:TermGenie]
is_a: GO:1903282 ! regulation of glutathione peroxidase activity
is_a: GO:2000470 ! positive regulation of peroxidase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004602 ! glutathione peroxidase activity
relationship: positively_regulates GO:0004602 ! glutathione peroxidase activity
created_by: bf
creation_date: 2014-08-11T13:14:30Z

[Term]
id: GO:1903285
name: positive regulation of hydrogen peroxide catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hydrogen peroxide catabolic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23507046]
synonym: "activation of detoxification of H2O2" RELATED [GOC:TermGenie]
synonym: "activation of detoxification of hydrogen peroxide" RELATED [GOC:TermGenie]
synonym: "activation of H2O2 catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of H2O2 scavenging" RELATED [GOC:TermGenie]
synonym: "activation of hydrogen peroxide breakdown" NARROW [GOC:TermGenie]
synonym: "activation of hydrogen peroxide catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of hydrogen peroxide catabolism" NARROW [GOC:TermGenie]
synonym: "activation of hydrogen peroxide degradation" NARROW [GOC:TermGenie]
synonym: "activation of hydrogen peroxide removal" RELATED [GOC:TermGenie]
synonym: "activation of hydrogen peroxide scavenging" RELATED [GOC:TermGenie]
synonym: "positive regulation of detoxification of H2O2" RELATED [GOC:TermGenie]
synonym: "positive regulation of detoxification of hydrogen peroxide" RELATED [GOC:TermGenie]
synonym: "positive regulation of H2O2 catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of H2O2 scavenging" RELATED [GOC:TermGenie]
synonym: "positive regulation of hydrogen peroxide breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of hydrogen peroxide catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of hydrogen peroxide degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of hydrogen peroxide removal" RELATED [GOC:TermGenie]
synonym: "positive regulation of hydrogen peroxide scavenging" RELATED [GOC:TermGenie]
synonym: "up regulation of detoxification of H2O2" RELATED [GOC:TermGenie]
synonym: "up regulation of detoxification of hydrogen peroxide" RELATED [GOC:TermGenie]
synonym: "up regulation of H2O2 catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of H2O2 scavenging" RELATED [GOC:TermGenie]
synonym: "up regulation of hydrogen peroxide breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of hydrogen peroxide catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of hydrogen peroxide catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of hydrogen peroxide degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of hydrogen peroxide removal" RELATED [GOC:TermGenie]
synonym: "up regulation of hydrogen peroxide scavenging" RELATED [GOC:TermGenie]
synonym: "up-regulation of detoxification of H2O2" RELATED [GOC:TermGenie]
synonym: "up-regulation of detoxification of hydrogen peroxide" RELATED [GOC:TermGenie]
synonym: "up-regulation of H2O2 catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of H2O2 scavenging" RELATED [GOC:TermGenie]
synonym: "up-regulation of hydrogen peroxide breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of hydrogen peroxide catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of hydrogen peroxide catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of hydrogen peroxide degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of hydrogen peroxide removal" RELATED [GOC:TermGenie]
synonym: "up-regulation of hydrogen peroxide scavenging" RELATED [GOC:TermGenie]
synonym: "upregulation of detoxification of H2O2" RELATED [GOC:TermGenie]
synonym: "upregulation of detoxification of hydrogen peroxide" RELATED [GOC:TermGenie]
synonym: "upregulation of H2O2 catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of H2O2 scavenging" RELATED [GOC:TermGenie]
synonym: "upregulation of hydrogen peroxide breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of hydrogen peroxide catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of hydrogen peroxide catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of hydrogen peroxide degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of hydrogen peroxide removal" RELATED [GOC:TermGenie]
synonym: "upregulation of hydrogen peroxide scavenging" RELATED [GOC:TermGenie]
is_a: GO:0010726 ! positive regulation of hydrogen peroxide metabolic process
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:1900409 ! positive regulation of cellular response to oxidative stress
is_a: GO:1901033 ! positive regulation of response to reactive oxygen species
is_a: GO:2000295 ! regulation of hydrogen peroxide catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042744 ! hydrogen peroxide catabolic process
relationship: positively_regulates GO:0042744 ! hydrogen peroxide catabolic process
created_by: bf
creation_date: 2014-08-11T13:28:40Z

[Term]
id: GO:1903286
name: regulation of potassium ion import
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of potassium ion import." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:10636900]
synonym: "regulation of potassium import" EXACT [GOC:TermGenie]
synonym: "regulation of potassium ion uptake" EXACT [GOC:TermGenie]
is_a: GO:1901379 ! regulation of potassium ion transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010107 ! potassium ion import
relationship: regulates GO:0010107 ! potassium ion import
created_by: rl
creation_date: 2014-08-11T14:26:16Z

[Term]
id: GO:1903287
name: negative regulation of potassium ion import
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion import." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:10636900]
synonym: "down regulation of potassium import" EXACT [GOC:TermGenie]
synonym: "down regulation of potassium ion import" EXACT [GOC:TermGenie]
synonym: "down regulation of potassium ion uptake" EXACT [GOC:TermGenie]
synonym: "down-regulation of potassium import" EXACT [GOC:TermGenie]
synonym: "down-regulation of potassium ion import" EXACT [GOC:TermGenie]
synonym: "down-regulation of potassium ion uptake" EXACT [GOC:TermGenie]
synonym: "downregulation of potassium import" EXACT [GOC:TermGenie]
synonym: "downregulation of potassium ion import" EXACT [GOC:TermGenie]
synonym: "downregulation of potassium ion uptake" EXACT [GOC:TermGenie]
synonym: "inhibition of potassium import" NARROW [GOC:TermGenie]
synonym: "inhibition of potassium ion import" NARROW [GOC:TermGenie]
synonym: "inhibition of potassium ion uptake" NARROW [GOC:TermGenie]
synonym: "negative regulation of potassium import" EXACT [GOC:TermGenie]
synonym: "negative regulation of potassium ion uptake" EXACT [GOC:TermGenie]
is_a: GO:1901380 ! negative regulation of potassium ion transmembrane transport
is_a: GO:1903286 ! regulation of potassium ion import
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010107 ! potassium ion import
relationship: negatively_regulates GO:0010107 ! potassium ion import
created_by: rl
creation_date: 2014-08-11T14:26:24Z

[Term]
id: GO:1903288
name: positive regulation of potassium ion import
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of potassium ion import." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:10636900]
synonym: "activation of potassium import" NARROW [GOC:TermGenie]
synonym: "activation of potassium ion import" NARROW [GOC:TermGenie]
synonym: "activation of potassium ion uptake" NARROW [GOC:TermGenie]
synonym: "positive regulation of potassium import" EXACT [GOC:TermGenie]
synonym: "positive regulation of potassium ion uptake" EXACT [GOC:TermGenie]
synonym: "up regulation of potassium import" EXACT [GOC:TermGenie]
synonym: "up regulation of potassium ion import" EXACT [GOC:TermGenie]
synonym: "up regulation of potassium ion uptake" EXACT [GOC:TermGenie]
synonym: "up-regulation of potassium import" EXACT [GOC:TermGenie]
synonym: "up-regulation of potassium ion import" EXACT [GOC:TermGenie]
synonym: "up-regulation of potassium ion uptake" EXACT [GOC:TermGenie]
synonym: "upregulation of potassium import" EXACT [GOC:TermGenie]
synonym: "upregulation of potassium ion import" EXACT [GOC:TermGenie]
synonym: "upregulation of potassium ion uptake" EXACT [GOC:TermGenie]
is_a: GO:1901381 ! positive regulation of potassium ion transmembrane transport
is_a: GO:1903286 ! regulation of potassium ion import
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010107 ! potassium ion import
relationship: positively_regulates GO:0010107 ! potassium ion import
created_by: rl
creation_date: 2014-08-11T14:26:32Z

[Term]
id: GO:1903289
name: obsolete regulation of ATP catabolic process
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of ATP catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:10636900]
comment: The reason for making this term obsolete is that it gets misused in cases where phosphates are simply being removed from a small molecule. We found no cases where these molecules genuinely underwent catabolism.
synonym: "regulation of ATP breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of ATP catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of ATP degradation" EXACT [GOC:TermGenie]
synonym: "regulation of ATP hydrolysis" NARROW [GOC:TermGenie]
is_obsolete: true
consider: GO:0043462
created_by: rl
creation_date: 2014-08-11T14:36:39Z

[Term]
id: GO:1903290
name: obsolete negative regulation of ATP catabolic process
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of ATP catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:10636900]
comment: The reason for making this term obsolete is that it gets misused in cases where phosphates are simply being removed from a small molecule. We found no cases where these molecules genuinely underwent catabolism.
synonym: "down regulation of ATP breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of ATP catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of ATP catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of ATP degradation" EXACT [GOC:TermGenie]
synonym: "down regulation of ATP hydrolysis" NARROW [GOC:TermGenie]
synonym: "down-regulation of ATP breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of ATP catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of ATP catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of ATP degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of ATP hydrolysis" NARROW [GOC:TermGenie]
synonym: "downregulation of ATP breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of ATP catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of ATP catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of ATP degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of ATP hydrolysis" NARROW [GOC:TermGenie]
synonym: "inhibition of ATP breakdown" NARROW [GOC:TermGenie]
synonym: "inhibition of ATP catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of ATP catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of ATP degradation" NARROW [GOC:TermGenie]
synonym: "inhibition of ATP hydrolysis" NARROW [GOC:TermGenie]
synonym: "negative regulation of ATP breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of ATP catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of ATP degradation" EXACT [GOC:TermGenie]
synonym: "negative regulation of ATP hydrolysis" NARROW [GOC:TermGenie]
is_obsolete: true
consider: GO:0032780
created_by: rl
creation_date: 2014-08-11T14:36:47Z

[Term]
id: GO:1903291
name: obsolete positive regulation of ATP catabolic process
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of ATP catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:10636900]
comment: The reason for making this term obsolete is that it gets misused in cases where phosphates are simply being removed from a small molecule. We found no cases where these molecules genuinely underwent catabolism.
synonym: "activation of ATP breakdown" NARROW [GOC:TermGenie]
synonym: "activation of ATP catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of ATP catabolism" NARROW [GOC:TermGenie]
synonym: "activation of ATP degradation" NARROW [GOC:TermGenie]
synonym: "activation of ATP hydrolysis" NARROW [GOC:TermGenie]
synonym: "positive regulation of ATP breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of ATP catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of ATP degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of ATP hydrolysis" NARROW [GOC:TermGenie]
synonym: "up regulation of ATP breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of ATP catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of ATP catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of ATP degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of ATP hydrolysis" NARROW [GOC:TermGenie]
synonym: "up-regulation of ATP breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of ATP catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of ATP catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of ATP degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of ATP hydrolysis" NARROW [GOC:TermGenie]
synonym: "upregulation of ATP breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of ATP catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of ATP catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of ATP degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of ATP hydrolysis" NARROW [GOC:TermGenie]
is_obsolete: true
consider: GO:0032781
created_by: rl
creation_date: 2014-08-11T14:36:55Z

[Term]
id: GO:1903292
name: protein localization to Golgi membrane
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a Golgi membrane." [GO_REF:0000087, GOC:TermGenie, PMID:11378902]
synonym: "protein localisation in Golgi membrane" EXACT [GOC:TermGenie]
synonym: "protein localisation to Golgi membrane" EXACT [GOC:TermGenie]
synonym: "protein localization in Golgi membrane" EXACT [GOC:TermGenie]
is_a: GO:0034067 ! protein localization to Golgi apparatus
is_a: GO:0072657 ! protein localization to membrane
created_by: mah
creation_date: 2014-08-12T14:22:31Z

[Term]
id: GO:1903293
name: phosphatase complex
namespace: cellular_component
def: "A protein complex which is capable of phosphatase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:24766807]
comment: An example of this is PTEN in human (P60484) in PMID:24766807 (inferred from direct assay).
is_a: GO:1902494 ! catalytic complex
created_by: bhm
creation_date: 2014-08-13T10:25:32Z

[Term]
id: GO:1903294
name: regulation of glutamate secretion, neurotransmission
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glutamate secretion, neurotransmission." [GO_REF:0000058, GOC:TermGenie, PMID:16782817]
comment: An example of this is Rab3gap1 in mouse (Q80UJ7) in PMID:16782817 inferred from mutant phenotype
is_a: GO:0014048 ! regulation of glutamate secretion
is_a: GO:0046928 ! regulation of neurotransmitter secretion
is_a: GO:0051966 ! regulation of synaptic transmission, glutamatergic
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061535 ! glutamate secretion, neurotransmission
relationship: regulates GO:0061535 ! glutamate secretion, neurotransmission
created_by: pad
creation_date: 2014-08-13T13:54:15Z

[Term]
id: GO:1903295
name: negative regulation of glutamate secretion, neurotransmission
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glutamate secretion, neurotransmission." [GO_REF:0000058, GOC:TermGenie, PMID:16782817]
comment: An example of this is Rab3gap1 in mouse (Q80UJ7) in PMID:16782817 inferred from mutant phenotype
synonym: "down regulation of glutamate secretion, neurotransmission" EXACT [GOC:TermGenie]
synonym: "down-regulation of glutamate secretion, neurotransmission" EXACT [GOC:TermGenie]
synonym: "downregulation of glutamate secretion, neurotransmission" EXACT [GOC:TermGenie]
synonym: "inhibition of glutamate secretion, neurotransmission" NARROW [GOC:TermGenie]
is_a: GO:0014050 ! negative regulation of glutamate secretion
is_a: GO:0046929 ! negative regulation of neurotransmitter secretion
is_a: GO:0051967 ! negative regulation of synaptic transmission, glutamatergic
is_a: GO:1903294 ! regulation of glutamate secretion, neurotransmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061535 ! glutamate secretion, neurotransmission
relationship: negatively_regulates GO:0061535 ! glutamate secretion, neurotransmission
created_by: pad
creation_date: 2014-08-13T13:54:23Z

[Term]
id: GO:1903296
name: positive regulation of glutamate secretion, neurotransmission
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glutamate secretion, where glutamate acts as a neurotransmitter." [GO_REF:0000058, GOC:TermGenie, PMID:16782817]
comment: An example of this is Rab3gap1 in mouse (Q80UJ7) in PMID:16782817 inferred from mutant phenotype
synonym: "activation of glutamate secretion, neurotransmission" NARROW [GOC:TermGenie]
synonym: "up regulation of glutamate secretion, neurotransmission" EXACT [GOC:TermGenie]
synonym: "up-regulation of glutamate secretion, neurotransmission" EXACT [GOC:TermGenie]
synonym: "upregulation of glutamate secretion, neurotransmission" EXACT [GOC:TermGenie]
is_a: GO:0001956 ! positive regulation of neurotransmitter secretion
is_a: GO:0014049 ! positive regulation of glutamate secretion
is_a: GO:0051968 ! positive regulation of synaptic transmission, glutamatergic
is_a: GO:1903294 ! regulation of glutamate secretion, neurotransmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061535 ! glutamate secretion, neurotransmission
relationship: positively_regulates GO:0061535 ! glutamate secretion, neurotransmission
created_by: pad
creation_date: 2014-08-13T13:54:31Z

[Term]
id: GO:1903297
name: regulation of hypoxia-induced intrinsic apoptotic signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hypoxia-induced intrinsic apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "regulation of hypoxia-induced apoptosis" RELATED [GOC:bf]
synonym: "regulation of hypoxic stress-induced intrinsic apoptotic signaling pathway" EXACT [GOC:bf]
synonym: "regulation of intrinsic apoptotic signaling pathway in response to hypoxia" EXACT [GOC:bf]
is_a: GO:1900037 ! regulation of cellular response to hypoxia
is_a: GO:2001242 ! regulation of intrinsic apoptotic signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990144 ! intrinsic apoptotic signaling pathway in response to hypoxia
relationship: regulates GO:1990144 ! intrinsic apoptotic signaling pathway in response to hypoxia
created_by: bf
creation_date: 2014-08-14T14:47:48Z

[Term]
id: GO:1903298
name: negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hypoxia-induced intrinsic apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24553947]
synonym: "down regulation of intrinsic apoptotic signaling pathway in response to hypoxia" EXACT [GOC:TermGenie]
synonym: "down-regulation of intrinsic apoptotic signaling pathway in response to hypoxia" EXACT [GOC:TermGenie]
synonym: "downregulation of intrinsic apoptotic signaling pathway in response to hypoxia" EXACT [GOC:TermGenie]
synonym: "inhibition of intrinsic apoptotic signaling pathway in response to hypoxia" NARROW [GOC:TermGenie]
synonym: "negative regulation of hypoxia-induced apoptosis" RELATED [GOC:bf]
synonym: "negative regulation of hypoxic stress-induced intrinsic apoptotic signaling pathway" EXACT [GOC:bf]
synonym: "negative regulation of intrinsic apoptotic signaling pathway in response to hypoxia" EXACT [GOC:bf]
synonym: "protection against hypoxia-induced apoptosis" RELATED [GOC:bf]
is_a: GO:1900038 ! negative regulation of cellular response to hypoxia
is_a: GO:1903297 ! regulation of hypoxia-induced intrinsic apoptotic signaling pathway
is_a: GO:2001243 ! negative regulation of intrinsic apoptotic signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990144 ! intrinsic apoptotic signaling pathway in response to hypoxia
relationship: negatively_regulates GO:1990144 ! intrinsic apoptotic signaling pathway in response to hypoxia
created_by: bf
creation_date: 2014-08-14T14:47:56Z

[Term]
id: GO:1903299
name: regulation of hexokinase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hexokinase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:15804508]
synonym: "regulation of ATP-dependent hexokinase activity" EXACT [GOC:TermGenie]
synonym: "regulation of ATP:D-hexose 6-phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of glucose ATP phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of hexokinase (phosphorylating)" EXACT [GOC:TermGenie]
synonym: "regulation of hexokinase D" RELATED [GOC:TermGenie]
synonym: "regulation of hexokinase type I activity" NARROW [GOC:TermGenie]
synonym: "regulation of hexokinase type II activity" NARROW [GOC:TermGenie]
synonym: "regulation of hexokinase type III activity" NARROW [GOC:TermGenie]
synonym: "regulation of hexokinase type IV" RELATED [GOC:TermGenie]
synonym: "regulation of hexokinase type IV (glucokinase) activity" NARROW [GOC:TermGenie]
synonym: "regulation of hexokinase type IV glucokinase activity" EXACT [GOC:TermGenie]
is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process
is_a: GO:0043549 ! regulation of kinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004396 ! hexokinase activity
relationship: regulates GO:0004396 ! hexokinase activity
created_by: mr
creation_date: 2014-08-15T23:17:53Z

[Term]
id: GO:1903300
name: negative regulation of hexokinase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hexokinase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:15804508]
synonym: "down regulation of ATP-dependent hexokinase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of ATP:D-hexose 6-phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of glucose ATP phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of hexokinase (phosphorylating)" EXACT [GOC:TermGenie]
synonym: "down regulation of hexokinase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of hexokinase D" RELATED [GOC:TermGenie]
synonym: "down regulation of hexokinase type I activity" NARROW [GOC:TermGenie]
synonym: "down regulation of hexokinase type II activity" NARROW [GOC:TermGenie]
synonym: "down regulation of hexokinase type III activity" NARROW [GOC:TermGenie]
synonym: "down regulation of hexokinase type IV" RELATED [GOC:TermGenie]
synonym: "down regulation of hexokinase type IV (glucokinase) activity" NARROW [GOC:TermGenie]
synonym: "down regulation of hexokinase type IV glucokinase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of ATP-dependent hexokinase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of ATP:D-hexose 6-phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of glucose ATP phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of hexokinase (phosphorylating)" EXACT [GOC:TermGenie]
synonym: "down-regulation of hexokinase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of hexokinase D" RELATED [GOC:TermGenie]
synonym: "down-regulation of hexokinase type I activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of hexokinase type II activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of hexokinase type III activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of hexokinase type IV" RELATED [GOC:TermGenie]
synonym: "down-regulation of hexokinase type IV (glucokinase) activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of hexokinase type IV glucokinase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of ATP-dependent hexokinase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of ATP:D-hexose 6-phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of glucose ATP phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of hexokinase (phosphorylating)" EXACT [GOC:TermGenie]
synonym: "downregulation of hexokinase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of hexokinase D" RELATED [GOC:TermGenie]
synonym: "downregulation of hexokinase type I activity" NARROW [GOC:TermGenie]
synonym: "downregulation of hexokinase type II activity" NARROW [GOC:TermGenie]
synonym: "downregulation of hexokinase type III activity" NARROW [GOC:TermGenie]
synonym: "downregulation of hexokinase type IV" RELATED [GOC:TermGenie]
synonym: "downregulation of hexokinase type IV (glucokinase) activity" NARROW [GOC:TermGenie]
synonym: "downregulation of hexokinase type IV glucokinase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of ATP-dependent hexokinase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of ATP:D-hexose 6-phosphotransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of glucose ATP phosphotransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of hexokinase (phosphorylating)" NARROW [GOC:TermGenie]
synonym: "inhibition of hexokinase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of hexokinase D" RELATED [GOC:TermGenie]
synonym: "inhibition of hexokinase type I activity" NARROW [GOC:TermGenie]
synonym: "inhibition of hexokinase type II activity" NARROW [GOC:TermGenie]
synonym: "inhibition of hexokinase type III activity" NARROW [GOC:TermGenie]
synonym: "inhibition of hexokinase type IV" RELATED [GOC:TermGenie]
synonym: "inhibition of hexokinase type IV (glucokinase) activity" NARROW [GOC:TermGenie]
synonym: "inhibition of hexokinase type IV glucokinase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of ATP-dependent hexokinase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of ATP:D-hexose 6-phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of glucose ATP phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of hexokinase (phosphorylating)" EXACT [GOC:TermGenie]
synonym: "negative regulation of hexokinase D" RELATED [GOC:TermGenie]
synonym: "negative regulation of hexokinase type I activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of hexokinase type II activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of hexokinase type III activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of hexokinase type IV" RELATED [GOC:TermGenie]
synonym: "negative regulation of hexokinase type IV (glucokinase) activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of hexokinase type IV glucokinase activity" EXACT [GOC:TermGenie]
is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process
is_a: GO:0033673 ! negative regulation of kinase activity
is_a: GO:1903299 ! regulation of hexokinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004396 ! hexokinase activity
relationship: negatively_regulates GO:0004396 ! hexokinase activity
created_by: mr
creation_date: 2014-08-15T23:18:01Z

[Term]
id: GO:1903301
name: positive regulation of hexokinase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hexokinase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:15804508]
synonym: "activation of ATP-dependent hexokinase activity" NARROW [GOC:TermGenie]
synonym: "activation of ATP:D-hexose 6-phosphotransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of glucose ATP phosphotransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of hexokinase (phosphorylating)" NARROW [GOC:TermGenie]
synonym: "activation of hexokinase activity" NARROW [GOC:TermGenie]
synonym: "activation of hexokinase D" RELATED [GOC:TermGenie]
synonym: "activation of hexokinase type I activity" NARROW [GOC:TermGenie]
synonym: "activation of hexokinase type II activity" NARROW [GOC:TermGenie]
synonym: "activation of hexokinase type III activity" NARROW [GOC:TermGenie]
synonym: "activation of hexokinase type IV" RELATED [GOC:TermGenie]
synonym: "activation of hexokinase type IV (glucokinase) activity" NARROW [GOC:TermGenie]
synonym: "activation of hexokinase type IV glucokinase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of ATP-dependent hexokinase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of ATP:D-hexose 6-phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of glucose ATP phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of hexokinase (phosphorylating)" EXACT [GOC:TermGenie]
synonym: "positive regulation of hexokinase D" RELATED [GOC:TermGenie]
synonym: "positive regulation of hexokinase type I activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of hexokinase type II activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of hexokinase type III activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of hexokinase type IV" RELATED [GOC:TermGenie]
synonym: "positive regulation of hexokinase type IV (glucokinase) activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of hexokinase type IV glucokinase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of ATP-dependent hexokinase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of ATP:D-hexose 6-phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of glucose ATP phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of hexokinase (phosphorylating)" EXACT [GOC:TermGenie]
synonym: "up regulation of hexokinase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of hexokinase D" RELATED [GOC:TermGenie]
synonym: "up regulation of hexokinase type I activity" NARROW [GOC:TermGenie]
synonym: "up regulation of hexokinase type II activity" NARROW [GOC:TermGenie]
synonym: "up regulation of hexokinase type III activity" NARROW [GOC:TermGenie]
synonym: "up regulation of hexokinase type IV" RELATED [GOC:TermGenie]
synonym: "up regulation of hexokinase type IV (glucokinase) activity" NARROW [GOC:TermGenie]
synonym: "up regulation of hexokinase type IV glucokinase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of ATP-dependent hexokinase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of ATP:D-hexose 6-phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of glucose ATP phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of hexokinase (phosphorylating)" EXACT [GOC:TermGenie]
synonym: "up-regulation of hexokinase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of hexokinase D" RELATED [GOC:TermGenie]
synonym: "up-regulation of hexokinase type I activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of hexokinase type II activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of hexokinase type III activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of hexokinase type IV" RELATED [GOC:TermGenie]
synonym: "up-regulation of hexokinase type IV (glucokinase) activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of hexokinase type IV glucokinase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of ATP-dependent hexokinase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of ATP:D-hexose 6-phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of glucose ATP phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of hexokinase (phosphorylating)" EXACT [GOC:TermGenie]
synonym: "upregulation of hexokinase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of hexokinase D" RELATED [GOC:TermGenie]
synonym: "upregulation of hexokinase type I activity" NARROW [GOC:TermGenie]
synonym: "upregulation of hexokinase type II activity" NARROW [GOC:TermGenie]
synonym: "upregulation of hexokinase type III activity" NARROW [GOC:TermGenie]
synonym: "upregulation of hexokinase type IV" RELATED [GOC:TermGenie]
synonym: "upregulation of hexokinase type IV (glucokinase) activity" NARROW [GOC:TermGenie]
synonym: "upregulation of hexokinase type IV glucokinase activity" EXACT [GOC:TermGenie]
is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process
is_a: GO:0033674 ! positive regulation of kinase activity
is_a: GO:1903299 ! regulation of hexokinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004396 ! hexokinase activity
relationship: positively_regulates GO:0004396 ! hexokinase activity
created_by: mr
creation_date: 2014-08-15T23:18:09Z

[Term]
id: GO:1903302
name: regulation of pyruvate kinase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pyruvate kinase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:15804508]
synonym: "regulation of ATP:pyruvate 2-O-phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of phosphoenol transphosphorylase activity" EXACT [GOC:TermGenie]
synonym: "regulation of phosphoenolpyruvate kinase activity" EXACT [GOC:TermGenie]
is_a: GO:0006110 ! regulation of glycolytic process
is_a: GO:0051338 ! regulation of transferase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004743 ! pyruvate kinase activity
relationship: regulates GO:0004743 ! pyruvate kinase activity
created_by: mr
creation_date: 2014-08-15T23:25:51Z

[Term]
id: GO:1903303
name: negative regulation of pyruvate kinase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of pyruvate kinase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:15804508]
synonym: "down regulation of ATP:pyruvate 2-O-phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphoenol transphosphorylase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphoenolpyruvate kinase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of pyruvate kinase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of ATP:pyruvate 2-O-phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphoenol transphosphorylase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphoenolpyruvate kinase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of pyruvate kinase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of ATP:pyruvate 2-O-phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphoenol transphosphorylase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphoenolpyruvate kinase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of pyruvate kinase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of ATP:pyruvate 2-O-phosphotransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of phosphoenol transphosphorylase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of phosphoenolpyruvate kinase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of pyruvate kinase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of ATP:pyruvate 2-O-phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphoenol transphosphorylase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphoenolpyruvate kinase activity" EXACT [GOC:TermGenie]
is_a: GO:0045820 ! negative regulation of glycolytic process
is_a: GO:0051348 ! negative regulation of transferase activity
is_a: GO:1903302 ! regulation of pyruvate kinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004743 ! pyruvate kinase activity
relationship: negatively_regulates GO:0004743 ! pyruvate kinase activity
created_by: mr
creation_date: 2014-08-15T23:25:58Z

[Term]
id: GO:1903304
name: positive regulation of pyruvate kinase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pyruvate kinase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:15804508]
synonym: "activation of ATP:pyruvate 2-O-phosphotransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of phosphoenol transphosphorylase activity" NARROW [GOC:TermGenie]
synonym: "activation of phosphoenolpyruvate kinase activity" NARROW [GOC:TermGenie]
synonym: "activation of pyruvate kinase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of ATP:pyruvate 2-O-phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphoenol transphosphorylase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphoenolpyruvate kinase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of ATP:pyruvate 2-O-phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphoenol transphosphorylase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphoenolpyruvate kinase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of pyruvate kinase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of ATP:pyruvate 2-O-phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphoenol transphosphorylase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphoenolpyruvate kinase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of pyruvate kinase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of ATP:pyruvate 2-O-phosphotransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphoenol transphosphorylase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphoenolpyruvate kinase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of pyruvate kinase activity" EXACT [GOC:TermGenie]
is_a: GO:0045821 ! positive regulation of glycolytic process
is_a: GO:0051347 ! positive regulation of transferase activity
is_a: GO:1903302 ! regulation of pyruvate kinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004743 ! pyruvate kinase activity
relationship: positively_regulates GO:0004743 ! pyruvate kinase activity
created_by: mr
creation_date: 2014-08-15T23:26:06Z

[Term]
id: GO:1903305
name: regulation of regulated secretory pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of regulated secretory pathway." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:12526776]
comment: An example of this is protein domain-specific expression of Synaptotagmin 1 in rat (P21707) in PMID:12526776 inferred from mutant phenotype.
is_a: GO:0017157 ! regulation of exocytosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045055 ! regulated exocytosis
relationship: regulates GO:0045055 ! regulated exocytosis
created_by: pad
creation_date: 2014-08-18T10:04:53Z

[Term]
id: GO:1903306
name: negative regulation of regulated secretory pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of regulated secretory pathway." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:12526776]
comment: An example of this is protein domain-specific expression of Synaptotagmin 1 in rat (P21707) in PMID:12526776 inferred from mutant phenotype.
synonym: "down regulation of regulated secretory pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of regulated secretory pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of regulated secretory pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of regulated secretory pathway" NARROW [GOC:TermGenie]
is_a: GO:0045920 ! negative regulation of exocytosis
is_a: GO:1903305 ! regulation of regulated secretory pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045055 ! regulated exocytosis
relationship: negatively_regulates GO:0045055 ! regulated exocytosis
created_by: pad
creation_date: 2014-08-18T10:05:02Z

[Term]
id: GO:1903307
name: positive regulation of regulated secretory pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of regulated secretory pathway." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:12526776]
comment: An example of this is protein domain-specific expression of Synaptotagmin 1 in rat (P21707) in PMID:12526776 inferred from mutant phenotype.
synonym: "activation of regulated secretory pathway" NARROW [GOC:TermGenie]
synonym: "up regulation of regulated secretory pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of regulated secretory pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of regulated secretory pathway" EXACT [GOC:TermGenie]
is_a: GO:0045921 ! positive regulation of exocytosis
is_a: GO:1903305 ! regulation of regulated secretory pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045055 ! regulated exocytosis
relationship: positively_regulates GO:0045055 ! regulated exocytosis
created_by: pad
creation_date: 2014-08-18T10:05:10Z

[Term]
id: GO:1903308
name: regulation of chromatin modification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chromatin modification." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
is_a: GO:1902275 ! regulation of chromatin organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016568 ! chromatin modification
relationship: regulates GO:0016568 ! chromatin modification
created_by: vw
creation_date: 2014-08-18T11:39:40Z

[Term]
id: GO:1903309
name: negative regulation of chromatin modification
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chromatin modification." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "down regulation of chromatin modification" EXACT [GOC:TermGenie]
synonym: "down-regulation of chromatin modification" EXACT [GOC:TermGenie]
synonym: "downregulation of chromatin modification" EXACT [GOC:TermGenie]
synonym: "inhibition of chromatin modification" NARROW [GOC:TermGenie]
is_a: GO:1903308 ! regulation of chromatin modification
is_a: GO:2001251 ! negative regulation of chromosome organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016568 ! chromatin modification
relationship: negatively_regulates GO:0016568 ! chromatin modification
created_by: vw
creation_date: 2014-08-18T11:39:48Z

[Term]
id: GO:1903310
name: positive regulation of chromatin modification
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chromatin modification." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "activation of chromatin modification" NARROW [GOC:TermGenie]
synonym: "up regulation of chromatin modification" EXACT [GOC:TermGenie]
synonym: "up-regulation of chromatin modification" EXACT [GOC:TermGenie]
synonym: "upregulation of chromatin modification" EXACT [GOC:TermGenie]
is_a: GO:1903308 ! regulation of chromatin modification
is_a: GO:2001252 ! positive regulation of chromosome organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016568 ! chromatin modification
relationship: positively_regulates GO:0016568 ! chromatin modification
created_by: vw
creation_date: 2014-08-18T11:39:56Z

[Term]
id: GO:1903311
name: regulation of mRNA metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "regulation of mRNA metabolism" EXACT [GOC:TermGenie]
is_a: GO:0051252 ! regulation of RNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016071 ! mRNA metabolic process
relationship: regulates GO:0016071 ! mRNA metabolic process
created_by: vw
creation_date: 2014-08-18T11:52:26Z

[Term]
id: GO:1903312
name: negative regulation of mRNA metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "down regulation of mRNA metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of mRNA metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of mRNA metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of mRNA metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of mRNA metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of mRNA metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of mRNA metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of mRNA metabolism" NARROW [GOC:TermGenie]
synonym: "negative regulation of mRNA metabolism" EXACT [GOC:TermGenie]
is_a: GO:0051253 ! negative regulation of RNA metabolic process
is_a: GO:1903311 ! regulation of mRNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016071 ! mRNA metabolic process
relationship: negatively_regulates GO:0016071 ! mRNA metabolic process
created_by: vw
creation_date: 2014-08-18T11:52:34Z

[Term]
id: GO:1903313
name: positive regulation of mRNA metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "activation of mRNA metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of mRNA metabolism" NARROW [GOC:TermGenie]
synonym: "positive regulation of mRNA metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of mRNA metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of mRNA metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of mRNA metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of mRNA metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of mRNA metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of mRNA metabolism" EXACT [GOC:TermGenie]
is_a: GO:0051254 ! positive regulation of RNA metabolic process
is_a: GO:1903311 ! regulation of mRNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016071 ! mRNA metabolic process
relationship: positively_regulates GO:0016071 ! mRNA metabolic process
created_by: vw
creation_date: 2014-08-18T11:52:42Z

[Term]
id: GO:1903314
name: regulation of nitrogen cycle metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nitrogen cycle metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071941 ! nitrogen cycle metabolic process
relationship: regulates GO:0071941 ! nitrogen cycle metabolic process
created_by: vw
creation_date: 2014-08-18T12:57:34Z

[Term]
id: GO:1903315
name: negative regulation of nitrogen cycle metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of nitrogen cycle metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "down regulation of nitrogen cycle metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of nitrogen cycle metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of nitrogen cycle metabolic process" EXACT [GOC:TermGenie]
synonym: "inhibition of nitrogen cycle metabolic process" NARROW [GOC:TermGenie]
is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process
is_a: GO:1903314 ! regulation of nitrogen cycle metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071941 ! nitrogen cycle metabolic process
relationship: negatively_regulates GO:0071941 ! nitrogen cycle metabolic process
created_by: vw
creation_date: 2014-08-18T12:57:42Z

[Term]
id: GO:1903316
name: positive regulation of nitrogen cycle metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of nitrogen cycle metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "activation of nitrogen cycle metabolic process" NARROW [GOC:TermGenie]
synonym: "up regulation of nitrogen cycle metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of nitrogen cycle metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of nitrogen cycle metabolic process" EXACT [GOC:TermGenie]
is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process
is_a: GO:1903314 ! regulation of nitrogen cycle metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071941 ! nitrogen cycle metabolic process
relationship: positively_regulates GO:0071941 ! nitrogen cycle metabolic process
created_by: vw
creation_date: 2014-08-18T12:57:50Z

[Term]
id: GO:1903317
name: regulation of protein maturation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein maturation." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
is_a: GO:0010468 ! regulation of gene expression
is_a: GO:0051246 ! regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051604 ! protein maturation
relationship: regulates GO:0051604 ! protein maturation
created_by: vw
creation_date: 2014-08-18T12:59:07Z

[Term]
id: GO:1903318
name: negative regulation of protein maturation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein maturation." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "down regulation of protein maturation" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein maturation" EXACT [GOC:TermGenie]
synonym: "downregulation of protein maturation" EXACT [GOC:TermGenie]
synonym: "inhibition of protein maturation" NARROW [GOC:TermGenie]
is_a: GO:0010629 ! negative regulation of gene expression
is_a: GO:0051248 ! negative regulation of protein metabolic process
is_a: GO:1903317 ! regulation of protein maturation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051604 ! protein maturation
relationship: negatively_regulates GO:0051604 ! protein maturation
created_by: vw
creation_date: 2014-08-18T12:59:15Z

[Term]
id: GO:1903319
name: positive regulation of protein maturation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein maturation." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "activation of protein maturation" NARROW [GOC:TermGenie]
synonym: "up regulation of protein maturation" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein maturation" EXACT [GOC:TermGenie]
synonym: "upregulation of protein maturation" EXACT [GOC:TermGenie]
is_a: GO:0010628 ! positive regulation of gene expression
is_a: GO:0051247 ! positive regulation of protein metabolic process
is_a: GO:1903317 ! regulation of protein maturation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051604 ! protein maturation
relationship: positively_regulates GO:0051604 ! protein maturation
created_by: vw
creation_date: 2014-08-18T12:59:23Z

[Term]
id: GO:1903320
name: regulation of protein modification by small protein conjugation or removal
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein modification by small protein conjugation or removal." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
is_a: GO:0031399 ! regulation of protein modification process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070647 ! protein modification by small protein conjugation or removal
relationship: regulates GO:0070647 ! protein modification by small protein conjugation or removal
created_by: vw
creation_date: 2014-08-18T13:01:00Z

[Term]
id: GO:1903321
name: negative regulation of protein modification by small protein conjugation or removal
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein modification by small protein conjugation or removal." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "down regulation of protein modification by small protein conjugation or removal" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein modification by small protein conjugation or removal" EXACT [GOC:TermGenie]
synonym: "downregulation of protein modification by small protein conjugation or removal" EXACT [GOC:TermGenie]
synonym: "inhibition of protein modification by small protein conjugation or removal" NARROW [GOC:TermGenie]
is_a: GO:0031400 ! negative regulation of protein modification process
is_a: GO:1903320 ! regulation of protein modification by small protein conjugation or removal
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070647 ! protein modification by small protein conjugation or removal
relationship: negatively_regulates GO:0070647 ! protein modification by small protein conjugation or removal
created_by: vw
creation_date: 2014-08-18T13:01:08Z

[Term]
id: GO:1903322
name: positive regulation of protein modification by small protein conjugation or removal
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein modification by small protein conjugation or removal." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "activation of protein modification by small protein conjugation or removal" NARROW [GOC:TermGenie]
synonym: "up regulation of protein modification by small protein conjugation or removal" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein modification by small protein conjugation or removal" EXACT [GOC:TermGenie]
synonym: "upregulation of protein modification by small protein conjugation or removal" EXACT [GOC:TermGenie]
is_a: GO:0031401 ! positive regulation of protein modification process
is_a: GO:1903320 ! regulation of protein modification by small protein conjugation or removal
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070647 ! protein modification by small protein conjugation or removal
relationship: positively_regulates GO:0070647 ! protein modification by small protein conjugation or removal
created_by: vw
creation_date: 2014-08-18T13:01:15Z

[Term]
id: GO:1903323
name: regulation of snoRNA metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of snoRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "regulation of snoRNA metabolism" EXACT [GOC:TermGenie]
is_a: GO:0051252 ! regulation of RNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016074 ! snoRNA metabolic process
relationship: regulates GO:0016074 ! snoRNA metabolic process
created_by: vw
creation_date: 2014-08-18T13:05:17Z

[Term]
id: GO:1903324
name: negative regulation of snoRNA metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of snoRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "down regulation of snoRNA metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of snoRNA metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of snoRNA metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of snoRNA metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of snoRNA metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of snoRNA metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of snoRNA metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of snoRNA metabolism" NARROW [GOC:TermGenie]
synonym: "negative regulation of snoRNA metabolism" EXACT [GOC:TermGenie]
is_a: GO:0051253 ! negative regulation of RNA metabolic process
is_a: GO:1903323 ! regulation of snoRNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016074 ! snoRNA metabolic process
relationship: negatively_regulates GO:0016074 ! snoRNA metabolic process
created_by: vw
creation_date: 2014-08-18T13:05:25Z

[Term]
id: GO:1903325
name: positive regulation of snoRNA metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of snoRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "activation of snoRNA metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of snoRNA metabolism" NARROW [GOC:TermGenie]
synonym: "positive regulation of snoRNA metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of snoRNA metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of snoRNA metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of snoRNA metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of snoRNA metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of snoRNA metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of snoRNA metabolism" EXACT [GOC:TermGenie]
is_a: GO:0051254 ! positive regulation of RNA metabolic process
is_a: GO:1903323 ! regulation of snoRNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016074 ! snoRNA metabolic process
relationship: positively_regulates GO:0016074 ! snoRNA metabolic process
created_by: vw
creation_date: 2014-08-18T13:05:33Z

[Term]
id: GO:1903326
name: regulation of tRNA metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "regulation of tRNA metabolism" EXACT [GOC:TermGenie]
is_a: GO:0051252 ! regulation of RNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006399 ! tRNA metabolic process
relationship: regulates GO:0006399 ! tRNA metabolic process
created_by: vw
creation_date: 2014-08-18T13:08:50Z

[Term]
id: GO:1903327
name: negative regulation of tRNA metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "down regulation of tRNA metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of tRNA metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of tRNA metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of tRNA metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of tRNA metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of tRNA metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of tRNA metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of tRNA metabolism" NARROW [GOC:TermGenie]
synonym: "negative regulation of tRNA metabolism" EXACT [GOC:TermGenie]
is_a: GO:0051253 ! negative regulation of RNA metabolic process
is_a: GO:1903326 ! regulation of tRNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006399 ! tRNA metabolic process
relationship: negatively_regulates GO:0006399 ! tRNA metabolic process
created_by: vw
creation_date: 2014-08-18T13:08:58Z

[Term]
id: GO:1903328
name: positive regulation of tRNA metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "activation of tRNA metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of tRNA metabolism" NARROW [GOC:TermGenie]
synonym: "positive regulation of tRNA metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of tRNA metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of tRNA metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of tRNA metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of tRNA metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of tRNA metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of tRNA metabolism" EXACT [GOC:TermGenie]
is_a: GO:0051254 ! positive regulation of RNA metabolic process
is_a: GO:1903326 ! regulation of tRNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006399 ! tRNA metabolic process
relationship: positively_regulates GO:0006399 ! tRNA metabolic process
created_by: vw
creation_date: 2014-08-18T13:09:06Z

[Term]
id: GO:1903329
name: regulation of iron-sulfur cluster assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of iron-sulfur cluster assembly." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0051128 ! regulation of cellular component organization
is_a: GO:0051193 ! regulation of cofactor metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016226 ! iron-sulfur cluster assembly
relationship: regulates GO:0016226 ! iron-sulfur cluster assembly
created_by: vw
creation_date: 2014-08-18T13:12:41Z

[Term]
id: GO:1903330
name: negative regulation of iron-sulfur cluster assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of iron-sulfur cluster assembly." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "down regulation of iron-sulfur cluster assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of iron-sulfur cluster biosynthesis" RELATED [GOC:TermGenie]
synonym: "down regulation of iron-sulphur cluster assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of iron-sulfur cluster assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of iron-sulfur cluster biosynthesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of iron-sulphur cluster assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of iron-sulfur cluster assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of iron-sulfur cluster biosynthesis" RELATED [GOC:TermGenie]
synonym: "downregulation of iron-sulphur cluster assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of iron-sulfur cluster assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of iron-sulfur cluster biosynthesis" RELATED [GOC:TermGenie]
synonym: "inhibition of iron-sulphur cluster assembly" NARROW [GOC:TermGenie]
synonym: "negative regulation of iron-sulfur cluster biosynthesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of iron-sulphur cluster assembly" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:0051195 ! negative regulation of cofactor metabolic process
is_a: GO:1903329 ! regulation of iron-sulfur cluster assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016226 ! iron-sulfur cluster assembly
relationship: negatively_regulates GO:0016226 ! iron-sulfur cluster assembly
created_by: vw
creation_date: 2014-08-18T13:12:50Z

[Term]
id: GO:1903331
name: positive regulation of iron-sulfur cluster assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of iron-sulfur cluster assembly." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "activation of iron-sulfur cluster assembly" NARROW [GOC:TermGenie]
synonym: "activation of iron-sulfur cluster biosynthesis" RELATED [GOC:TermGenie]
synonym: "activation of iron-sulphur cluster assembly" NARROW [GOC:TermGenie]
synonym: "positive regulation of iron-sulfur cluster biosynthesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of iron-sulphur cluster assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of iron-sulfur cluster assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of iron-sulfur cluster biosynthesis" RELATED [GOC:TermGenie]
synonym: "up regulation of iron-sulphur cluster assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of iron-sulfur cluster assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of iron-sulfur cluster biosynthesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of iron-sulphur cluster assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of iron-sulfur cluster assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of iron-sulfur cluster biosynthesis" RELATED [GOC:TermGenie]
synonym: "upregulation of iron-sulphur cluster assembly" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:0051194 ! positive regulation of cofactor metabolic process
is_a: GO:1903329 ! regulation of iron-sulfur cluster assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016226 ! iron-sulfur cluster assembly
relationship: positively_regulates GO:0016226 ! iron-sulfur cluster assembly
created_by: vw
creation_date: 2014-08-18T13:12:57Z

[Term]
id: GO:1903332
name: regulation of protein folding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein folding." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "regulation of alpha-tubulin folding" NARROW [GOC:TermGenie]
synonym: "regulation of beta-tubulin folding" NARROW [GOC:TermGenie]
synonym: "regulation of chaperone activity" RELATED [GOC:TermGenie]
synonym: "regulation of chaperonin ATPase activity" RELATED [GOC:TermGenie]
synonym: "regulation of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie]
synonym: "regulation of co-chaperone activity" RELATED [GOC:TermGenie]
synonym: "regulation of co-chaperonin activity" RELATED [GOC:TermGenie]
synonym: "regulation of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie]
synonym: "regulation of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie]
synonym: "regulation of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie]
is_a: GO:0032268 ! regulation of cellular protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006457 ! protein folding
relationship: regulates GO:0006457 ! protein folding
created_by: vw
creation_date: 2014-08-18T13:14:34Z

[Term]
id: GO:1903333
name: negative regulation of protein folding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein folding." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "down regulation of alpha-tubulin folding" NARROW [GOC:TermGenie]
synonym: "down regulation of beta-tubulin folding" NARROW [GOC:TermGenie]
synonym: "down regulation of chaperone activity" RELATED [GOC:TermGenie]
synonym: "down regulation of chaperonin ATPase activity" RELATED [GOC:TermGenie]
synonym: "down regulation of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie]
synonym: "down regulation of co-chaperone activity" RELATED [GOC:TermGenie]
synonym: "down regulation of co-chaperonin activity" RELATED [GOC:TermGenie]
synonym: "down regulation of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie]
synonym: "down regulation of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie]
synonym: "down regulation of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie]
synonym: "down regulation of protein folding" EXACT [GOC:TermGenie]
synonym: "down-regulation of alpha-tubulin folding" NARROW [GOC:TermGenie]
synonym: "down-regulation of beta-tubulin folding" NARROW [GOC:TermGenie]
synonym: "down-regulation of chaperone activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of chaperonin ATPase activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie]
synonym: "down-regulation of co-chaperone activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of co-chaperonin activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie]
synonym: "down-regulation of protein folding" EXACT [GOC:TermGenie]
synonym: "downregulation of alpha-tubulin folding" NARROW [GOC:TermGenie]
synonym: "downregulation of beta-tubulin folding" NARROW [GOC:TermGenie]
synonym: "downregulation of chaperone activity" RELATED [GOC:TermGenie]
synonym: "downregulation of chaperonin ATPase activity" RELATED [GOC:TermGenie]
synonym: "downregulation of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie]
synonym: "downregulation of co-chaperone activity" RELATED [GOC:TermGenie]
synonym: "downregulation of co-chaperonin activity" RELATED [GOC:TermGenie]
synonym: "downregulation of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie]
synonym: "downregulation of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie]
synonym: "downregulation of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie]
synonym: "downregulation of protein folding" EXACT [GOC:TermGenie]
synonym: "inhibition of alpha-tubulin folding" NARROW [GOC:TermGenie]
synonym: "inhibition of beta-tubulin folding" NARROW [GOC:TermGenie]
synonym: "inhibition of chaperone activity" RELATED [GOC:TermGenie]
synonym: "inhibition of chaperonin ATPase activity" RELATED [GOC:TermGenie]
synonym: "inhibition of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie]
synonym: "inhibition of co-chaperone activity" RELATED [GOC:TermGenie]
synonym: "inhibition of co-chaperonin activity" RELATED [GOC:TermGenie]
synonym: "inhibition of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie]
synonym: "inhibition of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie]
synonym: "inhibition of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie]
synonym: "inhibition of protein folding" NARROW [GOC:TermGenie]
synonym: "negative regulation of alpha-tubulin folding" NARROW [GOC:TermGenie]
synonym: "negative regulation of beta-tubulin folding" NARROW [GOC:TermGenie]
synonym: "negative regulation of chaperone activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of chaperonin ATPase activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie]
synonym: "negative regulation of co-chaperone activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of co-chaperonin activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie]
is_a: GO:0032269 ! negative regulation of cellular protein metabolic process
is_a: GO:1903332 ! regulation of protein folding
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006457 ! protein folding
relationship: negatively_regulates GO:0006457 ! protein folding
created_by: vw
creation_date: 2014-08-18T13:14:42Z

[Term]
id: GO:1903334
name: positive regulation of protein folding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein folding." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "activation of alpha-tubulin folding" NARROW [GOC:TermGenie]
synonym: "activation of beta-tubulin folding" NARROW [GOC:TermGenie]
synonym: "activation of chaperone activity" RELATED [GOC:TermGenie]
synonym: "activation of chaperonin ATPase activity" RELATED [GOC:TermGenie]
synonym: "activation of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie]
synonym: "activation of co-chaperone activity" RELATED [GOC:TermGenie]
synonym: "activation of co-chaperonin activity" RELATED [GOC:TermGenie]
synonym: "activation of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie]
synonym: "activation of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie]
synonym: "activation of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie]
synonym: "activation of protein folding" NARROW [GOC:TermGenie]
synonym: "positive regulation of alpha-tubulin folding" NARROW [GOC:TermGenie]
synonym: "positive regulation of beta-tubulin folding" NARROW [GOC:TermGenie]
synonym: "positive regulation of chaperone activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of chaperonin ATPase activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie]
synonym: "positive regulation of co-chaperone activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of co-chaperonin activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie]
synonym: "up regulation of alpha-tubulin folding" NARROW [GOC:TermGenie]
synonym: "up regulation of beta-tubulin folding" NARROW [GOC:TermGenie]
synonym: "up regulation of chaperone activity" RELATED [GOC:TermGenie]
synonym: "up regulation of chaperonin ATPase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie]
synonym: "up regulation of co-chaperone activity" RELATED [GOC:TermGenie]
synonym: "up regulation of co-chaperonin activity" RELATED [GOC:TermGenie]
synonym: "up regulation of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie]
synonym: "up regulation of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie]
synonym: "up regulation of protein folding" EXACT [GOC:TermGenie]
synonym: "up-regulation of alpha-tubulin folding" NARROW [GOC:TermGenie]
synonym: "up-regulation of beta-tubulin folding" NARROW [GOC:TermGenie]
synonym: "up-regulation of chaperone activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of chaperonin ATPase activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie]
synonym: "up-regulation of co-chaperone activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of co-chaperonin activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie]
synonym: "up-regulation of protein folding" EXACT [GOC:TermGenie]
synonym: "upregulation of alpha-tubulin folding" NARROW [GOC:TermGenie]
synonym: "upregulation of beta-tubulin folding" NARROW [GOC:TermGenie]
synonym: "upregulation of chaperone activity" RELATED [GOC:TermGenie]
synonym: "upregulation of chaperonin ATPase activity" RELATED [GOC:TermGenie]
synonym: "upregulation of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie]
synonym: "upregulation of co-chaperone activity" RELATED [GOC:TermGenie]
synonym: "upregulation of co-chaperonin activity" RELATED [GOC:TermGenie]
synonym: "upregulation of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie]
synonym: "upregulation of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie]
synonym: "upregulation of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie]
synonym: "upregulation of protein folding" EXACT [GOC:TermGenie]
is_a: GO:0032270 ! positive regulation of cellular protein metabolic process
is_a: GO:1903332 ! regulation of protein folding
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006457 ! protein folding
relationship: positively_regulates GO:0006457 ! protein folding
created_by: vw
creation_date: 2014-08-18T13:14:50Z

[Term]
id: GO:1903335
name: regulation of vacuolar transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vacuolar transport." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
is_a: GO:0032386 ! regulation of intracellular transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007034 ! vacuolar transport
relationship: regulates GO:0007034 ! vacuolar transport
created_by: vw
creation_date: 2014-08-18T13:16:04Z

[Term]
id: GO:1903336
name: negative regulation of vacuolar transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vacuolar transport." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "down regulation of vacuolar transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of vacuolar transport" EXACT [GOC:TermGenie]
synonym: "downregulation of vacuolar transport" EXACT [GOC:TermGenie]
synonym: "inhibition of vacuolar transport" NARROW [GOC:TermGenie]
is_a: GO:0032387 ! negative regulation of intracellular transport
is_a: GO:1903335 ! regulation of vacuolar transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007034 ! vacuolar transport
relationship: negatively_regulates GO:0007034 ! vacuolar transport
created_by: vw
creation_date: 2014-08-18T13:16:11Z

[Term]
id: GO:1903337
name: positive regulation of vacuolar transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vacuolar transport." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "activation of vacuolar transport" NARROW [GOC:TermGenie]
synonym: "up regulation of vacuolar transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of vacuolar transport" EXACT [GOC:TermGenie]
synonym: "upregulation of vacuolar transport" EXACT [GOC:TermGenie]
is_a: GO:0032388 ! positive regulation of intracellular transport
is_a: GO:1903335 ! regulation of vacuolar transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007034 ! vacuolar transport
relationship: positively_regulates GO:0007034 ! vacuolar transport
created_by: vw
creation_date: 2014-08-18T13:16:19Z

[Term]
id: GO:1903338
name: regulation of cell wall organization or biogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell wall organization or biogenesis." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "regulation of cell wall organisation or biogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of cell wall organization or biogenesis at cellular level" EXACT [GOC:TermGenie]
synonym: "regulation of cellular cell wall organisation or biogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of cellular cell wall organization or biogenesis" EXACT [GOC:TermGenie]
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071554 ! cell wall organization or biogenesis
relationship: regulates GO:0071554 ! cell wall organization or biogenesis
created_by: vw
creation_date: 2014-08-18T13:20:50Z

[Term]
id: GO:1903339
name: negative regulation of cell wall organization or biogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell wall organization or biogenesis." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "down regulation of cell wall organisation or biogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of cell wall organization or biogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of cell wall organization or biogenesis at cellular level" EXACT [GOC:TermGenie]
synonym: "down regulation of cellular cell wall organisation or biogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of cellular cell wall organization or biogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell wall organisation or biogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell wall organization or biogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell wall organization or biogenesis at cellular level" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular cell wall organisation or biogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular cell wall organization or biogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of cell wall organisation or biogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of cell wall organization or biogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of cell wall organization or biogenesis at cellular level" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular cell wall organisation or biogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular cell wall organization or biogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of cell wall organisation or biogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of cell wall organization or biogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of cell wall organization or biogenesis at cellular level" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular cell wall organisation or biogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular cell wall organization or biogenesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of cell wall organisation or biogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of cell wall organization or biogenesis at cellular level" EXACT [GOC:TermGenie]
synonym: "negative regulation of cellular cell wall organisation or biogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of cellular cell wall organization or biogenesis" EXACT [GOC:TermGenie]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:1903338 ! regulation of cell wall organization or biogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071554 ! cell wall organization or biogenesis
relationship: negatively_regulates GO:0071554 ! cell wall organization or biogenesis
created_by: vw
creation_date: 2014-08-18T13:20:58Z

[Term]
id: GO:1903340
name: positive regulation of cell wall organization or biogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell wall organization or biogenesis." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "activation of cell wall organisation or biogenesis" NARROW [GOC:TermGenie]
synonym: "activation of cell wall organization or biogenesis" NARROW [GOC:TermGenie]
synonym: "activation of cell wall organization or biogenesis at cellular level" NARROW [GOC:TermGenie]
synonym: "activation of cellular cell wall organisation or biogenesis" NARROW [GOC:TermGenie]
synonym: "activation of cellular cell wall organization or biogenesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of cell wall organisation or biogenesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of cell wall organization or biogenesis at cellular level" EXACT [GOC:TermGenie]
synonym: "positive regulation of cellular cell wall organisation or biogenesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of cellular cell wall organization or biogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of cell wall organisation or biogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of cell wall organization or biogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of cell wall organization or biogenesis at cellular level" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular cell wall organisation or biogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular cell wall organization or biogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell wall organisation or biogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell wall organization or biogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell wall organization or biogenesis at cellular level" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular cell wall organisation or biogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular cell wall organization or biogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of cell wall organisation or biogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of cell wall organization or biogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of cell wall organization or biogenesis at cellular level" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular cell wall organisation or biogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular cell wall organization or biogenesis" EXACT [GOC:TermGenie]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:1903338 ! regulation of cell wall organization or biogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071554 ! cell wall organization or biogenesis
relationship: positively_regulates GO:0071554 ! cell wall organization or biogenesis
created_by: vw
creation_date: 2014-08-18T13:21:06Z

[Term]
id: GO:1903341
name: regulation of meiotic DNA double-strand break formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of meiotic DNA double-strand break formation." [GO_REF:0000058, GOC:TermGenie, PMID:25103240]
is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process
is_a: GO:0060255 ! regulation of macromolecule metabolic process
is_a: GO:0060631 ! regulation of meiosis I
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042138 ! meiotic DNA double-strand break formation
relationship: regulates GO:0042138 ! meiotic DNA double-strand break formation
created_by: mcc
creation_date: 2014-08-18T21:31:54Z

[Term]
id: GO:1903342
name: negative regulation of meiotic DNA double-strand break formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of meiotic DNA double-strand break formation." [GO_REF:0000058, GOC:TermGenie, PMID:25103240]
synonym: "down regulation of meiotic DNA double-strand break formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of meiotic DNA double-strand break formation" EXACT [GOC:TermGenie]
synonym: "downregulation of meiotic DNA double-strand break formation" EXACT [GOC:TermGenie]
synonym: "inhibition of meiotic DNA double-strand break formation" NARROW [GOC:TermGenie]
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0045835 ! negative regulation of meiotic nuclear division
is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process
is_a: GO:1903341 ! regulation of meiotic DNA double-strand break formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042138 ! meiotic DNA double-strand break formation
relationship: negatively_regulates GO:0042138 ! meiotic DNA double-strand break formation
created_by: mcc
creation_date: 2014-08-18T21:32:03Z

[Term]
id: GO:1903343
name: positive regulation of meiotic DNA double-strand break formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of meiotic DNA double-strand break formation." [GO_REF:0000058, GOC:TermGenie, PMID:25103240]
synonym: "activation of meiotic DNA double-strand break formation" NARROW [GOC:TermGenie]
synonym: "up regulation of meiotic DNA double-strand break formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of meiotic DNA double-strand break formation" EXACT [GOC:TermGenie]
synonym: "upregulation of meiotic DNA double-strand break formation" EXACT [GOC:TermGenie]
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process
is_a: GO:0060903 ! positive regulation of meiosis I
is_a: GO:1903341 ! regulation of meiotic DNA double-strand break formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042138 ! meiotic DNA double-strand break formation
relationship: positively_regulates GO:0042138 ! meiotic DNA double-strand break formation
created_by: mcc
creation_date: 2014-08-18T21:32:11Z

[Term]
id: GO:1903344
name: regulation of protein polyglycylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein polyglycylation." [GO_REF:0000058, GOC:sart, GOC:TermGenie]
is_a: GO:0031399 ! regulation of protein modification process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0018094 ! protein polyglycylation
relationship: regulates GO:0018094 ! protein polyglycylation
created_by: sart
creation_date: 2014-08-19T09:32:08Z

[Term]
id: GO:1903345
name: negative regulation of protein polyglycylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein polyglycylation." [GO_REF:0000058, GOC:sart, GOC:TermGenie]
synonym: "down regulation of protein polyglycylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein polyglycylation" EXACT [GOC:TermGenie]
synonym: "downregulation of protein polyglycylation" EXACT [GOC:TermGenie]
synonym: "inhibition of protein polyglycylation" NARROW [GOC:TermGenie]
is_a: GO:0031400 ! negative regulation of protein modification process
is_a: GO:1903344 ! regulation of protein polyglycylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0018094 ! protein polyglycylation
relationship: negatively_regulates GO:0018094 ! protein polyglycylation
created_by: sart
creation_date: 2014-08-19T09:32:16Z

[Term]
id: GO:1903346
name: positive regulation of protein polyglycylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein polyglycylation." [GO_REF:0000058, GOC:sart, GOC:TermGenie, PMID:21298005]
synonym: "activation of protein polyglycylation" NARROW [GOC:TermGenie]
synonym: "up regulation of protein polyglycylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein polyglycylation" EXACT [GOC:TermGenie]
synonym: "upregulation of protein polyglycylation" EXACT [GOC:TermGenie]
is_a: GO:0031401 ! positive regulation of protein modification process
is_a: GO:1903344 ! regulation of protein polyglycylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0018094 ! protein polyglycylation
relationship: positively_regulates GO:0018094 ! protein polyglycylation
created_by: sart
creation_date: 2014-08-19T09:32:24Z

[Term]
id: GO:1903347
name: negative regulation of bicellular tight junction assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tight junction assembly." [GO_REF:0000058, GOC:jz, GOC:TermGenie, PMID:25050009]
synonym: "down regulation of tight junction assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of tight junction formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of tight junction assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of tight junction formation" EXACT [GOC:TermGenie]
synonym: "downregulation of tight junction assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of tight junction formation" EXACT [GOC:TermGenie]
synonym: "inhibition of tight junction assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of tight junction formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of tight junction formation" EXACT [GOC:TermGenie]
is_a: GO:1901889 ! negative regulation of cell junction assembly
is_a: GO:2000810 ! regulation of bicellular tight junction assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070830 ! bicellular tight junction assembly
relationship: negatively_regulates GO:0070830 ! bicellular tight junction assembly
created_by: pr
creation_date: 2014-08-19T11:02:14Z

[Term]
id: GO:1903348
name: positive regulation of bicellular tight junction assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tight junction assembly." [GO_REF:0000058, GOC:jz, GOC:TermGenie, PMID:25050009]
synonym: "activation of tight junction assembly" NARROW [GOC:TermGenie]
synonym: "activation of tight junction formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of tight junction formation" EXACT [GOC:TermGenie]
synonym: "up regulation of tight junction assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of tight junction formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of tight junction assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of tight junction formation" EXACT [GOC:TermGenie]
synonym: "upregulation of tight junction assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of tight junction formation" EXACT [GOC:TermGenie]
is_a: GO:1901890 ! positive regulation of cell junction assembly
is_a: GO:2000810 ! regulation of bicellular tight junction assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070830 ! bicellular tight junction assembly
relationship: positively_regulates GO:0070830 ! bicellular tight junction assembly
created_by: pr
creation_date: 2014-08-19T11:05:06Z

[Term]
id: GO:1903349
name: omegasome membrane
namespace: cellular_component
def: "Any membrane that is part of an omegasome." [GO_REF:0000064, GOC:mf, GOC:TermGenie, PMID:18725538, PMID:24591649]
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0098588 ! bounding membrane of organelle
relationship: part_of GO:1990462 ! omegasome
created_by: pr
creation_date: 2014-08-19T12:33:09Z

[Term]
id: GO:1903350
name: response to dopamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dopamine stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:11118945]
is_a: GO:0071869 ! response to catecholamine
created_by: mr
creation_date: 2014-08-19T19:33:26Z

[Term]
id: GO:1903351
name: cellular response to dopamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dopamine stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:11118945]
is_a: GO:0071242 ! cellular response to ammonium ion
is_a: GO:0071870 ! cellular response to catecholamine stimulus
is_a: GO:1903350 ! response to dopamine
created_by: mr
creation_date: 2014-08-19T19:33:35Z

[Term]
id: GO:1903352
name: L-ornithine transmembrane transport
namespace: biological_process
def: "The directed movement of L-ornithine across a membrane." [GO_REF:0000069, GOC:krc, GOC:TermGenie, PMID:8195186]
is_a: GO:0015822 ! ornithine transport
is_a: GO:0098655 ! cation transmembrane transport
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport
created_by: pr
creation_date: 2014-08-20T13:01:38Z

[Term]
id: GO:1903353
name: regulation of nucleus organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nucleus organization." [GO_REF:0000058, GOC:TermGenie, PMID:16943282]
synonym: "regulation of nuclear morphology" RELATED [GOC:TermGenie]
synonym: "regulation of nuclear organisation" EXACT [GOC:TermGenie]
synonym: "regulation of nuclear organization" EXACT [GOC:TermGenie]
synonym: "regulation of nuclear organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "regulation of nucleus organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0033043 ! regulation of organelle organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006997 ! nucleus organization
relationship: regulates GO:0006997 ! nucleus organization
created_by: hjd
creation_date: 2014-08-20T19:36:16Z

[Term]
id: GO:1903354
name: regulation of distal tip cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of distal tip cell migration." [GO_REF:0000058, GOC:mm2, GOC:TermGenie, PMID:24968003]
is_a: GO:0030334 ! regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097628 ! distal tip cell migration
relationship: regulates GO:0097628 ! distal tip cell migration
created_by: pr
creation_date: 2014-08-21T10:05:08Z

[Term]
id: GO:1903355
name: negative regulation of distal tip cell migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of distal tip cell migration." [GO_REF:0000058, GOC:mm2, GOC:TermGenie, PMID:24968003]
synonym: "down regulation of distal tip cell migration" EXACT [GOC:TermGenie]
synonym: "down-regulation of distal tip cell migration" EXACT [GOC:TermGenie]
synonym: "downregulation of distal tip cell migration" EXACT [GOC:TermGenie]
synonym: "inhibition of distal tip cell migration" NARROW [GOC:TermGenie]
is_a: GO:0030336 ! negative regulation of cell migration
is_a: GO:1903354 ! regulation of distal tip cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097628 ! distal tip cell migration
relationship: negatively_regulates GO:0097628 ! distal tip cell migration
created_by: pr
creation_date: 2014-08-21T10:05:17Z

[Term]
id: GO:1903356
name: positive regulation of distal tip cell migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of distal tip cell migration." [GO_REF:0000058, GOC:mm2, GOC:TermGenie, PMID:24968003]
synonym: "activation of distal tip cell migration" NARROW [GOC:TermGenie]
synonym: "up regulation of distal tip cell migration" EXACT [GOC:TermGenie]
synonym: "up-regulation of distal tip cell migration" EXACT [GOC:TermGenie]
synonym: "upregulation of distal tip cell migration" EXACT [GOC:TermGenie]
is_a: GO:0030335 ! positive regulation of cell migration
is_a: GO:1903354 ! regulation of distal tip cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097628 ! distal tip cell migration
relationship: positively_regulates GO:0097628 ! distal tip cell migration
created_by: pr
creation_date: 2014-08-21T10:05:26Z

[Term]
id: GO:1903357
name: regulation of transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript." [GO_REF:0000058, GOC:TermGenie, PMID:9092673]
is_a: GO:1901836 ! regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter
is_a: GO:2000142 ! regulation of DNA-templated transcription, initiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001180 ! transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript
relationship: regulates GO:0001180 ! transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript
created_by: mah
creation_date: 2014-08-21T10:19:32Z

[Term]
id: GO:1903358
name: regulation of Golgi organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Golgi organization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:17562788]
synonym: "regulation of Golgi organisation" EXACT [GOC:TermGenie]
synonym: "regulation of Golgi organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0033043 ! regulation of organelle organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007030 ! Golgi organization
relationship: regulates GO:0007030 ! Golgi organization
created_by: als
creation_date: 2014-08-21T10:22:22Z

[Term]
id: GO:1903359
name: lateral cortical node assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a lateral cortical node." [GO_REF:0000079, GOC:TermGenie, PMID:25009287]
synonym: "lateral cortical node formation" EXACT [GOC:TermGenie]
synonym: "Skb1-containing cortical node assembly" EXACT [GOC:TermGenie]
synonym: "Skb1-containing cortical node formation" EXACT [GOC:TermGenie]
is_a: GO:0006461 ! protein complex assembly
created_by: mah
creation_date: 2014-08-21T10:22:51Z

[Term]
id: GO:1903360
name: protein localization to lateral cortical node
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a lateral cortical node." [GO_REF:0000087, GOC:TermGenie, PMID:25009287]
synonym: "protein localisation in lateral cortical node" EXACT [GOC:TermGenie]
synonym: "protein localisation to lateral cortical node" EXACT [GOC:TermGenie]
synonym: "protein localization in lateral cortical node" EXACT [GOC:TermGenie]
is_a: GO:0072697 ! protein localization to cell cortex
created_by: mah
creation_date: 2014-08-21T10:23:00Z

[Term]
id: GO:1903361
name: protein localization to basolateral plasma membrane
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a basolateral plasma membrane." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:24785082, PMID:9425351]
synonym: "protein localisation in basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "protein localisation to basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "protein localization in basolateral plasma membrane" EXACT [GOC:TermGenie]
is_a: GO:0072659 ! protein localization to plasma membrane
created_by: kmv
creation_date: 2014-08-21T14:23:05Z

[Term]
id: GO:1903362
name: regulation of cellular protein catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular protein catabolic process." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:24785082]
synonym: "regulation of cellular protein breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of cellular protein degradation" EXACT [GOC:TermGenie]
is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:0032268 ! regulation of cellular protein metabolic process
is_a: GO:0042176 ! regulation of protein catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044257 ! cellular protein catabolic process
relationship: regulates GO:0044257 ! cellular protein catabolic process
created_by: kmv
creation_date: 2014-08-21T15:05:45Z

[Term]
id: GO:1903363
name: negative regulation of cellular protein catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular protein catabolic process." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:24785082]
synonym: "down regulation of cellular protein breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of cellular protein degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular protein breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular protein degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular protein breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular protein degradation" EXACT [GOC:TermGenie]
synonym: "inhibition of cellular protein breakdown" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular protein catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular protein catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular protein degradation" NARROW [GOC:TermGenie]
synonym: "negative regulation of cellular protein breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of cellular protein degradation" EXACT [GOC:TermGenie]
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:0032269 ! negative regulation of cellular protein metabolic process
is_a: GO:0042177 ! negative regulation of protein catabolic process
is_a: GO:1903362 ! regulation of cellular protein catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044257 ! cellular protein catabolic process
relationship: negatively_regulates GO:0044257 ! cellular protein catabolic process
created_by: kmv
creation_date: 2014-08-21T15:05:53Z

[Term]
id: GO:1903364
name: positive regulation of cellular protein catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellular protein catabolic process." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:24785082]
synonym: "activation of cellular protein breakdown" NARROW [GOC:TermGenie]
synonym: "activation of cellular protein catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of cellular protein catabolism" NARROW [GOC:TermGenie]
synonym: "activation of cellular protein degradation" NARROW [GOC:TermGenie]
synonym: "positive regulation of cellular protein breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of cellular protein degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular protein breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular protein degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular protein breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular protein degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular protein breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular protein degradation" EXACT [GOC:TermGenie]
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:0032270 ! positive regulation of cellular protein metabolic process
is_a: GO:0045732 ! positive regulation of protein catabolic process
is_a: GO:1903362 ! regulation of cellular protein catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044257 ! cellular protein catabolic process
relationship: positively_regulates GO:0044257 ! cellular protein catabolic process
created_by: kmv
creation_date: 2014-08-21T15:06:01Z

[Term]
id: GO:1903365
name: regulation of fear response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fear response." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:8677262]
synonym: "regulation of physiological fear response" EXACT [GOC:TermGenie]
is_a: GO:0051239 ! regulation of multicellular organismal process
is_a: GO:0080134 ! regulation of response to stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042596 ! fear response
relationship: regulates GO:0042596 ! fear response
created_by: mr
creation_date: 2014-08-21T23:21:36Z

[Term]
id: GO:1903366
name: negative regulation of fear response
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of fear response." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:8677262]
synonym: "down regulation of fear response" EXACT [GOC:TermGenie]
synonym: "down regulation of physiological fear response" EXACT [GOC:TermGenie]
synonym: "down-regulation of fear response" EXACT [GOC:TermGenie]
synonym: "down-regulation of physiological fear response" EXACT [GOC:TermGenie]
synonym: "downregulation of fear response" EXACT [GOC:TermGenie]
synonym: "downregulation of physiological fear response" EXACT [GOC:TermGenie]
synonym: "inhibition of fear response" NARROW [GOC:TermGenie]
synonym: "inhibition of physiological fear response" NARROW [GOC:TermGenie]
synonym: "negative regulation of physiological fear response" EXACT [GOC:TermGenie]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1903365 ! regulation of fear response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042596 ! fear response
relationship: negatively_regulates GO:0042596 ! fear response
created_by: mr
creation_date: 2014-08-21T23:21:45Z

[Term]
id: GO:1903367
name: positive regulation of fear response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of fear response." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:8677262]
synonym: "activation of fear response" NARROW [GOC:TermGenie]
synonym: "activation of physiological fear response" NARROW [GOC:TermGenie]
synonym: "positive regulation of physiological fear response" EXACT [GOC:TermGenie]
synonym: "up regulation of fear response" EXACT [GOC:TermGenie]
synonym: "up regulation of physiological fear response" EXACT [GOC:TermGenie]
synonym: "up-regulation of fear response" EXACT [GOC:TermGenie]
synonym: "up-regulation of physiological fear response" EXACT [GOC:TermGenie]
synonym: "upregulation of fear response" EXACT [GOC:TermGenie]
synonym: "upregulation of physiological fear response" EXACT [GOC:TermGenie]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1903365 ! regulation of fear response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042596 ! fear response
relationship: positively_regulates GO:0042596 ! fear response
created_by: mr
creation_date: 2014-08-21T23:21:53Z

[Term]
id: GO:1903368
name: regulation of foraging behavior
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of foraging behavior." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:8677262]
is_a: GO:0050795 ! regulation of behavior
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060756 ! foraging behavior
relationship: regulates GO:0060756 ! foraging behavior
created_by: mr
creation_date: 2014-08-22T03:03:04Z

[Term]
id: GO:1903369
name: negative regulation of foraging behavior
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of foraging behavior." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:8677262]
synonym: "down regulation of foraging behavior" EXACT [GOC:TermGenie]
synonym: "down-regulation of foraging behavior" EXACT [GOC:TermGenie]
synonym: "downregulation of foraging behavior" EXACT [GOC:TermGenie]
synonym: "inhibition of foraging behavior" NARROW [GOC:TermGenie]
is_a: GO:0048521 ! negative regulation of behavior
is_a: GO:1903368 ! regulation of foraging behavior
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060756 ! foraging behavior
relationship: negatively_regulates GO:0060756 ! foraging behavior
created_by: mr
creation_date: 2014-08-22T03:03:12Z

[Term]
id: GO:1903370
name: positive regulation of foraging behavior
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of foraging behavior." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:8677262]
synonym: "activation of foraging behavior" NARROW [GOC:TermGenie]
synonym: "up regulation of foraging behavior" EXACT [GOC:TermGenie]
synonym: "up-regulation of foraging behavior" EXACT [GOC:TermGenie]
synonym: "upregulation of foraging behavior" EXACT [GOC:TermGenie]
is_a: GO:0048520 ! positive regulation of behavior
is_a: GO:1903368 ! regulation of foraging behavior
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060756 ! foraging behavior
relationship: positively_regulates GO:0060756 ! foraging behavior
created_by: mr
creation_date: 2014-08-22T03:03:20Z

[Term]
id: GO:1903371
name: regulation of endoplasmic reticulum tubular network organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endoplasmic reticulum tubular network organization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24891604]
synonym: "regulation of endoplasmic reticulum tubular network organisation" EXACT [GOC:TermGenie]
synonym: "regulation of ER tubular network organisation" EXACT [GOC:TermGenie]
synonym: "regulation of ER tubular network organization" EXACT [GOC:TermGenie]
is_a: GO:0033043 ! regulation of organelle organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071786 ! endoplasmic reticulum tubular network organization
relationship: regulates GO:0071786 ! endoplasmic reticulum tubular network organization
created_by: als
creation_date: 2014-08-22T11:01:14Z

[Term]
id: GO:1903372
name: negative regulation of endoplasmic reticulum tubular network organization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of endoplasmic reticulum tubular network organization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24891604]
synonym: "down regulation of endoplasmic reticulum tubular network organisation" EXACT [GOC:TermGenie]
synonym: "down regulation of endoplasmic reticulum tubular network organization" EXACT [GOC:TermGenie]
synonym: "down regulation of ER tubular network organisation" EXACT [GOC:TermGenie]
synonym: "down regulation of ER tubular network organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of endoplasmic reticulum tubular network organisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of endoplasmic reticulum tubular network organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of ER tubular network organisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of ER tubular network organization" EXACT [GOC:TermGenie]
synonym: "downregulation of endoplasmic reticulum tubular network organisation" EXACT [GOC:TermGenie]
synonym: "downregulation of endoplasmic reticulum tubular network organization" EXACT [GOC:TermGenie]
synonym: "downregulation of ER tubular network organisation" EXACT [GOC:TermGenie]
synonym: "downregulation of ER tubular network organization" EXACT [GOC:TermGenie]
synonym: "inhibition of endoplasmic reticulum tubular network organisation" NARROW [GOC:TermGenie]
synonym: "inhibition of endoplasmic reticulum tubular network organization" NARROW [GOC:TermGenie]
synonym: "inhibition of ER tubular network organisation" NARROW [GOC:TermGenie]
synonym: "inhibition of ER tubular network organization" NARROW [GOC:TermGenie]
synonym: "negative regulation of endoplasmic reticulum tubular network organisation" EXACT [GOC:TermGenie]
synonym: "negative regulation of ER tubular network organisation" EXACT [GOC:TermGenie]
synonym: "negative regulation of ER tubular network organization" EXACT [GOC:TermGenie]
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:1903371 ! regulation of endoplasmic reticulum tubular network organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071786 ! endoplasmic reticulum tubular network organization
relationship: negatively_regulates GO:0071786 ! endoplasmic reticulum tubular network organization
created_by: als
creation_date: 2014-08-22T11:01:23Z

[Term]
id: GO:1903373
name: positive regulation of endoplasmic reticulum tubular network organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endoplasmic reticulum tubular network organization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24891604]
synonym: "activation of endoplasmic reticulum tubular network organisation" NARROW [GOC:TermGenie]
synonym: "activation of endoplasmic reticulum tubular network organization" NARROW [GOC:TermGenie]
synonym: "activation of ER tubular network organisation" NARROW [GOC:TermGenie]
synonym: "activation of ER tubular network organization" NARROW [GOC:TermGenie]
synonym: "positive regulation of endoplasmic reticulum tubular network organisation" EXACT [GOC:TermGenie]
synonym: "positive regulation of ER tubular network organisation" EXACT [GOC:TermGenie]
synonym: "positive regulation of ER tubular network organization" EXACT [GOC:TermGenie]
synonym: "up regulation of endoplasmic reticulum tubular network organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of endoplasmic reticulum tubular network organization" EXACT [GOC:TermGenie]
synonym: "up regulation of ER tubular network organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of ER tubular network organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of endoplasmic reticulum tubular network organisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of endoplasmic reticulum tubular network organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of ER tubular network organisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of ER tubular network organization" EXACT [GOC:TermGenie]
synonym: "upregulation of endoplasmic reticulum tubular network organisation" EXACT [GOC:TermGenie]
synonym: "upregulation of endoplasmic reticulum tubular network organization" EXACT [GOC:TermGenie]
synonym: "upregulation of ER tubular network organisation" EXACT [GOC:TermGenie]
synonym: "upregulation of ER tubular network organization" EXACT [GOC:TermGenie]
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:1903371 ! regulation of endoplasmic reticulum tubular network organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071786 ! endoplasmic reticulum tubular network organization
relationship: positively_regulates GO:0071786 ! endoplasmic reticulum tubular network organization
created_by: als
creation_date: 2014-08-22T11:01:31Z

[Term]
id: GO:1903374
name: subarachnoid space development
namespace: biological_process
def: "The process whose specific outcome is the progression of a subarachnoid space over time, from its formation to the mature structure." [GO_REF:0000094, GOC:cjm, GOC:TermGenie, Wikipedia:Subarachnoid_space]
synonym: "cavitas subarachnoidea development" RELATED [GOC:TermGenie]
synonym: "cavum subarachnoideale development" RELATED [GOC:TermGenie]
synonym: "spatium leptomeningeum development" RELATED [GOC:TermGenie]
synonym: "spatium subarachnoideum development" RELATED [GOC:TermGenie]
synonym: "subarachnoid cavity development" RELATED [GOC:TermGenie]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007420 ! brain development
created_by: pr
creation_date: 2014-08-22T12:20:56Z

[Term]
id: GO:1903375
name: facioacoustic ganglion development
namespace: biological_process
def: "The process whose specific outcome is the progression of an acoustico-facial VII-VIII ganglion complex over time, from its formation to the mature structure." [GO_REF:0000094, GOC:bf, GOC:mat, GOC:PARL, GOC:TermGenie, PMID:18356247]
synonym: "acoustico-facial VII-VIII ganglion complex development" EXACT [UBERON:0012175]
synonym: "acousticofacial ganglion development" EXACT [GOC:TermGenie]
synonym: "facio-acoustic ganglion complex VII-VIII development" EXACT [GOC:TermGenie]
synonym: "facio-acoustic ganglion development" EXACT [GOC:TermGenie]
synonym: "facio-acoustic VII-VIII ganglion complex development" EXACT [GOC:TermGenie]
is_a: GO:0061550 ! cranial ganglion development
created_by: bf
creation_date: 2014-08-26T12:40:36Z

[Term]
id: GO:1903376
name: regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of oxidative stress-induced neuron intrinsic apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "regulation of neuron apoptosis in response to oxidative stress" RELATED [GOC:TermGenie]
synonym: "regulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT []
synonym: "regulation of oxidative stress-induced neuron apoptosis" BROAD [GOC:TermGenie]
synonym: "regulation of oxidative stress-induced neuronal apoptosis" BROAD [GOC:TermGenie]
is_a: GO:0043523 ! regulation of neuron apoptotic process
is_a: GO:1902175 ! regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
is_a: GO:1903203 ! regulation of oxidative stress-induced neuron death
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0036480 ! neuron intrinsic apoptotic signaling pathway in response to oxidative stress
relationship: regulates GO:0036480 ! neuron intrinsic apoptotic signaling pathway in response to oxidative stress
created_by: bf
creation_date: 2014-08-26T13:03:13Z

[Term]
id: GO:1903377
name: negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of oxidative stress-induced neuron intrinsic apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:15790595]
synonym: "down regulation of neuron apoptosis in response to oxidative stress" RELATED [GOC:TermGenie]
synonym: "down regulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of neuron apoptosis in response to oxidative stress" RELATED [GOC:TermGenie]
synonym: "down-regulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "downregulation of neuron apoptosis in response to oxidative stress" RELATED [GOC:TermGenie]
synonym: "downregulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "inhibition of neuron apoptosis in response to oxidative stress" RELATED [GOC:TermGenie]
synonym: "inhibition of neuron intrinsic apoptotic signaling pathway in response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "negative regulation of neuron apoptosis in response to oxidative stress" RELATED [GOC:TermGenie]
synonym: "negative regulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT []
synonym: "negative regulation of oxidative stress-induced neuron apoptosis" EXACT [GOC:bf]
synonym: "neuroprotection against oxidative stress-induced apoptosis" RELATED [GOC:bf]
synonym: "protection against oxidative stress-induced neuron apoptosis" RELATED [GOC:bf]
synonym: "protection against oxidative stress-induced neuronal apoptosis" RELATED [GOC:bf]
is_a: GO:0043524 ! negative regulation of neuron apoptotic process
is_a: GO:1902176 ! negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
is_a: GO:1903204 ! negative regulation of oxidative stress-induced neuron death
is_a: GO:1903376 ! regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0036480 ! neuron intrinsic apoptotic signaling pathway in response to oxidative stress
relationship: negatively_regulates GO:0036480 ! neuron intrinsic apoptotic signaling pathway in response to oxidative stress
created_by: bf
creation_date: 2014-08-26T13:03:28Z

[Term]
id: GO:1903378
name: positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of oxidative stress-induced neuron intrinsic apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "activation of neuron apoptosis in response to oxidative stress" RELATED [GOC:TermGenie]
synonym: "activation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "positive regulation of neuron apoptosis in response to oxidative stress" RELATED [GOC:TermGenie]
synonym: "positive regulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT []
synonym: "up regulation of neuron apoptosis in response to oxidative stress" RELATED [GOC:TermGenie]
synonym: "up regulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of neuron apoptosis in response to oxidative stress" RELATED [GOC:TermGenie]
synonym: "up-regulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "upregulation of neuron apoptosis in response to oxidative stress" RELATED [GOC:TermGenie]
synonym: "upregulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:TermGenie]
is_a: GO:0043525 ! positive regulation of neuron apoptotic process
is_a: GO:1902177 ! positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
is_a: GO:1903223 ! positive regulation of oxidative stress-induced neuron death
is_a: GO:1903376 ! regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0036480 ! neuron intrinsic apoptotic signaling pathway in response to oxidative stress
relationship: positively_regulates GO:0036480 ! neuron intrinsic apoptotic signaling pathway in response to oxidative stress
created_by: bf
creation_date: 2014-08-26T13:03:36Z

[Term]
id: GO:1903379
name: regulation of mitotic chromosome condensation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitotic chromosome condensation." [GO_REF:0000058, GOC:TermGenie, PMID:9490640]
is_a: GO:0033047 ! regulation of mitotic sister chromatid segregation
is_a: GO:0060623 ! regulation of chromosome condensation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007076 ! mitotic chromosome condensation
relationship: regulates GO:0007076 ! mitotic chromosome condensation
created_by: al
creation_date: 2014-08-26T13:57:13Z

[Term]
id: GO:1903380
name: positive regulation of mitotic chromosome condensation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitotic chromosome condensation." [GO_REF:0000058, GOC:TermGenie, PMID:9490640]
synonym: "activation of mitotic chromosome condensation" NARROW [GOC:TermGenie]
synonym: "up regulation of mitotic chromosome condensation" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitotic chromosome condensation" EXACT [GOC:TermGenie]
synonym: "upregulation of mitotic chromosome condensation" EXACT [GOC:TermGenie]
is_a: GO:0045840 ! positive regulation of mitotic nuclear division
is_a: GO:0051984 ! positive regulation of chromosome segregation
is_a: GO:1903379 ! regulation of mitotic chromosome condensation
is_a: GO:2001252 ! positive regulation of chromosome organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007076 ! mitotic chromosome condensation
relationship: positively_regulates GO:0007076 ! mitotic chromosome condensation
created_by: al
creation_date: 2014-08-26T13:57:29Z

[Term]
id: GO:1903381
name: regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of an endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "regulation of endoplasmic reticulum stress-induced neuron apoptosis" BROAD [GOC:TermGenie]
synonym: "regulation of ER stress-induced neuron apoptosis" BROAD [GOC:TermGenie]
synonym: "regulation of ER stress-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "regulation of neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT []
is_a: GO:0043523 ! regulation of neuron apoptotic process
is_a: GO:1902235 ! regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0036483 ! neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
relationship: regulates GO:0036483 ! neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
created_by: bf
creation_date: 2014-08-27T08:45:29Z

[Term]
id: GO:1903382
name: negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of an endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23453807]
synonym: "down regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of ER stress-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of ER stress-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "downregulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of ER stress-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "inhibition of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of ER stress-induced neuron intrinsic apoptotic signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" NARROW [GOC:TermGenie]
synonym: "negative regulation of ER stress-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT []
is_a: GO:0043524 ! negative regulation of neuron apoptotic process
is_a: GO:1902236 ! negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
is_a: GO:1903381 ! regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0036483 ! neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
relationship: negatively_regulates GO:0036483 ! neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
created_by: bf
creation_date: 2014-08-27T08:45:38Z

[Term]
id: GO:1903383
name: regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "regulation of H2O2-induced neuron apoptosis" BROAD [GOC:bf]
synonym: "regulation of H2O2-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "regulation of hydrogen peroxide-induced neuron apoptosis" BROAD [GOC:TermGenie]
synonym: "regulation of hydrogen peroxide-induced neuronal apoptosis" BROAD [GOC:TermGenie]
synonym: "regulation of neuron apoptosis in response to hydrogen peroxide" RELATED [GOC:TermGenie]
synonym: "regulation of neuron intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie]
synonym: "regulation of neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide" EXACT []
is_a: GO:1903207 ! regulation of hydrogen peroxide-induced neuron death
is_a: GO:1903376 ! regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
is_a: GO:1903750 ! regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0036482 ! neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide
relationship: regulates GO:0036482 ! neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide
created_by: bf
creation_date: 2014-08-27T08:50:37Z

[Term]
id: GO:1903384
name: negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of a hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23261939]
synonym: "down regulation of H2O2-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of neuron apoptosis in response to hydrogen peroxide" RELATED [GOC:TermGenie]
synonym: "down regulation of neuron intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie]
synonym: "down regulation of neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide" EXACT [GOC:TermGenie]
synonym: "down-regulation of H2O2-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of neuron apoptosis in response to hydrogen peroxide" RELATED [GOC:TermGenie]
synonym: "down-regulation of neuron intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie]
synonym: "down-regulation of neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide" EXACT [GOC:TermGenie]
synonym: "downregulation of H2O2-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of neuron apoptosis in response to hydrogen peroxide" RELATED [GOC:TermGenie]
synonym: "downregulation of neuron intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie]
synonym: "downregulation of neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide" EXACT [GOC:TermGenie]
synonym: "inhibition of H2O2-induced neuron intrinsic apoptotic signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of neuron apoptosis in response to hydrogen peroxide" RELATED [GOC:TermGenie]
synonym: "inhibition of neuron intrinsic apoptotic signaling pathway in response to H2O2" NARROW [GOC:TermGenie]
synonym: "inhibition of neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide" NARROW [GOC:TermGenie]
synonym: "negative regulation of H2O2-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of neuron apoptosis in response to hydrogen peroxide" RELATED [GOC:TermGenie]
synonym: "negative regulation of neuron intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie]
synonym: "negative regulation of neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide" EXACT []
synonym: "protection against H2O2-induced neuron apoptosis" RELATED [GOC:bf]
synonym: "protection against hydrogen peroxide-induced neuron apoptosis" RELATED [GOC:bf]
is_a: GO:1903208 ! negative regulation of hydrogen peroxide-induced neuron death
is_a: GO:1903377 ! negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
is_a: GO:1903383 ! regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway
is_a: GO:1903751 ! negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0036482 ! neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide
relationship: negatively_regulates GO:0036482 ! neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide
created_by: bf
creation_date: 2014-08-27T08:50:45Z

[Term]
id: GO:1903385
name: regulation of homophilic cell adhesion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of homophilic cell adhesion." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:21724833]
is_a: GO:0030155 ! regulation of cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007156 ! homophilic cell adhesion via plasma membrane adhesion molecules
relationship: regulates GO:0007156 ! homophilic cell adhesion via plasma membrane adhesion molecules
created_by: als
creation_date: 2014-08-27T09:57:30Z

[Term]
id: GO:1903386
name: negative regulation of homophilic cell adhesion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of homophilic cell adhesion." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:21724833]
synonym: "down regulation of homophilic cell adhesion" EXACT [GOC:TermGenie]
synonym: "down-regulation of homophilic cell adhesion" EXACT [GOC:TermGenie]
synonym: "downregulation of homophilic cell adhesion" EXACT [GOC:TermGenie]
synonym: "inhibition of homophilic cell adhesion" NARROW [GOC:TermGenie]
is_a: GO:0007162 ! negative regulation of cell adhesion
is_a: GO:1903385 ! regulation of homophilic cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007156 ! homophilic cell adhesion via plasma membrane adhesion molecules
relationship: negatively_regulates GO:0007156 ! homophilic cell adhesion via plasma membrane adhesion molecules
created_by: als
creation_date: 2014-08-27T09:57:38Z

[Term]
id: GO:1903387
name: positive regulation of homophilic cell adhesion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of homophilic cell adhesion." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:21724833]
synonym: "activation of homophilic cell adhesion" NARROW [GOC:TermGenie]
synonym: "up regulation of homophilic cell adhesion" EXACT [GOC:TermGenie]
synonym: "up-regulation of homophilic cell adhesion" EXACT [GOC:TermGenie]
synonym: "upregulation of homophilic cell adhesion" EXACT [GOC:TermGenie]
is_a: GO:0045785 ! positive regulation of cell adhesion
is_a: GO:1903385 ! regulation of homophilic cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007156 ! homophilic cell adhesion via plasma membrane adhesion molecules
relationship: positively_regulates GO:0007156 ! homophilic cell adhesion via plasma membrane adhesion molecules
created_by: als
creation_date: 2014-08-27T09:57:46Z

[Term]
id: GO:1903388
name: regulation of synaptic vesicle uncoating
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synaptic vesicle uncoating." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:21563316]
synonym: "regulation of synaptic vesicle coat depolymerization" EXACT [GOC:TermGenie]
synonym: "regulation of synaptic vesicle coat protein depolymerization" EXACT [GOC:TermGenie]
is_a: GO:1900242 ! regulation of synaptic vesicle endocytosis
is_a: GO:1901879 ! regulation of protein depolymerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016191 ! synaptic vesicle uncoating
relationship: regulates GO:0016191 ! synaptic vesicle uncoating
created_by: pad
creation_date: 2014-08-27T10:02:53Z

[Term]
id: GO:1903389
name: negative regulation of synaptic vesicle uncoating
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle uncoating." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:21563316]
synonym: "down regulation of synaptic vesicle coat depolymerization" EXACT [GOC:TermGenie]
synonym: "down regulation of synaptic vesicle coat protein depolymerization" EXACT [GOC:TermGenie]
synonym: "down regulation of synaptic vesicle uncoating" EXACT [GOC:TermGenie]
synonym: "down-regulation of synaptic vesicle coat depolymerization" EXACT [GOC:TermGenie]
synonym: "down-regulation of synaptic vesicle coat protein depolymerization" EXACT [GOC:TermGenie]
synonym: "down-regulation of synaptic vesicle uncoating" EXACT [GOC:TermGenie]
synonym: "downregulation of synaptic vesicle coat depolymerization" EXACT [GOC:TermGenie]
synonym: "downregulation of synaptic vesicle coat protein depolymerization" EXACT [GOC:TermGenie]
synonym: "downregulation of synaptic vesicle uncoating" EXACT [GOC:TermGenie]
synonym: "inhibition of synaptic vesicle coat depolymerization" NARROW [GOC:TermGenie]
synonym: "inhibition of synaptic vesicle coat protein depolymerization" NARROW [GOC:TermGenie]
synonym: "inhibition of synaptic vesicle uncoating" NARROW [GOC:TermGenie]
synonym: "negative regulation of synaptic vesicle coat depolymerization" EXACT [GOC:TermGenie]
synonym: "negative regulation of synaptic vesicle coat protein depolymerization" EXACT [GOC:TermGenie]
is_a: GO:1900243 ! negative regulation of synaptic vesicle endocytosis
is_a: GO:1901880 ! negative regulation of protein depolymerization
is_a: GO:1903388 ! regulation of synaptic vesicle uncoating
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016191 ! synaptic vesicle uncoating
relationship: negatively_regulates GO:0016191 ! synaptic vesicle uncoating
created_by: pad
creation_date: 2014-08-27T10:03:02Z

[Term]
id: GO:1903390
name: positive regulation of synaptic vesicle uncoating
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of synaptic vesicle uncoating." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:21563316]
synonym: "activation of synaptic vesicle coat depolymerization" NARROW [GOC:TermGenie]
synonym: "activation of synaptic vesicle coat protein depolymerization" NARROW [GOC:TermGenie]
synonym: "activation of synaptic vesicle uncoating" NARROW [GOC:TermGenie]
synonym: "positive regulation of synaptic vesicle coat depolymerization" EXACT [GOC:TermGenie]
synonym: "positive regulation of synaptic vesicle coat protein depolymerization" EXACT [GOC:TermGenie]
synonym: "up regulation of synaptic vesicle coat depolymerization" EXACT [GOC:TermGenie]
synonym: "up regulation of synaptic vesicle coat protein depolymerization" EXACT [GOC:TermGenie]
synonym: "up regulation of synaptic vesicle uncoating" EXACT [GOC:TermGenie]
synonym: "up-regulation of synaptic vesicle coat depolymerization" EXACT [GOC:TermGenie]
synonym: "up-regulation of synaptic vesicle coat protein depolymerization" EXACT [GOC:TermGenie]
synonym: "up-regulation of synaptic vesicle uncoating" EXACT [GOC:TermGenie]
synonym: "upregulation of synaptic vesicle coat depolymerization" EXACT [GOC:TermGenie]
synonym: "upregulation of synaptic vesicle coat protein depolymerization" EXACT [GOC:TermGenie]
synonym: "upregulation of synaptic vesicle uncoating" EXACT [GOC:TermGenie]
is_a: GO:1900244 ! positive regulation of synaptic vesicle endocytosis
is_a: GO:1901881 ! positive regulation of protein depolymerization
is_a: GO:1903388 ! regulation of synaptic vesicle uncoating
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016191 ! synaptic vesicle uncoating
relationship: positively_regulates GO:0016191 ! synaptic vesicle uncoating
created_by: pad
creation_date: 2014-08-27T10:03:10Z

[Term]
id: GO:1903391
name: regulation of adherens junction organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of adherens junction organization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:21724833]
synonym: "regulation of adherens junction assembly and maintenance" EXACT [GOC:TermGenie]
synonym: "regulation of adherens junction organisation" EXACT [GOC:TermGenie]
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034332 ! adherens junction organization
relationship: regulates GO:0034332 ! adherens junction organization
created_by: als
creation_date: 2014-08-27T10:08:38Z

[Term]
id: GO:1903392
name: negative regulation of adherens junction organization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of adherens junction organization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:21724833]
synonym: "down regulation of adherens junction assembly and maintenance" EXACT [GOC:TermGenie]
synonym: "down regulation of adherens junction organisation" EXACT [GOC:TermGenie]
synonym: "down regulation of adherens junction organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of adherens junction assembly and maintenance" EXACT [GOC:TermGenie]
synonym: "down-regulation of adherens junction organisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of adherens junction organization" EXACT [GOC:TermGenie]
synonym: "downregulation of adherens junction assembly and maintenance" EXACT [GOC:TermGenie]
synonym: "downregulation of adherens junction organisation" EXACT [GOC:TermGenie]
synonym: "downregulation of adherens junction organization" EXACT [GOC:TermGenie]
synonym: "inhibition of adherens junction assembly and maintenance" NARROW [GOC:TermGenie]
synonym: "inhibition of adherens junction organisation" NARROW [GOC:TermGenie]
synonym: "inhibition of adherens junction organization" NARROW [GOC:TermGenie]
synonym: "negative regulation of adherens junction assembly and maintenance" EXACT [GOC:TermGenie]
synonym: "negative regulation of adherens junction organisation" EXACT [GOC:TermGenie]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1903391 ! regulation of adherens junction organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034332 ! adherens junction organization
relationship: negatively_regulates GO:0034332 ! adherens junction organization
created_by: als
creation_date: 2014-08-27T10:08:47Z

[Term]
id: GO:1903393
name: positive regulation of adherens junction organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of adherens junction organization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:21724833]
synonym: "activation of adherens junction assembly and maintenance" NARROW [GOC:TermGenie]
synonym: "activation of adherens junction organisation" NARROW [GOC:TermGenie]
synonym: "activation of adherens junction organization" NARROW [GOC:TermGenie]
synonym: "positive regulation of adherens junction assembly and maintenance" EXACT [GOC:TermGenie]
synonym: "positive regulation of adherens junction organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of adherens junction assembly and maintenance" EXACT [GOC:TermGenie]
synonym: "up regulation of adherens junction organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of adherens junction organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of adherens junction assembly and maintenance" EXACT [GOC:TermGenie]
synonym: "up-regulation of adherens junction organisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of adherens junction organization" EXACT [GOC:TermGenie]
synonym: "upregulation of adherens junction assembly and maintenance" EXACT [GOC:TermGenie]
synonym: "upregulation of adherens junction organisation" EXACT [GOC:TermGenie]
synonym: "upregulation of adherens junction organization" EXACT [GOC:TermGenie]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1903391 ! regulation of adherens junction organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034332 ! adherens junction organization
relationship: positively_regulates GO:0034332 ! adherens junction organization
created_by: als
creation_date: 2014-08-27T10:08:55Z

[Term]
id: GO:1903394
name: protein localization to kinetochore involved in kinetochore assembly
namespace: biological_process
def: "Any protein localization to kinetochore that is involved in kinetochore assembly." [GO_REF:0000060, GOC:TermGenie, PMID:15369671]
synonym: "condensin localization to kinetochore involved in centromere and kinetochore complex maturation" NARROW [GOC:TermGenie]
synonym: "condensin localization to kinetochore involved in centromere/kinetochore complex maturation" NARROW [GOC:TermGenie]
synonym: "condensin localization to kinetochore involved in chromosome-kinetochore attachment" NARROW [GOC:TermGenie]
synonym: "condensin localization to kinetochore involved in kinetochore assembly" NARROW [GOC:TermGenie]
synonym: "condensin localization to kinetochore involved in kinetochore biogenesis" NARROW [GOC:TermGenie]
synonym: "condensin localization to kinetochore involved in kinetochore biosynthesis" NARROW [GOC:TermGenie]
synonym: "condensin localization to kinetochore involved in kinetochore formation" RELATED [GOC:TermGenie]
synonym: "protein localisation to kinetochore involved in centromere and kinetochore complex maturation" NARROW [GOC:TermGenie]
synonym: "protein localisation to kinetochore involved in centromere/kinetochore complex maturation" NARROW [GOC:TermGenie]
synonym: "protein localisation to kinetochore involved in chromosome-kinetochore attachment" NARROW [GOC:TermGenie]
synonym: "protein localisation to kinetochore involved in kinetochore assembly" EXACT [GOC:TermGenie]
synonym: "protein localisation to kinetochore involved in kinetochore biogenesis" EXACT [GOC:TermGenie]
synonym: "protein localisation to kinetochore involved in kinetochore biosynthesis" EXACT [GOC:TermGenie]
synonym: "protein localisation to kinetochore involved in kinetochore formation" RELATED [GOC:TermGenie]
synonym: "protein localization to kinetochore involved in centromere and kinetochore complex maturation" NARROW [GOC:TermGenie]
synonym: "protein localization to kinetochore involved in centromere/kinetochore complex maturation" NARROW [GOC:TermGenie]
synonym: "protein localization to kinetochore involved in chromosome-kinetochore attachment" NARROW [GOC:TermGenie]
synonym: "protein localization to kinetochore involved in kinetochore biogenesis" EXACT [GOC:TermGenie]
synonym: "protein localization to kinetochore involved in kinetochore biosynthesis" EXACT [GOC:TermGenie]
synonym: "protein localization to kinetochore involved in kinetochore formation" RELATED [GOC:TermGenie]
is_a: GO:0034501 ! protein localization to kinetochore
intersection_of: GO:0034501 ! protein localization to kinetochore
intersection_of: part_of GO:0051382 ! kinetochore assembly
relationship: part_of GO:0051382 ! kinetochore assembly
created_by: vw
creation_date: 2014-08-29T13:11:55Z

[Term]
id: GO:1903395
name: regulation of secondary cell septum biogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of secondary cell septum biogenesis." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:23878277]
is_a: GO:0032955 ! regulation of barrier septum assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990344 ! secondary cell septum biogenesis
relationship: regulates GO:1990344 ! secondary cell septum biogenesis
created_by: di
creation_date: 2014-08-29T21:42:17Z

[Term]
id: GO:1903396
name: negative regulation of secondary cell septum biogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of secondary cell septum biogenesis." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:23878277]
synonym: "down regulation of secondary cell septum biogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of secondary cell septum biogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of secondary cell septum biogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of secondary cell septum biogenesis" NARROW [GOC:TermGenie]
is_a: GO:0010974 ! negative regulation of barrier septum assembly
is_a: GO:1903395 ! regulation of secondary cell septum biogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990344 ! secondary cell septum biogenesis
relationship: negatively_regulates GO:1990344 ! secondary cell septum biogenesis
created_by: di
creation_date: 2014-08-29T21:42:26Z

[Term]
id: GO:1903397
name: positive regulation of secondary cell septum biogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of secondary cell septum biogenesis." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:23878277]
synonym: "activation of secondary cell septum biogenesis" NARROW [GOC:TermGenie]
synonym: "up regulation of secondary cell septum biogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of secondary cell septum biogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of secondary cell septum biogenesis" EXACT [GOC:TermGenie]
is_a: GO:0010973 ! positive regulation of barrier septum assembly
is_a: GO:1903395 ! regulation of secondary cell septum biogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990344 ! secondary cell septum biogenesis
relationship: positively_regulates GO:1990344 ! secondary cell septum biogenesis
created_by: di
creation_date: 2014-08-29T21:42:34Z

[Term]
id: GO:1903398
name: regulation of m7G(5')pppN diphosphatase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of m7G(5')pppN diphosphatase activity." [GO_REF:0000059, GOC:TermGenie, PMID:22323607]
synonym: "regulation of 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "regulation of decapase activity" RELATED [GOC:TermGenie]
synonym: "regulation of M(7)G(5')pppN pyrophosphatase activity" EXACT [GOC:TermGenie]
synonym: "regulation of m7G(5')pppN pyrophosphatase activity" EXACT [GOC:TermGenie]
is_a: GO:0051336 ! regulation of hydrolase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050072 ! m7G(5')pppN diphosphatase activity
relationship: regulates GO:0050072 ! m7G(5')pppN diphosphatase activity
created_by: mah
creation_date: 2014-09-01T10:16:40Z

[Term]
id: GO:1903399
name: positive regulation of m7G(5')pppN diphosphatase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of m7G(5')pppN diphosphatase activity." [GO_REF:0000059, GOC:TermGenie, PMID:22323607]
synonym: "activation of 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity" NARROW [GOC:TermGenie]
synonym: "activation of decapase activity" RELATED [GOC:TermGenie]
synonym: "activation of M(7)G(5')pppN pyrophosphatase activity" NARROW [GOC:TermGenie]
synonym: "activation of m7G(5')pppN diphosphatase activity" NARROW [GOC:TermGenie]
synonym: "activation of m7G(5')pppN pyrophosphatase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of decapase activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of M(7)G(5')pppN pyrophosphatase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of m7G(5')pppN pyrophosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of decapase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of M(7)G(5')pppN pyrophosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of m7G(5')pppN diphosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of m7G(5')pppN pyrophosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of decapase activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of M(7)G(5')pppN pyrophosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of m7G(5')pppN diphosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of m7G(5')pppN pyrophosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of decapase activity" RELATED [GOC:TermGenie]
synonym: "upregulation of M(7)G(5')pppN pyrophosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of m7G(5')pppN diphosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of m7G(5')pppN pyrophosphatase activity" EXACT [GOC:TermGenie]
is_a: GO:0051345 ! positive regulation of hydrolase activity
is_a: GO:1903398 ! regulation of m7G(5')pppN diphosphatase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0050072 ! m7G(5')pppN diphosphatase activity
relationship: positively_regulates GO:0050072 ! m7G(5')pppN diphosphatase activity
created_by: mah
creation_date: 2014-09-01T10:16:49Z

[Term]
id: GO:1903400
name: L-arginine transmembrane transport
namespace: biological_process
def: "The directed movement of L-arginine across a membrane." [GO_REF:0000069, GOC:krc, GOC:TermGenie, PMID:8195186]
is_a: GO:1902023 ! L-arginine transport
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport
is_a: GO:1903826 ! arginine transmembrane transport
created_by: pr
creation_date: 2014-09-01T13:45:48Z

[Term]
id: GO:1903401
name: L-lysine transmembrane transport
namespace: biological_process
def: "The directed movement of L-lysine across a membrane." [GO_REF:0000069, GOC:krc, GOC:TermGenie, PMID:8195186]
is_a: GO:0098655 ! cation transmembrane transport
is_a: GO:1902022 ! L-lysine transport
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport
created_by: pr
creation_date: 2014-09-01T13:45:56Z

[Term]
id: GO:1903402
name: regulation of renal phosphate excretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of renal phosphate excretion." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:8700837]
synonym: "regulation of renal phosphate ion excretion" EXACT [GOC:TermGenie]
is_a: GO:0044062 ! regulation of excretion
is_a: GO:0098801 ! regulation of renal system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044722 ! renal phosphate excretion
relationship: regulates GO:0044722 ! renal phosphate excretion
created_by: pm
creation_date: 2014-09-01T13:47:01Z

[Term]
id: GO:1903403
name: negative regulation of renal phosphate excretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of renal phosphate excretion." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:8700837]
synonym: "down regulation of renal phosphate excretion" EXACT [GOC:TermGenie]
synonym: "down regulation of renal phosphate ion excretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of renal phosphate excretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of renal phosphate ion excretion" EXACT [GOC:TermGenie]
synonym: "downregulation of renal phosphate excretion" EXACT [GOC:TermGenie]
synonym: "downregulation of renal phosphate ion excretion" EXACT [GOC:TermGenie]
synonym: "inhibition of renal phosphate excretion" NARROW [GOC:TermGenie]
synonym: "inhibition of renal phosphate ion excretion" NARROW [GOC:TermGenie]
synonym: "negative regulation of renal phosphate ion excretion" EXACT [GOC:TermGenie]
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1903402 ! regulation of renal phosphate excretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044722 ! renal phosphate excretion
relationship: negatively_regulates GO:0044722 ! renal phosphate excretion
created_by: pm
creation_date: 2014-09-01T13:47:10Z

[Term]
id: GO:1903404
name: positive regulation of renal phosphate excretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of renal phosphate excretion." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:8700837]
synonym: "activation of renal phosphate excretion" NARROW [GOC:TermGenie]
synonym: "activation of renal phosphate ion excretion" NARROW [GOC:TermGenie]
synonym: "positive regulation of renal phosphate ion excretion" EXACT [GOC:TermGenie]
synonym: "up regulation of renal phosphate excretion" EXACT [GOC:TermGenie]
synonym: "up regulation of renal phosphate ion excretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of renal phosphate excretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of renal phosphate ion excretion" EXACT [GOC:TermGenie]
synonym: "upregulation of renal phosphate excretion" EXACT [GOC:TermGenie]
synonym: "upregulation of renal phosphate ion excretion" EXACT [GOC:TermGenie]
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1903402 ! regulation of renal phosphate excretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044722 ! renal phosphate excretion
relationship: positively_regulates GO:0044722 ! renal phosphate excretion
created_by: pm
creation_date: 2014-09-01T13:47:18Z

[Term]
id: GO:1903405
name: protein localization to nuclear body
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a nuclear body." [GO_REF:0000087, GOC:TermGenie, PMID:24713849]
synonym: "protein localisation in nuclear body" EXACT [GOC:TermGenie]
synonym: "protein localisation to nuclear body" EXACT [GOC:TermGenie]
synonym: "protein localization in nuclear body" EXACT [GOC:TermGenie]
is_a: GO:1990173 ! protein localization to nucleoplasm
created_by: mah
creation_date: 2014-09-01T13:57:11Z

[Term]
id: GO:1903406
name: regulation of sodium:potassium-exchanging ATPase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sodium:potassium-exchanging ATPase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:8160880]
synonym: "regulation of (Na+ + K+)-activated ATPase activity" EXACT [GOC:TermGenie]
synonym: "regulation of (Na+ + K+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "regulation of ATP phosphohydrolase (Na+/K+-exchanging)" EXACT [GOC:TermGenie]
synonym: "regulation of Na(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "regulation of Na(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "regulation of Na+,K+ pump" RELATED [GOC:TermGenie]
synonym: "regulation of Na+,K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "regulation of Na+/K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "regulation of Na+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "regulation of Na,K-activated ATPase activity" EXACT [GOC:TermGenie]
synonym: "regulation of Na,K-pump" RELATED [GOC:TermGenie]
synonym: "regulation of sodium pump" BROAD [GOC:TermGenie]
synonym: "regulation of sodium/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "regulation of sodium/potassium-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "regulation of sodium:potassium exchanging ATPase activity" EXACT [GOC:TermGenie]
is_a: GO:0043462 ! regulation of ATPase activity
is_a: GO:1901016 ! regulation of potassium ion transmembrane transporter activity
is_a: GO:2000649 ! regulation of sodium ion transmembrane transporter activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0005391 ! sodium:potassium-exchanging ATPase activity
relationship: regulates GO:0005391 ! sodium:potassium-exchanging ATPase activity
created_by: mr
creation_date: 2014-09-02T19:45:08Z

[Term]
id: GO:1903407
name: negative regulation of sodium:potassium-exchanging ATPase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sodium:potassium-exchanging ATPase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:8160880]
synonym: "down regulation of (Na+ + K+)-activated ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of (Na+ + K+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of ATP phosphohydrolase (Na+/K+-exchanging)" EXACT [GOC:TermGenie]
synonym: "down regulation of Na(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of Na(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of Na+,K+ pump" RELATED [GOC:TermGenie]
synonym: "down regulation of Na+,K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of Na+/K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of Na+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of Na,K-activated ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of Na,K-pump" RELATED [GOC:TermGenie]
synonym: "down regulation of sodium/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of sodium/potassium-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of sodium:potassium exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of sodium:potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of (Na+ + K+)-activated ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of (Na+ + K+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of ATP phosphohydrolase (Na+/K+-exchanging)" EXACT [GOC:TermGenie]
synonym: "down-regulation of Na(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of Na(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of Na+,K+ pump" RELATED [GOC:TermGenie]
synonym: "down-regulation of Na+,K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of Na+/K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of Na+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of Na,K-activated ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of Na,K-pump" RELATED [GOC:TermGenie]
synonym: "down-regulation of sodium/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of sodium/potassium-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of sodium:potassium exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of sodium:potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of (Na+ + K+)-activated ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of (Na+ + K+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of ATP phosphohydrolase (Na+/K+-exchanging)" EXACT [GOC:TermGenie]
synonym: "downregulation of Na(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of Na(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of Na+,K+ pump" RELATED [GOC:TermGenie]
synonym: "downregulation of Na+,K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of Na+/K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of Na+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of Na,K-activated ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of Na,K-pump" RELATED [GOC:TermGenie]
synonym: "downregulation of sodium/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of sodium/potassium-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of sodium:potassium exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of sodium:potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of (Na+ + K+)-activated ATPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of (Na+ + K+)-ATPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of ATP phosphohydrolase (Na+/K+-exchanging)" NARROW [GOC:TermGenie]
synonym: "inhibition of Na(+)/K(+)-ATPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of Na(+)/K(+)-exchanging ATPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of Na+,K+ pump" RELATED [GOC:TermGenie]
synonym: "inhibition of Na+,K+-ATPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of Na+/K+-ATPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of Na+/K+-exchanging ATPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of Na,K-activated ATPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of Na,K-pump" RELATED [GOC:TermGenie]
synonym: "inhibition of sodium/potassium-exchanging ATPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of sodium/potassium-transporting ATPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of sodium:potassium exchanging ATPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of sodium:potassium-exchanging ATPase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of (Na+ + K+)-activated ATPase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of (Na+ + K+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of ATP phosphohydrolase (Na+/K+-exchanging)" EXACT [GOC:TermGenie]
synonym: "negative regulation of Na(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of Na(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of Na+,K+ pump" RELATED [GOC:TermGenie]
synonym: "negative regulation of Na+,K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of Na+/K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of Na+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of Na,K-activated ATPase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of Na,K-pump" RELATED [GOC:TermGenie]
synonym: "negative regulation of sodium/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of sodium/potassium-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of sodium:potassium exchanging ATPase activity" EXACT [GOC:TermGenie]
is_a: GO:0032780 ! negative regulation of ATPase activity
is_a: GO:1901017 ! negative regulation of potassium ion transmembrane transporter activity
is_a: GO:1903406 ! regulation of sodium:potassium-exchanging ATPase activity
is_a: GO:2000650 ! negative regulation of sodium ion transmembrane transporter activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0005391 ! sodium:potassium-exchanging ATPase activity
relationship: negatively_regulates GO:0005391 ! sodium:potassium-exchanging ATPase activity
created_by: mr
creation_date: 2014-09-02T19:45:16Z

[Term]
id: GO:1903408
name: positive regulation of sodium:potassium-exchanging ATPase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sodium:potassium-exchanging ATPase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:8160880]
synonym: "activation of (Na+ + K+)-activated ATPase activity" NARROW [GOC:TermGenie]
synonym: "activation of (Na+ + K+)-ATPase activity" NARROW [GOC:TermGenie]
synonym: "activation of ATP phosphohydrolase (Na+/K+-exchanging)" NARROW [GOC:TermGenie]
synonym: "activation of Na(+)/K(+)-ATPase activity" NARROW [GOC:TermGenie]
synonym: "activation of Na(+)/K(+)-exchanging ATPase activity" NARROW [GOC:TermGenie]
synonym: "activation of Na+,K+ pump" RELATED [GOC:TermGenie]
synonym: "activation of Na+,K+-ATPase activity" NARROW [GOC:TermGenie]
synonym: "activation of Na+/K+-ATPase activity" NARROW [GOC:TermGenie]
synonym: "activation of Na+/K+-exchanging ATPase activity" NARROW [GOC:TermGenie]
synonym: "activation of Na,K-activated ATPase activity" NARROW [GOC:TermGenie]
synonym: "activation of Na,K-pump" RELATED [GOC:TermGenie]
synonym: "activation of sodium/potassium-exchanging ATPase activity" NARROW [GOC:TermGenie]
synonym: "activation of sodium/potassium-transporting ATPase activity" NARROW [GOC:TermGenie]
synonym: "activation of sodium:potassium exchanging ATPase activity" NARROW [GOC:TermGenie]
synonym: "activation of sodium:potassium-exchanging ATPase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of (Na+ + K+)-activated ATPase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of (Na+ + K+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of ATP phosphohydrolase (Na+/K+-exchanging)" EXACT [GOC:TermGenie]
synonym: "positive regulation of Na(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of Na(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of Na+,K+ pump" RELATED [GOC:TermGenie]
synonym: "positive regulation of Na+,K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of Na+/K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of Na+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of Na,K-activated ATPase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of Na,K-pump" RELATED [GOC:TermGenie]
synonym: "positive regulation of sodium/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of sodium/potassium-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of sodium:potassium exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of (Na+ + K+)-activated ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of (Na+ + K+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of ATP phosphohydrolase (Na+/K+-exchanging)" EXACT [GOC:TermGenie]
synonym: "up regulation of Na(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of Na(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of Na+,K+ pump" RELATED [GOC:TermGenie]
synonym: "up regulation of Na+,K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of Na+/K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of Na+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of Na,K-activated ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of Na,K-pump" RELATED [GOC:TermGenie]
synonym: "up regulation of sodium/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of sodium/potassium-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of sodium:potassium exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of sodium:potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of (Na+ + K+)-activated ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of (Na+ + K+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of ATP phosphohydrolase (Na+/K+-exchanging)" EXACT [GOC:TermGenie]
synonym: "up-regulation of Na(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of Na(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of Na+,K+ pump" RELATED [GOC:TermGenie]
synonym: "up-regulation of Na+,K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of Na+/K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of Na+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of Na,K-activated ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of Na,K-pump" RELATED [GOC:TermGenie]
synonym: "up-regulation of sodium/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of sodium/potassium-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of sodium:potassium exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of sodium:potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of (Na+ + K+)-activated ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of (Na+ + K+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of ATP phosphohydrolase (Na+/K+-exchanging)" EXACT [GOC:TermGenie]
synonym: "upregulation of Na(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of Na(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of Na+,K+ pump" RELATED [GOC:TermGenie]
synonym: "upregulation of Na+,K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of Na+/K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of Na+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of Na,K-activated ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of Na,K-pump" RELATED [GOC:TermGenie]
synonym: "upregulation of sodium/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of sodium/potassium-transporting ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of sodium:potassium exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of sodium:potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
is_a: GO:0032781 ! positive regulation of ATPase activity
is_a: GO:1901018 ! positive regulation of potassium ion transmembrane transporter activity
is_a: GO:1903406 ! regulation of sodium:potassium-exchanging ATPase activity
is_a: GO:2000651 ! positive regulation of sodium ion transmembrane transporter activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0005391 ! sodium:potassium-exchanging ATPase activity
relationship: positively_regulates GO:0005391 ! sodium:potassium-exchanging ATPase activity
created_by: mr
creation_date: 2014-09-02T19:45:24Z

[Term]
id: GO:1903409
name: reactive oxygen species biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen." [GO_REF:0000068, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804]
synonym: "reactive oxygen species anabolism" EXACT [GOC:TermGenie]
synonym: "reactive oxygen species biosynthesis" EXACT [GOC:TermGenie]
synonym: "reactive oxygen species formation" EXACT [GOC:TermGenie]
synonym: "reactive oxygen species generation" RELATED [PMID:24252804]
synonym: "reactive oxygen species synthesis" EXACT [GOC:TermGenie]
synonym: "ROS formation" RELATED []
synonym: "ROS generation" RELATED [PMID:24252804]
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0072593 ! reactive oxygen species metabolic process
created_by: bf
creation_date: 2014-09-03T09:19:13Z

[Term]
id: GO:1903410
name: L-lysine import into cell
namespace: biological_process
def: "The directed movement of L-lysine into a cell." [GO_REF:0000075, GOC:krc, GOC:TermGenie, PMID:8195186]
is_a: GO:0061461 ! L-lysine import
created_by: pr
creation_date: 2014-09-03T09:32:57Z

[Term]
id: GO:1903411
name: L-ornithine import into cell
namespace: biological_process
def: "The directed movement of L-ornithine into a cell." [GO_REF:0000075, GOC:krc, GOC:TermGenie, PMID:8195186]
is_a: GO:0015822 ! ornithine transport
is_a: GO:0043092 ! L-amino acid import
created_by: pr
creation_date: 2014-09-03T09:48:14Z

[Term]
id: GO:1903412
name: response to bile acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bile acid stimulus." [GO_REF:0000071, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21757002]
is_a: GO:0001101 ! response to acid chemical
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033993 ! response to lipid
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: rl
creation_date: 2014-09-03T12:45:43Z

[Term]
id: GO:1903413
name: cellular response to bile acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bile acid stimulus." [GO_REF:0000071, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21757002]
is_a: GO:0071229 ! cellular response to acid chemical
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1903412 ! response to bile acid
created_by: rl
creation_date: 2014-09-03T12:45:51Z

[Term]
id: GO:1903414
name: iron cation export
namespace: biological_process
def: "The directed movement of iron cation out of a cell or organelle." [GO_REF:0000074, GOC:dph, GOC:TermGenie, PMID:15514116]
is_a: GO:0006826 ! iron ion transport
created_by: dph
creation_date: 2014-09-03T13:01:37Z

[Term]
id: GO:1903415
name: flavonoid transport from endoplasmic reticulum to plant-type vacuole
namespace: biological_process
def: "The directed movement of flavonoid from endoplasmic reticulum to plant-type vacuole." [GO_REF:0000078, GOC:tb, GOC:TermGenie, PMID:25116949]
synonym: "flavonoid accumulation in vacuole" RELATED []
is_a: GO:0007034 ! vacuolar transport
is_a: GO:0071702 ! organic substance transport
created_by: tb
creation_date: 2014-09-05T00:35:34Z

[Term]
id: GO:1903416
name: response to glycoside
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoside stimulus." [GO_REF:0000071, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:12027881, PMID:16243970]
synonym: "cellular response to ouabain" RELATED [CHEBI:472805]
is_a: GO:0010033 ! response to organic substance
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: rl
creation_date: 2014-09-05T12:41:01Z

[Term]
id: GO:1903418
name: protein localization to plasma membrane of cell tip
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a plasma membrane of cell tip." [GO_REF:0000087, GOC:TermGenie, PMID:25157670]
synonym: "protein localisation in plasma membrane of cell tip" EXACT [GOC:TermGenie]
synonym: "protein localisation to plasma membrane of cell tip" EXACT [GOC:TermGenie]
synonym: "protein localization in plasma membrane of cell tip" EXACT [GOC:TermGenie]
is_a: GO:0072659 ! protein localization to plasma membrane
is_a: GO:1990151 ! protein localization to cell tip
created_by: mah
creation_date: 2014-09-08T15:08:51Z

[Term]
id: GO:1903419
name: protein localization to cortical endoplasmic reticulum
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a cortical endoplasmic reticulum." [GO_REF:0000087, GOC:TermGenie, PMID:25103238]
synonym: "protein localisation in cortical endoplasmic reticulum" EXACT [GOC:TermGenie]
synonym: "protein localisation to cortical endoplasmic reticulum" EXACT [GOC:TermGenie]
synonym: "protein localization in cortical endoplasmic reticulum" EXACT [GOC:TermGenie]
synonym: "protein localization to cortical ER" EXACT []
is_a: GO:0072697 ! protein localization to cell cortex
is_a: GO:1903420 ! protein localization to endoplasmic reticulum tubular network
created_by: mah
creation_date: 2014-09-08T16:03:28Z

[Term]
id: GO:1903420
name: protein localization to endoplasmic reticulum tubular network
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within an endoplasmic reticulum tubular network." [GO_REF:0000087, GOC:TermGenie, PMID:25103238]
synonym: "protein localisation in endoplasmic reticulum tubular network" EXACT [GOC:TermGenie]
synonym: "protein localisation to endoplasmic reticulum tubular network" EXACT [GOC:TermGenie]
synonym: "protein localization in endoplasmic reticulum tubular network" EXACT [GOC:TermGenie]
synonym: "protein localization to tubular ER" RELATED [PMID:25103238]
is_a: GO:0070972 ! protein localization to endoplasmic reticulum
created_by: mah
creation_date: 2014-09-08T16:03:37Z

[Term]
id: GO:1903421
name: regulation of synaptic vesicle recycling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synaptic vesicle recycling." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22745285]
comment: An example of this is mouse LRRK2 (Q5S006) in PMID:21307259 inferred from mutant phenotype
synonym: "regulation of kiss-and-run synaptic vesicle recycling" NARROW [GOC:TermGenie]
synonym: "regulation of kiss-and-stay synaptic vesicle recycling" NARROW [GOC:TermGenie]
is_a: GO:1902803 ! regulation of synaptic vesicle transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0036465 ! synaptic vesicle recycling
relationship: regulates GO:0036465 ! synaptic vesicle recycling
created_by: pad
creation_date: 2014-09-09T15:27:50Z

[Term]
id: GO:1903422
name: negative regulation of synaptic vesicle recycling
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle recycling." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22745285]
comment: An example of this is mouse LRRK2 (Q5S006) in PMID:21307259 inferred from mutant phenotype
synonym: "down regulation of kiss-and-run synaptic vesicle recycling" NARROW [GOC:TermGenie]
synonym: "down regulation of kiss-and-stay synaptic vesicle recycling" NARROW [GOC:TermGenie]
synonym: "down regulation of synaptic vesicle recycling" EXACT [GOC:TermGenie]
synonym: "down-regulation of kiss-and-run synaptic vesicle recycling" NARROW [GOC:TermGenie]
synonym: "down-regulation of kiss-and-stay synaptic vesicle recycling" NARROW [GOC:TermGenie]
synonym: "down-regulation of synaptic vesicle recycling" EXACT [GOC:TermGenie]
synonym: "downregulation of kiss-and-run synaptic vesicle recycling" NARROW [GOC:TermGenie]
synonym: "downregulation of kiss-and-stay synaptic vesicle recycling" NARROW [GOC:TermGenie]
synonym: "downregulation of synaptic vesicle recycling" EXACT [GOC:TermGenie]
synonym: "inhibition of kiss-and-run synaptic vesicle recycling" NARROW [GOC:TermGenie]
synonym: "inhibition of kiss-and-stay synaptic vesicle recycling" NARROW [GOC:TermGenie]
synonym: "inhibition of synaptic vesicle recycling" NARROW [GOC:TermGenie]
synonym: "negative regulation of kiss-and-run synaptic vesicle recycling" NARROW [GOC:TermGenie]
synonym: "negative regulation of kiss-and-stay synaptic vesicle recycling" NARROW [GOC:TermGenie]
is_a: GO:1902804 ! negative regulation of synaptic vesicle transport
is_a: GO:1903421 ! regulation of synaptic vesicle recycling
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0036465 ! synaptic vesicle recycling
relationship: negatively_regulates GO:0036465 ! synaptic vesicle recycling
created_by: pad
creation_date: 2014-09-09T15:27:59Z

[Term]
id: GO:1903423
name: positive regulation of synaptic vesicle recycling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of synaptic vesicle recycling." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22745285]
comment: An example of this is mouse LRRK2 (Q5S006) in PMID:21307259 inferred from mutant phenotype
synonym: "activation of kiss-and-run synaptic vesicle recycling" NARROW [GOC:TermGenie]
synonym: "activation of kiss-and-stay synaptic vesicle recycling" NARROW [GOC:TermGenie]
synonym: "activation of synaptic vesicle recycling" NARROW [GOC:TermGenie]
synonym: "positive regulation of kiss-and-run synaptic vesicle recycling" NARROW [GOC:TermGenie]
synonym: "positive regulation of kiss-and-stay synaptic vesicle recycling" NARROW [GOC:TermGenie]
synonym: "up regulation of kiss-and-run synaptic vesicle recycling" NARROW [GOC:TermGenie]
synonym: "up regulation of kiss-and-stay synaptic vesicle recycling" NARROW [GOC:TermGenie]
synonym: "up regulation of synaptic vesicle recycling" EXACT [GOC:TermGenie]
synonym: "up-regulation of kiss-and-run synaptic vesicle recycling" NARROW [GOC:TermGenie]
synonym: "up-regulation of kiss-and-stay synaptic vesicle recycling" NARROW [GOC:TermGenie]
synonym: "up-regulation of synaptic vesicle recycling" EXACT [GOC:TermGenie]
synonym: "upregulation of kiss-and-run synaptic vesicle recycling" NARROW [GOC:TermGenie]
synonym: "upregulation of kiss-and-stay synaptic vesicle recycling" NARROW [GOC:TermGenie]
synonym: "upregulation of synaptic vesicle recycling" EXACT [GOC:TermGenie]
is_a: GO:1902805 ! positive regulation of synaptic vesicle transport
is_a: GO:1903421 ! regulation of synaptic vesicle recycling
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0036465 ! synaptic vesicle recycling
relationship: positively_regulates GO:0036465 ! synaptic vesicle recycling
created_by: pad
creation_date: 2014-09-09T15:28:07Z

[Term]
id: GO:1903424
name: fluoride transmembrane transport
namespace: biological_process
def: "The directed movement of fluoride across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:24173035]
synonym: "fluoride membrane transport" EXACT []
synonym: "transmembrane fluoride transport" EXACT []
is_a: GO:0098661 ! inorganic anion transmembrane transport
created_by: mcc
creation_date: 2014-09-09T21:21:01Z

[Term]
id: GO:1903425
name: fluoride transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of fluoride from one side of the membrane to the other." [GO_REF:0000070, GOC:TermGenie, PMID:24173035]
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity
relationship: part_of GO:1903424 ! fluoride transmembrane transport
created_by: mcc
creation_date: 2014-09-09T21:27:55Z

[Term]
id: GO:1903426
name: regulation of reactive oxygen species biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of reactive oxygen species biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804]
synonym: "regulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species formation" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species generation" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie]
synonym: "regulation of ROS formation" RELATED [GOC:TermGenie]
synonym: "regulation of ROS generation" RELATED [GOC:TermGenie]
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:2000377 ! regulation of reactive oxygen species metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1903409 ! reactive oxygen species biosynthetic process
relationship: regulates GO:1903409 ! reactive oxygen species biosynthetic process
created_by: bf
creation_date: 2014-09-11T10:01:47Z

[Term]
id: GO:1903427
name: negative regulation of reactive oxygen species biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804]
synonym: "down regulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of reactive oxygen species biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of reactive oxygen species formation" EXACT [GOC:TermGenie]
synonym: "down regulation of reactive oxygen species generation" RELATED [GOC:TermGenie]
synonym: "down regulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of ROS formation" RELATED [GOC:TermGenie]
synonym: "down regulation of ROS generation" RELATED [GOC:TermGenie]
synonym: "down-regulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of reactive oxygen species biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of reactive oxygen species formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of reactive oxygen species generation" RELATED [GOC:TermGenie]
synonym: "down-regulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of ROS formation" RELATED [GOC:TermGenie]
synonym: "down-regulation of ROS generation" RELATED [GOC:TermGenie]
synonym: "downregulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of reactive oxygen species biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of reactive oxygen species formation" EXACT [GOC:TermGenie]
synonym: "downregulation of reactive oxygen species generation" RELATED [GOC:TermGenie]
synonym: "downregulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of ROS formation" RELATED [GOC:TermGenie]
synonym: "downregulation of ROS generation" RELATED [GOC:TermGenie]
synonym: "inhibition of reactive oxygen species anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of reactive oxygen species biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of reactive oxygen species biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of reactive oxygen species formation" NARROW [GOC:TermGenie]
synonym: "inhibition of reactive oxygen species generation" RELATED [GOC:TermGenie]
synonym: "inhibition of reactive oxygen species synthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of ROS formation" RELATED [GOC:TermGenie]
synonym: "inhibition of ROS generation" RELATED [GOC:TermGenie]
synonym: "negative regulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of reactive oxygen species formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of reactive oxygen species generation" RELATED [GOC:TermGenie]
synonym: "negative regulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of ROS formation" RELATED [GOC:TermGenie]
synonym: "negative regulation of ROS generation" RELATED [GOC:TermGenie]
synonym: "prevention of ROS generation" EXACT [PMID:24252804]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:1903426 ! regulation of reactive oxygen species biosynthetic process
is_a: GO:2000378 ! negative regulation of reactive oxygen species metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1903409 ! reactive oxygen species biosynthetic process
relationship: negatively_regulates GO:1903409 ! reactive oxygen species biosynthetic process
created_by: bf
creation_date: 2014-09-11T10:01:56Z

[Term]
id: GO:1903428
name: positive regulation of reactive oxygen species biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of reactive oxygen species biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804]
synonym: "activation of reactive oxygen species anabolism" NARROW [GOC:TermGenie]
synonym: "activation of reactive oxygen species biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of reactive oxygen species biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of reactive oxygen species formation" NARROW [GOC:TermGenie]
synonym: "activation of reactive oxygen species generation" RELATED [GOC:TermGenie]
synonym: "activation of reactive oxygen species synthesis" NARROW [GOC:TermGenie]
synonym: "activation of ROS formation" RELATED [GOC:TermGenie]
synonym: "activation of ROS generation" RELATED [GOC:TermGenie]
synonym: "positive regulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of reactive oxygen species formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of reactive oxygen species generation" RELATED [GOC:TermGenie]
synonym: "positive regulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of ROS formation" RELATED [GOC:TermGenie]
synonym: "positive regulation of ROS generation" RELATED [GOC:TermGenie]
synonym: "up regulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of reactive oxygen species biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of reactive oxygen species formation" EXACT [GOC:TermGenie]
synonym: "up regulation of reactive oxygen species generation" RELATED [GOC:TermGenie]
synonym: "up regulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of ROS formation" RELATED [GOC:TermGenie]
synonym: "up regulation of ROS generation" RELATED [GOC:TermGenie]
synonym: "up-regulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of reactive oxygen species biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of reactive oxygen species formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of reactive oxygen species generation" RELATED [GOC:TermGenie]
synonym: "up-regulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of ROS formation" RELATED [GOC:TermGenie]
synonym: "up-regulation of ROS generation" RELATED [GOC:TermGenie]
synonym: "upregulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of reactive oxygen species biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of reactive oxygen species formation" EXACT [GOC:TermGenie]
synonym: "upregulation of reactive oxygen species generation" RELATED [GOC:TermGenie]
synonym: "upregulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of ROS formation" RELATED [GOC:TermGenie]
synonym: "upregulation of ROS generation" RELATED [GOC:TermGenie]
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:1903426 ! regulation of reactive oxygen species biosynthetic process
is_a: GO:2000379 ! positive regulation of reactive oxygen species metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1903409 ! reactive oxygen species biosynthetic process
relationship: positively_regulates GO:1903409 ! reactive oxygen species biosynthetic process
created_by: bf
creation_date: 2014-09-11T10:02:05Z

[Term]
id: GO:1903429
name: regulation of cell maturation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell maturation." [GO_REF:0000058, GOC:TermGenie, PMID:17459944]
synonym: "regulation of functional differentiation" RELATED [GOC:TermGenie]
is_a: GO:0060284 ! regulation of cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048469 ! cell maturation
relationship: regulates GO:0048469 ! cell maturation
created_by: jl
creation_date: 2014-09-15T13:31:23Z

[Term]
id: GO:1903430
name: negative regulation of cell maturation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell maturation." [GO_REF:0000058, GOC:TermGenie, PMID:17459944]
synonym: "down regulation of cell maturation" EXACT [GOC:TermGenie]
synonym: "down regulation of functional differentiation" RELATED [GOC:TermGenie]
synonym: "down-regulation of cell maturation" EXACT [GOC:TermGenie]
synonym: "down-regulation of functional differentiation" RELATED [GOC:TermGenie]
synonym: "downregulation of cell maturation" EXACT [GOC:TermGenie]
synonym: "downregulation of functional differentiation" RELATED [GOC:TermGenie]
synonym: "inhibition of cell maturation" NARROW [GOC:TermGenie]
synonym: "inhibition of functional differentiation" RELATED [GOC:TermGenie]
synonym: "negative regulation of functional differentiation" RELATED [GOC:TermGenie]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:1903429 ! regulation of cell maturation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048469 ! cell maturation
relationship: negatively_regulates GO:0048469 ! cell maturation
created_by: jl
creation_date: 2014-09-15T13:31:32Z

[Term]
id: GO:1903431
name: positive regulation of cell maturation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell maturation." [GO_REF:0000058, GOC:TermGenie, PMID:17459944]
synonym: "activation of cell maturation" NARROW [GOC:TermGenie]
synonym: "activation of functional differentiation" RELATED [GOC:TermGenie]
synonym: "positive regulation of functional differentiation" RELATED [GOC:TermGenie]
synonym: "up regulation of cell maturation" EXACT [GOC:TermGenie]
synonym: "up regulation of functional differentiation" RELATED [GOC:TermGenie]
synonym: "up-regulation of cell maturation" EXACT [GOC:TermGenie]
synonym: "up-regulation of functional differentiation" RELATED [GOC:TermGenie]
synonym: "upregulation of cell maturation" EXACT [GOC:TermGenie]
synonym: "upregulation of functional differentiation" RELATED [GOC:TermGenie]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:1903429 ! regulation of cell maturation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048469 ! cell maturation
relationship: positively_regulates GO:0048469 ! cell maturation
created_by: jl
creation_date: 2014-09-15T13:31:41Z

[Term]
id: GO:1903432
name: regulation of TORC1 signaling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of TORC1 signaling." [GO_REF:0000058, GOC:TermGenie]
synonym: "regulation of TORC1 signal transduction" EXACT [GOC:TermGenie]
is_a: GO:0032006 ! regulation of TOR signaling
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0038202 ! TORC1 signaling
relationship: regulates GO:0038202 ! TORC1 signaling
created_by: jl
creation_date: 2014-09-15T13:35:39Z

[Term]
id: GO:1903433
name: regulation of constitutive secretory pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of constitutive secretory pathway." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22899725]
is_a: GO:0017157 ! regulation of exocytosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045054 ! constitutive secretory pathway
relationship: regulates GO:0045054 ! constitutive secretory pathway
created_by: als
creation_date: 2014-09-15T15:07:31Z

[Term]
id: GO:1903434
name: negative regulation of constitutive secretory pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of constitutive secretory pathway." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22899725]
synonym: "down regulation of constitutive secretory pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of constitutive secretory pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of constitutive secretory pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of constitutive secretory pathway" NARROW [GOC:TermGenie]
is_a: GO:0045920 ! negative regulation of exocytosis
is_a: GO:1903433 ! regulation of constitutive secretory pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045054 ! constitutive secretory pathway
relationship: negatively_regulates GO:0045054 ! constitutive secretory pathway
created_by: als
creation_date: 2014-09-15T15:07:40Z

[Term]
id: GO:1903435
name: positive regulation of constitutive secretory pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of constitutive secretory pathway." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22899725]
synonym: "activation of constitutive secretory pathway" NARROW [GOC:TermGenie]
synonym: "up regulation of constitutive secretory pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of constitutive secretory pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of constitutive secretory pathway" EXACT [GOC:TermGenie]
is_a: GO:0045921 ! positive regulation of exocytosis
is_a: GO:1903433 ! regulation of constitutive secretory pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045054 ! constitutive secretory pathway
relationship: positively_regulates GO:0045054 ! constitutive secretory pathway
created_by: als
creation_date: 2014-09-15T15:07:48Z

[Term]
id: GO:1903436
name: regulation of mitotic cytokinetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitotic cytokinetic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
is_a: GO:0032954 ! regulation of cytokinetic process
is_a: GO:1902412 ! regulation of mitotic cytokinesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1902410 ! mitotic cytokinetic process
relationship: regulates GO:1902410 ! mitotic cytokinetic process
created_by: tb
creation_date: 2014-09-15T23:11:38Z

[Term]
id: GO:1903437
name: negative regulation of mitotic cytokinetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cytokinetic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "down regulation of mitotic cytokinetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitotic cytokinetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of mitotic cytokinetic process" EXACT [GOC:TermGenie]
synonym: "inhibition of mitotic cytokinetic process" NARROW [GOC:TermGenie]
is_a: GO:1902413 ! negative regulation of mitotic cytokinesis
is_a: GO:1903436 ! regulation of mitotic cytokinetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1902410 ! mitotic cytokinetic process
relationship: negatively_regulates GO:1902410 ! mitotic cytokinetic process
created_by: tb
creation_date: 2014-09-15T23:11:47Z

[Term]
id: GO:1903438
name: positive regulation of mitotic cytokinetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitotic cytokinetic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "activation of mitotic cytokinetic process" NARROW [GOC:TermGenie]
synonym: "up regulation of mitotic cytokinetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitotic cytokinetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of mitotic cytokinetic process" EXACT [GOC:TermGenie]
is_a: GO:1903436 ! regulation of mitotic cytokinetic process
is_a: GO:1903490 ! positive regulation of mitotic cytokinesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1902410 ! mitotic cytokinetic process
relationship: positively_regulates GO:1902410 ! mitotic cytokinetic process
created_by: tb
creation_date: 2014-09-15T23:11:55Z

[Term]
id: GO:1903439
name: calcitonin family receptor complex
namespace: cellular_component
def: "A protein complex which is capable of calcitonin family receptor activity. Calcitonin family receptors may form dimers, trimers or tetramers; adrenomedullin and amylin receptors have only been observed as dimers so far." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:10871296, PMID:12037140, PMID:18687416]
is_a: GO:0097648 ! G-protein coupled receptor complex
relationship: part_of GO:0005887 ! integral component of plasma membrane
created_by: pr
creation_date: 2014-09-16T13:25:11Z

[Term]
id: GO:1903440
name: amylin receptor complex
namespace: cellular_component
def: "A protein complex which is capable of amylin receptor activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:10871296, PMID:12037140, PMID:18687416]
is_a: GO:0038037 ! G-protein coupled receptor dimeric complex
is_a: GO:1903439 ! calcitonin family receptor complex
created_by: pr
creation_date: 2014-09-16T13:25:20Z

[Term]
id: GO:1903441
name: protein localization to ciliary membrane
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a ciliary membrane." [GO_REF:0000087, GOC:krc, GOC:TermGenie, PMID:22139371]
synonym: "protein localisation in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "protein localisation to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "protein localization in ciliary membrane" EXACT [GOC:TermGenie]
is_a: GO:0061512 ! protein localization to cilium
is_a: GO:0072659 ! protein localization to plasma membrane
created_by: pr
creation_date: 2014-09-16T15:15:39Z

[Term]
id: GO:1903442
name: response to lipoic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoic acid stimulus." [GO_REF:0000071, GOC:sl, GOC:TermGenie, PMID:23232760]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0070542 ! response to fatty acid
created_by: jl
creation_date: 2014-09-17T13:52:03Z

[Term]
id: GO:1903443
name: cellular response to lipoic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoic acid stimulus." [GO_REF:0000071, GOC:sl, GOC:TermGenie, PMID:23232760]
is_a: GO:0071398 ! cellular response to fatty acid
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1903442 ! response to lipoic acid
created_by: jl
creation_date: 2014-09-17T13:52:12Z

[Term]
id: GO:1903444
name: negative regulation of brown fat cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of brown fat cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:23977283]
synonym: "down regulation of brown adipocyte cell differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of brown adipocyte differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of brown fat cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of brown adipocyte cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of brown adipocyte differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of brown fat cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of brown adipocyte cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of brown adipocyte differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of brown fat cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of brown adipocyte cell differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of brown adipocyte differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of brown fat cell differentiation" NARROW [GOC:TermGenie]
synonym: "negative regulation of brown adipocyte cell differentiation" EXACT [GOC:TermGenie]
synonym: "negative regulation of brown adipocyte differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045599 ! negative regulation of fat cell differentiation
is_a: GO:0090335 ! regulation of brown fat cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0050873 ! brown fat cell differentiation
relationship: negatively_regulates GO:0050873 ! brown fat cell differentiation
created_by: hjd
creation_date: 2014-09-17T19:15:00Z

[Term]
id: GO:1903445
name: protein transport from ciliary membrane to plasma membrane
namespace: biological_process
def: "The directed movement of protein from ciliary membrane to plasma membrane." [GO_REF:0000078, GOC:krc, GOC:TermGenie, PMID:22139371]
is_a: GO:0032594 ! protein transport within lipid bilayer
is_a: GO:0046909 ! intermembrane transport
is_a: GO:0072659 ! protein localization to plasma membrane
is_a: GO:0090002 ! establishment of protein localization to plasma membrane
created_by: pr
creation_date: 2014-09-18T07:46:10Z

[Term]
id: GO:1903446
name: geraniol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving geraniol." [GO_REF:0000068, GOC:di, GOC:TermGenie, PMID:23200656]
synonym: "geraniol metabolism" EXACT [GOC:TermGenie]
is_a: GO:0016093 ! polyprenol metabolic process
is_a: GO:0016098 ! monoterpenoid metabolic process
is_a: GO:0034308 ! primary alcohol metabolic process
created_by: di
creation_date: 2014-09-19T08:18:34Z

[Term]
id: GO:1903447
name: geraniol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of geraniol." [GO_REF:0000068, GOC:di, GOC:TermGenie, PMID:23200656]
synonym: "geraniol breakdown" EXACT [GOC:TermGenie]
synonym: "geraniol catabolism" EXACT [GOC:TermGenie]
synonym: "geraniol degradation" EXACT [GOC:TermGenie]
is_a: GO:0016095 ! polyprenol catabolic process
is_a: GO:0016100 ! monoterpenoid catabolic process
is_a: GO:0034310 ! primary alcohol catabolic process
is_a: GO:1903446 ! geraniol metabolic process
created_by: di
creation_date: 2014-09-19T08:18:44Z

[Term]
id: GO:1903448
name: geraniol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of geraniol." [GO_REF:0000068, GOC:di, GOC:TermGenie, PMID:23200656]
synonym: "geraniol anabolism" EXACT [GOC:TermGenie]
synonym: "geraniol biosynthesis" EXACT [GOC:TermGenie]
synonym: "geraniol formation" EXACT [GOC:TermGenie]
synonym: "geraniol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0016094 ! polyprenol biosynthetic process
is_a: GO:0016099 ! monoterpenoid biosynthetic process
is_a: GO:0034309 ! primary alcohol biosynthetic process
is_a: GO:1903446 ! geraniol metabolic process
created_by: di
creation_date: 2014-09-19T08:18:52Z

[Term]
id: GO:1903449
name: androst-4-ene-3,17-dione biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of androst-4-ene-3,17-dione." [GO_REF:0000068, GOC:mr, GOC:TermGenie, PMID:2028480, PMID:4149619]
synonym: "androst-4-ene-3,17-dione anabolism" EXACT [GOC:TermGenie]
synonym: "androst-4-ene-3,17-dione biosynthesis" EXACT [GOC:TermGenie]
synonym: "androst-4-ene-3,17-dione formation" EXACT [GOC:TermGenie]
synonym: "androst-4-ene-3,17-dione synthesis" EXACT [GOC:TermGenie]
synonym: "androstenedione" EXACT []
is_a: GO:0006694 ! steroid biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process
created_by: mr
creation_date: 2014-09-19T20:18:19Z

[Term]
id: GO:1903450
name: regulation of G1 to G0 transition
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of G1 to G0 transition." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:24088570]
synonym: "regulation of cell cycle quiescence" RELATED [GOC:TermGenie]
synonym: "regulation of establishment of cell quiescence" EXACT [GOC:TermGenie]
synonym: "regulation of G1/G0 transition" EXACT [GOC:TermGenie]
synonym: "regulation of stationary phase" RELATED [GOC:TermGenie]
is_a: GO:0010564 ! regulation of cell cycle process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070314 ! G1 to G0 transition
relationship: regulates GO:0070314 ! G1 to G0 transition
created_by: di
creation_date: 2014-09-19T22:23:13Z

[Term]
id: GO:1903451
name: negative regulation of G1 to G0 transition
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of G1 to G0 transition." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:24088570]
synonym: "down regulation of cell cycle quiescence" RELATED [GOC:TermGenie]
synonym: "down regulation of establishment of cell quiescence" EXACT [GOC:TermGenie]
synonym: "down regulation of G1 to G0 transition" EXACT [GOC:TermGenie]
synonym: "down regulation of G1/G0 transition" EXACT [GOC:TermGenie]
synonym: "down regulation of stationary phase" RELATED [GOC:TermGenie]
synonym: "down-regulation of cell cycle quiescence" RELATED [GOC:TermGenie]
synonym: "down-regulation of establishment of cell quiescence" EXACT [GOC:TermGenie]
synonym: "down-regulation of G1 to G0 transition" EXACT [GOC:TermGenie]
synonym: "down-regulation of G1/G0 transition" EXACT [GOC:TermGenie]
synonym: "down-regulation of stationary phase" RELATED [GOC:TermGenie]
synonym: "downregulation of cell cycle quiescence" RELATED [GOC:TermGenie]
synonym: "downregulation of establishment of cell quiescence" EXACT [GOC:TermGenie]
synonym: "downregulation of G1 to G0 transition" EXACT [GOC:TermGenie]
synonym: "downregulation of G1/G0 transition" EXACT [GOC:TermGenie]
synonym: "downregulation of stationary phase" RELATED [GOC:TermGenie]
synonym: "inhibition of cell cycle quiescence" RELATED [GOC:TermGenie]
synonym: "inhibition of establishment of cell quiescence" NARROW [GOC:TermGenie]
synonym: "inhibition of G1 to G0 transition" NARROW [GOC:TermGenie]
synonym: "inhibition of G1/G0 transition" NARROW [GOC:TermGenie]
synonym: "inhibition of stationary phase" RELATED [GOC:TermGenie]
synonym: "negative regulation of cell cycle quiescence" RELATED [GOC:TermGenie]
synonym: "negative regulation of establishment of cell quiescence" EXACT [GOC:TermGenie]
synonym: "negative regulation of G1/G0 transition" EXACT [GOC:TermGenie]
synonym: "negative regulation of stationary phase" RELATED [GOC:TermGenie]
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:1903450 ! regulation of G1 to G0 transition
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070314 ! G1 to G0 transition
relationship: negatively_regulates GO:0070314 ! G1 to G0 transition
created_by: di
creation_date: 2014-09-19T22:23:22Z

[Term]
id: GO:1903452
name: positive regulation of G1 to G0 transition
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of G1 to G0 transition." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:24088570]
synonym: "activation of cell cycle quiescence" RELATED [GOC:TermGenie]
synonym: "activation of establishment of cell quiescence" NARROW [GOC:TermGenie]
synonym: "activation of G1 to G0 transition" NARROW [GOC:TermGenie]
synonym: "activation of G1/G0 transition" NARROW [GOC:TermGenie]
synonym: "activation of stationary phase" RELATED [GOC:TermGenie]
synonym: "positive regulation of cell cycle quiescence" RELATED [GOC:TermGenie]
synonym: "positive regulation of establishment of cell quiescence" EXACT [GOC:TermGenie]
synonym: "positive regulation of G1/G0 transition" EXACT [GOC:TermGenie]
synonym: "positive regulation of stationary phase" RELATED [GOC:TermGenie]
synonym: "up regulation of cell cycle quiescence" RELATED [GOC:TermGenie]
synonym: "up regulation of establishment of cell quiescence" EXACT [GOC:TermGenie]
synonym: "up regulation of G1 to G0 transition" EXACT [GOC:TermGenie]
synonym: "up regulation of G1/G0 transition" EXACT [GOC:TermGenie]
synonym: "up regulation of stationary phase" RELATED [GOC:TermGenie]
synonym: "up-regulation of cell cycle quiescence" RELATED [GOC:TermGenie]
synonym: "up-regulation of establishment of cell quiescence" EXACT [GOC:TermGenie]
synonym: "up-regulation of G1 to G0 transition" EXACT [GOC:TermGenie]
synonym: "up-regulation of G1/G0 transition" EXACT [GOC:TermGenie]
synonym: "up-regulation of stationary phase" RELATED [GOC:TermGenie]
synonym: "upregulation of cell cycle quiescence" RELATED [GOC:TermGenie]
synonym: "upregulation of establishment of cell quiescence" EXACT [GOC:TermGenie]
synonym: "upregulation of G1 to G0 transition" EXACT [GOC:TermGenie]
synonym: "upregulation of G1/G0 transition" EXACT [GOC:TermGenie]
synonym: "upregulation of stationary phase" RELATED [GOC:TermGenie]
is_a: GO:0090068 ! positive regulation of cell cycle process
is_a: GO:1903450 ! regulation of G1 to G0 transition
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070314 ! G1 to G0 transition
relationship: positively_regulates GO:0070314 ! G1 to G0 transition
created_by: di
creation_date: 2014-09-19T22:23:30Z

[Term]
id: GO:1903453
name: RNA interference involved in olfactory learning
namespace: biological_process
def: "Any RNA interference that is involved in olfactory learning." [GO_REF:0000060, GOC:kmv, GOC:TermGenie, PMID:23993094]
synonym: "posttranscriptional gene silencing by siRNA involved in olfactory learning" EXACT [GOC:TermGenie]
synonym: "RNAi involved in olfactory learning" EXACT [GOC:TermGenie]
is_a: GO:0016246 ! RNA interference
intersection_of: GO:0016246 ! RNA interference
intersection_of: part_of GO:0008355 ! olfactory learning
relationship: part_of GO:0008355 ! olfactory learning
created_by: kmv
creation_date: 2014-09-22T13:50:09Z

[Term]
id: GO:1903454
name: regulation of androst-4-ene-3,17-dione biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of androst-4-ene-3,17-dione biosynthetic process." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:24399684]
synonym: "regulation of androst-4-ene-3,17-dione anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of androst-4-ene-3,17-dione biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of androst-4-ene-3,17-dione formation" EXACT [GOC:TermGenie]
synonym: "regulation of androst-4-ene-3,17-dione synthesis" EXACT [GOC:TermGenie]
synonym: "regulation of androstenedione" EXACT [GOC:TermGenie]
is_a: GO:0010566 ! regulation of ketone biosynthetic process
is_a: GO:0050810 ! regulation of steroid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1903449 ! androst-4-ene-3,17-dione biosynthetic process
relationship: regulates GO:1903449 ! androst-4-ene-3,17-dione biosynthetic process
created_by: mr
creation_date: 2014-09-22T14:36:50Z

[Term]
id: GO:1903455
name: negative regulation of androst-4-ene-3,17-dione biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of androst-4-ene-3,17-dione biosynthetic process." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:24399684]
synonym: "down regulation of androst-4-ene-3,17-dione anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of androst-4-ene-3,17-dione biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of androst-4-ene-3,17-dione biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of androst-4-ene-3,17-dione formation" EXACT [GOC:TermGenie]
synonym: "down regulation of androst-4-ene-3,17-dione synthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of androstenedione" EXACT [GOC:TermGenie]
synonym: "down-regulation of androst-4-ene-3,17-dione anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of androst-4-ene-3,17-dione biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of androst-4-ene-3,17-dione biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of androst-4-ene-3,17-dione formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of androst-4-ene-3,17-dione synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of androstenedione" EXACT [GOC:TermGenie]
synonym: "downregulation of androst-4-ene-3,17-dione anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of androst-4-ene-3,17-dione biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of androst-4-ene-3,17-dione biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of androst-4-ene-3,17-dione formation" EXACT [GOC:TermGenie]
synonym: "downregulation of androst-4-ene-3,17-dione synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of androstenedione" EXACT [GOC:TermGenie]
synonym: "inhibition of androst-4-ene-3,17-dione anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of androst-4-ene-3,17-dione biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of androst-4-ene-3,17-dione biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of androst-4-ene-3,17-dione formation" NARROW [GOC:TermGenie]
synonym: "inhibition of androst-4-ene-3,17-dione synthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of androstenedione" NARROW [GOC:TermGenie]
synonym: "negative regulation of androst-4-ene-3,17-dione anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of androst-4-ene-3,17-dione biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of androst-4-ene-3,17-dione formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of androst-4-ene-3,17-dione synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of androstenedione" EXACT [GOC:TermGenie]
is_a: GO:0010894 ! negative regulation of steroid biosynthetic process
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:1903454 ! regulation of androst-4-ene-3,17-dione biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1903449 ! androst-4-ene-3,17-dione biosynthetic process
relationship: negatively_regulates GO:1903449 ! androst-4-ene-3,17-dione biosynthetic process
created_by: mr
creation_date: 2014-09-22T14:36:59Z

[Term]
id: GO:1903456
name: positive regulation of androst-4-ene-3,17-dione biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of androst-4-ene-3,17-dione biosynthetic process." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:24399684]
synonym: "activation of androst-4-ene-3,17-dione anabolism" NARROW [GOC:TermGenie]
synonym: "activation of androst-4-ene-3,17-dione biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of androst-4-ene-3,17-dione biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of androst-4-ene-3,17-dione formation" NARROW [GOC:TermGenie]
synonym: "activation of androst-4-ene-3,17-dione synthesis" NARROW [GOC:TermGenie]
synonym: "activation of androstenedione" NARROW [GOC:TermGenie]
synonym: "positive regulation of androst-4-ene-3,17-dione anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of androst-4-ene-3,17-dione biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of androst-4-ene-3,17-dione formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of androst-4-ene-3,17-dione synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of androstenedione" EXACT [GOC:TermGenie]
synonym: "up regulation of androst-4-ene-3,17-dione anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of androst-4-ene-3,17-dione biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of androst-4-ene-3,17-dione biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of androst-4-ene-3,17-dione formation" EXACT [GOC:TermGenie]
synonym: "up regulation of androst-4-ene-3,17-dione synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of androstenedione" EXACT [GOC:TermGenie]
synonym: "up-regulation of androst-4-ene-3,17-dione anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of androst-4-ene-3,17-dione biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of androst-4-ene-3,17-dione biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of androst-4-ene-3,17-dione formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of androst-4-ene-3,17-dione synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of androstenedione" EXACT [GOC:TermGenie]
synonym: "upregulation of androst-4-ene-3,17-dione anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of androst-4-ene-3,17-dione biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of androst-4-ene-3,17-dione biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of androst-4-ene-3,17-dione formation" EXACT [GOC:TermGenie]
synonym: "upregulation of androst-4-ene-3,17-dione synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of androstenedione" EXACT [GOC:TermGenie]
is_a: GO:0010893 ! positive regulation of steroid biosynthetic process
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:1903454 ! regulation of androst-4-ene-3,17-dione biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1903449 ! androst-4-ene-3,17-dione biosynthetic process
relationship: positively_regulates GO:1903449 ! androst-4-ene-3,17-dione biosynthetic process
created_by: mr
creation_date: 2014-09-22T14:37:07Z

[Term]
id: GO:1903457
name: lactate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lactate." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:8941775]
synonym: "lactate breakdown" EXACT [GOC:TermGenie]
synonym: "lactate catabolism" EXACT [GOC:TermGenie]
synonym: "lactate degradation" EXACT [GOC:TermGenie]
is_a: GO:0006089 ! lactate metabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
created_by: pr
creation_date: 2014-09-23T08:41:03Z

[Term]
id: GO:1903459
name: mitotic DNA replication lagging strand elongation
namespace: biological_process
def: "Any lagging strand elongation that is involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234]
synonym: "lagging strand elongation involved in DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "lagging strand elongation involved in DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "lagging strand elongation involved in DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "lagging strand elongation involved in mitotic DNA replication" EXACT []
synonym: "lagging strand elongation involved in mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "lagging strand elongation involved in nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie]
is_a: GO:0006273 ! lagging strand elongation
is_a: GO:1902983 ! DNA strand elongation involved in mitotic DNA replication
intersection_of: GO:0006273 ! lagging strand elongation
intersection_of: part_of GO:1902969 ! mitotic DNA replication
relationship: part_of GO:1902969 ! mitotic DNA replication
created_by: vw
creation_date: 2014-09-23T13:32:54Z

[Term]
id: GO:1903460
name: mitotic DNA replication leading strand elongation
namespace: biological_process
def: "Any leading strand elongation that is involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234]
synonym: "leading strand elongation involved in DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "leading strand elongation involved in DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "leading strand elongation involved in DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "leading strand elongation involved in mitotic DNA replication" EXACT []
synonym: "leading strand elongation involved in mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "leading strand elongation involved in nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie]
is_a: GO:0006272 ! leading strand elongation
is_a: GO:1902983 ! DNA strand elongation involved in mitotic DNA replication
intersection_of: GO:0006272 ! leading strand elongation
intersection_of: part_of GO:1902969 ! mitotic DNA replication
relationship: part_of GO:1902969 ! mitotic DNA replication
created_by: vw
creation_date: 2014-09-23T13:33:03Z

[Term]
id: GO:1903461
name: Okazaki fragment processing involved in mitotic DNA replication
namespace: biological_process
def: "Any DNA replication, Okazaki fragment processing that is involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234]
synonym: "DNA replication, Okazaki fragment processing involved in DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "DNA replication, Okazaki fragment processing involved in DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "DNA replication, Okazaki fragment processing involved in DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "DNA replication, Okazaki fragment processing involved in mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "DNA replication, Okazaki fragment processing involved in nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie]
is_a: GO:0033567 ! DNA replication, Okazaki fragment processing
is_a: GO:0044710 ! single-organism metabolic process
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0033567 ! DNA replication, Okazaki fragment processing
intersection_of: part_of GO:1902969 ! mitotic DNA replication
relationship: part_of GO:1902969 ! mitotic DNA replication
created_by: vw
creation_date: 2014-09-23T13:33:11Z

[Term]
id: GO:1903463
name: regulation of mitotic cell cycle DNA replication
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitotic cell cycle DNA replication." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234]
synonym: "regulation of DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "regulation of DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "regulation of DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "regulation of mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie]
is_a: GO:0007346 ! regulation of mitotic cell cycle
is_a: GO:0033262 ! regulation of nuclear cell cycle DNA replication
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1902969 ! mitotic DNA replication
relationship: regulates GO:1902969 ! mitotic DNA replication
created_by: vw
creation_date: 2014-09-23T13:38:25Z

[Term]
id: GO:1903464
name: negative regulation of mitotic cell cycle DNA replication
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cell cycle DNA replication." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234]
synonym: "down regulation of DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "down regulation of DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "down regulation of DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "down regulation of mitotic cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "down regulation of mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "down regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "down-regulation of DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "down-regulation of DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitotic cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "down-regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "downregulation of DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "downregulation of DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "downregulation of mitotic cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "downregulation of mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "downregulation of nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "inhibition of DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "inhibition of DNA replication involved in S phase involved in mitotic cell cycle" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA replication involved in S-phase involved in mitotic cell cycle" NARROW [GOC:TermGenie]
synonym: "inhibition of mitotic cell cycle DNA replication" NARROW [GOC:TermGenie]
synonym: "inhibition of mitotic nuclear cell cycle DNA replication" NARROW [GOC:TermGenie]
synonym: "inhibition of nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "negative regulation of DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "negative regulation of DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "negative regulation of DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "negative regulation of mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "negative regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie]
is_a: GO:0045930 ! negative regulation of mitotic cell cycle
is_a: GO:1902576 ! negative regulation of nuclear cell cycle DNA replication
is_a: GO:1903463 ! regulation of mitotic cell cycle DNA replication
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1902969 ! mitotic DNA replication
relationship: negatively_regulates GO:1902969 ! mitotic DNA replication
created_by: vw
creation_date: 2014-09-23T13:38:33Z

[Term]
id: GO:1903465
name: positive regulation of mitotic cell cycle DNA replication
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitotic cell cycle DNA replication." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234]
synonym: "activation of DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "activation of DNA replication involved in S phase involved in mitotic cell cycle" NARROW [GOC:TermGenie]
synonym: "activation of DNA replication involved in S-phase involved in mitotic cell cycle" NARROW [GOC:TermGenie]
synonym: "activation of mitotic cell cycle DNA replication" NARROW [GOC:TermGenie]
synonym: "activation of mitotic nuclear cell cycle DNA replication" NARROW [GOC:TermGenie]
synonym: "activation of nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "positive regulation of DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "positive regulation of DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "positive regulation of DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "positive regulation of mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "positive regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "up regulation of DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "up regulation of DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "up regulation of mitotic cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "up regulation of mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "up regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "up-regulation of DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "up-regulation of DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitotic cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "up-regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "upregulation of DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "upregulation of DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "upregulation of mitotic cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "upregulation of mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "upregulation of nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie]
is_a: GO:0010571 ! positive regulation of nuclear cell cycle DNA replication
is_a: GO:0045931 ! positive regulation of mitotic cell cycle
is_a: GO:1903463 ! regulation of mitotic cell cycle DNA replication
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1902969 ! mitotic DNA replication
relationship: positively_regulates GO:1902969 ! mitotic DNA replication
created_by: vw
creation_date: 2014-09-23T13:38:41Z

[Term]
id: GO:1903466
name: regulation of mitotic DNA replication initiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA replication initiation involved in mitotic DNA replication." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234]
synonym: "regulation of DNA replication initiation involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie]
is_a: GO:0030174 ! regulation of DNA-dependent DNA replication initiation
is_a: GO:1903463 ! regulation of mitotic cell cycle DNA replication
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1902975 ! mitotic DNA replication initiation
relationship: regulates GO:1902975 ! mitotic DNA replication initiation
created_by: vw
creation_date: 2014-09-23T13:38:49Z

[Term]
id: GO:1903467
name: negative regulation of mitotic DNA replication initiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA replication initiation involved in mitotic DNA replication." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234]
synonym: "down regulation of DNA replication initiation involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "down regulation of DNA replication initiation involved in mitotic DNA replication" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA replication initiation involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA replication initiation involved in mitotic DNA replication" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA replication initiation involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA replication initiation involved in mitotic DNA replication" EXACT [GOC:TermGenie]
synonym: "inhibition of DNA replication initiation involved in mitotic cell cycle DNA replication" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA replication initiation involved in mitotic DNA replication" NARROW [GOC:TermGenie]
synonym: "negative regulation of DNA replication initiation involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie]
is_a: GO:0032297 ! negative regulation of DNA-dependent DNA replication initiation
is_a: GO:1903464 ! negative regulation of mitotic cell cycle DNA replication
is_a: GO:1903466 ! regulation of mitotic DNA replication initiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1902975 ! mitotic DNA replication initiation
relationship: negatively_regulates GO:1902975 ! mitotic DNA replication initiation
created_by: vw
creation_date: 2014-09-23T13:38:58Z

[Term]
id: GO:1903468
name: positive regulation of DNA replication initiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA replication initiation involved in mitotic DNA replication." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234]
synonym: "activation of DNA replication initiation involved in mitotic cell cycle DNA replication" NARROW [GOC:TermGenie]
synonym: "activation of DNA replication initiation involved in mitotic DNA replication" NARROW [GOC:TermGenie]
synonym: "positive regulation of DNA replication initiation involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA replication initiation involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA replication initiation involved in mitotic DNA replication" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA replication initiation involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA replication initiation involved in mitotic DNA replication" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA replication initiation involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA replication initiation involved in mitotic DNA replication" EXACT [GOC:TermGenie]
is_a: GO:0032298 ! positive regulation of DNA-dependent DNA replication initiation
is_a: GO:1903465 ! positive regulation of mitotic cell cycle DNA replication
is_a: GO:1903466 ! regulation of mitotic DNA replication initiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1902975 ! mitotic DNA replication initiation
relationship: positively_regulates GO:1902975 ! mitotic DNA replication initiation
created_by: vw
creation_date: 2014-09-23T13:39:06Z

[Term]
id: GO:1903469
name: removal of RNA primer involved in mitotic DNA replication
namespace: biological_process
def: "Any DNA replication, removal of RNA primer that is involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234]
synonym: "DNA replication, removal of RNA primer involved in DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "DNA replication, removal of RNA primer involved in DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "DNA replication, removal of RNA primer involved in DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "DNA replication, removal of RNA primer involved in mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "DNA replication, removal of RNA primer involved in nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "Okazaki initiator RNA removal involved in DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "Okazaki initiator RNA removal involved in DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "Okazaki initiator RNA removal involved in DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "Okazaki initiator RNA removal involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "Okazaki initiator RNA removal involved in mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "Okazaki initiator RNA removal involved in nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie]
is_a: GO:0043137 ! DNA replication, removal of RNA primer
is_a: GO:0044712 ! single-organism catabolic process
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0043137 ! DNA replication, removal of RNA primer
intersection_of: part_of GO:1902969 ! mitotic DNA replication
relationship: part_of GO:1902969 ! mitotic DNA replication
created_by: vw
creation_date: 2014-09-23T13:42:24Z

[Term]
id: GO:1903470
name: obsolete actomyosin contractile ring assembly involved in mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any actomyosin contractile ring assembly that is involved in mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "constriction ring assembly involved in mitotic cell cycle" NARROW [GOC:TermGenie]
synonym: "contractile ring assembly involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "cytokinesis, actomyosin contractile ring assembly involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "cytokinesis, actomyosin contractile ring formation involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "cytokinesis, actomyosin ring biosynthesis involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "cytokinesis, actomyosin ring formation involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "cytokinesis, contractile ring assembly involved in mitotic cell cycle" RELATED [GOC:TermGenie]
is_obsolete: true
created_by: vw
creation_date: 2014-09-23T14:06:50Z

[Term]
id: GO:1903471
name: regulation of mitotic actomyosin contractile ring contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitotic actomyosin contractile ring contraction." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234]
synonym: "regulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "regulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle" EXACT [GOC:TermGenie]
is_a: GO:0031991 ! regulation of actomyosin contractile ring contraction
is_a: GO:1903436 ! regulation of mitotic cytokinetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1902404 ! mitotic actomyosin contractile ring contraction
relationship: regulates GO:1902404 ! mitotic actomyosin contractile ring contraction
created_by: vw
creation_date: 2014-09-23T14:10:22Z

[Term]
id: GO:1903472
name: negative regulation of mitotic actomyosin contractile ring contraction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic actomyosin contractile ring contraction." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234]
synonym: "down regulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "down regulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "down regulation of mitotic actomyosin contractile ring contraction" EXACT [GOC:TermGenie]
synonym: "down-regulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "down-regulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitotic actomyosin contractile ring contraction" EXACT [GOC:TermGenie]
synonym: "downregulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "downregulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "downregulation of mitotic actomyosin contractile ring contraction" EXACT [GOC:TermGenie]
synonym: "inhibition of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle" NARROW [GOC:TermGenie]
synonym: "inhibition of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle" NARROW [GOC:TermGenie]
synonym: "inhibition of mitotic actomyosin contractile ring contraction" NARROW [GOC:TermGenie]
synonym: "negative regulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "negative regulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle" EXACT [GOC:TermGenie]
is_a: GO:1903437 ! negative regulation of mitotic cytokinetic process
is_a: GO:1903471 ! regulation of mitotic actomyosin contractile ring contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1902404 ! mitotic actomyosin contractile ring contraction
relationship: negatively_regulates GO:1902404 ! mitotic actomyosin contractile ring contraction
created_by: vw
creation_date: 2014-09-23T14:10:38Z

[Term]
id: GO:1903473
name: positive regulation of mitotic actomyosin contractile ring contraction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitotic actomyosin contractile ring contraction." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234]
synonym: "activation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle" NARROW [GOC:TermGenie]
synonym: "activation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle" NARROW [GOC:TermGenie]
synonym: "activation of mitotic actomyosin contractile ring contraction" NARROW [GOC:TermGenie]
synonym: "positive regulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "positive regulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "up regulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "up regulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "up regulation of mitotic actomyosin contractile ring contraction" EXACT [GOC:TermGenie]
synonym: "up-regulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "up-regulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitotic actomyosin contractile ring contraction" EXACT [GOC:TermGenie]
synonym: "upregulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "upregulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "upregulation of mitotic actomyosin contractile ring contraction" EXACT [GOC:TermGenie]
is_a: GO:1903438 ! positive regulation of mitotic cytokinetic process
is_a: GO:1903471 ! regulation of mitotic actomyosin contractile ring contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1902404 ! mitotic actomyosin contractile ring contraction
relationship: positively_regulates GO:1902404 ! mitotic actomyosin contractile ring contraction
created_by: vw
creation_date: 2014-09-23T14:10:46Z

[Term]
id: GO:1903474
name: maintenance of mitotic actomyosin contractile ring localization
namespace: biological_process
def: "Any maintenance of actomyosin contractile ring localization that is involved in mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:12345]
synonym: "cytokinetic ring anchoring involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle" RELATED [GOC:TermGenie]
is_a: GO:0032189 ! maintenance of actomyosin contractile ring localization
is_a: GO:1902405 ! mitotic actomyosin contractile ring localization
intersection_of: GO:0032189 ! maintenance of actomyosin contractile ring localization
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0000278 ! mitotic cell cycle
created_by: vw
creation_date: 2014-09-23T14:12:48Z

[Term]
id: GO:1903475
name: mitotic actomyosin contractile ring assembly
namespace: biological_process
def: "Any actomyosin contractile ring assembly that is involved in mitotic cytokinesis." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "actomyosin contractile ring assembly involved in cytokinesis after mitosis" EXACT [GOC:TermGenie]
synonym: "contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
is_a: GO:0000915 ! actomyosin contractile ring assembly
is_a: GO:1902407 ! assembly of actomyosin apparatus involved in mitotic cytokinesis
intersection_of: GO:0000915 ! actomyosin contractile ring assembly
intersection_of: part_of GO:0000281 ! mitotic cytokinesis
relationship: part_of GO:0000281 ! mitotic cytokinesis
created_by: vw
creation_date: 2014-09-23T14:42:12Z

[Term]
id: GO:1903476
name: protein localization to cell division site involved in mitotic actomyosin contractile ring assembly
namespace: biological_process
def: "Any protein localization to cell division site that is involved in mitotic actomyosin contractile ring assembly." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "protein localisation to cell division site involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie]
synonym: "protein localization to cell division site involved in actomyosin contractile ring assembly involved in cytokinesis after mitosis" EXACT [GOC:TermGenie]
synonym: "protein localization to cell division site involved in contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
is_a: GO:1902575 ! protein localization to cell division site involved in cytokinesis, actomyosin contractile ring assembly
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0072741 ! protein localization to cell division site
intersection_of: part_of GO:1903475 ! mitotic actomyosin contractile ring assembly
relationship: part_of GO:1903475 ! mitotic actomyosin contractile ring assembly
created_by: vw
creation_date: 2014-09-23T14:52:37Z

[Term]
id: GO:1903477
name: mitotic contractile ring actin filament bundle assembly
namespace: biological_process
def: "Any actin filament bundle assembly that is involved in mitotic actomyosin contractile ring assembly." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie, GOC:vw]
synonym: "actin filament bundle assembly involved in mitotic actomyosin contractile ring assembly" EXACT []
is_a: GO:0071519 ! actomyosin contractile ring actin filament bundle assembly
is_a: GO:1903479 ! mitotic actomyosin contractile ring assembly actin filament organization
intersection_of: GO:0051017 ! actin filament bundle assembly
intersection_of: part_of GO:1903475 ! mitotic actomyosin contractile ring assembly
relationship: part_of GO:1903475 ! mitotic actomyosin contractile ring assembly
created_by: vw
creation_date: 2014-09-23T14:56:01Z

[Term]
id: GO:1903478
name: actin filament bundle convergence involved in mitotic contractile ring assembly
namespace: biological_process
def: "Any actin filament bundle convergence that is involved in mitotic actomyosin contractile ring assembly." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie, GOC:vw]
synonym: "actin filament bundle convergence involved in actomyosin contractile ring assembly involved in cytokinesis after mitosis" EXACT [GOC:TermGenie]
synonym: "actin filament bundle convergence involved in contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "actin filament bundle convergence involved in cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "actin filament bundle convergence involved in mitotic actomyosin contractile ring assembly" EXACT []
is_a: GO:0071520 ! actomyosin contractile ring assembly actin filament bundle convergence
is_a: GO:1903479 ! mitotic actomyosin contractile ring assembly actin filament organization
intersection_of: GO:0090426 ! actin filament bundle convergence
intersection_of: part_of GO:1903475 ! mitotic actomyosin contractile ring assembly
relationship: part_of GO:1903475 ! mitotic actomyosin contractile ring assembly
created_by: vw
creation_date: 2014-09-23T15:03:11Z

[Term]
id: GO:1903479
name: mitotic actomyosin contractile ring assembly actin filament organization
namespace: biological_process
def: "Any actin filament organization that is involved in mitotic actomyosin contractile ring assembly." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "actin filament organisation involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie]
synonym: "actin filament organization involved in mitotic actomyosin contractile ring assembly" EXACT []
is_a: GO:1903047 ! mitotic cell cycle process
is_a: GO:2000689 ! actomyosin contractile ring assembly actin filament organization
intersection_of: GO:0007015 ! actin filament organization
intersection_of: part_of GO:1903475 ! mitotic actomyosin contractile ring assembly
relationship: part_of GO:1903475 ! mitotic actomyosin contractile ring assembly
created_by: vw
creation_date: 2014-09-23T15:03:19Z

[Term]
id: GO:1903480
name: regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of actin filament organization involved in mitotic actomyosin contractile ring assembly." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "regulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "regulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie]
is_a: GO:1903117 ! regulation of actin filament organization involved in cytokinetic actomyosin contractile ring assembly
is_a: GO:1903499 ! regulation of mitotic actomyosin contractile ring assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1903479 ! mitotic actomyosin contractile ring assembly actin filament organization
relationship: regulates GO:1903479 ! mitotic actomyosin contractile ring assembly actin filament organization
created_by: vw
creation_date: 2014-09-23T16:03:42Z

[Term]
id: GO:1903481
name: negative regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of actin filament organization involved in mitotic actomyosin contractile ring assembly." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "down regulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "down regulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "downregulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of actin filament organization involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis" NARROW [GOC:TermGenie]
synonym: "inhibition of actin filament organisation involved in mitotic actomyosin contractile ring assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of actin filament organization involved in mitotic actomyosin contractile ring assembly" NARROW [GOC:TermGenie]
synonym: "negative regulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie]
is_a: GO:1903480 ! regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly
is_a: GO:1903500 ! negative regulation of mitotic actomyosin contractile ring assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1903479 ! mitotic actomyosin contractile ring assembly actin filament organization
relationship: negatively_regulates GO:1903479 ! mitotic actomyosin contractile ring assembly actin filament organization
created_by: vw
creation_date: 2014-09-23T16:03:50Z

[Term]
id: GO:1903482
name: positive regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of actin filament organization involved in mitotic actomyosin contractile ring assembly." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "activation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis" NARROW [GOC:TermGenie]
synonym: "activation of actin filament organisation involved in mitotic actomyosin contractile ring assembly" NARROW [GOC:TermGenie]
synonym: "activation of actin filament organization involved in mitotic actomyosin contractile ring assembly" NARROW [GOC:TermGenie]
synonym: "positive regulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "up regulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "upregulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of actin filament organization involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie]
is_a: GO:1903480 ! regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly
is_a: GO:1903501 ! positive regulation of mitotic actomyosin contractile ring assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1903479 ! mitotic actomyosin contractile ring assembly actin filament organization
relationship: positively_regulates GO:1903479 ! mitotic actomyosin contractile ring assembly actin filament organization
created_by: vw
creation_date: 2014-09-23T16:03:59Z

[Term]
id: GO:1903483
name: regulation of maintenance of mitotic actomyosin contractile ring localization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of maintenance of mitotic actomyosin contractile ring localization." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "regulation of cytokinetic ring anchoring involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "regulation of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "regulation of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "regulation of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle" RELATED [GOC:TermGenie]
is_a: GO:0051128 ! regulation of cellular component organization
is_a: GO:1902471 ! regulation of mitotic actomyosin contractile ring localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1903474 ! maintenance of mitotic actomyosin contractile ring localization
relationship: regulates GO:1903474 ! maintenance of mitotic actomyosin contractile ring localization
created_by: vw
creation_date: 2014-09-23T16:12:19Z

[Term]
id: GO:1903484
name: negative regulation of maintenance of mitotic actomyosin contractile ring localization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of mitotic actomyosin contractile ring localization." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "down regulation of cytokinetic ring anchoring involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "down regulation of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "down regulation of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "down regulation of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "down regulation of maintenance of mitotic actomyosin contractile ring localization" EXACT [GOC:TermGenie]
synonym: "down-regulation of cytokinetic ring anchoring involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "down-regulation of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "down-regulation of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "down-regulation of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "down-regulation of maintenance of mitotic actomyosin contractile ring localization" EXACT [GOC:TermGenie]
synonym: "downregulation of cytokinetic ring anchoring involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "downregulation of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "downregulation of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "downregulation of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "downregulation of maintenance of mitotic actomyosin contractile ring localization" EXACT [GOC:TermGenie]
synonym: "inhibition of cytokinetic ring anchoring involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "inhibition of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle" NARROW [GOC:TermGenie]
synonym: "inhibition of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle" NARROW [GOC:TermGenie]
synonym: "inhibition of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "inhibition of maintenance of mitotic actomyosin contractile ring localization" NARROW [GOC:TermGenie]
synonym: "negative regulation of cytokinetic ring anchoring involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "negative regulation of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "negative regulation of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "negative regulation of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle" RELATED [GOC:TermGenie]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1901649 ! negative regulation of actomyosin contractile ring localization
is_a: GO:1903437 ! negative regulation of mitotic cytokinetic process
is_a: GO:1903483 ! regulation of maintenance of mitotic actomyosin contractile ring localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1903474 ! maintenance of mitotic actomyosin contractile ring localization
relationship: negatively_regulates GO:1903474 ! maintenance of mitotic actomyosin contractile ring localization
created_by: vw
creation_date: 2014-09-23T16:12:28Z

[Term]
id: GO:1903485
name: positive regulation of maintenance of mitotic actomyosin contractile ring localization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of maintenance of mitotic actomyosin contractile ring localization." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "activation of cytokinetic ring anchoring involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "activation of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle" NARROW [GOC:TermGenie]
synonym: "activation of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle" NARROW [GOC:TermGenie]
synonym: "activation of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "activation of maintenance of mitotic actomyosin contractile ring localization" NARROW [GOC:TermGenie]
synonym: "positive regulation of cytokinetic ring anchoring involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "positive regulation of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "positive regulation of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "positive regulation of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "up regulation of cytokinetic ring anchoring involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "up regulation of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "up regulation of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "up regulation of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "up regulation of maintenance of mitotic actomyosin contractile ring localization" EXACT [GOC:TermGenie]
synonym: "up-regulation of cytokinetic ring anchoring involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "up-regulation of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "up-regulation of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "up-regulation of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "up-regulation of maintenance of mitotic actomyosin contractile ring localization" EXACT [GOC:TermGenie]
synonym: "upregulation of cytokinetic ring anchoring involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "upregulation of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "upregulation of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "upregulation of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "upregulation of maintenance of mitotic actomyosin contractile ring localization" EXACT [GOC:TermGenie]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1901650 ! positive regulation of actomyosin contractile ring localization
is_a: GO:1903438 ! positive regulation of mitotic cytokinetic process
is_a: GO:1903483 ! regulation of maintenance of mitotic actomyosin contractile ring localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1903474 ! maintenance of mitotic actomyosin contractile ring localization
relationship: positively_regulates GO:1903474 ! maintenance of mitotic actomyosin contractile ring localization
created_by: vw
creation_date: 2014-09-23T16:12:37Z

[Term]
id: GO:1903486
name: establishment of mitotic actomyosin contractile ring localization
namespace: biological_process
def: "Any establishment of actomyosin contractile ring localization that is involved in mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "establishment of actomyosin contractile ring localization involved in mitotic cell cycle" EXACT []
is_a: GO:0032188 ! establishment of actomyosin contractile ring localization
is_a: GO:1902405 ! mitotic actomyosin contractile ring localization
intersection_of: GO:0032188 ! establishment of actomyosin contractile ring localization
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0000278 ! mitotic cell cycle
created_by: vw
creation_date: 2014-09-23T16:17:09Z

[Term]
id: GO:1903487
name: regulation of lactation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lactation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:19563620]
is_a: GO:0050878 ! regulation of body fluid levels
is_a: GO:0051046 ! regulation of secretion
is_a: GO:2000026 ! regulation of multicellular organismal development
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007595 ! lactation
relationship: regulates GO:0007595 ! lactation
created_by: mr
creation_date: 2014-09-24T14:44:13Z

[Term]
id: GO:1903488
name: negative regulation of lactation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lactation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:19563620]
synonym: "down regulation of lactation" EXACT [GOC:TermGenie]
synonym: "down-regulation of lactation" EXACT [GOC:TermGenie]
synonym: "downregulation of lactation" EXACT [GOC:TermGenie]
synonym: "inhibition of lactation" NARROW [GOC:TermGenie]
is_a: GO:0051048 ! negative regulation of secretion
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1903487 ! regulation of lactation
is_a: GO:2000242 ! negative regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007595 ! lactation
relationship: negatively_regulates GO:0007595 ! lactation
created_by: mr
creation_date: 2014-09-24T14:44:22Z

[Term]
id: GO:1903489
name: positive regulation of lactation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lactation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:19563620]
synonym: "activation of lactation" NARROW [GOC:TermGenie]
synonym: "up regulation of lactation" EXACT [GOC:TermGenie]
synonym: "up-regulation of lactation" EXACT [GOC:TermGenie]
synonym: "upregulation of lactation" EXACT [GOC:TermGenie]
is_a: GO:0051047 ! positive regulation of secretion
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1903487 ! regulation of lactation
is_a: GO:2000243 ! positive regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007595 ! lactation
relationship: positively_regulates GO:0007595 ! lactation
created_by: mr
creation_date: 2014-09-24T14:44:30Z

[Term]
id: GO:1903490
name: positive regulation of mitotic cytokinesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitotic cytokinesis." [GO_REF:0000058, GOC:TermGenie, PMID:24920823]
synonym: "activation of cytokinesis after mitosis" NARROW [GOC:TermGenie]
synonym: "activation of mitotic cytokinesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of cytokinesis after mitosis" EXACT [GOC:TermGenie]
synonym: "up regulation of cytokinesis after mitosis" EXACT [GOC:TermGenie]
synonym: "up regulation of mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of cytokinesis after mitosis" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "upregulation of cytokinesis after mitosis" EXACT [GOC:TermGenie]
synonym: "upregulation of mitotic cytokinesis" EXACT [GOC:TermGenie]
is_a: GO:0032467 ! positive regulation of cytokinesis
is_a: GO:0045931 ! positive regulation of mitotic cell cycle
is_a: GO:1902412 ! regulation of mitotic cytokinesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000281 ! mitotic cytokinesis
relationship: positively_regulates GO:0000281 ! mitotic cytokinesis
created_by: al
creation_date: 2014-09-25T09:00:35Z

[Term]
id: GO:1903491
name: response to simvastatin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a simvastatin stimulus. Simvastatin is a statin used as a cholesterol-lowering and anti-cardiovascular disease drug." [GO_REF:0000071, GOC:sl, GOC:TermGenie, PMID:23100282]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033993 ! response to lipid
is_a: GO:0036273 ! response to statin
created_by: hp
creation_date: 2014-09-25T10:58:06Z

[Term]
id: GO:1903492
name: response to acetylsalicylate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aspirin (acetylsalicylate) stimulus. Aspirin is a non-steroidal anti-inflammatory drug with moA cyclooxygenase inhibitor activity." [GO_REF:0000071, GOC:TermGenie, PMID:23392654]
is_a: GO:0001101 ! response to acid chemical
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: hp
creation_date: 2014-09-25T10:58:23Z

[Term]
id: GO:1903493
name: response to clopidogrel
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a clopidogrel stimulus. Clopidogrel is a is an oral, thienopyridine-class antiplatelet agent used to inhibit blood clots in coronary artery disease, peripheral vascular disease, and cerebrovascular disease." [GO_REF:0000071, GOC:TermGenie, PMID:23392654]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: hp
creation_date: 2014-09-25T11:36:42Z

[Term]
id: GO:1903494
name: response to dehydroepiandrosterone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dehydroepiandrosterone stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:3585228]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033993 ! response to lipid
is_a: GO:0097305 ! response to alcohol
is_a: GO:1901654 ! response to ketone
created_by: mr
creation_date: 2014-09-25T17:01:18Z

[Term]
id: GO:1903495
name: cellular response to dehydroepiandrosterone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dehydroepiandrosterone stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:3585228]
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0097306 ! cellular response to alcohol
is_a: GO:1901655 ! cellular response to ketone
is_a: GO:1903494 ! response to dehydroepiandrosterone
created_by: mr
creation_date: 2014-09-25T17:01:26Z

[Term]
id: GO:1903496
name: response to 11-deoxycorticosterone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 11-deoxycorticosterone stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:3585228]
is_a: GO:0051385 ! response to mineralocorticoid
is_a: GO:0097305 ! response to alcohol
is_a: GO:1901654 ! response to ketone
created_by: mr
creation_date: 2014-09-25T17:01:35Z

[Term]
id: GO:1903497
name: cellular response to 11-deoxycorticosterone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 11-deoxycorticosterone stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:3585228]
is_a: GO:0071389 ! cellular response to mineralocorticoid stimulus
is_a: GO:0097306 ! cellular response to alcohol
is_a: GO:1901655 ! cellular response to ketone
is_a: GO:1903496 ! response to 11-deoxycorticosterone
created_by: mr
creation_date: 2014-09-25T17:01:43Z

[Term]
id: GO:1903498
name: bundle sheath cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a bundle sheath cell." [GO_REF:0000086, GOC:tb, GOC:TermGenie, PMID:24517883]
is_a: GO:0030154 ! cell differentiation
created_by: tb
creation_date: 2014-09-26T01:31:04Z

[Term]
id: GO:1903499
name: regulation of mitotic actomyosin contractile ring assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitotic actomyosin contractile ring assembly." [GO_REF:0000058, GOC:al, GOC:mtg_cell_cycle, GOC:TermGenie, GOC:vw, PMID:18256290]
synonym: "regulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis" EXACT [GOC:TermGenie]
synonym: "regulation of contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "regulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "regulation of mitotic cytokinesis, actomyosin contractile ring assembly" EXACT []
is_a: GO:1903436 ! regulation of mitotic cytokinetic process
is_a: GO:2000431 ! regulation of cytokinesis, actomyosin contractile ring assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1903475 ! mitotic actomyosin contractile ring assembly
relationship: regulates GO:1903475 ! mitotic actomyosin contractile ring assembly
created_by: pr
creation_date: 2014-09-30T10:13:50Z

[Term]
id: GO:1903500
name: negative regulation of mitotic actomyosin contractile ring assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic actomyosin contractile ring assembly." [GO_REF:0000058, GOC:al, GOC:mtg_cell_cycle, GOC:TermGenie, GOC:vw, PMID:18256290]
synonym: "down regulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis" EXACT [GOC:TermGenie]
synonym: "down regulation of contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "down regulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "down regulation of mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis" EXACT [GOC:TermGenie]
synonym: "downregulation of contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "downregulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "downregulation of mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of actomyosin contractile ring assembly involved in cytokinesis after mitosis" NARROW [GOC:TermGenie]
synonym: "inhibition of contractile ring assembly involved in mitotic cytokinesis" NARROW [GOC:TermGenie]
synonym: "inhibition of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis" NARROW [GOC:TermGenie]
synonym: "inhibition of mitotic actomyosin contractile ring assembly" NARROW [GOC:TermGenie]
synonym: "negative regulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis" EXACT [GOC:TermGenie]
synonym: "negative regulation of contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of mitotic cytokinesis, actomyosin contractile ring assembly" EXACT []
is_a: GO:1903437 ! negative regulation of mitotic cytokinetic process
is_a: GO:1903499 ! regulation of mitotic actomyosin contractile ring assembly
is_a: GO:2000432 ! negative regulation of cytokinesis, actomyosin contractile ring assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1903475 ! mitotic actomyosin contractile ring assembly
relationship: negatively_regulates GO:1903475 ! mitotic actomyosin contractile ring assembly
created_by: pr
creation_date: 2014-09-30T10:13:59Z

[Term]
id: GO:1903501
name: positive regulation of mitotic actomyosin contractile ring assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitotic actomyosin contractile ring assembly." [GO_REF:0000058, GOC:al, GOC:mtg_cell_cycle, GOC:TermGenie, GOC:vw, PMID:18256290]
synonym: "activation of actomyosin contractile ring assembly involved in cytokinesis after mitosis" NARROW [GOC:TermGenie]
synonym: "activation of contractile ring assembly involved in mitotic cytokinesis" NARROW [GOC:TermGenie]
synonym: "activation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis" NARROW [GOC:TermGenie]
synonym: "activation of mitotic actomyosin contractile ring assembly" NARROW [GOC:TermGenie]
synonym: "positive regulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis" EXACT [GOC:TermGenie]
synonym: "positive regulation of contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of mitotic cytokinesis, actomyosin contractile ring assembly" EXACT []
synonym: "up regulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis" EXACT [GOC:TermGenie]
synonym: "up regulation of contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "up regulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "up regulation of mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis" EXACT [GOC:TermGenie]
synonym: "up-regulation of contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis" EXACT [GOC:TermGenie]
synonym: "upregulation of contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "upregulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "upregulation of mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie]
is_a: GO:1903438 ! positive regulation of mitotic cytokinetic process
is_a: GO:1903499 ! regulation of mitotic actomyosin contractile ring assembly
is_a: GO:2000433 ! positive regulation of cytokinesis, actomyosin contractile ring assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1903475 ! mitotic actomyosin contractile ring assembly
relationship: positively_regulates GO:1903475 ! mitotic actomyosin contractile ring assembly
created_by: pr
creation_date: 2014-09-30T10:14:07Z

[Term]
id: GO:1903502
name: translation repressor complex
namespace: cellular_component
def: "A protein complex which is capable of translation repressor activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:14723848]
comment: An example of this is Eif4e in drome (P48598) in PMID:14723848 (inferred from physical interaction).
is_a: GO:0043234 ! protein complex
created_by: bhm
creation_date: 2014-09-30T12:44:27Z

[Term]
id: GO:1903503
name: ATPase inhibitor complex
namespace: cellular_component
def: "A protein complex which is capable of ATPase inhibitor activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:16170325]
comment: An example of this is Mago in drome (P49028) in PMID:16170325 (inferred from direct assay).
is_a: GO:0043234 ! protein complex
created_by: bhm
creation_date: 2014-09-30T13:55:37Z

[Term]
id: GO:1903504
name: regulation of mitotic spindle checkpoint
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitotic spindle checkpoint." [GO_REF:0000058, GOC:TermGenie, PMID:23442800]
comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of spindle checkpoint (assembly, orientation or Dma1-dependent).
subset: gocheck_do_not_manually_annotate
synonym: "regulation of mitotic cell cycle spindle checkpoint" EXACT [GOC:TermGenie]
is_a: GO:0030071 ! regulation of mitotic metaphase/anaphase transition
is_a: GO:0032434 ! regulation of proteasomal ubiquitin-dependent protein catabolic process
is_a: GO:0090231 ! regulation of spindle checkpoint
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071174 ! mitotic spindle checkpoint
relationship: regulates GO:0071174 ! mitotic spindle checkpoint
created_by: al
creation_date: 2014-10-01T13:52:57Z

[Term]
id: GO:1903505
name: regulation of establishment of actomyosin contractile ring localization involved in mitotic cell cycle
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of establishment of actomyosin contractile ring localization involved in mitotic cell cycle." [GO_REF:0000058, GOC:TermGenie, PMID:24165938]
is_a: GO:0071342 ! regulation of establishment of actomyosin contractile ring localization
is_a: GO:1902471 ! regulation of mitotic actomyosin contractile ring localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1903486 ! establishment of mitotic actomyosin contractile ring localization
relationship: regulates GO:1903486 ! establishment of mitotic actomyosin contractile ring localization
created_by: al
creation_date: 2014-10-01T13:59:19Z

[Term]
id: GO:1903506
name: regulation of nucleic acid-templated transcription
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nucleic acid-templated transcription." [GO_REF:0000058, GOC:pr, GOC:TermGenie, GOC:txnOH, GOC:vw]
is_a: GO:2001141 ! regulation of RNA biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097659 ! nucleic acid-templated transcription
relationship: regulates GO:0097659 ! nucleic acid-templated transcription
created_by: pr
creation_date: 2014-10-01T14:44:47Z

[Term]
id: GO:1903507
name: negative regulation of nucleic acid-templated transcription
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of nucleic acid-templated transcription." [GO_REF:0000058, GOC:pr, GOC:TermGenie, GOC:txnOH, GOC:vw]
synonym: "down regulation of nucleic acid-templated transcription" EXACT [GOC:TermGenie]
synonym: "down-regulation of nucleic acid-templated transcription" EXACT [GOC:TermGenie]
synonym: "downregulation of nucleic acid-templated transcription" EXACT [GOC:TermGenie]
synonym: "inhibition of nucleic acid-templated transcription" NARROW [GOC:TermGenie]
is_a: GO:1902679 ! negative regulation of RNA biosynthetic process
is_a: GO:1903506 ! regulation of nucleic acid-templated transcription
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097659 ! nucleic acid-templated transcription
relationship: negatively_regulates GO:0097659 ! nucleic acid-templated transcription
created_by: pr
creation_date: 2014-10-01T14:44:56Z

[Term]
id: GO:1903508
name: positive regulation of nucleic acid-templated transcription
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of nucleic acid-templated transcription." [GO_REF:0000058, GOC:pr, GOC:TermGenie, GOC:txnOH, GOC:vw]
synonym: "activation of nucleic acid-templated transcription" NARROW [GOC:TermGenie]
synonym: "up regulation of nucleic acid-templated transcription" EXACT [GOC:TermGenie]
synonym: "up-regulation of nucleic acid-templated transcription" EXACT [GOC:TermGenie]
synonym: "upregulation of nucleic acid-templated transcription" EXACT [GOC:TermGenie]
is_a: GO:1902680 ! positive regulation of RNA biosynthetic process
is_a: GO:1903506 ! regulation of nucleic acid-templated transcription
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097659 ! nucleic acid-templated transcription
relationship: positively_regulates GO:0097659 ! nucleic acid-templated transcription
created_by: pr
creation_date: 2014-10-01T14:45:04Z

[Term]
id: GO:1903509
name: liposaccharide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving liposaccharide." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:9452964]
synonym: "liposaccharide metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006629 ! lipid metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process
created_by: dph
creation_date: 2014-10-01T21:52:52Z

[Term]
id: GO:1903510
name: mucopolysaccharide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mucopolysaccharide." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:4236091]
synonym: "mucopolysaccharide metabolism" EXACT [GOC:TermGenie]
is_a: GO:0030203 ! glycosaminoglycan metabolic process
created_by: dph
creation_date: 2014-10-01T21:55:47Z

[Term]
id: GO:1903511
name: orotic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving orotic acid." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:10727948]
synonym: "orotic acid metabolism" EXACT [GOC:TermGenie]
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0072527 ! pyrimidine-containing compound metabolic process
created_by: dph
creation_date: 2014-10-01T21:58:06Z

[Term]
id: GO:1903512
name: phytanic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phytanic acid." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:16799769]
synonym: "phytanic acid metabolism" EXACT [GOC:TermGenie]
is_a: GO:0001676 ! long-chain fatty acid metabolic process
is_a: GO:0097089 ! methyl-branched fatty acid metabolic process
created_by: dph
creation_date: 2014-10-01T22:00:29Z

[Term]
id: GO:1903513
name: endoplasmic reticulum to cytosol transport
namespace: biological_process
def: "The directed movement of substances from endoplasmic reticulum to cytosol." [GO_REF:0000076, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:16402920]
synonym: "ER to cytosol transport" EXACT [GOC:TermGenie]
is_a: GO:0046907 ! intracellular transport
created_by: rl
creation_date: 2014-10-02T11:24:34Z

[Term]
id: GO:1903514
name: calcium ion transport from endoplasmic reticulum to cytosol
namespace: biological_process
def: "The directed movement of calcium ion from endoplasmic reticulum to cytosol." [GO_REF:0000078, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:16402920]
is_a: GO:0060402 ! calcium ion transport into cytosol
is_a: GO:1903513 ! endoplasmic reticulum to cytosol transport
created_by: rl
creation_date: 2014-10-02T11:30:34Z

[Term]
id: GO:1903515
name: calcium ion transport from cytosol to endoplasmic reticulum
namespace: biological_process
def: "The directed movement of calcium ion from cytosol to endoplasmic reticulum." [GO_REF:0000078, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:16402920]
is_a: GO:0060401 ! cytosolic calcium ion transport
created_by: rl
creation_date: 2014-10-02T14:51:20Z

[Term]
id: GO:1903516
name: regulation of single strand break repair
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of single strand break repair." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17395247]
is_a: GO:0006282 ! regulation of DNA repair
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000012 ! single strand break repair
relationship: regulates GO:0000012 ! single strand break repair
created_by: rl
creation_date: 2014-10-06T10:58:52Z

[Term]
id: GO:1903517
name: negative regulation of single strand break repair
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of single strand break repair." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17395247]
synonym: "down regulation of single strand break repair" EXACT [GOC:TermGenie]
synonym: "down-regulation of single strand break repair" EXACT [GOC:TermGenie]
synonym: "downregulation of single strand break repair" EXACT [GOC:TermGenie]
synonym: "inhibition of single strand break repair" NARROW [GOC:TermGenie]
is_a: GO:0045738 ! negative regulation of DNA repair
is_a: GO:1903516 ! regulation of single strand break repair
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000012 ! single strand break repair
relationship: negatively_regulates GO:0000012 ! single strand break repair
created_by: rl
creation_date: 2014-10-06T10:59:01Z

[Term]
id: GO:1903518
name: positive regulation of single strand break repair
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of single strand break repair." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17395247]
synonym: "activation of single strand break repair" NARROW [GOC:TermGenie]
synonym: "up regulation of single strand break repair" EXACT [GOC:TermGenie]
synonym: "up-regulation of single strand break repair" EXACT [GOC:TermGenie]
synonym: "upregulation of single strand break repair" EXACT [GOC:TermGenie]
is_a: GO:0045739 ! positive regulation of DNA repair
is_a: GO:1903516 ! regulation of single strand break repair
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000012 ! single strand break repair
relationship: positively_regulates GO:0000012 ! single strand break repair
created_by: rl
creation_date: 2014-10-06T10:59:10Z

[Term]
id: GO:1903519
name: regulation of mammary gland involution
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mammary gland involution." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:23164222]
is_a: GO:0034103 ! regulation of tissue remodeling
is_a: GO:2000027 ! regulation of organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060056 ! mammary gland involution
relationship: regulates GO:0060056 ! mammary gland involution
created_by: dph
creation_date: 2014-10-06T12:01:22Z

[Term]
id: GO:1903520
name: negative regulation of mammary gland involution
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mammary gland involution." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:23164222]
synonym: "down regulation of mammary gland involution" EXACT [GOC:TermGenie]
synonym: "down-regulation of mammary gland involution" EXACT [GOC:TermGenie]
synonym: "downregulation of mammary gland involution" EXACT [GOC:TermGenie]
synonym: "inhibition of mammary gland involution" NARROW [GOC:TermGenie]
is_a: GO:0034104 ! negative regulation of tissue remodeling
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:1903519 ! regulation of mammary gland involution
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060056 ! mammary gland involution
relationship: negatively_regulates GO:0060056 ! mammary gland involution
created_by: dph
creation_date: 2014-10-06T12:01:30Z

[Term]
id: GO:1903521
name: positive regulation of mammary gland involution
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mammary gland involution." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:23164222]
synonym: "activation of mammary gland involution" NARROW [GOC:TermGenie]
synonym: "up regulation of mammary gland involution" EXACT [GOC:TermGenie]
synonym: "up-regulation of mammary gland involution" EXACT [GOC:TermGenie]
synonym: "upregulation of mammary gland involution" EXACT [GOC:TermGenie]
is_a: GO:0034105 ! positive regulation of tissue remodeling
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:1903519 ! regulation of mammary gland involution
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060056 ! mammary gland involution
relationship: positively_regulates GO:0060056 ! mammary gland involution
created_by: dph
creation_date: 2014-10-06T12:01:39Z

[Term]
id: GO:1903522
name: regulation of blood circulation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of blood circulation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10659969]
synonym: "regulation of hemolymph circulation" RELATED [GOC:TermGenie]
is_a: GO:0044057 ! regulation of system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008015 ! blood circulation
relationship: regulates GO:0008015 ! blood circulation
created_by: mr
creation_date: 2014-10-06T18:38:56Z

[Term]
id: GO:1903523
name: negative regulation of blood circulation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of blood circulation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10659969]
synonym: "down regulation of blood circulation" EXACT [GOC:TermGenie]
synonym: "down regulation of hemolymph circulation" RELATED [GOC:TermGenie]
synonym: "down-regulation of blood circulation" EXACT [GOC:TermGenie]
synonym: "down-regulation of hemolymph circulation" RELATED [GOC:TermGenie]
synonym: "downregulation of blood circulation" EXACT [GOC:TermGenie]
synonym: "downregulation of hemolymph circulation" RELATED [GOC:TermGenie]
synonym: "inhibition of blood circulation" NARROW [GOC:TermGenie]
synonym: "inhibition of hemolymph circulation" RELATED [GOC:TermGenie]
synonym: "negative regulation of hemolymph circulation" RELATED [GOC:TermGenie]
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1903522 ! regulation of blood circulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008015 ! blood circulation
relationship: negatively_regulates GO:0008015 ! blood circulation
created_by: mr
creation_date: 2014-10-06T18:39:05Z

[Term]
id: GO:1903524
name: positive regulation of blood circulation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of blood circulation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10659969]
synonym: "activation of blood circulation" NARROW [GOC:TermGenie]
synonym: "activation of hemolymph circulation" RELATED [GOC:TermGenie]
synonym: "positive regulation of hemolymph circulation" RELATED [GOC:TermGenie]
synonym: "up regulation of blood circulation" EXACT [GOC:TermGenie]
synonym: "up regulation of hemolymph circulation" RELATED [GOC:TermGenie]
synonym: "up-regulation of blood circulation" EXACT [GOC:TermGenie]
synonym: "up-regulation of hemolymph circulation" RELATED [GOC:TermGenie]
synonym: "upregulation of blood circulation" EXACT [GOC:TermGenie]
synonym: "upregulation of hemolymph circulation" RELATED [GOC:TermGenie]
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1903522 ! regulation of blood circulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008015 ! blood circulation
relationship: positively_regulates GO:0008015 ! blood circulation
created_by: mr
creation_date: 2014-10-06T18:39:13Z

[Term]
id: GO:1903525
name: regulation of membrane tubulation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of membrane tubulation." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:18388313]
synonym: "regulation of plasma membrane tubulation" EXACT [GOC:TermGenie]
synonym: "regulation of vesicle scission" RELATED [GOC:TermGenie]
is_a: GO:1903729 ! regulation of plasma membrane organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097320 ! membrane tubulation
relationship: regulates GO:0097320 ! membrane tubulation
created_by: pm
creation_date: 2014-10-07T12:52:36Z

[Term]
id: GO:1903526
name: negative regulation of membrane tubulation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of membrane tubulation." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:18388313]
synonym: "down regulation of membrane tubulation" EXACT [GOC:TermGenie]
synonym: "down regulation of plasma membrane tubulation" EXACT [GOC:TermGenie]
synonym: "down-regulation of membrane tubulation" EXACT [GOC:TermGenie]
synonym: "down-regulation of plasma membrane tubulation" EXACT [GOC:TermGenie]
synonym: "downregulation of membrane tubulation" EXACT [GOC:TermGenie]
synonym: "downregulation of plasma membrane tubulation" EXACT [GOC:TermGenie]
synonym: "inhibition of membrane tubulation" NARROW [GOC:TermGenie]
synonym: "inhibition of plasma membrane tubulation" NARROW [GOC:TermGenie]
synonym: "negative regulation of plasma membrane tubulation" EXACT [GOC:TermGenie]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1903525 ! regulation of membrane tubulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097320 ! membrane tubulation
relationship: negatively_regulates GO:0097320 ! membrane tubulation
created_by: pm
creation_date: 2014-10-07T12:52:45Z

[Term]
id: GO:1903527
name: positive regulation of membrane tubulation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of membrane tubulation." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:18388313]
synonym: "activation of membrane tubulation" NARROW [GOC:TermGenie]
synonym: "activation of plasma membrane tubulation" NARROW [GOC:TermGenie]
synonym: "positive regulation of plasma membrane tubulation" EXACT [GOC:TermGenie]
synonym: "up regulation of membrane tubulation" EXACT [GOC:TermGenie]
synonym: "up regulation of plasma membrane tubulation" EXACT [GOC:TermGenie]
synonym: "up-regulation of membrane tubulation" EXACT [GOC:TermGenie]
synonym: "up-regulation of plasma membrane tubulation" EXACT [GOC:TermGenie]
synonym: "upregulation of membrane tubulation" EXACT [GOC:TermGenie]
synonym: "upregulation of plasma membrane tubulation" EXACT [GOC:TermGenie]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1903525 ! regulation of membrane tubulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097320 ! membrane tubulation
relationship: positively_regulates GO:0097320 ! membrane tubulation
created_by: pm
creation_date: 2014-10-07T12:52:53Z

[Term]
id: GO:1903528
name: regulation of dCDP biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dCDP biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:16317005]
synonym: "regulation of dCDP anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of dCDP biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of dCDP formation" EXACT [GOC:TermGenie]
synonym: "regulation of dCDP synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900397 ! regulation of pyrimidine nucleotide biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006240 ! dCDP biosynthetic process
relationship: regulates GO:0006240 ! dCDP biosynthetic process
created_by: al
creation_date: 2014-10-07T15:01:18Z

[Term]
id: GO:1903529
name: negative regulation of dCDP biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of dCDP biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:16317005]
synonym: "down regulation of dCDP anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of dCDP biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of dCDP biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of dCDP formation" EXACT [GOC:TermGenie]
synonym: "down regulation of dCDP synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of dCDP anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of dCDP biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of dCDP biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of dCDP formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of dCDP synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of dCDP anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of dCDP biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of dCDP biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of dCDP formation" EXACT [GOC:TermGenie]
synonym: "downregulation of dCDP synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of dCDP anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of dCDP biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of dCDP biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of dCDP formation" NARROW [GOC:TermGenie]
synonym: "inhibition of dCDP synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of dCDP anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of dCDP biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of dCDP formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of dCDP synthesis" EXACT [GOC:TermGenie]
is_a: GO:1900398 ! negative regulation of pyrimidine nucleotide biosynthetic process
is_a: GO:1903528 ! regulation of dCDP biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006240 ! dCDP biosynthetic process
relationship: negatively_regulates GO:0006240 ! dCDP biosynthetic process
created_by: al
creation_date: 2014-10-07T15:01:27Z

[Term]
id: GO:1903530
name: regulation of secretion by cell
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of secretion by cell." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:12130530]
synonym: "regulation of cellular secretion" EXACT [GOC:TermGenie]
is_a: GO:0051046 ! regulation of secretion
is_a: GO:0060341 ! regulation of cellular localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032940 ! secretion by cell
relationship: regulates GO:0032940 ! secretion by cell
created_by: pm
creation_date: 2014-10-08T13:24:59Z

[Term]
id: GO:1903531
name: negative regulation of secretion by cell
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of secretion by cell." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:12130530]
synonym: "down regulation of cellular secretion" EXACT [GOC:TermGenie]
synonym: "down regulation of secretion by cell" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of secretion by cell" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of secretion by cell" EXACT [GOC:TermGenie]
synonym: "inhibition of cellular secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of secretion by cell" NARROW [GOC:TermGenie]
synonym: "negative regulation of cellular secretion" EXACT [GOC:TermGenie]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051048 ! negative regulation of secretion
is_a: GO:1903530 ! regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032940 ! secretion by cell
relationship: negatively_regulates GO:0032940 ! secretion by cell
created_by: pm
creation_date: 2014-10-08T13:25:08Z

[Term]
id: GO:1903532
name: positive regulation of secretion by cell
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of secretion by cell." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:12130530]
synonym: "activation of cellular secretion" NARROW [GOC:TermGenie]
synonym: "activation of secretion by cell" NARROW [GOC:TermGenie]
synonym: "positive regulation of cellular secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of secretion by cell" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of secretion by cell" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of secretion by cell" EXACT [GOC:TermGenie]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051047 ! positive regulation of secretion
is_a: GO:1903530 ! regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032940 ! secretion by cell
relationship: positively_regulates GO:0032940 ! secretion by cell
created_by: pm
creation_date: 2014-10-08T13:25:17Z

[Term]
id: GO:1903533
name: regulation of protein targeting
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein targeting." [GO_REF:0000058, GOC:TermGenie]
synonym: "regulation of nascent polypeptide association" RELATED [GOC:TermGenie]
synonym: "regulation of protein sorting along secretory pathway" NARROW [GOC:TermGenie]
is_a: GO:0033157 ! regulation of intracellular protein transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006605 ! protein targeting
relationship: regulates GO:0006605 ! protein targeting
created_by: al
creation_date: 2014-10-08T14:49:03Z

[Term]
id: GO:1903534
name: regulation of lactose biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lactose biosynthetic process." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:12018418]
synonym: "regulation of lactose anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of lactose biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of lactose formation" EXACT [GOC:TermGenie]
synonym: "regulation of lactose synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0005989 ! lactose biosynthetic process
relationship: regulates GO:0005989 ! lactose biosynthetic process
created_by: mr
creation_date: 2014-10-08T16:26:05Z

[Term]
id: GO:1903535
name: negative regulation of lactose biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lactose biosynthetic process." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:12018418]
synonym: "down regulation of lactose anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of lactose biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of lactose biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of lactose formation" EXACT [GOC:TermGenie]
synonym: "down regulation of lactose synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of lactose anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of lactose biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of lactose biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of lactose formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of lactose synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of lactose anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of lactose biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of lactose biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of lactose formation" EXACT [GOC:TermGenie]
synonym: "downregulation of lactose synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of lactose anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of lactose biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of lactose biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of lactose formation" NARROW [GOC:TermGenie]
synonym: "inhibition of lactose synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of lactose anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of lactose biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of lactose formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of lactose synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:1903534 ! regulation of lactose biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0005989 ! lactose biosynthetic process
relationship: negatively_regulates GO:0005989 ! lactose biosynthetic process
created_by: mr
creation_date: 2014-10-08T16:26:14Z

[Term]
id: GO:1903536
name: positive regulation of lactose biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lactose biosynthetic process." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:12018418]
synonym: "activation of lactose anabolism" NARROW [GOC:TermGenie]
synonym: "activation of lactose biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of lactose biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of lactose formation" NARROW [GOC:TermGenie]
synonym: "activation of lactose synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of lactose anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of lactose biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of lactose formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of lactose synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of lactose anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of lactose biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of lactose biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of lactose formation" EXACT [GOC:TermGenie]
synonym: "up regulation of lactose synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of lactose anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of lactose biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of lactose biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of lactose formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of lactose synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of lactose anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of lactose biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of lactose biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of lactose formation" EXACT [GOC:TermGenie]
synonym: "upregulation of lactose synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:1903534 ! regulation of lactose biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0005989 ! lactose biosynthetic process
relationship: positively_regulates GO:0005989 ! lactose biosynthetic process
created_by: mr
creation_date: 2014-10-08T16:26:29Z

[Term]
id: GO:1903537
name: meiotic cell cycle process involved in oocyte maturation
namespace: biological_process
def: "Any meiotic cell cycle process that is involved in oocyte maturation." [GO_REF:0000060, GOC:jz, GOC:TermGenie, PMID:25212395]
synonym: "meiosis involved in oocyte maturation" BROAD []
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:1903046 ! meiotic cell cycle process
intersection_of: GO:1903046 ! meiotic cell cycle process
intersection_of: part_of GO:0001556 ! oocyte maturation
relationship: part_of GO:0001556 ! oocyte maturation
created_by: pr
creation_date: 2014-10-09T10:46:14Z

[Term]
id: GO:1903538
name: regulation of meiotic cell cycle process involved in oocyte maturation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation." [GO_REF:0000058, GOC:jz, GOC:TermGenie, PMID:25212395]
synonym: "regulation of meiosis involved in oocyte maturation" BROAD [GOC:TermGenie]
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0051445 ! regulation of meiotic cell cycle
is_a: GO:1900193 ! regulation of oocyte maturation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1903537 ! meiotic cell cycle process involved in oocyte maturation
relationship: regulates GO:1903537 ! meiotic cell cycle process involved in oocyte maturation
created_by: pr
creation_date: 2014-10-09T10:52:38Z

[Term]
id: GO:1903539
name: protein localization to postsynaptic membrane
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a postsynaptic membrane." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, pmid:9753322]
synonym: "protein localisation in postsynaptic membrane" EXACT [GOC:TermGenie]
synonym: "protein localisation to postsynaptic membrane" EXACT [GOC:TermGenie]
synonym: "protein localization in postsynaptic membrane" EXACT [GOC:TermGenie]
is_a: GO:0035418 ! protein localization to synapse
is_a: GO:0072659 ! protein localization to plasma membrane
created_by: kmv
creation_date: 2014-10-10T11:23:53Z

[Term]
id: GO:1903540
name: establishment of protein localization to postsynaptic membrane
namespace: biological_process
def: "The directed movement of a protein to a specific location in a postsynaptic membrane." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, pmid:9753322]
synonym: "establishment of protein localisation in postsynaptic membrane" EXACT [GOC:TermGenie]
synonym: "establishment of protein localisation to postsynaptic membrane" EXACT [GOC:TermGenie]
synonym: "establishment of protein localization in postsynaptic membrane" EXACT [GOC:TermGenie]
is_a: GO:0090002 ! establishment of protein localization to plasma membrane
relationship: part_of GO:1903539 ! protein localization to postsynaptic membrane
created_by: kmv
creation_date: 2014-10-10T11:24:03Z

[Term]
id: GO:1903541
name: regulation of exosomal secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of exosomal secretion." [GO_REF:0000058, GOC:TermGenie, PMID:24105262]
synonym: "regulation of exosomal protein secretion" NARROW [GOC:TermGenie]
synonym: "regulation of exosomal secretory pathway" EXACT [GOC:TermGenie]
synonym: "regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie]
synonym: "regulation of secretion of exosome" EXACT [GOC:TermGenie]
is_a: GO:0017157 ! regulation of exocytosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990182 ! exosomal secretion
relationship: regulates GO:1990182 ! exosomal secretion
created_by: pga
creation_date: 2014-10-14T11:38:52Z

[Term]
id: GO:1903542
name: negative regulation of exosomal secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of exosomal secretion." [GO_REF:0000058, GOC:TermGenie, PMID:24105262]
synonym: "down regulation of exosomal protein secretion" NARROW [GOC:TermGenie]
synonym: "down regulation of exosomal secretion" EXACT [GOC:TermGenie]
synonym: "down regulation of exosomal secretory pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie]
synonym: "down regulation of secretion of exosome" EXACT [GOC:TermGenie]
synonym: "down-regulation of exosomal protein secretion" NARROW [GOC:TermGenie]
synonym: "down-regulation of exosomal secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of exosomal secretory pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of secretion of exosome" EXACT [GOC:TermGenie]
synonym: "downregulation of exosomal protein secretion" NARROW [GOC:TermGenie]
synonym: "downregulation of exosomal secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of exosomal secretory pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of secretion of exosome" EXACT [GOC:TermGenie]
synonym: "inhibition of exosomal protein secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of exosomal secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of exosomal secretory pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of extracellular vesicular exosome secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of secretion of exosome" NARROW [GOC:TermGenie]
synonym: "negative regulation of exosomal protein secretion" NARROW [GOC:TermGenie]
synonym: "negative regulation of exosomal secretory pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie]
synonym: "negative regulation of secretion of exosome" EXACT [GOC:TermGenie]
is_a: GO:0045920 ! negative regulation of exocytosis
is_a: GO:1903541 ! regulation of exosomal secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990182 ! exosomal secretion
relationship: negatively_regulates GO:1990182 ! exosomal secretion
created_by: pga
creation_date: 2014-10-14T11:39:02Z

[Term]
id: GO:1903543
name: positive regulation of exosomal secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of exosomal secretion." [GO_REF:0000058, GOC:TermGenie, PMID:24105262]
synonym: "activation of exosomal protein secretion" NARROW [GOC:TermGenie]
synonym: "activation of exosomal secretion" NARROW [GOC:TermGenie]
synonym: "activation of exosomal secretory pathway" NARROW [GOC:TermGenie]
synonym: "activation of extracellular vesicular exosome secretion" NARROW [GOC:TermGenie]
synonym: "activation of secretion of exosome" NARROW [GOC:TermGenie]
synonym: "positive regulation of exosomal protein secretion" NARROW [GOC:TermGenie]
synonym: "positive regulation of exosomal secretory pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie]
synonym: "positive regulation of secretion of exosome" EXACT [GOC:TermGenie]
synonym: "up regulation of exosomal protein secretion" NARROW [GOC:TermGenie]
synonym: "up regulation of exosomal secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of exosomal secretory pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of secretion of exosome" EXACT [GOC:TermGenie]
synonym: "up-regulation of exosomal protein secretion" NARROW [GOC:TermGenie]
synonym: "up-regulation of exosomal secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of exosomal secretory pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of secretion of exosome" EXACT [GOC:TermGenie]
synonym: "upregulation of exosomal protein secretion" NARROW [GOC:TermGenie]
synonym: "upregulation of exosomal secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of exosomal secretory pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of secretion of exosome" EXACT [GOC:TermGenie]
is_a: GO:0045921 ! positive regulation of exocytosis
is_a: GO:1903541 ! regulation of exosomal secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990182 ! exosomal secretion
relationship: positively_regulates GO:1990182 ! exosomal secretion
created_by: pga
creation_date: 2014-10-14T11:39:10Z

[Term]
id: GO:1903544
name: response to butyrate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a butyrate stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:9734870]
is_a: GO:0070542 ! response to fatty acid
created_by: mr
creation_date: 2014-10-17T13:57:25Z

[Term]
id: GO:1903545
name: cellular response to butyrate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a butyrate stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:9734870]
is_a: GO:0071398 ! cellular response to fatty acid
is_a: GO:1903544 ! response to butyrate
created_by: mr
creation_date: 2014-10-17T13:57:35Z

[Term]
id: GO:1903546
name: protein localization to photoreceptor outer segment
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a photoreceptor outer segment." [GO_REF:0000087, GOC:TermGenie, PMID:11481257, PMID:21867699]
synonym: "protein localisation in photoreceptor outer segment" EXACT [GOC:TermGenie]
synonym: "protein localisation to photoreceptor outer segment" EXACT [GOC:TermGenie]
synonym: "protein localization in photoreceptor outer segment" EXACT [GOC:TermGenie]
is_a: GO:0097499 ! protein localization to nonmotile primary cilium
created_by: krc
creation_date: 2014-10-17T21:14:11Z

[Term]
id: GO:1903547
name: regulation of growth hormone activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of growth hormone activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:3068266]
synonym: "regulation of GH activity" EXACT [GOC:TermGenie]
synonym: "regulation of pituitary growth hormone activity" NARROW [GOC:TermGenie]
synonym: "regulation of placental growth hormone activity" NARROW [GOC:TermGenie]
is_a: GO:1900120 ! regulation of receptor binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070186 ! growth hormone activity
relationship: regulates GO:0070186 ! growth hormone activity
created_by: mr
creation_date: 2014-10-20T15:18:36Z

[Term]
id: GO:1903548
name: negative regulation of growth hormone activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of growth hormone activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:3068266]
synonym: "down regulation of GH activity" EXACT [GOC:TermGenie]
synonym: "down regulation of growth hormone activity" EXACT [GOC:TermGenie]
synonym: "down regulation of pituitary growth hormone activity" NARROW [GOC:TermGenie]
synonym: "down regulation of placental growth hormone activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of GH activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of growth hormone activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of pituitary growth hormone activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of placental growth hormone activity" NARROW [GOC:TermGenie]
synonym: "downregulation of GH activity" EXACT [GOC:TermGenie]
synonym: "downregulation of growth hormone activity" EXACT [GOC:TermGenie]
synonym: "downregulation of pituitary growth hormone activity" NARROW [GOC:TermGenie]
synonym: "downregulation of placental growth hormone activity" NARROW [GOC:TermGenie]
synonym: "inhibition of GH activity" NARROW [GOC:TermGenie]
synonym: "inhibition of growth hormone activity" NARROW [GOC:TermGenie]
synonym: "inhibition of pituitary growth hormone activity" NARROW [GOC:TermGenie]
synonym: "inhibition of placental growth hormone activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of GH activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of pituitary growth hormone activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of placental growth hormone activity" NARROW [GOC:TermGenie]
is_a: GO:1900121 ! negative regulation of receptor binding
is_a: GO:1903547 ! regulation of growth hormone activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070186 ! growth hormone activity
relationship: negatively_regulates GO:0070186 ! growth hormone activity
created_by: mr
creation_date: 2014-10-20T15:18:45Z

[Term]
id: GO:1903549
name: positive regulation of growth hormone activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of growth hormone activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:3068266]
synonym: "activation of GH activity" NARROW [GOC:TermGenie]
synonym: "activation of growth hormone activity" NARROW [GOC:TermGenie]
synonym: "activation of pituitary growth hormone activity" NARROW [GOC:TermGenie]
synonym: "activation of placental growth hormone activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of GH activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of pituitary growth hormone activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of placental growth hormone activity" NARROW [GOC:TermGenie]
synonym: "up regulation of GH activity" EXACT [GOC:TermGenie]
synonym: "up regulation of growth hormone activity" EXACT [GOC:TermGenie]
synonym: "up regulation of pituitary growth hormone activity" NARROW [GOC:TermGenie]
synonym: "up regulation of placental growth hormone activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of GH activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of growth hormone activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of pituitary growth hormone activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of placental growth hormone activity" NARROW [GOC:TermGenie]
synonym: "upregulation of GH activity" EXACT [GOC:TermGenie]
synonym: "upregulation of growth hormone activity" EXACT [GOC:TermGenie]
synonym: "upregulation of pituitary growth hormone activity" NARROW [GOC:TermGenie]
synonym: "upregulation of placental growth hormone activity" NARROW [GOC:TermGenie]
is_a: GO:1900122 ! positive regulation of receptor binding
is_a: GO:1903547 ! regulation of growth hormone activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070186 ! growth hormone activity
relationship: positively_regulates GO:0070186 ! growth hormone activity
created_by: mr
creation_date: 2014-10-20T15:18:53Z

[Term]
id: GO:1903551
name: regulation of extracellular exosome assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of extracellular vesicular exosome assembly." [GO_REF:0000058, GOC:TermGenie, PMID:24105262]
synonym: "regulation of extracellular vesicular exosome assembly" EXACT [GOC:vesicles]
is_a: GO:1902115 ! regulation of organelle assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071971 ! extracellular exosome assembly
relationship: regulates GO:0071971 ! extracellular exosome assembly
created_by: pga
creation_date: 2014-10-20T15:37:25Z

[Term]
id: GO:1903552
name: negative regulation of extracellular exosome assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of extracellular vesicular exosome assembly." [GO_REF:0000058, GOC:TermGenie, PMID:24105262]
synonym: "down regulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of extracellular vesicular exosome assembly" NARROW [GOC:TermGenie]
synonym: "negative regulation of extracellular vesicular exosome assembly" EXACT [GOC:vesicles]
is_a: GO:1902116 ! negative regulation of organelle assembly
is_a: GO:1903551 ! regulation of extracellular exosome assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071971 ! extracellular exosome assembly
relationship: negatively_regulates GO:0071971 ! extracellular exosome assembly
created_by: pga
creation_date: 2014-10-20T15:37:33Z

[Term]
id: GO:1903553
name: positive regulation of extracellular exosome assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of extracellular vesicular exosome assembly." [GO_REF:0000058, GOC:TermGenie, PMID:24105262]
synonym: "activation of extracellular vesicular exosome assembly" NARROW [GOC:TermGenie]
synonym: "positive regulation of extracellular vesicular exosome assembly" RELATED [GOC:vesicles]
synonym: "up regulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie]
is_a: GO:1902117 ! positive regulation of organelle assembly
is_a: GO:1903551 ! regulation of extracellular exosome assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071971 ! extracellular exosome assembly
relationship: positively_regulates GO:0071971 ! extracellular exosome assembly
created_by: pga
creation_date: 2014-10-20T15:37:42Z

[Term]
id: GO:1903554
name: G-protein coupled receptor signaling pathway involved in defense response to Gram-negative bacterium
namespace: biological_process
def: "Any G-protein coupled receptor signaling pathway that is involved in defense response to Gram-negative bacterium." [GO_REF:0000060, GOC:kmv, GOC:TermGenie, pmid:25303524]
synonym: "G protein coupled receptor protein signaling pathway involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "G protein coupled receptor protein signaling pathway involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "G protein coupled receptor protein signaling pathway involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "G protein coupled receptor protein signaling pathway involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "G protein coupled receptor protein signaling pathway involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "G protein coupled receptor protein signalling pathway involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "G protein coupled receptor protein signalling pathway involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "G protein coupled receptor protein signalling pathway involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "G protein coupled receptor protein signalling pathway involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "G protein coupled receptor protein signalling pathway involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "G-protein coupled receptor protein signal transduction involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "G-protein coupled receptor protein signal transduction involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "G-protein coupled receptor protein signal transduction involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "G-protein coupled receptor protein signal transduction involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "G-protein coupled receptor protein signal transduction involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "G-protein coupled receptor protein signaling pathway involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "G-protein coupled receptor protein signaling pathway involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "G-protein coupled receptor protein signaling pathway involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "G-protein coupled receptor protein signaling pathway involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "G-protein coupled receptor protein signaling pathway involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "G-protein coupled receptor signaling pathway involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "G-protein coupled receptor signaling pathway involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "G-protein coupled receptor signaling pathway involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "G-protein coupled receptor signaling pathway involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "G-protein coupled receptor signalling pathway involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "G-protein coupled receptor signalling pathway involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "G-protein coupled receptor signalling pathway involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "G-protein coupled receptor signalling pathway involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "G-protein coupled receptor signalling pathway involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "G-protein-coupled receptor protein signaling pathway involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "G-protein-coupled receptor protein signaling pathway involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "G-protein-coupled receptor protein signaling pathway involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "G-protein-coupled receptor protein signaling pathway involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "G-protein-coupled receptor protein signaling pathway involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "G-protein-coupled receptor protein signalling pathway involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "G-protein-coupled receptor protein signalling pathway involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "G-protein-coupled receptor protein signalling pathway involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "G-protein-coupled receptor protein signalling pathway involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "G-protein-coupled receptor protein signalling pathway involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "GPCR signaling pathway involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "GPCR signaling pathway involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "GPCR signaling pathway involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "GPCR signaling pathway involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "GPCR signaling pathway involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "GPCR signalling pathway involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "GPCR signalling pathway involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "GPCR signalling pathway involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie]
synonym: "GPCR signalling pathway involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie]
synonym: "GPCR signalling pathway involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie]
is_a: GO:0007186 ! G-protein coupled receptor signaling pathway
intersection_of: GO:0007186 ! G-protein coupled receptor signaling pathway
intersection_of: part_of GO:0050829 ! defense response to Gram-negative bacterium
relationship: part_of GO:0050829 ! defense response to Gram-negative bacterium
created_by: kmv
creation_date: 2014-10-20T17:51:13Z

[Term]
id: GO:1903555
name: regulation of tumor necrosis factor superfamily cytokine production
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tumor necrosis factor superfamily cytokine production." [GO_REF:0000058, GOC:TermGenie, PMID:24187568]
synonym: "regulation of TNF superfamily production" RELATED [GOC:TermGenie]
synonym: "regulation of TNFSF cytokine production" EXACT [GOC:TermGenie]
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071706 ! tumor necrosis factor superfamily cytokine production
relationship: regulates GO:0071706 ! tumor necrosis factor superfamily cytokine production
created_by: pga
creation_date: 2014-10-21T10:26:05Z

[Term]
id: GO:1903556
name: negative regulation of tumor necrosis factor superfamily cytokine production
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tumor necrosis factor superfamily cytokine production." [GO_REF:0000058, GOC:TermGenie, PMID:24187568]
synonym: "down regulation of TNF superfamily production" RELATED [GOC:TermGenie]
synonym: "down regulation of TNFSF cytokine production" EXACT [GOC:TermGenie]
synonym: "down regulation of tumor necrosis factor superfamily cytokine production" EXACT [GOC:TermGenie]
synonym: "down-regulation of TNF superfamily production" RELATED [GOC:TermGenie]
synonym: "down-regulation of TNFSF cytokine production" EXACT [GOC:TermGenie]
synonym: "down-regulation of tumor necrosis factor superfamily cytokine production" EXACT [GOC:TermGenie]
synonym: "downregulation of TNF superfamily production" RELATED [GOC:TermGenie]
synonym: "downregulation of TNFSF cytokine production" EXACT [GOC:TermGenie]
synonym: "downregulation of tumor necrosis factor superfamily cytokine production" EXACT [GOC:TermGenie]
synonym: "inhibition of TNF superfamily production" RELATED [GOC:TermGenie]
synonym: "inhibition of TNFSF cytokine production" NARROW [GOC:TermGenie]
synonym: "inhibition of tumor necrosis factor superfamily cytokine production" NARROW [GOC:TermGenie]
synonym: "negative regulation of TNF superfamily production" RELATED [GOC:TermGenie]
synonym: "negative regulation of TNFSF cytokine production" EXACT [GOC:TermGenie]
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:1903555 ! regulation of tumor necrosis factor superfamily cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071706 ! tumor necrosis factor superfamily cytokine production
relationship: negatively_regulates GO:0071706 ! tumor necrosis factor superfamily cytokine production
created_by: pga
creation_date: 2014-10-21T10:26:14Z

[Term]
id: GO:1903557
name: positive regulation of tumor necrosis factor superfamily cytokine production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tumor necrosis factor superfamily cytokine production." [GO_REF:0000058, GOC:TermGenie, PMID:24187568]
synonym: "activation of TNF superfamily production" RELATED [GOC:TermGenie]
synonym: "activation of TNFSF cytokine production" NARROW [GOC:TermGenie]
synonym: "activation of tumor necrosis factor superfamily cytokine production" NARROW [GOC:TermGenie]
synonym: "positive regulation of TNF superfamily production" RELATED [GOC:TermGenie]
synonym: "positive regulation of TNFSF cytokine production" EXACT [GOC:TermGenie]
synonym: "up regulation of TNF superfamily production" RELATED [GOC:TermGenie]
synonym: "up regulation of TNFSF cytokine production" EXACT [GOC:TermGenie]
synonym: "up regulation of tumor necrosis factor superfamily cytokine production" EXACT [GOC:TermGenie]
synonym: "up-regulation of TNF superfamily production" RELATED [GOC:TermGenie]
synonym: "up-regulation of TNFSF cytokine production" EXACT [GOC:TermGenie]
synonym: "up-regulation of tumor necrosis factor superfamily cytokine production" EXACT [GOC:TermGenie]
synonym: "upregulation of TNF superfamily production" RELATED [GOC:TermGenie]
synonym: "upregulation of TNFSF cytokine production" EXACT [GOC:TermGenie]
synonym: "upregulation of tumor necrosis factor superfamily cytokine production" EXACT [GOC:TermGenie]
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:1903555 ! regulation of tumor necrosis factor superfamily cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071706 ! tumor necrosis factor superfamily cytokine production
relationship: positively_regulates GO:0071706 ! tumor necrosis factor superfamily cytokine production
created_by: pga
creation_date: 2014-10-21T10:26:23Z

[Term]
id: GO:1903558
name: 3-cyano-L-alanine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 3-cyano-L-alanine." [GO_REF:0000068, GOC:kmv, GOC:TermGenie, pmid:24100226, pmid:24843024]
synonym: "3-cyano-L-alanine metabolism" EXACT [GOC:TermGenie]
is_a: GO:0033052 ! cyanoamino acid metabolic process
is_a: GO:1901605 ! alpha-amino acid metabolic process
created_by: kmv
creation_date: 2014-10-21T17:13:00Z

[Term]
id: GO:1903559
name: 3-cyano-L-alanine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 3-cyano-L-alanine." [GO_REF:0000068, GOC:kmv, GOC:TermGenie, pmid:24100226, pmid:24843024]
synonym: "3-cyano-L-alanine breakdown" EXACT [GOC:TermGenie]
synonym: "3-cyano-L-alanine catabolism" EXACT [GOC:TermGenie]
synonym: "3-cyano-L-alanine degradation" EXACT [GOC:TermGenie]
is_a: GO:0042219 ! cellular modified amino acid catabolic process
is_a: GO:0050899 ! nitrile catabolic process
is_a: GO:1901606 ! alpha-amino acid catabolic process
is_a: GO:1903558 ! 3-cyano-L-alanine metabolic process
created_by: kmv
creation_date: 2014-10-21T17:13:10Z

[Term]
id: GO:1903560
name: 3-cyano-L-alanine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 3-cyano-L-alanine." [GO_REF:0000068, GOC:kmv, GOC:TermGenie, pmid:24100226, pmid:24843024]
synonym: "3-cyano-L-alanine anabolism" EXACT [GOC:TermGenie]
synonym: "3-cyano-L-alanine biosynthesis" EXACT [GOC:TermGenie]
synonym: "3-cyano-L-alanine formation" EXACT [GOC:TermGenie]
synonym: "3-cyano-L-alanine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0042398 ! cellular modified amino acid biosynthetic process
is_a: GO:0080028 ! nitrile biosynthetic process
is_a: GO:1901607 ! alpha-amino acid biosynthetic process
is_a: GO:1903558 ! 3-cyano-L-alanine metabolic process
created_by: kmv
creation_date: 2014-10-21T17:13:26Z

[Term]
id: GO:1903561
name: extracellular vesicle
namespace: cellular_component
def: "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233]
synonym: "microparticle" RELATED [GOC:vesicles]
is_a: GO:0031982 ! vesicle
is_a: GO:0043230 ! extracellular organelle
intersection_of: GO:0031982 ! vesicle
intersection_of: part_of GO:0005576 ! extracellular region
relationship: part_of GO:0005576 ! extracellular region
created_by: jl
creation_date: 2014-10-22T14:26:11Z

[Term]
id: GO:1903562
name: microtubule bundle formation involved in mitotic spindle midzone assembly
namespace: biological_process
def: "Any microtubule bundle formation that is involved in spindle midzone assembly involved in mitosis." [GO_REF:0000060, GOC:TermGenie, PMID:15647375]
synonym: "microtubule bundle formation involved in mitotic spindle midzone assembly" EXACT [GOC:TermGenie]
synonym: "microtubule bundle formation involved in mitotic spindle midzone formation" EXACT [GOC:TermGenie]
synonym: "microtubule bundle formation involved in spindle midzone assembly involved in mitosis" EXACT [GOC:dos]
synonym: "microtubule bundling involved in mitotic spindle midzone assembly" RELATED [GOC:TermGenie]
synonym: "microtubule bundling involved in mitotic spindle midzone formation" EXACT [GOC:TermGenie]
synonym: "microtubule bundling involved in spindle midzone assembly involved in mitosis" EXACT [GOC:TermGenie]
synonym: "microtubule bundling involved in spindle midzone biogenesis involved in mitosis" EXACT [GOC:TermGenie]
synonym: "microtubule bundling involved in spindle midzone formation involved in mitosis" EXACT [GOC:TermGenie]
is_a: GO:0001578 ! microtubule bundle formation
is_a: GO:1902850 ! microtubule cytoskeleton organization involved in mitosis
intersection_of: GO:0001578 ! microtubule bundle formation
intersection_of: part_of GO:0051256 ! mitotic spindle midzone assembly
relationship: part_of GO:0051256 ! mitotic spindle midzone assembly
created_by: vw
creation_date: 2014-10-23T11:04:56Z

[Term]
id: GO:1903563
name: microtubule bundle formation involved in horsetail-astral microtubule organization
namespace: biological_process
def: "Any microtubule bundle formation that is involved in horsetail-astral microtubule organization." [GO_REF:0000060, GOC:TermGenie, PMID:15647375]
synonym: "microtubule bundle formation involved in horsetail-astral microtubule array organization" EXACT [GOC:TermGenie]
synonym: "microtubule bundle formation involved in horsetail-astral microtubule organisation" EXACT [GOC:TermGenie]
synonym: "microtubule bundling involved in horsetail-astral microtubule array organization" EXACT [GOC:TermGenie]
synonym: "microtubule bundling involved in horsetail-astral microtubule organisation" EXACT [GOC:TermGenie]
synonym: "microtubule bundling involved in horsetail-astral microtubule organization" EXACT [GOC:TermGenie]
is_a: GO:0001578 ! microtubule bundle formation
is_a: GO:1903046 ! meiotic cell cycle process
intersection_of: GO:0001578 ! microtubule bundle formation
intersection_of: part_of GO:0032118 ! horsetail-astral microtubule organization
relationship: part_of GO:0032118 ! horsetail-astral microtubule organization
created_by: vw
creation_date: 2014-10-23T11:06:35Z

[Term]
id: GO:1903564
name: regulation of protein localization to cilium
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to cilium." [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:22072986]
is_a: GO:1903827 ! regulation of cellular protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061512 ! protein localization to cilium
relationship: regulates GO:0061512 ! protein localization to cilium
created_by: krc
creation_date: 2014-10-24T20:58:11Z

[Term]
id: GO:1903565
name: negative regulation of protein localization to cilium
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cilium." [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:22072986]
synonym: "down regulation of protein localization to cilium" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to cilium" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to cilium" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localization to cilium" NARROW [GOC:TermGenie]
is_a: GO:1903564 ! regulation of protein localization to cilium
is_a: GO:1903828 ! negative regulation of cellular protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061512 ! protein localization to cilium
relationship: negatively_regulates GO:0061512 ! protein localization to cilium
created_by: krc
creation_date: 2014-10-24T20:58:20Z

[Term]
id: GO:1903566
name: positive regulation of protein localization to cilium
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to cilium." [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:22072986]
synonym: "activation of protein localization to cilium" NARROW [GOC:TermGenie]
synonym: "up regulation of protein localization to cilium" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to cilium" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to cilium" EXACT [GOC:TermGenie]
is_a: GO:1903564 ! regulation of protein localization to cilium
is_a: GO:1903829 ! positive regulation of cellular protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061512 ! protein localization to cilium
relationship: positively_regulates GO:0061512 ! protein localization to cilium
created_by: krc
creation_date: 2014-10-24T20:58:28Z

[Term]
id: GO:1903567
name: regulation of protein localization to ciliary membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to ciliary membrane." [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:22072986]
synonym: "regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie]
is_a: GO:1903076 ! regulation of protein localization to plasma membrane
is_a: GO:1903564 ! regulation of protein localization to cilium
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1903441 ! protein localization to ciliary membrane
relationship: regulates GO:1903441 ! protein localization to ciliary membrane
created_by: krc
creation_date: 2014-10-24T21:32:51Z

[Term]
id: GO:1903568
name: negative regulation of protein localization to ciliary membrane
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to ciliary membrane." [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:22072986]
synonym: "down regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localisation in ciliary membrane" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localisation to ciliary membrane" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization in ciliary membrane" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to ciliary membrane" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie]
is_a: GO:1903077 ! negative regulation of protein localization to plasma membrane
is_a: GO:1903565 ! negative regulation of protein localization to cilium
is_a: GO:1903567 ! regulation of protein localization to ciliary membrane
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1903441 ! protein localization to ciliary membrane
relationship: negatively_regulates GO:1903441 ! protein localization to ciliary membrane
created_by: krc
creation_date: 2014-10-24T21:32:59Z

[Term]
id: GO:1903569
name: positive regulation of protein localization to ciliary membrane
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to ciliary membrane." [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:22072986]
synonym: "activation of protein localisation in ciliary membrane" NARROW [GOC:TermGenie]
synonym: "activation of protein localisation to ciliary membrane" NARROW [GOC:TermGenie]
synonym: "activation of protein localization in ciliary membrane" NARROW [GOC:TermGenie]
synonym: "activation of protein localization to ciliary membrane" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie]
is_a: GO:1903078 ! positive regulation of protein localization to plasma membrane
is_a: GO:1903566 ! positive regulation of protein localization to cilium
is_a: GO:1903567 ! regulation of protein localization to ciliary membrane
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1903441 ! protein localization to ciliary membrane
relationship: positively_regulates GO:1903441 ! protein localization to ciliary membrane
created_by: krc
creation_date: 2014-10-24T21:33:08Z

[Term]
id: GO:1903570
name: regulation of protein kinase D signaling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein kinase D signaling." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20497126]
synonym: "regulation of PKD signal transduction" EXACT [GOC:TermGenie]
synonym: "regulation of PKD signaling cascade" RELATED [GOC:TermGenie]
synonym: "regulation of protein kinase D signal transduction" EXACT [GOC:TermGenie]
synonym: "regulation of protein kinase D signaling cascade" RELATED [GOC:TermGenie]
synonym: "regulation of protein kinase D signalling cascade" RELATED [GOC:TermGenie]
is_a: GO:1902531 ! regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0089700 ! protein kinase D signaling
relationship: regulates GO:0089700 ! protein kinase D signaling
created_by: rl
creation_date: 2014-10-27T15:18:00Z

[Term]
id: GO:1903571
name: negative regulation of protein kinase D signaling
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein kinase D signaling." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20497126]
synonym: "down regulation of PKD signal transduction" EXACT [GOC:TermGenie]
synonym: "down regulation of PKD signaling cascade" RELATED [GOC:TermGenie]
synonym: "down regulation of protein kinase D signal transduction" EXACT [GOC:TermGenie]
synonym: "down regulation of protein kinase D signaling" EXACT [GOC:TermGenie]
synonym: "down regulation of protein kinase D signaling cascade" RELATED [GOC:TermGenie]
synonym: "down regulation of protein kinase D signalling cascade" RELATED [GOC:TermGenie]
synonym: "down-regulation of PKD signal transduction" EXACT [GOC:TermGenie]
synonym: "down-regulation of PKD signaling cascade" RELATED [GOC:TermGenie]
synonym: "down-regulation of protein kinase D signal transduction" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein kinase D signaling" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein kinase D signaling cascade" RELATED [GOC:TermGenie]
synonym: "down-regulation of protein kinase D signalling cascade" RELATED [GOC:TermGenie]
synonym: "downregulation of PKD signal transduction" EXACT [GOC:TermGenie]
synonym: "downregulation of PKD signaling cascade" RELATED [GOC:TermGenie]
synonym: "downregulation of protein kinase D signal transduction" EXACT [GOC:TermGenie]
synonym: "downregulation of protein kinase D signaling" EXACT [GOC:TermGenie]
synonym: "downregulation of protein kinase D signaling cascade" RELATED [GOC:TermGenie]
synonym: "downregulation of protein kinase D signalling cascade" RELATED [GOC:TermGenie]
synonym: "inhibition of PKD signal transduction" NARROW [GOC:TermGenie]
synonym: "inhibition of PKD signaling cascade" RELATED [GOC:TermGenie]
synonym: "inhibition of protein kinase D signal transduction" NARROW [GOC:TermGenie]
synonym: "inhibition of protein kinase D signaling" NARROW [GOC:TermGenie]
synonym: "inhibition of protein kinase D signaling cascade" RELATED [GOC:TermGenie]
synonym: "inhibition of protein kinase D signalling cascade" RELATED [GOC:TermGenie]
synonym: "negative regulation of PKD signal transduction" EXACT [GOC:TermGenie]
synonym: "negative regulation of PKD signaling cascade" RELATED [GOC:TermGenie]
synonym: "negative regulation of protein kinase D signal transduction" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein kinase D signaling cascade" RELATED [GOC:TermGenie]
synonym: "negative regulation of protein kinase D signalling cascade" RELATED [GOC:TermGenie]
is_a: GO:1902532 ! negative regulation of intracellular signal transduction
is_a: GO:1903570 ! regulation of protein kinase D signaling
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0089700 ! protein kinase D signaling
relationship: negatively_regulates GO:0089700 ! protein kinase D signaling
created_by: rl
creation_date: 2014-10-27T15:18:10Z

[Term]
id: GO:1903572
name: positive regulation of protein kinase D signaling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein kinase D signaling." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20497126]
synonym: "activation of PKD signal transduction" NARROW [GOC:TermGenie]
synonym: "activation of PKD signaling cascade" RELATED [GOC:TermGenie]
synonym: "activation of protein kinase D signal transduction" NARROW [GOC:TermGenie]
synonym: "activation of protein kinase D signaling" NARROW [GOC:TermGenie]
synonym: "activation of protein kinase D signaling cascade" RELATED [GOC:TermGenie]
synonym: "activation of protein kinase D signalling cascade" RELATED [GOC:TermGenie]
synonym: "positive regulation of PKD signal transduction" EXACT [GOC:TermGenie]
synonym: "positive regulation of PKD signaling cascade" RELATED [GOC:TermGenie]
synonym: "positive regulation of protein kinase D signal transduction" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein kinase D signaling cascade" RELATED [GOC:TermGenie]
synonym: "positive regulation of protein kinase D signalling cascade" RELATED [GOC:TermGenie]
synonym: "up regulation of PKD signal transduction" EXACT [GOC:TermGenie]
synonym: "up regulation of PKD signaling cascade" RELATED [GOC:TermGenie]
synonym: "up regulation of protein kinase D signal transduction" EXACT [GOC:TermGenie]
synonym: "up regulation of protein kinase D signaling" EXACT [GOC:TermGenie]
synonym: "up regulation of protein kinase D signaling cascade" RELATED [GOC:TermGenie]
synonym: "up regulation of protein kinase D signalling cascade" RELATED [GOC:TermGenie]
synonym: "up-regulation of PKD signal transduction" EXACT [GOC:TermGenie]
synonym: "up-regulation of PKD signaling cascade" RELATED [GOC:TermGenie]
synonym: "up-regulation of protein kinase D signal transduction" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein kinase D signaling" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein kinase D signaling cascade" RELATED [GOC:TermGenie]
synonym: "up-regulation of protein kinase D signalling cascade" RELATED [GOC:TermGenie]
synonym: "upregulation of PKD signal transduction" EXACT [GOC:TermGenie]
synonym: "upregulation of PKD signaling cascade" RELATED [GOC:TermGenie]
synonym: "upregulation of protein kinase D signal transduction" EXACT [GOC:TermGenie]
synonym: "upregulation of protein kinase D signaling" EXACT [GOC:TermGenie]
synonym: "upregulation of protein kinase D signaling cascade" RELATED [GOC:TermGenie]
synonym: "upregulation of protein kinase D signalling cascade" RELATED [GOC:TermGenie]
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
is_a: GO:1903570 ! regulation of protein kinase D signaling
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0089700 ! protein kinase D signaling
relationship: positively_regulates GO:0089700 ! protein kinase D signaling
created_by: rl
creation_date: 2014-10-27T15:18:18Z

[Term]
id: GO:1903573
name: negative regulation of response to endoplasmic reticulum stress
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of a response to endoplasmic reticulum stress." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11381086]
synonym: "down regulation of cellular response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "down regulation of ER stress response" EXACT [GOC:TermGenie]
synonym: "down regulation of response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "down regulation of response to ER stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of ER stress response" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to ER stress" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "downregulation of ER stress response" EXACT [GOC:TermGenie]
synonym: "downregulation of response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "downregulation of response to ER stress" EXACT [GOC:TermGenie]
synonym: "inhibition of cellular response to endoplasmic reticulum stress" NARROW [GOC:TermGenie]
synonym: "inhibition of ER stress response" NARROW [GOC:TermGenie]
synonym: "inhibition of response to endoplasmic reticulum stress" NARROW [GOC:TermGenie]
synonym: "inhibition of response to ER stress" NARROW [GOC:TermGenie]
synonym: "negative regulation of cellular response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "negative regulation of ER stress response" EXACT [GOC:TermGenie]
synonym: "negative regulation of response to ER stress" EXACT [GOC:TermGenie]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:0080135 ! regulation of cellular response to stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034976 ! response to endoplasmic reticulum stress
relationship: negatively_regulates GO:0034976 ! response to endoplasmic reticulum stress
created_by: bf
creation_date: 2014-10-27T16:15:30Z

[Term]
id: GO:1903574
name: negative regulation of cellular response to amino acid starvation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of a cellular response to amino acid starvation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11381086]
synonym: "down regulation of cellular response to amino acid starvation" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular response to amino acid starvation" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular response to amino acid starvation" EXACT [GOC:TermGenie]
synonym: "inhibition of cellular response to amino acid starvation" NARROW [GOC:TermGenie]
is_a: GO:0010648 ! negative regulation of cell communication
is_a: GO:0032108 ! negative regulation of response to nutrient levels
is_a: GO:1903832 ! regulation of cellular response to amino acid starvation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034198 ! cellular response to amino acid starvation
relationship: negatively_regulates GO:0034198 ! cellular response to amino acid starvation
created_by: bf
creation_date: 2014-10-27T16:21:02Z

[Term]
id: GO:1903575
name: cornified envelope assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a cornified envelope." [GO_REF:0000079, GOC:pm, GOC:TermGenie, PMID:22226963, PMID:24794495]
comment: An example of this is syntaxin 4 in PMID:22226963.
synonym: "cornified envelope formation" EXACT [GOC:TermGenie]
is_a: GO:0007009 ! plasma membrane organization
is_a: GO:0071709 ! membrane assembly
relationship: has_part GO:0003810 ! protein-glutamine gamma-glutamyltransferase activity
created_by: pr
creation_date: 2014-10-28T10:22:49Z

[Term]
id: GO:1903576
name: response to L-arginine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-arginine stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:6394628]
is_a: GO:0043200 ! response to amino acid
created_by: mr
creation_date: 2014-10-29T22:18:39Z

[Term]
id: GO:1903577
name: cellular response to L-arginine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-arginine stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:6394628]
is_a: GO:0071230 ! cellular response to amino acid stimulus
is_a: GO:1903576 ! response to L-arginine
created_by: mr
creation_date: 2014-10-29T22:18:54Z

[Term]
id: GO:1903578
name: regulation of ATP metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ATP metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:20695849]
synonym: "regulation of ATP metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009118 ! regulation of nucleoside metabolic process
is_a: GO:1900542 ! regulation of purine nucleotide metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0046034 ! ATP metabolic process
relationship: regulates GO:0046034 ! ATP metabolic process
created_by: sl
creation_date: 2014-10-30T19:04:24Z

[Term]
id: GO:1903579
name: negative regulation of ATP metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ATP metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:20695849]
synonym: "down regulation of ATP metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of ATP metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of ATP metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of ATP metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of ATP metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of ATP metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of ATP metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of ATP metabolism" NARROW [GOC:TermGenie]
synonym: "negative regulation of ATP metabolism" EXACT [GOC:TermGenie]
is_a: GO:0045978 ! negative regulation of nucleoside metabolic process
is_a: GO:1900543 ! negative regulation of purine nucleotide metabolic process
is_a: GO:1903578 ! regulation of ATP metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0046034 ! ATP metabolic process
relationship: negatively_regulates GO:0046034 ! ATP metabolic process
created_by: sl
creation_date: 2014-10-30T19:04:33Z

[Term]
id: GO:1903580
name: positive regulation of ATP metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ATP metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:20695849]
synonym: "activation of ATP metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of ATP metabolism" NARROW [GOC:TermGenie]
synonym: "positive regulation of ATP metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of ATP metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of ATP metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of ATP metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of ATP metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of ATP metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of ATP metabolism" EXACT [GOC:TermGenie]
is_a: GO:0045979 ! positive regulation of nucleoside metabolic process
is_a: GO:1900544 ! positive regulation of purine nucleotide metabolic process
is_a: GO:1903578 ! regulation of ATP metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0046034 ! ATP metabolic process
relationship: positively_regulates GO:0046034 ! ATP metabolic process
created_by: sl
creation_date: 2014-10-30T19:04:42Z

[Term]
id: GO:1903581
name: regulation of basophil degranulation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of basophil degranulation." [GO_REF:0000058, GOC:TermGenie, PMID:10880837]
is_a: GO:0002694 ! regulation of leukocyte activation
is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity
is_a: GO:0043300 ! regulation of leukocyte degranulation
is_a: GO:0050776 ! regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002561 ! basophil degranulation
relationship: regulates GO:0002561 ! basophil degranulation
created_by: sl
creation_date: 2014-10-31T17:37:24Z

[Term]
id: GO:1903582
name: negative regulation of basophil degranulation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of basophil degranulation." [GO_REF:0000058, GOC:TermGenie, PMID:10880837]
synonym: "down regulation of basophil degranulation" EXACT [GOC:TermGenie]
synonym: "down-regulation of basophil degranulation" EXACT [GOC:TermGenie]
synonym: "downregulation of basophil degranulation" EXACT [GOC:TermGenie]
synonym: "inhibition of basophil degranulation" NARROW [GOC:TermGenie]
is_a: GO:0002695 ! negative regulation of leukocyte activation
is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity
is_a: GO:0043301 ! negative regulation of leukocyte degranulation
is_a: GO:0050777 ! negative regulation of immune response
is_a: GO:1903581 ! regulation of basophil degranulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002561 ! basophil degranulation
relationship: negatively_regulates GO:0002561 ! basophil degranulation
created_by: sl
creation_date: 2014-10-31T17:37:33Z

[Term]
id: GO:1903583
name: positive regulation of basophil degranulation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of basophil degranulation." [GO_REF:0000058, GOC:TermGenie, PMID:10880837]
synonym: "activation of basophil degranulation" NARROW [GOC:TermGenie]
synonym: "up regulation of basophil degranulation" EXACT [GOC:TermGenie]
synonym: "up-regulation of basophil degranulation" EXACT [GOC:TermGenie]
synonym: "upregulation of basophil degranulation" EXACT [GOC:TermGenie]
is_a: GO:0002696 ! positive regulation of leukocyte activation
is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity
is_a: GO:0043302 ! positive regulation of leukocyte degranulation
is_a: GO:0050778 ! positive regulation of immune response
is_a: GO:1903581 ! regulation of basophil degranulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002561 ! basophil degranulation
relationship: positively_regulates GO:0002561 ! basophil degranulation
created_by: sl
creation_date: 2014-10-31T17:37:42Z

[Term]
id: GO:1903584
name: regulation of histone deubiquitination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of histone deubiquitination." [GO_REF:0000058, GOC:TermGenie, Pubmed:24526689]
synonym: "regulation of histone deubiquitinylation" EXACT [GOC:TermGenie]
synonym: "regulation of histone deubiquitylation" EXACT [GOC:TermGenie]
is_a: GO:0031056 ! regulation of histone modification
is_a: GO:0090085 ! regulation of protein deubiquitination
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016578 ! histone deubiquitination
relationship: regulates GO:0016578 ! histone deubiquitination
created_by: lb
creation_date: 2014-11-03T13:47:26Z

[Term]
id: GO:1903585
name: negative regulation of histone deubiquitination
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone deubiquitination." [GO_REF:0000058, GOC:TermGenie, Pubmed:24526689]
synonym: "down regulation of histone deubiquitination" EXACT [GOC:TermGenie]
synonym: "down regulation of histone deubiquitinylation" EXACT [GOC:TermGenie]
synonym: "down regulation of histone deubiquitylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of histone deubiquitination" EXACT [GOC:TermGenie]
synonym: "down-regulation of histone deubiquitinylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of histone deubiquitylation" EXACT [GOC:TermGenie]
synonym: "downregulation of histone deubiquitination" EXACT [GOC:TermGenie]
synonym: "downregulation of histone deubiquitinylation" EXACT [GOC:TermGenie]
synonym: "downregulation of histone deubiquitylation" EXACT [GOC:TermGenie]
synonym: "inhibition of histone deubiquitination" NARROW [GOC:TermGenie]
synonym: "inhibition of histone deubiquitinylation" NARROW [GOC:TermGenie]
synonym: "inhibition of histone deubiquitylation" NARROW [GOC:TermGenie]
synonym: "negative regulation of histone deubiquitinylation" EXACT [GOC:TermGenie]
synonym: "negative regulation of histone deubiquitylation" EXACT [GOC:TermGenie]
is_a: GO:0031057 ! negative regulation of histone modification
is_a: GO:0090086 ! negative regulation of protein deubiquitination
is_a: GO:1903584 ! regulation of histone deubiquitination
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016578 ! histone deubiquitination
relationship: negatively_regulates GO:0016578 ! histone deubiquitination
created_by: lb
creation_date: 2014-11-03T13:47:35Z

[Term]
id: GO:1903586
name: positive regulation of histone deubiquitination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of histone deubiquitination." [GO_REF:0000058, GOC:TermGenie, Pubmed:24526689]
synonym: "activation of histone deubiquitination" NARROW [GOC:TermGenie]
synonym: "activation of histone deubiquitinylation" NARROW [GOC:TermGenie]
synonym: "activation of histone deubiquitylation" NARROW [GOC:TermGenie]
synonym: "positive regulation of histone deubiquitinylation" EXACT [GOC:TermGenie]
synonym: "positive regulation of histone deubiquitylation" EXACT [GOC:TermGenie]
synonym: "up regulation of histone deubiquitination" EXACT [GOC:TermGenie]
synonym: "up regulation of histone deubiquitinylation" EXACT [GOC:TermGenie]
synonym: "up regulation of histone deubiquitylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of histone deubiquitination" EXACT [GOC:TermGenie]
synonym: "up-regulation of histone deubiquitinylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of histone deubiquitylation" EXACT [GOC:TermGenie]
synonym: "upregulation of histone deubiquitination" EXACT [GOC:TermGenie]
synonym: "upregulation of histone deubiquitinylation" EXACT [GOC:TermGenie]
synonym: "upregulation of histone deubiquitylation" EXACT [GOC:TermGenie]
is_a: GO:0031058 ! positive regulation of histone modification
is_a: GO:1903003 ! positive regulation of protein deubiquitination
is_a: GO:1903584 ! regulation of histone deubiquitination
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016578 ! histone deubiquitination
relationship: positively_regulates GO:0016578 ! histone deubiquitination
created_by: lb
creation_date: 2014-11-03T13:47:44Z

[Term]
id: GO:1903587
name: regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of blood vessel endothelial cell proliferation involved in sprouting angiogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:23388056]
synonym: "regulation of blood vessel endothelial cell proliferation during sprouting angiogenesis" RELATED [GOC:TermGenie]
is_a: GO:0001936 ! regulation of endothelial cell proliferation
is_a: GO:1903670 ! regulation of sprouting angiogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002043 ! blood vessel endothelial cell proliferation involved in sprouting angiogenesis
relationship: regulates GO:0002043 ! blood vessel endothelial cell proliferation involved in sprouting angiogenesis
created_by: pga
creation_date: 2014-11-04T11:39:31Z

[Term]
id: GO:1903588
name: negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of blood vessel endothelial cell proliferation involved in sprouting angiogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:23388056]
synonym: "down regulation of blood vessel endothelial cell proliferation during sprouting angiogenesis" RELATED [GOC:TermGenie]
synonym: "down regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of blood vessel endothelial cell proliferation during sprouting angiogenesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of blood vessel endothelial cell proliferation during sprouting angiogenesis" RELATED [GOC:TermGenie]
synonym: "downregulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of blood vessel endothelial cell proliferation during sprouting angiogenesis" RELATED [GOC:TermGenie]
synonym: "inhibition of blood vessel endothelial cell proliferation involved in sprouting angiogenesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of blood vessel endothelial cell proliferation during sprouting angiogenesis" RELATED [GOC:TermGenie]
is_a: GO:0001937 ! negative regulation of endothelial cell proliferation
is_a: GO:1903587 ! regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
is_a: GO:1903671 ! negative regulation of sprouting angiogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002043 ! blood vessel endothelial cell proliferation involved in sprouting angiogenesis
relationship: negatively_regulates GO:0002043 ! blood vessel endothelial cell proliferation involved in sprouting angiogenesis
created_by: pga
creation_date: 2014-11-04T11:39:39Z

[Term]
id: GO:1903589
name: positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of blood vessel endothelial cell proliferation involved in sprouting angiogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:23388056]
synonym: "activation of blood vessel endothelial cell proliferation during sprouting angiogenesis" RELATED [GOC:TermGenie]
synonym: "activation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of blood vessel endothelial cell proliferation during sprouting angiogenesis" RELATED [GOC:TermGenie]
synonym: "up regulation of blood vessel endothelial cell proliferation during sprouting angiogenesis" RELATED [GOC:TermGenie]
synonym: "up regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of blood vessel endothelial cell proliferation during sprouting angiogenesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of blood vessel endothelial cell proliferation during sprouting angiogenesis" RELATED [GOC:TermGenie]
synonym: "upregulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis" EXACT [GOC:TermGenie]
is_a: GO:0001938 ! positive regulation of endothelial cell proliferation
is_a: GO:1903587 ! regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
is_a: GO:1903672 ! positive regulation of sprouting angiogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002043 ! blood vessel endothelial cell proliferation involved in sprouting angiogenesis
relationship: positively_regulates GO:0002043 ! blood vessel endothelial cell proliferation involved in sprouting angiogenesis
created_by: pga
creation_date: 2014-11-04T11:39:47Z

[Term]
id: GO:1903590
name: regulation of lysozyme activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lysozyme activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:23954697]
synonym: "regulation of 1,4-N-acetylmuramidase activity" EXACT [GOC:TermGenie]
synonym: "regulation of globulin G" RELATED [GOC:TermGenie]
synonym: "regulation of globulin G1" RELATED [GOC:TermGenie]
synonym: "regulation of L-7001" RELATED [GOC:TermGenie]
synonym: "regulation of lysozyme g" RELATED [GOC:TermGenie]
synonym: "regulation of mucopeptide glucohydrolase activity" EXACT [GOC:TermGenie]
synonym: "regulation of mucopeptide N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "regulation of muramidase activity" EXACT [GOC:TermGenie]
synonym: "regulation of N,O-diacetylmuramidase activity" EXACT [GOC:TermGenie]
synonym: "regulation of peptidoglycan N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "regulation of PR1-lysozyme" RELATED [GOC:TermGenie]
is_a: GO:0051336 ! regulation of hydrolase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003796 ! lysozyme activity
relationship: regulates GO:0003796 ! lysozyme activity
created_by: mr
creation_date: 2014-11-05T21:41:22Z

[Term]
id: GO:1903591
name: negative regulation of lysozyme activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lysozyme activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:23954697]
synonym: "down regulation of 1,4-N-acetylmuramidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of globulin G" RELATED [GOC:TermGenie]
synonym: "down regulation of globulin G1" RELATED [GOC:TermGenie]
synonym: "down regulation of L-7001" RELATED [GOC:TermGenie]
synonym: "down regulation of lysozyme activity" EXACT [GOC:TermGenie]
synonym: "down regulation of lysozyme g" RELATED [GOC:TermGenie]
synonym: "down regulation of mucopeptide glucohydrolase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of mucopeptide N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of muramidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of N,O-diacetylmuramidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of peptidoglycan N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of PR1-lysozyme" RELATED [GOC:TermGenie]
synonym: "down-regulation of 1,4-N-acetylmuramidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of globulin G" RELATED [GOC:TermGenie]
synonym: "down-regulation of globulin G1" RELATED [GOC:TermGenie]
synonym: "down-regulation of L-7001" RELATED [GOC:TermGenie]
synonym: "down-regulation of lysozyme activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of lysozyme g" RELATED [GOC:TermGenie]
synonym: "down-regulation of mucopeptide glucohydrolase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of mucopeptide N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of muramidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of N,O-diacetylmuramidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of peptidoglycan N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of PR1-lysozyme" RELATED [GOC:TermGenie]
synonym: "downregulation of 1,4-N-acetylmuramidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of globulin G" RELATED [GOC:TermGenie]
synonym: "downregulation of globulin G1" RELATED [GOC:TermGenie]
synonym: "downregulation of L-7001" RELATED [GOC:TermGenie]
synonym: "downregulation of lysozyme activity" EXACT [GOC:TermGenie]
synonym: "downregulation of lysozyme g" RELATED [GOC:TermGenie]
synonym: "downregulation of mucopeptide glucohydrolase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of mucopeptide N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of muramidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of N,O-diacetylmuramidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of peptidoglycan N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of PR1-lysozyme" RELATED [GOC:TermGenie]
synonym: "inhibition of 1,4-N-acetylmuramidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of globulin G" RELATED [GOC:TermGenie]
synonym: "inhibition of globulin G1" RELATED [GOC:TermGenie]
synonym: "inhibition of L-7001" RELATED [GOC:TermGenie]
synonym: "inhibition of lysozyme activity" NARROW [GOC:TermGenie]
synonym: "inhibition of lysozyme g" RELATED [GOC:TermGenie]
synonym: "inhibition of mucopeptide glucohydrolase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of mucopeptide N-acetylmuramoylhydrolase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of muramidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of N,O-diacetylmuramidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of peptidoglycan N-acetylmuramoylhydrolase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of PR1-lysozyme" RELATED [GOC:TermGenie]
synonym: "negative regulation of 1,4-N-acetylmuramidase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of globulin G" RELATED [GOC:TermGenie]
synonym: "negative regulation of globulin G1" RELATED [GOC:TermGenie]
synonym: "negative regulation of L-7001" RELATED [GOC:TermGenie]
synonym: "negative regulation of lysozyme g" RELATED [GOC:TermGenie]
synonym: "negative regulation of mucopeptide glucohydrolase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of mucopeptide N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of muramidase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of N,O-diacetylmuramidase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of peptidoglycan N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of PR1-lysozyme" RELATED [GOC:TermGenie]
is_a: GO:0051346 ! negative regulation of hydrolase activity
is_a: GO:1903590 ! regulation of lysozyme activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003796 ! lysozyme activity
relationship: negatively_regulates GO:0003796 ! lysozyme activity
created_by: mr
creation_date: 2014-11-05T21:41:30Z

[Term]
id: GO:1903592
name: positive regulation of lysozyme activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lysozyme activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:23954697]
synonym: "activation of 1,4-N-acetylmuramidase activity" NARROW [GOC:TermGenie]
synonym: "activation of globulin G" RELATED [GOC:TermGenie]
synonym: "activation of globulin G1" RELATED [GOC:TermGenie]
synonym: "activation of L-7001" RELATED [GOC:TermGenie]
synonym: "activation of lysozyme activity" NARROW [GOC:TermGenie]
synonym: "activation of lysozyme g" RELATED [GOC:TermGenie]
synonym: "activation of mucopeptide glucohydrolase activity" NARROW [GOC:TermGenie]
synonym: "activation of mucopeptide N-acetylmuramoylhydrolase activity" NARROW [GOC:TermGenie]
synonym: "activation of muramidase activity" NARROW [GOC:TermGenie]
synonym: "activation of N,O-diacetylmuramidase activity" NARROW [GOC:TermGenie]
synonym: "activation of peptidoglycan N-acetylmuramoylhydrolase activity" NARROW [GOC:TermGenie]
synonym: "activation of PR1-lysozyme" RELATED [GOC:TermGenie]
synonym: "positive regulation of 1,4-N-acetylmuramidase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of globulin G" RELATED [GOC:TermGenie]
synonym: "positive regulation of globulin G1" RELATED [GOC:TermGenie]
synonym: "positive regulation of L-7001" RELATED [GOC:TermGenie]
synonym: "positive regulation of lysozyme g" RELATED [GOC:TermGenie]
synonym: "positive regulation of mucopeptide glucohydrolase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of mucopeptide N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of muramidase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of N,O-diacetylmuramidase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of peptidoglycan N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of PR1-lysozyme" RELATED [GOC:TermGenie]
synonym: "up regulation of 1,4-N-acetylmuramidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of globulin G" RELATED [GOC:TermGenie]
synonym: "up regulation of globulin G1" RELATED [GOC:TermGenie]
synonym: "up regulation of L-7001" RELATED [GOC:TermGenie]
synonym: "up regulation of lysozyme activity" EXACT [GOC:TermGenie]
synonym: "up regulation of lysozyme g" RELATED [GOC:TermGenie]
synonym: "up regulation of mucopeptide glucohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of mucopeptide N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of muramidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of N,O-diacetylmuramidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of peptidoglycan N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of PR1-lysozyme" RELATED [GOC:TermGenie]
synonym: "up-regulation of 1,4-N-acetylmuramidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of globulin G" RELATED [GOC:TermGenie]
synonym: "up-regulation of globulin G1" RELATED [GOC:TermGenie]
synonym: "up-regulation of L-7001" RELATED [GOC:TermGenie]
synonym: "up-regulation of lysozyme activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of lysozyme g" RELATED [GOC:TermGenie]
synonym: "up-regulation of mucopeptide glucohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of mucopeptide N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of muramidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of N,O-diacetylmuramidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of peptidoglycan N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of PR1-lysozyme" RELATED [GOC:TermGenie]
synonym: "upregulation of 1,4-N-acetylmuramidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of globulin G" RELATED [GOC:TermGenie]
synonym: "upregulation of globulin G1" RELATED [GOC:TermGenie]
synonym: "upregulation of L-7001" RELATED [GOC:TermGenie]
synonym: "upregulation of lysozyme activity" EXACT [GOC:TermGenie]
synonym: "upregulation of lysozyme g" RELATED [GOC:TermGenie]
synonym: "upregulation of mucopeptide glucohydrolase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of mucopeptide N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of muramidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of N,O-diacetylmuramidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of peptidoglycan N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of PR1-lysozyme" RELATED [GOC:TermGenie]
is_a: GO:0051345 ! positive regulation of hydrolase activity
is_a: GO:1903590 ! regulation of lysozyme activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003796 ! lysozyme activity
relationship: positively_regulates GO:0003796 ! lysozyme activity
created_by: mr
creation_date: 2014-11-05T21:41:39Z

[Term]
id: GO:1903593
name: regulation of histamine secretion by mast cell
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of histamine secretion by mast cell." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18253931]
is_a: GO:0043304 ! regulation of mast cell degranulation
is_a: GO:0044070 ! regulation of anion transport
is_a: GO:0046883 ! regulation of hormone secretion
is_a: GO:0050727 ! regulation of inflammatory response
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002553 ! histamine secretion by mast cell
relationship: regulates GO:0002553 ! histamine secretion by mast cell
created_by: als
creation_date: 2014-11-06T13:19:09Z

[Term]
id: GO:1903594
name: negative regulation of histamine secretion by mast cell
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of histamine secretion by mast cell." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18253931]
synonym: "down regulation of histamine secretion by mast cell" EXACT [GOC:TermGenie]
synonym: "down-regulation of histamine secretion by mast cell" EXACT [GOC:TermGenie]
synonym: "downregulation of histamine secretion by mast cell" EXACT [GOC:TermGenie]
synonym: "inhibition of histamine secretion by mast cell" NARROW [GOC:TermGenie]
is_a: GO:0043305 ! negative regulation of mast cell degranulation
is_a: GO:0046888 ! negative regulation of hormone secretion
is_a: GO:0050728 ! negative regulation of inflammatory response
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1903593 ! regulation of histamine secretion by mast cell
is_a: GO:1903792 ! negative regulation of anion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002553 ! histamine secretion by mast cell
relationship: negatively_regulates GO:0002553 ! histamine secretion by mast cell
created_by: als
creation_date: 2014-11-06T13:19:18Z

[Term]
id: GO:1903595
name: positive regulation of histamine secretion by mast cell
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of histamine secretion by mast cell." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18253931]
synonym: "activation of histamine secretion by mast cell" NARROW [GOC:TermGenie]
synonym: "up regulation of histamine secretion by mast cell" EXACT [GOC:TermGenie]
synonym: "up-regulation of histamine secretion by mast cell" EXACT [GOC:TermGenie]
synonym: "upregulation of histamine secretion by mast cell" EXACT [GOC:TermGenie]
is_a: GO:0043306 ! positive regulation of mast cell degranulation
is_a: GO:0046887 ! positive regulation of hormone secretion
is_a: GO:0050729 ! positive regulation of inflammatory response
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1903593 ! regulation of histamine secretion by mast cell
is_a: GO:1903793 ! positive regulation of anion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002553 ! histamine secretion by mast cell
relationship: positively_regulates GO:0002553 ! histamine secretion by mast cell
created_by: als
creation_date: 2014-11-06T13:19:26Z

[Term]
id: GO:1903596
name: regulation of gap junction assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gap junction assembly." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:25017399]
is_a: GO:1901888 ! regulation of cell junction assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016264 ! gap junction assembly
relationship: regulates GO:0016264 ! gap junction assembly
created_by: rl
creation_date: 2014-11-07T18:51:36Z

[Term]
id: GO:1903597
name: negative regulation of gap junction assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of gap junction assembly." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:25017399]
synonym: "down regulation of gap junction assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of gap junction assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of gap junction assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of gap junction assembly" NARROW [GOC:TermGenie]
is_a: GO:1901889 ! negative regulation of cell junction assembly
is_a: GO:1903596 ! regulation of gap junction assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016264 ! gap junction assembly
relationship: negatively_regulates GO:0016264 ! gap junction assembly
created_by: rl
creation_date: 2014-11-07T18:51:45Z

[Term]
id: GO:1903598
name: positive regulation of gap junction assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of gap junction assembly." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:25017399]
synonym: "activation of gap junction assembly" NARROW [GOC:TermGenie]
synonym: "up regulation of gap junction assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of gap junction assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of gap junction assembly" EXACT [GOC:TermGenie]
is_a: GO:1901890 ! positive regulation of cell junction assembly
is_a: GO:1903596 ! regulation of gap junction assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016264 ! gap junction assembly
relationship: positively_regulates GO:0016264 ! gap junction assembly
created_by: rl
creation_date: 2014-11-07T18:51:53Z

[Term]
id: GO:1903599
name: positive regulation of mitophagy
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitochondrion degradation." [GO_REF:0000058, GOC:autophagy, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:21753002]
comment: An example of this AMBRA1 - human (Q9C0C7) in PMID:21753002 inferred from direct assay
synonym: "activation of mitochondrion degradation" RELATED [GOC:TermGenie]
synonym: "activation of mitophagy" NARROW [GOC:TermGenie]
synonym: "positive regulation of mitochondrial degradation" BROAD [GOC:TermGenie]
synonym: "up regulation of mitochondrion degradation" BROAD [GOC:TermGenie]
synonym: "up regulation of mitophagy" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitochondrion degradation" BROAD [GOC:TermGenie]
synonym: "up-regulation of mitophagy" EXACT [GOC:TermGenie]
synonym: "upregulation of mitochondrion degradation" BROAD [GOC:TermGenie]
synonym: "upregulation of mitophagy" EXACT [GOC:TermGenie]
is_a: GO:0010822 ! positive regulation of mitochondrion organization
is_a: GO:0016239 ! positive regulation of macroautophagy
is_a: GO:1903146 ! regulation of mitophagy
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000422 ! mitophagy
relationship: positively_regulates GO:0000422 ! mitophagy
created_by: pad
creation_date: 2014-11-10T14:25:53Z

[Term]
id: GO:1903600
name: glutaminase complex
namespace: cellular_component
def: "A protein complex which is capable of glutaminase activity." [GO_REF:0000088, GOC:TermGenie, PMID:14764090]
synonym: "Sno1p-Snz1p" EXACT []
is_a: GO:1902494 ! catalytic complex
created_by: ew
creation_date: 2014-11-11T18:41:42Z

[Term]
id: GO:1903601
name: thermospermine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving thermospermine." [GO_REF:0000068, GOC:TermGenie, PMID:24906355]
synonym: "thermospermine metabolism" EXACT [GOC:TermGenie]
is_a: GO:0097164 ! ammonium ion metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process
created_by: tb
creation_date: 2014-11-12T18:47:55Z

[Term]
id: GO:1903602
name: thermospermine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of thermospermine." [GO_REF:0000068, GOC:TermGenie, PMID:24906355]
synonym: "thermospermine breakdown" EXACT [GOC:TermGenie]
synonym: "thermospermine catabolism" EXACT [GOC:TermGenie]
synonym: "thermospermine degradation" EXACT [GOC:TermGenie]
is_a: GO:1901565 ! organonitrogen compound catabolic process
is_a: GO:1903601 ! thermospermine metabolic process
created_by: tb
creation_date: 2014-11-12T18:48:04Z

[Term]
id: GO:1903603
name: thermospermine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of thermospermine." [GO_REF:0000068, GOC:TermGenie, PMID:24906355]
synonym: "thermospermine anabolism" EXACT [GOC:TermGenie]
synonym: "thermospermine biosynthesis" EXACT [GOC:TermGenie]
synonym: "thermospermine formation" EXACT [GOC:TermGenie]
synonym: "thermospermine synthesis" EXACT [GOC:TermGenie]
is_a: GO:1901566 ! organonitrogen compound biosynthetic process
is_a: GO:1903601 ! thermospermine metabolic process
created_by: tb
creation_date: 2014-11-12T18:48:12Z

[Term]
id: GO:1903604
name: cytochrome metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a cytochrome." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:19721088]
synonym: "cytochrome metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019538 ! protein metabolic process
created_by: dph
creation_date: 2014-11-13T20:01:09Z

[Term]
id: GO:1903605
name: cytochrome biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a cytochrome." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:19721088]
synonym: "cytochrome anabolism" EXACT [GOC:TermGenie]
synonym: "cytochrome biosynthesis" EXACT [GOC:TermGenie]
synonym: "cytochrome formation" EXACT [GOC:TermGenie]
synonym: "cytochrome synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009059 ! macromolecule biosynthetic process
is_a: GO:1903604 ! cytochrome metabolic process
created_by: dph
creation_date: 2014-11-13T20:01:18Z

[Term]
id: GO:1903606
name: cytochrome c metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cytochrome c." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:19721088]
synonym: "cytochrome c metabolism" EXACT [GOC:TermGenie]
is_a: GO:1903604 ! cytochrome metabolic process
created_by: dph
creation_date: 2014-11-13T20:01:27Z

[Term]
id: GO:1903607
name: cytochrome c biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cytochrome c." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:19721088]
synonym: "cytochrome c anabolism" EXACT [GOC:TermGenie]
synonym: "cytochrome c biosynthesis" EXACT [GOC:TermGenie]
synonym: "cytochrome c formation" EXACT [GOC:TermGenie]
synonym: "cytochrome c synthesis" EXACT [GOC:TermGenie]
is_a: GO:1903605 ! cytochrome biosynthetic process
is_a: GO:1903606 ! cytochrome c metabolic process
created_by: dph
creation_date: 2014-11-13T20:01:35Z

[Term]
id: GO:1903608
name: protein localization to cytoplasmic stress granule
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a cytoplasmic stress granule." [GO_REF:0000087, GOC:TermGenie, PMID:24755092]
synonym: "protein localisation in cytoplasmic stress granule" EXACT [GOC:TermGenie]
synonym: "protein localisation to cytoplasmic stress granule" EXACT [GOC:TermGenie]
synonym: "protein localization in cytoplasmic stress granule" EXACT [GOC:TermGenie]
synonym: "protein localization to stress granule" BROAD []
is_a: GO:0033365 ! protein localization to organelle
created_by: mah
creation_date: 2014-11-14T16:20:32Z

[Term]
id: GO:1903609
name: negative regulation of inward rectifier potassium channel activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of inward rectifier potassium channel activity." [GO_REF:0000059, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18923542]
synonym: "down regulation of inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of Kir channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of Kir channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of inward rectifier potassium channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of Kir channel activity" EXACT [GOC:TermGenie]
synonym: "inhibition of inward rectifier potassium channel activity" NARROW [GOC:TermGenie]
synonym: "inhibition of Kir channel activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of Kir channel activity" EXACT [GOC:TermGenie]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:1901979 ! regulation of inward rectifier potassium channel activity
is_a: GO:1903817 ! negative regulation of voltage-gated potassium channel activity
is_a: GO:2000272 ! negative regulation of receptor activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0005242 ! inward rectifier potassium channel activity
relationship: negatively_regulates GO:0005242 ! inward rectifier potassium channel activity
created_by: rl
creation_date: 2014-11-14T20:29:14Z

[Term]
id: GO:1903610
name: regulation of calcium-dependent ATPase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of calcium-dependent ATPase activity." [GO_REF:0000059, GOC:TermGenie, PMID:10861851]
is_a: GO:0043462 ! regulation of ATPase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030899 ! calcium-dependent ATPase activity
relationship: regulates GO:0030899 ! calcium-dependent ATPase activity
created_by: sl
creation_date: 2014-11-18T00:42:49Z

[Term]
id: GO:1903611
name: negative regulation of calcium-dependent ATPase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium-dependent ATPase activity." [GO_REF:0000059, GOC:TermGenie, PMID:10861851]
synonym: "down regulation of calcium-dependent ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of calcium-dependent ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of calcium-dependent ATPase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of calcium-dependent ATPase activity" NARROW [GOC:TermGenie]
is_a: GO:0032780 ! negative regulation of ATPase activity
is_a: GO:1903610 ! regulation of calcium-dependent ATPase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030899 ! calcium-dependent ATPase activity
relationship: negatively_regulates GO:0030899 ! calcium-dependent ATPase activity
created_by: sl
creation_date: 2014-11-18T00:42:57Z

[Term]
id: GO:1903612
name: positive regulation of calcium-dependent ATPase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of calcium-dependent ATPase activity." [GO_REF:0000059, GOC:TermGenie, PMID:10861851]
synonym: "activation of calcium-dependent ATPase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of calcium-dependent ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of calcium-dependent ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of calcium-dependent ATPase activity" EXACT [GOC:TermGenie]
is_a: GO:0032781 ! positive regulation of ATPase activity
is_a: GO:1903610 ! regulation of calcium-dependent ATPase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030899 ! calcium-dependent ATPase activity
relationship: positively_regulates GO:0030899 ! calcium-dependent ATPase activity
created_by: sl
creation_date: 2014-11-18T00:43:06Z

[Term]
id: GO:1903613
name: regulation of protein tyrosine phosphatase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein tyrosine phosphatase activity." [GO_REF:0000059, GOC:TermGenie, PMID:11129957]
synonym: "regulation of [phosphotyrosine]protein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "regulation of phosphoprotein phosphatase (phosphotyrosine) activity" EXACT [GOC:TermGenie]
synonym: "regulation of phosphotyrosine histone phosphatase activity" EXACT [GOC:TermGenie]
synonym: "regulation of phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "regulation of phosphotyrosine protein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "regulation of phosphotyrosylprotein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "regulation of PPT-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "regulation of protein phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "regulation of protein-tyrosine-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "regulation of protein-tyrosine-phosphate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "regulation of PTP-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "regulation of PTPase activity" EXACT [GOC:TermGenie]
synonym: "regulation of tyrosine O-phosphate phosphatase activity" EXACT [GOC:TermGenie]
synonym: "regulation of tyrosylprotein phosphatase activity" EXACT [GOC:TermGenie]
is_a: GO:0043666 ! regulation of phosphoprotein phosphatase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004725 ! protein tyrosine phosphatase activity
relationship: regulates GO:0004725 ! protein tyrosine phosphatase activity
created_by: sl
creation_date: 2014-11-18T01:11:38Z

[Term]
id: GO:1903614
name: negative regulation of protein tyrosine phosphatase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein tyrosine phosphatase activity." [GO_REF:0000059, GOC:TermGenie, PMID:11129957]
synonym: "down regulation of [phosphotyrosine]protein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphoprotein phosphatase (phosphotyrosine) activity" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphotyrosine histone phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphotyrosine protein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphotyrosylprotein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of PPT-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of protein phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of protein tyrosine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of protein-tyrosine-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of protein-tyrosine-phosphate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of PTP-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of PTPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of tyrosine O-phosphate phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of tyrosylprotein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of [phosphotyrosine]protein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphoprotein phosphatase (phosphotyrosine) activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphotyrosine histone phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphotyrosine protein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphotyrosylprotein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of PPT-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein tyrosine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein-tyrosine-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein-tyrosine-phosphate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of PTP-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of PTPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of tyrosine O-phosphate phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of tyrosylprotein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of [phosphotyrosine]protein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphoprotein phosphatase (phosphotyrosine) activity" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphotyrosine histone phosphatase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphotyrosine protein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphotyrosylprotein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of PPT-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of protein phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of protein tyrosine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of protein-tyrosine-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of protein-tyrosine-phosphate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of PTP-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of PTPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of tyrosine O-phosphate phosphatase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of tyrosylprotein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of [phosphotyrosine]protein phosphatase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of phosphoprotein phosphatase (phosphotyrosine) activity" NARROW [GOC:TermGenie]
synonym: "inhibition of phosphotyrosine histone phosphatase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of phosphotyrosine phosphatase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of phosphotyrosine protein phosphatase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of phosphotyrosylprotein phosphatase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of PPT-phosphatase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of protein phosphotyrosine phosphatase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of protein tyrosine phosphatase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of protein-tyrosine-phosphatase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of protein-tyrosine-phosphate phosphohydrolase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of PTP-phosphatase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of PTPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of tyrosine O-phosphate phosphatase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of tyrosylprotein phosphatase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of [phosphotyrosine]protein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphoprotein phosphatase (phosphotyrosine) activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphotyrosine histone phosphatase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphotyrosine protein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphotyrosylprotein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of PPT-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein-tyrosine-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein-tyrosine-phosphate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of PTP-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of PTPase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of tyrosine O-phosphate phosphatase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of tyrosylprotein phosphatase activity" EXACT [GOC:TermGenie]
is_a: GO:0032515 ! negative regulation of phosphoprotein phosphatase activity
is_a: GO:1903613 ! regulation of protein tyrosine phosphatase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004725 ! protein tyrosine phosphatase activity
relationship: negatively_regulates GO:0004725 ! protein tyrosine phosphatase activity
created_by: sl
creation_date: 2014-11-18T01:11:46Z

[Term]
id: GO:1903615
name: positive regulation of protein tyrosine phosphatase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein tyrosine phosphatase activity." [GO_REF:0000059, GOC:TermGenie, PMID:11129957]
synonym: "activation of [phosphotyrosine]protein phosphatase activity" NARROW [GOC:TermGenie]
synonym: "activation of phosphoprotein phosphatase (phosphotyrosine) activity" NARROW [GOC:TermGenie]
synonym: "activation of phosphotyrosine histone phosphatase activity" NARROW [GOC:TermGenie]
synonym: "activation of phosphotyrosine phosphatase activity" NARROW [GOC:TermGenie]
synonym: "activation of phosphotyrosine protein phosphatase activity" NARROW [GOC:TermGenie]
synonym: "activation of phosphotyrosylprotein phosphatase activity" NARROW [GOC:TermGenie]
synonym: "activation of PPT-phosphatase activity" NARROW [GOC:TermGenie]
synonym: "activation of protein phosphotyrosine phosphatase activity" NARROW [GOC:TermGenie]
synonym: "activation of protein tyrosine phosphatase activity" NARROW [GOC:TermGenie]
synonym: "activation of protein-tyrosine-phosphatase activity" NARROW [GOC:TermGenie]
synonym: "activation of protein-tyrosine-phosphate phosphohydrolase activity" NARROW [GOC:TermGenie]
synonym: "activation of PTP-phosphatase activity" NARROW [GOC:TermGenie]
synonym: "activation of PTPase activity" NARROW [GOC:TermGenie]
synonym: "activation of tyrosine O-phosphate phosphatase activity" NARROW [GOC:TermGenie]
synonym: "activation of tyrosylprotein phosphatase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of [phosphotyrosine]protein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphoprotein phosphatase (phosphotyrosine) activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphotyrosine histone phosphatase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphotyrosine protein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphotyrosylprotein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of PPT-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein-tyrosine-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein-tyrosine-phosphate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of PTP-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of PTPase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of tyrosine O-phosphate phosphatase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of tyrosylprotein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of [phosphotyrosine]protein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphoprotein phosphatase (phosphotyrosine) activity" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphotyrosine histone phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphotyrosine protein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphotyrosylprotein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of PPT-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of protein phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of protein tyrosine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of protein-tyrosine-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of protein-tyrosine-phosphate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of PTP-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of PTPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of tyrosine O-phosphate phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of tyrosylprotein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of [phosphotyrosine]protein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphoprotein phosphatase (phosphotyrosine) activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphotyrosine histone phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphotyrosine protein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphotyrosylprotein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of PPT-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein tyrosine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein-tyrosine-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein-tyrosine-phosphate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of PTP-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of PTPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of tyrosine O-phosphate phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of tyrosylprotein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of [phosphotyrosine]protein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphoprotein phosphatase (phosphotyrosine) activity" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphotyrosine histone phosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphotyrosine protein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphotyrosylprotein phosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of PPT-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of protein phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of protein tyrosine phosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of protein-tyrosine-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of protein-tyrosine-phosphate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of PTP-phosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of PTPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of tyrosine O-phosphate phosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of tyrosylprotein phosphatase activity" EXACT [GOC:TermGenie]
is_a: GO:0032516 ! positive regulation of phosphoprotein phosphatase activity
is_a: GO:1903613 ! regulation of protein tyrosine phosphatase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004725 ! protein tyrosine phosphatase activity
relationship: positively_regulates GO:0004725 ! protein tyrosine phosphatase activity
created_by: sl
creation_date: 2014-11-18T01:11:55Z

[Term]
id: GO:1903616
name: MAPK cascade involved in axon regeneration
namespace: biological_process
def: "Any MAPK cascade that is involved in axon regeneration." [GO_REF:0000060, GOC:kmv, GOC:TermGenie, PMID:19164707, PMID:19417215, PMID:19737525]
synonym: "ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "MAP kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "MAP kinase kinase kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "MAPK signal transduction involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie]
synonym: "MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie]
synonym: "MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "MAPKKK cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "mitogen-activated protein kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
is_a: GO:0000165 ! MAPK cascade
intersection_of: GO:0000165 ! MAPK cascade
intersection_of: part_of GO:0031103 ! axon regeneration
relationship: part_of GO:0031103 ! axon regeneration
created_by: kmv
creation_date: 2014-11-18T19:11:59Z

[Term]
id: GO:1903617
name: positive regulation of mitotic cytokinesis, site selection
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitotic cytokinesis, site selection." [GO_REF:0000058, GOC:TermGenie, PMID:21246752]
is_a: GO:1902472 ! regulation of mitotic cytokinesis, site selection
is_a: GO:1903438 ! positive regulation of mitotic cytokinetic process
is_a: GO:2000076 ! positive regulation cytokinesis, site selection
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1902408 ! mitotic cytokinesis, site selection
relationship: positively_regulates GO:1902408 ! mitotic cytokinesis, site selection
created_by: vw
creation_date: 2014-11-19T10:52:25Z

[Term]
id: GO:1903618
name: regulation of transdifferentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transdifferentiation." [GO_REF:0000058, GOC:TermGenie, PMID:22118091]
is_a: GO:0045595 ! regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060290 ! transdifferentiation
relationship: regulates GO:0060290 ! transdifferentiation
created_by: jl
creation_date: 2014-11-19T11:24:57Z

[Term]
id: GO:1903619
name: negative regulation of transdifferentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of transdifferentiation." [GO_REF:0000058, GOC:TermGenie, PMID:22118091]
synonym: "down regulation of transdifferentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of transdifferentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of transdifferentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of transdifferentiation" NARROW [GOC:TermGenie]
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:1903618 ! regulation of transdifferentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060290 ! transdifferentiation
relationship: negatively_regulates GO:0060290 ! transdifferentiation
created_by: jl
creation_date: 2014-11-19T11:25:05Z

[Term]
id: GO:1903620
name: positive regulation of transdifferentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transdifferentiation." [GO_REF:0000058, GOC:TermGenie, PMID:22118091]
synonym: "activation of transdifferentiation" NARROW [GOC:TermGenie]
synonym: "up regulation of transdifferentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of transdifferentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of transdifferentiation" EXACT [GOC:TermGenie]
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:1903618 ! regulation of transdifferentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060290 ! transdifferentiation
relationship: positively_regulates GO:0060290 ! transdifferentiation
created_by: jl
creation_date: 2014-11-19T11:25:14Z

[Term]
id: GO:1903621
name: protein localization to photoreceptor connecting cilium
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a photoreceptor connecting cilium." [GO_REF:0000087, GOC:lb, GOC:TermGenie, PMID:25398945]
synonym: "protein localisation in photoreceptor connecting cilium" EXACT [GOC:TermGenie]
synonym: "protein localisation to photoreceptor connecting cilium" EXACT [GOC:TermGenie]
synonym: "protein localization in photoreceptor connecting cilium" EXACT [GOC:TermGenie]
is_a: GO:0097499 ! protein localization to nonmotile primary cilium
created_by: jl
creation_date: 2014-11-19T17:17:17Z

[Term]
id: GO:1903622
name: regulation of RNA polymerase III activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of RNA polymerase III activity." [GO_REF:0000059, GOC:TermGenie, PMID:25392932]
synonym: "regulation of DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter" EXACT [GOC:TermGenie]
is_a: GO:0006359 ! regulation of transcription from RNA polymerase III promoter
is_a: GO:0051338 ! regulation of transferase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001056 ! RNA polymerase III activity
relationship: regulates GO:0001056 ! RNA polymerase III activity
created_by: al
creation_date: 2014-11-19T18:24:29Z

[Term]
id: GO:1903623
name: negative regulation of RNA polymerase III activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA polymerase III activity." [GO_REF:0000059, GOC:TermGenie, PMID:25392932]
synonym: "down regulation of DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter" EXACT [GOC:TermGenie]
synonym: "down regulation of RNA polymerase III activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA polymerase III activity" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA polymerase III activity" EXACT [GOC:TermGenie]
synonym: "inhibition of DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter" NARROW [GOC:TermGenie]
synonym: "inhibition of RNA polymerase III activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter" EXACT [GOC:TermGenie]
is_a: GO:0016480 ! negative regulation of transcription from RNA polymerase III promoter
is_a: GO:0051348 ! negative regulation of transferase activity
is_a: GO:1903622 ! regulation of RNA polymerase III activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001056 ! RNA polymerase III activity
relationship: negatively_regulates GO:0001056 ! RNA polymerase III activity
created_by: al
creation_date: 2014-11-19T18:24:37Z

[Term]
id: GO:1903624
name: regulation of DNA catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:2001740]
synonym: "regulation of DNA breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of DNA catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of DNA degradation" EXACT [GOC:TermGenie]
is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:0051052 ! regulation of DNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006308 ! DNA catabolic process
relationship: regulates GO:0006308 ! DNA catabolic process
created_by: sl
creation_date: 2014-11-19T22:36:35Z

[Term]
id: GO:1903625
name: negative regulation of DNA catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:2001740]
synonym: "down regulation of DNA breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of DNA catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of DNA catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of DNA degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA degradation" EXACT [GOC:TermGenie]
synonym: "inhibition of DNA breakdown" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA degradation" NARROW [GOC:TermGenie]
synonym: "negative regulation of DNA breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of DNA catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of DNA degradation" EXACT [GOC:TermGenie]
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:0051053 ! negative regulation of DNA metabolic process
is_a: GO:1903624 ! regulation of DNA catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006308 ! DNA catabolic process
relationship: negatively_regulates GO:0006308 ! DNA catabolic process
created_by: sl
creation_date: 2014-11-19T22:36:43Z

[Term]
id: GO:1903626
name: positive regulation of DNA catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:2001740]
synonym: "activation of DNA breakdown" NARROW [GOC:TermGenie]
synonym: "activation of DNA catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of DNA catabolism" NARROW [GOC:TermGenie]
synonym: "activation of DNA degradation" NARROW [GOC:TermGenie]
synonym: "positive regulation of DNA breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of DNA catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of DNA degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA degradation" EXACT [GOC:TermGenie]
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:0051054 ! positive regulation of DNA metabolic process
is_a: GO:1903624 ! regulation of DNA catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006308 ! DNA catabolic process
relationship: positively_regulates GO:0006308 ! DNA catabolic process
created_by: sl
creation_date: 2014-11-19T22:36:51Z

[Term]
id: GO:1903627
name: regulation of dUTP diphosphatase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dUTP diphosphatase activity." [GO_REF:0000059, GOC:TermGenie, PMID:1315924]
synonym: "regulation of deoxyuridine-triphosphatase activity" EXACT [GOC:TermGenie]
synonym: "regulation of desoxyuridine 5'-triphosphatase activity" EXACT [GOC:TermGenie]
synonym: "regulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "regulation of dUTP nucleotidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "regulation of dUTP pyrophosphatase activity" EXACT [GOC:TermGenie]
synonym: "regulation of dUTPase activity" EXACT [GOC:TermGenie]
is_a: GO:0051336 ! regulation of hydrolase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004170 ! dUTP diphosphatase activity
relationship: regulates GO:0004170 ! dUTP diphosphatase activity
created_by: sl
creation_date: 2014-11-20T00:00:36Z

[Term]
id: GO:1903628
name: negative regulation of dUTP diphosphatase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of dUTP diphosphatase activity." [GO_REF:0000059, GOC:TermGenie, PMID:1315924]
synonym: "down regulation of deoxyuridine-triphosphatase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of desoxyuridine 5'-triphosphatase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of dUTP diphosphatase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of dUTP nucleotidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of dUTP pyrophosphatase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of dUTPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of deoxyuridine-triphosphatase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of desoxyuridine 5'-triphosphatase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of dUTP diphosphatase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of dUTP nucleotidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of dUTP pyrophosphatase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of dUTPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of deoxyuridine-triphosphatase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of desoxyuridine 5'-triphosphatase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of dUTP diphosphatase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of dUTP nucleotidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of dUTP pyrophosphatase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of dUTPase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of deoxyuridine-triphosphatase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of desoxyuridine 5'-triphosphatase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of desoxyuridine 5'-triphosphate nucleotidohydrolase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of dUTP diphosphatase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of dUTP nucleotidohydrolase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of dUTP pyrophosphatase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of dUTPase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of deoxyuridine-triphosphatase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of desoxyuridine 5'-triphosphatase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of dUTP nucleotidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of dUTP pyrophosphatase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of dUTPase activity" EXACT [GOC:TermGenie]
is_a: GO:0051346 ! negative regulation of hydrolase activity
is_a: GO:1903627 ! regulation of dUTP diphosphatase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004170 ! dUTP diphosphatase activity
relationship: negatively_regulates GO:0004170 ! dUTP diphosphatase activity
created_by: sl
creation_date: 2014-11-20T00:00:44Z

[Term]
id: GO:1903629
name: positive regulation of dUTP diphosphatase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of dUTP diphosphatase activity." [GO_REF:0000059, GOC:TermGenie, PMID:1315924]
synonym: "activation of deoxyuridine-triphosphatase activity" NARROW [GOC:TermGenie]
synonym: "activation of desoxyuridine 5'-triphosphatase activity" NARROW [GOC:TermGenie]
synonym: "activation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity" NARROW [GOC:TermGenie]
synonym: "activation of dUTP diphosphatase activity" NARROW [GOC:TermGenie]
synonym: "activation of dUTP nucleotidohydrolase activity" NARROW [GOC:TermGenie]
synonym: "activation of dUTP pyrophosphatase activity" NARROW [GOC:TermGenie]
synonym: "activation of dUTPase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of deoxyuridine-triphosphatase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of desoxyuridine 5'-triphosphatase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of dUTP nucleotidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of dUTP pyrophosphatase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of dUTPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of deoxyuridine-triphosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of desoxyuridine 5'-triphosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of dUTP diphosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of dUTP nucleotidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of dUTP pyrophosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of dUTPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of deoxyuridine-triphosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of desoxyuridine 5'-triphosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of dUTP diphosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of dUTP nucleotidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of dUTP pyrophosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of dUTPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of deoxyuridine-triphosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of desoxyuridine 5'-triphosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of dUTP diphosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of dUTP nucleotidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of dUTP pyrophosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of dUTPase activity" EXACT [GOC:TermGenie]
is_a: GO:0051345 ! positive regulation of hydrolase activity
is_a: GO:1903627 ! regulation of dUTP diphosphatase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004170 ! dUTP diphosphatase activity
relationship: positively_regulates GO:0004170 ! dUTP diphosphatase activity
created_by: sl
creation_date: 2014-11-20T00:00:56Z

[Term]
id: GO:1903630
name: regulation of aminoacyl-tRNA ligase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of aminoacyl-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:2280766]
synonym: "regulation of aminoacyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of aminoacyl-tRNA synthetase auxiliary protein activity" RELATED [GOC:TermGenie]
is_a: GO:0051340 ! regulation of ligase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004812 ! aminoacyl-tRNA ligase activity
relationship: regulates GO:0004812 ! aminoacyl-tRNA ligase activity
created_by: sl
creation_date: 2014-11-20T00:22:04Z

[Term]
id: GO:1903631
name: negative regulation of aminoacyl-tRNA ligase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of aminoacyl-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:2280766]
synonym: "down regulation of aminoacyl-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of aminoacyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of aminoacyl-tRNA synthetase auxiliary protein activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of aminoacyl-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of aminoacyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of aminoacyl-tRNA synthetase auxiliary protein activity" RELATED [GOC:TermGenie]
synonym: "downregulation of aminoacyl-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of aminoacyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of aminoacyl-tRNA synthetase auxiliary protein activity" RELATED [GOC:TermGenie]
synonym: "inhibition of aminoacyl-tRNA ligase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of aminoacyl-tRNA synthetase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of aminoacyl-tRNA synthetase auxiliary protein activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of aminoacyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of aminoacyl-tRNA synthetase auxiliary protein activity" RELATED [GOC:TermGenie]
is_a: GO:0051352 ! negative regulation of ligase activity
is_a: GO:1903630 ! regulation of aminoacyl-tRNA ligase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004812 ! aminoacyl-tRNA ligase activity
relationship: negatively_regulates GO:0004812 ! aminoacyl-tRNA ligase activity
created_by: sl
creation_date: 2014-11-20T00:22:12Z

[Term]
id: GO:1903632
name: positive regulation of aminoacyl-tRNA ligase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of aminoacyl-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:2280766]
synonym: "activation of aminoacyl-tRNA ligase activity" NARROW [GOC:TermGenie]
synonym: "activation of aminoacyl-tRNA synthetase activity" NARROW [GOC:TermGenie]
synonym: "activation of aminoacyl-tRNA synthetase auxiliary protein activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of aminoacyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of aminoacyl-tRNA synthetase auxiliary protein activity" RELATED [GOC:TermGenie]
synonym: "up regulation of aminoacyl-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of aminoacyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of aminoacyl-tRNA synthetase auxiliary protein activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of aminoacyl-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of aminoacyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of aminoacyl-tRNA synthetase auxiliary protein activity" RELATED [GOC:TermGenie]
synonym: "upregulation of aminoacyl-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of aminoacyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of aminoacyl-tRNA synthetase auxiliary protein activity" RELATED [GOC:TermGenie]
is_a: GO:0051351 ! positive regulation of ligase activity
is_a: GO:1903630 ! regulation of aminoacyl-tRNA ligase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004812 ! aminoacyl-tRNA ligase activity
relationship: positively_regulates GO:0004812 ! aminoacyl-tRNA ligase activity
created_by: sl
creation_date: 2014-11-20T00:22:20Z

[Term]
id: GO:1903633
name: regulation of leucine-tRNA ligase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of leucine-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:2280766]
synonym: "regulation of L-leucine:tRNALeu ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "regulation of leucine translase activity" EXACT [GOC:TermGenie]
synonym: "regulation of leucine-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of leucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of leucyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of leucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of leucyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
is_a: GO:1903630 ! regulation of aminoacyl-tRNA ligase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004823 ! leucine-tRNA ligase activity
relationship: regulates GO:0004823 ! leucine-tRNA ligase activity
created_by: sl
creation_date: 2014-11-20T00:24:48Z

[Term]
id: GO:1903634
name: negative regulation of leucine-tRNA ligase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of leucine-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:2280766]
synonym: "down regulation of L-leucine:tRNALeu ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "down regulation of leucine translase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of leucine-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of leucine-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of leucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of leucyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of leucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of leucyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of L-leucine:tRNALeu ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "down-regulation of leucine translase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of leucine-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of leucine-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of leucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of leucyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of leucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of leucyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of L-leucine:tRNALeu ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "downregulation of leucine translase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of leucine-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of leucine-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of leucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of leucyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of leucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of leucyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of L-leucine:tRNALeu ligase (AMP-forming)" NARROW [GOC:TermGenie]
synonym: "inhibition of leucine translase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of leucine-tRNA ligase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of leucine-tRNA synthetase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of leucyl-transfer ribonucleate synthetase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of leucyl-transfer ribonucleic acid synthetase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of leucyl-transfer RNA synthetase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of leucyl-tRNA synthetase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of L-leucine:tRNALeu ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "negative regulation of leucine translase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of leucine-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of leucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of leucyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of leucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of leucyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
is_a: GO:1903631 ! negative regulation of aminoacyl-tRNA ligase activity
is_a: GO:1903633 ! regulation of leucine-tRNA ligase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004823 ! leucine-tRNA ligase activity
relationship: negatively_regulates GO:0004823 ! leucine-tRNA ligase activity
created_by: sl
creation_date: 2014-11-20T00:24:56Z

[Term]
id: GO:1903635
name: positive regulation of leucine-tRNA ligase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of leucine-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:2280766]
synonym: "activation of L-leucine:tRNALeu ligase (AMP-forming)" NARROW [GOC:TermGenie]
synonym: "activation of leucine translase activity" NARROW [GOC:TermGenie]
synonym: "activation of leucine-tRNA ligase activity" NARROW [GOC:TermGenie]
synonym: "activation of leucine-tRNA synthetase activity" NARROW [GOC:TermGenie]
synonym: "activation of leucyl-transfer ribonucleate synthetase activity" NARROW [GOC:TermGenie]
synonym: "activation of leucyl-transfer ribonucleic acid synthetase activity" NARROW [GOC:TermGenie]
synonym: "activation of leucyl-transfer RNA synthetase activity" NARROW [GOC:TermGenie]
synonym: "activation of leucyl-tRNA synthetase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of L-leucine:tRNALeu ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "positive regulation of leucine translase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of leucine-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of leucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of leucyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of leucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of leucyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of L-leucine:tRNALeu ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "up regulation of leucine translase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of leucine-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of leucine-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of leucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of leucyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of leucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of leucyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-leucine:tRNALeu ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "up-regulation of leucine translase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of leucine-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of leucine-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of leucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of leucyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of leucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of leucyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of L-leucine:tRNALeu ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "upregulation of leucine translase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of leucine-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of leucine-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of leucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of leucyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of leucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of leucyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
is_a: GO:1903632 ! positive regulation of aminoacyl-tRNA ligase activity
is_a: GO:1903633 ! regulation of leucine-tRNA ligase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004823 ! leucine-tRNA ligase activity
relationship: positively_regulates GO:0004823 ! leucine-tRNA ligase activity
created_by: sl
creation_date: 2014-11-20T00:25:08Z

[Term]
id: GO:1903636
name: regulation of protein import into mitochondrial outer membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein import into mitochondrial outer membrane." [GO_REF:0000058, GOC:TermGenie, PMID:16374546]
synonym: "regulation of mitochondrial outer membrane protein import" EXACT [GOC:TermGenie]
synonym: "regulation of protein insertion into mitochondrial outer membrane" EXACT [GOC:TermGenie]
synonym: "regulation of protein transport into mitochondrial outer membrane" EXACT [GOC:TermGenie]
is_a: GO:0034762 ! regulation of transmembrane transport
is_a: GO:1903214 ! regulation of protein targeting to mitochondrion
is_a: GO:1904589 ! regulation of protein import
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045040 ! protein import into mitochondrial outer membrane
relationship: regulates GO:0045040 ! protein import into mitochondrial outer membrane
created_by: pga
creation_date: 2014-11-20T15:54:44Z

[Term]
id: GO:1903637
name: negative regulation of protein import into mitochondrial outer membrane
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein import into mitochondrial outer membrane." [GO_REF:0000058, GOC:TermGenie, PMID:16374546]
synonym: "down regulation of mitochondrial outer membrane protein import" EXACT [GOC:TermGenie]
synonym: "down regulation of protein import into mitochondrial outer membrane" EXACT [GOC:TermGenie]
synonym: "down regulation of protein insertion into mitochondrial outer membrane" EXACT [GOC:TermGenie]
synonym: "down regulation of protein transport into mitochondrial outer membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitochondrial outer membrane protein import" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein import into mitochondrial outer membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein insertion into mitochondrial outer membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein transport into mitochondrial outer membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of mitochondrial outer membrane protein import" EXACT [GOC:TermGenie]
synonym: "downregulation of protein import into mitochondrial outer membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of protein insertion into mitochondrial outer membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of protein transport into mitochondrial outer membrane" EXACT [GOC:TermGenie]
synonym: "inhibition of mitochondrial outer membrane protein import" NARROW [GOC:TermGenie]
synonym: "inhibition of protein import into mitochondrial outer membrane" NARROW [GOC:TermGenie]
synonym: "inhibition of protein insertion into mitochondrial outer membrane" NARROW [GOC:TermGenie]
synonym: "inhibition of protein transport into mitochondrial outer membrane" NARROW [GOC:TermGenie]
synonym: "negative regulation of mitochondrial outer membrane protein import" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein insertion into mitochondrial outer membrane" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein transport into mitochondrial outer membrane" EXACT [GOC:TermGenie]
is_a: GO:0034763 ! negative regulation of transmembrane transport
is_a: GO:1903215 ! negative regulation of protein targeting to mitochondrion
is_a: GO:1903636 ! regulation of protein import into mitochondrial outer membrane
is_a: GO:1904590 ! negative regulation of protein import
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045040 ! protein import into mitochondrial outer membrane
relationship: negatively_regulates GO:0045040 ! protein import into mitochondrial outer membrane
created_by: pga
creation_date: 2014-11-20T15:54:53Z

[Term]
id: GO:1903638
name: positive regulation of protein import into mitochondrial outer membrane
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein import into mitochondrial outer membrane." [GO_REF:0000058, GOC:TermGenie, PMID:16374546]
synonym: "activation of mitochondrial outer membrane protein import" NARROW [GOC:TermGenie]
synonym: "activation of protein import into mitochondrial outer membrane" NARROW [GOC:TermGenie]
synonym: "activation of protein insertion into mitochondrial outer membrane" NARROW [GOC:TermGenie]
synonym: "activation of protein transport into mitochondrial outer membrane" NARROW [GOC:TermGenie]
synonym: "positive regulation of mitochondrial outer membrane protein import" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein insertion into mitochondrial outer membrane" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein transport into mitochondrial outer membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of mitochondrial outer membrane protein import" EXACT [GOC:TermGenie]
synonym: "up regulation of protein import into mitochondrial outer membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of protein insertion into mitochondrial outer membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of protein transport into mitochondrial outer membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitochondrial outer membrane protein import" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein import into mitochondrial outer membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein insertion into mitochondrial outer membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein transport into mitochondrial outer membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of mitochondrial outer membrane protein import" EXACT [GOC:TermGenie]
synonym: "upregulation of protein import into mitochondrial outer membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of protein insertion into mitochondrial outer membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of protein transport into mitochondrial outer membrane" EXACT [GOC:TermGenie]
is_a: GO:0034764 ! positive regulation of transmembrane transport
is_a: GO:1903636 ! regulation of protein import into mitochondrial outer membrane
is_a: GO:1903955 ! positive regulation of protein targeting to mitochondrion
is_a: GO:1904591 ! positive regulation of protein import
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045040 ! protein import into mitochondrial outer membrane
relationship: positively_regulates GO:0045040 ! protein import into mitochondrial outer membrane
created_by: pga
creation_date: 2014-11-20T15:55:01Z

[Term]
id: GO:1903639
name: regulation of gastrin-induced gastric acid secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gastrin-induced gastric acid secretion." [GO_REF:0000058, GOC:TermGenie, PMID:11123201]
is_a: GO:0060453 ! regulation of gastric acid secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001698 ! gastrin-induced gastric acid secretion
relationship: regulates GO:0001698 ! gastrin-induced gastric acid secretion
created_by: sl
creation_date: 2014-11-20T20:54:20Z

[Term]
id: GO:1903640
name: negative regulation of gastrin-induced gastric acid secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of gastrin-induced gastric acid secretion." [GO_REF:0000058, GOC:TermGenie, PMID:11123201]
synonym: "down regulation of gastrin-induced gastric acid secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of gastrin-induced gastric acid secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of gastrin-induced gastric acid secretion" EXACT [GOC:TermGenie]
synonym: "inhibition of gastrin-induced gastric acid secretion" NARROW [GOC:TermGenie]
is_a: GO:0060455 ! negative regulation of gastric acid secretion
is_a: GO:1903639 ! regulation of gastrin-induced gastric acid secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001698 ! gastrin-induced gastric acid secretion
relationship: negatively_regulates GO:0001698 ! gastrin-induced gastric acid secretion
created_by: sl
creation_date: 2014-11-20T20:54:28Z

[Term]
id: GO:1903641
name: positive regulation of gastrin-induced gastric acid secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of gastrin-induced gastric acid secretion." [GO_REF:0000058, GOC:TermGenie, PMID:11123201]
synonym: "activation of gastrin-induced gastric acid secretion" NARROW [GOC:TermGenie]
synonym: "up regulation of gastrin-induced gastric acid secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of gastrin-induced gastric acid secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of gastrin-induced gastric acid secretion" EXACT [GOC:TermGenie]
is_a: GO:0060454 ! positive regulation of gastric acid secretion
is_a: GO:1903639 ! regulation of gastrin-induced gastric acid secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001698 ! gastrin-induced gastric acid secretion
relationship: positively_regulates GO:0001698 ! gastrin-induced gastric acid secretion
created_by: sl
creation_date: 2014-11-20T20:54:37Z

[Term]
id: GO:1903642
name: regulation of recombination hotspot binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of recombination hotspot binding." [GO_REF:0000059, GOC:TermGenie, PMID:19436749]
synonym: "regulation of DNA binding, recombination hotspot" EXACT [GOC:TermGenie]
is_a: GO:0051101 ! regulation of DNA binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010844 ! recombination hotspot binding
relationship: regulates GO:0010844 ! recombination hotspot binding
created_by: al
creation_date: 2014-11-21T12:02:22Z

[Term]
id: GO:1903643
name: positive regulation of recombination hotspot binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of recombination hotspot binding." [GO_REF:0000059, GOC:TermGenie, PMID:19436749]
synonym: "activation of DNA binding, recombination hotspot" NARROW [GOC:TermGenie]
synonym: "activation of recombination hotspot binding" NARROW [GOC:TermGenie]
synonym: "positive regulation of DNA binding, recombination hotspot" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA binding, recombination hotspot" EXACT [GOC:TermGenie]
synonym: "up regulation of recombination hotspot binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA binding, recombination hotspot" EXACT [GOC:TermGenie]
synonym: "up-regulation of recombination hotspot binding" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA binding, recombination hotspot" EXACT [GOC:TermGenie]
synonym: "upregulation of recombination hotspot binding" EXACT [GOC:TermGenie]
is_a: GO:0043388 ! positive regulation of DNA binding
is_a: GO:1903642 ! regulation of recombination hotspot binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010844 ! recombination hotspot binding
relationship: positively_regulates GO:0010844 ! recombination hotspot binding
created_by: al
creation_date: 2014-11-21T12:02:31Z

[Term]
id: GO:1903644
name: regulation of chaperone-mediated protein folding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chaperone-mediated protein folding." [GO_REF:0000058, GOC:TermGenie, PMID:24375412]
is_a: GO:1903332 ! regulation of protein folding
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061077 ! chaperone-mediated protein folding
relationship: regulates GO:0061077 ! chaperone-mediated protein folding
created_by: pga
creation_date: 2014-11-21T15:25:27Z

[Term]
id: GO:1903645
name: negative regulation of chaperone-mediated protein folding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chaperone-mediated protein folding." [GO_REF:0000058, GOC:TermGenie, PMID:24375412]
synonym: "down regulation of chaperone-mediated protein folding" EXACT [GOC:TermGenie]
synonym: "down-regulation of chaperone-mediated protein folding" EXACT [GOC:TermGenie]
synonym: "downregulation of chaperone-mediated protein folding" EXACT [GOC:TermGenie]
synonym: "inhibition of chaperone-mediated protein folding" NARROW [GOC:TermGenie]
is_a: GO:1903333 ! negative regulation of protein folding
is_a: GO:1903644 ! regulation of chaperone-mediated protein folding
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061077 ! chaperone-mediated protein folding
relationship: negatively_regulates GO:0061077 ! chaperone-mediated protein folding
created_by: pga
creation_date: 2014-11-21T15:25:35Z

[Term]
id: GO:1903646
name: positive regulation of chaperone-mediated protein folding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chaperone-mediated protein folding." [GO_REF:0000058, GOC:TermGenie, PMID:24375412]
synonym: "activation of chaperone-mediated protein folding" NARROW [GOC:TermGenie]
synonym: "up regulation of chaperone-mediated protein folding" EXACT [GOC:TermGenie]
synonym: "up-regulation of chaperone-mediated protein folding" EXACT [GOC:TermGenie]
synonym: "upregulation of chaperone-mediated protein folding" EXACT [GOC:TermGenie]
is_a: GO:1903334 ! positive regulation of protein folding
is_a: GO:1903644 ! regulation of chaperone-mediated protein folding
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061077 ! chaperone-mediated protein folding
relationship: positively_regulates GO:0061077 ! chaperone-mediated protein folding
created_by: pga
creation_date: 2014-11-21T15:25:44Z

[Term]
id: GO:1903647
name: negative regulation of chlorophyll catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chlorophyll catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:24719469]
synonym: "down regulation of chlorophyll breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of chlorophyll catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of chlorophyll catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of chlorophyll degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of chlorophyll breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of chlorophyll catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of chlorophyll catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of chlorophyll degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of chlorophyll breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of chlorophyll catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of chlorophyll catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of chlorophyll degradation" EXACT [GOC:TermGenie]
synonym: "inhibition of chlorophyll breakdown" NARROW [GOC:TermGenie]
synonym: "inhibition of chlorophyll catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of chlorophyll catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of chlorophyll degradation" NARROW [GOC:TermGenie]
synonym: "negative regulation of chlorophyll breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of chlorophyll catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of chlorophyll degradation" EXACT [GOC:TermGenie]
is_a: GO:0010271 ! regulation of chlorophyll catabolic process
is_a: GO:0051195 ! negative regulation of cofactor metabolic process
is_a: GO:1901405 ! negative regulation of tetrapyrrole catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0015996 ! chlorophyll catabolic process
relationship: negatively_regulates GO:0015996 ! chlorophyll catabolic process
created_by: tb
creation_date: 2014-11-22T00:18:25Z

[Term]
id: GO:1903648
name: positive regulation of chlorophyll catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chlorophyll catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:24719469]
synonym: "activation of chlorophyll breakdown" NARROW [GOC:TermGenie]
synonym: "activation of chlorophyll catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of chlorophyll catabolism" NARROW [GOC:TermGenie]
synonym: "activation of chlorophyll degradation" NARROW [GOC:TermGenie]
synonym: "positive regulation of chlorophyll breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of chlorophyll catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of chlorophyll degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of chlorophyll breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of chlorophyll catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of chlorophyll catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of chlorophyll degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of chlorophyll breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of chlorophyll catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of chlorophyll catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of chlorophyll degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of chlorophyll breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of chlorophyll catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of chlorophyll catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of chlorophyll degradation" EXACT [GOC:TermGenie]
is_a: GO:0010271 ! regulation of chlorophyll catabolic process
is_a: GO:0051194 ! positive regulation of cofactor metabolic process
is_a: GO:1901406 ! positive regulation of tetrapyrrole catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0015996 ! chlorophyll catabolic process
relationship: positively_regulates GO:0015996 ! chlorophyll catabolic process
created_by: tb
creation_date: 2014-11-22T00:18:34Z

[Term]
id: GO:1903649
name: regulation of cytoplasmic transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cytoplasmic transport." [GO_REF:0000058, GOC:TermGenie, PMID:25049409]
synonym: "regulation of cytoplasmic streaming" NARROW [GOC:TermGenie]
is_a: GO:0032386 ! regulation of intracellular transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016482 ! cytosolic transport
relationship: regulates GO:0016482 ! cytosolic transport
created_by: jl
creation_date: 2014-11-24T13:38:17Z

[Term]
id: GO:1903650
name: negative regulation of cytoplasmic transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic transport." [GO_REF:0000058, GOC:TermGenie, PMID:25049409]
synonym: "down regulation of cytoplasmic streaming" NARROW [GOC:TermGenie]
synonym: "down regulation of cytoplasmic transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of cytoplasmic streaming" NARROW [GOC:TermGenie]
synonym: "down-regulation of cytoplasmic transport" EXACT [GOC:TermGenie]
synonym: "downregulation of cytoplasmic streaming" NARROW [GOC:TermGenie]
synonym: "downregulation of cytoplasmic transport" EXACT [GOC:TermGenie]
synonym: "inhibition of cytoplasmic streaming" NARROW [GOC:TermGenie]
synonym: "inhibition of cytoplasmic transport" NARROW [GOC:TermGenie]
synonym: "negative regulation of cytoplasmic streaming" NARROW [GOC:TermGenie]
is_a: GO:0032387 ! negative regulation of intracellular transport
is_a: GO:1903649 ! regulation of cytoplasmic transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016482 ! cytosolic transport
relationship: negatively_regulates GO:0016482 ! cytosolic transport
created_by: jl
creation_date: 2014-11-24T13:38:26Z

[Term]
id: GO:1903651
name: positive regulation of cytoplasmic transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cytoplasmic transport." [GO_REF:0000058, GOC:TermGenie, PMID:25049409]
synonym: "activation of cytoplasmic streaming" NARROW [GOC:TermGenie]
synonym: "activation of cytoplasmic transport" NARROW [GOC:TermGenie]
synonym: "positive regulation of cytoplasmic streaming" NARROW [GOC:TermGenie]
synonym: "up regulation of cytoplasmic streaming" NARROW [GOC:TermGenie]
synonym: "up regulation of cytoplasmic transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of cytoplasmic streaming" NARROW [GOC:TermGenie]
synonym: "up-regulation of cytoplasmic transport" EXACT [GOC:TermGenie]
synonym: "upregulation of cytoplasmic streaming" NARROW [GOC:TermGenie]
synonym: "upregulation of cytoplasmic transport" EXACT [GOC:TermGenie]
is_a: GO:0032388 ! positive regulation of intracellular transport
is_a: GO:1903649 ! regulation of cytoplasmic transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016482 ! cytosolic transport
relationship: positively_regulates GO:0016482 ! cytosolic transport
created_by: jl
creation_date: 2014-11-24T13:38:34Z

[Term]
id: GO:1903652
name: modulation by virus of host cytoplasmic transport
namespace: biological_process
def: "Modulation by an infecting virus of host cytoplasmic transport." [GO_REF:0000063, GOC:TermGenie, PMID:25049409]
synonym: "regulation by virus of host cytoplasmic streaming" EXACT []
synonym: "regulation by virus of host cytoplasmic transport" EXACT []
synonym: "viral modulation of host cytoplasmic trafficking" EXACT []
is_a: GO:0019054 ! modulation by virus of host process
is_a: GO:0052038 ! modulation by symbiont of host intracellular transport
is_a: GO:1903649 ! regulation of cytoplasmic transport
intersection_of: GO:0019054 ! modulation by virus of host process
intersection_of: regulates GO:0016482 ! cytosolic transport
relationship: regulates GO:0016482 ! cytosolic transport
created_by: jl
creation_date: 2014-11-24T17:22:04Z

[Term]
id: GO:1903653
name: modulation by symbiont of host cell motility
namespace: biological_process
def: "Modulation of host cell motility by a symbiont of that host." [GO_REF:0000063, GOC:TermGenie, PMID:25049409]
synonym: "modulation by symbiont of host cell locomotion" EXACT []
synonym: "modulation by symbiont of host cell movement" RELATED []
synonym: "regulation by symbiont of host cell motility" EXACT []
is_a: GO:0044068 ! modulation by symbiont of host cellular process
is_a: GO:2000145 ! regulation of cell motility
intersection_of: GO:0044068 ! modulation by symbiont of host cellular process
intersection_of: regulates GO:0048870 ! cell motility
relationship: regulates GO:0048870 ! cell motility
created_by: jl
creation_date: 2014-11-24T17:37:56Z

[Term]
id: GO:1903654
name: phosphorylation of RNA polymerase II C-terminal domain serine 5 residues involved in positive regulation of transcription elongation from RNA polymerase II promoter
namespace: biological_process
def: "Any phosphorylation of RNA polymerase II C-terminal domain serine 5 residues that is involved in positive regulation of transcription elongation from RNA polymerase II promoter." [GO_REF:0000060, GOC:TermGenie, PMID:19328067]
is_a: GO:0071620 ! phosphorylation of RNA polymerase II C-terminal domain serine 5 residues
intersection_of: GO:0071620 ! phosphorylation of RNA polymerase II C-terminal domain serine 5 residues
intersection_of: part_of GO:0032968 ! positive regulation of transcription elongation from RNA polymerase II promoter
relationship: part_of GO:0032968 ! positive regulation of transcription elongation from RNA polymerase II promoter
created_by: vw
creation_date: 2014-11-25T11:00:43Z

[Term]
id: GO:1903655
name: phosphorylation of RNA polymerase II C-terminal domain serine 2 residues involved in positive regulation of transcription elongation from RNA polymerase II promoter
namespace: biological_process
def: "Any phosphorylation of RNA polymerase II C-terminal domain serine 2 residues that is involved in positive regulation of transcription elongation from RNA polymerase II promoter." [GO_REF:0000060, GOC:TermGenie, PMID:19328067]
is_a: GO:0071619 ! phosphorylation of RNA polymerase II C-terminal domain serine 2 residues
intersection_of: GO:0071619 ! phosphorylation of RNA polymerase II C-terminal domain serine 2 residues
intersection_of: part_of GO:0032968 ! positive regulation of transcription elongation from RNA polymerase II promoter
relationship: part_of GO:0032968 ! positive regulation of transcription elongation from RNA polymerase II promoter
created_by: vw
creation_date: 2014-11-25T11:04:16Z

[Term]
id: GO:1903656
name: regulation of type IV pilus biogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of type IV pilus biogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:25049409]
synonym: "regulation of TFP biogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of type 4 pilus biogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of type IV fimbria assembly" EXACT [GOC:TermGenie]
synonym: "regulation of type IV fimbria biogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of type IV fimbriae assembly" EXACT [GOC:TermGenie]
synonym: "regulation of type IV fimbriae biogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of type IV fimbrial assembly" EXACT [GOC:TermGenie]
synonym: "regulation of type IV fimbrial biogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of type IV fimbrium assembly" EXACT [GOC:TermGenie]
synonym: "regulation of type IV fimbrium biogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of type IV pilus biosynthesis" EXACT [GOC:TermGenie]
is_a: GO:0060491 ! regulation of cell projection assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043683 ! type IV pilus biogenesis
relationship: regulates GO:0043683 ! type IV pilus biogenesis
created_by: jl
creation_date: 2014-11-25T12:03:09Z

[Term]
id: GO:1903657
name: negative regulation of type IV pilus biogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of type IV pilus biogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:25049409]
synonym: "down regulation of TFP biogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of type 4 pilus biogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of type IV fimbria assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of type IV fimbria biogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of type IV fimbriae assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of type IV fimbriae biogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of type IV fimbrial assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of type IV fimbrial biogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of type IV fimbrium assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of type IV fimbrium biogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of type IV pilus biogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of type IV pilus biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of TFP biogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of type 4 pilus biogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of type IV fimbria assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of type IV fimbria biogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of type IV fimbriae assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of type IV fimbriae biogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of type IV fimbrial assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of type IV fimbrial biogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of type IV fimbrium assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of type IV fimbrium biogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of type IV pilus biogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of type IV pilus biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of TFP biogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of type 4 pilus biogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of type IV fimbria assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of type IV fimbria biogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of type IV fimbriae assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of type IV fimbriae biogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of type IV fimbrial assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of type IV fimbrial biogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of type IV fimbrium assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of type IV fimbrium biogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of type IV pilus biogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of type IV pilus biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of TFP biogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of type 4 pilus biogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of type IV fimbria assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of type IV fimbria biogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of type IV fimbriae assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of type IV fimbriae biogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of type IV fimbrial assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of type IV fimbrial biogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of type IV fimbrium assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of type IV fimbrium biogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of type IV pilus biogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of type IV pilus biosynthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of TFP biogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of type 4 pilus biogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of type IV fimbria assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of type IV fimbria biogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of type IV fimbriae assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of type IV fimbriae biogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of type IV fimbrial assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of type IV fimbrial biogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of type IV fimbrium assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of type IV fimbrium biogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of type IV pilus biosynthesis" EXACT [GOC:TermGenie]
is_a: GO:0031345 ! negative regulation of cell projection organization
is_a: GO:1903656 ! regulation of type IV pilus biogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043683 ! type IV pilus biogenesis
relationship: negatively_regulates GO:0043683 ! type IV pilus biogenesis
created_by: jl
creation_date: 2014-11-25T12:03:24Z

[Term]
id: GO:1903658
name: positive regulation of type IV pilus biogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of type IV pilus biogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:25049409]
synonym: "activation of TFP biogenesis" NARROW [GOC:TermGenie]
synonym: "activation of type 4 pilus biogenesis" NARROW [GOC:TermGenie]
synonym: "activation of type IV fimbria assembly" NARROW [GOC:TermGenie]
synonym: "activation of type IV fimbria biogenesis" NARROW [GOC:TermGenie]
synonym: "activation of type IV fimbriae assembly" NARROW [GOC:TermGenie]
synonym: "activation of type IV fimbriae biogenesis" NARROW [GOC:TermGenie]
synonym: "activation of type IV fimbrial assembly" NARROW [GOC:TermGenie]
synonym: "activation of type IV fimbrial biogenesis" NARROW [GOC:TermGenie]
synonym: "activation of type IV fimbrium assembly" NARROW [GOC:TermGenie]
synonym: "activation of type IV fimbrium biogenesis" NARROW [GOC:TermGenie]
synonym: "activation of type IV pilus biogenesis" NARROW [GOC:TermGenie]
synonym: "activation of type IV pilus biosynthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of TFP biogenesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of type 4 pilus biogenesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of type IV fimbria assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of type IV fimbria biogenesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of type IV fimbriae assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of type IV fimbriae biogenesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of type IV fimbrial assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of type IV fimbrial biogenesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of type IV fimbrium assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of type IV fimbrium biogenesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of type IV pilus biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of TFP biogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of type 4 pilus biogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of type IV fimbria assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of type IV fimbria biogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of type IV fimbriae assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of type IV fimbriae biogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of type IV fimbrial assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of type IV fimbrial biogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of type IV fimbrium assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of type IV fimbrium biogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of type IV pilus biogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of type IV pilus biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of TFP biogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of type 4 pilus biogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of type IV fimbria assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of type IV fimbria biogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of type IV fimbriae assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of type IV fimbriae biogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of type IV fimbrial assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of type IV fimbrial biogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of type IV fimbrium assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of type IV fimbrium biogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of type IV pilus biogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of type IV pilus biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of TFP biogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of type 4 pilus biogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of type IV fimbria assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of type IV fimbria biogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of type IV fimbriae assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of type IV fimbriae biogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of type IV fimbrial assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of type IV fimbrial biogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of type IV fimbrium assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of type IV fimbrium biogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of type IV pilus biogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of type IV pilus biosynthesis" EXACT [GOC:TermGenie]
is_a: GO:0031346 ! positive regulation of cell projection organization
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:1903656 ! regulation of type IV pilus biogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043683 ! type IV pilus biogenesis
relationship: positively_regulates GO:0043683 ! type IV pilus biogenesis
created_by: jl
creation_date: 2014-11-25T12:03:34Z

[Term]
id: GO:1903659
name: regulation of complement-dependent cytotoxicity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of complement-dependent cytotoxicity." [GO_REF:0000058, GOC:TermGenie, PMID:24280217]
is_a: GO:0031341 ! regulation of cell killing
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097278 ! complement-dependent cytotoxicity
relationship: regulates GO:0097278 ! complement-dependent cytotoxicity
created_by: jl
creation_date: 2014-11-25T15:03:54Z

[Term]
id: GO:1903660
name: negative regulation of complement-dependent cytotoxicity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of complement-dependent cytotoxicity." [GO_REF:0000058, GOC:TermGenie, PMID:24280217]
synonym: "down regulation of complement-dependent cytotoxicity" EXACT [GOC:TermGenie]
synonym: "down-regulation of complement-dependent cytotoxicity" EXACT [GOC:TermGenie]
synonym: "downregulation of complement-dependent cytotoxicity" EXACT [GOC:TermGenie]
synonym: "inhibition of complement-dependent cytotoxicity" NARROW [GOC:TermGenie]
is_a: GO:0031342 ! negative regulation of cell killing
is_a: GO:1903659 ! regulation of complement-dependent cytotoxicity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097278 ! complement-dependent cytotoxicity
relationship: negatively_regulates GO:0097278 ! complement-dependent cytotoxicity
created_by: jl
creation_date: 2014-11-25T15:04:02Z

[Term]
id: GO:1903661
name: positive regulation of complement-dependent cytotoxicity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of complement-dependent cytotoxicity." [GO_REF:0000058, GOC:TermGenie, PMID:24280217]
synonym: "activation of complement-dependent cytotoxicity" NARROW [GOC:TermGenie]
synonym: "up regulation of complement-dependent cytotoxicity" EXACT [GOC:TermGenie]
synonym: "up-regulation of complement-dependent cytotoxicity" EXACT [GOC:TermGenie]
synonym: "upregulation of complement-dependent cytotoxicity" EXACT [GOC:TermGenie]
is_a: GO:0031343 ! positive regulation of cell killing
is_a: GO:1903659 ! regulation of complement-dependent cytotoxicity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097278 ! complement-dependent cytotoxicity
relationship: positively_regulates GO:0097278 ! complement-dependent cytotoxicity
created_by: jl
creation_date: 2014-11-25T15:04:11Z

[Term]
id: GO:1903662
name: L-altrarate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving L-altrarate." [GO_REF:0000068, GOC:TermGenie, PMID:17649980]
synonym: "L-altrarate(1-) metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019577 ! aldaric acid metabolic process
created_by: jl
creation_date: 2014-11-26T14:34:20Z

[Term]
id: GO:1903663
name: L-altrarate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-altrarate." [GO_REF:0000068, GOC:TermGenie, PMID:17649980]
synonym: "L-altrarate(1-) breakdown" EXACT [GOC:TermGenie]
synonym: "L-altrarate(1-) catabolism" EXACT [GOC:TermGenie]
synonym: "L-altrarate(1-) degradation" EXACT [GOC:TermGenie]
is_a: GO:0019579 ! aldaric acid catabolic process
is_a: GO:1903662 ! L-altrarate metabolic process
created_by: jl
creation_date: 2014-11-26T14:34:28Z

[Term]
id: GO:1903664
name: regulation of asexual reproduction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of asexual reproduction." [GO_REF:0000058, GOC:TermGenie, PMID:24390142]
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019954 ! asexual reproduction
relationship: regulates GO:0019954 ! asexual reproduction
created_by: pf
creation_date: 2014-11-26T21:13:24Z

[Term]
id: GO:1903665
name: negative regulation of asexual reproduction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of asexual reproduction." [GO_REF:0000058, GOC:TermGenie, PMID:24390142]
synonym: "down regulation of asexual reproduction" EXACT [GOC:TermGenie]
synonym: "down-regulation of asexual reproduction" EXACT [GOC:TermGenie]
synonym: "downregulation of asexual reproduction" EXACT [GOC:TermGenie]
synonym: "inhibition of asexual reproduction" NARROW [GOC:TermGenie]
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:1903664 ! regulation of asexual reproduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019954 ! asexual reproduction
relationship: negatively_regulates GO:0019954 ! asexual reproduction
created_by: pf
creation_date: 2014-11-26T21:13:32Z

[Term]
id: GO:1903666
name: positive regulation of asexual reproduction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of asexual reproduction." [GO_REF:0000058, GOC:TermGenie, PMID:24390142]
synonym: "activation of asexual reproduction" NARROW [GOC:TermGenie]
synonym: "up regulation of asexual reproduction" EXACT [GOC:TermGenie]
synonym: "up-regulation of asexual reproduction" EXACT [GOC:TermGenie]
synonym: "upregulation of asexual reproduction" EXACT [GOC:TermGenie]
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:1903664 ! regulation of asexual reproduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0019954 ! asexual reproduction
relationship: positively_regulates GO:0019954 ! asexual reproduction
created_by: pf
creation_date: 2014-11-26T21:13:40Z

[Term]
id: GO:1903667
name: regulation of chemorepellent activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chemorepellent activity." [GO_REF:0000059, GOC:TermGenie, PMID:22711818, PMID:24390142]
synonym: "regulation of chemorepellant activity" EXACT [GOC:TermGenie]
is_a: GO:0050923 ! regulation of negative chemotaxis
is_a: GO:0065009 ! regulation of molecular function
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045499 ! chemorepellent activity
relationship: regulates GO:0045499 ! chemorepellent activity
created_by: pf
creation_date: 2014-11-26T23:58:33Z

[Term]
id: GO:1903668
name: negative regulation of chemorepellent activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chemorepellent activity." [GO_REF:0000059, GOC:TermGenie, PMID:22711818, PMID:24390142]
synonym: "down regulation of chemorepellant activity" EXACT [GOC:TermGenie]
synonym: "down regulation of chemorepellent activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of chemorepellant activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of chemorepellent activity" EXACT [GOC:TermGenie]
synonym: "downregulation of chemorepellant activity" EXACT [GOC:TermGenie]
synonym: "downregulation of chemorepellent activity" EXACT [GOC:TermGenie]
synonym: "inhibition of chemorepellant activity" NARROW [GOC:TermGenie]
synonym: "inhibition of chemorepellent activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of chemorepellant activity" EXACT [GOC:TermGenie]
is_a: GO:0044092 ! negative regulation of molecular function
is_a: GO:0050925 ! negative regulation of negative chemotaxis
is_a: GO:1903667 ! regulation of chemorepellent activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045499 ! chemorepellent activity
relationship: negatively_regulates GO:0045499 ! chemorepellent activity
created_by: pf
creation_date: 2014-11-26T23:58:42Z

[Term]
id: GO:1903669
name: positive regulation of chemorepellent activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chemorepellent activity." [GO_REF:0000059, GOC:TermGenie, PMID:22711818, PMID:24390142]
synonym: "activation of chemorepellant activity" NARROW [GOC:TermGenie]
synonym: "activation of chemorepellent activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of chemorepellant activity" EXACT [GOC:TermGenie]
synonym: "up regulation of chemorepellant activity" EXACT [GOC:TermGenie]
synonym: "up regulation of chemorepellent activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of chemorepellant activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of chemorepellent activity" EXACT [GOC:TermGenie]
synonym: "upregulation of chemorepellant activity" EXACT [GOC:TermGenie]
synonym: "upregulation of chemorepellent activity" EXACT [GOC:TermGenie]
is_a: GO:0044093 ! positive regulation of molecular function
is_a: GO:0050924 ! positive regulation of negative chemotaxis
is_a: GO:1903667 ! regulation of chemorepellent activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045499 ! chemorepellent activity
relationship: positively_regulates GO:0045499 ! chemorepellent activity
created_by: pf
creation_date: 2014-11-26T23:58:50Z

[Term]
id: GO:1903670
name: regulation of sprouting angiogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sprouting angiogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:16756958]
is_a: GO:0045765 ! regulation of angiogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002040 ! sprouting angiogenesis
relationship: regulates GO:0002040 ! sprouting angiogenesis
created_by: pga
creation_date: 2014-11-27T10:10:51Z

[Term]
id: GO:1903671
name: negative regulation of sprouting angiogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sprouting angiogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:16756958]
synonym: "down regulation of sprouting angiogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of sprouting angiogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of sprouting angiogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of sprouting angiogenesis" NARROW [GOC:TermGenie]
is_a: GO:0016525 ! negative regulation of angiogenesis
is_a: GO:1903670 ! regulation of sprouting angiogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002040 ! sprouting angiogenesis
relationship: negatively_regulates GO:0002040 ! sprouting angiogenesis
created_by: pga
creation_date: 2014-11-27T10:10:59Z

[Term]
id: GO:1903672
name: positive regulation of sprouting angiogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sprouting angiogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:16756958]
synonym: "activation of sprouting angiogenesis" NARROW [GOC:TermGenie]
synonym: "up regulation of sprouting angiogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of sprouting angiogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of sprouting angiogenesis" EXACT [GOC:TermGenie]
is_a: GO:0045766 ! positive regulation of angiogenesis
is_a: GO:1903670 ! regulation of sprouting angiogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002040 ! sprouting angiogenesis
relationship: positively_regulates GO:0002040 ! sprouting angiogenesis
created_by: pga
creation_date: 2014-11-27T10:11:08Z

[Term]
id: GO:1903673
name: mitotic cleavage furrow formation
namespace: biological_process
def: "Any cleavage furrow formation that is involved in mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "cleavage furrow positioning involved in mitotic cell cycle" NARROW [GOC:TermGenie]
is_a: GO:0036089 ! cleavage furrow formation
is_a: GO:1902410 ! mitotic cytokinetic process
intersection_of: GO:0036089 ! cleavage furrow formation
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0000278 ! mitotic cell cycle
created_by: jl
creation_date: 2014-11-27T15:32:18Z

[Term]
id: GO:1903674
name: regulation of cap-dependent translational initiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cap-dependent translational initiation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
is_a: GO:1904688 ! regulation of cytoplasmic translational initiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002191 ! cap-dependent translational initiation
relationship: regulates GO:0002191 ! cap-dependent translational initiation
created_by: bf
creation_date: 2014-11-27T19:50:23Z

[Term]
id: GO:1903675
name: negative regulation of cap-dependent translational initiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cap-dependent translational initiation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "down regulation of cap-dependent translational initiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of cap-dependent translational initiation" EXACT [GOC:TermGenie]
synonym: "downregulation of cap-dependent translational initiation" EXACT [GOC:TermGenie]
synonym: "inhibition of cap-dependent translational initiation" NARROW [GOC:TermGenie]
is_a: GO:1903674 ! regulation of cap-dependent translational initiation
is_a: GO:1904689 ! negative regulation of cytoplasmic translational initiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002191 ! cap-dependent translational initiation
relationship: negatively_regulates GO:0002191 ! cap-dependent translational initiation
created_by: bf
creation_date: 2014-11-27T19:50:31Z

[Term]
id: GO:1903676
name: positive regulation of cap-dependent translational initiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cap-dependent translational initiation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11959995]
synonym: "activation of cap-dependent translational initiation" NARROW [GOC:TermGenie]
synonym: "up regulation of cap-dependent translational initiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of cap-dependent translational initiation" EXACT [GOC:TermGenie]
synonym: "upregulation of cap-dependent translational initiation" EXACT [GOC:TermGenie]
is_a: GO:1903674 ! regulation of cap-dependent translational initiation
is_a: GO:1904690 ! positive regulation of cytoplasmic translational initiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002191 ! cap-dependent translational initiation
relationship: positively_regulates GO:0002191 ! cap-dependent translational initiation
created_by: bf
creation_date: 2014-11-27T19:50:39Z

[Term]
id: GO:1903677
name: regulation of cap-independent translational initiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cap-independent translational initiation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
is_a: GO:1904688 ! regulation of cytoplasmic translational initiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002190 ! cap-independent translational initiation
relationship: regulates GO:0002190 ! cap-independent translational initiation
created_by: bf
creation_date: 2014-11-27T19:52:20Z

[Term]
id: GO:1903678
name: negative regulation of cap-independent translational initiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cap-independent translational initiation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "down regulation of cap-independent translational initiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of cap-independent translational initiation" EXACT [GOC:TermGenie]
synonym: "downregulation of cap-independent translational initiation" EXACT [GOC:TermGenie]
synonym: "inhibition of cap-independent translational initiation" NARROW [GOC:TermGenie]
is_a: GO:1903677 ! regulation of cap-independent translational initiation
is_a: GO:1904689 ! negative regulation of cytoplasmic translational initiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002190 ! cap-independent translational initiation
relationship: negatively_regulates GO:0002190 ! cap-independent translational initiation
created_by: bf
creation_date: 2014-11-27T19:52:28Z

[Term]
id: GO:1903679
name: positive regulation of cap-independent translational initiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cap-independent translational initiation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11959995]
synonym: "activation of cap-independent translational initiation" NARROW [GOC:TermGenie]
synonym: "up regulation of cap-independent translational initiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of cap-independent translational initiation" EXACT [GOC:TermGenie]
synonym: "upregulation of cap-independent translational initiation" EXACT [GOC:TermGenie]
is_a: GO:1903677 ! regulation of cap-independent translational initiation
is_a: GO:1904690 ! positive regulation of cytoplasmic translational initiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002190 ! cap-independent translational initiation
relationship: positively_regulates GO:0002190 ! cap-independent translational initiation
created_by: bf
creation_date: 2014-11-27T19:52:36Z

[Term]
id: GO:1903680
name: acinar cell of sebaceous gland differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of an acinar cell of sebaceous gland." [GO_REF:0000086, GOC:TermGenie, PMID:17018284, PMID:18334552, PMID:19944183]
synonym: "sebocyte differentiation" EXACT [CL:0002140]
is_a: GO:0001949 ! sebaceous gland cell differentiation
is_a: GO:0090425 ! acinar cell differentiation
created_by: cynthia.smith
creation_date: 2014-11-30T11:51:57Z

[Term]
id: GO:1903681
name: regulation of epithelial cell-cell adhesion involved in epithelium migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of epithelial cell-cell adhesion involved in epithelium migration." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18394891]
is_a: GO:0022407 ! regulation of cell-cell adhesion
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0090137 ! epithelial cell-cell adhesion involved in epithelium migration
relationship: regulates GO:0090137 ! epithelial cell-cell adhesion involved in epithelium migration
created_by: als
creation_date: 2014-12-01T13:25:05Z

[Term]
id: GO:1903682
name: negative regulation of epithelial cell-cell adhesion involved in epithelium migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell-cell adhesion involved in epithelium migration." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18394891]
synonym: "down regulation of epithelial cell-cell adhesion involved in epithelium migration" EXACT [GOC:TermGenie]
synonym: "down-regulation of epithelial cell-cell adhesion involved in epithelium migration" EXACT [GOC:TermGenie]
synonym: "downregulation of epithelial cell-cell adhesion involved in epithelium migration" EXACT [GOC:TermGenie]
synonym: "inhibition of epithelial cell-cell adhesion involved in epithelium migration" NARROW [GOC:TermGenie]
is_a: GO:0022408 ! negative regulation of cell-cell adhesion
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1903681 ! regulation of epithelial cell-cell adhesion involved in epithelium migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0090137 ! epithelial cell-cell adhesion involved in epithelium migration
relationship: negatively_regulates GO:0090137 ! epithelial cell-cell adhesion involved in epithelium migration
created_by: als
creation_date: 2014-12-01T13:25:14Z

[Term]
id: GO:1903683
name: positive regulation of epithelial cell-cell adhesion involved in epithelium migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of epithelial cell-cell adhesion involved in epithelium migration." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18394891]
synonym: "activation of epithelial cell-cell adhesion involved in epithelium migration" NARROW [GOC:TermGenie]
synonym: "up regulation of epithelial cell-cell adhesion involved in epithelium migration" EXACT [GOC:TermGenie]
synonym: "up-regulation of epithelial cell-cell adhesion involved in epithelium migration" EXACT [GOC:TermGenie]
synonym: "upregulation of epithelial cell-cell adhesion involved in epithelium migration" EXACT [GOC:TermGenie]
is_a: GO:0022409 ! positive regulation of cell-cell adhesion
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1903681 ! regulation of epithelial cell-cell adhesion involved in epithelium migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0090137 ! epithelial cell-cell adhesion involved in epithelium migration
relationship: positively_regulates GO:0090137 ! epithelial cell-cell adhesion involved in epithelium migration
created_by: als
creation_date: 2014-12-01T13:25:22Z

[Term]
id: GO:1903684
name: regulation of border follicle cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of border follicle cell migration." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18394891]
synonym: "regulation of border cell migration" BROAD [GOC:TermGenie]
is_a: GO:0010632 ! regulation of epithelial cell migration
is_a: GO:0030856 ! regulation of epithelial cell differentiation
is_a: GO:0043900 ! regulation of multi-organism process
is_a: GO:0060284 ! regulation of cell development
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007298 ! border follicle cell migration
relationship: regulates GO:0007298 ! border follicle cell migration
created_by: als
creation_date: 2014-12-01T13:35:39Z

[Term]
id: GO:1903687
name: negative regulation of border follicle cell migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of border follicle cell migration." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18394891]
synonym: "inhibition of border follicle cell migration" NARROW [GOC:TermGenie]
is_a: GO:0010633 ! negative regulation of epithelial cell migration
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0030857 ! negative regulation of epithelial cell differentiation
is_a: GO:0043901 ! negative regulation of multi-organism process
is_a: GO:1903684 ! regulation of border follicle cell migration
is_a: GO:2000242 ! negative regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007298 ! border follicle cell migration
relationship: negatively_regulates GO:0007298 ! border follicle cell migration
created_by: als
creation_date: 2014-12-01T13:41:05Z

[Term]
id: GO:1903688
name: positive regulation of border follicle cell migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of border follicle cell migration." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18394891]
synonym: "activation of border follicle cell migration" NARROW [GOC:TermGenie]
is_a: GO:0010634 ! positive regulation of epithelial cell migration
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0030858 ! positive regulation of epithelial cell differentiation
is_a: GO:0043902 ! positive regulation of multi-organism process
is_a: GO:1903684 ! regulation of border follicle cell migration
is_a: GO:2000243 ! positive regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007298 ! border follicle cell migration
relationship: positively_regulates GO:0007298 ! border follicle cell migration
created_by: als
creation_date: 2014-12-01T13:41:19Z

[Term]
id: GO:1903689
name: regulation of wound healing, spreading of epidermal cells
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of wound healing, spreading of epidermal cells." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18394891]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0030334 ! regulation of cell migration
is_a: GO:0061041 ! regulation of wound healing
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035313 ! wound healing, spreading of epidermal cells
relationship: regulates GO:0035313 ! wound healing, spreading of epidermal cells
created_by: als
creation_date: 2014-12-01T15:54:18Z

[Term]
id: GO:1903690
name: negative regulation of wound healing, spreading of epidermal cells
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of wound healing, spreading of epidermal cells." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18394891]
synonym: "down regulation of wound healing, spreading of epidermal cells" EXACT [GOC:TermGenie]
synonym: "down-regulation of wound healing, spreading of epidermal cells" EXACT [GOC:TermGenie]
synonym: "downregulation of wound healing, spreading of epidermal cells" EXACT [GOC:TermGenie]
synonym: "inhibition of wound healing, spreading of epidermal cells" NARROW [GOC:TermGenie]
is_a: GO:0030336 ! negative regulation of cell migration
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0061045 ! negative regulation of wound healing
is_a: GO:1903689 ! regulation of wound healing, spreading of epidermal cells
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035313 ! wound healing, spreading of epidermal cells
relationship: negatively_regulates GO:0035313 ! wound healing, spreading of epidermal cells
created_by: als
creation_date: 2014-12-01T15:54:27Z

[Term]
id: GO:1903691
name: positive regulation of wound healing, spreading of epidermal cells
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of wound healing, spreading of epidermal cells." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18394891]
synonym: "activation of wound healing, spreading of epidermal cells" NARROW [GOC:TermGenie]
synonym: "up regulation of wound healing, spreading of epidermal cells" EXACT [GOC:TermGenie]
synonym: "up-regulation of wound healing, spreading of epidermal cells" EXACT [GOC:TermGenie]
synonym: "upregulation of wound healing, spreading of epidermal cells" EXACT [GOC:TermGenie]
is_a: GO:0030335 ! positive regulation of cell migration
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0090303 ! positive regulation of wound healing
is_a: GO:1903689 ! regulation of wound healing, spreading of epidermal cells
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035313 ! wound healing, spreading of epidermal cells
relationship: positively_regulates GO:0035313 ! wound healing, spreading of epidermal cells
created_by: als
creation_date: 2014-12-01T15:54:35Z

[Term]
id: GO:1903692
name: methionine import into cell
namespace: biological_process
def: "The directed movement of methionine into a cell." [GO_REF:0000075, GOC:TermGenie, PMID:17556368]
is_a: GO:0044690 ! methionine import
created_by: mah
creation_date: 2014-12-02T10:53:28Z

[Term]
id: GO:1903693
name: regulation of mitotic G1 cell cycle arrest in response to nitrogen starvation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitotic G1 cell cycle arrest in response to nitrogen starvation." [GO_REF:0000058, GOC:TermGenie, PMID:15713656]
synonym: "regulation of G1 mitotic cell cycle arrest in response to nitrogen starvation" EXACT [GOC:TermGenie]
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0032107 ! regulation of response to nutrient levels
is_a: GO:0071156 ! regulation of cell cycle arrest
is_a: GO:0080135 ! regulation of cellular response to stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071851 ! mitotic G1 cell cycle arrest in response to nitrogen starvation
relationship: regulates GO:0071851 ! mitotic G1 cell cycle arrest in response to nitrogen starvation
created_by: al
creation_date: 2014-12-02T18:16:03Z

[Term]
id: GO:1903694
name: positive regulation of mitotic G1 cell cycle arrest in response to nitrogen starvation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitotic G1 cell cycle arrest in response to nitrogen starvation." [GO_REF:0000058, GOC:TermGenie, PMID:15713656]
synonym: "activation of G1 mitotic cell cycle arrest in response to nitrogen starvation" NARROW [GOC:TermGenie]
synonym: "activation of mitotic G1 cell cycle arrest in response to nitrogen starvation" NARROW [GOC:TermGenie]
synonym: "positive regulation of G1 mitotic cell cycle arrest in response to nitrogen starvation" EXACT [GOC:TermGenie]
synonym: "up regulation of G1 mitotic cell cycle arrest in response to nitrogen starvation" EXACT [GOC:TermGenie]
synonym: "up regulation of mitotic G1 cell cycle arrest in response to nitrogen starvation" EXACT [GOC:TermGenie]
synonym: "up-regulation of G1 mitotic cell cycle arrest in response to nitrogen starvation" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitotic G1 cell cycle arrest in response to nitrogen starvation" EXACT [GOC:TermGenie]
synonym: "upregulation of G1 mitotic cell cycle arrest in response to nitrogen starvation" EXACT [GOC:TermGenie]
synonym: "upregulation of mitotic G1 cell cycle arrest in response to nitrogen starvation" EXACT [GOC:TermGenie]
is_a: GO:0071158 ! positive regulation of cell cycle arrest
is_a: GO:1903693 ! regulation of mitotic G1 cell cycle arrest in response to nitrogen starvation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071851 ! mitotic G1 cell cycle arrest in response to nitrogen starvation
relationship: positively_regulates GO:0071851 ! mitotic G1 cell cycle arrest in response to nitrogen starvation
created_by: al
creation_date: 2014-12-02T18:16:16Z

[Term]
id: GO:1903695
name: MAPK cascade involved in ascospore formation
namespace: biological_process
def: "Any MAPK cascade that is involved in ascospore formation." [GO_REF:0000060, GOC:TermGenie, PMID:8443406]
synonym: "ERK/MAPK cascade involved in ascospore biosynthesis" NARROW [GOC:TermGenie]
synonym: "ERK/MAPK cascade involved in ascospore formation" NARROW [GOC:TermGenie]
synonym: "MAP kinase cascade involved in ascospore biosynthesis" EXACT [GOC:TermGenie]
synonym: "MAP kinase cascade involved in ascospore formation" EXACT [GOC:TermGenie]
synonym: "MAP kinase kinase kinase cascade involved in ascospore biosynthesis" EXACT [GOC:TermGenie]
synonym: "MAP kinase kinase kinase cascade involved in ascospore formation" EXACT [GOC:TermGenie]
synonym: "MAPK cascade involved in ascospore biosynthesis" EXACT [GOC:TermGenie]
synonym: "MAPK signal transduction involved in ascospore biosynthesis" EXACT [GOC:TermGenie]
synonym: "MAPK signal transduction involved in ascospore formation" EXACT [GOC:TermGenie]
synonym: "MAPK signaling involved in ascospore biosynthesis" RELATED [GOC:TermGenie]
synonym: "MAPK signaling involved in ascospore formation" RELATED [GOC:TermGenie]
synonym: "MAPK signalling involved in ascospore biosynthesis" RELATED [GOC:TermGenie]
synonym: "MAPK signalling involved in ascospore formation" RELATED [GOC:TermGenie]
synonym: "MAPKKK cascade during sporulation involved in ascospore biosynthesis" NARROW [GOC:TermGenie]
synonym: "MAPKKK cascade during sporulation involved in ascospore formation" NARROW [GOC:TermGenie]
synonym: "MAPKKK cascade involved in ascospore biosynthesis" EXACT [GOC:TermGenie]
synonym: "MAPKKK cascade involved in ascospore formation" EXACT [GOC:TermGenie]
synonym: "mitogen-activated protein kinase cascade involved in ascospore biosynthesis" EXACT [GOC:TermGenie]
synonym: "mitogen-activated protein kinase cascade involved in ascospore formation" EXACT [GOC:TermGenie]
is_a: GO:0000165 ! MAPK cascade
is_a: GO:1903046 ! meiotic cell cycle process
intersection_of: GO:0000165 ! MAPK cascade
intersection_of: part_of GO:0030437 ! ascospore formation
relationship: part_of GO:0030437 ! ascospore formation
created_by: al
creation_date: 2014-12-02T22:09:18Z

[Term]
id: GO:1903696
name: protein localization to horsetail-astral microtubule array
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a horsetail-astral microtubule array." [GO_REF:0000087, GOC:TermGenie, PMID:11907273]
synonym: "protein localisation in horsetail-astral microtubule array" EXACT [GOC:TermGenie]
synonym: "protein localisation to horsetail-astral microtubule array" EXACT [GOC:TermGenie]
synonym: "protein localization in horsetail-astral microtubule array" EXACT [GOC:TermGenie]
is_a: GO:0072699 ! protein localization to cortical microtubule cytoskeleton
created_by: mah
creation_date: 2014-12-03T10:58:18Z

[Term]
id: GO:1903697
name: negative regulation of microvillus assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of microvillus assembly." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22797597]
synonym: "down regulation of microvillus assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of microvillus biogenesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of microvillus assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of microvillus biogenesis" RELATED [GOC:TermGenie]
synonym: "downregulation of microvillus assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of microvillus biogenesis" RELATED [GOC:TermGenie]
synonym: "inhibition of microvillus assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of microvillus biogenesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of microvillus biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0031345 ! negative regulation of cell projection organization
is_a: GO:0032534 ! regulation of microvillus assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030033 ! microvillus assembly
relationship: negatively_regulates GO:0030033 ! microvillus assembly
created_by: als
creation_date: 2014-12-03T11:45:08Z

[Term]
id: GO:1903698
name: positive regulation of microvillus assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of microvillus assembly." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22797597]
synonym: "activation of microvillus assembly" NARROW [GOC:TermGenie]
synonym: "activation of microvillus biogenesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of microvillus biogenesis" RELATED [GOC:TermGenie]
synonym: "up regulation of microvillus assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of microvillus biogenesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of microvillus assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of microvillus biogenesis" RELATED [GOC:TermGenie]
synonym: "upregulation of microvillus assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of microvillus biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0031346 ! positive regulation of cell projection organization
is_a: GO:0032534 ! regulation of microvillus assembly
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030033 ! microvillus assembly
relationship: positively_regulates GO:0030033 ! microvillus assembly
created_by: als
creation_date: 2014-12-03T11:45:17Z

[Term]
id: GO:1903699
name: tarsal gland development
namespace: biological_process
def: "The process whose specific outcome is the progression of a tarsal gland over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, PMID:20664693]
synonym: "gland of Meibom development" EXACT [GOC:TermGenie]
synonym: "glandula tarsales development" EXACT [GOC:TermGenie]
synonym: "Meibomian gland development" EXACT [GOC:TermGenie]
synonym: "tarsoconjunctival gland development" RELATED [GOC:TermGenie]
is_a: GO:0048733 ! sebaceous gland development
created_by: cynthia.smith
creation_date: 2014-12-03T11:47:07Z

[Term]
id: GO:1903700
name: caecum development
namespace: biological_process
def: "The process whose specific outcome is the progression of a caecum over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, ISBN:0-683-40008-8]
synonym: "blind intestine development" RELATED [GOC:TermGenie]
synonym: "blindgut development" RELATED [GOC:TermGenie]
synonym: "caeca development" NARROW [GOC:TermGenie]
synonym: "ceca development" NARROW [GOC:TermGenie]
synonym: "cecum development" EXACT [GOC:TermGenie]
synonym: "intestinum caecum development" RELATED [GOC:TermGenie]
synonym: "intestinum crassum caecum development" EXACT [GOC:TermGenie]
synonym: "intestinum crassum cecum development" RELATED [GOC:TermGenie]
is_a: GO:0048856 ! anatomical structure development
created_by: cynthia.smith
creation_date: 2014-12-03T12:05:00Z

[Term]
id: GO:1903701
name: substantia propria of cornea development
namespace: biological_process
def: "The process whose specific outcome is the progression of a substantia propria of cornea over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, PMID:12556382]
synonym: "corneal stroma development" EXACT [GOC:TermGenie]
synonym: "stroma of cornea development" EXACT [GOC:TermGenie]
synonym: "substantia propria development" RELATED [GOC:TermGenie]
is_a: GO:0048856 ! anatomical structure development
created_by: cynthia.smith
creation_date: 2014-12-03T13:12:09Z

[Term]
id: GO:1903702
name: esophagus development
namespace: biological_process
def: "The process whose specific outcome is the progression of an esophagus over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, ISBN:0-683-40008-8]
synonym: "esophageal development" EXACT [MGI:csmith]
synonym: "gullet development" EXACT [GOC:TermGenie]
synonym: "oesophagus development" EXACT [GOC:TermGenie]
is_a: GO:0048513 ! animal organ development
created_by: cynthia.smith
creation_date: 2014-12-03T14:41:30Z

[Term]
id: GO:1903703
name: enterocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of an enterocyte." [GO_REF:0000086, GOC:TermGenie, http://en.wikipedia.org/wiki/List_of_intestinal_epithelial_differentiation_genes, PMID:16782882]
is_a: GO:0060575 ! intestinal epithelial cell differentiation
created_by: cynthia.smith
creation_date: 2014-12-03T15:08:51Z

[Term]
id: GO:1903704
name: negative regulation of production of siRNA involved in RNA interference
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of production of siRNA involved in RNA interference." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19701182]
synonym: "down regulation of production of guide RNAs involved in RNA interference" EXACT [GOC:TermGenie]
synonym: "down regulation of production of siRNA involved in RNA interference" EXACT [GOC:TermGenie]
synonym: "down regulation of RNA interference, production of guide RNAs" EXACT [GOC:TermGenie]
synonym: "down regulation of RNA interference, production of siRNA" EXACT [GOC:TermGenie]
synonym: "down-regulation of production of guide RNAs involved in RNA interference" EXACT [GOC:TermGenie]
synonym: "down-regulation of production of siRNA involved in RNA interference" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA interference, production of guide RNAs" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA interference, production of siRNA" EXACT [GOC:TermGenie]
synonym: "downregulation of production of guide RNAs involved in RNA interference" EXACT [GOC:TermGenie]
synonym: "downregulation of production of siRNA involved in RNA interference" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA interference, production of guide RNAs" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA interference, production of siRNA" EXACT [GOC:TermGenie]
synonym: "inhibition of production of guide RNAs involved in RNA interference" NARROW [GOC:TermGenie]
synonym: "inhibition of production of siRNA involved in RNA interference" NARROW [GOC:TermGenie]
synonym: "inhibition of RNA interference, production of guide RNAs" NARROW [GOC:TermGenie]
synonym: "inhibition of RNA interference, production of siRNA" NARROW [GOC:TermGenie]
synonym: "negative regulation of production of guide RNAs involved in RNA interference" EXACT [GOC:TermGenie]
synonym: "negative regulation of RNA interference, production of guide RNAs" EXACT [GOC:TermGenie]
synonym: "negative regulation of RNA interference, production of siRNA" EXACT [GOC:TermGenie]
is_a: GO:0010629 ! negative regulation of gene expression
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:0051253 ! negative regulation of RNA metabolic process
is_a: GO:0090065 ! regulation of production of siRNA involved in RNA interference
is_a: GO:1900369 ! negative regulation of RNA interference
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030422 ! production of siRNA involved in RNA interference
relationship: negatively_regulates GO:0030422 ! production of siRNA involved in RNA interference
created_by: nc
creation_date: 2014-12-03T15:13:22Z

[Term]
id: GO:1903705
name: positive regulation of production of siRNA involved in RNA interference
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of production of siRNA involved in RNA interference." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19701182]
synonym: "activation of production of guide RNAs involved in RNA interference" NARROW [GOC:TermGenie]
synonym: "activation of production of siRNA involved in RNA interference" NARROW [GOC:TermGenie]
synonym: "activation of RNA interference, production of guide RNAs" NARROW [GOC:TermGenie]
synonym: "activation of RNA interference, production of siRNA" NARROW [GOC:TermGenie]
synonym: "positive regulation of production of guide RNAs involved in RNA interference" EXACT [GOC:TermGenie]
synonym: "positive regulation of RNA interference, production of guide RNAs" EXACT [GOC:TermGenie]
synonym: "positive regulation of RNA interference, production of siRNA" EXACT [GOC:TermGenie]
synonym: "up regulation of production of guide RNAs involved in RNA interference" EXACT [GOC:TermGenie]
synonym: "up regulation of production of siRNA involved in RNA interference" EXACT [GOC:TermGenie]
synonym: "up regulation of RNA interference, production of guide RNAs" EXACT [GOC:TermGenie]
synonym: "up regulation of RNA interference, production of siRNA" EXACT [GOC:TermGenie]
synonym: "up-regulation of production of guide RNAs involved in RNA interference" EXACT [GOC:TermGenie]
synonym: "up-regulation of production of siRNA involved in RNA interference" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNA interference, production of guide RNAs" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNA interference, production of siRNA" EXACT [GOC:TermGenie]
synonym: "upregulation of production of guide RNAs involved in RNA interference" EXACT [GOC:TermGenie]
synonym: "upregulation of production of siRNA involved in RNA interference" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA interference, production of guide RNAs" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA interference, production of siRNA" EXACT [GOC:TermGenie]
is_a: GO:0010628 ! positive regulation of gene expression
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:0051254 ! positive regulation of RNA metabolic process
is_a: GO:0090065 ! regulation of production of siRNA involved in RNA interference
is_a: GO:1900370 ! positive regulation of RNA interference
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030422 ! production of siRNA involved in RNA interference
relationship: positively_regulates GO:0030422 ! production of siRNA involved in RNA interference
created_by: nc
creation_date: 2014-12-03T15:13:30Z

[Term]
id: GO:1903706
name: regulation of hemopoiesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hemopoiesis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761]
comment: An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype.
synonym: "regulation of blood cell biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of blood cell formation" EXACT [GOC:TermGenie]
synonym: "regulation of haemopoiesis" EXACT [GOC:TermGenie]
synonym: "regulation of hematopoiesis" EXACT [GOC:TermGenie]
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030097 ! hemopoiesis
relationship: regulates GO:0030097 ! hemopoiesis
created_by: pad
creation_date: 2014-12-04T15:34:13Z

[Term]
id: GO:1903707
name: negative regulation of hemopoiesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hemopoiesis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761]
comment: An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype.
synonym: "down regulation of blood cell biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of blood cell formation" EXACT [GOC:TermGenie]
synonym: "down regulation of haemopoiesis" EXACT [GOC:TermGenie]
synonym: "down regulation of hematopoiesis" EXACT [GOC:TermGenie]
synonym: "down regulation of hemopoiesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of blood cell biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of blood cell formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of haemopoiesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of hematopoiesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of hemopoiesis" EXACT [GOC:TermGenie]
synonym: "downregulation of blood cell biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of blood cell formation" EXACT [GOC:TermGenie]
synonym: "downregulation of haemopoiesis" EXACT [GOC:TermGenie]
synonym: "downregulation of hematopoiesis" EXACT [GOC:TermGenie]
synonym: "downregulation of hemopoiesis" EXACT [GOC:TermGenie]
synonym: "inhibition of blood cell biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of blood cell formation" NARROW [GOC:TermGenie]
synonym: "inhibition of haemopoiesis" NARROW [GOC:TermGenie]
synonym: "inhibition of hematopoiesis" NARROW [GOC:TermGenie]
synonym: "inhibition of hemopoiesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of blood cell biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of blood cell formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of haemopoiesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of hematopoiesis" EXACT [GOC:TermGenie]
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1903706 ! regulation of hemopoiesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030097 ! hemopoiesis
relationship: negatively_regulates GO:0030097 ! hemopoiesis
created_by: pad
creation_date: 2014-12-04T15:34:21Z

[Term]
id: GO:1903708
name: positive regulation of hemopoiesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hemopoiesis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761]
comment: An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype.
synonym: "activation of blood cell biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of blood cell formation" NARROW [GOC:TermGenie]
synonym: "activation of haemopoiesis" NARROW [GOC:TermGenie]
synonym: "activation of hematopoiesis" NARROW [GOC:TermGenie]
synonym: "activation of hemopoiesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of blood cell biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of blood cell formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of haemopoiesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of hematopoiesis" EXACT [GOC:TermGenie]
synonym: "up regulation of blood cell biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of blood cell formation" EXACT [GOC:TermGenie]
synonym: "up regulation of haemopoiesis" EXACT [GOC:TermGenie]
synonym: "up regulation of hematopoiesis" EXACT [GOC:TermGenie]
synonym: "up regulation of hemopoiesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of blood cell biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of blood cell formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of haemopoiesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of hematopoiesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of hemopoiesis" EXACT [GOC:TermGenie]
synonym: "upregulation of blood cell biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of blood cell formation" EXACT [GOC:TermGenie]
synonym: "upregulation of haemopoiesis" EXACT [GOC:TermGenie]
synonym: "upregulation of hematopoiesis" EXACT [GOC:TermGenie]
synonym: "upregulation of hemopoiesis" EXACT [GOC:TermGenie]
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1903706 ! regulation of hemopoiesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030097 ! hemopoiesis
relationship: positively_regulates GO:0030097 ! hemopoiesis
created_by: pad
creation_date: 2014-12-04T15:34:30Z

[Term]
id: GO:1903709
name: uterine gland development
namespace: biological_process
def: "The process whose specific outcome is the progression of an uterine gland over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, PMID:23619340]
synonym: "endometrial gland development" EXACT [GOC:TermGenie]
synonym: "endometrium gland development" EXACT [GOC:TermGenie]
synonym: "glandulae uterinae development" RELATED [GOC:TermGenie]
synonym: "glandular part of endometrium development" RELATED [GOC:TermGenie]
synonym: "set of uterine glands development" RELATED [GOC:TermGenie]
synonym: "uterine glands development" EXACT [GOC:TermGenie]
synonym: "uterine glands set development" EXACT [GOC:TermGenie]
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0048608 ! reproductive structure development
is_a: GO:0048732 ! gland development
created_by: cynthia.smith
creation_date: 2014-12-04T18:57:21Z

[Term]
id: GO:1903710
name: spermine transmembrane transport
namespace: biological_process
def: "The directed movement of spermine across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:15637075]
is_a: GO:0000296 ! spermine transport
is_a: GO:0072488 ! ammonium transmembrane transport
is_a: GO:1902047 ! polyamine transmembrane transport
created_by: vw
creation_date: 2014-12-06T08:11:32Z

[Term]
id: GO:1903711
name: spermidine transmembrane transport
namespace: biological_process
def: "The directed movement of spermidine across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:15637075]
is_a: GO:0015848 ! spermidine transport
is_a: GO:0072488 ! ammonium transmembrane transport
is_a: GO:1902047 ! polyamine transmembrane transport
created_by: vw
creation_date: 2014-12-06T08:12:44Z

[Term]
id: GO:1903712
name: cysteine transmembrane transport
namespace: biological_process
def: "The directed movement of cysteine across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:17435223]
is_a: GO:0003333 ! amino acid transmembrane transport
is_a: GO:0042883 ! cysteine transport
is_a: GO:0098655 ! cation transmembrane transport
created_by: vw
creation_date: 2014-12-06T08:15:06Z

[Term]
id: GO:1903713
name: asparagine transmembrane transport
namespace: biological_process
def: "The directed movement of asparagine across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:18503766]
is_a: GO:0003333 ! amino acid transmembrane transport
is_a: GO:0006867 ! asparagine transport
is_a: GO:0098655 ! cation transmembrane transport
created_by: vw
creation_date: 2014-12-06T08:17:55Z

[Term]
id: GO:1903714
name: isoleucine transmembrane transport
namespace: biological_process
def: "The directed movement of isoleucine across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:18503766]
is_a: GO:0003333 ! amino acid transmembrane transport
is_a: GO:0015818 ! isoleucine transport
is_a: GO:0098655 ! cation transmembrane transport
created_by: vw
creation_date: 2014-12-06T08:19:05Z

[Term]
id: GO:1903715
name: regulation of aerobic respiration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of aerobic respiration." [GO_REF:0000058, GOC:TermGenie, PMID:19266076]
is_a: GO:0043457 ! regulation of cellular respiration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009060 ! aerobic respiration
relationship: regulates GO:0009060 ! aerobic respiration
created_by: al
creation_date: 2014-12-08T00:40:37Z

[Term]
id: GO:1903716
name: guanine transmembrane transport
namespace: biological_process
def: "The directed movement of guanine across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:14998997]
is_a: GO:0015854 ! guanine transport
is_a: GO:1904823 ! purine nucleobase transmembrane transport
created_by: vw
creation_date: 2014-12-08T12:18:27Z

[Term]
id: GO:1903717
name: response to ammonia
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonia stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23509267]
is_a: GO:0010035 ! response to inorganic substance
is_a: GO:0060359 ! response to ammonium ion
created_by: ha
creation_date: 2014-12-08T14:55:44Z

[Term]
id: GO:1903718
name: cellular response to ammonia
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonia stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23509267]
is_a: GO:0071242 ! cellular response to ammonium ion
is_a: GO:1903717 ! response to ammonia
created_by: ha
creation_date: 2014-12-08T14:55:54Z

[Term]
id: GO:1903719
name: regulation of I-kappaB phosphorylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of I-kappaB phosphorylation." [GO_REF:0000058, GOC:TermGenie, PubMed:23675531]
synonym: "regulation of IkappaB phosphorylation" EXACT [GOC:TermGenie]
synonym: "regulation of IKB phosphorylation" EXACT [GOC:TermGenie]
synonym: "regulation of inhibitor of kappaB phosphorylation" EXACT [GOC:TermGenie]
synonym: "regulation of inhibitor of NF-kappaB phosphorylation" EXACT [GOC:TermGenie]
is_a: GO:0001932 ! regulation of protein phosphorylation
is_a: GO:0043122 ! regulation of I-kappaB kinase/NF-kappaB signaling
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007252 ! I-kappaB phosphorylation
relationship: regulates GO:0007252 ! I-kappaB phosphorylation
created_by: lb
creation_date: 2014-12-08T15:45:07Z

[Term]
id: GO:1903720
name: negative regulation of I-kappaB phosphorylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of I-kappaB phosphorylation." [GO_REF:0000058, GOC:TermGenie, PubMed:23675531]
synonym: "down regulation of I-kappaB phosphorylation" EXACT [GOC:TermGenie]
synonym: "down regulation of IkappaB phosphorylation" EXACT [GOC:TermGenie]
synonym: "down regulation of IKB phosphorylation" EXACT [GOC:TermGenie]
synonym: "down regulation of inhibitor of kappaB phosphorylation" EXACT [GOC:TermGenie]
synonym: "down regulation of inhibitor of NF-kappaB phosphorylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of I-kappaB phosphorylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of IkappaB phosphorylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of IKB phosphorylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of inhibitor of kappaB phosphorylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of inhibitor of NF-kappaB phosphorylation" EXACT [GOC:TermGenie]
synonym: "downregulation of I-kappaB phosphorylation" EXACT [GOC:TermGenie]
synonym: "downregulation of IkappaB phosphorylation" EXACT [GOC:TermGenie]
synonym: "downregulation of IKB phosphorylation" EXACT [GOC:TermGenie]
synonym: "downregulation of inhibitor of kappaB phosphorylation" EXACT [GOC:TermGenie]
synonym: "downregulation of inhibitor of NF-kappaB phosphorylation" EXACT [GOC:TermGenie]
synonym: "inhibition of I-kappaB phosphorylation" NARROW [GOC:TermGenie]
synonym: "inhibition of IkappaB phosphorylation" NARROW [GOC:TermGenie]
synonym: "inhibition of IKB phosphorylation" NARROW [GOC:TermGenie]
synonym: "inhibition of inhibitor of kappaB phosphorylation" NARROW [GOC:TermGenie]
synonym: "inhibition of inhibitor of NF-kappaB phosphorylation" NARROW [GOC:TermGenie]
synonym: "negative regulation of IkappaB phosphorylation" EXACT [GOC:TermGenie]
synonym: "negative regulation of IKB phosphorylation" EXACT [GOC:TermGenie]
synonym: "negative regulation of inhibitor of kappaB phosphorylation" EXACT [GOC:TermGenie]
synonym: "negative regulation of inhibitor of NF-kappaB phosphorylation" EXACT [GOC:TermGenie]
is_a: GO:0001933 ! negative regulation of protein phosphorylation
is_a: GO:0043124 ! negative regulation of I-kappaB kinase/NF-kappaB signaling
is_a: GO:1903719 ! regulation of I-kappaB phosphorylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007252 ! I-kappaB phosphorylation
relationship: negatively_regulates GO:0007252 ! I-kappaB phosphorylation
created_by: lb
creation_date: 2014-12-08T15:45:16Z

[Term]
id: GO:1903721
name: positive regulation of I-kappaB phosphorylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of I-kappaB phosphorylation." [GO_REF:0000058, GOC:TermGenie, PubMed:23675531]
synonym: "activation of I-kappaB phosphorylation" NARROW [GOC:TermGenie]
synonym: "activation of IkappaB phosphorylation" NARROW [GOC:TermGenie]
synonym: "activation of IKB phosphorylation" NARROW [GOC:TermGenie]
synonym: "activation of inhibitor of kappaB phosphorylation" NARROW [GOC:TermGenie]
synonym: "activation of inhibitor of NF-kappaB phosphorylation" NARROW [GOC:TermGenie]
synonym: "positive regulation of IkappaB phosphorylation" EXACT [GOC:TermGenie]
synonym: "positive regulation of IKB phosphorylation" EXACT [GOC:TermGenie]
synonym: "positive regulation of inhibitor of kappaB phosphorylation" EXACT [GOC:TermGenie]
synonym: "positive regulation of inhibitor of NF-kappaB phosphorylation" EXACT [GOC:TermGenie]
synonym: "up regulation of I-kappaB phosphorylation" EXACT [GOC:TermGenie]
synonym: "up regulation of IkappaB phosphorylation" EXACT [GOC:TermGenie]
synonym: "up regulation of IKB phosphorylation" EXACT [GOC:TermGenie]
synonym: "up regulation of inhibitor of kappaB phosphorylation" EXACT [GOC:TermGenie]
synonym: "up regulation of inhibitor of NF-kappaB phosphorylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of I-kappaB phosphorylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of IkappaB phosphorylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of IKB phosphorylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of inhibitor of kappaB phosphorylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of inhibitor of NF-kappaB phosphorylation" EXACT [GOC:TermGenie]
synonym: "upregulation of I-kappaB phosphorylation" EXACT [GOC:TermGenie]
synonym: "upregulation of IkappaB phosphorylation" EXACT [GOC:TermGenie]
synonym: "upregulation of IKB phosphorylation" EXACT [GOC:TermGenie]
synonym: "upregulation of inhibitor of kappaB phosphorylation" EXACT [GOC:TermGenie]
synonym: "upregulation of inhibitor of NF-kappaB phosphorylation" EXACT [GOC:TermGenie]
is_a: GO:0001934 ! positive regulation of protein phosphorylation
is_a: GO:0043123 ! positive regulation of I-kappaB kinase/NF-kappaB signaling
is_a: GO:1903719 ! regulation of I-kappaB phosphorylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007252 ! I-kappaB phosphorylation
relationship: positively_regulates GO:0007252 ! I-kappaB phosphorylation
created_by: lb
creation_date: 2014-12-08T15:45:25Z

[Term]
id: GO:1903722
name: regulation of centriole elongation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of centriole elongation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:20616062]
is_a: GO:0046599 ! regulation of centriole replication
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061511 ! centriole elongation
relationship: regulates GO:0061511 ! centriole elongation
created_by: als
creation_date: 2014-12-09T16:36:02Z

[Term]
id: GO:1903723
name: negative regulation of centriole elongation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of centriole elongation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:20616062]
synonym: "down regulation of centriole elongation" EXACT [GOC:TermGenie]
synonym: "down-regulation of centriole elongation" EXACT [GOC:TermGenie]
synonym: "downregulation of centriole elongation" EXACT [GOC:TermGenie]
synonym: "inhibition of centriole elongation" NARROW [GOC:TermGenie]
is_a: GO:0046600 ! negative regulation of centriole replication
is_a: GO:1903722 ! regulation of centriole elongation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061511 ! centriole elongation
relationship: negatively_regulates GO:0061511 ! centriole elongation
created_by: als
creation_date: 2014-12-09T16:36:12Z

[Term]
id: GO:1903724
name: positive regulation of centriole elongation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of centriole elongation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:20616062]
synonym: "activation of centriole elongation" NARROW [GOC:TermGenie]
synonym: "up regulation of centriole elongation" EXACT [GOC:TermGenie]
synonym: "up-regulation of centriole elongation" EXACT [GOC:TermGenie]
synonym: "upregulation of centriole elongation" EXACT [GOC:TermGenie]
is_a: GO:0046601 ! positive regulation of centriole replication
is_a: GO:1903722 ! regulation of centriole elongation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061511 ! centriole elongation
relationship: positively_regulates GO:0061511 ! centriole elongation
created_by: als
creation_date: 2014-12-09T16:36:20Z

[Term]
id: GO:1903725
name: regulation of phospholipid metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phospholipid metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:10657240]
synonym: "regulation of phospholipid metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019216 ! regulation of lipid metabolic process
is_a: GO:0019220 ! regulation of phosphate metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006644 ! phospholipid metabolic process
relationship: regulates GO:0006644 ! phospholipid metabolic process
created_by: sl
creation_date: 2014-12-09T20:49:27Z

[Term]
id: GO:1903726
name: negative regulation of phospholipid metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of phospholipid metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:10657240]
synonym: "down regulation of phospholipid metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of phospholipid metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of phospholipid metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of phospholipid metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of phospholipid metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of phospholipid metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of phospholipid metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of phospholipid metabolism" NARROW [GOC:TermGenie]
synonym: "negative regulation of phospholipid metabolism" EXACT [GOC:TermGenie]
is_a: GO:0045833 ! negative regulation of lipid metabolic process
is_a: GO:0045936 ! negative regulation of phosphate metabolic process
is_a: GO:1903725 ! regulation of phospholipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006644 ! phospholipid metabolic process
relationship: negatively_regulates GO:0006644 ! phospholipid metabolic process
created_by: sl
creation_date: 2014-12-09T20:49:35Z

[Term]
id: GO:1903727
name: positive regulation of phospholipid metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phospholipid metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:10657240]
synonym: "activation of phospholipid metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of phospholipid metabolism" NARROW [GOC:TermGenie]
synonym: "positive regulation of phospholipid metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of phospholipid metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of phospholipid metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of phospholipid metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of phospholipid metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of phospholipid metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of phospholipid metabolism" EXACT [GOC:TermGenie]
is_a: GO:0045834 ! positive regulation of lipid metabolic process
is_a: GO:0045937 ! positive regulation of phosphate metabolic process
is_a: GO:1903725 ! regulation of phospholipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006644 ! phospholipid metabolic process
relationship: positively_regulates GO:0006644 ! phospholipid metabolic process
created_by: sl
creation_date: 2014-12-09T20:49:44Z

[Term]
id: GO:1903728
name: luteal cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a luteal cell. Large luteal cells develop from granulosa cells. Small luteal cells develop from theca cells." [GO_REF:0000086, GOC:TermGenie, MP:0001133]
synonym: "lutein cell differentiation" EXACT [CL:0000175]
is_a: GO:0030154 ! cell differentiation
created_by: cjm
creation_date: 2014-12-10T01:36:43Z

[Term]
id: GO:1903729
name: regulation of plasma membrane organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of plasma membrane organization." [GO_REF:0000058, GOC:TermGenie, PMID:24514900]
synonym: "regulation of plasma membrane organisation" EXACT [GOC:TermGenie]
synonym: "regulation of plasma membrane organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007009 ! plasma membrane organization
relationship: regulates GO:0007009 ! plasma membrane organization
created_by: al
creation_date: 2014-12-10T18:59:44Z

[Term]
id: GO:1903730
name: regulation of phosphatidate phosphatase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phosphatidate phosphatase activity." [GO_REF:0000059, GOC:TermGenie, PMID:22334681, PMID:24876385, PMID:25359770]
comment: Any process that modulates the frequency, rate or extent of phosphatidate phosphatase activity
synonym: "regulation of 3-sn-phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "regulation of acid phosphatidyl phosphatase activity" EXACT [GOC:TermGenie]
synonym: "regulation of phosphatic acid phosphatase activity" EXACT [GOC:TermGenie]
synonym: "regulation of phosphatic acid phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "regulation of phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "regulation of phosphatidic acid phosphatase activity" EXACT [GOC:TermGenie]
is_a: GO:0010921 ! regulation of phosphatase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008195 ! phosphatidate phosphatase activity
relationship: part_of GO:0010866 ! regulation of triglyceride biosynthetic process
relationship: part_of GO:0071071 ! regulation of phospholipid biosynthetic process
relationship: regulates GO:0008195 ! phosphatidate phosphatase activity
created_by: rn
creation_date: 2014-12-11T21:29:55Z

[Term]
id: GO:1903740
name: positive regulation of phosphatidate phosphatase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phosphatidate phosphatase activity." [GO_REF:0000059, GOC:rn, GOC:TermGenie, PMID:25359770]
synonym: "activation of 3-sn-phosphatidate phosphohydrolase activity" NARROW [GOC:TermGenie]
synonym: "activation of acid phosphatidyl phosphatase activity" NARROW [GOC:TermGenie]
synonym: "activation of phosphatic acid phosphatase activity" NARROW [GOC:TermGenie]
synonym: "activation of phosphatic acid phosphohydrolase activity" NARROW [GOC:TermGenie]
synonym: "activation of phosphatidate phosphatase activity" NARROW [GOC:TermGenie]
synonym: "activation of phosphatidate phosphohydrolase activity" NARROW [GOC:TermGenie]
synonym: "activation of phosphatidic acid phosphatase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of 3-sn-phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of acid phosphatidyl phosphatase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphatic acid phosphatase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphatic acid phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphatidic acid phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of 3-sn-phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of acid phosphatidyl phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphatic acid phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphatic acid phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphatidate phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphatidic acid phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of 3-sn-phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of acid phosphatidyl phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphatic acid phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphatic acid phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphatidate phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphatidic acid phosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of 3-sn-phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of acid phosphatidyl phosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphatic acid phosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphatic acid phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphatidate phosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphatidic acid phosphatase activity" EXACT [GOC:TermGenie]
is_a: GO:0010922 ! positive regulation of phosphatase activity
is_a: GO:1903730 ! regulation of phosphatidate phosphatase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008195 ! phosphatidate phosphatase activity
relationship: part_of GO:0010867 ! positive regulation of triglyceride biosynthetic process
relationship: part_of GO:0071073 ! positive regulation of phospholipid biosynthetic process
relationship: positively_regulates GO:0008195 ! phosphatidate phosphatase activity
created_by: tb
creation_date: 2014-12-11T23:37:44Z

[Term]
id: GO:1903741
name: negative regulation of phosphatidate phosphatase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidate phosphatase activity." [GO_REF:0000059, GOC:rn, GOC:TermGenie, PMID:22334681]
synonym: "down regulation of 3-sn-phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of acid phosphatidyl phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphatic acid phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphatic acid phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphatidate phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphatidic acid phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of 3-sn-phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of acid phosphatidyl phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphatic acid phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphatic acid phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphatidate phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphatidic acid phosphatase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of 3-sn-phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of acid phosphatidyl phosphatase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphatic acid phosphatase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphatic acid phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphatidate phosphatase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphatidic acid phosphatase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of 3-sn-phosphatidate phosphohydrolase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of acid phosphatidyl phosphatase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of phosphatic acid phosphatase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of phosphatic acid phosphohydrolase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of phosphatidate phosphatase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of phosphatidate phosphohydrolase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of phosphatidic acid phosphatase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of 3-sn-phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of acid phosphatidyl phosphatase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphatic acid phosphatase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphatic acid phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphatidic acid phosphatase activity" EXACT [GOC:TermGenie]
is_a: GO:0010923 ! negative regulation of phosphatase activity
is_a: GO:1903730 ! regulation of phosphatidate phosphatase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008195 ! phosphatidate phosphatase activity
relationship: negatively_regulates GO:0008195 ! phosphatidate phosphatase activity
relationship: part_of GO:0010868 ! negative regulation of triglyceride biosynthetic process
relationship: part_of GO:0071072 ! negative regulation of phospholipid biosynthetic process
created_by: tb
creation_date: 2014-12-11T23:37:54Z

[Term]
id: GO:1903742
name: regulation of anterograde synaptic vesicle transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of anterograde synaptic vesicle transport." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, pmid:25329901]
is_a: GO:1901608 ! regulation of vesicle transport along microtubule
is_a: GO:1902803 ! regulation of synaptic vesicle transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048490 ! anterograde synaptic vesicle transport
relationship: regulates GO:0048490 ! anterograde synaptic vesicle transport
created_by: kmv
creation_date: 2014-12-12T16:28:27Z

[Term]
id: GO:1903743
name: negative regulation of anterograde synaptic vesicle transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of anterograde synaptic vesicle transport." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, pmid:25329901]
synonym: "down regulation of anterograde synaptic vesicle transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of anterograde synaptic vesicle transport" EXACT [GOC:TermGenie]
synonym: "downregulation of anterograde synaptic vesicle transport" EXACT [GOC:TermGenie]
synonym: "inhibition of anterograde synaptic vesicle transport" NARROW [GOC:TermGenie]
is_a: GO:1901609 ! negative regulation of vesicle transport along microtubule
is_a: GO:1902804 ! negative regulation of synaptic vesicle transport
is_a: GO:1903742 ! regulation of anterograde synaptic vesicle transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048490 ! anterograde synaptic vesicle transport
relationship: negatively_regulates GO:0048490 ! anterograde synaptic vesicle transport
created_by: kmv
creation_date: 2014-12-12T16:28:37Z

[Term]
id: GO:1903744
name: positive regulation of anterograde synaptic vesicle transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of anterograde synaptic vesicle transport." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, pmid:25329901]
synonym: "activation of anterograde synaptic vesicle transport" NARROW [GOC:TermGenie]
synonym: "up regulation of anterograde synaptic vesicle transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of anterograde synaptic vesicle transport" EXACT [GOC:TermGenie]
synonym: "upregulation of anterograde synaptic vesicle transport" EXACT [GOC:TermGenie]
is_a: GO:1901610 ! positive regulation of vesicle transport along microtubule
is_a: GO:1902805 ! positive regulation of synaptic vesicle transport
is_a: GO:1903742 ! regulation of anterograde synaptic vesicle transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048490 ! anterograde synaptic vesicle transport
relationship: positively_regulates GO:0048490 ! anterograde synaptic vesicle transport
created_by: kmv
creation_date: 2014-12-12T16:28:46Z

[Term]
id: GO:1903745
name: negative regulation of pharyngeal pumping
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of pharyngeal pumping." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, pmid:25329901]
synonym: "down regulation of pharyngeal pumping" EXACT [GOC:TermGenie]
synonym: "down regulation of pumping behavior" RELATED [GOC:TermGenie]
synonym: "down-regulation of pharyngeal pumping" EXACT [GOC:TermGenie]
synonym: "down-regulation of pumping behavior" RELATED [GOC:TermGenie]
synonym: "downregulation of pharyngeal pumping" EXACT [GOC:TermGenie]
synonym: "downregulation of pumping behavior" RELATED [GOC:TermGenie]
synonym: "inhibition of pharyngeal pumping" NARROW [GOC:TermGenie]
synonym: "inhibition of pumping behavior" RELATED [GOC:TermGenie]
synonym: "negative regulation of pumping behavior" RELATED [GOC:TermGenie]
is_a: GO:0043051 ! regulation of pharyngeal pumping
is_a: GO:1903999 ! negative regulation of eating behavior
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043050 ! pharyngeal pumping
relationship: negatively_regulates GO:0043050 ! pharyngeal pumping
created_by: kmv
creation_date: 2014-12-12T17:10:59Z

[Term]
id: GO:1903746
name: positive regulation of pharyngeal pumping
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pharyngeal pumping." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, pmid:25329901]
synonym: "activation of pharyngeal pumping" NARROW [GOC:TermGenie]
synonym: "activation of pumping behavior" RELATED [GOC:TermGenie]
synonym: "positive regulation of pumping behavior" RELATED [GOC:TermGenie]
synonym: "up regulation of pharyngeal pumping" EXACT [GOC:TermGenie]
synonym: "up regulation of pumping behavior" RELATED [GOC:TermGenie]
synonym: "up-regulation of pharyngeal pumping" EXACT [GOC:TermGenie]
synonym: "up-regulation of pumping behavior" RELATED [GOC:TermGenie]
synonym: "upregulation of pharyngeal pumping" EXACT [GOC:TermGenie]
synonym: "upregulation of pumping behavior" RELATED [GOC:TermGenie]
is_a: GO:0043051 ! regulation of pharyngeal pumping
is_a: GO:1904000 ! positive regulation of eating behavior
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043050 ! pharyngeal pumping
relationship: positively_regulates GO:0043050 ! pharyngeal pumping
created_by: kmv
creation_date: 2014-12-12T17:11:09Z

[Term]
id: GO:1903747
name: regulation of establishment of protein localization to mitochondrion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of establishment of protein localization to mitochondrion." [GO_REF:0000058, GOC:TermGenie, PMID:16857185]
synonym: "regulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie]
synonym: "regulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie]
is_a: GO:0070201 ! regulation of establishment of protein localization
is_a: GO:1903827 ! regulation of cellular protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072655 ! establishment of protein localization to mitochondrion
relationship: regulates GO:0072655 ! establishment of protein localization to mitochondrion
created_by: krc
creation_date: 2014-12-12T22:18:09Z

[Term]
id: GO:1903748
name: negative regulation of establishment of protein localization to mitochondrion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization to mitochondrion." [GO_REF:0000058, GOC:TermGenie, PMID:16857185]
synonym: "down regulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie]
synonym: "down regulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie]
synonym: "down regulation of establishment of protein localization to mitochondrion" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of protein localization to mitochondrion" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of protein localization to mitochondrion" EXACT [GOC:TermGenie]
synonym: "inhibition of establishment of protein localisation to mitochondrion" NARROW [GOC:TermGenie]
synonym: "inhibition of establishment of protein localization in mitochondrion" NARROW [GOC:TermGenie]
synonym: "inhibition of establishment of protein localization to mitochondrion" NARROW [GOC:TermGenie]
synonym: "negative regulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie]
synonym: "negative regulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie]
is_a: GO:1903747 ! regulation of establishment of protein localization to mitochondrion
is_a: GO:1903828 ! negative regulation of cellular protein localization
is_a: GO:1904950 ! negative regulation of establishment of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072655 ! establishment of protein localization to mitochondrion
relationship: negatively_regulates GO:0072655 ! establishment of protein localization to mitochondrion
created_by: krc
creation_date: 2014-12-12T22:18:18Z

[Term]
id: GO:1903749
name: positive regulation of establishment of protein localization to mitochondrion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment of protein localization to mitochondrion." [GO_REF:0000058, GOC:TermGenie, PMID:16857185]
synonym: "activation of establishment of protein localisation to mitochondrion" NARROW [GOC:TermGenie]
synonym: "activation of establishment of protein localization in mitochondrion" NARROW [GOC:TermGenie]
synonym: "activation of establishment of protein localization to mitochondrion" NARROW [GOC:TermGenie]
synonym: "positive regulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie]
synonym: "positive regulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of protein localization to mitochondrion" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of protein localization to mitochondrion" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of protein localization to mitochondrion" EXACT [GOC:TermGenie]
is_a: GO:1903747 ! regulation of establishment of protein localization to mitochondrion
is_a: GO:1903829 ! positive regulation of cellular protein localization
is_a: GO:1904951 ! positive regulation of establishment of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072655 ! establishment of protein localization to mitochondrion
relationship: positively_regulates GO:0072655 ! establishment of protein localization to mitochondrion
created_by: krc
creation_date: 2014-12-12T22:18:26Z

[Term]
id: GO:1903750
name: regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to hydrogen peroxide." [GO_REF:0000058, GOC:TermGenie, PMID:18681888]
synonym: "regulation of H2O2-induced intrinsic apoptotic signaling pathway" RELATED [GOC:TermGenie]
synonym: "regulation of hydrogen peroxide-induced apoptosis" BROAD [GOC:TermGenie]
synonym: "regulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "regulation of intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie]
is_a: GO:1901298 ! regulation of hydrogen peroxide-mediated programmed cell death
is_a: GO:1902175 ! regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0036481 ! intrinsic apoptotic signaling pathway in response to hydrogen peroxide
relationship: regulates GO:0036481 ! intrinsic apoptotic signaling pathway in response to hydrogen peroxide
created_by: krc
creation_date: 2014-12-12T23:04:28Z

[Term]
id: GO:1903751
name: negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to hydrogen peroxide." [GO_REF:0000058, GOC:TermGenie, PMID:18681888]
synonym: "down regulation of H2O2-induced intrinsic apoptotic signaling pathway" RELATED [GOC:TermGenie]
synonym: "down regulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie]
synonym: "down regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide" EXACT [GOC:TermGenie]
synonym: "down-regulation of H2O2-induced intrinsic apoptotic signaling pathway" RELATED [GOC:TermGenie]
synonym: "down-regulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie]
synonym: "down-regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide" EXACT [GOC:TermGenie]
synonym: "downregulation of H2O2-induced intrinsic apoptotic signaling pathway" RELATED [GOC:TermGenie]
synonym: "downregulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie]
synonym: "downregulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide" EXACT [GOC:TermGenie]
synonym: "inhibition of H2O2-induced intrinsic apoptotic signaling pathway" RELATED [GOC:TermGenie]
synonym: "inhibition of hydrogen peroxide-induced intrinsic apoptotic signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of intrinsic apoptotic signaling pathway in response to H2O2" NARROW [GOC:TermGenie]
synonym: "inhibition of intrinsic apoptotic signaling pathway in response to hydrogen peroxide" NARROW [GOC:TermGenie]
synonym: "negative regulation of H2O2-induced intrinsic apoptotic signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie]
is_a: GO:1901299 ! negative regulation of hydrogen peroxide-mediated programmed cell death
is_a: GO:1902176 ! negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
is_a: GO:1903750 ! regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0036481 ! intrinsic apoptotic signaling pathway in response to hydrogen peroxide
relationship: negatively_regulates GO:0036481 ! intrinsic apoptotic signaling pathway in response to hydrogen peroxide
created_by: krc
creation_date: 2014-12-12T23:04:37Z

[Term]
id: GO:1903752
name: positive regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to hydrogen peroxide." [GO_REF:0000058, GOC:TermGenie, PMID:18681888]
synonym: "activation of H2O2-induced intrinsic apoptotic signaling pathway" RELATED [GOC:TermGenie]
synonym: "activation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of intrinsic apoptotic signaling pathway in response to H2O2" NARROW [GOC:TermGenie]
synonym: "activation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide" NARROW [GOC:TermGenie]
synonym: "positive regulation of H2O2-induced intrinsic apoptotic signaling pathway" RELATED [GOC:TermGenie]
synonym: "positive regulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie]
synonym: "up regulation of H2O2-induced intrinsic apoptotic signaling pathway" RELATED [GOC:TermGenie]
synonym: "up regulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie]
synonym: "up regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide" EXACT [GOC:TermGenie]
synonym: "up-regulation of H2O2-induced intrinsic apoptotic signaling pathway" RELATED [GOC:TermGenie]
synonym: "up-regulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie]
synonym: "up-regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide" EXACT [GOC:TermGenie]
synonym: "upregulation of H2O2-induced intrinsic apoptotic signaling pathway" RELATED [GOC:TermGenie]
synonym: "upregulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie]
synonym: "upregulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide" EXACT [GOC:TermGenie]
is_a: GO:1901300 ! positive regulation of hydrogen peroxide-mediated programmed cell death
is_a: GO:1902177 ! positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
is_a: GO:1903750 ! regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0036481 ! intrinsic apoptotic signaling pathway in response to hydrogen peroxide
relationship: positively_regulates GO:0036481 ! intrinsic apoptotic signaling pathway in response to hydrogen peroxide
created_by: krc
creation_date: 2014-12-12T23:04:46Z

[Term]
id: GO:1903753
name: negative regulation of p38MAPK cascade
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of p38MAPK cascade." [GO_REF:0000058, GOC:TermGenie, PMID:18681888]
synonym: "down regulation of p38 cascade" EXACT [GOC:TermGenie]
synonym: "down regulation of p38 MAPK cascade" EXACT [GOC:TermGenie]
synonym: "down regulation of p38MAPK cascade" EXACT [GOC:TermGenie]
synonym: "down-regulation of p38 cascade" EXACT [GOC:TermGenie]
synonym: "down-regulation of p38 MAPK cascade" EXACT [GOC:TermGenie]
synonym: "down-regulation of p38MAPK cascade" EXACT [GOC:TermGenie]
synonym: "downregulation of p38 cascade" EXACT [GOC:TermGenie]
synonym: "downregulation of p38 MAPK cascade" EXACT [GOC:TermGenie]
synonym: "downregulation of p38MAPK cascade" EXACT [GOC:TermGenie]
synonym: "inhibition of p38 cascade" NARROW [GOC:TermGenie]
synonym: "inhibition of p38 MAPK cascade" NARROW [GOC:TermGenie]
synonym: "inhibition of p38MAPK cascade" NARROW [GOC:TermGenie]
synonym: "negative regulation of p38 cascade" EXACT [GOC:TermGenie]
synonym: "negative regulation of p38 MAPK cascade" EXACT [GOC:TermGenie]
is_a: GO:0032873 ! negative regulation of stress-activated MAPK cascade
is_a: GO:1900744 ! regulation of p38MAPK cascade
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0038066 ! p38MAPK cascade
relationship: negatively_regulates GO:0038066 ! p38MAPK cascade
created_by: krc
creation_date: 2014-12-12T23:09:26Z

[Term]
id: GO:1903754
name: cortical microtubule plus-end
namespace: cellular_component
def: "The plus-end of a cortical microtubule." [GO_REF:0000064, GOC:TermGenie, GOC:vw]
synonym: "cortical microtubule plus end" EXACT []
is_a: GO:0044448 ! cell cortex part
is_a: GO:1904511 ! cytoplasmic microtubule plus-end
intersection_of: GO:0035371 ! microtubule plus-end
intersection_of: part_of GO:0055028 ! cortical microtubule
relationship: part_of GO:0055028 ! cortical microtubule
created_by: jl
creation_date: 2014-12-16T15:41:38Z

[Term]
id: GO:1903755
name: positive regulation of SUMO transferase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of SUMO transferase activity." [GO_REF:0000059, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:19955185]
synonym: "activation of SMT3 conjugating enzyme" RELATED [GOC:TermGenie]
synonym: "activation of SUMO conjugating enzyme activity" RELATED [GOC:TermGenie]
synonym: "activation of SUMO transferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of SMT3 conjugating enzyme" RELATED [GOC:TermGenie]
synonym: "positive regulation of SUMO conjugating enzyme activity" RELATED [GOC:TermGenie]
synonym: "up regulation of SMT3 conjugating enzyme" RELATED [GOC:TermGenie]
synonym: "up regulation of SUMO conjugating enzyme activity" RELATED [GOC:TermGenie]
synonym: "up regulation of SUMO transferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of SMT3 conjugating enzyme" RELATED [GOC:TermGenie]
synonym: "up-regulation of SUMO conjugating enzyme activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of SUMO transferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of SMT3 conjugating enzyme" RELATED [GOC:TermGenie]
synonym: "upregulation of SUMO conjugating enzyme activity" RELATED [GOC:TermGenie]
synonym: "upregulation of SUMO transferase activity" EXACT [GOC:TermGenie]
is_a: GO:0051347 ! positive regulation of transferase activity
is_a: GO:1903182 ! regulation of SUMO transferase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0019789 ! SUMO transferase activity
relationship: positively_regulates GO:0019789 ! SUMO transferase activity
created_by: rl
creation_date: 2014-12-18T13:05:59Z

[Term]
id: GO:1903756
name: regulation of transcription from RNA polymerase II promoter by histone modification
namespace: biological_process
def: "A histone modification that results in regulation of transcription from RNA polymerase II promoter." [GO_REF:0000063, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21102443]
synonym: "regulation of gene-specific transcription from RNA polymerase II promoter by histone modification" RELATED [GOC:TermGenie]
synonym: "regulation of global transcription from Pol II promoter by histone modification" RELATED [GOC:TermGenie]
synonym: "regulation of transcription from Pol II promoter by histone modification" EXACT [GOC:TermGenie]
synonym: "regulation of transcription from RNA polymerase II promoter, global by histone modification" RELATED [GOC:TermGenie]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0016570 ! histone modification
intersection_of: GO:0016570 ! histone modification
intersection_of: regulates GO:0006366 ! transcription from RNA polymerase II promoter
relationship: regulates GO:0006366 ! transcription from RNA polymerase II promoter
created_by: rl
creation_date: 2014-12-18T14:56:16Z

[Term]
id: GO:1903757
name: positive regulation of transcription from RNA polymerase II promoter by histone modification
namespace: biological_process
def: "A histone modification that results in positive regulation of transcription from RNA polymerase II promoter." [GO_REF:0000063, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21102443]
synonym: "activation of global transcription from RNA polymerase II promoter by histone modification" RELATED [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase II promoter by histone modification" EXACT [GOC:TermGenie]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter by histone modification" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription from Pol II promoter by histone modification" RELATED [GOC:TermGenie]
synonym: "positive regulation of transcription from Pol II promoter by histone modification" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription from RNA polymerase II promoter, global by histone modification" RELATED [GOC:TermGenie]
synonym: "stimulation of global transcription from RNA polymerase II promoter by histone modification" NARROW [GOC:TermGenie]
synonym: "stimulation of transcription from RNA polymerase II promoter by histone modification" EXACT [GOC:TermGenie]
synonym: "up regulation of global transcription from RNA polymerase II promoter by histone modification" RELATED [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase II promoter by histone modification" EXACT [GOC:TermGenie]
synonym: "up-regulation of global transcription from RNA polymerase II promoter by histone modification" RELATED [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase II promoter by histone modification" EXACT [GOC:TermGenie]
synonym: "upregulation of global transcription from RNA polymerase II promoter by histone modification" RELATED [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase II promoter by histone modification" EXACT [GOC:TermGenie]
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
is_a: GO:1903756 ! regulation of transcription from RNA polymerase II promoter by histone modification
intersection_of: GO:0016570 ! histone modification
intersection_of: positively_regulates GO:0006366 ! transcription from RNA polymerase II promoter
relationship: positively_regulates GO:0006366 ! transcription from RNA polymerase II promoter
created_by: rl
creation_date: 2014-12-18T15:06:07Z

[Term]
id: GO:1903758
name: negative regulation of transcription from RNA polymerase II promoter by histone modification
namespace: biological_process
def: "A histone modification that results in negative regulation of transcription from RNA polymerase II promoter." [GO_REF:0000063, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21102443]
synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter by histone modification" RELATED [GOC:TermGenie]
synonym: "negative regulation of global transcription from Pol II promoter by histone modification" RELATED [GOC:TermGenie]
synonym: "negative regulation of transcription from Pol II promoter by histone modification" EXACT [GOC:TermGenie]
synonym: "negative regulation of transcription from RNA polymerase II promoter, global by histone modification" RELATED [GOC:TermGenie]
is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
is_a: GO:1903756 ! regulation of transcription from RNA polymerase II promoter by histone modification
intersection_of: GO:0016570 ! histone modification
intersection_of: negatively_regulates GO:0006366 ! transcription from RNA polymerase II promoter
relationship: negatively_regulates GO:0006366 ! transcription from RNA polymerase II promoter
created_by: rl
creation_date: 2014-12-18T15:16:53Z

[Term]
id: GO:1903759
name: signal transduction involved in regulation of aerobic respiration
namespace: biological_process
def: "Any signal transduction that is involved in regulation of aerobic respiration." [GO_REF:0000060, GOC:TermGenie, PMID:19266076]
synonym: "signaling cascade involved in regulation of aerobic respiration" NARROW [GOC:TermGenie]
synonym: "signaling pathway involved in regulation of aerobic respiration" RELATED [GOC:TermGenie]
synonym: "signalling cascade involved in regulation of aerobic respiration" NARROW [GOC:TermGenie]
synonym: "signalling pathway involved in regulation of aerobic respiration" RELATED [GOC:TermGenie]
is_a: GO:0007165 ! signal transduction
intersection_of: GO:0007165 ! signal transduction
intersection_of: part_of GO:1903715 ! regulation of aerobic respiration
relationship: part_of GO:1903715 ! regulation of aerobic respiration
created_by: al
creation_date: 2014-12-18T16:37:50Z

[Term]
id: GO:1903760
name: regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization." [GO_REF:0000059, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18337493]
synonym: "regulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "regulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "regulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "regulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
is_a: GO:1901016 ! regulation of potassium ion transmembrane transporter activity
is_a: GO:1905024 ! regulation of membrane repolarization during ventricular cardiac muscle cell action potential
is_a: GO:2001257 ! regulation of cation channel activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1902282 ! voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
relationship: regulates GO:1902282 ! voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
created_by: rl
creation_date: 2014-12-19T12:01:59Z

[Term]
id: GO:1903761
name: negative regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization." [GO_REF:0000059, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18337493]
synonym: "down regulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "down regulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "down regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization" EXACT [GOC:TermGenie]
synonym: "down regulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "down regulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "down-regulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "down-regulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "down-regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization" EXACT [GOC:TermGenie]
synonym: "down-regulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "down-regulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "downregulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "downregulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "downregulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization" EXACT [GOC:TermGenie]
synonym: "downregulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "downregulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "inhibition of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "inhibition of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "inhibition of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization" NARROW [GOC:TermGenie]
synonym: "inhibition of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "inhibition of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "negative regulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "negative regulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "negative regulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "negative regulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
is_a: GO:1903760 ! regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
is_a: GO:1903817 ! negative regulation of voltage-gated potassium channel activity
is_a: GO:1905025 ! negative regulation of membrane repolarization during ventricular cardiac muscle cell action potential
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1902282 ! voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
relationship: negatively_regulates GO:1902282 ! voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
created_by: rl
creation_date: 2014-12-19T12:02:09Z

[Term]
id: GO:1903762
name: positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization." [GO_REF:0000059, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18337493]
synonym: "activation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "activation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "activation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization" NARROW [GOC:TermGenie]
synonym: "activation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "activation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "positive regulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "positive regulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "positive regulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "positive regulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up regulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "up regulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization" EXACT [GOC:TermGenie]
synonym: "up regulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up regulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up-regulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "up-regulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up-regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization" EXACT [GOC:TermGenie]
synonym: "up-regulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up-regulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "upregulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "upregulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "upregulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization" EXACT [GOC:TermGenie]
synonym: "upregulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "upregulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
is_a: GO:1903760 ! regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
is_a: GO:1903818 ! positive regulation of voltage-gated potassium channel activity
is_a: GO:1905026 ! positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1902282 ! voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
relationship: positively_regulates GO:1902282 ! voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
created_by: rl
creation_date: 2014-12-19T12:02:18Z

[Term]
id: GO:1903763
name: gap junction channel activity involved in cell communication by electrical coupling
namespace: molecular_function
def: "Any gap junction channel activity that is involved in cell communication by electrical coupling." [GO_REF:0000061, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:24587307]
synonym: "connexin involved in cell communication by electrical coupling" RELATED [GOC:TermGenie]
synonym: "innexin channel activity involved in cell communication by electrical coupling" EXACT [GOC:TermGenie]
synonym: "innexin involved in cell communication by electrical coupling" NARROW [GOC:TermGenie]
is_a: GO:0005243 ! gap junction channel activity
intersection_of: GO:0005243 ! gap junction channel activity
intersection_of: part_of GO:0010644 ! cell communication by electrical coupling
relationship: part_of GO:0010644 ! cell communication by electrical coupling
created_by: rl
creation_date: 2014-12-19T15:43:16Z

[Term]
id: GO:1903764
name: regulation of potassium ion export across plasma membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of potassium ion export across plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:19646991]
synonym: "regulation of potassium export across plasma membrane" BROAD [GOC:TermGenie]
is_a: GO:1902302 ! regulation of potassium ion export
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097623 ! potassium ion export across plasma membrane
relationship: regulates GO:0097623 ! potassium ion export across plasma membrane
created_by: rl
creation_date: 2014-12-19T16:30:03Z

[Term]
id: GO:1903765
name: negative regulation of potassium ion export across plasma membrane
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion export across plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:19646991]
synonym: "down regulation of potassium ion export across plasma membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of potassium ion export across plasma membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of potassium ion export across plasma membrane" EXACT [GOC:TermGenie]
synonym: "inhibition of potassium ion export across plasma membrane" NARROW [GOC:TermGenie]
is_a: GO:1902303 ! negative regulation of potassium ion export
is_a: GO:1903764 ! regulation of potassium ion export across plasma membrane
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097623 ! potassium ion export across plasma membrane
relationship: negatively_regulates GO:0097623 ! potassium ion export across plasma membrane
created_by: rl
creation_date: 2014-12-19T16:30:23Z

[Term]
id: GO:1903766
name: positive regulation of potassium ion export across plasma membrane
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of potassium ion export across plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:19646991]
synonym: "activation of potassium ion export across plasma membrane" NARROW [GOC:TermGenie]
synonym: "up regulation of potassium ion export across plasma membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of potassium ion export across plasma membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of potassium ion export across plasma membrane" EXACT [GOC:TermGenie]
is_a: GO:1902304 ! positive regulation of potassium ion export
is_a: GO:1903764 ! regulation of potassium ion export across plasma membrane
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097623 ! potassium ion export across plasma membrane
relationship: positively_regulates GO:0097623 ! potassium ion export across plasma membrane
created_by: rl
creation_date: 2014-12-19T16:30:32Z

[Term]
id: GO:1903767
name: sweet taste receptor complex
namespace: cellular_component
def: "A protein complex which is capable of sweet taste receptor activity." [GO_REF:0000088, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16720576]
is_a: GO:1903768 ! taste receptor complex
created_by: rl
creation_date: 2014-12-22T16:49:24Z

[Term]
id: GO:1903768
name: taste receptor complex
namespace: cellular_component
def: "A protein complex which is capable of taste receptor activity." [GO_REF:0000088, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16720576]
is_a: GO:0043235 ! receptor complex
created_by: rl
creation_date: 2014-12-22T16:53:45Z

[Term]
id: GO:1903769
name: negative regulation of cell proliferation in bone marrow
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation in bone marrow." [GO_REF:0000058, GOC:TermGenie, PMID:9241534]
synonym: "down regulation of bone marrow cell proliferation" EXACT [GOC:TermGenie]
synonym: "down regulation of cell proliferation in bone marrow" EXACT [GOC:TermGenie]
synonym: "down-regulation of bone marrow cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell proliferation in bone marrow" EXACT [GOC:TermGenie]
synonym: "downregulation of bone marrow cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of cell proliferation in bone marrow" EXACT [GOC:TermGenie]
synonym: "inhibition of bone marrow cell proliferation" NARROW [GOC:TermGenie]
synonym: "inhibition of cell proliferation in bone marrow" NARROW [GOC:TermGenie]
synonym: "negative regulation of bone marrow cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0008285 ! negative regulation of cell proliferation
is_a: GO:0071863 ! regulation of cell proliferation in bone marrow
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071838 ! cell proliferation in bone marrow
relationship: negatively_regulates GO:0071838 ! cell proliferation in bone marrow
created_by: sl
creation_date: 2014-12-29T19:46:26Z

[Term]
id: GO:1903770
name: negative regulation of beta-galactosidase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of beta-galactosidase activity." [GO_REF:0000059, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:11927518]
synonym: "down regulation of beta-D-galactanase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of beta-D-galactoside galactohydrolase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of beta-D-lactosidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of beta-galactosidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of beta-lactosidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of exo-(1->4)-beta-D-galactanase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of hydrolact" RELATED [GOC:TermGenie]
synonym: "down regulation of lactose hydrolysis" RELATED [GOC:TermGenie]
synonym: "down regulation of lactozym" RELATED [GOC:TermGenie]
synonym: "down regulation of maxilact" RELATED [GOC:TermGenie]
synonym: "down regulation of oryzatym" RELATED [GOC:TermGenie]
synonym: "down regulation of S 2107" RELATED [GOC:TermGenie]
synonym: "down regulation of sumiklat" RELATED [GOC:TermGenie]
synonym: "down regulation of trilactase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of beta-D-galactanase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of beta-D-galactoside galactohydrolase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of beta-D-lactosidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of beta-galactosidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of beta-lactosidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of exo-(1->4)-beta-D-galactanase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of hydrolact" RELATED [GOC:TermGenie]
synonym: "down-regulation of lactose hydrolysis" RELATED [GOC:TermGenie]
synonym: "down-regulation of lactozym" RELATED [GOC:TermGenie]
synonym: "down-regulation of maxilact" RELATED [GOC:TermGenie]
synonym: "down-regulation of oryzatym" RELATED [GOC:TermGenie]
synonym: "down-regulation of S 2107" RELATED [GOC:TermGenie]
synonym: "down-regulation of sumiklat" RELATED [GOC:TermGenie]
synonym: "down-regulation of trilactase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of beta-D-galactanase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of beta-D-galactoside galactohydrolase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of beta-D-lactosidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of beta-galactosidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of beta-lactosidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of exo-(1->4)-beta-D-galactanase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of hydrolact" RELATED [GOC:TermGenie]
synonym: "downregulation of lactose hydrolysis" RELATED [GOC:TermGenie]
synonym: "downregulation of lactozym" RELATED [GOC:TermGenie]
synonym: "downregulation of maxilact" RELATED [GOC:TermGenie]
synonym: "downregulation of oryzatym" RELATED [GOC:TermGenie]
synonym: "downregulation of S 2107" RELATED [GOC:TermGenie]
synonym: "downregulation of sumiklat" RELATED [GOC:TermGenie]
synonym: "downregulation of trilactase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of beta-D-galactanase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of beta-D-galactoside galactohydrolase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of beta-D-lactosidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of beta-galactosidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of beta-lactosidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of exo-(1->4)-beta-D-galactanase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of hydrolact" RELATED [GOC:TermGenie]
synonym: "inhibition of lactose hydrolysis" RELATED [GOC:TermGenie]
synonym: "inhibition of lactozym" RELATED [GOC:TermGenie]
synonym: "inhibition of maxilact" RELATED [GOC:TermGenie]
synonym: "inhibition of oryzatym" RELATED [GOC:TermGenie]
synonym: "inhibition of S 2107" RELATED [GOC:TermGenie]
synonym: "inhibition of sumiklat" RELATED [GOC:TermGenie]
synonym: "inhibition of trilactase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of beta-D-galactanase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of beta-D-galactoside galactohydrolase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of beta-D-lactosidase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of beta-lactosidase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of exo-(1->4)-beta-D-galactanase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of hydrolact" RELATED [GOC:TermGenie]
synonym: "negative regulation of lactose hydrolysis" RELATED [GOC:TermGenie]
synonym: "negative regulation of lactozym" RELATED [GOC:TermGenie]
synonym: "negative regulation of maxilact" RELATED [GOC:TermGenie]
synonym: "negative regulation of oryzatym" RELATED [GOC:TermGenie]
synonym: "negative regulation of S 2107" RELATED [GOC:TermGenie]
synonym: "negative regulation of sumiklat" RELATED [GOC:TermGenie]
synonym: "negative regulation of trilactase activity" EXACT [GOC:TermGenie]
is_a: GO:0051346 ! negative regulation of hydrolase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004565 ! beta-galactosidase activity
relationship: negatively_regulates GO:0004565 ! beta-galactosidase activity
created_by: nc
creation_date: 2015-01-06T10:53:22Z

[Term]
id: GO:1903771
name: positive regulation of beta-galactosidase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of beta-galactosidase activity." [GO_REF:0000059, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:11927518]
synonym: "activation of beta-D-galactanase activity" NARROW [GOC:TermGenie]
synonym: "activation of beta-D-galactoside galactohydrolase activity" NARROW [GOC:TermGenie]
synonym: "activation of beta-D-lactosidase activity" NARROW [GOC:TermGenie]
synonym: "activation of beta-galactosidase activity" NARROW [GOC:TermGenie]
synonym: "activation of beta-lactosidase activity" NARROW [GOC:TermGenie]
synonym: "activation of exo-(1->4)-beta-D-galactanase activity" NARROW [GOC:TermGenie]
synonym: "activation of hydrolact" RELATED [GOC:TermGenie]
synonym: "activation of lactose hydrolysis" RELATED [GOC:TermGenie]
synonym: "activation of lactozym" RELATED [GOC:TermGenie]
synonym: "activation of maxilact" RELATED [GOC:TermGenie]
synonym: "activation of oryzatym" RELATED [GOC:TermGenie]
synonym: "activation of S 2107" RELATED [GOC:TermGenie]
synonym: "activation of sumiklat" RELATED [GOC:TermGenie]
synonym: "activation of trilactase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of beta-D-galactanase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of beta-D-galactoside galactohydrolase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of beta-D-lactosidase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of beta-lactosidase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of exo-(1->4)-beta-D-galactanase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of hydrolact" RELATED [GOC:TermGenie]
synonym: "positive regulation of lactose hydrolysis" RELATED [GOC:TermGenie]
synonym: "positive regulation of lactozym" RELATED [GOC:TermGenie]
synonym: "positive regulation of maxilact" RELATED [GOC:TermGenie]
synonym: "positive regulation of oryzatym" RELATED [GOC:TermGenie]
synonym: "positive regulation of S 2107" RELATED [GOC:TermGenie]
synonym: "positive regulation of sumiklat" RELATED [GOC:TermGenie]
synonym: "positive regulation of trilactase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of beta-D-galactanase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of beta-D-galactoside galactohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of beta-D-lactosidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of beta-galactosidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of beta-lactosidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of exo-(1->4)-beta-D-galactanase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of hydrolact" RELATED [GOC:TermGenie]
synonym: "up regulation of lactose hydrolysis" RELATED [GOC:TermGenie]
synonym: "up regulation of lactozym" RELATED [GOC:TermGenie]
synonym: "up regulation of maxilact" RELATED [GOC:TermGenie]
synonym: "up regulation of oryzatym" RELATED [GOC:TermGenie]
synonym: "up regulation of S 2107" RELATED [GOC:TermGenie]
synonym: "up regulation of sumiklat" RELATED [GOC:TermGenie]
synonym: "up regulation of trilactase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of beta-D-galactanase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of beta-D-galactoside galactohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of beta-D-lactosidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of beta-galactosidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of beta-lactosidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of exo-(1->4)-beta-D-galactanase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of hydrolact" RELATED [GOC:TermGenie]
synonym: "up-regulation of lactose hydrolysis" RELATED [GOC:TermGenie]
synonym: "up-regulation of lactozym" RELATED [GOC:TermGenie]
synonym: "up-regulation of maxilact" RELATED [GOC:TermGenie]
synonym: "up-regulation of oryzatym" RELATED [GOC:TermGenie]
synonym: "up-regulation of S 2107" RELATED [GOC:TermGenie]
synonym: "up-regulation of sumiklat" RELATED [GOC:TermGenie]
synonym: "up-regulation of trilactase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of beta-D-galactanase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of beta-D-galactoside galactohydrolase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of beta-D-lactosidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of beta-galactosidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of beta-lactosidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of exo-(1->4)-beta-D-galactanase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of hydrolact" RELATED [GOC:TermGenie]
synonym: "upregulation of lactose hydrolysis" RELATED [GOC:TermGenie]
synonym: "upregulation of lactozym" RELATED [GOC:TermGenie]
synonym: "upregulation of maxilact" RELATED [GOC:TermGenie]
synonym: "upregulation of oryzatym" RELATED [GOC:TermGenie]
synonym: "upregulation of S 2107" RELATED [GOC:TermGenie]
synonym: "upregulation of sumiklat" RELATED [GOC:TermGenie]
synonym: "upregulation of trilactase activity" EXACT [GOC:TermGenie]
is_a: GO:0051345 ! positive regulation of hydrolase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004565 ! beta-galactosidase activity
relationship: positively_regulates GO:0004565 ! beta-galactosidase activity
created_by: nc
creation_date: 2015-01-06T10:53:32Z

[Term]
id: GO:1903772
name: regulation of viral budding via host ESCRT complex
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of viral budding via host ESCRT complex." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24878737]
synonym: "regulation of host-assisted viral budding" BROAD [GOC:TermGenie]
synonym: "regulation of viral budding through the ESCRT machinery" RELATED [GOC:TermGenie]
is_a: GO:0033043 ! regulation of organelle organization
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0060627 ! regulation of vesicle-mediated transport
is_a: GO:1903900 ! regulation of viral life cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0039702 ! viral budding via host ESCRT complex
relationship: regulates GO:0039702 ! viral budding via host ESCRT complex
created_by: als
creation_date: 2015-01-06T16:20:43Z

[Term]
id: GO:1903773
name: negative regulation of viral budding via host ESCRT complex
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of viral budding via host ESCRT complex." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24878737]
synonym: "down regulation of viral budding through the ESCRT machinery" RELATED [GOC:TermGenie]
synonym: "down regulation of viral budding via host ESCRT complex" EXACT [GOC:TermGenie]
synonym: "down-regulation of viral budding through the ESCRT machinery" RELATED [GOC:TermGenie]
synonym: "down-regulation of viral budding via host ESCRT complex" EXACT [GOC:TermGenie]
synonym: "downregulation of viral budding through the ESCRT machinery" RELATED [GOC:TermGenie]
synonym: "downregulation of viral budding via host ESCRT complex" EXACT [GOC:TermGenie]
synonym: "inhibition of viral budding through the ESCRT machinery" RELATED [GOC:TermGenie]
synonym: "inhibition of viral budding via host ESCRT complex" NARROW [GOC:TermGenie]
synonym: "negative regulation of viral budding through the ESCRT machinery" RELATED [GOC:TermGenie]
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:1903772 ! regulation of viral budding via host ESCRT complex
is_a: GO:1903901 ! negative regulation of viral life cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0039702 ! viral budding via host ESCRT complex
relationship: negatively_regulates GO:0039702 ! viral budding via host ESCRT complex
created_by: als
creation_date: 2015-01-06T16:20:53Z

[Term]
id: GO:1903774
name: positive regulation of viral budding via host ESCRT complex
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of viral budding via host ESCRT complex." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24878737]
synonym: "activation of viral budding through the ESCRT machinery" RELATED [GOC:TermGenie]
synonym: "activation of viral budding via host ESCRT complex" NARROW [GOC:TermGenie]
synonym: "positive regulation of viral budding through the ESCRT machinery" RELATED [GOC:TermGenie]
synonym: "up regulation of viral budding through the ESCRT machinery" RELATED [GOC:TermGenie]
synonym: "up regulation of viral budding via host ESCRT complex" EXACT [GOC:TermGenie]
synonym: "up-regulation of viral budding through the ESCRT machinery" RELATED [GOC:TermGenie]
synonym: "up-regulation of viral budding via host ESCRT complex" EXACT [GOC:TermGenie]
synonym: "upregulation of viral budding through the ESCRT machinery" RELATED [GOC:TermGenie]
synonym: "upregulation of viral budding via host ESCRT complex" EXACT [GOC:TermGenie]
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:1903772 ! regulation of viral budding via host ESCRT complex
is_a: GO:1903902 ! positive regulation of viral life cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0039702 ! viral budding via host ESCRT complex
relationship: positively_regulates GO:0039702 ! viral budding via host ESCRT complex
created_by: als
creation_date: 2015-01-06T16:21:02Z

[Term]
id: GO:1903775
name: regulation of DNA double-strand break processing
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA double-strand break processing." [GO_REF:0000058, GOC:TermGenie, PMID:25203555]
is_a: GO:2000779 ! regulation of double-strand break repair
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000729 ! DNA double-strand break processing
relationship: regulates GO:0000729 ! DNA double-strand break processing
created_by: al
creation_date: 2015-01-06T17:08:15Z

[Term]
id: GO:1903776
name: regulation of double-strand break repair via single-strand annealing, removal of nonhomologous ends
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of double-strand break repair via single-strand annealing, removal of nonhomologous ends." [GO_REF:0000058, GOC:TermGenie, PMID:25203555]
is_a: GO:0000019 ! regulation of mitotic recombination
is_a: GO:0031494 ! regulation of mating type switching
is_a: GO:2000779 ! regulation of double-strand break repair
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000736 ! double-strand break repair via single-strand annealing, removal of nonhomologous ends
relationship: regulates GO:0000736 ! double-strand break repair via single-strand annealing, removal of nonhomologous ends
created_by: al
creation_date: 2015-01-06T17:08:24Z

[Term]
id: GO:1903777
name: melibiose binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with melibiose." [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:11471732]
is_a: GO:0048030 ! disaccharide binding
created_by: mr
creation_date: 2015-01-06T21:05:29Z

[Term]
id: GO:1903778
name: protein localization to vacuolar membrane
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a vacuolar membrane." [GO_REF:0000087, GOC:TermGenie, PMID:25378562]
synonym: "protein localisation in vacuolar membrane" EXACT [GOC:TermGenie]
synonym: "protein localisation to vacuolar membrane" EXACT [GOC:TermGenie]
synonym: "protein localization in vacuolar membrane" EXACT [GOC:TermGenie]
is_a: GO:0072657 ! protein localization to membrane
is_a: GO:0072665 ! protein localization to vacuole
created_by: mah
creation_date: 2015-01-07T13:15:54Z

[Term]
id: GO:1903779
name: regulation of cardiac conduction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac conduction." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:12967627]
is_a: GO:0008016 ! regulation of heart contraction
is_a: GO:0023051 ! regulation of signaling
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061337 ! cardiac conduction
relationship: regulates GO:0061337 ! cardiac conduction
created_by: rph
creation_date: 2015-01-07T13:20:11Z

[Term]
id: GO:1903780
name: negative regulation of cardiac conduction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac conduction." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:12967627]
synonym: "down regulation of cardiac conduction" EXACT [GOC:TermGenie]
synonym: "down-regulation of cardiac conduction" EXACT [GOC:TermGenie]
synonym: "downregulation of cardiac conduction" EXACT [GOC:TermGenie]
synonym: "inhibition of cardiac conduction" NARROW [GOC:TermGenie]
is_a: GO:0023057 ! negative regulation of signaling
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1903779 ! regulation of cardiac conduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061337 ! cardiac conduction
relationship: negatively_regulates GO:0061337 ! cardiac conduction
created_by: rph
creation_date: 2015-01-07T13:20:20Z

[Term]
id: GO:1903781
name: positive regulation of cardiac conduction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiac conduction." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:12967627]
synonym: "activation of cardiac conduction" NARROW [GOC:TermGenie]
synonym: "up regulation of cardiac conduction" EXACT [GOC:TermGenie]
synonym: "up-regulation of cardiac conduction" EXACT [GOC:TermGenie]
synonym: "upregulation of cardiac conduction" EXACT [GOC:TermGenie]
is_a: GO:0023056 ! positive regulation of signaling
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1903779 ! regulation of cardiac conduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061337 ! cardiac conduction
relationship: positively_regulates GO:0061337 ! cardiac conduction
created_by: rph
creation_date: 2015-01-07T13:20:28Z

[Term]
id: GO:1903782
name: regulation of sodium ion import across plasma membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sodium ion import across plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:19376779]
is_a: GO:1902305 ! regulation of sodium ion transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0098719 ! sodium ion import across plasma membrane
relationship: regulates GO:0098719 ! sodium ion import across plasma membrane
created_by: nc
creation_date: 2015-01-07T16:48:43Z

[Term]
id: GO:1903783
name: negative regulation of sodium ion import across plasma membrane
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion import across plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:19376779]
synonym: "down regulation of sodium ion import across plasma membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of sodium ion import across plasma membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of sodium ion import across plasma membrane" EXACT [GOC:TermGenie]
synonym: "inhibition of sodium ion import across plasma membrane" NARROW [GOC:TermGenie]
is_a: GO:1902306 ! negative regulation of sodium ion transmembrane transport
is_a: GO:1903782 ! regulation of sodium ion import across plasma membrane
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0098719 ! sodium ion import across plasma membrane
relationship: negatively_regulates GO:0098719 ! sodium ion import across plasma membrane
created_by: nc
creation_date: 2015-01-07T16:48:51Z

[Term]
id: GO:1903784
name: positive regulation of sodium ion import across plasma membrane
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sodium ion import across plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:19376779]
synonym: "activation of sodium ion import across plasma membrane" NARROW [GOC:TermGenie]
synonym: "up regulation of sodium ion import across plasma membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of sodium ion import across plasma membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of sodium ion import across plasma membrane" EXACT [GOC:TermGenie]
is_a: GO:1902307 ! positive regulation of sodium ion transmembrane transport
is_a: GO:1903782 ! regulation of sodium ion import across plasma membrane
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0098719 ! sodium ion import across plasma membrane
relationship: positively_regulates GO:0098719 ! sodium ion import across plasma membrane
created_by: nc
creation_date: 2015-01-07T16:49:00Z

[Term]
id: GO:1903785
name: L-valine transmembrane transport
namespace: biological_process
def: "The directed movement of L-valine across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:20944394]
is_a: GO:0015829 ! valine transport
is_a: GO:0098655 ! cation transmembrane transport
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport
created_by: al
creation_date: 2015-01-08T14:50:32Z

[Term]
id: GO:1903786
name: regulation of glutathione biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glutathione biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "regulation of glutathione anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of glutathione biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of glutathione formation" EXACT [GOC:TermGenie]
synonym: "regulation of glutathione synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0034248 ! regulation of cellular amide metabolic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006750 ! glutathione biosynthetic process
relationship: regulates GO:0006750 ! glutathione biosynthetic process
created_by: bf
creation_date: 2015-01-08T17:14:49Z

[Term]
id: GO:1903787
name: negative regulation of glutathione biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glutathione biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "down regulation of glutathione anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of glutathione biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of glutathione biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of glutathione formation" EXACT [GOC:TermGenie]
synonym: "down regulation of glutathione synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of glutathione anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of glutathione biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of glutathione biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of glutathione formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of glutathione synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of glutathione anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of glutathione biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of glutathione biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of glutathione formation" EXACT [GOC:TermGenie]
synonym: "downregulation of glutathione synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of glutathione anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of glutathione biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of glutathione biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of glutathione formation" NARROW [GOC:TermGenie]
synonym: "inhibition of glutathione synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of glutathione anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of glutathione biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of glutathione formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of glutathione synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0034249 ! negative regulation of cellular amide metabolic process
is_a: GO:0051175 ! negative regulation of sulfur metabolic process
is_a: GO:1903786 ! regulation of glutathione biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006750 ! glutathione biosynthetic process
relationship: negatively_regulates GO:0006750 ! glutathione biosynthetic process
created_by: bf
creation_date: 2015-01-08T17:14:59Z

[Term]
id: GO:1903788
name: positive regulation of glutathione biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glutathione biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "activation of glutathione anabolism" NARROW [GOC:TermGenie]
synonym: "activation of glutathione biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of glutathione biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of glutathione formation" NARROW [GOC:TermGenie]
synonym: "activation of glutathione synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of glutathione anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of glutathione biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of glutathione formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of glutathione synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of glutathione anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of glutathione biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of glutathione biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of glutathione formation" EXACT [GOC:TermGenie]
synonym: "up regulation of glutathione synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of glutathione anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of glutathione biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of glutathione biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of glutathione formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of glutathione synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of glutathione anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of glutathione biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of glutathione biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of glutathione formation" EXACT [GOC:TermGenie]
synonym: "upregulation of glutathione synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0034250 ! positive regulation of cellular amide metabolic process
is_a: GO:0051176 ! positive regulation of sulfur metabolic process
is_a: GO:1903786 ! regulation of glutathione biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006750 ! glutathione biosynthetic process
relationship: positively_regulates GO:0006750 ! glutathione biosynthetic process
created_by: bf
creation_date: 2015-01-08T17:15:07Z

[Term]
id: GO:1903789
name: regulation of amino acid transmembrane transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of amino acid transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:16115814]
synonym: "regulation of amino acid membrane transport" EXACT [GOC:TermGenie]
is_a: GO:0051955 ! regulation of amino acid transport
is_a: GO:1903959 ! regulation of anion transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003333 ! amino acid transmembrane transport
relationship: regulates GO:0003333 ! amino acid transmembrane transport
created_by: al
creation_date: 2015-01-08T17:42:18Z

[Term]
id: GO:1903790
name: guanine nucleotide transmembrane transport
namespace: biological_process
def: "The directed movement of guanyl nucleotide across a membrane." [GO_REF:0000069, GOC:dph, GOC:TermGenie, GOC:vw, PMID:25320081]
synonym: "guanyl nucleotide transmembrane transport" EXACT []
is_a: GO:0001408 ! guanine nucleotide transport
is_a: GO:0072530 ! purine-containing compound transmembrane transport
is_a: GO:1901642 ! nucleoside transmembrane transport
is_a: GO:1901679 ! nucleotide transmembrane transport
created_by: dph
creation_date: 2015-01-10T13:51:54Z

[Term]
id: GO:1903791
name: uracil transmembrane transport
namespace: biological_process
def: "The directed movement of uracil across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:8948441]
is_a: GO:0015857 ! uracil transport
is_a: GO:1904082 ! pyrimidine nucleobase transmembrane transport
created_by: vw
creation_date: 2015-01-12T10:15:25Z

[Term]
id: GO:1903792
name: negative regulation of anion transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of anion transport." [GO_REF:0000058, GOC:TermGenie, PMID:11336802]
synonym: "down regulation of anion transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of anion transport" EXACT [GOC:TermGenie]
synonym: "downregulation of anion transport" EXACT [GOC:TermGenie]
synonym: "inhibition of anion transport" NARROW [GOC:TermGenie]
is_a: GO:0043271 ! negative regulation of ion transport
is_a: GO:0044070 ! regulation of anion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006820 ! anion transport
relationship: negatively_regulates GO:0006820 ! anion transport
created_by: sl
creation_date: 2015-01-12T21:50:20Z

[Term]
id: GO:1903793
name: positive regulation of anion transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of anion transport." [GO_REF:0000058, GOC:TermGenie, PMID:11336802]
synonym: "activation of anion transport" NARROW [GOC:TermGenie]
synonym: "up regulation of anion transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of anion transport" EXACT [GOC:TermGenie]
synonym: "upregulation of anion transport" EXACT [GOC:TermGenie]
is_a: GO:0043270 ! positive regulation of ion transport
is_a: GO:0044070 ! regulation of anion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006820 ! anion transport
relationship: positively_regulates GO:0006820 ! anion transport
created_by: sl
creation_date: 2015-01-12T21:50:30Z

[Term]
id: GO:1903794
name: cortisol binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with cortisol." [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:18483153]
is_a: GO:0043178 ! alcohol binding
is_a: GO:1990239 ! steroid hormone binding
created_by: mr
creation_date: 2015-01-14T19:02:31Z

[Term]
id: GO:1903795
name: regulation of inorganic anion transmembrane transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of inorganic anion transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:11336802]
synonym: "regulation of inorganic anion membrane transport" EXACT [GOC:TermGenie]
synonym: "regulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie]
is_a: GO:1903959 ! regulation of anion transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0098661 ! inorganic anion transmembrane transport
relationship: regulates GO:0098661 ! inorganic anion transmembrane transport
created_by: sl
creation_date: 2015-01-14T21:44:49Z

[Term]
id: GO:1903796
name: negative regulation of inorganic anion transmembrane transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of inorganic anion transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:11336802]
synonym: "down regulation of inorganic anion membrane transport" EXACT [GOC:TermGenie]
synonym: "down regulation of inorganic anion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "down regulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of inorganic anion membrane transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of inorganic anion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie]
synonym: "downregulation of inorganic anion membrane transport" EXACT [GOC:TermGenie]
synonym: "downregulation of inorganic anion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "downregulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie]
synonym: "inhibition of inorganic anion membrane transport" NARROW [GOC:TermGenie]
synonym: "inhibition of inorganic anion transmembrane transport" NARROW [GOC:TermGenie]
synonym: "inhibition of transmembrane inorganic anion transport" NARROW [GOC:TermGenie]
synonym: "negative regulation of inorganic anion membrane transport" EXACT [GOC:TermGenie]
synonym: "negative regulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie]
is_a: GO:1903795 ! regulation of inorganic anion transmembrane transport
is_a: GO:1903960 ! negative regulation of anion transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0098661 ! inorganic anion transmembrane transport
relationship: negatively_regulates GO:0098661 ! inorganic anion transmembrane transport
created_by: sl
creation_date: 2015-01-14T21:44:59Z

[Term]
id: GO:1903797
name: positive regulation of inorganic anion transmembrane transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of inorganic anion transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:11336802]
synonym: "activation of inorganic anion membrane transport" NARROW [GOC:TermGenie]
synonym: "activation of inorganic anion transmembrane transport" NARROW [GOC:TermGenie]
synonym: "activation of transmembrane inorganic anion transport" NARROW [GOC:TermGenie]
synonym: "positive regulation of inorganic anion membrane transport" EXACT [GOC:TermGenie]
synonym: "positive regulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie]
synonym: "up regulation of inorganic anion membrane transport" EXACT [GOC:TermGenie]
synonym: "up regulation of inorganic anion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "up regulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of inorganic anion membrane transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of inorganic anion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie]
synonym: "upregulation of inorganic anion membrane transport" EXACT [GOC:TermGenie]
synonym: "upregulation of inorganic anion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "upregulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie]
is_a: GO:1903795 ! regulation of inorganic anion transmembrane transport
is_a: GO:1903961 ! positive regulation of anion transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0098661 ! inorganic anion transmembrane transport
relationship: positively_regulates GO:0098661 ! inorganic anion transmembrane transport
created_by: sl
creation_date: 2015-01-14T21:45:08Z

[Term]
id: GO:1903798
name: regulation of production of miRNAs involved in gene silencing by miRNA
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of production of miRNAs involved in gene silencing by miRNA." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326]
synonym: "regulation of gene silencing by miRNA, production of miRNAs" EXACT [GOC:TermGenie]
synonym: "regulation of microRNA biogenesis" RELATED [GOC:TermGenie]
synonym: "regulation of microRNA biosynthesis" RELATED [GOC:TermGenie]
synonym: "regulation of microRNA biosynthetic process" RELATED [GOC:TermGenie]
synonym: "regulation of microRNA metabolic process" RELATED [GOC:TermGenie]
synonym: "regulation of microRNA metabolism" RELATED [GOC:TermGenie]
synonym: "regulation of microRNA processing" BROAD [GOC:TermGenie]
synonym: "regulation of microRNA-mediated gene silencing, production of microRNAs" EXACT [GOC:TermGenie]
synonym: "regulation of miRNA biogenesis" RELATED [GOC:TermGenie]
synonym: "regulation of miRNA processing" EXACT [GOC:TermGenie]
synonym: "regulation of miRNA-mediated gene silencing, production of miRNAs" EXACT [GOC:TermGenie]
synonym: "regulation of production of microRNAs involved in gene silencing by microRNA" EXACT [GOC:TermGenie]
is_a: GO:0060964 ! regulation of gene silencing by miRNA
is_a: GO:0070920 ! regulation of production of small RNA involved in gene silencing by RNA
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035196 ! production of miRNAs involved in gene silencing by miRNA
relationship: regulates GO:0035196 ! production of miRNAs involved in gene silencing by miRNA
created_by: rph
creation_date: 2015-01-15T13:58:12Z

[Term]
id: GO:1903799
name: negative regulation of production of miRNAs involved in gene silencing by miRNA
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of production of miRNAs involved in gene silencing by miRNA." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326]
synonym: "down regulation of gene silencing by miRNA, production of miRNAs" EXACT [GOC:TermGenie]
synonym: "down regulation of microRNA biogenesis" RELATED [GOC:TermGenie]
synonym: "down regulation of microRNA biosynthesis" RELATED [GOC:TermGenie]
synonym: "down regulation of microRNA biosynthetic process" RELATED [GOC:TermGenie]
synonym: "down regulation of microRNA metabolic process" RELATED [GOC:TermGenie]
synonym: "down regulation of microRNA metabolism" RELATED [GOC:TermGenie]
synonym: "down regulation of microRNA-mediated gene silencing, production of microRNAs" EXACT [GOC:TermGenie]
synonym: "down regulation of miRNA biogenesis" RELATED [GOC:TermGenie]
synonym: "down regulation of miRNA processing" EXACT [GOC:TermGenie]
synonym: "down regulation of miRNA-mediated gene silencing, production of miRNAs" EXACT [GOC:TermGenie]
synonym: "down regulation of production of microRNAs involved in gene silencing by microRNA" EXACT [GOC:TermGenie]
synonym: "down regulation of production of miRNAs involved in gene silencing by miRNA" EXACT [GOC:TermGenie]
synonym: "down-regulation of gene silencing by miRNA, production of miRNAs" EXACT [GOC:TermGenie]
synonym: "down-regulation of microRNA biogenesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of microRNA biosynthesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of microRNA biosynthetic process" RELATED [GOC:TermGenie]
synonym: "down-regulation of microRNA metabolic process" RELATED [GOC:TermGenie]
synonym: "down-regulation of microRNA metabolism" RELATED [GOC:TermGenie]
synonym: "down-regulation of microRNA-mediated gene silencing, production of microRNAs" EXACT [GOC:TermGenie]
synonym: "down-regulation of miRNA biogenesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of miRNA processing" EXACT [GOC:TermGenie]
synonym: "down-regulation of miRNA-mediated gene silencing, production of miRNAs" EXACT [GOC:TermGenie]
synonym: "down-regulation of production of microRNAs involved in gene silencing by microRNA" EXACT [GOC:TermGenie]
synonym: "down-regulation of production of miRNAs involved in gene silencing by miRNA" EXACT [GOC:TermGenie]
synonym: "downregulation of gene silencing by miRNA, production of miRNAs" EXACT [GOC:TermGenie]
synonym: "downregulation of microRNA biogenesis" RELATED [GOC:TermGenie]
synonym: "downregulation of microRNA biosynthesis" RELATED [GOC:TermGenie]
synonym: "downregulation of microRNA biosynthetic process" RELATED [GOC:TermGenie]
synonym: "downregulation of microRNA metabolic process" RELATED [GOC:TermGenie]
synonym: "downregulation of microRNA metabolism" RELATED [GOC:TermGenie]
synonym: "downregulation of microRNA-mediated gene silencing, production of microRNAs" EXACT [GOC:TermGenie]
synonym: "downregulation of miRNA biogenesis" RELATED [GOC:TermGenie]
synonym: "downregulation of miRNA processing" EXACT [GOC:TermGenie]
synonym: "downregulation of miRNA-mediated gene silencing, production of miRNAs" EXACT [GOC:TermGenie]
synonym: "downregulation of production of microRNAs involved in gene silencing by microRNA" EXACT [GOC:TermGenie]
synonym: "downregulation of production of miRNAs involved in gene silencing by miRNA" EXACT [GOC:TermGenie]
synonym: "inhibition of gene silencing by miRNA, production of miRNAs" NARROW [GOC:TermGenie]
synonym: "inhibition of microRNA biogenesis" RELATED [GOC:TermGenie]
synonym: "inhibition of microRNA biosynthesis" RELATED [GOC:TermGenie]
synonym: "inhibition of microRNA biosynthetic process" RELATED [GOC:TermGenie]
synonym: "inhibition of microRNA metabolic process" RELATED [GOC:TermGenie]
synonym: "inhibition of microRNA metabolism" RELATED [GOC:TermGenie]
synonym: "inhibition of microRNA-mediated gene silencing, production of microRNAs" NARROW [GOC:TermGenie]
synonym: "inhibition of miRNA biogenesis" RELATED [GOC:TermGenie]
synonym: "inhibition of miRNA processing" NARROW [GOC:TermGenie]
synonym: "inhibition of miRNA-mediated gene silencing, production of miRNAs" NARROW [GOC:TermGenie]
synonym: "inhibition of production of microRNAs involved in gene silencing by microRNA" NARROW [GOC:TermGenie]
synonym: "inhibition of production of miRNAs involved in gene silencing by miRNA" NARROW [GOC:TermGenie]
synonym: "negative regulation of gene silencing by miRNA, production of miRNAs" EXACT [GOC:TermGenie]
synonym: "negative regulation of microRNA biogenesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of microRNA biosynthesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of microRNA biosynthetic process" RELATED [GOC:TermGenie]
synonym: "negative regulation of microRNA metabolic process" RELATED [GOC:TermGenie]
synonym: "negative regulation of microRNA metabolism" RELATED [GOC:TermGenie]
synonym: "negative regulation of microRNA-mediated gene silencing, production of microRNAs" EXACT [GOC:TermGenie]
synonym: "negative regulation of miRNA biogenesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of miRNA processing" EXACT [GOC:TermGenie]
synonym: "negative regulation of miRNA-mediated gene silencing, production of miRNAs" EXACT [GOC:TermGenie]
synonym: "negative regulation of production of microRNAs involved in gene silencing by microRNA" EXACT [GOC:TermGenie]
is_a: GO:0010629 ! negative regulation of gene expression
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:0051253 ! negative regulation of RNA metabolic process
is_a: GO:0060965 ! negative regulation of gene silencing by miRNA
is_a: GO:1903798 ! regulation of production of miRNAs involved in gene silencing by miRNA
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035196 ! production of miRNAs involved in gene silencing by miRNA
relationship: negatively_regulates GO:0035196 ! production of miRNAs involved in gene silencing by miRNA
created_by: rph
creation_date: 2015-01-15T13:58:22Z

[Term]
id: GO:1903800
name: positive regulation of production of miRNAs involved in gene silencing by miRNA
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of production of miRNAs involved in gene silencing by miRNA." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326]
synonym: "activation of gene silencing by miRNA, production of miRNAs" NARROW [GOC:TermGenie]
synonym: "activation of microRNA biogenesis" RELATED [GOC:TermGenie]
synonym: "activation of microRNA biosynthesis" RELATED [GOC:TermGenie]
synonym: "activation of microRNA biosynthetic process" RELATED [GOC:TermGenie]
synonym: "activation of microRNA metabolic process" RELATED [GOC:TermGenie]
synonym: "activation of microRNA metabolism" RELATED [GOC:TermGenie]
synonym: "activation of microRNA-mediated gene silencing, production of microRNAs" NARROW [GOC:TermGenie]
synonym: "activation of miRNA biogenesis" RELATED [GOC:TermGenie]
synonym: "activation of miRNA processing" NARROW [GOC:TermGenie]
synonym: "activation of miRNA-mediated gene silencing, production of miRNAs" NARROW [GOC:TermGenie]
synonym: "activation of production of microRNAs involved in gene silencing by microRNA" NARROW [GOC:TermGenie]
synonym: "activation of production of miRNAs involved in gene silencing by miRNA" NARROW [GOC:TermGenie]
synonym: "positive regulation of gene silencing by miRNA, production of miRNAs" EXACT [GOC:TermGenie]
synonym: "positive regulation of microRNA biogenesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of microRNA biosynthesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of microRNA biosynthetic process" RELATED [GOC:TermGenie]
synonym: "positive regulation of microRNA metabolic process" RELATED [GOC:TermGenie]
synonym: "positive regulation of microRNA metabolism" RELATED [GOC:TermGenie]
synonym: "positive regulation of microRNA-mediated gene silencing, production of microRNAs" EXACT [GOC:TermGenie]
synonym: "positive regulation of miRNA biogenesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of miRNA processing" EXACT [GOC:TermGenie]
synonym: "positive regulation of miRNA-mediated gene silencing, production of miRNAs" EXACT [GOC:TermGenie]
synonym: "positive regulation of production of microRNAs involved in gene silencing by microRNA" EXACT [GOC:TermGenie]
synonym: "up regulation of gene silencing by miRNA, production of miRNAs" EXACT [GOC:TermGenie]
synonym: "up regulation of microRNA biogenesis" RELATED [GOC:TermGenie]
synonym: "up regulation of microRNA biosynthesis" RELATED [GOC:TermGenie]
synonym: "up regulation of microRNA biosynthetic process" RELATED [GOC:TermGenie]
synonym: "up regulation of microRNA metabolic process" RELATED [GOC:TermGenie]
synonym: "up regulation of microRNA metabolism" RELATED [GOC:TermGenie]
synonym: "up regulation of microRNA-mediated gene silencing, production of microRNAs" EXACT [GOC:TermGenie]
synonym: "up regulation of miRNA biogenesis" RELATED [GOC:TermGenie]
synonym: "up regulation of miRNA processing" EXACT [GOC:TermGenie]
synonym: "up regulation of miRNA-mediated gene silencing, production of miRNAs" EXACT [GOC:TermGenie]
synonym: "up regulation of production of microRNAs involved in gene silencing by microRNA" EXACT [GOC:TermGenie]
synonym: "up regulation of production of miRNAs involved in gene silencing by miRNA" EXACT [GOC:TermGenie]
synonym: "up-regulation of gene silencing by miRNA, production of miRNAs" EXACT [GOC:TermGenie]
synonym: "up-regulation of microRNA biogenesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of microRNA biosynthesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of microRNA biosynthetic process" RELATED [GOC:TermGenie]
synonym: "up-regulation of microRNA metabolic process" RELATED [GOC:TermGenie]
synonym: "up-regulation of microRNA metabolism" RELATED [GOC:TermGenie]
synonym: "up-regulation of microRNA-mediated gene silencing, production of microRNAs" EXACT [GOC:TermGenie]
synonym: "up-regulation of miRNA biogenesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of miRNA processing" EXACT [GOC:TermGenie]
synonym: "up-regulation of miRNA-mediated gene silencing, production of miRNAs" EXACT [GOC:TermGenie]
synonym: "up-regulation of production of microRNAs involved in gene silencing by microRNA" EXACT [GOC:TermGenie]
synonym: "up-regulation of production of miRNAs involved in gene silencing by miRNA" EXACT [GOC:TermGenie]
synonym: "upregulation of gene silencing by miRNA, production of miRNAs" EXACT [GOC:TermGenie]
synonym: "upregulation of microRNA biogenesis" RELATED [GOC:TermGenie]
synonym: "upregulation of microRNA biosynthesis" RELATED [GOC:TermGenie]
synonym: "upregulation of microRNA biosynthetic process" RELATED [GOC:TermGenie]
synonym: "upregulation of microRNA metabolic process" RELATED [GOC:TermGenie]
synonym: "upregulation of microRNA metabolism" RELATED [GOC:TermGenie]
synonym: "upregulation of microRNA-mediated gene silencing, production of microRNAs" EXACT [GOC:TermGenie]
synonym: "upregulation of miRNA biogenesis" RELATED [GOC:TermGenie]
synonym: "upregulation of miRNA processing" EXACT [GOC:TermGenie]
synonym: "upregulation of miRNA-mediated gene silencing, production of miRNAs" EXACT [GOC:TermGenie]
synonym: "upregulation of production of microRNAs involved in gene silencing by microRNA" EXACT [GOC:TermGenie]
synonym: "upregulation of production of miRNAs involved in gene silencing by miRNA" EXACT [GOC:TermGenie]
is_a: GO:0010628 ! positive regulation of gene expression
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:0051254 ! positive regulation of RNA metabolic process
is_a: GO:1903798 ! regulation of production of miRNAs involved in gene silencing by miRNA
is_a: GO:2000637 ! positive regulation of gene silencing by miRNA
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035196 ! production of miRNAs involved in gene silencing by miRNA
relationship: positively_regulates GO:0035196 ! production of miRNAs involved in gene silencing by miRNA
created_by: rph
creation_date: 2015-01-15T13:58:31Z

[Term]
id: GO:1903801
name: L-leucine import into cell
namespace: biological_process
def: "The directed movement of L-leucine into a cell." [GO_REF:0000075, GOC:TermGenie, PMID:23895341]
is_a: GO:0043092 ! L-amino acid import
is_a: GO:0060356 ! leucine import
created_by: mah
creation_date: 2015-01-16T14:34:46Z

[Term]
id: GO:1903802
name: L-glutamate(1-) import into cell
namespace: biological_process
def: "The directed movement of L-glutamate(1-) into a cell." [GO_REF:0000075, GOC:TermGenie, PMID:23895341]
is_a: GO:0051938 ! L-glutamate import
created_by: mah
creation_date: 2015-01-16T14:34:56Z

[Term]
id: GO:1903803
name: L-glutamine import into cell
namespace: biological_process
def: "The directed movement of L-glutamine into a cell." [GO_REF:0000075, GOC:TermGenie, PMID:23895341]
is_a: GO:0036229 ! L-glutamine import
created_by: mah
creation_date: 2015-01-16T14:35:05Z

[Term]
id: GO:1903804
name: glycine import into cell
namespace: biological_process
def: "The directed movement of glycine into a cell." [GO_REF:0000075, GOC:TermGenie, PMID:23895341]
is_a: GO:0036233 ! glycine import
created_by: mah
creation_date: 2015-01-16T14:35:14Z

[Term]
id: GO:1903805
name: L-valine import into cell
namespace: biological_process
def: "The directed movement of L-valine into a cell." [GO_REF:0000075, GOC:TermGenie, PMID:23895341]
is_a: GO:0043092 ! L-amino acid import
is_a: GO:0090468 ! valine import
created_by: mah
creation_date: 2015-01-16T14:35:23Z

[Term]
id: GO:1903806
name: L-isoleucine import into cell
namespace: biological_process
def: "The directed movement of L-isoleucine into a cell." [GO_REF:0000075, GOC:TermGenie, PMID:23895341]
is_a: GO:0090477 ! L-isoleucine import
created_by: mah
creation_date: 2015-01-16T14:35:33Z

[Term]
id: GO:1903807
name: L-threonine import into cell
namespace: biological_process
def: "The directed movement of L-threonine into a cell." [GO_REF:0000075, GOC:TermGenie, PMID:23895341]
is_a: GO:0036231 ! L-threonine import
created_by: mah
creation_date: 2015-01-16T14:35:42Z

[Term]
id: GO:1903808
name: L-tyrosine import into cell
namespace: biological_process
def: "The directed movement of L-tyrosine into a cell." [GO_REF:0000075, GOC:TermGenie, PMID:23895341]
is_a: GO:0036232 ! L-tyrosine import
created_by: mah
creation_date: 2015-01-16T14:35:51Z

[Term]
id: GO:1903809
name: L-proline import into cell
namespace: biological_process
def: "The directed movement of L-proline into a cell." [GO_REF:0000075, GOC:TermGenie, PMID:23895341]
is_a: GO:0015824 ! proline transport
is_a: GO:0043092 ! L-amino acid import
created_by: mah
creation_date: 2015-01-16T14:36:01Z

[Term]
id: GO:1903810
name: L-histidine import into cell
namespace: biological_process
def: "The directed movement of L-histidine into a cell." [GO_REF:0000075, GOC:TermGenie, PMID:23895341]
is_a: GO:0061460 ! L-histidine import
created_by: mah
creation_date: 2015-01-16T14:36:10Z

[Term]
id: GO:1903811
name: L-asparagine import into cell
namespace: biological_process
def: "The directed movement of L-asparagine into a cell." [GO_REF:0000075, GOC:TermGenie, PMID:23895341]
is_a: GO:0043092 ! L-amino acid import
is_a: GO:0090469 ! asparagine import
created_by: mah
creation_date: 2015-01-16T14:36:19Z

[Term]
id: GO:1903812
name: L-serine import into cell
namespace: biological_process
def: "The directed movement of L-serine into a cell." [GO_REF:0000075, GOC:TermGenie, PMID:23895341]
is_a: GO:0090479 ! L-serine import
created_by: mah
creation_date: 2015-01-16T14:36:29Z

[Term]
id: GO:1903813
name: L-methionine import into cell
namespace: biological_process
def: "The directed movement of L-methionine into a cell." [GO_REF:0000075, GOC:TermGenie, PMID:23895341]
is_a: GO:0043092 ! L-amino acid import
is_a: GO:1903692 ! methionine import into cell
created_by: mah
creation_date: 2015-01-16T15:03:17Z

[Term]
id: GO:1903814
name: regulation of collecting lymphatic vessel constriction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of collecting lymphatic vessel constriction." [GO_REF:0000058, GOC:TermGenie, PMID:23897233]
synonym: "regulation of lymphatic vessel myogenic constriction" EXACT [GOC:TermGenie]
is_a: GO:0044057 ! regulation of system process
is_a: GO:0090066 ! regulation of anatomical structure size
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990192 ! collecting lymphatic vessel constriction
relationship: regulates GO:1990192 ! collecting lymphatic vessel constriction
created_by: sl
creation_date: 2015-01-16T17:01:49Z

[Term]
id: GO:1903815
name: negative regulation of collecting lymphatic vessel constriction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of collecting lymphatic vessel constriction." [GO_REF:0000058, GOC:TermGenie, PMID:23897233]
synonym: "down regulation of collecting lymphatic vessel constriction" EXACT [GOC:TermGenie]
synonym: "down regulation of lymphatic vessel myogenic constriction" EXACT [GOC:TermGenie]
synonym: "down-regulation of collecting lymphatic vessel constriction" EXACT [GOC:TermGenie]
synonym: "down-regulation of lymphatic vessel myogenic constriction" EXACT [GOC:TermGenie]
synonym: "downregulation of collecting lymphatic vessel constriction" EXACT [GOC:TermGenie]
synonym: "downregulation of lymphatic vessel myogenic constriction" EXACT [GOC:TermGenie]
synonym: "inhibition of collecting lymphatic vessel constriction" NARROW [GOC:TermGenie]
synonym: "inhibition of lymphatic vessel myogenic constriction" NARROW [GOC:TermGenie]
synonym: "negative regulation of lymphatic vessel myogenic constriction" EXACT [GOC:TermGenie]
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1903814 ! regulation of collecting lymphatic vessel constriction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990192 ! collecting lymphatic vessel constriction
relationship: negatively_regulates GO:1990192 ! collecting lymphatic vessel constriction
created_by: sl
creation_date: 2015-01-16T17:01:58Z

[Term]
id: GO:1903816
name: positive regulation of collecting lymphatic vessel constriction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of collecting lymphatic vessel constriction." [GO_REF:0000058, GOC:TermGenie, PMID:23897233]
synonym: "activation of collecting lymphatic vessel constriction" NARROW [GOC:TermGenie]
synonym: "activation of lymphatic vessel myogenic constriction" NARROW [GOC:TermGenie]
synonym: "positive regulation of lymphatic vessel myogenic constriction" EXACT [GOC:TermGenie]
synonym: "up regulation of collecting lymphatic vessel constriction" EXACT [GOC:TermGenie]
synonym: "up regulation of lymphatic vessel myogenic constriction" EXACT [GOC:TermGenie]
synonym: "up-regulation of collecting lymphatic vessel constriction" EXACT [GOC:TermGenie]
synonym: "up-regulation of lymphatic vessel myogenic constriction" EXACT [GOC:TermGenie]
synonym: "upregulation of collecting lymphatic vessel constriction" EXACT [GOC:TermGenie]
synonym: "upregulation of lymphatic vessel myogenic constriction" EXACT [GOC:TermGenie]
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1903814 ! regulation of collecting lymphatic vessel constriction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990192 ! collecting lymphatic vessel constriction
relationship: positively_regulates GO:1990192 ! collecting lymphatic vessel constriction
created_by: sl
creation_date: 2015-01-16T17:02:08Z

[Term]
id: GO:1903817
name: negative regulation of voltage-gated potassium channel activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated potassium channel activity." [GO_REF:0000059, GOC:TermGenie, PMID:19219384]
synonym: "down regulation of voltage gated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of voltage-dependent potassium channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of voltage-gated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of voltage-gated potassium ion channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of voltage-sensitive potassium channel" EXACT [GOC:TermGenie]
synonym: "down-regulation of voltage gated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of voltage-dependent potassium channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of voltage-gated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of voltage-gated potassium ion channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of voltage-sensitive potassium channel" EXACT [GOC:TermGenie]
synonym: "downregulation of voltage gated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of voltage-dependent potassium channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of voltage-gated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of voltage-gated potassium ion channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of voltage-sensitive potassium channel" EXACT [GOC:TermGenie]
synonym: "inhibition of voltage gated potassium channel activity" NARROW [GOC:TermGenie]
synonym: "inhibition of voltage-dependent potassium channel activity" NARROW [GOC:TermGenie]
synonym: "inhibition of voltage-gated potassium channel activity" NARROW [GOC:TermGenie]
synonym: "inhibition of voltage-gated potassium ion channel activity" NARROW [GOC:TermGenie]
synonym: "inhibition of voltage-sensitive potassium channel" NARROW [GOC:TermGenie]
synonym: "negative regulation of voltage gated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of voltage-dependent potassium channel activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of voltage-gated potassium ion channel activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of voltage-sensitive potassium channel" EXACT [GOC:TermGenie]
is_a: GO:1901017 ! negative regulation of potassium ion transmembrane transporter activity
is_a: GO:2001258 ! negative regulation of cation channel activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0005249 ! voltage-gated potassium channel activity
relationship: negatively_regulates GO:0005249 ! voltage-gated potassium channel activity
created_by: sl
creation_date: 2015-01-16T17:22:08Z

[Term]
id: GO:1903818
name: positive regulation of voltage-gated potassium channel activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of voltage-gated potassium channel activity." [GO_REF:0000059, GOC:TermGenie, PMID:19219384]
synonym: "activation of voltage gated potassium channel activity" NARROW [GOC:TermGenie]
synonym: "activation of voltage-dependent potassium channel activity" NARROW [GOC:TermGenie]
synonym: "activation of voltage-gated potassium channel activity" NARROW [GOC:TermGenie]
synonym: "activation of voltage-gated potassium ion channel activity" NARROW [GOC:TermGenie]
synonym: "activation of voltage-sensitive potassium channel" NARROW [GOC:TermGenie]
synonym: "positive regulation of voltage gated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of voltage-dependent potassium channel activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of voltage-gated potassium ion channel activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of voltage-sensitive potassium channel" EXACT [GOC:TermGenie]
synonym: "up regulation of voltage gated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of voltage-dependent potassium channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of voltage-gated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of voltage-gated potassium ion channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of voltage-sensitive potassium channel" EXACT [GOC:TermGenie]
synonym: "up-regulation of voltage gated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of voltage-dependent potassium channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of voltage-gated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of voltage-gated potassium ion channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of voltage-sensitive potassium channel" EXACT [GOC:TermGenie]
synonym: "upregulation of voltage gated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of voltage-dependent potassium channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of voltage-gated potassium channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of voltage-gated potassium ion channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of voltage-sensitive potassium channel" EXACT [GOC:TermGenie]
is_a: GO:1901018 ! positive regulation of potassium ion transmembrane transporter activity
is_a: GO:2001259 ! positive regulation of cation channel activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0005249 ! voltage-gated potassium channel activity
relationship: positively_regulates GO:0005249 ! voltage-gated potassium channel activity
created_by: sl
creation_date: 2015-01-16T17:22:18Z

[Term]
id: GO:1903819
name: detection of stimulus involved in mitotic cytokinesis checkpoint
namespace: biological_process
def: "Any detection of stimulus that is involved in a mitotic cytokinesis checkpoint." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "perception of stimulus involved in mitotic cytokinesis checkpoint" RELATED [GOC:TermGenie]
synonym: "stimulus detection involved in mitotic cytokinesis checkpoint" EXACT [GOC:TermGenie]
synonym: "stimulus sensing involved in mitotic cytokinesis checkpoint" RELATED [GOC:TermGenie]
is_a: GO:0072397 ! detection of stimulus involved in cytokinesis checkpoint
is_a: GO:0072412 ! detection of stimulus involved in mitotic cell cycle checkpoint
intersection_of: GO:0051606 ! detection of stimulus
intersection_of: part_of GO:0044878 ! mitotic cytokinesis checkpoint
relationship: part_of GO:0044878 ! mitotic cytokinesis checkpoint
created_by: jl
creation_date: 2015-01-19T15:03:16Z

[Term]
id: GO:1903820
name: signal transduction involved in mitotic cytokinesis checkpoint
namespace: biological_process
def: "Any signal transduction that is involved in a mitotic cytokinesis checkpoint." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "signaling cascade involved in mitotic cytokinesis checkpoint" NARROW [GOC:TermGenie]
synonym: "signaling pathway involved in mitotic cytokinesis checkpoint" RELATED [GOC:TermGenie]
synonym: "signalling cascade involved in mitotic cytokinesis checkpoint" NARROW [GOC:TermGenie]
synonym: "signalling pathway involved in mitotic cytokinesis checkpoint" RELATED [GOC:TermGenie]
is_a: GO:0072398 ! signal transduction involved in cytokinesis checkpoint
is_a: GO:0072413 ! signal transduction involved in mitotic cell cycle checkpoint
intersection_of: GO:0007165 ! signal transduction
intersection_of: part_of GO:0044878 ! mitotic cytokinesis checkpoint
relationship: part_of GO:0044878 ! mitotic cytokinesis checkpoint
created_by: jl
creation_date: 2015-01-19T15:03:50Z

[Term]
id: GO:1903821
name: detection of stimulus involved in morphogenesis checkpoint
namespace: biological_process
def: "Any detection of stimulus that is involved in morphogenesis checkpoint." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "detection of stimulus involved in septin checkpoint" EXACT [GOC:TermGenie]
synonym: "perception of stimulus involved in morphogenesis checkpoint" RELATED [GOC:TermGenie]
synonym: "perception of stimulus involved in septin checkpoint" RELATED [GOC:TermGenie]
synonym: "stimulus detection involved in morphogenesis checkpoint" EXACT [GOC:TermGenie]
synonym: "stimulus detection involved in septin checkpoint" EXACT [GOC:TermGenie]
synonym: "stimulus sensing involved in morphogenesis checkpoint" RELATED [GOC:TermGenie]
synonym: "stimulus sensing involved in septin checkpoint" RELATED [GOC:TermGenie]
is_a: GO:0072412 ! detection of stimulus involved in mitotic cell cycle checkpoint
intersection_of: GO:0051606 ! detection of stimulus
intersection_of: part_of GO:0044879 ! morphogenesis checkpoint
relationship: part_of GO:0044879 ! morphogenesis checkpoint
created_by: jl
creation_date: 2015-01-19T15:03:59Z

[Term]
id: GO:1903822
name: signal transduction involved in morphogenesis checkpoint
namespace: biological_process
def: "Any signal transduction that is involved in morphogenesis checkpoint." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie]
synonym: "signal transduction involved in septin checkpoint" EXACT [GOC:TermGenie]
synonym: "signaling cascade involved in morphogenesis checkpoint" NARROW [GOC:TermGenie]
synonym: "signaling cascade involved in septin checkpoint" NARROW [GOC:TermGenie]
synonym: "signaling pathway involved in morphogenesis checkpoint" RELATED [GOC:TermGenie]
synonym: "signaling pathway involved in septin checkpoint" RELATED [GOC:TermGenie]
synonym: "signalling cascade involved in morphogenesis checkpoint" NARROW [GOC:TermGenie]
synonym: "signalling cascade involved in septin checkpoint" NARROW [GOC:TermGenie]
synonym: "signalling pathway involved in morphogenesis checkpoint" RELATED [GOC:TermGenie]
synonym: "signalling pathway involved in septin checkpoint" RELATED [GOC:TermGenie]
is_a: GO:0007165 ! signal transduction
intersection_of: GO:0007165 ! signal transduction
intersection_of: part_of GO:0044879 ! morphogenesis checkpoint
relationship: part_of GO:0044879 ! morphogenesis checkpoint
created_by: jl
creation_date: 2015-01-19T15:04:08Z

[Term]
id: GO:1903823
name: telomere single strand break repair
namespace: biological_process
def: "Single strand break repair that takes place in a telomere." [GO_REF:0000062, GOC:TermGenie, PMID:24374808]
synonym: "single strand break repair in telomere" EXACT [GOC:TermGenie]
synonym: "telomere single-strand break repair" EXACT []
synonym: "telomere SSBR" RELATED []
synonym: "telomeric single strand break repair" EXACT []
is_a: GO:0000012 ! single strand break repair
intersection_of: GO:0000012 ! single strand break repair
intersection_of: occurs_in GO:0000781 ! chromosome, telomeric region
relationship: occurs_in GO:0000781 ! chromosome, telomeric region
created_by: jl
creation_date: 2015-01-19T16:12:29Z

[Term]
id: GO:1903824
name: negative regulation of telomere single strand break repair
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of telomere single strand break repair." [GO_REF:0000058, GOC:TermGenie, PMID:24374808]
synonym: "down regulation of single strand break repair in telomere" EXACT [GOC:TermGenie]
synonym: "down regulation of telomere single strand break repair" EXACT [GOC:TermGenie]
synonym: "down regulation of telomere single-strand break repair" EXACT [GOC:TermGenie]
synonym: "down regulation of telomere SSBR" RELATED [GOC:TermGenie]
synonym: "down regulation of telomeric single strand break repair" EXACT [GOC:TermGenie]
synonym: "down-regulation of single strand break repair in telomere" EXACT [GOC:TermGenie]
synonym: "down-regulation of telomere single strand break repair" EXACT [GOC:TermGenie]
synonym: "down-regulation of telomere single-strand break repair" EXACT [GOC:TermGenie]
synonym: "down-regulation of telomere SSBR" RELATED [GOC:TermGenie]
synonym: "down-regulation of telomeric single strand break repair" EXACT [GOC:TermGenie]
synonym: "downregulation of single strand break repair in telomere" EXACT [GOC:TermGenie]
synonym: "downregulation of telomere single strand break repair" EXACT [GOC:TermGenie]
synonym: "downregulation of telomere single-strand break repair" EXACT [GOC:TermGenie]
synonym: "downregulation of telomere SSBR" RELATED [GOC:TermGenie]
synonym: "downregulation of telomeric single strand break repair" EXACT [GOC:TermGenie]
synonym: "inhibition of single strand break repair in telomere" NARROW [GOC:TermGenie]
synonym: "inhibition of telomere single strand break repair" NARROW [GOC:TermGenie]
synonym: "inhibition of telomere single-strand break repair" NARROW [GOC:TermGenie]
synonym: "inhibition of telomere SSBR" RELATED [GOC:TermGenie]
synonym: "inhibition of telomeric single strand break repair" NARROW [GOC:TermGenie]
synonym: "negative regulation of single strand break repair in telomere" EXACT [GOC:TermGenie]
synonym: "negative regulation of telomere single-strand break repair" EXACT [GOC:TermGenie]
synonym: "negative regulation of telomere SSBR" RELATED [GOC:TermGenie]
synonym: "negative regulation of telomeric single strand break repair" EXACT [GOC:TermGenie]
is_a: GO:1903517 ! negative regulation of single strand break repair
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1903823 ! telomere single strand break repair
relationship: negatively_regulates GO:1903823 ! telomere single strand break repair
created_by: jl
creation_date: 2015-01-19T16:24:37Z

[Term]
id: GO:1903825
name: organic acid transmembrane transport
namespace: biological_process
def: "The directed movement of organic acid across a membrane." [GO_REF:0000069, GOC:TermGenie]
is_a: GO:0015849 ! organic acid transport
is_a: GO:0055085 ! transmembrane transport
created_by: vw
creation_date: 2015-01-20T10:20:58Z

[Term]
id: GO:1903826
name: arginine transmembrane transport
namespace: biological_process
def: "The directed movement of arginine across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:18357653]
is_a: GO:0003333 ! amino acid transmembrane transport
is_a: GO:0015809 ! arginine transport
is_a: GO:0098655 ! cation transmembrane transport
created_by: vw
creation_date: 2015-01-20T10:38:15Z

[Term]
id: GO:1903827
name: regulation of cellular protein localization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular protein localization. Cellular protein localization is any process in which a protein is transported to, and/or maintained in, a specific location and encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "regulation of cellular protein localisation" EXACT [GOC:TermGenie]
synonym: "regulation of channel localizer activity" NARROW [GOC:TermGenie]
is_a: GO:0032880 ! regulation of protein localization
is_a: GO:0060341 ! regulation of cellular localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034613 ! cellular protein localization
relationship: regulates GO:0034613 ! cellular protein localization
created_by: jl
creation_date: 2015-01-20T14:32:14Z

[Term]
id: GO:1903828
name: negative regulation of cellular protein localization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular protein localization. Cellular protein localization is any process in which a protein is transported to, and/or maintained in, a specific location and encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "down regulation of cellular protein localisation" EXACT [GOC:TermGenie]
synonym: "down regulation of cellular protein localization" EXACT [GOC:TermGenie]
synonym: "down regulation of channel localizer activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of cellular protein localisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular protein localization" EXACT [GOC:TermGenie]
synonym: "down-regulation of channel localizer activity" NARROW [GOC:TermGenie]
synonym: "downregulation of cellular protein localisation" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular protein localization" EXACT [GOC:TermGenie]
synonym: "downregulation of channel localizer activity" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular protein localisation" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular protein localization" NARROW [GOC:TermGenie]
synonym: "inhibition of channel localizer activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of cellular protein localisation" EXACT [GOC:TermGenie]
synonym: "negative regulation of channel localizer activity" NARROW [GOC:TermGenie]
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:1903827 ! regulation of cellular protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034613 ! cellular protein localization
relationship: negatively_regulates GO:0034613 ! cellular protein localization
created_by: jl
creation_date: 2015-01-20T14:32:24Z

[Term]
id: GO:1903829
name: positive regulation of cellular protein localization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellular protein localization. Cellular protein localization is any process in which a protein is transported to, and/or maintained in, a specific location and encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "activation of cellular protein localisation" NARROW [GOC:TermGenie]
synonym: "activation of cellular protein localization" NARROW [GOC:TermGenie]
synonym: "activation of channel localizer activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of cellular protein localisation" EXACT [GOC:TermGenie]
synonym: "positive regulation of channel localizer activity" NARROW [GOC:TermGenie]
synonym: "up regulation of cellular protein localisation" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular protein localization" EXACT [GOC:TermGenie]
synonym: "up regulation of channel localizer activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of cellular protein localisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular protein localization" EXACT [GOC:TermGenie]
synonym: "up-regulation of channel localizer activity" NARROW [GOC:TermGenie]
synonym: "upregulation of cellular protein localisation" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular protein localization" EXACT [GOC:TermGenie]
synonym: "upregulation of channel localizer activity" NARROW [GOC:TermGenie]
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:1903827 ! regulation of cellular protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034613 ! cellular protein localization
relationship: positively_regulates GO:0034613 ! cellular protein localization
created_by: jl
creation_date: 2015-01-20T14:32:33Z

[Term]
id: GO:1903830
name: magnesium ion transmembrane transport
namespace: biological_process
def: "The directed movement of magnesium ion across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:11254124]
is_a: GO:0055085 ! transmembrane transport
created_by: mcc
creation_date: 2015-01-21T17:38:30Z

[Term]
id: GO:1903831
name: signal transduction involved in cellular response to ammonium ion
namespace: biological_process
def: "Any signal transduction that is involved in cellular response to ammonium ion." [GO_REF:0000060, GOC:TermGenie, PMID:16297994]
synonym: "signaling cascade involved in cellular response to ammonium ion" NARROW [GOC:TermGenie]
synonym: "signaling pathway involved in cellular response to ammonium ion" RELATED [GOC:TermGenie]
synonym: "signalling cascade involved in cellular response to ammonium ion" NARROW [GOC:TermGenie]
synonym: "signalling pathway involved in cellular response to ammonium ion" RELATED [GOC:TermGenie]
is_a: GO:0007165 ! signal transduction
intersection_of: GO:0007165 ! signal transduction
intersection_of: part_of GO:0071242 ! cellular response to ammonium ion
relationship: part_of GO:0071242 ! cellular response to ammonium ion
created_by: al
creation_date: 2015-01-21T17:52:09Z

[Term]
id: GO:1903832
name: regulation of cellular response to amino acid starvation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular response to amino acid starvation." [GO_REF:0000058, GOC:TermGenie, PMID:25002487, PMID:7623840]
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0032107 ! regulation of response to nutrient levels
is_a: GO:0080135 ! regulation of cellular response to stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034198 ! cellular response to amino acid starvation
relationship: regulates GO:0034198 ! cellular response to amino acid starvation
created_by: rn
creation_date: 2015-01-21T18:44:28Z

[Term]
id: GO:1903833
name: positive regulation of cellular response to amino acid starvation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellular response to amino acid starvation." [GO_REF:0000058, GOC:TermGenie, PMID:25002487, PMID:7623840]
synonym: "activation of cellular response to amino acid starvation" NARROW [GOC:TermGenie]
synonym: "up regulation of cellular response to amino acid starvation" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular response to amino acid starvation" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular response to amino acid starvation" EXACT [GOC:TermGenie]
is_a: GO:0010647 ! positive regulation of cell communication
is_a: GO:0032109 ! positive regulation of response to nutrient levels
is_a: GO:1903832 ! regulation of cellular response to amino acid starvation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034198 ! cellular response to amino acid starvation
relationship: positively_regulates GO:0034198 ! cellular response to amino acid starvation
created_by: rn
creation_date: 2015-01-21T18:44:37Z

[Term]
id: GO:1903834
name: regulation of APC-fizzy related complex activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of APC-fizzy related complex activity." [GO_REF:0000059, GOC:TermGenie, GOC:vw, PMID:10921876]
is_a: GO:0007096 ! regulation of exit from mitosis
is_a: GO:1904666 ! regulation of ubiquitin protein ligase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0090622 ! APC-fizzy related complex activity
relationship: regulates GO:0090622 ! APC-fizzy related complex activity
created_by: tb
creation_date: 2015-01-22T00:12:00Z

[Term]
id: GO:1903835
name: positive regulation of APC-fizzy related complex activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of APC-fizzy related complex activity." [GO_REF:0000059, GOC:TermGenie, GOC:vw, PMID:10921876]
synonym: "up regulation of APC-fizzy related complex activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of APC-fizzy related complex activity" EXACT [GOC:TermGenie]
synonym: "upregulation of APC-fizzy related complex activity" EXACT [GOC:TermGenie]
is_a: GO:1903834 ! regulation of APC-fizzy related complex activity
is_a: GO:1904668 ! positive regulation of ubiquitin protein ligase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0090622 ! APC-fizzy related complex activity
relationship: positively_regulates GO:0090622 ! APC-fizzy related complex activity
created_by: tb
creation_date: 2015-01-22T00:12:10Z

[Term]
id: GO:1903837
name: regulation of mRNA 3'-UTR binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mRNA 3'-UTR binding." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:19575011]
synonym: "regulation of mRNA 3' UTR binding" EXACT [GOC:TermGenie]
is_a: GO:1902415 ! regulation of mRNA binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003730 ! mRNA 3'-UTR binding
relationship: regulates GO:0003730 ! mRNA 3'-UTR binding
created_by: als
creation_date: 2015-01-22T11:53:59Z

[Term]
id: GO:1903838
name: negative regulation of mRNA 3'-UTR binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA 3'-UTR binding." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:19575011]
synonym: "down regulation of mRNA 3' UTR binding" EXACT [GOC:TermGenie]
synonym: "down regulation of mRNA 3'-UTR binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of mRNA 3' UTR binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of mRNA 3'-UTR binding" EXACT [GOC:TermGenie]
synonym: "downregulation of mRNA 3' UTR binding" EXACT [GOC:TermGenie]
synonym: "downregulation of mRNA 3'-UTR binding" EXACT [GOC:TermGenie]
synonym: "inhibition of mRNA 3' UTR binding" NARROW [GOC:TermGenie]
synonym: "inhibition of mRNA 3'-UTR binding" NARROW [GOC:TermGenie]
synonym: "negative regulation of mRNA 3' UTR binding" EXACT [GOC:TermGenie]
is_a: GO:1903837 ! regulation of mRNA 3'-UTR binding
is_a: GO:1904572 ! negative regulation of mRNA binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003730 ! mRNA 3'-UTR binding
relationship: negatively_regulates GO:0003730 ! mRNA 3'-UTR binding
created_by: als
creation_date: 2015-01-22T11:54:08Z

[Term]
id: GO:1903839
name: positive regulation of mRNA 3'-UTR binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mRNA 3'-UTR binding." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:19575011]
synonym: "activation of mRNA 3' UTR binding" NARROW [GOC:TermGenie]
synonym: "activation of mRNA 3'-UTR binding" NARROW [GOC:TermGenie]
synonym: "positive regulation of mRNA 3' UTR binding" EXACT [GOC:TermGenie]
synonym: "up regulation of mRNA 3' UTR binding" EXACT [GOC:TermGenie]
synonym: "up regulation of mRNA 3'-UTR binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of mRNA 3' UTR binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of mRNA 3'-UTR binding" EXACT [GOC:TermGenie]
synonym: "upregulation of mRNA 3' UTR binding" EXACT [GOC:TermGenie]
synonym: "upregulation of mRNA 3'-UTR binding" EXACT [GOC:TermGenie]
is_a: GO:1902416 ! positive regulation of mRNA binding
is_a: GO:1903837 ! regulation of mRNA 3'-UTR binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003730 ! mRNA 3'-UTR binding
relationship: positively_regulates GO:0003730 ! mRNA 3'-UTR binding
created_by: als
creation_date: 2015-01-22T11:54:17Z

[Term]
id: GO:1903840
name: response to arsenite(3-)
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenite(3-) stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:12106899]
is_a: GO:0001101 ! response to acid chemical
is_a: GO:1903842 ! response to arsenite ion
created_by: mr
creation_date: 2015-01-22T19:49:25Z

[Term]
id: GO:1903841
name: cellular response to arsenite(3-)
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenite(3-) stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:12106899]
is_a: GO:0071229 ! cellular response to acid chemical
is_a: GO:1903840 ! response to arsenite(3-)
is_a: GO:1903843 ! cellular response to arsenite ion
created_by: mr
creation_date: 2015-01-22T19:49:35Z

[Term]
id: GO:1903842
name: response to arsenite ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenite ion stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:12106899]
is_a: GO:0010035 ! response to inorganic substance
is_a: GO:0046685 ! response to arsenic-containing substance
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: mr
creation_date: 2015-01-22T19:56:05Z

[Term]
id: GO:1903843
name: cellular response to arsenite ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenite ion stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:12106899]
is_a: GO:0071243 ! cellular response to arsenic-containing substance
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1903842 ! response to arsenite ion
created_by: mr
creation_date: 2015-01-22T19:56:14Z

[Term]
id: GO:1903844
name: regulation of cellular response to transforming growth factor beta stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular response to transforming growth factor beta stimulus." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326]
synonym: "regulation of cellular response to TGF-beta stimulus" EXACT [GOC:TermGenie]
synonym: "regulation of cellular response to TGFbeta stimulus" EXACT [GOC:TermGenie]
is_a: GO:0090287 ! regulation of cellular response to growth factor stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071560 ! cellular response to transforming growth factor beta stimulus
relationship: regulates GO:0071560 ! cellular response to transforming growth factor beta stimulus
created_by: rph
creation_date: 2015-01-23T11:25:11Z

[Term]
id: GO:1903845
name: negative regulation of cellular response to transforming growth factor beta stimulus
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to transforming growth factor beta stimulus." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326]
synonym: "down regulation of cellular response to TGF-beta stimulus" EXACT [GOC:TermGenie]
synonym: "down regulation of cellular response to TGFbeta stimulus" EXACT [GOC:TermGenie]
synonym: "down regulation of cellular response to transforming growth factor beta stimulus" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular response to TGF-beta stimulus" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular response to TGFbeta stimulus" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular response to transforming growth factor beta stimulus" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular response to TGF-beta stimulus" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular response to TGFbeta stimulus" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular response to transforming growth factor beta stimulus" EXACT [GOC:TermGenie]
synonym: "inhibition of cellular response to TGF-beta stimulus" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular response to TGFbeta stimulus" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular response to transforming growth factor beta stimulus" NARROW [GOC:TermGenie]
synonym: "negative regulation of cellular response to TGF-beta stimulus" EXACT [GOC:TermGenie]
synonym: "negative regulation of cellular response to TGFbeta stimulus" EXACT [GOC:TermGenie]
is_a: GO:0090288 ! negative regulation of cellular response to growth factor stimulus
is_a: GO:1903844 ! regulation of cellular response to transforming growth factor beta stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071560 ! cellular response to transforming growth factor beta stimulus
relationship: negatively_regulates GO:0071560 ! cellular response to transforming growth factor beta stimulus
created_by: rph
creation_date: 2015-01-23T11:25:21Z

[Term]
id: GO:1903846
name: positive regulation of cellular response to transforming growth factor beta stimulus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellular response to transforming growth factor beta stimulus." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326]
synonym: "activation of cellular response to TGF-beta stimulus" NARROW [GOC:TermGenie]
synonym: "activation of cellular response to TGFbeta stimulus" NARROW [GOC:TermGenie]
synonym: "activation of cellular response to transforming growth factor beta stimulus" NARROW [GOC:TermGenie]
synonym: "positive regulation of cellular response to TGF-beta stimulus" EXACT [GOC:TermGenie]
synonym: "positive regulation of cellular response to TGFbeta stimulus" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular response to TGF-beta stimulus" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular response to TGFbeta stimulus" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular response to transforming growth factor beta stimulus" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular response to TGF-beta stimulus" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular response to TGFbeta stimulus" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular response to transforming growth factor beta stimulus" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular response to TGF-beta stimulus" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular response to TGFbeta stimulus" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular response to transforming growth factor beta stimulus" EXACT [GOC:TermGenie]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1903844 ! regulation of cellular response to transforming growth factor beta stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071560 ! cellular response to transforming growth factor beta stimulus
relationship: positively_regulates GO:0071560 ! cellular response to transforming growth factor beta stimulus
created_by: rph
creation_date: 2015-01-23T11:25:30Z

[Term]
id: GO:1903847
name: regulation of aorta morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of aorta morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:1901342 ! regulation of vasculature development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035909 ! aorta morphogenesis
relationship: regulates GO:0035909 ! aorta morphogenesis
created_by: rph
creation_date: 2015-01-23T14:00:51Z

[Term]
id: GO:1903848
name: negative regulation of aorta morphogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of aorta morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326]
synonym: "down regulation of aorta morphogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of aorta morphogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of aorta morphogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of aorta morphogenesis" NARROW [GOC:TermGenie]
is_a: GO:1903847 ! regulation of aorta morphogenesis
is_a: GO:2000181 ! negative regulation of blood vessel morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035909 ! aorta morphogenesis
relationship: negatively_regulates GO:0035909 ! aorta morphogenesis
created_by: rph
creation_date: 2015-01-23T14:01:01Z

[Term]
id: GO:1903849
name: positive regulation of aorta morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of aorta morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326]
synonym: "activation of aorta morphogenesis" NARROW [GOC:TermGenie]
synonym: "up regulation of aorta morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of aorta morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of aorta morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:1903847 ! regulation of aorta morphogenesis
is_a: GO:1904018 ! positive regulation of vasculature development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035909 ! aorta morphogenesis
relationship: positively_regulates GO:0035909 ! aorta morphogenesis
created_by: rph
creation_date: 2015-01-23T14:01:09Z

[Term]
id: GO:1903850
name: regulation of cristae formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cristae formation." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:19279012]
comment: AN example of this is PINK1 in human (Q9BXM7) in PMID:19279012 inferred from mutant phenotype
is_a: GO:0010821 ! regulation of mitochondrion organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042407 ! cristae formation
relationship: regulates GO:0042407 ! cristae formation
created_by: pad
creation_date: 2015-01-27T09:42:23Z

[Term]
id: GO:1903851
name: negative regulation of cristae formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cristae formation." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:19279012]
comment: AN example of this is PINK1 in human (Q9BXM7) in PMID:19279012 inferred from mutant phenotype
synonym: "down regulation of cristae formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of cristae formation" EXACT [GOC:TermGenie]
synonym: "downregulation of cristae formation" EXACT [GOC:TermGenie]
synonym: "inhibition of cristae formation" NARROW [GOC:TermGenie]
is_a: GO:0010823 ! negative regulation of mitochondrion organization
is_a: GO:1903850 ! regulation of cristae formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042407 ! cristae formation
relationship: negatively_regulates GO:0042407 ! cristae formation
created_by: pad
creation_date: 2015-01-27T09:42:33Z

[Term]
id: GO:1903852
name: positive regulation of cristae formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cristae formation." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:19279012]
comment: AN example of this is PINK1 in human (Q9BXM7) in PMID:19279012 inferred from mutant phenotype
synonym: "activation of cristae formation" NARROW [GOC:TermGenie]
synonym: "up regulation of cristae formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of cristae formation" EXACT [GOC:TermGenie]
synonym: "upregulation of cristae formation" EXACT [GOC:TermGenie]
is_a: GO:0010822 ! positive regulation of mitochondrion organization
is_a: GO:1903850 ! regulation of cristae formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042407 ! cristae formation
relationship: positively_regulates GO:0042407 ! cristae formation
created_by: pad
creation_date: 2015-01-27T09:42:42Z

[Term]
id: GO:1903853
name: regulation of stress response to copper ion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of stress response to copper ion." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:23437011]
synonym: "regulation of response to copper ion stress" EXACT [GOC:TermGenie]
synonym: "regulation of response to copper toxicity" RELATED [GOC:TermGenie]
synonym: "regulation of stress response to copper" BROAD [GOC:TermGenie]
is_a: GO:0080134 ! regulation of response to stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990169 ! stress response to copper ion
relationship: regulates GO:1990169 ! stress response to copper ion
created_by: kmv
creation_date: 2015-01-29T20:15:23Z

[Term]
id: GO:1903854
name: negative regulation of stress response to copper ion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of stress response to copper ion." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:23437011]
synonym: "down regulation of response to copper ion stress" EXACT [GOC:TermGenie]
synonym: "down regulation of response to copper toxicity" RELATED [GOC:TermGenie]
synonym: "down regulation of stress response to copper ion" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to copper ion stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to copper toxicity" RELATED [GOC:TermGenie]
synonym: "down-regulation of stress response to copper ion" EXACT [GOC:TermGenie]
synonym: "downregulation of response to copper ion stress" EXACT [GOC:TermGenie]
synonym: "downregulation of response to copper toxicity" RELATED [GOC:TermGenie]
synonym: "downregulation of stress response to copper ion" EXACT [GOC:TermGenie]
synonym: "inhibition of response to copper ion stress" NARROW [GOC:TermGenie]
synonym: "inhibition of response to copper toxicity" RELATED [GOC:TermGenie]
synonym: "inhibition of stress response to copper ion" NARROW [GOC:TermGenie]
synonym: "negative regulation of response to copper ion stress" EXACT [GOC:TermGenie]
synonym: "negative regulation of response to copper toxicity" RELATED [GOC:TermGenie]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1903853 ! regulation of stress response to copper ion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990169 ! stress response to copper ion
relationship: negatively_regulates GO:1990169 ! stress response to copper ion
created_by: kmv
creation_date: 2015-01-29T20:15:33Z

[Term]
id: GO:1903855
name: positive regulation of stress response to copper ion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of stress response to copper ion." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:23437011]
synonym: "activation of response to copper ion stress" NARROW [GOC:TermGenie]
synonym: "activation of response to copper toxicity" RELATED [GOC:TermGenie]
synonym: "activation of stress response to copper ion" NARROW [GOC:TermGenie]
synonym: "positive regulation of response to copper ion stress" EXACT [GOC:TermGenie]
synonym: "positive regulation of response to copper toxicity" RELATED [GOC:TermGenie]
synonym: "up regulation of response to copper ion stress" EXACT [GOC:TermGenie]
synonym: "up regulation of response to copper toxicity" RELATED [GOC:TermGenie]
synonym: "up regulation of stress response to copper ion" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to copper ion stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to copper toxicity" RELATED [GOC:TermGenie]
synonym: "up-regulation of stress response to copper ion" EXACT [GOC:TermGenie]
synonym: "upregulation of response to copper ion stress" EXACT [GOC:TermGenie]
synonym: "upregulation of response to copper toxicity" RELATED [GOC:TermGenie]
synonym: "upregulation of stress response to copper ion" EXACT [GOC:TermGenie]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1903853 ! regulation of stress response to copper ion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990169 ! stress response to copper ion
relationship: positively_regulates GO:1990169 ! stress response to copper ion
created_by: kmv
creation_date: 2015-01-29T20:15:42Z

[Term]
id: GO:1903856
name: regulation of cytokinin dehydrogenase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cytokinin dehydrogenase activity." [GO_REF:0000059, GOC:TermGenie, PMID:25535363]
synonym: "regulation of 6-N-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of cytokinin oxidase activity" RELATED [GOC:TermGenie]
synonym: "regulation of N6-dimethylallyladenine:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of N6-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [GOC:TermGenie]
is_a: GO:0051341 ! regulation of oxidoreductase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019139 ! cytokinin dehydrogenase activity
relationship: regulates GO:0019139 ! cytokinin dehydrogenase activity
created_by: tb
creation_date: 2015-01-30T00:33:51Z

[Term]
id: GO:1903857
name: negative regulation of cytokinin dehydrogenase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytokinin dehydrogenase activity." [GO_REF:0000059, GOC:TermGenie, PMID:25535363]
synonym: "down regulation of 6-N-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of cytokinin dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of cytokinin oxidase activity" RELATED [GOC:TermGenie]
synonym: "down regulation of N6-dimethylallyladenine:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of N6-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of 6-N-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of cytokinin dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of cytokinin oxidase activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of N6-dimethylallyladenine:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of N6-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of 6-N-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of cytokinin dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of cytokinin oxidase activity" RELATED [GOC:TermGenie]
synonym: "downregulation of N6-dimethylallyladenine:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of N6-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of 6-N-dimethylallyladenine:acceptor oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of cytokinin dehydrogenase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of cytokinin oxidase activity" RELATED [GOC:TermGenie]
synonym: "inhibition of N6-dimethylallyladenine:(acceptor) oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of N6-dimethylallyladenine:acceptor oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of 6-N-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of cytokinin oxidase activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of N6-dimethylallyladenine:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of N6-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [GOC:TermGenie]
is_a: GO:0051354 ! negative regulation of oxidoreductase activity
is_a: GO:1903856 ! regulation of cytokinin dehydrogenase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019139 ! cytokinin dehydrogenase activity
relationship: negatively_regulates GO:0019139 ! cytokinin dehydrogenase activity
created_by: tb
creation_date: 2015-01-30T00:34:01Z

[Term]
id: GO:1903858
name: protein localization to old growing cell tip
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within an old growing cell tip." [GO_REF:0000087, GOC:TermGenie, PMID:17895368]
synonym: "protein localisation in old growing cell tip" EXACT [GOC:TermGenie]
synonym: "protein localisation to old growing cell tip" EXACT [GOC:TermGenie]
synonym: "protein localization in old growing cell tip" EXACT [GOC:TermGenie]
is_a: GO:1902486 ! protein localization to growing cell tip
created_by: mah
creation_date: 2015-02-02T13:53:29Z

[Term]
id: GO:1903859
name: regulation of dendrite extension
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dendrite extension." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:24898855]
comment: An example of this is Mul1 in mouse (UniProt ID Q8VCM5) in PMID:24898855 inferred from mutant phenotype.
is_a: GO:0001558 ! regulation of cell growth
is_a: GO:0010975 ! regulation of neuron projection development
is_a: GO:0022604 ! regulation of cell morphogenesis
is_a: GO:0048638 ! regulation of developmental growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097484 ! dendrite extension
relationship: regulates GO:0097484 ! dendrite extension
created_by: pad
creation_date: 2015-02-02T15:33:51Z

[Term]
id: GO:1903860
name: negative regulation of dendrite extension
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of dendrite extension." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:24898855]
comment: An example of this is Mul1 in mouse (UniProt ID Q8VCM5) in PMID:24898855 inferred from mutant phenotype.
synonym: "down regulation of dendrite extension" EXACT [GOC:TermGenie]
synonym: "down-regulation of dendrite extension" EXACT [GOC:TermGenie]
synonym: "downregulation of dendrite extension" EXACT [GOC:TermGenie]
synonym: "inhibition of dendrite extension" NARROW [GOC:TermGenie]
synonym: "up regulation of dendrite retraction" EXACT [GOC:pad]
synonym: "up-regulation of dendrite retraction" EXACT [GOC:pad]
is_a: GO:0010977 ! negative regulation of neuron projection development
is_a: GO:0030308 ! negative regulation of cell growth
is_a: GO:0048640 ! negative regulation of developmental growth
is_a: GO:1903859 ! regulation of dendrite extension
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097484 ! dendrite extension
relationship: negatively_regulates GO:0097484 ! dendrite extension
created_by: pad
creation_date: 2015-02-02T15:34:00Z

[Term]
id: GO:1903861
name: positive regulation of dendrite extension
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of dendrite extension." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:24898855]
comment: An example of this is Mul1 in mouse (UniProt ID Q8VCM5) in PMID:24898855 inferred from mutant phenotype.
synonym: "activation of dendrite extension" NARROW [GOC:TermGenie]
synonym: "up regulation of dendrite extension" EXACT [GOC:TermGenie]
synonym: "up-regulation of dendrite extension" EXACT [GOC:TermGenie]
synonym: "upregulation of dendrite extension" EXACT [GOC:TermGenie]
is_a: GO:0010976 ! positive regulation of neuron projection development
is_a: GO:0030307 ! positive regulation of cell growth
is_a: GO:0048639 ! positive regulation of developmental growth
is_a: GO:1903859 ! regulation of dendrite extension
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097484 ! dendrite extension
relationship: positively_regulates GO:0097484 ! dendrite extension
created_by: pad
creation_date: 2015-02-02T15:34:09Z

[Term]
id: GO:1903862
name: positive regulation of oxidative phosphorylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of oxidative phosphorylation." [GO_REF:0000058, GOC:TermGenie, PMID:10225962]
synonym: "activation of oxidative phosphorylation" NARROW [GOC:TermGenie]
synonym: "activation of respiratory-chain phosphorylation" NARROW [GOC:TermGenie]
synonym: "positive regulation of respiratory-chain phosphorylation" EXACT [GOC:TermGenie]
synonym: "up regulation of oxidative phosphorylation" EXACT [GOC:TermGenie]
synonym: "up regulation of respiratory-chain phosphorylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of oxidative phosphorylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of respiratory-chain phosphorylation" EXACT [GOC:TermGenie]
synonym: "upregulation of oxidative phosphorylation" EXACT [GOC:TermGenie]
synonym: "upregulation of respiratory-chain phosphorylation" EXACT [GOC:TermGenie]
is_a: GO:0002082 ! regulation of oxidative phosphorylation
is_a: GO:0042327 ! positive regulation of phosphorylation
is_a: GO:1903580 ! positive regulation of ATP metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006119 ! oxidative phosphorylation
relationship: positively_regulates GO:0006119 ! oxidative phosphorylation
created_by: sl
creation_date: 2015-02-02T23:40:22Z

[Term]
id: GO:1903863
name: P granule assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a P granule." [GO_REF:0000079, GOC:kmv, GOC:TermGenie, PMID:25535836]
synonym: "germline granule assembly" EXACT [GOC:TermGenie]
synonym: "germline granule formation" EXACT [GOC:TermGenie]
synonym: "P granule formation" EXACT [GOC:TermGenie]
synonym: "polar granule assembly" EXACT [GOC:TermGenie]
synonym: "polar granule formation" EXACT [GOC:TermGenie]
is_a: GO:0022618 ! ribonucleoprotein complex assembly
is_a: GO:0030719 ! P granule organization
is_a: GO:0070925 ! organelle assembly
created_by: kmv
creation_date: 2015-02-04T15:27:02Z

[Term]
id: GO:1903864
name: P granule disassembly
namespace: biological_process
def: "The disaggregation of a P granule into its constituent components." [GO_REF:0000079, GOC:kmv, GOC:TermGenie, PMID:25535836]
synonym: "germline granule disassembly" EXACT [GOC:TermGenie]
synonym: "polar granule disassembly" EXACT [GOC:TermGenie]
is_a: GO:0030719 ! P granule organization
is_a: GO:0032988 ! ribonucleoprotein complex disassembly
is_a: GO:1903008 ! organelle disassembly
created_by: kmv
creation_date: 2015-02-04T15:27:12Z

[Term]
id: GO:1903865
name: sigma factor antagonist complex
namespace: cellular_component
def: "A protein complex which is capable of sigma factor antagonist activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:23687042]
is_a: GO:0043234 ! protein complex
created_by: bhm
creation_date: 2015-02-04T15:39:34Z

[Term]
id: GO:1903866
name: palisade mesophyll development
namespace: biological_process
def: "The process whose specific outcome is the progression of a palisade mesophyll over time, from its formation to the mature structure." [GO_REF:0000080, GOC:TermGenie, PMID:24663344]
synonym: "palisade parenchyma development" RELATED [GOC:TermGenie]
is_a: GO:0048856 ! anatomical structure development
created_by: tb
creation_date: 2015-02-04T21:51:44Z

[Term]
id: GO:1903867
name: extraembryonic membrane development
namespace: biological_process
def: "The process whose specific outcome is the progression of an extraembryonic membrane over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, ISBN:0073040584]
is_a: GO:0048856 ! anatomical structure development
created_by: cjm
creation_date: 2015-02-05T00:42:16Z

[Term]
id: GO:1903868
name: regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of methylenetetrahydrofolate reductase (NAD(P)H) activity." [GO_REF:0000059, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:24769206]
synonym: "regulation of 1.7.99.5" RELATED [GOC:TermGenie]
synonym: "regulation of 5,10-CH(2)-H(4)folate reductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of 5,10-CH2-H4folate reductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [GOC:TermGenie]
synonym: "regulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity" EXACT [GOC:TermGenie]
synonym: "regulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity" EXACT [GOC:TermGenie]
synonym: "regulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity" EXACT [GOC:TermGenie]
synonym: "regulation of 5,10-methylenetetrahydrofolate reductase activity" BROAD [GOC:TermGenie]
synonym: "regulation of 5,10-methylenetetrahydrofolic acid reductase activity" BROAD [GOC:TermGenie]
synonym: "regulation of 5,10-methylenetetrahydropteroylglutamate reductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of MetF" RELATED [GOC:TermGenie]
synonym: "regulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [GOC:TermGenie]
synonym: "regulation of methylenetetrahydrofolate reductase (NADPH(2)) activity" EXACT [GOC:TermGenie]
synonym: "regulation of methylenetetrahydrofolate reductase (NADPH2)" EXACT [GOC:TermGenie]
synonym: "regulation of methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [GOC:TermGenie]
synonym: "regulation of methylenetetrahydrofolate reductase activity" BROAD [GOC:TermGenie]
synonym: "regulation of methylenetetrahydrofolic acid reductase activity" BROAD [GOC:TermGenie]
synonym: "regulation of MTHFR activity" BROAD [GOC:TermGenie]
synonym: "regulation of N(5),N(10)-methylenetetrahydrofolate reductase activity" BROAD [GOC:TermGenie]
synonym: "regulation of N(5,10)-methylenetetrahydrofolate reductase activity" BROAD [GOC:TermGenie]
synonym: "regulation of N5,10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of N5,N10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie]
is_a: GO:0051341 ! regulation of oxidoreductase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004489 ! methylenetetrahydrofolate reductase (NAD(P)H) activity
relationship: regulates GO:0004489 ! methylenetetrahydrofolate reductase (NAD(P)H) activity
created_by: rph
creation_date: 2015-02-05T13:26:14Z

[Term]
id: GO:1903869
name: negative regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of methylenetetrahydrofolate reductase (NAD(P)H) activity." [GO_REF:0000059, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:24769206]
synonym: "down regulation of 1.7.99.5" RELATED [GOC:TermGenie]
synonym: "down regulation of 5,10-CH(2)-H(4)folate reductase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of 5,10-CH2-H4folate reductase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [GOC:TermGenie]
synonym: "down regulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity" EXACT [GOC:TermGenie]
synonym: "down regulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity" EXACT [GOC:TermGenie]
synonym: "down regulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity" EXACT [GOC:TermGenie]
synonym: "down regulation of 5,10-methylenetetrahydropteroylglutamate reductase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of MetF" RELATED [GOC:TermGenie]
synonym: "down regulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [GOC:TermGenie]
synonym: "down regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity" EXACT [GOC:TermGenie]
synonym: "down regulation of methylenetetrahydrofolate reductase (NADPH(2)) activity" EXACT [GOC:TermGenie]
synonym: "down regulation of methylenetetrahydrofolate reductase (NADPH2)" EXACT [GOC:TermGenie]
synonym: "down regulation of methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [GOC:TermGenie]
synonym: "down regulation of N5,10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of N5,N10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of 1.7.99.5" RELATED [GOC:TermGenie]
synonym: "down-regulation of 5,10-CH(2)-H(4)folate reductase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of 5,10-CH2-H4folate reductase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of 5,10-methylenetetrahydropteroylglutamate reductase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of MetF" RELATED [GOC:TermGenie]
synonym: "down-regulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of methylenetetrahydrofolate reductase (NADPH(2)) activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of methylenetetrahydrofolate reductase (NADPH2)" EXACT [GOC:TermGenie]
synonym: "down-regulation of methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [GOC:TermGenie]
synonym: "down-regulation of N5,10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of N5,N10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of 1.7.99.5" RELATED [GOC:TermGenie]
synonym: "downregulation of 5,10-CH(2)-H(4)folate reductase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of 5,10-CH2-H4folate reductase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [GOC:TermGenie]
synonym: "downregulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity" EXACT [GOC:TermGenie]
synonym: "downregulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity" EXACT [GOC:TermGenie]
synonym: "downregulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity" EXACT [GOC:TermGenie]
synonym: "downregulation of 5,10-methylenetetrahydropteroylglutamate reductase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of MetF" RELATED [GOC:TermGenie]
synonym: "downregulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [GOC:TermGenie]
synonym: "downregulation of methylenetetrahydrofolate reductase (NAD(P)H) activity" EXACT [GOC:TermGenie]
synonym: "downregulation of methylenetetrahydrofolate reductase (NADPH(2)) activity" EXACT [GOC:TermGenie]
synonym: "downregulation of methylenetetrahydrofolate reductase (NADPH2)" EXACT [GOC:TermGenie]
synonym: "downregulation of methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [GOC:TermGenie]
synonym: "downregulation of N5,10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of N5,N10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of 1.7.99.5" RELATED [GOC:TermGenie]
synonym: "inhibition of 5,10-CH(2)-H(4)folate reductase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of 5,10-CH2-H4folate reductase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [GOC:TermGenie]
synonym: "inhibition of 5,10-methylenetetrahydrofolate reductase (FADH) activity" NARROW [GOC:TermGenie]
synonym: "inhibition of 5,10-methylenetetrahydrofolate reductase (FADH2) activity" NARROW [GOC:TermGenie]
synonym: "inhibition of 5,10-methylenetetrahydrofolate reductase (NADPH) activity" NARROW [GOC:TermGenie]
synonym: "inhibition of 5,10-methylenetetrahydropteroylglutamate reductase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of 5-methyltetrahydrofolate:NAD oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of MetF" RELATED [GOC:TermGenie]
synonym: "inhibition of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [GOC:TermGenie]
synonym: "inhibition of methylenetetrahydrofolate reductase (NAD(P)H) activity" NARROW [GOC:TermGenie]
synonym: "inhibition of methylenetetrahydrofolate reductase (NADPH(2)) activity" NARROW [GOC:TermGenie]
synonym: "inhibition of methylenetetrahydrofolate reductase (NADPH2)" NARROW [GOC:TermGenie]
synonym: "inhibition of methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [GOC:TermGenie]
synonym: "inhibition of N5,10-methylenetetrahydrofolate reductase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of N5,N10-methylenetetrahydrofolate reductase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of 1.7.99.5" RELATED [GOC:TermGenie]
synonym: "negative regulation of 5,10-CH(2)-H(4)folate reductase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of 5,10-CH2-H4folate reductase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of 5,10-methylenetetrahydropteroylglutamate reductase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of MetF" RELATED [GOC:TermGenie]
synonym: "negative regulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of methylenetetrahydrofolate reductase (NADPH(2)) activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of methylenetetrahydrofolate reductase (NADPH2)" EXACT [GOC:TermGenie]
synonym: "negative regulation of methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [GOC:TermGenie]
synonym: "negative regulation of N5,10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of N5,N10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie]
is_a: GO:0051354 ! negative regulation of oxidoreductase activity
is_a: GO:1903868 ! regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004489 ! methylenetetrahydrofolate reductase (NAD(P)H) activity
relationship: negatively_regulates GO:0004489 ! methylenetetrahydrofolate reductase (NAD(P)H) activity
created_by: rph
creation_date: 2015-02-05T13:26:25Z

[Term]
id: GO:1903870
name: positive regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of methylenetetrahydrofolate reductase (NAD(P)H) activity." [GO_REF:0000059, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:24769206]
synonym: "activation of 1.7.99.5" RELATED [GOC:TermGenie]
synonym: "activation of 5,10-CH(2)-H(4)folate reductase activity" NARROW [GOC:TermGenie]
synonym: "activation of 5,10-CH2-H4folate reductase activity" NARROW [GOC:TermGenie]
synonym: "activation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [GOC:TermGenie]
synonym: "activation of 5,10-methylenetetrahydrofolate reductase (FADH) activity" NARROW [GOC:TermGenie]
synonym: "activation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity" NARROW [GOC:TermGenie]
synonym: "activation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity" NARROW [GOC:TermGenie]
synonym: "activation of 5,10-methylenetetrahydropteroylglutamate reductase activity" NARROW [GOC:TermGenie]
synonym: "activation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "activation of 5-methyltetrahydrofolate:NAD oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "activation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "activation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "activation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "activation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "activation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "activation of MetF" RELATED [GOC:TermGenie]
synonym: "activation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" NARROW [GOC:TermGenie]
synonym: "activation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [GOC:TermGenie]
synonym: "activation of methylenetetrahydrofolate reductase (NAD(P)H) activity" NARROW [GOC:TermGenie]
synonym: "activation of methylenetetrahydrofolate reductase (NADPH(2)) activity" NARROW [GOC:TermGenie]
synonym: "activation of methylenetetrahydrofolate reductase (NADPH2)" NARROW [GOC:TermGenie]
synonym: "activation of methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [GOC:TermGenie]
synonym: "activation of N5,10-methylenetetrahydrofolate reductase activity" NARROW [GOC:TermGenie]
synonym: "activation of N5,N10-methylenetetrahydrofolate reductase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of 1.7.99.5" RELATED [GOC:TermGenie]
synonym: "positive regulation of 5,10-CH(2)-H(4)folate reductase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of 5,10-CH2-H4folate reductase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of 5,10-methylenetetrahydropteroylglutamate reductase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of MetF" RELATED [GOC:TermGenie]
synonym: "positive regulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of methylenetetrahydrofolate reductase (NADPH(2)) activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of methylenetetrahydrofolate reductase (NADPH2)" EXACT [GOC:TermGenie]
synonym: "positive regulation of methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [GOC:TermGenie]
synonym: "positive regulation of N5,10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of N5,N10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of 1.7.99.5" RELATED [GOC:TermGenie]
synonym: "up regulation of 5,10-CH(2)-H(4)folate reductase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of 5,10-CH2-H4folate reductase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [GOC:TermGenie]
synonym: "up regulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity" EXACT [GOC:TermGenie]
synonym: "up regulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity" EXACT [GOC:TermGenie]
synonym: "up regulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity" EXACT [GOC:TermGenie]
synonym: "up regulation of 5,10-methylenetetrahydropteroylglutamate reductase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of MetF" RELATED [GOC:TermGenie]
synonym: "up regulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity" EXACT [GOC:TermGenie]
synonym: "up regulation of methylenetetrahydrofolate reductase (NADPH(2)) activity" EXACT [GOC:TermGenie]
synonym: "up regulation of methylenetetrahydrofolate reductase (NADPH2)" EXACT [GOC:TermGenie]
synonym: "up regulation of methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [GOC:TermGenie]
synonym: "up regulation of N5,10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of N5,N10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of 1.7.99.5" RELATED [GOC:TermGenie]
synonym: "up-regulation of 5,10-CH(2)-H(4)folate reductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of 5,10-CH2-H4folate reductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of 5,10-methylenetetrahydropteroylglutamate reductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of MetF" RELATED [GOC:TermGenie]
synonym: "up-regulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of methylenetetrahydrofolate reductase (NADPH(2)) activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of methylenetetrahydrofolate reductase (NADPH2)" EXACT [GOC:TermGenie]
synonym: "up-regulation of methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [GOC:TermGenie]
synonym: "up-regulation of N5,10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of N5,N10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of 1.7.99.5" RELATED [GOC:TermGenie]
synonym: "upregulation of 5,10-CH(2)-H(4)folate reductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of 5,10-CH2-H4folate reductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [GOC:TermGenie]
synonym: "upregulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity" EXACT [GOC:TermGenie]
synonym: "upregulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity" EXACT [GOC:TermGenie]
synonym: "upregulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity" EXACT [GOC:TermGenie]
synonym: "upregulation of 5,10-methylenetetrahydropteroylglutamate reductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of MetF" RELATED [GOC:TermGenie]
synonym: "upregulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [GOC:TermGenie]
synonym: "upregulation of methylenetetrahydrofolate reductase (NAD(P)H) activity" EXACT [GOC:TermGenie]
synonym: "upregulation of methylenetetrahydrofolate reductase (NADPH(2)) activity" EXACT [GOC:TermGenie]
synonym: "upregulation of methylenetetrahydrofolate reductase (NADPH2)" EXACT [GOC:TermGenie]
synonym: "upregulation of methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [GOC:TermGenie]
synonym: "upregulation of N5,10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of N5,N10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie]
is_a: GO:0051353 ! positive regulation of oxidoreductase activity
is_a: GO:1903868 ! regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004489 ! methylenetetrahydrofolate reductase (NAD(P)H) activity
relationship: positively_regulates GO:0004489 ! methylenetetrahydrofolate reductase (NAD(P)H) activity
created_by: rph
creation_date: 2015-02-05T13:26:33Z

[Term]
id: GO:1903871
name: DNA recombinase mediator complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a DNA recombinase mediator complex." [GO_REF:0000079, GOC:rb, GOC:TermGenie, PMID:18347097]
synonym: "DNA recombinase mediator complex formation" EXACT [GOC:TermGenie]
is_a: GO:0006461 ! protein complex assembly
created_by: rb
creation_date: 2015-02-05T23:05:10Z

[Term]
id: GO:1903872
name: regulation of DNA recombinase mediator complex assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA recombinase mediator complex assembly." [GO_REF:0000058, GOC:rb, GOC:TermGenie, PMID:18347097]
synonym: "regulation of DNA recombinase mediator complex formation" EXACT [GOC:TermGenie]
is_a: GO:0043254 ! regulation of protein complex assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1903871 ! DNA recombinase mediator complex assembly
relationship: regulates GO:1903871 ! DNA recombinase mediator complex assembly
created_by: rb
creation_date: 2015-02-05T23:36:45Z

[Term]
id: GO:1903873
name: negative regulation of DNA recombinase mediator complex assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA recombinase mediator complex assembly." [GO_REF:0000058, GOC:rb, GOC:TermGenie, PMID:18347097]
synonym: "down regulation of DNA recombinase mediator complex assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of DNA recombinase mediator complex formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA recombinase mediator complex assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA recombinase mediator complex formation" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA recombinase mediator complex assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA recombinase mediator complex formation" EXACT [GOC:TermGenie]
synonym: "inhibition of DNA recombinase mediator complex assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA recombinase mediator complex formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of DNA recombinase mediator complex formation" EXACT [GOC:TermGenie]
is_a: GO:0031333 ! negative regulation of protein complex assembly
is_a: GO:1903872 ! regulation of DNA recombinase mediator complex assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1903871 ! DNA recombinase mediator complex assembly
relationship: negatively_regulates GO:1903871 ! DNA recombinase mediator complex assembly
created_by: rb
creation_date: 2015-02-05T23:36:54Z

[Term]
id: GO:1903874
name: ferrous iron transmembrane transport
namespace: biological_process
def: "The directed movement of ferrous iron (iron(2+)) across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:11390404]
synonym: "iron(2+) transmembrane transport" EXACT []
is_a: GO:0015684 ! ferrous iron transport
is_a: GO:0034755 ! iron ion transmembrane transport
created_by: vw
creation_date: 2015-02-06T11:29:22Z

[Term]
id: GO:1903875
name: corticosterone binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with corticosterone." [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:10802282]
is_a: GO:0043178 ! alcohol binding
is_a: GO:1990239 ! steroid hormone binding
created_by: mr
creation_date: 2015-02-06T16:02:35Z

[Term]
id: GO:1903876
name: 11-deoxycortisol binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with 11-deoxycortisol." [GO_REF:0000067, GOC:TermGenie, PMID:10802282]
is_a: GO:1990239 ! steroid hormone binding
created_by: mr
creation_date: 2015-02-06T16:02:44Z

[Term]
id: GO:1903877
name: 21-deoxycortisol binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with 21-deoxycortisol." [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:10802282]
is_a: GO:0005496 ! steroid binding
created_by: mr
creation_date: 2015-02-06T16:02:54Z

[Term]
id: GO:1903878
name: 11-deoxycorticosterone binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with 11-deoxycorticosterone." [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:10802282]
is_a: GO:0043178 ! alcohol binding
is_a: GO:1990239 ! steroid hormone binding
created_by: mr
creation_date: 2015-02-06T16:03:03Z

[Term]
id: GO:1903879
name: 11beta-hydroxyprogesterone binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with 11beta-hydroxyprogesterone." [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:10802282]
is_a: GO:0005496 ! steroid binding
is_a: GO:0043178 ! alcohol binding
created_by: mr
creation_date: 2015-02-06T16:03:12Z

[Term]
id: GO:1903880
name: 17alpha-hydroxyprogesterone binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with 17alpha-hydroxyprogesterone." [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:10802282]
is_a: GO:0005496 ! steroid binding
is_a: GO:0043178 ! alcohol binding
created_by: mr
creation_date: 2015-02-06T16:03:22Z

[Term]
id: GO:1903881
name: regulation of interleukin-17-mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of interleukin-17-mediated signaling pathway." [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:20054338]
synonym: "regulation of IL-17-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "regulation of IL-17-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "regulation of interleukin-17-mediated signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097400 ! interleukin-17-mediated signaling pathway
relationship: regulates GO:0097400 ! interleukin-17-mediated signaling pathway
created_by: krc
creation_date: 2015-02-06T16:26:38Z

[Term]
id: GO:1903882
name: negative regulation of interleukin-17-mediated signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-17-mediated signaling pathway." [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:20054338]
synonym: "down regulation of IL-17-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of IL-17-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of interleukin-17-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of interleukin-17-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of IL-17-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of IL-17-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of interleukin-17-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of interleukin-17-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of IL-17-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of IL-17-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of interleukin-17-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of interleukin-17-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of IL-17-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of IL-17-mediated signalling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of interleukin-17-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of interleukin-17-mediated signalling pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of IL-17-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of IL-17-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of interleukin-17-mediated signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway
is_a: GO:1903881 ! regulation of interleukin-17-mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097400 ! interleukin-17-mediated signaling pathway
relationship: negatively_regulates GO:0097400 ! interleukin-17-mediated signaling pathway
created_by: krc
creation_date: 2015-02-06T16:26:47Z

[Term]
id: GO:1903883
name: positive regulation of interleukin-17-mediated signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of interleukin-17-mediated signaling pathway." [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:20054338]
synonym: "activation of IL-17-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of IL-17-mediated signalling pathway" NARROW [GOC:TermGenie]
synonym: "activation of interleukin-17-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of interleukin-17-mediated signalling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of IL-17-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of IL-17-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of interleukin-17-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of IL-17-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of IL-17-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of interleukin-17-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of interleukin-17-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of IL-17-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of IL-17-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of interleukin-17-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of interleukin-17-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of IL-17-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of IL-17-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of interleukin-17-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of interleukin-17-mediated signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway
is_a: GO:1903881 ! regulation of interleukin-17-mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097400 ! interleukin-17-mediated signaling pathway
relationship: positively_regulates GO:0097400 ! interleukin-17-mediated signaling pathway
created_by: krc
creation_date: 2015-02-06T16:26:56Z

[Term]
id: GO:1903884
name: regulation of chemokine (C-C motif) ligand 20 production
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chemokine (C-C motif) ligand 20 production." [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:20054338]
synonym: "regulation of C-C motif chemokine 20 production" EXACT [GOC:TermGenie]
synonym: "regulation of CCL-20 production" EXACT [GOC:TermGenie]
synonym: "regulation of CCL20 production" EXACT [GOC:TermGenie]
is_a: GO:0032642 ! regulation of chemokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0036392 ! chemokine (C-C motif) ligand 20 production
relationship: regulates GO:0036392 ! chemokine (C-C motif) ligand 20 production
created_by: krc
creation_date: 2015-02-06T16:31:02Z

[Term]
id: GO:1903885
name: negative regulation of chemokine (C-C motif) ligand 20 production
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chemokine (C-C motif) ligand 20 production." [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:20054338]
synonym: "down regulation of C-C motif chemokine 20 production" EXACT [GOC:TermGenie]
synonym: "down regulation of CCL-20 production" EXACT [GOC:TermGenie]
synonym: "down regulation of CCL20 production" EXACT [GOC:TermGenie]
synonym: "down regulation of chemokine (C-C motif) ligand 20 production" EXACT [GOC:TermGenie]
synonym: "down-regulation of C-C motif chemokine 20 production" EXACT [GOC:TermGenie]
synonym: "down-regulation of CCL-20 production" EXACT [GOC:TermGenie]
synonym: "down-regulation of CCL20 production" EXACT [GOC:TermGenie]
synonym: "down-regulation of chemokine (C-C motif) ligand 20 production" EXACT [GOC:TermGenie]
synonym: "downregulation of C-C motif chemokine 20 production" EXACT [GOC:TermGenie]
synonym: "downregulation of CCL-20 production" EXACT [GOC:TermGenie]
synonym: "downregulation of CCL20 production" EXACT [GOC:TermGenie]
synonym: "downregulation of chemokine (C-C motif) ligand 20 production" EXACT [GOC:TermGenie]
synonym: "inhibition of C-C motif chemokine 20 production" NARROW [GOC:TermGenie]
synonym: "inhibition of CCL-20 production" NARROW [GOC:TermGenie]
synonym: "inhibition of CCL20 production" NARROW [GOC:TermGenie]
synonym: "inhibition of chemokine (C-C motif) ligand 20 production" NARROW [GOC:TermGenie]
synonym: "negative regulation of C-C motif chemokine 20 production" EXACT [GOC:TermGenie]
synonym: "negative regulation of CCL-20 production" EXACT [GOC:TermGenie]
synonym: "negative regulation of CCL20 production" EXACT [GOC:TermGenie]
is_a: GO:0032682 ! negative regulation of chemokine production
is_a: GO:1903884 ! regulation of chemokine (C-C motif) ligand 20 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0036392 ! chemokine (C-C motif) ligand 20 production
relationship: negatively_regulates GO:0036392 ! chemokine (C-C motif) ligand 20 production
created_by: krc
creation_date: 2015-02-06T16:31:11Z

[Term]
id: GO:1903886
name: positive regulation of chemokine (C-C motif) ligand 20 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chemokine (C-C motif) ligand 20 production." [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:20054338]
synonym: "activation of C-C motif chemokine 20 production" NARROW [GOC:TermGenie]
synonym: "activation of CCL-20 production" NARROW [GOC:TermGenie]
synonym: "activation of CCL20 production" NARROW [GOC:TermGenie]
synonym: "activation of chemokine (C-C motif) ligand 20 production" NARROW [GOC:TermGenie]
synonym: "positive regulation of C-C motif chemokine 20 production" EXACT [GOC:TermGenie]
synonym: "positive regulation of CCL-20 production" EXACT [GOC:TermGenie]
synonym: "positive regulation of CCL20 production" EXACT [GOC:TermGenie]
synonym: "up regulation of C-C motif chemokine 20 production" EXACT [GOC:TermGenie]
synonym: "up regulation of CCL-20 production" EXACT [GOC:TermGenie]
synonym: "up regulation of CCL20 production" EXACT [GOC:TermGenie]
synonym: "up regulation of chemokine (C-C motif) ligand 20 production" EXACT [GOC:TermGenie]
synonym: "up-regulation of C-C motif chemokine 20 production" EXACT [GOC:TermGenie]
synonym: "up-regulation of CCL-20 production" EXACT [GOC:TermGenie]
synonym: "up-regulation of CCL20 production" EXACT [GOC:TermGenie]
synonym: "up-regulation of chemokine (C-C motif) ligand 20 production" EXACT [GOC:TermGenie]
synonym: "upregulation of C-C motif chemokine 20 production" EXACT [GOC:TermGenie]
synonym: "upregulation of CCL-20 production" EXACT [GOC:TermGenie]
synonym: "upregulation of CCL20 production" EXACT [GOC:TermGenie]
synonym: "upregulation of chemokine (C-C motif) ligand 20 production" EXACT [GOC:TermGenie]
is_a: GO:0032722 ! positive regulation of chemokine production
is_a: GO:1903884 ! regulation of chemokine (C-C motif) ligand 20 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0036392 ! chemokine (C-C motif) ligand 20 production
relationship: positively_regulates GO:0036392 ! chemokine (C-C motif) ligand 20 production
created_by: krc
creation_date: 2015-02-06T16:31:20Z

[Term]
id: GO:1903887
name: motile primary cilium assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a motile primary cilium." [GO_REF:0000079, GOC:krc, GOC:TermGenie, PMID:19776033]
synonym: "motile primary cilia assembly" EXACT [GOC:TermGenie]
synonym: "motile primary cilia formation" EXACT [GOC:TermGenie]
synonym: "motile primary cilium formation" EXACT [GOC:TermGenie]
synonym: "nodal cilium assembly" RELATED [GOC:TermGenie]
synonym: "nodal cilium formation" RELATED [GOC:TermGenie]
is_a: GO:0042384 ! cilium assembly
created_by: krc
creation_date: 2015-02-06T17:23:23Z

[Term]
id: GO:1903888
name: regulation of plant epidermal cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of plant epidermal cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:123345]
is_a: GO:0045595 ! regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0090627 ! plant epidermal cell differentiation
relationship: regulates GO:0090627 ! plant epidermal cell differentiation
created_by: tb
creation_date: 2015-02-06T22:29:38Z

[Term]
id: GO:1903889
name: negative regulation of plant epidermal cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of plant epidermal cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:123345]
synonym: "down regulation of plant epidermal cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of plant epidermal cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of plant epidermal cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of plant epidermal cell differentiation" NARROW [GOC:TermGenie]
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:1903888 ! regulation of plant epidermal cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0090627 ! plant epidermal cell differentiation
relationship: negatively_regulates GO:0090627 ! plant epidermal cell differentiation
created_by: tb
creation_date: 2015-02-06T22:29:52Z

[Term]
id: GO:1903890
name: positive regulation of plant epidermal cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of plant epidermal cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:123345]
synonym: "activation of plant epidermal cell differentiation" NARROW [GOC:TermGenie]
synonym: "up regulation of plant epidermal cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of plant epidermal cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of plant epidermal cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:1903888 ! regulation of plant epidermal cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0090627 ! plant epidermal cell differentiation
relationship: positively_regulates GO:0090627 ! plant epidermal cell differentiation
created_by: tb
creation_date: 2015-02-06T22:30:02Z

[Term]
id: GO:1903891
name: regulation of ATF6-mediated unfolded protein response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the ATF6-mediated unfolded protein response." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22013210]
synonym: "regulation of activating transcription factor 6 signaling in unfolded protein response" EXACT [GOC:TermGenie]
synonym: "regulation of ATF6 branch of UPR" EXACT [GOC:TermGenie]
synonym: "regulation of ATF6 signal transduction pathway" BROAD [GOC:TermGenie]
synonym: "regulation of ATF6 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "regulation of ATF6-alpha UPR branch" NARROW [GOC:TermGenie]
synonym: "regulation of ATF6-beta UPR branch" NARROW [GOC:TermGenie]
synonym: "regulation of endoplasmic reticulum unfolded protein response; ATF6 signaling" EXACT [GOC:TermGenie]
synonym: "regulation of UPR signaling by ATF6 stress sensor" EXACT [GOC:TermGenie]
is_a: GO:1900101 ! regulation of endoplasmic reticulum unfolded protein response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0036500 ! ATF6-mediated unfolded protein response
relationship: regulates GO:0036500 ! ATF6-mediated unfolded protein response
created_by: bf
creation_date: 2015-02-09T10:17:15Z

[Term]
id: GO:1903892
name: negative regulation of ATF6-mediated unfolded protein response
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the ATF6-mediated unfolded protein response." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22013210]
synonym: "down regulation of activating transcription factor 6 signaling in unfolded protein response" EXACT [GOC:TermGenie]
synonym: "down regulation of ATF6 branch of UPR" EXACT [GOC:TermGenie]
synonym: "down regulation of ATF6 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "down regulation of ATF6-alpha UPR branch" NARROW [GOC:TermGenie]
synonym: "down regulation of ATF6-beta UPR branch" NARROW [GOC:TermGenie]
synonym: "down regulation of ATF6-mediated unfolded protein response" EXACT [GOC:TermGenie]
synonym: "down regulation of endoplasmic reticulum unfolded protein response; ATF6 signaling" EXACT [GOC:TermGenie]
synonym: "down regulation of UPR signaling by ATF6 stress sensor" EXACT [GOC:TermGenie]
synonym: "down-regulation of activating transcription factor 6 signaling in unfolded protein response" EXACT [GOC:TermGenie]
synonym: "down-regulation of ATF6 branch of UPR" EXACT [GOC:TermGenie]
synonym: "down-regulation of ATF6 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "down-regulation of ATF6-alpha UPR branch" NARROW [GOC:TermGenie]
synonym: "down-regulation of ATF6-beta UPR branch" NARROW [GOC:TermGenie]
synonym: "down-regulation of ATF6-mediated unfolded protein response" EXACT [GOC:TermGenie]
synonym: "down-regulation of endoplasmic reticulum unfolded protein response; ATF6 signaling" EXACT [GOC:TermGenie]
synonym: "down-regulation of UPR signaling by ATF6 stress sensor" EXACT [GOC:TermGenie]
synonym: "downregulation of activating transcription factor 6 signaling in unfolded protein response" EXACT [GOC:TermGenie]
synonym: "downregulation of ATF6 branch of UPR" EXACT [GOC:TermGenie]
synonym: "downregulation of ATF6 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "downregulation of ATF6-alpha UPR branch" NARROW [GOC:TermGenie]
synonym: "downregulation of ATF6-beta UPR branch" NARROW [GOC:TermGenie]
synonym: "downregulation of ATF6-mediated unfolded protein response" EXACT [GOC:TermGenie]
synonym: "downregulation of endoplasmic reticulum unfolded protein response; ATF6 signaling" EXACT [GOC:TermGenie]
synonym: "downregulation of UPR signaling by ATF6 stress sensor" EXACT [GOC:TermGenie]
synonym: "inhibition of activating transcription factor 6 signaling in unfolded protein response" NARROW [GOC:TermGenie]
synonym: "inhibition of ATF6 branch of UPR" NARROW [GOC:TermGenie]
synonym: "inhibition of ATF6 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "inhibition of ATF6-alpha UPR branch" NARROW [GOC:TermGenie]
synonym: "inhibition of ATF6-beta UPR branch" NARROW [GOC:TermGenie]
synonym: "inhibition of ATF6-mediated unfolded protein response" NARROW [GOC:TermGenie]
synonym: "inhibition of endoplasmic reticulum unfolded protein response; ATF6 signaling" NARROW [GOC:TermGenie]
synonym: "inhibition of UPR signaling by ATF6 stress sensor" NARROW [GOC:TermGenie]
synonym: "negative regulation of activating transcription factor 6 signaling in unfolded protein response" EXACT [GOC:TermGenie]
synonym: "negative regulation of ATF6 branch of UPR" EXACT [GOC:TermGenie]
synonym: "negative regulation of ATF6 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "negative regulation of ATF6-alpha UPR branch" NARROW [GOC:TermGenie]
synonym: "negative regulation of ATF6-beta UPR branch" NARROW [GOC:TermGenie]
synonym: "negative regulation of endoplasmic reticulum unfolded protein response; ATF6 signaling" EXACT [GOC:TermGenie]
synonym: "negative regulation of UPR signaling by ATF6 stress sensor" EXACT [GOC:TermGenie]
is_a: GO:1900102 ! negative regulation of endoplasmic reticulum unfolded protein response
is_a: GO:1903891 ! regulation of ATF6-mediated unfolded protein response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0036500 ! ATF6-mediated unfolded protein response
relationship: negatively_regulates GO:0036500 ! ATF6-mediated unfolded protein response
created_by: bf
creation_date: 2015-02-09T10:17:26Z

[Term]
id: GO:1903893
name: positive regulation of ATF6-mediated unfolded protein response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the ATF6-mediated unfolded protein response." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22013210]
synonym: "activation of activating transcription factor 6 signaling in unfolded protein response" NARROW [GOC:TermGenie]
synonym: "activation of ATF6 branch of UPR" NARROW [GOC:TermGenie]
synonym: "activation of ATF6 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "activation of ATF6-alpha UPR branch" NARROW [GOC:TermGenie]
synonym: "activation of ATF6-beta UPR branch" NARROW [GOC:TermGenie]
synonym: "activation of ATF6-mediated unfolded protein response" NARROW [GOC:TermGenie]
synonym: "activation of endoplasmic reticulum unfolded protein response; ATF6 signaling" NARROW [GOC:TermGenie]
synonym: "activation of UPR signaling by ATF6 stress sensor" NARROW [GOC:TermGenie]
synonym: "positive regulation of activating transcription factor 6 signaling in unfolded protein response" EXACT [GOC:TermGenie]
synonym: "positive regulation of ATF6 branch of UPR" EXACT [GOC:TermGenie]
synonym: "positive regulation of ATF6 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "positive regulation of ATF6-alpha UPR branch" NARROW [GOC:TermGenie]
synonym: "positive regulation of ATF6-beta UPR branch" NARROW [GOC:TermGenie]
synonym: "positive regulation of endoplasmic reticulum unfolded protein response; ATF6 signaling" EXACT [GOC:TermGenie]
synonym: "positive regulation of UPR signaling by ATF6 stress sensor" EXACT [GOC:TermGenie]
synonym: "up regulation of activating transcription factor 6 signaling in unfolded protein response" EXACT [GOC:TermGenie]
synonym: "up regulation of ATF6 branch of UPR" EXACT [GOC:TermGenie]
synonym: "up regulation of ATF6 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "up regulation of ATF6-alpha UPR branch" NARROW [GOC:TermGenie]
synonym: "up regulation of ATF6-beta UPR branch" NARROW [GOC:TermGenie]
synonym: "up regulation of ATF6-mediated unfolded protein response" EXACT [GOC:TermGenie]
synonym: "up regulation of endoplasmic reticulum unfolded protein response; ATF6 signaling" EXACT [GOC:TermGenie]
synonym: "up regulation of UPR signaling by ATF6 stress sensor" EXACT [GOC:TermGenie]
synonym: "up-regulation of activating transcription factor 6 signaling in unfolded protein response" EXACT [GOC:TermGenie]
synonym: "up-regulation of ATF6 branch of UPR" EXACT [GOC:TermGenie]
synonym: "up-regulation of ATF6 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "up-regulation of ATF6-alpha UPR branch" NARROW [GOC:TermGenie]
synonym: "up-regulation of ATF6-beta UPR branch" NARROW [GOC:TermGenie]
synonym: "up-regulation of ATF6-mediated unfolded protein response" EXACT [GOC:TermGenie]
synonym: "up-regulation of endoplasmic reticulum unfolded protein response; ATF6 signaling" EXACT [GOC:TermGenie]
synonym: "up-regulation of UPR signaling by ATF6 stress sensor" EXACT [GOC:TermGenie]
synonym: "upregulation of activating transcription factor 6 signaling in unfolded protein response" EXACT [GOC:TermGenie]
synonym: "upregulation of ATF6 branch of UPR" EXACT [GOC:TermGenie]
synonym: "upregulation of ATF6 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "upregulation of ATF6-alpha UPR branch" NARROW [GOC:TermGenie]
synonym: "upregulation of ATF6-beta UPR branch" NARROW [GOC:TermGenie]
synonym: "upregulation of ATF6-mediated unfolded protein response" EXACT [GOC:TermGenie]
synonym: "upregulation of endoplasmic reticulum unfolded protein response; ATF6 signaling" EXACT [GOC:TermGenie]
synonym: "upregulation of UPR signaling by ATF6 stress sensor" EXACT [GOC:TermGenie]
is_a: GO:1900103 ! positive regulation of endoplasmic reticulum unfolded protein response
is_a: GO:1903891 ! regulation of ATF6-mediated unfolded protein response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0036500 ! ATF6-mediated unfolded protein response
relationship: positively_regulates GO:0036500 ! ATF6-mediated unfolded protein response
created_by: bf
creation_date: 2015-02-09T10:17:36Z

[Term]
id: GO:1903894
name: regulation of IRE1-mediated unfolded protein response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the IRE1-mediated unfolded protein response." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22013210]
synonym: "regulation of endoplasmic reticulum unfolded protein response; IRE1 signaling" EXACT [GOC:TermGenie]
synonym: "regulation of ERN1-mediated unfolded protein response" RELATED [HGNC:3449]
synonym: "regulation of inositol-requiring transmembrane kinase/endonuclease signal transduction" RELATED [GOC:TermGenie]
synonym: "regulation of IRE1 branch of UPR" EXACT [GOC:TermGenie]
synonym: "regulation of IRE1 signal transduction pathway" BROAD [GOC:TermGenie]
synonym: "regulation of IRE1 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "regulation of IRE1alpha unfolded protein response" NARROW [GOC:TermGenie]
synonym: "regulation of IRE1p unfolded protein response" NARROW [GOC:TermGenie]
synonym: "regulation of UPR signaling by IRE1 stress sensor" EXACT [GOC:TermGenie]
is_a: GO:1900101 ! regulation of endoplasmic reticulum unfolded protein response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0036498 ! IRE1-mediated unfolded protein response
relationship: regulates GO:0036498 ! IRE1-mediated unfolded protein response
created_by: bf
creation_date: 2015-02-09T10:17:46Z

[Term]
id: GO:1903895
name: negative regulation of IRE1-mediated unfolded protein response
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the IRE1-mediated unfolded protein response." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22013210]
synonym: "down regulation of endoplasmic reticulum unfolded protein response; IRE1 signaling" EXACT [GOC:TermGenie]
synonym: "down regulation of inositol-requiring transmembrane kinase/endonuclease signal transduction" RELATED [GOC:TermGenie]
synonym: "down regulation of IRE1 branch of UPR" EXACT [GOC:TermGenie]
synonym: "down regulation of IRE1 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "down regulation of IRE1-mediated unfolded protein response" EXACT [GOC:TermGenie]
synonym: "down regulation of IRE1alpha unfolded protein response" NARROW [GOC:TermGenie]
synonym: "down regulation of IRE1p unfolded protein response" NARROW [GOC:TermGenie]
synonym: "down regulation of UPR signaling by IRE1 stress sensor" EXACT [GOC:TermGenie]
synonym: "down-regulation of endoplasmic reticulum unfolded protein response; IRE1 signaling" EXACT [GOC:TermGenie]
synonym: "down-regulation of inositol-requiring transmembrane kinase/endonuclease signal transduction" RELATED [GOC:TermGenie]
synonym: "down-regulation of IRE1 branch of UPR" EXACT [GOC:TermGenie]
synonym: "down-regulation of IRE1 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "down-regulation of IRE1-mediated unfolded protein response" EXACT [GOC:TermGenie]
synonym: "down-regulation of IRE1alpha unfolded protein response" NARROW [GOC:TermGenie]
synonym: "down-regulation of IRE1p unfolded protein response" NARROW [GOC:TermGenie]
synonym: "down-regulation of UPR signaling by IRE1 stress sensor" EXACT [GOC:TermGenie]
synonym: "downregulation of endoplasmic reticulum unfolded protein response; IRE1 signaling" EXACT [GOC:TermGenie]
synonym: "downregulation of inositol-requiring transmembrane kinase/endonuclease signal transduction" RELATED [GOC:TermGenie]
synonym: "downregulation of IRE1 branch of UPR" EXACT [GOC:TermGenie]
synonym: "downregulation of IRE1 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "downregulation of IRE1-mediated unfolded protein response" EXACT [GOC:TermGenie]
synonym: "downregulation of IRE1alpha unfolded protein response" NARROW [GOC:TermGenie]
synonym: "downregulation of IRE1p unfolded protein response" NARROW [GOC:TermGenie]
synonym: "downregulation of UPR signaling by IRE1 stress sensor" EXACT [GOC:TermGenie]
synonym: "inhibition of endoplasmic reticulum unfolded protein response; IRE1 signaling" NARROW [GOC:TermGenie]
synonym: "inhibition of inositol-requiring transmembrane kinase/endonuclease signal transduction" RELATED [GOC:TermGenie]
synonym: "inhibition of IRE1 branch of UPR" NARROW [GOC:TermGenie]
synonym: "inhibition of IRE1 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "inhibition of IRE1-mediated unfolded protein response" NARROW [GOC:TermGenie]
synonym: "inhibition of IRE1alpha unfolded protein response" NARROW [GOC:TermGenie]
synonym: "inhibition of IRE1p unfolded protein response" NARROW [GOC:TermGenie]
synonym: "inhibition of UPR signaling by IRE1 stress sensor" NARROW [GOC:TermGenie]
synonym: "negative regulation of endoplasmic reticulum unfolded protein response; IRE1 signaling" EXACT [GOC:TermGenie]
synonym: "negative regulation of ERN1-mediated unfolded protein response" RELATED [HGNC:3449]
synonym: "negative regulation of inositol-requiring transmembrane kinase/endonuclease signal transduction" RELATED [GOC:TermGenie]
synonym: "negative regulation of IRE1 branch of UPR" EXACT [GOC:TermGenie]
synonym: "negative regulation of IRE1 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "negative regulation of IRE1alpha unfolded protein response" NARROW [GOC:TermGenie]
synonym: "negative regulation of IRE1p unfolded protein response" NARROW [GOC:TermGenie]
synonym: "negative regulation of UPR signaling by IRE1 stress sensor" EXACT [GOC:TermGenie]
is_a: GO:1900102 ! negative regulation of endoplasmic reticulum unfolded protein response
is_a: GO:1903894 ! regulation of IRE1-mediated unfolded protein response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0036498 ! IRE1-mediated unfolded protein response
relationship: negatively_regulates GO:0036498 ! IRE1-mediated unfolded protein response
created_by: bf
creation_date: 2015-02-09T10:17:55Z

[Term]
id: GO:1903896
name: positive regulation of IRE1-mediated unfolded protein response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the IRE1-mediated unfolded protein response." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22013210]
synonym: "activation of endoplasmic reticulum unfolded protein response; IRE1 signaling" NARROW [GOC:TermGenie]
synonym: "activation of inositol-requiring transmembrane kinase/endonuclease signal transduction" RELATED [GOC:TermGenie]
synonym: "activation of IRE1 branch of UPR" NARROW [GOC:TermGenie]
synonym: "activation of IRE1 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "activation of IRE1-mediated unfolded protein response" NARROW [GOC:TermGenie]
synonym: "activation of IRE1alpha unfolded protein response" NARROW [GOC:TermGenie]
synonym: "activation of IRE1p unfolded protein response" NARROW [GOC:TermGenie]
synonym: "activation of UPR signaling by IRE1 stress sensor" NARROW [GOC:TermGenie]
synonym: "positive regulation of endoplasmic reticulum unfolded protein response; IRE1 signaling" EXACT [GOC:TermGenie]
synonym: "positive regulation of ERN1-mediated unfolded protein response" RELATED [HGNC:3449]
synonym: "positive regulation of inositol-requiring transmembrane kinase/endonuclease signal transduction" RELATED [GOC:TermGenie]
synonym: "positive regulation of IRE1 branch of UPR" EXACT [GOC:TermGenie]
synonym: "positive regulation of IRE1 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "positive regulation of IRE1alpha unfolded protein response" NARROW [GOC:TermGenie]
synonym: "positive regulation of IRE1p unfolded protein response" NARROW [GOC:TermGenie]
synonym: "positive regulation of UPR signaling by IRE1 stress sensor" EXACT [GOC:TermGenie]
synonym: "up regulation of endoplasmic reticulum unfolded protein response; IRE1 signaling" EXACT [GOC:TermGenie]
synonym: "up regulation of inositol-requiring transmembrane kinase/endonuclease signal transduction" RELATED [GOC:TermGenie]
synonym: "up regulation of IRE1 branch of UPR" EXACT [GOC:TermGenie]
synonym: "up regulation of IRE1 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "up regulation of IRE1-mediated unfolded protein response" EXACT [GOC:TermGenie]
synonym: "up regulation of IRE1alpha unfolded protein response" NARROW [GOC:TermGenie]
synonym: "up regulation of IRE1p unfolded protein response" NARROW [GOC:TermGenie]
synonym: "up regulation of UPR signaling by IRE1 stress sensor" EXACT [GOC:TermGenie]
synonym: "up-regulation of endoplasmic reticulum unfolded protein response; IRE1 signaling" EXACT [GOC:TermGenie]
synonym: "up-regulation of inositol-requiring transmembrane kinase/endonuclease signal transduction" RELATED [GOC:TermGenie]
synonym: "up-regulation of IRE1 branch of UPR" EXACT [GOC:TermGenie]
synonym: "up-regulation of IRE1 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "up-regulation of IRE1-mediated unfolded protein response" EXACT [GOC:TermGenie]
synonym: "up-regulation of IRE1alpha unfolded protein response" NARROW [GOC:TermGenie]
synonym: "up-regulation of IRE1p unfolded protein response" NARROW [GOC:TermGenie]
synonym: "up-regulation of UPR signaling by IRE1 stress sensor" EXACT [GOC:TermGenie]
synonym: "upregulation of endoplasmic reticulum unfolded protein response; IRE1 signaling" EXACT [GOC:TermGenie]
synonym: "upregulation of inositol-requiring transmembrane kinase/endonuclease signal transduction" RELATED [GOC:TermGenie]
synonym: "upregulation of IRE1 branch of UPR" EXACT [GOC:TermGenie]
synonym: "upregulation of IRE1 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "upregulation of IRE1-mediated unfolded protein response" EXACT [GOC:TermGenie]
synonym: "upregulation of IRE1alpha unfolded protein response" NARROW [GOC:TermGenie]
synonym: "upregulation of IRE1p unfolded protein response" NARROW [GOC:TermGenie]
synonym: "upregulation of UPR signaling by IRE1 stress sensor" EXACT [GOC:TermGenie]
is_a: GO:1900103 ! positive regulation of endoplasmic reticulum unfolded protein response
is_a: GO:1903894 ! regulation of IRE1-mediated unfolded protein response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0036498 ! IRE1-mediated unfolded protein response
relationship: positively_regulates GO:0036498 ! IRE1-mediated unfolded protein response
created_by: bf
creation_date: 2015-02-09T10:18:04Z

[Term]
id: GO:1903897
name: regulation of PERK-mediated unfolded protein response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the PERK-mediated unfolded protein response." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22013210]
synonym: "regulation of EIF2AK3-mediated unfolded protein response" RELATED [HGNC:3255]
synonym: "regulation of endoplasmic reticulum unfolded protein response; PERK signaling" EXACT [GOC:TermGenie]
synonym: "regulation of PERK branch of UPR" EXACT [GOC:TermGenie]
synonym: "regulation of PERK signal transduction pathway" BROAD [GOC:TermGenie]
synonym: "regulation of PERK signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "regulation of PKR-like ER kinase signal transduction" EXACT [GOC:TermGenie]
synonym: "regulation of UPR signaling by PERK stress sensor" EXACT [GOC:TermGenie]
is_a: GO:1900101 ! regulation of endoplasmic reticulum unfolded protein response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0036499 ! PERK-mediated unfolded protein response
relationship: regulates GO:0036499 ! PERK-mediated unfolded protein response
created_by: bf
creation_date: 2015-02-09T10:18:14Z

[Term]
id: GO:1903898
name: negative regulation of PERK-mediated unfolded protein response
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the PERK-mediated unfolded protein response." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22013210]
synonym: "down regulation of endoplasmic reticulum unfolded protein response; PERK signaling" EXACT [GOC:TermGenie]
synonym: "down regulation of PERK branch of UPR" EXACT [GOC:TermGenie]
synonym: "down regulation of PERK signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "down regulation of PERK-mediated unfolded protein response" EXACT [GOC:TermGenie]
synonym: "down regulation of PKR-like ER kinase signal transduction" EXACT [GOC:TermGenie]
synonym: "down regulation of UPR signaling by PERK stress sensor" EXACT [GOC:TermGenie]
synonym: "down-regulation of endoplasmic reticulum unfolded protein response; PERK signaling" EXACT [GOC:TermGenie]
synonym: "down-regulation of PERK branch of UPR" EXACT [GOC:TermGenie]
synonym: "down-regulation of PERK signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "down-regulation of PERK-mediated unfolded protein response" EXACT [GOC:TermGenie]
synonym: "down-regulation of PKR-like ER kinase signal transduction" EXACT [GOC:TermGenie]
synonym: "down-regulation of UPR signaling by PERK stress sensor" EXACT [GOC:TermGenie]
synonym: "downregulation of endoplasmic reticulum unfolded protein response; PERK signaling" EXACT [GOC:TermGenie]
synonym: "downregulation of PERK branch of UPR" EXACT [GOC:TermGenie]
synonym: "downregulation of PERK signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "downregulation of PERK-mediated unfolded protein response" EXACT [GOC:TermGenie]
synonym: "downregulation of PKR-like ER kinase signal transduction" EXACT [GOC:TermGenie]
synonym: "downregulation of UPR signaling by PERK stress sensor" EXACT [GOC:TermGenie]
synonym: "inhibition of endoplasmic reticulum unfolded protein response; PERK signaling" NARROW [GOC:TermGenie]
synonym: "inhibition of PERK branch of UPR" NARROW [GOC:TermGenie]
synonym: "inhibition of PERK signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "inhibition of PERK-mediated unfolded protein response" NARROW [GOC:TermGenie]
synonym: "inhibition of PKR-like ER kinase signal transduction" NARROW [GOC:TermGenie]
synonym: "inhibition of UPR signaling by PERK stress sensor" NARROW [GOC:TermGenie]
synonym: "negative regulation of EIF2AK3-mediated unfolded protein response" RELATED [HGNC:3255]
synonym: "negative regulation of endoplasmic reticulum unfolded protein response; PERK signaling" EXACT [GOC:TermGenie]
synonym: "negative regulation of PERK branch of UPR" EXACT [GOC:TermGenie]
synonym: "negative regulation of PERK signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "negative regulation of PKR-like ER kinase signal transduction" EXACT [GOC:TermGenie]
synonym: "negative regulation of UPR signaling by PERK stress sensor" EXACT [GOC:TermGenie]
is_a: GO:1900102 ! negative regulation of endoplasmic reticulum unfolded protein response
is_a: GO:1903897 ! regulation of PERK-mediated unfolded protein response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0036499 ! PERK-mediated unfolded protein response
relationship: negatively_regulates GO:0036499 ! PERK-mediated unfolded protein response
created_by: bf
creation_date: 2015-02-09T10:18:23Z

[Term]
id: GO:1903899
name: positive regulation of PERK-mediated unfolded protein response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the PERK-mediated unfolded protein response." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22013210]
synonym: "activation of endoplasmic reticulum unfolded protein response; PERK signaling" NARROW [GOC:TermGenie]
synonym: "activation of PERK branch of UPR" NARROW [GOC:TermGenie]
synonym: "activation of PERK signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "activation of PERK-mediated unfolded protein response" NARROW [GOC:TermGenie]
synonym: "activation of PKR-like ER kinase signal transduction" NARROW [GOC:TermGenie]
synonym: "activation of UPR signaling by PERK stress sensor" NARROW [GOC:TermGenie]
synonym: "positive regulation of EIF2AK3-mediated unfolded protein response" RELATED [HGNC:3255]
synonym: "positive regulation of endoplasmic reticulum unfolded protein response; PERK signaling" EXACT [GOC:TermGenie]
synonym: "positive regulation of PERK branch of UPR" EXACT [GOC:TermGenie]
synonym: "positive regulation of PERK signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "positive regulation of PKR-like ER kinase signal transduction" EXACT [GOC:TermGenie]
synonym: "positive regulation of UPR signaling by PERK stress sensor" EXACT [GOC:TermGenie]
synonym: "up regulation of endoplasmic reticulum unfolded protein response; PERK signaling" EXACT [GOC:TermGenie]
synonym: "up regulation of PERK branch of UPR" EXACT [GOC:TermGenie]
synonym: "up regulation of PERK signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "up regulation of PERK-mediated unfolded protein response" EXACT [GOC:TermGenie]
synonym: "up regulation of PKR-like ER kinase signal transduction" EXACT [GOC:TermGenie]
synonym: "up regulation of UPR signaling by PERK stress sensor" EXACT [GOC:TermGenie]
synonym: "up-regulation of endoplasmic reticulum unfolded protein response; PERK signaling" EXACT [GOC:TermGenie]
synonym: "up-regulation of PERK branch of UPR" EXACT [GOC:TermGenie]
synonym: "up-regulation of PERK signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "up-regulation of PERK-mediated unfolded protein response" EXACT [GOC:TermGenie]
synonym: "up-regulation of PKR-like ER kinase signal transduction" EXACT [GOC:TermGenie]
synonym: "up-regulation of UPR signaling by PERK stress sensor" EXACT [GOC:TermGenie]
synonym: "upregulation of endoplasmic reticulum unfolded protein response; PERK signaling" EXACT [GOC:TermGenie]
synonym: "upregulation of PERK branch of UPR" EXACT [GOC:TermGenie]
synonym: "upregulation of PERK signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie]
synonym: "upregulation of PERK-mediated unfolded protein response" EXACT [GOC:TermGenie]
synonym: "upregulation of PKR-like ER kinase signal transduction" EXACT [GOC:TermGenie]
synonym: "upregulation of UPR signaling by PERK stress sensor" EXACT [GOC:TermGenie]
is_a: GO:1900103 ! positive regulation of endoplasmic reticulum unfolded protein response
is_a: GO:1903897 ! regulation of PERK-mediated unfolded protein response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0036499 ! PERK-mediated unfolded protein response
relationship: positively_regulates GO:0036499 ! PERK-mediated unfolded protein response
created_by: bf
creation_date: 2015-02-09T10:18:32Z

[Term]
id: GO:1903900
name: regulation of viral life cycle
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of viral life cycle." [GO_REF:0000058, GOC:TermGenie, PMID:18005716]
synonym: "regulation of lytic viral life cycle" RELATED [GOC:TermGenie]
synonym: "regulation of viral assembly, maturation, egress, and release" NARROW [GOC:TermGenie]
synonym: "regulation of viral infectious cycle" RELATED [GOC:TermGenie]
synonym: "regulation of viral replication" RELATED [GOC:TermGenie]
is_a: GO:0050792 ! regulation of viral process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019058 ! viral life cycle
relationship: regulates GO:0019058 ! viral life cycle
created_by: pga
creation_date: 2015-02-09T10:22:07Z

[Term]
id: GO:1903901
name: negative regulation of viral life cycle
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of viral life cycle." [GO_REF:0000058, GOC:TermGenie, PMID:18005716]
synonym: "down regulation of lytic viral life cycle" RELATED [GOC:TermGenie]
synonym: "down regulation of viral assembly, maturation, egress, and release" NARROW [GOC:TermGenie]
synonym: "down regulation of viral infectious cycle" RELATED [GOC:TermGenie]
synonym: "down regulation of viral life cycle" EXACT [GOC:TermGenie]
synonym: "down regulation of viral replication" RELATED [GOC:TermGenie]
synonym: "down-regulation of lytic viral life cycle" RELATED [GOC:TermGenie]
synonym: "down-regulation of viral assembly, maturation, egress, and release" NARROW [GOC:TermGenie]
synonym: "down-regulation of viral infectious cycle" RELATED [GOC:TermGenie]
synonym: "down-regulation of viral life cycle" EXACT [GOC:TermGenie]
synonym: "down-regulation of viral replication" RELATED [GOC:TermGenie]
synonym: "downregulation of lytic viral life cycle" RELATED [GOC:TermGenie]
synonym: "downregulation of viral assembly, maturation, egress, and release" NARROW [GOC:TermGenie]
synonym: "downregulation of viral infectious cycle" RELATED [GOC:TermGenie]
synonym: "downregulation of viral life cycle" EXACT [GOC:TermGenie]
synonym: "downregulation of viral replication" RELATED [GOC:TermGenie]
synonym: "inhibition of lytic viral life cycle" RELATED [GOC:TermGenie]
synonym: "inhibition of viral assembly, maturation, egress, and release" NARROW [GOC:TermGenie]
synonym: "inhibition of viral infectious cycle" RELATED [GOC:TermGenie]
synonym: "inhibition of viral life cycle" NARROW [GOC:TermGenie]
synonym: "inhibition of viral replication" RELATED [GOC:TermGenie]
synonym: "negative regulation of lytic viral life cycle" RELATED [GOC:TermGenie]
synonym: "negative regulation of viral assembly, maturation, egress, and release" NARROW [GOC:TermGenie]
synonym: "negative regulation of viral infectious cycle" RELATED [GOC:TermGenie]
synonym: "negative regulation of viral replication" RELATED [GOC:TermGenie]
is_a: GO:0048525 ! negative regulation of viral process
is_a: GO:1903900 ! regulation of viral life cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019058 ! viral life cycle
relationship: negatively_regulates GO:0019058 ! viral life cycle
created_by: pga
creation_date: 2015-02-09T10:22:16Z

[Term]
id: GO:1903902
name: positive regulation of viral life cycle
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of viral life cycle." [GO_REF:0000058, GOC:TermGenie, PMID:18005716]
synonym: "activation of lytic viral life cycle" RELATED [GOC:TermGenie]
synonym: "activation of viral assembly, maturation, egress, and release" NARROW [GOC:TermGenie]
synonym: "activation of viral infectious cycle" RELATED [GOC:TermGenie]
synonym: "activation of viral life cycle" NARROW [GOC:TermGenie]
synonym: "activation of viral replication" RELATED [GOC:TermGenie]
synonym: "positive regulation of lytic viral life cycle" RELATED [GOC:TermGenie]
synonym: "positive regulation of viral assembly, maturation, egress, and release" NARROW [GOC:TermGenie]
synonym: "positive regulation of viral infectious cycle" RELATED [GOC:TermGenie]
synonym: "positive regulation of viral replication" RELATED [GOC:TermGenie]
synonym: "up regulation of lytic viral life cycle" RELATED [GOC:TermGenie]
synonym: "up regulation of viral assembly, maturation, egress, and release" NARROW [GOC:TermGenie]
synonym: "up regulation of viral infectious cycle" RELATED [GOC:TermGenie]
synonym: "up regulation of viral life cycle" EXACT [GOC:TermGenie]
synonym: "up regulation of viral replication" RELATED [GOC:TermGenie]
synonym: "up-regulation of lytic viral life cycle" RELATED [GOC:TermGenie]
synonym: "up-regulation of viral assembly, maturation, egress, and release" NARROW [GOC:TermGenie]
synonym: "up-regulation of viral infectious cycle" RELATED [GOC:TermGenie]
synonym: "up-regulation of viral life cycle" EXACT [GOC:TermGenie]
synonym: "up-regulation of viral replication" RELATED [GOC:TermGenie]
synonym: "upregulation of lytic viral life cycle" RELATED [GOC:TermGenie]
synonym: "upregulation of viral assembly, maturation, egress, and release" NARROW [GOC:TermGenie]
synonym: "upregulation of viral infectious cycle" RELATED [GOC:TermGenie]
synonym: "upregulation of viral life cycle" EXACT [GOC:TermGenie]
synonym: "upregulation of viral replication" RELATED [GOC:TermGenie]
is_a: GO:0048524 ! positive regulation of viral process
is_a: GO:1903900 ! regulation of viral life cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0019058 ! viral life cycle
relationship: positively_regulates GO:0019058 ! viral life cycle
created_by: pga
creation_date: 2015-02-09T10:22:25Z

[Term]
id: GO:1903903
name: regulation of establishment of T cell polarity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of establishment of T cell polarity." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248]
synonym: "regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie]
synonym: "regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "regulation of T cell polarization" EXACT [GOC:TermGenie]
synonym: "regulation of T lymphocyte polarization" EXACT [GOC:TermGenie]
synonym: "regulation of T-cell polarization" EXACT [GOC:TermGenie]
is_a: GO:0050863 ! regulation of T cell activation
is_a: GO:2000114 ! regulation of establishment of cell polarity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001768 ! establishment of T cell polarity
relationship: regulates GO:0001768 ! establishment of T cell polarity
created_by: als
creation_date: 2015-02-09T10:50:21Z

[Term]
id: GO:1903904
name: negative regulation of establishment of T cell polarity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of T cell polarity." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248]
synonym: "down regulation of establishment of T cell polarity" EXACT [GOC:TermGenie]
synonym: "down regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "down regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie]
synonym: "down regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "down regulation of T cell polarization" EXACT [GOC:TermGenie]
synonym: "down regulation of T lymphocyte polarization" EXACT [GOC:TermGenie]
synonym: "down regulation of T-cell polarization" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of T cell polarity" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "down-regulation of T cell polarization" EXACT [GOC:TermGenie]
synonym: "down-regulation of T lymphocyte polarization" EXACT [GOC:TermGenie]
synonym: "down-regulation of T-cell polarization" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of T cell polarity" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of T-cell polarity" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "downregulation of T cell polarization" EXACT [GOC:TermGenie]
synonym: "downregulation of T lymphocyte polarization" EXACT [GOC:TermGenie]
synonym: "downregulation of T-cell polarization" EXACT [GOC:TermGenie]
synonym: "inhibition of establishment of T cell polarity" NARROW [GOC:TermGenie]
synonym: "inhibition of establishment of T lymphocyte polarity" NARROW [GOC:TermGenie]
synonym: "inhibition of establishment of T-cell polarity" NARROW [GOC:TermGenie]
synonym: "inhibition of establishment of T-lymphocyte polarity" NARROW [GOC:TermGenie]
synonym: "inhibition of T cell polarization" NARROW [GOC:TermGenie]
synonym: "inhibition of T lymphocyte polarization" NARROW [GOC:TermGenie]
synonym: "inhibition of T-cell polarization" NARROW [GOC:TermGenie]
synonym: "negative regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "negative regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie]
synonym: "negative regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "negative regulation of T cell polarization" EXACT [GOC:TermGenie]
synonym: "negative regulation of T lymphocyte polarization" EXACT [GOC:TermGenie]
synonym: "negative regulation of T-cell polarization" EXACT [GOC:TermGenie]
is_a: GO:0050868 ! negative regulation of T cell activation
is_a: GO:1903903 ! regulation of establishment of T cell polarity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001768 ! establishment of T cell polarity
relationship: negatively_regulates GO:0001768 ! establishment of T cell polarity
created_by: als
creation_date: 2015-02-09T10:50:30Z

[Term]
id: GO:1903905
name: positive regulation of establishment of T cell polarity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment of T cell polarity." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248]
synonym: "activation of establishment of T cell polarity" NARROW [GOC:TermGenie]
synonym: "activation of establishment of T lymphocyte polarity" NARROW [GOC:TermGenie]
synonym: "activation of establishment of T-cell polarity" NARROW [GOC:TermGenie]
synonym: "activation of establishment of T-lymphocyte polarity" NARROW [GOC:TermGenie]
synonym: "activation of T cell polarization" NARROW [GOC:TermGenie]
synonym: "activation of T lymphocyte polarization" NARROW [GOC:TermGenie]
synonym: "activation of T-cell polarization" NARROW [GOC:TermGenie]
synonym: "positive regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "positive regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie]
synonym: "positive regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "positive regulation of T cell polarization" EXACT [GOC:TermGenie]
synonym: "positive regulation of T lymphocyte polarization" EXACT [GOC:TermGenie]
synonym: "positive regulation of T-cell polarization" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of T cell polarity" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "up regulation of T cell polarization" EXACT [GOC:TermGenie]
synonym: "up regulation of T lymphocyte polarization" EXACT [GOC:TermGenie]
synonym: "up regulation of T-cell polarization" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of T cell polarity" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "up-regulation of T cell polarization" EXACT [GOC:TermGenie]
synonym: "up-regulation of T lymphocyte polarization" EXACT [GOC:TermGenie]
synonym: "up-regulation of T-cell polarization" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of T cell polarity" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of T-cell polarity" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "upregulation of T cell polarization" EXACT [GOC:TermGenie]
synonym: "upregulation of T lymphocyte polarization" EXACT [GOC:TermGenie]
synonym: "upregulation of T-cell polarization" EXACT [GOC:TermGenie]
is_a: GO:0050870 ! positive regulation of T cell activation
is_a: GO:1903903 ! regulation of establishment of T cell polarity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001768 ! establishment of T cell polarity
relationship: positively_regulates GO:0001768 ! establishment of T cell polarity
created_by: als
creation_date: 2015-02-09T10:50:40Z

[Term]
id: GO:1903906
name: regulation of plasma membrane raft polarization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of plasma membrane raft polarization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248]
is_a: GO:0051128 ! regulation of cellular component organization
is_a: GO:0060341 ! regulation of cellular localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044858 ! plasma membrane raft polarization
relationship: regulates GO:0044858 ! plasma membrane raft polarization
created_by: als
creation_date: 2015-02-09T10:53:56Z

[Term]
id: GO:1903907
name: negative regulation of plasma membrane raft polarization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of plasma membrane raft polarization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248]
synonym: "down regulation of plasma membrane raft polarization" EXACT [GOC:TermGenie]
synonym: "down-regulation of plasma membrane raft polarization" EXACT [GOC:TermGenie]
synonym: "downregulation of plasma membrane raft polarization" EXACT [GOC:TermGenie]
synonym: "inhibition of plasma membrane raft polarization" NARROW [GOC:TermGenie]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1903906 ! regulation of plasma membrane raft polarization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044858 ! plasma membrane raft polarization
relationship: negatively_regulates GO:0044858 ! plasma membrane raft polarization
created_by: als
creation_date: 2015-02-09T10:54:05Z

[Term]
id: GO:1903908
name: positive regulation of plasma membrane raft polarization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of plasma membrane raft polarization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248]
synonym: "activation of plasma membrane raft polarization" NARROW [GOC:TermGenie]
synonym: "up regulation of plasma membrane raft polarization" EXACT [GOC:TermGenie]
synonym: "up-regulation of plasma membrane raft polarization" EXACT [GOC:TermGenie]
synonym: "upregulation of plasma membrane raft polarization" EXACT [GOC:TermGenie]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1903906 ! regulation of plasma membrane raft polarization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044858 ! plasma membrane raft polarization
relationship: positively_regulates GO:0044858 ! plasma membrane raft polarization
created_by: als
creation_date: 2015-02-09T10:54:15Z

[Term]
id: GO:1903909
name: regulation of receptor clustering
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of receptor clustering." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248]
is_a: GO:0051128 ! regulation of cellular component organization
is_a: GO:1903827 ! regulation of cellular protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043113 ! receptor clustering
relationship: regulates GO:0043113 ! receptor clustering
created_by: als
creation_date: 2015-02-09T10:56:33Z

[Term]
id: GO:1903910
name: negative regulation of receptor clustering
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of receptor clustering." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248]
synonym: "down regulation of receptor clustering" EXACT [GOC:TermGenie]
synonym: "down-regulation of receptor clustering" EXACT [GOC:TermGenie]
synonym: "downregulation of receptor clustering" EXACT [GOC:TermGenie]
synonym: "inhibition of receptor clustering" NARROW [GOC:TermGenie]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1903828 ! negative regulation of cellular protein localization
is_a: GO:1903909 ! regulation of receptor clustering
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043113 ! receptor clustering
relationship: negatively_regulates GO:0043113 ! receptor clustering
created_by: als
creation_date: 2015-02-09T10:56:42Z

[Term]
id: GO:1903911
name: positive regulation of receptor clustering
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of receptor clustering." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248]
synonym: "activation of receptor clustering" NARROW [GOC:TermGenie]
synonym: "up regulation of receptor clustering" EXACT [GOC:TermGenie]
synonym: "up-regulation of receptor clustering" EXACT [GOC:TermGenie]
synonym: "upregulation of receptor clustering" EXACT [GOC:TermGenie]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1903829 ! positive regulation of cellular protein localization
is_a: GO:1903909 ! regulation of receptor clustering
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043113 ! receptor clustering
relationship: positively_regulates GO:0043113 ! receptor clustering
created_by: als
creation_date: 2015-02-09T10:56:51Z

[Term]
id: GO:1903912
name: negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of endoplasmic reticulum stress-induced eiF2alpha phosphorylation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:16835242]
synonym: "down regulation of eiF2alpha phosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "down regulation of eiF2alpha phosphorylation in response to ER stress" EXACT [GOC:TermGenie]
synonym: "down regulation of regulation of translation initiation by eiF2alpha phosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of eiF2alpha phosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of eiF2alpha phosphorylation in response to ER stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of regulation of translation initiation by eiF2alpha phosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "downregulation of eiF2alpha phosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "downregulation of eiF2alpha phosphorylation in response to ER stress" EXACT [GOC:TermGenie]
synonym: "downregulation of regulation of translation initiation by eiF2alpha phosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "inhibition of eiF2alpha phosphorylation in response to endoplasmic reticulum stress" NARROW [GOC:TermGenie]
synonym: "inhibition of eiF2alpha phosphorylation in response to ER stress" NARROW [GOC:TermGenie]
synonym: "inhibition of regulation of translation initiation by eiF2alpha phosphorylation in response to endoplasmic reticulum stress" NARROW [GOC:TermGenie]
synonym: "negative regulation of eiF2alpha phosphorylation in response to endoplasmic reticulum stress" EXACT []
synonym: "negative regulation of eiF2alpha phosphorylation in response to ER stress" EXACT [GOC:TermGenie]
synonym: "negative regulation of ER stress-induced eIF2 alpha phosphorylation" EXACT [GOC:bf]
synonym: "negative regulation of regulation of translation initiation by eiF2alpha phosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
is_a: GO:0001933 ! negative regulation of protein phosphorylation
is_a: GO:0006446 ! regulation of translational initiation
is_a: GO:1903573 ! negative regulation of response to endoplasmic reticulum stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0036492 ! eiF2alpha phosphorylation in response to endoplasmic reticulum stress
relationship: negatively_regulates GO:0036492 ! eiF2alpha phosphorylation in response to endoplasmic reticulum stress
created_by: bf
creation_date: 2015-02-09T10:58:55Z

[Term]
id: GO:1903913
name: regulation of fusion of virus membrane with host plasma membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fusion of virus membrane with host plasma membrane." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248]
synonym: "regulation of viral entry into host cell via membrane fusion with the plasma membrane" RELATED [GOC:TermGenie]
synonym: "regulation of viral envelope fusion" BROAD [GOC:TermGenie]
synonym: "regulation of viral envelope fusion with host cell membrane" EXACT [GOC:TermGenie]
synonym: "regulation of viral envelope fusion with host membrane" EXACT [GOC:TermGenie]
synonym: "regulation of viral envelope fusion with host plasma membrane" EXACT [GOC:TermGenie]
synonym: "regulation of viral penetration via membrane fusion" EXACT [GOC:TermGenie]
synonym: "regulation of viral-cell fusion molecule activity" RELATED [GOC:TermGenie]
is_a: GO:0046596 ! regulation of viral entry into host cell
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019064 ! fusion of virus membrane with host plasma membrane
relationship: regulates GO:0019064 ! fusion of virus membrane with host plasma membrane
created_by: als
creation_date: 2015-02-09T11:13:19Z

[Term]
id: GO:1903914
name: negative regulation of fusion of virus membrane with host plasma membrane
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of fusion of virus membrane with host plasma membrane." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248]
synonym: "down regulation of fusion of virus membrane with host plasma membrane" EXACT [GOC:TermGenie]
synonym: "down regulation of viral entry into host cell via membrane fusion with the plasma membrane" RELATED [GOC:TermGenie]
synonym: "down regulation of viral envelope fusion with host cell membrane" EXACT [GOC:TermGenie]
synonym: "down regulation of viral envelope fusion with host membrane" EXACT [GOC:TermGenie]
synonym: "down regulation of viral envelope fusion with host plasma membrane" EXACT [GOC:TermGenie]
synonym: "down regulation of viral penetration via membrane fusion" EXACT [GOC:TermGenie]
synonym: "down regulation of viral-cell fusion molecule activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of fusion of virus membrane with host plasma membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of viral entry into host cell via membrane fusion with the plasma membrane" RELATED [GOC:TermGenie]
synonym: "down-regulation of viral envelope fusion with host cell membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of viral envelope fusion with host membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of viral envelope fusion with host plasma membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of viral penetration via membrane fusion" EXACT [GOC:TermGenie]
synonym: "down-regulation of viral-cell fusion molecule activity" RELATED [GOC:TermGenie]
synonym: "downregulation of fusion of virus membrane with host plasma membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of viral entry into host cell via membrane fusion with the plasma membrane" RELATED [GOC:TermGenie]
synonym: "downregulation of viral envelope fusion with host cell membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of viral envelope fusion with host membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of viral envelope fusion with host plasma membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of viral penetration via membrane fusion" EXACT [GOC:TermGenie]
synonym: "downregulation of viral-cell fusion molecule activity" RELATED [GOC:TermGenie]
synonym: "inhibition of fusion of virus membrane with host plasma membrane" NARROW [GOC:TermGenie]
synonym: "inhibition of viral entry into host cell via membrane fusion with the plasma membrane" RELATED [GOC:TermGenie]
synonym: "inhibition of viral envelope fusion with host cell membrane" NARROW [GOC:TermGenie]
synonym: "inhibition of viral envelope fusion with host membrane" NARROW [GOC:TermGenie]
synonym: "inhibition of viral envelope fusion with host plasma membrane" NARROW [GOC:TermGenie]
synonym: "inhibition of viral penetration via membrane fusion" NARROW [GOC:TermGenie]
synonym: "inhibition of viral-cell fusion molecule activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of viral entry into host cell via membrane fusion with the plasma membrane" RELATED [GOC:TermGenie]
synonym: "negative regulation of viral envelope fusion with host cell membrane" EXACT [GOC:TermGenie]
synonym: "negative regulation of viral envelope fusion with host membrane" EXACT [GOC:TermGenie]
synonym: "negative regulation of viral envelope fusion with host plasma membrane" EXACT [GOC:TermGenie]
synonym: "negative regulation of viral penetration via membrane fusion" EXACT [GOC:TermGenie]
synonym: "negative regulation of viral-cell fusion molecule activity" RELATED [GOC:TermGenie]
is_a: GO:0046597 ! negative regulation of viral entry into host cell
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1903913 ! regulation of fusion of virus membrane with host plasma membrane
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019064 ! fusion of virus membrane with host plasma membrane
relationship: negatively_regulates GO:0019064 ! fusion of virus membrane with host plasma membrane
created_by: als
creation_date: 2015-02-09T11:13:32Z

[Term]
id: GO:1903915
name: positive regulation of fusion of virus membrane with host plasma membrane
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of fusion of virus membrane with host plasma membrane." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248]
synonym: "activation of fusion of virus membrane with host plasma membrane" NARROW [GOC:TermGenie]
synonym: "activation of viral entry into host cell via membrane fusion with the plasma membrane" RELATED [GOC:TermGenie]
synonym: "activation of viral envelope fusion with host cell membrane" NARROW [GOC:TermGenie]
synonym: "activation of viral envelope fusion with host membrane" NARROW [GOC:TermGenie]
synonym: "activation of viral envelope fusion with host plasma membrane" NARROW [GOC:TermGenie]
synonym: "activation of viral penetration via membrane fusion" NARROW [GOC:TermGenie]
synonym: "activation of viral-cell fusion molecule activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of viral entry into host cell via membrane fusion with the plasma membrane" RELATED [GOC:TermGenie]
synonym: "positive regulation of viral envelope fusion with host cell membrane" EXACT [GOC:TermGenie]
synonym: "positive regulation of viral envelope fusion with host membrane" EXACT [GOC:TermGenie]
synonym: "positive regulation of viral envelope fusion with host plasma membrane" EXACT [GOC:TermGenie]
synonym: "positive regulation of viral penetration via membrane fusion" EXACT [GOC:TermGenie]
synonym: "positive regulation of viral-cell fusion molecule activity" RELATED [GOC:TermGenie]
synonym: "up regulation of fusion of virus membrane with host plasma membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of viral entry into host cell via membrane fusion with the plasma membrane" RELATED [GOC:TermGenie]
synonym: "up regulation of viral envelope fusion with host cell membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of viral envelope fusion with host membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of viral envelope fusion with host plasma membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of viral penetration via membrane fusion" EXACT [GOC:TermGenie]
synonym: "up regulation of viral-cell fusion molecule activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of fusion of virus membrane with host plasma membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of viral entry into host cell via membrane fusion with the plasma membrane" RELATED [GOC:TermGenie]
synonym: "up-regulation of viral envelope fusion with host cell membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of viral envelope fusion with host membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of viral envelope fusion with host plasma membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of viral penetration via membrane fusion" EXACT [GOC:TermGenie]
synonym: "up-regulation of viral-cell fusion molecule activity" RELATED [GOC:TermGenie]
synonym: "upregulation of fusion of virus membrane with host plasma membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of viral entry into host cell via membrane fusion with the plasma membrane" RELATED [GOC:TermGenie]
synonym: "upregulation of viral envelope fusion with host cell membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of viral envelope fusion with host membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of viral envelope fusion with host plasma membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of viral penetration via membrane fusion" EXACT [GOC:TermGenie]
synonym: "upregulation of viral-cell fusion molecule activity" RELATED [GOC:TermGenie]
is_a: GO:0046598 ! positive regulation of viral entry into host cell
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1903913 ! regulation of fusion of virus membrane with host plasma membrane
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0019064 ! fusion of virus membrane with host plasma membrane
relationship: positively_regulates GO:0019064 ! fusion of virus membrane with host plasma membrane
created_by: als
creation_date: 2015-02-09T11:13:41Z

[Term]
id: GO:1903916
name: regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endoplasmic reticulum stress-induced eIF2alpha dephosphorylation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "regulation of eIF2alpha dephosphorylation in response to endoplasmic reticulum stress" EXACT []
synonym: "regulation of eIF2alpha dephosphorylation in response to ER stress" EXACT [GOC:TermGenie]
synonym: "regulation of ER stress-induced eIF2 alpha dephosphorylation" EXACT [GOC:bf]
synonym: "regulation of regulation of translation initiation by eIF2alpha dephosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
is_a: GO:0006446 ! regulation of translational initiation
is_a: GO:0035304 ! regulation of protein dephosphorylation
is_a: GO:0080135 ! regulation of cellular response to stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0036497 ! eIF2alpha dephosphorylation in response to endoplasmic reticulum stress
relationship: regulates GO:0036497 ! eIF2alpha dephosphorylation in response to endoplasmic reticulum stress
created_by: bf
creation_date: 2015-02-09T11:18:14Z

[Term]
id: GO:1903917
name: positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endoplasmic reticulum stress-induced eIF2alpha dephosphorylation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11381086]
synonym: "activation of eIF2alpha dephosphorylation in response to endoplasmic reticulum stress" NARROW [GOC:TermGenie]
synonym: "activation of eIF2alpha dephosphorylation in response to ER stress" NARROW [GOC:TermGenie]
synonym: "activation of regulation of translation initiation by eIF2alpha dephosphorylation in response to endoplasmic reticulum stress" NARROW [GOC:TermGenie]
synonym: "positive regulation of eIF2alpha dephosphorylation in response to endoplasmic reticulum stress" RELATED []
synonym: "positive regulation of eIF2alpha dephosphorylation in response to ER stress" EXACT [GOC:TermGenie]
synonym: "positive regulation of ER stress-induced eIF2 alpha dephosphorylation" EXACT [GOC:bf]
synonym: "positive regulation of regulation of translation initiation by eIF2alpha dephosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "up regulation of eIF2alpha dephosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "up regulation of eIF2alpha dephosphorylation in response to ER stress" EXACT [GOC:TermGenie]
synonym: "up regulation of regulation of translation initiation by eIF2alpha dephosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of eIF2alpha dephosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of eIF2alpha dephosphorylation in response to ER stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of regulation of translation initiation by eIF2alpha dephosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "upregulation of eIF2alpha dephosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
synonym: "upregulation of eIF2alpha dephosphorylation in response to ER stress" EXACT [GOC:TermGenie]
synonym: "upregulation of regulation of translation initiation by eIF2alpha dephosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie]
is_a: GO:0035307 ! positive regulation of protein dephosphorylation
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1903916 ! regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0036497 ! eIF2alpha dephosphorylation in response to endoplasmic reticulum stress
relationship: positively_regulates GO:0036497 ! eIF2alpha dephosphorylation in response to endoplasmic reticulum stress
created_by: bf
creation_date: 2015-02-09T11:18:24Z

[Term]
id: GO:1903918
name: regulation of actin filament severing
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of actin filament severing." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23325791]
synonym: "regulation of actin filament severing activity" RELATED [GOC:TermGenie]
synonym: "regulation of barbed-end actin capping/severing activity" RELATED [GOC:TermGenie]
synonym: "regulation of F-actin severing" EXACT [GOC:TermGenie]
is_a: GO:0032970 ! regulation of actin filament-based process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051014 ! actin filament severing
relationship: regulates GO:0051014 ! actin filament severing
created_by: als
creation_date: 2015-02-10T11:01:21Z

[Term]
id: GO:1903919
name: negative regulation of actin filament severing
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of actin filament severing." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23325791]
synonym: "down regulation of actin filament severing" EXACT [GOC:TermGenie]
synonym: "down regulation of actin filament severing activity" RELATED [GOC:TermGenie]
synonym: "down regulation of barbed-end actin capping/severing activity" RELATED [GOC:TermGenie]
synonym: "down regulation of F-actin severing" EXACT [GOC:TermGenie]
synonym: "down-regulation of actin filament severing" EXACT [GOC:TermGenie]
synonym: "down-regulation of actin filament severing activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of barbed-end actin capping/severing activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of F-actin severing" EXACT [GOC:TermGenie]
synonym: "downregulation of actin filament severing" EXACT [GOC:TermGenie]
synonym: "downregulation of actin filament severing activity" RELATED [GOC:TermGenie]
synonym: "downregulation of barbed-end actin capping/severing activity" RELATED [GOC:TermGenie]
synonym: "downregulation of F-actin severing" EXACT [GOC:TermGenie]
synonym: "inhibition of actin filament severing" NARROW [GOC:TermGenie]
synonym: "inhibition of actin filament severing activity" RELATED [GOC:TermGenie]
synonym: "inhibition of barbed-end actin capping/severing activity" RELATED [GOC:TermGenie]
synonym: "inhibition of F-actin severing" NARROW [GOC:TermGenie]
synonym: "negative regulation of actin filament severing activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of barbed-end actin capping/severing activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of F-actin severing" EXACT [GOC:TermGenie]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:1903918 ! regulation of actin filament severing
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051014 ! actin filament severing
relationship: negatively_regulates GO:0051014 ! actin filament severing
created_by: als
creation_date: 2015-02-10T11:01:31Z

[Term]
id: GO:1903920
name: positive regulation of actin filament severing
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of actin filament severing." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23325791]
synonym: "activation of actin filament severing" NARROW [GOC:TermGenie]
synonym: "activation of actin filament severing activity" RELATED [GOC:TermGenie]
synonym: "activation of barbed-end actin capping/severing activity" RELATED [GOC:TermGenie]
synonym: "activation of F-actin severing" NARROW [GOC:TermGenie]
synonym: "positive regulation of actin filament severing activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of barbed-end actin capping/severing activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of F-actin severing" EXACT [GOC:TermGenie]
synonym: "up regulation of actin filament severing" EXACT [GOC:TermGenie]
synonym: "up regulation of actin filament severing activity" RELATED [GOC:TermGenie]
synonym: "up regulation of barbed-end actin capping/severing activity" RELATED [GOC:TermGenie]
synonym: "up regulation of F-actin severing" EXACT [GOC:TermGenie]
synonym: "up-regulation of actin filament severing" EXACT [GOC:TermGenie]
synonym: "up-regulation of actin filament severing activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of barbed-end actin capping/severing activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of F-actin severing" EXACT [GOC:TermGenie]
synonym: "upregulation of actin filament severing" EXACT [GOC:TermGenie]
synonym: "upregulation of actin filament severing activity" RELATED [GOC:TermGenie]
synonym: "upregulation of barbed-end actin capping/severing activity" RELATED [GOC:TermGenie]
synonym: "upregulation of F-actin severing" EXACT [GOC:TermGenie]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:1903918 ! regulation of actin filament severing
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051014 ! actin filament severing
relationship: positively_regulates GO:0051014 ! actin filament severing
created_by: als
creation_date: 2015-02-10T11:01:40Z

[Term]
id: GO:1903921
name: regulation of protein processing in phagocytic vesicle
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein processing in phagocytic vesicle." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23325791]
synonym: "regulation of peptidolysis during protein maturation in phagocytic vesicle" RELATED [GOC:TermGenie]
synonym: "regulation of peptidolysis during protein maturation in phagosome" RELATED [GOC:TermGenie]
synonym: "regulation of protein maturation by peptide bond cleavage in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "regulation of protein maturation by peptide bond cleavage in phagosome" EXACT [GOC:TermGenie]
synonym: "regulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "regulation of protein maturation by peptide bond hydrolysis in phagosome" EXACT [GOC:TermGenie]
synonym: "regulation of protein maturation by proteolysis in phagocytic vesicle" RELATED [GOC:TermGenie]
synonym: "regulation of protein maturation by proteolysis in phagosome" RELATED [GOC:TermGenie]
synonym: "regulation of protein processing in phagosome" EXACT [GOC:TermGenie]
is_a: GO:0070613 ! regulation of protein processing
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900756 ! protein processing in phagocytic vesicle
relationship: regulates GO:1900756 ! protein processing in phagocytic vesicle
created_by: als
creation_date: 2015-02-10T11:16:54Z

[Term]
id: GO:1903922
name: negative regulation of protein processing in phagocytic vesicle
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein processing in phagocytic vesicle." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23325791]
synonym: "down regulation of peptidolysis during protein maturation in phagocytic vesicle" RELATED [GOC:TermGenie]
synonym: "down regulation of peptidolysis during protein maturation in phagosome" RELATED [GOC:TermGenie]
synonym: "down regulation of protein maturation by peptide bond cleavage in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "down regulation of protein maturation by peptide bond cleavage in phagosome" EXACT [GOC:TermGenie]
synonym: "down regulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "down regulation of protein maturation by peptide bond hydrolysis in phagosome" EXACT [GOC:TermGenie]
synonym: "down regulation of protein maturation by proteolysis in phagocytic vesicle" RELATED [GOC:TermGenie]
synonym: "down regulation of protein maturation by proteolysis in phagosome" RELATED [GOC:TermGenie]
synonym: "down regulation of protein processing in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "down regulation of protein processing in phagosome" EXACT [GOC:TermGenie]
synonym: "down-regulation of peptidolysis during protein maturation in phagocytic vesicle" RELATED [GOC:TermGenie]
synonym: "down-regulation of peptidolysis during protein maturation in phagosome" RELATED [GOC:TermGenie]
synonym: "down-regulation of protein maturation by peptide bond cleavage in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein maturation by peptide bond cleavage in phagosome" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein maturation by peptide bond hydrolysis in phagosome" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein maturation by proteolysis in phagocytic vesicle" RELATED [GOC:TermGenie]
synonym: "down-regulation of protein maturation by proteolysis in phagosome" RELATED [GOC:TermGenie]
synonym: "down-regulation of protein processing in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein processing in phagosome" EXACT [GOC:TermGenie]
synonym: "downregulation of peptidolysis during protein maturation in phagocytic vesicle" RELATED [GOC:TermGenie]
synonym: "downregulation of peptidolysis during protein maturation in phagosome" RELATED [GOC:TermGenie]
synonym: "downregulation of protein maturation by peptide bond cleavage in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "downregulation of protein maturation by peptide bond cleavage in phagosome" EXACT [GOC:TermGenie]
synonym: "downregulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "downregulation of protein maturation by peptide bond hydrolysis in phagosome" EXACT [GOC:TermGenie]
synonym: "downregulation of protein maturation by proteolysis in phagocytic vesicle" RELATED [GOC:TermGenie]
synonym: "downregulation of protein maturation by proteolysis in phagosome" RELATED [GOC:TermGenie]
synonym: "downregulation of protein processing in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "downregulation of protein processing in phagosome" EXACT [GOC:TermGenie]
synonym: "inhibition of peptidolysis during protein maturation in phagocytic vesicle" RELATED [GOC:TermGenie]
synonym: "inhibition of peptidolysis during protein maturation in phagosome" RELATED [GOC:TermGenie]
synonym: "inhibition of protein maturation by peptide bond cleavage in phagocytic vesicle" NARROW [GOC:TermGenie]
synonym: "inhibition of protein maturation by peptide bond cleavage in phagosome" NARROW [GOC:TermGenie]
synonym: "inhibition of protein maturation by peptide bond hydrolysis in phagocytic vesicle" NARROW [GOC:TermGenie]
synonym: "inhibition of protein maturation by peptide bond hydrolysis in phagosome" NARROW [GOC:TermGenie]
synonym: "inhibition of protein maturation by proteolysis in phagocytic vesicle" RELATED [GOC:TermGenie]
synonym: "inhibition of protein maturation by proteolysis in phagosome" RELATED [GOC:TermGenie]
synonym: "inhibition of protein processing in phagocytic vesicle" NARROW [GOC:TermGenie]
synonym: "inhibition of protein processing in phagosome" NARROW [GOC:TermGenie]
synonym: "negative regulation of peptidolysis during protein maturation in phagocytic vesicle" RELATED [GOC:TermGenie]
synonym: "negative regulation of peptidolysis during protein maturation in phagosome" RELATED [GOC:TermGenie]
synonym: "negative regulation of protein maturation by peptide bond cleavage in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein maturation by peptide bond cleavage in phagosome" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein maturation by peptide bond hydrolysis in phagosome" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein maturation by proteolysis in phagocytic vesicle" RELATED [GOC:TermGenie]
synonym: "negative regulation of protein maturation by proteolysis in phagosome" RELATED [GOC:TermGenie]
synonym: "negative regulation of protein processing in phagosome" EXACT [GOC:TermGenie]
is_a: GO:0010955 ! negative regulation of protein processing
is_a: GO:1903921 ! regulation of protein processing in phagocytic vesicle
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900756 ! protein processing in phagocytic vesicle
relationship: negatively_regulates GO:1900756 ! protein processing in phagocytic vesicle
created_by: als
creation_date: 2015-02-10T11:17:05Z

[Term]
id: GO:1903923
name: positive regulation of protein processing in phagocytic vesicle
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein processing in phagocytic vesicle." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23325791]
synonym: "activation of peptidolysis during protein maturation in phagocytic vesicle" RELATED [GOC:TermGenie]
synonym: "activation of peptidolysis during protein maturation in phagosome" RELATED [GOC:TermGenie]
synonym: "activation of protein maturation by peptide bond cleavage in phagocytic vesicle" NARROW [GOC:TermGenie]
synonym: "activation of protein maturation by peptide bond cleavage in phagosome" NARROW [GOC:TermGenie]
synonym: "activation of protein maturation by peptide bond hydrolysis in phagocytic vesicle" NARROW [GOC:TermGenie]
synonym: "activation of protein maturation by peptide bond hydrolysis in phagosome" NARROW [GOC:TermGenie]
synonym: "activation of protein maturation by proteolysis in phagocytic vesicle" RELATED [GOC:TermGenie]
synonym: "activation of protein maturation by proteolysis in phagosome" RELATED [GOC:TermGenie]
synonym: "activation of protein processing in phagocytic vesicle" NARROW [GOC:TermGenie]
synonym: "activation of protein processing in phagosome" NARROW [GOC:TermGenie]
synonym: "positive regulation of peptidolysis during protein maturation in phagocytic vesicle" RELATED [GOC:TermGenie]
synonym: "positive regulation of peptidolysis during protein maturation in phagosome" RELATED [GOC:TermGenie]
synonym: "positive regulation of protein maturation by peptide bond cleavage in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein maturation by peptide bond cleavage in phagosome" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein maturation by peptide bond hydrolysis in phagosome" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein maturation by proteolysis in phagocytic vesicle" RELATED [GOC:TermGenie]
synonym: "positive regulation of protein maturation by proteolysis in phagosome" RELATED [GOC:TermGenie]
synonym: "positive regulation of protein processing in phagosome" EXACT [GOC:TermGenie]
synonym: "up regulation of peptidolysis during protein maturation in phagocytic vesicle" RELATED [GOC:TermGenie]
synonym: "up regulation of peptidolysis during protein maturation in phagosome" RELATED [GOC:TermGenie]
synonym: "up regulation of protein maturation by peptide bond cleavage in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "up regulation of protein maturation by peptide bond cleavage in phagosome" EXACT [GOC:TermGenie]
synonym: "up regulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "up regulation of protein maturation by peptide bond hydrolysis in phagosome" EXACT [GOC:TermGenie]
synonym: "up regulation of protein maturation by proteolysis in phagocytic vesicle" RELATED [GOC:TermGenie]
synonym: "up regulation of protein maturation by proteolysis in phagosome" RELATED [GOC:TermGenie]
synonym: "up regulation of protein processing in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "up regulation of protein processing in phagosome" EXACT [GOC:TermGenie]
synonym: "up-regulation of peptidolysis during protein maturation in phagocytic vesicle" RELATED [GOC:TermGenie]
synonym: "up-regulation of peptidolysis during protein maturation in phagosome" RELATED [GOC:TermGenie]
synonym: "up-regulation of protein maturation by peptide bond cleavage in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein maturation by peptide bond cleavage in phagosome" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein maturation by peptide bond hydrolysis in phagosome" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein maturation by proteolysis in phagocytic vesicle" RELATED [GOC:TermGenie]
synonym: "up-regulation of protein maturation by proteolysis in phagosome" RELATED [GOC:TermGenie]
synonym: "up-regulation of protein processing in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein processing in phagosome" EXACT [GOC:TermGenie]
synonym: "upregulation of peptidolysis during protein maturation in phagocytic vesicle" RELATED [GOC:TermGenie]
synonym: "upregulation of peptidolysis during protein maturation in phagosome" RELATED [GOC:TermGenie]
synonym: "upregulation of protein maturation by peptide bond cleavage in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "upregulation of protein maturation by peptide bond cleavage in phagosome" EXACT [GOC:TermGenie]
synonym: "upregulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "upregulation of protein maturation by peptide bond hydrolysis in phagosome" EXACT [GOC:TermGenie]
synonym: "upregulation of protein maturation by proteolysis in phagocytic vesicle" RELATED [GOC:TermGenie]
synonym: "upregulation of protein maturation by proteolysis in phagosome" RELATED [GOC:TermGenie]
synonym: "upregulation of protein processing in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "upregulation of protein processing in phagosome" EXACT [GOC:TermGenie]
is_a: GO:0010954 ! positive regulation of protein processing
is_a: GO:1903921 ! regulation of protein processing in phagocytic vesicle
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900756 ! protein processing in phagocytic vesicle
relationship: positively_regulates GO:1900756 ! protein processing in phagocytic vesicle
created_by: als
creation_date: 2015-02-10T11:17:14Z

[Term]
id: GO:1903924
name: estradiol binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with estradiol." [GO_REF:0000067, GOC:TermGenie, PMID:9048584]
is_a: GO:0005496 ! steroid binding
is_a: GO:0043178 ! alcohol binding
created_by: sl
creation_date: 2015-02-11T00:11:34Z

[Term]
id: GO:1903925
name: response to bisphenol A
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bisphenol A stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22957036]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: sl
creation_date: 2015-02-11T00:16:46Z

[Term]
id: GO:1903926
name: cellular response to bisphenol A
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bisphenol A stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22957036]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1903925 ! response to bisphenol A
created_by: sl
creation_date: 2015-02-11T00:17:04Z

[Term]
id: GO:1903927
name: response to cyanide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyanide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21854848]
is_a: GO:0001101 ! response to acid chemical
is_a: GO:0010033 ! response to organic substance
created_by: sl
creation_date: 2015-02-11T19:04:19Z

[Term]
id: GO:1903928
name: cellular response to cyanide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyanide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21854848]
is_a: GO:0071229 ! cellular response to acid chemical
is_a: GO:1903927 ! response to cyanide
created_by: sl
creation_date: 2015-02-11T19:04:28Z

[Term]
id: GO:1903929
name: primary palate development
namespace: biological_process
def: "The process whose specific outcome is the progression of a primary palate over time, from its formation to the mature structure." [GO_REF:0000094, GOC:mgi_curators, GOC:TermGenie, PMID:24644145, PMID:25504820]
synonym: "palatum primarium development" RELATED [GOC:TermGenie]
synonym: "primary palate process development" EXACT [GOC:TermGenie]
synonym: "primitive palate development" RELATED [GOC:TermGenie]
synonym: "processus palatinus medianus development" RELATED [GOC:TermGenie]
is_a: GO:0060021 ! palate development
created_by: cynthia.smith
creation_date: 2015-02-11T22:42:38Z

[Term]
id: GO:1903930
name: regulation of pyrimidine-containing compound salvage
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pyrimidine-containing compound salvage." [GO_REF:0000058, GOC:TermGenie, PMID:23695302]
synonym: "regulation of pyrimidine salvage" RELATED [GOC:TermGenie]
is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008655 ! pyrimidine-containing compound salvage
relationship: regulates GO:0008655 ! pyrimidine-containing compound salvage
created_by: al
creation_date: 2015-02-12T14:09:05Z

[Term]
id: GO:1903931
name: positive regulation of pyrimidine-containing compound salvage
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pyrimidine-containing compound salvage." [GO_REF:0000058, GOC:TermGenie, PMID:23695302]
synonym: "activation of pyrimidine salvage" RELATED [GOC:TermGenie]
synonym: "activation of pyrimidine-containing compound salvage" NARROW [GOC:TermGenie]
synonym: "positive regulation of pyrimidine salvage" RELATED [GOC:TermGenie]
synonym: "up regulation of pyrimidine salvage" RELATED [GOC:TermGenie]
synonym: "up regulation of pyrimidine-containing compound salvage" EXACT [GOC:TermGenie]
synonym: "up-regulation of pyrimidine salvage" RELATED [GOC:TermGenie]
synonym: "up-regulation of pyrimidine-containing compound salvage" EXACT [GOC:TermGenie]
synonym: "upregulation of pyrimidine salvage" RELATED [GOC:TermGenie]
synonym: "upregulation of pyrimidine-containing compound salvage" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process
is_a: GO:1903930 ! regulation of pyrimidine-containing compound salvage
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008655 ! pyrimidine-containing compound salvage
relationship: positively_regulates GO:0008655 ! pyrimidine-containing compound salvage
created_by: al
creation_date: 2015-02-12T14:09:15Z

[Term]
id: GO:1903932
name: regulation of DNA primase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA primase activity." [GO_REF:0000059, GOC:TermGenie, PMID:14766746]
is_a: GO:0051338 ! regulation of transferase activity
is_a: GO:0090329 ! regulation of DNA-dependent DNA replication
is_a: GO:2001141 ! regulation of RNA biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003896 ! DNA primase activity
relationship: regulates GO:0003896 ! DNA primase activity
created_by: mah
creation_date: 2015-02-12T14:28:26Z

[Term]
id: GO:1903933
name: negative regulation of DNA primase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA primase activity." [GO_REF:0000059, GOC:TermGenie, PMID:14766746]
synonym: "down regulation of DNA primase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA primase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA primase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of DNA primase activity" NARROW [GOC:TermGenie]
is_a: GO:0051348 ! negative regulation of transferase activity
is_a: GO:1902679 ! negative regulation of RNA biosynthetic process
is_a: GO:1903932 ! regulation of DNA primase activity
is_a: GO:2000104 ! negative regulation of DNA-dependent DNA replication
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003896 ! DNA primase activity
relationship: negatively_regulates GO:0003896 ! DNA primase activity
created_by: mah
creation_date: 2015-02-12T14:28:36Z

[Term]
id: GO:1903934
name: positive regulation of DNA primase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA primase activity." [GO_REF:0000059, GOC:TermGenie, PMID:14766746]
synonym: "activation of DNA primase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of DNA primase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA primase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA primase activity" EXACT [GOC:TermGenie]
is_a: GO:0051347 ! positive regulation of transferase activity
is_a: GO:1902680 ! positive regulation of RNA biosynthetic process
is_a: GO:1903932 ! regulation of DNA primase activity
is_a: GO:2000105 ! positive regulation of DNA-dependent DNA replication
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003896 ! DNA primase activity
relationship: positively_regulates GO:0003896 ! DNA primase activity
created_by: mah
creation_date: 2015-02-12T14:28:45Z

[Term]
id: GO:1903935
name: response to sodium arsenite
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium arsenite stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18674524]
is_a: GO:0010035 ! response to inorganic substance
is_a: GO:0046685 ! response to arsenic-containing substance
is_a: GO:1902074 ! response to salt
created_by: sl
creation_date: 2015-02-12T20:54:33Z

[Term]
id: GO:1903936
name: cellular response to sodium arsenite
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium arsenite stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18674524]
is_a: GO:0071243 ! cellular response to arsenic-containing substance
is_a: GO:1902075 ! cellular response to salt
is_a: GO:1903935 ! response to sodium arsenite
created_by: sl
creation_date: 2015-02-12T20:54:53Z

[Term]
id: GO:1903937
name: response to acrylamide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acrylamide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16292499]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: sl
creation_date: 2015-02-12T22:00:24Z

[Term]
id: GO:1903938
name: cellular response to acrylamide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acrylamide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16292499]
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1903937 ! response to acrylamide
created_by: sl
creation_date: 2015-02-12T22:00:34Z

[Term]
id: GO:1903939
name: regulation of TORC2 signaling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of TORC2 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:24247430]
synonym: "regulation of TORC2 signal transduction" EXACT [GOC:TermGenie]
is_a: GO:0032006 ! regulation of TOR signaling
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0038203 ! TORC2 signaling
relationship: regulates GO:0038203 ! TORC2 signaling
created_by: al
creation_date: 2015-02-16T18:28:39Z

[Term]
id: GO:1903940
name: negative regulation of TORC2 signaling
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of TORC2 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:24247430]
synonym: "down regulation of TORC2 signal transduction" EXACT [GOC:TermGenie]
synonym: "down regulation of TORC2 signaling" EXACT [GOC:TermGenie]
synonym: "down-regulation of TORC2 signal transduction" EXACT [GOC:TermGenie]
synonym: "down-regulation of TORC2 signaling" EXACT [GOC:TermGenie]
synonym: "downregulation of TORC2 signal transduction" EXACT [GOC:TermGenie]
synonym: "downregulation of TORC2 signaling" EXACT [GOC:TermGenie]
synonym: "inhibition of TORC2 signal transduction" NARROW [GOC:TermGenie]
synonym: "inhibition of TORC2 signaling" NARROW [GOC:TermGenie]
synonym: "negative regulation of TORC2 signal transduction" EXACT [GOC:TermGenie]
is_a: GO:0032007 ! negative regulation of TOR signaling
is_a: GO:1903939 ! regulation of TORC2 signaling
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0038203 ! TORC2 signaling
relationship: negatively_regulates GO:0038203 ! TORC2 signaling
created_by: al
creation_date: 2015-02-16T18:28:50Z

[Term]
id: GO:1903941
name: negative regulation of respiratory gaseous exchange
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of respiratory gaseous exchange." [GO_REF:0000058, GOC:TermGenie, PMID:22819705]
synonym: "down regulation of respiratory gaseous exchange" EXACT [GOC:TermGenie]
synonym: "down-regulation of respiratory gaseous exchange" EXACT [GOC:TermGenie]
synonym: "downregulation of respiratory gaseous exchange" EXACT [GOC:TermGenie]
synonym: "inhibition of respiratory gaseous exchange" NARROW [GOC:TermGenie]
is_a: GO:0043576 ! regulation of respiratory gaseous exchange
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007585 ! respiratory gaseous exchange
relationship: negatively_regulates GO:0007585 ! respiratory gaseous exchange
created_by: sl
creation_date: 2015-02-17T20:26:24Z

[Term]
id: GO:1903942
name: positive regulation of respiratory gaseous exchange
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of respiratory gaseous exchange." [GO_REF:0000058, GOC:TermGenie, PMID:22819705]
synonym: "activation of respiratory gaseous exchange" NARROW [GOC:TermGenie]
synonym: "up regulation of respiratory gaseous exchange" EXACT [GOC:TermGenie]
synonym: "up-regulation of respiratory gaseous exchange" EXACT [GOC:TermGenie]
synonym: "upregulation of respiratory gaseous exchange" EXACT [GOC:TermGenie]
is_a: GO:0043576 ! regulation of respiratory gaseous exchange
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007585 ! respiratory gaseous exchange
relationship: positively_regulates GO:0007585 ! respiratory gaseous exchange
created_by: sl
creation_date: 2015-02-17T20:26:35Z

[Term]
id: GO:1903943
name: regulation of hepatocyte apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hepatocyte apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:8649852]
synonym: "regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie]
is_a: GO:1904035 ! regulation of epithelial cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097284 ! hepatocyte apoptotic process
relationship: regulates GO:0097284 ! hepatocyte apoptotic process
created_by: sl
creation_date: 2015-02-19T12:54:40Z

[Term]
id: GO:1903944
name: negative regulation of hepatocyte apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hepatocyte apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:8649852]
synonym: "down regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of hepatocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of hepatocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of hepatocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of hepatocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "inhibition of hepatocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of hepatocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie]
is_a: GO:1903943 ! regulation of hepatocyte apoptotic process
is_a: GO:1904036 ! negative regulation of epithelial cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097284 ! hepatocyte apoptotic process
relationship: negatively_regulates GO:0097284 ! hepatocyte apoptotic process
created_by: sl
creation_date: 2015-02-19T12:54:50Z

[Term]
id: GO:1903945
name: positive regulation of hepatocyte apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hepatocyte apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:8649852]
synonym: "activation of hepatocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of hepatocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of hepatocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of hepatocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of hepatocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of hepatocyte apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:1903943 ! regulation of hepatocyte apoptotic process
is_a: GO:1904037 ! positive regulation of epithelial cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097284 ! hepatocyte apoptotic process
relationship: positively_regulates GO:0097284 ! hepatocyte apoptotic process
created_by: sl
creation_date: 2015-02-19T12:54:59Z

[Term]
id: GO:1903946
name: negative regulation of ventricular cardiac muscle cell action potential
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ventricular cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747]
synonym: "down regulation of ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "down-regulation of ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "downregulation of ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "inhibition of ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie]
is_a: GO:0045759 ! negative regulation of action potential
is_a: GO:0051271 ! negative regulation of cellular component movement
is_a: GO:0055118 ! negative regulation of cardiac muscle contraction
is_a: GO:0098911 ! regulation of ventricular cardiac muscle cell action potential
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0086005 ! ventricular cardiac muscle cell action potential
relationship: negatively_regulates GO:0086005 ! ventricular cardiac muscle cell action potential
created_by: nc
creation_date: 2015-02-20T14:31:55Z

[Term]
id: GO:1903947
name: positive regulation of ventricular cardiac muscle cell action potential
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ventricular cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747]
synonym: "activation of ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "up regulation of ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up-regulation of ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "upregulation of ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
is_a: GO:0045760 ! positive regulation of action potential
is_a: GO:0060452 ! positive regulation of cardiac muscle contraction
is_a: GO:0098911 ! regulation of ventricular cardiac muscle cell action potential
is_a: GO:1903116 ! positive regulation of actin filament-based movement
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0086005 ! ventricular cardiac muscle cell action potential
relationship: positively_regulates GO:0086005 ! ventricular cardiac muscle cell action potential
created_by: nc
creation_date: 2015-02-20T14:32:04Z

[Term]
id: GO:1903948
name: negative regulation of atrial cardiac muscle cell action potential
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of atrial cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747]
synonym: "down regulation of atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "down-regulation of atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "downregulation of atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "inhibition of atrial cardiac muscle cell action potential" NARROW [GOC:TermGenie]
is_a: GO:0010648 ! negative regulation of cell communication
is_a: GO:0045759 ! negative regulation of action potential
is_a: GO:0051271 ! negative regulation of cellular component movement
is_a: GO:0055118 ! negative regulation of cardiac muscle contraction
is_a: GO:0098910 ! regulation of atrial cardiac muscle cell action potential
is_a: GO:1903780 ! negative regulation of cardiac conduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0086014 ! atrial cardiac muscle cell action potential
relationship: negatively_regulates GO:0086014 ! atrial cardiac muscle cell action potential
created_by: nc
creation_date: 2015-02-20T14:36:33Z

[Term]
id: GO:1903949
name: positive regulation of atrial cardiac muscle cell action potential
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of atrial cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747]
synonym: "activation of atrial cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "up regulation of atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up-regulation of atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "upregulation of atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie]
is_a: GO:0010647 ! positive regulation of cell communication
is_a: GO:0045760 ! positive regulation of action potential
is_a: GO:0060452 ! positive regulation of cardiac muscle contraction
is_a: GO:0098910 ! regulation of atrial cardiac muscle cell action potential
is_a: GO:1903116 ! positive regulation of actin filament-based movement
is_a: GO:1903781 ! positive regulation of cardiac conduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0086014 ! atrial cardiac muscle cell action potential
relationship: positively_regulates GO:0086014 ! atrial cardiac muscle cell action potential
created_by: nc
creation_date: 2015-02-20T14:36:42Z

[Term]
id: GO:1903950
name: negative regulation of AV node cell action potential
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of AV node cell action potential." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747]
synonym: "down regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "down regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "down regulation of AV node cell action potential" EXACT [GOC:TermGenie]
synonym: "down-regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "down-regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "down-regulation of AV node cell action potential" EXACT [GOC:TermGenie]
synonym: "downregulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "downregulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "downregulation of AV node cell action potential" EXACT [GOC:TermGenie]
synonym: "inhibition of atrioventricular node cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "inhibition of AV node cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "inhibition of AV node cell action potential" NARROW [GOC:TermGenie]
synonym: "negative regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "negative regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
is_a: GO:0010648 ! negative regulation of cell communication
is_a: GO:0045759 ! negative regulation of action potential
is_a: GO:0098904 ! regulation of AV node cell action potential
is_a: GO:1903780 ! negative regulation of cardiac conduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0086016 ! AV node cell action potential
relationship: negatively_regulates GO:0086016 ! AV node cell action potential
created_by: nc
creation_date: 2015-02-20T14:59:41Z

[Term]
id: GO:1903951
name: positive regulation of AV node cell action potential
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of AV node cell action potential." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747]
synonym: "activation of atrioventricular node cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "activation of AV node cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "activation of AV node cell action potential" NARROW [GOC:TermGenie]
synonym: "positive regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "positive regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up regulation of AV node cell action potential" EXACT [GOC:TermGenie]
synonym: "up-regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up-regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up-regulation of AV node cell action potential" EXACT [GOC:TermGenie]
synonym: "upregulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "upregulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "upregulation of AV node cell action potential" EXACT [GOC:TermGenie]
is_a: GO:0010647 ! positive regulation of cell communication
is_a: GO:0045760 ! positive regulation of action potential
is_a: GO:0098904 ! regulation of AV node cell action potential
is_a: GO:1903781 ! positive regulation of cardiac conduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0086016 ! AV node cell action potential
relationship: positively_regulates GO:0086016 ! AV node cell action potential
created_by: nc
creation_date: 2015-02-20T14:59:50Z

[Term]
id: GO:1903952
name: regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization." [GO_REF:0000059, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747]
synonym: "regulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization" EXACT [GOC:TermGenie]
is_a: GO:0098910 ! regulation of atrial cardiac muscle cell action potential
is_a: GO:1901016 ! regulation of potassium ion transmembrane transporter activity
is_a: GO:1905031 ! regulation of membrane repolarization during cardiac muscle cell action potential
is_a: GO:2001257 ! regulation of cation channel activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0086089 ! voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
relationship: regulates GO:0086089 ! voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
created_by: nc
creation_date: 2015-02-24T10:32:06Z

[Term]
id: GO:1903953
name: negative regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization." [GO_REF:0000059, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747]
synonym: "down regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization" EXACT [GOC:TermGenie]
synonym: "down regulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization" EXACT [GOC:TermGenie]
synonym: "down-regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization" EXACT [GOC:TermGenie]
synonym: "down-regulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization" EXACT [GOC:TermGenie]
synonym: "downregulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization" EXACT [GOC:TermGenie]
synonym: "downregulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization" EXACT [GOC:TermGenie]
synonym: "inhibition of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization" NARROW [GOC:TermGenie]
synonym: "inhibition of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization" NARROW [GOC:TermGenie]
synonym: "negative regulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization" EXACT [GOC:TermGenie]
is_a: GO:1903817 ! negative regulation of voltage-gated potassium channel activity
is_a: GO:1903948 ! negative regulation of atrial cardiac muscle cell action potential
is_a: GO:1903952 ! regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
is_a: GO:1905032 ! negative regulation of membrane repolarization during cardiac muscle cell action potential
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0086089 ! voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
relationship: negatively_regulates GO:0086089 ! voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
created_by: nc
creation_date: 2015-02-24T10:32:16Z

[Term]
id: GO:1903954
name: positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization." [GO_REF:0000059, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747]
synonym: "activation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization" NARROW [GOC:TermGenie]
synonym: "activation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization" NARROW [GOC:TermGenie]
synonym: "positive regulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization" EXACT [GOC:TermGenie]
synonym: "up regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization" EXACT [GOC:TermGenie]
synonym: "up regulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization" EXACT [GOC:TermGenie]
synonym: "up-regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization" EXACT [GOC:TermGenie]
synonym: "up-regulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization" EXACT [GOC:TermGenie]
synonym: "upregulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization" EXACT [GOC:TermGenie]
synonym: "upregulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization" EXACT [GOC:TermGenie]
is_a: GO:1903818 ! positive regulation of voltage-gated potassium channel activity
is_a: GO:1903949 ! positive regulation of atrial cardiac muscle cell action potential
is_a: GO:1903952 ! regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
is_a: GO:1905033 ! positive regulation of membrane repolarization during cardiac muscle cell action potential
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0086089 ! voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
relationship: positively_regulates GO:0086089 ! voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
created_by: nc
creation_date: 2015-02-24T10:32:24Z

[Term]
id: GO:1903955
name: positive regulation of protein targeting to mitochondrion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein targeting to mitochondrion." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:24270810]
comment: An example of this is PINK1 in human (UniProt symbol Q9BXM7) in PMID:24270810 inferred from mutant phenotype.
synonym: "activation of mitochondrial protein import" RELATED [GOC:TermGenie]
synonym: "activation of mitochondrial translocation" RELATED [GOC:TermGenie]
synonym: "activation of protein import into mitochondrion" NARROW [GOC:TermGenie]
synonym: "activation of protein targeting to mitochondria" NARROW [GOC:TermGenie]
synonym: "activation of protein targeting to mitochondrion" NARROW [GOC:TermGenie]
synonym: "activation of protein-mitochondrial targeting" NARROW [GOC:TermGenie]
synonym: "positive regulation of mitochondrial protein import" RELATED [GOC:TermGenie]
synonym: "positive regulation of mitochondrial translocation" RELATED [GOC:TermGenie]
synonym: "positive regulation of protein import into mitochondrion" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein targeting to mitochondria" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein-mitochondrial targeting" EXACT [GOC:TermGenie]
synonym: "up regulation of mitochondrial protein import" RELATED [GOC:TermGenie]
synonym: "up regulation of mitochondrial translocation" RELATED [GOC:TermGenie]
synonym: "up regulation of protein import into mitochondrion" EXACT [GOC:TermGenie]
synonym: "up regulation of protein targeting to mitochondria" EXACT [GOC:TermGenie]
synonym: "up regulation of protein targeting to mitochondrion" EXACT [GOC:TermGenie]
synonym: "up regulation of protein-mitochondrial targeting" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitochondrial protein import" RELATED [GOC:TermGenie]
synonym: "up-regulation of mitochondrial translocation" RELATED [GOC:TermGenie]
synonym: "up-regulation of protein import into mitochondrion" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein targeting to mitochondria" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein targeting to mitochondrion" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein-mitochondrial targeting" EXACT [GOC:TermGenie]
synonym: "upregulation of mitochondrial protein import" RELATED [GOC:TermGenie]
synonym: "upregulation of mitochondrial translocation" RELATED [GOC:TermGenie]
synonym: "upregulation of protein import into mitochondrion" EXACT [GOC:TermGenie]
synonym: "upregulation of protein targeting to mitochondria" EXACT [GOC:TermGenie]
synonym: "upregulation of protein targeting to mitochondrion" EXACT [GOC:TermGenie]
synonym: "upregulation of protein-mitochondrial targeting" EXACT [GOC:TermGenie]
is_a: GO:0010822 ! positive regulation of mitochondrion organization
is_a: GO:0090316 ! positive regulation of intracellular protein transport
is_a: GO:1903214 ! regulation of protein targeting to mitochondrion
is_a: GO:1903651 ! positive regulation of cytoplasmic transport
is_a: GO:1903749 ! positive regulation of establishment of protein localization to mitochondrion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006626 ! protein targeting to mitochondrion
relationship: positively_regulates GO:0006626 ! protein targeting to mitochondrion
created_by: pad
creation_date: 2015-02-24T16:58:21Z

[Term]
id: GO:1903956
name: response to latrunculin B
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a latrunculin B stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18951025]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0097305 ! response to alcohol
created_by: al
creation_date: 2015-02-24T17:00:11Z

[Term]
id: GO:1903957
name: cellular response to latrunculin B
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a latrunculin B stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18951025]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:0097306 ! cellular response to alcohol
is_a: GO:1903956 ! response to latrunculin B
created_by: al
creation_date: 2015-02-24T17:00:21Z

[Term]
id: GO:1903958
name: nitric-oxide synthase complex
namespace: cellular_component
def: "A protein complex which is capable of nitric-oxide synthase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:25417112]
comment: An example of this is NOS2 in human (P35228) in PMID:25417112 (inferred from direct assay).
synonym: "iNOS-S100A8/A9 complex" NARROW []
is_a: GO:1990204 ! oxidoreductase complex
created_by: bhm
creation_date: 2015-02-25T10:45:01Z

[Term]
id: GO:1903959
name: regulation of anion transmembrane transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of anion transmembrane transport." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
is_a: GO:0034765 ! regulation of ion transmembrane transport
is_a: GO:0044070 ! regulation of anion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0098656 ! anion transmembrane transport
relationship: regulates GO:0098656 ! anion transmembrane transport
created_by: pr
creation_date: 2015-02-25T13:52:25Z

[Term]
id: GO:1903960
name: negative regulation of anion transmembrane transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of anion transmembrane transport." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "down regulation of anion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of anion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "downregulation of anion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "inhibition of anion transmembrane transport" NARROW [GOC:TermGenie]
is_a: GO:0034766 ! negative regulation of ion transmembrane transport
is_a: GO:1903792 ! negative regulation of anion transport
is_a: GO:1903959 ! regulation of anion transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0098656 ! anion transmembrane transport
relationship: negatively_regulates GO:0098656 ! anion transmembrane transport
created_by: pr
creation_date: 2015-02-25T13:52:35Z

[Term]
id: GO:1903961
name: positive regulation of anion transmembrane transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of anion transmembrane transport." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "activation of anion transmembrane transport" NARROW [GOC:TermGenie]
synonym: "up regulation of anion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of anion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "upregulation of anion transmembrane transport" EXACT [GOC:TermGenie]
is_a: GO:0034767 ! positive regulation of ion transmembrane transport
is_a: GO:1903793 ! positive regulation of anion transport
is_a: GO:1903959 ! regulation of anion transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0098656 ! anion transmembrane transport
relationship: positively_regulates GO:0098656 ! anion transmembrane transport
created_by: pr
creation_date: 2015-02-25T13:52:44Z

[Term]
id: GO:1903962
name: arachidonate transporter activity
namespace: molecular_function
def: "Enables the directed movement of arachidonate into, out of or within a cell, or between cells." [GO_REF:0000066, GOC:bhm, GOC:TermGenie, PMID:15642721]
comment: An example of this is S100A9 in human (P06702) in PMID:15642721 (inferred from direct assay).
synonym: "arachidonic acid transporter activity" EXACT []
is_a: GO:0005324 ! long-chain fatty acid transporter activity
relationship: part_of GO:1903963 ! arachidonate transport
created_by: bhm
creation_date: 2015-02-25T15:51:12Z

[Term]
id: GO:1903963
name: arachidonate transport
namespace: biological_process
def: "The directed movement of an arachidonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GO_REF:0000065, GOC:bhm, GOC:TermGenie, PMID:15642721]
synonym: "arachidonic acid transport" EXACT []
is_a: GO:0015909 ! long-chain fatty acid transport
is_a: GO:0071715 ! icosanoid transport
created_by: bhm
creation_date: 2015-02-25T16:06:14Z

[Term]
id: GO:1903964
name: monounsaturated fatty acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving monounsaturated fatty acid." [GO_REF:0000068, GOC:hjd, GOC:TermGenie, PMID:16443825]
comment: For example, stearoyl-coenzyme A desaturase (Scd) catalyzes the desaturation of saturated fatty acids to monounsaturated fatty acids in mammals and yeast.
synonym: "monounsaturated fatty acid metabolism" EXACT [GOC:TermGenie]
is_a: GO:0033559 ! unsaturated fatty acid metabolic process
created_by: pr
creation_date: 2015-02-25T20:35:48Z

[Term]
id: GO:1903965
name: monounsaturated fatty acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of monounsaturated fatty acid." [GO_REF:0000068, GOC:hjd, GOC:TermGenie, PMID:16443825]
synonym: "monounsaturated fatty acid breakdown" EXACT [GOC:TermGenie]
synonym: "monounsaturated fatty acid catabolism" EXACT [GOC:TermGenie]
synonym: "monounsaturated fatty acid degradation" EXACT [GOC:TermGenie]
is_a: GO:0009062 ! fatty acid catabolic process
is_a: GO:1903964 ! monounsaturated fatty acid metabolic process
created_by: pr
creation_date: 2015-02-25T20:35:58Z

[Term]
id: GO:1903966
name: monounsaturated fatty acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of monounsaturated fatty acid." [GO_REF:0000068, GOC:hjd, GOC:TermGenie, PMID:16443825]
comment: For example, stearoyl-coenzyme A desaturase (Scd) catalyzes the desaturation of saturated fatty acids to monounsaturated fatty acids in mammals and yeast.
synonym: "monounsaturated fatty acid anabolism" EXACT [GOC:TermGenie]
synonym: "monounsaturated fatty acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "monounsaturated fatty acid formation" EXACT [GOC:TermGenie]
synonym: "monounsaturated fatty acid synthesis" EXACT [GOC:TermGenie]
is_a: GO:0006636 ! unsaturated fatty acid biosynthetic process
is_a: GO:1903964 ! monounsaturated fatty acid metabolic process
created_by: pr
creation_date: 2015-02-25T20:36:07Z

[Term]
id: GO:1903967
name: response to micafungin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a micafungin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16928959]
is_a: GO:0033993 ! response to lipid
is_a: GO:1901652 ! response to peptide
created_by: al
creation_date: 2015-02-27T09:57:38Z

[Term]
id: GO:1903968
name: cellular response to micafungin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a micafungin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16928959]
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:1901653 ! cellular response to peptide
is_a: GO:1903967 ! response to micafungin
created_by: al
creation_date: 2015-02-27T09:57:44Z

[Term]
id: GO:1903969
name: regulation of response to macrophage colony-stimulating factor
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to macrophage colony-stimulating factor." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
synonym: "regulation of response to M-CSF" EXACT [GOC:TermGenie]
synonym: "regulation of response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie]
synonym: "regulation of response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie]
is_a: GO:0060759 ! regulation of response to cytokine stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0036005 ! response to macrophage colony-stimulating factor
relationship: regulates GO:0036005 ! response to macrophage colony-stimulating factor
created_by: nc
creation_date: 2015-03-02T14:41:02Z

[Term]
id: GO:1903970
name: negative regulation of response to macrophage colony-stimulating factor
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to macrophage colony-stimulating factor." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
synonym: "down regulation of response to M-CSF" EXACT [GOC:TermGenie]
synonym: "down regulation of response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie]
synonym: "down regulation of response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to M-CSF" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie]
synonym: "downregulation of response to M-CSF" EXACT [GOC:TermGenie]
synonym: "downregulation of response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie]
synonym: "downregulation of response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie]
synonym: "inhibition of response to M-CSF" NARROW [GOC:TermGenie]
synonym: "inhibition of response to macrophage colony-stimulating factor" NARROW [GOC:TermGenie]
synonym: "inhibition of response to macrophage colony-stimulating factor stimulus" NARROW [GOC:TermGenie]
synonym: "negative regulation of response to M-CSF" EXACT [GOC:TermGenie]
synonym: "negative regulation of response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie]
synonym: "negative regulation of response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie]
is_a: GO:0060761 ! negative regulation of response to cytokine stimulus
is_a: GO:1903969 ! regulation of response to macrophage colony-stimulating factor
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0036005 ! response to macrophage colony-stimulating factor
relationship: negatively_regulates GO:0036005 ! response to macrophage colony-stimulating factor
created_by: nc
creation_date: 2015-03-02T14:41:08Z

[Term]
id: GO:1903971
name: positive regulation of response to macrophage colony-stimulating factor
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to macrophage colony-stimulating factor." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
synonym: "activation of response to M-CSF" NARROW [GOC:TermGenie]
synonym: "activation of response to macrophage colony-stimulating factor" NARROW [GOC:TermGenie]
synonym: "activation of response to macrophage colony-stimulating factor stimulus" NARROW [GOC:TermGenie]
synonym: "positive regulation of response to M-CSF" EXACT [GOC:TermGenie]
synonym: "positive regulation of response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie]
synonym: "positive regulation of response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie]
synonym: "up regulation of response to M-CSF" EXACT [GOC:TermGenie]
synonym: "up regulation of response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie]
synonym: "up regulation of response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to M-CSF" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie]
synonym: "upregulation of response to M-CSF" EXACT [GOC:TermGenie]
synonym: "upregulation of response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie]
synonym: "upregulation of response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie]
is_a: GO:0060760 ! positive regulation of response to cytokine stimulus
is_a: GO:1903969 ! regulation of response to macrophage colony-stimulating factor
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0036005 ! response to macrophage colony-stimulating factor
relationship: positively_regulates GO:0036005 ! response to macrophage colony-stimulating factor
created_by: nc
creation_date: 2015-03-02T14:41:14Z

[Term]
id: GO:1903972
name: regulation of cellular response to macrophage colony-stimulating factor stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular response to macrophage colony-stimulating factor stimulus." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
synonym: "regulation of cellular response to M-CSF stimulus" EXACT [GOC:TermGenie]
synonym: "regulation of cellular response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie]
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:1903969 ! regulation of response to macrophage colony-stimulating factor
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0036006 ! cellular response to macrophage colony-stimulating factor stimulus
relationship: regulates GO:0036006 ! cellular response to macrophage colony-stimulating factor stimulus
created_by: nc
creation_date: 2015-03-02T14:50:14Z

[Term]
id: GO:1903973
name: negative regulation of cellular response to macrophage colony-stimulating factor stimulus
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to macrophage colony-stimulating factor stimulus." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
synonym: "down regulation of cellular response to M-CSF stimulus" EXACT [GOC:TermGenie]
synonym: "down regulation of cellular response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie]
synonym: "down regulation of cellular response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular response to M-CSF stimulus" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular response to M-CSF stimulus" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie]
synonym: "inhibition of cellular response to M-CSF stimulus" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular response to macrophage colony-stimulating factor" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular response to macrophage colony-stimulating factor stimulus" NARROW [GOC:TermGenie]
synonym: "negative regulation of cellular response to M-CSF stimulus" EXACT [GOC:TermGenie]
synonym: "negative regulation of cellular response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:1903970 ! negative regulation of response to macrophage colony-stimulating factor
is_a: GO:1903972 ! regulation of cellular response to macrophage colony-stimulating factor stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0036006 ! cellular response to macrophage colony-stimulating factor stimulus
relationship: negatively_regulates GO:0036006 ! cellular response to macrophage colony-stimulating factor stimulus
created_by: nc
creation_date: 2015-03-02T14:50:20Z

[Term]
id: GO:1903974
name: positive regulation of cellular response to macrophage colony-stimulating factor stimulus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellular response to macrophage colony-stimulating factor stimulus." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
synonym: "activation of cellular response to M-CSF stimulus" NARROW [GOC:TermGenie]
synonym: "activation of cellular response to macrophage colony-stimulating factor" NARROW [GOC:TermGenie]
synonym: "activation of cellular response to macrophage colony-stimulating factor stimulus" NARROW [GOC:TermGenie]
synonym: "positive regulation of cellular response to M-CSF stimulus" EXACT [GOC:TermGenie]
synonym: "positive regulation of cellular response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular response to M-CSF stimulus" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular response to M-CSF stimulus" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular response to M-CSF stimulus" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:1903971 ! positive regulation of response to macrophage colony-stimulating factor
is_a: GO:1903972 ! regulation of cellular response to macrophage colony-stimulating factor stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0036006 ! cellular response to macrophage colony-stimulating factor stimulus
relationship: positively_regulates GO:0036006 ! cellular response to macrophage colony-stimulating factor stimulus
created_by: nc
creation_date: 2015-03-02T14:50:25Z

[Term]
id: GO:1903975
name: regulation of glial cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glial cell migration." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
synonym: "regulation of glia cell migration" EXACT [GOC:TermGenie]
is_a: GO:0014013 ! regulation of gliogenesis
is_a: GO:0030334 ! regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008347 ! glial cell migration
relationship: regulates GO:0008347 ! glial cell migration
created_by: nc
creation_date: 2015-03-02T15:13:31Z

[Term]
id: GO:1903976
name: negative regulation of glial cell migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glial cell migration." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
synonym: "down regulation of glia cell migration" EXACT [GOC:TermGenie]
synonym: "down regulation of glial cell migration" EXACT [GOC:TermGenie]
synonym: "down-regulation of glia cell migration" EXACT [GOC:TermGenie]
synonym: "down-regulation of glial cell migration" EXACT [GOC:TermGenie]
synonym: "downregulation of glia cell migration" EXACT [GOC:TermGenie]
synonym: "downregulation of glial cell migration" EXACT [GOC:TermGenie]
synonym: "inhibition of glia cell migration" NARROW [GOC:TermGenie]
synonym: "inhibition of glial cell migration" NARROW [GOC:TermGenie]
synonym: "negative regulation of glia cell migration" EXACT [GOC:TermGenie]
is_a: GO:0014014 ! negative regulation of gliogenesis
is_a: GO:0030336 ! negative regulation of cell migration
is_a: GO:1903975 ! regulation of glial cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008347 ! glial cell migration
relationship: negatively_regulates GO:0008347 ! glial cell migration
created_by: nc
creation_date: 2015-03-02T15:13:38Z

[Term]
id: GO:1903977
name: positive regulation of glial cell migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glial cell migration." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
synonym: "activation of glia cell migration" NARROW [GOC:TermGenie]
synonym: "activation of glial cell migration" NARROW [GOC:TermGenie]
synonym: "positive regulation of glia cell migration" EXACT [GOC:TermGenie]
synonym: "up regulation of glia cell migration" EXACT [GOC:TermGenie]
synonym: "up regulation of glial cell migration" EXACT [GOC:TermGenie]
synonym: "up-regulation of glia cell migration" EXACT [GOC:TermGenie]
synonym: "up-regulation of glial cell migration" EXACT [GOC:TermGenie]
synonym: "upregulation of glia cell migration" EXACT [GOC:TermGenie]
synonym: "upregulation of glial cell migration" EXACT [GOC:TermGenie]
is_a: GO:0014015 ! positive regulation of gliogenesis
is_a: GO:0030335 ! positive regulation of cell migration
is_a: GO:1903975 ! regulation of glial cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008347 ! glial cell migration
relationship: positively_regulates GO:0008347 ! glial cell migration
created_by: nc
creation_date: 2015-03-02T15:13:43Z

[Term]
id: GO:1903978
name: regulation of microglial cell activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of microglial cell activation." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
is_a: GO:0043030 ! regulation of macrophage activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001774 ! microglial cell activation
relationship: regulates GO:0001774 ! microglial cell activation
created_by: nc
creation_date: 2015-03-02T15:17:33Z

[Term]
id: GO:1903979
name: negative regulation of microglial cell activation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of microglial cell activation." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
synonym: "down regulation of microglial cell activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of microglial cell activation" EXACT [GOC:TermGenie]
synonym: "downregulation of microglial cell activation" EXACT [GOC:TermGenie]
synonym: "inhibition of microglial cell activation" NARROW [GOC:TermGenie]
is_a: GO:0043031 ! negative regulation of macrophage activation
is_a: GO:1903978 ! regulation of microglial cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001774 ! microglial cell activation
relationship: negatively_regulates GO:0001774 ! microglial cell activation
created_by: nc
creation_date: 2015-03-02T15:17:39Z

[Term]
id: GO:1903980
name: positive regulation of microglial cell activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of microglial cell activation." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
synonym: "activation of microglial cell activation" NARROW [GOC:TermGenie]
synonym: "up regulation of microglial cell activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of microglial cell activation" EXACT [GOC:TermGenie]
synonym: "upregulation of microglial cell activation" EXACT [GOC:TermGenie]
is_a: GO:0043032 ! positive regulation of macrophage activation
is_a: GO:1903978 ! regulation of microglial cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001774 ! microglial cell activation
relationship: positively_regulates GO:0001774 ! microglial cell activation
created_by: nc
creation_date: 2015-03-02T15:17:44Z

[Term]
id: GO:1903981
name: enterobactin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with enterobactin." [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:21951132]
synonym: "Enterochelin" EXACT []
synonym: "siderophore" NARROW []
is_a: GO:0043168 ! anion binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding
created_by: mr
creation_date: 2015-03-02T17:21:54Z

[Term]
id: GO:1903982
name: negative regulation of microvillus length
namespace: biological_process
def: "A process that decreases the length of a microvillus." [GOC:als, PMID:22114352]
synonym: "down regulation of regulation of microvillus length" EXACT [GOC:TermGenie]
synonym: "down-regulation of regulation of microvillus length" EXACT [GOC:TermGenie]
synonym: "downregulation of regulation of microvillus length" EXACT [GOC:TermGenie]
synonym: "inhibition of regulation of microvillus length" NARROW [GOC:TermGenie]
is_a: GO:0031345 ! negative regulation of cell projection organization
is_a: GO:0032532 ! regulation of microvillus length
created_by: als
creation_date: 2015-03-03T13:23:52Z

[Term]
id: GO:1903983
name: positive regulation of microvillus length
namespace: biological_process
def: "A process that increases the length of a microvillus." [GOC:als, PMID:22114352]
synonym: "activation of regulation of microvillus length" NARROW [GOC:TermGenie]
synonym: "up regulation of regulation of microvillus length" EXACT [GOC:TermGenie]
synonym: "up-regulation of regulation of microvillus length" EXACT [GOC:TermGenie]
synonym: "upregulation of regulation of microvillus length" EXACT [GOC:TermGenie]
is_a: GO:0031346 ! positive regulation of cell projection organization
is_a: GO:0032532 ! regulation of microvillus length
created_by: als
creation_date: 2015-03-03T13:23:58Z

[Term]
id: GO:1903984
name: positive regulation of TRAIL-activated apoptotic signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of TRAIL-activated apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24939851]
synonym: "activation of TRAIL-activated apoptotic signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of TRAIL-activated extrinsic apoptotic signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of TRAIL-induced apoptotic signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of TRAIL-activated extrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of TRAIL-induced apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of TRAIL-activated apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of TRAIL-activated extrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of TRAIL-induced apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of TRAIL-activated apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of TRAIL-activated extrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of TRAIL-induced apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of TRAIL-activated apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of TRAIL-activated extrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of TRAIL-induced apoptotic signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:1902043 ! positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
is_a: GO:1903121 ! regulation of TRAIL-activated apoptotic signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0036462 ! TRAIL-activated apoptotic signaling pathway
relationship: positively_regulates GO:0036462 ! TRAIL-activated apoptotic signaling pathway
created_by: bf
creation_date: 2015-03-03T15:04:21Z

[Term]
id: GO:1903985
name: regulation of intestinal D-glucose absorption
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of intestinal D-glucose absorption." [GO_REF:0000058, GOA:als, GOC:TermGenie, PMID:22114352]
is_a: GO:0010827 ! regulation of glucose transport
is_a: GO:1904478 ! regulation of intestinal absorption
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001951 ! intestinal D-glucose absorption
relationship: regulates GO:0001951 ! intestinal D-glucose absorption
created_by: als
creation_date: 2015-03-04T10:07:55Z

[Term]
id: GO:1903988
name: ferrous iron export
namespace: biological_process
def: "The directed movement of iron(2+) out of a cell or organelle." [GO_REF:0000074, GOC:BHF, GOC:kom, GOC:rl, GOC:TermGenie, PMID:15514116]
comment: ferroportin, Slc40a1, Q9JHI9
synonym: "iron(2+) export" EXACT []
is_a: GO:0070839 ! divalent metal ion export
is_a: GO:1903414 ! iron cation export
is_a: GO:1903874 ! ferrous iron transmembrane transport
created_by: rl
creation_date: 2015-03-04T11:45:01Z

[Term]
id: GO:1903989
name: regulation of ferrous iron import into cell
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ferrous iron import into cell." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23256035]
synonym: "regulation of ferrous ion import into cell" EXACT [GOC:TermGenie]
is_a: GO:1900390 ! regulation of iron ion import
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097460 ! ferrous iron import into cell
relationship: regulates GO:0097460 ! ferrous iron import into cell
created_by: rl
creation_date: 2015-03-04T14:37:36Z

[Term]
id: GO:1903990
name: negative regulation of ferrous iron import into cell
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ferrous iron import into cell." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23256035]
synonym: "down regulation of ferrous ion import into cell" EXACT [GOC:TermGenie]
synonym: "down regulation of ferrous iron import into cell" EXACT [GOC:TermGenie]
synonym: "down-regulation of ferrous ion import into cell" EXACT [GOC:TermGenie]
synonym: "down-regulation of ferrous iron import into cell" EXACT [GOC:TermGenie]
synonym: "downregulation of ferrous ion import into cell" EXACT [GOC:TermGenie]
synonym: "downregulation of ferrous iron import into cell" EXACT [GOC:TermGenie]
synonym: "inhibition of ferrous ion import into cell" NARROW [GOC:TermGenie]
synonym: "inhibition of ferrous iron import into cell" NARROW [GOC:TermGenie]
synonym: "negative regulation of ferrous ion import into cell" EXACT [GOC:TermGenie]
is_a: GO:0034757 ! negative regulation of iron ion transport
is_a: GO:1903989 ! regulation of ferrous iron import into cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097460 ! ferrous iron import into cell
relationship: negatively_regulates GO:0097460 ! ferrous iron import into cell
created_by: rl
creation_date: 2015-03-04T14:37:42Z

[Term]
id: GO:1903991
name: positive regulation of ferrous iron import into cell
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ferrous iron import into cell." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23256035]
synonym: "activation of ferrous ion import into cell" NARROW [GOC:TermGenie]
synonym: "activation of ferrous iron import into cell" NARROW [GOC:TermGenie]
synonym: "positive regulation of ferrous ion import into cell" EXACT [GOC:TermGenie]
synonym: "up regulation of ferrous ion import into cell" EXACT [GOC:TermGenie]
synonym: "up regulation of ferrous iron import into cell" EXACT [GOC:TermGenie]
synonym: "up-regulation of ferrous ion import into cell" EXACT [GOC:TermGenie]
synonym: "up-regulation of ferrous iron import into cell" EXACT [GOC:TermGenie]
synonym: "upregulation of ferrous ion import into cell" EXACT [GOC:TermGenie]
synonym: "upregulation of ferrous iron import into cell" EXACT [GOC:TermGenie]
is_a: GO:0034758 ! positive regulation of iron ion transport
is_a: GO:1903989 ! regulation of ferrous iron import into cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097460 ! ferrous iron import into cell
relationship: positively_regulates GO:0097460 ! ferrous iron import into cell
created_by: rl
creation_date: 2015-03-04T14:37:48Z

[Term]
id: GO:1903992
name: obsolete regulation of protein stabilization
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of protein stabilization." [GO_REF:0000058, GOC:TermGenie, PMID:18573880]
comment: This term was made obsolete because it was created in error.
synonym: "regulation of lysosomal protein stabilization" NARROW [GOC:TermGenie]
synonym: "regulation of positive regulation of protein stability" EXACT [GOC:TermGenie]
synonym: "regulation of protein sequestering" RELATED [GOC:TermGenie]
synonym: "regulation of protein stabilization" EXACT []
synonym: "regulation of protein stabilization activity" RELATED [GOC:TermGenie]
is_obsolete: true
consider: GO:0031647
created_by: pga
creation_date: 2015-03-05T13:32:49Z

[Term]
id: GO:1903993
name: obsolete negative regulation of protein stabilization
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of protein stabilization." [GO_REF:0000058, GOC:TermGenie, PMID:18573880]
comment: This term was made obsolete because it was created in error.
synonym: "down regulation of lysosomal protein stabilization" NARROW [GOC:TermGenie]
synonym: "down regulation of positive regulation of protein stability" EXACT [GOC:TermGenie]
synonym: "down regulation of protein sequestering" RELATED [GOC:TermGenie]
synonym: "down regulation of protein stabilization" EXACT [GOC:TermGenie]
synonym: "down regulation of protein stabilization activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of lysosomal protein stabilization" NARROW [GOC:TermGenie]
synonym: "down-regulation of positive regulation of protein stability" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein sequestering" RELATED [GOC:TermGenie]
synonym: "down-regulation of protein stabilization" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein stabilization activity" RELATED [GOC:TermGenie]
synonym: "downregulation of lysosomal protein stabilization" NARROW [GOC:TermGenie]
synonym: "downregulation of positive regulation of protein stability" EXACT [GOC:TermGenie]
synonym: "downregulation of protein sequestering" RELATED [GOC:TermGenie]
synonym: "downregulation of protein stabilization" EXACT [GOC:TermGenie]
synonym: "downregulation of protein stabilization activity" RELATED [GOC:TermGenie]
synonym: "inhibition of lysosomal protein stabilization" NARROW [GOC:TermGenie]
synonym: "inhibition of positive regulation of protein stability" NARROW [GOC:TermGenie]
synonym: "inhibition of protein sequestering" RELATED [GOC:TermGenie]
synonym: "inhibition of protein stabilization" NARROW [GOC:TermGenie]
synonym: "inhibition of protein stabilization activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of lysosomal protein stabilization" NARROW [GOC:TermGenie]
synonym: "negative regulation of positive regulation of protein stability" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein sequestering" RELATED [GOC:TermGenie]
synonym: "negative regulation of protein stabilization" EXACT []
synonym: "negative regulation of protein stabilization activity" RELATED [GOC:TermGenie]
is_obsolete: true
consider: GO:0031648
created_by: pga
creation_date: 2015-03-05T13:32:55Z

[Term]
id: GO:1903994
name: obsolete positive regulation of protein stabilization
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of protein stabilization." [GO_REF:0000058, GOC:TermGenie, PMID:18573880]
comment: This term was made obsolete because it was created in error.
synonym: "activation of lysosomal protein stabilization" NARROW [GOC:TermGenie]
synonym: "activation of positive regulation of protein stability" NARROW [GOC:TermGenie]
synonym: "activation of protein sequestering" RELATED [GOC:TermGenie]
synonym: "activation of protein stabilization" NARROW [GOC:TermGenie]
synonym: "activation of protein stabilization activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of lysosomal protein stabilization" NARROW [GOC:TermGenie]
synonym: "positive regulation of positive regulation of protein stability" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein sequestering" RELATED [GOC:TermGenie]
synonym: "positive regulation of protein stabilization" EXACT []
synonym: "positive regulation of protein stabilization activity" RELATED [GOC:TermGenie]
synonym: "up regulation of lysosomal protein stabilization" NARROW [GOC:TermGenie]
synonym: "up regulation of positive regulation of protein stability" EXACT [GOC:TermGenie]
synonym: "up regulation of protein sequestering" RELATED [GOC:TermGenie]
synonym: "up regulation of protein stabilization" EXACT [GOC:TermGenie]
synonym: "up regulation of protein stabilization activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of lysosomal protein stabilization" NARROW [GOC:TermGenie]
synonym: "up-regulation of positive regulation of protein stability" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein sequestering" RELATED [GOC:TermGenie]
synonym: "up-regulation of protein stabilization" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein stabilization activity" RELATED [GOC:TermGenie]
synonym: "upregulation of lysosomal protein stabilization" NARROW [GOC:TermGenie]
synonym: "upregulation of positive regulation of protein stability" EXACT [GOC:TermGenie]
synonym: "upregulation of protein sequestering" RELATED [GOC:TermGenie]
synonym: "upregulation of protein stabilization" EXACT [GOC:TermGenie]
synonym: "upregulation of protein stabilization activity" RELATED [GOC:TermGenie]
is_obsolete: true
consider: GO:0050821
created_by: pga
creation_date: 2015-03-05T13:33:00Z

[Term]
id: GO:1903995
name: regulation of non-membrane spanning protein tyrosine kinase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of non-membrane spanning protein tyrosine kinase activity." [GO_REF:0000059, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:10518561]
synonym: "regulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" EXACT [GOC:TermGenie]
synonym: "regulation of ATP:protein-tyrosine O-phosphotransferase activity" BROAD [GOC:TermGenie]
synonym: "regulation of Bruton's tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "regulation of cytoplasmic protein tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "regulation of focal adhesion kinase activity" NARROW [GOC:TermGenie]
synonym: "regulation of janus kinase 1 activity" NARROW [GOC:TermGenie]
synonym: "regulation of janus kinase 2 activity" NARROW [GOC:TermGenie]
synonym: "regulation of janus kinase 3 activity" NARROW [GOC:TermGenie]
synonym: "regulation of non-specific protein-tyrosine kinase activity" EXACT [GOC:TermGenie]
synonym: "regulation of p60c-src protein tyrosine kinase activity" NARROW [GOC:TermGenie]
is_a: GO:0061097 ! regulation of protein tyrosine kinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004715 ! non-membrane spanning protein tyrosine kinase activity
relationship: regulates GO:0004715 ! non-membrane spanning protein tyrosine kinase activity
created_by: nc
creation_date: 2015-03-05T16:34:35Z

[Term]
id: GO:1903996
name: negative regulation of non-membrane spanning protein tyrosine kinase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of non-membrane spanning protein tyrosine kinase activity." [GO_REF:0000059, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:10518561]
synonym: "down regulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" EXACT [GOC:TermGenie]
synonym: "down regulation of Bruton's tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of cytoplasmic protein tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of focal adhesion kinase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of janus kinase 1 activity" NARROW [GOC:TermGenie]
synonym: "down regulation of janus kinase 2 activity" NARROW [GOC:TermGenie]
synonym: "down regulation of janus kinase 3 activity" NARROW [GOC:TermGenie]
synonym: "down regulation of non-membrane spanning protein tyrosine kinase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of non-specific protein-tyrosine kinase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of p60c-src protein tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of Bruton's tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of cytoplasmic protein tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of focal adhesion kinase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of janus kinase 1 activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of janus kinase 2 activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of janus kinase 3 activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of non-membrane spanning protein tyrosine kinase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of non-specific protein-tyrosine kinase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of p60c-src protein tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" EXACT [GOC:TermGenie]
synonym: "downregulation of Bruton's tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of cytoplasmic protein tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of focal adhesion kinase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of janus kinase 1 activity" NARROW [GOC:TermGenie]
synonym: "downregulation of janus kinase 2 activity" NARROW [GOC:TermGenie]
synonym: "downregulation of janus kinase 3 activity" NARROW [GOC:TermGenie]
synonym: "downregulation of non-membrane spanning protein tyrosine kinase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of non-specific protein-tyrosine kinase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of p60c-src protein tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" NARROW [GOC:TermGenie]
synonym: "inhibition of Bruton's tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of cytoplasmic protein tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of focal adhesion kinase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of janus kinase 1 activity" NARROW [GOC:TermGenie]
synonym: "inhibition of janus kinase 2 activity" NARROW [GOC:TermGenie]
synonym: "inhibition of janus kinase 3 activity" NARROW [GOC:TermGenie]
synonym: "inhibition of non-membrane spanning protein tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of non-specific protein-tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of p60c-src protein tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of Bruton's tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of cytoplasmic protein tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of focal adhesion kinase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of janus kinase 1 activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of janus kinase 2 activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of janus kinase 3 activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of non-specific protein-tyrosine kinase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of p60c-src protein tyrosine kinase activity" NARROW [GOC:TermGenie]
is_a: GO:0061099 ! negative regulation of protein tyrosine kinase activity
is_a: GO:1903995 ! regulation of non-membrane spanning protein tyrosine kinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004715 ! non-membrane spanning protein tyrosine kinase activity
relationship: negatively_regulates GO:0004715 ! non-membrane spanning protein tyrosine kinase activity
created_by: nc
creation_date: 2015-03-05T16:34:41Z

[Term]
id: GO:1903997
name: positive regulation of non-membrane spanning protein tyrosine kinase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of non-membrane spanning protein tyrosine kinase activity." [GO_REF:0000059, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:10518561]
synonym: "activation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" NARROW [GOC:TermGenie]
synonym: "activation of Bruton's tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "activation of cytoplasmic protein tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "activation of focal adhesion kinase activity" NARROW [GOC:TermGenie]
synonym: "activation of janus kinase 1 activity" NARROW [GOC:TermGenie]
synonym: "activation of janus kinase 2 activity" NARROW [GOC:TermGenie]
synonym: "activation of janus kinase 3 activity" NARROW [GOC:TermGenie]
synonym: "activation of non-membrane spanning protein tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "activation of non-specific protein-tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "activation of p60c-src protein tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of Bruton's tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of cytoplasmic protein tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of focal adhesion kinase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of janus kinase 1 activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of janus kinase 2 activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of janus kinase 3 activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of non-specific protein-tyrosine kinase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of p60c-src protein tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" EXACT [GOC:TermGenie]
synonym: "up regulation of Bruton's tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of cytoplasmic protein tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of focal adhesion kinase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of janus kinase 1 activity" NARROW [GOC:TermGenie]
synonym: "up regulation of janus kinase 2 activity" NARROW [GOC:TermGenie]
synonym: "up regulation of janus kinase 3 activity" NARROW [GOC:TermGenie]
synonym: "up regulation of non-membrane spanning protein tyrosine kinase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of non-specific protein-tyrosine kinase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of p60c-src protein tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of Bruton's tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of cytoplasmic protein tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of focal adhesion kinase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of janus kinase 1 activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of janus kinase 2 activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of janus kinase 3 activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of non-membrane spanning protein tyrosine kinase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of non-specific protein-tyrosine kinase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of p60c-src protein tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" EXACT [GOC:TermGenie]
synonym: "upregulation of Bruton's tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of cytoplasmic protein tyrosine kinase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of focal adhesion kinase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of janus kinase 1 activity" NARROW [GOC:TermGenie]
synonym: "upregulation of janus kinase 2 activity" NARROW [GOC:TermGenie]
synonym: "upregulation of janus kinase 3 activity" NARROW [GOC:TermGenie]
synonym: "upregulation of non-membrane spanning protein tyrosine kinase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of non-specific protein-tyrosine kinase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of p60c-src protein tyrosine kinase activity" NARROW [GOC:TermGenie]
is_a: GO:0061098 ! positive regulation of protein tyrosine kinase activity
is_a: GO:1903995 ! regulation of non-membrane spanning protein tyrosine kinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004715 ! non-membrane spanning protein tyrosine kinase activity
relationship: positively_regulates GO:0004715 ! non-membrane spanning protein tyrosine kinase activity
created_by: nc
creation_date: 2015-03-05T16:34:46Z

[Term]
id: GO:1903998
name: regulation of eating behavior
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of eating behavior." [GO_REF:0000058, GOC:TermGenie, PMID:11961051]
synonym: "regulation of eating behaviour" EXACT [GOC:TermGenie]
is_a: GO:0060259 ! regulation of feeding behavior
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042755 ! eating behavior
relationship: regulates GO:0042755 ! eating behavior
created_by: sl
creation_date: 2015-03-05T20:40:22Z

[Term]
id: GO:1903999
name: negative regulation of eating behavior
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of eating behavior." [GO_REF:0000058, GOC:TermGenie, PMID:11961051]
synonym: "down regulation of eating behavior" EXACT [GOC:TermGenie]
synonym: "down regulation of eating behaviour" EXACT [GOC:TermGenie]
synonym: "down-regulation of eating behavior" EXACT [GOC:TermGenie]
synonym: "down-regulation of eating behaviour" EXACT [GOC:TermGenie]
synonym: "downregulation of eating behavior" EXACT [GOC:TermGenie]
synonym: "downregulation of eating behaviour" EXACT [GOC:TermGenie]
synonym: "inhibition of eating behavior" NARROW [GOC:TermGenie]
synonym: "inhibition of eating behaviour" NARROW [GOC:TermGenie]
synonym: "negative regulation of eating behaviour" EXACT [GOC:TermGenie]
is_a: GO:1903998 ! regulation of eating behavior
is_a: GO:2000252 ! negative regulation of feeding behavior
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042755 ! eating behavior
relationship: negatively_regulates GO:0042755 ! eating behavior
created_by: sl
creation_date: 2015-03-05T20:40:28Z

[Term]
id: GO:1904000
name: positive regulation of eating behavior
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of eating behavior." [GO_REF:0000058, GOC:TermGenie, PMID:11961051]
synonym: "activation of eating behavior" NARROW [GOC:TermGenie]
synonym: "activation of eating behaviour" NARROW [GOC:TermGenie]
synonym: "positive regulation of eating behaviour" EXACT [GOC:TermGenie]
synonym: "up regulation of eating behavior" EXACT [GOC:TermGenie]
synonym: "up regulation of eating behaviour" EXACT [GOC:TermGenie]
synonym: "up-regulation of eating behavior" EXACT [GOC:TermGenie]
synonym: "up-regulation of eating behaviour" EXACT [GOC:TermGenie]
synonym: "upregulation of eating behavior" EXACT [GOC:TermGenie]
synonym: "upregulation of eating behaviour" EXACT [GOC:TermGenie]
is_a: GO:1903998 ! regulation of eating behavior
is_a: GO:2000253 ! positive regulation of feeding behavior
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042755 ! eating behavior
relationship: positively_regulates GO:0042755 ! eating behavior
created_by: sl
creation_date: 2015-03-05T20:40:35Z

[Term]
id: GO:1904001
name: positive regulation of pyrimidine-containing compound salvage by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A positive regulation of transcription from RNA polymerase II promoter that results in positive regulation of pyrimidine-containing compound salvage." [GO_REF:0000063, GOC:al, GOC:TermGenie, PMID:23695302]
synonym: "activation of pyrimidine salvage by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "activation of pyrimidine-containing compound salvage by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "positive regulation of pyrimidine salvage by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "up regulation of pyrimidine salvage by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "up regulation of pyrimidine-containing compound salvage by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of pyrimidine salvage by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "up-regulation of pyrimidine-containing compound salvage by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of pyrimidine salvage by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "upregulation of pyrimidine-containing compound salvage by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
is_a: GO:1903930 ! regulation of pyrimidine-containing compound salvage
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: positively_regulates GO:0100068 ! positive regulation of pyrimidine-containing compound salvage by transcription from RNA polymerase II promoter
relationship: positively_regulates GO:0100068 ! positive regulation of pyrimidine-containing compound salvage by transcription from RNA polymerase II promoter
created_by: pr
creation_date: 2015-03-05T21:25:42Z

[Term]
id: GO:1904002
name: regulation of sebum secreting cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sebum secreting cell proliferation." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:16901790]
synonym: "regulation of sebocyte proliferation" RELATED [GOC:TermGenie]
is_a: GO:0042127 ! regulation of cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990654 ! sebum secreting cell proliferation
relationship: regulates GO:1990654 ! sebum secreting cell proliferation
created_by: hjd
creation_date: 2015-03-06T16:19:44Z

[Term]
id: GO:1904003
name: negative regulation of sebum secreting cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sebum secreting cell proliferation." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:16901790]
synonym: "down regulation of sebocyte proliferation" RELATED [GOC:TermGenie]
synonym: "down regulation of sebum secreting cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of sebocyte proliferation" RELATED [GOC:TermGenie]
synonym: "down-regulation of sebum secreting cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of sebocyte proliferation" RELATED [GOC:TermGenie]
synonym: "downregulation of sebum secreting cell proliferation" EXACT [GOC:TermGenie]
synonym: "inhibition of sebocyte proliferation" RELATED [GOC:TermGenie]
synonym: "inhibition of sebum secreting cell proliferation" NARROW [GOC:TermGenie]
synonym: "negative regulation of sebocyte proliferation" RELATED [GOC:TermGenie]
is_a: GO:0008285 ! negative regulation of cell proliferation
is_a: GO:1904002 ! regulation of sebum secreting cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990654 ! sebum secreting cell proliferation
relationship: negatively_regulates GO:1990654 ! sebum secreting cell proliferation
created_by: hjd
creation_date: 2015-03-06T16:19:50Z

[Term]
id: GO:1904004
name: positive regulation of sebum secreting cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sebum secreting cell proliferation." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:16901790]
synonym: "activation of sebocyte proliferation" RELATED [GOC:TermGenie]
synonym: "activation of sebum secreting cell proliferation" NARROW [GOC:TermGenie]
synonym: "positive regulation of sebocyte proliferation" RELATED [GOC:TermGenie]
synonym: "up regulation of sebocyte proliferation" RELATED [GOC:TermGenie]
synonym: "up regulation of sebum secreting cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of sebocyte proliferation" RELATED [GOC:TermGenie]
synonym: "up-regulation of sebum secreting cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of sebocyte proliferation" RELATED [GOC:TermGenie]
synonym: "upregulation of sebum secreting cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0008284 ! positive regulation of cell proliferation
is_a: GO:1904002 ! regulation of sebum secreting cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990654 ! sebum secreting cell proliferation
relationship: positively_regulates GO:1990654 ! sebum secreting cell proliferation
created_by: hjd
creation_date: 2015-03-06T16:19:56Z

[Term]
id: GO:1904005
name: regulation of phospholipase D activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phospholipase D activity." [GO_REF:0000059, GOC:TermGenie, PMID:11211872]
synonym: "regulation of choline phosphatase activity" EXACT [GOC:TermGenie]
synonym: "regulation of lecithinase D activity" EXACT [GOC:TermGenie]
synonym: "regulation of lipophosphodiesterase II activity" EXACT [GOC:TermGenie]
synonym: "regulation of phosphatidylcholine phosphatidohydrolase activity" EXACT [GOC:TermGenie]
is_a: GO:0010517 ! regulation of phospholipase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004630 ! phospholipase D activity
relationship: regulates GO:0004630 ! phospholipase D activity
created_by: sl
creation_date: 2015-03-06T17:20:05Z

[Term]
id: GO:1904006
name: negative regulation of phospholipase D activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of phospholipase D activity." [GO_REF:0000059, GOC:TermGenie, PMID:11211872]
synonym: "down regulation of choline phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of lecithinase D activity" EXACT [GOC:TermGenie]
synonym: "down regulation of lipophosphodiesterase II activity" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphatidylcholine phosphatidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of phospholipase D activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of choline phosphatase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of lecithinase D activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of lipophosphodiesterase II activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphatidylcholine phosphatidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of phospholipase D activity" EXACT [GOC:TermGenie]
synonym: "downregulation of choline phosphatase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of lecithinase D activity" EXACT [GOC:TermGenie]
synonym: "downregulation of lipophosphodiesterase II activity" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphatidylcholine phosphatidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of phospholipase D activity" EXACT [GOC:TermGenie]
synonym: "inhibition of choline phosphatase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of lecithinase D activity" NARROW [GOC:TermGenie]
synonym: "inhibition of lipophosphodiesterase II activity" NARROW [GOC:TermGenie]
synonym: "inhibition of phosphatidylcholine phosphatidohydrolase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of phospholipase D activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of choline phosphatase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of lecithinase D activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of lipophosphodiesterase II activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphatidylcholine phosphatidohydrolase activity" EXACT [GOC:TermGenie]
is_a: GO:0010519 ! negative regulation of phospholipase activity
is_a: GO:1904005 ! regulation of phospholipase D activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004630 ! phospholipase D activity
relationship: negatively_regulates GO:0004630 ! phospholipase D activity
created_by: sl
creation_date: 2015-03-06T17:20:11Z

[Term]
id: GO:1904007
name: positive regulation of phospholipase D activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phospholipase D activity." [GO_REF:0000059, GOC:TermGenie, PMID:11211872]
synonym: "activation of choline phosphatase activity" NARROW [GOC:TermGenie]
synonym: "activation of lecithinase D activity" NARROW [GOC:TermGenie]
synonym: "activation of lipophosphodiesterase II activity" NARROW [GOC:TermGenie]
synonym: "activation of phosphatidylcholine phosphatidohydrolase activity" NARROW [GOC:TermGenie]
synonym: "activation of phospholipase D activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of choline phosphatase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of lecithinase D activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of lipophosphodiesterase II activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphatidylcholine phosphatidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of choline phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of lecithinase D activity" EXACT [GOC:TermGenie]
synonym: "up regulation of lipophosphodiesterase II activity" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphatidylcholine phosphatidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of phospholipase D activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of choline phosphatase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of lecithinase D activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of lipophosphodiesterase II activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphatidylcholine phosphatidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of phospholipase D activity" EXACT [GOC:TermGenie]
synonym: "upregulation of choline phosphatase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of lecithinase D activity" EXACT [GOC:TermGenie]
synonym: "upregulation of lipophosphodiesterase II activity" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphatidylcholine phosphatidohydrolase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of phospholipase D activity" EXACT [GOC:TermGenie]
is_a: GO:0010518 ! positive regulation of phospholipase activity
is_a: GO:1904005 ! regulation of phospholipase D activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004630 ! phospholipase D activity
relationship: positively_regulates GO:0004630 ! phospholipase D activity
created_by: sl
creation_date: 2015-03-06T17:20:17Z

[Term]
id: GO:1904008
name: response to monosodium glutamate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosodium glutamate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20704590]
is_a: GO:1902074 ! response to salt
created_by: sl
creation_date: 2015-03-06T18:26:34Z

[Term]
id: GO:1904009
name: cellular response to monosodium glutamate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosodium glutamate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20704590]
is_a: GO:1902075 ! cellular response to salt
is_a: GO:1904008 ! response to monosodium glutamate
created_by: sl
creation_date: 2015-03-06T18:26:40Z

[Term]
id: GO:1904010
name: response to Aroclor 1254
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an Aroclor 1254 stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18602130]
is_a: GO:0042221 ! response to chemical
created_by: sl
creation_date: 2015-03-06T18:35:00Z

[Term]
id: GO:1904011
name: cellular response to Aroclor 1254
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an Aroclor 1254 stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18602130]
is_a: GO:0070887 ! cellular response to chemical stimulus
is_a: GO:1904010 ! response to Aroclor 1254
created_by: sl
creation_date: 2015-03-06T18:35:06Z

[Term]
id: GO:1904012
name: platinum binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with platinum." [GO_REF:0000067, GOC:TermGenie, PMID:10089464]
is_a: GO:0005488 ! binding
created_by: sl
creation_date: 2015-03-06T19:07:37Z

[Term]
id: GO:1904013
name: xenon atom binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with xenon atom." [GO_REF:0000067, GOC:TermGenie, PMID:10089464]
is_a: GO:0005488 ! binding
created_by: sl
creation_date: 2015-03-06T19:07:43Z

[Term]
id: GO:1904014
name: response to serotonin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a serotonin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:1505525]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0071867 ! response to monoamine
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: sl
creation_date: 2015-03-06T19:33:54Z

[Term]
id: GO:1904015
name: cellular response to serotonin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a serotonin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:1505525]
is_a: GO:0071242 ! cellular response to ammonium ion
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071868 ! cellular response to monoamine stimulus
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1904014 ! response to serotonin
created_by: sl
creation_date: 2015-03-06T19:34:00Z

[Term]
id: GO:1904016
name: response to Thyroglobulin triiodothyronine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Thyroglobulin triiodothyronine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:7531505]
is_a: GO:0010033 ! response to organic substance
created_by: sl
creation_date: 2015-03-06T19:34:07Z

[Term]
id: GO:1904017
name: cellular response to Thyroglobulin triiodothyronine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Thyroglobulin triiodothyronine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:7531505]
is_a: GO:0070887 ! cellular response to chemical stimulus
is_a: GO:1904016 ! response to Thyroglobulin triiodothyronine
created_by: sl
creation_date: 2015-03-06T19:34:13Z

[Term]
id: GO:1904018
name: positive regulation of vasculature development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vasculature development." [GO_REF:0000058, GOC:TermGenie, PMID:21472453]
synonym: "activation of vascular system development" RELATED [GOC:TermGenie]
synonym: "activation of vasculature development" NARROW [GOC:TermGenie]
synonym: "positive regulation of vascular system development" RELATED [GOC:TermGenie]
synonym: "up regulation of vascular system development" RELATED [GOC:TermGenie]
synonym: "up regulation of vasculature development" EXACT [GOC:TermGenie]
synonym: "up-regulation of vascular system development" RELATED [GOC:TermGenie]
synonym: "up-regulation of vasculature development" EXACT [GOC:TermGenie]
synonym: "upregulation of vascular system development" RELATED [GOC:TermGenie]
synonym: "upregulation of vasculature development" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1901342 ! regulation of vasculature development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001944 ! vasculature development
relationship: positively_regulates GO:0001944 ! vasculature development
created_by: sl
creation_date: 2015-03-06T22:17:04Z

[Term]
id: GO:1904019
name: epithelial cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in an epithelial cell." [GO_REF:0000085, GOC:TermGenie, PMID:19137015]
synonym: "epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "epitheliocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "epitheliocyte apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0006915 ! apoptotic process
created_by: sl
creation_date: 2015-03-06T22:27:17Z

[Term]
id: GO:1904020
name: regulation of G-protein coupled receptor internalization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of G-protein coupled receptor internalization." [GO_REF:0000058, GOC:TermGenie, PMID:24732013]
is_a: GO:0002090 ! regulation of receptor internalization
is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002031 ! G-protein coupled receptor internalization
relationship: regulates GO:0002031 ! G-protein coupled receptor internalization
created_by: pga
creation_date: 2015-03-10T17:10:45Z

[Term]
id: GO:1904021
name: negative regulation of G-protein coupled receptor internalization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of G-protein coupled receptor internalization." [GO_REF:0000058, GOC:TermGenie, PMID:24732013]
synonym: "down regulation of G-protein coupled receptor internalization" EXACT [GOC:TermGenie]
synonym: "down-regulation of G-protein coupled receptor internalization" EXACT [GOC:TermGenie]
synonym: "downregulation of G-protein coupled receptor internalization" EXACT [GOC:TermGenie]
synonym: "inhibition of G-protein coupled receptor internalization" NARROW [GOC:TermGenie]
is_a: GO:0002091 ! negative regulation of receptor internalization
is_a: GO:0045745 ! positive regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:1904020 ! regulation of G-protein coupled receptor internalization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002031 ! G-protein coupled receptor internalization
relationship: negatively_regulates GO:0002031 ! G-protein coupled receptor internalization
created_by: pga
creation_date: 2015-03-10T17:10:50Z

[Term]
id: GO:1904022
name: positive regulation of G-protein coupled receptor internalization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of G-protein coupled receptor internalization." [GO_REF:0000058, GOC:TermGenie, PMID:24732013]
synonym: "activation of G-protein coupled receptor internalization" NARROW [GOC:TermGenie]
synonym: "up regulation of G-protein coupled receptor internalization" EXACT [GOC:TermGenie]
synonym: "up-regulation of G-protein coupled receptor internalization" EXACT [GOC:TermGenie]
synonym: "upregulation of G-protein coupled receptor internalization" EXACT [GOC:TermGenie]
is_a: GO:0002092 ! positive regulation of receptor internalization
is_a: GO:1904020 ! regulation of G-protein coupled receptor internalization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002031 ! G-protein coupled receptor internalization
relationship: positively_regulates GO:0002031 ! G-protein coupled receptor internalization
created_by: pga
creation_date: 2015-03-10T17:10:56Z

[Term]
id: GO:1904023
name: regulation of glucose catabolic process to lactate via pyruvate
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glucose catabolic process to lactate via pyruvate." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:20935145]
synonym: "regulation of glucose fermentation to lactate via pyruvate" EXACT [GOC:TermGenie]
synonym: "regulation of homofermentation" EXACT [GOC:TermGenie]
synonym: "regulation of homofermentative lactate fermentation" EXACT [GOC:TermGenie]
synonym: "regulation of homofermentative pathway" EXACT [GOC:TermGenie]
synonym: "regulation of homolactate fermentation" EXACT [GOC:TermGenie]
synonym: "regulation of homolactic fermentation" EXACT [GOC:TermGenie]
is_a: GO:0010906 ! regulation of glucose metabolic process
is_a: GO:0033121 ! regulation of purine nucleotide catabolic process
is_a: GO:0043465 ! regulation of fermentation
is_a: GO:0043470 ! regulation of carbohydrate catabolic process
is_a: GO:1902688 ! regulation of NAD metabolic process
is_a: GO:1903578 ! regulation of ATP metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019661 ! glucose catabolic process to lactate via pyruvate
relationship: regulates GO:0019661 ! glucose catabolic process to lactate via pyruvate
created_by: dph
creation_date: 2015-03-11T16:57:32Z

[Term]
id: GO:1904024
name: negative regulation of glucose catabolic process to lactate via pyruvate
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glucose catabolic process to lactate via pyruvate." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:20935145]
synonym: "down regulation of glucose catabolic process to lactate via pyruvate" EXACT [GOC:TermGenie]
synonym: "down regulation of glucose fermentation to lactate via pyruvate" EXACT [GOC:TermGenie]
synonym: "down regulation of homofermentation" EXACT [GOC:TermGenie]
synonym: "down regulation of homofermentative lactate fermentation" EXACT [GOC:TermGenie]
synonym: "down regulation of homofermentative pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of homolactate fermentation" EXACT [GOC:TermGenie]
synonym: "down regulation of homolactic fermentation" EXACT [GOC:TermGenie]
synonym: "down-regulation of glucose catabolic process to lactate via pyruvate" EXACT [GOC:TermGenie]
synonym: "down-regulation of glucose fermentation to lactate via pyruvate" EXACT [GOC:TermGenie]
synonym: "down-regulation of homofermentation" EXACT [GOC:TermGenie]
synonym: "down-regulation of homofermentative lactate fermentation" EXACT [GOC:TermGenie]
synonym: "down-regulation of homofermentative pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of homolactate fermentation" EXACT [GOC:TermGenie]
synonym: "down-regulation of homolactic fermentation" EXACT [GOC:TermGenie]
synonym: "downregulation of glucose catabolic process to lactate via pyruvate" EXACT [GOC:TermGenie]
synonym: "downregulation of glucose fermentation to lactate via pyruvate" EXACT [GOC:TermGenie]
synonym: "downregulation of homofermentation" EXACT [GOC:TermGenie]
synonym: "downregulation of homofermentative lactate fermentation" EXACT [GOC:TermGenie]
synonym: "downregulation of homofermentative pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of homolactate fermentation" EXACT [GOC:TermGenie]
synonym: "downregulation of homolactic fermentation" EXACT [GOC:TermGenie]
synonym: "inhibition of glucose catabolic process to lactate via pyruvate" NARROW [GOC:TermGenie]
synonym: "inhibition of glucose fermentation to lactate via pyruvate" NARROW [GOC:TermGenie]
synonym: "inhibition of homofermentation" NARROW [GOC:TermGenie]
synonym: "inhibition of homofermentative lactate fermentation" NARROW [GOC:TermGenie]
synonym: "inhibition of homofermentative pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of homolactate fermentation" NARROW [GOC:TermGenie]
synonym: "inhibition of homolactic fermentation" NARROW [GOC:TermGenie]
synonym: "negative regulation of glucose fermentation to lactate via pyruvate" EXACT [GOC:TermGenie]
synonym: "negative regulation of homofermentation" EXACT [GOC:TermGenie]
synonym: "negative regulation of homofermentative lactate fermentation" EXACT [GOC:TermGenie]
synonym: "negative regulation of homofermentative pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of homolactate fermentation" EXACT [GOC:TermGenie]
synonym: "negative regulation of homolactic fermentation" EXACT [GOC:TermGenie]
is_a: GO:0033122 ! negative regulation of purine nucleotide catabolic process
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:1901003 ! negative regulation of fermentation
is_a: GO:1902689 ! negative regulation of NAD metabolic process
is_a: GO:1903579 ! negative regulation of ATP metabolic process
is_a: GO:1904023 ! regulation of glucose catabolic process to lactate via pyruvate
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019661 ! glucose catabolic process to lactate via pyruvate
relationship: negatively_regulates GO:0019661 ! glucose catabolic process to lactate via pyruvate
created_by: dph
creation_date: 2015-03-11T16:57:38Z

[Term]
id: GO:1904025
name: positive regulation of glucose catabolic process to lactate via pyruvate
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glucose catabolic process to lactate via pyruvate." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:20935145]
synonym: "activation of glucose catabolic process to lactate via pyruvate" NARROW [GOC:TermGenie]
synonym: "activation of glucose fermentation to lactate via pyruvate" NARROW [GOC:TermGenie]
synonym: "activation of homofermentation" NARROW [GOC:TermGenie]
synonym: "activation of homofermentative lactate fermentation" NARROW [GOC:TermGenie]
synonym: "activation of homofermentative pathway" NARROW [GOC:TermGenie]
synonym: "activation of homolactate fermentation" NARROW [GOC:TermGenie]
synonym: "activation of homolactic fermentation" NARROW [GOC:TermGenie]
synonym: "positive regulation of glucose fermentation to lactate via pyruvate" EXACT [GOC:TermGenie]
synonym: "positive regulation of homofermentation" EXACT [GOC:TermGenie]
synonym: "positive regulation of homofermentative lactate fermentation" EXACT [GOC:TermGenie]
synonym: "positive regulation of homofermentative pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of homolactate fermentation" EXACT [GOC:TermGenie]
synonym: "positive regulation of homolactic fermentation" EXACT [GOC:TermGenie]
synonym: "up regulation of glucose catabolic process to lactate via pyruvate" EXACT [GOC:TermGenie]
synonym: "up regulation of glucose fermentation to lactate via pyruvate" EXACT [GOC:TermGenie]
synonym: "up regulation of homofermentation" EXACT [GOC:TermGenie]
synonym: "up regulation of homofermentative lactate fermentation" EXACT [GOC:TermGenie]
synonym: "up regulation of homofermentative pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of homolactate fermentation" EXACT [GOC:TermGenie]
synonym: "up regulation of homolactic fermentation" EXACT [GOC:TermGenie]
synonym: "up-regulation of glucose catabolic process to lactate via pyruvate" EXACT [GOC:TermGenie]
synonym: "up-regulation of glucose fermentation to lactate via pyruvate" EXACT [GOC:TermGenie]
synonym: "up-regulation of homofermentation" EXACT [GOC:TermGenie]
synonym: "up-regulation of homofermentative lactate fermentation" EXACT [GOC:TermGenie]
synonym: "up-regulation of homofermentative pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of homolactate fermentation" EXACT [GOC:TermGenie]
synonym: "up-regulation of homolactic fermentation" EXACT [GOC:TermGenie]
synonym: "upregulation of glucose catabolic process to lactate via pyruvate" EXACT [GOC:TermGenie]
synonym: "upregulation of glucose fermentation to lactate via pyruvate" EXACT [GOC:TermGenie]
synonym: "upregulation of homofermentation" EXACT [GOC:TermGenie]
synonym: "upregulation of homofermentative lactate fermentation" EXACT [GOC:TermGenie]
synonym: "upregulation of homofermentative pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of homolactate fermentation" EXACT [GOC:TermGenie]
synonym: "upregulation of homolactic fermentation" EXACT [GOC:TermGenie]
is_a: GO:0010907 ! positive regulation of glucose metabolic process
is_a: GO:0033123 ! positive regulation of purine nucleotide catabolic process
is_a: GO:1902690 ! positive regulation of NAD metabolic process
is_a: GO:1903580 ! positive regulation of ATP metabolic process
is_a: GO:1904023 ! regulation of glucose catabolic process to lactate via pyruvate
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0019661 ! glucose catabolic process to lactate via pyruvate
relationship: positively_regulates GO:0019661 ! glucose catabolic process to lactate via pyruvate
created_by: dph
creation_date: 2015-03-11T16:57:44Z

[Term]
id: GO:1904026
name: regulation of collagen fibril organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of collagen fibril organization." [GO_REF:0000058, GOC:TermGenie, PMID:25451920]
synonym: "regulation of collagen fibril organisation" EXACT [GOC:TermGenie]
synonym: "regulation of collagen fibrillogenesis" RELATED []
synonym: "regulation of fibrillar collagen organization" EXACT [GOC:TermGenie]
is_a: GO:1903053 ! regulation of extracellular matrix organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030199 ! collagen fibril organization
relationship: regulates GO:0030199 ! collagen fibril organization
created_by: Anne.Estreicher
creation_date: 2015-03-12T12:36:52Z

[Term]
id: GO:1904027
name: negative regulation of collagen fibril organization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of collagen fibril organization." [GO_REF:0000058, GOC:TermGenie, PMID:25451920]
synonym: "down regulation of collagen fibril organisation" EXACT [GOC:TermGenie]
synonym: "down regulation of collagen fibril organization" EXACT [GOC:TermGenie]
synonym: "down regulation of fibrillar collagen organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of collagen fibril organisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of collagen fibril organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of fibrillar collagen organization" EXACT [GOC:TermGenie]
synonym: "downregulation of collagen fibril organisation" EXACT [GOC:TermGenie]
synonym: "downregulation of collagen fibril organization" EXACT [GOC:TermGenie]
synonym: "downregulation of fibrillar collagen organization" EXACT [GOC:TermGenie]
synonym: "inhibition of collagen fibril organisation" NARROW [GOC:TermGenie]
synonym: "inhibition of collagen fibril organization" NARROW [GOC:TermGenie]
synonym: "inhibition of fibrillar collagen organization" NARROW [GOC:TermGenie]
synonym: "negative regulation of collagen fibril organisation" EXACT [GOC:TermGenie]
synonym: "negative regulation of fibrillar collagen organization" EXACT [GOC:TermGenie]
is_a: GO:1903054 ! negative regulation of extracellular matrix organization
is_a: GO:1904026 ! regulation of collagen fibril organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030199 ! collagen fibril organization
relationship: negatively_regulates GO:0030199 ! collagen fibril organization
created_by: Anne.Estreicher
creation_date: 2015-03-12T12:36:59Z

[Term]
id: GO:1904028
name: positive regulation of collagen fibril organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of collagen fibril organization." [GO_REF:0000058, GOC:TermGenie, PMID:25451920]
synonym: "activation of collagen fibril organisation" NARROW [GOC:TermGenie]
synonym: "activation of collagen fibril organization" NARROW [GOC:TermGenie]
synonym: "activation of fibrillar collagen organization" NARROW [GOC:TermGenie]
synonym: "positive regulation of collagen fibril organisation" EXACT [GOC:TermGenie]
synonym: "positive regulation of fibrillar collagen organization" EXACT [GOC:TermGenie]
synonym: "up regulation of collagen fibril organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of collagen fibril organization" EXACT [GOC:TermGenie]
synonym: "up regulation of fibrillar collagen organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of collagen fibril organisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of collagen fibril organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of fibrillar collagen organization" EXACT [GOC:TermGenie]
synonym: "upregulation of collagen fibril organisation" EXACT [GOC:TermGenie]
synonym: "upregulation of collagen fibril organization" EXACT [GOC:TermGenie]
synonym: "upregulation of fibrillar collagen organization" EXACT [GOC:TermGenie]
is_a: GO:1903055 ! positive regulation of extracellular matrix organization
is_a: GO:1904026 ! regulation of collagen fibril organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030199 ! collagen fibril organization
relationship: positively_regulates GO:0030199 ! collagen fibril organization
created_by: Anne.Estreicher
creation_date: 2015-03-12T12:37:06Z

[Term]
id: GO:1904029
name: regulation of cyclin-dependent protein kinase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cyclin-dependent protein kinase activity." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:22995177]
is_a: GO:0045859 ! regulation of protein kinase activity
is_a: GO:0051726 ! regulation of cell cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097472 ! cyclin-dependent protein kinase activity
relationship: regulates GO:0097472 ! cyclin-dependent protein kinase activity
created_by: als
creation_date: 2015-03-13T15:43:38Z

[Term]
id: GO:1904030
name: negative regulation of cyclin-dependent protein kinase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cyclin-dependent protein kinase activity." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:22995177]
synonym: "down regulation of cyclin-dependent protein kinase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of cyclin-dependent protein kinase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of cyclin-dependent protein kinase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of cyclin-dependent protein kinase activity" NARROW [GOC:TermGenie]
is_a: GO:0006469 ! negative regulation of protein kinase activity
is_a: GO:1904029 ! regulation of cyclin-dependent protein kinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097472 ! cyclin-dependent protein kinase activity
relationship: negatively_regulates GO:0097472 ! cyclin-dependent protein kinase activity
created_by: als
creation_date: 2015-03-13T15:43:44Z

[Term]
id: GO:1904031
name: positive regulation of cyclin-dependent protein kinase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cyclin-dependent protein kinase activity." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:22995177]
synonym: "activation of cyclin-dependent protein kinase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of cyclin-dependent protein kinase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of cyclin-dependent protein kinase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of cyclin-dependent protein kinase activity" EXACT [GOC:TermGenie]
is_a: GO:0045860 ! positive regulation of protein kinase activity
is_a: GO:1904029 ! regulation of cyclin-dependent protein kinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097472 ! cyclin-dependent protein kinase activity
relationship: positively_regulates GO:0097472 ! cyclin-dependent protein kinase activity
created_by: als
creation_date: 2015-03-13T15:43:50Z

[Term]
id: GO:1904032
name: regulation of t-SNARE clustering
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of t-SNARE clustering." [GO_REF:0000058, GOC:TermGenie, PMID:22528485]
is_a: GO:0051128 ! regulation of cellular component organization
is_a: GO:1903827 ! regulation of cellular protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990656 ! t-SNARE clustering
relationship: regulates GO:1990656 ! t-SNARE clustering
created_by: sl
creation_date: 2015-03-13T21:21:38Z

[Term]
id: GO:1904033
name: negative regulation of t-SNARE clustering
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of t-SNARE clustering." [GO_REF:0000058, GOC:TermGenie, PMID:22528485]
synonym: "down regulation of t-SNARE clustering" EXACT [GOC:TermGenie]
synonym: "down-regulation of t-SNARE clustering" EXACT [GOC:TermGenie]
synonym: "downregulation of t-SNARE clustering" EXACT [GOC:TermGenie]
synonym: "inhibition of t-SNARE clustering" NARROW [GOC:TermGenie]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1903828 ! negative regulation of cellular protein localization
is_a: GO:1904032 ! regulation of t-SNARE clustering
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990656 ! t-SNARE clustering
relationship: negatively_regulates GO:1990656 ! t-SNARE clustering
created_by: sl
creation_date: 2015-03-13T21:21:44Z

[Term]
id: GO:1904034
name: positive regulation of t-SNARE clustering
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of t-SNARE clustering." [GO_REF:0000058, GOC:TermGenie, PMID:22528485]
synonym: "activation of t-SNARE clustering" NARROW [GOC:TermGenie]
synonym: "up regulation of t-SNARE clustering" EXACT [GOC:TermGenie]
synonym: "up-regulation of t-SNARE clustering" EXACT [GOC:TermGenie]
synonym: "upregulation of t-SNARE clustering" EXACT [GOC:TermGenie]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1903829 ! positive regulation of cellular protein localization
is_a: GO:1904032 ! regulation of t-SNARE clustering
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990656 ! t-SNARE clustering
relationship: positively_regulates GO:1990656 ! t-SNARE clustering
created_by: sl
creation_date: 2015-03-13T21:21:50Z

[Term]
id: GO:1904035
name: regulation of epithelial cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of epithelial cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:19137015]
synonym: "regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0042981 ! regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1904019 ! epithelial cell apoptotic process
relationship: regulates GO:1904019 ! epithelial cell apoptotic process
created_by: sl
creation_date: 2015-03-13T22:05:41Z

[Term]
id: GO:1904036
name: negative regulation of epithelial cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:19137015]
synonym: "down regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "inhibition of epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of epithelial cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "inhibition of epitheliocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of epitheliocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0043066 ! negative regulation of apoptotic process
is_a: GO:1904035 ! regulation of epithelial cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1904019 ! epithelial cell apoptotic process
relationship: negatively_regulates GO:1904019 ! epithelial cell apoptotic process
created_by: sl
creation_date: 2015-03-13T22:05:47Z

[Term]
id: GO:1904037
name: positive regulation of epithelial cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of epithelial cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:19137015]
synonym: "activation of epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of epithelial cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "activation of epitheliocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of epitheliocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0043065 ! positive regulation of apoptotic process
is_a: GO:1904035 ! regulation of epithelial cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1904019 ! epithelial cell apoptotic process
relationship: positively_regulates GO:1904019 ! epithelial cell apoptotic process
created_by: sl
creation_date: 2015-03-13T22:05:53Z

[Term]
id: GO:1904038
name: regulation of ferrous iron export
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of iron(2+) export." [GO_REF:0000058, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:15514116]
synonym: "regulation of ferrous iron export" EXACT [GOC:TermGenie]
synonym: "regulation of iron(2+) export" EXACT []
is_a: GO:0034759 ! regulation of iron ion transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1903988 ! ferrous iron export
relationship: regulates GO:1903988 ! ferrous iron export
created_by: klaus.mitchell.14
creation_date: 2015-03-16T15:36:37Z

[Term]
id: GO:1904039
name: negative regulation of ferrous iron export
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of iron(2+) export." [GO_REF:0000058, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:15514116]
synonym: "down regulation of ferrous iron export" EXACT [GOC:TermGenie]
synonym: "down regulation of iron(2+) export" EXACT [GOC:TermGenie]
synonym: "down-regulation of ferrous iron export" EXACT [GOC:TermGenie]
synonym: "down-regulation of iron(2+) export" EXACT [GOC:TermGenie]
synonym: "downregulation of ferrous iron export" EXACT [GOC:TermGenie]
synonym: "downregulation of iron(2+) export" EXACT [GOC:TermGenie]
synonym: "inhibition of ferrous iron export" NARROW [GOC:TermGenie]
synonym: "inhibition of iron(2+) export" NARROW [GOC:TermGenie]
synonym: "negative regulation of ferrous iron export" EXACT [GOC:TermGenie]
synonym: "negative regulation of iron(2+) export" EXACT []
is_a: GO:0034760 ! negative regulation of iron ion transmembrane transport
is_a: GO:1904038 ! regulation of ferrous iron export
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1903988 ! ferrous iron export
relationship: negatively_regulates GO:1903988 ! ferrous iron export
created_by: klaus.mitchell.14
creation_date: 2015-03-16T15:36:43Z

[Term]
id: GO:1904040
name: positive regulation of ferrous iron export
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of iron(2+) export." [GO_REF:0000058, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:15514116]
synonym: "activation of ferrous iron export" NARROW [GOC:TermGenie]
synonym: "activation of iron(2+) export" NARROW [GOC:TermGenie]
synonym: "positive regulation of ferrous iron export" EXACT [GOC:TermGenie]
synonym: "positive regulation of iron(2+) export" EXACT []
synonym: "up regulation of ferrous iron export" EXACT [GOC:TermGenie]
synonym: "up regulation of iron(2+) export" EXACT [GOC:TermGenie]
synonym: "up-regulation of ferrous iron export" EXACT [GOC:TermGenie]
synonym: "up-regulation of iron(2+) export" EXACT [GOC:TermGenie]
synonym: "upregulation of ferrous iron export" EXACT [GOC:TermGenie]
synonym: "upregulation of iron(2+) export" EXACT [GOC:TermGenie]
is_a: GO:0034761 ! positive regulation of iron ion transmembrane transport
is_a: GO:1904038 ! regulation of ferrous iron export
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1903988 ! ferrous iron export
relationship: positively_regulates GO:1903988 ! ferrous iron export
created_by: klaus.mitchell.14
creation_date: 2015-03-16T15:36:49Z

[Term]
id: GO:1904041
name: regulation of cystathionine beta-synthase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cystathionine beta-synthase activity." [GO_REF:0000059, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:24416422]
synonym: "regulation of beta-thionase activity" EXACT [GOC:TermGenie]
synonym: "regulation of L-serine hydro-lyase (adding homocysteine)" EXACT [GOC:TermGenie]
synonym: "regulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" EXACT [GOC:TermGenie]
synonym: "regulation of methylcysteine synthase activity" EXACT [GOC:TermGenie]
synonym: "regulation of serine sulfhydrase activity" EXACT [GOC:TermGenie]
synonym: "regulation of serine sulfhydrylase activity" EXACT [GOC:TermGenie]
is_a: GO:0051339 ! regulation of lyase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004122 ! cystathionine beta-synthase activity
relationship: regulates GO:0004122 ! cystathionine beta-synthase activity
created_by: hadil.alrohaif.14
creation_date: 2015-03-16T15:52:41Z

[Term]
id: GO:1904042
name: negative regulation of cystathionine beta-synthase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cystathionine beta-synthase activity." [GO_REF:0000059, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:24416422]
synonym: "down regulation of beta-thionase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of cystathionine beta-synthase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of L-serine hydro-lyase (adding homocysteine)" EXACT [GOC:TermGenie]
synonym: "down regulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" EXACT [GOC:TermGenie]
synonym: "down regulation of methylcysteine synthase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of serine sulfhydrase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of serine sulfhydrylase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of beta-thionase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of cystathionine beta-synthase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of L-serine hydro-lyase (adding homocysteine)" EXACT [GOC:TermGenie]
synonym: "down-regulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" EXACT [GOC:TermGenie]
synonym: "down-regulation of methylcysteine synthase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of serine sulfhydrase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of serine sulfhydrylase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of beta-thionase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of cystathionine beta-synthase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of L-serine hydro-lyase (adding homocysteine)" EXACT [GOC:TermGenie]
synonym: "downregulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" EXACT [GOC:TermGenie]
synonym: "downregulation of methylcysteine synthase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of serine sulfhydrase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of serine sulfhydrylase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of beta-thionase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of cystathionine beta-synthase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of L-serine hydro-lyase (adding homocysteine)" NARROW [GOC:TermGenie]
synonym: "inhibition of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" NARROW [GOC:TermGenie]
synonym: "inhibition of methylcysteine synthase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of serine sulfhydrase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of serine sulfhydrylase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of beta-thionase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of L-serine hydro-lyase (adding homocysteine)" EXACT [GOC:TermGenie]
synonym: "negative regulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" EXACT [GOC:TermGenie]
synonym: "negative regulation of methylcysteine synthase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of serine sulfhydrase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of serine sulfhydrylase activity" EXACT [GOC:TermGenie]
is_a: GO:0051350 ! negative regulation of lyase activity
is_a: GO:1904041 ! regulation of cystathionine beta-synthase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004122 ! cystathionine beta-synthase activity
relationship: negatively_regulates GO:0004122 ! cystathionine beta-synthase activity
created_by: hadil.alrohaif.14
creation_date: 2015-03-16T15:52:47Z

[Term]
id: GO:1904043
name: positive regulation of cystathionine beta-synthase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cystathionine beta-synthase activity." [GO_REF:0000059, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:24416422]
synonym: "activation of beta-thionase activity" NARROW [GOC:TermGenie]
synonym: "activation of cystathionine beta-synthase activity" NARROW [GOC:TermGenie]
synonym: "activation of L-serine hydro-lyase (adding homocysteine)" NARROW [GOC:TermGenie]
synonym: "activation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" NARROW [GOC:TermGenie]
synonym: "activation of methylcysteine synthase activity" NARROW [GOC:TermGenie]
synonym: "activation of serine sulfhydrase activity" NARROW [GOC:TermGenie]
synonym: "activation of serine sulfhydrylase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of beta-thionase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of L-serine hydro-lyase (adding homocysteine)" EXACT [GOC:TermGenie]
synonym: "positive regulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" EXACT [GOC:TermGenie]
synonym: "positive regulation of methylcysteine synthase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of serine sulfhydrase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of serine sulfhydrylase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of beta-thionase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of cystathionine beta-synthase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of L-serine hydro-lyase (adding homocysteine)" EXACT [GOC:TermGenie]
synonym: "up regulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" EXACT [GOC:TermGenie]
synonym: "up regulation of methylcysteine synthase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of serine sulfhydrase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of serine sulfhydrylase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of beta-thionase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of cystathionine beta-synthase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-serine hydro-lyase (adding homocysteine)" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" EXACT [GOC:TermGenie]
synonym: "up-regulation of methylcysteine synthase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of serine sulfhydrase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of serine sulfhydrylase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of beta-thionase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of cystathionine beta-synthase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of L-serine hydro-lyase (adding homocysteine)" EXACT [GOC:TermGenie]
synonym: "upregulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" EXACT [GOC:TermGenie]
synonym: "upregulation of methylcysteine synthase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of serine sulfhydrase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of serine sulfhydrylase activity" EXACT [GOC:TermGenie]
is_a: GO:0051349 ! positive regulation of lyase activity
is_a: GO:1904041 ! regulation of cystathionine beta-synthase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004122 ! cystathionine beta-synthase activity
relationship: positively_regulates GO:0004122 ! cystathionine beta-synthase activity
created_by: hadil.alrohaif.14
creation_date: 2015-03-16T15:52:53Z

[Term]
id: GO:1904044
name: response to aldosterone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aldosterone stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:17644563]
is_a: GO:0051385 ! response to mineralocorticoid
is_a: GO:0097305 ! response to alcohol
is_a: GO:1901654 ! response to ketone
created_by: sl
creation_date: 2015-03-16T23:07:53Z

[Term]
id: GO:1904045
name: cellular response to aldosterone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aldosterone stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:17644563]
is_a: GO:0071389 ! cellular response to mineralocorticoid stimulus
is_a: GO:0097306 ! cellular response to alcohol
is_a: GO:1901655 ! cellular response to ketone
is_a: GO:1904044 ! response to aldosterone
created_by: sl
creation_date: 2015-03-16T23:07:59Z

[Term]
id: GO:1904046
name: negative regulation of vascular endothelial growth factor production
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial growth factor production." [GO_REF:0000058, GOC:TermGenie, PMID:19404486]
synonym: "down regulation of vascular endothelial growth factor production" EXACT [GOC:TermGenie]
synonym: "down regulation of VEGF production" EXACT [GOC:TermGenie]
synonym: "down-regulation of vascular endothelial growth factor production" EXACT [GOC:TermGenie]
synonym: "down-regulation of VEGF production" EXACT [GOC:TermGenie]
synonym: "downregulation of vascular endothelial growth factor production" EXACT [GOC:TermGenie]
synonym: "downregulation of VEGF production" EXACT [GOC:TermGenie]
synonym: "inhibition of vascular endothelial growth factor production" NARROW [GOC:TermGenie]
synonym: "inhibition of VEGF production" NARROW [GOC:TermGenie]
synonym: "negative regulation of VEGF production" EXACT [GOC:TermGenie]
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0010574 ! regulation of vascular endothelial growth factor production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010573 ! vascular endothelial growth factor production
relationship: negatively_regulates GO:0010573 ! vascular endothelial growth factor production
created_by: sl
creation_date: 2015-03-16T23:27:06Z

[Term]
id: GO:1904047
name: S-adenosyl-L-methionine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with S-adenosyl-L-methionine." [GO_REF:0000067, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:22985361]
is_a: GO:1901681 ! sulfur compound binding
created_by: hadil.alrohaif.14
creation_date: 2015-03-17T10:32:16Z

[Term]
id: GO:1904048
name: regulation of spontaneous neurotransmitter secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of spontaneous neurotransmitter secretion." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22314364]
comment: An example of this is PARK2 / parkin in human (O60260) in PMID:22314364 (inferred from mutant phenotype).
synonym: "regulation of stimulus-independent neurotransmitter secretion" EXACT [GOC:TermGenie]
is_a: GO:0046928 ! regulation of neurotransmitter secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061669 ! spontaneous neurotransmitter secretion
relationship: regulates GO:0061669 ! spontaneous neurotransmitter secretion
created_by: pad
creation_date: 2015-03-17T10:37:11Z

[Term]
id: GO:1904049
name: negative regulation of spontaneous neurotransmitter secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of spontaneous neurotransmitter secretion." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22314364]
comment: An example of this is PARK2 / parkin in human (O60260) in PMID:22314364 (inferred from mutant phenotype).
synonym: "down regulation of spontaneous neurotransmitter secretion" EXACT [GOC:TermGenie]
synonym: "down regulation of stimulus-independent neurotransmitter secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of spontaneous neurotransmitter secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of stimulus-independent neurotransmitter secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of spontaneous neurotransmitter secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of stimulus-independent neurotransmitter secretion" EXACT [GOC:TermGenie]
synonym: "inhibition of spontaneous neurotransmitter secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of stimulus-independent neurotransmitter secretion" NARROW [GOC:TermGenie]
synonym: "negative regulation of stimulus-independent neurotransmitter secretion" EXACT [GOC:TermGenie]
is_a: GO:0046929 ! negative regulation of neurotransmitter secretion
is_a: GO:1904048 ! regulation of spontaneous neurotransmitter secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061669 ! spontaneous neurotransmitter secretion
relationship: negatively_regulates GO:0061669 ! spontaneous neurotransmitter secretion
created_by: pad
creation_date: 2015-03-17T10:37:17Z

[Term]
id: GO:1904050
name: positive regulation of spontaneous neurotransmitter secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of spontaneous neurotransmitter secretion." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22314364]
comment: An example of this is PARK2 / parkin in human (O60260) in PMID:22314364 (inferred from mutant phenotype).
synonym: "activation of spontaneous neurotransmitter secretion" NARROW [GOC:TermGenie]
synonym: "activation of stimulus-independent neurotransmitter secretion" NARROW [GOC:TermGenie]
synonym: "positive regulation of stimulus-independent neurotransmitter secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of spontaneous neurotransmitter secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of stimulus-independent neurotransmitter secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of spontaneous neurotransmitter secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of stimulus-independent neurotransmitter secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of spontaneous neurotransmitter secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of stimulus-independent neurotransmitter secretion" EXACT [GOC:TermGenie]
is_a: GO:0001956 ! positive regulation of neurotransmitter secretion
is_a: GO:1904048 ! regulation of spontaneous neurotransmitter secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061669 ! spontaneous neurotransmitter secretion
relationship: positively_regulates GO:0061669 ! spontaneous neurotransmitter secretion
created_by: pad
creation_date: 2015-03-17T10:37:23Z

[Term]
id: GO:1904051
name: regulation of protein targeting to vacuole involved in autophagy
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein targeting to vacuole involved in autophagy." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22020285]
comment: An example of this is SMURF1 in human (UniProt symbol Q9HCE7) in PMID:22020285 (inferred from mutant phenotype).
is_a: GO:0010506 ! regulation of autophagy
is_a: GO:1903335 ! regulation of vacuolar transport
is_a: GO:1903533 ! regulation of protein targeting
is_a: GO:1903649 ! regulation of cytoplasmic transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071211 ! protein targeting to vacuole involved in autophagy
relationship: regulates GO:0071211 ! protein targeting to vacuole involved in autophagy
created_by: pad
creation_date: 2015-03-17T13:54:16Z

[Term]
id: GO:1904052
name: negative regulation of protein targeting to vacuole involved in autophagy
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein targeting to vacuole involved in autophagy." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22020285]
comment: An example of this is SMURF1 in human (UniProt symbol Q9HCE7) in PMID:22020285 (inferred from mutant phenotype).
synonym: "down regulation of protein targeting to vacuole involved in autophagy" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein targeting to vacuole involved in autophagy" EXACT [GOC:TermGenie]
synonym: "downregulation of protein targeting to vacuole involved in autophagy" EXACT [GOC:TermGenie]
synonym: "inhibition of protein targeting to vacuole involved in autophagy" NARROW [GOC:TermGenie]
is_a: GO:0010507 ! negative regulation of autophagy
is_a: GO:0090317 ! negative regulation of intracellular protein transport
is_a: GO:1903336 ! negative regulation of vacuolar transport
is_a: GO:1903650 ! negative regulation of cytoplasmic transport
is_a: GO:1904051 ! regulation of protein targeting to vacuole involved in autophagy
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071211 ! protein targeting to vacuole involved in autophagy
relationship: negatively_regulates GO:0071211 ! protein targeting to vacuole involved in autophagy
created_by: pad
creation_date: 2015-03-17T13:54:22Z

[Term]
id: GO:1904053
name: positive regulation of protein targeting to vacuole involved in autophagy
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein targeting to vacuole involved in autophagy." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22020285]
comment: An example of this is SMURF1 in human (UniProt symbol Q9HCE7) in PMID:22020285 (inferred from mutant phenotype).
synonym: "activation of protein targeting to vacuole involved in autophagy" NARROW [GOC:TermGenie]
synonym: "up regulation of protein targeting to vacuole involved in autophagy" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein targeting to vacuole involved in autophagy" EXACT [GOC:TermGenie]
synonym: "upregulation of protein targeting to vacuole involved in autophagy" EXACT [GOC:TermGenie]
is_a: GO:0010508 ! positive regulation of autophagy
is_a: GO:0090316 ! positive regulation of intracellular protein transport
is_a: GO:1903337 ! positive regulation of vacuolar transport
is_a: GO:1903651 ! positive regulation of cytoplasmic transport
is_a: GO:1904051 ! regulation of protein targeting to vacuole involved in autophagy
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071211 ! protein targeting to vacuole involved in autophagy
relationship: positively_regulates GO:0071211 ! protein targeting to vacuole involved in autophagy
created_by: pad
creation_date: 2015-03-17T13:54:27Z

[Term]
id: GO:1904054
name: regulation of cholangiocyte proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cholangiocyte proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24434010]
synonym: "regulation of hepatoblast proliferation" EXACT [GOC:TermGenie]
is_a: GO:0050678 ! regulation of epithelial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990705 ! cholangiocyte proliferation
relationship: regulates GO:1990705 ! cholangiocyte proliferation
created_by: sl
creation_date: 2015-03-18T17:56:14Z

[Term]
id: GO:1904055
name: negative regulation of cholangiocyte proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cholangiocyte proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24434010]
synonym: "down regulation of cholangiocyte proliferation" EXACT [GOC:TermGenie]
synonym: "down regulation of hepatoblast proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of cholangiocyte proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of hepatoblast proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of cholangiocyte proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of hepatoblast proliferation" EXACT [GOC:TermGenie]
synonym: "inhibition of cholangiocyte proliferation" NARROW [GOC:TermGenie]
synonym: "inhibition of hepatoblast proliferation" NARROW [GOC:TermGenie]
synonym: "negative regulation of hepatoblast proliferation" EXACT [GOC:TermGenie]
is_a: GO:0050680 ! negative regulation of epithelial cell proliferation
is_a: GO:1904054 ! regulation of cholangiocyte proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990705 ! cholangiocyte proliferation
relationship: negatively_regulates GO:1990705 ! cholangiocyte proliferation
created_by: sl
creation_date: 2015-03-18T17:56:20Z

[Term]
id: GO:1904056
name: positive regulation of cholangiocyte proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cholangiocyte proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24434010]
synonym: "activation of cholangiocyte proliferation" NARROW [GOC:TermGenie]
synonym: "activation of hepatoblast proliferation" NARROW [GOC:TermGenie]
synonym: "positive regulation of hepatoblast proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of cholangiocyte proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of hepatoblast proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of cholangiocyte proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of hepatoblast proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of cholangiocyte proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of hepatoblast proliferation" EXACT [GOC:TermGenie]
is_a: GO:0050679 ! positive regulation of epithelial cell proliferation
is_a: GO:1904054 ! regulation of cholangiocyte proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990705 ! cholangiocyte proliferation
relationship: positively_regulates GO:1990705 ! cholangiocyte proliferation
created_by: sl
creation_date: 2015-03-18T17:56:26Z

[Term]
id: GO:1904057
name: negative regulation of sensory perception of pain
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sensory perception of pain." [GO_REF:0000058, GOC:TermGenie, PMID:17167094]
synonym: "down regulation of nociception" EXACT [GOC:TermGenie]
synonym: "down regulation of perception of physiological pain" NARROW [GOC:TermGenie]
synonym: "down regulation of sensory perception of pain" EXACT [GOC:TermGenie]
synonym: "down-regulation of nociception" EXACT [GOC:TermGenie]
synonym: "down-regulation of perception of physiological pain" NARROW [GOC:TermGenie]
synonym: "down-regulation of sensory perception of pain" EXACT [GOC:TermGenie]
synonym: "downregulation of nociception" EXACT [GOC:TermGenie]
synonym: "downregulation of perception of physiological pain" NARROW [GOC:TermGenie]
synonym: "downregulation of sensory perception of pain" EXACT [GOC:TermGenie]
synonym: "inhibition of nociception" NARROW [GOC:TermGenie]
synonym: "inhibition of perception of physiological pain" NARROW [GOC:TermGenie]
synonym: "inhibition of sensory perception of pain" NARROW [GOC:TermGenie]
synonym: "negative regulation of nociception" EXACT [GOC:TermGenie]
synonym: "negative regulation of perception of physiological pain" NARROW [GOC:TermGenie]
is_a: GO:0031645 ! negative regulation of neurological system process
is_a: GO:0051930 ! regulation of sensory perception of pain
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019233 ! sensory perception of pain
relationship: negatively_regulates GO:0019233 ! sensory perception of pain
created_by: sl
creation_date: 2015-03-18T20:33:57Z

[Term]
id: GO:1904058
name: positive regulation of sensory perception of pain
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sensory perception of pain." [GO_REF:0000058, GOC:TermGenie, PMID:17167094]
synonym: "activation of nociception" NARROW [GOC:TermGenie]
synonym: "activation of perception of physiological pain" NARROW [GOC:TermGenie]
synonym: "activation of sensory perception of pain" NARROW [GOC:TermGenie]
synonym: "positive regulation of nociception" EXACT [GOC:TermGenie]
synonym: "positive regulation of perception of physiological pain" NARROW [GOC:TermGenie]
synonym: "up regulation of nociception" EXACT [GOC:TermGenie]
synonym: "up regulation of perception of physiological pain" NARROW [GOC:TermGenie]
synonym: "up regulation of sensory perception of pain" EXACT [GOC:TermGenie]
synonym: "up-regulation of nociception" EXACT [GOC:TermGenie]
synonym: "up-regulation of perception of physiological pain" NARROW [GOC:TermGenie]
synonym: "up-regulation of sensory perception of pain" EXACT [GOC:TermGenie]
synonym: "upregulation of nociception" EXACT [GOC:TermGenie]
synonym: "upregulation of perception of physiological pain" NARROW [GOC:TermGenie]
synonym: "upregulation of sensory perception of pain" EXACT [GOC:TermGenie]
is_a: GO:0031646 ! positive regulation of neurological system process
is_a: GO:0051930 ! regulation of sensory perception of pain
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0019233 ! sensory perception of pain
relationship: positively_regulates GO:0019233 ! sensory perception of pain
created_by: sl
creation_date: 2015-03-18T20:34:03Z

[Term]
id: GO:1904059
name: regulation of locomotor rhythm
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of locomotor rhythm." [GO_REF:0000058, GOC:TermGenie, PMID:16310969]
synonym: "regulation of circadian locomotor activity rhythm" NARROW [GOC:TermGenie]
is_a: GO:0042752 ! regulation of circadian rhythm
is_a: GO:0050795 ! regulation of behavior
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045475 ! locomotor rhythm
relationship: regulates GO:0045475 ! locomotor rhythm
created_by: sl
creation_date: 2015-03-18T20:38:52Z

[Term]
id: GO:1904060
name: negative regulation of locomotor rhythm
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of locomotor rhythm." [GO_REF:0000058, GOC:TermGenie, PMID:16310969]
synonym: "down regulation of circadian locomotor activity rhythm" NARROW [GOC:TermGenie]
synonym: "down regulation of locomotor rhythm" EXACT [GOC:TermGenie]
synonym: "down-regulation of circadian locomotor activity rhythm" NARROW [GOC:TermGenie]
synonym: "down-regulation of locomotor rhythm" EXACT [GOC:TermGenie]
synonym: "downregulation of circadian locomotor activity rhythm" NARROW [GOC:TermGenie]
synonym: "downregulation of locomotor rhythm" EXACT [GOC:TermGenie]
synonym: "inhibition of circadian locomotor activity rhythm" NARROW [GOC:TermGenie]
synonym: "inhibition of locomotor rhythm" NARROW [GOC:TermGenie]
synonym: "negative regulation of circadian locomotor activity rhythm" NARROW [GOC:TermGenie]
is_a: GO:0042754 ! negative regulation of circadian rhythm
is_a: GO:0048521 ! negative regulation of behavior
is_a: GO:1904059 ! regulation of locomotor rhythm
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045475 ! locomotor rhythm
relationship: negatively_regulates GO:0045475 ! locomotor rhythm
created_by: sl
creation_date: 2015-03-18T20:38:58Z

[Term]
id: GO:1904061
name: positive regulation of locomotor rhythm
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of locomotor rhythm." [GO_REF:0000058, GOC:TermGenie, PMID:16310969]
synonym: "activation of circadian locomotor activity rhythm" NARROW [GOC:TermGenie]
synonym: "activation of locomotor rhythm" NARROW [GOC:TermGenie]
synonym: "positive regulation of circadian locomotor activity rhythm" NARROW [GOC:TermGenie]
synonym: "up regulation of circadian locomotor activity rhythm" NARROW [GOC:TermGenie]
synonym: "up regulation of locomotor rhythm" EXACT [GOC:TermGenie]
synonym: "up-regulation of circadian locomotor activity rhythm" NARROW [GOC:TermGenie]
synonym: "up-regulation of locomotor rhythm" EXACT [GOC:TermGenie]
synonym: "upregulation of circadian locomotor activity rhythm" NARROW [GOC:TermGenie]
synonym: "upregulation of locomotor rhythm" EXACT [GOC:TermGenie]
is_a: GO:0042753 ! positive regulation of circadian rhythm
is_a: GO:0048520 ! positive regulation of behavior
is_a: GO:1904059 ! regulation of locomotor rhythm
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045475 ! locomotor rhythm
relationship: positively_regulates GO:0045475 ! locomotor rhythm
created_by: sl
creation_date: 2015-03-18T20:39:03Z

[Term]
id: GO:1904062
name: regulation of cation transmembrane transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cation transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:15304482]
is_a: GO:0034765 ! regulation of ion transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0098655 ! cation transmembrane transport
relationship: regulates GO:0098655 ! cation transmembrane transport
created_by: sl
creation_date: 2015-03-18T21:11:43Z

[Term]
id: GO:1904063
name: negative regulation of cation transmembrane transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cation transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:15304482]
synonym: "down regulation of cation transmembrane transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of cation transmembrane transport" EXACT [GOC:TermGenie]
synonym: "downregulation of cation transmembrane transport" EXACT [GOC:TermGenie]
synonym: "inhibition of cation transmembrane transport" NARROW [GOC:TermGenie]
is_a: GO:0034766 ! negative regulation of ion transmembrane transport
is_a: GO:1904062 ! regulation of cation transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0098655 ! cation transmembrane transport
relationship: negatively_regulates GO:0098655 ! cation transmembrane transport
created_by: sl
creation_date: 2015-03-18T21:11:50Z

[Term]
id: GO:1904064
name: positive regulation of cation transmembrane transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cation transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:15304482]
synonym: "activation of cation transmembrane transport" NARROW [GOC:TermGenie]
synonym: "up regulation of cation transmembrane transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of cation transmembrane transport" EXACT [GOC:TermGenie]
synonym: "upregulation of cation transmembrane transport" EXACT [GOC:TermGenie]
is_a: GO:0034767 ! positive regulation of ion transmembrane transport
is_a: GO:1904062 ! regulation of cation transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0098655 ! cation transmembrane transport
relationship: positively_regulates GO:0098655 ! cation transmembrane transport
created_by: sl
creation_date: 2015-03-18T21:11:55Z

[Term]
id: GO:1904065
name: G-protein coupled acetylcholine receptor signaling pathway involved in positive regulation of acetylcholine secretion, neurotransmission
namespace: biological_process
def: "Any G-protein coupled acetylcholine receptor signaling pathway that is involved in positive regulation of acetylcholine secretion, neurotransmission." [GO_REF:0000060, GOC:kmv, GOC:TermGenie, pmid:22588719]
synonym: "acetylcholine receptor signalling, muscarinic pathway involved in activation of acetylcholine secretion" NARROW [GOC:TermGenie]
synonym: "acetylcholine receptor signalling, muscarinic pathway involved in positive regulation of acetylcholine secretion, neurotransmission" EXACT [GOC:TermGenie]
synonym: "acetylcholine receptor signalling, muscarinic pathway involved in stimulation of acetylcholine secretion" NARROW [GOC:TermGenie]
synonym: "acetylcholine receptor signalling, muscarinic pathway involved in up regulation of acetylcholine secretion" EXACT [GOC:TermGenie]
synonym: "acetylcholine receptor signalling, muscarinic pathway involved in up-regulation of acetylcholine secretion" EXACT [GOC:TermGenie]
synonym: "acetylcholine receptor signalling, muscarinic pathway involved in upregulation of acetylcholine secretion" EXACT [GOC:TermGenie]
synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in activation of acetylcholine secretion" NARROW [GOC:TermGenie]
synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in stimulation of acetylcholine secretion" NARROW [GOC:TermGenie]
synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in up regulation of acetylcholine secretion" EXACT [GOC:TermGenie]
synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in up-regulation of acetylcholine secretion" EXACT [GOC:TermGenie]
synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in upregulation of acetylcholine secretion" EXACT [GOC:TermGenie]
synonym: "muscarinic acetylcholine receptor signaling pathway involved in activation of acetylcholine secretion" NARROW [GOC:TermGenie]
synonym: "muscarinic acetylcholine receptor signaling pathway involved in positive regulation of acetylcholine secretion, neurotransmission" EXACT [GOC:TermGenie]
synonym: "muscarinic acetylcholine receptor signaling pathway involved in stimulation of acetylcholine secretion" NARROW [GOC:TermGenie]
synonym: "muscarinic acetylcholine receptor signaling pathway involved in up regulation of acetylcholine secretion" EXACT [GOC:TermGenie]
synonym: "muscarinic acetylcholine receptor signaling pathway involved in up-regulation of acetylcholine secretion" EXACT [GOC:TermGenie]
synonym: "muscarinic acetylcholine receptor signaling pathway involved in upregulation of acetylcholine secretion" EXACT [GOC:TermGenie]
is_a: GO:0007213 ! G-protein coupled acetylcholine receptor signaling pathway
intersection_of: GO:0007213 ! G-protein coupled acetylcholine receptor signaling pathway
intersection_of: part_of GO:0014057 ! positive regulation of acetylcholine secretion, neurotransmission
relationship: part_of GO:0014057 ! positive regulation of acetylcholine secretion, neurotransmission
created_by: kmv
creation_date: 2015-03-19T15:28:47Z

[Term]
id: GO:1904066
name: G-protein coupled receptor signaling pathway involved in dauer larval development
namespace: biological_process
def: "Any G-protein coupled receptor signaling pathway that is involved in dauer larval development." [GO_REF:0000060, GOC:kmv, GOC:TermGenie, pmid:22665789]
synonym: "G protein coupled receptor protein signaling pathway involved in dauer larval development" EXACT [GOC:TermGenie]
synonym: "G protein coupled receptor protein signalling pathway involved in dauer larval development" EXACT [GOC:TermGenie]
synonym: "G-protein coupled receptor protein signal transduction involved in dauer larval development" EXACT [GOC:TermGenie]
synonym: "G-protein coupled receptor protein signaling pathway involved in dauer larval development" EXACT [GOC:TermGenie]
synonym: "G-protein coupled receptor signalling pathway involved in dauer larval development" EXACT [GOC:TermGenie]
synonym: "G-protein-coupled receptor protein signaling pathway involved in dauer larval development" EXACT [GOC:TermGenie]
synonym: "G-protein-coupled receptor protein signalling pathway involved in dauer larval development" EXACT [GOC:TermGenie]
synonym: "GPCR signaling pathway involved in dauer larval development" EXACT [GOC:TermGenie]
synonym: "GPCR signalling pathway involved in dauer larval development" EXACT [GOC:TermGenie]
is_a: GO:0007186 ! G-protein coupled receptor signaling pathway
intersection_of: GO:0007186 ! G-protein coupled receptor signaling pathway
intersection_of: part_of GO:0040024 ! dauer larval development
relationship: part_of GO:0040024 ! dauer larval development
created_by: kmv
creation_date: 2015-03-20T00:51:06Z

[Term]
id: GO:1904067
name: ascr#2 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with ascr#2." [GO_REF:0000067, GOC:kmv, GOC:TermGenie, PMID:22665789]
is_a: GO:0097367 ! carbohydrate derivative binding
created_by: kmv
creation_date: 2015-03-20T01:39:04Z

[Term]
id: GO:1904068
name: G-protein coupled receptor signaling pathway involved in social behavior
namespace: biological_process
def: "Any G-protein coupled receptor signaling pathway that is involved in social behavior." [GO_REF:0000060, GOC:kmv, GOC:TermGenie, pmid:22665789]
synonym: "G protein coupled receptor protein signaling pathway involved in cooperative behavior" RELATED [GOC:TermGenie]
synonym: "G protein coupled receptor protein signaling pathway involved in social behavior" EXACT [GOC:TermGenie]
synonym: "G protein coupled receptor protein signaling pathway involved in social behaviour" EXACT [GOC:TermGenie]
synonym: "G protein coupled receptor protein signalling pathway involved in cooperative behavior" RELATED [GOC:TermGenie]
synonym: "G protein coupled receptor protein signalling pathway involved in social behavior" EXACT [GOC:TermGenie]
synonym: "G protein coupled receptor protein signalling pathway involved in social behaviour" EXACT [GOC:TermGenie]
synonym: "G-protein coupled receptor protein signal transduction involved in cooperative behavior" RELATED [GOC:TermGenie]
synonym: "G-protein coupled receptor protein signal transduction involved in social behavior" EXACT [GOC:TermGenie]
synonym: "G-protein coupled receptor protein signal transduction involved in social behaviour" EXACT [GOC:TermGenie]
synonym: "G-protein coupled receptor protein signaling pathway involved in cooperative behavior" RELATED [GOC:TermGenie]
synonym: "G-protein coupled receptor protein signaling pathway involved in social behavior" EXACT [GOC:TermGenie]
synonym: "G-protein coupled receptor protein signaling pathway involved in social behaviour" EXACT [GOC:TermGenie]
synonym: "G-protein coupled receptor signaling pathway involved in cooperative behavior" RELATED [GOC:TermGenie]
synonym: "G-protein coupled receptor signaling pathway involved in social behaviour" EXACT [GOC:TermGenie]
synonym: "G-protein coupled receptor signalling pathway involved in cooperative behavior" RELATED [GOC:TermGenie]
synonym: "G-protein coupled receptor signalling pathway involved in social behavior" EXACT [GOC:TermGenie]
synonym: "G-protein coupled receptor signalling pathway involved in social behaviour" EXACT [GOC:TermGenie]
synonym: "G-protein-coupled receptor protein signaling pathway involved in cooperative behavior" RELATED [GOC:TermGenie]
synonym: "G-protein-coupled receptor protein signaling pathway involved in social behavior" EXACT [GOC:TermGenie]
synonym: "G-protein-coupled receptor protein signaling pathway involved in social behaviour" EXACT [GOC:TermGenie]
synonym: "G-protein-coupled receptor protein signalling pathway involved in cooperative behavior" RELATED [GOC:TermGenie]
synonym: "G-protein-coupled receptor protein signalling pathway involved in social behavior" EXACT [GOC:TermGenie]
synonym: "G-protein-coupled receptor protein signalling pathway involved in social behaviour" EXACT [GOC:TermGenie]
synonym: "GPCR signaling pathway involved in cooperative behavior" RELATED [GOC:TermGenie]
synonym: "GPCR signaling pathway involved in social behavior" EXACT [GOC:TermGenie]
synonym: "GPCR signaling pathway involved in social behaviour" EXACT [GOC:TermGenie]
synonym: "GPCR signalling pathway involved in cooperative behavior" RELATED [GOC:TermGenie]
synonym: "GPCR signalling pathway involved in social behavior" EXACT [GOC:TermGenie]
synonym: "GPCR signalling pathway involved in social behaviour" EXACT [GOC:TermGenie]
is_a: GO:0007186 ! G-protein coupled receptor signaling pathway
intersection_of: GO:0007186 ! G-protein coupled receptor signaling pathway
intersection_of: part_of GO:0035176 ! social behavior
relationship: part_of GO:0035176 ! social behavior
created_by: kmv
creation_date: 2015-03-20T01:51:10Z

[Term]
id: GO:1904069
name: ascaroside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ascaroside." [GO_REF:0000068, GOC:kmv, GOC:TermGenie, pmid:25775534]
synonym: "ascaroside metabolism" EXACT [GOC:TermGenie]
is_a: GO:0016137 ! glycoside metabolic process
created_by: kmv
creation_date: 2015-03-20T02:40:14Z

[Term]
id: GO:1904070
name: ascaroside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ascaroside." [GO_REF:0000068, GOC:kmv, GOC:TermGenie, pmid:25775534]
synonym: "ascaroside anabolism" EXACT [GOC:TermGenie]
synonym: "ascaroside biosynthesis" EXACT [GOC:TermGenie]
synonym: "ascaroside formation" EXACT [GOC:TermGenie]
synonym: "ascaroside synthesis" EXACT [GOC:TermGenie]
is_a: GO:0016138 ! glycoside biosynthetic process
is_a: GO:1904069 ! ascaroside metabolic process
created_by: kmv
creation_date: 2015-03-20T02:40:20Z

[Term]
id: GO:1904071
name: presynaptic active zone assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a presynaptic active zone." [GO_REF:0000079, GOC:pr, GOC:TermGenie, PMID:10769383]
synonym: "pre-synaptic active zone assembly" EXACT [GOC:TermGenie]
synonym: "pre-synaptic active zone component assembly" NARROW [GOC:TermGenie]
synonym: "pre-synaptic active zone component formation" NARROW [GOC:TermGenie]
synonym: "pre-synaptic active zone formation" EXACT [GOC:TermGenie]
synonym: "presynaptic active zone formation" EXACT [GOC:TermGenie]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:1990709 ! presynaptic active zone organization
created_by: pr
creation_date: 2015-03-20T10:36:27Z

[Term]
id: GO:1904072
name: presynaptic active zone disassembly
namespace: biological_process
def: "The disaggregation of a presynaptic active zone into its constituent components." [GO_REF:0000079, GOC:pr, GOC:TermGenie, ISBN:9780387325606]
synonym: "pre-synaptic active zone component disassembly" NARROW [GOC:TermGenie]
synonym: "pre-synaptic active zone disassembly" EXACT [GOC:TermGenie]
is_a: GO:0022411 ! cellular component disassembly
is_a: GO:1990709 ! presynaptic active zone organization
created_by: pr
creation_date: 2015-03-20T10:36:33Z

[Term]
id: GO:1904073
name: regulation of trophectodermal cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of trophectodermal cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24508636]
synonym: "regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0042127 ! regulation of cell proliferation
is_a: GO:0045995 ! regulation of embryonic development
is_a: GO:0048638 ! regulation of developmental growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001834 ! trophectodermal cell proliferation
relationship: regulates GO:0001834 ! trophectodermal cell proliferation
created_by: tb
creation_date: 2015-03-20T16:55:56Z

[Term]
id: GO:1904074
name: negative regulation of trophectodermal cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of trophectodermal cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24508636]
synonym: "down regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie]
synonym: "down regulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie]
synonym: "inhibition of trophectoderm cell proliferation" NARROW [GOC:TermGenie]
synonym: "inhibition of trophectodermal cell proliferation" NARROW [GOC:TermGenie]
synonym: "negative regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0008285 ! negative regulation of cell proliferation
is_a: GO:0045992 ! negative regulation of embryonic development
is_a: GO:0048640 ! negative regulation of developmental growth
is_a: GO:1904073 ! regulation of trophectodermal cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001834 ! trophectodermal cell proliferation
relationship: negatively_regulates GO:0001834 ! trophectodermal cell proliferation
created_by: tb
creation_date: 2015-03-20T16:56:02Z

[Term]
id: GO:1904075
name: positive regulation of trophectodermal cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of trophectodermal cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24508636]
synonym: "activation of trophectoderm cell proliferation" NARROW [GOC:TermGenie]
synonym: "activation of trophectodermal cell proliferation" NARROW [GOC:TermGenie]
synonym: "positive regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0008284 ! positive regulation of cell proliferation
is_a: GO:0040019 ! positive regulation of embryonic development
is_a: GO:0048639 ! positive regulation of developmental growth
is_a: GO:1904073 ! regulation of trophectodermal cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001834 ! trophectodermal cell proliferation
relationship: positively_regulates GO:0001834 ! trophectodermal cell proliferation
created_by: tb
creation_date: 2015-03-20T16:56:08Z

[Term]
id: GO:1904076
name: regulation of estrogen biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of estrogen biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:24530842]
synonym: "regulation of estrogen anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of estrogen biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of estrogen formation" EXACT [GOC:TermGenie]
synonym: "regulation of estrogen synthesis" EXACT [GOC:TermGenie]
synonym: "regulation of oestrogen biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of oestrogen biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0046885 ! regulation of hormone biosynthetic process
is_a: GO:0050810 ! regulation of steroid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006703 ! estrogen biosynthetic process
relationship: regulates GO:0006703 ! estrogen biosynthetic process
created_by: tb
creation_date: 2015-03-20T16:56:14Z

[Term]
id: GO:1904077
name: negative regulation of estrogen biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of estrogen biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:24530842]
synonym: "down regulation of estrogen anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of estrogen biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of estrogen biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of estrogen formation" EXACT [GOC:TermGenie]
synonym: "down regulation of estrogen synthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of oestrogen biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of oestrogen biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of estrogen anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of estrogen biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of estrogen biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of estrogen formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of estrogen synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of oestrogen biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of oestrogen biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of estrogen anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of estrogen biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of estrogen biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of estrogen formation" EXACT [GOC:TermGenie]
synonym: "downregulation of estrogen synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of oestrogen biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of oestrogen biosynthetic process" EXACT [GOC:TermGenie]
synonym: "inhibition of estrogen anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of estrogen biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of estrogen biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of estrogen formation" NARROW [GOC:TermGenie]
synonym: "inhibition of estrogen synthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of oestrogen biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of oestrogen biosynthetic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of estrogen anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of estrogen biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of estrogen formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of estrogen synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of oestrogen biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of oestrogen biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0010894 ! negative regulation of steroid biosynthetic process
is_a: GO:0032353 ! negative regulation of hormone biosynthetic process
is_a: GO:1904076 ! regulation of estrogen biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006703 ! estrogen biosynthetic process
relationship: negatively_regulates GO:0006703 ! estrogen biosynthetic process
created_by: tb
creation_date: 2015-03-20T16:56:20Z

[Term]
id: GO:1904078
name: positive regulation of estrogen biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of estrogen biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:24530842]
synonym: "activation of estrogen anabolism" NARROW [GOC:TermGenie]
synonym: "activation of estrogen biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of estrogen biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of estrogen formation" NARROW [GOC:TermGenie]
synonym: "activation of estrogen synthesis" NARROW [GOC:TermGenie]
synonym: "activation of oestrogen biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of oestrogen biosynthetic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of estrogen anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of estrogen biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of estrogen formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of estrogen synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of oestrogen biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of oestrogen biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of estrogen anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of estrogen biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of estrogen biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of estrogen formation" EXACT [GOC:TermGenie]
synonym: "up regulation of estrogen synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of oestrogen biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of oestrogen biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of estrogen anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of estrogen biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of estrogen biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of estrogen formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of estrogen synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of oestrogen biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of oestrogen biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of estrogen anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of estrogen biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of estrogen biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of estrogen formation" EXACT [GOC:TermGenie]
synonym: "upregulation of estrogen synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of oestrogen biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of oestrogen biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0010893 ! positive regulation of steroid biosynthetic process
is_a: GO:0046886 ! positive regulation of hormone biosynthetic process
is_a: GO:1904076 ! regulation of estrogen biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006703 ! estrogen biosynthetic process
relationship: positively_regulates GO:0006703 ! estrogen biosynthetic process
created_by: tb
creation_date: 2015-03-20T16:56:26Z

[Term]
id: GO:1904079
name: obsolete negative regulation of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process
namespace: biological_process
def: "OBSOLETE. Any negative regulation of transcription from RNA polymerase II promoter that is involved in negative regulation of neuron apoptotic process." [GO_REF:0000060, GOC:kmv, GOC:TermGenie, PMID:20150917]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "down regulation of global transcription from RNA polymerase II promoter involved in down regulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "down regulation of global transcription from RNA polymerase II promoter involved in down-regulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "down regulation of global transcription from RNA polymerase II promoter involved in downregulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "down regulation of global transcription from RNA polymerase II promoter involved in inhibition of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "down regulation of global transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "down regulation of global transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process" RELATED [GOC:TermGenie]
synonym: "down regulation of global transcription from RNA polymerase II promoter involved in negative regulation of programmed cell death, neurons" RELATED [GOC:TermGenie]
synonym: "down regulation of global transcription from RNA polymerase II promoter involved in neuron survival" RELATED [GOC:TermGenie]
synonym: "down regulation of transcription from RNA polymerase II promoter involved in down regulation of neuron apoptosis" EXACT [GOC:TermGenie]
synonym: "down regulation of transcription from RNA polymerase II promoter involved in down-regulation of neuron apoptosis" EXACT [GOC:TermGenie]
synonym: "down regulation of transcription from RNA polymerase II promoter involved in downregulation of neuron apoptosis" EXACT [GOC:TermGenie]
synonym: "down regulation of transcription from RNA polymerase II promoter involved in inhibition of neuron apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process" EXACT [GOC:TermGenie]
synonym: "down regulation of transcription from RNA polymerase II promoter involved in negative regulation of programmed cell death, neurons" EXACT [GOC:TermGenie]
synonym: "down regulation of transcription from RNA polymerase II promoter involved in neuron survival" NARROW [GOC:TermGenie]
synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in down regulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in down-regulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in downregulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in inhibition of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process" RELATED [GOC:TermGenie]
synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in negative regulation of programmed cell death, neurons" RELATED [GOC:TermGenie]
synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in neuron survival" RELATED [GOC:TermGenie]
synonym: "down-regulation of transcription from RNA polymerase II promoter involved in down regulation of neuron apoptosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of transcription from RNA polymerase II promoter involved in down-regulation of neuron apoptosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of transcription from RNA polymerase II promoter involved in downregulation of neuron apoptosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of transcription from RNA polymerase II promoter involved in inhibition of neuron apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of transcription from RNA polymerase II promoter involved in negative regulation of programmed cell death, neurons" EXACT [GOC:TermGenie]
synonym: "down-regulation of transcription from RNA polymerase II promoter involved in neuron survival" NARROW [GOC:TermGenie]
synonym: "downregulation of global transcription from RNA polymerase II promoter involved in down regulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "downregulation of global transcription from RNA polymerase II promoter involved in down-regulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "downregulation of global transcription from RNA polymerase II promoter involved in downregulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "downregulation of global transcription from RNA polymerase II promoter involved in inhibition of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "downregulation of global transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "downregulation of global transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process" RELATED [GOC:TermGenie]
synonym: "downregulation of global transcription from RNA polymerase II promoter involved in negative regulation of programmed cell death, neurons" RELATED [GOC:TermGenie]
synonym: "downregulation of global transcription from RNA polymerase II promoter involved in neuron survival" RELATED [GOC:TermGenie]
synonym: "downregulation of transcription from RNA polymerase II promoter involved in down regulation of neuron apoptosis" EXACT [GOC:TermGenie]
synonym: "downregulation of transcription from RNA polymerase II promoter involved in down-regulation of neuron apoptosis" EXACT [GOC:TermGenie]
synonym: "downregulation of transcription from RNA polymerase II promoter involved in downregulation of neuron apoptosis" EXACT [GOC:TermGenie]
synonym: "downregulation of transcription from RNA polymerase II promoter involved in inhibition of neuron apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of transcription from RNA polymerase II promoter involved in negative regulation of programmed cell death, neurons" EXACT [GOC:TermGenie]
synonym: "downregulation of transcription from RNA polymerase II promoter involved in neuron survival" NARROW [GOC:TermGenie]
synonym: "inhibition of global transcription from RNA polymerase II promoter involved in down regulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "inhibition of global transcription from RNA polymerase II promoter involved in down-regulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "inhibition of global transcription from RNA polymerase II promoter involved in downregulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "inhibition of global transcription from RNA polymerase II promoter involved in inhibition of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "inhibition of global transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "inhibition of global transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process" RELATED [GOC:TermGenie]
synonym: "inhibition of global transcription from RNA polymerase II promoter involved in negative regulation of programmed cell death, neurons" RELATED [GOC:TermGenie]
synonym: "inhibition of global transcription from RNA polymerase II promoter involved in neuron survival" RELATED [GOC:TermGenie]
synonym: "inhibition of transcription from RNA polymerase II promoter involved in down regulation of neuron apoptosis" EXACT [GOC:TermGenie]
synonym: "inhibition of transcription from RNA polymerase II promoter involved in down-regulation of neuron apoptosis" EXACT [GOC:TermGenie]
synonym: "inhibition of transcription from RNA polymerase II promoter involved in downregulation of neuron apoptosis" EXACT [GOC:TermGenie]
synonym: "inhibition of transcription from RNA polymerase II promoter involved in inhibition of neuron apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process" EXACT [GOC:TermGenie]
synonym: "inhibition of transcription from RNA polymerase II promoter involved in negative regulation of programmed cell death, neurons" EXACT [GOC:TermGenie]
synonym: "inhibition of transcription from RNA polymerase II promoter involved in neuron survival" NARROW [GOC:TermGenie]
synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in down regulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in down-regulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in downregulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in inhibition of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process" RELATED [GOC:TermGenie]
synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in negative regulation of programmed cell death, neurons" RELATED [GOC:TermGenie]
synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in neuron survival" RELATED [GOC:TermGenie]
synonym: "negative regulation of global transcription from Pol II promoter involved in down regulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "negative regulation of global transcription from Pol II promoter involved in down-regulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "negative regulation of global transcription from Pol II promoter involved in downregulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "negative regulation of global transcription from Pol II promoter involved in inhibition of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "negative regulation of global transcription from Pol II promoter involved in negative regulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "negative regulation of global transcription from Pol II promoter involved in negative regulation of neuron apoptotic process" RELATED [GOC:TermGenie]
synonym: "negative regulation of global transcription from Pol II promoter involved in negative regulation of programmed cell death, neurons" RELATED [GOC:TermGenie]
synonym: "negative regulation of global transcription from Pol II promoter involved in neuron survival" RELATED [GOC:TermGenie]
synonym: "negative regulation of transcription from Pol II promoter involved in down regulation of neuron apoptosis" EXACT [GOC:TermGenie]
synonym: "negative regulation of transcription from Pol II promoter involved in down-regulation of neuron apoptosis" EXACT [GOC:TermGenie]
synonym: "negative regulation of transcription from Pol II promoter involved in downregulation of neuron apoptosis" EXACT [GOC:TermGenie]
synonym: "negative regulation of transcription from Pol II promoter involved in inhibition of neuron apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of transcription from Pol II promoter involved in negative regulation of neuron apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of transcription from Pol II promoter involved in negative regulation of neuron apoptotic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of transcription from Pol II promoter involved in negative regulation of programmed cell death, neurons" EXACT [GOC:TermGenie]
synonym: "negative regulation of transcription from Pol II promoter involved in neuron survival" NARROW [GOC:TermGenie]
synonym: "negative regulation of transcription from RNA polymerase II promoter involved in down regulation of neuron apoptosis" EXACT [GOC:TermGenie]
synonym: "negative regulation of transcription from RNA polymerase II promoter involved in down-regulation of neuron apoptosis" EXACT [GOC:TermGenie]
synonym: "negative regulation of transcription from RNA polymerase II promoter involved in downregulation of neuron apoptosis" EXACT [GOC:TermGenie]
synonym: "negative regulation of transcription from RNA polymerase II promoter involved in inhibition of neuron apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process" EXACT []
synonym: "negative regulation of transcription from RNA polymerase II promoter involved in negative regulation of programmed cell death, neurons" EXACT [GOC:TermGenie]
synonym: "negative regulation of transcription from RNA polymerase II promoter involved in neuron survival" NARROW [GOC:TermGenie]
synonym: "negative regulation of transcription from RNA polymerase II promoter, global involved in down regulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "negative regulation of transcription from RNA polymerase II promoter, global involved in down-regulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "negative regulation of transcription from RNA polymerase II promoter, global involved in downregulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "negative regulation of transcription from RNA polymerase II promoter, global involved in inhibition of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "negative regulation of transcription from RNA polymerase II promoter, global involved in negative regulation of neuron apoptosis" RELATED [GOC:TermGenie]
synonym: "negative regulation of transcription from RNA polymerase II promoter, global involved in negative regulation of neuron apoptotic process" RELATED [GOC:TermGenie]
synonym: "negative regulation of transcription from RNA polymerase II promoter, global involved in negative regulation of programmed cell death, neurons" RELATED [GOC:TermGenie]
synonym: "negative regulation of transcription from RNA polymerase II promoter, global involved in neuron survival" RELATED [GOC:TermGenie]
is_obsolete: true
created_by: kmv
creation_date: 2015-03-24T17:28:41Z

[Term]
id: GO:1904080
name: positive regulation of transcription from RNA polymerase II promoter involved in neuron fate specification
namespace: biological_process
def: "Any positive regulation of transcription from RNA polymerase II promoter that is involved in neuron fate specification." [GO_REF:0000060, GOC:kmv, GOC:TermGenie, PMID:11959845]
synonym: "activation of global transcription from RNA polymerase II promoter involved in neuron fate specification" RELATED [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase II promoter involved in neuron fate specification" EXACT [GOC:TermGenie]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in neuron fate specification" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription from Pol II promoter involved in neuron fate specification" RELATED [GOC:TermGenie]
synonym: "positive regulation of transcription from Pol II promoter involved in neuron fate specification" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription from RNA polymerase II promoter, global involved in neuron fate specification" RELATED [GOC:TermGenie]
synonym: "stimulation of global transcription from RNA polymerase II promoter involved in neuron fate specification" NARROW [GOC:TermGenie]
synonym: "stimulation of transcription from RNA polymerase II promoter involved in neuron fate specification" EXACT [GOC:TermGenie]
synonym: "up regulation of global transcription from RNA polymerase II promoter involved in neuron fate specification" RELATED [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase II promoter involved in neuron fate specification" EXACT [GOC:TermGenie]
synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in neuron fate specification" RELATED [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase II promoter involved in neuron fate specification" EXACT [GOC:TermGenie]
synonym: "upregulation of global transcription from RNA polymerase II promoter involved in neuron fate specification" RELATED [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase II promoter involved in neuron fate specification" EXACT [GOC:TermGenie]
is_a: GO:0060850 ! regulation of transcription involved in cell fate commitment
is_a: GO:1904081 ! positive regulation of transcription from RNA polymerase II promoter involved in neuron differentiation
intersection_of: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
intersection_of: part_of GO:0048665 ! neuron fate specification
relationship: part_of GO:0048665 ! neuron fate specification
created_by: kmv
creation_date: 2015-03-24T18:56:50Z

[Term]
id: GO:1904081
name: positive regulation of transcription from RNA polymerase II promoter involved in neuron differentiation
namespace: biological_process
def: "Any positive regulation of transcription from RNA polymerase II promoter that is involved in neuron differentiation." [GO_REF:0000060, GOC:kmv, GOC:TermGenie, PMID:24353061]
synonym: "activation of global transcription from RNA polymerase II promoter involved in neuron differentiation" RELATED [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase II promoter involved in neuron differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in neuron differentiation" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription from Pol II promoter involved in neuron differentiation" RELATED [GOC:TermGenie]
synonym: "positive regulation of transcription from Pol II promoter involved in neuron differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription from RNA polymerase II promoter, global involved in neuron differentiation" RELATED [GOC:TermGenie]
synonym: "stimulation of global transcription from RNA polymerase II promoter involved in neuron differentiation" NARROW [GOC:TermGenie]
synonym: "stimulation of transcription from RNA polymerase II promoter involved in neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of global transcription from RNA polymerase II promoter involved in neuron differentiation" RELATED [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase II promoter involved in neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in neuron differentiation" RELATED [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase II promoter involved in neuron differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of global transcription from RNA polymerase II promoter involved in neuron differentiation" RELATED [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase II promoter involved in neuron differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
intersection_of: part_of GO:0030182 ! neuron differentiation
relationship: part_of GO:0030182 ! neuron differentiation
created_by: kmv
creation_date: 2015-03-24T20:15:59Z

[Term]
id: GO:1904082
name: pyrimidine nucleobase transmembrane transport
namespace: biological_process
def: "The directed movement of pyrimidine nucleobase across a membrane." [GO_REF:0000069, GOC:TermGenie]
is_a: GO:0015855 ! pyrimidine nucleobase transport
is_a: GO:0072531 ! pyrimidine-containing compound transmembrane transport
created_by: tb
creation_date: 2015-03-25T00:13:16Z

[Term]
id: GO:1904083
name: obsolete regulation of epiboly
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of epiboly." [GO_REF:0000058, GOC:TermGenie, PMID:24892953]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "regulation of epiboly" EXACT []
is_obsolete: true
created_by: dos
creation_date: 2015-03-25T10:53:34Z

[Term]
id: GO:1904084
name: obsolete negative regulation of epiboly
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of epiboly." [GO_REF:0000058, GOC:TermGenie, PMID:24892953]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "down regulation of epiboly" EXACT [GOC:TermGenie]
synonym: "down-regulation of epiboly" EXACT [GOC:TermGenie]
synonym: "downregulation of epiboly" EXACT [GOC:TermGenie]
synonym: "inhibition of epiboly" NARROW [GOC:TermGenie]
synonym: "negative regulation of epiboly" EXACT []
is_obsolete: true
created_by: dos
creation_date: 2015-03-25T10:53:40Z

[Term]
id: GO:1904085
name: obsolete positive regulation of epiboly
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of epiboly." [GO_REF:0000058, GOC:TermGenie, PMID:24892953]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "activation of epiboly" NARROW [GOC:TermGenie]
synonym: "positive regulation of epiboly" EXACT []
synonym: "up regulation of epiboly" EXACT [GOC:TermGenie]
synonym: "up-regulation of epiboly" EXACT [GOC:TermGenie]
synonym: "upregulation of epiboly" EXACT [GOC:TermGenie]
is_obsolete: true
created_by: dos
creation_date: 2015-03-25T10:53:47Z

[Term]
id: GO:1904086
name: regulation of epiboly involved in gastrulation with mouth forming second
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of epiboly involved in gastrulation with mouth forming second." [GO_REF:0000058, GOC:TermGenie, PMID:24892953]
is_a: GO:0010470 ! regulation of gastrulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0055113 ! epiboly involved in gastrulation with mouth forming second
relationship: regulates GO:0055113 ! epiboly involved in gastrulation with mouth forming second
created_by: dos
creation_date: 2015-03-25T11:17:34Z

[Term]
id: GO:1904087
name: negative regulation of epiboly involved in gastrulation with mouth forming second
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of epiboly involved in gastrulation with mouth forming second." [GO_REF:0000058, GOC:TermGenie, PMID:24892953]
synonym: "down regulation of epiboly involved in gastrulation with mouth forming second" EXACT [GOC:TermGenie]
synonym: "down-regulation of epiboly involved in gastrulation with mouth forming second" EXACT [GOC:TermGenie]
synonym: "downregulation of epiboly involved in gastrulation with mouth forming second" EXACT [GOC:TermGenie]
synonym: "inhibition of epiboly involved in gastrulation with mouth forming second" NARROW [GOC:TermGenie]
is_a: GO:1904086 ! regulation of epiboly involved in gastrulation with mouth forming second
is_a: GO:2000542 ! negative regulation of gastrulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0055113 ! epiboly involved in gastrulation with mouth forming second
relationship: negatively_regulates GO:0055113 ! epiboly involved in gastrulation with mouth forming second
created_by: dos
creation_date: 2015-03-25T11:17:41Z

[Term]
id: GO:1904088
name: positive regulation of epiboly involved in gastrulation with mouth forming second
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of epiboly involved in gastrulation with mouth forming second." [GO_REF:0000058, GOC:TermGenie, PMID:24892953]
synonym: "activation of epiboly involved in gastrulation with mouth forming second" NARROW [GOC:TermGenie]
synonym: "up regulation of epiboly involved in gastrulation with mouth forming second" EXACT [GOC:TermGenie]
synonym: "up-regulation of epiboly involved in gastrulation with mouth forming second" EXACT [GOC:TermGenie]
synonym: "upregulation of epiboly involved in gastrulation with mouth forming second" EXACT [GOC:TermGenie]
is_a: GO:1904086 ! regulation of epiboly involved in gastrulation with mouth forming second
is_a: GO:2000543 ! positive regulation of gastrulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0055113 ! epiboly involved in gastrulation with mouth forming second
relationship: positively_regulates GO:0055113 ! epiboly involved in gastrulation with mouth forming second
created_by: dos
creation_date: 2015-03-25T11:17:47Z

[Term]
id: GO:1904089
name: negative regulation of neuron apoptotic process by negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A negative regulation of transcription from RNA polymerase II promoter that results in negative regulation of neuron apoptotic process." [GO_REF:0000063, GOC:kmv, GOC:TermGenie, PMID:20150917]
synonym: "negative regulation of neuron apoptosis by negative regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "negative regulation of programmed cell death, neurons by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
is_a: GO:0043524 ! negative regulation of neuron apoptotic process
intersection_of: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
intersection_of: negatively_regulates GO:0051402 ! neuron apoptotic process
relationship: negatively_regulates GO:0051402 ! neuron apoptotic process
created_by: pr
creation_date: 2015-03-25T21:04:51Z

[Term]
id: GO:1904090
name: peptidase inhibitor complex
namespace: cellular_component
def: "A protein complex which is capable of peptidase inhibitor activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:20860624]
comment: An example of this is Cystatin-A in human (UniProt symbol P01040) in PMID:20860624 (inferred from physical interaction).
synonym: "Cathepsin-B - cystatin-A complex" NARROW []
is_a: GO:0043234 ! protein complex
created_by: bhm
creation_date: 2015-03-26T10:16:27Z

[Term]
id: GO:1904091
name: peptidyl carrier protein activity involved in nonribosomal peptide biosynthesis
namespace: molecular_function
def: "Any oligopeptide binding that is involved in nonribosomal peptide biosynthetic process." [GO_REF:0000061, GOC:pr, GOC:TermGenie, GOC:vw, PMID:17502372]
comment: Examples are the ferrichrome synthetase Sib1 in S. pombe and the peptidyl carrier protein (PCP) module in bacterial nonribosomal peptide synthases (NRPSs), which holds the peptidyl group and acts as a swinging arm, limiting diffusion until the peptide comes into contact with the next enzymatic module in the NRPS process.
synonym: "Oligopeptid binding involved in non-ribosomal peptide biosynthesis" RELATED [GOC:TermGenie]
synonym: "Oligopeptid binding involved in non-ribosomal peptide biosynthetic process" RELATED [GOC:TermGenie]
synonym: "Oligopeptid binding involved in non-ribosomal peptide formation" RELATED [GOC:TermGenie]
synonym: "Oligopeptid binding involved in non-ribosomal peptide synthesis" RELATED [GOC:TermGenie]
synonym: "Oligopeptid binding involved in nonribosomal peptide anabolism" RELATED [GOC:TermGenie]
synonym: "Oligopeptid binding involved in nonribosomal peptide biosynthesis" RELATED [GOC:TermGenie]
synonym: "Oligopeptid binding involved in nonribosomal peptide biosynthetic process" RELATED [GOC:TermGenie]
synonym: "Oligopeptid binding involved in nonribosomal peptide formation" RELATED [GOC:TermGenie]
synonym: "Oligopeptid binding involved in nonribosomal peptide synthesis" RELATED [GOC:TermGenie]
synonym: "Oligopeptid binding involved in nonribosomal peptide synthetase" RELATED [GOC:TermGenie]
synonym: "oligopeptide binding involved in non-ribosomal peptide biosynthesis" EXACT [GOC:TermGenie]
synonym: "oligopeptide binding involved in non-ribosomal peptide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "oligopeptide binding involved in non-ribosomal peptide formation" EXACT [GOC:TermGenie]
synonym: "oligopeptide binding involved in non-ribosomal peptide synthesis" EXACT [GOC:TermGenie]
synonym: "oligopeptide binding involved in nonribosomal peptide anabolism" EXACT [GOC:TermGenie]
synonym: "oligopeptide binding involved in nonribosomal peptide biosynthesis" EXACT [GOC:TermGenie]
synonym: "oligopeptide binding involved in nonribosomal peptide biosynthetic process" EXACT [GOC:pr]
synonym: "oligopeptide binding involved in nonribosomal peptide formation" EXACT [GOC:TermGenie]
synonym: "oligopeptide binding involved in nonribosomal peptide synthesis" EXACT [GOC:TermGenie]
synonym: "oligopeptide binding involved in nonribosomal peptide synthetase" RELATED [GOC:TermGenie]
synonym: "oligopeptides binding involved in non-ribosomal peptide biosynthesis" EXACT [GOC:TermGenie]
synonym: "oligopeptides binding involved in non-ribosomal peptide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "oligopeptides binding involved in non-ribosomal peptide formation" EXACT [GOC:TermGenie]
synonym: "oligopeptides binding involved in non-ribosomal peptide synthesis" EXACT [GOC:TermGenie]
synonym: "oligopeptides binding involved in nonribosomal peptide anabolism" EXACT [GOC:TermGenie]
synonym: "oligopeptides binding involved in nonribosomal peptide biosynthesis" EXACT [GOC:TermGenie]
synonym: "oligopeptides binding involved in nonribosomal peptide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "oligopeptides binding involved in nonribosomal peptide formation" EXACT [GOC:TermGenie]
synonym: "oligopeptides binding involved in nonribosomal peptide synthesis" EXACT [GOC:TermGenie]
synonym: "oligopeptides binding involved in nonribosomal peptide synthetase" RELATED [GOC:TermGenie]
synonym: "oligopeptido binding involved in non-ribosomal peptide biosynthesis" RELATED [GOC:TermGenie]
synonym: "oligopeptido binding involved in non-ribosomal peptide biosynthetic process" RELATED [GOC:TermGenie]
synonym: "oligopeptido binding involved in non-ribosomal peptide formation" RELATED [GOC:TermGenie]
synonym: "oligopeptido binding involved in non-ribosomal peptide synthesis" RELATED [GOC:TermGenie]
synonym: "oligopeptido binding involved in nonribosomal peptide anabolism" RELATED [GOC:TermGenie]
synonym: "oligopeptido binding involved in nonribosomal peptide biosynthesis" RELATED [GOC:TermGenie]
synonym: "oligopeptido binding involved in nonribosomal peptide biosynthetic process" RELATED [GOC:TermGenie]
synonym: "oligopeptido binding involved in nonribosomal peptide formation" RELATED [GOC:TermGenie]
synonym: "oligopeptido binding involved in nonribosomal peptide synthesis" RELATED [GOC:TermGenie]
synonym: "oligopeptido binding involved in nonribosomal peptide synthetase" RELATED [GOC:TermGenie]
synonym: "peptidyl binding involved in nonribosomal peptide biosynthesis" EXACT [GOC:pr]
synonym: "peptidyl binding involved in nonribosomal peptide biosynthetic process" EXACT [GOC:pr]
synonym: "peptidyl carrier protein" RELATED [GOC:pr]
synonym: "peptidyl carrier protein activity involved in nonribosomal peptide biosynthetic process" EXACT [GOC:pr]
is_a: GO:1900750 ! oligopeptide binding
intersection_of: GO:1900750 ! oligopeptide binding
intersection_of: part_of GO:0019184 ! nonribosomal peptide biosynthetic process
relationship: part_of GO:0019184 ! nonribosomal peptide biosynthetic process
created_by: pr
creation_date: 2015-03-26T10:41:52Z

[Term]
id: GO:1904092
name: regulation of autophagic cell death
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of autophagic cell death." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25736836]
synonym: "regulation of autophagic death" BROAD [GOC:TermGenie]
synonym: "regulation of programmed cell death by autophagy" BROAD [GOC:TermGenie]
synonym: "regulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie]
synonym: "regulation of type II programmed cell death" RELATED [GOC:TermGenie]
is_a: GO:0043067 ! regulation of programmed cell death
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048102 ! autophagic cell death
relationship: regulates GO:0048102 ! autophagic cell death
created_by: bhm
creation_date: 2015-03-26T16:41:32Z

[Term]
id: GO:1904093
name: negative regulation of autophagic cell death
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of autophagic cell death." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25736836]
synonym: "down regulation of autophagic cell death" EXACT [GOC:TermGenie]
synonym: "down regulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie]
synonym: "down regulation of type II programmed cell death" RELATED [GOC:TermGenie]
synonym: "down-regulation of autophagic cell death" EXACT [GOC:TermGenie]
synonym: "down-regulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie]
synonym: "down-regulation of type II programmed cell death" RELATED [GOC:TermGenie]
synonym: "downregulation of autophagic cell death" EXACT [GOC:TermGenie]
synonym: "downregulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie]
synonym: "downregulation of type II programmed cell death" RELATED [GOC:TermGenie]
synonym: "inhibition of autophagic cell death" NARROW [GOC:TermGenie]
synonym: "inhibition of programmed cell death by macroautophagy" NARROW [GOC:TermGenie]
synonym: "inhibition of type II programmed cell death" RELATED [GOC:TermGenie]
synonym: "negative regulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie]
synonym: "negative regulation of type II programmed cell death" RELATED [GOC:TermGenie]
is_a: GO:0043069 ! negative regulation of programmed cell death
is_a: GO:1904092 ! regulation of autophagic cell death
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048102 ! autophagic cell death
relationship: negatively_regulates GO:0048102 ! autophagic cell death
created_by: bhm
creation_date: 2015-03-26T16:41:39Z

[Term]
id: GO:1904094
name: positive regulation of autophagic cell death
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of autophagic cell death." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25736836]
synonym: "activation of autophagic cell death" NARROW [GOC:TermGenie]
synonym: "activation of programmed cell death by macroautophagy" NARROW [GOC:TermGenie]
synonym: "activation of type II programmed cell death" RELATED [GOC:TermGenie]
synonym: "positive regulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie]
synonym: "positive regulation of type II programmed cell death" RELATED [GOC:TermGenie]
synonym: "up regulation of autophagic cell death" EXACT [GOC:TermGenie]
synonym: "up regulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie]
synonym: "up regulation of type II programmed cell death" RELATED [GOC:TermGenie]
synonym: "up-regulation of autophagic cell death" EXACT [GOC:TermGenie]
synonym: "up-regulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie]
synonym: "up-regulation of type II programmed cell death" RELATED [GOC:TermGenie]
synonym: "upregulation of autophagic cell death" EXACT [GOC:TermGenie]
synonym: "upregulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie]
synonym: "upregulation of type II programmed cell death" RELATED [GOC:TermGenie]
is_a: GO:0043068 ! positive regulation of programmed cell death
is_a: GO:1904092 ! regulation of autophagic cell death
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048102 ! autophagic cell death
relationship: positively_regulates GO:0048102 ! autophagic cell death
created_by: bhm
creation_date: 2015-03-26T16:41:45Z

[Term]
id: GO:1904095
name: negative regulation of endosperm development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of endosperm development." [GO_REF:0000058, GOC:TermGenie, PMID:25194028]
synonym: "down regulation of endosperm development" EXACT [GOC:TermGenie]
synonym: "down-regulation of endosperm development" EXACT [GOC:TermGenie]
synonym: "downregulation of endosperm development" EXACT [GOC:TermGenie]
synonym: "inhibition of endosperm development" NARROW [GOC:TermGenie]
is_a: GO:0048581 ! negative regulation of post-embryonic development
is_a: GO:2000014 ! regulation of endosperm development
is_a: GO:2000242 ! negative regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009960 ! endosperm development
relationship: negatively_regulates GO:0009960 ! endosperm development
created_by: tb
creation_date: 2015-03-26T22:07:25Z

[Term]
id: GO:1904096
name: protein tyrosine phosphatase complex
namespace: cellular_component
def: "A protein complex which is capable of protein tyrosine phosphatase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:22389722]
comment: An example of this is ACPP in human (UniProt symbol P15309) in PMID:22389722 (inferred from physical interaction).
is_a: GO:1903293 ! phosphatase complex
created_by: bhm
creation_date: 2015-03-27T14:34:59Z

[Term]
id: GO:1904097
name: acid phosphatase complex
namespace: cellular_component
def: "A protein complex which is capable of acid phosphatase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:8132635]
comment: An example of this is ACPP in human (UniProt symbol P15309) in PMID:22389722 (inferred from physical interaction).
is_a: GO:1903293 ! phosphatase complex
created_by: bhm
creation_date: 2015-03-27T14:36:36Z

[Term]
id: GO:1904098
name: regulation of protein O-linked glycosylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein O-linked glycosylation." [GO_REF:0000058, GOC:TermGenie, PMID:24509081]
synonym: "regulation of protein amino acid O-linked glycosylation" EXACT [GOC:TermGenie]
is_a: GO:0060049 ! regulation of protein glycosylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006493 ! protein O-linked glycosylation
relationship: regulates GO:0006493 ! protein O-linked glycosylation
created_by: krc
creation_date: 2015-03-27T16:09:58Z

[Term]
id: GO:1904099
name: negative regulation of protein O-linked glycosylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein O-linked glycosylation." [GO_REF:0000058, GOC:TermGenie, PMID:24509081]
synonym: "down regulation of protein amino acid O-linked glycosylation" EXACT [GOC:TermGenie]
synonym: "down regulation of protein O-linked glycosylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein amino acid O-linked glycosylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein O-linked glycosylation" EXACT [GOC:TermGenie]
synonym: "downregulation of protein amino acid O-linked glycosylation" EXACT [GOC:TermGenie]
synonym: "downregulation of protein O-linked glycosylation" EXACT [GOC:TermGenie]
synonym: "inhibition of protein amino acid O-linked glycosylation" NARROW [GOC:TermGenie]
synonym: "inhibition of protein O-linked glycosylation" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein amino acid O-linked glycosylation" EXACT [GOC:TermGenie]
is_a: GO:0060051 ! negative regulation of protein glycosylation
is_a: GO:1904098 ! regulation of protein O-linked glycosylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006493 ! protein O-linked glycosylation
relationship: negatively_regulates GO:0006493 ! protein O-linked glycosylation
created_by: krc
creation_date: 2015-03-27T16:10:04Z

[Term]
id: GO:1904100
name: positive regulation of protein O-linked glycosylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein O-linked glycosylation." [GO_REF:0000058, GOC:TermGenie, PMID:24509081]
synonym: "activation of protein amino acid O-linked glycosylation" NARROW [GOC:TermGenie]
synonym: "activation of protein O-linked glycosylation" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein amino acid O-linked glycosylation" EXACT [GOC:TermGenie]
synonym: "up regulation of protein amino acid O-linked glycosylation" EXACT [GOC:TermGenie]
synonym: "up regulation of protein O-linked glycosylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein amino acid O-linked glycosylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein O-linked glycosylation" EXACT [GOC:TermGenie]
synonym: "upregulation of protein amino acid O-linked glycosylation" EXACT [GOC:TermGenie]
synonym: "upregulation of protein O-linked glycosylation" EXACT [GOC:TermGenie]
is_a: GO:0060050 ! positive regulation of protein glycosylation
is_a: GO:1904098 ! regulation of protein O-linked glycosylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006493 ! protein O-linked glycosylation
relationship: positively_regulates GO:0006493 ! protein O-linked glycosylation
created_by: krc
creation_date: 2015-03-27T16:10:10Z

[Term]
id: GO:1904101
name: response to acadesine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acadesine stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:20802119]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: mr
creation_date: 2015-03-30T22:36:26Z

[Term]
id: GO:1904102
name: cellular response to acadesine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acadesine stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:20802119]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1904101 ! response to acadesine
created_by: mr
creation_date: 2015-03-30T22:36:32Z

[Term]
id: GO:1904103
name: regulation of convergent extension involved in gastrulation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of convergent extension involved in gastrulation." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953]
is_a: GO:0010470 ! regulation of gastrulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060027 ! convergent extension involved in gastrulation
relationship: regulates GO:0060027 ! convergent extension involved in gastrulation
created_by: dph
creation_date: 2015-04-01T11:17:05Z

[Term]
id: GO:1904104
name: negative regulation of convergent extension involved in gastrulation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of convergent extension involved in gastrulation." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953]
synonym: "down regulation of convergent extension involved in gastrulation" EXACT [GOC:TermGenie]
synonym: "down-regulation of convergent extension involved in gastrulation" EXACT [GOC:TermGenie]
synonym: "downregulation of convergent extension involved in gastrulation" EXACT [GOC:TermGenie]
synonym: "inhibition of convergent extension involved in gastrulation" NARROW [GOC:TermGenie]
is_a: GO:1904103 ! regulation of convergent extension involved in gastrulation
is_a: GO:2000542 ! negative regulation of gastrulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060027 ! convergent extension involved in gastrulation
relationship: negatively_regulates GO:0060027 ! convergent extension involved in gastrulation
created_by: dph
creation_date: 2015-04-01T11:17:12Z

[Term]
id: GO:1904105
name: positive regulation of convergent extension involved in gastrulation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of convergent extension involved in gastrulation." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953]
synonym: "activation of convergent extension involved in gastrulation" NARROW [GOC:TermGenie]
synonym: "up regulation of convergent extension involved in gastrulation" EXACT [GOC:TermGenie]
synonym: "up-regulation of convergent extension involved in gastrulation" EXACT [GOC:TermGenie]
synonym: "upregulation of convergent extension involved in gastrulation" EXACT [GOC:TermGenie]
is_a: GO:1904103 ! regulation of convergent extension involved in gastrulation
is_a: GO:2000543 ! positive regulation of gastrulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060027 ! convergent extension involved in gastrulation
relationship: positively_regulates GO:0060027 ! convergent extension involved in gastrulation
created_by: dph
creation_date: 2015-04-01T11:17:18Z

[Term]
id: GO:1904106
name: protein localization to microvillus
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a microvillus." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:25335890]
synonym: "protein localisation in microvillus" EXACT [GOC:TermGenie]
synonym: "protein localisation to microvillus" EXACT [GOC:TermGenie]
synonym: "protein localization in microvillus" EXACT [GOC:TermGenie]
is_a: GO:0008104 ! protein localization
created_by: kmv
creation_date: 2015-04-01T18:14:41Z

[Term]
id: GO:1904107
name: protein localization to microvillus membrane
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a microvillus membrane." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:25335890]
synonym: "protein localisation in microvillus membrane" EXACT [GOC:TermGenie]
synonym: "protein localisation to microvillus membrane" EXACT [GOC:TermGenie]
synonym: "protein localization in microvillus membrane" EXACT [GOC:TermGenie]
is_a: GO:0072659 ! protein localization to plasma membrane
is_a: GO:1904106 ! protein localization to microvillus
created_by: kmv
creation_date: 2015-04-01T18:14:48Z

[Term]
id: GO:1904108
name: protein localization to ciliary inversin compartment
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a ciliary inversin compartment." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:25335890]
synonym: "protein localisation in ciliary inversin compartment" EXACT [GOC:TermGenie]
synonym: "protein localisation to ciliary inversin compartment" EXACT [GOC:TermGenie]
synonym: "protein localization in ciliary inversin compartment" EXACT [GOC:TermGenie]
is_a: GO:0061512 ! protein localization to cilium
created_by: kmv
creation_date: 2015-04-01T20:54:26Z

[Term]
id: GO:1904109
name: positive regulation of cholesterol import
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cholesterol import." [GO_REF:0000058, GOC:TermGenie, PMID:16772292]
synonym: "activation of cholesterol import" NARROW [GOC:TermGenie]
synonym: "activation of cholesterol uptake" NARROW [GOC:TermGenie]
synonym: "positive regulation of cholesterol uptake" EXACT [GOC:TermGenie]
synonym: "up regulation of cholesterol import" EXACT [GOC:TermGenie]
synonym: "up regulation of cholesterol uptake" EXACT [GOC:TermGenie]
synonym: "up-regulation of cholesterol import" EXACT [GOC:TermGenie]
synonym: "up-regulation of cholesterol uptake" EXACT [GOC:TermGenie]
synonym: "upregulation of cholesterol import" EXACT [GOC:TermGenie]
synonym: "upregulation of cholesterol uptake" EXACT [GOC:TermGenie]
is_a: GO:0032376 ! positive regulation of cholesterol transport
is_a: GO:0060620 ! regulation of cholesterol import
is_a: GO:2000911 ! positive regulation of sterol import
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070508 ! cholesterol import
relationship: positively_regulates GO:0070508 ! cholesterol import
created_by: sl
creation_date: 2015-04-03T14:39:06Z

[Term]
id: GO:1904110
name: regulation of plus-end directed microfilament motor activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of plus-end directed microfilament motor activity." [GO_REF:0000059, GOC:kmv, GOC:TermGenie, PMID:25717181]
synonym: "regulation of barbed-end directed actin-filament motor activity" EXACT [GOC:TermGenie]
synonym: "regulation of plus-end directed actin filament motor activity" RELATED [GOC:TermGenie]
synonym: "regulation of plus-end directed actin-filament motor activity" EXACT [GOC:TermGenie]
is_a: GO:0051336 ! regulation of hydrolase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060002 ! plus-end directed microfilament motor activity
relationship: regulates GO:0060002 ! plus-end directed microfilament motor activity
created_by: kmv
creation_date: 2015-04-03T18:28:24Z

[Term]
id: GO:1904111
name: negative regulation of plus-end directed microfilament motor activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of plus-end directed microfilament motor activity." [GO_REF:0000059, GOC:kmv, GOC:TermGenie, PMID:25717181]
synonym: "down regulation of barbed-end directed actin-filament motor activity" EXACT [GOC:TermGenie]
synonym: "down regulation of plus-end directed actin filament motor activity" RELATED [GOC:TermGenie]
synonym: "down regulation of plus-end directed actin-filament motor activity" EXACT [GOC:TermGenie]
synonym: "down regulation of plus-end directed microfilament motor activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of barbed-end directed actin-filament motor activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of plus-end directed actin filament motor activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of plus-end directed actin-filament motor activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of plus-end directed microfilament motor activity" EXACT [GOC:TermGenie]
synonym: "downregulation of barbed-end directed actin-filament motor activity" EXACT [GOC:TermGenie]
synonym: "downregulation of plus-end directed actin filament motor activity" RELATED [GOC:TermGenie]
synonym: "downregulation of plus-end directed actin-filament motor activity" EXACT [GOC:TermGenie]
synonym: "downregulation of plus-end directed microfilament motor activity" EXACT [GOC:TermGenie]
synonym: "inhibition of barbed-end directed actin-filament motor activity" NARROW [GOC:TermGenie]
synonym: "inhibition of plus-end directed actin filament motor activity" RELATED [GOC:TermGenie]
synonym: "inhibition of plus-end directed actin-filament motor activity" NARROW [GOC:TermGenie]
synonym: "inhibition of plus-end directed microfilament motor activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of barbed-end directed actin-filament motor activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of plus-end directed actin filament motor activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of plus-end directed actin-filament motor activity" EXACT [GOC:TermGenie]
is_a: GO:0051346 ! negative regulation of hydrolase activity
is_a: GO:1904110 ! regulation of plus-end directed microfilament motor activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060002 ! plus-end directed microfilament motor activity
relationship: negatively_regulates GO:0060002 ! plus-end directed microfilament motor activity
created_by: kmv
creation_date: 2015-04-03T18:28:30Z

[Term]
id: GO:1904112
name: positive regulation of plus-end directed microfilament motor activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of plus-end directed microfilament motor activity." [GO_REF:0000059, GOC:kmv, GOC:TermGenie, PMID:25717181]
synonym: "activation of barbed-end directed actin-filament motor activity" NARROW [GOC:TermGenie]
synonym: "activation of plus-end directed actin filament motor activity" RELATED [GOC:TermGenie]
synonym: "activation of plus-end directed actin-filament motor activity" NARROW [GOC:TermGenie]
synonym: "activation of plus-end directed microfilament motor activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of barbed-end directed actin-filament motor activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of plus-end directed actin filament motor activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of plus-end directed actin-filament motor activity" EXACT [GOC:TermGenie]
synonym: "up regulation of barbed-end directed actin-filament motor activity" EXACT [GOC:TermGenie]
synonym: "up regulation of plus-end directed actin filament motor activity" RELATED [GOC:TermGenie]
synonym: "up regulation of plus-end directed actin-filament motor activity" EXACT [GOC:TermGenie]
synonym: "up regulation of plus-end directed microfilament motor activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of barbed-end directed actin-filament motor activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of plus-end directed actin filament motor activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of plus-end directed actin-filament motor activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of plus-end directed microfilament motor activity" EXACT [GOC:TermGenie]
synonym: "upregulation of barbed-end directed actin-filament motor activity" EXACT [GOC:TermGenie]
synonym: "upregulation of plus-end directed actin filament motor activity" RELATED [GOC:TermGenie]
synonym: "upregulation of plus-end directed actin-filament motor activity" EXACT [GOC:TermGenie]
synonym: "upregulation of plus-end directed microfilament motor activity" EXACT [GOC:TermGenie]
is_a: GO:0051345 ! positive regulation of hydrolase activity
is_a: GO:1904110 ! regulation of plus-end directed microfilament motor activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060002 ! plus-end directed microfilament motor activity
relationship: positively_regulates GO:0060002 ! plus-end directed microfilament motor activity
created_by: kmv
creation_date: 2015-04-03T18:28:35Z

[Term]
id: GO:1904113
name: negative regulation of muscle filament sliding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of muscle filament sliding." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:25717181]
synonym: "down regulation of muscle filament sliding" EXACT [GOC:TermGenie]
synonym: "down-regulation of muscle filament sliding" EXACT [GOC:TermGenie]
synonym: "downregulation of muscle filament sliding" EXACT [GOC:TermGenie]
synonym: "inhibition of muscle filament sliding" NARROW [GOC:TermGenie]
is_a: GO:0032971 ! regulation of muscle filament sliding
is_a: GO:0045932 ! negative regulation of muscle contraction
is_a: GO:0051271 ! negative regulation of cellular component movement
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030049 ! muscle filament sliding
relationship: negatively_regulates GO:0030049 ! muscle filament sliding
created_by: kmv
creation_date: 2015-04-03T18:40:38Z

[Term]
id: GO:1904114
name: positive regulation of muscle filament sliding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of muscle filament sliding." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:25717181]
synonym: "activation of muscle filament sliding" NARROW [GOC:TermGenie]
synonym: "up regulation of muscle filament sliding" EXACT [GOC:TermGenie]
synonym: "up-regulation of muscle filament sliding" EXACT [GOC:TermGenie]
synonym: "upregulation of muscle filament sliding" EXACT [GOC:TermGenie]
is_a: GO:0032971 ! regulation of muscle filament sliding
is_a: GO:0045933 ! positive regulation of muscle contraction
is_a: GO:1903116 ! positive regulation of actin filament-based movement
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030049 ! muscle filament sliding
relationship: positively_regulates GO:0030049 ! muscle filament sliding
created_by: kmv
creation_date: 2015-04-03T18:40:44Z

[Term]
id: GO:1904115
name: axon cytoplasm
namespace: cellular_component
def: "Any cytoplasm that is part of a axon." [GO_REF:0000064, GOC:TermGenie, PMID:18667152]
synonym: "axoplasm" EXACT []
is_a: GO:0032838 ! cell projection cytoplasm
is_a: GO:0033267 ! axon part
intersection_of: GO:0005737 ! cytoplasm
intersection_of: part_of GO:0030424 ! axon
relationship: part_of GO:0030424 ! axon
created_by: sl
creation_date: 2015-04-06T18:13:14Z

[Term]
id: GO:1904116
name: response to vasopressin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vasopressin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22811487]
is_a: GO:0043434 ! response to peptide hormone
created_by: sl
creation_date: 2015-04-06T19:39:42Z

[Term]
id: GO:1904117
name: cellular response to vasopressin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vasopressin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22811487]
is_a: GO:0071375 ! cellular response to peptide hormone stimulus
is_a: GO:1904116 ! response to vasopressin
created_by: sl
creation_date: 2015-04-06T19:39:48Z

[Term]
id: GO:1904118
name: regulation of otic vesicle morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of otic vesicle morphogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:25677106]
is_a: GO:0045995 ! regulation of embryonic development
is_a: GO:2000027 ! regulation of organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071600 ! otic vesicle morphogenesis
relationship: regulates GO:0071600 ! otic vesicle morphogenesis
created_by: pga
creation_date: 2015-04-07T14:00:56Z

[Term]
id: GO:1904119
name: negative regulation of otic vesicle morphogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of otic vesicle morphogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:25677106]
synonym: "down regulation of otic vesicle morphogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of otic vesicle morphogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of otic vesicle morphogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of otic vesicle morphogenesis" NARROW [GOC:TermGenie]
is_a: GO:0045992 ! negative regulation of embryonic development
is_a: GO:1904118 ! regulation of otic vesicle morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071600 ! otic vesicle morphogenesis
relationship: negatively_regulates GO:0071600 ! otic vesicle morphogenesis
created_by: pga
creation_date: 2015-04-07T14:01:02Z

[Term]
id: GO:1904120
name: positive regulation of otic vesicle morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of otic vesicle morphogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:25677106]
synonym: "activation of otic vesicle morphogenesis" NARROW [GOC:TermGenie]
synonym: "up regulation of otic vesicle morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of otic vesicle morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of otic vesicle morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:0040019 ! positive regulation of embryonic development
is_a: GO:1904118 ! regulation of otic vesicle morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071600 ! otic vesicle morphogenesis
relationship: positively_regulates GO:0071600 ! otic vesicle morphogenesis
created_by: pga
creation_date: 2015-04-07T14:01:08Z

[Term]
id: GO:1904121
name: phosphatidylethanolamine transporter activity
namespace: molecular_function
def: "Enables the directed movement of phosphatidylethanolamine into, out of or within a cell, or between cells." [GO_REF:0000066, GOC:TermGenie, PMID:8606365]
is_a: GO:0005548 ! phospholipid transporter activity
created_by: sl
creation_date: 2015-04-07T22:51:34Z

[Term]
id: GO:1904122
name: positive regulation of fatty acid beta-oxidation by octopamine signaling pathway
namespace: biological_process
def: "An octopamine signaling pathway that results in positive regulation of fatty acid beta-oxidation." [GO_REF:0000063, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24120942]
synonym: "activation of fatty acid beta-oxidation by octopamine signaling pathway" NARROW [GOC:TermGenie]
synonym: "stimulation of fatty acid beta-oxidation by octopamine signaling pathway" NARROW [GOC:TermGenie]
synonym: "up regulation of fatty acid beta-oxidation by octopamine signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of fatty acid beta-oxidation by octopamine signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of fatty acid beta-oxidation by octopamine signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0032000 ! positive regulation of fatty acid beta-oxidation
is_a: GO:0071927 ! octopamine signaling pathway
intersection_of: GO:0071927 ! octopamine signaling pathway
intersection_of: positively_regulates GO:0006635 ! fatty acid beta-oxidation
relationship: positively_regulates GO:0006635 ! fatty acid beta-oxidation
created_by: kmv
creation_date: 2015-04-08T21:03:13Z

[Term]
id: GO:1904123
name: positive regulation of fatty acid beta-oxidation by serotonin receptor signaling pathway
namespace: biological_process
def: "A serotonin receptor signaling pathway that results in positive regulation of fatty acid beta-oxidation." [GO_REF:0000063, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24120942]
synonym: "activation of fatty acid beta-oxidation by serotonin receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "stimulation of fatty acid beta-oxidation by serotonin receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "up regulation of fatty acid beta-oxidation by serotonin receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of fatty acid beta-oxidation by serotonin receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of fatty acid beta-oxidation by serotonin receptor signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0007210 ! serotonin receptor signaling pathway
is_a: GO:0032000 ! positive regulation of fatty acid beta-oxidation
intersection_of: GO:0007210 ! serotonin receptor signaling pathway
intersection_of: positively_regulates GO:0006635 ! fatty acid beta-oxidation
relationship: positively_regulates GO:0006635 ! fatty acid beta-oxidation
created_by: kmv
creation_date: 2015-04-08T21:03:20Z

[Term]
id: GO:1904124
name: microglial cell migration
namespace: biological_process
def: "The orderly movement of a microglial cell from one site to another." [GO_REF:0000091, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
is_a: GO:0008347 ! glial cell migration
is_a: GO:0097529 ! myeloid leukocyte migration
created_by: nc
creation_date: 2015-04-10T16:04:49Z

[Term]
id: GO:1904125
name: convergent extension involved in rhombomere morphogenesis
namespace: biological_process
def: "Any convergent extension that is involved in rhombomere morphogenesis." [GO_REF:0000060, GOC:dph, GOC:TermGenie, PMID:24892953]
is_a: GO:0060027 ! convergent extension involved in gastrulation
is_a: GO:0060029 ! convergent extension involved in organogenesis
intersection_of: GO:0060026 ! convergent extension
intersection_of: part_of GO:0021593 ! rhombomere morphogenesis
relationship: part_of GO:0021593 ! rhombomere morphogenesis
created_by: dph
creation_date: 2015-04-10T21:12:50Z

[Term]
id: GO:1904126
name: convergent extension involved in notochord morphogenesis
namespace: biological_process
def: "Any convergent extension that is involved in notochord morphogenesis." [GO_REF:0000060, GOC:dph, GOC:TermGenie, PMID:24892953]
is_a: GO:0060027 ! convergent extension involved in gastrulation
is_a: GO:0060029 ! convergent extension involved in organogenesis
intersection_of: GO:0060026 ! convergent extension
intersection_of: part_of GO:0048570 ! notochord morphogenesis
relationship: part_of GO:0048570 ! notochord morphogenesis
created_by: dph
creation_date: 2015-04-10T21:12:57Z

[Term]
id: GO:1904127
name: regulation of convergent extension involved in somitogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of convergent extension involved in somitogenesis." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953]
is_a: GO:0014807 ! regulation of somitogenesis
is_a: GO:1901232 ! regulation of convergent extension involved in axis elongation
is_a: GO:1904103 ! regulation of convergent extension involved in gastrulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0090246 ! convergent extension involved in somitogenesis
relationship: regulates GO:0090246 ! convergent extension involved in somitogenesis
created_by: dph
creation_date: 2015-04-10T21:13:04Z

[Term]
id: GO:1904128
name: negative regulation of convergent extension involved in somitogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of convergent extension involved in somitogenesis." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953]
synonym: "down regulation of convergent extension involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of convergent extension involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of convergent extension involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of convergent extension involved in somitogenesis" NARROW [GOC:TermGenie]
is_a: GO:1901233 ! negative regulation of convergent extension involved in axis elongation
is_a: GO:1904104 ! negative regulation of convergent extension involved in gastrulation
is_a: GO:1904127 ! regulation of convergent extension involved in somitogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0090246 ! convergent extension involved in somitogenesis
relationship: negatively_regulates GO:0090246 ! convergent extension involved in somitogenesis
created_by: dph
creation_date: 2015-04-10T21:13:10Z

[Term]
id: GO:1904129
name: positive regulation of convergent extension involved in somitogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of convergent extension involved in somitogenesis." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953]
synonym: "activation of convergent extension involved in somitogenesis" NARROW [GOC:TermGenie]
synonym: "up regulation of convergent extension involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of convergent extension involved in somitogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of convergent extension involved in somitogenesis" EXACT [GOC:TermGenie]
is_a: GO:1901234 ! positive regulation of convergent extension involved in axis elongation
is_a: GO:1904105 ! positive regulation of convergent extension involved in gastrulation
is_a: GO:1904127 ! regulation of convergent extension involved in somitogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0090246 ! convergent extension involved in somitogenesis
relationship: positively_regulates GO:0090246 ! convergent extension involved in somitogenesis
created_by: dph
creation_date: 2015-04-10T21:13:15Z

[Term]
id: GO:1904130
name: regulation of convergent extension involved in neural plate elongation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of convergent extension involved in neural plate elongation." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953]
is_a: GO:1904103 ! regulation of convergent extension involved in gastrulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0022007 ! convergent extension involved in neural plate elongation
relationship: regulates GO:0022007 ! convergent extension involved in neural plate elongation
created_by: dph
creation_date: 2015-04-10T21:13:21Z

[Term]
id: GO:1904131
name: negative regulation of convergent extension involved in neural plate elongation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of convergent extension involved in neural plate elongation." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953]
synonym: "down regulation of convergent extension involved in neural plate elongation" EXACT [GOC:TermGenie]
synonym: "down-regulation of convergent extension involved in neural plate elongation" EXACT [GOC:TermGenie]
synonym: "downregulation of convergent extension involved in neural plate elongation" EXACT [GOC:TermGenie]
synonym: "inhibition of convergent extension involved in neural plate elongation" NARROW [GOC:TermGenie]
is_a: GO:1904104 ! negative regulation of convergent extension involved in gastrulation
is_a: GO:1904130 ! regulation of convergent extension involved in neural plate elongation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0022007 ! convergent extension involved in neural plate elongation
relationship: negatively_regulates GO:0022007 ! convergent extension involved in neural plate elongation
created_by: dph
creation_date: 2015-04-10T21:13:27Z

[Term]
id: GO:1904132
name: positive regulation of convergent extension involved in neural plate elongation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of convergent extension involved in neural plate elongation." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953]
synonym: "activation of convergent extension involved in neural plate elongation" NARROW [GOC:TermGenie]
synonym: "up regulation of convergent extension involved in neural plate elongation" EXACT [GOC:TermGenie]
synonym: "up-regulation of convergent extension involved in neural plate elongation" EXACT [GOC:TermGenie]
synonym: "upregulation of convergent extension involved in neural plate elongation" EXACT [GOC:TermGenie]
is_a: GO:1904105 ! positive regulation of convergent extension involved in gastrulation
is_a: GO:1904130 ! regulation of convergent extension involved in neural plate elongation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0022007 ! convergent extension involved in neural plate elongation
relationship: positively_regulates GO:0022007 ! convergent extension involved in neural plate elongation
created_by: dph
creation_date: 2015-04-10T21:13:33Z

[Term]
id: GO:1904133
name: regulation of convergent extension involved in rhombomere morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of convergent extension involved in rhombomere morphogenesis." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953]
is_a: GO:0051960 ! regulation of nervous system development
is_a: GO:1904103 ! regulation of convergent extension involved in gastrulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1904125 ! convergent extension involved in rhombomere morphogenesis
relationship: regulates GO:1904125 ! convergent extension involved in rhombomere morphogenesis
created_by: dph
creation_date: 2015-04-10T21:21:12Z

[Term]
id: GO:1904134
name: negative regulation of convergent extension involved in rhombomere morphogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of convergent extension involved in rhombomere morphogenesis." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953]
synonym: "down regulation of convergent extension involved in rhombomere morphogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of convergent extension involved in rhombomere morphogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of convergent extension involved in rhombomere morphogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of convergent extension involved in rhombomere morphogenesis" NARROW [GOC:TermGenie]
is_a: GO:0051961 ! negative regulation of nervous system development
is_a: GO:1904104 ! negative regulation of convergent extension involved in gastrulation
is_a: GO:1904133 ! regulation of convergent extension involved in rhombomere morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1904125 ! convergent extension involved in rhombomere morphogenesis
relationship: negatively_regulates GO:1904125 ! convergent extension involved in rhombomere morphogenesis
created_by: dph
creation_date: 2015-04-10T21:21:18Z

[Term]
id: GO:1904135
name: positive regulation of convergent extension involved in rhombomere morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of convergent extension involved in rhombomere morphogenesis." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953]
synonym: "activation of convergent extension involved in rhombomere morphogenesis" NARROW [GOC:TermGenie]
synonym: "up regulation of convergent extension involved in rhombomere morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of convergent extension involved in rhombomere morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of convergent extension involved in rhombomere morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:0051962 ! positive regulation of nervous system development
is_a: GO:1904105 ! positive regulation of convergent extension involved in gastrulation
is_a: GO:1904133 ! regulation of convergent extension involved in rhombomere morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1904125 ! convergent extension involved in rhombomere morphogenesis
relationship: positively_regulates GO:1904125 ! convergent extension involved in rhombomere morphogenesis
created_by: dph
creation_date: 2015-04-10T21:21:24Z

[Term]
id: GO:1904136
name: regulation of convergent extension involved in notochord morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of convergent extension involved in notochord morphogenesis." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953]
is_a: GO:1904103 ! regulation of convergent extension involved in gastrulation
is_a: GO:2000027 ! regulation of organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1904126 ! convergent extension involved in notochord morphogenesis
relationship: regulates GO:1904126 ! convergent extension involved in notochord morphogenesis
created_by: dph
creation_date: 2015-04-10T21:21:30Z

[Term]
id: GO:1904137
name: negative regulation of convergent extension involved in notochord morphogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of convergent extension involved in notochord morphogenesis." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953]
synonym: "down regulation of convergent extension involved in notochord morphogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of convergent extension involved in notochord morphogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of convergent extension involved in notochord morphogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of convergent extension involved in notochord morphogenesis" NARROW [GOC:TermGenie]
is_a: GO:1904104 ! negative regulation of convergent extension involved in gastrulation
is_a: GO:1904136 ! regulation of convergent extension involved in notochord morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1904126 ! convergent extension involved in notochord morphogenesis
relationship: negatively_regulates GO:1904126 ! convergent extension involved in notochord morphogenesis
created_by: dph
creation_date: 2015-04-10T21:21:36Z

[Term]
id: GO:1904138
name: positive regulation of convergent extension involved in notochord morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of convergent extension involved in notochord morphogenesis." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953]
synonym: "activation of convergent extension involved in notochord morphogenesis" NARROW [GOC:TermGenie]
synonym: "up regulation of convergent extension involved in notochord morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of convergent extension involved in notochord morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of convergent extension involved in notochord morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:1904105 ! positive regulation of convergent extension involved in gastrulation
is_a: GO:1904136 ! regulation of convergent extension involved in notochord morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1904126 ! convergent extension involved in notochord morphogenesis
relationship: positively_regulates GO:1904126 ! convergent extension involved in notochord morphogenesis
created_by: dph
creation_date: 2015-04-10T21:21:41Z

[Term]
id: GO:1904139
name: regulation of microglial cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of microglial cell migration." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
is_a: GO:0002685 ! regulation of leukocyte migration
is_a: GO:1903975 ! regulation of glial cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1904124 ! microglial cell migration
relationship: regulates GO:1904124 ! microglial cell migration
created_by: nc
creation_date: 2015-04-13T09:06:57Z

[Term]
id: GO:1904140
name: negative regulation of microglial cell migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of microglial cell migration." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
synonym: "down regulation of microglial cell migration" EXACT [GOC:TermGenie]
synonym: "down-regulation of microglial cell migration" EXACT [GOC:TermGenie]
synonym: "downregulation of microglial cell migration" EXACT [GOC:TermGenie]
synonym: "inhibition of microglial cell migration" NARROW [GOC:TermGenie]
is_a: GO:0002686 ! negative regulation of leukocyte migration
is_a: GO:1903976 ! negative regulation of glial cell migration
is_a: GO:1904139 ! regulation of microglial cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1904124 ! microglial cell migration
relationship: negatively_regulates GO:1904124 ! microglial cell migration
created_by: nc
creation_date: 2015-04-13T09:07:03Z

[Term]
id: GO:1904141
name: positive regulation of microglial cell migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of microglial cell migration." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
synonym: "activation of microglial cell migration" NARROW [GOC:TermGenie]
synonym: "up regulation of microglial cell migration" EXACT [GOC:TermGenie]
synonym: "up-regulation of microglial cell migration" EXACT [GOC:TermGenie]
synonym: "upregulation of microglial cell migration" EXACT [GOC:TermGenie]
is_a: GO:0002687 ! positive regulation of leukocyte migration
is_a: GO:1903977 ! positive regulation of glial cell migration
is_a: GO:1904139 ! regulation of microglial cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1904124 ! microglial cell migration
relationship: positively_regulates GO:1904124 ! microglial cell migration
created_by: nc
creation_date: 2015-04-13T09:07:11Z

[Term]
id: GO:1904142
name: negative regulation of carotenoid biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of carotenoid biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:25675505]
synonym: "down regulation of carotenoid anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of carotenoid biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of carotenoid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of carotenoid formation" EXACT [GOC:TermGenie]
synonym: "down regulation of carotenoid synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of carotenoid anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of carotenoid biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of carotenoid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of carotenoid formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of carotenoid synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of carotenoid anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of carotenoid biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of carotenoid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of carotenoid formation" EXACT [GOC:TermGenie]
synonym: "downregulation of carotenoid synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of carotenoid anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of carotenoid biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of carotenoid biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of carotenoid formation" NARROW [GOC:TermGenie]
synonym: "inhibition of carotenoid synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of carotenoid anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of carotenoid biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of carotenoid formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of carotenoid synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0045827 ! negative regulation of isoprenoid metabolic process
is_a: GO:0051055 ! negative regulation of lipid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016117 ! carotenoid biosynthetic process
relationship: negatively_regulates GO:0016117 ! carotenoid biosynthetic process
created_by: tb
creation_date: 2015-04-13T19:39:13Z

[Term]
id: GO:1904143
name: positive regulation of carotenoid biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of carotenoid biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:25675505]
synonym: "activation of carotenoid anabolism" NARROW [GOC:TermGenie]
synonym: "activation of carotenoid biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of carotenoid biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of carotenoid formation" NARROW [GOC:TermGenie]
synonym: "activation of carotenoid synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of carotenoid anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of carotenoid biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of carotenoid formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of carotenoid synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of carotenoid anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of carotenoid biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of carotenoid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of carotenoid formation" EXACT [GOC:TermGenie]
synonym: "up regulation of carotenoid synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of carotenoid anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of carotenoid biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of carotenoid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of carotenoid formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of carotenoid synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of carotenoid anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of carotenoid biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of carotenoid biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of carotenoid formation" EXACT [GOC:TermGenie]
synonym: "upregulation of carotenoid synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process
is_a: GO:0046889 ! positive regulation of lipid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016117 ! carotenoid biosynthetic process
relationship: positively_regulates GO:0016117 ! carotenoid biosynthetic process
created_by: tb
creation_date: 2015-04-13T19:39:19Z

[Term]
id: GO:1904144
name: phosphatidylinositol phosphate phosphatase complex
namespace: cellular_component
def: "A protein complex which is capable of phosphatidylinositol phosphate phosphatase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:12525165]
comment: An example of this is ACPP in human (P15309) in PMID:12525165 (inferred from physical interaction).
synonym: "prostatic acid phosphatase complex" NARROW []
is_a: GO:1903293 ! phosphatase complex
created_by: bhm
creation_date: 2015-04-14T11:22:53Z

[Term]
id: GO:1904145
name: negative regulation of meiotic cell cycle process involved in oocyte maturation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation." [GO_REF:0000058, GOC:TermGenie, PMID:22674394]
synonym: "down regulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie]
synonym: "down-regulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie]
synonym: "downregulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie]
synonym: "inhibition of meiotic cell cycle process involved in oocyte maturation" NARROW [GOC:TermGenie]
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0051447 ! negative regulation of meiotic cell cycle
is_a: GO:1900194 ! negative regulation of oocyte maturation
is_a: GO:1903538 ! regulation of meiotic cell cycle process involved in oocyte maturation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1903537 ! meiotic cell cycle process involved in oocyte maturation
relationship: negatively_regulates GO:1903537 ! meiotic cell cycle process involved in oocyte maturation
created_by: tb
creation_date: 2015-04-14T15:59:22Z

[Term]
id: GO:1904146
name: positive regulation of meiotic cell cycle process involved in oocyte maturation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation." [GO_REF:0000058, GOC:TermGenie, PMID:22674394]
synonym: "activation of meiotic cell cycle process involved in oocyte maturation" NARROW [GOC:TermGenie]
synonym: "up regulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie]
synonym: "up-regulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie]
synonym: "upregulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie]
is_a: GO:0051446 ! positive regulation of meiotic cell cycle
is_a: GO:0090068 ! positive regulation of cell cycle process
is_a: GO:1900195 ! positive regulation of oocyte maturation
is_a: GO:1903538 ! regulation of meiotic cell cycle process involved in oocyte maturation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1903537 ! meiotic cell cycle process involved in oocyte maturation
relationship: positively_regulates GO:1903537 ! meiotic cell cycle process involved in oocyte maturation
created_by: tb
creation_date: 2015-04-14T15:59:28Z

[Term]
id: GO:1904147
name: response to nonylphenol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nonylphenol stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:19260726]
is_a: GO:0010033 ! response to organic substance
created_by: sl
creation_date: 2015-04-14T17:01:44Z

[Term]
id: GO:1904148
name: cellular response to nonylphenol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nonylphenol stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:19260726]
is_a: GO:0070887 ! cellular response to chemical stimulus
is_a: GO:1904147 ! response to nonylphenol
created_by: sl
creation_date: 2015-04-14T17:01:50Z

[Term]
id: GO:1904149
name: regulation of microglial cell mediated cytotoxicity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of microglial cell mediated cytotoxicity." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity
is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0090634 ! microglial cell mediated cytotoxicity
relationship: regulates GO:0090634 ! microglial cell mediated cytotoxicity
created_by: nc
creation_date: 2015-04-15T08:05:29Z

[Term]
id: GO:1904150
name: negative regulation of microglial cell mediated cytotoxicity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of microglial cell mediated cytotoxicity." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
synonym: "down regulation of microglial cell mediated cytotoxicity" EXACT [GOC:TermGenie]
synonym: "down-regulation of microglial cell mediated cytotoxicity" EXACT [GOC:TermGenie]
synonym: "downregulation of microglial cell mediated cytotoxicity" EXACT [GOC:TermGenie]
synonym: "inhibition of microglial cell mediated cytotoxicity" NARROW [GOC:TermGenie]
is_a: GO:0001911 ! negative regulation of leukocyte mediated cytotoxicity
is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity
is_a: GO:1904149 ! regulation of microglial cell mediated cytotoxicity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0090634 ! microglial cell mediated cytotoxicity
relationship: negatively_regulates GO:0090634 ! microglial cell mediated cytotoxicity
created_by: nc
creation_date: 2015-04-15T08:05:35Z

[Term]
id: GO:1904151
name: positive regulation of microglial cell mediated cytotoxicity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of microglial cell mediated cytotoxicity." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
synonym: "activation of microglial cell mediated cytotoxicity" NARROW [GOC:TermGenie]
synonym: "up regulation of microglial cell mediated cytotoxicity" EXACT [GOC:TermGenie]
synonym: "up-regulation of microglial cell mediated cytotoxicity" EXACT [GOC:TermGenie]
synonym: "upregulation of microglial cell mediated cytotoxicity" EXACT [GOC:TermGenie]
is_a: GO:0001912 ! positive regulation of leukocyte mediated cytotoxicity
is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity
is_a: GO:1904149 ! regulation of microglial cell mediated cytotoxicity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0090634 ! microglial cell mediated cytotoxicity
relationship: positively_regulates GO:0090634 ! microglial cell mediated cytotoxicity
created_by: nc
creation_date: 2015-04-15T08:05:42Z

[Term]
id: GO:1904152
name: regulation of retrograde protein transport, ER to cytosol
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of retrograde protein transport, ER to cytosol." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18555783]
synonym: "regulation of protein dislocation from ER" EXACT [GOC:TermGenie]
synonym: "regulation of protein retrotranslocation from ER" EXACT [GOC:bf]
synonym: "regulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie]
is_a: GO:0070861 ! regulation of protein exit from endoplasmic reticulum
is_a: GO:1904292 ! regulation of ERAD pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030970 ! retrograde protein transport, ER to cytosol
relationship: regulates GO:0030970 ! retrograde protein transport, ER to cytosol
created_by: bf
creation_date: 2015-04-15T09:23:06Z

[Term]
id: GO:1904153
name: negative regulation of retrograde protein transport, ER to cytosol
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of retrograde protein transport, ER to cytosol." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18555783]
synonym: "down regulation of protein dislocation from ER" EXACT [GOC:TermGenie]
synonym: "down regulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie]
synonym: "down regulation of retrograde protein transport, ER to cytosol" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein dislocation from ER" EXACT [GOC:TermGenie]
synonym: "down-regulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie]
synonym: "down-regulation of retrograde protein transport, ER to cytosol" EXACT [GOC:TermGenie]
synonym: "downregulation of protein dislocation from ER" EXACT [GOC:TermGenie]
synonym: "downregulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie]
synonym: "downregulation of retrograde protein transport, ER to cytosol" EXACT [GOC:TermGenie]
synonym: "inhibition of protein dislocation from ER" NARROW [GOC:TermGenie]
synonym: "inhibition of retrograde protein transport, endoplasmic reticulum to cytosol" NARROW [GOC:TermGenie]
synonym: "inhibition of retrograde protein transport, ER to cytosol" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein dislocation from ER" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein retrotranslocation from ER" EXACT [GOC:bf]
synonym: "negative regulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie]
is_a: GO:0070862 ! negative regulation of protein exit from endoplasmic reticulum
is_a: GO:1904152 ! regulation of retrograde protein transport, ER to cytosol
is_a: GO:1904293 ! negative regulation of ERAD pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030970 ! retrograde protein transport, ER to cytosol
relationship: negatively_regulates GO:0030970 ! retrograde protein transport, ER to cytosol
created_by: bf
creation_date: 2015-04-15T09:23:13Z

[Term]
id: GO:1904154
name: positive regulation of retrograde protein transport, ER to cytosol
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of retrograde protein transport, ER to cytosol." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18555783]
synonym: "activation of protein dislocation from ER" NARROW [GOC:TermGenie]
synonym: "activation of retrograde protein transport, endoplasmic reticulum to cytosol" NARROW [GOC:TermGenie]
synonym: "activation of retrograde protein transport, ER to cytosol" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein dislocation from ER" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein retrotranslocation from ER" EXACT [GOC:bf]
synonym: "positive regulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie]
synonym: "up regulation of protein dislocation from ER" EXACT [GOC:TermGenie]
synonym: "up regulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie]
synonym: "up regulation of retrograde protein transport, ER to cytosol" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein dislocation from ER" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein retrotranslocation from ER" EXACT [GOC:bf]
synonym: "up-regulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie]
synonym: "up-regulation of retrograde protein transport, ER to cytosol" EXACT [GOC:TermGenie]
synonym: "upregulation of protein dislocation from ER" EXACT [GOC:TermGenie]
synonym: "upregulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie]
synonym: "upregulation of retrograde protein transport, ER to cytosol" EXACT [GOC:TermGenie]
is_a: GO:0070863 ! positive regulation of protein exit from endoplasmic reticulum
is_a: GO:1904152 ! regulation of retrograde protein transport, ER to cytosol
is_a: GO:1904294 ! positive regulation of ERAD pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030970 ! retrograde protein transport, ER to cytosol
relationship: positively_regulates GO:0030970 ! retrograde protein transport, ER to cytosol
created_by: bf
creation_date: 2015-04-15T09:23:19Z

[Term]
id: GO:1904155
name: DN2 thymocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a DN2 thymocyte. A DN2 thymocyte is a CD4-,CD8- thymocyte that is also CD44+,CD25-." [GO_REF:0000086, GOC:dph, GOC:TermGenie, PMID:25398325]
is_a: GO:0033077 ! T cell differentiation in thymus
created_by: dph
creation_date: 2015-04-15T12:52:53Z

[Term]
id: GO:1904156
name: DN3 thymocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a DN3 thymocyte. A DN3 thymocyte is a CD4-,CD8- thymocyte that is also CD44+,CD25+." [GO_REF:0000086, GOC:dph, GOC:TermGenie, PMID:25398325]
is_a: GO:0033077 ! T cell differentiation in thymus
created_by: dph
creation_date: 2015-04-15T12:53:00Z

[Term]
id: GO:1904157
name: DN4 thymocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a DN4 thymocyte. A DN4 thymocyte is a CD4-,CD8- thymocyte that is also CD44-,CD25-." [GO_REF:0000086, GOC:dph, GOC:TermGenie, PMID:25398325]
is_a: GO:0033077 ! T cell differentiation in thymus
created_by: dph
creation_date: 2015-04-15T12:53:07Z

[Term]
id: GO:1904158
name: axonemal central apparatus assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an axonemal central apparatus." [GO_REF:0000079, GOC:krc, GOC:TermGenie, PMID:9295136]
synonym: "axonemal central apparatus formation" EXACT [GOC:TermGenie]
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
relationship: part_of GO:0035082 ! axoneme assembly
created_by: krc
creation_date: 2015-04-16T18:46:11Z

[Term]
id: GO:1904159
name: megasporocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a megasporocyte." [GO_REF:0000086, GOC:tair_curators, GOC:TermGenie]
comment: The process aimed at the progression of a megasporocyte cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. A megasporocyte is a diploid (2n) cell that undergoes meiosis and forms four haploid (1n) megaspores; also called megaspore mother cell.
synonym: "megaspore mother cell differentiation" EXACT [GOC:tair_curators]
is_a: GO:0048533 ! sporocyte differentiation
created_by: lr
creation_date: 2015-04-17T20:25:14Z

[Term]
id: GO:1904160
name: protein localization to chloroplast starch grain
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a chloroplast starch grain." [GO_REF:0000087, GOC:TermGenie, PMID:25710501]
synonym: "protein localisation in chloroplast starch grain" EXACT [GOC:TermGenie]
synonym: "protein localisation to chloroplast starch grain" EXACT [GOC:TermGenie]
synonym: "protein localization in chloroplast starch grain" EXACT [GOC:TermGenie]
is_a: GO:0072598 ! protein localization to chloroplast
created_by: lr
creation_date: 2015-04-20T18:06:17Z

[Term]
id: GO:1904161
name: DNA synthesis involved in UV-damage excision repair
namespace: biological_process
def: "Any DNA synthesis that is involved in UV-damage excision repair." [GO_REF:0000060, GOC:TermGenie, PMID:10704216]
synonym: "DNA synthesis during UV-damage excision repair" RELATED [GOC:TermGenie]
synonym: "DNA synthesis during UV-damaged DNA endonuclease-dependent excision repair" RELATED [GOC:TermGenie]
synonym: "DNA synthesis during UVDE-dependent excision repair" RELATED [GOC:TermGenie]
synonym: "DNA synthesis during UVER" RELATED [GOC:TermGenie]
synonym: "DNA synthesis involved in AER" RELATED [GOC:mah, PMID:10704216]
synonym: "DNA synthesis involved in alternative excision repair" RELATED [GOC:mah, PMID:10704216]
synonym: "DNA synthesis involved in UV-damaged DNA endonuclease-dependent excision repair" EXACT [GOC:TermGenie]
synonym: "DNA synthesis involved in UVDE-dependent excision repair" EXACT [GOC:TermGenie]
synonym: "DNA synthesis involved in UVER" EXACT [GOC:TermGenie]
synonym: "mitotic DNA repair synthesis involved in UV-damage excision repair" NARROW [GOC:TermGenie]
synonym: "mitotic DNA repair synthesis involved in UV-damaged DNA endonuclease-dependent excision repair" NARROW [GOC:TermGenie]
synonym: "mitotic DNA repair synthesis involved in UVDE-dependent excision repair" NARROW [GOC:TermGenie]
synonym: "mitotic DNA repair synthesis involved in UVER" NARROW [GOC:TermGenie]
is_a: GO:0000731 ! DNA synthesis involved in DNA repair
intersection_of: GO:0000731 ! DNA synthesis involved in DNA repair
intersection_of: part_of GO:0070914 ! UV-damage excision repair
relationship: part_of GO:0070914 ! UV-damage excision repair
created_by: mah
creation_date: 2015-04-21T14:53:12Z

[Term]
id: GO:1904162
name: 5'-3' exodeoxyribonuclease activity involved in UV-damage excision repair
namespace: molecular_function
def: "Any 5'-3' exodeoxyribonuclease activity that is involved in UV-damage excision repair." [GO_REF:0000061, GOC:TermGenie, PMID:10704216]
synonym: "5'-3' exodeoxyribonuclease activity involved in AER" RELATED [GOC:mah]
synonym: "5'-3' exodeoxyribonuclease activity involved in alternative excision repair" RELATED [GOC:mah]
synonym: "5'-3' exodeoxyribonuclease activity involved in UV-damaged DNA endonuclease-dependent excision repair" EXACT [GOC:TermGenie]
synonym: "5'-3' exodeoxyribonuclease activity involved in UVDE-dependent excision repair" EXACT [GOC:TermGenie]
synonym: "5'-3' exodeoxyribonuclease activity involved in UVER" EXACT [GOC:TermGenie]
is_a: GO:0035312 ! 5'-3' exodeoxyribonuclease activity
intersection_of: GO:0035312 ! 5'-3' exodeoxyribonuclease activity
intersection_of: part_of GO:0070914 ! UV-damage excision repair
relationship: part_of GO:0070914 ! UV-damage excision repair
created_by: mah
creation_date: 2015-04-21T14:53:19Z

[Term]
id: GO:1904163
name: obsolete regulation of triglyceride homeostasis
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of triglyceride homeostasis." [GO_REF:0000058, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:22541436]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "regulation of triacylglycerol homeostasis" EXACT [GOC:TermGenie]
is_obsolete: true
created_by: rph
creation_date: 2015-04-22T11:04:43Z

[Term]
id: GO:1904164
name: obsolete negative regulation of triglyceride homeostasis
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of triglyceride homeostasis." [GO_REF:0000058, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:22541436]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "down regulation of triacylglycerol homeostasis" EXACT [GOC:TermGenie]
synonym: "down regulation of triglyceride homeostasis" EXACT [GOC:TermGenie]
synonym: "down-regulation of triacylglycerol homeostasis" EXACT [GOC:TermGenie]
synonym: "down-regulation of triglyceride homeostasis" EXACT [GOC:TermGenie]
synonym: "downregulation of triacylglycerol homeostasis" EXACT [GOC:TermGenie]
synonym: "downregulation of triglyceride homeostasis" EXACT [GOC:TermGenie]
synonym: "inhibition of triacylglycerol homeostasis" NARROW [GOC:TermGenie]
synonym: "inhibition of triglyceride homeostasis" NARROW [GOC:TermGenie]
synonym: "negative regulation of triacylglycerol homeostasis" EXACT [GOC:TermGenie]
is_obsolete: true
created_by: rph
creation_date: 2015-04-22T11:04:49Z

[Term]
id: GO:1904165
name: obsolete positive regulation of triglyceride homeostasis
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of triglyceride homeostasis." [GO_REF:0000058, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:22541436]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "activation of triacylglycerol homeostasis" NARROW [GOC:TermGenie]
synonym: "activation of triglyceride homeostasis" NARROW [GOC:TermGenie]
synonym: "positive regulation of triacylglycerol homeostasis" EXACT [GOC:TermGenie]
synonym: "up regulation of triacylglycerol homeostasis" EXACT [GOC:TermGenie]
synonym: "up regulation of triglyceride homeostasis" EXACT [GOC:TermGenie]
synonym: "up-regulation of triacylglycerol homeostasis" EXACT [GOC:TermGenie]
synonym: "up-regulation of triglyceride homeostasis" EXACT [GOC:TermGenie]
synonym: "upregulation of triacylglycerol homeostasis" EXACT [GOC:TermGenie]
synonym: "upregulation of triglyceride homeostasis" EXACT [GOC:TermGenie]
is_obsolete: true
created_by: rph
creation_date: 2015-04-22T11:04:55Z

[Term]
id: GO:1904166
name: obsolete negative regulation of cholesterol homeostasis
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of cholesterol homeostasis." [GO_REF:0000058, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:22541436]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "down regulation of cholesterol homeostasis" EXACT [GOC:TermGenie]
synonym: "down-regulation of cholesterol homeostasis" EXACT [GOC:TermGenie]
synonym: "downregulation of cholesterol homeostasis" EXACT [GOC:TermGenie]
synonym: "inhibition of cholesterol homeostasis" NARROW [GOC:TermGenie]
is_obsolete: true
created_by: rph
creation_date: 2015-04-22T11:11:12Z

[Term]
id: GO:1904167
name: regulation of thyroid hormone receptor activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of thyroid hormone receptor activity." [GO_REF:0000059, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:22541436]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0010469 ! regulation of receptor activity
is_a: GO:0051090 ! regulation of sequence-specific DNA binding transcription factor activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004887 ! thyroid hormone receptor activity
relationship: regulates GO:0004887 ! thyroid hormone receptor activity
created_by: rph
creation_date: 2015-04-22T12:22:04Z

[Term]
id: GO:1904168
name: negative regulation of thyroid hormone receptor activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of thyroid hormone receptor activity." [GO_REF:0000059, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:22541436]
synonym: "down regulation of thyroid hormone receptor activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of thyroid hormone receptor activity" EXACT [GOC:TermGenie]
synonym: "downregulation of thyroid hormone receptor activity" EXACT [GOC:TermGenie]
synonym: "inhibition of thyroid hormone receptor activity" NARROW [GOC:TermGenie]
is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0043433 ! negative regulation of sequence-specific DNA binding transcription factor activity
is_a: GO:1904167 ! regulation of thyroid hormone receptor activity
is_a: GO:2000272 ! negative regulation of receptor activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004887 ! thyroid hormone receptor activity
relationship: negatively_regulates GO:0004887 ! thyroid hormone receptor activity
created_by: rph
creation_date: 2015-04-22T12:22:10Z

[Term]
id: GO:1904169
name: positive regulation of thyroid hormone receptor activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of thyroid hormone receptor activity." [GO_REF:0000059, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:22541436]
synonym: "activation of thyroid hormone receptor activity" NARROW [GOC:TermGenie]
synonym: "up regulation of thyroid hormone receptor activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of thyroid hormone receptor activity" EXACT [GOC:TermGenie]
synonym: "upregulation of thyroid hormone receptor activity" EXACT [GOC:TermGenie]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
is_a: GO:0051091 ! positive regulation of sequence-specific DNA binding transcription factor activity
is_a: GO:1904167 ! regulation of thyroid hormone receptor activity
is_a: GO:2000273 ! positive regulation of receptor activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004887 ! thyroid hormone receptor activity
relationship: positively_regulates GO:0004887 ! thyroid hormone receptor activity
created_by: rph
creation_date: 2015-04-22T12:22:16Z

[Term]
id: GO:1904170
name: regulation of bleb assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of bleb assembly." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:25651887]
synonym: "regulation of cell blebbing" EXACT [GOC:TermGenie]
is_a: GO:0060491 ! regulation of cell projection assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032060 ! bleb assembly
relationship: regulates GO:0032060 ! bleb assembly
created_by: als
creation_date: 2015-04-23T09:32:19Z

[Term]
id: GO:1904171
name: negative regulation of bleb assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of bleb assembly." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:25651887]
synonym: "down regulation of bleb assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of cell blebbing" EXACT [GOC:TermGenie]
synonym: "down-regulation of bleb assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell blebbing" EXACT [GOC:TermGenie]
synonym: "downregulation of bleb assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of cell blebbing" EXACT [GOC:TermGenie]
synonym: "inhibition of bleb assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of cell blebbing" NARROW [GOC:TermGenie]
synonym: "negative regulation of cell blebbing" EXACT [GOC:TermGenie]
is_a: GO:0031345 ! negative regulation of cell projection organization
is_a: GO:1904170 ! regulation of bleb assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032060 ! bleb assembly
relationship: negatively_regulates GO:0032060 ! bleb assembly
created_by: als
creation_date: 2015-04-23T09:32:25Z

[Term]
id: GO:1904172
name: positive regulation of bleb assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of bleb assembly." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:25651887]
synonym: "activation of bleb assembly" NARROW [GOC:TermGenie]
synonym: "activation of cell blebbing" NARROW [GOC:TermGenie]
synonym: "positive regulation of cell blebbing" EXACT [GOC:TermGenie]
synonym: "up regulation of bleb assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of cell blebbing" EXACT [GOC:TermGenie]
synonym: "up-regulation of bleb assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell blebbing" EXACT [GOC:TermGenie]
synonym: "upregulation of bleb assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of cell blebbing" EXACT [GOC:TermGenie]
is_a: GO:0031346 ! positive regulation of cell projection organization
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:1904170 ! regulation of bleb assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032060 ! bleb assembly
relationship: positively_regulates GO:0032060 ! bleb assembly
created_by: als
creation_date: 2015-04-23T09:32:31Z

[Term]
id: GO:1904173
name: regulation of histone demethylase activity (H3-K4 specific)
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of histone demethylase activity (H3-K4 specific)." [GO_REF:0000059, GOC:dph, GOC:TermGenie, PMID:24843136]
is_a: GO:0031056 ! regulation of histone modification
is_a: GO:0050790 ! regulation of catalytic activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032453 ! histone demethylase activity (H3-K4 specific)
relationship: regulates GO:0032453 ! histone demethylase activity (H3-K4 specific)
created_by: dph
creation_date: 2015-04-24T19:29:32Z

[Term]
id: GO:1904174
name: negative regulation of histone demethylase activity (H3-K4 specific)
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone demethylase activity (H3-K4 specific)." [GO_REF:0000059, GOC:dph, GOC:TermGenie, PMID:24843136]
synonym: "down regulation of histone demethylase activity (H3-K4 specific)" EXACT [GOC:TermGenie]
synonym: "down-regulation of histone demethylase activity (H3-K4 specific)" EXACT [GOC:TermGenie]
synonym: "downregulation of histone demethylase activity (H3-K4 specific)" EXACT [GOC:TermGenie]
synonym: "inhibition of histone demethylase activity (H3-K4 specific)" NARROW [GOC:TermGenie]
is_a: GO:0031057 ! negative regulation of histone modification
is_a: GO:0043086 ! negative regulation of catalytic activity
is_a: GO:1904173 ! regulation of histone demethylase activity (H3-K4 specific)
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032453 ! histone demethylase activity (H3-K4 specific)
relationship: negatively_regulates GO:0032453 ! histone demethylase activity (H3-K4 specific)
created_by: dph
creation_date: 2015-04-24T19:29:38Z

[Term]
id: GO:1904175
name: positive regulation of histone demethylase activity (H3-K4 specific)
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of histone demethylase activity (H3-K4 specific)." [GO_REF:0000059, GOC:dph, GOC:TermGenie, PMID:24843136]
synonym: "activation of histone demethylase activity (H3-K4 specific)" NARROW [GOC:TermGenie]
synonym: "up regulation of histone demethylase activity (H3-K4 specific)" EXACT [GOC:TermGenie]
synonym: "up-regulation of histone demethylase activity (H3-K4 specific)" EXACT [GOC:TermGenie]
synonym: "upregulation of histone demethylase activity (H3-K4 specific)" EXACT [GOC:TermGenie]
is_a: GO:0031058 ! positive regulation of histone modification
is_a: GO:0043085 ! positive regulation of catalytic activity
is_a: GO:1904173 ! regulation of histone demethylase activity (H3-K4 specific)
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032453 ! histone demethylase activity (H3-K4 specific)
relationship: positively_regulates GO:0032453 ! histone demethylase activity (H3-K4 specific)
created_by: dph
creation_date: 2015-04-24T19:29:45Z

[Term]
id: GO:1904176
name: carbon phosphorus lyase complex
namespace: cellular_component
def: "A protein complex which is capable of carbon phosphorus lyase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, IntAct:EBI-6471348, PMID:17993513, PMID:21705661, PMID:22089136, PMID:23830682]
comment: An example of this is PhnJ in E. coli (P16688) in PMID:22089136 (inferred from direct assay).
is_a: GO:1902494 ! catalytic complex
created_by: bhm
creation_date: 2015-04-29T08:17:13Z

[Term]
id: GO:1904177
name: regulation of adipose tissue development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of adipose tissue development." [GO_REF:0000058, GOC:TermGenie, PMID:23081848]
synonym: "regulation of adipogenesis" RELATED [GOC:TermGenie]
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060612 ! adipose tissue development
relationship: regulates GO:0060612 ! adipose tissue development
created_by: sl
creation_date: 2015-04-29T20:01:01Z

[Term]
id: GO:1904178
name: negative regulation of adipose tissue development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of adipose tissue development." [GO_REF:0000058, GOC:TermGenie, PMID:23081848]
synonym: "down regulation of adipogenesis" RELATED [GOC:TermGenie]
synonym: "down regulation of adipose tissue development" EXACT [GOC:TermGenie]
synonym: "down-regulation of adipogenesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of adipose tissue development" EXACT [GOC:TermGenie]
synonym: "downregulation of adipogenesis" RELATED [GOC:TermGenie]
synonym: "downregulation of adipose tissue development" EXACT [GOC:TermGenie]
synonym: "inhibition of adipogenesis" RELATED [GOC:TermGenie]
synonym: "inhibition of adipose tissue development" NARROW [GOC:TermGenie]
synonym: "negative regulation of adipogenesis" RELATED [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1904177 ! regulation of adipose tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060612 ! adipose tissue development
relationship: negatively_regulates GO:0060612 ! adipose tissue development
created_by: sl
creation_date: 2015-04-29T20:01:07Z

[Term]
id: GO:1904179
name: positive regulation of adipose tissue development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of adipose tissue development." [GO_REF:0000058, GOC:TermGenie, PMID:23081848]
synonym: "activation of adipogenesis" RELATED [GOC:TermGenie]
synonym: "activation of adipose tissue development" NARROW [GOC:TermGenie]
synonym: "positive regulation of adipogenesis" RELATED [GOC:TermGenie]
synonym: "up regulation of adipogenesis" RELATED [GOC:TermGenie]
synonym: "up regulation of adipose tissue development" EXACT [GOC:TermGenie]
synonym: "up-regulation of adipogenesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of adipose tissue development" EXACT [GOC:TermGenie]
synonym: "upregulation of adipogenesis" RELATED [GOC:TermGenie]
synonym: "upregulation of adipose tissue development" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1904177 ! regulation of adipose tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060612 ! adipose tissue development
relationship: positively_regulates GO:0060612 ! adipose tissue development
created_by: sl
creation_date: 2015-04-29T20:01:13Z

[Term]
id: GO:1904180
name: negative regulation of membrane depolarization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of membrane depolarization." [GO_REF:0000058, GOC:TermGenie, PMID:20826763]
synonym: "down regulation of membrane depolarization" EXACT [GOC:TermGenie]
synonym: "down-regulation of membrane depolarization" EXACT [GOC:TermGenie]
synonym: "downregulation of membrane depolarization" EXACT [GOC:TermGenie]
synonym: "inhibition of membrane depolarization" NARROW [GOC:TermGenie]
is_a: GO:0003254 ! regulation of membrane depolarization
is_a: GO:0048519 ! negative regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051899 ! membrane depolarization
relationship: negatively_regulates GO:0051899 ! membrane depolarization
created_by: sl
creation_date: 2015-04-29T22:29:25Z

[Term]
id: GO:1904181
name: positive regulation of membrane depolarization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of membrane depolarization." [GO_REF:0000058, GOC:TermGenie, PMID:20826763]
synonym: "activation of membrane depolarization" NARROW [GOC:TermGenie]
synonym: "up regulation of membrane depolarization" EXACT [GOC:TermGenie]
synonym: "up-regulation of membrane depolarization" EXACT [GOC:TermGenie]
synonym: "upregulation of membrane depolarization" EXACT [GOC:TermGenie]
is_a: GO:0003254 ! regulation of membrane depolarization
is_a: GO:0048518 ! positive regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051899 ! membrane depolarization
relationship: positively_regulates GO:0051899 ! membrane depolarization
created_by: sl
creation_date: 2015-04-29T22:29:31Z

[Term]
id: GO:1904182
name: regulation of pyruvate dehydrogenase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pyruvate dehydrogenase activity." [GO_REF:0000059, GOC:dph, GOC:TermGenie, PMID:25525879]
synonym: "regulation of pyruvic acid dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "regulation of pyruvic dehydrogenase activity" EXACT [GOC:TermGenie]
is_a: GO:0051341 ! regulation of oxidoreductase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004738 ! pyruvate dehydrogenase activity
relationship: regulates GO:0004738 ! pyruvate dehydrogenase activity
created_by: dph
creation_date: 2015-05-05T14:17:27Z

[Term]
id: GO:1904183
name: negative regulation of pyruvate dehydrogenase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of pyruvate dehydrogenase activity." [GO_REF:0000059, GOC:dph, GOC:TermGenie, PMID:25525879]
synonym: "down regulation of pyruvate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of pyruvic acid dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of pyruvic dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of pyruvate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of pyruvic acid dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of pyruvic dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of pyruvate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of pyruvic acid dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of pyruvic dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of pyruvate dehydrogenase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of pyruvic acid dehydrogenase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of pyruvic dehydrogenase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of pyruvic acid dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of pyruvic dehydrogenase activity" EXACT [GOC:TermGenie]
is_a: GO:0051354 ! negative regulation of oxidoreductase activity
is_a: GO:1904182 ! regulation of pyruvate dehydrogenase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004738 ! pyruvate dehydrogenase activity
relationship: negatively_regulates GO:0004738 ! pyruvate dehydrogenase activity
created_by: dph
creation_date: 2015-05-05T14:17:33Z

[Term]
id: GO:1904184
name: positive regulation of pyruvate dehydrogenase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pyruvate dehydrogenase activity." [GO_REF:0000059, GOC:dph, GOC:TermGenie, PMID:25525879]
synonym: "activation of pyruvate dehydrogenase activity" NARROW [GOC:TermGenie]
synonym: "activation of pyruvic acid dehydrogenase activity" NARROW [GOC:TermGenie]
synonym: "activation of pyruvic dehydrogenase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of pyruvic acid dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of pyruvic dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of pyruvate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of pyruvic acid dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of pyruvic dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of pyruvate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of pyruvic acid dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of pyruvic dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of pyruvate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of pyruvic acid dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of pyruvic dehydrogenase activity" EXACT [GOC:TermGenie]
is_a: GO:0051353 ! positive regulation of oxidoreductase activity
is_a: GO:1904182 ! regulation of pyruvate dehydrogenase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004738 ! pyruvate dehydrogenase activity
relationship: positively_regulates GO:0004738 ! pyruvate dehydrogenase activity
created_by: dph
creation_date: 2015-05-05T14:17:39Z

[Term]
id: GO:1904185
name: equatorial microtubule organizing center assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an equatorial microtubule organizing center." [GO_REF:0000079, GOC:TermGenie, PMID:15004232]
synonym: "EMTOC assembly" EXACT [GOC:TermGenie]
synonym: "EMTOC formation" EXACT [GOC:TermGenie]
synonym: "equatorial microtubule organising centre assembly" EXACT [GOC:TermGenie]
synonym: "equatorial microtubule organising centre formation" EXACT [GOC:TermGenie]
synonym: "equatorial microtubule organizing center formation" EXACT [GOC:TermGenie]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0031023 ! microtubule organizing center organization
created_by: mah
creation_date: 2015-05-05T14:24:30Z

[Term]
id: GO:1904186
name: post-anaphase microtubule array organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly ofa post-anaphase microtubule array." [GO_REF:000103, GOC:TermGenie, PMID:15004232]
synonym: "PAA organization" EXACT [GOC:TermGenie]
synonym: "post-anaphase array organization" EXACT [GOC:TermGenie]
synonym: "post-anaphase microtubule array organisation" EXACT []
is_a: GO:0016043 ! cellular component organization
created_by: mah
creation_date: 2015-05-05T14:40:16Z

[Term]
id: GO:1904187
name: regulation of transformation of host cell by virus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transformation of host cell by virus." [GO_REF:0000058, GOC:TermGenie, PMID:12200142]
synonym: "regulation of viral transformation" EXACT [GOC:TermGenie]
synonym: "regulation of viral transformation of host cell" EXACT [GOC:TermGenie]
is_a: GO:0050792 ! regulation of viral process
is_a: GO:0065008 ! regulation of biological quality
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019087 ! transformation of host cell by virus
relationship: regulates GO:0019087 ! transformation of host cell by virus
created_by: pga
creation_date: 2015-05-05T15:29:58Z

[Term]
id: GO:1904188
name: negative regulation of transformation of host cell by virus
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of transformation of host cell by virus." [GO_REF:0000058, GOC:TermGenie, PMID:12200142]
synonym: "down regulation of transformation of host cell by virus" EXACT [GOC:TermGenie]
synonym: "down regulation of viral transformation" EXACT [GOC:TermGenie]
synonym: "down regulation of viral transformation of host cell" EXACT [GOC:TermGenie]
synonym: "down-regulation of transformation of host cell by virus" EXACT [GOC:TermGenie]
synonym: "down-regulation of viral transformation" EXACT [GOC:TermGenie]
synonym: "down-regulation of viral transformation of host cell" EXACT [GOC:TermGenie]
synonym: "downregulation of transformation of host cell by virus" EXACT [GOC:TermGenie]
synonym: "downregulation of viral transformation" EXACT [GOC:TermGenie]
synonym: "downregulation of viral transformation of host cell" EXACT [GOC:TermGenie]
synonym: "inhibition of transformation of host cell by virus" NARROW [GOC:TermGenie]
synonym: "inhibition of viral transformation" NARROW [GOC:TermGenie]
synonym: "inhibition of viral transformation of host cell" NARROW [GOC:TermGenie]
synonym: "negative regulation of viral transformation" EXACT [GOC:TermGenie]
synonym: "negative regulation of viral transformation of host cell" EXACT [GOC:TermGenie]
is_a: GO:0048525 ! negative regulation of viral process
is_a: GO:1904187 ! regulation of transformation of host cell by virus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019087 ! transformation of host cell by virus
relationship: negatively_regulates GO:0019087 ! transformation of host cell by virus
created_by: pga
creation_date: 2015-05-05T15:30:04Z

[Term]
id: GO:1904189
name: positive regulation of transformation of host cell by virus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transformation of host cell by virus." [GO_REF:0000058, GOC:TermGenie, PMID:12200142]
synonym: "activation of transformation of host cell by virus" NARROW [GOC:TermGenie]
synonym: "activation of viral transformation" NARROW [GOC:TermGenie]
synonym: "activation of viral transformation of host cell" NARROW [GOC:TermGenie]
synonym: "positive regulation of viral transformation" EXACT [GOC:TermGenie]
synonym: "positive regulation of viral transformation of host cell" EXACT [GOC:TermGenie]
synonym: "up regulation of transformation of host cell by virus" EXACT [GOC:TermGenie]
synonym: "up regulation of viral transformation" EXACT [GOC:TermGenie]
synonym: "up regulation of viral transformation of host cell" EXACT [GOC:TermGenie]
synonym: "up-regulation of transformation of host cell by virus" EXACT [GOC:TermGenie]
synonym: "up-regulation of viral transformation" EXACT [GOC:TermGenie]
synonym: "up-regulation of viral transformation of host cell" EXACT [GOC:TermGenie]
synonym: "upregulation of transformation of host cell by virus" EXACT [GOC:TermGenie]
synonym: "upregulation of viral transformation" EXACT [GOC:TermGenie]
synonym: "upregulation of viral transformation of host cell" EXACT [GOC:TermGenie]
is_a: GO:0048524 ! positive regulation of viral process
is_a: GO:1904187 ! regulation of transformation of host cell by virus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0019087 ! transformation of host cell by virus
relationship: positively_regulates GO:0019087 ! transformation of host cell by virus
created_by: pga
creation_date: 2015-05-05T15:30:11Z

[Term]
id: GO:1904190
name: negative regulation of APC-fizzy related complex activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of APC-fizzy related complex activity." [GO_REF:0000059, GOC:TermGenie, GOC:vw]
synonym: "down regulation of APC-fizzy related complex activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of APC-fizzy related complex activity" EXACT [GOC:TermGenie]
synonym: "downregulation of APC-fizzy related complex activity" EXACT [GOC:TermGenie]
synonym: "inhibition of APC-fizzy related complex activity" NARROW [GOC:TermGenie]
is_a: GO:1903834 ! regulation of APC-fizzy related complex activity
is_a: GO:1904667 ! negative regulation of ubiquitin protein ligase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0090622 ! APC-fizzy related complex activity
relationship: negatively_regulates GO:0090622 ! APC-fizzy related complex activity
created_by: tb
creation_date: 2015-05-05T21:45:35Z

[Term]
id: GO:1904191
name: positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in meiotic nuclear division
namespace: biological_process
def: "Any positive regulation of cyclin-dependent protein serine/threonine kinase activity that is involved in meiotic nuclear division." [GO_REF:0000060, GOC:TermGenie, PMID:15791259]
synonym: "activation of cyclin-dependent protein kinase activity involved in meiotic nuclear division" NARROW [GOC:TermGenie]
synonym: "positive regulation of CDK activity involved in meiotic nuclear division" EXACT [GOC:TermGenie]
synonym: "positive regulation of cyclin-dependent protein kinase activity involved in meiosis" BROAD [GOC:TermGenie]
synonym: "stimulation of cyclin-dependent protein kinase activity involved in meiotic nuclear division" NARROW [GOC:TermGenie]
synonym: "up regulation of cyclin-dependent protein kinase activity involved in meiotic nuclear division" EXACT [GOC:TermGenie]
synonym: "up-regulation of cyclin-dependent protein kinase activity involved in meiotic nuclear division" EXACT [GOC:TermGenie]
synonym: "upregulation of cyclin-dependent protein kinase activity involved in meiotic nuclear division" EXACT [GOC:TermGenie]
is_a: GO:0040020 ! regulation of meiotic nuclear division
is_a: GO:0045737 ! positive regulation of cyclin-dependent protein serine/threonine kinase activity
intersection_of: GO:0045737 ! positive regulation of cyclin-dependent protein serine/threonine kinase activity
intersection_of: regulates GO:0007126 ! meiotic nuclear division
relationship: regulates GO:0007126 ! meiotic nuclear division
created_by: al
creation_date: 2015-05-06T14:48:52Z

[Term]
id: GO:1904192
name: regulation of cholangiocyte apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cholangiocyte apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24498161]
synonym: "regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:1904035 ! regulation of epithelial cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1902488 ! cholangiocyte apoptotic process
relationship: regulates GO:1902488 ! cholangiocyte apoptotic process
created_by: sl
creation_date: 2015-05-06T15:25:48Z

[Term]
id: GO:1904193
name: negative regulation of cholangiocyte apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cholangiocyte apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24498161]
synonym: "down regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of cholangiocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "down regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of cholangiocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of cholangiocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie]
synonym: "inhibition of cholangiocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of cholangiocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "inhibition of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of epithelial cell of bile duct apoptotic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:1904036 ! negative regulation of epithelial cell apoptotic process
is_a: GO:1904192 ! regulation of cholangiocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1902488 ! cholangiocyte apoptotic process
relationship: negatively_regulates GO:1902488 ! cholangiocyte apoptotic process
created_by: sl
creation_date: 2015-05-06T15:25:55Z

[Term]
id: GO:1904194
name: positive regulation of cholangiocyte apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cholangiocyte apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24498161]
synonym: "activation of cholangiocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of cholangiocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "activation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of epithelial cell of bile duct apoptotic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of cholangiocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of cholangiocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of cholangiocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:1904037 ! positive regulation of epithelial cell apoptotic process
is_a: GO:1904192 ! regulation of cholangiocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1902488 ! cholangiocyte apoptotic process
relationship: positively_regulates GO:1902488 ! cholangiocyte apoptotic process
created_by: sl
creation_date: 2015-05-06T15:26:00Z

[Term]
id: GO:1904195
name: regulation of granulosa cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of granulosa cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:22383759]
is_a: GO:0050678 ! regulation of epithelial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990739 ! granulosa cell proliferation
relationship: regulates GO:1990739 ! granulosa cell proliferation
created_by: sl
creation_date: 2015-05-07T17:02:25Z

[Term]
id: GO:1904196
name: negative regulation of granulosa cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of granulosa cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:22383759]
synonym: "down regulation of granulosa cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of granulosa cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of granulosa cell proliferation" EXACT [GOC:TermGenie]
synonym: "inhibition of granulosa cell proliferation" NARROW [GOC:TermGenie]
is_a: GO:0050680 ! negative regulation of epithelial cell proliferation
is_a: GO:1904195 ! regulation of granulosa cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990739 ! granulosa cell proliferation
relationship: negatively_regulates GO:1990739 ! granulosa cell proliferation
created_by: sl
creation_date: 2015-05-07T17:02:34Z

[Term]
id: GO:1904197
name: positive regulation of granulosa cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of granulosa cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:22383759]
synonym: "activation of granulosa cell proliferation" NARROW [GOC:TermGenie]
synonym: "up regulation of granulosa cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of granulosa cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of granulosa cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0050679 ! positive regulation of epithelial cell proliferation
is_a: GO:1904195 ! regulation of granulosa cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990739 ! granulosa cell proliferation
relationship: positively_regulates GO:1990739 ! granulosa cell proliferation
created_by: sl
creation_date: 2015-05-07T17:02:40Z

[Term]
id: GO:1904198
name: negative regulation of regulation of vascular smooth muscle cell membrane depolarization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of regulation of vascular smooth muscle cell membrane depolarization." [GO_REF:0000058, GOC:TermGenie, PMID:20826763]
synonym: "down regulation of regulation of vascular smooth muscle cell membrane depolarization" EXACT [GOC:TermGenie]
synonym: "down-regulation of regulation of vascular smooth muscle cell membrane depolarization" EXACT [GOC:TermGenie]
synonym: "downregulation of regulation of vascular smooth muscle cell membrane depolarization" EXACT [GOC:TermGenie]
synonym: "inhibition of regulation of vascular smooth muscle cell membrane depolarization" NARROW [GOC:TermGenie]
is_a: GO:1904180 ! negative regulation of membrane depolarization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990736 ! regulation of vascular smooth muscle cell membrane depolarization
relationship: negatively_regulates GO:1990736 ! regulation of vascular smooth muscle cell membrane depolarization
created_by: sl
creation_date: 2015-05-07T17:16:44Z

[Term]
id: GO:1904199
name: positive regulation of regulation of vascular smooth muscle cell membrane depolarization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of regulation of vascular smooth muscle cell membrane depolarization." [GO_REF:0000058, GOC:TermGenie, PMID:20826763]
synonym: "activation of regulation of vascular smooth muscle cell membrane depolarization" NARROW [GOC:TermGenie]
synonym: "up regulation of regulation of vascular smooth muscle cell membrane depolarization" EXACT [GOC:TermGenie]
synonym: "up-regulation of regulation of vascular smooth muscle cell membrane depolarization" EXACT [GOC:TermGenie]
synonym: "upregulation of regulation of vascular smooth muscle cell membrane depolarization" EXACT [GOC:TermGenie]
is_a: GO:1904181 ! positive regulation of membrane depolarization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990736 ! regulation of vascular smooth muscle cell membrane depolarization
relationship: positively_regulates GO:1990736 ! regulation of vascular smooth muscle cell membrane depolarization
created_by: sl
creation_date: 2015-05-07T17:16:50Z

[Term]
id: GO:1904200
name: iodide transmembrane transport
namespace: biological_process
def: "The directed movement of iodide across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:20392814]
is_a: GO:0015705 ! iodide transport
is_a: GO:0098661 ! inorganic anion transmembrane transport
created_by: sl
creation_date: 2015-05-08T15:17:19Z

[Term]
id: GO:1904201
name: regulation of iodide transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of iodide transport." [GO_REF:0000058, GOC:TermGenie, PMID:20392814]
is_a: GO:0044070 ! regulation of anion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0015705 ! iodide transport
relationship: regulates GO:0015705 ! iodide transport
created_by: sl
creation_date: 2015-05-08T15:19:57Z

[Term]
id: GO:1904202
name: negative regulation of iodide transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of iodide transport." [GO_REF:0000058, GOC:TermGenie, PMID:20392814]
synonym: "down regulation of iodide transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of iodide transport" EXACT [GOC:TermGenie]
synonym: "downregulation of iodide transport" EXACT [GOC:TermGenie]
synonym: "inhibition of iodide transport" NARROW [GOC:TermGenie]
is_a: GO:1903792 ! negative regulation of anion transport
is_a: GO:1904201 ! regulation of iodide transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0015705 ! iodide transport
relationship: negatively_regulates GO:0015705 ! iodide transport
created_by: sl
creation_date: 2015-05-08T15:20:03Z

[Term]
id: GO:1904203
name: positive regulation of iodide transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of iodide transport." [GO_REF:0000058, GOC:TermGenie, PMID:20392814]
synonym: "activation of iodide transport" NARROW [GOC:TermGenie]
synonym: "up regulation of iodide transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of iodide transport" EXACT [GOC:TermGenie]
synonym: "upregulation of iodide transport" EXACT [GOC:TermGenie]
is_a: GO:1903793 ! positive regulation of anion transport
is_a: GO:1904201 ! regulation of iodide transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0015705 ! iodide transport
relationship: positively_regulates GO:0015705 ! iodide transport
created_by: sl
creation_date: 2015-05-08T15:20:09Z

[Term]
id: GO:1904204
name: regulation of skeletal muscle hypertrophy
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle hypertrophy." [GO_REF:0000058, GOC:TermGenie, PMID:23470307]
is_a: GO:0014733 ! regulation of skeletal muscle adaptation
is_a: GO:0014743 ! regulation of muscle hypertrophy
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0014734 ! skeletal muscle hypertrophy
relationship: regulates GO:0014734 ! skeletal muscle hypertrophy
created_by: sl
creation_date: 2015-05-08T17:38:13Z

[Term]
id: GO:1904205
name: negative regulation of skeletal muscle hypertrophy
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle hypertrophy." [GO_REF:0000058, GOC:TermGenie, PMID:23470307]
synonym: "down regulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie]
synonym: "down-regulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie]
synonym: "downregulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie]
synonym: "inhibition of skeletal muscle hypertrophy" NARROW [GOC:TermGenie]
is_a: GO:0014741 ! negative regulation of muscle hypertrophy
is_a: GO:0014745 ! negative regulation of muscle adaptation
is_a: GO:1904204 ! regulation of skeletal muscle hypertrophy
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0014734 ! skeletal muscle hypertrophy
relationship: negatively_regulates GO:0014734 ! skeletal muscle hypertrophy
created_by: sl
creation_date: 2015-05-08T17:38:19Z

[Term]
id: GO:1904206
name: positive regulation of skeletal muscle hypertrophy
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of skeletal muscle hypertrophy." [GO_REF:0000058, GOC:TermGenie, PMID:23470307]
synonym: "activation of skeletal muscle hypertrophy" NARROW [GOC:TermGenie]
synonym: "up regulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie]
synonym: "up-regulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie]
synonym: "upregulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie]
is_a: GO:0014742 ! positive regulation of muscle hypertrophy
is_a: GO:0014744 ! positive regulation of muscle adaptation
is_a: GO:1904204 ! regulation of skeletal muscle hypertrophy
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0014734 ! skeletal muscle hypertrophy
relationship: positively_regulates GO:0014734 ! skeletal muscle hypertrophy
created_by: sl
creation_date: 2015-05-08T17:38:25Z

[Term]
id: GO:1904207
name: regulation of chemokine (C-C motif) ligand 2 secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chemokine (C-C motif) ligand 2 secretion." [GO_REF:0000058, GOC:TermGenie, PMID:24260297]
synonym: "regulation of CCL2 secretion" EXACT [GOC:TermGenie]
is_a: GO:0090196 ! regulation of chemokine secretion
is_a: GO:2000341 ! regulation of chemokine (C-X-C motif) ligand 2 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035926 ! chemokine (C-C motif) ligand 2 secretion
relationship: regulates GO:0035926 ! chemokine (C-C motif) ligand 2 secretion
created_by: sl
creation_date: 2015-05-11T16:47:07Z

[Term]
id: GO:1904208
name: negative regulation of chemokine (C-C motif) ligand 2 secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chemokine (C-C motif) ligand 2 secretion." [GO_REF:0000058, GOC:TermGenie, PMID:24260297]
synonym: "down regulation of CCL2 secretion" EXACT [GOC:TermGenie]
synonym: "down regulation of chemokine (C-C motif) ligand 2 secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of CCL2 secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of chemokine (C-C motif) ligand 2 secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of CCL2 secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of chemokine (C-C motif) ligand 2 secretion" EXACT [GOC:TermGenie]
synonym: "inhibition of CCL2 secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of chemokine (C-C motif) ligand 2 secretion" NARROW [GOC:TermGenie]
synonym: "negative regulation of CCL2 secretion" EXACT [GOC:TermGenie]
is_a: GO:0090198 ! negative regulation of chemokine secretion
is_a: GO:1904207 ! regulation of chemokine (C-C motif) ligand 2 secretion
is_a: GO:2000342 ! negative regulation of chemokine (C-X-C motif) ligand 2 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035926 ! chemokine (C-C motif) ligand 2 secretion
relationship: negatively_regulates GO:0035926 ! chemokine (C-C motif) ligand 2 secretion
created_by: sl
creation_date: 2015-05-11T16:47:13Z

[Term]
id: GO:1904209
name: positive regulation of chemokine (C-C motif) ligand 2 secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chemokine (C-C motif) ligand 2 secretion." [GO_REF:0000058, GOC:TermGenie, PMID:24260297]
synonym: "activation of CCL2 secretion" NARROW [GOC:TermGenie]
synonym: "activation of chemokine (C-C motif) ligand 2 secretion" NARROW [GOC:TermGenie]
synonym: "positive regulation of CCL2 secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of CCL2 secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of chemokine (C-C motif) ligand 2 secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of CCL2 secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of chemokine (C-C motif) ligand 2 secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of CCL2 secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of chemokine (C-C motif) ligand 2 secretion" EXACT [GOC:TermGenie]
is_a: GO:0090197 ! positive regulation of chemokine secretion
is_a: GO:1904207 ! regulation of chemokine (C-C motif) ligand 2 secretion
is_a: GO:2000343 ! positive regulation of chemokine (C-X-C motif) ligand 2 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035926 ! chemokine (C-C motif) ligand 2 secretion
relationship: positively_regulates GO:0035926 ! chemokine (C-C motif) ligand 2 secretion
created_by: sl
creation_date: 2015-05-11T16:47:19Z

[Term]
id: GO:1904210
name: VCP-NPL4-UFD1 AAA ATPase complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a VCP-NPL4-UFD1 AAA ATPase complex." [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:17000876]
synonym: "Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly" NARROW [GOC:TermGenie]
synonym: "Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation" NARROW [GOC:TermGenie]
synonym: "p97-Ufd1-Npl4 complex assembly" EXACT [GOC:TermGenie]
synonym: "p97-Ufd1-Npl4 complex formation" EXACT [GOC:TermGenie]
synonym: "VCP-NPL4-UFD1 AAA ATPase complex formation" EXACT [GOC:TermGenie]
is_a: GO:0006461 ! protein complex assembly
created_by: bf
creation_date: 2015-05-14T10:34:36Z

[Term]
id: GO:1904211
name: membrane protein proteolysis involved in retrograde protein transport, ER to cytosol
namespace: biological_process
def: "Any membrane protein proteolysis that is involved in retrograde protein transport, ER to cytosol." [GO_REF:0000060, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22795130]
synonym: "intramembrane cleavage of ERAD substrate" BROAD [PMID:22795130]
synonym: "intramembrane proteolysis involved in ERAD" EXACT [PMID:22795130]
synonym: "membrane protein proteolysis involved in protein dislocation from ER" EXACT [GOC:TermGenie]
synonym: "membrane protein proteolysis involved in protein retrotranslocation, ER to cytosol" EXACT [GOC:TermGenie]
synonym: "membrane protein proteolysis involved in retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie]
is_a: GO:0033619 ! membrane protein proteolysis
intersection_of: GO:0033619 ! membrane protein proteolysis
intersection_of: part_of GO:0030970 ! retrograde protein transport, ER to cytosol
relationship: part_of GO:0030970 ! retrograde protein transport, ER to cytosol
created_by: bf
creation_date: 2015-05-14T15:26:44Z

[Term]
id: GO:1904212
name: regulation of iodide transmembrane transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of iodide transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:20392814]
is_a: GO:1903795 ! regulation of inorganic anion transmembrane transport
is_a: GO:1904201 ! regulation of iodide transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1904200 ! iodide transmembrane transport
relationship: regulates GO:1904200 ! iodide transmembrane transport
created_by: sl
creation_date: 2015-05-14T19:00:02Z

[Term]
id: GO:1904213
name: negative regulation of iodide transmembrane transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of iodide transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:20392814]
synonym: "down regulation of iodide transmembrane transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of iodide transmembrane transport" EXACT [GOC:TermGenie]
synonym: "downregulation of iodide transmembrane transport" EXACT [GOC:TermGenie]
synonym: "inhibition of iodide transmembrane transport" NARROW [GOC:TermGenie]
is_a: GO:1903796 ! negative regulation of inorganic anion transmembrane transport
is_a: GO:1904202 ! negative regulation of iodide transport
is_a: GO:1904212 ! regulation of iodide transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1904200 ! iodide transmembrane transport
relationship: negatively_regulates GO:1904200 ! iodide transmembrane transport
created_by: sl
creation_date: 2015-05-14T19:00:08Z

[Term]
id: GO:1904214
name: positive regulation of iodide transmembrane transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of iodide transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:20392814]
synonym: "activation of iodide transmembrane transport" NARROW [GOC:TermGenie]
synonym: "up regulation of iodide transmembrane transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of iodide transmembrane transport" EXACT [GOC:TermGenie]
synonym: "upregulation of iodide transmembrane transport" EXACT [GOC:TermGenie]
is_a: GO:1903797 ! positive regulation of inorganic anion transmembrane transport
is_a: GO:1904203 ! positive regulation of iodide transport
is_a: GO:1904212 ! regulation of iodide transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1904200 ! iodide transmembrane transport
relationship: positively_regulates GO:1904200 ! iodide transmembrane transport
created_by: sl
creation_date: 2015-05-14T19:00:14Z

[Term]
id: GO:1904215
name: regulation of protein import into chloroplast stroma
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein import into chloroplast stroma." [GO_REF:0000058, GOC:TermGenie, PMID:25901327]
synonym: "regulation of chloroplast stroma protein import" EXACT [GOC:TermGenie]
synonym: "regulation of protein transport into chloroplast stroma" EXACT [GOC:TermGenie]
is_a: GO:0034762 ! regulation of transmembrane transport
is_a: GO:1903533 ! regulation of protein targeting
is_a: GO:1903649 ! regulation of cytoplasmic transport
is_a: GO:1904589 ! regulation of protein import
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045037 ! protein import into chloroplast stroma
relationship: regulates GO:0045037 ! protein import into chloroplast stroma
created_by: tb
creation_date: 2015-05-15T00:47:48Z

[Term]
id: GO:1904216
name: positive regulation of protein import into chloroplast stroma
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein import into chloroplast stroma." [GO_REF:0000058, GOC:TermGenie, PMID:25901327]
synonym: "activation of chloroplast stroma protein import" NARROW [GOC:TermGenie]
synonym: "activation of protein import into chloroplast stroma" NARROW [GOC:TermGenie]
synonym: "activation of protein transport into chloroplast stroma" NARROW [GOC:TermGenie]
synonym: "positive regulation of chloroplast stroma protein import" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein transport into chloroplast stroma" EXACT [GOC:TermGenie]
synonym: "up regulation of chloroplast stroma protein import" EXACT [GOC:TermGenie]
synonym: "up regulation of protein import into chloroplast stroma" EXACT [GOC:TermGenie]
synonym: "up regulation of protein transport into chloroplast stroma" EXACT [GOC:TermGenie]
synonym: "up-regulation of chloroplast stroma protein import" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein import into chloroplast stroma" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein transport into chloroplast stroma" EXACT [GOC:TermGenie]
synonym: "upregulation of chloroplast stroma protein import" EXACT [GOC:TermGenie]
synonym: "upregulation of protein import into chloroplast stroma" EXACT [GOC:TermGenie]
synonym: "upregulation of protein transport into chloroplast stroma" EXACT [GOC:TermGenie]
is_a: GO:0034764 ! positive regulation of transmembrane transport
is_a: GO:0090316 ! positive regulation of intracellular protein transport
is_a: GO:1903651 ! positive regulation of cytoplasmic transport
is_a: GO:1904215 ! regulation of protein import into chloroplast stroma
is_a: GO:1904591 ! positive regulation of protein import
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045037 ! protein import into chloroplast stroma
relationship: positively_regulates GO:0045037 ! protein import into chloroplast stroma
created_by: tb
creation_date: 2015-05-15T00:47:55Z

[Term]
id: GO:1904217
name: regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of CDP-diacylglycerol-serine O-phosphatidyltransferase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16120614]
comment: Serinc proteins form a complex with serine and sphingolipid biosynthesis enzymes and regulates their activity through regulation of availability of the substrate
synonym: "regulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of CDP-diglyceride-L-serine phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of CDP-diglyceride:serine phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of CDP-diglycerine-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of CDPdiglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of phosphatidylserine synthase activity" EXACT [GOC:TermGenie]
synonym: "regulation of phosphatidylserine synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of PS synthase activity" EXACT [GOC:TermGenie]
synonym: "regulation of serine exchange enzyme" BROAD [GOC:TermGenie]
is_a: GO:0051338 ! regulation of transferase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003882 ! CDP-diacylglycerol-serine O-phosphatidyltransferase activity
relationship: regulates GO:0003882 ! CDP-diacylglycerol-serine O-phosphatidyltransferase activity
created_by: rl
creation_date: 2015-05-15T08:18:23Z

[Term]
id: GO:1904218
name: negative regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of CDP-diacylglycerol-serine O-phosphatidyltransferase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16120614]
comment: Serinc proteins form a complex with serine and sphingolipid biosynthesis enzymes and regulates their activity through regulation of availability of the substrate
synonym: "down regulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of CDP-diglyceride-L-serine phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of CDP-diglyceride:serine phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of CDP-diglycerine-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of CDPdiglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphatidylserine synthase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of phosphatidylserine synthetase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of PS synthase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of CDP-diglyceride-L-serine phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of CDP-diglyceride:serine phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of CDP-diglycerine-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of CDPdiglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphatidylserine synthase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of phosphatidylserine synthetase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of PS synthase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of CDP-diglyceride-L-serine phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of CDP-diglyceride:serine phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of CDP-diglycerine-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of CDPdiglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphatidylserine synthase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of phosphatidylserine synthetase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of PS synthase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of CDP-diacylglycerol-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of CDP-diglyceride-L-serine phosphatidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of CDP-diglyceride:serine phosphatidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of CDP-diglycerine-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of CDPdiacylglycerol-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of CDPdiglyceride-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of phosphatidylserine synthase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of phosphatidylserine synthetase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of PS synthase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of CDP-diglyceride-L-serine phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of CDP-diglyceride:serine phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of CDP-diglycerine-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of CDPdiglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphatidylserine synthase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of phosphatidylserine synthetase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of PS synthase activity" EXACT [GOC:TermGenie]
is_a: GO:0051348 ! negative regulation of transferase activity
is_a: GO:1904217 ! regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003882 ! CDP-diacylglycerol-serine O-phosphatidyltransferase activity
relationship: negatively_regulates GO:0003882 ! CDP-diacylglycerol-serine O-phosphatidyltransferase activity
created_by: rl
creation_date: 2015-05-15T08:18:29Z

[Term]
id: GO:1904219
name: positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of CDP-diacylglycerol-serine O-phosphatidyltransferase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16120614]
comment: Serinc proteins form a complex with serine and sphingolipid biosynthesis enzymes and regulates their activity through regulation of availability of the substrate
synonym: "activation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of CDP-diglyceride-L-serine phosphatidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of CDP-diglyceride:serine phosphatidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of CDP-diglycerine-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of CDPdiglyceride-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of phosphatidylserine synthase activity" NARROW [GOC:TermGenie]
synonym: "activation of phosphatidylserine synthetase activity" NARROW [GOC:TermGenie]
synonym: "activation of PS synthase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of CDP-diglyceride-L-serine phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of CDP-diglyceride:serine phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of CDP-diglycerine-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of CDPdiglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphatidylserine synthase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of phosphatidylserine synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of PS synthase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of CDP-diglyceride-L-serine phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of CDP-diglyceride:serine phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of CDP-diglycerine-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of CDPdiglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphatidylserine synthase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of phosphatidylserine synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of PS synthase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of CDP-diglyceride-L-serine phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of CDP-diglyceride:serine phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of CDP-diglycerine-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of CDPdiglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphatidylserine synthase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of phosphatidylserine synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of PS synthase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of CDP-diglyceride-L-serine phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of CDP-diglyceride:serine phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of CDP-diglycerine-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of CDPdiglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphatidylserine synthase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of phosphatidylserine synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of PS synthase activity" EXACT [GOC:TermGenie]
is_a: GO:0051347 ! positive regulation of transferase activity
is_a: GO:1904217 ! regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003882 ! CDP-diacylglycerol-serine O-phosphatidyltransferase activity
relationship: positively_regulates GO:0003882 ! CDP-diacylglycerol-serine O-phosphatidyltransferase activity
created_by: rl
creation_date: 2015-05-15T08:18:35Z

[Term]
id: GO:1904220
name: regulation of serine C-palmitoyltransferase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of serine C-palmitoyltransferase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16120614]
comment: Serinc proteins form a complex with serine and sphingolipid biosynthesis enzymes and regulates their activity through regulation of the substrate availability
synonym: "regulation of 3-oxosphinganine synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of acyl-CoA:serine C-2 acyltransferase decarboxylating" RELATED [GOC:TermGenie]
synonym: "regulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity" EXACT [GOC:TermGenie]
synonym: "regulation of serine palmitoyltransferase" BROAD [GOC:TermGenie]
synonym: "regulation of SPT" RELATED [GOC:TermGenie]
is_a: GO:0051338 ! regulation of transferase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004758 ! serine C-palmitoyltransferase activity
relationship: regulates GO:0004758 ! serine C-palmitoyltransferase activity
created_by: rl
creation_date: 2015-05-15T08:27:33Z

[Term]
id: GO:1904221
name: negative regulation of serine C-palmitoyltransferase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of serine C-palmitoyltransferase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16120614]
comment: Serinc proteins form a complex with serine and sphingolipid biosynthesis enzymes and regulates their activity through regulation of the substrate availability
synonym: "down regulation of 3-oxosphinganine synthetase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of acyl-CoA:serine C-2 acyltransferase decarboxylating" RELATED [GOC:TermGenie]
synonym: "down regulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity" EXACT [GOC:TermGenie]
synonym: "down regulation of serine C-palmitoyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of SPT" RELATED [GOC:TermGenie]
synonym: "down-regulation of 3-oxosphinganine synthetase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of acyl-CoA:serine C-2 acyltransferase decarboxylating" RELATED [GOC:TermGenie]
synonym: "down-regulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of serine C-palmitoyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of SPT" RELATED [GOC:TermGenie]
synonym: "downregulation of 3-oxosphinganine synthetase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of acyl-CoA:serine C-2 acyltransferase decarboxylating" RELATED [GOC:TermGenie]
synonym: "downregulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity" EXACT [GOC:TermGenie]
synonym: "downregulation of serine C-palmitoyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of SPT" RELATED [GOC:TermGenie]
synonym: "inhibition of 3-oxosphinganine synthetase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of acyl-CoA:serine C-2 acyltransferase decarboxylating" RELATED [GOC:TermGenie]
synonym: "inhibition of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity" NARROW [GOC:TermGenie]
synonym: "inhibition of serine C-palmitoyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of SPT" RELATED [GOC:TermGenie]
synonym: "negative regulation of 3-oxosphinganine synthetase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of acyl-CoA:serine C-2 acyltransferase decarboxylating" RELATED [GOC:TermGenie]
synonym: "negative regulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of SPT" RELATED [GOC:TermGenie]
is_a: GO:0051348 ! negative regulation of transferase activity
is_a: GO:1904220 ! regulation of serine C-palmitoyltransferase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004758 ! serine C-palmitoyltransferase activity
relationship: negatively_regulates GO:0004758 ! serine C-palmitoyltransferase activity
created_by: rl
creation_date: 2015-05-15T08:27:39Z

[Term]
id: GO:1904222
name: positive regulation of serine C-palmitoyltransferase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of serine C-palmitoyltransferase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16120614]
comment: Serinc proteins form a complex with serine and sphingolipid biosynthesis enzymes and regulates their activity through regulation of the substrate availability
synonym: "activation of 3-oxosphinganine synthetase activity" NARROW [GOC:TermGenie]
synonym: "activation of acyl-CoA:serine C-2 acyltransferase decarboxylating" RELATED [GOC:TermGenie]
synonym: "activation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity" NARROW [GOC:TermGenie]
synonym: "activation of serine C-palmitoyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of SPT" RELATED [GOC:TermGenie]
synonym: "positive regulation of 3-oxosphinganine synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of acyl-CoA:serine C-2 acyltransferase decarboxylating" RELATED [GOC:TermGenie]
synonym: "positive regulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of SPT" RELATED [GOC:TermGenie]
synonym: "up regulation of 3-oxosphinganine synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of acyl-CoA:serine C-2 acyltransferase decarboxylating" RELATED [GOC:TermGenie]
synonym: "up regulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity" EXACT [GOC:TermGenie]
synonym: "up regulation of serine C-palmitoyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of SPT" RELATED [GOC:TermGenie]
synonym: "up-regulation of 3-oxosphinganine synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of acyl-CoA:serine C-2 acyltransferase decarboxylating" RELATED [GOC:TermGenie]
synonym: "up-regulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of serine C-palmitoyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of SPT" RELATED [GOC:TermGenie]
synonym: "upregulation of 3-oxosphinganine synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of acyl-CoA:serine C-2 acyltransferase decarboxylating" RELATED [GOC:TermGenie]
synonym: "upregulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity" EXACT [GOC:TermGenie]
synonym: "upregulation of serine C-palmitoyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of SPT" RELATED [GOC:TermGenie]
is_a: GO:0051347 ! positive regulation of transferase activity
is_a: GO:1904220 ! regulation of serine C-palmitoyltransferase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004758 ! serine C-palmitoyltransferase activity
relationship: positively_regulates GO:0004758 ! serine C-palmitoyltransferase activity
created_by: rl
creation_date: 2015-05-15T08:27:45Z

[Term]
id: GO:1904223
name: regulation of glucuronosyltransferase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glucuronosyltransferase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20610558]
comment: i2 UDP-glucuronosyltransferase splice species alter glucuronidation activity of i1 UDP-glucuronosyltransferase splice species
synonym: "regulation of 1-naphthol glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of 1-naphthol-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of 17-OH steroid UDPGT activity" NARROW [GOC:TermGenie]
synonym: "regulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of 3-OH androgenic UDPGT activity" NARROW [GOC:TermGenie]
synonym: "regulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of 4-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of 4-nitrophenol UDPGT activity" NARROW [GOC:TermGenie]
synonym: "regulation of bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of bilirubin monoglucuronide glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of bilirubin UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of bilirubin UDPGT activity" NARROW [GOC:TermGenie]
synonym: "regulation of bilirubin uridine diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of ciramadol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of estriol UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of estrone UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of GT activity" EXACT [GOC:TermGenie]
synonym: "regulation of morphine glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of p-hydroxybiphenyl UDP glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of p-nitrophenol UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of p-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of p-nitrophenylglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of p-phenylphenol glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of phenyl-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of PNP-UDPGT" RELATED [GOC:TermGenie]
synonym: "regulation of pnp-UDPGT activity" NARROW [GOC:TermGenie]
synonym: "regulation of UDP glucuronate-estradiol-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of UDP glucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of UDP glucuronic acid transferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of UDP glucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of UDP glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)" EXACT [GOC:TermGenie]
synonym: "regulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of UDP-glucuronate-bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of UDP-glucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of UDP-glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of UDPGA transferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of UDPGA-glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity" NARROW [GOC:TermGenie]
synonym: "regulation of UDPGT activity" EXACT [GOC:TermGenie]
synonym: "regulation of uridine 5'-diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of uridine diphosphate glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "regulation of uridine diphosphoglucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of uridine diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie]
is_a: GO:0051338 ! regulation of transferase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0015020 ! glucuronosyltransferase activity
relationship: regulates GO:0015020 ! glucuronosyltransferase activity
created_by: rl
creation_date: 2015-05-15T08:44:20Z

[Term]
id: GO:1904224
name: negative regulation of glucuronosyltransferase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glucuronosyltransferase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20610558]
comment: i2 UDP-glucuronosyltransferase splice species alter glucuronidation activity of i1 UDP-glucuronosyltransferase splice species
synonym: "down regulation of 1-naphthol glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of 1-naphthol-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of 17-OH steroid UDPGT activity" NARROW [GOC:TermGenie]
synonym: "down regulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of 3-OH androgenic UDPGT activity" NARROW [GOC:TermGenie]
synonym: "down regulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of 4-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of 4-nitrophenol UDPGT activity" NARROW [GOC:TermGenie]
synonym: "down regulation of bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of bilirubin monoglucuronide glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of bilirubin UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of bilirubin UDPGT activity" NARROW [GOC:TermGenie]
synonym: "down regulation of bilirubin uridine diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of ciramadol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of estriol UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of estrone UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of glucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of GT activity" EXACT [GOC:TermGenie]
synonym: "down regulation of morphine glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of p-hydroxybiphenyl UDP glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of p-nitrophenol UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of p-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of p-nitrophenylglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of p-phenylphenol glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of phenyl-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of PNP-UDPGT" RELATED [GOC:TermGenie]
synonym: "down regulation of pnp-UDPGT activity" NARROW [GOC:TermGenie]
synonym: "down regulation of UDP glucuronate-estradiol-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of UDP glucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of UDP glucuronic acid transferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of UDP glucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of UDP glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)" EXACT [GOC:TermGenie]
synonym: "down regulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of UDP-glucuronate-bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of UDP-glucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of UDP-glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of UDPGA transferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of UDPGA-glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity" NARROW [GOC:TermGenie]
synonym: "down regulation of UDPGT activity" EXACT [GOC:TermGenie]
synonym: "down regulation of uridine 5'-diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of uridine diphosphate glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of uridine diphosphoglucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of uridine diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of 1-naphthol glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of 1-naphthol-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of 17-OH steroid UDPGT activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of 3-OH androgenic UDPGT activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of 4-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of 4-nitrophenol UDPGT activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of bilirubin monoglucuronide glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of bilirubin UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of bilirubin UDPGT activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of bilirubin uridine diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of ciramadol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of estriol UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of estrone UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of glucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of GT activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of morphine glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of p-hydroxybiphenyl UDP glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of p-nitrophenol UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of p-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of p-nitrophenylglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of p-phenylphenol glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of phenyl-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of PNP-UDPGT" RELATED [GOC:TermGenie]
synonym: "down-regulation of pnp-UDPGT activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of UDP glucuronate-estradiol-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of UDP glucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of UDP glucuronic acid transferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of UDP glucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of UDP glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)" EXACT [GOC:TermGenie]
synonym: "down-regulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of UDP-glucuronate-bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of UDP-glucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of UDP-glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of UDPGA transferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of UDPGA-glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of UDPGT activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of uridine 5'-diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of uridine diphosphate glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of uridine diphosphoglucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of uridine diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of 1-naphthol glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of 1-naphthol-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of 17-OH steroid UDPGT activity" NARROW [GOC:TermGenie]
synonym: "downregulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of 3-OH androgenic UDPGT activity" NARROW [GOC:TermGenie]
synonym: "downregulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of 4-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of 4-nitrophenol UDPGT activity" NARROW [GOC:TermGenie]
synonym: "downregulation of bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of bilirubin monoglucuronide glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of bilirubin UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of bilirubin UDPGT activity" NARROW [GOC:TermGenie]
synonym: "downregulation of bilirubin uridine diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of ciramadol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of estriol UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of estrone UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of glucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of GT activity" EXACT [GOC:TermGenie]
synonym: "downregulation of morphine glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of p-hydroxybiphenyl UDP glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of p-nitrophenol UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of p-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of p-nitrophenylglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of p-phenylphenol glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of phenyl-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of PNP-UDPGT" RELATED [GOC:TermGenie]
synonym: "downregulation of pnp-UDPGT activity" NARROW [GOC:TermGenie]
synonym: "downregulation of UDP glucuronate-estradiol-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of UDP glucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of UDP glucuronic acid transferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of UDP glucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of UDP glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)" EXACT [GOC:TermGenie]
synonym: "downregulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of UDP-glucuronate-bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of UDP-glucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of UDP-glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of UDPGA transferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of UDPGA-glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity" NARROW [GOC:TermGenie]
synonym: "downregulation of UDPGT activity" EXACT [GOC:TermGenie]
synonym: "downregulation of uridine 5'-diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of uridine diphosphate glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of uridine diphosphoglucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of uridine diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of 1-naphthol glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of 1-naphthol-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of 17-OH steroid UDPGT activity" NARROW [GOC:TermGenie]
synonym: "inhibition of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of 3-OH androgenic UDPGT activity" NARROW [GOC:TermGenie]
synonym: "inhibition of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of 4-methylumbelliferone UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of 4-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of 4-nitrophenol UDPGT activity" NARROW [GOC:TermGenie]
synonym: "inhibition of bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of bilirubin monoglucuronide glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of bilirubin UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of bilirubin UDPGT activity" NARROW [GOC:TermGenie]
synonym: "inhibition of bilirubin uridine diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of ciramadol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of estriol UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of estrone UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of GT activity" NARROW [GOC:TermGenie]
synonym: "inhibition of morphine glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of p-hydroxybiphenyl UDP glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of p-nitrophenol UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of p-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of p-nitrophenylglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of p-phenylphenol glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of phenyl-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of PNP-UDPGT" RELATED [GOC:TermGenie]
synonym: "inhibition of pnp-UDPGT activity" NARROW [GOC:TermGenie]
synonym: "inhibition of UDP glucuronate-estradiol-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of UDP glucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of UDP glucuronic acid transferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of UDP glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of UDP glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)" NARROW [GOC:TermGenie]
synonym: "inhibition of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of UDP-glucuronate-bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of UDPGA transferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of UDPGA-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity" NARROW [GOC:TermGenie]
synonym: "inhibition of UDPGT activity" NARROW [GOC:TermGenie]
synonym: "inhibition of uridine 5'-diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of uridine diphosphate glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of uridine diphosphoglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of uridine diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of 1-naphthol glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of 1-naphthol-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of 17-OH steroid UDPGT activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of 3-OH androgenic UDPGT activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of 4-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of 4-nitrophenol UDPGT activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of bilirubin monoglucuronide glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of bilirubin UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of bilirubin UDPGT activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of bilirubin uridine diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of ciramadol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of estriol UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of estrone UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of GT activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of morphine glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of p-hydroxybiphenyl UDP glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of p-nitrophenol UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of p-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of p-nitrophenylglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of p-phenylphenol glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of phenyl-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of PNP-UDPGT" RELATED [GOC:TermGenie]
synonym: "negative regulation of pnp-UDPGT activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of UDP glucuronate-estradiol-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of UDP glucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of UDP glucuronic acid transferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of UDP glucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of UDP glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)" EXACT [GOC:TermGenie]
synonym: "negative regulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of UDP-glucuronate-bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of UDP-glucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of UDP-glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of UDPGA transferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of UDPGA-glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of UDPGT activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of uridine 5'-diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of uridine diphosphate glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of uridine diphosphoglucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of uridine diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie]
is_a: GO:0051348 ! negative regulation of transferase activity
is_a: GO:1904223 ! regulation of glucuronosyltransferase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0015020 ! glucuronosyltransferase activity
relationship: negatively_regulates GO:0015020 ! glucuronosyltransferase activity
created_by: rl
creation_date: 2015-05-15T08:44:26Z

[Term]
id: GO:1904225
name: positive regulation of glucuronosyltransferase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glucuronosyltransferase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20610558]
comment: i2 UDP-glucuronosyltransferase splice species alter glucuronidation activity of i1 UDP-glucuronosyltransferase splice species
synonym: "activation of 1-naphthol glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of 1-naphthol-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of 17-OH steroid UDPGT activity" NARROW [GOC:TermGenie]
synonym: "activation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of 3-OH androgenic UDPGT activity" NARROW [GOC:TermGenie]
synonym: "activation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of 4-methylumbelliferone UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of 4-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of 4-nitrophenol UDPGT activity" NARROW [GOC:TermGenie]
synonym: "activation of bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of bilirubin monoglucuronide glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of bilirubin UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of bilirubin UDPGT activity" NARROW [GOC:TermGenie]
synonym: "activation of bilirubin uridine diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of ciramadol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of estriol UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of estrone UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of GT activity" NARROW [GOC:TermGenie]
synonym: "activation of morphine glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of p-hydroxybiphenyl UDP glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of p-nitrophenol UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of p-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of p-nitrophenylglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of p-phenylphenol glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of phenyl-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of PNP-UDPGT" RELATED [GOC:TermGenie]
synonym: "activation of pnp-UDPGT activity" NARROW [GOC:TermGenie]
synonym: "activation of UDP glucuronate-estradiol-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of UDP glucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of UDP glucuronic acid transferase activity" NARROW [GOC:TermGenie]
synonym: "activation of UDP glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of UDP glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)" NARROW [GOC:TermGenie]
synonym: "activation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of UDP-glucuronate-bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of UDPGA transferase activity" NARROW [GOC:TermGenie]
synonym: "activation of UDPGA-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity" NARROW [GOC:TermGenie]
synonym: "activation of UDPGT activity" NARROW [GOC:TermGenie]
synonym: "activation of uridine 5'-diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of uridine diphosphate glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of uridine diphosphoglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of uridine diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of 1-naphthol glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of 1-naphthol-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of 17-OH steroid UDPGT activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of 3-OH androgenic UDPGT activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of 4-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of 4-nitrophenol UDPGT activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of bilirubin monoglucuronide glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of bilirubin UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of bilirubin UDPGT activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of bilirubin uridine diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of ciramadol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of estriol UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of estrone UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of GT activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of morphine glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of p-hydroxybiphenyl UDP glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of p-nitrophenol UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of p-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of p-nitrophenylglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of p-phenylphenol glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of phenyl-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of PNP-UDPGT" RELATED [GOC:TermGenie]
synonym: "positive regulation of pnp-UDPGT activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of UDP glucuronate-estradiol-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of UDP glucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of UDP glucuronic acid transferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of UDP glucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of UDP glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)" EXACT [GOC:TermGenie]
synonym: "positive regulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of UDP-glucuronate-bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of UDP-glucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of UDP-glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of UDPGA transferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of UDPGA-glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of UDPGT activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of uridine 5'-diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of uridine diphosphate glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of uridine diphosphoglucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of uridine diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of 1-naphthol glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of 1-naphthol-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of 17-OH steroid UDPGT activity" NARROW [GOC:TermGenie]
synonym: "up regulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of 3-OH androgenic UDPGT activity" NARROW [GOC:TermGenie]
synonym: "up regulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of 4-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of 4-nitrophenol UDPGT activity" NARROW [GOC:TermGenie]
synonym: "up regulation of bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of bilirubin monoglucuronide glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of bilirubin UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of bilirubin UDPGT activity" NARROW [GOC:TermGenie]
synonym: "up regulation of bilirubin uridine diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of ciramadol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of estriol UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of estrone UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of glucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of GT activity" EXACT [GOC:TermGenie]
synonym: "up regulation of morphine glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of p-hydroxybiphenyl UDP glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of p-nitrophenol UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of p-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of p-nitrophenylglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of p-phenylphenol glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of phenyl-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of PNP-UDPGT" RELATED [GOC:TermGenie]
synonym: "up regulation of pnp-UDPGT activity" NARROW [GOC:TermGenie]
synonym: "up regulation of UDP glucuronate-estradiol-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of UDP glucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of UDP glucuronic acid transferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of UDP glucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of UDP glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)" EXACT [GOC:TermGenie]
synonym: "up regulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of UDP-glucuronate-bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of UDP-glucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of UDP-glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of UDPGA transferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of UDPGA-glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity" NARROW [GOC:TermGenie]
synonym: "up regulation of UDPGT activity" EXACT [GOC:TermGenie]
synonym: "up regulation of uridine 5'-diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of uridine diphosphate glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of uridine diphosphoglucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of uridine diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of 1-naphthol glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of 1-naphthol-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of 17-OH steroid UDPGT activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of 3-OH androgenic UDPGT activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of 4-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of 4-nitrophenol UDPGT activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of bilirubin monoglucuronide glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of bilirubin UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of bilirubin UDPGT activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of bilirubin uridine diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of ciramadol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of estriol UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of estrone UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of glucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of GT activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of morphine glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of p-hydroxybiphenyl UDP glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of p-nitrophenol UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of p-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of p-nitrophenylglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of p-phenylphenol glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of phenyl-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of PNP-UDPGT" RELATED [GOC:TermGenie]
synonym: "up-regulation of pnp-UDPGT activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of UDP glucuronate-estradiol-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of UDP glucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of UDP glucuronic acid transferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of UDP glucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of UDP glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)" EXACT [GOC:TermGenie]
synonym: "up-regulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of UDP-glucuronate-bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of UDP-glucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of UDP-glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of UDPGA transferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of UDPGA-glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of UDPGT activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of uridine 5'-diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of uridine diphosphate glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of uridine diphosphoglucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of uridine diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of 1-naphthol glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of 1-naphthol-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of 17-OH steroid UDPGT activity" NARROW [GOC:TermGenie]
synonym: "upregulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of 3-OH androgenic UDPGT activity" NARROW [GOC:TermGenie]
synonym: "upregulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of 4-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of 4-nitrophenol UDPGT activity" NARROW [GOC:TermGenie]
synonym: "upregulation of bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of bilirubin monoglucuronide glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of bilirubin UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of bilirubin UDPGT activity" NARROW [GOC:TermGenie]
synonym: "upregulation of bilirubin uridine diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of ciramadol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of estriol UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of estrone UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of glucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of GT activity" EXACT [GOC:TermGenie]
synonym: "upregulation of morphine glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of p-hydroxybiphenyl UDP glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of p-nitrophenol UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of p-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of p-nitrophenylglucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of p-phenylphenol glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of phenyl-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of PNP-UDPGT" RELATED [GOC:TermGenie]
synonym: "upregulation of pnp-UDPGT activity" NARROW [GOC:TermGenie]
synonym: "upregulation of UDP glucuronate-estradiol-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of UDP glucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of UDP glucuronic acid transferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of UDP glucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of UDP glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)" EXACT [GOC:TermGenie]
synonym: "upregulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of UDP-glucuronate-bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of UDP-glucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of UDP-glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of UDPGA transferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of UDPGA-glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity" NARROW [GOC:TermGenie]
synonym: "upregulation of UDPGT activity" EXACT [GOC:TermGenie]
synonym: "upregulation of uridine 5'-diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of uridine diphosphate glucuronyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of uridine diphosphoglucuronosyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of uridine diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie]
is_a: GO:0051347 ! positive regulation of transferase activity
is_a: GO:1904223 ! regulation of glucuronosyltransferase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0015020 ! glucuronosyltransferase activity
relationship: positively_regulates GO:0015020 ! glucuronosyltransferase activity
created_by: rl
creation_date: 2015-05-15T08:44:32Z

[Term]
id: GO:1904226
name: regulation of glycogen synthase activity, transferring glucose-1-phosphate
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glycogen synthase activity, transferring glucose-1-phosphate." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17569761]
is_a: GO:0051338 ! regulation of transferase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061547 ! glycogen synthase activity, transferring glucose-1-phosphate
relationship: regulates GO:0061547 ! glycogen synthase activity, transferring glucose-1-phosphate
created_by: rl
creation_date: 2015-05-15T09:23:08Z

[Term]
id: GO:1904227
name: negative regulation of glycogen synthase activity, transferring glucose-1-phosphate
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glycogen synthase activity, transferring glucose-1-phosphate." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17569761]
synonym: "down regulation of glycogen synthase activity, transferring glucose-1-phosphate" EXACT [GOC:TermGenie]
synonym: "down-regulation of glycogen synthase activity, transferring glucose-1-phosphate" EXACT [GOC:TermGenie]
synonym: "downregulation of glycogen synthase activity, transferring glucose-1-phosphate" EXACT [GOC:TermGenie]
synonym: "inhibition of glycogen synthase activity, transferring glucose-1-phosphate" NARROW [GOC:TermGenie]
is_a: GO:0051348 ! negative regulation of transferase activity
is_a: GO:1904226 ! regulation of glycogen synthase activity, transferring glucose-1-phosphate
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061547 ! glycogen synthase activity, transferring glucose-1-phosphate
relationship: negatively_regulates GO:0061547 ! glycogen synthase activity, transferring glucose-1-phosphate
created_by: rl
creation_date: 2015-05-15T09:23:14Z

[Term]
id: GO:1904228
name: positive regulation of glycogen synthase activity, transferring glucose-1-phosphate
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glycogen synthase activity, transferring glucose-1-phosphate." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17569761]
synonym: "activation of glycogen synthase activity, transferring glucose-1-phosphate" NARROW [GOC:TermGenie]
synonym: "up regulation of glycogen synthase activity, transferring glucose-1-phosphate" EXACT [GOC:TermGenie]
synonym: "up-regulation of glycogen synthase activity, transferring glucose-1-phosphate" EXACT [GOC:TermGenie]
synonym: "upregulation of glycogen synthase activity, transferring glucose-1-phosphate" EXACT [GOC:TermGenie]
is_a: GO:0051347 ! positive regulation of transferase activity
is_a: GO:1904226 ! regulation of glycogen synthase activity, transferring glucose-1-phosphate
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061547 ! glycogen synthase activity, transferring glucose-1-phosphate
relationship: positively_regulates GO:0061547 ! glycogen synthase activity, transferring glucose-1-phosphate
created_by: rl
creation_date: 2015-05-15T09:23:20Z

[Term]
id: GO:1904229
name: regulation of succinate dehydrogenase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of succinate dehydrogenase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18160053]
synonym: "regulation of fumarate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "regulation of fumarate reductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of fumaric hydrogenase activity" EXACT [GOC:TermGenie]
synonym: "regulation of succinate oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of succinate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of succinate:acceptor oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of succinic acid dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "regulation of succinic dehydrogenase activity" BROAD [GOC:TermGenie]
synonym: "regulation of succinodehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "regulation of succinyl dehydrogenase activity" EXACT [GOC:TermGenie]
is_a: GO:0051341 ! regulation of oxidoreductase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000104 ! succinate dehydrogenase activity
relationship: regulates GO:0000104 ! succinate dehydrogenase activity
created_by: rl
creation_date: 2015-05-15T09:51:08Z

[Term]
id: GO:1904230
name: negative regulation of succinate dehydrogenase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of succinate dehydrogenase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18160053]
synonym: "down regulation of fumarate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of fumarate reductase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of fumaric hydrogenase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of succinate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of succinate oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of succinate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of succinate:acceptor oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of succinic acid dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of succinodehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of succinyl dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of fumarate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of fumarate reductase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of fumaric hydrogenase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of succinate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of succinate oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of succinate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of succinate:acceptor oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of succinic acid dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of succinodehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of succinyl dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of fumarate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of fumarate reductase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of fumaric hydrogenase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of succinate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of succinate oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of succinate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of succinate:acceptor oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of succinic acid dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of succinodehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of succinyl dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of fumarate dehydrogenase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of fumarate reductase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of fumaric hydrogenase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of succinate dehydrogenase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of succinate oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of succinate:(acceptor) oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of succinate:acceptor oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of succinic acid dehydrogenase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of succinodehydrogenase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of succinyl dehydrogenase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of fumarate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of fumarate reductase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of fumaric hydrogenase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of succinate oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of succinate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of succinate:acceptor oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of succinic acid dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of succinodehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of succinyl dehydrogenase activity" EXACT [GOC:TermGenie]
is_a: GO:0051354 ! negative regulation of oxidoreductase activity
is_a: GO:1904229 ! regulation of succinate dehydrogenase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000104 ! succinate dehydrogenase activity
relationship: negatively_regulates GO:0000104 ! succinate dehydrogenase activity
created_by: rl
creation_date: 2015-05-15T09:51:14Z

[Term]
id: GO:1904231
name: positive regulation of succinate dehydrogenase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of succinate dehydrogenase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18160053]
synonym: "activation of fumarate dehydrogenase activity" NARROW [GOC:TermGenie]
synonym: "activation of fumarate reductase activity" NARROW [GOC:TermGenie]
synonym: "activation of fumaric hydrogenase activity" NARROW [GOC:TermGenie]
synonym: "activation of succinate dehydrogenase activity" NARROW [GOC:TermGenie]
synonym: "activation of succinate oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "activation of succinate:(acceptor) oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "activation of succinate:acceptor oxidoreductase activity" NARROW [GOC:TermGenie]
synonym: "activation of succinic acid dehydrogenase activity" NARROW [GOC:TermGenie]
synonym: "activation of succinodehydrogenase activity" NARROW [GOC:TermGenie]
synonym: "activation of succinyl dehydrogenase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of fumarate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of fumarate reductase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of fumaric hydrogenase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of succinate oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of succinate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of succinate:acceptor oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of succinic acid dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of succinodehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of succinyl dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of fumarate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of fumarate reductase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of fumaric hydrogenase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of succinate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of succinate oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of succinate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of succinate:acceptor oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of succinic acid dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of succinodehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of succinyl dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of fumarate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of fumarate reductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of fumaric hydrogenase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of succinate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of succinate oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of succinate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of succinate:acceptor oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of succinic acid dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of succinodehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of succinyl dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of fumarate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of fumarate reductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of fumaric hydrogenase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of succinate dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of succinate oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of succinate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of succinate:acceptor oxidoreductase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of succinic acid dehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of succinodehydrogenase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of succinyl dehydrogenase activity" EXACT [GOC:TermGenie]
is_a: GO:0051353 ! positive regulation of oxidoreductase activity
is_a: GO:1904229 ! regulation of succinate dehydrogenase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000104 ! succinate dehydrogenase activity
relationship: positively_regulates GO:0000104 ! succinate dehydrogenase activity
created_by: rl
creation_date: 2015-05-15T09:51:20Z

[Term]
id: GO:1904232
name: regulation of aconitate hydratase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of aconitate hydratase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18160053]
synonym: "regulation of aconitase activity" EXACT [GOC:TermGenie]
synonym: "regulation of cis-aconitase activity" EXACT [GOC:TermGenie]
synonym: "regulation of citrate hydro-lyase activity" BROAD [GOC:TermGenie]
synonym: "regulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" EXACT [GOC:TermGenie]
synonym: "regulation of citrate(isocitrate) hydro-lyase activity" EXACT [GOC:TermGenie]
is_a: GO:0051339 ! regulation of lyase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003994 ! aconitate hydratase activity
relationship: regulates GO:0003994 ! aconitate hydratase activity
created_by: rl
creation_date: 2015-05-15T09:55:17Z

[Term]
id: GO:1904233
name: negative regulation of aconitate hydratase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of aconitate hydratase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18160053]
synonym: "down regulation of aconitase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of aconitate hydratase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of cis-aconitase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" EXACT [GOC:TermGenie]
synonym: "down regulation of citrate(isocitrate) hydro-lyase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of aconitase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of aconitate hydratase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of cis-aconitase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" EXACT [GOC:TermGenie]
synonym: "down-regulation of citrate(isocitrate) hydro-lyase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of aconitase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of aconitate hydratase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of cis-aconitase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" EXACT [GOC:TermGenie]
synonym: "downregulation of citrate(isocitrate) hydro-lyase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of aconitase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of aconitate hydratase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of cis-aconitase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" NARROW [GOC:TermGenie]
synonym: "inhibition of citrate(isocitrate) hydro-lyase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of aconitase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of cis-aconitase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" EXACT [GOC:TermGenie]
synonym: "negative regulation of citrate(isocitrate) hydro-lyase activity" EXACT [GOC:TermGenie]
is_a: GO:0051350 ! negative regulation of lyase activity
is_a: GO:1904232 ! regulation of aconitate hydratase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003994 ! aconitate hydratase activity
relationship: negatively_regulates GO:0003994 ! aconitate hydratase activity
created_by: rl
creation_date: 2015-05-15T09:55:23Z

[Term]
id: GO:1904234
name: positive regulation of aconitate hydratase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of aconitate hydratase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18160053]
synonym: "activation of aconitase activity" NARROW [GOC:TermGenie]
synonym: "activation of aconitate hydratase activity" NARROW [GOC:TermGenie]
synonym: "activation of cis-aconitase activity" NARROW [GOC:TermGenie]
synonym: "activation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" NARROW [GOC:TermGenie]
synonym: "activation of citrate(isocitrate) hydro-lyase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of aconitase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of cis-aconitase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" EXACT [GOC:TermGenie]
synonym: "positive regulation of citrate(isocitrate) hydro-lyase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of aconitase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of aconitate hydratase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of cis-aconitase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" EXACT [GOC:TermGenie]
synonym: "up regulation of citrate(isocitrate) hydro-lyase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of aconitase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of aconitate hydratase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of cis-aconitase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" EXACT [GOC:TermGenie]
synonym: "up-regulation of citrate(isocitrate) hydro-lyase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of aconitase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of aconitate hydratase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of cis-aconitase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" EXACT [GOC:TermGenie]
synonym: "upregulation of citrate(isocitrate) hydro-lyase activity" EXACT [GOC:TermGenie]
is_a: GO:0051349 ! positive regulation of lyase activity
is_a: GO:1904232 ! regulation of aconitate hydratase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003994 ! aconitate hydratase activity
relationship: positively_regulates GO:0003994 ! aconitate hydratase activity
created_by: rl
creation_date: 2015-05-15T09:55:29Z

[Term]
id: GO:1904235
name: regulation of substrate-dependent cell migration, cell attachment to substrate
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of substrate-dependent cell migration, cell attachment to substrate." [GO_REF:0000058, GOC:TermGenie, PMID:25834989]
synonym: "regulation of substrate-bound cell migration, cell attachment to substrate" EXACT [GOC:TermGenie]
is_a: GO:0010810 ! regulation of cell-substrate adhesion
is_a: GO:0030334 ! regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006931 ! substrate-dependent cell migration, cell attachment to substrate
relationship: regulates GO:0006931 ! substrate-dependent cell migration, cell attachment to substrate
created_by: pga
creation_date: 2015-05-15T13:29:59Z

[Term]
id: GO:1904236
name: negative regulation of substrate-dependent cell migration, cell attachment to substrate
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of substrate-dependent cell migration, cell attachment to substrate." [GO_REF:0000058, GOC:TermGenie, PMID:25834989]
synonym: "down regulation of substrate-bound cell migration, cell attachment to substrate" EXACT [GOC:TermGenie]
synonym: "down regulation of substrate-dependent cell migration, cell attachment to substrate" EXACT [GOC:TermGenie]
synonym: "down-regulation of substrate-bound cell migration, cell attachment to substrate" EXACT [GOC:TermGenie]
synonym: "down-regulation of substrate-dependent cell migration, cell attachment to substrate" EXACT [GOC:TermGenie]
synonym: "downregulation of substrate-bound cell migration, cell attachment to substrate" EXACT [GOC:TermGenie]
synonym: "downregulation of substrate-dependent cell migration, cell attachment to substrate" EXACT [GOC:TermGenie]
synonym: "inhibition of substrate-bound cell migration, cell attachment to substrate" NARROW [GOC:TermGenie]
synonym: "inhibition of substrate-dependent cell migration, cell attachment to substrate" NARROW [GOC:TermGenie]
synonym: "negative regulation of substrate-bound cell migration, cell attachment to substrate" EXACT [GOC:TermGenie]
is_a: GO:0010812 ! negative regulation of cell-substrate adhesion
is_a: GO:0030336 ! negative regulation of cell migration
is_a: GO:1904235 ! regulation of substrate-dependent cell migration, cell attachment to substrate
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006931 ! substrate-dependent cell migration, cell attachment to substrate
relationship: negatively_regulates GO:0006931 ! substrate-dependent cell migration, cell attachment to substrate
created_by: pga
creation_date: 2015-05-15T13:30:05Z

[Term]
id: GO:1904237
name: positive regulation of substrate-dependent cell migration, cell attachment to substrate
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of substrate-dependent cell migration, cell attachment to substrate." [GO_REF:0000058, GOC:TermGenie, PMID:25834989]
synonym: "activation of substrate-bound cell migration, cell attachment to substrate" NARROW [GOC:TermGenie]
synonym: "activation of substrate-dependent cell migration, cell attachment to substrate" NARROW [GOC:TermGenie]
synonym: "positive regulation of substrate-bound cell migration, cell attachment to substrate" EXACT [GOC:TermGenie]
synonym: "up regulation of substrate-bound cell migration, cell attachment to substrate" EXACT [GOC:TermGenie]
synonym: "up regulation of substrate-dependent cell migration, cell attachment to substrate" EXACT [GOC:TermGenie]
synonym: "up-regulation of substrate-bound cell migration, cell attachment to substrate" EXACT [GOC:TermGenie]
synonym: "up-regulation of substrate-dependent cell migration, cell attachment to substrate" EXACT [GOC:TermGenie]
synonym: "upregulation of substrate-bound cell migration, cell attachment to substrate" EXACT [GOC:TermGenie]
synonym: "upregulation of substrate-dependent cell migration, cell attachment to substrate" EXACT [GOC:TermGenie]
is_a: GO:0010811 ! positive regulation of cell-substrate adhesion
is_a: GO:0030335 ! positive regulation of cell migration
is_a: GO:1904235 ! regulation of substrate-dependent cell migration, cell attachment to substrate
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006931 ! substrate-dependent cell migration, cell attachment to substrate
relationship: positively_regulates GO:0006931 ! substrate-dependent cell migration, cell attachment to substrate
created_by: pga
creation_date: 2015-05-15T13:30:11Z

[Term]
id: GO:1904238
name: pericyte cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a pericyte cell." [GO_REF:0000086, GOC:dph, GOC:TermGenie, PMID:23868830]
is_a: GO:0030154 ! cell differentiation
created_by: dph
creation_date: 2015-05-15T14:50:13Z

[Term]
id: GO:1904239
name: regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of VCP-NPL4-UFD1 AAA ATPase complex assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly" NARROW [GOC:TermGenie]
synonym: "regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation" NARROW [GOC:TermGenie]
synonym: "regulation of p97-Ufd1-Npl4 complex assembly" EXACT [GOC:TermGenie]
synonym: "regulation of p97-Ufd1-Npl4 complex formation" EXACT [GOC:TermGenie]
synonym: "regulation of VCP-NPL4-UFD1 AAA ATPase complex formation" EXACT [GOC:TermGenie]
is_a: GO:0043254 ! regulation of protein complex assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1904210 ! VCP-NPL4-UFD1 AAA ATPase complex assembly
relationship: regulates GO:1904210 ! VCP-NPL4-UFD1 AAA ATPase complex assembly
created_by: bf
creation_date: 2015-05-18T09:50:21Z

[Term]
id: GO:1904240
name: negative regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of VCP-NPL4-UFD1 AAA ATPase complex assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:17000876]
synonym: "down regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly" NARROW [GOC:TermGenie]
synonym: "down regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation" NARROW [GOC:TermGenie]
synonym: "down regulation of p97-Ufd1-Npl4 complex assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of p97-Ufd1-Npl4 complex formation" EXACT [GOC:TermGenie]
synonym: "down regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of VCP-NPL4-UFD1 AAA ATPase complex formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly" NARROW [GOC:TermGenie]
synonym: "down-regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation" NARROW [GOC:TermGenie]
synonym: "down-regulation of p97-Ufd1-Npl4 complex assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of p97-Ufd1-Npl4 complex formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of VCP-NPL4-UFD1 AAA ATPase complex formation" EXACT [GOC:TermGenie]
synonym: "downregulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly" NARROW [GOC:TermGenie]
synonym: "downregulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation" NARROW [GOC:TermGenie]
synonym: "downregulation of p97-Ufd1-Npl4 complex assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of p97-Ufd1-Npl4 complex formation" EXACT [GOC:TermGenie]
synonym: "downregulation of VCP-NPL4-UFD1 AAA ATPase complex assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of VCP-NPL4-UFD1 AAA ATPase complex formation" EXACT [GOC:TermGenie]
synonym: "inhibition of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation" NARROW [GOC:TermGenie]
synonym: "inhibition of p97-Ufd1-Npl4 complex assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of p97-Ufd1-Npl4 complex formation" NARROW [GOC:TermGenie]
synonym: "inhibition of VCP-NPL4-UFD1 AAA ATPase complex assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of VCP-NPL4-UFD1 AAA ATPase complex formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly" NARROW [GOC:TermGenie]
synonym: "negative regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of p97-Ufd1-Npl4 complex assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of p97-Ufd1-Npl4 complex formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of VCP-NPL4-UFD1 AAA ATPase complex formation" EXACT [GOC:TermGenie]
is_a: GO:0031333 ! negative regulation of protein complex assembly
is_a: GO:1904239 ! regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1904210 ! VCP-NPL4-UFD1 AAA ATPase complex assembly
relationship: negatively_regulates GO:1904210 ! VCP-NPL4-UFD1 AAA ATPase complex assembly
created_by: bf
creation_date: 2015-05-18T09:50:27Z

[Term]
id: GO:1904241
name: positive regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of VCP-NPL4-UFD1 AAA ATPase complex assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "activation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly" NARROW [GOC:TermGenie]
synonym: "activation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation" NARROW [GOC:TermGenie]
synonym: "activation of p97-Ufd1-Npl4 complex assembly" NARROW [GOC:TermGenie]
synonym: "activation of p97-Ufd1-Npl4 complex formation" NARROW [GOC:TermGenie]
synonym: "activation of VCP-NPL4-UFD1 AAA ATPase complex assembly" NARROW [GOC:TermGenie]
synonym: "activation of VCP-NPL4-UFD1 AAA ATPase complex formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly" NARROW [GOC:TermGenie]
synonym: "positive regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of p97-Ufd1-Npl4 complex assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of p97-Ufd1-Npl4 complex formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of VCP-NPL4-UFD1 AAA ATPase complex formation" EXACT [GOC:TermGenie]
synonym: "up regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly" NARROW [GOC:TermGenie]
synonym: "up regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation" NARROW [GOC:TermGenie]
synonym: "up regulation of p97-Ufd1-Npl4 complex assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of p97-Ufd1-Npl4 complex formation" EXACT [GOC:TermGenie]
synonym: "up regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of VCP-NPL4-UFD1 AAA ATPase complex formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly" NARROW [GOC:TermGenie]
synonym: "up-regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation" NARROW [GOC:TermGenie]
synonym: "up-regulation of p97-Ufd1-Npl4 complex assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of p97-Ufd1-Npl4 complex formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of VCP-NPL4-UFD1 AAA ATPase complex formation" EXACT [GOC:TermGenie]
synonym: "upregulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly" NARROW [GOC:TermGenie]
synonym: "upregulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation" NARROW [GOC:TermGenie]
synonym: "upregulation of p97-Ufd1-Npl4 complex assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of p97-Ufd1-Npl4 complex formation" EXACT [GOC:TermGenie]
synonym: "upregulation of VCP-NPL4-UFD1 AAA ATPase complex assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of VCP-NPL4-UFD1 AAA ATPase complex formation" EXACT [GOC:TermGenie]
is_a: GO:0031334 ! positive regulation of protein complex assembly
is_a: GO:1904239 ! regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1904210 ! VCP-NPL4-UFD1 AAA ATPase complex assembly
relationship: positively_regulates GO:1904210 ! VCP-NPL4-UFD1 AAA ATPase complex assembly
created_by: bf
creation_date: 2015-05-18T09:50:34Z

[Term]
id: GO:1904242
name: regulation of pancreatic trypsinogen secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pancreatic trypsinogen secretion." [GO_REF:0000058, GOC:TermGenie, PMID:12771515]
synonym: "regulation of pancreatic trypsinogen release" EXACT [GOC:TermGenie]
is_a: GO:0050708 ! regulation of protein secretion
is_a: GO:0090186 ! regulation of pancreatic juice secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990747 ! pancreatic trypsinogen secretion
relationship: regulates GO:1990747 ! pancreatic trypsinogen secretion
created_by: sl
creation_date: 2015-05-18T19:49:20Z

[Term]
id: GO:1904243
name: negative regulation of pancreatic trypsinogen secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of pancreatic trypsinogen secretion." [GO_REF:0000058, GOC:TermGenie, PMID:12771515]
synonym: "down regulation of pancreatic trypsinogen release" EXACT [GOC:TermGenie]
synonym: "down regulation of pancreatic trypsinogen secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of pancreatic trypsinogen release" EXACT [GOC:TermGenie]
synonym: "down-regulation of pancreatic trypsinogen secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of pancreatic trypsinogen release" EXACT [GOC:TermGenie]
synonym: "downregulation of pancreatic trypsinogen secretion" EXACT [GOC:TermGenie]
synonym: "inhibition of pancreatic trypsinogen release" NARROW [GOC:TermGenie]
synonym: "inhibition of pancreatic trypsinogen secretion" NARROW [GOC:TermGenie]
synonym: "negative regulation of pancreatic trypsinogen release" EXACT [GOC:TermGenie]
is_a: GO:0050709 ! negative regulation of protein secretion
is_a: GO:0090188 ! negative regulation of pancreatic juice secretion
is_a: GO:1904242 ! regulation of pancreatic trypsinogen secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990747 ! pancreatic trypsinogen secretion
relationship: negatively_regulates GO:1990747 ! pancreatic trypsinogen secretion
created_by: sl
creation_date: 2015-05-18T19:49:27Z

[Term]
id: GO:1904244
name: positive regulation of pancreatic trypsinogen secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pancreatic trypsinogen secretion." [GO_REF:0000058, GOC:TermGenie, PMID:12771515]
synonym: "activation of pancreatic trypsinogen release" NARROW [GOC:TermGenie]
synonym: "activation of pancreatic trypsinogen secretion" NARROW [GOC:TermGenie]
synonym: "positive regulation of pancreatic trypsinogen release" EXACT [GOC:TermGenie]
synonym: "up regulation of pancreatic trypsinogen release" EXACT [GOC:TermGenie]
synonym: "up regulation of pancreatic trypsinogen secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of pancreatic trypsinogen release" EXACT [GOC:TermGenie]
synonym: "up-regulation of pancreatic trypsinogen secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of pancreatic trypsinogen release" EXACT [GOC:TermGenie]
synonym: "upregulation of pancreatic trypsinogen secretion" EXACT [GOC:TermGenie]
is_a: GO:0050714 ! positive regulation of protein secretion
is_a: GO:0090187 ! positive regulation of pancreatic juice secretion
is_a: GO:1904242 ! regulation of pancreatic trypsinogen secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990747 ! pancreatic trypsinogen secretion
relationship: positively_regulates GO:1990747 ! pancreatic trypsinogen secretion
created_by: sl
creation_date: 2015-05-18T19:49:32Z

[Term]
id: GO:1904245
name: regulation of polynucleotide adenylyltransferase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of polynucleotide adenylyltransferase activity." [GO_REF:0000059, GOC:kmv, GOC:TermGenie, PMID:19460348]
synonym: "regulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of AMP polynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of ATP-polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of ATP:polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of ATP:polynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of NTP polymerase activity" EXACT [GOC:TermGenie]
synonym: "regulation of poly(A) hydrolase activity" EXACT [GOC:TermGenie]
synonym: "regulation of poly(A) polymerase activity" EXACT [GOC:TermGenie]
synonym: "regulation of poly(A) synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of poly-A polymerase activity" EXACT [GOC:TermGenie]
synonym: "regulation of polyadenylate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of polyadenylate polymerase activity" EXACT [GOC:TermGenie]
synonym: "regulation of polyadenylate synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of polyadenylic acid polymerase activity" EXACT [GOC:TermGenie]
synonym: "regulation of polyadenylic polymerase activity" EXACT [GOC:TermGenie]
synonym: "regulation of RNA adenylating enzyme activity" EXACT [GOC:TermGenie]
synonym: "regulation of RNA formation factors, PF1" RELATED [GOC:TermGenie]
synonym: "regulation of terminal riboadenylate transferase activity" EXACT [GOC:TermGenie]
is_a: GO:0051338 ! regulation of transferase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004652 ! polynucleotide adenylyltransferase activity
relationship: regulates GO:0004652 ! polynucleotide adenylyltransferase activity
created_by: kmv
creation_date: 2015-05-19T14:47:20Z

[Term]
id: GO:1904246
name: negative regulation of polynucleotide adenylyltransferase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of polynucleotide adenylyltransferase activity." [GO_REF:0000059, GOC:kmv, GOC:TermGenie, PMID:19460348]
synonym: "down regulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of AMP polynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of ATP-polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of ATP:polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of ATP:polynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of NTP polymerase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of poly(A) hydrolase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of poly(A) polymerase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of poly(A) synthetase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of poly-A polymerase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of polyadenylate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of polyadenylate polymerase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of polyadenylate synthetase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of polyadenylic acid polymerase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of polyadenylic polymerase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of RNA adenylating enzyme activity" EXACT [GOC:TermGenie]
synonym: "down regulation of RNA formation factors, PF1" RELATED [GOC:TermGenie]
synonym: "down regulation of terminal riboadenylate transferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of AMP polynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of ATP-polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of ATP:polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of ATP:polynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of NTP polymerase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of poly(A) hydrolase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of poly(A) polymerase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of poly(A) synthetase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of poly-A polymerase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of polyadenylate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of polyadenylate polymerase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of polyadenylate synthetase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of polyadenylic acid polymerase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of polyadenylic polymerase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA adenylating enzyme activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA formation factors, PF1" RELATED [GOC:TermGenie]
synonym: "down-regulation of terminal riboadenylate transferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of AMP polynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of ATP-polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of ATP:polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of ATP:polynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of NTP polymerase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of poly(A) hydrolase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of poly(A) polymerase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of poly(A) synthetase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of poly-A polymerase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of polyadenylate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of polyadenylate polymerase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of polyadenylate synthetase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of polyadenylic acid polymerase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of polyadenylic polymerase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA adenylating enzyme activity" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA formation factors, PF1" RELATED [GOC:TermGenie]
synonym: "downregulation of terminal riboadenylate transferase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of adenosine triphosphate:ribonucleic acid adenylyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of AMP polynucleotidylexotransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of ATP-polynucleotide adenylyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of ATP:polynucleotide adenylyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of ATP:polynucleotidylexotransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of NTP polymerase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of poly(A) hydrolase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of poly(A) polymerase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of poly(A) synthetase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of poly-A polymerase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of polyadenylate nucleotidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of polyadenylate polymerase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of polyadenylate synthetase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of polyadenylic acid polymerase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of polyadenylic polymerase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of polynucleotide adenylyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of RNA adenylating enzyme activity" NARROW [GOC:TermGenie]
synonym: "inhibition of RNA formation factors, PF1" RELATED [GOC:TermGenie]
synonym: "inhibition of terminal riboadenylate transferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of AMP polynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of ATP-polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of ATP:polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of ATP:polynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of NTP polymerase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of poly(A) hydrolase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of poly(A) polymerase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of poly(A) synthetase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of poly-A polymerase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of polyadenylate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of polyadenylate polymerase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of polyadenylate synthetase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of polyadenylic acid polymerase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of polyadenylic polymerase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of RNA adenylating enzyme activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of RNA formation factors, PF1" RELATED [GOC:TermGenie]
synonym: "negative regulation of terminal riboadenylate transferase activity" EXACT [GOC:TermGenie]
is_a: GO:0051348 ! negative regulation of transferase activity
is_a: GO:1904245 ! regulation of polynucleotide adenylyltransferase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004652 ! polynucleotide adenylyltransferase activity
relationship: negatively_regulates GO:0004652 ! polynucleotide adenylyltransferase activity
created_by: kmv
creation_date: 2015-05-19T14:47:26Z

[Term]
id: GO:1904247
name: positive regulation of polynucleotide adenylyltransferase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of polynucleotide adenylyltransferase activity." [GO_REF:0000059, GOC:kmv, GOC:TermGenie, PMID:19460348]
synonym: "activation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of AMP polynucleotidylexotransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of ATP-polynucleotide adenylyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of ATP:polynucleotide adenylyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of ATP:polynucleotidylexotransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of NTP polymerase activity" NARROW [GOC:TermGenie]
synonym: "activation of poly(A) hydrolase activity" NARROW [GOC:TermGenie]
synonym: "activation of poly(A) polymerase activity" NARROW [GOC:TermGenie]
synonym: "activation of poly(A) synthetase activity" NARROW [GOC:TermGenie]
synonym: "activation of poly-A polymerase activity" NARROW [GOC:TermGenie]
synonym: "activation of polyadenylate nucleotidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of polyadenylate polymerase activity" NARROW [GOC:TermGenie]
synonym: "activation of polyadenylate synthetase activity" NARROW [GOC:TermGenie]
synonym: "activation of polyadenylic acid polymerase activity" NARROW [GOC:TermGenie]
synonym: "activation of polyadenylic polymerase activity" NARROW [GOC:TermGenie]
synonym: "activation of polynucleotide adenylyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of RNA adenylating enzyme activity" NARROW [GOC:TermGenie]
synonym: "activation of RNA formation factors, PF1" RELATED [GOC:TermGenie]
synonym: "activation of terminal riboadenylate transferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of AMP polynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of ATP-polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of ATP:polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of ATP:polynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of NTP polymerase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of poly(A) hydrolase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of poly(A) polymerase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of poly(A) synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of poly-A polymerase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of polyadenylate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of polyadenylate polymerase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of polyadenylate synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of polyadenylic acid polymerase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of polyadenylic polymerase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of RNA adenylating enzyme activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of RNA formation factors, PF1" RELATED [GOC:TermGenie]
synonym: "positive regulation of terminal riboadenylate transferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of AMP polynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of ATP-polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of ATP:polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of ATP:polynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of NTP polymerase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of poly(A) hydrolase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of poly(A) polymerase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of poly(A) synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of poly-A polymerase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of polyadenylate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of polyadenylate polymerase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of polyadenylate synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of polyadenylic acid polymerase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of polyadenylic polymerase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of RNA adenylating enzyme activity" EXACT [GOC:TermGenie]
synonym: "up regulation of RNA formation factors, PF1" RELATED [GOC:TermGenie]
synonym: "up regulation of terminal riboadenylate transferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of AMP polynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of ATP-polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of ATP:polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of ATP:polynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of NTP polymerase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of poly(A) hydrolase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of poly(A) polymerase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of poly(A) synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of poly-A polymerase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of polyadenylate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of polyadenylate polymerase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of polyadenylate synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of polyadenylic acid polymerase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of polyadenylic polymerase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNA adenylating enzyme activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNA formation factors, PF1" RELATED [GOC:TermGenie]
synonym: "up-regulation of terminal riboadenylate transferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of AMP polynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of ATP-polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of ATP:polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of ATP:polynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of NTP polymerase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of poly(A) hydrolase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of poly(A) polymerase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of poly(A) synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of poly-A polymerase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of polyadenylate nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of polyadenylate polymerase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of polyadenylate synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of polyadenylic acid polymerase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of polyadenylic polymerase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA adenylating enzyme activity" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA formation factors, PF1" RELATED [GOC:TermGenie]
synonym: "upregulation of terminal riboadenylate transferase activity" EXACT [GOC:TermGenie]
is_a: GO:0051347 ! positive regulation of transferase activity
is_a: GO:1904245 ! regulation of polynucleotide adenylyltransferase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004652 ! polynucleotide adenylyltransferase activity
relationship: positively_regulates GO:0004652 ! polynucleotide adenylyltransferase activity
created_by: kmv
creation_date: 2015-05-19T14:47:32Z

[Term]
id: GO:1904248
name: regulation of age-related resistance
namespace: biological_process
def: "Any process that modulates the extent of age-related resistance." [GO_REF:0000058, GOC:TermGenie, PMID:19694953]
synonym: "regulation of adult seedling resistance" NARROW [GOC:TermGenie]
synonym: "regulation of ARR" EXACT [GOC:TermGenie]
synonym: "regulation of developmental resistance" BROAD [GOC:TermGenie]
synonym: "regulation of flowering-induced resistance" NARROW [GOC:TermGenie]
synonym: "regulation of mature seedling resistance" NARROW [GOC:TermGenie]
synonym: "regulation of ontogenic resistance" BROAD [GOC:TermGenie]
synonym: "regulation of senescence-induced resistance" NARROW [GOC:TermGenie]
is_a: GO:0045088 ! regulation of innate immune response
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0090644 ! age-related resistance
relationship: regulates GO:0090644 ! age-related resistance
created_by: tb
creation_date: 2015-05-19T20:19:58Z

[Term]
id: GO:1904249
name: negative regulation of age-related resistance
namespace: biological_process
def: "Any process that stops, prevents or reduces the extent of age-related resistance." [GO_REF:0000058, GOC:TermGenie, PMID:19694953]
synonym: "down regulation of adult seedling resistance" NARROW [GOC:TermGenie]
synonym: "down regulation of age-related resistance" EXACT [GOC:TermGenie]
synonym: "down regulation of ARR" EXACT [GOC:TermGenie]
synonym: "down regulation of flowering-induced resistance" NARROW [GOC:TermGenie]
synonym: "down regulation of mature seedling resistance" NARROW [GOC:TermGenie]
synonym: "down regulation of senescence-induced resistance" NARROW [GOC:TermGenie]
synonym: "down-regulation of adult seedling resistance" NARROW [GOC:TermGenie]
synonym: "down-regulation of age-related resistance" EXACT [GOC:TermGenie]
synonym: "down-regulation of ARR" EXACT [GOC:TermGenie]
synonym: "down-regulation of flowering-induced resistance" NARROW [GOC:TermGenie]
synonym: "down-regulation of mature seedling resistance" NARROW [GOC:TermGenie]
synonym: "down-regulation of senescence-induced resistance" NARROW [GOC:TermGenie]
synonym: "downregulation of adult seedling resistance" NARROW [GOC:TermGenie]
synonym: "downregulation of age-related resistance" EXACT [GOC:TermGenie]
synonym: "downregulation of ARR" EXACT [GOC:TermGenie]
synonym: "downregulation of flowering-induced resistance" NARROW [GOC:TermGenie]
synonym: "downregulation of mature seedling resistance" NARROW [GOC:TermGenie]
synonym: "downregulation of senescence-induced resistance" NARROW [GOC:TermGenie]
synonym: "inhibition of adult seedling resistance" NARROW [GOC:TermGenie]
synonym: "inhibition of age-related resistance" NARROW [GOC:TermGenie]
synonym: "inhibition of ARR" NARROW [GOC:TermGenie]
synonym: "inhibition of flowering-induced resistance" NARROW [GOC:TermGenie]
synonym: "inhibition of mature seedling resistance" NARROW [GOC:TermGenie]
synonym: "inhibition of senescence-induced resistance" NARROW [GOC:TermGenie]
synonym: "negative regulation of adult seedling resistance" NARROW [GOC:TermGenie]
synonym: "negative regulation of ARR" EXACT [GOC:TermGenie]
synonym: "negative regulation of flowering-induced resistance" NARROW [GOC:TermGenie]
synonym: "negative regulation of mature seedling resistance" NARROW [GOC:TermGenie]
synonym: "negative regulation of senescence-induced resistance" NARROW [GOC:TermGenie]
is_a: GO:0045824 ! negative regulation of innate immune response
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:1904248 ! regulation of age-related resistance
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0090644 ! age-related resistance
relationship: negatively_regulates GO:0090644 ! age-related resistance
created_by: tb
creation_date: 2015-05-19T20:20:05Z

[Term]
id: GO:1904250
name: positive regulation of age-related resistance
namespace: biological_process
def: "Any process that activates or increases the extent of age-related resistance." [GO_REF:0000058, GOC:TermGenie, PMID:19694953]
synonym: "activation of adult seedling resistance" NARROW [GOC:TermGenie]
synonym: "activation of age-related resistance" NARROW [GOC:TermGenie]
synonym: "activation of ARR" NARROW [GOC:TermGenie]
synonym: "activation of flowering-induced resistance" NARROW [GOC:TermGenie]
synonym: "activation of mature seedling resistance" NARROW [GOC:TermGenie]
synonym: "activation of senescence-induced resistance" NARROW [GOC:TermGenie]
synonym: "positive regulation of adult seedling resistance" NARROW [GOC:TermGenie]
synonym: "positive regulation of ARR" EXACT [GOC:TermGenie]
synonym: "positive regulation of flowering-induced resistance" NARROW [GOC:TermGenie]
synonym: "positive regulation of mature seedling resistance" NARROW [GOC:TermGenie]
synonym: "positive regulation of senescence-induced resistance" NARROW [GOC:TermGenie]
synonym: "up regulation of adult seedling resistance" NARROW [GOC:TermGenie]
synonym: "up regulation of age-related resistance" EXACT [GOC:TermGenie]
synonym: "up regulation of ARR" EXACT [GOC:TermGenie]
synonym: "up regulation of flowering-induced resistance" NARROW [GOC:TermGenie]
synonym: "up regulation of mature seedling resistance" NARROW [GOC:TermGenie]
synonym: "up regulation of senescence-induced resistance" NARROW [GOC:TermGenie]
synonym: "up-regulation of adult seedling resistance" NARROW [GOC:TermGenie]
synonym: "up-regulation of age-related resistance" EXACT [GOC:TermGenie]
synonym: "up-regulation of ARR" EXACT [GOC:TermGenie]
synonym: "up-regulation of flowering-induced resistance" NARROW [GOC:TermGenie]
synonym: "up-regulation of mature seedling resistance" NARROW [GOC:TermGenie]
synonym: "up-regulation of senescence-induced resistance" NARROW [GOC:TermGenie]
synonym: "upregulation of adult seedling resistance" NARROW [GOC:TermGenie]
synonym: "upregulation of age-related resistance" EXACT [GOC:TermGenie]
synonym: "upregulation of ARR" EXACT [GOC:TermGenie]
synonym: "upregulation of flowering-induced resistance" NARROW [GOC:TermGenie]
synonym: "upregulation of mature seedling resistance" NARROW [GOC:TermGenie]
synonym: "upregulation of senescence-induced resistance" NARROW [GOC:TermGenie]
is_a: GO:0045089 ! positive regulation of innate immune response
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:1904248 ! regulation of age-related resistance
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0090644 ! age-related resistance
relationship: positively_regulates GO:0090644 ! age-related resistance
created_by: tb
creation_date: 2015-05-19T20:20:11Z

[Term]
id: GO:1904251
name: regulation of bile acid metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of bile acid metabolic process." [GO_REF:0000058, GOC:bf, GOC:TermGenie]
synonym: "regulation of bile acid metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019218 ! regulation of steroid metabolic process
is_a: GO:0031323 ! regulation of cellular metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008206 ! bile acid metabolic process
relationship: regulates GO:0008206 ! bile acid metabolic process
created_by: bf
creation_date: 2015-05-20T11:04:28Z

[Term]
id: GO:1904252
name: negative regulation of bile acid metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of bile acid metabolic process." [GO_REF:0000058, GOC:bf, GOC:TermGenie]
synonym: "down regulation of bile acid metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of bile acid metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of bile acid metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of bile acid metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of bile acid metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of bile acid metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of bile acid metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of bile acid metabolism" NARROW [GOC:TermGenie]
synonym: "negative regulation of bile acid metabolism" EXACT [GOC:TermGenie]
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0045939 ! negative regulation of steroid metabolic process
is_a: GO:1904251 ! regulation of bile acid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008206 ! bile acid metabolic process
relationship: negatively_regulates GO:0008206 ! bile acid metabolic process
created_by: bf
creation_date: 2015-05-20T11:04:35Z

[Term]
id: GO:1904253
name: positive regulation of bile acid metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of bile acid metabolic process." [GO_REF:0000058, GOC:bf, GOC:TermGenie]
synonym: "activation of bile acid metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of bile acid metabolism" NARROW [GOC:TermGenie]
synonym: "positive regulation of bile acid metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of bile acid metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of bile acid metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of bile acid metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of bile acid metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of bile acid metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of bile acid metabolism" EXACT [GOC:TermGenie]
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0045940 ! positive regulation of steroid metabolic process
is_a: GO:1904251 ! regulation of bile acid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008206 ! bile acid metabolic process
relationship: positively_regulates GO:0008206 ! bile acid metabolic process
created_by: bf
creation_date: 2015-05-20T11:04:40Z

[Term]
id: GO:1904254
name: regulation of iron channel activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of iron channel activity." [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:15514116]
synonym: "regulation of iron cation channel activity" EXACT [GOC:TermGenie]
synonym: "regulation of iron-specific channel activity" EXACT [GOC:TermGenie]
is_a: GO:0034759 ! regulation of iron ion transmembrane transport
is_a: GO:2001257 ! regulation of cation channel activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097689 ! iron channel activity
relationship: regulates GO:0097689 ! iron channel activity
created_by: kom
creation_date: 2015-05-20T14:05:00Z

[Term]
id: GO:1904255
name: negative regulation of iron channel activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of iron channel activity." [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:15514116]
synonym: "down regulation of iron cation channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of iron channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of iron-specific channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of iron cation channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of iron channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of iron-specific channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of iron cation channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of iron channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of iron-specific channel activity" EXACT [GOC:TermGenie]
synonym: "inhibition of iron cation channel activity" NARROW [GOC:TermGenie]
synonym: "inhibition of iron channel activity" NARROW [GOC:TermGenie]
synonym: "inhibition of iron-specific channel activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of iron cation channel activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of iron-specific channel activity" EXACT [GOC:TermGenie]
is_a: GO:0034760 ! negative regulation of iron ion transmembrane transport
is_a: GO:1904254 ! regulation of iron channel activity
is_a: GO:2001258 ! negative regulation of cation channel activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097689 ! iron channel activity
relationship: negatively_regulates GO:0097689 ! iron channel activity
created_by: kom
creation_date: 2015-05-20T14:05:06Z

[Term]
id: GO:1904256
name: positive regulation of iron channel activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of iron channel activity." [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:15514116]
synonym: "activation of iron cation channel activity" NARROW [GOC:TermGenie]
synonym: "activation of iron channel activity" NARROW [GOC:TermGenie]
synonym: "activation of iron-specific channel activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of iron cation channel activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of iron-specific channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of iron cation channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of iron channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of iron-specific channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of iron cation channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of iron channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of iron-specific channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of iron cation channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of iron channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of iron-specific channel activity" EXACT [GOC:TermGenie]
is_a: GO:0034761 ! positive regulation of iron ion transmembrane transport
is_a: GO:1904254 ! regulation of iron channel activity
is_a: GO:2001259 ! positive regulation of cation channel activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097689 ! iron channel activity
relationship: positively_regulates GO:0097689 ! iron channel activity
created_by: kom
creation_date: 2015-05-20T14:05:12Z

[Term]
id: GO:1904257
name: zinc II ion import across Golgi membrane
namespace: biological_process
def: "The directed import of zinc(2+) from the cytosol across the Golgi membrane into the Golgi apparatus." [GO_REF:0000075, GOC:TermGenie, PMID:25732056]
comment: This term covers zinc(2+) import *across* the Golgi membrane through a channel or pore. It does not cover import via vesicle fusion with Golgi membrane, as in this case transport does not involve crossing the membrane.
synonym: "zinc(2+) import across Golgi membrane" EXACT []
is_a: GO:0071578 ! zinc II ion transmembrane import
created_by: tb
creation_date: 2015-05-20T19:56:18Z

[Term]
id: GO:1904258
name: nuclear dicing body assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a nuclear dicing body." [GO_REF:0000079, GOC:TermGenie, PMID:25902521]
synonym: "D body assembly" EXACT [GOC:TermGenie]
synonym: "D body formation" EXACT [GOC:TermGenie]
synonym: "nuclear dicing body formation" EXACT [GOC:TermGenie]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0030575 ! nuclear body organization
created_by: lr
creation_date: 2015-05-20T20:48:07Z

[Term]
id: GO:1904259
name: regulation of basement membrane assembly involved in embryonic body morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of basement membrane assembly involved in embryonic body morphogenesis." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23940118]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0045995 ! regulation of embryonic development
is_a: GO:1901201 ! regulation of extracellular matrix assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:2001197 ! basement membrane assembly involved in embryonic body morphogenesis
relationship: regulates GO:2001197 ! basement membrane assembly involved in embryonic body morphogenesis
created_by: als
creation_date: 2015-05-21T09:20:43Z

[Term]
id: GO:1904260
name: negative regulation of basement membrane assembly involved in embryonic body morphogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of basement membrane assembly involved in embryonic body morphogenesis." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23940118]
synonym: "down regulation of basement membrane assembly involved in embryonic body morphogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of basement membrane assembly involved in embryonic body morphogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of basement membrane assembly involved in embryonic body morphogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of basement membrane assembly involved in embryonic body morphogenesis" NARROW [GOC:TermGenie]
is_a: GO:0045992 ! negative regulation of embryonic development
is_a: GO:1901202 ! negative regulation of extracellular matrix assembly
is_a: GO:1904259 ! regulation of basement membrane assembly involved in embryonic body morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:2001197 ! basement membrane assembly involved in embryonic body morphogenesis
relationship: negatively_regulates GO:2001197 ! basement membrane assembly involved in embryonic body morphogenesis
created_by: als
creation_date: 2015-05-21T09:20:49Z

[Term]
id: GO:1904261
name: positive regulation of basement membrane assembly involved in embryonic body morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of basement membrane assembly involved in embryonic body morphogenesis." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23940118]
synonym: "activation of basement membrane assembly involved in embryonic body morphogenesis" NARROW [GOC:TermGenie]
synonym: "up regulation of basement membrane assembly involved in embryonic body morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of basement membrane assembly involved in embryonic body morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of basement membrane assembly involved in embryonic body morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:0040019 ! positive regulation of embryonic development
is_a: GO:1901203 ! positive regulation of extracellular matrix assembly
is_a: GO:1904259 ! regulation of basement membrane assembly involved in embryonic body morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:2001197 ! basement membrane assembly involved in embryonic body morphogenesis
relationship: positively_regulates GO:2001197 ! basement membrane assembly involved in embryonic body morphogenesis
created_by: als
creation_date: 2015-05-21T09:20:55Z

[Term]
id: GO:1904262
name: negative regulation of TORC1 signaling
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of TORC1 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:25366275]
synonym: "down regulation of TORC1 signal transduction" EXACT [GOC:TermGenie]
synonym: "down regulation of TORC1 signaling" EXACT [GOC:TermGenie]
synonym: "down-regulation of TORC1 signal transduction" EXACT [GOC:TermGenie]
synonym: "down-regulation of TORC1 signaling" EXACT [GOC:TermGenie]
synonym: "downregulation of TORC1 signal transduction" EXACT [GOC:TermGenie]
synonym: "downregulation of TORC1 signaling" EXACT [GOC:TermGenie]
synonym: "inhibition of TORC1 signal transduction" NARROW [GOC:TermGenie]
synonym: "inhibition of TORC1 signaling" NARROW [GOC:TermGenie]
synonym: "negative regulation of TORC1 signal transduction" EXACT [GOC:TermGenie]
is_a: GO:0032007 ! negative regulation of TOR signaling
is_a: GO:1903432 ! regulation of TORC1 signaling
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0038202 ! TORC1 signaling
relationship: negatively_regulates GO:0038202 ! TORC1 signaling
created_by: lb
creation_date: 2015-05-27T13:13:04Z

[Term]
id: GO:1904263
name: positive regulation of TORC1 signaling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of TORC1 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:25366275]
synonym: "activation of TORC1 signal transduction" NARROW [GOC:TermGenie]
synonym: "activation of TORC1 signaling" NARROW [GOC:TermGenie]
synonym: "positive regulation of TORC1 signal transduction" EXACT [GOC:TermGenie]
synonym: "up regulation of TORC1 signal transduction" EXACT [GOC:TermGenie]
synonym: "up regulation of TORC1 signaling" EXACT [GOC:TermGenie]
synonym: "up-regulation of TORC1 signal transduction" EXACT [GOC:TermGenie]
synonym: "up-regulation of TORC1 signaling" EXACT [GOC:TermGenie]
synonym: "upregulation of TORC1 signal transduction" EXACT [GOC:TermGenie]
synonym: "upregulation of TORC1 signaling" EXACT [GOC:TermGenie]
is_a: GO:0032008 ! positive regulation of TOR signaling
is_a: GO:1903432 ! regulation of TORC1 signaling
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0038202 ! TORC1 signaling
relationship: positively_regulates GO:0038202 ! TORC1 signaling
created_by: lb
creation_date: 2015-05-27T13:13:10Z

[Term]
id: GO:1904264
name: ubiquitin protein ligase activity involved in ERAD pathway
namespace: molecular_function
def: "Any ubiquitin protein ligase activity that is involved in the ERAD pathway (the targeting of endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome)." [GO_REF:0000061, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23990462]
synonym: "E3 involved in endoplasmic reticulum-associated degradation" RELATED [GOC:TermGenie]
synonym: "E3 involved in endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "E3 involved in ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "E3 involved in ERAD pathway" RELATED [GOC:TermGenie]
synonym: "ER-associated E3 ligase" RELATED [PMID:24019521]
synonym: "protein ubiquitination activity involved in endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "protein ubiquitination activity involved in endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "protein ubiquitination activity involved in ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "protein ubiquitination activity involved in ERAD pathway" EXACT [GOC:TermGenie]
synonym: "ubiquitin ligase activity involved in endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "ubiquitin ligase activity involved in endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin ligase activity involved in ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin ligase activity involved in ERAD pathway" EXACT [GOC:TermGenie]
synonym: "ubiquitin protein ligase activity involved in endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "ubiquitin protein ligase activity involved in endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin protein ligase activity involved in ER-associated degradation pathway" RELATED [GOC:TermGenie]
is_a: GO:0061630 ! ubiquitin protein ligase activity
intersection_of: GO:0061630 ! ubiquitin protein ligase activity
intersection_of: part_of GO:0036503 ! ERAD pathway
relationship: part_of GO:0036503 ! ERAD pathway
created_by: bf
creation_date: 2015-05-28T10:34:23Z

[Term]
id: GO:1904265
name: ubiquitin-specific protease activity involved in negative regulation of retrograde protein transport, ER to cytosol
namespace: molecular_function
def: "Any ubiquitin-specific protease activity (deubiquitinase activity) that is involved in negative regulation of retrograde protein transport, ER to cytosol." [GO_REF:0000061, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24068323]
synonym: "deubiquitinase activity involved in down regulation of protein dislocation from ER" EXACT [GOC:TermGenie]
synonym: "deubiquitinase activity involved in down regulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie]
synonym: "deubiquitinase activity involved in down regulation of retrograde protein transport, ER to cytosol" EXACT [GOC:TermGenie]
synonym: "deubiquitinase activity involved in down-regulation of protein dislocation from ER" EXACT [GOC:TermGenie]
synonym: "deubiquitinase activity involved in down-regulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie]
synonym: "deubiquitinase activity involved in down-regulation of retrograde protein transport, ER to cytosol" EXACT [GOC:TermGenie]
synonym: "deubiquitinase activity involved in downregulation of protein dislocation from ER" EXACT [GOC:TermGenie]
synonym: "deubiquitinase activity involved in downregulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie]
synonym: "deubiquitinase activity involved in downregulation of retrograde protein transport, ER to cytosol" EXACT [GOC:TermGenie]
synonym: "deubiquitinase activity involved in inhibition of protein dislocation from ER" NARROW [GOC:TermGenie]
synonym: "deubiquitinase activity involved in inhibition of retrograde protein transport, endoplasmic reticulum to cytosol" NARROW [GOC:TermGenie]
synonym: "deubiquitinase activity involved in inhibition of retrograde protein transport, ER to cytosol" NARROW [GOC:TermGenie]
synonym: "deubiquitinase activity involved in negative regulation of protein dislocation from ER" EXACT [GOC:TermGenie]
synonym: "deubiquitinase activity involved in negative regulation of protein retrotranslocation from ER" EXACT [GOC:TermGenie]
synonym: "deubiquitinase activity involved in negative regulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie]
synonym: "deubiquitinase activity involved in negative regulation of retrograde protein transport, ER to cytosol" EXACT [GOC:TermGenie]
synonym: "deubiquitinase involved in down regulation of protein dislocation from ER" EXACT [GOC:TermGenie]
synonym: "deubiquitinase involved in down regulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie]
synonym: "deubiquitinase involved in down regulation of retrograde protein transport, ER to cytosol" EXACT [GOC:TermGenie]
synonym: "deubiquitinase involved in down-regulation of protein dislocation from ER" EXACT [GOC:TermGenie]
synonym: "deubiquitinase involved in down-regulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie]
synonym: "deubiquitinase involved in down-regulation of retrograde protein transport, ER to cytosol" EXACT [GOC:TermGenie]
synonym: "deubiquitinase involved in downregulation of protein dislocation from ER" EXACT [GOC:TermGenie]
synonym: "deubiquitinase involved in downregulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie]
synonym: "deubiquitinase involved in downregulation of retrograde protein transport, ER to cytosol" EXACT [GOC:TermGenie]
synonym: "deubiquitinase involved in inhibition of protein dislocation from ER" NARROW [GOC:TermGenie]
synonym: "deubiquitinase involved in inhibition of retrograde protein transport, endoplasmic reticulum to cytosol" NARROW [GOC:TermGenie]
synonym: "deubiquitinase involved in inhibition of retrograde protein transport, ER to cytosol" NARROW [GOC:TermGenie]
synonym: "deubiquitinase involved in negative regulation of ERAD retro-translocation" EXACT [GOC:bf]
synonym: "deubiquitinase involved in negative regulation of protein dislocation from ER" EXACT [GOC:TermGenie]
synonym: "deubiquitinase involved in negative regulation of protein retrotranslocation from ER" EXACT [GOC:TermGenie]
synonym: "deubiquitinase involved in negative regulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie]
synonym: "deubiquitinase involved in negative regulation of retrograde protein transport, ER to cytosol" EXACT [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in down regulation of protein dislocation from ER" EXACT [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in down regulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in down regulation of retrograde protein transport, ER to cytosol" EXACT [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in down-regulation of protein dislocation from ER" EXACT [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in down-regulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in down-regulation of retrograde protein transport, ER to cytosol" EXACT [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in downregulation of protein dislocation from ER" EXACT [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in downregulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in downregulation of retrograde protein transport, ER to cytosol" EXACT [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in inhibition of protein dislocation from ER" NARROW [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in inhibition of retrograde protein transport, endoplasmic reticulum to cytosol" NARROW [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in inhibition of retrograde protein transport, ER to cytosol" NARROW [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in negative regulation of protein dislocation from ER" EXACT [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in negative regulation of protein retrotranslocation from ER" EXACT [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in negative regulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in negative regulation of retrograde protein transport, ER to cytosol" EXACT [GOC:TermGenie]
synonym: "deubiquitylase involved in down regulation of protein dislocation from ER" EXACT [GOC:TermGenie]
synonym: "deubiquitylase involved in down regulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie]
synonym: "deubiquitylase involved in down regulation of retrograde protein transport, ER to cytosol" EXACT [GOC:TermGenie]
synonym: "deubiquitylase involved in down-regulation of protein dislocation from ER" EXACT [GOC:TermGenie]
synonym: "deubiquitylase involved in down-regulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie]
synonym: "deubiquitylase involved in down-regulation of retrograde protein transport, ER to cytosol" EXACT [GOC:TermGenie]
synonym: "deubiquitylase involved in downregulation of protein dislocation from ER" EXACT [GOC:TermGenie]
synonym: "deubiquitylase involved in downregulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie]
synonym: "deubiquitylase involved in downregulation of retrograde protein transport, ER to cytosol" EXACT [GOC:TermGenie]
synonym: "deubiquitylase involved in inhibition of protein dislocation from ER" NARROW [GOC:TermGenie]
synonym: "deubiquitylase involved in inhibition of retrograde protein transport, endoplasmic reticulum to cytosol" NARROW [GOC:TermGenie]
synonym: "deubiquitylase involved in inhibition of retrograde protein transport, ER to cytosol" NARROW [GOC:TermGenie]
synonym: "deubiquitylase involved in negative regulation of protein dislocation from ER" EXACT [GOC:TermGenie]
synonym: "deubiquitylase involved in negative regulation of protein retrotranslocation from ER" EXACT [GOC:TermGenie]
synonym: "deubiquitylase involved in negative regulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie]
synonym: "deubiquitylase involved in negative regulation of retrograde protein transport, ER to cytosol" EXACT [GOC:TermGenie]
synonym: "DUB activity involved in negative regulation of ERAD" BROAD [GOC:bf]
synonym: "ubiquitin C-terminal hydrolase activity involved in down regulation of protein dislocation from ER" EXACT [GOC:TermGenie]
synonym: "ubiquitin C-terminal hydrolase activity involved in down regulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie]
synonym: "ubiquitin C-terminal hydrolase activity involved in down regulation of retrograde protein transport, ER to cytosol" EXACT [GOC:TermGenie]
synonym: "ubiquitin C-terminal hydrolase activity involved in down-regulation of protein dislocation from ER" EXACT [GOC:TermGenie]
synonym: "ubiquitin C-terminal hydrolase activity involved in down-regulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie]
synonym: "ubiquitin C-terminal hydrolase activity involved in down-regulation of retrograde protein transport, ER to cytosol" EXACT [GOC:TermGenie]
synonym: "ubiquitin C-terminal hydrolase activity involved in downregulation of protein dislocation from ER" EXACT [GOC:TermGenie]
synonym: "ubiquitin C-terminal hydrolase activity involved in downregulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie]
synonym: "ubiquitin C-terminal hydrolase activity involved in downregulation of retrograde protein transport, ER to cytosol" EXACT [GOC:TermGenie]
synonym: "ubiquitin C-terminal hydrolase activity involved in inhibition of protein dislocation from ER" NARROW [GOC:TermGenie]
synonym: "ubiquitin C-terminal hydrolase activity involved in inhibition of retrograde protein transport, endoplasmic reticulum to cytosol" NARROW [GOC:TermGenie]
synonym: "ubiquitin C-terminal hydrolase activity involved in inhibition of retrograde protein transport, ER to cytosol" NARROW [GOC:TermGenie]
synonym: "ubiquitin C-terminal hydrolase activity involved in negative regulation of protein dislocation from ER" EXACT [GOC:TermGenie]
synonym: "ubiquitin C-terminal hydrolase activity involved in negative regulation of protein retrotranslocation from ER" EXACT [GOC:TermGenie]
synonym: "ubiquitin C-terminal hydrolase activity involved in negative regulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie]
synonym: "ubiquitin C-terminal hydrolase activity involved in negative regulation of retrograde protein transport, ER to cytosol" EXACT [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in down regulation of protein dislocation from ER" EXACT [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in down regulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in down regulation of retrograde protein transport, ER to cytosol" EXACT [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in down-regulation of protein dislocation from ER" EXACT [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in down-regulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in down-regulation of retrograde protein transport, ER to cytosol" EXACT [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in downregulation of protein dislocation from ER" EXACT [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in downregulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in downregulation of retrograde protein transport, ER to cytosol" EXACT [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in inhibition of protein dislocation from ER" NARROW [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in inhibition of retrograde protein transport, endoplasmic reticulum to cytosol" NARROW [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in inhibition of retrograde protein transport, ER to cytosol" NARROW [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in negative regulation of protein dislocation from ER" EXACT [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in negative regulation of protein retrotranslocation from ER" EXACT [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in negative regulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in negative regulation of retrograde protein transport, ER to cytosol" EXACT [GOC:TermGenie]
synonym: "ubiquitin-specific protease activity involved in down regulation of protein dislocation from ER" EXACT [GOC:TermGenie]
synonym: "ubiquitin-specific protease activity involved in down regulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie]
synonym: "ubiquitin-specific protease activity involved in down regulation of retrograde protein transport, ER to cytosol" EXACT [GOC:TermGenie]
synonym: "ubiquitin-specific protease activity involved in down-regulation of protein dislocation from ER" EXACT [GOC:TermGenie]
synonym: "ubiquitin-specific protease activity involved in down-regulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie]
synonym: "ubiquitin-specific protease activity involved in down-regulation of retrograde protein transport, ER to cytosol" EXACT [GOC:TermGenie]
synonym: "ubiquitin-specific protease activity involved in downregulation of protein dislocation from ER" EXACT [GOC:TermGenie]
synonym: "ubiquitin-specific protease activity involved in downregulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie]
synonym: "ubiquitin-specific protease activity involved in downregulation of retrograde protein transport, ER to cytosol" EXACT [GOC:TermGenie]
synonym: "ubiquitin-specific protease activity involved in inhibition of protein dislocation from ER" NARROW [GOC:TermGenie]
synonym: "ubiquitin-specific protease activity involved in inhibition of retrograde protein transport, endoplasmic reticulum to cytosol" NARROW [GOC:TermGenie]
synonym: "ubiquitin-specific protease activity involved in inhibition of retrograde protein transport, ER to cytosol" NARROW [GOC:TermGenie]
synonym: "ubiquitin-specific protease activity involved in negative regulation of protein dislocation from ER" EXACT [GOC:TermGenie]
synonym: "ubiquitin-specific protease activity involved in negative regulation of protein retrotranslocation from ER" EXACT [GOC:TermGenie]
synonym: "ubiquitin-specific protease activity involved in negative regulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie]
synonym: "UBP involved in down regulation of protein dislocation from ER" NARROW [GOC:TermGenie]
synonym: "UBP involved in down regulation of retrograde protein transport, endoplasmic reticulum to cytosol" NARROW [GOC:TermGenie]
synonym: "UBP involved in down regulation of retrograde protein transport, ER to cytosol" NARROW [GOC:TermGenie]
synonym: "UBP involved in down-regulation of protein dislocation from ER" NARROW [GOC:TermGenie]
synonym: "UBP involved in down-regulation of retrograde protein transport, endoplasmic reticulum to cytosol" NARROW [GOC:TermGenie]
synonym: "UBP involved in down-regulation of retrograde protein transport, ER to cytosol" NARROW [GOC:TermGenie]
synonym: "UBP involved in downregulation of protein dislocation from ER" NARROW [GOC:TermGenie]
synonym: "UBP involved in downregulation of retrograde protein transport, endoplasmic reticulum to cytosol" NARROW [GOC:TermGenie]
synonym: "UBP involved in downregulation of retrograde protein transport, ER to cytosol" NARROW [GOC:TermGenie]
synonym: "UBP involved in inhibition of protein dislocation from ER" NARROW [GOC:TermGenie]
synonym: "UBP involved in inhibition of retrograde protein transport, endoplasmic reticulum to cytosol" NARROW [GOC:TermGenie]
synonym: "UBP involved in inhibition of retrograde protein transport, ER to cytosol" NARROW [GOC:TermGenie]
synonym: "UBP involved in negative regulation of protein dislocation from ER" NARROW [GOC:TermGenie]
synonym: "UBP involved in negative regulation of protein retrotranslocation from ER" NARROW [GOC:TermGenie]
synonym: "UBP involved in negative regulation of retrograde protein transport, endoplasmic reticulum to cytosol" NARROW [GOC:TermGenie]
synonym: "UBP involved in negative regulation of retrograde protein transport, ER to cytosol" NARROW [GOC:TermGenie]
synonym: "UCH2 involved in down regulation of protein dislocation from ER" NARROW [GOC:TermGenie]
synonym: "UCH2 involved in down regulation of retrograde protein transport, endoplasmic reticulum to cytosol" NARROW [GOC:TermGenie]
synonym: "UCH2 involved in down regulation of retrograde protein transport, ER to cytosol" NARROW [GOC:TermGenie]
synonym: "UCH2 involved in down-regulation of protein dislocation from ER" NARROW [GOC:TermGenie]
synonym: "UCH2 involved in down-regulation of retrograde protein transport, endoplasmic reticulum to cytosol" NARROW [GOC:TermGenie]
synonym: "UCH2 involved in down-regulation of retrograde protein transport, ER to cytosol" NARROW [GOC:TermGenie]
synonym: "UCH2 involved in downregulation of protein dislocation from ER" NARROW [GOC:TermGenie]
synonym: "UCH2 involved in downregulation of retrograde protein transport, endoplasmic reticulum to cytosol" NARROW [GOC:TermGenie]
synonym: "UCH2 involved in downregulation of retrograde protein transport, ER to cytosol" NARROW [GOC:TermGenie]
synonym: "UCH2 involved in inhibition of protein dislocation from ER" NARROW [GOC:TermGenie]
synonym: "UCH2 involved in inhibition of retrograde protein transport, endoplasmic reticulum to cytosol" NARROW [GOC:TermGenie]
synonym: "UCH2 involved in inhibition of retrograde protein transport, ER to cytosol" NARROW [GOC:TermGenie]
synonym: "UCH2 involved in negative regulation of protein dislocation from ER" NARROW [GOC:TermGenie]
synonym: "UCH2 involved in negative regulation of protein retrotranslocation from ER" NARROW [GOC:TermGenie]
synonym: "UCH2 involved in negative regulation of retrograde protein transport, endoplasmic reticulum to cytosol" NARROW [GOC:TermGenie]
synonym: "UCH2 involved in negative regulation of retrograde protein transport, ER to cytosol" NARROW [GOC:TermGenie]
is_a: GO:1904455 ! ubiquitin-specific protease activity involved in negative regulation of ERAD pathway
intersection_of: GO:0101005 ! ubiquitinyl hydrolase activity
intersection_of: part_of GO:1904153 ! negative regulation of retrograde protein transport, ER to cytosol
relationship: part_of GO:1904153 ! negative regulation of retrograde protein transport, ER to cytosol
created_by: bf
creation_date: 2015-05-28T10:52:14Z

[Term]
id: GO:1904266
name: regulation of Schwann cell chemotaxis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Schwann cell chemotaxis." [GO_REF:0000058, GOC:TermGenie, PMID:16203995]
is_a: GO:0050920 ! regulation of chemotaxis
is_a: GO:1900147 ! regulation of Schwann cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990751 ! Schwann cell chemotaxis
relationship: regulates GO:1990751 ! Schwann cell chemotaxis
created_by: sl
creation_date: 2015-05-28T17:47:41Z

[Term]
id: GO:1904267
name: negative regulation of Schwann cell chemotaxis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of Schwann cell chemotaxis." [GO_REF:0000058, GOC:TermGenie, PMID:16203995]
synonym: "down regulation of Schwann cell chemotaxis" EXACT [GOC:TermGenie]
synonym: "down-regulation of Schwann cell chemotaxis" EXACT [GOC:TermGenie]
synonym: "downregulation of Schwann cell chemotaxis" EXACT [GOC:TermGenie]
synonym: "inhibition of Schwann cell chemotaxis" NARROW [GOC:TermGenie]
is_a: GO:0050922 ! negative regulation of chemotaxis
is_a: GO:1900148 ! negative regulation of Schwann cell migration
is_a: GO:1904266 ! regulation of Schwann cell chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990751 ! Schwann cell chemotaxis
relationship: negatively_regulates GO:1990751 ! Schwann cell chemotaxis
created_by: sl
creation_date: 2015-05-28T17:47:48Z

[Term]
id: GO:1904268
name: positive regulation of Schwann cell chemotaxis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of Schwann cell chemotaxis." [GO_REF:0000058, GOC:TermGenie, PMID:16203995]
synonym: "activation of Schwann cell chemotaxis" NARROW [GOC:TermGenie]
synonym: "up regulation of Schwann cell chemotaxis" EXACT [GOC:TermGenie]
synonym: "up-regulation of Schwann cell chemotaxis" EXACT [GOC:TermGenie]
synonym: "upregulation of Schwann cell chemotaxis" EXACT [GOC:TermGenie]
is_a: GO:0050921 ! positive regulation of chemotaxis
is_a: GO:1900149 ! positive regulation of Schwann cell migration
is_a: GO:1904266 ! regulation of Schwann cell chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990751 ! Schwann cell chemotaxis
relationship: positively_regulates GO:1990751 ! Schwann cell chemotaxis
created_by: sl
creation_date: 2015-05-28T17:47:55Z

[Term]
id: GO:1904269
name: cell leading edge cell cortex
namespace: cellular_component
def: "The cell cortex of the leading edge of a cell." [GO_REF:0000064, GOC:kmv, GOC:TermGenie, PMID:25843030]
synonym: "cell cortex of cell leading edge" EXACT [GOC:TermGenie]
synonym: "cell cortex of front of cell" EXACT [GOC:TermGenie]
synonym: "cell cortex of leading edge of cell" EXACT [GOC:TermGenie]
synonym: "cell periphery of cell leading edge" RELATED [GOC:TermGenie]
synonym: "cell periphery of front of cell" RELATED [GOC:TermGenie]
synonym: "cell periphery of leading edge of cell" RELATED [GOC:TermGenie]
synonym: "peripheral cytoplasm of cell leading edge" RELATED [GOC:TermGenie]
synonym: "peripheral cytoplasm of front of cell" RELATED [GOC:TermGenie]
synonym: "peripheral cytoplasm of leading edge of cell" RELATED [GOC:TermGenie]
is_a: GO:0099738 ! cell cortex region
intersection_of: GO:0099738 ! cell cortex region
intersection_of: part_of GO:0031252 ! cell leading edge
relationship: part_of GO:0031252 ! cell leading edge
created_by: kmv
creation_date: 2015-05-28T19:16:03Z

[Term]
id: GO:1904270
name: pyroptosome complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a pyroptosome complex." [GO_REF:0000079, GOC:TermGenie, PMID:17964261]
synonym: "ASC pyroptosome assembly" EXACT [GOC:TermGenie]
synonym: "ASC pyroptosome formation" EXACT [GOC:TermGenie]
synonym: "pyroptosome complex formation" EXACT [GOC:TermGenie]
is_a: GO:0006461 ! protein complex assembly
created_by: lb
creation_date: 2015-05-29T08:25:45Z

[Term]
id: GO:1904271
name: L-proline import across plasma membrane
namespace: biological_process
def: "The directed movement of L-proline from outside of a cell into the cytoplasmic compartment." [GO_REF:0000075, GOC:kmv, GOC:TermGenie, PMID:21097500]
is_a: GO:0089718 ! amino acid import across plasma membrane
is_a: GO:1902825 ! proline import into cell
is_a: GO:1903809 ! L-proline import into cell
is_a: GO:1904555 ! L-proline transmembrane transport
created_by: kmv
creation_date: 2015-05-29T13:39:20Z

[Term]
id: GO:1904272
name: L-tryptophan import across plasma membrane
namespace: biological_process
def: "The directed movement of L-tryptophan from outside of a cell into the cytoplasmic compartment." [GO_REF:0000075, GOC:kmv, GOC:TermGenie, PMID:21097500]
is_a: GO:0043092 ! L-amino acid import
is_a: GO:0089718 ! amino acid import across plasma membrane
is_a: GO:1904556 ! L-tryptophan transmembrane transport
created_by: kmv
creation_date: 2015-05-29T13:39:27Z

[Term]
id: GO:1904273
name: L-alanine import across plasma membrane
namespace: biological_process
def: "The directed movement of L-alanine from outside of a cell into the cytoplasmic compartment." [GO_REF:0000075, GOC:kmv, GOC:TermGenie, PMID:21097500]
is_a: GO:0043092 ! L-amino acid import
is_a: GO:0089718 ! amino acid import across plasma membrane
is_a: GO:1904557 ! L-alanine transmembrane transport
created_by: kmv
creation_date: 2015-05-29T13:39:34Z

[Term]
id: GO:1904274
name: tricellular tight junction assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a tricellular tight junction." [GO_REF:0000079, GOC:mr, GOC:TermGenie, PMID:22640933, PMID:25097825, PMID:4203962]
synonym: "tricellular tight junction formation" EXACT [GOC:TermGenie]
is_a: GO:0007043 ! cell-cell junction assembly
created_by: mr
creation_date: 2015-05-29T16:31:00Z

[Term]
id: GO:1904275
name: tricellular tight junction disassembly
namespace: biological_process
def: "The disaggregation of a tricellular tight junction into its constituent components." [GO_REF:0000079, GOC:mr, GOC:TermGenie, PMID:22640933, PMID:25097825, PMID:4203962]
is_a: GO:1905071 ! occluding junction disassembly
created_by: mr
creation_date: 2015-05-29T16:31:06Z

[Term]
id: GO:1904276
name: regulation of wax biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of wax biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:24692420]
synonym: "regulation of wax anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of wax biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of wax formation" EXACT [GOC:TermGenie]
synonym: "regulation of wax synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009889 ! regulation of biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010025 ! wax biosynthetic process
relationship: regulates GO:0010025 ! wax biosynthetic process
created_by: tb
creation_date: 2015-06-03T17:20:06Z

[Term]
id: GO:1904277
name: negative regulation of wax biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of wax biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:24692420]
synonym: "down regulation of wax anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of wax biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of wax biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of wax formation" EXACT [GOC:TermGenie]
synonym: "down regulation of wax synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of wax anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of wax biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of wax biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of wax formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of wax synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of wax anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of wax biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of wax biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of wax formation" EXACT [GOC:TermGenie]
synonym: "downregulation of wax synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of wax anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of wax biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of wax biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of wax formation" NARROW [GOC:TermGenie]
synonym: "inhibition of wax synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of wax anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of wax biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of wax formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of wax synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:1904276 ! regulation of wax biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010025 ! wax biosynthetic process
relationship: negatively_regulates GO:0010025 ! wax biosynthetic process
created_by: tb
creation_date: 2015-06-03T17:20:13Z

[Term]
id: GO:1904278
name: positive regulation of wax biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of wax biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:24692420]
synonym: "activation of wax anabolism" NARROW [GOC:TermGenie]
synonym: "activation of wax biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of wax biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of wax formation" NARROW [GOC:TermGenie]
synonym: "activation of wax synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of wax anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of wax biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of wax formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of wax synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of wax anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of wax biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of wax biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of wax formation" EXACT [GOC:TermGenie]
synonym: "up regulation of wax synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of wax anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of wax biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of wax biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of wax formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of wax synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of wax anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of wax biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of wax biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of wax formation" EXACT [GOC:TermGenie]
synonym: "upregulation of wax synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:1904276 ! regulation of wax biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010025 ! wax biosynthetic process
relationship: positively_regulates GO:0010025 ! wax biosynthetic process
created_by: tb
creation_date: 2015-06-03T17:20:19Z

[Term]
id: GO:1904279
name: regulation of transcription from RNA polymerase V promoter
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from RNA polymerase V promoter." [GO_REF:0000058, GOC:TermGenie, PMID:24726328]
synonym: "regulation of transcription from RNA pol V promoter" EXACT [GOC:TermGenie]
is_a: GO:0006355 ! regulation of transcription, DNA-templated
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001060 ! transcription from RNA polymerase V promoter
relationship: regulates GO:0001060 ! transcription from RNA polymerase V promoter
created_by: tb
creation_date: 2015-06-03T22:01:47Z

[Term]
id: GO:1904280
name: negative regulation of transcription from RNA polymerase V promoter
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription from RNA polymerase V promoter." [GO_REF:0000058, GOC:TermGenie, PMID:24726328]
synonym: "down regulation of transcription from RNA pol V promoter" EXACT [GOC:TermGenie]
synonym: "down regulation of transcription from RNA polymerase V promoter" EXACT [GOC:TermGenie]
synonym: "down-regulation of transcription from RNA pol V promoter" EXACT [GOC:TermGenie]
synonym: "down-regulation of transcription from RNA polymerase V promoter" EXACT [GOC:TermGenie]
synonym: "downregulation of transcription from RNA pol V promoter" EXACT [GOC:TermGenie]
synonym: "downregulation of transcription from RNA polymerase V promoter" EXACT [GOC:TermGenie]
synonym: "inhibition of transcription from RNA pol V promoter" NARROW [GOC:TermGenie]
synonym: "inhibition of transcription from RNA polymerase V promoter" NARROW [GOC:TermGenie]
synonym: "negative regulation of transcription from RNA pol V promoter" EXACT [GOC:TermGenie]
is_a: GO:0045892 ! negative regulation of transcription, DNA-templated
is_a: GO:1904279 ! regulation of transcription from RNA polymerase V promoter
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001060 ! transcription from RNA polymerase V promoter
relationship: negatively_regulates GO:0001060 ! transcription from RNA polymerase V promoter
created_by: tb
creation_date: 2015-06-03T22:01:54Z

[Term]
id: GO:1904281
name: positive regulation of transcription from RNA polymerase V promoter
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transcription from RNA polymerase V promoter." [GO_REF:0000058, GOC:TermGenie, PMID:24726328]
synonym: "activation of transcription from RNA pol V promoter" NARROW [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase V promoter" NARROW [GOC:TermGenie]
synonym: "positive regulation of transcription from RNA pol V promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of transcription from RNA pol V promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase V promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA pol V promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase V promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of transcription from RNA pol V promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase V promoter" EXACT [GOC:TermGenie]
is_a: GO:0045893 ! positive regulation of transcription, DNA-templated
is_a: GO:1904279 ! regulation of transcription from RNA polymerase V promoter
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001060 ! transcription from RNA polymerase V promoter
relationship: positively_regulates GO:0001060 ! transcription from RNA polymerase V promoter
created_by: tb
creation_date: 2015-06-03T22:02:00Z

[Term]
id: GO:1904282
name: regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of antigen processing and presentation of endogenous peptide antigen via MHC class I." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:24643698]
synonym: "regulation of antigen presentation, endogenous peptide antigen" BROAD [GOC:TermGenie]
synonym: "regulation of antigen processing, endogenous antigen via major histocompatibility complex class I" BROAD [GOC:TermGenie]
synonym: "regulation of antigen processing, endogenous antigen via MHC class I" BROAD [GOC:TermGenie]
synonym: "regulation of endogenous peptide antigen processing and presentation via MHC class I" EXACT [GOC:TermGenie]
is_a: GO:0002589 ! regulation of antigen processing and presentation of peptide antigen via MHC class I
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019885 ! antigen processing and presentation of endogenous peptide antigen via MHC class I
relationship: regulates GO:0019885 ! antigen processing and presentation of endogenous peptide antigen via MHC class I
created_by: rl
creation_date: 2015-06-04T12:05:28Z

[Term]
id: GO:1904283
name: negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of antigen processing and presentation of endogenous peptide antigen via MHC class I." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:24643698]
synonym: "down regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I" EXACT [GOC:TermGenie]
synonym: "down regulation of endogenous peptide antigen processing and presentation via MHC class I" EXACT [GOC:TermGenie]
synonym: "down-regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I" EXACT [GOC:TermGenie]
synonym: "down-regulation of endogenous peptide antigen processing and presentation via MHC class I" EXACT [GOC:TermGenie]
synonym: "downregulation of antigen processing and presentation of endogenous peptide antigen via MHC class I" EXACT [GOC:TermGenie]
synonym: "downregulation of endogenous peptide antigen processing and presentation via MHC class I" EXACT [GOC:TermGenie]
synonym: "inhibition of antigen processing and presentation of endogenous peptide antigen via MHC class I" NARROW [GOC:TermGenie]
synonym: "inhibition of endogenous peptide antigen processing and presentation via MHC class I" NARROW [GOC:TermGenie]
synonym: "negative regulation of endogenous peptide antigen processing and presentation via MHC class I" EXACT [GOC:TermGenie]
is_a: GO:0002590 ! negative regulation of antigen processing and presentation of peptide antigen via MHC class I
is_a: GO:1904282 ! regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019885 ! antigen processing and presentation of endogenous peptide antigen via MHC class I
relationship: negatively_regulates GO:0019885 ! antigen processing and presentation of endogenous peptide antigen via MHC class I
created_by: rl
creation_date: 2015-06-04T12:05:34Z

[Term]
id: GO:1904284
name: positive regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of antigen processing and presentation of endogenous peptide antigen via MHC class I." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:24643698]
synonym: "activation of antigen processing and presentation of endogenous peptide antigen via MHC class I" NARROW [GOC:TermGenie]
synonym: "activation of endogenous peptide antigen processing and presentation via MHC class I" NARROW [GOC:TermGenie]
synonym: "positive regulation of endogenous peptide antigen processing and presentation via MHC class I" EXACT [GOC:TermGenie]
synonym: "up regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I" EXACT [GOC:TermGenie]
synonym: "up regulation of endogenous peptide antigen processing and presentation via MHC class I" EXACT [GOC:TermGenie]
synonym: "up-regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I" EXACT [GOC:TermGenie]
synonym: "up-regulation of endogenous peptide antigen processing and presentation via MHC class I" EXACT [GOC:TermGenie]
synonym: "upregulation of antigen processing and presentation of endogenous peptide antigen via MHC class I" EXACT [GOC:TermGenie]
synonym: "upregulation of endogenous peptide antigen processing and presentation via MHC class I" EXACT [GOC:TermGenie]
is_a: GO:0002591 ! positive regulation of antigen processing and presentation of peptide antigen via MHC class I
is_a: GO:1904282 ! regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0019885 ! antigen processing and presentation of endogenous peptide antigen via MHC class I
relationship: positively_regulates GO:0019885 ! antigen processing and presentation of endogenous peptide antigen via MHC class I
created_by: rl
creation_date: 2015-06-04T12:05:49Z

[Term]
id: GO:1904285
name: regulation of protein-pyridoxal-5-phosphate linkage
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein-pyridoxal-5-phosphate linkage." [GO_REF:0000058, GOC:TermGenie, PMID:25957689]
is_a: GO:0031399 ! regulation of protein modification process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0018352 ! protein-pyridoxal-5-phosphate linkage
relationship: regulates GO:0018352 ! protein-pyridoxal-5-phosphate linkage
created_by: mcc
creation_date: 2015-06-05T17:21:14Z

[Term]
id: GO:1904286
name: negative regulation of protein-pyridoxal-5-phosphate linkage
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein-pyridoxal-5-phosphate linkage." [GO_REF:0000058, GOC:TermGenie, PMID:25957689]
synonym: "down regulation of protein-pyridoxal-5-phosphate linkage" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein-pyridoxal-5-phosphate linkage" EXACT [GOC:TermGenie]
synonym: "downregulation of protein-pyridoxal-5-phosphate linkage" EXACT [GOC:TermGenie]
synonym: "inhibition of protein-pyridoxal-5-phosphate linkage" NARROW [GOC:TermGenie]
is_a: GO:0031400 ! negative regulation of protein modification process
is_a: GO:1904285 ! regulation of protein-pyridoxal-5-phosphate linkage
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0018352 ! protein-pyridoxal-5-phosphate linkage
relationship: negatively_regulates GO:0018352 ! protein-pyridoxal-5-phosphate linkage
created_by: mcc
creation_date: 2015-06-05T17:21:21Z

[Term]
id: GO:1904287
name: positive regulation of protein-pyridoxal-5-phosphate linkage
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein-pyridoxal-5-phosphate linkage." [GO_REF:0000058, GOC:TermGenie, PMID:25957689]
synonym: "activation of protein-pyridoxal-5-phosphate linkage" NARROW [GOC:TermGenie]
synonym: "stimulation of protein-pyridoxal-5-phosphate linkage" EXACT []
synonym: "up regulation of protein-pyridoxal-5-phosphate linkage" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein-pyridoxal-5-phosphate linkage" EXACT [GOC:TermGenie]
synonym: "upregulation of protein-pyridoxal-5-phosphate linkage" EXACT [GOC:TermGenie]
is_a: GO:0031401 ! positive regulation of protein modification process
is_a: GO:1904285 ! regulation of protein-pyridoxal-5-phosphate linkage
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0018352 ! protein-pyridoxal-5-phosphate linkage
relationship: positively_regulates GO:0018352 ! protein-pyridoxal-5-phosphate linkage
created_by: mcc
creation_date: 2015-06-05T17:21:28Z

[Term]
id: GO:1904288
name: BAT3 complex binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a BAT3 complex." [GO_REF:000102, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23246001]
synonym: "Bag6 complex binding" EXACT [GOC:TermGenie]
synonym: "BAG6-UBL4A-TRC35 complex binding" EXACT [GOC:TermGenie]
synonym: "BAT3-TRC35-UBL4A complex binding" RELATED [GOC:TermGenie]
is_a: GO:0070628 ! proteasome binding
created_by: bf
creation_date: 2015-06-07T19:48:55Z

[Term]
id: GO:1904289
name: regulation of mitotic DNA damage checkpoint
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitotic DNA damage checkpoint." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:16549501]
is_a: GO:0007346 ! regulation of mitotic cell cycle
is_a: GO:2000001 ! regulation of DNA damage checkpoint
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044773 ! mitotic DNA damage checkpoint
relationship: regulates GO:0044773 ! mitotic DNA damage checkpoint
created_by: kmv
creation_date: 2015-06-09T13:03:11Z

[Term]
id: GO:1904290
name: negative regulation of mitotic DNA damage checkpoint
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic DNA damage checkpoint." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:16549501]
synonym: "down regulation of mitotic DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitotic DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "downregulation of mitotic DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "inhibition of mitotic DNA damage checkpoint" NARROW [GOC:TermGenie]
is_a: GO:0045930 ! negative regulation of mitotic cell cycle
is_a: GO:0045931 ! positive regulation of mitotic cell cycle
is_a: GO:1904289 ! regulation of mitotic DNA damage checkpoint
is_a: GO:2000002 ! negative regulation of DNA damage checkpoint
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044773 ! mitotic DNA damage checkpoint
relationship: negatively_regulates GO:0044773 ! mitotic DNA damage checkpoint
created_by: kmv
creation_date: 2015-06-09T13:03:17Z

[Term]
id: GO:1904291
name: positive regulation of mitotic DNA damage checkpoint
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitotic DNA damage checkpoint." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:16549501]
synonym: "activation of mitotic DNA damage checkpoint" NARROW [GOC:TermGenie]
synonym: "up regulation of mitotic DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitotic DNA damage checkpoint" EXACT [GOC:TermGenie]
synonym: "upregulation of mitotic DNA damage checkpoint" EXACT [GOC:TermGenie]
is_a: GO:0045931 ! positive regulation of mitotic cell cycle
is_a: GO:1904289 ! regulation of mitotic DNA damage checkpoint
is_a: GO:2000003 ! positive regulation of DNA damage checkpoint
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044773 ! mitotic DNA damage checkpoint
relationship: positively_regulates GO:0044773 ! mitotic DNA damage checkpoint
created_by: kmv
creation_date: 2015-06-09T13:03:23Z

[Term]
id: GO:1904292
name: regulation of ERAD pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ERAD pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
is_a: GO:0042176 ! regulation of protein catabolic process
is_a: GO:0080135 ! regulation of cellular response to stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0036503 ! ERAD pathway
relationship: regulates GO:0036503 ! ERAD pathway
created_by: bf
creation_date: 2015-06-09T14:44:27Z

[Term]
id: GO:1904293
name: negative regulation of ERAD pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ERAD pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22590560]
synonym: "down regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "down regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "down regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "down regulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "down-regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "down-regulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "downregulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "downregulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of endoplasmic reticulum-associated degradation" NARROW [GOC:TermGenie]
synonym: "inhibition of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "inhibition of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "inhibition of ERAD pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "negative regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
is_a: GO:0042177 ! negative regulation of protein catabolic process
is_a: GO:1903573 ! negative regulation of response to endoplasmic reticulum stress
is_a: GO:1904292 ! regulation of ERAD pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0036503 ! ERAD pathway
relationship: negatively_regulates GO:0036503 ! ERAD pathway
created_by: bf
creation_date: 2015-06-09T14:44:33Z

[Term]
id: GO:1904294
name: positive regulation of ERAD pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ERAD pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "activation of endoplasmic reticulum-associated degradation" NARROW [GOC:TermGenie]
synonym: "activation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "activation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "activation of ERAD pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "positive regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "up regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "up regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "up regulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "up-regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "up-regulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "upregulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "upregulation of ERAD pathway" EXACT [GOC:TermGenie]
is_a: GO:0045732 ! positive regulation of protein catabolic process
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1904292 ! regulation of ERAD pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0036503 ! ERAD pathway
relationship: positively_regulates GO:0036503 ! ERAD pathway
created_by: bf
creation_date: 2015-06-09T14:44:39Z

[Term]
id: GO:1904295
name: regulation of osmolarity-sensing cation channel activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of osmolarity-sensing cation channel activity." [GO_REF:0000059, GOC:TermGenie, PMID:18279313]
is_a: GO:0010469 ! regulation of receptor activity
is_a: GO:2001257 ! regulation of cation channel activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990760 ! osmolarity-sensing cation channel activity
relationship: regulates GO:1990760 ! osmolarity-sensing cation channel activity
created_by: sl
creation_date: 2015-06-09T17:35:40Z

[Term]
id: GO:1904296
name: negative regulation of osmolarity-sensing cation channel activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of osmolarity-sensing cation channel activity." [GO_REF:0000059, GOC:TermGenie, PMID:18279313]
synonym: "down regulation of osmolarity-sensing cation channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of osmolarity-sensing cation channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of osmolarity-sensing cation channel activity" EXACT [GOC:TermGenie]
synonym: "inhibition of osmolarity-sensing cation channel activity" NARROW [GOC:TermGenie]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:1904295 ! regulation of osmolarity-sensing cation channel activity
is_a: GO:2000272 ! negative regulation of receptor activity
is_a: GO:2001258 ! negative regulation of cation channel activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990760 ! osmolarity-sensing cation channel activity
relationship: negatively_regulates GO:1990760 ! osmolarity-sensing cation channel activity
created_by: sl
creation_date: 2015-06-09T17:35:46Z

[Term]
id: GO:1904297
name: positive regulation of osmolarity-sensing cation channel activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of osmolarity-sensing cation channel activity." [GO_REF:0000059, GOC:TermGenie, PMID:18279313]
synonym: "activation of osmolarity-sensing cation channel activity" NARROW [GOC:TermGenie]
synonym: "up regulation of osmolarity-sensing cation channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of osmolarity-sensing cation channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of osmolarity-sensing cation channel activity" EXACT [GOC:TermGenie]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:1904295 ! regulation of osmolarity-sensing cation channel activity
is_a: GO:2000273 ! positive regulation of receptor activity
is_a: GO:2001259 ! positive regulation of cation channel activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990760 ! osmolarity-sensing cation channel activity
relationship: positively_regulates GO:1990760 ! osmolarity-sensing cation channel activity
created_by: sl
creation_date: 2015-06-09T17:35:52Z

[Term]
id: GO:1904298
name: regulation of transcytosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcytosis." [GO_REF:0000058, GOC:TermGenie, PMID:9664076]
is_a: GO:0060627 ! regulation of vesicle-mediated transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045056 ! transcytosis
relationship: regulates GO:0045056 ! transcytosis
created_by: sl
creation_date: 2015-06-09T22:53:26Z

[Term]
id: GO:1904299
name: negative regulation of transcytosis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcytosis." [GO_REF:0000058, GOC:TermGenie, PMID:9664076]
synonym: "down regulation of transcytosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of transcytosis" EXACT [GOC:TermGenie]
synonym: "downregulation of transcytosis" EXACT [GOC:TermGenie]
synonym: "inhibition of transcytosis" NARROW [GOC:TermGenie]
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:1904298 ! regulation of transcytosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045056 ! transcytosis
relationship: negatively_regulates GO:0045056 ! transcytosis
created_by: sl
creation_date: 2015-06-09T22:53:32Z

[Term]
id: GO:1904300
name: positive regulation of transcytosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transcytosis." [GO_REF:0000058, GOC:TermGenie, PMID:9664076]
synonym: "activation of transcytosis" NARROW [GOC:TermGenie]
synonym: "up regulation of transcytosis" EXACT [GOC:TermGenie]
synonym: "up-regulation of transcytosis" EXACT [GOC:TermGenie]
synonym: "upregulation of transcytosis" EXACT [GOC:TermGenie]
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:1904298 ! regulation of transcytosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045056 ! transcytosis
relationship: positively_regulates GO:0045056 ! transcytosis
created_by: sl
creation_date: 2015-06-09T22:53:38Z

[Term]
id: GO:1904301
name: regulation of maternal process involved in parturition
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of maternal process involved in parturition." [GO_REF:0000058, GOC:TermGenie, PMID:1849751]
is_a: GO:0043900 ! regulation of multi-organism process
is_a: GO:0051239 ! regulation of multicellular organismal process
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060137 ! maternal process involved in parturition
relationship: regulates GO:0060137 ! maternal process involved in parturition
created_by: sl
creation_date: 2015-06-09T23:01:32Z

[Term]
id: GO:1904302
name: negative regulation of maternal process involved in parturition
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of maternal process involved in parturition." [GO_REF:0000058, GOC:TermGenie, PMID:1849751]
synonym: "down regulation of maternal process involved in parturition" EXACT [GOC:TermGenie]
synonym: "down-regulation of maternal process involved in parturition" EXACT [GOC:TermGenie]
synonym: "downregulation of maternal process involved in parturition" EXACT [GOC:TermGenie]
synonym: "inhibition of maternal process involved in parturition" NARROW [GOC:TermGenie]
is_a: GO:0043901 ! negative regulation of multi-organism process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1904301 ! regulation of maternal process involved in parturition
is_a: GO:2000242 ! negative regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060137 ! maternal process involved in parturition
relationship: negatively_regulates GO:0060137 ! maternal process involved in parturition
created_by: sl
creation_date: 2015-06-09T23:01:38Z

[Term]
id: GO:1904303
name: positive regulation of maternal process involved in parturition
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of maternal process involved in parturition." [GO_REF:0000058, GOC:TermGenie, PMID:1849751]
synonym: "activation of maternal process involved in parturition" NARROW [GOC:TermGenie]
synonym: "up regulation of maternal process involved in parturition" EXACT [GOC:TermGenie]
synonym: "up-regulation of maternal process involved in parturition" EXACT [GOC:TermGenie]
synonym: "upregulation of maternal process involved in parturition" EXACT [GOC:TermGenie]
is_a: GO:0043902 ! positive regulation of multi-organism process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1904301 ! regulation of maternal process involved in parturition
is_a: GO:2000243 ! positive regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060137 ! maternal process involved in parturition
relationship: positively_regulates GO:0060137 ! maternal process involved in parturition
created_by: sl
creation_date: 2015-06-09T23:01:45Z

[Term]
id: GO:1904304
name: regulation of gastro-intestinal system smooth muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gastro-intestinal system smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:10821044]
is_a: GO:0006940 ! regulation of smooth muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0014831 ! gastro-intestinal system smooth muscle contraction
relationship: regulates GO:0014831 ! gastro-intestinal system smooth muscle contraction
created_by: sl
creation_date: 2015-06-09T23:18:42Z

[Term]
id: GO:1904305
name: negative regulation of gastro-intestinal system smooth muscle contraction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of gastro-intestinal system smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:10821044]
synonym: "down regulation of gastro-intestinal system smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "down-regulation of gastro-intestinal system smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "downregulation of gastro-intestinal system smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "inhibition of gastro-intestinal system smooth muscle contraction" NARROW [GOC:TermGenie]
is_a: GO:0045986 ! negative regulation of smooth muscle contraction
is_a: GO:1904304 ! regulation of gastro-intestinal system smooth muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0014831 ! gastro-intestinal system smooth muscle contraction
relationship: negatively_regulates GO:0014831 ! gastro-intestinal system smooth muscle contraction
created_by: sl
creation_date: 2015-06-09T23:18:48Z

[Term]
id: GO:1904306
name: positive regulation of gastro-intestinal system smooth muscle contraction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of gastro-intestinal system smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:10821044]
synonym: "activation of gastro-intestinal system smooth muscle contraction" NARROW [GOC:TermGenie]
synonym: "up regulation of gastro-intestinal system smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "up-regulation of gastro-intestinal system smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "upregulation of gastro-intestinal system smooth muscle contraction" EXACT [GOC:TermGenie]
is_a: GO:0045987 ! positive regulation of smooth muscle contraction
is_a: GO:1904304 ! regulation of gastro-intestinal system smooth muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0014831 ! gastro-intestinal system smooth muscle contraction
relationship: positively_regulates GO:0014831 ! gastro-intestinal system smooth muscle contraction
created_by: sl
creation_date: 2015-06-09T23:18:54Z

[Term]
id: GO:1904307
name: response to desipramine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desipramine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20549303]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
created_by: sl
creation_date: 2015-06-10T17:00:31Z

[Term]
id: GO:1904308
name: cellular response to desipramine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desipramine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20549303]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:1904307 ! response to desipramine
created_by: sl
creation_date: 2015-06-10T17:00:37Z

[Term]
id: GO:1904309
name: response to cordycepin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cordycepin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21597460]
synonym: "response to 3'-deoxyadenosine" EXACT [GOC:sl]
is_a: GO:0014074 ! response to purine-containing compound
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: sl
creation_date: 2015-06-10T17:10:29Z

[Term]
id: GO:1904310
name: cellular response to cordycepin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cordycepin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21597460]
synonym: "cellular response to 3'-deoxyadenosine" EXACT [GOC:sl]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1904309 ! response to cordycepin
created_by: sl
creation_date: 2015-06-10T17:10:35Z

[Term]
id: GO:1904311
name: response to gold(3+)
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gold(3+) stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16206274]
is_a: GO:0010035 ! response to inorganic substance
is_a: GO:1990268 ! response to gold nanoparticle
created_by: sl
creation_date: 2015-06-10T17:41:07Z

[Term]
id: GO:1904312
name: cellular response to gold(3+)
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gold(3+) stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16206274]
is_a: GO:0070887 ! cellular response to chemical stimulus
is_a: GO:1904311 ! response to gold(3+)
created_by: sl
creation_date: 2015-06-10T17:41:13Z

[Term]
id: GO:1904313
name: response to methamphetamine hydrochloride
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methamphetamine hydrochloride stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22174933]
synonym: "response to methamphetamine HCL" EXACT []
is_a: GO:1902074 ! response to salt
created_by: sl
creation_date: 2015-06-10T17:47:09Z

[Term]
id: GO:1904314
name: cellular response to methamphetamine hydrochloride
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methamphetamine hydrochloride stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22174933]
synonym: "cellular response to methamphetamine HCL" EXACT []
is_a: GO:1902075 ! cellular response to salt
is_a: GO:1904313 ! response to methamphetamine hydrochloride
created_by: sl
creation_date: 2015-06-10T17:47:15Z

[Term]
id: GO:1904315
name: transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
namespace: molecular_function
def: "Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]
subset: goslim_synapse
synonym: "ionotropic neurotransmitter receptor activity involved in regulation of post-synaptic membrane potential" NARROW [GOC:TermGenie]
synonym: "ionotropic neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential" NARROW [GOC:TermGenie]
synonym: "transmitter-gated ion channel activity involved in regulation of post-synaptic membrane potential" EXACT [GOC:TermGenie]
is_a: GO:0022824 ! transmitter-gated ion channel activity
is_a: GO:0099529 ! neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
intersection_of: GO:0022824 ! transmitter-gated ion channel activity
intersection_of: part_of GO:0060078 ! regulation of postsynaptic membrane potential
relationship: part_of GO:0060078 ! regulation of postsynaptic membrane potential
created_by: dos
creation_date: 2015-06-10T18:02:07Z

[Term]
id: GO:1904316
name: response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:9321918]
synonym: "response to PAF" EXACT []
synonym: "response to platelet-activating factor" EXACT []
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0033993 ! response to lipid
is_a: GO:0046683 ! response to organophosphorus
is_a: GO:0060359 ! response to ammonium ion
is_a: GO:0097305 ! response to alcohol
created_by: sl
creation_date: 2015-06-10T18:10:17Z

[Term]
id: GO:1904317
name: cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:9321918]
synonym: "response to PAF" EXACT []
synonym: "response to platelet-activating factor" EXACT []
is_a: GO:0071242 ! cellular response to ammonium ion
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:0097306 ! cellular response to alcohol
is_a: GO:1904316 ! response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine
created_by: sl
creation_date: 2015-06-10T18:10:23Z

[Term]
id: GO:1904318
name: regulation of smooth muscle contraction involved in micturition
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of smooth muscle contraction involved in micturition." [GO_REF:0000058, GOC:TermGenie, PMID:18562635]
synonym: "regulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie]
synonym: "regulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie]
is_a: GO:0006940 ! regulation of smooth muscle contraction
is_a: GO:0044062 ! regulation of excretion
is_a: GO:0098801 ! regulation of renal system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060083 ! smooth muscle contraction involved in micturition
relationship: regulates GO:0060083 ! smooth muscle contraction involved in micturition
created_by: sl
creation_date: 2015-06-10T18:46:11Z

[Term]
id: GO:1904319
name: negative regulation of smooth muscle contraction involved in micturition
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle contraction involved in micturition." [GO_REF:0000058, GOC:TermGenie, PMID:18562635]
synonym: "down regulation of smooth muscle contraction involved in micturition" EXACT [GOC:TermGenie]
synonym: "down regulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie]
synonym: "down regulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie]
synonym: "down-regulation of smooth muscle contraction involved in micturition" EXACT [GOC:TermGenie]
synonym: "down-regulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie]
synonym: "down-regulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie]
synonym: "downregulation of smooth muscle contraction involved in micturition" EXACT [GOC:TermGenie]
synonym: "downregulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie]
synonym: "downregulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie]
synonym: "inhibition of smooth muscle contraction involved in micturition" NARROW [GOC:TermGenie]
synonym: "inhibition of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie]
synonym: "inhibition of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie]
synonym: "negative regulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie]
synonym: "negative regulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie]
is_a: GO:0045986 ! negative regulation of smooth muscle contraction
is_a: GO:1904318 ! regulation of smooth muscle contraction involved in micturition
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060083 ! smooth muscle contraction involved in micturition
relationship: negatively_regulates GO:0060083 ! smooth muscle contraction involved in micturition
created_by: sl
creation_date: 2015-06-10T18:46:17Z

[Term]
id: GO:1904320
name: positive regulation of smooth muscle contraction involved in micturition
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of smooth muscle contraction involved in micturition." [GO_REF:0000058, GOC:TermGenie, PMID:18562635]
synonym: "activation of smooth muscle contraction involved in micturition" NARROW [GOC:TermGenie]
synonym: "activation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie]
synonym: "activation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie]
synonym: "positive regulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie]
synonym: "positive regulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie]
synonym: "up regulation of smooth muscle contraction involved in micturition" EXACT [GOC:TermGenie]
synonym: "up regulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie]
synonym: "up regulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie]
synonym: "up-regulation of smooth muscle contraction involved in micturition" EXACT [GOC:TermGenie]
synonym: "up-regulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie]
synonym: "up-regulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie]
synonym: "upregulation of smooth muscle contraction involved in micturition" EXACT [GOC:TermGenie]
synonym: "upregulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie]
synonym: "upregulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie]
is_a: GO:0045987 ! positive regulation of smooth muscle contraction
is_a: GO:1904318 ! regulation of smooth muscle contraction involved in micturition
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060083 ! smooth muscle contraction involved in micturition
relationship: positively_regulates GO:0060083 ! smooth muscle contraction involved in micturition
created_by: sl
creation_date: 2015-06-10T18:46:23Z

[Term]
id: GO:1904321
name: response to forskolin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a forskolin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:15937517]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033993 ! response to lipid
is_a: GO:1901654 ! response to ketone
created_by: sl
creation_date: 2015-06-10T19:01:27Z

[Term]
id: GO:1904322
name: cellular response to forskolin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a forskolin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:15937517]
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901655 ! cellular response to ketone
is_a: GO:1904321 ! response to forskolin
created_by: sl
creation_date: 2015-06-10T19:01:33Z

[Term]
id: GO:1904323
name: regulation of inhibitory G-protein coupled receptor phosphorylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of inhibitory G-protein coupled receptor phosphorylation." [GO_REF:0000058, GOC:TermGenie, PMID:15937517]
is_a: GO:0001932 ! regulation of protein phosphorylation
is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002030 ! inhibitory G-protein coupled receptor phosphorylation
relationship: regulates GO:0002030 ! inhibitory G-protein coupled receptor phosphorylation
created_by: sl
creation_date: 2015-06-10T19:46:37Z

[Term]
id: GO:1904324
name: negative regulation of inhibitory G-protein coupled receptor phosphorylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of inhibitory G-protein coupled receptor phosphorylation." [GO_REF:0000058, GOC:TermGenie, PMID:15937517]
synonym: "down regulation of inhibitory G-protein coupled receptor phosphorylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of inhibitory G-protein coupled receptor phosphorylation" EXACT [GOC:TermGenie]
synonym: "downregulation of inhibitory G-protein coupled receptor phosphorylation" EXACT [GOC:TermGenie]
synonym: "inhibition of inhibitory G-protein coupled receptor phosphorylation" NARROW [GOC:TermGenie]
is_a: GO:0001933 ! negative regulation of protein phosphorylation
is_a: GO:0045745 ! positive regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:1904323 ! regulation of inhibitory G-protein coupled receptor phosphorylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002030 ! inhibitory G-protein coupled receptor phosphorylation
relationship: negatively_regulates GO:0002030 ! inhibitory G-protein coupled receptor phosphorylation
created_by: sl
creation_date: 2015-06-10T19:46:43Z

[Term]
id: GO:1904325
name: positive regulation of inhibitory G-protein coupled receptor phosphorylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of inhibitory G-protein coupled receptor phosphorylation." [GO_REF:0000058, GOC:TermGenie, PMID:15937517]
synonym: "activation of inhibitory G-protein coupled receptor phosphorylation" NARROW [GOC:TermGenie]
synonym: "up regulation of inhibitory G-protein coupled receptor phosphorylation" EXACT [GOC:TermGenie]
synonym: "up-regulation of inhibitory G-protein coupled receptor phosphorylation" EXACT [GOC:TermGenie]
synonym: "upregulation of inhibitory G-protein coupled receptor phosphorylation" EXACT [GOC:TermGenie]
is_a: GO:0001934 ! positive regulation of protein phosphorylation
is_a: GO:1904323 ! regulation of inhibitory G-protein coupled receptor phosphorylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002030 ! inhibitory G-protein coupled receptor phosphorylation
relationship: positively_regulates GO:0002030 ! inhibitory G-protein coupled receptor phosphorylation
created_by: sl
creation_date: 2015-06-10T19:46:50Z

[Term]
id: GO:1904326
name: negative regulation of circadian sleep/wake cycle, wakefulness
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of circadian sleep/wake cycle, wakefulness." [GO_REF:0000058, GOC:TermGenie, PMID:10923657]
synonym: "down regulation of circadian sleep/wake cycle, wakefulness" EXACT [GOC:TermGenie]
synonym: "down-regulation of circadian sleep/wake cycle, wakefulness" EXACT [GOC:TermGenie]
synonym: "downregulation of circadian sleep/wake cycle, wakefulness" EXACT [GOC:TermGenie]
synonym: "inhibition of circadian sleep/wake cycle, wakefulness" NARROW [GOC:TermGenie]
is_a: GO:0010840 ! regulation of circadian sleep/wake cycle, wakefulness
is_a: GO:0042754 ! negative regulation of circadian rhythm
is_a: GO:0048521 ! negative regulation of behavior
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042746 ! circadian sleep/wake cycle, wakefulness
relationship: negatively_regulates GO:0042746 ! circadian sleep/wake cycle, wakefulness
created_by: sl
creation_date: 2015-06-10T20:18:45Z

[Term]
id: GO:1904327
name: protein localization to cytosolic proteasome complex
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a cytosolic proteasome complex." [GO_REF:0000087, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:17000876]
synonym: "protein localisation in cytosolic proteasome complex" EXACT [GOC:TermGenie]
synonym: "protein localisation to cytosolic proteasome complex" EXACT [GOC:TermGenie]
synonym: "protein localization in cytosolic proteasome complex" EXACT [GOC:TermGenie]
is_a: GO:0008104 ! protein localization
created_by: bf
creation_date: 2015-06-11T09:29:53Z

[Term]
id: GO:1904328
name: regulation of myofibroblast contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of myofibroblast contraction." [GO_REF:0000058, GOC:TermGenie, PMID:19239477]
synonym: "regulation of MF contraction" EXACT [GOC:TermGenie]
synonym: "regulation of MFB contraction" EXACT [GOC:TermGenie]
is_a: GO:1903115 ! regulation of actin filament-based movement
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990764 ! myofibroblast contraction
relationship: regulates GO:1990764 ! myofibroblast contraction
created_by: sl
creation_date: 2015-06-11T15:30:29Z

[Term]
id: GO:1904329
name: negative regulation of myofibroblast contraction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of myofibroblast contraction." [GO_REF:0000058, GOC:TermGenie, PMID:19239477]
synonym: "down regulation of MF contraction" EXACT [GOC:TermGenie]
synonym: "down regulation of MFB contraction" EXACT [GOC:TermGenie]
synonym: "down regulation of myofibroblast contraction" EXACT [GOC:TermGenie]
synonym: "down-regulation of MF contraction" EXACT [GOC:TermGenie]
synonym: "down-regulation of MFB contraction" EXACT [GOC:TermGenie]
synonym: "down-regulation of myofibroblast contraction" EXACT [GOC:TermGenie]
synonym: "downregulation of MF contraction" EXACT [GOC:TermGenie]
synonym: "downregulation of MFB contraction" EXACT [GOC:TermGenie]
synonym: "downregulation of myofibroblast contraction" EXACT [GOC:TermGenie]
synonym: "inhibition of MF contraction" NARROW [GOC:TermGenie]
synonym: "inhibition of MFB contraction" NARROW [GOC:TermGenie]
synonym: "inhibition of myofibroblast contraction" NARROW [GOC:TermGenie]
synonym: "negative regulation of MF contraction" EXACT [GOC:TermGenie]
synonym: "negative regulation of MFB contraction" EXACT [GOC:TermGenie]
is_a: GO:0051271 ! negative regulation of cellular component movement
is_a: GO:1904328 ! regulation of myofibroblast contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990764 ! myofibroblast contraction
relationship: negatively_regulates GO:1990764 ! myofibroblast contraction
created_by: sl
creation_date: 2015-06-11T15:30:35Z

[Term]
id: GO:1904330
name: positive regulation of myofibroblast contraction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of myofibroblast contraction." [GO_REF:0000058, GOC:TermGenie, PMID:19239477]
synonym: "activation of MF contraction" NARROW [GOC:TermGenie]
synonym: "activation of MFB contraction" NARROW [GOC:TermGenie]
synonym: "activation of myofibroblast contraction" NARROW [GOC:TermGenie]
synonym: "positive regulation of MF contraction" EXACT [GOC:TermGenie]
synonym: "positive regulation of MFB contraction" EXACT [GOC:TermGenie]
synonym: "up regulation of MF contraction" EXACT [GOC:TermGenie]
synonym: "up regulation of MFB contraction" EXACT [GOC:TermGenie]
synonym: "up regulation of myofibroblast contraction" EXACT [GOC:TermGenie]
synonym: "up-regulation of MF contraction" EXACT [GOC:TermGenie]
synonym: "up-regulation of MFB contraction" EXACT [GOC:TermGenie]
synonym: "up-regulation of myofibroblast contraction" EXACT [GOC:TermGenie]
synonym: "upregulation of MF contraction" EXACT [GOC:TermGenie]
synonym: "upregulation of MFB contraction" EXACT [GOC:TermGenie]
synonym: "upregulation of myofibroblast contraction" EXACT [GOC:TermGenie]
is_a: GO:1903116 ! positive regulation of actin filament-based movement
is_a: GO:1904328 ! regulation of myofibroblast contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990764 ! myofibroblast contraction
relationship: positively_regulates GO:1990764 ! myofibroblast contraction
created_by: sl
creation_date: 2015-06-11T15:30:41Z

[Term]
id: GO:1904331
name: regulation of error-prone translesion synthesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of error-prone translesion synthesis." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:22761594]
synonym: "regulation of error-prone postreplication DNA repair" RELATED [GOC:TermGenie]
synonym: "regulation of mutagenic postreplication DNA repair" RELATED [GOC:TermGenie]
synonym: "regulation of mutagenic PRR" EXACT [GOC:TermGenie]
is_a: GO:0006282 ! regulation of DNA repair
is_a: GO:2000278 ! regulation of DNA biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042276 ! error-prone translesion synthesis
relationship: regulates GO:0042276 ! error-prone translesion synthesis
created_by: kmv
creation_date: 2015-06-11T16:24:47Z

[Term]
id: GO:1904332
name: negative regulation of error-prone translesion synthesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of error-prone translesion synthesis." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:22761594]
synonym: "down regulation of error-prone postreplication DNA repair" RELATED [GOC:TermGenie]
synonym: "down regulation of error-prone translesion synthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of mutagenic postreplication DNA repair" RELATED [GOC:TermGenie]
synonym: "down regulation of mutagenic PRR" EXACT [GOC:TermGenie]
synonym: "down-regulation of error-prone postreplication DNA repair" RELATED [GOC:TermGenie]
synonym: "down-regulation of error-prone translesion synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of mutagenic postreplication DNA repair" RELATED [GOC:TermGenie]
synonym: "down-regulation of mutagenic PRR" EXACT [GOC:TermGenie]
synonym: "downregulation of error-prone postreplication DNA repair" RELATED [GOC:TermGenie]
synonym: "downregulation of error-prone translesion synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of mutagenic postreplication DNA repair" RELATED [GOC:TermGenie]
synonym: "downregulation of mutagenic PRR" EXACT [GOC:TermGenie]
synonym: "inhibition of error-prone postreplication DNA repair" RELATED [GOC:TermGenie]
synonym: "inhibition of error-prone translesion synthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of mutagenic postreplication DNA repair" RELATED [GOC:TermGenie]
synonym: "inhibition of mutagenic PRR" NARROW [GOC:TermGenie]
synonym: "negative regulation of error-prone postreplication DNA repair" RELATED [GOC:TermGenie]
synonym: "negative regulation of mutagenic postreplication DNA repair" RELATED [GOC:TermGenie]
synonym: "negative regulation of mutagenic PRR" EXACT [GOC:TermGenie]
is_a: GO:0045738 ! negative regulation of DNA repair
is_a: GO:1904331 ! regulation of error-prone translesion synthesis
is_a: GO:2000279 ! negative regulation of DNA biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042276 ! error-prone translesion synthesis
relationship: negatively_regulates GO:0042276 ! error-prone translesion synthesis
created_by: kmv
creation_date: 2015-06-11T16:24:53Z

[Term]
id: GO:1904333
name: positive regulation of error-prone translesion synthesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of error-prone translesion synthesis." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:22761594]
synonym: "activation of error-prone postreplication DNA repair" RELATED [GOC:TermGenie]
synonym: "activation of error-prone translesion synthesis" NARROW [GOC:TermGenie]
synonym: "activation of mutagenic postreplication DNA repair" RELATED [GOC:TermGenie]
synonym: "activation of mutagenic PRR" NARROW [GOC:TermGenie]
synonym: "positive regulation of error-prone postreplication DNA repair" RELATED [GOC:TermGenie]
synonym: "positive regulation of mutagenic postreplication DNA repair" RELATED [GOC:TermGenie]
synonym: "positive regulation of mutagenic PRR" EXACT [GOC:TermGenie]
synonym: "up regulation of error-prone postreplication DNA repair" RELATED [GOC:TermGenie]
synonym: "up regulation of error-prone translesion synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of mutagenic postreplication DNA repair" RELATED [GOC:TermGenie]
synonym: "up regulation of mutagenic PRR" EXACT [GOC:TermGenie]
synonym: "up-regulation of error-prone postreplication DNA repair" RELATED [GOC:TermGenie]
synonym: "up-regulation of error-prone translesion synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of mutagenic postreplication DNA repair" RELATED [GOC:TermGenie]
synonym: "up-regulation of mutagenic PRR" EXACT [GOC:TermGenie]
synonym: "upregulation of error-prone postreplication DNA repair" RELATED [GOC:TermGenie]
synonym: "upregulation of error-prone translesion synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of mutagenic postreplication DNA repair" RELATED [GOC:TermGenie]
synonym: "upregulation of mutagenic PRR" EXACT [GOC:TermGenie]
is_a: GO:0045739 ! positive regulation of DNA repair
is_a: GO:1904331 ! regulation of error-prone translesion synthesis
is_a: GO:2000573 ! positive regulation of DNA biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042276 ! error-prone translesion synthesis
relationship: positively_regulates GO:0042276 ! error-prone translesion synthesis
created_by: kmv
creation_date: 2015-06-11T16:25:10Z

[Term]
id: GO:1904334
name: heme import across plasma membrane
namespace: biological_process
def: "The directed movement of heme from outside of a cell into the cytoplasmic compartment." [GO_REF:0000075, GOC:TermGenie, PMID:25733668]
is_a: GO:0035351 ! heme transmembrane transport
is_a: GO:0098739 ! import across plasma membrane
created_by: al
creation_date: 2015-06-11T16:56:21Z

[Term]
id: GO:1904335
name: regulation of ductus arteriosus closure
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ductus arteriosus closure." [GO_REF:0000058, GOC:TermGenie, PMID:16303610]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:1901342 ! regulation of vasculature development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097070 ! ductus arteriosus closure
relationship: regulates GO:0097070 ! ductus arteriosus closure
created_by: sl
creation_date: 2015-06-11T17:45:15Z

[Term]
id: GO:1904336
name: negative regulation of ductus arteriosus closure
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ductus arteriosus closure." [GO_REF:0000058, GOC:TermGenie, PMID:16303610]
synonym: "down regulation of ductus arteriosus closure" EXACT [GOC:TermGenie]
synonym: "down-regulation of ductus arteriosus closure" EXACT [GOC:TermGenie]
synonym: "downregulation of ductus arteriosus closure" EXACT [GOC:TermGenie]
synonym: "inhibition of ductus arteriosus closure" NARROW [GOC:TermGenie]
is_a: GO:1904335 ! regulation of ductus arteriosus closure
is_a: GO:2000181 ! negative regulation of blood vessel morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097070 ! ductus arteriosus closure
relationship: negatively_regulates GO:0097070 ! ductus arteriosus closure
created_by: sl
creation_date: 2015-06-11T17:45:21Z

[Term]
id: GO:1904337
name: positive regulation of ductus arteriosus closure
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ductus arteriosus closure." [GO_REF:0000058, GOC:TermGenie, PMID:16303610]
synonym: "activation of ductus arteriosus closure" NARROW [GOC:TermGenie]
synonym: "up regulation of ductus arteriosus closure" EXACT [GOC:TermGenie]
synonym: "up-regulation of ductus arteriosus closure" EXACT [GOC:TermGenie]
synonym: "upregulation of ductus arteriosus closure" EXACT [GOC:TermGenie]
is_a: GO:1904018 ! positive regulation of vasculature development
is_a: GO:1904335 ! regulation of ductus arteriosus closure
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097070 ! ductus arteriosus closure
relationship: positively_regulates GO:0097070 ! ductus arteriosus closure
created_by: sl
creation_date: 2015-06-11T17:45:27Z

[Term]
id: GO:1904338
name: regulation of dopaminergic neuron differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dopaminergic neuron differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:15522889]
is_a: GO:0045664 ! regulation of neuron differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071542 ! dopaminergic neuron differentiation
relationship: regulates GO:0071542 ! dopaminergic neuron differentiation
created_by: sl
creation_date: 2015-06-11T18:06:19Z

[Term]
id: GO:1904339
name: negative regulation of dopaminergic neuron differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of dopaminergic neuron differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:15522889]
synonym: "down regulation of dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of dopaminergic neuron differentiation" NARROW [GOC:TermGenie]
is_a: GO:0045665 ! negative regulation of neuron differentiation
is_a: GO:1904338 ! regulation of dopaminergic neuron differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071542 ! dopaminergic neuron differentiation
relationship: negatively_regulates GO:0071542 ! dopaminergic neuron differentiation
created_by: sl
creation_date: 2015-06-11T18:06:25Z

[Term]
id: GO:1904340
name: positive regulation of dopaminergic neuron differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of dopaminergic neuron differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:15522889]
synonym: "activation of dopaminergic neuron differentiation" NARROW [GOC:TermGenie]
synonym: "up regulation of dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045666 ! positive regulation of neuron differentiation
is_a: GO:1904338 ! regulation of dopaminergic neuron differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071542 ! dopaminergic neuron differentiation
relationship: positively_regulates GO:0071542 ! dopaminergic neuron differentiation
created_by: sl
creation_date: 2015-06-11T18:06:32Z

[Term]
id: GO:1904341
name: regulation of colon smooth muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of colon smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:24170253]
is_a: GO:1904304 ! regulation of gastro-intestinal system smooth muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990765 ! colon smooth muscle contraction
relationship: regulates GO:1990765 ! colon smooth muscle contraction
created_by: sl
creation_date: 2015-06-11T21:16:58Z

[Term]
id: GO:1904342
name: negative regulation of colon smooth muscle contraction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of colon smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:24170253]
synonym: "down regulation of colon smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "down-regulation of colon smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "downregulation of colon smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "inhibition of colon smooth muscle contraction" NARROW [GOC:TermGenie]
is_a: GO:1904305 ! negative regulation of gastro-intestinal system smooth muscle contraction
is_a: GO:1904341 ! regulation of colon smooth muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990765 ! colon smooth muscle contraction
relationship: negatively_regulates GO:1990765 ! colon smooth muscle contraction
created_by: sl
creation_date: 2015-06-11T21:17:05Z

[Term]
id: GO:1904343
name: positive regulation of colon smooth muscle contraction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of colon smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:24170253]
synonym: "activation of colon smooth muscle contraction" NARROW [GOC:TermGenie]
synonym: "up regulation of colon smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "up-regulation of colon smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "upregulation of colon smooth muscle contraction" EXACT [GOC:TermGenie]
is_a: GO:1904306 ! positive regulation of gastro-intestinal system smooth muscle contraction
is_a: GO:1904341 ! regulation of colon smooth muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990765 ! colon smooth muscle contraction
relationship: positively_regulates GO:1990765 ! colon smooth muscle contraction
created_by: sl
creation_date: 2015-06-11T21:17:11Z

[Term]
id: GO:1904344
name: regulation of gastric mucosal blood circulation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gastric mucosal blood circulation." [GO_REF:0000058, GOC:TermGenie, PMID:10807413]
synonym: "regulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie]
is_a: GO:1903522 ! regulation of blood circulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990768 ! gastric mucosal blood circulation
relationship: regulates GO:1990768 ! gastric mucosal blood circulation
created_by: sl
creation_date: 2015-06-11T21:20:31Z

[Term]
id: GO:1904345
name: negative regulation of gastric mucosal blood circulation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of gastric mucosal blood circulation." [GO_REF:0000058, GOC:TermGenie, PMID:10807413]
synonym: "down regulation of gastric mucosal blood circulation" EXACT [GOC:TermGenie]
synonym: "down regulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie]
synonym: "down-regulation of gastric mucosal blood circulation" EXACT [GOC:TermGenie]
synonym: "down-regulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie]
synonym: "downregulation of gastric mucosal blood circulation" EXACT [GOC:TermGenie]
synonym: "downregulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie]
synonym: "inhibition of gastric mucosal blood circulation" NARROW [GOC:TermGenie]
synonym: "inhibition of stomach mucosal blood circulation" NARROW [GOC:TermGenie]
synonym: "negative regulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie]
is_a: GO:1903523 ! negative regulation of blood circulation
is_a: GO:1904344 ! regulation of gastric mucosal blood circulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990768 ! gastric mucosal blood circulation
relationship: negatively_regulates GO:1990768 ! gastric mucosal blood circulation
created_by: sl
creation_date: 2015-06-11T21:20:44Z

[Term]
id: GO:1904346
name: positive regulation of gastric mucosal blood circulation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of gastric mucosal blood circulation." [GO_REF:0000058, GOC:TermGenie, PMID:10807413]
synonym: "activation of gastric mucosal blood circulation" NARROW [GOC:TermGenie]
synonym: "activation of stomach mucosal blood circulation" NARROW [GOC:TermGenie]
synonym: "positive regulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie]
synonym: "up regulation of gastric mucosal blood circulation" EXACT [GOC:TermGenie]
synonym: "up regulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie]
synonym: "up-regulation of gastric mucosal blood circulation" EXACT [GOC:TermGenie]
synonym: "up-regulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie]
synonym: "upregulation of gastric mucosal blood circulation" EXACT [GOC:TermGenie]
synonym: "upregulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie]
is_a: GO:1903524 ! positive regulation of blood circulation
is_a: GO:1904344 ! regulation of gastric mucosal blood circulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990768 ! gastric mucosal blood circulation
relationship: positively_regulates GO:1990768 ! gastric mucosal blood circulation
created_by: sl
creation_date: 2015-06-11T21:20:50Z

[Term]
id: GO:1904347
name: regulation of small intestine smooth muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of small intestine smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:11991626]
is_a: GO:1904304 ! regulation of gastro-intestinal system smooth muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990770 ! small intestine smooth muscle contraction
relationship: regulates GO:1990770 ! small intestine smooth muscle contraction
created_by: sl
creation_date: 2015-06-11T21:37:34Z

[Term]
id: GO:1904348
name: negative regulation of small intestine smooth muscle contraction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of small intestine smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:11991626]
synonym: "down regulation of small intestine smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "down-regulation of small intestine smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "downregulation of small intestine smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "inhibition of small intestine smooth muscle contraction" NARROW [GOC:TermGenie]
is_a: GO:1904305 ! negative regulation of gastro-intestinal system smooth muscle contraction
is_a: GO:1904347 ! regulation of small intestine smooth muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990770 ! small intestine smooth muscle contraction
relationship: negatively_regulates GO:1990770 ! small intestine smooth muscle contraction
created_by: sl
creation_date: 2015-06-11T21:37:40Z

[Term]
id: GO:1904349
name: positive regulation of small intestine smooth muscle contraction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of small intestine smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:11991626]
synonym: "activation of small intestine smooth muscle contraction" NARROW [GOC:TermGenie]
synonym: "up regulation of small intestine smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "up-regulation of small intestine smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "upregulation of small intestine smooth muscle contraction" EXACT [GOC:TermGenie]
is_a: GO:1904306 ! positive regulation of gastro-intestinal system smooth muscle contraction
is_a: GO:1904347 ! regulation of small intestine smooth muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990770 ! small intestine smooth muscle contraction
relationship: positively_regulates GO:1990770 ! small intestine smooth muscle contraction
created_by: sl
creation_date: 2015-06-11T21:37:46Z

[Term]
id: GO:1904350
name: regulation of protein catabolic process in the vacuole
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein catabolic process in the vacuole." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:25635054]
synonym: "regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie]
synonym: "regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie]
synonym: "regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie]
synonym: "regulation of vacuolar protein degradation" RELATED [GOC:TermGenie]
is_a: GO:1903362 ! regulation of cellular protein catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007039 ! protein catabolic process in the vacuole
relationship: regulates GO:0007039 ! protein catabolic process in the vacuole
created_by: rl
creation_date: 2015-06-12T09:10:36Z

[Term]
id: GO:1904351
name: negative regulation of protein catabolic process in the vacuole
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process in the vacuole." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:25635054]
synonym: "down regulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie]
synonym: "down regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie]
synonym: "down regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie]
synonym: "down regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie]
synonym: "down regulation of vacuolar protein degradation" RELATED [GOC:TermGenie]
synonym: "down-regulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie]
synonym: "down-regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie]
synonym: "down-regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie]
synonym: "down-regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie]
synonym: "down-regulation of vacuolar protein degradation" RELATED [GOC:TermGenie]
synonym: "downregulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie]
synonym: "downregulation of vacuolar protein breakdown" RELATED [GOC:TermGenie]
synonym: "downregulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie]
synonym: "downregulation of vacuolar protein catabolism" RELATED [GOC:TermGenie]
synonym: "downregulation of vacuolar protein degradation" RELATED [GOC:TermGenie]
synonym: "inhibition of protein catabolic process in the vacuole" NARROW [GOC:TermGenie]
synonym: "inhibition of vacuolar protein breakdown" RELATED [GOC:TermGenie]
synonym: "inhibition of vacuolar protein catabolic process" RELATED [GOC:TermGenie]
synonym: "inhibition of vacuolar protein catabolism" RELATED [GOC:TermGenie]
synonym: "inhibition of vacuolar protein degradation" RELATED [GOC:TermGenie]
synonym: "negative regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie]
synonym: "negative regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie]
synonym: "negative regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie]
synonym: "negative regulation of vacuolar protein degradation" RELATED [GOC:TermGenie]
is_a: GO:1903363 ! negative regulation of cellular protein catabolic process
is_a: GO:1904350 ! regulation of protein catabolic process in the vacuole
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007039 ! protein catabolic process in the vacuole
relationship: negatively_regulates GO:0007039 ! protein catabolic process in the vacuole
created_by: rl
creation_date: 2015-06-12T09:10:42Z

[Term]
id: GO:1904352
name: positive regulation of protein catabolic process in the vacuole
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein catabolic process in the vacuole." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:25635054]
synonym: "activation of protein catabolic process in the vacuole" NARROW [GOC:TermGenie]
synonym: "activation of vacuolar protein breakdown" RELATED [GOC:TermGenie]
synonym: "activation of vacuolar protein catabolic process" RELATED [GOC:TermGenie]
synonym: "activation of vacuolar protein catabolism" RELATED [GOC:TermGenie]
synonym: "activation of vacuolar protein degradation" RELATED [GOC:TermGenie]
synonym: "positive regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie]
synonym: "positive regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie]
synonym: "positive regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie]
synonym: "positive regulation of vacuolar protein degradation" RELATED [GOC:TermGenie]
synonym: "up regulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie]
synonym: "up regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie]
synonym: "up regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie]
synonym: "up regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie]
synonym: "up regulation of vacuolar protein degradation" RELATED [GOC:TermGenie]
synonym: "up-regulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie]
synonym: "up-regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie]
synonym: "up-regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie]
synonym: "up-regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie]
synonym: "up-regulation of vacuolar protein degradation" RELATED [GOC:TermGenie]
synonym: "upregulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie]
synonym: "upregulation of vacuolar protein breakdown" RELATED [GOC:TermGenie]
synonym: "upregulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie]
synonym: "upregulation of vacuolar protein catabolism" RELATED [GOC:TermGenie]
synonym: "upregulation of vacuolar protein degradation" RELATED [GOC:TermGenie]
is_a: GO:1903364 ! positive regulation of cellular protein catabolic process
is_a: GO:1904350 ! regulation of protein catabolic process in the vacuole
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007039 ! protein catabolic process in the vacuole
relationship: positively_regulates GO:0007039 ! protein catabolic process in the vacuole
created_by: rl
creation_date: 2015-06-12T09:10:49Z

[Term]
id: GO:1904353
name: regulation of telomere capping
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of telomere capping." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892]
synonym: "regulation of telomere end protection" EXACT [GOC:TermGenie]
is_a: GO:0032204 ! regulation of telomere maintenance
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016233 ! telomere capping
relationship: regulates GO:0016233 ! telomere capping
created_by: nc
creation_date: 2015-06-12T16:51:08Z

[Term]
id: GO:1904354
name: negative regulation of telomere capping
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of telomere capping." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892]
synonym: "down regulation of telomere capping" EXACT [GOC:TermGenie]
synonym: "down regulation of telomere end protection" EXACT [GOC:TermGenie]
synonym: "down-regulation of telomere capping" EXACT [GOC:TermGenie]
synonym: "down-regulation of telomere end protection" EXACT [GOC:TermGenie]
synonym: "downregulation of telomere capping" EXACT [GOC:TermGenie]
synonym: "downregulation of telomere end protection" EXACT [GOC:TermGenie]
synonym: "inhibition of telomere capping" NARROW [GOC:TermGenie]
synonym: "inhibition of telomere end protection" NARROW [GOC:TermGenie]
synonym: "negative regulation of telomere end protection" EXACT [GOC:TermGenie]
is_a: GO:0032205 ! negative regulation of telomere maintenance
is_a: GO:1904353 ! regulation of telomere capping
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016233 ! telomere capping
relationship: negatively_regulates GO:0016233 ! telomere capping
created_by: nc
creation_date: 2015-06-12T16:51:14Z

[Term]
id: GO:1904355
name: positive regulation of telomere capping
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of telomere capping." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892]
synonym: "activation of telomere capping" NARROW [GOC:TermGenie]
synonym: "activation of telomere end protection" NARROW [GOC:TermGenie]
synonym: "positive regulation of telomere end protection" EXACT [GOC:TermGenie]
synonym: "up regulation of telomere capping" EXACT [GOC:TermGenie]
synonym: "up regulation of telomere end protection" EXACT [GOC:TermGenie]
synonym: "up-regulation of telomere capping" EXACT [GOC:TermGenie]
synonym: "up-regulation of telomere end protection" EXACT [GOC:TermGenie]
synonym: "upregulation of telomere capping" EXACT [GOC:TermGenie]
synonym: "upregulation of telomere end protection" EXACT [GOC:TermGenie]
is_a: GO:0032206 ! positive regulation of telomere maintenance
is_a: GO:1904353 ! regulation of telomere capping
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016233 ! telomere capping
relationship: positively_regulates GO:0016233 ! telomere capping
created_by: nc
creation_date: 2015-06-12T16:51:20Z

[Term]
id: GO:1904356
name: regulation of telomere maintenance via telomere lengthening
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of telomere maintenance via telomere lengthening." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:23959892]
is_a: GO:0032204 ! regulation of telomere maintenance
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010833 ! telomere maintenance via telomere lengthening
relationship: regulates GO:0010833 ! telomere maintenance via telomere lengthening
created_by: nc
creation_date: 2015-06-12T16:53:16Z

[Term]
id: GO:1904357
name: negative regulation of telomere maintenance via telomere lengthening
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of telomere maintenance via telomere lengthening." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:23959892]
synonym: "down regulation of telomere maintenance via telomere lengthening" EXACT [GOC:TermGenie]
synonym: "down-regulation of telomere maintenance via telomere lengthening" EXACT [GOC:TermGenie]
synonym: "downregulation of telomere maintenance via telomere lengthening" EXACT [GOC:TermGenie]
synonym: "inhibition of telomere maintenance via telomere lengthening" NARROW [GOC:TermGenie]
is_a: GO:0032205 ! negative regulation of telomere maintenance
is_a: GO:1904356 ! regulation of telomere maintenance via telomere lengthening
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010833 ! telomere maintenance via telomere lengthening
relationship: negatively_regulates GO:0010833 ! telomere maintenance via telomere lengthening
created_by: nc
creation_date: 2015-06-12T16:53:22Z

[Term]
id: GO:1904358
name: positive regulation of telomere maintenance via telomere lengthening
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of telomere maintenance via telomere lengthening." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:23959892]
synonym: "activation of telomere maintenance via telomere lengthening" NARROW [GOC:TermGenie]
synonym: "up regulation of telomere maintenance via telomere lengthening" EXACT [GOC:TermGenie]
synonym: "up-regulation of telomere maintenance via telomere lengthening" EXACT [GOC:TermGenie]
synonym: "upregulation of telomere maintenance via telomere lengthening" EXACT [GOC:TermGenie]
is_a: GO:0032206 ! positive regulation of telomere maintenance
is_a: GO:1904356 ! regulation of telomere maintenance via telomere lengthening
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010833 ! telomere maintenance via telomere lengthening
relationship: positively_regulates GO:0010833 ! telomere maintenance via telomere lengthening
created_by: nc
creation_date: 2015-06-12T16:53:28Z

[Term]
id: GO:1904359
name: regulation of spore germination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of spore germination." [GO_REF:0000058, GOC:TermGenie, PMID:14718564, PMID:8798577]
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009847 ! spore germination
relationship: regulates GO:0009847 ! spore germination
created_by: pf
creation_date: 2015-06-12T19:46:06Z

[Term]
id: GO:1904360
name: negative regulation of spore germination
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of spore germination." [GO_REF:0000058, GOC:TermGenie, PMID:14718564, PMID:8798577]
synonym: "down regulation of spore germination" EXACT [GOC:TermGenie]
synonym: "down-regulation of spore germination" EXACT [GOC:TermGenie]
synonym: "downregulation of spore germination" EXACT [GOC:TermGenie]
synonym: "inhibition of spore germination" NARROW [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:1904359 ! regulation of spore germination
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009847 ! spore germination
relationship: negatively_regulates GO:0009847 ! spore germination
created_by: pf
creation_date: 2015-06-12T19:46:12Z

[Term]
id: GO:1904361
name: positive regulation of spore germination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of spore germination." [GO_REF:0000058, GOC:TermGenie, PMID:14718564, PMID:8798577]
synonym: "activation of spore germination" NARROW [GOC:TermGenie]
synonym: "up regulation of spore germination" EXACT [GOC:TermGenie]
synonym: "up-regulation of spore germination" EXACT [GOC:TermGenie]
synonym: "upregulation of spore germination" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:1904359 ! regulation of spore germination
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009847 ! spore germination
relationship: positively_regulates GO:0009847 ! spore germination
created_by: pf
creation_date: 2015-06-12T19:46:18Z

[Term]
id: GO:1904362
name: regulation of calcitonin secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of calcitonin secretion." [GO_REF:0000058, GOC:TermGenie, PMID:11278900]
is_a: GO:0090276 ! regulation of peptide hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0036161 ! calcitonin secretion
relationship: regulates GO:0036161 ! calcitonin secretion
created_by: sl
creation_date: 2015-06-15T17:54:52Z

[Term]
id: GO:1904363
name: negative regulation of calcitonin secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcitonin secretion." [GO_REF:0000058, GOC:TermGenie, PMID:11278900]
synonym: "down regulation of calcitonin secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of calcitonin secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of calcitonin secretion" EXACT [GOC:TermGenie]
synonym: "inhibition of calcitonin secretion" NARROW [GOC:TermGenie]
is_a: GO:0090278 ! negative regulation of peptide hormone secretion
is_a: GO:1904362 ! regulation of calcitonin secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0036161 ! calcitonin secretion
relationship: negatively_regulates GO:0036161 ! calcitonin secretion
created_by: sl
creation_date: 2015-06-15T17:54:58Z

[Term]
id: GO:1904364
name: positive regulation of calcitonin secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of calcitonin secretion." [GO_REF:0000058, GOC:TermGenie, PMID:11278900]
synonym: "activation of calcitonin secretion" NARROW [GOC:TermGenie]
synonym: "up regulation of calcitonin secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of calcitonin secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of calcitonin secretion" EXACT [GOC:TermGenie]
is_a: GO:0090277 ! positive regulation of peptide hormone secretion
is_a: GO:1904362 ! regulation of calcitonin secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0036161 ! calcitonin secretion
relationship: positively_regulates GO:0036161 ! calcitonin secretion
created_by: sl
creation_date: 2015-06-15T17:55:05Z

[Term]
id: GO:1904365
name: regulation of chemokinesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chemokinesis." [GO_REF:0000058, GOC:TermGenie, PMID:8679543]
is_a: GO:0032101 ! regulation of response to external stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042466 ! chemokinesis
relationship: regulates GO:0042466 ! chemokinesis
created_by: sl
creation_date: 2015-06-15T22:44:06Z

[Term]
id: GO:1904366
name: negative regulation of chemokinesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chemokinesis." [GO_REF:0000058, GOC:TermGenie, PMID:8679543]
synonym: "down regulation of chemokinesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of chemokinesis" EXACT [GOC:TermGenie]
synonym: "downregulation of chemokinesis" EXACT [GOC:TermGenie]
synonym: "inhibition of chemokinesis" NARROW [GOC:TermGenie]
is_a: GO:0032102 ! negative regulation of response to external stimulus
is_a: GO:1904365 ! regulation of chemokinesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042466 ! chemokinesis
relationship: negatively_regulates GO:0042466 ! chemokinesis
created_by: sl
creation_date: 2015-06-15T22:44:12Z

[Term]
id: GO:1904367
name: positive regulation of chemokinesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chemokinesis." [GO_REF:0000058, GOC:TermGenie, PMID:8679543]
synonym: "activation of chemokinesis" NARROW [GOC:TermGenie]
synonym: "up regulation of chemokinesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of chemokinesis" EXACT [GOC:TermGenie]
synonym: "upregulation of chemokinesis" EXACT [GOC:TermGenie]
is_a: GO:0032103 ! positive regulation of response to external stimulus
is_a: GO:1904365 ! regulation of chemokinesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042466 ! chemokinesis
relationship: positively_regulates GO:0042466 ! chemokinesis
created_by: sl
creation_date: 2015-06-15T22:44:18Z

[Term]
id: GO:1904368
name: regulation of sclerenchyma cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sclerenchyma cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:26025534]
is_a: GO:0045595 ! regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0014001 ! sclerenchyma cell differentiation
relationship: regulates GO:0014001 ! sclerenchyma cell differentiation
created_by: tb
creation_date: 2015-06-17T19:53:00Z

[Term]
id: GO:1904369
name: positive regulation of sclerenchyma cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sclerenchyma cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:26025534]
synonym: "up regulation of sclerenchyma cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of sclerenchyma cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of sclerenchyma cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:1904368 ! regulation of sclerenchyma cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0014001 ! sclerenchyma cell differentiation
relationship: positively_regulates GO:0014001 ! sclerenchyma cell differentiation
created_by: tb
creation_date: 2015-06-17T19:53:06Z

[Term]
id: GO:1904370
name: regulation of protein localization to actin cortical patch
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to actin cortical patch." [GO_REF:0000058, GOC:TermGenie, PMID:18216290]
synonym: "regulation of protein localisation to actin cortical patch" EXACT [GOC:TermGenie]
is_a: GO:1904776 ! regulation of protein localization to cell cortex
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044379 ! protein localization to actin cortical patch
relationship: regulates GO:0044379 ! protein localization to actin cortical patch
created_by: sl
creation_date: 2015-06-18T22:23:31Z

[Term]
id: GO:1904371
name: negative regulation of protein localization to actin cortical patch
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to actin cortical patch." [GO_REF:0000058, GOC:TermGenie, PMID:18216290]
synonym: "down regulation of protein localisation to actin cortical patch" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to actin cortical patch" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation to actin cortical patch" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to actin cortical patch" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation to actin cortical patch" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to actin cortical patch" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localisation to actin cortical patch" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to actin cortical patch" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation to actin cortical patch" EXACT [GOC:TermGenie]
is_a: GO:1904370 ! regulation of protein localization to actin cortical patch
is_a: GO:1904777 ! negative regulation of protein localization to cell cortex
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044379 ! protein localization to actin cortical patch
relationship: negatively_regulates GO:0044379 ! protein localization to actin cortical patch
created_by: sl
creation_date: 2015-06-18T22:23:37Z

[Term]
id: GO:1904372
name: positive regulation of protein localization to actin cortical patch
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to actin cortical patch." [GO_REF:0000058, GOC:TermGenie, PMID:18216290]
synonym: "activation of protein localisation to actin cortical patch" NARROW [GOC:TermGenie]
synonym: "activation of protein localization to actin cortical patch" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein localisation to actin cortical patch" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation to actin cortical patch" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to actin cortical patch" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation to actin cortical patch" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to actin cortical patch" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation to actin cortical patch" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to actin cortical patch" EXACT [GOC:TermGenie]
is_a: GO:1904370 ! regulation of protein localization to actin cortical patch
is_a: GO:1904778 ! positive regulation of protein localization to cell cortex
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044379 ! protein localization to actin cortical patch
relationship: positively_regulates GO:0044379 ! protein localization to actin cortical patch
created_by: sl
creation_date: 2015-06-18T22:23:43Z

[Term]
id: GO:1904373
name: response to kainic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a kainic acid stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:17443789]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0043200 ! response to amino acid
created_by: sl
creation_date: 2015-06-18T22:42:52Z

[Term]
id: GO:1904374
name: cellular response to kainic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a kainic acid stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:17443789]
is_a: GO:0071230 ! cellular response to amino acid stimulus
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1904373 ! response to kainic acid
created_by: sl
creation_date: 2015-06-18T22:42:58Z

[Term]
id: GO:1904375
name: regulation of protein localization to cell periphery
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to cell periphery." [GO_REF:0000058, GOC:TermGenie, PMID:18216290]
is_a: GO:1903827 ! regulation of cellular protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990778 ! protein localization to cell periphery
relationship: regulates GO:1990778 ! protein localization to cell periphery
created_by: sl
creation_date: 2015-06-22T22:09:25Z

[Term]
id: GO:1904376
name: negative regulation of protein localization to cell periphery
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell periphery." [GO_REF:0000058, GOC:TermGenie, PMID:18216290]
synonym: "down regulation of protein localization to cell periphery" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to cell periphery" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to cell periphery" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localization to cell periphery" NARROW [GOC:TermGenie]
is_a: GO:1903828 ! negative regulation of cellular protein localization
is_a: GO:1904375 ! regulation of protein localization to cell periphery
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990778 ! protein localization to cell periphery
relationship: negatively_regulates GO:1990778 ! protein localization to cell periphery
created_by: sl
creation_date: 2015-06-22T22:09:32Z

[Term]
id: GO:1904377
name: positive regulation of protein localization to cell periphery
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to cell periphery." [GO_REF:0000058, GOC:TermGenie, PMID:18216290]
synonym: "activation of protein localization to cell periphery" NARROW [GOC:TermGenie]
synonym: "up regulation of protein localization to cell periphery" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to cell periphery" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to cell periphery" EXACT [GOC:TermGenie]
is_a: GO:1903829 ! positive regulation of cellular protein localization
is_a: GO:1904375 ! regulation of protein localization to cell periphery
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990778 ! protein localization to cell periphery
relationship: positively_regulates GO:1990778 ! protein localization to cell periphery
created_by: sl
creation_date: 2015-06-22T22:09:37Z

[Term]
id: GO:1904378
name: maintenance of unfolded protein involved in ERAD pathway
namespace: biological_process
def: "Maintaining an endoplasmic reticulum (ER) protein in an unfolded, soluble state that contributes to its degradation by the cytoplasmic proteasome. Maintaining ER-resident proteins in an unfolded yet soluble state condition after their retro-translocation favors their turnover by the cytosolic proteasome." [GO_REF:0000060, GOC:bf, GOC:BHF, GOC:nc, GOC:PARL, GOC:TermGenie, PMID:21636303]
synonym: "chaperone holdase activity" RELATED [PMID:23417671]
synonym: "ERAD chaperone-like activity" RELATED [GOC:bf]
synonym: "holdase activity" RELATED [PMID:21636303]
synonym: "maintenance of unfolded protein during ERAD" RELATED [GOC:bf]
synonym: "maintenance of unfolded protein involved in endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "maintenance of unfolded protein involved in endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "maintenance of unfolded protein involved in ER-associated degradation pathway" RELATED [GOC:TermGenie]
is_a: GO:0036506 ! maintenance of unfolded protein
intersection_of: GO:0036506 ! maintenance of unfolded protein
intersection_of: part_of GO:0036503 ! ERAD pathway
relationship: part_of GO:0036503 ! ERAD pathway
created_by: bf
creation_date: 2015-06-23T09:21:53Z

[Term]
id: GO:1904379
name: protein localization to cytosolic proteasome complex involved in ERAD pathway
namespace: biological_process
def: "Any protein localization to cytosolic proteasome complex that is involved in ERAD pathway. Following their retrotranslocation out of the endoplasmic reticulum, protein substrates must be shuttled to the cytosolic proteasome for degradation." [GO_REF:0000060, GOC:bf, GOC:BHF, GOC:nc, GOC:PARL, GOC:TermGenie, PMID:21636303]
synonym: "protein localisation in cytosolic proteasome complex involved in endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "protein localisation in cytosolic proteasome complex involved in endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "protein localisation in cytosolic proteasome complex involved in ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "protein localisation in cytosolic proteasome complex involved in ERAD pathway" EXACT [GOC:TermGenie]
synonym: "protein localisation to cytosolic proteasome complex involved in endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "protein localisation to cytosolic proteasome complex involved in endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "protein localisation to cytosolic proteasome complex involved in ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "protein localisation to cytosolic proteasome complex involved in ERAD pathway" EXACT [GOC:TermGenie]
synonym: "protein localization in cytosolic proteasome complex involved in endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "protein localization in cytosolic proteasome complex involved in endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "protein localization in cytosolic proteasome complex involved in ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "protein localization in cytosolic proteasome complex involved in ERAD pathway" EXACT [GOC:TermGenie]
synonym: "protein localization to cytosolic proteasome complex involved in endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "protein localization to cytosolic proteasome complex involved in endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "protein localization to cytosolic proteasome complex involved in ER-associated degradation pathway" RELATED [GOC:TermGenie]
is_a: GO:1904327 ! protein localization to cytosolic proteasome complex
intersection_of: GO:1904327 ! protein localization to cytosolic proteasome complex
intersection_of: part_of GO:0036503 ! ERAD pathway
relationship: part_of GO:0036503 ! ERAD pathway
created_by: bf
creation_date: 2015-06-23T09:30:07Z

[Term]
id: GO:1904380
name: endoplasmic reticulum mannose trimming
namespace: biological_process
def: "Any protein alpha-1,2-demannosylation that takes place in the endoplasmic reticulum quality control compartment (ERQC)." [GO_REF:0000062, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24519966]
synonym: "ER mannose trimming" EXACT [GOC:bf]
synonym: "ER protein alpha-1,2-demannosylation" EXACT [GOC:bf]
synonym: "glycoprotein mannose trimming in endoplasmic reticulum quality control compartment" RELATED [GOC:TermGenie]
synonym: "glycoprotein mannose trimming in ER quality control compartment" RELATED [GOC:TermGenie]
synonym: "glycoprotein mannose trimming in ER-derived quality control compartment" RELATED [GOC:TermGenie]
synonym: "glycoprotein mannose trimming in ERQC" RELATED [GOC:TermGenie]
synonym: "protein alpha-1,2-demannosylation in endoplasmic reticulum" EXACT [GOC:bf]
synonym: "protein alpha-1,2-demannosylation in endoplasmic reticulum quality control compartment" EXACT [GOC:bf]
synonym: "protein alpha-1,2-demannosylation in ER" EXACT [GOC:bf]
synonym: "protein alpha-1,2-demannosylation in ER quality control compartment" EXACT [GOC:TermGenie]
synonym: "protein alpha-1,2-demannosylation in ER-derived quality control compartment" RELATED [GOC:TermGenie]
synonym: "protein alpha-1,2-demannosylation in ERQC" EXACT [GOC:TermGenie]
is_a: GO:0036508 ! protein alpha-1,2-demannosylation
intersection_of: GO:0036508 ! protein alpha-1,2-demannosylation
intersection_of: occurs_in GO:0044322 ! endoplasmic reticulum quality control compartment
relationship: occurs_in GO:0044322 ! endoplasmic reticulum quality control compartment
created_by: bf
creation_date: 2015-06-23T09:35:41Z

[Term]
id: GO:1904381
name: Golgi apparatus mannose trimming
namespace: biological_process
def: "Any protein alpha-1,2-demannosylation that takes place in the Golgi apparatus." [GO_REF:0000062, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:10915796]
synonym: "glycoprotein mannose trimming in Golgi apparatus" RELATED [GOC:TermGenie]
synonym: "glycoprotein mannose trimming in Golgi complex" RELATED [GOC:TermGenie]
synonym: "glycoprotein mannose trimming in Golgi ribbon" RELATED [GOC:TermGenie]
synonym: "mannose trimming in cis-Golgi" NARROW [GOC:bf]
synonym: "mannose trimming in Golgi" BROAD [GOC:TermGenie]
synonym: "mannose trimming in Golgi apparatus" EXACT [GOC:bf]
synonym: "protein alpha-1,2-demannosylation in Golgi apparatus" EXACT [GOC:bf]
synonym: "protein alpha-1,2-demannosylation in Golgi complex" EXACT [GOC:TermGenie]
synonym: "protein alpha-1,2-demannosylation in Golgi ribbon" NARROW [GOC:TermGenie]
is_a: GO:0036508 ! protein alpha-1,2-demannosylation
intersection_of: GO:0036508 ! protein alpha-1,2-demannosylation
intersection_of: occurs_in GO:0005794 ! Golgi apparatus
relationship: occurs_in GO:0005794 ! Golgi apparatus
created_by: bf
creation_date: 2015-06-23T09:42:06Z

[Term]
id: GO:1904382
name: mannose trimming involved in glycoprotein ERAD pathway
namespace: biological_process
def: "The removal of one or more alpha 1,2-linked mannose residues from a mannosylated protein that occurs as part of glycoprotein ER-associated glycoprotein degradation (gpERAD)." [GO_REF:0000060, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24519966]
synonym: "glycoprotein mannose trimming involved in ER-associated glycoprotein degradation" RELATED [GOC:TermGenie]
synonym: "glycoprotein mannose trimming involved in glycoprotein ERAD" RELATED [GOC:TermGenie]
synonym: "glycoprotein mannose trimming involved in glycoprotein ERAD pathway" RELATED [GOC:TermGenie]
synonym: "glycoprotein mannose trimming involved in gpERAD" RELATED [GOC:TermGenie]
synonym: "mannose trimming involved in misfolded or incompletely synthesized glycoprotein catabolic process" BROAD [GOC:TermGenie]
synonym: "protein alpha-1,2-demannosylation involved in ER-associated glycoprotein degradation" EXACT [GOC:TermGenie]
synonym: "protein alpha-1,2-demannosylation involved in glycoprotein ERAD" EXACT [GOC:TermGenie]
synonym: "protein alpha-1,2-demannosylation involved in glycoprotein ERAD pathway" EXACT [GOC:bf]
synonym: "protein alpha-1,2-demannosylation involved in gpERAD" EXACT [GOC:TermGenie]
is_a: GO:0035977 ! protein deglycosylation involved in glycoprotein catabolic process
is_a: GO:0036508 ! protein alpha-1,2-demannosylation
intersection_of: GO:0036508 ! protein alpha-1,2-demannosylation
intersection_of: part_of GO:0097466 ! glycoprotein ERAD pathway
relationship: part_of GO:0097466 ! glycoprotein ERAD pathway
created_by: bf
creation_date: 2015-06-23T09:46:55Z

[Term]
id: GO:1904383
name: response to sodium phosphate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium phosphate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24625659]
is_a: GO:0010035 ! response to inorganic substance
is_a: GO:1902074 ! response to salt
created_by: sl
creation_date: 2015-06-23T16:55:07Z

[Term]
id: GO:1904384
name: cellular response to sodium phosphate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium phosphate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24625659]
is_a: GO:1902075 ! cellular response to salt
is_a: GO:1904383 ! response to sodium phosphate
created_by: sl
creation_date: 2015-06-23T16:55:13Z

[Term]
id: GO:1904385
name: cellular response to angiotensin
namespace: biological_process
def: "\"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an angiotensin stimulus. Angiotensin is any of three physiologically active peptides (angiotensin II, III, or IV) processed from angiotensinogen.\"" [GO_REF:0000071, GOC:TermGenie, PMID:22982863]
is_a: GO:0071375 ! cellular response to peptide hormone stimulus
is_a: GO:1990776 ! response to angiotensin
created_by: sl
creation_date: 2015-06-23T17:27:14Z

[Term]
id: GO:1904386
name: response to L-phenylalanine derivative
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-phenylalanine derivative stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:12112407]
is_a: GO:0010243 ! response to organonitrogen compound
created_by: sl
creation_date: 2015-06-23T17:56:19Z

[Term]
id: GO:1904387
name: cellular response to L-phenylalanine derivative
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-phenylalanine derivative stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:12112407]
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:1904386 ! response to L-phenylalanine derivative
created_by: sl
creation_date: 2015-06-23T17:56:25Z

[Term]
id: GO:1904388
name: negative regulation of ncRNA transcription associated with protein coding gene TSS/TES
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ncRNA transcription associated with protein coding gene TSS/TES." [GO_REF:0000058, GOC:TermGenie, PMID:20502517]
synonym: "down regulation of ncRNA transcription associated with protein coding gene TSS/TES" EXACT [GOC:TermGenie]
synonym: "down regulation of pasRNA transcription" NARROW [GOC:TermGenie]
synonym: "down-regulation of ncRNA transcription associated with protein coding gene TSS/TES" EXACT [GOC:TermGenie]
synonym: "down-regulation of pasRNA transcription" NARROW [GOC:TermGenie]
synonym: "downregulation of ncRNA transcription associated with protein coding gene TSS/TES" EXACT [GOC:TermGenie]
synonym: "downregulation of pasRNA transcription" NARROW [GOC:TermGenie]
synonym: "inhibition of ncRNA transcription associated with protein coding gene TSS/TES" NARROW [GOC:TermGenie]
synonym: "inhibition of pasRNA transcription" NARROW [GOC:TermGenie]
synonym: "negative regulation of pasRNA transcription" NARROW [GOC:TermGenie]
is_a: GO:0045892 ! negative regulation of transcription, DNA-templated
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0098790 ! ncRNA transcription associated with protein coding gene TSS/TES
relationship: negatively_regulates GO:0098790 ! ncRNA transcription associated with protein coding gene TSS/TES
created_by: dos
creation_date: 2015-06-23T18:11:39Z

[Term]
id: GO:1904389
name: rod bipolar cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a rod bipolar cell." [GO_REF:0000086, GOC:TermGenie, PMID:16914133]
is_a: GO:0060040 ! retinal bipolar neuron differentiation
created_by: sl
creation_date: 2015-06-23T19:01:11Z

[Term]
id: GO:1904390
name: cone retinal bipolar cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a cone retinal bipolar cell." [GO_REF:0000086, GOC:TermGenie, PMID:24123365]
synonym: "cone bipolar cell differentiation" EXACT [PMID:14745032]
synonym: "retinal cone bipolar cell differentiation" EXACT []
is_a: GO:0060040 ! retinal bipolar neuron differentiation
created_by: sl
creation_date: 2015-06-23T19:01:16Z

[Term]
id: GO:1904391
name: response to ciliary neurotrophic factor
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ciliary neurotrophic factor stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16914133]
is_a: GO:0042221 ! response to chemical
created_by: sl
creation_date: 2015-06-23T19:13:04Z

[Term]
id: GO:1904392
name: cellular response to ciliary neurotrophic factor
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ciliary neurotrophic factor stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16914133]
is_a: GO:0070887 ! cellular response to chemical stimulus
is_a: GO:1904391 ! response to ciliary neurotrophic factor
created_by: sl
creation_date: 2015-06-23T19:13:10Z

[Term]
id: GO:1904393
name: regulation of skeletal muscle acetylcholine-gated channel clustering
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle acetylcholine-gated channel clustering." [GO_REF:0000058, GOC:TermGenie, PMID:7722643]
synonym: "regulation of skeletal muscle AChR clustering" EXACT [GOC:TermGenie]
synonym: "regulation of skeletal muscle nicotinic acetylcholine receptor clustering" EXACT [GOC:TermGenie]
is_a: GO:1901626 ! regulation of postsynaptic membrane organization
is_a: GO:1903909 ! regulation of receptor clustering
is_a: GO:1904396 ! regulation of neuromuscular junction development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071340 ! skeletal muscle acetylcholine-gated channel clustering
relationship: regulates GO:0071340 ! skeletal muscle acetylcholine-gated channel clustering
created_by: sl
creation_date: 2015-06-23T19:23:25Z

[Term]
id: GO:1904394
name: negative regulation of skeletal muscle acetylcholine-gated channel clustering
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle acetylcholine-gated channel clustering." [GO_REF:0000058, GOC:TermGenie, PMID:7722643]
synonym: "down regulation of skeletal muscle acetylcholine-gated channel clustering" EXACT [GOC:TermGenie]
synonym: "down regulation of skeletal muscle AChR clustering" EXACT [GOC:TermGenie]
synonym: "down regulation of skeletal muscle nicotinic acetylcholine receptor clustering" EXACT [GOC:TermGenie]
synonym: "down-regulation of skeletal muscle acetylcholine-gated channel clustering" EXACT [GOC:TermGenie]
synonym: "down-regulation of skeletal muscle AChR clustering" EXACT [GOC:TermGenie]
synonym: "down-regulation of skeletal muscle nicotinic acetylcholine receptor clustering" EXACT [GOC:TermGenie]
synonym: "downregulation of skeletal muscle acetylcholine-gated channel clustering" EXACT [GOC:TermGenie]
synonym: "downregulation of skeletal muscle AChR clustering" EXACT [GOC:TermGenie]
synonym: "downregulation of skeletal muscle nicotinic acetylcholine receptor clustering" EXACT [GOC:TermGenie]
synonym: "inhibition of skeletal muscle acetylcholine-gated channel clustering" NARROW [GOC:TermGenie]
synonym: "inhibition of skeletal muscle AChR clustering" NARROW [GOC:TermGenie]
synonym: "inhibition of skeletal muscle nicotinic acetylcholine receptor clustering" NARROW [GOC:TermGenie]
synonym: "negative regulation of skeletal muscle AChR clustering" EXACT [GOC:TermGenie]
synonym: "negative regulation of skeletal muscle nicotinic acetylcholine receptor clustering" EXACT [GOC:TermGenie]
is_a: GO:1901627 ! negative regulation of postsynaptic membrane organization
is_a: GO:1903910 ! negative regulation of receptor clustering
is_a: GO:1904393 ! regulation of skeletal muscle acetylcholine-gated channel clustering
is_a: GO:1904397 ! negative regulation of neuromuscular junction development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071340 ! skeletal muscle acetylcholine-gated channel clustering
relationship: negatively_regulates GO:0071340 ! skeletal muscle acetylcholine-gated channel clustering
created_by: sl
creation_date: 2015-06-23T19:23:31Z

[Term]
id: GO:1904395
name: positive regulation of skeletal muscle acetylcholine-gated channel clustering
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of skeletal muscle acetylcholine-gated channel clustering." [GO_REF:0000058, GOC:TermGenie, PMID:7722643]
synonym: "activation of skeletal muscle acetylcholine-gated channel clustering" NARROW [GOC:TermGenie]
synonym: "activation of skeletal muscle AChR clustering" NARROW [GOC:TermGenie]
synonym: "activation of skeletal muscle nicotinic acetylcholine receptor clustering" NARROW [GOC:TermGenie]
synonym: "positive regulation of skeletal muscle AChR clustering" EXACT [GOC:TermGenie]
synonym: "positive regulation of skeletal muscle nicotinic acetylcholine receptor clustering" EXACT [GOC:TermGenie]
synonym: "up regulation of skeletal muscle acetylcholine-gated channel clustering" EXACT [GOC:TermGenie]
synonym: "up regulation of skeletal muscle AChR clustering" EXACT [GOC:TermGenie]
synonym: "up regulation of skeletal muscle nicotinic acetylcholine receptor clustering" EXACT [GOC:TermGenie]
synonym: "up-regulation of skeletal muscle acetylcholine-gated channel clustering" EXACT [GOC:TermGenie]
synonym: "up-regulation of skeletal muscle AChR clustering" EXACT [GOC:TermGenie]
synonym: "up-regulation of skeletal muscle nicotinic acetylcholine receptor clustering" EXACT [GOC:TermGenie]
synonym: "upregulation of skeletal muscle acetylcholine-gated channel clustering" EXACT [GOC:TermGenie]
synonym: "upregulation of skeletal muscle AChR clustering" EXACT [GOC:TermGenie]
synonym: "upregulation of skeletal muscle nicotinic acetylcholine receptor clustering" EXACT [GOC:TermGenie]
is_a: GO:1901628 ! positive regulation of postsynaptic membrane organization
is_a: GO:1903911 ! positive regulation of receptor clustering
is_a: GO:1904393 ! regulation of skeletal muscle acetylcholine-gated channel clustering
is_a: GO:1904398 ! positive regulation of neuromuscular junction development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071340 ! skeletal muscle acetylcholine-gated channel clustering
relationship: positively_regulates GO:0071340 ! skeletal muscle acetylcholine-gated channel clustering
created_by: sl
creation_date: 2015-06-23T19:23:37Z

[Term]
id: GO:1904396
name: regulation of neuromuscular junction development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neuromuscular junction development." [GO_REF:0000058, GOC:TermGenie, PMID:7722643]
synonym: "regulation of neuromuscular junction organization" EXACT [GOC:TermGenie]
synonym: "regulation of neuromuscular junction stability" RELATED [GOC:TermGenie]
synonym: "regulation of NMJ stability" RELATED [GOC:TermGenie]
is_a: GO:0050807 ! regulation of synapse organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007528 ! neuromuscular junction development
relationship: regulates GO:0007528 ! neuromuscular junction development
created_by: sl
creation_date: 2015-06-23T19:23:42Z

[Term]
id: GO:1904397
name: negative regulation of neuromuscular junction development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuromuscular junction development." [GO_REF:0000058, GOC:TermGenie, PMID:7722643]
synonym: "down regulation of neuromuscular junction development" EXACT [GOC:TermGenie]
synonym: "down regulation of neuromuscular junction organization" EXACT [GOC:TermGenie]
synonym: "down regulation of neuromuscular junction stability" RELATED [GOC:TermGenie]
synonym: "down regulation of NMJ stability" RELATED [GOC:TermGenie]
synonym: "down-regulation of neuromuscular junction development" EXACT [GOC:TermGenie]
synonym: "down-regulation of neuromuscular junction organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of neuromuscular junction stability" RELATED [GOC:TermGenie]
synonym: "down-regulation of NMJ stability" RELATED [GOC:TermGenie]
synonym: "downregulation of neuromuscular junction development" EXACT [GOC:TermGenie]
synonym: "downregulation of neuromuscular junction organization" EXACT [GOC:TermGenie]
synonym: "downregulation of neuromuscular junction stability" RELATED [GOC:TermGenie]
synonym: "downregulation of NMJ stability" RELATED [GOC:TermGenie]
synonym: "inhibition of neuromuscular junction development" NARROW [GOC:TermGenie]
synonym: "inhibition of neuromuscular junction organization" NARROW [GOC:TermGenie]
synonym: "inhibition of neuromuscular junction stability" RELATED [GOC:TermGenie]
synonym: "inhibition of NMJ stability" RELATED [GOC:TermGenie]
synonym: "negative regulation of neuromuscular junction organization" EXACT [GOC:TermGenie]
synonym: "negative regulation of neuromuscular junction stability" RELATED [GOC:TermGenie]
synonym: "negative regulation of NMJ stability" RELATED [GOC:TermGenie]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1904396 ! regulation of neuromuscular junction development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007528 ! neuromuscular junction development
relationship: negatively_regulates GO:0007528 ! neuromuscular junction development
created_by: sl
creation_date: 2015-06-23T19:23:48Z

[Term]
id: GO:1904398
name: positive regulation of neuromuscular junction development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neuromuscular junction development." [GO_REF:0000058, GOC:TermGenie, PMID:7722643]
synonym: "activation of neuromuscular junction development" NARROW [GOC:TermGenie]
synonym: "activation of neuromuscular junction organization" NARROW [GOC:TermGenie]
synonym: "activation of neuromuscular junction stability" RELATED [GOC:TermGenie]
synonym: "activation of NMJ stability" RELATED [GOC:TermGenie]
synonym: "positive regulation of neuromuscular junction organization" EXACT [GOC:TermGenie]
synonym: "positive regulation of neuromuscular junction stability" RELATED [GOC:TermGenie]
synonym: "positive regulation of NMJ stability" RELATED [GOC:TermGenie]
synonym: "up regulation of neuromuscular junction development" EXACT [GOC:TermGenie]
synonym: "up regulation of neuromuscular junction organization" EXACT [GOC:TermGenie]
synonym: "up regulation of neuromuscular junction stability" RELATED [GOC:TermGenie]
synonym: "up regulation of NMJ stability" RELATED [GOC:TermGenie]
synonym: "up-regulation of neuromuscular junction development" EXACT [GOC:TermGenie]
synonym: "up-regulation of neuromuscular junction organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of neuromuscular junction stability" RELATED [GOC:TermGenie]
synonym: "up-regulation of NMJ stability" RELATED [GOC:TermGenie]
synonym: "upregulation of neuromuscular junction development" EXACT [GOC:TermGenie]
synonym: "upregulation of neuromuscular junction organization" EXACT [GOC:TermGenie]
synonym: "upregulation of neuromuscular junction stability" RELATED [GOC:TermGenie]
synonym: "upregulation of NMJ stability" RELATED [GOC:TermGenie]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1904396 ! regulation of neuromuscular junction development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007528 ! neuromuscular junction development
relationship: positively_regulates GO:0007528 ! neuromuscular junction development
created_by: sl
creation_date: 2015-06-23T19:23:54Z

[Term]
id: GO:1904399
name: heparan sulfate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with heparan sulfate." [GO_REF:0000067, GOC:TermGenie, PMID:8567685]
is_a: GO:0005539 ! glycosaminoglycan binding
is_a: GO:0043168 ! anion binding
is_a: GO:1901681 ! sulfur compound binding
created_by: sl
creation_date: 2015-06-23T19:56:54Z

[Term]
id: GO:1904400
name: response to Thyroid stimulating hormone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Thyroid stimulating hormone stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:11238928]
is_a: GO:0010033 ! response to organic substance
created_by: sl
creation_date: 2015-06-23T20:57:53Z

[Term]
id: GO:1904401
name: cellular response to Thyroid stimulating hormone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Thyroid stimulating hormone stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:11238928]
is_a: GO:0070887 ! cellular response to chemical stimulus
is_a: GO:1904400 ! response to Thyroid stimulating hormone
created_by: sl
creation_date: 2015-06-23T20:57:59Z

[Term]
id: GO:1904402
name: response to nocodazole
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nocodazole stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:17822405]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901654 ! response to ketone
created_by: sl
creation_date: 2015-06-23T21:10:45Z

[Term]
id: GO:1904403
name: cellular response to nocodazole
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nocodazole stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:17822405]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:1901655 ! cellular response to ketone
is_a: GO:1904402 ! response to nocodazole
created_by: sl
creation_date: 2015-06-23T21:10:52Z

[Term]
id: GO:1904404
name: response to formaldehyde
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a formaldehyde stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:9149109]
is_a: GO:0010033 ! response to organic substance
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: sl
creation_date: 2015-06-23T21:14:04Z

[Term]
id: GO:1904405
name: cellular response to formaldehyde
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a formaldehyde stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:9149109]
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1904404 ! response to formaldehyde
created_by: sl
creation_date: 2015-06-23T21:14:10Z

[Term]
id: GO:1904406
name: negative regulation of nitric oxide metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of nitric oxide metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:11991626]
synonym: "down regulation of nitric oxide metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of nitric oxide metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of nitric oxide metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of nitric oxide metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of nitric oxide metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of nitric oxide metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of nitric oxide metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of nitric oxide metabolism" NARROW [GOC:TermGenie]
synonym: "negative regulation of nitric oxide metabolism" EXACT [GOC:TermGenie]
is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process
is_a: GO:2000378 ! negative regulation of reactive oxygen species metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0046209 ! nitric oxide metabolic process
relationship: negatively_regulates GO:0046209 ! nitric oxide metabolic process
created_by: sl
creation_date: 2015-06-24T20:56:41Z

[Term]
id: GO:1904407
name: positive regulation of nitric oxide metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of nitric oxide metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:11991626]
synonym: "activation of nitric oxide metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of nitric oxide metabolism" NARROW [GOC:TermGenie]
synonym: "positive regulation of nitric oxide metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of nitric oxide metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of nitric oxide metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of nitric oxide metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of nitric oxide metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of nitric oxide metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of nitric oxide metabolism" EXACT [GOC:TermGenie]
is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process
is_a: GO:2000379 ! positive regulation of reactive oxygen species metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0046209 ! nitric oxide metabolic process
relationship: positively_regulates GO:0046209 ! nitric oxide metabolic process
created_by: sl
creation_date: 2015-06-24T20:56:47Z

[Term]
id: GO:1904408
name: melatonin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with melatonin." [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:10379923]
is_a: GO:0033218 ! amide binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding
created_by: mr
creation_date: 2015-06-25T19:19:53Z

[Term]
id: GO:1904409
name: regulation of secretory granule organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of secretory granule organization." [GO_REF:0000058, GOC:TermGenie, PMID:15039777]
synonym: "regulation of secretory granule organisation" EXACT [GOC:TermGenie]
synonym: "regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0033043 ! regulation of organelle organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0033363 ! secretory granule organization
relationship: regulates GO:0033363 ! secretory granule organization
created_by: sl
creation_date: 2015-06-25T19:40:42Z

[Term]
id: GO:1904410
name: negative regulation of secretory granule organization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of secretory granule organization." [GO_REF:0000058, GOC:TermGenie, PMID:15039777]
synonym: "down regulation of secretory granule organisation" EXACT [GOC:TermGenie]
synonym: "down regulation of secretory granule organization" EXACT [GOC:TermGenie]
synonym: "down regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of secretory granule organisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of secretory granule organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "downregulation of secretory granule organisation" EXACT [GOC:TermGenie]
synonym: "downregulation of secretory granule organization" EXACT [GOC:TermGenie]
synonym: "downregulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "inhibition of secretory granule organisation" NARROW [GOC:TermGenie]
synonym: "inhibition of secretory granule organization" NARROW [GOC:TermGenie]
synonym: "inhibition of secretory granule organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of secretory granule organisation" EXACT [GOC:TermGenie]
synonym: "negative regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:1904409 ! regulation of secretory granule organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0033363 ! secretory granule organization
relationship: negatively_regulates GO:0033363 ! secretory granule organization
created_by: sl
creation_date: 2015-06-25T19:40:49Z

[Term]
id: GO:1904411
name: positive regulation of secretory granule organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of secretory granule organization." [GO_REF:0000058, GOC:TermGenie, PMID:15039777]
synonym: "activation of secretory granule organisation" NARROW [GOC:TermGenie]
synonym: "activation of secretory granule organization" NARROW [GOC:TermGenie]
synonym: "activation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of secretory granule organisation" EXACT [GOC:TermGenie]
synonym: "positive regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "up regulation of secretory granule organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of secretory granule organization" EXACT [GOC:TermGenie]
synonym: "up regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of secretory granule organisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of secretory granule organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "upregulation of secretory granule organisation" EXACT [GOC:TermGenie]
synonym: "upregulation of secretory granule organization" EXACT [GOC:TermGenie]
synonym: "upregulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:1904409 ! regulation of secretory granule organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0033363 ! secretory granule organization
relationship: positively_regulates GO:0033363 ! secretory granule organization
created_by: sl
creation_date: 2015-06-25T19:40:55Z

[Term]
id: GO:1904412
name: regulation of cardiac ventricle development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac ventricle development." [GO_REF:0000058, GOC:TermGenie, PMID:19590510]
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003231 ! cardiac ventricle development
relationship: regulates GO:0003231 ! cardiac ventricle development
created_by: sl
creation_date: 2015-06-25T19:52:15Z

[Term]
id: GO:1904413
name: negative regulation of cardiac ventricle development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac ventricle development." [GO_REF:0000058, GOC:TermGenie, PMID:19590510]
synonym: "down regulation of cardiac ventricle development" EXACT [GOC:TermGenie]
synonym: "down-regulation of cardiac ventricle development" EXACT [GOC:TermGenie]
synonym: "downregulation of cardiac ventricle development" EXACT [GOC:TermGenie]
synonym: "inhibition of cardiac ventricle development" NARROW [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1904412 ! regulation of cardiac ventricle development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003231 ! cardiac ventricle development
relationship: negatively_regulates GO:0003231 ! cardiac ventricle development
created_by: sl
creation_date: 2015-06-25T19:52:21Z

[Term]
id: GO:1904414
name: positive regulation of cardiac ventricle development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiac ventricle development." [GO_REF:0000058, GOC:TermGenie, PMID:19590510]
synonym: "activation of cardiac ventricle development" NARROW [GOC:TermGenie]
synonym: "up regulation of cardiac ventricle development" EXACT [GOC:TermGenie]
synonym: "up-regulation of cardiac ventricle development" EXACT [GOC:TermGenie]
synonym: "upregulation of cardiac ventricle development" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1904412 ! regulation of cardiac ventricle development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003231 ! cardiac ventricle development
relationship: positively_regulates GO:0003231 ! cardiac ventricle development
created_by: sl
creation_date: 2015-06-25T19:52:27Z

[Term]
id: GO:1904415
name: regulation of xenophagy
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of xenophagy." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:21617041]
comment: An example of this is mouse Tbk1 (UniProt symbol, Q9WUN2) in PMID:21617041 (inferred from mutant phenotype).
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0016241 ! regulation of macroautophagy
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0043900 ! regulation of multi-organism process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0098792 ! xenophagy
relationship: regulates GO:0098792 ! xenophagy
created_by: pad
creation_date: 2015-06-29T12:30:47Z

[Term]
id: GO:1904416
name: negative regulation of xenophagy
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of xenophagy." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:21617041]
comment: An example of this is mouse Tbk1 (UniProt symbol, Q9WUN2) in PMID:21617041 (inferred from mutant phenotype).
synonym: "down regulation of xenophagy" EXACT [GOC:TermGenie]
synonym: "down-regulation of xenophagy" EXACT [GOC:TermGenie]
synonym: "downregulation of xenophagy" EXACT [GOC:TermGenie]
synonym: "inhibition of xenophagy" NARROW [GOC:TermGenie]
is_a: GO:0002832 ! negative regulation of response to biotic stimulus
is_a: GO:0016242 ! negative regulation of macroautophagy
is_a: GO:0031348 ! negative regulation of defense response
is_a: GO:0043901 ! negative regulation of multi-organism process
is_a: GO:1904415 ! regulation of xenophagy
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0098792 ! xenophagy
relationship: negatively_regulates GO:0098792 ! xenophagy
created_by: pad
creation_date: 2015-06-29T12:30:53Z

[Term]
id: GO:1904417
name: positive regulation of xenophagy
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of xenophagy." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:21617041]
comment: An example of this is mouse Tbk1 (UniProt symbol, Q9WUN2) in PMID:21617041 (inferred from mutant phenotype).
synonym: "activation of xenophagy" NARROW [GOC:TermGenie]
synonym: "up regulation of xenophagy" EXACT [GOC:TermGenie]
synonym: "up-regulation of xenophagy" EXACT [GOC:TermGenie]
synonym: "upregulation of xenophagy" EXACT [GOC:TermGenie]
is_a: GO:0002833 ! positive regulation of response to biotic stimulus
is_a: GO:0016239 ! positive regulation of macroautophagy
is_a: GO:0031349 ! positive regulation of defense response
is_a: GO:0043902 ! positive regulation of multi-organism process
is_a: GO:1904415 ! regulation of xenophagy
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0098792 ! xenophagy
relationship: positively_regulates GO:0098792 ! xenophagy
created_by: pad
creation_date: 2015-06-29T12:30:59Z

[Term]
id: GO:1904418
name: regulation of telomeric loop formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of telomeric loop formation." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284]
synonym: "regulation of t-loop biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of t-loop formation" EXACT [GOC:TermGenie]
is_a: GO:0032204 ! regulation of telomere maintenance
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031627 ! telomeric loop formation
relationship: regulates GO:0031627 ! telomeric loop formation
created_by: nc
creation_date: 2015-07-01T10:40:24Z

[Term]
id: GO:1904419
name: negative regulation of telomeric loop formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of telomeric loop formation." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284]
synonym: "down regulation of t-loop biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of t-loop formation" EXACT [GOC:TermGenie]
synonym: "down regulation of telomeric loop formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of t-loop biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of t-loop formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of telomeric loop formation" EXACT [GOC:TermGenie]
synonym: "downregulation of t-loop biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of t-loop formation" EXACT [GOC:TermGenie]
synonym: "downregulation of telomeric loop formation" EXACT [GOC:TermGenie]
synonym: "inhibition of t-loop biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of t-loop formation" NARROW [GOC:TermGenie]
synonym: "inhibition of telomeric loop formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of t-loop biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of t-loop formation" EXACT [GOC:TermGenie]
is_a: GO:0032205 ! negative regulation of telomere maintenance
is_a: GO:1904418 ! regulation of telomeric loop formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0031627 ! telomeric loop formation
relationship: negatively_regulates GO:0031627 ! telomeric loop formation
created_by: nc
creation_date: 2015-07-01T10:40:29Z

[Term]
id: GO:1904420
name: positive regulation of telomeric loop formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of telomeric loop formation." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284]
synonym: "activation of t-loop biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of t-loop formation" NARROW [GOC:TermGenie]
synonym: "activation of telomeric loop formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of t-loop biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of t-loop formation" EXACT [GOC:TermGenie]
synonym: "up regulation of t-loop biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of t-loop formation" EXACT [GOC:TermGenie]
synonym: "up regulation of telomeric loop formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of t-loop biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of t-loop formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of telomeric loop formation" EXACT [GOC:TermGenie]
synonym: "upregulation of t-loop biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of t-loop formation" EXACT [GOC:TermGenie]
synonym: "upregulation of telomeric loop formation" EXACT [GOC:TermGenie]
is_a: GO:0032206 ! positive regulation of telomere maintenance
is_a: GO:1904418 ! regulation of telomeric loop formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0031627 ! telomeric loop formation
relationship: positively_regulates GO:0031627 ! telomeric loop formation
created_by: nc
creation_date: 2015-07-01T10:40:35Z

[Term]
id: GO:1904421
name: response to D-galactosamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a D-galactosamine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:12057922]
is_a: GO:0010033 ! response to organic substance
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: sl
creation_date: 2015-07-02T15:38:20Z

[Term]
id: GO:1904422
name: cellular response to D-galactosamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a D-galactosamine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:12057922]
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1904421 ! response to D-galactosamine
created_by: sl
creation_date: 2015-07-02T15:38:36Z

[Term]
id: GO:1904423
name: dehydrodolichyl diphosphate synthase complex
namespace: cellular_component
def: "A protein complex which is capable of dehydrodolichyl diphosphate synthase activity." [GO_REF:0000088, GOC:TermGenie, PMID:25066056]
is_a: GO:1990234 ! transferase complex
created_by: ew
creation_date: 2015-07-02T19:51:40Z

[Term]
id: GO:1904424
name: regulation of GTP binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of GTP binding." [GO_REF:0000059, GOC:TermGenie, PMID:19066305, PMID:21454546]
is_a: GO:0051098 ! regulation of binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0005525 ! GTP binding
relationship: regulates GO:0005525 ! GTP binding
created_by: sl
creation_date: 2015-07-02T20:34:44Z

[Term]
id: GO:1904425
name: negative regulation of GTP binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of GTP binding." [GO_REF:0000059, GOC:TermGenie, PMID:19066305, PMID:21454546]
synonym: "down regulation of GTP binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of GTP binding" EXACT [GOC:TermGenie]
synonym: "downregulation of GTP binding" EXACT [GOC:TermGenie]
synonym: "inhibition of GTP binding" NARROW [GOC:TermGenie]
is_a: GO:0051100 ! negative regulation of binding
is_a: GO:1904424 ! regulation of GTP binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0005525 ! GTP binding
relationship: negatively_regulates GO:0005525 ! GTP binding
created_by: sl
creation_date: 2015-07-02T20:35:01Z

[Term]
id: GO:1904426
name: positive regulation of GTP binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of GTP binding." [GO_REF:0000059, GOC:TermGenie, PMID:19066305, PMID:21454546]
synonym: "activation of GTP binding" NARROW [GOC:TermGenie]
synonym: "up regulation of GTP binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of GTP binding" EXACT [GOC:TermGenie]
synonym: "upregulation of GTP binding" EXACT [GOC:TermGenie]
is_a: GO:0051099 ! positive regulation of binding
is_a: GO:1904424 ! regulation of GTP binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0005525 ! GTP binding
relationship: positively_regulates GO:0005525 ! GTP binding
created_by: sl
creation_date: 2015-07-02T20:35:07Z

[Term]
id: GO:1904427
name: positive regulation of calcium ion transmembrane transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of calcium ion transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:22910094]
synonym: "activation of calcium ion membrane transport" NARROW [GOC:TermGenie]
synonym: "activation of calcium ion transmembrane transport" NARROW [GOC:TermGenie]
synonym: "activation of transmembrane calcium transport" NARROW [GOC:TermGenie]
synonym: "positive regulation of calcium ion membrane transport" EXACT [GOC:TermGenie]
synonym: "positive regulation of transmembrane calcium transport" EXACT [GOC:TermGenie]
synonym: "up regulation of calcium ion membrane transport" EXACT [GOC:TermGenie]
synonym: "up regulation of calcium ion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "up regulation of transmembrane calcium transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of calcium ion membrane transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of calcium ion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of transmembrane calcium transport" EXACT [GOC:TermGenie]
synonym: "upregulation of calcium ion membrane transport" EXACT [GOC:TermGenie]
synonym: "upregulation of calcium ion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "upregulation of transmembrane calcium transport" EXACT [GOC:TermGenie]
is_a: GO:0051928 ! positive regulation of calcium ion transport
is_a: GO:1903169 ! regulation of calcium ion transmembrane transport
is_a: GO:1904064 ! positive regulation of cation transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070588 ! calcium ion transmembrane transport
relationship: positively_regulates GO:0070588 ! calcium ion transmembrane transport
created_by: sl
creation_date: 2015-07-02T20:44:25Z

[Term]
id: GO:1904428
name: negative regulation of tubulin deacetylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tubulin deacetylation." [GO_REF:0000058, GOC:TermGenie, PMID:23886946]
synonym: "down regulation of tubulin deacetylation" EXACT [GOC:TermGenie]
synonym: "down-regulation of tubulin deacetylation" EXACT [GOC:TermGenie]
synonym: "downregulation of tubulin deacetylation" EXACT [GOC:TermGenie]
synonym: "inhibition of tubulin deacetylation" NARROW [GOC:TermGenie]
is_a: GO:0031400 ! negative regulation of protein modification process
is_a: GO:0090043 ! regulation of tubulin deacetylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0090042 ! tubulin deacetylation
relationship: negatively_regulates GO:0090042 ! tubulin deacetylation
created_by: sart
creation_date: 2015-07-03T14:42:58Z

[Term]
id: GO:1904429
name: regulation of t-circle formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of t-circle formation." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284]
synonym: "regulation of telomeric circle formation" EXACT [GOC:TermGenie]
is_a: GO:0032204 ! regulation of telomere maintenance
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0090656 ! t-circle formation
relationship: regulates GO:0090656 ! t-circle formation
created_by: nc
creation_date: 2015-07-03T15:15:45Z

[Term]
id: GO:1904430
name: negative regulation of t-circle formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of t-circle formation." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284]
synonym: "down regulation of t-circle formation" EXACT [GOC:TermGenie]
synonym: "down regulation of telomeric circle formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of t-circle formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of telomeric circle formation" EXACT [GOC:TermGenie]
synonym: "downregulation of t-circle formation" EXACT [GOC:TermGenie]
synonym: "downregulation of telomeric circle formation" EXACT [GOC:TermGenie]
synonym: "inhibition of t-circle formation" NARROW [GOC:TermGenie]
synonym: "inhibition of telomeric circle formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of telomeric circle formation" EXACT [GOC:TermGenie]
is_a: GO:0032205 ! negative regulation of telomere maintenance
is_a: GO:1904429 ! regulation of t-circle formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0090656 ! t-circle formation
relationship: negatively_regulates GO:0090656 ! t-circle formation
created_by: nc
creation_date: 2015-07-03T15:15:52Z

[Term]
id: GO:1904431
name: positive regulation of t-circle formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of t-circle formation." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284]
synonym: "activation of t-circle formation" NARROW [GOC:TermGenie]
synonym: "activation of telomeric circle formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of telomeric circle formation" EXACT [GOC:TermGenie]
synonym: "up regulation of t-circle formation" EXACT [GOC:TermGenie]
synonym: "up regulation of telomeric circle formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of t-circle formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of telomeric circle formation" EXACT [GOC:TermGenie]
synonym: "upregulation of t-circle formation" EXACT [GOC:TermGenie]
synonym: "upregulation of telomeric circle formation" EXACT [GOC:TermGenie]
is_a: GO:0032206 ! positive regulation of telomere maintenance
is_a: GO:1904429 ! regulation of t-circle formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0090656 ! t-circle formation
relationship: positively_regulates GO:0090656 ! t-circle formation
created_by: nc
creation_date: 2015-07-03T15:15:58Z

[Term]
id: GO:1904432
name: regulation of ferrous iron binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ferrous iron binding." [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247]
is_a: GO:0051098 ! regulation of binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008198 ! ferrous iron binding
relationship: regulates GO:0008198 ! ferrous iron binding
created_by: kom
creation_date: 2015-07-06T13:46:30Z

[Term]
id: GO:1904433
name: negative regulation of ferrous iron binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ferrous iron binding." [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247]
synonym: "down regulation of ferrous iron binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of ferrous iron binding" EXACT [GOC:TermGenie]
synonym: "downregulation of ferrous iron binding" EXACT [GOC:TermGenie]
synonym: "inhibition of ferrous iron binding" NARROW [GOC:TermGenie]
is_a: GO:0051100 ! negative regulation of binding
is_a: GO:1904432 ! regulation of ferrous iron binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008198 ! ferrous iron binding
relationship: negatively_regulates GO:0008198 ! ferrous iron binding
created_by: kom
creation_date: 2015-07-06T13:46:36Z

[Term]
id: GO:1904434
name: positive regulation of ferrous iron binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ferrous iron binding." [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247]
synonym: "activation of ferrous iron binding" NARROW [GOC:TermGenie]
synonym: "up regulation of ferrous iron binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of ferrous iron binding" EXACT [GOC:TermGenie]
synonym: "upregulation of ferrous iron binding" EXACT [GOC:TermGenie]
is_a: GO:0051099 ! positive regulation of binding
is_a: GO:1904432 ! regulation of ferrous iron binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008198 ! ferrous iron binding
relationship: positively_regulates GO:0008198 ! ferrous iron binding
created_by: kom
creation_date: 2015-07-06T13:46:42Z

[Term]
id: GO:1904435
name: regulation of transferrin receptor binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transferrin receptor binding." [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247]
is_a: GO:1900120 ! regulation of receptor binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990459 ! transferrin receptor binding
relationship: regulates GO:1990459 ! transferrin receptor binding
created_by: kom
creation_date: 2015-07-06T13:49:01Z

[Term]
id: GO:1904436
name: negative regulation of transferrin receptor binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of transferrin receptor binding." [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247]
synonym: "down regulation of transferrin receptor binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of transferrin receptor binding" EXACT [GOC:TermGenie]
synonym: "downregulation of transferrin receptor binding" EXACT [GOC:TermGenie]
synonym: "inhibition of transferrin receptor binding" NARROW [GOC:TermGenie]
is_a: GO:1900121 ! negative regulation of receptor binding
is_a: GO:1904435 ! regulation of transferrin receptor binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990459 ! transferrin receptor binding
relationship: negatively_regulates GO:1990459 ! transferrin receptor binding
created_by: kom
creation_date: 2015-07-06T13:49:07Z

[Term]
id: GO:1904437
name: positive regulation of transferrin receptor binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transferrin receptor binding." [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247]
synonym: "activation of transferrin receptor binding" NARROW [GOC:TermGenie]
synonym: "up regulation of transferrin receptor binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of transferrin receptor binding" EXACT [GOC:TermGenie]
synonym: "upregulation of transferrin receptor binding" EXACT [GOC:TermGenie]
is_a: GO:1900122 ! positive regulation of receptor binding
is_a: GO:1904435 ! regulation of transferrin receptor binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990459 ! transferrin receptor binding
relationship: positively_regulates GO:1990459 ! transferrin receptor binding
created_by: kom
creation_date: 2015-07-06T13:49:13Z

[Term]
id: GO:1904438
name: regulation of ferrous iron import across plasma membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ferrous iron import across plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247]
is_a: GO:0034759 ! regulation of iron ion transmembrane transport
is_a: GO:1903989 ! regulation of ferrous iron import into cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0098707 ! ferrous iron import across plasma membrane
relationship: regulates GO:0098707 ! ferrous iron import across plasma membrane
created_by: kom
creation_date: 2015-07-06T13:49:52Z

[Term]
id: GO:1904439
name: negative regulation of ferrous iron import across plasma membrane
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ferrous iron import across plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247]
synonym: "down regulation of ferrous iron import across plasma membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of ferrous iron import across plasma membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of ferrous iron import across plasma membrane" EXACT [GOC:TermGenie]
synonym: "inhibition of ferrous iron import across plasma membrane" NARROW [GOC:TermGenie]
is_a: GO:0034760 ! negative regulation of iron ion transmembrane transport
is_a: GO:1903990 ! negative regulation of ferrous iron import into cell
is_a: GO:1904438 ! regulation of ferrous iron import across plasma membrane
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0098707 ! ferrous iron import across plasma membrane
relationship: negatively_regulates GO:0098707 ! ferrous iron import across plasma membrane
created_by: kom
creation_date: 2015-07-06T13:49:58Z

[Term]
id: GO:1904440
name: positive regulation of ferrous iron import across plasma membrane
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ferrous iron import across plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247]
synonym: "activation of ferrous iron import across plasma membrane" NARROW [GOC:TermGenie]
synonym: "up regulation of ferrous iron import across plasma membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of ferrous iron import across plasma membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of ferrous iron import across plasma membrane" EXACT [GOC:TermGenie]
is_a: GO:0034761 ! positive regulation of iron ion transmembrane transport
is_a: GO:1903991 ! positive regulation of ferrous iron import into cell
is_a: GO:1904438 ! regulation of ferrous iron import across plasma membrane
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0098707 ! ferrous iron import across plasma membrane
relationship: positively_regulates GO:0098707 ! ferrous iron import across plasma membrane
created_by: kom
creation_date: 2015-07-06T13:50:04Z

[Term]
id: GO:1904441
name: regulation of thyroid gland epithelial cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of thyroid gland epithelial cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:17646383]
synonym: "regulation of Hurthle cell proliferation" NARROW [GOC:TermGenie]
synonym: "regulation of thyroid follicular cell proliferation" NARROW [GOC:TermGenie]
is_a: GO:0050678 ! regulation of epithelial cell proliferation
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990789 ! thyroid gland epithelial cell proliferation
relationship: regulates GO:1990789 ! thyroid gland epithelial cell proliferation
created_by: sl
creation_date: 2015-07-06T15:41:09Z

[Term]
id: GO:1904442
name: negative regulation of thyroid gland epithelial cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of thyroid gland epithelial cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:17646383]
synonym: "down regulation of Hurthle cell proliferation" NARROW [GOC:TermGenie]
synonym: "down regulation of thyroid follicular cell proliferation" NARROW [GOC:TermGenie]
synonym: "down regulation of thyroid gland epithelial cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of Hurthle cell proliferation" NARROW [GOC:TermGenie]
synonym: "down-regulation of thyroid follicular cell proliferation" NARROW [GOC:TermGenie]
synonym: "down-regulation of thyroid gland epithelial cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of Hurthle cell proliferation" NARROW [GOC:TermGenie]
synonym: "downregulation of thyroid follicular cell proliferation" NARROW [GOC:TermGenie]
synonym: "downregulation of thyroid gland epithelial cell proliferation" EXACT [GOC:TermGenie]
synonym: "inhibition of Hurthle cell proliferation" NARROW [GOC:TermGenie]
synonym: "inhibition of thyroid follicular cell proliferation" NARROW [GOC:TermGenie]
synonym: "inhibition of thyroid gland epithelial cell proliferation" NARROW [GOC:TermGenie]
synonym: "negative regulation of Hurthle cell proliferation" NARROW [GOC:TermGenie]
synonym: "negative regulation of thyroid follicular cell proliferation" NARROW [GOC:TermGenie]
is_a: GO:0050680 ! negative regulation of epithelial cell proliferation
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1904441 ! regulation of thyroid gland epithelial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990789 ! thyroid gland epithelial cell proliferation
relationship: negatively_regulates GO:1990789 ! thyroid gland epithelial cell proliferation
created_by: sl
creation_date: 2015-07-06T15:41:15Z

[Term]
id: GO:1904443
name: positive regulation of thyroid gland epithelial cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of thyroid gland epithelial cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:17646383]
synonym: "activation of Hurthle cell proliferation" NARROW [GOC:TermGenie]
synonym: "activation of thyroid follicular cell proliferation" NARROW [GOC:TermGenie]
synonym: "activation of thyroid gland epithelial cell proliferation" NARROW [GOC:TermGenie]
synonym: "positive regulation of Hurthle cell proliferation" NARROW [GOC:TermGenie]
synonym: "positive regulation of thyroid follicular cell proliferation" NARROW [GOC:TermGenie]
synonym: "up regulation of Hurthle cell proliferation" NARROW [GOC:TermGenie]
synonym: "up regulation of thyroid follicular cell proliferation" NARROW [GOC:TermGenie]
synonym: "up regulation of thyroid gland epithelial cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of Hurthle cell proliferation" NARROW [GOC:TermGenie]
synonym: "up-regulation of thyroid follicular cell proliferation" NARROW [GOC:TermGenie]
synonym: "up-regulation of thyroid gland epithelial cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of Hurthle cell proliferation" NARROW [GOC:TermGenie]
synonym: "upregulation of thyroid follicular cell proliferation" NARROW [GOC:TermGenie]
synonym: "upregulation of thyroid gland epithelial cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0050679 ! positive regulation of epithelial cell proliferation
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1904441 ! regulation of thyroid gland epithelial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990789 ! thyroid gland epithelial cell proliferation
relationship: positively_regulates GO:1990789 ! thyroid gland epithelial cell proliferation
created_by: sl
creation_date: 2015-07-06T15:41:21Z

[Term]
id: GO:1904444
name: regulation of establishment of Sertoli cell barrier
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of establishment of Sertoli cell barrier." [GO_REF:0000058, GOC:TermGenie, PMID:18057314]
synonym: "regulation of establishment of blood-testis barrier" EXACT [GOC:TermGenie]
synonym: "regulation of establishment of BTB" EXACT [GOC:TermGenie]
synonym: "regulation of establishment of SCB" EXACT [GOC:TermGenie]
is_a: GO:0030856 ! regulation of epithelial cell differentiation
is_a: GO:0060284 ! regulation of cell development
is_a: GO:2000018 ! regulation of male gonad development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097368 ! establishment of Sertoli cell barrier
relationship: regulates GO:0097368 ! establishment of Sertoli cell barrier
created_by: sl
creation_date: 2015-07-06T16:00:41Z

[Term]
id: GO:1904445
name: negative regulation of establishment of Sertoli cell barrier
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of Sertoli cell barrier." [GO_REF:0000058, GOC:TermGenie, PMID:18057314]
synonym: "down regulation of establishment of blood-testis barrier" EXACT [GOC:TermGenie]
synonym: "down regulation of establishment of BTB" EXACT [GOC:TermGenie]
synonym: "down regulation of establishment of SCB" EXACT [GOC:TermGenie]
synonym: "down regulation of establishment of Sertoli cell barrier" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of blood-testis barrier" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of BTB" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of SCB" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of Sertoli cell barrier" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of blood-testis barrier" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of BTB" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of SCB" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of Sertoli cell barrier" EXACT [GOC:TermGenie]
synonym: "inhibition of establishment of blood-testis barrier" NARROW [GOC:TermGenie]
synonym: "inhibition of establishment of BTB" NARROW [GOC:TermGenie]
synonym: "inhibition of establishment of SCB" NARROW [GOC:TermGenie]
synonym: "inhibition of establishment of Sertoli cell barrier" NARROW [GOC:TermGenie]
synonym: "negative regulation of establishment of blood-testis barrier" EXACT [GOC:TermGenie]
synonym: "negative regulation of establishment of BTB" EXACT [GOC:TermGenie]
synonym: "negative regulation of establishment of SCB" EXACT [GOC:TermGenie]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0030857 ! negative regulation of epithelial cell differentiation
is_a: GO:1904444 ! regulation of establishment of Sertoli cell barrier
is_a: GO:2000019 ! negative regulation of male gonad development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097368 ! establishment of Sertoli cell barrier
relationship: negatively_regulates GO:0097368 ! establishment of Sertoli cell barrier
created_by: sl
creation_date: 2015-07-06T16:00:48Z

[Term]
id: GO:1904446
name: positive regulation of establishment of Sertoli cell barrier
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment of Sertoli cell barrier." [GO_REF:0000058, GOC:TermGenie, PMID:18057314]
synonym: "activation of establishment of blood-testis barrier" NARROW [GOC:TermGenie]
synonym: "activation of establishment of BTB" NARROW [GOC:TermGenie]
synonym: "activation of establishment of SCB" NARROW [GOC:TermGenie]
synonym: "activation of establishment of Sertoli cell barrier" NARROW [GOC:TermGenie]
synonym: "positive regulation of establishment of blood-testis barrier" EXACT [GOC:TermGenie]
synonym: "positive regulation of establishment of BTB" EXACT [GOC:TermGenie]
synonym: "positive regulation of establishment of SCB" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of blood-testis barrier" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of BTB" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of SCB" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of Sertoli cell barrier" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of blood-testis barrier" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of BTB" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of SCB" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of Sertoli cell barrier" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of blood-testis barrier" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of BTB" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of SCB" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of Sertoli cell barrier" EXACT [GOC:TermGenie]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0030858 ! positive regulation of epithelial cell differentiation
is_a: GO:1904444 ! regulation of establishment of Sertoli cell barrier
is_a: GO:2000020 ! positive regulation of male gonad development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097368 ! establishment of Sertoli cell barrier
relationship: positively_regulates GO:0097368 ! establishment of Sertoli cell barrier
created_by: sl
creation_date: 2015-07-06T16:00:54Z

[Term]
id: GO:1904447
name: folic acid import into cell
namespace: biological_process
def: "The directed movement of folic acid from outside of a cell, across the plasma membrane and into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [GO_REF:0000075, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:19762432]
synonym: "folate import into cell" EXACT [GOC:hal]
is_a: GO:0015884 ! folic acid transport
created_by: hal
creation_date: 2015-07-07T15:32:33Z

[Term]
id: GO:1904448
name: regulation of aspartate secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of aspartate secretion." [GO_REF:0000058, GOC:TermGenie, PMID:2342602]
is_a: GO:0051955 ! regulation of amino acid transport
is_a: GO:1903530 ! regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061528 ! aspartate secretion
relationship: regulates GO:0061528 ! aspartate secretion
created_by: sl
creation_date: 2015-07-07T20:56:57Z

[Term]
id: GO:1904449
name: negative regulation of aspartate secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of aspartate secretion." [GO_REF:0000058, GOC:TermGenie, PMID:2342602]
synonym: "down regulation of aspartate secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of aspartate secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of aspartate secretion" EXACT [GOC:TermGenie]
synonym: "inhibition of aspartate secretion" NARROW [GOC:TermGenie]
is_a: GO:0051956 ! negative regulation of amino acid transport
is_a: GO:1903531 ! negative regulation of secretion by cell
is_a: GO:1904448 ! regulation of aspartate secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061528 ! aspartate secretion
relationship: negatively_regulates GO:0061528 ! aspartate secretion
created_by: sl
creation_date: 2015-07-07T20:57:04Z

[Term]
id: GO:1904450
name: positive regulation of aspartate secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of aspartate secretion." [GO_REF:0000058, GOC:TermGenie, PMID:2342602]
synonym: "activation of aspartate secretion" NARROW [GOC:TermGenie]
synonym: "up regulation of aspartate secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of aspartate secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of aspartate secretion" EXACT [GOC:TermGenie]
is_a: GO:0051957 ! positive regulation of amino acid transport
is_a: GO:1903532 ! positive regulation of secretion by cell
is_a: GO:1904448 ! regulation of aspartate secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061528 ! aspartate secretion
relationship: positively_regulates GO:0061528 ! aspartate secretion
created_by: sl
creation_date: 2015-07-07T20:57:10Z

[Term]
id: GO:1904451
name: regulation of hydrogen:potassium-exchanging ATPase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hydrogen:potassium-exchanging ATPase activity." [GO_REF:0000059, GOC:TermGenie, PMID:11897793]
synonym: "regulation of (K+ + H+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "regulation of ATP phosphohydrolase (H+/K+-exchanging)" EXACT [GOC:TermGenie]
synonym: "regulation of gastric H(+)/K(+) ATPase activity" NARROW [GOC:TermGenie]
synonym: "regulation of gastric H+/K+ ATPase" NARROW [GOC:TermGenie]
synonym: "regulation of H(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "regulation of H(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "regulation of H+-K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "regulation of H+/K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "regulation of H+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "regulation of H,K-ATPase activity" EXACT [GOC:TermGenie]
synonym: "regulation of hydrogen/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "regulation of hydrogen:potassium exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "regulation of proton pump activity" BROAD [GOC:TermGenie]
is_a: GO:0010155 ! regulation of proton transport
is_a: GO:0043462 ! regulation of ATPase activity
is_a: GO:1901016 ! regulation of potassium ion transmembrane transporter activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008900 ! hydrogen:potassium-exchanging ATPase activity
relationship: regulates GO:0008900 ! hydrogen:potassium-exchanging ATPase activity
created_by: sl
creation_date: 2015-07-08T23:00:03Z

[Term]
id: GO:1904452
name: negative regulation of hydrogen:potassium-exchanging ATPase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen:potassium-exchanging ATPase activity." [GO_REF:0000059, GOC:TermGenie, PMID:11897793]
synonym: "down regulation of (K+ + H+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of ATP phosphohydrolase (H+/K+-exchanging)" EXACT [GOC:TermGenie]
synonym: "down regulation of gastric H(+)/K(+) ATPase activity" NARROW [GOC:TermGenie]
synonym: "down regulation of gastric H+/K+ ATPase" NARROW [GOC:TermGenie]
synonym: "down regulation of H(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of H(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of H+-K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of H+/K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of H+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of H,K-ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of hydrogen/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of hydrogen:potassium exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of hydrogen:potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of (K+ + H+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of ATP phosphohydrolase (H+/K+-exchanging)" EXACT [GOC:TermGenie]
synonym: "down-regulation of gastric H(+)/K(+) ATPase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of gastric H+/K+ ATPase" NARROW [GOC:TermGenie]
synonym: "down-regulation of H(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of H(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of H+-K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of H+/K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of H+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of H,K-ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of hydrogen/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of hydrogen:potassium exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of hydrogen:potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of (K+ + H+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of ATP phosphohydrolase (H+/K+-exchanging)" EXACT [GOC:TermGenie]
synonym: "downregulation of gastric H(+)/K(+) ATPase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of gastric H+/K+ ATPase" NARROW [GOC:TermGenie]
synonym: "downregulation of H(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of H(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of H+-K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of H+/K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of H+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of H,K-ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of hydrogen/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of hydrogen:potassium exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of hydrogen:potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of (K+ + H+)-ATPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of ATP phosphohydrolase (H+/K+-exchanging)" NARROW [GOC:TermGenie]
synonym: "inhibition of gastric H(+)/K(+) ATPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of gastric H+/K+ ATPase" NARROW [GOC:TermGenie]
synonym: "inhibition of H(+)/K(+)-ATPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of H(+)/K(+)-exchanging ATPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of H+-K+-ATPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of H+/K+-ATPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of H+/K+-exchanging ATPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of H,K-ATPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of hydrogen/potassium-exchanging ATPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of hydrogen:potassium exchanging ATPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of hydrogen:potassium-exchanging ATPase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of (K+ + H+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of ATP phosphohydrolase (H+/K+-exchanging)" EXACT [GOC:TermGenie]
synonym: "negative regulation of gastric H(+)/K(+) ATPase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of gastric H+/K+ ATPase" NARROW [GOC:TermGenie]
synonym: "negative regulation of H(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of H(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of H+-K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of H+/K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of H+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of H,K-ATPase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of hydrogen/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of hydrogen:potassium exchanging ATPase activity" EXACT [GOC:TermGenie]
is_a: GO:0032780 ! negative regulation of ATPase activity
is_a: GO:1901017 ! negative regulation of potassium ion transmembrane transporter activity
is_a: GO:1904451 ! regulation of hydrogen:potassium-exchanging ATPase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008900 ! hydrogen:potassium-exchanging ATPase activity
relationship: negatively_regulates GO:0008900 ! hydrogen:potassium-exchanging ATPase activity
created_by: sl
creation_date: 2015-07-08T23:00:09Z

[Term]
id: GO:1904453
name: positive regulation of hydrogen:potassium-exchanging ATPase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hydrogen:potassium-exchanging ATPase activity." [GO_REF:0000059, GOC:TermGenie, PMID:11897793]
synonym: "activation of (K+ + H+)-ATPase activity" NARROW [GOC:TermGenie]
synonym: "activation of ATP phosphohydrolase (H+/K+-exchanging)" NARROW [GOC:TermGenie]
synonym: "activation of gastric H(+)/K(+) ATPase activity" NARROW [GOC:TermGenie]
synonym: "activation of gastric H+/K+ ATPase" NARROW [GOC:TermGenie]
synonym: "activation of H(+)/K(+)-ATPase activity" NARROW [GOC:TermGenie]
synonym: "activation of H(+)/K(+)-exchanging ATPase activity" NARROW [GOC:TermGenie]
synonym: "activation of H+-K+-ATPase activity" NARROW [GOC:TermGenie]
synonym: "activation of H+/K+-ATPase activity" NARROW [GOC:TermGenie]
synonym: "activation of H+/K+-exchanging ATPase activity" NARROW [GOC:TermGenie]
synonym: "activation of H,K-ATPase activity" NARROW [GOC:TermGenie]
synonym: "activation of hydrogen/potassium-exchanging ATPase activity" NARROW [GOC:TermGenie]
synonym: "activation of hydrogen:potassium exchanging ATPase activity" NARROW [GOC:TermGenie]
synonym: "activation of hydrogen:potassium-exchanging ATPase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of (K+ + H+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of ATP phosphohydrolase (H+/K+-exchanging)" EXACT [GOC:TermGenie]
synonym: "positive regulation of gastric H(+)/K(+) ATPase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of gastric H+/K+ ATPase" NARROW [GOC:TermGenie]
synonym: "positive regulation of H(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of H(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of H+-K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of H+/K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of H+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of H,K-ATPase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of hydrogen/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of hydrogen:potassium exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of (K+ + H+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of ATP phosphohydrolase (H+/K+-exchanging)" EXACT [GOC:TermGenie]
synonym: "up regulation of gastric H(+)/K(+) ATPase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of gastric H+/K+ ATPase" NARROW [GOC:TermGenie]
synonym: "up regulation of H(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of H(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of H+-K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of H+/K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of H+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of H,K-ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of hydrogen/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of hydrogen:potassium exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of hydrogen:potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of (K+ + H+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of ATP phosphohydrolase (H+/K+-exchanging)" EXACT [GOC:TermGenie]
synonym: "up-regulation of gastric H(+)/K(+) ATPase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of gastric H+/K+ ATPase" NARROW [GOC:TermGenie]
synonym: "up-regulation of H(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of H(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of H+-K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of H+/K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of H+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of H,K-ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of hydrogen/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of hydrogen:potassium exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of hydrogen:potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of (K+ + H+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of ATP phosphohydrolase (H+/K+-exchanging)" EXACT [GOC:TermGenie]
synonym: "upregulation of gastric H(+)/K(+) ATPase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of gastric H+/K+ ATPase" NARROW [GOC:TermGenie]
synonym: "upregulation of H(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of H(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of H+-K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of H+/K+-ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of H+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of H,K-ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of hydrogen/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of hydrogen:potassium exchanging ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of hydrogen:potassium-exchanging ATPase activity" EXACT [GOC:TermGenie]
is_a: GO:0032781 ! positive regulation of ATPase activity
is_a: GO:1901018 ! positive regulation of potassium ion transmembrane transporter activity
is_a: GO:1904451 ! regulation of hydrogen:potassium-exchanging ATPase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008900 ! hydrogen:potassium-exchanging ATPase activity
relationship: positively_regulates GO:0008900 ! hydrogen:potassium-exchanging ATPase activity
created_by: sl
creation_date: 2015-07-08T23:00:15Z

[Term]
id: GO:1904454
name: ubiquitin-specific protease activity involved in positive regulation of ERAD pathway
namespace: molecular_function
def: "Any ubiquitin-specific protease activity that is involved in positive regulation of ERAD pathway." [GO_REF:0000061, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24424410]
synonym: "deubiquitinase activity involved in activation of endoplasmic reticulum-associated degradation" NARROW [GOC:TermGenie]
synonym: "deubiquitinase activity involved in activation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinase activity involved in activation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinase activity involved in activation of ERAD pathway" NARROW [GOC:TermGenie]
synonym: "deubiquitinase activity involved in positive regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "deubiquitinase activity involved in positive regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinase activity involved in positive regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinase activity involved in positive regulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "deubiquitinase activity involved in up regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "deubiquitinase activity involved in up regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinase activity involved in up regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinase activity involved in up regulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "deubiquitinase activity involved in up-regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "deubiquitinase activity involved in up-regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinase activity involved in up-regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinase activity involved in up-regulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "deubiquitinase activity involved in upregulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "deubiquitinase activity involved in upregulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinase activity involved in upregulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinase activity involved in upregulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "deubiquitinase involved in activation of endoplasmic reticulum-associated degradation" NARROW [GOC:TermGenie]
synonym: "deubiquitinase involved in activation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinase involved in activation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinase involved in activation of ERAD pathway" NARROW [GOC:TermGenie]
synonym: "deubiquitinase involved in positive regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "deubiquitinase involved in positive regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinase involved in positive regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinase involved in positive regulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "deubiquitinase involved in up regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "deubiquitinase involved in up regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinase involved in up regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinase involved in up regulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "deubiquitinase involved in up-regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "deubiquitinase involved in up-regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinase involved in up-regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinase involved in up-regulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "deubiquitinase involved in upregulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "deubiquitinase involved in upregulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinase involved in upregulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinase involved in upregulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in activation of endoplasmic reticulum-associated degradation" NARROW [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in activation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in activation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in activation of ERAD pathway" NARROW [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in positive regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in positive regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in positive regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in positive regulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in up regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in up regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in up regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in up regulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in up-regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in up-regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in up-regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in up-regulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in upregulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in upregulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in upregulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in upregulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "deubiquitylase involved in activation of endoplasmic reticulum-associated degradation" NARROW [GOC:TermGenie]
synonym: "deubiquitylase involved in activation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitylase involved in activation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitylase involved in activation of ERAD pathway" NARROW [GOC:TermGenie]
synonym: "deubiquitylase involved in positive regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "deubiquitylase involved in positive regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitylase involved in positive regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitylase involved in positive regulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "deubiquitylase involved in up regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "deubiquitylase involved in up regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitylase involved in up regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitylase involved in up regulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "deubiquitylase involved in up-regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "deubiquitylase involved in up-regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitylase involved in up-regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitylase involved in up-regulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "deubiquitylase involved in upregulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "deubiquitylase involved in upregulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitylase involved in upregulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitylase involved in upregulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "DUB activity involved in positive regulation of ERAD" EXACT [PMID:24424410]
synonym: "ubiquitin C-terminal hydrolase activity involved in activation of endoplasmic reticulum-associated degradation" NARROW [GOC:TermGenie]
synonym: "ubiquitin C-terminal hydrolase activity involved in activation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin C-terminal hydrolase activity involved in activation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin C-terminal hydrolase activity involved in activation of ERAD pathway" NARROW [GOC:TermGenie]
synonym: "ubiquitin C-terminal hydrolase activity involved in positive regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "ubiquitin C-terminal hydrolase activity involved in positive regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin C-terminal hydrolase activity involved in positive regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin C-terminal hydrolase activity involved in positive regulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "ubiquitin C-terminal hydrolase activity involved in up regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "ubiquitin C-terminal hydrolase activity involved in up regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin C-terminal hydrolase activity involved in up regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin C-terminal hydrolase activity involved in up regulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "ubiquitin C-terminal hydrolase activity involved in up-regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "ubiquitin C-terminal hydrolase activity involved in up-regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin C-terminal hydrolase activity involved in up-regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin C-terminal hydrolase activity involved in up-regulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "ubiquitin C-terminal hydrolase activity involved in upregulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "ubiquitin C-terminal hydrolase activity involved in upregulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin C-terminal hydrolase activity involved in upregulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin C-terminal hydrolase activity involved in upregulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in activation of endoplasmic reticulum-associated degradation" NARROW [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in activation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in activation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in activation of ERAD pathway" NARROW [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in positive regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in positive regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in positive regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in positive regulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in up regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in up regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in up regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in up regulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in up-regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in up-regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in up-regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in up-regulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in upregulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in upregulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in upregulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in upregulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "ubiquitin-specific protease activity involved in activation of endoplasmic reticulum-associated degradation" NARROW [GOC:TermGenie]
synonym: "ubiquitin-specific protease activity involved in activation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin-specific protease activity involved in activation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin-specific protease activity involved in activation of ERAD pathway" NARROW [GOC:TermGenie]
synonym: "ubiquitin-specific protease activity involved in positive regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "ubiquitin-specific protease activity involved in positive regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin-specific protease activity involved in positive regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin-specific protease activity involved in up regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "ubiquitin-specific protease activity involved in up regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin-specific protease activity involved in up regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin-specific protease activity involved in up regulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "ubiquitin-specific protease activity involved in up-regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "ubiquitin-specific protease activity involved in up-regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin-specific protease activity involved in up-regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin-specific protease activity involved in up-regulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "ubiquitin-specific protease activity involved in upregulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "ubiquitin-specific protease activity involved in upregulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin-specific protease activity involved in upregulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin-specific protease activity involved in upregulation of ERAD pathway" EXACT [GOC:TermGenie]
is_a: GO:0101005 ! ubiquitinyl hydrolase activity
intersection_of: GO:0101005 ! ubiquitinyl hydrolase activity
intersection_of: part_of GO:1904294 ! positive regulation of ERAD pathway
relationship: part_of GO:1904294 ! positive regulation of ERAD pathway
created_by: bf
creation_date: 2015-07-09T10:24:37Z

[Term]
id: GO:1904455
name: ubiquitin-specific protease activity involved in negative regulation of ERAD pathway
namespace: molecular_function
def: "Any ubiquitin-specific protease activity that is involved in negative regulation of ERAD pathway." [GO_REF:0000061, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22590560]
synonym: "deubiquitinase activity involved in down regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "deubiquitinase activity involved in down regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinase activity involved in down regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinase activity involved in down regulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "deubiquitinase activity involved in down-regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "deubiquitinase activity involved in down-regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinase activity involved in down-regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinase activity involved in down-regulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "deubiquitinase activity involved in downregulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "deubiquitinase activity involved in downregulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinase activity involved in downregulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinase activity involved in downregulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "deubiquitinase activity involved in inhibition of endoplasmic reticulum-associated degradation" NARROW [GOC:TermGenie]
synonym: "deubiquitinase activity involved in inhibition of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinase activity involved in inhibition of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinase activity involved in inhibition of ERAD pathway" NARROW [GOC:TermGenie]
synonym: "deubiquitinase activity involved in negative regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "deubiquitinase activity involved in negative regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinase activity involved in negative regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinase activity involved in negative regulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "deubiquitinase involved in down regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "deubiquitinase involved in down regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinase involved in down regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinase involved in down regulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "deubiquitinase involved in down-regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "deubiquitinase involved in down-regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinase involved in down-regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinase involved in down-regulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "deubiquitinase involved in downregulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "deubiquitinase involved in downregulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinase involved in downregulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinase involved in downregulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "deubiquitinase involved in inhibition of endoplasmic reticulum-associated degradation" NARROW [GOC:TermGenie]
synonym: "deubiquitinase involved in inhibition of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinase involved in inhibition of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinase involved in inhibition of ERAD pathway" NARROW [GOC:TermGenie]
synonym: "deubiquitinase involved in negative regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "deubiquitinase involved in negative regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinase involved in negative regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinase involved in negative regulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in down regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in down regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in down regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in down regulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in down-regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in down-regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in down-regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in down-regulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in downregulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in downregulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in downregulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in downregulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in inhibition of endoplasmic reticulum-associated degradation" NARROW [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in inhibition of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in inhibition of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in inhibition of ERAD pathway" NARROW [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in negative regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in negative regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in negative regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitinating enzyme involved in negative regulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "deubiquitylase involved in down regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "deubiquitylase involved in down regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitylase involved in down regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitylase involved in down regulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "deubiquitylase involved in down-regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "deubiquitylase involved in down-regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitylase involved in down-regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitylase involved in down-regulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "deubiquitylase involved in downregulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "deubiquitylase involved in downregulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitylase involved in downregulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitylase involved in downregulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "deubiquitylase involved in inhibition of endoplasmic reticulum-associated degradation" NARROW [GOC:TermGenie]
synonym: "deubiquitylase involved in inhibition of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitylase involved in inhibition of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitylase involved in inhibition of ERAD pathway" NARROW [GOC:TermGenie]
synonym: "deubiquitylase involved in negative regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "deubiquitylase involved in negative regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitylase involved in negative regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "deubiquitylase involved in negative regulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "DUB activity involved in negative regulation of ERAD" EXACT [GOC:bf]
synonym: "ubiquitin C-terminal hydrolase activity involved in down regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "ubiquitin C-terminal hydrolase activity involved in down regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin C-terminal hydrolase activity involved in down regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin C-terminal hydrolase activity involved in down regulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "ubiquitin C-terminal hydrolase activity involved in down-regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "ubiquitin C-terminal hydrolase activity involved in down-regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin C-terminal hydrolase activity involved in down-regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin C-terminal hydrolase activity involved in down-regulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "ubiquitin C-terminal hydrolase activity involved in downregulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "ubiquitin C-terminal hydrolase activity involved in downregulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin C-terminal hydrolase activity involved in downregulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin C-terminal hydrolase activity involved in downregulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "ubiquitin C-terminal hydrolase activity involved in inhibition of endoplasmic reticulum-associated degradation" NARROW [GOC:TermGenie]
synonym: "ubiquitin C-terminal hydrolase activity involved in inhibition of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin C-terminal hydrolase activity involved in inhibition of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin C-terminal hydrolase activity involved in inhibition of ERAD pathway" NARROW [GOC:TermGenie]
synonym: "ubiquitin C-terminal hydrolase activity involved in negative regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "ubiquitin C-terminal hydrolase activity involved in negative regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin C-terminal hydrolase activity involved in negative regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin C-terminal hydrolase activity involved in negative regulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in down regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in down regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in down regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in down regulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in down-regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in down-regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in down-regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in down-regulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in downregulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in downregulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in downregulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in downregulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in inhibition of endoplasmic reticulum-associated degradation" NARROW [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in inhibition of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in inhibition of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in inhibition of ERAD pathway" NARROW [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in negative regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in negative regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in negative regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin hydrolase activity involved in negative regulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "ubiquitin-specific protease activity involved in down regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "ubiquitin-specific protease activity involved in down regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin-specific protease activity involved in down regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin-specific protease activity involved in down regulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "ubiquitin-specific protease activity involved in down-regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "ubiquitin-specific protease activity involved in down-regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin-specific protease activity involved in down-regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin-specific protease activity involved in down-regulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "ubiquitin-specific protease activity involved in downregulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "ubiquitin-specific protease activity involved in downregulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin-specific protease activity involved in downregulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin-specific protease activity involved in downregulation of ERAD pathway" EXACT [GOC:TermGenie]
synonym: "ubiquitin-specific protease activity involved in inhibition of endoplasmic reticulum-associated degradation" NARROW [GOC:TermGenie]
synonym: "ubiquitin-specific protease activity involved in inhibition of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin-specific protease activity involved in inhibition of ER-associated degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin-specific protease activity involved in inhibition of ERAD pathway" NARROW [GOC:TermGenie]
synonym: "ubiquitin-specific protease activity involved in negative regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie]
synonym: "ubiquitin-specific protease activity involved in negative regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie]
synonym: "ubiquitin-specific protease activity involved in negative regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie]
is_a: GO:0101005 ! ubiquitinyl hydrolase activity
intersection_of: GO:0101005 ! ubiquitinyl hydrolase activity
intersection_of: part_of GO:1904293 ! negative regulation of ERAD pathway
relationship: part_of GO:1904293 ! negative regulation of ERAD pathway
created_by: bf
creation_date: 2015-07-09T10:49:53Z

[Term]
id: GO:1904456
name: negative regulation of neuronal action potential
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuronal action potential." [GO_REF:0000058, GOC:TermGenie, PMID:25126967]
synonym: "down regulation of generation of action potential" RELATED [GOC:TermGenie]
synonym: "down regulation of neuronal action potential" EXACT [GOC:TermGenie]
synonym: "down-regulation of generation of action potential" RELATED [GOC:TermGenie]
synonym: "down-regulation of neuronal action potential" EXACT [GOC:TermGenie]
synonym: "downregulation of generation of action potential" RELATED [GOC:TermGenie]
synonym: "downregulation of neuronal action potential" EXACT [GOC:TermGenie]
synonym: "inhibition of generation of action potential" RELATED [GOC:TermGenie]
synonym: "inhibition of neuronal action potential" NARROW [GOC:TermGenie]
synonym: "negative regulation of generation of action potential" RELATED [GOC:TermGenie]
is_a: GO:0045759 ! negative regulation of action potential
is_a: GO:0051970 ! negative regulation of transmission of nerve impulse
is_a: GO:0098908 ! regulation of neuronal action potential
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019228 ! neuronal action potential
relationship: negatively_regulates GO:0019228 ! neuronal action potential
created_by: sl
creation_date: 2015-07-09T18:02:40Z

[Term]
id: GO:1904457
name: positive regulation of neuronal action potential
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neuronal action potential." [GO_REF:0000058, GOC:TermGenie, PMID:25126967]
synonym: "activation of generation of action potential" RELATED [GOC:TermGenie]
synonym: "activation of neuronal action potential" NARROW [GOC:TermGenie]
synonym: "positive regulation of generation of action potential" RELATED [GOC:TermGenie]
synonym: "up regulation of generation of action potential" RELATED [GOC:TermGenie]
synonym: "up regulation of neuronal action potential" EXACT [GOC:TermGenie]
synonym: "up-regulation of generation of action potential" RELATED [GOC:TermGenie]
synonym: "up-regulation of neuronal action potential" EXACT [GOC:TermGenie]
synonym: "upregulation of generation of action potential" RELATED [GOC:TermGenie]
synonym: "upregulation of neuronal action potential" EXACT [GOC:TermGenie]
is_a: GO:0045760 ! positive regulation of action potential
is_a: GO:0051971 ! positive regulation of transmission of nerve impulse
is_a: GO:0098908 ! regulation of neuronal action potential
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0019228 ! neuronal action potential
relationship: positively_regulates GO:0019228 ! neuronal action potential
created_by: sl
creation_date: 2015-07-09T18:02:46Z

[Term]
id: GO:1904458
name: regulation of substance P secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of substance P secretion." [GO_REF:0000058, GOC:TermGenie, PMID:11278900]
is_a: GO:0090276 ! regulation of peptide hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990772 ! substance P secretion
relationship: regulates GO:1990772 ! substance P secretion
created_by: sl
creation_date: 2015-07-09T19:32:50Z

[Term]
id: GO:1904459
name: negative regulation of substance P secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of substance P secretion." [GO_REF:0000058, GOC:TermGenie, PMID:11278900]
synonym: "down regulation of substance P secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of substance P secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of substance P secretion" EXACT [GOC:TermGenie]
synonym: "inhibition of substance P secretion" NARROW [GOC:TermGenie]
is_a: GO:0090278 ! negative regulation of peptide hormone secretion
is_a: GO:1904458 ! regulation of substance P secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990772 ! substance P secretion
relationship: negatively_regulates GO:1990772 ! substance P secretion
created_by: sl
creation_date: 2015-07-09T19:32:57Z

[Term]
id: GO:1904460
name: positive regulation of substance P secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of substance P secretion." [GO_REF:0000058, GOC:TermGenie, PMID:11278900]
synonym: "activation of substance P secretion" NARROW [GOC:TermGenie]
synonym: "up regulation of substance P secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of substance P secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of substance P secretion" EXACT [GOC:TermGenie]
is_a: GO:0090277 ! positive regulation of peptide hormone secretion
is_a: GO:1904458 ! regulation of substance P secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990772 ! substance P secretion
relationship: positively_regulates GO:1990772 ! substance P secretion
created_by: sl
creation_date: 2015-07-09T19:33:03Z

[Term]
id: GO:1904461
name: ergosteryl 3-beta-D-glucoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ergosteryl 3-beta-D-glucoside." [GO_REF:0000068, GOC:TermGenie, PMID:26116408]
synonym: "ergosteryl 3-beta-D-glucoside metabolism" EXACT [GOC:TermGenie]
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:0016134 ! saponin metabolic process
is_a: GO:1901804 ! beta-glucoside metabolic process
created_by: mcc
creation_date: 2015-07-09T19:36:19Z

[Term]
id: GO:1904462
name: ergosteryl 3-beta-D-glucoside catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ergosteryl 3-beta-D-glucoside." [GO_REF:0000068, GOC:TermGenie, PMID:26116408]
synonym: "ergosteryl 3-beta-D-glucoside breakdown" EXACT [GOC:TermGenie]
synonym: "ergosteryl 3-beta-D-glucoside catabolism" EXACT [GOC:TermGenie]
synonym: "ergosteryl 3-beta-D-glucoside degradation" EXACT [GOC:TermGenie]
is_a: GO:0006706 ! steroid catabolic process
is_a: GO:0016136 ! saponin catabolic process
is_a: GO:1901805 ! beta-glucoside catabolic process
is_a: GO:1904461 ! ergosteryl 3-beta-D-glucoside metabolic process
created_by: mcc
creation_date: 2015-07-09T19:36:25Z

[Term]
id: GO:1904463
name: ergosteryl 3-beta-D-glucoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ergosteryl 3-beta-D-glucoside." [GO_REF:0000068, GOC:TermGenie, PMID:26116408]
synonym: "ergosteryl 3-beta-D-glucoside anabolism" EXACT [GOC:TermGenie]
synonym: "ergosteryl 3-beta-D-glucoside biosynthesis" EXACT [GOC:TermGenie]
synonym: "ergosteryl 3-beta-D-glucoside formation" EXACT [GOC:TermGenie]
synonym: "ergosteryl 3-beta-D-glucoside synthesis" EXACT [GOC:TermGenie]
is_a: GO:0006694 ! steroid biosynthetic process
is_a: GO:0016135 ! saponin biosynthetic process
is_a: GO:1901806 ! beta-glucoside biosynthetic process
is_a: GO:1904461 ! ergosteryl 3-beta-D-glucoside metabolic process
created_by: mcc
creation_date: 2015-07-09T19:36:31Z

[Term]
id: GO:1904464
name: regulation of matrix metallopeptidase secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of matrix metallopeptidase secretion." [GO_REF:0000058, GOC:TermGenie, PMID:8679543]
synonym: "regulation of matrix metalloproteinase secretion" NARROW [GOC:TermGenie]
synonym: "regulation of MMP secretion" EXACT [GOC:TermGenie]
is_a: GO:0050708 ! regulation of protein secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990773 ! matrix metallopeptidase secretion
relationship: regulates GO:1990773 ! matrix metallopeptidase secretion
created_by: sl
creation_date: 2015-07-09T19:46:17Z

[Term]
id: GO:1904465
name: negative regulation of matrix metallopeptidase secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of matrix metallopeptidase secretion." [GO_REF:0000058, GOC:TermGenie, PMID:8679543]
synonym: "down regulation of matrix metallopeptidase secretion" EXACT [GOC:TermGenie]
synonym: "down regulation of matrix metalloproteinase secretion" NARROW [GOC:TermGenie]
synonym: "down regulation of MMP secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of matrix metallopeptidase secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of matrix metalloproteinase secretion" NARROW [GOC:TermGenie]
synonym: "down-regulation of MMP secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of matrix metallopeptidase secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of matrix metalloproteinase secretion" NARROW [GOC:TermGenie]
synonym: "downregulation of MMP secretion" EXACT [GOC:TermGenie]
synonym: "inhibition of matrix metallopeptidase secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of matrix metalloproteinase secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of MMP secretion" NARROW [GOC:TermGenie]
synonym: "negative regulation of matrix metalloproteinase secretion" NARROW [GOC:TermGenie]
synonym: "negative regulation of MMP secretion" EXACT [GOC:TermGenie]
is_a: GO:0050709 ! negative regulation of protein secretion
is_a: GO:1904464 ! regulation of matrix metallopeptidase secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990773 ! matrix metallopeptidase secretion
relationship: negatively_regulates GO:1990773 ! matrix metallopeptidase secretion
created_by: sl
creation_date: 2015-07-09T19:46:24Z

[Term]
id: GO:1904466
name: positive regulation of matrix metallopeptidase secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of matrix metallopeptidase secretion." [GO_REF:0000058, GOC:TermGenie, PMID:8679543]
synonym: "activation of matrix metallopeptidase secretion" NARROW [GOC:TermGenie]
synonym: "activation of matrix metalloproteinase secretion" NARROW [GOC:TermGenie]
synonym: "activation of MMP secretion" NARROW [GOC:TermGenie]
synonym: "positive regulation of matrix metalloproteinase secretion" NARROW [GOC:TermGenie]
synonym: "positive regulation of MMP secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of matrix metallopeptidase secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of matrix metalloproteinase secretion" NARROW [GOC:TermGenie]
synonym: "up regulation of MMP secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of matrix metallopeptidase secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of matrix metalloproteinase secretion" NARROW [GOC:TermGenie]
synonym: "up-regulation of MMP secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of matrix metallopeptidase secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of matrix metalloproteinase secretion" NARROW [GOC:TermGenie]
synonym: "upregulation of MMP secretion" EXACT [GOC:TermGenie]
is_a: GO:0050714 ! positive regulation of protein secretion
is_a: GO:1904464 ! regulation of matrix metallopeptidase secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990773 ! matrix metallopeptidase secretion
relationship: positively_regulates GO:1990773 ! matrix metallopeptidase secretion
created_by: sl
creation_date: 2015-07-09T19:46:30Z

[Term]
id: GO:1904467
name: regulation of tumor necrosis factor secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tumor necrosis factor secretion." [GO_REF:0000058, GOC:TermGenie, PMID:15560120]
synonym: "regulation of cachectin secretion" EXACT [GOC:TermGenie]
synonym: "regulation of TNF secretion" EXACT [GOC:TermGenie]
synonym: "regulation of TNF superfamily, member 2 secretion" EXACT [GOC:TermGenie]
synonym: "regulation of TNF-alpha secretion" EXACT [GOC:TermGenie]
synonym: "regulation of Tnfa secretion" EXACT [GOC:TermGenie]
synonym: "regulation of tumor necrosis factor alpha secretion" EXACT [GOC:TermGenie]
synonym: "regulation of tumor necrosis factor ligand superfamily member 2 secretion" EXACT [GOC:TermGenie]
is_a: GO:0032680 ! regulation of tumor necrosis factor production
is_a: GO:0050707 ! regulation of cytokine secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990774 ! tumor necrosis factor secretion
relationship: regulates GO:1990774 ! tumor necrosis factor secretion
created_by: sl
creation_date: 2015-07-09T19:50:02Z

[Term]
id: GO:1904468
name: negative regulation of tumor necrosis factor secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tumor necrosis factor secretion." [GO_REF:0000058, GOC:TermGenie, PMID:15560120]
synonym: "down regulation of cachectin secretion" EXACT [GOC:TermGenie]
synonym: "down regulation of TNF secretion" EXACT [GOC:TermGenie]
synonym: "down regulation of TNF superfamily, member 2 secretion" EXACT [GOC:TermGenie]
synonym: "down regulation of TNF-alpha secretion" EXACT [GOC:TermGenie]
synonym: "down regulation of Tnfa secretion" EXACT [GOC:TermGenie]
synonym: "down regulation of tumor necrosis factor alpha secretion" EXACT [GOC:TermGenie]
synonym: "down regulation of tumor necrosis factor ligand superfamily member 2 secretion" EXACT [GOC:TermGenie]
synonym: "down regulation of tumor necrosis factor secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of cachectin secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of TNF secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of TNF superfamily, member 2 secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of TNF-alpha secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of Tnfa secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of tumor necrosis factor alpha secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of tumor necrosis factor ligand superfamily member 2 secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of tumor necrosis factor secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of cachectin secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of TNF secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of TNF superfamily, member 2 secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of TNF-alpha secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of Tnfa secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of tumor necrosis factor alpha secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of tumor necrosis factor ligand superfamily member 2 secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of tumor necrosis factor secretion" EXACT [GOC:TermGenie]
synonym: "inhibition of cachectin secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of TNF secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of TNF superfamily, member 2 secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of TNF-alpha secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of Tnfa secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of tumor necrosis factor alpha secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of tumor necrosis factor ligand superfamily member 2 secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of tumor necrosis factor secretion" NARROW [GOC:TermGenie]
synonym: "negative regulation of cachectin secretion" EXACT [GOC:TermGenie]
synonym: "negative regulation of TNF secretion" EXACT [GOC:TermGenie]
synonym: "negative regulation of TNF superfamily, member 2 secretion" EXACT [GOC:TermGenie]
synonym: "negative regulation of TNF-alpha secretion" EXACT [GOC:TermGenie]
synonym: "negative regulation of Tnfa secretion" EXACT [GOC:TermGenie]
synonym: "negative regulation of tumor necrosis factor alpha secretion" EXACT [GOC:TermGenie]
synonym: "negative regulation of tumor necrosis factor ligand superfamily member 2 secretion" EXACT [GOC:TermGenie]
is_a: GO:0032720 ! negative regulation of tumor necrosis factor production
is_a: GO:0050710 ! negative regulation of cytokine secretion
is_a: GO:1904467 ! regulation of tumor necrosis factor secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990774 ! tumor necrosis factor secretion
relationship: negatively_regulates GO:1990774 ! tumor necrosis factor secretion
created_by: sl
creation_date: 2015-07-09T19:50:08Z

[Term]
id: GO:1904469
name: positive regulation of tumor necrosis factor secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tumor necrosis factor secretion." [GO_REF:0000058, GOC:TermGenie, PMID:15560120]
synonym: "activation of cachectin secretion" NARROW [GOC:TermGenie]
synonym: "activation of TNF secretion" NARROW [GOC:TermGenie]
synonym: "activation of TNF superfamily, member 2 secretion" NARROW [GOC:TermGenie]
synonym: "activation of TNF-alpha secretion" NARROW [GOC:TermGenie]
synonym: "activation of Tnfa secretion" NARROW [GOC:TermGenie]
synonym: "activation of tumor necrosis factor alpha secretion" NARROW [GOC:TermGenie]
synonym: "activation of tumor necrosis factor ligand superfamily member 2 secretion" NARROW [GOC:TermGenie]
synonym: "activation of tumor necrosis factor secretion" NARROW [GOC:TermGenie]
synonym: "positive regulation of cachectin secretion" EXACT [GOC:TermGenie]
synonym: "positive regulation of TNF secretion" EXACT [GOC:TermGenie]
synonym: "positive regulation of TNF superfamily, member 2 secretion" EXACT [GOC:TermGenie]
synonym: "positive regulation of TNF-alpha secretion" EXACT [GOC:TermGenie]
synonym: "positive regulation of Tnfa secretion" EXACT [GOC:TermGenie]
synonym: "positive regulation of tumor necrosis factor alpha secretion" EXACT [GOC:TermGenie]
synonym: "positive regulation of tumor necrosis factor ligand superfamily member 2 secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of cachectin secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of TNF secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of TNF superfamily, member 2 secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of TNF-alpha secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of Tnfa secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of tumor necrosis factor alpha secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of tumor necrosis factor ligand superfamily member 2 secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of tumor necrosis factor secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of cachectin secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of TNF secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of TNF superfamily, member 2 secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of TNF-alpha secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of Tnfa secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of tumor necrosis factor alpha secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of tumor necrosis factor ligand superfamily member 2 secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of tumor necrosis factor secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of cachectin secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of TNF secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of TNF superfamily, member 2 secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of TNF-alpha secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of Tnfa secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of tumor necrosis factor alpha secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of tumor necrosis factor ligand superfamily member 2 secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of tumor necrosis factor secretion" EXACT [GOC:TermGenie]
is_a: GO:0032760 ! positive regulation of tumor necrosis factor production
is_a: GO:0050715 ! positive regulation of cytokine secretion
is_a: GO:1904467 ! regulation of tumor necrosis factor secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990774 ! tumor necrosis factor secretion
relationship: positively_regulates GO:1990774 ! tumor necrosis factor secretion
created_by: sl
creation_date: 2015-07-09T19:50:14Z

[Term]
id: GO:1904470
name: regulation of endothelin secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endothelin secretion." [GO_REF:0000058, GOC:TermGenie, PMID:15560120]
synonym: "regulation of EDN1 secretion" NARROW [GOC:TermGenie]
synonym: "regulation of EDN2 secretion" NARROW [GOC:TermGenie]
synonym: "regulation of EDN3 secretion" NARROW [GOC:TermGenie]
synonym: "regulation of endothelin-1 secretion" NARROW [GOC:TermGenie]
synonym: "regulation of endothelin-2 secretion" NARROW [GOC:TermGenie]
synonym: "regulation of endothelin-3 secretion" NARROW [GOC:TermGenie]
is_a: GO:0050707 ! regulation of cytokine secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990775 ! endothelin secretion
relationship: regulates GO:1990775 ! endothelin secretion
created_by: sl
creation_date: 2015-07-09T19:57:57Z

[Term]
id: GO:1904471
name: negative regulation of endothelin secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelin secretion." [GO_REF:0000058, GOC:TermGenie, PMID:15560120]
synonym: "down regulation of EDN1 secretion" NARROW [GOC:TermGenie]
synonym: "down regulation of EDN2 secretion" NARROW [GOC:TermGenie]
synonym: "down regulation of EDN3 secretion" NARROW [GOC:TermGenie]
synonym: "down regulation of endothelin secretion" EXACT [GOC:TermGenie]
synonym: "down regulation of endothelin-1 secretion" NARROW [GOC:TermGenie]
synonym: "down regulation of endothelin-2 secretion" NARROW [GOC:TermGenie]
synonym: "down regulation of endothelin-3 secretion" NARROW [GOC:TermGenie]
synonym: "down-regulation of EDN1 secretion" NARROW [GOC:TermGenie]
synonym: "down-regulation of EDN2 secretion" NARROW [GOC:TermGenie]
synonym: "down-regulation of EDN3 secretion" NARROW [GOC:TermGenie]
synonym: "down-regulation of endothelin secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of endothelin-1 secretion" NARROW [GOC:TermGenie]
synonym: "down-regulation of endothelin-2 secretion" NARROW [GOC:TermGenie]
synonym: "down-regulation of endothelin-3 secretion" NARROW [GOC:TermGenie]
synonym: "downregulation of EDN1 secretion" NARROW [GOC:TermGenie]
synonym: "downregulation of EDN2 secretion" NARROW [GOC:TermGenie]
synonym: "downregulation of EDN3 secretion" NARROW [GOC:TermGenie]
synonym: "downregulation of endothelin secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of endothelin-1 secretion" NARROW [GOC:TermGenie]
synonym: "downregulation of endothelin-2 secretion" NARROW [GOC:TermGenie]
synonym: "downregulation of endothelin-3 secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of EDN1 secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of EDN2 secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of EDN3 secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of endothelin secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of endothelin-1 secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of endothelin-2 secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of endothelin-3 secretion" NARROW [GOC:TermGenie]
synonym: "negative regulation of EDN1 secretion" NARROW [GOC:TermGenie]
synonym: "negative regulation of EDN2 secretion" NARROW [GOC:TermGenie]
synonym: "negative regulation of EDN3 secretion" NARROW [GOC:TermGenie]
synonym: "negative regulation of endothelin-1 secretion" NARROW [GOC:TermGenie]
synonym: "negative regulation of endothelin-2 secretion" NARROW [GOC:TermGenie]
synonym: "negative regulation of endothelin-3 secretion" NARROW [GOC:TermGenie]
is_a: GO:0050710 ! negative regulation of cytokine secretion
is_a: GO:1904470 ! regulation of endothelin secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990775 ! endothelin secretion
relationship: negatively_regulates GO:1990775 ! endothelin secretion
created_by: sl
creation_date: 2015-07-09T19:58:03Z

[Term]
id: GO:1904472
name: positive regulation of endothelin secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endothelin secretion." [GO_REF:0000058, GOC:TermGenie, PMID:15560120]
synonym: "activation of EDN1 secretion" NARROW [GOC:TermGenie]
synonym: "activation of EDN2 secretion" NARROW [GOC:TermGenie]
synonym: "activation of EDN3 secretion" NARROW [GOC:TermGenie]
synonym: "activation of endothelin secretion" NARROW [GOC:TermGenie]
synonym: "activation of endothelin-1 secretion" NARROW [GOC:TermGenie]
synonym: "activation of endothelin-2 secretion" NARROW [GOC:TermGenie]
synonym: "activation of endothelin-3 secretion" NARROW [GOC:TermGenie]
synonym: "positive regulation of EDN1 secretion" NARROW [GOC:TermGenie]
synonym: "positive regulation of EDN2 secretion" NARROW [GOC:TermGenie]
synonym: "positive regulation of EDN3 secretion" NARROW [GOC:TermGenie]
synonym: "positive regulation of endothelin-1 secretion" NARROW [GOC:TermGenie]
synonym: "positive regulation of endothelin-2 secretion" NARROW [GOC:TermGenie]
synonym: "positive regulation of endothelin-3 secretion" NARROW [GOC:TermGenie]
synonym: "up regulation of EDN1 secretion" NARROW [GOC:TermGenie]
synonym: "up regulation of EDN2 secretion" NARROW [GOC:TermGenie]
synonym: "up regulation of EDN3 secretion" NARROW [GOC:TermGenie]
synonym: "up regulation of endothelin secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of endothelin-1 secretion" NARROW [GOC:TermGenie]
synonym: "up regulation of endothelin-2 secretion" NARROW [GOC:TermGenie]
synonym: "up regulation of endothelin-3 secretion" NARROW [GOC:TermGenie]
synonym: "up-regulation of EDN1 secretion" NARROW [GOC:TermGenie]
synonym: "up-regulation of EDN2 secretion" NARROW [GOC:TermGenie]
synonym: "up-regulation of EDN3 secretion" NARROW [GOC:TermGenie]
synonym: "up-regulation of endothelin secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of endothelin-1 secretion" NARROW [GOC:TermGenie]
synonym: "up-regulation of endothelin-2 secretion" NARROW [GOC:TermGenie]
synonym: "up-regulation of endothelin-3 secretion" NARROW [GOC:TermGenie]
synonym: "upregulation of EDN1 secretion" NARROW [GOC:TermGenie]
synonym: "upregulation of EDN2 secretion" NARROW [GOC:TermGenie]
synonym: "upregulation of EDN3 secretion" NARROW [GOC:TermGenie]
synonym: "upregulation of endothelin secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of endothelin-1 secretion" NARROW [GOC:TermGenie]
synonym: "upregulation of endothelin-2 secretion" NARROW [GOC:TermGenie]
synonym: "upregulation of endothelin-3 secretion" NARROW [GOC:TermGenie]
is_a: GO:0050715 ! positive regulation of cytokine secretion
is_a: GO:1904470 ! regulation of endothelin secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990775 ! endothelin secretion
relationship: positively_regulates GO:1990775 ! endothelin secretion
created_by: sl
creation_date: 2015-07-09T19:58:10Z

[Term]
id: GO:1904473
name: response to L-dopa
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-dopa stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:25044243]
is_a: GO:0043200 ! response to amino acid
is_a: GO:1904386 ! response to L-phenylalanine derivative
created_by: sl
creation_date: 2015-07-09T20:15:53Z

[Term]
id: GO:1904474
name: cellular response to L-dopa
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-dopa stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:25044243]
is_a: GO:0071230 ! cellular response to amino acid stimulus
is_a: GO:1904387 ! cellular response to L-phenylalanine derivative
is_a: GO:1904473 ! response to L-dopa
created_by: sl
creation_date: 2015-07-09T20:15:59Z

[Term]
id: GO:1904475
name: regulation of Ras GTPase binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Ras GTPase binding." [GO_REF:0000059, GOC:TermGenie, PMID:15798216]
synonym: "regulation of Ras interactor activity" RELATED [GOC:TermGenie]
is_a: GO:0043393 ! regulation of protein binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0017016 ! Ras GTPase binding
relationship: regulates GO:0017016 ! Ras GTPase binding
created_by: sl
creation_date: 2015-07-10T22:47:31Z

[Term]
id: GO:1904476
name: negative regulation of Ras GTPase binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of Ras GTPase binding." [GO_REF:0000059, GOC:TermGenie, PMID:15798216]
synonym: "down regulation of Ras GTPase binding" EXACT [GOC:TermGenie]
synonym: "down regulation of Ras interactor activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of Ras GTPase binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of Ras interactor activity" RELATED [GOC:TermGenie]
synonym: "downregulation of Ras GTPase binding" EXACT [GOC:TermGenie]
synonym: "downregulation of Ras interactor activity" RELATED [GOC:TermGenie]
synonym: "inhibition of Ras GTPase binding" NARROW [GOC:TermGenie]
synonym: "inhibition of Ras interactor activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of Ras interactor activity" RELATED [GOC:TermGenie]
is_a: GO:0032091 ! negative regulation of protein binding
is_a: GO:1904475 ! regulation of Ras GTPase binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0017016 ! Ras GTPase binding
relationship: negatively_regulates GO:0017016 ! Ras GTPase binding
created_by: sl
creation_date: 2015-07-10T22:47:38Z

[Term]
id: GO:1904477
name: positive regulation of Ras GTPase binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of Ras GTPase binding." [GO_REF:0000059, GOC:TermGenie, PMID:15798216]
synonym: "activation of Ras GTPase binding" NARROW [GOC:TermGenie]
synonym: "activation of Ras interactor activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of Ras interactor activity" RELATED [GOC:TermGenie]
synonym: "up regulation of Ras GTPase binding" EXACT [GOC:TermGenie]
synonym: "up regulation of Ras interactor activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of Ras GTPase binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of Ras interactor activity" RELATED [GOC:TermGenie]
synonym: "upregulation of Ras GTPase binding" EXACT [GOC:TermGenie]
synonym: "upregulation of Ras interactor activity" RELATED [GOC:TermGenie]
is_a: GO:0032092 ! positive regulation of protein binding
is_a: GO:1904475 ! regulation of Ras GTPase binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0017016 ! Ras GTPase binding
relationship: positively_regulates GO:0017016 ! Ras GTPase binding
created_by: sl
creation_date: 2015-07-10T22:47:43Z

[Term]
id: GO:1904478
name: regulation of intestinal absorption
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of intestinal absorption." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12469120]
is_a: GO:0044058 ! regulation of digestive system process
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050892 ! intestinal absorption
relationship: regulates GO:0050892 ! intestinal absorption
created_by: rl
creation_date: 2015-07-13T15:58:47Z

[Term]
id: GO:1904479
name: negative regulation of intestinal absorption
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of intestinal absorption." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12469120]
synonym: "down regulation of intestinal absorption" EXACT [GOC:TermGenie]
synonym: "down-regulation of intestinal absorption" EXACT [GOC:TermGenie]
synonym: "downregulation of intestinal absorption" EXACT [GOC:TermGenie]
synonym: "inhibition of intestinal absorption" NARROW [GOC:TermGenie]
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:0060457 ! negative regulation of digestive system process
is_a: GO:1904478 ! regulation of intestinal absorption
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0050892 ! intestinal absorption
relationship: negatively_regulates GO:0050892 ! intestinal absorption
created_by: rl
creation_date: 2015-07-13T15:58:54Z

[Term]
id: GO:1904480
name: positive regulation of intestinal absorption
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of intestinal absorption." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12469120]
synonym: "activation of intestinal absorption" NARROW [GOC:TermGenie]
synonym: "up regulation of intestinal absorption" EXACT [GOC:TermGenie]
synonym: "up-regulation of intestinal absorption" EXACT [GOC:TermGenie]
synonym: "upregulation of intestinal absorption" EXACT [GOC:TermGenie]
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:0060456 ! positive regulation of digestive system process
is_a: GO:1904478 ! regulation of intestinal absorption
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0050892 ! intestinal absorption
relationship: positively_regulates GO:0050892 ! intestinal absorption
created_by: rl
creation_date: 2015-07-13T15:59:00Z

[Term]
id: GO:1904481
name: response to tetrahydrofolate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetrahydrofolate stimulus." [GO_REF:0000071, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:24698160]
is_a: GO:0001101 ! response to acid chemical
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: hal
creation_date: 2015-07-14T14:49:17Z

[Term]
id: GO:1904482
name: cellular response to tetrahydrofolate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetrahydrofolate stimulus." [GO_REF:0000071, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:24698160]
is_a: GO:0071229 ! cellular response to acid chemical
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1904481 ! response to tetrahydrofolate
created_by: hal
creation_date: 2015-07-14T14:49:23Z

[Term]
id: GO:1904483
name: synthetic cannabinoid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with synthetic cannabinoid." [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:10700562]
is_a: GO:0005488 ! binding
created_by: mr
creation_date: 2015-07-14T22:30:09Z

[Term]
id: GO:1904484
name: cloacal gland development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cloacal gland over time, from its formation to the mature structure." [GO_REF:0000094, GOC:mr, GOC:TermGenie, PMID:18805421]
is_a: GO:0048732 ! gland development
created_by: mr
creation_date: 2015-07-15T22:14:39Z

[Term]
id: GO:1904486
name: response to 17alpha-ethynylestradiol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 17alpha-ethynylestradiol stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18805421]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033993 ! response to lipid
is_a: GO:0097305 ! response to alcohol
created_by: mr
creation_date: 2015-07-15T22:31:36Z

[Term]
id: GO:1904487
name: cellular response to 17alpha-ethynylestradiol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 17alpha-ethynylestradiol stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18805421]
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0097306 ! cellular response to alcohol
is_a: GO:1904486 ! response to 17alpha-ethynylestradiol
created_by: mr
creation_date: 2015-07-15T22:31:42Z

[Term]
id: GO:1904488
name: regulation of reactive oxygen species metabolic process by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A positive regulation of transcription from RNA polymerase II promoter that results in regulation of reactive oxygen species metabolic process." [GO_REF:0000063, GOC:kmv, GOC:TermGenie, PMID:25961505]
synonym: "regulation of reactive oxygen species metabolic process by activation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolic process by activation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolic process by positive regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolic process by positive regulation of global transcription from Pol II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolic process by positive regulation of transcription from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolic process by positive regulation of transcription from RNA polymerase II promoter, global" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolic process by stimulation of global transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolic process by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolic process by up regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolic process by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolic process by up-regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolic process by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolic process by upregulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolic process by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by activation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by activation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by positive regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by positive regulation of global transcription from Pol II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by positive regulation of transcription from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by positive regulation of transcription from RNA polymerase II promoter, global" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by stimulation of global transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by up regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by up-regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by upregulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by activation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by activation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by positive regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by positive regulation of global transcription from Pol II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by positive regulation of transcription from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by positive regulation of transcription from RNA polymerase II promoter, global" RELATED [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by stimulation of global transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by up regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by up-regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by upregulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
is_a: GO:2000377 ! regulation of reactive oxygen species metabolic process
intersection_of: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
intersection_of: regulates GO:0072593 ! reactive oxygen species metabolic process
relationship: regulates GO:0072593 ! reactive oxygen species metabolic process
created_by: kmv
creation_date: 2015-07-17T18:11:59Z

[Term]
id: GO:1904489
name: regulation of reactive oxygen species metabolic process by negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A negative regulation of transcription from RNA polymerase II promoter that results in regulation of reactive oxygen species metabolic process." [GO_REF:0000063, GOC:kmv, GOC:TermGenie, PMID:25961505]
synonym: "regulation of reactive oxygen species metabolic process by down regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolic process by down regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolic process by down-regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolic process by down-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolic process by downregulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolic process by downregulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolic process by inhibition of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolic process by inhibition of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolic process by negative regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolic process by negative regulation of global transcription from Pol II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolic process by negative regulation of transcription from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolic process by negative regulation of transcription from RNA polymerase II promoter, global" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by down regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by down regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by down-regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by down-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by downregulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by downregulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by inhibition of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by inhibition of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by negative regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by negative regulation of global transcription from Pol II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by negative regulation of transcription from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species metabolism by negative regulation of transcription from RNA polymerase II promoter, global" RELATED [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by down regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by down regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by down-regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by down-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by downregulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by downregulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by inhibition of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by inhibition of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by negative regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by negative regulation of global transcription from Pol II promoter" RELATED [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by negative regulation of transcription from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of ROS metabolic process by negative regulation of transcription from RNA polymerase II promoter, global" RELATED [GOC:TermGenie]
is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
is_a: GO:2000377 ! regulation of reactive oxygen species metabolic process
intersection_of: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
intersection_of: regulates GO:0072593 ! reactive oxygen species metabolic process
relationship: regulates GO:0072593 ! reactive oxygen species metabolic process
created_by: kmv
creation_date: 2015-07-17T18:12:06Z

[Term]
id: GO:1904490
name: negative regulation of mitochondrial unfolded protein response by negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A negative regulation of transcription from RNA polymerase II promoter that results in negative regulation of mitochondrial unfolded protein response." [GO_REF:0000063, GOC:kmv, GOC:TermGenie, PMID:25961505]
synonym: "negative regulation of mitochondrial unfolded protein response by down regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "negative regulation of mitochondrial unfolded protein response by down regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of mitochondrial unfolded protein response by down-regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "negative regulation of mitochondrial unfolded protein response by down-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of mitochondrial unfolded protein response by downregulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "negative regulation of mitochondrial unfolded protein response by downregulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of mitochondrial unfolded protein response by inhibition of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "negative regulation of mitochondrial unfolded protein response by inhibition of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of mitochondrial unfolded protein response by negative regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "negative regulation of mitochondrial unfolded protein response by negative regulation of global transcription from Pol II promoter" RELATED [GOC:TermGenie]
synonym: "negative regulation of mitochondrial unfolded protein response by negative regulation of transcription from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of mitochondrial unfolded protein response by negative regulation of transcription from RNA polymerase II promoter, global" RELATED [GOC:TermGenie]
synonym: "negative regulation of mtUPR by down regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "negative regulation of mtUPR by down regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of mtUPR by down-regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "negative regulation of mtUPR by down-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of mtUPR by downregulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "negative regulation of mtUPR by downregulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of mtUPR by inhibition of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "negative regulation of mtUPR by inhibition of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of mtUPR by negative regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "negative regulation of mtUPR by negative regulation of global transcription from Pol II promoter" RELATED [GOC:TermGenie]
synonym: "negative regulation of mtUPR by negative regulation of transcription from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of mtUPR by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "negative regulation of mtUPR by negative regulation of transcription from RNA polymerase II promoter, global" RELATED [GOC:TermGenie]
is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:0080135 ! regulation of cellular response to stress
intersection_of: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
intersection_of: negatively_regulates GO:0034514 ! mitochondrial unfolded protein response
relationship: negatively_regulates GO:0034514 ! mitochondrial unfolded protein response
created_by: kmv
creation_date: 2015-07-17T18:15:13Z

[Term]
id: GO:1904491
name: protein localization to ciliary transition zone
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a ciliary transition zone." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:21422230]
synonym: "protein localisation in ciliary transition zone" EXACT [GOC:TermGenie]
synonym: "protein localisation to ciliary transition zone" EXACT [GOC:TermGenie]
synonym: "protein localization in ciliary transition zone" EXACT [GOC:TermGenie]
is_a: GO:0097499 ! protein localization to nonmotile primary cilium
created_by: kmv
creation_date: 2015-07-17T20:43:21Z

[Term]
id: GO:1904492
name: Ac-Asp-Glu binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with Ac-Asp-Glu." [GO_REF:0000067, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:24863754]
is_a: GO:0043168 ! anion binding
is_a: GO:1900750 ! oligopeptide binding
created_by: hal
creation_date: 2015-07-20T10:32:49Z

[Term]
id: GO:1904493
name: tetrahydrofolyl-poly(glutamate) polymer binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with tetrahydrofolyl-poly(glutamate) polymer." [GO_REF:0000067, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:24863754]
is_a: GO:0005488 ! binding
created_by: hal
creation_date: 2015-07-20T10:34:28Z

[Term]
id: GO:1904494
name: regulation of substance P secretion, neurotransmission
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of substance P secretion, neurotransmission." [GO_REF:0000058, GOC:TermGenie, PMID:15292051]
is_a: GO:0046928 ! regulation of neurotransmitter secretion
is_a: GO:1904458 ! regulation of substance P secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990793 ! substance P secretion, neurotransmission
relationship: regulates GO:1990793 ! substance P secretion, neurotransmission
created_by: sl
creation_date: 2015-07-21T19:09:04Z

[Term]
id: GO:1904495
name: negative regulation of substance P secretion, neurotransmission
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of substance P secretion, neurotransmission." [GO_REF:0000058, GOC:TermGenie, PMID:15292051]
synonym: "down regulation of substance P secretion, neurotransmission" EXACT [GOC:TermGenie]
synonym: "down-regulation of substance P secretion, neurotransmission" EXACT [GOC:TermGenie]
synonym: "downregulation of substance P secretion, neurotransmission" EXACT [GOC:TermGenie]
synonym: "inhibition of substance P secretion, neurotransmission" NARROW [GOC:TermGenie]
is_a: GO:0046929 ! negative regulation of neurotransmitter secretion
is_a: GO:1904459 ! negative regulation of substance P secretion
is_a: GO:1904494 ! regulation of substance P secretion, neurotransmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990793 ! substance P secretion, neurotransmission
relationship: negatively_regulates GO:1990793 ! substance P secretion, neurotransmission
created_by: sl
creation_date: 2015-07-21T19:09:10Z

[Term]
id: GO:1904496
name: positive regulation of substance P secretion, neurotransmission
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of substance P secretion, neurotransmission." [GO_REF:0000058, GOC:TermGenie, PMID:15292051]
synonym: "activation of substance P secretion, neurotransmission" NARROW [GOC:TermGenie]
synonym: "up regulation of substance P secretion, neurotransmission" EXACT [GOC:TermGenie]
synonym: "up-regulation of substance P secretion, neurotransmission" EXACT [GOC:TermGenie]
synonym: "upregulation of substance P secretion, neurotransmission" EXACT [GOC:TermGenie]
is_a: GO:0001956 ! positive regulation of neurotransmitter secretion
is_a: GO:1904460 ! positive regulation of substance P secretion
is_a: GO:1904494 ! regulation of substance P secretion, neurotransmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990793 ! substance P secretion, neurotransmission
relationship: positively_regulates GO:1990793 ! substance P secretion, neurotransmission
created_by: sl
creation_date: 2015-07-21T19:09:16Z

[Term]
id: GO:1904497
name: heterochromatin assembly involved in chromatin silencing at centromere outer repeat region
namespace: biological_process
def: "Any heterochromatin assembly that is involved in chromatin silencing at the centromere outer repeat region." [GO_REF:0000060, GOC:TermGenie, PMID:24240238]
synonym: "establishment of heterochromatin architecture involved in chromatin silencing at centromere outer repeat region" EXACT [GOC:TermGenie]
synonym: "establishment of heterochromatin architecture involved in chromatin silencing at pericentric region" RELATED [GOC:TermGenie]
synonym: "heterochromatin assembly involved in chromatin silencing at pericentric region" RELATED [GOC:TermGenie]
synonym: "heterochromatin formation involved in chromatin silencing at centromere outer repeat region" EXACT [GOC:TermGenie]
synonym: "heterochromatin formation involved in chromatin silencing at pericentric region" RELATED [GOC:TermGenie]
is_a: GO:0070869 ! heterochromatin assembly involved in chromatin silencing
intersection_of: GO:0031507 ! heterochromatin assembly
intersection_of: part_of GO:1990141 ! chromatin silencing at centromere outer repeat region
relationship: part_of GO:1990141 ! chromatin silencing at centromere outer repeat region
created_by: mah
creation_date: 2015-07-22T14:25:43Z

[Term]
id: GO:1904498
name: protein localization to actomyosin contractile ring involved in mitotic cytokinesis
namespace: biological_process
def: "Any protein localization to actomyosin contractile ring that is involved in mitotic cytokinesis." [GO_REF:0000060, GOC:TermGenie, PMID:25688133]
synonym: "protein localisation to actomyosin contractile ring involved in cytokinesis after mitosis" EXACT [GOC:TermGenie]
synonym: "protein localisation to actomyosin contractile ring involved in mitotic cytokinesis" EXACT [GOC:TermGenie]
synonym: "protein localisation to mitotic actomyosin contractile ring" EXACT []
synonym: "protein localization to actomyosin contractile ring during mitotic cytokinesis" RELATED []
synonym: "protein localization to actomyosin contractile ring involved in cytokinesis after mitosis" EXACT [GOC:TermGenie]
synonym: "protein localization to mitotic actomyosin contractile ring" EXACT []
is_a: GO:1990179 ! protein localization to actomyosin contractile ring
intersection_of: GO:1990179 ! protein localization to actomyosin contractile ring
intersection_of: part_of GO:0000281 ! mitotic cytokinesis
relationship: part_of GO:0000281 ! mitotic cytokinesis
created_by: mah
creation_date: 2015-07-22T14:30:57Z

[Term]
id: GO:1904499
name: regulation of chromatin-mediated maintenance of transcription
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chromatin-mediated maintenance of transcription." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22723415]
is_a: GO:0006355 ! regulation of transcription, DNA-templated
is_a: GO:1903308 ! regulation of chromatin modification
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048096 ! chromatin-mediated maintenance of transcription
relationship: regulates GO:0048096 ! chromatin-mediated maintenance of transcription
created_by: nc
creation_date: 2015-07-24T09:31:08Z

[Term]
id: GO:1904500
name: negative regulation of chromatin-mediated maintenance of transcription
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chromatin-mediated maintenance of transcription." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22723415]
synonym: "down regulation of chromatin-mediated maintenance of transcription" EXACT [GOC:TermGenie]
synonym: "down-regulation of chromatin-mediated maintenance of transcription" EXACT [GOC:TermGenie]
synonym: "downregulation of chromatin-mediated maintenance of transcription" EXACT [GOC:TermGenie]
synonym: "inhibition of chromatin-mediated maintenance of transcription" NARROW [GOC:TermGenie]
is_a: GO:1903309 ! negative regulation of chromatin modification
is_a: GO:1904499 ! regulation of chromatin-mediated maintenance of transcription
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048096 ! chromatin-mediated maintenance of transcription
relationship: negatively_regulates GO:0048096 ! chromatin-mediated maintenance of transcription
created_by: nc
creation_date: 2015-07-24T09:31:14Z

[Term]
id: GO:1904501
name: positive regulation of chromatin-mediated maintenance of transcription
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chromatin-mediated maintenance of transcription." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22723415]
synonym: "activation of chromatin-mediated maintenance of transcription" NARROW [GOC:TermGenie]
synonym: "up regulation of chromatin-mediated maintenance of transcription" EXACT [GOC:TermGenie]
synonym: "up-regulation of chromatin-mediated maintenance of transcription" EXACT [GOC:TermGenie]
synonym: "upregulation of chromatin-mediated maintenance of transcription" EXACT [GOC:TermGenie]
is_a: GO:1903310 ! positive regulation of chromatin modification
is_a: GO:1904499 ! regulation of chromatin-mediated maintenance of transcription
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048096 ! chromatin-mediated maintenance of transcription
relationship: positively_regulates GO:0048096 ! chromatin-mediated maintenance of transcription
created_by: nc
creation_date: 2015-07-24T09:31:20Z

[Term]
id: GO:1904502
name: regulation of lipophagy
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lipophagy." [GO_REF:0000058, GOC:autophagy, GOC:dph, GOC:TermGenie, PMID:25383539]
is_a: GO:0016241 ! regulation of macroautophagy
is_a: GO:0050994 ! regulation of lipid catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061724 ! lipophagy
relationship: regulates GO:0061724 ! lipophagy
created_by: dph
creation_date: 2015-07-24T11:37:12Z

[Term]
id: GO:1904503
name: negative regulation of lipophagy
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lipophagy." [GO_REF:0000058, GOC:autophagy, GOC:dph, GOC:TermGenie, PMID:25383539]
synonym: "down regulation of lipophagy" EXACT [GOC:TermGenie]
synonym: "down-regulation of lipophagy" EXACT [GOC:TermGenie]
synonym: "downregulation of lipophagy" EXACT [GOC:TermGenie]
synonym: "inhibition of lipophagy" NARROW [GOC:TermGenie]
is_a: GO:0016242 ! negative regulation of macroautophagy
is_a: GO:0050995 ! negative regulation of lipid catabolic process
is_a: GO:1904502 ! regulation of lipophagy
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061724 ! lipophagy
relationship: negatively_regulates GO:0061724 ! lipophagy
created_by: dph
creation_date: 2015-07-24T11:37:18Z

[Term]
id: GO:1904504
name: positive regulation of lipophagy
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lipophagy." [GO_REF:0000058, GOC:autophagy, GOC:dph, GOC:TermGenie, PMID:25383539]
synonym: "activation of lipophagy" NARROW [GOC:TermGenie]
synonym: "up regulation of lipophagy" EXACT [GOC:TermGenie]
synonym: "up-regulation of lipophagy" EXACT [GOC:TermGenie]
synonym: "upregulation of lipophagy" EXACT [GOC:TermGenie]
is_a: GO:0016239 ! positive regulation of macroautophagy
is_a: GO:0050996 ! positive regulation of lipid catabolic process
is_a: GO:1904502 ! regulation of lipophagy
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061724 ! lipophagy
relationship: positively_regulates GO:0061724 ! lipophagy
created_by: dph
creation_date: 2015-07-24T11:37:24Z

[Term]
id: GO:1904505
name: regulation of telomere maintenance in response to DNA damage
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of telomere maintenance in response to DNA damage." [GO_REF:0000058, GOC:BHF, goc:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284]
synonym: "regulation of DNA damage response, telomere maintenance" EXACT [GOC:TermGenie]
is_a: GO:0032204 ! regulation of telomere maintenance
is_a: GO:2001020 ! regulation of response to DNA damage stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043247 ! telomere maintenance in response to DNA damage
relationship: regulates GO:0043247 ! telomere maintenance in response to DNA damage
created_by: nc
creation_date: 2015-07-24T16:05:55Z

[Term]
id: GO:1904506
name: negative regulation of telomere maintenance in response to DNA damage
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of telomere maintenance in response to DNA damage." [GO_REF:0000058, GOC:BHF, goc:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284]
synonym: "down regulation of DNA damage response, telomere maintenance" EXACT [GOC:TermGenie]
synonym: "down regulation of telomere maintenance in response to DNA damage" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA damage response, telomere maintenance" EXACT [GOC:TermGenie]
synonym: "down-regulation of telomere maintenance in response to DNA damage" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA damage response, telomere maintenance" EXACT [GOC:TermGenie]
synonym: "downregulation of telomere maintenance in response to DNA damage" EXACT [GOC:TermGenie]
synonym: "inhibition of DNA damage response, telomere maintenance" NARROW [GOC:TermGenie]
synonym: "inhibition of telomere maintenance in response to DNA damage" NARROW [GOC:TermGenie]
synonym: "negative regulation of DNA damage response, telomere maintenance" EXACT [GOC:TermGenie]
is_a: GO:0032205 ! negative regulation of telomere maintenance
is_a: GO:1904505 ! regulation of telomere maintenance in response to DNA damage
is_a: GO:2001021 ! negative regulation of response to DNA damage stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043247 ! telomere maintenance in response to DNA damage
relationship: negatively_regulates GO:0043247 ! telomere maintenance in response to DNA damage
created_by: nc
creation_date: 2015-07-24T16:06:02Z

[Term]
id: GO:1904507
name: positive regulation of telomere maintenance in response to DNA damage
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of telomere maintenance in response to DNA damage." [GO_REF:0000058, GOC:BHF, goc:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284]
synonym: "activation of DNA damage response, telomere maintenance" NARROW [GOC:TermGenie]
synonym: "activation of telomere maintenance in response to DNA damage" NARROW [GOC:TermGenie]
synonym: "positive regulation of DNA damage response, telomere maintenance" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA damage response, telomere maintenance" EXACT [GOC:TermGenie]
synonym: "up regulation of telomere maintenance in response to DNA damage" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA damage response, telomere maintenance" EXACT [GOC:TermGenie]
synonym: "up-regulation of telomere maintenance in response to DNA damage" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA damage response, telomere maintenance" EXACT [GOC:TermGenie]
synonym: "upregulation of telomere maintenance in response to DNA damage" EXACT [GOC:TermGenie]
is_a: GO:0032206 ! positive regulation of telomere maintenance
is_a: GO:1904505 ! regulation of telomere maintenance in response to DNA damage
is_a: GO:2001022 ! positive regulation of response to DNA damage stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043247 ! telomere maintenance in response to DNA damage
relationship: positively_regulates GO:0043247 ! telomere maintenance in response to DNA damage
created_by: nc
creation_date: 2015-07-24T16:06:09Z

[Term]
id: GO:1904508
name: regulation of protein localization to basolateral plasma membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to basolateral plasma membrane." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:26115433]
synonym: "regulation of protein localisation in basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "regulation of protein localisation to basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "regulation of protein localization in basolateral plasma membrane" EXACT [GOC:TermGenie]
is_a: GO:1903076 ! regulation of protein localization to plasma membrane
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1903361 ! protein localization to basolateral plasma membrane
relationship: regulates GO:1903361 ! protein localization to basolateral plasma membrane
created_by: kmv
creation_date: 2015-07-24T17:56:26Z

[Term]
id: GO:1904509
name: negative regulation of protein localization to basolateral plasma membrane
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to basolateral plasma membrane." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:26115433]
synonym: "down regulation of protein localisation in basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localisation to basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization in basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation in basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation to basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization in basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation in basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation to basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization in basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localisation in basolateral plasma membrane" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localisation to basolateral plasma membrane" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization in basolateral plasma membrane" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to basolateral plasma membrane" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation in basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localisation to basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localization in basolateral plasma membrane" EXACT [GOC:TermGenie]
is_a: GO:1903077 ! negative regulation of protein localization to plasma membrane
is_a: GO:1904508 ! regulation of protein localization to basolateral plasma membrane
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1903361 ! protein localization to basolateral plasma membrane
relationship: negatively_regulates GO:1903361 ! protein localization to basolateral plasma membrane
created_by: kmv
creation_date: 2015-07-24T17:56:32Z

[Term]
id: GO:1904510
name: positive regulation of protein localization to basolateral plasma membrane
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to basolateral plasma membrane." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:26115433]
synonym: "activation of protein localisation in basolateral plasma membrane" NARROW [GOC:TermGenie]
synonym: "activation of protein localisation to basolateral plasma membrane" NARROW [GOC:TermGenie]
synonym: "activation of protein localization in basolateral plasma membrane" NARROW [GOC:TermGenie]
synonym: "activation of protein localization to basolateral plasma membrane" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein localisation in basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localisation to basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localization in basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation in basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation to basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization in basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation in basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation to basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization in basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation in basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation to basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization in basolateral plasma membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to basolateral plasma membrane" EXACT [GOC:TermGenie]
is_a: GO:1903078 ! positive regulation of protein localization to plasma membrane
is_a: GO:1904508 ! regulation of protein localization to basolateral plasma membrane
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1903361 ! protein localization to basolateral plasma membrane
relationship: positively_regulates GO:1903361 ! protein localization to basolateral plasma membrane
created_by: kmv
creation_date: 2015-07-24T17:56:38Z

[Term]
id: GO:1904511
name: cytoplasmic microtubule plus-end
namespace: cellular_component
def: "Any microtubule plus-end that is part of a cytoplasmic microtubule." [GO_REF:0000064, GOC:TermGenie, PMID:15772152]
synonym: "growing microtubule plus end of cytoplasmic microtubule" EXACT [GOC:TermGenie]
synonym: "growing microtubule plus end of non-spindle-associated astral microtubule" NARROW [GOC:TermGenie]
synonym: "microtubule plus end of cytoplasmic microtubule" EXACT [GOC:TermGenie]
synonym: "microtubule plus end of non-spindle-associated astral microtubule" NARROW [GOC:TermGenie]
synonym: "microtubule plus-end of cytoplasmic microtubule" EXACT [GOC:TermGenie]
synonym: "microtubule plus-end of non-spindle-associated astral microtubule" NARROW [GOC:TermGenie]
is_a: GO:0035371 ! microtubule plus-end
is_a: GO:0044444 ! cytoplasmic part
intersection_of: GO:0035371 ! microtubule plus-end
intersection_of: part_of GO:0005881 ! cytoplasmic microtubule
relationship: part_of GO:0005881 ! cytoplasmic microtubule
created_by: mah
creation_date: 2015-07-27T13:05:11Z

[Term]
id: GO:1904512
name: regulation of initiation of premeiotic DNA replication
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of initiation of premeiotic DNA replication." [GO_REF:0000058, GOC:TermGenie, PMID:25891897]
synonym: "regulation of initiation of meiotic DNA synthesis" RELATED [GOC:TermGenie]
synonym: "regulation of initiation of premeiotic DNA synthesis" RELATED [GOC:TermGenie]
synonym: "regulation of meiotic DNA replication initiation" RELATED [GOC:TermGenie]
synonym: "regulation of premeiotic DNA replication initiation" EXACT [GOC:TermGenie]
is_a: GO:0030174 ! regulation of DNA-dependent DNA replication initiation
is_a: GO:0033262 ! regulation of nuclear cell cycle DNA replication
is_a: GO:0051445 ! regulation of meiotic cell cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072691 ! initiation of premeiotic DNA replication
relationship: regulates GO:0072691 ! initiation of premeiotic DNA replication
created_by: mah
creation_date: 2015-07-28T12:59:17Z

[Term]
id: GO:1904513
name: negative regulation of initiation of premeiotic DNA replication
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of initiation of premeiotic DNA replication." [GO_REF:0000058, GOC:TermGenie, PMID:25891897]
synonym: "down regulation of initiation of meiotic DNA synthesis" RELATED [GOC:TermGenie]
synonym: "down regulation of initiation of premeiotic DNA replication" EXACT [GOC:TermGenie]
synonym: "down regulation of initiation of premeiotic DNA synthesis" RELATED [GOC:TermGenie]
synonym: "down regulation of meiotic DNA replication initiation" RELATED [GOC:TermGenie]
synonym: "down regulation of premeiotic DNA replication initiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of initiation of meiotic DNA synthesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of initiation of premeiotic DNA replication" EXACT [GOC:TermGenie]
synonym: "down-regulation of initiation of premeiotic DNA synthesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of meiotic DNA replication initiation" RELATED [GOC:TermGenie]
synonym: "down-regulation of premeiotic DNA replication initiation" EXACT [GOC:TermGenie]
synonym: "downregulation of initiation of meiotic DNA synthesis" RELATED [GOC:TermGenie]
synonym: "downregulation of initiation of premeiotic DNA replication" EXACT [GOC:TermGenie]
synonym: "downregulation of initiation of premeiotic DNA synthesis" RELATED [GOC:TermGenie]
synonym: "downregulation of meiotic DNA replication initiation" RELATED [GOC:TermGenie]
synonym: "downregulation of premeiotic DNA replication initiation" EXACT [GOC:TermGenie]
synonym: "inhibition of initiation of meiotic DNA synthesis" RELATED [GOC:TermGenie]
synonym: "inhibition of initiation of premeiotic DNA replication" NARROW [GOC:TermGenie]
synonym: "inhibition of initiation of premeiotic DNA synthesis" RELATED [GOC:TermGenie]
synonym: "inhibition of meiotic DNA replication initiation" RELATED [GOC:TermGenie]
synonym: "inhibition of premeiotic DNA replication initiation" NARROW [GOC:TermGenie]
synonym: "negative regulation of initiation of meiotic DNA synthesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of initiation of premeiotic DNA synthesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of meiotic DNA replication initiation" RELATED [GOC:TermGenie]
synonym: "negative regulation of premeiotic DNA replication initiation" EXACT [GOC:TermGenie]
is_a: GO:0032297 ! negative regulation of DNA-dependent DNA replication initiation
is_a: GO:0051447 ! negative regulation of meiotic cell cycle
is_a: GO:1902576 ! negative regulation of nuclear cell cycle DNA replication
is_a: GO:1904512 ! regulation of initiation of premeiotic DNA replication
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072691 ! initiation of premeiotic DNA replication
relationship: negatively_regulates GO:0072691 ! initiation of premeiotic DNA replication
created_by: mah
creation_date: 2015-07-28T12:59:23Z

[Term]
id: GO:1904514
name: positive regulation of initiation of premeiotic DNA replication
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of initiation of premeiotic DNA replication." [GO_REF:0000058, GOC:TermGenie, PMID:25891897]
synonym: "activation of initiation of meiotic DNA synthesis" RELATED [GOC:TermGenie]
synonym: "activation of initiation of premeiotic DNA replication" NARROW [GOC:TermGenie]
synonym: "activation of initiation of premeiotic DNA synthesis" RELATED [GOC:TermGenie]
synonym: "activation of meiotic DNA replication initiation" RELATED [GOC:TermGenie]
synonym: "activation of premeiotic DNA replication initiation" NARROW [GOC:TermGenie]
synonym: "positive regulation of initiation of meiotic DNA synthesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of initiation of premeiotic DNA synthesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of meiotic DNA replication initiation" RELATED [GOC:TermGenie]
synonym: "positive regulation of premeiotic DNA replication initiation" EXACT [GOC:TermGenie]
synonym: "up regulation of initiation of meiotic DNA synthesis" RELATED [GOC:TermGenie]
synonym: "up regulation of initiation of premeiotic DNA replication" EXACT [GOC:TermGenie]
synonym: "up regulation of initiation of premeiotic DNA synthesis" RELATED [GOC:TermGenie]
synonym: "up regulation of meiotic DNA replication initiation" RELATED [GOC:TermGenie]
synonym: "up regulation of premeiotic DNA replication initiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of initiation of meiotic DNA synthesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of initiation of premeiotic DNA replication" EXACT [GOC:TermGenie]
synonym: "up-regulation of initiation of premeiotic DNA synthesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of meiotic DNA replication initiation" RELATED [GOC:TermGenie]
synonym: "up-regulation of premeiotic DNA replication initiation" EXACT [GOC:TermGenie]
synonym: "upregulation of initiation of meiotic DNA synthesis" RELATED [GOC:TermGenie]
synonym: "upregulation of initiation of premeiotic DNA replication" EXACT [GOC:TermGenie]
synonym: "upregulation of initiation of premeiotic DNA synthesis" RELATED [GOC:TermGenie]
synonym: "upregulation of meiotic DNA replication initiation" RELATED [GOC:TermGenie]
synonym: "upregulation of premeiotic DNA replication initiation" EXACT [GOC:TermGenie]
is_a: GO:0010571 ! positive regulation of nuclear cell cycle DNA replication
is_a: GO:0032298 ! positive regulation of DNA-dependent DNA replication initiation
is_a: GO:0051446 ! positive regulation of meiotic cell cycle
is_a: GO:1904512 ! regulation of initiation of premeiotic DNA replication
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072691 ! initiation of premeiotic DNA replication
relationship: positively_regulates GO:0072691 ! initiation of premeiotic DNA replication
created_by: mah
creation_date: 2015-07-28T12:59:29Z

[Term]
id: GO:1904515
name: positive regulation of TORC2 signaling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of TORC2 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:25590601]
synonym: "activation of TORC2 signal transduction" NARROW [GOC:TermGenie]
synonym: "activation of TORC2 signaling" NARROW [GOC:TermGenie]
synonym: "positive regulation of TORC2 signal transduction" EXACT [GOC:TermGenie]
synonym: "up regulation of TORC2 signal transduction" EXACT [GOC:TermGenie]
synonym: "up regulation of TORC2 signaling" EXACT [GOC:TermGenie]
synonym: "up-regulation of TORC2 signal transduction" EXACT [GOC:TermGenie]
synonym: "up-regulation of TORC2 signaling" EXACT [GOC:TermGenie]
synonym: "upregulation of TORC2 signal transduction" EXACT [GOC:TermGenie]
synonym: "upregulation of TORC2 signaling" EXACT [GOC:TermGenie]
is_a: GO:0032008 ! positive regulation of TOR signaling
is_a: GO:1903939 ! regulation of TORC2 signaling
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0038203 ! TORC2 signaling
relationship: positively_regulates GO:0038203 ! TORC2 signaling
created_by: al
creation_date: 2015-07-28T16:09:55Z

[Term]
id: GO:1904516
name: myofibroblast cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a myofibroblast cell." [GO_REF:0000085, GOC:TermGenie, PMID:23026405]
synonym: "MFB apoptosis" NARROW [GOC:TermGenie]
synonym: "MFB apoptotic process" EXACT [GOC:TermGenie]
synonym: "myofibroblast cell apoptosis" NARROW [GOC:TermGenie]
is_a: GO:0006915 ! apoptotic process
created_by: sl
creation_date: 2015-07-28T18:29:08Z

[Term]
id: GO:1904517
name: MgATP(2-) binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with MgATP(2-)." [GO_REF:0000067, GOC:bhm, GOC:TermGenie, PMID:20086079]
is_a: GO:0005488 ! binding
created_by: bhm
creation_date: 2015-07-29T13:40:02Z

[Term]
id: GO:1904518
name: protein localization to cytoplasmic microtubule plus-end
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location at a cytoplasmic microtubule plus-end." [GO_REF:0000087, GOC:TermGenie, PMID:15772152]
synonym: "protein localisation in cytoplasmic microtubule plus-end" EXACT [GOC:TermGenie]
synonym: "protein localisation to cytoplasmic microtubule plus-end" EXACT [GOC:TermGenie]
synonym: "protein localization in cytoplasmic microtubule plus-end" EXACT [GOC:TermGenie]
is_a: GO:1904825 ! protein localization to microtubule plus-end
created_by: mah
creation_date: 2015-07-29T14:46:05Z

[Term]
id: GO:1904519
name: protein localization to microtubule minus-end
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location at a microtubule minus-end." [GO_REF:0000087, GOC:TermGenie, PMID:25987607]
synonym: "protein localisation in microtubule minus-end" EXACT [GOC:TermGenie]
synonym: "protein localisation to microtubule minus-end" EXACT [GOC:TermGenie]
synonym: "protein localization in microtubule minus-end" EXACT [GOC:TermGenie]
is_a: GO:0035372 ! protein localization to microtubule
created_by: mah
creation_date: 2015-07-29T14:46:11Z

[Term]
id: GO:1904520
name: regulation of myofibroblast cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of myofibroblast cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:26119034]
synonym: "regulation of MFB apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of MFB apoptotic process" EXACT [GOC:TermGenie]
synonym: "regulation of myofibroblast cell apoptosis" NARROW [GOC:TermGenie]
is_a: GO:0042981 ! regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1904516 ! myofibroblast cell apoptotic process
relationship: regulates GO:1904516 ! myofibroblast cell apoptotic process
created_by: sl
creation_date: 2015-07-29T15:52:14Z

[Term]
id: GO:1904521
name: negative regulation of myofibroblast cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of myofibroblast cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:26119034]
synonym: "down regulation of MFB apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of MFB apoptotic process" EXACT [GOC:TermGenie]
synonym: "down regulation of myofibroblast cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of myofibroblast cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of MFB apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of MFB apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of myofibroblast cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of myofibroblast cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of MFB apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of MFB apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of myofibroblast cell apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of myofibroblast cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "inhibition of MFB apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of MFB apoptotic process" NARROW [GOC:TermGenie]
synonym: "inhibition of myofibroblast cell apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of myofibroblast cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of MFB apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of MFB apoptotic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of myofibroblast cell apoptosis" NARROW [GOC:TermGenie]
is_a: GO:0043066 ! negative regulation of apoptotic process
is_a: GO:1904520 ! regulation of myofibroblast cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1904516 ! myofibroblast cell apoptotic process
relationship: negatively_regulates GO:1904516 ! myofibroblast cell apoptotic process
created_by: sl
creation_date: 2015-07-29T15:52:20Z

[Term]
id: GO:1904522
name: positive regulation of myofibroblast cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of myofibroblast cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:26119034]
synonym: "activation of MFB apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of MFB apoptotic process" NARROW [GOC:TermGenie]
synonym: "activation of myofibroblast cell apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of myofibroblast cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of MFB apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of MFB apoptotic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of myofibroblast cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of MFB apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of MFB apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of myofibroblast cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of myofibroblast cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of MFB apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of MFB apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of myofibroblast cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of myofibroblast cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of MFB apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of MFB apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of myofibroblast cell apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of myofibroblast cell apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0043065 ! positive regulation of apoptotic process
is_a: GO:1904520 ! regulation of myofibroblast cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1904516 ! myofibroblast cell apoptotic process
relationship: positively_regulates GO:1904516 ! myofibroblast cell apoptotic process
created_by: sl
creation_date: 2015-07-29T15:52:26Z

[Term]
id: GO:1904523
name: regulation of DNA amplification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA amplification." [GO_REF:0000058, GOC:TermGenie, PMID:26195783]
is_a: GO:2000278 ! regulation of DNA biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006277 ! DNA amplification
relationship: regulates GO:0006277 ! DNA amplification
created_by: mcc
creation_date: 2015-07-29T16:24:13Z

[Term]
id: GO:1904524
name: negative regulation of DNA amplification
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA amplification." [GO_REF:0000058, GOC:TermGenie, PMID:26195783]
synonym: "down regulation of DNA amplification" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA amplification" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA amplification" EXACT [GOC:TermGenie]
synonym: "inhibition of DNA amplification" NARROW [GOC:TermGenie]
is_a: GO:1904523 ! regulation of DNA amplification
is_a: GO:2000279 ! negative regulation of DNA biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006277 ! DNA amplification
relationship: negatively_regulates GO:0006277 ! DNA amplification
created_by: mcc
creation_date: 2015-07-29T16:24:19Z

[Term]
id: GO:1904525
name: positive regulation of DNA amplification
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA amplification." [GO_REF:0000058, GOC:TermGenie, PMID:26195783]
synonym: "activation of DNA amplification" NARROW [GOC:TermGenie]
synonym: "up regulation of DNA amplification" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA amplification" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA amplification" EXACT [GOC:TermGenie]
is_a: GO:1904523 ! regulation of DNA amplification
is_a: GO:2000573 ! positive regulation of DNA biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006277 ! DNA amplification
relationship: positively_regulates GO:0006277 ! DNA amplification
created_by: mcc
creation_date: 2015-07-29T16:24:25Z

[Term]
id: GO:1904526
name: regulation of microtubule binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of microtubule binding." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:24520051]
synonym: "regulation of microtubule severing activity" RELATED [GOC:TermGenie]
synonym: "regulation of microtubule/chromatin interaction" RELATED [GOC:TermGenie]
is_a: GO:0043393 ! regulation of protein binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008017 ! microtubule binding
relationship: regulates GO:0008017 ! microtubule binding
created_by: als
creation_date: 2015-07-30T10:32:13Z

[Term]
id: GO:1904527
name: negative regulation of microtubule binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of microtubule binding." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:24520051]
synonym: "down regulation of microtubule binding" EXACT [GOC:TermGenie]
synonym: "down regulation of microtubule severing activity" RELATED [GOC:TermGenie]
synonym: "down regulation of microtubule/chromatin interaction" RELATED [GOC:TermGenie]
synonym: "down-regulation of microtubule binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of microtubule severing activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of microtubule/chromatin interaction" RELATED [GOC:TermGenie]
synonym: "downregulation of microtubule binding" EXACT [GOC:TermGenie]
synonym: "downregulation of microtubule severing activity" RELATED [GOC:TermGenie]
synonym: "downregulation of microtubule/chromatin interaction" RELATED [GOC:TermGenie]
synonym: "inhibition of microtubule binding" NARROW [GOC:TermGenie]
synonym: "inhibition of microtubule severing activity" RELATED [GOC:TermGenie]
synonym: "inhibition of microtubule/chromatin interaction" RELATED [GOC:TermGenie]
synonym: "negative regulation of microtubule severing activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of microtubule/chromatin interaction" RELATED [GOC:TermGenie]
is_a: GO:0032091 ! negative regulation of protein binding
is_a: GO:1904526 ! regulation of microtubule binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008017 ! microtubule binding
relationship: negatively_regulates GO:0008017 ! microtubule binding
created_by: als
creation_date: 2015-07-30T10:32:29Z

[Term]
id: GO:1904528
name: positive regulation of microtubule binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of microtubule binding." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:24520051]
synonym: "activation of microtubule binding" NARROW [GOC:TermGenie]
synonym: "activation of microtubule severing activity" RELATED [GOC:TermGenie]
synonym: "activation of microtubule/chromatin interaction" RELATED [GOC:TermGenie]
synonym: "positive regulation of microtubule severing activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of microtubule/chromatin interaction" RELATED [GOC:TermGenie]
synonym: "up regulation of microtubule binding" EXACT [GOC:TermGenie]
synonym: "up regulation of microtubule severing activity" RELATED [GOC:TermGenie]
synonym: "up regulation of microtubule/chromatin interaction" RELATED [GOC:TermGenie]
synonym: "up-regulation of microtubule binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of microtubule severing activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of microtubule/chromatin interaction" RELATED [GOC:TermGenie]
synonym: "upregulation of microtubule binding" EXACT [GOC:TermGenie]
synonym: "upregulation of microtubule severing activity" RELATED [GOC:TermGenie]
synonym: "upregulation of microtubule/chromatin interaction" RELATED [GOC:TermGenie]
is_a: GO:0032092 ! positive regulation of protein binding
is_a: GO:1904526 ! regulation of microtubule binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008017 ! microtubule binding
relationship: positively_regulates GO:0008017 ! microtubule binding
created_by: als
creation_date: 2015-07-30T10:32:36Z

[Term]
id: GO:1904529
name: regulation of actin filament binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of actin filament binding." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:24520051]
synonym: "regulation of actin cross-linking activity" RELATED [GOC:TermGenie]
synonym: "regulation of F-actin binding" EXACT [GOC:TermGenie]
is_a: GO:1904616 ! regulation of actin binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051015 ! actin filament binding
relationship: regulates GO:0051015 ! actin filament binding
created_by: als
creation_date: 2015-07-30T10:41:49Z

[Term]
id: GO:1904530
name: negative regulation of actin filament binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of actin filament binding." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:24520051]
synonym: "down regulation of actin cross-linking activity" RELATED [GOC:TermGenie]
synonym: "down regulation of actin filament binding" EXACT [GOC:TermGenie]
synonym: "down regulation of F-actin binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of actin cross-linking activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of actin filament binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of F-actin binding" EXACT [GOC:TermGenie]
synonym: "downregulation of actin cross-linking activity" RELATED [GOC:TermGenie]
synonym: "downregulation of actin filament binding" EXACT [GOC:TermGenie]
synonym: "downregulation of F-actin binding" EXACT [GOC:TermGenie]
synonym: "inhibition of actin cross-linking activity" RELATED [GOC:TermGenie]
synonym: "inhibition of actin filament binding" NARROW [GOC:TermGenie]
synonym: "inhibition of F-actin binding" NARROW [GOC:TermGenie]
synonym: "negative regulation of actin cross-linking activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of F-actin binding" EXACT [GOC:TermGenie]
is_a: GO:1904529 ! regulation of actin filament binding
is_a: GO:1904617 ! negative regulation of actin binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051015 ! actin filament binding
relationship: negatively_regulates GO:0051015 ! actin filament binding
created_by: als
creation_date: 2015-07-30T10:41:55Z

[Term]
id: GO:1904531
name: positive regulation of actin filament binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of actin filament binding." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:24520051]
synonym: "activation of actin cross-linking activity" RELATED [GOC:TermGenie]
synonym: "activation of actin filament binding" NARROW [GOC:TermGenie]
synonym: "activation of F-actin binding" NARROW [GOC:TermGenie]
synonym: "positive regulation of actin cross-linking activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of F-actin binding" EXACT [GOC:TermGenie]
synonym: "up regulation of actin cross-linking activity" RELATED [GOC:TermGenie]
synonym: "up regulation of actin filament binding" EXACT [GOC:TermGenie]
synonym: "up regulation of F-actin binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of actin cross-linking activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of actin filament binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of F-actin binding" EXACT [GOC:TermGenie]
synonym: "upregulation of actin cross-linking activity" RELATED [GOC:TermGenie]
synonym: "upregulation of actin filament binding" EXACT [GOC:TermGenie]
synonym: "upregulation of F-actin binding" EXACT [GOC:TermGenie]
is_a: GO:1904529 ! regulation of actin filament binding
is_a: GO:1904618 ! positive regulation of actin binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051015 ! actin filament binding
relationship: positively_regulates GO:0051015 ! actin filament binding
created_by: als
creation_date: 2015-07-30T10:42:01Z

[Term]
id: GO:1904532
name: obsolete ATP-dependent microtubule motor activity, minus-end-directed involved in microtubule-based movement
namespace: molecular_function
def: "OBSOLETE. Any ATP-dependent microtubule motor activity, minus-end-directed that is involved in microtubule-based movement." [GO_REF:0000061, GOC:TermGenie, PMID:25987607]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
is_obsolete: true
created_by: vw
creation_date: 2015-07-31T06:45:48Z

[Term]
id: GO:1904533
name: regulation of telomeric loop disassembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of telomeric loop disassembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284]
synonym: "regulation of T loop disassembly" EXACT [GOC:TermGenie]
is_a: GO:0032204 ! regulation of telomere maintenance
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0090657 ! telomeric loop disassembly
relationship: regulates GO:0090657 ! telomeric loop disassembly
created_by: nc
creation_date: 2015-07-31T17:14:58Z

[Term]
id: GO:1904534
name: negative regulation of telomeric loop disassembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of telomeric loop disassembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284]
synonym: "down regulation of T loop disassembly" EXACT [GOC:TermGenie]
synonym: "down regulation of telomeric loop disassembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of T loop disassembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of telomeric loop disassembly" EXACT [GOC:TermGenie]
synonym: "downregulation of T loop disassembly" EXACT [GOC:TermGenie]
synonym: "downregulation of telomeric loop disassembly" EXACT [GOC:TermGenie]
synonym: "inhibition of T loop disassembly" NARROW [GOC:TermGenie]
synonym: "inhibition of telomeric loop disassembly" NARROW [GOC:TermGenie]
synonym: "negative regulation of T loop disassembly" EXACT [GOC:TermGenie]
is_a: GO:0032205 ! negative regulation of telomere maintenance
is_a: GO:1904533 ! regulation of telomeric loop disassembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0090657 ! telomeric loop disassembly
relationship: negatively_regulates GO:0090657 ! telomeric loop disassembly
created_by: nc
creation_date: 2015-07-31T17:15:04Z

[Term]
id: GO:1904535
name: positive regulation of telomeric loop disassembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of telomeric loop disassembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284]
synonym: "activation of T loop disassembly" NARROW [GOC:TermGenie]
synonym: "activation of telomeric loop disassembly" NARROW [GOC:TermGenie]
synonym: "positive regulation of T loop disassembly" EXACT [GOC:TermGenie]
synonym: "up regulation of T loop disassembly" EXACT [GOC:TermGenie]
synonym: "up regulation of telomeric loop disassembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of T loop disassembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of telomeric loop disassembly" EXACT [GOC:TermGenie]
synonym: "upregulation of T loop disassembly" EXACT [GOC:TermGenie]
synonym: "upregulation of telomeric loop disassembly" EXACT [GOC:TermGenie]
is_a: GO:0032206 ! positive regulation of telomere maintenance
is_a: GO:1904533 ! regulation of telomeric loop disassembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0090657 ! telomeric loop disassembly
relationship: positively_regulates GO:0090657 ! telomeric loop disassembly
created_by: nc
creation_date: 2015-07-31T17:15:10Z

[Term]
id: GO:1904536
name: regulation of mitotic telomere tethering at nuclear periphery
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitotic telomere tethering at nuclear periphery." [GO_REF:0000058, GOC:TermGenie, PMID:22959349]
is_a: GO:0060341 ! regulation of cellular localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044820 ! mitotic telomere tethering at nuclear periphery
relationship: regulates GO:0044820 ! mitotic telomere tethering at nuclear periphery
created_by: al
creation_date: 2015-08-04T14:24:26Z

[Term]
id: GO:1904537
name: negative regulation of mitotic telomere tethering at nuclear periphery
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic telomere tethering at nuclear periphery." [GO_REF:0000058, GOC:TermGenie, PMID:22959349]
synonym: "down regulation of mitotic telomere tethering at nuclear periphery" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitotic telomere tethering at nuclear periphery" EXACT [GOC:TermGenie]
synonym: "downregulation of mitotic telomere tethering at nuclear periphery" EXACT [GOC:TermGenie]
synonym: "inhibition of mitotic telomere tethering at nuclear periphery" NARROW [GOC:TermGenie]
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:1904536 ! regulation of mitotic telomere tethering at nuclear periphery
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044820 ! mitotic telomere tethering at nuclear periphery
relationship: negatively_regulates GO:0044820 ! mitotic telomere tethering at nuclear periphery
created_by: al
creation_date: 2015-08-04T14:24:32Z

[Term]
id: GO:1904538
name: regulation of glycolytic process through fructose-6-phosphate
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glycolytic process through fructose-6-phosphate." [GO_REF:0000058, GOC:dph, GOC:TermGenie, ISBN:0201090910, ISBN:0879010479]
synonym: "regulation of glycolysis through fructose-6-phosphate" EXACT [GOC:TermGenie]
is_a: GO:0006110 ! regulation of glycolytic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061615 ! glycolytic process through fructose-6-phosphate
relationship: regulates GO:0061615 ! glycolytic process through fructose-6-phosphate
created_by: dph
creation_date: 2015-08-07T11:35:10Z

[Term]
id: GO:1904539
name: negative regulation of glycolytic process through fructose-6-phosphate
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glycolytic process through fructose-6-phosphate." [GO_REF:0000058, GOC:dph, GOC:TermGenie, ISBN:0201090910, ISBN:0879010479]
synonym: "down regulation of glycolysis through fructose-6-phosphate" EXACT [GOC:TermGenie]
synonym: "down regulation of glycolytic process through fructose-6-phosphate" EXACT [GOC:TermGenie]
synonym: "down-regulation of glycolysis through fructose-6-phosphate" EXACT [GOC:TermGenie]
synonym: "down-regulation of glycolytic process through fructose-6-phosphate" EXACT [GOC:TermGenie]
synonym: "downregulation of glycolysis through fructose-6-phosphate" EXACT [GOC:TermGenie]
synonym: "downregulation of glycolytic process through fructose-6-phosphate" EXACT [GOC:TermGenie]
synonym: "inhibition of glycolysis through fructose-6-phosphate" NARROW [GOC:TermGenie]
synonym: "inhibition of glycolytic process through fructose-6-phosphate" NARROW [GOC:TermGenie]
synonym: "negative regulation of glycolysis through fructose-6-phosphate" EXACT [GOC:TermGenie]
is_a: GO:0045820 ! negative regulation of glycolytic process
is_a: GO:1904538 ! regulation of glycolytic process through fructose-6-phosphate
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061615 ! glycolytic process through fructose-6-phosphate
relationship: negatively_regulates GO:0061615 ! glycolytic process through fructose-6-phosphate
created_by: dph
creation_date: 2015-08-07T11:35:16Z

[Term]
id: GO:1904540
name: positive regulation of glycolytic process through fructose-6-phosphate
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glycolytic process through fructose-6-phosphate." [GO_REF:0000058, GOC:dph, GOC:TermGenie, ISBN:0201090910, ISBN:0879010479]
synonym: "activation of glycolysis through fructose-6-phosphate" NARROW [GOC:TermGenie]
synonym: "activation of glycolytic process through fructose-6-phosphate" NARROW [GOC:TermGenie]
synonym: "positive regulation of glycolysis through fructose-6-phosphate" EXACT [GOC:TermGenie]
synonym: "up regulation of glycolysis through fructose-6-phosphate" EXACT [GOC:TermGenie]
synonym: "up regulation of glycolytic process through fructose-6-phosphate" EXACT [GOC:TermGenie]
synonym: "up-regulation of glycolysis through fructose-6-phosphate" EXACT [GOC:TermGenie]
synonym: "up-regulation of glycolytic process through fructose-6-phosphate" EXACT [GOC:TermGenie]
synonym: "upregulation of glycolysis through fructose-6-phosphate" EXACT [GOC:TermGenie]
synonym: "upregulation of glycolytic process through fructose-6-phosphate" EXACT [GOC:TermGenie]
is_a: GO:0045821 ! positive regulation of glycolytic process
is_a: GO:1904538 ! regulation of glycolytic process through fructose-6-phosphate
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061615 ! glycolytic process through fructose-6-phosphate
relationship: positively_regulates GO:0061615 ! glycolytic process through fructose-6-phosphate
created_by: dph
creation_date: 2015-08-07T11:35:22Z

[Term]
id: GO:1904541
name: fungal-type cell wall disassembly involved in conjugation with cellular fusion
namespace: biological_process
def: "Any fungal-type cell wall disassembly that is involved in conjugation with cellular fusion." [GO_REF:0000060, GOC:TermGenie, PMID:25825517]
synonym: "fungal-type cell wall disassembly involved in cell fusion" RELATED [GOC:TermGenie]
synonym: "fungal-type cell wall disassembly involved in mating" RELATED [GOC:TermGenie]
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0070871 ! cell wall organization involved in conjugation with cellular fusion
is_a: GO:0071853 ! fungal-type cell wall disassembly
intersection_of: GO:0071853 ! fungal-type cell wall disassembly
intersection_of: part_of GO:0000747 ! conjugation with cellular fusion
relationship: part_of GO:0000747 ! conjugation with cellular fusion
created_by: al
creation_date: 2015-08-10T17:12:51Z

[Term]
id: GO:1904542
name: regulation of free ubiquitin chain polymerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of free ubiquitin chain polymerization." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:24660806]
comment: An example of this is PARK2 in human (UniProt symbol O60260) in PMID:24660806 (inferred from mutant phenotype).
is_a: GO:0010993 ! regulation of ubiquitin homeostasis
is_a: GO:0032271 ! regulation of protein polymerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010994 ! free ubiquitin chain polymerization
relationship: regulates GO:0010994 ! free ubiquitin chain polymerization
created_by: pad
creation_date: 2015-08-11T11:44:53Z

[Term]
id: GO:1904543
name: negative regulation of free ubiquitin chain polymerization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of free ubiquitin chain polymerization." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:24660806]
comment: An example of this is PARK2 in human (UniProt symbol O60260) in PMID:24660806 (inferred from mutant phenotype).
synonym: "down regulation of free ubiquitin chain polymerization" EXACT [GOC:TermGenie]
synonym: "down-regulation of free ubiquitin chain polymerization" EXACT [GOC:TermGenie]
synonym: "downregulation of free ubiquitin chain polymerization" EXACT [GOC:TermGenie]
synonym: "inhibition of free ubiquitin chain polymerization" NARROW [GOC:TermGenie]
is_a: GO:0032272 ! negative regulation of protein polymerization
is_a: GO:1904542 ! regulation of free ubiquitin chain polymerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010994 ! free ubiquitin chain polymerization
relationship: negatively_regulates GO:0010994 ! free ubiquitin chain polymerization
created_by: pad
creation_date: 2015-08-11T11:45:00Z

[Term]
id: GO:1904544
name: positive regulation of free ubiquitin chain polymerization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of free ubiquitin chain polymerization." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:24660806]
comment: An example of this is PARK2 in human (UniProt symbol O60260) in PMID:24660806 (inferred from mutant phenotype).
synonym: "activation of free ubiquitin chain polymerization" NARROW [GOC:TermGenie]
synonym: "up regulation of free ubiquitin chain polymerization" EXACT [GOC:TermGenie]
synonym: "up-regulation of free ubiquitin chain polymerization" EXACT [GOC:TermGenie]
synonym: "upregulation of free ubiquitin chain polymerization" EXACT [GOC:TermGenie]
is_a: GO:0032273 ! positive regulation of protein polymerization
is_a: GO:1904542 ! regulation of free ubiquitin chain polymerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010994 ! free ubiquitin chain polymerization
relationship: positively_regulates GO:0010994 ! free ubiquitin chain polymerization
created_by: pad
creation_date: 2015-08-11T11:45:06Z

[Term]
id: GO:1904546
name: obsolete negative regulation of cAMP-dependent protein kinase activity involved in negative regulation of glucose mediated signaling pathway
namespace: biological_process
def: "OBSOLETE. Any negative regulation of cAMP-dependent protein kinase activity that is involved in negative regulation of glucose mediated signaling pathway." [GO_REF:0000060, GOC:TermGenie, PMID:21118717]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "negative regulation of 3',5' cAMP-dependent protein kinase activity involved in down regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of 3',5' cAMP-dependent protein kinase activity involved in down regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of 3',5' cAMP-dependent protein kinase activity involved in down-regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of 3',5' cAMP-dependent protein kinase activity involved in down-regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of 3',5' cAMP-dependent protein kinase activity involved in downregulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of 3',5' cAMP-dependent protein kinase activity involved in downregulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of 3',5' cAMP-dependent protein kinase activity involved in inhibition of glucose mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of 3',5' cAMP-dependent protein kinase activity involved in inhibition of glucose mediated signalling" NARROW [GOC:TermGenie]
synonym: "negative regulation of 3',5' cAMP-dependent protein kinase activity involved in negative regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of 3',5' cAMP-dependent protein kinase activity involved in negative regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of 3',5'-cAMP-dependent protein kinase activity involved in down regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of 3',5'-cAMP-dependent protein kinase activity involved in down regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of 3',5'-cAMP-dependent protein kinase activity involved in down-regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of 3',5'-cAMP-dependent protein kinase activity involved in down-regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of 3',5'-cAMP-dependent protein kinase activity involved in downregulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of 3',5'-cAMP-dependent protein kinase activity involved in downregulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of 3',5'-cAMP-dependent protein kinase activity involved in inhibition of glucose mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of 3',5'-cAMP-dependent protein kinase activity involved in inhibition of glucose mediated signalling" NARROW [GOC:TermGenie]
synonym: "negative regulation of 3',5'-cAMP-dependent protein kinase activity involved in negative regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of 3',5'-cAMP-dependent protein kinase activity involved in negative regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity involved in down regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity involved in down regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity involved in down-regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity involved in down-regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity involved in downregulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity involved in downregulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity involved in inhibition of glucose mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity involved in inhibition of glucose mediated signalling" NARROW [GOC:TermGenie]
synonym: "negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity involved in negative regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity involved in negative regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of AMPK involved in down regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of AMPK involved in down regulation of glucose mediated signalling" RELATED [GOC:TermGenie]
synonym: "negative regulation of AMPK involved in down-regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of AMPK involved in down-regulation of glucose mediated signalling" RELATED [GOC:TermGenie]
synonym: "negative regulation of AMPK involved in downregulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of AMPK involved in downregulation of glucose mediated signalling" RELATED [GOC:TermGenie]
synonym: "negative regulation of AMPK involved in inhibition of glucose mediated signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of AMPK involved in inhibition of glucose mediated signalling" RELATED [GOC:TermGenie]
synonym: "negative regulation of AMPK involved in negative regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of AMPK involved in negative regulation of glucose mediated signalling" RELATED [GOC:TermGenie]
synonym: "negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity involved in down regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity involved in down regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity involved in down-regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity involved in down-regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity involved in downregulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity involved in downregulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity involved in inhibition of glucose mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity involved in inhibition of glucose mediated signalling" NARROW [GOC:TermGenie]
synonym: "negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity involved in negative regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity involved in negative regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of cAMP-dependent protein kinase activity involved in down regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of cAMP-dependent protein kinase activity involved in down regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of cAMP-dependent protein kinase activity involved in down-regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of cAMP-dependent protein kinase activity involved in down-regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of cAMP-dependent protein kinase activity involved in downregulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of cAMP-dependent protein kinase activity involved in downregulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of cAMP-dependent protein kinase activity involved in inhibition of glucose mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of cAMP-dependent protein kinase activity involved in inhibition of glucose mediated signalling" NARROW [GOC:TermGenie]
synonym: "negative regulation of cAMP-dependent protein kinase activity involved in negative regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity involved in down regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity involved in down regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity involved in down-regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity involved in down-regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity involved in downregulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity involved in downregulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity involved in inhibition of glucose mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity involved in inhibition of glucose mediated signalling" NARROW [GOC:TermGenie]
synonym: "negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity involved in negative regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity involved in negative regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of cyclic AMP-dependent protein kinase activity involved in down regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of cyclic AMP-dependent protein kinase activity involved in down regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of cyclic AMP-dependent protein kinase activity involved in down-regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of cyclic AMP-dependent protein kinase activity involved in down-regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of cyclic AMP-dependent protein kinase activity involved in downregulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of cyclic AMP-dependent protein kinase activity involved in downregulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of cyclic AMP-dependent protein kinase activity involved in inhibition of glucose mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of cyclic AMP-dependent protein kinase activity involved in inhibition of glucose mediated signalling" NARROW [GOC:TermGenie]
synonym: "negative regulation of cyclic AMP-dependent protein kinase activity involved in negative regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of cyclic AMP-dependent protein kinase activity involved in negative regulation of glucose mediated signalling" EXACT [GOC:TermGenie]
synonym: "negative regulation of PKA C involved in down regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of PKA C involved in down regulation of glucose mediated signalling" RELATED [GOC:TermGenie]
synonym: "negative regulation of PKA C involved in down-regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of PKA C involved in down-regulation of glucose mediated signalling" RELATED [GOC:TermGenie]
synonym: "negative regulation of PKA C involved in downregulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of PKA C involved in downregulation of glucose mediated signalling" RELATED [GOC:TermGenie]
synonym: "negative regulation of PKA C involved in inhibition of glucose mediated signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of PKA C involved in inhibition of glucose mediated signalling" RELATED [GOC:TermGenie]
synonym: "negative regulation of PKA C involved in negative regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of PKA C involved in negative regulation of glucose mediated signalling" RELATED [GOC:TermGenie]
synonym: "negative regulation of PKA involved in down regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of PKA involved in down regulation of glucose mediated signalling" RELATED [GOC:TermGenie]
synonym: "negative regulation of PKA involved in down-regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of PKA involved in down-regulation of glucose mediated signalling" RELATED [GOC:TermGenie]
synonym: "negative regulation of PKA involved in downregulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of PKA involved in downregulation of glucose mediated signalling" RELATED [GOC:TermGenie]
synonym: "negative regulation of PKA involved in inhibition of glucose mediated signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of PKA involved in inhibition of glucose mediated signalling" RELATED [GOC:TermGenie]
synonym: "negative regulation of PKA involved in negative regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of PKA involved in negative regulation of glucose mediated signalling" RELATED [GOC:TermGenie]
synonym: "negative regulation of protein kinase A activity involved in down regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of protein kinase A activity involved in down regulation of glucose mediated signalling" RELATED [GOC:TermGenie]
synonym: "negative regulation of protein kinase A activity involved in down-regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of protein kinase A activity involved in down-regulation of glucose mediated signalling" RELATED [GOC:TermGenie]
synonym: "negative regulation of protein kinase A activity involved in downregulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of protein kinase A activity involved in downregulation of glucose mediated signalling" RELATED [GOC:TermGenie]
synonym: "negative regulation of protein kinase A activity involved in inhibition of glucose mediated signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of protein kinase A activity involved in inhibition of glucose mediated signalling" RELATED [GOC:TermGenie]
synonym: "negative regulation of protein kinase A activity involved in negative regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of protein kinase A activity involved in negative regulation of glucose mediated signalling" RELATED [GOC:TermGenie]
synonym: "negative regulation of STK22 involved in down regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of STK22 involved in down regulation of glucose mediated signalling" RELATED [GOC:TermGenie]
synonym: "negative regulation of STK22 involved in down-regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of STK22 involved in down-regulation of glucose mediated signalling" RELATED [GOC:TermGenie]
synonym: "negative regulation of STK22 involved in downregulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of STK22 involved in downregulation of glucose mediated signalling" RELATED [GOC:TermGenie]
synonym: "negative regulation of STK22 involved in inhibition of glucose mediated signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of STK22 involved in inhibition of glucose mediated signalling" RELATED [GOC:TermGenie]
synonym: "negative regulation of STK22 involved in negative regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of STK22 involved in negative regulation of glucose mediated signalling" RELATED [GOC:TermGenie]
is_obsolete: true
created_by: al
creation_date: 2015-08-12T09:48:46Z

[Term]
id: GO:1904547
name: regulation of cellular response to glucose starvation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular response to glucose starvation." [GO_REF:0000058, GOC:TermGenie, PMID:21118717]
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0032107 ! regulation of response to nutrient levels
is_a: GO:0080135 ! regulation of cellular response to stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042149 ! cellular response to glucose starvation
relationship: regulates GO:0042149 ! cellular response to glucose starvation
created_by: al
creation_date: 2015-08-12T09:57:52Z

[Term]
id: GO:1904550
name: response to arachidonic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arachidonic acid stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16382163]
is_a: GO:0070542 ! response to fatty acid
created_by: sl
creation_date: 2015-08-13T20:53:24Z

[Term]
id: GO:1904551
name: cellular response to arachidonic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arachidonic acid stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16382163]
is_a: GO:0071398 ! cellular response to fatty acid
is_a: GO:1904550 ! response to arachidonic acid
created_by: sl
creation_date: 2015-08-13T20:53:31Z

[Term]
id: GO:1904552
name: regulation of chemotaxis to arachidonic acid
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chemotaxis to arachidonic acid." [GO_REF:0000058, GOC:TermGenie, PMID:16382163]
is_a: GO:0050920 ! regulation of chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034670 ! chemotaxis to arachidonic acid
relationship: regulates GO:0034670 ! chemotaxis to arachidonic acid
created_by: sl
creation_date: 2015-08-13T21:08:14Z

[Term]
id: GO:1904553
name: negative regulation of chemotaxis to arachidonic acid
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chemotaxis to arachidonic acid." [GO_REF:0000058, GOC:TermGenie, PMID:16382163]
synonym: "down regulation of chemotaxis to arachidonic acid" EXACT [GOC:TermGenie]
synonym: "down-regulation of chemotaxis to arachidonic acid" EXACT [GOC:TermGenie]
synonym: "downregulation of chemotaxis to arachidonic acid" EXACT [GOC:TermGenie]
synonym: "inhibition of chemotaxis to arachidonic acid" NARROW [GOC:TermGenie]
is_a: GO:0050922 ! negative regulation of chemotaxis
is_a: GO:1904552 ! regulation of chemotaxis to arachidonic acid
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034670 ! chemotaxis to arachidonic acid
relationship: negatively_regulates GO:0034670 ! chemotaxis to arachidonic acid
created_by: sl
creation_date: 2015-08-13T21:08:20Z

[Term]
id: GO:1904554
name: positive regulation of chemotaxis to arachidonic acid
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chemotaxis to arachidonic acid." [GO_REF:0000058, GOC:TermGenie, PMID:16382163]
synonym: "activation of chemotaxis to arachidonic acid" NARROW [GOC:TermGenie]
synonym: "up regulation of chemotaxis to arachidonic acid" EXACT [GOC:TermGenie]
synonym: "up-regulation of chemotaxis to arachidonic acid" EXACT [GOC:TermGenie]
synonym: "upregulation of chemotaxis to arachidonic acid" EXACT [GOC:TermGenie]
is_a: GO:0050921 ! positive regulation of chemotaxis
is_a: GO:1904552 ! regulation of chemotaxis to arachidonic acid
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034670 ! chemotaxis to arachidonic acid
relationship: positively_regulates GO:0034670 ! chemotaxis to arachidonic acid
created_by: sl
creation_date: 2015-08-13T21:08:27Z

[Term]
id: GO:1904555
name: L-proline transmembrane transport
namespace: biological_process
def: "The directed movement of L-proline across a membrane." [GO_REF:0000069, GOC:kmv, GOC:TermGenie]
is_a: GO:0035524 ! proline transmembrane transport
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport
created_by: pr
creation_date: 2015-08-14T14:21:06Z

[Term]
id: GO:1904556
name: L-tryptophan transmembrane transport
namespace: biological_process
def: "The directed movement of L-tryptophan across a membrane." [GO_REF:0000069, GOC:kmv, GOC:TermGenie]
is_a: GO:0015827 ! tryptophan transport
is_a: GO:0098655 ! cation transmembrane transport
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport
created_by: pr
creation_date: 2015-08-14T14:21:13Z

[Term]
id: GO:1904557
name: L-alanine transmembrane transport
namespace: biological_process
def: "The directed movement of L-alanine across a membrane." [GO_REF:0000069, GOC:kmv, GOC:TermGenie]
is_a: GO:0015808 ! L-alanine transport
is_a: GO:0098655 ! cation transmembrane transport
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport
created_by: pr
creation_date: 2015-08-14T14:21:29Z

[Term]
id: GO:1904558
name: response to dextromethorphan
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dextromethorphan stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:25796330]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0045472 ! response to ether
created_by: mr
creation_date: 2015-08-14T16:09:17Z

[Term]
id: GO:1904559
name: cellular response to dextromethorphan
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dextromethorphan stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:25796330]
is_a: GO:0071362 ! cellular response to ether
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:1904558 ! response to dextromethorphan
created_by: mr
creation_date: 2015-08-14T16:09:24Z

[Term]
id: GO:1904560
name: response to diphenidol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diphenidol stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:25796330]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0097305 ! response to alcohol
created_by: mr
creation_date: 2015-08-14T16:09:31Z

[Term]
id: GO:1904561
name: cellular response to diphenidol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diphenidol stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:25796330]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:0097306 ! cellular response to alcohol
is_a: GO:1904560 ! response to diphenidol
created_by: mr
creation_date: 2015-08-14T16:09:37Z

[Term]
id: GO:1904562
name: phosphatidylinositol 5-phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phosphatidylinositol 5-phosphate." [GO_REF:0000068, GOC:autophagy, GOC:dph, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:23916588]
synonym: "phosphatidylinositol 5-phosphate metabolism" EXACT [GOC:TermGenie]
is_a: GO:0046488 ! phosphatidylinositol metabolic process
created_by: dph
creation_date: 2015-08-18T16:21:44Z

[Term]
id: GO:1904563
name: phosphatidylinositol 5-phosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phosphatidylinositol 5-phosphate." [GO_REF:0000068, GOC:autophagy, GOC:dph, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:23916588]
synonym: "phosphatidylinositol 5-phosphate anabolism" EXACT [GOC:TermGenie]
synonym: "phosphatidylinositol 5-phosphate biosynthesis" EXACT [GOC:TermGenie]
synonym: "phosphatidylinositol 5-phosphate formation" EXACT [GOC:TermGenie]
synonym: "phosphatidylinositol 5-phosphate synthesis" EXACT [GOC:TermGenie]
is_a: GO:0006661 ! phosphatidylinositol biosynthetic process
is_a: GO:1904562 ! phosphatidylinositol 5-phosphate metabolic process
created_by: dph
creation_date: 2015-08-18T16:21:50Z

[Term]
id: GO:1904564
name: Nbp35-Cfd1 ATPase complex
namespace: cellular_component
def: "An iron-sulfur cluster assembly complex that is capable of weak ATPase activity. In yeast it consists of two subunits, Nbp35 and Cfd1." [GO_REF:0000088, GOC:bhm, GOC:rb, GOC:TermGenie, IntAct:EBI-11666137, PMID:26195633]
comment: An example of this is the yeast Nbp35-Cfd1 complex (IDA).
is_a: GO:1904949 ! ATPase complex
is_a: GO:1990229 ! iron-sulfur cluster assembly complex
created_by: rb
creation_date: 2015-08-18T22:50:29Z

[Term]
id: GO:1904565
name: response to 1-oleoyl-sn-glycerol 3-phosphate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-oleoyl-sn-glycerol 3-phosphate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:12139919]
synonym: "response to 1-oleoyl lysophosphatidic acid" EXACT []
synonym: "response to LPA" EXACT []
synonym: "response to lysophosphatidic acid" EXACT []
synonym: "response to oleoyl lysophosphatidic acid" EXACT []
synonym: "response to oleoyl-L-alpha-lysophosphatidic acid" EXACT []
is_a: GO:0033993 ! response to lipid
is_a: GO:0046683 ! response to organophosphorus
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: sl
creation_date: 2015-08-19T15:36:48Z

[Term]
id: GO:1904566
name: cellular response to 1-oleoyl-sn-glycerol 3-phosphate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-oleoyl-sn-glycerol 3-phosphate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:12139919]
synonym: "cellular response to 1-oleoyl lysophosphatidic acid" EXACT []
synonym: "cellular response to LPA" EXACT []
synonym: "cellular response to lysophosphatidic acid" EXACT []
synonym: "cellular response to oleoyl lysophosphatidic acid" EXACT []
synonym: "cellular response to oleoyl-L-alpha-lysophosphatidic acid" EXACT []
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1904565 ! response to 1-oleoyl-sn-glycerol 3-phosphate
created_by: sl
creation_date: 2015-08-19T15:37:05Z

[Term]
id: GO:1904567
name: response to wortmannin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a wortmannin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20629186]
synonym: "response to wartmannin" EXACT []
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901654 ! response to ketone
created_by: sl
creation_date: 2015-08-19T16:22:28Z

[Term]
id: GO:1904568
name: cellular response to wortmannin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a wortmannin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20629186]
synonym: "cellular response to wartmannin" EXACT []
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901655 ! cellular response to ketone
is_a: GO:1904567 ! response to wortmannin
created_by: sl
creation_date: 2015-08-19T16:22:34Z

[Term]
id: GO:1904569
name: regulation of selenocysteine incorporation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of selenocysteine incorporation." [GO_REF:0000058, GOC:TermGenie, PMID:21685449]
is_a: GO:0006448 ! regulation of translational elongation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001514 ! selenocysteine incorporation
relationship: regulates GO:0001514 ! selenocysteine incorporation
created_by: sl
creation_date: 2015-08-19T17:26:38Z

[Term]
id: GO:1904570
name: negative regulation of selenocysteine incorporation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of selenocysteine incorporation." [GO_REF:0000058, GOC:TermGenie, PMID:21685449]
synonym: "down regulation of selenocysteine incorporation" EXACT [GOC:TermGenie]
synonym: "down-regulation of selenocysteine incorporation" EXACT [GOC:TermGenie]
synonym: "downregulation of selenocysteine incorporation" EXACT [GOC:TermGenie]
synonym: "inhibition of selenocysteine incorporation" NARROW [GOC:TermGenie]
is_a: GO:0045900 ! negative regulation of translational elongation
is_a: GO:1904569 ! regulation of selenocysteine incorporation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001514 ! selenocysteine incorporation
relationship: negatively_regulates GO:0001514 ! selenocysteine incorporation
created_by: sl
creation_date: 2015-08-19T17:26:44Z

[Term]
id: GO:1904571
name: positive regulation of selenocysteine incorporation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of selenocysteine incorporation." [GO_REF:0000058, GOC:TermGenie, PMID:21685449]
synonym: "activation of selenocysteine incorporation" NARROW [GOC:TermGenie]
synonym: "up regulation of selenocysteine incorporation" EXACT [GOC:TermGenie]
synonym: "up-regulation of selenocysteine incorporation" EXACT [GOC:TermGenie]
synonym: "upregulation of selenocysteine incorporation" EXACT [GOC:TermGenie]
is_a: GO:0045901 ! positive regulation of translational elongation
is_a: GO:1904569 ! regulation of selenocysteine incorporation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001514 ! selenocysteine incorporation
relationship: positively_regulates GO:0001514 ! selenocysteine incorporation
created_by: sl
creation_date: 2015-08-19T17:26:50Z

[Term]
id: GO:1904572
name: negative regulation of mRNA binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA binding." [GO_REF:0000059, GOC:TermGenie, PMID:19716792]
synonym: "down regulation of mRNA binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of mRNA binding" EXACT [GOC:TermGenie]
synonym: "downregulation of mRNA binding" EXACT [GOC:TermGenie]
synonym: "inhibition of mRNA binding" NARROW [GOC:TermGenie]
is_a: GO:0051100 ! negative regulation of binding
is_a: GO:1902415 ! regulation of mRNA binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003729 ! mRNA binding
relationship: negatively_regulates GO:0003729 ! mRNA binding
created_by: sl
creation_date: 2015-08-19T17:51:03Z

[Term]
id: GO:1904573
name: regulation of selenocysteine insertion sequence binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of selenocysteine insertion sequence binding." [GO_REF:0000059, GOC:TermGenie, PMID:19716792]
synonym: "regulation of SECIS binding" EXACT [GOC:TermGenie]
is_a: GO:1902415 ! regulation of mRNA binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035368 ! selenocysteine insertion sequence binding
relationship: regulates GO:0035368 ! selenocysteine insertion sequence binding
created_by: sl
creation_date: 2015-08-19T17:51:09Z

[Term]
id: GO:1904574
name: negative regulation of selenocysteine insertion sequence binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of selenocysteine insertion sequence binding." [GO_REF:0000059, GOC:TermGenie, PMID:19716792]
synonym: "down regulation of SECIS binding" EXACT [GOC:TermGenie]
synonym: "down regulation of selenocysteine insertion sequence binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of SECIS binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of selenocysteine insertion sequence binding" EXACT [GOC:TermGenie]
synonym: "downregulation of SECIS binding" EXACT [GOC:TermGenie]
synonym: "downregulation of selenocysteine insertion sequence binding" EXACT [GOC:TermGenie]
synonym: "inhibition of SECIS binding" NARROW [GOC:TermGenie]
synonym: "inhibition of selenocysteine insertion sequence binding" NARROW [GOC:TermGenie]
synonym: "negative regulation of SECIS binding" EXACT [GOC:TermGenie]
is_a: GO:1904572 ! negative regulation of mRNA binding
is_a: GO:1904573 ! regulation of selenocysteine insertion sequence binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035368 ! selenocysteine insertion sequence binding
relationship: negatively_regulates GO:0035368 ! selenocysteine insertion sequence binding
created_by: sl
creation_date: 2015-08-19T17:51:15Z

[Term]
id: GO:1904575
name: positive regulation of selenocysteine insertion sequence binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of selenocysteine insertion sequence binding." [GO_REF:0000059, GOC:TermGenie, PMID:19716792]
synonym: "activation of SECIS binding" NARROW [GOC:TermGenie]
synonym: "activation of selenocysteine insertion sequence binding" NARROW [GOC:TermGenie]
synonym: "positive regulation of SECIS binding" EXACT [GOC:TermGenie]
synonym: "up regulation of SECIS binding" EXACT [GOC:TermGenie]
synonym: "up regulation of selenocysteine insertion sequence binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of SECIS binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of selenocysteine insertion sequence binding" EXACT [GOC:TermGenie]
synonym: "upregulation of SECIS binding" EXACT [GOC:TermGenie]
synonym: "upregulation of selenocysteine insertion sequence binding" EXACT [GOC:TermGenie]
is_a: GO:1902416 ! positive regulation of mRNA binding
is_a: GO:1904573 ! regulation of selenocysteine insertion sequence binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035368 ! selenocysteine insertion sequence binding
relationship: positively_regulates GO:0035368 ! selenocysteine insertion sequence binding
created_by: sl
creation_date: 2015-08-19T17:51:21Z

[Term]
id: GO:1904576
name: response to tunicamycin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tunicamycin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23106379]
is_a: GO:0042221 ! response to chemical
created_by: sl
creation_date: 2015-08-19T18:01:52Z

[Term]
id: GO:1904577
name: cellular response to tunicamycin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tunicamycin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23106379]
is_a: GO:0070887 ! cellular response to chemical stimulus
is_a: GO:1904576 ! response to tunicamycin
created_by: sl
creation_date: 2015-08-19T18:01:58Z

[Term]
id: GO:1904578
name: response to thapsigargin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thapsigargin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23106379]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033993 ! response to lipid
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: sl
creation_date: 2015-08-19T18:06:22Z

[Term]
id: GO:1904579
name: cellular response to thapsigargin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thapsigargin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23106379]
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1904578 ! response to thapsigargin
created_by: sl
creation_date: 2015-08-19T18:06:28Z

[Term]
id: GO:1904580
name: regulation of intracellular mRNA localization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of intracellular mRNA localization." [GO_REF:0000058, GOC:TermGenie, PMID:21471000]
synonym: "regulation of establishment and maintenance of intracellular RNA localization" EXACT [GOC:TermGenie]
synonym: "regulation of intracellular mRNA localisation" EXACT [GOC:TermGenie]
synonym: "regulation of intracellular mRNA positioning" NARROW [GOC:TermGenie]
synonym: "regulation of mRNA localization, intracellular" EXACT [GOC:TermGenie]
synonym: "regulation of mRNA positioning, intracellular" NARROW [GOC:TermGenie]
is_a: GO:0060341 ! regulation of cellular localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008298 ! intracellular mRNA localization
relationship: regulates GO:0008298 ! intracellular mRNA localization
created_by: sl
creation_date: 2015-08-19T23:40:25Z

[Term]
id: GO:1904581
name: negative regulation of intracellular mRNA localization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of intracellular mRNA localization." [GO_REF:0000058, GOC:TermGenie, PMID:21471000]
synonym: "down regulation of establishment and maintenance of intracellular RNA localization" EXACT [GOC:TermGenie]
synonym: "down regulation of intracellular mRNA localisation" EXACT [GOC:TermGenie]
synonym: "down regulation of intracellular mRNA localization" EXACT [GOC:TermGenie]
synonym: "down regulation of intracellular mRNA positioning" NARROW [GOC:TermGenie]
synonym: "down regulation of mRNA localization, intracellular" EXACT [GOC:TermGenie]
synonym: "down regulation of mRNA positioning, intracellular" NARROW [GOC:TermGenie]
synonym: "down-regulation of establishment and maintenance of intracellular RNA localization" EXACT [GOC:TermGenie]
synonym: "down-regulation of intracellular mRNA localisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of intracellular mRNA localization" EXACT [GOC:TermGenie]
synonym: "down-regulation of intracellular mRNA positioning" NARROW [GOC:TermGenie]
synonym: "down-regulation of mRNA localization, intracellular" EXACT [GOC:TermGenie]
synonym: "down-regulation of mRNA positioning, intracellular" NARROW [GOC:TermGenie]
synonym: "downregulation of establishment and maintenance of intracellular RNA localization" EXACT [GOC:TermGenie]
synonym: "downregulation of intracellular mRNA localisation" EXACT [GOC:TermGenie]
synonym: "downregulation of intracellular mRNA localization" EXACT [GOC:TermGenie]
synonym: "downregulation of intracellular mRNA positioning" NARROW [GOC:TermGenie]
synonym: "downregulation of mRNA localization, intracellular" EXACT [GOC:TermGenie]
synonym: "downregulation of mRNA positioning, intracellular" NARROW [GOC:TermGenie]
synonym: "inhibition of establishment and maintenance of intracellular RNA localization" NARROW [GOC:TermGenie]
synonym: "inhibition of intracellular mRNA localisation" NARROW [GOC:TermGenie]
synonym: "inhibition of intracellular mRNA localization" NARROW [GOC:TermGenie]
synonym: "inhibition of intracellular mRNA positioning" NARROW [GOC:TermGenie]
synonym: "inhibition of mRNA localization, intracellular" NARROW [GOC:TermGenie]
synonym: "inhibition of mRNA positioning, intracellular" NARROW [GOC:TermGenie]
synonym: "negative regulation of establishment and maintenance of intracellular RNA localization" EXACT [GOC:TermGenie]
synonym: "negative regulation of intracellular mRNA localisation" EXACT [GOC:TermGenie]
synonym: "negative regulation of intracellular mRNA positioning" NARROW [GOC:TermGenie]
synonym: "negative regulation of mRNA localization, intracellular" EXACT [GOC:TermGenie]
synonym: "negative regulation of mRNA positioning, intracellular" NARROW [GOC:TermGenie]
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:1904580 ! regulation of intracellular mRNA localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008298 ! intracellular mRNA localization
relationship: negatively_regulates GO:0008298 ! intracellular mRNA localization
created_by: sl
creation_date: 2015-08-19T23:40:32Z

[Term]
id: GO:1904582
name: positive regulation of intracellular mRNA localization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of intracellular mRNA localization." [GO_REF:0000058, GOC:TermGenie, PMID:21471000]
synonym: "activation of establishment and maintenance of intracellular RNA localization" NARROW [GOC:TermGenie]
synonym: "activation of intracellular mRNA localisation" NARROW [GOC:TermGenie]
synonym: "activation of intracellular mRNA localization" NARROW [GOC:TermGenie]
synonym: "activation of intracellular mRNA positioning" NARROW [GOC:TermGenie]
synonym: "activation of mRNA localization, intracellular" NARROW [GOC:TermGenie]
synonym: "activation of mRNA positioning, intracellular" NARROW [GOC:TermGenie]
synonym: "positive regulation of establishment and maintenance of intracellular RNA localization" EXACT [GOC:TermGenie]
synonym: "positive regulation of intracellular mRNA localisation" EXACT [GOC:TermGenie]
synonym: "positive regulation of intracellular mRNA positioning" NARROW [GOC:TermGenie]
synonym: "positive regulation of mRNA localization, intracellular" EXACT [GOC:TermGenie]
synonym: "positive regulation of mRNA positioning, intracellular" NARROW [GOC:TermGenie]
synonym: "up regulation of establishment and maintenance of intracellular RNA localization" EXACT [GOC:TermGenie]
synonym: "up regulation of intracellular mRNA localisation" EXACT [GOC:TermGenie]
synonym: "up regulation of intracellular mRNA localization" EXACT [GOC:TermGenie]
synonym: "up regulation of intracellular mRNA positioning" NARROW [GOC:TermGenie]
synonym: "up regulation of mRNA localization, intracellular" EXACT [GOC:TermGenie]
synonym: "up regulation of mRNA positioning, intracellular" NARROW [GOC:TermGenie]
synonym: "up-regulation of establishment and maintenance of intracellular RNA localization" EXACT [GOC:TermGenie]
synonym: "up-regulation of intracellular mRNA localisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of intracellular mRNA localization" EXACT [GOC:TermGenie]
synonym: "up-regulation of intracellular mRNA positioning" NARROW [GOC:TermGenie]
synonym: "up-regulation of mRNA localization, intracellular" EXACT [GOC:TermGenie]
synonym: "up-regulation of mRNA positioning, intracellular" NARROW [GOC:TermGenie]
synonym: "upregulation of establishment and maintenance of intracellular RNA localization" EXACT [GOC:TermGenie]
synonym: "upregulation of intracellular mRNA localisation" EXACT [GOC:TermGenie]
synonym: "upregulation of intracellular mRNA localization" EXACT [GOC:TermGenie]
synonym: "upregulation of intracellular mRNA positioning" NARROW [GOC:TermGenie]
synonym: "upregulation of mRNA localization, intracellular" EXACT [GOC:TermGenie]
synonym: "upregulation of mRNA positioning, intracellular" NARROW [GOC:TermGenie]
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:1904580 ! regulation of intracellular mRNA localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008298 ! intracellular mRNA localization
relationship: positively_regulates GO:0008298 ! intracellular mRNA localization
created_by: sl
creation_date: 2015-08-19T23:40:38Z

[Term]
id: GO:1904583
name: response to polyamine macromolecule
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a polyamine macromolecule stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20805360]
synonym: "response to polyamine" EXACT []
synonym: "response to polyamines" EXACT []
is_a: GO:0010243 ! response to organonitrogen compound
created_by: sl
creation_date: 2015-08-20T14:35:26Z

[Term]
id: GO:1904584
name: cellular response to polyamine macromolecule
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a polyamine macromolecule stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20805360]
synonym: "cellular response to polyamine" EXACT []
synonym: "cellular response to polyamines" EXACT []
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:1904583 ! response to polyamine macromolecule
created_by: sl
creation_date: 2015-08-20T14:35:32Z

[Term]
id: GO:1904585
name: response to putrescine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a putrescine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20805360]
synonym: "response to 1,4-Butanediamine" EXACT []
synonym: "response to 1,4-Diaminobutane" EXACT []
synonym: "response to tetramethylenediamine" EXACT []
is_a: GO:0010243 ! response to organonitrogen compound
created_by: sl
creation_date: 2015-08-20T14:35:39Z

[Term]
id: GO:1904586
name: cellular response to putrescine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a putrescine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20805360]
synonym: "cellular response to 1,4-Butanediamine" EXACT []
synonym: "cellular response to 1,4-Diaminobutane" EXACT []
synonym: "cellular response to tetramethylenediamine" EXACT []
is_a: GO:0071242 ! cellular response to ammonium ion
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:1904585 ! response to putrescine
created_by: sl
creation_date: 2015-08-20T14:35:45Z

[Term]
id: GO:1904587
name: response to glycoprotein
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoprotein stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:14597422]
synonym: "response to glycoproteins" EXACT []
is_a: GO:0010033 ! response to organic substance
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: sl
creation_date: 2015-08-20T16:46:24Z

[Term]
id: GO:1904588
name: cellular response to glycoprotein
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoprotein stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:14597422]
synonym: "cellular response to glycoproteins" EXACT []
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1904587 ! response to glycoprotein
created_by: sl
creation_date: 2015-08-20T16:46:30Z

[Term]
id: GO:1904589
name: regulation of protein import
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein import." [GO_REF:0000058, GOC:TermGenie, PMID:11406629]
synonym: "regulation of protein uptake" EXACT [GOC:TermGenie]
is_a: GO:0051223 ! regulation of protein transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0017038 ! protein import
relationship: regulates GO:0017038 ! protein import
created_by: sl
creation_date: 2015-08-20T21:26:30Z

[Term]
id: GO:1904590
name: negative regulation of protein import
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein import." [GO_REF:0000058, GOC:TermGenie, PMID:11406629]
synonym: "down regulation of protein import" EXACT [GOC:TermGenie]
synonym: "down regulation of protein uptake" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein import" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein uptake" EXACT [GOC:TermGenie]
synonym: "downregulation of protein import" EXACT [GOC:TermGenie]
synonym: "downregulation of protein uptake" EXACT [GOC:TermGenie]
synonym: "inhibition of protein import" NARROW [GOC:TermGenie]
synonym: "inhibition of protein uptake" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein uptake" EXACT [GOC:TermGenie]
is_a: GO:0051224 ! negative regulation of protein transport
is_a: GO:1904589 ! regulation of protein import
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0017038 ! protein import
relationship: negatively_regulates GO:0017038 ! protein import
created_by: sl
creation_date: 2015-08-20T21:26:36Z

[Term]
id: GO:1904591
name: positive regulation of protein import
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein import." [GO_REF:0000058, GOC:TermGenie, PMID:11406629]
synonym: "activation of protein import" NARROW [GOC:TermGenie]
synonym: "activation of protein uptake" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein uptake" EXACT [GOC:TermGenie]
synonym: "up regulation of protein import" EXACT [GOC:TermGenie]
synonym: "up regulation of protein uptake" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein import" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein uptake" EXACT [GOC:TermGenie]
synonym: "upregulation of protein import" EXACT [GOC:TermGenie]
synonym: "upregulation of protein uptake" EXACT [GOC:TermGenie]
is_a: GO:0051222 ! positive regulation of protein transport
is_a: GO:1904589 ! regulation of protein import
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0017038 ! protein import
relationship: positively_regulates GO:0017038 ! protein import
created_by: sl
creation_date: 2015-08-20T21:26:42Z

[Term]
id: GO:1904592
name: positive regulation of protein refolding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein refolding." [GO_REF:0000058, GOC:TermGenie, PMID:11360998]
synonym: "activation of heat shock protein activity" RELATED [GOC:TermGenie]
synonym: "activation of protein refolding" NARROW [GOC:TermGenie]
synonym: "positive regulation of heat shock protein activity" RELATED [GOC:TermGenie]
synonym: "up regulation of heat shock protein activity" RELATED [GOC:TermGenie]
synonym: "up regulation of protein refolding" EXACT [GOC:TermGenie]
synonym: "up-regulation of heat shock protein activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of protein refolding" EXACT [GOC:TermGenie]
synonym: "upregulation of heat shock protein activity" RELATED [GOC:TermGenie]
synonym: "upregulation of protein refolding" EXACT [GOC:TermGenie]
is_a: GO:0061083 ! regulation of protein refolding
is_a: GO:1903334 ! positive regulation of protein folding
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042026 ! protein refolding
relationship: positively_regulates GO:0042026 ! protein refolding
created_by: sl
creation_date: 2015-08-21T18:11:16Z

[Term]
id: GO:1904593
name: prostaglandin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with prostaglandin." [GO_REF:0000067, GOC:TermGenie, PMID:21445266]
is_a: GO:0005504 ! fatty acid binding
is_a: GO:0050542 ! icosanoid binding
created_by: sl
creation_date: 2015-08-21T18:53:31Z

[Term]
id: GO:1904594
name: regulation of termination of RNA polymerase II transcription
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of termination of RNA polymerase II transcription." [GO_REF:0000058, GOC:TermGenie, PMID:25417108]
synonym: "regulation of RNA 3'-end formation by RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "regulation of RNA polymerase II transcription termination" EXACT [GOC:TermGenie]
synonym: "regulation of RNA polymerase II transcription termination factor activity" RELATED [GOC:TermGenie]
synonym: "regulation of transcription termination from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "regulation of transcription termination from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0031554 ! regulation of DNA-templated transcription, termination
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006369 ! termination of RNA polymerase II transcription
relationship: regulates GO:0006369 ! termination of RNA polymerase II transcription
created_by: al
creation_date: 2015-08-25T08:56:06Z

[Term]
id: GO:1904595
name: positive regulation of termination of RNA polymerase II transcription
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of termination of RNA polymerase II transcription." [GO_REF:0000058, GOC:TermGenie, PMID:25417108]
synonym: "activation of RNA 3'-end formation by RNA polymerase II" NARROW [GOC:TermGenie]
synonym: "activation of RNA polymerase II transcription termination" NARROW [GOC:TermGenie]
synonym: "activation of RNA polymerase II transcription termination factor activity" RELATED [GOC:TermGenie]
synonym: "activation of termination of RNA polymerase II transcription" NARROW [GOC:TermGenie]
synonym: "activation of transcription termination from Pol II promoter" NARROW [GOC:TermGenie]
synonym: "activation of transcription termination from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "positive regulation of RNA 3'-end formation by RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "positive regulation of RNA polymerase II transcription termination" EXACT [GOC:TermGenie]
synonym: "positive regulation of RNA polymerase II transcription termination factor activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of transcription termination from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription termination from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of RNA 3'-end formation by RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "up regulation of RNA polymerase II transcription termination" EXACT [GOC:TermGenie]
synonym: "up regulation of RNA polymerase II transcription termination factor activity" RELATED [GOC:TermGenie]
synonym: "up regulation of termination of RNA polymerase II transcription" EXACT [GOC:TermGenie]
synonym: "up regulation of transcription termination from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "up regulation of transcription termination from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNA 3'-end formation by RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNA polymerase II transcription termination" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNA polymerase II transcription termination factor activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of termination of RNA polymerase II transcription" EXACT [GOC:TermGenie]
synonym: "up-regulation of transcription termination from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "up-regulation of transcription termination from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA 3'-end formation by RNA polymerase II" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA polymerase II transcription termination" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA polymerase II transcription termination factor activity" RELATED [GOC:TermGenie]
synonym: "upregulation of termination of RNA polymerase II transcription" EXACT [GOC:TermGenie]
synonym: "upregulation of transcription termination from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "upregulation of transcription termination from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
is_a: GO:0060566 ! positive regulation of DNA-templated transcription, termination
is_a: GO:1904594 ! regulation of termination of RNA polymerase II transcription
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006369 ! termination of RNA polymerase II transcription
relationship: positively_regulates GO:0006369 ! termination of RNA polymerase II transcription
created_by: al
creation_date: 2015-08-25T08:56:14Z

[Term]
id: GO:1904596
name: regulation of connective tissue replacement involved in inflammatory response wound healing
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of connective tissue replacement involved in inflammatory response wound healing." [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:18245812]
synonym: "regulation of connective tissue replacement during inflammatory response" RELATED [GOC:TermGenie]
synonym: "regulation of fibrosis during inflammatory response" NARROW [GOC:TermGenie]
is_a: GO:0034103 ! regulation of tissue remodeling
is_a: GO:0050727 ! regulation of inflammatory response
is_a: GO:0061041 ! regulation of wound healing
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002248 ! connective tissue replacement involved in inflammatory response wound healing
relationship: regulates GO:0002248 ! connective tissue replacement involved in inflammatory response wound healing
created_by: krc
creation_date: 2015-08-25T20:52:24Z

[Term]
id: GO:1904597
name: negative regulation of connective tissue replacement involved in inflammatory response wound healing
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of connective tissue replacement involved in inflammatory response wound healing." [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:18245812]
synonym: "down regulation of connective tissue replacement during inflammatory response" RELATED [GOC:TermGenie]
synonym: "down regulation of connective tissue replacement involved in inflammatory response wound healing" EXACT [GOC:TermGenie]
synonym: "down regulation of fibrosis during inflammatory response" NARROW [GOC:TermGenie]
synonym: "down-regulation of connective tissue replacement during inflammatory response" RELATED [GOC:TermGenie]
synonym: "down-regulation of connective tissue replacement involved in inflammatory response wound healing" EXACT [GOC:TermGenie]
synonym: "down-regulation of fibrosis during inflammatory response" NARROW [GOC:TermGenie]
synonym: "downregulation of connective tissue replacement during inflammatory response" RELATED [GOC:TermGenie]
synonym: "downregulation of connective tissue replacement involved in inflammatory response wound healing" EXACT [GOC:TermGenie]
synonym: "downregulation of fibrosis during inflammatory response" NARROW [GOC:TermGenie]
synonym: "inhibition of connective tissue replacement during inflammatory response" RELATED [GOC:TermGenie]
synonym: "inhibition of connective tissue replacement involved in inflammatory response wound healing" NARROW [GOC:TermGenie]
synonym: "inhibition of fibrosis during inflammatory response" NARROW [GOC:TermGenie]
synonym: "negative regulation of connective tissue replacement during inflammatory response" RELATED [GOC:TermGenie]
synonym: "negative regulation of fibrosis during inflammatory response" NARROW [GOC:TermGenie]
is_a: GO:0034104 ! negative regulation of tissue remodeling
is_a: GO:0050728 ! negative regulation of inflammatory response
is_a: GO:0061045 ! negative regulation of wound healing
is_a: GO:1904596 ! regulation of connective tissue replacement involved in inflammatory response wound healing
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002248 ! connective tissue replacement involved in inflammatory response wound healing
relationship: negatively_regulates GO:0002248 ! connective tissue replacement involved in inflammatory response wound healing
created_by: krc
creation_date: 2015-08-25T20:52:30Z

[Term]
id: GO:1904598
name: positive regulation of connective tissue replacement involved in inflammatory response wound healing
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of connective tissue replacement involved in inflammatory response wound healing." [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:18245812]
synonym: "activation of connective tissue replacement during inflammatory response" RELATED [GOC:TermGenie]
synonym: "activation of connective tissue replacement involved in inflammatory response wound healing" NARROW [GOC:TermGenie]
synonym: "activation of fibrosis during inflammatory response" NARROW [GOC:TermGenie]
synonym: "positive regulation of connective tissue replacement during inflammatory response" RELATED [GOC:TermGenie]
synonym: "positive regulation of fibrosis during inflammatory response" NARROW [GOC:TermGenie]
synonym: "up regulation of connective tissue replacement during inflammatory response" RELATED [GOC:TermGenie]
synonym: "up regulation of connective tissue replacement involved in inflammatory response wound healing" EXACT [GOC:TermGenie]
synonym: "up regulation of fibrosis during inflammatory response" NARROW [GOC:TermGenie]
synonym: "up-regulation of connective tissue replacement during inflammatory response" RELATED [GOC:TermGenie]
synonym: "up-regulation of connective tissue replacement involved in inflammatory response wound healing" EXACT [GOC:TermGenie]
synonym: "up-regulation of fibrosis during inflammatory response" NARROW [GOC:TermGenie]
synonym: "upregulation of connective tissue replacement during inflammatory response" RELATED [GOC:TermGenie]
synonym: "upregulation of connective tissue replacement involved in inflammatory response wound healing" EXACT [GOC:TermGenie]
synonym: "upregulation of fibrosis during inflammatory response" NARROW [GOC:TermGenie]
is_a: GO:0034105 ! positive regulation of tissue remodeling
is_a: GO:0050729 ! positive regulation of inflammatory response
is_a: GO:0090303 ! positive regulation of wound healing
is_a: GO:1904596 ! regulation of connective tissue replacement involved in inflammatory response wound healing
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002248 ! connective tissue replacement involved in inflammatory response wound healing
relationship: positively_regulates GO:0002248 ! connective tissue replacement involved in inflammatory response wound healing
created_by: krc
creation_date: 2015-08-25T20:52:36Z

[Term]
id: GO:1904599
name: advanced glycation end-product binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with advanced glycation end-product." [GO_REF:0000067, GOC:krc, GOC:TermGenie, PMID:1650387]
is_a: GO:0097367 ! carbohydrate derivative binding
created_by: krc
creation_date: 2015-08-25T23:39:32Z

[Term]
id: GO:1904600
name: actin fusion focus assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an actin fusion focus." [GO_REF:0000079, GOC:TermGenie, PMID:25825517]
synonym: "actin fusion focus formation" EXACT [GOC:TermGenie]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0030036 ! actin cytoskeleton organization
created_by: al
creation_date: 2015-08-26T10:34:48Z

[Term]
id: GO:1904601
name: protein localization to actin fusion focus
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within an actin fusion focus." [GO_REF:0000087, GOC:TermGenie, PMID:25825517]
synonym: "protein localisation in actin fusion focus" EXACT [GOC:TermGenie]
synonym: "protein localisation to actin fusion focus" EXACT [GOC:TermGenie]
synonym: "protein localization in actin fusion focus" EXACT [GOC:TermGenie]
is_a: GO:1903119 ! protein localization to actin cytoskeleton
is_a: GO:1903260 ! protein localization to mating projection tip
created_by: al
creation_date: 2015-08-26T10:36:22Z

[Term]
id: GO:1904602
name: serotonin-activated cation-selective channel complex
namespace: cellular_component
def: "A protein complex which is capable of serotonin-activated cation-selective channel activity. Mainly found in pre- and postsynaptic membranes of the brain and gastrointestinal tract. Depending on its location it transports Ca2+, Mg2+, Na+ or K+. It is always a pentamer, containing at least the 5HT3A subunit forming 5HT3A homopentamers or 5HT3A/B heteropentamers. In human, 5HT3A/C, A/D and A/E heteropentamers also exist." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:16116092]
comment: An example of this is HTR3A in human (P46098) in PMID:16116092 (inferred from direct assay).
synonym: "5-HT-3 receptor complex" EXACT []
synonym: "5-HT3 receptor complex" EXACT []
synonym: "5-hydroxytryptamine receptor 3 complex" EXACT []
synonym: "5HT3 receptor complex" EXACT []
synonym: "serotonin receptor complex" BROAD []
is_a: GO:0034703 ! cation channel complex
is_a: GO:0043235 ! receptor complex
created_by: bhm
creation_date: 2015-08-26T13:19:49Z

[Term]
id: GO:1904603
name: regulation of advanced glycation end-product receptor activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of advanced glycation end-product receptor activity." [GO_REF:0000059, GOC:krc, GOC:TermGenie, PMID:16503878]
synonym: "regulation of AGE receptor activity" EXACT [GOC:TermGenie]
synonym: "regulation of RAGE activity" EXACT [GOC:TermGenie]
is_a: GO:0010469 ! regulation of receptor activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050785 ! advanced glycation end-product receptor activity
relationship: regulates GO:0050785 ! advanced glycation end-product receptor activity
created_by: krc
creation_date: 2015-08-26T16:24:49Z

[Term]
id: GO:1904604
name: negative regulation of advanced glycation end-product receptor activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of advanced glycation end-product receptor activity." [GO_REF:0000059, GOC:krc, GOC:TermGenie, PMID:16503878]
synonym: "down regulation of advanced glycation end-product receptor activity" EXACT [GOC:TermGenie]
synonym: "down regulation of AGE receptor activity" EXACT [GOC:TermGenie]
synonym: "down regulation of RAGE activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of advanced glycation end-product receptor activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of AGE receptor activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of RAGE activity" EXACT [GOC:TermGenie]
synonym: "downregulation of advanced glycation end-product receptor activity" EXACT [GOC:TermGenie]
synonym: "downregulation of AGE receptor activity" EXACT [GOC:TermGenie]
synonym: "downregulation of RAGE activity" EXACT [GOC:TermGenie]
synonym: "inhibition of advanced glycation end-product receptor activity" NARROW [GOC:TermGenie]
synonym: "inhibition of AGE receptor activity" NARROW [GOC:TermGenie]
synonym: "inhibition of RAGE activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of AGE receptor activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of RAGE activity" EXACT [GOC:TermGenie]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:1904603 ! regulation of advanced glycation end-product receptor activity
is_a: GO:2000272 ! negative regulation of receptor activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0050785 ! advanced glycation end-product receptor activity
relationship: negatively_regulates GO:0050785 ! advanced glycation end-product receptor activity
created_by: krc
creation_date: 2015-08-26T16:24:56Z

[Term]
id: GO:1904605
name: positive regulation of advanced glycation end-product receptor activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of advanced glycation end-product receptor activity." [GO_REF:0000059, GOC:krc, GOC:TermGenie, PMID:16503878]
synonym: "activation of advanced glycation end-product receptor activity" NARROW [GOC:TermGenie]
synonym: "activation of AGE receptor activity" NARROW [GOC:TermGenie]
synonym: "activation of RAGE activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of AGE receptor activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of RAGE activity" EXACT [GOC:TermGenie]
synonym: "up regulation of advanced glycation end-product receptor activity" EXACT [GOC:TermGenie]
synonym: "up regulation of AGE receptor activity" EXACT [GOC:TermGenie]
synonym: "up regulation of RAGE activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of advanced glycation end-product receptor activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of AGE receptor activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of RAGE activity" EXACT [GOC:TermGenie]
synonym: "upregulation of advanced glycation end-product receptor activity" EXACT [GOC:TermGenie]
synonym: "upregulation of AGE receptor activity" EXACT [GOC:TermGenie]
synonym: "upregulation of RAGE activity" EXACT [GOC:TermGenie]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:1904603 ! regulation of advanced glycation end-product receptor activity
is_a: GO:2000273 ! positive regulation of receptor activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0050785 ! advanced glycation end-product receptor activity
relationship: positively_regulates GO:0050785 ! advanced glycation end-product receptor activity
created_by: krc
creation_date: 2015-08-26T16:25:02Z

[Term]
id: GO:1904606
name: fat cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a fat cell." [GO_REF:0000085, GOC:TermGenie, PMID:17024416]
synonym: "adipocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "adipocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "adipose cell apoptosis" NARROW [GOC:TermGenie]
synonym: "adipose cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "fat cell apoptosis" NARROW [GOC:TermGenie]
is_a: GO:0006915 ! apoptotic process
created_by: sl
creation_date: 2015-08-27T18:13:06Z

[Term]
id: GO:1904608
name: response to monosodium L-glutamate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosodium L-glutamate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21389115]
is_a: GO:1904008 ! response to monosodium glutamate
created_by: sl
creation_date: 2015-08-27T18:43:08Z

[Term]
id: GO:1904609
name: cellular response to monosodium L-glutamate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosodium L-glutamate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21389115]
is_a: GO:1904009 ! cellular response to monosodium glutamate
is_a: GO:1904608 ! response to monosodium L-glutamate
created_by: sl
creation_date: 2015-08-27T18:43:14Z

[Term]
id: GO:1904610
name: response to 3,3',4,4',5-pentachlorobiphenyl
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 3,3',4,4',5-pentachlorobiphenyl stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23196670]
synonym: "response to PCB 126" EXACT []
is_a: GO:0014070 ! response to organic cyclic compound
created_by: sl
creation_date: 2015-08-27T18:52:49Z

[Term]
id: GO:1904611
name: cellular response to 3,3',4,4',5-pentachlorobiphenyl
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 3,3',4,4',5-pentachlorobiphenyl stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23196670]
synonym: "cellular response to PCB 126" EXACT []
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1904610 ! response to 3,3',4,4',5-pentachlorobiphenyl
created_by: sl
creation_date: 2015-08-27T18:52:55Z

[Term]
id: GO:1904612
name: response to 2,3,7,8-tetrachlorodibenzodioxine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 2,3,7,8-tetrachlorodibenzodioxine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23196670]
synonym: "response to dioxin" EXACT []
synonym: "response to TCDD" EXACT []
is_a: GO:0014070 ! response to organic cyclic compound
created_by: sl
creation_date: 2015-08-27T19:01:52Z

[Term]
id: GO:1904613
name: cellular response to 2,3,7,8-tetrachlorodibenzodioxine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 2,3,7,8-tetrachlorodibenzodioxine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23196670]
synonym: "cellular response to dioxin" EXACT []
synonym: "cellular response to TCDD" EXACT []
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1904612 ! response to 2,3,7,8-tetrachlorodibenzodioxine
created_by: sl
creation_date: 2015-08-27T19:01:58Z

[Term]
id: GO:1904614
name: response to biphenyl
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biphenyl stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23196670]
is_a: GO:0014070 ! response to organic cyclic compound
created_by: sl
creation_date: 2015-08-27T19:08:43Z

[Term]
id: GO:1904615
name: cellular response to biphenyl
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biphenyl stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23196670]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1904614 ! response to biphenyl
created_by: sl
creation_date: 2015-08-27T19:08:49Z

[Term]
id: GO:1904616
name: regulation of actin binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of actin binding." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:8621557]
synonym: "regulation of membrane associated actin binding" NARROW [GOC:TermGenie]
is_a: GO:0043393 ! regulation of protein binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003779 ! actin binding
relationship: regulates GO:0003779 ! actin binding
created_by: mr
creation_date: 2015-08-27T19:08:56Z

[Term]
id: GO:1904617
name: negative regulation of actin binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of actin binding." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:8621557]
synonym: "down regulation of actin binding" EXACT [GOC:TermGenie]
synonym: "down regulation of membrane associated actin binding" NARROW [GOC:TermGenie]
synonym: "down-regulation of actin binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of membrane associated actin binding" NARROW [GOC:TermGenie]
synonym: "downregulation of actin binding" EXACT [GOC:TermGenie]
synonym: "downregulation of membrane associated actin binding" NARROW [GOC:TermGenie]
synonym: "inhibition of actin binding" NARROW [GOC:TermGenie]
synonym: "inhibition of membrane associated actin binding" NARROW [GOC:TermGenie]
synonym: "negative regulation of membrane associated actin binding" NARROW [GOC:TermGenie]
is_a: GO:0032091 ! negative regulation of protein binding
is_a: GO:1904616 ! regulation of actin binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003779 ! actin binding
relationship: negatively_regulates GO:0003779 ! actin binding
created_by: mr
creation_date: 2015-08-27T19:09:02Z

[Term]
id: GO:1904618
name: positive regulation of actin binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of actin binding." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:8621557]
synonym: "activation of actin binding" NARROW [GOC:TermGenie]
synonym: "activation of membrane associated actin binding" NARROW [GOC:TermGenie]
synonym: "positive regulation of membrane associated actin binding" NARROW [GOC:TermGenie]
synonym: "up regulation of actin binding" EXACT [GOC:TermGenie]
synonym: "up regulation of membrane associated actin binding" NARROW [GOC:TermGenie]
synonym: "up-regulation of actin binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of membrane associated actin binding" NARROW [GOC:TermGenie]
synonym: "upregulation of actin binding" EXACT [GOC:TermGenie]
synonym: "upregulation of membrane associated actin binding" NARROW [GOC:TermGenie]
is_a: GO:0032092 ! positive regulation of protein binding
is_a: GO:1904616 ! regulation of actin binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003779 ! actin binding
relationship: positively_regulates GO:0003779 ! actin binding
created_by: mr
creation_date: 2015-08-27T19:09:08Z

[Term]
id: GO:1904619
name: response to dimethyl sulfoxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dimethyl sulfoxide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:12873812]
synonym: "response to DMSO" EXACT []
is_a: GO:0010033 ! response to organic substance
created_by: sl
creation_date: 2015-08-27T19:13:49Z

[Term]
id: GO:1904620
name: cellular response to dimethyl sulfoxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dimethyl sulfoxide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:12873812]
synonym: "cellular response to DMSO" EXACT []
is_a: GO:0070887 ! cellular response to chemical stimulus
is_a: GO:1904619 ! response to dimethyl sulfoxide
created_by: sl
creation_date: 2015-08-27T19:14:07Z

[Term]
id: GO:1904621
name: regulation of actin-dependent ATPase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of actin-dependent ATPase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:8621557]
synonym: "regulation of actin-activated ATPase activity" EXACT [GOC:TermGenie]
is_a: GO:0043462 ! regulation of ATPase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030898 ! actin-dependent ATPase activity
relationship: regulates GO:0030898 ! actin-dependent ATPase activity
created_by: mr
creation_date: 2015-08-27T19:37:18Z

[Term]
id: GO:1904622
name: negative regulation of actin-dependent ATPase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of actin-dependent ATPase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:8621557]
synonym: "down regulation of actin-activated ATPase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of actin-dependent ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of actin-activated ATPase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of actin-dependent ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of actin-activated ATPase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of actin-dependent ATPase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of actin-activated ATPase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of actin-dependent ATPase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of actin-activated ATPase activity" EXACT [GOC:TermGenie]
is_a: GO:0032780 ! negative regulation of ATPase activity
is_a: GO:1904621 ! regulation of actin-dependent ATPase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030898 ! actin-dependent ATPase activity
relationship: negatively_regulates GO:0030898 ! actin-dependent ATPase activity
created_by: mr
creation_date: 2015-08-27T19:37:24Z

[Term]
id: GO:1904623
name: positive regulation of actin-dependent ATPase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of actin-dependent ATPase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:8621557]
synonym: "activation of actin-activated ATPase activity" NARROW [GOC:TermGenie]
synonym: "activation of actin-dependent ATPase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of actin-activated ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of actin-activated ATPase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of actin-dependent ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of actin-activated ATPase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of actin-dependent ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of actin-activated ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of actin-dependent ATPase activity" EXACT [GOC:TermGenie]
is_a: GO:0032781 ! positive regulation of ATPase activity
is_a: GO:1904621 ! regulation of actin-dependent ATPase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030898 ! actin-dependent ATPase activity
relationship: positively_regulates GO:0030898 ! actin-dependent ATPase activity
created_by: mr
creation_date: 2015-08-27T19:37:30Z

[Term]
id: GO:1904624
name: regulation of glycine secretion, neurotransmission
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glycine secretion, neurotransmission." [GO_REF:0000058, GOC:TermGenie, PMID:22988142]
is_a: GO:0046928 ! regulation of neurotransmitter secretion
is_a: GO:0051955 ! regulation of amino acid transport
is_a: GO:0060092 ! regulation of synaptic transmission, glycinergic
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061537 ! glycine secretion, neurotransmission
relationship: regulates GO:0061537 ! glycine secretion, neurotransmission
created_by: hjd
creation_date: 2015-08-27T20:03:38Z

[Term]
id: GO:1904625
name: negative regulation of glycine secretion, neurotransmission
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glycine secretion, neurotransmission." [GO_REF:0000058, GOC:TermGenie, PMID:22988142]
synonym: "down regulation of glycine secretion, neurotransmission" EXACT [GOC:TermGenie]
synonym: "down-regulation of glycine secretion, neurotransmission" EXACT [GOC:TermGenie]
synonym: "downregulation of glycine secretion, neurotransmission" EXACT [GOC:TermGenie]
synonym: "inhibition of glycine secretion, neurotransmission" NARROW [GOC:TermGenie]
is_a: GO:0046929 ! negative regulation of neurotransmitter secretion
is_a: GO:0051956 ! negative regulation of amino acid transport
is_a: GO:0060093 ! negative regulation of synaptic transmission, glycinergic
is_a: GO:1904624 ! regulation of glycine secretion, neurotransmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061537 ! glycine secretion, neurotransmission
relationship: negatively_regulates GO:0061537 ! glycine secretion, neurotransmission
created_by: hjd
creation_date: 2015-08-27T20:03:44Z

[Term]
id: GO:1904626
name: positive regulation of glycine secretion, neurotransmission
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glycine secretion, neurotransmission." [GO_REF:0000058, GOC:TermGenie, PMID:22988142]
synonym: "activation of glycine secretion, neurotransmission" NARROW [GOC:TermGenie]
synonym: "up regulation of glycine secretion, neurotransmission" EXACT [GOC:TermGenie]
synonym: "up-regulation of glycine secretion, neurotransmission" EXACT [GOC:TermGenie]
synonym: "upregulation of glycine secretion, neurotransmission" EXACT [GOC:TermGenie]
is_a: GO:0001956 ! positive regulation of neurotransmitter secretion
is_a: GO:0051957 ! positive regulation of amino acid transport
is_a: GO:0060094 ! positive regulation of synaptic transmission, glycinergic
is_a: GO:1904624 ! regulation of glycine secretion, neurotransmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061537 ! glycine secretion, neurotransmission
relationship: positively_regulates GO:0061537 ! glycine secretion, neurotransmission
created_by: hjd
creation_date: 2015-08-27T20:03:49Z

[Term]
id: GO:1904627
name: response to phorbol 13-acetate 12-myristate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phorbol 13-acetate 12-myristate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:2200903]
synonym: "response to phorbol 12-tetradecanoate 13-acetate" EXACT []
synonym: "response to PMA" EXACT []
synonym: "response to tetradecanoylphorbol acetate" EXACT []
synonym: "response to TPA" EXACT []
is_a: GO:0033993 ! response to lipid
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: sl
creation_date: 2015-08-28T13:44:03Z

[Term]
id: GO:1904628
name: cellular response to phorbol 13-acetate 12-myristate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phorbol 13-acetate 12-myristate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:2200903]
synonym: "cellular response to phorbol 12-tetradecanoate 13-acetate" EXACT []
synonym: "cellular response to response to PMA" EXACT []
synonym: "cellular response to tetradecanoylphorbol acetate" EXACT []
synonym: "cellular response to TPA" EXACT []
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1904627 ! response to phorbol 13-acetate 12-myristate
created_by: sl
creation_date: 2015-08-28T13:44:10Z

[Term]
id: GO:1904629
name: response to diterpene
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diterpene stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:19765580]
is_a: GO:0033993 ! response to lipid
created_by: sl
creation_date: 2015-08-28T13:52:37Z

[Term]
id: GO:1904630
name: cellular response to diterpene
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diterpene stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:19765580]
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:1904629 ! response to diterpene
created_by: sl
creation_date: 2015-08-28T13:52:43Z

[Term]
id: GO:1904631
name: response to glucoside
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucoside stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16842873]
synonym: "response to glucosides" EXACT []
is_a: GO:1903416 ! response to glycoside
created_by: sl
creation_date: 2015-08-28T14:01:31Z

[Term]
id: GO:1904632
name: cellular response to glucoside
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucoside stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16842873]
synonym: "cellular response to glucosides" EXACT []
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1904631 ! response to glucoside
created_by: sl
creation_date: 2015-08-28T14:01:37Z

[Term]
id: GO:1904633
name: regulation of glomerular visceral epithelial cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glomerular visceral epithelial cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:23692924]
synonym: "regulation of glomerular podocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of glomerular podocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "regulation of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of podocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of podocyte apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:1904035 ! regulation of epithelial cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1903210 ! glomerular visceral epithelial cell apoptotic process
relationship: regulates GO:1903210 ! glomerular visceral epithelial cell apoptotic process
created_by: sl
creation_date: 2015-08-28T14:14:44Z

[Term]
id: GO:1904634
name: negative regulation of glomerular visceral epithelial cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glomerular visceral epithelial cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:23692924]
synonym: "down regulation of glomerular podocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of glomerular podocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "down regulation of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of glomerular visceral epithelial cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down regulation of podocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of podocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of glomerular podocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of glomerular podocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of glomerular visceral epithelial cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of podocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of podocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of glomerular podocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of glomerular podocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of glomerular visceral epithelial cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of podocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of podocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "inhibition of glomerular podocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of glomerular podocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "inhibition of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of glomerular visceral epithelial cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "inhibition of podocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of podocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of glomerular podocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of glomerular podocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of podocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of podocyte apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:1904036 ! negative regulation of epithelial cell apoptotic process
is_a: GO:1904633 ! regulation of glomerular visceral epithelial cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1903210 ! glomerular visceral epithelial cell apoptotic process
relationship: negatively_regulates GO:1903210 ! glomerular visceral epithelial cell apoptotic process
created_by: sl
creation_date: 2015-08-28T14:14:50Z

[Term]
id: GO:1904635
name: positive regulation of glomerular visceral epithelial cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glomerular visceral epithelial cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:23692924]
synonym: "activation of glomerular podocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of glomerular podocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "activation of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of glomerular visceral epithelial cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "activation of podocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of podocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of glomerular podocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of glomerular podocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of podocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of podocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of glomerular podocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of glomerular podocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of glomerular visceral epithelial cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of podocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of podocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of glomerular podocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of glomerular podocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of glomerular visceral epithelial cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of podocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of podocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of glomerular podocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of glomerular podocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of glomerular visceral epithelial cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of podocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of podocyte apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:1904037 ! positive regulation of epithelial cell apoptotic process
is_a: GO:1904633 ! regulation of glomerular visceral epithelial cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1903210 ! glomerular visceral epithelial cell apoptotic process
relationship: positively_regulates GO:1903210 ! glomerular visceral epithelial cell apoptotic process
created_by: sl
creation_date: 2015-08-28T14:14:56Z

[Term]
id: GO:1904636
name: response to ionomycin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ionomycin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:17516843]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0045472 ! response to ether
is_a: GO:0070542 ! response to fatty acid
created_by: sl
creation_date: 2015-08-31T14:39:18Z

[Term]
id: GO:1904637
name: cellular response to ionomycin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ionomycin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:17516843]
is_a: GO:0071362 ! cellular response to ether
is_a: GO:0071398 ! cellular response to fatty acid
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1904636 ! response to ionomycin
created_by: sl
creation_date: 2015-08-31T14:39:25Z

[Term]
id: GO:1904638
name: response to resveratrol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a resveratrol stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23555824]
is_a: GO:0035634 ! response to stilbenoid
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: sl
creation_date: 2015-08-31T17:07:38Z

[Term]
id: GO:1904639
name: cellular response to resveratrol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a resveratrol stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23555824]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1904638 ! response to resveratrol
created_by: sl
creation_date: 2015-08-31T17:07:44Z

[Term]
id: GO:1904640
name: response to methionine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methionine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:17716000]
is_a: GO:0043200 ! response to amino acid
created_by: sl
creation_date: 2015-08-31T17:23:56Z

[Term]
id: GO:1904641
name: response to dinitrophenol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dinitrophenol stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24336883]
synonym: "response to dinitrophenols" RELATED []
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: sl
creation_date: 2015-08-31T20:13:12Z

[Term]
id: GO:1904642
name: cellular response to dinitrophenol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dinitrophenol stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24336883]
synonym: "cellular response to dinitrophenols" RELATED []
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1904641 ! response to dinitrophenol
created_by: sl
creation_date: 2015-08-31T20:13:18Z

[Term]
id: GO:1904643
name: response to curcumin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a curcumin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24755072]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0045472 ! response to ether
is_a: GO:1901654 ! response to ketone
created_by: sl
creation_date: 2015-08-31T20:38:11Z

[Term]
id: GO:1904644
name: cellular response to curcumin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a curcumin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24755072]
is_a: GO:0071362 ! cellular response to ether
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901655 ! cellular response to ketone
is_a: GO:1904643 ! response to curcumin
created_by: sl
creation_date: 2015-08-31T20:38:17Z

[Term]
id: GO:1904645
name: response to beta-amyloid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a beta-amyloid stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23555824]
synonym: "response to beta-amyloids" RELATED []
is_a: GO:1901652 ! response to peptide
created_by: sl
creation_date: 2015-08-31T20:44:43Z

[Term]
id: GO:1904646
name: cellular response to beta-amyloid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a beta-amyloid stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23555824]
synonym: "cellular response to beta-amyloids" RELATED []
is_a: GO:1901653 ! cellular response to peptide
is_a: GO:1904645 ! response to beta-amyloid
created_by: sl
creation_date: 2015-08-31T20:44:49Z

[Term]
id: GO:1904647
name: response to rotenone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rotenone stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18538940]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901654 ! response to ketone
created_by: sl
creation_date: 2015-08-31T20:55:32Z

[Term]
id: GO:1904648
name: cellular response to rotenone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rotenone stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18538940]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901655 ! cellular response to ketone
is_a: GO:1904647 ! response to rotenone
created_by: sl
creation_date: 2015-08-31T20:55:39Z

[Term]
id: GO:1904649
name: regulation of fat cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fat cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:17024416]
synonym: "regulation of adipocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "regulation of adipose cell apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "regulation of fat cell apoptosis" NARROW [GOC:TermGenie]
is_a: GO:0042981 ! regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1904606 ! fat cell apoptotic process
relationship: regulates GO:1904606 ! fat cell apoptotic process
created_by: sl
creation_date: 2015-08-31T20:59:28Z

[Term]
id: GO:1904650
name: negative regulation of fat cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of fat cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:17024416]
synonym: "down regulation of adipocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "down regulation of adipose cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down regulation of fat cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of fat cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of adipocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of adipose cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of fat cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of fat cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of adipocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of adipocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of adipose cell apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of adipose cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of fat cell apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of fat cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "inhibition of adipocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of adipocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "inhibition of adipose cell apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of adipose cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "inhibition of fat cell apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of fat cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of adipocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of adipose cell apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of fat cell apoptosis" NARROW [GOC:TermGenie]
is_a: GO:0043066 ! negative regulation of apoptotic process
is_a: GO:1904649 ! regulation of fat cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1904606 ! fat cell apoptotic process
relationship: negatively_regulates GO:1904606 ! fat cell apoptotic process
created_by: sl
creation_date: 2015-08-31T20:59:34Z

[Term]
id: GO:1904651
name: positive regulation of fat cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of fat cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:17024416]
synonym: "activation of adipocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of adipocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "activation of adipose cell apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of adipose cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "activation of fat cell apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of fat cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of adipocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of adipose cell apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of fat cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of adipocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of adipose cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of fat cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of fat cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of adipocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of adipose cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of fat cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of fat cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of adipocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of adipocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of adipose cell apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of adipose cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of fat cell apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of fat cell apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0043065 ! positive regulation of apoptotic process
is_a: GO:1904649 ! regulation of fat cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1904606 ! fat cell apoptotic process
relationship: positively_regulates GO:1904606 ! fat cell apoptotic process
created_by: sl
creation_date: 2015-08-31T20:59:40Z

[Term]
id: GO:1904652
name: protein localization to cell division site involved in cell separation after cytokinesis
namespace: biological_process
def: "Any protein localization to cell division site that is involved in cell separation after cytokinesis." [GO_REF:0000060, GOC:TermGenie, PMID:25411334]
is_a: GO:0072741 ! protein localization to cell division site
intersection_of: GO:0072741 ! protein localization to cell division site
intersection_of: part_of GO:0000920 ! cell separation after cytokinesis
relationship: part_of GO:0000920 ! cell separation after cytokinesis
created_by: vw
creation_date: 2015-09-01T21:04:45Z

[Term]
id: GO:1904653
name: regulation of lung alveolus development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lung alveolus development." [GO_REF:0000058, GOC:TermGenie, PMID:23962064]
synonym: "regulation of alveolarization" EXACT [GOC:TermGenie]
synonym: "regulation of alveologenesis" EXACT [GOC:TermGenie]
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048286 ! lung alveolus development
relationship: regulates GO:0048286 ! lung alveolus development
created_by: sl
creation_date: 2015-09-03T22:44:44Z

[Term]
id: GO:1904654
name: negative regulation of lung alveolus development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lung alveolus development." [GO_REF:0000058, GOC:TermGenie, PMID:23962064]
synonym: "down regulation of alveolarization" EXACT [GOC:TermGenie]
synonym: "down regulation of alveologenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of lung alveolus development" EXACT [GOC:TermGenie]
synonym: "down-regulation of alveolarization" EXACT [GOC:TermGenie]
synonym: "down-regulation of alveologenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of lung alveolus development" EXACT [GOC:TermGenie]
synonym: "downregulation of alveolarization" EXACT [GOC:TermGenie]
synonym: "downregulation of alveologenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of lung alveolus development" EXACT [GOC:TermGenie]
synonym: "inhibition of alveolarization" NARROW [GOC:TermGenie]
synonym: "inhibition of alveologenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of lung alveolus development" NARROW [GOC:TermGenie]
synonym: "negative regulation of alveolarization" EXACT [GOC:TermGenie]
synonym: "negative regulation of alveologenesis" EXACT [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1904653 ! regulation of lung alveolus development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048286 ! lung alveolus development
relationship: negatively_regulates GO:0048286 ! lung alveolus development
created_by: sl
creation_date: 2015-09-03T22:44:50Z

[Term]
id: GO:1904655
name: positive regulation of lung alveolus development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lung alveolus development." [GO_REF:0000058, GOC:TermGenie, PMID:23962064]
synonym: "activation of alveolarization" NARROW [GOC:TermGenie]
synonym: "activation of alveologenesis" NARROW [GOC:TermGenie]
synonym: "activation of lung alveolus development" NARROW [GOC:TermGenie]
synonym: "positive regulation of alveolarization" EXACT [GOC:TermGenie]
synonym: "positive regulation of alveologenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of alveolarization" EXACT [GOC:TermGenie]
synonym: "up regulation of alveologenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of lung alveolus development" EXACT [GOC:TermGenie]
synonym: "up-regulation of alveolarization" EXACT [GOC:TermGenie]
synonym: "up-regulation of alveologenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of lung alveolus development" EXACT [GOC:TermGenie]
synonym: "upregulation of alveolarization" EXACT [GOC:TermGenie]
synonym: "upregulation of alveologenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of lung alveolus development" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1904653 ! regulation of lung alveolus development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048286 ! lung alveolus development
relationship: positively_regulates GO:0048286 ! lung alveolus development
created_by: sl
creation_date: 2015-09-03T22:44:56Z

[Term]
id: GO:1904656
name: regulation of sensory perception of sweet taste
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sensory perception of sweet taste." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:1716172]
synonym: "regulation of sweet taste perception" EXACT [GOC:TermGenie]
is_a: GO:0051931 ! regulation of sensory perception
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050916 ! sensory perception of sweet taste
relationship: regulates GO:0050916 ! sensory perception of sweet taste
created_by: mr
creation_date: 2015-09-04T16:43:12Z

[Term]
id: GO:1904657
name: negative regulation of sensory perception of sweet taste
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sensory perception of sweet taste." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:1716172]
synonym: "down regulation of sensory perception of sweet taste" EXACT [GOC:TermGenie]
synonym: "down regulation of sweet taste perception" EXACT [GOC:TermGenie]
synonym: "down-regulation of sensory perception of sweet taste" EXACT [GOC:TermGenie]
synonym: "down-regulation of sweet taste perception" EXACT [GOC:TermGenie]
synonym: "downregulation of sensory perception of sweet taste" EXACT [GOC:TermGenie]
synonym: "downregulation of sweet taste perception" EXACT [GOC:TermGenie]
synonym: "inhibition of sensory perception of sweet taste" NARROW [GOC:TermGenie]
synonym: "inhibition of sweet taste perception" NARROW [GOC:TermGenie]
synonym: "negative regulation of sweet taste perception" EXACT [GOC:TermGenie]
is_a: GO:0031645 ! negative regulation of neurological system process
is_a: GO:1904656 ! regulation of sensory perception of sweet taste
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0050916 ! sensory perception of sweet taste
relationship: negatively_regulates GO:0050916 ! sensory perception of sweet taste
created_by: mr
creation_date: 2015-09-04T16:43:18Z

[Term]
id: GO:1904658
name: positive regulation of sensory perception of sweet taste
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sensory perception of sweet taste." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:1716172]
synonym: "activation of sensory perception of sweet taste" NARROW [GOC:TermGenie]
synonym: "activation of sweet taste perception" NARROW [GOC:TermGenie]
synonym: "positive regulation of sweet taste perception" EXACT [GOC:TermGenie]
synonym: "up regulation of sensory perception of sweet taste" EXACT [GOC:TermGenie]
synonym: "up regulation of sweet taste perception" EXACT [GOC:TermGenie]
synonym: "up-regulation of sensory perception of sweet taste" EXACT [GOC:TermGenie]
synonym: "up-regulation of sweet taste perception" EXACT [GOC:TermGenie]
synonym: "upregulation of sensory perception of sweet taste" EXACT [GOC:TermGenie]
synonym: "upregulation of sweet taste perception" EXACT [GOC:TermGenie]
is_a: GO:0031646 ! positive regulation of neurological system process
is_a: GO:1904656 ! regulation of sensory perception of sweet taste
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0050916 ! sensory perception of sweet taste
relationship: positively_regulates GO:0050916 ! sensory perception of sweet taste
created_by: mr
creation_date: 2015-09-04T16:43:24Z

[Term]
id: GO:1904659
name: glucose transmembrane transport
namespace: biological_process
def: "The directed movement of glucose across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:9090050]
is_a: GO:0015758 ! glucose transport
is_a: GO:0035428 ! hexose transmembrane transport
created_by: vw
creation_date: 2015-09-04T17:20:16Z

[Term]
id: GO:1904660
name: regulation of sensory perception of bitter taste
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sensory perception of bitter taste." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:1716172]
synonym: "regulation of bitter taste perception" EXACT [GOC:TermGenie]
is_a: GO:0051931 ! regulation of sensory perception
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050913 ! sensory perception of bitter taste
relationship: regulates GO:0050913 ! sensory perception of bitter taste
created_by: mr
creation_date: 2015-09-04T17:54:10Z

[Term]
id: GO:1904661
name: negative regulation of sensory perception of bitter taste
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sensory perception of bitter taste." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:1716172]
synonym: "down regulation of bitter taste perception" EXACT [GOC:TermGenie]
synonym: "down regulation of sensory perception of bitter taste" EXACT [GOC:TermGenie]
synonym: "down-regulation of bitter taste perception" EXACT [GOC:TermGenie]
synonym: "down-regulation of sensory perception of bitter taste" EXACT [GOC:TermGenie]
synonym: "downregulation of bitter taste perception" EXACT [GOC:TermGenie]
synonym: "downregulation of sensory perception of bitter taste" EXACT [GOC:TermGenie]
synonym: "inhibition of bitter taste perception" NARROW [GOC:TermGenie]
synonym: "inhibition of sensory perception of bitter taste" NARROW [GOC:TermGenie]
synonym: "negative regulation of bitter taste perception" EXACT [GOC:TermGenie]
is_a: GO:0031645 ! negative regulation of neurological system process
is_a: GO:1904660 ! regulation of sensory perception of bitter taste
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0050913 ! sensory perception of bitter taste
relationship: negatively_regulates GO:0050913 ! sensory perception of bitter taste
created_by: mr
creation_date: 2015-09-04T17:54:17Z

[Term]
id: GO:1904662
name: positive regulation of sensory perception of bitter taste
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sensory perception of bitter taste." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:1716172]
synonym: "activation of bitter taste perception" NARROW [GOC:TermGenie]
synonym: "activation of sensory perception of bitter taste" NARROW [GOC:TermGenie]
synonym: "positive regulation of bitter taste perception" EXACT [GOC:TermGenie]
synonym: "up regulation of bitter taste perception" EXACT [GOC:TermGenie]
synonym: "up regulation of sensory perception of bitter taste" EXACT [GOC:TermGenie]
synonym: "up-regulation of bitter taste perception" EXACT [GOC:TermGenie]
synonym: "up-regulation of sensory perception of bitter taste" EXACT [GOC:TermGenie]
synonym: "upregulation of bitter taste perception" EXACT [GOC:TermGenie]
synonym: "upregulation of sensory perception of bitter taste" EXACT [GOC:TermGenie]
is_a: GO:0031646 ! positive regulation of neurological system process
is_a: GO:1904660 ! regulation of sensory perception of bitter taste
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0050913 ! sensory perception of bitter taste
relationship: positively_regulates GO:0050913 ! sensory perception of bitter taste
created_by: mr
creation_date: 2015-09-04T17:54:22Z

[Term]
id: GO:1904663
name: regulation of N-terminal peptidyl-methionine acetylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of N-terminal peptidyl-methionine acetylation." [GO_REF:0000058, GOC:TermGenie, PMID:20807799]
is_a: GO:1901983 ! regulation of protein acetylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0017196 ! N-terminal peptidyl-methionine acetylation
relationship: regulates GO:0017196 ! N-terminal peptidyl-methionine acetylation
created_by: vw
creation_date: 2015-09-07T19:18:49Z

[Term]
id: GO:1904664
name: negative regulation of N-terminal peptidyl-methionine acetylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of N-terminal peptidyl-methionine acetylation." [GO_REF:0000058, GOC:TermGenie, PMID:20807799]
is_a: GO:1901984 ! negative regulation of protein acetylation
is_a: GO:1904663 ! regulation of N-terminal peptidyl-methionine acetylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0017196 ! N-terminal peptidyl-methionine acetylation
relationship: negatively_regulates GO:0017196 ! N-terminal peptidyl-methionine acetylation
created_by: vw
creation_date: 2015-09-07T19:18:56Z

[Term]
id: GO:1904665
name: positive regulation of N-terminal peptidyl-methionine acetylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of N-terminal peptidyl-methionine acetylation." [GO_REF:0000058, GOC:TermGenie, PMID:20807799]
is_a: GO:1901985 ! positive regulation of protein acetylation
is_a: GO:1904663 ! regulation of N-terminal peptidyl-methionine acetylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0017196 ! N-terminal peptidyl-methionine acetylation
relationship: positively_regulates GO:0017196 ! N-terminal peptidyl-methionine acetylation
created_by: vw
creation_date: 2015-09-07T19:19:02Z

[Term]
id: GO:1904666
name: regulation of ubiquitin protein ligase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ubiquitin protein ligase activity." [GO_REF:0000059, GOC:dph, GOC:TermGenie, PMID:26216882]
synonym: "regulation of E3" RELATED [GOC:TermGenie]
synonym: "regulation of protein ubiquitination activity" EXACT [GOC:TermGenie]
synonym: "regulation of ubiquitin ligase activity" EXACT [GOC:TermGenie]
is_a: GO:0051438 ! regulation of ubiquitin-protein transferase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061630 ! ubiquitin protein ligase activity
relationship: regulates GO:0061630 ! ubiquitin protein ligase activity
created_by: dph
creation_date: 2015-09-08T15:26:59Z

[Term]
id: GO:1904667
name: negative regulation of ubiquitin protein ligase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin protein ligase activity." [GO_REF:0000059, GOC:dph, GOC:TermGenie, PMID:26216882]
synonym: "down regulation of E3" RELATED [GOC:TermGenie]
synonym: "down regulation of protein ubiquitination activity" EXACT [GOC:TermGenie]
synonym: "down regulation of ubiquitin ligase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of ubiquitin protein ligase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of E3" RELATED [GOC:TermGenie]
synonym: "down-regulation of protein ubiquitination activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of ubiquitin ligase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of ubiquitin protein ligase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of E3" RELATED [GOC:TermGenie]
synonym: "downregulation of protein ubiquitination activity" EXACT [GOC:TermGenie]
synonym: "downregulation of ubiquitin ligase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of ubiquitin protein ligase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of E3" RELATED [GOC:TermGenie]
synonym: "inhibition of protein ubiquitination activity" NARROW [GOC:TermGenie]
synonym: "inhibition of ubiquitin ligase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of ubiquitin protein ligase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of E3" RELATED [GOC:TermGenie]
synonym: "negative regulation of protein ubiquitination activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of ubiquitin ligase activity" EXACT [GOC:TermGenie]
is_a: GO:0051444 ! negative regulation of ubiquitin-protein transferase activity
is_a: GO:1904666 ! regulation of ubiquitin protein ligase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061630 ! ubiquitin protein ligase activity
relationship: negatively_regulates GO:0061630 ! ubiquitin protein ligase activity
created_by: dph
creation_date: 2015-09-08T15:27:05Z

[Term]
id: GO:1904668
name: positive regulation of ubiquitin protein ligase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ubiquitin protein ligase activity." [GO_REF:0000059, GOC:dph, GOC:TermGenie, PMID:26216882]
synonym: "activation of E3" RELATED [GOC:TermGenie]
synonym: "activation of protein ubiquitination activity" NARROW [GOC:TermGenie]
synonym: "activation of ubiquitin ligase activity" NARROW [GOC:TermGenie]
synonym: "activation of ubiquitin protein ligase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of E3" RELATED [GOC:TermGenie]
synonym: "positive regulation of protein ubiquitination activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of ubiquitin ligase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of E3" RELATED [GOC:TermGenie]
synonym: "up regulation of protein ubiquitination activity" EXACT [GOC:TermGenie]
synonym: "up regulation of ubiquitin ligase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of ubiquitin protein ligase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of E3" RELATED [GOC:TermGenie]
synonym: "up-regulation of protein ubiquitination activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of ubiquitin ligase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of ubiquitin protein ligase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of E3" RELATED [GOC:TermGenie]
synonym: "upregulation of protein ubiquitination activity" EXACT [GOC:TermGenie]
synonym: "upregulation of ubiquitin ligase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of ubiquitin protein ligase activity" EXACT [GOC:TermGenie]
is_a: GO:0051443 ! positive regulation of ubiquitin-protein transferase activity
is_a: GO:1904666 ! regulation of ubiquitin protein ligase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061630 ! ubiquitin protein ligase activity
relationship: positively_regulates GO:0061630 ! ubiquitin protein ligase activity
created_by: dph
creation_date: 2015-09-08T15:27:11Z

[Term]
id: GO:1904669
name: ATP export
namespace: biological_process
def: "The directed movement of ATP out of a cell or organelle." [GO_REF:0000074, GOC:TermGenie, PMID:24286344]
synonym: "ATP efflux" RELATED []
is_a: GO:0015867 ! ATP transport
created_by: tb
creation_date: 2015-09-09T16:33:06Z

[Term]
id: GO:1904670
name: actin filament polymerization involved in mitotic actomyosin contractile ring assembly
namespace: biological_process
def: "Any actin filament polymerization that is involved in mitotic actomyosin contractile ring assembly." [GO_REF:0000060, GOC:TermGenie, PMID:24127216]
is_a: GO:0030041 ! actin filament polymerization
is_a: GO:1903479 ! mitotic actomyosin contractile ring assembly actin filament organization
intersection_of: GO:0030041 ! actin filament polymerization
intersection_of: part_of GO:1903475 ! mitotic actomyosin contractile ring assembly
relationship: part_of GO:1903475 ! mitotic actomyosin contractile ring assembly
created_by: vw
creation_date: 2015-09-09T20:05:56Z

[Term]
id: GO:1904671
name: negative regulation of cell differentiation involved in stem cell population maintenance
namespace: biological_process
def: "Any negative regulation of cell differentiation that is involved in stem cell population maintenance." [GO_REF:0000060, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607]
synonym: "down regulation of cell differentiation involved in maintenance of pluripotency" RELATED [GOC:TermGenie]
synonym: "down regulation of cell differentiation involved in stem cell population maintenance" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell differentiation involved in maintenance of pluripotency" RELATED [GOC:TermGenie]
synonym: "down-regulation of cell differentiation involved in stem cell population maintenance" EXACT [GOC:TermGenie]
synonym: "downregulation of cell differentiation involved in maintenance of pluripotency" RELATED [GOC:TermGenie]
synonym: "downregulation of cell differentiation involved in stem cell population maintenance" EXACT [GOC:TermGenie]
synonym: "inhibition of cell differentiation involved in maintenance of pluripotency" RELATED [GOC:TermGenie]
synonym: "inhibition of cell differentiation involved in stem cell population maintenance" NARROW [GOC:TermGenie]
synonym: "negative regulation of cell differentiation involved in maintenance of pluripotency" RELATED [GOC:TermGenie]
is_a: GO:0045596 ! negative regulation of cell differentiation
intersection_of: GO:0045596 ! negative regulation of cell differentiation
intersection_of: part_of GO:0019827 ! stem cell population maintenance
relationship: part_of GO:0019827 ! stem cell population maintenance
created_by: tb
creation_date: 2015-09-12T00:46:08Z

[Term]
id: GO:1904672
name: regulation of somatic stem cell population maintenance
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of somatic stem cell population maintenance." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607]
is_a: GO:2000036 ! regulation of stem cell population maintenance
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035019 ! somatic stem cell population maintenance
relationship: regulates GO:0035019 ! somatic stem cell population maintenance
created_by: rph
creation_date: 2015-09-14T08:40:19Z

[Term]
id: GO:1904673
name: negative regulation of somatic stem cell population maintenance
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of somatic stem cell population maintenance." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607]
synonym: "down regulation of somatic stem cell population maintenance" EXACT [GOC:TermGenie]
synonym: "down-regulation of somatic stem cell population maintenance" EXACT [GOC:TermGenie]
synonym: "downregulation of somatic stem cell population maintenance" EXACT [GOC:TermGenie]
synonym: "inhibition of somatic stem cell population maintenance" NARROW [GOC:TermGenie]
is_a: GO:1902455 ! negative regulation of stem cell population maintenance
is_a: GO:1904672 ! regulation of somatic stem cell population maintenance
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035019 ! somatic stem cell population maintenance
relationship: negatively_regulates GO:0035019 ! somatic stem cell population maintenance
created_by: rph
creation_date: 2015-09-14T08:40:25Z

[Term]
id: GO:1904674
name: positive regulation of somatic stem cell population maintenance
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of somatic stem cell population maintenance." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607]
synonym: "activation of somatic stem cell population maintenance" NARROW [GOC:TermGenie]
synonym: "up regulation of somatic stem cell population maintenance" EXACT [GOC:TermGenie]
synonym: "up-regulation of somatic stem cell population maintenance" EXACT [GOC:TermGenie]
synonym: "upregulation of somatic stem cell population maintenance" EXACT [GOC:TermGenie]
is_a: GO:1902459 ! positive regulation of stem cell population maintenance
is_a: GO:1904672 ! regulation of somatic stem cell population maintenance
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035019 ! somatic stem cell population maintenance
relationship: positively_regulates GO:0035019 ! somatic stem cell population maintenance
created_by: rph
creation_date: 2015-09-14T08:40:32Z

[Term]
id: GO:1904675
name: regulation of somatic stem cell division
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of somatic stem cell division." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607]
synonym: "regulation of somatic stem cell renewal" EXACT [GOC:TermGenie]
is_a: GO:2000035 ! regulation of stem cell division
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048103 ! somatic stem cell division
relationship: regulates GO:0048103 ! somatic stem cell division
created_by: rph
creation_date: 2015-09-14T08:47:22Z

[Term]
id: GO:1904676
name: negative regulation of somatic stem cell division
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of somatic stem cell division." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607]
synonym: "down regulation of somatic stem cell division" EXACT [GOC:TermGenie]
synonym: "down regulation of somatic stem cell renewal" EXACT [GOC:TermGenie]
synonym: "down-regulation of somatic stem cell division" EXACT [GOC:TermGenie]
synonym: "down-regulation of somatic stem cell renewal" EXACT [GOC:TermGenie]
synonym: "downregulation of somatic stem cell division" EXACT [GOC:TermGenie]
synonym: "downregulation of somatic stem cell renewal" EXACT [GOC:TermGenie]
synonym: "inhibition of somatic stem cell division" NARROW [GOC:TermGenie]
synonym: "inhibition of somatic stem cell renewal" NARROW [GOC:TermGenie]
synonym: "negative regulation of somatic stem cell renewal" EXACT [GOC:TermGenie]
is_a: GO:0051782 ! negative regulation of cell division
is_a: GO:1904675 ! regulation of somatic stem cell division
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048103 ! somatic stem cell division
relationship: negatively_regulates GO:0048103 ! somatic stem cell division
created_by: rph
creation_date: 2015-09-14T08:47:28Z

[Term]
id: GO:1904677
name: positive regulation of somatic stem cell division
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of somatic stem cell division." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607]
synonym: "activation of somatic stem cell division" NARROW [GOC:TermGenie]
synonym: "activation of somatic stem cell renewal" NARROW [GOC:TermGenie]
synonym: "positive regulation of somatic stem cell renewal" EXACT [GOC:TermGenie]
synonym: "up regulation of somatic stem cell division" EXACT [GOC:TermGenie]
synonym: "up regulation of somatic stem cell renewal" EXACT [GOC:TermGenie]
synonym: "up-regulation of somatic stem cell division" EXACT [GOC:TermGenie]
synonym: "up-regulation of somatic stem cell renewal" EXACT [GOC:TermGenie]
synonym: "upregulation of somatic stem cell division" EXACT [GOC:TermGenie]
synonym: "upregulation of somatic stem cell renewal" EXACT [GOC:TermGenie]
is_a: GO:0051781 ! positive regulation of cell division
is_a: GO:1904675 ! regulation of somatic stem cell division
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048103 ! somatic stem cell division
relationship: positively_regulates GO:0048103 ! somatic stem cell division
created_by: rph
creation_date: 2015-09-14T08:47:34Z

[Term]
id: GO:1904678
name: alpha-aminoacyl-tRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with alpha-aminoacyl-tRNA." [GO_REF:0000067, GOC:TermGenie, ISBN:155581073x]
synonym: "aminoacyl-tRNA binding" RELATED []
is_a: GO:0003723 ! RNA binding
created_by: hjd
creation_date: 2015-09-18T16:44:17Z

[Term]
id: GO:1904679
name: myo-inositol import across plasma membrane
namespace: biological_process
def: "The directed movement of myo-inositol from outside of a cell into the cytoplasmic compartment." [GO_REF:0000075, GOC:TermGenie, PMID:9560432]
is_a: GO:0097357 ! myo-inositol import into cell
is_a: GO:0098739 ! import across plasma membrane
created_by: al
creation_date: 2015-09-21T14:05:38Z

[Term]
id: GO:1904680
name: peptide transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of peptide from one side of the membrane to the other." [GO_REF:0000070, GOC:TermGenie, GOC:vw]
is_a: GO:0015197 ! peptide transporter activity
is_a: GO:0042887 ! amide transmembrane transporter activity
created_by: tb
creation_date: 2015-09-22T18:50:41Z

[Term]
id: GO:1904681
name: response to 3-methylcholanthrene
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 3-methylcholanthrene stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:9224771]
is_a: GO:1903165 ! response to polycyclic arene
created_by: mr
creation_date: 2015-09-22T19:50:03Z

[Term]
id: GO:1904682
name: cellular response to 3-methylcholanthrene
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 3-methylcholanthrene stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:9224771]
is_a: GO:1903166 ! cellular response to polycyclic arene
is_a: GO:1904681 ! response to 3-methylcholanthrene
created_by: mr
creation_date: 2015-09-22T19:50:10Z

[Term]
id: GO:1904683
name: regulation of metalloendopeptidase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of metalloendopeptidase activity." [GO_REF:0000059, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:18591254]
synonym: "regulation of metalloendoprotease activity" NARROW [GOC:TermGenie]
synonym: "regulation of metalloendoproteinase activity" NARROW [GOC:TermGenie]
is_a: GO:0052548 ! regulation of endopeptidase activity
is_a: GO:1905048 ! regulation of metallopeptidase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004222 ! metalloendopeptidase activity
relationship: regulates GO:0004222 ! metalloendopeptidase activity
created_by: rph
creation_date: 2015-09-24T11:18:14Z

[Term]
id: GO:1904684
name: negative regulation of metalloendopeptidase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of metalloendopeptidase activity." [GO_REF:0000059, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:18591254]
synonym: "down regulation of metalloendopeptidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of metalloendoprotease activity" NARROW [GOC:TermGenie]
synonym: "down regulation of metalloendoproteinase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of metalloendopeptidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of metalloendoprotease activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of metalloendoproteinase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of metalloendopeptidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of metalloendoprotease activity" NARROW [GOC:TermGenie]
synonym: "downregulation of metalloendoproteinase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of metalloendopeptidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of metalloendoprotease activity" NARROW [GOC:TermGenie]
synonym: "inhibition of metalloendoproteinase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of metalloendoprotease activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of metalloendoproteinase activity" NARROW [GOC:TermGenie]
is_a: GO:0010951 ! negative regulation of endopeptidase activity
is_a: GO:1904683 ! regulation of metalloendopeptidase activity
is_a: GO:1905049 ! negative regulation of metallopeptidase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004222 ! metalloendopeptidase activity
relationship: negatively_regulates GO:0004222 ! metalloendopeptidase activity
created_by: rph
creation_date: 2015-09-24T11:18:21Z

[Term]
id: GO:1904685
name: positive regulation of metalloendopeptidase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of metalloendopeptidase activity." [GO_REF:0000059, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:18591254]
synonym: "activation of metalloendopeptidase activity" NARROW [GOC:TermGenie]
synonym: "activation of metalloendoprotease activity" NARROW [GOC:TermGenie]
synonym: "activation of metalloendoproteinase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of metalloendoprotease activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of metalloendoproteinase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of metalloendopeptidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of metalloendoprotease activity" NARROW [GOC:TermGenie]
synonym: "up regulation of metalloendoproteinase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of metalloendopeptidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of metalloendoprotease activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of metalloendoproteinase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of metalloendopeptidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of metalloendoprotease activity" NARROW [GOC:TermGenie]
synonym: "upregulation of metalloendoproteinase activity" NARROW [GOC:TermGenie]
is_a: GO:0010950 ! positive regulation of endopeptidase activity
is_a: GO:1904683 ! regulation of metalloendopeptidase activity
is_a: GO:1905050 ! positive regulation of metallopeptidase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004222 ! metalloendopeptidase activity
relationship: positively_regulates GO:0004222 ! metalloendopeptidase activity
created_by: rph
creation_date: 2015-09-24T11:18:28Z

[Term]
id: GO:1904686
name: regulation of mitotic spindle disassembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitotic spindle disassembly." [GO_REF:0000058, GOC:TermGenie, PMID:25963819]
synonym: "regulation of mitotic spindle breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of mitotic spindle catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of mitotic spindle degradation" EXACT [GOC:TermGenie]
synonym: "regulation of spindle breakdown during mitosis" EXACT [GOC:TermGenie]
synonym: "regulation of spindle degradation during mitosis" EXACT [GOC:TermGenie]
synonym: "regulation of spindle disassembly during mitosis" EXACT [GOC:TermGenie]
is_a: GO:0060236 ! regulation of mitotic spindle organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051228 ! mitotic spindle disassembly
relationship: regulates GO:0051228 ! mitotic spindle disassembly
created_by: al
creation_date: 2015-09-24T14:20:07Z

[Term]
id: GO:1904687
name: positive regulation of mitotic spindle disassembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitotic spindle disassembly." [GO_REF:0000058, GOC:TermGenie, PMID:25963819]
synonym: "activation of mitotic spindle breakdown" NARROW [GOC:TermGenie]
synonym: "activation of mitotic spindle catabolism" NARROW [GOC:TermGenie]
synonym: "activation of mitotic spindle degradation" NARROW [GOC:TermGenie]
synonym: "activation of mitotic spindle disassembly" NARROW [GOC:TermGenie]
synonym: "activation of spindle breakdown during mitosis" NARROW [GOC:TermGenie]
synonym: "activation of spindle degradation during mitosis" NARROW [GOC:TermGenie]
synonym: "activation of spindle disassembly during mitosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of mitotic spindle breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of mitotic spindle catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of mitotic spindle degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of spindle breakdown during mitosis" EXACT [GOC:TermGenie]
synonym: "positive regulation of spindle degradation during mitosis" EXACT [GOC:TermGenie]
synonym: "positive regulation of spindle disassembly during mitosis" EXACT [GOC:TermGenie]
synonym: "up regulation of mitotic spindle breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of mitotic spindle catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of mitotic spindle degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of mitotic spindle disassembly" EXACT [GOC:TermGenie]
synonym: "up regulation of spindle breakdown during mitosis" EXACT [GOC:TermGenie]
synonym: "up regulation of spindle degradation during mitosis" EXACT [GOC:TermGenie]
synonym: "up regulation of spindle disassembly during mitosis" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitotic spindle breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitotic spindle catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitotic spindle degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitotic spindle disassembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of spindle breakdown during mitosis" EXACT [GOC:TermGenie]
synonym: "up-regulation of spindle degradation during mitosis" EXACT [GOC:TermGenie]
synonym: "up-regulation of spindle disassembly during mitosis" EXACT [GOC:TermGenie]
synonym: "upregulation of mitotic spindle breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of mitotic spindle catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of mitotic spindle degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of mitotic spindle disassembly" EXACT [GOC:TermGenie]
synonym: "upregulation of spindle breakdown during mitosis" EXACT [GOC:TermGenie]
synonym: "upregulation of spindle degradation during mitosis" EXACT [GOC:TermGenie]
synonym: "upregulation of spindle disassembly during mitosis" EXACT [GOC:TermGenie]
is_a: GO:0043243 ! positive regulation of protein complex disassembly
is_a: GO:0045931 ! positive regulation of mitotic cell cycle
is_a: GO:0051495 ! positive regulation of cytoskeleton organization
is_a: GO:0090068 ! positive regulation of cell cycle process
is_a: GO:1904686 ! regulation of mitotic spindle disassembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051228 ! mitotic spindle disassembly
relationship: positively_regulates GO:0051228 ! mitotic spindle disassembly
created_by: al
creation_date: 2015-09-24T14:20:13Z

[Term]
id: GO:1904688
name: regulation of cytoplasmic translational initiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cytoplasmic translational initiation." [GO_REF:0000058, GOC:TermGenie, PMID:12242291]
is_a: GO:0006446 ! regulation of translational initiation
is_a: GO:2000765 ! regulation of cytoplasmic translation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002183 ! cytoplasmic translational initiation
relationship: regulates GO:0002183 ! cytoplasmic translational initiation
created_by: dos
creation_date: 2015-09-25T14:39:38Z

[Term]
id: GO:1904689
name: negative regulation of cytoplasmic translational initiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translational initiation." [GO_REF:0000058, GOC:TermGenie, PMID:12242291]
synonym: "down regulation of cytoplasmic translational initiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of cytoplasmic translational initiation" EXACT [GOC:TermGenie]
synonym: "downregulation of cytoplasmic translational initiation" EXACT [GOC:TermGenie]
synonym: "inhibition of cytoplasmic translational initiation" NARROW [GOC:TermGenie]
is_a: GO:0045947 ! negative regulation of translational initiation
is_a: GO:1904688 ! regulation of cytoplasmic translational initiation
is_a: GO:2000766 ! negative regulation of cytoplasmic translation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002183 ! cytoplasmic translational initiation
relationship: negatively_regulates GO:0002183 ! cytoplasmic translational initiation
created_by: dos
creation_date: 2015-09-25T14:39:44Z

[Term]
id: GO:1904690
name: positive regulation of cytoplasmic translational initiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cytoplasmic translational initiation." [GO_REF:0000058, GOC:TermGenie, PMID:12242291]
synonym: "activation of cytoplasmic translational initiation" NARROW [GOC:TermGenie]
synonym: "up regulation of cytoplasmic translational initiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of cytoplasmic translational initiation" EXACT [GOC:TermGenie]
synonym: "upregulation of cytoplasmic translational initiation" EXACT [GOC:TermGenie]
is_a: GO:0045948 ! positive regulation of translational initiation
is_a: GO:1904688 ! regulation of cytoplasmic translational initiation
is_a: GO:2000767 ! positive regulation of cytoplasmic translation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002183 ! cytoplasmic translational initiation
relationship: positively_regulates GO:0002183 ! cytoplasmic translational initiation
created_by: dos
creation_date: 2015-09-25T14:39:50Z

[Term]
id: GO:1904691
name: negative regulation of type B pancreatic cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24055447]
synonym: "down regulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie]
synonym: "down regulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie]
synonym: "down regulation of type B pancreatic cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of type B pancreatic cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of type B pancreatic cell proliferation" EXACT [GOC:TermGenie]
synonym: "inhibition of pancreatic B cell proliferation" NARROW [GOC:TermGenie]
synonym: "inhibition of pancreatic beta cell proliferation" NARROW [GOC:TermGenie]
synonym: "inhibition of type B pancreatic cell proliferation" NARROW [GOC:TermGenie]
synonym: "negative regulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie]
synonym: "negative regulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0050680 ! negative regulation of epithelial cell proliferation
is_a: GO:0061469 ! regulation of type B pancreatic cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044342 ! type B pancreatic cell proliferation
relationship: negatively_regulates GO:0044342 ! type B pancreatic cell proliferation
created_by: sl
creation_date: 2015-09-25T15:23:38Z

[Term]
id: GO:1904692
name: positive regulation of type B pancreatic cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of type B pancreatic cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24055447]
synonym: "activation of pancreatic B cell proliferation" NARROW [GOC:TermGenie]
synonym: "activation of pancreatic beta cell proliferation" NARROW [GOC:TermGenie]
synonym: "activation of type B pancreatic cell proliferation" NARROW [GOC:TermGenie]
synonym: "positive regulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie]
synonym: "positive regulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of type B pancreatic cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of type B pancreatic cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of type B pancreatic cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0050679 ! positive regulation of epithelial cell proliferation
is_a: GO:0061469 ! regulation of type B pancreatic cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044342 ! type B pancreatic cell proliferation
relationship: positively_regulates GO:0044342 ! type B pancreatic cell proliferation
created_by: sl
creation_date: 2015-09-25T15:23:44Z

[Term]
id: GO:1904693
name: midbrain morphogenesis
namespace: biological_process
def: "The developmental process by which a midbrain is generated and organized." [GO_REF:0000083, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21347250]
synonym: "MB morphogenesis" BROAD [GOC:TermGenie]
synonym: "mesencephalon morphogenesis" RELATED [GOC:TermGenie]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0030901 ! midbrain development
relationship: part_of GO:0048854 ! brain morphogenesis
created_by: bf
creation_date: 2015-09-29T09:15:28Z

[Term]
id: GO:1904694
name: negative regulation of vascular smooth muscle contraction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle contraction." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22158624]
synonym: "down regulation of vascular smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "down-regulation of vascular smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "downregulation of vascular smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "inhibition of vascular smooth muscle contraction" NARROW [GOC:TermGenie]
is_a: GO:0003056 ! regulation of vascular smooth muscle contraction
is_a: GO:0045906 ! negative regulation of vasoconstriction
is_a: GO:0045986 ! negative regulation of smooth muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0014829 ! vascular smooth muscle contraction
relationship: negatively_regulates GO:0014829 ! vascular smooth muscle contraction
created_by: rph
creation_date: 2015-09-29T13:39:08Z

[Term]
id: GO:1904695
name: positive regulation of vascular smooth muscle contraction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vascular smooth muscle contraction." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22158624]
synonym: "activation of vascular smooth muscle contraction" NARROW [GOC:TermGenie]
synonym: "up regulation of vascular smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "up-regulation of vascular smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "upregulation of vascular smooth muscle contraction" EXACT [GOC:TermGenie]
is_a: GO:0003056 ! regulation of vascular smooth muscle contraction
is_a: GO:0045907 ! positive regulation of vasoconstriction
is_a: GO:0045987 ! positive regulation of smooth muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0014829 ! vascular smooth muscle contraction
relationship: positively_regulates GO:0014829 ! vascular smooth muscle contraction
created_by: rph
creation_date: 2015-09-29T13:39:14Z

[Term]
id: GO:1904696
name: protein localization to cell-cell adherens junction
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a cell-cell adherens junction." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:26412237]
synonym: "protein localisation in cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "protein localisation to cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "protein localization in cell-cell adherens junction" EXACT [GOC:TermGenie]
is_a: GO:0071896 ! protein localization to adherens junction
created_by: kmv
creation_date: 2015-09-29T16:59:45Z

[Term]
id: GO:1904697
name: regulation of acinar cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of acinar cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:9788538]
synonym: "regulation of acinic cell proliferation" EXACT [GOC:TermGenie]
synonym: "regulation of acinous cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0050678 ! regulation of epithelial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990863 ! acinar cell proliferation
relationship: regulates GO:1990863 ! acinar cell proliferation
created_by: sl
creation_date: 2015-09-30T15:19:50Z

[Term]
id: GO:1904698
name: negative regulation of acinar cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of acinar cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:9788538]
synonym: "down regulation of acinar cell proliferation" EXACT [GOC:TermGenie]
synonym: "down regulation of acinic cell proliferation" EXACT [GOC:TermGenie]
synonym: "down regulation of acinous cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of acinar cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of acinic cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of acinous cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of acinar cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of acinic cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of acinous cell proliferation" EXACT [GOC:TermGenie]
synonym: "inhibition of acinar cell proliferation" NARROW [GOC:TermGenie]
synonym: "inhibition of acinic cell proliferation" NARROW [GOC:TermGenie]
synonym: "inhibition of acinous cell proliferation" NARROW [GOC:TermGenie]
synonym: "negative regulation of acinic cell proliferation" EXACT [GOC:TermGenie]
synonym: "negative regulation of acinous cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0050680 ! negative regulation of epithelial cell proliferation
is_a: GO:1904697 ! regulation of acinar cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990863 ! acinar cell proliferation
relationship: negatively_regulates GO:1990863 ! acinar cell proliferation
created_by: sl
creation_date: 2015-09-30T15:19:57Z

[Term]
id: GO:1904699
name: positive regulation of acinar cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of acinar cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:9788538]
synonym: "activation of acinar cell proliferation" NARROW [GOC:TermGenie]
synonym: "activation of acinic cell proliferation" NARROW [GOC:TermGenie]
synonym: "activation of acinous cell proliferation" NARROW [GOC:TermGenie]
synonym: "positive regulation of acinic cell proliferation" EXACT [GOC:TermGenie]
synonym: "positive regulation of acinous cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of acinar cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of acinic cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of acinous cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of acinar cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of acinic cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of acinous cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of acinar cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of acinic cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of acinous cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0050679 ! positive regulation of epithelial cell proliferation
is_a: GO:1904697 ! regulation of acinar cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990863 ! acinar cell proliferation
relationship: positively_regulates GO:1990863 ! acinar cell proliferation
created_by: sl
creation_date: 2015-09-30T15:20:03Z

[Term]
id: GO:1904700
name: granulosa cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a granulosa cell." [GO_REF:0000085, GOC:TermGenie, PMID:19208546]
synonym: "granulosa cell apoptosis" NARROW [GOC:TermGenie]
synonym: "granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie]
synonym: "granulosa cell of ovary apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:1904019 ! epithelial cell apoptotic process
created_by: sl
creation_date: 2015-09-30T21:29:54Z

[Term]
id: GO:1904701
name: Wnt-Frizzled-LRP5/6 complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a Wnt-Frizzled-LRP5/6 complex." [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11448771]
synonym: "Frizzled-LRP5/6 complex assembly" RELATED [GOC:bf]
synonym: "Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie]
synonym: "Wnt receptor complex assembly" BROAD [GOC:bf]
synonym: "WNT-FZD-LRP5 complex assembly" NARROW [GOC:TermGenie]
synonym: "WNT-FZD-LRP5 complex formation" NARROW [GOC:TermGenie]
synonym: "Wnt-FZD-LRP5/6 trimeric complex assembly" EXACT [GOC:TermGenie]
synonym: "Wnt-FZD-LRP5/6 trimeric complex formation" EXACT [GOC:TermGenie]
synonym: "WNT-FZD-LRP6 complex assembly" NARROW [GOC:TermGenie]
synonym: "WNT-FZD-LRP6 complex formation" NARROW [GOC:TermGenie]
synonym: "Wnt-induced Frizzled-LRP5/6 complex assembly" RELATED [GOC:TermGenie]
synonym: "Wnt-induced Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie]
is_a: GO:0006461 ! protein complex assembly
created_by: bf
creation_date: 2015-10-01T09:37:57Z

[Term]
id: GO:1904702
name: regulation of protein localization to cell-cell adherens junction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to cell-cell adherens junction." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:26412237]
synonym: "regulation of protein localisation in cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "regulation of protein localisation to cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "regulation of protein localization in cell-cell adherens junction" EXACT [GOC:TermGenie]
is_a: GO:0032880 ! regulation of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1904696 ! protein localization to cell-cell adherens junction
relationship: regulates GO:1904696 ! protein localization to cell-cell adherens junction
created_by: kmv
creation_date: 2015-10-01T15:11:49Z

[Term]
id: GO:1904703
name: negative regulation of protein localization to cell-cell adherens junction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell-cell adherens junction." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:26412237]
synonym: "down regulation of protein localisation in cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localisation to cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization in cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation in cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation to cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization in cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation in cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation to cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization in cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localisation in cell-cell adherens junction" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localisation to cell-cell adherens junction" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization in cell-cell adherens junction" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to cell-cell adherens junction" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation in cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localisation to cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localization in cell-cell adherens junction" EXACT [GOC:TermGenie]
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:1904702 ! regulation of protein localization to cell-cell adherens junction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1904696 ! protein localization to cell-cell adherens junction
relationship: negatively_regulates GO:1904696 ! protein localization to cell-cell adherens junction
created_by: kmv
creation_date: 2015-10-01T15:11:56Z

[Term]
id: GO:1904704
name: positive regulation of protein localization to cell-cell adherens junction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to cell-cell adherens junction." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:26412237]
synonym: "activation of protein localisation in cell-cell adherens junction" NARROW [GOC:TermGenie]
synonym: "activation of protein localisation to cell-cell adherens junction" NARROW [GOC:TermGenie]
synonym: "activation of protein localization in cell-cell adherens junction" NARROW [GOC:TermGenie]
synonym: "activation of protein localization to cell-cell adherens junction" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein localisation in cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localisation to cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localization in cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation in cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation to cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization in cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation in cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation to cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization in cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation in cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation to cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization in cell-cell adherens junction" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to cell-cell adherens junction" EXACT [GOC:TermGenie]
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:1904702 ! regulation of protein localization to cell-cell adherens junction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1904696 ! protein localization to cell-cell adherens junction
relationship: positively_regulates GO:1904696 ! protein localization to cell-cell adherens junction
created_by: kmv
creation_date: 2015-10-01T15:12:02Z

[Term]
id: GO:1904705
name: regulation of vascular smooth muscle cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vascular smooth muscle cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:23246467]
synonym: "regulation of VSMC proliferation" EXACT [GOC:TermGenie]
is_a: GO:0048660 ! regulation of smooth muscle cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990874 ! vascular smooth muscle cell proliferation
relationship: regulates GO:1990874 ! vascular smooth muscle cell proliferation
created_by: sl
creation_date: 2015-10-01T16:05:20Z

[Term]
id: GO:1904706
name: negative regulation of vascular smooth muscle cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:23246467]
synonym: "down regulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie]
synonym: "down regulation of VSMC proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of VSMC proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of VSMC proliferation" EXACT [GOC:TermGenie]
synonym: "inhibition of vascular smooth muscle cell proliferation" NARROW [GOC:TermGenie]
synonym: "inhibition of VSMC proliferation" NARROW [GOC:TermGenie]
synonym: "negative regulation of VSMC proliferation" EXACT [GOC:TermGenie]
is_a: GO:0048662 ! negative regulation of smooth muscle cell proliferation
is_a: GO:1904705 ! regulation of vascular smooth muscle cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990874 ! vascular smooth muscle cell proliferation
relationship: negatively_regulates GO:1990874 ! vascular smooth muscle cell proliferation
created_by: sl
creation_date: 2015-10-01T16:05:26Z

[Term]
id: GO:1904707
name: positive regulation of vascular smooth muscle cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:23246467]
synonym: "activation of vascular smooth muscle cell proliferation" NARROW [GOC:TermGenie]
synonym: "activation of VSMC proliferation" NARROW [GOC:TermGenie]
synonym: "positive regulation of VSMC proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of VSMC proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of VSMC proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of VSMC proliferation" EXACT [GOC:TermGenie]
is_a: GO:0048661 ! positive regulation of smooth muscle cell proliferation
is_a: GO:1904705 ! regulation of vascular smooth muscle cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990874 ! vascular smooth muscle cell proliferation
relationship: positively_regulates GO:1990874 ! vascular smooth muscle cell proliferation
created_by: sl
creation_date: 2015-10-01T16:05:32Z

[Term]
id: GO:1904708
name: regulation of granulosa cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of granulosa cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:19208546]
synonym: "regulation of granulosa cell apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of granulosa cell of ovary apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:1904035 ! regulation of epithelial cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1904700 ! granulosa cell apoptotic process
relationship: regulates GO:1904700 ! granulosa cell apoptotic process
created_by: sl
creation_date: 2015-10-01T16:09:38Z

[Term]
id: GO:1904709
name: negative regulation of granulosa cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of granulosa cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:19208546]
synonym: "down regulation of granulosa cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of granulosa cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down regulation of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of granulosa cell of ovary apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of granulosa cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of granulosa cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of granulosa cell of ovary apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of granulosa cell apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of granulosa cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of granulosa cell of ovary apoptotic process" EXACT [GOC:TermGenie]
synonym: "inhibition of granulosa cell apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of granulosa cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "inhibition of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of granulosa cell of ovary apoptotic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of granulosa cell apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of granulosa cell of ovary apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:1904036 ! negative regulation of epithelial cell apoptotic process
is_a: GO:1904708 ! regulation of granulosa cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1904700 ! granulosa cell apoptotic process
relationship: negatively_regulates GO:1904700 ! granulosa cell apoptotic process
created_by: sl
creation_date: 2015-10-01T16:09:45Z

[Term]
id: GO:1904710
name: positive regulation of granulosa cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of granulosa cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:19208546]
synonym: "activation of granulosa cell apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of granulosa cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "activation of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of granulosa cell of ovary apoptotic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of granulosa cell apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of granulosa cell of ovary apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of granulosa cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of granulosa cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of granulosa cell of ovary apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of granulosa cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of granulosa cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of granulosa cell of ovary apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of granulosa cell apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of granulosa cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of granulosa cell of ovary apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:1904037 ! positive regulation of epithelial cell apoptotic process
is_a: GO:1904708 ! regulation of granulosa cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1904700 ! granulosa cell apoptotic process
relationship: positively_regulates GO:1904700 ! granulosa cell apoptotic process
created_by: sl
creation_date: 2015-10-01T16:09:51Z

[Term]
id: GO:1904711
name: regulation of Wnt-Frizzled-LRP5/6 complex assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Wnt-Frizzled-LRP5/6 complex assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "regulation of Frizzled-LRP5/6 complex assembly" RELATED [GOC:bf]
synonym: "regulation of Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie]
synonym: "regulation of Wnt receptor complex assembly" BROAD [GOC:TermGenie]
synonym: "regulation of WNT-FZD-LRP5 complex assembly" NARROW [GOC:TermGenie]
synonym: "regulation of WNT-FZD-LRP5 complex formation" NARROW [GOC:TermGenie]
synonym: "regulation of Wnt-FZD-LRP5/6 trimeric complex assembly" EXACT [GOC:TermGenie]
synonym: "regulation of Wnt-FZD-LRP5/6 trimeric complex formation" EXACT [GOC:TermGenie]
synonym: "regulation of WNT-FZD-LRP6 complex assembly" NARROW [GOC:TermGenie]
synonym: "regulation of WNT-FZD-LRP6 complex formation" NARROW [GOC:TermGenie]
synonym: "regulation of Wnt-induced Frizzled-LRP5/6 complex assembly" RELATED [GOC:TermGenie]
synonym: "regulation of Wnt-induced Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie]
is_a: GO:0043254 ! regulation of protein complex assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1904701 ! Wnt-Frizzled-LRP5/6 complex assembly
relationship: regulates GO:1904701 ! Wnt-Frizzled-LRP5/6 complex assembly
created_by: bf
creation_date: 2015-10-05T14:02:22Z

[Term]
id: GO:1904712
name: positive regulation of Wnt-Frizzled-LRP5/6 complex assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of Wnt-Frizzled-LRP5/6 complex assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "activation of Frizzled-LRP5/6 complex assembly" NARROW [GOC:TermGenie]
synonym: "activation of Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie]
synonym: "activation of WNT-FZD-LRP5 complex assembly" NARROW [GOC:TermGenie]
synonym: "activation of WNT-FZD-LRP5 complex formation" NARROW [GOC:TermGenie]
synonym: "activation of Wnt-FZD-LRP5/6 trimeric complex assembly" NARROW [GOC:TermGenie]
synonym: "activation of Wnt-FZD-LRP5/6 trimeric complex formation" NARROW [GOC:TermGenie]
synonym: "activation of WNT-FZD-LRP6 complex assembly" NARROW [GOC:TermGenie]
synonym: "activation of WNT-FZD-LRP6 complex formation" NARROW [GOC:TermGenie]
synonym: "activation of Wnt-induced Frizzled-LRP5/6 complex assembly" RELATED [GOC:TermGenie]
synonym: "activation of Wnt-induced Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie]
synonym: "positive regulation of Frizzled-LRP5/6 complex assembly" RELATED [GOC:bf]
synonym: "positive regulation of Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie]
synonym: "positive regulation of WNT-FZD-LRP5 complex assembly" NARROW [GOC:TermGenie]
synonym: "positive regulation of WNT-FZD-LRP5 complex formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of Wnt-FZD-LRP5/6 trimeric complex assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of Wnt-FZD-LRP5/6 trimeric complex formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of WNT-FZD-LRP6 complex assembly" NARROW [GOC:TermGenie]
synonym: "positive regulation of WNT-FZD-LRP6 complex formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of Wnt-induced Frizzled-LRP5/6 complex assembly" RELATED [GOC:TermGenie]
synonym: "positive regulation of Wnt-induced Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie]
synonym: "up regulation of Frizzled-LRP5/6 complex assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie]
synonym: "up regulation of WNT-FZD-LRP5 complex assembly" NARROW [GOC:TermGenie]
synonym: "up regulation of WNT-FZD-LRP5 complex formation" NARROW [GOC:TermGenie]
synonym: "up regulation of Wnt-FZD-LRP5/6 trimeric complex assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of Wnt-FZD-LRP5/6 trimeric complex formation" EXACT [GOC:TermGenie]
synonym: "up regulation of WNT-FZD-LRP6 complex assembly" NARROW [GOC:TermGenie]
synonym: "up regulation of WNT-FZD-LRP6 complex formation" NARROW [GOC:TermGenie]
synonym: "up regulation of Wnt-induced Frizzled-LRP5/6 complex assembly" RELATED [GOC:TermGenie]
synonym: "up regulation of Wnt-induced Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie]
synonym: "up-regulation of Frizzled-LRP5/6 complex assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie]
synonym: "up-regulation of WNT-FZD-LRP5 complex assembly" NARROW [GOC:TermGenie]
synonym: "up-regulation of WNT-FZD-LRP5 complex formation" NARROW [GOC:TermGenie]
synonym: "up-regulation of Wnt-FZD-LRP5/6 trimeric complex assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of Wnt-FZD-LRP5/6 trimeric complex formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of WNT-FZD-LRP6 complex assembly" NARROW [GOC:TermGenie]
synonym: "up-regulation of WNT-FZD-LRP6 complex formation" NARROW [GOC:TermGenie]
synonym: "up-regulation of Wnt-induced Frizzled-LRP5/6 complex assembly" RELATED [GOC:TermGenie]
synonym: "up-regulation of Wnt-induced Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie]
synonym: "upregulation of Frizzled-LRP5/6 complex assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie]
synonym: "upregulation of WNT-FZD-LRP5 complex assembly" NARROW [GOC:TermGenie]
synonym: "upregulation of WNT-FZD-LRP5 complex formation" NARROW [GOC:TermGenie]
synonym: "upregulation of Wnt-FZD-LRP5/6 trimeric complex assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of Wnt-FZD-LRP5/6 trimeric complex formation" EXACT [GOC:TermGenie]
synonym: "upregulation of WNT-FZD-LRP6 complex assembly" NARROW [GOC:TermGenie]
synonym: "upregulation of WNT-FZD-LRP6 complex formation" NARROW [GOC:TermGenie]
synonym: "upregulation of Wnt-induced Frizzled-LRP5/6 complex assembly" RELATED [GOC:TermGenie]
synonym: "upregulation of Wnt-induced Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie]
is_a: GO:0031334 ! positive regulation of protein complex assembly
is_a: GO:1904711 ! regulation of Wnt-Frizzled-LRP5/6 complex assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1904701 ! Wnt-Frizzled-LRP5/6 complex assembly
relationship: positively_regulates GO:1904701 ! Wnt-Frizzled-LRP5/6 complex assembly
created_by: bf
creation_date: 2015-10-05T14:02:35Z

[Term]
id: GO:1904713
name: beta-catenin destruction complex binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a beta-catenin destruction complex." [GO_REF:000102, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22899650]
synonym: "23S APC complex binding" NARROW [GOC:TermGenie]
synonym: "APC-Axin-1-beta-catenin complex binding" EXACT [GOC:TermGenie]
synonym: "Axin-APC-beta-catenin-GSK3B complex binding" EXACT [GOC:TermGenie]
synonym: "BDC binding" EXACT [PMID:22899650]
synonym: "beta-catenin degradation complex binding" EXACT [GOC:TermGenie]
is_a: GO:0032403 ! protein complex binding
created_by: bf
creation_date: 2015-10-05T14:34:14Z

[Term]
id: GO:1904714
name: regulation of chaperone-mediated autophagy
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chaperone-mediated autophagy." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20176123]
synonym: "regulation of CMA" RELATED [GOC:TermGenie]
is_a: GO:0010506 ! regulation of autophagy
is_a: GO:0051246 ! regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061684 ! chaperone-mediated autophagy
relationship: regulates GO:0061684 ! chaperone-mediated autophagy
created_by: pad
creation_date: 2015-10-06T08:49:02Z

[Term]
id: GO:1904715
name: negative regulation of chaperone-mediated autophagy
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chaperone-mediated autophagy." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20176123]
synonym: "down regulation of chaperone-mediated autophagy" EXACT [GOC:TermGenie]
synonym: "down regulation of CMA" RELATED [GOC:TermGenie]
synonym: "down-regulation of chaperone-mediated autophagy" EXACT [GOC:TermGenie]
synonym: "down-regulation of CMA" RELATED [GOC:TermGenie]
synonym: "downregulation of chaperone-mediated autophagy" EXACT [GOC:TermGenie]
synonym: "downregulation of CMA" RELATED [GOC:TermGenie]
synonym: "inhibition of chaperone-mediated autophagy" NARROW [GOC:TermGenie]
synonym: "inhibition of CMA" RELATED [GOC:TermGenie]
synonym: "negative regulation of CMA" RELATED [GOC:TermGenie]
is_a: GO:0010507 ! negative regulation of autophagy
is_a: GO:0051248 ! negative regulation of protein metabolic process
is_a: GO:1904714 ! regulation of chaperone-mediated autophagy
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061684 ! chaperone-mediated autophagy
relationship: negatively_regulates GO:0061684 ! chaperone-mediated autophagy
created_by: pad
creation_date: 2015-10-06T08:49:09Z

[Term]
id: GO:1904716
name: positive regulation of chaperone-mediated autophagy
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chaperone-mediated autophagy." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20176123]
synonym: "activation of chaperone-mediated autophagy" NARROW [GOC:TermGenie]
synonym: "activation of CMA" RELATED [GOC:TermGenie]
synonym: "positive regulation of CMA" RELATED [GOC:TermGenie]
synonym: "up regulation of chaperone-mediated autophagy" EXACT [GOC:TermGenie]
synonym: "up regulation of CMA" RELATED [GOC:TermGenie]
synonym: "up-regulation of chaperone-mediated autophagy" EXACT [GOC:TermGenie]
synonym: "up-regulation of CMA" RELATED [GOC:TermGenie]
synonym: "upregulation of chaperone-mediated autophagy" EXACT [GOC:TermGenie]
synonym: "upregulation of CMA" RELATED [GOC:TermGenie]
is_a: GO:0010508 ! positive regulation of autophagy
is_a: GO:0051247 ! positive regulation of protein metabolic process
is_a: GO:1904714 ! regulation of chaperone-mediated autophagy
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061684 ! chaperone-mediated autophagy
relationship: positively_regulates GO:0061684 ! chaperone-mediated autophagy
created_by: pad
creation_date: 2015-10-06T08:49:15Z

[Term]
id: GO:1904717
name: regulation of AMPA glutamate receptor clustering
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of AMPA glutamate receptor clustering." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:21558424]
synonym: "regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering" EXACT [GOC:TermGenie]
synonym: "regulation of AMPA receptor clustering" EXACT [GOC:TermGenie]
is_a: GO:0051963 ! regulation of synapse assembly
is_a: GO:1901626 ! regulation of postsynaptic membrane organization
is_a: GO:1903909 ! regulation of receptor clustering
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097113 ! AMPA glutamate receptor clustering
relationship: regulates GO:0097113 ! AMPA glutamate receptor clustering
created_by: hjd
creation_date: 2015-10-07T19:32:11Z

[Term]
id: GO:1904718
name: negative regulation of AMPA glutamate receptor clustering
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of AMPA glutamate receptor clustering." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:21558424]
synonym: "down regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering" EXACT [GOC:TermGenie]
synonym: "down regulation of AMPA glutamate receptor clustering" EXACT [GOC:TermGenie]
synonym: "down regulation of AMPA receptor clustering" EXACT [GOC:TermGenie]
synonym: "down-regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering" EXACT [GOC:TermGenie]
synonym: "down-regulation of AMPA glutamate receptor clustering" EXACT [GOC:TermGenie]
synonym: "down-regulation of AMPA receptor clustering" EXACT [GOC:TermGenie]
synonym: "downregulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering" EXACT [GOC:TermGenie]
synonym: "downregulation of AMPA glutamate receptor clustering" EXACT [GOC:TermGenie]
synonym: "downregulation of AMPA receptor clustering" EXACT [GOC:TermGenie]
synonym: "inhibition of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering" NARROW [GOC:TermGenie]
synonym: "inhibition of AMPA glutamate receptor clustering" NARROW [GOC:TermGenie]
synonym: "inhibition of AMPA receptor clustering" NARROW [GOC:TermGenie]
synonym: "negative regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering" EXACT [GOC:TermGenie]
synonym: "negative regulation of AMPA receptor clustering" EXACT [GOC:TermGenie]
is_a: GO:0051964 ! negative regulation of synapse assembly
is_a: GO:1901627 ! negative regulation of postsynaptic membrane organization
is_a: GO:1903910 ! negative regulation of receptor clustering
is_a: GO:1904717 ! regulation of AMPA glutamate receptor clustering
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097113 ! AMPA glutamate receptor clustering
relationship: negatively_regulates GO:0097113 ! AMPA glutamate receptor clustering
created_by: hjd
creation_date: 2015-10-07T19:32:28Z

[Term]
id: GO:1904719
name: positive regulation of AMPA glutamate receptor clustering
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of AMPA glutamate receptor clustering." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:21558424]
synonym: "activation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering" NARROW [GOC:TermGenie]
synonym: "activation of AMPA glutamate receptor clustering" NARROW [GOC:TermGenie]
synonym: "activation of AMPA receptor clustering" NARROW [GOC:TermGenie]
synonym: "positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering" EXACT [GOC:TermGenie]
synonym: "positive regulation of AMPA receptor clustering" EXACT [GOC:TermGenie]
synonym: "up regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering" EXACT [GOC:TermGenie]
synonym: "up regulation of AMPA glutamate receptor clustering" EXACT [GOC:TermGenie]
synonym: "up regulation of AMPA receptor clustering" EXACT [GOC:TermGenie]
synonym: "up-regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering" EXACT [GOC:TermGenie]
synonym: "up-regulation of AMPA glutamate receptor clustering" EXACT [GOC:TermGenie]
synonym: "up-regulation of AMPA receptor clustering" EXACT [GOC:TermGenie]
synonym: "upregulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering" EXACT [GOC:TermGenie]
synonym: "upregulation of AMPA glutamate receptor clustering" EXACT [GOC:TermGenie]
synonym: "upregulation of AMPA receptor clustering" EXACT [GOC:TermGenie]
is_a: GO:0051965 ! positive regulation of synapse assembly
is_a: GO:1901628 ! positive regulation of postsynaptic membrane organization
is_a: GO:1903911 ! positive regulation of receptor clustering
is_a: GO:1904717 ! regulation of AMPA glutamate receptor clustering
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097113 ! AMPA glutamate receptor clustering
relationship: positively_regulates GO:0097113 ! AMPA glutamate receptor clustering
created_by: hjd
creation_date: 2015-10-07T19:32:34Z

[Term]
id: GO:1904720
name: regulation of mRNA endonucleolytic cleavage involved in unfolded protein response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mRNA endonucleolytic cleavage involved in unfolded protein response." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19328063, PMID:20625543]
synonym: "regulation of HAC1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "regulation of HAC1-type intron splice site recognition and cleavage" NARROW [GOC:TermGenie]
synonym: "regulation of IRE1-mediated XBP-1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "regulation of XBP1 mRNA cleavage" NARROW [GOC:TermGenie]
is_a: GO:0031437 ! regulation of mRNA cleavage
is_a: GO:0043484 ! regulation of RNA splicing
is_a: GO:1903894 ! regulation of IRE1-mediated unfolded protein response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070055 ! mRNA endonucleolytic cleavage involved in unfolded protein response
relationship: regulates GO:0070055 ! mRNA endonucleolytic cleavage involved in unfolded protein response
created_by: bf
creation_date: 2015-10-08T14:52:49Z

[Term]
id: GO:1904721
name: negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA endonucleolytic cleavage involved in unfolded protein response." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19328063]
synonym: "down regulation of HAC1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "down regulation of HAC1-type intron splice site recognition and cleavage" NARROW [GOC:TermGenie]
synonym: "down regulation of IRE1-mediated XBP-1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "down regulation of mRNA endonucleolytic cleavage involved in unfolded protein response" EXACT [GOC:TermGenie]
synonym: "down regulation of XBP1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "down-regulation of HAC1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "down-regulation of HAC1-type intron splice site recognition and cleavage" NARROW [GOC:TermGenie]
synonym: "down-regulation of IRE1-mediated XBP-1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "down-regulation of mRNA endonucleolytic cleavage involved in unfolded protein response" EXACT [GOC:TermGenie]
synonym: "down-regulation of XBP1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "downregulation of HAC1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "downregulation of HAC1-type intron splice site recognition and cleavage" NARROW [GOC:TermGenie]
synonym: "downregulation of IRE1-mediated XBP-1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "downregulation of mRNA endonucleolytic cleavage involved in unfolded protein response" EXACT [GOC:TermGenie]
synonym: "downregulation of XBP1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "inhibition of HAC1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "inhibition of HAC1-type intron splice site recognition and cleavage" NARROW [GOC:TermGenie]
synonym: "inhibition of IRE1-mediated XBP-1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "inhibition of mRNA endonucleolytic cleavage involved in unfolded protein response" NARROW [GOC:TermGenie]
synonym: "inhibition of XBP1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "negative regulation of HAC1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "negative regulation of HAC1-type intron splice site recognition and cleavage" NARROW [GOC:TermGenie]
synonym: "negative regulation of IRE1-mediated XBP-1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "negative regulation of XBP1 mRNA cleavage" NARROW [GOC:TermGenie]
is_a: GO:0031438 ! negative regulation of mRNA cleavage
is_a: GO:0033119 ! negative regulation of RNA splicing
is_a: GO:1903895 ! negative regulation of IRE1-mediated unfolded protein response
is_a: GO:1904720 ! regulation of mRNA endonucleolytic cleavage involved in unfolded protein response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070055 ! mRNA endonucleolytic cleavage involved in unfolded protein response
relationship: negatively_regulates GO:0070055 ! mRNA endonucleolytic cleavage involved in unfolded protein response
created_by: bf
creation_date: 2015-10-08T14:52:55Z

[Term]
id: GO:1904722
name: positive regulation of mRNA endonucleolytic cleavage involved in unfolded protein response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mRNA endonucleolytic cleavage involved in unfolded protein response." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:20625543]
synonym: "activation of HAC1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "activation of HAC1-type intron splice site recognition and cleavage" NARROW [GOC:TermGenie]
synonym: "activation of IRE1-mediated XBP-1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "activation of mRNA endonucleolytic cleavage involved in unfolded protein response" NARROW [GOC:TermGenie]
synonym: "activation of XBP1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "positive regulation of HAC1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "positive regulation of HAC1-type intron splice site recognition and cleavage" NARROW [GOC:TermGenie]
synonym: "positive regulation of IRE1-mediated XBP-1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "positive regulation of XBP1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "up regulation of HAC1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "up regulation of HAC1-type intron splice site recognition and cleavage" NARROW [GOC:TermGenie]
synonym: "up regulation of IRE1-mediated XBP-1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "up regulation of mRNA endonucleolytic cleavage involved in unfolded protein response" EXACT [GOC:TermGenie]
synonym: "up regulation of XBP1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "up-regulation of HAC1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "up-regulation of HAC1-type intron splice site recognition and cleavage" NARROW [GOC:TermGenie]
synonym: "up-regulation of IRE1-mediated XBP-1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "up-regulation of mRNA endonucleolytic cleavage involved in unfolded protein response" EXACT [GOC:TermGenie]
synonym: "up-regulation of XBP1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "upregulation of HAC1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "upregulation of HAC1-type intron splice site recognition and cleavage" NARROW [GOC:TermGenie]
synonym: "upregulation of IRE1-mediated XBP-1 mRNA cleavage" NARROW [GOC:TermGenie]
synonym: "upregulation of mRNA endonucleolytic cleavage involved in unfolded protein response" EXACT [GOC:TermGenie]
synonym: "upregulation of XBP1 mRNA cleavage" NARROW [GOC:TermGenie]
is_a: GO:0031439 ! positive regulation of mRNA cleavage
is_a: GO:0033120 ! positive regulation of RNA splicing
is_a: GO:1903896 ! positive regulation of IRE1-mediated unfolded protein response
is_a: GO:1904720 ! regulation of mRNA endonucleolytic cleavage involved in unfolded protein response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070055 ! mRNA endonucleolytic cleavage involved in unfolded protein response
relationship: positively_regulates GO:0070055 ! mRNA endonucleolytic cleavage involved in unfolded protein response
created_by: bf
creation_date: 2015-10-08T14:53:02Z

[Term]
id: GO:1904723
name: negative regulation of Wnt-Frizzled-LRP5/6 complex assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of Wnt-Frizzled-LRP5/6 complex assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11433302]
synonym: "down regulation of Frizzled-LRP5/6 complex assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie]
synonym: "down regulation of WNT-FZD-LRP5 complex assembly" NARROW [GOC:TermGenie]
synonym: "down regulation of WNT-FZD-LRP5 complex formation" NARROW [GOC:TermGenie]
synonym: "down regulation of Wnt-FZD-LRP5/6 trimeric complex assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of Wnt-FZD-LRP5/6 trimeric complex formation" EXACT [GOC:TermGenie]
synonym: "down regulation of WNT-FZD-LRP6 complex assembly" NARROW [GOC:TermGenie]
synonym: "down regulation of WNT-FZD-LRP6 complex formation" NARROW [GOC:TermGenie]
synonym: "down regulation of Wnt-induced Frizzled-LRP5/6 complex assembly" RELATED [GOC:TermGenie]
synonym: "down regulation of Wnt-induced Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie]
synonym: "down-regulation of Frizzled-LRP5/6 complex assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie]
synonym: "down-regulation of WNT-FZD-LRP5 complex assembly" NARROW [GOC:TermGenie]
synonym: "down-regulation of WNT-FZD-LRP5 complex formation" NARROW [GOC:TermGenie]
synonym: "down-regulation of Wnt-FZD-LRP5/6 trimeric complex assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of Wnt-FZD-LRP5/6 trimeric complex formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of WNT-FZD-LRP6 complex assembly" NARROW [GOC:TermGenie]
synonym: "down-regulation of WNT-FZD-LRP6 complex formation" NARROW [GOC:TermGenie]
synonym: "down-regulation of Wnt-induced Frizzled-LRP5/6 complex assembly" RELATED [GOC:TermGenie]
synonym: "down-regulation of Wnt-induced Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie]
synonym: "downregulation of Frizzled-LRP5/6 complex assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie]
synonym: "downregulation of WNT-FZD-LRP5 complex assembly" NARROW [GOC:TermGenie]
synonym: "downregulation of WNT-FZD-LRP5 complex formation" NARROW [GOC:TermGenie]
synonym: "downregulation of Wnt-FZD-LRP5/6 trimeric complex assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of Wnt-FZD-LRP5/6 trimeric complex formation" EXACT [GOC:TermGenie]
synonym: "downregulation of WNT-FZD-LRP6 complex assembly" NARROW [GOC:TermGenie]
synonym: "downregulation of WNT-FZD-LRP6 complex formation" NARROW [GOC:TermGenie]
synonym: "downregulation of Wnt-induced Frizzled-LRP5/6 complex assembly" RELATED [GOC:TermGenie]
synonym: "downregulation of Wnt-induced Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie]
synonym: "inhibition of Frizzled-LRP5/6 complex assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie]
synonym: "inhibition of WNT-FZD-LRP5 complex assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of WNT-FZD-LRP5 complex formation" NARROW [GOC:TermGenie]
synonym: "inhibition of Wnt-FZD-LRP5/6 trimeric complex assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of Wnt-FZD-LRP5/6 trimeric complex formation" NARROW [GOC:TermGenie]
synonym: "inhibition of WNT-FZD-LRP6 complex assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of WNT-FZD-LRP6 complex formation" NARROW [GOC:TermGenie]
synonym: "inhibition of Wnt-induced Frizzled-LRP5/6 complex assembly" RELATED [GOC:TermGenie]
synonym: "inhibition of Wnt-induced Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie]
synonym: "negative regulation of Frizzled-LRP5/6 complex assembly" RELATED [GOC:bf]
synonym: "negative regulation of Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie]
synonym: "negative regulation of WNT-FZD-LRP5 complex assembly" NARROW [GOC:TermGenie]
synonym: "negative regulation of WNT-FZD-LRP5 complex formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of Wnt-FZD-LRP5/6 trimeric complex assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of Wnt-FZD-LRP5/6 trimeric complex formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of WNT-FZD-LRP6 complex assembly" NARROW [GOC:TermGenie]
synonym: "negative regulation of WNT-FZD-LRP6 complex formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of Wnt-induced Frizzled-LRP5/6 complex assembly" RELATED [GOC:TermGenie]
synonym: "negative regulation of Wnt-induced Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie]
is_a: GO:0031333 ! negative regulation of protein complex assembly
is_a: GO:1904711 ! regulation of Wnt-Frizzled-LRP5/6 complex assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1904701 ! Wnt-Frizzled-LRP5/6 complex assembly
relationship: negatively_regulates GO:1904701 ! Wnt-Frizzled-LRP5/6 complex assembly
created_by: bf
creation_date: 2015-10-12T08:14:59Z

[Term]
id: GO:1904724
name: tertiary granule lumen
namespace: cellular_component
def: "Any membrane-enclosed lumen that is part of a tertiary granule." [GO_REF:0000064, GOC:TermGenie, PMID:23650620]
synonym: "gelatinase granule membrane-enclosed lumen" RELATED []
synonym: "membrane-enclosed lumen of gelatinase granule" EXACT [GOC:TermGenie]
synonym: "membrane-enclosed lumen of tertiary granule" EXACT [GOC:TermGenie]
synonym: "tertiary granule membrane-enclosed lumen" EXACT []
is_a: GO:0031974 ! membrane-enclosed lumen
is_a: GO:0044433 ! cytoplasmic vesicle part
intersection_of: GO:0031974 ! membrane-enclosed lumen
intersection_of: part_of GO:0070820 ! tertiary granule
relationship: part_of GO:0070820 ! tertiary granule
created_by: mec
creation_date: 2015-10-12T12:53:10Z

[Term]
id: GO:1904725
name: TFIIB-class transcription factor binding involved in negative regulation of transcription
namespace: molecular_function
def: "Any TFIIB-class transcription factor binding that is involved in negative regulation of DNA-templated transcription." [GO_REF:0000061, GOC:rb, GOC:TermGenie, PMID:12461786]
synonym: "TFIIB-class transcription factor binding involved in down regulation of gene-specific transcription" RELATED [GOC:TermGenie]
synonym: "TFIIB-class transcription factor binding involved in down regulation of transcription, DNA-dependent" EXACT [GOC:TermGenie]
synonym: "TFIIB-class transcription factor binding involved in down-regulation of gene-specific transcription" RELATED [GOC:TermGenie]
synonym: "TFIIB-class transcription factor binding involved in down-regulation of transcription, DNA-dependent" EXACT [GOC:TermGenie]
synonym: "TFIIB-class transcription factor binding involved in downregulation of gene-specific transcription" RELATED [GOC:TermGenie]
synonym: "TFIIB-class transcription factor binding involved in downregulation of transcription, DNA-dependent" EXACT [GOC:TermGenie]
synonym: "TFIIB-class transcription factor binding involved in inhibition of gene-specific transcription" RELATED [GOC:TermGenie]
synonym: "TFIIB-class transcription factor binding involved in inhibition of transcription, DNA-dependent" NARROW [GOC:TermGenie]
synonym: "TFIIB-class transcription factor binding involved in negative regulation of cellular transcription, DNA-dependent" EXACT [GOC:TermGenie]
synonym: "TFIIB-class transcription factor binding involved in negative regulation of gene-specific transcription" RELATED [GOC:TermGenie]
synonym: "TFIIB-class transcription factor binding involved in negative regulation of transcription, DNA-dependent" EXACT [GOC:TermGenie]
synonym: "TFIIB-class transcription factor binding involved in negative regulation of transcription, DNA-templated" EXACT []
synonym: "TFIIB-class transcription factor binding involved in transcription repressor activity" RELATED [GOC:TermGenie]
is_a: GO:0001093 ! TFIIB-class transcription factor binding
intersection_of: GO:0001093 ! TFIIB-class transcription factor binding
intersection_of: part_of GO:0045892 ! negative regulation of transcription, DNA-templated
relationship: part_of GO:0045892 ! negative regulation of transcription, DNA-templated
created_by: tb
creation_date: 2015-10-13T19:49:39Z

[Term]
id: GO:1904726
name: regulation of replicative senescence
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of replicative senescence." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23496142]
is_a: GO:0090342 ! regulation of cell aging
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0090399 ! replicative senescence
relationship: regulates GO:0090399 ! replicative senescence
created_by: rph
creation_date: 2015-10-14T13:11:24Z

[Term]
id: GO:1904727
name: negative regulation of replicative senescence
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of replicative senescence." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23496142]
synonym: "down regulation of replicative senescence" EXACT [GOC:TermGenie]
synonym: "down-regulation of replicative senescence" EXACT [GOC:TermGenie]
synonym: "downregulation of replicative senescence" EXACT [GOC:TermGenie]
synonym: "inhibition of replicative senescence" NARROW [GOC:TermGenie]
is_a: GO:0090344 ! negative regulation of cell aging
is_a: GO:1904726 ! regulation of replicative senescence
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0090399 ! replicative senescence
relationship: negatively_regulates GO:0090399 ! replicative senescence
created_by: rph
creation_date: 2015-10-14T13:11:31Z

[Term]
id: GO:1904728
name: positive regulation of replicative senescence
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of replicative senescence." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23496142]
synonym: "activation of replicative senescence" NARROW [GOC:TermGenie]
synonym: "up regulation of replicative senescence" EXACT [GOC:TermGenie]
synonym: "up-regulation of replicative senescence" EXACT [GOC:TermGenie]
synonym: "upregulation of replicative senescence" EXACT [GOC:TermGenie]
is_a: GO:0090343 ! positive regulation of cell aging
is_a: GO:1904726 ! regulation of replicative senescence
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0090399 ! replicative senescence
relationship: positively_regulates GO:0090399 ! replicative senescence
created_by: rph
creation_date: 2015-10-14T13:11:37Z

[Term]
id: GO:1904729
name: regulation of intestinal lipid absorption
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of intestinal lipid absorption." [GO_REF:0000058, GOC:TermGenie, PMID:18768481]
is_a: GO:0032368 ! regulation of lipid transport
is_a: GO:1904478 ! regulation of intestinal absorption
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0098856 ! intestinal lipid absorption
relationship: regulates GO:0098856 ! intestinal lipid absorption
created_by: sl
creation_date: 2015-10-14T15:24:56Z

[Term]
id: GO:1904730
name: negative regulation of intestinal lipid absorption
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of intestinal lipid absorption." [GO_REF:0000058, GOC:TermGenie, PMID:18768481]
synonym: "down regulation of intestinal lipid absorption" EXACT [GOC:TermGenie]
synonym: "down-regulation of intestinal lipid absorption" EXACT [GOC:TermGenie]
synonym: "downregulation of intestinal lipid absorption" EXACT [GOC:TermGenie]
synonym: "inhibition of intestinal lipid absorption" NARROW [GOC:TermGenie]
is_a: GO:0032369 ! negative regulation of lipid transport
is_a: GO:1904479 ! negative regulation of intestinal absorption
is_a: GO:1904729 ! regulation of intestinal lipid absorption
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0098856 ! intestinal lipid absorption
relationship: negatively_regulates GO:0098856 ! intestinal lipid absorption
created_by: sl
creation_date: 2015-10-14T15:25:03Z

[Term]
id: GO:1904731
name: positive regulation of intestinal lipid absorption
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of intestinal lipid absorption." [GO_REF:0000058, GOC:TermGenie, PMID:18768481]
synonym: "activation of intestinal lipid absorption" NARROW [GOC:TermGenie]
synonym: "up regulation of intestinal lipid absorption" EXACT [GOC:TermGenie]
synonym: "up-regulation of intestinal lipid absorption" EXACT [GOC:TermGenie]
synonym: "upregulation of intestinal lipid absorption" EXACT [GOC:TermGenie]
is_a: GO:0032370 ! positive regulation of lipid transport
is_a: GO:1904480 ! positive regulation of intestinal absorption
is_a: GO:1904729 ! regulation of intestinal lipid absorption
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0098856 ! intestinal lipid absorption
relationship: positively_regulates GO:0098856 ! intestinal lipid absorption
created_by: sl
creation_date: 2015-10-14T15:25:10Z

[Term]
id: GO:1904732
name: regulation of electron carrier activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of electron carrier activity." [GO_REF:0000059, GOC:TermGenie, PMID:25416781]
synonym: "regulation of 2Fe-2S electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "regulation of 3Fe-4S/4Fe-4S electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "regulation of adrenodoxin-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "regulation of amicyanin" NARROW [GOC:TermGenie]
synonym: "regulation of azurin" NARROW [GOC:TermGenie]
synonym: "regulation of bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "regulation of chloroplast-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "regulation of copper electron carrier" NARROW [GOC:TermGenie]
synonym: "regulation of dicluster bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "regulation of electron acceptor activity" NARROW [GOC:TermGenie]
synonym: "regulation of electron carrier, chlorophyll electron transport system" RELATED [GOC:TermGenie]
synonym: "regulation of electron donor activity" NARROW [GOC:TermGenie]
synonym: "regulation of electron transfer flavoprotein" NARROW [GOC:TermGenie]
synonym: "regulation of electron transfer flavoprotein, group I" NARROW [GOC:TermGenie]
synonym: "regulation of electron transfer flavoprotein, group II" NARROW [GOC:TermGenie]
synonym: "regulation of electron transporter activity" EXACT [GOC:TermGenie]
synonym: "regulation of high-potential iron-sulfur carrier" NARROW [GOC:TermGenie]
synonym: "regulation of iron-sulfur electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "regulation of monocluster bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "regulation of mononuclear iron electron carrier" NARROW [GOC:TermGenie]
synonym: "regulation of polyferredoxin" NARROW [GOC:TermGenie]
synonym: "regulation of redox-active disulfide bond electron carrier" NARROW [GOC:TermGenie]
synonym: "regulation of rubredoxin" NARROW [GOC:TermGenie]
synonym: "regulation of small blue copper electron carrier" NARROW [GOC:TermGenie]
synonym: "regulation of thioredoxin-like 2Fe-2S ferredoxin" NARROW [GOC:TermGenie]
is_a: GO:0065009 ! regulation of molecular function
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009055 ! electron carrier activity
relationship: regulates GO:0009055 ! electron carrier activity
created_by: lb
creation_date: 2015-10-15T07:51:19Z

[Term]
id: GO:1904733
name: negative regulation of electron carrier activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of electron carrier activity." [GO_REF:0000059, GOC:TermGenie, PMID:25416781]
synonym: "down regulation of 2Fe-2S electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "down regulation of 3Fe-4S/4Fe-4S electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "down regulation of adrenodoxin-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "down regulation of amicyanin" NARROW [GOC:TermGenie]
synonym: "down regulation of azurin" NARROW [GOC:TermGenie]
synonym: "down regulation of bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "down regulation of chloroplast-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "down regulation of copper electron carrier" NARROW [GOC:TermGenie]
synonym: "down regulation of dicluster bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "down regulation of electron acceptor activity" NARROW [GOC:TermGenie]
synonym: "down regulation of electron carrier activity" EXACT [GOC:TermGenie]
synonym: "down regulation of electron carrier, chlorophyll electron transport system" RELATED [GOC:TermGenie]
synonym: "down regulation of electron donor activity" NARROW [GOC:TermGenie]
synonym: "down regulation of electron transfer flavoprotein" NARROW [GOC:TermGenie]
synonym: "down regulation of electron transfer flavoprotein, group I" NARROW [GOC:TermGenie]
synonym: "down regulation of electron transfer flavoprotein, group II" NARROW [GOC:TermGenie]
synonym: "down regulation of electron transporter activity" EXACT [GOC:TermGenie]
synonym: "down regulation of high-potential iron-sulfur carrier" NARROW [GOC:TermGenie]
synonym: "down regulation of iron-sulfur electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "down regulation of monocluster bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "down regulation of mononuclear iron electron carrier" NARROW [GOC:TermGenie]
synonym: "down regulation of polyferredoxin" NARROW [GOC:TermGenie]
synonym: "down regulation of redox-active disulfide bond electron carrier" NARROW [GOC:TermGenie]
synonym: "down regulation of rubredoxin" NARROW [GOC:TermGenie]
synonym: "down regulation of small blue copper electron carrier" NARROW [GOC:TermGenie]
synonym: "down regulation of thioredoxin-like 2Fe-2S ferredoxin" NARROW [GOC:TermGenie]
synonym: "down-regulation of 2Fe-2S electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "down-regulation of 3Fe-4S/4Fe-4S electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "down-regulation of adrenodoxin-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "down-regulation of amicyanin" NARROW [GOC:TermGenie]
synonym: "down-regulation of azurin" NARROW [GOC:TermGenie]
synonym: "down-regulation of bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "down-regulation of chloroplast-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "down-regulation of copper electron carrier" NARROW [GOC:TermGenie]
synonym: "down-regulation of dicluster bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "down-regulation of electron acceptor activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of electron carrier activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of electron carrier, chlorophyll electron transport system" RELATED [GOC:TermGenie]
synonym: "down-regulation of electron donor activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of electron transfer flavoprotein" NARROW [GOC:TermGenie]
synonym: "down-regulation of electron transfer flavoprotein, group I" NARROW [GOC:TermGenie]
synonym: "down-regulation of electron transfer flavoprotein, group II" NARROW [GOC:TermGenie]
synonym: "down-regulation of electron transporter activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of high-potential iron-sulfur carrier" NARROW [GOC:TermGenie]
synonym: "down-regulation of iron-sulfur electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "down-regulation of monocluster bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "down-regulation of mononuclear iron electron carrier" NARROW [GOC:TermGenie]
synonym: "down-regulation of polyferredoxin" NARROW [GOC:TermGenie]
synonym: "down-regulation of redox-active disulfide bond electron carrier" NARROW [GOC:TermGenie]
synonym: "down-regulation of rubredoxin" NARROW [GOC:TermGenie]
synonym: "down-regulation of small blue copper electron carrier" NARROW [GOC:TermGenie]
synonym: "down-regulation of thioredoxin-like 2Fe-2S ferredoxin" NARROW [GOC:TermGenie]
synonym: "downregulation of 2Fe-2S electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "downregulation of 3Fe-4S/4Fe-4S electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "downregulation of adrenodoxin-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "downregulation of amicyanin" NARROW [GOC:TermGenie]
synonym: "downregulation of azurin" NARROW [GOC:TermGenie]
synonym: "downregulation of bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "downregulation of chloroplast-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "downregulation of copper electron carrier" NARROW [GOC:TermGenie]
synonym: "downregulation of dicluster bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "downregulation of electron acceptor activity" NARROW [GOC:TermGenie]
synonym: "downregulation of electron carrier activity" EXACT [GOC:TermGenie]
synonym: "downregulation of electron carrier, chlorophyll electron transport system" RELATED [GOC:TermGenie]
synonym: "downregulation of electron donor activity" NARROW [GOC:TermGenie]
synonym: "downregulation of electron transfer flavoprotein" NARROW [GOC:TermGenie]
synonym: "downregulation of electron transfer flavoprotein, group I" NARROW [GOC:TermGenie]
synonym: "downregulation of electron transfer flavoprotein, group II" NARROW [GOC:TermGenie]
synonym: "downregulation of electron transporter activity" EXACT [GOC:TermGenie]
synonym: "downregulation of high-potential iron-sulfur carrier" NARROW [GOC:TermGenie]
synonym: "downregulation of iron-sulfur electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "downregulation of monocluster bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "downregulation of mononuclear iron electron carrier" NARROW [GOC:TermGenie]
synonym: "downregulation of polyferredoxin" NARROW [GOC:TermGenie]
synonym: "downregulation of redox-active disulfide bond electron carrier" NARROW [GOC:TermGenie]
synonym: "downregulation of rubredoxin" NARROW [GOC:TermGenie]
synonym: "downregulation of small blue copper electron carrier" NARROW [GOC:TermGenie]
synonym: "downregulation of thioredoxin-like 2Fe-2S ferredoxin" NARROW [GOC:TermGenie]
synonym: "inhibition of 2Fe-2S electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "inhibition of 3Fe-4S/4Fe-4S electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "inhibition of adrenodoxin-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "inhibition of amicyanin" NARROW [GOC:TermGenie]
synonym: "inhibition of azurin" NARROW [GOC:TermGenie]
synonym: "inhibition of bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "inhibition of chloroplast-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "inhibition of copper electron carrier" NARROW [GOC:TermGenie]
synonym: "inhibition of dicluster bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "inhibition of electron acceptor activity" NARROW [GOC:TermGenie]
synonym: "inhibition of electron carrier activity" NARROW [GOC:TermGenie]
synonym: "inhibition of electron carrier, chlorophyll electron transport system" RELATED [GOC:TermGenie]
synonym: "inhibition of electron donor activity" NARROW [GOC:TermGenie]
synonym: "inhibition of electron transfer flavoprotein" NARROW [GOC:TermGenie]
synonym: "inhibition of electron transfer flavoprotein, group I" NARROW [GOC:TermGenie]
synonym: "inhibition of electron transfer flavoprotein, group II" NARROW [GOC:TermGenie]
synonym: "inhibition of electron transporter activity" NARROW [GOC:TermGenie]
synonym: "inhibition of high-potential iron-sulfur carrier" NARROW [GOC:TermGenie]
synonym: "inhibition of iron-sulfur electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "inhibition of monocluster bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "inhibition of mononuclear iron electron carrier" NARROW [GOC:TermGenie]
synonym: "inhibition of polyferredoxin" NARROW [GOC:TermGenie]
synonym: "inhibition of redox-active disulfide bond electron carrier" NARROW [GOC:TermGenie]
synonym: "inhibition of rubredoxin" NARROW [GOC:TermGenie]
synonym: "inhibition of small blue copper electron carrier" NARROW [GOC:TermGenie]
synonym: "inhibition of thioredoxin-like 2Fe-2S ferredoxin" NARROW [GOC:TermGenie]
synonym: "negative regulation of 2Fe-2S electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "negative regulation of 3Fe-4S/4Fe-4S electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "negative regulation of adrenodoxin-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "negative regulation of amicyanin" NARROW [GOC:TermGenie]
synonym: "negative regulation of azurin" NARROW [GOC:TermGenie]
synonym: "negative regulation of bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "negative regulation of chloroplast-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "negative regulation of copper electron carrier" NARROW [GOC:TermGenie]
synonym: "negative regulation of dicluster bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "negative regulation of electron acceptor activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of electron carrier, chlorophyll electron transport system" RELATED [GOC:TermGenie]
synonym: "negative regulation of electron donor activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of electron transfer flavoprotein" NARROW [GOC:TermGenie]
synonym: "negative regulation of electron transfer flavoprotein, group I" NARROW [GOC:TermGenie]
synonym: "negative regulation of electron transfer flavoprotein, group II" NARROW [GOC:TermGenie]
synonym: "negative regulation of electron transporter activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of high-potential iron-sulfur carrier" NARROW [GOC:TermGenie]
synonym: "negative regulation of iron-sulfur electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "negative regulation of monocluster bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "negative regulation of mononuclear iron electron carrier" NARROW [GOC:TermGenie]
synonym: "negative regulation of polyferredoxin" NARROW [GOC:TermGenie]
synonym: "negative regulation of redox-active disulfide bond electron carrier" NARROW [GOC:TermGenie]
synonym: "negative regulation of rubredoxin" NARROW [GOC:TermGenie]
synonym: "negative regulation of small blue copper electron carrier" NARROW [GOC:TermGenie]
synonym: "negative regulation of thioredoxin-like 2Fe-2S ferredoxin" NARROW [GOC:TermGenie]
is_a: GO:0044092 ! negative regulation of molecular function
is_a: GO:1904732 ! regulation of electron carrier activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009055 ! electron carrier activity
relationship: negatively_regulates GO:0009055 ! electron carrier activity
created_by: lb
creation_date: 2015-10-15T07:51:26Z

[Term]
id: GO:1904734
name: positive regulation of electron carrier activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of electron carrier activity." [GO_REF:0000059, GOC:TermGenie, PMID:25416781]
synonym: "activation of 2Fe-2S electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "activation of 3Fe-4S/4Fe-4S electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "activation of adrenodoxin-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "activation of amicyanin" NARROW [GOC:TermGenie]
synonym: "activation of azurin" NARROW [GOC:TermGenie]
synonym: "activation of bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "activation of chloroplast-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "activation of copper electron carrier" NARROW [GOC:TermGenie]
synonym: "activation of dicluster bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "activation of electron acceptor activity" NARROW [GOC:TermGenie]
synonym: "activation of electron carrier activity" NARROW [GOC:TermGenie]
synonym: "activation of electron carrier, chlorophyll electron transport system" RELATED [GOC:TermGenie]
synonym: "activation of electron donor activity" NARROW [GOC:TermGenie]
synonym: "activation of electron transfer flavoprotein" NARROW [GOC:TermGenie]
synonym: "activation of electron transfer flavoprotein, group I" NARROW [GOC:TermGenie]
synonym: "activation of electron transfer flavoprotein, group II" NARROW [GOC:TermGenie]
synonym: "activation of electron transporter activity" NARROW [GOC:TermGenie]
synonym: "activation of high-potential iron-sulfur carrier" NARROW [GOC:TermGenie]
synonym: "activation of iron-sulfur electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "activation of monocluster bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "activation of mononuclear iron electron carrier" NARROW [GOC:TermGenie]
synonym: "activation of polyferredoxin" NARROW [GOC:TermGenie]
synonym: "activation of redox-active disulfide bond electron carrier" NARROW [GOC:TermGenie]
synonym: "activation of rubredoxin" NARROW [GOC:TermGenie]
synonym: "activation of small blue copper electron carrier" NARROW [GOC:TermGenie]
synonym: "activation of thioredoxin-like 2Fe-2S ferredoxin" NARROW [GOC:TermGenie]
synonym: "positive regulation of 2Fe-2S electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "positive regulation of 3Fe-4S/4Fe-4S electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "positive regulation of adrenodoxin-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "positive regulation of amicyanin" NARROW [GOC:TermGenie]
synonym: "positive regulation of azurin" NARROW [GOC:TermGenie]
synonym: "positive regulation of bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "positive regulation of chloroplast-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "positive regulation of copper electron carrier" NARROW [GOC:TermGenie]
synonym: "positive regulation of dicluster bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "positive regulation of electron acceptor activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of electron carrier, chlorophyll electron transport system" RELATED [GOC:TermGenie]
synonym: "positive regulation of electron donor activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of electron transfer flavoprotein" NARROW [GOC:TermGenie]
synonym: "positive regulation of electron transfer flavoprotein, group I" NARROW [GOC:TermGenie]
synonym: "positive regulation of electron transfer flavoprotein, group II" NARROW [GOC:TermGenie]
synonym: "positive regulation of electron transporter activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of high-potential iron-sulfur carrier" NARROW [GOC:TermGenie]
synonym: "positive regulation of iron-sulfur electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "positive regulation of monocluster bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "positive regulation of mononuclear iron electron carrier" NARROW [GOC:TermGenie]
synonym: "positive regulation of polyferredoxin" NARROW [GOC:TermGenie]
synonym: "positive regulation of redox-active disulfide bond electron carrier" NARROW [GOC:TermGenie]
synonym: "positive regulation of rubredoxin" NARROW [GOC:TermGenie]
synonym: "positive regulation of small blue copper electron carrier" NARROW [GOC:TermGenie]
synonym: "positive regulation of thioredoxin-like 2Fe-2S ferredoxin" NARROW [GOC:TermGenie]
synonym: "up regulation of 2Fe-2S electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "up regulation of 3Fe-4S/4Fe-4S electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "up regulation of adrenodoxin-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "up regulation of amicyanin" NARROW [GOC:TermGenie]
synonym: "up regulation of azurin" NARROW [GOC:TermGenie]
synonym: "up regulation of bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "up regulation of chloroplast-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "up regulation of copper electron carrier" NARROW [GOC:TermGenie]
synonym: "up regulation of dicluster bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "up regulation of electron acceptor activity" NARROW [GOC:TermGenie]
synonym: "up regulation of electron carrier activity" EXACT [GOC:TermGenie]
synonym: "up regulation of electron carrier, chlorophyll electron transport system" RELATED [GOC:TermGenie]
synonym: "up regulation of electron donor activity" NARROW [GOC:TermGenie]
synonym: "up regulation of electron transfer flavoprotein" NARROW [GOC:TermGenie]
synonym: "up regulation of electron transfer flavoprotein, group I" NARROW [GOC:TermGenie]
synonym: "up regulation of electron transfer flavoprotein, group II" NARROW [GOC:TermGenie]
synonym: "up regulation of electron transporter activity" EXACT [GOC:TermGenie]
synonym: "up regulation of high-potential iron-sulfur carrier" NARROW [GOC:TermGenie]
synonym: "up regulation of iron-sulfur electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "up regulation of monocluster bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "up regulation of mononuclear iron electron carrier" NARROW [GOC:TermGenie]
synonym: "up regulation of polyferredoxin" NARROW [GOC:TermGenie]
synonym: "up regulation of redox-active disulfide bond electron carrier" NARROW [GOC:TermGenie]
synonym: "up regulation of rubredoxin" NARROW [GOC:TermGenie]
synonym: "up regulation of small blue copper electron carrier" NARROW [GOC:TermGenie]
synonym: "up regulation of thioredoxin-like 2Fe-2S ferredoxin" NARROW [GOC:TermGenie]
synonym: "up-regulation of 2Fe-2S electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "up-regulation of 3Fe-4S/4Fe-4S electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "up-regulation of adrenodoxin-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "up-regulation of amicyanin" NARROW [GOC:TermGenie]
synonym: "up-regulation of azurin" NARROW [GOC:TermGenie]
synonym: "up-regulation of bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "up-regulation of chloroplast-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "up-regulation of copper electron carrier" NARROW [GOC:TermGenie]
synonym: "up-regulation of dicluster bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "up-regulation of electron acceptor activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of electron carrier activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of electron carrier, chlorophyll electron transport system" RELATED [GOC:TermGenie]
synonym: "up-regulation of electron donor activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of electron transfer flavoprotein" NARROW [GOC:TermGenie]
synonym: "up-regulation of electron transfer flavoprotein, group I" NARROW [GOC:TermGenie]
synonym: "up-regulation of electron transfer flavoprotein, group II" NARROW [GOC:TermGenie]
synonym: "up-regulation of electron transporter activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of high-potential iron-sulfur carrier" NARROW [GOC:TermGenie]
synonym: "up-regulation of iron-sulfur electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "up-regulation of monocluster bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "up-regulation of mononuclear iron electron carrier" NARROW [GOC:TermGenie]
synonym: "up-regulation of polyferredoxin" NARROW [GOC:TermGenie]
synonym: "up-regulation of redox-active disulfide bond electron carrier" NARROW [GOC:TermGenie]
synonym: "up-regulation of rubredoxin" NARROW [GOC:TermGenie]
synonym: "up-regulation of small blue copper electron carrier" NARROW [GOC:TermGenie]
synonym: "up-regulation of thioredoxin-like 2Fe-2S ferredoxin" NARROW [GOC:TermGenie]
synonym: "upregulation of 2Fe-2S electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "upregulation of 3Fe-4S/4Fe-4S electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "upregulation of adrenodoxin-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "upregulation of amicyanin" NARROW [GOC:TermGenie]
synonym: "upregulation of azurin" NARROW [GOC:TermGenie]
synonym: "upregulation of bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "upregulation of chloroplast-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "upregulation of copper electron carrier" NARROW [GOC:TermGenie]
synonym: "upregulation of dicluster bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "upregulation of electron acceptor activity" NARROW [GOC:TermGenie]
synonym: "upregulation of electron carrier activity" EXACT [GOC:TermGenie]
synonym: "upregulation of electron carrier, chlorophyll electron transport system" RELATED [GOC:TermGenie]
synonym: "upregulation of electron donor activity" NARROW [GOC:TermGenie]
synonym: "upregulation of electron transfer flavoprotein" NARROW [GOC:TermGenie]
synonym: "upregulation of electron transfer flavoprotein, group I" NARROW [GOC:TermGenie]
synonym: "upregulation of electron transfer flavoprotein, group II" NARROW [GOC:TermGenie]
synonym: "upregulation of electron transporter activity" EXACT [GOC:TermGenie]
synonym: "upregulation of high-potential iron-sulfur carrier" NARROW [GOC:TermGenie]
synonym: "upregulation of iron-sulfur electron transfer carrier" NARROW [GOC:TermGenie]
synonym: "upregulation of monocluster bacterial-type ferredoxin" NARROW [GOC:TermGenie]
synonym: "upregulation of mononuclear iron electron carrier" NARROW [GOC:TermGenie]
synonym: "upregulation of polyferredoxin" NARROW [GOC:TermGenie]
synonym: "upregulation of redox-active disulfide bond electron carrier" NARROW [GOC:TermGenie]
synonym: "upregulation of rubredoxin" NARROW [GOC:TermGenie]
synonym: "upregulation of small blue copper electron carrier" NARROW [GOC:TermGenie]
synonym: "upregulation of thioredoxin-like 2Fe-2S ferredoxin" NARROW [GOC:TermGenie]
is_a: GO:0044093 ! positive regulation of molecular function
is_a: GO:1904732 ! regulation of electron carrier activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009055 ! electron carrier activity
relationship: positively_regulates GO:0009055 ! electron carrier activity
created_by: lb
creation_date: 2015-10-15T07:51:32Z

[Term]
id: GO:1904735
name: regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fatty acid beta-oxidation using acyl-CoA dehydrogenase." [GO_REF:0000058, GOC:TermGenie, PMID:25416781]
is_a: GO:0031998 ! regulation of fatty acid beta-oxidation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0033539 ! fatty acid beta-oxidation using acyl-CoA dehydrogenase
relationship: regulates GO:0033539 ! fatty acid beta-oxidation using acyl-CoA dehydrogenase
created_by: lb
creation_date: 2015-10-15T08:14:51Z

[Term]
id: GO:1904736
name: negative regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of fatty acid beta-oxidation using acyl-CoA dehydrogenase." [GO_REF:0000058, GOC:TermGenie, PMID:25416781]
synonym: "down regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase" EXACT [GOC:TermGenie]
synonym: "down-regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase" EXACT [GOC:TermGenie]
synonym: "downregulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase" EXACT [GOC:TermGenie]
synonym: "inhibition of fatty acid beta-oxidation using acyl-CoA dehydrogenase" NARROW [GOC:TermGenie]
is_a: GO:0031999 ! negative regulation of fatty acid beta-oxidation
is_a: GO:1904735 ! regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0033539 ! fatty acid beta-oxidation using acyl-CoA dehydrogenase
relationship: negatively_regulates GO:0033539 ! fatty acid beta-oxidation using acyl-CoA dehydrogenase
created_by: lb
creation_date: 2015-10-15T08:14:57Z

[Term]
id: GO:1904737
name: positive regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of fatty acid beta-oxidation using acyl-CoA dehydrogenase." [GO_REF:0000058, GOC:TermGenie, PMID:25416781]
synonym: "activation of fatty acid beta-oxidation using acyl-CoA dehydrogenase" NARROW [GOC:TermGenie]
synonym: "up regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase" EXACT [GOC:TermGenie]
synonym: "up-regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase" EXACT [GOC:TermGenie]
synonym: "upregulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase" EXACT [GOC:TermGenie]
is_a: GO:0032000 ! positive regulation of fatty acid beta-oxidation
is_a: GO:1904735 ! regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0033539 ! fatty acid beta-oxidation using acyl-CoA dehydrogenase
relationship: positively_regulates GO:0033539 ! fatty acid beta-oxidation using acyl-CoA dehydrogenase
created_by: lb
creation_date: 2015-10-15T08:15:03Z

[Term]
id: GO:1904738
name: vascular associated smooth muscle cell migration
namespace: biological_process
def: "The orderly movement of a vascular associated smooth muscle cell from one site to another." [GO_REF:0000091, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20693317]
synonym: "vascular smooth muscle cell migration" EXACT []
is_a: GO:0014909 ! smooth muscle cell migration
created_by: rph
creation_date: 2015-10-15T09:56:00Z

[Term]
id: GO:1904739
name: regulation of synapse organization by posttranscriptional regulation of gene expression
namespace: biological_process
def: "A posttranscriptional regulation of gene expression that results in regulation of synapse organization." [GO_REF:0000063, GOC:rb, GOC:TermGenie, PMID:20729808]
synonym: "regulation of synapse development by posttranscriptional regulation of gene expression" EXACT [GOC:TermGenie]
synonym: "regulation of synapse morphogenesis by posttranscriptional regulation of gene expression" RELATED [GOC:TermGenie]
synonym: "regulation of synapse organisation by posttranscriptional regulation of gene expression" EXACT [GOC:TermGenie]
synonym: "regulation of synapse organization and biogenesis by posttranscriptional regulation of gene expression" RELATED [GOC:TermGenie]
is_a: GO:0010608 ! posttranscriptional regulation of gene expression
is_a: GO:0050807 ! regulation of synapse organization
intersection_of: GO:0010608 ! posttranscriptional regulation of gene expression
intersection_of: regulates GO:0050808 ! synapse organization
relationship: regulates GO:0050808 ! synapse organization
created_by: tb
creation_date: 2015-10-15T21:25:46Z

[Term]
id: GO:1904740
name: positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by transcription from RNA polymerase II promoter
namespace: biological_process
def: "A transcription from RNA polymerase II promoter that results in positive regulation of filamentous growth of a population of unicellular organisms in response to starvation." [GO_REF:0000063, GOC:rn, GOC:TermGenie, PMID:26448198]
synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by gene-specific transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by general transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by RNA polymerase II transcription factor activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by specific transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by transcription from Pol II promoter" EXACT [GOC:TermGenie]
is_a: GO:0006366 ! transcription from RNA polymerase II promoter
is_a: GO:1900436 ! positive regulation of filamentous growth of a population of unicellular organisms in response to starvation
intersection_of: GO:0006366 ! transcription from RNA polymerase II promoter
intersection_of: positively_regulates GO:0036170 ! filamentous growth of a population of unicellular organisms in response to starvation
relationship: positively_regulates GO:0036170 ! filamentous growth of a population of unicellular organisms in response to starvation
created_by: tb
creation_date: 2015-10-15T21:30:51Z

[Term]
id: GO:1904741
name: positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A positive regulation of transcription from RNA polymerase II promoter that results in positive regulation of filamentous growth of a population of unicellular organisms in response to starvation." [GO_REF:0000063, GOC:rn, GOC:TermGenie, PMID:26448198]
synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by activation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by activation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by positive regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by positive regulation of global transcription from Pol II promoter" RELATED [GOC:TermGenie]
synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by positive regulation of transcription from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by positive regulation of transcription from RNA polymerase II promoter, global" RELATED [GOC:TermGenie]
synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by stimulation of global transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie]
synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by up regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by up-regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by upregulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie]
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
is_a: GO:1900436 ! positive regulation of filamentous growth of a population of unicellular organisms in response to starvation
intersection_of: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
intersection_of: positively_regulates GO:0036170 ! filamentous growth of a population of unicellular organisms in response to starvation
relationship: positively_regulates GO:0036170 ! filamentous growth of a population of unicellular organisms in response to starvation
created_by: tb
creation_date: 2015-10-15T21:40:43Z

[Term]
id: GO:1904742
name: regulation of telomeric DNA binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of telomeric DNA binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24415760]
synonym: "regulation of telomere binding" EXACT [GOC:TermGenie]
synonym: "regulation of telomeric repeat binding" EXACT [GOC:TermGenie]
is_a: GO:0051101 ! regulation of DNA binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042162 ! telomeric DNA binding
relationship: regulates GO:0042162 ! telomeric DNA binding
created_by: nc
creation_date: 2015-10-19T12:18:48Z

[Term]
id: GO:1904743
name: negative regulation of telomeric DNA binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of telomeric DNA binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24415760]
synonym: "down regulation of telomere binding" EXACT [GOC:TermGenie]
synonym: "down regulation of telomeric DNA binding" EXACT [GOC:TermGenie]
synonym: "down regulation of telomeric repeat binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of telomere binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of telomeric DNA binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of telomeric repeat binding" EXACT [GOC:TermGenie]
synonym: "downregulation of telomere binding" EXACT [GOC:TermGenie]
synonym: "downregulation of telomeric DNA binding" EXACT [GOC:TermGenie]
synonym: "downregulation of telomeric repeat binding" EXACT [GOC:TermGenie]
synonym: "inhibition of telomere binding" NARROW [GOC:TermGenie]
synonym: "inhibition of telomeric DNA binding" NARROW [GOC:TermGenie]
synonym: "inhibition of telomeric repeat binding" NARROW [GOC:TermGenie]
synonym: "negative regulation of telomere binding" EXACT [GOC:TermGenie]
synonym: "negative regulation of telomeric repeat binding" EXACT [GOC:TermGenie]
is_a: GO:0043392 ! negative regulation of DNA binding
is_a: GO:1904742 ! regulation of telomeric DNA binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042162 ! telomeric DNA binding
relationship: negatively_regulates GO:0042162 ! telomeric DNA binding
created_by: nc
creation_date: 2015-10-19T12:18:55Z

[Term]
id: GO:1904744
name: positive regulation of telomeric DNA binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of telomeric DNA binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24415760]
synonym: "activation of telomere binding" NARROW [GOC:TermGenie]
synonym: "activation of telomeric DNA binding" NARROW [GOC:TermGenie]
synonym: "activation of telomeric repeat binding" NARROW [GOC:TermGenie]
synonym: "positive regulation of telomere binding" EXACT [GOC:TermGenie]
synonym: "positive regulation of telomeric repeat binding" EXACT [GOC:TermGenie]
synonym: "up regulation of telomere binding" EXACT [GOC:TermGenie]
synonym: "up regulation of telomeric DNA binding" EXACT [GOC:TermGenie]
synonym: "up regulation of telomeric repeat binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of telomere binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of telomeric DNA binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of telomeric repeat binding" EXACT [GOC:TermGenie]
synonym: "upregulation of telomere binding" EXACT [GOC:TermGenie]
synonym: "upregulation of telomeric DNA binding" EXACT [GOC:TermGenie]
synonym: "upregulation of telomeric repeat binding" EXACT [GOC:TermGenie]
is_a: GO:0043388 ! positive regulation of DNA binding
is_a: GO:1904742 ! regulation of telomeric DNA binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042162 ! telomeric DNA binding
relationship: positively_regulates GO:0042162 ! telomeric DNA binding
created_by: nc
creation_date: 2015-10-19T12:19:01Z

[Term]
id: GO:1904745
name: ATG1/ULK1 kinase complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an ATG1/UKL1 kinase complex." [GO_REF:0000079, GOC:dph, GOC:TermGenie, PMID:25139988]
synonym: "ATG1 kinase complex assembly" EXACT [GOC:TermGenie]
synonym: "ATG1 kinase complex formation" EXACT [GOC:TermGenie]
synonym: "ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie]
synonym: "ATG1-ATG13 complex formation" EXACT [GOC:TermGenie]
synonym: "ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie]
synonym: "ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie]
synonym: "ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie]
synonym: "Atg1p signalling complex assembly" EXACT [GOC:TermGenie]
synonym: "Atg1p signalling complex formation" EXACT [GOC:TermGenie]
synonym: "ULK1 signaling complex assembly" EXACT [GOC:TermGenie]
synonym: "ULK1 signaling complex formation" EXACT [GOC:TermGenie]
synonym: "ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie]
synonym: "ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie]
synonym: "ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie]
synonym: "ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie]
is_a: GO:0006461 ! protein complex assembly
created_by: dph
creation_date: 2015-10-19T12:33:08Z

[Term]
id: GO:1904746
name: negative regulation of apoptotic process involved in development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in development." [GO_REF:0000058, GOC:TermGenie, PMID:22801495]
comment: U4PR86 in PMID:22801495 inferred from mutant phenotype
synonym: "down regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "down regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "down regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "down regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "down regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "down regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "down regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "down regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "down regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "down regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "down regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "down regulation of apoptotic process involved in development" EXACT [GOC:TermGenie]
synonym: "down regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "down regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "down regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "down regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "down regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "down regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "down regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "down regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "down regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "down regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "down regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "down regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "down regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "down regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "down regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "down regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "down regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "down-regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "down-regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "down-regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "down-regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptotic process involved in development" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "down-regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "down-regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "down-regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "down-regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "down-regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "down-regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "down-regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "down-regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "down-regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "down-regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "down-regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "down-regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "downregulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "downregulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "downregulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "downregulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptotic process involved in development" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "downregulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "downregulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "downregulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "downregulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "downregulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "downregulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "downregulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "downregulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "downregulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "downregulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "downregulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "downregulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "inhibition of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "inhibition of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "inhibition of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "inhibition of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic process involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic process involved in development" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic process involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "inhibition of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "inhibition of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "inhibition of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "inhibition of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "inhibition of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "inhibition of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "inhibition of programmed cell death by apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "inhibition of programmed cell death by apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "inhibition of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "inhibition of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "inhibition of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "inhibition of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "negative regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "negative regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "negative regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "negative regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "negative regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "negative regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "negative regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "negative regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "negative regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "negative regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "negative regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "negative regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "negative regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "negative regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "negative regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "negative regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "negative regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "negative regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "negative regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "negative regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "negative regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
is_a: GO:0043066 ! negative regulation of apoptotic process
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:1904748 ! regulation of apoptotic process involved in development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1902742 ! apoptotic process involved in development
relationship: negatively_regulates GO:1902742 ! apoptotic process involved in development
created_by: es
creation_date: 2015-10-19T14:12:27Z

[Term]
id: GO:1904747
name: positive regulation of apoptotic process involved in development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in development." [GO_REF:0000058, GOC:TermGenie, PMID:22801495]
comment: U4PR86 in PMID:22801495 inferred from mutant phenotype
synonym: "activation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "activation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "activation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "activation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "activation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "activation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic process involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic process involved in development" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic process involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "activation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "activation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "activation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "activation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "activation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "activation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "activation of programmed cell death by apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "activation of programmed cell death by apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "activation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "activation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "activation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "activation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "positive regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "positive regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "positive regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "positive regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "positive regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "positive regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "positive regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "positive regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "positive regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "positive regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "positive regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "positive regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "positive regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "positive regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "positive regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "positive regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "positive regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "positive regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "positive regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "positive regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "positive regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "up regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "up regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "up regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "up regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptotic process involved in development" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "up regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "up regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "up regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "up regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "up regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "up regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "up regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "up regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "up regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "up regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "up regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "up regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "up-regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "up-regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "up-regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "up-regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptotic process involved in development" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "up-regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "up-regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "up-regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "up-regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "up-regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "up-regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "up-regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "up-regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "up-regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "up-regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "up-regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "up-regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "upregulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "upregulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "upregulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "upregulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptotic process involved in development" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "upregulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "upregulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "upregulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "upregulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "upregulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "upregulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "upregulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "upregulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "upregulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "upregulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "upregulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "upregulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
is_a: GO:0043065 ! positive regulation of apoptotic process
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:1904748 ! regulation of apoptotic process involved in development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1902742 ! apoptotic process involved in development
relationship: positively_regulates GO:1902742 ! apoptotic process involved in development
created_by: es
creation_date: 2015-10-19T14:12:34Z

[Term]
id: GO:1904748
name: regulation of apoptotic process involved in development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of apoptotic process involved in development." [GO_REF:0000058, GOC:TermGenie, PMID:22801495]
comment: Q10943 in PMID:22801495, inferred from mutant phenotype
synonym: "regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
is_a: GO:0042981 ! regulation of apoptotic process
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1902742 ! apoptotic process involved in development
relationship: regulates GO:1902742 ! apoptotic process involved in development
created_by: es
creation_date: 2015-10-19T15:02:28Z

[Term]
id: GO:1904749
name: regulation of protein localization to nucleolus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to nucleolus." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24415760]
synonym: "regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie]
synonym: "regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie]
synonym: "regulation of protein localization in nucleolus" EXACT [GOC:TermGenie]
is_a: GO:1900180 ! regulation of protein localization to nucleus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1902570 ! protein localization to nucleolus
relationship: regulates GO:1902570 ! protein localization to nucleolus
created_by: nc
creation_date: 2015-10-19T15:16:17Z

[Term]
id: GO:1904750
name: negative regulation of protein localization to nucleolus
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleolus." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24415760]
synonym: "down regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization in nucleolus" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to nucleolus" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization in nucleolus" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to nucleolus" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation in nucleolus" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation to nucleolus" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization in nucleolus" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to nucleolus" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localisation in nucleolus" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localisation to nucleolus" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization in nucleolus" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to nucleolus" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localization in nucleolus" EXACT [GOC:TermGenie]
is_a: GO:1900181 ! negative regulation of protein localization to nucleus
is_a: GO:1904749 ! regulation of protein localization to nucleolus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1902570 ! protein localization to nucleolus
relationship: negatively_regulates GO:1902570 ! protein localization to nucleolus
created_by: nc
creation_date: 2015-10-19T15:16:24Z

[Term]
id: GO:1904751
name: positive regulation of protein localization to nucleolus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to nucleolus." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24415760]
synonym: "activation of protein localisation in nucleolus" NARROW [GOC:TermGenie]
synonym: "activation of protein localisation to nucleolus" NARROW [GOC:TermGenie]
synonym: "activation of protein localization in nucleolus" NARROW [GOC:TermGenie]
synonym: "activation of protein localization to nucleolus" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localization in nucleolus" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization in nucleolus" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to nucleolus" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization in nucleolus" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to nucleolus" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation in nucleolus" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation to nucleolus" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization in nucleolus" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to nucleolus" EXACT [GOC:TermGenie]
is_a: GO:1900182 ! positive regulation of protein localization to nucleus
is_a: GO:1904749 ! regulation of protein localization to nucleolus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1902570 ! protein localization to nucleolus
relationship: positively_regulates GO:1902570 ! protein localization to nucleolus
created_by: nc
creation_date: 2015-10-19T15:16:30Z

[Term]
id: GO:1904752
name: regulation of vascular associated smooth muscle cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vascular associated smooth muscle cell migration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20693317]
synonym: "regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie]
is_a: GO:0014910 ! regulation of smooth muscle cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1904738 ! vascular associated smooth muscle cell migration
relationship: regulates GO:1904738 ! vascular associated smooth muscle cell migration
created_by: rph
creation_date: 2015-10-19T15:49:52Z

[Term]
id: GO:1904753
name: negative regulation of vascular associated smooth muscle cell migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell migration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20693317]
synonym: "down regulation of vascular associated smooth muscle cell migration" EXACT [GOC:TermGenie]
synonym: "down regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie]
synonym: "down-regulation of vascular associated smooth muscle cell migration" EXACT [GOC:TermGenie]
synonym: "down-regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie]
synonym: "downregulation of vascular associated smooth muscle cell migration" EXACT [GOC:TermGenie]
synonym: "downregulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie]
synonym: "inhibition of vascular associated smooth muscle cell migration" NARROW [GOC:TermGenie]
synonym: "inhibition of vascular smooth muscle cell migration" NARROW [GOC:TermGenie]
synonym: "negative regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie]
is_a: GO:0014912 ! negative regulation of smooth muscle cell migration
is_a: GO:1904752 ! regulation of vascular associated smooth muscle cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1904738 ! vascular associated smooth muscle cell migration
relationship: negatively_regulates GO:1904738 ! vascular associated smooth muscle cell migration
created_by: rph
creation_date: 2015-10-19T15:49:58Z

[Term]
id: GO:1904754
name: positive regulation of vascular associated smooth muscle cell migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell migration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20693317]
synonym: "activation of vascular associated smooth muscle cell migration" NARROW [GOC:TermGenie]
synonym: "activation of vascular smooth muscle cell migration" NARROW [GOC:TermGenie]
synonym: "positive regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie]
synonym: "up regulation of vascular associated smooth muscle cell migration" EXACT [GOC:TermGenie]
synonym: "up regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie]
synonym: "up-regulation of vascular associated smooth muscle cell migration" EXACT [GOC:TermGenie]
synonym: "up-regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie]
synonym: "upregulation of vascular associated smooth muscle cell migration" EXACT [GOC:TermGenie]
synonym: "upregulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie]
is_a: GO:0014911 ! positive regulation of smooth muscle cell migration
is_a: GO:1904752 ! regulation of vascular associated smooth muscle cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1904738 ! vascular associated smooth muscle cell migration
relationship: positively_regulates GO:1904738 ! vascular associated smooth muscle cell migration
created_by: rph
creation_date: 2015-10-19T15:50:05Z

[Term]
id: GO:1904755
name: regulation of gut granule assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gut granule assembly." [GO_REF:0000058, GOC:TermGenie, PMID:17535251]
synonym: "regulation of gut granule biogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of gut granule formation" EXACT [GOC:TermGenie]
is_a: GO:1902115 ! regulation of organelle assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1902900 ! gut granule assembly
relationship: regulates GO:1902900 ! gut granule assembly
created_by: ah
creation_date: 2015-10-21T08:43:44Z

[Term]
id: GO:1904756
name: negative regulation of gut granule assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of gut granule assembly." [GO_REF:0000058, GOC:TermGenie, PMID:17535251]
synonym: "down regulation of gut granule assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of gut granule biogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of gut granule formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of gut granule assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of gut granule biogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of gut granule formation" EXACT [GOC:TermGenie]
synonym: "downregulation of gut granule assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of gut granule biogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of gut granule formation" EXACT [GOC:TermGenie]
synonym: "inhibition of gut granule assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of gut granule biogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of gut granule formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of gut granule biogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of gut granule formation" EXACT [GOC:TermGenie]
is_a: GO:1902116 ! negative regulation of organelle assembly
is_a: GO:1904755 ! regulation of gut granule assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1902900 ! gut granule assembly
relationship: negatively_regulates GO:1902900 ! gut granule assembly
created_by: ah
creation_date: 2015-10-21T08:43:51Z

[Term]
id: GO:1904757
name: positive regulation of gut granule assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of gut granule assembly." [GO_REF:0000058, GOC:TermGenie, PMID:17535251]
synonym: "activation of gut granule assembly" NARROW [GOC:TermGenie]
synonym: "activation of gut granule biogenesis" NARROW [GOC:TermGenie]
synonym: "activation of gut granule formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of gut granule biogenesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of gut granule formation" EXACT [GOC:TermGenie]
synonym: "up regulation of gut granule assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of gut granule biogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of gut granule formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of gut granule assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of gut granule biogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of gut granule formation" EXACT [GOC:TermGenie]
synonym: "upregulation of gut granule assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of gut granule biogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of gut granule formation" EXACT [GOC:TermGenie]
is_a: GO:1902117 ! positive regulation of organelle assembly
is_a: GO:1904755 ! regulation of gut granule assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1902900 ! gut granule assembly
relationship: positively_regulates GO:1902900 ! gut granule assembly
created_by: ah
creation_date: 2015-10-21T08:43:57Z

[Term]
id: GO:1904758
name: protein localization to new growing cell tip
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a new growing cell tip." [GO_REF:0000087, GOC:TermGenie, PMID:19431238]
synonym: "protein localisation in new growing cell tip" EXACT [GOC:TermGenie]
synonym: "protein localisation to new growing cell tip" EXACT [GOC:TermGenie]
synonym: "protein localization in new growing cell tip" EXACT [GOC:TermGenie]
synonym: "protein localization to new cell tip after activation of bipolar cell growth" EXACT []
synonym: "protein localization to new growing cell end" EXACT []
synonym: "protein localization to post-NETO new cell end" EXACT []
synonym: "protein localization to post-NETO new cell tip" EXACT []
synonym: "protein localization to post-new end take-off new cell tip" EXACT []
is_a: GO:1902486 ! protein localization to growing cell tip
created_by: mah
creation_date: 2015-10-21T12:37:48Z

[Term]
id: GO:1904759
name: protein localization to equatorial microtubule organizing center
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within an equatorial microtubule organizing center." [GO_REF:0000087, GOC:TermGenie, PMID:16611237]
synonym: "protein localisation in equatorial microtubule organizing center" EXACT [GOC:TermGenie]
synonym: "protein localisation to equatorial microtubule organizing center" EXACT [GOC:TermGenie]
synonym: "protein localization in equatorial microtubule organizing center" EXACT [GOC:TermGenie]
synonym: "protein localization to eMTOC" EXACT []
is_a: GO:0072698 ! protein localization to microtubule cytoskeleton
is_a: GO:0072741 ! protein localization to cell division site
created_by: mah
creation_date: 2015-10-21T12:37:55Z

[Term]
id: GO:1904760
name: regulation of myofibroblast differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of myofibroblast differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20533548]
synonym: "regulation of myofibroblast cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045595 ! regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0036446 ! myofibroblast differentiation
relationship: regulates GO:0036446 ! myofibroblast differentiation
created_by: rph
creation_date: 2015-10-23T12:15:05Z

[Term]
id: GO:1904761
name: negative regulation of myofibroblast differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of myofibroblast differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20533548]
synonym: "down regulation of myofibroblast cell differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of myofibroblast differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of myofibroblast cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of myofibroblast differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of myofibroblast cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of myofibroblast differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of myofibroblast cell differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of myofibroblast differentiation" NARROW [GOC:TermGenie]
synonym: "negative regulation of myofibroblast cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:1904760 ! regulation of myofibroblast differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0036446 ! myofibroblast differentiation
relationship: negatively_regulates GO:0036446 ! myofibroblast differentiation
created_by: rph
creation_date: 2015-10-23T12:15:11Z

[Term]
id: GO:1904762
name: positive regulation of myofibroblast differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of myofibroblast differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20533548]
synonym: "activation of myofibroblast cell differentiation" NARROW [GOC:TermGenie]
synonym: "activation of myofibroblast differentiation" NARROW [GOC:TermGenie]
synonym: "positive regulation of myofibroblast cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of myofibroblast cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of myofibroblast differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of myofibroblast cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of myofibroblast differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of myofibroblast cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of myofibroblast differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:1904760 ! regulation of myofibroblast differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0036446 ! myofibroblast differentiation
relationship: positively_regulates GO:0036446 ! myofibroblast differentiation
created_by: rph
creation_date: 2015-10-23T12:15:17Z

[Term]
id: GO:1904763
name: chaperone-mediated autophagy translocation complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a chaperone-mediated autophagy translocation complex." [GO_REF:0000079, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:18644871]
synonym: "chaperone-mediated autophagy receptor complex assembly" RELATED [GOC:TermGenie]
synonym: "chaperone-mediated autophagy receptor complex formation" RELATED [GOC:TermGenie]
synonym: "chaperone-mediated autophagy translocation complex formation" EXACT [GOC:TermGenie]
synonym: "CMA receptor complex assembly" RELATED [GOC:TermGenie]
synonym: "CMA receptor complex formation" RELATED [GOC:TermGenie]
synonym: "CMA translocation complex assembly" EXACT [GOC:TermGenie]
synonym: "CMA translocation complex formation" EXACT [GOC:TermGenie]
is_a: GO:0006461 ! protein complex assembly
created_by: pad
creation_date: 2015-10-26T16:34:29Z

[Term]
id: GO:1904764
name: chaperone-mediated autophagy translocation complex disassembly
namespace: biological_process
def: "The disaggregation of a chaperone-mediated autophagy translocation complex into its constituent components." [GO_REF:0000079, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:18644871]
synonym: "chaperone-mediated autophagy receptor complex disassembly" RELATED [GOC:TermGenie]
synonym: "CMA receptor complex disassembly" RELATED [GOC:TermGenie]
synonym: "CMA translocation complex disassembly" EXACT [GOC:TermGenie]
is_a: GO:0043241 ! protein complex disassembly
created_by: pad
creation_date: 2015-10-26T16:34:36Z

[Term]
id: GO:1904765
name: positive regulation of transcription from RNA polymerase II promoter in response to maltose
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a maltose stimulus." [GO_REF:0000060, GOC:TermGenie, PMID:24224056]
synonym: "activation of global transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus" RELATED [GOC:TermGenie]
synonym: "activation of transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus" EXACT [GOC:TermGenie]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus" RELATED [GOC:TermGenie]
synonym: "positive regulation of global transcription from Pol II promoter involved in cellular response to maltose stimulus" RELATED [GOC:TermGenie]
synonym: "positive regulation of transcription from Pol II promoter involved in cellular response to maltose stimulus" EXACT [GOC:TermGenie]
synonym: "positive regulation of transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus" EXACT []
synonym: "positive regulation of transcription from RNA polymerase II promoter, global involved in cellular response to maltose stimulus" RELATED [GOC:TermGenie]
synonym: "stimulation of global transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus" NARROW [GOC:TermGenie]
synonym: "stimulation of transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus" EXACT [GOC:TermGenie]
synonym: "up regulation of global transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus" RELATED [GOC:TermGenie]
synonym: "up regulation of transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus" EXACT [GOC:TermGenie]
synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus" RELATED [GOC:TermGenie]
synonym: "up-regulation of transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus" EXACT [GOC:TermGenie]
synonym: "upregulation of global transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus" RELATED [GOC:TermGenie]
synonym: "upregulation of transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus" EXACT [GOC:TermGenie]
is_a: GO:1901522 ! positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
intersection_of: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
intersection_of: part_of GO:0071328 ! cellular response to maltose stimulus
relationship: part_of GO:0071328 ! cellular response to maltose stimulus
created_by: mah
creation_date: 2015-10-26T16:42:15Z

[Term]
id: GO:1904766
name: negative regulation of macroautophagy by TORC1 signaling
namespace: biological_process
def: "A TORC1 signaling that results in negative regulation of macroautophagy." [GO_REF:0000063, GOC:autophagy, GOC:dph, GOC:TermGenie, PMID:23602450]
synonym: "negative regulation of autophagy in response to cellular starvation by TORC1 signal transduction" EXACT [GOC:TermGenie]
synonym: "negative regulation of autophagy in response to cellular starvation by TORC1 signaling" EXACT [GOC:TermGenie]
synonym: "negative regulation of macroautophagy by TORC1 signal transduction" EXACT [GOC:TermGenie]
synonym: "negative regulation of non-specific autophagy by TORC1 signal transduction" EXACT [GOC:TermGenie]
synonym: "negative regulation of non-specific autophagy by TORC1 signaling" EXACT [GOC:TermGenie]
synonym: "negative regulation of starvation-induced autophagy by TORC1 signal transduction" EXACT [GOC:TermGenie]
synonym: "negative regulation of starvation-induced autophagy by TORC1 signaling" EXACT [GOC:TermGenie]
is_a: GO:0016242 ! negative regulation of macroautophagy
is_a: GO:0038202 ! TORC1 signaling
intersection_of: GO:0038202 ! TORC1 signaling
intersection_of: negatively_regulates GO:0016236 ! macroautophagy
relationship: negatively_regulates GO:0016236 ! macroautophagy
created_by: dph
creation_date: 2015-10-26T18:34:47Z

[Term]
id: GO:1904767
name: octanoic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with octanoic acid." [GO_REF:0000067, GOC:kmv, GOC:TermGenie, PMID:19828452]
synonym: "caprylic acid binding" EXACT [CHEBI:28837]
is_a: GO:0005504 ! fatty acid binding
created_by: kmv
creation_date: 2015-10-27T21:11:49Z

[Term]
id: GO:1904768
name: all-trans-retinol binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with all-trans-retinol." [GO_REF:0000067, GOC:kmv, GOC:TermGenie, PMID:19828452]
is_a: GO:0019841 ! retinol binding
created_by: kmv
creation_date: 2015-10-27T21:14:47Z

[Term]
id: GO:1904769
name: isopentadecanoic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with isopentadecanoic acid." [GO_REF:0000067, GOC:kmv, GOC:TermGenie, PMID:19828452]
synonym: "13-methylmyristic acid binding" EXACT [CHEBI:39250]
is_a: GO:0036041 ! long-chain fatty acid binding
created_by: kmv
creation_date: 2015-10-27T21:33:38Z

[Term]
id: GO:1904770
name: intramembranous bone morphogenesis
namespace: biological_process
def: "The developmental process by which an intramembranous bone is generated and organized." [GO_REF:0000083, GOC:TermGenie, PMID:26399686]
synonym: "intramembranous bones morphogenesis" RELATED [GOC:TermGenie]
synonym: "membrane bone morphogenesis" RELATED [GOC:TermGenie]
is_a: GO:0060349 ! bone morphogenesis
created_by: dos
creation_date: 2015-10-28T11:46:04Z

[Term]
id: GO:1904771
name: obsolete cellular response to doxorubicin
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a doxorubicin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:19801496]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
is_obsolete: true
created_by: sl
creation_date: 2015-10-28T20:48:30Z

[Term]
id: GO:1904772
name: response to tetrachloromethane
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetrachloromethane stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:7852267]
synonym: "response to carbon tetrachloride" EXACT []
synonym: "response to CCL4" EXACT []
is_a: GO:0010033 ! response to organic substance
created_by: sl
creation_date: 2015-10-28T20:59:15Z

[Term]
id: GO:1904773
name: obsolete cellular response to tetrachloromethane
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetrachloromethane stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:7852267]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "cellular response to carbon tetrachloride" EXACT []
synonym: "cellular response to CCL4" EXACT []
is_obsolete: true
created_by: sl
creation_date: 2015-10-28T20:59:21Z

[Term]
id: GO:1904774
name: negative regulation of ubiquinone biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ubiquinone biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:8125303]
synonym: "down regulation of coenzyme Q biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of coenzyme Q biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of coenzyme Q10 biosynthesis" NARROW [GOC:TermGenie]
synonym: "down regulation of coenzyme Q10 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "down regulation of coenzyme Q6 biosynthesis" NARROW [GOC:TermGenie]
synonym: "down regulation of coenzyme Q6 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "down regulation of coenzyme Q8 biosynthesis" NARROW [GOC:TermGenie]
synonym: "down regulation of coenzyme Q8 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "down regulation of coenzyme Q9 biosynthesis" NARROW [GOC:TermGenie]
synonym: "down regulation of coenzyme Q9 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "down regulation of ubiquinone anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of ubiquinone biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of ubiquinone biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of ubiquinone formation" EXACT [GOC:TermGenie]
synonym: "down regulation of ubiquinone synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of coenzyme Q biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of coenzyme Q biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of coenzyme Q10 biosynthesis" NARROW [GOC:TermGenie]
synonym: "down-regulation of coenzyme Q10 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "down-regulation of coenzyme Q6 biosynthesis" NARROW [GOC:TermGenie]
synonym: "down-regulation of coenzyme Q6 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "down-regulation of coenzyme Q8 biosynthesis" NARROW [GOC:TermGenie]
synonym: "down-regulation of coenzyme Q8 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "down-regulation of coenzyme Q9 biosynthesis" NARROW [GOC:TermGenie]
synonym: "down-regulation of coenzyme Q9 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "down-regulation of ubiquinone anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of ubiquinone biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of ubiquinone biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of ubiquinone formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of ubiquinone synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of coenzyme Q biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of coenzyme Q biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of coenzyme Q10 biosynthesis" NARROW [GOC:TermGenie]
synonym: "downregulation of coenzyme Q10 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "downregulation of coenzyme Q6 biosynthesis" NARROW [GOC:TermGenie]
synonym: "downregulation of coenzyme Q6 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "downregulation of coenzyme Q8 biosynthesis" NARROW [GOC:TermGenie]
synonym: "downregulation of coenzyme Q8 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "downregulation of coenzyme Q9 biosynthesis" NARROW [GOC:TermGenie]
synonym: "downregulation of coenzyme Q9 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "downregulation of ubiquinone anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of ubiquinone biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of ubiquinone biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of ubiquinone formation" EXACT [GOC:TermGenie]
synonym: "downregulation of ubiquinone synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of coenzyme Q biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of coenzyme Q biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of coenzyme Q10 biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of coenzyme Q10 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of coenzyme Q6 biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of coenzyme Q6 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of coenzyme Q8 biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of coenzyme Q8 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of coenzyme Q9 biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of coenzyme Q9 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of ubiquinone anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of ubiquinone biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of ubiquinone biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of ubiquinone formation" NARROW [GOC:TermGenie]
synonym: "inhibition of ubiquinone synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of coenzyme Q biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of coenzyme Q biosynthetic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of coenzyme Q10 biosynthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of coenzyme Q10 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of coenzyme Q6 biosynthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of coenzyme Q6 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of coenzyme Q8 biosynthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of coenzyme Q8 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of coenzyme Q9 biosynthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of coenzyme Q9 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of ubiquinone anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of ubiquinone biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of ubiquinone formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of ubiquinone synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010795 ! regulation of ubiquinone biosynthetic process
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0051198 ! negative regulation of coenzyme metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006744 ! ubiquinone biosynthetic process
relationship: negatively_regulates GO:0006744 ! ubiquinone biosynthetic process
created_by: sl
creation_date: 2015-10-28T21:21:20Z

[Term]
id: GO:1904775
name: positive regulation of ubiquinone biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ubiquinone biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:8125303]
synonym: "activation of coenzyme Q biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of coenzyme Q biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of coenzyme Q10 biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of coenzyme Q10 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of coenzyme Q6 biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of coenzyme Q6 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of coenzyme Q8 biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of coenzyme Q8 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of coenzyme Q9 biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of coenzyme Q9 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of ubiquinone anabolism" NARROW [GOC:TermGenie]
synonym: "activation of ubiquinone biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of ubiquinone biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of ubiquinone formation" NARROW [GOC:TermGenie]
synonym: "activation of ubiquinone synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of coenzyme Q biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of coenzyme Q biosynthetic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of coenzyme Q10 biosynthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of coenzyme Q10 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of coenzyme Q6 biosynthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of coenzyme Q6 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of coenzyme Q8 biosynthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of coenzyme Q8 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of coenzyme Q9 biosynthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of coenzyme Q9 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of ubiquinone anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of ubiquinone biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of ubiquinone formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of ubiquinone synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of coenzyme Q biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of coenzyme Q biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of coenzyme Q10 biosynthesis" NARROW [GOC:TermGenie]
synonym: "up regulation of coenzyme Q10 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "up regulation of coenzyme Q6 biosynthesis" NARROW [GOC:TermGenie]
synonym: "up regulation of coenzyme Q6 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "up regulation of coenzyme Q8 biosynthesis" NARROW [GOC:TermGenie]
synonym: "up regulation of coenzyme Q8 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "up regulation of coenzyme Q9 biosynthesis" NARROW [GOC:TermGenie]
synonym: "up regulation of coenzyme Q9 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "up regulation of ubiquinone anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of ubiquinone biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of ubiquinone biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of ubiquinone formation" EXACT [GOC:TermGenie]
synonym: "up regulation of ubiquinone synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of coenzyme Q biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of coenzyme Q biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of coenzyme Q10 biosynthesis" NARROW [GOC:TermGenie]
synonym: "up-regulation of coenzyme Q10 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "up-regulation of coenzyme Q6 biosynthesis" NARROW [GOC:TermGenie]
synonym: "up-regulation of coenzyme Q6 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "up-regulation of coenzyme Q8 biosynthesis" NARROW [GOC:TermGenie]
synonym: "up-regulation of coenzyme Q8 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "up-regulation of coenzyme Q9 biosynthesis" NARROW [GOC:TermGenie]
synonym: "up-regulation of coenzyme Q9 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "up-regulation of ubiquinone anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of ubiquinone biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of ubiquinone biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of ubiquinone formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of ubiquinone synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of coenzyme Q biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of coenzyme Q biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of coenzyme Q10 biosynthesis" NARROW [GOC:TermGenie]
synonym: "upregulation of coenzyme Q10 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "upregulation of coenzyme Q6 biosynthesis" NARROW [GOC:TermGenie]
synonym: "upregulation of coenzyme Q6 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "upregulation of coenzyme Q8 biosynthesis" NARROW [GOC:TermGenie]
synonym: "upregulation of coenzyme Q8 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "upregulation of coenzyme Q9 biosynthesis" NARROW [GOC:TermGenie]
synonym: "upregulation of coenzyme Q9 biosynthetic process" NARROW [GOC:TermGenie]
synonym: "upregulation of ubiquinone anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of ubiquinone biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of ubiquinone biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of ubiquinone formation" EXACT [GOC:TermGenie]
synonym: "upregulation of ubiquinone synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010795 ! regulation of ubiquinone biosynthetic process
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0051197 ! positive regulation of coenzyme metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006744 ! ubiquinone biosynthetic process
relationship: positively_regulates GO:0006744 ! ubiquinone biosynthetic process
created_by: sl
creation_date: 2015-10-28T21:21:26Z

[Term]
id: GO:1904776
name: regulation of protein localization to cell cortex
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to cell cortex." [GO_REF:0000058, GOC:TermGenie, PMID:17115027]
comment: An example is cye-1 in C. elegans, UniProt ID O01501 in PMID:17115027.
synonym: "regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie]
is_a: GO:1904375 ! regulation of protein localization to cell periphery
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072697 ! protein localization to cell cortex
relationship: regulates GO:0072697 ! protein localization to cell cortex
created_by: es
creation_date: 2015-10-29T16:55:01Z

[Term]
id: GO:1904777
name: negative regulation of protein localization to cell cortex
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell cortex." [GO_REF:0000058, GOC:TermGenie, PMID:17115027]
comment: An example is cye-1 in C. elegans, UniProt ID O01501 in PMID:17115027.
synonym: "down regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to cell cortex" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to cell cortex" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation to cell cortex" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to cell cortex" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localisation to cell cortex" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to cell cortex" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie]
is_a: GO:1904376 ! negative regulation of protein localization to cell periphery
is_a: GO:1904776 ! regulation of protein localization to cell cortex
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072697 ! protein localization to cell cortex
relationship: negatively_regulates GO:0072697 ! protein localization to cell cortex
created_by: es
creation_date: 2015-10-29T16:55:08Z

[Term]
id: GO:1904778
name: positive regulation of protein localization to cell cortex
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to cell cortex." [GO_REF:0000058, GOC:TermGenie, PMID:17115027]
comment: An example is cye-1 in C. elegans, UniProt ID O01501 in PMID:17115027.
synonym: "activation of protein localisation to cell cortex" NARROW [GOC:TermGenie]
synonym: "activation of protein localization to cell cortex" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to cell cortex" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to cell cortex" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation to cell cortex" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to cell cortex" EXACT [GOC:TermGenie]
is_a: GO:1904377 ! positive regulation of protein localization to cell periphery
is_a: GO:1904776 ! regulation of protein localization to cell cortex
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072697 ! protein localization to cell cortex
relationship: positively_regulates GO:0072697 ! protein localization to cell cortex
created_by: es
creation_date: 2015-10-29T16:55:15Z

[Term]
id: GO:1904779
name: regulation of protein localization to centrosome
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to centrosome." [GO_REF:0000058, GOC:TermGenie, PMID:17115027]
comment: An example is cdk-2 in C. elegans (UniProt ID O61847) in PMID:17115027 (inferred from mutant phenotype).
synonym: "regulation of protein localisation to centrosome" EXACT [GOC:TermGenie]
is_a: GO:1903827 ! regulation of cellular protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071539 ! protein localization to centrosome
relationship: regulates GO:0071539 ! protein localization to centrosome
created_by: es
creation_date: 2015-10-30T11:54:30Z

[Term]
id: GO:1904780
name: negative regulation of protein localization to centrosome
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to centrosome." [GO_REF:0000058, GOC:TermGenie, PMID:17115027]
comment: An example is cdk-2 in C. elegans (UniProt ID O61847) in PMID:17115027 (inferred from mutant phenotype).
synonym: "down regulation of protein localisation to centrosome" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to centrosome" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation to centrosome" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to centrosome" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation to centrosome" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to centrosome" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localisation to centrosome" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to centrosome" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation to centrosome" EXACT [GOC:TermGenie]
is_a: GO:1903828 ! negative regulation of cellular protein localization
is_a: GO:1904779 ! regulation of protein localization to centrosome
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071539 ! protein localization to centrosome
relationship: negatively_regulates GO:0071539 ! protein localization to centrosome
created_by: es
creation_date: 2015-10-30T11:54:47Z

[Term]
id: GO:1904781
name: positive regulation of protein localization to centrosome
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to centrosome." [GO_REF:0000058, GOC:TermGenie, PMID:17115027]
comment: An example is cdk-2 in C. elegans (UniProt ID O61847) in PMID:17115027 (inferred from mutant phenotype).
synonym: "activation of protein localisation to centrosome" NARROW [GOC:TermGenie]
synonym: "activation of protein localization to centrosome" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein localisation to centrosome" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation to centrosome" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to centrosome" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation to centrosome" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to centrosome" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation to centrosome" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to centrosome" EXACT [GOC:TermGenie]
is_a: GO:1903829 ! positive regulation of cellular protein localization
is_a: GO:1904779 ! regulation of protein localization to centrosome
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071539 ! protein localization to centrosome
relationship: positively_regulates GO:0071539 ! protein localization to centrosome
created_by: es
creation_date: 2015-10-30T11:54:53Z

[Term]
id: GO:1904782
name: negative regulation of NMDA glutamate receptor activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of NMDA glutamate receptor activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:12857]
synonym: "down regulation of N-methyl-D-aspartate selective glutamate receptor activity" EXACT [GOC:TermGenie]
synonym: "down regulation of NMDA glutamate receptor activity" EXACT [GOC:TermGenie]
synonym: "down regulation of NMDA receptor" EXACT [GOC:TermGenie]
synonym: "down-regulation of N-methyl-D-aspartate selective glutamate receptor activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of NMDA glutamate receptor activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of NMDA receptor" EXACT [GOC:TermGenie]
synonym: "downregulation of N-methyl-D-aspartate selective glutamate receptor activity" EXACT [GOC:TermGenie]
synonym: "downregulation of NMDA glutamate receptor activity" EXACT [GOC:TermGenie]
synonym: "downregulation of NMDA receptor" EXACT [GOC:TermGenie]
synonym: "inhibition of N-methyl-D-aspartate selective glutamate receptor activity" NARROW [GOC:TermGenie]
synonym: "inhibition of NMDA glutamate receptor activity" NARROW [GOC:TermGenie]
synonym: "inhibition of NMDA receptor" NARROW [GOC:TermGenie]
synonym: "negative regulation of N-methyl-D-aspartate selective glutamate receptor activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of NMDA receptor" EXACT [GOC:TermGenie]
is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity
is_a: GO:0050805 ! negative regulation of synaptic transmission
is_a: GO:1900450 ! negative regulation of glutamate receptor signaling pathway
is_a: GO:2000272 ! negative regulation of receptor activity
is_a: GO:2000310 ! regulation of N-methyl-D-aspartate selective glutamate receptor activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004972 ! NMDA glutamate receptor activity
relationship: negatively_regulates GO:0004972 ! NMDA glutamate receptor activity
created_by: mr
creation_date: 2015-10-30T19:39:31Z

[Term]
id: GO:1904783
name: positive regulation of NMDA glutamate receptor activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of NMDA glutamate receptor activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:12857]
synonym: "activation of N-methyl-D-aspartate selective glutamate receptor activity" NARROW [GOC:TermGenie]
synonym: "activation of NMDA glutamate receptor activity" NARROW [GOC:TermGenie]
synonym: "activation of NMDA receptor" NARROW [GOC:TermGenie]
synonym: "positive regulation of N-methyl-D-aspartate selective glutamate receptor activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of NMDA receptor" EXACT [GOC:TermGenie]
synonym: "up regulation of N-methyl-D-aspartate selective glutamate receptor activity" EXACT [GOC:TermGenie]
synonym: "up regulation of NMDA glutamate receptor activity" EXACT [GOC:TermGenie]
synonym: "up regulation of NMDA receptor" EXACT [GOC:TermGenie]
synonym: "up-regulation of N-methyl-D-aspartate selective glutamate receptor activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of NMDA glutamate receptor activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of NMDA receptor" EXACT [GOC:TermGenie]
synonym: "upregulation of N-methyl-D-aspartate selective glutamate receptor activity" EXACT [GOC:TermGenie]
synonym: "upregulation of NMDA glutamate receptor activity" EXACT [GOC:TermGenie]
synonym: "upregulation of NMDA receptor" EXACT [GOC:TermGenie]
is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity
is_a: GO:0050806 ! positive regulation of synaptic transmission
is_a: GO:1900451 ! positive regulation of glutamate receptor signaling pathway
is_a: GO:2000273 ! positive regulation of receptor activity
is_a: GO:2000310 ! regulation of N-methyl-D-aspartate selective glutamate receptor activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004972 ! NMDA glutamate receptor activity
relationship: positively_regulates GO:0004972 ! NMDA glutamate receptor activity
created_by: mr
creation_date: 2015-10-30T19:39:37Z

[Term]
id: GO:1904784
name: NLRP1 inflammasome complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a NLRP1 inflammasome complex." [GO_REF:0000079, GOC:TermGenie, PMID:19124602]
comment: The aggregation, arrangement and bonding together of a set of components to form the NLRP1 inflammasome complex, occurring at the level of an individual cell.
synonym: "NALP1 inflammasome complex assembly" EXACT [GOC:TermGenie]
synonym: "NALP1 inflammasome complex formation" EXACT [GOC:TermGenie]
synonym: "NLRP1 inflammasome complex formation" EXACT [GOC:TermGenie]
is_a: GO:0006461 ! protein complex assembly
created_by: ae
creation_date: 2015-11-02T09:39:44Z

[Term]
id: GO:1904785
name: regulation of asymmetric protein localization involved in cell fate determination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of asymmetric protein localization involved in cell fate determination." [GO_REF:0000058, GOC:TermGenie, PMID:17476329]
comment: wrm-1 in C. Elegans (Q10953) in PMID:17476329 (IMP)
synonym: "regulation of asymmetric protein localisation involved in cell fate determination" EXACT [GOC:TermGenie]
synonym: "regulation of asymmetric protein localization involved in cell fate commitment" EXACT [GOC:TermGenie]
synonym: "regulation of asymmetric protein localization resulting in cell fate commitment" EXACT [GOC:TermGenie]
synonym: "regulation of cell fate commitment, asymmetric protein localization" EXACT [GOC:TermGenie]
is_a: GO:0010453 ! regulation of cell fate commitment
is_a: GO:0032880 ! regulation of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045167 ! asymmetric protein localization involved in cell fate determination
relationship: regulates GO:0045167 ! asymmetric protein localization involved in cell fate determination
created_by: es
creation_date: 2015-11-03T12:11:06Z

[Term]
id: GO:1904786
name: negative regulation of asymmetric protein localization involved in cell fate determination
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of asymmetric protein localization involved in cell fate determination." [GO_REF:0000058, GOC:TermGenie, PMID:17476329]
comment: wrm-1 in C. Elegans (Q10953) in PMID:17476329 (IMP)
synonym: "down regulation of asymmetric protein localisation involved in cell fate determination" EXACT [GOC:TermGenie]
synonym: "down regulation of asymmetric protein localization involved in cell fate commitment" EXACT [GOC:TermGenie]
synonym: "down regulation of asymmetric protein localization involved in cell fate determination" EXACT [GOC:TermGenie]
synonym: "down regulation of asymmetric protein localization resulting in cell fate commitment" EXACT [GOC:TermGenie]
synonym: "down regulation of cell fate commitment, asymmetric protein localization" EXACT [GOC:TermGenie]
synonym: "down-regulation of asymmetric protein localisation involved in cell fate determination" EXACT [GOC:TermGenie]
synonym: "down-regulation of asymmetric protein localization involved in cell fate commitment" EXACT [GOC:TermGenie]
synonym: "down-regulation of asymmetric protein localization involved in cell fate determination" EXACT [GOC:TermGenie]
synonym: "down-regulation of asymmetric protein localization resulting in cell fate commitment" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell fate commitment, asymmetric protein localization" EXACT [GOC:TermGenie]
synonym: "downregulation of asymmetric protein localisation involved in cell fate determination" EXACT [GOC:TermGenie]
synonym: "downregulation of asymmetric protein localization involved in cell fate commitment" EXACT [GOC:TermGenie]
synonym: "downregulation of asymmetric protein localization involved in cell fate determination" EXACT [GOC:TermGenie]
synonym: "downregulation of asymmetric protein localization resulting in cell fate commitment" EXACT [GOC:TermGenie]
synonym: "downregulation of cell fate commitment, asymmetric protein localization" EXACT [GOC:TermGenie]
synonym: "inhibition of asymmetric protein localisation involved in cell fate determination" NARROW [GOC:TermGenie]
synonym: "inhibition of asymmetric protein localization involved in cell fate commitment" NARROW [GOC:TermGenie]
synonym: "inhibition of asymmetric protein localization involved in cell fate determination" NARROW [GOC:TermGenie]
synonym: "inhibition of asymmetric protein localization resulting in cell fate commitment" NARROW [GOC:TermGenie]
synonym: "inhibition of cell fate commitment, asymmetric protein localization" NARROW [GOC:TermGenie]
synonym: "negative regulation of asymmetric protein localisation involved in cell fate determination" EXACT [GOC:TermGenie]
synonym: "negative regulation of asymmetric protein localization involved in cell fate commitment" EXACT [GOC:TermGenie]
synonym: "negative regulation of asymmetric protein localization resulting in cell fate commitment" EXACT [GOC:TermGenie]
synonym: "negative regulation of cell fate commitment, asymmetric protein localization" EXACT [GOC:TermGenie]
is_a: GO:0010454 ! negative regulation of cell fate commitment
is_a: GO:1904785 ! regulation of asymmetric protein localization involved in cell fate determination
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045167 ! asymmetric protein localization involved in cell fate determination
relationship: negatively_regulates GO:0045167 ! asymmetric protein localization involved in cell fate determination
created_by: es
creation_date: 2015-11-03T12:11:13Z

[Term]
id: GO:1904787
name: positive regulation of asymmetric protein localization involved in cell fate determination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of asymmetric protein localization involved in cell fate determination." [GO_REF:0000058, GOC:TermGenie, PMID:17476329]
comment: wrm-1 in C. Elegans (Q10953) in PMID:17476329 (IMP)
synonym: "activation of asymmetric protein localisation involved in cell fate determination" NARROW [GOC:TermGenie]
synonym: "activation of asymmetric protein localization involved in cell fate commitment" NARROW [GOC:TermGenie]
synonym: "activation of asymmetric protein localization involved in cell fate determination" NARROW [GOC:TermGenie]
synonym: "activation of asymmetric protein localization resulting in cell fate commitment" NARROW [GOC:TermGenie]
synonym: "activation of cell fate commitment, asymmetric protein localization" NARROW [GOC:TermGenie]
synonym: "positive regulation of asymmetric protein localisation involved in cell fate determination" EXACT [GOC:TermGenie]
synonym: "positive regulation of asymmetric protein localization involved in cell fate commitment" EXACT [GOC:TermGenie]
synonym: "positive regulation of asymmetric protein localization resulting in cell fate commitment" EXACT [GOC:TermGenie]
synonym: "positive regulation of cell fate commitment, asymmetric protein localization" EXACT [GOC:TermGenie]
synonym: "up regulation of asymmetric protein localisation involved in cell fate determination" EXACT [GOC:TermGenie]
synonym: "up regulation of asymmetric protein localization involved in cell fate commitment" EXACT [GOC:TermGenie]
synonym: "up regulation of asymmetric protein localization involved in cell fate determination" EXACT [GOC:TermGenie]
synonym: "up regulation of asymmetric protein localization resulting in cell fate commitment" EXACT [GOC:TermGenie]
synonym: "up regulation of cell fate commitment, asymmetric protein localization" EXACT [GOC:TermGenie]
synonym: "up-regulation of asymmetric protein localisation involved in cell fate determination" EXACT [GOC:TermGenie]
synonym: "up-regulation of asymmetric protein localization involved in cell fate commitment" EXACT [GOC:TermGenie]
synonym: "up-regulation of asymmetric protein localization involved in cell fate determination" EXACT [GOC:TermGenie]
synonym: "up-regulation of asymmetric protein localization resulting in cell fate commitment" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell fate commitment, asymmetric protein localization" EXACT [GOC:TermGenie]
synonym: "upregulation of asymmetric protein localisation involved in cell fate determination" EXACT [GOC:TermGenie]
synonym: "upregulation of asymmetric protein localization involved in cell fate commitment" EXACT [GOC:TermGenie]
synonym: "upregulation of asymmetric protein localization involved in cell fate determination" EXACT [GOC:TermGenie]
synonym: "upregulation of asymmetric protein localization resulting in cell fate commitment" EXACT [GOC:TermGenie]
synonym: "upregulation of cell fate commitment, asymmetric protein localization" EXACT [GOC:TermGenie]
is_a: GO:0010455 ! positive regulation of cell fate commitment
is_a: GO:1904785 ! regulation of asymmetric protein localization involved in cell fate determination
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045167 ! asymmetric protein localization involved in cell fate determination
relationship: positively_regulates GO:0045167 ! asymmetric protein localization involved in cell fate determination
created_by: es
creation_date: 2015-11-03T12:11:19Z

[Term]
id: GO:1904788
name: positive regulation of induction of conjugation with cellular fusion by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A regulation of transcription from RNA polymerase II promoter that results in positive regulation of induction of conjugation with cellular fusion." [GO_REF:0000063, GOC:TermGenie, PMID:22144909]
synonym: "positive regulation of induction of conjugation with cellular fusion by global transcription regulation from Pol II promoter" RELATED [GOC:TermGenie]
synonym: "positive regulation of induction of conjugation with cellular fusion by regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie]
synonym: "positive regulation of induction of conjugation with cellular fusion by regulation of global transcription from Pol II promoter" RELATED [GOC:TermGenie]
synonym: "positive regulation of induction of conjugation with cellular fusion by regulation of transcription from Pol II promoter" EXACT [GOC:TermGenie]
synonym: "positive regulation of induction of conjugation with cellular fusion by regulation of transcription from RNA polymerase II promoter, global" RELATED [GOC:TermGenie]
is_a: GO:1900237 ! positive regulation of induction of conjugation with cellular fusion
is_a: GO:1900406 ! regulation of conjugation with cellular fusion by regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
intersection_of: positively_regulates GO:0010514 ! induction of conjugation with cellular fusion
relationship: positively_regulates GO:0010514 ! induction of conjugation with cellular fusion
created_by: tb
creation_date: 2015-11-04T21:17:08Z

[Term]
id: GO:1904789
name: regulation of mitotic actomyosin contractile ring maintenance
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitotic actomyosin contractile ring maintenance." [GO_REF:0000058, GOC:TermGenie, PMID:24115772]
synonym: "regulation of contractile ring maintenance involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "regulation of cytokinesis, contractile ring maintenance, involved in cytokinesis during cell cycle involved in mitotic cell cycle" EXACT [GOC:TermGenie]
is_a: GO:0051128 ! regulation of cellular component organization
is_a: GO:1903436 ! regulation of mitotic cytokinetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1902406 ! mitotic actomyosin contractile ring maintenance
relationship: regulates GO:1902406 ! mitotic actomyosin contractile ring maintenance
created_by: mah
creation_date: 2015-11-06T15:42:49Z

[Term]
id: GO:1904790
name: regulation of telosome assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of telosome assembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24270157]
synonym: "regulation of Pot1 complex assembly" EXACT [GOC:TermGenie]
synonym: "regulation of Pot1-Tpz1 complex assembly" EXACT [GOC:TermGenie]
synonym: "regulation of shelterin complex formation" EXACT [GOC:TermGenie]
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071573 ! telosome assembly
relationship: regulates GO:0071573 ! telosome assembly
created_by: nc
creation_date: 2015-11-06T16:13:03Z

[Term]
id: GO:1904791
name: negative regulation of telosome assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of telosome assembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24270157]
synonym: "down regulation of Pot1 complex assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of Pot1-Tpz1 complex assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of shelterin complex formation" EXACT [GOC:TermGenie]
synonym: "down regulation of telosome assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of Pot1 complex assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of Pot1-Tpz1 complex assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of shelterin complex formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of telosome assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of Pot1 complex assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of Pot1-Tpz1 complex assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of shelterin complex formation" EXACT [GOC:TermGenie]
synonym: "downregulation of telosome assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of Pot1 complex assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of Pot1-Tpz1 complex assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of shelterin complex formation" NARROW [GOC:TermGenie]
synonym: "inhibition of telosome assembly" NARROW [GOC:TermGenie]
synonym: "negative regulation of Pot1 complex assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of Pot1-Tpz1 complex assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of shelterin complex formation" EXACT [GOC:TermGenie]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1904790 ! regulation of telosome assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071573 ! telosome assembly
relationship: negatively_regulates GO:0071573 ! telosome assembly
created_by: nc
creation_date: 2015-11-06T16:13:11Z

[Term]
id: GO:1904792
name: positive regulation of telosome assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of telosome assembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24270157]
synonym: "activation of Pot1 complex assembly" NARROW [GOC:TermGenie]
synonym: "activation of Pot1-Tpz1 complex assembly" NARROW [GOC:TermGenie]
synonym: "activation of shelterin complex formation" NARROW [GOC:TermGenie]
synonym: "activation of telosome assembly" NARROW [GOC:TermGenie]
synonym: "positive regulation of Pot1 complex assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of Pot1-Tpz1 complex assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of shelterin complex formation" EXACT [GOC:TermGenie]
synonym: "up regulation of Pot1 complex assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of Pot1-Tpz1 complex assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of shelterin complex formation" EXACT [GOC:TermGenie]
synonym: "up regulation of telosome assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of Pot1 complex assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of Pot1-Tpz1 complex assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of shelterin complex formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of telosome assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of Pot1 complex assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of Pot1-Tpz1 complex assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of shelterin complex formation" EXACT [GOC:TermGenie]
synonym: "upregulation of telosome assembly" EXACT [GOC:TermGenie]
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1904790 ! regulation of telosome assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071573 ! telosome assembly
relationship: positively_regulates GO:0071573 ! telosome assembly
created_by: nc
creation_date: 2015-11-06T16:13:18Z

[Term]
id: GO:1904793
name: regulation of euchromatin binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of euchromatin binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22723415]
is_a: GO:0035561 ! regulation of chromatin binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990188 ! euchromatin binding
relationship: regulates GO:1990188 ! euchromatin binding
created_by: nc
creation_date: 2015-11-09T11:43:04Z

[Term]
id: GO:1904794
name: negative regulation of euchromatin binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of euchromatin binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22723415]
synonym: "down regulation of euchromatin binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of euchromatin binding" EXACT [GOC:TermGenie]
synonym: "downregulation of euchromatin binding" EXACT [GOC:TermGenie]
synonym: "inhibition of euchromatin binding" NARROW [GOC:TermGenie]
is_a: GO:0035562 ! negative regulation of chromatin binding
is_a: GO:1904793 ! regulation of euchromatin binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990188 ! euchromatin binding
relationship: negatively_regulates GO:1990188 ! euchromatin binding
created_by: nc
creation_date: 2015-11-09T11:43:12Z

[Term]
id: GO:1904795
name: positive regulation of euchromatin binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of euchromatin binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22723415]
synonym: "activation of euchromatin binding" NARROW [GOC:TermGenie]
synonym: "up regulation of euchromatin binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of euchromatin binding" EXACT [GOC:TermGenie]
synonym: "upregulation of euchromatin binding" EXACT [GOC:TermGenie]
is_a: GO:0035563 ! positive regulation of chromatin binding
is_a: GO:1904793 ! regulation of euchromatin binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990188 ! euchromatin binding
relationship: positively_regulates GO:1990188 ! euchromatin binding
created_by: nc
creation_date: 2015-11-09T11:43:19Z

[Term]
id: GO:1904796
name: regulation of core promoter binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of core promoter binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22723415]
is_a: GO:2000677 ! regulation of transcription regulatory region DNA binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001047 ! core promoter binding
relationship: regulates GO:0001047 ! core promoter binding
created_by: nc
creation_date: 2015-11-09T12:32:23Z

[Term]
id: GO:1904797
name: negative regulation of core promoter binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of core promoter binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22723415]
synonym: "down regulation of core promoter binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of core promoter binding" EXACT [GOC:TermGenie]
synonym: "downregulation of core promoter binding" EXACT [GOC:TermGenie]
synonym: "inhibition of core promoter binding" NARROW [GOC:TermGenie]
is_a: GO:1904796 ! regulation of core promoter binding
is_a: GO:2000678 ! negative regulation of transcription regulatory region DNA binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001047 ! core promoter binding
relationship: negatively_regulates GO:0001047 ! core promoter binding
created_by: nc
creation_date: 2015-11-09T12:32:31Z

[Term]
id: GO:1904798
name: positive regulation of core promoter binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of core promoter binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22723415]
synonym: "activation of core promoter binding" NARROW [GOC:TermGenie]
synonym: "up regulation of core promoter binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of core promoter binding" EXACT [GOC:TermGenie]
synonym: "upregulation of core promoter binding" EXACT [GOC:TermGenie]
is_a: GO:1904796 ! regulation of core promoter binding
is_a: GO:2000679 ! positive regulation of transcription regulatory region DNA binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001047 ! core promoter binding
relationship: positively_regulates GO:0001047 ! core promoter binding
created_by: nc
creation_date: 2015-11-09T12:32:38Z

[Term]
id: GO:1904799
name: regulation of neuron remodeling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neuron remodeling." [GO_REF:0000058, GOC:TermGenie, PMID:21609829]
comment: cyy-1 in C. Elegans (P34624) in PMID:21609829 (inferred from mutant phenotype)
synonym: "regulation of axon pruning" NARROW [GOC:TermGenie]
synonym: "regulation of neuronal remodeling" EXACT [GOC:TermGenie]
is_a: GO:0014041 ! regulation of neuron maturation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016322 ! neuron remodeling
relationship: regulates GO:0016322 ! neuron remodeling
created_by: es
creation_date: 2015-11-09T13:46:52Z

[Term]
id: GO:1904800
name: negative regulation of neuron remodeling
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuron remodeling." [GO_REF:0000058, GOC:TermGenie, PMID:21609829]
comment: cyy-1 in C. Elegans (P34624) in PMID:21609829 (inferred from mutant phenotype)
synonym: "down regulation of axon pruning" NARROW [GOC:TermGenie]
synonym: "down regulation of neuron remodeling" EXACT [GOC:TermGenie]
synonym: "down regulation of neuronal remodeling" EXACT [GOC:TermGenie]
synonym: "down-regulation of axon pruning" NARROW [GOC:TermGenie]
synonym: "down-regulation of neuron remodeling" EXACT [GOC:TermGenie]
synonym: "down-regulation of neuronal remodeling" EXACT [GOC:TermGenie]
synonym: "downregulation of axon pruning" NARROW [GOC:TermGenie]
synonym: "downregulation of neuron remodeling" EXACT [GOC:TermGenie]
synonym: "downregulation of neuronal remodeling" EXACT [GOC:TermGenie]
synonym: "inhibition of axon pruning" NARROW [GOC:TermGenie]
synonym: "inhibition of neuron remodeling" NARROW [GOC:TermGenie]
synonym: "inhibition of neuronal remodeling" NARROW [GOC:TermGenie]
synonym: "negative regulation of axon pruning" NARROW [GOC:TermGenie]
synonym: "negative regulation of neuronal remodeling" EXACT [GOC:TermGenie]
is_a: GO:0014043 ! negative regulation of neuron maturation
is_a: GO:1904799 ! regulation of neuron remodeling
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016322 ! neuron remodeling
relationship: negatively_regulates GO:0016322 ! neuron remodeling
created_by: es
creation_date: 2015-11-09T13:47:00Z

[Term]
id: GO:1904801
name: positive regulation of neuron remodeling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neuron remodeling." [GO_REF:0000058, GOC:TermGenie, PMID:21609829]
comment: cyy-1 in C. Elegans (P34624) in PMID:21609829 (inferred from mutant phenotype)
synonym: "activation of axon pruning" NARROW [GOC:TermGenie]
synonym: "activation of neuron remodeling" NARROW [GOC:TermGenie]
synonym: "activation of neuronal remodeling" NARROW [GOC:TermGenie]
synonym: "positive regulation of axon pruning" NARROW [GOC:TermGenie]
synonym: "positive regulation of neuronal remodeling" EXACT [GOC:TermGenie]
synonym: "up regulation of axon pruning" NARROW [GOC:TermGenie]
synonym: "up regulation of neuron remodeling" EXACT [GOC:TermGenie]
synonym: "up regulation of neuronal remodeling" EXACT [GOC:TermGenie]
synonym: "up-regulation of axon pruning" NARROW [GOC:TermGenie]
synonym: "up-regulation of neuron remodeling" EXACT [GOC:TermGenie]
synonym: "up-regulation of neuronal remodeling" EXACT [GOC:TermGenie]
synonym: "upregulation of axon pruning" NARROW [GOC:TermGenie]
synonym: "upregulation of neuron remodeling" EXACT [GOC:TermGenie]
synonym: "upregulation of neuronal remodeling" EXACT [GOC:TermGenie]
is_a: GO:0014042 ! positive regulation of neuron maturation
is_a: GO:1904799 ! regulation of neuron remodeling
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016322 ! neuron remodeling
relationship: positively_regulates GO:0016322 ! neuron remodeling
created_by: es
creation_date: 2015-11-09T13:47:07Z

[Term]
id: GO:1904802
name: RITS complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a RITS complex." [GO_REF:0000079, GOC:TermGenie, PMID:26443059]
synonym: "RITS complex formation" EXACT [GOC:TermGenie]
is_a: GO:0022618 ! ribonucleoprotein complex assembly
created_by: mah
creation_date: 2015-11-09T16:17:54Z

[Term]
id: GO:1904803
name: regulation of translation involved in cellular response to UV
namespace: biological_process
def: "Any regulation of translation that is involved in cellular response to UV." [GO_REF:0000060, GOC:TermGenie, PMID:17369398]
synonym: "regulation of protein anabolism involved in cellular response to UV" EXACT [GOC:TermGenie]
synonym: "regulation of protein biosynthesis involved in cellular response to UV" EXACT [GOC:TermGenie]
synonym: "regulation of protein formation involved in cellular response to UV" EXACT [GOC:TermGenie]
synonym: "regulation of protein synthesis involved in cellular response to UV" EXACT [GOC:TermGenie]
synonym: "regulation of translation involved in cellular response to ultraviolet light stimulus" EXACT [GOC:TermGenie]
synonym: "regulation of translation involved in cellular response to ultraviolet radiation stimulus" EXACT [GOC:TermGenie]
synonym: "regulation of translation involved in cellular response to UV light stimulus" EXACT [GOC:TermGenie]
synonym: "regulation of translation involved in cellular response to UV radiation stimulus" EXACT [GOC:TermGenie]
is_a: GO:0006417 ! regulation of translation
intersection_of: GO:0006417 ! regulation of translation
intersection_of: part_of GO:0034644 ! cellular response to UV
relationship: part_of GO:0034644 ! cellular response to UV
created_by: mah
creation_date: 2015-11-10T12:12:41Z

[Term]
id: GO:1904804
name: response to latrunculin A
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a latrunculin A stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:15537703]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0097305 ! response to alcohol
created_by: mah
creation_date: 2015-11-10T14:00:38Z

[Term]
id: GO:1904805
name: cellular response to latrunculin A
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a latrunculin A stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:15537703]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:0097306 ! cellular response to alcohol
is_a: GO:1904804 ! response to latrunculin A
created_by: mah
creation_date: 2015-11-10T14:00:46Z

[Term]
id: GO:1904806
name: regulation of protein oxidation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein oxidation." [GO_REF:0000058, GOC:TermGenie, PMID:22719267]
synonym: "regulation of protein amino acid oxidation" EXACT [GOC:TermGenie]
is_a: GO:0031399 ! regulation of protein modification process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0018158 ! protein oxidation
relationship: regulates GO:0018158 ! protein oxidation
created_by: mec
creation_date: 2015-11-10T14:06:00Z

[Term]
id: GO:1904807
name: negative regulation of protein oxidation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein oxidation." [GO_REF:0000058, GOC:TermGenie, PMID:22719267]
synonym: "down regulation of protein amino acid oxidation" EXACT [GOC:TermGenie]
synonym: "down regulation of protein oxidation" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein amino acid oxidation" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein oxidation" EXACT [GOC:TermGenie]
synonym: "downregulation of protein amino acid oxidation" EXACT [GOC:TermGenie]
synonym: "downregulation of protein oxidation" EXACT [GOC:TermGenie]
synonym: "inhibition of protein amino acid oxidation" NARROW [GOC:TermGenie]
synonym: "inhibition of protein oxidation" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein amino acid oxidation" EXACT [GOC:TermGenie]
is_a: GO:0031400 ! negative regulation of protein modification process
is_a: GO:1904806 ! regulation of protein oxidation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0018158 ! protein oxidation
relationship: negatively_regulates GO:0018158 ! protein oxidation
created_by: mec
creation_date: 2015-11-10T14:06:08Z

[Term]
id: GO:1904808
name: positive regulation of protein oxidation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein oxidation." [GO_REF:0000058, GOC:TermGenie, PMID:22719267]
synonym: "activation of protein amino acid oxidation" NARROW [GOC:TermGenie]
synonym: "activation of protein oxidation" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein amino acid oxidation" EXACT [GOC:TermGenie]
synonym: "up regulation of protein amino acid oxidation" EXACT [GOC:TermGenie]
synonym: "up regulation of protein oxidation" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein amino acid oxidation" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein oxidation" EXACT [GOC:TermGenie]
synonym: "upregulation of protein amino acid oxidation" EXACT [GOC:TermGenie]
synonym: "upregulation of protein oxidation" EXACT [GOC:TermGenie]
is_a: GO:0031401 ! positive regulation of protein modification process
is_a: GO:1904806 ! regulation of protein oxidation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0018158 ! protein oxidation
relationship: positively_regulates GO:0018158 ! protein oxidation
created_by: mec
creation_date: 2015-11-10T14:06:15Z

[Term]
id: GO:1904809
name: regulation of dense core granule transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dense core granule transport." [GO_REF:0000058, GOC:TermGenie, PMID:22699897]
comment: cdk-5 in C.elegans (G5ECH7) in PMID:22699897 (inferred from mutant phenotype).
synonym: "regulation of dense core vesicle transport" EXACT [GOC:TermGenie]
is_a: GO:1903649 ! regulation of cytoplasmic transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1901950 ! dense core granule transport
relationship: regulates GO:1901950 ! dense core granule transport
created_by: es
creation_date: 2015-11-11T10:40:10Z

[Term]
id: GO:1904810
name: negative regulation of dense core granule transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of dense core granule transport." [GO_REF:0000058, GOC:TermGenie, PMID:22699897]
comment: cdk-5 in C.elegans (G5ECH7) in PMID:22699897 (inferred from mutant phenotype).
synonym: "down regulation of dense core granule transport" EXACT [GOC:TermGenie]
synonym: "down regulation of dense core vesicle transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of dense core granule transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of dense core vesicle transport" EXACT [GOC:TermGenie]
synonym: "downregulation of dense core granule transport" EXACT [GOC:TermGenie]
synonym: "downregulation of dense core vesicle transport" EXACT [GOC:TermGenie]
synonym: "inhibition of dense core granule transport" NARROW [GOC:TermGenie]
synonym: "inhibition of dense core vesicle transport" NARROW [GOC:TermGenie]
synonym: "negative regulation of dense core vesicle transport" EXACT [GOC:TermGenie]
is_a: GO:1903650 ! negative regulation of cytoplasmic transport
is_a: GO:1904809 ! regulation of dense core granule transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1901950 ! dense core granule transport
relationship: negatively_regulates GO:1901950 ! dense core granule transport
created_by: es
creation_date: 2015-11-11T10:40:18Z

[Term]
id: GO:1904811
name: positive regulation of dense core granule transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of dense core granule transport." [GO_REF:0000058, GOC:TermGenie, PMID:22699897]
comment: cdk-5 in C.elegans (G5ECH7) in PMID:22699897 (inferred from mutant phenotype).
synonym: "activation of dense core granule transport" NARROW [GOC:TermGenie]
synonym: "activation of dense core vesicle transport" NARROW [GOC:TermGenie]
synonym: "positive regulation of dense core vesicle transport" EXACT [GOC:TermGenie]
synonym: "up regulation of dense core granule transport" EXACT [GOC:TermGenie]
synonym: "up regulation of dense core vesicle transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of dense core granule transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of dense core vesicle transport" EXACT [GOC:TermGenie]
synonym: "upregulation of dense core granule transport" EXACT [GOC:TermGenie]
synonym: "upregulation of dense core vesicle transport" EXACT [GOC:TermGenie]
is_a: GO:1903651 ! positive regulation of cytoplasmic transport
is_a: GO:1904809 ! regulation of dense core granule transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1901950 ! dense core granule transport
relationship: positively_regulates GO:1901950 ! dense core granule transport
created_by: es
creation_date: 2015-11-11T10:40:25Z

[Term]
id: GO:1904812
name: rRNA acetylation involved in maturation of SSU-rRNA
namespace: biological_process
def: "Any rRNA acetylation that is involved in maturation of SSU-rRNA." [GO_REF:0000060, GOC:TermGenie, PMID:25402480]
synonym: "rRNA acetylation involved in processing of 20S pre-rRNA" NARROW [GOC:TermGenie]
synonym: "rRNA acetylation involved in SSU-rRNA maturation" EXACT [GOC:TermGenie]
is_a: GO:1990882 ! rRNA acetylation
intersection_of: GO:1990882 ! rRNA acetylation
intersection_of: part_of GO:0030490 ! maturation of SSU-rRNA
relationship: part_of GO:0030490 ! maturation of SSU-rRNA
created_by: al
creation_date: 2015-11-11T15:38:41Z

[Term]
id: GO:1904813
name: ficolin-1-rich granule lumen
namespace: cellular_component
def: "Any membrane-enclosed lumen that is part of a ficolin-1-rich granule." [GO_REF:0000064, GOC:TermGenie, PMID:23650620]
synonym: "ficolin-1-rich granule membrane-enclosed lumen" EXACT []
synonym: "membrane-enclosed lumen of ficolin granule" RELATED [GOC:TermGenie]
synonym: "membrane-enclosed lumen of ficolin-1 rich granule" EXACT [GOC:TermGenie]
synonym: "membrane-enclosed lumen of ficolin-1-rich granule" EXACT [GOC:TermGenie]
is_a: GO:0031974 ! membrane-enclosed lumen
is_a: GO:0044433 ! cytoplasmic vesicle part
intersection_of: GO:0031974 ! membrane-enclosed lumen
intersection_of: part_of GO:0101002 ! ficolin-1-rich granule
relationship: part_of GO:0101002 ! ficolin-1-rich granule
created_by: mec
creation_date: 2015-11-13T11:58:20Z

[Term]
id: GO:1904814
name: regulation of protein localization to chromosome, telomeric region
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to chromosome, telomeric region." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:19487455]
synonym: "regulation of protein localisation to chromosome, telomeric region" EXACT [GOC:TermGenie]
synonym: "regulation of protein localization to telomere" EXACT [GOC:TermGenie]
is_a: GO:1903827 ! regulation of cellular protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070198 ! protein localization to chromosome, telomeric region
relationship: regulates GO:0070198 ! protein localization to chromosome, telomeric region
created_by: nc
creation_date: 2015-11-16T12:18:43Z

[Term]
id: GO:1904815
name: negative regulation of protein localization to chromosome, telomeric region
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to chromosome, telomeric region." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:19487455]
synonym: "down regulation of protein localisation to chromosome, telomeric region" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to telomere" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation to chromosome, telomeric region" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to telomere" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation to chromosome, telomeric region" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to telomere" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localisation to chromosome, telomeric region" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to chromosome, telomeric region" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to telomere" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation to chromosome, telomeric region" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localization to telomere" EXACT [GOC:TermGenie]
is_a: GO:1903828 ! negative regulation of cellular protein localization
is_a: GO:1904814 ! regulation of protein localization to chromosome, telomeric region
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070198 ! protein localization to chromosome, telomeric region
relationship: negatively_regulates GO:0070198 ! protein localization to chromosome, telomeric region
created_by: nc
creation_date: 2015-11-16T12:18:51Z

[Term]
id: GO:1904816
name: positive regulation of protein localization to chromosome, telomeric region
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to chromosome, telomeric region." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:19487455]
synonym: "activation of protein localisation to chromosome, telomeric region" NARROW [GOC:TermGenie]
synonym: "activation of protein localization to chromosome, telomeric region" NARROW [GOC:TermGenie]
synonym: "activation of protein localization to telomere" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein localisation to chromosome, telomeric region" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localization to telomere" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation to chromosome, telomeric region" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to telomere" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation to chromosome, telomeric region" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to telomere" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation to chromosome, telomeric region" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to telomere" EXACT [GOC:TermGenie]
is_a: GO:1903829 ! positive regulation of cellular protein localization
is_a: GO:1904814 ! regulation of protein localization to chromosome, telomeric region
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070198 ! protein localization to chromosome, telomeric region
relationship: positively_regulates GO:0070198 ! protein localization to chromosome, telomeric region
created_by: nc
creation_date: 2015-11-16T12:18:58Z

[Term]
id: GO:1904817
name: serous membrane development
namespace: biological_process
def: "The process whose specific outcome is the progression of a serous membrane over time, from its formation to the mature structure." [GO_REF:0000094, GOC:dph, GOC:TermGenie, PMID:15840053]
synonym: "serosa development" RELATED [GOC:TermGenie]
synonym: "tunica serosa development" EXACT [GOC:TermGenie]
synonym: "wall of serous sac development" EXACT [GOC:TermGenie]
is_a: GO:0048856 ! anatomical structure development
created_by: dph
creation_date: 2015-11-17T19:00:01Z

[Term]
id: GO:1904818
name: visceral peritoneum development
namespace: biological_process
def: "The process whose specific outcome is the progression of a visceral peritoneum over time, from its formation to the mature structure." [GO_REF:0000094, GOC:dph, GOC:TermGenie, PMID:15840053]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:1904820 ! peritoneum development
created_by: dph
creation_date: 2015-11-17T19:00:17Z

[Term]
id: GO:1904819
name: parietal peritoneum development
namespace: biological_process
def: "The process whose specific outcome is the progression of a parietal peritoneum over time, from its formation to the mature structure." [GO_REF:0000094, GOC:dph, GOC:TermGenie, PMID:15840053]
synonym: "peritoneal cavity lining development" EXACT [GOC:TermGenie]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:1904820 ! peritoneum development
created_by: dph
creation_date: 2015-11-17T19:00:24Z

[Term]
id: GO:1904820
name: peritoneum development
namespace: biological_process
def: "The process whose specific outcome is the progression of a peritoneum over time, from its formation to the mature structure." [GO_REF:0000094, GOC:dph, GOC:TermGenie, PMID:15840053]
synonym: "peritonaeum development" RELATED [GOC:TermGenie]
is_a: GO:1904817 ! serous membrane development
created_by: dph
creation_date: 2015-11-18T17:23:51Z

[Term]
id: GO:1904821
name: chloroplast disassembly
namespace: biological_process
def: "The disaggregation of a chloroplast into its constituent components." [GO_REF:0000079, GOC:TermGenie, PMID:26494759]
comment: The disaggregation of a chloroplast into its constituent components.
synonym: "chloroplast degradation" RELATED [PMID:26494759]
is_a: GO:0009658 ! chloroplast organization
is_a: GO:1903008 ! organelle disassembly
created_by: lr
creation_date: 2015-11-19T00:41:18Z

[Term]
id: GO:1904822
name: ubiquitin protein ligase activity involved in chloroplast disassembly
namespace: molecular_function
def: "Any ubiquitin protein ligase activity that is involved in chloroplast disassembly." [GO_REF:0000061, GOC:TermGenie, PMID:26494759]
comment: Any ubiquitin protein ligase activity that is involved in the chloroplast disassembly pathway
synonym: "E3 involved in chloroplast degradation" RELATED [GOC:TermGenie]
synonym: "E3 involved in chloroplast disassembly" RELATED [GOC:TermGenie]
synonym: "protein ubiquitination activity involved in chloroplast degradation" RELATED [GOC:TermGenie]
synonym: "protein ubiquitination activity involved in chloroplast disassembly" EXACT [GOC:TermGenie]
synonym: "ubiquitin ligase activity involved in chloroplast degradation" RELATED [GOC:TermGenie]
synonym: "ubiquitin ligase activity involved in chloroplast disassembly" EXACT [GOC:TermGenie]
synonym: "ubiquitin protein ligase activity involved in chloroplast degradation" RELATED [GOC:TermGenie]
is_a: GO:0061630 ! ubiquitin protein ligase activity
intersection_of: GO:0061630 ! ubiquitin protein ligase activity
intersection_of: part_of GO:1904821 ! chloroplast disassembly
relationship: part_of GO:1904821 ! chloroplast disassembly
created_by: lr
creation_date: 2015-11-19T00:54:09Z

[Term]
id: GO:1904823
name: purine nucleobase transmembrane transport
namespace: biological_process
def: "The directed movement of purine nucleobase across a membrane." [GO_REF:0000069, GOC:TermGenie]
is_a: GO:0006863 ! purine nucleobase transport
is_a: GO:0072530 ! purine-containing compound transmembrane transport
created_by: vw
creation_date: 2015-11-19T09:07:56Z

[Term]
id: GO:1904824
name: anaphase-promoting complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an anaphase-promoting complex." [GO_REF:0000079, GOC:TermGenie, PMID:16950791]
synonym: "anaphase promoting complex assembly" EXACT [GOC:TermGenie]
synonym: "anaphase promoting complex formation" EXACT [GOC:TermGenie]
synonym: "anaphase-promoting complex formation" EXACT [GOC:TermGenie]
synonym: "APC assembly" BROAD []
synonym: "cyclosome assembly" EXACT [GOC:TermGenie]
synonym: "cyclosome formation" EXACT [GOC:TermGenie]
is_a: GO:0006461 ! protein complex assembly
created_by: mah
creation_date: 2015-11-23T12:28:59Z

[Term]
id: GO:1904825
name: protein localization to microtubule plus-end
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location at a microtubule plus-end." [GO_REF:0000087, GOC:TermGenie, PMID:24039245]
synonym: "protein localisation to microtubule plus-end" EXACT [GOC:TermGenie]
is_a: GO:0035372 ! protein localization to microtubule
created_by: mah
creation_date: 2015-11-23T12:34:09Z

[Term]
id: GO:1904826
name: regulation of hydrogen sulfide biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hydrogen sulfide biosynthetic process." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22034194]
synonym: "regulation of hydrogen sulfide anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of hydrogen sulfide biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of hydrogen sulfide formation" EXACT [GOC:TermGenie]
synonym: "regulation of hydrogen sulfide synthesis" EXACT [GOC:TermGenie]
synonym: "regulation of hydrogen sulphide biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of hydrogen sulphide biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070814 ! hydrogen sulfide biosynthetic process
relationship: regulates GO:0070814 ! hydrogen sulfide biosynthetic process
created_by: rph
creation_date: 2015-11-24T10:15:26Z

[Term]
id: GO:1904827
name: negative regulation of hydrogen sulfide biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen sulfide biosynthetic process." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22034194]
synonym: "down regulation of hydrogen sulfide anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of hydrogen sulfide biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of hydrogen sulfide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of hydrogen sulfide formation" EXACT [GOC:TermGenie]
synonym: "down regulation of hydrogen sulfide synthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of hydrogen sulphide biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of hydrogen sulphide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of hydrogen sulfide anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of hydrogen sulfide biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of hydrogen sulfide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of hydrogen sulfide formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of hydrogen sulfide synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of hydrogen sulphide biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of hydrogen sulphide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of hydrogen sulfide anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of hydrogen sulfide biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of hydrogen sulfide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of hydrogen sulfide formation" EXACT [GOC:TermGenie]
synonym: "downregulation of hydrogen sulfide synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of hydrogen sulphide biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of hydrogen sulphide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "inhibition of hydrogen sulfide anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of hydrogen sulfide biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of hydrogen sulfide biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of hydrogen sulfide formation" NARROW [GOC:TermGenie]
synonym: "inhibition of hydrogen sulfide synthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of hydrogen sulphide biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of hydrogen sulphide biosynthetic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of hydrogen sulfide anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of hydrogen sulfide biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of hydrogen sulfide formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of hydrogen sulfide synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of hydrogen sulphide biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of hydrogen sulphide biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0051175 ! negative regulation of sulfur metabolic process
is_a: GO:1904826 ! regulation of hydrogen sulfide biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070814 ! hydrogen sulfide biosynthetic process
relationship: negatively_regulates GO:0070814 ! hydrogen sulfide biosynthetic process
created_by: rph
creation_date: 2015-11-24T10:15:34Z

[Term]
id: GO:1904828
name: positive regulation of hydrogen sulfide biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hydrogen sulfide biosynthetic process." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22034194]
synonym: "activation of hydrogen sulfide anabolism" NARROW [GOC:TermGenie]
synonym: "activation of hydrogen sulfide biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of hydrogen sulfide biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of hydrogen sulfide formation" NARROW [GOC:TermGenie]
synonym: "activation of hydrogen sulfide synthesis" NARROW [GOC:TermGenie]
synonym: "activation of hydrogen sulphide biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of hydrogen sulphide biosynthetic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of hydrogen sulfide anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of hydrogen sulfide biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of hydrogen sulfide formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of hydrogen sulfide synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of hydrogen sulphide biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of hydrogen sulphide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of hydrogen sulfide anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of hydrogen sulfide biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of hydrogen sulfide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of hydrogen sulfide formation" EXACT [GOC:TermGenie]
synonym: "up regulation of hydrogen sulfide synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of hydrogen sulphide biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of hydrogen sulphide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of hydrogen sulfide anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of hydrogen sulfide biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of hydrogen sulfide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of hydrogen sulfide formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of hydrogen sulfide synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of hydrogen sulphide biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of hydrogen sulphide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of hydrogen sulfide anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of hydrogen sulfide biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of hydrogen sulfide biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of hydrogen sulfide formation" EXACT [GOC:TermGenie]
synonym: "upregulation of hydrogen sulfide synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of hydrogen sulphide biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of hydrogen sulphide biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0051176 ! positive regulation of sulfur metabolic process
is_a: GO:1904826 ! regulation of hydrogen sulfide biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070814 ! hydrogen sulfide biosynthetic process
relationship: positively_regulates GO:0070814 ! hydrogen sulfide biosynthetic process
created_by: rph
creation_date: 2015-11-24T10:15:41Z

[Term]
id: GO:1904829
name: regulation of aortic smooth muscle cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of aortic smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22034194]
is_a: GO:1905063 ! regulation of vascular smooth muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035887 ! aortic smooth muscle cell differentiation
relationship: regulates GO:0035887 ! aortic smooth muscle cell differentiation
created_by: rph
creation_date: 2015-11-24T10:20:40Z

[Term]
id: GO:1904830
name: negative regulation of aortic smooth muscle cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of aortic smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22034194]
synonym: "down regulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of aortic smooth muscle cell differentiation" NARROW [GOC:TermGenie]
is_a: GO:1904829 ! regulation of aortic smooth muscle cell differentiation
is_a: GO:1905064 ! negative regulation of vascular smooth muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035887 ! aortic smooth muscle cell differentiation
relationship: negatively_regulates GO:0035887 ! aortic smooth muscle cell differentiation
created_by: rph
creation_date: 2015-11-24T10:20:47Z

[Term]
id: GO:1904831
name: positive regulation of aortic smooth muscle cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of aortic smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22034194]
synonym: "activation of aortic smooth muscle cell differentiation" NARROW [GOC:TermGenie]
synonym: "up regulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:1904829 ! regulation of aortic smooth muscle cell differentiation
is_a: GO:1905065 ! positive regulation of vascular smooth muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035887 ! aortic smooth muscle cell differentiation
relationship: positively_regulates GO:0035887 ! aortic smooth muscle cell differentiation
created_by: rph
creation_date: 2015-11-24T10:20:54Z

[Term]
id: GO:1904832
name: negative regulation of removal of superoxide radicals
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of removal of superoxide radicals." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22836756]
synonym: "down regulation of cellular detoxification of superoxide radicals" EXACT [GOC:TermGenie]
synonym: "down regulation of removal of O2-" EXACT [GOC:TermGenie]
synonym: "down regulation of removal of oxygen free radicals" EXACT [GOC:TermGenie]
synonym: "down regulation of removal of superoxide radicals" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular detoxification of superoxide radicals" EXACT [GOC:TermGenie]
synonym: "down-regulation of removal of O2-" EXACT [GOC:TermGenie]
synonym: "down-regulation of removal of oxygen free radicals" EXACT [GOC:TermGenie]
synonym: "down-regulation of removal of superoxide radicals" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular detoxification of superoxide radicals" EXACT [GOC:TermGenie]
synonym: "downregulation of removal of O2-" EXACT [GOC:TermGenie]
synonym: "downregulation of removal of oxygen free radicals" EXACT [GOC:TermGenie]
synonym: "downregulation of removal of superoxide radicals" EXACT [GOC:TermGenie]
synonym: "inhibition of cellular detoxification of superoxide radicals" NARROW [GOC:TermGenie]
synonym: "inhibition of removal of O2-" NARROW [GOC:TermGenie]
synonym: "inhibition of removal of oxygen free radicals" NARROW [GOC:TermGenie]
synonym: "inhibition of removal of superoxide radicals" NARROW [GOC:TermGenie]
synonym: "negative regulation of cellular detoxification of superoxide radicals" EXACT [GOC:TermGenie]
synonym: "negative regulation of removal of O2-" EXACT [GOC:TermGenie]
synonym: "negative regulation of removal of oxygen free radicals" EXACT [GOC:TermGenie]
is_a: GO:1900408 ! negative regulation of cellular response to oxidative stress
is_a: GO:1901032 ! negative regulation of response to reactive oxygen species
is_a: GO:2000121 ! regulation of removal of superoxide radicals
is_a: GO:2000378 ! negative regulation of reactive oxygen species metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019430 ! removal of superoxide radicals
relationship: negatively_regulates GO:0019430 ! removal of superoxide radicals
created_by: rph
creation_date: 2015-11-24T15:30:18Z

[Term]
id: GO:1904833
name: positive regulation of removal of superoxide radicals
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of removal of superoxide radicals." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22836756]
synonym: "activation of cellular detoxification of superoxide radicals" NARROW [GOC:TermGenie]
synonym: "activation of removal of O2-" NARROW [GOC:TermGenie]
synonym: "activation of removal of oxygen free radicals" NARROW [GOC:TermGenie]
synonym: "activation of removal of superoxide radicals" NARROW [GOC:TermGenie]
synonym: "positive regulation of cellular detoxification of superoxide radicals" EXACT [GOC:TermGenie]
synonym: "positive regulation of removal of O2-" EXACT [GOC:TermGenie]
synonym: "positive regulation of removal of oxygen free radicals" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular detoxification of superoxide radicals" EXACT [GOC:TermGenie]
synonym: "up regulation of removal of O2-" EXACT [GOC:TermGenie]
synonym: "up regulation of removal of oxygen free radicals" EXACT [GOC:TermGenie]
synonym: "up regulation of removal of superoxide radicals" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular detoxification of superoxide radicals" EXACT [GOC:TermGenie]
synonym: "up-regulation of removal of O2-" EXACT [GOC:TermGenie]
synonym: "up-regulation of removal of oxygen free radicals" EXACT [GOC:TermGenie]
synonym: "up-regulation of removal of superoxide radicals" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular detoxification of superoxide radicals" EXACT [GOC:TermGenie]
synonym: "upregulation of removal of O2-" EXACT [GOC:TermGenie]
synonym: "upregulation of removal of oxygen free radicals" EXACT [GOC:TermGenie]
synonym: "upregulation of removal of superoxide radicals" EXACT [GOC:TermGenie]
is_a: GO:1900409 ! positive regulation of cellular response to oxidative stress
is_a: GO:1901033 ! positive regulation of response to reactive oxygen species
is_a: GO:2000121 ! regulation of removal of superoxide radicals
is_a: GO:2000379 ! positive regulation of reactive oxygen species metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0019430 ! removal of superoxide radicals
relationship: positively_regulates GO:0019430 ! removal of superoxide radicals
created_by: rph
creation_date: 2015-11-24T15:30:26Z

[Term]
id: GO:1904834
name: nuclear CENP-A containing chromatin
namespace: cellular_component
def: "Any CENP-A containing chromatin that is part of nuclear chromatin." [GO_REF:0000064, GOC:TermGenie, PMID:24710126]
synonym: "nuclear centromeric core domain chromatin" RELATED []
synonym: "nuclear centromeric core region chromatin" EXACT []
synonym: "nuclear chromatin containing CENP-A" EXACT []
is_a: GO:0000790 ! nuclear chromatin
is_a: GO:0061638 ! CENP-A containing chromatin
created_by: mah
creation_date: 2015-11-30T12:32:34Z

[Term]
id: GO:1904835
name: dorsal root ganglion morphogenesis
namespace: biological_process
def: "The developmental process by which a dorsal root ganglion is generated and organized." [GO_REF:0000083, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18936100]
synonym: "dorsal root ganglia morphogenesis" RELATED [GOC:TermGenie]
synonym: "DRG morphogenesis" RELATED [GOC:TermGenie]
synonym: "ganglion of dorsal root morphogenesis" EXACT [GOC:TermGenie]
synonym: "ganglion sensorium nervi spinalis morphogenesis" RELATED [GOC:TermGenie]
synonym: "ganglion spinale morphogenesis" RELATED [GOC:TermGenie]
synonym: "ganglion spinalis morphogenesis" EXACT [GOC:TermGenie]
synonym: "posterior root ganglion morphogenesis" RELATED [GOC:TermGenie]
synonym: "spinal ganglion morphogenesis" EXACT [GOC:TermGenie]
synonym: "spinal ganglion part of peripheral nervous system morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:0061552 ! ganglion morphogenesis
relationship: part_of GO:1990791 ! dorsal root ganglion development
created_by: bf
creation_date: 2015-12-01T16:41:17Z

[Term]
id: GO:1904836
name: facioacoustic ganglion morphogenesis
namespace: biological_process
def: "The developmental process by which an acoustico-facial VII-VIII ganglion complex is generated and organized." [GO_REF:0000083, GOC:bf, GOC:mat, GOC:PARL, GOC:TermGenie, PMID:18356247]
synonym: "acoustico-facial VII-VIII ganglion complex morphogenesis" EXACT [UBERON:0012175]
synonym: "acousticofacial ganglion morphogenesis" EXACT [GOC:TermGenie]
synonym: "facio-acoustic ganglion complex morphogenesis" RELATED [GOC:TermGenie]
synonym: "facio-acoustic ganglion complex VII-VIII morphogenesis" EXACT [GOC:TermGenie]
synonym: "facio-acoustic ganglion morphogenesis" EXACT [GOC:TermGenie]
synonym: "facio-acoustic VII-VIII ganglion complex morphogenesis" RELATED [GOC:TermGenie]
is_a: GO:0061559 ! cranial ganglion morphogenesis
relationship: part_of GO:1903375 ! facioacoustic ganglion development
created_by: bf
creation_date: 2015-12-01T17:02:06Z

[Term]
id: GO:1904837
name: beta-catenin-TCF complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a beta-catenin-TCF complex." [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18936100]
synonym: "beta-catenin-TCF complex formation" EXACT [GOC:TermGenie]
synonym: "beta-catenin/LEF complex assembly" NARROW [GOC:TermGenie]
synonym: "beta-catenin/LEF complex formation" NARROW [GOC:TermGenie]
synonym: "beta-catenin/lymphoid enhancer binding factor complex assembly" RELATED [GOC:TermGenie]
synonym: "beta-catenin/lymphoid enhancer binding factor complex formation" RELATED [GOC:TermGenie]
synonym: "beta-catenin/T-cell factor complex assembly" RELATED [GOC:TermGenie]
synonym: "beta-catenin/T-cell factor complex formation" RELATED [GOC:TermGenie]
is_a: GO:0006461 ! protein complex assembly
created_by: bf
creation_date: 2015-12-03T17:20:26Z

[Term]
id: GO:1904838
name: regulation of male germ-line stem cell asymmetric division
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of male germ-line stem cell asymmetric division." [GO_REF:0000058, GOC:TermGenie, PMID:19339709]
synonym: "regulation of male germ-line stem cell renewal" EXACT [GOC:TermGenie]
is_a: GO:0009786 ! regulation of asymmetric cell division
is_a: GO:0043900 ! regulation of multi-organism process
is_a: GO:0051239 ! regulation of multicellular organismal process
is_a: GO:0060284 ! regulation of cell development
is_a: GO:2000035 ! regulation of stem cell division
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048133 ! male germ-line stem cell asymmetric division
relationship: regulates GO:0048133 ! male germ-line stem cell asymmetric division
created_by: sl
creation_date: 2015-12-05T00:28:31Z

[Term]
id: GO:1904839
name: negative regulation of male germ-line stem cell asymmetric division
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of male germ-line stem cell asymmetric division." [GO_REF:0000058, GOC:TermGenie, PMID:19339709]
synonym: "down regulation of male germ-line stem cell asymmetric division" EXACT [GOC:TermGenie]
synonym: "down regulation of male germ-line stem cell renewal" EXACT [GOC:TermGenie]
synonym: "down-regulation of male germ-line stem cell asymmetric division" EXACT [GOC:TermGenie]
synonym: "down-regulation of male germ-line stem cell renewal" EXACT [GOC:TermGenie]
synonym: "downregulation of male germ-line stem cell asymmetric division" EXACT [GOC:TermGenie]
synonym: "downregulation of male germ-line stem cell renewal" EXACT [GOC:TermGenie]
synonym: "inhibition of male germ-line stem cell asymmetric division" NARROW [GOC:TermGenie]
synonym: "inhibition of male germ-line stem cell renewal" NARROW [GOC:TermGenie]
synonym: "negative regulation of male germ-line stem cell renewal" EXACT [GOC:TermGenie]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0043901 ! negative regulation of multi-organism process
is_a: GO:0045769 ! negative regulation of asymmetric cell division
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1904838 ! regulation of male germ-line stem cell asymmetric division
is_a: GO:2000242 ! negative regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048133 ! male germ-line stem cell asymmetric division
relationship: negatively_regulates GO:0048133 ! male germ-line stem cell asymmetric division
created_by: sl
creation_date: 2015-12-05T00:28:39Z

[Term]
id: GO:1904840
name: positive regulation of male germ-line stem cell asymmetric division
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of male germ-line stem cell asymmetric division." [GO_REF:0000058, GOC:TermGenie, PMID:19339709]
synonym: "activation of male germ-line stem cell asymmetric division" NARROW [GOC:TermGenie]
synonym: "activation of male germ-line stem cell renewal" NARROW [GOC:TermGenie]
synonym: "positive regulation of male germ-line stem cell renewal" EXACT [GOC:TermGenie]
synonym: "up regulation of male germ-line stem cell asymmetric division" EXACT [GOC:TermGenie]
synonym: "up regulation of male germ-line stem cell renewal" EXACT [GOC:TermGenie]
synonym: "up-regulation of male germ-line stem cell asymmetric division" EXACT [GOC:TermGenie]
synonym: "up-regulation of male germ-line stem cell renewal" EXACT [GOC:TermGenie]
synonym: "upregulation of male germ-line stem cell asymmetric division" EXACT [GOC:TermGenie]
synonym: "upregulation of male germ-line stem cell renewal" EXACT [GOC:TermGenie]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0043902 ! positive regulation of multi-organism process
is_a: GO:0045770 ! positive regulation of asymmetric cell division
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1904838 ! regulation of male germ-line stem cell asymmetric division
is_a: GO:2000243 ! positive regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048133 ! male germ-line stem cell asymmetric division
relationship: positively_regulates GO:0048133 ! male germ-line stem cell asymmetric division
created_by: sl
creation_date: 2015-12-05T00:28:46Z

[Term]
id: GO:1904841
name: TORC2 complex binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a TORC2 complex." [GO_REF:000102, GOC:TermGenie, Pubmed:20660630]
comment: Interacting selectively and non-covalently with a TORC2 complex, a protein complex that mediates the phosphorylation of protein kinase B
synonym: "mTORC2 binding" NARROW [GOC:TermGenie]
synonym: "rapamycin and nutrient-insensitive TOR complex binding" EXACT [GOC:TermGenie]
synonym: "TOR complex 2 binding" EXACT [GOC:TermGenie]
synonym: "TORC 2 complex binding" EXACT [GOC:TermGenie]
synonym: "TORC2 binding" EXACT [GOC:TermGenie]
is_a: GO:0032403 ! protein complex binding
created_by: pf
creation_date: 2015-12-07T16:59:44Z

[Term]
id: GO:1904842
name: response to nitroglycerin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitroglycerin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:25626975]
synonym: "response to nitroglycerine" EXACT []
synonym: "response to nitroglycerol" EXACT []
synonym: "response to trinitroglycerin" EXACT []
synonym: "response to trinitroglycerol" EXACT []
is_a: GO:0010033 ! response to organic substance
is_a: GO:0042493 ! response to drug
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: sl
creation_date: 2015-12-07T18:30:47Z

[Term]
id: GO:1904843
name: cellular response to nitroglycerin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitroglycerin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:25626975]
synonym: "cellular response to nitroglycerine" EXACT []
synonym: "cellular response to nitroglycerol" EXACT []
synonym: "cellular response to trinitroglycerin" EXACT []
synonym: "cellular response to trinitroglycerol" EXACT []
is_a: GO:0035690 ! cellular response to drug
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1904842 ! response to nitroglycerin
created_by: sl
creation_date: 2015-12-07T18:30:55Z

[Term]
id: GO:1904844
name: response to L-glutamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-glutamine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23185570]
is_a: GO:0043200 ! response to amino acid
created_by: sl
creation_date: 2015-12-07T19:39:17Z

[Term]
id: GO:1904845
name: cellular response to L-glutamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-glutamine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23185570]
is_a: GO:0071230 ! cellular response to amino acid stimulus
is_a: GO:1904844 ! response to L-glutamine
created_by: sl
creation_date: 2015-12-07T19:39:24Z

[Term]
id: GO:1904846
name: negative regulation of establishment of bipolar cell polarity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of bipolar cell polarity." [GO_REF:0000058, GOC:TermGenie, PMID:26525038]
synonym: "down regulation of establishment of bipolar cell polarity" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of bipolar cell polarity" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of bipolar cell polarity" EXACT [GOC:TermGenie]
synonym: "inhibition of establishment of bipolar cell polarity" NARROW [GOC:TermGenie]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0061172 ! regulation of establishment of bipolar cell polarity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061171 ! establishment of bipolar cell polarity
relationship: negatively_regulates GO:0061171 ! establishment of bipolar cell polarity
created_by: al
creation_date: 2015-12-08T15:06:30Z

[Term]
id: GO:1904847
name: regulation of cell chemotaxis to fibroblast growth factor
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell chemotaxis to fibroblast growth factor." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23233752]
is_a: GO:0030334 ! regulation of cell migration
is_a: GO:0050920 ! regulation of chemotaxis
is_a: GO:0090287 ! regulation of cellular response to growth factor stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035766 ! cell chemotaxis to fibroblast growth factor
relationship: regulates GO:0035766 ! cell chemotaxis to fibroblast growth factor
created_by: rph
creation_date: 2015-12-10T12:04:01Z

[Term]
id: GO:1904848
name: negative regulation of cell chemotaxis to fibroblast growth factor
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell chemotaxis to fibroblast growth factor." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23233752]
synonym: "down regulation of cell chemotaxis to fibroblast growth factor" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell chemotaxis to fibroblast growth factor" EXACT [GOC:TermGenie]
synonym: "downregulation of cell chemotaxis to fibroblast growth factor" EXACT [GOC:TermGenie]
synonym: "inhibition of cell chemotaxis to fibroblast growth factor" NARROW [GOC:TermGenie]
is_a: GO:0030336 ! negative regulation of cell migration
is_a: GO:0050922 ! negative regulation of chemotaxis
is_a: GO:0090288 ! negative regulation of cellular response to growth factor stimulus
is_a: GO:1904847 ! regulation of cell chemotaxis to fibroblast growth factor
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035766 ! cell chemotaxis to fibroblast growth factor
relationship: negatively_regulates GO:0035766 ! cell chemotaxis to fibroblast growth factor
created_by: rph
creation_date: 2015-12-10T12:04:08Z

[Term]
id: GO:1904849
name: positive regulation of cell chemotaxis to fibroblast growth factor
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell chemotaxis to fibroblast growth factor." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23233752]
synonym: "activation of cell chemotaxis to fibroblast growth factor" NARROW [GOC:TermGenie]
synonym: "up regulation of cell chemotaxis to fibroblast growth factor" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell chemotaxis to fibroblast growth factor" EXACT [GOC:TermGenie]
synonym: "upregulation of cell chemotaxis to fibroblast growth factor" EXACT [GOC:TermGenie]
is_a: GO:0030335 ! positive regulation of cell migration
is_a: GO:0050921 ! positive regulation of chemotaxis
is_a: GO:1904847 ! regulation of cell chemotaxis to fibroblast growth factor
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035766 ! cell chemotaxis to fibroblast growth factor
relationship: positively_regulates GO:0035766 ! cell chemotaxis to fibroblast growth factor
created_by: rph
creation_date: 2015-12-10T12:04:16Z

[Term]
id: GO:1904850
name: negative regulation of establishment of protein localization to telomere
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization to telomere." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444]
synonym: "down regulation of establishment of protein localisation to telomere" EXACT [GOC:TermGenie]
synonym: "down regulation of establishment of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie]
synonym: "down regulation of establishment of protein localization to telomere" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of protein localisation to telomere" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of protein localization to telomere" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of protein localisation to telomere" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of protein localization to telomere" EXACT [GOC:TermGenie]
synonym: "inhibition of establishment of protein localisation to telomere" NARROW [GOC:TermGenie]
synonym: "inhibition of establishment of protein localization to chromosome, telomeric region" NARROW [GOC:TermGenie]
synonym: "inhibition of establishment of protein localization to telomere" NARROW [GOC:TermGenie]
synonym: "negative regulation of establishment of protein localisation to telomere" EXACT [GOC:TermGenie]
synonym: "negative regulation of establishment of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie]
is_a: GO:0070203 ! regulation of establishment of protein localization to telomere
is_a: GO:1904815 ! negative regulation of protein localization to chromosome, telomeric region
is_a: GO:1904950 ! negative regulation of establishment of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070200 ! establishment of protein localization to telomere
relationship: negatively_regulates GO:0070200 ! establishment of protein localization to telomere
created_by: nc
creation_date: 2015-12-10T15:37:51Z

[Term]
id: GO:1904851
name: positive regulation of establishment of protein localization to telomere
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment of protein localization to telomere." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444]
synonym: "activation of establishment of protein localisation to telomere" NARROW [GOC:TermGenie]
synonym: "activation of establishment of protein localization to chromosome, telomeric region" NARROW [GOC:TermGenie]
synonym: "activation of establishment of protein localization to telomere" NARROW [GOC:TermGenie]
synonym: "positive regulation of establishment of protein localisation to telomere" EXACT [GOC:TermGenie]
synonym: "positive regulation of establishment of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of protein localisation to telomere" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of protein localization to telomere" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of protein localisation to telomere" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of protein localization to telomere" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of protein localisation to telomere" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of protein localization to telomere" EXACT [GOC:TermGenie]
is_a: GO:0070203 ! regulation of establishment of protein localization to telomere
is_a: GO:1904816 ! positive regulation of protein localization to chromosome, telomeric region
is_a: GO:1904951 ! positive regulation of establishment of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070200 ! establishment of protein localization to telomere
relationship: positively_regulates GO:0070200 ! establishment of protein localization to telomere
created_by: nc
creation_date: 2015-12-10T15:37:58Z

[Term]
id: GO:1904852
name: trimethylamine-N-oxide reductase (cytochrome c) complex
namespace: cellular_component
def: "A protein complex which is capable of trimethylamine-N-oxide reductase (cytochrome c) activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:11056172]
comment: An example of this is TorA in E. coli (UniProt ID P33225) in PMID:11056172 (inferred from direct assay).
is_a: GO:1990204 ! oxidoreductase complex
created_by: bhm
creation_date: 2015-12-14T09:11:10Z

[Term]
id: GO:1904853
name: protein localization to ascospore wall
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within an ascospore wall." [GO_REF:0000087, GOC:TermGenie, PMID:24623719]
synonym: "protein localisation in ascospore wall" EXACT [GOC:TermGenie]
synonym: "protein localisation to ascospore wall" EXACT [GOC:TermGenie]
synonym: "protein localization in ascospore wall" EXACT [GOC:TermGenie]
is_a: GO:1990778 ! protein localization to cell periphery
created_by: mah
creation_date: 2015-12-14T12:52:50Z

[Term]
id: GO:1904854
name: proteasome core complex binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a proteasome core complex." [GO_REF:000102, GOC:TermGenie, PMID:16096059]
synonym: "20S core complex binding" NARROW [GOC:TermGenie]
synonym: "20S proteasome binding" NARROW [GOC:TermGenie]
synonym: "macropain binding" EXACT [GOC:TermGenie]
synonym: "PA28gamma-20S proteasome binding" NARROW [GOC:TermGenie]
is_a: GO:0032403 ! protein complex binding
created_by: mah
creation_date: 2015-12-15T11:54:19Z

[Term]
id: GO:1904855
name: proteasome regulatory particle binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a proteasome regulatory particle." [GO_REF:000102, GOC:TermGenie, PMID:16096059]
synonym: "19S regulatory particle binding" NARROW [GOC:TermGenie]
synonym: "modulator complex binding" RELATED [GOC:TermGenie]
synonym: "PA700 proteasome activator binding" NARROW [GOC:TermGenie]
synonym: "PA700-dependent proteasome activator binding" EXACT [GOC:TermGenie]
is_a: GO:0032403 ! protein complex binding
created_by: mah
creation_date: 2015-12-15T11:54:27Z

[Term]
id: GO:1904856
name: cytolytic granule lumen
namespace: cellular_component
def: "Any cytoplasmic membrane-bounded vesicle lumen that is part of a cytolytic granule." [GO_REF:0000064, GOC:TermGenie, PMID:17272266, PMID:21247065]
synonym: "cytolytic granule cytoplasmic membrane-bounded vesicle lumen" EXACT []
synonym: "cytoplasmic membrane-bounded vesicle lumen of cytolytic granule" EXACT [GOC:TermGenie]
synonym: "cytoplasmic membrane-enclosed vesicle lumen of cytolytic granule" EXACT [GOC:TermGenie]
is_a: GO:0005775 ! vacuolar lumen
is_a: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen
intersection_of: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen
intersection_of: part_of GO:0044194 ! cytolytic granule
relationship: part_of GO:0044194 ! cytolytic granule
created_by: mec
creation_date: 2015-12-15T12:51:17Z

[Term]
id: GO:1904857
name: regulation of endothelial cell chemotaxis to vascular endothelial growth factor
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endothelial cell chemotaxis to vascular endothelial growth factor." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:21885851]
is_a: GO:0030334 ! regulation of cell migration
is_a: GO:0050920 ! regulation of chemotaxis
is_a: GO:1902547 ! regulation of cellular response to vascular endothelial growth factor stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0090668 ! endothelial cell chemotaxis to vascular endothelial growth factor
relationship: regulates GO:0090668 ! endothelial cell chemotaxis to vascular endothelial growth factor
created_by: rph
creation_date: 2015-12-16T11:47:44Z

[Term]
id: GO:1904858
name: negative regulation of endothelial cell chemotaxis to vascular endothelial growth factor
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell chemotaxis to vascular endothelial growth factor." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:21885851]
synonym: "down regulation of endothelial cell chemotaxis to vascular endothelial growth factor" EXACT [GOC:TermGenie]
synonym: "down-regulation of endothelial cell chemotaxis to vascular endothelial growth factor" EXACT [GOC:TermGenie]
synonym: "downregulation of endothelial cell chemotaxis to vascular endothelial growth factor" EXACT [GOC:TermGenie]
synonym: "inhibition of endothelial cell chemotaxis to vascular endothelial growth factor" NARROW [GOC:TermGenie]
is_a: GO:0030336 ! negative regulation of cell migration
is_a: GO:0050922 ! negative regulation of chemotaxis
is_a: GO:1902548 ! negative regulation of cellular response to vascular endothelial growth factor stimulus
is_a: GO:1904857 ! regulation of endothelial cell chemotaxis to vascular endothelial growth factor
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0090668 ! endothelial cell chemotaxis to vascular endothelial growth factor
relationship: negatively_regulates GO:0090668 ! endothelial cell chemotaxis to vascular endothelial growth factor
created_by: rph
creation_date: 2015-12-16T11:47:52Z

[Term]
id: GO:1904859
name: positive regulation of endothelial cell chemotaxis to vascular endothelial growth factor
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis to vascular endothelial growth factor." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:21885851]
synonym: "activation of endothelial cell chemotaxis to vascular endothelial growth factor" NARROW [GOC:TermGenie]
synonym: "up regulation of endothelial cell chemotaxis to vascular endothelial growth factor" EXACT [GOC:TermGenie]
synonym: "up-regulation of endothelial cell chemotaxis to vascular endothelial growth factor" EXACT [GOC:TermGenie]
synonym: "upregulation of endothelial cell chemotaxis to vascular endothelial growth factor" EXACT [GOC:TermGenie]
is_a: GO:0030335 ! positive regulation of cell migration
is_a: GO:0050921 ! positive regulation of chemotaxis
is_a: GO:1904857 ! regulation of endothelial cell chemotaxis to vascular endothelial growth factor
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0090668 ! endothelial cell chemotaxis to vascular endothelial growth factor
relationship: positively_regulates GO:0090668 ! endothelial cell chemotaxis to vascular endothelial growth factor
created_by: rph
creation_date: 2015-12-16T11:48:00Z

[Term]
id: GO:1904860
name: DNA biosynthetic process involved in mitotic DNA replication
namespace: biological_process
def: "Any DNA biosynthetic process that is involved in mitotic DNA replication." [GO_REF:0000060, GOC:TermGenie, PMID:16849602]
synonym: "DNA anabolism involved in DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "DNA anabolism involved in DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "DNA anabolism involved in DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "DNA anabolism involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "DNA anabolism involved in mitotic DNA replication" EXACT [GOC:TermGenie]
synonym: "DNA anabolism involved in mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "DNA anabolism involved in nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "DNA biosynthesis involved in DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "DNA biosynthesis involved in DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "DNA biosynthesis involved in DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "DNA biosynthesis involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "DNA biosynthesis involved in mitotic DNA replication" EXACT [GOC:TermGenie]
synonym: "DNA biosynthesis involved in mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "DNA biosynthesis involved in nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "DNA biosynthetic process involved in DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "DNA biosynthetic process involved in DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "DNA biosynthetic process involved in DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "DNA biosynthetic process involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "DNA biosynthetic process involved in mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "DNA biosynthetic process involved in nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "DNA formation involved in DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "DNA formation involved in DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "DNA formation involved in DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "DNA formation involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "DNA formation involved in mitotic DNA replication" EXACT [GOC:TermGenie]
synonym: "DNA formation involved in mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "DNA formation involved in nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "DNA synthesis involved in DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie]
synonym: "DNA synthesis involved in DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "DNA synthesis involved in DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "DNA synthesis involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "DNA synthesis involved in mitotic DNA replication" EXACT [GOC:TermGenie]
synonym: "DNA synthesis involved in mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie]
synonym: "DNA synthesis involved in nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie]
is_a: GO:0044711 ! single-organism biosynthetic process
is_a: GO:0090592 ! DNA synthesis involved in DNA replication
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0071897 ! DNA biosynthetic process
intersection_of: part_of GO:1902969 ! mitotic DNA replication
relationship: part_of GO:1902969 ! mitotic DNA replication
created_by: mah
creation_date: 2015-12-16T12:02:37Z

[Term]
id: GO:1904861
name: excitatory synapse assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an excitatory synapse." [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21670302]
synonym: "excitatory synapse formation" EXACT [GOC:TermGenie]
is_a: GO:0007416 ! synapse assembly
created_by: bf
creation_date: 2015-12-17T10:31:26Z

[Term]
id: GO:1904862
name: inhibitory synapse assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an inhibitory synapse." [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "inhibitory synapse formation" EXACT [GOC:TermGenie]
is_a: GO:0007416 ! synapse assembly
created_by: bf
creation_date: 2015-12-17T10:31:34Z

[Term]
id: GO:1904863
name: regulation of beta-catenin-TCF complex assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of beta-catenin-TCF complex assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "regulation of beta-catenin-TCF complex formation" EXACT [GOC:TermGenie]
synonym: "regulation of beta-catenin/LEF complex assembly" NARROW [GOC:TermGenie]
synonym: "regulation of beta-catenin/LEF complex formation" NARROW [GOC:TermGenie]
synonym: "regulation of beta-catenin/lymphoid enhancer binding factor complex assembly" RELATED [GOC:TermGenie]
synonym: "regulation of beta-catenin/lymphoid enhancer binding factor complex formation" RELATED [GOC:TermGenie]
synonym: "regulation of beta-catenin/T-cell factor complex assembly" RELATED [GOC:TermGenie]
synonym: "regulation of beta-catenin/T-cell factor complex formation" RELATED [GOC:TermGenie]
is_a: GO:0043254 ! regulation of protein complex assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1904837 ! beta-catenin-TCF complex assembly
relationship: regulates GO:1904837 ! beta-catenin-TCF complex assembly
created_by: bf
creation_date: 2015-12-17T13:50:39Z

[Term]
id: GO:1904864
name: negative regulation of beta-catenin-TCF complex assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of beta-catenin-TCF complex assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18936100]
synonym: "down regulation of beta-catenin-TCF complex assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of beta-catenin-TCF complex formation" EXACT [GOC:TermGenie]
synonym: "down regulation of beta-catenin/LEF complex assembly" NARROW [GOC:TermGenie]
synonym: "down regulation of beta-catenin/LEF complex formation" NARROW [GOC:TermGenie]
synonym: "down regulation of beta-catenin/lymphoid enhancer binding factor complex assembly" RELATED [GOC:TermGenie]
synonym: "down regulation of beta-catenin/lymphoid enhancer binding factor complex formation" RELATED [GOC:TermGenie]
synonym: "down regulation of beta-catenin/T-cell factor complex assembly" RELATED [GOC:TermGenie]
synonym: "down regulation of beta-catenin/T-cell factor complex formation" RELATED [GOC:TermGenie]
synonym: "down-regulation of beta-catenin-TCF complex assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of beta-catenin-TCF complex formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of beta-catenin/LEF complex assembly" NARROW [GOC:TermGenie]
synonym: "down-regulation of beta-catenin/LEF complex formation" NARROW [GOC:TermGenie]
synonym: "down-regulation of beta-catenin/lymphoid enhancer binding factor complex assembly" RELATED [GOC:TermGenie]
synonym: "down-regulation of beta-catenin/lymphoid enhancer binding factor complex formation" RELATED [GOC:TermGenie]
synonym: "down-regulation of beta-catenin/T-cell factor complex assembly" RELATED [GOC:TermGenie]
synonym: "down-regulation of beta-catenin/T-cell factor complex formation" RELATED [GOC:TermGenie]
synonym: "downregulation of beta-catenin-TCF complex assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of beta-catenin-TCF complex formation" EXACT [GOC:TermGenie]
synonym: "downregulation of beta-catenin/LEF complex assembly" NARROW [GOC:TermGenie]
synonym: "downregulation of beta-catenin/LEF complex formation" NARROW [GOC:TermGenie]
synonym: "downregulation of beta-catenin/lymphoid enhancer binding factor complex assembly" RELATED [GOC:TermGenie]
synonym: "downregulation of beta-catenin/lymphoid enhancer binding factor complex formation" RELATED [GOC:TermGenie]
synonym: "downregulation of beta-catenin/T-cell factor complex assembly" RELATED [GOC:TermGenie]
synonym: "downregulation of beta-catenin/T-cell factor complex formation" RELATED [GOC:TermGenie]
synonym: "inhibition of beta-catenin-TCF complex assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of beta-catenin-TCF complex formation" NARROW [GOC:TermGenie]
synonym: "inhibition of beta-catenin/LEF complex assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of beta-catenin/LEF complex formation" NARROW [GOC:TermGenie]
synonym: "inhibition of beta-catenin/lymphoid enhancer binding factor complex assembly" RELATED [GOC:TermGenie]
synonym: "inhibition of beta-catenin/lymphoid enhancer binding factor complex formation" RELATED [GOC:TermGenie]
synonym: "inhibition of beta-catenin/T-cell factor complex assembly" RELATED [GOC:TermGenie]
synonym: "inhibition of beta-catenin/T-cell factor complex formation" RELATED [GOC:TermGenie]
synonym: "negative regulation of beta-catenin-TCF complex formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of beta-catenin/LEF complex assembly" NARROW [GOC:TermGenie]
synonym: "negative regulation of beta-catenin/LEF complex formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of beta-catenin/lymphoid enhancer binding factor complex assembly" RELATED [GOC:TermGenie]
synonym: "negative regulation of beta-catenin/lymphoid enhancer binding factor complex formation" RELATED [GOC:TermGenie]
synonym: "negative regulation of beta-catenin/T-cell factor complex assembly" RELATED [GOC:TermGenie]
synonym: "negative regulation of beta-catenin/T-cell factor complex formation" RELATED [GOC:TermGenie]
is_a: GO:0031333 ! negative regulation of protein complex assembly
is_a: GO:1904863 ! regulation of beta-catenin-TCF complex assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1904837 ! beta-catenin-TCF complex assembly
relationship: negatively_regulates GO:1904837 ! beta-catenin-TCF complex assembly
created_by: bf
creation_date: 2015-12-17T13:50:46Z

[Term]
id: GO:1904865
name: positive regulation of beta-catenin-TCF complex assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of beta-catenin-TCF complex assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "activation of beta-catenin-TCF complex assembly" NARROW [GOC:TermGenie]
synonym: "activation of beta-catenin-TCF complex formation" NARROW [GOC:TermGenie]
synonym: "activation of beta-catenin/LEF complex assembly" NARROW [GOC:TermGenie]
synonym: "activation of beta-catenin/LEF complex formation" NARROW [GOC:TermGenie]
synonym: "activation of beta-catenin/lymphoid enhancer binding factor complex assembly" RELATED [GOC:TermGenie]
synonym: "activation of beta-catenin/lymphoid enhancer binding factor complex formation" RELATED [GOC:TermGenie]
synonym: "activation of beta-catenin/T-cell factor complex assembly" RELATED [GOC:TermGenie]
synonym: "activation of beta-catenin/T-cell factor complex formation" RELATED [GOC:TermGenie]
synonym: "positive regulation of beta-catenin-TCF complex formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of beta-catenin/LEF complex assembly" NARROW [GOC:TermGenie]
synonym: "positive regulation of beta-catenin/LEF complex formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of beta-catenin/lymphoid enhancer binding factor complex assembly" RELATED [GOC:TermGenie]
synonym: "positive regulation of beta-catenin/lymphoid enhancer binding factor complex formation" RELATED [GOC:TermGenie]
synonym: "positive regulation of beta-catenin/T-cell factor complex assembly" RELATED [GOC:TermGenie]
synonym: "positive regulation of beta-catenin/T-cell factor complex formation" RELATED [GOC:TermGenie]
synonym: "up regulation of beta-catenin-TCF complex assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of beta-catenin-TCF complex formation" EXACT [GOC:TermGenie]
synonym: "up regulation of beta-catenin/LEF complex assembly" NARROW [GOC:TermGenie]
synonym: "up regulation of beta-catenin/LEF complex formation" NARROW [GOC:TermGenie]
synonym: "up regulation of beta-catenin/lymphoid enhancer binding factor complex assembly" RELATED [GOC:TermGenie]
synonym: "up regulation of beta-catenin/lymphoid enhancer binding factor complex formation" RELATED [GOC:TermGenie]
synonym: "up regulation of beta-catenin/T-cell factor complex assembly" RELATED [GOC:TermGenie]
synonym: "up regulation of beta-catenin/T-cell factor complex formation" RELATED [GOC:TermGenie]
synonym: "up-regulation of beta-catenin-TCF complex assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of beta-catenin-TCF complex formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of beta-catenin/LEF complex assembly" NARROW [GOC:TermGenie]
synonym: "up-regulation of beta-catenin/LEF complex formation" NARROW [GOC:TermGenie]
synonym: "up-regulation of beta-catenin/lymphoid enhancer binding factor complex assembly" RELATED [GOC:TermGenie]
synonym: "up-regulation of beta-catenin/lymphoid enhancer binding factor complex formation" RELATED [GOC:TermGenie]
synonym: "up-regulation of beta-catenin/T-cell factor complex assembly" RELATED [GOC:TermGenie]
synonym: "up-regulation of beta-catenin/T-cell factor complex formation" RELATED [GOC:TermGenie]
synonym: "upregulation of beta-catenin-TCF complex assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of beta-catenin-TCF complex formation" EXACT [GOC:TermGenie]
synonym: "upregulation of beta-catenin/LEF complex assembly" NARROW [GOC:TermGenie]
synonym: "upregulation of beta-catenin/LEF complex formation" NARROW [GOC:TermGenie]
synonym: "upregulation of beta-catenin/lymphoid enhancer binding factor complex assembly" RELATED [GOC:TermGenie]
synonym: "upregulation of beta-catenin/lymphoid enhancer binding factor complex formation" RELATED [GOC:TermGenie]
synonym: "upregulation of beta-catenin/T-cell factor complex assembly" RELATED [GOC:TermGenie]
synonym: "upregulation of beta-catenin/T-cell factor complex formation" RELATED [GOC:TermGenie]
is_a: GO:0031334 ! positive regulation of protein complex assembly
is_a: GO:1904863 ! regulation of beta-catenin-TCF complex assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1904837 ! beta-catenin-TCF complex assembly
relationship: positively_regulates GO:1904837 ! beta-catenin-TCF complex assembly
created_by: bf
creation_date: 2015-12-17T13:50:53Z

[Term]
id: GO:1904866
name: ventral tegmental area development
namespace: biological_process
def: "The process whose specific outcome is the progression of a ventral tegmental area (VTA) over time, from its formation to the mature structure." [GO_REF:0000094, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:26548362]
synonym: "a10a development" EXACT [GOC:TermGenie]
synonym: "area tegmentalis ventralis (Tsai) development" RELATED [GOC:TermGenie]
synonym: "area tegmentalis ventralis development" RELATED [GOC:TermGenie]
synonym: "tegmentum ventrale development" RELATED [GOC:TermGenie]
synonym: "ventral brain stem development" RELATED [GOC:TermGenie]
synonym: "ventral tegmental area (Tsai) development" RELATED [GOC:TermGenie]
synonym: "ventral tegmental area of tsai development" EXACT [GOC:TermGenie]
synonym: "ventral tegmental nucleus (Rioch) development" RELATED [GOC:TermGenie]
synonym: "ventral tegmental nucleus (tsai) development" EXACT [GOC:TermGenie]
synonym: "ventral tegmental nucleus of tsai development" EXACT [GOC:TermGenie]
synonym: "ventral tegmentum development" EXACT [Wikipedia:Ventral_tegmental_area]
synonym: "ventromedial mesencephalic tegmentum development" RELATED [GOC:TermGenie]
synonym: "VTA development" BROAD [GOC:TermGenie]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0030901 ! midbrain development
created_by: bf
creation_date: 2015-12-17T14:44:18Z

[Term]
id: GO:1904867
name: protein localization to Cajal body
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a Cajal body." [GO_REF:0000087, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444]
synonym: "protein localisation in Cajal body" EXACT [GOC:TermGenie]
synonym: "protein localisation to Cajal body" EXACT [GOC:TermGenie]
synonym: "protein localization in Cajal body" EXACT [GOC:TermGenie]
is_a: GO:1903405 ! protein localization to nuclear body
created_by: tb
creation_date: 2015-12-17T21:48:18Z

[Term]
id: GO:1904868
name: telomerase catalytic core complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a telomerase catalytic core complex." [GO_REF:0000079, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26586433]
synonym: "telomerase catalytic core complex formation" EXACT [GOC:TermGenie]
synonym: "TERT-TERC complex assembly" RELATED [GOC:TermGenie]
synonym: "TERT-TERC complex formation" RELATED [GOC:TermGenie]
is_a: GO:0022618 ! ribonucleoprotein complex assembly
created_by: rph
creation_date: 2015-12-18T10:02:45Z

[Term]
id: GO:1904869
name: regulation of protein localization to Cajal body
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444]
synonym: "regulation of protein localisation in Cajal body" EXACT [GOC:TermGenie]
synonym: "regulation of protein localisation to Cajal body" EXACT [GOC:TermGenie]
synonym: "regulation of protein localization in Cajal body" EXACT [GOC:TermGenie]
is_a: GO:1900180 ! regulation of protein localization to nucleus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1904867 ! protein localization to Cajal body
relationship: regulates GO:1904867 ! protein localization to Cajal body
created_by: nc
creation_date: 2015-12-18T11:17:31Z

[Term]
id: GO:1904870
name: negative regulation of protein localization to Cajal body
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444]
synonym: "down regulation of protein localisation in Cajal body" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localisation to Cajal body" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization in Cajal body" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to Cajal body" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation in Cajal body" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation to Cajal body" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization in Cajal body" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to Cajal body" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation in Cajal body" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation to Cajal body" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization in Cajal body" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to Cajal body" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localisation in Cajal body" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localisation to Cajal body" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization in Cajal body" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to Cajal body" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation in Cajal body" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localisation to Cajal body" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localization in Cajal body" EXACT [GOC:TermGenie]
is_a: GO:1900181 ! negative regulation of protein localization to nucleus
is_a: GO:1904869 ! regulation of protein localization to Cajal body
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1904867 ! protein localization to Cajal body
relationship: negatively_regulates GO:1904867 ! protein localization to Cajal body
created_by: nc
creation_date: 2015-12-18T11:17:38Z

[Term]
id: GO:1904871
name: positive regulation of protein localization to Cajal body
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444]
synonym: "activation of protein localisation in Cajal body" NARROW [GOC:TermGenie]
synonym: "activation of protein localisation to Cajal body" NARROW [GOC:TermGenie]
synonym: "activation of protein localization in Cajal body" NARROW [GOC:TermGenie]
synonym: "activation of protein localization to Cajal body" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein localisation in Cajal body" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localisation to Cajal body" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localization in Cajal body" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation in Cajal body" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation to Cajal body" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization in Cajal body" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to Cajal body" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation in Cajal body" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation to Cajal body" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization in Cajal body" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to Cajal body" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation in Cajal body" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation to Cajal body" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization in Cajal body" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to Cajal body" EXACT [GOC:TermGenie]
is_a: GO:1900182 ! positive regulation of protein localization to nucleus
is_a: GO:1904869 ! regulation of protein localization to Cajal body
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1904867 ! protein localization to Cajal body
relationship: positively_regulates GO:1904867 ! protein localization to Cajal body
created_by: nc
creation_date: 2015-12-18T11:17:45Z

[Term]
id: GO:1904872
name: regulation of telomerase RNA localization to Cajal body
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of telomerase RNA localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444]
is_a: GO:0032879 ! regulation of localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0090671 ! telomerase RNA localization to Cajal body
relationship: regulates GO:0090671 ! telomerase RNA localization to Cajal body
created_by: nc
creation_date: 2015-12-18T11:28:20Z

[Term]
id: GO:1904873
name: negative regulation of telomerase RNA localization to Cajal body
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of telomerase RNA localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444]
synonym: "down regulation of telomerase RNA localization to Cajal body" EXACT [GOC:TermGenie]
synonym: "down-regulation of telomerase RNA localization to Cajal body" EXACT [GOC:TermGenie]
synonym: "downregulation of telomerase RNA localization to Cajal body" EXACT [GOC:TermGenie]
synonym: "inhibition of telomerase RNA localization to Cajal body" NARROW [GOC:TermGenie]
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:1904872 ! regulation of telomerase RNA localization to Cajal body
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0090671 ! telomerase RNA localization to Cajal body
relationship: negatively_regulates GO:0090671 ! telomerase RNA localization to Cajal body
created_by: nc
creation_date: 2015-12-18T11:28:27Z

[Term]
id: GO:1904874
name: positive regulation of telomerase RNA localization to Cajal body
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of telomerase RNA localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444]
synonym: "activation of telomerase RNA localization to Cajal body" NARROW [GOC:TermGenie]
synonym: "up regulation of telomerase RNA localization to Cajal body" EXACT [GOC:TermGenie]
synonym: "up-regulation of telomerase RNA localization to Cajal body" EXACT [GOC:TermGenie]
synonym: "upregulation of telomerase RNA localization to Cajal body" EXACT [GOC:TermGenie]
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:1904872 ! regulation of telomerase RNA localization to Cajal body
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0090671 ! telomerase RNA localization to Cajal body
relationship: positively_regulates GO:0090671 ! telomerase RNA localization to Cajal body
created_by: nc
creation_date: 2015-12-18T11:28:34Z

[Term]
id: GO:1904875
name: regulation of DNA ligase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA ligase activity." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:rl, GOC:TermGenie, PMID:17389648]
is_a: GO:0051105 ! regulation of DNA ligation
is_a: GO:0051340 ! regulation of ligase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003909 ! DNA ligase activity
relationship: regulates GO:0003909 ! DNA ligase activity
created_by: rl
creation_date: 2015-12-18T18:35:30Z

[Term]
id: GO:1904876
name: negative regulation of DNA ligase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA ligase activity." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:rl, GOC:TermGenie, PMID:17389648]
synonym: "down regulation of DNA ligase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA ligase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA ligase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of DNA ligase activity" NARROW [GOC:TermGenie]
is_a: GO:0051107 ! negative regulation of DNA ligation
is_a: GO:0051352 ! negative regulation of ligase activity
is_a: GO:1904875 ! regulation of DNA ligase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003909 ! DNA ligase activity
relationship: negatively_regulates GO:0003909 ! DNA ligase activity
created_by: rl
creation_date: 2015-12-18T18:35:37Z

[Term]
id: GO:1904877
name: positive regulation of DNA ligase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA ligase activity." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:rl, GOC:TermGenie, PMID:17389648]
synonym: "activation of DNA ligase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of DNA ligase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA ligase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA ligase activity" EXACT [GOC:TermGenie]
is_a: GO:0051106 ! positive regulation of DNA ligation
is_a: GO:0051351 ! positive regulation of ligase activity
is_a: GO:1904875 ! regulation of DNA ligase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003909 ! DNA ligase activity
relationship: positively_regulates GO:0003909 ! DNA ligase activity
created_by: rl
creation_date: 2015-12-18T18:35:44Z

[Term]
id: GO:1904878
name: negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion transmembrane transport via high voltage-gated calcium channel." [GO_REF:0000058, GOC:TermGenie, PMID:23071515]
synonym: "down regulation of generation of L-type calcium current" EXACT [GOC:TermGenie]
synonym: "down-regulation of generation of L-type calcium current" EXACT [GOC:TermGenie]
synonym: "downregulation of generation of L-type calcium current" EXACT [GOC:TermGenie]
synonym: "inhibition of generation of L-type calcium current" NARROW [GOC:TermGenie]
synonym: "negative regulation of generation of L-type calcium current" RELATED []
is_a: GO:1902514 ! regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
is_a: GO:1903170 ! negative regulation of calcium ion transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061577 ! calcium ion transmembrane transport via high voltage-gated calcium channel
relationship: negatively_regulates GO:0061577 ! calcium ion transmembrane transport via high voltage-gated calcium channel
created_by: sl
creation_date: 2015-12-18T22:30:37Z

[Term]
id: GO:1904879
name: positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of calcium ion transmembrane transport via high voltage-gated calcium channel." [GO_REF:0000058, GOC:TermGenie, PMID:23071515]
synonym: "activation of generation of L-type calcium current" NARROW [GOC:TermGenie]
synonym: "positive regulation of generation of L-type calcium current" RELATED []
synonym: "up regulation of generation of L-type calcium current" EXACT [GOC:TermGenie]
synonym: "up-regulation of generation of L-type calcium current" EXACT [GOC:TermGenie]
synonym: "upregulation of generation of L-type calcium current" EXACT [GOC:TermGenie]
is_a: GO:1902514 ! regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
is_a: GO:1904427 ! positive regulation of calcium ion transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061577 ! calcium ion transmembrane transport via high voltage-gated calcium channel
relationship: positively_regulates GO:0061577 ! calcium ion transmembrane transport via high voltage-gated calcium channel
created_by: sl
creation_date: 2015-12-18T22:30:44Z

[Term]
id: GO:1904880
name: response to hydrogen sulfide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen sulfide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24012591]
synonym: "response to dihydridosulfur" EXACT []
synonym: "response to sulfane" EXACT []
is_a: GO:0001101 ! response to acid chemical
is_a: GO:0010035 ! response to inorganic substance
created_by: sl
creation_date: 2016-01-04T23:56:27Z

[Term]
id: GO:1904881
name: cellular response to hydrogen sulfide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen sulfide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24012591]
synonym: "cellular response to dihydridosulfur" EXACT []
synonym: "cellular response to sulfane" EXACT []
is_a: GO:0071229 ! cellular response to acid chemical
is_a: GO:1904880 ! response to hydrogen sulfide
created_by: sl
creation_date: 2016-01-04T23:56:35Z

[Term]
id: GO:1904882
name: regulation of telomerase catalytic core complex assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of telomerase catalytic core complex assembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26586433]
synonym: "regulation of telomerase catalytic core complex formation" EXACT [GOC:TermGenie]
synonym: "regulation of TERT-TERC complex assembly" RELATED [GOC:TermGenie]
synonym: "regulation of TERT-TERC complex formation" RELATED [GOC:TermGenie]
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1904868 ! telomerase catalytic core complex assembly
relationship: regulates GO:1904868 ! telomerase catalytic core complex assembly
created_by: rph
creation_date: 2016-01-05T10:36:01Z

[Term]
id: GO:1904883
name: negative regulation of telomerase catalytic core complex assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of telomerase catalytic core complex assembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26586433]
synonym: "down regulation of telomerase catalytic core complex assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of telomerase catalytic core complex formation" EXACT [GOC:TermGenie]
synonym: "down regulation of TERT-TERC complex assembly" RELATED [GOC:TermGenie]
synonym: "down regulation of TERT-TERC complex formation" RELATED [GOC:TermGenie]
synonym: "down-regulation of telomerase catalytic core complex assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of telomerase catalytic core complex formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of TERT-TERC complex assembly" RELATED [GOC:TermGenie]
synonym: "down-regulation of TERT-TERC complex formation" RELATED [GOC:TermGenie]
synonym: "downregulation of telomerase catalytic core complex assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of telomerase catalytic core complex formation" EXACT [GOC:TermGenie]
synonym: "downregulation of TERT-TERC complex assembly" RELATED [GOC:TermGenie]
synonym: "downregulation of TERT-TERC complex formation" RELATED [GOC:TermGenie]
synonym: "inhibition of telomerase catalytic core complex assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of telomerase catalytic core complex formation" NARROW [GOC:TermGenie]
synonym: "inhibition of TERT-TERC complex assembly" RELATED [GOC:TermGenie]
synonym: "inhibition of TERT-TERC complex formation" RELATED [GOC:TermGenie]
synonym: "negative regulation of telomerase catalytic core complex formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of TERT-TERC complex assembly" RELATED [GOC:TermGenie]
synonym: "negative regulation of TERT-TERC complex formation" RELATED [GOC:TermGenie]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1904882 ! regulation of telomerase catalytic core complex assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1904868 ! telomerase catalytic core complex assembly
relationship: negatively_regulates GO:1904868 ! telomerase catalytic core complex assembly
created_by: rph
creation_date: 2016-01-05T10:36:09Z

[Term]
id: GO:1904884
name: positive regulation of telomerase catalytic core complex assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of telomerase catalytic core complex assembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26586433]
synonym: "activation of telomerase catalytic core complex assembly" NARROW [GOC:TermGenie]
synonym: "activation of telomerase catalytic core complex formation" NARROW [GOC:TermGenie]
synonym: "activation of TERT-TERC complex assembly" RELATED [GOC:TermGenie]
synonym: "activation of TERT-TERC complex formation" RELATED [GOC:TermGenie]
synonym: "positive regulation of telomerase catalytic core complex formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of TERT-TERC complex assembly" RELATED [GOC:TermGenie]
synonym: "positive regulation of TERT-TERC complex formation" RELATED [GOC:TermGenie]
synonym: "up regulation of telomerase catalytic core complex assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of telomerase catalytic core complex formation" EXACT [GOC:TermGenie]
synonym: "up regulation of TERT-TERC complex assembly" RELATED [GOC:TermGenie]
synonym: "up regulation of TERT-TERC complex formation" RELATED [GOC:TermGenie]
synonym: "up-regulation of telomerase catalytic core complex assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of telomerase catalytic core complex formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of TERT-TERC complex assembly" RELATED [GOC:TermGenie]
synonym: "up-regulation of TERT-TERC complex formation" RELATED [GOC:TermGenie]
synonym: "upregulation of telomerase catalytic core complex assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of telomerase catalytic core complex formation" EXACT [GOC:TermGenie]
synonym: "upregulation of TERT-TERC complex assembly" RELATED [GOC:TermGenie]
synonym: "upregulation of TERT-TERC complex formation" RELATED [GOC:TermGenie]
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1904882 ! regulation of telomerase catalytic core complex assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1904868 ! telomerase catalytic core complex assembly
relationship: positively_regulates GO:1904868 ! telomerase catalytic core complex assembly
created_by: rph
creation_date: 2016-01-05T10:36:16Z

[Term]
id: GO:1904885
name: beta-catenin destruction complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a beta-catenin destruction complex." [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:17143292, PMID:23169527]
synonym: "23S APC complex assembly" NARROW [GOC:TermGenie]
synonym: "23S APC complex formation" NARROW [GOC:TermGenie]
synonym: "APC-Axin-1-beta-catenin complex assembly" EXACT [GOC:TermGenie]
synonym: "APC-Axin-1-beta-catenin complex formation" EXACT [GOC:TermGenie]
synonym: "Axin-APC-beta-catenin-GSK3B complex assembly" EXACT [GOC:TermGenie]
synonym: "Axin-APC-beta-catenin-GSK3B complex formation" EXACT [GOC:TermGenie]
synonym: "BDC assembly" EXACT [GOC:TermGenie]
synonym: "BDC formation" EXACT [GOC:TermGenie]
synonym: "beta-catenin degradation complex assembly" EXACT [GOC:TermGenie]
synonym: "beta-catenin degradation complex formation" EXACT [GOC:TermGenie]
synonym: "beta-catenin destruction complex formation" EXACT [GOC:TermGenie]
synonym: "destruction complex formation" RELATED [PMID:23169527]
is_a: GO:0006461 ! protein complex assembly
created_by: bf
creation_date: 2016-01-05T11:40:55Z

[Term]
id: GO:1904886
name: beta-catenin destruction complex disassembly
namespace: biological_process
def: "The disaggregation of a beta-catenin destruction complex into its constituent components." [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23169527]
synonym: "23S APC complex disassembly" NARROW [GOC:TermGenie]
synonym: "APC-Axin-1-beta-catenin complex disassembly" EXACT [GOC:TermGenie]
synonym: "Axin-APC-beta-catenin-GSK3B complex disassembly" EXACT [GOC:TermGenie]
synonym: "BDC disassembly" EXACT [GOC:TermGenie]
synonym: "beta-catenin degradation complex disassembly" EXACT [GOC:TermGenie]
synonym: "dissociation of beta-catenin degradation complex" EXACT [GOC:bf, PMID:17318175]
is_a: GO:0043241 ! protein complex disassembly
relationship: part_of GO:0060070 ! canonical Wnt signaling pathway
created_by: bf
creation_date: 2016-01-05T11:41:02Z

[Term]
id: GO:1904887
name: Wnt signalosome assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a Wnt signalosome." [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22899650]
synonym: "LRP5/6 signalosome assembly" EXACT [GOC:TermGenie]
synonym: "LRP5/6 signalosome formation" EXACT [GOC:TermGenie]
synonym: "LRP6 signalosome assembly" NARROW [GOC:TermGenie]
synonym: "LRP6 signalosome formation" NARROW [GOC:TermGenie]
synonym: "Wnt signalosome complex assembly" EXACT [GOC:TermGenie]
synonym: "Wnt signalosome complex formation" EXACT [GOC:TermGenie]
synonym: "Wnt signalosome formation" EXACT [GOC:TermGenie]
synonym: "Wnt-LRP5/6 signalosome assembly" EXACT [GOC:TermGenie]
synonym: "Wnt-LRP5/6 signalosome formation" EXACT [GOC:TermGenie]
is_a: GO:0006461 ! protein complex assembly
created_by: bf
creation_date: 2016-01-05T15:34:36Z

[Term]
id: GO:1904888
name: cranial skeletal system development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cranial skeletal system over time, from its formation to the mature structure. The cranial skeletal system is the skeletal subdivision of the head, and includes the skull (cranium plus mandible), pharyngeal and/or hyoid apparatus." [GO_REF:0000094, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11262227]
synonym: "cranial skeleton development" NARROW [GOC:TermGenie]
synonym: "craniofacial development" NARROW [PMID:11262227]
synonym: "cranium development" RELATED [GOC:TermGenie]
synonym: "osteocranium development" NARROW [GOC:TermGenie]
is_a: GO:0048856 ! anatomical structure development
created_by: bf
creation_date: 2016-01-07T13:45:06Z

[Term]
id: GO:1904889
name: regulation of excitatory synapse assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of excitatory synapse assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "regulation of excitatory synapse formation" EXACT [GOC:TermGenie]
is_a: GO:0051963 ! regulation of synapse assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1904861 ! excitatory synapse assembly
relationship: regulates GO:1904861 ! excitatory synapse assembly
created_by: bf
creation_date: 2016-01-07T14:35:53Z

[Term]
id: GO:1904890
name: negative regulation of excitatory synapse assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of excitatory synapse assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "down regulation of excitatory synapse assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of excitatory synapse formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of excitatory synapse assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of excitatory synapse formation" EXACT [GOC:TermGenie]
synonym: "downregulation of excitatory synapse assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of excitatory synapse formation" EXACT [GOC:TermGenie]
synonym: "inhibition of excitatory synapse assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of excitatory synapse formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of excitatory synapse formation" EXACT [GOC:TermGenie]
is_a: GO:0051964 ! negative regulation of synapse assembly
is_a: GO:1904889 ! regulation of excitatory synapse assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1904861 ! excitatory synapse assembly
relationship: negatively_regulates GO:1904861 ! excitatory synapse assembly
created_by: bf
creation_date: 2016-01-07T14:36:00Z

[Term]
id: GO:1904891
name: positive regulation of excitatory synapse assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of excitatory synapse assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21670302]
synonym: "activation of excitatory synapse assembly" NARROW [GOC:TermGenie]
synonym: "activation of excitatory synapse formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of excitatory synapse formation" EXACT [GOC:TermGenie]
synonym: "up regulation of excitatory synapse assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of excitatory synapse formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of excitatory synapse assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of excitatory synapse formation" EXACT [GOC:TermGenie]
synonym: "upregulation of excitatory synapse assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of excitatory synapse formation" EXACT [GOC:TermGenie]
is_a: GO:0051965 ! positive regulation of synapse assembly
is_a: GO:1904889 ! regulation of excitatory synapse assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1904861 ! excitatory synapse assembly
relationship: positively_regulates GO:1904861 ! excitatory synapse assembly
created_by: bf
creation_date: 2016-01-07T14:36:07Z

[Term]
id: GO:1904892
name: regulation of STAT cascade
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of STAT cascade." [GO_REF:0000058, GOC:rjd, GOC:TermGenie, PMID:24587195]
synonym: "regulation of kinase activated-STAT cascade" EXACT [GOC:TermGenie]
synonym: "regulation of kinase-STAT cascade" EXACT [GOC:TermGenie]
synonym: "regulation of STAT signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:1902531 ! regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097696 ! STAT cascade
relationship: regulates GO:0097696 ! STAT cascade
created_by: pr
creation_date: 2016-01-08T08:14:33Z

[Term]
id: GO:1904893
name: negative regulation of STAT cascade
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of STAT cascade." [GO_REF:0000058, GOC:rjd, GOC:TermGenie, PMID:24587195]
synonym: "down regulation of kinase activated-STAT cascade" EXACT [GOC:TermGenie]
synonym: "down regulation of kinase-STAT cascade" EXACT [GOC:TermGenie]
synonym: "down regulation of STAT cascade" EXACT [GOC:TermGenie]
synonym: "down regulation of STAT signalling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of kinase activated-STAT cascade" EXACT [GOC:TermGenie]
synonym: "down-regulation of kinase-STAT cascade" EXACT [GOC:TermGenie]
synonym: "down-regulation of STAT cascade" EXACT [GOC:TermGenie]
synonym: "down-regulation of STAT signalling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of kinase activated-STAT cascade" EXACT [GOC:TermGenie]
synonym: "downregulation of kinase-STAT cascade" EXACT [GOC:TermGenie]
synonym: "downregulation of STAT cascade" EXACT [GOC:TermGenie]
synonym: "downregulation of STAT signalling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of kinase activated-STAT cascade" NARROW [GOC:TermGenie]
synonym: "inhibition of kinase-STAT cascade" NARROW [GOC:TermGenie]
synonym: "inhibition of STAT cascade" NARROW [GOC:TermGenie]
synonym: "inhibition of STAT signalling pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of kinase activated-STAT cascade" EXACT [GOC:TermGenie]
synonym: "negative regulation of kinase-STAT cascade" EXACT [GOC:TermGenie]
synonym: "negative regulation of STAT signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:1902532 ! negative regulation of intracellular signal transduction
is_a: GO:1904892 ! regulation of STAT cascade
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097696 ! STAT cascade
relationship: negatively_regulates GO:0097696 ! STAT cascade
created_by: pr
creation_date: 2016-01-08T08:14:41Z

[Term]
id: GO:1904894
name: positive regulation of STAT cascade
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of STAT cascade." [GO_REF:0000058, GOC:rjd, GOC:TermGenie, PMID:24587195]
synonym: "activation of kinase activated-STAT cascade" NARROW [GOC:TermGenie]
synonym: "activation of kinase-STAT cascade" NARROW [GOC:TermGenie]
synonym: "activation of STAT cascade" NARROW [GOC:TermGenie]
synonym: "activation of STAT signalling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of kinase activated-STAT cascade" EXACT [GOC:TermGenie]
synonym: "positive regulation of kinase-STAT cascade" EXACT [GOC:TermGenie]
synonym: "positive regulation of STAT signalling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of kinase activated-STAT cascade" EXACT [GOC:TermGenie]
synonym: "up regulation of kinase-STAT cascade" EXACT [GOC:TermGenie]
synonym: "up regulation of STAT cascade" EXACT [GOC:TermGenie]
synonym: "up regulation of STAT signalling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of kinase activated-STAT cascade" EXACT [GOC:TermGenie]
synonym: "up-regulation of kinase-STAT cascade" EXACT [GOC:TermGenie]
synonym: "up-regulation of STAT cascade" EXACT [GOC:TermGenie]
synonym: "up-regulation of STAT signalling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of kinase activated-STAT cascade" EXACT [GOC:TermGenie]
synonym: "upregulation of kinase-STAT cascade" EXACT [GOC:TermGenie]
synonym: "upregulation of STAT cascade" EXACT [GOC:TermGenie]
synonym: "upregulation of STAT signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
is_a: GO:1904892 ! regulation of STAT cascade
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097696 ! STAT cascade
relationship: positively_regulates GO:0097696 ! STAT cascade
created_by: pr
creation_date: 2016-01-08T08:14:48Z

[Term]
id: GO:1904895
name: ESCRT complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an ESCRT complex." [GO_REF:0000079, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:21118109]
synonym: "endosomal sorting complex required for transport assembly" EXACT [GOC:TermGenie]
synonym: "endosomal sorting complex required for transport formation" EXACT [GOC:TermGenie]
synonym: "ESCRT complex formation" EXACT [GOC:TermGenie]
is_a: GO:0006461 ! protein complex assembly
created_by: pad
creation_date: 2016-01-12T10:27:11Z

[Term]
id: GO:1904896
name: ESCRT complex disassembly
namespace: biological_process
def: "The disaggregation of an ESCRT complex into its constituent components." [GO_REF:0000079, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:21118109]
synonym: "endosomal sorting complex required for transport disassembly" EXACT [GOC:TermGenie]
is_a: GO:0043241 ! protein complex disassembly
created_by: pad
creation_date: 2016-01-12T10:27:30Z

[Term]
id: GO:1904897
name: regulation of hepatic stellate cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hepatic stellate cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:15358192]
synonym: "regulation of hepatic perisinusoidal cell proliferation" EXACT [GOC:TermGenie]
synonym: "regulation of Ito cell proliferation" EXACT [GOC:TermGenie]
synonym: "regulation of perisinusoidal cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0048145 ! regulation of fibroblast proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990922 ! hepatic stellate cell proliferation
relationship: regulates GO:1990922 ! hepatic stellate cell proliferation
created_by: sl
creation_date: 2016-01-14T15:56:59Z

[Term]
id: GO:1904898
name: negative regulation of hepatic stellate cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hepatic stellate cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:15358192]
synonym: "down regulation of hepatic perisinusoidal cell proliferation" EXACT [GOC:TermGenie]
synonym: "down regulation of hepatic stellate cell proliferation" EXACT [GOC:TermGenie]
synonym: "down regulation of Ito cell proliferation" EXACT [GOC:TermGenie]
synonym: "down regulation of perisinusoidal cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of hepatic perisinusoidal cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of hepatic stellate cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of Ito cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of perisinusoidal cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of hepatic perisinusoidal cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of hepatic stellate cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of Ito cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of perisinusoidal cell proliferation" EXACT [GOC:TermGenie]
synonym: "inhibition of hepatic perisinusoidal cell proliferation" NARROW [GOC:TermGenie]
synonym: "inhibition of hepatic stellate cell proliferation" NARROW [GOC:TermGenie]
synonym: "inhibition of Ito cell proliferation" NARROW [GOC:TermGenie]
synonym: "inhibition of perisinusoidal cell proliferation" NARROW [GOC:TermGenie]
synonym: "negative regulation of hepatic perisinusoidal cell proliferation" EXACT [GOC:TermGenie]
synonym: "negative regulation of Ito cell proliferation" EXACT [GOC:TermGenie]
synonym: "negative regulation of perisinusoidal cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0048147 ! negative regulation of fibroblast proliferation
is_a: GO:1904897 ! regulation of hepatic stellate cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990922 ! hepatic stellate cell proliferation
relationship: negatively_regulates GO:1990922 ! hepatic stellate cell proliferation
created_by: sl
creation_date: 2016-01-14T15:57:06Z

[Term]
id: GO:1904899
name: positive regulation of hepatic stellate cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hepatic stellate cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:15358192]
synonym: "activation of hepatic perisinusoidal cell proliferation" NARROW [GOC:TermGenie]
synonym: "activation of hepatic stellate cell proliferation" NARROW [GOC:TermGenie]
synonym: "activation of Ito cell proliferation" NARROW [GOC:TermGenie]
synonym: "activation of perisinusoidal cell proliferation" NARROW [GOC:TermGenie]
synonym: "positive regulation of hepatic perisinusoidal cell proliferation" EXACT [GOC:TermGenie]
synonym: "positive regulation of Ito cell proliferation" EXACT [GOC:TermGenie]
synonym: "positive regulation of perisinusoidal cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of hepatic perisinusoidal cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of hepatic stellate cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of Ito cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of perisinusoidal cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of hepatic perisinusoidal cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of hepatic stellate cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of Ito cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of perisinusoidal cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of hepatic perisinusoidal cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of hepatic stellate cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of Ito cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of perisinusoidal cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0048146 ! positive regulation of fibroblast proliferation
is_a: GO:1904897 ! regulation of hepatic stellate cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990922 ! hepatic stellate cell proliferation
relationship: positively_regulates GO:1990922 ! hepatic stellate cell proliferation
created_by: sl
creation_date: 2016-01-14T15:57:13Z

[Term]
id: GO:1904900
name: negative regulation of myosin II filament organization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of myosin II filament organization." [GO_REF:0000058, GOC:TermGenie, PMID:22761445]
synonym: "down regulation of myosin II filament assembly or disassembly" RELATED [GOC:TermGenie]
synonym: "down regulation of myosin II filament organisation" EXACT [GOC:TermGenie]
synonym: "down regulation of myosin II filament organization" EXACT [GOC:TermGenie]
synonym: "down regulation of myosin II polymerization or depolymerization" RELATED [GOC:TermGenie]
synonym: "down-regulation of myosin II filament assembly or disassembly" RELATED [GOC:TermGenie]
synonym: "down-regulation of myosin II filament organisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of myosin II filament organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of myosin II polymerization or depolymerization" RELATED [GOC:TermGenie]
synonym: "downregulation of myosin II filament assembly or disassembly" RELATED [GOC:TermGenie]
synonym: "downregulation of myosin II filament organisation" EXACT [GOC:TermGenie]
synonym: "downregulation of myosin II filament organization" EXACT [GOC:TermGenie]
synonym: "downregulation of myosin II polymerization or depolymerization" RELATED [GOC:TermGenie]
synonym: "inhibition of myosin II filament assembly or disassembly" RELATED [GOC:TermGenie]
synonym: "inhibition of myosin II filament organisation" NARROW [GOC:TermGenie]
synonym: "inhibition of myosin II filament organization" NARROW [GOC:TermGenie]
synonym: "inhibition of myosin II polymerization or depolymerization" RELATED [GOC:TermGenie]
synonym: "negative regulation of myosin II filament assembly or disassembly" RELATED [GOC:TermGenie]
synonym: "negative regulation of myosin II filament organisation" EXACT [GOC:TermGenie]
synonym: "negative regulation of myosin II polymerization or depolymerization" RELATED [GOC:TermGenie]
is_a: GO:0043519 ! regulation of myosin II filament organization
is_a: GO:0051494 ! negative regulation of cytoskeleton organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0031038 ! myosin II filament organization
relationship: negatively_regulates GO:0031038 ! myosin II filament organization
created_by: mec
creation_date: 2016-01-15T09:04:54Z

[Term]
id: GO:1904901
name: positive regulation of myosin II filament organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of myosin II filament organization." [GO_REF:0000058, GOC:TermGenie, PMID:22761445]
synonym: "activation of myosin II filament assembly or disassembly" RELATED [GOC:TermGenie]
synonym: "activation of myosin II filament organisation" NARROW [GOC:TermGenie]
synonym: "activation of myosin II filament organization" NARROW [GOC:TermGenie]
synonym: "activation of myosin II polymerization or depolymerization" RELATED [GOC:TermGenie]
synonym: "positive regulation of myosin II filament assembly or disassembly" RELATED [GOC:TermGenie]
synonym: "positive regulation of myosin II filament organisation" EXACT [GOC:TermGenie]
synonym: "positive regulation of myosin II polymerization or depolymerization" RELATED [GOC:TermGenie]
synonym: "up regulation of myosin II filament assembly or disassembly" RELATED [GOC:TermGenie]
synonym: "up regulation of myosin II filament organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of myosin II filament organization" EXACT [GOC:TermGenie]
synonym: "up regulation of myosin II polymerization or depolymerization" RELATED [GOC:TermGenie]
synonym: "up-regulation of myosin II filament assembly or disassembly" RELATED [GOC:TermGenie]
synonym: "up-regulation of myosin II filament organisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of myosin II filament organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of myosin II polymerization or depolymerization" RELATED [GOC:TermGenie]
synonym: "upregulation of myosin II filament assembly or disassembly" RELATED [GOC:TermGenie]
synonym: "upregulation of myosin II filament organisation" EXACT [GOC:TermGenie]
synonym: "upregulation of myosin II filament organization" EXACT [GOC:TermGenie]
synonym: "upregulation of myosin II polymerization or depolymerization" RELATED [GOC:TermGenie]
is_a: GO:0043519 ! regulation of myosin II filament organization
is_a: GO:0051495 ! positive regulation of cytoskeleton organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0031038 ! myosin II filament organization
relationship: positively_regulates GO:0031038 ! myosin II filament organization
created_by: mec
creation_date: 2016-01-15T09:05:02Z

[Term]
id: GO:1904902
name: ESCRT III complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an ESCRT III complex." [GO_REF:0000079, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20588296]
synonym: "ESCRT III complex formation" EXACT [GOC:TermGenie]
is_a: GO:1904895 ! ESCRT complex assembly
created_by: pad
creation_date: 2016-01-18T13:38:07Z

[Term]
id: GO:1904903
name: ESCRT III complex disassembly
namespace: biological_process
def: "The disaggregation of an ESCRT III complex into its constituent components." [GO_REF:0000079, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20588296]
is_a: GO:1904896 ! ESCRT complex disassembly
created_by: pad
creation_date: 2016-01-18T13:38:14Z

[Term]
id: GO:1904904
name: regulation of endothelial cell-matrix adhesion via fibronectin
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endothelial cell-matrix adhesion via fibronectin." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:19460962]
comment: In paper PMID:19460962, in Figure 1D, endothelial cell binding to fibronectin is decreased, as a result of overexpression of miR-92a (URS00003768C5_9606).
is_a: GO:0001952 ! regulation of cell-matrix adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0090674 ! endothelial cell-matrix adhesion via fibronectin
relationship: regulates GO:0090674 ! endothelial cell-matrix adhesion via fibronectin
created_by: bc
creation_date: 2016-01-19T10:23:01Z

[Term]
id: GO:1904905
name: negative regulation of endothelial cell-matrix adhesion via fibronectin
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell-matrix adhesion via fibronectin." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:19460962]
comment: In paper PMID:19460962, in Figure 1D, endothelial cell binding to fibronectin is decreased, as a result of overexpression of miR-92a (URS00003768C5_9606).
synonym: "down regulation of endothelial cell-matrix adhesion via fibronectin" EXACT [GOC:TermGenie]
synonym: "down-regulation of endothelial cell-matrix adhesion via fibronectin" EXACT [GOC:TermGenie]
synonym: "downregulation of endothelial cell-matrix adhesion via fibronectin" EXACT [GOC:TermGenie]
synonym: "inhibition of endothelial cell-matrix adhesion via fibronectin" NARROW [GOC:TermGenie]
is_a: GO:0001953 ! negative regulation of cell-matrix adhesion
is_a: GO:1904904 ! regulation of endothelial cell-matrix adhesion via fibronectin
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0090674 ! endothelial cell-matrix adhesion via fibronectin
relationship: negatively_regulates GO:0090674 ! endothelial cell-matrix adhesion via fibronectin
created_by: bc
creation_date: 2016-01-19T10:23:09Z

[Term]
id: GO:1904906
name: positive regulation of endothelial cell-matrix adhesion via fibronectin
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endothelial cell-matrix adhesion via fibronectin." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:19460962]
comment: In paper PMID:19460962, in Figure 1D, endothelial cell binding to fibronectin is decreased, as a result of overexpression of miR-92a (URS00003768C5_9606).
synonym: "activation of endothelial cell-matrix adhesion via fibronectin" NARROW [GOC:TermGenie]
synonym: "up regulation of endothelial cell-matrix adhesion via fibronectin" EXACT [GOC:TermGenie]
synonym: "up-regulation of endothelial cell-matrix adhesion via fibronectin" EXACT [GOC:TermGenie]
synonym: "upregulation of endothelial cell-matrix adhesion via fibronectin" EXACT [GOC:TermGenie]
is_a: GO:0001954 ! positive regulation of cell-matrix adhesion
is_a: GO:1904904 ! regulation of endothelial cell-matrix adhesion via fibronectin
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0090674 ! endothelial cell-matrix adhesion via fibronectin
relationship: positively_regulates GO:0090674 ! endothelial cell-matrix adhesion via fibronectin
created_by: bc
creation_date: 2016-01-19T10:23:16Z

[Term]
id: GO:1904907
name: regulation of maintenance of mitotic sister chromatid cohesion, telomeric
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion, telomeric." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26373281]
synonym: "regulation of maintenance of mitotic sister chromatin cohesion at telomere" EXACT [GOC:TermGenie]
synonym: "regulation of maintenance of sister chromatin cohesion at telomere at mitosis" EXACT [GOC:TermGenie]
synonym: "regulation of maintenance of telomeric mitotic sister chromatin cohesion" EXACT [GOC:TermGenie]
is_a: GO:0034182 ! regulation of maintenance of mitotic sister chromatid cohesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0099403 ! maintenance of mitotic sister chromatid cohesion, telomeric
relationship: regulates GO:0099403 ! maintenance of mitotic sister chromatid cohesion, telomeric
created_by: rph
creation_date: 2016-01-19T10:30:29Z

[Term]
id: GO:1904908
name: negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion, telomeric." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26373281]
synonym: "down regulation of maintenance of mitotic sister chromatid cohesion, telomeric" EXACT [GOC:TermGenie]
synonym: "down regulation of maintenance of mitotic sister chromatin cohesion at telomere" EXACT [GOC:TermGenie]
synonym: "down regulation of maintenance of sister chromatin cohesion at telomere at mitosis" EXACT [GOC:TermGenie]
synonym: "down regulation of maintenance of telomeric mitotic sister chromatin cohesion" EXACT [GOC:TermGenie]
synonym: "down-regulation of maintenance of mitotic sister chromatid cohesion, telomeric" EXACT [GOC:TermGenie]
synonym: "down-regulation of maintenance of mitotic sister chromatin cohesion at telomere" EXACT [GOC:TermGenie]
synonym: "down-regulation of maintenance of sister chromatin cohesion at telomere at mitosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of maintenance of telomeric mitotic sister chromatin cohesion" EXACT [GOC:TermGenie]
synonym: "downregulation of maintenance of mitotic sister chromatid cohesion, telomeric" EXACT [GOC:TermGenie]
synonym: "downregulation of maintenance of mitotic sister chromatin cohesion at telomere" EXACT [GOC:TermGenie]
synonym: "downregulation of maintenance of sister chromatin cohesion at telomere at mitosis" EXACT [GOC:TermGenie]
synonym: "downregulation of maintenance of telomeric mitotic sister chromatin cohesion" EXACT [GOC:TermGenie]
synonym: "inhibition of maintenance of mitotic sister chromatid cohesion, telomeric" NARROW [GOC:TermGenie]
synonym: "inhibition of maintenance of mitotic sister chromatin cohesion at telomere" NARROW [GOC:TermGenie]
synonym: "inhibition of maintenance of sister chromatin cohesion at telomere at mitosis" NARROW [GOC:TermGenie]
synonym: "inhibition of maintenance of telomeric mitotic sister chromatin cohesion" NARROW [GOC:TermGenie]
synonym: "negative regulation of maintenance of mitotic sister chromatin cohesion at telomere" EXACT [GOC:TermGenie]
synonym: "negative regulation of maintenance of sister chromatin cohesion at telomere at mitosis" EXACT [GOC:TermGenie]
synonym: "negative regulation of maintenance of telomeric mitotic sister chromatin cohesion" EXACT [GOC:TermGenie]
is_a: GO:0034183 ! negative regulation of maintenance of mitotic sister chromatid cohesion
is_a: GO:1904907 ! regulation of maintenance of mitotic sister chromatid cohesion, telomeric
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0099403 ! maintenance of mitotic sister chromatid cohesion, telomeric
relationship: negatively_regulates GO:0099403 ! maintenance of mitotic sister chromatid cohesion, telomeric
created_by: rph
creation_date: 2016-01-19T10:30:36Z

[Term]
id: GO:1904909
name: positive regulation of maintenance of mitotic sister chromatid cohesion, telomeric
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion, telomeric." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26373281]
synonym: "activation of maintenance of mitotic sister chromatid cohesion, telomeric" NARROW [GOC:TermGenie]
synonym: "activation of maintenance of mitotic sister chromatin cohesion at telomere" NARROW [GOC:TermGenie]
synonym: "activation of maintenance of sister chromatin cohesion at telomere at mitosis" NARROW [GOC:TermGenie]
synonym: "activation of maintenance of telomeric mitotic sister chromatin cohesion" NARROW [GOC:TermGenie]
synonym: "positive regulation of maintenance of mitotic sister chromatin cohesion at telomere" EXACT [GOC:TermGenie]
synonym: "positive regulation of maintenance of sister chromatin cohesion at telomere at mitosis" EXACT [GOC:TermGenie]
synonym: "positive regulation of maintenance of telomeric mitotic sister chromatin cohesion" EXACT [GOC:TermGenie]
synonym: "up regulation of maintenance of mitotic sister chromatid cohesion, telomeric" EXACT [GOC:TermGenie]
synonym: "up regulation of maintenance of mitotic sister chromatin cohesion at telomere" EXACT [GOC:TermGenie]
synonym: "up regulation of maintenance of sister chromatin cohesion at telomere at mitosis" EXACT [GOC:TermGenie]
synonym: "up regulation of maintenance of telomeric mitotic sister chromatin cohesion" EXACT [GOC:TermGenie]
synonym: "up-regulation of maintenance of mitotic sister chromatid cohesion, telomeric" EXACT [GOC:TermGenie]
synonym: "up-regulation of maintenance of mitotic sister chromatin cohesion at telomere" EXACT [GOC:TermGenie]
synonym: "up-regulation of maintenance of sister chromatin cohesion at telomere at mitosis" EXACT [GOC:TermGenie]
synonym: "up-regulation of maintenance of telomeric mitotic sister chromatin cohesion" EXACT [GOC:TermGenie]
synonym: "upregulation of maintenance of mitotic sister chromatid cohesion, telomeric" EXACT [GOC:TermGenie]
synonym: "upregulation of maintenance of mitotic sister chromatin cohesion at telomere" EXACT [GOC:TermGenie]
synonym: "upregulation of maintenance of sister chromatin cohesion at telomere at mitosis" EXACT [GOC:TermGenie]
synonym: "upregulation of maintenance of telomeric mitotic sister chromatin cohesion" EXACT [GOC:TermGenie]
is_a: GO:0034184 ! positive regulation of maintenance of mitotic sister chromatid cohesion
is_a: GO:1904907 ! regulation of maintenance of mitotic sister chromatid cohesion, telomeric
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0099403 ! maintenance of mitotic sister chromatid cohesion, telomeric
relationship: positively_regulates GO:0099403 ! maintenance of mitotic sister chromatid cohesion, telomeric
created_by: rph
creation_date: 2016-01-19T10:30:43Z

[Term]
id: GO:1904910
name: regulation of establishment of RNA localization to telomere
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of establishment of RNA localization to telomere." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26586433]
synonym: "regulation of establishment of RNA localisation to telomere" EXACT [GOC:TermGenie]
is_a: GO:0032879 ! regulation of localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097694 ! establishment of RNA localization to telomere
relationship: regulates GO:0097694 ! establishment of RNA localization to telomere
created_by: rph
creation_date: 2016-01-19T10:34:21Z

[Term]
id: GO:1904911
name: negative regulation of establishment of RNA localization to telomere
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of RNA localization to telomere." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26586433]
synonym: "down regulation of establishment of RNA localisation to telomere" EXACT [GOC:TermGenie]
synonym: "down regulation of establishment of RNA localization to telomere" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of RNA localisation to telomere" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of RNA localization to telomere" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of RNA localisation to telomere" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of RNA localization to telomere" EXACT [GOC:TermGenie]
synonym: "inhibition of establishment of RNA localisation to telomere" NARROW [GOC:TermGenie]
synonym: "inhibition of establishment of RNA localization to telomere" NARROW [GOC:TermGenie]
synonym: "negative regulation of establishment of RNA localisation to telomere" EXACT [GOC:TermGenie]
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:1904910 ! regulation of establishment of RNA localization to telomere
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097694 ! establishment of RNA localization to telomere
relationship: negatively_regulates GO:0097694 ! establishment of RNA localization to telomere
created_by: rph
creation_date: 2016-01-19T10:34:28Z

[Term]
id: GO:1904912
name: positive regulation of establishment of RNA localization to telomere
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment of RNA localization to telomere." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26586433]
synonym: "activation of establishment of RNA localisation to telomere" NARROW [GOC:TermGenie]
synonym: "activation of establishment of RNA localization to telomere" NARROW [GOC:TermGenie]
synonym: "positive regulation of establishment of RNA localisation to telomere" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of RNA localisation to telomere" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of RNA localization to telomere" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of RNA localisation to telomere" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of RNA localization to telomere" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of RNA localisation to telomere" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of RNA localization to telomere" EXACT [GOC:TermGenie]
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:1904910 ! regulation of establishment of RNA localization to telomere
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097694 ! establishment of RNA localization to telomere
relationship: positively_regulates GO:0097694 ! establishment of RNA localization to telomere
created_by: rph
creation_date: 2016-01-19T10:34:35Z

[Term]
id: GO:1904913
name: regulation of establishment of macromolecular complex localization to telomere
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of establishment of macromolecular complex localization to telomere." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26586433]
synonym: "regulation of establishment of macromolecular complex localisation to telomere" EXACT [GOC:TermGenie]
is_a: GO:0060341 ! regulation of cellular localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097695 ! establishment of macromolecular complex localization to telomere
relationship: regulates GO:0097695 ! establishment of macromolecular complex localization to telomere
created_by: rph
creation_date: 2016-01-19T10:38:22Z

[Term]
id: GO:1904914
name: negative regulation of establishment of macromolecular complex localization to telomere
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of macromolecular complex localization to telomere." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26586433]
synonym: "down regulation of establishment of macromolecular complex localisation to telomere" EXACT [GOC:TermGenie]
synonym: "down regulation of establishment of macromolecular complex localization to telomere" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of macromolecular complex localisation to telomere" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of macromolecular complex localization to telomere" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of macromolecular complex localisation to telomere" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of macromolecular complex localization to telomere" EXACT [GOC:TermGenie]
synonym: "inhibition of establishment of macromolecular complex localisation to telomere" NARROW [GOC:TermGenie]
synonym: "inhibition of establishment of macromolecular complex localization to telomere" NARROW [GOC:TermGenie]
synonym: "negative regulation of establishment of macromolecular complex localisation to telomere" EXACT [GOC:TermGenie]
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:1904913 ! regulation of establishment of macromolecular complex localization to telomere
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097695 ! establishment of macromolecular complex localization to telomere
relationship: negatively_regulates GO:0097695 ! establishment of macromolecular complex localization to telomere
created_by: rph
creation_date: 2016-01-19T10:38:29Z

[Term]
id: GO:1904915
name: positive regulation of establishment of macromolecular complex localization to telomere
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment of macromolecular complex localization to telomere." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26586433]
synonym: "activation of establishment of macromolecular complex localisation to telomere" NARROW [GOC:TermGenie]
synonym: "activation of establishment of macromolecular complex localization to telomere" NARROW [GOC:TermGenie]
synonym: "positive regulation of establishment of macromolecular complex localisation to telomere" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of macromolecular complex localisation to telomere" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of macromolecular complex localization to telomere" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of macromolecular complex localisation to telomere" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of macromolecular complex localization to telomere" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of macromolecular complex localisation to telomere" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of macromolecular complex localization to telomere" EXACT [GOC:TermGenie]
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:1904913 ! regulation of establishment of macromolecular complex localization to telomere
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097695 ! establishment of macromolecular complex localization to telomere
relationship: positively_regulates GO:0097695 ! establishment of macromolecular complex localization to telomere
created_by: rph
creation_date: 2016-01-19T10:38:36Z

[Term]
id: GO:1904916
name: transmembrane L-lysine transport from lysosomal lumen to cytosol
namespace: biological_process
def: "The directed movement of L-lysine across a membrane from lysosomal lumen to cytosol." [GO_REF:0000078, GOC:kmv, GOC:TermGenie, PMID:22822152]
is_a: GO:0007041 ! lysosomal transport
is_a: GO:1903401 ! L-lysine transmembrane transport
created_by: kmv
creation_date: 2016-01-21T16:27:41Z

[Term]
id: GO:1904917
name: transmembrane L-arginine transport from lysosomal lumen to cytosol
namespace: biological_process
def: "The directed movement of L-arginine across a membrane from lysosomal lumen to cytosol." [GO_REF:0000078, GOC:kmv, GOC:TermGenie, PMID:22822152]
is_a: GO:0007041 ! lysosomal transport
is_a: GO:1903400 ! L-arginine transmembrane transport
created_by: kmv
creation_date: 2016-01-21T16:27:48Z

[Term]
id: GO:1904918
name: transmembrane L-histidine transport from lysosomal lumen to cytosol
namespace: biological_process
def: "The directed movement of L-histidine across a membrane from lysosomal lumen to cytosol." [GO_REF:0000078, GOC:kmv, GOC:TermGenie, PMID:22822152]
is_a: GO:0007041 ! lysosomal transport
is_a: GO:0089709 ! L-histidine transmembrane transport
created_by: kmv
creation_date: 2016-01-21T16:27:55Z

[Term]
id: GO:1904919
name: transmembrane L-cystine transport from lysosomal lumen to cytosol
namespace: biological_process
def: "The directed movement of L-cystine across a membrane from lysosomal lumen to cytosol." [GO_REF:0000078, GOC:kmv, GOC:TermGenie, PMID:22822152]
is_a: GO:0007041 ! lysosomal transport
is_a: GO:0015811 ! L-cystine transport
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport
created_by: kmv
creation_date: 2016-01-21T16:28:02Z

[Term]
id: GO:1904920
name: regulation of MAPK cascade involved in axon regeneration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of MAPK cascade involved in axon regeneration." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:20203177]
synonym: "regulation of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "regulation of MAP kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "regulation of MAP kinase kinase kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "regulation of MAPK signal transduction involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "regulation of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie]
synonym: "regulation of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie]
synonym: "regulation of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "regulation of MAPKKK cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "regulation of mitogen-activated protein kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
is_a: GO:0043408 ! regulation of MAPK cascade
is_a: GO:0048679 ! regulation of axon regeneration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1903616 ! MAPK cascade involved in axon regeneration
relationship: regulates GO:1903616 ! MAPK cascade involved in axon regeneration
created_by: kmv
creation_date: 2016-01-25T17:03:35Z

[Term]
id: GO:1904921
name: negative regulation of MAPK cascade involved in axon regeneration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of MAPK cascade involved in axon regeneration." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:20203177]
synonym: "down regulation of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "down regulation of MAP kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "down regulation of MAP kinase kinase kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "down regulation of MAPK cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "down regulation of MAPK signal transduction involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "down regulation of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie]
synonym: "down regulation of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie]
synonym: "down regulation of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "down regulation of MAPKKK cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "down regulation of mitogen-activated protein kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "down-regulation of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "down-regulation of MAP kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "down-regulation of MAP kinase kinase kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "down-regulation of MAPK cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "down-regulation of MAPK signal transduction involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "down-regulation of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie]
synonym: "down-regulation of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie]
synonym: "down-regulation of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "down-regulation of MAPKKK cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitogen-activated protein kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "downregulation of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "downregulation of MAP kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "downregulation of MAP kinase kinase kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "downregulation of MAPK cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "downregulation of MAPK signal transduction involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "downregulation of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie]
synonym: "downregulation of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie]
synonym: "downregulation of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "downregulation of MAPKKK cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "downregulation of mitogen-activated protein kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "inhibition of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "inhibition of MAP kinase cascade involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "inhibition of MAP kinase kinase kinase cascade involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "inhibition of MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "inhibition of MAPK signal transduction involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "inhibition of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie]
synonym: "inhibition of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie]
synonym: "inhibition of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "inhibition of MAPKKK cascade involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "inhibition of mitogen-activated protein kinase cascade involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "negative regulation of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "negative regulation of MAP kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "negative regulation of MAP kinase kinase kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "negative regulation of MAPK signal transduction involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "negative regulation of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie]
synonym: "negative regulation of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie]
synonym: "negative regulation of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "negative regulation of MAPKKK cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "negative regulation of mitogen-activated protein kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
is_a: GO:0043409 ! negative regulation of MAPK cascade
is_a: GO:0048681 ! negative regulation of axon regeneration
is_a: GO:1904920 ! regulation of MAPK cascade involved in axon regeneration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1903616 ! MAPK cascade involved in axon regeneration
relationship: negatively_regulates GO:1903616 ! MAPK cascade involved in axon regeneration
created_by: kmv
creation_date: 2016-01-25T17:03:42Z

[Term]
id: GO:1904922
name: positive regulation of MAPK cascade involved in axon regeneration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of MAPK cascade involved in axon regeneration." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:20203177]
synonym: "activation of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "activation of MAP kinase cascade involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "activation of MAP kinase kinase kinase cascade involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "activation of MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "activation of MAPK signal transduction involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "activation of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie]
synonym: "activation of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie]
synonym: "activation of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "activation of MAPKKK cascade involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "activation of mitogen-activated protein kinase cascade involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "positive regulation of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "positive regulation of MAP kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "positive regulation of MAP kinase kinase kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "positive regulation of MAPK signal transduction involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "positive regulation of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie]
synonym: "positive regulation of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie]
synonym: "positive regulation of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "positive regulation of MAPKKK cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "positive regulation of mitogen-activated protein kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "up regulation of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "up regulation of MAP kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "up regulation of MAP kinase kinase kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "up regulation of MAPK cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "up regulation of MAPK signal transduction involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "up regulation of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie]
synonym: "up regulation of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie]
synonym: "up regulation of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "up regulation of MAPKKK cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "up regulation of mitogen-activated protein kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "up-regulation of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "up-regulation of MAP kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "up-regulation of MAP kinase kinase kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "up-regulation of MAPK cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "up-regulation of MAPK signal transduction involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "up-regulation of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie]
synonym: "up-regulation of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie]
synonym: "up-regulation of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "up-regulation of MAPKKK cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitogen-activated protein kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "upregulation of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "upregulation of MAP kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "upregulation of MAP kinase kinase kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "upregulation of MAPK cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "upregulation of MAPK signal transduction involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "upregulation of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie]
synonym: "upregulation of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie]
synonym: "upregulation of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "upregulation of MAPKKK cascade involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "upregulation of mitogen-activated protein kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie]
is_a: GO:0043410 ! positive regulation of MAPK cascade
is_a: GO:0048680 ! positive regulation of axon regeneration
is_a: GO:1904920 ! regulation of MAPK cascade involved in axon regeneration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1903616 ! MAPK cascade involved in axon regeneration
relationship: positively_regulates GO:1903616 ! MAPK cascade involved in axon regeneration
created_by: kmv
creation_date: 2016-01-25T17:03:49Z

[Term]
id: GO:1904923
name: regulation of mitophagy in response to mitochondrial depolarization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitophagy in response to mitochondrial depolarization." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22020285]
is_a: GO:1901524 ! regulation of macromitophagy
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0098779 ! mitophagy in response to mitochondrial depolarization
relationship: regulates GO:0098779 ! mitophagy in response to mitochondrial depolarization
created_by: pad
creation_date: 2016-01-26T11:23:50Z

[Term]
id: GO:1904924
name: negative regulation of mitophagy in response to mitochondrial depolarization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitophagy in response to mitochondrial depolarization." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22020285]
synonym: "down regulation of mitophagy in response to mitochondrial depolarization" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitophagy in response to mitochondrial depolarization" EXACT [GOC:TermGenie]
synonym: "downregulation of mitophagy in response to mitochondrial depolarization" EXACT [GOC:TermGenie]
synonym: "inhibition of mitophagy in response to mitochondrial depolarization" NARROW [GOC:TermGenie]
is_a: GO:1901525 ! negative regulation of macromitophagy
is_a: GO:1904923 ! regulation of mitophagy in response to mitochondrial depolarization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0098779 ! mitophagy in response to mitochondrial depolarization
relationship: negatively_regulates GO:0098779 ! mitophagy in response to mitochondrial depolarization
created_by: pad
creation_date: 2016-01-26T11:23:58Z

[Term]
id: GO:1904925
name: positive regulation of mitophagy in response to mitochondrial depolarization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitophagy in response to mitochondrial depolarization." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22020285]
synonym: "activation of mitophagy in response to mitochondrial depolarization" NARROW [GOC:TermGenie]
synonym: "up regulation of mitophagy in response to mitochondrial depolarization" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitophagy in response to mitochondrial depolarization" EXACT [GOC:TermGenie]
synonym: "upregulation of mitophagy in response to mitochondrial depolarization" EXACT [GOC:TermGenie]
is_a: GO:1901526 ! positive regulation of macromitophagy
is_a: GO:1904923 ! regulation of mitophagy in response to mitochondrial depolarization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0098779 ! mitophagy in response to mitochondrial depolarization
relationship: positively_regulates GO:0098779 ! mitophagy in response to mitochondrial depolarization
created_by: pad
creation_date: 2016-01-26T11:24:05Z

[Term]
id: GO:1904926
name: response to palmitoleic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a palmitoleic acid stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:25429233]
is_a: GO:0070542 ! response to fatty acid
created_by: mr
creation_date: 2016-01-27T23:07:22Z

[Term]
id: GO:1904927
name: cellular response to palmitoleic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a palmitoleic acid stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:25429233]
is_a: GO:0071398 ! cellular response to fatty acid
is_a: GO:1904926 ! response to palmitoleic acid
created_by: mr
creation_date: 2016-01-27T23:07:31Z

[Term]
id: GO:1904928
name: coreceptor activity involved in canonical Wnt signaling pathway
namespace: molecular_function
def: "Any coreceptor activity that is involved in a canonical Wnt signaling pathway." [GO_REF:0000061, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24431302]
synonym: "coreceptor activity involved in canonical Wnt receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "coreceptor activity involved in canonical Wnt-activated signaling pathway" EXACT [GOC:TermGenie]
synonym: "coreceptor activity involved in frizzled-1 receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "coreceptor activity involved in Wnt receptor signaling pathway through beta-catenin" EXACT [GOC:TermGenie]
synonym: "coreceptor activity involved in Wnt receptor signaling pathway via beta-catenin" EXACT [GOC:TermGenie]
synonym: "coreceptor activity involved in Wnt receptor signalling pathway through beta-catenin" EXACT [GOC:TermGenie]
synonym: "coreceptor, insoluble ligand activity involved in canonical Wnt receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor, insoluble ligand activity involved in canonical Wnt signaling pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor, insoluble ligand activity involved in canonical Wnt-activated signaling pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor, insoluble ligand activity involved in frizzled-1 receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor, insoluble ligand activity involved in Wnt receptor signaling pathway through beta-catenin" RELATED [GOC:TermGenie]
synonym: "coreceptor, insoluble ligand activity involved in Wnt receptor signaling pathway via beta-catenin" RELATED [GOC:TermGenie]
synonym: "coreceptor, insoluble ligand activity involved in Wnt receptor signalling pathway through beta-catenin" RELATED [GOC:TermGenie]
synonym: "coreceptor, soluble ligand activity involved in canonical Wnt receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor, soluble ligand activity involved in canonical Wnt signaling pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor, soluble ligand activity involved in canonical Wnt-activated signaling pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor, soluble ligand activity involved in frizzled-1 receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor, soluble ligand activity involved in Wnt receptor signaling pathway through beta-catenin" RELATED [GOC:TermGenie]
synonym: "coreceptor, soluble ligand activity involved in Wnt receptor signaling pathway via beta-catenin" RELATED [GOC:TermGenie]
synonym: "coreceptor, soluble ligand activity involved in Wnt receptor signalling pathway through beta-catenin" RELATED [GOC:TermGenie]
synonym: "Wnt co-receptor activity, canonical signaling" EXACT [GOC:bf]
synonym: "Wnt co-receptor, canonical pathway" EXACT [GOC:bf]
is_a: GO:0071936 ! coreceptor activity involved in Wnt signaling pathway
intersection_of: GO:0015026 ! coreceptor activity
intersection_of: part_of GO:0060070 ! canonical Wnt signaling pathway
relationship: part_of GO:0060070 ! canonical Wnt signaling pathway
created_by: bf
creation_date: 2016-01-28T15:14:46Z

[Term]
id: GO:1904929
name: coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway
namespace: molecular_function
def: "Any coreceptor activity that is involved in Wnt signaling pathway, planar cell polarity pathway." [GO_REF:0000061, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24431302]
synonym: "coreceptor activity involved in non-canonical Wnt signaling pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor activity involved in PCP pathway" EXACT [GOC:TermGenie]
synonym: "coreceptor activity involved in planar cell polarity pathway" EXACT [GOC:TermGenie]
synonym: "coreceptor activity involved in Wnt receptor signaling pathway, planar cell polarity pathway" EXACT [GOC:TermGenie]
synonym: "coreceptor activity involved in Wnt receptor signalling pathway, planar cell polarity pathway" EXACT [GOC:TermGenie]
synonym: "coreceptor activity involved in Wnt-activated signaling pathway, planar cell polarity pathway" EXACT [GOC:TermGenie]
synonym: "coreceptor activity involved in Wnt-JNK signaling pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor activity involved in Wnt-PCP signaling pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor, insoluble ligand activity involved in non-canonical Wnt signaling pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor, insoluble ligand activity involved in PCP pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor, insoluble ligand activity involved in planar cell polarity pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor, insoluble ligand activity involved in Wnt receptor signaling pathway, planar cell polarity pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor, insoluble ligand activity involved in Wnt receptor signalling pathway, planar cell polarity pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor, insoluble ligand activity involved in Wnt signaling pathway, planar cell polarity pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor, insoluble ligand activity involved in Wnt-activated signaling pathway, planar cell polarity pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor, insoluble ligand activity involved in Wnt-JNK signaling pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor, insoluble ligand activity involved in Wnt-PCP signaling pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor, soluble ligand activity involved in non-canonical Wnt signaling pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor, soluble ligand activity involved in PCP pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor, soluble ligand activity involved in planar cell polarity pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor, soluble ligand activity involved in Wnt receptor signaling pathway, planar cell polarity pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor, soluble ligand activity involved in Wnt receptor signalling pathway, planar cell polarity pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor, soluble ligand activity involved in Wnt signaling pathway, planar cell polarity pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor, soluble ligand activity involved in Wnt-activated signaling pathway, planar cell polarity pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor, soluble ligand activity involved in Wnt-JNK signaling pathway" RELATED [GOC:TermGenie]
synonym: "coreceptor, soluble ligand activity involved in Wnt-PCP signaling pathway" RELATED [GOC:TermGenie]
synonym: "Wnt co-receptor activity, non-canonical signaling" BROAD [GOC:bf]
synonym: "Wnt co-receptor, non-canonical pathway" BROAD [GOC:bf]
synonym: "Wnt/PCP co-receptor activity" EXACT [PMID:24431302]
is_a: GO:0071936 ! coreceptor activity involved in Wnt signaling pathway
intersection_of: GO:0015026 ! coreceptor activity
intersection_of: part_of GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway
relationship: part_of GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway
created_by: bf
creation_date: 2016-01-28T15:15:01Z

[Term]
id: GO:1904930
name: amphisome membrane
namespace: cellular_component
def: "Any membrane that is part of an amphisome." [GO_REF:0000064, GOC:bhm, GOC:TermGenie, PMID:17984323]
is_a: GO:0000421 ! autophagosome membrane
relationship: part_of GO:0044753 ! amphisome
created_by: pr
creation_date: 2016-01-29T11:40:13Z

[Term]
id: GO:1904931
name: MCM complex binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an MCM complex." [GO_REF:000102, GOC:TermGenie, PMID:12604790]
synonym: "mini-chromosome maintenance complex binding" EXACT [GOC:TermGenie]
is_a: GO:0032403 ! protein complex binding
created_by: mah
creation_date: 2016-01-29T11:48:10Z

[Term]
id: GO:1904932
name: negative regulation of cartilage condensation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cartilage condensation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17604018]
synonym: "down regulation of cartilage condensation" EXACT [GOC:TermGenie]
synonym: "down-regulation of cartilage condensation" EXACT [GOC:TermGenie]
synonym: "downregulation of cartilage condensation" EXACT [GOC:TermGenie]
synonym: "inhibition of cartilage condensation" NARROW [GOC:TermGenie]
is_a: GO:0061037 ! negative regulation of cartilage development
is_a: GO:1902026 ! regulation of cartilage condensation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001502 ! cartilage condensation
relationship: negatively_regulates GO:0001502 ! cartilage condensation
created_by: mr
creation_date: 2016-01-29T18:13:39Z

[Term]
id: GO:1904933
name: regulation of cell proliferation in midbrain
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell proliferation in midbrain." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18953410, PMID:24431302]
synonym: "regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie]
synonym: "regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie]
is_a: GO:0051960 ! regulation of nervous system development
is_a: GO:2000177 ! regulation of neural precursor cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0033278 ! cell proliferation in midbrain
relationship: regulates GO:0033278 ! cell proliferation in midbrain
created_by: bf
creation_date: 2016-02-01T13:16:11Z

[Term]
id: GO:1904934
name: negative regulation of cell proliferation in midbrain
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation in midbrain." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18953410, PMID:24431302]
synonym: "down regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie]
synonym: "down regulation of cell proliferation in midbrain" EXACT [GOC:TermGenie]
synonym: "down regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie]
synonym: "down-regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell proliferation in midbrain" EXACT [GOC:TermGenie]
synonym: "down-regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie]
synonym: "downregulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie]
synonym: "downregulation of cell proliferation in midbrain" EXACT [GOC:TermGenie]
synonym: "downregulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie]
synonym: "inhibition of cell proliferation in mesencephalon" NARROW [GOC:TermGenie]
synonym: "inhibition of cell proliferation in midbrain" NARROW [GOC:TermGenie]
synonym: "inhibition of mesencepahalic cell proliferation" RELATED [GOC:TermGenie]
synonym: "negative regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie]
synonym: "negative regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie]
is_a: GO:0051961 ! negative regulation of nervous system development
is_a: GO:1904933 ! regulation of cell proliferation in midbrain
is_a: GO:2000178 ! negative regulation of neural precursor cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0033278 ! cell proliferation in midbrain
relationship: negatively_regulates GO:0033278 ! cell proliferation in midbrain
created_by: bf
creation_date: 2016-02-01T13:16:19Z

[Term]
id: GO:1904935
name: positive regulation of cell proliferation in midbrain
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell proliferation in midbrain." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24431302]
synonym: "activation of cell proliferation in mesencephalon" NARROW [GOC:TermGenie]
synonym: "activation of cell proliferation in midbrain" NARROW [GOC:TermGenie]
synonym: "activation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie]
synonym: "positive regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie]
synonym: "positive regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie]
synonym: "up regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie]
synonym: "up regulation of cell proliferation in midbrain" EXACT [GOC:TermGenie]
synonym: "up regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie]
synonym: "up-regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell proliferation in midbrain" EXACT [GOC:TermGenie]
synonym: "up-regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie]
synonym: "upregulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie]
synonym: "upregulation of cell proliferation in midbrain" EXACT [GOC:TermGenie]
synonym: "upregulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie]
is_a: GO:0051962 ! positive regulation of nervous system development
is_a: GO:1904933 ! regulation of cell proliferation in midbrain
is_a: GO:2000179 ! positive regulation of neural precursor cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0033278 ! cell proliferation in midbrain
relationship: positively_regulates GO:0033278 ! cell proliferation in midbrain
created_by: bf
creation_date: 2016-02-01T13:16:27Z

[Term]
id: GO:1904936
name: interneuron migration
namespace: biological_process
def: "The orderly movement of an interneuron from one site to another." [GO_REF:0000091, GOC:ah, GOC:TermGenie, PMID:18622031]
synonym: "inter neuron migration" EXACT [GOC:ah]
synonym: "inter-neuron migration" EXACT [GOC:ah]
is_a: GO:0001764 ! neuron migration
created_by: ah
creation_date: 2016-02-01T14:04:32Z

[Term]
id: GO:1904937
name: sensory neuron migration
namespace: biological_process
def: "The orderly movement of a sensory neuron from one site to another." [GO_REF:0000091, GOC:ah, GOC:TermGenie, PMID:18622031]
is_a: GO:0001764 ! neuron migration
created_by: ah
creation_date: 2016-02-01T14:15:50Z

[Term]
id: GO:1904938
name: planar cell polarity pathway involved in axon guidance
namespace: biological_process
def: "Any Wnt signaling pathway, planar cell polarity pathway that is involved in axon guidance." [GO_REF:0000060, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21106844, PMID:23517308]
synonym: "non-canonical Wnt signaling pathway involved in axon chemotaxis" RELATED [GOC:TermGenie]
synonym: "non-canonical Wnt signaling pathway involved in axon growth cone guidance" RELATED [GOC:TermGenie]
synonym: "non-canonical Wnt signaling pathway involved in axon guidance" RELATED [GOC:TermGenie]
synonym: "non-canonical Wnt signaling pathway involved in axon pathfinding" RELATED [GOC:TermGenie]
synonym: "PCP pathway involved in axon chemotaxis" RELATED [GOC:TermGenie]
synonym: "PCP pathway involved in axon growth cone guidance" NARROW [GOC:TermGenie]
synonym: "PCP pathway involved in axon guidance" EXACT [GOC:TermGenie]
synonym: "PCP pathway involved in axon pathfinding" EXACT [GOC:TermGenie]
synonym: "planar cell polarity pathway involved in axon chemotaxis" RELATED [GOC:TermGenie]
synonym: "planar cell polarity pathway involved in axon growth cone guidance" NARROW [GOC:TermGenie]
synonym: "planar cell polarity pathway involved in axon guidance" EXACT [GOC:TermGenie]
synonym: "planar cell polarity pathway involved in axon pathfinding" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signaling pathway, planar cell polarity pathway involved in axon chemotaxis" RELATED [GOC:TermGenie]
synonym: "Wnt receptor signaling pathway, planar cell polarity pathway involved in axon growth cone guidance" NARROW [GOC:TermGenie]
synonym: "Wnt receptor signaling pathway, planar cell polarity pathway involved in axon guidance" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signaling pathway, planar cell polarity pathway involved in axon pathfinding" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signalling pathway, planar cell polarity pathway involved in axon chemotaxis" RELATED [GOC:TermGenie]
synonym: "Wnt receptor signalling pathway, planar cell polarity pathway involved in axon growth cone guidance" NARROW [GOC:TermGenie]
synonym: "Wnt receptor signalling pathway, planar cell polarity pathway involved in axon guidance" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signalling pathway, planar cell polarity pathway involved in axon pathfinding" EXACT [GOC:TermGenie]
synonym: "Wnt signaling pathway, planar cell polarity pathway involved in axon chemotaxis" RELATED [GOC:TermGenie]
synonym: "Wnt signaling pathway, planar cell polarity pathway involved in axon growth cone guidance" NARROW [GOC:TermGenie]
synonym: "Wnt signaling pathway, planar cell polarity pathway involved in axon guidance" EXACT [GOC:bf]
synonym: "Wnt signaling pathway, planar cell polarity pathway involved in axon pathfinding" EXACT [GOC:TermGenie]
synonym: "Wnt-activated signaling pathway, planar cell polarity pathway involved in axon chemotaxis" RELATED [GOC:TermGenie]
synonym: "Wnt-activated signaling pathway, planar cell polarity pathway involved in axon growth cone guidance" NARROW [GOC:TermGenie]
synonym: "Wnt-activated signaling pathway, planar cell polarity pathway involved in axon guidance" EXACT [GOC:TermGenie]
synonym: "Wnt-activated signaling pathway, planar cell polarity pathway involved in axon pathfinding" EXACT [GOC:TermGenie]
synonym: "Wnt-JNK signaling pathway involved in axon chemotaxis" RELATED [GOC:TermGenie]
synonym: "Wnt-JNK signaling pathway involved in axon growth cone guidance" RELATED [GOC:TermGenie]
synonym: "Wnt-JNK signaling pathway involved in axon guidance" RELATED [GOC:TermGenie]
synonym: "Wnt-JNK signaling pathway involved in axon pathfinding" RELATED [GOC:TermGenie]
synonym: "Wnt-PCP signaling involved in axon guidance" EXACT [GOC:bf]
synonym: "Wnt-PCP signaling pathway involved in axon chemotaxis" RELATED [GOC:TermGenie]
synonym: "Wnt-PCP signaling pathway involved in axon growth cone guidance" RELATED [GOC:TermGenie]
synonym: "Wnt-PCP signaling pathway involved in axon guidance" RELATED [GOC:TermGenie]
synonym: "Wnt-PCP signaling pathway involved in axon pathfinding" RELATED [GOC:TermGenie]
is_a: GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway
intersection_of: GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway
intersection_of: part_of GO:0007411 ! axon guidance
relationship: part_of GO:0007411 ! axon guidance
created_by: bf
creation_date: 2016-02-02T14:46:26Z

[Term]
id: GO:1904939
name: regulation of DNA nucleotidylexotransferase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA nucleotidylexotransferase activity." [GO_REF:0000059, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23575307]
synonym: "regulation of addase activity" EXACT [GOC:TermGenie]
synonym: "regulation of deoxynucleotidyl terminal transferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of deoxyribonucleic acid nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of deoxyribonucleic nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of TdT" RELATED [GOC:TermGenie]
synonym: "regulation of terminal addition enzyme activity" RELATED [GOC:TermGenie]
synonym: "regulation of terminal deoxynucleotide transferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of terminal deoxynucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of terminal deoxyribonucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "regulation of terminal transferase activity" EXACT [GOC:TermGenie]
is_a: GO:0051338 ! regulation of transferase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003912 ! DNA nucleotidylexotransferase activity
relationship: regulates GO:0003912 ! DNA nucleotidylexotransferase activity
created_by: bc
creation_date: 2016-02-02T15:15:57Z

[Term]
id: GO:1904940
name: negative regulation of DNA nucleotidylexotransferase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA nucleotidylexotransferase activity." [GO_REF:0000059, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23575307]
synonym: "down regulation of addase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of deoxynucleotidyl terminal transferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of deoxyribonucleic acid nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of deoxyribonucleic nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of DNA nucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of TdT" RELATED [GOC:TermGenie]
synonym: "down regulation of terminal addition enzyme activity" RELATED [GOC:TermGenie]
synonym: "down regulation of terminal deoxynucleotide transferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of terminal deoxynucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of terminal deoxyribonucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of terminal transferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of addase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of deoxynucleotidyl terminal transferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of deoxyribonucleic acid nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of deoxyribonucleic nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA nucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of TdT" RELATED [GOC:TermGenie]
synonym: "down-regulation of terminal addition enzyme activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of terminal deoxynucleotide transferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of terminal deoxynucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of terminal deoxyribonucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of terminal transferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of addase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of deoxynucleotidyl terminal transferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of deoxyribonucleic acid nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of deoxyribonucleic nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA nucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of TdT" RELATED [GOC:TermGenie]
synonym: "downregulation of terminal addition enzyme activity" RELATED [GOC:TermGenie]
synonym: "downregulation of terminal deoxynucleotide transferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of terminal deoxynucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of terminal deoxyribonucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of terminal transferase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of addase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of deoxynucleotidyl terminal transferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of deoxyribonucleic acid nucleotidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of deoxyribonucleic nucleotidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA nucleotidylexotransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of TdT" RELATED [GOC:TermGenie]
synonym: "inhibition of terminal addition enzyme activity" RELATED [GOC:TermGenie]
synonym: "inhibition of terminal deoxynucleotide transferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of terminal deoxynucleotidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of terminal deoxyribonucleotidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of terminal transferase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of addase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of deoxynucleotidyl terminal transferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of deoxyribonucleic acid nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of deoxyribonucleic nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of TdT" RELATED [GOC:TermGenie]
synonym: "negative regulation of terminal addition enzyme activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of terminal deoxynucleotide transferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of terminal deoxynucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of terminal deoxyribonucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of terminal transferase activity" EXACT [GOC:TermGenie]
is_a: GO:0051348 ! negative regulation of transferase activity
is_a: GO:1904939 ! regulation of DNA nucleotidylexotransferase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003912 ! DNA nucleotidylexotransferase activity
relationship: negatively_regulates GO:0003912 ! DNA nucleotidylexotransferase activity
created_by: bc
creation_date: 2016-02-02T15:16:05Z

[Term]
id: GO:1904941
name: positive regulation of DNA nucleotidylexotransferase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA nucleotidylexotransferase activity." [GO_REF:0000059, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23575307]
synonym: "activation of addase activity" NARROW [GOC:TermGenie]
synonym: "activation of deoxynucleotidyl terminal transferase activity" NARROW [GOC:TermGenie]
synonym: "activation of deoxyribonucleic acid nucleotidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of deoxyribonucleic nucleotidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of DNA nucleotidylexotransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of TdT" RELATED [GOC:TermGenie]
synonym: "activation of terminal addition enzyme activity" RELATED [GOC:TermGenie]
synonym: "activation of terminal deoxynucleotide transferase activity" NARROW [GOC:TermGenie]
synonym: "activation of terminal deoxynucleotidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of terminal deoxyribonucleotidyltransferase activity" NARROW [GOC:TermGenie]
synonym: "activation of terminal transferase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of addase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of deoxynucleotidyl terminal transferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of deoxyribonucleic acid nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of deoxyribonucleic nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of TdT" RELATED [GOC:TermGenie]
synonym: "positive regulation of terminal addition enzyme activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of terminal deoxynucleotide transferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of terminal deoxynucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of terminal deoxyribonucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of terminal transferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of addase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of deoxynucleotidyl terminal transferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of deoxyribonucleic acid nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of deoxyribonucleic nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA nucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of TdT" RELATED [GOC:TermGenie]
synonym: "up regulation of terminal addition enzyme activity" RELATED [GOC:TermGenie]
synonym: "up regulation of terminal deoxynucleotide transferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of terminal deoxynucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of terminal deoxyribonucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of terminal transferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of addase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of deoxynucleotidyl terminal transferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of deoxyribonucleic acid nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of deoxyribonucleic nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA nucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of TdT" RELATED [GOC:TermGenie]
synonym: "up-regulation of terminal addition enzyme activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of terminal deoxynucleotide transferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of terminal deoxynucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of terminal deoxyribonucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of terminal transferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of addase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of deoxynucleotidyl terminal transferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of deoxyribonucleic acid nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of deoxyribonucleic nucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA nucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of TdT" RELATED [GOC:TermGenie]
synonym: "upregulation of terminal addition enzyme activity" RELATED [GOC:TermGenie]
synonym: "upregulation of terminal deoxynucleotide transferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of terminal deoxynucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of terminal deoxyribonucleotidyltransferase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of terminal transferase activity" EXACT [GOC:TermGenie]
is_a: GO:0051347 ! positive regulation of transferase activity
is_a: GO:1904939 ! regulation of DNA nucleotidylexotransferase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003912 ! DNA nucleotidylexotransferase activity
relationship: positively_regulates GO:0003912 ! DNA nucleotidylexotransferase activity
created_by: bc
creation_date: 2016-02-02T15:16:12Z

[Term]
id: GO:1904942
name: regulation of cardiac ventricle formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac ventricle formation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23575307]
is_a: GO:1901210 ! regulation of cardiac chamber formation
is_a: GO:1904412 ! regulation of cardiac ventricle development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003211 ! cardiac ventricle formation
relationship: regulates GO:0003211 ! cardiac ventricle formation
created_by: bc
creation_date: 2016-02-02T16:37:16Z

[Term]
id: GO:1904943
name: negative regulation of cardiac ventricle formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac ventricle formation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23575307]
synonym: "down regulation of cardiac ventricle formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of cardiac ventricle formation" EXACT [GOC:TermGenie]
synonym: "downregulation of cardiac ventricle formation" EXACT [GOC:TermGenie]
synonym: "inhibition of cardiac ventricle formation" NARROW [GOC:TermGenie]
is_a: GO:1901211 ! negative regulation of cardiac chamber formation
is_a: GO:1904413 ! negative regulation of cardiac ventricle development
is_a: GO:1904942 ! regulation of cardiac ventricle formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003211 ! cardiac ventricle formation
relationship: negatively_regulates GO:0003211 ! cardiac ventricle formation
created_by: bc
creation_date: 2016-02-02T16:37:24Z

[Term]
id: GO:1904944
name: positive regulation of cardiac ventricle formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiac ventricle formation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23575307]
synonym: "activation of cardiac ventricle formation" NARROW [GOC:TermGenie]
synonym: "up regulation of cardiac ventricle formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of cardiac ventricle formation" EXACT [GOC:TermGenie]
synonym: "upregulation of cardiac ventricle formation" EXACT [GOC:TermGenie]
is_a: GO:1901212 ! positive regulation of cardiac chamber formation
is_a: GO:1904414 ! positive regulation of cardiac ventricle development
is_a: GO:1904942 ! regulation of cardiac ventricle formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003211 ! cardiac ventricle formation
relationship: positively_regulates GO:0003211 ! cardiac ventricle formation
created_by: bc
creation_date: 2016-02-02T16:37:31Z

[Term]
id: GO:1904945
name: obsolete response to cobalt(II) acetate
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalt(II) acetate stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:24315322]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
is_obsolete: true
created_by: mr
creation_date: 2016-02-02T16:47:52Z

[Term]
id: GO:1904946
name: obsolete cellular response to cobalt(II) acetate
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalt(II) acetate stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:24315322]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
is_obsolete: true
created_by: mr
creation_date: 2016-02-02T16:48:00Z

[Term]
id: GO:1904947
name: folic acid import into mitochondrion
namespace: biological_process
def: "The directed movement of folic acid into a mitochondrion." [GO_REF:0000075, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:15140890]
is_a: GO:0006839 ! mitochondrial transport
is_a: GO:0015884 ! folic acid transport
created_by: rph
creation_date: 2016-02-03T12:10:14Z

[Term]
id: GO:1904948
name: midbrain dopaminergic neuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a midbrain dopaminergic neuron." [GO_REF:0000086, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:17331494, PMID:19122665]
synonym: "DA neurogenesis from midbrain floor plate" EXACT [PMID:19122665]
synonym: "mDA neuron differentiation" EXACT [PMID:24287202]
synonym: "midbrain DA neurogenesis" EXACT [PMID:19122665]
synonym: "midbrain dopaminergic neuron production" EXACT [PMID:19122665]
is_a: GO:0021953 ! central nervous system neuron differentiation
is_a: GO:0071542 ! dopaminergic neuron differentiation
relationship: part_of GO:0030901 ! midbrain development
created_by: bf
creation_date: 2016-02-04T14:38:10Z

[Term]
id: GO:1904949
name: ATPase complex
namespace: cellular_component
def: "A protein complex which is capable of ATPase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:9606181]
comment: An example of this is VPS4 in Saccharomyces cerevisiae (UniProt ID P52917) in PMID:9606181 (inferred from direct assay).
synonym: "VPS4 complex" NARROW []
is_a: GO:1902494 ! catalytic complex
created_by: bhm
creation_date: 2016-02-04T22:13:32Z

[Term]
id: GO:1904950
name: negative regulation of establishment of protein localization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization." [GO_REF:0000058, GOC:TermGenie, PMID:22761445]
synonym: "down regulation of establishment of protein localisation" EXACT [GOC:TermGenie]
synonym: "down regulation of establishment of protein localization" EXACT [GOC:TermGenie]
synonym: "down regulation of protein positioning" EXACT [GOC:TermGenie]
synonym: "down regulation of protein recruitment" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of protein localisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of protein localization" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein positioning" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein recruitment" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of protein localisation" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of protein localization" EXACT [GOC:TermGenie]
synonym: "downregulation of protein positioning" EXACT [GOC:TermGenie]
synonym: "downregulation of protein recruitment" EXACT [GOC:TermGenie]
synonym: "inhibition of establishment of protein localisation" NARROW [GOC:TermGenie]
synonym: "inhibition of establishment of protein localization" NARROW [GOC:TermGenie]
synonym: "inhibition of protein positioning" NARROW [GOC:TermGenie]
synonym: "inhibition of protein recruitment" NARROW [GOC:TermGenie]
synonym: "negative regulation of establishment of protein localisation" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein positioning" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein recruitment" EXACT [GOC:TermGenie]
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0070201 ! regulation of establishment of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045184 ! establishment of protein localization
relationship: negatively_regulates GO:0045184 ! establishment of protein localization
created_by: mec
creation_date: 2016-02-05T09:59:24Z

[Term]
id: GO:1904951
name: positive regulation of establishment of protein localization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment of protein localization." [GO_REF:0000058, GOC:TermGenie, PMID:22761445]
synonym: "activation of establishment of protein localisation" NARROW [GOC:TermGenie]
synonym: "activation of establishment of protein localization" NARROW [GOC:TermGenie]
synonym: "activation of protein positioning" NARROW [GOC:TermGenie]
synonym: "activation of protein recruitment" NARROW [GOC:TermGenie]
synonym: "positive regulation of establishment of protein localisation" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein positioning" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein recruitment" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of protein localisation" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of protein localization" EXACT [GOC:TermGenie]
synonym: "up regulation of protein positioning" EXACT [GOC:TermGenie]
synonym: "up regulation of protein recruitment" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of protein localisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of protein localization" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein positioning" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein recruitment" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of protein localisation" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of protein localization" EXACT [GOC:TermGenie]
synonym: "upregulation of protein positioning" EXACT [GOC:TermGenie]
synonym: "upregulation of protein recruitment" EXACT [GOC:TermGenie]
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:0070201 ! regulation of establishment of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045184 ! establishment of protein localization
relationship: positively_regulates GO:0045184 ! establishment of protein localization
created_by: mec
creation_date: 2016-02-05T09:59:32Z

[Term]
id: GO:1904952
name: hydroxycinnamic acid transport
namespace: biological_process
def: "The directed movement of a hydroxycinnamic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GO_REF:0000065, GOC:TermGenie, PMID:26744218]
is_a: GO:0015718 ! monocarboxylic acid transport
created_by: lr
creation_date: 2016-02-05T22:00:38Z

[Term]
id: GO:1904953
name: Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
namespace: biological_process
def: "Any Wnt signaling pathway that is involved in midbrain dopaminergic neuron differentiation." [GO_REF:0000060, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21347250, PMID:22988876, PMID:23517308]
synonym: "frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "frizzled signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "frizzled signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "frizzled signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "frizzled signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "frizzled signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "frizzled signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "Wg signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "Wg signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "Wg signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "Wg signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "Wg signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "Wg signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "Wg signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "Wg signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "Wg signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "Wg signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "Wingless signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "Wingless signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "Wingless signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "Wingless signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "Wingless signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "Wingless signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "Wnt signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "Wnt signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "Wnt signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate" RELATED [GOC:TermGenie]
synonym: "Wnt-activated signaling pathway involved in mDA neuron differentiation" RELATED [GOC:TermGenie]
synonym: "Wnt-activated signaling pathway involved in midbrain DA neurogenesis" RELATED [GOC:TermGenie]
synonym: "Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation" RELATED [GOC:TermGenie]
synonym: "Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production" RELATED [GOC:TermGenie]
synonym: "Wnt-mediated midbrain DA neuron differentiation" EXACT [PMID:23517308]
is_a: GO:0016055 ! Wnt signaling pathway
intersection_of: GO:0016055 ! Wnt signaling pathway
intersection_of: part_of GO:1904948 ! midbrain dopaminergic neuron differentiation
relationship: part_of GO:1904948 ! midbrain dopaminergic neuron differentiation
created_by: bf
creation_date: 2016-02-08T12:02:07Z

[Term]
id: GO:1904954
name: canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
namespace: biological_process
def: "Any canonical Wnt signaling pathway that is involved in midbrain dopaminergic neuron differentiation." [GO_REF:0000060, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22988876]
synonym: "canonical Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "canonical Wnt receptor signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "canonical Wnt receptor signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "canonical Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "canonical Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "canonical Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "canonical Wnt signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "canonical Wnt signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "canonical Wnt signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "canonical Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "canonical Wnt-activated signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "canonical Wnt-activated signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "canonical Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "canonical Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "canonical Wnt-mediated midbrain DA neuron differentiation" EXACT [GOC:bf]
synonym: "frizzled-1 receptor signaling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie]
synonym: "frizzled-1 receptor signaling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie]
synonym: "frizzled-1 receptor signaling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie]
synonym: "frizzled-1 receptor signaling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie]
synonym: "frizzled-1 receptor signaling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie]
synonym: "Wnt receptor signaling pathway through beta-catenin involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signaling pathway through beta-catenin involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signaling pathway through beta-catenin involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signaling pathway through beta-catenin involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signaling pathway through beta-catenin involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signaling pathway via beta-catenin involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signaling pathway via beta-catenin involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signaling pathway via beta-catenin involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signaling pathway via beta-catenin involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signaling pathway via beta-catenin involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signalling pathway through beta-catenin involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signalling pathway through beta-catenin involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signalling pathway through beta-catenin involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signalling pathway through beta-catenin involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signalling pathway through beta-catenin involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
is_a: GO:0060070 ! canonical Wnt signaling pathway
is_a: GO:1904953 ! Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
intersection_of: GO:0060070 ! canonical Wnt signaling pathway
intersection_of: part_of GO:1904948 ! midbrain dopaminergic neuron differentiation
relationship: part_of GO:1904948 ! midbrain dopaminergic neuron differentiation
created_by: bf
creation_date: 2016-02-09T11:04:46Z

[Term]
id: GO:1904955
name: planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation
namespace: biological_process
def: "Any Wnt signaling pathway, planar cell polarity pathway that is involved in midbrain dopaminergic neuron differentiation." [GO_REF:0000060, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22988876]
synonym: "non-canonical Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate" BROAD [GOC:TermGenie]
synonym: "non-canonical Wnt signaling pathway involved in mDA neuron differentiation" BROAD [GOC:TermGenie]
synonym: "non-canonical Wnt signaling pathway involved in midbrain DA neurogenesis" BROAD [GOC:TermGenie]
synonym: "non-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation" BROAD [GOC:TermGenie]
synonym: "non-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron production" BROAD [GOC:TermGenie]
synonym: "non-canonical Wnt-mediated midbrain DA neuron differentiation" BROAD [GOC:bf]
synonym: "PCP pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "PCP pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "PCP pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "PCP pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "PCP pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "planar cell polarity pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "planar cell polarity pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "planar cell polarity pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "planar cell polarity pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signaling pathway, planar cell polarity pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signaling pathway, planar cell polarity pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signaling pathway, planar cell polarity pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signaling pathway, planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signaling pathway, planar cell polarity pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signalling pathway, planar cell polarity pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signalling pathway, planar cell polarity pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signalling pathway, planar cell polarity pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signalling pathway, planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "Wnt receptor signalling pathway, planar cell polarity pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "Wnt signaling pathway, planar cell polarity pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "Wnt signaling pathway, planar cell polarity pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "Wnt signaling pathway, planar cell polarity pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "Wnt signaling pathway, planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation" EXACT []
synonym: "Wnt signaling pathway, planar cell polarity pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "Wnt-activated signaling pathway, planar cell polarity pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "Wnt-activated signaling pathway, planar cell polarity pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "Wnt-activated signaling pathway, planar cell polarity pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "Wnt-activated signaling pathway, planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "Wnt-activated signaling pathway, planar cell polarity pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "Wnt-JNK signaling pathway involved in DA neurogenesis from midbrain floor plate" RELATED [GOC:TermGenie]
synonym: "Wnt-JNK signaling pathway involved in mDA neuron differentiation" RELATED [GOC:TermGenie]
synonym: "Wnt-JNK signaling pathway involved in midbrain DA neurogenesis" RELATED [GOC:TermGenie]
synonym: "Wnt-JNK signaling pathway involved in midbrain dopaminergic neuron differentiation" RELATED [GOC:TermGenie]
synonym: "Wnt-JNK signaling pathway involved in midbrain dopaminergic neuron production" RELATED [GOC:TermGenie]
synonym: "Wnt-PCP signaling pathway involved in DA neurogenesis from midbrain floor plate" RELATED [GOC:TermGenie]
synonym: "Wnt-PCP signaling pathway involved in mDA neuron differentiation" RELATED [GOC:TermGenie]
synonym: "Wnt-PCP signaling pathway involved in midbrain DA neurogenesis" RELATED [GOC:TermGenie]
synonym: "Wnt-PCP signaling pathway involved in midbrain dopaminergic neuron differentiation" RELATED [GOC:TermGenie]
synonym: "Wnt-PCP signaling pathway involved in midbrain dopaminergic neuron production" RELATED [GOC:TermGenie]
is_a: GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway
is_a: GO:1904953 ! Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
intersection_of: GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway
intersection_of: part_of GO:1904948 ! midbrain dopaminergic neuron differentiation
relationship: part_of GO:1904948 ! midbrain dopaminergic neuron differentiation
created_by: bf
creation_date: 2016-02-09T11:04:56Z

[Term]
id: GO:1904956
name: regulation of midbrain dopaminergic neuron differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of midbrain dopaminergic neuron differentiation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21347250]
synonym: "regulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "regulation of mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "regulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
is_a: GO:1904338 ! regulation of dopaminergic neuron differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1904948 ! midbrain dopaminergic neuron differentiation
relationship: regulates GO:1904948 ! midbrain dopaminergic neuron differentiation
created_by: bf
creation_date: 2016-02-09T12:00:21Z

[Term]
id: GO:1904957
name: negative regulation of midbrain dopaminergic neuron differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of midbrain dopaminergic neuron differentiation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "down regulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "down regulation of mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "down-regulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "down-regulation of mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "downregulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "downregulation of mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "inhibition of DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie]
synonym: "inhibition of mDA neuron differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of midbrain DA neurogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of midbrain dopaminergic neuron production" NARROW [GOC:TermGenie]
synonym: "negative regulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "negative regulation of mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "negative regulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
is_a: GO:1904339 ! negative regulation of dopaminergic neuron differentiation
is_a: GO:1904956 ! regulation of midbrain dopaminergic neuron differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1904948 ! midbrain dopaminergic neuron differentiation
relationship: negatively_regulates GO:1904948 ! midbrain dopaminergic neuron differentiation
created_by: bf
creation_date: 2016-02-09T12:00:29Z

[Term]
id: GO:1904958
name: positive regulation of midbrain dopaminergic neuron differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of midbrain dopaminergic neuron differentiation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21347250]
synonym: "activation of DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie]
synonym: "activation of mDA neuron differentiation" NARROW [GOC:TermGenie]
synonym: "activation of midbrain DA neurogenesis" NARROW [GOC:TermGenie]
synonym: "activation of midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie]
synonym: "activation of midbrain dopaminergic neuron production" NARROW [GOC:TermGenie]
synonym: "positive regulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "positive regulation of mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "up regulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "up regulation of mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "up-regulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "up-regulation of mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "upregulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "upregulation of mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
is_a: GO:1904340 ! positive regulation of dopaminergic neuron differentiation
is_a: GO:1904956 ! regulation of midbrain dopaminergic neuron differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1904948 ! midbrain dopaminergic neuron differentiation
relationship: positively_regulates GO:1904948 ! midbrain dopaminergic neuron differentiation
created_by: bf
creation_date: 2016-02-09T12:00:36Z

[Term]
id: GO:1904959
name: regulation of cytochrome-c oxidase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cytochrome-c oxidase activity." [GO_REF:0000059, GOC:TermGenie, PMID:26734017]
synonym: "regulation of aa3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "regulation of ba3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "regulation of caa3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "regulation of cbb3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "regulation of complex IV (mitochondrial electron transport) activity" RELATED [GOC:TermGenie]
synonym: "regulation of cytochrome a3 activity" NARROW [GOC:TermGenie]
synonym: "regulation of cytochrome aa3 activity" NARROW [GOC:TermGenie]
synonym: "regulation of cytochrome c oxidase activity" EXACT [GOC:TermGenie]
synonym: "regulation of cytochrome oxidase activity" RELATED [GOC:TermGenie]
synonym: "regulation of ferrocytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "regulation of ferrocytochrome-c:oxygen oxidoreductase" NARROW [GOC:TermGenie]
synonym: "regulation of indophenol oxidase" NARROW [GOC:TermGenie]
synonym: "regulation of indophenolase" NARROW [GOC:TermGenie]
synonym: "regulation of NADH cytochrome c oxidase" EXACT [GOC:TermGenie]
synonym: "regulation of warburg's respiratory enzyme activity" RELATED [GOC:TermGenie]
is_a: GO:0010155 ! regulation of proton transport
is_a: GO:0032412 ! regulation of ion transmembrane transporter activity
is_a: GO:0051341 ! regulation of oxidoreductase activity
is_a: GO:1904062 ! regulation of cation transmembrane transport
is_a: GO:1904732 ! regulation of electron carrier activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004129 ! cytochrome-c oxidase activity
relationship: regulates GO:0004129 ! cytochrome-c oxidase activity
created_by: tb
creation_date: 2016-02-09T22:18:27Z

[Term]
id: GO:1904960
name: positive regulation of cytochrome-c oxidase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cytochrome-c oxidase activity." [GO_REF:0000059, GOC:TermGenie, PMID:26734017]
synonym: "activation of aa3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "activation of ba3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "activation of caa3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "activation of cbb3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "activation of complex IV (mitochondrial electron transport) activity" RELATED [GOC:TermGenie]
synonym: "activation of cytochrome a3 activity" NARROW [GOC:TermGenie]
synonym: "activation of cytochrome aa3 activity" NARROW [GOC:TermGenie]
synonym: "activation of cytochrome c oxidase activity" NARROW [GOC:TermGenie]
synonym: "activation of cytochrome oxidase activity" RELATED [GOC:TermGenie]
synonym: "activation of cytochrome-c oxidase activity" NARROW [GOC:TermGenie]
synonym: "activation of ferrocytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "activation of ferrocytochrome-c:oxygen oxidoreductase" NARROW [GOC:TermGenie]
synonym: "activation of indophenol oxidase" NARROW [GOC:TermGenie]
synonym: "activation of indophenolase" NARROW [GOC:TermGenie]
synonym: "activation of NADH cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "activation of warburg's respiratory enzyme activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of aa3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "positive regulation of ba3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "positive regulation of caa3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "positive regulation of cbb3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "positive regulation of complex IV (mitochondrial electron transport) activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of cytochrome a3 activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of cytochrome aa3 activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of cytochrome c oxidase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of cytochrome oxidase activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of ferrocytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "positive regulation of ferrocytochrome-c:oxygen oxidoreductase" NARROW [GOC:TermGenie]
synonym: "positive regulation of indophenol oxidase" NARROW [GOC:TermGenie]
synonym: "positive regulation of indophenolase" NARROW [GOC:TermGenie]
synonym: "positive regulation of NADH cytochrome c oxidase" EXACT [GOC:TermGenie]
synonym: "positive regulation of warburg's respiratory enzyme activity" RELATED [GOC:TermGenie]
synonym: "up regulation of aa3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "up regulation of ba3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "up regulation of caa3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "up regulation of cbb3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "up regulation of complex IV (mitochondrial electron transport) activity" RELATED [GOC:TermGenie]
synonym: "up regulation of cytochrome a3 activity" NARROW [GOC:TermGenie]
synonym: "up regulation of cytochrome aa3 activity" NARROW [GOC:TermGenie]
synonym: "up regulation of cytochrome c oxidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of cytochrome oxidase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of cytochrome-c oxidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of ferrocytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "up regulation of ferrocytochrome-c:oxygen oxidoreductase" NARROW [GOC:TermGenie]
synonym: "up regulation of indophenol oxidase" NARROW [GOC:TermGenie]
synonym: "up regulation of indophenolase" NARROW [GOC:TermGenie]
synonym: "up regulation of NADH cytochrome c oxidase" EXACT [GOC:TermGenie]
synonym: "up regulation of warburg's respiratory enzyme activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of aa3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "up-regulation of ba3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "up-regulation of caa3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "up-regulation of cbb3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "up-regulation of complex IV (mitochondrial electron transport) activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of cytochrome a3 activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of cytochrome aa3 activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of cytochrome c oxidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of cytochrome oxidase activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of cytochrome-c oxidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of ferrocytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "up-regulation of ferrocytochrome-c:oxygen oxidoreductase" NARROW [GOC:TermGenie]
synonym: "up-regulation of indophenol oxidase" NARROW [GOC:TermGenie]
synonym: "up-regulation of indophenolase" NARROW [GOC:TermGenie]
synonym: "up-regulation of NADH cytochrome c oxidase" EXACT [GOC:TermGenie]
synonym: "up-regulation of warburg's respiratory enzyme activity" RELATED [GOC:TermGenie]
synonym: "upregulation of aa3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "upregulation of ba3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "upregulation of caa3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "upregulation of cbb3-type cytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "upregulation of complex IV (mitochondrial electron transport) activity" RELATED [GOC:TermGenie]
synonym: "upregulation of cytochrome a3 activity" NARROW [GOC:TermGenie]
synonym: "upregulation of cytochrome aa3 activity" NARROW [GOC:TermGenie]
synonym: "upregulation of cytochrome c oxidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of cytochrome oxidase activity" RELATED [GOC:TermGenie]
synonym: "upregulation of cytochrome-c oxidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of ferrocytochrome c oxidase" NARROW [GOC:TermGenie]
synonym: "upregulation of ferrocytochrome-c:oxygen oxidoreductase" NARROW [GOC:TermGenie]
synonym: "upregulation of indophenol oxidase" NARROW [GOC:TermGenie]
synonym: "upregulation of indophenolase" NARROW [GOC:TermGenie]
synonym: "upregulation of NADH cytochrome c oxidase" EXACT [GOC:TermGenie]
synonym: "upregulation of warburg's respiratory enzyme activity" RELATED [GOC:TermGenie]
is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity
is_a: GO:0051353 ! positive regulation of oxidoreductase activity
is_a: GO:1904064 ! positive regulation of cation transmembrane transport
is_a: GO:1904734 ! positive regulation of electron carrier activity
is_a: GO:1904959 ! regulation of cytochrome-c oxidase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004129 ! cytochrome-c oxidase activity
relationship: positively_regulates GO:0004129 ! cytochrome-c oxidase activity
created_by: tb
creation_date: 2016-02-09T22:18:43Z

[Term]
id: GO:1904961
name: quiescent center organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the quiescent center. This process pertains to the physical shaping of a rudimentary structure." [GO_REF:0000084, GOC:TermGenie, PMID:21233333]
synonym: "quiescent center structural organization" EXACT []
is_a: GO:0048532 ! anatomical structure arrangement
created_by: tb
creation_date: 2016-02-10T00:11:00Z

[Term]
id: GO:1904962
name: plastid to vacuole vesicle-mediated transport
namespace: biological_process
def: "The vesicle-mediated and directed movement of substances from plastid to vacuole." [GO_REF:0000076, GOC:TermGenie, PMID:25281689]
synonym: "plastid to vacuolar carboxypeptidase Y vesicle-mediated transport" RELATED [GOC:TermGenie]
is_a: GO:0007034 ! vacuolar transport
is_a: GO:0016192 ! vesicle-mediated transport
is_a: GO:0016482 ! cytosolic transport
relationship: occurs_in GO:0005829 ! cytosol
created_by: tb
creation_date: 2016-02-10T00:14:48Z

[Term]
id: GO:1904963
name: regulation of phytol biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phytol biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:24275650]
synonym: "regulation of phytol anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of phytol biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of phytol formation" EXACT [GOC:TermGenie]
synonym: "regulation of phytol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0019747 ! regulation of isoprenoid metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0046890 ! regulation of lipid biosynthetic process
is_a: GO:1902930 ! regulation of alcohol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0033520 ! phytol biosynthetic process
relationship: regulates GO:0033520 ! phytol biosynthetic process
created_by: tb
creation_date: 2016-02-11T00:41:51Z

[Term]
id: GO:1904964
name: positive regulation of phytol biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phytol biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:24275650]
synonym: "activation of phytol anabolism" NARROW [GOC:TermGenie]
synonym: "activation of phytol biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of phytol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of phytol formation" NARROW [GOC:TermGenie]
synonym: "activation of phytol synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of phytol anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of phytol biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of phytol formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of phytol synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of phytol anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of phytol biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of phytol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of phytol formation" EXACT [GOC:TermGenie]
synonym: "up regulation of phytol synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of phytol anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of phytol biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of phytol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of phytol formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of phytol synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of phytol anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of phytol biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of phytol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of phytol formation" EXACT [GOC:TermGenie]
synonym: "upregulation of phytol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process
is_a: GO:0046889 ! positive regulation of lipid biosynthetic process
is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process
is_a: GO:1904963 ! regulation of phytol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0033520 ! phytol biosynthetic process
relationship: positively_regulates GO:0033520 ! phytol biosynthetic process
created_by: tb
creation_date: 2016-02-11T00:42:07Z

[Term]
id: GO:1904965
name: regulation of vitamin E biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vitamin E biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:20823244]
synonym: "regulation of alpha-tocopherol biosynthesis" NARROW [GOC:TermGenie]
synonym: "regulation of alpha-tocopherol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "regulation of tocopherol biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of tocopherol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "regulation of vitamin E anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of vitamin E biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of vitamin E formation" EXACT [GOC:TermGenie]
synonym: "regulation of vitamin E synthesis" EXACT [GOC:TermGenie]
is_a: GO:0030656 ! regulation of vitamin metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010189 ! vitamin E biosynthetic process
relationship: regulates GO:0010189 ! vitamin E biosynthetic process
created_by: tb
creation_date: 2016-02-12T17:56:55Z

[Term]
id: GO:1904966
name: positive regulation of vitamin E biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vitamin E biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:20823244]
synonym: "activation of alpha-tocopherol biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of alpha-tocopherol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of tocopherol biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of tocopherol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of vitamin E anabolism" NARROW [GOC:TermGenie]
synonym: "activation of vitamin E biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of vitamin E biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of vitamin E formation" NARROW [GOC:TermGenie]
synonym: "activation of vitamin E synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of alpha-tocopherol biosynthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of alpha-tocopherol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of tocopherol biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of tocopherol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of vitamin E anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of vitamin E biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of vitamin E formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of vitamin E synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of alpha-tocopherol biosynthesis" NARROW [GOC:TermGenie]
synonym: "up regulation of alpha-tocopherol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "up regulation of tocopherol biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of tocopherol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of vitamin E anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of vitamin E biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of vitamin E biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of vitamin E formation" EXACT [GOC:TermGenie]
synonym: "up regulation of vitamin E synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of alpha-tocopherol biosynthesis" NARROW [GOC:TermGenie]
synonym: "up-regulation of alpha-tocopherol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "up-regulation of tocopherol biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of tocopherol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of vitamin E anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of vitamin E biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of vitamin E biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of vitamin E formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of vitamin E synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of alpha-tocopherol biosynthesis" NARROW [GOC:TermGenie]
synonym: "upregulation of alpha-tocopherol biosynthetic process" NARROW [GOC:TermGenie]
synonym: "upregulation of tocopherol biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of tocopherol biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of vitamin E anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of vitamin E biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of vitamin E biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of vitamin E formation" EXACT [GOC:TermGenie]
synonym: "upregulation of vitamin E synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0046136 ! positive regulation of vitamin metabolic process
is_a: GO:1904965 ! regulation of vitamin E biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010189 ! vitamin E biosynthetic process
relationship: positively_regulates GO:0010189 ! vitamin E biosynthetic process
created_by: tb
creation_date: 2016-02-12T17:57:03Z

[Term]
id: GO:1904967
name: regulation of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation." [GO_REF:0000058, GOC:TermGenie, PMID:23770679]
synonym: "regulation of attachment of spindle microtubules to kinetochore during meiosis I" RELATED [GOC:TermGenie]
synonym: "regulation of attachment of spindle microtubules to kinetochore involved in meiosis I" EXACT [GOC:TermGenie]
synonym: "regulation of monopolar attachment" EXACT [GOC:TermGenie]
synonym: "regulation of sister kinetochore mono-orientation" EXACT [GOC:TermGenie]
is_a: GO:0051988 ! regulation of attachment of spindle microtubules to kinetochore
is_a: GO:0060629 ! regulation of homologous chromosome segregation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051455 ! attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation
relationship: regulates GO:0051455 ! attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation
created_by: mah
creation_date: 2016-02-15T15:19:12Z

[Term]
id: GO:1904968
name: positive regulation of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation." [GO_REF:0000058, GOC:TermGenie, PMID:23770679]
synonym: "activation of attachment of spindle microtubules to kinetochore during meiosis I" RELATED [GOC:TermGenie]
synonym: "activation of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation" NARROW [GOC:TermGenie]
synonym: "activation of attachment of spindle microtubules to kinetochore involved in meiosis I" NARROW [GOC:TermGenie]
synonym: "activation of monopolar attachment" NARROW [GOC:TermGenie]
synonym: "activation of sister kinetochore mono-orientation" NARROW [GOC:TermGenie]
synonym: "positive regulation of attachment of spindle microtubules to kinetochore during meiosis I" RELATED [GOC:TermGenie]
synonym: "positive regulation of attachment of spindle microtubules to kinetochore involved in meiosis I" EXACT [GOC:TermGenie]
synonym: "positive regulation of monopolar attachment" EXACT [GOC:TermGenie]
synonym: "positive regulation of sister kinetochore mono-orientation" EXACT [GOC:TermGenie]
synonym: "up regulation of attachment of spindle microtubules to kinetochore during meiosis I" RELATED [GOC:TermGenie]
synonym: "up regulation of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation" EXACT [GOC:TermGenie]
synonym: "up regulation of attachment of spindle microtubules to kinetochore involved in meiosis I" EXACT [GOC:TermGenie]
synonym: "up regulation of monopolar attachment" EXACT [GOC:TermGenie]
synonym: "up regulation of sister kinetochore mono-orientation" EXACT [GOC:TermGenie]
synonym: "up-regulation of attachment of spindle microtubules to kinetochore during meiosis I" RELATED [GOC:TermGenie]
synonym: "up-regulation of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation" EXACT [GOC:TermGenie]
synonym: "up-regulation of attachment of spindle microtubules to kinetochore involved in meiosis I" EXACT [GOC:TermGenie]
synonym: "up-regulation of monopolar attachment" EXACT [GOC:TermGenie]
synonym: "up-regulation of sister kinetochore mono-orientation" EXACT [GOC:TermGenie]
synonym: "upregulation of attachment of spindle microtubules to kinetochore during meiosis I" RELATED [GOC:TermGenie]
synonym: "upregulation of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation" EXACT [GOC:TermGenie]
synonym: "upregulation of attachment of spindle microtubules to kinetochore involved in meiosis I" EXACT [GOC:TermGenie]
synonym: "upregulation of monopolar attachment" EXACT [GOC:TermGenie]
synonym: "upregulation of sister kinetochore mono-orientation" EXACT [GOC:TermGenie]
is_a: GO:0051987 ! positive regulation of attachment of spindle microtubules to kinetochore
is_a: GO:0060903 ! positive regulation of meiosis I
is_a: GO:1904967 ! regulation of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051455 ! attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation
relationship: positively_regulates GO:0051455 ! attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation
created_by: mah
creation_date: 2016-02-15T15:19:20Z

[Term]
id: GO:1904969
name: slow muscle cell migration
namespace: biological_process
def: "The orderly movement of a slow muscle cell from one site to another." [GO_REF:0000091, GOC:TermGenie, GOC:ymb, PMID:14667409, PMID:15572133, PMID:25534553]
comment: The directional migration of a slow muscle cell from one site to another within the embryo.
synonym: "slow-twitch muscle cell migration" EXACT [PMID:14667409]
is_a: GO:0014812 ! muscle cell migration
created_by: ymb
creation_date: 2016-02-16T21:20:11Z

[Term]
id: GO:1904970
name: brush border assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of adjacent microvilli through the formation of Ca(2+)-dependent adhesion links between them, forming a brush border." [GO_REF:0000079, GOC:lb, GOC:TermGenie, PMID:24725409]
synonym: "brush border formation" EXACT [GOC:TermGenie]
is_a: GO:0022607 ! cellular component assembly
created_by: tb
creation_date: 2016-02-17T00:58:30Z

[Term]
id: GO:1904971
name: regulation of viral translation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of viral translation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:19666601]
synonym: "regulation of viral protein anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of viral protein biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of viral protein biosynthetic process" EXACT [GOC:TermGenie]
synonym: "regulation of viral protein formation" EXACT [GOC:TermGenie]
synonym: "regulation of viral protein synthesis" EXACT [GOC:TermGenie]
is_a: GO:0006417 ! regulation of translation
is_a: GO:1903900 ! regulation of viral life cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019081 ! viral translation
relationship: regulates GO:0019081 ! viral translation
created_by: bhm
creation_date: 2016-02-17T15:52:59Z

[Term]
id: GO:1904972
name: negative regulation of viral translation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of viral translation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:19666601]
synonym: "down regulation of viral protein anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of viral protein biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of viral protein biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of viral protein formation" EXACT [GOC:TermGenie]
synonym: "down regulation of viral protein synthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of viral translation" EXACT [GOC:TermGenie]
synonym: "down-regulation of viral protein anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of viral protein biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of viral protein biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of viral protein formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of viral protein synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of viral translation" EXACT [GOC:TermGenie]
synonym: "downregulation of viral protein anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of viral protein biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of viral protein biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of viral protein formation" EXACT [GOC:TermGenie]
synonym: "downregulation of viral protein synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of viral translation" EXACT [GOC:TermGenie]
synonym: "inhibition of viral protein anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of viral protein biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of viral protein biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of viral protein formation" NARROW [GOC:TermGenie]
synonym: "inhibition of viral protein synthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of viral translation" NARROW [GOC:TermGenie]
synonym: "negative regulation of viral protein anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of viral protein biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of viral protein biosynthetic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of viral protein formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of viral protein synthesis" EXACT [GOC:TermGenie]
is_a: GO:0017148 ! negative regulation of translation
is_a: GO:1903901 ! negative regulation of viral life cycle
is_a: GO:1904971 ! regulation of viral translation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019081 ! viral translation
relationship: negatively_regulates GO:0019081 ! viral translation
created_by: bhm
creation_date: 2016-02-17T15:53:08Z

[Term]
id: GO:1904973
name: positive regulation of viral translation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of viral translation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:19666601]
synonym: "activation of viral protein anabolism" NARROW [GOC:TermGenie]
synonym: "activation of viral protein biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of viral protein biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of viral protein formation" NARROW [GOC:TermGenie]
synonym: "activation of viral protein synthesis" NARROW [GOC:TermGenie]
synonym: "activation of viral translation" NARROW [GOC:TermGenie]
synonym: "positive regulation of viral protein anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of viral protein biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of viral protein biosynthetic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of viral protein formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of viral protein synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of viral protein anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of viral protein biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of viral protein biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of viral protein formation" EXACT [GOC:TermGenie]
synonym: "up regulation of viral protein synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of viral translation" EXACT [GOC:TermGenie]
synonym: "up-regulation of viral protein anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of viral protein biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of viral protein biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of viral protein formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of viral protein synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of viral translation" EXACT [GOC:TermGenie]
synonym: "upregulation of viral protein anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of viral protein biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of viral protein biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of viral protein formation" EXACT [GOC:TermGenie]
synonym: "upregulation of viral protein synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of viral translation" EXACT [GOC:TermGenie]
is_a: GO:0045727 ! positive regulation of translation
is_a: GO:1903902 ! positive regulation of viral life cycle
is_a: GO:1904971 ! regulation of viral translation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0019081 ! viral translation
relationship: positively_regulates GO:0019081 ! viral translation
created_by: bhm
creation_date: 2016-02-17T15:53:15Z

[Term]
id: GO:1904974
name: heparanase complex
namespace: cellular_component
def: "A protein complex which is capable of heparanase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:12927802]
comment: An example of this is HPSE in human (Q9Y251) in PMID:12927802 (inferred from direct assay).
synonym: "HEPS complex" EXACT []
is_a: GO:1902494 ! catalytic complex
created_by: bhm
creation_date: 2016-02-18T11:50:39Z

[Term]
id: GO:1904975
name: response to bleomycin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bleomycin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:11553781]
is_a: GO:1901652 ! response to peptide
created_by: mah
creation_date: 2016-02-18T15:21:23Z

[Term]
id: GO:1904976
name: cellular response to bleomycin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bleomycin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:11553781]
is_a: GO:1901653 ! cellular response to peptide
is_a: GO:1904975 ! response to bleomycin
created_by: mah
creation_date: 2016-02-18T15:21:31Z

[Term]
id: GO:1904977
name: lymphatic endothelial cell migration
namespace: biological_process
def: "The orderly movement of a lymphatic endothelial cell from one site to another in the wall of a lymphatic vessel." [GO_REF:0000091, GOC:TermGenie, PMID:25745057]
is_a: GO:0043542 ! endothelial cell migration
relationship: part_of GO:0036303 ! lymph vessel morphogenesis
created_by: dgh
creation_date: 2016-02-18T20:49:43Z

[Term]
id: GO:1904978
name: regulation of endosome organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endosome organization." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22511594]
synonym: "regulation of endosome organisation" EXACT [GOC:TermGenie]
synonym: "regulation of endosome organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0044088 ! regulation of vacuole organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007032 ! endosome organization
relationship: regulates GO:0007032 ! endosome organization
created_by: pad
creation_date: 2016-02-22T19:21:01Z

[Term]
id: GO:1904979
name: negative regulation of endosome organization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of endosome organization." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22511594]
synonym: "down regulation of endosome organisation" EXACT [GOC:TermGenie]
synonym: "down regulation of endosome organization" EXACT [GOC:TermGenie]
synonym: "down regulation of endosome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of endosome organisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of endosome organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of endosome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "downregulation of endosome organisation" EXACT [GOC:TermGenie]
synonym: "downregulation of endosome organization" EXACT [GOC:TermGenie]
synonym: "downregulation of endosome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "inhibition of endosome organisation" NARROW [GOC:TermGenie]
synonym: "inhibition of endosome organization" NARROW [GOC:TermGenie]
synonym: "inhibition of endosome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of endosome organisation" EXACT [GOC:TermGenie]
synonym: "negative regulation of endosome organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:1904978 ! regulation of endosome organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007032 ! endosome organization
relationship: negatively_regulates GO:0007032 ! endosome organization
created_by: pad
creation_date: 2016-02-22T19:21:08Z

[Term]
id: GO:1904980
name: positive regulation of endosome organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endosome organization." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22511594]
synonym: "activation of endosome organisation" NARROW [GOC:TermGenie]
synonym: "activation of endosome organization" NARROW [GOC:TermGenie]
synonym: "activation of endosome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of endosome organisation" EXACT [GOC:TermGenie]
synonym: "positive regulation of endosome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "up regulation of endosome organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of endosome organization" EXACT [GOC:TermGenie]
synonym: "up regulation of endosome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of endosome organisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of endosome organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of endosome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "upregulation of endosome organisation" EXACT [GOC:TermGenie]
synonym: "upregulation of endosome organization" EXACT [GOC:TermGenie]
synonym: "upregulation of endosome organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0044090 ! positive regulation of vacuole organization
is_a: GO:1904978 ! regulation of endosome organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007032 ! endosome organization
relationship: positively_regulates GO:0007032 ! endosome organization
created_by: pad
creation_date: 2016-02-22T19:21:16Z

[Term]
id: GO:1904981
name: maltose transmembrane transport
namespace: biological_process
def: "The directed movement of maltose across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:11136464]
is_a: GO:0015768 ! maltose transport
is_a: GO:0034219 ! carbohydrate transmembrane transport
created_by: vw
creation_date: 2016-02-28T21:14:04Z

[Term]
id: GO:1904982
name: sucrose transmembrane transport
namespace: biological_process
def: "The directed movement of sucrose across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:11136464]
is_a: GO:0015770 ! sucrose transport
is_a: GO:0034219 ! carbohydrate transmembrane transport
created_by: vw
creation_date: 2016-02-28T21:16:51Z

[Term]
id: GO:1904983
name: transmembrane glycine transport from cytosol to mitochondrion
namespace: biological_process
def: "The directed movement of glycine across a membrane from cytosol to mitochondrion." [GO_REF:0000078, GOC:TermGenie, PMID:26821380]
is_a: GO:0015816 ! glycine transport
is_a: GO:0098655 ! cation transmembrane transport
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport
is_a: GO:1990542 ! mitochondrial transmembrane transport
created_by: vw
creation_date: 2016-02-28T21:53:44Z

[Term]
id: GO:1904984
name: regulation of quinolinate biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of quinolinate biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:12140278, PMID:19843166]
synonym: "regulation of quinolinate anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of quinolinate biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of quinolinate formation" EXACT [GOC:TermGenie]
synonym: "regulation of quinolinate synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019805 ! quinolinate biosynthetic process
relationship: regulates GO:0019805 ! quinolinate biosynthetic process
created_by: bf
creation_date: 2016-02-29T15:54:12Z

[Term]
id: GO:1904985
name: negative regulation of quinolinate biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of quinolinate biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:12140278, PMID:19843166]
synonym: "down regulation of quinolinate anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of quinolinate biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of quinolinate biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of quinolinate formation" EXACT [GOC:TermGenie]
synonym: "down regulation of quinolinate synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of quinolinate anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of quinolinate biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of quinolinate biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of quinolinate formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of quinolinate synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of quinolinate anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of quinolinate biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of quinolinate biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of quinolinate formation" EXACT [GOC:TermGenie]
synonym: "downregulation of quinolinate synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of quinolinate anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of quinolinate biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of quinolinate biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of quinolinate formation" NARROW [GOC:TermGenie]
synonym: "inhibition of quinolinate synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of quinolinate anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of quinolinate biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of quinolinate formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of quinolinate synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process
is_a: GO:1904984 ! regulation of quinolinate biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019805 ! quinolinate biosynthetic process
relationship: negatively_regulates GO:0019805 ! quinolinate biosynthetic process
created_by: bf
creation_date: 2016-02-29T15:54:21Z

[Term]
id: GO:1904986
name: positive regulation of quinolinate biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of quinolinate biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "activation of quinolinate anabolism" NARROW [GOC:TermGenie]
synonym: "activation of quinolinate biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of quinolinate biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of quinolinate formation" NARROW [GOC:TermGenie]
synonym: "activation of quinolinate synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of quinolinate anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of quinolinate biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of quinolinate formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of quinolinate synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of quinolinate anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of quinolinate biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of quinolinate biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of quinolinate formation" EXACT [GOC:TermGenie]
synonym: "up regulation of quinolinate synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of quinolinate anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of quinolinate biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of quinolinate biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of quinolinate formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of quinolinate synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of quinolinate anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of quinolinate biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of quinolinate biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of quinolinate formation" EXACT [GOC:TermGenie]
synonym: "upregulation of quinolinate synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process
is_a: GO:1904984 ! regulation of quinolinate biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0019805 ! quinolinate biosynthetic process
relationship: positively_regulates GO:0019805 ! quinolinate biosynthetic process
created_by: bf
creation_date: 2016-02-29T15:54:29Z

[Term]
id: GO:1904987
name: regulation of endothelial cell activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endothelial cell activation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:24255059]
is_a: GO:0050865 ! regulation of cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042118 ! endothelial cell activation
relationship: regulates GO:0042118 ! endothelial cell activation
created_by: bc
creation_date: 2016-02-29T16:16:09Z

[Term]
id: GO:1904988
name: negative regulation of endothelial cell activation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell activation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:24255059]
synonym: "down regulation of endothelial cell activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of endothelial cell activation" EXACT [GOC:TermGenie]
synonym: "downregulation of endothelial cell activation" EXACT [GOC:TermGenie]
synonym: "inhibition of endothelial cell activation" NARROW [GOC:TermGenie]
is_a: GO:0050866 ! negative regulation of cell activation
is_a: GO:1904987 ! regulation of endothelial cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042118 ! endothelial cell activation
relationship: negatively_regulates GO:0042118 ! endothelial cell activation
created_by: bc
creation_date: 2016-02-29T16:16:18Z

[Term]
id: GO:1904989
name: positive regulation of endothelial cell activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endothelial cell activation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:24255059]
synonym: "activation of endothelial cell activation" NARROW [GOC:TermGenie]
synonym: "up regulation of endothelial cell activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of endothelial cell activation" EXACT [GOC:TermGenie]
synonym: "upregulation of endothelial cell activation" EXACT [GOC:TermGenie]
is_a: GO:0050867 ! positive regulation of cell activation
is_a: GO:1904987 ! regulation of endothelial cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042118 ! endothelial cell activation
relationship: positively_regulates GO:0042118 ! endothelial cell activation
created_by: bc
creation_date: 2016-02-29T16:16:25Z

[Term]
id: GO:1904990
name: regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of adenylate cyclase-inhibiting dopamine receptor signaling pathway." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:26554819]
synonym: "regulation of dopamine receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:TermGenie]
synonym: "regulation of dopamine receptor, adenylyl cyclase inhibiting pathway" EXACT [GOC:TermGenie]
synonym: "regulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "regulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0060159 ! regulation of dopamine receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007195 ! adenylate cyclase-inhibiting dopamine receptor signaling pathway
relationship: regulates GO:0007195 ! adenylate cyclase-inhibiting dopamine receptor signaling pathway
created_by: kmv
creation_date: 2016-02-29T22:42:16Z

[Term]
id: GO:1904991
name: negative regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of adenylate cyclase-inhibiting dopamine receptor signaling pathway." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:26554819]
synonym: "down regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of dopamine receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of dopamine receptor, adenylyl cyclase inhibiting pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "down regulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of dopamine receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of dopamine receptor, adenylyl cyclase inhibiting pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "down-regulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of dopamine receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of dopamine receptor, adenylyl cyclase inhibiting pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "downregulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of adenylate cyclase-inhibiting dopamine receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of dopamine receptor, adenylate cyclase inhibiting pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of dopamine receptor, adenylyl cyclase inhibiting pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "inhibition of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of dopamine receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of dopamine receptor, adenylyl cyclase inhibiting pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0060160 ! negative regulation of dopamine receptor signaling pathway
is_a: GO:1904990 ! regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007195 ! adenylate cyclase-inhibiting dopamine receptor signaling pathway
relationship: negatively_regulates GO:0007195 ! adenylate cyclase-inhibiting dopamine receptor signaling pathway
created_by: kmv
creation_date: 2016-02-29T22:42:25Z

[Term]
id: GO:1904992
name: positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of adenylate cyclase-inhibiting dopamine receptor signaling pathway." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:26554819]
synonym: "activation of adenylate cyclase-inhibiting dopamine receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of dopamine receptor, adenylate cyclase inhibiting pathway" NARROW [GOC:TermGenie]
synonym: "activation of dopamine receptor, adenylyl cyclase inhibiting pathway" NARROW [GOC:TermGenie]
synonym: "activation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "activation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of dopamine receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of dopamine receptor, adenylyl cyclase inhibiting pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "positive regulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of dopamine receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of dopamine receptor, adenylyl cyclase inhibiting pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "up regulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of dopamine receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of dopamine receptor, adenylyl cyclase inhibiting pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "up-regulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of dopamine receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of dopamine receptor, adenylyl cyclase inhibiting pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:TermGenie]
synonym: "upregulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0060161 ! positive regulation of dopamine receptor signaling pathway
is_a: GO:1904990 ! regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007195 ! adenylate cyclase-inhibiting dopamine receptor signaling pathway
relationship: positively_regulates GO:0007195 ! adenylate cyclase-inhibiting dopamine receptor signaling pathway
created_by: kmv
creation_date: 2016-02-29T22:42:33Z

[Term]
id: GO:1904993
name: obsolete positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in positive regulation of G2/M transition of mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any positive regulation of cyclin-dependent protein serine/threonine kinase activity that is involved in positive regulation of G2/M transition of mitotic cell cycle." [GO_REF:0000060, GOC:TermGenie, PMID:24728197]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "activation of cyclin-dependent protein kinase activity involved in positive regulation of G2/M transition of mitotic cell cycle" NARROW [GOC:TermGenie]
synonym: "activation of cyclin-dependent protein kinase activity involved in positive regulation of mitotic entry" NARROW [GOC:TermGenie]
synonym: "positive regulation of CDK activity involved in positive regulation of G2/M transition of mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "positive regulation of CDK activity involved in positive regulation of mitotic entry" EXACT [GOC:TermGenie]
synonym: "positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in positive regulation of mitotic entry" EXACT [GOC:TermGenie]
synonym: "stimulation of cyclin-dependent protein kinase activity involved in positive regulation of G2/M transition of mitotic cell cycle" NARROW [GOC:TermGenie]
synonym: "stimulation of cyclin-dependent protein kinase activity involved in positive regulation of mitotic entry" NARROW [GOC:TermGenie]
synonym: "up regulation of cyclin-dependent protein kinase activity involved in positive regulation of G2/M transition of mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "up regulation of cyclin-dependent protein kinase activity involved in positive regulation of mitotic entry" EXACT [GOC:TermGenie]
synonym: "up-regulation of cyclin-dependent protein kinase activity involved in positive regulation of G2/M transition of mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "up-regulation of cyclin-dependent protein kinase activity involved in positive regulation of mitotic entry" EXACT [GOC:TermGenie]
synonym: "upregulation of cyclin-dependent protein kinase activity involved in positive regulation of G2/M transition of mitotic cell cycle" EXACT [GOC:TermGenie]
synonym: "upregulation of cyclin-dependent protein kinase activity involved in positive regulation of mitotic entry" EXACT [GOC:TermGenie]
is_obsolete: true
created_by: al
creation_date: 2016-03-01T00:59:41Z

[Term]
id: GO:1904994
name: regulation of leukocyte adhesion to vascular endothelial cell
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of leukocyte adhesion to vascular endothelial cell." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23897866]
is_a: GO:1903037 ! regulation of leukocyte cell-cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061756 ! leukocyte adhesion to vascular endothelial cell
relationship: regulates GO:0061756 ! leukocyte adhesion to vascular endothelial cell
created_by: bc
creation_date: 2016-03-01T10:59:00Z

[Term]
id: GO:1904995
name: negative regulation of leukocyte adhesion to vascular endothelial cell
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte adhesion to vascular endothelial cell." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23897866]
synonym: "down regulation of leukocyte adhesion to vascular endothelial cell" EXACT [GOC:TermGenie]
synonym: "down-regulation of leukocyte adhesion to vascular endothelial cell" EXACT [GOC:TermGenie]
synonym: "downregulation of leukocyte adhesion to vascular endothelial cell" EXACT [GOC:TermGenie]
synonym: "inhibition of leukocyte adhesion to vascular endothelial cell" NARROW [GOC:TermGenie]
is_a: GO:1903038 ! negative regulation of leukocyte cell-cell adhesion
is_a: GO:1904994 ! regulation of leukocyte adhesion to vascular endothelial cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061756 ! leukocyte adhesion to vascular endothelial cell
relationship: negatively_regulates GO:0061756 ! leukocyte adhesion to vascular endothelial cell
created_by: bc
creation_date: 2016-03-01T10:59:08Z

[Term]
id: GO:1904996
name: positive regulation of leukocyte adhesion to vascular endothelial cell
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of leukocyte adhesion to vascular endothelial cell." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23897866]
synonym: "activation of leukocyte adhesion to vascular endothelial cell" NARROW [GOC:TermGenie]
synonym: "up regulation of leukocyte adhesion to vascular endothelial cell" EXACT [GOC:TermGenie]
synonym: "up-regulation of leukocyte adhesion to vascular endothelial cell" EXACT [GOC:TermGenie]
synonym: "upregulation of leukocyte adhesion to vascular endothelial cell" EXACT [GOC:TermGenie]
is_a: GO:1903039 ! positive regulation of leukocyte cell-cell adhesion
is_a: GO:1904994 ! regulation of leukocyte adhesion to vascular endothelial cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061756 ! leukocyte adhesion to vascular endothelial cell
relationship: positively_regulates GO:0061756 ! leukocyte adhesion to vascular endothelial cell
created_by: bc
creation_date: 2016-03-01T10:59:22Z

[Term]
id: GO:1904997
name: regulation of leukocyte adhesion to arterial endothelial cell
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of leukocyte adhesion to arterial endothelial cell." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22267480]
is_a: GO:1904994 ! regulation of leukocyte adhesion to vascular endothelial cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061757 ! leukocyte adhesion to arterial endothelial cell
relationship: regulates GO:0061757 ! leukocyte adhesion to arterial endothelial cell
created_by: bc
creation_date: 2016-03-01T11:04:49Z

[Term]
id: GO:1904998
name: negative regulation of leukocyte adhesion to arterial endothelial cell
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte adhesion to arterial endothelial cell." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22267480]
synonym: "down regulation of leukocyte adhesion to arterial endothelial cell" EXACT [GOC:TermGenie]
synonym: "down-regulation of leukocyte adhesion to arterial endothelial cell" EXACT [GOC:TermGenie]
synonym: "downregulation of leukocyte adhesion to arterial endothelial cell" EXACT [GOC:TermGenie]
synonym: "inhibition of leukocyte adhesion to arterial endothelial cell" NARROW [GOC:TermGenie]
is_a: GO:1904995 ! negative regulation of leukocyte adhesion to vascular endothelial cell
is_a: GO:1904997 ! regulation of leukocyte adhesion to arterial endothelial cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061757 ! leukocyte adhesion to arterial endothelial cell
relationship: negatively_regulates GO:0061757 ! leukocyte adhesion to arterial endothelial cell
created_by: bc
creation_date: 2016-03-01T11:04:57Z

[Term]
id: GO:1904999
name: positive regulation of leukocyte adhesion to arterial endothelial cell
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of leukocyte adhesion to arterial endothelial cell." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22267480]
synonym: "activation of leukocyte adhesion to arterial endothelial cell" NARROW [GOC:TermGenie]
synonym: "up regulation of leukocyte adhesion to arterial endothelial cell" EXACT [GOC:TermGenie]
synonym: "up-regulation of leukocyte adhesion to arterial endothelial cell" EXACT [GOC:TermGenie]
synonym: "upregulation of leukocyte adhesion to arterial endothelial cell" EXACT [GOC:TermGenie]
is_a: GO:1904996 ! positive regulation of leukocyte adhesion to vascular endothelial cell
is_a: GO:1904997 ! regulation of leukocyte adhesion to arterial endothelial cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061757 ! leukocyte adhesion to arterial endothelial cell
relationship: positively_regulates GO:0061757 ! leukocyte adhesion to arterial endothelial cell
created_by: bc
creation_date: 2016-03-01T11:05:05Z

[Term]
id: GO:1905000
name: regulation of membrane repolarization during atrial cardiac muscle cell action potential
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of membrane repolarization during atrial cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:21098446]
synonym: "regulation of atrial repolarization" RELATED [GOC:TermGenie]
synonym: "regulation of electrocardiogram QRS complex" RELATED [GOC:TermGenie]
is_a: GO:0060372 ! regulation of atrial cardiac muscle cell membrane repolarization
is_a: GO:0098910 ! regulation of atrial cardiac muscle cell action potential
is_a: GO:1905031 ! regulation of membrane repolarization during cardiac muscle cell action potential
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0098914 ! membrane repolarization during atrial cardiac muscle cell action potential
relationship: regulates GO:0098914 ! membrane repolarization during atrial cardiac muscle cell action potential
created_by: rph
creation_date: 2016-03-01T13:28:05Z

[Term]
id: GO:1905001
name: negative regulation of membrane repolarization during atrial cardiac muscle cell action potential
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of membrane repolarization during atrial cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:21098446]
synonym: "down regulation of atrial repolarization" RELATED [GOC:TermGenie]
synonym: "down regulation of electrocardiogram QRS complex" RELATED [GOC:TermGenie]
synonym: "down regulation of membrane repolarization during atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "down-regulation of atrial repolarization" RELATED [GOC:TermGenie]
synonym: "down-regulation of electrocardiogram QRS complex" RELATED [GOC:TermGenie]
synonym: "down-regulation of membrane repolarization during atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "downregulation of atrial repolarization" RELATED [GOC:TermGenie]
synonym: "downregulation of electrocardiogram QRS complex" RELATED [GOC:TermGenie]
synonym: "downregulation of membrane repolarization during atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "inhibition of atrial repolarization" RELATED [GOC:TermGenie]
synonym: "inhibition of electrocardiogram QRS complex" RELATED [GOC:TermGenie]
synonym: "inhibition of membrane repolarization during atrial cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "negative regulation of atrial repolarization" RELATED [GOC:TermGenie]
synonym: "negative regulation of electrocardiogram QRS complex" RELATED [GOC:TermGenie]
is_a: GO:1903948 ! negative regulation of atrial cardiac muscle cell action potential
is_a: GO:1905000 ! regulation of membrane repolarization during atrial cardiac muscle cell action potential
is_a: GO:1905032 ! negative regulation of membrane repolarization during cardiac muscle cell action potential
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0098914 ! membrane repolarization during atrial cardiac muscle cell action potential
relationship: negatively_regulates GO:0098914 ! membrane repolarization during atrial cardiac muscle cell action potential
created_by: rph
creation_date: 2016-03-01T13:28:13Z

[Term]
id: GO:1905002
name: positive regulation of membrane repolarization during atrial cardiac muscle cell action potential
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of membrane repolarization during atrial cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:21098446]
synonym: "activation of atrial repolarization" RELATED [GOC:TermGenie]
synonym: "activation of electrocardiogram QRS complex" RELATED [GOC:TermGenie]
synonym: "activation of membrane repolarization during atrial cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "positive regulation of atrial repolarization" RELATED [GOC:TermGenie]
synonym: "positive regulation of electrocardiogram QRS complex" RELATED [GOC:TermGenie]
synonym: "up regulation of atrial repolarization" RELATED [GOC:TermGenie]
synonym: "up regulation of electrocardiogram QRS complex" RELATED [GOC:TermGenie]
synonym: "up regulation of membrane repolarization during atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up-regulation of atrial repolarization" RELATED [GOC:TermGenie]
synonym: "up-regulation of electrocardiogram QRS complex" RELATED [GOC:TermGenie]
synonym: "up-regulation of membrane repolarization during atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "upregulation of atrial repolarization" RELATED [GOC:TermGenie]
synonym: "upregulation of electrocardiogram QRS complex" RELATED [GOC:TermGenie]
synonym: "upregulation of membrane repolarization during atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie]
is_a: GO:1903949 ! positive regulation of atrial cardiac muscle cell action potential
is_a: GO:1905000 ! regulation of membrane repolarization during atrial cardiac muscle cell action potential
is_a: GO:1905033 ! positive regulation of membrane repolarization during cardiac muscle cell action potential
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0098914 ! membrane repolarization during atrial cardiac muscle cell action potential
relationship: positively_regulates GO:0098914 ! membrane repolarization during atrial cardiac muscle cell action potential
created_by: rph
creation_date: 2016-03-01T13:28:21Z

[Term]
id: GO:1905003
name: picolinic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving picolinic acid." [GO_REF:0000068, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19843166]
synonym: "picolinate metabolism" EXACT [CHEBI:38184]
synonym: "picolinic acid metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0072524 ! pyridine-containing compound metabolic process
created_by: bf
creation_date: 2016-03-01T14:06:28Z

[Term]
id: GO:1905004
name: picolinic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of picolinic acid." [GO_REF:0000068, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19843166]
synonym: "picolinate biosynthesis" EXACT [CHEBI:38184]
synonym: "picolinate biosynthetic process" EXACT [CHEBI:38184]
synonym: "picolinic acid anabolism" EXACT [GOC:TermGenie]
synonym: "picolinic acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "picolinic acid formation" EXACT [GOC:TermGenie]
synonym: "picolinic acid synthesis" EXACT [GOC:TermGenie]
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:0072525 ! pyridine-containing compound biosynthetic process
is_a: GO:1905003 ! picolinic acid metabolic process
created_by: bf
creation_date: 2016-03-01T14:06:35Z

[Term]
id: GO:1905005
name: regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of epithelial to mesenchymal transition involved in endocardial cushion formation." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461]
is_a: GO:0010717 ! regulation of epithelial to mesenchymal transition
is_a: GO:2000826 ! regulation of heart morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003198 ! epithelial to mesenchymal transition involved in endocardial cushion formation
relationship: regulates GO:0003198 ! epithelial to mesenchymal transition involved in endocardial cushion formation
created_by: rl
creation_date: 2016-03-01T15:38:39Z

[Term]
id: GO:1905006
name: negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial to mesenchymal transition involved in endocardial cushion formation." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461]
synonym: "down regulation of epithelial to mesenchymal transition involved in endocardial cushion formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of epithelial to mesenchymal transition involved in endocardial cushion formation" EXACT [GOC:TermGenie]
synonym: "downregulation of epithelial to mesenchymal transition involved in endocardial cushion formation" EXACT [GOC:TermGenie]
synonym: "inhibition of epithelial to mesenchymal transition involved in endocardial cushion formation" NARROW [GOC:TermGenie]
is_a: GO:0010719 ! negative regulation of epithelial to mesenchymal transition
is_a: GO:1905005 ! regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003198 ! epithelial to mesenchymal transition involved in endocardial cushion formation
relationship: negatively_regulates GO:0003198 ! epithelial to mesenchymal transition involved in endocardial cushion formation
created_by: rl
creation_date: 2016-03-01T15:38:47Z

[Term]
id: GO:1905007
name: positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of epithelial to mesenchymal transition involved in endocardial cushion formation." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461]
synonym: "activation of epithelial to mesenchymal transition involved in endocardial cushion formation" NARROW [GOC:TermGenie]
synonym: "up regulation of epithelial to mesenchymal transition involved in endocardial cushion formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of epithelial to mesenchymal transition involved in endocardial cushion formation" EXACT [GOC:TermGenie]
synonym: "upregulation of epithelial to mesenchymal transition involved in endocardial cushion formation" EXACT [GOC:TermGenie]
is_a: GO:0010718 ! positive regulation of epithelial to mesenchymal transition
is_a: GO:1905005 ! regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003198 ! epithelial to mesenchymal transition involved in endocardial cushion formation
relationship: positively_regulates GO:0003198 ! epithelial to mesenchymal transition involved in endocardial cushion formation
created_by: rl
creation_date: 2016-03-01T15:38:54Z

[Term]
id: GO:1905008
name: regulation of L-lysine import into cell
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of L-lysine import into cell." [GO_REF:0000058, GOC:TermGenie, PMID:7499219]
is_a: GO:0010805 ! regulation of lysine import
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1903410 ! L-lysine import into cell
relationship: regulates GO:1903410 ! L-lysine import into cell
created_by: sl
creation_date: 2016-03-02T00:15:49Z

[Term]
id: GO:1905009
name: negative regulation of L-lysine import into cell
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of L-lysine import into cell." [GO_REF:0000058, GOC:TermGenie, PMID:7499219]
synonym: "down regulation of L-lysine import into cell" EXACT [GOC:TermGenie]
synonym: "down-regulation of L-lysine import into cell" EXACT [GOC:TermGenie]
synonym: "downregulation of L-lysine import into cell" EXACT [GOC:TermGenie]
synonym: "inhibition of L-lysine import into cell" NARROW [GOC:TermGenie]
is_a: GO:0010806 ! negative regulation of lysine import
is_a: GO:1905008 ! regulation of L-lysine import into cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1903410 ! L-lysine import into cell
relationship: negatively_regulates GO:1903410 ! L-lysine import into cell
created_by: sl
creation_date: 2016-03-02T00:15:57Z

[Term]
id: GO:1905010
name: positive regulation of L-lysine import into cell
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of L-lysine import into cell." [GO_REF:0000058, GOC:TermGenie, PMID:7499219]
synonym: "activation of L-lysine import into cell" NARROW [GOC:TermGenie]
synonym: "up regulation of L-lysine import into cell" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-lysine import into cell" EXACT [GOC:TermGenie]
synonym: "upregulation of L-lysine import into cell" EXACT [GOC:TermGenie]
is_a: GO:0051957 ! positive regulation of amino acid transport
is_a: GO:1905008 ! regulation of L-lysine import into cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1903410 ! L-lysine import into cell
relationship: positively_regulates GO:1903410 ! L-lysine import into cell
created_by: sl
creation_date: 2016-03-02T00:16:04Z

[Term]
id: GO:1905011
name: transmembrane phosphate ion transport from cytosol to vacuole
namespace: biological_process
def: "The directed movement of phosphate ions across a membrane from the cytosol into a vacuole." [GO_REF:0000078, GOC:TermGenie, PMID:26554016]
is_a: GO:0007034 ! vacuolar transport
is_a: GO:0035435 ! phosphate ion transmembrane transport
created_by: tb
creation_date: 2016-03-03T00:34:12Z

[Term]
id: GO:1905012
name: regulation of 'de novo' NAD biosynthetic process from tryptophan
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of 'de novo' NAD biosynthetic process from tryptophan." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:12140278, PMID:19843166]
synonym: "regulation of de novo NAD biosynthetic process from tryptophan" RELATED [GOC:TermGenie]
is_a: GO:0030808 ! regulation of nucleotide biosynthetic process
is_a: GO:0090357 ! regulation of tryptophan metabolic process
is_a: GO:1902688 ! regulation of NAD metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034354 ! 'de novo' NAD biosynthetic process from tryptophan
relationship: regulates GO:0034354 ! 'de novo' NAD biosynthetic process from tryptophan
created_by: bf
creation_date: 2016-03-03T10:00:50Z

[Term]
id: GO:1905013
name: negative regulation of 'de novo' NAD biosynthetic process from tryptophan
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of 'de novo' NAD biosynthetic process from tryptophan." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:12140278, PMID:19843166]
synonym: "down regulation of 'de novo' NAD biosynthetic process from tryptophan" EXACT [GOC:TermGenie]
synonym: "down regulation of de novo NAD biosynthetic process from tryptophan" RELATED [GOC:TermGenie]
synonym: "down-regulation of 'de novo' NAD biosynthetic process from tryptophan" EXACT [GOC:TermGenie]
synonym: "down-regulation of de novo NAD biosynthetic process from tryptophan" RELATED [GOC:TermGenie]
synonym: "downregulation of 'de novo' NAD biosynthetic process from tryptophan" EXACT [GOC:TermGenie]
synonym: "downregulation of de novo NAD biosynthetic process from tryptophan" RELATED [GOC:TermGenie]
synonym: "inhibition of 'de novo' NAD biosynthetic process from tryptophan" NARROW [GOC:TermGenie]
synonym: "inhibition of de novo NAD biosynthetic process from tryptophan" RELATED [GOC:TermGenie]
synonym: "negative regulation of de novo NAD biosynthetic process from tryptophan" RELATED [GOC:TermGenie]
is_a: GO:0030809 ! negative regulation of nucleotide biosynthetic process
is_a: GO:0045763 ! negative regulation of cellular amino acid metabolic process
is_a: GO:1902689 ! negative regulation of NAD metabolic process
is_a: GO:1905012 ! regulation of 'de novo' NAD biosynthetic process from tryptophan
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034354 ! 'de novo' NAD biosynthetic process from tryptophan
relationship: negatively_regulates GO:0034354 ! 'de novo' NAD biosynthetic process from tryptophan
created_by: bf
creation_date: 2016-03-03T10:01:00Z

[Term]
id: GO:1905014
name: positive regulation of 'de novo' NAD biosynthetic process from tryptophan
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of 'de novo' NAD biosynthetic process from tryptophan." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "activation of 'de novo' NAD biosynthetic process from tryptophan" NARROW [GOC:TermGenie]
synonym: "activation of de novo NAD biosynthetic process from tryptophan" RELATED [GOC:TermGenie]
synonym: "positive regulation of de novo NAD biosynthetic process from tryptophan" RELATED [GOC:TermGenie]
synonym: "up regulation of 'de novo' NAD biosynthetic process from tryptophan" EXACT [GOC:TermGenie]
synonym: "up regulation of de novo NAD biosynthetic process from tryptophan" RELATED [GOC:TermGenie]
synonym: "up-regulation of 'de novo' NAD biosynthetic process from tryptophan" EXACT [GOC:TermGenie]
synonym: "up-regulation of de novo NAD biosynthetic process from tryptophan" RELATED [GOC:TermGenie]
synonym: "upregulation of 'de novo' NAD biosynthetic process from tryptophan" EXACT [GOC:TermGenie]
synonym: "upregulation of de novo NAD biosynthetic process from tryptophan" RELATED [GOC:TermGenie]
is_a: GO:0030810 ! positive regulation of nucleotide biosynthetic process
is_a: GO:0090358 ! positive regulation of tryptophan metabolic process
is_a: GO:1902690 ! positive regulation of NAD metabolic process
is_a: GO:1905012 ! regulation of 'de novo' NAD biosynthetic process from tryptophan
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034354 ! 'de novo' NAD biosynthetic process from tryptophan
relationship: positively_regulates GO:0034354 ! 'de novo' NAD biosynthetic process from tryptophan
created_by: bf
creation_date: 2016-03-03T10:01:10Z

[Term]
id: GO:1905015
name: regulation of isoleucine-tRNA ligase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of isoleucine-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:1665486]
synonym: "regulation of isoleucine translase activity" EXACT [GOC:TermGenie]
synonym: "regulation of isoleucine-transfer RNA ligase activity" EXACT [GOC:TermGenie]
synonym: "regulation of isoleucine-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of isoleucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of isoleucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of isoleucyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of L-isoleucine:tRNAIle ligase (AMP-forming)" EXACT [GOC:TermGenie]
is_a: GO:1903630 ! regulation of aminoacyl-tRNA ligase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004822 ! isoleucine-tRNA ligase activity
relationship: regulates GO:0004822 ! isoleucine-tRNA ligase activity
created_by: sl
creation_date: 2016-03-03T19:00:48Z

[Term]
id: GO:1905016
name: negative regulation of isoleucine-tRNA ligase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of isoleucine-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:1665486]
synonym: "down regulation of isoleucine translase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of isoleucine-transfer RNA ligase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of isoleucine-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of isoleucine-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of isoleucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of isoleucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of isoleucyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of L-isoleucine:tRNAIle ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "down-regulation of isoleucine translase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of isoleucine-transfer RNA ligase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of isoleucine-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of isoleucine-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of isoleucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of isoleucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of isoleucyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of L-isoleucine:tRNAIle ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "downregulation of isoleucine translase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of isoleucine-transfer RNA ligase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of isoleucine-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of isoleucine-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of isoleucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of isoleucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of isoleucyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of L-isoleucine:tRNAIle ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "inhibition of isoleucine translase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of isoleucine-transfer RNA ligase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of isoleucine-tRNA ligase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of isoleucine-tRNA synthetase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of isoleucyl-transfer ribonucleate synthetase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of isoleucyl-transfer RNA synthetase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of isoleucyl-tRNA synthetase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of L-isoleucine:tRNAIle ligase (AMP-forming)" NARROW [GOC:TermGenie]
synonym: "negative regulation of isoleucine translase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of isoleucine-transfer RNA ligase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of isoleucine-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of isoleucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of isoleucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of isoleucyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of L-isoleucine:tRNAIle ligase (AMP-forming)" EXACT [GOC:TermGenie]
is_a: GO:1903631 ! negative regulation of aminoacyl-tRNA ligase activity
is_a: GO:1905015 ! regulation of isoleucine-tRNA ligase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004822 ! isoleucine-tRNA ligase activity
relationship: negatively_regulates GO:0004822 ! isoleucine-tRNA ligase activity
created_by: sl
creation_date: 2016-03-03T19:00:57Z

[Term]
id: GO:1905017
name: positive regulation of isoleucine-tRNA ligase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of isoleucine-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:1665486]
synonym: "activation of isoleucine translase activity" NARROW [GOC:TermGenie]
synonym: "activation of isoleucine-transfer RNA ligase activity" NARROW [GOC:TermGenie]
synonym: "activation of isoleucine-tRNA ligase activity" NARROW [GOC:TermGenie]
synonym: "activation of isoleucine-tRNA synthetase activity" NARROW [GOC:TermGenie]
synonym: "activation of isoleucyl-transfer ribonucleate synthetase activity" NARROW [GOC:TermGenie]
synonym: "activation of isoleucyl-transfer RNA synthetase activity" NARROW [GOC:TermGenie]
synonym: "activation of isoleucyl-tRNA synthetase activity" NARROW [GOC:TermGenie]
synonym: "activation of L-isoleucine:tRNAIle ligase (AMP-forming)" NARROW [GOC:TermGenie]
synonym: "positive regulation of isoleucine translase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of isoleucine-transfer RNA ligase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of isoleucine-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of isoleucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of isoleucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of isoleucyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of L-isoleucine:tRNAIle ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "up regulation of isoleucine translase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of isoleucine-transfer RNA ligase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of isoleucine-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of isoleucine-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of isoleucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of isoleucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of isoleucyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of L-isoleucine:tRNAIle ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "up-regulation of isoleucine translase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of isoleucine-transfer RNA ligase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of isoleucine-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of isoleucine-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of isoleucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of isoleucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of isoleucyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-isoleucine:tRNAIle ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "upregulation of isoleucine translase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of isoleucine-transfer RNA ligase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of isoleucine-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of isoleucine-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of isoleucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of isoleucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of isoleucyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of L-isoleucine:tRNAIle ligase (AMP-forming)" EXACT [GOC:TermGenie]
is_a: GO:1903632 ! positive regulation of aminoacyl-tRNA ligase activity
is_a: GO:1905015 ! regulation of isoleucine-tRNA ligase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004822 ! isoleucine-tRNA ligase activity
relationship: positively_regulates GO:0004822 ! isoleucine-tRNA ligase activity
created_by: sl
creation_date: 2016-03-03T19:01:06Z

[Term]
id: GO:1905018
name: regulation of methionine-tRNA ligase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of methionine-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:1665486]
synonym: "regulation of L-methionine:tRNAMet ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "regulation of methionine translase activity" EXACT [GOC:TermGenie]
synonym: "regulation of methionyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of methionyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of methionyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of methionyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of MetRS activity" EXACT [GOC:TermGenie]
is_a: GO:1903630 ! regulation of aminoacyl-tRNA ligase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004825 ! methionine-tRNA ligase activity
relationship: regulates GO:0004825 ! methionine-tRNA ligase activity
created_by: sl
creation_date: 2016-03-03T19:02:39Z

[Term]
id: GO:1905019
name: negative regulation of methionine-tRNA ligase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of methionine-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:1665486]
synonym: "down regulation of L-methionine:tRNAMet ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "down regulation of methionine translase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of methionine-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of methionyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of methionyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of methionyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of methionyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of MetRS activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of L-methionine:tRNAMet ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "down-regulation of methionine translase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of methionine-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of methionyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of methionyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of methionyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of methionyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of MetRS activity" EXACT [GOC:TermGenie]
synonym: "downregulation of L-methionine:tRNAMet ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "downregulation of methionine translase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of methionine-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of methionyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of methionyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of methionyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of methionyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of MetRS activity" EXACT [GOC:TermGenie]
synonym: "inhibition of L-methionine:tRNAMet ligase (AMP-forming)" NARROW [GOC:TermGenie]
synonym: "inhibition of methionine translase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of methionine-tRNA ligase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of methionyl-transfer ribonucleate synthetase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of methionyl-transfer ribonucleic acid synthetase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of methionyl-transfer RNA synthetase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of methionyl-tRNA synthetase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of MetRS activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of L-methionine:tRNAMet ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "negative regulation of methionine translase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of methionyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of methionyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of methionyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of methionyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of MetRS activity" EXACT [GOC:TermGenie]
is_a: GO:1903631 ! negative regulation of aminoacyl-tRNA ligase activity
is_a: GO:1905018 ! regulation of methionine-tRNA ligase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004825 ! methionine-tRNA ligase activity
relationship: negatively_regulates GO:0004825 ! methionine-tRNA ligase activity
created_by: sl
creation_date: 2016-03-03T19:02:48Z

[Term]
id: GO:1905020
name: positive regulation of methionine-tRNA ligase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of methionine-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:1665486]
synonym: "activation of L-methionine:tRNAMet ligase (AMP-forming)" NARROW [GOC:TermGenie]
synonym: "activation of methionine translase activity" NARROW [GOC:TermGenie]
synonym: "activation of methionine-tRNA ligase activity" NARROW [GOC:TermGenie]
synonym: "activation of methionyl-transfer ribonucleate synthetase activity" NARROW [GOC:TermGenie]
synonym: "activation of methionyl-transfer ribonucleic acid synthetase activity" NARROW [GOC:TermGenie]
synonym: "activation of methionyl-transfer RNA synthetase activity" NARROW [GOC:TermGenie]
synonym: "activation of methionyl-tRNA synthetase activity" NARROW [GOC:TermGenie]
synonym: "activation of MetRS activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of L-methionine:tRNAMet ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "positive regulation of methionine translase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of methionyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of methionyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of methionyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of methionyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of MetRS activity" EXACT [GOC:TermGenie]
synonym: "up regulation of L-methionine:tRNAMet ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "up regulation of methionine translase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of methionine-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of methionyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of methionyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of methionyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of methionyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of MetRS activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-methionine:tRNAMet ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "up-regulation of methionine translase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of methionine-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of methionyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of methionyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of methionyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of methionyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of MetRS activity" EXACT [GOC:TermGenie]
synonym: "upregulation of L-methionine:tRNAMet ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "upregulation of methionine translase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of methionine-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of methionyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of methionyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of methionyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of methionyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of MetRS activity" EXACT [GOC:TermGenie]
is_a: GO:1903632 ! positive regulation of aminoacyl-tRNA ligase activity
is_a: GO:1905018 ! regulation of methionine-tRNA ligase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004825 ! methionine-tRNA ligase activity
relationship: positively_regulates GO:0004825 ! methionine-tRNA ligase activity
created_by: sl
creation_date: 2016-03-03T19:02:57Z

[Term]
id: GO:1905021
name: regulation of threonine-tRNA ligase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of threonine-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:8049265]
synonym: "regulation of L-threonine:tRNAThr ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "regulation of threonine translase activity" EXACT [GOC:TermGenie]
synonym: "regulation of threonine-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of threonyl ribonucleic synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of threonyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of threonyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of threonyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of threonyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "regulation of TRS" RELATED [GOC:TermGenie]
is_a: GO:1903630 ! regulation of aminoacyl-tRNA ligase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004829 ! threonine-tRNA ligase activity
relationship: regulates GO:0004829 ! threonine-tRNA ligase activity
created_by: sl
creation_date: 2016-03-03T19:12:23Z

[Term]
id: GO:1905022
name: negative regulation of threonine-tRNA ligase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of threonine-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:8049265]
synonym: "down regulation of L-threonine:tRNAThr ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "down regulation of threonine translase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of threonine-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of threonine-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of threonyl ribonucleic synthetase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of threonyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of threonyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of threonyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of threonyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of TRS" RELATED [GOC:TermGenie]
synonym: "down-regulation of L-threonine:tRNAThr ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "down-regulation of threonine translase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of threonine-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of threonine-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of threonyl ribonucleic synthetase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of threonyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of threonyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of threonyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of threonyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of TRS" RELATED [GOC:TermGenie]
synonym: "downregulation of L-threonine:tRNAThr ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "downregulation of threonine translase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of threonine-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of threonine-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of threonyl ribonucleic synthetase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of threonyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of threonyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of threonyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of threonyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of TRS" RELATED [GOC:TermGenie]
synonym: "inhibition of L-threonine:tRNAThr ligase (AMP-forming)" NARROW [GOC:TermGenie]
synonym: "inhibition of threonine translase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of threonine-transfer ribonucleate synthetase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of threonine-tRNA ligase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of threonyl ribonucleic synthetase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of threonyl-transfer ribonucleate synthetase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of threonyl-transfer ribonucleic acid synthetase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of threonyl-transfer RNA synthetase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of threonyl-tRNA synthetase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of TRS" RELATED [GOC:TermGenie]
synonym: "negative regulation of L-threonine:tRNAThr ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "negative regulation of threonine translase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of threonine-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of threonyl ribonucleic synthetase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of threonyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of threonyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of threonyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of threonyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of TRS" RELATED [GOC:TermGenie]
is_a: GO:1903631 ! negative regulation of aminoacyl-tRNA ligase activity
is_a: GO:1905021 ! regulation of threonine-tRNA ligase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004829 ! threonine-tRNA ligase activity
relationship: negatively_regulates GO:0004829 ! threonine-tRNA ligase activity
created_by: sl
creation_date: 2016-03-03T19:12:32Z

[Term]
id: GO:1905023
name: positive regulation of threonine-tRNA ligase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of threonine-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:8049265]
synonym: "activation of L-threonine:tRNAThr ligase (AMP-forming)" NARROW [GOC:TermGenie]
synonym: "activation of threonine translase activity" NARROW [GOC:TermGenie]
synonym: "activation of threonine-transfer ribonucleate synthetase activity" NARROW [GOC:TermGenie]
synonym: "activation of threonine-tRNA ligase activity" NARROW [GOC:TermGenie]
synonym: "activation of threonyl ribonucleic synthetase activity" NARROW [GOC:TermGenie]
synonym: "activation of threonyl-transfer ribonucleate synthetase activity" NARROW [GOC:TermGenie]
synonym: "activation of threonyl-transfer ribonucleic acid synthetase activity" NARROW [GOC:TermGenie]
synonym: "activation of threonyl-transfer RNA synthetase activity" NARROW [GOC:TermGenie]
synonym: "activation of threonyl-tRNA synthetase activity" NARROW [GOC:TermGenie]
synonym: "activation of TRS" RELATED [GOC:TermGenie]
synonym: "positive regulation of L-threonine:tRNAThr ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "positive regulation of threonine translase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of threonine-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of threonyl ribonucleic synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of threonyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of threonyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of threonyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of threonyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of TRS" RELATED [GOC:TermGenie]
synonym: "up regulation of L-threonine:tRNAThr ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "up regulation of threonine translase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of threonine-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of threonine-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of threonyl ribonucleic synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of threonyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of threonyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of threonyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of threonyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of TRS" RELATED [GOC:TermGenie]
synonym: "up-regulation of L-threonine:tRNAThr ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "up-regulation of threonine translase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of threonine-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of threonine-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of threonyl ribonucleic synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of threonyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of threonyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of threonyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of threonyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of TRS" RELATED [GOC:TermGenie]
synonym: "upregulation of L-threonine:tRNAThr ligase (AMP-forming)" EXACT [GOC:TermGenie]
synonym: "upregulation of threonine translase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of threonine-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of threonine-tRNA ligase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of threonyl ribonucleic synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of threonyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of threonyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of threonyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of threonyl-tRNA synthetase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of TRS" RELATED [GOC:TermGenie]
is_a: GO:1903632 ! positive regulation of aminoacyl-tRNA ligase activity
is_a: GO:1905021 ! regulation of threonine-tRNA ligase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004829 ! threonine-tRNA ligase activity
relationship: positively_regulates GO:0004829 ! threonine-tRNA ligase activity
created_by: sl
creation_date: 2016-03-03T19:12:41Z

[Term]
id: GO:1905024
name: regulation of membrane repolarization during ventricular cardiac muscle cell action potential
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of membrane repolarization during ventricular cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:19893015]
synonym: "regulation of electrocardiogram T wave" RELATED [GOC:TermGenie]
synonym: "regulation of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie]
synonym: "regulation of ventricular repolarization" RELATED [GOC:TermGenie]
is_a: GO:0060307 ! regulation of ventricular cardiac muscle cell membrane repolarization
is_a: GO:0098911 ! regulation of ventricular cardiac muscle cell action potential
is_a: GO:1905031 ! regulation of membrane repolarization during cardiac muscle cell action potential
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0098915 ! membrane repolarization during ventricular cardiac muscle cell action potential
relationship: regulates GO:0098915 ! membrane repolarization during ventricular cardiac muscle cell action potential
created_by: rph
creation_date: 2016-03-04T11:19:02Z

[Term]
id: GO:1905025
name: negative regulation of membrane repolarization during ventricular cardiac muscle cell action potential
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of membrane repolarization during ventricular cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:19893015]
synonym: "down regulation of electrocardiogram T wave" RELATED [GOC:TermGenie]
synonym: "down regulation of membrane repolarization during ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "down regulation of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie]
synonym: "down regulation of ventricular repolarization" RELATED [GOC:TermGenie]
synonym: "down-regulation of electrocardiogram T wave" RELATED [GOC:TermGenie]
synonym: "down-regulation of membrane repolarization during ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "down-regulation of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie]
synonym: "down-regulation of ventricular repolarization" RELATED [GOC:TermGenie]
synonym: "downregulation of electrocardiogram T wave" RELATED [GOC:TermGenie]
synonym: "downregulation of membrane repolarization during ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "downregulation of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie]
synonym: "downregulation of ventricular repolarization" RELATED [GOC:TermGenie]
synonym: "inhibition of electrocardiogram T wave" RELATED [GOC:TermGenie]
synonym: "inhibition of membrane repolarization during ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "inhibition of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie]
synonym: "inhibition of ventricular repolarization" RELATED [GOC:TermGenie]
synonym: "negative regulation of electrocardiogram T wave" RELATED [GOC:TermGenie]
synonym: "negative regulation of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie]
synonym: "negative regulation of ventricular repolarization" RELATED [GOC:TermGenie]
is_a: GO:1903946 ! negative regulation of ventricular cardiac muscle cell action potential
is_a: GO:1905024 ! regulation of membrane repolarization during ventricular cardiac muscle cell action potential
is_a: GO:1905032 ! negative regulation of membrane repolarization during cardiac muscle cell action potential
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0098915 ! membrane repolarization during ventricular cardiac muscle cell action potential
relationship: negatively_regulates GO:0098915 ! membrane repolarization during ventricular cardiac muscle cell action potential
created_by: rph
creation_date: 2016-03-04T11:19:12Z

[Term]
id: GO:1905026
name: positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of membrane repolarization during ventricular cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:19893015]
synonym: "activation of electrocardiogram T wave" RELATED [GOC:TermGenie]
synonym: "activation of membrane repolarization during ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "activation of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie]
synonym: "activation of ventricular repolarization" RELATED [GOC:TermGenie]
synonym: "positive regulation of electrocardiogram T wave" RELATED [GOC:TermGenie]
synonym: "positive regulation of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie]
synonym: "positive regulation of ventricular repolarization" RELATED [GOC:TermGenie]
synonym: "up regulation of electrocardiogram T wave" RELATED [GOC:TermGenie]
synonym: "up regulation of membrane repolarization during ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up regulation of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie]
synonym: "up regulation of ventricular repolarization" RELATED [GOC:TermGenie]
synonym: "up-regulation of electrocardiogram T wave" RELATED [GOC:TermGenie]
synonym: "up-regulation of membrane repolarization during ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up-regulation of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie]
synonym: "up-regulation of ventricular repolarization" RELATED [GOC:TermGenie]
synonym: "upregulation of electrocardiogram T wave" RELATED [GOC:TermGenie]
synonym: "upregulation of membrane repolarization during ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "upregulation of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie]
synonym: "upregulation of ventricular repolarization" RELATED [GOC:TermGenie]
is_a: GO:1903947 ! positive regulation of ventricular cardiac muscle cell action potential
is_a: GO:1905024 ! regulation of membrane repolarization during ventricular cardiac muscle cell action potential
is_a: GO:1905033 ! positive regulation of membrane repolarization during cardiac muscle cell action potential
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0098915 ! membrane repolarization during ventricular cardiac muscle cell action potential
relationship: positively_regulates GO:0098915 ! membrane repolarization during ventricular cardiac muscle cell action potential
created_by: rph
creation_date: 2016-03-04T11:19:21Z

[Term]
id: GO:1905027
name: regulation of membrane depolarization during AV node cell action potential
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of membrane depolarization during AV node cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:19726871]
synonym: "regulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "regulation of membrane depolarization during AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
is_a: GO:0098904 ! regulation of AV node cell action potential
is_a: GO:1900825 ! regulation of membrane depolarization during cardiac muscle cell action potential
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0086045 ! membrane depolarization during AV node cell action potential
relationship: regulates GO:0086045 ! membrane depolarization during AV node cell action potential
created_by: rph
creation_date: 2016-03-04T13:46:06Z

[Term]
id: GO:1905028
name: negative regulation of membrane depolarization during AV node cell action potential
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of membrane depolarization during AV node cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:19726871]
synonym: "down regulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "down regulation of membrane depolarization during AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "down regulation of membrane depolarization during AV node cell action potential" EXACT [GOC:TermGenie]
synonym: "down-regulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "down-regulation of membrane depolarization during AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "down-regulation of membrane depolarization during AV node cell action potential" EXACT [GOC:TermGenie]
synonym: "downregulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "downregulation of membrane depolarization during AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "downregulation of membrane depolarization during AV node cell action potential" EXACT [GOC:TermGenie]
synonym: "inhibition of membrane depolarization during atrioventricular node cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "inhibition of membrane depolarization during AV node cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "inhibition of membrane depolarization during AV node cell action potential" NARROW [GOC:TermGenie]
synonym: "negative regulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "negative regulation of membrane depolarization during AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
is_a: GO:1900826 ! negative regulation of membrane depolarization during cardiac muscle cell action potential
is_a: GO:1903950 ! negative regulation of AV node cell action potential
is_a: GO:1905027 ! regulation of membrane depolarization during AV node cell action potential
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0086045 ! membrane depolarization during AV node cell action potential
relationship: negatively_regulates GO:0086045 ! membrane depolarization during AV node cell action potential
created_by: rph
creation_date: 2016-03-04T13:46:15Z

[Term]
id: GO:1905029
name: positive regulation of membrane depolarization during AV node cell action potential
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of membrane depolarization during AV node cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:19726871]
synonym: "activation of membrane depolarization during atrioventricular node cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "activation of membrane depolarization during AV node cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "activation of membrane depolarization during AV node cell action potential" NARROW [GOC:TermGenie]
synonym: "positive regulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "positive regulation of membrane depolarization during AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up regulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up regulation of membrane depolarization during AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up regulation of membrane depolarization during AV node cell action potential" EXACT [GOC:TermGenie]
synonym: "up-regulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up-regulation of membrane depolarization during AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up-regulation of membrane depolarization during AV node cell action potential" EXACT [GOC:TermGenie]
synonym: "upregulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "upregulation of membrane depolarization during AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "upregulation of membrane depolarization during AV node cell action potential" EXACT [GOC:TermGenie]
is_a: GO:1900827 ! positive regulation of membrane depolarization during cardiac muscle cell action potential
is_a: GO:1903951 ! positive regulation of AV node cell action potential
is_a: GO:1905027 ! regulation of membrane depolarization during AV node cell action potential
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0086045 ! membrane depolarization during AV node cell action potential
relationship: positively_regulates GO:0086045 ! membrane depolarization during AV node cell action potential
created_by: rph
creation_date: 2016-03-04T13:46:24Z

[Term]
id: GO:1905030
name: voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential
namespace: molecular_function
def: "Any voltage-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, ISBN:9780071120005]
synonym: "voltage gated ion channel activity involved in regulation of post-synaptic membrane potential" EXACT [GOC:TermGenie]
synonym: "voltage gated ion channel activity involved in regulation of postsynaptic membrane potential" EXACT [GOC:TermGenie]
synonym: "voltage-dependent ion channel activity involved in regulation of post-synaptic membrane potential" EXACT [GOC:TermGenie]
synonym: "voltage-dependent ion channel activity involved in regulation of postsynaptic membrane potential" EXACT [GOC:TermGenie]
synonym: "voltage-gated ion channel activity involved in regulation of post-synaptic membrane potential" EXACT [GOC:TermGenie]
is_a: GO:0005244 ! voltage-gated ion channel activity
intersection_of: GO:0005244 ! voltage-gated ion channel activity
intersection_of: part_of GO:0060078 ! regulation of postsynaptic membrane potential
relationship: part_of GO:0060078 ! regulation of postsynaptic membrane potential
created_by: dos
creation_date: 2016-03-04T15:51:54Z

[Term]
id: GO:1905031
name: regulation of membrane repolarization during cardiac muscle cell action potential
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of membrane repolarization during cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:23157812]
is_a: GO:0098901 ! regulation of cardiac muscle cell action potential
is_a: GO:0098903 ! regulation of membrane repolarization during action potential
is_a: GO:0099623 ! regulation of cardiac muscle cell membrane repolarization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0086013 ! membrane repolarization during cardiac muscle cell action potential
relationship: regulates GO:0086013 ! membrane repolarization during cardiac muscle cell action potential
created_by: rph
creation_date: 2016-03-07T10:24:34Z

[Term]
id: GO:1905032
name: negative regulation of membrane repolarization during cardiac muscle cell action potential
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of membrane repolarization during cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:23157812]
synonym: "down regulation of membrane repolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "down-regulation of membrane repolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "downregulation of membrane repolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "inhibition of membrane repolarization during cardiac muscle cell action potential" NARROW [GOC:TermGenie]
is_a: GO:0034766 ! negative regulation of ion transmembrane transport
is_a: GO:0045759 ! negative regulation of action potential
is_a: GO:1905031 ! regulation of membrane repolarization during cardiac muscle cell action potential
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0086013 ! membrane repolarization during cardiac muscle cell action potential
relationship: negatively_regulates GO:0086013 ! membrane repolarization during cardiac muscle cell action potential
created_by: rph
creation_date: 2016-03-07T10:24:44Z

[Term]
id: GO:1905033
name: positive regulation of membrane repolarization during cardiac muscle cell action potential
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of membrane repolarization during cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:23157812]
synonym: "activation of membrane repolarization during cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "up regulation of membrane repolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up-regulation of membrane repolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "upregulation of membrane repolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie]
is_a: GO:0034767 ! positive regulation of ion transmembrane transport
is_a: GO:0045760 ! positive regulation of action potential
is_a: GO:1905031 ! regulation of membrane repolarization during cardiac muscle cell action potential
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0086013 ! membrane repolarization during cardiac muscle cell action potential
relationship: positively_regulates GO:0086013 ! membrane repolarization during cardiac muscle cell action potential
created_by: rph
creation_date: 2016-03-07T10:24:53Z

[Term]
id: GO:1905034
name: regulation of antifungal innate immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of an antifungal innate immune response." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:22470487]
is_a: GO:0045088 ! regulation of innate immune response
is_a: GO:1900150 ! regulation of defense response to fungus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061760 ! antifungal innate immune response
relationship: regulates GO:0061760 ! antifungal innate immune response
created_by: dph
creation_date: 2016-03-07T20:07:54Z

[Term]
id: GO:1905035
name: negative regulation of antifungal innate immune response
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of an antifungal innate immune response." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:22470487]
synonym: "down regulation of antifungal innate immune response" EXACT [GOC:TermGenie]
synonym: "down-regulation of antifungal innate immune response" EXACT [GOC:TermGenie]
synonym: "downregulation of antifungal innate immune response" EXACT [GOC:TermGenie]
synonym: "inhibition of antifungal innate immune response" NARROW [GOC:TermGenie]
is_a: GO:0002832 ! negative regulation of response to biotic stimulus
is_a: GO:0032102 ! negative regulation of response to external stimulus
is_a: GO:0043901 ! negative regulation of multi-organism process
is_a: GO:0045824 ! negative regulation of innate immune response
is_a: GO:1905034 ! regulation of antifungal innate immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061760 ! antifungal innate immune response
relationship: negatively_regulates GO:0061760 ! antifungal innate immune response
created_by: dph
creation_date: 2016-03-07T20:08:05Z

[Term]
id: GO:1905036
name: positive regulation of antifungal innate immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of an antifungal innate immune response." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:22470487]
synonym: "activation of antifungal innate immune response" NARROW [GOC:TermGenie]
synonym: "up regulation of antifungal innate immune response" EXACT [GOC:TermGenie]
synonym: "up-regulation of antifungal innate immune response" EXACT [GOC:TermGenie]
synonym: "upregulation of antifungal innate immune response" EXACT [GOC:TermGenie]
is_a: GO:0002833 ! positive regulation of response to biotic stimulus
is_a: GO:0032103 ! positive regulation of response to external stimulus
is_a: GO:0043902 ! positive regulation of multi-organism process
is_a: GO:0045089 ! positive regulation of innate immune response
is_a: GO:1905034 ! regulation of antifungal innate immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061760 ! antifungal innate immune response
relationship: positively_regulates GO:0061760 ! antifungal innate immune response
created_by: dph
creation_date: 2016-03-07T20:08:26Z

[Term]
id: GO:1905037
name: autophagosome organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an autophagosome." [GO_REF:000103, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22186024]
synonym: "autophagic vacuole organization" EXACT [GOC:TermGenie]
synonym: "initial autophagic vacuole organization" RELATED [GOC:TermGenie]
is_a: GO:0007033 ! vacuole organization
relationship: part_of GO:0016236 ! macroautophagy
created_by: bf
creation_date: 2016-03-08T14:18:10Z

[Term]
id: GO:1905038
name: regulation of membrane lipid metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of membrane lipid metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:25954280]
synonym: "regulation of membrane lipid metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019216 ! regulation of lipid metabolic process
is_a: GO:0031323 ! regulation of cellular metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006643 ! membrane lipid metabolic process
relationship: regulates GO:0006643 ! membrane lipid metabolic process
created_by: tb
creation_date: 2016-03-08T20:41:32Z

[Term]
id: GO:1905039
name: carboxylic acid transmembrane transport
namespace: biological_process
def: "The directed movement of carboxylic acid across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:10869563]
is_a: GO:0046942 ! carboxylic acid transport
is_a: GO:0098656 ! anion transmembrane transport
is_a: GO:1903825 ! organic acid transmembrane transport
created_by: vw
creation_date: 2016-03-09T15:33:53Z

[Term]
id: GO:1905040
name: otic placode development
namespace: biological_process
def: "The process whose specific outcome is the progression of an otic placode over time, from its formation to the mature structure." [GO_REF:0000094, GOC:bf, GOC:mat, GOC:PARL, GOC:TermGenie, PMID:18356247]
synonym: "auditory placode development" RELATED [GOC:TermGenie]
synonym: "ear placode development" RELATED [GOC:TermGenie]
synonym: "ear/otic placode development" RELATED [GOC:TermGenie]
synonym: "octaval placode development" RELATED [GOC:TermGenie]
synonym: "octaval VIII placode development" RELATED [GOC:TermGenie]
synonym: "placoda otica development" EXACT [GOC:TermGenie]
is_a: GO:0071696 ! ectodermal placode development
created_by: bf
creation_date: 2016-03-10T09:30:20Z

[Term]
id: GO:1905041
name: regulation of epithelium regeneration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of epithelium regeneration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23221517]
synonym: "regulation of regeneration of epithelium" EXACT [GOC:TermGenie]
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:0061041 ! regulation of wound healing
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990399 ! epithelium regeneration
relationship: regulates GO:1990399 ! epithelium regeneration
created_by: rph
creation_date: 2016-03-11T10:58:53Z

[Term]
id: GO:1905042
name: negative regulation of epithelium regeneration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of epithelium regeneration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23221517]
synonym: "down regulation of epithelium regeneration" EXACT [GOC:TermGenie]
synonym: "down regulation of regeneration of epithelium" EXACT [GOC:TermGenie]
synonym: "down-regulation of epithelium regeneration" EXACT [GOC:TermGenie]
synonym: "down-regulation of regeneration of epithelium" EXACT [GOC:TermGenie]
synonym: "downregulation of epithelium regeneration" EXACT [GOC:TermGenie]
synonym: "downregulation of regeneration of epithelium" EXACT [GOC:TermGenie]
synonym: "inhibition of epithelium regeneration" NARROW [GOC:TermGenie]
synonym: "inhibition of regeneration of epithelium" NARROW [GOC:TermGenie]
synonym: "negative regulation of regeneration of epithelium" EXACT [GOC:TermGenie]
is_a: GO:0048640 ! negative regulation of developmental growth
is_a: GO:0061045 ! negative regulation of wound healing
is_a: GO:1905041 ! regulation of epithelium regeneration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990399 ! epithelium regeneration
relationship: negatively_regulates GO:1990399 ! epithelium regeneration
created_by: rph
creation_date: 2016-03-11T10:59:03Z

[Term]
id: GO:1905043
name: positive regulation of epithelium regeneration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of epithelium regeneration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23221517]
synonym: "activation of epithelium regeneration" NARROW [GOC:TermGenie]
synonym: "activation of regeneration of epithelium" NARROW [GOC:TermGenie]
synonym: "positive regulation of regeneration of epithelium" EXACT [GOC:TermGenie]
synonym: "up regulation of epithelium regeneration" EXACT [GOC:TermGenie]
synonym: "up regulation of regeneration of epithelium" EXACT [GOC:TermGenie]
synonym: "up-regulation of epithelium regeneration" EXACT [GOC:TermGenie]
synonym: "up-regulation of regeneration of epithelium" EXACT [GOC:TermGenie]
synonym: "upregulation of epithelium regeneration" EXACT [GOC:TermGenie]
synonym: "upregulation of regeneration of epithelium" EXACT [GOC:TermGenie]
is_a: GO:0048639 ! positive regulation of developmental growth
is_a: GO:0090303 ! positive regulation of wound healing
is_a: GO:1905041 ! regulation of epithelium regeneration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990399 ! epithelium regeneration
relationship: positively_regulates GO:1990399 ! epithelium regeneration
created_by: rph
creation_date: 2016-03-11T10:59:12Z

[Term]
id: GO:1905044
name: regulation of Schwann cell proliferation involved in axon regeneration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Schwann cell proliferation involved in axon regeneration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22393241]
is_a: GO:0010624 ! regulation of Schwann cell proliferation
is_a: GO:0048679 ! regulation of axon regeneration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0014011 ! Schwann cell proliferation involved in axon regeneration
relationship: regulates GO:0014011 ! Schwann cell proliferation involved in axon regeneration
created_by: rph
creation_date: 2016-03-11T14:47:35Z

[Term]
id: GO:1905045
name: negative regulation of Schwann cell proliferation involved in axon regeneration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of Schwann cell proliferation involved in axon regeneration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22393241]
synonym: "down regulation of Schwann cell proliferation involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "down-regulation of Schwann cell proliferation involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "downregulation of Schwann cell proliferation involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "inhibition of Schwann cell proliferation involved in axon regeneration" NARROW [GOC:TermGenie]
is_a: GO:0010626 ! negative regulation of Schwann cell proliferation
is_a: GO:0048681 ! negative regulation of axon regeneration
is_a: GO:1905044 ! regulation of Schwann cell proliferation involved in axon regeneration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0014011 ! Schwann cell proliferation involved in axon regeneration
relationship: negatively_regulates GO:0014011 ! Schwann cell proliferation involved in axon regeneration
created_by: rph
creation_date: 2016-03-11T14:47:45Z

[Term]
id: GO:1905046
name: positive regulation of Schwann cell proliferation involved in axon regeneration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of Schwann cell proliferation involved in axon regeneration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22393241]
synonym: "activation of Schwann cell proliferation involved in axon regeneration" NARROW [GOC:TermGenie]
synonym: "up regulation of Schwann cell proliferation involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "up-regulation of Schwann cell proliferation involved in axon regeneration" EXACT [GOC:TermGenie]
synonym: "upregulation of Schwann cell proliferation involved in axon regeneration" EXACT [GOC:TermGenie]
is_a: GO:0010625 ! positive regulation of Schwann cell proliferation
is_a: GO:0048680 ! positive regulation of axon regeneration
is_a: GO:1905044 ! regulation of Schwann cell proliferation involved in axon regeneration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0014011 ! Schwann cell proliferation involved in axon regeneration
relationship: positively_regulates GO:0014011 ! Schwann cell proliferation involved in axon regeneration
created_by: rph
creation_date: 2016-03-11T14:47:54Z

[Term]
id: GO:1905047
name: mitotic spindle pole body organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitotic spindle pole body." [GO_REF:000103, GOC:TermGenie, PMID:24963130]
is_a: GO:0051300 ! spindle pole body organization
created_by: vw
creation_date: 2016-03-14T09:48:42Z

[Term]
id: GO:1905048
name: regulation of metallopeptidase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of metallopeptidase activity." [GO_REF:0000059, GOC:TermGenie, PMID:26473732]
synonym: "regulation of metalloprotease activity" NARROW [GOC:TermGenie]
synonym: "regulation of metalloproteinase activity" NARROW [GOC:TermGenie]
is_a: GO:0052547 ! regulation of peptidase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008237 ! metallopeptidase activity
relationship: regulates GO:0008237 ! metallopeptidase activity
created_by: mm2
creation_date: 2016-03-15T16:44:27Z

[Term]
id: GO:1905049
name: negative regulation of metallopeptidase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of metallopeptidase activity." [GO_REF:0000059, GOC:TermGenie, PMID:26473732]
synonym: "down regulation of metallopeptidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of metalloprotease activity" NARROW [GOC:TermGenie]
synonym: "down regulation of metalloproteinase activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of metallopeptidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of metalloprotease activity" NARROW [GOC:TermGenie]
synonym: "down-regulation of metalloproteinase activity" NARROW [GOC:TermGenie]
synonym: "downregulation of metallopeptidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of metalloprotease activity" NARROW [GOC:TermGenie]
synonym: "downregulation of metalloproteinase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of metallopeptidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of metalloprotease activity" NARROW [GOC:TermGenie]
synonym: "inhibition of metalloproteinase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of metalloprotease activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of metalloproteinase activity" NARROW [GOC:TermGenie]
is_a: GO:0010466 ! negative regulation of peptidase activity
is_a: GO:1905048 ! regulation of metallopeptidase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008237 ! metallopeptidase activity
relationship: negatively_regulates GO:0008237 ! metallopeptidase activity
created_by: mm2
creation_date: 2016-03-15T16:44:37Z

[Term]
id: GO:1905050
name: positive regulation of metallopeptidase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of metallopeptidase activity." [GO_REF:0000059, GOC:TermGenie, PMID:26473732]
synonym: "activation of metallopeptidase activity" NARROW [GOC:TermGenie]
synonym: "activation of metalloprotease activity" NARROW [GOC:TermGenie]
synonym: "activation of metalloproteinase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of metalloprotease activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of metalloproteinase activity" NARROW [GOC:TermGenie]
synonym: "up regulation of metallopeptidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of metalloprotease activity" NARROW [GOC:TermGenie]
synonym: "up regulation of metalloproteinase activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of metallopeptidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of metalloprotease activity" NARROW [GOC:TermGenie]
synonym: "up-regulation of metalloproteinase activity" NARROW [GOC:TermGenie]
synonym: "upregulation of metallopeptidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of metalloprotease activity" NARROW [GOC:TermGenie]
synonym: "upregulation of metalloproteinase activity" NARROW [GOC:TermGenie]
is_a: GO:0010952 ! positive regulation of peptidase activity
is_a: GO:1905048 ! regulation of metallopeptidase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008237 ! metallopeptidase activity
relationship: positively_regulates GO:0008237 ! metallopeptidase activity
created_by: mm2
creation_date: 2016-03-15T16:44:46Z

[Term]
id: GO:1905051
name: regulation of base-excision repair
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of base-excision repair." [GO_REF:0000058, GOC:ah, GOC:TermGenie, PMID:18973764]
synonym: "regulation of BER" EXACT [GOC:TermGenie]
is_a: GO:0006282 ! regulation of DNA repair
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006284 ! base-excision repair
relationship: regulates GO:0006284 ! base-excision repair
created_by: ah
creation_date: 2016-03-16T10:52:00Z

[Term]
id: GO:1905052
name: negative regulation of base-excision repair
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of base-excision repair." [GO_REF:0000058, GOC:ah, GOC:TermGenie, PMID:18973764]
synonym: "down regulation of base-excision repair" EXACT [GOC:TermGenie]
synonym: "down regulation of BER" EXACT [GOC:TermGenie]
synonym: "down-regulation of base-excision repair" EXACT [GOC:TermGenie]
synonym: "down-regulation of BER" EXACT [GOC:TermGenie]
synonym: "downregulation of base-excision repair" EXACT [GOC:TermGenie]
synonym: "downregulation of BER" EXACT [GOC:TermGenie]
synonym: "inhibition of base-excision repair" NARROW [GOC:TermGenie]
synonym: "inhibition of BER" NARROW [GOC:TermGenie]
synonym: "negative regulation of BER" EXACT [GOC:TermGenie]
is_a: GO:0045738 ! negative regulation of DNA repair
is_a: GO:1905051 ! regulation of base-excision repair
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006284 ! base-excision repair
relationship: negatively_regulates GO:0006284 ! base-excision repair
created_by: ah
creation_date: 2016-03-16T10:52:09Z

[Term]
id: GO:1905053
name: positive regulation of base-excision repair
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of base-excision repair." [GO_REF:0000058, GOC:ah, GOC:TermGenie, PMID:18973764]
synonym: "activation of base-excision repair" NARROW [GOC:TermGenie]
synonym: "activation of BER" NARROW [GOC:TermGenie]
synonym: "positive regulation of BER" EXACT [GOC:TermGenie]
synonym: "up regulation of base-excision repair" EXACT [GOC:TermGenie]
synonym: "up regulation of BER" EXACT [GOC:TermGenie]
synonym: "up-regulation of base-excision repair" EXACT [GOC:TermGenie]
synonym: "up-regulation of BER" EXACT [GOC:TermGenie]
synonym: "upregulation of base-excision repair" EXACT [GOC:TermGenie]
synonym: "upregulation of BER" EXACT [GOC:TermGenie]
is_a: GO:0045739 ! positive regulation of DNA repair
is_a: GO:1905051 ! regulation of base-excision repair
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006284 ! base-excision repair
relationship: positively_regulates GO:0006284 ! base-excision repair
created_by: ah
creation_date: 2016-03-16T10:52:18Z

[Term]
id: GO:1905054
name: calcium-induced calcium release activity involved in regulation of presynaptic cytosolic calcium ion concentration
namespace: molecular_function
def: "Any calcium-induced calcium release activity that is involved in regulation of presynaptic cytosolic calcium ion concentration." [GO_REF:0000061, GOC:TermGenie, PMID:15919193]
subset: goslim_synapse
is_a: GO:0048763 ! calcium-induced calcium release activity
intersection_of: GO:0048763 ! calcium-induced calcium release activity
intersection_of: part_of GO:0099509 ! regulation of presynaptic cytosolic calcium ion concentration
relationship: part_of GO:0099509 ! regulation of presynaptic cytosolic calcium ion concentration
created_by: dos
creation_date: 2016-03-17T12:12:53Z

[Term]
id: GO:1905055
name: calcium:cation antiporter activity involved in regulation of presynaptic cytosolic calcium ion concentration
namespace: molecular_function
def: "Any calcium:cation antiporter activity that is involved in regulation of presynaptic cytosolic calcium ion concentration." [GO_REF:0000061, GOC:TermGenie, PMID:22972962, PMID:23255722]
subset: goslim_synapse
is_a: GO:0015368 ! calcium:cation antiporter activity
intersection_of: GO:0015368 ! calcium:cation antiporter activity
intersection_of: part_of GO:0099509 ! regulation of presynaptic cytosolic calcium ion concentration
relationship: part_of GO:0099509 ! regulation of presynaptic cytosolic calcium ion concentration
created_by: dos
creation_date: 2016-03-17T14:35:35Z

[Term]
id: GO:1905056
name: calcium-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration
namespace: molecular_function
def: "Any calcium-transporting ATPase activity that is involved in regulation of presynaptic cytosolic calcium ion concentration." [GO_REF:0000061, GOC:TermGenie, PMID:22972962]
subset: goslim_synapse
synonym: "ATP phosphohydrolase (Ca2+-transporting) involved in regulation of presynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie]
synonym: "Ca(2+)-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie]
synonym: "Ca2+-pumping ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie]
synonym: "Ca2+-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie]
synonym: "calcium ABC transporter involved in regulation of presynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie]
synonym: "calcium efflux ATPase involved in regulation of presynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie]
synonym: "calcium transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie]
synonym: "calcium-translocating P-type ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie]
synonym: "plasma membrane Ca-ATPase involved in regulation of presynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie]
is_a: GO:0005388 ! calcium-transporting ATPase activity
intersection_of: GO:0005388 ! calcium-transporting ATPase activity
intersection_of: part_of GO:0099509 ! regulation of presynaptic cytosolic calcium ion concentration
relationship: part_of GO:0099509 ! regulation of presynaptic cytosolic calcium ion concentration
created_by: dos
creation_date: 2016-03-17T14:35:25Z

[Term]
id: GO:1905057
name: voltage-gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration
namespace: molecular_function
def: "Any voltage-gated calcium channel activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration." [GO_REF:0000061, GOC:TermGenie, PMID:20734177]
subset: goslim_synapse
synonym: "depolarization-activated voltage gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie]
synonym: "depolarization-activated voltage-gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie]
synonym: "depolarization-activated voltage-gated calcium channel involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie]
synonym: "dihydropyridine-sensitive calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie]
synonym: "voltage gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie]
synonym: "voltage-dependent calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie]
synonym: "voltage-gated calcium ion channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie]
synonym: "voltage-sensitive calcium channel involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie]
is_a: GO:0099511 ! voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels
intersection_of: GO:0005245 ! voltage-gated calcium channel activity
intersection_of: part_of GO:0099566 ! regulation of postsynaptic cytosolic calcium ion concentration
relationship: part_of GO:0099566 ! regulation of postsynaptic cytosolic calcium ion concentration
created_by: dos
creation_date: 2016-03-18T12:31:48Z

[Term]
id: GO:1905058
name: calcium-induced calcium release activity involved in regulation of postsynaptic cytosolic calcium ion concentration
namespace: molecular_function
def: "Any calcium-induced calcium release activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration." [GO_REF:0000061, GOC:TermGenie, PMID:23639769]
subset: goslim_synapse
is_a: GO:0048763 ! calcium-induced calcium release activity
intersection_of: GO:0048763 ! calcium-induced calcium release activity
intersection_of: part_of GO:0099566 ! regulation of postsynaptic cytosolic calcium ion concentration
relationship: part_of GO:0099566 ! regulation of postsynaptic cytosolic calcium ion concentration
created_by: dos
creation_date: 2016-03-18T12:31:59Z

[Term]
id: GO:1905059
name: calcium-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration
namespace: molecular_function
def: "Any calcium-transporting ATPase activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration." [GO_REF:0000061, GOC:TermGenie, PMID:20678993]
subset: goslim_synapse
synonym: "ATP phosphohydrolase (Ca2+-transporting) involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie]
synonym: "Ca(2+)-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie]
synonym: "Ca2+-pumping ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie]
synonym: "Ca2+-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie]
synonym: "calcium ABC transporter involved in regulation of postsynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie]
synonym: "calcium efflux ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie]
synonym: "calcium transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie]
synonym: "calcium-translocating P-type ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie]
synonym: "plasma membrane Ca-ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie]
synonym: "sarco(endo)plasmic reticulum Ca2+-ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie]
synonym: "sarcoplasmic reticulum ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie]
is_a: GO:0005388 ! calcium-transporting ATPase activity
intersection_of: GO:0005388 ! calcium-transporting ATPase activity
intersection_of: part_of GO:0099566 ! regulation of postsynaptic cytosolic calcium ion concentration
relationship: part_of GO:0099566 ! regulation of postsynaptic cytosolic calcium ion concentration
created_by: dos
creation_date: 2016-03-18T12:32:08Z

[Term]
id: GO:1905060
name: calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration
namespace: molecular_function
def: "Any calcium:cation antiporter activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration." [GO_REF:0000061, GOC:TermGenie, PMID:18024055]
subset: goslim_synapse
is_a: GO:0015368 ! calcium:cation antiporter activity
intersection_of: GO:0015368 ! calcium:cation antiporter activity
intersection_of: part_of GO:0099566 ! regulation of postsynaptic cytosolic calcium ion concentration
relationship: part_of GO:0099566 ! regulation of postsynaptic cytosolic calcium ion concentration
created_by: dos
creation_date: 2016-03-18T12:32:17Z

[Term]
id: GO:1905061
name: negative regulation of cardioblast proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardioblast proliferation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:24236097]
synonym: "down regulation of cardioblast proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of cardioblast proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of cardioblast proliferation" EXACT [GOC:TermGenie]
synonym: "inhibition of cardioblast proliferation" NARROW [GOC:TermGenie]
is_a: GO:0003264 ! regulation of cardioblast proliferation
is_a: GO:2000137 ! negative regulation of cell proliferation involved in heart morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003263 ! cardioblast proliferation
relationship: negatively_regulates GO:0003263 ! cardioblast proliferation
created_by: bc
creation_date: 2016-03-21T11:00:13Z

[Term]
id: GO:1905062
name: positive regulation of cardioblast proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardioblast proliferation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:24236097]
synonym: "activation of cardioblast proliferation" NARROW [GOC:TermGenie]
synonym: "up regulation of cardioblast proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of cardioblast proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of cardioblast proliferation" EXACT [GOC:TermGenie]
is_a: GO:0003264 ! regulation of cardioblast proliferation
is_a: GO:2000138 ! positive regulation of cell proliferation involved in heart morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003263 ! cardioblast proliferation
relationship: positively_regulates GO:0003263 ! cardioblast proliferation
created_by: bc
creation_date: 2016-03-21T11:00:23Z

[Term]
id: GO:1905063
name: regulation of vascular smooth muscle cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vascular smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079]
synonym: "regulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "regulation of VSMC differentiation" EXACT [GOC:TermGenie]
is_a: GO:0051150 ! regulation of smooth muscle cell differentiation
is_a: GO:1901342 ! regulation of vasculature development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035886 ! vascular smooth muscle cell differentiation
relationship: regulates GO:0035886 ! vascular smooth muscle cell differentiation
created_by: rph
creation_date: 2016-03-21T11:14:53Z

[Term]
id: GO:1905064
name: negative regulation of vascular smooth muscle cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079]
synonym: "down regulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of VSMC differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of VSMC differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of VSMC differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of vascular associated smooth muscle cell differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of vascular smooth muscle cell differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of VSMC differentiation" NARROW [GOC:TermGenie]
synonym: "negative regulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "negative regulation of VSMC differentiation" EXACT [GOC:TermGenie]
is_a: GO:0051151 ! negative regulation of smooth muscle cell differentiation
is_a: GO:1901343 ! negative regulation of vasculature development
is_a: GO:1905063 ! regulation of vascular smooth muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035886 ! vascular smooth muscle cell differentiation
relationship: negatively_regulates GO:0035886 ! vascular smooth muscle cell differentiation
created_by: rph
creation_date: 2016-03-21T11:15:03Z

[Term]
id: GO:1905065
name: positive regulation of vascular smooth muscle cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079]
synonym: "activation of vascular associated smooth muscle cell differentiation" NARROW [GOC:TermGenie]
synonym: "activation of vascular smooth muscle cell differentiation" NARROW [GOC:TermGenie]
synonym: "activation of VSMC differentiation" NARROW [GOC:TermGenie]
synonym: "positive regulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of VSMC differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of VSMC differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of VSMC differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of VSMC differentiation" EXACT [GOC:TermGenie]
is_a: GO:0051152 ! positive regulation of smooth muscle cell differentiation
is_a: GO:1904018 ! positive regulation of vasculature development
is_a: GO:1905063 ! regulation of vascular smooth muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035886 ! vascular smooth muscle cell differentiation
relationship: positively_regulates GO:0035886 ! vascular smooth muscle cell differentiation
created_by: rph
creation_date: 2016-03-21T11:15:13Z

[Term]
id: GO:1905066
name: regulation of canonical Wnt signaling pathway involved in heart development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of canonical Wnt signaling pathway involved in heart development." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25034767]
synonym: "regulation of canonical Wnt receptor signaling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "regulation of canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "regulation of canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:TermGenie]
is_a: GO:0003307 ! regulation of Wnt signaling pathway involved in heart development
is_a: GO:0060828 ! regulation of canonical Wnt signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061316 ! canonical Wnt signaling pathway involved in heart development
relationship: regulates GO:0061316 ! canonical Wnt signaling pathway involved in heart development
created_by: bc
creation_date: 2016-03-21T12:46:56Z

[Term]
id: GO:1905067
name: negative regulation of canonical Wnt signaling pathway involved in heart development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of canonical Wnt signaling pathway involved in heart development." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25034767]
synonym: "down regulation of canonical Wnt receptor signaling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "down regulation of canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "down regulation of canonical Wnt signaling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "down regulation of canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "down-regulation of canonical Wnt receptor signaling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "down-regulation of canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "down-regulation of canonical Wnt signaling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "down-regulation of canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "downregulation of canonical Wnt receptor signaling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "downregulation of canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "downregulation of canonical Wnt signaling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "downregulation of canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "inhibition of canonical Wnt receptor signaling pathway involved in heart development" NARROW [GOC:TermGenie]
synonym: "inhibition of canonical Wnt receptor signalling pathway involved in heart development" NARROW [GOC:TermGenie]
synonym: "inhibition of canonical Wnt signaling pathway involved in heart development" NARROW [GOC:TermGenie]
synonym: "inhibition of canonical Wnt-activated signaling pathway involved in heart development" NARROW [GOC:TermGenie]
synonym: "negative regulation of canonical Wnt receptor signaling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "negative regulation of canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "negative regulation of canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:TermGenie]
is_a: GO:0003308 ! negative regulation of Wnt signaling pathway involved in heart development
is_a: GO:0090090 ! negative regulation of canonical Wnt signaling pathway
is_a: GO:1905066 ! regulation of canonical Wnt signaling pathway involved in heart development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061316 ! canonical Wnt signaling pathway involved in heart development
relationship: negatively_regulates GO:0061316 ! canonical Wnt signaling pathway involved in heart development
created_by: bc
creation_date: 2016-03-21T12:47:06Z

[Term]
id: GO:1905068
name: positive regulation of canonical Wnt signaling pathway involved in heart development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of canonical Wnt signaling pathway involved in heart development." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25034767]
synonym: "activation of canonical Wnt receptor signaling pathway involved in heart development" NARROW [GOC:TermGenie]
synonym: "activation of canonical Wnt receptor signalling pathway involved in heart development" NARROW [GOC:TermGenie]
synonym: "activation of canonical Wnt signaling pathway involved in heart development" NARROW [GOC:TermGenie]
synonym: "activation of canonical Wnt-activated signaling pathway involved in heart development" NARROW [GOC:TermGenie]
synonym: "positive regulation of canonical Wnt receptor signaling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "positive regulation of canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "positive regulation of canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "up regulation of canonical Wnt receptor signaling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "up regulation of canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "up regulation of canonical Wnt signaling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "up regulation of canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "up-regulation of canonical Wnt receptor signaling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "up-regulation of canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "up-regulation of canonical Wnt signaling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "up-regulation of canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "upregulation of canonical Wnt receptor signaling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "upregulation of canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "upregulation of canonical Wnt signaling pathway involved in heart development" EXACT [GOC:TermGenie]
synonym: "upregulation of canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0090263 ! positive regulation of canonical Wnt signaling pathway
is_a: GO:1905066 ! regulation of canonical Wnt signaling pathway involved in heart development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061316 ! canonical Wnt signaling pathway involved in heart development
relationship: positively_regulates GO:0061316 ! canonical Wnt signaling pathway involved in heart development
created_by: bc
creation_date: 2016-03-21T12:47:15Z

[Term]
id: GO:1905069
name: allantois development
namespace: biological_process
def: "The process whose specific outcome is the progression of an allantois over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, PMID:17440924, PMID:21470579]
synonym: "allantoic bud development" RELATED [GOC:TermGenie]
is_a: GO:1903867 ! extraembryonic membrane development
created_by: cls
creation_date: 2016-03-21T15:18:21Z

[Term]
id: GO:1905070
name: anterior visceral endoderm cell migration
namespace: biological_process
def: "The orderly movement of an anterior visceral endoderm cell from one site to another." [GO_REF:0000091, GOC:TermGenie, PMID:17078044]
is_a: GO:0016477 ! cell migration
created_by: cls
creation_date: 2016-03-21T15:18:32Z

[Term]
id: GO:1905071
name: occluding junction disassembly
namespace: biological_process
def: "The disaggregation of an occluding junction into its constituent components." [GO_REF:0000079, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461]
synonym: "occluding cell junction disassembly" EXACT [GOC:TermGenie]
synonym: "tight junction disassembly" RELATED []
is_a: GO:0022411 ! cellular component disassembly
is_a: GO:0045216 ! cell-cell junction organization
created_by: rl
creation_date: 2016-03-23T12:35:08Z

[Term]
id: GO:1905072
name: cardiac jelly development
namespace: biological_process
def: "The process whose specific outcome is the progression of cardiac jelly over time, from its formation to the mature structure." [GO_REF:0000094, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19703439]
synonym: "heart cardiac jelly development" EXACT [GOC:TermGenie]
is_a: GO:0009888 ! tissue development
created_by: rl
creation_date: 2016-03-23T13:17:59Z

[Term]
id: GO:1905073
name: regulation of occluding junction disassembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of occluding junction disassembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461]
synonym: "regulation of occluding cell junction disassembly" EXACT [GOC:TermGenie]
synonym: "regulation of tight junction disassembly" RELATED [GOC:TermGenie]
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1905071 ! occluding junction disassembly
relationship: regulates GO:1905071 ! occluding junction disassembly
created_by: rl
creation_date: 2016-03-23T19:32:51Z

[Term]
id: GO:1905074
name: negative regulation of occluding junction disassembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of occluding junction disassembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461]
synonym: "down regulation of occluding cell junction disassembly" EXACT [GOC:TermGenie]
synonym: "down regulation of occluding junction disassembly" EXACT [GOC:TermGenie]
synonym: "down regulation of tight junction disassembly" RELATED [GOC:TermGenie]
synonym: "down-regulation of occluding cell junction disassembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of occluding junction disassembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of tight junction disassembly" RELATED [GOC:TermGenie]
synonym: "downregulation of occluding cell junction disassembly" EXACT [GOC:TermGenie]
synonym: "downregulation of occluding junction disassembly" EXACT [GOC:TermGenie]
synonym: "downregulation of tight junction disassembly" RELATED [GOC:TermGenie]
synonym: "inhibition of occluding cell junction disassembly" NARROW [GOC:TermGenie]
synonym: "inhibition of occluding junction disassembly" NARROW [GOC:TermGenie]
synonym: "inhibition of tight junction disassembly" RELATED [GOC:TermGenie]
synonym: "negative regulation of occluding cell junction disassembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of tight junction disassembly" RELATED [GOC:TermGenie]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1905073 ! regulation of occluding junction disassembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1905071 ! occluding junction disassembly
relationship: negatively_regulates GO:1905071 ! occluding junction disassembly
created_by: rl
creation_date: 2016-03-23T19:33:01Z

[Term]
id: GO:1905075
name: positive regulation of occluding junction disassembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of occluding junction disassembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461]
synonym: "activation of occluding cell junction disassembly" NARROW [GOC:TermGenie]
synonym: "activation of occluding junction disassembly" NARROW [GOC:TermGenie]
synonym: "activation of tight junction disassembly" RELATED [GOC:TermGenie]
synonym: "positive regulation of occluding cell junction disassembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of tight junction disassembly" RELATED [GOC:TermGenie]
synonym: "up regulation of occluding cell junction disassembly" EXACT [GOC:TermGenie]
synonym: "up regulation of occluding junction disassembly" EXACT [GOC:TermGenie]
synonym: "up regulation of tight junction disassembly" RELATED [GOC:TermGenie]
synonym: "up-regulation of occluding cell junction disassembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of occluding junction disassembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of tight junction disassembly" RELATED [GOC:TermGenie]
synonym: "upregulation of occluding cell junction disassembly" EXACT [GOC:TermGenie]
synonym: "upregulation of occluding junction disassembly" EXACT [GOC:TermGenie]
synonym: "upregulation of tight junction disassembly" RELATED [GOC:TermGenie]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1905073 ! regulation of occluding junction disassembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1905071 ! occluding junction disassembly
relationship: positively_regulates GO:1905071 ! occluding junction disassembly
created_by: rl
creation_date: 2016-03-23T19:33:10Z

[Term]
id: GO:1905076
name: regulation of interleukin-17 secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of interleukin-17 secretion." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:16482511]
comment: An example of this is IL23A in human (Q9NPF7) in PMID:16482511  (inferred from direct assay).
synonym: "regulation of CTLA-8 secretion" EXACT [GOC:TermGenie]
synonym: "regulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion" EXACT [GOC:TermGenie]
synonym: "regulation of IL-17 secretion" EXACT [GOC:TermGenie]
synonym: "regulation of IL-17A secretion" EXACT [GOC:TermGenie]
synonym: "regulation of IL17A secretion" EXACT [GOC:TermGenie]
is_a: GO:0032660 ! regulation of interleukin-17 production
is_a: GO:0050707 ! regulation of cytokine secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072615 ! interleukin-17 secretion
relationship: regulates GO:0072615 ! interleukin-17 secretion
created_by: bhm
creation_date: 2016-03-24T15:44:21Z

[Term]
id: GO:1905077
name: negative regulation of interleukin-17 secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-17 secretion." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:16482511]
comment: An example of this is IL23A in human (Q9NPF7) in PMID:16482511  (inferred from direct assay).
synonym: "down regulation of CTLA-8 secretion" EXACT [GOC:TermGenie]
synonym: "down regulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion" EXACT [GOC:TermGenie]
synonym: "down regulation of IL-17 secretion" EXACT [GOC:TermGenie]
synonym: "down regulation of IL-17A secretion" EXACT [GOC:TermGenie]
synonym: "down regulation of IL17A secretion" EXACT [GOC:TermGenie]
synonym: "down regulation of interleukin-17 secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of CTLA-8 secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of IL-17 secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of IL-17A secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of IL17A secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of interleukin-17 secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of CTLA-8 secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of IL-17 secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of IL-17A secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of IL17A secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of interleukin-17 secretion" EXACT [GOC:TermGenie]
synonym: "inhibition of CTLA-8 secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of Cytotoxic T-lymphocyte-associated antigen 8 secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of IL-17 secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of IL-17A secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of IL17A secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of interleukin-17 secretion" NARROW [GOC:TermGenie]
synonym: "negative regulation of CTLA-8 secretion" EXACT [GOC:TermGenie]
synonym: "negative regulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion" EXACT [GOC:TermGenie]
synonym: "negative regulation of IL-17 secretion" EXACT [GOC:TermGenie]
synonym: "negative regulation of IL-17A secretion" EXACT [GOC:TermGenie]
synonym: "negative regulation of IL17A secretion" EXACT [GOC:TermGenie]
is_a: GO:0032700 ! negative regulation of interleukin-17 production
is_a: GO:0050710 ! negative regulation of cytokine secretion
is_a: GO:1905076 ! regulation of interleukin-17 secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072615 ! interleukin-17 secretion
relationship: negatively_regulates GO:0072615 ! interleukin-17 secretion
created_by: bhm
creation_date: 2016-03-24T15:44:31Z

[Term]
id: GO:1905078
name: positive regulation of interleukin-17 secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of interleukin-17 secretion." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:16482511]
comment: An example of this is IL23A in human (Q9NPF7) in PMID:16482511  (inferred from direct assay).
synonym: "activation of CTLA-8 secretion" NARROW [GOC:TermGenie]
synonym: "activation of Cytotoxic T-lymphocyte-associated antigen 8 secretion" NARROW [GOC:TermGenie]
synonym: "activation of IL-17 secretion" NARROW [GOC:TermGenie]
synonym: "activation of IL-17A secretion" NARROW [GOC:TermGenie]
synonym: "activation of IL17A secretion" NARROW [GOC:TermGenie]
synonym: "activation of interleukin-17 secretion" NARROW [GOC:TermGenie]
synonym: "positive regulation of CTLA-8 secretion" EXACT [GOC:TermGenie]
synonym: "positive regulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion" EXACT [GOC:TermGenie]
synonym: "positive regulation of IL-17 secretion" EXACT [GOC:TermGenie]
synonym: "positive regulation of IL-17A secretion" EXACT [GOC:TermGenie]
synonym: "positive regulation of IL17A secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of CTLA-8 secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of IL-17 secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of IL-17A secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of IL17A secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of interleukin-17 secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of CTLA-8 secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of IL-17 secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of IL-17A secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of IL17A secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of interleukin-17 secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of CTLA-8 secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of IL-17 secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of IL-17A secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of IL17A secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of interleukin-17 secretion" EXACT [GOC:TermGenie]
is_a: GO:0032740 ! positive regulation of interleukin-17 production
is_a: GO:0050715 ! positive regulation of cytokine secretion
is_a: GO:1905076 ! regulation of interleukin-17 secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072615 ! interleukin-17 secretion
relationship: positively_regulates GO:0072615 ! interleukin-17 secretion
created_by: bhm
creation_date: 2016-03-24T15:44:40Z

[Term]
id: GO:1905079
name: regulation of cerebellar neuron development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cerebellar neuron development." [GO_REF:0000058, GOC:TermGenie, PMID:26609159]
is_a: GO:0045664 ! regulation of neuron differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0098749 ! cerebellar neuron development
relationship: regulates GO:0098749 ! cerebellar neuron development
created_by: hjd
creation_date: 2016-03-24T19:45:17Z

[Term]
id: GO:1905080
name: negative regulation of cerebellar neuron development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cerebellar neuron development." [GO_REF:0000058, GOC:TermGenie, PMID:26609159]
synonym: "down regulation of cerebellar neuron development" EXACT [GOC:TermGenie]
synonym: "down-regulation of cerebellar neuron development" EXACT [GOC:TermGenie]
synonym: "downregulation of cerebellar neuron development" EXACT [GOC:TermGenie]
synonym: "inhibition of cerebellar neuron development" NARROW [GOC:TermGenie]
is_a: GO:0045665 ! negative regulation of neuron differentiation
is_a: GO:1905079 ! regulation of cerebellar neuron development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0098749 ! cerebellar neuron development
relationship: negatively_regulates GO:0098749 ! cerebellar neuron development
created_by: hjd
creation_date: 2016-03-24T19:45:26Z

[Term]
id: GO:1905081
name: positive regulation of cerebellar neuron development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cerebellar neuron development." [GO_REF:0000058, GOC:TermGenie, PMID:26609159]
synonym: "activation of cerebellar neuron development" NARROW [GOC:TermGenie]
synonym: "up regulation of cerebellar neuron development" EXACT [GOC:TermGenie]
synonym: "up-regulation of cerebellar neuron development" EXACT [GOC:TermGenie]
synonym: "upregulation of cerebellar neuron development" EXACT [GOC:TermGenie]
is_a: GO:0045666 ! positive regulation of neuron differentiation
is_a: GO:1905079 ! regulation of cerebellar neuron development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0098749 ! cerebellar neuron development
relationship: positively_regulates GO:0098749 ! cerebellar neuron development
created_by: hjd
creation_date: 2016-03-24T19:45:35Z

[Term]
id: GO:1905082
name: regulation of mitochondrial translational elongation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitochondrial translational elongation." [GO_REF:0000058, GOC:TermGenie, PMID:25738458]
synonym: "regulation of mitochondrial translation elongation" EXACT [GOC:TermGenie]
is_a: GO:0006448 ! regulation of translational elongation
is_a: GO:0070129 ! regulation of mitochondrial translation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070125 ! mitochondrial translational elongation
relationship: regulates GO:0070125 ! mitochondrial translational elongation
created_by: hjd
creation_date: 2016-03-25T17:37:03Z

[Term]
id: GO:1905083
name: negative regulation of mitochondrial translational elongation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial translational elongation." [GO_REF:0000058, GOC:TermGenie, PMID:25738458]
synonym: "down regulation of mitochondrial translation elongation" EXACT [GOC:TermGenie]
synonym: "down regulation of mitochondrial translational elongation" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitochondrial translation elongation" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitochondrial translational elongation" EXACT [GOC:TermGenie]
synonym: "downregulation of mitochondrial translation elongation" EXACT [GOC:TermGenie]
synonym: "downregulation of mitochondrial translational elongation" EXACT [GOC:TermGenie]
synonym: "inhibition of mitochondrial translation elongation" NARROW [GOC:TermGenie]
synonym: "inhibition of mitochondrial translational elongation" NARROW [GOC:TermGenie]
synonym: "negative regulation of mitochondrial translation elongation" EXACT [GOC:TermGenie]
is_a: GO:0045900 ! negative regulation of translational elongation
is_a: GO:0070130 ! negative regulation of mitochondrial translation
is_a: GO:1905082 ! regulation of mitochondrial translational elongation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070125 ! mitochondrial translational elongation
relationship: negatively_regulates GO:0070125 ! mitochondrial translational elongation
created_by: hjd
creation_date: 2016-03-25T17:37:13Z

[Term]
id: GO:1905084
name: positive regulation of mitochondrial translational elongation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitochondrial translational elongation." [GO_REF:0000058, GOC:TermGenie, PMID:25738458]
synonym: "activation of mitochondrial translation elongation" NARROW [GOC:TermGenie]
synonym: "activation of mitochondrial translational elongation" NARROW [GOC:TermGenie]
synonym: "positive regulation of mitochondrial translation elongation" EXACT [GOC:TermGenie]
synonym: "up regulation of mitochondrial translation elongation" EXACT [GOC:TermGenie]
synonym: "up regulation of mitochondrial translational elongation" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitochondrial translation elongation" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitochondrial translational elongation" EXACT [GOC:TermGenie]
synonym: "upregulation of mitochondrial translation elongation" EXACT [GOC:TermGenie]
synonym: "upregulation of mitochondrial translational elongation" EXACT [GOC:TermGenie]
is_a: GO:0045901 ! positive regulation of translational elongation
is_a: GO:0070131 ! positive regulation of mitochondrial translation
is_a: GO:1905082 ! regulation of mitochondrial translational elongation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070125 ! mitochondrial translational elongation
relationship: positively_regulates GO:0070125 ! mitochondrial translational elongation
created_by: hjd
creation_date: 2016-03-25T17:37:22Z

[Term]
id: GO:1905085
name: regulation of bioluminescence
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of bioluminescence." [GO_REF:0000058, GOC:rph, GOC:TermGenie, PMID:10913092]
is_a: GO:0031323 ! regulation of cellular metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008218 ! bioluminescence
relationship: regulates GO:0008218 ! bioluminescence
created_by: rph
creation_date: 2016-03-29T07:51:07Z

[Term]
id: GO:1905086
name: negative regulation of bioluminescence
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of bioluminescence." [GO_REF:0000058, GOC:rph, GOC:TermGenie, PMID:10913092]
synonym: "down regulation of bioluminescence" EXACT [GOC:TermGenie]
synonym: "down-regulation of bioluminescence" EXACT [GOC:TermGenie]
synonym: "downregulation of bioluminescence" EXACT [GOC:TermGenie]
synonym: "inhibition of bioluminescence" NARROW [GOC:TermGenie]
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:1905085 ! regulation of bioluminescence
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008218 ! bioluminescence
relationship: negatively_regulates GO:0008218 ! bioluminescence
created_by: rph
creation_date: 2016-03-29T07:51:17Z

[Term]
id: GO:1905087
name: positive regulation of bioluminescence
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of bioluminescence." [GO_REF:0000058, GOC:rph, GOC:TermGenie, PMID:10913092]
synonym: "activation of bioluminescence" NARROW [GOC:TermGenie]
synonym: "up regulation of bioluminescence" EXACT [GOC:TermGenie]
synonym: "up-regulation of bioluminescence" EXACT [GOC:TermGenie]
synonym: "upregulation of bioluminescence" EXACT [GOC:TermGenie]
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:1905085 ! regulation of bioluminescence
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008218 ! bioluminescence
relationship: positively_regulates GO:0008218 ! bioluminescence
created_by: rph
creation_date: 2016-03-29T07:51:27Z

[Term]
id: GO:1905088
name: positive regulation of synaptonemal complex assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of synaptonemal complex assembly." [GO_REF:0000058, GOC:TermGenie, PMID:24797370]
synonym: "activation of synaptonemal complex assembly" NARROW [GOC:TermGenie]
synonym: "activation of synaptonemal complex formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of synaptonemal complex formation" EXACT [GOC:TermGenie]
synonym: "up regulation of synaptonemal complex assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of synaptonemal complex formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of synaptonemal complex assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of synaptonemal complex formation" EXACT [GOC:TermGenie]
synonym: "upregulation of synaptonemal complex assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of synaptonemal complex formation" EXACT [GOC:TermGenie]
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:0051984 ! positive regulation of chromosome segregation
is_a: GO:0060903 ! positive regulation of meiosis I
is_a: GO:0090173 ! regulation of synaptonemal complex assembly
is_a: GO:2001252 ! positive regulation of chromosome organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007130 ! synaptonemal complex assembly
relationship: positively_regulates GO:0007130 ! synaptonemal complex assembly
created_by: mec
creation_date: 2016-03-30T08:39:03Z

[Term]
id: GO:1905089
name: regulation of parkin-mediated mitophagy in response to mitochondrial depolarization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of parkin-mediated mitophagy in response to mitochondrial depolarization." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:26942284]
is_a: GO:1904923 ! regulation of mitophagy in response to mitochondrial depolarization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061734 ! parkin-mediated mitophagy in response to mitochondrial depolarization
relationship: regulates GO:0061734 ! parkin-mediated mitophagy in response to mitochondrial depolarization
created_by: pad
creation_date: 2016-03-30T15:34:29Z

[Term]
id: GO:1905090
name: negative regulation of parkin-mediated mitophagy in response to mitochondrial depolarization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of parkin-mediated mitophagy in response to mitochondrial depolarization." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:26942284]
synonym: "down regulation of parkin-mediated mitophagy in response to mitochondrial depolarization" EXACT [GOC:TermGenie]
synonym: "down-regulation of parkin-mediated mitophagy in response to mitochondrial depolarization" EXACT [GOC:TermGenie]
synonym: "downregulation of parkin-mediated mitophagy in response to mitochondrial depolarization" EXACT [GOC:TermGenie]
synonym: "inhibition of parkin-mediated mitophagy in response to mitochondrial depolarization" NARROW [GOC:TermGenie]
is_a: GO:1904924 ! negative regulation of mitophagy in response to mitochondrial depolarization
is_a: GO:1905089 ! regulation of parkin-mediated mitophagy in response to mitochondrial depolarization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061734 ! parkin-mediated mitophagy in response to mitochondrial depolarization
relationship: negatively_regulates GO:0061734 ! parkin-mediated mitophagy in response to mitochondrial depolarization
created_by: pad
creation_date: 2016-03-30T15:34:38Z

[Term]
id: GO:1905091
name: positive regulation of parkin-mediated mitophagy in response to mitochondrial depolarization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of parkin-mediated mitophagy in response to mitochondrial depolarization." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:26942284]
synonym: "activation of parkin-mediated mitophagy in response to mitochondrial depolarization" NARROW [GOC:TermGenie]
synonym: "up regulation of parkin-mediated mitophagy in response to mitochondrial depolarization" EXACT [GOC:TermGenie]
synonym: "up-regulation of parkin-mediated mitophagy in response to mitochondrial depolarization" EXACT [GOC:TermGenie]
synonym: "upregulation of parkin-mediated mitophagy in response to mitochondrial depolarization" EXACT [GOC:TermGenie]
is_a: GO:1904925 ! positive regulation of mitophagy in response to mitochondrial depolarization
is_a: GO:1905089 ! regulation of parkin-mediated mitophagy in response to mitochondrial depolarization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061734 ! parkin-mediated mitophagy in response to mitochondrial depolarization
relationship: positively_regulates GO:0061734 ! parkin-mediated mitophagy in response to mitochondrial depolarization
created_by: pad
creation_date: 2016-03-30T15:34:47Z

[Term]
id: GO:1905092
name: response to diosgenin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diosgenin stimulus." [GO_REF:0000071, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25765596]
is_a: GO:0036314 ! response to sterol
created_by: bc
creation_date: 2016-03-31T11:04:28Z

[Term]
id: GO:1905093
name: cellular response to diosgenin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diosgenin stimulus." [GO_REF:0000071, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25765596]
is_a: GO:0036315 ! cellular response to sterol
is_a: GO:1905092 ! response to diosgenin
created_by: bc
creation_date: 2016-03-31T11:04:38Z

[Term]
id: GO:1905094
name: regulation of apolipoprotein A-I-mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of apolipoprotein A-I-mediated signaling pathway." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25084135]
synonym: "regulation of apolipoprotein A-I-mediated signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0009966 ! regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0038027 ! apolipoprotein A-I-mediated signaling pathway
relationship: regulates GO:0038027 ! apolipoprotein A-I-mediated signaling pathway
created_by: bc
creation_date: 2016-03-31T11:33:48Z

[Term]
id: GO:1905095
name: negative regulation of apolipoprotein A-I-mediated signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of apolipoprotein A-I-mediated signaling pathway." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25084135]
synonym: "down regulation of apolipoprotein A-I-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of apolipoprotein A-I-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of apolipoprotein A-I-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of apolipoprotein A-I-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of apolipoprotein A-I-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of apolipoprotein A-I-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of apolipoprotein A-I-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of apolipoprotein A-I-mediated signalling pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of apolipoprotein A-I-mediated signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:1905094 ! regulation of apolipoprotein A-I-mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0038027 ! apolipoprotein A-I-mediated signaling pathway
relationship: negatively_regulates GO:0038027 ! apolipoprotein A-I-mediated signaling pathway
created_by: bc
creation_date: 2016-03-31T11:33:58Z

[Term]
id: GO:1905096
name: positive regulation of apolipoprotein A-I-mediated signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of apolipoprotein A-I-mediated signaling pathway." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25084135]
synonym: "activation of apolipoprotein A-I-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of apolipoprotein A-I-mediated signalling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of apolipoprotein A-I-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of apolipoprotein A-I-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of apolipoprotein A-I-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of apolipoprotein A-I-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of apolipoprotein A-I-mediated signalling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of apolipoprotein A-I-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of apolipoprotein A-I-mediated signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:1905094 ! regulation of apolipoprotein A-I-mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0038027 ! apolipoprotein A-I-mediated signaling pathway
relationship: positively_regulates GO:0038027 ! apolipoprotein A-I-mediated signaling pathway
created_by: bc
creation_date: 2016-03-31T11:34:07Z

[Term]
id: GO:1905097
name: regulation of guanyl-nucleotide exchange factor activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of guanyl-nucleotide exchange factor activity." [GO_REF:0000059, GOC:TermGenie, PMID:20484009]
synonym: "regulation of GDP-dissociation stimulator activity" EXACT [GOC:TermGenie]
synonym: "regulation of GDS" EXACT [GOC:TermGenie]
synonym: "regulation of GEF" EXACT [GOC:TermGenie]
synonym: "regulation of GNRP" NARROW [GOC:TermGenie]
synonym: "regulation of guanyl-nucleotide release factor activity" EXACT [GOC:TermGenie]
synonym: "regulation of guanyl-nucleotide releasing factor" EXACT [GOC:TermGenie]
is_a: GO:0043087 ! regulation of GTPase activity
is_a: GO:0051098 ! regulation of binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0005085 ! guanyl-nucleotide exchange factor activity
relationship: regulates GO:0005085 ! guanyl-nucleotide exchange factor activity
created_by: sl
creation_date: 2016-03-31T16:09:35Z

[Term]
id: GO:1905098
name: negative regulation of guanyl-nucleotide exchange factor activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of guanyl-nucleotide exchange factor activity." [GO_REF:0000059, GOC:TermGenie, PMID:20484009]
synonym: "down regulation of GDP-dissociation stimulator activity" EXACT [GOC:TermGenie]
synonym: "down regulation of GDS" EXACT [GOC:TermGenie]
synonym: "down regulation of GEF" EXACT [GOC:TermGenie]
synonym: "down regulation of GNRP" NARROW [GOC:TermGenie]
synonym: "down regulation of guanyl-nucleotide exchange factor activity" EXACT [GOC:TermGenie]
synonym: "down regulation of guanyl-nucleotide release factor activity" EXACT [GOC:TermGenie]
synonym: "down regulation of guanyl-nucleotide releasing factor" EXACT [GOC:TermGenie]
synonym: "down-regulation of GDP-dissociation stimulator activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of GDS" EXACT [GOC:TermGenie]
synonym: "down-regulation of GEF" EXACT [GOC:TermGenie]
synonym: "down-regulation of GNRP" NARROW [GOC:TermGenie]
synonym: "down-regulation of guanyl-nucleotide exchange factor activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of guanyl-nucleotide release factor activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of guanyl-nucleotide releasing factor" EXACT [GOC:TermGenie]
synonym: "downregulation of GDP-dissociation stimulator activity" EXACT [GOC:TermGenie]
synonym: "downregulation of GDS" EXACT [GOC:TermGenie]
synonym: "downregulation of GEF" EXACT [GOC:TermGenie]
synonym: "downregulation of GNRP" NARROW [GOC:TermGenie]
synonym: "downregulation of guanyl-nucleotide exchange factor activity" EXACT [GOC:TermGenie]
synonym: "downregulation of guanyl-nucleotide release factor activity" EXACT [GOC:TermGenie]
synonym: "downregulation of guanyl-nucleotide releasing factor" EXACT [GOC:TermGenie]
synonym: "inhibition of GDP-dissociation stimulator activity" NARROW [GOC:TermGenie]
synonym: "inhibition of GDS" NARROW [GOC:TermGenie]
synonym: "inhibition of GEF" NARROW [GOC:TermGenie]
synonym: "inhibition of GNRP" NARROW [GOC:TermGenie]
synonym: "inhibition of guanyl-nucleotide exchange factor activity" NARROW [GOC:TermGenie]
synonym: "inhibition of guanyl-nucleotide release factor activity" NARROW [GOC:TermGenie]
synonym: "inhibition of guanyl-nucleotide releasing factor" NARROW [GOC:TermGenie]
synonym: "negative regulation of GDP-dissociation stimulator activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of GDS" EXACT [GOC:TermGenie]
synonym: "negative regulation of GEF" EXACT [GOC:TermGenie]
synonym: "negative regulation of GNRP" NARROW [GOC:TermGenie]
synonym: "negative regulation of guanyl-nucleotide release factor activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of guanyl-nucleotide releasing factor" EXACT [GOC:TermGenie]
is_a: GO:0044092 ! negative regulation of molecular function
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0051099 ! positive regulation of binding
is_a: GO:1905097 ! regulation of guanyl-nucleotide exchange factor activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0005085 ! guanyl-nucleotide exchange factor activity
relationship: negatively_regulates GO:0005085 ! guanyl-nucleotide exchange factor activity
created_by: sl
creation_date: 2016-03-31T16:09:45Z

[Term]
id: GO:1905099
name: positive regulation of guanyl-nucleotide exchange factor activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of guanyl-nucleotide exchange factor activity." [GO_REF:0000059, GOC:TermGenie, PMID:20484009]
synonym: "activation of GDP-dissociation stimulator activity" NARROW [GOC:TermGenie]
synonym: "activation of GDS" NARROW [GOC:TermGenie]
synonym: "activation of GEF" NARROW [GOC:TermGenie]
synonym: "activation of GNRP" NARROW [GOC:TermGenie]
synonym: "activation of guanyl-nucleotide exchange factor activity" NARROW [GOC:TermGenie]
synonym: "activation of guanyl-nucleotide release factor activity" NARROW [GOC:TermGenie]
synonym: "activation of guanyl-nucleotide releasing factor" NARROW [GOC:TermGenie]
synonym: "positive regulation of GDP-dissociation stimulator activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of GDS" EXACT [GOC:TermGenie]
synonym: "positive regulation of GEF" EXACT [GOC:TermGenie]
synonym: "positive regulation of GNRP" NARROW [GOC:TermGenie]
synonym: "positive regulation of guanyl-nucleotide release factor activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of guanyl-nucleotide releasing factor" EXACT [GOC:TermGenie]
synonym: "up regulation of GDP-dissociation stimulator activity" EXACT [GOC:TermGenie]
synonym: "up regulation of GDS" EXACT [GOC:TermGenie]
synonym: "up regulation of GEF" EXACT [GOC:TermGenie]
synonym: "up regulation of GNRP" NARROW [GOC:TermGenie]
synonym: "up regulation of guanyl-nucleotide exchange factor activity" EXACT [GOC:TermGenie]
synonym: "up regulation of guanyl-nucleotide release factor activity" EXACT [GOC:TermGenie]
synonym: "up regulation of guanyl-nucleotide releasing factor" EXACT [GOC:TermGenie]
synonym: "up-regulation of GDP-dissociation stimulator activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of GDS" EXACT [GOC:TermGenie]
synonym: "up-regulation of GEF" EXACT [GOC:TermGenie]
synonym: "up-regulation of GNRP" NARROW [GOC:TermGenie]
synonym: "up-regulation of guanyl-nucleotide exchange factor activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of guanyl-nucleotide release factor activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of guanyl-nucleotide releasing factor" EXACT [GOC:TermGenie]
synonym: "upregulation of GDP-dissociation stimulator activity" EXACT [GOC:TermGenie]
synonym: "upregulation of GDS" EXACT [GOC:TermGenie]
synonym: "upregulation of GEF" EXACT [GOC:TermGenie]
synonym: "upregulation of GNRP" NARROW [GOC:TermGenie]
synonym: "upregulation of guanyl-nucleotide exchange factor activity" EXACT [GOC:TermGenie]
synonym: "upregulation of guanyl-nucleotide release factor activity" EXACT [GOC:TermGenie]
synonym: "upregulation of guanyl-nucleotide releasing factor" EXACT [GOC:TermGenie]
is_a: GO:0044093 ! positive regulation of molecular function
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:1905097 ! regulation of guanyl-nucleotide exchange factor activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0005085 ! guanyl-nucleotide exchange factor activity
relationship: positively_regulates GO:0005085 ! guanyl-nucleotide exchange factor activity
created_by: sl
creation_date: 2016-03-31T16:09:54Z

[Term]
id: GO:1905100
name: regulation of apoptosome assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of apoptosome assembly." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:26265044]
synonym: "regulation of apoptosome formation" EXACT [GOC:TermGenie]
is_a: GO:0043254 ! regulation of protein complex assembly
is_a: GO:2001233 ! regulation of apoptotic signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097314 ! apoptosome assembly
relationship: regulates GO:0097314 ! apoptosome assembly
created_by: bc
creation_date: 2016-04-04T08:57:42Z

[Term]
id: GO:1905101
name: negative regulation of apoptosome assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptosome assembly." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:26265044]
synonym: "down regulation of apoptosome assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of apoptosome formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptosome assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptosome formation" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptosome assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptosome formation" EXACT [GOC:TermGenie]
synonym: "inhibition of apoptosome assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptosome formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptosome formation" EXACT [GOC:TermGenie]
is_a: GO:0031333 ! negative regulation of protein complex assembly
is_a: GO:1905100 ! regulation of apoptosome assembly
is_a: GO:2001234 ! negative regulation of apoptotic signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097314 ! apoptosome assembly
relationship: negatively_regulates GO:0097314 ! apoptosome assembly
created_by: bc
creation_date: 2016-04-04T08:57:51Z

[Term]
id: GO:1905102
name: positive regulation of apoptosome assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of apoptosome assembly." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:26265044]
synonym: "activation of apoptosome assembly" NARROW [GOC:TermGenie]
synonym: "activation of apoptosome formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptosome formation" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptosome assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptosome formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptosome assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptosome formation" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptosome assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptosome formation" EXACT [GOC:TermGenie]
is_a: GO:0031334 ! positive regulation of protein complex assembly
is_a: GO:1905100 ! regulation of apoptosome assembly
is_a: GO:2001235 ! positive regulation of apoptotic signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097314 ! apoptosome assembly
relationship: positively_regulates GO:0097314 ! apoptosome assembly
created_by: bc
creation_date: 2016-04-04T08:57:59Z

[Term]
id: GO:1905103
name: integral component of lysosomal membrane
namespace: cellular_component
def: "The component of the lysosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GO_REF:0000064, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:26134396]
synonym: "integral component of lysosome membrane" EXACT [GOC:bf]
synonym: "integral to lysosomal membrane" NARROW []
is_a: GO:0031166 ! integral component of vacuolar membrane
intersection_of: GO:0016021 ! integral component of membrane
intersection_of: part_of GO:0005765 ! lysosomal membrane
relationship: part_of GO:0005765 ! lysosomal membrane
created_by: bf
creation_date: 2016-04-04T10:29:16Z

[Term]
id: GO:1905104
name: obsolete response to ouabain
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ouabain stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23643758]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
is_obsolete: true
created_by: sl
creation_date: 2016-04-04T19:08:07Z

[Term]
id: GO:1905105
name: obsolete cellular response to ouabain
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ouabain stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23643758]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
is_obsolete: true
created_by: sl
creation_date: 2016-04-04T19:08:16Z

[Term]
id: GO:1905106
name: obsolete response to Dizocilpine
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Dizocilpine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20064280]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
is_obsolete: true
created_by: sl
creation_date: 2016-04-04T20:26:52Z

[Term]
id: GO:1905107
name: obsolete cellular response to Dizocilpine
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Dizocilpine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20064280]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
is_obsolete: true
created_by: sl
creation_date: 2016-04-04T20:27:01Z

[Term]
id: GO:1905108
name: guanosine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with guanosine." [GO_REF:0000067, GOC:TermGenie, PMID:26007660]
is_a: GO:0032550 ! purine ribonucleoside binding
created_by: al
creation_date: 2016-04-05T08:30:47Z

[Term]
id: GO:1905109
name: regulation of pulmonary blood vessel remodeling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pulmonary blood vessel remodeling." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164]
is_a: GO:0060312 ! regulation of blood vessel remodeling
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0101010 ! pulmonary blood vessel remodeling
relationship: regulates GO:0101010 ! pulmonary blood vessel remodeling
created_by: bc
creation_date: 2016-04-06T13:07:24Z

[Term]
id: GO:1905110
name: negative regulation of pulmonary blood vessel remodeling
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of pulmonary blood vessel remodeling." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164]
synonym: "down regulation of pulmonary blood vessel remodeling" EXACT [GOC:TermGenie]
synonym: "down-regulation of pulmonary blood vessel remodeling" EXACT [GOC:TermGenie]
synonym: "downregulation of pulmonary blood vessel remodeling" EXACT [GOC:TermGenie]
synonym: "inhibition of pulmonary blood vessel remodeling" NARROW [GOC:TermGenie]
is_a: GO:0060313 ! negative regulation of blood vessel remodeling
is_a: GO:1905109 ! regulation of pulmonary blood vessel remodeling
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0101010 ! pulmonary blood vessel remodeling
relationship: negatively_regulates GO:0101010 ! pulmonary blood vessel remodeling
created_by: bc
creation_date: 2016-04-06T13:07:33Z

[Term]
id: GO:1905111
name: positive regulation of pulmonary blood vessel remodeling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pulmonary blood vessel remodeling." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164]
synonym: "activation of pulmonary blood vessel remodeling" NARROW [GOC:TermGenie]
synonym: "up regulation of pulmonary blood vessel remodeling" EXACT [GOC:TermGenie]
synonym: "up-regulation of pulmonary blood vessel remodeling" EXACT [GOC:TermGenie]
synonym: "upregulation of pulmonary blood vessel remodeling" EXACT [GOC:TermGenie]
is_a: GO:1905109 ! regulation of pulmonary blood vessel remodeling
is_a: GO:2000504 ! positive regulation of blood vessel remodeling
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0101010 ! pulmonary blood vessel remodeling
relationship: positively_regulates GO:0101010 ! pulmonary blood vessel remodeling
created_by: bc
creation_date: 2016-04-06T13:07:42Z

[Term]
id: GO:1905112
name: regulation of centromere clustering at the nuclear envelope
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of centromere clustering at the nuclear envelope." [GO_REF:0000058, GOC:TermGenie, PMID:22375062]
synonym: "regulation of centromere clustering at the nuclear periphery" EXACT [GOC:TermGenie]
synonym: "regulation of centromere-SPB clustering" RELATED [GOC:TermGenie]
synonym: "regulation of kinetochore clustering at SPB" RELATED [GOC:TermGenie]
synonym: "regulation of kinetochore clustering at spindle pole body" RELATED [GOC:TermGenie]
synonym: "regulation of kinetochore clustering at the old mitotic spindle pole body" RELATED [GOC:TermGenie]
synonym: "regulation of kinetochore localization at spindle pole body" RELATED [GOC:TermGenie]
synonym: "regulation of rabl configuration" RELATED [GOC:TermGenie]
is_a: GO:0007346 ! regulation of mitotic cell cycle
is_a: GO:1903827 ! regulation of cellular protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072766 ! centromere clustering at the nuclear envelope
relationship: regulates GO:0072766 ! centromere clustering at the nuclear envelope
created_by: al
creation_date: 2016-04-06T16:25:41Z

[Term]
id: GO:1905113
name: positive regulation of centromere clustering at the nuclear envelope
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of centromere clustering at the nuclear envelope." [GO_REF:0000058, GOC:TermGenie, PMID:22375062]
synonym: "activation of centromere clustering at the nuclear envelope" NARROW [GOC:TermGenie]
synonym: "activation of centromere clustering at the nuclear periphery" NARROW [GOC:TermGenie]
synonym: "activation of centromere-SPB clustering" RELATED [GOC:TermGenie]
synonym: "activation of kinetochore clustering at SPB" RELATED [GOC:TermGenie]
synonym: "activation of kinetochore clustering at spindle pole body" RELATED [GOC:TermGenie]
synonym: "activation of kinetochore clustering at the old mitotic spindle pole body" RELATED [GOC:TermGenie]
synonym: "activation of kinetochore localization at spindle pole body" RELATED [GOC:TermGenie]
synonym: "activation of rabl configuration" RELATED [GOC:TermGenie]
synonym: "positive regulation of centromere clustering at the nuclear periphery" EXACT [GOC:TermGenie]
synonym: "positive regulation of centromere-SPB clustering" RELATED [GOC:TermGenie]
synonym: "positive regulation of kinetochore clustering at SPB" RELATED [GOC:TermGenie]
synonym: "positive regulation of kinetochore clustering at spindle pole body" RELATED [GOC:TermGenie]
synonym: "positive regulation of kinetochore clustering at the old mitotic spindle pole body" RELATED [GOC:TermGenie]
synonym: "positive regulation of kinetochore localization at spindle pole body" RELATED [GOC:TermGenie]
synonym: "positive regulation of rabl configuration" RELATED [GOC:TermGenie]
synonym: "up regulation of centromere clustering at the nuclear envelope" EXACT [GOC:TermGenie]
synonym: "up regulation of centromere clustering at the nuclear periphery" EXACT [GOC:TermGenie]
synonym: "up regulation of centromere-SPB clustering" RELATED [GOC:TermGenie]
synonym: "up regulation of kinetochore clustering at SPB" RELATED [GOC:TermGenie]
synonym: "up regulation of kinetochore clustering at spindle pole body" RELATED [GOC:TermGenie]
synonym: "up regulation of kinetochore clustering at the old mitotic spindle pole body" RELATED [GOC:TermGenie]
synonym: "up regulation of kinetochore localization at spindle pole body" RELATED [GOC:TermGenie]
synonym: "up regulation of rabl configuration" RELATED [GOC:TermGenie]
synonym: "up-regulation of centromere clustering at the nuclear envelope" EXACT [GOC:TermGenie]
synonym: "up-regulation of centromere clustering at the nuclear periphery" EXACT [GOC:TermGenie]
synonym: "up-regulation of centromere-SPB clustering" RELATED [GOC:TermGenie]
synonym: "up-regulation of kinetochore clustering at SPB" RELATED [GOC:TermGenie]
synonym: "up-regulation of kinetochore clustering at spindle pole body" RELATED [GOC:TermGenie]
synonym: "up-regulation of kinetochore clustering at the old mitotic spindle pole body" RELATED [GOC:TermGenie]
synonym: "up-regulation of kinetochore localization at spindle pole body" RELATED [GOC:TermGenie]
synonym: "up-regulation of rabl configuration" RELATED [GOC:TermGenie]
synonym: "upregulation of centromere clustering at the nuclear envelope" EXACT [GOC:TermGenie]
synonym: "upregulation of centromere clustering at the nuclear periphery" EXACT [GOC:TermGenie]
synonym: "upregulation of centromere-SPB clustering" RELATED [GOC:TermGenie]
synonym: "upregulation of kinetochore clustering at SPB" RELATED [GOC:TermGenie]
synonym: "upregulation of kinetochore clustering at spindle pole body" RELATED [GOC:TermGenie]
synonym: "upregulation of kinetochore clustering at the old mitotic spindle pole body" RELATED [GOC:TermGenie]
synonym: "upregulation of kinetochore localization at spindle pole body" RELATED [GOC:TermGenie]
synonym: "upregulation of rabl configuration" RELATED [GOC:TermGenie]
is_a: GO:0045931 ! positive regulation of mitotic cell cycle
is_a: GO:1903829 ! positive regulation of cellular protein localization
is_a: GO:1905112 ! regulation of centromere clustering at the nuclear envelope
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072766 ! centromere clustering at the nuclear envelope
relationship: positively_regulates GO:0072766 ! centromere clustering at the nuclear envelope
created_by: al
creation_date: 2016-04-06T16:25:49Z

[Term]
id: GO:1905114
name: cell surface receptor signaling pathway involved in cell-cell signaling
namespace: biological_process
def: "Any cell surface receptor signaling pathway that is involved in cell-cell signaling." [GO_REF:0000060, GOC:TermGenie, ISBN:0-7167-3051-0]
synonym: "cell surface receptor linked signal transduction involved in cell-cell signaling" EXACT [GOC:TermGenie]
synonym: "cell surface receptor linked signal transduction involved in cell-cell signalling" EXACT [GOC:TermGenie]
synonym: "cell surface receptor linked signaling pathway involved in cell-cell signaling" EXACT [GOC:TermGenie]
synonym: "cell surface receptor linked signaling pathway involved in cell-cell signalling" EXACT [GOC:TermGenie]
synonym: "cell surface receptor linked signalling pathway involved in cell-cell signaling" EXACT [GOC:TermGenie]
synonym: "cell surface receptor linked signalling pathway involved in cell-cell signalling" EXACT [GOC:TermGenie]
synonym: "cell surface receptor signaling pathway involved in cell-cell signalling" EXACT [GOC:TermGenie]
is_a: GO:0007166 ! cell surface receptor signaling pathway
intersection_of: GO:0007166 ! cell surface receptor signaling pathway
intersection_of: part_of GO:0007267 ! cell-cell signaling
relationship: part_of GO:0007267 ! cell-cell signaling
created_by: dos
creation_date: 2016-04-06T16:59:57Z

[Term]
id: GO:1905115
name: regulation of lateral attachment of mitotic spindle microtubules to kinetochore
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lateral attachment of mitotic spindle microtubules to kinetochore." [GO_REF:0000058, GOC:TermGenie, PMID:22375062]
is_a: GO:0090235 ! regulation of metaphase plate congression
is_a: GO:1902423 ! regulation of mitotic attachment of spindle microtubules to kinetochore
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0099607 ! lateral attachment of mitotic spindle microtubules to kinetochore
relationship: regulates GO:0099607 ! lateral attachment of mitotic spindle microtubules to kinetochore
created_by: al
creation_date: 2016-04-07T14:25:25Z

[Term]
id: GO:1905116
name: positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lateral attachment of mitotic spindle microtubules to kinetochore." [GO_REF:0000058, GOC:TermGenie, PMID:22375062]
synonym: "activation of lateral attachment of mitotic spindle microtubules to kinetochore" NARROW [GOC:TermGenie]
synonym: "up regulation of lateral attachment of mitotic spindle microtubules to kinetochore" EXACT [GOC:TermGenie]
synonym: "up-regulation of lateral attachment of mitotic spindle microtubules to kinetochore" EXACT [GOC:TermGenie]
synonym: "upregulation of lateral attachment of mitotic spindle microtubules to kinetochore" EXACT [GOC:TermGenie]
is_a: GO:1902425 ! positive regulation of attachment of mitotic spindle microtubules to kinetochore
is_a: GO:1905115 ! regulation of lateral attachment of mitotic spindle microtubules to kinetochore
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0099607 ! lateral attachment of mitotic spindle microtubules to kinetochore
relationship: positively_regulates GO:0099607 ! lateral attachment of mitotic spindle microtubules to kinetochore
created_by: al
creation_date: 2016-04-07T14:25:34Z

[Term]
id: GO:1905117
name: regulation of ribonucleoside-diphosphate reductase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ribonucleoside-diphosphate reductase activity." [GO_REF:0000059, GOC:bhm, GOC:TermGenie, PMID:24733891]
comment: An example of this is DRE2 in Saccharomyces cerevisiae (UniProt ID P36152) in PMID:24733891 (inferred from mutant phenotype).
synonym: "regulation of adenosylcobalamin-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "regulation of aerobic non-heme iron-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "regulation of anaerobic iron-sulfur-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "regulation of class I ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "regulation of class II ribonucleoside-diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "regulation of class II ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "regulation of class III ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "regulation of nucleoside diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "regulation of purine/pyrimidine nucleoside diphosphate reduction" RELATED [GOC:TermGenie]
synonym: "regulation of ribonucleoside 5'-diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "regulation of ribonucleotide diphosphate reductase activity" EXACT [GOC:TermGenie]
synonym: "regulation of ribonucleotide reductase activity" BROAD [GOC:TermGenie]
synonym: "regulation of RNR" RELATED [GOC:TermGenie]
is_a: GO:0051341 ! regulation of oxidoreductase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061731 ! ribonucleoside-diphosphate reductase activity
relationship: regulates GO:0061731 ! ribonucleoside-diphosphate reductase activity
created_by: bhm
creation_date: 2016-04-08T08:06:17Z

[Term]
id: GO:1905118
name: positive regulation of ribonucleoside-diphosphate reductase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ribonucleoside-diphosphate reductase activity." [GO_REF:0000059, GOC:bhm, GOC:TermGenie, PMID:24733891]
comment: An example of this is DRE2 in Saccharomyces cerevisiae (UniProt ID P36152) in PMID:24733891 (inferred from mutant phenotype).
synonym: "activation of adenosylcobalamin-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "activation of aerobic non-heme iron-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "activation of anaerobic iron-sulfur-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "activation of class I ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "activation of class II ribonucleoside-diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "activation of class II ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "activation of class III ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "activation of nucleoside diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "activation of purine/pyrimidine nucleoside diphosphate reduction" RELATED [GOC:TermGenie]
synonym: "activation of ribonucleoside 5'-diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "activation of ribonucleoside-diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "activation of ribonucleotide diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "activation of RNR" RELATED [GOC:TermGenie]
synonym: "positive regulation of adenosylcobalamin-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of aerobic non-heme iron-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of anaerobic iron-sulfur-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of class I ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of class II ribonucleoside-diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of class II ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of class III ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of nucleoside diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of purine/pyrimidine nucleoside diphosphate reduction" RELATED [GOC:TermGenie]
synonym: "positive regulation of ribonucleoside 5'-diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of ribonucleotide diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of RNR" RELATED [GOC:TermGenie]
synonym: "up regulation of adenosylcobalamin-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of aerobic non-heme iron-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of anaerobic iron-sulfur-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of class I ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of class II ribonucleoside-diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of class II ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of class III ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of nucleoside diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of purine/pyrimidine nucleoside diphosphate reduction" RELATED [GOC:TermGenie]
synonym: "up regulation of ribonucleoside 5'-diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of ribonucleoside-diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of ribonucleotide diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "up regulation of RNR" RELATED [GOC:TermGenie]
synonym: "up-regulation of adenosylcobalamin-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of aerobic non-heme iron-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of anaerobic iron-sulfur-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of class I ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of class II ribonucleoside-diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of class II ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of class III ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of nucleoside diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of purine/pyrimidine nucleoside diphosphate reduction" RELATED [GOC:TermGenie]
synonym: "up-regulation of ribonucleoside 5'-diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of ribonucleoside-diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of ribonucleotide diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of RNR" RELATED [GOC:TermGenie]
synonym: "upregulation of adenosylcobalamin-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "upregulation of aerobic non-heme iron-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "upregulation of anaerobic iron-sulfur-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "upregulation of class I ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "upregulation of class II ribonucleoside-diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "upregulation of class II ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "upregulation of class III ribonucleotide reductase activity" RELATED [GOC:TermGenie]
synonym: "upregulation of nucleoside diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "upregulation of purine/pyrimidine nucleoside diphosphate reduction" RELATED [GOC:TermGenie]
synonym: "upregulation of ribonucleoside 5'-diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "upregulation of ribonucleoside-diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "upregulation of ribonucleotide diphosphate reductase activity" RELATED [GOC:TermGenie]
synonym: "upregulation of RNR" RELATED [GOC:TermGenie]
is_a: GO:0051353 ! positive regulation of oxidoreductase activity
is_a: GO:1905117 ! regulation of ribonucleoside-diphosphate reductase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061731 ! ribonucleoside-diphosphate reductase activity
relationship: positively_regulates GO:0061731 ! ribonucleoside-diphosphate reductase activity
created_by: bhm
creation_date: 2016-04-08T08:06:35Z

[Term]
id: GO:1905119
name: response to haloperidol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a haloperidol stimulus." [GO_REF:0000071, GOC:dw, GOC:TermGenie, PMID:24751813]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0097305 ! response to alcohol
is_a: GO:1901654 ! response to ketone
created_by: dw
creation_date: 2016-04-08T12:36:39Z

[Term]
id: GO:1905120
name: cellular response to haloperidol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a haloperidol stimulus." [GO_REF:0000071, GOC:dw, GOC:TermGenie, PMID:24751813]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:0097306 ! cellular response to alcohol
is_a: GO:1901655 ! cellular response to ketone
is_a: GO:1905119 ! response to haloperidol
created_by: dw
creation_date: 2016-04-08T12:36:47Z

[Term]
id: GO:1905121
name: microtubule sliding involved in mitotic spindle elongation
namespace: biological_process
def: "Any microtubule sliding that is involved in mitotic spindle elongation." [GO_REF:0000060, GOC:TermGenie, GOC:vw, PMID:19686686]
synonym: "microtubule sliding involved in spindle elongation during mitosis" EXACT [GOC:TermGenie]
synonym: "microtubule translocation involved in mitotic spindle elongation" EXACT [GOC:TermGenie]
synonym: "microtubule translocation involved in spindle elongation during mitosis" EXACT [GOC:TermGenie]
is_a: GO:0051012 ! microtubule sliding
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0051012 ! microtubule sliding
intersection_of: part_of GO:0000022 ! mitotic spindle elongation
relationship: part_of GO:0000022 ! mitotic spindle elongation
created_by: pr
creation_date: 2016-04-08T15:06:14Z

[Term]
id: GO:1905122
name: polyamine import
namespace: biological_process
def: "The directed movement of polyamine macromolecule into a cell or organelle." [GO_REF:0000073, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23205587]
synonym: "polyamine uptake" RELATED [PMID:23205587]
is_a: GO:0015846 ! polyamine transport
created_by: bf
creation_date: 2016-04-11T13:26:09Z

[Term]
id: GO:1905123
name: regulation of glucosylceramidase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glucosylceramidase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24334770]
synonym: "regulation of acid beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "regulation of beta-D-glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "regulation of beta-glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "regulation of beta-glucosylceramidase activity" EXACT [GOC:TermGenie]
synonym: "regulation of ceramide glucosidase activity" EXACT [GOC:TermGenie]
synonym: "regulation of D-glucosyl-N-acylsphingosine glucohydrolase activity" EXACT [GOC:TermGenie]
synonym: "regulation of GCase activity" EXACT [PMID:24334770]
synonym: "regulation of GlcCer-beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "regulation of glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "regulation of glucosphingosine glucosylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "regulation of glucosylcerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "regulation of glucosylsphingosine beta-D-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "regulation of glucosylsphingosine beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "regulation of psychosine hydrolase activity" EXACT [GOC:TermGenie]
is_a: GO:0051336 ! regulation of hydrolase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004348 ! glucosylceramidase activity
relationship: regulates GO:0004348 ! glucosylceramidase activity
created_by: bf
creation_date: 2016-04-11T15:44:26Z

[Term]
id: GO:1905124
name: negative regulation of glucosylceramidase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glucosylceramidase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "down regulation of acid beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of beta-D-glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of beta-glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of beta-glucosylceramidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of ceramide glucosidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of D-glucosyl-N-acylsphingosine glucohydrolase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of GlcCer-beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of glucosphingosine glucosylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of glucosylceramidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of glucosylcerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of glucosylsphingosine beta-D-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of glucosylsphingosine beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "down regulation of psychosine hydrolase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of acid beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of beta-D-glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of beta-glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of beta-glucosylceramidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of ceramide glucosidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of D-glucosyl-N-acylsphingosine glucohydrolase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of GlcCer-beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of glucosphingosine glucosylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of glucosylceramidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of glucosylcerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of glucosylsphingosine beta-D-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of glucosylsphingosine beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of psychosine hydrolase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of acid beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of beta-D-glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of beta-glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of beta-glucosylceramidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of ceramide glucosidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of D-glucosyl-N-acylsphingosine glucohydrolase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of GlcCer-beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of glucosphingosine glucosylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of glucosylceramidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of glucosylcerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of glucosylsphingosine beta-D-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of glucosylsphingosine beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "downregulation of psychosine hydrolase activity" EXACT [GOC:TermGenie]
synonym: "inhibition of acid beta-glucosidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of beta-D-glucocerebrosidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of beta-glucocerebrosidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of beta-glucosylceramidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of ceramide glucosidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of D-glucosyl-N-acylsphingosine glucohydrolase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of GlcCer-beta-glucosidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of glucocerebrosidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of glucosphingosine glucosylhydrolase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of glucosylceramidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of glucosylcerebrosidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of glucosylsphingosine beta-D-glucosidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of glucosylsphingosine beta-glucosidase activity" NARROW [GOC:TermGenie]
synonym: "inhibition of psychosine hydrolase activity" NARROW [GOC:TermGenie]
synonym: "negative regulation of acid beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of beta-D-glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of beta-glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of beta-glucosylceramidase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of ceramide glucosidase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of D-glucosyl-N-acylsphingosine glucohydrolase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of GCase activity" EXACT [PMID:24334770]
synonym: "negative regulation of GlcCer-beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of glucosphingosine glucosylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of glucosylcerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of glucosylsphingosine beta-D-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of glucosylsphingosine beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of psychosine hydrolase activity" EXACT [GOC:TermGenie]
is_a: GO:0051346 ! negative regulation of hydrolase activity
is_a: GO:1905123 ! regulation of glucosylceramidase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004348 ! glucosylceramidase activity
relationship: negatively_regulates GO:0004348 ! glucosylceramidase activity
created_by: bf
creation_date: 2016-04-11T15:44:35Z

[Term]
id: GO:1905125
name: positive regulation of glucosylceramidase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glucosylceramidase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "activation of acid beta-glucosidase activity" NARROW [GOC:TermGenie]
synonym: "activation of beta-D-glucocerebrosidase activity" NARROW [GOC:TermGenie]
synonym: "activation of beta-glucocerebrosidase activity" NARROW [GOC:TermGenie]
synonym: "activation of beta-glucosylceramidase activity" NARROW [GOC:TermGenie]
synonym: "activation of ceramide glucosidase activity" NARROW [GOC:TermGenie]
synonym: "activation of D-glucosyl-N-acylsphingosine glucohydrolase activity" NARROW [GOC:TermGenie]
synonym: "activation of GlcCer-beta-glucosidase activity" NARROW [GOC:TermGenie]
synonym: "activation of glucocerebrosidase activity" NARROW [GOC:TermGenie]
synonym: "activation of glucosphingosine glucosylhydrolase activity" NARROW [GOC:TermGenie]
synonym: "activation of glucosylceramidase activity" NARROW [GOC:TermGenie]
synonym: "activation of glucosylcerebrosidase activity" NARROW [GOC:TermGenie]
synonym: "activation of glucosylsphingosine beta-D-glucosidase activity" NARROW [GOC:TermGenie]
synonym: "activation of glucosylsphingosine beta-glucosidase activity" NARROW [GOC:TermGenie]
synonym: "activation of psychosine hydrolase activity" NARROW [GOC:TermGenie]
synonym: "positive regulation of acid beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of beta-D-glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of beta-glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of beta-glucosylceramidase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of ceramide glucosidase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of D-glucosyl-N-acylsphingosine glucohydrolase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of GCase activity" EXACT [PMID:24334770]
synonym: "positive regulation of GlcCer-beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of glucosphingosine glucosylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of glucosylcerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of glucosylsphingosine beta-D-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of glucosylsphingosine beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of psychosine hydrolase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of acid beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of beta-D-glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of beta-glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of beta-glucosylceramidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of ceramide glucosidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of D-glucosyl-N-acylsphingosine glucohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of GlcCer-beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of glucosphingosine glucosylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of glucosylceramidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of glucosylcerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of glucosylsphingosine beta-D-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of glucosylsphingosine beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "up regulation of psychosine hydrolase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of acid beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of beta-D-glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of beta-glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of beta-glucosylceramidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of ceramide glucosidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of D-glucosyl-N-acylsphingosine glucohydrolase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of GlcCer-beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of glucosphingosine glucosylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of glucosylceramidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of glucosylcerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of glucosylsphingosine beta-D-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of glucosylsphingosine beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of psychosine hydrolase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of acid beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of beta-D-glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of beta-glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of beta-glucosylceramidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of ceramide glucosidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of D-glucosyl-N-acylsphingosine glucohydrolase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of GlcCer-beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of glucocerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of glucosphingosine glucosylhydrolase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of glucosylceramidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of glucosylcerebrosidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of glucosylsphingosine beta-D-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of glucosylsphingosine beta-glucosidase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of psychosine hydrolase activity" EXACT [GOC:TermGenie]
is_a: GO:0051345 ! positive regulation of hydrolase activity
is_a: GO:1905123 ! regulation of glucosylceramidase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004348 ! glucosylceramidase activity
relationship: positively_regulates GO:0004348 ! glucosylceramidase activity
created_by: bf
creation_date: 2016-04-11T15:44:43Z

[Term]
id: GO:1905126
name: regulation of axo-dendritic protein transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of axo-dendritic protein transport." [GO_REF:0000058, GOC:TermGenie, PMID:20694152]
synonym: "regulation of axonal protein transport" NARROW [GOC:TermGenie]
is_a: GO:0033157 ! regulation of intracellular protein transport
is_a: GO:0060632 ! regulation of microtubule-based movement
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0099640 ! axo-dendritic protein transport
relationship: regulates GO:0099640 ! axo-dendritic protein transport
created_by: sl
creation_date: 2016-04-11T20:38:31Z

[Term]
id: GO:1905127
name: negative regulation of axo-dendritic protein transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of axo-dendritic protein transport." [GO_REF:0000058, GOC:TermGenie, PMID:20694152]
synonym: "down regulation of axo-dendritic protein transport" EXACT [GOC:TermGenie]
synonym: "down regulation of axonal protein transport" NARROW [GOC:TermGenie]
synonym: "down-regulation of axo-dendritic protein transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of axonal protein transport" NARROW [GOC:TermGenie]
synonym: "downregulation of axo-dendritic protein transport" EXACT [GOC:TermGenie]
synonym: "downregulation of axonal protein transport" NARROW [GOC:TermGenie]
synonym: "inhibition of axo-dendritic protein transport" NARROW [GOC:TermGenie]
synonym: "inhibition of axonal protein transport" NARROW [GOC:TermGenie]
synonym: "negative regulation of axonal protein transport" NARROW [GOC:TermGenie]
is_a: GO:0051271 ! negative regulation of cellular component movement
is_a: GO:0090317 ! negative regulation of intracellular protein transport
is_a: GO:1905126 ! regulation of axo-dendritic protein transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0099640 ! axo-dendritic protein transport
relationship: negatively_regulates GO:0099640 ! axo-dendritic protein transport
created_by: sl
creation_date: 2016-04-11T20:38:40Z

[Term]
id: GO:1905128
name: positive regulation of axo-dendritic protein transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of axo-dendritic protein transport." [GO_REF:0000058, GOC:TermGenie, PMID:20694152]
synonym: "activation of axo-dendritic protein transport" NARROW [GOC:TermGenie]
synonym: "activation of axonal protein transport" NARROW [GOC:TermGenie]
synonym: "positive regulation of axonal protein transport" NARROW [GOC:TermGenie]
synonym: "up regulation of axo-dendritic protein transport" EXACT [GOC:TermGenie]
synonym: "up regulation of axonal protein transport" NARROW [GOC:TermGenie]
synonym: "up-regulation of axo-dendritic protein transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of axonal protein transport" NARROW [GOC:TermGenie]
synonym: "upregulation of axo-dendritic protein transport" EXACT [GOC:TermGenie]
synonym: "upregulation of axonal protein transport" NARROW [GOC:TermGenie]
is_a: GO:0051272 ! positive regulation of cellular component movement
is_a: GO:0090316 ! positive regulation of intracellular protein transport
is_a: GO:1905126 ! regulation of axo-dendritic protein transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0099640 ! axo-dendritic protein transport
relationship: positively_regulates GO:0099640 ! axo-dendritic protein transport
created_by: sl
creation_date: 2016-04-11T20:38:48Z

[Term]
id: GO:1905129
name: endocannabinoid signaling pathway involved in trans-synaptic signaling
namespace: biological_process
def: "Any endocannabinoid signaling pathway that is involved in trans-synaptic signaling by endocannabinoid." [GO_REF:0000060, GOC:TermGenie, PMID:23040807]
synonym: "endocannabinoid signalling pathway involved in trans-synaptic signaling by endocannabinoid" EXACT [GOC:TermGenie]
is_a: GO:0071926 ! endocannabinoid signaling pathway
intersection_of: GO:0071926 ! endocannabinoid signaling pathway
intersection_of: part_of GO:0099542 ! trans-synaptic signaling by endocannabinoid
relationship: part_of GO:0099542 ! trans-synaptic signaling by endocannabinoid
created_by: dos
creation_date: 2016-04-12T10:45:13Z

[Term]
id: GO:1905130
name: carcinine import across plasma membrane
namespace: biological_process
def: "The directed movement of carcinine from outside of a cell into the cytoplasmic compartment." [GO_REF:0000075, GOC:dph, GOC:TermGenie, PMID:26653853, PMID:26713872]
is_a: GO:0042886 ! amide transport
is_a: GO:0045117 ! azole transport
is_a: GO:0072337 ! modified amino acid transport
is_a: GO:0098739 ! import across plasma membrane
created_by: dph
creation_date: 2016-04-12T15:15:18Z

[Term]
id: GO:1905131
name: carcinine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of carcinine from one side of the membrane to the other." [GO_REF:0000070, GOC:dph, GOC:TermGenie, PMID:26653853, PMID:26713872]
is_a: GO:0042887 ! amide transmembrane transporter activity
is_a: GO:0072349 ! modified amino acid transmembrane transporter activity
is_a: GO:1901474 ! azole transmembrane transporter activity
created_by: dph
creation_date: 2016-04-12T15:18:25Z

[Term]
id: GO:1905132
name: regulation of meiotic chromosome separation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of meiotic chromosome separation." [GO_REF:0000058, GOC:TermGenie, GOC:vw, PMID:15620645]
synonym: "regulation of chromosome separation during meiosis" EXACT [GOC:TermGenie]
synonym: "regulation of meiotic chromosome resolution" EXACT [GOC:TermGenie]
is_a: GO:0040020 ! regulation of meiotic nuclear division
is_a: GO:0051983 ! regulation of chromosome segregation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051307 ! meiotic chromosome separation
relationship: regulates GO:0051307 ! meiotic chromosome separation
created_by: dph
creation_date: 2016-04-12T17:46:29Z

[Term]
id: GO:1905133
name: negative regulation of meiotic chromosome separation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of meiotic chromosome separation." [GO_REF:0000058, GOC:TermGenie, GOC:vw, PMID:15620645]
synonym: "down regulation of chromosome separation during meiosis" EXACT [GOC:TermGenie]
synonym: "down regulation of meiotic chromosome resolution" EXACT [GOC:TermGenie]
synonym: "down regulation of meiotic chromosome separation" EXACT [GOC:TermGenie]
synonym: "down-regulation of chromosome separation during meiosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of meiotic chromosome resolution" EXACT [GOC:TermGenie]
synonym: "down-regulation of meiotic chromosome separation" EXACT [GOC:TermGenie]
synonym: "downregulation of chromosome separation during meiosis" EXACT [GOC:TermGenie]
synonym: "downregulation of meiotic chromosome resolution" EXACT [GOC:TermGenie]
synonym: "downregulation of meiotic chromosome separation" EXACT [GOC:TermGenie]
synonym: "inhibition of chromosome separation during meiosis" NARROW [GOC:TermGenie]
synonym: "inhibition of meiotic chromosome resolution" NARROW [GOC:TermGenie]
synonym: "inhibition of meiotic chromosome separation" NARROW [GOC:TermGenie]
synonym: "negative regulation of chromosome separation during meiosis" EXACT [GOC:TermGenie]
synonym: "negative regulation of meiotic chromosome resolution" EXACT [GOC:TermGenie]
is_a: GO:0045835 ! negative regulation of meiotic nuclear division
is_a: GO:0051985 ! negative regulation of chromosome segregation
is_a: GO:1905132 ! regulation of meiotic chromosome separation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051307 ! meiotic chromosome separation
relationship: negatively_regulates GO:0051307 ! meiotic chromosome separation
created_by: dph
creation_date: 2016-04-12T17:46:37Z

[Term]
id: GO:1905134
name: positive regulation of meiotic chromosome separation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of meiotic chromosome separation." [GO_REF:0000058, GOC:TermGenie, GOC:vw, PMID:15620645]
synonym: "activation of chromosome separation during meiosis" NARROW [GOC:TermGenie]
synonym: "activation of meiotic chromosome resolution" NARROW [GOC:TermGenie]
synonym: "activation of meiotic chromosome separation" NARROW [GOC:TermGenie]
synonym: "positive regulation of chromosome separation during meiosis" EXACT [GOC:TermGenie]
synonym: "positive regulation of meiotic chromosome resolution" EXACT [GOC:TermGenie]
synonym: "up regulation of chromosome separation during meiosis" EXACT [GOC:TermGenie]
synonym: "up regulation of meiotic chromosome resolution" EXACT [GOC:TermGenie]
synonym: "up regulation of meiotic chromosome separation" EXACT [GOC:TermGenie]
synonym: "up-regulation of chromosome separation during meiosis" EXACT [GOC:TermGenie]
synonym: "up-regulation of meiotic chromosome resolution" EXACT [GOC:TermGenie]
synonym: "up-regulation of meiotic chromosome separation" EXACT [GOC:TermGenie]
synonym: "upregulation of chromosome separation during meiosis" EXACT [GOC:TermGenie]
synonym: "upregulation of meiotic chromosome resolution" EXACT [GOC:TermGenie]
synonym: "upregulation of meiotic chromosome separation" EXACT [GOC:TermGenie]
is_a: GO:0045836 ! positive regulation of meiotic nuclear division
is_a: GO:0051984 ! positive regulation of chromosome segregation
is_a: GO:1905132 ! regulation of meiotic chromosome separation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051307 ! meiotic chromosome separation
relationship: positively_regulates GO:0051307 ! meiotic chromosome separation
created_by: dph
creation_date: 2016-04-12T17:46:45Z

[Term]
id: GO:1905135
name: biotin import across plasma membrane
namespace: biological_process
def: "The directed movement of biotin from outside of a cell into the cytoplasmic compartment." [GO_REF:0000075, GOC:TermGenie, PMID:12557275]
is_a: GO:0035461 ! vitamin transmembrane transport
is_a: GO:0044756 ! biotin import into cell
is_a: GO:0098739 ! import across plasma membrane
is_a: GO:1905039 ! carboxylic acid transmembrane transport
created_by: vw
creation_date: 2016-04-12T19:43:56Z

[Term]
id: GO:1905136
name: dethiobiotin import across plasma membrane
namespace: biological_process
def: "The directed movement of dethiobiotin from outside of a cell into the cytoplasmic compartment." [GO_REF:0000075, GOC:TermGenie, PMID:12557275]
is_a: GO:0044757 ! dethiobiotin import into cell
is_a: GO:0098739 ! import across plasma membrane
is_a: GO:1905039 ! carboxylic acid transmembrane transport
created_by: vw
creation_date: 2016-04-12T19:46:30Z

[Term]
id: GO:1905137
name: regulation of viral DNA genome packaging via site-specific sequence recognition
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of viral DNA genome packaging via site-specific sequence recognition." [GO_REF:0000058, GOC:TermGenie, PMID:24711378]
is_a: GO:0033044 ! regulation of chromosome organization
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0051052 ! regulation of DNA metabolic process
is_a: GO:1903900 ! regulation of viral life cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0098035 ! viral DNA genome packaging via site-specific sequence recognition
relationship: regulates GO:0098035 ! viral DNA genome packaging via site-specific sequence recognition
created_by: pr
creation_date: 2016-04-13T11:37:13Z

[Term]
id: GO:1905138
name: positive regulation of viral DNA genome packaging via site-specific sequence recognition
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of viral DNA genome packaging via site-specific sequence recognition." [GO_REF:0000058, GOC:TermGenie, PMID:24711378]
synonym: "activation of viral DNA genome packaging via site-specific sequence recognition" NARROW [GOC:TermGenie]
synonym: "up regulation of viral DNA genome packaging via site-specific sequence recognition" EXACT [GOC:TermGenie]
synonym: "up-regulation of viral DNA genome packaging via site-specific sequence recognition" EXACT [GOC:TermGenie]
synonym: "upregulation of viral DNA genome packaging via site-specific sequence recognition" EXACT [GOC:TermGenie]
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:0051054 ! positive regulation of DNA metabolic process
is_a: GO:1903902 ! positive regulation of viral life cycle
is_a: GO:1905137 ! regulation of viral DNA genome packaging via site-specific sequence recognition
is_a: GO:2001252 ! positive regulation of chromosome organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0098035 ! viral DNA genome packaging via site-specific sequence recognition
relationship: positively_regulates GO:0098035 ! viral DNA genome packaging via site-specific sequence recognition
created_by: pr
creation_date: 2016-04-13T11:37:22Z

[Term]
id: GO:1905139
name: apical ectodermal ridge formation
namespace: biological_process
def: "The process that gives rise to the apical ectodermal ridge. This process pertains to the initial formation of a structure from unspecified parts." [GO_REF:0000081, GOC:TermGenie, PMID:18359901, PMID:9323126, PMID:9596583]
synonym: "AER formation" RELATED [GOC:TermGenie]
synonym: "apical epidermal ridge formation" EXACT [GOC:TermGenie]
synonym: "crista ectodermalis apicalis formation" RELATED [GOC:TermGenie]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0035107 ! appendage morphogenesis
created_by: dph
creation_date: 2016-04-13T11:46:40Z

[Term]
id: GO:1905140
name: regulation of apical ectodermal ridge formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of apical ectodermal ridge formation." [GO_REF:0000058, GOC:TermGenie, PMID:18359901]
synonym: "regulation of AER formation" RELATED [GOC:TermGenie]
synonym: "regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie]
synonym: "regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1905139 ! apical ectodermal ridge formation
relationship: regulates GO:1905139 ! apical ectodermal ridge formation
created_by: dph
creation_date: 2016-04-13T12:16:40Z

[Term]
id: GO:1905141
name: negative regulation of apical ectodermal ridge formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of apical ectodermal ridge formation." [GO_REF:0000058, GOC:TermGenie, PMID:18359901]
synonym: "down regulation of AER formation" RELATED [GOC:TermGenie]
synonym: "down regulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie]
synonym: "down regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie]
synonym: "down regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie]
synonym: "down-regulation of AER formation" RELATED [GOC:TermGenie]
synonym: "down-regulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie]
synonym: "downregulation of AER formation" RELATED [GOC:TermGenie]
synonym: "downregulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie]
synonym: "downregulation of apical epidermal ridge formation" EXACT [GOC:TermGenie]
synonym: "downregulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie]
synonym: "inhibition of AER formation" RELATED [GOC:TermGenie]
synonym: "inhibition of apical ectodermal ridge formation" NARROW [GOC:TermGenie]
synonym: "inhibition of apical epidermal ridge formation" NARROW [GOC:TermGenie]
synonym: "inhibition of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie]
synonym: "negative regulation of AER formation" RELATED [GOC:TermGenie]
synonym: "negative regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1905140 ! regulation of apical ectodermal ridge formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1905139 ! apical ectodermal ridge formation
relationship: negatively_regulates GO:1905139 ! apical ectodermal ridge formation
created_by: dph
creation_date: 2016-04-13T12:16:48Z

[Term]
id: GO:1905142
name: positive regulation of apical ectodermal ridge formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of apical ectodermal ridge formation." [GO_REF:0000058, GOC:TermGenie, PMID:18359901]
synonym: "activation of AER formation" RELATED [GOC:TermGenie]
synonym: "positive regulation of AER formation" RELATED [GOC:TermGenie]
synonym: "positive regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie]
synonym: "up regulation of AER formation" RELATED [GOC:TermGenie]
synonym: "up regulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie]
synonym: "up regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie]
synonym: "up regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie]
synonym: "up-regulation of AER formation" RELATED [GOC:TermGenie]
synonym: "up-regulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie]
synonym: "upregulation of AER formation" RELATED [GOC:TermGenie]
synonym: "upregulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie]
synonym: "upregulation of apical epidermal ridge formation" EXACT [GOC:TermGenie]
synonym: "upregulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1905140 ! regulation of apical ectodermal ridge formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1905139 ! apical ectodermal ridge formation
relationship: positively_regulates GO:1905139 ! apical ectodermal ridge formation
created_by: dph
creation_date: 2016-04-13T12:16:57Z

[Term]
id: GO:1905143
name: eukaryotic translation initiation factor 2 complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an eukaryotic translation initiation factor 2 complex." [GO_REF:0000079, GOC:TermGenie, PMID:23775072]
synonym: "eIF-2 assembly" EXACT [GOC:TermGenie]
synonym: "eIF-2 formation" EXACT [GOC:TermGenie]
synonym: "eIF2 assembly" EXACT [GOC:TermGenie]
synonym: "eIF2 formation" EXACT [GOC:TermGenie]
synonym: "eukaryotic translation initiation factor 2 complex formation" EXACT [GOC:TermGenie]
is_a: GO:0006461 ! protein complex assembly
created_by: dph
creation_date: 2016-04-14T00:25:51Z

[Term]
id: GO:1905144
name: response to acetylcholine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21238497]
is_a: GO:0010033 ! response to organic substance
is_a: GO:0060359 ! response to ammonium ion
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: dos
creation_date: 2016-04-14T08:54:49Z

[Term]
id: GO:1905145
name: cellular response to acetylcholine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21238497]
is_a: GO:0071242 ! cellular response to ammonium ion
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1905144 ! response to acetylcholine
created_by: dos
creation_date: 2016-04-14T08:54:58Z

[Term]
id: GO:1905146
name: lysosomal protein catabolic process
namespace: biological_process
def: "Any cellular protein catabolic process that takes place in a lysosome." [GO_REF:0000062, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24334770]
comment: Also consider annotating to the terms 'lysosomal microautophagy ; GO:0016237' or 'macroautophagy ; GO:0016236'.
synonym: "cellular protein breakdown in lysosome" EXACT [GOC:TermGenie]
synonym: "cellular protein catabolic process in lysosome" EXACT []
synonym: "cellular protein catabolism in lysosome" EXACT [GOC:TermGenie]
synonym: "cellular protein degradation in lysosome" EXACT [GOC:TermGenie]
synonym: "lysosomal protein catabolism" EXACT [GOC:bf]
synonym: "lysosomal protein degradation" EXACT [GOC:bf]
synonym: "lysosomal proteolysis" RELATED [PMID:24334770]
synonym: "proteolysis within lysosome" RELATED [GOC:bf]
is_a: GO:0007039 ! protein catabolic process in the vacuole
intersection_of: GO:0044257 ! cellular protein catabolic process
intersection_of: occurs_in GO:0005764 ! lysosome
relationship: occurs_in GO:0005764 ! lysosome
created_by: bf
creation_date: 2016-04-14T12:50:34Z

[Term]
id: GO:1905147
name: regulation of smooth muscle hypertrophy
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of smooth muscle hypertrophy." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164]
is_a: GO:0014743 ! regulation of muscle hypertrophy
is_a: GO:0043502 ! regulation of muscle adaptation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0014895 ! smooth muscle hypertrophy
relationship: regulates GO:0014895 ! smooth muscle hypertrophy
created_by: bc
creation_date: 2016-04-15T12:47:07Z

[Term]
id: GO:1905148
name: negative regulation of smooth muscle hypertrophy
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle hypertrophy." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164]
synonym: "down regulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie]
synonym: "down-regulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie]
synonym: "downregulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie]
synonym: "inhibition of smooth muscle hypertrophy" NARROW [GOC:TermGenie]
is_a: GO:0014741 ! negative regulation of muscle hypertrophy
is_a: GO:0014745 ! negative regulation of muscle adaptation
is_a: GO:1905147 ! regulation of smooth muscle hypertrophy
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0014895 ! smooth muscle hypertrophy
relationship: negatively_regulates GO:0014895 ! smooth muscle hypertrophy
created_by: bc
creation_date: 2016-04-15T12:47:16Z

[Term]
id: GO:1905149
name: positive regulation of smooth muscle hypertrophy
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of smooth muscle hypertrophy." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164]
synonym: "activation of smooth muscle hypertrophy" NARROW [GOC:TermGenie]
synonym: "up regulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie]
synonym: "up-regulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie]
synonym: "upregulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie]
is_a: GO:0014742 ! positive regulation of muscle hypertrophy
is_a: GO:0014744 ! positive regulation of muscle adaptation
is_a: GO:1905147 ! regulation of smooth muscle hypertrophy
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0014895 ! smooth muscle hypertrophy
relationship: positively_regulates GO:0014895 ! smooth muscle hypertrophy
created_by: bc
creation_date: 2016-04-15T12:47:24Z

[Term]
id: GO:1905150
name: regulation of voltage-gated sodium channel activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of voltage-gated sodium channel activity." [GO_REF:0000059, GOC:TermGenie, PMID:24198377]
synonym: "regulation of voltage gated sodium channel activity" EXACT [GOC:TermGenie]
synonym: "regulation of voltage-dependent sodium channel activity" EXACT [GOC:TermGenie]
synonym: "regulation of voltage-gated sodium ion channel activity" EXACT [GOC:TermGenie]
synonym: "regulation of voltage-sensitive sodium channel" EXACT [GOC:TermGenie]
is_a: GO:0042391 ! regulation of membrane potential
is_a: GO:2000649 ! regulation of sodium ion transmembrane transporter activity
is_a: GO:2001257 ! regulation of cation channel activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0005248 ! voltage-gated sodium channel activity
relationship: regulates GO:0005248 ! voltage-gated sodium channel activity
created_by: sl
creation_date: 2016-04-15T21:47:40Z

[Term]
id: GO:1905151
name: negative regulation of voltage-gated sodium channel activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated sodium channel activity." [GO_REF:0000059, GOC:TermGenie, PMID:24198377]
synonym: "down regulation of voltage gated sodium channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of voltage-dependent sodium channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of voltage-gated sodium channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of voltage-gated sodium ion channel activity" EXACT [GOC:TermGenie]
synonym: "down regulation of voltage-sensitive sodium channel" EXACT [GOC:TermGenie]
synonym: "down-regulation of voltage gated sodium channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of voltage-dependent sodium channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of voltage-gated sodium channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of voltage-gated sodium ion channel activity" EXACT [GOC:TermGenie]
synonym: "down-regulation of voltage-sensitive sodium channel" EXACT [GOC:TermGenie]
synonym: "downregulation of voltage gated sodium channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of voltage-dependent sodium channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of voltage-gated sodium channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of voltage-gated sodium ion channel activity" EXACT [GOC:TermGenie]
synonym: "downregulation of voltage-sensitive sodium channel" EXACT [GOC:TermGenie]
synonym: "inhibition of voltage gated sodium channel activity" NARROW [GOC:TermGenie]
synonym: "inhibition of voltage-dependent sodium channel activity" NARROW [GOC:TermGenie]
synonym: "inhibition of voltage-gated sodium channel activity" NARROW [GOC:TermGenie]
synonym: "inhibition of voltage-gated sodium ion channel activity" NARROW [GOC:TermGenie]
synonym: "inhibition of voltage-sensitive sodium channel" NARROW [GOC:TermGenie]
synonym: "negative regulation of voltage gated sodium channel activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of voltage-dependent sodium channel activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of voltage-gated sodium ion channel activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of voltage-sensitive sodium channel" EXACT [GOC:TermGenie]
is_a: GO:1905150 ! regulation of voltage-gated sodium channel activity
is_a: GO:2000650 ! negative regulation of sodium ion transmembrane transporter activity
is_a: GO:2001258 ! negative regulation of cation channel activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0005248 ! voltage-gated sodium channel activity
relationship: negatively_regulates GO:0005248 ! voltage-gated sodium channel activity
created_by: sl
creation_date: 2016-04-15T21:47:49Z

[Term]
id: GO:1905152
name: positive regulation of voltage-gated sodium channel activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of voltage-gated sodium channel activity." [GO_REF:0000059, GOC:TermGenie, PMID:24198377]
synonym: "activation of voltage gated sodium channel activity" NARROW [GOC:TermGenie]
synonym: "activation of voltage-dependent sodium channel activity" NARROW [GOC:TermGenie]
synonym: "activation of voltage-gated sodium channel activity" NARROW [GOC:TermGenie]
synonym: "activation of voltage-gated sodium ion channel activity" NARROW [GOC:TermGenie]
synonym: "activation of voltage-sensitive sodium channel" NARROW [GOC:TermGenie]
synonym: "positive regulation of voltage gated sodium channel activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of voltage-dependent sodium channel activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of voltage-gated sodium ion channel activity" EXACT [GOC:TermGenie]
synonym: "positive regulation of voltage-sensitive sodium channel" EXACT [GOC:TermGenie]
synonym: "up regulation of voltage gated sodium channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of voltage-dependent sodium channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of voltage-gated sodium channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of voltage-gated sodium ion channel activity" EXACT [GOC:TermGenie]
synonym: "up regulation of voltage-sensitive sodium channel" EXACT [GOC:TermGenie]
synonym: "up-regulation of voltage gated sodium channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of voltage-dependent sodium channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of voltage-gated sodium channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of voltage-gated sodium ion channel activity" EXACT [GOC:TermGenie]
synonym: "up-regulation of voltage-sensitive sodium channel" EXACT [GOC:TermGenie]
synonym: "upregulation of voltage gated sodium channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of voltage-dependent sodium channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of voltage-gated sodium channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of voltage-gated sodium ion channel activity" EXACT [GOC:TermGenie]
synonym: "upregulation of voltage-sensitive sodium channel" EXACT [GOC:TermGenie]
is_a: GO:1905150 ! regulation of voltage-gated sodium channel activity
is_a: GO:2000651 ! positive regulation of sodium ion transmembrane transporter activity
is_a: GO:2001259 ! positive regulation of cation channel activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0005248 ! voltage-gated sodium channel activity
relationship: positively_regulates GO:0005248 ! voltage-gated sodium channel activity
created_by: sl
creation_date: 2016-04-15T21:47:57Z

[Term]
id: GO:1905153
name: regulation of membrane invagination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of membrane invagination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:26589353]
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010324 ! membrane invagination
relationship: regulates GO:0010324 ! membrane invagination
created_by: bf
creation_date: 2016-04-18T15:43:54Z

[Term]
id: GO:1905154
name: negative regulation of membrane invagination
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of membrane invagination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:26589353]
synonym: "down regulation of membrane invagination" EXACT [GOC:TermGenie]
synonym: "down-regulation of membrane invagination" EXACT [GOC:TermGenie]
synonym: "downregulation of membrane invagination" EXACT [GOC:TermGenie]
synonym: "inhibition of membrane invagination" NARROW [GOC:TermGenie]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1905153 ! regulation of membrane invagination
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010324 ! membrane invagination
relationship: negatively_regulates GO:0010324 ! membrane invagination
created_by: bf
creation_date: 2016-04-18T15:44:04Z

[Term]
id: GO:1905155
name: positive regulation of membrane invagination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of membrane invagination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "activation of membrane invagination" NARROW [GOC:TermGenie]
synonym: "up regulation of membrane invagination" EXACT [GOC:TermGenie]
synonym: "up-regulation of membrane invagination" EXACT [GOC:TermGenie]
synonym: "upregulation of membrane invagination" EXACT [GOC:TermGenie]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1905153 ! regulation of membrane invagination
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010324 ! membrane invagination
relationship: positively_regulates GO:0010324 ! membrane invagination
created_by: bf
creation_date: 2016-04-18T15:44:12Z

[Term]
id: GO:1905156
name: negative regulation of photosynthesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of photosynthesis." [GO_REF:0000058, GOC:TermGenie, PMID:7592491]
synonym: "down regulation of photosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of photosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of photosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of photosynthesis" NARROW [GOC:TermGenie]
is_a: GO:0010109 ! regulation of photosynthesis
is_a: GO:0031324 ! negative regulation of cellular metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0015979 ! photosynthesis
relationship: negatively_regulates GO:0015979 ! photosynthesis
created_by: tb
creation_date: 2016-04-19T16:12:29Z

[Term]
id: GO:1905157
name: positive regulation of photosynthesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of photosynthesis." [GO_REF:0000058, GOC:TermGenie, PMID:7592491]
synonym: "activation of photosynthesis" NARROW [GOC:TermGenie]
synonym: "up regulation of photosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of photosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of photosynthesis" EXACT [GOC:TermGenie]
is_a: GO:0010109 ! regulation of photosynthesis
is_a: GO:0031325 ! positive regulation of cellular metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0015979 ! photosynthesis
relationship: positively_regulates GO:0015979 ! photosynthesis
created_by: tb
creation_date: 2016-04-19T16:12:39Z

[Term]
id: GO:1905158
name: obsolete regulation of Factor XII activation
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of Factor XII activation." [GO_REF:0000058, GOC:TermGenie, PMID:617517]
comment: This term was accidentally approved after TermGenie review.  It should not have been approved.
synonym: "regulation of Hageman factor activation" EXACT [GOC:TermGenie]
is_obsolete: true
created_by: sl
creation_date: 2016-04-19T23:03:25Z

[Term]
id: GO:1905159
name: obsolete negative regulation of Factor XII activation
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of Factor XII activation." [GO_REF:0000058, GOC:TermGenie, PMID:617517]
comment: This term was accidentally approved after TermGenie review.  It should not have been approved.
synonym: "down regulation of Factor XII activation" EXACT [GOC:TermGenie]
synonym: "down regulation of Hageman factor activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of Factor XII activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of Hageman factor activation" EXACT [GOC:TermGenie]
synonym: "downregulation of Factor XII activation" EXACT [GOC:TermGenie]
synonym: "downregulation of Hageman factor activation" EXACT [GOC:TermGenie]
synonym: "inhibition of Factor XII activation" NARROW [GOC:TermGenie]
synonym: "inhibition of Hageman factor activation" NARROW [GOC:TermGenie]
synonym: "negative regulation of Hageman factor activation" EXACT [GOC:TermGenie]
is_obsolete: true
created_by: sl
creation_date: 2016-04-19T23:03:34Z

[Term]
id: GO:1905160
name: obsolete positive regulation of Factor XII activation
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of Factor XII activation." [GO_REF:0000058, GOC:TermGenie, PMID:617517]
comment: This term was accidentally approved after TermGenie review.  It should not have been approved.
synonym: "activation of Factor XII activation" NARROW [GOC:TermGenie]
synonym: "activation of Hageman factor activation" NARROW [GOC:TermGenie]
synonym: "positive regulation of Hageman factor activation" EXACT [GOC:TermGenie]
synonym: "up regulation of Factor XII activation" EXACT [GOC:TermGenie]
synonym: "up regulation of Hageman factor activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of Factor XII activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of Hageman factor activation" EXACT [GOC:TermGenie]
synonym: "upregulation of Factor XII activation" EXACT [GOC:TermGenie]
synonym: "upregulation of Hageman factor activation" EXACT [GOC:TermGenie]
is_obsolete: true
created_by: sl
creation_date: 2016-04-19T23:03:43Z

[Term]
id: GO:1905161
name: protein localization to phagocytic vesicle
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a phagocytic vesicle." [GO_REF:0000087, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23303671]
synonym: "protein localisation in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "protein localisation to phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "protein localisation to phagosome" EXACT [PMID:23303671]
synonym: "protein localization in phagocytic vesicle" EXACT [GOC:TermGenie]
synonym: "protein recruitment to phagosome" EXACT [PMID:23303671]
is_a: GO:0033365 ! protein localization to organelle
created_by: bf
creation_date: 2016-04-25T15:05:13Z

[Term]
id: GO:1905162
name: regulation of phagosome maturation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phagosome maturation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:16908865, PMID:23303671]
is_a: GO:0033043 ! regulation of organelle organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0090382 ! phagosome maturation
relationship: regulates GO:0090382 ! phagosome maturation
created_by: bf
creation_date: 2016-04-25T16:28:03Z

[Term]
id: GO:1905163
name: negative regulation of phagosome maturation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of phagosome maturation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "down regulation of phagosome maturation" EXACT [GOC:TermGenie]
synonym: "down-regulation of phagosome maturation" EXACT [GOC:TermGenie]
synonym: "downregulation of phagosome maturation" EXACT [GOC:TermGenie]
synonym: "inhibition of phagosome maturation" NARROW [GOC:TermGenie]
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:1905162 ! regulation of phagosome maturation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0090382 ! phagosome maturation
relationship: negatively_regulates GO:0090382 ! phagosome maturation
created_by: bf
creation_date: 2016-04-25T16:28:11Z

[Term]
id: GO:1905164
name: positive regulation of phagosome maturation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phagosome maturation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "activation of phagosome maturation" NARROW [GOC:TermGenie]
synonym: "up regulation of phagosome maturation" EXACT [GOC:TermGenie]
synonym: "up-regulation of phagosome maturation" EXACT [GOC:TermGenie]
synonym: "upregulation of phagosome maturation" EXACT [GOC:TermGenie]
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:1905162 ! regulation of phagosome maturation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0090382 ! phagosome maturation
relationship: positively_regulates GO:0090382 ! phagosome maturation
created_by: bf
creation_date: 2016-04-25T16:28:19Z

[Term]
id: GO:1905165
name: regulation of lysosomal protein catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lysosomal protein catabolic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23499937]
synonym: "regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie]
synonym: "regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie]
synonym: "regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie]
synonym: "regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie]
synonym: "regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of lysosomal protein degradation" EXACT [GOC:TermGenie]
synonym: "regulation of lysosomal proteolysis" RELATED [GOC:TermGenie]
synonym: "regulation of proteolysis within lysosome" RELATED [GOC:TermGenie]
is_a: GO:1904350 ! regulation of protein catabolic process in the vacuole
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1905146 ! lysosomal protein catabolic process
relationship: regulates GO:1905146 ! lysosomal protein catabolic process
created_by: bf
creation_date: 2016-04-26T12:10:01Z

[Term]
id: GO:1905166
name: negative regulation of lysosomal protein catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lysosomal protein catabolic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "down regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie]
synonym: "down regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie]
synonym: "down regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie]
synonym: "down regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie]
synonym: "down regulation of lysosomal protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of lysosomal protein degradation" EXACT [GOC:TermGenie]
synonym: "down regulation of lysosomal proteolysis" RELATED [GOC:TermGenie]
synonym: "down regulation of proteolysis within lysosome" RELATED [GOC:TermGenie]
synonym: "down-regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie]
synonym: "down-regulation of lysosomal protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of lysosomal protein degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of lysosomal proteolysis" RELATED [GOC:TermGenie]
synonym: "down-regulation of proteolysis within lysosome" RELATED [GOC:TermGenie]
synonym: "downregulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie]
synonym: "downregulation of lysosomal protein catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of lysosomal protein catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of lysosomal protein degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of lysosomal proteolysis" RELATED [GOC:TermGenie]
synonym: "downregulation of proteolysis within lysosome" RELATED [GOC:TermGenie]
synonym: "inhibition of cellular protein breakdown in lysosome" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular protein catabolic process in lysosome" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular protein catabolism in lysosome" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular protein degradation in lysosome" NARROW [GOC:TermGenie]
synonym: "inhibition of lysosomal protein catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of lysosomal protein catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of lysosomal protein degradation" NARROW [GOC:TermGenie]
synonym: "inhibition of lysosomal proteolysis" RELATED [GOC:TermGenie]
synonym: "inhibition of proteolysis within lysosome" RELATED [GOC:TermGenie]
synonym: "negative regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie]
synonym: "negative regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie]
synonym: "negative regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie]
synonym: "negative regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie]
synonym: "negative regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of lysosomal protein degradation" EXACT [GOC:TermGenie]
synonym: "negative regulation of lysosomal proteolysis" RELATED [GOC:TermGenie]
synonym: "negative regulation of proteolysis within lysosome" RELATED [GOC:TermGenie]
is_a: GO:1904351 ! negative regulation of protein catabolic process in the vacuole
is_a: GO:1905165 ! regulation of lysosomal protein catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1905146 ! lysosomal protein catabolic process
relationship: negatively_regulates GO:1905146 ! lysosomal protein catabolic process
created_by: bf
creation_date: 2016-04-26T12:10:10Z

[Term]
id: GO:1905167
name: positive regulation of lysosomal protein catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lysosomal protein catabolic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "activation of cellular protein breakdown in lysosome" NARROW [GOC:TermGenie]
synonym: "activation of cellular protein catabolic process in lysosome" NARROW [GOC:TermGenie]
synonym: "activation of cellular protein catabolism in lysosome" NARROW [GOC:TermGenie]
synonym: "activation of cellular protein degradation in lysosome" NARROW [GOC:TermGenie]
synonym: "activation of lysosomal protein catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of lysosomal protein catabolism" NARROW [GOC:TermGenie]
synonym: "activation of lysosomal protein degradation" NARROW [GOC:TermGenie]
synonym: "activation of lysosomal proteolysis" RELATED [GOC:TermGenie]
synonym: "activation of proteolysis within lysosome" RELATED [GOC:TermGenie]
synonym: "positive regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie]
synonym: "positive regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie]
synonym: "positive regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie]
synonym: "positive regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie]
synonym: "positive regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of lysosomal protein degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of lysosomal proteolysis" RELATED [GOC:TermGenie]
synonym: "positive regulation of proteolysis within lysosome" RELATED [GOC:TermGenie]
synonym: "up regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie]
synonym: "up regulation of lysosomal protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of lysosomal protein degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of lysosomal proteolysis" RELATED [GOC:TermGenie]
synonym: "up regulation of proteolysis within lysosome" RELATED [GOC:TermGenie]
synonym: "up-regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie]
synonym: "up-regulation of lysosomal protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of lysosomal protein degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of lysosomal proteolysis" RELATED [GOC:TermGenie]
synonym: "up-regulation of proteolysis within lysosome" RELATED [GOC:TermGenie]
synonym: "upregulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie]
synonym: "upregulation of lysosomal protein catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of lysosomal protein catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of lysosomal protein degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of lysosomal proteolysis" RELATED [GOC:TermGenie]
synonym: "upregulation of proteolysis within lysosome" RELATED [GOC:TermGenie]
is_a: GO:1904352 ! positive regulation of protein catabolic process in the vacuole
is_a: GO:1905165 ! regulation of lysosomal protein catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1905146 ! lysosomal protein catabolic process
relationship: positively_regulates GO:1905146 ! lysosomal protein catabolic process
created_by: bf
creation_date: 2016-04-26T12:10:19Z

[Term]
id: GO:1905168
name: positive regulation of double-strand break repair via homologous recombination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of double-strand break repair via homologous recombination." [GO_REF:0000058, GOC:TermGenie, PMID:12023299]
synonym: "activation of double-strand break repair via homologous recombination" NARROW [GOC:TermGenie]
synonym: "activation of HDR" NARROW [GOC:TermGenie]
synonym: "activation of homologous recombinational repair" NARROW [GOC:TermGenie]
synonym: "activation of homology-directed repair" NARROW [GOC:TermGenie]
synonym: "activation of HRR" NARROW [GOC:TermGenie]
synonym: "activation of Rad51-dependent recombinational repair" NARROW [GOC:TermGenie]
synonym: "activation of Rhp51-dependent recombinational repair" NARROW [GOC:TermGenie]
synonym: "positive regulation of HDR" EXACT [GOC:TermGenie]
synonym: "positive regulation of homologous recombinational repair" EXACT [GOC:TermGenie]
synonym: "positive regulation of homology-directed repair" EXACT [GOC:TermGenie]
synonym: "positive regulation of HRR" EXACT [GOC:TermGenie]
synonym: "positive regulation of Rad51-dependent recombinational repair" EXACT [GOC:TermGenie]
synonym: "positive regulation of Rhp51-dependent recombinational repair" EXACT [GOC:TermGenie]
synonym: "up regulation of double-strand break repair via homologous recombination" EXACT [GOC:TermGenie]
synonym: "up regulation of HDR" EXACT [GOC:TermGenie]
synonym: "up regulation of homologous recombinational repair" EXACT [GOC:TermGenie]
synonym: "up regulation of homology-directed repair" EXACT [GOC:TermGenie]
synonym: "up regulation of HRR" EXACT [GOC:TermGenie]
synonym: "up regulation of Rad51-dependent recombinational repair" EXACT [GOC:TermGenie]
synonym: "up regulation of Rhp51-dependent recombinational repair" EXACT [GOC:TermGenie]
synonym: "up-regulation of double-strand break repair via homologous recombination" EXACT [GOC:TermGenie]
synonym: "up-regulation of HDR" EXACT [GOC:TermGenie]
synonym: "up-regulation of homologous recombinational repair" EXACT [GOC:TermGenie]
synonym: "up-regulation of homology-directed repair" EXACT [GOC:TermGenie]
synonym: "up-regulation of HRR" EXACT [GOC:TermGenie]
synonym: "up-regulation of Rad51-dependent recombinational repair" EXACT [GOC:TermGenie]
synonym: "up-regulation of Rhp51-dependent recombinational repair" EXACT [GOC:TermGenie]
synonym: "upregulation of double-strand break repair via homologous recombination" EXACT [GOC:TermGenie]
synonym: "upregulation of HDR" EXACT [GOC:TermGenie]
synonym: "upregulation of homologous recombinational repair" EXACT [GOC:TermGenie]
synonym: "upregulation of homology-directed repair" EXACT [GOC:TermGenie]
synonym: "upregulation of HRR" EXACT [GOC:TermGenie]
synonym: "upregulation of Rad51-dependent recombinational repair" EXACT [GOC:TermGenie]
synonym: "upregulation of Rhp51-dependent recombinational repair" EXACT [GOC:TermGenie]
is_a: GO:0010569 ! regulation of double-strand break repair via homologous recombination
is_a: GO:0045911 ! positive regulation of DNA recombination
is_a: GO:2000781 ! positive regulation of double-strand break repair
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000724 ! double-strand break repair via homologous recombination
relationship: positively_regulates GO:0000724 ! double-strand break repair via homologous recombination
created_by: mah
creation_date: 2016-04-27T12:48:47Z

[Term]
id: GO:1990000
name: amyloid fibril formation
namespace: biological_process
def: "The generation of amyloid fibrils, insoluble fibrous protein aggregates exhibiting beta sheet structure, from proteins. An example of this is seen when human RIP1 and RIP3 kinases form a heterodimeric functional amyloid signaling complex (PMID:22817896)." [GOC:cvs, GOC:jj, GOC:ppm, GOC:sj, PMID:16533927, PMID:21148556, PMID:22817896]
synonym: "amyloid fibril assembly" RELATED []
synonym: "amyloid structure assembly" RELATED []
synonym: "amyloid structure formation" RELATED []
is_a: GO:0019538 ! protein metabolic process
is_a: GO:0044710 ! single-organism metabolic process
is_a: GO:0097435 ! fibril organization
created_by: pr
creation_date: 2012-11-27T16:01:02Z

[Term]
id: GO:1990001
name: inhibition of cysteine-type endopeptidase activity involved in apoptotic process
namespace: biological_process
def: "Any process that prevents the activation of an inactive cysteine-type endopeptidase involved in an apoptotic process." [GOC:mtg_apoptosis, PMID:11943137]
is_a: GO:0043154 ! negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
is_a: GO:0097340 ! inhibition of cysteine-type endopeptidase activity
created_by: pr
creation_date: 2012-12-05T15:42:50Z

[Term]
id: GO:1990002
name: methylglyoxal reductase (NADPH-dependent, acetol producing)
namespace: molecular_function
def: "Catalysis of the reaction: H+ + methylglyoxal + NADPH <=> hydroxyacetone + NADP+." [EC:1.1.1.-, MetaCyc:RXN0-4281, PMID:16077126, RHEA:27989]
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
created_by: jl
creation_date: 2012-12-05T15:55:06Z

[Term]
id: GO:1990003
name: IDP phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: IDP + H2O = IMP + phosphate." [PMID:20385596]
xref: EC:3.1.3.-
is_a: GO:0098519 ! nucleotide phosphatase activity, acting on free nucleotides
created_by: jl
creation_date: 2012-12-05T16:46:52Z

[Term]
id: GO:1990004
name: XDP phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: XDP + H2O = XMP + phosphate." [PMID:20385596]
is_a: GO:0098519 ! nucleotide phosphatase activity, acting on free nucleotides
created_by: jl
creation_date: 2012-12-11T14:01:34Z

[Term]
id: GO:1990005
name: granular vesicle
namespace: cellular_component
def: "A cytoplasmic membrane-bounded vesicle of varying size, but usually larger than 45 nm, with an electron dense granular core, found in noradrenergic and peptidergic cells." [NIF_Subcellular:sao478230652]
xref: NIF_Subcellular:sao478230652
is_a: GO:0016023 ! cytoplasmic, membrane-bounded vesicle
created_by: pr
creation_date: 2012-12-11T14:51:48Z

[Term]
id: GO:1990006
name: amorphous vesicle
namespace: cellular_component
def: "A cytoplasmic membrane-bounded vesicle first described in dendrites, categorized by smooth membranes, electron-lucent interiors and irregular shapes. Sometimes occurs in clumps. Amorphous vesicles have been found to contain material taken up from the extracellular space, therefore suggesting that they may be part of the endosomal pathway." [NIF_Subcellular:sao1531915298, PMID:11896161]
xref: NIF_Subcellular:sao1531915298
is_a: GO:0016023 ! cytoplasmic, membrane-bounded vesicle
created_by: pr
creation_date: 2012-12-11T14:55:36Z

[Term]
id: GO:1990007
name: membrane stack
namespace: cellular_component
def: "A configuration of endoplasmic reticulum (ER) found in Purkinje cells in the cerebellum and in axons in the lateral vestibular nucleus, consisting of parallel and interconnecting tubules whose outer surfaces are covered by particles or ringlike structures." [ISBN:01950657191, NIF_Subcellular:sao2114874506]
xref: NIF_Subcellular:sao2114874506
is_a: GO:0005783 ! endoplasmic reticulum
created_by: pr
creation_date: 2012-12-11T14:58:16Z

[Term]
id: GO:1990008
name: neurosecretory vesicle
namespace: cellular_component
def: "A large cytoplasmic membrane-bounded vesicle with an electron dense granular core, up to 150-200 nm in diameter, found in neurosecretory cells in the hypothalamus." [ISBN:01950657191, NIF_Subcellular:sao2031592629]
xref: NIF_Subcellular:sao2031592629
is_a: GO:1990005 ! granular vesicle
created_by: pr
creation_date: 2012-12-12T09:56:14Z

[Term]
id: GO:1990009
name: retinal cell apoptotic process
namespace: biological_process
alt_id: GO:0046674
def: "Any apoptotic process in a retinal cell." [GOC:mtg_apoptosis, PMID:15558487, PMID:24664675]
synonym: "induction of retinal programmed cell death" RELATED []
is_a: GO:0006915 ! apoptotic process
created_by: pr
creation_date: 2012-12-12T10:15:08Z

[Term]
id: GO:1990010
name: compound eye retinal cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a compound eye retinal cell." [GOC:mtg_apoptosis, PMID:12021768]
is_a: GO:1990009 ! retinal cell apoptotic process
created_by: pr
creation_date: 2012-12-12T10:21:07Z

[Term]
id: GO:1990011
name: laminated body
namespace: cellular_component
def: "Inclusion body characterized by regularly spaced sheets of tubules arranged in a whorl pattern resembling a fingerprint. Laminated bodies have been observed in neurons of the lateral geniculate nucleus." [ISBN:01950657191, NIF_Subcellular:sao506721981]
synonym: "laminated inclusion body" EXACT []
xref: NIF_Subcellular:sao506721981
is_a: GO:0016234 ! inclusion body
created_by: pr
creation_date: 2012-12-12T14:12:21Z

[Term]
id: GO:1990012
name: complex laminated body
namespace: cellular_component
def: "A cytoplasmic inclusion body found in some lateral geniculate neurons and composed of sheets of tubules (25 nm in diameter) separated by dense material (about 75 nm wide), which together with the tubules whorl give a structure resembling a fingerprint." [NIF_Subcellular:nlx_151681]
synonym: "CLB" RELATED []
xref: NIF_Subcellular:nlx_151681
is_a: GO:1990011 ! laminated body
created_by: pr
creation_date: 2012-12-12T14:18:15Z

[Term]
id: GO:1990013
name: presynaptic grid
namespace: cellular_component
def: "A hexagonal array of electron dense particles attached to the cytoplasmic face of the presynaptic membrane." [ISBN:0716723808, NIF_Subcellular:sao1730664005]
synonym: "pre-synaptic grid" EXACT []
xref: NIF_Subcellular:sao1730664005
is_a: GO:0044456 ! synapse part
is_a: GO:0097458 ! neuron part
relationship: part_of GO:0048786 ! presynaptic active zone
created_by: pr
creation_date: 2012-12-13T09:00:35Z

[Term]
id: GO:1990014
name: orthogonal array
namespace: cellular_component
def: "Square array of closely spaced intramembrane particles, 4-6 nm in size, that form supramolecular aggregates found in the plasma membrane of astrocytes, skeletal muscle and epithelial cells. They have been shown to contain aquaporins (water channels)." [NIF_Subcellular:sao1747012216, PMID:22718347]
synonym: "OAP" RELATED []
synonym: "orthogonal array of particles" EXACT []
synonym: "square array" RELATED []
xref: NIF_Subcellular:sao1747012216
is_a: GO:0044459 ! plasma membrane part
created_by: pr
creation_date: 2012-12-13T20:14:15Z

[Term]
id: GO:1990015
name: ensheathing process
namespace: cellular_component
def: "A cell projection (often from glial cells such as Schwann cells) that surrounds an unmyelinated axon or cell soma." [NIF_Subcellular:sao1376748732]
synonym: "ensheathing process of Schwann cell" NARROW []
xref: NIF_Subcellular:sao1376748732
is_a: GO:0044464 ! cell part
created_by: pr
creation_date: 2012-12-19T09:42:15Z

[Term]
id: GO:1990016
name: neck portion of tanycyte
namespace: cellular_component
def: "Elongated portion of a tanycyte that sticks into the periventricular layer of neuropil where it appears to contact a blood vessel; characterized by numerous cytoplasmic extensions. A tanycyte is a specialized elongated ventricular ependymal cell that has processes that extend to the outer, or pial, surface of the CNS." [ISBN:01950657191, NIF_Subcellular:sao901230115]
synonym: "neck portion" BROAD []
xref: NIF_Subcellular:sao901230115
is_a: GO:0044464 ! cell part
created_by: pr
creation_date: 2012-12-19T15:17:17Z

[Term]
id: GO:1990017
name: somatic portion of tanycyte
namespace: cellular_component
def: "Portion of a tanycyte that lies within the ependyma and contains the nucleus. A tanycyte is a specialized elongated ventricular ependymal cell that has processes that extend to the outer, or pial, surface of the CNS." [ISBN:01950657191, NIF_Subcellular:sao401910342]
synonym: "somatic portion" BROAD []
xref: NIF_Subcellular:sao401910342
is_a: GO:0044297 ! cell body
created_by: pr
creation_date: 2012-12-19T15:19:25Z

[Term]
id: GO:1990018
name: tail portion of tanycyte
namespace: cellular_component
def: "Elongated process of a tanycyte, devoid of cytoplasmic extensions, that courses through the hypothalamic nuclei to form small endfoot processes that terminate either on blood vessels or at the pial surface of the brain. A tanycyte is a specialized elongated ventricular ependymal cell." [ISBN:01950657191, NIF_Subcellular:sao1749953771]
synonym: "tail portion" BROAD []
xref: NIF_Subcellular:sao1749953771
is_a: GO:0044464 ! cell part
created_by: pr
creation_date: 2012-12-19T15:21:20Z

[Term]
id: GO:1990019
name: protein storage vacuole organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a protein storage vacuole, a storage vacuole that contains a lytic vacuole." [GOC:tb, PMID:21670741]
is_a: GO:0007033 ! vacuole organization
created_by: tb
creation_date: 2012-12-20T21:00:09Z

[Term]
id: GO:1990020
name: recurrent axon collateral
namespace: cellular_component
def: "Axon collateral that ramifies in the area of the soma of the cell of origin." [NIF_Subcellular:sao1642494436]
synonym: "recurrent collateral" BROAD []
xref: NIF_Subcellular:sao1642494436
is_a: GO:0044303 ! axon collateral
created_by: pr
creation_date: 2013-01-10T16:04:31Z

[Term]
id: GO:1990021
name: Schaffer axon collateral
namespace: cellular_component
def: "Part of axon of a CA3 pyramidal neuron that projects to hippocampal area CA1." [NIF_Subcellular:nlx_subcell_20090511]
synonym: "Schaffer collateral" BROAD [NIF_Subcellular:sao1950673097]
xref: NIF_Subcellular:nlx_subcell_20090511
is_a: GO:0044303 ! axon collateral
created_by: pr
creation_date: 2013-01-10T16:06:17Z

[Term]
id: GO:1990022
name: RNA polymerase III complex localization to nucleus
namespace: biological_process
def: "The directed movement of an RNA polymerase III complex from the cytoplasm to the nucleus." [GOC:mcc, PMID:23267056]
synonym: "DNA-directed RNA polymerase III complex import into nucleus" EXACT []
synonym: "DNA-directed RNA polymerase III complex localization to nucleus" EXACT []
synonym: "RNA polymerase III complex import into nucleus" EXACT []
synonym: "RNA polymerase III complex localisation to nucleus" EXACT []
is_a: GO:0034504 ! protein localization to nucleus
is_a: GO:0034629 ! cellular protein complex localization
created_by: pr
creation_date: 2013-01-15T12:46:26Z

[Term]
id: GO:1990023
name: mitotic spindle midzone
namespace: cellular_component
def: "The area in the center of the anaphase spindle consisting of microtubules, microtubule bundling factors and kinesin motors where the spindle microtubules from opposite poles overlap in an antiparallel manner." [GOC:mtg_cell_cycle, GOC:vw]
is_a: GO:0051233 ! spindle midzone
relationship: part_of GO:0072686 ! mitotic spindle
created_by: vw
creation_date: 2013-02-05T15:41:48Z

[Term]
id: GO:1990024
name: C bouton
namespace: cellular_component
def: "Synaptic bouton found in spinal cord on the soma and proximal dendrites of motor neurons." [NIF_Subcellular:nlx_subcell_100208]
xref: NIF_Subcellular:nlx_subcell_100208
is_a: GO:0043195 ! terminal bouton
created_by: pr
creation_date: 2013-02-06T10:27:41Z

[Term]
id: GO:1990025
name: F bouton
namespace: cellular_component
def: "Synaptic bouton found in the ventral horn of the spinal cord. F boutons range in diameter from 0.5 to 7 um and contain flattened or pleomorphic synaptic vesicles." [NIF_Subcellular:nlx_subcell_100206]
xref: NIF_Subcellular:nlx_subcell_100206
is_a: GO:0043195 ! terminal bouton
created_by: pr
creation_date: 2013-02-06T10:29:42Z

[Term]
id: GO:1990026
name: hippocampal mossy fiber expansion
namespace: cellular_component
def: "Synaptic expansion of hippocampal mossy fiber axon that makes contact with the thorny excrescences of hippocampal CA3 pyramidal cell dendrites." [NIF_Subcellular:nlx_subcell_1005002]
synonym: "dentate gyrus granule cell axonal bouton" RELATED []
synonym: "dentate gyrus mossy fiber expansion" RELATED []
synonym: "mossy fiber expansion" BROAD []
xref: NIF_Subcellular:nlx_subcell_1005002
is_a: GO:0043195 ! terminal bouton
created_by: pr
creation_date: 2013-02-06T10:31:59Z

[Term]
id: GO:1990027
name: S bouton
namespace: cellular_component
def: "Synaptic bouton found in the ventral horn of the spinal cord. S boutons range in diameter from 0.5 to 8 um and contain spherical synaptic vesicles." [NIF_Subcellular:nlx_subcell_100207]
xref: NIF_Subcellular:nlx_subcell_100207
is_a: GO:0043195 ! terminal bouton
created_by: pr
creation_date: 2013-02-06T10:35:12Z

[Term]
id: GO:1990028
name: intermediate voltage-gated calcium channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a calcium ion by an intermediate voltage-gated channel. An intermediate voltage-gated channel is a channel whose open state is dependent on intermediate voltage across the membrane in which it is embedded." [GOC:BHF, GOC:rl, http://en.wikipedia.org/wiki/Calcium_channel, PMID:16382099]
synonym: "R-type calcium channel" RELATED []
is_a: GO:0005245 ! voltage-gated calcium channel activity
created_by: pr
creation_date: 2013-02-06T20:55:41Z

[Term]
id: GO:1990029
name: vasomotion
namespace: biological_process
def: "The rhythmical contraction and relaxation of arterioles, observed as slow and fast waves, with frequencies of 1-2 and 10-20 cpm." [GOC:sl, PMID:14993429, PMID:15678091, PMID:1932763]
is_a: GO:0050880 ! regulation of blood vessel size
created_by: tb
creation_date: 2013-02-06T22:30:21Z

[Term]
id: GO:1990030
name: pericellular basket
namespace: cellular_component
def: "Ramification of basket cell axon surrounding cell bodies, forming the characteristic pericellular baskets from which the cell class derives its name." [NIF_Subcellular:sao413722576]
synonym: "peri cellular basket" EXACT []
synonym: "peri-cellular basket" EXACT []
xref: NIF_Subcellular:sao413722576
is_a: GO:0033267 ! axon part
created_by: pr
creation_date: 2013-02-07T12:53:54Z

[Term]
id: GO:1990031
name: pinceau fiber
namespace: cellular_component
def: "Dense plexus formed by the descending collaterals of cerebellar basket cells that wrap around a Purkinje cell axonal initial segment." [NIF_Subcellular:sao109906988]
xref: NIF_Subcellular:sao109906988
is_a: GO:0033267 ! axon part
created_by: pr
creation_date: 2013-02-07T12:56:50Z

[Term]
id: GO:1990032
name: parallel fiber
namespace: cellular_component
def: "A parallel fiber results from the bifurcation of a cerebellar granule cell axon in the molecular layer into two diametrically opposed branches, that are oriented parallel to the long axis of the folium." [ISBN:0195159551, NIF_Subcellular:nlx_330]
xref: NIF_Subcellular:nlx_330
is_a: GO:0033267 ! axon part
created_by: pr
creation_date: 2013-02-07T12:58:43Z

[Term]
id: GO:1990033
name: dendritic branch point
namespace: cellular_component
def: "The part of a dendrite where the cell projection branches, giving rise to a dendritic branch." [NIF_Subcellular:sao-1348591767]
synonym: "branch point of dendrite" EXACT []
xref: NIF_Subcellular:sao
xref: NIF_Subcellular:sao-1348591767
is_a: GO:0044463 ! cell projection part
is_a: GO:0097458 ! neuron part
relationship: part_of GO:0030425 ! dendrite
created_by: pr
creation_date: 2013-02-07T13:01:01Z

[Term]
id: GO:1990034
name: calcium ion export from cell
namespace: biological_process
def: "The directed movement of calcium ions out of a cell." [GOC:mah, PMID:2145281]
synonym: "calcium ion efflux from cell" EXACT [GOC:vw, PMID:2145281]
is_a: GO:1901660 ! calcium ion export
created_by: mah
creation_date: 2013-02-07T13:01:29Z

[Term]
id: GO:1990035
name: calcium ion import into cell
namespace: biological_process
def: "The directed movement of calcium ions from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [GOC:mah, PMID:2145281]
synonym: "calcium ion uptake into cell" EXACT [GOC:vw]
is_a: GO:0070509 ! calcium ion import
is_a: GO:0098659 ! inorganic cation import into cell
created_by: mah
creation_date: 2013-02-07T13:07:59Z

[Term]
id: GO:1990036
name: calcium ion import into sarcoplasmic reticulum
namespace: biological_process
def: "The directed movement of calcium ions into a sarcoplasmic reticulum." [GOC:BHF, PMID:17286271]
is_a: GO:0070296 ! sarcoplasmic reticulum calcium ion transport
is_a: GO:0070509 ! calcium ion import
relationship: occurs_in GO:0005737 ! cytoplasm
created_by: tb
creation_date: 2013-02-07T23:22:27Z

[Term]
id: GO:1990037
name: Lewy body core
namespace: cellular_component
def: "The center portion of a Lewy body. In Parkinson's disease, it contains a matted meshwork of filaments." [NIF_Subcellular:sao6587439252]
xref: NIF_Subcellular:sao6587439252
is_a: GO:0044424 ! intracellular part
is_a: GO:0097458 ! neuron part
relationship: part_of GO:0097413 ! Lewy body
created_by: pr
creation_date: 2013-02-08T12:56:59Z

[Term]
id: GO:1990038
name: Lewy body corona
namespace: cellular_component
def: "The periphery of a Lewy body. In Parkinson's disease, it contains spherical accumulations of filaments arranged in a loose, radiating array." [NIF_Subcellular:sao5764355747]
synonym: "halo" BROAD []
xref: NIF_Subcellular:sao5764355747
is_a: GO:0044424 ! intracellular part
is_a: GO:0097458 ! neuron part
relationship: part_of GO:0097413 ! Lewy body
created_by: pr
creation_date: 2013-02-08T13:03:27Z

[Term]
id: GO:1990039
name: hypolemmal cisterna
namespace: cellular_component
def: "Specialized part of the smooth endoplasmic reticulum that closely underlies the plasma membrane, usually within 60 nm or closer." [ISBN:0195065719, NIF_Subcellular:sao1634374950]
synonym: "hypolemmal cisternae" EXACT []
xref: NIF_Subcellular:sao1634374950
is_a: GO:0097425 ! smooth endoplasmic reticulum part
created_by: pr
creation_date: 2013-02-11T15:04:56Z

[Term]
id: GO:1990040
name: sub-surface cisterna
namespace: cellular_component
def: "Specialization of the hypolemmal cisterna consisting of either single profiles or closely apposed stacks of endoplasmic reticulum in which the lumen is obliterated, lying 10-20 nm beneath the plasma membrane." [ISBN:0195065719, NIF_Subcellular:sao128470897]
synonym: "sub-surface cisternae" EXACT []
xref: NIF_Subcellular:sao128470897
is_a: GO:1990039 ! hypolemmal cisterna
created_by: pr
creation_date: 2013-02-11T15:10:47Z

[Term]
id: GO:1990042
name: glycerol dehydrogenase [NAD(P)+] activity
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which glycerol is converted into glycerone and NAD+ or NADP is reduced." [PMID:22979944]
synonym: "glycerol dehydrogenase activity, NAD or NADP as acceptor" EXACT []
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
created_by: ramab
creation_date: 2013-02-14T00:34:45Z

[Term]
id: GO:1990043
name: 5' deoxyribonuclease (pyrimidine dimer) activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage immediately 5' to pyrimidine dimers to products with 5'-phosphate." [EC:3.1.25.-, GOC:al, PMID:9708997]
is_a: GO:0033892 ! deoxyribonuclease (pyrimidine dimer) activity
created_by: pr
creation_date: 2013-02-15T12:16:51Z

[Term]
id: GO:1990044
name: protein localization to lipid particle
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location on or within a lipid particle." [GOC:sart, PMID:22505614]
synonym: "protein localisation to adiposome" EXACT []
synonym: "protein localisation to lipid body" EXACT []
synonym: "protein localisation to lipid droplet" EXACT []
synonym: "protein localisation to lipid particle" EXACT []
synonym: "protein localization to adiposome" EXACT []
synonym: "protein localization to lipid body" EXACT []
synonym: "protein localization to lipid droplet" EXACT []
is_a: GO:0033365 ! protein localization to organelle
created_by: sart
creation_date: 2013-02-15T12:40:57Z

[Term]
id: GO:1990045
name: sclerotium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the sclerotium over time, from its formation to the mature structure. A sclerotium is a mycelial resting body, resistant to adverse environmental conditions." [GOC:di, PMID:21148914]
is_a: GO:0043581 ! mycelium development
created_by: pr
creation_date: 2013-02-15T15:30:00Z

[Term]
id: GO:1990046
name: stress-induced mitochondrial fusion
namespace: biological_process
def: "Merging of two or more mitochondria within a cell to form a single compartment, as a result of a disturbance in cellular homeostasis." [GOC:lb, PMID:19360003]
synonym: "mitochondrial fusion in response to stress" RELATED []
synonym: "SIMH" NARROW []
synonym: "stress-induced mitochondrial hyperfusion" NARROW []
is_a: GO:0008053 ! mitochondrial fusion
is_a: GO:0033554 ! cellular response to stress
created_by: pr
creation_date: 2013-02-15T16:01:55Z

[Term]
id: GO:1990047
name: spindle matrix
namespace: cellular_component
def: "A proteinaceous, nuclear-derived structure that embeds the microtubule spindle apparatus from pole to pole in a microtubule-independent manner during mitosis." [GOC:ans, PMID:19273613, PMID:22855526]
is_a: GO:0044430 ! cytoskeletal part
created_by: pr
creation_date: 2013-02-18T08:51:47Z

[Term]
id: GO:1990048
name: anterograde dense core granule trafficking
namespace: biological_process
def: "The directed movement of substances in dense core granules along axonal microtubules towards the presynapse." [GOC:kmv, PMID:23358451]
subset: goslim_synapse
synonym: "anterograde dense core granule transport" EXACT []
is_a: GO:0008089 ! anterograde axonal transport
is_a: GO:0047496 ! vesicle transport along microtubule
is_a: GO:0099519 ! dense core granule cytoskeletal trafficking
relationship: occurs_in GO:1904115 ! axon cytoplasm
created_by: pr

[Term]
id: GO:1990049
name: retrograde dense core granule trafficking
namespace: biological_process
def: "The directed movement of dense core granules along axonal microtubules towards the cell body." [GOC:kmv, PMID:23358451, PMID:24762653]
subset: goslim_synapse
synonym: "retrograde dense core granule transport" EXACT []
is_a: GO:0008090 ! retrograde axonal transport
is_a: GO:0047496 ! vesicle transport along microtubule
is_a: GO:0099519 ! dense core granule cytoskeletal trafficking
relationship: occurs_in GO:1904115 ! axon cytoplasm
created_by: pr
creation_date: 2013-02-19T13:31:44Z

[Term]
id: GO:1990050
name: phosphatidic acid transporter activity
namespace: molecular_function
def: "Enables the directed movement of phosphatidic acid into, out of or within a cell, or between cells. Phosphatidic acid refers to a glycophospholipids with, in general, a saturated fatty acid bonded to carbon-1, an unsaturated fatty acid bonded to carbon-2, and a phosphate group bonded to carbon-3." [PMID:23042293]
is_a: GO:0005548 ! phospholipid transporter activity
created_by: ramab
creation_date: 2013-02-21T00:45:28Z

[Term]
id: GO:1990051
name: activation of protein kinase C activity
namespace: biological_process
def: "Any process that initiates the activity of the inactive enzyme protein kinase C." [PMID:3156004]
synonym: "PKC activation" EXACT []
synonym: "protein kinase C activation" EXACT []
is_a: GO:0032147 ! activation of protein kinase activity
created_by: sl
creation_date: 2013-02-21T19:57:54Z

[Term]
id: GO:1990052
name: ER to chloroplast lipid transport
namespace: biological_process
def: "The directed movement of a lipid from the endoplasmic reticulum (ER) to the chloroplast." [PMID:18689504]
synonym: "endoplasmic reticulum to chloroplast lipid transport" EXACT []
synonym: "ER to chloroplast lipid trafficking" EXACT []
is_a: GO:0032365 ! intracellular lipid transport
is_a: GO:1901965 ! endoplasmic reticulum to chloroplast transport
created_by: tb
creation_date: 2013-02-22T00:05:23Z

[Term]
id: GO:1990053
name: DNA-5-methylcytosine glycosylase activity
namespace: molecular_function
def: "Catalysis of the reaction: DNA containing 5-methylcytosine + H2O = DNA with abasic site + 5-methylcytosine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the DNA 5-methylcytosine and the deoxyribose sugar to remove the 5-methylcytosine, leaving an abasic site." [PMID:23316050]
is_a: GO:0003905 ! alkylbase DNA N-glycosylase activity
created_by: tb
creation_date: 2013-02-22T01:09:06Z

[Term]
id: GO:1990054
name: response to temozolomide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temozolomide stimulus." [GOC:hp]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: pr
creation_date: 2013-02-22T10:09:44Z

[Term]
id: GO:1990055
name: phenylacetaldehyde synthase activity
namespace: molecular_function
def: "Catalyzes the reaction: L-phenylalanine + O2 + H2O -> phenylacetaldehyde + ammonia + hydrogen peroxide + CO2." [MetaCyc:RXN-8990, PMID:16766535, PMID:23204519]
synonym: "aromatic aldehyde synthase" BROAD []
is_a: GO:0003824 ! catalytic activity
created_by: tb
creation_date: 2013-02-25T20:22:35Z

[Term]
id: GO:1990056
name: obsolete protein kinase activity required for targeting substrate to proteasomal ubiquitin-dependent protein catabolic process
namespace: molecular_function
def: "OBSOLETE. Catalysis of the phosphorylation of an amino acid residue in a substrate protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP, thereby targeting the substrate to the proteasomal ubiquitin mediated protein catabolic process" [PMID:21098119, PMID:21993622, PMID:23264631]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "protein kinase activity required for targeting substrate to proteasomal ubiquitin-dependent protein catabolic process" EXACT []
is_obsolete: true
created_by: ramab
creation_date: 2013-02-26T21:28:08Z

[Term]
id: GO:1990057
name: obsolete cell cycle arrest in response to DNA damage stimulus
namespace: biological_process
def: "OBSOLETE. The cell cycle regulatory process in which the cell cycle is halted during one of the normal phases (G1, S, G2, M) as a result of DNA damage from environmental insults or errors during metabolism." [GOC:rph, PMID:10630641]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "cell cycle arrest in response to DNA damage stimulus" EXACT []
is_obsolete: true
created_by: rph
creation_date: 2013-03-06T13:48:44Z

[Term]
id: GO:1990058
name: fruit replum development
namespace: biological_process
def: "The process whose specific outcome is the progression of the fruit replum over time, from its formation to the mature structure. The fruit replum is a portion of fruit placenta tissue that divides a fruit into two or more chambers and develops from a replum." [PMID:23133401, PO:0025267]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0009791 ! post-embryonic development
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0010154 ! fruit development
created_by: dhl
creation_date: 2013-03-12T21:15:15Z

[Term]
id: GO:1990059
name: fruit valve development
namespace: biological_process
def: "The process whose specific outcome is the progression of the fruit valve over time, from its formation to the mature structure. The fruit valve is a part of a fruit that splits apart when the fruit dehisces." [PMID:23133401, PO:0000033]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0009791 ! post-embryonic development
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0010154 ! fruit development
created_by: dhl
creation_date: 2013-03-12T21:21:15Z

[Term]
id: GO:1990060
name: maltose transport complex
namespace: cellular_component
def: "Protein complex facilitating ATP-dependent maltose transport through inner cell membrane (periplasm to cytoplasm) in Gram-negative bacteria. In E. coli the system is composed of a periplasmic maltose-binding protein (MBP), two integral membrane proteins, MalF and MalG, and two copies of the cytoplasmic ATP-binding cassette MalK." [PMID:18033289]
synonym: "maltose ABC transporter complex" EXACT []
synonym: "maltose ATP-binding cassette transporter complex" EXACT []
is_a: GO:0043190 ! ATP-binding cassette (ABC) transporter complex
relationship: part_of GO:0005887 ! integral component of plasma membrane
created_by: jl
creation_date: 2013-03-13T13:52:48Z

[Term]
id: GO:1990061
name: bacterial degradosome
namespace: cellular_component
def: "The degradosome is a protein complex playing a key role in mRNA degradation and RNA processing. It includes a RNA helicase, a 3'-5' phosphate-dependent PNPase and a RNase E bound-enolase." [GOC:bhm, PMID:21805185]
is_a: GO:0000177 ! cytoplasmic exosome (RNase complex)
is_a: GO:0044445 ! cytosolic part
relationship: part_of GO:0005829 ! cytosol
created_by: bhm
creation_date: 2013-03-20T13:51:49Z

[Term]
id: GO:1990062
name: RPAP3/R2TP/prefoldin-like complex
namespace: cellular_component
def: "A protein complex first characterized in human and comprised of a R2TP module (R2TP complex), a prefoldin-like module (containing both prefoldin-like proteins and canonical prefoldins), WD40 repeat protein Monad/WDR92 and DNA-dependent RNA polymerase subunit RPB5. This complex might have chaperone activity." [GOC:pr, PMID:20453924, PMID:21925213, PMID:22418846]
synonym: "R2TP/prefoldin-like complex" RELATED []
is_a: GO:0043234 ! protein complex
created_by: pr
creation_date: 2013-03-20T15:31:12Z

[Term]
id: GO:1990063
name: Bam protein complex
namespace: cellular_component
def: "Protein complex which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. In E. coli it is composed of BamABCDE, of the outer membrane protein BamA, and four lipoproteins BamB, BamC, BamD and BamE. BamA interacts directly with BamB and the BamCDE subcomplex." [GOC:bhm, PMID:20378773]
synonym: "OMP complex" EXACT []
is_a: GO:0044462 ! external encapsulating structure part
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0031246 ! intrinsic component of periplasmic side of cell outer membrane
created_by: bhm
creation_date: 2013-03-20T15:42:57Z

[Term]
id: GO:1990064
name: ground tissue pattern formation
namespace: biological_process
def: "The regionalization process that gives rise to the patterning of the ground tissue." [PMID:23444357]
synonym: "ground tissue patterning" EXACT []
is_a: GO:0003002 ! regionalization
created_by: tb
creation_date: 2013-03-21T23:24:44Z

[Term]
id: GO:1990065
name: Dxr protein complex
namespace: cellular_component
def: "A protein complex that is involved in the MEP pathway of IPP biosynthesis. It catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)." [GOC:bhm, PMID:15339150]
synonym: "1-deoxy-D-xylulose 5-phosphate reductoisomerase complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0005623 ! cell
created_by: bhm
creation_date: 2013-03-27T16:58:54Z

[Term]
id: GO:1990066
name: energy quenching
namespace: biological_process
def: "The process by which excess light energy absorbed by chlorophyll and not used to drive photosynthesis is emitted by nonphotochemical quenching or chlorophyll fluorescence." [PMID:10938857]
is_a: GO:0009416 ! response to light stimulus
created_by: tb
creation_date: 2013-03-27T21:02:00Z

[Term]
id: GO:1990067
name: intrachromosomal DNA recombination
namespace: biological_process
def: "The process of DNA recombination occurring within a single chromosome." [PMID:7748165]
is_a: GO:0006310 ! DNA recombination
created_by: tb
creation_date: 2013-03-27T21:11:35Z

[Term]
id: GO:1990068
name: seed dehydration
namespace: biological_process
def: "The seed development process whose outcome is the drying of a maturing seed." [PMID:20138563]
is_a: GO:0048609 ! multicellular organismal reproductive process
relationship: part_of GO:0010431 ! seed maturation
relationship: part_of GO:0048316 ! seed development
created_by: tb
creation_date: 2013-03-27T21:16:03Z

[Term]
id: GO:1990069
name: stomatal opening
namespace: biological_process
def: "The process of opening of stomata, pores in the epidermis of leaves and stems bordered by two guard cells and serving in gas exchange." [PMID:21749899]
is_a: GO:0010118 ! stomatal movement
created_by: tb
creation_date: 2013-03-27T21:18:48Z

[Term]
id: GO:1990070
name: TRAPPI protein complex
namespace: cellular_component
def: "A complex that tethers COPII vesicles at ER-Golgi intermediate compartment. Its role in this part of the vesicular transport may start at the ER exit sites. Binds to a component of the COPII coat. In yeast it includes the following subunits: Bet3 (as homodimer), Bet5, Trs20, Trs23, Trs31, Trs33 which are regarded as the \"core subunits\" of all TRAPP complexes in yeast." [GOC:bhm, PMID:20375281, PMID:22669257]
synonym: "TRAPP core complex" EXACT []
is_a: GO:0030008 ! TRAPP complex
is_a: GO:0044422 ! organelle part
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0005793 ! endoplasmic reticulum-Golgi intermediate compartment
created_by: bhm
creation_date: 2013-03-28T14:04:40Z

[Term]
id: GO:1990071
name: TRAPPII protein complex
namespace: cellular_component
def: "A complex that mediates intra-Golgi traffic, Golgi exit, endosome-to-Golgi traffic, and the trafficking of autophagy proteins from Golgi to the pre-autophagosomal structure. Binds to a component of the COPI coat. In yeast it includes the following subunits: Bet3 (as homodimer), Bet5, Tca17, Trs20, Trs23, Trs31, Trs33, Trs65, Trs120, Trs130. The whole complex is thought to dimerize with itself." [GOC:bhm, PMID:20375281, PMID:22669257]
is_a: GO:0030008 ! TRAPP complex
is_a: GO:0044431 ! Golgi apparatus part
is_a: GO:0044440 ! endosomal part
relationship: part_of GO:0005768 ! endosome
relationship: part_of GO:0005794 ! Golgi apparatus
created_by: bhm
creation_date: 2013-03-28T14:24:08Z

[Term]
id: GO:1990072
name: TRAPPIII protein complex
namespace: cellular_component
def: "A complex that functions in anterograde transport at the Golgi and also regulates autophagy. In yeast it includes at least the following subunits: Bet3 (as homodimer), Bet5, Trs20, Trs23, Trs31, Trs33, Trs85. TRAPPIII may include further, as yet undescribed, proteins." [GOC:bhm, PMID:20375281, PMID:22669257]
is_a: GO:0030008 ! TRAPP complex
is_a: GO:0044431 ! Golgi apparatus part
relationship: part_of GO:0005794 ! Golgi apparatus
created_by: bhm
creation_date: 2013-03-28T14:28:59Z

[Term]
id: GO:1990073
name: perforation plate
namespace: cellular_component
def: "A cell wall part that is the part of a wall of a vessel member and bears one or more openings (perforations)." [GOC:PO_curators, ISBN:0471245194]
comment: Part of a vessel member (PO:0002003). May be simple, with one perforation, or multiperforate, with more than one perforation. Perforation plates are usually on the end walls of a cell, but may also be on the side walls.
is_a: GO:0044426 ! cell wall part
created_by: tb
creation_date: 2013-03-29T00:53:28Z

[Term]
id: GO:1990074
name: polyuridylation-dependent mRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a messenger RNA (mRNA) molecule, initiated by the enzymatic addition of a sequence of uridylyl residues (polyuridylation) at the 3' end of the target mRNA." [GOC:vw, PMID:23503588]
is_a: GO:0006402 ! mRNA catabolic process
is_a: GO:0043632 ! modification-dependent macromolecule catabolic process
created_by: tb
creation_date: 2013-04-16T22:51:46Z

[Term]
id: GO:1990075
name: periciliary membrane compartment
namespace: cellular_component
def: "A membrane domain at the base of cilia and flagella that is enriched in endocytosis-associated proteins and vesicles and that appears to function in regulating ciliary membrane homeostasis." [GOC:dr, PMID:22342749]
synonym: "PCMC" EXACT []
is_a: GO:0031253 ! cell projection membrane
created_by: pr
creation_date: 2013-04-24T10:14:50Z

[Term]
id: GO:1990076
name: cell wall polysaccharide catabolic process involved in abscission
namespace: biological_process
def: "Any cell wall polysaccharide catabolic process that is involved in abscission." [GOC:TermGenie, PMID:23479623]
is_a: GO:0044347 ! cell wall polysaccharide catabolic process
intersection_of: GO:0044347 ! cell wall polysaccharide catabolic process
intersection_of: part_of GO:0009838 ! abscission
relationship: part_of GO:0009838 ! abscission
created_by: dhl
creation_date: 2013-04-25T16:29:43Z

[Term]
id: GO:1990077
name: primosome complex
namespace: cellular_component
def: "Any of a family of protein complexes that form at the origin of replication or stalled replication forks and function in replication primer synthesis in all organisms.  Early complexes initiate double-stranded DNA unwinding. The core unit consists of a replicative helicase and a primase. The helicase further unwinds the DNA and recruits the polymerase machinery. The primase synthesizes RNA primers that act as templates for complementary stand replication by the polymerase machinery. The primosome contains a number of associated proteins and protein complexes and contributes to the processes of replication initiation, lagging strand elongation, and replication restart." [GOC:bhm, GOC:mah, PMID:21856207]
synonym: "primosome" EXACT []
is_a: GO:0032993 ! protein-DNA complex
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0030894 ! replisome
created_by: bhm
creation_date: 2013-04-26T11:55:28Z

[Term]
id: GO:1990078
name: replication inhibiting complex
namespace: cellular_component
def: "A protein complex that inhibits multiple events of replication initiation during one replication cycle." [GOC:bhm, PMID:21708944]
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0030894 ! replisome
created_by: bhm
creation_date: 2013-04-26T13:07:03Z

[Term]
id: GO:1990079
name: cartilage homeostasis
namespace: biological_process
def: "A tissue homeostatic process involved in the maintenance of an internal equilibrium within cartilage, including control of cellular proliferation and death and control of metabolic function." [GOC:hjd, PMID:21652695]
is_a: GO:0001894 ! tissue homeostasis
created_by: hjd
creation_date: 2013-04-29T20:10:15Z

[Term]
id: GO:1990080
name: 2-phenylethylamine receptor activity
namespace: molecular_function
def: "Combining with the biogenic amine 2-phenylethylamine to initiate a change in cell activity." [PMID:16878137]
synonym: "beta-phenylethylamine receptor activity" EXACT []
is_a: GO:0008227 ! G-protein coupled amine receptor activity
created_by: sp
creation_date: 2013-04-30T10:53:19Z

[Term]
id: GO:1990081
name: trimethylamine receptor activity
namespace: molecular_function
def: "Combining with the biogenic amine trimethylamine to initiate a change in cell activity." [PMID:16878137]
is_a: GO:0001594 ! trace-amine receptor activity
created_by: sp
creation_date: 2013-04-30T10:57:07Z

[Term]
id: GO:1990082
name: DnaA-L2 complex
namespace: cellular_component
def: "A protein complex that inhibits unwinding of DNA at the origin of replication and assembly of the pre-primosome. In E. coli, this complex is composed of DnaA and of the ribosomal protein L2." [GOC:bhm, PMID:21288885]
is_a: GO:1990078 ! replication inhibiting complex
created_by: bhm
creation_date: 2013-04-30T11:46:41Z

[Term]
id: GO:1990083
name: DnaA-Hda complex
namespace: cellular_component
def: "A protein complex that inactivates the function of DnaA by inhibiting the phosphorylation of DnaA-ADP to DnaA-ATP and thereby preventing multiple events of replication initiation. In E. coli, this complex is composed of DnaA and Hda." [GOC:bhm, PMID:21708944]
is_a: GO:1990078 ! replication inhibiting complex
created_by: bhm
creation_date: 2013-04-30T11:49:04Z

[Term]
id: GO:1990084
name: DnaA-Dps complex
namespace: cellular_component
def: "A protein complex that negatively regulates strand-opening at the origin of replication, thereby interfering with replication initiation. This complex is thought to be involved in the regulation of replication under oxidative stress conditions. In E. coli, this complex is composed of DnaA and Dps." [GOC:bhm, PMID:18284581]
is_a: GO:1990078 ! replication inhibiting complex
created_by: bhm
creation_date: 2013-04-30T11:50:17Z

[Term]
id: GO:1990085
name: Hda-beta clamp complex
namespace: cellular_component
def: "A protein complex involved in inactivating the function of DnaA and thereby preventing multiple events of replication initiation. In E. coli, this complex is composed of the beta clamp (DnaN) and Hda." [GOC:bhm, PMID:15150238]
synonym: "Hda-DnaN complex" EXACT []
synonym: "Hda-dpo3b complex" EXACT []
is_a: GO:1990078 ! replication inhibiting complex
created_by: bhm
creation_date: 2013-04-30T11:53:18Z

[Term]
id: GO:1990086
name: lens fiber cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a lens fiber cell. Lens fiber cells are elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye." [CL:0011004, GOC:hjd, PMID:11095619]
is_a: GO:1904019 ! epithelial cell apoptotic process
created_by: hjd
creation_date: 2013-05-01T19:09:28Z

[Term]
id: GO:1990088
name: [methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a [methyl-Co(III) methanol-specific corrinoid protein] + coenzyme M = methyl-CoM + a [Co(I) methanol-specific corrinoid protein]." [GOC:hjd, PMID:10077852]
xref: EC:2.1.1.246
is_a: GO:0008168 ! methyltransferase activity
created_by: hjd
creation_date: 2013-05-06T15:07:20Z

[Term]
id: GO:1990089
name: response to nerve growth factor
namespace: biological_process
def: "A process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus." [PMID:22399805]
synonym: "response to nerve growth factor stimulus" EXACT [GOC:dos]
is_a: GO:0009719 ! response to endogenous stimulus
is_a: GO:0070848 ! response to growth factor
created_by: sl
creation_date: 2013-05-06T17:08:47Z

[Term]
id: GO:1990090
name: cellular response to nerve growth factor stimulus
namespace: biological_process
def: "A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus." [PMID:22399805, Wikipedia:Nerve_growth_factor]
synonym: "cellular response to NGF" EXACT [GOC:bf, Wikipedia:Nerve_growth_factor]
is_a: GO:0071363 ! cellular response to growth factor stimulus
is_a: GO:0071495 ! cellular response to endogenous stimulus
is_a: GO:1990089 ! response to nerve growth factor
created_by: sl
creation_date: 2013-05-06T17:13:36Z

[Term]
id: GO:1990091
name: sodium-dependent self proteolysis
namespace: biological_process
def: "The sodium-dependent hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their own peptide bonds." [PMID:20460380]
is_a: GO:0097264 ! self proteolysis
created_by: sl
creation_date: 2013-05-06T17:30:23Z

[Term]
id: GO:1990092
name: calcium-dependent self proteolysis
namespace: biological_process
def: "The sodium-dependent hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their own peptide bonds." [PMID:20460380]
is_a: GO:0097264 ! self proteolysis
created_by: sl
creation_date: 2013-05-06T17:33:34Z

[Term]
id: GO:1990093
name: obsolete negative regulation of N-methyl-D-aspartate receptor clustering
namespace: biological_process
def: "OBSOLETE. The negative regulation of the receptor clustering process in which N-methyl-D-aspartate (NMDA) receptors are localized to distinct domains in the cell membrane." [PMID:18442977]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "negative regulation of N-methyl-D-aspartate receptor clustering" EXACT []
synonym: "negative regulation of NMDA receptor clustering" EXACT []
is_obsolete: true
created_by: sl
creation_date: 2013-05-06T17:39:44Z

[Term]
id: GO:1990094
name: obsolete positive regulation of N-methyl-D-aspartate receptor clustering
namespace: biological_process
def: "OBSOLETE. The positive regulation of the receptor clustering process in which N-methyl-D-aspartate (NMDA) receptors are localized to distinct domains in the cell membrane." [PMID:18442977]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "positive regulation of N-methyl-D-aspartate receptor clustering" EXACT []
synonym: "positive regulation of NMDA receptor clustering" EXACT []
is_obsolete: true
created_by: sl
creation_date: 2013-05-06T17:44:00Z

[Term]
id: GO:1990095
name: positive regulation of transcription from RNA polymerase II promoter in response to reactive oxygen species
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:kmv, PMID:16166371]
is_a: GO:0036091 ! positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress
relationship: part_of GO:0034614 ! cellular response to reactive oxygen species
created_by: pr
creation_date: 2013-05-07T12:10:32Z

[Term]
id: GO:1990096
name: positive regulation of transcription from RNA polymerase II promoter in response to superoxide
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion." [GOC:kmv, PMID:12869585, PMID:16166371]
is_a: GO:1990095 ! positive regulation of transcription from RNA polymerase II promoter in response to reactive oxygen species
relationship: part_of GO:0071451 ! cellular response to superoxide
created_by: pr
creation_date: 2013-05-07T12:25:34Z

[Term]
id: GO:1990097
name: SeqA-DNA complex
namespace: cellular_component
def: "A protein-DNA complex that contains an oligomer of SeqA bound to GATC sites in methylated or newly-synthesized, hemi-methylated double-stranded DNA, with preference for the latter. Binding of SeqA to hemimethylated DNA sequesters oriC, prevents re-methylation of DNA by Dam and in turn stops premature re-initiation of replication during one replication cycle." [GOC:bhm, PMID:12379844, PMID:15933720, PMID:23149570]
synonym: "SeqA-dsDNA complex" NARROW []
synonym: "SeqA-hemimethylated DNA complex" NARROW []
synonym: "SeqA-hemimethylation dsDNA complex" NARROW []
is_a: GO:0032993 ! protein-DNA complex
created_by: bhm
creation_date: 2013-05-13T11:18:11Z

[Term]
id: GO:1990098
name: core primosome complex
namespace: cellular_component
def: "A protein-DNA complex containing at least one DNA helicase and one primase. Can also contain associated proteins. The helicase component continues to unwind the double-stranded DNA (dsDNA) and the primase component synthesizes a RNA primer during initiation or restart of replication." [GOC:bhm, PMID:21856207]
comment: The core primosome refers to a helicase-primase complex, and should not be confused with the more general GO term 'primosome complex ; GO:1990077'.
synonym: "core primosome" EXACT [GOC:bhm]
is_a: GO:1990077 ! primosome complex
created_by: bhm
creation_date: 2013-05-14T10:30:02Z

[Term]
id: GO:1990099
name: pre-primosome complex
namespace: cellular_component
def: "Any of the protein-DNA complexes that contain a DNA helicase and associated protein(s) at the origin of replication, and build up to assembling the core primosome. The associated protein(s) chaperone the helicase to the DNA, and assembly of the pre-primosome is essential for the initiation or restart of replication. Pre-primosome complexes lack a primase component." [GOC:bhm, PMID:18179598, PMID:20129058, PMID:8663105]
synonym: "pre-priming complex" EXACT [GOC:bhm]
synonym: "pre-primosome" EXACT [GOC:bhm, PMID:11994158]
synonym: "pre-replication complex" RELATED [GOC:bhm]
synonym: "preprimosome" EXACT [GOC:bhm, PMID:2824502]
synonym: "preprimosome complex" EXACT [GOC:bhm]
synonym: "prereplication complex" EXACT [GOC:bhm]
is_a: GO:1990077 ! primosome complex
created_by: bhm
creation_date: 2013-05-14T10:53:42Z

[Term]
id: GO:1990100
name: DnaB-DnaC complex
namespace: cellular_component
def: "A protein complex containing homohexameric DNA helicase DnaB, and the DNA helicase loader DnaC. The helicase loader DnaC delivers DnaB to the chromosomal origin (oriC)." [GOC:bhm, PMID:20129058]
comment: DnaB and DnaC may be present in different ratios in different forms of the DnaB-DnaC complex, including a DnaB6-DnaC3 complex active at the oriC, and a DnaB6-DnaC6 complex.
synonym: "DnaB6-DnaC3 complex" NARROW [PMID:20129058]
synonym: "DnaB6-DnaC6 complex" NARROW [PMID:20129058]
synonym: "helicase-loading complex" BROAD [GOC:bhm]
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
relationship: has_part GO:1990161 ! DnaB helicase complex
relationship: part_of GO:1990077 ! primosome complex
created_by: bhm
creation_date: 2013-05-14T12:02:22Z

[Term]
id: GO:1990101
name: DnaA-oriC complex
namespace: cellular_component
def: "A protein-DNA complex containing the initiator protein DnaA bound to high-affinity recognition sites in the unique origin of replication, oriC. DnaA-oriC binding is the first step in assembly of a bacterial pre-replicative complex (pre-RC) and is responsible for the timely initiation of replication once per cell cycle." [GOC:bhm, PMID:19833870]
synonym: "DnaA-DNA complex" BROAD [GOC:bhm]
is_a: GO:1990077 ! primosome complex
created_by: bhm
creation_date: 2013-05-14T12:07:04Z

[Term]
id: GO:1990102
name: DnaA-DiaA complex
namespace: cellular_component
def: "A protein-DNA complex containing a tetramer of DiaA attached to multiple  DnaA molecule bound to oriC DNA. Regulates timely initiation of chromosomal replication during the cell cycle by stimulating assembly of DnaA-oriC complexes, conformational changes in ATP-DnaA initiation complexes, and unwinding of oriC duplex DNA." [GOC:bhm, PMID:15326179, PMID:17699754]
synonym: "DnaA-DiaA-DNA complex" EXACT [GOC:bhm]
is_a: GO:1990077 ! primosome complex
relationship: has_part GO:1990101 ! DnaA-oriC complex
relationship: has_part GO:1990125 ! DiaA complex
created_by: bhm
creation_date: 2013-05-14T12:33:59Z

[Term]
id: GO:1990103
name: DnaA-HU complex
namespace: cellular_component
def: "A protein-DNA complex containing DNA-bound DnaA attached to HU. HU is a dimer encoded by two closely related genes. Essential for the initiation of replication in bacteria; stimulates the DnaA-dependent unwinding of oriC." [GOC:bhm, PMID:18179598]
synonym: "DnaA-HU-DNA complex" EXACT [GOC:bhm]
is_a: GO:1990077 ! primosome complex
created_by: bhm
creation_date: 2013-05-14T12:36:39Z

[Term]
id: GO:1990104
name: DNA bending complex
namespace: cellular_component
def: "A protein-DNA complex that contains DNA in combination with a protein which binds to and bends DNA. Often plays a role in DNA compaction." [GOC:bhm, PMID:17097674]
synonym: "histone-like DNA binding complex" NARROW [GOC:bhm]
is_a: GO:0043234 ! protein complex
created_by: bhm
creation_date: 2013-05-20T09:29:06Z

[Term]
id: GO:1990105
name: obsolete regulation of voltage-gated potassium channel activity
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of voltage-gated potassium channel activity." [PMID:19219384]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "regulation of voltage-gated potassium channel activity" EXACT []
is_obsolete: true
created_by: sl
creation_date: 2013-05-21T15:12:06Z

[Term]
id: GO:1990107
name: thiazole synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + thiocarboxy-adenylate-[sulfur-carrier protein ThiS] = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS] + 2 H2O." [EC:2.8.1.10, GOC:cjk, PMID:22031445, RHEA:26300]
comment: H2S can provide the sulfur in vitro. Part of the pathway for thiamine biosynthesis.
synonym: "1-deoxy-D-xylulose 5-phosphate:thiol sulfurtransferase activity" EXACT []
is_a: GO:0016783 ! sulfurtransferase activity
relationship: part_of GO:0009228 ! thiamine biosynthetic process
created_by: pr
creation_date: 2013-05-28T12:36:04Z

[Term]
id: GO:1990108
name: protein linear deubiquitination
namespace: biological_process
def: "A protein deubiquitination process in which a linear polymer of ubiquitin, formed by the amino-terminal methionine (M1) of one ubiquitin molecule and by the carboxy-terminal glycine (G76) of the next, is removed from a protein." [PMID:23708998]
is_a: GO:0016579 ! protein deubiquitination
created_by: sp
creation_date: 2013-05-29T05:58:49Z

[Term]
id: GO:1990109
name: rejection of pollen from other species
namespace: biological_process
def: "The process involved in the rejection of pollen of one species by cells in the stigma of another species." [PMID:21205670]
synonym: "unilateral interspecific incompatibility" EXACT []
is_a: GO:0044419 ! interspecies interaction between organisms
is_a: GO:0044703 ! multi-organism reproductive process
relationship: part_of GO:0009875 ! pollen-pistil interaction
created_by: tb
creation_date: 2013-05-29T21:12:09Z

[Term]
id: GO:1990110
name: callus formation
namespace: biological_process
def: "The process by which a callus is formed at a wound site. A plant callus is a portion of plant tissue that consists of mass of undifferentiated plant cells. It consists primarily of parenchyma cells but possibly contains other cell types as the callus begins to differentiate." [ISBN:0070187517]
is_a: GO:0044707 ! single-multicellular organism process
relationship: part_of GO:0042060 ! wound healing
created_by: tb
creation_date: 2013-05-29T22:02:52Z

[Term]
id: GO:1990111
name: spermatoproteasome complex
namespace: cellular_component
def: "A proteasome specifically found in mammalian testis. Contains the proteasome activator PA200 in the regulatory particle, and beta1i, beta2i, beta5i and/or alpha4s in the core (20S) subunit. Beta1i, beta2i and beta5i are inducible catalytic subunits, closely related to beta1, beta2 and beta5. Alpha4s is a sperm-specific 20S subunit, but unlike other alternative 20S subunits alpha4s lies in the outer alpha-ring and lacks catalytic activity." [GOC:sp, PMID:23706739]
is_a: GO:0000502 ! proteasome complex
created_by: sp
creation_date: 2013-05-31T11:56:52Z

[Term]
id: GO:1990112
name: RQC complex
namespace: cellular_component
def: "A multiprotein complex that forms a stable complex with 60S ribosomal subunits containing stalled polypeptides and triggers their degradation (ribosomal quality control). In budding yeast, this complex includes Cdc48p, Rkr1p, Tae2p, Rqc1p, Npl4p and Ufd1p proteins." [GOC:rb, PMID:23178123, PMID:23232563]
synonym: "ribosome quality control complex" EXACT [PMID:23178123, PMID:23232563]
synonym: "ribosome-bound quality control complex" EXACT []
is_a: GO:0043234 ! protein complex
created_by: rb
creation_date: 2013-05-31T21:42:43Z

[Term]
id: GO:1990113
name: RNA Polymerase I assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the eukaryotic RNA polymerase I complex." [GOC:rb, PMID:23459708]
synonym: "DNA-directed RNA polymerase I complex assembly" EXACT []
synonym: "RNA Polymerase I complex assembly" EXACT []
is_a: GO:0043623 ! cellular protein complex assembly
created_by: rb
creation_date: 2013-05-31T21:44:41Z

[Term]
id: GO:1990114
name: RNA Polymerase II core complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the eukaryotic RNA polymerase II core complex." [GOC:rb, PMID:23459708]
synonym: "DNA-directed RNA polymerase II, core complex assembly" EXACT []
synonym: "RNA Polymerase II assembly" BROAD []
is_a: GO:0043623 ! cellular protein complex assembly
created_by: rb
creation_date: 2013-05-31T21:46:42Z

[Term]
id: GO:1990115
name: RNA Polymerase III assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the eukaryotic RNA polymerase III complex." [GOC:rb, PMID:23459708]
synonym: "DNA-directed RNA polymerase III complex assembly" EXACT []
synonym: "RNA Polymerase III complex assembly" EXACT []
is_a: GO:0043623 ! cellular protein complex assembly
created_by: rb
creation_date: 2013-05-31T21:49:19Z

[Term]
id: GO:1990116
name: ribosome-associated ubiquitin-dependent protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide encoded by an aberrant message and associated with a stalled ribosome. Degradation is initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the ribosome-associated protein." [GOC:dgf, PMID:23358411]
synonym: "RAD" BROAD []
synonym: "ribosome-associated degradation" BROAD []
synonym: "ribosome-associated ubiquitin-dependent protein breakdown" EXACT []
synonym: "ribosome-associated ubiquitin-dependent protein catabolism" EXACT []
synonym: "ribosome-associated ubiquitin-dependent protein degradation" EXACT []
is_a: GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process
created_by: pr
creation_date: 2013-06-05T11:46:01Z

[Term]
id: GO:1990117
name: B cell receptor apoptotic signaling pathway
namespace: biological_process
def: "An extrinsic apoptotic signaling pathway initiated by the cross-linking of an antigen receptor on a B cell." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, PMID:15214043]
synonym: "B cell receptor extrinsic apoptotic signaling pathway" EXACT []
synonym: "extrinsic apoptotic signaling pathway via B cell antigen receptor" RELATED []
synonym: "extrinsic apoptotic signaling pathway via BCR" RELATED []
is_a: GO:0050853 ! B cell receptor signaling pathway
is_a: GO:0097191 ! extrinsic apoptotic signaling pathway
relationship: part_of GO:0001783 ! B cell apoptotic process
created_by: pr
creation_date: 2013-06-06T15:15:17Z

[Term]
id: GO:1990118
name: sodium ion import into cell
namespace: biological_process
def: "The directed movement of sodium ions from outside of a cell into the intracellular region of a cell." [GOC:al, PMID:14674689]
is_a: GO:0097369 ! sodium ion import
created_by: pr
creation_date: 2013-06-09T07:21:26Z

[Term]
id: GO:1990119
name: ATP-dependent RNA helicase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of ATP-dependent RNA helicase." [GOC:rb, PMID:23721653]
is_a: GO:0042030 ! ATPase inhibitor activity
relationship: negatively_regulates GO:0004004 ! ATP-dependent RNA helicase activity
created_by: rb
creation_date: 2013-06-11T21:14:38Z

[Term]
id: GO:1990120
name: messenger ribonucleoprotein complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins and messenger RNA (mRNA) molecules to form a messenger ribonucleoprotein (mRNP) complex." [GOC:rb, PMID:23721653]
synonym: "messenger ribonucleoprotein assembly" RELATED []
synonym: "mRNA-protein complex assembly" EXACT [GOC:bf]
synonym: "mRNP assembly" EXACT [GOC:rb]
synonym: "mRNP complex assembly" EXACT [GOC:bf]
is_a: GO:0022618 ! ribonucleoprotein complex assembly
created_by: rb
creation_date: 2013-06-11T21:18:20Z

[Term]
id: GO:1990121
name: H-NS complex
namespace: cellular_component
def: "A multimer of H-NS proteins that is involved in bacterial nucleoid condensation and negative regulation of global gene expression by directly binding to promoter regions. Recognizes both structural and sequence-specific motifs in double-stranded DNA and has binding preference for bent DNA." [GOC:bhm, PMID:12592399]
synonym: "DNA-binding protein H-NS complex" EXACT []
synonym: "histone-like protein H-NS complex" EXACT []
is_a: GO:0044422 ! organelle part
is_a: GO:0044445 ! cytosolic part
is_a: GO:1990104 ! DNA bending complex
relationship: part_of GO:0043590 ! bacterial nucleoid
created_by: bhm
creation_date: 2013-06-12T10:08:31Z

[Term]
id: GO:1990122
name: leucine import into cell
namespace: biological_process
def: "The directed movement of leucine from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [GOC:mah, PMID:1356078]
synonym: "L-leucine import into cell" NARROW [GOC:mah]
is_a: GO:0060356 ! leucine import
is_a: GO:1902837 ! amino acid import into cell
created_by: mah
creation_date: 2013-06-12T12:27:47Z

[Term]
id: GO:1990123
name: L-glutamate import into cell
namespace: biological_process
def: "The directed movement of L-glutamate from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [GOC:mah, PMID:1356078]
is_a: GO:1902837 ! amino acid import into cell
is_a: GO:1903802 ! L-glutamate(1-) import into cell
created_by: mah
creation_date: 2013-06-12T12:32:47Z

[Term]
id: GO:1990124
name: messenger ribonucleoprotein complex
namespace: cellular_component
def: "A ribonucleoprotein complex containing both protein and messenger RNA (mRNA) molecules." [GOC:bf, PMID:15574591, PMID:21915786]
synonym: "messenger ribonucleoprotein particle" RELATED [PMID:21915786]
synonym: "mRNA-protein complex" EXACT [PMID:21915786]
synonym: "mRNP" EXACT [PMID:21915786]
synonym: "mRNP complex" EXACT [PMID:15574591, PMID:21915786]
is_a: GO:0030529 ! intracellular ribonucleoprotein complex
created_by: bf
creation_date: 2013-06-13T09:20:52Z

[Term]
id: GO:1990125
name: DiaA complex
namespace: cellular_component
def: "A homotetrameric protein complex consisting of a symmetrical pair of DiaA homodimers. Facilitates DnaA binding to the origin of replication during replication initiation." [GOC:bhm, PMID:17699754]
synonym: "DiaA homotetramer" EXACT [GOC:bf, PMID:17699754]
is_a: GO:0043234 ! protein complex
created_by: bhm
creation_date: 2013-06-13T14:03:54Z

[Term]
id: GO:1990126
name: retrograde transport, endosome to plasma membrane
namespace: biological_process
def: "The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins." [PMID:23563491]
is_a: GO:0016192 ! vesicle-mediated transport
is_a: GO:0016197 ! endosomal transport
created_by: sp
creation_date: 2013-06-18T10:52:50Z

[Term]
id: GO:1990127
name: intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator
namespace: biological_process
def: "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of osmotic stress, and ends when the execution phase of apoptosis is triggered." [GOC:krc, GOC:mtg_apoptosis, PMID:16571598]
is_a: GO:0008627 ! intrinsic apoptotic signaling pathway in response to osmotic stress
is_a: GO:0072332 ! intrinsic apoptotic signaling pathway by p53 class mediator
created_by: pr
creation_date: 2013-06-19T13:55:06Z

[Term]
id: GO:1990128
name: obsolete pre-primosome complex involved in replication initiation
namespace: cellular_component
def: "OBSOLETE. A protein-DNA complex involved in replication initiation at the origin of replication." [GOC:bhm, PMID:21856207]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "pre-primosome complex involved in replication initiation" EXACT []
is_obsolete: true
created_by: bhm
creation_date: 2013-06-24T10:29:39Z

[Term]
id: GO:1990129
name: obsolete pre-primosome complex involved in replication restart
namespace: cellular_component
def: "OBSOLETE. A protein-DNA complex involved in replication restart after a stalled replication fork has been repaired." [GOC:bhm, PMID:17139333]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "pre-primosome complex involved in replication restart" EXACT []
is_obsolete: true
created_by: bhm
creation_date: 2013-06-24T10:36:30Z

[Term]
id: GO:1990130
name: Iml1 complex
namespace: cellular_component
def: "A protein complex involved in regulation of non-nitrogen-starvation (NNS) autophagic process. In S. cerevisiae this complex contains Iml1p, Npr2p and Npr3p proteins. In humans the GATOR1 complex consists of DEPDC5, Nprl2, Nprl3." [GOC:rb, PMID:21900499, PMID:23974112]
synonym: "GATOR1 complex" EXACT []
synonym: "SEACIT complex" EXACT []
is_a: GO:0043234 ! protein complex
relationship: part_of GO:0035859 ! Seh1-associated complex
created_by: rb
creation_date: 2013-06-25T17:34:40Z

[Term]
id: GO:1990131
name: Gtr1-Gtr2 GTPase complex
namespace: cellular_component
def: "A heterodimer GTPase complex. In S. cerevisiae, this complex contains Gtr1p and Gtr2p proteins." [GOC:rb, PMID:10388807, PMID:16143306]
is_a: GO:0043234 ! protein complex
created_by: rb
creation_date: 2013-06-25T20:39:16Z

[Term]
id: GO:1990132
name: obsolete release of misfolded protein from chaperone
namespace: biological_process
def: "OBSOLETE. The release of misfolded proteins that are being held by the chaperone heat shock protein (Hsp) and targeting them for destruction by the Ub-proteasome machinery." [GOC:rb, PMID:23530227]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
synonym: "release of misfolded protein from chaperone" EXACT []
is_obsolete: true
created_by: rb
creation_date: 2013-06-25T21:56:37Z

[Term]
id: GO:1990133
name: molybdopterin cofactor (Moco) biosynthesis adenylyltransferase complex
namespace: cellular_component
def: "A heterodimeric protein complex which adenylates two molecules of the sulfur carrier subunit of the molybdopterin (MPT) cofactor synthase using ATP as part of molybdopterin cofactor (Moco) biosynthesis. In E. coli the subunits are MoeB and MoaD; Moco biosynthesis and its constituent molecules are evolutionarily conserved." [GOC:bhm, pmid:11713534, pmid:16669776]
is_a: GO:0044445 ! cytosolic part
is_a: GO:1902503 ! adenylyltransferase complex
relationship: part_of GO:0005829 ! cytosol
created_by: bhm
creation_date: 2013-06-26T10:54:21Z

[Term]
id: GO:1990134
name: epithelial cell apoptotic process involved in palatal shelf morphogenesis
namespace: biological_process
def: "An apoptotic process in a palatal shelf epithelial cell that contributes to the shaping of the palatal shelf." [GOC:dph, GOC:mtg_apoptosis, PMID:16607638]
is_a: GO:0060561 ! apoptotic process involved in morphogenesis
is_a: GO:1904019 ! epithelial cell apoptotic process
relationship: part_of GO:0060021 ! palate development
created_by: dph
creation_date: 2013-06-26T11:56:00Z

[Term]
id: GO:1990135
name: flavonoid sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a flavonoid + 3'-phosphoadenosine-5'-phosphosulfate = sulfated flavonoid + adenosine-3',5'-diphosphate. This reaction is the transfer of a sulfate group to the hydroxyl group of a flavonoid acceptor, producing the sulfated flavonoid derivative." [PMID:23611783]
is_a: GO:0008146 ! sulfotransferase activity
created_by: tb
creation_date: 2013-06-28T22:07:27Z

[Term]
id: GO:1990136
name: linoleate 9S-lipoxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: linoleate + O2 = (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate." [EC:1.13.11.58, GOC:rph, RHEA:30294]
synonym: "9-lipoxygenase activity" RELATED []
synonym: "9S-lipoxygenase activity" RELATED []
synonym: "linoleate 9-lipoxygenase activity" RELATED []
synonym: "linoleate:oxygen 9S-oxidoreductase activity" EXACT []
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
created_by: pr
creation_date: 2013-07-03T12:20:57Z

[Term]
id: GO:1990137
name: plant seed peroxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: R1H + R2OOH = R1OH + R2OH." [PMID:19467604]
synonym: "peroxygenase activity" RELATED [PMID:19467604]
xref: EC:1.11.2.3
xref: MetaCyc:RXN-11819
is_a: GO:0016684 ! oxidoreductase activity, acting on peroxide as acceptor
created_by: tb
creation_date: 2013-07-03T12:49:20Z

[Term]
id: GO:1990138
name: neuron projection extension
namespace: biological_process
def: "Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:BHF, GOC:rl, PMID:22790009]
synonym: "neurite extension" NARROW []
synonym: "neuron process extension" EXACT []
synonym: "neuron protrusion extension" EXACT []
synonym: "neuronal cell projection extension" EXACT []
is_a: GO:0048588 ! developmental cell growth
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0048812 ! neuron projection morphogenesis
created_by: pr
creation_date: 2013-07-08T08:40:45Z

[Term]
id: GO:1990139
name: protein localization to nuclear periphery
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within the nuclear periphery." [GOC:mah, PMID:23703609]
is_a: GO:0034504 ! protein localization to nucleus
created_by: mah
creation_date: 2013-07-09T13:35:49Z

[Term]
id: GO:1990140
name: MPT synthase complex
namespace: cellular_component
def: "A heterodimeric protein complex which catalyses sulfur transfer from the sulfur carrier subunit of MPT synthase to precursor Z to synthesize MPT as part of molybdopterin cofactor (Moco) biosynthesis. In E. coli the subunits are MoaE and MoaD; in human, MOCS2B and MOCS2A. Moco biosynthesis and its constituent molecules are evolutionarily conserved." [GOC:bhm, PMID:11135669, PMID:16669776, Reactome:REACT_25073.1]
synonym: "molybdopterin cofactor (Moco) biosynthesis sulfurtransferase complex" RELATED []
is_a: GO:1990228 ! sulfurtransferase complex
relationship: part_of GO:0005829 ! cytosol
created_by: pr
creation_date: 2013-07-11T08:32:29Z

[Term]
id: GO:1990141
name: chromatin silencing at centromere outer repeat region
namespace: biological_process
def: "Repression of transcription of DNA at the outer repeat region of a regional centromere by altering the structure of chromatin." [PMID:21847092]
synonym: "chromatin silencing at pericentric region" RELATED [GOC:mah]
is_a: GO:0030702 ! chromatin silencing at centromere
intersection_of: GO:0006342 ! chromatin silencing
intersection_of: occurs_in GO:0034507 ! chromosome, centromeric outer repeat region
relationship: occurs_in GO:0034507 ! chromosome, centromeric outer repeat region
created_by: mah
creation_date: 2013-07-17T15:21:38Z

[Term]
id: GO:1990142
name: envenomation resulting in hemolysis in other organism
namespace: biological_process
def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with hemolysis in the bitten organism." [PMID:21590705]
is_a: GO:0044649 ! envenomation resulting in cytolysis in other organism
created_by: sp
creation_date: 2013-07-18T10:46:03Z

[Term]
id: GO:1990143
name: CoA-synthesizing protein complex
namespace: cellular_component
def: "A multisubunit complex likely involved in the synthesis of coenzyme A (CoA). In S. cerevisiae, the complex consists of at least Cab2, Cab3, Cab4 and Cab5 but may also include Sis2 and Vhs3. The latter subunits are shared by the GO:0071513 phosphopantothenoylcysteine decarboxylase complex that catalyses the third step of the coenzyme A (CoA) biosynthetic pathway." [GOC:rb, PMID:23789928]
synonym: "CoA-SPC" EXACT []
synonym: "coenzyme A-synthesizing protein complex" EXACT []
is_a: GO:0043234 ! protein complex
created_by: rb
creation_date: 2013-07-18T22:30:20Z

[Term]
id: GO:1990144
name: intrinsic apoptotic signaling pathway in response to hypoxia
namespace: biological_process
def: "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to hypoxia (lowered oxygen tension). Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. The pathway ends when the execution phase of apoptosis is triggered." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, PMID:20436456]
is_a: GO:0097193 ! intrinsic apoptotic signaling pathway
relationship: part_of GO:0071456 ! cellular response to hypoxia
created_by: pr
creation_date: 2013-07-23T10:18:10Z

[Term]
id: GO:1990145
name: maintenance of translational fidelity
namespace: biological_process
def: "Suppression of the occurrence of translational errors, such as codon-anticodon mis-paring, during the process of translation of a protein using an mRNA template." [GOC:hjd, ISBN:9781936113460, PMID:21841312]
is_a: GO:0009059 ! macromolecule biosynthetic process
relationship: part_of GO:0006412 ! translation
created_by: hjd
creation_date: 2013-07-24T19:30:09Z

[Term]
id: GO:1990146
name: protein localization to rhabdomere
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a rhabdomere." [GOC:sart, PMID:8335687]
is_a: GO:0034613 ! cellular protein localization
created_by: sart
creation_date: 2013-07-25T11:24:49Z

[Term]
id: GO:1990147
name: talin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a talin, a family of related cytoskeletal proteins that play a role in assembly of actin filaments and migration of various cell types." [GOC:hjd, PMID:23372168]
is_a: GO:0008092 ! cytoskeletal protein binding
created_by: hjd
creation_date: 2013-07-25T19:49:53Z

[Term]
id: GO:1990148
name: glutamate dehydrogenase complex
namespace: cellular_component
def: "A homomeric protein complex that possesses glutamate dehydrogenase activity. This complex is evolutionarily conserved except that the number of homoprotomers per complex varies." [GOC:bhm, PMID:22393408, PMID:23412807]
synonym: "dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate)) complex" RELATED []
synonym: "glutamate dehydrogenase (NADP+) complex" RELATED []
synonym: "glutamic acid dehydrogenase complex" RELATED []
synonym: "glutamic dehydrogenase complex" RELATED []
synonym: "L-glutamate dehydrogenase complex" RELATED []
synonym: "L-glutamate:NADP+ oxidoreductase (deaminating) complex" RELATED []
synonym: "L-glutamic acid dehydrogenase complex" RELATED []
synonym: "NAD(P)-glutamate dehydrogenase complex" RELATED []
synonym: "NAD(P)H-dependent glutamate dehydrogenase complex" RELATED []
is_a: GO:1990204 ! oxidoreductase complex
created_by: pr
creation_date: 2013-07-26T10:14:15Z

[Term]
id: GO:1990149
name: obsolete COPI vesicle coating
namespace: biological_process
def: "OBSOLETE. The addition of COPI proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat." [GOC:rb, PMID:11970962]
comment: This term was obsoleted at the TermGenie Gatekeeper stage because COPI vesicles are formed on Golgi membranes, and the existing term 'COPI coating of Golgi vesicle ; GO:0048205' describes this process.
synonym: "COPI vesicle coating" EXACT []
is_obsolete: true
created_by: rb
creation_date: 2013-07-29T22:09:37Z

[Term]
id: GO:1990150
name: VEGF-A complex
namespace: cellular_component
def: "A homodimeric, extracellular protein complex containing two VEGF-A monomers. Binds to and activates a receptor tyrosine kinase." [GOC:bf, GOC:bhm, PMID:12207021, PMID:19658168]
synonym: "vascular endothelial growth factor A complex" EXACT [GOC:bhm]
is_a: GO:0036454 ! growth factor complex
is_a: GO:0044421 ! extracellular region part
created_by: bhm
creation_date: 2013-07-30T13:24:41Z

[Term]
id: GO:1990151
name: protein localization to cell tip
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location at the cell tip." [PMID:22768263]
synonym: "protein localisation to cell tip" EXACT [GOC:mah]
is_a: GO:0034613 ! cellular protein localization
created_by: mah
creation_date: 2013-07-31T14:56:40Z

[Term]
id: GO:1990152
name: protein localization to telomeric heterochromatin
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location in telomeric heterochromatin." [PMID:21300781]
synonym: "protein localisation to telomeric heterochromatin" EXACT [GOC:mah]
is_a: GO:0070198 ! protein localization to chromosome, telomeric region
is_a: GO:0097355 ! protein localization to heterochromatin
created_by: mah
creation_date: 2013-07-31T15:04:26Z

[Term]
id: GO:1990153
name: maintenance of protein localization to heterochromatin
namespace: biological_process
def: "A process in which a protein is maintained in a location in telomeric heterochromatin." [PMID:21300781]
synonym: "maintenance of protein localisation to heterochromatin" EXACT [GOC:mah]
synonym: "maintenance of protein location in heterochromatin" RELATED [GOC:mah]
is_a: GO:0032507 ! maintenance of protein location in cell
relationship: part_of GO:0097355 ! protein localization to heterochromatin
created_by: mah
creation_date: 2013-07-31T15:11:37Z

[Term]
id: GO:1990154
name: enzyme IIA-maltose transporter complex
namespace: cellular_component
def: "A protein complex consisting of the pentameric maltose transporter complex bound to two enzyme IIA (EIIA) molecules. EIIA is a component of the glucose-specific phosphotransferase system that inhibits maltose transport from the periplasm to the cytoplasm. When EIIA-bound, the maltose transporter remains in the open, inward-facing conformation, which prevents binding of maltose-loaded maltose binding protein (MBP) to the transporter." [GOC:bf, GOC:bhm, PMID:23770568]
synonym: "EIIA(Glc)-MalFGK2 complex" EXACT [PMID:23770568]
synonym: "EIIA(Glc)-maltose transporter complex" EXACT [PMID:23770568]
synonym: "maltose transporter inhibitor complex" RELATED [GOC:bhm]
is_a: GO:0043190 ! ATP-binding cassette (ABC) transporter complex
relationship: has_part GO:1990060 ! maltose transport complex
relationship: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0005887 ! integral component of plasma membrane
created_by: bhm
creation_date: 2013-08-01T09:27:25Z

[Term]
id: GO:1990155
name: Dsc E3 ubiquitin ligase complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a Dsc E3 ubiquitin ligase complex, an E3 ubiquitin ligase complex localized to the ER and Golgi membrane." [GOC:mah, PMID:23760507]
synonym: "Dsc complex assembly" EXACT [PMID:23760507]
is_a: GO:0043623 ! cellular protein complex assembly
created_by: mah
creation_date: 2013-08-01T14:19:19Z

[Term]
id: GO:1990156
name: DnaB-DnaG complex
namespace: cellular_component
def: "A protein complex containing homohexameric DnaB helicase, and DnaG (a primase). Facilitates the unwinding of double-stranded DNA and the synthesis of RNA primer sequences during DNA replication and repair in Prokaryotes." [GOC:bhm, PMID:14557266]
synonym: "DnaB-DnaG primosome complex" RELATED [GOC:bhm]
is_a: GO:0033202 ! DNA helicase complex
is_a: GO:0044427 ! chromosomal part
relationship: has_part GO:1990161 ! DnaB helicase complex
relationship: part_of GO:1990098 ! core primosome complex
created_by: bhm
creation_date: 2013-08-02T09:50:54Z

[Term]
id: GO:1990157
name: DnaA-DnaB-DnaC complex
namespace: cellular_component
def: "A protein-DNA complex consisting of the helicase loading complex DnaB-DnaC bound to the DNA-bound DNA replication initiation protein DnaA. Essential for DNA replication initiation." [GOC:bhm, PMID:20129058]
is_a: GO:1990099 ! pre-primosome complex
relationship: has_part GO:1990100 ! DnaB-DnaC complex
created_by: bhm
creation_date: 2013-08-02T11:42:27Z

[Term]
id: GO:1990158
name: DnaB-DnaC-DnaT-PriA-PriB complex
namespace: cellular_component
def: "A protein-DNA complex consisting of the helicase loading complex DnaB-DnaC, replication restart proteins DnaT, PriA and PriB, and associated DNA. Involved in the restart of DNA replication after a stalled replication fork has been repaired." [GOC:bhm, PMID:8663105]
synonym: "DnaB-DnaC-DnaT-PriA-PriB preprimosome" EXACT [PMID:8663105]
synonym: "phi-X174-type preprimosome" RELATED [PMID:8663105]
is_a: GO:1990099 ! pre-primosome complex
relationship: has_part GO:1990100 ! DnaB-DnaC complex
created_by: bhm
creation_date: 2013-08-02T11:52:55Z

[Term]
id: GO:1990159
name: DnaB-DnaC-DnaT-PriA-PriC complex
namespace: cellular_component
def: "A protein-DNA complex consisting of the helicase loading complex DnaB-DnaC, replication restart proteins DnaT, PriA and PriC, and associated DNA. Involved in the restart of DNA replication after a stalled replication fork has been repaired." [GOC:bhm, PMID:8663105]
synonym: "DnaB-DnaC-DnaT-PriA-PriC preprimosome" EXACT [PMID:8663105]
synonym: "phi-X174-type preprimosome" RELATED [PMID:8663105]
is_a: GO:1990099 ! pre-primosome complex
relationship: has_part GO:1990100 ! DnaB-DnaC complex
created_by: bhm
creation_date: 2013-08-02T11:58:16Z

[Term]
id: GO:1990160
name: DnaB-DnaC-Rep-PriC complex
namespace: cellular_component
def: "A protein-DNA complex consisting of the helicase loading complex DnaB-DnaC, replication restart proteins Rep and PriC, and associated DNA. Involved in the restart of DNA replication after a stalled replication fork has been repaired." [GOC:bhm, PMID:19941825, PMID:8663105]
synonym: "DnaB-DnaC-Rep-PriC preprimosome" EXACT [PMID:8663105]
synonym: "phi-X174-type preprimosome" RELATED [PMID:8663105]
is_a: GO:1990099 ! pre-primosome complex
relationship: has_part GO:1990100 ! DnaB-DnaC complex
created_by: bhm
creation_date: 2013-08-02T12:05:25Z

[Term]
id: GO:1990161
name: DnaB helicase complex
namespace: cellular_component
def: "A homohexameric protein complex that possesses DNA helicase activity; functions during DNA replication and repair." [GOC:bhm, PMID:17947583]
synonym: "DnaB hexamer" EXACT [GOC:bhm]
is_a: GO:0033202 ! DNA helicase complex
created_by: bhm
creation_date: 2013-08-02T15:55:48Z

[Term]
id: GO:1990162
name: histone deacetylase activity (H3-K4 specific)
namespace: molecular_function
def: "Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 4) + H2O = histone H3 L-lysine (position 4) + acetate. This reaction represents the removal of an acetyl group from lysine at position 4 of the histone H3 protein." [GOC:al, PMID:23771057]
is_a: GO:0004407 ! histone deacetylase activity
relationship: part_of GO:1990596 ! histone H3-K4 deacetylation
created_by: pr
creation_date: 2013-08-06T08:48:44Z

[Term]
id: GO:1990163
name: ATP-dependent four-way junction helicase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, where this reaction drives the unwinding of the DNA helix of DNA containing four-way junctions, including Holliday junctions." [GOC:al, PMID:22723423]
synonym: "ATP-dependent four-way junction DNA helicase activity" EXACT []
synonym: "ATP-dependent Holliday junction helicase activity" NARROW []
is_a: GO:0004003 ! ATP-dependent DNA helicase activity
is_a: GO:0009378 ! four-way junction helicase activity
created_by: pr
creation_date: 2013-08-07T13:36:54Z

[Term]
id: GO:1990164
name: histone H2A phosphorylation
namespace: biological_process
def: "The modification of histone H2A by the addition of a phosphate group." [GOC:mah, PMID:23080121]
is_a: GO:0016572 ! histone phosphorylation
created_by: mah
creation_date: 2013-08-08T11:13:25Z

[Term]
id: GO:1990165
name: single-strand break-containing DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with damaged DNA containing single-strand breaks (SSBs)." [GOC:al, PMID:21984210]
synonym: "single-strand break-containing damaged DNA binding" EXACT []
synonym: "SSB-containing DNA binding" EXACT []
is_a: GO:0003684 ! damaged DNA binding
created_by: pr
creation_date: 2013-08-08T11:16:04Z

[Term]
id: GO:1990166
name: protein localization to site of double-strand break
namespace: biological_process
def: "Any process in which a protein is transported to, or maintained at, a region of a chromosome at which a DNA double-strand break has occurred." [GOC:mah, PMID:23080121]
synonym: "protein localisation to site of double-strand break" EXACT [GOC:mah]
synonym: "protein localization to double-strand break site" EXACT [GOC:mah]
synonym: "protein localization to site of DSB" EXACT [GOC:mah]
is_a: GO:0034502 ! protein localization to chromosome
created_by: mah
creation_date: 2013-08-08T11:27:00Z

[Term]
id: GO:1990167
name: protein K27-linked deubiquitination
namespace: biological_process
def: "A protein deubiquitination process in which a K27-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 27 of the ubiquitin monomers, is removed from a protein." [PMID:23827681]
is_a: GO:0016579 ! protein deubiquitination
created_by: sp
creation_date: 2013-08-14T11:15:24Z

[Term]
id: GO:1990168
name: protein K33-linked deubiquitination
namespace: biological_process
def: "A protein deubiquitination process in which a K33-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 33 of the ubiquitin monomers, is removed from a protein." [PMID:23827681]
is_a: GO:0016579 ! protein deubiquitination
created_by: sp
creation_date: 2013-08-14T11:19:39Z

[Term]
id: GO:1990169
name: stress response to copper ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a copper ion stimulus." [GOC:kmv, PMID:23437011]
synonym: "response to copper ion stress" EXACT []
synonym: "response to copper toxicity" RELATED []
synonym: "stress response to copper" BROAD []
is_a: GO:0046688 ! response to copper ion
is_a: GO:0097501 ! stress response to metal ion
created_by: pr
creation_date: 2013-08-14T12:52:05Z

[Term]
id: GO:1990170
name: stress response to cadmium ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a cadmium ion stimulus." [GOC:kmv]
synonym: "response to cadmium ion stress" EXACT []
synonym: "response to cadmium toxicity" RELATED []
synonym: "stress response to cadmium" BROAD []
is_a: GO:0046686 ! response to cadmium ion
is_a: GO:0097501 ! stress response to metal ion
created_by: pr
creation_date: 2013-08-14T12:55:45Z

[Term]
id: GO:1990171
name: SCF complex disassembly in response to cadmium stress
namespace: biological_process
def: "The disaggregation of the SCF ubiquitin ligase complex in response to cadmium stress." [GOC:rb, PMID:23000173]
is_a: GO:0043241 ! protein complex disassembly
relationship: part_of GO:0071276 ! cellular response to cadmium ion
created_by: rb
creation_date: 2013-08-15T22:38:06Z

[Term]
id: GO:1990172
name: G-protein coupled receptor catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a G-protein coupled receptor." [PMID:12142540, PMID:23954414]
is_a: GO:0032801 ! receptor catabolic process
is_a: GO:0045744 ! negative regulation of G-protein coupled receptor protein signaling pathway
created_by: sp
creation_date: 2013-08-22T10:16:58Z

[Term]
id: GO:1990173
name: protein localization to nucleoplasm
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within the nucleoplasm." [GOC:mah, PMID:22918952]
synonym: "protein localisation to nucleoplasm" EXACT [GOC:mah]
is_a: GO:0034504 ! protein localization to nucleus
created_by: mah
creation_date: 2013-08-23T15:01:16Z

[Term]
id: GO:1990174
name: phosphodiesterase decapping endonuclease activity
namespace: molecular_function
def: "Catalysis of the removal of the cap from an unmethylated 5'-end capped RNA resulting in the release of the entire cap structure (GpppN) and a 5' monophosphorylated RNA." [GOC:dgf, PMID:20802481]
synonym: "G(5')pppN pyrophosphatase activity" RELATED []
is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters
created_by: tb
creation_date: 2013-08-26T17:51:00Z

[Term]
id: GO:1990175
name: EH domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an EH domain of a protein. The EH stand for Eps15 homology. This was originally identified as a motif present in three copies at the NH2-termini of Eps15 and of the related molecule Eps15R." [GOC:hjd, PMID:11911876, PMID:21115825]
is_a: GO:0019904 ! protein domain specific binding
created_by: hjd
creation_date: 2013-08-27T20:14:56Z

[Term]
id: GO:1990176
name: MalFGK2 complex
namespace: cellular_component
def: "Protein complex involved in maltose transport through the plasma membrane. In E. coli, the complex is a tetramer and consists of a cytoplasmic ATPase MalK homodimer together with a heterodimeric transmembrane subunit MalF-MalG." [GOC:bhm, PMID:19250913]
comment: The MalFGK2 complex lacks the maltose-binding subunit present in GO:1990060.
synonym: "MalF-MalG-MalK(2) complex" EXACT [GOC:bf]
synonym: "MalF-MalG-MalK-MalK complex" EXACT [GOC:bf]
synonym: "MalFGK(2) complex" EXACT [PMID:19250913]
synonym: "maltose transport complex, core subunit" EXACT [GOC:bhm]
synonym: "maltose transport MalFGK2 complex" EXACT [GOC:bhm]
is_a: GO:0098797 ! plasma membrane protein complex
relationship: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:1990060 ! maltose transport complex
created_by: bhm
creation_date: 2013-08-30T11:10:14Z

[Term]
id: GO:1990177
name: IHF-DNA complex
namespace: cellular_component
def: "A protein-DNA complex containing IHF heterodimers (an alpha and a beta chain) bound to DNA. IHF binds to double-stranded DNA in a structure- and sequence-specific manner and bends the DNA into a nucleosome-like structure, the bacterial nucleoid." [GOC:bhm, PMID:17097674]
synonym: "IHF complex" EXACT [GOC:bhm]
synonym: "IHFa-IHFb-DNA complex" EXACT [GOC:bhm]
is_a: GO:0032993 ! protein-DNA complex
is_a: GO:0044422 ! organelle part
is_a: GO:0044424 ! intracellular part
is_a: GO:1990104 ! DNA bending complex
relationship: part_of GO:0043590 ! bacterial nucleoid
created_by: bhm
creation_date: 2013-08-30T12:22:54Z

[Term]
id: GO:1990178
name: HU-DNA complex
namespace: cellular_component
def: "A protein-DNA complex that consists of HU heterodimers (an alpha and a beta chain) assembled into octamers along DNA. HU binds to double-stranded DNA in a structure- and sequence-specific manner and bends the DNA into a nucleosome-like structure." [GOC:bhm, PMID:17360520]
synonym: "HU complex" BROAD [GOC:bhm]
is_a: GO:0032993 ! protein-DNA complex
is_a: GO:0044422 ! organelle part
is_a: GO:0044424 ! intracellular part
is_a: GO:1990104 ! DNA bending complex
relationship: part_of GO:0043590 ! bacterial nucleoid
created_by: bhm
creation_date: 2013-08-30T13:06:53Z

[Term]
id: GO:1990179
name: protein localization to actomyosin contractile ring
namespace: biological_process
def: "A process in which a protein is transported to, or maintained at, the actomyosin contractile ring." [GOC:mah, PMID:23349808]
synonym: "protein localisation to actomyosin contractile ring" EXACT []
is_a: GO:0072697 ! protein localization to cell cortex
is_a: GO:0072741 ! protein localization to cell division site
is_a: GO:1903119 ! protein localization to actin cytoskeleton
created_by: mah
creation_date: 2013-08-30T16:13:54Z

[Term]
id: GO:1990180
name: mitochondrial tRNA 3'-end processing
namespace: biological_process
def: "The process in which the 3' end of a pre-tRNA molecule is converted to that of a mature tRNA in the mitochondrion." [GOC:mah, GOC:TermGenie, PMID:23928301]
synonym: "tRNA 3' processing in mitochondria" EXACT [GOC:TermGenie]
synonym: "tRNA 3' processing in mitochondrion" EXACT [GOC:TermGenie]
synonym: "tRNA 3'-end processing in mitochondria" EXACT [GOC:TermGenie]
is_a: GO:0000965 ! mitochondrial RNA 3'-end processing
is_a: GO:0042780 ! tRNA 3'-end processing
is_a: GO:0090646 ! mitochondrial tRNA processing
intersection_of: GO:0042780 ! tRNA 3'-end processing
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion
created_by: mah
creation_date: 2013-08-30T16:17:36Z

[Term]
id: GO:1990181
name: acetyl-CoA biosynthetic process from pantothenate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of acetyl-CoA from pantothenate via phosphopantothenate and CoA." [GOC:mah, PMID:23091701]
synonym: "acetyl-CoA anabolism from pantothenate" EXACT []
synonym: "acetyl-CoA formation from pantothenate" RELATED []
synonym: "acetyl-CoA synthesis from pantothenate" RELATED []
is_a: GO:0006085 ! acetyl-CoA biosynthetic process
is_a: GO:0015939 ! pantothenate metabolic process
is_a: GO:0044711 ! single-organism biosynthetic process
created_by: mah
creation_date: 2013-08-30T16:20:44Z

[Term]
id: GO:1990182
name: exosomal secretion
namespace: biological_process
def: "The process whereby a membrane-bounded vesicle are released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane." [GOC:hjd, PMID:18617898]
synonym: "exosomal protein secretion" NARROW [PMID:18617898]
synonym: "exosomal secretory pathway" EXACT [PMID:18617898]
synonym: "extracellular vesicular exosome secretion" EXACT [GOC:hjd]
synonym: "secretion of exosome" EXACT [PMID:18617898]
is_a: GO:0006887 ! exocytosis
created_by: hjd
creation_date: 2013-09-04T21:08:14Z

[Term]
id: GO:1990183
name: lymphatic vascular process in circulatory system
namespace: biological_process
def: "A circulatory process that occurs at the level of the lymphatic vasculature." [PMID:21576390]
is_a: GO:0003018 ! vascular process in circulatory system
created_by: sl
creation_date: 2013-09-10T22:26:40Z

[Term]
id: GO:1990184
name: amino acid transport complex
namespace: cellular_component
def: "A heteromeric protein complex consisting of a multi-transmembrane spanning subunit (the light chain) and a type II glycoprotein subunit (the heavy chain) that functions to transport amino acids across a plasma membrane." [GOC:kmv, PMID:14668347]
is_a: GO:0098797 ! plasma membrane protein complex
created_by: jl
creation_date: 2013-09-11T15:02:16Z

[Term]
id: GO:1990185
name: regulation of lymphatic vascular permeability
namespace: biological_process
def: "Any process that modulates the extent to which lymphatic vessels can be pervaded by fluid." [PMID:23897233]
is_a: GO:0043114 ! regulation of vascular permeability
is_a: GO:1990183 ! lymphatic vascular process in circulatory system
created_by: sl
creation_date: 2013-09-11T15:36:22Z

[Term]
id: GO:1990186
name: regulation of lymphatic vessel size
namespace: biological_process
def: "Any process that modulates the size of lymphatic vessels." [PMID:23897233]
synonym: "regulation of collecting lymphatic vessel size" NARROW []
is_a: GO:0090066 ! regulation of anatomical structure size
is_a: GO:1990183 ! lymphatic vascular process in circulatory system
created_by: sl
creation_date: 2013-09-11T15:41:16Z

[Term]
id: GO:1990187
name: obsolete protein localization to mRNA
namespace: biological_process
def: "OBSOLETE. A process in which a protein is transported to, or maintained at mRNA." [GOC:rb, PMID:22890846]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
subset: termgenie_unvetted
synonym: "protein localization to mRNA" EXACT []
is_obsolete: true
created_by: rb
creation_date: 2013-09-11T18:19:20Z

[Term]
id: GO:1990188
name: euchromatin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with euchromatin, a dispersed and relatively uncompacted form of chromatin." [GOC:vw, PMID:22431512]
is_a: GO:0003682 ! chromatin binding
created_by: tb
creation_date: 2013-09-11T19:18:38Z

[Term]
id: GO:1990189
name: peptide-serine-N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + N-terminal L-serine in peptide = CoA + N-acetyl-L-serine-peptide." [GOC:al, PMID:23912279]
is_a: GO:0004596 ! peptide alpha-N-acetyltransferase activity
created_by: tb
creation_date: 2013-09-11T20:13:40Z

[Term]
id: GO:1990190
name: peptide-glutamate-N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + N-terminal L-glutamate in peptide = CoA + N-acetyl-L-glutamate-peptide." [GOC:al, PMID:23912279]
is_a: GO:0004596 ! peptide alpha-N-acetyltransferase activity
created_by: tb
creation_date: 2013-09-11T20:21:25Z

[Term]
id: GO:1990191
name: cobalamin transport complex
namespace: cellular_component
def: "Protein complex facilitating ATP-dependent cobalamin (vitamin B12) transport through inner cell membrane (periplasm to cytoplasm) in Gram-negative bacteria. In E. coli the system is composed of a periplasmic cobalamin-binding protein (BtuF), an integral membrane homodimer, BtuC, and a cytoplasmic ATP-binding homodimer BtuD." [GOC:bhm, PMID:22569249]
synonym: "BtuCDF complex" EXACT []
synonym: "cobalamin-transporting BtuCDF complex" EXACT []
synonym: "vitamin B12 transport complex" EXACT []
synonym: "vitamin B12-transporting BtuCDF complex" EXACT []
is_a: GO:0043190 ! ATP-binding cassette (ABC) transporter complex
relationship: has_part GO:1990193 ! BtuCD complex
relationship: part_of GO:0005886 ! plasma membrane
created_by: bhm
creation_date: 2013-09-12T14:20:19Z

[Term]
id: GO:1990192
name: collecting lymphatic vessel constriction
namespace: biological_process
def: "A decrease in the diameter of collecting lymphatic vessels." [PMID:23322290]
synonym: "lymphatic vessel myogenic constriction" EXACT []
is_a: GO:1990186 ! regulation of lymphatic vessel size
created_by: sl
creation_date: 2013-09-12T14:46:05Z

[Term]
id: GO:1990193
name: BtuCD complex
namespace: cellular_component
def: "Protein complex involved in cobalamin (vitamin B12) transport through the plasma membrane. In E. coli, the complex is a tetramer and consists of the cytoplasmic ATPase BtuD homodimer together with the transmembrane BtuC homodimer." [GOC:bhm, PMID:22569249]
synonym: "BtuC-BtuD complex" EXACT []
synonym: "cobalamin transport complex, core subunit" EXACT []
synonym: "vitamin B12 transport complex, core subunit" EXACT []
is_a: GO:0043190 ! ATP-binding cassette (ABC) transporter complex
relationship: part_of GO:0005886 ! plasma membrane
created_by: bhm
creation_date: 2013-09-12T14:58:56Z

[Term]
id: GO:1990194
name: cytoplasmic U snRNP body assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic U snRNP body." [PMID:19464282]
synonym: "U body assembly" RELATED []
is_a: GO:0022618 ! ribonucleoprotein complex assembly
created_by: tb
creation_date: 2013-09-12T21:54:20Z

[Term]
id: GO:1990195
name: macrolide transmembrane transporter complex
namespace: cellular_component
def: "A bacterial transmembrane transporter complex that spans the entire cell membrane system and possesses ATP-dependent xenobiotic transport activity pumping drugs (typically antibiotics) and other toxins directly from the cytosol out of the bacterial cell. Typically, it is trimeric consisting of a inner membrane ATPase (IMP), a periplasmic membrane fusion protein (MFP) and an outer membrane factor (OMF). In E. coli, macrolide transporter complexes may consists of MacB (IMP), MacA (MFP) and TolC (OMF) or AcrB (IMP), AcrA (MFP) and TolC (OMF). Trimeric TolC is a common OMF found in many macrolide transporter complexes." [GOC:bhm, PMID:10879525, PMID:18955484, PMID:19254725]
synonym: "AcrAB-TolC complex" NARROW []
synonym: "MacAB-TolC complex" NARROW []
synonym: "macrolide transporter" RELATED []
synonym: "macrolide transporter complex" BROAD []
is_a: GO:1902495 ! transmembrane transporter complex
relationship: part_of GO:0016020 ! membrane
created_by: bhm
creation_date: 2013-09-23T11:22:26Z

[Term]
id: GO:1990196
name: MacAB-TolC complex
namespace: cellular_component
def: "The MacAB-TolC complex is a macrolide transporter complex found in E.coli and related gram-negative bacteria. Its transport activity is specific to macrolide compounds containing 14- and 15-membered lactones. It consists of the dimeric inner membrane ATPase MacB, the hexameric, periplasmic membrane fusion protein MacA and the trimeric outer membrane factor TolC." [GOC:bhm, PMID:10879525, PMID:18955484, PMID:19254725]
synonym: "macrolide transporter MacAB-TolC complex" EXACT []
is_a: GO:1990195 ! macrolide transmembrane transporter complex
relationship: part_of GO:0016020 ! membrane
created_by: bhm
creation_date: 2013-09-23T11:29:28Z

[Term]
id: GO:1990197
name: ATP-dependent methionine-importing complex
namespace: cellular_component
def: "An ATP-binding cassette (ABC) transporter complex that is capable of methionine-importing activity. An example is the bacterial MetNIQ methionine transporter, that consists of the dimeric ATPase subunit MetN located at the cytoplasmic side of the plasma membrane and the dimeric transmembrane subunit MetI. MetQ is regarded as the periplasmic methionine-binding chaperon subunit, and is capable of transporting methionine from the periplasm into the cytoplasm in an ATP-dependent manner." [GOC:bhm, PMID:22095702]
synonym: "ATP-binding cassette (ABC) methionine importer complex" EXACT []
synonym: "ATP-dependent methionine importer complex" EXACT []
synonym: "ATP-dependent methionine importing complex" EXACT []
synonym: "methionine transport complex" BROAD []
synonym: "methionine transporter" RELATED []
synonym: "methionine transporter complex" BROAD []
synonym: "methionine transporter complex, ATP-dependent" BROAD []
synonym: "MetNI complex" NARROW []
synonym: "MetNI transport complex" NARROW []
synonym: "MetNI transporter" RELATED []
synonym: "MetNI transporter complex" NARROW []
synonym: "MetNIQ complex" NARROW []
synonym: "MetNIQ transport complex" NARROW []
synonym: "MetNIQ transporter" RELATED []
synonym: "MetNIQ transporter complex" RELATED []
is_a: GO:0043190 ! ATP-binding cassette (ABC) transporter complex
is_a: GO:1902509 ! methionine-importing complex
created_by: bhm
creation_date: 2013-09-26T09:38:26Z

[Term]
id: GO:1990198
name: ModE complex
namespace: cellular_component
def: "A dimeric protein complex containing two ModE subunits. Binds directly to DNA to regulate transcription, and is involved in (positively and negatively) regulating various aspects of molybdenum metabolism." [GOC:bhm, PMID:12581638]
synonym: "ModE dimer" EXACT [GOC:bhm]
is_a: GO:0044445 ! cytosolic part
is_a: GO:0044797 ! cytoplasmic transcription factor complex
relationship: part_of GO:0005829 ! cytosol
created_by: bhm
creation_date: 2013-10-01T07:28:52Z

[Term]
id: GO:1990199
name: MsbA transporter complex
namespace: cellular_component
def: "An ATP-binding cassette (ABC) transporter complex made up of a dimer of MsbA. Facilitates the export across the plasma membrane of, amongst others, lipid A and lipopolysaccharide. In contrast to most ABC transporter complexes, each chain of the homodimer contains both the transmembrane domain (TMD) and the cytoplasmic ATP-binding domain (NBD)." [GOC:bhm, PMID:18024585]
synonym: "MsbA complex" EXACT [GOC:bhm]
synonym: "MsbA dimer" EXACT [GOC:bhm]
is_a: GO:0043190 ! ATP-binding cassette (ABC) transporter complex
relationship: part_of GO:0005886 ! plasma membrane
created_by: bhm
creation_date: 2013-10-01T07:49:41Z

[Term]
id: GO:1990200
name: SsuD-SsuE complex
namespace: cellular_component
def: "A protein complex containing an alkanesulfonate monooxygenase subunit (SsuD tetramer in E.coli) and a flavin oxidoreductase subunit (SsuE dimer in E.coli). Involved in the utilization of alkanesulfonates as sulfur sources under conditions of sulfate or cysteine starvation." [GOC:bhm, PMID:16997955]
synonym: "two-component alkanesulfonate monooxygenase system" RELATED [GOC:bhm]
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part
relationship: has_part GO:1990201 ! alkanesulfonate monooxygenase complex
relationship: has_part GO:1990202 ! FMN reductase complex
relationship: part_of GO:0005829 ! cytosol
created_by: bhm
creation_date: 2013-10-03T12:59:26Z

[Term]
id: GO:1990201
name: alkanesulfonate monooxygenase complex
namespace: cellular_component
def: "A protein complex capable of alkanesulfonate monooxygenase activity. Involved in the utilization of alkanesulfonates as sulfur sources under conditions of sulfate or cysteine starvation, catalyzing the conversion of alkanesulfonates into aldehydes and sulfite. In E.coli the complex consists of a SsuD tetramer." [GOC:bhm, PMID:10480865, PMID:16997955]
synonym: "SsuD complex" NARROW [GOC:bhm]
is_a: GO:0044445 ! cytosolic part
is_a: GO:1990204 ! oxidoreductase complex
relationship: part_of GO:0005829 ! cytosol
created_by: bhm
creation_date: 2013-10-03T14:55:08Z

[Term]
id: GO:1990202
name: FMN reductase complex
namespace: cellular_component
def: "A protein complex capable of FMN reductase activity. Reduces FMN to FMNH2 in a NAD(P)H-dependent manner. In E.coli, consists of a SsuE dimer." [GOC:bhm, PMID:10480865, PMID:16997955]
synonym: "flavin oxidoreductase complex, NAD(P)H-dependent" BROAD [GOC:bhm]
synonym: "FMN oxidoreductase complex, NAD(P)H-dependent" RELATED [GOC:bhm]
synonym: "FMN reductase complex, NAD(P)H-dependent" EXACT [GOC:bhm]
synonym: "SsuE complex" NARROW [GOC:bhm]
is_a: GO:0044445 ! cytosolic part
is_a: GO:1990204 ! oxidoreductase complex
relationship: part_of GO:0005829 ! cytosol
created_by: bhm
creation_date: 2013-10-03T15:07:20Z

[Term]
id: GO:1990203
name: MdtBC Complex
namespace: cellular_component
def: "A protein complex containing two transmembrane subunits; a MdtB dimer and one unit of MdtC. Capable of exporting substrates across the cell membrane. Involved in conferring antibiotic resistance of Gram-negative bacteria by transporting drugs across the membrane." [GOC:bhm, PMID:20038594]
synonym: "multidrug efflux pump MdtBC" EXACT [GOC:bhm]
is_a: GO:0098797 ! plasma membrane protein complex
is_a: GO:1902495 ! transmembrane transporter complex
relationship: part_of GO:0005886 ! plasma membrane
created_by: bhm
creation_date: 2013-10-04T21:22:18Z

[Term]
id: GO:1990204
name: oxidoreductase complex
namespace: cellular_component
def: "Any protein complex that possesses oxidoreductase activity." [GOC:bhm, PMID:18982432]
synonym: "oxidation-reduction complex" EXACT []
synonym: "redox complex" EXACT []
is_a: GO:0044464 ! cell part
is_a: GO:1902494 ! catalytic complex
relationship: part_of GO:0005623 ! cell
created_by: bhm
creation_date: 2013-10-07T08:24:47Z

[Term]
id: GO:1990205
name: taurine dioxygenase complex
namespace: cellular_component
def: "A protein complex capable of catalyzing the conversion of taurine and alpha-ketoglutarate to sulfite, aminoacetaldehyde and succinate under sulfur or cysteine starvation conditions. Its expression is repressed by the presence of sulfate or cysteine. In E. coli it is a homodimer or homotetramer of the protein TauD." [GOC:bhm, PMID:12741810]
synonym: "2-aminoethanesulfonate dioxygenase complex" EXACT []
synonym: "alpha-ketoglutarate-dependent taurine dioxygenase complex" EXACT []
synonym: "TauD complex" NARROW []
is_a: GO:0044445 ! cytosolic part
is_a: GO:1990204 ! oxidoreductase complex
relationship: part_of GO:0005829 ! cytosol
created_by: bhm
creation_date: 2013-10-07T13:03:15Z

[Term]
id: GO:1990206
name: jasmonyl-Ile conjugate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: jasmonyl-Ile + H2O = jasmonic acid + L-isoleucine." [PMID:23943861]
synonym: "JA-Ile hydrolase" RELATED []
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
created_by: tb
creation_date: 2013-10-07T18:37:49Z

[Term]
id: GO:1990207
name: EmrE multidrug transporter complex
namespace: cellular_component
def: "A transmembrane protein complex capable of transporting positively charged hydrophobic drugs across the plasma membrane thereby involved in conferring resistance to a wide range of toxic compounds (e.g. methyl viologen, ethidium bromide and acriflavine). It is commonly found in bacteria. In E. coli it forms a homodimer." [GOC:bhm, PMID:18024586]
synonym: "EmrE complex" NARROW []
is_a: GO:0098797 ! plasma membrane protein complex
is_a: GO:1902495 ! transmembrane transporter complex
relationship: part_of GO:0005887 ! integral component of plasma membrane
created_by: bhm
creation_date: 2013-10-08T08:37:52Z

[Term]
id: GO:1990208
name: positive regulation by symbiont of RNA levels in host
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the RNA levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:12182338, PMID:18703740]
is_a: GO:0052018 ! modulation by symbiont of RNA levels in host
created_by: ml
creation_date: 2013-10-08T13:31:41Z

[Term]
id: GO:1990209
name: negative regulation by symbiont of RNA levels in host
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the RNA levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:ml, PMID:18703740]
is_a: GO:0052018 ! modulation by symbiont of RNA levels in host
created_by: ml
creation_date: 2013-10-09T18:09:33Z

[Term]
id: GO:1990210
name: positive regulation by symbiont of indole acetic acid levels in host
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the indole acetic acid levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:ml, PMID:18056646]
synonym: "positive regulation by symbiont of auxin levels in host" EXACT []
synonym: "positive regulation by symbiont of IAA levels in host" EXACT []
is_a: GO:0044032 ! modulation by symbiont of indole acetic acid levels in host
is_a: GO:0052024 ! positive regulation by symbiont of hormone or growth regulator levels in host
created_by: ml
creation_date: 2013-10-09T18:54:11Z

[Term]
id: GO:1990211
name: positive regulation by symbiont of jasmonic acid levels in host
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the jasmonic acid levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:ml, PMID:14617079, PMID:16553894]
is_a: GO:0052022 ! modulation by symbiont of jasmonic acid levels in host
is_a: GO:0052024 ! positive regulation by symbiont of hormone or growth regulator levels in host
created_by: ml
creation_date: 2013-10-09T18:58:37Z

[Term]
id: GO:1990212
name: positive regulation by symbiont of ethylene levels in host
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the ethylene levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:ml, PMID:16167902]
is_a: GO:0052021 ! modulation by symbiont of ethylene levels in host
is_a: GO:0052024 ! positive regulation by symbiont of hormone or growth regulator levels in host
created_by: ml
creation_date: 2013-10-09T19:03:10Z

[Term]
id: GO:1990213
name: negative regulation by symbiont of salicylic acid levels in host
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of salicylic acid levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:ml, PMID:17722699, PMID:20565685]
is_a: GO:0052023 ! modulation by symbiont of salicylic acid levels in host
is_a: GO:0052024 ! positive regulation by symbiont of hormone or growth regulator levels in host
created_by: ml
creation_date: 2013-10-09T19:06:19Z

[Term]
id: GO:1990214
name: negative regulation by symbiont of host protein levels
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of protein levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:16840699, PMID:22233353]
is_a: GO:0075344 ! modulation by symbiont of host protein levels
created_by: ml
creation_date: 2013-10-10T15:39:45Z

[Term]
id: GO:1990215
name: negative regulation by symbiont of host intracellular transport
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of intracellular transport in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:22319451]
is_a: GO:0032387 ! negative regulation of intracellular transport
is_a: GO:0052038 ! modulation by symbiont of host intracellular transport
intersection_of: GO:0044068 ! modulation by symbiont of host cellular process
intersection_of: negatively_regulates GO:0046907 ! intracellular transport
relationship: negatively_regulates GO:0046907 ! intracellular transport
created_by: ml
creation_date: 2013-10-10T15:42:22Z

[Term]
id: GO:1990216
name: positive regulation by symbiont of host transcription
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of transcription in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:21994350]
is_a: GO:0052026 ! modulation by symbiont of host transcription
created_by: ml
creation_date: 2013-10-10T15:45:17Z

[Term]
id: GO:1990217
name: negative regulation by symbiont of host phytoalexin production
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of phytoalexin production in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:21402357]
is_a: GO:0052165 ! modulation by symbiont of host phytoalexin production
created_by: ml
creation_date: 2013-10-10T15:49:33Z

[Term]
id: GO:1990218
name: positive regulation by symbiont of abscisic acid levels in host
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the abscisic acid levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:17304219]
is_a: GO:0075343 ! modulation by symbiont of abscisic acid levels in host
created_by: ml
creation_date: 2013-10-10T15:54:10Z

[Term]
id: GO:1990219
name: positive regulation by symbiont of host protein levels
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of protein levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:20615948]
is_a: GO:0075344 ! modulation by symbiont of host protein levels
created_by: ml
creation_date: 2013-10-10T17:26:03Z

[Term]
id: GO:1990220
name: GroEL-GroES complex
namespace: cellular_component
def: "Bacterial chaperonin complex consisting of a heptameric 10kDa chaperonin subunit GroES and a tetradecameric (2x7) 60kDa chaperonin subunit GroEL. The 60kDa subunit possesses ATPase activity while the holo-enzyme is responsible for the correct folding of proteins." [GOC:bhm, PMID:15313620]
synonym: "bacterial chaperonin ATPase complex" RELATED []
synonym: "bacterial chaperonin complex" RELATED []
is_a: GO:0016465 ! chaperonin ATPase complex
relationship: part_of GO:0005829 ! cytosol
created_by: bhm
creation_date: 2013-10-11T09:20:01Z

[Term]
id: GO:1990221
name: L-cysteine desulfurase complex
namespace: cellular_component
def: "A protein complex capable of cysteine desulfurase activity decomposing L-cysteine to L-alanine and sulfur. It belongs to a ubiquitous family of pyridoxal 5-phosphate (PLP)-dependent enzymes. In E. coli it consists of a SufS dimer." [GOC:bhm, PMID:11827487]
synonym: "IscS" NARROW [GOC:bhm, GOC:dph]
synonym: "NIFS" NARROW [GOC:bhm, GOC:dph]
synonym: "NifS" NARROW [GOC:bhm, GOC:dph]
synonym: "SufS complex" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part
relationship: part_of GO:0005829 ! cytosol
created_by: bhm
creation_date: 2013-10-11T15:36:34Z

[Term]
id: GO:1990222
name: ProVWX complex
namespace: cellular_component
def: "The ProVWX complex belongs to the family of ATP-binding cassette (ABC) transporter proteins complexes. It consists of a cytoplasmic ATPase subunit ProV, a transmembrane subunit ProW and a periplasmic binding protein ProX. It is capable of translocating a wide variety of solute (e.g. glycine betaine) across the plasma membrane and is activated under osmotic stress conditions." [GOC:bhm, PMID:23249124]
synonym: "ATP-binding cassette (ABC) transporter complex ProVWX" EXACT []
is_a: GO:0043190 ! ATP-binding cassette (ABC) transporter complex
relationship: part_of GO:0005886 ! plasma membrane
created_by: bhm
creation_date: 2013-10-16T09:09:17Z

[Term]
id: GO:1990223
name: positive regulation by symbiont of cytokinin levels in host
namespace: biological_process
def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the cytokinin levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:24124900]
is_a: GO:0052024 ! positive regulation by symbiont of hormone or growth regulator levels in host
created_by: ml
creation_date: 2013-10-16T15:27:27Z

[Term]
id: GO:1990224
name: NMN phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-nicotinamide D-ribonucleotide (NMN-) + H2O = beta-nicotinamide D-riboside (nicotinamide ribose, NmR) + phosphate." [GOC:rb, PMID:21349851, RHEA:30818]
synonym: "beta-nicotinamide D-ribonucleotide phosphatase activity" EXACT []
synonym: "nicotinamide mononucleotide phosphatase activity" EXACT []
is_a: GO:0016791 ! phosphatase activity
created_by: rb
creation_date: 2013-10-21T18:03:41Z

[Term]
id: GO:1990225
name: rhoptry neck
namespace: cellular_component
def: "Narrow, electron-dense part of the rhoptry that extends through the conoid at the apical tip of an apicomplexan parasite. The rhoptry neck serves as a duct through which the contents of the rhoptry are secreted after attachment to the host has been completed and at the commencement of invasion." [GOC:giardia, GOC:pr, PMID:23499754, PMID:23937520, PMID:24002067, PMID:24070999]
is_a: GO:0044464 ! cell part
relationship: part_of GO:0020008 ! rhoptry
created_by: pr
creation_date: 2013-11-03T14:19:26Z

[Term]
id: GO:1990226
name: histone methyltransferase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a histone methyltransferase enzyme." [GOC:ame, GOC:BHF, PMID:19486527]
is_a: GO:0019899 ! enzyme binding
created_by: pr
creation_date: 2013-11-07T11:59:58Z

[Term]
id: GO:1990227
name: paranodal junction maintenance
namespace: biological_process
def: "The maintenance of a paranodal junction, a highly specialized cell-cell junction found in vertebrates, which forms between a neuron and a glial cell, and has structural similarity to Drosophila septate junctions. A paranodal junction flanks the node of Ranvier in myelinated nerve, electrically isolates the myelinated from unmyelinated nerve segments, and physically separates the voltage-gated sodium channels at the node from the cluster of potassium channels underneath the myelin sheath." [GOC:pr, PMID:24011083]
synonym: "axoglial septate junction maintenance" EXACT []
synonym: "paranodal axoglial junction maintenance" EXACT []
synonym: "paranodal septate maintenance" EXACT []
is_a: GO:0045217 ! cell-cell junction maintenance
created_by: pr
creation_date: 2013-11-07T20:01:46Z

[Term]
id: GO:1990228
name: sulfurtransferase complex
namespace: cellular_component
def: "A protein complex capable of catalyzing the transfer of sulfur atoms from one compound (donor) to another (acceptor)." [GOC:bhm, PMID:17350958]
synonym: "SufE complex" NARROW [GOC:bhm]
synonym: "SufE dimer" NARROW [GOC:bhm]
synonym: "sulfur transfer complex" EXACT [GOC:bhm]
synonym: "ThiF-ThiS complex" RELATED [GOC:bhm]
is_a: GO:0044445 ! cytosolic part
is_a: GO:1990234 ! transferase complex
relationship: part_of GO:0005829 ! cytosol
created_by: bhm
creation_date: 2013-11-12T09:08:23Z

[Term]
id: GO:1990229
name: iron-sulfur cluster assembly complex
namespace: cellular_component
def: "A protein complex capable of assembling an iron-sulfur (Fe-S) cluster." [GOC:bhm, PMID:17350958]
synonym: "Fe-S cluster assembly complex" NARROW [GOC:bhm]
synonym: "SufBCD complex" NARROW [GOC:bhm]
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part
relationship: part_of GO:0005829 ! cytosol
created_by: bhm
creation_date: 2013-11-12T09:15:03Z

[Term]
id: GO:1990230
name: iron-sulfur cluster transfer complex
namespace: cellular_component
def: "A protein complex capable of catalyzing the transfer of an iron-sulfur (Fe-S) cluster from one compound (donor) to another (acceptor)." [GOC:bhm, PMID:19810706]
synonym: "Fe-S cluster transfer complex" EXACT [GOC:bhm]
synonym: "IscA complex" NARROW [GOC:bhm]
synonym: "SufA complex" NARROW [GOC:bhm]
synonym: "SufA dimer" NARROW [GOC:bhm]
is_a: GO:0044445 ! cytosolic part
is_a: GO:1990234 ! transferase complex
relationship: part_of GO:0005829 ! cytosol
created_by: bhm
creation_date: 2013-11-12T09:17:40Z

[Term]
id: GO:1990231
name: STING complex
namespace: cellular_component
def: "A protein dimer containing two STING monomers. It binds cyclic purine di-nucleotides.  Activation of the sting complex by 2',5'-3'-5'-cyclic GMP-AMP activates nuclear transcription factor kB (NF-kB) and interferon regulatory factor 3 (IRF3) which then induce transcription of the genes encoding type I IFN and cytokines active in the  innate immune response." [GOC:bhm, PMID:22705373, PMID:23706668, PMID:23910378]
synonym: "stimulator of interferon genes complex" EXACT [GOC:bhm, PMID:22705373, PMID:23910378]
is_a: GO:0044433 ! cytoplasmic vesicle part
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0030659 ! cytoplasmic vesicle membrane
created_by: bhm
creation_date: 2013-11-12T10:58:34Z

[Term]
id: GO:1990232
name: phosphomannomutase complex
namespace: cellular_component
def: "A protein complex capable of phosphomannomutase activity." [GOC:bhm, PMID:16540464]
synonym: "PMM-1 complex" NARROW [GOC:bhm]
synonym: "PMM-1 dimer" NARROW [GOC:bhm]
synonym: "PMM-2 complex" NARROW [GOC:bhm]
synonym: "PMM-2 dimer" NARROW [GOC:bhm]
is_a: GO:1990233 ! intramolecular phosphotransferase complex
relationship: part_of GO:0005829 ! cytosol
created_by: bhm
creation_date: 2013-11-12T13:05:54Z

[Term]
id: GO:1990233
name: intramolecular phosphotransferase complex
namespace: cellular_component
def: "A protein complex capable of catalyzing the transfer of a phosphate group from one position to another within a single molecule." [GOC:bhm, PMID:16540464]
is_a: GO:0044445 ! cytosolic part
is_a: GO:1902494 ! catalytic complex
relationship: part_of GO:0005829 ! cytosol
created_by: bhm
creation_date: 2013-11-12T13:10:12Z

[Term]
id: GO:1990234
name: transferase complex
namespace: cellular_component
def: "A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464]
is_a: GO:1902494 ! catalytic complex
created_by: bhm
creation_date: 2013-11-12T13:20:12Z

[Term]
id: GO:1990235
name: diamine N-acetyltransferase complex
namespace: cellular_component
def: "A protein complex which is capable of diamine N-acetyltransferase activity." [GOC:bhm, PMID:8077207]
synonym: "SAT complex" NARROW [GOC:bhm]
synonym: "SAT tetramer" NARROW [GOC:bhm]
synonym: "spermidine acetyltransferase complex" NARROW [GOC:bhm]
is_a: GO:0044445 ! cytosolic part
is_a: GO:1902493 ! acetyltransferase complex
relationship: part_of GO:0005829 ! cytosol
created_by: bhm
creation_date: 2013-11-13T16:29:45Z

[Term]
id: GO:1990236
name: proteasome core complex import into nucleus
namespace: biological_process
def: "The directed movement of the proteasome core complex (AKA core particle (CP)) from the cytoplasm into the nucleus." [GOC:dos, GOC:rb, PMID:23982732]
is_a: GO:0006606 ! protein import into nucleus
is_a: GO:0015833 ! peptide transport
is_a: GO:0031503 ! protein complex localization
created_by: rb
creation_date: 2013-11-14T23:27:24Z

[Term]
id: GO:1990237
name: sequestration of proteasome core complex in proteasome storage granule
namespace: biological_process
def: "Any process where the proteasome core particle (CP) is sequestered in the protein storage granule in the cytoplasm." [GOC:rb, PMID:23982732]
is_a: GO:0098545 ! maintenance of protein complex location in cytoplasm
relationship: occurs_in GO:0034515 ! proteasome storage granule
created_by: rb
creation_date: 2013-11-14T23:29:41Z

[Term]
id: GO:1990238
name: double-stranded DNA endodeoxyribonuclease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within a double-stranded deoxyribonucleic acid molecule by creating internal breaks." [GOC:PG, PMID:22885404]
synonym: "dsDNA-specific endodeoxyribonuclease activity" RELATED []
is_a: GO:0004520 ! endodeoxyribonuclease activity
created_by: pg
creation_date: 2013-11-15T00:59:42Z

[Term]
id: GO:1990239
name: steroid hormone binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a steroid hormone." [GOC:ln]
is_a: GO:0005496 ! steroid binding
is_a: GO:0042562 ! hormone binding
created_by: pr
creation_date: 2013-11-15T09:26:18Z

[Term]
id: GO:1990240
name: methionine-importing activity
namespace: molecular_function
def: "Catalysis of the transfer of methionine into a cell or organelle, across a membrane." [GOC:pr]
synonym: "methionine importer" RELATED []
synonym: "methionine importer activity" EXACT []
synonym: "methionine importing activity" EXACT []
is_a: GO:0043865 ! methionine transmembrane transporter activity
relationship: part_of GO:0044690 ! methionine import
created_by: pr
creation_date: 2013-11-15T10:35:04Z

[Term]
id: GO:1990241
name: obsolete nucleotide binding complex
namespace: cellular_component
def: "OBSOLETE. A protein complex that interacts selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. An example of this is STING in E. coli (Q86WV6)." [GOC:bhm, PMID:23910378]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
subset: termgenie_unvetted
synonym: "nucleotide binding complex" EXACT []
is_obsolete: true
created_by: bhm
creation_date: 2013-11-22T16:22:07Z

[Term]
id: GO:1990242
name: obsolete innate immune response complex
namespace: cellular_component
def: "OBSOLETE. A protein complex involved in the innate immune response." [GOC:bhm, PMID:23910378]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
subset: termgenie_unvetted
synonym: "innate immune response complex" EXACT []
is_obsolete: true
created_by: bhm
creation_date: 2013-11-26T13:36:52Z

[Term]
id: GO:1990243
name: atf1-pcr1 complex
namespace: cellular_component
def: "A heterodimeric transcription factor complex composed of the bZIP proteins atf1 and pcr1. The heterodimer binds m26 sites (homologous to CRE)." [PMID:24224056]
is_a: GO:0035976 ! AP1 complex
created_by: al
creation_date: 2013-11-28T11:40:28Z

[Term]
id: GO:1990244
name: histone kinase activity (H2A-T120 specific)
namespace: molecular_function
def: "Catalysis of the transfer of a phosphate group to the threonine-120 residue of histone H2A." [PMID:24140421]
synonym: "histone threonine kinase activity (H2A-T120 specific)" EXACT []
is_a: GO:0035184 ! histone threonine kinase activity
relationship: part_of GO:1990245 ! histone H2A-T120 phosphorylation
created_by: sp
creation_date: 2013-12-04T06:38:32Z

[Term]
id: GO:1990245
name: histone H2A-T120 phosphorylation
namespace: biological_process
def: "The modification of histone H2A by the addition of a phosphate group to a threonine residue at position 120 of the histone." [PMID:24140421]
synonym: "histone H2A phosphorylation at T120" EXACT []
synonym: "histone H2AT120 phosphorylation" EXACT []
is_a: GO:0035405 ! histone-threonine phosphorylation
is_a: GO:1990164 ! histone H2A phosphorylation
created_by: sp
creation_date: 2013-12-04T06:41:30Z

[Term]
id: GO:1990246
name: uniplex complex
namespace: cellular_component
def: "A calcium channel complex in the mitochondrial inner membrane capable of highly-selective calcium channel activity. Its components include the EF-hand-containing proteins mitochondrial calcium uptake 1 (MICU1) and MICU2, the pore-forming subunit mitochondrial calcium uniporter (MCU) and its paralog MCUb, and the MCU regulator EMRE." [PMID:24231807]
synonym: "mitochondrial uniporter complex" EXACT []
synonym: "mitochondrial uniporter holocomplex" EXACT []
is_a: GO:0034704 ! calcium channel complex
is_a: GO:0098800 ! inner mitochondrial membrane protein complex
relationship: part_of GO:0005743 ! mitochondrial inner membrane
created_by: sp
creation_date: 2013-12-04T06:44:35Z

[Term]
id: GO:1990247
name: N6-methyladenosine-containing RNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA molecule modified by N6-methyladenosine (m6A), a modification present at internal sites of mRNAs and some non-coding RNAs." [PMID:22575960, PMID:24284625]
is_a: GO:0003723 ! RNA binding
created_by: sp
creation_date: 2013-12-04T06:55:29Z

[Term]
id: GO:1990248
name: regulation of transcription from RNA polymerase II promoter in response to DNA damage
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of DNA damage." [PMID:15660129]
is_a: GO:0006974 ! cellular response to DNA damage stimulus
is_a: GO:0043618 ! regulation of transcription from RNA polymerase II promoter in response to stress
created_by: pg
creation_date: 2013-12-04T13:28:04Z

[Term]
id: GO:1990249
name: nucleotide-excision repair, DNA damage recognition complex
namespace: cellular_component
def: "A protein complex that is capable of identifying lesions in DNA, such as pyrimidine-dimers, intrastrand cross-links, and bulky adducts. The wide range of substrate specificity suggests that the repair complex recognizes distortions in the DNA helix. It subsequently recruits a nucleotide-excision repair, preincision complex." [GOC:bhm, PMID:22331906]
is_a: GO:0043234 ! protein complex
created_by: bhm
creation_date: 2013-12-05T16:26:51Z

[Term]
id: GO:1990250
name: transcription-coupled nucleotide-excision repair, DNA damage recognition complex
namespace: cellular_component
def: "A protein complex that is capable of identifying lesions in DNA on the actively transcribed strand of the DNA duplex as well as a small subset of lesions not recognized by the general nucleotide-excision repair pathway. The wide range of substrate specificity suggests that the repair complex recognizes distortions in the DNA helix. It subsequently recruits a nucleotide-excision repair, preincision complex." [GOC:bhm, PMID:22331906]
is_a: GO:1990249 ! nucleotide-excision repair, DNA damage recognition complex
created_by: bhm
creation_date: 2013-12-05T16:28:45Z

[Term]
id: GO:1990251
name: Mmi1 nuclear focus complex
namespace: cellular_component
def: "A protein complex that forms during vegetative growth and is involved in the selective degradation of meiosis-specific transcripts. Contains at least Mmi1, or an ortholog of it." [GOC:al, GOC:vw, PMID:16823445, PMID:23980030]
synonym: "Mmi1 nuclear focus" BROAD []
synonym: "nuclear body" RELATED []
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part
created_by: al
creation_date: 2013-12-09T12:07:46Z

[Term]
id: GO:1990252
name: Syp1 complex
namespace: cellular_component
def: "A protein complex that contributes to the endocytic process and bud growth in yeast. It is involved in the precise timing of actin assembly during endocytosis." [GOC:bhm, PMID:19713939]
synonym: "Syp1 dimer" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044433 ! cytoplasmic vesicle part
relationship: part_of GO:0045334 ! clathrin-coated endocytic vesicle
created_by: bhm
creation_date: 2013-12-09T14:43:00Z

[Term]
id: GO:1990253
name: cellular response to leucine starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of leucine." [PMID:19033384]
xref: CHEBI:25017
is_a: GO:0034198 ! cellular response to amino acid starvation
created_by: al
creation_date: 2013-12-10T11:55:10Z

[Term]
id: GO:1990254
name: keratin filament binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a keratin filament, an intermediate filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells." [GOC:krc, PMID:6170061]
is_a: GO:0019215 ! intermediate filament binding
created_by: tb
creation_date: 2013-12-13T22:05:25Z

[Term]
id: GO:1990255
name: subsynaptic reticulum organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a subsynaptic reticulum. A subsynaptic reticulum is an elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane." [PMID:21041451]
is_a: GO:0006996 ! organelle organization
created_by: tb
creation_date: 2013-12-13T23:05:21Z

[Term]
id: GO:1990256
name: signal clustering
namespace: biological_process
def: "Grouping of multiple copies of a signal at a cellular location. May promote receptor clustering and alter the signal transduction response." [GOC:als, PMID:12011072, PMID:15603739]
synonym: "ligand clustering" BROAD [GOC:als]
is_a: GO:0009966 ! regulation of signal transduction
created_by: tb
creation_date: 2013-12-18T01:13:59Z

[Term]
id: GO:1990257
name: piccolo-bassoon transport vesicle
namespace: cellular_component
def: "A cytoplasmic dense-core vesicle that transports a range of proteins including piccolo, bassoon, N-cadherin and syntaxin. The transported proteins may be associated with the external side of the vesicle, rather than being contained within the vesicle, therefore forming an aggregate of vesicle and proteins. Piccolo-bassoon transport vesicles (or PTVs) range in size from approximately 80 nm in diameter for dense core vesicles to 130 nm by 220 nm in area for aggregates. They are packaged via the trans-Golgi network before being transported through the axon." [GOC:dr, PMID:21569270]
synonym: "PTV" RELATED []
is_a: GO:0031410 ! cytoplasmic vesicle
created_by: pr
creation_date: 2013-12-19T14:12:09Z

[Term]
id: GO:1990258
name: histone glutamine methylation
namespace: biological_process
def: "The modification of a histone by addition of a methyl group to an glutamine residue." [PMID:24352239]
is_a: GO:0016571 ! histone methylation
is_a: GO:0018364 ! peptidyl-glutamine methylation
created_by: sp
creation_date: 2014-01-02T15:08:02Z

[Term]
id: GO:1990259
name: histone-glutamine methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + (histone)-glutamine = S-adenosyl-L-homocysteine + (histone)-N5-methyl-glutamine." [PMID:24352239]
is_a: GO:0036009 ! protein-glutamine N-methyltransferase activity
is_a: GO:0042054 ! histone methyltransferase activity
created_by: sp
creation_date: 2014-01-02T15:10:29Z

[Term]
id: GO:1990260
name: negative regulation of transcription from RNA polymerase II promoter by transcription factor localization involved in response to DNA damage checkpoint signaling
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter using a mechanism that involves the localization of a transcription factor and initiated in response to the DNA damage checkpoint signaling." [PMID:24006488]
is_a: GO:0010621 ! negative regulation of transcription by transcription factor localization
relationship: part_of GO:0072423 ! response to DNA damage checkpoint signaling
created_by: al
creation_date: 2014-01-07T17:10:11Z

[Term]
id: GO:1990261
name: pre-mRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the unspliced pre-mRNA (pre-messenger RNA)." [GOC:rb, PMID:22844259]
synonym: "pre-mRNA decay" EXACT []
synonym: "unspliced RNA decay" EXACT []
is_a: GO:0006401 ! RNA catabolic process
created_by: rb
creation_date: 2014-01-07T23:06:44Z

[Term]
id: GO:1990262
name: anti-Mullerian hormone signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of anti-Mullerian hormone to its receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:hjd, PMID:23624077]
comment: An example of this is Amhr2 in M. musculus (Q8K592) a receptor for anti-mullerian hormone, described in PMID:23624077.
is_a: GO:0007166 ! cell surface receptor signaling pathway
created_by: hjd
creation_date: 2014-01-08T20:42:09Z

[Term]
id: GO:1990263
name: MAPK cascade in response to starvation
namespace: biological_process
def: "A MAPK cascade that occurs as a result of deprivation of nourishment." [GOC:al, PMID:7501024]
synonym: "MAPK cascade involved in nutrient response signaling" EXACT [GOC:al]
is_a: GO:0009267 ! cellular response to starvation
is_a: GO:0051403 ! stress-activated MAPK cascade
created_by: al
creation_date: 2014-01-09T12:27:52Z

[Term]
id: GO:1990264
name: peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
namespace: biological_process
def: "Any peptidyl-tyrosine dephosphorylation that is involved in inactivation of protein kinase activity." [PMID:7501024]
is_a: GO:0035335 ! peptidyl-tyrosine dephosphorylation
relationship: part_of GO:0006469 ! negative regulation of protein kinase activity
created_by: al
creation_date: 2014-01-09T14:28:41Z

[Term]
id: GO:1990265
name: platelet-derived growth factor complex
namespace: cellular_component
def: "A protein complex consisting of two chains of platelet-derived growth factor (PDGF) subunits. PDGF dimers bind to PDGF receptors in the plasma membrane and induce receptor dimerisation and activation. PDGFs are involved in a wide variety of signalling processes. PDGFs are found in all vertebrates where at least 2 different chains (A and B) exist. In human (and other mammals), four types of PDGF chains (A, B, C, and D) are known which form five different dimers (AA, AB, BB, CC and DD)." [GOC:bhm, IntAct:EBI-2881436, IntAct:EBI-2881443, IntAct:EBI-2881451, PMID:11331882]
comment: An example of this is PDGFA in human (P04085) in PMID:20534510 (inferred from direct assay).
synonym: "PDGF complex" RELATED []
synonym: "PDGF-AA dimer" NARROW []
synonym: "PDGF-AB dimer" NARROW []
synonym: "PDGF-BB dimer" NARROW []
synonym: "PDGF-CC dimer" NARROW []
synonym: "PDGF-DD dimer" NARROW []
xref: IntAct:EBI-2881436
xref: IntAct:EBI-2881443
xref: IntAct:EBI-2881451
is_a: GO:0036454 ! growth factor complex
created_by: bhm
creation_date: 2014-01-09T16:09:11Z

[Term]
id: GO:1990266
name: neutrophil migration
namespace: biological_process
def: "The movement of an neutrophil within or between different tissues and organs of the body." [PMID:1826836]
is_a: GO:0097530 ! granulocyte migration
created_by: sl
creation_date: 2014-01-10T00:17:47Z

[Term]
id: GO:1990267
name: response to transition metal nanoparticle
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transition metal nanoparticle." [PMID:23150627]
synonym: "response to colloidal metal" RELATED []
synonym: "response to neutral metal atoms" RELATED []
is_a: GO:0042221 ! response to chemical
created_by: sl
creation_date: 2014-01-10T17:16:41Z

[Term]
id: GO:1990268
name: response to gold nanoparticle
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gold nanoparticle stimulus." [PMID:23150627]
is_a: GO:1990267 ! response to transition metal nanoparticle
created_by: sl
creation_date: 2014-01-10T17:37:34Z

[Term]
id: GO:1990269
name: RNA polymerase II C-terminal domain phosphoserine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with phosphorylated serine residues in the C-terminal domain of RNA polymerase II." [GOC:di, PMID:22796944]
synonym: "RNA Pol II C-terminal domain phosphoserine binding" EXACT [GOC:di]
is_a: GO:0001099 ! basal RNA polymerase II transcription machinery binding
is_a: GO:0050815 ! phosphoserine binding
created_by: tb
creation_date: 2014-01-11T00:34:59Z

[Term]
id: GO:1990270
name: platelet-derived growth factor receptor-ligand complex
namespace: cellular_component
def: "A tetrameric protein complex consisting of two platelet-derived growth factor (PDGF) receptor subunits and two PDGF ligand subunits. Binding of the PDGF ligand dimer to the PDGF receptor in the plasma membrane induces receptor dimerisation and activation. PDGFs are involved in a wide variety of signalling processes and are found in all vertebrates. At least two different receptor chains (A and B) and four types of ligand chains (A, B, C, and D) are known forming a wide variety of combinations of receptor-ligand complexes." [GOC:bhm, IntACT:EBI-9080360, PMID:11331882]
comment: An example of this is PDGFA-PGFRA in human (UniProt symbols P04085, P16234) in PMID:7679113 (inferred from direct assay).
synonym: "PDGF complex" BROAD []
synonym: "PDGF receptor-ligand complex" EXACT []
synonym: "PDGF-AA-receptor alpha complex" NARROW []
synonym: "PDGF-AB-receptor alpha complex" NARROW []
synonym: "PDGF-AB-receptor beta complex" NARROW []
synonym: "PDGF-BB-receptor alpha complex" NARROW []
synonym: "PDGF-BB-receptor alpha-beta complex" NARROW []
synonym: "PDGF-BB-receptor beta complex" NARROW []
synonym: "PDGF-CC-receptor alpha complex" NARROW []
synonym: "PDGF-CC-receptor alpha-beta complex" NARROW []
synonym: "PDGF-CC-receptor beta complex" NARROW []
synonym: "PDGF-DD-receptor alpha-beta complex" NARROW []
synonym: "PDGF-DD-receptor beta complex" NARROW []
synonym: "receptor-ligand complex" BROAD []
xref: IntAct:EBI-9080360
is_a: GO:0098797 ! plasma membrane protein complex
relationship: has_part GO:0043235 ! receptor complex
relationship: has_part GO:1990265 ! platelet-derived growth factor complex
relationship: part_of GO:0005887 ! integral component of plasma membrane
created_by: bhm
creation_date: 2014-01-14T11:12:22Z

[Term]
id: GO:1990271
name: obsolete anti-Mullerian hormone
namespace: molecular_function
def: "OBSOLETE. Combining with anti-Mullerian hormone to initiate a change in cell activity." [GOC:hjd, PMID:23624077]
comment: An example of this is Amdh2 in M. musculus, UniprotKB:Q8K592-1 in PMID:23624077.
subset: termgenie_unvetted
synonym: "anti-Mullerian hormone" EXACT []
is_obsolete: true
created_by: hjd
creation_date: 2014-01-14T20:38:39Z

[Term]
id: GO:1990272
name: anti-Mullerian hormone receptor activity
namespace: molecular_function
def: "Combining with anti-Mullerian hormone to initiate a change in cell activity." [GOC:hjd, PMID:23624077]
comment: An example of this is Amdh2 in M. musculus, UniprotKB:Q8K592-1 in PMID:23624077.
is_a: GO:0016500 ! protein-hormone receptor activity
relationship: part_of GO:1990262 ! anti-Mullerian hormone signaling pathway
created_by: hjd
creation_date: 2014-01-14T21:41:35Z

[Term]
id: GO:1990273
name: snRNA 5'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 5' end of an snRNA molecule." [PMID:22740346]
is_a: GO:0016180 ! snRNA processing
is_a: GO:0034471 ! ncRNA 5'-end processing
created_by: al
creation_date: 2014-01-15T15:32:06Z

[Term]
id: GO:1990274
name: mitotic actomyosin contractile ring disassembly
namespace: biological_process
def: "Any disaggregation of an actomyosin contractile ring into its constituent components that is involved in a mitotic cell cycle." [PMID:14602073, PMID:22891673]
synonym: "mitotic actomyosin ring disassembly" RELATED []
synonym: "mitotic CAR disassembly" EXACT []
synonym: "mitotic constriction ring disassembly" RELATED []
synonym: "mitotic contractile actomyosin ring disassembly" EXACT []
synonym: "mitotic cytokinetic ring disassembly" RELATED []
is_a: GO:1902410 ! mitotic cytokinetic process
is_a: GO:1902621 ! actomyosin contractile ring disassembly
intersection_of: GO:1902621 ! actomyosin contractile ring disassembly
intersection_of: part_of GO:0000281 ! mitotic cytokinesis
relationship: part_of GO:0000281 ! mitotic cytokinesis
created_by: mah
creation_date: 2014-01-16T10:25:42Z

[Term]
id: GO:1990275
name: preribosome binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any part of a preribosome." [GOC:di, PMID:22735702]
is_a: GO:0043021 ! ribonucleoprotein complex binding
created_by: tb
creation_date: 2014-01-16T19:14:50Z

[Term]
id: GO:1990276
name: RNA 5'-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the 5'-gamma-phosphate in an RNA molecule." [GOC:al, GOC:vw, PMID:22740346]
is_a: GO:0008173 ! RNA methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
created_by: pr
creation_date: 2014-01-28T09:44:16Z

[Term]
id: GO:1990277
name: parasexual conjugation with cellular fusion
namespace: biological_process
def: "A conjugation process that results in the union of cellular and genetic information from compatible mating types, without the formation of zygotes. An example of this process is found in Candida albicans." [GOC:di]
synonym: "mating" BROAD []
is_a: GO:0000746 ! conjugation
created_by: pr
creation_date: 2014-01-28T10:30:20Z

[Term]
id: GO:1990278
name: obsolete positive regulation of MBF transcription factor activity
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of activity of the transcription factor MBF." [PMID:11795845]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
subset: termgenie_unvetted
synonym: "positive regulation of MBF transcription factor activity" EXACT []
is_obsolete: true
created_by: al
creation_date: 2014-01-29T14:43:44Z

[Term]
id: GO:1990279
name: obsolete negative regulation of MBF transcription factor activity
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor MBF." [PMID:24006488]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
subset: termgenie_unvetted
synonym: "negative regulation of MBF transcription factor activity" EXACT []
is_obsolete: true
created_by: al
creation_date: 2014-01-29T14:46:52Z

[Term]
id: GO:1990280
name: RNA localization to chromatin
namespace: biological_process
def: "A process in which RNA is transported to and maintained in a part of a chromosome that is organized into chromatin." [GOC:dos, GOC:mah, PMID:22582262]
synonym: "RNA localisation to chromatin" EXACT []
is_a: GO:0006403 ! RNA localization
created_by: mah
creation_date: 2014-01-30T15:55:34Z

[Term]
id: GO:1990281
name: efflux pump complex
namespace: cellular_component
def: "A protein complex that is capable of efflux transmembrane transporter activity." [GOC:dos, PMID:21556065, PMID:9417051]
synonym: "efflux pump" EXACT []
synonym: "efflux transmembrane transporter complex" EXACT []
is_a: GO:1902495 ! transmembrane transporter complex
created_by: tt
creation_date: 2014-01-31T08:19:53Z

[Term]
id: GO:1990294
name: peptidyl-threonine trans-autophosphorylation
namespace: biological_process
def: "The phosphorylation of a peptidyl-threonine to form peptidyl-O-phospho-L-threonine on an identical protein. For example, phosphorylation by the other kinase within a homodimer." [PMID:19357077]
is_a: GO:0018107 ! peptidyl-threonine phosphorylation
is_a: GO:0036290 ! protein trans-autophosphorylation
created_by: al
creation_date: 2014-02-05T12:42:46Z

[Term]
id: GO:1990295
name: post-anaphase microtubule array
namespace: cellular_component
def: "A cytoskeletal part that consists of an array of microtubules and associated molecules that forms at the end of anaphase, and in which microtubules are nucleated from an equatorial microtubule organizing center." [PMID:11792817, PMID:17072892, PMID:9601091]
comment: The best-characterized example is found in the fission yeast Schizosaccharomyces pombe. The eMTOC is cortical, but the post-anaphase array microtubules are not exclusively cortical.
synonym: "PAA" EXACT []
synonym: "post-anaphase array" EXACT []
is_a: GO:0044430 ! cytoskeletal part
relationship: has_part GO:0000923 ! equatorial microtubule organizing center
relationship: part_of GO:0015630 ! microtubule cytoskeleton
created_by: mah
creation_date: 2014-02-20T13:54:23Z

[Term]
id: GO:1990296
name: scaffoldin complex
namespace: cellular_component
def: "A protein complex that contains one or more scaffoldin proteins and several cellulosomal enzymes." [PMID:15197390, PMID:20373916]
xref: GOC:mengo_curators
is_a: GO:0043234 ! protein complex
is_a: GO:0044421 ! extracellular region part
is_a: GO:0044422 ! organelle part
relationship: part_of GO:0043263 ! cellulosome
created_by: tt
creation_date: 2014-02-25T15:06:43Z

[Term]
id: GO:1990297
name: renal amino acid absorption
namespace: biological_process
def: "A renal system process in which amino acids are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures." [GOC:hjd, PMID:1526373]
is_a: GO:0070293 ! renal absorption
created_by: hjd
creation_date: 2014-02-25T22:05:57Z

[Term]
id: GO:1990298
name: bub1-bub3 complex
namespace: cellular_component
def: "Protein complex that associates with the kinetochores." [PMID:22521786]
is_a: GO:0043234 ! protein complex
created_by: al
creation_date: 2014-02-26T09:23:04Z

[Term]
id: GO:1990299
name: Bub1-Bub3 complex localization to kinetochore
namespace: biological_process
def: "A cellular protein complex localization that acts on a Bub1-Bub3 complex; as a result, the complex is transported to, or maintained in, a specific location at the kinetochore." [PMID:22521786]
is_a: GO:0034501 ! protein localization to kinetochore
is_a: GO:0034629 ! cellular protein complex localization
created_by: al
creation_date: 2014-02-26T09:29:13Z

[Term]
id: GO:1990300
name: cellulosome binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the cellulosome, an extracellular multi-enzyme complex containing several enzymes aligned on a non-catalytic scaffolding that functions to hydrolyze plant cell wall polysaccharides." [PMID:11893054, PMID:15197390]
xref: GOC:mengo_curators
is_a: GO:0032403 ! protein complex binding
created_by: tt
creation_date: 2014-02-26T22:41:22Z

[Term]
id: GO:1990301
name: scaffoldin complex binding
namespace: molecular_function
def: "A protein complex that contains one or more scaffoldin proteins and several cellulosomal enzymes ant that interacts selectively and non-covalently with the scaffoldin complex." [PMID:11893054, PMID:15197390]
xref: GOC:mengo_curators
is_a: GO:0032403 ! protein complex binding
created_by: tt
creation_date: 2014-02-26T22:50:37Z

[Term]
id: GO:1990302
name: Bre1-Rad6 ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex consisting of Bre1 and Rad6 that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. It thereby plays a central role in histone code and gene regulation. It also modulates the formation of double-strand breaks during meiosis." [GOC:bhm, IntAct:EBI-9102228, PMID:19531475]
comment: This complex has been identified in Saccharomyces cerevisiae (P19812) - see PMID:19531475 (inferred from direct assay).
synonym: "Bre1-Rad6 complex" EXACT []
is_a: GO:0000151 ! ubiquitin ligase complex
relationship: part_of GO:0005622 ! intracellular
created_by: bhm
creation_date: 2014-02-28T16:50:34Z

[Term]
id: GO:1990303
name: UBR1-RAD6 ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex consisting of UBR1 and RAD6 components. It polyubiquitinates proteins containing non-acetylated N-terminal residues causing their subsequent degradation by the proteasome as part of the Ac/N-End Rule pathway. It recognizes non-acetylated N-terminal methionine if it is followed by a hydrophobic residue. Additionally, it acts in an N-end rule independent manner as a component of a novel quality control pathway for proteins synthesized on cytosolic ribosomes." [GOC:bhm, IntAct:EBI-9103673, PMID:19531475]
comment: This complex has been identified in Saccharomyces cerevisiae (P19812) - see PMID:19531475 (inferred from direct assay).
synonym: "UBR1-RAD6 complex" EXACT []
is_a: GO:0000151 ! ubiquitin ligase complex
relationship: part_of GO:0005622 ! intracellular
created_by: bhm
creation_date: 2014-03-03T21:43:49Z

[Term]
id: GO:1990304
name: MUB1-RAD6-UBR2 ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex consisting of MUB1, RAD6 and UBR2 components. It ubiquitinates, and targets for destruction, the RPN4 transcription factor, which upregulates the proteasome genes. The binding of MUB1 may position the RPN4 ubiquitylation site proximal to the Ubiquitin-RAD6 thioester and allow the transfer of Ubiquitin from RAD6 to RPN4. One of its components, MUB1, is a short-lived protein ubiquitinated by the UBR2-RAD6 ubiquitin conjugating enzyme." [GOC:bhm, IntAct:EBI-9117531, PMID:18070918]
comment: This complex has been identified in Saccharomyces cerevisiae (UniProt symbol P19812) - see PMID:18070918.
is_a: GO:0000151 ! ubiquitin ligase complex
relationship: part_of GO:0005622 ! intracellular
created_by: bhm
creation_date: 2014-03-03T21:54:21Z

[Term]
id: GO:1990305
name: RAD6-UBR2 ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex consisting of RAD6 and UBR2 components. It may act in a quality control pathway for proteins synthesized on cytosolic ribosomes. The UBR2 component lacks sequence motifs required for N-end rule degradation." [GOC:bhm, IntAct:EBI-9116509, PMID:15504724]
comment: This complex has been identified in Saccharomyces cerevisiae (P19812) - see PMID:15504724
synonym: "RAD6-UBR2 complex" EXACT []
is_a: GO:0000151 ! ubiquitin ligase complex
relationship: part_of GO:0005622 ! intracellular
created_by: bhm
creation_date: 2014-03-03T22:14:32Z

[Term]
id: GO:1990306
name: RSP5-BUL ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex consisting of RSP5 and BUL components. It polyubiquinates plasma membrane transporters and permeases, required for their endocytosis and subsequent degradation in the vacuole. BUL1 or BUL2, respectively, bind to the target protein, enabling ubiquitylation by Rsp5. Phosphorylation of BUL proteins results in binding to 14-3-3 proteins, protecting the permeases from down-regulation." [GOC:bhm, IntAct:EBI-9105217, IntAct:EBI-9105295, PMID:9931424]
comment: This complex has been identified in Saccharomyces cerevisiae (P19812) - see PMID:9931424
synonym: "RSP5-BUL1 complex" EXACT []
synonym: "RSP5-BUL2 complex" RELATED []
is_a: GO:0000151 ! ubiquitin ligase complex
relationship: part_of GO:0005622 ! intracellular
created_by: bhm
creation_date: 2014-03-03T22:53:01Z

[Term]
id: GO:1990308
name: Type-I dockerin domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type-I dockerin domain of a protein. Type-I dockerin domain is the binding partner of type-1 cohesin domain." [PMID:23195689, PMID:24080387]
xref: GOC:mengo_curators
is_a: GO:0019904 ! protein domain specific binding
created_by: tt
creation_date: 2014-03-07T03:10:37Z

[Term]
id: GO:1990309
name: Type-II dockerin domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type-II dockerin domain of a protein. Type-II dockerin domain is the binding partner of type-II cohesin domain." [PMID:23195689, PMID:24080387]
xref: GOC:mengo_curators
is_a: GO:0019904 ! protein domain specific binding
created_by: tt
creation_date: 2014-03-07T03:16:49Z

[Term]
id: GO:1990310
name: Type-III dockerin domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type-III dockerin domain of a protein. Type-III dockerin domain is the binding partner of type-III cohesin domain." [PMID:23195689, PMID:24080387]
xref: GOC:mengo_curators
is_a: GO:0019904 ! protein domain specific binding
created_by: tt
creation_date: 2014-03-07T03:22:36Z

[Term]
id: GO:1990311
name: Type-I cohesin domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type-I cohesin domain of a protein. Type-I cohesin domain is the binding partner of type-I dockerin domain." [PMID:23195689, PMID:24080387]
xref: GOC:mengo_curators
is_a: GO:0019904 ! protein domain specific binding
created_by: tt
creation_date: 2014-03-07T04:47:31Z

[Term]
id: GO:1990312
name: Type-II cohesin domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type-II cohesin domain of a protein. Type-II cohesin domain is the binding partner of type-II dockerin domain." [PMID:23195689, PMID:24080387]
xref: GOC:mengo_curators
is_a: GO:0019904 ! protein domain specific binding
created_by: tt
creation_date: 2014-03-07T04:51:07Z

[Term]
id: GO:1990313
name: Type-III cohesin domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type-III cohesin domain of a protein. Type-III cohesin domain is the binding partner of type-III dockerin domain." [PMID:23195689, PMID:24080387]
xref: GOC:mengo_curators
is_a: GO:0019904 ! protein domain specific binding
created_by: tt
creation_date: 2014-03-07T04:58:07Z

[Term]
id: GO:1990314
name: cellular response to insulin-like growth factor stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin-like growth factor stimulus." [PMID:20042609]
synonym: "cellular response to insulin-like growth factor" EXACT []
is_a: GO:0071375 ! cellular response to peptide hormone stimulus
created_by: sl
creation_date: 2014-03-07T19:38:21Z

[Term]
id: GO:1990315
name: Mcs4 RR-MAPKKK complex
namespace: cellular_component
def: "A protein complex that consists of a phospho relay component and a MAPK cascade component.  The complex is involved in signaling oxidative stress and osmostress." [PMID:24255738]
comment: In S. pombe it consists of Mpr1, Tdh1, Mcs4, Win1, Wis4 and Wis1.
is_a: GO:0043234 ! protein complex
created_by: al
creation_date: 2014-03-14T09:59:45Z

[Term]
id: GO:1990316
name: ATG1/ULK1 kinase complex
namespace: cellular_component
alt_id: GO:0034273
alt_id: GO:0070969
def: "A protein complex consisting of ATG1/ULK1 and ATG13 along with other proteins that regulate its function (e.g. ATG17 in yeast or RB1CC1(FIP200) in mammals). This complex has serine/threonine protein kinase activity and is involved in autophagosome formation." [GOC:bhm, GOC:DOS, GOC:rb, IntAct:EBI-2352849, PMID:15743910, PMID:19211835, PMID:19258318, PMID:19597335, PMID:22885598]
synonym: "ATG1 kinase complex" EXACT []
synonym: "ATG1-ATG13 complex" EXACT []
synonym: "ATG1/ULK1 signaling complex" EXACT []
synonym: "Atg1p signalling complex" EXACT []
synonym: "autophagy-initiation complex" EXACT [GOC:autophagy, GOC:pad, GOC:PARL, PMID:26754330]
synonym: "ULK1 signaling complex" EXACT []
synonym: "ULK1-ATG13-FIP200 complex" EXACT []
synonym: "ULK1-ATG13-RB1CC1 complex" EXACT [GOC:curators]
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:1902554 ! serine/threonine protein kinase complex
created_by: bhm
creation_date: 2014-03-14T10:55:11Z

[Term]
id: GO:1990317
name: Gin4 complex
namespace: cellular_component
def: "A protein complex involved in septin ring formation during mitosis. In Saccharomyces cerevisiae it consists of BNI5, CDC3, CDC10, CDC11, CDC12, GIN4, NAP1 and SHS1. At least 2 GIN4 molecules are involved." [GOC:bhm, IntAct:EBI-2431392, PMID:12058072]
synonym: "Gin4-septin complex" EXACT []
is_a: GO:0032155 ! cell division site part
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044448 ! cell cortex part
is_a: GO:1902554 ! serine/threonine protein kinase complex
relationship: part_of GO:0000144 ! cellular bud neck septin ring
created_by: bhm
creation_date: 2014-03-14T12:07:05Z

[Term]
id: GO:1990318
name: collagen type XIX trimer
namespace: cellular_component
def: "A collagen homotrimer of alpha1(XIX) chains; type XIX collagen triple helices localize to basement membrane zones in differentiating muscle cells." [GOC:bhm, IntAct:EBI-2529092, PMID:17876790]
is_a: GO:0005593 ! FACIT collagen trimer
is_a: GO:0098651 ! basement membrane collagen trimer
relationship: part_of GO:0005604 ! basement membrane
created_by: bhm
creation_date: 2014-03-14T16:05:57Z

[Term]
id: GO:1990319
name: collagen type XX trimer
namespace: cellular_component
def: "A collagen homotrimer of alpha1(XX) chains." [GOC:bhm, IntAct:EBI-2529132, PMID:17876790]
is_a: GO:0005593 ! FACIT collagen trimer
created_by: bhm
creation_date: 2014-03-14T16:31:21Z

[Term]
id: GO:1990320
name: collagen type XXI trimer
namespace: cellular_component
def: "A collagen homotrimer of alpha1(XXI) chains; type XXI collagen triple helices found in the extracellular matrix component of blood vessel walls and in the cytoplasm of cultured human aortic smooth muscle." [GOC:bhm, IntAct:EBI-2529143, PMID:17876790]
is_a: GO:0005593 ! FACIT collagen trimer
created_by: bhm
creation_date: 2014-03-14T16:40:14Z

[Term]
id: GO:1990321
name: collagen type XXII trimer
namespace: cellular_component
def: "A collagen homotrimer of alpha1(XXII) chains; type XXII collagen triple helices acts as a cell adhesion ligand for skin epithelial cells and fibroblasts." [GOC:bhm, IntAct:EBI-2529189, PMID:17876790]
is_a: GO:0005593 ! FACIT collagen trimer
created_by: bhm
creation_date: 2014-03-14T16:50:05Z

[Term]
id: GO:1990322
name: collagen type XXIII trimer
namespace: cellular_component
def: "A collagen homotrimer of alpha1(XXIII) chains; type XXIII collagen triple helices span the plasma membrane." [GOC:bhm, IntAct:EBI-2529234, PMID:17876790]
is_a: GO:0030936 ! transmembrane collagen trimer
relationship: part_of GO:0005887 ! integral component of plasma membrane
created_by: bhm
creation_date: 2014-03-14T22:01:00Z

[Term]
id: GO:1990323
name: collagen type XXIV trimer
namespace: cellular_component
def: "A collagen homotrimer of alpha1(XXIV) chains; type XXIV collagen triple helices may participate in regulating type I collagen fibrillogenesis at specific anatomical locations during fetal development." [GOC:bhm, IntAct:EBI-2529258, PMID:17876790]
is_a: GO:0005583 ! fibrillar collagen trimer
created_by: bhm
creation_date: 2014-03-14T22:05:53Z

[Term]
id: GO:1990324
name: collagen type XXVI trimer
namespace: cellular_component
def: "A collagen homotrimer of alpha1(XXVI) chains." [GOC:bhm, IntAct:EBI-2529362, PMID:17876790]
is_a: GO:0005581 ! collagen trimer
is_a: GO:0044420 ! extracellular matrix component
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005578 ! proteinaceous extracellular matrix
created_by: bhm
creation_date: 2014-03-16T23:02:35Z

[Term]
id: GO:1990325
name: collagen type XXVII trimer
namespace: cellular_component
def: "A collagen homotrimer of alpha1(XXVII) chains. These trimers form thin, non-striated fibrils. Type XXVII collagen triple helices play a role during the calcification of cartilage and the transition of cartilage to bone." [GOC:bhm, IntAct:EBI-2529377, PMID:17876790, PMID:21421911]
is_a: GO:0005583 ! fibrillar collagen trimer
relationship: part_of GO:0005578 ! proteinaceous extracellular matrix
relationship: part_of GO:0098643 ! banded collagen fibril
created_by: bhm
creation_date: 2014-03-16T23:13:15Z

[Term]
id: GO:1990326
name: collagen type XXVIII trimer
namespace: cellular_component
def: "A collagen homotrimer of alpha1(XXVIII) chains." [GOC:bhm, IntAct:EBI-2529426, PMID:17876790]
is_a: GO:0005581 ! collagen trimer
is_a: GO:0044420 ! extracellular matrix component
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005578 ! proteinaceous extracellular matrix
created_by: bhm
creation_date: 2014-03-16T23:15:28Z

[Term]
id: GO:1990327
name: collagen type XXV trimer
namespace: cellular_component
def: "A collagen homotrimer of alpha1(XXV) chains; type XXV collagen triple helices span the plasma membrane." [GOC:bhm, IntAct:EBI-2529312, PMID:17876790]
is_a: GO:0030936 ! transmembrane collagen trimer
relationship: part_of GO:0005887 ! integral component of plasma membrane
created_by: bhm
creation_date: 2014-03-17T09:28:50Z

[Term]
id: GO:1990328
name: RNA polymerase II, RPB4-RPB7 subcomplex
namespace: cellular_component
def: "A protein complexes that mediates transcription and the two major cytoplasmic mRNA decay pathways and is required for efficient translation initiation in association with RNA polymerase II (Pol II)." [GOC:bhm, IntAct:EBI-2945755, PMID:15591044]
is_a: GO:0043234 ! protein complex
created_by: bhm
creation_date: 2014-03-17T09:37:07Z

[Term]
id: GO:1990329
name: IscS-TusA complex
namespace: cellular_component
def: "A heterotetrameric protein complex involved in the sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm5s2U) at tRNA wobble positions. In E. coli it consists of a central IscS dimer with the two TusA protomers bound to one of the IscS units each via persulfide (-SSH) groups." [GOC:bhm, IntAct:EBI-8869931, PMID:20404999]
is_a: GO:1990221 ! L-cysteine desulfurase complex
is_a: GO:1990228 ! sulfurtransferase complex
created_by: bhm
creation_date: 2014-03-17T10:00:47Z

[Term]
id: GO:1990330
name: IscS-IscU complex
namespace: cellular_component
def: "A heterotetrameric protein complex involved in the sulfur transfer during iron-sulfur cluster assembly and in the modification of tRNA wobble positions. In E. coli it consisting of a central IscS dimer with the IscU protomers attached to one of the IscS units each via a disulfide (-SSH) group." [GOC:bhm, IntAct:EBI-8870238, PMID:20404999]
is_a: GO:1990221 ! L-cysteine desulfurase complex
is_a: GO:1990228 ! sulfurtransferase complex
created_by: bhm
creation_date: 2014-03-17T10:08:19Z

[Term]
id: GO:1990331
name: Hpa2 acetyltransferase complex
namespace: cellular_component
def: "A tetrameric protein complex capable of acetyltransferase activity. It can catalyze the transfer of an acetyl group from acetyl-CoA to an acceptor residue on histone H-3, histone H-4, or on polyamines. The complex is also capable of acetylating certain small basic proteins. The two Hpa2 dimers that make up the tetramer are held together by interactions between the bound acetyl-CoA molecules." [GOC:bhm, IntAct:EBI-8871758, PMID:10600387]
is_a: GO:0070775 ! H3 histone acetyltransferase complex
is_a: GO:1902562 ! H4 histone acetyltransferase complex
created_by: bhm
creation_date: 2014-03-17T10:18:23Z

[Term]
id: GO:1990332
name: Ire1 complex
namespace: cellular_component
def: "A type-I transmembrane protein complex located in the endoplasmic reticulum (ER) consisting of an IRE1-IRE1 dimer, which forms in response to the accumulation of unfolded protein in the ER. The dimeric complex has endoribonuclease (RNase) activity and evokes the unfolded protein response (UPR) by cleaving an intron of a mRNA coding for the transcription factor HAC1 in yeast or XBP1 in mammals; the complex cleaves a single phosphodiester bond in each of two RNA hairpins (with non-specific base paired stems and loops of consensus sequence CNCNNGN, where N is any base) to remove an intervening intron from the target transcript." [GOC:bf, GOC:bhm, IntAct:EBI-8872439, PMID:18191223, PMID:25437541]
comment: An example of this is Ire1 in Escherichia coli (P32361) in PMID:18191223 (inferred from direct assay).
synonym: "ERN1 complex" RELATED [HGNC:3449]
synonym: "IRE1 dimer" EXACT [PMID:25437541]
is_a: GO:0044432 ! endoplasmic reticulum part
is_a: GO:0098796 ! membrane protein complex
is_a: GO:1902554 ! serine/threonine protein kinase complex
is_a: GO:1902555 ! endoribonuclease complex
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane
created_by: bhm
creation_date: 2014-03-17T10:46:58Z

[Term]
id: GO:1990333
name: mitotic checkpoint complex, CDC20-MAD2 subcomplex
namespace: cellular_component
def: "A protein complex involved in the spindle checkpoint, preventing the activation of the anaphase-promoting complex until all chromosomes are correctly attached in a bipolar fashion to the mitotic spindle. In budding yeast this complex consists of Mad2p and Cdc20p, and in mammalian cells it consists of MAD2 and CDC20." [GOC:bhm, IntAct:EBI-1270646, PMID:15879521]
comment: An example of this is cdc20 in Saccharomyces cerevisiae (P26309) in PMID:15879521 (inferred from direct assay).
synonym: "CDC20-MAD2 complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0033597 ! mitotic checkpoint complex
created_by: bhm
creation_date: 2014-03-17T14:11:35Z

[Term]
id: GO:1990334
name: Bfa1-Bub2 complex
namespace: cellular_component
def: "A protein complex that acts as a two-component GTPase-activating protein for Tem1 GTPase, thus regulating a signal transduction cascade, called the mitotic exit network (MEN), which is required for mitotic exit and cytokinesis. Bub2/Bfa1 keeps Tem1 inactive until the spindle is properly oriented, thus inhibiting MEN activation." [GOC:bhm, IntAct:EBI-1271344, PMID:16449187]
is_a: GO:0044450 ! microtubule organizing center part
is_a: GO:1902773 ! GTPase activator complex
relationship: part_of GO:0005816 ! spindle pole body
created_by: bhm
creation_date: 2014-03-17T14:34:21Z

[Term]
id: GO:1990335
name: process resulting in tolerance to alcohol
namespace: biological_process
def: "A response to alcohol that results in a state of tolerance to alcohol." [PMID:24014527]
xref: GOC:mengo_curators
is_a: GO:0097305 ! response to alcohol
created_by: tt
creation_date: 2014-03-20T11:02:26Z

[Term]
id: GO:1990336
name: process resulting in tolerance to butan-1-ol
namespace: biological_process
def: "A response to butan-1-ol that results in a state of tolerance to butan-1-ol." [PMID:24014527]
xref: GOC:mengo_curators
is_a: GO:1901422 ! response to butan-1-ol
created_by: tt
creation_date: 2014-03-20T11:07:00Z

[Term]
id: GO:1990337
name: process resulting in tolerance to isobutanol
namespace: biological_process
def: "A response to isobutanol that results in a state of tolerance to isobutanol." [PMID:24014527]
xref: GOC:mengo_curators
is_a: GO:1902665 ! response to isobutanol
created_by: tt
creation_date: 2014-03-20T11:10:04Z

[Term]
id: GO:1990338
name: laminin-13 complex
namespace: cellular_component
def: "A laminin complex composed of alpha4, beta2 and gamma3 polypeptide chains." [GOC:bhm, IntAct:EBI-2530020, PMID:17453709]
synonym: "laminin-423" EXACT []
is_a: GO:0043256 ! laminin complex
created_by: bhm
creation_date: 2014-03-20T23:37:11Z

[Term]
id: GO:1990339
name: laminin-14 complex
namespace: cellular_component
def: "A laminin complex composed of alpha5, beta2 and gamma2 polypeptide chains." [GOC:bhm, IntAct:EBI-2530034, PMID:17453709]
synonym: "laminin-522" EXACT []
is_a: GO:0043256 ! laminin complex
created_by: bhm
creation_date: 2014-03-20T23:41:32Z

[Term]
id: GO:1990340
name: laminin-15 complex
namespace: cellular_component
def: "A laminin complex composed of alpha5, beta2 and gamma3 polypeptide chains." [GOC:bhm, IntAct:EBI-2530049, PMID:17453709]
synonym: "laminin-523" EXACT []
is_a: GO:0043256 ! laminin complex
created_by: bhm
creation_date: 2014-03-20T23:48:25Z

[Term]
id: GO:1990341
name: thrombospondin complex
namespace: cellular_component
def: "A homotrimeric or homopentameric glycoprotein that functions at the interface of the cell membrane and the extracellular matrix through its interactions with proteins and proteoglycans, such as collagens, integrins and fibronectin, to regulate matrix structure and cellular behaviour." [GOC:bhm, IntAct:EBI-2530370, IntAct:EBI-2530917, IntAct:EBI-2530961, IntAct:EBI-2530975, IntAct:EBI-2531058, IntAct:EBI-9251379, IntAct:EBI-9251408, IntAct:EBI-9251455, IntAct:EBI-9251502, IntAct:EBI-9251524, PMID:18193164]
is_a: GO:0043234 ! protein complex
is_a: GO:0044420 ! extracellular matrix component
relationship: part_of GO:0031012 ! extracellular matrix
created_by: bhm
creation_date: 2014-03-21T14:27:07Z

[Term]
id: GO:1990342
name: heterochromatin island
namespace: cellular_component
def: "A region of heterochromatin that is formed dynamically in response to environmental signals by a process that does not require RNAi, and is enriched in histone H3 methylated on lysine 9 (H3K9me)." [PMID:22144463, PMID:24210919]
comment: An example of this type of heterochromatin is found in Schizosaccharomyces pombe, where heterochromatin islands are formed at meiotic genes during vegetative (mitotic) growth.
is_a: GO:0005720 ! nuclear heterochromatin
created_by: mah
creation_date: 2014-03-21T15:26:44Z

[Term]
id: GO:1990343
name: heterochromatin domain
namespace: cellular_component
def: "A region of heterochromatin that is formed dynamically under specific growth conditions by a process that requires RNAi, and is enriched in histone H3 methylated on lysine 9 (H3K9me)." [PMID:23151475, PMID:24210919]
comment: An example of this type of heterochromatin is found in Schizosaccharomyces pombe, where heterochromatin domains preferentially assemble at sexual differentiation genes and retrotransposons.
synonym: "HOOD" EXACT [PMID:23151475]
is_a: GO:0005720 ! nuclear heterochromatin
created_by: mah
creation_date: 2014-03-21T15:40:48Z

[Term]
id: GO:1990344
name: secondary cell septum biogenesis
namespace: biological_process
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a secondary cell septum following nuclear division." [PMID:22891259]
is_a: GO:0044085 ! cellular component biogenesis
is_a: GO:1902410 ! mitotic cytokinetic process
relationship: part_of GO:0000917 ! barrier septum assembly
relationship: part_of GO:0061640 ! cytoskeleton-dependent cytokinesis
created_by: mah
creation_date: 2014-03-24T13:24:48Z

[Term]
id: GO:1990345
name: MTREC complex
namespace: cellular_component
def: "A protein complex that consists of a heterodimer formed by Red1 and Mtl1 or homologs thereof, and that promotes degradation of mRNAs and noncoding RNAs and associates with different proteins to assemble heterochromatin via distinct mechanisms." [PMID:24210919]
comment: An example of this is the complex formed by Red1 and Mtl1 in S. pombe (UniProt symbols Q9UTR8 and O13799 respectively) in PMID:24210919 (inferred from direct assay).
synonym: "Mtl1-Red1 core complex" EXACT [PMID:24210919]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part
created_by: mah
creation_date: 2014-03-24T13:30:52Z

[Term]
id: GO:1990346
name: BID-BCL-xl complex
namespace: cellular_component
def: "A heterodimeric protein complex consisting of BID and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:bhm, IntAct:EBI-709568, IntAct:EBI-822507, IntAct:EBI-822526, PMID:14634621]
is_a: GO:0043234 ! protein complex
created_by: bhm
creation_date: 2014-03-25T00:18:41Z

[Term]
id: GO:1990347
name: obsolete G*/A mismatch-specific adenine-DNA glycosylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the removal of adenine misinserted into nascent strand opposite 8-oxoG in the template by adenine DNA glycosylase activity. The reaction leaves an apyrimidinic (AP) site." [PMID:24559510]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
subset: termgenie_unvetted
synonym: "G*/A mismatch-specific adenine-DNA glycosylase activity" EXACT []
is_obsolete: true
created_by: al
creation_date: 2014-03-25T10:14:37Z

[Term]
id: GO:1990348
name: obsolete G/A mismatch specific adenine DNA glycosylase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the removal of adenine misinserted into nascent strand opposite guanine in the template by adenine DNA glycosylase activity. The reaction leaves an apurinic AP site. I also requested same term but for Go/A mismatch. If you think it is better to make one term for mismatched adenine that is fine by me." [PMID:9737967]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
subset: termgenie_unvetted
synonym: "G/A mismatch specific adenine DNA glycosylase activity" EXACT []
is_obsolete: true
created_by: al
creation_date: 2014-03-25T10:55:45Z

[Term]
id: GO:1990349
name: gap junction-mediated intercellular transport
namespace: biological_process
def: "The movement of substances between cells via gap junctions. A gap junction is a fine cytoplasmic channel, found in animal cells, that connects the cytoplasm of one cell to that of an adjacent cell, allowing ions and other molecules to pass freely between the two cells." [GOC:hjd, PMID:14506308, PMID:23261543, Wikipedia:Gap_junction]
is_a: GO:1902585 ! single-organism intercellular transport
created_by: hjd
creation_date: 2014-03-25T18:05:44Z

[Term]
id: GO:1990350
name: glucose transporter complex
namespace: cellular_component
def: "A protein complex facilitating glucose transport into, out of or within a cell, or between cells." [GOC:bhm, IntAct:EBI-959455, IntAct:EBI-960644, IntAct:EBI-960674, PMID:15449578]
comment: An example of this is GTR1 in human (UniProt symbol P11166) in PMID:15449578 (inferred from direct assay).
is_a: GO:1990351 ! transporter complex
created_by: bhm
creation_date: 2014-03-26T14:12:05Z

[Term]
id: GO:1990351
name: transporter complex
namespace: cellular_component
def: "A protein complex facilitating transport of molecules (proteins, small molecules, nucleic acids) into, out of or within a cell, or between cells." [GOC:bhm, IntAct:EBI-959455, PMID:15449578]
comment: An example of this is GTR1 in human (UniProt symbol P11166) in PMID:15449578 (inferred from direct assay).
is_a: GO:0043234 ! protein complex
created_by: bhm
creation_date: 2014-03-26T14:23:27Z

[Term]
id: GO:1990352
name: BRE1 E3 ubiquitin ligase complex
namespace: cellular_component
def: "A homodimeric protein complex composed of the E3 ubiquitin-protein ligase BRE1. Plays a role in regulating association of RNA polymerase II with active genes." [GOC:bhm, IntAct:EBI-9102292, PMID:19531475]
comment: An example of this is BRE1 in Saccharomyces cerevisiae (UniProt symbol Q07457) in PMID:19531475 (inferred from direct assay).
synonym: "BRE1 E3 ubiquitin-protein ligase complex" EXACT []
synonym: "BRE1 oligomer" EXACT []
is_a: GO:0000151 ! ubiquitin ligase complex
created_by: bhm
creation_date: 2014-03-27T13:49:05Z

[Term]
id: GO:1990353
name: Fused-Smurf ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex. In D. melanogaster, it regulates ubiquitination and proteolysis of the BMP receptor Thickveins in cystoblasts, potentially by controlling Tkv ubiquitination and degradation." [GOC:bhm, IntAct:EBI-3405462, PMID:21145463]
comment: An example of this is FUSED in Drosophila melanogaster (UniProt symbol P23647) in PMID:21145463 (inferred from direct assay).
is_a: GO:0000151 ! ubiquitin ligase complex
created_by: bhm
creation_date: 2014-03-27T14:02:09Z

[Term]
id: GO:1990354
name: activated SUMO-E1 ligase complex
namespace: cellular_component
def: "A protein complex consisting of a SUMO protein bound to a SUMO activating enzyme complex. Activation by the E1 complex and linkage to the E2 enzyme UBE2I is required for the formation of covalent bonds between SUMO and its ultimate target proteins." [GOC:bhm, Intact:EBI-9345927, PMID:15660128]
comment: An example of this is SAE1 in human (UniProt symbol Q9UBE0) in PMID:15660128 (inferred from direct assay).
synonym: "SUMO-SAE1/2 complex" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part
relationship: has_part GO:0031510 ! SUMO activating enzyme complex
created_by: bhm
creation_date: 2014-03-31T13:22:45Z

[Term]
id: GO:1990355
name: L-methionine biosynthetic process from methionine sulphoxide
namespace: biological_process
def: "The generation of L-methionine from methionine sulphoxide." [PMID:24118096]
synonym: "L-methionine salvage from methionine sulphoxide" EXACT []
synonym: "methionine salvage from methionine sulphoxide" BROAD []
is_a: GO:0071267 ! L-methionine salvage
created_by: al
creation_date: 2014-04-02T12:55:01Z

[Term]
id: GO:1990356
name: sumoylated E2 ligase complex
namespace: cellular_component
def: "A protein complex consisting of a SUMO (small ubiquitin-related modifier) protein bound to a SUMO-conjugating E2 ligase. Sumoylation of the E2 ligase is an intermediate step required for the formation of covalent bonds between a SUMO protein and its ultimate protein target. SUMO is transferred to the E2 ligase by a SUMO-activating E1 enzyme. Sumoylation of the target protein is either facilitated directly by the sumoylated E2 ligase or aided by an optional E3 ligase." [GOC:bhm, IntAct:EBI-9347978, PMID:18691969]
comment: An example of this is UBC9 in human (UniProt symbol P63279) in PMID:18691969 (inferred from direct assay).
is_a: GO:0043234 ! protein complex
created_by: bhm
creation_date: 2014-04-02T14:06:56Z

[Term]
id: GO:1990357
name: terminal web
namespace: cellular_component
def: "An actin-rich cytoskeletal network located beneath the microvilli of the apical plasma membrane of polarized epithelial cells. In addition to actin filaments, the terminal web may contain actin-binding proteins, myosin motor proteins, and intermediate filaments. The terminal web can function as a contractile structure that influences the spatial distribution of microvilli as well as the development and morphogenesis of tissues containing polarized epithelial cells." [GOC:kmv, http://en.wikipedia.org/wiki/Terminal_web, PMID:19437512, PMID:24677443, PMID:7511618]
is_a: GO:0030864 ! cortical actin cytoskeleton
created_by: pr
creation_date: 2014-04-03T14:29:59Z

[Term]
id: GO:1990358
name: xylanosome
namespace: cellular_component
def: "A multifunctional supermolecular complex, containing several proteins with hemicellulase activity. Functions to hydrolyze hemicellulose." [PMID:16769147]
synonym: "xylanolytic complex" EXACT []
xref: GOC:mengo_curators
is_a: GO:1902494 ! catalytic complex
created_by: tt
creation_date: 2014-04-05T18:08:54Z

[Term]
id: GO:1990359
name: stress response to zinc ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a zinc ion stimulus." [GOC:kmv, pmid:17888400]
synonym: "response to zinc ion stress" EXACT []
synonym: "response to zinc toxicity" RELATED []
synonym: "stress response to zinc" BROAD []
is_a: GO:0010043 ! response to zinc ion
is_a: GO:0097501 ! stress response to metal ion
created_by: kmv
creation_date: 2014-04-14T15:54:05Z

[Term]
id: GO:1990360
name: PKM2 protein kinase complex
namespace: cellular_component
def: "A protein complex capable of phosphorylating a large number of protein targets. Contributes to cell proliferation under glycose starvation conditions. In human, the complex is present as a dimer." [GOC:bhm, PMID:24606918]
synonym: "PKM2-SAICAR complex" RELATED []
synonym: "PKM2-SAICAR protein kinase complex" RELATED []
is_a: GO:1902911 ! protein kinase complex
created_by: bhm
creation_date: 2014-04-17T14:03:36Z

[Term]
id: GO:1990361
name: PKM2 pyruvate kinase complex
namespace: cellular_component
def: "A protein complex capable of pyruvate kinase activity. PKM2 only exists as homotetramer when bound to beta-d-fructofuranose 1,6-bisphosphate (CHEBI:28013)." [GOC:bhm, PMID:24606918]
comment: An example of this is PKM2 in human (P14618) in PMID:24606918 (inferred from direct assay).
synonym: "PKM2 homotetramer" EXACT []
is_a: GO:1902912 ! pyruvate kinase complex
created_by: bhm
creation_date: 2014-04-17T14:16:24Z

[Term]
id: GO:1990362
name: butanol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: butanal + NADH + H+ => n-butanol + NAD+." [GOC:mengo_curators, PMID:1999395]
xref: PMID:1999395
xref: RHEA:33200
is_a: GO:0004022 ! alcohol dehydrogenase (NAD) activity
created_by: tt
creation_date: 2014-04-23T21:14:09Z

[Term]
id: GO:1990363
name: obsolete response to hydrolysate
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of hydrolysate (any product of hydrolysis)." [GOC:mengo_curators, PMID:23356676]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
subset: termgenie_unvetted
synonym: "response to hydrolysate" EXACT []
xref: PMID:23356676
is_obsolete: true
created_by: tt
creation_date: 2014-04-23T22:12:24Z

[Term]
id: GO:1990364
name: obsolete response to aldehyde
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aldehyde." [GOC:mengo_curators, PMID:23356676]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
subset: termgenie_unvetted
synonym: "response to aldehyde" EXACT []
xref: PMID:23356676
is_obsolete: true
created_by: tt
creation_date: 2014-04-23T22:18:04Z

[Term]
id: GO:1990365
name: obsolete response to phenol
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of phenols." [GOC:mengo_curators, PMID:23356676]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
subset: termgenie_unvetted
synonym: "response to phenol" EXACT []
xref: PMID:23356676
is_obsolete: true
created_by: tt
creation_date: 2014-04-23T22:20:00Z

[Term]
id: GO:1990366
name: obsolete response to organic acid
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic acid." [GOC:mengo_curators, PMID:23356676]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
subset: termgenie_unvetted
synonym: "response to organic acid" EXACT []
xref: PMID:23356676
is_obsolete: true
created_by: tt
creation_date: 2014-04-23T22:21:26Z

[Term]
id: GO:1990367
name: process resulting in tolerance to organic substance
namespace: biological_process
def: "A response that results in a state of tolerance to an organic substance." [GOC:mengo_curators, PMID:23356676]
xref: PMID:23356676
is_a: GO:0010033 ! response to organic substance
created_by: tt
creation_date: 2014-04-23T22:25:05Z

[Term]
id: GO:1990368
name: obsolete process resulting in tolerance to hydrolysate
namespace: biological_process
def: "OBSOLETE. A response that results in a state of tolerance to hydrolysate (product of hydrolysis)." [GOC:mengo_curators, PMID:23356676]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
subset: termgenie_unvetted
synonym: "process resulting in tolerance to hydrolysate" EXACT []
xref: PMID:23356676
is_obsolete: true
created_by: tt
creation_date: 2014-04-23T22:27:51Z

[Term]
id: GO:1990369
name: process resulting in tolerance to ketone
namespace: biological_process
def: "A response that results in a state of tolerance to ketone." [GOC:mengo_curators, PMID:23356676]
xref: PMID:23356676
is_a: GO:0010033 ! response to organic substance
created_by: tt
creation_date: 2014-04-23T22:29:41Z

[Term]
id: GO:1990370
name: process resulting in tolerance to aldehyde
namespace: biological_process
def: "A response that results in a state of tolerance to aldehyde." [GOC:mengo_curators, PMID:23356676]
xref: PMID:23356676
is_a: GO:0010033 ! response to organic substance
created_by: tt
creation_date: 2014-04-23T22:30:50Z

[Term]
id: GO:1990371
name: process resulting in tolerance to phenol
namespace: biological_process
def: "A response that results in a state of tolerance to phenol." [GOC:mengo_curators, PMID:23356676]
xref: PMID:23356676
is_a: GO:0010033 ! response to organic substance
created_by: tt
creation_date: 2014-04-23T22:32:48Z

[Term]
id: GO:1990372
name: process resulting in tolerance to organic acid
namespace: biological_process
def: "A response that results in a state of tolerance to organic acid." [GOC:mengo_curators, PMID:23356676]
xref: PMID:23356676
is_a: GO:0010033 ! response to organic substance
created_by: tt
creation_date: 2014-04-23T22:34:12Z

[Term]
id: GO:1990373
name: process resulting in tolerance to alkane
namespace: biological_process
def: "A response that results in a state of tolerance to alkane." [GOC:mengo_curators, PMID:23826995]
xref: PMID:23826995
is_a: GO:1902778 ! response to alkane
created_by: tt
creation_date: 2014-04-24T00:28:50Z

[Term]
id: GO:1990374
name: Kir2 inward rectifier potassium channel complex
namespace: cellular_component
def: "A inward rectifier potassium channel complex. Homo- or heterotetramer composed of subunits of the eukaryotic Kir2 protein family. Plays a key role in maintaining the correct resting potential in eukaryotic cells." [GOC:bhm, IntAct:EBI-9510554, IntAct:EBI-9511072, PMID:16834334]
comment: An example of this is Kcnj2 in mouse (P35561) in PMID:16834334 (inferred from direct assay).
synonym: "Kir2.1 complex" NARROW []
is_a: GO:1902937 ! inward rectifier potassium channel complex
relationship: part_of GO:0005886 ! plasma membrane
created_by: bhm
creation_date: 2014-04-25T15:29:15Z

[Term]
id: GO:1990375
name: baculum development
namespace: biological_process
def: "The reproductive developmental process whose specific outcome is the progression of the baculum over time, from its formation to the mature structure." [GOC:sl, PMID:21471296]
synonym: "os penis development" EXACT [GOC:sl]
synonym: "penile bone development" EXACT [GOC:sl]
synonym: "penis bone development" EXACT [GOC:sl]
is_a: GO:0044702 ! single organism reproductive process
is_a: GO:0048608 ! reproductive structure development
is_a: GO:0060348 ! bone development
created_by: sl
creation_date: 2014-05-01T23:59:13Z

[Term]
id: GO:1990376
name: negative regulation of G1/S transition of mitotic cell cycle by positive regulation of transcription from RNA polymerase II promoter in response to nitrogen starvation
namespace: biological_process
def: "A positive regulation of transcription from RNA polymerase II promoter in response to nitrogen starvation that results in negative regulation of mitotic G1/S transition." [PMID:9135083]
is_a: GO:0036278 ! positive regulation of transcription from RNA polymerase II promoter in response to nitrogen starvation
is_a: GO:2000045 ! regulation of G1/S transition of mitotic cell cycle
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: positively_regulates GO:0100052 ! negative regulation of G1/S transition of mitotic cell cycle by transcription from RNA polymerase II promoter
relationship: positively_regulates GO:0100052 ! negative regulation of G1/S transition of mitotic cell cycle by transcription from RNA polymerase II promoter
created_by: al
creation_date: 2014-05-07T08:51:19Z

[Term]
id: GO:1990377
name: organomineral extracellular matrix
namespace: cellular_component
def: "An extracellular matrix consisting of a densely packed organomineral assembly in which the mineral phase represents the majority of the material by weight." [GOC:jh2, PMID:15994301]
comment: An example is found in shell calcitic prisms of the Mediterranean fan mussel Pinna nobilis (PMID:15994301), but the term may also be useful to annotate bone and eggshell proteins.
is_a: GO:0031012 ! extracellular matrix
created_by: pr
creation_date: 2014-05-07T10:02:28Z

[Term]
id: GO:1990378
name: upstream stimulatory factor complex
namespace: cellular_component
def: "A protein complex capable of sequence-specific DNA binding RNA polymerase II transcription factor activity through binding to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3'). Found in a variety of viral and cellular promoters." [GOC:bhm, IntAct:EBI-9518693, PMID:8576131]
comment: An example of this is USF1 in human (UniProt symbol P22415) in PMID:8576131 (inferred from direct assay).
synonym: "USF complex" EXACT []
synonym: "USF1 homodimer" NARROW []
synonym: "USF1-USF2 heterodimer" NARROW []
synonym: "USF2 homodimer" NARROW []
is_a: GO:0044798 ! nuclear transcription factor complex
relationship: part_of GO:0005634 ! nucleus
created_by: bhm
creation_date: 2014-05-07T15:41:42Z

[Term]
id: GO:1990379
name: lipid transport across blood brain barrier
namespace: biological_process
def: "The directed movement of lipid molecules passing through the blood-brain barrier." [GOC:sjp, PMID:24345162]
is_a: GO:0006869 ! lipid transport
created_by: sjp
creation_date: 2014-05-08T09:52:28Z

[Term]
id: GO:1990380
name: Lys48-specific deubiquitinase activity
namespace: molecular_function
def: "Hydrolysis of Lys48-linked ubiquitin unit(s) from a ubiquitinated protein." [GOC:bf, GOC:PARL, PMID:22970133]
synonym: "K48-specific deubiquitinase activity" EXACT [PMID:22970133]
synonym: "K48-specific deubiquitinating activity" EXACT [PMID:22970133]
is_a: GO:0101005 ! ubiquitinyl hydrolase activity
relationship: part_of GO:0071108 ! protein K48-linked deubiquitination
created_by: bf
creation_date: 2014-05-15T14:31:07Z

[Term]
id: GO:1990381
name: ubiquitin-specific protease binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a ubiquitin-specific protease." [GOC:bf, GOC:PARL, PMID:24063750]
synonym: "deubiquitinase binding" EXACT [GOC:bf]
synonym: "deubiquitinating enzyme binding" EXACT [PMID:24063750]
is_a: GO:0002020 ! protease binding
created_by: bf
creation_date: 2014-05-19T10:01:53Z

[Term]
id: GO:1990382
name: obsolete melanosome assembly
namespace: biological_process
def: "OBSOLETE. The aggregation, arrangement and bonding together of a set of components to form a melanosome, a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored." [GOC:bf, GOC:PARL, PMID:22511774]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
subset: termgenie_unvetted
synonym: "melanosome biogenesis" EXACT [PMID:22511774]
is_obsolete: true
created_by: bf
creation_date: 2014-05-20T16:06:04Z

[Term]
id: GO:1990383
name: cellular response to biotin starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of biotin." [PMID:12557275]
is_a: GO:0009267 ! cellular response to starvation
created_by: al
creation_date: 2014-05-21T10:06:58Z

[Term]
id: GO:1990384
name: hyaloid vascular plexus regression
namespace: biological_process
def: "The developmental process in which the hyaloid vascular plexus is destroyed as a part of its normal progression." [GOC:hjd, PMID:18841878]
is_a: GO:0060033 ! anatomical structure regression
relationship: part_of GO:0043010 ! camera-type eye development
created_by: hjd
creation_date: 2014-05-28T18:43:21Z

[Term]
id: GO:1990385
name: meiotic spindle midzone
namespace: cellular_component
def: "The area in the center of the meiotic spindle where the spindle microtubules from opposite poles overlap." [GOC:kmv\,PMID\:12707312]
is_a: GO:0051233 ! spindle midzone
relationship: part_of GO:0072687 ! meiotic spindle
created_by: kmv
creation_date: 2014-05-29T20:52:44Z

[Term]
id: GO:1990386
name: mitotic cleavage furrow ingression
namespace: biological_process
def: "Advancement of the mitotic cleavage furrow from the outside of the cell inward towards the center of the cell. The cleavage furrow acts as a 'purse string' which draws tight to separate daughter cells during mitotic cytokinesis and partition the cytoplasm between the two daughter cells. The furrow ingresses until a cytoplasmic bridge is formed." [GOC:kmv, PMID:12707312]
is_a: GO:0036090 ! cleavage furrow ingression
is_a: GO:1902410 ! mitotic cytokinetic process
created_by: kmv
creation_date: 2014-05-29T20:58:27Z

[Term]
id: GO:1990387
name: isogloboside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a lactosyl-ceramide derivative in which a galactose is linked to the galactose via an alpha 1,3 linkage (vs alpha 1,4 for globosides)." [GOC:hjd, PMID:22875802]
xref: CHEBI:78257
is_a: GO:0006688 ! glycosphingolipid biosynthetic process
created_by: hjd
creation_date: 2014-05-30T17:36:51Z

[Term]
id: GO:1990388
name: xylem-to-phloem iron transport
namespace: biological_process
def: "The directed movement of iron ions into the phloem from the xylem." [GOC:tb, PMID:24867923]
is_a: GO:0006826 ! iron ion transport
is_a: GO:0010233 ! phloem transport
created_by: tb
creation_date: 2014-05-30T21:06:50Z

[Term]
id: GO:1990389
name: CUE1-UBC7 ubiquitin-conjugating enzyme complex
namespace: cellular_component
def: "A protein complex capable of ubiquitin-conjugating enzyme activity during ER-associated protein degradation (ERAD). In S. cerevisiae, UBC7 is the ubiquitin-conjugating enzyme (E2) and requires binding to the ER surface by CUE1." [GOC:bhm, IntAct:EBI-9207004, PMID:23028185]
comment: An example of this is UBC7 in Saccharomyces cerevisiae (Q02159) in PMID:16179953 (inferred from direct assay).
synonym: "CUE1-UBC7 ubiquitin-conjugating enzyme (E2)" EXACT []
is_a: GO:0000835 ! ER ubiquitin ligase complex
is_a: GO:0031371 ! ubiquitin conjugating enzyme complex
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane
created_by: bhm
creation_date: 2014-06-02T15:35:58Z

[Term]
id: GO:1990390
name: protein K33-linked ubiquitination
namespace: biological_process
def: "A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 33 of the ubiquitin monomers, is added to a protein." [PMID:24768539]
is_a: GO:0000209 ! protein polyubiquitination
created_by: sp
creation_date: 2014-06-03T12:22:05Z

[Term]
id: GO:1990391
name: DNA repair complex
namespace: cellular_component
def: "A protein complex involved in DNA repair processes including direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [GOC:bhm, PMID:22749910]
synonym: "DNA damage repair complex" EXACT []
is_a: GO:0043234 ! protein complex
created_by: bhm
creation_date: 2014-06-04T09:15:24Z

[Term]
id: GO:1990392
name: EFF-1 complex
namespace: cellular_component
def: "A trimeric cell-cell fusion complex that serves as a scaffold for zippering up the extracellular domains, bringing the transmembrane segments into close proximity such that they can continue zippering within the two membranes into one. Two prefusion monomers cluster at the surface of adjacent cells. Parallel EFF-1 interactions occur across cells and a third monomer, which can come from either cell, adds on to make an intermediate, extended trimer." [GOC:bhm, IntAct:EBI-9526622, PMID:24725407]
comment: An example of this is eff-1 in C. elegans (G5ECA1) in PMID:24725407 (inferred from direct assay).
is_a: GO:0098797 ! plasma membrane protein complex
relationship: part_of GO:0005887 ! integral component of plasma membrane
created_by: bhm
creation_date: 2014-06-04T14:45:02Z

[Term]
id: GO:1990393
name: 3M complex
namespace: cellular_component
def: "A protein complex, at least composed of CUL7, CCDC8 and OBSL1, that is required for maintaining microtubule and genome integrity." [PMID:24793695, PMID:24793696]
is_a: GO:0043234 ! protein complex
created_by: sp
creation_date: 2014-06-05T06:40:49Z

[Term]
id: GO:1990394
name: cellular response to cell wall damage
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of cell wall damage. The process begins with detection of the damage and ends with a change in state or activity of the cell." [PMID:17287531]
is_a: GO:0051716 ! cellular response to stimulus
relationship: has_part GO:0071433 ! cell wall repair
created_by: al
creation_date: 2014-06-05T16:45:33Z

[Term]
id: GO:1990395
name: meiotic spindle pole body organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the meiotic spindle pole body." [GOC:vw]
is_a: GO:0051300 ! spindle pole body organization
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0000212 ! meiotic spindle organization
created_by: tb
creation_date: 2014-06-06T01:41:05Z

[Term]
id: GO:1990396
name: single-strand break repair via homologous recombination
namespace: biological_process
def: "The error-free repair of a single-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:bhm, PMID:24339919]
is_a: GO:0000012 ! single strand break repair
is_a: GO:0000725 ! recombinational repair
is_a: GO:0042275 ! error-free postreplication DNA repair
created_by: bhm
creation_date: 2014-06-09T10:47:04Z

[Term]
id: GO:1990397
name: queuosine salvage
namespace: biological_process
def: "Any process which produces queuosine from derivatives of it, without de novo synthesis." [GOC:vw, PMID:24911101]
is_a: GO:0008616 ! queuosine biosynthetic process
is_a: GO:0043174 ! nucleoside salvage
created_by: pr
creation_date: 2014-06-10T14:56:12Z

[Term]
id: GO:1990398
name: Cus cation efflux complex
namespace: cellular_component
def: "Transmembrane complex that mediates resistance to copper and silver by cation efflux directly from the cell using the proton-motive force. Spans the inner membrane, periplasm, and outer membrane. Primarily activated under anaerobic conditions by CusR and CusS but also expressed under extreme copper stress, in aerobic growth." [GOC:bhm, IntAct:EBI-9010676, PMID:23122209]
comment: An example of this is CusA in E. coli (UniProt symbol P38054) in PMID:23122209.
synonym: "copper efflux complex" NARROW []
synonym: "copper efflux system" NARROW []
synonym: "Cus cation efflux system" EXACT []
synonym: "silver efflux complex" NARROW []
synonym: "silver efflux system" NARROW []
is_a: GO:0098797 ! plasma membrane protein complex
is_a: GO:1903113 ! copper ion transmembrane transporter complex
is_a: GO:1903114 ! silver ion transmembrane transporter complex
relationship: part_of GO:0005887 ! integral component of plasma membrane
created_by: bhm
creation_date: 2014-06-11T08:51:48Z

[Term]
id: GO:1990399
name: epithelium regeneration
namespace: biological_process
def: "The regrowth of lost or destroyed epithelium." [GOC:sl, PMID:19845688]
synonym: "regeneration of epithelium" EXACT []
is_a: GO:0042246 ! tissue regeneration
is_a: GO:0060429 ! epithelium development
relationship: part_of GO:0042060 ! wound healing
created_by: sl
creation_date: 2014-06-12T17:14:42Z

[Term]
id: GO:1990400
name: mitochondrial ribosomal large subunit rRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the mitochondrial large ribosomal subunit RNA (LSU rRNA), a constituent of the mitochondrial large ribosomal subunit." [PMID:24206665]
comment: In S. cerevisiae, this is the mitochondrial 21S rRNA
synonym: "21S rRNA binding" NARROW []
synonym: "mitochondrial LSU rRNA binding" EXACT []
is_a: GO:0070180 ! large ribosomal subunit rRNA binding
created_by: mcc
creation_date: 2014-06-23T16:47:09Z

[Term]
id: GO:1990401
name: embryonic lung development
namespace: biological_process
def: "The process occurring during the embryonic phase whose specific outcome is the progression of the lung over time, from its formation to the mature structure." [PMID:24785085]
is_a: GO:0048568 ! embryonic organ development
created_by: sl
creation_date: 2014-06-23T19:56:13Z

[Term]
id: GO:1990402
name: embryonic liver development
namespace: biological_process
def: "The process occurring during the embryonic phase whose specific outcome is the progression of the liver over time, from its formation to the mature structure." [PMID:15918910]
is_a: GO:0048568 ! embryonic organ development
created_by: sl
creation_date: 2014-06-23T20:52:03Z

[Term]
id: GO:1990403
name: embryonic brain development
namespace: biological_process
def: "The process occurring during the embryonic phase whose specific outcome is the progression of the brain over time, from its formation to the mature structure." [PMID:15918910]
is_a: GO:0048568 ! embryonic organ development
created_by: sl
creation_date: 2014-06-23T20:57:13Z

[Term]
id: GO:1990404
name: protein ADP-ribosylase activity
namespace: molecular_function
def: "The transfer, from NAD, of ADP-ribose to a protein amino acid residue." [PMID:1899243, RESID:AA0040, RESID:AA0168, RESID:AA0169, RESID:AA0231, RESID:AA0237, RESID:AA0295, wikipedia:ADP-ribosylation]
synonym: "ribosylase activity" BROAD []
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups
relationship: part_of GO:0006471 ! protein ADP-ribosylation
created_by: pg
creation_date: 2014-06-24T07:04:44Z

[Term]
id: GO:1990405
name: protein antigen binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a protein antigen." [PMID:9360996]
is_a: GO:0003823 ! antigen binding
is_a: GO:0005515 ! protein binding
created_by: pm
creation_date: 2014-06-30T13:19:55Z

[Term]
id: GO:1990406
name: CGRP receptor complex
namespace: cellular_component
def: "A transmembrane, G-protein-coupled signalling receptor complex recognized by calcitonin gene-related peptides (CGRP)." [GOC:bhm, IntAct:EBI-9009008, PMID:20826335]
comment: An example of this is CALCRL in human (Q16602) in PMID:20826335 (inferred from direct assay).
synonym: "calcitonin gene-related polypeptide receptor complex" EXACT []
synonym: "Calcitonin-gene-related peptide receptor complex" EXACT []
synonym: "CGRP-R complex" EXACT []
is_a: GO:1903439 ! calcitonin family receptor complex
relationship: part_of GO:0005887 ! integral component of plasma membrane
created_by: bhm
creation_date: 2014-07-01T14:57:43Z

[Term]
id: GO:1990407
name: calcitonin gene-related peptide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with calcitonin gene-related peptide (CGRP)." [GOC:bhm, PMID:10882736]
comment: An example of this is CALCRL in human (Q16602) in PMID:10882736 (inferred from direct assay/mutant phenotype/etc.).
synonym: "calcitonin-gene-related peptide binding" EXACT []
synonym: "calcitonin-gene-related polypeptide binding" EXACT []
synonym: "CGRP polypeptide binding" EXACT []
is_a: GO:0097644 ! calcitonin family binding
created_by: bhm
creation_date: 2014-07-02T14:22:06Z

[Term]
id: GO:1990408
name: calcitonin gene-related peptide receptor signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by an extracellular calcitonin gene-related peptide (CGRP) combining with a calcitonin gene-related peptide receptor on the surface of the target cell. Calcitonin gene-related peptide receptors may form dimers, trimers or tetramers." [GOC:bhm, PMID:10882736]
comment: An example of a protein that could be annotated to this term is CALCRL in human (Q16602) in PMID:10882736.
synonym: "calcitonin-gene-related peptide receptor signaling pathway" EXACT []
synonym: "calcitonin-gene-related polypeptide receptor signaling pathway" EXACT []
synonym: "CGRP receptor signaling pathway" EXACT []
is_a: GO:0097646 ! calcitonin family receptor signaling pathway
created_by: bhm
creation_date: 2014-07-02T14:32:37Z

[Term]
id: GO:1990409
name: adrenomedullin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with adrenomedullin (AM)." [GOC:bhm, PMID:10882736]
comment: An example of a protein that could be annotated to this term is CALCRL in human (Q16602) in PMID:10882736.
synonym: "AM binding" EXACT []
is_a: GO:0097644 ! calcitonin family binding
created_by: bhm
creation_date: 2014-07-02T14:37:19Z

[Term]
id: GO:1990410
name: adrenomedullin receptor signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by an extracellular adrenomedullin combining with a dimeric adrenomedullin receptor on the surface of the target cell." [GOC:bhm, PMID:10882736]
comment: An example of a protein that could be annotated to this term is CALCRL in human (Q16602) in PMID:10882736.
synonym: "AM receptor signaling pathway" EXACT []
is_a: GO:0038042 ! dimeric G-protein coupled receptor signaling pathway
is_a: GO:0097646 ! calcitonin family receptor signaling pathway
created_by: bhm
creation_date: 2014-07-02T14:43:31Z

[Term]
id: GO:1990411
name: hercynylcysteine sulfoxide lyase activity (ergothioneine-forming)
namespace: molecular_function
def: "Catalysis of the reaction: hercynylcysteine sulfoxide + 2H+ = ergothioneine + pyruvate + ammonium." [PMID:24828577]
xref: MetaCyc:RXN-14428
xref: RHEA:42688
is_a: GO:0016846 ! carbon-sulfur lyase activity
relationship: part_of GO:0052699 ! ergothioneine biosynthetic process
created_by: mah
creation_date: 2014-07-02T15:45:43Z

[Term]
id: GO:1990412
name: hercynylselenocysteine lyase activity (selenoneine-forming)
namespace: molecular_function
def: "Catalysis of the reaction: hercynylselenocysteine + 2H+ = selenoneine + pyruvate + ammonium." [PMID:24828577]
xref: RHEA:42696
is_a: GO:0016846 ! carbon-sulfur lyase activity
created_by: mah
creation_date: 2014-07-02T15:51:07Z

[Term]
id: GO:1990413
name: eyespot apparatus
namespace: cellular_component
def: "A small pigmented organelle used in single-celled organisms to detect light." [Wikipedia:Eyespot_apparatus]
synonym: "eyespot" RELATED []
synonym: "stigma" RELATED []
is_a: GO:0043229 ! intracellular organelle
created_by: cjm
creation_date: 2014-07-03T21:26:24Z

[Term]
id: GO:1990414
name: replication-born double-strand break repair via sister chromatid exchange
namespace: biological_process
def: "The repair of a replication-born double-strand DNA break in which the DNA molecule is repaired using the homologous sequence of the sister chromatid which serves as a template to repair the breaks." [PMID:12820977, PMID:16888651\,GOC\:rb]
synonym: "replication-born DSB repair by SCE" EXACT []
is_a: GO:0000724 ! double-strand break repair via homologous recombination
created_by: rb
creation_date: 2014-07-10T21:20:34Z

[Term]
id: GO:1990415
name: Pex17p-Pex14p docking complex
namespace: cellular_component
def: "A protein complex involved in the peroxisomal import machinery. In S. cerevisiae, this complex contains the proteins Pex17p, Pex14p, Pex19, and Pex13p." [GOC:rb, PMID:12667447]
is_a: GO:0043234 ! protein complex
created_by: rb
creation_date: 2014-07-10T21:43:31Z

[Term]
id: GO:1990416
name: cellular response to brain-derived neurotrophic factor stimulus
namespace: biological_process
def: "A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brain-derived neurotrophic factor stimulus." [PMID:21958434]
synonym: "cellular response to BDNF stimulus" EXACT []
is_a: GO:1990090 ! cellular response to nerve growth factor stimulus
created_by: sl
creation_date: 2014-07-11T17:55:59Z

[Term]
id: GO:1990417
name: snoRNA release from pre-rRNA
namespace: biological_process
def: "The release of snoRNA from pre-rRNA." [PMID:16908538]
comment: An example of this process is yeast HAS1 from PMID:16908538, inferred from mutant phenotype assay.
xref: GOC:rb
is_a: GO:0006364 ! rRNA processing
is_a: GO:0016074 ! snoRNA metabolic process
created_by: rb
creation_date: 2014-07-11T21:43:27Z

[Term]
id: GO:1990418
name: response to insulin-like growth factor stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin-like growth factor stimulus." [PMID:21932665]
is_a: GO:0009725 ! response to hormone
created_by: sl
creation_date: 2014-07-14T22:47:59Z

[Term]
id: GO:1990419
name: obsolete response to elemental metal
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an elemental metal stimulus." [PMID:22688007]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
subset: termgenie_unvetted
synonym: "response to elemental metal" EXACT []
is_obsolete: true
created_by: sl
creation_date: 2014-07-15T20:17:56Z

[Term]
id: GO:1990420
name: establishment of septation initiation network asymmetry
namespace: biological_process
def: "The septation initiation signaling process by which the activity of the septation initiation network (SIN) is activated asymmetrically on the spindle pole bodies." [PMID:22786806]
synonym: "establishment of SIN asymmetry" EXACT [PMID:22786806]
is_a: GO:0031028 ! septation initiation signaling
created_by: al
creation_date: 2014-07-16T13:51:36Z

[Term]
id: GO:1990421
name: subtelomeric heterochromatin
namespace: cellular_component
def: "Heterochromatic regions of the chromosome found at the subtelomeric regions." [PMID:18761674, SO:0001997]
synonym: "sub-telomeric heterochromatin" EXACT []
is_a: GO:0000792 ! heterochromatin
created_by: mah
creation_date: 2014-07-18T13:32:59Z

[Term]
id: GO:1990422
name: glyoxalase (glycolic acid-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: glyoxal + H2O = glycolic acid. Catalysis occurs in the absence of a cofactor." [GOC:bf, GOC:PARL, PMID:22523093]
is_a: GO:0016836 ! hydro-lyase activity
relationship: part_of GO:0046295 ! glycolate biosynthetic process
relationship: part_of GO:1903190 ! glyoxal catabolic process
created_by: bf
creation_date: 2014-07-21T09:00:21Z

[Term]
id: GO:1990423
name: RZZ complex
namespace: cellular_component
def: "A kinetochore component required for both meiotic and mitotic spindle assembly checkpoints." [PMID:12686595, PMID:15922598, PMID:20462495]
comment: Example annotations for this term would be D. melanogaster mit(1)15 (Q9W4X9), rod and zwilch (Q9VA00).
synonym: "Rod-Zwilch-Zw10 complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000776 ! kinetochore
created_by: jl
creation_date: 2014-07-23T11:16:42Z

[Term]
id: GO:1990424
name: protein arginine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + a protein arginine = ADP + protein arginine phosphate." [GOC:imk, PMID:22517742]
comment: This reaction occurs in bacterial species e.g. Bacillus subtilis.
is_a: GO:0004672 ! protein kinase activity
created_by: jl
creation_date: 2014-07-23T13:35:56Z

[Term]
id: GO:1990425
name: ryanodine receptor complex
namespace: cellular_component
def: "A voltage-gated calcium-release channel complex of the sarcoplasmic or endoplasmic reticulum. It plays an important role in the excitation-contraction (E-C) coupling of muscle cells. RyR comprises a family of ryanodine receptors, widely expressed throughout the animal kingdom." [GOC:ame, IntAct:EBI-9632656, PMID:22822064]
comment: An example of this is RyR1 in rabbit (P11716) in PMID:2550460 (inferred from electron microscopy).
synonym: "RyR" RELATED []
is_a: GO:0005891 ! voltage-gated calcium channel complex
is_a: GO:0044432 ! endoplasmic reticulum part
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane
relationship: part_of GO:0033017 ! sarcoplasmic reticulum membrane
created_by: anm
creation_date: 2014-07-24T09:36:41Z

[Term]
id: GO:1990426
name: homologous recombination-dependent replication fork processing
namespace: biological_process
def: "Replication fork processing that includes recombination between DNA near the arrested fork and homologous sequences. Proteins involved in homologous recombination are required for replication restart." [GOC:mah, PMID:23093942]
synonym: "homologous recombination dependent replication fork recovery" RELATED [PMID:23093942]
is_a: GO:0031297 ! replication fork processing
relationship: has_part GO:0006312 ! mitotic recombination
created_by: mah
creation_date: 2014-07-24T09:42:54Z

[Term]
id: GO:1990427
name: stereocilia tip-link density
namespace: cellular_component
def: "An electron-dense plaque at either end of a stereocilia tip link that provides the anchor in the stereocilia membrane." [PMID:19447093, PMID:21709241]
is_a: GO:0044463 ! cell projection part
is_a: GO:0097458 ! neuron part
relationship: part_of GO:0002140 ! stereocilia tip link
created_by: sl
creation_date: 2014-07-25T20:55:36Z

[Term]
id: GO:1990428
name: miRNA transport
namespace: biological_process
def: "The directed movement of microRNA (miRNA) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GO:jl, PMID:24356509]
synonym: "microRNA transport" EXACT []
is_a: GO:0050658 ! RNA transport
created_by: jl
creation_date: 2014-07-29T14:03:46Z

[Term]
id: GO:1990429
name: peroxisomal importomer complex
namespace: cellular_component
def: "A protein complex responsible for transporting proteins into the peroxisomal matrix. An example of this complex is Pex14 found in S. cerevisae which has 9 core components and 12 transient interaction partners." [PMID:20154681, PMID:22375831]
synonym: "peroxisomal import pore" EXACT []
synonym: "peroxisomal protein import machinery" EXACT []
synonym: "Pex14 complex" NARROW []
is_a: GO:1990351 ! transporter complex
is_a: GO:1990415 ! Pex17p-Pex14p docking complex
created_by: jl
creation_date: 2014-07-29T14:45:28Z

[Term]
id: GO:1990430
name: extracellular matrix protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a protein that is part of an extracellular matrix." [PMID:22355679]
is_a: GO:0005515 ! protein binding
created_by: jl
creation_date: 2014-07-29T14:57:07Z

[Term]
id: GO:1990431
name: priRNA 3'-end processing
namespace: biological_process
def: "The process of forming the mature 3' end of a priRNA molecule." [PMID:24095277]
synonym: "primal small RNA 3'-end processing" EXACT []
synonym: "priRNA 3' end processing" EXACT []
is_a: GO:0043628 ! ncRNA 3'-end processing
created_by: jl
creation_date: 2014-07-29T15:34:19Z

[Term]
id: GO:1990432
name: siRNA 3'-end processing
namespace: biological_process
def: "The process of forming the mature 3' end of a siRNA molecule." [PMID:24095277]
synonym: "siRNA 3' end processing" EXACT []
synonym: "small interfering RNA 3'-end processing" EXACT []
is_a: GO:0043628 ! ncRNA 3'-end processing
created_by: jl
creation_date: 2014-07-29T15:38:38Z

[Term]
id: GO:1990433
name: CSL-Notch-Mastermind transcription factor complex
namespace: cellular_component
def: "A DNA binding transcription factor complex consisting of CSL and mastermind proteins in complex with the cleaved, intracellular domain of Notch. It is required for both repression and activation of Notch target genes." [GOC:bhm, GOC:dos, intAct:EBI-9636287, PMID:16530045]
synonym: "CSL-NotchIC-MASTERMIND complex" EXACT []
is_a: GO:0044798 ! nuclear transcription factor complex
relationship: part_of GO:0005634 ! nucleus
created_by: bhm
creation_date: 2014-07-30T14:41:43Z

[Term]
id: GO:1990434
name: lower tip-link density
namespace: cellular_component
def: "An electron-dense plaque at the lower end of a stereocilia tip link that provides the anchor in the stereocilia membrane at the tip of the stereocilium from which the tip link rises." [PMID:19447093]
synonym: "LTLD" EXACT []
is_a: GO:1990427 ! stereocilia tip-link density
created_by: sl
creation_date: 2014-07-30T16:34:34Z

[Term]
id: GO:1990435
name: upper tip-link density
namespace: cellular_component
def: "An electron-dense plaque at the upper end of a stereocilia tip link that provides the anchor in the stereocilia membrane on the side of the stereocilium where the tip link ends." [PMID:19447093]
synonym: "UTLD" EXACT []
is_a: GO:1990427 ! stereocilia tip-link density
created_by: sl
creation_date: 2014-07-30T16:36:32Z

[Term]
id: GO:1990436
name: obsolete MAPK cascade involved in oxidative stress signaling pathway
namespace: biological_process
def: "OBSOLETE. A series of molecular signals in which a MAP kinase cascade activated by oxidative stress relays one or more of the signals, MAP kinase cascades involve at least three protein kinase activities and culminate in the phosphorylation and activation of a MAP kinase. Just FYI in pombe the osmotic stress and oxidative stress MAPK cascade involve many of the same proteins, but the pathways are slightly different, therefore Im req this term." [PMID:10398679]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
subset: termgenie_unvetted
synonym: "MAPK cascade involved in oxidative stress signaling pathway" EXACT []
is_obsolete: true
created_by: al
creation_date: 2014-07-31T10:10:38Z

[Term]
id: GO:1990437
name: snRNA 2'-O-methylation
namespace: biological_process
def: "The posttranscriptional addition of a methyl group to the 2' oxygen atom of a nucleotide residue in an snRNA molecule." [PMID:11842100, PMID:9844635]
is_a: GO:0001510 ! RNA methylation
is_a: GO:0040031 ! snRNA modification
created_by: mah
creation_date: 2014-07-31T11:58:18Z

[Term]
id: GO:1990438
name: U6 2'-O-snRNA methylation
namespace: biological_process
def: "The posttranscriptional addition a methyl group to the 2'-oxygen atom of a nucleotide residue in an U6 snRNA molecule." [PMID:11842100, PMID:9844635]
is_a: GO:1990437 ! snRNA 2'-O-methylation
created_by: mah
creation_date: 2014-07-31T12:04:21Z

[Term]
id: GO:1990439
name: MAP kinase threonine phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: MAP kinase threonine phosphate + H2O = MAP kinase tyrosine + phosphate." [PMID:10398679]
is_a: GO:0004725 ! protein tyrosine phosphatase activity
is_a: GO:0033549 ! MAP kinase phosphatase activity
created_by: al
creation_date: 2014-07-31T12:21:04Z

[Term]
id: GO:1990440
name: positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an endoplasmic reticulum stress." [GOC:bf, GOC:PARL, PMID:21113145]
synonym: "activation of transcription from RNA polymerase II promoter in response to ER stress" EXACT [GOC:bf]
synonym: "ER stress-induced upregulation of transcription" BROAD [GOC:bf]
synonym: "stimulation of transcription from RNA polymerase II promoter in response to ER stress" EXACT [GOC:bf]
synonym: "up-regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress" EXACT [GOC:bf]
synonym: "up-regulation of transcription induced by ER stress" BROAD [GOC:bf, PMID:21113145]
synonym: "upregulation of Pol II transcription induced by ER stress" EXACT [GOC:bf, PMID:21113145]
synonym: "upregulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress" EXACT [GOC:bf]
is_a: GO:0034976 ! response to endoplasmic reticulum stress
is_a: GO:0036003 ! positive regulation of transcription from RNA polymerase II promoter in response to stress
created_by: bf
creation_date: 2014-07-31T12:56:54Z

[Term]
id: GO:1990441
name: negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an endoplasmic reticulum stress." [GOC:bf, GOC:PARL, PMID:21113145]
synonym: "down regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress" EXACT [GOC:bf]
synonym: "down-regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress" EXACT [GOC:bf]
synonym: "ER stress-induced negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:bf]
synonym: "inhibition of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress" EXACT [GOC:bf]
synonym: "negative regulation of transcription from RNA polymerase II promoter in response to ER stress" EXACT [GOC:bf]
synonym: "reduction of transcription from RNA polymerase II promoter under ER stress" EXACT [PMID:21113145]
synonym: "repression of transcription from RNA polymerase II promoter under ER stress" EXACT [PMID:21113145]
synonym: "suppression of transcription from RNA polymerase II promoter under ER stress" EXACT [PMID:21113145]
is_a: GO:0034976 ! response to endoplasmic reticulum stress
is_a: GO:0097201 ! negative regulation of transcription from RNA polymerase II promoter in response to stress
created_by: bf
creation_date: 2014-07-31T13:08:54Z

[Term]
id: GO:1990442
name: intrinsic apoptotic signaling pathway in response to nitrosative stress
namespace: biological_process
def: "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to nitrosative stress; a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions." [GOC:bf, GOC:PARL, PMID:23985028]
synonym: "nitrosative stress-induced apoptosis" RELATED [PMID:23985028]
synonym: "nitrosative stress-induced intrinsic apoptotic signaling pathway" EXACT [GOC:bf]
is_a: GO:0071500 ! cellular response to nitrosative stress
is_a: GO:0097193 ! intrinsic apoptotic signaling pathway
created_by: bf
creation_date: 2014-07-31T14:28:16Z

[Term]
id: GO:1990443
name: peptidyl-threonine autophosphorylation
namespace: biological_process
def: "The phosphorylation by a protein of one or more of its own threonine amino acid residues, or a threonine residue on an identical protein." [PMID:7803855]
is_a: GO:0018107 ! peptidyl-threonine phosphorylation
is_a: GO:0046777 ! protein autophosphorylation
created_by: al
creation_date: 2014-08-02T15:08:41Z

[Term]
id: GO:1990444
name: F-box domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an F-box domain of a protein." [GOC:bf, GOC:PARL, InterPro:IPR001810, PMID:12628165]
is_a: GO:0019904 ! protein domain specific binding
created_by: bf
creation_date: 2014-08-05T13:45:14Z

[Term]
id: GO:1990445
name: obsolete Multiciliate cell differentiation
namespace: biological_process
def: "OBSOLETE. The process in which a relatively unspecialized cell acquires features of a multiciliated cell, a specialized epithelial cell type that extends anywhere from 150 to 200 motile cilia per cell in order to produce a vigorous fluid flow critical to human health in several organ systems." [PMID:22231168, PMID:24934224]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
subset: termgenie_unvetted
synonym: "Multiciliate cell differentiation" EXACT []
is_obsolete: true
created_by: sp
creation_date: 2014-08-05T14:31:28Z

[Term]
id: GO:1990446
name: U1 snRNP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any part of a U1 small nuclear ribonucleoprotein particle." [PMID:14713954]
is_a: GO:0070990 ! snRNP binding
created_by: mah
creation_date: 2014-08-06T09:29:44Z

[Term]
id: GO:1990447
name: U2 snRNP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any part of a U2 small nuclear ribonucleoprotein particle." [PMID:14713954]
is_a: GO:0070990 ! snRNP binding
created_by: mah
creation_date: 2014-08-06T09:33:38Z

[Term]
id: GO:1990448
name: exon-exon junction complex binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an exon-exon junction complex, a protein complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay." [GOC:sart, PMID:24967911]
synonym: "EJC binding" EXACT []
is_a: GO:0032403 ! protein complex binding
created_by: sart
creation_date: 2014-08-06T10:02:46Z

[Term]
id: GO:1990449
name: obsolete amylin receptor
namespace: cellular_component
def: "OBSOLETE. A G-protein coupled signalling receptor complex consisting of the calcitonin receptor and a receptor activity-modifying protein (RAMP). Amylin is produced in beta-islet cells of the pancreas. It is implicated in selective inhibition of insulin-stimulated glucose utilization and glycogen deposition in muscle, gastric emptying, gastric acid secretion, postprandial glucagon secretion and food intake and aids weight loss." [GOC:bhm, IntAct:EBI-9008682, IntAct:EBI-9685417, IntAct:EBI-9685439, PMID:10871269]
comment: An example of this is CALCR in human (P30988) in PMID:10871269.
subset: termgenie_unvetted
synonym: "AMY1 receptor" NARROW []
synonym: "AMY2 receptor" NARROW []
synonym: "AMY3 receptor" NARROW []
synonym: "amylin receptor" EXACT []
synonym: "CALCR-RAMP1 receptor" NARROW []
synonym: "CALCR-RAMP2 receptor" NARROW []
synonym: "CALCR-RAMP3 receptor" NARROW []
is_obsolete: true
created_by: bhm
creation_date: 2014-08-06T10:21:37Z

[Term]
id: GO:1990450
name: linear polyubiquitin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a linear polymer of ubiquitin. Linear ubiquitin polymers are formed by linking the amino-terminal methionine (M1) of one ubiquitin molecule to the carboxy-terminal glycine (G76) of the next." [GOC:bf, GOC:PARL, PMID:23453807]
synonym: "M1-linked ubiquitin chain binding" EXACT [PMID:23453807]
is_a: GO:0031593 ! polyubiquitin binding
created_by: bf
creation_date: 2014-08-06T11:10:26Z

[Term]
id: GO:1990451
name: cellular stress response to acidic pH
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in the homeostasis of organismal or cellular pH (with pH < 7). pH is a measure of the acidity or basicity of an aqueous solution." [GOC:BHF, GOC:go_curators, GOC:rl, PMID:10615049]
comment: An example of this is NOX1 in human (Q9Y5S8) in PMID:10615049.
synonym: "cellular stress response to acidity" BROAD []
is_a: GO:0033554 ! cellular response to stress
is_a: GO:0071468 ! cellular response to acidic pH
created_by: jl
creation_date: 2014-08-06T14:06:58Z

[Term]
id: GO:1990452
name: Parkin-FBXW7-Cul1 ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex containing Parkin (PARK2), the F-box protein FBXW7 (also called SEL-10) and a cullin from the Cul1 subfamily; substrate specificity is conferred by the F-box protein." [GOC:bf, GOC:PARL, PMID:12628165]
synonym: "PARK2-FBXW7-Cul1 complex" EXACT [GOC:bf]
synonym: "Parkin-FBXW7-Cul1 protein complex" EXACT [GOC:bf]
synonym: "Parkin-HSel-10-Cullin-1 complex" NARROW [PMID:12628165]
synonym: "Parkin/Cul1/F-box protein complex" EXACT [GOC:bf]
is_a: GO:0000151 ! ubiquitin ligase complex
created_by: bf
creation_date: 2014-08-07T14:25:49Z

[Term]
id: GO:1990453
name: nucleosome disassembly/reassembly complex
namespace: cellular_component
def: "A protein complex involved in the disassembly and subsequent reassembly of nucleosomes. It associates with the coding region of transcriptionally active genes where it interacts with the RNA polymerase II and affects its processivity during co-transcriptional RNA processing and maturation. It exists as a functionally independent part of the NuA4 complex." [GOC:bhm, IntAct:EBI-9682603, PMID:24843044]
comment: An example of this is EAF7 in Saccharomyces cerevisiae (P53911) in PMID:24843044 (inferred from direct assay).
synonym: "eaf5/7/3 complex" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0005634 ! nucleus
created_by: bhm
creation_date: 2014-08-08T15:18:30Z

[Term]
id: GO:1990454
name: L-type voltage-gated calcium channel complex
namespace: cellular_component
def: "A type of voltage-dependent calcium channel responsible for excitation-contraction coupling of skeletal, smooth, and cardiac muscle. 'L' stands for 'long-lasting' referring to the length of activation." [GOC:ame, PMID:12946355]
comment: Examples of this are CACNA1S, CACNA2D1, CACNB1, CACNG1 in rabbit (UniProt symbol P07293, P13806, P19517 and P19518) in PMID:12946355 (inferred from direct assay).
synonym: "cardiac muscle L-type voltage-gated calcium channel complex" NARROW []
synonym: "skeletal muscle L-type voltage-gated calcium channel complex" NARROW []
is_a: GO:0005891 ! voltage-gated calcium channel complex
relationship: part_of GO:0030315 ! T-tubule
created_by: anm
creation_date: 2014-08-12T17:22:10Z

[Term]
id: GO:1990455
name: PTEN phosphatase complex
namespace: cellular_component
def: "A phospholipid phosphatase complex that catalyses the hydrolysis of the second messenger PtdIns (3,4,5)P3. Will also dephosphorylate PtdIns(3,4)P2, PtdIns3P, and Ins(1,3,4,5)P4. Dimerization is critical for its lipid phosphatase function." [GOC:bhm, IntAct:EBI-9637198, IntAct:EBI-9637224, PMID:24766807]
comment: An example of this is PTEN in human (P60484) in PMID:24766807 (inferred from direct assay).
synonym: "phosphatase and tensin homolog" EXACT []
synonym: "phosphatase and tensin homolog deleted on chromosome ten homodimer" EXACT []
synonym: "phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN homodimer" EXACT []
is_a: GO:0044464 ! cell part
is_a: GO:1904144 ! phosphatidylinositol phosphate phosphatase complex
relationship: part_of GO:0005623 ! cell
created_by: bhm
creation_date: 2014-08-13T10:21:20Z

[Term]
id: GO:1990456
name: mitochondrion-ER tethering
namespace: biological_process
def: "The attachment of the mitochondrion to specific sites on the endoplasmic reticulum, which may facilitate exchange of metabolites between the organelles." [PMID:19556461]
synonym: "mitochondrion-endoplasmic reticulum attachment" EXACT []
synonym: "mitochondrion-endoplasmic reticulum tethering" EXACT []
synonym: "mitochondrion-ER attachment" EXACT []
is_a: GO:0016043 ! cellular component organization
is_a: GO:0051659 ! maintenance of mitochondrion location
created_by: mcc
creation_date: 2014-08-14T13:32:30Z

[Term]
id: GO:1990457
name: pexophagosome
namespace: cellular_component
def: "A membrane-bounded intracellular vesicle involved in the degradation of peroxisome by macropexophagy." [PMID:22536249]
is_a: GO:0045335 ! phagocytic vesicle
created_by: dhl
creation_date: 2014-08-15T18:51:53Z

[Term]
id: GO:1990458
name: lipooligosaccharide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with lipooligosaccharide. Lipooligosaccharides (LOSs) are the major glycolipids expressed on mucosal Gram-negative bacteria." [GOC:hjd, PMID:8894399]
comment: ChEBI distinguishes an oligosaccharide from a polysaccharide as the latter being anything of length 10 or greater.
synonym: "endotoxin binding" RELATED []
synonym: "LOS binding" RELATED []
is_a: GO:0097367 ! carbohydrate derivative binding
created_by: hjd
creation_date: 2014-08-15T19:58:08Z

[Term]
id: GO:1990459
name: transferrin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the transferrin receptor." [PMID:9819414, PMID:pm]
is_a: GO:0005102 ! receptor binding
created_by: tb
creation_date: 2014-08-18T20:14:24Z

[Term]
id: GO:1990460
name: leptin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the leptin receptor." [GOC:pm, PMID:22405007]
is_a: GO:0005102 ! receptor binding
created_by: tb
creation_date: 2014-08-18T20:17:43Z

[Term]
id: GO:1990461
name: detoxification of iron ion
namespace: biological_process
def: "Any process that reduces or removes the toxicity of iron ion. These include transport of iron away from sensitive areas and to compartments or complexes whose purpose is sequestration of iron ion." [GOC:sart, PMID:23064556]
is_a: GO:0061687 ! detoxification of inorganic compound
relationship: part_of GO:0010039 ! response to iron ion
created_by: sart
creation_date: 2014-08-19T10:12:46Z

[Term]
id: GO:1990462
name: omegasome
namespace: cellular_component
def: "Omega-shaped (as in the Greek capital letter) intracellular membrane-bounded organelle enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum. Omegasomes are the first step of the formation of autophagosomes via the pre-autophagosomal structures." [GOC:autophagy, GOC:mf, PMID:18725538, PMID:24591649]
is_a: GO:0043231 ! intracellular membrane-bounded organelle
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0012505 ! endomembrane system
created_by: pr
creation_date: 2014-08-19T12:26:40Z

[Term]
id: GO:1990463
name: lateral cortical node
namespace: cellular_component
def: "A protein complex that is anchored at the cortical face of the plasma membrane, and contains proteins involved in regulating cell cycle progression. In Schizosaccharomyces pombe, lateral cortical nodes are several megadaltons in size, and contain Slf1, which anchors the complex at the membrane, and the methyltransferase Skb1 in stoichiometric quantities, and may contain other proteins." [GOC:mah, PMID:25009287]
synonym: "Skb1-containing cortical node" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044448 ! cell cortex part
relationship: part_of GO:0097575 ! lateral cell cortex
created_by: pr
creation_date: 2014-08-20T09:04:45Z

[Term]
id: GO:1990464
name: D-2-hydroxyacid dehydrogenase (quinone) activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-2-hydroxyacid + a quinone = 2-oxoacid + a quinol." [EC:1.1.5.10, GOC:am, PMID:3013300, PMID:4582730]
comment: (R)-lactate, (R)-malate and meso-tartrate are good substrates. Ubiquinone-1 and the dye 2,6-dichloroindophenol can act as acceptors; NAD+ and NADP+ are not acceptors.
synonym: "(R)-2-hydroxy acid dehydrogenase activity" RELATED [EC:1.1.5.10]
synonym: "(R)-2-hydroxy-acid:(acceptor) 2-oxidoreductase activity" RELATED [EC:1.1.5.10]
synonym: "(R)-2-hydroxyacid:quinone oxidoreductase activity" EXACT [EC:1.1.5.10]
synonym: "D-lactate dehydrogenase (quinone) activity" RELATED [GOC:am]
synonym: "D-lactate dehydrogenase activity" RELATED [EC:1.1.5.10]
synonym: "D-lactate:quinone oxidoreductase activity" RELATED [GOC:am]
is_a: GO:0016901 ! oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor
created_by: pr
creation_date: 2014-08-22T10:13:42Z

[Term]
id: GO:1990465
name: aldehyde oxygenase (deformylating) activity
namespace: molecular_function
def: "Catalysis of the reaction a long-chain aldehyde + O(2) + 2 NADPH = an alkane + formate + H(2)O + 2 NADP(+)." [GOC:mengo_curators, PMID:22947199]
xref: EC:4.1.99.5
is_a: GO:0016830 ! carbon-carbon lyase activity
created_by: tt
creation_date: 2014-08-25T15:16:43Z

[Term]
id: GO:1990466
name: protein autosumoylation
namespace: biological_process
def: "The sumoylation by a protein of one or more of its own amino acid residues, or residues on an identical protein." [PMID:21518767, PMID:23443663]
synonym: "protein auto-sumoylation" EXACT []
synonym: "protein self-sumoylation" EXACT []
is_a: GO:0016925 ! protein sumoylation
created_by: se
creation_date: 2014-08-25T22:37:21Z

[Term]
id: GO:1990467
name: NuA3a histone acetyltransferase complex
namespace: cellular_component
def: "A NuA3 complex that catalyzes the acetylation of Histone H3. In S. cerevisiae, this complex consists of Eaf6p, Nto1p, Sas3p, Taf14p, Yng1p and associates with H3K4me3 using Yng1p." [GOC:rb, PMID:25104842]
is_a: GO:0033100 ! NuA3 histone acetyltransferase complex
created_by: rb
creation_date: 2014-08-25T23:07:45Z

[Term]
id: GO:1990468
name: NuA3b histone acetyltransferase complex
namespace: cellular_component
def: "A NuA3 complex that catalyzes the acetylation of Histone H3. In S. cerevisiae, this complex consists of Eaf6p, Nto1p, Sas3p, Taf14p, Pdp3 and associates with H3K4me3 via Pdp3p." [GOC:rb, PMID:25104842]
is_a: GO:0033100 ! NuA3 histone acetyltransferase complex
created_by: rb
creation_date: 2014-08-25T23:13:37Z

[Term]
id: GO:1990469
name: Rhino-Deadlock-Cutoff Complex
namespace: cellular_component
def: "Protein complex found in Drosophila consisting of the gene products of cuff, del and rhi. It regulates the licensing of transcription of dual-strand PIWI interacting RNA (piRNA) source loci by binding to dual-strand-cluster chromatin, probably via the H3K9me3-binding activity of Rhi. Rhi binding brings the putative termination cofactor Cuff in close proximity to the nascent piRNA precursor transcript which it appears to protect from degradation." [GOC:bhm, IntAct:EBI-9694217, PMID:24906153]
comment: An example of this is cuff in Drosophila melanogaster (Q9V629) in PMID:24906153.
synonym: "RDC complex" EXACT []
synonym: "rhi-del-cuff complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0043073 ! germ cell nucleus
created_by: bhm
creation_date: 2014-08-29T14:08:37Z

[Term]
id: GO:1990470
name: piRNA cluster binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with piRNA clusters, double-stranded DNA regions that give rise to PIWI-interacting RNAs (piRNAs)." [GOC:bhm, PMID:24906153]
comment: An example of this is rhi in Drosophila melanogaster (Q7JXA8) in PMID:24906153 (inferred from direct assay).
is_a: GO:1990837 ! sequence-specific double-stranded DNA binding
created_by: bhm
creation_date: 2014-08-29T14:23:38Z

[Term]
id: GO:1990471
name: piRNA uni-strand cluster binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with uni-strand piRNA clusters, double-stranded DNA regions that give rise to PIWI-interacting RNAs (piRNAs) that map predominantly to only one strand and exhibit hallmarks of canonical Pol II transcription. Uni-strand piRNA clusters are found in many taxa." [GOC:bhm, PMID:24906153]
is_a: GO:1990470 ! piRNA cluster binding
created_by: bhm
creation_date: 2014-08-29T14:37:35Z

[Term]
id: GO:1990472
name: piRNA dual-strand cluster binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with dual-strand piRNA clusters, double-stranded DNA regions that give rise to PIWI-interacting RNAs (piRNAs) where piRNAs originate from both DNA strands via noncanonical transcription." [GOC:bhm, PMID:24906153]
comment: An example of this is rhi in Drosophila melanogaster (Q7JXA8) in PMID:24906153 (inferred from direct assay).
is_a: GO:1990470 ! piRNA cluster binding
created_by: bhm
creation_date: 2014-08-29T14:50:54Z

[Term]
id: GO:1990473
name: ciliary targeting signal binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a ciliary targeting sequence, a specific peptide sequence that acts as a signal to localize a membrane protein to the ciliary membrane." [GOC:krc, PMID:18256283, PMID:19575670, PMID:20603001, PMID:20697559]
synonym: "CTS binding" EXACT []
is_a: GO:0005048 ! signal sequence binding
created_by: pr
creation_date: 2014-09-02T08:22:03Z

[Term]
id: GO:1990474
name: synaptic vesicle, readily releasable pool
namespace: cellular_component
def: "A synaptic vesicle belonging to the pool of vesicles that are the first to be released as a result of chemical or electrical stimulation e.g. by an action potential, have the highest presynaptic membrane fusion probability and correspond to about 1% of the total number of synaptic vesicles at a resting terminal bouton." [GOC:pad, PMID:22745285]
synonym: "readily releasable pool of synaptic vesicles" EXACT []
synonym: "RRP" RELATED []
is_a: GO:0008021 ! synaptic vesicle
is_a: GO:0033267 ! axon part
relationship: part_of GO:0043195 ! terminal bouton
created_by: pr
creation_date: 2014-09-02T09:02:41Z

[Term]
id: GO:1990475
name: synaptic vesicle, recycling pool
namespace: cellular_component
def: "A synaptic vesicle belonging to the pool that repopulate vacancies within the readily releasable pool (RRP) of synaptic vesicles, and require more significant stimuli than the RRP in order to release neurotransmitter; about 10-15% of the total number of synaptic vesicles at a resting terminal bouton are in this state." [GOC:pad, PMID:22745285]
synonym: "recycling pool of synaptic vesicles" EXACT []
is_a: GO:0008021 ! synaptic vesicle
relationship: part_of GO:0098794 ! postsynapse
created_by: pr
creation_date: 2014-09-02T09:08:22Z

[Term]
id: GO:1990476
name: synaptic vesicle, resting pool
namespace: cellular_component
def: "A synaptic vesicle belonging to the pool that remain unreleased even after prolonged stimulation  causes a saturating degree of vesicular turnover.  50-80% of the total number of synaptic vesicles at a resting terminal bouton are in this pool." [GOC:pad, PMID:22745285]
subset: goslim_synapse
synonym: "reserve pool of synaptic vesicles" EXACT [PMID:15611727]
synonym: "resting pool of synaptic vesicles" EXACT []
is_a: GO:0008021 ! synaptic vesicle
is_a: GO:0033267 ! axon part
relationship: part_of GO:0043195 ! terminal bouton
created_by: pr
creation_date: 2014-09-02T09:12:37Z

[Term]
id: GO:1990477
name: NURS complex
namespace: cellular_component
def: "The nuclear RNA silencing (NURS) complex is a protein complex formed by Red1, Mtl1, Red5, Rmn1, Iss10/Pir1, and Ars2/Pir2 that regulates RNA degradation and histone H3 lysine 9 methylation. It is likely related to the human CBCN complex." [PMID:24713849]
is_a: GO:0043234 ! protein complex
relationship: has_part GO:1990345 ! MTREC complex
created_by: al
creation_date: 2014-09-04T14:46:54Z

[Term]
id: GO:1990478
name: response to ultrasound
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultrasonic stimulus." [PMID:20950932]
is_a: GO:0009612 ! response to mechanical stimulus
created_by: sl
creation_date: 2014-09-09T22:11:32Z

[Term]
id: GO:1990479
name: obsolete response to lipoic acid
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoic acid stimulus." [PMID:23232760]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
subset: termgenie_unvetted
synonym: "response to 5-(1,2-dithiolan-3-yl)pentanoic acid" EXACT []
is_obsolete: true
created_by: sl
creation_date: 2014-09-09T22:20:41Z

[Term]
id: GO:1990480
name: obsolete geranyl diphosphate synthase
namespace: molecular_function
def: "OBSOLETE. Catalyzes the condensation of dimethylallyl diphosphate and isopentenyl diphosphate to geranyl diphosphate, the key precursor of monoterpene biosynthesis." [GOC:mengo_curators, PMID:10557273]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
xref: PMID:10557273
is_obsolete: true
replaced_by: GO:0004161
created_by: tt
creation_date: 2014-09-10T01:14:17Z

[Term]
id: GO:1990481
name: mRNA pseudouridine synthesis
namespace: biological_process
def: "The intramolecular conversion of uridine to pseudouridine in an mRNA molecule." [PMID:25192136]
synonym: "mRNA pseudouridylation" EXACT []
is_a: GO:0001522 ! pseudouridine synthesis
is_a: GO:0016556 ! mRNA modification
created_by: mcc
creation_date: 2014-09-12T15:13:39Z

[Term]
id: GO:1990482
name: sphingolipid alpha-glucuronosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucuronate + inositol phosphorylceramide (IPC) = UDP + GlcA-IPC." [GOC:tb, PMID:25122154]
synonym: "inositol phosphorylceramide glucuronosyltransferase activity" RELATED []
is_a: GO:0008194 ! UDP-glycosyltransferase activity
created_by: tb
creation_date: 2014-09-12T22:10:09Z

[Term]
id: GO:1990483
name: Clr6 histone deacetylase complex I''
namespace: cellular_component
def: "A histone deacetylase complex involved in chromatin organization. In Schizosaccharomyces pombe this complex consists of Clr6, Nts1, Mug165, and Png3." [PMID:25002536]
is_a: GO:0000118 ! histone deacetylase complex
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000790 ! nuclear chromatin
created_by: al
creation_date: 2014-09-16T10:40:51Z

[Term]
id: GO:1990484
name: aerobic lactate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lactate (2-hydroxypropanoic acid) in the presence of oxygen." [GOC:mengo_curators, PMID:8941775]
synonym: "aerobic lactic acid catabolic process" RELATED []
is_a: GO:1903457 ! lactate catabolic process
created_by: tt
creation_date: 2014-09-20T05:42:51Z

[Term]
id: GO:1990485
name: anaerobic lactate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lactate (2-hydroxypropanoic acid) in the absence of oxygen." [GOC:mengo_curators, PMID:11133436]
synonym: "anaerobic lactic acid catabolic process" RELATED []
is_a: GO:1903457 ! lactate catabolic process
created_by: tt
creation_date: 2014-09-20T16:48:06Z

[Term]
id: GO:1990486
name: anaerobic fatty acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a fatty acid in the absence of oxygen. A fatty acid is any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mengo_curators, PMID:17329794]
synonym: "anaerobic fatty acid degradation" EXACT []
is_a: GO:0009062 ! fatty acid catabolic process
created_by: tt
creation_date: 2014-09-20T17:25:48Z

[Term]
id: GO:1990487
name: anaerobic lignin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lignin in the absence of oxygen. Lignin is a class of polymers of phenylpropanoid units." [DOI:10.1039/C3EE40932E, GOC:mengo_curators]
synonym: "anaerobic lignin degradation" EXACT []
is_a: GO:0046274 ! lignin catabolic process
created_by: tt
creation_date: 2014-09-20T17:35:09Z

[Term]
id: GO:1990488
name: anaerobic cellulose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, in absence of oxygen." [GOC:mengo_curators, PMID:8561466]
synonym: "anaerobic cellulose degradation" EXACT []
is_a: GO:0030245 ! cellulose catabolic process
created_by: tt
creation_date: 2014-09-20T17:43:59Z

[Term]
id: GO:1990489
name: anaerobic pectin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues, in the absence of oxygen." [GOC:mengo_curators, PMID:23079077]
synonym: "anaerobic pectin degradation" EXACT []
is_a: GO:0045490 ! pectin catabolic process
created_by: tt
creation_date: 2014-09-20T18:09:53Z

[Term]
id: GO:1990490
name: archaeal proton-transporting A-type ATPase complex
namespace: cellular_component
def: "A large proton-transporting two-sector ATPase protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane and is found in Archaea." [GOC:mengo_curators, PMID:15473999, PMID:24650628]
synonym: "A-type ATPase protein complex" BROAD []
synonym: "archaeal A-type ATPase protein complex" BROAD []
is_a: GO:0016469 ! proton-transporting two-sector ATPase complex
created_by: tt
creation_date: 2014-09-20T19:13:55Z

[Term]
id: GO:1990491
name: methane biosynthetic process from methanol and hydrogen
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of methane from methanol and hydrogen." [GOC:mengo_curators, PMID:16347126]
synonym: "methane biosynthesis from methanol and hydrogen" EXACT []
synonym: "methanogenesis from methanol and hydrogen" EXACT []
is_a: GO:0019387 ! methanogenesis, from methanol
is_a: GO:1902421 ! hydrogen metabolic process
created_by: tt
creation_date: 2014-09-21T01:08:40Z

[Term]
id: GO:1990492
name: mitotic cell cycle checkpoint inhibiting CAR assembly
namespace: biological_process
def: "A Mad2-dependent mitotic cell cycle checkpoint which delays cytokinetic actinomycin ring assembly if there is a delay in early M-phase." [PMID:12186944]
synonym: "Mad2-dependent mitotic cell cycle checkpoint" RELATED [GOC:dph, GOC:vw]
synonym: "mitotic cell cycle checkpoint inhibiting cytokinetic actomyosin ring assembly" EXACT []
is_a: GO:0007093 ! mitotic cell cycle checkpoint
is_a: GO:1903500 ! negative regulation of mitotic actomyosin contractile ring assembly
created_by: vw
creation_date: 2014-09-23T12:43:22Z

[Term]
id: GO:1990493
name: obsolete cyclin H-CDK7 complex
namespace: cellular_component
def: "OBSOLETE. A protein complex consisting of cyclin H and cyclin-dependent kinase 7 (CDK7). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [PMID:9857180]
comment: This term was made obsolete because it was added in error.
synonym: "cyclin H-CDK7 complex" EXACT []
is_obsolete: true
created_by: al
creation_date: 2014-09-24T10:08:44Z

[Term]
id: GO:1990494
name: obsolete regulation of mitotic cytokinesis, actomyosin contractile ring assembly
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of mitotic cytokinesis, actomyosin contractile ring assembly." [PMID:18256290]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
subset: termgenie_unvetted
synonym: "regulation of mitotic cytokinesis, actomyosin contractile ring assembly" EXACT []
is_obsolete: true
created_by: al
creation_date: 2014-09-25T09:04:55Z

[Term]
id: GO:1990495
name: obsolete actin filament organization involved in mitotic cytokinetic actomyosin contractile ring assembly
namespace: biological_process
def: "OBSOLETE. An actin filament organization process that contributes to actomyosin contractile ring assembly during mitotic cytokinesis." [PMID:8834798]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
subset: termgenie_unvetted
synonym: "actin filament organization involved in mitotic cytokinetic actomyosin contractile ring assembly" EXACT []
is_obsolete: true
created_by: al
creation_date: 2014-09-25T09:19:27Z

[Term]
id: GO:1990496
name: obsolete regulation of actin filament organization involved in mitotic cytokinetic actomyosin contractile ring assembly
namespace: biological_process
def: "OBSOLETE. An actin filament organization process that contributes to regulation of actomyosin contractile ring assembly during mitotic cytokinesis." [PMID:24798735]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
subset: termgenie_unvetted
synonym: "regulation of actin filament organization involved in mitotic cytokinetic actomyosin contractile ring assembly" EXACT []
is_obsolete: true
created_by: al
creation_date: 2014-09-25T09:21:57Z

[Term]
id: GO:1990497
name: regulation of cytoplasmic translation in response to stress
namespace: biological_process
def: "Modulation of the frequency, rate or extent of cytoplasmic translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:vw, PMID:16278445]
is_a: GO:0043555 ! regulation of translation in response to stress
is_a: GO:2000765 ! regulation of cytoplasmic translation
created_by: vw
creation_date: 2014-09-26T11:11:29Z

[Term]
id: GO:1990498
name: mitotic spindle microtubule
namespace: cellular_component
def: "Any microtubule that is part of a mitotic spindle; anchored at one spindle pole." [GOC:vw]
is_a: GO:0005876 ! spindle microtubule
relationship: part_of GO:0072686 ! mitotic spindle
created_by: vw
creation_date: 2014-09-26T13:34:40Z

[Term]
id: GO:1990499
name: raps-insc complex
namespace: cellular_component
def: "Protein complex required for the asymmetric division of neuroblasts in Drosophila. Coordinates asymmetric localization of cell fate determinants with orientation of the mitotic spindle resulting in different daughter cells upon division. Localizes at the apical cortex of the neuroblast: Raps maintains, but does not initiate, Insc apically, while Insc segregates Raps asymmetrically. Complex appears to be conserved in mammals (composed of INSC and GPSM1 or GPSM2)." [GOC:bhm, IntAct:EBI-9674411, PMID:22171003]
comment: An example of this is Insc in drome (Q9W2R4) in PMID:22171003 (inferred from physical interaction).
synonym: "partner of inscuteable-inscuteable complex" EXACT []
synonym: "Rapsynoid-Inscuteable complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044448 ! cell cortex part
relationship: part_of GO:0045179 ! apical cortex
created_by: bhm
creation_date: 2014-09-30T09:22:18Z

[Term]
id: GO:1990500
name: eif4e-cup complex
namespace: cellular_component
def: "A protein complex that causes translational repression in Drosophila. Prevents assembly of ribosomes at the mRNA by interfacing with a sequence-specific RNA-binding protein leading to recruitment of the CCR4 complex and consequently, reduction of the mRNA's poly(A) tail length. The complex is also required for dorso-ventral pattern formation in the embryo." [GOC:bhm, IntAct:EBI-9674930, PMID:14723848]
comment: An example of this is Eif4e in drome (P48598) in PMID:14723848 (inferred from physical interaction).
synonym: "eukaryotic translation initiation factor 4E-cup complex" EXACT []
is_a: GO:0044422 ! organelle part
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:1903502 ! translation repressor complex
relationship: part_of GO:0000932 ! cytoplasmic mRNA processing body
created_by: bhm
creation_date: 2014-09-30T12:31:49Z

[Term]
id: GO:1990501
name: exon-exon junction subcomplex mago-y14
namespace: cellular_component
def: "Component of the core exon-exon-junction complex (EJC). Fairly conserved in eukaryotes; in Drosophila, consists of the Mago and Y14 (tsunagi) gene products. Important for coupling nuclear and cytoplasmic events in gene expression. Inhibits the ATPase activity of eIF4AIII (Q9VHS8) to ensure a stable association of the EJC core with the mRNA." [GOC:bhm, IntAct:EBI-9549962, PMID:12730685]
comment: An example of this is Mago in drome (P49028) in PMID:12730685 (inferred from direct assay).
synonym: "mago-y14 complex" RELATED []
synonym: "MGN-RBM8A complex" EXACT []
is_a: GO:0035145 ! exon-exon junction complex
is_a: GO:1903503 ! ATPase inhibitor complex
created_by: bhm
creation_date: 2014-09-30T14:05:28Z

[Term]
id: GO:1990502
name: dense core granule maturation
namespace: biological_process
def: "Steps required to transform a dense core granule generated at the trans-Golgi network into a fully formed and transmissible dense core granule. Dense core granule maturation proceeds through clathrin-mediated membrane remodeling events and is essential for efficient processing of cargo within dense core granules as well as for removing factors that might otherwise interfere with dense core granule trafficking and exocytosis." [GOC:kmv, PMID:22654674]
synonym: "dense core vesicle maturation" EXACT []
is_a: GO:0016050 ! vesicle organization
created_by: kmv
creation_date: 2014-09-30T20:35:11Z

[Term]
id: GO:1990503
name: dendritic lamellar body
namespace: cellular_component
def: "A specialized secretory organelle found in neurons and associated with the formation of dendrodendritic gap junctions." [PMID:7869120]
synonym: "DLB" EXACT []
is_a: GO:0042599 ! lamellar body
is_a: GO:0044463 ! cell projection part
is_a: GO:0097458 ! neuron part
relationship: part_of GO:0030425 ! dendrite
created_by: sl
creation_date: 2014-09-30T20:47:28Z

[Term]
id: GO:1990504
name: dense core granule exocytosis
namespace: biological_process
def: "The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense core granule by fusion of the granule with the plasma membrane of a cell in response to increased cytosolic calcium levels." [GOC:kmv, PMID:17553987, PMID:24653208]
synonym: "dense core vesicle exocytosis" EXACT []
is_a: GO:0017156 ! calcium ion regulated exocytosis
created_by: kmv
creation_date: 2014-09-30T21:05:50Z

[Term]
id: GO:1990505
name: mitotic DNA replication maintenance of fidelity
namespace: biological_process
alt_id: GO:1990510
def: "Any maintenance of fidelity that is involved in mitotic cell cycle DNA replication." [PMID:19185548]
synonym: "maintenance of fidelity involved in mitotic cell cycle DNA replication" EXACT []
synonym: "maintenance of fidelity involved in mitotic DNA replication" EXACT []
synonym: "mitotic DNA replication maintenance of fidelity" EXACT []
is_a: GO:1902298 ! cell cycle DNA replication maintenance of fidelity
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:1902298 ! cell cycle DNA replication maintenance of fidelity
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:1902969 ! mitotic DNA replication
created_by: al
creation_date: 2014-10-01T14:09:05Z

[Term]
id: GO:1990506
name: mitotic DNA-dependent DNA replication
namespace: biological_process
def: "A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands during the mitotic cell cycle." [PMID:16120966]
is_a: GO:1902969 ! mitotic DNA replication
relationship: part_of GO:0000278 ! mitotic cell cycle
created_by: al
creation_date: 2014-10-01T14:13:23Z

[Term]
id: GO:1990507
name: ATP-independent chaperone mediated protein folding
namespace: biological_process
def: "The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone, and independent of ATP hydrolysis." [GOC:rb, PMID:25242142]
is_a: GO:0061077 ! chaperone-mediated protein folding
created_by: rb
creation_date: 2014-10-01T23:55:05Z

[Term]
id: GO:1990508
name: CKM complex
namespace: cellular_component
def: "Cyclin-dependent kinase complex which reversibly associates with the Mediator complex. In Saccharomyces cerevisiae it consists of SSN2, SSN3, SSN8 and SRB8." [GOC:bhm, IntAct:EBI-2640924, PMID:12200444]
comment: An example of this is SSN2 in Saccharomyces cerevisiae (P38931) in PMID:12200444 (inferred from physical interaction).
synonym: "CDK8 kinase module" EXACT []
synonym: "SRB8-SRB11 complex" EXACT []
synonym: "SRB8/9/10/11 complex" EXACT []
is_a: GO:0019908 ! nuclear cyclin-dependent protein kinase holoenzyme complex
relationship: part_of GO:0005634 ! nucleus
created_by: bhm
creation_date: 2014-10-02T10:05:58Z

[Term]
id: GO:1990509
name: PYM-mago-Y14 complex
namespace: cellular_component
def: "Protein complex involved in the disassembly of Mago-Y14 from the spliced mRNA during first round of translation, independently of the translational machinery. Conserved from fission yeast to humans." [GOC:bhm, IntAct:EBI-9634190, PMID:14968132]
comment: An example of this is wibg in Drosophila melanogaster (P82804) in PMID:14968132 (inferred from physical interaction).
synonym: "PYM-mago-RNA-binding protein 8A complex" EXACT []
synonym: "wibg-mago-tsu complex" EXACT []
is_a: GO:0043234 ! protein complex
relationship: has_part GO:1990501 ! exon-exon junction subcomplex mago-y14
created_by: bhm
creation_date: 2014-10-03T12:52:01Z

[Term]
id: GO:1990511
name: piRNA biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism." [PMID:24696457]
synonym: "Piwi-associated RNA biosynthetic process" EXACT []
xref: GOC:kmv
is_a: GO:0034587 ! piRNA metabolic process
created_by: kmv
creation_date: 2014-10-07T13:47:32Z

[Term]
id: GO:1990512
name: Cry-Per complex
namespace: cellular_component
def: "Nuclear transcriptional repressor complex that is capable of negatively regulating CLOCK-BMAL-dependent transactivation of genes in a delayed negative feedback manner which generates circadian rhythms." [GOC:bhm, IntAct:EBI-9693126, IntAct:EBI-9693260, IntAct:EBI-9694282, IntAct:EBI-9695878, IntAct:EBI-9695921, IntAct:EBI-9695942, IntAct:EBI-9696219, IntAct:EBI-9696270, IntAct:EBI-9696293, IntAct:EBI-9696310, IntAct:EBI-9696328, IntAct:EBI-9696345, PMID:24855952]
comment: An example of this is Cry1 in mouse (P97784) in PMID:24855952 (inferred from physical interaction).
is_a: GO:0090568 ! nuclear transcriptional repressor complex
relationship: part_of GO:0005634 ! nucleus
created_by: bhm
creation_date: 2014-10-08T10:53:07Z

[Term]
id: GO:1990513
name: CLOCK-BMAL transcription complex
namespace: cellular_component
def: "Transcription factor complex which interacts with E-box regulatory elements in target genes, including Period (Per1, Per2, Per3) and Cryptochrome (Cry1, Cry2), to activate their transcription during the daytime. The CRY-PER complexes inhibit CLOCK-BMAL1-driven transcription in a negative feedback loop to generate circadian rhythms." [GOC:bhm, IntAct:EBI-9696362, IntAct:EBI-9696901, IntAct:EBI-9696921, IntAct:EBI-9696951, PMID:23229515]
comment: An example of this is CLOCK in human (O15516) in PMID:23229515 (inferred from physical interaction).
synonym: "CLOCK/BMAL complex" EXACT []
is_a: GO:0044798 ! nuclear transcription factor complex
relationship: part_of GO:0005634 ! nucleus
created_by: bhm
creation_date: 2014-10-08T13:10:24Z

[Term]
id: GO:1990514
name: 5' transitive RNA interference
namespace: biological_process
def: "An RNA interference where the silencing signal spreads 5' along the target mRNA, outside of the initial target sequence. Typically involves the formation of secondary siRNAs formed when the initial mRNA target sequence functions as a template for 5' to 3' synthesis of new dsRNA." [GOC:pf, PMID:24369430]
is_a: GO:0036453 ! transitive RNA interference
created_by: jl
creation_date: 2014-10-09T15:29:31Z

[Term]
id: GO:1990515
name: 3' transitive RNA interference
namespace: biological_process
def: "An RNA interference where the silencing signal spreads 3' along the target mRNA, outside of the initial target sequence. Typically involves the formation of secondary siRNAs formed when the initial mRNA target sequence functions as a template for 5' to 3' synthesis of new dsRNA." [GOC:pf, PMID:24369430]
is_a: GO:0036453 ! transitive RNA interference
created_by: jl
creation_date: 2014-10-09T15:31:01Z

[Term]
id: GO:1990516
name: ribonucleotide excision repair
namespace: biological_process
def: "The pathway by which a ribonucleotide is removed from DNA and replaced by a deoxyribonucleotide. The ribonucleotide is incised by RNase H2, and further excised by an endonuclease. The resulting 1 nt gap is then repaired by DNA polymerase and DNA ligase." [PMID:12475934, PMID:22864116]
is_a: GO:0070716 ! mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication
created_by: al
creation_date: 2014-10-14T12:24:37Z

[Term]
id: GO:1990517
name: obsolete protein localization to photoreceptor outer segment
namespace: biological_process
def: "OBSOLETE. A process in which a protein is transported to, or maintained in, a location within a photoreceptor outer segment, which is a portion of a modified sensory cilium." [GOC:krc, PMID:20212494]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
subset: termgenie_unvetted
is_obsolete: true
created_by: krc
creation_date: 2014-10-14T14:01:34Z

[Term]
id: GO:1990518
name: single-stranded DNA-dependent ATP-dependent 3'-5' DNA helicase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of the DNA helix in the direction 3' to 5'." [PMID:25165823]
is_a: GO:0017116 ! single-stranded DNA-dependent ATP-dependent DNA helicase activity
is_a: GO:0043140 ! ATP-dependent 3'-5' DNA helicase activity
created_by: al
creation_date: 2014-10-22T10:17:40Z

[Term]
id: GO:1990519
name: mitochondrial pyrimidine nucleotide import
namespace: biological_process
def: "The directed movement of a pyrimidine nucleotide across the mitochondrial outer membrane into the mitochondria." [PMID:16194150]
is_a: GO:0006864 ! pyrimidine nucleotide transport
is_a: GO:0072531 ! pyrimidine-containing compound transmembrane transport
is_a: GO:1901679 ! nucleotide transmembrane transport
is_a: GO:1990542 ! mitochondrial transmembrane transport
created_by: vw
creation_date: 2014-10-22T10:20:23Z

[Term]
id: GO:1990520
name: separase-securin complex
namespace: cellular_component
def: "A protein complex that includes separase and securin as components and that inhibits chromosome separation at mitosis." [GOC:dos, GOC:vw, PMID:8978688]
synonym: "Cut1-2 complex" EXACT [PMID:8978688]
is_a: GO:0043234 ! protein complex
created_by: vw
creation_date: 2014-10-23T10:34:52Z

[Term]
id: GO:1990521
name: m7G(5')pppN diphosphatase activator activity
namespace: molecular_function
def: "Binds to and increases the activity of m7G(5')pppN diphosphatase." [PMID:22323607]
is_a: GO:0008047 ! enzyme activator activity
relationship: positively_regulates GO:0050072 ! m7G(5')pppN diphosphatase activity
created_by: vw
creation_date: 2014-10-23T11:20:56Z

[Term]
id: GO:1990522
name: tail spike morphogenesis
namespace: biological_process
def: "The process in which the nematode tail spike is generated and organized. An example of this process is seen in C. elegans, where the tapered tail spike is formed during embryogenesis by a filamentous process that passes posteriorly through hyp10, the tail ventral hypodermis; the filamentous process is formed by a binucleate cell, the tail-spike cell, that subsequently undergoes programmed cell death." [GOC:kmv, PMID:17329362, PMID:6684600]
xref: WBbt:0006979
xref: WBbt:0008072
is_a: GO:0009653 ! anatomical structure morphogenesis
created_by: jl
creation_date: 2014-10-23T15:20:15Z

[Term]
id: GO:1990523
name: bone regeneration
namespace: biological_process
def: "The regrowth of bone following its loss or destruction." [PMID:25257467]
is_a: GO:0042246 ! tissue regeneration
created_by: sl
creation_date: 2014-10-30T15:47:39Z

[Term]
id: GO:1990524
name: INA complex
namespace: cellular_component
def: "A protein complex located in the inner membrane of mitochondria that is involved in the assembly of the peripheral (or stator) stalk of the mitochondrial proton-transporting ATP synthase (also known as the F1F0 ATP synthase). In budding yeast, this complex includes Ina22p and Ina17p." [GOC:rn, PMID:24942160]
synonym: "INAC" EXACT []
is_a: GO:0098800 ! inner mitochondrial membrane protein complex
relationship: part_of GO:0031304 ! intrinsic component of mitochondrial inner membrane
created_by: jl
creation_date: 2014-11-03T16:03:39Z

[Term]
id: GO:1990525
name: BIR domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a Baculovirus Inhibitor of apoptosis protein Repeat (BIR) domain." [GOC:ha, InterPro:IPR001370]
comment: An example of this is the Drosophila reaper gene in PMID:21886178.
synonym: "Baculovirus Inhibitor of apoptosis protein Repeat domain binding" EXACT []
is_a: GO:0019904 ! protein domain specific binding
created_by: jl
creation_date: 2014-11-04T12:36:56Z

[Term]
id: GO:1990526
name: Ste12p-Dig1p-Dig2p complex
namespace: cellular_component
def: "A multiprotein complex that is involved in the transcription regulation of mating genes in the yeast S. cerevisiae." [GOC:rb, PMID:16782869]
is_a: GO:0043234 ! protein complex
created_by: rb
creation_date: 2014-11-05T22:49:32Z

[Term]
id: GO:1990527
name: Tec1p-Ste12p-Dig1p complex
namespace: cellular_component
def: "A multiprotein complex that is involved in the transcription regulation of mating genes in the yeast S. cerevisiae." [GOC:rb, PMID:16782869]
is_a: GO:0043234 ! protein complex
created_by: rb
creation_date: 2014-11-05T22:55:17Z

[Term]
id: GO:1990528
name: Rvs161p-Rvs167p complex
namespace: cellular_component
def: "A protein complex that is involved in endocytosis in the yeast S. cerevisiae." [GOC:rb, PMID:20610658]
is_a: GO:0043234 ! protein complex
created_by: rb
creation_date: 2014-11-05T23:11:32Z

[Term]
id: GO:1990529
name: glycosylphosphatidylinositol-mannosyltransferase I complex
namespace: cellular_component
def: "A protein complex that is involved in the transfer of the four mannoses in the GPI-anchor precursor. In yeast S. cerevisiae this complex consists of Pbn1p and Gpi14p and in rat this complex consists of PIG-X and PIG-M." [GOC:dph, GOC:rb, PMID:15635094]
synonym: "GPI-MT-I complex" RELATED []
is_a: GO:0031501 ! mannosyltransferase complex
is_a: GO:0044432 ! endoplasmic reticulum part
relationship: part_of GO:0005783 ! endoplasmic reticulum
created_by: rb
creation_date: 2014-11-06T01:02:31Z

[Term]
id: GO:1990530
name: Cdc50p-Drs2p complex
namespace: cellular_component
def: "A protein complex that assembles on the ER membrane and is essential for the ER exit of the Cdc50p-Drs2p complex." [GOC:rb, PMID:15090616]
is_a: GO:0043234 ! protein complex
created_by: rb
creation_date: 2014-11-06T01:29:31Z

[Term]
id: GO:1990531
name: Lem3p-Dnf1p complex
namespace: cellular_component
def: "A protein complex that functions as a phospholipid-translocating P-Type ATPase." [GOC:dph, GOC:rb, PMID:15090616]
is_a: GO:1904949 ! ATPase complex
is_a: GO:1990351 ! transporter complex
created_by: rb
creation_date: 2014-11-06T22:33:25Z

[Term]
id: GO:1990532
name: stress response to nickel ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a nickel ion stimulus." [PMID:25330323]
synonym: "response to nickel ion stress" EXACT []
synonym: "response to nickel toxicity" EXACT []
synonym: "stress response to nickel" EXACT []
xref: GOC:kmv
is_a: GO:0097501 ! stress response to metal ion
created_by: kmv
creation_date: 2014-11-07T18:35:31Z

[Term]
id: GO:1990533
name: Dom34-Hbs1 complex
namespace: cellular_component
def: "A protein complex consisting of one subunit known as Dom34 or Pelota that has similarity to translation termination factor eRF1, and another subunit, Hbs1, that is a GTPase with similarity to translation termination factor eRF3. The Dom34-Hbs1 complex has a role in cotranslational mRNA quality control by promoting ribosomal subunit dissociation and peptidyl-tRNA release when translation is stalled, facilitating no-go decay and nonstop decay." [GOC:mcc, PMID:20890290, PMID:21102444, PMID:21448132, PMID:22503425]
synonym: "Dom34:Hbs1 complex" EXACT []
is_a: GO:0043234 ! protein complex
created_by: mcc
creation_date: 2014-11-07T20:49:03Z

[Term]
id: GO:1990534
name: thermospermine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-methyl-5'-thioadenosine + thermospermine + H+ = S-adenosyl 3-(methylthio)propylamine + spermidine." [PMID:24906355]
is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor
created_by: tb
creation_date: 2014-11-13T00:41:59Z

[Term]
id: GO:1990535
name: neuron projection maintenance
namespace: biological_process
def: "The organization process that preserves a neuron projection in a stable functional or structural state. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [PMID:25359212]
synonym: "neurite maintenance" NARROW []
synonym: "neuron process maintenance" EXACT []
synonym: "neuron protrusion maintenance" EXACT []
synonym: "neuronal cell projection maintenance" EXACT []
xref: GOC:kmv
is_a: GO:0043954 ! cellular component maintenance
created_by: kmv
creation_date: 2014-11-13T22:24:05Z

[Term]
id: GO:1990536
name: phosphoenolpyruvate transmembrane import into Golgi lumen
namespace: biological_process
def: "The directed movement of phosphoenolpyruvate into the Golgi lumen across the Golgi membrane." [PMID:25195688]
is_a: GO:0089722 ! phosphoenolpyruvate transmembrane transport
created_by: vw
creation_date: 2014-11-14T10:17:01Z

[Term]
id: GO:1990537
name: mitotic spindle polar microtubule
namespace: cellular_component
def: "Any of the mitotic spindle microtubules that come from each pole and overlap at the spindle midzone." [PMID:16079915]
is_a: GO:0005827 ! polar microtubule
is_a: GO:1990498 ! mitotic spindle microtubule
created_by: vw
creation_date: 2014-11-14T15:32:38Z

[Term]
id: GO:1990538
name: xylan O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + a xylan= CoA + an acetylated xylan." [PMID:25141999]
is_a: GO:0016413 ! O-acetyltransferase activity
created_by: tb
creation_date: 2014-11-18T20:02:51Z

[Term]
id: GO:1990539
name: fructose import across plasma membrane
namespace: biological_process
def: "The directed movement of fructose substance from outside of a cell, across the plasma membrane and into the cytosol." [PMID:10735857]
is_a: GO:0032445 ! fructose import
is_a: GO:0035428 ! hexose transmembrane transport
is_a: GO:0098704 ! carbohydrate import across plasma membrane
created_by: vw
creation_date: 2014-11-19T10:57:17Z

[Term]
id: GO:1990540
name: mitochondrial manganese ion transmembrane transport
namespace: biological_process
def: "A process in which a manganese ion is transported from one side of a mitochondrial membrane to the other by means of some agent such as a transporter or pore." [PMID:12890866]
is_a: GO:0071421 ! manganese ion transmembrane transport
is_a: GO:1990542 ! mitochondrial transmembrane transport
created_by: vw
creation_date: 2014-11-19T11:03:09Z

[Term]
id: GO:1990541
name: mitochondrial citrate transmembrane transport
namespace: biological_process
def: "The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:20371607]
is_a: GO:0006843 ! mitochondrial citrate transport
is_a: GO:1990546 ! mitochondrial tricarboxylic acid transmembrane transport
created_by: vw
creation_date: 2014-11-19T11:08:45Z

[Term]
id: GO:1990542
name: mitochondrial transmembrane transport
namespace: biological_process
def: "The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:20533899]
is_a: GO:0006839 ! mitochondrial transport
is_a: GO:0055085 ! transmembrane transport
created_by: vw
creation_date: 2014-11-19T11:19:21Z

[Term]
id: GO:1990543
name: mitochondrial S-adenosyl-L-methionine transmembrane transport
namespace: biological_process
def: "The directed movement of S-adenosyl-L-methionine from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:14609944]
is_a: GO:0015859 ! intracellular nucleoside transport
is_a: GO:1901962 ! S-adenosyl-L-methionine transmembrane transport
is_a: GO:1990542 ! mitochondrial transmembrane transport
created_by: vw
creation_date: 2014-11-19T11:26:27Z

[Term]
id: GO:1990544
name: mitochondrial ATP transmembrane transport
namespace: biological_process
def: "The directed movement of ATP from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:18485069]
is_a: GO:0015859 ! intracellular nucleoside transport
is_a: GO:0015860 ! purine nucleoside transmembrane transport
is_a: GO:0015867 ! ATP transport
is_a: GO:0098656 ! anion transmembrane transport
is_a: GO:1901679 ! nucleotide transmembrane transport
is_a: GO:1990542 ! mitochondrial transmembrane transport
created_by: vw
creation_date: 2014-11-19T11:43:33Z

[Term]
id: GO:1990545
name: mitochondrial thiamine pyrophosphate transmembrane transport
namespace: biological_process
def: "The directed movement of thiamine pyrophosphate from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:12411483]
is_a: GO:0030974 ! thiamine pyrophosphate transport
is_a: GO:0072531 ! pyrimidine-containing compound transmembrane transport
is_a: GO:0098655 ! cation transmembrane transport
is_a: GO:0098656 ! anion transmembrane transport
is_a: GO:1990542 ! mitochondrial transmembrane transport
created_by: vw
creation_date: 2014-11-19T11:47:15Z

[Term]
id: GO:1990546
name: mitochondrial tricarboxylic acid transmembrane transport
namespace: biological_process
def: "The directed movement of a tricarboxylic acid from one side of a membrane to the other into, out of or within a mitochondrion." [GOC:vw]
is_a: GO:0035674 ! tricarboxylic acid transmembrane transport
is_a: GO:1990542 ! mitochondrial transmembrane transport
created_by: vw
creation_date: 2014-11-19T12:00:14Z

[Term]
id: GO:1990547
name: mitochondrial phosphate ion transmembrane transport
namespace: biological_process
def: "The directed movement of phosphate ion from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:9099701]
is_a: GO:0035435 ! phosphate ion transmembrane transport
is_a: GO:1990542 ! mitochondrial transmembrane transport
created_by: vw
creation_date: 2014-11-19T11:50:19Z

[Term]
id: GO:1990548
name: mitochondrial FAD transmembrane transport
namespace: biological_process
def: "The directed movement of FAD from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:14555654]
is_a: GO:0035350 ! FAD transmembrane transport
is_a: GO:1990542 ! mitochondrial transmembrane transport
created_by: vw
creation_date: 2014-11-19T12:04:35Z

[Term]
id: GO:1990549
name: mitochondrial NAD transmembrane transport
namespace: biological_process
def: "The directed movement of NAD from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:16291748]
is_a: GO:0035352 ! NAD transmembrane transport
is_a: GO:1990542 ! mitochondrial transmembrane transport
created_by: vw
creation_date: 2014-11-19T12:09:51Z

[Term]
id: GO:1990550
name: mitochondrial alpha-ketoglutarate transmembrane transport
namespace: biological_process
alt_id: GO:1990552
def: "The directed movement of alpha-ketoglutarate from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:11013234, PMID:20371607]
synonym: "mitochondrial 2-oxoglutarate transmembrane transport" EXACT []
is_a: GO:0015742 ! alpha-ketoglutarate transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport
is_a: GO:1990542 ! mitochondrial transmembrane transport
created_by: vw
creation_date: 2014-11-19T12:11:59Z

[Term]
id: GO:1990551
name: mitochondrial 2-oxoadipate transmembrane transport
namespace: biological_process
def: "The directed movement of 2-oxoadipate from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:11013234]
is_a: GO:0006835 ! dicarboxylic acid transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport
is_a: GO:1990542 ! mitochondrial transmembrane transport
created_by: vw
creation_date: 2014-11-19T12:25:48Z

[Term]
id: GO:1990553
name: mitochondrial 5'-adenylyl sulfate transmembrane transport
namespace: biological_process
def: "The directed movement of 5'-adenylyl sulfate from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:24296033]
is_a: GO:0015859 ! intracellular nucleoside transport
is_a: GO:1902558 ! 5'-adenylyl sulfate transmembrane transport
is_a: GO:1990542 ! mitochondrial transmembrane transport
created_by: vw
creation_date: 2014-11-19T12:32:01Z

[Term]
id: GO:1990554
name: mitochondrial 3'-phospho-5'-adenylyl sulfate transmembrane transport
namespace: biological_process
def: "The directed movement of 3'-phospho-5'-adenylyl sulfate from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:24296033]
is_a: GO:0015859 ! intracellular nucleoside transport
is_a: GO:1902559 ! 3'-phospho-5'-adenylyl sulfate transmembrane transport
is_a: GO:1990542 ! mitochondrial transmembrane transport
created_by: vw
creation_date: 2014-11-19T12:39:22Z

[Term]
id: GO:1990555
name: mitochondrial oxaloacetate transmembrane transport
namespace: biological_process
def: "The directed movement of oxaloacetate from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:10428783]
is_a: GO:1902356 ! oxaloacetate(2-) transmembrane transport
is_a: GO:1990542 ! mitochondrial transmembrane transport
created_by: vw
creation_date: 2014-11-19T12:45:37Z

[Term]
id: GO:1990556
name: mitochondrial isopropylmalate transmembrane transport
namespace: biological_process
def: "The directed movement of isopropylmalate from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:10428783]
is_a: GO:1902357 ! 2-isopropylmalate(2-) transmembrane transport
is_a: GO:1990542 ! mitochondrial transmembrane transport
created_by: vw
creation_date: 2014-11-19T12:47:11Z

[Term]
id: GO:1990557
name: mitochondrial sulfate transmembrane transport
namespace: biological_process
def: "The directed movement of sulfate from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:10428783]
is_a: GO:1902358 ! sulfate transmembrane transport
is_a: GO:1990542 ! mitochondrial transmembrane transport
created_by: vw
creation_date: 2014-11-19T12:49:35Z

[Term]
id: GO:1990558
name: mitochondrial malonate(1-) transmembrane transport
namespace: biological_process
def: "The directed movement of malonate(1-) from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:10428783]
is_a: GO:1901553 ! malonic acid transmembrane transport
is_a: GO:1990542 ! mitochondrial transmembrane transport
created_by: vw
creation_date: 2014-11-19T12:52:43Z

[Term]
id: GO:1990559
name: mitochondrial coenzyme A transmembrane transport
namespace: biological_process
def: "The directed movement of coenzyme A from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:11158296]
is_a: GO:0015859 ! intracellular nucleoside transport
is_a: GO:0035349 ! coenzyme A transmembrane transport
is_a: GO:1990542 ! mitochondrial transmembrane transport
created_by: vw
creation_date: 2014-11-19T12:58:26Z

[Term]
id: GO:1990560
name: obsolete DNA methyltransferase binding
namespace: molecular_function
def: "OBSOLETE. Interacting selectively and non-covalently with a DNA methyltransferase." [PMID:22880885]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
subset: termgenie_unvetted
synonym: "DNA methyltransferase binding" EXACT []
is_obsolete: true
created_by: sl
creation_date: 2014-11-19T16:30:28Z

[Term]
id: GO:1990561
name: regulation of transcription from RNA polymerase II promoter in response to copper ion starvation
namespace: biological_process
def: "Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is deprived of copper ions." [GOC:al, PMID:10593913]
is_a: GO:0035874 ! cellular response to copper ion starvation
is_a: GO:0043618 ! regulation of transcription from RNA polymerase II promoter in response to stress
created_by: al
creation_date: 2014-11-25T14:21:55Z

[Term]
id: GO:1990562
name: syndecan-syntenin-ALIX complex
namespace: cellular_component
def: "An exosome complex that is assembled in the multivesicular body (MVB) membrane and chaperoned to the exosome by the ESCRT-III machinery." [GOC:bhm, IntAct:EBI-9985210, IntAct:EBI-9985797, PMID:22660413]
comment: An example of this is SCD1 in human (UniProt symbol P18827) in PMID:22660413 (inferred from physical interaction).
synonym: "exosome complex" BROAD []
is_a: GO:1990563 ! extracellular exosome complex
relationship: part_of GO:0070062 ! extracellular exosome
created_by: bhm
creation_date: 2014-11-25T16:30:47Z

[Term]
id: GO:1990563
name: extracellular exosome complex
namespace: cellular_component
def: "A protein complex that is wholly or partially contained within the lumen or membrane of the extracellular vesicular exosome." [GOC:bhm, IntAct:EBI-9985210, IntAct:EBI-9985797, PMID:22660413]
comment: An example of this is SCD1 in human (UniProt symbol P18827) in PMID:22660413 (inferred from physical interaction).
synonym: "exosome complex" EXACT []
synonym: "extracellular vesicular exosome complex" EXACT [GOC:vesicles]
is_a: GO:0043234 ! protein complex
is_a: GO:0044421 ! extracellular region part
is_a: GO:0044422 ! organelle part
relationship: part_of GO:0070062 ! extracellular exosome
created_by: bhm
creation_date: 2014-11-25T16:35:53Z

[Term]
id: GO:1990564
name: protein polyufmylation
namespace: biological_process
def: "Covalent attachment of the ubiquitin-like protein UFM1 to a protein, forming an UFM1 chain." [PMID:25219498]
is_a: GO:0071569 ! protein ufmylation
created_by: jl
creation_date: 2014-11-26T14:15:36Z

[Term]
id: GO:1990565
name: HSP90-CDC37 chaperone complex
namespace: cellular_component
def: "A protein complex involved in stress-induced mitophagy (mitochondrial degradation). In mammals it consists of heat shock protein HSP90 and its co-chaperone CDC37. Experimental evidence suggests that the complex enables the autophosphorylation of ULK1. Phosphorylated ULK1 in turn phosphorylates ATG13 which is an essential step in mitophagy. HSP90-CDC37 binding prevents rapid ubiquitin-dependent proteosomal degradation of its targets." [GOC:bhm, GOC:pad, GOC:PARL, IntAct:EBI-9990131, IntAct:EBI-9990540, PMID:21855797, PMID:22939624]
comment: An example of this is HSP90AB1 in human (UniProt symbol P08238) in PMID:21855797 (inferred from direct assay).
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0005737 ! cytoplasm
created_by: bhm
creation_date: 2014-11-26T14:22:51Z

[Term]
id: GO:1990566
name: I(KACh) inward rectifier potassium channel complex
namespace: cellular_component
def: "An inward rectifier potassium channel complex expressed in cardiac muscle, specifically the sinoatrial node and atria, where it controls the heart rate, via regulation by G-protein-coupled receptor signalling. In mammals it is composed of GIRK1 (or Kir3.1) and GIRK4 (or Kir3.4) subunits." [GOC:ame, IntAct:EBI-9975539, PMID:9765280]
comment: Examples of this are KCNJ3 and KCNJ5 in human (Uniprot symbols P48549 and P48544) in PMID:9765280 inferred from orthology sequence evidence.
synonym: "GIRK1-GIRK4 G protein-coupled atrial inward rectifier potassium channel complex" RELATED []
synonym: "Kir3.1-Kir3.4 G protein-coupled atrial inward rectifier potassium channel complex" RELATED []
synonym: "muscarinic potassium channel complex" RELATED []
is_a: GO:1902937 ! inward rectifier potassium channel complex
created_by: ame
creation_date: 2014-11-26T15:16:14Z

[Term]
id: GO:1990567
name: DPS complex
namespace: cellular_component
def: "A protein serine/threonine phosphatase complex that in S. pombe consists of the proteins Dis2, Ppn1, and Swd22." [PMID:24945319]
is_a: GO:0008287 ! protein serine/threonine phosphatase complex
created_by: al
creation_date: 2014-11-27T09:56:18Z

[Term]
id: GO:1990568
name: obsolete MIS18 complex
namespace: cellular_component
def: "OBSOLETE. A centromere complex assembly protein that is required for the deposition of CENP-A on the centromere. The Mis18 complex localizes to centromeres just prior to the pre-nucleosomal HJURP/CENP-A/H4 complex and is absolutely required for the CENP-A-specific chaperone, Holliday junction recognition protein (HJURP) to reach the centromeres. Plk1 phosphorylation activates Mis18 complex recruitment to the centromeres during G1. CDK phosphorylation of MISBP1 during G2 and mitosis, prior to the metaphase-to-anaphase transition, negatively regulates complex assembly." [GOC:bhm, IntAct:EBI-9872194, IntAct:EBI-9873644, PMID:25036634]
comment: An example of this is MIS18A in human (Q9NYP9) in PMID:25036634 (inferred from physical interaction).
subset: termgenie_unvetted
synonym: "MIS18 complex" EXACT []
is_obsolete: true
created_by: bhm
creation_date: 2014-11-27T10:52:20Z

[Term]
id: GO:1990569
name: UDP-N-acetylglucosamine transmembrane transport
namespace: biological_process
def: "The directed movement of UDP-N-acetylglucosamine across a membrane." [PMID:10788474]
is_a: GO:0015788 ! UDP-N-acetylglucosamine transport
is_a: GO:0090481 ! pyrimidine nucleotide-sugar transmembrane transport
is_a: GO:0098656 ! anion transmembrane transport
created_by: vw
creation_date: 2014-11-27T11:56:35Z

[Term]
id: GO:1990570
name: GDP-mannose transmembrane transport
namespace: biological_process
def: "The directed movement of GDP-mannose across a membrane." [PMID:9395539]
is_a: GO:0015784 ! GDP-mannose transport
is_a: GO:0090480 ! purine nucleotide-sugar transmembrane transport
created_by: vw
creation_date: 2014-11-27T12:05:09Z

[Term]
id: GO:1990571
name: meiotic centromere clustering
namespace: biological_process
def: "The process by which centromeres/kinetochores become localized to clusters during a meiotic nuclear division. For example, in Schizosaccharomyces pombe, centromeres are located in one or two clusters away from the spindle pole body during meiosis." [PMID:10366596, PMID:9009280]
synonym: "centromere clustering during meiosis" EXACT []
is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle
is_a: GO:0098653 ! centromere clustering
is_a: GO:1902580 ! single-organism cellular localization
relationship: part_of GO:0045132 ! meiotic chromosome segregation
created_by: mah
creation_date: 2014-12-02T11:25:37Z

[Term]
id: GO:1990572
name: TERT-RMRP complex
namespace: cellular_component
def: "A ribonucleoprotein complex that has RNA-directed RNA polymerase (RdRP) activity, and is composed of telomerase reverse transcriptase (TERT) and the non-coding RNA component of mitochondrial RNA processing endoribonuclease (RMRP)." [GOC:bf, GOC:BHF, GOC:nc, PMID:19701182]
synonym: "telomerase reverse transcriptase:RMRP RNA complex" EXACT [PMID:19701182]
is_a: GO:0030529 ! intracellular ribonucleoprotein complex
is_a: GO:0031379 ! RNA-directed RNA polymerase complex
created_by: bf
creation_date: 2014-12-02T11:29:12Z

[Term]
id: GO:1990573
name: potassium ion import across plasma membrane
namespace: biological_process
def: "The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol." [PMID:9139127]
is_a: GO:0098739 ! import across plasma membrane
relationship: part_of GO:0010107 ! potassium ion import
created_by: vw
creation_date: 2014-12-04T09:48:12Z

[Term]
id: GO:1990574
name: meiotic spindle astral microtubule
namespace: cellular_component
def: "Any of the meiotic spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell." [PMID:10366596]
is_a: GO:0000235 ! astral microtubule
intersection_of: GO:0000235 ! astral microtubule
intersection_of: part_of GO:0072687 ! meiotic spindle
relationship: part_of GO:0072687 ! meiotic spindle
created_by: vw
creation_date: 2014-12-04T09:55:09Z

[Term]
id: GO:1990575
name: mitochondrial L-ornithine transmembrane transport
namespace: biological_process
def: "The directed movement of L-ornithine from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:9237680]
synonym: "mitochondrial ornithine transmembrane transport" BROAD []
is_a: GO:0000066 ! mitochondrial ornithine transport
is_a: GO:1903352 ! L-ornithine transmembrane transport
is_a: GO:1990542 ! mitochondrial transmembrane transport
created_by: mah
creation_date: 2014-12-05T11:29:49Z

[Term]
id: GO:1990576
name: G-protein coupled glucose receptor activity
namespace: molecular_function
def: "Combining with an extracellular glucose molecule and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [PMID:15667320]
is_a: GO:0004930 ! G-protein coupled receptor activity
created_by: al
creation_date: 2014-12-08T03:15:12Z

[Term]
id: GO:1990577
name: C-terminal protein demethylation
namespace: biological_process
def: "The removal of a methyl group from the C-terminal amino acid of a protein." [PMID:11060018]
is_a: GO:0006482 ! protein demethylation
created_by: mcc
creation_date: 2014-12-08T20:55:17Z

[Term]
id: GO:1990578
name: perinuclear endoplasmic reticulum membrane
namespace: cellular_component
def: "The membrane of the perinuclear endoplasmic reticulum, which is the portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus." [PMID:25454947]
synonym: "perinuclear ER membrane" EXACT []
is_a: GO:0016020 ! membrane
is_a: GO:0044425 ! membrane part
is_a: GO:0044432 ! endoplasmic reticulum part
intersection_of: GO:0016020 ! membrane
intersection_of: part_of GO:0097038 ! perinuclear endoplasmic reticulum
relationship: part_of GO:0042175 ! nuclear outer membrane-endoplasmic reticulum membrane network
relationship: part_of GO:0097038 ! perinuclear endoplasmic reticulum
created_by: mcc
creation_date: 2014-12-09T01:13:01Z

[Term]
id: GO:1990579
name: peptidyl-serine trans-autophosphorylation
namespace: biological_process
def: "The phosphorylation of a peptidyl-serine to form peptidyl-O-phospho-L-serine on an identical protein. For example, phosphorylation by the other kinase within a homodimer." [GOC:bf, GOC:PARL, PMID:21317875]
synonym: "serine autophosphorylation in trans" EXACT [PMID:21317875]
synonym: "serine transautophosphorylation" EXACT [PMID:21317875]
is_a: GO:0036289 ! peptidyl-serine autophosphorylation
is_a: GO:0036290 ! protein trans-autophosphorylation
created_by: bf
creation_date: 2014-12-09T09:20:08Z

[Term]
id: GO:1990580
name: regulation of cytoplasmic translational termination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cytoplasmic translational termination." [PMID:11570975]
is_a: GO:0006449 ! regulation of translational termination
is_a: GO:2000765 ! regulation of cytoplasmic translation
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: regulates GO:0002184 ! cytoplasmic translational termination
relationship: regulates GO:0002184 ! cytoplasmic translational termination
created_by: vw
creation_date: 2014-12-10T15:48:55Z

[Term]
id: GO:1990581
name: obsolete lysosome lysis
namespace: biological_process
def: "OBSOLETE. The rupture of the lysosomal membrane and loss of contents as a result of osmotic change, G-protein-driven disintegration, or unspecified cause." [PMID:24472, PMID:9538255]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
subset: termgenie_unvetted
synonym: "lysosomal lysis" EXACT []
synonym: "lysosome lysis" EXACT []
is_obsolete: true
created_by: sl
creation_date: 2014-12-10T18:54:00Z

[Term]
id: GO:1990582
name: obsolete intracellular membrane-bounded organelle binding
namespace: molecular_function
def: "OBSOLETE. The temporary binding of a protein or protein complex to the membrane of an intracellular membrane-bounded organelle." [PMID:16100119, PMID:9538255]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
subset: termgenie_unvetted
synonym: "intracellular membrane-bounded organelle binding" EXACT []
synonym: "intracellular membrane-enclosed organelle binding" EXACT []
is_obsolete: true
created_by: sl
creation_date: 2014-12-10T19:37:09Z

[Term]
id: GO:1990583
name: phospholipase D activator activity
namespace: molecular_function
def: "Increases the activity of the enzyme phospholipase D." [PMID:7972129]
is_a: GO:0016004 ! phospholipase activator activity
relationship: positively_regulates GO:0004630 ! phospholipase D activity
created_by: sl
creation_date: 2014-12-10T21:04:46Z

[Term]
id: GO:1990584
name: cardiac Troponin complex
namespace: cellular_component
def: "A complex of accessory proteins (cardiac troponin T, cardiac troponin I and cardiac troponin C) found associated with actin in cardiac muscle thin filaments; involved in calcium regulation important for muscle contraction." [GOC:ame, IntAct:EBI-9980814, PMID:12840750]
synonym: "cTnC:cTnI:cTnT" RELATED []
is_a: GO:0005861 ! troponin complex
relationship: part_of GO:0030017 ! sarcomere
created_by: ame
creation_date: 2014-12-12T16:51:41Z

[Term]
id: GO:1990585
name: hydroxyproline O-arabinosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-beta-L-arabinofuranose + a [protein]-trans-4-hydroxy-L-proline <=> a protein-O-(beta-L-arabinofuranose)-trans-4-hydroxy-L-proline + UDP + H+." [EC:2.4.2, PMID:24036508]
synonym: "HPAT" EXACT []
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups
created_by: tb
creation_date: 2014-12-12T18:22:20Z

[Term]
id: GO:1990586
name: divisome complex
namespace: cellular_component
def: "A protein complex required for prokaryotic cell division (FtsZ-dependent cytokinesis). These complexes are assembled and recruited to the cell septum in a strictly controlled sequence and co-ordinate invagination of the cell membrane, inward growth of the peptidoglycan layer, constriction of the outer membrane and separation of daughter cells." [GOC:bhm, IntAct:EBI-9547109, IntAct:EBI-9997581, PMID:15165235, PMID:21784946]
is_a: GO:0043234 ! protein complex
is_a: GO:0044457 ! cell septum part
relationship: part_of GO:0030428 ! cell septum
created_by: bhm
creation_date: 2014-12-15T09:13:38Z

[Term]
id: GO:1990587
name: FtsQBL complex
namespace: cellular_component
def: "A protein complex required for prokaryotic cell division (FtsZ-dependent cytokinesis). Part of the divisome. Assembled independently of the other divisome components in the cytoplasm prior to transport to the cell septum. In E. coli consists of FtsB, FtsL and FtsQ." [GOC:bhm, IntAct:EBI-9997581, PMID:15165235, PMID:21784946]
comment: An example of this is FtsB in E. coli (P0A6S5) in PMID:15165235 (inferred from physical interaction).
synonym: "FtsB-FtsL-FtsQ complex" EXACT []
is_a: GO:1990586 ! divisome complex
created_by: bhm
creation_date: 2014-12-15T09:25:09Z

[Term]
id: GO:1990588
name: FtsBL complex
namespace: cellular_component
def: "A protein complex required for prokaryotic cell division (FtsZ-dependent cytokinesis). Part of the divisome. Assembled independently of the other divisome components in the cytoplasm prior to transport to the cell septum. In E. coli consists of FtsB and FtsL." [GOC:bhm, IntAct:EBI-9997581, PMID:15165235, PMID:21784946]
comment: An example of this is FtsB in E. coli (P0A6S5) in PMID:15165235 (inferred from physical interaction).
synonym: "FtsB-FtsL complex" EXACT []
is_a: GO:0044445 ! cytosolic part
is_a: GO:1990586 ! divisome complex
relationship: part_of GO:0005829 ! cytosol
relationship: part_of GO:1990587 ! FtsQBL complex
created_by: bhm
creation_date: 2014-12-15T09:33:00Z

[Term]
id: GO:1990589
name: ATF4-CREB1 transcription factor complex
namespace: cellular_component
def: "Transcription factor complex consisting of ATF4 and CREB1 subunits that is capable of binding to cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') as part of the positive regulation of transcription. Regulatory targets include the GRP78 (HSPA5) promoter in humans, whose activation by this complex is part of the ER stress response pathway." [GOC:bhm, IntAct:EBI-10043081, IntAct:EBI-10043332, PMID:12871976]
is_a: GO:0090575 ! RNA polymerase II transcription factor complex
relationship: part_of GO:0005634 ! nucleus
created_by: bhm
creation_date: 2014-12-15T14:22:44Z

[Term]
id: GO:1990590
name: ATF1-ATF4 transcription factor complex
namespace: cellular_component
def: "Transcription factor complex consisting of ATF1 and ATF4 subunits that is capable of binding to cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') of the GRP78 (HSPA5) promoter. Involved in the ER stress response pathway." [GOC:bhm, IntAct:EBI-10043123, IntAct:EBI-10043370, PMID:12871976]
comment: An example of this is ATF1in human (P18846) in PMID:12871976 (inferred from physical interaction).
is_a: GO:0090575 ! RNA polymerase II transcription factor complex
relationship: part_of GO:0005634 ! nucleus
created_by: bhm
creation_date: 2014-12-15T14:25:56Z

[Term]
id: GO:1990591
name: asparagine transmembrane import into vacuole
namespace: biological_process
def: "The directed movement of asparagine into the vacuole across the vacuolar membrane." [PMID:20388511]
is_a: GO:0032975 ! amino acid transmembrane import into vacuole
is_a: GO:0090469 ! asparagine import
is_a: GO:1903713 ! asparagine transmembrane transport
created_by: vw
creation_date: 2014-12-15T16:33:46Z

[Term]
id: GO:1990592
name: protein K69-linked ufmylation
namespace: biological_process
def: "A protein ufmylation process in which a polymer of the ubiquitin-like protein UFM1 is formed by linkages between lysine residues at position 69 of the UFM1 monomers, is added to a protein." [PMID:25219498]
is_a: GO:1990564 ! protein polyufmylation
created_by: jl
creation_date: 2014-12-15T17:01:23Z

[Term]
id: GO:1990593
name: nascent polypeptide-associated complex binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the nascent polypeptide-associated complex, which is a heterodimeric protein complex that can reversibly bind to ribosomes and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome." [PMID:25487825]
synonym: "NAC binding" EXACT []
synonym: "NACA binding" EXACT []
is_a: GO:0032403 ! protein complex binding
created_by: mcc
creation_date: 2014-12-15T22:20:45Z

[Term]
id: GO:1990594
name: L-altrarate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-altrarate = 5-dehydro-4-deoxy-D-glucarate + H(2)O." [PMID:17649980]
synonym: "L-talarate dehydratase activity" EXACT []
xref: RHEA:44031
is_a: GO:0016836 ! hydro-lyase activity
created_by: jl
creation_date: 2014-12-16T14:23:55Z

[Term]
id: GO:1990595
name: mast cell secretagogue receptor activity
namespace: molecular_function
def: "Combining with basic secretagogues to initiate pseudo-allergic reactions in mast cells." [GOC:sp, PMID:25517090]
is_a: GO:0004930 ! G-protein coupled receptor activity
created_by: sp
creation_date: 2014-12-22T10:04:43Z

[Term]
id: GO:1990596
name: histone H3-K4 deacetylation
namespace: biological_process
def: "The modification of histone H3 by the removal of an acetyl group from lysine at position 4 of the histone." [PMID:20299449]
is_a: GO:0070932 ! histone H3 deacetylation
created_by: al
creation_date: 2014-12-23T19:37:15Z

[Term]
id: GO:1990597
name: AIP1-IRE1 complex
namespace: cellular_component
def: "A protein complex consisting of IRE1 (inositol-requiring enzyme-1) bound to AIP1 (ASK1-interacting protein 1/DAB2-interacting protein)." [GOC:bf, GOC:PARL, PMID:18281285]
synonym: "AIP1-ERN1 complex" RELATED [HGNC:3449]
synonym: "IRE1-DAB2IP complex" EXACT [GOC:bf]
synonym: "IRE1alpha-AIP1 complex" NARROW [GOC:bf]
is_a: GO:0043234 ! protein complex
created_by: bf
creation_date: 2015-01-05T15:14:35Z

[Term]
id: GO:1990598
name: repair of mitotic mono-orientation defects
namespace: biological_process
def: "The mitotic cell cycle process where mono-orientation defects are corrected in order to ensure sister chromatids establish stable attachments to microtubules emanating from opposite spindle poles." [GOC:mtg_cell_cycle, GOC:vw, PMID:15525536]
synonym: "correction of mono-orientation defects" EXACT []
synonym: "correction of syntelic kinetochore attachment, mitotic" EXACT [GOC:vw]
is_a: GO:0072479 ! response to mitotic cell cycle spindle assembly checkpoint signaling
is_a: GO:1990758 ! mitotic sister chromatid biorientation
created_by: jl
creation_date: 2015-01-05T16:54:39Z

[Term]
id: GO:1990599
name: 3' overhang single-stranded DNA endodeoxyribonuclease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within 3' overhang single-stranded deoxyribonucleic acid by creating internal breaks." [PMID:25203555]
is_a: GO:0000014 ! single-stranded DNA endodeoxyribonuclease activity
created_by: al
creation_date: 2015-01-06T15:21:28Z

[Term]
id: GO:1990600
name: single-stranded DNA endodeoxyribonuclease activator activity
namespace: molecular_function
def: "Increases the activity of a single-stranded DNA endodeoxyribonuclease activator activity." [PMID:25203555]
is_a: GO:0008047 ! enzyme activator activity
relationship: part_of GO:0032079 ! positive regulation of endodeoxyribonuclease activity
created_by: al
creation_date: 2015-01-06T15:35:36Z

[Term]
id: GO:1990601
name: 5' overhang single-stranded DNA endodeoxyribonuclease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within 5' overhang single-stranded deoxyribonucleic acid by creating internal breaks." [PMID:25203555]
is_a: GO:0000014 ! single-stranded DNA endodeoxyribonuclease activity
created_by: al
creation_date: 2015-01-06T16:24:39Z

[Term]
id: GO:1990602
name: importin alpha-subunit nuclear import complex
namespace: cellular_component
def: "A trimeric protein complex which functions to shuttle the importin alpha-subunit into the nucleus through the nuclear pore to facilitate another round of mRNP incorporation and regulation. In Drosophila it consists of Cdm (Imp13), Mago and Tsu (Y14)." [GOC:bhm, IntAct:EBI-9673795, PMID:20122403]
comment: An example of this is Mago in drome (P49028) in PMID:20122403 (inferred by physical interaction).
synonym: "Cdm-Mago-Tsu complex" NARROW []
synonym: "Importin13-Mago-Tsu complex" NARROW []
is_a: GO:0031074 ! nucleocytoplasmic shuttling complex
created_by: bhm
creation_date: 2015-01-09T16:28:54Z

[Term]
id: GO:1990603
name: dark adaptation
namespace: biological_process
def: "The process by which the rods of the retina gradually become fully responsive to dim light when no longer exposed to bright light." [GOC:hjd, http://www.ncbi.nlm.nih.gov/books/NBK11525/, ISBN:0198506732]
comment: The proteins RGS9-1 and Gb5L localize to the rod inner segment during dark adaptation, but to the rod outer segment during light adaptation. PMID:23555598
is_a: GO:0071485 ! cellular response to absence of light
created_by: hjd
creation_date: 2015-01-09T20:35:46Z

[Term]
id: GO:1990604
name: IRE1-TRAF2-ASK1 complex
namespace: cellular_component
def: "A protein complex of the endoplasmic reticulum membrane that consists of IRE1 (Inositol-requiring enzyme-1), TRAF2 (TNF receptor-associated factor 2) and ASK1 (Apoptosis signal-regulating kinase 1, a MAP3K)." [GOC:bf, GOC:PARL, PMID:12050113, PMID:23000344]
synonym: "ERN1-TRAF2-ASK1 complex" RELATED [HGNC:3449]
is_a: GO:0044432 ! endoplasmic reticulum part
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane
created_by: bf
creation_date: 2015-01-13T15:03:04Z

[Term]
id: GO:1990605
name: GU repeat RNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA molecule containing GU repeats." [PMID:20081200]
is_a: GO:0003723 ! RNA binding
created_by: al
creation_date: 2015-01-13T18:18:01Z

[Term]
id: GO:1990606
name: membrane scission GTPase motor activity
namespace: molecular_function
def: "Catalysis of the generation of a 'twisting' activity resulting in the scission of a membrane, coupled to the hydrolysis of a nucleoside triphosphate." [PMID:11242086, PMID:23530241, PMID:24515348]
is_a: GO:0003774 ! motor activity
is_a: GO:0003924 ! GTPase activity
created_by: vw
creation_date: 2015-01-19T14:26:50Z

[Term]
id: GO:1990607
name: obsolete detection of stimulus involved in cytokinesis after mitosis checkpoint
namespace: biological_process
def: "OBSOLETE. The series of events in which information about whether cytokinesis has correctly completed, is received and converted into a molecular signal, contributing to a cytokinesis after mitosis checkpoint." [GOC:mtg_cell_cycle, GOC:vw, PMID:1234]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
subset: termgenie_unvetted
is_obsolete: true
created_by: jl
creation_date: 2015-01-19T14:43:34Z

[Term]
id: GO:1990608
name: mitotic spindle pole body localization to nuclear envelope
namespace: biological_process
def: "A process in which a mitotic spindle pole body is transported to, or maintained in, a specific location in the nuclear envelope." [PMID:24963130]
is_a: GO:0071789 ! spindle pole body localization to nuclear envelope
is_a: GO:1902580 ! single-organism cellular localization
is_a: GO:1903047 ! mitotic cell cycle process
created_by: vw
creation_date: 2015-01-19T17:12:03Z

[Term]
id: GO:1990609
name: glutamate-cysteine ligase regulator activity
namespace: molecular_function
def: "Binds to and modulates the activity of glutamate-cysteine ligase." [PMID:8103521]
is_a: GO:0030234 ! enzyme regulator activity
created_by: vw
creation_date: 2015-01-20T12:51:13Z

[Term]
id: GO:1990610
name: acetolactate synthase regulator activity
namespace: molecular_function
def: "Binds to and modulates the activity of acetolactate synthase." [PMID:8972574]
is_a: GO:0030234 ! enzyme regulator activity
created_by: vw
creation_date: 2015-01-20T12:54:43Z

[Term]
id: GO:1990611
name: regulation of cytoplasmic translational initiation in response to stress
namespace: biological_process
def: "Modulation of the frequency, rate or extent of cytoplasmic translational initiation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [PMID:16278445]
is_a: GO:0043558 ! regulation of translational initiation in response to stress
is_a: GO:1990497 ! regulation of cytoplasmic translation in response to stress
created_by: vw
creation_date: 2015-01-20T13:04:14Z

[Term]
id: GO:1990612
name: Sad1-Kms2 LINC complex
namespace: cellular_component
def: "A LINC complex implicated in the connection of DNA double strand breaks to the cytoskeleton during DNA double-strand break repair." [GOC:vw, PMID:24947240]
is_a: GO:0034993 ! LINC complex
is_a: GO:1990391 ! DNA repair complex
created_by: jl
creation_date: 2015-01-20T13:10:49Z

[Term]
id: GO:1990613
name: mitochondrial membrane fusion
namespace: biological_process
def: "The joining of two lipid bilayers that surround the mitochondria." [PMID:12052774]
is_a: GO:0007006 ! mitochondrial membrane organization
is_a: GO:0090174 ! organelle membrane fusion
intersection_of: GO:0061025 ! membrane fusion
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion
created_by: vw
creation_date: 2015-01-21T06:58:18Z

[Term]
id: GO:1990614
name: mitochondrial magnesium ion transmembrane transport
namespace: biological_process
def: "A process in which a magnesium ion is transported from one side of a mitochondrial membrane to the other by means of some agent such as a transporter or pore." [PMID:11254124]
is_a: GO:1903830 ! magnesium ion transmembrane transport
is_a: GO:1990542 ! mitochondrial transmembrane transport
created_by: mcc
creation_date: 2015-01-21T17:44:38Z

[Term]
id: GO:1990615
name: Kelch-containing formin regulatory complex
namespace: cellular_component
def: "A protein complex that regulates actin cable formation, polarized cell growth, and cytokinesis in a formin-dependent manner. In S. cerevisiae the complex is composed of Bud14p and two Kelch family proteins, Kel1p and Kel2p." [PMID:24828508]
synonym: "Bud14-Kel1-Kel2 complex" NARROW []
synonym: "KFRC complex" EXACT []
is_a: GO:0043234 ! protein complex
created_by: mcc
creation_date: 2015-01-21T18:48:51Z

[Term]
id: GO:1990616
name: magnesium ion export from mitochondrion
namespace: biological_process
def: "The directed movement of magnesium ions out of mitochondria into the cytosol by means of some agent such as a transporter or pore." [PMID:25585246]
synonym: "magnesium ion efflux from mitochondrion" EXACT []
is_a: GO:1990614 ! mitochondrial magnesium ion transmembrane transport
created_by: mcc
creation_date: 2015-01-21T22:06:42Z

[Term]
id: GO:1990617
name: CHOP-ATF4 complex
namespace: cellular_component
def: "A heterodimeric transcription factor complex that is composed of CHOP (C/EBP homology protein, GADD153) and ATF4 (activating transcription factor 4, also known as cAMP response element binding protein-2/CREB-2) subunits." [GOC:bf, GOC:PARL, PMID:18940792]
synonym: "ATF4-CHOP heterodimer" EXACT [PMID:18940792]
synonym: "CHOP-ATF4 heterodimer" EXACT [PMID:18940792]
synonym: "CHOP-CREB-2 complex" EXACT [PMID:11478948]
synonym: "CHOP/ATF4 complex" EXACT [PMID:18940792]
synonym: "GADD153-ATF4 complex" EXACT [GOC:bf]
is_a: GO:0090575 ! RNA polymerase II transcription factor complex
created_by: bf
creation_date: 2015-01-22T11:29:51Z

[Term]
id: GO:1990618
name: obsolete ANPR-A:ANP complex
namespace: cellular_component
def: "OBSOLETE. The ANPR-A:ANP complex is composed of the hormone AMP bound to the extracellular domain of ANPR-A domain. It is formed in the atrium in response to atrial distension (high blood volume) and leads to guanylate cyclase activity of the ANPR-A receptor, thereby elevating intracellular cGMP levels. The end result is a reduction in blood volume and, therefore, a reduction in cardiac output and systemic blood pressure. Therefore, ANPR-A:ANP complex plays a major role in the regulation of blood pressure and salt-fluid volume homeostasis." [GOC:ame, IntAct:EBI-10093340, PMID:15117952]
comment: An example of this is [ANPR-A:ANP] in [rat] (P18910:P01161-PRO_0000391785) in PMID:15117952 (inferred from direct assay).
subset: termgenie_unvetted
synonym: "ANPR-A:ANF   NPR1:ANP    NPR1:ANF" RELATED []
synonym: "ANPR-A:ANP complex" EXACT []
is_obsolete: true
created_by: ame
creation_date: 2015-01-23T15:17:47Z

[Term]
id: GO:1990619
name: histone H3-K9 deacetylation
namespace: biological_process
def: "The modification of histone H3 by the removal of an acetyl group from lysine at position 9 of the histone." [PMID:25002536]
is_a: GO:0070932 ! histone H3 deacetylation
created_by: al
creation_date: 2015-01-23T17:27:16Z

[Term]
id: GO:1990620
name: ANPR-A receptor complex
namespace: cellular_component
def: "A receptor complex composed of two ANPR-A molecules and expressed in the heart atrium in mammals; it plays a major role in the regulation of blood pressure and salt-fluid volume homeostasis. Binding of the ligand AMP in response to atrial distension (high blood volume) leads to guanylate cyclase activity of the ANPR-A receptor complex, thereby elevating intracellular cGMP levels. The end result is a reduction in blood volume and, therefore, a reduction in cardiac output and systemic blood pressure." [GOC:ame, IntAct:EBI-10093340, PMID:15117952]
comment: An example of this is Npr1 in rat (UniProt symbol P18910) in PMID:15117952 (inferred from direct assay).
synonym: "NPR1 receptor complex" RELATED []
is_a: GO:0043235 ! receptor complex
created_by: ame
creation_date: 2015-01-28T16:03:22Z

[Term]
id: GO:1990621
name: Vps4-Vta1 complex
namespace: cellular_component
def: "A protein complex involved in ESCRT-mediated intralumenal vesicle formation. The complex catalyzes disassembly of the ESCRT-III filament around the neck of the budding vesicle in an ATP-driven reaction, resulting in membrane scission and recycling of the ESCRT-III components back to the cytosol. In yeast, it is formed by the AAA ATPase Vps4 and its cofactor Vta1." [GOC:ha, PMID:20653365, PMID:20696398, PMID:25164817]
synonym: "Vps4 complex" BROAD []
synonym: "Vta1-Vps4 complex" EXACT []
is_a: GO:0044440 ! endosomal part
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0010008 ! endosome membrane
created_by: pr
creation_date: 2015-01-29T10:02:30Z

[Term]
id: GO:1990622
name: CHOP-ATF3 complex
namespace: cellular_component
def: "A heterodimeric protein complex that is composed of CHOP (C/EBP homology protein, GADD153) and ATF3 (activating transcription factor 3) subunits." [GOC:bf, GOC:PARL, PMID:8622660]
synonym: "ATF3-CHOP complex" EXACT [GOC:bf]
synonym: "CHOP-ATF3 heterodimer" EXACT [GOC:bf]
synonym: "CHOP-ATF3 heterodimeric complex" EXACT [GOC:bf]
synonym: "GADD153-ATF3 complex" EXACT [GOC:bf]
is_a: GO:0043234 ! protein complex
created_by: bf
creation_date: 2015-01-29T16:43:19Z

[Term]
id: GO:1990623
name: Herring body
namespace: cellular_component
def: "The dilated terminal portions of neurosecretory axons constituting the hypothalamohypophyseal tract, found in close proximity to sinusoidal capillaries in the posterior pituitary. Herring bodies consist of aggregates of membrane-bound neurosecretory vesicles where oxytocin or antidiuretic hormone (ADH) are stored prior to release. Each Herring body also contains ATP and either neurophysin I or neurophysin II which bind to oxytocin and ADH, respectively." [http://en.wikipedia.org/wiki/Herring_bodies, ISBN:0199652473]
synonym: "neurosecretory body" EXACT []
is_a: GO:0043679 ! axon terminus
created_by: cynthia.smith
creation_date: 2015-01-29T21:11:54Z

[Term]
id: GO:1990624
name: guanyl nucleotide exchange factor inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a guanyl nucleotide exchange factor." [GOC:vw, PMID:25635048]
is_a: GO:0030234 ! enzyme regulator activity
created_by: vw
creation_date: 2015-01-31T15:17:01Z

[Term]
id: GO:1990625
name: negative regulation of cytoplasmic translational initiation in response to stress
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate of cytoplasmic translation initiation as a result of a stimulus indicating the organism is under stress." [GOC:vw, PMID:12242291]
is_a: GO:0032057 ! negative regulation of translational initiation in response to stress
is_a: GO:1990611 ! regulation of cytoplasmic translational initiation in response to stress
is_a: GO:2000766 ! negative regulation of cytoplasmic translation
created_by: vw
creation_date: 2015-01-31T21:25:56Z

[Term]
id: GO:1990626
name: mitochondrial outer membrane fusion
namespace: biological_process
def: "The membrane organization process that joins two mitochondrial outer membranes to form a single membrane." [GOC:vw, PMID:21385840]
is_a: GO:0007008 ! outer mitochondrial membrane organization
is_a: GO:1990613 ! mitochondrial membrane fusion
created_by: vw
creation_date: 2015-02-02T11:32:17Z

[Term]
id: GO:1990627
name: mitochondrial inner membrane fusion
namespace: biological_process
def: "The membrane organization process that joins two mitochondrial outer membranes to form a single membrane." [GOC:vw, PMID:17055438]
is_a: GO:0007007 ! inner mitochondrial membrane organization
is_a: GO:1990613 ! mitochondrial membrane fusion
created_by: vw
creation_date: 2015-02-02T11:37:56Z

[Term]
id: GO:1990628
name: obsolete Sigma-E factor negative regulation complex
namespace: cellular_component
def: "OBSOLETE. A protein complex consisting of RseA, RseB and RpoE. It form the inactive form of the sigma-E transcription factor. In response to stress, outer membrane proteins accumulate in the periplasm and activate cleavage of RseA periplasmic domain by DegS, triggering a proteolytic cascade that frees sigma-E to activate gene expression. RseB binding to RseA prevents activated DegS from cleaving RseA. Sigma-E-mediated envelope stress response is the major pathway to ensure homeostasis in the envelope compartment of the cell." [GOC:bhm, IntAct:EBI-9019066, PMID:20190044]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
subset: termgenie_unvetted
synonym: "RseA-RseB-RpoE complex" RELATED []
synonym: "Sigma-E factor negative regulation complex" EXACT []
is_obsolete: true
created_by: bhm
creation_date: 2015-02-04T15:38:37Z

[Term]
id: GO:1990629
name: phospholamban complex
namespace: cellular_component
def: "A protein complex found as a homopentamer of the phospholamban (PLN) protein in the sarcoplasmic reticulum (SR) membrane of cardiomyocytes. Cardiac PLN is a main determinant of muscle contraction and relaxation, by regulating intracellular calcium levels." [GOC:ame, IntAct:EBI-10104734, PMID:16043693]
comment: An example of this is PLN in human (UniProt symbol P26678) in PMID:16043693 (inferred from direct assay).
synonym: "cardiac phospholamban complex" EXACT []
synonym: "cardiac PLB complex" RELATED []
synonym: "cardiac PLN complex" RELATED []
is_a: GO:0044432 ! endoplasmic reticulum part
is_a: GO:0098796 ! membrane protein complex
relationship: part_of GO:0033017 ! sarcoplasmic reticulum membrane
created_by: ame
creation_date: 2015-02-05T14:12:36Z

[Term]
id: GO:1990630
name: IRE1-RACK1-PP2A complex
namespace: cellular_component
def: "A protein complex consisting of IRE1 (Inositol-requiring enzyme-1), RACK1 (Receptor of activated protein kinase C 1, GNB2L1) and PP2A (protein phosphatase 2A). RACK1 acts as an adaptor to bridge an interaction between IRE1 and PP2A." [GOC:bf, GOC:PARL, PMID:20103773]
synonym: "ERN1-RACK1-PP2A complex" RELATED [HGNC:3449]
synonym: "IRE1alpha-RACK1-PP2A complex" NARROW [GOC:bf, PMID:20103773]
is_a: GO:0043234 ! protein complex
created_by: bf
creation_date: 2015-02-05T15:37:58Z

[Term]
id: GO:1990631
name: ErbB-4 class receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the protein-tyrosine kinase receptor ErbB-4/HER4." [GOC:sl, PMID:18523588]
synonym: "HER4 receptor binding" EXACT []
is_a: GO:0005102 ! receptor binding
created_by: sl
creation_date: 2015-02-06T23:28:49Z

[Term]
id: GO:1990632
name: branching involved in submandibular gland morphogenesis
namespace: biological_process
def: "The process in which the branching structure of the submandibular gland is generated and organized." [PMID:15063181, PMID:20890964]
synonym: "submandibular gland branching morphogenesis" EXACT [PMID:20890964]
synonym: "submandibular gland ductal branching" EXACT [PMID:20890964]
is_a: GO:0060445 ! branching involved in salivary gland morphogenesis
created_by: cynthia.smith
creation_date: 2015-02-10T14:40:01Z

[Term]
id: GO:1990633
name: mutator focus
namespace: cellular_component
def: "A type of punctate focus localized to the perinuclear region of germline cytoplasm in C. elegans. Mutator foci are required for RNA interference (RNAi) and serve as sites of small inhibitory RNA (siRNA) amplification. As such, proteins that localize to mutator foci include RNA-directed RNA polymerases (RdRPs) and beta-nucleotidyltransferases. Mutator foci are distinct from, but adjacent to or partially overlap, P granules." [PMID:22713602, PMID:25635455]
xref: GOC:kmv
is_a: GO:0036464 ! cytoplasmic ribonucleoprotein granule
relationship: part_of GO:0048471 ! perinuclear region of cytoplasm
created_by: kmv
creation_date: 2015-02-10T20:24:02Z

[Term]
id: GO:1990634
name: protein phosphatase 5 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the enzyme protein phosphatase 5." [PMID:8943293]
synonym: "protein phosphatase T binding" EXACT []
is_a: GO:0019903 ! protein phosphatase binding
created_by: sl
creation_date: 2015-02-10T21:30:41Z

[Term]
id: GO:1990635
name: proximal dendrite
namespace: cellular_component
def: "That part of the dendrite closest to the cell body of the neuron." [PMID:16899232]
is_a: GO:0044463 ! cell projection part
is_a: GO:0097458 ! neuron part
relationship: part_of GO:0030425 ! dendrite
created_by: sl
creation_date: 2015-02-10T22:57:16Z

[Term]
id: GO:1990636
name: reproductive senescence
namespace: biological_process
def: "A natural reduction in reproductive capacity with aging, often taking the form of a switch from regular reproductive cycles to irregular and infrequent ones." [PMID:24914937, PMID:25523082]
is_a: GO:0010259 ! multicellular organism aging
created_by: sl
creation_date: 2015-02-10T23:17:56Z

[Term]
id: GO:1990637
name: response to prolactin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prolactin stimulus. The anterior pituitary hormone prolactin has a number of roles including being essential for lactation." [PMID:7760850]
is_a: GO:0043434 ! response to peptide hormone
created_by: sl
creation_date: 2015-02-10T23:47:11Z

[Term]
id: GO:1990638
name: response to granulocyte colony-stimulating factor
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte colony-stimulating factor stimulus." [PMID:9488469]
synonym: "response to G-CSF" EXACT []
is_a: GO:0034097 ! response to cytokine
created_by: sl
creation_date: 2015-02-11T00:02:33Z

[Term]
id: GO:1990639
name: obsolete inositol-3,4,5-trisphosphate 5-phosphatase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: D-myo-inositol 3,4,5-trisphosphate + H2O = myo-inositol 3,4-bisphosphate + phosphate." [PMID:11348594]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
subset: termgenie_unvetted
synonym: "inositol-3,4,5-trisphosphate 5-phosphatase activity" EXACT []
is_obsolete: true
created_by: al
creation_date: 2015-02-11T15:58:56Z

[Term]
id: GO:1990640
name: inositol-2,4,5-triphosphate 5-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol 2,4,5-trisphosphate + H2O = 1D-myo-inositol 2,4-bisphosphate + phosphate." [PMID:15316017]
is_a: GO:0046030 ! inositol trisphosphate phosphatase activity
created_by: al
creation_date: 2015-02-11T18:20:40Z

[Term]
id: GO:1990641
name: response to iron ion starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of iron ion." [PMID:16208485]
is_a: GO:0042594 ! response to starvation
created_by: sl
creation_date: 2015-02-11T18:43:28Z

[Term]
id: GO:1990642
name: obsolete response to castration
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a castration stimulus, deprivation of gonads." [PMID:11255226]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
subset: termgenie_unvetted
synonym: "response to castration" EXACT []
is_obsolete: true
created_by: sl
creation_date: 2015-02-11T18:53:04Z

[Term]
id: GO:1990643
name: cellular response to granulocyte colony-stimulating factor
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte colony-stimulating factor stimulus." [PMID:9488469]
is_a: GO:0071345 ! cellular response to cytokine stimulus
is_a: GO:1990638 ! response to granulocyte colony-stimulating factor
created_by: sl
creation_date: 2015-02-11T19:22:44Z

[Term]
id: GO:1990644
name: microtubule site clamp
namespace: molecular_function
def: "The binding activity of a molecule that attaches the spindle microtubules to the kinetochore." [PMID:20723757]
is_a: GO:0030674 ! protein binding, bridging
created_by: vw
creation_date: 2015-02-13T15:50:13Z

[Term]
id: GO:1990645
name: obsolete phosphorylase dephosphorylation
namespace: biological_process
def: "OBSOLETE. The modification of phosphorylases by removal of phosphate groups." [PMID:8602837]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
subset: termgenie_unvetted
synonym: "phosphorylase dephosphorylation" EXACT []
is_obsolete: true
created_by: sl
creation_date: 2015-02-18T16:39:50Z

[Term]
id: GO:1990646
name: cellular response to prolactin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prolactin stimulus." [PMID:7760850]
is_a: GO:0071375 ! cellular response to peptide hormone stimulus
is_a: GO:1990637 ! response to prolactin
created_by: sl
creation_date: 2015-02-18T16:53:11Z

[Term]
id: GO:1990647
name: C/EBP complex
namespace: cellular_component
def: "A dimeric, sequence specific DNA-binding transcription factor complex regulating the expression of genes involved in immune and inflammatory responses. Exists at least as alpha and beta homodimeric forms. Binds to regulatory regions of several acute-phase and cytokines genes and probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Transcription factor activity is inhibited by binding of CHOP forming heterodimers with alternative transcription factor activities." [GOC:bhm, GOC:pad, GOC:PARL, IntAct:EBI-10637780, PMID:8657121]
comment: An example of this is Cebpa in rat (P05554) in PMID:8657121 (inferred from direct assay).
synonym: "C/EBP homodimer complex" EXACT []
synonym: "C/EBP transcription factor complex" EXACT []
synonym: "C/EBPalpha complex" NARROW []
synonym: "C/EBPalpha homodimer complex" NARROW []
synonym: "C/EBPbeta complex" NARROW []
synonym: "C/EBPbeta homodimer complex" NARROW []
is_a: GO:0090575 ! RNA polymerase II transcription factor complex
created_by: bhm
creation_date: 2015-02-19T11:00:09Z

[Term]
id: GO:1990648
name: inositol-4,5,6-triphosphate 5-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol 4,5,6-trisphosphate + H2O = 1D-myo-inositol 4,6-bisphosphate + phosphate." [GOC:al, PMID:15316017]
is_a: GO:0046030 ! inositol trisphosphate phosphatase activity
created_by: al
creation_date: 2015-02-23T11:10:51Z

[Term]
id: GO:1990649
name: inositol-1,2,4,5-tetrakisphosphate 5-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol 1,2,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,2,4-trisphosphate + phosphate." [GOC:al, PMID:15316017]
is_a: GO:0052743 ! inositol tetrakisphosphate phosphatase activity
created_by: al
creation_date: 2015-02-23T11:12:10Z

[Term]
id: GO:1990650
name: inositol-2,4,5,6-tetrakisphosphate 5-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol 2,4,5,6-tetrakisphosphate + H2O = 1D-myo-inositol 2,4,6-trisphosphate + phosphate." [GOC:al, PMID:15316017]
is_a: GO:0052743 ! inositol tetrakisphosphate phosphatase activity
created_by: al
creation_date: 2015-02-23T11:14:17Z

[Term]
id: GO:1990651
name: inositol-1,2,4,5,6-pentakisphosphate 5-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,4,6-tetrakisphosphate + phosphate." [GOC:al, PMID:15316017]
is_a: GO:0052827 ! inositol pentakisphosphate phosphatase activity
created_by: al
creation_date: 2015-02-23T11:17:19Z

[Term]
id: GO:1990652
name: obsolete positive regulation of pyrimidine-containing compound salvage by positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. A positive regulation of transcription from RNA polymerase II promoter that results in positive regulation of pyrimidine-containing compound salvage." [PMID:23695302]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
subset: termgenie_unvetted
synonym: "OBSOLETE positive regulation of pyrimidine-containing compound salvage by positive regulation of transcription from RNA polymerase II promoter" EXACT []
is_obsolete: true
created_by: al
creation_date: 2015-02-23T11:25:51Z

[Term]
id: GO:1990653
name: obsolete monounsaturated fatty acid biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of a monounsaturated fatty acid. A monounsaturated fatty acid has one double bond in the fatty acid chain with all of the remainder carbon atoms being single-bonded, as opposed to polyunsaturated fatty acids." [GOC:hjd, PMID:16443825]
comment: For example, stearoyl-coenzyme A desaturase (Scd) catalyzes the desaturation of saturated fatty acids to monounsaturated fatty acids in mammals and yeast.
subset: termgenie_unvetted
is_obsolete: true
created_by: hjd
creation_date: 2015-02-23T18:59:15Z

[Term]
id: GO:1990654
name: sebum secreting cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of sebocytes by cell division, resulting in the expansion of their population. A sebocyte is an epithelial cell that makes up the sebaceous glands, and secrete sebum." [GOC:hjd, PMID:16901790, PMID:18474083]
synonym: "sebocyte proliferation" RELATED [GOC:dph]
is_a: GO:0008283 ! cell proliferation
created_by: hjd
creation_date: 2015-02-23T19:43:49Z

[Term]
id: GO:1990655
name: 4 iron, 3 sulfur cluster binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a 4 iron, 3 sulfur (4Fe-3S) cluster, an uncommon iron-sulfur cluster with unique properties found in oxygen-tolerant Ni-Fe hydrogenases of various bacteria." [GOC:am, PMID:23267108]
synonym: "4Fe-3S cluster binding" RELATED []
is_a: GO:0051536 ! iron-sulfur cluster binding
created_by: pr
creation_date: 2015-02-24T17:07:23Z

[Term]
id: GO:1990656
name: t-SNARE clustering
namespace: biological_process
def: "The clustering process in which t-SNARES are localized to distinct domains in the cell membrane. t-SNAREs are cell surface proteins which are part of secretory microdomain assemblies." [PMID:22528485]
is_a: GO:0072657 ! protein localization to membrane
created_by: sl
creation_date: 2015-02-25T00:18:33Z

[Term]
id: GO:1990657
name: iNOS-S100A8/A9 complex
namespace: cellular_component
def: "A protein complex capable of stimulus-inducible nitric-oxide synthase activity. S-nitrosylates cysteine residues in target proteins, a principal mechanism of nitric oxide (NO)-mediated signal transduction. In mammals consists of NOS2, S100A8 and S100A9. S100A9 acts both as an adaptor linking NOS2 to its target and as a transnitrosylase that transfers the nitric oxide moiety from NOS2 to its target, via its own S-nitrosylated cysteine." [GOC:bhm, IntAct:EBI-10105915, IntAct:EBI-10106087, PMID:25417112]
comment: An example of this is NOS2 in human (UniProt symbol P35228) in PMID:25417112 (inferred from direct assay).
is_a: GO:1903958 ! nitric-oxide synthase complex
is_a: GO:1990658 ! transnitrosylase complex
relationship: part_of GO:0005737 ! cytoplasm
created_by: bhm
creation_date: 2015-02-25T11:00:49Z

[Term]
id: GO:1990658
name: transnitrosylase complex
namespace: cellular_component
def: "A transferase complex which is capable of transferring nitrogenous groups from one component to another." [GOC:bhm, IntAct:EBI-10105915, IntAct:EBI-10106087, PMID:25417112]
comment: An example of this is S100A9 in human (UniProt symbol P06702) in PMID:25417112 (inferred from direct assay).
synonym: "transferase complex, transferring nitrogenous groups" EXACT []
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:1990234 ! transferase complex
relationship: part_of GO:0005737 ! cytoplasm
created_by: bhm
creation_date: 2015-02-25T11:17:17Z

[Term]
id: GO:1990659
name: sequestering of manganese ion
namespace: biological_process
def: "The process of binding or confining manganese ions such that they are separated from other components of a biological system." [GOC:bhm, PMID:25417112]
comment: An example of this is S100A9 in human (UniProt symbol P06702) in PMID:25417112 (inferred from direct assay).
synonym: "manganese ion retention" EXACT []
synonym: "manganese ion sequestering" EXACT []
synonym: "manganese ion sequestration" EXACT []
synonym: "manganese ion storage" EXACT []
synonym: "retention of manganese ion" EXACT []
synonym: "sequestration of manganese ion" EXACT []
synonym: "storage of manganese ion" EXACT []
is_a: GO:0051238 ! sequestering of metal ion
relationship: part_of GO:0030026 ! cellular manganese ion homeostasis
created_by: bhm
creation_date: 2015-02-25T11:41:12Z

[Term]
id: GO:1990660
name: calprotectin complex
namespace: cellular_component
def: "A protein complex composed of S100A8 and S100A9 and capable of limiting Mn(2+) and Zn(2+) availability at sites of infection. Also binds Ca(2+). Expressed and released by neutrophils and epithelial cells, it exhibits broad-spectrum antimicrobial activity attributed to its metal-binding properties. Endogenous ligand of toll-like receptor 4 (TLR4) and of the receptor for advanced glycation end products (RAGE) initiating signal transduction through NF-kappa-B pathways." [GOC:bhm, IntAct:EBI-10098135, IntAct:EBI-10098681, IntAct:EBI-10098713, PMID:25417112]
comment: An example of this is S100A9 in human (UniProt symbol P06702) in PMID:25417112 (inferred from direct assay).
synonym: "calprotectin heterodimer" NARROW []
is_a: GO:0043234 ! protein complex
created_by: bhm
creation_date: 2015-02-25T14:03:17Z

[Term]
id: GO:1990661
name: S100A8 complex
namespace: cellular_component
def: "A protein complex composed of a S100A8 dimer and capable of binding to toll-like receptor 4 (TLR4)." [GOC:bhm, IntAct:EBI-10098921, IntAct:EBI-10099454, PMID:25417112]
comment: An example of this is S100A8 in human (UniProt symbol P27005) in PMID:25417112 (inferred from direct assay).
synonym: "S100A8 homodimer" EXACT []
is_a: GO:0043234 ! protein complex
created_by: bhm
creation_date: 2015-02-25T15:33:32Z

[Term]
id: GO:1990662
name: S100A9 complex
namespace: cellular_component
def: "A protein complex composed of a S100A9 dimer and capable of binding to toll-like receptor 4 (TLR4) and the receptor for advanced glycation end products (RAGE) initiating signal transduction through NF-kappa-B pathways. Transports arachidonic acid between the cytosol and the NADPH oxidase complex at the plasma membrane in neutrophils as part of an inflammatory signal cascade leading to an oxidative burst. Complexes with microtubules to increase cell motility." [GOC:bhm, IntAct:EBI-10098921, IntAct:EBI-10099454, PMID:15642721]
comment: An example of this is S100A9 in human (UniProt symbol P06702) in PMID:15642721 (inferred from direct assay).
synonym: "S100A9 homodimer" EXACT []
is_a: GO:1990351 ! transporter complex
created_by: bhm
creation_date: 2015-02-25T15:55:48Z

[Term]
id: GO:1990663
name: dihydroorotate dehydrogenase (fumarate) activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-dihydroorotate + fumarate = orotate + succinate." [PMID:1409592]
xref: EC:1.3.98.1
is_a: GO:0004152 ! dihydroorotate dehydrogenase activity
created_by: al
creation_date: 2015-02-26T15:47:30Z

[Term]
id: GO:1990664
name: Nkx-2.5 complex
namespace: cellular_component
def: "A transcription factor complex formed by two or more subunits of Nkx-2.5. Nkx-2.5 is an evolutionary conserved transcription factor important for the specification and differentiation of cardiomyocytes during heart development. It is also required for spleen development. It binds DNA either as a monomer, or a homodimer, or a heterodimer complex to activate or inhibit expression of genes." [GOC:ame, IntAct:EBI-10636829, PMID:22849347]
comment: An example of this is Nkx-2.5 in human (UniProt symbol P52952) in PMID:22849347 (inferred from direct assay).
synonym: "Nkx-2.5 homodimer complex" NARROW []
synonym: "NKX.2-5 homodimer complex" RELATED []
synonym: "NKX2.5 complex" RELATED []
synonym: "NKX2E homodimer complex" RELATED []
is_a: GO:0044798 ! nuclear transcription factor complex
created_by: ame
creation_date: 2015-02-27T12:22:06Z

[Term]
id: GO:1990665
name: AnxA2-p11 complex
namespace: cellular_component
def: "A heterotetrameric protein complex comprising two Annexin A2 (AnxA2) monomers and two copies of its binding partner, S100 protein p11 (S100A10)." [GOC:bf, GOC:BHF, GOC:nc, PMID:18799458, PMID:23483454]
synonym: "(A2.p11)2 complex" EXACT [PMID:23483454]
synonym: "(p11)2.(AnxA2)2 complex" EXACT [PMID:18799458]
synonym: "Annexin A2 tetramer" RELATED [PMID:23483454]
synonym: "Annexin A2-p11 complex" EXACT [GOC:bf]
synonym: "AnxA2.p11 complex" EXACT [PMID:18799458]
synonym: "AnxA2:S100A10 heterotetramer" EXACT [PMID:23483454]
is_a: GO:0043234 ! protein complex
created_by: bf
creation_date: 2015-03-02T10:07:42Z

[Term]
id: GO:1990666
name: PCSK9-LDLR complex
namespace: cellular_component
def: "A protein complex consisting of the serine protease PCSK9 (Proprotein convertase subtilisin/kexin-9) and a low-density lipoprotein receptor (LDLR). Interaction typically occurs through the epidermal growth factor-like repeat A (EGF-A) domain of the LDLR, and complex formation promotes degradation of the LDLR through the endosome/lysosome pathway." [GOC:BHF, GOC:nc, PMID:18250299, PMID:24440079]
synonym: "PCSK9.LDLR complex" EXACT [PMID:18799458]
synonym: "PCSK9/LDL-R complex" EXACT [PMID:24440079]
synonym: "PCSK9:EGF-A complex" RELATED [PMID:18250299]
synonym: "PCSK9:low-density lipoprotein receptor complex" EXACT [GOC:bf]
is_a: GO:0043234 ! protein complex
created_by: bf
creation_date: 2015-03-02T10:19:15Z

[Term]
id: GO:1990667
name: PCSK9-AnxA2 complex
namespace: cellular_component
def: "A protein complex consisting of the serine protease PCSK9 (Proprotein convertase subtilisin/kexin-9) and Annexin A2 (AnxA2)." [GOC:BHF, GOC:nc, PMID:22848640]
synonym: "PCSK9-Annexin A2 complex" EXACT [GOC:bf]
synonym: "PCSK9.AnxA2 complex" EXACT [PMID:18799458]
synonym: "PCSK9:ANXA2 complex" EXACT [GOC:bf]
is_a: GO:0043234 ! protein complex
created_by: bf
creation_date: 2015-03-02T10:33:09Z

[Term]
id: GO:1990668
name: vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane
namespace: biological_process
def: "The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane of the ERGIC. This can involve anterograde or retrograde transport vesicles." [GOC:bhm, PMID:16038056, PMID:24119662]
synonym: "vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment membrane" EXACT []
synonym: "vesicle fusion with ER-Golgi intermediate compartment (ERGIC) membrane" EXACT []
synonym: "vesicle fusion with ER-Golgi intermediate compartment membrane" EXACT []
synonym: "vesicle fusion with ERGIC membrane" EXACT []
is_a: GO:0006906 ! vesicle fusion
relationship: part_of GO:0016192 ! vesicle-mediated transport
created_by: bhm
creation_date: 2015-03-02T11:17:32Z

[Term]
id: GO:1990669
name: endoplasmic reticulum-Golgi intermediate compartment (ERGIC) derived vesicle fusion with endoplasmic reticulum membrane
namespace: biological_process
def: "The joining of the lipid bilayer membrane around an ERGIC-derived vesicle to the lipid bilayer membrane of the ER. Such vesicles include COPI-coated transport vesicles involved in retrograde transport." [GOC:bhm, PMID:16038056, PMID:24119662]
synonym: "endoplasmic reticulum-Golgi intermediate compartment (ERGIC) derived vesicle fusion with ER membrane" EXACT []
synonym: "ER-Golgi intermediate compartment derived vesicle fusion with ER membrane" EXACT []
is_a: GO:0048279 ! vesicle fusion with endoplasmic reticulum
relationship: part_of GO:0006890 ! retrograde vesicle-mediated transport, Golgi to ER
created_by: bhm
creation_date: 2015-03-02T11:21:43Z

[Term]
id: GO:1990670
name: vesicle fusion with Golgi cis cisterna membrane
namespace: biological_process
def: "The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi cis cisterna. This can involve anterograde or retrograde transport vesicles." [GOC:bhm, PMID:16038056, PMID:24119662]
is_a: GO:0006906 ! vesicle fusion
relationship: part_of GO:0016192 ! vesicle-mediated transport
created_by: bhm
creation_date: 2015-03-02T11:25:19Z

[Term]
id: GO:1990671
name: vesicle fusion with Golgi medial cisterna membrane
namespace: biological_process
def: "The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi medial cisterna. This can involve anterograde or retrograde transport vesicles." [GOC:bhm, PMID:16038056, PMID:24119662]
is_a: GO:0048280 ! vesicle fusion with Golgi apparatus
created_by: bhm
creation_date: 2015-03-02T11:31:01Z

[Term]
id: GO:1990672
name: medial-Golgi-derived vesicle fusion with Golgi trans cisterna membrane
namespace: biological_process
def: "The joining of the lipid bilayer membrane around a medial-Golgi-derived vesicle to the lipid bilayer membrane around the Golgi trans cisterna. Vesicles are involved in anterograde transport." [GOC:bhm, PMID:16038056, PMID:24119662]
is_a: GO:0048210 ! Golgi vesicle fusion to target membrane
is_a: GO:0048280 ! vesicle fusion with Golgi apparatus
relationship: part_of GO:0048219 ! inter-Golgi cisterna vesicle-mediated transport
created_by: bhm
creation_date: 2015-03-02T11:34:39Z

[Term]
id: GO:1990673
name: intrinsic component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane
namespace: cellular_component
def: "The component of the ERGIC membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:bhm, PMID:16038056, PMID:24119662]
synonym: "intrinsic component of endoplasmic reticulum-Golgi intermediate compartment membrane" EXACT []
is_a: GO:0031300 ! intrinsic component of organelle membrane
is_a: GO:0044444 ! cytoplasmic part
intersection_of: GO:0031224 ! intrinsic component of membrane
intersection_of: part_of GO:0033116 ! endoplasmic reticulum-Golgi intermediate compartment membrane
relationship: part_of GO:0033116 ! endoplasmic reticulum-Golgi intermediate compartment membrane
created_by: bhm
creation_date: 2015-03-02T11:44:46Z

[Term]
id: GO:1990674
name: Golgi cis cisterna membrane
namespace: cellular_component
def: "The lipid bilayer surrounding any of the thin, flattened compartments that form the cis portion of the Golgi complex." [GOC:bhm, PMID:16038056, PMID:24119662]
synonym: "cis-Golgi cisterna membrane" EXACT []
is_a: GO:0032580 ! Golgi cisterna membrane
relationship: part_of GO:0000137 ! Golgi cis cisterna
created_by: bhm
creation_date: 2015-03-02T11:48:00Z

[Term]
id: GO:1990675
name: Golgi medial cisterna membrane
namespace: cellular_component
def: "The lipid bilayer surrounding any of the thin, flattened compartments that form the medial portion of the Golgi complex." [GOC:bhm, PMID:16038056, PMID:24119662]
synonym: "medial-Golgi cisterna membrane" EXACT []
is_a: GO:0032580 ! Golgi cisterna membrane
relationship: part_of GO:0005797 ! Golgi medial cisterna
created_by: bhm
creation_date: 2015-03-02T11:50:29Z

[Term]
id: GO:1990676
name: Golgi trans cisterna membrane
namespace: cellular_component
def: "The lipid bilayer surrounding any of the thin, flattened compartments that form the trans portion of the Golgi complex." [GOC:bhm, PMID:16038056, PMID:24119662]
synonym: "trans-Golgi cisterna membrane" EXACT []
is_a: GO:0032580 ! Golgi cisterna membrane
relationship: part_of GO:0000138 ! Golgi trans cisterna
created_by: bhm
creation_date: 2015-03-02T11:53:35Z

[Term]
id: GO:1990677
name: mitochondrial inner membrane assembly complex
namespace: cellular_component
def: "A protein complex that promotes the biogenesis of mitochondrial F1Fo-ATP synthase by facilitating assembly of the peripheral stalk. Loss of INAC function causes dissociation of the F1-domain from the membrane-integral Fo-portion." [GOC:bhm, PMID:24942160]
comment: An example of this is INA22 in Saccharomyces cerevisiae (P40576) in PMID:24942160 (inferred from direct assay/mutant phenotype/etc.).
synonym: "INAC complex" EXACT []
synonym: "inner membrane assembly complex" BROAD []
is_a: GO:0098800 ! inner mitochondrial membrane protein complex
relationship: part_of GO:0005743 ! mitochondrial inner membrane
created_by: bhm
creation_date: 2015-03-02T13:14:52Z

[Term]
id: GO:1990678
name: histone H4-K16 deacetylation
namespace: biological_process
def: "The modification of histone H4 by the removal of an acetyl group from lysine at position 16 of the histone." [PMID:17446861]
is_a: GO:0070933 ! histone H4 deacetylation
created_by: al
creation_date: 2015-03-02T15:25:56Z

[Term]
id: GO:1990679
name: histone H4-K12 deacetylation
namespace: biological_process
def: "The modification of histone H4 by the removal of an acetyl group from lysine at position 12 of the histone." [PMID:17446861]
is_a: GO:0070933 ! histone H4 deacetylation
created_by: al
creation_date: 2015-03-02T15:40:44Z

[Term]
id: GO:1990680
name: response to melanocyte-stimulating hormone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a melanocyte-stimulating hormone stimulus. The binding of any one of three melanocyte-stimulating hormones causes dispersal of melanosomes in melanophores of poikilothermic vertebrates." [PMID:17036007]
synonym: "response to MSH" EXACT []
is_a: GO:0043434 ! response to peptide hormone
created_by: sl
creation_date: 2015-03-02T20:49:46Z

[Term]
id: GO:1990681
name: protein phosphatase type 2A inhibitor activity
namespace: molecular_function
def: "Decrease the activity of the enzyme protein phosphatase type 2A." [GOC:rb, PMID:18762578]
synonym: "protein phosphatase 2 inhibitor activity" RELATED [GOC:dph]
is_a: GO:0004864 ! protein phosphatase inhibitor activity
is_a: GO:0008601 ! protein phosphatase type 2A regulator activity
relationship: part_of GO:0034048 ! negative regulation of protein phosphatase type 2A activity
created_by: rb
creation_date: 2015-03-03T23:57:25Z

[Term]
id: GO:1990682
name: CSF1-CSF1R complex
namespace: cellular_component
def: "A protein complex consisting of a macrophage colony-stimulating factor (CSF1, also called M-CSF) dimer bound to a dimerized receptor (CSF1R, also called FMS). Receptor dimerization requires the presence of the ligand." [GOC:bf, GOC:BHF, GOC:nc, PMID:19017797]
synonym: "CSF1:C-FMS complex" EXACT [HGNC:2432, HGNC:2433]
synonym: "M-CSF:C-FMS complex" RELATED [GOC:nc]
synonym: "M-CSF:CSF1R complex" RELATED [HGNC:2432, HGNC:2433]
synonym: "M-CSF:FMS complex" EXACT [PMID:19017797]
synonym: "macrophage colony-stimulating factor:receptor complex" EXACT [GOC:bf]
is_a: GO:0043234 ! protein complex
created_by: bf
creation_date: 2015-03-10T12:23:03Z

[Term]
id: GO:1990683
name: DNA double-strand break attachment to nuclear envelope
namespace: biological_process
def: "A process in which the DNA double-strand breaks are attached to the inner surface of the nuclear envelope proximal to the spindle pole body, or iMTOCs." [PMID:24943839]
is_a: GO:0097240 ! chromosome attachment to the nuclear envelope
created_by: vw
creation_date: 2015-03-10T16:36:21Z

[Term]
id: GO:1990684
name: protein-lipid-RNA complex
namespace: cellular_component
def: "A macromolecular complex containing separate protein, lipid and RNA molecules. Separate in this context means not covalently bound to each other." [GOC:vesicles, PMID:21423178, PMID:22028337, PMID:23559634]
comment: Examples of protein-lipid-RNA complexes are described in PMID:21423178 and PMID:23559634, both showing evidence that high-density lipoprotein (HDL) and, to a lesser extent, low-density lipoprotein (HDL) transport endogenous microRNAs (miRNAs) and deliver them to recipient cells with functional targeting capabilities. Also see fig. 1 in the review PMID:22028337. Not to be confused with GO:0034364 'high-density lipoprotein particle' or GO:0034362 'low-density lipoprotein particle', which describe complexes of proteins and lipids only, without RNAs.
synonym: "miRNA-lipoprotein complex" RELATED []
is_a: GO:0032991 ! macromolecular complex
created_by: pr
creation_date: 2015-03-11T14:24:33Z

[Term]
id: GO:1990685
name: HDL-containing protein-lipid-RNA complex
namespace: cellular_component
def: "A protein-lipid-RNA complex containing separate high-density lipoprotein (HDL), lipid and RNA molecules. Separate in this context means not covalently bound to each other." [GOC:vesicles, PMID:21423178, PMID:23559634]
comment: Examples of HDL-containing protein-lipid-RNA complexes are described in PMID:21423178 and PMID:23559634, both showing evidence that high-density lipoproteins (HDL) transport endogenous microRNAs (miRNAs) and deliver them to recipient cells with functional targeting capabilities. Also see fig. 1 in the review PMID:22028337. Not to be confused with GO:0034364 'high-density lipoprotein particle', which describes complexes of proteins and lipids only, without RNAs.
is_a: GO:1990684 ! protein-lipid-RNA complex
created_by: pr
creation_date: 2015-03-11T14:56:52Z

[Term]
id: GO:1990686
name: LDL-containing protein-lipid-RNA complex
namespace: cellular_component
def: "A protein-lipid-RNA complex containing separate low-density lipoprotein (LDL), lipid and RNA molecules. Separate in this context means not covalently bound to each other." [GOC:vesicles, PMID:23559634]
comment: Examples of LDL-containing protein-lipid-RNA complexes are described in PMID:21423178 and PMID:23559634, both showing evidence that high-density lipoprotein (HDL) and, to a lesser extent, low-density lipoprotein (HDL) transport endogenous microRNAs (miRNAs) and deliver them to recipient cells with functional targeting capabilities. Also see fig. 1 in the review PMID:22028337. Not to be confused with GO:0034362 'low-density lipoprotein particle', which describe complexes of proteins and lipids only, without RNAs.
is_a: GO:1990684 ! protein-lipid-RNA complex
created_by: pr
creation_date: 2015-03-11T15:11:34Z

[Term]
id: GO:1990687
name: endoplasmic reticulum-derived vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane
namespace: biological_process
def: "The joining of the lipid bilayer membrane around an endoplasmic reticulum-derived vesicle to the lipid bilayer membrane of the ERGIC. Such vesicles include COPII-coated transport vesicles involved in anterograde transport." [GOC:bhm, PMID:16038056, PMID:24119662]
synonym: "ER-derived vesicle fusion with ER-Golgi intermediate compartment membrane" EXACT []
synonym: "ER-derived vesicle fusion with ERGIC membrane" EXACT []
is_a: GO:1990668 ! vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane
relationship: part_of GO:0006888 ! ER to Golgi vesicle-mediated transport
created_by: bhm
creation_date: 2015-03-12T09:31:45Z

[Term]
id: GO:1990688
name: Golgi vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane
namespace: biological_process
def: "The joining of the lipid bilayer membrane around a Golgi vesicle to the lipid bilayer membrane of the ERGIC. Such vesicles include COPI-coated transport vesicles involved in retrograde transport." [GOC:bhm, PMID:16038056, PMID:24119662]
synonym: "Golgi vesicle fusion with ER-Golgi intermediate compartment membrane" EXACT []
synonym: "Golgi vesicle fusion with ERGIC membrane" EXACT []
is_a: GO:1990668 ! vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane
relationship: part_of GO:0006890 ! retrograde vesicle-mediated transport, Golgi to ER
created_by: bhm
creation_date: 2015-03-12T09:34:21Z

[Term]
id: GO:1990689
name: endoplasmic reticulum-Golgi intermediate compartment (ERGIC) derived vesicle fusion with Golgi cis cisterna membrane
namespace: biological_process
def: "The joining of the lipid bilayer membrane around an ERGIC-derived vesicle to the lipid bilayer membrane around the Golgi cis cisterna. Such vesicles include COPII-coated transport vesicles involved in anterograde transport." [GOC:bhm, PMID:16038056, PMID:24119662]
synonym: "endoplasmic reticulum-Golgi intermediate compartment (ERGIC) derived vesicle fusion with cis-Golgi cisterna membrane" EXACT []
synonym: "ER-Golgi intermediate compartment derived vesicle fusion with cis-Golgi cisterna membrane" EXACT []
synonym: "ER-Golgi intermediate compartment derived vesicle fusion with Golgi cis cisterna membrane" EXACT []
synonym: "ERGIC-derived vesicle fusion with cis-Golgi cisterna membrane" EXACT []
synonym: "ERGIC-derived vesicle fusion with Golgi cis cisterna membrane" EXACT []
is_a: GO:0048280 ! vesicle fusion with Golgi apparatus
is_a: GO:1990670 ! vesicle fusion with Golgi cis cisterna membrane
relationship: part_of GO:0006888 ! ER to Golgi vesicle-mediated transport
created_by: bhm
creation_date: 2015-03-12T09:41:48Z

[Term]
id: GO:1990690
name: Golgi medial cisterna-derived vesicle fusion with Golgi cis cisterna membrane
namespace: biological_process
def: "The joining of the lipid bilayer membrane around a Golgi medial cisterna-derived vesicle to the lipid bilayer membrane around the Golgi cis cisterna. Such vesicles include COPI-coated transport vesicles involved in retrograde transport." [GOC:bhm, PMID:16038056, PMID:24119662]
synonym: "medial-Golgi cisterna-derived vesicle fusion with cis-Golgi cisterna membrane" EXACT []
is_a: GO:0048210 ! Golgi vesicle fusion to target membrane
is_a: GO:0048280 ! vesicle fusion with Golgi apparatus
relationship: part_of GO:0000301 ! retrograde transport, vesicle recycling within Golgi
created_by: bhm
creation_date: 2015-03-12T09:47:03Z

[Term]
id: GO:1990691
name: cis-Golgi-derived vesicle fusion with Golgi medial cisterna membrane
namespace: biological_process
def: "The joining of the lipid bilayer membrane around a cis-Golgi-derived vesicle to the lipid bilayer membrane around the medial-Golgi cisterna. Vesicles are involved in anterograde transport." [GOC:bhm, PMID:16038056, PMID:24119662]
synonym: "cis-Golgi-derived vesicle fusion with medial-Golgi cisterna membrane" EXACT []
is_a: GO:0048210 ! Golgi vesicle fusion to target membrane
is_a: GO:0048280 ! vesicle fusion with Golgi apparatus
relationship: part_of GO:0048219 ! inter-Golgi cisterna vesicle-mediated transport
created_by: bhm
creation_date: 2015-03-12T09:51:01Z

[Term]
id: GO:1990692
name: trans-Golgi-derived vesicle fusion with Golgi medial cisterna membrane
namespace: biological_process
def: "The joining of the lipid bilayer membrane around a trans-Golgi-derived vesicle to the lipid bilayer membrane around the medial-Golgi cisterna. Such vesicles include COPI-coated transport vesicles involved in retrograde transport." [GOC:bhm, PMID:16038056, PMID:24119662]
synonym: "trans-Golgi-derived vesicle fusion with medial-Golgi cisterna membrane" EXACT []
is_a: GO:0048210 ! Golgi vesicle fusion to target membrane
is_a: GO:0048280 ! vesicle fusion with Golgi apparatus
relationship: part_of GO:0000301 ! retrograde transport, vesicle recycling within Golgi
created_by: bhm
creation_date: 2015-03-12T09:54:02Z

[Term]
id: GO:1990693
name: intrinsic component of Golgi cis cisterna membrane
namespace: cellular_component
def: "The component of the Golgi cis cisterna membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:bhm, PMID:16038056, PMID:24119662]
synonym: "intrinsic component of cis-Golgi cisterna membrane" EXACT []
is_a: GO:0031228 ! intrinsic component of Golgi membrane
intersection_of: GO:0031224 ! intrinsic component of membrane
intersection_of: part_of GO:1990674 ! Golgi cis cisterna membrane
relationship: part_of GO:1990674 ! Golgi cis cisterna membrane
created_by: bhm
creation_date: 2015-03-12T10:24:07Z

[Term]
id: GO:1990694
name: intrinsic component of Golgi medial cisterna membrane
namespace: cellular_component
def: "The component of the Golgi medial cisterna membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:bhm, PMID:16038056, PMID:24119662]
synonym: "intrinsic component of medial-Golgi cisterna membrane" EXACT []
is_a: GO:0031228 ! intrinsic component of Golgi membrane
intersection_of: GO:0031224 ! intrinsic component of membrane
intersection_of: part_of GO:1990675 ! Golgi medial cisterna membrane
relationship: part_of GO:1990675 ! Golgi medial cisterna membrane
created_by: bhm
creation_date: 2015-03-12T10:29:12Z

[Term]
id: GO:1990695
name: intrinsic component of Golgi trans cisterna membrane
namespace: cellular_component
def: "The component of the Golgi trans cisterna membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:bhm, PMID:16038056, PMID:24119662]
synonym: "intrinsic component of trans-Golgi cisterna membrane" EXACT []
is_a: GO:0031228 ! intrinsic component of Golgi membrane
intersection_of: GO:0031224 ! intrinsic component of membrane
intersection_of: part_of GO:1990676 ! Golgi trans cisterna membrane
relationship: part_of GO:1990676 ! Golgi trans cisterna membrane
created_by: bhm
creation_date: 2015-03-12T10:36:02Z

[Term]
id: GO:1990696
name: USH2 complex
namespace: cellular_component
def: "A protein complex composed of four proteins, loss of which results in Usher Syndrome type 2 (USH2 syndrome), a leading genetic cause of combined hearing and vision loss. This complex is conserved in many species; in mice, it is composed of USH2A, GPR98 (aka ADGRV1), WHRN, and PDZD7." [GOC:krc, PMID:25406310]
synonym: "USH2 quaternary protein complex" EXACT []
is_a: GO:0043234 ! protein complex
created_by: krc
creation_date: 2015-03-12T17:29:18Z

[Term]
id: GO:1990697
name: protein depalmitoleylation
namespace: biological_process
def: "The removal of palmitoleyl group, a 16-carbon monounsaturated fatty acid (C16:1), from a lipoprotein." [PMID:25731175]
is_a: GO:0035601 ! protein deacylation
is_a: GO:0042159 ! lipoprotein catabolic process
created_by: sp
creation_date: 2015-03-13T08:55:31Z

[Term]
id: GO:1990698
name: palmitoleoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a palmitoleyl group, a 16-carbon monounsaturated fatty acid (C16:1), to an acceptor molecule." [PMID:17141155, PMID:25731175]
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups
created_by: sp
creation_date: 2015-03-13T08:58:25Z

[Term]
id: GO:1990699
name: palmitoleyl hydrolase activity
namespace: molecular_function
def: "Catalysis of a hydrolase reaction that removes a palmitoleyl moiety, a 16-carbon monounsaturated fatty acid (C16:1), from some substrate." [PMID:25731175]
is_a: GO:0052689 ! carboxylic ester hydrolase activity
created_by: sp
creation_date: 2015-03-13T09:00:05Z

[Term]
id: GO:1990700
name: nucleolar chromatin organization
namespace: biological_process
def: "Any process that results in the specification, formation or maintenance of the physical structure of nucleolar chromatin." [PMID:18362178]
synonym: "establishment or maintenance of nucleolar chromatin architecture" EXACT []
synonym: "nucleolar chromatin organisation" EXACT []
is_a: GO:0016043 ! cellular component organization
relationship: part_of GO:0006325 ! chromatin organization
created_by: mah
creation_date: 2015-03-16T12:11:01Z

[Term]
id: GO:1990701
name: integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane
namespace: cellular_component
def: "The component of the ERGIC membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:bhm, PMID:16038056, PMID:24119662]
synonym: "integral component of endoplasmic reticulum-Golgi intermediate compartment membrane" EXACT []
synonym: "integral component of ER-Golgi intermediate compartment membrane" EXACT []
synonym: "integral component of ERGIC membrane" EXACT []
is_a: GO:0031301 ! integral component of organelle membrane
is_a: GO:1990673 ! intrinsic component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane
intersection_of: GO:0016021 ! integral component of membrane
intersection_of: part_of GO:0033116 ! endoplasmic reticulum-Golgi intermediate compartment membrane
relationship: part_of GO:0033116 ! endoplasmic reticulum-Golgi intermediate compartment membrane
created_by: bhm
creation_date: 2015-03-16T15:57:36Z

[Term]
id: GO:1990702
name: integral component of Golgi cis cisterna membrane
namespace: cellular_component
def: "The component of the Golgi cis membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:bhm, PMID:16038056, PMID:24119662]
synonym: "integral component of cis-Golgi cisterna membrane" EXACT []
is_a: GO:0030173 ! integral component of Golgi membrane
is_a: GO:1990693 ! intrinsic component of Golgi cis cisterna membrane
intersection_of: GO:0016021 ! integral component of membrane
intersection_of: part_of GO:1990674 ! Golgi cis cisterna membrane
relationship: part_of GO:1990674 ! Golgi cis cisterna membrane
created_by: bhm
creation_date: 2015-03-16T16:03:21Z

[Term]
id: GO:1990703
name: integral component of Golgi medial cisterna membrane
namespace: cellular_component
def: "The component of the Golgi medial membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:bhm, PMID:16038056, PMID:24119662]
synonym: "integral component of medial-Golgi cisterna membrane" EXACT []
is_a: GO:0030173 ! integral component of Golgi membrane
is_a: GO:1990694 ! intrinsic component of Golgi medial cisterna membrane
intersection_of: GO:0016021 ! integral component of membrane
intersection_of: part_of GO:1990675 ! Golgi medial cisterna membrane
relationship: part_of GO:1990675 ! Golgi medial cisterna membrane
created_by: bhm
creation_date: 2015-03-16T16:05:25Z

[Term]
id: GO:1990704
name: integral component of Golgi trans cisterna membrane
namespace: cellular_component
def: "The component of the Golgi trans membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:bhm, PMID:16038056, PMID:24119662]
synonym: "integral component of trans-Golgi cisterna membrane" EXACT []
is_a: GO:0030173 ! integral component of Golgi membrane
is_a: GO:1990695 ! intrinsic component of Golgi trans cisterna membrane
intersection_of: GO:0016021 ! integral component of membrane
intersection_of: part_of GO:1990676 ! Golgi trans cisterna membrane
relationship: part_of GO:1990676 ! Golgi trans cisterna membrane
created_by: bhm
creation_date: 2015-03-16T16:08:07Z

[Term]
id: GO:1990705
name: cholangiocyte proliferation
namespace: biological_process
def: "The multiplication or reproduction of cholangiocytes, resulting in the expansion of the cholangiocyte population. A cholangiocyte is an epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water." [PMID:24434010]
synonym: "hepatoblast proliferation" EXACT []
is_a: GO:0050673 ! epithelial cell proliferation
creation_date: 2015-03-16T23:23:50Z

[Term]
id: GO:1990706
name: MAD1 complex
namespace: cellular_component
def: "A protein complex involved in the assembly of the mitotic checkpoint complex that in turn inhibits the anaphase promoting complex/cyclosome (APC/C)." [GOC:bhm, IntAct:EBI-10691160, intAct:EBI-10691224, PMID:22493223, PMID:22898774]
synonym: "MAD1 homodimer" EXACT []
is_a: GO:0043234 ! protein complex
created_by: bhm
creation_date: 2015-03-17T15:49:16Z

[Term]
id: GO:1990707
name: nuclear subtelomeric heterochromatin
namespace: cellular_component
def: "Heterochromatic regions of the chromosome found at the subtelomeric regions of a chromosome in the nucleus." [PMID:7660126]
is_a: GO:0005720 ! nuclear heterochromatin
is_a: GO:1990421 ! subtelomeric heterochromatin
intersection_of: GO:1990421 ! subtelomeric heterochromatin
intersection_of: part_of GO:0005634 ! nucleus
relationship: part_of GO:0005634 ! nucleus
created_by: vw
creation_date: 2015-03-17T22:29:25Z

[Term]
id: GO:1990708
name: conditioned place preference
namespace: biological_process
def: "The associative learning process by which an animal learns and remembers an association between a neutral, unchanging environment and a putatively rewarding, internal state produced by a xenobiotic or drug." [PMID:21549821]
is_a: GO:0008306 ! associative learning
created_by: sl
creation_date: 2015-03-18T20:28:59Z

[Term]
id: GO:1990709
name: presynaptic active zone organization
namespace: biological_process
def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of a presynaptic active zone." [GOC:pr, PMID:16865347, PMID:17068967]
synonym: "presynaptic active zone organisation" EXACT []
is_a: GO:0016043 ! cellular component organization
relationship: part_of GO:0050808 ! synapse organization
created_by: pr
creation_date: 2015-03-20T10:16:24Z

[Term]
id: GO:1990710
name: MutS complex
namespace: cellular_component
def: "A homodimeric mismatch repair complex involved in binding to and correcting insertion/deletion mutations." [GOC:bhm, IntAct:EBI-10705937, PMID:21666597]
comment: An example of this is MutS in E. coli (UniProt symbol P23909) in PMID:21666597 (inferred from physical interaction).
synonym: "MutS mismatch repair complex" EXACT []
is_a: GO:0032300 ! mismatch repair complex
is_a: GO:1904949 ! ATPase complex
created_by: bhm
creation_date: 2015-03-25T11:42:56Z

[Term]
id: GO:1990711
name: Beta-catenin-ICAT complex
namespace: cellular_component
def: "Transcription factor complex that inhibits binding of Tcf to beta-catenin while preserving interaction of catenin with cadherin thus inhibiting transcription mediated by beta-catenin-Tcf complex." [GOC:bhm, IntAct:EBI-10691252, IntAct:EBI-10705284, PMID:12408824]
comment: An example of this is Catenin beta-1 in human (UniProt symbol P35222) in PMID:12408824 (inferred from physical interaction).
synonym: "CTNNB1-CTNNBIP1 complex" EXACT []
is_a: GO:0044451 ! nucleoplasm part
is_a: GO:0090575 ! RNA polymerase II transcription factor complex
relationship: part_of GO:0005654 ! nucleoplasm
created_by: bhm
creation_date: 2015-03-25T21:08:11Z

[Term]
id: GO:1990712
name: HFE-transferrin receptor complex
namespace: cellular_component
def: "A protein complex containing at least HFE and a transferrin receptor (either TFR1/TFRC or TFR2), proposed to play a role in the sensing of transferrin-bound Fe (Fe2-Tf) on the plasma membrane to regulate hepcidin transcription." [GOC:BHF, GOC:kom, PMID:25147378]
is_a: GO:0098802 ! plasma membrane receptor complex
relationship: part_of GO:0005886 ! plasma membrane
created_by: pr
creation_date: 2015-03-26T13:03:27Z

[Term]
id: GO:1990713
name: survivin complex
namespace: cellular_component
def: "A protein complex that negatively regulates apoptotic processes. In human, this anti-apoptotic complex is a homodimer of BIRC5 (survivin) and provides one survivin molecule to the chromosomal passenger complex (CPC)." [GOC:bhm, IntAct:EBI-10714791, IntAct:EBI-10727115, PMID:10949038]
comment: An example of this is BIRC5 in human (UniProt symbol O15392) in PMID:10949038 (inferred from physical interaction).
synonym: "Baculoviral IAP repeat-containing protein 5 complex" EXACT []
synonym: "survivin homodimer complex" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part
relationship: part_of GO:0005654 ! nucleoplasm
created_by: bhm
creation_date: 2015-03-26T14:21:46Z

[Term]
id: GO:1990714
name: hydroxyproline O-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of galactose from UDP-galactose to hydroxyproline residues present in the peptide backbone." [PMID:25600942]
synonym: "HPGT" EXACT []
is_a: GO:0008378 ! galactosyltransferase activity
created_by: tb
creation_date: 2015-03-26T23:22:09Z

[Term]
id: GO:1990715
name: mRNA CDS binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the coding sequence (CDS) of an mRNA molecule." [GOC:kmv, PMID:25805859, SO:0000316]
synonym: "mRNA coding region binding" EXACT []
synonym: "mRNA coding sequence binding" EXACT []
is_a: GO:0003729 ! mRNA binding
created_by: kmv
creation_date: 2015-03-27T20:59:49Z

[Term]
id: GO:1990716
name: axonemal central apparatus
namespace: cellular_component
def: "Part of the 9+2 axoneme, that occurs in most motile cilia, consisting of the pair of two single central microtubules and their associated structures which include the central pair projections, the central pair bridges linking the two tubules, and the central pair caps which are attached to the distal or plus ends of the microtubules." [GOC:cilia, PMID:21586547, PMID:9295136]
is_a: GO:0044447 ! axoneme part
created_by: krc
creation_date: 2015-03-27T22:33:23Z

[Term]
id: GO:1990717
name: axonemal central bridge
namespace: cellular_component
def: "Part of the 9+2 axoneme, that occurs in most motile cilia, consisting of the two bridges which connect the central pair of single microtubules." [GOC:cilia, PMID:21586547, PMID:9295136]
is_a: GO:0044447 ! axoneme part
relationship: part_of GO:1990716 ! axonemal central apparatus
created_by: krc
creation_date: 2015-03-27T22:38:31Z

[Term]
id: GO:1990718
name: axonemal central pair projection
namespace: cellular_component
def: "Part of the 9+2 axoneme, that occurs in most motile cilia, consisting of the projections off of the central pair of single microtubules." [GOC:cilia, PMID:21586547, PMID:9295136]
is_a: GO:0044447 ! axoneme part
relationship: part_of GO:1990716 ! axonemal central apparatus
created_by: krc
creation_date: 2015-03-27T22:43:01Z

[Term]
id: GO:1990719
name: C1 axonemal microtubule
namespace: cellular_component
def: "One of two microtubules present in the axonemal central pair. It is distinguishable from the C2 axonemal microtubule (also called C2 tubule) by the presence of differing protein components of the projections." [GOC:cilia, PMID:21586547, PMID:9295136]
synonym: "C1 tubule" BROAD []
is_a: GO:0005879 ! axonemal microtubule
relationship: part_of GO:0097540 ! axonemal central pair
created_by: krc
creation_date: 2015-03-27T22:55:12Z

[Term]
id: GO:1990720
name: C2 axonemal microtubule
namespace: cellular_component
def: "One of two microtubules present in the axonemal central pair. It is distinguishable from the C1 axonemal microtubule (also called C1 tubule) by the presence of differing protein components of the projections." [GOC:cilia, PMID:21586547, PMID:9295136]
synonym: "C2 tubule" BROAD []
is_a: GO:0005879 ! axonemal microtubule
relationship: part_of GO:0097540 ! axonemal central pair
created_by: krc
creation_date: 2015-03-27T22:58:40Z

[Term]
id: GO:1990721
name: obsolete prostatic acid phosphatase complex
namespace: cellular_component
def: "OBSOLETE. A protein complex that is capable of dephosphorylation of alky, aryl and acyl orthophosphate monoesters and phosphorylated proteins. Optimal activity in acidic environment (pH 4-6). In mammals it consists of a homodimer of ACPP." [GOC:bhm, IntAct:EBI-10758257, IntAct:EBI-10758292, PMID:12525165]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
subset: termgenie_unvetted
synonym: "ACPP homodimer complex" NARROW []
synonym: "PAP complex" EXACT []
synonym: "prostatic acid phosphatase complex" EXACT []
is_obsolete: true
created_by: bhm
creation_date: 2015-04-01T09:43:14Z

[Term]
id: GO:1990722
name: DAPK1-calmodulin complex
namespace: cellular_component
def: "A serine/threonine protein kinase complex involved in cell survival, apoptosis and autophagic cell death pathways. DAPK1 is activated by the dephosphorylation of a n-terminal serine and calcium-calmodulin binding." [GOC:bhm, IntAct:EBI-10758257, IntAct:EBI-10758292, PMID:20103772]
synonym: "death-associated protein kinase 1 - calmodulin complex" EXACT []
is_a: GO:0044464 ! cell part
is_a: GO:1902554 ! serine/threonine protein kinase complex
relationship: part_of GO:0005623 ! cell
created_by: bhm
creation_date: 2015-04-01T13:05:17Z

[Term]
id: GO:1990723
name: cytoplasmic periphery of the nuclear pore complex
namespace: cellular_component
def: "Cytoplasm situated in close proximity to a nuclear pore complex." [PMID:9398662]
is_a: GO:0048471 ! perinuclear region of cytoplasm
created_by: sl
creation_date: 2015-04-06T19:26:54Z

[Term]
id: GO:1990724
name: galectin complex
namespace: cellular_component
def: "A homodimeric protein complex that is capable of binding a range of carbohydrates and is involved in anti-inflammatory and pro-apoptotic processes." [GOC:bhm, IntAct:EBI-10705755, IntAct:EBI-10705946, IntAct:EBI-10705984, IntAct:EBI-10706026, PMID:15476813, PMID:18777589, PMID:8262940]
comment: An example of this is Galectin-1 in human (P09382) in PMID:15476813 (inferred from physical interaction).
synonym: "galectin-1 complex" NARROW []
synonym: "galectin-2 complex" NARROW []
is_a: GO:0098635 ! protein complex involved in cell-cell adhesion
created_by: bhm
creation_date: 2015-04-07T15:03:15Z

[Term]
id: GO:1990725
name: cord factor receptor activity
namespace: molecular_function
def: "Combining with a cord factor, an M. tuberculosis cell wall glycolipid, and transmitting a signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:hjd, PMID:23602766]
synonym: "TMD receptor activity" EXACT []
synonym: "trehalose 6,6'-dimycolate receptor activity" EXACT []
xref: Wikipedia:Cord_factor
is_a: GO:0038023 ! signaling receptor activity
created_by: hjd
creation_date: 2015-04-07T20:53:31Z

[Term]
id: GO:1990726
name: Lsm1-7-Pat1 complex
namespace: cellular_component
def: "A conserved protein complex that plays an important role in coupling deadenylation and decapping in the 5'-to-3' mRNA decay pathway. An example is found in S. cerevisiae." [GOC:jd, PMID:24139796]
is_a: GO:0043234 ! protein complex
created_by: pr
creation_date: 2015-04-08T09:22:36Z

[Term]
id: GO:1990727
name: tubulin folding cofactor complex
namespace: cellular_component
def: "A multimeric protein complex involved in tubulin alpha-beta-subunit folding assembly consisting of beta-tubulin-TFC-D, alpha-tubulin-TFC-E and TFC-C, through which tubulin subunit association and dimer release occur." [GOC:vw, PMID:12445400]
is_a: GO:0043234 ! protein complex
created_by: pr
creation_date: 2015-04-08T10:29:43Z

[Term]
id: GO:1990728
name: mitotic spindle assembly checkpoint MAD1-MAD2 complex
namespace: cellular_component
def: "A protein complex involved in the assembly of the mitotic checkpoint complex that in turn inhibits the anaphase promoting complex/cyclosome (APC/C). The MAD1 dimer recruits the open form of MAD2 (O-MAD2) turning it into the closed form (C-MAD2) upon binding. C-MAD2 inhibits CDC20, a member of the APC/C, upon release from the MAD1-MAD2 complex." [GOC:bhm, IntAct:EBI-10691260, IntAct:EBI-10705307, PMID:12006501, PMID:22898774]
comment: An example of this is MAD1 in human (Q9Y6D9) in PMID:12006501 (inferred from physical interaction).
synonym: "MAD1-MAD2 complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part
relationship: has_part GO:1990706 ! MAD1 complex
relationship: part_of GO:0005737 ! cytoplasm
created_by: bhm
creation_date: 2015-04-15T10:14:17Z

[Term]
id: GO:1990729
name: primary miRNA modification
namespace: biological_process
def: "The covalent alteration of one or more nucleotides within a primary miRNA molecule to produce a primary miRNA molecule with a sequence that differs from that coded genetically." [PMID:25799998]
is_a: GO:0009451 ! RNA modification
is_a: GO:0031053 ! primary miRNA processing
created_by: sp
creation_date: 2015-04-16T06:19:22Z

[Term]
id: GO:1990730
name: VCP-NSFL1C complex
namespace: cellular_component
def: "A protein complex between the ATPase VCP (p97) and its cofactor p47 (NSFL1C). In human, the protein complex consists of one homotrimer of NSFL1C/p47 per homohexamer of VCP/p97." [GOC:bf, GOC:PARL, PMID:9214505]
synonym: "p97-p47 complex" EXACT [GOC:bf, PMID:12847084]
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part
created_by: bf
creation_date: 2015-04-20T12:27:35Z

[Term]
id: GO:1990731
name: UV-damage excision repair, DNA incision
namespace: biological_process
def: "A process that results in the endonucleolytic cleavage of the damaged strand of DNA immediately 5' of a UV-induced damage site, and is the first part of a DNA repair process that acts on both cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone 6-4 photoproducts (6-4PPs)." [PMID:10704216]
synonym: "alternative excision repair, DNA incision" RELATED [PMID:10704216]
synonym: "DNA incision involved in AER" RELATED [PMID:10704216]
synonym: "DNA incision involved in alternative excision repair" RELATED [PMID:10704216]
synonym: "DNA incision involved in UV-damage excision repair" EXACT []
synonym: "DNA incision involved in UV-damaged DNA endonuclease-dependent excision repair" EXACT []
synonym: "DNA incision involved in UVDE-dependent excision repair" EXACT []
synonym: "DNA incision involved in UVER" EXACT []
synonym: "nucleic acid cleavage involved in UV-damage excision repair" EXACT []
synonym: "UV-damaged DNA endonuclease-dependent excision repair, DNA incision" EXACT []
synonym: "UVDE-dependent excision repair, DNA incision" EXACT []
is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis
relationship: part_of GO:0070914 ! UV-damage excision repair
created_by: mah
creation_date: 2015-04-21T15:09:04Z

[Term]
id: GO:1990732
name: pyrenoid
namespace: cellular_component
def: "A non-membrane-bounded organelle found within the chloroplasts of algae and hornworts; responsible for carbon dioxide fixation." [GOC:cjm, http://en.wikipedia.org/wiki/Pyrenoid, PMID:23345319]
xref: http://en.wikipedia.org/wiki/Pyrenoid
is_a: GO:0043228 ! non-membrane-bounded organelle
is_a: GO:0044435 ! plastid part
relationship: part_of GO:0009536 ! plastid
created_by: pr
creation_date: 2015-04-24T12:44:52Z

[Term]
id: GO:1990733
name: titin-telethonin complex
namespace: cellular_component
def: "A protein complex formed between the N-terminus of the giant sarcomeric filament protein titin and the Z-disk ligand, telethonin. The complex is part of the Z-disk of the skeletal and cardiac sarcomere. Telethonin binding to titin might be essential for the initial assembly, stabilization and functional integrity of the titin filament, and hence important for muscle contraction relaxation in mature myofibrils." [GOC:ame, IntAct:EBI-10711453, PMID:16407954]
comment: An example of this are TTN and TCAP in human (UniProt symbols Q8WZ42 and O15273 respectively) in PMID:16407954 (inferred from direct assay).
synonym: "Titin-Tcap complex" RELATED []
is_a: GO:0043234 ! protein complex
is_a: GO:0044449 ! contractile fiber part
relationship: part_of GO:0030018 ! Z disc
created_by: ame
creation_date: 2015-04-24T14:57:08Z

[Term]
id: GO:1990734
name: astral microtubule anchoring at mitotic spindle pole body
namespace: biological_process
def: "Any process in which an astral microtubule is maintained in a specific location in a cell by attachment to a mitotic spindle pole body. Microtubules attach to spindle pole bodies at the minus end." [PMID:15004232]
is_a: GO:0034631 ! microtubule anchoring at spindle pole body
created_by: vw
creation_date: 2015-04-28T12:15:18Z

[Term]
id: GO:1990735
name: gamma-tubulin complex localization to mitotic spindle pole body
namespace: biological_process
def: "Any process in which a gamma-tubulin complex is transported to, or maintained in, a specific location at a mitotic spindle pole body." [GOC:dos, GOC:mah, PMID:11080156]
synonym: "establishment and maintenance of gamma-tubulin complex localization to mitotic spindle pole body" EXACT []
synonym: "gamma-tubulin complex localisation to mitotic spindle pole body" EXACT []
synonym: "gamma-tubulin complex localization to mitotic SPB" EXACT []
is_a: GO:0033566 ! gamma-tubulin complex localization
is_a: GO:1902440 ! protein localization to mitotic spindle pole body
created_by: mah
creation_date: 2015-04-29T14:40:20Z

[Term]
id: GO:1990736
name: regulation of vascular smooth muscle cell membrane depolarization
namespace: biological_process
def: "Any process that modulates the establishment or extent of a membrane potential in the depolarizing direction away from the resting potential in a vascular smooth muscle cell." [PMID:20826763]
is_a: GO:0051899 ! membrane depolarization
created_by: sl
creation_date: 2015-04-29T22:33:19Z

[Term]
id: GO:1990737
name: response to manganese-induced endoplasmic reticulum stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of endoplasmic reticulum stress caused by a manganese stimulus." [GOC:bf, GOC:PARL, PMID:23934647]
synonym: "manganese-induced ER stress response" EXACT [GOC:bf]
synonym: "response to manganese-induced ER stress" EXACT [GOC:bf]
synonym: "response to Mn-induced ER stress" EXACT [PMID:23934647]
is_a: GO:0034976 ! response to endoplasmic reticulum stress
is_a: GO:0071287 ! cellular response to manganese ion
created_by: bf
creation_date: 2015-04-30T13:48:45Z

[Term]
id: GO:1990738
name: pseudouridine 5'-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: pseudouridine 5'-phosphate + H2O = pseudouridine + phosphate." [EC:3.1.3.96, PMID:20722631]
xref: EC:3.1.3.96
is_a: GO:0016791 ! phosphatase activity
created_by: vw
creation_date: 2015-05-02T11:05:50Z

[Term]
id: GO:1990739
name: granulosa cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of granulosa cells, resulting in the expansion of the granulosa cells population. A granulosa cell is a supporting cell for the developing female gamete in the ovary of mammals. They develop from the coelomic epithelial cells of the gonadal ridge." [PMID:22383759]
is_a: GO:0050673 ! epithelial cell proliferation
created_by: sl
creation_date: 2015-05-06T18:56:04Z

[Term]
id: GO:1990740
name: obsolete non-selective anion channel activity
namespace: molecular_function
def: "OBSOLETE. Enables the non-selective, energy-independent passage of anions across a lipid bilayer down a concentration gradient." [GOC:pr, ISBN:0878937420, Wikipedia:Ion_channel#Classification_by_type_of_ions]
comment: This term was made obsolete because it was added in error.
synonym: "nonselective anion channel activity" EXACT []
is_obsolete: true
created_by: pr
creation_date: 2015-05-11T13:25:35Z

[Term]
id: GO:1990741
name: obsolete non-selective cation channel activity
namespace: molecular_function
def: "OBSOLETE. Enables the non-selective, energy-independent passage of cations across a lipid bilayer down a concentration gradient." [GOC:pr, ISBN:0878937420, Wikipedia:Ion_channel#Classification_by_type_of_ions]
comment: This term was made obsolete because it was added in error.
synonym: "nonselective cation channel activity" EXACT []
is_obsolete: true
created_by: pr
creation_date: 2015-05-11T13:27:15Z

[Term]
id: GO:1990742
name: microvesicle
namespace: cellular_component
def: "An extracellular vesicle released from the plasma membrane and ranging in size from about 100 nm to 1000 nm." [GOC:vesicles, PMID:22418571, PMID:24009894, Wikipedia:Microvesicles]
synonym: "ectosome" EXACT [PMID:25683921]
synonym: "extracellular microvesicle" EXACT []
synonym: "shedding vesicle" BROAD []
is_a: GO:1903561 ! extracellular vesicle
created_by: pr
creation_date: 2015-05-13T13:44:52Z

[Term]
id: GO:1990743
name: protein sialylation
namespace: biological_process
def: "A protein modification process that results in the addition of a sialic acid unit to the end of an oligosaccharide chain in a glycoprotein." [PMID:21930713]
is_a: GO:0006464 ! cellular protein modification process
is_a: GO:0097503 ! sialylation
created_by: sl
creation_date: 2015-05-14T20:18:28Z

[Term]
id: GO:1990744
name: primary miRNA methylation
namespace: biological_process
def: "The posttranscriptional addition of methyl groups to specific residues in an primary miRNA molecule." [PMID:25799998]
is_a: GO:0001510 ! RNA methylation
is_a: GO:1990729 ! primary miRNA modification
created_by: sp
creation_date: 2015-05-15T05:18:47Z

[Term]
id: GO:1990745
name: EARP complex
namespace: cellular_component
def: "A quatrefoil tethering complex required for endocytic recycling." [PMID:25799061]
is_a: GO:0043234 ! protein complex
is_a: GO:0044440 ! endosomal part
relationship: part_of GO:0055037 ! recycling endosome
created_by: sp
creation_date: 2015-05-15T10:23:25Z

[Term]
id: GO:1990746
name: HCN4 channel complex
namespace: cellular_component
def: "HCN4 tetramer is a hyperpolarization-activated ion channel with selectivity for potassium over sodium ions. HCN4 is the dominant form of HCN expressed in the heart, together with HCN2. HCN4 expression is particularly high in the sinoatrial node, where impulses initiate and propagate throughout the heart. There is pharmacologic and genetic evidence that the HNC4 channel complex plays a role in cardiac pacemaking and automaticity, by contributing to the native pacemaker current of the heart (If). Mutations in the C-terminus containing the C-linker and CNBD domain, which affect the expression or function of the HCN4 channel are known to cause arrhythmia or bradycardia." [GOC:ame, IntAct:EBI-10814846, PMID:20829353]
comment: An example of this is Hcn4 (Q9Y3Q4) in PMID:20829353 (inferred from direct assay).
synonym: "Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 tetramer" RELATED []
is_a: GO:0098855 ! HCN channel complex
created_by: ame
creation_date: 2015-05-15T13:03:42Z

[Term]
id: GO:1990747
name: pancreatic trypsinogen secretion
namespace: biological_process
def: "The regulated release of trypsinogen from the cells of the exocrine pancreas." [PMID:12771515]
synonym: "pancreatic trypsinogen release" EXACT []
is_a: GO:0009306 ! protein secretion
relationship: part_of GO:0030157 ! pancreatic juice secretion
created_by: sl
creation_date: 2015-05-15T17:41:25Z

[Term]
id: GO:1990748
name: cellular detoxification
namespace: biological_process
def: "Any process carried out at the cellular level that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance." [GOC:vw]
is_a: GO:0009987 ! cellular process
is_a: GO:0098754 ! detoxification
created_by: vw
creation_date: 2015-05-18T16:17:46Z

[Term]
id: GO:1990749
name: polynucleotide adenylyltransferase activator activity
namespace: molecular_function
def: "Increases the activity of the enzyme polynucleotide adenylyltransferase." [GOC:kmv, PMID:19460348]
is_a: GO:0008047 ! enzyme activator activity
created_by: kmv
creation_date: 2015-05-19T15:02:39Z

[Term]
id: GO:1990750
name: obsolete axon shaft
namespace: cellular_component
def: "OBSOLETE. Main portion of an axon, excluding terminal, spines, or dendrites." [PMID:11264310, PMID:24312009]
comment: This term was made obsolete because it was added in error.
synonym: "axonal shaft" EXACT []
is_obsolete: true
consider: GO:0044304
created_by: sl
creation_date: 2015-05-21T17:46:18Z

[Term]
id: GO:1990751
name: Schwann cell chemotaxis
namespace: biological_process
def: "The directed movement of a Schwann cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [PMID:16203995]
is_a: GO:0036135 ! Schwann cell migration
is_a: GO:0060326 ! cell chemotaxis
created_by: sl
creation_date: 2015-05-21T19:19:09Z

[Term]
id: GO:1990752
name: microtubule end
namespace: cellular_component
def: "Any end of a microtubule. Microtubule ends differ in that the so-called microtubule plus-end is the one that preferentially grows by polymerization, with respect to the minus-end." [GOC:pr]
comment: This term should be used when it is not possible to distinguish between the two microtubule ends, e.g. during image annotation. Whenever possible, please annotate to one of the more specific children GO:0035371 'microtubule plus-end' or GO:0036449 'microtubule minus-end'.
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0005874 ! microtubule
created_by: pr
creation_date: 2015-05-25T12:50:31Z

[Term]
id: GO:1990753
name: equatorial cell cortex
namespace: cellular_component
def: "The region of the cell cortex in a mitotically dividing cell that flanks the central spindle and corresponds to the site of actomyosin ring formation that results in cleavage furrow formation and ingression." [PMID:16352658, PMID:22552143, PMID:23750214, PMID:25898168]
xref: GOC:kmv
is_a: GO:0099738 ! cell cortex region
created_by: kmv
creation_date: 2015-05-27T19:12:41Z

[Term]
id: GO:1990754
name: obsolete GABAergic neuronal action potential
namespace: biological_process
def: "OBSOLETE. An action potential that occurs in a GABAergic neuron." [PMID:16921370]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
subset: termgenie_unvetted
synonym: "GABAergic neuronal action potential" EXACT []
is_obsolete: true
created_by: pg
creation_date: 2015-05-28T08:58:42Z

[Term]
id: GO:1990755
name: mitotic spindle microtubule depolymerization
namespace: biological_process
def: "The removal of tubulin heterodimers from one or both ends of a microtubule that is part of the mitotic spindle." [PMID:25253718]
synonym: "mitotic spindle microtubule depolymerisation" EXACT []
is_a: GO:0007019 ! microtubule depolymerization
created_by: mah
creation_date: 2015-05-28T15:42:06Z

[Term]
id: GO:1990756
name: protein binding, bridging involved in substrate recognition for ubiquitination
namespace: molecular_function
def: "The binding activity of a molecule that brings together a ubiquitin ligase and its substrate. Usually mediated by F-box BTB/POZ domain proteins." [PMID:24658274]
is_a: GO:0030674 ! protein binding, bridging
intersection_of: GO:0030674 ! protein binding, bridging
intersection_of: part_of GO:0016567 ! protein ubiquitination
relationship: part_of GO:0016567 ! protein ubiquitination
created_by: vw
creation_date: 2015-06-01T08:35:16Z

[Term]
id: GO:1990757
name: ubiquitin ligase activator activity
namespace: molecular_function
def: "Binds to and increases the activity of a ubiquitin ligase." [PMID:25619242]
is_a: GO:0008047 ! enzyme activator activity
relationship: regulates GO:0061630 ! ubiquitin protein ligase activity
created_by: vw
creation_date: 2015-06-01T08:53:04Z

[Term]
id: GO:1990758
name: mitotic sister chromatid biorientation
namespace: biological_process
def: "The mitotic cell cycle process in which sister chromatids establish stable, end-on attachments to the plus ends of microtubules emanating from opposite spindle poles, oriented such that separation can proceed. This follows metaphase plate congression." [PMID:15309047, PMID:26258632, PMID:26705896]
is_a: GO:0031134 ! sister chromatid biorientation
is_a: GO:0051315 ! attachment of mitotic spindle microtubules to kinetochore
intersection_of: GO:0031134 ! sister chromatid biorientation
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: has_part GO:0051010 ! microtubule plus-end binding
relationship: part_of GO:0000278 ! mitotic cell cycle
created_by: vw
creation_date: 2015-06-02T12:36:17Z

[Term]
id: GO:1990759
name: HCN2 channel complex
namespace: cellular_component
def: "HCN2 is a member of the hyperpolarization-activated ion channel family, which shows selectivity for potassium over sodium ions. Channel gating is facilitated by cAMP binding to the cyclic nucleotide binding domain. HCN2 is the dominant form of HCN expressed in the heart, together with HCN4 (O70507). HCN2 shows significant expression in various regions of the heart, especially the ventricles. There is pharmacological and genetic evidence that HCN channels play a role in cardiac pacemaking and automaticity, by contributing to the native pacemaker current of the heart (If)." [GOC:ame, IntAct:EBI-10825931, PMID:12968185]
comment: An example of this is [Hcn2] in [mouse] (O88703) in PMID:12968185 (inferred from direct assay).
synonym: "Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 tetramer" RELATED []
is_a: GO:0098855 ! HCN channel complex
created_by: ame
creation_date: 2015-06-03T13:49:26Z

[Term]
id: GO:1990760
name: osmolarity-sensing cation channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a cation by a channel that opens when a change in the osmolarity occurs in the extracellular space of the cell in which the cation channel resides." [PMID:18279313]
is_a: GO:0005034 ! osmosensor activity
is_a: GO:0005261 ! cation channel activity
is_a: GO:0022836 ! gated channel activity
created_by: sl
creation_date: 2015-06-05T21:58:50Z

[Term]
id: GO:1990761
name: growth cone lamellipodium
namespace: cellular_component
def: "A thin sheetlike process extended by the leading edge of an axonal or dendritic growth cone; contains a dense meshwork of actin filaments." [GOC:dos, PMID:25598228]
is_a: GO:0030027 ! lamellipodium
is_a: GO:0044463 ! cell projection part
is_a: GO:0097458 ! neuron part
intersection_of: GO:0030027 ! lamellipodium
intersection_of: part_of GO:0030426 ! growth cone
relationship: part_of GO:0030426 ! growth cone
created_by: sl
creation_date: 2015-06-05T22:31:19Z

[Term]
id: GO:1990762
name: cytoplasmic alanyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase involved in cytoplasmic translation." [GOC:vw]
is_a: GO:0006419 ! alanyl-tRNA aminoacylation
relationship: part_of GO:0002181 ! cytoplasmic translation
created_by: vw
creation_date: 2015-06-08T15:56:51Z

[Term]
id: GO:1990763
name: arrestin family protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any member of the arrestin family, proteins involved in agonist-mediated desensitization of G-protein-coupled receptors." [PMID:23911909]
is_a: GO:0005515 ! protein binding
created_by: sl
creation_date: 2015-06-09T23:29:42Z

[Term]
id: GO:1990764
name: myofibroblast contraction
namespace: biological_process
def: "The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of a myofibroblast." [PMID:19239477]
synonym: "MF contraction" EXACT []
synonym: "MFB contraction" EXACT []
is_a: GO:0070252 ! actin-mediated cell contraction
created_by: sl
creation_date: 2015-06-09T23:43:09Z

[Term]
id: GO:1990765
name: colon smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry of the large intestine, exclusive of the rectum. The colon is that part of the large intestine that connects the small intestine to the rectum." [PMID:24170253]
is_a: GO:0006939 ! smooth muscle contraction
relationship: part_of GO:0014827 ! intestine smooth muscle contraction
created_by: sl
creation_date: 2015-06-10T18:29:21Z

[Term]
id: GO:1990767
name: prostaglandin receptor internalization
namespace: biological_process
def: "The process that results in the uptake of a prostaglandin receptor into an endocytic vesicle." [PMID:15937517]
is_a: GO:0002031 ! G-protein coupled receptor internalization
created_by: sl
creation_date: 2015-06-10T19:14:08Z

[Term]
id: GO:1990768
name: gastric mucosal blood circulation
namespace: biological_process
def: "The flow of blood through the gastric mucosa of an animal, enabling the transport of nutrients and the removal of waste products." [PMID:10807413]
synonym: "stomach mucosal blood circulation" EXACT []
is_a: GO:0008015 ! blood circulation
created_by: sl
creation_date: 2015-06-10T20:11:09Z

[Term]
id: GO:1990769
name: proximal neuron projection
namespace: cellular_component
def: "The portion of an axon or dendrite that is close to the neuronal cell body." [PMID:21104189]
is_a: GO:0043005 ! neuron projection
created_by: sl
creation_date: 2015-06-10T20:30:40Z

[Term]
id: GO:1990770
name: small intestine smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry in the intestine between the stomach and the large intestine." [PMID:11991626]
is_a: GO:0006939 ! smooth muscle contraction
relationship: part_of GO:0014827 ! intestine smooth muscle contraction
created_by: sl
creation_date: 2015-06-11T18:02:33Z

[Term]
id: GO:1990771
name: clathrin-mediated extracellular exosome endocytosis
namespace: biological_process
def: "The clathrin-mediated endocytosis of an extracellular exosome." [PMID:24951588]
synonym: "exosome related" EXACT []
is_a: GO:0051650 ! establishment of vesicle localization
is_a: GO:0072583 ! clathrin-mediated endocytosis
created_by: sl
creation_date: 2015-06-15T17:03:57Z

[Term]
id: GO:1990772
name: substance P secretion
namespace: biological_process
def: "The regulated release of substance P, a peptide hormone that is involved in neurotransmission, inflammation, and antimicrobial activity." [PMID:11278900]
is_a: GO:0030072 ! peptide hormone secretion
created_by: sl
creation_date: 2015-06-15T18:17:30Z

[Term]
id: GO:1990773
name: matrix metallopeptidase secretion
namespace: biological_process
def: "The regulated release of matrix metallopeptidases, a family of zinc-dependent endopeptidases that can degrade extracellular matrix proteins and process other types of proteins." [PMID:8679543]
synonym: "matrix metalloproteinase secretion" NARROW []
synonym: "MMP secretion" EXACT []
is_a: GO:0009306 ! protein secretion
created_by: sl
creation_date: 2015-06-15T19:12:06Z

[Term]
id: GO:1990774
name: tumor necrosis factor secretion
namespace: biological_process
def: "The regulated release of tumor necrosis factor from a cell. Tumor necrosis factor is an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis." [PMID:15560120]
synonym: "cachectin secretion" EXACT []
synonym: "TNF secretion" EXACT []
synonym: "TNF superfamily, member 2 secretion" EXACT []
synonym: "TNF-alpha secretion" EXACT []
synonym: "Tnfa secretion" EXACT []
synonym: "tumor necrosis factor alpha secretion" EXACT []
synonym: "tumor necrosis factor ligand superfamily member 2 secretion" EXACT []
is_a: GO:0050663 ! cytokine secretion
relationship: part_of GO:0032640 ! tumor necrosis factor production
created_by: sl
creation_date: 2015-06-15T22:59:26Z

[Term]
id: GO:1990775
name: endothelin secretion
namespace: biological_process
def: "The regulated release of endothelin from a cell. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions." [PMID:15560120]
synonym: "EDN1 secretion" NARROW []
synonym: "EDN2 secretion" NARROW []
synonym: "EDN3 secretion" NARROW []
synonym: "endothelin-1 secretion" NARROW []
synonym: "endothelin-2 secretion" NARROW []
synonym: "endothelin-3 secretion" NARROW []
is_a: GO:0050663 ! cytokine secretion
created_by: sl
creation_date: 2015-06-15T23:13:18Z

[Term]
id: GO:1990776
name: response to angiotensin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an angiotensin stimulus. Angiotensin is any of three physiologically active peptides (angiotensin II, III, or IV) processed from angiotensinogen." [PMID:22982863]
is_a: GO:0043434 ! response to peptide hormone
created_by: sl
creation_date: 2015-06-16T17:41:17Z

[Term]
id: GO:1990777
name: lipoprotein particle
namespace: cellular_component
def: "A spherical particle containing non-covalently associated proteins and lipids. Examples are plasma lipoprotein particles which transport lipids in the blood or lymph." [GOC:vesicles]
is_a: GO:0032994 ! protein-lipid complex
created_by: pr
creation_date: 2015-06-18T08:42:53Z

[Term]
id: GO:1990778
name: protein localization to cell periphery
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, the cell periphery." [PMID:18216290]
is_a: GO:0034613 ! cellular protein localization
creation_date: 2015-06-18T22:37:39Z

[Term]
id: GO:1990779
name: glycoprotein Ib-IX-V complex
namespace: cellular_component
def: "A transmembrane signalling receptor complex found exclusively on platelets. Involved in haemostasis and thrombosis where it aids blood coagulation." [GOC:bhm, IntAct:EBI-10727454, IntAct:EBI-10728062, PMID:1730602, PMID:23336709, PMID:25297919]
comment: An example of this is GB1BA in human (P07359) in PMID:1730602 (inferred from direct assay).
synonym: "CD42" EXACT []
synonym: "GPIb-IX-V complex" EXACT []
synonym: "GPIb-V-IX complex" EXACT []
is_a: GO:0090665 ! glycoprotein complex
is_a: GO:0098802 ! plasma membrane receptor complex
relationship: part_of GO:0005887 ! integral component of plasma membrane
created_by: bhm
creation_date: 2015-06-23T11:22:12Z

[Term]
id: GO:1990780
name: cytoplasmic side of dendritic spine plasma membrane
namespace: cellular_component
def: "The leaflet of the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface surrounding a dendritic spine." [PMID:9275233]
is_a: GO:0009898 ! cytoplasmic side of plasma membrane
is_a: GO:0044456 ! synapse part
is_a: GO:0044463 ! cell projection part
is_a: GO:0097458 ! neuron part
relationship: part_of GO:0032591 ! dendritic spine membrane
created_by: sl
creation_date: 2015-06-23T18:35:39Z

[Term]
id: GO:1990781
name: response to immobilization stress combined with electrical stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus given while being held immobile." [PMID:17008368]
is_a: GO:0035902 ! response to immobilization stress
is_a: GO:0051602 ! response to electrical stimulus
created_by: sl
creation_date: 2015-06-23T20:30:42Z

[Term]
id: GO:1990782
name: protein tyrosine kinase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with protein tyrosine kinase." [PMID:25499537]
synonym: "tyrosine kinase binding" EXACT []
is_a: GO:0019901 ! protein kinase binding
created_by: sl
creation_date: 2015-06-23T20:50:58Z

[Term]
id: GO:1990783
name: periphagosomal region of cytoplasm
namespace: cellular_component
def: "Cytoplasm situated near, or occurring around, a phagosome." [PMID:18250451]
is_a: GO:0044444 ! cytoplasmic part
created_by: sl
creation_date: 2015-06-23T21:46:10Z

[Term]
id: GO:1990784
name: response to dsDNA
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded DNA stimulus." [PMID:10051633]
synonym: "response to double-stranded DNA" EXACT []
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901698 ! response to nitrogen compound
created_by: sl
creation_date: 2015-06-24T17:54:13Z

[Term]
id: GO:1990785
name: response to water-immersion restraint stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of water immersion while being held immobile." [PMID:10882227]
synonym: "response to immobilization stress combined with water immersion" EXACT []
is_a: GO:0035902 ! response to immobilization stress
created_by: sl
creation_date: 2015-06-24T18:27:28Z

[Term]
id: GO:1990786
name: cellular response to dsDNA
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded DNA stimulus." [PMID:10051633]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1990784 ! response to dsDNA
created_by: sl
creation_date: 2015-06-24T22:48:25Z

[Term]
id: GO:1990787
name: negative regulation of hh target transcription factor activity
namespace: biological_process
def: "Any process that decreases the activity of a transcription factor that activates transcription of Hedgehog-target genes in response to Smoothened signaling. In Drosophila, Cubitus interruptus (Ci) is the only identified transcription factor so far in the Hedgehog signaling pathway. In vertebrates members of the Gli protein family are activated by Hedgehog signaling." [GOC:bhm, IntAct:EBI-10170144, PMID:24311597]
synonym: "negative regulation of hedgehog target transcription factor" EXACT []
is_a: GO:0045879 ! negative regulation of smoothened signaling pathway
is_a: GO:0051090 ! regulation of sequence-specific DNA binding transcription factor activity
created_by: bhm
creation_date: 2015-06-26T09:54:29Z

[Term]
id: GO:1990788
name: GLI-SUFU complex
namespace: cellular_component
def: "A protein repressing GLI's transcription factor activity when SMO signalling is inactive. Upon ligand binding to the upstream receptor PTC (Patched) GLI dissociates from SUFU and activates transcription of hedgehog-target genes. In mammals it consists of SUFU and one of the GLI family proteins." [GOC:bhm, IntAct:EBI-10170144, IntAct:EBI-10828915, IntAct:EBI-10828948, IntAct:EBI-10828976, IntAct:EBI-10828997, IntAct:EBI-10829035, PMID:24311597]
comment: An example of this is SUFU in human (Q9UMX1) in PMID:24311597 (inferred from direct assay).
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part
relationship: part_of GO:0005829 ! cytosol
created_by: bhm
creation_date: 2015-06-26T13:49:47Z

[Term]
id: GO:1990789
name: thyroid gland epithelial cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of thyroid gland epithelial cells, resulting in the expansion of the thyroid gland epithelial cell population." [PMID:17646383]
synonym: "Hurthle cell proliferation" NARROW []
synonym: "thyroid follicular cell proliferation" NARROW []
is_a: GO:0050673 ! epithelial cell proliferation
relationship: part_of GO:0030878 ! thyroid gland development
created_by: sl
creation_date: 2015-07-02T18:50:01Z

[Term]
id: GO:1990790
name: response to glial cell derived neurotrophic factor
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glial cell derived neurotrophic factor stimulus." [PMID:20877310]
synonym: "response to astrocyte-derived trophic factor" EXACT []
synonym: "response to ATF" EXACT []
synonym: "response to GDNF" EXACT []
is_a: GO:0009719 ! response to endogenous stimulus
is_a: GO:0070848 ! response to growth factor
created_by: sl
creation_date: 2015-07-02T19:47:05Z

[Term]
id: GO:1990791
name: dorsal root ganglion development
namespace: biological_process
def: "The process whose specific outcome is the progression of a dorsal root ganglion over time, from its formation to the mature structure." [PMID:18583150]
synonym: "DRG development" EXACT []
is_a: GO:0061548 ! ganglion development
created_by: sl
creation_date: 2015-07-02T22:09:54Z

[Term]
id: GO:1990792
name: cellular response to glial cell derived neurotrophic factor
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glial cell derived neurotrophic factor stimulus." [PMID:20877310]
synonym: "cellular response to astrocyte-derived trophic factor" EXACT []
synonym: "cellular response to ATF" EXACT []
synonym: "cellular response to GDNF" EXACT []
is_a: GO:0071363 ! cellular response to growth factor stimulus
is_a: GO:0071495 ! cellular response to endogenous stimulus
is_a: GO:1990790 ! response to glial cell derived neurotrophic factor
created_by: sl
creation_date: 2015-07-06T15:27:38Z

[Term]
id: GO:1990793
name: substance P secretion, neurotransmission
namespace: biological_process
def: "The controlled release of substance P by a cell, in which the substance P acts as a neurotransmitter." [PMID:15292051]
is_a: GO:0007269 ! neurotransmitter secretion
is_a: GO:1990772 ! substance P secretion
created_by: sl
creation_date: 2015-07-09T19:43:36Z

[Term]
id: GO:1990794
name: basolateral part of cell
namespace: cellular_component
def: "The region of a cell situated by the cell sides which interface adjacent cells and near the base. Often used in reference to animal polarized epithelial cells." [PMID:18495799]
is_a: GO:0044464 ! cell part
relationship: part_of GO:0045178 ! basal part of cell
relationship: part_of GO:0097574 ! lateral part of cell
created_by: sl
creation_date: 2015-07-09T20:31:50Z

[Term]
id: GO:1990795
name: rod bipolar cell terminal bouton
namespace: cellular_component
def: "A specialized region of the axon terminus portion of a rod bipolar axon. A rod bipolar cell is a neuron found in the retina and having connections with rod photoreceptor cells and neurons in the inner plexiform layer." [PMID:19883736]
is_a: GO:0043195 ! terminal bouton
created_by: sl
creation_date: 2015-07-09T21:11:53Z

[Term]
id: GO:1990796
name: photoreceptor cell terminal bouton
namespace: cellular_component
def: "A specialized region of the axon terminus portion of a photoreceptor cell axon. A photoreceptor cell is a neuron specialized to detect and transduce light." [PMID:19883736]
is_a: GO:0043195 ! terminal bouton
created_by: sl
creation_date: 2015-07-09T21:33:40Z

[Term]
id: GO:1990797
name: obsolete cholecystokinin secretion
namespace: biological_process
def: "OBSOLETE. The controlled release of cholecystokinin from a cell. Cholecystokinin is a peptide hormone that participates in pancreatic enzyme release in the gut and is also found in the brain." [PMID:2755938]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
subset: termgenie_unvetted
synonym: "CCK secretion" EXACT []
is_obsolete: true
created_by: sl
creation_date: 2015-07-09T23:14:23Z

[Term]
id: GO:1990798
name: pancreas regeneration
namespace: biological_process
def: "The regrowth of a destroyed pancreas." [PMID:1985964]
is_a: GO:0031100 ! organ regeneration
created_by: sl
creation_date: 2015-07-10T22:53:53Z

[Term]
id: GO:1990799
name: mitochondrial tRNA wobble position uridine thiolation
namespace: biological_process
def: "The process in which a uridine residue at position 34 in the anticodon of a mitochondrial tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps." [PMID:15509579]
is_a: GO:0002143 ! tRNA wobble position uridine thiolation
is_a: GO:0070899 ! mitochondrial tRNA wobble uridine modification
is_a: GO:0070903 ! mitochondrial tRNA thio-modification
created_by: vw
creation_date: 2015-07-13T08:15:15Z

[Term]
id: GO:1990801
name: protein phosphorylation involved in mitotic spindle assembly
namespace: biological_process
def: "Any protein phosphorylation that is involved in mitotic spindle assembly." [GO_REF:0000060, GOC:rb, GOC:TermGenie, PMID:21558801]
comment: An example of this is yeast Cdc28p which involved in the phosphorylation of Ase1p which is required for correct spindle assembly in PMID:21558801 by IGI (Cdc28 with Clb5).
synonym: "protein amino acid phosphorylation involved in mitotic spindle assembly" EXACT []
synonym: "protein amino acid phosphorylation involved in spindle assembly involved in mitosis" EXACT []
synonym: "protein phosphorylation involved in spindle assembly involved in mitosis" EXACT []
is_a: GO:0006468 ! protein phosphorylation
is_a: GO:0044710 ! single-organism metabolic process
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0006468 ! protein phosphorylation
intersection_of: part_of GO:0090307 ! mitotic spindle assembly
relationship: part_of GO:0090307 ! mitotic spindle assembly
created_by: rb
creation_date: 2015-07-16T18:36:05Z

[Term]
id: GO:1990802
name: protein phosphorylation involved in DNA double-strand break processing
namespace: biological_process
def: "Any protein phosphorylation that is required for DNA double-strand break processing." [GO_REF:0000060, GOC:rb, GOC:TermGenie, PMID:21841787]
comment: An example of this is the yeast Cdc28 that phosphorylates Dna2 (IMP) as shown in PMID:21841787.
synonym: "protein amino acid phosphorylation involved in DNA double-strand break processing" EXACT []
is_a: GO:0006468 ! protein phosphorylation
intersection_of: GO:0006468 ! protein phosphorylation
intersection_of: part_of GO:0000729 ! DNA double-strand break processing
relationship: part_of GO:0000729 ! DNA double-strand break processing
created_by: rb
creation_date: 2015-07-16T20:43:39Z

[Term]
id: GO:1990803
name: protein phosphorylation involved in protein localization to spindle microtubule
namespace: biological_process
def: "Any protein phosphorylation process involved in localizing a protein to the spindle microtubule." [GO_REF:0000060, GOC:rb, GOC:TermGenie, PMID:22521784]
comment: An example of this is yeast Cdc28. It phosphorylates Ipl1 to localize it to spindle microtubule.
synonym: "protein amino acid phosphorylation involved in protein localisation in spindle microtubule" EXACT []
synonym: "protein amino acid phosphorylation involved in protein localisation to spindle microtubule" EXACT []
synonym: "protein amino acid phosphorylation involved in protein localization in spindle microtubule" EXACT []
synonym: "protein amino acid phosphorylation involved in protein localization to spindle microtubule" EXACT []
synonym: "protein phosphorylation involved in protein localisation in spindle microtubule" EXACT []
synonym: "protein phosphorylation involved in protein localisation to spindle microtubule" EXACT []
synonym: "protein phosphorylation involved in protein localization in spindle microtubule" EXACT []
is_a: GO:0006468 ! protein phosphorylation
intersection_of: GO:0006468 ! protein phosphorylation
intersection_of: part_of GO:1902889 ! protein localization to spindle microtubule
relationship: part_of GO:1902889 ! protein localization to spindle microtubule
created_by: rb
creation_date: 2015-07-16T21:09:07Z

[Term]
id: GO:1990804
name: protein phosphorylation involved in double-strand break repair via nonhomologous end joining
namespace: biological_process
def: "Any protein phosphorylation process that is required for double-strand break repair via nonhomologous end joining." [GO_REF:0000060, GOC:rb, GOC:TermGenie, PMID:22563681]
comment: An example of this is the phosphorylation of yeast LIF1 by CDC28 during G2/M phase (IMP,PMID:22563681).
synonym: "protein amino acid phosphorylation involved in double-strand break repair via nonhomologous end joining" EXACT []
synonym: "protein amino acid phosphorylation involved in NHEJ" EXACT []
synonym: "protein phosphorylation involved in NHEJ" EXACT []
is_a: GO:0006468 ! protein phosphorylation
intersection_of: GO:0006468 ! protein phosphorylation
intersection_of: part_of GO:0006303 ! double-strand break repair via nonhomologous end joining
relationship: part_of GO:0006303 ! double-strand break repair via nonhomologous end joining
created_by: rb
creation_date: 2015-07-16T21:54:01Z

[Term]
id: GO:1990805
name: central cylinder
namespace: cellular_component
def: "A scaffolding structure present within the inner region of the ciliary transition zone. The central cylinder lies between the outer doublet and inner singlet microtubules." [GOC:kmv, PMID:2428682, PMID:26124290]
is_a: GO:0044441 ! ciliary part
relationship: part_of GO:0035869 ! ciliary transition zone
created_by: kmv
creation_date: 2015-07-17T17:48:17Z

[Term]
id: GO:1990806
name: obsolete ligand-gated ion channel signaling pathway
namespace: biological_process
def: "OBSOLETE. A series of molecular signals initiated by activation of a ligand-gated ion channel on the surface of a cell. The pathway begins with binding of an extracellular ligand to a ligand-gated ion channel and ends with a molecular function that directly regulates a downstream cellular process, e.g. transcription." [GOC:bhm, PMID:25869137]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
subset: termgenie_unvetted
synonym: "ligand-gated ion channel signalling pathway" EXACT []
is_obsolete: true
created_by: bhm
creation_date: 2015-07-20T12:09:56Z

[Term]
id: GO:1990807
name: obsolete protein N-acetyltransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the transfer of an acetyl group to a nitrogen atom on the amino acid of a protein." [GOC:dph]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
subset: termgenie_unvetted
is_obsolete: true
created_by: vw
creation_date: 2015-07-20T15:19:23Z

[Term]
id: GO:1990808
name: F-bar domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an F-BAR domain of a protein, a domain of about 60 residues that occurs in a wide range of cytoskeletal proteins." [PMID:20603077]
is_a: GO:0019904 ! protein domain specific binding
created_by: vw
creation_date: 2015-07-21T18:43:00Z

[Term]
id: GO:1990809
name: endoplasmic reticulum tubular network membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER) tubular network membrane." [PMID:20434336]
is_a: GO:0071786 ! endoplasmic reticulum tubular network organization
is_a: GO:0090158 ! endoplasmic reticulum membrane organization
is_a: GO:1902589 ! single-organism organelle organization
created_by: vw
creation_date: 2015-07-22T16:42:36Z

[Term]
id: GO:1990810
name: microtubule anchoring at mitotic spindle pole body
namespace: biological_process
def: "Any process in which a microtubule is maintained in a specific location in a cell by attachment to a mitotic spindle pole body. Microtubules attach to spindle pole bodies at the minus end." [PMID:17486116]
is_a: GO:0034631 ! microtubule anchoring at spindle pole body
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:0007052 ! mitotic spindle organization
created_by: vw
creation_date: 2015-07-24T12:52:25Z

[Term]
id: GO:1990811
name: Msd1-Wdr8-Pkl1 complex
namespace: cellular_component
def: "A protein ternary complex that anchors microtubule minus ends to mitotic spindle pole bodies. The founding complex contains a microtubule anchoring protein (Msd1 in fission yeast), A WD-repeat Wdr8 family protein and and a minus end-directed kinesin." [PMID:25987607]
is_a: GO:0043234 ! protein complex
created_by: vw
creation_date: 2015-07-24T13:34:31Z

[Term]
id: GO:1990812
name: growth cone filopodium
namespace: cellular_component
def: "A thin, stiff protrusion extended by the leading edge of an axonal or dendritic growth cone." [PMID:25598228]
is_a: GO:0030175 ! filopodium
is_a: GO:0044463 ! cell projection part
is_a: GO:0097458 ! neuron part
relationship: part_of GO:0030426 ! growth cone
created_by: sl
creation_date: 2015-07-24T22:35:16Z

[Term]
id: GO:1990813
name: meiotic centromeric cohesion protection
namespace: biological_process
def: "The process in which the association between sister chromatids of a replicated chromosome centromeric region is maintained during homologous chromosome segregation after cohesin is cleaved by separase along the arm regions." [PMID:14730319, PMID:25533956]
is_a: GO:0035875 ! maintenance of meiotic sister chromatid cohesion, centromeric
created_by: vw
creation_date: 2015-07-28T16:15:31Z

[Term]
id: GO:1990814
name: DNA/DNA annealing activity
namespace: molecular_function
def: "A nucleic acid binding activity that brings together complementary sequences of ssDNA so that they pair by hydrogen bonds to form a double-stranded DNA." [PMID:25520186]
is_a: GO:0097617 ! annealing activity
created_by: vw
creation_date: 2015-07-29T12:35:03Z

[Term]
id: GO:1990815
name: obsolete regulation of protein localization to cell division site after cytokinesis
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of protein localization to cell division site involved in cell separation after cytokinesis." [PMID:25411334]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
subset: termgenie_unvetted
is_obsolete: true
created_by: vw
creation_date: 2015-07-29T14:03:34Z

[Term]
id: GO:1990816
name: vacuole-mitochondrion membrane contact site
namespace: cellular_component
def: "A zone of apposition between the vacuolar membrane and the mitochondrial outer membrane, important for transfer of lipids between the two organelles." [PMID:25026035, PMID:25026036]
synonym: "vacuole and mitochondria patch" EXACT []
synonym: "vCLAMP" EXACT []
is_a: GO:0044232 ! organelle membrane contact site
created_by: mcc
creation_date: 2015-07-29T21:06:41Z

[Term]
id: GO:1990817
name: RNA adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the template-independent extension of the 3'- end of an RNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA, or oligo(A) bearing a 3'-OH terminal group." [GOC:vw]
is_a: GO:0004652 ! polynucleotide adenylyltransferase activity
created_by: vw
creation_date: 2015-07-31T09:38:31Z

[Term]
id: GO:1990818
name: L-arginine transmembrane export from vacuole
namespace: biological_process
def: "The directed movement of L-arginine out of the vacuole, across the vacuolar membrane." [PMID:26083598]
is_a: GO:0034488 ! basic amino acid transmembrane export from vacuole
is_a: GO:1903400 ! L-arginine transmembrane transport
created_by: vw
creation_date: 2015-08-06T15:06:33Z

[Term]
id: GO:1990819
name: actin fusion focus
namespace: cellular_component
def: "A focus at the mating projection tip where the cell wall is degraded during conjugation with cellular fusion. Actin filaments form an aster-like structure from this location." [PMID:25825517]
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044463 ! cell projection part
relationship: has_part GO:0005884 ! actin filament
relationship: part_of GO:0015629 ! actin cytoskeleton
relationship: part_of GO:0043332 ! mating projection tip
created_by: al
creation_date: 2015-08-10T16:52:15Z

[Term]
id: GO:1990820
name: response to mitotic DNA integrity checkpoint signaling
namespace: biological_process
def: "A process that occurs in response to signals generated as a result of mitotic DNA integrity checkpoint signaling." [PMID:7548844]
synonym: "response to signal involved in mitotic DNA integrity checkpoint" EXACT []
is_a: GO:0072402 ! response to DNA integrity checkpoint signaling
is_a: GO:0072414 ! response to mitotic cell cycle checkpoint signaling
created_by: mah
creation_date: 2015-08-14T10:25:46Z

[Term]
id: GO:1990821
name: high affinity glucose import
namespace: biological_process
def: "The directed, high-affinity movement of glucose into a cell by means of some agent such as a transporter or pore. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [PMID:25411338]
is_a: GO:0008646 ! high-affinity hexose transport
is_a: GO:0098708 ! glucose import across plasma membrane
created_by: al
creation_date: 2015-08-18T10:27:45Z

[Term]
id: GO:1990822
name: basic amino acid transmembrane transport
namespace: biological_process
def: "The directed movement of basic amino acids from one side of a membrane to the other." [GOC:dph, GOC:vw]
is_a: GO:0015802 ! basic amino acid transport
is_a: GO:0098656 ! anion transmembrane transport
is_a: GO:1903825 ! organic acid transmembrane transport
created_by: vw
creation_date: 2015-08-19T07:47:00Z

[Term]
id: GO:1990823
name: response to leukemia inhibitory factor
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus." [PMID:12801913]
synonym: "response to CDF" EXACT []
synonym: "response to cholinergic differentiation factor" EXACT []
synonym: "response to LIF" EXACT []
is_a: GO:0034097 ! response to cytokine
created_by: sl
creation_date: 2015-08-19T16:44:21Z

[Term]
id: GO:1990824
name: obsolete magnesium-dependent protein complex
namespace: cellular_component
def: "OBSOLETE. A protein complex that depends on magnesium in order for one or more of its components to remain a part of the complex." [PMID:10220587]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
subset: termgenie_unvetted
is_obsolete: true
created_by: sl
creation_date: 2015-08-19T17:11:43Z

[Term]
id: GO:1990825
name: sequence-specific mRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with messenger RNA (mRNA) of a specific nucleotide composition or a specific sequence motif." [PMID:11886857]
is_a: GO:0003729 ! mRNA binding
created_by: sl
creation_date: 2015-08-19T17:42:50Z

[Term]
id: GO:1990826
name: nucleoplasmic periphery of the nuclear pore complex
namespace: cellular_component
def: "Nucleoplasm situated in close proximity and peripheral to a nuclear pore complex." [PMID:10633080]
is_a: GO:0044451 ! nucleoplasm part
created_by: sl
creation_date: 2015-08-19T18:26:26Z

[Term]
id: GO:1990827
name: deaminase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an enzyme that catalyzes the removal of an amino group from a substrate, producing ammonia (NH3)." [PMID:9792439]
is_a: GO:0019899 ! enzyme binding
created_by: sl
creation_date: 2015-08-19T23:48:32Z

[Term]
id: GO:1990828
name: hepatocyte dedifferentiation
namespace: biological_process
def: "The process in which a hepatocyte (specialized epithelial cell of the liver) loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors." [PMID:20102719]
is_a: GO:0043697 ! cell dedifferentiation
created_by: sl
creation_date: 2015-08-20T14:14:57Z

[Term]
id: GO:1990829
name: C-rich single-stranded DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with C-rich, single-stranded DNA." [PMID:8127654]
synonym: "C-rich ssDNA binding" EXACT []
is_a: GO:0003697 ! single-stranded DNA binding
created_by: sl
creation_date: 2015-08-20T16:05:12Z

[Term]
id: GO:1990830
name: cellular response to leukemia inhibitory factor
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus." [PMID:12801913]
synonym: "cellular response to CDF" EXACT []
synonym: "cellular response to cholinergic differentiation factor" EXACT []
is_a: GO:0071345 ! cellular response to cytokine stimulus
is_a: GO:1990823 ! response to leukemia inhibitory factor
created_by: sl
creation_date: 2015-08-20T19:30:38Z

[Term]
id: GO:1990831
name: cellular response to carcinoembryonic antigen
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carcinoembryonic antigen stimulus. The carcinoembryonic antigens represent a family of glycoproteins" [PMID:10202129, PMID:14597422]
synonym: "cellular response to pregnancy specific glycoprotein" EXACT []
is_a: GO:1904588 ! cellular response to glycoprotein
created_by: sl
creation_date: 2015-08-20T19:43:12Z

[Term]
id: GO:1990832
name: slow axonal transport
namespace: biological_process
def: "The directed slow movement of non-membranous molecules in nerve cell axons. It is comprised of a \"slow component a\" (SCa) and a \"slow component b\" (SCb) which differ in transport rates and protein composition." [PMID:6378920]
is_a: GO:0008088 ! axo-dendritic transport
created_by: sl
creation_date: 2015-08-21T17:27:32Z

[Term]
id: GO:1990833
name: clathrin-uncoating ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the removal of clathrin from vesicle membranes, coupled to the hydrolysis of ATP." [PMID:6146630, PMID:8363588]
is_a: GO:0042623 ! ATPase activity, coupled
relationship: part_of GO:0072318 ! clathrin coat disassembly
created_by: sl
creation_date: 2015-08-21T18:01:42Z

[Term]
id: GO:1990834
name: response to odorant
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an odorant stimulus. An odorant is any substance capable of stimulating the sense of smell." [PMID:11268007]
is_a: GO:0042221 ! response to chemical
created_by: sl
creation_date: 2015-08-21T18:51:52Z

[Term]
id: GO:1990835
name: obsolete insulin-like growth factor production
namespace: biological_process
def: "OBSOLETE. The appearance of an insulin-like growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [PMID:21993393]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
subset: termgenie_unvetted
synonym: "IGF production" RELATED []
is_obsolete: true
created_by: sl
creation_date: 2015-08-24T16:30:53Z

[Term]
id: GO:1990836
name: lysosomal matrix
namespace: cellular_component
def: "A matrix composed of supramolecular assemblies of lysosomal enzymes and lipids which forms at a pH of 5.0 within the lysosome." [PMID:9395337]
is_a: GO:0044437 ! vacuolar part
relationship: part_of GO:0043202 ! lysosomal lumen
created_by: sl
creation_date: 2015-08-25T17:04:12Z

[Term]
id: GO:1990837
name: sequence-specific double-stranded DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding." [GOC:dos, GOC:sl]
synonym: "sequence-specific dsDNA binding" EXACT []
is_a: GO:0003690 ! double-stranded DNA binding
is_a: GO:0043565 ! sequence-specific DNA binding
created_by: sl
creation_date: 2015-08-25T17:30:06Z

[Term]
id: GO:1990838
name: poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends
namespace: molecular_function
def: "Catalysis of 3' exonucleolytic cleavage of poly(U), to form poly(U)-N containing a 3' uridine cyclic phosphate (U>P)." [PMID:23022480]
is_a: GO:0000175 ! 3'-5'-exoribonuclease activity
created_by: al
creation_date: 2015-08-26T10:24:51Z

[Term]
id: GO:1990839
name: response to endothelin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an endothelin stimulus. Endothelin is any of three secretory vasoconstrictive peptides (endothelin-1, -2, -3)." [PMID:16365184]
is_a: GO:0043434 ! response to peptide hormone
created_by: sl
creation_date: 2015-08-27T19:37:52Z

[Term]
id: GO:1990840
name: response to lectin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lectin stimulus. A lectin is a carbohydrate-binding protein, highly specific for binding sugar moieties." [PMID:25996210, PMID:26306444]
comment: This term refers to endogenous (evolved) responses to lectins (endogenous or exogenous), it does not cover the events that happen due to lectin toxicity.
is_a: GO:0009607 ! response to biotic stimulus
created_by: sl
creation_date: 2015-08-27T20:02:21Z

[Term]
id: GO:1990841
name: promoter-specific chromatin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a section of chromatin that is associated with gene promoter sequences of DNA." [PMID:19948729]
is_a: GO:0003682 ! chromatin binding
created_by: sl
creation_date: 2015-08-28T14:48:29Z

[Term]
id: GO:1990842
name: obsolete response to prenatal stress
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis in the embryo or fetus during pregnancy." [PMID:22738222]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
subset: termgenie_unvetted
synonym: "response to PNS" EXACT []
is_obsolete: true
created_by: sl
creation_date: 2015-08-31T15:15:29Z

[Term]
id: GO:1990843
name: subsarcolemmal mitochondrion
namespace: cellular_component
def: "A mitochondrion that occurs adjacent to the sarcolemma in striated muscle cells and responds in distinct ways to physiological triggers." [PMID:23297307, PMID:26039174]
synonym: "SS mitochondrion" EXACT []
synonym: "SSM" EXACT []
is_a: GO:0005739 ! mitochondrion
created_by: sl
creation_date: 2015-08-31T16:05:14Z

[Term]
id: GO:1990844
name: interfibrillar mitochondrion
namespace: cellular_component
def: "A mitochondrion that occurs in between fibrils of striated muscle cells and responds in distinct ways to physiological triggers." [PMID:23297307, PMID:26039174]
synonym: "IFM" EXACT []
synonym: "IMF mitochondrion" EXACT []
synonym: "intermyofibrillar mitochondrion" EXACT []
is_a: GO:0005739 ! mitochondrion
created_by: sl
creation_date: 2015-08-31T16:26:44Z

[Term]
id: GO:1990845
name: adaptive thermogenesis
namespace: biological_process
def: "The regulated production of heat in response to short term environmental changes, such as stress, diet or reduced temperature." [PMID:17260010, PMID:20363363]
is_a: GO:0044236 ! multicellular organism metabolic process
created_by: sl
creation_date: 2015-08-31T18:19:49Z

[Term]
id: GO:1990846
name: ribonucleoside-diphosphate reductase inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents or reduces the activity of ribonucleoside-diphosphate reductase." [PMID:16317005]
is_a: GO:0004857 ! enzyme inhibitor activity
created_by: vw
creation_date: 2015-09-04T18:13:15Z

[Term]
id: GO:1990847
name: peptide pheromone transmembrane export involved in conjugation with cellular fusion
namespace: biological_process
def: "The directed movement of a peptide pheromone across a membrane and out of a cell by a secretion or export pathway used solely for the export of peptide pheromones that contributes to a conjugation process that results in the union of cellular and genetic information from compatible mating types." [PMID:9236781]
is_a: GO:0071833 ! peptide pheromone export involved in conjugation with cellular fusion
is_a: GO:0090539 ! peptide pheromone export by transmembrane transport
created_by: al
creation_date: 2015-09-08T15:23:26Z

[Term]
id: GO:1990848
name: obsolete Positive regulation of removal of reactive oxygen species
namespace: biological_process
def: "OBSOLETE. Any process that increases the frequency, rate or extent of removal of reactive oxygen species in a cell." [PMID:24118096]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
subset: termgenie_unvetted
is_obsolete: true
created_by: al
creation_date: 2015-09-09T11:59:57Z

[Term]
id: GO:1990849
name: maintenance of vacuolar location
namespace: biological_process
def: "Any process in which the vacuole is maintained in a specific location within a cell and prevented from moving elsewhere." [PMID:26283797]
synonym: "maintenance of vacuolar localization" EXACT []
synonym: "maintenance of vacuole localization" EXACT []
synonym: "maintenance of vacuole location" EXACT []
is_a: GO:0051640 ! organelle localization
is_a: GO:0051657 ! maintenance of organelle location
is_a: GO:1902580 ! single-organism cellular localization
created_by: mcc
creation_date: 2015-09-10T08:16:02Z

[Term]
id: GO:1990850
name: H-gal-GP complex
namespace: cellular_component
def: "A membrane glycoprotein complex with aspartyl proteinase and metalloproteinase activity which is expressed in the gut. An example of this is found in the nematode Haemonchus contortus." [PMID:11166393]
synonym: "galactose-containing glycoprotein complex" NARROW []
synonym: "Haemonchus galactose-containing glycoprotein complex" EXACT []
is_a: GO:0098796 ! membrane protein complex
is_a: GO:1902494 ! catalytic complex
relationship: part_of GO:0016020 ! membrane
created_by: jl
creation_date: 2015-09-10T16:40:39Z

[Term]
id: GO:1990851
name: Wnt-Frizzled-LRP5/6 complex
namespace: cellular_component
def: "A protein complex containing a secreted Wnt protein associated with its receptor, Frizzled (Fz), and co-receptor low density lipoprotein receptor-related protein 5 (LRP5) or LRP6." [GOC:bf, GOC:PARL, PMID:11448771, PMID:20093360]
comment: Given the number of Wnt proteins, Frizzled proteins and LRP proteins, many different trimeric complexes are likely to form.
synonym: "Frizzled-LRP5/6 complex" RELATED [GOC:bf]
synonym: "Fz/Wnt/LRP6 complex" NARROW [PMID:20093360]
synonym: "Wnt receptor complex" BROAD [GOC:bf]
synonym: "WNT-FZD-LRP5 complex" NARROW [PMID:23209147]
synonym: "Wnt-FZD-LRP5/6 trimeric complex" EXACT [PMID:23209147]
synonym: "WNT-FZD-LRP6 complex" NARROW [PMID:23209147]
synonym: "Wnt-induced Frizzled-LRP5/6 complex" RELATED [GOC:bf]
synonym: "Wnt.Fz.LRP ternary complex" EXACT [PMID:20093360]
is_a: GO:0098797 ! plasma membrane protein complex
relationship: part_of GO:0005886 ! plasma membrane
created_by: bf
creation_date: 2015-09-14T15:59:54Z

[Term]
id: GO:1990852
name: protein transport along microtubule to spindle pole body
namespace: biological_process
def: "The directed movement of a protein along a microtubule to the spindle pole body, mediated by motor proteins." [PMID:25987607]
is_a: GO:0071988 ! protein localization to spindle pole body
is_a: GO:0071989 ! establishment of protein localization to spindle pole body
is_a: GO:0098840 ! protein transport along microtubule
is_a: GO:1902580 ! single-organism cellular localization
created_by: vw
creation_date: 2015-09-15T11:09:54Z

[Term]
id: GO:1990853
name: histone H2A SQE motif phosphorylation
namespace: biological_process
def: "The modification of histone H2A by the addition of an phosphate group to the serine residue in the SQE motif of the histone." [DOI:10.1038/35052000, PMID:15226425]
is_a: GO:0018105 ! peptidyl-serine phosphorylation
is_a: GO:1990164 ! histone H2A phosphorylation
created_by: al
creation_date: 2015-09-15T15:18:02Z

[Term]
id: GO:1990854
name: vacuole-ER tethering
namespace: biological_process
def: "The attachment of a lytic vacuole to the endoplasmic reticulum, which may facilitate exchange of metabolites between the organelles." [PMID:26283797]
synonym: "vacuole-endoplasmic reticulum attachment" EXACT []
synonym: "vacuole-endoplasmic reticulum tethering" EXACT []
synonym: "vacuole-ER attachment" EXACT []
is_a: GO:0016043 ! cellular component organization
is_a: GO:0051685 ! maintenance of ER location
is_a: GO:1990849 ! maintenance of vacuolar location
created_by: mcc
creation_date: 2015-09-15T18:50:04Z

[Term]
id: GO:1990855
name: obsolete myo-inositol import across plasma membrane
namespace: biological_process
def: "OBSOLETE. The directed movement of myo-inositol from outside of a cell into the intracellular region of a cell across the plasma membrane." [PMID:9560432]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
subset: termgenie_unvetted
is_obsolete: true
created_by: al
creation_date: 2015-09-17T16:52:32Z

[Term]
id: GO:1990856
name: methionyl-initiator methionine tRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with methionine-initator methionine tRNA." [GOC:hjd, ISBN:9781555810733]
comment: An example of this is eukaryotic initiation factor 2 complex, which binds the methionyl-initiator methionine tRNA during ternary complex formation. The non-acylated tRNA is not bound.
is_a: GO:0000049 ! tRNA binding
created_by: hjd
creation_date: 2015-09-18T16:56:59Z

[Term]
id: GO:1990857
name: APC-Fzr1/Mfr1 complex
namespace: cellular_component
def: "An anaphase promoting complex bound to an activator in the Fzr1 (human)/Mfr1 (pombe) family." [PMID:11493649]
is_a: GO:0005680 ! anaphase-promoting complex
created_by: al
creation_date: 2015-09-22T13:29:11Z

[Term]
id: GO:1990858
name: cellular response to lectin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lectin stimulus. A lectin is a carbohydrate-binding protein, highly specific for binding sugar moieties." [PMID:25996210, PMID:26306444]
comment: This term refers to endogenous (evolved) responses to lectins (endogenous or exogenous), it does not cover the events that happen due to lectin toxicity.
is_a: GO:1990840 ! response to lectin
created_by: sl
creation_date: 2015-09-24T15:34:42Z

[Term]
id: GO:1990859
name: cellular response to endothelin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an endothelin stimulus. Endothelin is any of three secretory vasoconstrictive peptides (endothelin-1, -2, -3)." [PMID:16365184]
is_a: GO:0071375 ! cellular response to peptide hormone stimulus
is_a: GO:1990839 ! response to endothelin
created_by: sl
creation_date: 2015-09-24T15:39:48Z

[Term]
id: GO:1990860
name: Pho85-Pho80 CDK-cyclin complex
namespace: cellular_component
def: "A cyclin dependent kinase (CDK) complex that contains a kinase subunit and a regulatory cyclin subunit. An example of this complex in budding yeast S. cerevisiae consists of the Pho85 kinase and the Pho80 cyclin." [GOC:rb, PMID:8108735]
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex
created_by: rb
creation_date: 2015-09-24T17:53:50Z

[Term]
id: GO:1990861
name: Ubp3-Bre5 deubiquitination complex
namespace: cellular_component
def: "A protein complex that cleaves ubiquitin from specific substrates. In the budding yeast Saccharomyces cerevisiae, this complex consists of Ubp3p and Bre5p." [GOC:rb, PMID:12778054, PMID:18391941]
synonym: "Ubp3-Bre5 ubiquitin protease complex" EXACT []
is_a: GO:0043234 ! protein complex
created_by: rb
creation_date: 2015-09-24T17:56:53Z

[Term]
id: GO:1990862
name: nuclear membrane complex Bqt3-Bqt4
namespace: cellular_component
def: "A protein complex that resides in the inner nuclear membrane and anchors telomeres to the nuclear envelope. In fission yeast, it is composed of Bqt3 and Bqt4." [PMID:19948484]
is_a: GO:0005639 ! integral component of nuclear inner membrane
is_a: GO:0098796 ! membrane protein complex
created_by: al
creation_date: 2015-09-25T12:14:28Z

[Term]
id: GO:1990863
name: acinar cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of acinar cells, resulting in the expansion of a cell population. An acinar cell is a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini (singular acinus)." [PMID:9788538]
synonym: "acinic cell proliferation" EXACT []
synonym: "acinous cell proliferation" EXACT []
is_a: GO:0050673 ! epithelial cell proliferation
created_by: sl
creation_date: 2015-09-25T14:26:09Z

[Term]
id: GO:1990864
name: response to growth hormone-releasing hormone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone-releasing hormone stimulus. Growth hormone-releasing hormone regulates the release of growth hormone, as well as some pancreatic proteins, and possibly other proteins." [PMID:7720628]
synonym: "response to GHRF" EXACT []
synonym: "response to GRF" EXACT []
synonym: "response to growth hormone-releasing factor" EXACT []
synonym: "response to sermorelin" RELATED []
synonym: "response to somatocrinin" EXACT []
synonym: "response to somatoliberin" EXACT []
synonym: "response to somatorelin" EXACT []
is_a: GO:0009725 ! response to hormone
created_by: sl
creation_date: 2015-09-25T14:45:31Z

[Term]
id: GO:1990865
name: obsolete response to intermittent hypoxia
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an episodic stimulus indicating lowered oxygen tension." [PMID:24055447]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
is_obsolete: true
created_by: sl
creation_date: 2015-09-25T15:07:32Z

[Term]
id: GO:1990866
name: obsolete response to sustained hypoxia
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sustained stimulus indicating lowered oxygen tension." [PMID:24055447]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
is_obsolete: true
created_by: sl
creation_date: 2015-09-25T15:18:11Z

[Term]
id: GO:1990867
name: response to gastrin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gastrin stimulus." [PMID:10348814]
is_a: GO:0043434 ! response to peptide hormone
created_by: sl
creation_date: 2015-09-25T16:22:39Z

[Term]
id: GO:1990868
name: response to chemokine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemokine stimulus." [PMID:11113082]
is_a: GO:0034097 ! response to cytokine
created_by: sl
creation_date: 2015-09-25T16:37:00Z

[Term]
id: GO:1990869
name: cellular response to chemokine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemokine stimulus." [PMID:11113082]
is_a: GO:0071345 ! cellular response to cytokine stimulus
is_a: GO:1990868 ! response to chemokine
created_by: sl
creation_date: 2015-09-25T16:39:55Z

[Term]
id: GO:1990870
name: obsolete protein fibril
namespace: cellular_component
def: "OBSOLETE. A polymer of proteins that form a fine fiber." [PMID:12764608]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
is_obsolete: true
created_by: sl
creation_date: 2015-09-25T17:05:32Z

[Term]
id: GO:1990871
name: Vma12-Vma22 assembly complex
namespace: cellular_component
def: "A protein complex that is involved in the assembly of the V-ATPase complex. In the budding yeast Saccharomyces cerevisiae, this complex consists of Vma12p and Vma22p." [GOC:rb, PMID:9660861]
is_a: GO:0043234 ! protein complex
created_by: rb
creation_date: 2015-09-28T19:03:28Z

[Term]
id: GO:1990872
name: negative regulation of sterol import by negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of sterol import, by down regulation of transcription from an RNA polymerase II promoter." [GOC:rb, PMID:19793923]
comment: An example of this is CLA4, STE20 and SKM1 in yeast in PMID:19793923, inferred by IMP.
synonym: "negative regulation of sterol import by activation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "negative regulation of sterol import by negative regulation of transcription from Pol II promoter" EXACT [GOC:obol]
synonym: "negative regulation of sterol import by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "negative regulation of sterol import by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "negative regulation of sterol import by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "negative regulation of sterol import by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "negative regulation of sterol influx by activation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "negative regulation of sterol influx by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "negative regulation of sterol influx by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "negative regulation of sterol influx by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "negative regulation of sterol influx by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "negative regulation of sterol influx by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "negative regulation of sterol uptake by activation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "negative regulation of sterol uptake by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "negative regulation of sterol uptake by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "negative regulation of sterol uptake by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "negative regulation of sterol uptake by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
synonym: "negative regulation of sterol uptake by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol]
is_a: GO:0035968 ! regulation of sterol import by regulation of transcription from RNA polymerase II promoter
is_a: GO:0072368 ! regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter
is_a: GO:2000910 ! negative regulation of sterol import
intersection_of: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
intersection_of: negatively_regulates GO:0035376 ! sterol import
relationship: negatively_regulates GO:0035376 ! sterol import
created_by: rb
creation_date: 2015-09-28T21:22:23Z

[Term]
id: GO:1990873
name: intrinsic component of plasma membrane of cell tip
namespace: cellular_component
def: "The component of the plasma membrane surrounding the cell tip consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the plasma membrane surrounding the cell tip or some other covalently attached group such as a GPI anchor that is similarly embedded in the plasma membrane surrounding the cell tip." [PMID:20624220]
is_a: GO:0031226 ! intrinsic component of plasma membrane
intersection_of: GO:0031224 ! intrinsic component of membrane
intersection_of: part_of GO:0031520 ! plasma membrane of cell tip
relationship: part_of GO:0031520 ! plasma membrane of cell tip
created_by: al
creation_date: 2015-09-29T10:06:25Z

[Term]
id: GO:1990874
name: vascular smooth muscle cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of vascular smooth muscle cells, resulting in the expansion of a cell population. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels." [PMID:23246467]
synonym: "VSMC proliferation" EXACT []
is_a: GO:0048659 ! smooth muscle cell proliferation
created_by: sl
creation_date: 2015-09-29T16:34:59Z

[Term]
id: GO:1990875
name: nucleoplasmic side of nuclear pore
namespace: cellular_component
def: "The side of the nuclear pore complex (NPC) that faces the nucleoplasm." [PMID:8422679]
synonym: "nucleoplasmic side of NPC" EXACT []
synonym: "nucleoplasmic side of nuclear pore complex" EXACT []
synonym: "nucleoplasmic side of nucleopore" EXACT []
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0005643 ! nuclear pore
created_by: sl
creation_date: 2015-10-01T21:32:22Z

[Term]
id: GO:1990876
name: cytoplasmic side of nuclear pore
namespace: cellular_component
def: "The side of the nuclear pore complex (NPC) that faces the cytoplasm." [PMID:8422679]
synonym: "cytoplasmic side of NPC" EXACT []
synonym: "cytoplasmic side of nuclear pore complex" EXACT []
synonym: "cytoplasmic side of nucleopore" EXACT []
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0005643 ! nuclear pore
created_by: sl
creation_date: 2015-10-01T21:47:54Z

[Term]
id: GO:1990877
name: Lst4-Lst7 complex
namespace: cellular_component
def: "A heterodimeric complex that functions as a GTPase-Activating Protein (GAP) Complex for members of the Rag family of GTPases. In the budding yeast, this complex contains Lst4 and Lst7, while the orthologous mammalian complex contains Follicular (FLCN) and either follicular interaction protein 1 (FNIP1) or FNIP2." [GOC:rn, PMID:24095279, PMID:26387955]
synonym: "FLCN-FNIP1 complex" RELATED []
synonym: "FLCN-FNIP2 complex" RELATED []
synonym: "FNIP-Folliculin RagC/D GAP complex" RELATED []
xref: PMID:24095279
xref: PMID:26387955
is_a: GO:1902773 ! GTPase activator complex
created_by: rb
creation_date: 2015-10-01T22:44:58Z

[Term]
id: GO:1990878
name: cellular response to gastrin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gastrin stimulus." [PMID:10348814]
is_a: GO:0071375 ! cellular response to peptide hormone stimulus
is_a: GO:1990867 ! response to gastrin
created_by: sl
creation_date: 2015-10-07T17:38:14Z

[Term]
id: GO:1990879
name: CST complex
namespace: cellular_component
def: "A complex formed by the association of Cdc13 (CTC1 in mammals) with Stn1 in yeast (OBFC1 in mammals) and Ten1 protein (also TEN1 in mammals) with single-stranded telomeric DNA. The CST complex plays a role in telomere protection." [GOC:BHF, GOC:BHF_telomere, GOC:nc, IntAct:EBI-10043724, IntAct:EBI-8801830, IntAct:EBI-8801947, PMID:19854130, PMID:22965356]
synonym: "Cdc13-Stn1-Ten1 complex" NARROW [GOC:nc]
synonym: "CTC1-OBFC1-TEN1 complex" NARROW [GOC:nc]
is_a: GO:0000783 ! nuclear telomere cap complex
created_by: nc
creation_date: 2015-10-20T13:51:07Z

[Term]
id: GO:1990880
name: cellular detoxification of copper ion
namespace: biological_process
def: "Any process that reduces or removes the toxicity of copper ions in a cell. These include transport of copper cations away from sensitive areas and to compartments or complexes whose purpose is sequestration." [PMID:10369673]
is_a: GO:0010273 ! detoxification of copper ion
is_a: GO:1990748 ! cellular detoxification
relationship: part_of GO:0071280 ! cellular response to copper ion
created_by: al
creation_date: 2015-10-21T14:34:40Z

[Term]
id: GO:1990881
name: obsolete negative regulation of transcription from RNA polymerase II promoter in response to DNA damage
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of DNA damage." [PMID:26150418]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
subset: termgenie_unvetted
synonym: "down regulation of transcription from RNA polymerase II promoter in response to DNA damage" EXACT []
synonym: "down-regulation of transcription from RNA polymerase II promoter in response to DNA damage" EXACT []
synonym: "downregulation of transcription from RNA polymerase II promoter in response to DNA damage" EXACT []
synonym: "inhibition of transcription from RNA polymerase II promoter in response to DNA damage" EXACT []
is_obsolete: true
created_by: mcc
creation_date: 2015-10-28T13:02:18Z

[Term]
id: GO:1990882
name: rRNA acetylation
namespace: biological_process
def: "The modification of rRNA structure by addition of an acetyl group to rRNA. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [PMID:25402480]
is_a: GO:0000154 ! rRNA modification
is_a: GO:1990884 ! RNA acetylation
created_by: al
creation_date: 2015-10-28T13:24:58Z

[Term]
id: GO:1990883
name: rRNA cytidine N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + cytidine = CoA + N4-acetylcytidine. The cytidine is within the polynucleotide chain of an rRNA." [PMID:25402480]
is_a: GO:0008080 ! N-acetyltransferase activity
created_by: al
creation_date: 2015-10-28T13:27:35Z

[Term]
id: GO:1990884
name: RNA acetylation
namespace: biological_process
def: "The posttranscriptional addition of one or more acetyl groups to specific residues in an RNA molecule." [PMID:25402480]
is_a: GO:0009451 ! RNA modification
created_by: mah
creation_date: 2015-10-28T16:28:08Z

[Term]
id: GO:1990885
name: obsolete protein serine/threonine kinase binding
namespace: molecular_function
def: "OBSOLETE. Interacting selectively and non-covalently with a protein serine/threonine kinase." [PMID:16982699]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
is_obsolete: true
created_by: sl
creation_date: 2015-10-28T20:40:57Z

[Term]
id: GO:1990886
name: 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,4-dihydroxy-5-polyprenylbenzoic acid + S-adenosyl-L-methionine = 3-methoxy-4-hydroxy-5-polyprenylbenzoic acid + S-adenosyl-L-homocysteine + H+." [EC:2.1.1.114, PMID:10419476, RHEA:44455]
is_a: GO:0008171 ! O-methyltransferase activity
created_by: sl
creation_date: 2015-10-28T22:12:58Z

[Term]
id: GO:1990887
name: 2-polyprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-polyprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol + S-adenosyl-L-methionine = ubiquinol-n + S-adenosyl-L-homocysteine + H+." [PMID:10419476]
is_a: GO:0008171 ! O-methyltransferase activity
created_by: sl
creation_date: 2015-10-28T22:17:54Z

[Term]
id: GO:1990888
name: 2-polyprenyl-6-hydroxyphenol O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-polyprenyl-6-hydroxyphenol + S-adenosyl-L-methionine = 2-polyprenyl-6-methoxyphenol + S-adenosyl-L-homocysteine + H+." [PMID:10419476]
is_a: GO:0008171 ! O-methyltransferase activity
created_by: sl
creation_date: 2015-10-28T22:31:13Z

[Term]
id: GO:1990889
name: H4K20me3 modified histone binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a histone H4 in which the lysine residue at position 20 has been modified by trimethylation." [PMID:22150589]
is_a: GO:0035064 ! methylated histone binding
created_by: al
creation_date: 2015-10-30T15:43:09Z

[Term]
id: GO:1990890
name: netrin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a netrin receptor." [PMID:8861902, PMID:9126742]
xref: GOC:kmv
is_a: GO:0004871 ! signal transducer activity
is_a: GO:0005102 ! receptor binding
relationship: part_of GO:0038007 ! netrin-activated signaling pathway
created_by: kmv
creation_date: 2015-11-02T22:56:07Z

[Term]
id: GO:1990891
name: mitotic sister chromatid arm separation
namespace: biological_process
def: "The cell cycle process in which sister chromatid arms are physically detached from each other during mitosis." [PMID:21633354]
is_a: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:0051306 ! mitotic sister chromatid separation
created_by: mah
creation_date: 2015-11-03T14:01:16Z

[Term]
id: GO:1990892
name: mitotic chromosome arm chromatin condensation
namespace: biological_process
def: "The cell cycle process in which chromosome arm chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [PMID:21633354]
is_a: GO:0007076 ! mitotic chromosome condensation
created_by: vw
creation_date: 2015-11-03T14:16:59Z

[Term]
id: GO:1990893
name: mitotic chromosome centromere condensation
namespace: biological_process
def: "The cell cycle process in which centromere chromatin structure is compacted prior to and during mitosis." [PMID:21633354]
synonym: "mitotic chromosome condensation at kinetochore" EXACT []
is_a: GO:0007076 ! mitotic chromosome condensation
created_by: vw
creation_date: 2015-11-03T14:26:29Z

[Term]
id: GO:1990894
name: obsolete positive regulation of induction of conjugation with cellular fusion by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in positive regulation of induction of conjugation with cellular fusion." [PMID:22144909]
comment: This term was obsoleted during the TG review process.  It should have been created using a template.
subset: termgenie_unvetted
is_obsolete: true
created_by: al
creation_date: 2015-11-04T20:25:21Z

[Term]
id: GO:1990895
name: regulation of protein localization to cell cortex of cell tip
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to cell cortex of cell tip." [PMID:26150232\,GOC\:vw]
is_a: GO:1903066 ! regulation of protein localization to cell tip
is_a: GO:1904776 ! regulation of protein localization to cell cortex
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990896 ! protein localization to cell cortex of cell tip
relationship: regulates GO:1990896 ! protein localization to cell cortex of cell tip
created_by: vw
creation_date: 2015-11-04T21:53:15Z

[Term]
id: GO:1990896
name: protein localization to cell cortex of cell tip
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, the cell cortex of the cell tip." [PMID:26150232]
is_a: GO:0072697 ! protein localization to cell cortex
is_a: GO:1990151 ! protein localization to cell tip
created_by: vw
creation_date: 2015-11-05T08:41:49Z

[Term]
id: GO:1990897
name: obsolete CTDK-1 complex
namespace: cellular_component
def: "OBSOLETE. A protein complex that phosphorylates serine 2 residues in the CTD domain of productively elongating large subunits of DNA-directed RNA polymerase II, holoenzyme. In S. cerevisiae this complex consists of CTK1/CTK2/CTK3, in S. pombe Lsk1/Lsc1/Lsg1. Human CTK1 homologs include CDK12/13." [PMID:20952539, PMID:24879308]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
subset: termgenie_unvetted
is_obsolete: true
created_by: al
creation_date: 2015-11-06T01:57:32Z

[Term]
id: GO:1990898
name: meiotic DNA double-strand break clipping
namespace: biological_process
def: "The process by which SPO11/Rec12-oligonucleotide complexes are removed from 5' DNA double-strand breaks induced during meiosis. Proteins involved in this process include the MRX/MRN complex and Sae2/Ctp1/RBBP8(CtIP)." [PMID:26130711]
is_a: GO:0044260 ! cellular macromolecule metabolic process
is_a: GO:0044710 ! single-organism metabolic process
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0010705 ! meiotic DNA double-strand break processing involved in reciprocal meiotic recombination
created_by: al
creation_date: 2015-11-10T17:12:27Z

[Term]
id: GO:1990899
name: meiotic DNA double-strand break resectioning
namespace: biological_process
def: "The process following clipping in double-strand break processing of SPO11 induced breaks, where long-tract single-stranded 3'-end DNA is generated from naked (SPO11 has been removed) 5' ends." [PMID:26130711]
is_a: GO:0044260 ! cellular macromolecule metabolic process
is_a: GO:0044710 ! single-organism metabolic process
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0010705 ! meiotic DNA double-strand break processing involved in reciprocal meiotic recombination
created_by: al
creation_date: 2015-11-10T17:23:07Z

[Term]
id: GO:1990900
name: ciliary pocket collar
namespace: cellular_component
def: "A constriction site at the junction of the plasma, flagellar and flagellar pocket membranes where the flagellum emerges from the cell body. Observed in some unicellular eukaryotic species such as Chlamydomonas, Giardia and Trypanosoma." [GOC:giardia, PMID:18462016, PMID:19806154]
comment: Note that a 'flagellar collar' is described in Choanoflagellates, but this is different from the ciliary pocket collar found e.g. in Giardia; in Choanoflagellates, a single apical flagellum is surrounded by a collar of 30-40 microvilli.
synonym: "cilium pocket collar" EXACT []
synonym: "flagellar collar" RELATED []
synonym: "flagellar pocket collar" EXACT []
synonym: "flagellar pore" RELATED []
synonym: "flagellum pocket collar" EXACT []
synonym: "FPC" RELATED []
is_a: GO:0044441 ! ciliary part
relationship: part_of GO:0020016 ! ciliary pocket
created_by: pr
creation_date: 2015-11-17T14:43:55Z

[Term]
id: GO:1990901
name: old cell pole
namespace: cellular_component
def: "The cell pole distal from the most recent cell division. In rod-shaped bacteria, some experiments distinguish between the old and new cell poles after cell division." [GOC:jh2, PMID:10231492, PMID:8226658]
is_a: GO:0060187 ! cell pole
created_by: pr
creation_date: 2015-11-17T16:42:16Z

[Term]
id: GO:1990902
name: new cell pole
namespace: cellular_component
def: "The cell pole proximal to the most recent cell division. In rod-shaped bacteria, some experiments distinguish between the old and new cell poles after cell division." [GOC:jh2, PMID:10231492, PMID:8226658]
is_a: GO:0060187 ! cell pole
created_by: pr
creation_date: 2015-11-17T16:44:53Z

[Term]
id: GO:1990903
name: extracellular ribonucleoprotein complex
namespace: cellular_component
def: "An extracellular macromolecular complex containing both protein and RNA molecules." [GOC:vesicles]
is_a: GO:0044421 ! extracellular region part
is_a: GO:1990904 ! ribonucleoprotein complex
created_by: pr
creation_date: 2015-11-19T10:24:37Z

[Term]
id: GO:1990904
name: ribonucleoprotein complex
namespace: cellular_component
def: "A macromolecular complex containing both protein and RNA molecules." [GOC:vesicles]
synonym: "protein-RNA complex" EXACT []
synonym: "ribonucleoprotein" EXACT []
synonym: "RNA-protein complex" EXACT []
synonym: "RNP" EXACT []
is_a: GO:0032991 ! macromolecular complex
created_by: pr
creation_date: 2015-11-19T12:26:37Z

[Term]
id: GO:1990905
name: dinoflagellate peduncle
namespace: cellular_component
def: "A small, flexible, finger-like appendage located near the flagellar pores in some photosynthetic as well as nonphotosynthetic dinoflagellate species. Its functions are not fully understood, but it has been associated with feeding behavior (phagotrophy)." [GOC:at, http://en.wikipedia.org/wiki/Dinoflagellate, http://species-identification.org/index.php]
comment: The term name refers to a taxonomic group to make the label unique with respect to similarly-named anatomical structures.
is_a: GO:0042995 ! cell projection
created_by: pr
creation_date: 2015-11-22T10:22:46Z

[Term]
id: GO:1990906
name: accessory outer segment
namespace: cellular_component
def: "A cilium-like cell projection emanating from the inner segment and running alongside the outer segment of photoreceptors." [GOC:dph, PMID:25125189]
is_a: GO:0042995 ! cell projection
is_a: GO:0097458 ! neuron part
created_by: dph
creation_date: 2015-11-24T13:56:06Z

[Term]
id: GO:1990907
name: beta-catenin-TCF complex
namespace: cellular_component
def: "A protein complex that contains beta-catenin and a member of the T-cell factor (TCF)/lymphoid enhancer binding factor (LEF) family of transcription factors." [GOC:bf, GOC:PARL, IntAct:EBI-11424678, IntAct:EBI-11425837, PMID:11751639, PMID:16936075, PMID:20123964, PMID:21075118, PMID:9419974]
synonym: "beta-catenin/LEF complex" NARROW [PMID:8757136]
synonym: "beta-catenin/lymphoid enhancer binding factor complex" RELATED [PMID:8757136]
synonym: "beta-catenin/T-cell factor complex" RELATED [GOC:bf]
is_a: GO:0090575 ! RNA polymerase II transcription factor complex
created_by: bf
creation_date: 2015-12-01T16:32:44Z

[Term]
id: GO:1990908
name: obsolete Lys63-specific zinc metallopeptidase deubiquitinase activity
namespace: molecular_function
def: "OBSOLETE. Hydrolysis of Lys63-Linked ubiquitin unit(s) from a ubiquitinated protein by a mechanism where zinc acts as the nucleophile." [PMID:26368668]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
subset: termgenie_unvetted
is_obsolete: true
created_by: al
creation_date: 2015-12-03T14:25:04Z

[Term]
id: GO:1990909
name: Wnt signalosome
namespace: cellular_component
def: "A multiprotein protein complex containing membrane-localized Wnt receptors and cytosolic protein complexes, which is capable of transmitting the Wnt signal. Contains at least a Wnt protein, LRP5 or LRP6, a member of the Frizzled (Fz) family, Axin and and a Dishevelled (DVL) protein." [GOC:bf, GOC:PARL, PMID:22899650, PMID:25336320]
comment: Within the Wnt signalosome, beta-catenin phosphorylation is inhibited through internalization of the signalosome complex, resulting in the sequestration of GSK3-beta into multi-vesicular bodies. No longer phosphorylated and targeted for degradation, beta-catenin is free to enter the nucleus and modulate downstream transcription.
synonym: "LRP5/6 signalosome" EXACT [GOC:bf]
synonym: "LRP6 signalosome" NARROW [PMID:22899650, PMID:25074807]
synonym: "Wnt signalosome complex" EXACT [PMID:24412065]
synonym: "Wnt-LRP5/6 signalosome" EXACT [PMID:23892894]
is_a: GO:0043234 ! protein complex
relationship: has_part GO:1990851 ! Wnt-Frizzled-LRP5/6 complex
created_by: bf
creation_date: 2015-12-07T14:04:23Z

[Term]
id: GO:1990910
name: response to hypobaric hypoxia
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension combined with low atmospheric pressure. Hypoxia is defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95% and hypobaric is defined as atmospheric pressure below 0.74 atm (greater than 2,500 m above sea level)." [PMID:24590457]
is_a: GO:0001666 ! response to hypoxia
created_by: sl
creation_date: 2015-12-07T19:34:14Z

[Term]
id: GO:1990911
name: response to psychosocial stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of exposure to aversive or demanding psychological and social conditions that tax or exceed the behavioral resources of the organism." [PMID:22922217, PMID:26458179]
is_a: GO:0006950 ! response to stress
created_by: sl
creation_date: 2015-12-07T20:38:35Z

[Term]
id: GO:1990912
name: obsolete response to microwave radiation
namespace: biological_process
def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a microwave radiation stimulus." [PMID:21241601]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
subset: termgenie_unvetted
is_obsolete: true
created_by: sl
creation_date: 2015-12-07T21:25:08Z

[Term]
id: GO:1990913
name: sperm head plasma membrane
namespace: cellular_component
def: "The plasma membrane that is part of the head section of a sperm cell." [PMID:24478030]
is_a: GO:0097223 ! sperm part
is_a: GO:0098590 ! plasma membrane region
relationship: part_of GO:0097524 ! sperm plasma membrane
created_by: sl
creation_date: 2015-12-07T23:14:04Z

[Term]
id: GO:1990914
name: integral component of periplasmic side of plasma membrane
namespace: cellular_component
def: "The component of the plasma membrane consisting of the gene products that penetrate only the periplasmic side of the membrane." [GOC:bhm, IntAct:EBI-11297444, PMID:15919996]
comment: An example of this is hyaA in E. coli (P69739) in PMID:23260654 (inferred from direct assay).
is_a: GO:0031237 ! intrinsic component of periplasmic side of plasma membrane
is_a: GO:0071575 ! integral component of external side of plasma membrane
intersection_of: GO:0005887 ! integral component of plasma membrane
intersection_of: part_of GO:0098567 ! periplasmic side of plasma membrane
relationship: part_of GO:0098567 ! periplasmic side of plasma membrane
created_by: bhm
creation_date: 2015-12-09T14:38:57Z

[Term]
id: GO:1990915
name: structural constituent of ascospore wall
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of an ascospore wall." [PMID:24623719]
is_a: GO:0005199 ! structural constituent of cell wall
created_by: al
creation_date: 2015-12-09T19:04:53Z

[Term]
id: GO:1990916
name: Isp3 layer of spore wall
namespace: cellular_component
def: "The outermost layers of the spore wall, as described in Schizosaccharomyces pombe." [PMID:24623719]
is_a: GO:0044426 ! cell wall part
relationship: part_of GO:0005619 ! ascospore wall
created_by: al
creation_date: 2015-12-09T19:07:23Z

[Term]
id: GO:1990917
name: ooplasm
namespace: cellular_component
def: "The cytoplasm of an ovum." [PMID:19022436]
is_a: GO:0005737 ! cytoplasm
created_by: sl
creation_date: 2015-12-10T21:40:16Z

[Term]
id: GO:1990918
name: double-strand break repair involved in meiotic recombination
namespace: biological_process
def: "The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix that contributes to reciprocal meiotic recombination." [GOC:mah, PMID:15238514]
is_a: GO:0006302 ! double-strand break repair
is_a: GO:1903046 ! meiotic cell cycle process
relationship: part_of GO:0007131 ! reciprocal meiotic recombination
created_by: al
creation_date: 2015-12-11T01:01:14Z

[Term]
id: GO:1990919
name: nuclear membrane proteasome anchor
namespace: molecular_function
def: "Interacting selectively and non-covalently with a proteasome complex and a nuclear inner membrane, in order to maintain the nuclear membrane localization of the proteasome." [PMID:16096059]
synonym: "nuclear membrane proteasome adaptor" RELATED []
synonym: "tethering factor for nuclear proteasome" RELATED []
is_a: GO:0043495 ! protein anchor
created_by: vw
creation_date: 2015-12-14T14:01:45Z

[Term]
id: GO:1990920
name: proteasome localization to nuclear periphery
namespace: biological_process
def: "Any process in which the proteasome is transported to, or maintained at the nuclear periphery." [PMID:11084332]
is_a: GO:0031144 ! proteasome localization
is_a: GO:1990139 ! protein localization to nuclear periphery
created_by: vw
creation_date: 2015-12-14T17:14:00Z

[Term]
id: GO:1990921
name: obsolete proteasome localization to nuclear periphery
namespace: biological_process
def: "OBSOLETE. A process in which a proteasome is transported to, or maintained in, a location within the nuclear periphery." [PMID:16096059]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
subset: termgenie_unvetted
synonym: "proteasome localisation to nuclear periphery" EXACT []
is_obsolete: true
created_by: mah
creation_date: 2015-12-15T12:02:31Z

[Term]
id: GO:1990922
name: hepatic stellate cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of hepatic stellate cells, resulting in the expansion of a hepatic stellate cell population. Hepatic stellate cells are found in the perisinusoidal space of the liver, and are capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components. This cell type comprises approximately 8-15% of total cells in the liver." [GOC:sl, PMID:15358192, PMID:18466260]
synonym: "hepatic perisinusoidal cell proliferation" EXACT []
synonym: "Ito cell proliferation" EXACT []
synonym: "perisinusoidal cell proliferation" EXACT []
is_a: GO:0048144 ! fibroblast proliferation
created_by: sl
creation_date: 2016-01-13T23:12:57Z

[Term]
id: GO:1990923
name: PET complex
namespace: cellular_component
def: "A protein complex that is composed of at least EXD1, TDRD12 and some PIWI protein. The complex is required for MILI slicing-triggered biogenesis and loading of MIWI2 piRNAs" [PMID:26669262]
is_a: GO:0043234 ! protein complex
created_by: sp
creation_date: 2016-01-14T02:19:39Z

[Term]
id: GO:1990924
name: obsolete amphisome membrane
namespace: cellular_component
def: "OBSOLETE. The lipid bilayer surrounding the amphisome and separating its contents from the cell cytoplasm." [GOC:bhm, PMID:17984323]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
subset: termgenie_unvetted
synonym: "amphisomal membrane" EXACT []
is_obsolete: true
created_by: bhm
creation_date: 2016-01-27T13:58:16Z

[Term]
id: GO:1990925
name: mitochondrial iron ion transmembrane transport
namespace: biological_process
def: "The directed movement of iron ions from one side of a membrane into, out of or within a mitochondrion." [PMID:12902335]
synonym: "mitochondrial iron cation transmembrane transport" EXACT []
is_a: GO:0034755 ! iron ion transmembrane transport
is_a: GO:0048250 ! mitochondrial iron ion transport
is_a: GO:1990542 ! mitochondrial transmembrane transport
created_by: al
creation_date: 2016-02-10T11:24:22Z

[Term]
id: GO:1990927
name: calcium ion regulated lysosome exocytosis
namespace: biological_process
def: "The process of secretion by a cell that results in the release of intracellular molecules contained within a lysosome by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels." [PMID:10725327, PMID:11511344]
is_a: GO:0017156 ! calcium ion regulated exocytosis
created_by: sp
creation_date: 2016-02-16T14:19:44Z

[Term]
id: GO:1990928
name: response to amino acid starvation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids." [PMID:7765311]
is_a: GO:0042594 ! response to starvation
created_by: sl
creation_date: 2016-02-18T00:18:23Z

[Term]
id: GO:1990929
name: sulfoquinovosidase activity
namespace: molecular_function
def: "Catalyzes the hydrolysis of terminal non-reducing alpha-sulfoquinovoside residues in alpha-sulfoquinovosyl diacylglycerides and alpha-sulfoquinovosyl glycerol, generating alpha-sulfoquinovose." [GOC:imk, PMID:26878550]
is_a: GO:0016798 ! hydrolase activity, acting on glycosyl bonds
created_by: tb
creation_date: 2016-02-19T01:18:37Z

[Term]
id: GO:1990930
name: RNA N1-methyladenosine dioxygenase activity
namespace: molecular_function
def: "Catalysis of the oxidative demethylation of N1-methyladenosine RNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N1-methyladenosine as formaldehyde." [PMID:26863196, PMID:26863410]
is_a: GO:0035515 ! oxidative RNA demethylase activity
created_by: sp
creation_date: 2016-03-10T08:06:47Z

[Term]
id: GO:1990931
name: RNA N6-methyladenosine dioxygenase activity
namespace: molecular_function
def: "Catalysis of the oxidative demethylation of N6-methyladenosine RNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N6-methyladenosine as formaldehyde." [PMID:22002720, PMID:26458103]
is_a: GO:0035515 ! oxidative RNA demethylase activity
created_by: sp
creation_date: 2016-03-10T08:10:10Z

[Term]
id: GO:1990932
name: 5.8S rRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with 5.8S ribosomal RNA, a eukaryotic ribosomal RNA which forms a complex with 28S RNA." [PMID:11716358, PMID:15527424]
is_a: GO:0019843 ! rRNA binding
created_by: sl
creation_date: 2016-03-14T20:25:41Z

[Term]
id: GO:1990933
name: microtubule cytoskeleton attachment to nuclear envelope
namespace: biological_process
def: "A process in which the microtubule cytoskeleton is attached to the nuclear envelope." [PMID:14655046, PMID:20507227]
is_a: GO:0007010 ! cytoskeleton organization
created_by: vw
creation_date: 2016-03-17T08:32:37Z

[Term]
id: GO:1990934
name: nucleolus-like body
namespace: cellular_component
def: "A nuclear compartment containing significant amounts of non-nucleolar, spliceosomal components. It is commonly found in germinal vesicle (GV) stage oocytes, and is similar to both nucleoli and sphere organelles." [PMID:26226217, PMID:9021878]
synonym: "compact nucleolus" EXACT []
synonym: "NLB" EXACT []
synonym: "nucleolus-like body" EXACT []
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0031981 ! nuclear lumen
created_by: sl
creation_date: 2016-03-21T21:28:14Z

[Term]
id: GO:1990935
name: splicing factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any protein involved in the process of removing sections of the primary RNA transcript to form the mature form of the RNA." [PMID:11118435]
is_a: GO:0005515 ! protein binding
created_by: sl
creation_date: 2016-03-21T21:57:20Z

[Term]
id: GO:1990936
name: vascular smooth muscle cell dedifferentiation
namespace: biological_process
def: "The process in which a vascular smooth muscle cell (a non-striated, elongated, spindle-shaped cell found lining the blood vessels) loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:19088079]
is_a: GO:0036166 ! phenotypic switching
is_a: GO:0043697 ! cell dedifferentiation
created_by: tb
creation_date: 2016-03-22T20:25:11Z

[Term]
id: GO:1990937
name: xylan acetylation
namespace: biological_process
def: "The addition of one or more acetyl groups to a xylan molecule." [PMID:26745802]
is_a: GO:0043412 ! macromolecule modification
is_a: GO:0045491 ! xylan metabolic process
created_by: tb
creation_date: 2016-03-30T22:10:22Z

[Term]
id: GO:1990938
name: peptidyl-aspartic acid autophosphorylation
namespace: biological_process
def: "The phosphorylation by a protein of one or more of its own aspartate amino acid residues, or an aspartate residue on an identical protein." [GOC:bf, GOC:PARL, PMID:26134396]
synonym: "aspartyl autophosphorylation" EXACT [PMID:26134396]
synonym: "peptidyl-aspartate autophosphorylation" EXACT [GOC:bf]
is_a: GO:0018217 ! peptidyl-aspartic acid phosphorylation
is_a: GO:0046777 ! protein autophosphorylation
created_by: bf
creation_date: 2016-04-04T10:49:53Z

[Term]
id: GO:1990939
name: ATP-dependent microtubule motor activity
namespace: molecular_function
def: "Catalysis of movement along a microtubule, coupled to the hydrolysis of ATP." [PMID:19686686]
is_a: GO:0003777 ! microtubule motor activity
created_by: vw
creation_date: 2016-04-04T10:59:42Z

[Term]
id: GO:1990940
name: obsolete microtubule sliding involved in mitotic spindle elongation
namespace: biological_process
def: "OBSOLETE. The movement of one microtubule along another microtubule involved in mitotic spindle elongation." [PMID:19686686]
comment: This term was obsoleted at the TermGenie Gatekeeper stage.
subset: termgenie_unvetted
is_obsolete: true
created_by: vw
creation_date: 2016-04-04T11:06:41Z

[Term]
id: GO:1990941
name: mitotic spindle kinetochore microtubule
namespace: cellular_component
def: "Any of the mitotic spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic chromosome segregation." [PMID:18256284]
is_a: GO:0005828 ! kinetochore microtubule
is_a: GO:1990498 ! mitotic spindle microtubule
created_by: vw
creation_date: 2016-04-06T13:31:38Z

[Term]
id: GO:1990942
name: mitotic metaphase chromosome recapture
namespace: biological_process
def: "A mechanism to recapture 'lost' chromosomes (chromosomes which have become detached from the spindle) during metaphase of mitotic chromosome segregation. Chromosomes with unattached kinetochores are migrated along (non polar) spindle microtubules to the mitotic spindle pole body by a combination of microtubule depolymerisation and 'kinetochore sliding' (migration of the chromosome along the microtubule). The chromosome subsequently migrates along the polar spindle microtubule to the metaphase plate." [PMID:18256284]
synonym: "kinetochore retrieval" EXACT []
synonym: "metaphase chromosome retrieval to the spindle pole body" EXACT []
synonym: "sister kinetochore recapture" EXACT []
is_a: GO:0051303 ! establishment of chromosome localization
relationship: part_of GO:0007080 ! mitotic metaphase plate congression
created_by: vw
creation_date: 2016-04-06T14:41:56Z

[Term]
id: GO:1990943
name: mating type region replication fork barrier binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the replication fork barrier found in the mating type region of fission yeast." [PMID:18723894]
synonym: "RTS1 barrier binding" EXACT []
synonym: "RTS1 element binding" EXACT []
is_a: GO:0031634 ! replication fork barrier binding
created_by: mah
creation_date: 2016-04-06T16:08:43Z

[Term]
id: GO:1990944
name: maintenance of spindle pole body localization
namespace: biological_process
def: "Any process in which a spindle pole body is transported to, or maintained in, a specific location. A spindle pole body is a type of microtubule organizing center found in fungal cells." [PMID:12390246]
synonym: "maintenance of SPB localization" EXACT []
synonym: "maintenance of spindle pole body localisation" EXACT []
synonym: "maintenance of spindle pole body location" EXACT []
is_a: GO:0051657 ! maintenance of organelle location
relationship: part_of GO:0070631 ! spindle pole body localization
created_by: mah
creation_date: 2016-04-11T12:16:59Z

[Term]
id: GO:1990945
name: protein location to meiotic spindle pole body
namespace: biological_process
def: "A process in which a protein is transported to, or maintained at the meiotic spindle pole body." [PMID:20833892]
is_a: GO:0034613 ! cellular protein localization
created_by: vw
creation_date: 2016-04-11T17:31:37Z

[Term]
id: GO:1990946
name: meiosis I/meiosis II transition
namespace: biological_process
def: "The cell cycle process in which a cell progresses from meiosis I to meiosis II." [PMID:21389117]
is_a: GO:0044771 ! meiotic cell cycle phase transition
created_by: vw
creation_date: 2016-04-21T13:01:07Z

[Term]
id: GO:1990947
name: exit from meiosis
namespace: biological_process
def: "Any process involved in the progression from anaphase/telophase of meiosis II to G1 of mitosis." [PMID:212917197]
is_a: GO:0044771 ! meiotic cell cycle phase transition
created_by: vw
creation_date: 2016-04-21T14:14:15Z

[Term]
id: GO:1990948
name: ubiquitin ligase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a ubiquitin ligase." [PMID:21389117]
is_a: GO:0055104 ! ligase inhibitor activity
created_by: vw
creation_date: 2016-04-21T16:36:54Z

[Term]
id: GO:1990949
name: metaphase/anaphase transition of meiosis I
namespace: biological_process
def: "The cell cycle process in which a cell progresses from metaphase to anaphase as part of meiosis I." [ISBN:0185316194]
synonym: "first meiotic metaphase/anaphase transition" RELATED []
synonym: "meiosis I metaphase/anaphase transition" EXACT []
is_a: GO:0044785 ! metaphase/anaphase transition of meiotic cell cycle
relationship: part_of GO:0007127 ! meiosis I
created_by: mah
creation_date: 2016-04-25T15:27:32Z

[Term]
id: GO:1990950
name: metaphase/anaphase transition of meiosis II
namespace: biological_process
def: "The cell cycle process in which a cell progresses from metaphase to anaphase as part of meiosis II." [ISBN:0185316194]
synonym: "meiosis II metaphase/anaphase transition" EXACT []
synonym: "second meiotic metaphase/anaphase transition" RELATED []
is_a: GO:0044785 ! metaphase/anaphase transition of meiotic cell cycle
relationship: part_of GO:0007135 ! meiosis II
created_by: mah
creation_date: 2016-04-25T15:28:51Z

[Term]
id: GO:2000001
name: regulation of DNA damage checkpoint
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a DNA damage checkpoint." [GOC:obol]
synonym: "regulation of DNA damage response, signal transduction resulting in cell cycle arrest" RELATED [GOC:obol]
is_a: GO:1901976 ! regulation of cell cycle checkpoint
is_a: GO:2001020 ! regulation of response to DNA damage stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000077 ! DNA damage checkpoint
relationship: regulates GO:0000077 ! DNA damage checkpoint
created_by: janelomax
creation_date: 2010-07-15T03:25:00Z

[Term]
id: GO:2000002
name: negative regulation of DNA damage checkpoint
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a DNA damage checkpoint." [GOC:BHF, GOC:obol]
synonym: "negative regulation of DNA damage response, signal transduction resulting in cell cycle arrest" RELATED [GOC:obol]
is_a: GO:1901977 ! negative regulation of cell cycle checkpoint
is_a: GO:2000001 ! regulation of DNA damage checkpoint
is_a: GO:2001021 ! negative regulation of response to DNA damage stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000077 ! DNA damage checkpoint
relationship: negatively_regulates GO:0000077 ! DNA damage checkpoint
created_by: janelomax
creation_date: 2010-07-15T03:25:06Z

[Term]
id: GO:2000003
name: positive regulation of DNA damage checkpoint
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a DNA damage checkpoint." [GOC:obol]
synonym: "positive regulation of DNA damage response, signal transduction resulting in cell cycle arrest" RELATED [GOC:obol]
is_a: GO:1901978 ! positive regulation of cell cycle checkpoint
is_a: GO:2000001 ! regulation of DNA damage checkpoint
is_a: GO:2001022 ! positive regulation of response to DNA damage stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000077 ! DNA damage checkpoint
relationship: positively_regulates GO:0000077 ! DNA damage checkpoint
created_by: janelomax
creation_date: 2010-07-15T03:25:10Z

[Term]
id: GO:2000004
name: regulation of metanephric S-shaped body morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of metanephric S-shaped body morphogenesis." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf]
is_a: GO:0072215 ! regulation of metanephros development
is_a: GO:2000027 ! regulation of organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072284 ! metanephric S-shaped body morphogenesis
relationship: regulates GO:0072284 ! metanephric S-shaped body morphogenesis
created_by: jane
creation_date: 2010-07-30T02:14:33Z

[Term]
id: GO:2000005
name: negative regulation of metanephric S-shaped body morphogenesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of metanephric S-shaped body morphogenesis." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf]
is_a: GO:0072217 ! negative regulation of metanephros development
is_a: GO:2000004 ! regulation of metanephric S-shaped body morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072284 ! metanephric S-shaped body morphogenesis
relationship: negatively_regulates GO:0072284 ! metanephric S-shaped body morphogenesis
created_by: jane
creation_date: 2010-07-30T02:14:37Z

[Term]
id: GO:2000006
name: regulation of metanephric comma-shaped body morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of metanephric comma-shaped body morphogenesis." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf]
is_a: GO:0072215 ! regulation of metanephros development
is_a: GO:2000027 ! regulation of organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072278 ! metanephric comma-shaped body morphogenesis
relationship: regulates GO:0072278 ! metanephric comma-shaped body morphogenesis
created_by: jane
creation_date: 2010-07-30T02:17:12Z

[Term]
id: GO:2000007
name: negative regulation of metanephric comma-shaped body morphogenesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of metanephric comma-shaped body morphogenesis." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf]
is_a: GO:0072217 ! negative regulation of metanephros development
is_a: GO:2000006 ! regulation of metanephric comma-shaped body morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072278 ! metanephric comma-shaped body morphogenesis
relationship: negatively_regulates GO:0072278 ! metanephric comma-shaped body morphogenesis
created_by: jane
creation_date: 2010-07-30T02:17:17Z

[Term]
id: GO:2000008
name: regulation of protein localization to cell surface
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to the cell surface." [GOC:obol]
synonym: "regulation of protein localisation at cell surface" EXACT [GOC:mah]
synonym: "regulation of protein localization at cell surface" EXACT [GOC:curators]
is_a: GO:1903827 ! regulation of cellular protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034394 ! protein localization to cell surface
relationship: regulates GO:0034394 ! protein localization to cell surface
created_by: jane
creation_date: 2010-08-04T01:43:48Z

[Term]
id: GO:2000009
name: negative regulation of protein localization to cell surface
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to the cell surface." [GOC:obol]
synonym: "negative regulation of protein localisation at cell surface" EXACT [GOC:mah]
synonym: "negative regulation of protein localization at cell surface" EXACT [GOC:curators]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:1903828 ! negative regulation of cellular protein localization
is_a: GO:2000008 ! regulation of protein localization to cell surface
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034394 ! protein localization to cell surface
relationship: negatively_regulates GO:0034394 ! protein localization to cell surface
created_by: jane
creation_date: 2010-08-04T01:43:52Z

[Term]
id: GO:2000010
name: positive regulation of protein localization to cell surface
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to the cell surface." [GOC:obol]
synonym: "positive regulation of protein localisation at cell surface" EXACT [GOC:mah]
synonym: "positive regulation of protein localization at cell surface" EXACT [GOC:curators]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:1903829 ! positive regulation of cellular protein localization
is_a: GO:2000008 ! regulation of protein localization to cell surface
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034394 ! protein localization to cell surface
relationship: positively_regulates GO:0034394 ! protein localization to cell surface
created_by: jane
creation_date: 2010-08-04T01:43:56Z

[Term]
id: GO:2000011
name: regulation of adaxial/abaxial pattern formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of adaxial/abaxial pattern formation." [GOC:obol]
synonym: "regulation of adaxial/abaxial pattern specification" RELATED [GOC:obol]
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009955 ! adaxial/abaxial pattern specification
relationship: regulates GO:0009955 ! adaxial/abaxial pattern specification
created_by: tanyaberardini
creation_date: 2010-08-05T11:20:22Z

[Term]
id: GO:2000012
name: regulation of auxin polar transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of auxin polar transport." [GOC:obol]
is_a: GO:0010817 ! regulation of hormone levels
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009926 ! auxin polar transport
relationship: regulates GO:0009926 ! auxin polar transport
created_by: tanyaberardini
creation_date: 2010-08-05T11:21:09Z

[Term]
id: GO:2000013
name: regulation of arginine biosynthetic process via ornithine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of arginine biosynthetic process via ornithine." [GOC:obol]
synonym: "regulation of arginine anabolism via ornithine" EXACT [GOC:obol]
synonym: "regulation of arginine formation via ornithine" EXACT [GOC:obol]
synonym: "regulation of arginine synthesis via ornithine" EXACT [GOC:obol]
is_a: GO:0090368 ! regulation of ornithine metabolic process
is_a: GO:1900079 ! regulation of arginine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042450 ! arginine biosynthetic process via ornithine
relationship: regulates GO:0042450 ! arginine biosynthetic process via ornithine
created_by: tanyaberardini
creation_date: 2010-08-05T11:21:51Z

[Term]
id: GO:2000014
name: regulation of endosperm development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endosperm development." [GOC:obol]
is_a: GO:0080050 ! regulation of seed development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009960 ! endosperm development
relationship: regulates GO:0009960 ! endosperm development
created_by: tanyaberardini
creation_date: 2010-08-05T11:22:21Z

[Term]
id: GO:2000015
name: regulation of determination of dorsal identity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of determination of dorsal identity." [GOC:obol]
synonym: "regulation of determination of adaxial identity" RELATED [GOC:obol]
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048263 ! determination of dorsal identity
relationship: regulates GO:0048263 ! determination of dorsal identity
created_by: janelomax
creation_date: 2010-07-15T03:27:49Z

[Term]
id: GO:2000016
name: negative regulation of determination of dorsal identity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of determination of dorsal identity." [GOC:BHF, GOC:obol]
synonym: "negative regulation of determination of adaxial identity" RELATED [GOC:obol]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000015 ! regulation of determination of dorsal identity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048263 ! determination of dorsal identity
relationship: negatively_regulates GO:0048263 ! determination of dorsal identity
created_by: janelomax
creation_date: 2010-07-15T03:27:55Z

[Term]
id: GO:2000017
name: positive regulation of determination of dorsal identity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of determination of dorsal identity." [GOC:obol]
synonym: "positive regulation of determination of adaxial identity" RELATED [GOC:obol]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000015 ! regulation of determination of dorsal identity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048263 ! determination of dorsal identity
relationship: positively_regulates GO:0048263 ! determination of dorsal identity
created_by: janelomax
creation_date: 2010-07-15T03:27:59Z

[Term]
id: GO:2000018
name: regulation of male gonad development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of male gonad development." [GOC:obol, GOC:yaf]
synonym: "regulation of testicular development" EXACT [GOC:obol]
synonym: "regulation of testis development" EXACT [GOC:obol]
is_a: GO:2000026 ! regulation of multicellular organismal development
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008584 ! male gonad development
relationship: regulates GO:0008584 ! male gonad development
created_by: janelomax
creation_date: 2010-07-15T03:29:05Z

[Term]
id: GO:2000019
name: negative regulation of male gonad development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of male gonad development." [GOC:obol, GOC:yaf]
synonym: "negative regulation of testicular development" EXACT [GOC:obol]
synonym: "negative regulation of testis development" EXACT [GOC:obol]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000018 ! regulation of male gonad development
is_a: GO:2000242 ! negative regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008584 ! male gonad development
relationship: negatively_regulates GO:0008584 ! male gonad development
created_by: janelomax
creation_date: 2010-07-15T03:29:10Z

[Term]
id: GO:2000020
name: positive regulation of male gonad development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of male gonad development." [GOC:obol]
synonym: "positive regulation of testicular development" EXACT [GOC:obol]
synonym: "positive regulation of testis development" EXACT [GOC:obol]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000018 ! regulation of male gonad development
is_a: GO:2000243 ! positive regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008584 ! male gonad development
relationship: positively_regulates GO:0008584 ! male gonad development
created_by: janelomax
creation_date: 2010-07-15T03:29:13Z

[Term]
id: GO:2000021
name: regulation of ion homeostasis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ion homeostasis." [GOC:obol]
synonym: "regulation of electrolyte homeostasis" RELATED [GOC:obol]
synonym: "regulation of negative regulation of crystal biosynthesis" RELATED [GOC:obol]
synonym: "regulation of negative regulation of crystal formation" RELATED [GOC:obol]
is_a: GO:0032844 ! regulation of homeostatic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050801 ! ion homeostasis
relationship: regulates GO:0050801 ! ion homeostasis
created_by: tanyaberardini
creation_date: 2010-08-05T11:23:27Z

[Term]
id: GO:2000022
name: regulation of jasmonic acid mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of jasmonic acid mediated signaling pathway." [GOC:obol]
synonym: "regulation of jasmonic acid mediated signalling pathway" EXACT [GOC:obol]
is_a: GO:0009966 ! regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009867 ! jasmonic acid mediated signaling pathway
relationship: regulates GO:0009867 ! jasmonic acid mediated signaling pathway
created_by: tanyaberardini
creation_date: 2010-08-05T11:24:11Z

[Term]
id: GO:2000023
name: regulation of lateral root development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lateral root development." [GOC:obol]
is_a: GO:2000069 ! regulation of post-embryonic root development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048527 ! lateral root development
relationship: regulates GO:0048527 ! lateral root development
created_by: tanyaberardini
creation_date: 2010-08-05T11:24:50Z

[Term]
id: GO:2000024
name: regulation of leaf development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of leaf development." [GOC:obol]
is_a: GO:0048831 ! regulation of shoot system development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048366 ! leaf development
relationship: regulates GO:0048366 ! leaf development
created_by: tanyaberardini
creation_date: 2010-08-05T11:25:14Z

[Term]
id: GO:2000025
name: regulation of leaf formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of leaf formation." [GOC:obol]
is_a: GO:0003156 ! regulation of organ formation
is_a: GO:1901371 ! regulation of leaf morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010338 ! leaf formation
relationship: regulates GO:0010338 ! leaf formation
created_by: tanyaberardini
creation_date: 2010-08-05T11:25:37Z

[Term]
id: GO:2000026
name: regulation of multicellular organismal development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of multicellular organismal development." [GOC:obol]
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007275 ! multicellular organism development
relationship: regulates GO:0007275 ! multicellular organism development
created_by: tanyaberardini
creation_date: 2010-08-05T11:25:59Z

[Term]
id: GO:2000027
name: regulation of organ morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of organ morphogenesis." [GOC:obol]
synonym: "regulation of histogenesis and organogenesis" RELATED [GOC:obol]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009887 ! organ morphogenesis
relationship: regulates GO:0009887 ! organ morphogenesis
created_by: tanyaberardini
creation_date: 2010-08-05T11:26:27Z

[Term]
id: GO:2000028
name: regulation of photoperiodism, flowering
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of photoperiodism, flowering." [GOC:obol]
synonym: "regulation of photoperiodic control of flowering time" EXACT [GOC:obol]
synonym: "regulation of photoperiodic control of inflorescence development" EXACT [GOC:obol]
synonym: "regulation of response to day length, flowering" EXACT [GOC:obol]
synonym: "regulation of response to night length, flowering" EXACT [GOC:obol]
synonym: "regulation of response to photoperiod, flowering" EXACT [GOC:obol]
is_a: GO:0048580 ! regulation of post-embryonic development
is_a: GO:0048583 ! regulation of response to stimulus
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048573 ! photoperiodism, flowering
relationship: regulates GO:0048573 ! photoperiodism, flowering
created_by: tanyaberardini
creation_date: 2010-08-05T11:27:18Z

[Term]
id: GO:2000029
name: regulation of proanthocyanidin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of proanthocyanidin biosynthetic process." [GOC:obol]
synonym: "regulation of proanthocyanidin anabolism" EXACT [GOC:obol]
synonym: "regulation of proanthocyanidin biosynthesis" EXACT [GOC:obol]
synonym: "regulation of proanthocyanidin formation" EXACT [GOC:obol]
synonym: "regulation of proanthocyanidin synthesis" EXACT [GOC:obol]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
is_a: GO:2000762 ! regulation of phenylpropanoid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010023 ! proanthocyanidin biosynthetic process
relationship: regulates GO:0010023 ! proanthocyanidin biosynthetic process
created_by: tanyaberardini
creation_date: 2010-08-05T11:28:08Z

[Term]
id: GO:2000030
name: regulation of response to red or far red light
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to red or far red light." [GOC:obol]
is_a: GO:0048583 ! regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009639 ! response to red or far red light
relationship: regulates GO:0009639 ! response to red or far red light
created_by: tanyaberardini
creation_date: 2010-08-05T11:30:10Z

[Term]
id: GO:2000031
name: regulation of salicylic acid mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of salicylic acid mediated signaling pathway." [GOC:obol]
synonym: "regulation of salicylic acid mediated signalling pathway" EXACT [GOC:obol]
is_a: GO:0009966 ! regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009863 ! salicylic acid mediated signaling pathway
relationship: regulates GO:0009863 ! salicylic acid mediated signaling pathway
created_by: tanyaberardini
creation_date: 2010-08-05T11:32:24Z

[Term]
id: GO:2000032
name: regulation of secondary shoot formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of secondary shoot formation." [GOC:obol]
synonym: "regulation of auxiliary shoot formation" RELATED [GOC:obol]
synonym: "regulation of axillary shoot formation" RELATED [GOC:obol]
synonym: "regulation of axillary shoot system formation" EXACT []
synonym: "regulation of shoot branching" RELATED []
is_a: GO:0060688 ! regulation of morphogenesis of a branching structure
is_a: GO:1900618 ! regulation of shoot system morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010223 ! secondary shoot formation
relationship: regulates GO:0010223 ! secondary shoot formation
created_by: tanyaberardini
creation_date: 2010-08-05T11:32:50Z

[Term]
id: GO:2000033
name: regulation of seed dormancy process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of seed dormancy process." [GOC:obol, GOC:pr, ISBN:9781405139830]
synonym: "regulation of seed dormancy" RELATED []
is_a: GO:2000034 ! regulation of seed maturation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010162 ! seed dormancy process
relationship: regulates GO:0010162 ! seed dormancy process
created_by: tanyaberardini
creation_date: 2010-08-05T11:33:13Z

[Term]
id: GO:2000034
name: regulation of seed maturation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of seed maturation." [GOC:obol]
is_a: GO:0080050 ! regulation of seed development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010431 ! seed maturation
relationship: regulates GO:0010431 ! seed maturation
created_by: tanyaberardini
creation_date: 2010-08-05T11:33:33Z

[Term]
id: GO:2000035
name: regulation of stem cell division
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of stem cell division." [GOC:obol]
synonym: "regulation of stem cell renewal" EXACT [GOC:obol]
is_a: GO:0051302 ! regulation of cell division
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0017145 ! stem cell division
relationship: regulates GO:0017145 ! stem cell division
created_by: tanyaberardini
creation_date: 2010-08-05T11:34:53Z

[Term]
id: GO:2000036
name: regulation of stem cell population maintenance
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of stem cell population maintenance." [GOC:obol]
synonym: "regulation of maintenance of pluripotency" RELATED [GOC:obol]
is_a: GO:0051239 ! regulation of multicellular organismal process
is_a: GO:0060284 ! regulation of cell development
is_a: GO:2000736 ! regulation of stem cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019827 ! stem cell population maintenance
relationship: regulates GO:0019827 ! stem cell population maintenance
created_by: tanyaberardini
creation_date: 2010-08-05T11:35:25Z

[Term]
id: GO:2000037
name: regulation of stomatal complex patterning
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of stomatal complex patterning." [GOC:obol]
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010375 ! stomatal complex patterning
relationship: regulates GO:0010375 ! stomatal complex patterning
created_by: tanyaberardini
creation_date: 2010-08-05T11:35:47Z

[Term]
id: GO:2000038
name: regulation of stomatal complex development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of stomatal complex development." [GOC:obol]
is_a: GO:0048580 ! regulation of post-embryonic development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010374 ! stomatal complex development
relationship: regulates GO:0010374 ! stomatal complex development
created_by: tanyaberardini
creation_date: 2010-08-05T11:36:10Z

[Term]
id: GO:2000039
name: regulation of trichome morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of trichome morphogenesis." [GOC:obol]
synonym: "regulation of trichome cell morphogenesis during differentiation" EXACT [GOC:obol]
is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation
is_a: GO:2000024 ! regulation of leaf development
is_a: GO:2000027 ! regulation of organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010090 ! trichome morphogenesis
relationship: regulates GO:0010090 ! trichome morphogenesis
created_by: tanyaberardini
creation_date: 2010-08-05T11:36:31Z

[Term]
id: GO:2000040
name: regulation of planar cell polarity pathway involved in axis elongation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in axis elongation." [GOC:dph]
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:2000095 ! regulation of Wnt signaling pathway, planar cell polarity pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003402 ! planar cell polarity pathway involved in axis elongation
relationship: regulates GO:0003402 ! planar cell polarity pathway involved in axis elongation
created_by: dph
creation_date: 2010-08-18T02:47:49Z

[Term]
id: GO:2000041
name: negative regulation of planar cell polarity pathway involved in axis elongation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in axis elongation." [GOC:dph]
is_a: GO:0048640 ! negative regulation of developmental growth
is_a: GO:2000040 ! regulation of planar cell polarity pathway involved in axis elongation
is_a: GO:2000051 ! negative regulation of non-canonical Wnt signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003402 ! planar cell polarity pathway involved in axis elongation
relationship: negatively_regulates GO:0003402 ! planar cell polarity pathway involved in axis elongation
created_by: dph
creation_date: 2010-08-18T02:47:54Z

[Term]
id: GO:2000042
name: negative regulation of double-strand break repair via homologous recombination
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of double-strand break repair via homologous recombination." [GOC:vw]
synonym: "negative regulation of HDR" EXACT [GOC:obol]
synonym: "negative regulation of homologous recombinational repair" EXACT [GOC:obol]
synonym: "negative regulation of homology-directed repair" EXACT [GOC:obol]
synonym: "negative regulation of HRR" EXACT [GOC:obol]
synonym: "negative regulation of Rad51-dependent recombinational repair" EXACT [GOC:obol]
synonym: "negative regulation of Rhp51-dependent recombinational repair" EXACT [GOC:obol]
is_a: GO:0010569 ! regulation of double-strand break repair via homologous recombination
is_a: GO:0045910 ! negative regulation of DNA recombination
is_a: GO:2000780 ! negative regulation of double-strand break repair
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000724 ! double-strand break repair via homologous recombination
relationship: negatively_regulates GO:0000724 ! double-strand break repair via homologous recombination
created_by: tanyaberardini
creation_date: 2010-08-19T06:37:08Z

[Term]
id: GO:2000043
name: regulation of cardiac cell fate specification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac cell fate specification." [GOC:BHF]
is_a: GO:0042659 ! regulation of cell fate specification
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060912 ! cardiac cell fate specification
relationship: regulates GO:0060912 ! cardiac cell fate specification
created_by: tanyaberardini
creation_date: 2010-08-19T09:01:04Z

[Term]
id: GO:2000044
name: negative regulation of cardiac cell fate specification
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac cell fate specification." [GOC:BHF]
is_a: GO:0009996 ! negative regulation of cell fate specification
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000043 ! regulation of cardiac cell fate specification
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060912 ! cardiac cell fate specification
relationship: negatively_regulates GO:0060912 ! cardiac cell fate specification
created_by: tanyaberardini
creation_date: 2010-08-19T09:01:10Z

[Term]
id: GO:2000045
name: regulation of G1/S transition of mitotic cell cycle
namespace: biological_process
def: "Any cell cycle regulatory process that controls the commitment of a cell from G1 to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle]
comment: Note that this process is usually achieved by the regulation of the G1 cyclin-dependent protein kinase, consider annotating to the child term 'regulation of cyclin-dependent protein kinase activity involved in G1/S ; GO:0031657'.
is_a: GO:1901990 ! regulation of mitotic cell cycle phase transition
is_a: GO:1902806 ! regulation of cell cycle G1/S phase transition
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000082 ! G1/S transition of mitotic cell cycle
relationship: regulates GO:0000082 ! G1/S transition of mitotic cell cycle
created_by: tanyaberardini
creation_date: 2010-08-19T09:10:56Z

[Term]
id: GO:2000046
name: obsolete regulation of G2 phase of mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of G2 phase of mitotic cell cycle." [GOC:mtg_cell_cycle, GOC:vw]
comment: This term was made obsolete because we felt that phases themselves are not being regulated, it's rather the transitions between phases. If you are trying to make an annotation to x phase, it is likely that the correct process is 'regulation of x/y phase transiition.
synonym: "regulation of G2 phase of mitotic cell cycle" EXACT []
is_obsolete: true
consider: GO:0010389
created_by: tanyaberardini
creation_date: 2010-08-19T09:19:18Z

[Term]
id: GO:2000047
name: regulation of cell-cell adhesion mediated by cadherin
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell-cell adhesion mediated by cadherin." [GOC:obol]
is_a: GO:0022407 ! regulation of cell-cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044331 ! cell-cell adhesion mediated by cadherin
relationship: regulates GO:0044331 ! cell-cell adhesion mediated by cadherin
created_by: jane
creation_date: 2010-08-20T12:56:44Z

[Term]
id: GO:2000048
name: negative regulation of cell-cell adhesion mediated by cadherin
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell-cell adhesion mediated by cadherin." [GOC:obol]
is_a: GO:0022408 ! negative regulation of cell-cell adhesion
is_a: GO:2000047 ! regulation of cell-cell adhesion mediated by cadherin
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044331 ! cell-cell adhesion mediated by cadherin
relationship: negatively_regulates GO:0044331 ! cell-cell adhesion mediated by cadherin
created_by: jane
creation_date: 2010-08-20T12:56:51Z

[Term]
id: GO:2000049
name: positive regulation of cell-cell adhesion mediated by cadherin
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell-cell adhesion mediated by cadherin." [GOC:obol]
is_a: GO:0022409 ! positive regulation of cell-cell adhesion
is_a: GO:2000047 ! regulation of cell-cell adhesion mediated by cadherin
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044331 ! cell-cell adhesion mediated by cadherin
relationship: positively_regulates GO:0044331 ! cell-cell adhesion mediated by cadherin
created_by: jane
creation_date: 2010-08-20T12:56:57Z

[Term]
id: GO:2000050
name: regulation of non-canonical Wnt signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of non-canonical Wnt signaling pathway." [GOC:obol, GOC:yaf]
synonym: "regulation of beta-catenin-independent Wnt receptor signaling pathway" EXACT [GOC:obol]
synonym: "regulation of non-canonical Wnt receptor signaling pathway" EXACT []
synonym: "regulation of non-canonical Wnt receptor signalling pathway" EXACT [GOC:mah]
synonym: "regulation of non-canonical Wnt-activated signaling pathway" EXACT [GOC:signaling]
is_a: GO:0030111 ! regulation of Wnt signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035567 ! non-canonical Wnt signaling pathway
relationship: regulates GO:0035567 ! non-canonical Wnt signaling pathway
created_by: jane
creation_date: 2010-08-20T01:04:12Z

[Term]
id: GO:2000051
name: negative regulation of non-canonical Wnt signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of non-canonical Wnt signaling pathway." [GOC:obol, GOC:yaf]
synonym: "negative regulation of beta-catenin-independent Wnt receptor signaling pathway" EXACT [GOC:obol]
synonym: "negative regulation of non-canonical Wnt receptor signaling pathway" EXACT []
synonym: "negative regulation of non-canonical Wnt receptor signalling pathway" EXACT [GOC:mah]
synonym: "negative regulation of non-canonical Wnt-activated signaling pathway" EXACT [GOC:signaling]
is_a: GO:0030178 ! negative regulation of Wnt signaling pathway
is_a: GO:2000050 ! regulation of non-canonical Wnt signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035567 ! non-canonical Wnt signaling pathway
relationship: negatively_regulates GO:0035567 ! non-canonical Wnt signaling pathway
created_by: jane
creation_date: 2010-08-20T01:04:20Z

[Term]
id: GO:2000052
name: positive regulation of non-canonical Wnt signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of non-canonical Wnt-activated signaling pathway." [GOC:obol, GOC:yaf]
synonym: "positive regulation of beta-catenin-independent Wnt receptor signaling pathway" EXACT [GOC:obol]
synonym: "positive regulation of non-canonical Wnt receptor signaling pathway" EXACT []
synonym: "positive regulation of non-canonical Wnt receptor signalling pathway" EXACT [GOC:mah]
synonym: "positive regulation of non-canonical Wnt-activated signaling pathway" EXACT [GOC:signaling]
is_a: GO:0030177 ! positive regulation of Wnt signaling pathway
is_a: GO:2000050 ! regulation of non-canonical Wnt signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035567 ! non-canonical Wnt signaling pathway
relationship: positively_regulates GO:0035567 ! non-canonical Wnt signaling pathway
created_by: jane
creation_date: 2010-08-20T01:04:25Z

[Term]
id: GO:2000053
name: regulation of Wnt signaling pathway involved in dorsal/ventral axis specification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Wnt signaling pathway involved in dorsal/ventral axis specification." [GOC:obol, GOC:yaf]
synonym: "regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification" EXACT []
synonym: "regulation of Wnt receptor signalling pathway involved in dorsal/ventral axis specification" EXACT [GOC:mah]
synonym: "regulation of Wnt-activated signaling pathway involved in dorsal/ventral axis specification" EXACT [GOC:signaling]
is_a: GO:0030111 ! regulation of Wnt signaling pathway
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044332 ! Wnt signaling pathway involved in dorsal/ventral axis specification
relationship: regulates GO:0044332 ! Wnt signaling pathway involved in dorsal/ventral axis specification
created_by: jane
creation_date: 2010-08-20T01:13:28Z

[Term]
id: GO:2000054
name: negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Wnt signaling pathway involved in dorsal/ventral axis specification." [GOC:obol, GOC:yaf]
synonym: "negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification" EXACT []
synonym: "negative regulation of Wnt receptor signalling pathway involved in dorsal/ventral axis specification" EXACT [GOC:mah]
synonym: "negative regulation of Wnt-activated signaling pathway involved in dorsal/ventral axis specification" EXACT [GOC:signaling]
is_a: GO:0030178 ! negative regulation of Wnt signaling pathway
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000053 ! regulation of Wnt signaling pathway involved in dorsal/ventral axis specification
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044332 ! Wnt signaling pathway involved in dorsal/ventral axis specification
relationship: negatively_regulates GO:0044332 ! Wnt signaling pathway involved in dorsal/ventral axis specification
created_by: jane
creation_date: 2010-08-20T01:13:35Z

[Term]
id: GO:2000055
name: positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of Wnt signaling pathway involved in dorsal/ventral axis specification." [GOC:obol]
synonym: "positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification" EXACT []
synonym: "positive regulation of Wnt receptor signalling pathway involved in dorsal/ventral axis specification" EXACT [GOC:mah]
synonym: "positive regulation of Wnt-activated signaling pathway involved in dorsal/ventral axis specification" EXACT [GOC:signaling]
is_a: GO:0030177 ! positive regulation of Wnt signaling pathway
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000053 ! regulation of Wnt signaling pathway involved in dorsal/ventral axis specification
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044332 ! Wnt signaling pathway involved in dorsal/ventral axis specification
relationship: positively_regulates GO:0044332 ! Wnt signaling pathway involved in dorsal/ventral axis specification
created_by: jane
creation_date: 2010-08-20T01:13:40Z

[Term]
id: GO:2000056
name: regulation of Wnt signaling pathway involved in digestive tract morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Wnt signaling pathway involved in digestive tract morphogenesis." [GOC:obol]
synonym: "regulation of Wnt receptor signaling pathway involved in digestive tract morphogenesis" EXACT []
synonym: "regulation of Wnt receptor signalling pathway involved in digestive tract morphogenesis" EXACT [GOC:mah]
synonym: "regulation of Wnt-activated signaling pathway involved in digestive tract morphogenesis" RELATED [GOC:signaling]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0030111 ! regulation of Wnt signaling pathway
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044333 ! Wnt signaling pathway involved in digestive tract morphogenesis
relationship: regulates GO:0044333 ! Wnt signaling pathway involved in digestive tract morphogenesis
created_by: jane
creation_date: 2010-08-20T01:17:27Z

[Term]
id: GO:2000057
name: negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Wnt signaling pathway involved in digestive tract morphogenesis." [GOC:obol]
synonym: "negative regulation of Wnt receptor signaling pathway involved in digestive tract morphogenesis" EXACT []
synonym: "negative regulation of Wnt receptor signalling pathway involved in digestive tract morphogenesis" EXACT [GOC:mah]
synonym: "negative regulation of Wnt-activated signaling pathway involved in digestive tract morphogenesis" EXACT [GOC:signaling]
is_a: GO:0030178 ! negative regulation of Wnt signaling pathway
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000056 ! regulation of Wnt signaling pathway involved in digestive tract morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044333 ! Wnt signaling pathway involved in digestive tract morphogenesis
relationship: negatively_regulates GO:0044333 ! Wnt signaling pathway involved in digestive tract morphogenesis
created_by: jane
creation_date: 2010-08-20T01:17:35Z

[Term]
id: GO:2000058
name: regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein ubiquitination involved in ubiquitin-dependent protein catabolic process." [GOC:BHF]
synonym: "regulation of myofibrillar protein ubiquitination during ubiquitin-dependent protein breakdown" RELATED [GOC:obol]
synonym: "regulation of myofibrillar protein ubiquitination during ubiquitin-dependent protein catabolic process" RELATED [GOC:obol]
synonym: "regulation of myofibrillar protein ubiquitination during ubiquitin-dependent protein catabolism" RELATED [GOC:obol]
synonym: "regulation of myofibrillar protein ubiquitination during ubiquitin-dependent protein degradation" RELATED [GOC:obol]
synonym: "regulation of protein degradation tagging activity" RELATED [GOC:obol]
synonym: "regulation of protein ubiquitination during ubiquitin-dependent protein breakdown" EXACT [GOC:obol]
synonym: "regulation of protein ubiquitination during ubiquitin-dependent protein catabolic process" RELATED [GOC:obol]
synonym: "regulation of protein ubiquitination during ubiquitin-dependent protein catabolism" EXACT [GOC:obol]
synonym: "regulation of protein ubiquitination during ubiquitin-dependent protein degradation" EXACT [GOC:obol]
synonym: "regulation of protein ubiquitinylation during ubiquitin-dependent protein catabolic process" EXACT [GOC:obol]
synonym: "regulation of protein ubiquitinylation during ubiquitin-dependent protein catabolism" EXACT [GOC:obol]
synonym: "regulation of protein ubiquitylation during ubiquitin-dependent protein catabolic process" EXACT [GOC:obol]
synonym: "regulation of protein ubiquitylation during ubiquitin-dependent protein catabolism" EXACT [GOC:obol]
is_a: GO:0031396 ! regulation of protein ubiquitination
is_a: GO:1903050 ! regulation of proteolysis involved in cellular protein catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042787 ! protein ubiquitination involved in ubiquitin-dependent protein catabolic process
relationship: regulates GO:0042787 ! protein ubiquitination involved in ubiquitin-dependent protein catabolic process
created_by: jane
creation_date: 2010-08-20T01:23:46Z

[Term]
id: GO:2000059
name: negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein ubiquitination involved in ubiquitin-dependent protein catabolic process." [GOC:BHF]
synonym: "negative regulation of myofibrillar protein ubiquitination during ubiquitin-dependent protein breakdown" RELATED [GOC:obol]
synonym: "negative regulation of myofibrillar protein ubiquitination during ubiquitin-dependent protein catabolic process" RELATED [GOC:obol]
synonym: "negative regulation of myofibrillar protein ubiquitination during ubiquitin-dependent protein catabolism" RELATED [GOC:obol]
synonym: "negative regulation of myofibrillar protein ubiquitination during ubiquitin-dependent protein degradation" RELATED [GOC:obol]
synonym: "negative regulation of protein degradation tagging activity" RELATED [GOC:obol]
synonym: "negative regulation of protein ubiquitination during ubiquitin-dependent protein breakdown" EXACT [GOC:obol]
synonym: "negative regulation of protein ubiquitination during ubiquitin-dependent protein catabolic process" RELATED [GOC:obol]
synonym: "negative regulation of protein ubiquitination during ubiquitin-dependent protein catabolism" EXACT [GOC:obol]
synonym: "negative regulation of protein ubiquitination during ubiquitin-dependent protein degradation" EXACT [GOC:obol]
synonym: "negative regulation of protein ubiquitinylation during ubiquitin-dependent protein catabolic process" EXACT [GOC:obol]
synonym: "negative regulation of protein ubiquitinylation during ubiquitin-dependent protein catabolism" EXACT [GOC:obol]
synonym: "negative regulation of protein ubiquitylation during ubiquitin-dependent protein catabolic process" EXACT [GOC:obol]
synonym: "negative regulation of protein ubiquitylation during ubiquitin-dependent protein catabolism" EXACT [GOC:obol]
is_a: GO:0031397 ! negative regulation of protein ubiquitination
is_a: GO:1903051 ! negative regulation of proteolysis involved in cellular protein catabolic process
is_a: GO:2000058 ! regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042787 ! protein ubiquitination involved in ubiquitin-dependent protein catabolic process
relationship: negatively_regulates GO:0042787 ! protein ubiquitination involved in ubiquitin-dependent protein catabolic process
created_by: jane
creation_date: 2010-08-20T01:23:56Z

[Term]
id: GO:2000060
name: positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein ubiquitination involved in ubiquitin-dependent protein catabolic process." [GOC:BHF]
synonym: "positive regulation of myofibrillar protein ubiquitination during ubiquitin-dependent protein breakdown" RELATED [GOC:obol]
synonym: "positive regulation of myofibrillar protein ubiquitination during ubiquitin-dependent protein catabolic process" RELATED [GOC:obol]
synonym: "positive regulation of myofibrillar protein ubiquitination during ubiquitin-dependent protein catabolism" RELATED [GOC:obol]
synonym: "positive regulation of myofibrillar protein ubiquitination during ubiquitin-dependent protein degradation" RELATED [GOC:obol]
synonym: "positive regulation of protein degradation tagging activity" RELATED [GOC:obol]
synonym: "positive regulation of protein ubiquitination during ubiquitin-dependent protein breakdown" EXACT [GOC:obol]
synonym: "positive regulation of protein ubiquitination during ubiquitin-dependent protein catabolic process" RELATED [GOC:obol]
synonym: "positive regulation of protein ubiquitination during ubiquitin-dependent protein catabolism" EXACT [GOC:obol]
synonym: "positive regulation of protein ubiquitination during ubiquitin-dependent protein degradation" EXACT [GOC:obol]
synonym: "positive regulation of protein ubiquitinylation during ubiquitin-dependent protein catabolic process" EXACT [GOC:obol]
synonym: "positive regulation of protein ubiquitinylation during ubiquitin-dependent protein catabolism" EXACT [GOC:obol]
synonym: "positive regulation of protein ubiquitylation during ubiquitin-dependent protein catabolic process" EXACT [GOC:obol]
synonym: "positive regulation of protein ubiquitylation during ubiquitin-dependent protein catabolism" EXACT [GOC:obol]
is_a: GO:0031398 ! positive regulation of protein ubiquitination
is_a: GO:1903052 ! positive regulation of proteolysis involved in cellular protein catabolic process
is_a: GO:2000058 ! regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042787 ! protein ubiquitination involved in ubiquitin-dependent protein catabolic process
relationship: positively_regulates GO:0042787 ! protein ubiquitination involved in ubiquitin-dependent protein catabolic process
created_by: jane
creation_date: 2010-08-20T01:24:03Z

[Term]
id: GO:2000061
name: regulation of ureter smooth muscle cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ureter smooth muscle cell differentiation." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf]
is_a: GO:0048634 ! regulation of muscle organ development
is_a: GO:0051150 ! regulation of smooth muscle cell differentiation
is_a: GO:1901861 ! regulation of muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072193 ! ureter smooth muscle cell differentiation
relationship: regulates GO:0072193 ! ureter smooth muscle cell differentiation
created_by: jane
creation_date: 2010-08-20T01:44:16Z

[Term]
id: GO:2000062
name: negative regulation of ureter smooth muscle cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ureter smooth muscle cell differentiation." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf]
is_a: GO:0051151 ! negative regulation of smooth muscle cell differentiation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1901862 ! negative regulation of muscle tissue development
is_a: GO:2000061 ! regulation of ureter smooth muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072193 ! ureter smooth muscle cell differentiation
relationship: negatively_regulates GO:0072193 ! ureter smooth muscle cell differentiation
created_by: jane
creation_date: 2010-08-20T01:44:23Z

[Term]
id: GO:2000063
name: positive regulation of ureter smooth muscle cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ureter smooth muscle cell differentiation." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf]
is_a: GO:0051152 ! positive regulation of smooth muscle cell differentiation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1901863 ! positive regulation of muscle tissue development
is_a: GO:2000061 ! regulation of ureter smooth muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072193 ! ureter smooth muscle cell differentiation
relationship: positively_regulates GO:0072193 ! ureter smooth muscle cell differentiation
created_by: jane
creation_date: 2010-08-20T01:44:28Z

[Term]
id: GO:2000064
name: regulation of cortisol biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cortisol biosynthetic process." [GOC:obol, GOC:yaf]
synonym: "regulation of cortisol anabolism" RELATED [GOC:obol]
synonym: "regulation of cortisol biosynthesis" EXACT [GOC:obol]
synonym: "regulation of cortisol formation" EXACT [GOC:obol]
synonym: "regulation of cortisol synthesis" EXACT [GOC:obol]
is_a: GO:0010566 ! regulation of ketone biosynthetic process
is_a: GO:0031946 ! regulation of glucocorticoid biosynthetic process
is_a: GO:1902930 ! regulation of alcohol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034651 ! cortisol biosynthetic process
relationship: regulates GO:0034651 ! cortisol biosynthetic process
created_by: jane
creation_date: 2010-08-20T01:51:15Z

[Term]
id: GO:2000065
name: negative regulation of cortisol biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cortisol biosynthetic process." [GOC:obol, GOC:yaf]
synonym: "negative regulation of cortisol anabolism" RELATED [GOC:obol]
synonym: "negative regulation of cortisol biosynthesis" EXACT [GOC:obol]
synonym: "negative regulation of cortisol formation" EXACT [GOC:obol]
synonym: "negative regulation of cortisol synthesis" EXACT [GOC:obol]
is_a: GO:0031947 ! negative regulation of glucocorticoid biosynthetic process
is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process
is_a: GO:2000064 ! regulation of cortisol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034651 ! cortisol biosynthetic process
relationship: negatively_regulates GO:0034651 ! cortisol biosynthetic process
created_by: jane
creation_date: 2010-08-20T01:51:23Z

[Term]
id: GO:2000066
name: positive regulation of cortisol biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cortisol biosynthetic process." [GOC:obol, GOC:yaf]
synonym: "positive regulation of cortisol anabolism" RELATED [GOC:obol]
synonym: "positive regulation of cortisol biosynthesis" EXACT [GOC:obol]
synonym: "positive regulation of cortisol formation" EXACT [GOC:obol]
synonym: "positive regulation of cortisol synthesis" EXACT [GOC:obol]
is_a: GO:0031948 ! positive regulation of glucocorticoid biosynthetic process
is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process
is_a: GO:2000064 ! regulation of cortisol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034651 ! cortisol biosynthetic process
relationship: positively_regulates GO:0034651 ! cortisol biosynthetic process
created_by: jane
creation_date: 2010-08-20T01:51:32Z

[Term]
id: GO:2000067
name: regulation of root morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of root morphogenesis." [GOC:obol]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:2000280 ! regulation of root development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010015 ! root morphogenesis
relationship: regulates GO:0010015 ! root morphogenesis
created_by: tanyaberardini
creation_date: 2010-08-23T09:25:13Z

[Term]
id: GO:2000068
name: regulation of defense response to insect
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of defense response to insect." [GOC:obol]
synonym: "regulation of physiological defense response to insect" EXACT [GOC:obol]
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0032101 ! regulation of response to external stimulus
is_a: GO:0043900 ! regulation of multi-organism process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002213 ! defense response to insect
relationship: regulates GO:0002213 ! defense response to insect
created_by: tanyaberardini
creation_date: 2010-08-23T09:30:00Z

[Term]
id: GO:2000069
name: regulation of post-embryonic root development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of post-embryonic root development." [GOC:obol]
is_a: GO:0048580 ! regulation of post-embryonic development
is_a: GO:2000280 ! regulation of root development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048528 ! post-embryonic root development
relationship: regulates GO:0048528 ! post-embryonic root development
created_by: tanyaberardini
creation_date: 2010-08-23T11:31:32Z

[Term]
id: GO:2000070
name: regulation of response to water deprivation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to water deprivation." [GOC:obol]
synonym: "regulation of drought tolerance" RELATED [GOC:obol]
synonym: "regulation of response to dehydration" EXACT [GOC:obol]
synonym: "regulation of response to drought" EXACT [GOC:obol]
synonym: "regulation of response to thirst" EXACT [GOC:obol]
is_a: GO:0080134 ! regulation of response to stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009414 ! response to water deprivation
relationship: regulates GO:0009414 ! response to water deprivation
created_by: tanyaberardini
creation_date: 2010-08-23T11:32:32Z

[Term]
id: GO:2000071
name: regulation of defense response by callose deposition
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of defense response by callose deposition." [GOC:obol]
synonym: "regulation of callose deposition during defense response" RELATED [GOC:obol]
synonym: "regulation of callose localization during defense response" RELATED [GOC:obol]
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0032879 ! regulation of localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0052542 ! defense response by callose deposition
relationship: regulates GO:0052542 ! defense response by callose deposition
created_by: tanyaberardini
creation_date: 2010-08-23T11:34:01Z

[Term]
id: GO:2000072
name: regulation of defense response to fungus, incompatible interaction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of defense response to fungus, incompatible interaction." [GOC:obol]
synonym: "regulation of defence response to fungus, incompatible interaction" EXACT [GOC:obol]
synonym: "regulation of defence response to pathogenic fungi, incompatible interaction" EXACT [GOC:obol]
synonym: "regulation of defence response to pathogenic fungus, incompatible interaction" EXACT [GOC:obol]
synonym: "regulation of defense response to fungi, incompatible interaction" EXACT [GOC:obol]
synonym: "regulation of resistance response to pathogenic fungi" EXACT [GOC:obol]
synonym: "regulation of resistance response to pathogenic fungus" EXACT [GOC:obol]
synonym: "regulation of response to pathogenic fungi (incompatible interaction)" EXACT [GOC:obol]
synonym: "regulation of response to pathogenic fungus (incompatible interaction)" EXACT [GOC:obol]
is_a: GO:0045088 ! regulation of innate immune response
is_a: GO:1900150 ! regulation of defense response to fungus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009817 ! defense response to fungus, incompatible interaction
relationship: regulates GO:0009817 ! defense response to fungus, incompatible interaction
created_by: tanyaberardini
creation_date: 2010-08-23T11:34:52Z

[Term]
id: GO:2000073
name: regulation of cytokinesis, site selection
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of site selection that occurs as part of cytokinesis." [GOC:mtg_cell_cycle, GOC:obol]
synonym: "regulation of site selection involved in cell cycle cytokinesis" EXACT []
is_a: GO:0032954 ! regulation of cytokinetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007105 ! cytokinesis, site selection
relationship: regulates GO:0007105 ! cytokinesis, site selection
created_by: tanyaberardini
creation_date: 2010-08-27T11:15:15Z

[Term]
id: GO:2000074
name: regulation of type B pancreatic cell development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pancreatic B cell development." [GOC:obol, GOC:yaf]
synonym: "regulation of pancreatic B cell development" EXACT [GOC:mah]
synonym: "regulation of pancreatic beta cell development" EXACT [GOC:obol]
is_a: GO:0030856 ! regulation of epithelial cell differentiation
is_a: GO:0060284 ! regulation of cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003323 ! type B pancreatic cell development
relationship: regulates GO:0003323 ! type B pancreatic cell development
created_by: tanyaberardini
creation_date: 2010-08-27T11:19:37Z

[Term]
id: GO:2000075
name: negative regulation of cytokinesis, site selection
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of site selection that occurs as part of cytokinesis." [GOC:mtg_cell_cycle, GOC:obol]
synonym: "negative regulation of site selection involved in cell cycle cytokinesis" EXACT []
is_a: GO:0032466 ! negative regulation of cytokinesis
is_a: GO:2000073 ! regulation of cytokinesis, site selection
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007105 ! cytokinesis, site selection
relationship: negatively_regulates GO:0007105 ! cytokinesis, site selection
created_by: tanyaberardini
creation_date: 2010-08-27T11:19:56Z

[Term]
id: GO:2000076
name: positive regulation cytokinesis, site selection
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of site selection that occurs as part of cytokinesis." [GOC:mtg_cell_cycle, GOC:obol]
synonym: "positive regulation of site selection involved in cell cycle cytokinesis" EXACT []
is_a: GO:0032467 ! positive regulation of cytokinesis
is_a: GO:2000073 ! regulation of cytokinesis, site selection
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007105 ! cytokinesis, site selection
relationship: positively_regulates GO:0007105 ! cytokinesis, site selection
created_by: tanyaberardini
creation_date: 2010-08-27T11:19:58Z

[Term]
id: GO:2000077
name: negative regulation of type B pancreatic cell development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic B cell development." [GOC:obol, GOC:yaf]
synonym: "negative regulation of pancreatic B cell development" EXACT [GOC:mah]
synonym: "negative regulation of pancreatic beta cell development" EXACT [GOC:obol]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0030857 ! negative regulation of epithelial cell differentiation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000074 ! regulation of type B pancreatic cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003323 ! type B pancreatic cell development
relationship: negatively_regulates GO:0003323 ! type B pancreatic cell development
created_by: tanyaberardini
creation_date: 2010-08-27T11:21:17Z

[Term]
id: GO:2000078
name: positive regulation of type B pancreatic cell development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pancreatic B cell development." [GOC:obol, GOC:yaf]
synonym: "positive regulation of pancreatic B cell development" EXACT [GOC:mah]
synonym: "positive regulation of pancreatic beta cell development" EXACT [GOC:obol]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0030858 ! positive regulation of epithelial cell differentiation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000074 ! regulation of type B pancreatic cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003323 ! type B pancreatic cell development
relationship: positively_regulates GO:0003323 ! type B pancreatic cell development
created_by: tanyaberardini
creation_date: 2010-08-27T11:21:19Z

[Term]
id: GO:2000079
name: regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of canonical Wnt signaling pathway modulating the rate or frequency of pancreatic B cell proliferation." [GOC:obol, GOC:yaf]
synonym: "regulation of canonical Wnt receptor signaling pathway involved in controlling pancreatic B cell proliferation" EXACT [GOC:mah]
synonym: "regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation" EXACT []
synonym: "regulation of canonical Wnt receptor signaling pathway involved in pancreatic beta cell proliferation" EXACT [GOC:obol]
synonym: "regulation of canonical Wnt receptor signalling pathway involved in controlling pancreatic B cell proliferation" EXACT [GOC:mah]
synonym: "regulation of canonical Wnt receptor signalling pathway involved in controlling type B pancreatic cell proliferation" EXACT [GOC:mah]
synonym: "regulation of canonical Wnt-activated signaling pathway involved in controlling type B pancreatic cell proliferation" EXACT [GOC:signaling]
is_a: GO:0060828 ! regulation of canonical Wnt signaling pathway
is_a: GO:0061469 ! regulation of type B pancreatic cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044343 ! canonical Wnt signaling pathway involved in regulation of type B pancreatic cell proliferation
relationship: regulates GO:0044343 ! canonical Wnt signaling pathway involved in regulation of type B pancreatic cell proliferation
created_by: tanyaberardini
creation_date: 2010-08-27T11:22:56Z

[Term]
id: GO:2000080
name: negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of canonical Wnt signaling pathway modulating the rate or frequency of pancreatic B cell proliferation." [GOC:obol, GOC:yaf]
synonym: "negative regulation of canonical Wnt receptor signaling pathway involved in controlling pancreatic B cell proliferation" EXACT [GOC:mah]
synonym: "negative regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation" EXACT []
synonym: "negative regulation of canonical Wnt receptor signaling pathway involved in pancreatic beta cell proliferation" EXACT [GOC:obol]
synonym: "negative regulation of canonical Wnt receptor signalling pathway involved in controlling pancreatic B cell proliferation" EXACT [GOC:mah]
synonym: "negative regulation of canonical Wnt receptor signalling pathway involved in controlling type B pancreatic cell proliferation" EXACT [GOC:mah]
synonym: "negative regulation of canonical Wnt-activated signaling pathway involved in controlling type B pancreatic cell proliferation" EXACT [GOC:signaling]
is_a: GO:0008285 ! negative regulation of cell proliferation
is_a: GO:0090090 ! negative regulation of canonical Wnt signaling pathway
is_a: GO:2000079 ! regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044343 ! canonical Wnt signaling pathway involved in regulation of type B pancreatic cell proliferation
relationship: negatively_regulates GO:0044343 ! canonical Wnt signaling pathway involved in regulation of type B pancreatic cell proliferation
created_by: tanyaberardini
creation_date: 2010-08-27T11:22:58Z

[Term]
id: GO:2000081
name: positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of canonical Wnt signaling pathway modulating the rate or frequency of pancreatic B cell proliferation." [GOC:obol, GOC:yaf]
synonym: "positive regulation of canonical Wnt receptor signaling pathway involved in controlling pancreatic B cell proliferation" EXACT [GOC:mah]
synonym: "positive regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation" EXACT []
synonym: "positive regulation of canonical Wnt receptor signaling pathway involved in pancreatic beta cell proliferation" EXACT [GOC:obol]
synonym: "positive regulation of canonical Wnt receptor signalling pathway involved in controlling pancreatic B cell proliferation" EXACT [GOC:mah]
synonym: "positive regulation of canonical Wnt receptor signalling pathway involved in controlling type B pancreatic cell proliferation" EXACT [GOC:mah]
synonym: "positive regulation of canonical Wnt-activated signaling pathway involved in controlling type B pancreatic cell proliferation" EXACT [GOC:signaling]
is_a: GO:0008284 ! positive regulation of cell proliferation
is_a: GO:0090263 ! positive regulation of canonical Wnt signaling pathway
is_a: GO:2000079 ! regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044343 ! canonical Wnt signaling pathway involved in regulation of type B pancreatic cell proliferation
relationship: positively_regulates GO:0044343 ! canonical Wnt signaling pathway involved in regulation of type B pancreatic cell proliferation
created_by: tanyaberardini
creation_date: 2010-08-27T11:23:00Z

[Term]
id: GO:2000082
name: regulation of L-ascorbic acid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of L-ascorbic acid biosynthetic process." [PMID:19395407]
synonym: "regulation of ascorbate biosynthesis" EXACT [GOC:obol]
synonym: "regulation of ascorbate biosynthetic process" EXACT [GOC:obol]
synonym: "regulation of L-ascorbic acid anabolism" EXACT [GOC:obol]
synonym: "regulation of L-ascorbic acid biosynthesis" EXACT [GOC:obol]
synonym: "regulation of L-ascorbic acid formation" EXACT [GOC:obol]
synonym: "regulation of L-ascorbic acid synthesis" EXACT [GOC:obol]
synonym: "regulation of vitamin C biosynthesis" EXACT [GOC:obol]
synonym: "regulation of vitamin C biosynthetic process" EXACT [GOC:obol]
is_a: GO:0010565 ! regulation of cellular ketone metabolic process
is_a: GO:0030656 ! regulation of vitamin metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019853 ! L-ascorbic acid biosynthetic process
relationship: regulates GO:0019853 ! L-ascorbic acid biosynthetic process
created_by: tanyaberardini
creation_date: 2010-08-27T11:26:16Z

[Term]
id: GO:2000083
name: negative regulation of L-ascorbic acid biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of L-ascorbic acid biosynthetic process." [PMID:19395407]
synonym: "negative regulation of ascorbate biosynthesis" EXACT [GOC:obol]
synonym: "negative regulation of ascorbate biosynthetic process" EXACT [GOC:obol]
synonym: "negative regulation of L-ascorbic acid anabolism" EXACT [GOC:obol]
synonym: "negative regulation of L-ascorbic acid biosynthesis" EXACT [GOC:obol]
synonym: "negative regulation of L-ascorbic acid formation" EXACT [GOC:obol]
synonym: "negative regulation of L-ascorbic acid synthesis" EXACT [GOC:obol]
synonym: "negative regulation of vitamin C biosynthesis" EXACT [GOC:obol]
synonym: "negative regulation of vitamin C biosynthetic process" EXACT [GOC:obol]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:0046137 ! negative regulation of vitamin metabolic process
is_a: GO:2000082 ! regulation of L-ascorbic acid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019853 ! L-ascorbic acid biosynthetic process
relationship: negatively_regulates GO:0019853 ! L-ascorbic acid biosynthetic process
created_by: tanyaberardini
creation_date: 2010-08-27T11:26:19Z

[Term]
id: GO:2000084
name: regulation of mesenchymal to epithelial transition involved in mesonephros morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesenchymal to epithelial transition involved in mesonephros morphogenesis." [GOC:mtg_kidney_jan10]
synonym: "regulation of mesonephric mesenchyme to epithelial transition" RELATED [GOC:obol]
is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation
is_a: GO:0030856 ! regulation of epithelial cell differentiation
is_a: GO:0061217 ! regulation of mesonephros development
is_a: GO:2000027 ! regulation of organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061261 ! mesenchymal to epithelial transition involved in mesonephros morphogenesis
relationship: regulates GO:0061261 ! mesenchymal to epithelial transition involved in mesonephros morphogenesis
created_by: dph
creation_date: 2010-09-03T06:06:41Z

[Term]
id: GO:2000085
name: negative regulation of mesenchymal to epithelial transition involved in mesonephros morphogenesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mesenchymal to epithelial transition involved in mesonephros morphogenesis." [GOC:mtg_kidney_jan10]
synonym: "negative regulation of mesonephric mesenchyme to epithelial transition" RELATED [GOC:obol]
is_a: GO:0010771 ! negative regulation of cell morphogenesis involved in differentiation
is_a: GO:0030857 ! negative regulation of epithelial cell differentiation
is_a: GO:0061218 ! negative regulation of mesonephros development
is_a: GO:2000084 ! regulation of mesenchymal to epithelial transition involved in mesonephros morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061261 ! mesenchymal to epithelial transition involved in mesonephros morphogenesis
relationship: negatively_regulates GO:0061261 ! mesenchymal to epithelial transition involved in mesonephros morphogenesis
created_by: dph
creation_date: 2010-09-03T06:08:21Z

[Term]
id: GO:2000086
name: positive regulation of mesenchymal to epithelial transition involved in mesonephros morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mesenchymal to epithelial transition involved in mesonephros morphogenesis." [GOC:mtg_kidney_jan10]
synonym: "positive regulation of mesonephric mesenchyme to epithelial transition" RELATED [GOC:obol]
is_a: GO:0010770 ! positive regulation of cell morphogenesis involved in differentiation
is_a: GO:0030858 ! positive regulation of epithelial cell differentiation
is_a: GO:0061213 ! positive regulation of mesonephros development
is_a: GO:2000084 ! regulation of mesenchymal to epithelial transition involved in mesonephros morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061261 ! mesenchymal to epithelial transition involved in mesonephros morphogenesis
relationship: positively_regulates GO:0061261 ! mesenchymal to epithelial transition involved in mesonephros morphogenesis
created_by: dph
creation_date: 2010-09-03T06:08:24Z

[Term]
id: GO:2000087
name: regulation of mesonephric glomerulus development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesonephric glomerulus development." [GOC:mtg_kidney_jan10]
is_a: GO:0061217 ! regulation of mesonephros development
is_a: GO:0090192 ! regulation of glomerulus development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061224 ! mesonephric glomerulus development
relationship: regulates GO:0061224 ! mesonephric glomerulus development
created_by: dph
creation_date: 2010-09-03T06:09:19Z

[Term]
id: GO:2000088
name: negative regulation of mesonephric glomerulus development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mesonephric glomerulus development." [GOC:mtg_kidney_jan10]
is_a: GO:0061218 ! negative regulation of mesonephros development
is_a: GO:0090194 ! negative regulation of glomerulus development
is_a: GO:2000087 ! regulation of mesonephric glomerulus development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061224 ! mesonephric glomerulus development
relationship: negatively_regulates GO:0061224 ! mesonephric glomerulus development
created_by: dph
creation_date: 2010-09-03T06:09:22Z

[Term]
id: GO:2000089
name: positive regulation of mesonephric glomerulus development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mesonephric glomerulus development." [GOC:mtg_kidney_jan10]
is_a: GO:0061213 ! positive regulation of mesonephros development
is_a: GO:0090193 ! positive regulation of glomerulus development
is_a: GO:2000087 ! regulation of mesonephric glomerulus development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061224 ! mesonephric glomerulus development
relationship: positively_regulates GO:0061224 ! mesonephric glomerulus development
created_by: dph
creation_date: 2010-09-03T06:09:24Z

[Term]
id: GO:2000090
name: regulation of mesonephric glomerular mesangial cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesonephric glomerular mesangial cell proliferation." [GOC:mtg_kidney_jan10]
is_a: GO:0072124 ! regulation of glomerular mesangial cell proliferation
is_a: GO:2000087 ! regulation of mesonephric glomerulus development
is_a: GO:2000606 ! regulation of cell proliferation involved in mesonephros development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061269 ! mesonephric glomerular mesangial cell proliferation involved in mesonephros development
relationship: regulates GO:0061269 ! mesonephric glomerular mesangial cell proliferation involved in mesonephros development
created_by: dph
creation_date: 2010-09-03T06:10:28Z

[Term]
id: GO:2000091
name: negative regulation of mesonephric glomerular mesangial cell proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mesonephric glomerular mesangial cell proliferation." [GOC:mtg_kidney_jan10]
is_a: GO:0072125 ! negative regulation of glomerular mesangial cell proliferation
is_a: GO:2000088 ! negative regulation of mesonephric glomerulus development
is_a: GO:2000090 ! regulation of mesonephric glomerular mesangial cell proliferation
is_a: GO:2000607 ! negative regulation of cell proliferation involved in mesonephros development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061269 ! mesonephric glomerular mesangial cell proliferation involved in mesonephros development
relationship: negatively_regulates GO:0061269 ! mesonephric glomerular mesangial cell proliferation involved in mesonephros development
created_by: dph
creation_date: 2010-09-03T06:10:31Z

[Term]
id: GO:2000092
name: positive regulation of mesonephric glomerular mesangial cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mesonephric glomerular mesangial cell proliferation." [GOC:mtg_kidney_jan10]
is_a: GO:0072126 ! positive regulation of glomerular mesangial cell proliferation
is_a: GO:2000089 ! positive regulation of mesonephric glomerulus development
is_a: GO:2000090 ! regulation of mesonephric glomerular mesangial cell proliferation
is_a: GO:2000608 ! positive regulation of cell proliferation involved in mesonephros development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061269 ! mesonephric glomerular mesangial cell proliferation involved in mesonephros development
relationship: positively_regulates GO:0061269 ! mesonephric glomerular mesangial cell proliferation involved in mesonephros development
created_by: dph
creation_date: 2010-09-03T06:10:33Z

[Term]
id: GO:2000093
name: regulation of mesonephric nephron tubule epithelial cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesonephric nephron tubule epithelial cell differentiation." [GOC:mtg_kidney_jan10]
is_a: GO:0061217 ! regulation of mesonephros development
is_a: GO:0072182 ! regulation of nephron tubule epithelial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061265 ! mesonephric nephron tubule epithelial cell differentiation
relationship: regulates GO:0061265 ! mesonephric nephron tubule epithelial cell differentiation
created_by: dph
creation_date: 2010-09-03T06:12:25Z

[Term]
id: GO:2000094
name: negative regulation of mesonephric nephron tubule epithelial cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mesonephric nephron tubule epithelial cell differentiation." [GOC:mtg_kidney_jan10]
is_a: GO:0061218 ! negative regulation of mesonephros development
is_a: GO:0072183 ! negative regulation of nephron tubule epithelial cell differentiation
is_a: GO:2000093 ! regulation of mesonephric nephron tubule epithelial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061265 ! mesonephric nephron tubule epithelial cell differentiation
relationship: negatively_regulates GO:0061265 ! mesonephric nephron tubule epithelial cell differentiation
created_by: dph
creation_date: 2010-09-03T06:12:28Z

[Term]
id: GO:2000095
name: regulation of Wnt signaling pathway, planar cell polarity pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Wnt signaling pathway, planar cell polarity pathway." [GOC:BHF]
synonym: "regulation of non-canonical Wnt signaling pathway" RELATED [GOC:obol]
synonym: "regulation of PCP pathway" EXACT [GOC:obol]
synonym: "regulation of Wnt receptor signaling pathway, planar cell polarity pathway" EXACT []
synonym: "regulation of Wnt receptor signalling pathway, planar cell polarity pathway" EXACT [GOC:obol]
synonym: "regulation of Wnt-activated signaling pathway, planar cell polarity pathway" EXACT [GOC:signaling]
synonym: "regulation of Wnt-JNK signaling pathway" RELATED [GOC:obol]
synonym: "regulation of Wnt-PCP signaling pathway" RELATED [GOC:obol]
is_a: GO:0090175 ! regulation of establishment of planar polarity
is_a: GO:2000050 ! regulation of non-canonical Wnt signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway
relationship: regulates GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway
created_by: jane
creation_date: 2010-09-08T01:07:39Z

[Term]
id: GO:2000096
name: positive regulation of Wnt signaling pathway, planar cell polarity pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of Wnt signaling pathway, planar cell polarity pathway." [GOC:BHF]
synonym: "positive regulation of non-canonical Wnt signaling pathway" RELATED [GOC:obol]
synonym: "positive regulation of PCP pathway" EXACT [GOC:obol]
synonym: "positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway" EXACT []
synonym: "positive regulation of Wnt receptor signalling pathway, planar cell polarity pathway" EXACT [GOC:obol]
synonym: "positive regulation of Wnt-activated signaling pathway, planar cell polarity pathway" EXACT [GOC:signaling]
synonym: "positive regulation of Wnt-JNK signaling pathway" RELATED [GOC:obol]
synonym: "positive regulation of Wnt-PCP signaling pathway" RELATED [GOC:obol]
is_a: GO:2000052 ! positive regulation of non-canonical Wnt signaling pathway
is_a: GO:2000095 ! regulation of Wnt signaling pathway, planar cell polarity pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway
relationship: positively_regulates GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway
created_by: jane
creation_date: 2010-09-08T01:07:42Z

[Term]
id: GO:2000097
name: regulation of smooth muscle cell-matrix adhesion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of smooth muscle cell-matrix adhesion." [GOC:BHF]
is_a: GO:0001952 ! regulation of cell-matrix adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061302 ! smooth muscle cell-matrix adhesion
relationship: regulates GO:0061302 ! smooth muscle cell-matrix adhesion
created_by: dph
creation_date: 2010-09-14T04:22:20Z

[Term]
id: GO:2000098
name: negative regulation of smooth muscle cell-matrix adhesion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell-matrix adhesion." [GOC:BHF]
is_a: GO:0001953 ! negative regulation of cell-matrix adhesion
is_a: GO:2000097 ! regulation of smooth muscle cell-matrix adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061302 ! smooth muscle cell-matrix adhesion
relationship: negatively_regulates GO:0061302 ! smooth muscle cell-matrix adhesion
created_by: dph
creation_date: 2010-09-14T04:22:22Z

[Term]
id: GO:2000099
name: regulation of establishment or maintenance of bipolar cell polarity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of establishment or maintenance of bipolar cell polarity." [GOC:obol]
is_a: GO:0032878 ! regulation of establishment or maintenance of cell polarity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061245 ! establishment or maintenance of bipolar cell polarity
relationship: regulates GO:0061245 ! establishment or maintenance of bipolar cell polarity
created_by: dph
creation_date: 2010-09-14T04:40:51Z

[Term]
id: GO:2000100
name: regulation of establishment or maintenance of bipolar cell polarity regulating cell shape
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of establishment or maintenance of bipolar cell polarity regulating cell shape." [GOC:obol]
is_a: GO:2000099 ! regulation of establishment or maintenance of bipolar cell polarity
is_a: GO:2000769 ! regulation of establishment or maintenance of cell polarity regulating cell shape
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061246 ! establishment or maintenance of bipolar cell polarity regulating cell shape
relationship: regulates GO:0061246 ! establishment or maintenance of bipolar cell polarity regulating cell shape
created_by: dph
creation_date: 2010-09-14T04:44:57Z

[Term]
id: GO:2000101
name: regulation of mammary stem cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mammary stem cell proliferation." [GOC:obol]
is_a: GO:0042127 ! regulation of cell proliferation
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002174 ! mammary stem cell proliferation
relationship: regulates GO:0002174 ! mammary stem cell proliferation
created_by: dph
creation_date: 2010-09-14T06:10:32Z

[Term]
id: GO:2000102
name: negative regulation of mammary stem cell proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mammary stem cell proliferation." [GOC:obol]
is_a: GO:0008285 ! negative regulation of cell proliferation
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000101 ! regulation of mammary stem cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002174 ! mammary stem cell proliferation
relationship: negatively_regulates GO:0002174 ! mammary stem cell proliferation
created_by: dph
creation_date: 2010-09-14T06:10:34Z

[Term]
id: GO:2000103
name: positive regulation of mammary stem cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mammary stem cell proliferation." [GOC:obol]
is_a: GO:0008284 ! positive regulation of cell proliferation
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000101 ! regulation of mammary stem cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002174 ! mammary stem cell proliferation
relationship: positively_regulates GO:0002174 ! mammary stem cell proliferation
created_by: dph
creation_date: 2010-09-14T06:10:36Z

[Term]
id: GO:2000104
name: negative regulation of DNA-dependent DNA replication
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent DNA replication." [GOC:mah]
is_a: GO:0008156 ! negative regulation of DNA replication
is_a: GO:0090329 ! regulation of DNA-dependent DNA replication
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006261 ! DNA-dependent DNA replication
relationship: negatively_regulates GO:0006261 ! DNA-dependent DNA replication
created_by: midori
creation_date: 2010-09-15T01:37:05Z

[Term]
id: GO:2000105
name: positive regulation of DNA-dependent DNA replication
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA-dependent DNA replication." [GOC:mah]
is_a: GO:0045740 ! positive regulation of DNA replication
is_a: GO:0090329 ! regulation of DNA-dependent DNA replication
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006261 ! DNA-dependent DNA replication
relationship: positively_regulates GO:0006261 ! DNA-dependent DNA replication
created_by: midori
creation_date: 2010-09-15T01:37:10Z

[Term]
id: GO:2000106
name: regulation of leukocyte apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of leukocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis]
synonym: "regulation of leukocyte apoptosis" NARROW []
is_a: GO:0042981 ! regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071887 ! leukocyte apoptotic process
relationship: regulates GO:0071887 ! leukocyte apoptotic process
created_by: midori
creation_date: 2010-09-15T01:42:05Z

[Term]
id: GO:2000107
name: negative regulation of leukocyte apoptotic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis]
synonym: "negative regulation of leukocyte apoptosis" NARROW []
is_a: GO:0043066 ! negative regulation of apoptotic process
is_a: GO:2000106 ! regulation of leukocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071887 ! leukocyte apoptotic process
relationship: negatively_regulates GO:0071887 ! leukocyte apoptotic process
created_by: midori
creation_date: 2010-09-15T01:42:09Z

[Term]
id: GO:2000108
name: positive regulation of leukocyte apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of leukocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis]
synonym: "positive regulation of leukocyte apoptosis" NARROW []
is_a: GO:0043065 ! positive regulation of apoptotic process
is_a: GO:2000106 ! regulation of leukocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071887 ! leukocyte apoptotic process
relationship: positively_regulates GO:0071887 ! leukocyte apoptotic process
created_by: midori
creation_date: 2010-09-15T01:42:12Z

[Term]
id: GO:2000109
name: regulation of macrophage apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of macrophage apoptotic process." [GOC:BHF, GOC:mtg_apoptosis]
synonym: "regulation of activation-induced cell death" RELATED [GOC:yaf]
synonym: "regulation of AICD" RELATED [GOC:yaf]
synonym: "regulation of macrophage apoptosis" NARROW []
is_a: GO:0033032 ! regulation of myeloid cell apoptotic process
is_a: GO:2000106 ! regulation of leukocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071888 ! macrophage apoptotic process
relationship: regulates GO:0071888 ! macrophage apoptotic process
created_by: midori
creation_date: 2010-09-15T01:44:15Z

[Term]
id: GO:2000110
name: negative regulation of macrophage apoptotic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage apoptotic process." [GOC:BHF, GOC:mtg_apoptosis]
synonym: "negative regulation of activation-induced cell death" RELATED [GOC:yaf]
synonym: "negative regulation of AICD" RELATED [GOC:yaf]
synonym: "negative regulation of macrophage apoptosis" NARROW []
is_a: GO:0033033 ! negative regulation of myeloid cell apoptotic process
is_a: GO:2000107 ! negative regulation of leukocyte apoptotic process
is_a: GO:2000109 ! regulation of macrophage apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071888 ! macrophage apoptotic process
relationship: negatively_regulates GO:0071888 ! macrophage apoptotic process
created_by: midori
creation_date: 2010-09-15T01:44:18Z

[Term]
id: GO:2000111
name: positive regulation of macrophage apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of macrophage apoptotic process." [GOC:BHF, GOC:mtg_apoptosis]
synonym: "positive regulation of activation-induced cell death" RELATED [GOC:yaf]
synonym: "positive regulation of AICD" RELATED [GOC:yaf]
synonym: "positive regulation of macrophage apoptosis" NARROW []
is_a: GO:0033034 ! positive regulation of myeloid cell apoptotic process
is_a: GO:2000108 ! positive regulation of leukocyte apoptotic process
is_a: GO:2000109 ! regulation of macrophage apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071888 ! macrophage apoptotic process
relationship: positively_regulates GO:0071888 ! macrophage apoptotic process
created_by: midori
creation_date: 2010-09-15T01:44:21Z

[Term]
id: GO:2000112
name: regulation of cellular macromolecule biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular macromolecule biosynthetic process." [GOC:obol]
synonym: "regulation of cellular biopolymer biosynthetic process" EXACT [GOC:obol]
synonym: "regulation of cellular macromolecule anabolism" EXACT [GOC:obol]
synonym: "regulation of cellular macromolecule biosynthesis" EXACT [GOC:obol]
synonym: "regulation of cellular macromolecule formation" EXACT [GOC:obol]
synonym: "regulation of cellular macromolecule synthesis" EXACT [GOC:obol]
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034645 ! cellular macromolecule biosynthetic process
relationship: regulates GO:0034645 ! cellular macromolecule biosynthetic process
created_by: tanyaberardini
creation_date: 2010-09-15T08:55:45Z

[Term]
id: GO:2000113
name: negative regulation of cellular macromolecule biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular macromolecule biosynthetic process." [GOC:obol]
synonym: "negative regulation of cellular biopolymer biosynthetic process" EXACT [GOC:obol]
synonym: "negative regulation of cellular macromolecule anabolism" EXACT [GOC:obol]
synonym: "negative regulation of cellular macromolecule biosynthesis" EXACT [GOC:obol]
synonym: "negative regulation of cellular macromolecule formation" EXACT [GOC:obol]
synonym: "negative regulation of cellular macromolecule synthesis" EXACT [GOC:obol]
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034645 ! cellular macromolecule biosynthetic process
relationship: negatively_regulates GO:0034645 ! cellular macromolecule biosynthetic process
created_by: tanyaberardini
creation_date: 2010-09-15T08:55:48Z

[Term]
id: GO:2000114
name: regulation of establishment of cell polarity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of establishment of cell polarity." [GOC:dph]
synonym: "regulation of bud site selection/establishment of cell polarity" RELATED [GOC:obol]
synonym: "regulation of cell polarization" EXACT [GOC:obol]
is_a: GO:0032878 ! regulation of establishment or maintenance of cell polarity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030010 ! establishment of cell polarity
relationship: regulates GO:0030010 ! establishment of cell polarity
created_by: dph
creation_date: 2010-09-16T01:22:36Z

[Term]
id: GO:2000115
name: regulation of maintenance of bipolar cell polarity regulating cell shape
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of maintenance of bipolar cell polarity regulating in cell shape." [GOC:obol]
is_a: GO:2000100 ! regulation of establishment or maintenance of bipolar cell polarity regulating cell shape
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061305 ! maintenance of bipolar cell polarity regulating cell shape
relationship: regulates GO:0061305 ! maintenance of bipolar cell polarity regulating cell shape
created_by: dph
creation_date: 2010-09-21T06:33:26Z

[Term]
id: GO:2000116
name: regulation of cysteine-type endopeptidase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cysteine-type endopeptidase activity." [GOC:obol, GOC:yaf]
synonym: "regulation of lysosomal cysteine-type endopeptidase" RELATED [GOC:obol]
synonym: "regulation of thiol endopeptidase activity" EXACT [GOC:obol]
is_a: GO:0052548 ! regulation of endopeptidase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004197 ! cysteine-type endopeptidase activity
relationship: regulates GO:0004197 ! cysteine-type endopeptidase activity
created_by: jane
creation_date: 2010-09-23T10:24:33Z

[Term]
id: GO:2000117
name: negative regulation of cysteine-type endopeptidase activity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cysteine-type endopeptidase activity." [GOC:obol, GOC:yaf]
synonym: "negative regulation of lysosomal cysteine-type endopeptidase" RELATED [GOC:obol]
synonym: "negative regulation of thiol endopeptidase activity" EXACT [GOC:obol]
is_a: GO:0010951 ! negative regulation of endopeptidase activity
is_a: GO:2000116 ! regulation of cysteine-type endopeptidase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004197 ! cysteine-type endopeptidase activity
relationship: negatively_regulates GO:0004197 ! cysteine-type endopeptidase activity
created_by: jane
creation_date: 2010-09-23T10:24:35Z

[Term]
id: GO:2000118
name: regulation of sodium-dependent phosphate transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sodium-dependent phosphate transport." [GOC:BHF]
is_a: GO:0010966 ! regulation of phosphate transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044341 ! sodium-dependent phosphate transport
relationship: regulates GO:0044341 ! sodium-dependent phosphate transport
created_by: jane
creation_date: 2010-09-23T01:34:59Z

[Term]
id: GO:2000119
name: negative regulation of sodium-dependent phosphate transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sodium-dependent phosphate transport." [GOC:BHF]
is_a: GO:1903792 ! negative regulation of anion transport
is_a: GO:2000118 ! regulation of sodium-dependent phosphate transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044341 ! sodium-dependent phosphate transport
relationship: negatively_regulates GO:0044341 ! sodium-dependent phosphate transport
created_by: jane
creation_date: 2010-09-23T01:35:03Z

[Term]
id: GO:2000120
name: positive regulation of sodium-dependent phosphate transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sodium-dependent phosphate transport." [GOC:BHF]
is_a: GO:1903793 ! positive regulation of anion transport
is_a: GO:2000118 ! regulation of sodium-dependent phosphate transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044341 ! sodium-dependent phosphate transport
relationship: positively_regulates GO:0044341 ! sodium-dependent phosphate transport
created_by: jane
creation_date: 2010-09-23T01:35:06Z

[Term]
id: GO:2000121
name: regulation of removal of superoxide radicals
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of removal of superoxide radicals." [GOC:obol]
synonym: "regulation of removal of O2-" EXACT [GOC:obol]
synonym: "regulation of removal of oxygen free radicals" EXACT [GOC:obol]
is_a: GO:0090322 ! regulation of superoxide metabolic process
is_a: GO:1900407 ! regulation of cellular response to oxidative stress
is_a: GO:1901031 ! regulation of response to reactive oxygen species
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019430 ! removal of superoxide radicals
relationship: regulates GO:0019430 ! removal of superoxide radicals
created_by: dhl
creation_date: 2010-09-27T05:30:37Z

[Term]
id: GO:2000122
name: negative regulation of stomatal complex development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of stomatal complex development." [GOC:obol]
is_a: GO:0048581 ! negative regulation of post-embryonic development
is_a: GO:2000038 ! regulation of stomatal complex development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010374 ! stomatal complex development
relationship: negatively_regulates GO:0010374 ! stomatal complex development
created_by: dhl
creation_date: 2010-09-27T08:28:26Z

[Term]
id: GO:2000123
name: positive regulation of stomatal complex development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of stomatal complex development." [GOC:obol]
is_a: GO:0048582 ! positive regulation of post-embryonic development
is_a: GO:2000038 ! regulation of stomatal complex development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010374 ! stomatal complex development
relationship: positively_regulates GO:0010374 ! stomatal complex development
created_by: dhl
creation_date: 2010-09-27T08:28:28Z

[Term]
id: GO:2000124
name: regulation of endocannabinoid signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endocannabinoid signaling pathway." [GOC:mah, PMID:15550444]
synonym: "regulation of endocannabinoid signalling pathway" EXACT [GOC:obol]
is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071926 ! endocannabinoid signaling pathway
relationship: regulates GO:0071926 ! endocannabinoid signaling pathway
created_by: midori
creation_date: 2010-09-29T09:05:43Z

[Term]
id: GO:2000125
name: regulation of octopamine or tyramine signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of octopamine or tyramine signaling pathway." [GOC:mah]
synonym: "regulation of octopamine or tyramine signalling pathway" EXACT [GOC:obol]
synonym: "regulation of octopamine/tyramine signaling pathway" EXACT [GOC:obol]
is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007211 ! octopamine or tyramine signaling pathway
relationship: regulates GO:0007211 ! octopamine or tyramine signaling pathway
created_by: midori
creation_date: 2010-09-29T09:27:12Z

[Term]
id: GO:2000126
name: negative regulation of octopamine or tyramine signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of octopamine or tyramine signaling pathway." [GOC:mah]
synonym: "negative regulation of octopamine or tyramine signalling pathway" EXACT [GOC:obol]
synonym: "negative regulation of octopamine/tyramine signaling pathway" EXACT [GOC:obol]
is_a: GO:0045744 ! negative regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:2000125 ! regulation of octopamine or tyramine signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007211 ! octopamine or tyramine signaling pathway
relationship: negatively_regulates GO:0007211 ! octopamine or tyramine signaling pathway
created_by: midori
creation_date: 2010-09-29T09:27:16Z

[Term]
id: GO:2000127
name: positive regulation of octopamine or tyramine signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of octopamine or tyramine signaling pathway." [GOC:mah]
synonym: "positive regulation of octopamine or tyramine signalling pathway" EXACT [GOC:obol]
synonym: "positive regulation of octopamine/tyramine signaling pathway" EXACT [GOC:obol]
is_a: GO:0045745 ! positive regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:2000125 ! regulation of octopamine or tyramine signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007211 ! octopamine or tyramine signaling pathway
relationship: positively_regulates GO:0007211 ! octopamine or tyramine signaling pathway
created_by: midori
creation_date: 2010-09-29T09:27:19Z

[Term]
id: GO:2000128
name: regulation of octopamine signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of octopamine signaling pathway." [GOC:mah]
synonym: "regulation of octopamine signalling pathway" EXACT [GOC:obol]
is_a: GO:2000125 ! regulation of octopamine or tyramine signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071927 ! octopamine signaling pathway
relationship: regulates GO:0071927 ! octopamine signaling pathway
created_by: midori
creation_date: 2010-09-29T09:29:41Z

[Term]
id: GO:2000129
name: negative regulation of octopamine signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of octopamine signaling pathway." [GOC:mah]
synonym: "negative regulation of octopamine signalling pathway" EXACT [GOC:obol]
is_a: GO:2000126 ! negative regulation of octopamine or tyramine signaling pathway
is_a: GO:2000128 ! regulation of octopamine signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071927 ! octopamine signaling pathway
relationship: negatively_regulates GO:0071927 ! octopamine signaling pathway
created_by: midori
creation_date: 2010-09-29T09:29:44Z

[Term]
id: GO:2000130
name: positive regulation of octopamine signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of octopamine signaling pathway." [GOC:mah]
synonym: "positive regulation of octopamine signalling pathway" EXACT [GOC:obol]
is_a: GO:2000127 ! positive regulation of octopamine or tyramine signaling pathway
is_a: GO:2000128 ! regulation of octopamine signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071927 ! octopamine signaling pathway
relationship: positively_regulates GO:0071927 ! octopamine signaling pathway
created_by: midori
creation_date: 2010-09-29T09:29:47Z

[Term]
id: GO:2000131
name: regulation of tyramine signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tyramine signaling pathway." [GOC:mah]
synonym: "regulation of tyramine signalling pathway" EXACT [GOC:obol]
is_a: GO:2000125 ! regulation of octopamine or tyramine signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071928 ! tyramine signaling pathway
relationship: regulates GO:0071928 ! tyramine signaling pathway
created_by: midori
creation_date: 2010-09-29T09:31:56Z

[Term]
id: GO:2000132
name: negative regulation of tyramine signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of tyramine signaling pathway." [GOC:mah]
synonym: "negative regulation of tyramine signalling pathway" EXACT [GOC:obol]
is_a: GO:2000126 ! negative regulation of octopamine or tyramine signaling pathway
is_a: GO:2000131 ! regulation of tyramine signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071928 ! tyramine signaling pathway
relationship: negatively_regulates GO:0071928 ! tyramine signaling pathway
created_by: midori
creation_date: 2010-09-29T09:32:00Z

[Term]
id: GO:2000133
name: positive regulation of tyramine signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tyramine signaling pathway." [GOC:mah]
synonym: "positive regulation of tyramine signalling pathway" EXACT [GOC:obol]
is_a: GO:2000127 ! positive regulation of octopamine or tyramine signaling pathway
is_a: GO:2000131 ! regulation of tyramine signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071928 ! tyramine signaling pathway
relationship: positively_regulates GO:0071928 ! tyramine signaling pathway
created_by: midori
creation_date: 2010-09-29T09:32:03Z

[Term]
id: GO:2000134
name: negative regulation of G1/S transition of mitotic cell cycle
namespace: biological_process
def: "Any cell cycle regulatory process that prevents the commitment of a cell from G1 to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle]
is_a: GO:1901991 ! negative regulation of mitotic cell cycle phase transition
is_a: GO:1902807 ! negative regulation of cell cycle G1/S phase transition
is_a: GO:2000045 ! regulation of G1/S transition of mitotic cell cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000082 ! G1/S transition of mitotic cell cycle
relationship: negatively_regulates GO:0000082 ! G1/S transition of mitotic cell cycle
created_by: midori
creation_date: 2010-09-29T09:38:51Z

[Term]
id: GO:2000135
name: obsolete positive regulation of regulation of secondary heart field cardioblast proliferation
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of regulation of secondary heart field cardioblast proliferation." [GOC:dph]
comment: This term was made obsolete because it makes no sense and was added in error.
synonym: "positive regulation of regulation of second heart field cardioblast proliferation" EXACT [GOC:obol]
synonym: "positive regulation of regulation of secondary heart field cardioblast proliferation" EXACT []
is_obsolete: true
created_by: dph
creation_date: 2010-09-29T12:40:37Z

[Term]
id: GO:2000136
name: regulation of cell proliferation involved in heart morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell proliferation involved in heart morphogenesis." [GOC:dph]
is_a: GO:0042127 ! regulation of cell proliferation
is_a: GO:2000826 ! regulation of heart morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061323 ! cell proliferation involved in heart morphogenesis
relationship: regulates GO:0061323 ! cell proliferation involved in heart morphogenesis
created_by: dph
creation_date: 2010-09-29T12:43:53Z

[Term]
id: GO:2000137
name: negative regulation of cell proliferation involved in heart morphogenesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell proliferation involved in heart morphogenesis." [GOC:dph]
is_a: GO:0008285 ! negative regulation of cell proliferation
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000136 ! regulation of cell proliferation involved in heart morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061323 ! cell proliferation involved in heart morphogenesis
relationship: negatively_regulates GO:0061323 ! cell proliferation involved in heart morphogenesis
created_by: dph
creation_date: 2010-09-29T12:43:55Z

[Term]
id: GO:2000138
name: positive regulation of cell proliferation involved in heart morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in heart morphogenesis." [GOC:dph]
is_a: GO:0008284 ! positive regulation of cell proliferation
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000136 ! regulation of cell proliferation involved in heart morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061323 ! cell proliferation involved in heart morphogenesis
relationship: positively_regulates GO:0061323 ! cell proliferation involved in heart morphogenesis
created_by: dph
creation_date: 2010-09-29T12:43:57Z

[Term]
id: GO:2000139
name: regulation of octopamine signaling pathway involved in response to food
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of octopamine signaling pathway involved in response to food." [GOC:mah, PMID:19609300]
synonym: "regulation of octopamine signalling pathway involved in response to food" EXACT [GOC:mah]
is_a: GO:0032095 ! regulation of response to food
is_a: GO:2000128 ! regulation of octopamine signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071935 ! octopamine signaling pathway involved in response to food
relationship: regulates GO:0071935 ! octopamine signaling pathway involved in response to food
created_by: midori
creation_date: 2010-09-30T02:48:07Z

[Term]
id: GO:2000140
name: negative regulation of octopamine signaling pathway involved in response to food
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of octopamine signaling pathway involved in response to food." [GOC:mah, PMID:19609300]
synonym: "negative regulation of octopamine signalling pathway involved in response to food" EXACT [GOC:mah]
is_a: GO:0032096 ! negative regulation of response to food
is_a: GO:2000129 ! negative regulation of octopamine signaling pathway
is_a: GO:2000139 ! regulation of octopamine signaling pathway involved in response to food
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071935 ! octopamine signaling pathway involved in response to food
relationship: negatively_regulates GO:0071935 ! octopamine signaling pathway involved in response to food
created_by: midori
creation_date: 2010-09-30T02:48:10Z

[Term]
id: GO:2000141
name: positive regulation of octopamine signaling pathway involved in response to food
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of octopamine signaling pathway involved in response to food." [GOC:mah, PMID:19609300]
synonym: "positive regulation of octopamine signalling pathway involved in response to food" EXACT [GOC:mah]
is_a: GO:0032097 ! positive regulation of response to food
is_a: GO:2000130 ! positive regulation of octopamine signaling pathway
is_a: GO:2000139 ! regulation of octopamine signaling pathway involved in response to food
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071935 ! octopamine signaling pathway involved in response to food
relationship: positively_regulates GO:0071935 ! octopamine signaling pathway involved in response to food
created_by: midori
creation_date: 2010-09-30T02:48:12Z

[Term]
id: GO:2000142
name: regulation of DNA-templated transcription, initiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA-templated transcription initiation." [GOC:mah, GOC:txnOH]
synonym: "regulation of DNA-dependent RNA polymerase complex assembly at promoter" EXACT [GOC:obol]
synonym: "regulation of DNA-dependent transcription, initiation" EXACT [GOC:txnOH]
synonym: "regulation of initiation of DNA-dependent transcription" EXACT [GOC:jh2]
synonym: "regulation of transcription initiation, DNA-dependent" EXACT [GOC:jh2]
is_a: GO:0006355 ! regulation of transcription, DNA-templated
is_a: GO:0043254 ! regulation of protein complex assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006352 ! DNA-templated transcription, initiation
relationship: regulates GO:0006352 ! DNA-templated transcription, initiation
created_by: midori
creation_date: 2010-10-01T09:11:35Z

[Term]
id: GO:2000143
name: negative regulation of DNA-templated transcription, initiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-templated transcription initiation." [GOC:mah, GOC:txnOH]
synonym: "negative regulation of DNA-dependent RNA polymerase complex assembly at promoter" EXACT [GOC:obol]
synonym: "negative regulation of DNA-dependent transcription, initiation" EXACT [GOC:txnOH]
synonym: "negative regulation of initiation of DNA-dependent transcription" EXACT [GOC:jh2]
synonym: "negative regulation of transcription initiation, DNA-dependent" EXACT [GOC:jh2]
is_a: GO:0031333 ! negative regulation of protein complex assembly
is_a: GO:0045892 ! negative regulation of transcription, DNA-templated
is_a: GO:2000142 ! regulation of DNA-templated transcription, initiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006352 ! DNA-templated transcription, initiation
relationship: negatively_regulates GO:0006352 ! DNA-templated transcription, initiation
created_by: midori
creation_date: 2010-10-01T09:11:40Z

[Term]
id: GO:2000144
name: positive regulation of DNA-templated transcription, initiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA-templated transcription initiation." [GOC:mah, GOC:txnOH]
synonym: "positive regulation of DNA-dependent RNA polymerase complex assembly at promoter" EXACT [GOC:obol]
synonym: "positive regulation of DNA-dependent transcription, initiation" EXACT [GOC:txnOH]
synonym: "positive regulation of initiation of DNA-dependent transcription" EXACT [GOC:jh2]
synonym: "positive regulation of transcription initiation, DNA-dependent" EXACT [GOC:jh2]
synonym: "transactivation" RELATED [PMID:11158542]
synonym: "transcriptional transactivation" RELATED [PMID:11580863]
is_a: GO:0031334 ! positive regulation of protein complex assembly
is_a: GO:0045893 ! positive regulation of transcription, DNA-templated
is_a: GO:2000142 ! regulation of DNA-templated transcription, initiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006352 ! DNA-templated transcription, initiation
relationship: positively_regulates GO:0006352 ! DNA-templated transcription, initiation
created_by: midori
creation_date: 2010-10-01T09:11:43Z

[Term]
id: GO:2000145
name: regulation of cell motility
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell motility." [GOC:mah]
synonym: "regulation of cell locomotion" EXACT [GOC:obol]
synonym: "regulation of cell movement" RELATED [GOC:obol]
synonym: "regulation of movement of a cell" EXACT [GOC:obol]
is_a: GO:0040012 ! regulation of locomotion
is_a: GO:0051270 ! regulation of cellular component movement
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048870 ! cell motility
relationship: regulates GO:0048870 ! cell motility
created_by: midori
creation_date: 2010-10-01T09:41:21Z

[Term]
id: GO:2000146
name: negative regulation of cell motility
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility." [GOC:mah]
synonym: "negative regulation of cell locomotion" EXACT [GOC:obol]
synonym: "negative regulation of cell movement" RELATED [GOC:obol]
synonym: "negative regulation of movement of a cell" EXACT [GOC:obol]
is_a: GO:0040013 ! negative regulation of locomotion
is_a: GO:0051271 ! negative regulation of cellular component movement
is_a: GO:2000145 ! regulation of cell motility
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048870 ! cell motility
relationship: negatively_regulates GO:0048870 ! cell motility
created_by: midori
creation_date: 2010-10-01T09:41:26Z

[Term]
id: GO:2000147
name: positive regulation of cell motility
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell motility." [GOC:mah]
synonym: "positive regulation of cell locomotion" EXACT [GOC:obol]
synonym: "positive regulation of cell movement" RELATED [GOC:obol]
synonym: "positive regulation of movement of a cell" EXACT [GOC:obol]
is_a: GO:0040017 ! positive regulation of locomotion
is_a: GO:0051272 ! positive regulation of cellular component movement
is_a: GO:2000145 ! regulation of cell motility
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048870 ! cell motility
relationship: positively_regulates GO:0048870 ! cell motility
created_by: midori
creation_date: 2010-10-01T09:41:30Z

[Term]
id: GO:2000148
name: regulation of planar cell polarity pathway involved in ventricular septum morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in ventricular septum morphogenesis." [GOC:dph]
is_a: GO:1901219 ! regulation of cardiac chamber morphogenesis
is_a: GO:1904412 ! regulation of cardiac ventricle development
is_a: GO:2000159 ! regulation of planar cell polarity pathway involved in heart morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061348 ! planar cell polarity pathway involved in ventricular septum morphogenesis
relationship: regulates GO:0061348 ! planar cell polarity pathway involved in ventricular septum morphogenesis
created_by: dph
creation_date: 2010-10-01T07:09:49Z

[Term]
id: GO:2000149
name: negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in ventricular septum morphogenesis." [GOC:dph]
is_a: GO:1901220 ! negative regulation of cardiac chamber morphogenesis
is_a: GO:1904413 ! negative regulation of cardiac ventricle development
is_a: GO:2000148 ! regulation of planar cell polarity pathway involved in ventricular septum morphogenesis
is_a: GO:2000160 ! negative regulation of planar cell polarity pathway involved in heart morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061348 ! planar cell polarity pathway involved in ventricular septum morphogenesis
relationship: negatively_regulates GO:0061348 ! planar cell polarity pathway involved in ventricular septum morphogenesis
created_by: dph
creation_date: 2010-10-01T07:09:53Z

[Term]
id: GO:2000150
name: regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis." [GOC:dph]
is_a: GO:0055024 ! regulation of cardiac muscle tissue development
is_a: GO:2000159 ! regulation of planar cell polarity pathway involved in heart morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061350 ! planar cell polarity pathway involved in cardiac muscle tissue morphogenesis
relationship: regulates GO:0061350 ! planar cell polarity pathway involved in cardiac muscle tissue morphogenesis
created_by: dph
creation_date: 2010-10-01T07:11:11Z

[Term]
id: GO:2000151
name: negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis." [GOC:dph]
is_a: GO:0055026 ! negative regulation of cardiac muscle tissue development
is_a: GO:2000150 ! regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis
is_a: GO:2000160 ! negative regulation of planar cell polarity pathway involved in heart morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061350 ! planar cell polarity pathway involved in cardiac muscle tissue morphogenesis
relationship: negatively_regulates GO:0061350 ! planar cell polarity pathway involved in cardiac muscle tissue morphogenesis
created_by: dph
creation_date: 2010-10-01T07:11:15Z

[Term]
id: GO:2000152
name: regulation of ubiquitin-specific protease activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of regulation of ubiquitin-specific protease activity (deubiquitinase) activity." [GOC:obol]
synonym: "regulation of deubiquitinase activity" EXACT []
synonym: "regulation of UBP" RELATED [GOC:obol]
synonym: "regulation of UCH2" RELATED [GOC:obol]
is_a: GO:0052547 ! regulation of peptidase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004843 ! thiol-dependent ubiquitin-specific protease activity
relationship: regulates GO:0004843 ! thiol-dependent ubiquitin-specific protease activity
created_by: tanyaberardini
creation_date: 2010-10-01T10:09:28Z

[Term]
id: GO:2000153
name: obsolete regulation of flagellar cell motility
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of flagellar cell motility." [GOC:mah]
comment: This term was made obsolete because microtubule-based flagellum (GO:0009434) and motile cilium (GO:0031514), as referenced by this term, were determined to be equivalent and merged. When a merge for this term was considered, it was noticed that both eukaryotic and prokaryotic proteins are annotated to it because its meaning had been ambiguous so obsoletion was considered safest.
synonym: "regulation of flagellar cell motility" EXACT []
is_obsolete: true
consider: GO:1902019
consider: GO:1902021
created_by: midori
creation_date: 2010-10-04T12:41:02Z

[Term]
id: GO:2000154
name: obsolete negative regulation of flagellar cell motility
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of flagellar cell motility." [GOC:mah]
comment: This term was made obsolete because microtubule-based flagellum (GO:0009434) and motile cilium (GO:0031514), as referenced by this term, were determined to be equivalent and merged. When a merge for this term was considered, it was noticed that both eukaryotic and prokaryotic proteins are annotated to it because its meaning had been ambiguous so obsoletion was considered safest.
synonym: "negative regulation of flagellar cell motility" EXACT []
is_obsolete: true
consider: GO:1902020
consider: GO:1902201
created_by: midori
creation_date: 2010-10-04T12:41:04Z

[Term]
id: GO:2000155
name: positive regulation of cilium-dependent cell motility
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cilium-dependent cell motility." [GOC:cilia, GOC:jl]
synonym: "positive regulation of ciliary cell motility" RELATED []
is_a: GO:0003353 ! positive regulation of cilium movement
is_a: GO:1902019 ! regulation of cilium-dependent cell motility
is_a: GO:2000147 ! positive regulation of cell motility
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060285 ! cilium-dependent cell motility
relationship: positively_regulates GO:0060285 ! cilium-dependent cell motility
created_by: midori
creation_date: 2010-10-04T12:41:05Z

[Term]
id: GO:2000156
name: regulation of retrograde vesicle-mediated transport, Golgi to ER
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of retrograde vesicle-mediated transport, Golgi to ER." [GOC:mah]
synonym: "regulation of cis-Golgi to rough endoplasmic reticulum transport" EXACT [GOC:obol]
synonym: "regulation of cis-Golgi to rough endoplasmic reticulum vesicle-mediated transport" EXACT [GOC:obol]
synonym: "regulation of cis-Golgi to rough ER transport" EXACT [GOC:obol]
synonym: "regulation of cis-Golgi to rough ER vesicle-mediated transport" EXACT [GOC:obol]
synonym: "regulation of retrograde (Golgi to ER) transport" EXACT [GOC:obol]
synonym: "regulation of retrograde transport, Golgi to endoplasmic reticulum" EXACT [GOC:obol]
synonym: "regulation of retrograde transport, Golgi to ER" EXACT [GOC:obol]
synonym: "regulation of retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum" RELATED [GOC:obol]
is_a: GO:0032386 ! regulation of intracellular transport
is_a: GO:0060627 ! regulation of vesicle-mediated transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006890 ! retrograde vesicle-mediated transport, Golgi to ER
relationship: regulates GO:0006890 ! retrograde vesicle-mediated transport, Golgi to ER
created_by: midori
creation_date: 2010-10-04T12:46:35Z

[Term]
id: GO:2000157
name: negative regulation of ubiquitin-specific protease activity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin-specific protease (deubiquitinase) activity." [GOC:obol]
synonym: "negative regulation of deubiquitinase activity" EXACT []
synonym: "negative regulation of ubiquitin hydrolase activity" EXACT [GOC:obol]
synonym: "negative regulation of UBP" RELATED [GOC:obol]
synonym: "negative regulation of UCH2" RELATED [GOC:obol]
is_a: GO:0010466 ! negative regulation of peptidase activity
is_a: GO:2000152 ! regulation of ubiquitin-specific protease activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004843 ! thiol-dependent ubiquitin-specific protease activity
relationship: negatively_regulates GO:0004843 ! thiol-dependent ubiquitin-specific protease activity
created_by: tanyaberardini
creation_date: 2010-10-04T10:42:27Z

[Term]
id: GO:2000158
name: positive regulation of ubiquitin-specific protease activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ubiquitin-specific protease (deubiquitinase) activity." [GOC:obol]
synonym: "positive regulation of deubiquitinase activity" EXACT []
synonym: "positive regulation of ubiquitin hydrolase activity" EXACT [GOC:obol]
synonym: "positive regulation of UBP" RELATED [GOC:obol]
synonym: "positive regulation of UCH2" RELATED [GOC:obol]
is_a: GO:0010952 ! positive regulation of peptidase activity
is_a: GO:2000152 ! regulation of ubiquitin-specific protease activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004843 ! thiol-dependent ubiquitin-specific protease activity
relationship: positively_regulates GO:0004843 ! thiol-dependent ubiquitin-specific protease activity
created_by: tanyaberardini
creation_date: 2010-10-04T10:42:29Z

[Term]
id: GO:2000159
name: regulation of planar cell polarity pathway involved in heart morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in heart morphogenesis." [GOC:dph]
is_a: GO:0003307 ! regulation of Wnt signaling pathway involved in heart development
is_a: GO:2000095 ! regulation of Wnt signaling pathway, planar cell polarity pathway
is_a: GO:2000826 ! regulation of heart morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061346 ! planar cell polarity pathway involved in heart morphogenesis
relationship: regulates GO:0061346 ! planar cell polarity pathway involved in heart morphogenesis
created_by: dph
creation_date: 2010-10-05T01:03:22Z

[Term]
id: GO:2000160
name: negative regulation of planar cell polarity pathway involved in heart morphogenesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in heart morphogenesis." [GOC:dph]
is_a: GO:0003308 ! negative regulation of Wnt signaling pathway involved in heart development
is_a: GO:2000051 ! negative regulation of non-canonical Wnt signaling pathway
is_a: GO:2000159 ! regulation of planar cell polarity pathway involved in heart morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061346 ! planar cell polarity pathway involved in heart morphogenesis
relationship: negatively_regulates GO:0061346 ! planar cell polarity pathway involved in heart morphogenesis
created_by: dph
creation_date: 2010-10-05T01:03:25Z

[Term]
id: GO:2000161
name: regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in cardiac right atrium morphogenesis." [GOC:dph]
is_a: GO:1901219 ! regulation of cardiac chamber morphogenesis
is_a: GO:2000159 ! regulation of planar cell polarity pathway involved in heart morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061349 ! planar cell polarity pathway involved in cardiac right atrium morphogenesis
relationship: regulates GO:0061349 ! planar cell polarity pathway involved in cardiac right atrium morphogenesis
created_by: dph
creation_date: 2010-10-05T01:05:21Z

[Term]
id: GO:2000162
name: negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in cardiac right atrium morphogenesis." [GOC:dph]
is_a: GO:1901220 ! negative regulation of cardiac chamber morphogenesis
is_a: GO:2000160 ! negative regulation of planar cell polarity pathway involved in heart morphogenesis
is_a: GO:2000161 ! regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061349 ! planar cell polarity pathway involved in cardiac right atrium morphogenesis
relationship: negatively_regulates GO:0061349 ! planar cell polarity pathway involved in cardiac right atrium morphogenesis
created_by: dph
creation_date: 2010-10-05T01:05:24Z

[Term]
id: GO:2000163
name: regulation of planar cell polarity pathway involved in outflow tract morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in outflow tract morphogenesis." [GOC:dph]
is_a: GO:2000159 ! regulation of planar cell polarity pathway involved in heart morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061347 ! planar cell polarity pathway involved in outflow tract morphogenesis
relationship: regulates GO:0061347 ! planar cell polarity pathway involved in outflow tract morphogenesis
created_by: dph
creation_date: 2010-10-05T01:06:13Z

[Term]
id: GO:2000164
name: negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in outflow tract morphogenesis." [GOC:dph]
is_a: GO:2000160 ! negative regulation of planar cell polarity pathway involved in heart morphogenesis
is_a: GO:2000163 ! regulation of planar cell polarity pathway involved in outflow tract morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061347 ! planar cell polarity pathway involved in outflow tract morphogenesis
relationship: negatively_regulates GO:0061347 ! planar cell polarity pathway involved in outflow tract morphogenesis
created_by: dph
creation_date: 2010-10-05T01:06:15Z

[Term]
id: GO:2000165
name: regulation of planar cell polarity pathway involved in pericardium morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in pericardium morphogenesis." [GOC:dph]
is_a: GO:0045995 ! regulation of embryonic development
is_a: GO:2000159 ! regulation of planar cell polarity pathway involved in heart morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061354 ! planar cell polarity pathway involved in pericardium morphogenesis
relationship: regulates GO:0061354 ! planar cell polarity pathway involved in pericardium morphogenesis
created_by: dph
creation_date: 2010-10-05T01:07:36Z

[Term]
id: GO:2000166
name: negative regulation of planar cell polarity pathway involved in pericardium morphogenesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in pericardium morphogenesis." [GOC:dph]
is_a: GO:0045992 ! negative regulation of embryonic development
is_a: GO:2000160 ! negative regulation of planar cell polarity pathway involved in heart morphogenesis
is_a: GO:2000165 ! regulation of planar cell polarity pathway involved in pericardium morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061354 ! planar cell polarity pathway involved in pericardium morphogenesis
relationship: negatively_regulates GO:0061354 ! planar cell polarity pathway involved in pericardium morphogenesis
created_by: dph
creation_date: 2010-10-05T01:07:39Z

[Term]
id: GO:2000167
name: regulation of planar cell polarity pathway involved in neural tube closure
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in neural tube closure." [GOC:dph]
is_a: GO:0090178 ! regulation of establishment of planar polarity involved in neural tube closure
is_a: GO:2000095 ! regulation of Wnt signaling pathway, planar cell polarity pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0090179 ! planar cell polarity pathway involved in neural tube closure
relationship: regulates GO:0090179 ! planar cell polarity pathway involved in neural tube closure
created_by: dph
creation_date: 2010-10-05T01:08:53Z

[Term]
id: GO:2000168
name: negative regulation of planar cell polarity pathway involved in neural tube closure
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in neural tube closure." [GOC:dph]
is_a: GO:0045992 ! negative regulation of embryonic development
is_a: GO:0051961 ! negative regulation of nervous system development
is_a: GO:2000051 ! negative regulation of non-canonical Wnt signaling pathway
is_a: GO:2000167 ! regulation of planar cell polarity pathway involved in neural tube closure
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0090179 ! planar cell polarity pathway involved in neural tube closure
relationship: negatively_regulates GO:0090179 ! planar cell polarity pathway involved in neural tube closure
created_by: dph
creation_date: 2010-10-05T01:08:56Z

[Term]
id: GO:2000169
name: regulation of peptidyl-cysteine S-nitrosylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of peptidyl-cysteine S-nitrosylation." [GOC:obol]
is_a: GO:0031399 ! regulation of protein modification process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0018119 ! peptidyl-cysteine S-nitrosylation
relationship: regulates GO:0018119 ! peptidyl-cysteine S-nitrosylation
created_by: rl
creation_date: 2010-10-07T10:49:32Z

[Term]
id: GO:2000170
name: positive regulation of peptidyl-cysteine S-nitrosylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of peptidyl-cysteine S-nitrosylation." [GOC:obol]
is_a: GO:0031401 ! positive regulation of protein modification process
is_a: GO:2000169 ! regulation of peptidyl-cysteine S-nitrosylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0018119 ! peptidyl-cysteine S-nitrosylation
relationship: positively_regulates GO:0018119 ! peptidyl-cysteine S-nitrosylation
created_by: rl
creation_date: 2010-10-07T10:49:35Z

[Term]
id: GO:2000171
name: negative regulation of dendrite development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite development." [GOC:obol]
is_a: GO:0010977 ! negative regulation of neuron projection development
is_a: GO:0050773 ! regulation of dendrite development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016358 ! dendrite development
relationship: negatively_regulates GO:0016358 ! dendrite development
created_by: rl
creation_date: 2010-10-07T10:53:15Z

[Term]
id: GO:2000172
name: regulation of branching morphogenesis of a nerve
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of branching morphogenesis of a nerve." [GOC:BHF]
is_a: GO:0051960 ! regulation of nervous system development
is_a: GO:0060688 ! regulation of morphogenesis of a branching structure
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048755 ! branching morphogenesis of a nerve
relationship: regulates GO:0048755 ! branching morphogenesis of a nerve
created_by: rl
creation_date: 2010-10-07T12:07:54Z

[Term]
id: GO:2000173
name: negative regulation of branching morphogenesis of a nerve
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of branching morphogenesis of a nerve." [GOC:BHF]
is_a: GO:0051961 ! negative regulation of nervous system development
is_a: GO:2000172 ! regulation of branching morphogenesis of a nerve
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048755 ! branching morphogenesis of a nerve
relationship: negatively_regulates GO:0048755 ! branching morphogenesis of a nerve
created_by: rl
creation_date: 2010-10-07T12:07:56Z

[Term]
id: GO:2000174
name: regulation of pro-T cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pro-T cell differentiation." [GOC:BHF]
synonym: "regulation of pro-T lymphocyte differentiation" EXACT [GOC:obol]
is_a: GO:0045580 ! regulation of T cell differentiation
is_a: GO:1901532 ! regulation of hematopoietic progenitor cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002572 ! pro-T cell differentiation
relationship: regulates GO:0002572 ! pro-T cell differentiation
created_by: midori
creation_date: 2010-10-11T10:24:30Z

[Term]
id: GO:2000175
name: negative regulation of pro-T cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pro-T cell differentiation." [GOC:BHF]
synonym: "negative regulation of pro-T lymphocyte differentiation" EXACT [GOC:obol]
is_a: GO:0045581 ! negative regulation of T cell differentiation
is_a: GO:1901533 ! negative regulation of hematopoietic progenitor cell differentiation
is_a: GO:2000174 ! regulation of pro-T cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002572 ! pro-T cell differentiation
relationship: negatively_regulates GO:0002572 ! pro-T cell differentiation
created_by: midori
creation_date: 2010-10-11T10:24:33Z

[Term]
id: GO:2000176
name: positive regulation of pro-T cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pro-T cell differentiation." [GOC:BHF]
synonym: "positive regulation of pro-T lymphocyte differentiation" EXACT [GOC:obol]
is_a: GO:0045582 ! positive regulation of T cell differentiation
is_a: GO:1901534 ! positive regulation of hematopoietic progenitor cell differentiation
is_a: GO:2000174 ! regulation of pro-T cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002572 ! pro-T cell differentiation
relationship: positively_regulates GO:0002572 ! pro-T cell differentiation
created_by: midori
creation_date: 2010-10-11T10:24:35Z

[Term]
id: GO:2000177
name: regulation of neural precursor cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neural precursor cell proliferation." [GOC:dph, GOC:yaf]
is_a: GO:0042127 ! regulation of cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061351 ! neural precursor cell proliferation
relationship: regulates GO:0061351 ! neural precursor cell proliferation
created_by: dph
creation_date: 2010-10-13T12:40:41Z

[Term]
id: GO:2000178
name: negative regulation of neural precursor cell proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neural precursor cell proliferation." [GOC:dph, GOC:yaf]
is_a: GO:0008285 ! negative regulation of cell proliferation
is_a: GO:2000177 ! regulation of neural precursor cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061351 ! neural precursor cell proliferation
relationship: negatively_regulates GO:0061351 ! neural precursor cell proliferation
created_by: dph
creation_date: 2010-10-13T12:40:43Z

[Term]
id: GO:2000179
name: positive regulation of neural precursor cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation." [GOC:dph, GOC:yaf]
is_a: GO:0008284 ! positive regulation of cell proliferation
is_a: GO:2000177 ! regulation of neural precursor cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061351 ! neural precursor cell proliferation
relationship: positively_regulates GO:0061351 ! neural precursor cell proliferation
created_by: dph
creation_date: 2010-10-13T12:40:45Z

[Term]
id: GO:2000180
name: negative regulation of androgen biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of androgen biosynthetic process." [GOC:dph, GOC:yaf]
synonym: "negative regulation of androgen anabolism" EXACT [GOC:obol]
synonym: "negative regulation of androgen biosynthesis" EXACT [GOC:obol]
synonym: "negative regulation of androgen formation" EXACT [GOC:obol]
synonym: "negative regulation of androgen synthesis" EXACT [GOC:obol]
is_a: GO:0010894 ! negative regulation of steroid biosynthetic process
is_a: GO:0032353 ! negative regulation of hormone biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006702 ! androgen biosynthetic process
relationship: negatively_regulates GO:0006702 ! androgen biosynthetic process
created_by: dph
creation_date: 2010-10-13T12:43:17Z

[Term]
id: GO:2000181
name: negative regulation of blood vessel morphogenesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel morphogenesis." [GOC:dph, GOC:yaf]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:1901343 ! negative regulation of vasculature development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048514 ! blood vessel morphogenesis
relationship: negatively_regulates GO:0048514 ! blood vessel morphogenesis
created_by: dph
creation_date: 2010-10-13T12:46:31Z

[Term]
id: GO:2000182
name: regulation of progesterone biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of progesterone biosynthetic process." [GOC:dph]
synonym: "regulation of progesterone anabolism" EXACT [GOC:obol]
synonym: "regulation of progesterone biosynthesis" EXACT [GOC:obol]
synonym: "regulation of progesterone formation" EXACT [GOC:obol]
synonym: "regulation of progesterone synthesis" EXACT [GOC:obol]
is_a: GO:0010566 ! regulation of ketone biosynthetic process
is_a: GO:0046885 ! regulation of hormone biosynthetic process
is_a: GO:0050810 ! regulation of steroid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006701 ! progesterone biosynthetic process
relationship: regulates GO:0006701 ! progesterone biosynthetic process
created_by: dph
creation_date: 2010-10-14T07:36:06Z

[Term]
id: GO:2000183
name: negative regulation of progesterone biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of progesterone biosynthetic process." [GOC:dph]
synonym: "negative regulation of progesterone anabolism" EXACT [GOC:obol]
synonym: "negative regulation of progesterone biosynthesis" EXACT [GOC:obol]
synonym: "negative regulation of progesterone formation" EXACT [GOC:obol]
synonym: "negative regulation of progesterone synthesis" EXACT [GOC:obol]
is_a: GO:0010894 ! negative regulation of steroid biosynthetic process
is_a: GO:0032353 ! negative regulation of hormone biosynthetic process
is_a: GO:2000182 ! regulation of progesterone biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006701 ! progesterone biosynthetic process
relationship: negatively_regulates GO:0006701 ! progesterone biosynthetic process
created_by: dph
creation_date: 2010-10-14T07:36:10Z

[Term]
id: GO:2000184
name: positive regulation of progesterone biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of progesterone biosynthetic process." [GOC:dph]
synonym: "positive regulation of progesterone anabolism" EXACT [GOC:obol]
synonym: "positive regulation of progesterone biosynthesis" EXACT [GOC:obol]
synonym: "positive regulation of progesterone formation" EXACT [GOC:obol]
synonym: "positive regulation of progesterone synthesis" EXACT [GOC:obol]
is_a: GO:0010893 ! positive regulation of steroid biosynthetic process
is_a: GO:0046886 ! positive regulation of hormone biosynthetic process
is_a: GO:2000182 ! regulation of progesterone biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006701 ! progesterone biosynthetic process
relationship: positively_regulates GO:0006701 ! progesterone biosynthetic process
created_by: dph
creation_date: 2010-10-14T07:36:14Z

[Term]
id: GO:2000185
name: regulation of phosphate transmembrane transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phosphate transmembrane transport." [GOC:obol]
synonym: "regulation of phosphate membrane transport" EXACT []
is_a: GO:0010966 ! regulation of phosphate transport
is_a: GO:1903795 ! regulation of inorganic anion transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035435 ! phosphate ion transmembrane transport
relationship: regulates GO:0035435 ! phosphate ion transmembrane transport
created_by: vw
creation_date: 2010-10-15T11:33:04Z

[Term]
id: GO:2000186
name: negative regulation of phosphate transmembrane transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of phosphate transmembrane transport." [GOC:obol]
synonym: "negative regulation of phosphate membrane transport" EXACT []
is_a: GO:1903796 ! negative regulation of inorganic anion transmembrane transport
is_a: GO:2000185 ! regulation of phosphate transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035435 ! phosphate ion transmembrane transport
relationship: negatively_regulates GO:0035435 ! phosphate ion transmembrane transport
created_by: vw
creation_date: 2010-10-15T11:33:08Z

[Term]
id: GO:2000187
name: positive regulation of phosphate transmembrane transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phosphate transmembrane transport." [GOC:obol]
synonym: "positive regulation of phosphate membrane transport" EXACT []
is_a: GO:1903797 ! positive regulation of inorganic anion transmembrane transport
is_a: GO:2000185 ! regulation of phosphate transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035435 ! phosphate ion transmembrane transport
relationship: positively_regulates GO:0035435 ! phosphate ion transmembrane transport
created_by: vw
creation_date: 2010-10-15T11:33:10Z

[Term]
id: GO:2000188
name: regulation of cholesterol homeostasis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cholesterol homeostasis." [GOC:BHF]
is_a: GO:0032844 ! regulation of homeostatic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042632 ! cholesterol homeostasis
relationship: regulates GO:0042632 ! cholesterol homeostasis
created_by: rl
creation_date: 2010-10-15T02:20:23Z

[Term]
id: GO:2000189
name: positive regulation of cholesterol homeostasis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cholesterol homeostasis." [GOC:BHF]
is_a: GO:0032846 ! positive regulation of homeostatic process
is_a: GO:2000188 ! regulation of cholesterol homeostasis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042632 ! cholesterol homeostasis
relationship: positively_regulates GO:0042632 ! cholesterol homeostasis
created_by: rl
creation_date: 2010-10-15T02:20:27Z

[Term]
id: GO:2000190
name: obsolete negative regulation of regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor." [GOC:BHF]
comment: This term was made obsolete because it makes no sense and was added in error.
synonym: "negative regulation of regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor" EXACT []
is_obsolete: true
consider: GO:0000122
consider: GO:0004879
consider: GO:0030522
consider: GO:0038049
created_by: rl
creation_date: 2010-10-18T10:02:57Z

[Term]
id: GO:2000191
name: regulation of fatty acid transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fatty acid transport." [GOC:BHF]
is_a: GO:0032368 ! regulation of lipid transport
is_a: GO:0032890 ! regulation of organic acid transport
is_a: GO:0044070 ! regulation of anion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0015908 ! fatty acid transport
relationship: regulates GO:0015908 ! fatty acid transport
created_by: rl
creation_date: 2010-10-18T10:37:13Z

[Term]
id: GO:2000192
name: negative regulation of fatty acid transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid transport." [GOC:BHF]
is_a: GO:0032369 ! negative regulation of lipid transport
is_a: GO:0032891 ! negative regulation of organic acid transport
is_a: GO:1903792 ! negative regulation of anion transport
is_a: GO:2000191 ! regulation of fatty acid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0015908 ! fatty acid transport
relationship: negatively_regulates GO:0015908 ! fatty acid transport
created_by: rl
creation_date: 2010-10-18T10:37:15Z

[Term]
id: GO:2000193
name: positive regulation of fatty acid transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of fatty acid transport." [GOC:BHF]
is_a: GO:0032370 ! positive regulation of lipid transport
is_a: GO:0032892 ! positive regulation of organic acid transport
is_a: GO:1903793 ! positive regulation of anion transport
is_a: GO:2000191 ! regulation of fatty acid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0015908 ! fatty acid transport
relationship: positively_regulates GO:0015908 ! fatty acid transport
created_by: rl
creation_date: 2010-10-18T10:37:17Z

[Term]
id: GO:2000194
name: regulation of female gonad development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of female gonad development." [GOC:obol]
synonym: "regulation of ovarian development" EXACT [GOC:obol]
synonym: "regulation of ovary development" EXACT [GOC:obol]
is_a: GO:2000026 ! regulation of multicellular organismal development
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008585 ! female gonad development
relationship: regulates GO:0008585 ! female gonad development
created_by: yaf
creation_date: 2010-10-19T10:45:34Z

[Term]
id: GO:2000195
name: negative regulation of female gonad development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of female gonad development." [GOC:obol]
synonym: "negative regulation of ovarian development" EXACT [GOC:obol]
synonym: "negative regulation of ovary development" EXACT [GOC:obol]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000194 ! regulation of female gonad development
is_a: GO:2000242 ! negative regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008585 ! female gonad development
relationship: negatively_regulates GO:0008585 ! female gonad development
created_by: yaf
creation_date: 2010-10-19T10:45:38Z

[Term]
id: GO:2000196
name: positive regulation of female gonad development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of female gonad development." [GOC:obol]
synonym: "positive regulation of ovarian development" EXACT [GOC:obol]
synonym: "positive regulation of ovary development" EXACT [GOC:obol]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000194 ! regulation of female gonad development
is_a: GO:2000243 ! positive regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008585 ! female gonad development
relationship: positively_regulates GO:0008585 ! female gonad development
created_by: yaf
creation_date: 2010-10-19T10:45:41Z

[Term]
id: GO:2000197
name: regulation of ribonucleoprotein complex localization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ribonucleoprotein complex localization." [GOC:mah]
synonym: "regulation of cellular ribonucleoprotein complex localization" EXACT [GOC:obol]
synonym: "regulation of establishment and maintenance of ribonucleoprotein complex localization" EXACT [GOC:obol]
synonym: "regulation of ribonucleoprotein complex localisation" EXACT [GOC:mah]
synonym: "regulation of RNP localization" EXACT [GOC:obol]
is_a: GO:0060341 ! regulation of cellular localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071166 ! ribonucleoprotein complex localization
relationship: regulates GO:0071166 ! ribonucleoprotein complex localization
created_by: midori
creation_date: 2010-10-26T10:35:48Z

[Term]
id: GO:2000198
name: negative regulation of ribonucleoprotein complex localization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ribonucleoprotein complex localization." [GOC:mah]
synonym: "negative regulation of cellular ribonucleoprotein complex localization" EXACT [GOC:obol]
synonym: "negative regulation of establishment and maintenance of ribonucleoprotein complex localization" EXACT [GOC:obol]
synonym: "negative regulation of ribonucleoprotein complex localisation" EXACT [GOC:mah]
synonym: "negative regulation of RNP localization" EXACT [GOC:obol]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:2000197 ! regulation of ribonucleoprotein complex localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071166 ! ribonucleoprotein complex localization
relationship: negatively_regulates GO:0071166 ! ribonucleoprotein complex localization
created_by: midori
creation_date: 2010-10-26T10:35:52Z

[Term]
id: GO:2000199
name: positive regulation of ribonucleoprotein complex localization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ribonucleoprotein complex localization." [GOC:mah]
synonym: "positive regulation of cellular ribonucleoprotein complex localization" EXACT [GOC:obol]
synonym: "positive regulation of establishment and maintenance of ribonucleoprotein complex localization" EXACT [GOC:obol]
synonym: "positive regulation of ribonucleoprotein complex localisation" EXACT [GOC:mah]
synonym: "positive regulation of RNP localization" EXACT [GOC:obol]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:2000197 ! regulation of ribonucleoprotein complex localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071166 ! ribonucleoprotein complex localization
relationship: positively_regulates GO:0071166 ! ribonucleoprotein complex localization
created_by: midori
creation_date: 2010-10-26T10:35:55Z

[Term]
id: GO:2000200
name: regulation of ribosomal subunit export from nucleus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ribosomal subunit export from nucleus." [GOC:mah]
synonym: "regulation of ribosomal subunit export from cell nucleus" EXACT [GOC:obol]
synonym: "regulation of ribosomal subunit export out of nucleus" EXACT [GOC:obol]
synonym: "regulation of ribosomal subunit transport from nucleus to cytoplasm" EXACT [GOC:obol]
synonym: "regulation of ribosomal subunit-nucleus export" EXACT [GOC:obol]
synonym: "regulation of ribosome export from nucleus" RELATED [GOC:obol]
is_a: GO:0046822 ! regulation of nucleocytoplasmic transport
is_a: GO:0090069 ! regulation of ribosome biogenesis
is_a: GO:2000197 ! regulation of ribonucleoprotein complex localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000054 ! ribosomal subunit export from nucleus
relationship: regulates GO:0000054 ! ribosomal subunit export from nucleus
created_by: midori
creation_date: 2010-10-26T10:44:27Z

[Term]
id: GO:2000201
name: negative regulation of ribosomal subunit export from nucleus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ribosomal subunit export from nucleus." [GOC:mah]
synonym: "negative regulation of ribosomal subunit export from cell nucleus" EXACT [GOC:obol]
synonym: "negative regulation of ribosomal subunit export out of nucleus" EXACT [GOC:obol]
synonym: "negative regulation of ribosomal subunit transport from nucleus to cytoplasm" EXACT [GOC:obol]
synonym: "negative regulation of ribosomal subunit-nucleus export" EXACT [GOC:obol]
synonym: "negative regulation of ribosome export from nucleus" RELATED [GOC:obol]
is_a: GO:0046823 ! negative regulation of nucleocytoplasmic transport
is_a: GO:0090071 ! negative regulation of ribosome biogenesis
is_a: GO:2000198 ! negative regulation of ribonucleoprotein complex localization
is_a: GO:2000200 ! regulation of ribosomal subunit export from nucleus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000054 ! ribosomal subunit export from nucleus
relationship: negatively_regulates GO:0000054 ! ribosomal subunit export from nucleus
created_by: midori
creation_date: 2010-10-26T10:44:32Z

[Term]
id: GO:2000202
name: positive regulation of ribosomal subunit export from nucleus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ribosomal subunit export from nucleus." [GOC:mah]
synonym: "positive regulation of ribosomal subunit export from cell nucleus" EXACT [GOC:obol]
synonym: "positive regulation of ribosomal subunit export out of nucleus" EXACT [GOC:obol]
synonym: "positive regulation of ribosomal subunit transport from nucleus to cytoplasm" EXACT [GOC:obol]
synonym: "positive regulation of ribosomal subunit-nucleus export" EXACT [GOC:obol]
synonym: "positive regulation of ribosome export from nucleus" RELATED [GOC:obol]
is_a: GO:0046824 ! positive regulation of nucleocytoplasmic transport
is_a: GO:0090070 ! positive regulation of ribosome biogenesis
is_a: GO:2000199 ! positive regulation of ribonucleoprotein complex localization
is_a: GO:2000200 ! regulation of ribosomal subunit export from nucleus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000054 ! ribosomal subunit export from nucleus
relationship: positively_regulates GO:0000054 ! ribosomal subunit export from nucleus
created_by: midori
creation_date: 2010-10-26T10:44:36Z

[Term]
id: GO:2000203
name: regulation of ribosomal large subunit export from nucleus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ribosomal large subunit export from nucleus." [GOC:mah]
synonym: "regulation of 50S ribosomal subunit export from nucleus" RELATED [GOC:obol]
synonym: "regulation of 60S ribosomal subunit export from nucleus" RELATED [GOC:obol]
synonym: "regulation of ribosomal large subunit export from cell nucleus" EXACT [GOC:obol]
synonym: "regulation of ribosomal large subunit export out of nucleus" EXACT [GOC:obol]
synonym: "regulation of ribosomal large subunit transport from nucleus to cytoplasm" EXACT [GOC:obol]
synonym: "regulation of ribosomal large subunit-nucleus export" EXACT [GOC:obol]
is_a: GO:2000200 ! regulation of ribosomal subunit export from nucleus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000055 ! ribosomal large subunit export from nucleus
relationship: regulates GO:0000055 ! ribosomal large subunit export from nucleus
created_by: midori
creation_date: 2010-10-26T10:52:36Z

[Term]
id: GO:2000204
name: negative regulation of ribosomal large subunit export from nucleus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ribosomal large subunit export from nucleus." [GOC:mah]
synonym: "negative regulation of 50S ribosomal subunit export from nucleus" RELATED [GOC:obol]
synonym: "negative regulation of 60S ribosomal subunit export from nucleus" RELATED [GOC:obol]
synonym: "negative regulation of ribosomal large subunit export from cell nucleus" EXACT [GOC:obol]
synonym: "negative regulation of ribosomal large subunit export out of nucleus" EXACT [GOC:obol]
synonym: "negative regulation of ribosomal large subunit transport from nucleus to cytoplasm" EXACT [GOC:obol]
synonym: "negative regulation of ribosomal large subunit-nucleus export" EXACT [GOC:obol]
is_a: GO:2000201 ! negative regulation of ribosomal subunit export from nucleus
is_a: GO:2000203 ! regulation of ribosomal large subunit export from nucleus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000055 ! ribosomal large subunit export from nucleus
relationship: negatively_regulates GO:0000055 ! ribosomal large subunit export from nucleus
created_by: midori
creation_date: 2010-10-26T10:52:39Z

[Term]
id: GO:2000205
name: positive regulation of ribosomal large subunit export from nucleus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ribosomal large subunit export from nucleus." [GOC:mah]
synonym: "positive regulation of 50S ribosomal subunit export from nucleus" RELATED [GOC:obol]
synonym: "positive regulation of 60S ribosomal subunit export from nucleus" RELATED [GOC:obol]
synonym: "positive regulation of ribosomal large subunit export from cell nucleus" EXACT [GOC:obol]
synonym: "positive regulation of ribosomal large subunit export out of nucleus" EXACT [GOC:obol]
synonym: "positive regulation of ribosomal large subunit transport from nucleus to cytoplasm" EXACT [GOC:obol]
synonym: "positive regulation of ribosomal large subunit-nucleus export" EXACT [GOC:obol]
is_a: GO:2000202 ! positive regulation of ribosomal subunit export from nucleus
is_a: GO:2000203 ! regulation of ribosomal large subunit export from nucleus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000055 ! ribosomal large subunit export from nucleus
relationship: positively_regulates GO:0000055 ! ribosomal large subunit export from nucleus
created_by: midori
creation_date: 2010-10-26T10:52:42Z

[Term]
id: GO:2000206
name: regulation of ribosomal small subunit export from nucleus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ribosomal small subunit export from nucleus." [GOC:mah]
synonym: "regulation of 30S ribosomal subunit export from nucleus" RELATED [GOC:obol]
synonym: "regulation of 40S ribosomal subunit export from nucleus" RELATED [GOC:obol]
synonym: "regulation of ribosomal small subunit export from cell nucleus" EXACT [GOC:obol]
synonym: "regulation of ribosomal small subunit export out of nucleus" EXACT [GOC:obol]
synonym: "regulation of ribosomal small subunit transport from nucleus to cytoplasm" EXACT [GOC:obol]
synonym: "regulation of ribosomal small subunit-nucleus export" EXACT [GOC:obol]
is_a: GO:2000200 ! regulation of ribosomal subunit export from nucleus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000056 ! ribosomal small subunit export from nucleus
relationship: regulates GO:0000056 ! ribosomal small subunit export from nucleus
created_by: midori
creation_date: 2010-10-26T10:54:09Z

[Term]
id: GO:2000207
name: negative regulation of ribosomal small subunit export from nucleus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ribosomal small subunit export from nucleus." [GOC:mah]
synonym: "negative regulation of 30S ribosomal subunit export from nucleus" RELATED [GOC:obol]
synonym: "negative regulation of 40S ribosomal subunit export from nucleus" RELATED [GOC:obol]
synonym: "negative regulation of ribosomal small subunit export from cell nucleus" EXACT [GOC:obol]
synonym: "negative regulation of ribosomal small subunit export out of nucleus" EXACT [GOC:obol]
synonym: "negative regulation of ribosomal small subunit transport from nucleus to cytoplasm" EXACT [GOC:obol]
synonym: "negative regulation of ribosomal small subunit-nucleus export" EXACT [GOC:obol]
is_a: GO:2000201 ! negative regulation of ribosomal subunit export from nucleus
is_a: GO:2000206 ! regulation of ribosomal small subunit export from nucleus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000056 ! ribosomal small subunit export from nucleus
relationship: negatively_regulates GO:0000056 ! ribosomal small subunit export from nucleus
created_by: midori
creation_date: 2010-10-26T10:54:14Z

[Term]
id: GO:2000208
name: positive regulation of ribosomal small subunit export from nucleus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ribosomal small subunit export from nucleus." [GOC:mah]
synonym: "positive regulation of 30S ribosomal subunit export from nucleus" RELATED [GOC:obol]
synonym: "positive regulation of 40S ribosomal subunit export from nucleus" RELATED [GOC:obol]
synonym: "positive regulation of ribosomal small subunit export from cell nucleus" EXACT [GOC:obol]
synonym: "positive regulation of ribosomal small subunit export out of nucleus" EXACT [GOC:obol]
synonym: "positive regulation of ribosomal small subunit transport from nucleus to cytoplasm" EXACT [GOC:obol]
synonym: "positive regulation of ribosomal small subunit-nucleus export" EXACT [GOC:obol]
is_a: GO:2000202 ! positive regulation of ribosomal subunit export from nucleus
is_a: GO:2000206 ! regulation of ribosomal small subunit export from nucleus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000056 ! ribosomal small subunit export from nucleus
relationship: positively_regulates GO:0000056 ! ribosomal small subunit export from nucleus
created_by: midori
creation_date: 2010-10-26T10:54:16Z

[Term]
id: GO:2000209
name: regulation of anoikis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of anoikis." [GOC:mah]
synonym: "regulation of detachment induced cell death" EXACT [GOC:obol]
synonym: "regulation of suspension induced apoptosis" EXACT [GOC:obol]
is_a: GO:0042981 ! regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043276 ! anoikis
relationship: regulates GO:0043276 ! anoikis
created_by: midori
creation_date: 2010-11-03T02:00:33Z

[Term]
id: GO:2000210
name: positive regulation of anoikis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of anoikis." [GOC:mah]
synonym: "positive regulation of detachment induced cell death" EXACT [GOC:obol]
synonym: "positive regulation of suspension induced apoptosis" EXACT [GOC:obol]
is_a: GO:0043065 ! positive regulation of apoptotic process
is_a: GO:2000209 ! regulation of anoikis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043276 ! anoikis
relationship: positively_regulates GO:0043276 ! anoikis
created_by: midori
creation_date: 2010-11-03T02:00:36Z

[Term]
id: GO:2000211
name: regulation of glutamate metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glutamate metabolic process." [GOC:sl]
synonym: "regulation of glutamate metabolism" EXACT [GOC:obol]
synonym: "regulation of glutamic acid metabolic process" EXACT [GOC:obol]
synonym: "regulation of glutamic acid metabolism" EXACT [GOC:obol]
is_a: GO:0000820 ! regulation of glutamine family amino acid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006536 ! glutamate metabolic process
relationship: regulates GO:0006536 ! glutamate metabolic process
created_by: midori
creation_date: 2010-11-03T02:43:51Z

[Term]
id: GO:2000212
name: negative regulation of glutamate metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of glutamate metabolic process." [GOC:sl]
synonym: "negative regulation of glutamate metabolism" EXACT [GOC:obol]
synonym: "negative regulation of glutamic acid metabolic process" EXACT [GOC:obol]
synonym: "negative regulation of glutamic acid metabolism" EXACT [GOC:obol]
is_a: GO:0045763 ! negative regulation of cellular amino acid metabolic process
is_a: GO:2000211 ! regulation of glutamate metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006536 ! glutamate metabolic process
relationship: negatively_regulates GO:0006536 ! glutamate metabolic process
created_by: midori
creation_date: 2010-11-03T02:43:55Z

[Term]
id: GO:2000213
name: positive regulation of glutamate metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glutamate metabolic process." [GOC:sl]
synonym: "positive regulation of glutamate metabolism" EXACT [GOC:obol]
synonym: "positive regulation of glutamic acid metabolic process" EXACT [GOC:obol]
synonym: "positive regulation of glutamic acid metabolism" EXACT [GOC:obol]
is_a: GO:0045764 ! positive regulation of cellular amino acid metabolic process
is_a: GO:2000211 ! regulation of glutamate metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006536 ! glutamate metabolic process
relationship: positively_regulates GO:0006536 ! glutamate metabolic process
created_by: midori
creation_date: 2010-11-03T02:43:59Z

[Term]
id: GO:2000214
name: regulation of proline metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of proline metabolic process." [GOC:sl]
synonym: "regulation of proline metabolism" EXACT [GOC:obol]
is_a: GO:0000820 ! regulation of glutamine family amino acid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006560 ! proline metabolic process
relationship: regulates GO:0006560 ! proline metabolic process
created_by: midori
creation_date: 2010-11-03T02:45:20Z

[Term]
id: GO:2000215
name: negative regulation of proline metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of proline metabolic process." [GOC:sl]
synonym: "negative regulation of proline metabolism" EXACT [GOC:obol]
is_a: GO:0045763 ! negative regulation of cellular amino acid metabolic process
is_a: GO:2000214 ! regulation of proline metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006560 ! proline metabolic process
relationship: negatively_regulates GO:0006560 ! proline metabolic process
created_by: midori
creation_date: 2010-11-03T02:45:24Z

[Term]
id: GO:2000216
name: positive regulation of proline metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of proline metabolic process." [GOC:sl]
synonym: "positive regulation of proline metabolism" EXACT [GOC:obol]
is_a: GO:0045764 ! positive regulation of cellular amino acid metabolic process
is_a: GO:2000214 ! regulation of proline metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006560 ! proline metabolic process
relationship: positively_regulates GO:0006560 ! proline metabolic process
created_by: midori
creation_date: 2010-11-03T02:45:27Z

[Term]
id: GO:2000217
name: regulation of invasive growth in response to glucose limitation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of invasive growth in response to glucose limitation." [GOC:mah]
synonym: "regulation of colony morphology" RELATED [GOC:obol]
is_a: GO:0070784 ! regulation of growth of unicellular organism as a thread of attached cells
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001403 ! invasive growth in response to glucose limitation
relationship: regulates GO:0001403 ! invasive growth in response to glucose limitation
created_by: midori
creation_date: 2010-11-03T04:35:56Z

[Term]
id: GO:2000218
name: negative regulation of invasive growth in response to glucose limitation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of invasive growth in response to glucose limitation." [GOC:mah]
synonym: "negative regulation of colony morphology" RELATED [GOC:obol]
is_a: GO:0070785 ! negative regulation of growth of unicellular organism as a thread of attached cells
is_a: GO:2000217 ! regulation of invasive growth in response to glucose limitation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001403 ! invasive growth in response to glucose limitation
relationship: negatively_regulates GO:0001403 ! invasive growth in response to glucose limitation
created_by: midori
creation_date: 2010-11-03T04:36:00Z

[Term]
id: GO:2000219
name: positive regulation of invasive growth in response to glucose limitation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of invasive growth in response to glucose limitation." [GOC:mah]
synonym: "positive regulation of colony morphology" RELATED [GOC:obol]
is_a: GO:0070786 ! positive regulation of growth of unicellular organism as a thread of attached cells
is_a: GO:2000217 ! regulation of invasive growth in response to glucose limitation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001403 ! invasive growth in response to glucose limitation
relationship: positively_regulates GO:0001403 ! invasive growth in response to glucose limitation
created_by: midori
creation_date: 2010-11-03T04:36:02Z

[Term]
id: GO:2000220
name: regulation of pseudohyphal growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pseudohyphal growth." [GOC:mah]
is_a: GO:0001558 ! regulation of cell growth
is_a: GO:0070784 ! regulation of growth of unicellular organism as a thread of attached cells
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007124 ! pseudohyphal growth
relationship: regulates GO:0007124 ! pseudohyphal growth
created_by: midori
creation_date: 2010-11-03T04:36:56Z

[Term]
id: GO:2000221
name: negative regulation of pseudohyphal growth
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pseudohyphal growth." [GOC:mah]
is_a: GO:0030308 ! negative regulation of cell growth
is_a: GO:0070785 ! negative regulation of growth of unicellular organism as a thread of attached cells
is_a: GO:2000220 ! regulation of pseudohyphal growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007124 ! pseudohyphal growth
relationship: negatively_regulates GO:0007124 ! pseudohyphal growth
created_by: midori
creation_date: 2010-11-03T04:37:00Z

[Term]
id: GO:2000222
name: positive regulation of pseudohyphal growth
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pseudohyphal growth." [GOC:mah]
is_a: GO:0030307 ! positive regulation of cell growth
is_a: GO:0070786 ! positive regulation of growth of unicellular organism as a thread of attached cells
is_a: GO:2000220 ! regulation of pseudohyphal growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007124 ! pseudohyphal growth
relationship: positively_regulates GO:0007124 ! pseudohyphal growth
created_by: midori
creation_date: 2010-11-03T04:37:03Z

[Term]
id: GO:2000223
name: regulation of BMP signaling pathway involved in heart jogging
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of BMP signaling pathway involved in heart jogging." [GOC:BHF]
synonym: "regulation of BMP signalling pathway involved in heart jogging pathway involved in somitogenesis" EXACT [GOC:mah]
is_a: GO:0030510 ! regulation of BMP signaling pathway
is_a: GO:0045995 ! regulation of embryonic development
is_a: GO:2000826 ! regulation of heart morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003303 ! BMP signaling pathway involved in heart jogging
relationship: regulates GO:0003303 ! BMP signaling pathway involved in heart jogging
created_by: vk
creation_date: 2010-11-04T02:44:01Z

[Term]
id: GO:2000224
name: regulation of testosterone biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of testosterone biosynthetic process." [GOC:obol, GOC:yaf]
is_a: GO:0010566 ! regulation of ketone biosynthetic process
is_a: GO:0046885 ! regulation of hormone biosynthetic process
is_a: GO:0050810 ! regulation of steroid biosynthetic process
is_a: GO:1902930 ! regulation of alcohol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061370 ! testosterone biosynthetic process
relationship: regulates GO:0061370 ! testosterone biosynthetic process
created_by: yaf
creation_date: 2010-11-09T10:38:33Z

[Term]
id: GO:2000225
name: negative regulation of testosterone biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of testosterone biosynthetic process." [GOC:obol, GOC:yaf]
is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process
is_a: GO:2000180 ! negative regulation of androgen biosynthetic process
is_a: GO:2000224 ! regulation of testosterone biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061370 ! testosterone biosynthetic process
relationship: negatively_regulates GO:0061370 ! testosterone biosynthetic process
created_by: yaf
creation_date: 2010-11-09T10:38:37Z

[Term]
id: GO:2000226
name: regulation of pancreatic A cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pancreatic A cell differentiation." [GOC:mah]
synonym: "regulation of pancreatic alpha cell differentiation" EXACT [GOC:obol]
is_a: GO:0030856 ! regulation of epithelial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003310 ! pancreatic A cell differentiation
relationship: regulates GO:0003310 ! pancreatic A cell differentiation
created_by: midori
creation_date: 2010-11-09T03:43:37Z

[Term]
id: GO:2000227
name: negative regulation of pancreatic A cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic A cell differentiation." [GOC:mah]
synonym: "negative regulation of pancreatic alpha cell differentiation" EXACT [GOC:obol]
is_a: GO:0030857 ! negative regulation of epithelial cell differentiation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000226 ! regulation of pancreatic A cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003310 ! pancreatic A cell differentiation
relationship: negatively_regulates GO:0003310 ! pancreatic A cell differentiation
created_by: midori
creation_date: 2010-11-09T03:43:40Z

[Term]
id: GO:2000228
name: positive regulation of pancreatic A cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pancreatic A cell differentiation." [GOC:mah]
synonym: "positive regulation of pancreatic alpha cell differentiation" EXACT [GOC:obol]
is_a: GO:0030858 ! positive regulation of epithelial cell differentiation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000226 ! regulation of pancreatic A cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003310 ! pancreatic A cell differentiation
relationship: positively_regulates GO:0003310 ! pancreatic A cell differentiation
created_by: midori
creation_date: 2010-11-09T03:43:42Z

[Term]
id: GO:2000229
name: regulation of pancreatic stellate cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pancreatic stellate cell proliferation." [GOC:mah]
is_a: GO:0048145 ! regulation of fibroblast proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072343 ! pancreatic stellate cell proliferation
relationship: regulates GO:0072343 ! pancreatic stellate cell proliferation
created_by: midori
creation_date: 2010-11-09T03:45:18Z

[Term]
id: GO:2000230
name: negative regulation of pancreatic stellate cell proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic stellate cell proliferation." [GOC:mah]
is_a: GO:0048147 ! negative regulation of fibroblast proliferation
is_a: GO:2000229 ! regulation of pancreatic stellate cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072343 ! pancreatic stellate cell proliferation
relationship: negatively_regulates GO:0072343 ! pancreatic stellate cell proliferation
created_by: midori
creation_date: 2010-11-09T03:45:21Z

[Term]
id: GO:2000231
name: positive regulation of pancreatic stellate cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pancreatic stellate cell proliferation." [GOC:mah]
is_a: GO:0048146 ! positive regulation of fibroblast proliferation
is_a: GO:2000229 ! regulation of pancreatic stellate cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072343 ! pancreatic stellate cell proliferation
relationship: positively_regulates GO:0072343 ! pancreatic stellate cell proliferation
created_by: midori
creation_date: 2010-11-09T03:45:23Z

[Term]
id: GO:2000232
name: regulation of rRNA processing
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of rRNA processing." [GOC:mah]
synonym: "regulation of 35S primary transcript processing" RELATED [GOC:obol]
is_a: GO:0010468 ! regulation of gene expression
is_a: GO:0051252 ! regulation of RNA metabolic process
is_a: GO:0090069 ! regulation of ribosome biogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006364 ! rRNA processing
relationship: regulates GO:0006364 ! rRNA processing
created_by: midori
creation_date: 2010-11-10T12:11:29Z

[Term]
id: GO:2000233
name: negative regulation of rRNA processing
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of rRNA processing." [GOC:mah]
synonym: "negative regulation of 35S primary transcript processing" RELATED [GOC:obol]
is_a: GO:0010629 ! negative regulation of gene expression
is_a: GO:0051253 ! negative regulation of RNA metabolic process
is_a: GO:0090071 ! negative regulation of ribosome biogenesis
is_a: GO:2000232 ! regulation of rRNA processing
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006364 ! rRNA processing
relationship: negatively_regulates GO:0006364 ! rRNA processing
created_by: midori
creation_date: 2010-11-10T12:11:33Z

[Term]
id: GO:2000234
name: positive regulation of rRNA processing
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of rRNA processing." [GOC:mah]
synonym: "positive regulation of 35S primary transcript processing" RELATED [GOC:obol]
is_a: GO:0010628 ! positive regulation of gene expression
is_a: GO:0051254 ! positive regulation of RNA metabolic process
is_a: GO:0090070 ! positive regulation of ribosome biogenesis
is_a: GO:2000232 ! regulation of rRNA processing
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006364 ! rRNA processing
relationship: positively_regulates GO:0006364 ! rRNA processing
created_by: midori
creation_date: 2010-11-10T12:11:36Z

[Term]
id: GO:2000235
name: regulation of tRNA processing
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tRNA processing." [GOC:mah]
synonym: "regulation of tRNA maturation" EXACT [GOC:obol]
is_a: GO:0010468 ! regulation of gene expression
is_a: GO:1903326 ! regulation of tRNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008033 ! tRNA processing
relationship: regulates GO:0008033 ! tRNA processing
created_by: midori
creation_date: 2010-11-10T12:15:08Z

[Term]
id: GO:2000236
name: negative regulation of tRNA processing
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of tRNA processing." [GOC:mah]
synonym: "negative regulation of tRNA maturation" EXACT [GOC:obol]
is_a: GO:0010629 ! negative regulation of gene expression
is_a: GO:1903327 ! negative regulation of tRNA metabolic process
is_a: GO:2000235 ! regulation of tRNA processing
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008033 ! tRNA processing
relationship: negatively_regulates GO:0008033 ! tRNA processing
created_by: midori
creation_date: 2010-11-10T12:15:13Z

[Term]
id: GO:2000237
name: positive regulation of tRNA processing
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tRNA processing." [GOC:mah]
synonym: "positive regulation of tRNA maturation" EXACT [GOC:obol]
is_a: GO:0010628 ! positive regulation of gene expression
is_a: GO:1903328 ! positive regulation of tRNA metabolic process
is_a: GO:2000235 ! regulation of tRNA processing
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008033 ! tRNA processing
relationship: positively_regulates GO:0008033 ! tRNA processing
created_by: midori
creation_date: 2010-11-10T12:15:17Z

[Term]
id: GO:2000238
name: regulation of tRNA export from nucleus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tRNA export from nucleus." [GOC:mah]
synonym: "regulation of tRNA export from cell nucleus" EXACT [GOC:obol]
synonym: "regulation of tRNA export out of nucleus" EXACT [GOC:obol]
synonym: "regulation of tRNA transport from nucleus to cytoplasm" EXACT [GOC:obol]
synonym: "regulation of tRNA-nucleus export" EXACT [GOC:obol]
is_a: GO:0046831 ! regulation of RNA export from nucleus
is_a: GO:2000197 ! regulation of ribonucleoprotein complex localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006409 ! tRNA export from nucleus
relationship: regulates GO:0006409 ! tRNA export from nucleus
created_by: midori
creation_date: 2010-11-10T12:39:33Z

[Term]
id: GO:2000239
name: negative regulation of tRNA export from nucleus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of tRNA export from nucleus." [GOC:mah]
synonym: "negative regulation of tRNA export from cell nucleus" EXACT [GOC:obol]
synonym: "negative regulation of tRNA export out of nucleus" EXACT [GOC:obol]
synonym: "negative regulation of tRNA transport from nucleus to cytoplasm" EXACT [GOC:obol]
synonym: "negative regulation of tRNA-nucleus export" EXACT [GOC:obol]
is_a: GO:0046832 ! negative regulation of RNA export from nucleus
is_a: GO:2000198 ! negative regulation of ribonucleoprotein complex localization
is_a: GO:2000238 ! regulation of tRNA export from nucleus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006409 ! tRNA export from nucleus
relationship: negatively_regulates GO:0006409 ! tRNA export from nucleus
created_by: midori
creation_date: 2010-11-10T12:39:36Z

[Term]
id: GO:2000240
name: positive regulation of tRNA export from nucleus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tRNA export from nucleus." [GOC:mah]
synonym: "positive regulation of tRNA export from cell nucleus" EXACT [GOC:obol]
synonym: "positive regulation of tRNA export out of nucleus" EXACT [GOC:obol]
synonym: "positive regulation of tRNA transport from nucleus to cytoplasm" EXACT [GOC:obol]
synonym: "positive regulation of tRNA-nucleus export" EXACT [GOC:obol]
is_a: GO:0046833 ! positive regulation of RNA export from nucleus
is_a: GO:2000199 ! positive regulation of ribonucleoprotein complex localization
is_a: GO:2000238 ! regulation of tRNA export from nucleus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006409 ! tRNA export from nucleus
relationship: positively_regulates GO:0006409 ! tRNA export from nucleus
created_by: midori
creation_date: 2010-11-10T12:39:38Z

[Term]
id: GO:2000241
name: regulation of reproductive process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of reproductive process." [GOC:mah]
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0022414 ! reproductive process
relationship: regulates GO:0022414 ! reproductive process
created_by: midori
creation_date: 2010-11-10T02:44:02Z

[Term]
id: GO:2000242
name: negative regulation of reproductive process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process." [GOC:mah]
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0022414 ! reproductive process
relationship: negatively_regulates GO:0022414 ! reproductive process
created_by: midori
creation_date: 2010-11-10T02:44:05Z

[Term]
id: GO:2000243
name: positive regulation of reproductive process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of reproductive process." [GOC:mah]
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0022414 ! reproductive process
relationship: positively_regulates GO:0022414 ! reproductive process
created_by: midori
creation_date: 2010-11-10T02:44:08Z

[Term]
id: GO:2000244
name: regulation of FtsZ-dependent cytokinesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of FtsZ-dependent cytokinesis." [GOC:mah]
synonym: "regulation of prokaryote-type cytokinesis" RELATED [GOC:obol]
synonym: "regulation of prokaryotic fission" RELATED [GOC:obol]
is_a: GO:0032465 ! regulation of cytokinesis
is_a: GO:1903664 ! regulation of asexual reproduction
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043093 ! FtsZ-dependent cytokinesis
relationship: regulates GO:0043093 ! FtsZ-dependent cytokinesis
created_by: midori
creation_date: 2010-11-10T02:46:36Z

[Term]
id: GO:2000245
name: negative regulation of FtsZ-dependent cytokinesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Ftsz-dependent cytokinesis." [GOC:mah]
synonym: "negative regulation of prokaryote-type cytokinesis" RELATED [GOC:obol]
synonym: "negative regulation of prokaryotic fission" RELATED [GOC:obol]
is_a: GO:0032466 ! negative regulation of cytokinesis
is_a: GO:1903665 ! negative regulation of asexual reproduction
is_a: GO:2000242 ! negative regulation of reproductive process
is_a: GO:2000244 ! regulation of FtsZ-dependent cytokinesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043093 ! FtsZ-dependent cytokinesis
relationship: negatively_regulates GO:0043093 ! FtsZ-dependent cytokinesis
created_by: midori
creation_date: 2010-11-10T02:46:39Z

[Term]
id: GO:2000246
name: positive regulation of FtsZ-dependent cytokinesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of Ftsz-dependent cytokinesis." [GOC:mah]
synonym: "positive regulation of prokaryote-type cytokinesis" RELATED [GOC:obol]
synonym: "positive regulation of prokaryotic fission" RELATED [GOC:obol]
is_a: GO:0032467 ! positive regulation of cytokinesis
is_a: GO:1903666 ! positive regulation of asexual reproduction
is_a: GO:2000243 ! positive regulation of reproductive process
is_a: GO:2000244 ! regulation of FtsZ-dependent cytokinesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043093 ! FtsZ-dependent cytokinesis
relationship: positively_regulates GO:0043093 ! FtsZ-dependent cytokinesis
created_by: midori
creation_date: 2010-11-10T02:46:41Z

[Term]
id: GO:2000247
name: positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment or maintenance of bipolar cell polarity regulating cell shape." [GOC:obol]
is_a: GO:2000100 ! regulation of establishment or maintenance of bipolar cell polarity regulating cell shape
is_a: GO:2000771 ! positive regulation of establishment or maintenance of cell polarity regulating cell shape
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061246 ! establishment or maintenance of bipolar cell polarity regulating cell shape
relationship: positively_regulates GO:0061246 ! establishment or maintenance of bipolar cell polarity regulating cell shape
created_by: vw
creation_date: 2010-11-11T11:39:34Z

[Term]
id: GO:2000248
name: negative regulation of establishment or maintenance of neuroblast polarity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or maintenance of neuroblast polarity." [GOC:obol]
synonym: "negative regulation of establishment and/or maintenance of neuroblast cell polarity" EXACT [GOC:obol]
is_a: GO:0007406 ! negative regulation of neuroblast proliferation
is_a: GO:0010454 ! negative regulation of cell fate commitment
is_a: GO:0032878 ! regulation of establishment or maintenance of cell polarity
is_a: GO:0045769 ! negative regulation of asymmetric cell division
is_a: GO:1904676 ! negative regulation of somatic stem cell division
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045196 ! establishment or maintenance of neuroblast polarity
relationship: negatively_regulates GO:0045196 ! establishment or maintenance of neuroblast polarity
created_by: vw
creation_date: 2010-11-11T11:40:34Z

[Term]
id: GO:2000249
name: regulation of actin cytoskeleton reorganization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of actin cytoskeleton reorganization." [GOC:BHF]
synonym: "regulation of actin cytoskeleton remodeling" EXACT [GOC:obol]
synonym: "regulation of actin cytoskeleton reorganisation" EXACT [GOC:obol]
is_a: GO:0032956 ! regulation of actin cytoskeleton organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031532 ! actin cytoskeleton reorganization
relationship: regulates GO:0031532 ! actin cytoskeleton reorganization
created_by: vk
creation_date: 2010-11-11T01:25:26Z

[Term]
id: GO:2000250
name: negative regulation of actin cytoskeleton reorganization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of actin cytoskeleton reorganization." [GOC:BHF]
synonym: "negative regulation of actin cytoskeleton remodeling" EXACT [GOC:obol]
synonym: "negative regulation of actin cytoskeleton reorganisation" EXACT [GOC:obol]
is_a: GO:0051494 ! negative regulation of cytoskeleton organization
is_a: GO:2000249 ! regulation of actin cytoskeleton reorganization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0031532 ! actin cytoskeleton reorganization
relationship: negatively_regulates GO:0031532 ! actin cytoskeleton reorganization
created_by: vk
creation_date: 2010-11-11T01:25:29Z

[Term]
id: GO:2000251
name: positive regulation of actin cytoskeleton reorganization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of actin cytoskeleton reorganization." [GOC:BHF]
synonym: "positive regulation of actin cytoskeleton remodeling" EXACT [GOC:obol]
synonym: "positive regulation of actin cytoskeleton reorganisation" EXACT [GOC:obol]
is_a: GO:0051495 ! positive regulation of cytoskeleton organization
is_a: GO:2000249 ! regulation of actin cytoskeleton reorganization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0031532 ! actin cytoskeleton reorganization
relationship: positively_regulates GO:0031532 ! actin cytoskeleton reorganization
created_by: vk
creation_date: 2010-11-11T01:25:32Z

[Term]
id: GO:2000252
name: negative regulation of feeding behavior
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of feeding behavior." [GOC:obol]
synonym: "negative regulation of behavioral response to food" EXACT [GOC:obol]
synonym: "negative regulation of behavioural response to food" EXACT [GOC:obol]
synonym: "negative regulation of drinking" RELATED [GOC:obol]
synonym: "negative regulation of eating" RELATED [GOC:obol]
synonym: "negative regulation of feeding behaviour" EXACT [GOC:obol]
is_a: GO:0048521 ! negative regulation of behavior
is_a: GO:0060259 ! regulation of feeding behavior
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007631 ! feeding behavior
relationship: negatively_regulates GO:0007631 ! feeding behavior
created_by: yaf
creation_date: 2010-11-18T11:24:14Z

[Term]
id: GO:2000253
name: positive regulation of feeding behavior
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of feeding behavior." [GOC:obol]
synonym: "positive regulation of behavioral response to food" EXACT [GOC:obol]
synonym: "positive regulation of behavioural response to food" EXACT [GOC:obol]
synonym: "positive regulation of drinking" RELATED [GOC:obol]
synonym: "positive regulation of eating" RELATED [GOC:obol]
synonym: "positive regulation of feeding behaviour" EXACT [GOC:obol]
is_a: GO:0048520 ! positive regulation of behavior
is_a: GO:0060259 ! regulation of feeding behavior
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007631 ! feeding behavior
relationship: positively_regulates GO:0007631 ! feeding behavior
created_by: yaf
creation_date: 2010-11-18T11:24:18Z

[Term]
id: GO:2000254
name: regulation of male germ cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of male germ cell proliferation." [GOC:obol]
is_a: GO:0042127 ! regulation of cell proliferation
is_a: GO:0043900 ! regulation of multi-organism process
is_a: GO:0051239 ! regulation of multicellular organismal process
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002176 ! male germ cell proliferation
relationship: regulates GO:0002176 ! male germ cell proliferation
created_by: dph
creation_date: 2010-11-18T09:29:44Z

[Term]
id: GO:2000255
name: negative regulation of male germ cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of male germ cell proliferation." [GOC:obol]
is_a: GO:0008285 ! negative regulation of cell proliferation
is_a: GO:0043901 ! negative regulation of multi-organism process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000242 ! negative regulation of reproductive process
is_a: GO:2000254 ! regulation of male germ cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002176 ! male germ cell proliferation
relationship: negatively_regulates GO:0002176 ! male germ cell proliferation
created_by: dph
creation_date: 2010-11-18T09:29:47Z

[Term]
id: GO:2000256
name: positive regulation of male germ cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of male germ cell proliferation." [GOC:obol]
is_a: GO:0008284 ! positive regulation of cell proliferation
is_a: GO:0043902 ! positive regulation of multi-organism process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000243 ! positive regulation of reproductive process
is_a: GO:2000254 ! regulation of male germ cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002176 ! male germ cell proliferation
relationship: positively_regulates GO:0002176 ! male germ cell proliferation
created_by: dph
creation_date: 2010-11-18T09:29:50Z

[Term]
id: GO:2000257
name: regulation of protein activation cascade
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein activation cascade." [GOC:mah]
synonym: "regulation of protein activation pathway" EXACT [GOC:obol]
synonym: "regulation of protein activitory cascade" EXACT [GOC:obol]
is_a: GO:0048583 ! regulation of response to stimulus
is_a: GO:0051246 ! regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072376 ! protein activation cascade
relationship: regulates GO:0072376 ! protein activation cascade
created_by: midori
creation_date: 2010-11-23T11:33:46Z

[Term]
id: GO:2000258
name: negative regulation of protein activation cascade
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein activation cascade." [GOC:mah]
synonym: "negative regulation of protein activation pathway" EXACT [GOC:obol]
synonym: "negative regulation of protein activitory cascade" EXACT [GOC:obol]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:0051248 ! negative regulation of protein metabolic process
is_a: GO:2000257 ! regulation of protein activation cascade
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072376 ! protein activation cascade
relationship: negatively_regulates GO:0072376 ! protein activation cascade
created_by: midori
creation_date: 2010-11-23T11:33:51Z

[Term]
id: GO:2000259
name: positive regulation of protein activation cascade
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein activation cascade." [GOC:mah]
synonym: "positive regulation of protein activation pathway" EXACT [GOC:obol]
synonym: "positive regulation of protein activitory cascade" EXACT [GOC:obol]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:0051247 ! positive regulation of protein metabolic process
is_a: GO:2000257 ! regulation of protein activation cascade
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072376 ! protein activation cascade
relationship: positively_regulates GO:0072376 ! protein activation cascade
created_by: midori
creation_date: 2010-11-23T11:33:55Z

[Term]
id: GO:2000260
name: regulation of blood coagulation, common pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of blood coagulation, common pathway." [GOC:mah]
is_a: GO:0030193 ! regulation of blood coagulation
is_a: GO:2000257 ! regulation of protein activation cascade
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072377 ! blood coagulation, common pathway
relationship: regulates GO:0072377 ! blood coagulation, common pathway
created_by: midori
creation_date: 2010-11-23T11:42:40Z

[Term]
id: GO:2000261
name: negative regulation of blood coagulation, common pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation, common pathway." [GOC:mah]
is_a: GO:0030195 ! negative regulation of blood coagulation
is_a: GO:2000258 ! negative regulation of protein activation cascade
is_a: GO:2000260 ! regulation of blood coagulation, common pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072377 ! blood coagulation, common pathway
relationship: negatively_regulates GO:0072377 ! blood coagulation, common pathway
created_by: midori
creation_date: 2010-11-23T11:42:44Z

[Term]
id: GO:2000262
name: positive regulation of blood coagulation, common pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of blood coagulation, common pathway." [GOC:mah]
is_a: GO:0030194 ! positive regulation of blood coagulation
is_a: GO:2000259 ! positive regulation of protein activation cascade
is_a: GO:2000260 ! regulation of blood coagulation, common pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072377 ! blood coagulation, common pathway
relationship: positively_regulates GO:0072377 ! blood coagulation, common pathway
created_by: midori
creation_date: 2010-11-23T11:42:48Z

[Term]
id: GO:2000263
name: regulation of blood coagulation, extrinsic pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of blood coagulation, extrinsic pathway." [GOC:mah]
is_a: GO:0030193 ! regulation of blood coagulation
is_a: GO:2000257 ! regulation of protein activation cascade
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007598 ! blood coagulation, extrinsic pathway
relationship: regulates GO:0007598 ! blood coagulation, extrinsic pathway
created_by: midori
creation_date: 2010-11-23T11:44:35Z

[Term]
id: GO:2000264
name: negative regulation of blood coagulation, extrinsic pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation, extrinsic pathway." [GOC:mah]
is_a: GO:0030195 ! negative regulation of blood coagulation
is_a: GO:2000258 ! negative regulation of protein activation cascade
is_a: GO:2000263 ! regulation of blood coagulation, extrinsic pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007598 ! blood coagulation, extrinsic pathway
relationship: negatively_regulates GO:0007598 ! blood coagulation, extrinsic pathway
created_by: midori
creation_date: 2010-11-23T11:44:42Z

[Term]
id: GO:2000265
name: positive regulation of blood coagulation, extrinsic pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of blood coagulation, extrinsic pathway." [GOC:mah]
is_a: GO:0030194 ! positive regulation of blood coagulation
is_a: GO:2000259 ! positive regulation of protein activation cascade
is_a: GO:2000263 ! regulation of blood coagulation, extrinsic pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007598 ! blood coagulation, extrinsic pathway
relationship: positively_regulates GO:0007598 ! blood coagulation, extrinsic pathway
created_by: midori
creation_date: 2010-11-23T11:44:46Z

[Term]
id: GO:2000266
name: regulation of blood coagulation, intrinsic pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of blood coagulation, intrinsic pathway." [GOC:mah]
is_a: GO:0030193 ! regulation of blood coagulation
is_a: GO:2000257 ! regulation of protein activation cascade
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007597 ! blood coagulation, intrinsic pathway
relationship: regulates GO:0007597 ! blood coagulation, intrinsic pathway
created_by: midori
creation_date: 2010-11-23T11:45:40Z

[Term]
id: GO:2000267
name: negative regulation of blood coagulation, intrinsic pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation, intrinsic pathway." [GOC:mah]
is_a: GO:0030195 ! negative regulation of blood coagulation
is_a: GO:2000258 ! negative regulation of protein activation cascade
is_a: GO:2000266 ! regulation of blood coagulation, intrinsic pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007597 ! blood coagulation, intrinsic pathway
relationship: negatively_regulates GO:0007597 ! blood coagulation, intrinsic pathway
created_by: midori
creation_date: 2010-11-23T11:45:46Z

[Term]
id: GO:2000268
name: positive regulation of blood coagulation, intrinsic pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of blood coagulation, intrinsic pathway." [GOC:mah]
is_a: GO:0030194 ! positive regulation of blood coagulation
is_a: GO:2000259 ! positive regulation of protein activation cascade
is_a: GO:2000266 ! regulation of blood coagulation, intrinsic pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007597 ! blood coagulation, intrinsic pathway
relationship: positively_regulates GO:0007597 ! blood coagulation, intrinsic pathway
created_by: midori
creation_date: 2010-11-23T11:45:51Z

[Term]
id: GO:2000269
name: regulation of fibroblast apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fibroblast apoptotic process." [GOC:mtg_apoptosis, GOC:obol, GOC:yaf]
synonym: "regulation of fibroblast apoptosis" NARROW []
is_a: GO:0042981 ! regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044346 ! fibroblast apoptotic process
relationship: regulates GO:0044346 ! fibroblast apoptotic process
created_by: jane
creation_date: 2010-11-23T01:07:23Z

[Term]
id: GO:2000270
name: negative regulation of fibroblast apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast apoptotic process." [GOC:mtg_apoptosis, GOC:obol, GOC:yaf]
synonym: "negative regulation of fibroblast apoptosis" NARROW []
is_a: GO:0043066 ! negative regulation of apoptotic process
is_a: GO:2000269 ! regulation of fibroblast apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044346 ! fibroblast apoptotic process
relationship: negatively_regulates GO:0044346 ! fibroblast apoptotic process
created_by: jane
creation_date: 2010-11-23T01:07:27Z

[Term]
id: GO:2000271
name: positive regulation of fibroblast apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of fibroblast apoptotic process." [GOC:mtg_apoptosis, GOC:obol, GOC:yaf]
synonym: "positive regulation of fibroblast apoptosis" NARROW []
is_a: GO:0043065 ! positive regulation of apoptotic process
is_a: GO:2000269 ! regulation of fibroblast apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044346 ! fibroblast apoptotic process
relationship: positively_regulates GO:0044346 ! fibroblast apoptotic process
created_by: jane
creation_date: 2010-11-23T01:07:29Z

[Term]
id: GO:2000272
name: negative regulation of receptor activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of receptor activity." [GOC:obol]
is_a: GO:0010469 ! regulation of receptor activity
is_a: GO:0044092 ! negative regulation of molecular function
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004872 ! receptor activity
relationship: negatively_regulates GO:0004872 ! receptor activity
created_by: rfoulger
creation_date: 2010-12-02T09:28:47Z

[Term]
id: GO:2000273
name: positive regulation of receptor activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of receptor activity." [GOC:obol]
is_a: GO:0010469 ! regulation of receptor activity
is_a: GO:0044093 ! positive regulation of molecular function
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004872 ! receptor activity
relationship: positively_regulates GO:0004872 ! receptor activity
created_by: rfoulger
creation_date: 2010-12-02T09:28:50Z

[Term]
id: GO:2000274
name: regulation of epithelial cell migration, open tracheal system
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of epithelial cell migration, open tracheal system." [GOC:obol]
synonym: "regulation of tracheal cell migration" RELATED [GOC:obol]
synonym: "regulation of tracheal epithelial cell migration" RELATED [GOC:obol]
is_a: GO:0010632 ! regulation of epithelial cell migration
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007427 ! epithelial cell migration, open tracheal system
relationship: regulates GO:0007427 ! epithelial cell migration, open tracheal system
created_by: sart
creation_date: 2010-12-03T02:08:43Z

[Term]
id: GO:2000275
name: regulation of oxidative phosphorylation uncoupler activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of oxidative phosphorylation uncoupler activity." [GOC:mah]
synonym: "regulation of mitochondrial uncoupling protein activity" RELATED [GOC:obol]
synonym: "regulation of uncoupling protein activity" RELATED [GOC:obol]
is_a: GO:0010155 ! regulation of proton transport
is_a: GO:0022898 ! regulation of transmembrane transporter activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0017077 ! oxidative phosphorylation uncoupler activity
relationship: regulates GO:0017077 ! oxidative phosphorylation uncoupler activity
created_by: midori
creation_date: 2010-12-07T12:14:54Z

[Term]
id: GO:2000276
name: negative regulation of oxidative phosphorylation uncoupler activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of oxidative phosphorylation uncoupler activity." [GOC:mah]
synonym: "negative regulation of mitochondrial uncoupling protein activity" RELATED [GOC:obol]
synonym: "negative regulation of uncoupling protein activity" RELATED [GOC:obol]
is_a: GO:0032410 ! negative regulation of transporter activity
is_a: GO:0034763 ! negative regulation of transmembrane transport
is_a: GO:0043271 ! negative regulation of ion transport
is_a: GO:2000275 ! regulation of oxidative phosphorylation uncoupler activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0017077 ! oxidative phosphorylation uncoupler activity
relationship: negatively_regulates GO:0017077 ! oxidative phosphorylation uncoupler activity
created_by: midori
creation_date: 2010-12-07T12:14:59Z

[Term]
id: GO:2000277
name: positive regulation of oxidative phosphorylation uncoupler activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of oxidative phosphorylation uncoupler activity." [GOC:mah]
synonym: "positive regulation of mitochondrial uncoupling protein activity" RELATED [GOC:obol]
synonym: "positive regulation of uncoupling protein activity" RELATED [GOC:obol]
is_a: GO:0032411 ! positive regulation of transporter activity
is_a: GO:0034764 ! positive regulation of transmembrane transport
is_a: GO:0043270 ! positive regulation of ion transport
is_a: GO:2000275 ! regulation of oxidative phosphorylation uncoupler activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0017077 ! oxidative phosphorylation uncoupler activity
relationship: positively_regulates GO:0017077 ! oxidative phosphorylation uncoupler activity
created_by: midori
creation_date: 2010-12-07T12:15:02Z

[Term]
id: GO:2000278
name: regulation of DNA biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA biosynthetic process." [GOC:obol]
synonym: "regulation of DNA anabolism" EXACT [GOC:obol]
synonym: "regulation of DNA biosynthesis" EXACT [GOC:obol]
synonym: "regulation of DNA formation" EXACT [GOC:obol]
synonym: "regulation of DNA synthesis" EXACT [GOC:obol]
is_a: GO:0051052 ! regulation of DNA metabolic process
is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071897 ! DNA biosynthetic process
relationship: regulates GO:0071897 ! DNA biosynthetic process
created_by: yaf
creation_date: 2010-12-08T04:48:15Z

[Term]
id: GO:2000279
name: negative regulation of DNA biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA biosynthetic process." [GOC:obol]
synonym: "negative regulation of DNA anabolism" EXACT [GOC:obol]
synonym: "negative regulation of DNA biosynthesis" EXACT [GOC:obol]
synonym: "negative regulation of DNA formation" EXACT [GOC:obol]
synonym: "negative regulation of DNA synthesis" EXACT [GOC:obol]
is_a: GO:0051053 ! negative regulation of DNA metabolic process
is_a: GO:2000113 ! negative regulation of cellular macromolecule biosynthetic process
is_a: GO:2000278 ! regulation of DNA biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071897 ! DNA biosynthetic process
relationship: negatively_regulates GO:0071897 ! DNA biosynthetic process
created_by: yaf
creation_date: 2010-12-08T04:48:20Z

[Term]
id: GO:2000280
name: regulation of root development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of root development." [GOC:obol]
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048364 ! root development
relationship: regulates GO:0048364 ! root development
created_by: dhl
creation_date: 2010-12-08T09:30:21Z

[Term]
id: GO:2000281
name: regulation of histone H3-T3 phosphorylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of histone H3-T3 phosphorylation." [GOC:obol]
is_a: GO:0010799 ! regulation of peptidyl-threonine phosphorylation
is_a: GO:0033127 ! regulation of histone phosphorylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072355 ! histone H3-T3 phosphorylation
relationship: regulates GO:0072355 ! histone H3-T3 phosphorylation
created_by: vw
creation_date: 2010-12-10T11:48:31Z

[Term]
id: GO:2000282
name: regulation of cellular amino acid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular amino acid biosynthetic process." [GOC:obol]
synonym: "regulation of amino acid biosynthetic process" EXACT [GOC:obol]
synonym: "regulation of cellular amino acid anabolism" EXACT [GOC:obol]
synonym: "regulation of cellular amino acid biosynthesis" EXACT [GOC:obol]
synonym: "regulation of cellular amino acid formation" EXACT [GOC:obol]
synonym: "regulation of cellular amino acid synthesis" EXACT [GOC:obol]
is_a: GO:0006521 ! regulation of cellular amino acid metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008652 ! cellular amino acid biosynthetic process
relationship: regulates GO:0008652 ! cellular amino acid biosynthetic process
created_by: vw
creation_date: 2010-12-10T11:54:19Z

[Term]
id: GO:2000283
name: negative regulation of cellular amino acid biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular amino acid biosynthetic process." [GOC:obol]
synonym: "negative regulation of amino acid biosynthetic process" EXACT [GOC:obol]
synonym: "negative regulation of cellular amino acid anabolism" EXACT [GOC:obol]
synonym: "negative regulation of cellular amino acid biosynthesis" EXACT [GOC:obol]
synonym: "negative regulation of cellular amino acid formation" EXACT [GOC:obol]
synonym: "negative regulation of cellular amino acid synthesis" EXACT [GOC:obol]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0045763 ! negative regulation of cellular amino acid metabolic process
is_a: GO:2000282 ! regulation of cellular amino acid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008652 ! cellular amino acid biosynthetic process
relationship: negatively_regulates GO:0008652 ! cellular amino acid biosynthetic process
created_by: vw
creation_date: 2010-12-10T11:54:23Z

[Term]
id: GO:2000284
name: positive regulation of cellular amino acid biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellular amino acid biosynthetic process." [GOC:obol]
synonym: "positive regulation of amino acid biosynthetic process" EXACT [GOC:obol]
synonym: "positive regulation of cellular amino acid anabolism" EXACT [GOC:obol]
synonym: "positive regulation of cellular amino acid biosynthesis" EXACT [GOC:obol]
synonym: "positive regulation of cellular amino acid formation" EXACT [GOC:obol]
synonym: "positive regulation of cellular amino acid synthesis" EXACT [GOC:obol]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0045764 ! positive regulation of cellular amino acid metabolic process
is_a: GO:2000282 ! regulation of cellular amino acid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008652 ! cellular amino acid biosynthetic process
relationship: positively_regulates GO:0008652 ! cellular amino acid biosynthetic process
created_by: vw
creation_date: 2010-12-10T11:54:27Z

[Term]
id: GO:2000285
name: obsolete negative regulation of regulation of excitatory postsynaptic membrane potential
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of regulation of excitatory postsynaptic membrane potential." [GOC:BHF]
comment: This term was made obsolete because it makes no sense and was added in error.
synonym: "negative regulation of EPSP" RELATED [GOC:obol]
synonym: "negative regulation of regulation of excitatory postsynaptic membrane potential" EXACT []
is_obsolete: true
replaced_by: GO:0090394
created_by: vk
creation_date: 2010-12-12T03:27:21Z

[Term]
id: GO:2000286
name: receptor internalization involved in canonical Wnt signaling pathway
namespace: biological_process
def: "A receptor internalization process that contributes to canonical Wnt signaling pathway." [GOC:BHF, GOC:mah, PMID:16890161]
synonym: "receptor internalization involved in canonical Wnt receptor signaling pathway" EXACT []
synonym: "receptor internalization involved in canonical Wnt receptor signalling pathway" EXACT [GOC:obol]
synonym: "receptor internalization involved in canonical Wnt-activated signaling pathway" EXACT [GOC:signaling]
synonym: "receptor internalization involved in frizzled-1 receptor signaling pathway" RELATED [GOC:obol]
synonym: "receptor internalization involved in Wnt receptor signaling pathway through beta-catenin" EXACT [GOC:obol]
synonym: "receptor internalization involved in Wnt receptor signaling pathway via beta-catenin" EXACT [GOC:obol]
synonym: "receptor internalization involved in Wnt receptor signalling pathway through beta-catenin" EXACT [GOC:obol]
is_a: GO:0031623 ! receptor internalization
intersection_of: GO:0031623 ! receptor internalization
intersection_of: part_of GO:0060070 ! canonical Wnt signaling pathway
relationship: part_of GO:0060070 ! canonical Wnt signaling pathway
created_by: midori
creation_date: 2010-12-15T12:25:40Z

[Term]
id: GO:2000287
name: positive regulation of myotome development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of myotome development." [GOC:BHF]
is_a: GO:0040019 ! positive regulation of embryonic development
is_a: GO:2000290 ! regulation of myotome development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061055 ! myotome development
relationship: positively_regulates GO:0061055 ! myotome development
created_by: rl
creation_date: 2010-12-16T05:17:15Z

[Term]
id: GO:2000288
name: positive regulation of myoblast proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of myoblast proliferation." [GOC:BHF]
is_a: GO:0008284 ! positive regulation of cell proliferation
is_a: GO:2000291 ! regulation of myoblast proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051450 ! myoblast proliferation
relationship: positively_regulates GO:0051450 ! myoblast proliferation
created_by: rl
creation_date: 2010-12-16T05:20:52Z

[Term]
id: GO:2000289
name: regulation of photoreceptor cell axon guidance
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of photoreceptor cell axon guidance." [GOC:mah]
synonym: "regulation of photoreceptor cell axon pathfinding" EXACT [GOC:obol]
is_a: GO:1902667 ! regulation of axon guidance
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072499 ! photoreceptor cell axon guidance
relationship: regulates GO:0072499 ! photoreceptor cell axon guidance
created_by: midori
creation_date: 2010-12-17T10:04:35Z

[Term]
id: GO:2000290
name: regulation of myotome development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of myotome development." [GOC:mah]
is_a: GO:0045995 ! regulation of embryonic development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061055 ! myotome development
relationship: regulates GO:0061055 ! myotome development
created_by: midori
creation_date: 2010-12-20T10:22:05Z

[Term]
id: GO:2000291
name: regulation of myoblast proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of myoblast proliferation." [GOC:mah]
is_a: GO:0042127 ! regulation of cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051450 ! myoblast proliferation
relationship: regulates GO:0051450 ! myoblast proliferation
created_by: midori
creation_date: 2010-12-20T10:34:26Z

[Term]
id: GO:2000292
name: regulation of defecation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of defecation." [GOC:obol]
is_a: GO:0044062 ! regulation of excretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030421 ! defecation
relationship: regulates GO:0030421 ! defecation
created_by: rfoulger
creation_date: 2010-12-21T09:23:08Z

[Term]
id: GO:2000293
name: negative regulation of defecation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of defecation." [GOC:obol]
is_a: GO:0051048 ! negative regulation of secretion
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000292 ! regulation of defecation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030421 ! defecation
relationship: negatively_regulates GO:0030421 ! defecation
created_by: rfoulger
creation_date: 2010-12-21T09:23:13Z

[Term]
id: GO:2000294
name: positive regulation of defecation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of defecation." [GOC:obol]
is_a: GO:0051047 ! positive regulation of secretion
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000292 ! regulation of defecation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030421 ! defecation
relationship: positively_regulates GO:0030421 ! defecation
created_by: rfoulger
creation_date: 2010-12-21T09:23:16Z

[Term]
id: GO:2000295
name: regulation of hydrogen peroxide catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hydrogen peroxide catabolic process." [GOC:BHF]
synonym: "regulation of detoxification of H2O2" RELATED [GOC:obol]
synonym: "regulation of detoxification of hydrogen peroxide" RELATED [GOC:obol]
synonym: "regulation of H2O2 catabolic process" EXACT [GOC:obol]
synonym: "regulation of H2O2 scavenging" RELATED [GOC:obol]
synonym: "regulation of hydrogen peroxide breakdown" EXACT [GOC:obol]
synonym: "regulation of hydrogen peroxide catabolism" EXACT [GOC:obol]
synonym: "regulation of hydrogen peroxide degradation" EXACT [GOC:obol]
synonym: "regulation of hydrogen peroxide removal" RELATED [GOC:obol]
synonym: "regulation of hydrogen peroxide scavenging" RELATED [GOC:obol]
is_a: GO:0010310 ! regulation of hydrogen peroxide metabolic process
is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:1900407 ! regulation of cellular response to oxidative stress
is_a: GO:1901031 ! regulation of response to reactive oxygen species
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042744 ! hydrogen peroxide catabolic process
relationship: regulates GO:0042744 ! hydrogen peroxide catabolic process
created_by: rl
creation_date: 2010-12-21T03:30:51Z

[Term]
id: GO:2000296
name: negative regulation of hydrogen peroxide catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide catabolic process." [GOC:BHF]
synonym: "negative regulation of detoxification of H2O2" RELATED [GOC:obol]
synonym: "negative regulation of detoxification of hydrogen peroxide" RELATED [GOC:obol]
synonym: "negative regulation of H2O2 catabolic process" EXACT [GOC:obol]
synonym: "negative regulation of H2O2 scavenging" RELATED [GOC:obol]
synonym: "negative regulation of hydrogen peroxide breakdown" EXACT [GOC:obol]
synonym: "negative regulation of hydrogen peroxide catabolism" EXACT [GOC:obol]
synonym: "negative regulation of hydrogen peroxide degradation" EXACT [GOC:obol]
synonym: "negative regulation of hydrogen peroxide removal" RELATED [GOC:obol]
synonym: "negative regulation of hydrogen peroxide scavenging" RELATED [GOC:obol]
is_a: GO:0010727 ! negative regulation of hydrogen peroxide metabolic process
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:1900408 ! negative regulation of cellular response to oxidative stress
is_a: GO:1901032 ! negative regulation of response to reactive oxygen species
is_a: GO:2000295 ! regulation of hydrogen peroxide catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042744 ! hydrogen peroxide catabolic process
relationship: negatively_regulates GO:0042744 ! hydrogen peroxide catabolic process
created_by: rl
creation_date: 2010-12-21T03:30:55Z

[Term]
id: GO:2000297
name: negative regulation of synapse maturation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of synapse maturation." [GOC:mah]
synonym: "negative regulation of synaptic maturation" EXACT [GOC:obol]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:0051961 ! negative regulation of nervous system development
is_a: GO:0090128 ! regulation of synapse maturation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060074 ! synapse maturation
relationship: negatively_regulates GO:0060074 ! synapse maturation
created_by: midori
creation_date: 2010-12-23T11:37:31Z

[Term]
id: GO:2000298
name: regulation of Rho-dependent protein serine/threonine kinase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Rho-dependent protein serine/threonine kinase activity." [GOC:mah]
synonym: "regulation of Rho-associated protein kinase activity" EXACT [GOC:obol]
synonym: "regulation of ROCK kinase activity" EXACT [GOC:obol]
is_a: GO:0071900 ! regulation of protein serine/threonine kinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072518 ! Rho-dependent protein serine/threonine kinase activity
relationship: regulates GO:0072518 ! Rho-dependent protein serine/threonine kinase activity
created_by: midori
creation_date: 2010-12-23T11:44:50Z

[Term]
id: GO:2000299
name: negative regulation of Rho-dependent protein serine/threonine kinase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of Rho-dependent protein serine/threonine kinase activity." [GOC:mah]
synonym: "negative regulation of Rho-associated protein kinase activity" EXACT [GOC:obol]
synonym: "negative regulation of ROCK kinase activity" EXACT [GOC:obol]
is_a: GO:0071901 ! negative regulation of protein serine/threonine kinase activity
is_a: GO:2000298 ! regulation of Rho-dependent protein serine/threonine kinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072518 ! Rho-dependent protein serine/threonine kinase activity
relationship: negatively_regulates GO:0072518 ! Rho-dependent protein serine/threonine kinase activity
created_by: midori
creation_date: 2010-12-23T11:44:57Z

[Term]
id: GO:2000300
name: regulation of synaptic vesicle exocytosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis." [GOC:obol]
is_a: GO:0017158 ! regulation of calcium ion-dependent exocytosis
is_a: GO:0046928 ! regulation of neurotransmitter secretion
is_a: GO:1902803 ! regulation of synaptic vesicle transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016079 ! synaptic vesicle exocytosis
relationship: regulates GO:0016079 ! synaptic vesicle exocytosis
created_by: dph
creation_date: 2011-01-03T08:20:40Z

[Term]
id: GO:2000301
name: negative regulation of synaptic vesicle exocytosis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle exocytosis." [GOC:obol]
is_a: GO:0045955 ! negative regulation of calcium ion-dependent exocytosis
is_a: GO:0046929 ! negative regulation of neurotransmitter secretion
is_a: GO:1902804 ! negative regulation of synaptic vesicle transport
is_a: GO:2000300 ! regulation of synaptic vesicle exocytosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016079 ! synaptic vesicle exocytosis
relationship: negatively_regulates GO:0016079 ! synaptic vesicle exocytosis
created_by: dph
creation_date: 2011-01-03T08:21:00Z

[Term]
id: GO:2000302
name: positive regulation of synaptic vesicle exocytosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of synaptic vesicle exocytosis." [GOC:obol]
is_a: GO:0001956 ! positive regulation of neurotransmitter secretion
is_a: GO:0045956 ! positive regulation of calcium ion-dependent exocytosis
is_a: GO:1902805 ! positive regulation of synaptic vesicle transport
is_a: GO:2000300 ! regulation of synaptic vesicle exocytosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016079 ! synaptic vesicle exocytosis
relationship: positively_regulates GO:0016079 ! synaptic vesicle exocytosis
created_by: dph
creation_date: 2011-01-03T08:21:14Z

[Term]
id: GO:2000303
name: regulation of ceramide biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a ceramide biosynthetic process." [GOC:dph]
synonym: "regulation of ceramide anabolism" EXACT [GOC:obol]
synonym: "regulation of ceramide biosynthesis" EXACT [GOC:obol]
synonym: "regulation of ceramide formation" EXACT [GOC:obol]
synonym: "regulation of ceramide synthesis" EXACT [GOC:obol]
is_a: GO:0034248 ! regulation of cellular amide metabolic process
is_a: GO:0090153 ! regulation of sphingolipid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0046513 ! ceramide biosynthetic process
relationship: regulates GO:0046513 ! ceramide biosynthetic process
created_by: dph
creation_date: 2011-01-04T02:37:12Z

[Term]
id: GO:2000304
name: positive regulation of ceramide biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ceramide biosynthetic process." [GOC:dph]
synonym: "positive regulation of ceramide anabolism" EXACT [GOC:obol]
synonym: "positive regulation of ceramide biosynthesis" EXACT [GOC:obol]
synonym: "positive regulation of ceramide formation" EXACT [GOC:obol]
synonym: "positive regulation of ceramide synthesis" EXACT [GOC:obol]
is_a: GO:0034250 ! positive regulation of cellular amide metabolic process
is_a: GO:0090154 ! positive regulation of sphingolipid biosynthetic process
is_a: GO:2000303 ! regulation of ceramide biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0046513 ! ceramide biosynthetic process
relationship: positively_regulates GO:0046513 ! ceramide biosynthetic process
created_by: dph
creation_date: 2011-01-04T02:37:32Z

[Term]
id: GO:2000305
name: semaphorin-plexin signaling pathway involved in regulation of photoreceptor cell axon guidance
namespace: biological_process
def: "Any semaphorin-plexin signaling pathway that is involved in regulation of photoreceptor cell axon guidance." [GOC:obol]
synonym: "semaphorin-plexin signaling pathway of regulation of photoreceptor cell axon guidance" EXACT [GOC:obol]
synonym: "semaphorin-plexin signaling pathway of regulation of photoreceptor cell axon pathfinding" EXACT [GOC:obol]
synonym: "semaphorin-plexin signalling pathway of regulation of photoreceptor cell axon guidance" EXACT [GOC:obol]
synonym: "semaphorin-plexin signalling pathway of regulation of photoreceptor cell axon pathfinding" EXACT [GOC:obol]
is_a: GO:0071526 ! semaphorin-plexin signaling pathway
intersection_of: GO:0071526 ! semaphorin-plexin signaling pathway
intersection_of: part_of GO:2000289 ! regulation of photoreceptor cell axon guidance
relationship: part_of GO:2000289 ! regulation of photoreceptor cell axon guidance
created_by: sart
creation_date: 2011-01-07T01:42:34Z

[Term]
id: GO:2000306
name: positive regulation of photomorphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of photomorphogenesis." [GOC:obol]
synonym: "positive regulation of plant development in response to light" EXACT [GOC:obol]
is_a: GO:0010099 ! regulation of photomorphogenesis
is_a: GO:0048582 ! positive regulation of post-embryonic development
is_a: GO:0048584 ! positive regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009640 ! photomorphogenesis
relationship: positively_regulates GO:0009640 ! photomorphogenesis
created_by: dhl
creation_date: 2011-01-12T07:09:02Z

[Term]
id: GO:2000307
name: regulation of tumor necrosis factor (ligand) superfamily member 11 production
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tumor necrosis factor (ligand) superfamily member 11 production." [GOC:BHF, GOC:mah]
synonym: "regulation of RANKL production" EXACT [GOC:obol]
synonym: "regulation of TNFSF11 production" EXACT [GOC:obol]
is_a: GO:1903555 ! regulation of tumor necrosis factor superfamily cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072535 ! tumor necrosis factor (ligand) superfamily member 11 production
relationship: regulates GO:0072535 ! tumor necrosis factor (ligand) superfamily member 11 production
created_by: midori
creation_date: 2011-01-17T10:44:00Z

[Term]
id: GO:2000308
name: negative regulation of tumor necrosis factor (ligand) superfamily member 11 production
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tumor necrosis factor (ligand) superfamily member 11 production." [GOC:BHF, GOC:mah]
synonym: "negative regulation of RANKL production" EXACT [GOC:obol]
synonym: "negative regulation of TNFSF11 production" EXACT [GOC:obol]
is_a: GO:1903556 ! negative regulation of tumor necrosis factor superfamily cytokine production
is_a: GO:2000307 ! regulation of tumor necrosis factor (ligand) superfamily member 11 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072535 ! tumor necrosis factor (ligand) superfamily member 11 production
relationship: negatively_regulates GO:0072535 ! tumor necrosis factor (ligand) superfamily member 11 production
created_by: midori
creation_date: 2011-01-17T10:44:33Z

[Term]
id: GO:2000309
name: positive regulation of tumor necrosis factor (ligand) superfamily member 11 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tumor necrosis factor (ligand) superfamily member 11 production." [GOC:BHF, GOC:mah]
synonym: "positive regulation of RANKL production" EXACT [GOC:obol]
synonym: "positive regulation of TNFSF11 production" EXACT [GOC:obol]
is_a: GO:1903557 ! positive regulation of tumor necrosis factor superfamily cytokine production
is_a: GO:2000307 ! regulation of tumor necrosis factor (ligand) superfamily member 11 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072535 ! tumor necrosis factor (ligand) superfamily member 11 production
relationship: positively_regulates GO:0072535 ! tumor necrosis factor (ligand) superfamily member 11 production
created_by: midori
creation_date: 2011-01-17T10:44:54Z

[Term]
id: GO:2000310
name: regulation of N-methyl-D-aspartate selective glutamate receptor activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of N-methyl-D-aspartate selective glutamate receptor activity." [GOC:BHF]
synonym: "regulation of NMDA receptor" EXACT [GOC:obol]
is_a: GO:0032412 ! regulation of ion transmembrane transporter activity
is_a: GO:0099601 ! regulation of neurotransmitter receptor activity
is_a: GO:1900449 ! regulation of glutamate receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004972 ! NMDA glutamate receptor activity
relationship: regulates GO:0004972 ! NMDA glutamate receptor activity
created_by: rfoulger
creation_date: 2011-01-18T10:06:37Z

[Term]
id: GO:2000311
name: regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity." [GOC:BHF]
synonym: "regulation of AMPA receptor activity" EXACT [GOC:obol]
is_a: GO:0032412 ! regulation of ion transmembrane transporter activity
is_a: GO:0099601 ! regulation of neurotransmitter receptor activity
is_a: GO:1900449 ! regulation of glutamate receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004971 ! AMPA glutamate receptor activity
relationship: regulates GO:0004971 ! AMPA glutamate receptor activity
created_by: rfoulger
creation_date: 2011-01-18T10:10:28Z

[Term]
id: GO:2000312
name: regulation of kainate selective glutamate receptor activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of kainate selective glutamate receptor activity." [GOC:BHF]
is_a: GO:0032412 ! regulation of ion transmembrane transporter activity
is_a: GO:0099601 ! regulation of neurotransmitter receptor activity
is_a: GO:1900449 ! regulation of glutamate receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0015277 ! kainate selective glutamate receptor activity
relationship: regulates GO:0015277 ! kainate selective glutamate receptor activity
created_by: rfoulger
creation_date: 2011-01-18T10:14:16Z

[Term]
id: GO:2000313
name: regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation." [GOC:BHF]
synonym: "regulation of fibroblast growth factor receptor signalling pathway involved in neural plate anterior/posterior pattern formation" EXACT [GOC:obol]
is_a: GO:0040036 ! regulation of fibroblast growth factor receptor signaling pathway
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060825 ! fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation
relationship: regulates GO:0060825 ! fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation
created_by: vk
creation_date: 2011-01-18T10:26:22Z

[Term]
id: GO:2000314
name: negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation." [GOC:BHF]
synonym: "negative regulation of fibroblast growth factor receptor signalling pathway involved in neural plate anterior/posterior pattern formation" EXACT [GOC:obol]
is_a: GO:0040037 ! negative regulation of fibroblast growth factor receptor signaling pathway
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000313 ! regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060825 ! fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation
relationship: negatively_regulates GO:0060825 ! fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation
created_by: vk
creation_date: 2011-01-18T10:26:56Z

[Term]
id: GO:2000315
name: positive regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation." [GOC:BHF]
synonym: "positive regulation of fibroblast growth factor receptor signalling pathway involved in neural plate anterior/posterior pattern formation" EXACT [GOC:obol]
is_a: GO:0045743 ! positive regulation of fibroblast growth factor receptor signaling pathway
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000313 ! regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060825 ! fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation
relationship: positively_regulates GO:0060825 ! fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation
created_by: vk
creation_date: 2011-01-18T10:27:19Z

[Term]
id: GO:2000316
name: regulation of T-helper 17 type immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of T-helper 17 type immune response." [GOC:BHF, GOC:mah]
synonym: "regulation of Th17 immune response" EXACT [GOC:obol]
is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072538 ! T-helper 17 type immune response
relationship: regulates GO:0072538 ! T-helper 17 type immune response
created_by: midori
creation_date: 2011-01-18T01:32:26Z

[Term]
id: GO:2000317
name: negative regulation of T-helper 17 type immune response
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 type immune response." [GOC:BHF, GOC:mah]
synonym: "negative regulation of Th17 immune response" EXACT [GOC:obol]
is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
is_a: GO:2000316 ! regulation of T-helper 17 type immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072538 ! T-helper 17 type immune response
relationship: negatively_regulates GO:0072538 ! T-helper 17 type immune response
created_by: midori
creation_date: 2011-01-18T01:33:00Z

[Term]
id: GO:2000318
name: positive regulation of T-helper 17 type immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T-helper 17 type immune response." [GOC:BHF, GOC:mah]
synonym: "positive regulation of Th17 immune response" EXACT [GOC:obol]
is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
is_a: GO:2000316 ! regulation of T-helper 17 type immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072538 ! T-helper 17 type immune response
relationship: positively_regulates GO:0072538 ! T-helper 17 type immune response
created_by: midori
creation_date: 2011-01-18T01:33:24Z

[Term]
id: GO:2000319
name: regulation of T-helper 17 cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of T-helper 17 cell differentiation." [GOC:BHF, GOC:mah]
synonym: "regulation of T-helper 17 cell development" RELATED [GOC:obol]
is_a: GO:0045622 ! regulation of T-helper cell differentiation
is_a: GO:2000316 ! regulation of T-helper 17 type immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072539 ! T-helper 17 cell differentiation
relationship: regulates GO:0072539 ! T-helper 17 cell differentiation
created_by: midori
creation_date: 2011-01-18T01:43:48Z

[Term]
id: GO:2000320
name: negative regulation of T-helper 17 cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 cell differentiation." [GOC:BHF, GOC:mah]
synonym: "negative regulation of T-helper 17 cell development" RELATED [GOC:obol]
is_a: GO:0045623 ! negative regulation of T-helper cell differentiation
is_a: GO:2000317 ! negative regulation of T-helper 17 type immune response
is_a: GO:2000319 ! regulation of T-helper 17 cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072539 ! T-helper 17 cell differentiation
relationship: negatively_regulates GO:0072539 ! T-helper 17 cell differentiation
created_by: midori
creation_date: 2011-01-18T01:44:31Z

[Term]
id: GO:2000321
name: positive regulation of T-helper 17 cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T-helper 17 cell differentiation." [GOC:BHF, GOC:mah]
synonym: "positive regulation of T-helper 17 cell development" RELATED [GOC:obol]
is_a: GO:0045624 ! positive regulation of T-helper cell differentiation
is_a: GO:2000318 ! positive regulation of T-helper 17 type immune response
is_a: GO:2000319 ! regulation of T-helper 17 cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072539 ! T-helper 17 cell differentiation
relationship: positively_regulates GO:0072539 ! T-helper 17 cell differentiation
created_by: midori
creation_date: 2011-01-18T01:45:08Z

[Term]
id: GO:2000322
name: regulation of glucocorticoid receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glucocorticoid receptor signaling pathway." [GOC:BHF]
synonym: "regulation of glucocorticoid receptor signalling pathway" EXACT [GOC:obol]
is_a: GO:0033143 ! regulation of intracellular steroid hormone receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042921 ! glucocorticoid receptor signaling pathway
relationship: regulates GO:0042921 ! glucocorticoid receptor signaling pathway
created_by: vk
creation_date: 2011-01-18T04:38:10Z

[Term]
id: GO:2000323
name: negative regulation of glucocorticoid receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glucocorticoid receptor signaling pathway." [GOC:BHF]
synonym: "negative regulation of glucocorticoid receptor signalling pathway" EXACT [GOC:obol]
is_a: GO:0033144 ! negative regulation of intracellular steroid hormone receptor signaling pathway
is_a: GO:2000322 ! regulation of glucocorticoid receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042921 ! glucocorticoid receptor signaling pathway
relationship: negatively_regulates GO:0042921 ! glucocorticoid receptor signaling pathway
created_by: vk
creation_date: 2011-01-18T04:38:43Z

[Term]
id: GO:2000324
name: positive regulation of glucocorticoid receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glucocorticoid receptor signaling pathway." [GOC:BHF]
synonym: "positive regulation of glucocorticoid receptor signalling pathway" EXACT [GOC:obol]
is_a: GO:0033145 ! positive regulation of intracellular steroid hormone receptor signaling pathway
is_a: GO:2000322 ! regulation of glucocorticoid receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042921 ! glucocorticoid receptor signaling pathway
relationship: positively_regulates GO:0042921 ! glucocorticoid receptor signaling pathway
created_by: vk
creation_date: 2011-01-18T04:39:05Z

[Term]
id: GO:2000325
name: regulation of ligand-dependent nuclear receptor transcription coactivator activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ligand-dependent nuclear receptor transcription coactivator activity." [GOC:BHF]
synonym: "regulation of ligand-dependent nuclear receptor transcription co-activator activity" EXACT [GOC:obol]
is_a: GO:0065009 ! regulation of molecular function
is_a: GO:1903506 ! regulation of nucleic acid-templated transcription
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030374 ! ligand-dependent nuclear receptor transcription coactivator activity
relationship: regulates GO:0030374 ! ligand-dependent nuclear receptor transcription coactivator activity
created_by: vk
creation_date: 2011-01-18T06:29:32Z

[Term]
id: GO:2000326
name: negative regulation of ligand-dependent nuclear receptor transcription coactivator activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ligand-dependent nuclear receptor transcription coactivator activity." [GOC:BHF]
synonym: "negative regulation of ligand-dependent nuclear receptor transcription co-activator activity" EXACT [GOC:obol]
is_a: GO:0044092 ! negative regulation of molecular function
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:2000325 ! regulation of ligand-dependent nuclear receptor transcription coactivator activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030374 ! ligand-dependent nuclear receptor transcription coactivator activity
relationship: negatively_regulates GO:0030374 ! ligand-dependent nuclear receptor transcription coactivator activity
created_by: vk
creation_date: 2011-01-18T06:30:03Z

[Term]
id: GO:2000327
name: positive regulation of ligand-dependent nuclear receptor transcription coactivator activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ligand-dependent nuclear receptor transcription coactivator activity." [GOC:BHF]
synonym: "positive regulation of ligand-dependent nuclear receptor transcription co-activator activity" EXACT [GOC:obol]
is_a: GO:0044093 ! positive regulation of molecular function
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:2000325 ! regulation of ligand-dependent nuclear receptor transcription coactivator activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030374 ! ligand-dependent nuclear receptor transcription coactivator activity
relationship: positively_regulates GO:0030374 ! ligand-dependent nuclear receptor transcription coactivator activity
created_by: vk
creation_date: 2011-01-18T06:30:23Z

[Term]
id: GO:2000328
name: regulation of T-helper 17 cell lineage commitment
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of T-helper 17 cell lineage commitment." [GOC:BHF, GOC:mah]
synonym: "regulation of T-helper 17 cell fate commitment" EXACT [GOC:obol]
synonym: "regulation of Th17 cell lineage commitment" EXACT [GOC:obol]
synonym: "regulation of Th17 fate commitment" EXACT [GOC:obol]
is_a: GO:0010453 ! regulation of cell fate commitment
is_a: GO:2000319 ! regulation of T-helper 17 cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072540 ! T-helper 17 cell lineage commitment
relationship: regulates GO:0072540 ! T-helper 17 cell lineage commitment
created_by: midori
creation_date: 2011-01-19T09:31:19Z

[Term]
id: GO:2000329
name: negative regulation of T-helper 17 cell lineage commitment
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 cell lineage commitment." [GOC:BHF, GOC:mah]
synonym: "negative regulation of T-helper 17 cell fate commitment" EXACT [GOC:obol]
synonym: "negative regulation of Th17 cell lineage commitment" EXACT [GOC:obol]
synonym: "negative regulation of Th17 fate commitment" EXACT [GOC:obol]
is_a: GO:0010454 ! negative regulation of cell fate commitment
is_a: GO:2000320 ! negative regulation of T-helper 17 cell differentiation
is_a: GO:2000328 ! regulation of T-helper 17 cell lineage commitment
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072540 ! T-helper 17 cell lineage commitment
relationship: negatively_regulates GO:0072540 ! T-helper 17 cell lineage commitment
created_by: midori
creation_date: 2011-01-19T09:31:53Z

[Term]
id: GO:2000330
name: positive regulation of T-helper 17 cell lineage commitment
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T-helper 17 cell lineage commitment." [GOC:BHF, GOC:mah]
synonym: "positive regulation of T-helper 17 cell fate commitment" EXACT [GOC:obol]
synonym: "positive regulation of Th17 cell lineage commitment" EXACT [GOC:obol]
synonym: "positive regulation of Th17 fate commitment" EXACT [GOC:obol]
is_a: GO:0010455 ! positive regulation of cell fate commitment
is_a: GO:2000321 ! positive regulation of T-helper 17 cell differentiation
is_a: GO:2000328 ! regulation of T-helper 17 cell lineage commitment
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072540 ! T-helper 17 cell lineage commitment
relationship: positively_regulates GO:0072540 ! T-helper 17 cell lineage commitment
created_by: midori
creation_date: 2011-01-19T09:32:16Z

[Term]
id: GO:2000331
name: regulation of terminal button organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of terminal button organization." [GOC:BHF, GOC:mah]
synonym: "regulation of bouton organization" EXACT [GOC:obol]
synonym: "regulation of presynaptic bouton organization" EXACT [GOC:obol]
synonym: "regulation of synaptic bouton organization" EXACT [GOC:obol]
synonym: "regulation of terminal bouton organization" EXACT [GOC:obol]
synonym: "regulation of terminal button organisation" EXACT [GOC:obol]
is_a: GO:0050807 ! regulation of synapse organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072553 ! terminal button organization
relationship: regulates GO:0072553 ! terminal button organization
created_by: midori
creation_date: 2011-01-28T11:29:08Z

[Term]
id: GO:2000332
name: regulation of blood microparticle formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of blood microparticle formation." [GOC:BHF, GOC:mah]
synonym: "regulation of microparticle generation" EXACT [GOC:obol]
synonym: "regulation of microparticle release" EXACT [GOC:obol]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072564 ! blood microparticle formation
relationship: regulates GO:0072564 ! blood microparticle formation
created_by: midori
creation_date: 2011-01-31T11:18:11Z

[Term]
id: GO:2000333
name: negative regulation of blood microparticle formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of blood microparticle formation." [GOC:BHF, GOC:mah]
synonym: "negative regulation of microparticle generation" EXACT [GOC:obol]
synonym: "negative regulation of microparticle release" EXACT [GOC:obol]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:2000332 ! regulation of blood microparticle formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072564 ! blood microparticle formation
relationship: negatively_regulates GO:0072564 ! blood microparticle formation
created_by: midori
creation_date: 2011-01-31T11:18:18Z

[Term]
id: GO:2000334
name: positive regulation of blood microparticle formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of blood microparticle formation." [GOC:BHF, GOC:mah]
synonym: "positive regulation of microparticle generation" EXACT [GOC:obol]
synonym: "positive regulation of microparticle release" EXACT [GOC:obol]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:2000332 ! regulation of blood microparticle formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072564 ! blood microparticle formation
relationship: positively_regulates GO:0072564 ! blood microparticle formation
created_by: midori
creation_date: 2011-01-31T11:18:23Z

[Term]
id: GO:2000335
name: regulation of endothelial microparticle formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endothelial microparticle formation." [GOC:BHF, GOC:mah]
synonym: "regulation of endothelial microparticle generation" EXACT [GOC:obol]
synonym: "regulation of endothelial microparticle release" EXACT [GOC:obol]
is_a: GO:2000332 ! regulation of blood microparticle formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072565 ! endothelial microparticle formation
relationship: regulates GO:0072565 ! endothelial microparticle formation
created_by: midori
creation_date: 2011-01-31T11:20:26Z

[Term]
id: GO:2000336
name: negative regulation of endothelial microparticle formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial microparticle formation." [GOC:BHF, GOC:mah]
synonym: "negative regulation of endothelial microparticle generation" EXACT [GOC:obol]
synonym: "negative regulation of endothelial microparticle release" EXACT [GOC:obol]
is_a: GO:2000333 ! negative regulation of blood microparticle formation
is_a: GO:2000335 ! regulation of endothelial microparticle formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072565 ! endothelial microparticle formation
relationship: negatively_regulates GO:0072565 ! endothelial microparticle formation
created_by: midori
creation_date: 2011-01-31T11:20:33Z

[Term]
id: GO:2000337
name: positive regulation of endothelial microparticle formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endothelial microparticle formation." [GOC:BHF, GOC:mah]
synonym: "positive regulation of endothelial microparticle generation" EXACT [GOC:obol]
synonym: "positive regulation of endothelial microparticle release" EXACT [GOC:obol]
is_a: GO:2000334 ! positive regulation of blood microparticle formation
is_a: GO:2000335 ! regulation of endothelial microparticle formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072565 ! endothelial microparticle formation
relationship: positively_regulates GO:0072565 ! endothelial microparticle formation
created_by: midori
creation_date: 2011-01-31T11:20:38Z

[Term]
id: GO:2000338
name: regulation of chemokine (C-X-C motif) ligand 1 production
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chemokine (C-X-C motif) ligand 1 production." [GOC:BHF, GOC:mah]
synonym: "regulation of CXCL1 production" EXACT [GOC:obol]
synonym: "regulation of KC production" EXACT [GOC:obol]
synonym: "regulation of keratinocyte derived chemokine production" EXACT [GOC:obol]
synonym: "regulation of SCYB1 production" EXACT [GOC:obol]
is_a: GO:0032642 ! regulation of chemokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072566 ! chemokine (C-X-C motif) ligand 1 production
relationship: regulates GO:0072566 ! chemokine (C-X-C motif) ligand 1 production
created_by: midori
creation_date: 2011-02-01T10:46:27Z

[Term]
id: GO:2000339
name: negative regulation of chemokine (C-X-C motif) ligand 1 production
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chemokine (C-X-C motif) ligand 1 production." [GOC:BHF, GOC:mah]
synonym: "negative regulation of CXCL1 production" EXACT [GOC:obol]
synonym: "negative regulation of KC production" EXACT [GOC:obol]
synonym: "negative regulation of keratinocyte derived chemokine production" EXACT [GOC:obol]
synonym: "negative regulation of SCYB1 production" EXACT [GOC:obol]
is_a: GO:0032682 ! negative regulation of chemokine production
is_a: GO:2000338 ! regulation of chemokine (C-X-C motif) ligand 1 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072566 ! chemokine (C-X-C motif) ligand 1 production
relationship: negatively_regulates GO:0072566 ! chemokine (C-X-C motif) ligand 1 production
created_by: midori
creation_date: 2011-02-01T10:46:31Z

[Term]
id: GO:2000340
name: positive regulation of chemokine (C-X-C motif) ligand 1 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chemokine (C-X-C motif) ligand 1 production." [GOC:BHF, GOC:mah]
synonym: "positive regulation of CXCL1 production" EXACT [GOC:obol]
synonym: "positive regulation of KC production" EXACT [GOC:obol]
synonym: "positive regulation of keratinocyte derived chemokine production" EXACT [GOC:obol]
synonym: "positive regulation of SCYB1 production" EXACT [GOC:obol]
is_a: GO:0032722 ! positive regulation of chemokine production
is_a: GO:2000338 ! regulation of chemokine (C-X-C motif) ligand 1 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072566 ! chemokine (C-X-C motif) ligand 1 production
relationship: positively_regulates GO:0072566 ! chemokine (C-X-C motif) ligand 1 production
created_by: midori
creation_date: 2011-02-01T10:46:33Z

[Term]
id: GO:2000341
name: regulation of chemokine (C-X-C motif) ligand 2 production
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chemokine (C-X-C motif) ligand 2 production." [GOC:BHF, GOC:mah]
synonym: "regulation of CXCL2 production" EXACT [GOC:obol]
synonym: "regulation of MIP-2 production" EXACT [GOC:obol]
synonym: "regulation of MIP2 production" EXACT [GOC:obol]
synonym: "regulation of SCYB2 production" EXACT [GOC:obol]
is_a: GO:0032642 ! regulation of chemokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072567 ! chemokine (C-X-C motif) ligand 2 production
relationship: regulates GO:0072567 ! chemokine (C-X-C motif) ligand 2 production
created_by: midori
creation_date: 2011-02-01T11:57:14Z

[Term]
id: GO:2000342
name: negative regulation of chemokine (C-X-C motif) ligand 2 production
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chemokine (C-X-C motif) ligand 2 production." [GOC:BHF, GOC:mah]
synonym: "negative regulation of CXCL2 production" EXACT [GOC:obol]
synonym: "negative regulation of MIP-2 production" EXACT [GOC:obol]
synonym: "negative regulation of MIP2 production" EXACT [GOC:obol]
synonym: "negative regulation of SCYB2 production" EXACT [GOC:obol]
is_a: GO:0032682 ! negative regulation of chemokine production
is_a: GO:2000341 ! regulation of chemokine (C-X-C motif) ligand 2 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072567 ! chemokine (C-X-C motif) ligand 2 production
relationship: negatively_regulates GO:0072567 ! chemokine (C-X-C motif) ligand 2 production
created_by: midori
creation_date: 2011-02-01T11:57:17Z

[Term]
id: GO:2000343
name: positive regulation of chemokine (C-X-C motif) ligand 2 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chemokine (C-X-C motif) ligand 2 production." [GOC:BHF, GOC:mah]
synonym: "positive regulation of CXCL2 production" EXACT [GOC:obol]
synonym: "positive regulation of MIP-2 production" EXACT [GOC:obol]
synonym: "positive regulation of MIP2 production" EXACT [GOC:obol]
synonym: "positive regulation of SCYB2 production" EXACT [GOC:obol]
is_a: GO:0032722 ! positive regulation of chemokine production
is_a: GO:2000341 ! regulation of chemokine (C-X-C motif) ligand 2 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072567 ! chemokine (C-X-C motif) ligand 2 production
relationship: positively_regulates GO:0072567 ! chemokine (C-X-C motif) ligand 2 production
created_by: midori
creation_date: 2011-02-01T11:57:20Z

[Term]
id: GO:2000344
name: positive regulation of acrosome reaction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the acrosome reaction." [GOC:obol]
is_a: GO:0043902 ! positive regulation of multi-organism process
is_a: GO:0045956 ! positive regulation of calcium ion-dependent exocytosis
is_a: GO:0060046 ! regulation of acrosome reaction
is_a: GO:2000243 ! positive regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007340 ! acrosome reaction
relationship: positively_regulates GO:0007340 ! acrosome reaction
created_by: yaf
creation_date: 2011-02-01T12:02:18Z

[Term]
id: GO:2000345
name: regulation of hepatocyte proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hepatocyte proliferation." [GOC:BHF, GOC:mah]
is_a: GO:0050678 ! regulation of epithelial cell proliferation
is_a: GO:2000027 ! regulation of organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072574 ! hepatocyte proliferation
relationship: regulates GO:0072574 ! hepatocyte proliferation
created_by: midori
creation_date: 2011-02-03T10:27:15Z

[Term]
id: GO:2000346
name: negative regulation of hepatocyte proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hepatocyte proliferation." [GOC:BHF, GOC:mah]
is_a: GO:0050680 ! negative regulation of epithelial cell proliferation
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000345 ! regulation of hepatocyte proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072574 ! hepatocyte proliferation
relationship: negatively_regulates GO:0072574 ! hepatocyte proliferation
created_by: midori
creation_date: 2011-02-03T10:27:20Z

[Term]
id: GO:2000347
name: positive regulation of hepatocyte proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hepatocyte proliferation." [GOC:BHF, GOC:mah]
is_a: GO:0050679 ! positive regulation of epithelial cell proliferation
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000345 ! regulation of hepatocyte proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072574 ! hepatocyte proliferation
relationship: positively_regulates GO:0072574 ! hepatocyte proliferation
created_by: midori
creation_date: 2011-02-03T10:27:24Z

[Term]
id: GO:2000348
name: regulation of CD40 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of signaling via the CD40 signaling pathway." [GOC:mah]
synonym: "regulation of CD40 signalling pathway" EXACT [GOC:obol]
is_a: GO:0009966 ! regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0023035 ! CD40 signaling pathway
relationship: regulates GO:0023035 ! CD40 signaling pathway
created_by: midori
creation_date: 2011-02-03T10:29:40Z

[Term]
id: GO:2000349
name: negative regulation of CD40 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of signaling via the CD40 signaling pathway." [GOC:BHF, GOC:mah]
synonym: "negative regulation of CD40 signalling pathway" EXACT [GOC:obol]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:2000348 ! regulation of CD40 signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0023035 ! CD40 signaling pathway
relationship: negatively_regulates GO:0023035 ! CD40 signaling pathway
created_by: midori
creation_date: 2011-02-03T10:29:44Z

[Term]
id: GO:2000350
name: positive regulation of CD40 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of signaling via the CD40 signaling pathway." [GOC:BHF, GOC:mah]
synonym: "positive regulation of CD40 signalling pathway" EXACT [GOC:obol]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:2000348 ! regulation of CD40 signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0023035 ! CD40 signaling pathway
relationship: positively_regulates GO:0023035 ! CD40 signaling pathway
created_by: midori
creation_date: 2011-02-03T10:29:46Z

[Term]
id: GO:2000351
name: regulation of endothelial cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endothelial cell apoptotic process." [GOC:mah, GOC:mtg_apoptosis]
synonym: "regulation of apoptosis of endothelial cells" EXACT [GOC:obol]
synonym: "regulation of endothelial cell apoptosis" NARROW []
synonym: "regulation of endothelial cell programmed cell death by apoptosis" EXACT [GOC:obol]
synonym: "regulation of killing of endothelial cells" EXACT [GOC:obol]
synonym: "regulation of programmed cell death of endothelial cells by apoptosis" EXACT [GOC:obol]
synonym: "regulation of programmed cell death, endothelial cells" EXACT [GOC:obol]
is_a: GO:1904035 ! regulation of epithelial cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072577 ! endothelial cell apoptotic process
relationship: regulates GO:0072577 ! endothelial cell apoptotic process
created_by: midori
creation_date: 2011-02-03T10:43:16Z

[Term]
id: GO:2000352
name: negative regulation of endothelial cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell apoptotic process." [GOC:BHF, GOC:mah, GOC:mtg_apoptosis]
synonym: "negative regulation of apoptosis of endothelial cells" EXACT [GOC:obol]
synonym: "negative regulation of endothelial cell apoptosis" NARROW []
synonym: "negative regulation of endothelial cell programmed cell death by apoptosis" EXACT [GOC:obol]
synonym: "negative regulation of killing of endothelial cells" EXACT [GOC:obol]
synonym: "negative regulation of programmed cell death of endothelial cells by apoptosis" EXACT [GOC:obol]
synonym: "negative regulation of programmed cell death, endothelial cells" EXACT [GOC:obol]
is_a: GO:1904036 ! negative regulation of epithelial cell apoptotic process
is_a: GO:2000351 ! regulation of endothelial cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072577 ! endothelial cell apoptotic process
relationship: negatively_regulates GO:0072577 ! endothelial cell apoptotic process
created_by: midori
creation_date: 2011-02-03T10:43:20Z

[Term]
id: GO:2000353
name: positive regulation of endothelial cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endothelial cell apoptotic process." [GOC:BHF, GOC:mah, GOC:mtg_apoptosis]
synonym: "positive regulation of apoptosis of endothelial cells" EXACT [GOC:obol]
synonym: "positive regulation of endothelial cell apoptosis" NARROW []
synonym: "positive regulation of endothelial cell programmed cell death by apoptosis" EXACT [GOC:obol]
synonym: "positive regulation of killing of endothelial cells" EXACT [GOC:obol]
synonym: "positive regulation of programmed cell death of endothelial cells by apoptosis" EXACT [GOC:obol]
synonym: "positive regulation of programmed cell death, endothelial cells" EXACT [GOC:obol]
is_a: GO:1904037 ! positive regulation of epithelial cell apoptotic process
is_a: GO:2000351 ! regulation of endothelial cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072577 ! endothelial cell apoptotic process
relationship: positively_regulates GO:0072577 ! endothelial cell apoptotic process
created_by: midori
creation_date: 2011-02-03T10:43:23Z

[Term]
id: GO:2000354
name: regulation of ovarian follicle development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ovarian follicle development." [GOC:obol]
synonym: "regulation of follicular phase" RELATED [GOC:obol]
is_a: GO:2000194 ! regulation of female gonad development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001541 ! ovarian follicle development
relationship: regulates GO:0001541 ! ovarian follicle development
created_by: yaf
creation_date: 2011-02-03T02:01:28Z

[Term]
id: GO:2000355
name: negative regulation of ovarian follicle development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ovarian follicle development." [GOC:obol]
synonym: "negative regulation of follicular phase" RELATED [GOC:obol]
is_a: GO:2000195 ! negative regulation of female gonad development
is_a: GO:2000354 ! regulation of ovarian follicle development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001541 ! ovarian follicle development
relationship: negatively_regulates GO:0001541 ! ovarian follicle development
created_by: yaf
creation_date: 2011-02-03T02:01:32Z

[Term]
id: GO:2000356
name: regulation of kidney smooth muscle cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of kidney smooth muscle cell differentiation." [GOC:obol]
is_a: GO:0051150 ! regulation of smooth muscle cell differentiation
is_a: GO:0090183 ! regulation of kidney development
is_a: GO:1901861 ! regulation of muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072195 ! kidney smooth muscle cell differentiation
relationship: regulates GO:0072195 ! kidney smooth muscle cell differentiation
created_by: yaf
creation_date: 2011-02-03T02:14:24Z

[Term]
id: GO:2000357
name: negative regulation of kidney smooth muscle cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of kidney smooth muscle cell differentiation." [GOC:obol]
is_a: GO:0051151 ! negative regulation of smooth muscle cell differentiation
is_a: GO:0090185 ! negative regulation of kidney development
is_a: GO:1901862 ! negative regulation of muscle tissue development
is_a: GO:2000356 ! regulation of kidney smooth muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072195 ! kidney smooth muscle cell differentiation
relationship: negatively_regulates GO:0072195 ! kidney smooth muscle cell differentiation
created_by: yaf
creation_date: 2011-02-03T02:14:28Z

[Term]
id: GO:2000358
name: positive regulation of kidney smooth muscle cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of kidney smooth muscle cell differentiation." [GOC:obol]
is_a: GO:0051152 ! positive regulation of smooth muscle cell differentiation
is_a: GO:0090184 ! positive regulation of kidney development
is_a: GO:1901863 ! positive regulation of muscle tissue development
is_a: GO:2000356 ! regulation of kidney smooth muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072195 ! kidney smooth muscle cell differentiation
relationship: positively_regulates GO:0072195 ! kidney smooth muscle cell differentiation
created_by: yaf
creation_date: 2011-02-03T02:14:31Z

[Term]
id: GO:2000359
name: regulation of binding of sperm to zona pellucida
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of binding of sperm to the zona pellucida." [GOC:obol]
synonym: "regulation of ZPG binding" RELATED [GOC:obol]
is_a: GO:0043900 ! regulation of multi-organism process
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:0051239 ! regulation of multicellular organismal process
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007339 ! binding of sperm to zona pellucida
relationship: regulates GO:0007339 ! binding of sperm to zona pellucida
created_by: yaf
creation_date: 2011-02-03T02:42:50Z

[Term]
id: GO:2000360
name: negative regulation of binding of sperm to zona pellucida
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of binding of sperm to the zona pellucida." [GOC:obol]
synonym: "negative regulation of ZPG binding" RELATED [GOC:obol]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0060467 ! negative regulation of fertilization
is_a: GO:2000359 ! regulation of binding of sperm to zona pellucida
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007339 ! binding of sperm to zona pellucida
relationship: negatively_regulates GO:0007339 ! binding of sperm to zona pellucida
created_by: yaf
creation_date: 2011-02-03T02:42:54Z

[Term]
id: GO:2000361
name: regulation of prostaglandin-E synthase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of prostaglandin-E synthase activity." [GOC:BHF]
synonym: "regulation of (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate E-isomerase activity" EXACT [GOC:obol]
synonym: "regulation of endoperoxide isomerase activity" EXACT [GOC:obol]
synonym: "regulation of PGE isomerase activity" EXACT [GOC:obol]
synonym: "regulation of PGE2 isomerase activity" EXACT [GOC:obol]
synonym: "regulation of PGH-PGE isomerase activity" EXACT [GOC:obol]
synonym: "regulation of prostaglandin endoperoxide E isomerase activity" EXACT [GOC:obol]
synonym: "regulation of prostaglandin endoperoxide E2 isomerase activity" EXACT [GOC:obol]
synonym: "regulation of prostaglandin H-E isomerase activity" EXACT [GOC:obol]
synonym: "regulation of prostaglandin R-prostaglandin E isomerase activity" EXACT [GOC:obol]
synonym: "regulation of Prostaglandin-H(2) E-isomerase activity" EXACT [GOC:obol]
synonym: "regulation of prostaglandin-H2 E-isomerase activity" EXACT [GOC:obol]
is_a: GO:0010911 ! regulation of isomerase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050220 ! prostaglandin-E synthase activity
relationship: regulates GO:0050220 ! prostaglandin-E synthase activity
created_by: rfoulger
creation_date: 2011-02-03T04:05:35Z

[Term]
id: GO:2000362
name: negative regulation of prostaglandin-E synthase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of prostaglandin-E synthase activity." [GOC:BHF]
synonym: "negative regulation of (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate E-isomerase activity" EXACT [GOC:obol]
synonym: "negative regulation of endoperoxide isomerase activity" EXACT [GOC:obol]
synonym: "negative regulation of PGE isomerase activity" EXACT [GOC:obol]
synonym: "negative regulation of PGE2 isomerase activity" EXACT [GOC:obol]
synonym: "negative regulation of PGH-PGE isomerase activity" EXACT [GOC:obol]
synonym: "negative regulation of prostaglandin endoperoxide E isomerase activity" EXACT [GOC:obol]
synonym: "negative regulation of prostaglandin endoperoxide E2 isomerase activity" EXACT [GOC:obol]
synonym: "negative regulation of prostaglandin H-E isomerase activity" EXACT [GOC:obol]
synonym: "negative regulation of prostaglandin R-prostaglandin E isomerase activity" EXACT [GOC:obol]
synonym: "negative regulation of Prostaglandin-H(2) E-isomerase activity" EXACT [GOC:obol]
synonym: "negative regulation of prostaglandin-H2 E-isomerase activity" EXACT [GOC:obol]
is_a: GO:0043086 ! negative regulation of catalytic activity
is_a: GO:2000361 ! regulation of prostaglandin-E synthase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0050220 ! prostaglandin-E synthase activity
relationship: negatively_regulates GO:0050220 ! prostaglandin-E synthase activity
created_by: rfoulger
creation_date: 2011-02-03T04:05:39Z

[Term]
id: GO:2000363
name: positive regulation of prostaglandin-E synthase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of prostaglandin-E synthase activity." [GOC:BHF]
synonym: "positive regulation of (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate E-isomerase activity" EXACT [GOC:obol]
synonym: "positive regulation of endoperoxide isomerase activity" EXACT [GOC:obol]
synonym: "positive regulation of PGE isomerase activity" EXACT [GOC:obol]
synonym: "positive regulation of PGE2 isomerase activity" EXACT [GOC:obol]
synonym: "positive regulation of PGH-PGE isomerase activity" EXACT [GOC:obol]
synonym: "positive regulation of prostaglandin endoperoxide E isomerase activity" EXACT [GOC:obol]
synonym: "positive regulation of prostaglandin endoperoxide E2 isomerase activity" EXACT [GOC:obol]
synonym: "positive regulation of prostaglandin H-E isomerase activity" EXACT [GOC:obol]
synonym: "positive regulation of prostaglandin R-prostaglandin E isomerase activity" EXACT [GOC:obol]
synonym: "positive regulation of Prostaglandin-H(2) E-isomerase activity" EXACT [GOC:obol]
synonym: "positive regulation of prostaglandin-H2 E-isomerase activity" EXACT [GOC:obol]
is_a: GO:0010912 ! positive regulation of isomerase activity
is_a: GO:2000361 ! regulation of prostaglandin-E synthase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0050220 ! prostaglandin-E synthase activity
relationship: positively_regulates GO:0050220 ! prostaglandin-E synthase activity
created_by: rfoulger
creation_date: 2011-02-03T04:05:42Z

[Term]
id: GO:2000364
name: regulation of STAT protein import into nucleus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of STAT protein import into nucleus." [GOC:BHF]
synonym: "regulation of STAT protein nuclear translocation" RELATED [GOC:obol]
is_a: GO:0042306 ! regulation of protein import into nucleus
is_a: GO:0046425 ! regulation of JAK-STAT cascade
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007262 ! STAT protein import into nucleus
relationship: regulates GO:0007262 ! STAT protein import into nucleus
created_by: vk
creation_date: 2011-02-07T09:35:46Z

[Term]
id: GO:2000365
name: negative regulation of STAT protein import into nucleus
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of STAT protein import into nucleus." [GOC:BHF]
synonym: "negative regulation of STAT protein nuclear translocation" RELATED [GOC:obol]
is_a: GO:0042308 ! negative regulation of protein import into nucleus
is_a: GO:0046426 ! negative regulation of JAK-STAT cascade
is_a: GO:2000364 ! regulation of STAT protein import into nucleus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007262 ! STAT protein import into nucleus
relationship: negatively_regulates GO:0007262 ! STAT protein import into nucleus
created_by: vk
creation_date: 2011-02-07T09:35:57Z

[Term]
id: GO:2000366
name: positive regulation of STAT protein import into nucleus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of STAT protein import into nucleus." [GOC:BHF]
synonym: "positive regulation of STAT protein nuclear translocation" RELATED [GOC:obol]
is_a: GO:0042307 ! positive regulation of protein import into nucleus
is_a: GO:0046427 ! positive regulation of JAK-STAT cascade
is_a: GO:2000364 ! regulation of STAT protein import into nucleus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007262 ! STAT protein import into nucleus
relationship: positively_regulates GO:0007262 ! STAT protein import into nucleus
created_by: vk
creation_date: 2011-02-07T09:36:06Z

[Term]
id: GO:2000367
name: regulation of acrosomal vesicle exocytosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of acrosomal vesicle exocytosis." [GOC:obol]
synonym: "regulation of acrosomal granule exocytosis" RELATED [GOC:obol]
synonym: "regulation of acrosome exocytosis" EXACT [GOC:obol]
is_a: GO:0060046 ! regulation of acrosome reaction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060478 ! acrosomal vesicle exocytosis
relationship: regulates GO:0060478 ! acrosomal vesicle exocytosis
created_by: yaf
creation_date: 2011-02-07T11:52:34Z

[Term]
id: GO:2000368
name: positive regulation of acrosomal vesicle exocytosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of acrosomal vesicle exocytosis." [GOC:obol]
synonym: "positive regulation of acrosomal granule exocytosis" RELATED [GOC:obol]
synonym: "positive regulation of acrosome exocytosis" EXACT [GOC:obol]
is_a: GO:2000344 ! positive regulation of acrosome reaction
is_a: GO:2000367 ! regulation of acrosomal vesicle exocytosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060478 ! acrosomal vesicle exocytosis
relationship: positively_regulates GO:0060478 ! acrosomal vesicle exocytosis
created_by: yaf
creation_date: 2011-02-07T11:52:42Z

[Term]
id: GO:2000369
name: regulation of clathrin-mediated endocytosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of clathrin-mediated endocytosis." [GOC:mah]
synonym: "regulation of clathrin coated pit-dependent endocytosis" EXACT [GOC:obol]
synonym: "regulation of clathrin-dependent endocytosis" EXACT [GOC:obol]
is_a: GO:0048259 ! regulation of receptor-mediated endocytosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072583 ! clathrin-mediated endocytosis
relationship: regulates GO:0072583 ! clathrin-mediated endocytosis
created_by: midori
creation_date: 2011-02-09T12:36:18Z

[Term]
id: GO:2000370
name: positive regulation of clathrin-mediated endocytosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of clathrin-mediated endocytosis." [GOC:BHF, GOC:mah]
synonym: "positive regulation of clathrin coated pit-dependent endocytosis" EXACT [GOC:obol]
synonym: "positive regulation of clathrin-dependent endocytosis" EXACT [GOC:obol]
is_a: GO:0048260 ! positive regulation of receptor-mediated endocytosis
is_a: GO:2000369 ! regulation of clathrin-mediated endocytosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072583 ! clathrin-mediated endocytosis
relationship: positively_regulates GO:0072583 ! clathrin-mediated endocytosis
created_by: midori
creation_date: 2011-02-09T12:36:28Z

[Term]
id: GO:2000371
name: regulation of DNA topoisomerase (ATP-hydrolyzing) activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA topoisomerase (ATP-hydrolyzing) activity." [GOC:mah]
synonym: "regulation of deoxyribonucleate topoisomerase" RELATED [GOC:obol]
synonym: "regulation of deoxyribonucleic topoisomerase activity" EXACT [GOC:obol]
synonym: "regulation of DNA topoisomerase (ATP-hydrolysing)" RELATED [GOC:obol]
synonym: "regulation of DNA topoisomerase II" RELATED [GOC:obol]
synonym: "regulation of DNA topoisomerase IV activity" EXACT [GOC:obol]
synonym: "regulation of DNA topoisomerase type II activity" EXACT [GOC:obol]
synonym: "regulation of topoisomerase" RELATED [GOC:obol]
synonym: "regulation of topoisomerase II" EXACT [GOC:obol]
synonym: "regulation of type II DNA topoisomerase activity" EXACT [GOC:obol]
is_a: GO:0010911 ! regulation of isomerase activity
is_a: GO:0043462 ! regulation of ATPase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003918 ! DNA topoisomerase type II (ATP-hydrolyzing) activity
relationship: regulates GO:0003918 ! DNA topoisomerase type II (ATP-hydrolyzing) activity
created_by: midori
creation_date: 2011-02-09T02:35:27Z

[Term]
id: GO:2000372
name: negative regulation of DNA topoisomerase (ATP-hydrolyzing) activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA topoisomerase (ATP-hydrolyzing) activity." [GOC:mah]
synonym: "negative regulation of deoxyribonucleate topoisomerase" RELATED [GOC:obol]
synonym: "negative regulation of deoxyribonucleic topoisomerase activity" EXACT [GOC:obol]
synonym: "negative regulation of DNA topoisomerase (ATP-hydrolysing)" RELATED [GOC:obol]
synonym: "negative regulation of DNA topoisomerase II" RELATED [GOC:obol]
synonym: "negative regulation of DNA topoisomerase IV activity" EXACT [GOC:obol]
synonym: "negative regulation of DNA topoisomerase type II activity" EXACT [GOC:obol]
synonym: "negative regulation of topoisomerase" RELATED [GOC:obol]
synonym: "negative regulation of topoisomerase II" EXACT [GOC:obol]
synonym: "negative regulation of type II DNA topoisomerase activity" EXACT [GOC:obol]
is_a: GO:0032780 ! negative regulation of ATPase activity
is_a: GO:2000371 ! regulation of DNA topoisomerase (ATP-hydrolyzing) activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003918 ! DNA topoisomerase type II (ATP-hydrolyzing) activity
relationship: negatively_regulates GO:0003918 ! DNA topoisomerase type II (ATP-hydrolyzing) activity
created_by: midori
creation_date: 2011-02-09T02:35:36Z

[Term]
id: GO:2000373
name: positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA topoisomerase (ATP-hydrolyzing) activity." [GOC:mah]
synonym: "positive regulation of deoxyribonucleate topoisomerase" RELATED [GOC:obol]
synonym: "positive regulation of deoxyribonucleic topoisomerase activity" EXACT [GOC:obol]
synonym: "positive regulation of DNA topoisomerase (ATP-hydrolysing)" RELATED [GOC:obol]
synonym: "positive regulation of DNA topoisomerase II" RELATED [GOC:obol]
synonym: "positive regulation of DNA topoisomerase IV activity" EXACT [GOC:obol]
synonym: "positive regulation of DNA topoisomerase type II activity" EXACT [GOC:obol]
synonym: "positive regulation of topoisomerase" RELATED [GOC:obol]
synonym: "positive regulation of topoisomerase II" EXACT [GOC:obol]
synonym: "positive regulation of type II DNA topoisomerase activity" EXACT [GOC:obol]
is_a: GO:0010912 ! positive regulation of isomerase activity
is_a: GO:0032781 ! positive regulation of ATPase activity
is_a: GO:2000371 ! regulation of DNA topoisomerase (ATP-hydrolyzing) activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003918 ! DNA topoisomerase type II (ATP-hydrolyzing) activity
relationship: positively_regulates GO:0003918 ! DNA topoisomerase type II (ATP-hydrolyzing) activity
created_by: midori
creation_date: 2011-02-09T02:35:43Z

[Term]
id: GO:2000374
name: regulation of oxygen metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of oxygen metabolic process." [GOC:mah]
synonym: "regulation of diatomic oxygen metabolic process" EXACT [GOC:obol]
synonym: "regulation of oxygen metabolism" EXACT [GOC:obol]
is_a: GO:0031323 ! regulation of cellular metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072592 ! oxygen metabolic process
relationship: regulates GO:0072592 ! oxygen metabolic process
created_by: midori
creation_date: 2011-02-11T02:03:32Z

[Term]
id: GO:2000375
name: negative regulation of oxygen metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of oxygen metabolic process." [GOC:mah]
synonym: "negative regulation of diatomic oxygen metabolic process" EXACT [GOC:obol]
synonym: "negative regulation of oxygen metabolism" EXACT [GOC:obol]
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:2000374 ! regulation of oxygen metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072592 ! oxygen metabolic process
relationship: negatively_regulates GO:0072592 ! oxygen metabolic process
created_by: midori
creation_date: 2011-02-11T02:03:44Z

[Term]
id: GO:2000376
name: positive regulation of oxygen metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of oxygen metabolic process." [GOC:mah]
synonym: "positive regulation of diatomic oxygen metabolic process" EXACT [GOC:obol]
synonym: "positive regulation of oxygen metabolism" EXACT [GOC:obol]
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:2000374 ! regulation of oxygen metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072592 ! oxygen metabolic process
relationship: positively_regulates GO:0072592 ! oxygen metabolic process
created_by: midori
creation_date: 2011-02-11T02:03:52Z

[Term]
id: GO:2000377
name: regulation of reactive oxygen species metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of reactive oxygen species metabolic process." [GOC:mah]
synonym: "regulation of reactive oxygen species metabolism" EXACT [GOC:obol]
synonym: "regulation of ROS metabolic process" EXACT [GOC:obol]
is_a: GO:0031323 ! regulation of cellular metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072593 ! reactive oxygen species metabolic process
relationship: regulates GO:0072593 ! reactive oxygen species metabolic process
created_by: midori
creation_date: 2011-02-11T02:06:36Z

[Term]
id: GO:2000378
name: negative regulation of reactive oxygen species metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species metabolic process." [GOC:mah]
synonym: "negative regulation of reactive oxygen species metabolism" EXACT [GOC:obol]
synonym: "negative regulation of ROS metabolic process" EXACT [GOC:obol]
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:2000377 ! regulation of reactive oxygen species metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072593 ! reactive oxygen species metabolic process
relationship: negatively_regulates GO:0072593 ! reactive oxygen species metabolic process
created_by: midori
creation_date: 2011-02-11T02:06:49Z

[Term]
id: GO:2000379
name: positive regulation of reactive oxygen species metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process." [GOC:mah]
synonym: "positive regulation of reactive oxygen species metabolism" EXACT [GOC:obol]
synonym: "positive regulation of ROS metabolic process" EXACT [GOC:obol]
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:2000377 ! regulation of reactive oxygen species metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072593 ! reactive oxygen species metabolic process
relationship: positively_regulates GO:0072593 ! reactive oxygen species metabolic process
created_by: midori
creation_date: 2011-02-11T02:06:57Z

[Term]
id: GO:2000380
name: regulation of mesoderm development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesoderm development." [GOC:BHF]
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007498 ! mesoderm development
relationship: regulates GO:0007498 ! mesoderm development
created_by: vk
creation_date: 2011-02-15T03:09:46Z

[Term]
id: GO:2000381
name: negative regulation of mesoderm development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm development." [GOC:BHF]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:2000380 ! regulation of mesoderm development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007498 ! mesoderm development
relationship: negatively_regulates GO:0007498 ! mesoderm development
created_by: vk
creation_date: 2011-02-15T03:10:02Z

[Term]
id: GO:2000382
name: positive regulation of mesoderm development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mesoderm development." [GOC:BHF]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:2000380 ! regulation of mesoderm development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007498 ! mesoderm development
relationship: positively_regulates GO:0007498 ! mesoderm development
created_by: vk
creation_date: 2011-02-15T03:10:12Z

[Term]
id: GO:2000383
name: regulation of ectoderm development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ectoderm development." [GOC:BHF]
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007398 ! ectoderm development
relationship: regulates GO:0007398 ! ectoderm development
created_by: vk
creation_date: 2011-02-15T03:17:10Z

[Term]
id: GO:2000384
name: negative regulation of ectoderm development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ectoderm development." [GOC:BHF]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:2000383 ! regulation of ectoderm development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007398 ! ectoderm development
relationship: negatively_regulates GO:0007398 ! ectoderm development
created_by: vk
creation_date: 2011-02-15T03:17:27Z

[Term]
id: GO:2000385
name: positive regulation of ectoderm development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ectoderm development." [GOC:BHF]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:2000383 ! regulation of ectoderm development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007398 ! ectoderm development
relationship: positively_regulates GO:0007398 ! ectoderm development
created_by: vk
creation_date: 2011-02-15T03:17:39Z

[Term]
id: GO:2000386
name: positive regulation of ovarian follicle development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ovarian follicle development." [GOC:obol]
synonym: "positive regulation of follicular phase" RELATED [GOC:obol]
is_a: GO:2000196 ! positive regulation of female gonad development
is_a: GO:2000354 ! regulation of ovarian follicle development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001541 ! ovarian follicle development
relationship: positively_regulates GO:0001541 ! ovarian follicle development
created_by: yaf
creation_date: 2011-02-16T02:21:21Z

[Term]
id: GO:2000387
name: regulation of antral ovarian follicle growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of antral ovarian follicle growth." [GOC:obol]
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:2000354 ! regulation of ovarian follicle development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001547 ! antral ovarian follicle growth
relationship: regulates GO:0001547 ! antral ovarian follicle growth
created_by: yaf
creation_date: 2011-02-16T04:53:43Z

[Term]
id: GO:2000388
name: positive regulation of antral ovarian follicle growth
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of antral ovarian follicle growth." [GOC:obol]
is_a: GO:0048639 ! positive regulation of developmental growth
is_a: GO:2000386 ! positive regulation of ovarian follicle development
is_a: GO:2000387 ! regulation of antral ovarian follicle growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001547 ! antral ovarian follicle growth
relationship: positively_regulates GO:0001547 ! antral ovarian follicle growth
created_by: yaf
creation_date: 2011-02-16T04:54:01Z

[Term]
id: GO:2000389
name: regulation of neutrophil extravasation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neutrophil extravasation." [GOC:mah]
is_a: GO:0002691 ! regulation of cellular extravasation
is_a: GO:1902622 ! regulation of neutrophil migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072672 ! neutrophil extravasation
relationship: regulates GO:0072672 ! neutrophil extravasation
created_by: midori
creation_date: 2011-02-22T11:07:58Z

[Term]
id: GO:2000390
name: negative regulation of neutrophil extravasation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of neutrophil extravasation." [GOC:BHF, GOC:mah]
is_a: GO:0002692 ! negative regulation of cellular extravasation
is_a: GO:1902623 ! negative regulation of neutrophil migration
is_a: GO:2000389 ! regulation of neutrophil extravasation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072672 ! neutrophil extravasation
relationship: negatively_regulates GO:0072672 ! neutrophil extravasation
created_by: midori
creation_date: 2011-02-22T11:08:23Z

[Term]
id: GO:2000391
name: positive regulation of neutrophil extravasation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neutrophil extravasation." [GOC:BHF, GOC:mah]
is_a: GO:0002693 ! positive regulation of cellular extravasation
is_a: GO:1902624 ! positive regulation of neutrophil migration
is_a: GO:2000389 ! regulation of neutrophil extravasation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072672 ! neutrophil extravasation
relationship: positively_regulates GO:0072672 ! neutrophil extravasation
created_by: midori
creation_date: 2011-02-22T11:08:42Z

[Term]
id: GO:2000392
name: regulation of lamellipodium morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lamellipodium morphogenesis." [GOC:mah]
synonym: "regulation of lamellipodium organization" RELATED [GOC:obol]
is_a: GO:0022604 ! regulation of cell morphogenesis
is_a: GO:1902743 ! regulation of lamellipodium organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072673 ! lamellipodium morphogenesis
relationship: regulates GO:0072673 ! lamellipodium morphogenesis
created_by: midori
creation_date: 2011-02-22T11:18:58Z

[Term]
id: GO:2000393
name: negative regulation of lamellipodium morphogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lamellipodium morphogenesis." [GOC:BHF, GOC:mah]
synonym: "negative regulation of lamellipodium organization" RELATED [GOC:obol]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:1902744 ! negative regulation of lamellipodium organization
is_a: GO:2000392 ! regulation of lamellipodium morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072673 ! lamellipodium morphogenesis
relationship: negatively_regulates GO:0072673 ! lamellipodium morphogenesis
created_by: midori
creation_date: 2011-02-22T11:19:25Z

[Term]
id: GO:2000394
name: positive regulation of lamellipodium morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lamellipodium morphogenesis." [GOC:BHF, GOC:mah]
synonym: "positive regulation of lamellipodium organization" RELATED [GOC:obol]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:1902745 ! positive regulation of lamellipodium organization
is_a: GO:2000392 ! regulation of lamellipodium morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072673 ! lamellipodium morphogenesis
relationship: positively_regulates GO:0072673 ! lamellipodium morphogenesis
created_by: midori
creation_date: 2011-02-22T11:19:45Z

[Term]
id: GO:2000395
name: regulation of ubiquitin-dependent endocytosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ubiquitin-dependent endocytosis." [GOC:mah]
synonym: "regulation of ubiquitin-mediated endocytosis" EXACT [GOC:obol]
is_a: GO:0030100 ! regulation of endocytosis
is_a: GO:0051223 ! regulation of protein transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070086 ! ubiquitin-dependent endocytosis
relationship: regulates GO:0070086 ! ubiquitin-dependent endocytosis
created_by: midori
creation_date: 2011-02-22T11:24:52Z

[Term]
id: GO:2000396
name: negative regulation of ubiquitin-dependent endocytosis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin-dependent endocytosis." [GOC:mah]
synonym: "negative regulation of ubiquitin-mediated endocytosis" EXACT [GOC:obol]
is_a: GO:0045806 ! negative regulation of endocytosis
is_a: GO:0051224 ! negative regulation of protein transport
is_a: GO:2000395 ! regulation of ubiquitin-dependent endocytosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070086 ! ubiquitin-dependent endocytosis
relationship: negatively_regulates GO:0070086 ! ubiquitin-dependent endocytosis
created_by: midori
creation_date: 2011-02-22T11:25:21Z

[Term]
id: GO:2000397
name: positive regulation of ubiquitin-dependent endocytosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ubiquitin-dependent endocytosis." [GOC:mah]
synonym: "positive regulation of ubiquitin-mediated endocytosis" EXACT [GOC:obol]
is_a: GO:0045807 ! positive regulation of endocytosis
is_a: GO:0051222 ! positive regulation of protein transport
is_a: GO:2000395 ! regulation of ubiquitin-dependent endocytosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070086 ! ubiquitin-dependent endocytosis
relationship: positively_regulates GO:0070086 ! ubiquitin-dependent endocytosis
created_by: midori
creation_date: 2011-02-22T11:25:42Z

[Term]
id: GO:2000398
name: regulation of thymocyte aggregation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of thymocyte aggregation." [GOC:mah]
synonym: "regulation of immature T cell aggregation" RELATED [GOC:obol]
synonym: "regulation of immature T-cell aggregation" RELATED [GOC:obol]
synonym: "regulation of immature T-lymphocyte aggregation" EXACT [GOC:obol]
synonym: "regulation of T cell precursor aggregation" EXACT [GOC:obol]
synonym: "regulation of thymic lymphocyte aggregation" EXACT [GOC:obol]
is_a: GO:0002694 ! regulation of leukocyte activation
is_a: GO:0034110 ! regulation of homotypic cell-cell adhesion
is_a: GO:1903037 ! regulation of leukocyte cell-cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071594 ! thymocyte aggregation
relationship: regulates GO:0071594 ! thymocyte aggregation
created_by: midori
creation_date: 2011-02-22T02:49:19Z

[Term]
id: GO:2000399
name: negative regulation of thymocyte aggregation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of thymocyte aggregation." [GOC:BHF, GOC:mah]
synonym: "negative regulation of immature T cell aggregation" RELATED [GOC:obol]
synonym: "negative regulation of immature T-cell aggregation" RELATED [GOC:obol]
synonym: "negative regulation of immature T-lymphocyte aggregation" EXACT [GOC:obol]
synonym: "negative regulation of T cell precursor aggregation" EXACT [GOC:obol]
synonym: "negative regulation of thymic lymphocyte aggregation" EXACT [GOC:obol]
is_a: GO:0002695 ! negative regulation of leukocyte activation
is_a: GO:0034111 ! negative regulation of homotypic cell-cell adhesion
is_a: GO:1903038 ! negative regulation of leukocyte cell-cell adhesion
is_a: GO:2000398 ! regulation of thymocyte aggregation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071594 ! thymocyte aggregation
relationship: negatively_regulates GO:0071594 ! thymocyte aggregation
created_by: midori
creation_date: 2011-02-22T02:49:44Z

[Term]
id: GO:2000400
name: positive regulation of thymocyte aggregation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of thymocyte aggregation." [GOC:BHF, GOC:mah]
synonym: "positive regulation of immature T cell aggregation" RELATED [GOC:obol]
synonym: "positive regulation of immature T-cell aggregation" RELATED [GOC:obol]
synonym: "positive regulation of immature T-lymphocyte aggregation" EXACT [GOC:obol]
synonym: "positive regulation of T cell precursor aggregation" EXACT [GOC:obol]
synonym: "positive regulation of thymic lymphocyte aggregation" EXACT [GOC:obol]
is_a: GO:0002696 ! positive regulation of leukocyte activation
is_a: GO:0034112 ! positive regulation of homotypic cell-cell adhesion
is_a: GO:1903039 ! positive regulation of leukocyte cell-cell adhesion
is_a: GO:2000398 ! regulation of thymocyte aggregation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071594 ! thymocyte aggregation
relationship: positively_regulates GO:0071594 ! thymocyte aggregation
created_by: midori
creation_date: 2011-02-22T02:50:01Z

[Term]
id: GO:2000401
name: regulation of lymphocyte migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lymphocyte migration." [GOC:mah]
is_a: GO:0002685 ! regulation of leukocyte migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072676 ! lymphocyte migration
relationship: regulates GO:0072676 ! lymphocyte migration
created_by: midori
creation_date: 2011-02-23T10:45:19Z

[Term]
id: GO:2000402
name: negative regulation of lymphocyte migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte migration." [GOC:mah]
is_a: GO:0002686 ! negative regulation of leukocyte migration
is_a: GO:2000401 ! regulation of lymphocyte migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072676 ! lymphocyte migration
relationship: negatively_regulates GO:0072676 ! lymphocyte migration
created_by: midori
creation_date: 2011-02-23T10:45:47Z

[Term]
id: GO:2000403
name: positive regulation of lymphocyte migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lymphocyte migration." [GOC:mah]
is_a: GO:0002687 ! positive regulation of leukocyte migration
is_a: GO:2000401 ! regulation of lymphocyte migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072676 ! lymphocyte migration
relationship: positively_regulates GO:0072676 ! lymphocyte migration
created_by: midori
creation_date: 2011-02-23T10:46:06Z

[Term]
id: GO:2000404
name: regulation of T cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of T cell migration." [GOC:mah]
synonym: "regulation of T lymphocyte migration" EXACT [GOC:obol]
synonym: "regulation of T-cell migration" EXACT [GOC:obol]
synonym: "regulation of T-lymphocyte migration" EXACT [GOC:obol]
is_a: GO:2000401 ! regulation of lymphocyte migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072678 ! T cell migration
relationship: regulates GO:0072678 ! T cell migration
created_by: midori
creation_date: 2011-02-23T10:48:24Z

[Term]
id: GO:2000405
name: negative regulation of T cell migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of T cell migration." [GOC:mah]
synonym: "negative regulation of T lymphocyte migration" EXACT [GOC:obol]
synonym: "negative regulation of T-cell migration" EXACT [GOC:obol]
synonym: "negative regulation of T-lymphocyte migration" EXACT [GOC:obol]
is_a: GO:2000402 ! negative regulation of lymphocyte migration
is_a: GO:2000404 ! regulation of T cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072678 ! T cell migration
relationship: negatively_regulates GO:0072678 ! T cell migration
created_by: midori
creation_date: 2011-02-23T10:48:52Z

[Term]
id: GO:2000406
name: positive regulation of T cell migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T cell migration." [GOC:mah]
synonym: "positive regulation of T lymphocyte migration" EXACT [GOC:obol]
synonym: "positive regulation of T-cell migration" EXACT [GOC:obol]
synonym: "positive regulation of T-lymphocyte migration" EXACT [GOC:obol]
is_a: GO:2000403 ! positive regulation of lymphocyte migration
is_a: GO:2000404 ! regulation of T cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072678 ! T cell migration
relationship: positively_regulates GO:0072678 ! T cell migration
created_by: midori
creation_date: 2011-02-23T10:49:12Z

[Term]
id: GO:2000407
name: regulation of T cell extravasation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of T cell extravasation." [GOC:mah]
synonym: "regulation of T lymphocyte extravasation" EXACT [GOC:obol]
synonym: "regulation of T-cell extravasation" EXACT [GOC:obol]
synonym: "regulation of T-lymphocyte extravasation" EXACT [GOC:obol]
is_a: GO:0002691 ! regulation of cellular extravasation
is_a: GO:2000404 ! regulation of T cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072683 ! T cell extravasation
relationship: regulates GO:0072683 ! T cell extravasation
created_by: midori
creation_date: 2011-02-23T10:51:58Z

[Term]
id: GO:2000408
name: negative regulation of T cell extravasation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of T cell extravasation." [GOC:BHF, GOC:mah]
synonym: "negative regulation of T lymphocyte extravasation" EXACT [GOC:obol]
synonym: "negative regulation of T-cell extravasation" EXACT [GOC:obol]
synonym: "negative regulation of T-lymphocyte extravasation" EXACT [GOC:obol]
is_a: GO:0002692 ! negative regulation of cellular extravasation
is_a: GO:2000405 ! negative regulation of T cell migration
is_a: GO:2000407 ! regulation of T cell extravasation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072683 ! T cell extravasation
relationship: negatively_regulates GO:0072683 ! T cell extravasation
created_by: midori
creation_date: 2011-02-23T10:52:28Z

[Term]
id: GO:2000409
name: positive regulation of T cell extravasation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T cell extravasation." [GOC:BHF, GOC:mah]
synonym: "positive regulation of T lymphocyte extravasation" EXACT [GOC:obol]
synonym: "positive regulation of T-cell extravasation" EXACT [GOC:obol]
synonym: "positive regulation of T-lymphocyte extravasation" EXACT [GOC:obol]
is_a: GO:0002693 ! positive regulation of cellular extravasation
is_a: GO:2000406 ! positive regulation of T cell migration
is_a: GO:2000407 ! regulation of T cell extravasation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072683 ! T cell extravasation
relationship: positively_regulates GO:0072683 ! T cell extravasation
created_by: midori
creation_date: 2011-02-23T10:52:50Z

[Term]
id: GO:2000410
name: regulation of thymocyte migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of thymocyte migration." [GOC:mah]
synonym: "regulation of immature T cell migration" RELATED [GOC:obol]
synonym: "regulation of immature T lymphocyte migration" RELATED [GOC:obol]
synonym: "regulation of immature T-cell migration" RELATED [GOC:obol]
synonym: "regulation of immature T-lymphocyte migration" RELATED [GOC:obol]
synonym: "regulation of thymic lymphocyte migration" EXACT [GOC:obol]
is_a: GO:2000404 ! regulation of T cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072679 ! thymocyte migration
relationship: regulates GO:0072679 ! thymocyte migration
created_by: midori
creation_date: 2011-02-23T01:33:32Z

[Term]
id: GO:2000411
name: negative regulation of thymocyte migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of thymocyte migration." [GOC:mah]
synonym: "negative regulation of immature T cell migration" RELATED [GOC:obol]
synonym: "negative regulation of immature T lymphocyte migration" RELATED [GOC:obol]
synonym: "negative regulation of immature T-cell migration" RELATED [GOC:obol]
synonym: "negative regulation of immature T-lymphocyte migration" RELATED [GOC:obol]
synonym: "negative regulation of thymic lymphocyte migration" EXACT [GOC:obol]
is_a: GO:2000405 ! negative regulation of T cell migration
is_a: GO:2000410 ! regulation of thymocyte migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072679 ! thymocyte migration
relationship: negatively_regulates GO:0072679 ! thymocyte migration
created_by: midori
creation_date: 2011-02-23T01:34:01Z

[Term]
id: GO:2000412
name: positive regulation of thymocyte migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of thymocyte migration." [GOC:mah]
synonym: "positive regulation of immature T cell migration" RELATED [GOC:obol]
synonym: "positive regulation of immature T lymphocyte migration" RELATED [GOC:obol]
synonym: "positive regulation of immature T-cell migration" RELATED [GOC:obol]
synonym: "positive regulation of immature T-lymphocyte migration" RELATED [GOC:obol]
synonym: "positive regulation of thymic lymphocyte migration" EXACT [GOC:obol]
is_a: GO:2000406 ! positive regulation of T cell migration
is_a: GO:2000410 ! regulation of thymocyte migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072679 ! thymocyte migration
relationship: positively_regulates GO:0072679 ! thymocyte migration
created_by: midori
creation_date: 2011-02-23T01:34:23Z

[Term]
id: GO:2000413
name: regulation of fibronectin-dependent thymocyte migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fibronectin-dependent thymocyte migration." [GOC:mah]
synonym: "regulation of fibronectin-dependent immature T cell migration" RELATED [GOC:obol]
synonym: "regulation of fibronectin-dependent immature T lymphocyte migration" RELATED [GOC:obol]
synonym: "regulation of fibronectin-dependent immature T-cell migration" RELATED [GOC:obol]
synonym: "regulation of fibronectin-dependent immature T-lymphocyte migration" RELATED [GOC:obol]
synonym: "regulation of fibronectin-dependent thymic lymphocyte migration" EXACT [GOC:obol]
is_a: GO:2000410 ! regulation of thymocyte migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072681 ! fibronectin-dependent thymocyte migration
relationship: regulates GO:0072681 ! fibronectin-dependent thymocyte migration
created_by: midori
creation_date: 2011-02-23T01:38:08Z

[Term]
id: GO:2000414
name: negative regulation of fibronectin-dependent thymocyte migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of fibronectin-dependent thymocyte migration." [GOC:BHF, GOC:mah]
synonym: "negative regulation of fibronectin-dependent immature T cell migration" RELATED [GOC:obol]
synonym: "negative regulation of fibronectin-dependent immature T lymphocyte migration" RELATED [GOC:obol]
synonym: "negative regulation of fibronectin-dependent immature T-cell migration" RELATED [GOC:obol]
synonym: "negative regulation of fibronectin-dependent immature T-lymphocyte migration" RELATED [GOC:obol]
synonym: "negative regulation of fibronectin-dependent thymic lymphocyte migration" EXACT [GOC:obol]
is_a: GO:2000411 ! negative regulation of thymocyte migration
is_a: GO:2000413 ! regulation of fibronectin-dependent thymocyte migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072681 ! fibronectin-dependent thymocyte migration
relationship: negatively_regulates GO:0072681 ! fibronectin-dependent thymocyte migration
created_by: midori
creation_date: 2011-02-23T01:38:37Z

[Term]
id: GO:2000415
name: positive regulation of fibronectin-dependent thymocyte migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of fibronectin-dependent thymocyte migration." [GOC:BHF, GOC:mah]
synonym: "positive regulation of fibronectin-dependent immature T cell migration" RELATED [GOC:obol]
synonym: "positive regulation of fibronectin-dependent immature T lymphocyte migration" RELATED [GOC:obol]
synonym: "positive regulation of fibronectin-dependent immature T-cell migration" RELATED [GOC:obol]
synonym: "positive regulation of fibronectin-dependent immature T-lymphocyte migration" RELATED [GOC:obol]
synonym: "positive regulation of fibronectin-dependent thymic lymphocyte migration" EXACT [GOC:obol]
is_a: GO:2000412 ! positive regulation of thymocyte migration
is_a: GO:2000413 ! regulation of fibronectin-dependent thymocyte migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072681 ! fibronectin-dependent thymocyte migration
relationship: positively_regulates GO:0072681 ! fibronectin-dependent thymocyte migration
created_by: midori
creation_date: 2011-02-23T01:39:00Z

[Term]
id: GO:2000416
name: regulation of eosinophil migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of eosinophil migration." [GOC:mah]
is_a: GO:0002685 ! regulation of leukocyte migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072677 ! eosinophil migration
relationship: regulates GO:0072677 ! eosinophil migration
created_by: midori
creation_date: 2011-02-23T01:43:23Z

[Term]
id: GO:2000417
name: negative regulation of eosinophil migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of eosinophil migration." [GOC:mah]
is_a: GO:0002686 ! negative regulation of leukocyte migration
is_a: GO:2000416 ! regulation of eosinophil migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072677 ! eosinophil migration
relationship: negatively_regulates GO:0072677 ! eosinophil migration
created_by: midori
creation_date: 2011-02-23T01:43:52Z

[Term]
id: GO:2000418
name: positive regulation of eosinophil migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of eosinophil migration." [GOC:mah]
is_a: GO:0002687 ! positive regulation of leukocyte migration
is_a: GO:2000416 ! regulation of eosinophil migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072677 ! eosinophil migration
relationship: positively_regulates GO:0072677 ! eosinophil migration
created_by: midori
creation_date: 2011-02-23T01:44:14Z

[Term]
id: GO:2000419
name: regulation of eosinophil extravasation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of eosinophil extravasation." [GOC:mah]
is_a: GO:0002691 ! regulation of cellular extravasation
is_a: GO:2000416 ! regulation of eosinophil migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072682 ! eosinophil extravasation
relationship: regulates GO:0072682 ! eosinophil extravasation
created_by: midori
creation_date: 2011-02-23T01:46:47Z

[Term]
id: GO:2000420
name: negative regulation of eosinophil extravasation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of eosinophil extravasation." [GOC:BHF, GOC:mah]
is_a: GO:0002692 ! negative regulation of cellular extravasation
is_a: GO:2000417 ! negative regulation of eosinophil migration
is_a: GO:2000419 ! regulation of eosinophil extravasation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072682 ! eosinophil extravasation
relationship: negatively_regulates GO:0072682 ! eosinophil extravasation
created_by: midori
creation_date: 2011-02-23T01:47:18Z

[Term]
id: GO:2000421
name: positive regulation of eosinophil extravasation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of eosinophil extravasation." [GOC:BHF, GOC:mah]
is_a: GO:0002693 ! positive regulation of cellular extravasation
is_a: GO:2000418 ! positive regulation of eosinophil migration
is_a: GO:2000419 ! regulation of eosinophil extravasation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072682 ! eosinophil extravasation
relationship: positively_regulates GO:0072682 ! eosinophil extravasation
created_by: midori
creation_date: 2011-02-23T01:47:42Z

[Term]
id: GO:2000422
name: regulation of eosinophil chemotaxis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of eosinophil chemotaxis." [GOC:obol]
is_a: GO:0071622 ! regulation of granulocyte chemotaxis
is_a: GO:2000416 ! regulation of eosinophil migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048245 ! eosinophil chemotaxis
relationship: regulates GO:0048245 ! eosinophil chemotaxis
created_by: rfoulger
creation_date: 2011-02-24T01:16:44Z

[Term]
id: GO:2000423
name: negative regulation of eosinophil chemotaxis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of eosinophil chemotaxis." [GOC:obol]
is_a: GO:0071623 ! negative regulation of granulocyte chemotaxis
is_a: GO:2000417 ! negative regulation of eosinophil migration
is_a: GO:2000422 ! regulation of eosinophil chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048245 ! eosinophil chemotaxis
relationship: negatively_regulates GO:0048245 ! eosinophil chemotaxis
created_by: rfoulger
creation_date: 2011-02-24T01:17:12Z

[Term]
id: GO:2000424
name: positive regulation of eosinophil chemotaxis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of eosinophil chemotaxis." [GOC:obol]
is_a: GO:0071624 ! positive regulation of granulocyte chemotaxis
is_a: GO:2000418 ! positive regulation of eosinophil migration
is_a: GO:2000422 ! regulation of eosinophil chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048245 ! eosinophil chemotaxis
relationship: positively_regulates GO:0048245 ! eosinophil chemotaxis
created_by: rfoulger
creation_date: 2011-02-24T01:17:35Z

[Term]
id: GO:2000425
name: regulation of apoptotic cell clearance
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of apoptotic cell clearance." [GOC:obol]
synonym: "regulation of apoptotic cell removal" EXACT [GOC:obol]
synonym: "regulation of efferocytosis" EXACT [GOC:obol]
synonym: "regulation of programmed cell clearance" EXACT [GOC:obol]
is_a: GO:0050764 ! regulation of phagocytosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043277 ! apoptotic cell clearance
relationship: regulates GO:0043277 ! apoptotic cell clearance
created_by: rfoulger
creation_date: 2011-02-25T11:50:11Z

[Term]
id: GO:2000426
name: negative regulation of apoptotic cell clearance
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic cell clearance." [GOC:obol]
synonym: "negative regulation of apoptotic cell removal" EXACT [GOC:obol]
synonym: "negative regulation of efferocytosis" EXACT [GOC:obol]
synonym: "negative regulation of programmed cell clearance" EXACT [GOC:obol]
is_a: GO:0050765 ! negative regulation of phagocytosis
is_a: GO:2000425 ! regulation of apoptotic cell clearance
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043277 ! apoptotic cell clearance
relationship: negatively_regulates GO:0043277 ! apoptotic cell clearance
created_by: rfoulger
creation_date: 2011-02-25T11:50:39Z

[Term]
id: GO:2000427
name: positive regulation of apoptotic cell clearance
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of apoptotic cell clearance." [GOC:obol]
synonym: "positive regulation of apoptotic cell removal" EXACT [GOC:obol]
synonym: "positive regulation of efferocytosis" EXACT [GOC:obol]
synonym: "positive regulation of programmed cell clearance" EXACT [GOC:obol]
is_a: GO:0050766 ! positive regulation of phagocytosis
is_a: GO:2000425 ! regulation of apoptotic cell clearance
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043277 ! apoptotic cell clearance
relationship: positively_regulates GO:0043277 ! apoptotic cell clearance
created_by: rfoulger
creation_date: 2011-02-25T11:50:59Z

[Term]
id: GO:2000428
name: regulation of neutrophil aggregation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neutrophil aggregation." [GOC:BHF]
synonym: "regulation of neutrocyte aggregation" EXACT [GOC:obol]
synonym: "regulation of neutrophil leucocyte aggregation" EXACT [GOC:obol]
synonym: "regulation of neutrophilic leukocyte aggregation" EXACT [GOC:obol]
is_a: GO:0034110 ! regulation of homotypic cell-cell adhesion
is_a: GO:1903037 ! regulation of leukocyte cell-cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070488 ! neutrophil aggregation
relationship: regulates GO:0070488 ! neutrophil aggregation
created_by: ebc
creation_date: 2011-02-28T05:18:54Z

[Term]
id: GO:2000429
name: negative regulation of neutrophil aggregation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of neutrophil aggregation." [GOC:BHF]
synonym: "negative regulation of neutrocyte aggregation" EXACT [GOC:obol]
synonym: "negative regulation of neutrophil leucocyte aggregation" EXACT [GOC:obol]
synonym: "negative regulation of neutrophilic leukocyte aggregation" EXACT [GOC:obol]
is_a: GO:0034111 ! negative regulation of homotypic cell-cell adhesion
is_a: GO:1903038 ! negative regulation of leukocyte cell-cell adhesion
is_a: GO:2000428 ! regulation of neutrophil aggregation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070488 ! neutrophil aggregation
relationship: negatively_regulates GO:0070488 ! neutrophil aggregation
created_by: ebc
creation_date: 2011-02-28T05:19:28Z

[Term]
id: GO:2000430
name: positive regulation of neutrophil aggregation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neutrophil aggregation." [GOC:BHF]
synonym: "positive regulation of neutrocyte aggregation" EXACT [GOC:obol]
synonym: "positive regulation of neutrophil leucocyte aggregation" EXACT [GOC:obol]
synonym: "positive regulation of neutrophilic leukocyte aggregation" EXACT [GOC:obol]
is_a: GO:0034112 ! positive regulation of homotypic cell-cell adhesion
is_a: GO:1903039 ! positive regulation of leukocyte cell-cell adhesion
is_a: GO:2000428 ! regulation of neutrophil aggregation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070488 ! neutrophil aggregation
relationship: positively_regulates GO:0070488 ! neutrophil aggregation
created_by: ebc
creation_date: 2011-02-28T05:19:51Z

[Term]
id: GO:2000431
name: regulation of cytokinesis, actomyosin contractile ring assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cytokinesis, actomyosin contractile ring assembly." [GOC:obol]
synonym: "regulation of contractile ring assembly" EXACT [GOC:obol]
is_a: GO:0032954 ! regulation of cytokinetic process
is_a: GO:0032956 ! regulation of actin cytoskeleton organization
is_a: GO:0044087 ! regulation of cellular component biogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000915 ! actomyosin contractile ring assembly
relationship: regulates GO:0000915 ! actomyosin contractile ring assembly
created_by: vw
creation_date: 2011-03-03T12:17:41Z

[Term]
id: GO:2000432
name: negative regulation of cytokinesis, actomyosin contractile ring assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytokinesis, actomyosin contractile ring assembly." [GOC:obol]
synonym: "negative regulation of contractile ring assembly" EXACT [GOC:obol]
is_a: GO:0032466 ! negative regulation of cytokinesis
is_a: GO:0051494 ! negative regulation of cytoskeleton organization
is_a: GO:2000431 ! regulation of cytokinesis, actomyosin contractile ring assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000915 ! actomyosin contractile ring assembly
relationship: negatively_regulates GO:0000915 ! actomyosin contractile ring assembly
created_by: vw
creation_date: 2011-03-03T12:18:16Z

[Term]
id: GO:2000433
name: positive regulation of cytokinesis, actomyosin contractile ring assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cytokinesis, actomyosin contractile ring assembly." [GOC:obol]
synonym: "positive regulation of contractile ring assembly" EXACT [GOC:obol]
is_a: GO:0032467 ! positive regulation of cytokinesis
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:0051495 ! positive regulation of cytoskeleton organization
is_a: GO:2000431 ! regulation of cytokinesis, actomyosin contractile ring assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000915 ! actomyosin contractile ring assembly
relationship: positively_regulates GO:0000915 ! actomyosin contractile ring assembly
created_by: vw
creation_date: 2011-03-03T12:18:43Z

[Term]
id: GO:2000434
name: regulation of protein neddylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein neddylation." [GOC:obol]
synonym: "regulation of RUB1-protein conjugation" EXACT [GOC:obol]
is_a: GO:1903320 ! regulation of protein modification by small protein conjugation or removal
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045116 ! protein neddylation
relationship: regulates GO:0045116 ! protein neddylation
created_by: vw
creation_date: 2011-03-03T02:05:22Z

[Term]
id: GO:2000435
name: negative regulation of protein neddylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein neddylation." [GOC:obol]
synonym: "negative regulation of RUB1-protein conjugation" EXACT [GOC:obol]
is_a: GO:1903321 ! negative regulation of protein modification by small protein conjugation or removal
is_a: GO:2000434 ! regulation of protein neddylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045116 ! protein neddylation
relationship: negatively_regulates GO:0045116 ! protein neddylation
created_by: vw
creation_date: 2011-03-03T02:05:56Z

[Term]
id: GO:2000436
name: positive regulation of protein neddylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein neddylation." [GOC:obol]
synonym: "positive regulation of RUB1-protein conjugation" EXACT [GOC:obol]
is_a: GO:1903322 ! positive regulation of protein modification by small protein conjugation or removal
is_a: GO:2000434 ! regulation of protein neddylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045116 ! protein neddylation
relationship: positively_regulates GO:0045116 ! protein neddylation
created_by: vw
creation_date: 2011-03-03T02:06:19Z

[Term]
id: GO:2000437
name: regulation of monocyte extravasation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of monocyte extravasation." [GOC:obol]
is_a: GO:0002691 ! regulation of cellular extravasation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035696 ! monocyte extravasation
relationship: regulates GO:0035696 ! monocyte extravasation
created_by: rfoulger
creation_date: 2011-03-04T10:24:08Z

[Term]
id: GO:2000438
name: negative regulation of monocyte extravasation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of monocyte extravasation." [GOC:obol]
is_a: GO:0002692 ! negative regulation of cellular extravasation
is_a: GO:2000437 ! regulation of monocyte extravasation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035696 ! monocyte extravasation
relationship: negatively_regulates GO:0035696 ! monocyte extravasation
created_by: rfoulger
creation_date: 2011-03-04T10:24:44Z

[Term]
id: GO:2000439
name: positive regulation of monocyte extravasation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of monocyte extravasation." [GOC:obol]
is_a: GO:0002693 ! positive regulation of cellular extravasation
is_a: GO:2000437 ! regulation of monocyte extravasation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035696 ! monocyte extravasation
relationship: positively_regulates GO:0035696 ! monocyte extravasation
created_by: rfoulger
creation_date: 2011-03-04T10:25:11Z

[Term]
id: GO:2000440
name: regulation of toll-like receptor 15 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of toll-like receptor 15 signaling pathway." [GOC:obol]
synonym: "regulation of TLR15 signaling pathway" EXACT [GOC:obol]
synonym: "regulation of toll-like receptor 15 signalling pathway" EXACT [GOC:mah]
is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035681 ! toll-like receptor 15 signaling pathway
relationship: regulates GO:0035681 ! toll-like receptor 15 signaling pathway
created_by: rfoulger
creation_date: 2011-03-04T10:28:24Z

[Term]
id: GO:2000441
name: negative regulation of toll-like receptor 15 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of toll-like receptor 15 signaling pathway." [GOC:obol]
synonym: "negative regulation of TLR15 signaling pathway" EXACT [GOC:obol]
synonym: "negative regulation of toll-like receptor 15 signalling pathway" EXACT [GOC:mah]
is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway
is_a: GO:2000440 ! regulation of toll-like receptor 15 signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035681 ! toll-like receptor 15 signaling pathway
relationship: negatively_regulates GO:0035681 ! toll-like receptor 15 signaling pathway
created_by: rfoulger
creation_date: 2011-03-04T10:29:04Z

[Term]
id: GO:2000442
name: positive regulation of toll-like receptor 15 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of toll-like receptor 15 signaling pathway." [GOC:obol]
synonym: "positive regulation of TLR15 signaling pathway" EXACT [GOC:obol]
synonym: "positive regulation of toll-like receptor 15 signalling pathway" EXACT [GOC:mah]
is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway
is_a: GO:2000440 ! regulation of toll-like receptor 15 signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035681 ! toll-like receptor 15 signaling pathway
relationship: positively_regulates GO:0035681 ! toll-like receptor 15 signaling pathway
created_by: rfoulger
creation_date: 2011-03-04T10:29:36Z

[Term]
id: GO:2000443
name: regulation of toll-like receptor 21 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of toll-like receptor 21 signaling pathway." [GOC:obol]
synonym: "regulation of TLR21 signaling pathway" EXACT [GOC:obol]
synonym: "regulation of toll-like receptor 21 signalling pathway" EXACT [GOC:mah]
is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035682 ! toll-like receptor 21 signaling pathway
relationship: regulates GO:0035682 ! toll-like receptor 21 signaling pathway
created_by: rfoulger
creation_date: 2011-03-04T10:31:48Z

[Term]
id: GO:2000444
name: negative regulation of toll-like receptor 21 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of toll-like receptor 21 signaling pathway." [GOC:obol]
synonym: "negative regulation of TLR21 signaling pathway" EXACT [GOC:obol]
synonym: "negative regulation of toll-like receptor 21 signalling pathway" EXACT [GOC:mah]
is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway
is_a: GO:2000443 ! regulation of toll-like receptor 21 signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035682 ! toll-like receptor 21 signaling pathway
relationship: negatively_regulates GO:0035682 ! toll-like receptor 21 signaling pathway
created_by: rfoulger
creation_date: 2011-03-04T10:32:29Z

[Term]
id: GO:2000445
name: positive regulation of toll-like receptor 21 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of toll-like receptor 21 signaling pathway." [GOC:obol]
synonym: "positive regulation of TLR21 signaling pathway" EXACT [GOC:obol]
synonym: "positive regulation of toll-like receptor 21 signalling pathway" EXACT [GOC:mah]
is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway
is_a: GO:2000443 ! regulation of toll-like receptor 21 signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035682 ! toll-like receptor 21 signaling pathway
relationship: positively_regulates GO:0035682 ! toll-like receptor 21 signaling pathway
created_by: rfoulger
creation_date: 2011-03-04T10:33:00Z

[Term]
id: GO:2000446
name: regulation of macrophage migration inhibitory factor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of macrophage migration inhibitory factor signaling pathway." [GOC:obol]
synonym: "regulation of macrophage migration inhibitory factor signalling pathway" EXACT [GOC:mah]
synonym: "regulation of MIF signaling pathway" EXACT [GOC:obol]
is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035691 ! macrophage migration inhibitory factor signaling pathway
relationship: regulates GO:0035691 ! macrophage migration inhibitory factor signaling pathway
created_by: rfoulger
creation_date: 2011-03-04T10:37:39Z

[Term]
id: GO:2000447
name: negative regulation of macrophage migration inhibitory factor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of macrophage migration inhibitory factor signaling pathway." [GOC:obol]
synonym: "negative regulation of macrophage migration inhibitory factor signalling pathway" EXACT [GOC:mah]
synonym: "negative regulation of MIF signaling pathway" EXACT [GOC:obol]
is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway
is_a: GO:2000446 ! regulation of macrophage migration inhibitory factor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035691 ! macrophage migration inhibitory factor signaling pathway
relationship: negatively_regulates GO:0035691 ! macrophage migration inhibitory factor signaling pathway
created_by: rfoulger
creation_date: 2011-03-04T10:38:15Z

[Term]
id: GO:2000448
name: positive regulation of macrophage migration inhibitory factor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of macrophage migration inhibitory factor signaling pathway." [GOC:obol]
synonym: "positive regulation of macrophage migration inhibitory factor signalling pathway" EXACT [GOC:mah]
synonym: "positive regulation of MIF signaling pathway" EXACT [GOC:obol]
is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway
is_a: GO:2000446 ! regulation of macrophage migration inhibitory factor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035691 ! macrophage migration inhibitory factor signaling pathway
relationship: positively_regulates GO:0035691 ! macrophage migration inhibitory factor signaling pathway
created_by: rfoulger
creation_date: 2011-03-04T10:38:43Z

[Term]
id: GO:2000449
name: regulation of CD8-positive, alpha-beta T cell extravasation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of CD8-positive, alpha-beta T cell extravasation." [GOC:obol]
is_a: GO:2000407 ! regulation of T cell extravasation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035697 ! CD8-positive, alpha-beta T cell extravasation
relationship: regulates GO:0035697 ! CD8-positive, alpha-beta T cell extravasation
created_by: rfoulger
creation_date: 2011-03-04T10:41:03Z

[Term]
id: GO:2000450
name: negative regulation of CD8-positive, alpha-beta T cell extravasation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of CD8-positive, alpha-beta T cell extravasation." [GOC:obol]
is_a: GO:2000408 ! negative regulation of T cell extravasation
is_a: GO:2000449 ! regulation of CD8-positive, alpha-beta T cell extravasation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035697 ! CD8-positive, alpha-beta T cell extravasation
relationship: negatively_regulates GO:0035697 ! CD8-positive, alpha-beta T cell extravasation
created_by: rfoulger
creation_date: 2011-03-04T10:41:43Z

[Term]
id: GO:2000451
name: positive regulation of CD8-positive, alpha-beta T cell extravasation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell extravasation." [GOC:obol]
is_a: GO:2000409 ! positive regulation of T cell extravasation
is_a: GO:2000449 ! regulation of CD8-positive, alpha-beta T cell extravasation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035697 ! CD8-positive, alpha-beta T cell extravasation
relationship: positively_regulates GO:0035697 ! CD8-positive, alpha-beta T cell extravasation
created_by: rfoulger
creation_date: 2011-03-04T10:42:14Z

[Term]
id: GO:2000452
name: regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of CD8-positive, alpha-beta cytotoxic T cell extravasation." [GOC:obol]
is_a: GO:2000449 ! regulation of CD8-positive, alpha-beta T cell extravasation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035698 ! CD8-positive, alpha-beta cytotoxic T cell extravasation
relationship: regulates GO:0035698 ! CD8-positive, alpha-beta cytotoxic T cell extravasation
created_by: rfoulger
creation_date: 2011-03-04T10:44:39Z

[Term]
id: GO:2000453
name: negative regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of CD8-positive, alpha-beta cytotoxic T cell extravasation." [GOC:obol]
is_a: GO:2000450 ! negative regulation of CD8-positive, alpha-beta T cell extravasation
is_a: GO:2000452 ! regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035698 ! CD8-positive, alpha-beta cytotoxic T cell extravasation
relationship: negatively_regulates GO:0035698 ! CD8-positive, alpha-beta cytotoxic T cell extravasation
created_by: rfoulger
creation_date: 2011-03-04T10:45:20Z

[Term]
id: GO:2000454
name: positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta cytotoxic T cell extravasation." [GOC:obol]
is_a: GO:2000451 ! positive regulation of CD8-positive, alpha-beta T cell extravasation
is_a: GO:2000452 ! regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035698 ! CD8-positive, alpha-beta cytotoxic T cell extravasation
relationship: positively_regulates GO:0035698 ! CD8-positive, alpha-beta cytotoxic T cell extravasation
created_by: rfoulger
creation_date: 2011-03-04T10:45:52Z

[Term]
id: GO:2000455
name: regulation of T-helper 17 cell extravasation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of T-helper 17 cell extravasation." [GOC:obol]
is_a: GO:2000449 ! regulation of CD8-positive, alpha-beta T cell extravasation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035699 ! T-helper 17 cell extravasation
relationship: regulates GO:0035699 ! T-helper 17 cell extravasation
created_by: rfoulger
creation_date: 2011-03-04T10:49:51Z

[Term]
id: GO:2000456
name: negative regulation of T-helper 17 cell extravasation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 cell extravasation." [GOC:obol]
is_a: GO:2000450 ! negative regulation of CD8-positive, alpha-beta T cell extravasation
is_a: GO:2000455 ! regulation of T-helper 17 cell extravasation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035699 ! T-helper 17 cell extravasation
relationship: negatively_regulates GO:0035699 ! T-helper 17 cell extravasation
created_by: rfoulger
creation_date: 2011-03-04T10:50:29Z

[Term]
id: GO:2000457
name: positive regulation of T-helper 17 cell extravasation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T-helper 17 cell extravasation." [GOC:obol]
is_a: GO:2000451 ! positive regulation of CD8-positive, alpha-beta T cell extravasation
is_a: GO:2000455 ! regulation of T-helper 17 cell extravasation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035699 ! T-helper 17 cell extravasation
relationship: positively_regulates GO:0035699 ! T-helper 17 cell extravasation
created_by: rfoulger
creation_date: 2011-03-04T10:51:00Z

[Term]
id: GO:2000458
name: regulation of astrocyte chemotaxis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of astrocyte chemotaxis." [GOC:obol]
is_a: GO:0050920 ! regulation of chemotaxis
is_a: GO:1903975 ! regulation of glial cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035700 ! astrocyte chemotaxis
relationship: regulates GO:0035700 ! astrocyte chemotaxis
created_by: rfoulger
creation_date: 2011-03-04T10:53:50Z

[Term]
id: GO:2000459
name: negative regulation of astrocyte chemotaxis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of astrocyte chemotaxis." [GOC:obol]
is_a: GO:0050922 ! negative regulation of chemotaxis
is_a: GO:1903976 ! negative regulation of glial cell migration
is_a: GO:2000458 ! regulation of astrocyte chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035700 ! astrocyte chemotaxis
relationship: negatively_regulates GO:0035700 ! astrocyte chemotaxis
created_by: rfoulger
creation_date: 2011-03-04T10:54:28Z

[Term]
id: GO:2000460
name: obsolete regulation of eukaryotic cell surface binding
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of eukaryotic cell surface binding." [GOC:obol]
comment: This term was made obsolete because the cell surface binding terms are ambiguous grouping terms and were causing confusion.
synonym: "regulation of eukaryotic cell surface binding" EXACT []
is_obsolete: true
consider: GO:0031347
consider: GO:1900120
created_by: yaf
creation_date: 2011-03-04T11:59:52Z

[Term]
id: GO:2000461
name: obsolete negative regulation of eukaryotic cell surface binding
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of eukaryotic cell surface binding." [GOC:obol]
comment: This term was made obsolete because the cell surface binding terms are ambiguous grouping terms and were causing confusion.
synonym: "negative regulation of eukaryotic cell surface binding" EXACT []
is_obsolete: true
consider: GO:0031347
consider: GO:1900121
created_by: yaf
creation_date: 2011-03-04T12:00:26Z

[Term]
id: GO:2000462
name: obsolete positive regulation of eukaryotic cell surface binding
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of eukaryotic cell surface binding." [GOC:obol]
comment: This term was made obsolete because the cell surface binding terms are ambiguous grouping terms and were causing confusion.
synonym: "positive regulation of eukaryotic cell surface binding" EXACT []
is_obsolete: true
consider: GO:0031347
consider: GO:1900122
created_by: yaf
creation_date: 2011-03-04T12:00:49Z

[Term]
id: GO:2000463
name: positive regulation of excitatory postsynaptic potential
namespace: biological_process
def: "Any process that enhances the establishment or increases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." [GOC:bf, GOC:BHF]
synonym: "positive regulation of EPSP" RELATED [GOC:bf, GOC:obol]
synonym: "positive regulation of excitatory post-synaptic membrane potential" EXACT []
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0050806 ! positive regulation of synaptic transmission
is_a: GO:0098815 ! modulation of excitatory postsynaptic potential
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: positively_regulates GO:0060079 ! excitatory postsynaptic potential
relationship: positively_regulates GO:0060079 ! excitatory postsynaptic potential
created_by: rl
creation_date: 2011-03-04T02:43:32Z

[Term]
id: GO:2000464
name: positive regulation of astrocyte chemotaxis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of astrocyte chemotaxis." [GOC:obol]
is_a: GO:0050921 ! positive regulation of chemotaxis
is_a: GO:1903977 ! positive regulation of glial cell migration
is_a: GO:2000458 ! regulation of astrocyte chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035700 ! astrocyte chemotaxis
relationship: positively_regulates GO:0035700 ! astrocyte chemotaxis
created_by: rfoulger
creation_date: 2011-03-04T04:43:29Z

[Term]
id: GO:2000465
name: regulation of glycogen (starch) synthase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glycogen (starch) synthase activity." [GOC:obol]
synonym: "regulation of glycogen (starch) synthetase activity" EXACT [GOC:obol]
synonym: "regulation of UDP-glucose-glycogen glucosyltransferase activity" EXACT [GOC:obol]
synonym: "regulation of UDP-glucose:glycogen 4-alpha-D-glucosyltransferase activity" EXACT [GOC:obol]
synonym: "regulation of UDP-glycogen synthase activity" EXACT [GOC:obol]
synonym: "regulation of UDPG-glycogen synthetase activity" EXACT [GOC:obol]
synonym: "regulation of UDPG-glycogen transglucosylase activity" EXACT [GOC:obol]
synonym: "regulation of UDPglucose:glycogen 4-alpha-D-glucosyltransferase activity" EXACT [GOC:obol]
synonym: "regulation of uridine diphosphoglucose-glycogen glucosyltransferase activity" EXACT [GOC:obol]
is_a: GO:0051338 ! regulation of transferase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004373 ! glycogen (starch) synthase activity
relationship: regulates GO:0004373 ! glycogen (starch) synthase activity
created_by: yaf
creation_date: 2011-03-07T04:12:35Z

[Term]
id: GO:2000466
name: negative regulation of glycogen (starch) synthase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glycogen (starch) synthase activity." [GOC:obol]
synonym: "negative regulation of glycogen (starch) synthetase activity" EXACT [GOC:obol]
synonym: "negative regulation of UDP-glucose-glycogen glucosyltransferase activity" EXACT [GOC:obol]
synonym: "negative regulation of UDP-glucose:glycogen 4-alpha-D-glucosyltransferase activity" EXACT [GOC:obol]
synonym: "negative regulation of UDP-glycogen synthase activity" EXACT [GOC:obol]
synonym: "negative regulation of UDPG-glycogen synthetase activity" EXACT [GOC:obol]
synonym: "negative regulation of UDPG-glycogen transglucosylase activity" EXACT [GOC:obol]
synonym: "negative regulation of UDPglucose:glycogen 4-alpha-D-glucosyltransferase activity" EXACT [GOC:obol]
synonym: "negative regulation of uridine diphosphoglucose-glycogen glucosyltransferase activity" EXACT [GOC:obol]
is_a: GO:0051348 ! negative regulation of transferase activity
is_a: GO:2000465 ! regulation of glycogen (starch) synthase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004373 ! glycogen (starch) synthase activity
relationship: negatively_regulates GO:0004373 ! glycogen (starch) synthase activity
created_by: yaf
creation_date: 2011-03-07T04:13:14Z

[Term]
id: GO:2000467
name: positive regulation of glycogen (starch) synthase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glycogen (starch) synthase activity." [GOC:obol]
synonym: "positive regulation of glycogen (starch) synthetase activity" EXACT [GOC:obol]
synonym: "positive regulation of UDP-glucose-glycogen glucosyltransferase activity" EXACT [GOC:obol]
synonym: "positive regulation of UDP-glucose:glycogen 4-alpha-D-glucosyltransferase activity" EXACT [GOC:obol]
synonym: "positive regulation of UDP-glycogen synthase activity" EXACT [GOC:obol]
synonym: "positive regulation of UDPG-glycogen synthetase activity" EXACT [GOC:obol]
synonym: "positive regulation of UDPG-glycogen transglucosylase activity" EXACT [GOC:obol]
synonym: "positive regulation of UDPglucose:glycogen 4-alpha-D-glucosyltransferase activity" EXACT [GOC:obol]
synonym: "positive regulation of uridine diphosphoglucose-glycogen glucosyltransferase activity" EXACT [GOC:obol]
is_a: GO:0051347 ! positive regulation of transferase activity
is_a: GO:2000465 ! regulation of glycogen (starch) synthase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004373 ! glycogen (starch) synthase activity
relationship: positively_regulates GO:0004373 ! glycogen (starch) synthase activity
created_by: yaf
creation_date: 2011-03-07T04:13:41Z

[Term]
id: GO:2000468
name: regulation of peroxidase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of peroxidase activity." [GOC:obol]
synonym: "regulation of donor:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:obol]
synonym: "regulation of oxyperoxidase activity" EXACT [GOC:obol]
synonym: "regulation of peroxidase reaction" EXACT [GOC:obol]
is_a: GO:0048583 ! regulation of response to stimulus
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:0051341 ! regulation of oxidoreductase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004601 ! peroxidase activity
relationship: regulates GO:0004601 ! peroxidase activity
created_by: rfoulger
creation_date: 2011-03-08T02:18:18Z

[Term]
id: GO:2000469
name: negative regulation of peroxidase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of peroxidase activity." [GOC:obol]
synonym: "negative regulation of donor:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:obol]
synonym: "negative regulation of oxyperoxidase activity" EXACT [GOC:obol]
synonym: "negative regulation of peroxidase reaction" EXACT [GOC:obol]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:0051354 ! negative regulation of oxidoreductase activity
is_a: GO:2000468 ! regulation of peroxidase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004601 ! peroxidase activity
relationship: negatively_regulates GO:0004601 ! peroxidase activity
created_by: rfoulger
creation_date: 2011-03-08T02:18:59Z

[Term]
id: GO:2000470
name: positive regulation of peroxidase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of peroxidase activity." [GOC:obol]
synonym: "positive regulation of donor:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:obol]
synonym: "positive regulation of oxyperoxidase activity" EXACT [GOC:obol]
synonym: "positive regulation of peroxidase reaction" EXACT [GOC:obol]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:0051353 ! positive regulation of oxidoreductase activity
is_a: GO:2000468 ! regulation of peroxidase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004601 ! peroxidase activity
relationship: positively_regulates GO:0004601 ! peroxidase activity
created_by: rfoulger
creation_date: 2011-03-08T02:19:25Z

[Term]
id: GO:2000471
name: regulation of hematopoietic stem cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hematopoietic stem cell migration." [GOC:obol]
synonym: "regulation of hemopoietic stem cell migration" EXACT [GOC:obol]
is_a: GO:0030334 ! regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035701 ! hematopoietic stem cell migration
relationship: regulates GO:0035701 ! hematopoietic stem cell migration
created_by: rfoulger
creation_date: 2011-03-09T09:34:08Z

[Term]
id: GO:2000472
name: negative regulation of hematopoietic stem cell migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell migration." [GOC:obol]
synonym: "negative regulation of hemopoietic stem cell migration" EXACT [GOC:obol]
is_a: GO:0030336 ! negative regulation of cell migration
is_a: GO:2000471 ! regulation of hematopoietic stem cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035701 ! hematopoietic stem cell migration
relationship: negatively_regulates GO:0035701 ! hematopoietic stem cell migration
created_by: rfoulger
creation_date: 2011-03-09T09:34:54Z

[Term]
id: GO:2000473
name: positive regulation of hematopoietic stem cell migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell migration." [GOC:obol]
synonym: "positive regulation of hemopoietic stem cell migration" EXACT [GOC:obol]
is_a: GO:0030335 ! positive regulation of cell migration
is_a: GO:2000471 ! regulation of hematopoietic stem cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035701 ! hematopoietic stem cell migration
relationship: positively_regulates GO:0035701 ! hematopoietic stem cell migration
created_by: rfoulger
creation_date: 2011-03-09T09:35:25Z

[Term]
id: GO:2000474
name: regulation of opioid receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of opioid receptor signaling pathway." [GOC:obol]
synonym: "regulation of opioid receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0038003 ! opioid receptor signaling pathway
relationship: regulates GO:0038003 ! opioid receptor signaling pathway
created_by: rfoulger
creation_date: 2011-03-09T09:40:19Z

[Term]
id: GO:2000475
name: negative regulation of opioid receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of opioid receptor signaling pathway." [GOC:obol]
synonym: "negative regulation of opioid receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0045744 ! negative regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:2000474 ! regulation of opioid receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0038003 ! opioid receptor signaling pathway
relationship: negatively_regulates GO:0038003 ! opioid receptor signaling pathway
created_by: rfoulger
creation_date: 2011-03-09T09:41:03Z

[Term]
id: GO:2000476
name: positive regulation of opioid receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of opioid receptor signaling pathway." [GOC:obol]
synonym: "positive regulation of opioid receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0045745 ! positive regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:2000474 ! regulation of opioid receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0038003 ! opioid receptor signaling pathway
relationship: positively_regulates GO:0038003 ! opioid receptor signaling pathway
created_by: rfoulger
creation_date: 2011-03-09T09:41:35Z

[Term]
id: GO:2000477
name: regulation of metanephric glomerular visceral epithelial cell development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of metanephric glomerular visceral epithelial cell development." [GOC:obol]
synonym: "regulation of metanephric podocyte development" RELATED [GOC:obol]
is_a: GO:0060284 ! regulation of cell development
is_a: GO:0072298 ! regulation of metanephric glomerulus development
is_a: GO:2000696 ! regulation of epithelial cell differentiation involved in kidney development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072249 ! metanephric glomerular visceral epithelial cell development
relationship: regulates GO:0072249 ! metanephric glomerular visceral epithelial cell development
created_by: yaf
creation_date: 2011-03-09T05:16:40Z

[Term]
id: GO:2000478
name: positive regulation of metanephric glomerular visceral epithelial cell development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of metanephric glomerular visceral epithelial cell development." [GOC:obol]
synonym: "positive regulation of metanephric podocyte development" RELATED [GOC:obol]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0072300 ! positive regulation of metanephric glomerulus development
is_a: GO:2000477 ! regulation of metanephric glomerular visceral epithelial cell development
is_a: GO:2000698 ! positive regulation of epithelial cell differentiation involved in kidney development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072249 ! metanephric glomerular visceral epithelial cell development
relationship: positively_regulates GO:0072249 ! metanephric glomerular visceral epithelial cell development
created_by: yaf
creation_date: 2011-03-09T05:17:26Z

[Term]
id: GO:2000479
name: regulation of cAMP-dependent protein kinase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cAMP-dependent protein kinase activity." [GOC:obol]
synonym: "regulation of 3',5' cAMP-dependent protein kinase activity" EXACT [GOC:obol]
synonym: "regulation of 3',5'-cAMP-dependent protein kinase activity" EXACT [GOC:obol]
synonym: "regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity" EXACT [GOC:obol]
synonym: "regulation of AMPK" RELATED [GOC:obol]
synonym: "regulation of ATP:protein phosphotransferase (cAMP-dependent) activity" EXACT [GOC:obol]
synonym: "regulation of cAMP-dependent protein kinase, intrinsic catalyst activity" EXACT [GOC:obol]
synonym: "regulation of cyclic AMP-dependent protein kinase activity" EXACT [GOC:obol]
synonym: "regulation of PKA" RELATED [GOC:obol]
synonym: "regulation of PKA C" RELATED [GOC:obol]
synonym: "regulation of protein kinase A activity" RELATED [GOC:obol]
synonym: "regulation of STK22" RELATED [GOC:obol]
is_a: GO:0071900 ! regulation of protein serine/threonine kinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004691 ! cAMP-dependent protein kinase activity
relationship: regulates GO:0004691 ! cAMP-dependent protein kinase activity
created_by: yaf
creation_date: 2011-03-10T11:13:01Z

[Term]
id: GO:2000480
name: negative regulation of cAMP-dependent protein kinase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cAMP-dependent protein kinase activity." [GOC:obol]
synonym: "negative regulation of 3',5' cAMP-dependent protein kinase activity" EXACT [GOC:obol]
synonym: "negative regulation of 3',5'-cAMP-dependent protein kinase activity" EXACT [GOC:obol]
synonym: "negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity" EXACT [GOC:obol]
synonym: "negative regulation of AMPK" RELATED [GOC:obol]
synonym: "negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity" EXACT [GOC:obol]
synonym: "negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity" EXACT [GOC:obol]
synonym: "negative regulation of cyclic AMP-dependent protein kinase activity" EXACT [GOC:obol]
synonym: "negative regulation of PKA" RELATED [GOC:obol]
synonym: "negative regulation of PKA C" RELATED [GOC:obol]
synonym: "negative regulation of protein kinase A activity" RELATED [GOC:obol]
synonym: "negative regulation of STK22" RELATED [GOC:obol]
is_a: GO:0071901 ! negative regulation of protein serine/threonine kinase activity
is_a: GO:2000479 ! regulation of cAMP-dependent protein kinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004691 ! cAMP-dependent protein kinase activity
relationship: negatively_regulates GO:0004691 ! cAMP-dependent protein kinase activity
created_by: yaf
creation_date: 2011-03-10T11:13:45Z

[Term]
id: GO:2000481
name: positive regulation of cAMP-dependent protein kinase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cAMP-dependent protein kinase activity." [GOC:obol]
synonym: "positive regulation of 3',5' cAMP-dependent protein kinase activity" EXACT [GOC:obol]
synonym: "positive regulation of 3',5'-cAMP-dependent protein kinase activity" EXACT [GOC:obol]
synonym: "positive regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity" EXACT [GOC:obol]
synonym: "positive regulation of AMPK" RELATED [GOC:obol]
synonym: "positive regulation of ATP:protein phosphotransferase (cAMP-dependent) activity" EXACT [GOC:obol]
synonym: "positive regulation of cAMP-dependent protein kinase, intrinsic catalyst activity" EXACT [GOC:obol]
synonym: "positive regulation of cyclic AMP-dependent protein kinase activity" EXACT [GOC:obol]
synonym: "positive regulation of PKA" RELATED [GOC:obol]
synonym: "positive regulation of PKA C" RELATED [GOC:obol]
synonym: "positive regulation of protein kinase A activity" RELATED [GOC:obol]
synonym: "positive regulation of STK22" RELATED [GOC:obol]
is_a: GO:0071902 ! positive regulation of protein serine/threonine kinase activity
is_a: GO:2000479 ! regulation of cAMP-dependent protein kinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004691 ! cAMP-dependent protein kinase activity
relationship: positively_regulates GO:0004691 ! cAMP-dependent protein kinase activity
created_by: yaf
creation_date: 2011-03-10T11:14:17Z

[Term]
id: GO:2000482
name: regulation of interleukin-8 secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of interleukin-8 secretion." [GOC:obol]
synonym: "regulation of IL-8 secretion" EXACT [GOC:obol]
is_a: GO:0032677 ! regulation of interleukin-8 production
is_a: GO:0050707 ! regulation of cytokine secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072606 ! interleukin-8 secretion
relationship: regulates GO:0072606 ! interleukin-8 secretion
created_by: yaf
creation_date: 2011-03-10T02:37:11Z

[Term]
id: GO:2000483
name: negative regulation of interleukin-8 secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-8 secretion." [GOC:obol]
synonym: "negative regulation of IL-8 secretion" EXACT [GOC:obol]
is_a: GO:0032717 ! negative regulation of interleukin-8 production
is_a: GO:0050710 ! negative regulation of cytokine secretion
is_a: GO:2000482 ! regulation of interleukin-8 secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072606 ! interleukin-8 secretion
relationship: negatively_regulates GO:0072606 ! interleukin-8 secretion
created_by: yaf
creation_date: 2011-03-10T02:37:51Z

[Term]
id: GO:2000484
name: positive regulation of interleukin-8 secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of interleukin-8 secretion." [GOC:obol]
synonym: "positive regulation of IL-8 secretion" EXACT [GOC:obol]
is_a: GO:0032757 ! positive regulation of interleukin-8 production
is_a: GO:0050715 ! positive regulation of cytokine secretion
is_a: GO:2000482 ! regulation of interleukin-8 secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072606 ! interleukin-8 secretion
relationship: positively_regulates GO:0072606 ! interleukin-8 secretion
created_by: yaf
creation_date: 2011-03-10T02:38:20Z

[Term]
id: GO:2000485
name: regulation of glutamine transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glutamine transport." [GOC:obol]
synonym: "regulation of L-glutamine transport" RELATED [GOC:obol]
is_a: GO:0051955 ! regulation of amino acid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006868 ! glutamine transport
relationship: regulates GO:0006868 ! glutamine transport
created_by: rfoulger
creation_date: 2011-03-11T09:32:23Z

[Term]
id: GO:2000486
name: negative regulation of glutamine transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glutamine transport." [GOC:obol]
synonym: "negative regulation of L-glutamine transport" RELATED [GOC:obol]
is_a: GO:0051956 ! negative regulation of amino acid transport
is_a: GO:2000485 ! regulation of glutamine transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006868 ! glutamine transport
relationship: negatively_regulates GO:0006868 ! glutamine transport
created_by: rfoulger
creation_date: 2011-03-11T09:33:07Z

[Term]
id: GO:2000487
name: positive regulation of glutamine transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glutamine transport." [GOC:obol]
synonym: "positive regulation of L-glutamine transport" RELATED [GOC:obol]
is_a: GO:0051957 ! positive regulation of amino acid transport
is_a: GO:2000485 ! regulation of glutamine transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006868 ! glutamine transport
relationship: positively_regulates GO:0006868 ! glutamine transport
created_by: rfoulger
creation_date: 2011-03-11T09:33:39Z

[Term]
id: GO:2000488
name: positive regulation of brassinosteroid biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of brassinosteroid biosynthetic process." [GOC:obol]
synonym: "positive regulation of brassinosteroid anabolism" EXACT [GOC:obol]
synonym: "positive regulation of brassinosteroid biosynthesis" EXACT [GOC:obol]
synonym: "positive regulation of brassinosteroid formation" EXACT [GOC:obol]
synonym: "positive regulation of brassinosteroid synthesis" EXACT [GOC:obol]
is_a: GO:0010422 ! regulation of brassinosteroid biosynthetic process
is_a: GO:0010893 ! positive regulation of steroid biosynthetic process
is_a: GO:0046886 ! positive regulation of hormone biosynthetic process
is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016132 ! brassinosteroid biosynthetic process
relationship: positively_regulates GO:0016132 ! brassinosteroid biosynthetic process
created_by: dhl
creation_date: 2011-03-11T06:48:45Z

[Term]
id: GO:2000489
name: regulation of hepatic stellate cell activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hepatic stellate cell activation." [GOC:obol]
is_a: GO:0050865 ! regulation of cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035733 ! hepatic stellate cell activation
relationship: regulates GO:0035733 ! hepatic stellate cell activation
created_by: rfoulger
creation_date: 2011-03-14T03:48:32Z

[Term]
id: GO:2000490
name: negative regulation of hepatic stellate cell activation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hepatic stellate cell activation." [GOC:obol]
is_a: GO:0050866 ! negative regulation of cell activation
is_a: GO:2000489 ! regulation of hepatic stellate cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035733 ! hepatic stellate cell activation
relationship: negatively_regulates GO:0035733 ! hepatic stellate cell activation
created_by: rfoulger
creation_date: 2011-03-14T03:49:18Z

[Term]
id: GO:2000491
name: positive regulation of hepatic stellate cell activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hepatic stellate cell activation." [GOC:obol]
is_a: GO:0050867 ! positive regulation of cell activation
is_a: GO:2000489 ! regulation of hepatic stellate cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035733 ! hepatic stellate cell activation
relationship: positively_regulates GO:0035733 ! hepatic stellate cell activation
created_by: rfoulger
creation_date: 2011-03-14T03:49:48Z

[Term]
id: GO:2000492
name: regulation of interleukin-18-mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of interleukin-18-mediated signaling pathway." [GOC:obol]
synonym: "regulation of interleukin-18-mediated signalling pathway" EXACT [GOC:obol]
is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035655 ! interleukin-18-mediated signaling pathway
relationship: regulates GO:0035655 ! interleukin-18-mediated signaling pathway
created_by: pr
creation_date: 2011-03-16T01:59:18Z

[Term]
id: GO:2000493
name: negative regulation of interleukin-18-mediated signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-18-mediated signaling pathway." [GOC:obol]
synonym: "negative regulation of interleukin-18-mediated signalling pathway" EXACT [GOC:obol]
is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway
is_a: GO:2000492 ! regulation of interleukin-18-mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035655 ! interleukin-18-mediated signaling pathway
relationship: negatively_regulates GO:0035655 ! interleukin-18-mediated signaling pathway
created_by: pr
creation_date: 2011-03-16T02:00:12Z

[Term]
id: GO:2000494
name: positive regulation of interleukin-18-mediated signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of interleukin-18-mediated signaling pathway." [GOC:obol]
synonym: "positive regulation of interleukin-18-mediated signalling pathway" EXACT [GOC:obol]
is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway
is_a: GO:2000492 ! regulation of interleukin-18-mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035655 ! interleukin-18-mediated signaling pathway
relationship: positively_regulates GO:0035655 ! interleukin-18-mediated signaling pathway
created_by: pr
creation_date: 2011-03-16T02:00:50Z

[Term]
id: GO:2000495
name: regulation of cell proliferation involved in compound eye morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis." [GOC:obol]
is_a: GO:0042127 ! regulation of cell proliferation
is_a: GO:2000027 ! regulation of organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035736 ! cell proliferation involved in compound eye morphogenesis
relationship: regulates GO:0035736 ! cell proliferation involved in compound eye morphogenesis
created_by: rfoulger
creation_date: 2011-03-18T02:18:34Z

[Term]
id: GO:2000496
name: negative regulation of cell proliferation involved in compound eye morphogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis." [GOC:obol]
is_a: GO:0008285 ! negative regulation of cell proliferation
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000495 ! regulation of cell proliferation involved in compound eye morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035736 ! cell proliferation involved in compound eye morphogenesis
relationship: negatively_regulates GO:0035736 ! cell proliferation involved in compound eye morphogenesis
created_by: rfoulger
creation_date: 2011-03-18T02:19:22Z

[Term]
id: GO:2000497
name: positive regulation of cell proliferation involved in compound eye morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis." [GOC:obol]
is_a: GO:0008284 ! positive regulation of cell proliferation
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000495 ! regulation of cell proliferation involved in compound eye morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035736 ! cell proliferation involved in compound eye morphogenesis
relationship: positively_regulates GO:0035736 ! cell proliferation involved in compound eye morphogenesis
created_by: rfoulger
creation_date: 2011-03-18T02:19:54Z

[Term]
id: GO:2000498
name: obsolete regulation of induction of apoptosis in response to chemical stimulus
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of induction of apoptosis in response to chemical stimulus." [GOC:mtg_apoptosis, GOC:obol]
comment: This term was made obsolete because it is ill-defined.
synonym: "regulation of induction of apoptosis in response to chemical stimulus" EXACT []
synonym: "regulation of induction of apoptosis in response to chemical substance" EXACT [GOC:obol]
is_obsolete: true
created_by: yaf
creation_date: 2011-03-18T02:34:53Z

[Term]
id: GO:2000499
name: obsolete negative regulation of induction of apoptosis in response to chemical stimulus
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of induction of apoptosis in response to chemical stimulus." [GOC:mtg_apoptosis, GOC:obol]
comment: This term was made obsolete because it is ill-defined.
synonym: "negative regulation of induction of apoptosis in response to chemical stimulus" EXACT []
synonym: "negative regulation of induction of apoptosis in response to chemical substance" EXACT [GOC:obol]
is_obsolete: true
created_by: yaf
creation_date: 2011-03-18T02:35:44Z

[Term]
id: GO:2000500
name: obsolete positive regulation of induction of apoptosis in response to chemical stimulus
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of induction of apoptosis in response to chemical stimulus." [GOC:mtg_apoptosis, GOC:obol]
comment: This term was made obsolete because it is ill-defined.
synonym: "positive regulation of induction of apoptosis in response to chemical stimulus" EXACT []
synonym: "positive regulation of induction of apoptosis in response to chemical substance" EXACT [GOC:obol]
is_obsolete: true
created_by: yaf
creation_date: 2011-03-18T02:36:22Z

[Term]
id: GO:2000501
name: regulation of natural killer cell chemotaxis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of natural killer cell chemotaxis." [GOC:BHF]
is_a: GO:1901623 ! regulation of lymphocyte chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035747 ! natural killer cell chemotaxis
relationship: regulates GO:0035747 ! natural killer cell chemotaxis
created_by: rfoulger
creation_date: 2011-03-21T10:09:23Z

[Term]
id: GO:2000502
name: negative regulation of natural killer cell chemotaxis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of natural killer cell chemotaxis." [GOC:BHF]
is_a: GO:1901624 ! negative regulation of lymphocyte chemotaxis
is_a: GO:2000501 ! regulation of natural killer cell chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035747 ! natural killer cell chemotaxis
relationship: negatively_regulates GO:0035747 ! natural killer cell chemotaxis
created_by: rfoulger
creation_date: 2011-03-21T10:09:32Z

[Term]
id: GO:2000503
name: positive regulation of natural killer cell chemotaxis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of natural killer cell chemotaxis." [GOC:BHF]
is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis
is_a: GO:2000403 ! positive regulation of lymphocyte migration
is_a: GO:2000501 ! regulation of natural killer cell chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035747 ! natural killer cell chemotaxis
relationship: positively_regulates GO:0035747 ! natural killer cell chemotaxis
created_by: rfoulger
creation_date: 2011-03-21T10:09:38Z

[Term]
id: GO:2000504
name: positive regulation of blood vessel remodeling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of blood vessel remodeling." [GOC:obol]
is_a: GO:0034105 ! positive regulation of tissue remodeling
is_a: GO:0060312 ! regulation of blood vessel remodeling
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001974 ! blood vessel remodeling
relationship: positively_regulates GO:0001974 ! blood vessel remodeling
created_by: pr
creation_date: 2011-03-21T10:33:20Z

[Term]
id: GO:2000505
name: regulation of energy homeostasis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of energy homeostasis." [GOC:obol, GOC:yaf]
is_a: GO:0032844 ! regulation of homeostatic process
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097009 ! energy homeostasis
relationship: regulates GO:0097009 ! energy homeostasis
created_by: pr
creation_date: 2011-03-21T10:52:44Z

[Term]
id: GO:2000506
name: negative regulation of energy homeostasis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of energy homeostasis." [GOC:obol, GOC:yaf]
is_a: GO:0032845 ! negative regulation of homeostatic process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000505 ! regulation of energy homeostasis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097009 ! energy homeostasis
relationship: negatively_regulates GO:0097009 ! energy homeostasis
created_by: pr
creation_date: 2011-03-21T10:52:50Z

[Term]
id: GO:2000507
name: positive regulation of energy homeostasis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of energy homeostasis." [GOC:obol, GOC:yaf]
is_a: GO:0032846 ! positive regulation of homeostatic process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000505 ! regulation of energy homeostasis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097009 ! energy homeostasis
relationship: positively_regulates GO:0097009 ! energy homeostasis
created_by: pr
creation_date: 2011-03-21T10:52:55Z

[Term]
id: GO:2000508
name: regulation of dendritic cell chemotaxis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dendritic cell chemotaxis." [GOC:obol]
is_a: GO:0002688 ! regulation of leukocyte chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002407 ! dendritic cell chemotaxis
relationship: regulates GO:0002407 ! dendritic cell chemotaxis
created_by: ebc
creation_date: 2011-03-22T10:21:38Z

[Term]
id: GO:2000509
name: negative regulation of dendritic cell chemotaxis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell chemotaxis." [GOC:obol]
is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis
is_a: GO:2000508 ! regulation of dendritic cell chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002407 ! dendritic cell chemotaxis
relationship: negatively_regulates GO:0002407 ! dendritic cell chemotaxis
created_by: ebc
creation_date: 2011-03-22T10:21:45Z

[Term]
id: GO:2000510
name: positive regulation of dendritic cell chemotaxis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of dendritic cell chemotaxis." [GOC:obol]
is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis
is_a: GO:2000508 ! regulation of dendritic cell chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002407 ! dendritic cell chemotaxis
relationship: positively_regulates GO:0002407 ! dendritic cell chemotaxis
created_by: ebc
creation_date: 2011-03-22T10:21:49Z

[Term]
id: GO:2000511
name: regulation of granzyme A production
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of granzyme A production." [GOC:obol]
is_a: GO:0002700 ! regulation of production of molecular mediator of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035746 ! granzyme A production
relationship: regulates GO:0035746 ! granzyme A production
created_by: ebc
creation_date: 2011-03-22T10:31:27Z

[Term]
id: GO:2000512
name: negative regulation of granzyme A production
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of granzyme A production." [GOC:obol]
is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response
is_a: GO:2000511 ! regulation of granzyme A production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035746 ! granzyme A production
relationship: negatively_regulates GO:0035746 ! granzyme A production
created_by: ebc
creation_date: 2011-03-22T10:31:32Z

[Term]
id: GO:2000513
name: positive regulation of granzyme A production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of granzyme A production." [GOC:obol]
is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response
is_a: GO:2000511 ! regulation of granzyme A production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035746 ! granzyme A production
relationship: positively_regulates GO:0035746 ! granzyme A production
created_by: ebc
creation_date: 2011-03-22T10:31:36Z

[Term]
id: GO:2000514
name: regulation of CD4-positive, alpha-beta T cell activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of CD4-positive, alpha-beta T cell activation." [GOC:obol]
is_a: GO:0046634 ! regulation of alpha-beta T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035710 ! CD4-positive, alpha-beta T cell activation
relationship: regulates GO:0035710 ! CD4-positive, alpha-beta T cell activation
created_by: ebc
creation_date: 2011-03-22T10:36:56Z

[Term]
id: GO:2000515
name: negative regulation of CD4-positive, alpha-beta T cell activation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of CD4-positive, alpha-beta T cell activation." [GOC:obol]
is_a: GO:0046636 ! negative regulation of alpha-beta T cell activation
is_a: GO:2000514 ! regulation of CD4-positive, alpha-beta T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035710 ! CD4-positive, alpha-beta T cell activation
relationship: negatively_regulates GO:0035710 ! CD4-positive, alpha-beta T cell activation
created_by: ebc
creation_date: 2011-03-22T10:37:02Z

[Term]
id: GO:2000516
name: positive regulation of CD4-positive, alpha-beta T cell activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell activation." [GOC:obol]
is_a: GO:0046635 ! positive regulation of alpha-beta T cell activation
is_a: GO:2000514 ! regulation of CD4-positive, alpha-beta T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035710 ! CD4-positive, alpha-beta T cell activation
relationship: positively_regulates GO:0035710 ! CD4-positive, alpha-beta T cell activation
created_by: ebc
creation_date: 2011-03-22T10:37:06Z

[Term]
id: GO:2000517
name: regulation of T-helper 1 cell activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of T-helper 1 cell activation." [GOC:obol]
synonym: "regulation of Th1 cell activation" EXACT [GOC:obol]
is_a: GO:2000514 ! regulation of CD4-positive, alpha-beta T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035711 ! T-helper 1 cell activation
relationship: regulates GO:0035711 ! T-helper 1 cell activation
created_by: ebc
creation_date: 2011-03-22T10:40:19Z

[Term]
id: GO:2000518
name: negative regulation of T-helper 1 cell activation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 1 cell activation." [GOC:obol]
synonym: "negative regulation of Th1 cell activation" EXACT [GOC:obol]
is_a: GO:2000515 ! negative regulation of CD4-positive, alpha-beta T cell activation
is_a: GO:2000517 ! regulation of T-helper 1 cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035711 ! T-helper 1 cell activation
relationship: negatively_regulates GO:0035711 ! T-helper 1 cell activation
created_by: ebc
creation_date: 2011-03-22T10:40:26Z

[Term]
id: GO:2000519
name: positive regulation of T-helper 1 cell activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T-helper 1 cell activation." [GOC:obol]
synonym: "positive regulation of Th1 cell activation" EXACT [GOC:obol]
is_a: GO:2000516 ! positive regulation of CD4-positive, alpha-beta T cell activation
is_a: GO:2000517 ! regulation of T-helper 1 cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035711 ! T-helper 1 cell activation
relationship: positively_regulates GO:0035711 ! T-helper 1 cell activation
created_by: ebc
creation_date: 2011-03-22T10:40:31Z

[Term]
id: GO:2000520
name: regulation of immunological synapse formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of immunological synapse formation." [GOC:obol]
synonym: "regulation of formation of immunological synapse" EXACT [GOC:obol]
is_a: GO:0051239 ! regulation of multicellular organismal process
is_a: GO:0051249 ! regulation of lymphocyte activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001771 ! immunological synapse formation
relationship: regulates GO:0001771 ! immunological synapse formation
created_by: ebc
creation_date: 2011-03-23T10:18:14Z

[Term]
id: GO:2000521
name: negative regulation of immunological synapse formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of immunological synapse formation." [GOC:obol]
synonym: "negative regulation of formation of immunological synapse" EXACT [GOC:obol]
is_a: GO:0051250 ! negative regulation of lymphocyte activation
is_a: GO:2000520 ! regulation of immunological synapse formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001771 ! immunological synapse formation
relationship: negatively_regulates GO:0001771 ! immunological synapse formation
created_by: ebc
creation_date: 2011-03-23T10:18:19Z

[Term]
id: GO:2000522
name: positive regulation of immunological synapse formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of immunological synapse formation." [GOC:obol]
synonym: "positive regulation of formation of immunological synapse" EXACT [GOC:obol]
is_a: GO:0051251 ! positive regulation of lymphocyte activation
is_a: GO:2000520 ! regulation of immunological synapse formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001771 ! immunological synapse formation
relationship: positively_regulates GO:0001771 ! immunological synapse formation
created_by: ebc
creation_date: 2011-03-23T10:18:23Z

[Term]
id: GO:2000523
name: regulation of T cell costimulation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of T cell costimulation." [GOC:obol]
synonym: "regulation of T cell co-stimulation" EXACT [GOC:obol]
synonym: "regulation of T lymphocyte costimulation" EXACT [GOC:obol]
synonym: "regulation of T-cell co-stimulation" EXACT [GOC:obol]
synonym: "regulation of T-cell costimulation" EXACT [GOC:obol]
synonym: "regulation of T-lymphocyte costimulation" EXACT [GOC:obol]
is_a: GO:0050863 ! regulation of T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031295 ! T cell costimulation
relationship: regulates GO:0031295 ! T cell costimulation
created_by: ebc
creation_date: 2011-03-23T10:23:24Z

[Term]
id: GO:2000524
name: negative regulation of T cell costimulation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of T cell costimulation." [GOC:obol]
synonym: "negative regulation of T cell co-stimulation" EXACT [GOC:obol]
synonym: "negative regulation of T lymphocyte costimulation" EXACT [GOC:obol]
synonym: "negative regulation of T-cell co-stimulation" EXACT [GOC:obol]
synonym: "negative regulation of T-cell costimulation" EXACT [GOC:obol]
synonym: "negative regulation of T-lymphocyte costimulation" EXACT [GOC:obol]
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:2000523 ! regulation of T cell costimulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0031295 ! T cell costimulation
relationship: negatively_regulates GO:0031295 ! T cell costimulation
created_by: ebc
creation_date: 2011-03-23T10:23:31Z

[Term]
id: GO:2000525
name: positive regulation of T cell costimulation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T cell costimulation." [GOC:obol]
synonym: "positive regulation of T cell co-stimulation" EXACT [GOC:obol]
synonym: "positive regulation of T lymphocyte costimulation" EXACT [GOC:obol]
synonym: "positive regulation of T-cell co-stimulation" EXACT [GOC:obol]
synonym: "positive regulation of T-cell costimulation" EXACT [GOC:obol]
synonym: "positive regulation of T-lymphocyte costimulation" EXACT [GOC:obol]
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:2000523 ! regulation of T cell costimulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0031295 ! T cell costimulation
relationship: positively_regulates GO:0031295 ! T cell costimulation
created_by: ebc
creation_date: 2011-03-23T10:23:36Z

[Term]
id: GO:2000526
name: positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation
namespace: biological_process
def: "Any positive regulation of glycoprotein biosynthetic process that is involved in immunological synapse formation." [GOC:obol]
synonym: "positive regulation of glycoprotein biosynthetic process of formation of immunological synapse" EXACT [GOC:obol]
synonym: "positive regulation of glycoprotein biosynthetic process of immunological synapse formation" EXACT [GOC:obol]
is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process
intersection_of: GO:0010560 ! positive regulation of glycoprotein biosynthetic process
intersection_of: part_of GO:0001771 ! immunological synapse formation
relationship: part_of GO:0001771 ! immunological synapse formation
created_by: ebc
creation_date: 2011-03-23T10:42:30Z

[Term]
id: GO:2000527
name: regulation of myeloid dendritic cell chemotaxis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of myeloid dendritic cell chemotaxis." [GOC:obol]
is_a: GO:2000508 ! regulation of dendritic cell chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002408 ! myeloid dendritic cell chemotaxis
relationship: regulates GO:0002408 ! myeloid dendritic cell chemotaxis
created_by: ebc
creation_date: 2011-03-23T12:18:32Z

[Term]
id: GO:2000528
name: negative regulation of myeloid dendritic cell chemotaxis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of myeloid dendritic cell chemotaxis." [GOC:obol]
is_a: GO:2000509 ! negative regulation of dendritic cell chemotaxis
is_a: GO:2000527 ! regulation of myeloid dendritic cell chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002408 ! myeloid dendritic cell chemotaxis
relationship: negatively_regulates GO:0002408 ! myeloid dendritic cell chemotaxis
created_by: ebc
creation_date: 2011-03-23T12:18:39Z

[Term]
id: GO:2000529
name: positive regulation of myeloid dendritic cell chemotaxis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of myeloid dendritic cell chemotaxis." [GOC:obol]
is_a: GO:2000510 ! positive regulation of dendritic cell chemotaxis
is_a: GO:2000527 ! regulation of myeloid dendritic cell chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002408 ! myeloid dendritic cell chemotaxis
relationship: positively_regulates GO:0002408 ! myeloid dendritic cell chemotaxis
created_by: ebc
creation_date: 2011-03-23T12:18:45Z

[Term]
id: GO:2000530
name: obsolete positive regulation of regulation of insulin secretion involved in cellular response to glucose stimulus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of regulation of insulin secretion involved in cellular response to glucose stimulus." [GOC:obol]
synonym: "positive regulation of regulation of insulin secretion in response to glucose" EXACT [GOC:obol]
synonym: "positive regulation of regulation of insulin secretion involved in cellular response to glucose stimulus" EXACT []
is_obsolete: true
created_by: yaf
creation_date: 2011-03-24T09:27:37Z

[Term]
id: GO:2000531
name: regulation of fatty acid biosynthetic process by regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the biosynthesis of fatty acids, by modulating the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:vw]
is_a: GO:0042304 ! regulation of fatty acid biosynthetic process
is_a: GO:0072364 ! regulation of cellular ketone metabolic process by regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: regulates GO:0100070 ! regulation of fatty acid biosynthetic process by transcription from RNA polymerase II promoter
relationship: regulates GO:0100070 ! regulation of fatty acid biosynthetic process by transcription from RNA polymerase II promoter
created_by: dph
creation_date: 2011-03-24T12:18:33Z

[Term]
id: GO:2000532
name: regulation of renal albumin absorption
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of renal albumin absorption." [GOC:obol, GOC:yaf]
is_a: GO:0098801 ! regulation of renal system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097018 ! renal albumin absorption
relationship: regulates GO:0097018 ! renal albumin absorption
created_by: pr
creation_date: 2011-03-24T03:28:06Z

[Term]
id: GO:2000533
name: negative regulation of renal albumin absorption
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of renal albumin absorption." [GOC:obol, GOC:yaf]
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000532 ! regulation of renal albumin absorption
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097018 ! renal albumin absorption
relationship: negatively_regulates GO:0097018 ! renal albumin absorption
created_by: pr
creation_date: 2011-03-24T03:28:11Z

[Term]
id: GO:2000534
name: positive regulation of renal albumin absorption
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of renal albumin absorption." [GOC:obol, GOC:yaf]
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000532 ! regulation of renal albumin absorption
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097018 ! renal albumin absorption
relationship: positively_regulates GO:0097018 ! renal albumin absorption
created_by: pr
creation_date: 2011-03-24T03:28:14Z

[Term]
id: GO:2000535
name: regulation of entry of bacterium into host cell
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of entry of bacterium into host cell." [GOC:obol]
synonym: "regulation of bacterial entry into host cell" EXACT [GOC:obol]
synonym: "regulation of invasion of bacteria into host cell" EXACT [GOC:obol]
is_a: GO:0040012 ! regulation of locomotion
is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035635 ! entry of bacterium into host cell
relationship: regulates GO:0035635 ! entry of bacterium into host cell
created_by: ebc
creation_date: 2011-03-28T09:52:16Z

[Term]
id: GO:2000536
name: negative regulation of entry of bacterium into host cell
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of entry of bacterium into host cell." [GOC:obol]
synonym: "negative regulation of bacterial entry into host cell" EXACT [GOC:obol]
synonym: "negative regulation of invasion of bacteria into host cell" EXACT [GOC:obol]
is_a: GO:0040013 ! negative regulation of locomotion
is_a: GO:0043901 ! negative regulation of multi-organism process
is_a: GO:2000535 ! regulation of entry of bacterium into host cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035635 ! entry of bacterium into host cell
relationship: negatively_regulates GO:0035635 ! entry of bacterium into host cell
created_by: ebc
creation_date: 2011-03-28T09:52:23Z

[Term]
id: GO:2000537
name: regulation of B cell chemotaxis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of B cell chemotaxis." [GOC:obol]
is_a: GO:1901623 ! regulation of lymphocyte chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035754 ! B cell chemotaxis
relationship: regulates GO:0035754 ! B cell chemotaxis
created_by: ebc
creation_date: 2011-03-29T09:49:25Z

[Term]
id: GO:2000538
name: positive regulation of B cell chemotaxis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of B cell chemotaxis." [GOC:obol]
is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis
is_a: GO:2000403 ! positive regulation of lymphocyte migration
is_a: GO:2000537 ! regulation of B cell chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035754 ! B cell chemotaxis
relationship: positively_regulates GO:0035754 ! B cell chemotaxis
created_by: ebc
creation_date: 2011-03-29T09:49:33Z

[Term]
id: GO:2000539
name: regulation of protein geranylgeranylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein geranylgeranylation." [GOC:obol]
synonym: "regulation of C-terminal protein geranylgeranylation" RELATED [GOC:obol]
synonym: "regulation of protein amino acid geranylgeranylation" EXACT [GOC:obol]
is_a: GO:0031399 ! regulation of protein modification process
is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0018344 ! protein geranylgeranylation
relationship: regulates GO:0018344 ! protein geranylgeranylation
created_by: tanyaberardini
creation_date: 2011-03-29T06:23:05Z

[Term]
id: GO:2000540
name: negative regulation of protein geranylgeranylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein geranylgeranylation." [GOC:obol]
synonym: "negative regulation of C-terminal protein geranylgeranylation" RELATED [GOC:obol]
synonym: "negative regulation of protein amino acid geranylgeranylation" EXACT [GOC:obol]
is_a: GO:0031400 ! negative regulation of protein modification process
is_a: GO:2000539 ! regulation of protein geranylgeranylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0018344 ! protein geranylgeranylation
relationship: negatively_regulates GO:0018344 ! protein geranylgeranylation
created_by: tanyaberardini
creation_date: 2011-03-29T06:23:11Z

[Term]
id: GO:2000541
name: positive regulation of protein geranylgeranylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein geranylgeranylation." [GOC:obol]
synonym: "positive regulation of C-terminal protein geranylgeranylation" RELATED [GOC:obol]
synonym: "positive regulation of protein amino acid geranylgeranylation" EXACT [GOC:obol]
is_a: GO:0031401 ! positive regulation of protein modification process
is_a: GO:2000539 ! regulation of protein geranylgeranylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0018344 ! protein geranylgeranylation
relationship: positively_regulates GO:0018344 ! protein geranylgeranylation
created_by: tanyaberardini
creation_date: 2011-03-29T06:23:15Z

[Term]
id: GO:2000542
name: negative regulation of gastrulation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of gastrulation." [GOC:obol]
is_a: GO:0010470 ! regulation of gastrulation
is_a: GO:0045992 ! negative regulation of embryonic development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007369 ! gastrulation
relationship: negatively_regulates GO:0007369 ! gastrulation
created_by: yaf
creation_date: 2011-04-01T04:10:08Z

[Term]
id: GO:2000543
name: positive regulation of gastrulation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of gastrulation." [GOC:obol]
is_a: GO:0010470 ! regulation of gastrulation
is_a: GO:0040019 ! positive regulation of embryonic development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007369 ! gastrulation
relationship: positively_regulates GO:0007369 ! gastrulation
created_by: yaf
creation_date: 2011-04-01T04:10:15Z

[Term]
id: GO:2000544
name: regulation of endothelial cell chemotaxis to fibroblast growth factor
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endothelial cell chemotaxis to fibroblast growth factor." [GOC:obol]
is_a: GO:1904847 ! regulation of cell chemotaxis to fibroblast growth factor
is_a: GO:2001026 ! regulation of endothelial cell chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035768 ! endothelial cell chemotaxis to fibroblast growth factor
relationship: regulates GO:0035768 ! endothelial cell chemotaxis to fibroblast growth factor
created_by: ebc
creation_date: 2011-04-03T07:14:04Z

[Term]
id: GO:2000545
name: negative regulation of endothelial cell chemotaxis to fibroblast growth factor
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell chemotaxis to fibroblast growth factor." [GOC:obol]
is_a: GO:1904848 ! negative regulation of cell chemotaxis to fibroblast growth factor
is_a: GO:2000544 ! regulation of endothelial cell chemotaxis to fibroblast growth factor
is_a: GO:2001027 ! negative regulation of endothelial cell chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035768 ! endothelial cell chemotaxis to fibroblast growth factor
relationship: negatively_regulates GO:0035768 ! endothelial cell chemotaxis to fibroblast growth factor
created_by: ebc
creation_date: 2011-04-03T07:14:11Z

[Term]
id: GO:2000546
name: positive regulation of endothelial cell chemotaxis to fibroblast growth factor
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis to fibroblast growth factor." [GOC:obol]
is_a: GO:1904849 ! positive regulation of cell chemotaxis to fibroblast growth factor
is_a: GO:2000544 ! regulation of endothelial cell chemotaxis to fibroblast growth factor
is_a: GO:2001028 ! positive regulation of endothelial cell chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035768 ! endothelial cell chemotaxis to fibroblast growth factor
relationship: positively_regulates GO:0035768 ! endothelial cell chemotaxis to fibroblast growth factor
created_by: ebc
creation_date: 2011-04-03T07:17:27Z

[Term]
id: GO:2000547
name: regulation of dendritic cell dendrite assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dendritic cell dendrite assembly." [GOC:obol]
synonym: "regulation of dendritic extension" RELATED [GOC:obol]
is_a: GO:0060491 ! regulation of cell projection assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097026 ! dendritic cell dendrite assembly
relationship: regulates GO:0097026 ! dendritic cell dendrite assembly
created_by: ebc
creation_date: 2011-04-03T07:21:55Z

[Term]
id: GO:2000548
name: negative regulation of dendritic cell dendrite assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell dendrite assembly." [GOC:obol]
synonym: "negative regulation of dendritic extension" RELATED [GOC:obol]
is_a: GO:0031345 ! negative regulation of cell projection organization
is_a: GO:2000547 ! regulation of dendritic cell dendrite assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097026 ! dendritic cell dendrite assembly
relationship: negatively_regulates GO:0097026 ! dendritic cell dendrite assembly
created_by: ebc
creation_date: 2011-04-03T07:22:01Z

[Term]
id: GO:2000549
name: positive regulation of dendritic cell dendrite assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of dendritic cell dendrite assembly." [GOC:obol]
synonym: "positive regulation of dendritic extension" RELATED [GOC:obol]
is_a: GO:0031346 ! positive regulation of cell projection organization
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:2000547 ! regulation of dendritic cell dendrite assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097026 ! dendritic cell dendrite assembly
relationship: positively_regulates GO:0097026 ! dendritic cell dendrite assembly
created_by: ebc
creation_date: 2011-04-03T07:22:06Z

[Term]
id: GO:2000550
name: negative regulation of B cell chemotaxis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of B cell chemotaxis." [GOC:obol]
is_a: GO:1901624 ! negative regulation of lymphocyte chemotaxis
is_a: GO:2000537 ! regulation of B cell chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035754 ! B cell chemotaxis
relationship: negatively_regulates GO:0035754 ! B cell chemotaxis
created_by: ebc
creation_date: 2011-04-03T07:25:59Z

[Term]
id: GO:2000551
name: regulation of T-helper 2 cell cytokine production
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of T-helper 2 cell cytokine production." [GOC:obol]
synonym: "regulation of Th2 cell cytokine production" EXACT [GOC:obol]
is_a: GO:0002724 ! regulation of T cell cytokine production
is_a: GO:0002828 ! regulation of type 2 immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035745 ! T-helper 2 cell cytokine production
relationship: regulates GO:0035745 ! T-helper 2 cell cytokine production
created_by: ebc
creation_date: 2011-04-03T07:32:47Z

[Term]
id: GO:2000552
name: negative regulation of T-helper 2 cell cytokine production
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 2 cell cytokine production." [GOC:obol]
synonym: "negative regulation of Th2 cell cytokine production" EXACT [GOC:obol]
is_a: GO:0002725 ! negative regulation of T cell cytokine production
is_a: GO:0002829 ! negative regulation of type 2 immune response
is_a: GO:2000551 ! regulation of T-helper 2 cell cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035745 ! T-helper 2 cell cytokine production
relationship: negatively_regulates GO:0035745 ! T-helper 2 cell cytokine production
created_by: ebc
creation_date: 2011-04-03T07:32:54Z

[Term]
id: GO:2000553
name: positive regulation of T-helper 2 cell cytokine production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T-helper 2 cell cytokine production." [GOC:obol]
synonym: "positive regulation of Th2 cell cytokine production" EXACT [GOC:obol]
is_a: GO:0002726 ! positive regulation of T cell cytokine production
is_a: GO:0002830 ! positive regulation of type 2 immune response
is_a: GO:2000551 ! regulation of T-helper 2 cell cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035745 ! T-helper 2 cell cytokine production
relationship: positively_regulates GO:0035745 ! T-helper 2 cell cytokine production
created_by: ebc
creation_date: 2011-04-03T07:32:58Z

[Term]
id: GO:2000554
name: regulation of T-helper 1 cell cytokine production
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of T-helper 1 cell cytokine production." [GOC:obol]
synonym: "regulation of Th1 cell cytokine production" EXACT [GOC:obol]
is_a: GO:0002724 ! regulation of T cell cytokine production
is_a: GO:0002825 ! regulation of T-helper 1 type immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035744 ! T-helper 1 cell cytokine production
relationship: regulates GO:0035744 ! T-helper 1 cell cytokine production
created_by: ebc
creation_date: 2011-04-03T07:35:43Z

[Term]
id: GO:2000555
name: negative regulation of T-helper 1 cell cytokine production
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 1 cell cytokine production." [GOC:obol]
synonym: "negative regulation of Th1 cell cytokine production" EXACT [GOC:obol]
is_a: GO:0002725 ! negative regulation of T cell cytokine production
is_a: GO:0002826 ! negative regulation of T-helper 1 type immune response
is_a: GO:2000554 ! regulation of T-helper 1 cell cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035744 ! T-helper 1 cell cytokine production
relationship: negatively_regulates GO:0035744 ! T-helper 1 cell cytokine production
created_by: ebc
creation_date: 2011-04-03T07:35:51Z

[Term]
id: GO:2000556
name: positive regulation of T-helper 1 cell cytokine production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T-helper 1 cell cytokine production." [GOC:obol]
synonym: "positive regulation of Th1 cell cytokine production" EXACT [GOC:obol]
is_a: GO:0002726 ! positive regulation of T cell cytokine production
is_a: GO:0002827 ! positive regulation of T-helper 1 type immune response
is_a: GO:2000554 ! regulation of T-helper 1 cell cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035744 ! T-helper 1 cell cytokine production
relationship: positively_regulates GO:0035744 ! T-helper 1 cell cytokine production
created_by: ebc
creation_date: 2011-04-03T07:35:56Z

[Term]
id: GO:2000557
name: regulation of immunoglobulin production in mucosal tissue
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of immunoglobulin production in mucosal tissue." [GOC:obol]
synonym: "regulation of antibody production in mucosal tissue" EXACT [GOC:obol]
is_a: GO:0002637 ! regulation of immunoglobulin production
is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002426 ! immunoglobulin production in mucosal tissue
relationship: regulates GO:0002426 ! immunoglobulin production in mucosal tissue
created_by: ebc
creation_date: 2011-04-03T07:52:09Z

[Term]
id: GO:2000558
name: positive regulation of immunoglobulin production in mucosal tissue
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of immunoglobulin production in mucosal tissue." [GOC:obol]
synonym: "positive regulation of antibody production in mucosal tissue" EXACT [GOC:obol]
is_a: GO:0002639 ! positive regulation of immunoglobulin production
is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response
is_a: GO:2000557 ! regulation of immunoglobulin production in mucosal tissue
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002426 ! immunoglobulin production in mucosal tissue
relationship: positively_regulates GO:0002426 ! immunoglobulin production in mucosal tissue
created_by: ebc
creation_date: 2011-04-03T07:52:17Z

[Term]
id: GO:2000559
name: regulation of CD24 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of CD24 biosynthetic process." [GOC:obol]
synonym: "regulation of CD24 anabolism" EXACT [GOC:obol]
synonym: "regulation of CD24 biosynthesis" EXACT [GOC:obol]
synonym: "regulation of CD24 formation" EXACT [GOC:obol]
synonym: "regulation of CD24 synthesis" EXACT [GOC:obol]
is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035724 ! CD24 biosynthetic process
relationship: regulates GO:0035724 ! CD24 biosynthetic process
created_by: ebc
creation_date: 2011-04-03T08:56:56Z

[Term]
id: GO:2000560
name: positive regulation of CD24 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of CD24 biosynthetic process." [GOC:obol]
synonym: "positive regulation of CD24 anabolism" EXACT [GOC:obol]
synonym: "positive regulation of CD24 biosynthesis" EXACT [GOC:obol]
synonym: "positive regulation of CD24 formation" EXACT [GOC:obol]
synonym: "positive regulation of CD24 synthesis" EXACT [GOC:obol]
is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process
is_a: GO:2000559 ! regulation of CD24 biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035724 ! CD24 biosynthetic process
relationship: positively_regulates GO:0035724 ! CD24 biosynthetic process
created_by: ebc
creation_date: 2011-04-03T08:57:02Z

[Term]
id: GO:2000561
name: regulation of CD4-positive, alpha-beta T cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of CD4-positive, alpha-beta T cell proliferation." [GOC:obol]
is_a: GO:0046640 ! regulation of alpha-beta T cell proliferation
is_a: GO:2000514 ! regulation of CD4-positive, alpha-beta T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035739 ! CD4-positive, alpha-beta T cell proliferation
relationship: regulates GO:0035739 ! CD4-positive, alpha-beta T cell proliferation
created_by: ebc
creation_date: 2011-04-03T09:01:04Z

[Term]
id: GO:2000562
name: negative regulation of CD4-positive, alpha-beta T cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of CD4-positive, alpha-beta T cell proliferation." [GOC:obol]
is_a: GO:0046642 ! negative regulation of alpha-beta T cell proliferation
is_a: GO:2000515 ! negative regulation of CD4-positive, alpha-beta T cell activation
is_a: GO:2000561 ! regulation of CD4-positive, alpha-beta T cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035739 ! CD4-positive, alpha-beta T cell proliferation
relationship: negatively_regulates GO:0035739 ! CD4-positive, alpha-beta T cell proliferation
created_by: ebc
creation_date: 2011-04-03T09:01:11Z

[Term]
id: GO:2000563
name: positive regulation of CD4-positive, alpha-beta T cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell proliferation." [GOC:obol]
is_a: GO:0046641 ! positive regulation of alpha-beta T cell proliferation
is_a: GO:2000516 ! positive regulation of CD4-positive, alpha-beta T cell activation
is_a: GO:2000561 ! regulation of CD4-positive, alpha-beta T cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035739 ! CD4-positive, alpha-beta T cell proliferation
relationship: positively_regulates GO:0035739 ! CD4-positive, alpha-beta T cell proliferation
created_by: ebc
creation_date: 2011-04-03T09:01:15Z

[Term]
id: GO:2000564
name: regulation of CD8-positive, alpha-beta T cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of CD8-positive, alpha-beta T cell proliferation." [GOC:obol]
is_a: GO:0046640 ! regulation of alpha-beta T cell proliferation
is_a: GO:2001185 ! regulation of CD8-positive, alpha-beta T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035740 ! CD8-positive, alpha-beta T cell proliferation
relationship: regulates GO:0035740 ! CD8-positive, alpha-beta T cell proliferation
created_by: ebc
creation_date: 2011-04-03T09:03:13Z

[Term]
id: GO:2000565
name: negative regulation of CD8-positive, alpha-beta T cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of CD8-positive, alpha-beta T cell proliferation." [GOC:obol]
is_a: GO:0046642 ! negative regulation of alpha-beta T cell proliferation
is_a: GO:2000564 ! regulation of CD8-positive, alpha-beta T cell proliferation
is_a: GO:2001186 ! negative regulation of CD8-positive, alpha-beta T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035740 ! CD8-positive, alpha-beta T cell proliferation
relationship: negatively_regulates GO:0035740 ! CD8-positive, alpha-beta T cell proliferation
created_by: ebc
creation_date: 2011-04-03T09:03:19Z

[Term]
id: GO:2000566
name: positive regulation of CD8-positive, alpha-beta T cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell proliferation." [GOC:obol]
is_a: GO:0046641 ! positive regulation of alpha-beta T cell proliferation
is_a: GO:2000564 ! regulation of CD8-positive, alpha-beta T cell proliferation
is_a: GO:2001187 ! positive regulation of CD8-positive, alpha-beta T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035740 ! CD8-positive, alpha-beta T cell proliferation
relationship: positively_regulates GO:0035740 ! CD8-positive, alpha-beta T cell proliferation
created_by: ebc
creation_date: 2011-04-03T09:03:24Z

[Term]
id: GO:2000567
name: regulation of memory T cell activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of memory T cell activation." [GOC:obol]
is_a: GO:0050863 ! regulation of T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035709 ! memory T cell activation
relationship: regulates GO:0035709 ! memory T cell activation
created_by: ebc
creation_date: 2011-04-03T09:10:06Z

[Term]
id: GO:2000568
name: positive regulation of memory T cell activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of memory T cell activation." [GOC:obol]
is_a: GO:0050870 ! positive regulation of T cell activation
is_a: GO:2000567 ! regulation of memory T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035709 ! memory T cell activation
relationship: positively_regulates GO:0035709 ! memory T cell activation
created_by: ebc
creation_date: 2011-04-03T09:10:12Z

[Term]
id: GO:2000569
name: regulation of T-helper 2 cell activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of T-helper 2 cell activation." [GOC:obol]
synonym: "regulation of Th2 cell activation" EXACT [GOC:obol]
is_a: GO:2000514 ! regulation of CD4-positive, alpha-beta T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035712 ! T-helper 2 cell activation
relationship: regulates GO:0035712 ! T-helper 2 cell activation
created_by: ebc
creation_date: 2011-04-03T09:14:53Z

[Term]
id: GO:2000570
name: positive regulation of T-helper 2 cell activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T-helper 2 cell activation." [GOC:obol]
synonym: "positive regulation of Th2 cell activation" EXACT [GOC:obol]
is_a: GO:2000516 ! positive regulation of CD4-positive, alpha-beta T cell activation
is_a: GO:2000569 ! regulation of T-helper 2 cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035712 ! T-helper 2 cell activation
relationship: positively_regulates GO:0035712 ! T-helper 2 cell activation
created_by: ebc
creation_date: 2011-04-03T09:14:59Z

[Term]
id: GO:2000571
name: regulation of interleukin-4-dependent isotype switching to IgE isotypes
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of interleukin-4-dependent isotype switching to IgE isotypes." [GOC:obol]
synonym: "regulation of IL-4-dependent isotype switching to IgE isotypes" EXACT [GOC:obol]
is_a: GO:0048293 ! regulation of isotype switching to IgE isotypes
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035708 ! interleukin-4-dependent isotype switching to IgE isotypes
relationship: regulates GO:0035708 ! interleukin-4-dependent isotype switching to IgE isotypes
created_by: ebc
creation_date: 2011-04-03T09:20:11Z

[Term]
id: GO:2000572
name: positive regulation of interleukin-4-dependent isotype switching to IgE isotypes
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of interleukin-4-dependent isotype switching to IgE isotypes." [GOC:obol]
synonym: "positive regulation of IL-4-dependent isotype switching to IgE isotypes" EXACT [GOC:obol]
is_a: GO:0048295 ! positive regulation of isotype switching to IgE isotypes
is_a: GO:2000571 ! regulation of interleukin-4-dependent isotype switching to IgE isotypes
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035708 ! interleukin-4-dependent isotype switching to IgE isotypes
relationship: positively_regulates GO:0035708 ! interleukin-4-dependent isotype switching to IgE isotypes
created_by: ebc
creation_date: 2011-04-03T09:20:18Z

[Term]
id: GO:2000573
name: positive regulation of DNA biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process." [GOC:obol]
synonym: "positive regulation of DNA anabolism" EXACT [GOC:obol]
synonym: "positive regulation of DNA biosynthesis" EXACT [GOC:obol]
synonym: "positive regulation of DNA formation" EXACT [GOC:obol]
synonym: "positive regulation of DNA synthesis" EXACT [GOC:obol]
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0051054 ! positive regulation of DNA metabolic process
is_a: GO:2000278 ! regulation of DNA biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071897 ! DNA biosynthetic process
relationship: positively_regulates GO:0071897 ! DNA biosynthetic process
created_by: yaf
creation_date: 2011-04-04T10:01:20Z

[Term]
id: GO:2000574
name: regulation of microtubule motor activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of microtubule motor activity." [GOC:kmv]
synonym: "regulation of axonemal motor activity" RELATED [GOC:obol]
synonym: "regulation of dynein" RELATED [GOC:obol]
synonym: "regulation of dynein ATPase activity" RELATED [GOC:obol]
synonym: "regulation of kinesin" RELATED [GOC:obol]
synonym: "regulation of kinesin motor activity" RELATED [GOC:obol]
synonym: "regulation of kinetochore motor activity" RELATED [GOC:obol]
is_a: GO:0051336 ! regulation of hydrolase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003777 ! microtubule motor activity
relationship: regulates GO:0003777 ! microtubule motor activity
created_by: rfoulger
creation_date: 2011-04-05T08:36:44Z

[Term]
id: GO:2000575
name: negative regulation of microtubule motor activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of microtubule motor activity." [GOC:kmv]
synonym: "negative regulation of axonemal motor activity" RELATED [GOC:obol]
synonym: "negative regulation of dynein" RELATED [GOC:obol]
synonym: "negative regulation of dynein ATPase activity" RELATED [GOC:obol]
synonym: "negative regulation of kinesin" RELATED [GOC:obol]
synonym: "negative regulation of kinesin motor activity" RELATED [GOC:obol]
synonym: "negative regulation of kinetochore motor activity" RELATED [GOC:obol]
is_a: GO:0051346 ! negative regulation of hydrolase activity
is_a: GO:2000574 ! regulation of microtubule motor activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003777 ! microtubule motor activity
relationship: negatively_regulates GO:0003777 ! microtubule motor activity
created_by: rfoulger
creation_date: 2011-04-05T08:36:48Z

[Term]
id: GO:2000576
name: positive regulation of microtubule motor activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of microtubule motor activity." [GOC:kmv]
synonym: "positive regulation of axonemal motor activity" RELATED [GOC:obol]
synonym: "positive regulation of dynein" RELATED [GOC:obol]
synonym: "positive regulation of dynein ATPase activity" RELATED [GOC:obol]
synonym: "positive regulation of kinesin" RELATED [GOC:obol]
synonym: "positive regulation of kinesin motor activity" RELATED [GOC:obol]
synonym: "positive regulation of kinetochore motor activity" RELATED [GOC:obol]
is_a: GO:0051345 ! positive regulation of hydrolase activity
is_a: GO:2000574 ! regulation of microtubule motor activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003777 ! microtubule motor activity
relationship: positively_regulates GO:0003777 ! microtubule motor activity
created_by: rfoulger
creation_date: 2011-04-05T08:36:51Z

[Term]
id: GO:2000577
name: regulation of ATP-dependent microtubule motor activity, minus-end-directed
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ATP-dependent microtubule motor activity, minus-end-directed." [GOC:kmv, GOC:vw]
synonym: "regulation of kinesin ATP phosphohydrolase (minus-end-directed)" EXACT [GOC:obol]
synonym: "regulation of minus-end-directed kinesin ATPase activity" RELATED [GOC:obol]
synonym: "regulation of minus-end-directed microtubule motor activity" BROAD []
is_a: GO:0043462 ! regulation of ATPase activity
is_a: GO:2000574 ! regulation of microtubule motor activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008569 ! ATP-dependent microtubule motor activity, minus-end-directed
relationship: regulates GO:0008569 ! ATP-dependent microtubule motor activity, minus-end-directed
created_by: rfoulger
creation_date: 2011-04-05T08:37:52Z

[Term]
id: GO:2000578
name: negative regulation of ATP-dependent microtubule motor activity, minus-end-directed
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ATP-dependent microtubule motor activity, minus-end-directed." [GOC:kmv, GOC:vw]
synonym: "negative regulation of kinesin ATP phosphohydrolase (minus-end-directed)" EXACT [GOC:obol]
synonym: "negative regulation of minus-end-directed kinesin ATPase activity" EXACT [GOC:obol]
synonym: "negative regulation of minus-end-directed microtubule motor activity" BROAD []
is_a: GO:0032780 ! negative regulation of ATPase activity
is_a: GO:2000575 ! negative regulation of microtubule motor activity
is_a: GO:2000577 ! regulation of ATP-dependent microtubule motor activity, minus-end-directed
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008569 ! ATP-dependent microtubule motor activity, minus-end-directed
relationship: negatively_regulates GO:0008569 ! ATP-dependent microtubule motor activity, minus-end-directed
created_by: rfoulger
creation_date: 2011-04-05T08:37:57Z

[Term]
id: GO:2000579
name: positive regulation of ATP-dependent microtubule motor activity, minus-end-directed
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ATP-dependent microtubule motor activity, minus-end-directed." [GOC:kmv, GOC:vw]
synonym: "positive regulation of kinesin ATP phosphohydrolase (minus-end-directed)" EXACT [GOC:obol]
synonym: "positive regulation of minus-end-directed kinesin ATPase activity" EXACT [GOC:obol]
synonym: "positive regulation of minus-end-directed microtubule motor activity" BROAD []
is_a: GO:0032781 ! positive regulation of ATPase activity
is_a: GO:2000576 ! positive regulation of microtubule motor activity
is_a: GO:2000577 ! regulation of ATP-dependent microtubule motor activity, minus-end-directed
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008569 ! ATP-dependent microtubule motor activity, minus-end-directed
relationship: positively_regulates GO:0008569 ! ATP-dependent microtubule motor activity, minus-end-directed
created_by: rfoulger
creation_date: 2011-04-05T08:38:01Z

[Term]
id: GO:2000580
name: regulation of ATP-dependent microtubule motor activity, plus-end-directed
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ATP-dependent microtubule motor activity, plus-end-directed." [GOC:kmv, GOC:vw]
synonym: "regulation of kinesin activity" RELATED [GOC:obol]
synonym: "regulation of kinesin ATP phosphohydrolase (plus-end-directed)" EXACT [GOC:obol]
synonym: "regulation of plus-end-directed kinesin ATPase activity" EXACT [GOC:obol]
synonym: "regulation of plus-end-directed microtubule motor activity" BROAD []
is_a: GO:0043462 ! regulation of ATPase activity
is_a: GO:2000574 ! regulation of microtubule motor activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008574 ! ATP-dependent microtubule motor activity, plus-end-directed
relationship: regulates GO:0008574 ! ATP-dependent microtubule motor activity, plus-end-directed
created_by: rfoulger
creation_date: 2011-04-05T08:39:43Z

[Term]
id: GO:2000581
name: negative regulation of ATP-dependent microtubule motor activity, plus-end-directed
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ATP-dependent microtubule motor activity, plus-end-directed." [GOC:kmv, GOC:vw]
synonym: "negative regulation of kinesin activity" RELATED [GOC:obol]
synonym: "negative regulation of kinesin ATP phosphohydrolase (plus-end-directed)" EXACT [GOC:obol]
synonym: "negative regulation of plus-end-directed kinesin ATPase activity" EXACT [GOC:obol]
synonym: "negative regulation of plus-end-directed microtubule motor activity" BROAD []
is_a: GO:0032780 ! negative regulation of ATPase activity
is_a: GO:2000575 ! negative regulation of microtubule motor activity
is_a: GO:2000580 ! regulation of ATP-dependent microtubule motor activity, plus-end-directed
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008574 ! ATP-dependent microtubule motor activity, plus-end-directed
relationship: negatively_regulates GO:0008574 ! ATP-dependent microtubule motor activity, plus-end-directed
created_by: rfoulger
creation_date: 2011-04-05T08:39:49Z

[Term]
id: GO:2000582
name: positive regulation of ATP-dependent microtubule motor activity, plus-end-directed
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ATP-dependent microtubule motor activity, plus-end-directed." [GOC:kmv, GOC:vw]
synonym: "positive regulation of kinesin activity" RELATED [GOC:obol]
synonym: "positive regulation of kinesin ATP phosphohydrolase (plus-end-directed)" EXACT [GOC:obol]
synonym: "positive regulation of plus-end-directed kinesin ATPase activity" EXACT [GOC:obol]
synonym: "positive regulation of plus-end-directed microtubule motor activity" BROAD []
is_a: GO:0032781 ! positive regulation of ATPase activity
is_a: GO:2000576 ! positive regulation of microtubule motor activity
is_a: GO:2000580 ! regulation of ATP-dependent microtubule motor activity, plus-end-directed
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008574 ! ATP-dependent microtubule motor activity, plus-end-directed
relationship: positively_regulates GO:0008574 ! ATP-dependent microtubule motor activity, plus-end-directed
created_by: rfoulger
creation_date: 2011-04-05T08:39:52Z

[Term]
id: GO:2000583
name: regulation of platelet-derived growth factor receptor-alpha signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of platelet-derived growth factor receptor-alpha signaling pathway." [GOC:obol]
synonym: "regulation of alphaPDGF receptor signaling pathway" EXACT [GOC:obol]
synonym: "regulation of PDGF receptor-alpha signaling pathway" EXACT [GOC:obol]
synonym: "regulation of PDGFR-alpha signaling pathway" RELATED [GOC:obol]
synonym: "regulation of platelet-derived growth factor receptor-alpha signalling pathway" EXACT [GOC:mah]
is_a: GO:0010640 ! regulation of platelet-derived growth factor receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035790 ! platelet-derived growth factor receptor-alpha signaling pathway
relationship: regulates GO:0035790 ! platelet-derived growth factor receptor-alpha signaling pathway
created_by: rfoulger
creation_date: 2011-04-07T03:26:25Z

[Term]
id: GO:2000584
name: negative regulation of platelet-derived growth factor receptor-alpha signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of platelet-derived growth factor receptor-alpha signaling pathway." [GOC:obol, GOC:yaf]
synonym: "negative regulation of alphaPDGF receptor signaling pathway" EXACT [GOC:obol]
synonym: "negative regulation of PDGF receptor-alpha signaling pathway" EXACT [GOC:obol]
synonym: "negative regulation of PDGFR-alpha signaling pathway" RELATED [GOC:obol]
synonym: "negative regulation of platelet-derived growth factor receptor-alpha signalling pathway" EXACT [GOC:mah]
is_a: GO:0010642 ! negative regulation of platelet-derived growth factor receptor signaling pathway
is_a: GO:2000583 ! regulation of platelet-derived growth factor receptor-alpha signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035790 ! platelet-derived growth factor receptor-alpha signaling pathway
relationship: negatively_regulates GO:0035790 ! platelet-derived growth factor receptor-alpha signaling pathway
created_by: rfoulger
creation_date: 2011-04-07T03:26:31Z

[Term]
id: GO:2000585
name: positive regulation of platelet-derived growth factor receptor-alpha signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of platelet-derived growth factor receptor-alpha signaling pathway." [GOC:obol]
synonym: "positive regulation of alphaPDGF receptor signaling pathway" EXACT [GOC:obol]
synonym: "positive regulation of PDGF receptor-alpha signaling pathway" EXACT [GOC:obol]
synonym: "positive regulation of PDGFR-alpha signaling pathway" RELATED [GOC:obol]
synonym: "positive regulation of platelet-derived growth factor receptor-alpha signalling pathway" EXACT [GOC:mah]
is_a: GO:0010641 ! positive regulation of platelet-derived growth factor receptor signaling pathway
is_a: GO:2000583 ! regulation of platelet-derived growth factor receptor-alpha signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035790 ! platelet-derived growth factor receptor-alpha signaling pathway
relationship: positively_regulates GO:0035790 ! platelet-derived growth factor receptor-alpha signaling pathway
created_by: rfoulger
creation_date: 2011-04-07T03:26:35Z

[Term]
id: GO:2000586
name: regulation of platelet-derived growth factor receptor-beta signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of platelet-derived growth factor receptor-beta signaling pathway." [GOC:obol]
synonym: "regulation of betaPDGF receptor signaling pathway" EXACT [GOC:obol]
synonym: "regulation of PDGF receptor-beta signaling pathway" EXACT [GOC:obol]
synonym: "regulation of PDGFR-beta signaling pathway" EXACT [GOC:obol]
synonym: "regulation of platelet-derived growth factor receptor-beta signalling pathway" EXACT [GOC:mah]
is_a: GO:0010640 ! regulation of platelet-derived growth factor receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035791 ! platelet-derived growth factor receptor-beta signaling pathway
relationship: regulates GO:0035791 ! platelet-derived growth factor receptor-beta signaling pathway
created_by: rfoulger
creation_date: 2011-04-07T03:27:48Z

[Term]
id: GO:2000587
name: negative regulation of platelet-derived growth factor receptor-beta signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of platelet-derived growth factor receptor-beta signaling pathway." [GOC:obol]
synonym: "negative regulation of betaPDGF receptor signaling pathway" EXACT [GOC:obol]
synonym: "negative regulation of PDGF receptor-beta signaling pathway" EXACT [GOC:obol]
synonym: "negative regulation of PDGFR-beta signaling pathway" EXACT [GOC:obol]
synonym: "negative regulation of platelet-derived growth factor receptor-beta signalling pathway" EXACT [GOC:mah]
is_a: GO:0010642 ! negative regulation of platelet-derived growth factor receptor signaling pathway
is_a: GO:2000586 ! regulation of platelet-derived growth factor receptor-beta signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035791 ! platelet-derived growth factor receptor-beta signaling pathway
relationship: negatively_regulates GO:0035791 ! platelet-derived growth factor receptor-beta signaling pathway
created_by: rfoulger
creation_date: 2011-04-07T03:27:54Z

[Term]
id: GO:2000588
name: positive regulation of platelet-derived growth factor receptor-beta signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of platelet-derived growth factor receptor-beta signaling pathway." [GOC:obol]
synonym: "positive regulation of betaPDGF receptor signaling pathway" EXACT [GOC:obol]
synonym: "positive regulation of PDGF receptor-beta signaling pathway" EXACT [GOC:obol]
synonym: "positive regulation of PDGFR-beta signaling pathway" EXACT [GOC:obol]
synonym: "positive regulation of platelet-derived growth factor receptor-beta signalling pathway" EXACT [GOC:mah]
is_a: GO:0010641 ! positive regulation of platelet-derived growth factor receptor signaling pathway
is_a: GO:2000586 ! regulation of platelet-derived growth factor receptor-beta signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035791 ! platelet-derived growth factor receptor-beta signaling pathway
relationship: positively_regulates GO:0035791 ! platelet-derived growth factor receptor-beta signaling pathway
created_by: rfoulger
creation_date: 2011-04-07T03:27:58Z

[Term]
id: GO:2000589
name: regulation of metanephric mesenchymal cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of metanephric mesenchymal cell migration." [GOC:obol]
synonym: "regulation of metanephric mesenchyme chemotaxis" RELATED [GOC:obol]
is_a: GO:0030334 ! regulation of cell migration
is_a: GO:0072215 ! regulation of metanephros development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035789 ! metanephric mesenchymal cell migration
relationship: regulates GO:0035789 ! metanephric mesenchymal cell migration
created_by: rfoulger
creation_date: 2011-04-07T03:29:43Z

[Term]
id: GO:2000590
name: negative regulation of metanephric mesenchymal cell migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of metanephric mesenchymal cell migration." [GOC:obol]
synonym: "negative regulation of metanephric mesenchyme chemotaxis" RELATED [GOC:obol]
is_a: GO:0030336 ! negative regulation of cell migration
is_a: GO:0072217 ! negative regulation of metanephros development
is_a: GO:2000589 ! regulation of metanephric mesenchymal cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035789 ! metanephric mesenchymal cell migration
relationship: negatively_regulates GO:0035789 ! metanephric mesenchymal cell migration
created_by: rfoulger
creation_date: 2011-04-07T03:29:49Z

[Term]
id: GO:2000591
name: positive regulation of metanephric mesenchymal cell migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of metanephric mesenchymal cell migration." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf]
synonym: "positive regulation of metanephric mesenchyme chemotaxis" RELATED [GOC:obol]
is_a: GO:0030335 ! positive regulation of cell migration
is_a: GO:0072216 ! positive regulation of metanephros development
is_a: GO:2000589 ! regulation of metanephric mesenchymal cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035789 ! metanephric mesenchymal cell migration
relationship: positively_regulates GO:0035789 ! metanephric mesenchymal cell migration
created_by: rfoulger
creation_date: 2011-04-07T03:29:53Z

[Term]
id: GO:2000592
name: regulation of metanephric DCT cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of metanephric DCT cell differentiation." [GOC:obol]
synonym: "regulation of metanephric distal convoluted tubule cell differentiation" EXACT [GOC:obol]
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:0072215 ! regulation of metanephros development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072240 ! metanephric DCT cell differentiation
relationship: regulates GO:0072240 ! metanephric DCT cell differentiation
created_by: yaf
creation_date: 2011-04-11T01:40:33Z

[Term]
id: GO:2000593
name: negative regulation of metanephric DCT cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of metanephric DCT cell differentiation." [GOC:obol]
synonym: "negative regulation of metanephric distal convoluted tubule cell differentiation" EXACT [GOC:obol]
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0072217 ! negative regulation of metanephros development
is_a: GO:2000592 ! regulation of metanephric DCT cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072240 ! metanephric DCT cell differentiation
relationship: negatively_regulates GO:0072240 ! metanephric DCT cell differentiation
created_by: yaf
creation_date: 2011-04-11T01:40:38Z

[Term]
id: GO:2000594
name: positive regulation of metanephric DCT cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of metanephric DCT cell differentiation." [GOC:obol]
synonym: "positive regulation of metanephric distal convoluted tubule cell differentiation" EXACT [GOC:obol]
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0072216 ! positive regulation of metanephros development
is_a: GO:2000592 ! regulation of metanephric DCT cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072240 ! metanephric DCT cell differentiation
relationship: positively_regulates GO:0072240 ! metanephric DCT cell differentiation
created_by: yaf
creation_date: 2011-04-11T01:40:41Z

[Term]
id: GO:2000595
name: regulation of optic nerve formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of optic nerve formation." [GOC:obol]
synonym: "regulation of CN II biosynthesis" RELATED [GOC:obol]
synonym: "regulation of CN II formation" RELATED [GOC:obol]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0051960 ! regulation of nervous system development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0021634 ! optic nerve formation
relationship: regulates GO:0021634 ! optic nerve formation
created_by: yaf
creation_date: 2011-04-11T03:41:30Z

[Term]
id: GO:2000596
name: negative regulation of optic nerve formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of optic nerve formation." [GOC:obol]
synonym: "negative regulation of CN II biosynthesis" RELATED [GOC:obol]
synonym: "negative regulation of CN II formation" RELATED [GOC:obol]
is_a: GO:0051961 ! negative regulation of nervous system development
is_a: GO:2000595 ! regulation of optic nerve formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0021634 ! optic nerve formation
relationship: negatively_regulates GO:0021634 ! optic nerve formation
created_by: yaf
creation_date: 2011-04-11T03:41:35Z

[Term]
id: GO:2000597
name: positive regulation of optic nerve formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of optic nerve formation." [GOC:obol]
synonym: "positive regulation of CN II biosynthesis" RELATED [GOC:obol]
synonym: "positive regulation of CN II formation" RELATED [GOC:obol]
is_a: GO:0051962 ! positive regulation of nervous system development
is_a: GO:2000595 ! regulation of optic nerve formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0021634 ! optic nerve formation
relationship: positively_regulates GO:0021634 ! optic nerve formation
created_by: yaf
creation_date: 2011-04-11T03:41:39Z

[Term]
id: GO:2000598
name: regulation of cyclin catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cyclin catabolic process." [GOC:obol]
synonym: "regulation of cyclin breakdown" EXACT [GOC:obol]
synonym: "regulation of cyclin catabolism" EXACT [GOC:obol]
synonym: "regulation of cyclin degradation" EXACT [GOC:obol]
synonym: "regulation of degradation of cyclin" EXACT [GOC:obol]
is_a: GO:0000079 ! regulation of cyclin-dependent protein serine/threonine kinase activity
is_a: GO:0032434 ! regulation of proteasomal ubiquitin-dependent protein catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008054 ! negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation
relationship: regulates GO:0008054 ! negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation
created_by: dph
creation_date: 2011-04-12T08:15:48Z

[Term]
id: GO:2000599
name: negative regulation of cyclin catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cyclin catabolic process." [GOC:obol]
synonym: "negative regulation of cyclin breakdown" EXACT [GOC:obol]
synonym: "negative regulation of cyclin catabolism" EXACT [GOC:obol]
synonym: "negative regulation of cyclin degradation" EXACT [GOC:obol]
synonym: "negative regulation of degradation of cyclin" EXACT [GOC:obol]
is_a: GO:0032435 ! negative regulation of proteasomal ubiquitin-dependent protein catabolic process
is_a: GO:0045737 ! positive regulation of cyclin-dependent protein serine/threonine kinase activity
is_a: GO:2000598 ! regulation of cyclin catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008054 ! negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation
relationship: negatively_regulates GO:0008054 ! negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation
created_by: dph
creation_date: 2011-04-12T08:15:54Z

[Term]
id: GO:2000600
name: positive regulation of cyclin catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cyclin catabolic process." [GOC:obol]
synonym: "positive regulation of cyclin breakdown" EXACT [GOC:obol]
synonym: "positive regulation of cyclin catabolism" EXACT [GOC:obol]
synonym: "positive regulation of cyclin degradation" EXACT [GOC:obol]
synonym: "positive regulation of degradation of cyclin" EXACT [GOC:obol]
is_a: GO:0032436 ! positive regulation of proteasomal ubiquitin-dependent protein catabolic process
is_a: GO:2000598 ! regulation of cyclin catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008054 ! negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation
relationship: positively_regulates GO:0008054 ! negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation
created_by: dph
creation_date: 2011-04-12T08:16:00Z

[Term]
id: GO:2000601
name: positive regulation of Arp2/3 complex-mediated actin nucleation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of Arp2/3 complex-mediated actin nucleation." [PMID:21454476]
synonym: "positive regulation of actin filament branch nucleation" EXACT [GOC:obol]
synonym: "positive regulation of branched actin filament nucleation" EXACT [GOC:obol]
is_a: GO:0034315 ! regulation of Arp2/3 complex-mediated actin nucleation
is_a: GO:0051127 ! positive regulation of actin nucleation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034314 ! Arp2/3 complex-mediated actin nucleation
relationship: positively_regulates GO:0034314 ! Arp2/3 complex-mediated actin nucleation
created_by: rfoulger
creation_date: 2011-04-14T12:35:44Z

[Term]
id: GO:2000602
name: obsolete regulation of interphase of mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of interphase of mitotic cell cycle." [GOC:obol]
comment: This term was made obsolete as part of the cell cycle overhaul. This is because it was decided that cell cycle phases are intervals and so cannot be regulated, rather it is the transitions between the phases that are regulated.
synonym: "regulation of interphase of mitotic cell cycle" EXACT []
is_obsolete: true
created_by: pr
creation_date: 2011-04-15T03:52:25Z

[Term]
id: GO:2000603
name: regulation of secondary growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of secondary growth." [GOC:obol]
is_a: GO:0040008 ! regulation of growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0080117 ! secondary growth
relationship: regulates GO:0080117 ! secondary growth
created_by: tanyaberardini
creation_date: 2011-04-15T10:30:44Z

[Term]
id: GO:2000604
name: negative regulation of secondary growth
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of secondary growth." [GOC:obol]
is_a: GO:0045926 ! negative regulation of growth
is_a: GO:2000603 ! regulation of secondary growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0080117 ! secondary growth
relationship: negatively_regulates GO:0080117 ! secondary growth
created_by: tanyaberardini
creation_date: 2011-04-15T10:30:47Z

[Term]
id: GO:2000605
name: positive regulation of secondary growth
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of secondary growth." [GOC:obol]
is_a: GO:0045927 ! positive regulation of growth
is_a: GO:2000603 ! regulation of secondary growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0080117 ! secondary growth
relationship: positively_regulates GO:0080117 ! secondary growth
created_by: tanyaberardini
creation_date: 2011-04-15T10:30:49Z

[Term]
id: GO:2000606
name: regulation of cell proliferation involved in mesonephros development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell proliferation involved in mesonephros development." [GOC:obol]
is_a: GO:0061217 ! regulation of mesonephros development
is_a: GO:1901722 ! regulation of cell proliferation involved in kidney development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061209 ! cell proliferation involved in mesonephros development
relationship: regulates GO:0061209 ! cell proliferation involved in mesonephros development
created_by: yaf
creation_date: 2011-04-18T08:42:19Z

[Term]
id: GO:2000607
name: negative regulation of cell proliferation involved in mesonephros development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation involved in mesonephros development." [GOC:obol]
is_a: GO:0061218 ! negative regulation of mesonephros development
is_a: GO:1901723 ! negative regulation of cell proliferation involved in kidney development
is_a: GO:2000606 ! regulation of cell proliferation involved in mesonephros development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061209 ! cell proliferation involved in mesonephros development
relationship: negatively_regulates GO:0061209 ! cell proliferation involved in mesonephros development
created_by: yaf
creation_date: 2011-04-18T08:42:23Z

[Term]
id: GO:2000608
name: positive regulation of cell proliferation involved in mesonephros development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in mesonephros development." [GOC:obol]
is_a: GO:0061213 ! positive regulation of mesonephros development
is_a: GO:1901724 ! positive regulation of cell proliferation involved in kidney development
is_a: GO:2000606 ! regulation of cell proliferation involved in mesonephros development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061209 ! cell proliferation involved in mesonephros development
relationship: positively_regulates GO:0061209 ! cell proliferation involved in mesonephros development
created_by: yaf
creation_date: 2011-04-18T08:42:25Z

[Term]
id: GO:2000609
name: regulation of thyroid hormone generation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of thyroid hormone generation." [GOC:obol]
is_a: GO:0006521 ! regulation of cellular amino acid metabolic process
is_a: GO:0032350 ! regulation of hormone metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006590 ! thyroid hormone generation
relationship: regulates GO:0006590 ! thyroid hormone generation
created_by: yaf
creation_date: 2011-04-18T10:12:14Z

[Term]
id: GO:2000610
name: negative regulation of thyroid hormone generation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of thyroid hormone generation." [GOC:obol]
is_a: GO:0032351 ! negative regulation of hormone metabolic process
is_a: GO:0045763 ! negative regulation of cellular amino acid metabolic process
is_a: GO:2000609 ! regulation of thyroid hormone generation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006590 ! thyroid hormone generation
relationship: negatively_regulates GO:0006590 ! thyroid hormone generation
created_by: yaf
creation_date: 2011-04-18T10:12:19Z

[Term]
id: GO:2000611
name: positive regulation of thyroid hormone generation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of thyroid hormone generation." [GOC:obol]
is_a: GO:0032352 ! positive regulation of hormone metabolic process
is_a: GO:0045764 ! positive regulation of cellular amino acid metabolic process
is_a: GO:2000609 ! regulation of thyroid hormone generation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006590 ! thyroid hormone generation
relationship: positively_regulates GO:0006590 ! thyroid hormone generation
created_by: yaf
creation_date: 2011-04-18T10:12:22Z

[Term]
id: GO:2000612
name: regulation of thyroid-stimulating hormone secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of thyroid-stimulating hormone secretion." [GOC:obol]
synonym: "regulation of thyroid stimulating hormone secretion" EXACT [GOC:obol]
synonym: "regulation of TSH secretion" EXACT [GOC:obol]
is_a: GO:0090276 ! regulation of peptide hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070460 ! thyroid-stimulating hormone secretion
relationship: regulates GO:0070460 ! thyroid-stimulating hormone secretion
created_by: yaf
creation_date: 2011-04-18T12:56:16Z

[Term]
id: GO:2000613
name: negative regulation of thyroid-stimulating hormone secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of thyroid-stimulating hormone secretion." [GOC:obol]
synonym: "negative regulation of thyroid stimulating hormone secretion" EXACT [GOC:obol]
synonym: "negative regulation of TSH secretion" EXACT [GOC:obol]
is_a: GO:0090278 ! negative regulation of peptide hormone secretion
is_a: GO:2000612 ! regulation of thyroid-stimulating hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070460 ! thyroid-stimulating hormone secretion
relationship: negatively_regulates GO:0070460 ! thyroid-stimulating hormone secretion
created_by: yaf
creation_date: 2011-04-18T12:56:20Z

[Term]
id: GO:2000614
name: positive regulation of thyroid-stimulating hormone secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of thyroid-stimulating hormone secretion." [GOC:obol]
synonym: "positive regulation of thyroid stimulating hormone secretion" EXACT [GOC:obol]
synonym: "positive regulation of TSH secretion" EXACT [GOC:obol]
is_a: GO:0090277 ! positive regulation of peptide hormone secretion
is_a: GO:2000612 ! regulation of thyroid-stimulating hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070460 ! thyroid-stimulating hormone secretion
relationship: positively_regulates GO:0070460 ! thyroid-stimulating hormone secretion
created_by: yaf
creation_date: 2011-04-18T12:56:22Z

[Term]
id: GO:2000615
name: regulation of histone H3-K9 acetylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of histone H3-K9 acetylation." [GOC:BHF]
synonym: "regulation of histone H3 acetylation at K9" EXACT [GOC:obol]
synonym: "regulation of histone H3K9 acetylation" EXACT [GOC:obol]
is_a: GO:0035065 ! regulation of histone acetylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043970 ! histone H3-K9 acetylation
relationship: regulates GO:0043970 ! histone H3-K9 acetylation
created_by: vk
creation_date: 2011-04-18T03:15:59Z

[Term]
id: GO:2000616
name: negative regulation of histone H3-K9 acetylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K9 acetylation." [GOC:BHF]
synonym: "negative regulation of histone H3 acetylation at K9" EXACT [GOC:obol]
synonym: "negative regulation of histone H3K9 acetylation" EXACT [GOC:obol]
is_a: GO:0035067 ! negative regulation of histone acetylation
is_a: GO:2000615 ! regulation of histone H3-K9 acetylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043970 ! histone H3-K9 acetylation
relationship: negatively_regulates GO:0043970 ! histone H3-K9 acetylation
created_by: vk
creation_date: 2011-04-18T03:16:04Z

[Term]
id: GO:2000617
name: positive regulation of histone H3-K9 acetylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of histone H3-K9 acetylation." [GOC:BHF]
synonym: "positive regulation of histone H3 acetylation at K9" EXACT [GOC:obol]
synonym: "positive regulation of histone H3K9 acetylation" EXACT [GOC:obol]
is_a: GO:0035066 ! positive regulation of histone acetylation
is_a: GO:2000615 ! regulation of histone H3-K9 acetylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043970 ! histone H3-K9 acetylation
relationship: positively_regulates GO:0043970 ! histone H3-K9 acetylation
created_by: vk
creation_date: 2011-04-18T03:16:07Z

[Term]
id: GO:2000618
name: regulation of histone H4-K16 acetylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of histone H4-K16 acetylation." [GOC:BHF]
synonym: "regulation of histone H4 acetylation at K16" EXACT [GOC:obol]
is_a: GO:0090239 ! regulation of histone H4 acetylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043984 ! histone H4-K16 acetylation
relationship: regulates GO:0043984 ! histone H4-K16 acetylation
created_by: vk
creation_date: 2011-04-18T03:19:23Z

[Term]
id: GO:2000619
name: negative regulation of histone H4-K16 acetylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone H4-K16 acetylation." [GOC:BHF]
synonym: "negative regulation of histone H4 acetylation at K16" EXACT [GOC:obol]
is_a: GO:0090241 ! negative regulation of histone H4 acetylation
is_a: GO:2000618 ! regulation of histone H4-K16 acetylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043984 ! histone H4-K16 acetylation
relationship: negatively_regulates GO:0043984 ! histone H4-K16 acetylation
created_by: vk
creation_date: 2011-04-18T03:19:27Z

[Term]
id: GO:2000620
name: positive regulation of histone H4-K16 acetylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of histone H4-K16 acetylation." [GOC:BHF]
synonym: "positive regulation of histone H4 acetylation at K16" EXACT [GOC:obol]
is_a: GO:0090240 ! positive regulation of histone H4 acetylation
is_a: GO:2000618 ! regulation of histone H4-K16 acetylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043984 ! histone H4-K16 acetylation
relationship: positively_regulates GO:0043984 ! histone H4-K16 acetylation
created_by: vk
creation_date: 2011-04-18T03:19:30Z

[Term]
id: GO:2000621
name: regulation of DNA replication termination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA replication termination." [GOC:obol]
is_a: GO:0090329 ! regulation of DNA-dependent DNA replication
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006274 ! DNA replication termination
relationship: regulates GO:0006274 ! DNA replication termination
created_by: pr
creation_date: 2011-04-18T03:26:23Z

[Term]
id: GO:2000622
name: regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay." [GOC:obol]
synonym: "regulation of mRNA breakdown, nonsense-mediated decay" EXACT [GOC:obol]
synonym: "regulation of mRNA catabolic process, nonsense-mediated" EXACT [GOC:obol]
synonym: "regulation of mRNA catabolism, nonsense-mediated" EXACT [GOC:obol]
synonym: "regulation of mRNA degradation, nonsense-mediated decay" EXACT [GOC:obol]
synonym: "regulation of nonsense-mediated mRNA decay" EXACT [GOC:obol]
synonym: "regulation of nuclear mRNA catabolic process, nonsense-mediated decay" EXACT [GOC:obol]
is_a: GO:0061013 ! regulation of mRNA catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000184 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
relationship: regulates GO:0000184 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
created_by: pr
creation_date: 2011-04-18T03:32:42Z

[Term]
id: GO:2000623
name: negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay." [GOC:obol]
synonym: "negative regulation of mRNA breakdown, nonsense-mediated decay" EXACT [GOC:obol]
synonym: "negative regulation of mRNA catabolic process, nonsense-mediated" EXACT [GOC:obol]
synonym: "negative regulation of mRNA catabolism, nonsense-mediated" EXACT [GOC:obol]
synonym: "negative regulation of mRNA degradation, nonsense-mediated decay" EXACT [GOC:obol]
synonym: "negative regulation of nonsense-mediated mRNA decay" EXACT [GOC:obol]
synonym: "negative regulation of nuclear mRNA catabolic process, nonsense-mediated decay" EXACT [GOC:obol]
is_a: GO:1902373 ! negative regulation of mRNA catabolic process
is_a: GO:2000622 ! regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000184 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
relationship: negatively_regulates GO:0000184 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
created_by: pr
creation_date: 2011-04-18T03:32:46Z

[Term]
id: GO:2000624
name: positive regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay." [GOC:obol]
synonym: "positive regulation of mRNA breakdown, nonsense-mediated decay" EXACT [GOC:obol]
synonym: "positive regulation of mRNA catabolic process, nonsense-mediated" EXACT [GOC:obol]
synonym: "positive regulation of mRNA catabolism, nonsense-mediated" EXACT [GOC:obol]
synonym: "positive regulation of mRNA degradation, nonsense-mediated decay" EXACT [GOC:obol]
synonym: "positive regulation of nonsense-mediated mRNA decay" EXACT [GOC:obol]
synonym: "positive regulation of nuclear mRNA catabolic process, nonsense-mediated decay" EXACT [GOC:obol]
is_a: GO:0061014 ! positive regulation of mRNA catabolic process
is_a: GO:2000622 ! regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000184 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
relationship: positively_regulates GO:0000184 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
created_by: pr
creation_date: 2011-04-18T03:32:49Z

[Term]
id: GO:2000625
name: regulation of miRNA catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of miRNA catabolic process." [GOC:dph]
synonym: "regulation of microRNA catabolic process" EXACT [GOC:obol]
is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:2000628 ! regulation of miRNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010587 ! miRNA catabolic process
relationship: regulates GO:0010587 ! miRNA catabolic process
created_by: dph
creation_date: 2011-04-18T03:46:35Z

[Term]
id: GO:2000626
name: negative regulation of miRNA catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of miRNA catabolic process." [GOC:dph]
synonym: "negative regulation of microRNA catabolic process" EXACT [GOC:obol]
is_a: GO:1902369 ! negative regulation of RNA catabolic process
is_a: GO:2000625 ! regulation of miRNA catabolic process
is_a: GO:2000629 ! negative regulation of miRNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010587 ! miRNA catabolic process
relationship: negatively_regulates GO:0010587 ! miRNA catabolic process
created_by: dph
creation_date: 2011-04-18T03:46:39Z

[Term]
id: GO:2000627
name: positive regulation of miRNA catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of miRNA catabolic process." [GOC:dph]
synonym: "positive regulation of microRNA catabolic process" EXACT [GOC:obol]
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:2000625 ! regulation of miRNA catabolic process
is_a: GO:2000630 ! positive regulation of miRNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010587 ! miRNA catabolic process
relationship: positively_regulates GO:0010587 ! miRNA catabolic process
created_by: dph
creation_date: 2011-04-18T03:46:42Z

[Term]
id: GO:2000628
name: regulation of miRNA metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of miRNA metabolic process." [GOC:dph]
synonym: "regulation of microRNA metabolic process" EXACT [GOC:obol]
is_a: GO:0051252 ! regulation of RNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010586 ! miRNA metabolic process
relationship: regulates GO:0010586 ! miRNA metabolic process
created_by: dph
creation_date: 2011-04-18T03:47:54Z

[Term]
id: GO:2000629
name: negative regulation of miRNA metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of miRNA metabolic process." [GOC:dph]
synonym: "negative regulation of microRNA metabolic process" EXACT [GOC:obol]
is_a: GO:0051253 ! negative regulation of RNA metabolic process
is_a: GO:2000628 ! regulation of miRNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010586 ! miRNA metabolic process
relationship: negatively_regulates GO:0010586 ! miRNA metabolic process
created_by: dph
creation_date: 2011-04-18T03:47:58Z

[Term]
id: GO:2000630
name: positive regulation of miRNA metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of miRNA metabolic process." [GOC:dph]
synonym: "positive regulation of microRNA metabolic process" EXACT [GOC:obol]
is_a: GO:0051254 ! positive regulation of RNA metabolic process
is_a: GO:2000628 ! regulation of miRNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010586 ! miRNA metabolic process
relationship: positively_regulates GO:0010586 ! miRNA metabolic process
created_by: dph
creation_date: 2011-04-18T03:48:01Z

[Term]
id: GO:2000631
name: regulation of pre-miRNA processing
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pre-microRNA processing." [GOC:dph, GOC:sl]
synonym: "regulation of pre-microRNA processing" EXACT []
is_a: GO:1903798 ! regulation of production of miRNAs involved in gene silencing by miRNA
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031054 ! pre-miRNA processing
relationship: regulates GO:0031054 ! pre-miRNA processing
created_by: dph
creation_date: 2011-04-18T03:50:16Z

[Term]
id: GO:2000632
name: negative regulation of pre-miRNA processing
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of pre-microRNA processing." [GOC:dph, GOC:sl]
synonym: "negative regulation of pre-microRNA processing" EXACT [GOC:obol]
is_a: GO:1903799 ! negative regulation of production of miRNAs involved in gene silencing by miRNA
is_a: GO:2000631 ! regulation of pre-miRNA processing
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0031054 ! pre-miRNA processing
relationship: negatively_regulates GO:0031054 ! pre-miRNA processing
created_by: dph
creation_date: 2011-04-18T03:50:19Z

[Term]
id: GO:2000633
name: positive regulation of pre-miRNA processing
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pre-microRNA processing." [GOC:dph, GOC:sl]
synonym: "positive regulation of pre-microRNA processing" EXACT [GOC:obol]
is_a: GO:1903800 ! positive regulation of production of miRNAs involved in gene silencing by miRNA
is_a: GO:2000631 ! regulation of pre-miRNA processing
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0031054 ! pre-miRNA processing
relationship: positively_regulates GO:0031054 ! pre-miRNA processing
created_by: dph
creation_date: 2011-04-18T03:50:22Z

[Term]
id: GO:2000634
name: regulation of primary miRNA processing
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of primary microRNA processing." [GOC:dph, GOC:sl]
synonym: "regulation of pri-miRNA processing" EXACT [GOC:obol]
synonym: "regulation of primary microRNA processing" EXACT [GOC:obol]
is_a: GO:1903798 ! regulation of production of miRNAs involved in gene silencing by miRNA
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031053 ! primary miRNA processing
relationship: regulates GO:0031053 ! primary miRNA processing
created_by: dph
creation_date: 2011-04-18T03:50:50Z

[Term]
id: GO:2000635
name: negative regulation of primary miRNA processing
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of primary microRNA processing." [GOC:dph, GOC:sl]
synonym: "negative regulation of pri-miRNA processing" EXACT [GOC:obol]
synonym: "negative regulation of primary microRNA processing" EXACT [GOC:obol]
is_a: GO:1903799 ! negative regulation of production of miRNAs involved in gene silencing by miRNA
is_a: GO:2000634 ! regulation of primary miRNA processing
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0031053 ! primary miRNA processing
relationship: negatively_regulates GO:0031053 ! primary miRNA processing
created_by: dph
creation_date: 2011-04-18T03:50:53Z

[Term]
id: GO:2000636
name: positive regulation of primary miRNA processing
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of primary microRNA processing." [GOC:dph, GOC:sl]
synonym: "positive regulation of pri-miRNA processing" EXACT [GOC:obol]
synonym: "positive regulation of primary microRNA processing" EXACT [GOC:obol]
is_a: GO:1903800 ! positive regulation of production of miRNAs involved in gene silencing by miRNA
is_a: GO:2000634 ! regulation of primary miRNA processing
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0031053 ! primary miRNA processing
relationship: positively_regulates GO:0031053 ! primary miRNA processing
created_by: dph
creation_date: 2011-04-18T03:50:56Z

[Term]
id: GO:2000637
name: positive regulation of gene silencing by miRNA
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of gene silencing by miRNA." [GOC:dph]
synonym: "positive regulation of gene silencing by microRNA" RELATED [GOC:pr]
synonym: "positive regulation of microRNA-mediated gene silencing" EXACT [GOC:obol]
synonym: "positive regulation of miRNA-mediated gene silencing" EXACT [GOC:obol]
is_a: GO:0060148 ! positive regulation of posttranscriptional gene silencing
is_a: GO:0060964 ! regulation of gene silencing by miRNA
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035195 ! gene silencing by miRNA
relationship: positively_regulates GO:0035195 ! gene silencing by miRNA
created_by: dph
creation_date: 2011-04-18T03:51:24Z

[Term]
id: GO:2000638
name: regulation of SREBP signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the SREBP signaling pathway." [GOC:BHF]
synonym: "regulation of SREBP-mediated signaling pathway" EXACT [GOC:bf, GOC:vw]
synonym: "regulation of SREBP-mediated signalling pathway" EXACT [GOC:obol]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0080135 ! regulation of cellular response to stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032933 ! SREBP signaling pathway
relationship: regulates GO:0032933 ! SREBP signaling pathway
created_by: vk
creation_date: 2011-04-20T02:45:59Z

[Term]
id: GO:2000639
name: negative regulation of SREBP signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the SREBP signaling pathway." [GOC:BHF]
synonym: "negative regulation of SREBP-mediated signaling pathway" EXACT [GOC:bf, GOC:vw]
synonym: "negative regulation of SREBP-mediated signalling pathway" EXACT [GOC:obol]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:2000638 ! regulation of SREBP signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032933 ! SREBP signaling pathway
relationship: negatively_regulates GO:0032933 ! SREBP signaling pathway
created_by: vk
creation_date: 2011-04-20T02:46:02Z

[Term]
id: GO:2000640
name: positive regulation of SREBP signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the SREBP signaling pathway." [GOC:BHF]
synonym: "positive regulation of SREBP-mediated signaling pathway" EXACT [GOC:bf, GOC:vw]
synonym: "positive regulation of SREBP-mediated signalling pathway" EXACT [GOC:obol]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:2000638 ! regulation of SREBP signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032933 ! SREBP signaling pathway
relationship: positively_regulates GO:0032933 ! SREBP signaling pathway
created_by: vk
creation_date: 2011-04-20T02:46:05Z

[Term]
id: GO:2000641
name: regulation of early endosome to late endosome transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of early endosome to late endosome transport." [GOC:BHF]
is_a: GO:0060627 ! regulation of vesicle-mediated transport
is_a: GO:1903335 ! regulation of vacuolar transport
is_a: GO:1903649 ! regulation of cytoplasmic transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045022 ! early endosome to late endosome transport
relationship: regulates GO:0045022 ! early endosome to late endosome transport
created_by: vk
creation_date: 2011-04-21T11:20:02Z

[Term]
id: GO:2000642
name: negative regulation of early endosome to late endosome transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of early endosome to late endosome transport." [GOC:BHF]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:1903336 ! negative regulation of vacuolar transport
is_a: GO:1903650 ! negative regulation of cytoplasmic transport
is_a: GO:2000641 ! regulation of early endosome to late endosome transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045022 ! early endosome to late endosome transport
relationship: negatively_regulates GO:0045022 ! early endosome to late endosome transport
created_by: vk
creation_date: 2011-04-21T11:20:06Z

[Term]
id: GO:2000643
name: positive regulation of early endosome to late endosome transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of early endosome to late endosome transport." [GOC:BHF]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:1903337 ! positive regulation of vacuolar transport
is_a: GO:1903651 ! positive regulation of cytoplasmic transport
is_a: GO:2000641 ! regulation of early endosome to late endosome transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045022 ! early endosome to late endosome transport
relationship: positively_regulates GO:0045022 ! early endosome to late endosome transport
created_by: vk
creation_date: 2011-04-21T11:20:09Z

[Term]
id: GO:2000644
name: regulation of receptor catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of receptor catabolic process." [GOC:BHF]
synonym: "regulation of receptor breakdown" EXACT [GOC:obol]
synonym: "regulation of receptor catabolism" EXACT [GOC:obol]
synonym: "regulation of receptor degradation" EXACT [GOC:obol]
is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:0060255 ! regulation of macromolecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032801 ! receptor catabolic process
relationship: regulates GO:0032801 ! receptor catabolic process
created_by: vk
creation_date: 2011-04-21T11:20:18Z

[Term]
id: GO:2000645
name: negative regulation of receptor catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of receptor catabolic process." [GOC:BHF]
synonym: "negative regulation of receptor breakdown" EXACT [GOC:obol]
synonym: "negative regulation of receptor catabolism" EXACT [GOC:obol]
synonym: "negative regulation of receptor degradation" EXACT [GOC:obol]
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:2000644 ! regulation of receptor catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032801 ! receptor catabolic process
relationship: negatively_regulates GO:0032801 ! receptor catabolic process
created_by: vk
creation_date: 2011-04-21T11:20:22Z

[Term]
id: GO:2000646
name: positive regulation of receptor catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of receptor catabolic process." [GOC:BHF]
synonym: "positive regulation of receptor breakdown" EXACT [GOC:obol]
synonym: "positive regulation of receptor catabolism" EXACT [GOC:obol]
synonym: "positive regulation of receptor degradation" EXACT [GOC:obol]
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:2000644 ! regulation of receptor catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032801 ! receptor catabolic process
relationship: positively_regulates GO:0032801 ! receptor catabolic process
created_by: vk
creation_date: 2011-04-21T11:20:25Z

[Term]
id: GO:2000647
name: negative regulation of stem cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of stem cell proliferation." [GOC:dph]
is_a: GO:0008285 ! negative regulation of cell proliferation
is_a: GO:0072091 ! regulation of stem cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072089 ! stem cell proliferation
relationship: negatively_regulates GO:0072089 ! stem cell proliferation
created_by: dph
creation_date: 2011-04-27T01:04:22Z

[Term]
id: GO:2000648
name: positive regulation of stem cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of stem cell proliferation." [GOC:dph]
is_a: GO:0008284 ! positive regulation of cell proliferation
is_a: GO:0072091 ! regulation of stem cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072089 ! stem cell proliferation
relationship: positively_regulates GO:0072089 ! stem cell proliferation
created_by: dph
creation_date: 2011-04-27T01:04:25Z

[Term]
id: GO:2000649
name: regulation of sodium ion transmembrane transporter activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sodium ion transmembrane transporter activity." [GOC:obol]
synonym: "regulation of sodium transporter activity" EXACT [GOC:obol]
is_a: GO:0032412 ! regulation of ion transmembrane transporter activity
is_a: GO:1902305 ! regulation of sodium ion transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0015081 ! sodium ion transmembrane transporter activity
relationship: regulates GO:0015081 ! sodium ion transmembrane transporter activity
created_by: yaf
creation_date: 2011-04-28T08:42:53Z

[Term]
id: GO:2000650
name: negative regulation of sodium ion transmembrane transporter activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembrane transporter activity." [GOC:obol]
synonym: "negative regulation of sodium transporter activity" EXACT [GOC:obol]
is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity
is_a: GO:1902306 ! negative regulation of sodium ion transmembrane transport
is_a: GO:2000649 ! regulation of sodium ion transmembrane transporter activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0015081 ! sodium ion transmembrane transporter activity
relationship: negatively_regulates GO:0015081 ! sodium ion transmembrane transporter activity
created_by: yaf
creation_date: 2011-04-28T08:42:57Z

[Term]
id: GO:2000651
name: positive regulation of sodium ion transmembrane transporter activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transporter activity." [GOC:obol]
synonym: "positive regulation of sodium transporter activity" EXACT [GOC:obol]
is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity
is_a: GO:1902307 ! positive regulation of sodium ion transmembrane transport
is_a: GO:2000649 ! regulation of sodium ion transmembrane transporter activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0015081 ! sodium ion transmembrane transporter activity
relationship: positively_regulates GO:0015081 ! sodium ion transmembrane transporter activity
created_by: yaf
creation_date: 2011-04-28T08:43:00Z

[Term]
id: GO:2000652
name: regulation of secondary cell wall biogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of secondary cell wall biogenesis." [GOC:obol]
synonym: "regulation of cellulose and pectin-containing secondary cell wall biogenesis" EXACT [GOC:obol]
synonym: "regulation of plant-type secondary cell wall biogenesis" EXACT [GOC:obol]
synonym: "regulation of secondary cell wall anabolism" RELATED [GOC:obol]
synonym: "regulation of secondary cell wall biosynthetic process" RELATED [GOC:obol]
synonym: "regulation of secondary cell wall formation" RELATED [GOC:obol]
synonym: "regulation of secondary cell wall synthesis" RELATED [GOC:obol]
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:1903338 ! regulation of cell wall organization or biogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009834 ! plant-type secondary cell wall biogenesis
relationship: regulates GO:0009834 ! plant-type secondary cell wall biogenesis
created_by: dhl
creation_date: 2011-04-29T08:50:02Z

[Term]
id: GO:2000653
name: regulation of genetic imprinting
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of genetic imprinting." [GOC:BHF]
synonym: "regulation of DNA imprinting" EXACT [GOC:obol]
is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process
is_a: GO:0060255 ! regulation of macromolecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071514 ! genetic imprinting
relationship: regulates GO:0071514 ! genetic imprinting
created_by: vk
creation_date: 2011-04-30T02:42:19Z

[Term]
id: GO:2000654
name: regulation of cellular response to testosterone stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular response to testosterone stimulus." [GOC:BHF]
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:1901419 ! regulation of response to alcohol
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071394 ! cellular response to testosterone stimulus
relationship: regulates GO:0071394 ! cellular response to testosterone stimulus
created_by: vk
creation_date: 2011-05-02T03:23:56Z

[Term]
id: GO:2000655
name: negative regulation of cellular response to testosterone stimulus
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to testosterone stimulus." [GOC:BHF]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:1901420 ! negative regulation of response to alcohol
is_a: GO:2000654 ! regulation of cellular response to testosterone stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071394 ! cellular response to testosterone stimulus
relationship: negatively_regulates GO:0071394 ! cellular response to testosterone stimulus
created_by: vk
creation_date: 2011-05-02T03:23:59Z

[Term]
id: GO:2000656
name: regulation of apolipoprotein binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of apolipoprotein binding." [GOC:BHF]
is_a: GO:0043393 ! regulation of protein binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034185 ! apolipoprotein binding
relationship: regulates GO:0034185 ! apolipoprotein binding
created_by: vk
creation_date: 2011-05-02T05:33:41Z

[Term]
id: GO:2000657
name: negative regulation of apolipoprotein binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of apolipoprotein binding." [GOC:BHF]
is_a: GO:0032091 ! negative regulation of protein binding
is_a: GO:2000656 ! regulation of apolipoprotein binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034185 ! apolipoprotein binding
relationship: negatively_regulates GO:0034185 ! apolipoprotein binding
created_by: vk
creation_date: 2011-05-02T05:33:44Z

[Term]
id: GO:2000658
name: positive regulation of apolipoprotein binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of apolipoprotein binding." [GOC:BHF]
is_a: GO:0032092 ! positive regulation of protein binding
is_a: GO:2000656 ! regulation of apolipoprotein binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034185 ! apolipoprotein binding
relationship: positively_regulates GO:0034185 ! apolipoprotein binding
created_by: vk
creation_date: 2011-05-02T05:33:46Z

[Term]
id: GO:2000659
name: regulation of interleukin-1-mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of interleukin-1-mediated signaling pathway." [GOC:obol]
synonym: "regulation of IL-1 alpha-mediated signaling pathway" RELATED [GOC:obol]
synonym: "regulation of IL-1 beta-mediated signaling pathway" RELATED [GOC:obol]
synonym: "regulation of IL-1-mediated signaling pathway" EXACT [GOC:obol]
synonym: "regulation of interleukin-1 alpha-mediated signaling pathway" RELATED [GOC:obol]
synonym: "regulation of interleukin-1 beta-mediated signaling pathway" RELATED [GOC:obol]
synonym: "regulation of interleukin-1-mediated signalling pathway" EXACT [GOC:obol]
is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070498 ! interleukin-1-mediated signaling pathway
relationship: regulates GO:0070498 ! interleukin-1-mediated signaling pathway
created_by: dph
creation_date: 2011-05-03T07:13:31Z

[Term]
id: GO:2000660
name: negative regulation of interleukin-1-mediated signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-1-mediated signaling pathway." [GOC:obol]
synonym: "negative regulation of IL-1 alpha-mediated signaling pathway" RELATED [GOC:obol]
synonym: "negative regulation of IL-1 beta-mediated signaling pathway" RELATED [GOC:obol]
synonym: "negative regulation of IL-1-mediated signaling pathway" EXACT [GOC:obol]
synonym: "negative regulation of interleukin-1 alpha-mediated signaling pathway" RELATED [GOC:obol]
synonym: "negative regulation of interleukin-1 beta-mediated signaling pathway" RELATED [GOC:obol]
synonym: "negative regulation of interleukin-1-mediated signalling pathway" EXACT [GOC:obol]
is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway
is_a: GO:2000659 ! regulation of interleukin-1-mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070498 ! interleukin-1-mediated signaling pathway
relationship: negatively_regulates GO:0070498 ! interleukin-1-mediated signaling pathway
created_by: dph
creation_date: 2011-05-03T07:13:37Z

[Term]
id: GO:2000661
name: positive regulation of interleukin-1-mediated signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of interleukin-1-mediated signaling pathway." [GOC:obol]
synonym: "positive regulation of IL-1 alpha-mediated signaling pathway" RELATED [GOC:obol]
synonym: "positive regulation of IL-1 beta-mediated signaling pathway" RELATED [GOC:obol]
synonym: "positive regulation of IL-1-mediated signaling pathway" EXACT [GOC:obol]
synonym: "positive regulation of interleukin-1 alpha-mediated signaling pathway" RELATED [GOC:obol]
synonym: "positive regulation of interleukin-1 beta-mediated signaling pathway" RELATED [GOC:obol]
synonym: "positive regulation of interleukin-1-mediated signalling pathway" EXACT [GOC:obol]
is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway
is_a: GO:2000659 ! regulation of interleukin-1-mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070498 ! interleukin-1-mediated signaling pathway
relationship: positively_regulates GO:0070498 ! interleukin-1-mediated signaling pathway
created_by: dph
creation_date: 2011-05-03T07:13:40Z

[Term]
id: GO:2000662
name: regulation of interleukin-5 secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of interleukin-5 secretion." [GOC:obol]
synonym: "regulation of IL-5 secretion" EXACT [GOC:obol]
is_a: GO:0032674 ! regulation of interleukin-5 production
is_a: GO:0050707 ! regulation of cytokine secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072603 ! interleukin-5 secretion
relationship: regulates GO:0072603 ! interleukin-5 secretion
created_by: yaf
creation_date: 2011-05-06T02:59:02Z

[Term]
id: GO:2000663
name: negative regulation of interleukin-5 secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-5 secretion." [GOC:obol]
synonym: "negative regulation of IL-5 secretion" EXACT [GOC:obol]
is_a: GO:0032714 ! negative regulation of interleukin-5 production
is_a: GO:0050710 ! negative regulation of cytokine secretion
is_a: GO:2000662 ! regulation of interleukin-5 secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072603 ! interleukin-5 secretion
relationship: negatively_regulates GO:0072603 ! interleukin-5 secretion
created_by: yaf
creation_date: 2011-05-06T02:59:05Z

[Term]
id: GO:2000664
name: positive regulation of interleukin-5 secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of interleukin-5 secretion." [GOC:obol]
synonym: "positive regulation of IL-5 secretion" EXACT [GOC:obol]
is_a: GO:0032754 ! positive regulation of interleukin-5 production
is_a: GO:0050715 ! positive regulation of cytokine secretion
is_a: GO:2000662 ! regulation of interleukin-5 secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072603 ! interleukin-5 secretion
relationship: positively_regulates GO:0072603 ! interleukin-5 secretion
created_by: yaf
creation_date: 2011-05-06T02:59:07Z

[Term]
id: GO:2000665
name: regulation of interleukin-13 secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of interleukin-13 secretion." [GOC:obol]
synonym: "regulation of IL-13 secretion" EXACT [GOC:obol]
is_a: GO:0032656 ! regulation of interleukin-13 production
is_a: GO:0050707 ! regulation of cytokine secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072611 ! interleukin-13 secretion
relationship: regulates GO:0072611 ! interleukin-13 secretion
created_by: yaf
creation_date: 2011-05-06T03:24:19Z

[Term]
id: GO:2000666
name: negative regulation of interleukin-13 secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-13 secretion." [GOC:obol]
synonym: "negative regulation of IL-13 secretion" EXACT [GOC:obol]
is_a: GO:0032696 ! negative regulation of interleukin-13 production
is_a: GO:0050710 ! negative regulation of cytokine secretion
is_a: GO:2000665 ! regulation of interleukin-13 secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072611 ! interleukin-13 secretion
relationship: negatively_regulates GO:0072611 ! interleukin-13 secretion
created_by: yaf
creation_date: 2011-05-06T03:24:22Z

[Term]
id: GO:2000667
name: positive regulation of interleukin-13 secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of interleukin-13 secretion." [GOC:obol]
synonym: "positive regulation of IL-13 secretion" EXACT [GOC:obol]
is_a: GO:0032736 ! positive regulation of interleukin-13 production
is_a: GO:0050715 ! positive regulation of cytokine secretion
is_a: GO:2000665 ! regulation of interleukin-13 secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072611 ! interleukin-13 secretion
relationship: positively_regulates GO:0072611 ! interleukin-13 secretion
created_by: yaf
creation_date: 2011-05-06T03:24:25Z

[Term]
id: GO:2000668
name: regulation of dendritic cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dendritic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol]
synonym: "regulation of dendritic cell apoptosis" NARROW []
is_a: GO:2000106 ! regulation of leukocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097048 ! dendritic cell apoptotic process
relationship: regulates GO:0097048 ! dendritic cell apoptotic process
created_by: pr
creation_date: 2011-05-09T07:34:16Z

[Term]
id: GO:2000669
name: negative regulation of dendritic cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol]
synonym: "negative regulation of dendritic cell apoptosis" NARROW []
is_a: GO:2000107 ! negative regulation of leukocyte apoptotic process
is_a: GO:2000668 ! regulation of dendritic cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097048 ! dendritic cell apoptotic process
relationship: negatively_regulates GO:0097048 ! dendritic cell apoptotic process
created_by: pr
creation_date: 2011-05-09T07:34:21Z

[Term]
id: GO:2000670
name: positive regulation of dendritic cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of dendritic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol]
synonym: "positive regulation of dendritic cell apoptosis" NARROW []
is_a: GO:2000108 ! positive regulation of leukocyte apoptotic process
is_a: GO:2000668 ! regulation of dendritic cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097048 ! dendritic cell apoptotic process
relationship: positively_regulates GO:0097048 ! dendritic cell apoptotic process
created_by: pr
creation_date: 2011-05-09T07:34:26Z

[Term]
id: GO:2000671
name: regulation of motor neuron apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of motor neuron apoptotic process." [GOC:mtg_apoptosis, GOC:obol]
synonym: "regulation of motoneuron apoptosis" EXACT [GOC:obol]
synonym: "regulation of motor neuron apoptosis" NARROW []
is_a: GO:0043523 ! regulation of neuron apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097049 ! motor neuron apoptotic process
relationship: regulates GO:0097049 ! motor neuron apoptotic process
created_by: pr
creation_date: 2011-05-09T10:56:17Z

[Term]
id: GO:2000672
name: negative regulation of motor neuron apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron apoptotic process." [GOC:mtg_apoptosis, GOC:obol]
synonym: "negative regulation of motoneuron apoptosis" EXACT [GOC:obol]
synonym: "negative regulation of motor neuron apoptosis" NARROW []
is_a: GO:0043524 ! negative regulation of neuron apoptotic process
is_a: GO:2000671 ! regulation of motor neuron apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097049 ! motor neuron apoptotic process
relationship: negatively_regulates GO:0097049 ! motor neuron apoptotic process
created_by: pr
creation_date: 2011-05-09T10:56:21Z

[Term]
id: GO:2000673
name: positive regulation of motor neuron apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of motor neuron apoptotic process." [GOC:mtg_apoptosis, GOC:obol]
synonym: "positive regulation of motoneuron apoptosis" EXACT [GOC:obol]
synonym: "positive regulation of motor neuron apoptosis" NARROW []
is_a: GO:0043525 ! positive regulation of neuron apoptotic process
is_a: GO:2000671 ! regulation of motor neuron apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097049 ! motor neuron apoptotic process
relationship: positively_regulates GO:0097049 ! motor neuron apoptotic process
created_by: pr
creation_date: 2011-05-09T10:56:24Z

[Term]
id: GO:2000674
name: regulation of type B pancreatic cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of type B pancreatic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol]
synonym: "regulation of pancreatic B cell apoptosis" EXACT [GOC:obol]
synonym: "regulation of pancreatic beta cell apoptosis" EXACT [GOC:obol]
synonym: "regulation of type B pancreatic cell apoptosis" NARROW []
is_a: GO:1904035 ! regulation of epithelial cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097050 ! type B pancreatic cell apoptotic process
relationship: regulates GO:0097050 ! type B pancreatic cell apoptotic process
created_by: pr
creation_date: 2011-05-09T11:51:09Z

[Term]
id: GO:2000675
name: negative regulation of type B pancreatic cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol]
synonym: "negative regulation of pancreatic B cell apoptosis" EXACT [GOC:obol]
synonym: "negative regulation of pancreatic beta cell apoptosis" EXACT [GOC:obol]
synonym: "negative regulation of type B pancreatic cell apoptosis" NARROW []
is_a: GO:1904036 ! negative regulation of epithelial cell apoptotic process
is_a: GO:2000674 ! regulation of type B pancreatic cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097050 ! type B pancreatic cell apoptotic process
relationship: negatively_regulates GO:0097050 ! type B pancreatic cell apoptotic process
created_by: pr
creation_date: 2011-05-09T11:51:12Z

[Term]
id: GO:2000676
name: positive regulation of type B pancreatic cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of type B pancreatic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol]
synonym: "positive regulation of pancreatic B cell apoptosis" EXACT [GOC:obol]
synonym: "positive regulation of pancreatic beta cell apoptosis" EXACT [GOC:obol]
synonym: "positive regulation of type B pancreatic cell apoptosis" NARROW []
is_a: GO:1904037 ! positive regulation of epithelial cell apoptotic process
is_a: GO:2000674 ! regulation of type B pancreatic cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097050 ! type B pancreatic cell apoptotic process
relationship: positively_regulates GO:0097050 ! type B pancreatic cell apoptotic process
created_by: pr
creation_date: 2011-05-09T11:51:15Z

[Term]
id: GO:2000677
name: regulation of transcription regulatory region DNA binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription regulatory region DNA binding." [GOC:obol]
is_a: GO:0051101 ! regulation of DNA binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044212 ! transcription regulatory region DNA binding
relationship: regulates GO:0044212 ! transcription regulatory region DNA binding
created_by: yaf
creation_date: 2011-05-09T03:28:11Z

[Term]
id: GO:2000678
name: negative regulation of transcription regulatory region DNA binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription regulatory region DNA binding." [GOC:obol]
is_a: GO:0043392 ! negative regulation of DNA binding
is_a: GO:2000677 ! regulation of transcription regulatory region DNA binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044212 ! transcription regulatory region DNA binding
relationship: negatively_regulates GO:0044212 ! transcription regulatory region DNA binding
created_by: yaf
creation_date: 2011-05-09T03:28:14Z

[Term]
id: GO:2000679
name: positive regulation of transcription regulatory region DNA binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transcription regulatory region DNA binding." [GOC:obol]
is_a: GO:0043388 ! positive regulation of DNA binding
is_a: GO:2000677 ! regulation of transcription regulatory region DNA binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044212 ! transcription regulatory region DNA binding
relationship: positively_regulates GO:0044212 ! transcription regulatory region DNA binding
created_by: yaf
creation_date: 2011-05-09T03:28:17Z

[Term]
id: GO:2000680
name: regulation of rubidium ion transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of rubidium ion transport." [GOC:yaf]
synonym: "regulation of Rb+ transport" EXACT [GOC:obol]
synonym: "regulation of rubidium cation transport" EXACT [GOC:obol]
is_a: GO:0010959 ! regulation of metal ion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035826 ! rubidium ion transport
relationship: regulates GO:0035826 ! rubidium ion transport
created_by: rfoulger
creation_date: 2011-05-10T10:54:31Z

[Term]
id: GO:2000681
name: negative regulation of rubidium ion transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of rubidium ion transport." [GOC:yaf]
synonym: "negative regulation of Rb+ transport" EXACT [GOC:obol]
synonym: "negative regulation of rubidium cation transport" EXACT [GOC:obol]
is_a: GO:0043271 ! negative regulation of ion transport
is_a: GO:2000680 ! regulation of rubidium ion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035826 ! rubidium ion transport
relationship: negatively_regulates GO:0035826 ! rubidium ion transport
created_by: rfoulger
creation_date: 2011-05-10T10:54:34Z

[Term]
id: GO:2000682
name: positive regulation of rubidium ion transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of rubidium ion transport." [GOC:yaf]
synonym: "positive regulation of Rb+ transport" EXACT [GOC:obol]
synonym: "positive regulation of rubidium cation transport" EXACT [GOC:obol]
is_a: GO:0043270 ! positive regulation of ion transport
is_a: GO:2000680 ! regulation of rubidium ion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035826 ! rubidium ion transport
relationship: positively_regulates GO:0035826 ! rubidium ion transport
created_by: rfoulger
creation_date: 2011-05-10T10:54:37Z

[Term]
id: GO:2000683
name: regulation of cellular response to X-ray
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular response to X-ray." [GOC:obol]
synonym: "regulation of cellular response to X-ray radiation stimulus" EXACT [GOC:obol]
is_a: GO:0048583 ! regulation of response to stimulus
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071481 ! cellular response to X-ray
relationship: regulates GO:0071481 ! cellular response to X-ray
created_by: yaf
creation_date: 2011-05-10T01:40:41Z

[Term]
id: GO:2000684
name: negative regulation of cellular response to X-ray
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to X-ray." [GOC:obol]
synonym: "negative regulation of cellular response to X-ray radiation stimulus" EXACT [GOC:obol]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:2000683 ! regulation of cellular response to X-ray
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071481 ! cellular response to X-ray
relationship: negatively_regulates GO:0071481 ! cellular response to X-ray
created_by: yaf
creation_date: 2011-05-10T01:40:45Z

[Term]
id: GO:2000685
name: positive regulation of cellular response to X-ray
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellular response to X-ray." [GOC:obol]
synonym: "positive regulation of cellular response to X-ray radiation stimulus" EXACT [GOC:obol]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:2000683 ! regulation of cellular response to X-ray
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071481 ! cellular response to X-ray
relationship: positively_regulates GO:0071481 ! cellular response to X-ray
created_by: yaf
creation_date: 2011-05-10T01:40:49Z

[Term]
id: GO:2000686
name: regulation of rubidium ion transmembrane transporter activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of rubidium ion transmembrane transporter activity." [GOC:yaf]
synonym: "regulation of Rb+ transmembrane transporter activity" EXACT [GOC:obol]
synonym: "regulation of rubidium cation transmembrane transporter activity" EXACT [GOC:obol]
synonym: "regulation of rubidium transmembrane transporter activity" RELATED [GOC:obol]
is_a: GO:0032412 ! regulation of ion transmembrane transporter activity
is_a: GO:1904062 ! regulation of cation transmembrane transport
is_a: GO:2000680 ! regulation of rubidium ion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035827 ! rubidium ion transmembrane transporter activity
relationship: regulates GO:0035827 ! rubidium ion transmembrane transporter activity
created_by: rfoulger
creation_date: 2011-05-11T09:27:29Z

[Term]
id: GO:2000687
name: negative regulation of rubidium ion transmembrane transporter activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of rubidium ion transmembrane transporter activity." [GOC:yaf]
synonym: "negative regulation of Rb+ transmembrane transporter activity" EXACT [GOC:obol]
synonym: "negative regulation of rubidium cation transmembrane transporter activity" EXACT [GOC:obol]
synonym: "negative regulation of rubidium transmembrane transporter activity" RELATED [GOC:obol]
is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity
is_a: GO:1904063 ! negative regulation of cation transmembrane transport
is_a: GO:2000681 ! negative regulation of rubidium ion transport
is_a: GO:2000686 ! regulation of rubidium ion transmembrane transporter activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035827 ! rubidium ion transmembrane transporter activity
relationship: negatively_regulates GO:0035827 ! rubidium ion transmembrane transporter activity
created_by: rfoulger
creation_date: 2011-05-11T09:27:32Z

[Term]
id: GO:2000688
name: positive regulation of rubidium ion transmembrane transporter activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of rubidium ion transmembrane transporter activity." [GOC:yaf]
synonym: "positive regulation of Rb+ transmembrane transporter activity" EXACT [GOC:obol]
synonym: "positive regulation of rubidium cation transmembrane transporter activity" EXACT [GOC:obol]
synonym: "positive regulation of rubidium transmembrane transporter activity" RELATED [GOC:obol]
is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity
is_a: GO:1904064 ! positive regulation of cation transmembrane transport
is_a: GO:2000682 ! positive regulation of rubidium ion transport
is_a: GO:2000686 ! regulation of rubidium ion transmembrane transporter activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035827 ! rubidium ion transmembrane transporter activity
relationship: positively_regulates GO:0035827 ! rubidium ion transmembrane transporter activity
created_by: rfoulger
creation_date: 2011-05-11T09:27:33Z

[Term]
id: GO:2000689
name: actomyosin contractile ring assembly actin filament organization
namespace: biological_process
def: "An actin filament organization process that contributes to actomyosin contractile ring assembly during cytokinesis." [GOC:mah]
synonym: "actin filament organisation of constriction ring assembly" RELATED [GOC:obol]
synonym: "actin filament organisation of contractile ring assembly" EXACT [GOC:obol]
synonym: "actin filament organisation of cytokinesis, actomyosin contractile ring assembly" EXACT [GOC:obol]
synonym: "actin filament organisation of cytokinesis, actomyosin contractile ring formation" RELATED [GOC:obol]
synonym: "actin filament organisation of cytokinesis, actomyosin ring biosynthesis" RELATED [GOC:obol]
synonym: "actin filament organisation of cytokinesis, actomyosin ring formation" RELATED [GOC:obol]
synonym: "actin filament organisation of cytokinesis, contractile ring assembly" RELATED [GOC:obol]
synonym: "actin filament organization involved in cytokinetic actomyosin contractile ring assembly" EXACT []
synonym: "actin filament organization of constriction ring assembly" RELATED [GOC:obol]
synonym: "actin filament organization of contractile ring assembly" EXACT [GOC:obol]
synonym: "actin filament organization of cytokinesis, actomyosin contractile ring assembly" EXACT [GOC:obol]
synonym: "actin filament organization of cytokinesis, actomyosin contractile ring formation" RELATED [GOC:obol]
synonym: "actin filament organization of cytokinesis, actomyosin ring biosynthesis" RELATED [GOC:obol]
synonym: "actin filament organization of cytokinesis, actomyosin ring formation" RELATED [GOC:obol]
synonym: "actin filament organization of cytokinesis, contractile ring assembly" RELATED [GOC:obol]
synonym: "regulation of actin filament localization of constriction ring assembly" RELATED [GOC:obol]
synonym: "regulation of actin filament localization of contractile ring assembly" RELATED [GOC:obol]
synonym: "regulation of actin filament localization of cytokinesis, actomyosin contractile ring assembly" RELATED [GOC:obol]
synonym: "regulation of actin filament localization of cytokinesis, actomyosin contractile ring formation" RELATED [GOC:obol]
synonym: "regulation of actin filament localization of cytokinesis, actomyosin ring biosynthesis" RELATED [GOC:obol]
synonym: "regulation of actin filament localization of cytokinesis, actomyosin ring formation" RELATED [GOC:obol]
synonym: "regulation of actin filament localization of cytokinesis, contractile ring assembly" RELATED [GOC:obol]
is_a: GO:0007015 ! actin filament organization
is_a: GO:0022402 ! cell cycle process
intersection_of: GO:0007015 ! actin filament organization
intersection_of: part_of GO:0000915 ! actomyosin contractile ring assembly
relationship: part_of GO:0000915 ! actomyosin contractile ring assembly
created_by: midori
creation_date: 2011-05-17T11:48:12Z

[Term]
id: GO:2000690
name: regulation of cardiac muscle cell myoblast differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac muscle cell myoblast differentiation." [GOC:obol]
synonym: "regulation of cardiac myoblast differentiation" RELATED [GOC:obol]
synonym: "regulation of myocardial precursor cell differentiation" EXACT [GOC:obol]
is_a: GO:0045661 ! regulation of myoblast differentiation
is_a: GO:0051890 ! regulation of cardioblast differentiation
is_a: GO:2000725 ! regulation of cardiac muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060379 ! cardiac muscle cell myoblast differentiation
relationship: regulates GO:0060379 ! cardiac muscle cell myoblast differentiation
created_by: yaf
creation_date: 2011-05-25T09:08:01Z

[Term]
id: GO:2000691
name: negative regulation of cardiac muscle cell myoblast differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell myoblast differentiation." [GOC:obol]
synonym: "negative regulation of cardiac myoblast differentiation" RELATED [GOC:obol]
synonym: "negative regulation of myocardial precursor cell differentiation" EXACT [GOC:obol]
is_a: GO:0045662 ! negative regulation of myoblast differentiation
is_a: GO:0051892 ! negative regulation of cardioblast differentiation
is_a: GO:2000690 ! regulation of cardiac muscle cell myoblast differentiation
is_a: GO:2000726 ! negative regulation of cardiac muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060379 ! cardiac muscle cell myoblast differentiation
relationship: negatively_regulates GO:0060379 ! cardiac muscle cell myoblast differentiation
created_by: yaf
creation_date: 2011-05-25T09:08:06Z

[Term]
id: GO:2000692
name: negative regulation of seed maturation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of seed maturation." [GOC:obol]
is_a: GO:0048581 ! negative regulation of post-embryonic development
is_a: GO:2000034 ! regulation of seed maturation
is_a: GO:2000242 ! negative regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010431 ! seed maturation
relationship: negatively_regulates GO:0010431 ! seed maturation
created_by: dhl
creation_date: 2011-05-13T06:41:43Z

[Term]
id: GO:2000693
name: positive regulation of seed maturation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of seed maturation." [GOC:obol]
is_a: GO:0048582 ! positive regulation of post-embryonic development
is_a: GO:2000034 ! regulation of seed maturation
is_a: GO:2000243 ! positive regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010431 ! seed maturation
relationship: positively_regulates GO:0010431 ! seed maturation
created_by: dhl
creation_date: 2011-05-13T06:41:46Z

[Term]
id: GO:2000694
name: regulation of phragmoplast microtubule organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phragmoplast microtubule organization." [GOC:obol]
synonym: "regulation of phragmoplast microtubule cytoskeleton organization" EXACT [GOC:obol]
synonym: "regulation of phragmoplast microtubule organisation" EXACT [GOC:mah]
is_a: GO:0070507 ! regulation of microtubule cytoskeleton organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0080175 ! phragmoplast microtubule organization
relationship: regulates GO:0080175 ! phragmoplast microtubule organization
created_by: tanyaberardini
creation_date: 2011-05-13T09:32:27Z

[Term]
id: GO:2000696
name: regulation of epithelial cell differentiation involved in kidney development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of epithelial cell differentiation involved in kidney development." [GOC:mtg_kidney_jan10, GOC:yaf]
is_a: GO:0030856 ! regulation of epithelial cell differentiation
is_a: GO:0090183 ! regulation of kidney development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035850 ! epithelial cell differentiation involved in kidney development
relationship: regulates GO:0035850 ! epithelial cell differentiation involved in kidney development
created_by: rfoulger
creation_date: 2011-05-16T04:23:52Z

[Term]
id: GO:2000697
name: negative regulation of epithelial cell differentiation involved in kidney development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell differentiation involved in kidney development." [GOC:mtg_kidney_jan10, GOC:yaf]
is_a: GO:0030857 ! negative regulation of epithelial cell differentiation
is_a: GO:0090185 ! negative regulation of kidney development
is_a: GO:2000696 ! regulation of epithelial cell differentiation involved in kidney development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035850 ! epithelial cell differentiation involved in kidney development
relationship: negatively_regulates GO:0035850 ! epithelial cell differentiation involved in kidney development
created_by: rfoulger
creation_date: 2011-05-16T04:23:55Z

[Term]
id: GO:2000698
name: positive regulation of epithelial cell differentiation involved in kidney development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation involved in kidney development." [GOC:mtg_kidney_jan10, GOC:yaf]
is_a: GO:0030858 ! positive regulation of epithelial cell differentiation
is_a: GO:0090184 ! positive regulation of kidney development
is_a: GO:2000696 ! regulation of epithelial cell differentiation involved in kidney development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035850 ! epithelial cell differentiation involved in kidney development
relationship: positively_regulates GO:0035850 ! epithelial cell differentiation involved in kidney development
created_by: rfoulger
creation_date: 2011-05-16T04:23:57Z

[Term]
id: GO:2000699
name: fibroblast growth factor receptor signaling pathway involved in ureteric bud formation
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to the formation of the ureteric bud from the Wolffian duct." [GOC:mtg_kidney_jan10, GOC:yaf]
synonym: "FGF receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "FGF receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "FGFR signaling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "fibroblast growth factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "fibroblast growth factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol]
is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway
intersection_of: GO:0008543 ! fibroblast growth factor receptor signaling pathway
intersection_of: part_of GO:0060676 ! ureteric bud formation
relationship: part_of GO:0060676 ! ureteric bud formation
created_by: rfoulger
creation_date: 2011-05-16T04:52:14Z

[Term]
id: GO:2000700
name: positive regulation of cardiac muscle cell myoblast differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell myoblast differentiation." [GOC:obol]
synonym: "positive regulation of cardiac myoblast differentiation" RELATED [GOC:obol]
synonym: "positive regulation of myocardial precursor cell differentiation" EXACT [GOC:obol]
is_a: GO:0045663 ! positive regulation of myoblast differentiation
is_a: GO:0051891 ! positive regulation of cardioblast differentiation
is_a: GO:2000690 ! regulation of cardiac muscle cell myoblast differentiation
is_a: GO:2000727 ! positive regulation of cardiac muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060379 ! cardiac muscle cell myoblast differentiation
relationship: positively_regulates GO:0060379 ! cardiac muscle cell myoblast differentiation
created_by: yaf
creation_date: 2011-05-25T09:08:09Z

[Term]
id: GO:2000701
name: glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a glial cell-derived neurotrophic factor receptor binding to one of its physiological ligands that contributes to the formation of the ureteric bud from the Wolffian duct." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf]
synonym: "GDNF receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "glial cell derived neurotrophic factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "glial cell line-derived neurotrophic factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "glial cell-derived neurotrophic factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "glial cell-derived neurotrophic factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol]
is_a: GO:0035860 ! glial cell-derived neurotrophic factor receptor signaling pathway
intersection_of: GO:0035860 ! glial cell-derived neurotrophic factor receptor signaling pathway
intersection_of: part_of GO:0060676 ! ureteric bud formation
relationship: part_of GO:0060676 ! ureteric bud formation
created_by: yaf
creation_date: 2011-05-25T09:34:07Z

[Term]
id: GO:2000702
name: regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf]
synonym: "regulation of FGF receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "regulation of FGF receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "regulation of FGFR signaling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "regulation of fibroblast growth factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "regulation of fibroblast growth factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol]
is_a: GO:0040036 ! regulation of fibroblast growth factor receptor signaling pathway
is_a: GO:0072106 ! regulation of ureteric bud formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:2000699 ! fibroblast growth factor receptor signaling pathway involved in ureteric bud formation
relationship: regulates GO:2000699 ! fibroblast growth factor receptor signaling pathway involved in ureteric bud formation
created_by: yaf
creation_date: 2011-05-25T09:48:15Z

[Term]
id: GO:2000703
name: negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf]
synonym: "negative regulation of FGF receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "negative regulation of FGF receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "negative regulation of FGFR signaling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "negative regulation of fibroblast growth factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "negative regulation of fibroblast growth factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol]
is_a: GO:0040037 ! negative regulation of fibroblast growth factor receptor signaling pathway
is_a: GO:0045992 ! negative regulation of embryonic development
is_a: GO:0061218 ! negative regulation of mesonephros development
is_a: GO:2000702 ! regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:2000699 ! fibroblast growth factor receptor signaling pathway involved in ureteric bud formation
relationship: negatively_regulates GO:2000699 ! fibroblast growth factor receptor signaling pathway involved in ureteric bud formation
created_by: yaf
creation_date: 2011-05-25T09:48:22Z

[Term]
id: GO:2000704
name: positive regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf]
synonym: "positive regulation of FGF receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "positive regulation of FGF receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "positive regulation of FGFR signaling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "positive regulation of fibroblast growth factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "positive regulation of fibroblast growth factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol]
is_a: GO:0045743 ! positive regulation of fibroblast growth factor receptor signaling pathway
is_a: GO:0072107 ! positive regulation of ureteric bud formation
is_a: GO:2000702 ! regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:2000699 ! fibroblast growth factor receptor signaling pathway involved in ureteric bud formation
relationship: positively_regulates GO:2000699 ! fibroblast growth factor receptor signaling pathway involved in ureteric bud formation
created_by: yaf
creation_date: 2011-05-25T09:48:27Z

[Term]
id: GO:2000705
name: regulation of dense core granule biogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dense core granule biogenesis." [GOC:obol]
is_a: GO:0044087 ! regulation of cellular component biogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061110 ! dense core granule biogenesis
relationship: regulates GO:0061110 ! dense core granule biogenesis
created_by: yaf
creation_date: 2011-05-26T10:29:21Z

[Term]
id: GO:2000706
name: negative regulation of dense core granule biogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of dense core granule biogenesis." [GOC:obol]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:2000705 ! regulation of dense core granule biogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061110 ! dense core granule biogenesis
relationship: negatively_regulates GO:0061110 ! dense core granule biogenesis
created_by: yaf
creation_date: 2011-05-26T10:29:27Z

[Term]
id: GO:2000707
name: positive regulation of dense core granule biogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of dense core granule biogenesis." [GOC:obol]
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:2000705 ! regulation of dense core granule biogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061110 ! dense core granule biogenesis
relationship: positively_regulates GO:0061110 ! dense core granule biogenesis
created_by: yaf
creation_date: 2011-05-26T10:29:30Z

[Term]
id: GO:2000708
name: myosin filament organization involved in cytokinetic actomyosin contractile ring assembly
namespace: biological_process
def: "A myosin filament organization process that contributes to actomyosin contractile ring assembly during cytokinesis." [GOC:mah]
synonym: "myosin filament assembly or disassembly of constriction ring assembly" RELATED [GOC:obol]
synonym: "myosin filament assembly or disassembly of contractile ring assembly" RELATED [GOC:obol]
synonym: "myosin filament assembly or disassembly of cytokinesis, actomyosin contractile ring assembly" RELATED [GOC:obol]
synonym: "myosin filament assembly or disassembly of cytokinesis, actomyosin contractile ring formation" RELATED [GOC:obol]
synonym: "myosin filament assembly or disassembly of cytokinesis, actomyosin ring biosynthesis" RELATED [GOC:obol]
synonym: "myosin filament assembly or disassembly of cytokinesis, actomyosin ring formation" RELATED [GOC:obol]
synonym: "myosin filament assembly or disassembly of cytokinesis, contractile ring assembly" RELATED [GOC:obol]
synonym: "myosin filament organisation involved in cytokinetic actomyosin contractile ring assembly" EXACT [GOC:mah]
synonym: "myosin filament organization of constriction ring assembly" RELATED [GOC:obol]
synonym: "myosin filament organization of contractile ring assembly" EXACT [GOC:obol]
synonym: "myosin filament organization of cytokinesis, actomyosin contractile ring assembly" EXACT [GOC:obol]
synonym: "myosin filament organization of cytokinesis, actomyosin contractile ring formation" RELATED [GOC:obol]
synonym: "myosin filament organization of cytokinesis, actomyosin ring biosynthesis" RELATED [GOC:obol]
synonym: "myosin filament organization of cytokinesis, actomyosin ring formation" RELATED [GOC:obol]
synonym: "myosin filament organization of cytokinesis, contractile ring assembly" RELATED [GOC:obol]
synonym: "myosin polymerization or depolymerization of constriction ring assembly" RELATED [GOC:obol]
synonym: "myosin polymerization or depolymerization of contractile ring assembly" RELATED [GOC:obol]
synonym: "myosin polymerization or depolymerization of cytokinesis, actomyosin contractile ring assembly" RELATED [GOC:obol]
synonym: "myosin polymerization or depolymerization of cytokinesis, actomyosin contractile ring formation" RELATED [GOC:obol]
synonym: "myosin polymerization or depolymerization of cytokinesis, actomyosin ring biosynthesis" RELATED [GOC:obol]
synonym: "myosin polymerization or depolymerization of cytokinesis, actomyosin ring formation" RELATED [GOC:obol]
synonym: "myosin polymerization or depolymerization of cytokinesis, contractile ring assembly" RELATED [GOC:obol]
is_a: GO:0022402 ! cell cycle process
is_a: GO:0031033 ! myosin filament organization
intersection_of: GO:0031033 ! myosin filament organization
intersection_of: part_of GO:0000915 ! actomyosin contractile ring assembly
relationship: part_of GO:0000915 ! actomyosin contractile ring assembly
created_by: midori
creation_date: 2011-06-01T12:33:56Z

[Term]
id: GO:2000709
name: regulation of maintenance of meiotic sister chromatid cohesion, centromeric
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of maintenance of meiotic sister chromatid cohesion in the centromeric region." [GOC:mah]
synonym: "regulation of maintenance of centromeric meiotic sister chromatin cohesion" EXACT [GOC:obol]
synonym: "regulation of maintenance of meiotic sister chromatin cohesion at centromere" EXACT [GOC:obol]
synonym: "regulation of maintenance of sister chromatin cohesion at centromere at meiosis I" EXACT [GOC:obol]
is_a: GO:0034094 ! regulation of maintenance of meiotic sister chromatid cohesion
is_a: GO:0070602 ! regulation of centromeric sister chromatid cohesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035875 ! maintenance of meiotic sister chromatid cohesion, centromeric
relationship: regulates GO:0035875 ! maintenance of meiotic sister chromatid cohesion, centromeric
created_by: midori
creation_date: 2011-06-01T12:41:11Z

[Term]
id: GO:2000710
name: negative regulation of maintenance of meiotic sister chromatid cohesion, centromeric
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of meiotic sister chromatid cohesion in the centromeric region." [GOC:mah]
synonym: "negative regulation of maintenance of centromeric meiotic sister chromatin cohesion" EXACT [GOC:obol]
synonym: "negative regulation of maintenance of meiotic sister chromatin cohesion at centromere" EXACT [GOC:obol]
synonym: "negative regulation of maintenance of sister chromatin cohesion at centromere at meiosis I" EXACT [GOC:obol]
is_a: GO:0034095 ! negative regulation of maintenance of meiotic sister chromatid cohesion
is_a: GO:2000709 ! regulation of maintenance of meiotic sister chromatid cohesion, centromeric
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035875 ! maintenance of meiotic sister chromatid cohesion, centromeric
relationship: negatively_regulates GO:0035875 ! maintenance of meiotic sister chromatid cohesion, centromeric
created_by: midori
creation_date: 2011-06-01T12:41:16Z

[Term]
id: GO:2000711
name: positive regulation of maintenance of meiotic sister chromatid cohesion, centromeric
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of maintenance of meiotic sister chromatid cohesion in the centromeric region." [GOC:mah]
synonym: "positive regulation of maintenance of centromeric meiotic sister chromatin cohesion" EXACT [GOC:obol]
synonym: "positive regulation of maintenance of meiotic sister chromatin cohesion at centromere" EXACT [GOC:obol]
synonym: "positive regulation of maintenance of sister chromatin cohesion at centromere at meiosis I" EXACT [GOC:obol]
is_a: GO:0034096 ! positive regulation of maintenance of meiotic sister chromatid cohesion
is_a: GO:2000709 ! regulation of maintenance of meiotic sister chromatid cohesion, centromeric
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035875 ! maintenance of meiotic sister chromatid cohesion, centromeric
relationship: positively_regulates GO:0035875 ! maintenance of meiotic sister chromatid cohesion, centromeric
created_by: midori
creation_date: 2011-06-01T12:41:18Z

[Term]
id: GO:2000712
name: regulation of maintenance of meiotic sister chromatid cohesion, arms
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of maintenance of meiotic sister chromatid cohesion along the chromosome arms." [GOC:mah]
synonym: "regulation of maintenance of meiotic sister chromatin cohesion along arms" EXACT [GOC:obol]
synonym: "regulation of maintenance of sister chromatin cohesion along arms at meiosis I" EXACT [GOC:obol]
is_a: GO:0034094 ! regulation of maintenance of meiotic sister chromatid cohesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035876 ! maintenance of meiotic sister chromatid cohesion, arms
relationship: regulates GO:0035876 ! maintenance of meiotic sister chromatid cohesion, arms
created_by: midori
creation_date: 2011-06-01T12:45:35Z

[Term]
id: GO:2000713
name: negative regulation of maintenance of meiotic sister chromatid cohesion, arms
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of meiotic sister chromatid cohesion along the chromosome arms." [GOC:mah]
synonym: "negative regulation of maintenance of meiotic sister chromatin cohesion along arms" EXACT [GOC:obol]
synonym: "negative regulation of maintenance of sister chromatin cohesion along arms at meiosis I" EXACT [GOC:obol]
is_a: GO:0034095 ! negative regulation of maintenance of meiotic sister chromatid cohesion
is_a: GO:2000712 ! regulation of maintenance of meiotic sister chromatid cohesion, arms
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035876 ! maintenance of meiotic sister chromatid cohesion, arms
relationship: negatively_regulates GO:0035876 ! maintenance of meiotic sister chromatid cohesion, arms
created_by: midori
creation_date: 2011-06-01T12:45:39Z

[Term]
id: GO:2000714
name: positive regulation of maintenance of meiotic sister chromatid cohesion, arms
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of maintenance of meiotic sister chromatid cohesion along the chromosome arms." [GOC:mah]
synonym: "positive regulation of maintenance of meiotic sister chromatin cohesion along arms" EXACT [GOC:obol]
synonym: "positive regulation of maintenance of sister chromatin cohesion along arms at meiosis I" EXACT [GOC:obol]
is_a: GO:0034096 ! positive regulation of maintenance of meiotic sister chromatid cohesion
is_a: GO:2000712 ! regulation of maintenance of meiotic sister chromatid cohesion, arms
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035876 ! maintenance of meiotic sister chromatid cohesion, arms
relationship: positively_regulates GO:0035876 ! maintenance of meiotic sister chromatid cohesion, arms
created_by: midori
creation_date: 2011-06-01T12:45:42Z

[Term]
id: GO:2000715
name: regulation of maintenance of mitotic sister chromatid cohesion, arms
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion along the chromosome arms." [GOC:mah]
synonym: "regulation of maintenance of mitotic sister chromatin cohesion along arms" EXACT [GOC:obol]
synonym: "regulation of maintenance of sister chromatin cohesion along arms at mitosis" EXACT [GOC:obol]
is_a: GO:0034182 ! regulation of maintenance of mitotic sister chromatid cohesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071959 ! maintenance of mitotic sister chromatid cohesion, arms
relationship: regulates GO:0071959 ! maintenance of mitotic sister chromatid cohesion, arms
created_by: midori
creation_date: 2011-06-03T10:38:29Z

[Term]
id: GO:2000716
name: negative regulation of maintenance of mitotic sister chromatid cohesion, arms
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion along the chromosome arms." [GOC:mah]
synonym: "negative regulation of maintenance of mitotic sister chromatin cohesion along arms" EXACT [GOC:obol]
synonym: "negative regulation of maintenance of sister chromatin cohesion along arms at mitosis" EXACT [GOC:obol]
is_a: GO:0034183 ! negative regulation of maintenance of mitotic sister chromatid cohesion
is_a: GO:2000715 ! regulation of maintenance of mitotic sister chromatid cohesion, arms
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071959 ! maintenance of mitotic sister chromatid cohesion, arms
relationship: negatively_regulates GO:0071959 ! maintenance of mitotic sister chromatid cohesion, arms
created_by: midori
creation_date: 2011-06-03T10:38:32Z

[Term]
id: GO:2000717
name: positive regulation of maintenance of mitotic sister chromatid cohesion, arms
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion along the chromosome arms." [GOC:mah]
synonym: "positive regulation of maintenance of mitotic sister chromatin cohesion along arms" EXACT [GOC:obol]
synonym: "positive regulation of maintenance of sister chromatin cohesion along arms at mitosis" EXACT [GOC:obol]
is_a: GO:0034184 ! positive regulation of maintenance of mitotic sister chromatid cohesion
is_a: GO:2000715 ! regulation of maintenance of mitotic sister chromatid cohesion, arms
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071959 ! maintenance of mitotic sister chromatid cohesion, arms
relationship: positively_regulates GO:0071959 ! maintenance of mitotic sister chromatid cohesion, arms
created_by: midori
creation_date: 2011-06-03T10:38:35Z

[Term]
id: GO:2000718
name: regulation of maintenance of mitotic sister chromatid cohesion, centromeric
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion in the centromeric region." [GOC:mah]
synonym: "regulation of maintenance of centromeric mitotic sister chromatin cohesion" EXACT [GOC:obol]
synonym: "regulation of maintenance of mitotic sister chromatin cohesion at centromere" EXACT [GOC:obol]
synonym: "regulation of maintenance of sister chromatin cohesion at centromere at mitosis" EXACT [GOC:obol]
is_a: GO:0034182 ! regulation of maintenance of mitotic sister chromatid cohesion
is_a: GO:0070602 ! regulation of centromeric sister chromatid cohesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071960 ! maintenance of mitotic sister chromatid cohesion, centromeric
relationship: regulates GO:0071960 ! maintenance of mitotic sister chromatid cohesion, centromeric
created_by: midori
creation_date: 2011-06-03T10:41:11Z

[Term]
id: GO:2000719
name: negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion in the centromeric region." [GOC:mah]
synonym: "negative regulation of maintenance of centromeric mitotic sister chromatin cohesion" EXACT [GOC:obol]
synonym: "negative regulation of maintenance of mitotic sister chromatin cohesion at centromere" EXACT [GOC:obol]
synonym: "negative regulation of maintenance of sister chromatin cohesion at centromere at mitosis" EXACT [GOC:obol]
is_a: GO:0034183 ! negative regulation of maintenance of mitotic sister chromatid cohesion
is_a: GO:2000718 ! regulation of maintenance of mitotic sister chromatid cohesion, centromeric
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071960 ! maintenance of mitotic sister chromatid cohesion, centromeric
relationship: negatively_regulates GO:0071960 ! maintenance of mitotic sister chromatid cohesion, centromeric
created_by: midori
creation_date: 2011-06-03T10:41:14Z

[Term]
id: GO:2000720
name: positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion in the centromeric region." [GOC:mah]
synonym: "positive regulation of maintenance of centromeric mitotic sister chromatin cohesion" EXACT [GOC:obol]
synonym: "positive regulation of maintenance of mitotic sister chromatin cohesion at centromere" EXACT [GOC:obol]
synonym: "positive regulation of maintenance of sister chromatin cohesion at centromere at mitosis" EXACT [GOC:obol]
is_a: GO:0034184 ! positive regulation of maintenance of mitotic sister chromatid cohesion
is_a: GO:2000718 ! regulation of maintenance of mitotic sister chromatid cohesion, centromeric
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071960 ! maintenance of mitotic sister chromatid cohesion, centromeric
relationship: positively_regulates GO:0071960 ! maintenance of mitotic sister chromatid cohesion, centromeric
created_by: midori
creation_date: 2011-06-03T10:41:16Z

[Term]
id: GO:2000721
name: positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation
namespace: biological_process
def: "Any positive regulation of transcription from RNA polymerase II promoter that is involved in smooth muscle cell differentiation." [GOC:BHF]
synonym: "activation of global transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation" RELATED [GOC:obol]
synonym: "activation of global transcription from RNA polymerase II promoter of smooth muscle cell differentiation" RELATED [GOC:obol]
synonym: "activation of transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation" EXACT [GOC:obol]
synonym: "activation of transcription from RNA polymerase II promoter of smooth muscle cell differentiation" EXACT [GOC:obol]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation" RELATED [GOC:obol]
synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter of smooth muscle cell differentiation" RELATED [GOC:obol]
synonym: "positive regulation of global transcription from Pol II promoter of nonstriated muscle cell differentiation" RELATED [GOC:obol]
synonym: "positive regulation of global transcription from Pol II promoter of smooth muscle cell differentiation" RELATED [GOC:obol]
synonym: "positive regulation of transcription from Pol II promoter of nonstriated muscle cell differentiation" EXACT [GOC:obol]
synonym: "positive regulation of transcription from Pol II promoter of smooth muscle cell differentiation" EXACT [GOC:obol]
synonym: "positive regulation of transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation" EXACT [GOC:obol]
synonym: "positive regulation of transcription from RNA polymerase II promoter of smooth muscle cell differentiation" EXACT [GOC:obol]
synonym: "positive regulation of transcription from RNA polymerase II promoter, global of nonstriated muscle cell differentiation" RELATED [GOC:obol]
synonym: "positive regulation of transcription from RNA polymerase II promoter, global of smooth muscle cell differentiation" RELATED [GOC:obol]
synonym: "stimulation of global transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation" RELATED [GOC:obol]
synonym: "stimulation of global transcription from RNA polymerase II promoter of smooth muscle cell differentiation" RELATED [GOC:obol]
synonym: "stimulation of transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation" EXACT [GOC:obol]
synonym: "stimulation of transcription from RNA polymerase II promoter of smooth muscle cell differentiation" EXACT [GOC:obol]
synonym: "up regulation of global transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation" RELATED [GOC:obol]
synonym: "up regulation of global transcription from RNA polymerase II promoter of smooth muscle cell differentiation" RELATED [GOC:obol]
synonym: "up regulation of transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation" EXACT [GOC:obol]
synonym: "up regulation of transcription from RNA polymerase II promoter of smooth muscle cell differentiation" EXACT [GOC:obol]
synonym: "up-regulation of global transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation" RELATED [GOC:obol]
synonym: "up-regulation of global transcription from RNA polymerase II promoter of smooth muscle cell differentiation" RELATED [GOC:obol]
synonym: "up-regulation of transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation" EXACT [GOC:obol]
synonym: "up-regulation of transcription from RNA polymerase II promoter of smooth muscle cell differentiation" EXACT [GOC:obol]
synonym: "upregulation of global transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation" RELATED [GOC:obol]
synonym: "upregulation of global transcription from RNA polymerase II promoter of smooth muscle cell differentiation" EXACT [GOC:obol]
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
intersection_of: part_of GO:0051145 ! smooth muscle cell differentiation
relationship: part_of GO:0051145 ! smooth muscle cell differentiation
created_by: vk
creation_date: 2011-06-08T08:34:55Z

[Term]
id: GO:2000722
name: regulation of cardiac vascular smooth muscle cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac vascular smooth muscle cell differentiation." [GOC:BHF]
synonym: "regulation of heart vascular smooth muscle cell differentiation" EXACT [GOC:obol]
is_a: GO:1905063 ! regulation of vascular smooth muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060947 ! cardiac vascular smooth muscle cell differentiation
relationship: regulates GO:0060947 ! cardiac vascular smooth muscle cell differentiation
created_by: vk
creation_date: 2011-06-08T08:47:58Z

[Term]
id: GO:2000723
name: negative regulation of cardiac vascular smooth muscle cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac vascular smooth muscle cell differentiation." [GOC:BHF]
synonym: "negative regulation of heart vascular smooth muscle cell differentiation" EXACT [GOC:obol]
is_a: GO:1905064 ! negative regulation of vascular smooth muscle cell differentiation
is_a: GO:2000722 ! regulation of cardiac vascular smooth muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060947 ! cardiac vascular smooth muscle cell differentiation
relationship: negatively_regulates GO:0060947 ! cardiac vascular smooth muscle cell differentiation
created_by: vk
creation_date: 2011-06-08T08:48:01Z

[Term]
id: GO:2000724
name: positive regulation of cardiac vascular smooth muscle cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiac vascular smooth muscle cell differentiation." [GOC:BHF]
synonym: "positive regulation of heart vascular smooth muscle cell differentiation" EXACT [GOC:obol]
is_a: GO:1905065 ! positive regulation of vascular smooth muscle cell differentiation
is_a: GO:2000722 ! regulation of cardiac vascular smooth muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060947 ! cardiac vascular smooth muscle cell differentiation
relationship: positively_regulates GO:0060947 ! cardiac vascular smooth muscle cell differentiation
created_by: vk
creation_date: 2011-06-08T08:48:04Z

[Term]
id: GO:2000725
name: regulation of cardiac muscle cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac muscle cell differentiation." [GOC:BHF]
synonym: "regulation of cardiomyocyte differentiation" EXACT [GOC:obol]
synonym: "regulation of heart muscle cell differentiation" RELATED [GOC:obol]
is_a: GO:0051153 ! regulation of striated muscle cell differentiation
is_a: GO:0055024 ! regulation of cardiac muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0055007 ! cardiac muscle cell differentiation
relationship: regulates GO:0055007 ! cardiac muscle cell differentiation
created_by: vk
creation_date: 2011-06-08T10:51:06Z

[Term]
id: GO:2000726
name: negative regulation of cardiac muscle cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell differentiation." [GOC:BHF]
synonym: "negative regulation of cardiomyocyte differentiation" EXACT [GOC:obol]
synonym: "negative regulation of heart muscle cell differentiation" RELATED [GOC:obol]
is_a: GO:0051154 ! negative regulation of striated muscle cell differentiation
is_a: GO:0055026 ! negative regulation of cardiac muscle tissue development
is_a: GO:2000725 ! regulation of cardiac muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0055007 ! cardiac muscle cell differentiation
relationship: negatively_regulates GO:0055007 ! cardiac muscle cell differentiation
created_by: vk
creation_date: 2011-06-08T10:51:11Z

[Term]
id: GO:2000727
name: positive regulation of cardiac muscle cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell differentiation." [GOC:BHF]
synonym: "positive regulation of cardiomyocyte differentiation" EXACT [GOC:obol]
synonym: "positive regulation of heart muscle cell differentiation" RELATED [GOC:obol]
is_a: GO:0051155 ! positive regulation of striated muscle cell differentiation
is_a: GO:0055025 ! positive regulation of cardiac muscle tissue development
is_a: GO:2000725 ! regulation of cardiac muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0055007 ! cardiac muscle cell differentiation
relationship: positively_regulates GO:0055007 ! cardiac muscle cell differentiation
created_by: vk
creation_date: 2011-06-08T10:51:15Z

[Term]
id: GO:2000728
name: regulation of mRNA export from nucleus in response to heat stress
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mRNA export from nucleus in response to heat stress." [PMID:15210706]
synonym: "regulation of mRNA export from cell nucleus during heat stress" EXACT [GOC:obol]
synonym: "regulation of mRNA export from nucleus during heat stress" RELATED [GOC:obol]
is_a: GO:0010793 ! regulation of mRNA export from nucleus
is_a: GO:1900034 ! regulation of cellular response to heat
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031990 ! mRNA export from nucleus in response to heat stress
relationship: regulates GO:0031990 ! mRNA export from nucleus in response to heat stress
created_by: pr
creation_date: 2011-06-08T12:17:45Z

[Term]
id: GO:2000729
name: positive regulation of mesenchymal cell proliferation involved in ureter development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mesenchymal cell proliferation involved in ureter development." [GOC:obol]
synonym: "positive regulation of ureter mesenchymal cell proliferation" RELATED [GOC:obol]
synonym: "positive regulation of ureteral mesenchymal cell proliferation" RELATED [GOC:obol]
is_a: GO:0002053 ! positive regulation of mesenchymal cell proliferation
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0072199 ! regulation of mesenchymal cell proliferation involved in ureter development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072198 ! mesenchymal cell proliferation involved in ureter development
relationship: positively_regulates GO:0072198 ! mesenchymal cell proliferation involved in ureter development
created_by: yaf
creation_date: 2011-06-10T02:27:19Z

[Term]
id: GO:2000730
name: regulation of termination of RNA polymerase I transcription
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of termination of RNA polymerase I transcription." [GOC:obol]
synonym: "regulation of RNA polymerase I transcription termination" EXACT [GOC:obol]
synonym: "regulation of transcription termination from Pol I promoter" EXACT [GOC:obol]
synonym: "regulation of transcription termination from RNA polymerase I promoter" EXACT [GOC:obol]
is_a: GO:0006356 ! regulation of transcription from RNA polymerase I promoter
is_a: GO:0031554 ! regulation of DNA-templated transcription, termination
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006363 ! termination of RNA polymerase I transcription
relationship: regulates GO:0006363 ! termination of RNA polymerase I transcription
created_by: dph
creation_date: 2011-06-10T08:43:39Z

[Term]
id: GO:2000731
name: negative regulation of termination of RNA polymerase I transcription
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of termination of RNA polymerase I transcription." [GOC:obol]
synonym: "negative regulation of RNA polymerase I transcription termination" EXACT [GOC:obol]
synonym: "negative regulation of transcription termination from Pol I promoter" EXACT [GOC:obol]
synonym: "negative regulation of transcription termination from RNA polymerase I promoter" EXACT [GOC:obol]
is_a: GO:0016479 ! negative regulation of transcription from RNA polymerase I promoter
is_a: GO:0060567 ! negative regulation of DNA-templated transcription, termination
is_a: GO:2000730 ! regulation of termination of RNA polymerase I transcription
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006363 ! termination of RNA polymerase I transcription
relationship: negatively_regulates GO:0006363 ! termination of RNA polymerase I transcription
created_by: dph
creation_date: 2011-06-10T08:43:44Z

[Term]
id: GO:2000732
name: positive regulation of termination of RNA polymerase I transcription
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of termination of RNA polymerase I transcription." [GOC:obol]
synonym: "positive regulation of RNA polymerase I transcription termination" EXACT [GOC:obol]
synonym: "positive regulation of transcription termination from Pol I promoter" EXACT [GOC:obol]
synonym: "positive regulation of transcription termination from RNA polymerase I promoter" EXACT [GOC:obol]
is_a: GO:0045943 ! positive regulation of transcription from RNA polymerase I promoter
is_a: GO:0060566 ! positive regulation of DNA-templated transcription, termination
is_a: GO:2000730 ! regulation of termination of RNA polymerase I transcription
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006363 ! termination of RNA polymerase I transcription
relationship: positively_regulates GO:0006363 ! termination of RNA polymerase I transcription
created_by: dph
creation_date: 2011-06-10T08:43:48Z

[Term]
id: GO:2000733
name: regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation." [GOC:obol]
synonym: "regulation of GDNF receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "regulation of glial cell derived neurotrophic factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "regulation of glial cell line-derived neurotrophic factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "regulation of glial cell-derived neurotrophic factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "regulation of glial cell-derived neurotrophic factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol]
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0072106 ! regulation of ureteric bud formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:2000701 ! glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation
relationship: regulates GO:2000701 ! glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation
created_by: yaf
creation_date: 2011-06-13T11:14:40Z

[Term]
id: GO:2000734
name: negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation." [GOC:obol]
synonym: "negative regulation of GDNF receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "negative regulation of glial cell derived neurotrophic factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "negative regulation of glial cell line-derived neurotrophic factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "negative regulation of glial cell-derived neurotrophic factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0045992 ! negative regulation of embryonic development
is_a: GO:0061218 ! negative regulation of mesonephros development
is_a: GO:2000733 ! regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:2000701 ! glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation
relationship: negatively_regulates GO:2000701 ! glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation
created_by: yaf
creation_date: 2011-06-13T11:14:44Z

[Term]
id: GO:2000735
name: positive regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation." [GOC:obol]
synonym: "positive regulation of GDNF receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "positive regulation of glial cell derived neurotrophic factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "positive regulation of glial cell line-derived neurotrophic factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "positive regulation of glial cell-derived neurotrophic factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol]
synonym: "positive regulation of glial cell-derived neurotrophic factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0072107 ! positive regulation of ureteric bud formation
is_a: GO:2000733 ! regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:2000701 ! glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation
relationship: positively_regulates GO:2000701 ! glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation
created_by: yaf
creation_date: 2011-06-13T11:14:46Z

[Term]
id: GO:2000736
name: regulation of stem cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of stem cell differentiation." [GOC:obol]
is_a: GO:0045595 ! regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048863 ! stem cell differentiation
relationship: regulates GO:0048863 ! stem cell differentiation
created_by: yaf
creation_date: 2011-06-14T02:05:16Z

[Term]
id: GO:2000737
name: negative regulation of stem cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of stem cell differentiation." [GOC:obol]
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:2000736 ! regulation of stem cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048863 ! stem cell differentiation
relationship: negatively_regulates GO:0048863 ! stem cell differentiation
created_by: yaf
creation_date: 2011-06-14T02:05:20Z

[Term]
id: GO:2000738
name: positive regulation of stem cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of stem cell differentiation." [GOC:obol]
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:2000736 ! regulation of stem cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048863 ! stem cell differentiation
relationship: positively_regulates GO:0048863 ! stem cell differentiation
created_by: yaf
creation_date: 2011-06-14T02:05:23Z

[Term]
id: GO:2000739
name: regulation of mesenchymal stem cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesenchymal stem cell differentiation." [GOC:obol]
is_a: GO:2000736 ! regulation of stem cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072497 ! mesenchymal stem cell differentiation
relationship: regulates GO:0072497 ! mesenchymal stem cell differentiation
created_by: yaf
creation_date: 2011-06-14T02:31:27Z

[Term]
id: GO:2000740
name: negative regulation of mesenchymal stem cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal stem cell differentiation." [GOC:obol]
is_a: GO:2000737 ! negative regulation of stem cell differentiation
is_a: GO:2000739 ! regulation of mesenchymal stem cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072497 ! mesenchymal stem cell differentiation
relationship: negatively_regulates GO:0072497 ! mesenchymal stem cell differentiation
created_by: yaf
creation_date: 2011-06-14T02:31:31Z

[Term]
id: GO:2000741
name: positive regulation of mesenchymal stem cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mesenchymal stem cell differentiation." [GOC:obol]
is_a: GO:2000738 ! positive regulation of stem cell differentiation
is_a: GO:2000739 ! regulation of mesenchymal stem cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072497 ! mesenchymal stem cell differentiation
relationship: positively_regulates GO:0072497 ! mesenchymal stem cell differentiation
created_by: yaf
creation_date: 2011-06-14T02:31:34Z

[Term]
id: GO:2000742
name: regulation of anterior head development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of anterior head development." [GOC:obol]
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097065 ! anterior head development
relationship: regulates GO:0097065 ! anterior head development
created_by: yaf
creation_date: 2011-06-14T09:44:09Z

[Term]
id: GO:2000743
name: negative regulation of anterior head development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of anterior head development." [GOC:obol]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:2000742 ! regulation of anterior head development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097065 ! anterior head development
relationship: negatively_regulates GO:0097065 ! anterior head development
created_by: yaf
creation_date: 2011-06-14T09:44:14Z

[Term]
id: GO:2000744
name: positive regulation of anterior head development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of anterior head development." [GOC:obol]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:2000742 ! regulation of anterior head development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097065 ! anterior head development
relationship: positively_regulates GO:0097065 ! anterior head development
created_by: yaf
creation_date: 2011-06-14T09:44:17Z

[Term]
id: GO:2000745
name: obsolete positive regulation of transcription from RNA polymerase III promoter involved in smooth muscle cell differentiation
namespace: biological_process
def: "OBSOLETE. Any positive regulation of transcription from RNA polymerase III promoter that is involved in smooth muscle cell differentiation." [GOC:BHF]
comment: This term was made obsolete because it was added in error.
synonym: "activation of transcription from RNA polymerase III promoter of nonstriated muscle cell differentiation" RELATED [GOC:obol]
synonym: "activation of transcription from RNA polymerase III promoter of smooth muscle cell differentiation" RELATED [GOC:obol]
synonym: "positive regulation of transcription from Pol III promoter of nonstriated muscle cell differentiation" EXACT [GOC:obol]
synonym: "positive regulation of transcription from Pol III promoter of smooth muscle cell differentiation" EXACT [GOC:obol]
synonym: "positive regulation of transcription from RNA polymerase III promoter involved in smooth muscle cell differentiation" EXACT []
synonym: "positive regulation of transcription from RNA polymerase III promoter of nonstriated muscle cell differentiation" EXACT [GOC:obol]
synonym: "positive regulation of transcription from RNA polymerase III promoter of smooth muscle cell differentiation" EXACT [GOC:obol]
synonym: "stimulation of transcription from RNA polymerase III promoter of nonstriated muscle cell differentiation" RELATED [GOC:obol]
synonym: "stimulation of transcription from RNA polymerase III promoter of smooth muscle cell differentiation" RELATED [GOC:obol]
synonym: "up regulation of transcription from RNA polymerase III promoter of nonstriated muscle cell differentiation" EXACT [GOC:obol]
synonym: "up regulation of transcription from RNA polymerase III promoter of smooth muscle cell differentiation" EXACT [GOC:obol]
synonym: "up-regulation of transcription from RNA polymerase III promoter of nonstriated muscle cell differentiation" EXACT [GOC:obol]
synonym: "up-regulation of transcription from RNA polymerase III promoter of smooth muscle cell differentiation" EXACT [GOC:obol]
synonym: "upregulation of transcription from RNA polymerase III promoter of nonstriated muscle cell differentiation" EXACT [GOC:obol]
synonym: "upregulation of transcription from RNA polymerase III promoter of smooth muscle cell differentiation" EXACT [GOC:obol]
is_obsolete: true
created_by: rfoulger
creation_date: 2011-06-15T10:03:19Z

[Term]
id: GO:2000746
name: regulation of defecation rhythm
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of defecation rhythm." [GOC:kmv]
synonym: "regulation of defecation behavior" RELATED [GOC:obol]
synonym: "regulation of defecation cycle" EXACT [GOC:obol]
synonym: "regulation of defecation motor program" EXACT [GOC:obol]
synonym: "regulation of DMP" EXACT [GOC:obol]
is_a: GO:2000292 ! regulation of defecation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035882 ! defecation rhythm
relationship: regulates GO:0035882 ! defecation rhythm
created_by: rfoulger
creation_date: 2011-06-15T03:23:07Z

[Term]
id: GO:2000747
name: negative regulation of defecation rhythm
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of defecation rhythm." [GOC:kmv]
synonym: "negative regulation of defecation behavior" RELATED [GOC:obol]
synonym: "negative regulation of defecation cycle" EXACT [GOC:obol]
synonym: "negative regulation of defecation motor program" EXACT [GOC:obol]
synonym: "negative regulation of DMP" EXACT [GOC:obol]
is_a: GO:2000293 ! negative regulation of defecation
is_a: GO:2000746 ! regulation of defecation rhythm
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035882 ! defecation rhythm
relationship: negatively_regulates GO:0035882 ! defecation rhythm
created_by: rfoulger
creation_date: 2011-06-15T03:23:10Z

[Term]
id: GO:2000748
name: positive regulation of defecation rhythm
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of defecation rhythm." [GOC:kmv]
synonym: "positive regulation of defecation behavior" RELATED [GOC:obol]
synonym: "positive regulation of defecation cycle" EXACT [GOC:obol]
synonym: "positive regulation of defecation motor program" EXACT [GOC:obol]
synonym: "positive regulation of DMP" EXACT [GOC:obol]
is_a: GO:2000294 ! positive regulation of defecation
is_a: GO:2000746 ! regulation of defecation rhythm
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035882 ! defecation rhythm
relationship: positively_regulates GO:0035882 ! defecation rhythm
created_by: rfoulger
creation_date: 2011-06-15T03:23:13Z

[Term]
id: GO:2000749
name: positive regulation of chromatin silencing at rDNA
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chromatin silencing at rDNA." [PMID:10899127]
synonym: "positive regulation of chromatin silencing at ribosomal DNA" EXACT [GOC:obol]
synonym: "positive regulation of heterochromatic silencing at rDNA" EXACT [GOC:obol]
synonym: "positive regulation of rDNA chromatin silencing" EXACT [GOC:obol]
is_a: GO:0031937 ! positive regulation of chromatin silencing
is_a: GO:0061187 ! regulation of chromatin silencing at rDNA
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000183 ! chromatin silencing at rDNA
relationship: positively_regulates GO:0000183 ! chromatin silencing at rDNA
created_by: pr
creation_date: 2011-06-16T09:43:55Z

[Term]
id: GO:2000750
name: negative regulation of establishment or maintenance of bipolar cell polarity regulating cell shape
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment or maintenance of bipolar cell polarity regulating cell shape." [GOC:mah]
is_a: GO:2000100 ! regulation of establishment or maintenance of bipolar cell polarity regulating cell shape
is_a: GO:2000770 ! negative regulation of establishment or maintenance of cell polarity regulating cell shape
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061246 ! establishment or maintenance of bipolar cell polarity regulating cell shape
relationship: negatively_regulates GO:0061246 ! establishment or maintenance of bipolar cell polarity regulating cell shape
created_by: midori
creation_date: 2011-06-16T11:51:49Z

[Term]
id: GO:2000751
name: histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore
namespace: biological_process
def: "Any histone H3-T3 phosphorylation that is involved in chromosome passenger complex localization to kinetochore." [GOC:obol]
synonym: "histone H3-T3 phosphorylation of chromosomal passenger complex localization to kinetochore" EXACT [GOC:obol]
synonym: "histone H3-T3 phosphorylation of chromosome passenger complex localisation to kinetochore" RELATED [GOC:obol]
synonym: "histone H3-T3 phosphorylation of chromosome passenger complex localization to kinetochore" EXACT [GOC:obol]
synonym: "histone H3-T3 phosphorylation of CPC complex localization to kinetochore" EXACT [GOC:obol]
synonym: "histone H3-T3 phosphorylation of CPC localization to kinetochore" EXACT [GOC:obol]
is_a: GO:0072355 ! histone H3-T3 phosphorylation
intersection_of: GO:0072355 ! histone H3-T3 phosphorylation
intersection_of: part_of GO:0072356 ! chromosome passenger complex localization to kinetochore
relationship: part_of GO:0072356 ! chromosome passenger complex localization to kinetochore
created_by: vw
creation_date: 2011-06-16T12:56:29Z

[Term]
id: GO:2000752
name: regulation of glucosylceramide catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glucosylceramide catabolic process." [GOC:BHF]
synonym: "regulation of glucosylceramide breakdown" EXACT [GOC:obol]
synonym: "regulation of glucosylceramide catabolism" EXACT [GOC:obol]
synonym: "regulation of glucosylceramide degradation" EXACT [GOC:obol]
is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:0034248 ! regulation of cellular amide metabolic process
is_a: GO:0050994 ! regulation of lipid catabolic process
is_a: GO:1905038 ! regulation of membrane lipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006680 ! glucosylceramide catabolic process
relationship: regulates GO:0006680 ! glucosylceramide catabolic process
created_by: rl
creation_date: 2011-06-16T03:12:04Z

[Term]
id: GO:2000753
name: positive regulation of glucosylceramide catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glucosylceramide catabolic process." [GOC:BHF]
synonym: "positive regulation of glucosylceramide breakdown" EXACT [GOC:obol]
synonym: "positive regulation of glucosylceramide catabolism" EXACT [GOC:obol]
synonym: "positive regulation of glucosylceramide degradation" EXACT [GOC:obol]
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:0034250 ! positive regulation of cellular amide metabolic process
is_a: GO:0050996 ! positive regulation of lipid catabolic process
is_a: GO:2000752 ! regulation of glucosylceramide catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006680 ! glucosylceramide catabolic process
relationship: positively_regulates GO:0006680 ! glucosylceramide catabolic process
created_by: rl
creation_date: 2011-06-16T03:12:09Z

[Term]
id: GO:2000754
name: regulation of sphingomyelin catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sphingomyelin catabolic process." [GOC:BHF]
synonym: "regulation of sphingomyelin breakdown" EXACT [GOC:obol]
synonym: "regulation of sphingomyelin catabolism" EXACT [GOC:obol]
synonym: "regulation of sphingomyelin degradation" EXACT [GOC:obol]
is_a: GO:0033238 ! regulation of cellular amine metabolic process
is_a: GO:0034248 ! regulation of cellular amide metabolic process
is_a: GO:0060696 ! regulation of phospholipid catabolic process
is_a: GO:1905038 ! regulation of membrane lipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006685 ! sphingomyelin catabolic process
relationship: regulates GO:0006685 ! sphingomyelin catabolic process
created_by: rl
creation_date: 2011-06-16T03:17:30Z

[Term]
id: GO:2000755
name: positive regulation of sphingomyelin catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sphingomyelin catabolic process." [GOC:BHF]
synonym: "positive regulation of sphingomyelin breakdown" EXACT [GOC:obol]
synonym: "positive regulation of sphingomyelin catabolism" EXACT [GOC:obol]
synonym: "positive regulation of sphingomyelin degradation" EXACT [GOC:obol]
is_a: GO:0033240 ! positive regulation of cellular amine metabolic process
is_a: GO:0034250 ! positive regulation of cellular amide metabolic process
is_a: GO:0060697 ! positive regulation of phospholipid catabolic process
is_a: GO:2000754 ! regulation of sphingomyelin catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006685 ! sphingomyelin catabolic process
relationship: positively_regulates GO:0006685 ! sphingomyelin catabolic process
created_by: rl
creation_date: 2011-06-16T03:17:35Z

[Term]
id: GO:2000756
name: regulation of peptidyl-lysine acetylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of peptidyl-lysine acetylation." [GOC:obol]
is_a: GO:1901983 ! regulation of protein acetylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0018394 ! peptidyl-lysine acetylation
relationship: regulates GO:0018394 ! peptidyl-lysine acetylation
created_by: yaf
creation_date: 2011-06-16T09:51:26Z

[Term]
id: GO:2000757
name: negative regulation of peptidyl-lysine acetylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-lysine acetylation." [GOC:obol]
is_a: GO:1901984 ! negative regulation of protein acetylation
is_a: GO:2000756 ! regulation of peptidyl-lysine acetylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0018394 ! peptidyl-lysine acetylation
relationship: negatively_regulates GO:0018394 ! peptidyl-lysine acetylation
created_by: yaf
creation_date: 2011-06-16T09:51:31Z

[Term]
id: GO:2000758
name: positive regulation of peptidyl-lysine acetylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of peptidyl-lysine acetylation." [GOC:obol]
is_a: GO:1901985 ! positive regulation of protein acetylation
is_a: GO:2000756 ! regulation of peptidyl-lysine acetylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0018394 ! peptidyl-lysine acetylation
relationship: positively_regulates GO:0018394 ! peptidyl-lysine acetylation
created_by: yaf
creation_date: 2011-06-16T09:51:35Z

[Term]
id: GO:2000759
name: regulation of N-terminal peptidyl-lysine acetylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of N-terminal peptidyl-lysine acetylation." [GOC:obol]
is_a: GO:2000756 ! regulation of peptidyl-lysine acetylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0018076 ! N-terminal peptidyl-lysine acetylation
relationship: regulates GO:0018076 ! N-terminal peptidyl-lysine acetylation
created_by: yaf
creation_date: 2011-06-17T12:58:16Z

[Term]
id: GO:2000760
name: negative regulation of N-terminal peptidyl-lysine acetylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of N-terminal peptidyl-lysine acetylation." [GOC:obol]
is_a: GO:2000757 ! negative regulation of peptidyl-lysine acetylation
is_a: GO:2000759 ! regulation of N-terminal peptidyl-lysine acetylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0018076 ! N-terminal peptidyl-lysine acetylation
relationship: negatively_regulates GO:0018076 ! N-terminal peptidyl-lysine acetylation
created_by: yaf
creation_date: 2011-06-17T12:58:20Z

[Term]
id: GO:2000761
name: positive regulation of N-terminal peptidyl-lysine acetylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of N-terminal peptidyl-lysine acetylation." [GOC:obol]
is_a: GO:2000758 ! positive regulation of peptidyl-lysine acetylation
is_a: GO:2000759 ! regulation of N-terminal peptidyl-lysine acetylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0018076 ! N-terminal peptidyl-lysine acetylation
relationship: positively_regulates GO:0018076 ! N-terminal peptidyl-lysine acetylation
created_by: yaf
creation_date: 2011-06-17T12:58:24Z

[Term]
id: GO:2000762
name: regulation of phenylpropanoid metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phenylpropanoid metabolic process." [GOC:obol]
synonym: "regulation of phenylpropanoid metabolism" EXACT [GOC:obol]
is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:0043455 ! regulation of secondary metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009698 ! phenylpropanoid metabolic process
relationship: regulates GO:0009698 ! phenylpropanoid metabolic process
created_by: tanyaberardini
creation_date: 2011-06-17T06:13:43Z

[Term]
id: GO:2000763
name: positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process
namespace: biological_process
def: "Any positive regulation of transcription from RNA polymerase II promoter that is involved in norepinephrine biosynthetic process." [GOC:BHF]
synonym: "positive regulation of transcription from Pol II promoter involved in levarterenol biosynthesis" EXACT [GOC:obol]
synonym: "positive regulation of transcription from Pol II promoter involved in levarterenol biosynthetic process" EXACT [GOC:obol]
synonym: "positive regulation of transcription from Pol II promoter involved in noradrenaline biosynthesis" EXACT [GOC:obol]
synonym: "positive regulation of transcription from Pol II promoter involved in noradrenaline biosynthetic process" EXACT [GOC:obol]
synonym: "positive regulation of transcription from Pol II promoter involved in norepinephrine anabolism" EXACT [GOC:obol]
synonym: "positive regulation of transcription from Pol II promoter involved in norepinephrine biosynthesis" EXACT [GOC:obol]
synonym: "positive regulation of transcription from Pol II promoter involved in norepinephrine biosynthetic process" EXACT [GOC:obol]
synonym: "positive regulation of transcription from Pol II promoter involved in norepinephrine formation" EXACT [GOC:obol]
synonym: "positive regulation of transcription from Pol II promoter involved in norepinephrine synthesis" EXACT [GOC:obol]
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
intersection_of: part_of GO:0042421 ! norepinephrine biosynthetic process
relationship: part_of GO:0042421 ! norepinephrine biosynthetic process
created_by: vk
creation_date: 2011-06-18T04:14:58Z

[Term]
id: GO:2000764
name: positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis." [GOC:BHF]
synonym: "positive regulation of semaphorin-plexin signalling pathway involved in outflow tract morphogenesis" EXACT [GOC:obol]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000826 ! regulation of heart morphogenesis
is_a: GO:2001262 ! positive regulation of semaphorin-plexin signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071527 ! semaphorin-plexin signaling pathway involved in outflow tract morphogenesis
relationship: positively_regulates GO:0071527 ! semaphorin-plexin signaling pathway involved in outflow tract morphogenesis
created_by: vk
creation_date: 2011-06-18T04:26:00Z

[Term]
id: GO:2000765
name: regulation of cytoplasmic translation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cytoplasmic translation." [GOC:obol]
is_a: GO:0006417 ! regulation of translation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002181 ! cytoplasmic translation
relationship: regulates GO:0002181 ! cytoplasmic translation
created_by: vw
creation_date: 2011-06-20T10:39:19Z

[Term]
id: GO:2000766
name: negative regulation of cytoplasmic translation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translation." [GOC:obol]
is_a: GO:0017148 ! negative regulation of translation
is_a: GO:2000765 ! regulation of cytoplasmic translation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002181 ! cytoplasmic translation
relationship: negatively_regulates GO:0002181 ! cytoplasmic translation
created_by: vw
creation_date: 2011-06-20T10:39:23Z

[Term]
id: GO:2000767
name: positive regulation of cytoplasmic translation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cytoplasmic translation." [GOC:obol]
is_a: GO:0045727 ! positive regulation of translation
is_a: GO:2000765 ! regulation of cytoplasmic translation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002181 ! cytoplasmic translation
relationship: positively_regulates GO:0002181 ! cytoplasmic translation
created_by: vw
creation_date: 2011-06-20T10:39:26Z

[Term]
id: GO:2000768
name: positive regulation of nephron tubule epithelial cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of nephron tubule epithelial cell differentiation." [GOC:obol]
is_a: GO:0072182 ! regulation of nephron tubule epithelial cell differentiation
is_a: GO:2000698 ! positive regulation of epithelial cell differentiation involved in kidney development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072160 ! nephron tubule epithelial cell differentiation
relationship: positively_regulates GO:0072160 ! nephron tubule epithelial cell differentiation
created_by: yaf
creation_date: 2011-06-22T11:55:06Z

[Term]
id: GO:2000769
name: regulation of establishment or maintenance of cell polarity regulating cell shape
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of establishment or maintenance of cell polarity regulating cell shape." [GOC:mah]
is_a: GO:0008360 ! regulation of cell shape
is_a: GO:0032878 ! regulation of establishment or maintenance of cell polarity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071963 ! establishment or maintenance of cell polarity regulating cell shape
relationship: regulates GO:0071963 ! establishment or maintenance of cell polarity regulating cell shape
created_by: midori
creation_date: 2011-06-22T01:56:49Z

[Term]
id: GO:2000770
name: negative regulation of establishment or maintenance of cell polarity regulating cell shape
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment or maintenance of cell polarity regulating cell shape." [GOC:mah]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:2000769 ! regulation of establishment or maintenance of cell polarity regulating cell shape
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071963 ! establishment or maintenance of cell polarity regulating cell shape
relationship: negatively_regulates GO:0071963 ! establishment or maintenance of cell polarity regulating cell shape
created_by: midori
creation_date: 2011-06-22T01:56:53Z

[Term]
id: GO:2000771
name: positive regulation of establishment or maintenance of cell polarity regulating cell shape
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment or maintenance of cell polarity regulating cell shape." [GOC:mah]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:2000769 ! regulation of establishment or maintenance of cell polarity regulating cell shape
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071963 ! establishment or maintenance of cell polarity regulating cell shape
relationship: positively_regulates GO:0071963 ! establishment or maintenance of cell polarity regulating cell shape
created_by: midori
creation_date: 2011-06-22T01:56:55Z

[Term]
id: GO:2000772
name: regulation of cellular senescence
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular senescence." [GOC:BHF]
is_a: GO:0080135 ! regulation of cellular response to stress
is_a: GO:0090342 ! regulation of cell aging
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0090398 ! cellular senescence
relationship: regulates GO:0090398 ! cellular senescence
created_by: rfoulger
creation_date: 2011-06-22T01:57:04Z

[Term]
id: GO:2000773
name: negative regulation of cellular senescence
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular senescence." [GOC:BHF]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:0090344 ! negative regulation of cell aging
is_a: GO:2000772 ! regulation of cellular senescence
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0090398 ! cellular senescence
relationship: negatively_regulates GO:0090398 ! cellular senescence
created_by: rfoulger
creation_date: 2011-06-22T01:57:08Z

[Term]
id: GO:2000774
name: positive regulation of cellular senescence
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellular senescence." [GOC:BHF]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:0090343 ! positive regulation of cell aging
is_a: GO:2000772 ! regulation of cellular senescence
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0090398 ! cellular senescence
relationship: positively_regulates GO:0090398 ! cellular senescence
created_by: rfoulger
creation_date: 2011-06-22T01:57:12Z

[Term]
id: GO:2000775
name: histone H3-S10 phosphorylation involved in chromosome condensation
namespace: biological_process
def: "Any histone H3-S10 phosphorylation that is involved in chromosome condensation." [GOC:obol]
synonym: "histone H3 phosphorylation at S10 of chromosome condensation" EXACT [GOC:obol]
synonym: "histone H3-S10 phosphorylation of chromosome condensation" EXACT [GOC:obol]
synonym: "histone H3S10 phosphorylation of chromosome condensation" EXACT [GOC:obol]
is_a: GO:0043987 ! histone H3-S10 phosphorylation
intersection_of: GO:0043987 ! histone H3-S10 phosphorylation
intersection_of: part_of GO:0030261 ! chromosome condensation
relationship: part_of GO:0030261 ! chromosome condensation
created_by: midori
creation_date: 2011-06-22T03:58:00Z

[Term]
id: GO:2000776
name: histone H4 acetylation involved in response to DNA damage stimulus
namespace: biological_process
def: "Any histone H4 acetylation that is involved in a response to DNA damage stimulus." [GOC:mah]
synonym: "histone H4 acetylation of cellular DNA damage response" EXACT [GOC:obol]
synonym: "histone H4 acetylation of cellular response to DNA damage stimulus" EXACT [GOC:obol]
synonym: "histone H4 acetylation of DNA damage response" EXACT [GOC:obol]
synonym: "histone H4 acetylation of response to DNA damage stimulus" EXACT [GOC:obol]
synonym: "histone H4 acetylation of response to genotoxic stress" EXACT [GOC:obol]
is_a: GO:0043967 ! histone H4 acetylation
intersection_of: GO:0043967 ! histone H4 acetylation
intersection_of: part_of GO:0006974 ! cellular response to DNA damage stimulus
relationship: part_of GO:0006974 ! cellular response to DNA damage stimulus
created_by: midori
creation_date: 2011-06-22T04:00:54Z

[Term]
id: GO:2000777
name: positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia
namespace: biological_process
def: "Any positive regulation of proteasomal ubiquitin-dependent protein catabolic process that is involved in a cellular response to hypoxia." [GOC:mah]
synonym: "positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxic stress" EXACT [GOC:obol]
synonym: "positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to lowered oxygen tension" EXACT [GOC:obol]
is_a: GO:0032436 ! positive regulation of proteasomal ubiquitin-dependent protein catabolic process
intersection_of: GO:0032436 ! positive regulation of proteasomal ubiquitin-dependent protein catabolic process
intersection_of: part_of GO:0071456 ! cellular response to hypoxia
relationship: part_of GO:0071456 ! cellular response to hypoxia
created_by: midori
creation_date: 2011-06-22T04:07:20Z

[Term]
id: GO:2000778
name: positive regulation of interleukin-6 secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of interleukin-6 secretion." [GOC:BHF]
synonym: "positive regulation of IL-6 secretion" EXACT [GOC:obol]
is_a: GO:0032755 ! positive regulation of interleukin-6 production
is_a: GO:0050715 ! positive regulation of cytokine secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072604 ! interleukin-6 secretion
relationship: positively_regulates GO:0072604 ! interleukin-6 secretion
created_by: vk
creation_date: 2011-06-22T08:27:45Z

[Term]
id: GO:2000779
name: regulation of double-strand break repair
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of double-strand break repair." [GOC:BHF]
is_a: GO:0006282 ! regulation of DNA repair
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006302 ! double-strand break repair
relationship: regulates GO:0006302 ! double-strand break repair
created_by: rfoulger
creation_date: 2011-06-23T09:28:02Z

[Term]
id: GO:2000780
name: negative regulation of double-strand break repair
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of double-strand break repair." [GOC:BHF]
is_a: GO:0045738 ! negative regulation of DNA repair
is_a: GO:2000779 ! regulation of double-strand break repair
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006302 ! double-strand break repair
relationship: negatively_regulates GO:0006302 ! double-strand break repair
created_by: rfoulger
creation_date: 2011-06-23T09:28:08Z

[Term]
id: GO:2000781
name: positive regulation of double-strand break repair
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of double-strand break repair." [GOC:BHF]
is_a: GO:0045739 ! positive regulation of DNA repair
is_a: GO:2000779 ! regulation of double-strand break repair
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006302 ! double-strand break repair
relationship: positively_regulates GO:0006302 ! double-strand break repair
created_by: rfoulger
creation_date: 2011-06-23T09:28:13Z

[Term]
id: GO:2000782
name: regulation of establishment of cell polarity regulating cell shape
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of establishment of cell polarity regulating cell shape." [GOC:Mah]
is_a: GO:2000114 ! regulation of establishment of cell polarity
is_a: GO:2000769 ! regulation of establishment or maintenance of cell polarity regulating cell shape
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071964 ! establishment of cell polarity regulating cell shape
relationship: regulates GO:0071964 ! establishment of cell polarity regulating cell shape
created_by: midori
creation_date: 2011-06-23T12:17:38Z

[Term]
id: GO:2000783
name: negative regulation of establishment of cell polarity regulating cell shape
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of cell polarity regulating cell shape." [GOC:Mah]
is_a: GO:2000770 ! negative regulation of establishment or maintenance of cell polarity regulating cell shape
is_a: GO:2000782 ! regulation of establishment of cell polarity regulating cell shape
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071964 ! establishment of cell polarity regulating cell shape
relationship: negatively_regulates GO:0071964 ! establishment of cell polarity regulating cell shape
created_by: midori
creation_date: 2011-06-23T12:17:44Z

[Term]
id: GO:2000784
name: positive regulation of establishment of cell polarity regulating cell shape
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment of cell polarity regulating cell shape." [GOC:Mah]
is_a: GO:2000771 ! positive regulation of establishment or maintenance of cell polarity regulating cell shape
is_a: GO:2000782 ! regulation of establishment of cell polarity regulating cell shape
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071964 ! establishment of cell polarity regulating cell shape
relationship: positively_regulates GO:0071964 ! establishment of cell polarity regulating cell shape
created_by: midori
creation_date: 2011-06-23T12:17:48Z

[Term]
id: GO:2000785
name: regulation of autophagosome assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of autophagosome assembly." [GOC:autophagy, GOC:BHF]
synonym: "regulation of autophagic vacuole assembly" EXACT [GOC:autophagy]
synonym: "regulation of autophagic vacuole formation" RELATED [GOC:obol]
synonym: "regulation of autophagosome biosynthesis" EXACT [GOC:obol]
synonym: "regulation of autophagosome formation" EXACT [GOC:obol]
synonym: "regulation of PAS formation" RELATED [GOC:obol]
is_a: GO:0016241 ! regulation of macroautophagy
is_a: GO:0044088 ! regulation of vacuole organization
is_a: GO:1902115 ! regulation of organelle assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000045 ! autophagosome assembly
relationship: regulates GO:0000045 ! autophagosome assembly
created_by: rl
creation_date: 2011-06-24T11:19:08Z

[Term]
id: GO:2000786
name: positive regulation of autophagosome assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of autophagic vacuole assembly." [GOC:autophagy, GOC:BHF]
synonym: "positive regulation of autophagic vacuole assembly" EXACT [GOC:autophagy]
synonym: "positive regulation of autophagic vacuole formation" RELATED [GOC:obol]
synonym: "positive regulation of autophagosome biosynthesis" EXACT [GOC:obol]
synonym: "positive regulation of autophagosome formation" EXACT [GOC:obol]
synonym: "positive regulation of PAS formation" RELATED [GOC:obol]
is_a: GO:0016239 ! positive regulation of macroautophagy
is_a: GO:0044090 ! positive regulation of vacuole organization
is_a: GO:1902117 ! positive regulation of organelle assembly
is_a: GO:2000785 ! regulation of autophagosome assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000045 ! autophagosome assembly
relationship: positively_regulates GO:0000045 ! autophagosome assembly
created_by: rl
creation_date: 2011-06-24T11:19:12Z

[Term]
id: GO:2000787
name: regulation of venous endothelial cell fate commitment
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of venous endothelial cell fate commitment." [PMID:11585794]
is_a: GO:0010453 ! regulation of cell fate commitment
is_a: GO:0045601 ! regulation of endothelial cell differentiation
is_a: GO:1901342 ! regulation of vasculature development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060845 ! venous endothelial cell fate commitment
relationship: regulates GO:0060845 ! venous endothelial cell fate commitment
created_by: rfoulger
creation_date: 2011-06-24T01:26:12Z

[Term]
id: GO:2000788
name: negative regulation of venous endothelial cell fate commitment
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of venous endothelial cell fate commitment." [PMID:11585794]
is_a: GO:0010454 ! negative regulation of cell fate commitment
is_a: GO:0045602 ! negative regulation of endothelial cell differentiation
is_a: GO:1901343 ! negative regulation of vasculature development
is_a: GO:2000787 ! regulation of venous endothelial cell fate commitment
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060845 ! venous endothelial cell fate commitment
relationship: negatively_regulates GO:0060845 ! venous endothelial cell fate commitment
created_by: rfoulger
creation_date: 2011-06-24T01:26:16Z

[Term]
id: GO:2000789
name: positive regulation of venous endothelial cell fate commitment
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of venous endothelial cell fate commitment." [PMID:11585794]
is_a: GO:0010455 ! positive regulation of cell fate commitment
is_a: GO:0045603 ! positive regulation of endothelial cell differentiation
is_a: GO:1904018 ! positive regulation of vasculature development
is_a: GO:2000787 ! regulation of venous endothelial cell fate commitment
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060845 ! venous endothelial cell fate commitment
relationship: positively_regulates GO:0060845 ! venous endothelial cell fate commitment
created_by: rfoulger
creation_date: 2011-06-24T01:26:19Z

[Term]
id: GO:2000790
name: regulation of mesenchymal cell proliferation involved in lung development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation involved in lung development." [PMID:21513708]
is_a: GO:0010464 ! regulation of mesenchymal cell proliferation
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060916 ! mesenchymal cell proliferation involved in lung development
relationship: regulates GO:0060916 ! mesenchymal cell proliferation involved in lung development
created_by: pr
creation_date: 2011-06-24T01:53:50Z

[Term]
id: GO:2000791
name: negative regulation of mesenchymal cell proliferation involved in lung development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell proliferation involved in lung development." [PMID:21513708]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0072201 ! negative regulation of mesenchymal cell proliferation
is_a: GO:2000790 ! regulation of mesenchymal cell proliferation involved in lung development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060916 ! mesenchymal cell proliferation involved in lung development
relationship: negatively_regulates GO:0060916 ! mesenchymal cell proliferation involved in lung development
created_by: pr
creation_date: 2011-06-24T01:53:53Z

[Term]
id: GO:2000792
name: positive regulation of mesenchymal cell proliferation involved in lung development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mesenchymal cell proliferation involved in lung development." [PMID:21513708]
is_a: GO:0002053 ! positive regulation of mesenchymal cell proliferation
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000790 ! regulation of mesenchymal cell proliferation involved in lung development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060916 ! mesenchymal cell proliferation involved in lung development
relationship: positively_regulates GO:0060916 ! mesenchymal cell proliferation involved in lung development
created_by: pr
creation_date: 2011-06-24T01:53:56Z

[Term]
id: GO:2000793
name: cell proliferation involved in heart valve development
namespace: biological_process
def: "Any cell proliferation that is involved in heart valve development." [GOC:BHF]
synonym: "cell proliferation of cardiac valve development" EXACT [GOC:obol]
synonym: "cell proliferation of heart valve development" EXACT [GOC:obol]
is_a: GO:0008283 ! cell proliferation
intersection_of: GO:0008283 ! cell proliferation
intersection_of: part_of GO:0003170 ! heart valve development
relationship: part_of GO:0003170 ! heart valve development
created_by: rfoulger
creation_date: 2011-06-24T03:12:15Z

[Term]
id: GO:2000794
name: regulation of epithelial cell proliferation involved in lung morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis." [PMID:21513708]
is_a: GO:0050678 ! regulation of epithelial cell proliferation
is_a: GO:2000027 ! regulation of organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060502 ! epithelial cell proliferation involved in lung morphogenesis
relationship: regulates GO:0060502 ! epithelial cell proliferation involved in lung morphogenesis
created_by: pr
creation_date: 2011-06-25T07:22:38Z

[Term]
id: GO:2000795
name: negative regulation of epithelial cell proliferation involved in lung morphogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis." [PMID:21513708]
is_a: GO:0050680 ! negative regulation of epithelial cell proliferation
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000794 ! regulation of epithelial cell proliferation involved in lung morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060502 ! epithelial cell proliferation involved in lung morphogenesis
relationship: negatively_regulates GO:0060502 ! epithelial cell proliferation involved in lung morphogenesis
created_by: pr
creation_date: 2011-06-25T07:22:42Z

[Term]
id: GO:2000796
name: Notch signaling pathway involved in negative regulation of venous endothelial cell fate commitment
namespace: biological_process
def: "Any Notch signaling pathway that is involved in negative regulation of venous endothelial cell fate commitment." [PMID:11585794]
synonym: "N signaling pathway involved in negative regulation of venous endothelial cell fate commitment" EXACT [GOC:obol]
synonym: "Notch receptor signaling pathway involved in negative regulation of venous endothelial cell fate commitment" EXACT [GOC:obol]
synonym: "Notch receptor signalling pathway involved in negative regulation of venous endothelial cell fate commitment" EXACT [GOC:obol]
synonym: "Notch signalling pathway involved in negative regulation of venous endothelial cell fate commitment" EXACT [GOC:obol]
synonym: "Notch-receptor signaling pathway involved in negative regulation of venous endothelial cell fate commitment" EXACT [GOC:obol]
synonym: "Notch-receptor signalling pathway involved in negative regulation of venous endothelial cell fate commitment" EXACT [GOC:obol]
is_a: GO:0007219 ! Notch signaling pathway
intersection_of: GO:0007219 ! Notch signaling pathway
intersection_of: part_of GO:2000788 ! negative regulation of venous endothelial cell fate commitment
relationship: part_of GO:2000788 ! negative regulation of venous endothelial cell fate commitment
created_by: rfoulger
creation_date: 2011-06-27T09:07:42Z

[Term]
id: GO:2000797
name: regulation of amniotic stem cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of amniotic stem cell differentiation." [GOC:obol]
is_a: GO:2000026 ! regulation of multicellular organismal development
is_a: GO:2000739 ! regulation of mesenchymal stem cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097086 ! amniotic stem cell differentiation
relationship: regulates GO:0097086 ! amniotic stem cell differentiation
created_by: yaf
creation_date: 2011-06-29T02:18:59Z

[Term]
id: GO:2000798
name: negative regulation of amniotic stem cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of amniotic stem cell differentiation." [GOC:obol]
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000740 ! negative regulation of mesenchymal stem cell differentiation
is_a: GO:2000797 ! regulation of amniotic stem cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097086 ! amniotic stem cell differentiation
relationship: negatively_regulates GO:0097086 ! amniotic stem cell differentiation
created_by: yaf
creation_date: 2011-06-29T02:19:03Z

[Term]
id: GO:2000799
name: positive regulation of amniotic stem cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of amniotic stem cell differentiation." [GOC:obol]
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000741 ! positive regulation of mesenchymal stem cell differentiation
is_a: GO:2000797 ! regulation of amniotic stem cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097086 ! amniotic stem cell differentiation
relationship: positively_regulates GO:0097086 ! amniotic stem cell differentiation
created_by: yaf
creation_date: 2011-06-29T02:19:06Z

[Term]
id: GO:2000800
name: regulation of endocardial cushion to mesenchymal transition involved in heart valve formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endocardial cushion to mesenchymal transition involved in heart valve formation." [GOC:BHF]
synonym: "regulation of endocardial cushion to mesenchymal transition involved in valve formation" EXACT [GOC:obol]
is_a: GO:0010717 ! regulation of epithelial to mesenchymal transition
is_a: GO:2000826 ! regulation of heart morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003199 ! endocardial cushion to mesenchymal transition involved in heart valve formation
relationship: regulates GO:0003199 ! endocardial cushion to mesenchymal transition involved in heart valve formation
created_by: rfoulger
creation_date: 2011-07-01T12:31:18Z

[Term]
id: GO:2000801
name: negative regulation of endocardial cushion to mesenchymal transition involved in heart valve formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of endocardial cushion to mesenchymal transition involved in heart valve formation." [GOC:BHF]
synonym: "negative regulation of endocardial cushion to mesenchymal transition involved in valve formation" EXACT [GOC:obol]
is_a: GO:0010719 ! negative regulation of epithelial to mesenchymal transition
is_a: GO:2000800 ! regulation of endocardial cushion to mesenchymal transition involved in heart valve formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003199 ! endocardial cushion to mesenchymal transition involved in heart valve formation
relationship: negatively_regulates GO:0003199 ! endocardial cushion to mesenchymal transition involved in heart valve formation
created_by: rfoulger
creation_date: 2011-07-01T12:31:22Z

[Term]
id: GO:2000802
name: positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endocardial cushion to mesenchymal transition involved in heart valve formation." [GOC:BHF]
synonym: "positive regulation of endocardial cushion to mesenchymal transition involved in valve formation" EXACT [GOC:obol]
is_a: GO:0010718 ! positive regulation of epithelial to mesenchymal transition
is_a: GO:2000800 ! regulation of endocardial cushion to mesenchymal transition involved in heart valve formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003199 ! endocardial cushion to mesenchymal transition involved in heart valve formation
relationship: positively_regulates GO:0003199 ! endocardial cushion to mesenchymal transition involved in heart valve formation
created_by: rfoulger
creation_date: 2011-07-01T12:31:25Z

[Term]
id: GO:2000803
name: endosomal signal transduction
namespace: biological_process
def: "The process in which a signal is passed on to downstream components located at the endosome. Endosomes can provide important intracellular signaling platforms and provide spatial and temporal control over signal transduction." [GOC:bf, GOC:signaling, PMID:15084302, PMID:17662591]
synonym: "endosome-based signaling" EXACT [PMID:17662591]
synonym: "signaling cascade in endosome" RELATED [GOC:obol]
synonym: "signaling from endosome" EXACT [PMID:17662591]
synonym: "signaling pathway in endosome" RELATED [GOC:obol]
synonym: "signalling cascade in endosome" RELATED [GOC:obol]
synonym: "signalling pathway in endosome" RELATED [GOC:obol]
is_a: GO:0035556 ! intracellular signal transduction
intersection_of: GO:0007165 ! signal transduction
intersection_of: occurs_in GO:0005768 ! endosome
relationship: occurs_in GO:0005768 ! endosome
created_by: rfoulger
creation_date: 2011-07-01T03:45:12Z

[Term]
id: GO:2000804
name: regulation of termination of RNA polymerase II transcription, poly(A)-coupled
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of termination of RNA polymerase II transcription, poly(A)-coupled." [GOC:obol]
synonym: "regulation of termination of RNA polymerase II transcription, polyadenylation-coupled" RELATED []
synonym: "regulation of transcription termination from Pol II promoter, poly(A) coupled" RELATED [GOC:obol]
synonym: "regulation of transcription termination from Pol II promoter, RNA polymerase(A) coupled" RELATED [GOC:obol]
is_a: GO:1904594 ! regulation of termination of RNA polymerase II transcription
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030846 ! termination of RNA polymerase II transcription, poly(A)-coupled
relationship: regulates GO:0030846 ! termination of RNA polymerase II transcription, poly(A)-coupled
created_by: pr
creation_date: 2011-07-04T08:41:27Z

[Term]
id: GO:2000805
name: negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of termination of RNA polymerase II transcription, poly(A)-coupled." [GOC:obol]
synonym: "negative regulation of termination of RNA polymerase II transcription, polyadenylation-coupled" RELATED []
synonym: "negative regulation of transcription termination from Pol II promoter, poly(A) coupled" RELATED [GOC:obol]
synonym: "negative regulation of transcription termination from Pol II promoter, RNA polymerase(A) coupled" RELATED [GOC:obol]
is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
is_a: GO:0060567 ! negative regulation of DNA-templated transcription, termination
is_a: GO:2000804 ! regulation of termination of RNA polymerase II transcription, poly(A)-coupled
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030846 ! termination of RNA polymerase II transcription, poly(A)-coupled
relationship: negatively_regulates GO:0030846 ! termination of RNA polymerase II transcription, poly(A)-coupled
created_by: pr
creation_date: 2011-07-04T08:41:34Z

[Term]
id: GO:2000806
name: positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of termination of RNA polymerase II transcription, poly(A)-coupled." [GOC:obol]
synonym: "positive regulation of termination of RNA polymerase II transcription, polyadenylation-coupled" RELATED []
synonym: "positive regulation of transcription termination from Pol II promoter, poly(A) coupled" RELATED [GOC:obol]
synonym: "positive regulation of transcription termination from Pol II promoter, RNA polymerase(A) coupled" RELATED [GOC:obol]
is_a: GO:1904595 ! positive regulation of termination of RNA polymerase II transcription
is_a: GO:2000804 ! regulation of termination of RNA polymerase II transcription, poly(A)-coupled
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030846 ! termination of RNA polymerase II transcription, poly(A)-coupled
relationship: positively_regulates GO:0030846 ! termination of RNA polymerase II transcription, poly(A)-coupled
created_by: pr
creation_date: 2011-07-04T08:41:39Z

[Term]
id: GO:2000807
name: regulation of synaptic vesicle clustering
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synaptic vesicle clustering." [PMID:21513708]
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0051049 ! regulation of transport
is_a: GO:0060341 ! regulation of cellular localization
is_a: GO:1901629 ! regulation of presynaptic membrane organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097091 ! synaptic vesicle clustering
relationship: regulates GO:0097091 ! synaptic vesicle clustering
created_by: pr
creation_date: 2011-07-06T09:50:30Z

[Term]
id: GO:2000808
name: negative regulation of synaptic vesicle clustering
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle clustering." [PMID:21513708]
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:1901630 ! negative regulation of presynaptic membrane organization
is_a: GO:2000807 ! regulation of synaptic vesicle clustering
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097091 ! synaptic vesicle clustering
relationship: negatively_regulates GO:0097091 ! synaptic vesicle clustering
created_by: pr
creation_date: 2011-07-06T09:50:34Z

[Term]
id: GO:2000809
name: positive regulation of synaptic vesicle clustering
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of synaptic vesicle clustering." [PMID:21513708]
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:1901631 ! positive regulation of presynaptic membrane organization
is_a: GO:2000807 ! regulation of synaptic vesicle clustering
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097091 ! synaptic vesicle clustering
relationship: positively_regulates GO:0097091 ! synaptic vesicle clustering
created_by: pr
creation_date: 2011-07-06T09:50:37Z

[Term]
id: GO:2000810
name: regulation of bicellular tight junction assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tight junction assembly." [GOC:BHF]
synonym: "regulation of tight junction formation" EXACT [GOC:obol]
is_a: GO:1901888 ! regulation of cell junction assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070830 ! bicellular tight junction assembly
relationship: regulates GO:0070830 ! bicellular tight junction assembly
created_by: vk
creation_date: 2011-07-06T01:08:28Z

[Term]
id: GO:2000811
name: negative regulation of anoikis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of anoikis." [GOC:obol]
synonym: "negative regulation of detachment induced cell death" EXACT [GOC:obol]
synonym: "negative regulation of suspension induced apoptosis" EXACT [GOC:obol]
is_a: GO:0043066 ! negative regulation of apoptotic process
is_a: GO:2000209 ! regulation of anoikis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043276 ! anoikis
relationship: negatively_regulates GO:0043276 ! anoikis
created_by: pr
creation_date: 2011-07-07T09:42:20Z

[Term]
id: GO:2000812
name: regulation of barbed-end actin filament capping
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of barbed-end actin filament capping." [GOC:BHF]
synonym: "regulation of barbed-end actin capping activity" EXACT [GOC:obol]
synonym: "regulation of barbed-end F-actin capping activity" EXACT [GOC:obol]
synonym: "regulation of plus-end actin filament capping activity" EXACT [GOC:obol]
synonym: "regulation of plus-end F-actin capping activity" EXACT [GOC:obol]
is_a: GO:0030833 ! regulation of actin filament polymerization
is_a: GO:0030834 ! regulation of actin filament depolymerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051016 ! barbed-end actin filament capping
relationship: regulates GO:0051016 ! barbed-end actin filament capping
created_by: rl
creation_date: 2011-07-07T04:08:13Z

[Term]
id: GO:2000813
name: negative regulation of barbed-end actin filament capping
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of barbed-end actin filament capping." [GOC:BHF]
synonym: "negative regulation of barbed-end actin capping activity" EXACT [GOC:obol]
synonym: "negative regulation of barbed-end F-actin capping activity" EXACT [GOC:obol]
synonym: "negative regulation of plus-end actin filament capping activity" EXACT [GOC:obol]
synonym: "negative regulation of plus-end F-actin capping activity" EXACT [GOC:obol]
is_a: GO:0030836 ! positive regulation of actin filament depolymerization
is_a: GO:0030838 ! positive regulation of actin filament polymerization
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:2000812 ! regulation of barbed-end actin filament capping
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051016 ! barbed-end actin filament capping
relationship: negatively_regulates GO:0051016 ! barbed-end actin filament capping
created_by: rl
creation_date: 2011-07-07T04:08:18Z

[Term]
id: GO:2000814
name: positive regulation of barbed-end actin filament capping
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of barbed-end actin filament capping." [GOC:BHF]
synonym: "positive regulation of barbed-end actin capping activity" EXACT [GOC:obol]
synonym: "positive regulation of barbed-end F-actin capping activity" EXACT [GOC:obol]
synonym: "positive regulation of plus-end actin filament capping activity" EXACT [GOC:obol]
synonym: "positive regulation of plus-end F-actin capping activity" EXACT [GOC:obol]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:2000812 ! regulation of barbed-end actin filament capping
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051016 ! barbed-end actin filament capping
relationship: positively_regulates GO:0051016 ! barbed-end actin filament capping
created_by: rl
creation_date: 2011-07-07T04:08:23Z

[Term]
id: GO:2000815
name: regulation of mRNA stability involved in response to oxidative stress
namespace: biological_process
def: "A process of regulation of mRNA stability that is involved in a response to oxidative stress." [GOC:obol]
is_a: GO:0010610 ! regulation of mRNA stability involved in response to stress
intersection_of: GO:0043488 ! regulation of mRNA stability
intersection_of: part_of GO:0006979 ! response to oxidative stress
relationship: part_of GO:0006979 ! response to oxidative stress
created_by: midori
creation_date: 2011-07-11T04:40:56Z

[Term]
id: GO:2000816
name: negative regulation of mitotic sister chromatid separation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic sister chromatid separation." [GOC:obol]
synonym: "negative regulation of chromosome separation during mitosis" RELATED [GOC:obol]
synonym: "negative regulation of mitotic chromosome separation" RELATED [GOC:obol]
synonym: "negative regulation of mitotic sister chromatid resolution" EXACT [GOC:obol]
synonym: "negative regulation of sister chromatid separation during mitosis" EXACT [GOC:obol]
is_a: GO:0010965 ! regulation of mitotic sister chromatid separation
is_a: GO:0033048 ! negative regulation of mitotic sister chromatid segregation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051306 ! mitotic sister chromatid separation
relationship: negatively_regulates GO:0051306 ! mitotic sister chromatid separation
created_by: midori
creation_date: 2011-07-11T04:45:06Z

[Term]
id: GO:2000817
name: regulation of histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore
namespace: biological_process
def: "Any regulation of histone H3-T3 phosphorylation that is involved in chromosome passenger complex localization to kinetochore." [GOC:obol]
synonym: "regulation of histone H3-T3 phosphorylation involved in chromosomal passenger complex localization to kinetochore" EXACT [GOC:obol]
synonym: "regulation of histone H3-T3 phosphorylation involved in chromosome passenger complex localisation to kinetochore" RELATED [GOC:obol]
synonym: "regulation of histone H3-T3 phosphorylation involved in CPC complex localization to kinetochore" EXACT [GOC:obol]
synonym: "regulation of histone H3-T3 phosphorylation involved in CPC localization to kinetochore" EXACT [GOC:obol]
is_a: GO:2000281 ! regulation of histone H3-T3 phosphorylation
intersection_of: GO:2000281 ! regulation of histone H3-T3 phosphorylation
intersection_of: part_of GO:0072356 ! chromosome passenger complex localization to kinetochore
relationship: part_of GO:0072356 ! chromosome passenger complex localization to kinetochore
created_by: midori
creation_date: 2011-07-12T11:37:40Z

[Term]
id: GO:2000818
name: negative regulation of myoblast proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of myoblast proliferation." [GOC:obol]
is_a: GO:0008285 ! negative regulation of cell proliferation
is_a: GO:2000291 ! regulation of myoblast proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051450 ! myoblast proliferation
relationship: negatively_regulates GO:0051450 ! myoblast proliferation
created_by: pr
creation_date: 2011-07-12T03:06:04Z

[Term]
id: GO:2000819
name: regulation of nucleotide-excision repair
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nucleotide-excision repair." [GOC:jp, PMID:18836076]
synonym: "regulation of interstrand crosslink repair" RELATED [GOC:obol]
synonym: "regulation of intrastrand cross-link repair" RELATED [GOC:obol]
synonym: "regulation of NER" EXACT [GOC:obol]
synonym: "regulation of pyrimidine-dimer repair, DNA damage excision" EXACT [GOC:obol]
is_a: GO:0006282 ! regulation of DNA repair
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006289 ! nucleotide-excision repair
relationship: regulates GO:0006289 ! nucleotide-excision repair
created_by: pr
creation_date: 2011-07-13T08:55:39Z

[Term]
id: GO:2000820
name: negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation
namespace: biological_process
def: "Any negative regulation of transcription from RNA polymerase II promoter that is involved in smooth muscle cell differentiation." [GOC:BHF]
synonym: "down regulation of global transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation" RELATED [GOC:obol]
synonym: "down regulation of global transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation" RELATED [GOC:obol]
synonym: "down regulation of transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation" EXACT [GOC:obol]
synonym: "down regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation" EXACT [GOC:obol]
synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation" RELATED [GOC:obol]
synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation" RELATED [GOC:obol]
synonym: "down-regulation of transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation" EXACT [GOC:obol]
synonym: "down-regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation" EXACT [GOC:obol]
synonym: "downregulation of global transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation" RELATED [GOC:obol]
synonym: "downregulation of global transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation" RELATED [GOC:obol]
synonym: "downregulation of transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation" EXACT [GOC:obol]
synonym: "downregulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation" EXACT [GOC:obol]
synonym: "inhibition of global transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation" RELATED [GOC:obol]
synonym: "inhibition of global transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation" RELATED [GOC:obol]
synonym: "inhibition of transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation" EXACT [GOC:obol]
synonym: "inhibition of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation" EXACT [GOC:obol]
synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation" RELATED [GOC:obol]
synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation" RELATED [GOC:obol]
synonym: "negative regulation of global transcription from Pol II promoter involved in nonstriated muscle cell differentiation" RELATED [GOC:obol]
synonym: "negative regulation of global transcription from Pol II promoter involved in smooth muscle cell differentiation" RELATED [GOC:obol]
synonym: "negative regulation of transcription from Pol II promoter involved in nonstriated muscle cell differentiation" EXACT [GOC:obol]
synonym: "negative regulation of transcription from Pol II promoter involved in smooth muscle cell differentiation" EXACT [GOC:obol]
synonym: "negative regulation of transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation" EXACT [GOC:obol]
synonym: "negative regulation of transcription from RNA polymerase II promoter, global involved in nonstriated muscle cell differentiation" RELATED [GOC:obol]
synonym: "negative regulation of transcription from RNA polymerase II promoter, global involved in smooth muscle cell differentiation" RELATED [GOC:obol]
is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
intersection_of: part_of GO:0051145 ! smooth muscle cell differentiation
relationship: part_of GO:0051145 ! smooth muscle cell differentiation
created_by: rfoulger
creation_date: 2011-07-14T08:25:05Z

[Term]
id: GO:2000821
name: regulation of grooming behavior
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of grooming behavior." [GOC:BHF]
synonym: "regulation of grooming behaviour" EXACT [GOC:obol]
is_a: GO:0050795 ! regulation of behavior
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007625 ! grooming behavior
relationship: regulates GO:0007625 ! grooming behavior
created_by: rl
creation_date: 2011-07-14T04:48:12Z

[Term]
id: GO:2000822
name: regulation of behavioral fear response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of behavioral fear response." [GOC:BHF]
synonym: "regulation of behavioural fear response" EXACT [GOC:obol]
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0050795 ! regulation of behavior
is_a: GO:1903365 ! regulation of fear response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001662 ! behavioral fear response
relationship: regulates GO:0001662 ! behavioral fear response
created_by: rl
creation_date: 2011-07-14T04:50:47Z

[Term]
id: GO:2000823
name: regulation of androgen receptor activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of androgen receptor activity." [GOC:obol]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0010469 ! regulation of receptor activity
is_a: GO:0051090 ! regulation of sequence-specific DNA binding transcription factor activity
is_a: GO:0060765 ! regulation of androgen receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004882 ! androgen receptor activity
relationship: regulates GO:0004882 ! androgen receptor activity
created_by: yaf
creation_date: 2011-07-15T10:56:08Z

[Term]
id: GO:2000824
name: negative regulation of androgen receptor activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of androgen receptor activity." [GOC:obol]
is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
is_a: GO:0043433 ! negative regulation of sequence-specific DNA binding transcription factor activity
is_a: GO:0060766 ! negative regulation of androgen receptor signaling pathway
is_a: GO:2000272 ! negative regulation of receptor activity
is_a: GO:2000823 ! regulation of androgen receptor activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004882 ! androgen receptor activity
relationship: negatively_regulates GO:0004882 ! androgen receptor activity
created_by: yaf
creation_date: 2011-07-15T10:56:12Z

[Term]
id: GO:2000825
name: positive regulation of androgen receptor activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of androgen receptor activity." [GOC:obol]
is_a: GO:0033145 ! positive regulation of intracellular steroid hormone receptor signaling pathway
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
is_a: GO:0051091 ! positive regulation of sequence-specific DNA binding transcription factor activity
is_a: GO:2000273 ! positive regulation of receptor activity
is_a: GO:2000823 ! regulation of androgen receptor activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004882 ! androgen receptor activity
relationship: positively_regulates GO:0004882 ! androgen receptor activity
created_by: yaf
creation_date: 2011-07-15T10:56:14Z

[Term]
id: GO:2000826
name: regulation of heart morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of heart morphogenesis." [GOC:BHF]
synonym: "regulation of cardiac morphogenesis" RELATED [GOC:obol]
is_a: GO:2000027 ! regulation of organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003007 ! heart morphogenesis
relationship: regulates GO:0003007 ! heart morphogenesis
created_by: vk
creation_date: 2011-07-19T10:08:58Z

[Term]
id: GO:2000827
name: mitochondrial RNA surveillance
namespace: biological_process
def: "The set of processes involved in identifying and degrading defective or aberrant RNAs that takes place in the mitochondrion." [PMID:19864255]
synonym: "aberrant RNA catabolic process in mitochondria" EXACT [GOC:obol]
synonym: "aberrant RNA catabolic process in mitochondrion" EXACT [GOC:obol]
synonym: "RNA quality control in mitochondria" EXACT [GOC:obol]
synonym: "RNA quality control in mitochondrion" EXACT [GOC:obol]
synonym: "RNA surveillance in mitochondria" EXACT [GOC:obol]
is_a: GO:0000957 ! mitochondrial RNA catabolic process
is_a: GO:0071026 ! cytoplasmic RNA surveillance
intersection_of: GO:0071025 ! RNA surveillance
intersection_of: occurs_in GO:0005739 ! mitochondrion
relationship: occurs_in GO:0005739 ! mitochondrion
created_by: rfoulger
creation_date: 2011-07-20T01:33:23Z

[Term]
id: GO:2000828
name: regulation of parathyroid hormone secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of parathyroid hormone secretion." [GOC:obol]
synonym: "regulation of parathormone secretion" EXACT [GOC:obol]
synonym: "regulation of parathyrin secretion" EXACT [GOC:obol]
synonym: "regulation of PTH secretion" EXACT [GOC:obol]
is_a: GO:0044060 ! regulation of endocrine process
is_a: GO:0046883 ! regulation of hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035898 ! parathyroid hormone secretion
relationship: regulates GO:0035898 ! parathyroid hormone secretion
created_by: rfoulger
creation_date: 2011-07-26T08:37:53Z

[Term]
id: GO:2000829
name: negative regulation of parathyroid hormone secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of parathyroid hormone secretion." [GOC:obol]
synonym: "negative regulation of parathormone secretion" EXACT [GOC:obol]
synonym: "negative regulation of parathyrin secretion" EXACT [GOC:obol]
synonym: "negative regulation of PTH secretion" EXACT [GOC:obol]
is_a: GO:0046888 ! negative regulation of hormone secretion
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000828 ! regulation of parathyroid hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035898 ! parathyroid hormone secretion
relationship: negatively_regulates GO:0035898 ! parathyroid hormone secretion
created_by: rfoulger
creation_date: 2011-07-26T08:37:57Z

[Term]
id: GO:2000830
name: positive regulation of parathyroid hormone secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of parathyroid hormone secretion." [GOC:obol]
synonym: "positive regulation of parathormone secretion" EXACT [GOC:obol]
synonym: "positive regulation of parathyrin secretion" EXACT [GOC:obol]
synonym: "positive regulation of PTH secretion" EXACT [GOC:obol]
is_a: GO:0046887 ! positive regulation of hormone secretion
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000828 ! regulation of parathyroid hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035898 ! parathyroid hormone secretion
relationship: positively_regulates GO:0035898 ! parathyroid hormone secretion
created_by: rfoulger
creation_date: 2011-07-26T08:38:00Z

[Term]
id: GO:2000831
name: regulation of steroid hormone secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of steroid hormone secretion." [GOC:sl]
is_a: GO:0032368 ! regulation of lipid transport
is_a: GO:0044060 ! regulation of endocrine process
is_a: GO:0046883 ! regulation of hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035929 ! steroid hormone secretion
relationship: regulates GO:0035929 ! steroid hormone secretion
created_by: rfoulger
creation_date: 2011-07-26T08:38:46Z

[Term]
id: GO:2000832
name: negative regulation of steroid hormone secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of steroid hormone secretion." [GOC:sl]
is_a: GO:0032369 ! negative regulation of lipid transport
is_a: GO:0046888 ! negative regulation of hormone secretion
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000831 ! regulation of steroid hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035929 ! steroid hormone secretion
relationship: negatively_regulates GO:0035929 ! steroid hormone secretion
created_by: rfoulger
creation_date: 2011-07-26T08:38:50Z

[Term]
id: GO:2000833
name: positive regulation of steroid hormone secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of steroid hormone secretion." [GOC:sl]
is_a: GO:0032370 ! positive regulation of lipid transport
is_a: GO:0046887 ! positive regulation of hormone secretion
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000831 ! regulation of steroid hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035929 ! steroid hormone secretion
relationship: positively_regulates GO:0035929 ! steroid hormone secretion
created_by: rfoulger
creation_date: 2011-07-26T08:38:51Z

[Term]
id: GO:2000834
name: regulation of androgen secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of androgen secretion." [GOC:sl]
is_a: GO:2000831 ! regulation of steroid hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035935 ! androgen secretion
relationship: regulates GO:0035935 ! androgen secretion
created_by: rfoulger
creation_date: 2011-07-26T08:39:45Z

[Term]
id: GO:2000835
name: negative regulation of androgen secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of androgen secretion." [GOC:sl]
is_a: GO:2000832 ! negative regulation of steroid hormone secretion
is_a: GO:2000834 ! regulation of androgen secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035935 ! androgen secretion
relationship: negatively_regulates GO:0035935 ! androgen secretion
created_by: rfoulger
creation_date: 2011-07-26T08:39:48Z

[Term]
id: GO:2000836
name: positive regulation of androgen secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of androgen secretion." [GOC:sl]
is_a: GO:2000833 ! positive regulation of steroid hormone secretion
is_a: GO:2000834 ! regulation of androgen secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035935 ! androgen secretion
relationship: positively_regulates GO:0035935 ! androgen secretion
created_by: rfoulger
creation_date: 2011-07-26T08:39:51Z

[Term]
id: GO:2000837
name: regulation of androstenedione secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of androstenedione secretion." [GOC:sl]
synonym: "regulation of androst-4-ene-3,17-dione secretion" EXACT [GOC:obol]
is_a: GO:2000834 ! regulation of androgen secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035941 ! androstenedione secretion
relationship: regulates GO:0035941 ! androstenedione secretion
created_by: rfoulger
creation_date: 2011-07-26T08:40:36Z

[Term]
id: GO:2000838
name: negative regulation of androstenedione secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of androstenedione secretion." [GOC:sl]
synonym: "negative regulation of androst-4-ene-3,17-dione secretion" EXACT [GOC:obol]
is_a: GO:2000835 ! negative regulation of androgen secretion
is_a: GO:2000837 ! regulation of androstenedione secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035941 ! androstenedione secretion
relationship: negatively_regulates GO:0035941 ! androstenedione secretion
created_by: rfoulger
creation_date: 2011-07-26T08:40:40Z

[Term]
id: GO:2000839
name: positive regulation of androstenedione secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of androstenedione secretion." [GOC:sl]
synonym: "positive regulation of androst-4-ene-3,17-dione secretion" EXACT [GOC:obol]
is_a: GO:2000836 ! positive regulation of androgen secretion
is_a: GO:2000837 ! regulation of androstenedione secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035941 ! androstenedione secretion
relationship: positively_regulates GO:0035941 ! androstenedione secretion
created_by: rfoulger
creation_date: 2011-07-26T08:40:42Z

[Term]
id: GO:2000840
name: regulation of dehydroepiandrosterone secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dehydroepiandrosterone secretion." [GOC:sl]
synonym: "regulation of 3beta-hydroxyandrost-5-en-17-one secretion" EXACT [GOC:obol]
synonym: "regulation of dehydroisoandrosterone secretion" EXACT [GOC:obol]
synonym: "regulation of DHEA secretion" EXACT [GOC:obol]
is_a: GO:2000834 ! regulation of androgen secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035942 ! dehydroepiandrosterone secretion
relationship: regulates GO:0035942 ! dehydroepiandrosterone secretion
created_by: rfoulger
creation_date: 2011-07-26T08:41:29Z

[Term]
id: GO:2000841
name: negative regulation of dehydroepiandrosterone secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of dehydroepiandrosterone secretion." [GOC:sl]
synonym: "negative regulation of 3beta-hydroxyandrost-5-en-17-one secretion" EXACT [GOC:obol]
synonym: "negative regulation of dehydroisoandrosterone secretion" EXACT [GOC:obol]
synonym: "negative regulation of DHEA secretion" EXACT [GOC:obol]
is_a: GO:2000835 ! negative regulation of androgen secretion
is_a: GO:2000840 ! regulation of dehydroepiandrosterone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035942 ! dehydroepiandrosterone secretion
relationship: negatively_regulates GO:0035942 ! dehydroepiandrosterone secretion
created_by: rfoulger
creation_date: 2011-07-26T08:41:33Z

[Term]
id: GO:2000842
name: positive regulation of dehydroepiandrosterone secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of dehydroepiandrosterone secretion." [GOC:sl]
synonym: "positive regulation of 3beta-hydroxyandrost-5-en-17-one secretion" EXACT [GOC:obol]
synonym: "positive regulation of dehydroisoandrosterone secretion" EXACT [GOC:obol]
synonym: "positive regulation of DHEA secretion" EXACT [GOC:obol]
is_a: GO:2000836 ! positive regulation of androgen secretion
is_a: GO:2000840 ! regulation of dehydroepiandrosterone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035942 ! dehydroepiandrosterone secretion
relationship: positively_regulates GO:0035942 ! dehydroepiandrosterone secretion
created_by: rfoulger
creation_date: 2011-07-26T08:41:36Z

[Term]
id: GO:2000843
name: regulation of testosterone secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of testosterone secretion." [GOC:sl]
is_a: GO:2000834 ! regulation of androgen secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035936 ! testosterone secretion
relationship: regulates GO:0035936 ! testosterone secretion
created_by: rfoulger
creation_date: 2011-07-26T08:42:29Z

[Term]
id: GO:2000844
name: negative regulation of testosterone secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of testosterone secretion." [GOC:sl]
is_a: GO:2000835 ! negative regulation of androgen secretion
is_a: GO:2000843 ! regulation of testosterone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035936 ! testosterone secretion
relationship: negatively_regulates GO:0035936 ! testosterone secretion
created_by: rfoulger
creation_date: 2011-07-26T08:42:33Z

[Term]
id: GO:2000845
name: positive regulation of testosterone secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of testosterone secretion." [GOC:sl]
is_a: GO:2000836 ! positive regulation of androgen secretion
is_a: GO:2000843 ! regulation of testosterone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035936 ! testosterone secretion
relationship: positively_regulates GO:0035936 ! testosterone secretion
created_by: rfoulger
creation_date: 2011-07-26T08:42:36Z

[Term]
id: GO:2000846
name: regulation of corticosteroid hormone secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of corticosteroid hormone secretion." [GOC:sl]
synonym: "regulation of corticosteroid secretion" RELATED [GOC:obol]
is_a: GO:2000831 ! regulation of steroid hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035930 ! corticosteroid hormone secretion
relationship: regulates GO:0035930 ! corticosteroid hormone secretion
created_by: rfoulger
creation_date: 2011-07-26T08:43:38Z

[Term]
id: GO:2000847
name: negative regulation of corticosteroid hormone secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of corticosteroid hormone secretion." [GOC:sl]
synonym: "negative regulation of corticosteroid secretion" RELATED [GOC:obol]
is_a: GO:2000832 ! negative regulation of steroid hormone secretion
is_a: GO:2000846 ! regulation of corticosteroid hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035930 ! corticosteroid hormone secretion
relationship: negatively_regulates GO:0035930 ! corticosteroid hormone secretion
created_by: rfoulger
creation_date: 2011-07-26T08:43:42Z

[Term]
id: GO:2000848
name: positive regulation of corticosteroid hormone secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of corticosteroid hormone secretion." [GOC:sl]
synonym: "positive regulation of corticosteroid secretion" RELATED [GOC:obol]
is_a: GO:2000833 ! positive regulation of steroid hormone secretion
is_a: GO:2000846 ! regulation of corticosteroid hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035930 ! corticosteroid hormone secretion
relationship: positively_regulates GO:0035930 ! corticosteroid hormone secretion
created_by: rfoulger
creation_date: 2011-07-26T08:43:45Z

[Term]
id: GO:2000849
name: regulation of glucocorticoid secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glucocorticoid secretion." [GOC:sl]
is_a: GO:2000846 ! regulation of corticosteroid hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035933 ! glucocorticoid secretion
relationship: regulates GO:0035933 ! glucocorticoid secretion
created_by: rfoulger
creation_date: 2011-07-26T08:44:43Z

[Term]
id: GO:2000850
name: negative regulation of glucocorticoid secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glucocorticoid secretion." [GOC:sl]
is_a: GO:2000847 ! negative regulation of corticosteroid hormone secretion
is_a: GO:2000849 ! regulation of glucocorticoid secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035933 ! glucocorticoid secretion
relationship: negatively_regulates GO:0035933 ! glucocorticoid secretion
created_by: rfoulger
creation_date: 2011-07-26T08:44:48Z

[Term]
id: GO:2000851
name: positive regulation of glucocorticoid secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glucocorticoid secretion." [GOC:sl]
is_a: GO:2000848 ! positive regulation of corticosteroid hormone secretion
is_a: GO:2000849 ! regulation of glucocorticoid secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035933 ! glucocorticoid secretion
relationship: positively_regulates GO:0035933 ! glucocorticoid secretion
created_by: rfoulger
creation_date: 2011-07-26T08:44:51Z

[Term]
id: GO:2000852
name: regulation of corticosterone secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of corticosterone secretion." [GOC:sl]
is_a: GO:2000849 ! regulation of glucocorticoid secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035934 ! corticosterone secretion
relationship: regulates GO:0035934 ! corticosterone secretion
created_by: rfoulger
creation_date: 2011-07-26T08:45:40Z

[Term]
id: GO:2000853
name: negative regulation of corticosterone secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of corticosterone secretion." [GOC:sl]
is_a: GO:2000850 ! negative regulation of glucocorticoid secretion
is_a: GO:2000852 ! regulation of corticosterone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035934 ! corticosterone secretion
relationship: negatively_regulates GO:0035934 ! corticosterone secretion
created_by: rfoulger
creation_date: 2011-07-26T08:45:43Z

[Term]
id: GO:2000854
name: positive regulation of corticosterone secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of corticosterone secretion." [GOC:sl]
is_a: GO:2000851 ! positive regulation of glucocorticoid secretion
is_a: GO:2000852 ! regulation of corticosterone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035934 ! corticosterone secretion
relationship: positively_regulates GO:0035934 ! corticosterone secretion
created_by: rfoulger
creation_date: 2011-07-26T08:45:45Z

[Term]
id: GO:2000855
name: regulation of mineralocorticoid secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mineralocorticoid secretion." [GOC:sl]
is_a: GO:2000846 ! regulation of corticosteroid hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035931 ! mineralocorticoid secretion
relationship: regulates GO:0035931 ! mineralocorticoid secretion
created_by: rfoulger
creation_date: 2011-07-26T08:46:38Z

[Term]
id: GO:2000856
name: negative regulation of mineralocorticoid secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mineralocorticoid secretion." [GOC:sl]
is_a: GO:2000847 ! negative regulation of corticosteroid hormone secretion
is_a: GO:2000855 ! regulation of mineralocorticoid secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035931 ! mineralocorticoid secretion
relationship: negatively_regulates GO:0035931 ! mineralocorticoid secretion
created_by: rfoulger
creation_date: 2011-07-26T08:46:42Z

[Term]
id: GO:2000857
name: positive regulation of mineralocorticoid secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mineralocorticoid secretion." [GOC:sl]
is_a: GO:2000848 ! positive regulation of corticosteroid hormone secretion
is_a: GO:2000855 ! regulation of mineralocorticoid secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035931 ! mineralocorticoid secretion
relationship: positively_regulates GO:0035931 ! mineralocorticoid secretion
created_by: rfoulger
creation_date: 2011-07-26T08:46:45Z

[Term]
id: GO:2000858
name: regulation of aldosterone secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of aldosterone secretion." [GOC:sl]
is_a: GO:2000855 ! regulation of mineralocorticoid secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035932 ! aldosterone secretion
relationship: regulates GO:0035932 ! aldosterone secretion
created_by: rfoulger
creation_date: 2011-07-26T08:47:27Z

[Term]
id: GO:2000859
name: negative regulation of aldosterone secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of aldosterone secretion." [GOC:sl]
is_a: GO:2000856 ! negative regulation of mineralocorticoid secretion
is_a: GO:2000858 ! regulation of aldosterone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035932 ! aldosterone secretion
relationship: negatively_regulates GO:0035932 ! aldosterone secretion
created_by: rfoulger
creation_date: 2011-07-26T08:47:31Z

[Term]
id: GO:2000860
name: positive regulation of aldosterone secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of aldosterone secretion." [GOC:sl]
is_a: GO:2000857 ! positive regulation of mineralocorticoid secretion
is_a: GO:2000858 ! regulation of aldosterone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035932 ! aldosterone secretion
relationship: positively_regulates GO:0035932 ! aldosterone secretion
created_by: rfoulger
creation_date: 2011-07-26T08:47:34Z

[Term]
id: GO:2000861
name: regulation of estrogen secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of estrogen secretion." [GOC:sl]
synonym: "regulation of oestrogen secretion" RELATED [GOC:obol]
is_a: GO:2000831 ! regulation of steroid hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035937 ! estrogen secretion
relationship: regulates GO:0035937 ! estrogen secretion
created_by: rfoulger
creation_date: 2011-07-26T08:48:24Z

[Term]
id: GO:2000862
name: negative regulation of estrogen secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of estrogen secretion." [GOC:sl]
synonym: "negative regulation of oestrogen secretion" RELATED [GOC:obol]
is_a: GO:2000832 ! negative regulation of steroid hormone secretion
is_a: GO:2000861 ! regulation of estrogen secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035937 ! estrogen secretion
relationship: negatively_regulates GO:0035937 ! estrogen secretion
created_by: rfoulger
creation_date: 2011-07-26T08:48:28Z

[Term]
id: GO:2000863
name: positive regulation of estrogen secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of estrogen secretion." [GOC:sl]
synonym: "positive regulation of oestrogen secretion" RELATED [GOC:obol]
is_a: GO:2000833 ! positive regulation of steroid hormone secretion
is_a: GO:2000861 ! regulation of estrogen secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035937 ! estrogen secretion
relationship: positively_regulates GO:0035937 ! estrogen secretion
created_by: rfoulger
creation_date: 2011-07-26T08:48:31Z

[Term]
id: GO:2000864
name: regulation of estradiol secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of estradiol secretion." [GOC:sl]
synonym: "regulation of oestradiol secretion" EXACT [GOC:obol]
is_a: GO:2000861 ! regulation of estrogen secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035938 ! estradiol secretion
relationship: regulates GO:0035938 ! estradiol secretion
created_by: rfoulger
creation_date: 2011-07-26T08:49:13Z

[Term]
id: GO:2000865
name: negative regulation of estradiol secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of estradiol secretion." [GOC:sl]
synonym: "negative regulation of oestradiol secretion" EXACT [GOC:obol]
is_a: GO:2000862 ! negative regulation of estrogen secretion
is_a: GO:2000864 ! regulation of estradiol secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035938 ! estradiol secretion
relationship: negatively_regulates GO:0035938 ! estradiol secretion
created_by: rfoulger
creation_date: 2011-07-26T08:49:17Z

[Term]
id: GO:2000866
name: positive regulation of estradiol secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of estradiol secretion." [GOC:sl]
synonym: "positive regulation of oestradiol secretion" EXACT [GOC:obol]
is_a: GO:2000863 ! positive regulation of estrogen secretion
is_a: GO:2000864 ! regulation of estradiol secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035938 ! estradiol secretion
relationship: positively_regulates GO:0035938 ! estradiol secretion
created_by: rfoulger
creation_date: 2011-07-26T08:49:20Z

[Term]
id: GO:2000867
name: regulation of estrone secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of estrone secretion." [GOC:sl]
synonym: "regulation of 3-hydroxy-1,3,5(10)-estratrien-17-one secretion" EXACT [GOC:obol]
synonym: "regulation of folliculin secretion" EXACT [GOC:obol]
is_a: GO:2000861 ! regulation of estrogen secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035943 ! estrone secretion
relationship: regulates GO:0035943 ! estrone secretion
created_by: rfoulger
creation_date: 2011-07-26T08:50:11Z

[Term]
id: GO:2000868
name: negative regulation of estrone secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of estrone secretion." [GOC:sl]
synonym: "negative regulation of 3-hydroxy-1,3,5(10)-estratrien-17-one secretion" EXACT [GOC:obol]
synonym: "negative regulation of folliculin secretion" EXACT [GOC:obol]
is_a: GO:2000862 ! negative regulation of estrogen secretion
is_a: GO:2000867 ! regulation of estrone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035943 ! estrone secretion
relationship: negatively_regulates GO:0035943 ! estrone secretion
created_by: rfoulger
creation_date: 2011-07-26T08:50:16Z

[Term]
id: GO:2000869
name: positive regulation of estrone secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of estrone secretion." [GOC:sl]
synonym: "positive regulation of 3-hydroxy-1,3,5(10)-estratrien-17-one secretion" EXACT [GOC:obol]
synonym: "positive regulation of folliculin secretion" EXACT [GOC:obol]
is_a: GO:2000863 ! positive regulation of estrogen secretion
is_a: GO:2000867 ! regulation of estrone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035943 ! estrone secretion
relationship: positively_regulates GO:0035943 ! estrone secretion
created_by: rfoulger
creation_date: 2011-07-26T08:50:19Z

[Term]
id: GO:2000870
name: regulation of progesterone secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of progesterone secretion." [GOC:sl]
is_a: GO:2000194 ! regulation of female gonad development
is_a: GO:2000831 ! regulation of steroid hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042701 ! progesterone secretion
relationship: regulates GO:0042701 ! progesterone secretion
created_by: rfoulger
creation_date: 2011-07-26T08:51:14Z

[Term]
id: GO:2000871
name: negative regulation of progesterone secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of progesterone secretion." [GOC:sl]
is_a: GO:2000195 ! negative regulation of female gonad development
is_a: GO:2000832 ! negative regulation of steroid hormone secretion
is_a: GO:2000870 ! regulation of progesterone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042701 ! progesterone secretion
relationship: negatively_regulates GO:0042701 ! progesterone secretion
created_by: rfoulger
creation_date: 2011-07-26T08:51:19Z

[Term]
id: GO:2000872
name: positive regulation of progesterone secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of progesterone secretion." [GOC:sl]
is_a: GO:2000196 ! positive regulation of female gonad development
is_a: GO:2000833 ! positive regulation of steroid hormone secretion
is_a: GO:2000870 ! regulation of progesterone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042701 ! progesterone secretion
relationship: positively_regulates GO:0042701 ! progesterone secretion
created_by: rfoulger
creation_date: 2011-07-26T08:51:22Z

[Term]
id: GO:2000873
name: regulation of histone H4 acetylation involved in response to DNA damage stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of histone H4 acetylation involved in response to DNA damage stimulus." [GOC:mah]
synonym: "regulation of histone H4 acetylation involved in cellular DNA damage response" EXACT [GOC:obol]
synonym: "regulation of histone H4 acetylation involved in cellular response to DNA damage stimulus" EXACT [GOC:obol]
synonym: "regulation of histone H4 acetylation involved in DNA damage response" EXACT [GOC:obol]
synonym: "regulation of histone H4 acetylation involved in response to DNA damage" EXACT [GOC:bf]
synonym: "regulation of histone H4 acetylation involved in response to genotoxic stress" EXACT [GOC:obol]
is_a: GO:0090239 ! regulation of histone H4 acetylation
is_a: GO:2001020 ! regulation of response to DNA damage stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:2000776 ! histone H4 acetylation involved in response to DNA damage stimulus
relationship: regulates GO:2000776 ! histone H4 acetylation involved in response to DNA damage stimulus
created_by: midori
creation_date: 2011-07-26T10:05:23Z

[Term]
id: GO:2000874
name: regulation of glyoxylate cycle
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glyoxylate cycle." [GOC:dgf]
synonym: "regulation of glyoxylate bypass" EXACT [GOC:obol]
is_a: GO:0010565 ! regulation of cellular ketone metabolic process
is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006097 ! glyoxylate cycle
relationship: regulates GO:0006097 ! glyoxylate cycle
created_by: rfoulger
creation_date: 2011-07-27T01:27:10Z

[Term]
id: GO:2000875
name: negative regulation of glyoxylate cycle
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glyoxylate cycle." [GOC:dgf]
synonym: "negative regulation of glyoxylate bypass" EXACT [GOC:obol]
is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process
is_a: GO:2000874 ! regulation of glyoxylate cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006097 ! glyoxylate cycle
relationship: negatively_regulates GO:0006097 ! glyoxylate cycle
created_by: rfoulger
creation_date: 2011-07-27T01:27:15Z

[Term]
id: GO:2000876
name: positive regulation of glyoxylate cycle
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glyoxylate cycle." [GOC:dgf]
synonym: "positive regulation of glyoxylate bypass" EXACT [GOC:obol]
is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process
is_a: GO:2000874 ! regulation of glyoxylate cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006097 ! glyoxylate cycle
relationship: positively_regulates GO:0006097 ! glyoxylate cycle
created_by: rfoulger
creation_date: 2011-07-27T01:27:18Z

[Term]
id: GO:2000877
name: negative regulation of oligopeptide transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of oligopeptide transport." [GOC:obol]
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:0090088 ! regulation of oligopeptide transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006857 ! oligopeptide transport
relationship: negatively_regulates GO:0006857 ! oligopeptide transport
created_by: rfoulger
creation_date: 2011-07-27T01:54:07Z

[Term]
id: GO:2000878
name: positive regulation of oligopeptide transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of oligopeptide transport." [GOC:obol]
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:0090088 ! regulation of oligopeptide transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006857 ! oligopeptide transport
relationship: positively_regulates GO:0006857 ! oligopeptide transport
created_by: rfoulger
creation_date: 2011-07-27T01:54:11Z

[Term]
id: GO:2000879
name: negative regulation of dipeptide transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of dipeptide transport." [GOC:obol]
is_a: GO:0090089 ! regulation of dipeptide transport
is_a: GO:2000877 ! negative regulation of oligopeptide transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042938 ! dipeptide transport
relationship: negatively_regulates GO:0042938 ! dipeptide transport
created_by: rfoulger
creation_date: 2011-07-27T02:55:21Z

[Term]
id: GO:2000880
name: positive regulation of dipeptide transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of dipeptide transport." [GOC:obol]
is_a: GO:0090089 ! regulation of dipeptide transport
is_a: GO:2000878 ! positive regulation of oligopeptide transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042938 ! dipeptide transport
relationship: positively_regulates GO:0042938 ! dipeptide transport
created_by: rfoulger
creation_date: 2011-07-27T02:55:24Z

[Term]
id: GO:2000881
name: regulation of starch catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of starch catabolic process." [GOC:obol]
synonym: "regulation of starch breakdown" EXACT [GOC:obol]
synonym: "regulation of starch catabolism" EXACT [GOC:obol]
synonym: "regulation of starch degradation" EXACT [GOC:obol]
is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process
is_a: GO:2000904 ! regulation of starch metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0005983 ! starch catabolic process
relationship: regulates GO:0005983 ! starch catabolic process
created_by: rfoulger
creation_date: 2011-07-27T03:23:39Z

[Term]
id: GO:2000882
name: negative regulation of starch catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of starch catabolic process." [GOC:obol]
synonym: "negative regulation of starch breakdown" EXACT [GOC:obol]
synonym: "negative regulation of starch catabolism" EXACT [GOC:obol]
synonym: "negative regulation of starch degradation" EXACT [GOC:obol]
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:2000881 ! regulation of starch catabolic process
is_a: GO:2000905 ! negative regulation of starch metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0005983 ! starch catabolic process
relationship: negatively_regulates GO:0005983 ! starch catabolic process
created_by: rfoulger
creation_date: 2011-07-27T03:23:46Z

[Term]
id: GO:2000883
name: positive regulation of starch catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of starch catabolic process." [GOC:obol]
synonym: "positive regulation of starch breakdown" EXACT [GOC:obol]
synonym: "positive regulation of starch catabolism" EXACT [GOC:obol]
synonym: "positive regulation of starch degradation" EXACT [GOC:obol]
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:2000881 ! regulation of starch catabolic process
is_a: GO:2000906 ! positive regulation of starch metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0005983 ! starch catabolic process
relationship: positively_regulates GO:0005983 ! starch catabolic process
created_by: rfoulger
creation_date: 2011-07-27T03:23:51Z

[Term]
id: GO:2000884
name: glucomannan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a glucomannan." [GOC:mengo_curators]
synonym: "glucomannan catabolism" EXACT [GOC:obol]
is_a: GO:0000272 ! polysaccharide catabolic process
is_a: GO:0010391 ! glucomannan metabolic process
created_by: jane
creation_date: 2011-07-28T09:19:03Z

[Term]
id: GO:2000885
name: galactoglucomannan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a galactoglucomannan." [GOC:mengo_curators]
synonym: "galactoglucomannan catabolism" EXACT [GOC:obol]
is_a: GO:0000272 ! polysaccharide catabolic process
is_a: GO:0010392 ! galactoglucomannan metabolic process
created_by: jane
creation_date: 2011-07-28T09:24:11Z

[Term]
id: GO:2000886
name: glucuronoxylan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a glucuronoxylan." [GOC:mengo_curators]
synonym: "glucuronoxylan catabolism" EXACT [GOC:obol]
is_a: GO:0010413 ! glucuronoxylan metabolic process
is_a: GO:0045493 ! xylan catabolic process
created_by: jane
creation_date: 2011-07-28T09:37:06Z

[Term]
id: GO:2000887
name: glucuronoarabinoxylan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a glucuronoarabinoxylan." [GOC:mengo_curators]
synonym: "glucuronoarabinoxylan catabolism" EXACT [GOC:obol]
is_a: GO:0010414 ! glucuronoarabinoxylan metabolic process
is_a: GO:2000886 ! glucuronoxylan catabolic process
is_a: GO:2000888 ! arabinoxylan-containing compound catabolic process
created_by: jane
creation_date: 2011-07-28T09:39:26Z

[Term]
id: GO:2000888
name: arabinoxylan-containing compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of an arabinoxylan." [GOC:mengo_curators]
synonym: "arabinoxylan catabolic process" RELATED []
synonym: "arabinoxylan catabolism" RELATED [GOC:obol]
is_a: GO:0010416 ! arabinoxylan-containing compound metabolic process
is_a: GO:0045493 ! xylan catabolic process
created_by: jane
creation_date: 2011-07-28T09:31:50Z

[Term]
id: GO:2000889
name: cellodextrin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a cellodextrin." [GOC:obol]
synonym: "cellodextrin metabolism" EXACT [GOC:obol]
is_a: GO:0009311 ! oligosaccharide metabolic process
is_a: GO:0044042 ! glucan metabolic process
created_by: jane
creation_date: 2011-07-28T01:00:04Z

[Term]
id: GO:2000890
name: cellodextrin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a cellodextrin." [GOC:mengo_curators]
synonym: "cellodextrin catabolism" EXACT [GOC:obol]
is_a: GO:0009251 ! glucan catabolic process
is_a: GO:0009313 ! oligosaccharide catabolic process
is_a: GO:2000889 ! cellodextrin metabolic process
created_by: jane
creation_date: 2011-07-28T01:05:21Z

[Term]
id: GO:2000891
name: cellobiose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a cellobiose." [GOC:mengo_curators]
synonym: "cellobiose metabolism" EXACT [GOC:obol]
is_a: GO:0005984 ! disaccharide metabolic process
created_by: jane
creation_date: 2011-07-28T01:35:35Z

[Term]
id: GO:2000892
name: cellobiose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a cellobiose." [GOC:mengo_curators]
synonym: "cellobiose catabolism" EXACT [GOC:obol]
is_a: GO:0046352 ! disaccharide catabolic process
is_a: GO:2000891 ! cellobiose metabolic process
created_by: jane
creation_date: 2011-07-28T01:35:38Z

[Term]
id: GO:2000893
name: cellotriose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a cellotriose." [GOC:mengo_curators]
synonym: "cellotriose metabolism" EXACT [GOC:obol]
is_a: GO:0009311 ! oligosaccharide metabolic process
created_by: jane
creation_date: 2011-07-28T02:02:44Z

[Term]
id: GO:2000894
name: cellotriose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a cellotriose." [GOC:mengo_curators]
synonym: "cellotriose catabolism" EXACT [GOC:obol]
is_a: GO:0009313 ! oligosaccharide catabolic process
is_a: GO:2000893 ! cellotriose metabolic process
created_by: jane
creation_date: 2011-07-28T02:02:47Z

[Term]
id: GO:2000895
name: hemicellulose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a hemicellulose." [GOC:mengo_curators]
synonym: "hemicellulose catabolism" EXACT [GOC:obol]
is_a: GO:0000272 ! polysaccharide catabolic process
is_a: GO:0010410 ! hemicellulose metabolic process
created_by: jane
creation_date: 2011-07-28T02:08:11Z

[Term]
id: GO:2000896
name: amylopectin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an amylopectin." [GOC:mengo_curators]
synonym: "Amylopectin metabolism" EXACT [GOC:obol]
is_a: GO:0043170 ! macromolecule metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process
created_by: jane
creation_date: 2011-07-28T02:47:25Z

[Term]
id: GO:2000897
name: amylopectin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of an amylopectin." [GOC:mengo_curators]
synonym: "Amylopectin catabolism" EXACT [GOC:obol]
is_a: GO:0009057 ! macromolecule catabolic process
is_a: GO:1901136 ! carbohydrate derivative catabolic process
is_a: GO:2000896 ! amylopectin metabolic process
created_by: jane
creation_date: 2011-07-28T02:47:28Z

[Term]
id: GO:2000898
name: regulation of glucomannan catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glucomannan catabolic process." [GOC:mengo_curators]
synonym: "regulation of glucomannan catabolism" EXACT [GOC:obol]
is_a: GO:0032881 ! regulation of polysaccharide metabolic process
is_a: GO:0043470 ! regulation of carbohydrate catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:2000884 ! glucomannan catabolic process
relationship: regulates GO:2000884 ! glucomannan catabolic process
created_by: trudy
creation_date: 2011-07-29T01:13:16Z

[Term]
id: GO:2000899
name: xyloglucan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a xyloglucan." [GOC:mengo_curators]
synonym: "xyloglucan catabolism" EXACT [GOC:obol]
is_a: GO:0009251 ! glucan catabolic process
is_a: GO:0010411 ! xyloglucan metabolic process
is_a: GO:2000895 ! hemicellulose catabolic process
created_by: jane
creation_date: 2011-07-28T02:52:33Z

[Term]
id: GO:2000900
name: cyclodextrin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a cyclodextrin." [GOC:mengo_curators]
synonym: "cyclodextrin metabolism" EXACT [GOC:obol]
is_a: GO:0009311 ! oligosaccharide metabolic process
created_by: jane
creation_date: 2011-07-28T03:19:11Z

[Term]
id: GO:2000901
name: cyclodextrin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a cyclodextrin." [GOC:mengo_curators]
synonym: "cyclodextrin catabolism" EXACT [GOC:obol]
is_a: GO:0009313 ! oligosaccharide catabolic process
is_a: GO:2000900 ! cyclodextrin metabolic process
created_by: jane
creation_date: 2011-07-28T03:19:13Z

[Term]
id: GO:2000902
name: cellooligosaccharide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a cellooligosaccharide." [GOC:mengo_curators]
synonym: "cellooligosaccharide metabolism" EXACT [GOC:obol]
is_a: GO:0009311 ! oligosaccharide metabolic process
created_by: jane
creation_date: 2011-07-28T03:21:46Z

[Term]
id: GO:2000903
name: cellooligosaccharide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a cellooligosaccharide." [GOC:mengo_curators]
synonym: "cellooligosaccharide catabolism" EXACT [GOC:obol]
is_a: GO:0009313 ! oligosaccharide catabolic process
is_a: GO:2000902 ! cellooligosaccharide metabolic process
created_by: jane
creation_date: 2011-07-28T03:21:49Z

[Term]
id: GO:2000904
name: regulation of starch metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of starch metabolic process." [GOC:obol]
synonym: "regulation of starch metabolism" EXACT [GOC:obol]
is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process
is_a: GO:0032881 ! regulation of polysaccharide metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0005982 ! starch metabolic process
relationship: regulates GO:0005982 ! starch metabolic process
created_by: tanyaberardini
creation_date: 2011-07-28T11:33:13Z

[Term]
id: GO:2000905
name: negative regulation of starch metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of starch metabolic process." [GOC:obol]
synonym: "negative regulation of starch metabolism" EXACT [GOC:obol]
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process
is_a: GO:2000904 ! regulation of starch metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0005982 ! starch metabolic process
relationship: negatively_regulates GO:0005982 ! starch metabolic process
created_by: tanyaberardini
creation_date: 2011-07-28T11:33:17Z

[Term]
id: GO:2000906
name: positive regulation of starch metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of starch metabolic process." [GOC:obol]
synonym: "positive regulation of starch metabolism" EXACT [GOC:obol]
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process
is_a: GO:2000904 ! regulation of starch metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0005982 ! starch metabolic process
relationship: positively_regulates GO:0005982 ! starch metabolic process
created_by: tanyaberardini
creation_date: 2011-07-28T11:33:19Z

[Term]
id: GO:2000907
name: negative regulation of glucomannan catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glucomannan catabolic process." [GOC:mengo_curators]
synonym: "negative regulation of glucomannan catabolism" EXACT [GOC:obol]
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:2000898 ! regulation of glucomannan catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:2000884 ! glucomannan catabolic process
relationship: negatively_regulates GO:2000884 ! glucomannan catabolic process
created_by: trudy
creation_date: 2011-07-29T01:13:24Z

[Term]
id: GO:2000908
name: positive regulation of glucomannan catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glucomannan catabolic process." [GOC:mengo_curators]
synonym: "positive regulation of glucomannan catabolism" EXACT [GOC:obol]
is_a: GO:2000898 ! regulation of glucomannan catabolic process
is_a: GO:2000996 ! positive regulation of mannan catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:2000884 ! glucomannan catabolic process
relationship: positively_regulates GO:2000884 ! glucomannan catabolic process
created_by: trudy
creation_date: 2011-07-29T01:13:30Z

[Term]
id: GO:2000909
name: regulation of sterol import
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sterol import." [GOC:obol]
synonym: "regulation of sterol influx" EXACT [GOC:obol]
synonym: "regulation of sterol uptake" EXACT [GOC:obol]
is_a: GO:0032371 ! regulation of sterol transport
is_a: GO:0034762 ! regulation of transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035376 ! sterol import
relationship: regulates GO:0035376 ! sterol import
created_by: rfoulger
creation_date: 2011-07-29T01:25:10Z

[Term]
id: GO:2000910
name: negative regulation of sterol import
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sterol import." [GOC:obol]
synonym: "negative regulation of sterol influx" EXACT [GOC:obol]
synonym: "negative regulation of sterol uptake" EXACT [GOC:obol]
is_a: GO:0032372 ! negative regulation of sterol transport
is_a: GO:0034763 ! negative regulation of transmembrane transport
is_a: GO:2000909 ! regulation of sterol import
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035376 ! sterol import
relationship: negatively_regulates GO:0035376 ! sterol import
created_by: rfoulger
creation_date: 2011-07-29T01:25:14Z

[Term]
id: GO:2000911
name: positive regulation of sterol import
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sterol import." [GOC:obol]
synonym: "positive regulation of sterol influx" EXACT [GOC:obol]
synonym: "positive regulation of sterol uptake" EXACT [GOC:obol]
is_a: GO:0032373 ! positive regulation of sterol transport
is_a: GO:0034764 ! positive regulation of transmembrane transport
is_a: GO:2000909 ! regulation of sterol import
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035376 ! sterol import
relationship: positively_regulates GO:0035376 ! sterol import
created_by: rfoulger
creation_date: 2011-07-29T01:25:17Z

[Term]
id: GO:2000912
name: regulation of galactoglucomannan catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of galactoglucomannan catabolic process." [GOC:mengo_curators]
synonym: "regulation of galactoglucomannan catabolism" EXACT [GOC:obol]
is_a: GO:0032881 ! regulation of polysaccharide metabolic process
is_a: GO:0043470 ! regulation of carbohydrate catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:2000885 ! galactoglucomannan catabolic process
relationship: regulates GO:2000885 ! galactoglucomannan catabolic process
created_by: trudy
creation_date: 2011-07-29T07:51:31Z

[Term]
id: GO:2000913
name: negative regulation of galactoglucomannan catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of galactoglucomannan catabolic process." [GOC:mengo_curators]
synonym: "negative regulation of galactoglucomannan catabolism" EXACT [GOC:obol]
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:2000912 ! regulation of galactoglucomannan catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:2000885 ! galactoglucomannan catabolic process
relationship: negatively_regulates GO:2000885 ! galactoglucomannan catabolic process
created_by: trudy
creation_date: 2011-07-29T07:51:41Z

[Term]
id: GO:2000914
name: positive regulation of galactoglucomannan catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of galactoglucomannan catabolic process." [GOC:mengo_curators]
synonym: "positive regulation of galactoglucomannan catabolism" EXACT [GOC:obol]
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process
is_a: GO:2000912 ! regulation of galactoglucomannan catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:2000885 ! galactoglucomannan catabolic process
relationship: positively_regulates GO:2000885 ! galactoglucomannan catabolic process
created_by: trudy
creation_date: 2011-07-29T07:51:50Z

[Term]
id: GO:2000915
name: regulation of glucuronoxylan catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glucuronoxylan catabolic process." [GOC:mengo_curators]
synonym: "regulation of glucuronoxylan catabolism" EXACT [GOC:obol]
is_a: GO:2001000 ! regulation of xylan catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:2000886 ! glucuronoxylan catabolic process
relationship: regulates GO:2000886 ! glucuronoxylan catabolic process
created_by: trudy
creation_date: 2011-07-29T07:54:35Z

[Term]
id: GO:2000916
name: negative regulation of glucuronoxylan catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glucuronoxylan catabolic process." [GOC:mengo_curators]
synonym: "negative regulation of glucuronoxylan catabolism" EXACT [GOC:obol]
is_a: GO:2000915 ! regulation of glucuronoxylan catabolic process
is_a: GO:2001001 ! negative regulation of xylan catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:2000886 ! glucuronoxylan catabolic process
relationship: negatively_regulates GO:2000886 ! glucuronoxylan catabolic process
created_by: trudy
creation_date: 2011-07-29T07:54:44Z

[Term]
id: GO:2000917
name: positive regulation of glucuronoxylan catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glucuronoxylan catabolic process." [GOC:mengo_curators]
synonym: "positive regulation of glucuronoxylan catabolism" EXACT [GOC:obol]
is_a: GO:2000915 ! regulation of glucuronoxylan catabolic process
is_a: GO:2001002 ! positive regulation of xylan catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:2000886 ! glucuronoxylan catabolic process
relationship: positively_regulates GO:2000886 ! glucuronoxylan catabolic process
created_by: trudy
creation_date: 2011-07-29T07:54:50Z

[Term]
id: GO:2000918
name: regulation of glucuronoarabinoxylan catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glucuronoarabinoxylan catabolic process." [GOC:mengo_curators]
synonym: "regulation of glucuronoarabinoxylan catabolism" EXACT [GOC:obol]
is_a: GO:2000915 ! regulation of glucuronoxylan catabolic process
is_a: GO:2000921 ! regulation of arabinoxylan-containing compound catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:2000887 ! glucuronoarabinoxylan catabolic process
relationship: regulates GO:2000887 ! glucuronoarabinoxylan catabolic process
created_by: trudy
creation_date: 2011-08-01T12:36:47Z

[Term]
id: GO:2000919
name: negative regulation of glucuronoarabinoxylan catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glucuronoarabinoxylan catabolic process." [GOC:mengo_curators]
synonym: "negative regulation of glucuronoarabinoxylan catabolism" EXACT [GOC:obol]
is_a: GO:2000916 ! negative regulation of glucuronoxylan catabolic process
is_a: GO:2000918 ! regulation of glucuronoarabinoxylan catabolic process
is_a: GO:2000922 ! negative regulation of arabinoxylan-containing compound catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:2000887 ! glucuronoarabinoxylan catabolic process
relationship: negatively_regulates GO:2000887 ! glucuronoarabinoxylan catabolic process
created_by: trudy
creation_date: 2011-08-01T12:36:53Z

[Term]
id: GO:2000920
name: positive regulation of glucuronoarabinoxylan catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glucuronoarabinoxylan catabolic process." [GOC:mengo_curators]
synonym: "positive regulation of glucuronoarabinoxylan catabolism" EXACT [GOC:obol]
is_a: GO:2000917 ! positive regulation of glucuronoxylan catabolic process
is_a: GO:2000918 ! regulation of glucuronoarabinoxylan catabolic process
is_a: GO:2000923 ! positive regulation of arabinoxylan-containing compound catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:2000887 ! glucuronoarabinoxylan catabolic process
relationship: positively_regulates GO:2000887 ! glucuronoarabinoxylan catabolic process
created_by: trudy
creation_date: 2011-08-01T12:36:58Z

[Term]
id: GO:2000921
name: regulation of arabinoxylan-containing compound catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of arabinoxylan-containing compound catabolic process." [GOC:mengo_curators]
synonym: "regulation of arabinoxylan catabolism" EXACT [GOC:obol]
is_a: GO:2001000 ! regulation of xylan catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:2000888 ! arabinoxylan-containing compound catabolic process
relationship: regulates GO:2000888 ! arabinoxylan-containing compound catabolic process
created_by: trudy
creation_date: 2011-08-01T12:38:56Z

[Term]
id: GO:2000922
name: negative regulation of arabinoxylan-containing compound catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of arabinoxylan-containing compound catabolic process." [GOC:mengo_curators]
synonym: "negative regulation of arabinoxylan catabolism" EXACT [GOC:obol]
is_a: GO:2000921 ! regulation of arabinoxylan-containing compound catabolic process
is_a: GO:2001001 ! negative regulation of xylan catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:2000888 ! arabinoxylan-containing compound catabolic process
relationship: negatively_regulates GO:2000888 ! arabinoxylan-containing compound catabolic process
created_by: trudy
creation_date: 2011-08-01T12:39:00Z

[Term]
id: GO:2000923
name: positive regulation of arabinoxylan-containing compound catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of arabinoxylan-containing compound catabolic process." [GOC:mengo_curators]
synonym: "positive regulation of arabinoxylan catabolism" EXACT [GOC:obol]
is_a: GO:2000921 ! regulation of arabinoxylan-containing compound catabolic process
is_a: GO:2001002 ! positive regulation of xylan catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:2000888 ! arabinoxylan-containing compound catabolic process
relationship: positively_regulates GO:2000888 ! arabinoxylan-containing compound catabolic process
created_by: trudy
creation_date: 2011-08-01T12:39:02Z

[Term]
id: GO:2000924
name: regulation of cellodextrin metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellodextrin metabolic process." [GOC:mengo_curators]
synonym: "regulation of cellodextrin metabolism" EXACT [GOC:obol]
is_a: GO:0032881 ! regulation of polysaccharide metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:2000889 ! cellodextrin metabolic process
relationship: regulates GO:2000889 ! cellodextrin metabolic process
created_by: trudy
creation_date: 2011-08-01T12:39:52Z

[Term]
id: GO:2000925
name: negative regulation of cellodextrin metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellodextrin metabolic process." [GOC:mengo_curators]
synonym: "negative regulation of cellodextrin metabolism" EXACT [GOC:obol]
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:2000924 ! regulation of cellodextrin metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:2000889 ! cellodextrin metabolic process
relationship: negatively_regulates GO:2000889 ! cellodextrin metabolic process
created_by: trudy
creation_date: 2011-08-01T12:39:56Z

[Term]
id: GO:2000926
name: positive regulation of cellodextrin metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellodextrin metabolic process." [GOC:mengo_curators]
synonym: "positive regulation of cellodextrin metabolism" EXACT [GOC:obol]
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process
is_a: GO:2000924 ! regulation of cellodextrin metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:2000889 ! cellodextrin metabolic process
relationship: positively_regulates GO:2000889 ! cellodextrin metabolic process
created_by: trudy
creation_date: 2011-08-01T12:39:59Z

[Term]
id: GO:2000927
name: regulation of cellodextrin catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellodextrin catabolic process." [GOC:mengo_curators]
synonym: "regulation of cellodextrin catabolism" EXACT [GOC:obol]
is_a: GO:0043470 ! regulation of carbohydrate catabolic process
is_a: GO:2000924 ! regulation of cellodextrin metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:2000890 ! cellodextrin catabolic process
relationship: regulates GO:2000890 ! cellodextrin catabolic process
created_by: trudy
creation_date: 2011-08-01T12:41:29Z

[Term]
id: GO:2000928
name: negative regulation of cellodextrin catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellodextrin catabolic process." [GOC:mengo_curators]
synonym: "negative regulation of cellodextrin catabolism" EXACT [GOC:obol]
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:2000925 ! negative regulation of cellodextrin metabolic process
is_a: GO:2000927 ! regulation of cellodextrin catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:2000890 ! cellodextrin catabolic process
relationship: negatively_regulates GO:2000890 ! cellodextrin catabolic process
created_by: trudy
creation_date: 2011-08-01T12:41:33Z

[Term]
id: GO:2000929
name: positive regulation of cellodextrin catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellodextrin catabolic process." [GOC:mengo_curators]
synonym: "positive regulation of cellodextrin catabolism" EXACT [GOC:obol]
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:2000926 ! positive regulation of cellodextrin metabolic process
is_a: GO:2000927 ! regulation of cellodextrin catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:2000890 ! cellodextrin catabolic process
relationship: positively_regulates GO:2000890 ! cellodextrin catabolic process
created_by: trudy
creation_date: 2011-08-01T12:41:36Z

[Term]
id: GO:2000930
name: regulation of cellobiose metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellobiose metabolic process." [GOC:mengo_curators]
synonym: "regulation of cellobiose metabolism" EXACT [GOC:obol]
is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:2000891 ! cellobiose metabolic process
relationship: regulates GO:2000891 ! cellobiose metabolic process
created_by: trudy
creation_date: 2011-08-01T12:42:53Z

[Term]
id: GO:2000931
name: negative regulation of cellobiose metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellobiose metabolic process." [GOC:mengo_curators]
synonym: "negative regulation of cellobiose metabolism" EXACT [GOC:obol]
is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process
is_a: GO:2000930 ! regulation of cellobiose metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:2000891 ! cellobiose metabolic process
relationship: negatively_regulates GO:2000891 ! cellobiose metabolic process
created_by: trudy
creation_date: 2011-08-01T12:42:57Z

[Term]
id: GO:2000932
name: positive regulation of cellobiose metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellobiose metabolic process." [GOC:mengo_curators]
synonym: "positive regulation of cellobiose metabolism" EXACT [GOC:obol]
is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process
is_a: GO:2000930 ! regulation of cellobiose metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:2000891 ! cellobiose metabolic process
relationship: positively_regulates GO:2000891 ! cellobiose metabolic process
created_by: trudy
creation_date: 2011-08-01T12:43:01Z

[Term]
id: GO:2000933
name: regulation of cellotriose metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellotriose metabolic process." [GOC:mengo_curators]
synonym: "regulation of cellotriose metabolism" EXACT [GOC:obol]
is_a: GO:0032881 ! regulation of polysaccharide metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:2000893 ! cellotriose metabolic process
relationship: regulates GO:2000893 ! cellotriose metabolic process
created_by: trudy
creation_date: 2011-08-01T12:44:15Z

[Term]
id: GO:2000934
name: negative regulation of cellotriose metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellotriose metabolic process." [GOC:mengo_curators]
synonym: "negative regulation of cellotriose metabolism" EXACT [GOC:obol]
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:2000933 ! regulation of cellotriose metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:2000893 ! cellotriose metabolic process
relationship: negatively_regulates GO:2000893 ! cellotriose metabolic process
created_by: trudy
creation_date: 2011-08-01T12:44:20Z

[Term]
id: GO:2000935
name: positive regulation of cellotriose metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellotriose metabolic process." [GOC:mengo_curators]
synonym: "positive regulation of cellotriose metabolism" EXACT [GOC:obol]
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process
is_a: GO:2000933 ! regulation of cellotriose metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:2000893 ! cellotriose metabolic process
relationship: positively_regulates GO:2000893 ! cellotriose metabolic process
created_by: trudy
creation_date: 2011-08-01T12:44:24Z

[Term]
id: GO:2000936
name: regulation of cellotriose catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellotriose catabolic process." [GOC:mengo_curators]
synonym: "regulation of cellotriose catabolism" EXACT [GOC:obol]
is_a: GO:0043470 ! regulation of carbohydrate catabolic process
is_a: GO:2000933 ! regulation of cellotriose metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:2000894 ! cellotriose catabolic process
relationship: regulates GO:2000894 ! cellotriose catabolic process
created_by: trudy
creation_date: 2011-08-01T12:45:26Z

[Term]
id: GO:2000937
name: negative regulation of cellotriose catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellotriose catabolic process." [GOC:mengo_curators]
synonym: "negative regulation of cellotriose catabolism" EXACT [GOC:obol]
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:2000934 ! negative regulation of cellotriose metabolic process
is_a: GO:2000936 ! regulation of cellotriose catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:2000894 ! cellotriose catabolic process
relationship: negatively_regulates GO:2000894 ! cellotriose catabolic process
created_by: trudy
creation_date: 2011-08-01T12:45:31Z

[Term]
id: GO:2000938
name: positive regulation of cellotriose catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellotriose catabolic process." [GOC:mengo_curators]
synonym: "positive regulation of cellotriose catabolism" EXACT [GOC:obol]
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:2000935 ! positive regulation of cellotriose metabolic process
is_a: GO:2000936 ! regulation of cellotriose catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:2000894 ! cellotriose catabolic process
relationship: positively_regulates GO:2000894 ! cellotriose catabolic process
created_by: trudy
creation_date: 2011-08-01T12:45:35Z

[Term]
id: GO:2000939
name: regulation of plant-type cell wall cellulose catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of plant-type cell wall cellulose catabolic process." [GOC:mengo_curators]
synonym: "regulation of plant-type cell wall polysaccharide breakdown" EXACT [GOC:obol]
is_a: GO:0032950 ! regulation of beta-glucan metabolic process
is_a: GO:0051128 ! regulation of cellular component organization
is_a: GO:2000966 ! regulation of cell wall polysaccharide catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044348 ! plant-type cell wall cellulose catabolic process
relationship: regulates GO:0044348 ! plant-type cell wall cellulose catabolic process
created_by: trudy
creation_date: 2011-08-01T02:07:11Z

[Term]
id: GO:2000940
name: negative regulation of plant-type cell wall cellulose catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of plant-type cell wall cellulose catabolic process." [GOC:mengo_curators]
synonym: "negative regulation of plant-type cell wall polysaccharide breakdown" EXACT [GOC:obol]
is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:2000939 ! regulation of plant-type cell wall cellulose catabolic process
is_a: GO:2000967 ! negative regulation of cell wall polysaccharide catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044348 ! plant-type cell wall cellulose catabolic process
relationship: negatively_regulates GO:0044348 ! plant-type cell wall cellulose catabolic process
created_by: trudy
creation_date: 2011-08-01T02:07:17Z

[Term]
id: GO:2000941
name: positive regulation of plant-type cell wall cellulose catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of plant-type cell wall cellulose catabolic process." [GOC:mengo_curators]
synonym: "positive regulation of plant-type cell wall polysaccharide breakdown" EXACT [GOC:obol]
is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:2000939 ! regulation of plant-type cell wall cellulose catabolic process
is_a: GO:2000968 ! positive regulation of cell wall polysaccharide catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044348 ! plant-type cell wall cellulose catabolic process
relationship: positively_regulates GO:0044348 ! plant-type cell wall cellulose catabolic process
created_by: trudy
creation_date: 2011-08-01T02:07:21Z

[Term]
id: GO:2000942
name: regulation of amylopectin metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of amylopectin metabolic process." [GOC:mengo_curators]
synonym: "regulation of Amylopectin metabolism" EXACT [GOC:obol]
is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:0060255 ! regulation of macromolecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:2000896 ! amylopectin metabolic process
relationship: regulates GO:2000896 ! amylopectin metabolic process
created_by: trudy
creation_date: 2011-08-01T02:10:28Z

[Term]
id: GO:2000943
name: negative regulation of amylopectin metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of amylopectin metabolic process." [GOC:mengo_curators]
synonym: "negative regulation of Amylopectin metabolism" EXACT [GOC:obol]
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:2000942 ! regulation of amylopectin metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:2000896 ! amylopectin metabolic process
relationship: negatively_regulates GO:2000896 ! amylopectin metabolic process
created_by: trudy
creation_date: 2011-08-01T02:10:32Z

[Term]
id: GO:2000944
name: positive regulation of amylopectin metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of amylopectin metabolic process." [GOC:mengo_curators]
synonym: "positive regulation of Amylopectin metabolism" EXACT [GOC:obol]
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:2000942 ! regulation of amylopectin metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:2000896 ! amylopectin metabolic process
relationship: positively_regulates GO:2000896 ! amylopectin metabolic process
created_by: trudy
creation_date: 2011-08-01T02:10:36Z

[Term]
id: GO:2000945
name: regulation of amylopectin catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of amylopectin catabolic process." [GOC:mengo_curators]
synonym: "regulation of Amylopectin catabolism" EXACT [GOC:obol]
is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:2000942 ! regulation of amylopectin metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:2000897 ! amylopectin catabolic process
relationship: regulates GO:2000897 ! amylopectin catabolic process
created_by: trudy
creation_date: 2011-08-01T02:15:22Z

[Term]
id: GO:2000946
name: negative regulation of amylopectin catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of amylopectin catabolic process." [GOC:mengo_curators]
synonym: "negative regulation of Amylopectin catabolism" EXACT [GOC:obol]
is_a: GO:2000882 ! negative regulation of starch catabolic process
is_a: GO:2000943 ! negative regulation of amylopectin metabolic process
is_a: GO:2000945 ! regulation of amylopectin catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:2000897 ! amylopectin catabolic process
relationship: negatively_regulates GO:2000897 ! amylopectin catabolic process
created_by: trudy
creation_date: 2011-08-01T02:15:27Z

[Term]
id: GO:2000947
name: positive regulation of amylopectin catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of amylopectin catabolic process." [GOC:mengo_curators]
synonym: "positive regulation of Amylopectin catabolism" EXACT [GOC:obol]
is_a: GO:2000883 ! positive regulation of starch catabolic process
is_a: GO:2000944 ! positive regulation of amylopectin metabolic process
is_a: GO:2000945 ! regulation of amylopectin catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:2000897 ! amylopectin catabolic process
relationship: positively_regulates GO:2000897 ! amylopectin catabolic process
created_by: trudy
creation_date: 2011-08-01T02:15:32Z

[Term]
id: GO:2000948
name: regulation of xyloglucan metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of xyloglucan metabolic process." [GOC:mengo_curators]
synonym: "regulation of xyloglucan metabolism" EXACT [GOC:obol]
is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process
is_a: GO:0010981 ! regulation of cell wall macromolecule metabolic process
is_a: GO:0032881 ! regulation of polysaccharide metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010411 ! xyloglucan metabolic process
relationship: regulates GO:0010411 ! xyloglucan metabolic process
created_by: trudy
creation_date: 2011-08-01T02:16:54Z

[Term]
id: GO:2000949
name: negative regulation of xyloglucan metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of xyloglucan metabolic process." [GOC:mengo_curators]
synonym: "negative regulation of xyloglucan metabolism" EXACT [GOC:obol]
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process
is_a: GO:1903339 ! negative regulation of cell wall organization or biogenesis
is_a: GO:2000948 ! regulation of xyloglucan metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010411 ! xyloglucan metabolic process
relationship: negatively_regulates GO:0010411 ! xyloglucan metabolic process
created_by: trudy
creation_date: 2011-08-01T02:16:59Z

[Term]
id: GO:2000950
name: positive regulation of xyloglucan metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of xyloglucan metabolic process." [GOC:mengo_curators]
synonym: "positive regulation of xyloglucan metabolism" EXACT [GOC:obol]
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process
is_a: GO:1903340 ! positive regulation of cell wall organization or biogenesis
is_a: GO:2000948 ! regulation of xyloglucan metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010411 ! xyloglucan metabolic process
relationship: positively_regulates GO:0010411 ! xyloglucan metabolic process
created_by: trudy
creation_date: 2011-08-01T02:17:02Z

[Term]
id: GO:2000951
name: regulation of xyloglucan catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of xyloglucan catabolic process." [GOC:mengo_curators]
synonym: "regulation of xyloglucan catabolism" EXACT [GOC:obol]
is_a: GO:2000948 ! regulation of xyloglucan metabolic process
is_a: GO:2000988 ! regulation of hemicellulose catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:2000899 ! xyloglucan catabolic process
relationship: regulates GO:2000899 ! xyloglucan catabolic process
created_by: trudy
creation_date: 2011-08-01T02:20:16Z

[Term]
id: GO:2000952
name: negative regulation of xyloglucan catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of xyloglucan catabolic process." [GOC:mengo_curators]
synonym: "negative regulation of xyloglucan catabolism" EXACT [GOC:obol]
is_a: GO:2000949 ! negative regulation of xyloglucan metabolic process
is_a: GO:2000951 ! regulation of xyloglucan catabolic process
is_a: GO:2000989 ! negative regulation of hemicellulose catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:2000899 ! xyloglucan catabolic process
relationship: negatively_regulates GO:2000899 ! xyloglucan catabolic process
created_by: trudy
creation_date: 2011-08-01T02:20:21Z

[Term]
id: GO:2000953
name: positive regulation of xyloglucan catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of xyloglucan catabolic process." [GOC:mengo_curators]
synonym: "positive regulation of xyloglucan catabolism" EXACT [GOC:obol]
is_a: GO:2000950 ! positive regulation of xyloglucan metabolic process
is_a: GO:2000951 ! regulation of xyloglucan catabolic process
is_a: GO:2000990 ! positive regulation of hemicellulose catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:2000899 ! xyloglucan catabolic process
relationship: positively_regulates GO:2000899 ! xyloglucan catabolic process
created_by: trudy
creation_date: 2011-08-01T02:20:26Z

[Term]
id: GO:2000954
name: regulation of cyclodextrin metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cyclodextrin metabolic process." [GOC:mengo_curators]
synonym: "regulation of cyclodextrin metabolism" EXACT [GOC:obol]
is_a: GO:0032881 ! regulation of polysaccharide metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:2000900 ! cyclodextrin metabolic process
relationship: regulates GO:2000900 ! cyclodextrin metabolic process
created_by: trudy
creation_date: 2011-08-01T02:22:00Z

[Term]
id: GO:2000955
name: negative regulation of cyclodextrin metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cyclodextrin metabolic process." [GOC:mengo_curators]
synonym: "negative regulation of cyclodextrin metabolism" EXACT [GOC:obol]
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:2000954 ! regulation of cyclodextrin metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:2000900 ! cyclodextrin metabolic process
relationship: negatively_regulates GO:2000900 ! cyclodextrin metabolic process
created_by: trudy
creation_date: 2011-08-01T02:22:05Z

[Term]
id: GO:2000956
name: positive regulation of cyclodextrin metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cyclodextrin metabolic process." [GOC:mengo_curators]
synonym: "positive regulation of cyclodextrin metabolism" EXACT [GOC:obol]
is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process
is_a: GO:2000954 ! regulation of cyclodextrin metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:2000900 ! cyclodextrin metabolic process
relationship: positively_regulates GO:2000900 ! cyclodextrin metabolic process
created_by: trudy
creation_date: 2011-08-01T02:22:09Z

[Term]
id: GO:2000957
name: regulation of cyclodextrin catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cyclodextrin catabolic process." [GOC:mengo_curators]
synonym: "regulation of cyclodextrin catabolism" EXACT [GOC:obol]
is_a: GO:0043470 ! regulation of carbohydrate catabolic process
is_a: GO:2000954 ! regulation of cyclodextrin metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:2000901 ! cyclodextrin catabolic process
relationship: regulates GO:2000901 ! cyclodextrin catabolic process
created_by: trudy
creation_date: 2011-08-01T02:23:55Z

[Term]
id: GO:2000958
name: negative regulation of cyclodextrin catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cyclodextrin catabolic process." [GOC:mengo_curators]
synonym: "negative regulation of cyclodextrin catabolism" EXACT [GOC:obol]
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:2000955 ! negative regulation of cyclodextrin metabolic process
is_a: GO:2000957 ! regulation of cyclodextrin catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:2000901 ! cyclodextrin catabolic process
relationship: negatively_regulates GO:2000901 ! cyclodextrin catabolic process
created_by: trudy
creation_date: 2011-08-01T02:24:02Z

[Term]
id: GO:2000959
name: positive regulation of cyclodextrin catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cyclodextrin catabolic process." [GOC:mengo_curators]
synonym: "positive regulation of cyclodextrin catabolism" EXACT [GOC:obol]
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:2000956 ! positive regulation of cyclodextrin metabolic process
is_a: GO:2000957 ! regulation of cyclodextrin catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:2000901 ! cyclodextrin catabolic process
relationship: positively_regulates GO:2000901 ! cyclodextrin catabolic process
created_by: trudy
creation_date: 2011-08-01T02:24:06Z

[Term]
id: GO:2000960
name: regulation of cellooligosaccharide metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellooligosaccharide metabolic process." [GOC:mengo_curators]
synonym: "regulation of cellooligosaccharide metabolism" EXACT [GOC:obol]
is_a: GO:0006109 ! regulation of carbohydrate metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:2000902 ! cellooligosaccharide metabolic process
relationship: regulates GO:2000902 ! cellooligosaccharide metabolic process
created_by: trudy
creation_date: 2011-08-01T02:25:54Z

[Term]
id: GO:2000961
name: negative regulation of cellooligosaccharide metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellooligosaccharide metabolic process." [GOC:mengo_curators]
synonym: "negative regulation of cellooligosaccharide metabolism" EXACT [GOC:obol]
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:2000960 ! regulation of cellooligosaccharide metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:2000902 ! cellooligosaccharide metabolic process
relationship: negatively_regulates GO:2000902 ! cellooligosaccharide metabolic process
created_by: trudy
creation_date: 2011-08-01T02:25:59Z

[Term]
id: GO:2000962
name: positive regulation of cellooligosaccharide metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellooligosaccharide metabolic process." [GOC:mengo_curators]
synonym: "positive regulation of cellooligosaccharide metabolism" EXACT [GOC:obol]
is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process
is_a: GO:2000960 ! regulation of cellooligosaccharide metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:2000902 ! cellooligosaccharide metabolic process
relationship: positively_regulates GO:2000902 ! cellooligosaccharide metabolic process
created_by: trudy
creation_date: 2011-08-01T02:26:02Z

[Term]
id: GO:2000963
name: regulation of cellooligosaccharide catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellooligosaccharide catabolic process." [GOC:mengo_curators]
synonym: "regulation of cellooligosaccharide catabolism" EXACT [GOC:obol]
is_a: GO:0043470 ! regulation of carbohydrate catabolic process
is_a: GO:2000960 ! regulation of cellooligosaccharide metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:2000903 ! cellooligosaccharide catabolic process
relationship: regulates GO:2000903 ! cellooligosaccharide catabolic process
created_by: trudy
creation_date: 2011-08-01T02:28:36Z

[Term]
id: GO:2000964
name: negative regulation of cellooligosaccharide catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellooligosaccharide catabolic process." [GOC:mengo_curators]
synonym: "negative regulation of cellooligosaccharide catabolism" EXACT [GOC:obol]
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:2000961 ! negative regulation of cellooligosaccharide metabolic process
is_a: GO:2000963 ! regulation of cellooligosaccharide catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:2000903 ! cellooligosaccharide catabolic process
relationship: negatively_regulates GO:2000903 ! cellooligosaccharide catabolic process
created_by: trudy
creation_date: 2011-08-01T02:28:42Z

[Term]
id: GO:2000965
name: positive regulation of cellooligosaccharide catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellooligosaccharide catabolic process." [GOC:mengo_curators]
synonym: "positive regulation of cellooligosaccharide catabolism" EXACT [GOC:obol]
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:2000962 ! positive regulation of cellooligosaccharide metabolic process
is_a: GO:2000963 ! regulation of cellooligosaccharide catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:2000903 ! cellooligosaccharide catabolic process
relationship: positively_regulates GO:2000903 ! cellooligosaccharide catabolic process
created_by: trudy
creation_date: 2011-08-01T02:28:47Z

[Term]
id: GO:2000966
name: regulation of cell wall polysaccharide catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell wall polysaccharide catabolic process." [GOC:mengo_curators]
synonym: "regulation of cell wall polysaccharide breakdown" EXACT [GOC:obol]
is_a: GO:0010981 ! regulation of cell wall macromolecule metabolic process
is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:0032881 ! regulation of polysaccharide metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044347 ! cell wall polysaccharide catabolic process
relationship: regulates GO:0044347 ! cell wall polysaccharide catabolic process
created_by: trudy
creation_date: 2011-08-01T02:30:27Z

[Term]
id: GO:2000967
name: negative regulation of cell wall polysaccharide catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell wall polysaccharide catabolic process." [GOC:mengo_curators]
synonym: "negative regulation of cell wall polysaccharide breakdown" EXACT [GOC:obol]
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:1903339 ! negative regulation of cell wall organization or biogenesis
is_a: GO:2000966 ! regulation of cell wall polysaccharide catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044347 ! cell wall polysaccharide catabolic process
relationship: negatively_regulates GO:0044347 ! cell wall polysaccharide catabolic process
created_by: trudy
creation_date: 2011-08-01T02:30:33Z

[Term]
id: GO:2000968
name: positive regulation of cell wall polysaccharide catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell wall polysaccharide catabolic process." [GOC:mengo_curators]
synonym: "positive regulation of cell wall polysaccharide breakdown" EXACT [GOC:obol]
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process
is_a: GO:1903340 ! positive regulation of cell wall organization or biogenesis
is_a: GO:2000966 ! regulation of cell wall polysaccharide catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044347 ! cell wall polysaccharide catabolic process
relationship: positively_regulates GO:0044347 ! cell wall polysaccharide catabolic process
created_by: trudy
creation_date: 2011-08-01T02:30:37Z

[Term]
id: GO:2000969
name: positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity." [PMID:21423165]
synonym: "positive regulation of AMPA receptor activity" EXACT [GOC:obol]
is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity
is_a: GO:0050806 ! positive regulation of synaptic transmission
is_a: GO:1900451 ! positive regulation of glutamate receptor signaling pathway
is_a: GO:2000273 ! positive regulation of receptor activity
is_a: GO:2000311 ! regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004971 ! AMPA glutamate receptor activity
relationship: positively_regulates GO:0004971 ! AMPA glutamate receptor activity
created_by: pr
creation_date: 2011-08-03T10:27:08Z

[Term]
id: GO:2000970
name: regulation of detection of glucose
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of detection of glucose." [GOC:BHF]
synonym: "regulation of glucose detection" EXACT [GOC:obol]
synonym: "regulation of glucose perception" RELATED [GOC:obol]
synonym: "regulation of glucose sensing" RELATED [GOC:obol]
is_a: GO:0048583 ! regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051594 ! detection of glucose
relationship: regulates GO:0051594 ! detection of glucose
created_by: vk
creation_date: 2011-08-02T10:18:52Z

[Term]
id: GO:2000971
name: negative regulation of detection of glucose
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of detection of glucose." [GOC:BHF]
synonym: "negative regulation of glucose detection" EXACT [GOC:obol]
synonym: "negative regulation of glucose perception" RELATED [GOC:obol]
synonym: "negative regulation of glucose sensing" RELATED [GOC:obol]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:2000970 ! regulation of detection of glucose
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051594 ! detection of glucose
relationship: negatively_regulates GO:0051594 ! detection of glucose
created_by: vk
creation_date: 2011-08-02T10:18:54Z

[Term]
id: GO:2000972
name: positive regulation of detection of glucose
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of detection of glucose." [GOC:BHF]
synonym: "positive regulation of glucose detection" EXACT [GOC:obol]
synonym: "positive regulation of glucose perception" RELATED [GOC:obol]
synonym: "positive regulation of glucose sensing" RELATED [GOC:obol]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:2000970 ! regulation of detection of glucose
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051594 ! detection of glucose
relationship: positively_regulates GO:0051594 ! detection of glucose
created_by: vk
creation_date: 2011-08-02T10:18:56Z

[Term]
id: GO:2000973
name: regulation of pro-B cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pro-B cell differentiation." [GOC:obol]
synonym: "regulation of pro-B cell development" RELATED [GOC:obol]
synonym: "regulation of pro-B lymphocyte differentiation" EXACT [GOC:obol]
is_a: GO:1901532 ! regulation of hematopoietic progenitor cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002328 ! pro-B cell differentiation
relationship: regulates GO:0002328 ! pro-B cell differentiation
created_by: yaf
creation_date: 2011-08-02T03:05:45Z

[Term]
id: GO:2000974
name: negative regulation of pro-B cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of pro-B cell differentiation." [GOC:obol]
synonym: "negative regulation of pro-B cell development" RELATED [GOC:obol]
synonym: "negative regulation of pro-B lymphocyte differentiation" EXACT [GOC:obol]
is_a: GO:1901533 ! negative regulation of hematopoietic progenitor cell differentiation
is_a: GO:2000973 ! regulation of pro-B cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002328 ! pro-B cell differentiation
relationship: negatively_regulates GO:0002328 ! pro-B cell differentiation
created_by: yaf
creation_date: 2011-08-02T03:05:50Z

[Term]
id: GO:2000975
name: positive regulation of pro-B cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pro-B cell differentiation." [GOC:obol]
synonym: "positive regulation of pro-B cell development" RELATED [GOC:obol]
synonym: "positive regulation of pro-B lymphocyte differentiation" EXACT [GOC:obol]
is_a: GO:1901534 ! positive regulation of hematopoietic progenitor cell differentiation
is_a: GO:2000973 ! regulation of pro-B cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002328 ! pro-B cell differentiation
relationship: positively_regulates GO:0002328 ! pro-B cell differentiation
created_by: yaf
creation_date: 2011-08-02T03:05:53Z

[Term]
id: GO:2000976
name: obsolete regulation of transcription from RNA polymerase II promoter involved in detection of glucose
namespace: biological_process
def: "OBSOLETE. Any regulation of transcription from RNA polymerase II promoter that is involved in detection of glucose." [GOC:BHF]
comment: This term was made obolete is that in these terms the 'involved in' process is not truly involved_in (i.e. part_of) the process but instead is causally upstream of it. We advise replacing annotations to these terms with annotations + extensions using the causally_upstream_of relation e.g. P1234 regulation of gene expression [causally_upstream_of] extracellular matrix organization.
synonym: "global transcription regulation from Pol II promoter involved in detection of glucose" RELATED [GOC:obol]
synonym: "global transcription regulation from Pol II promoter involved in glucose detection" RELATED [GOC:obol]
synonym: "global transcription regulation from Pol II promoter involved in glucose perception" RELATED [GOC:obol]
synonym: "global transcription regulation from Pol II promoter involved in glucose sensing" RELATED [GOC:obol]
synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in detection of glucose" RELATED [GOC:obol]
synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in glucose detection" RELATED [GOC:obol]
synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in glucose perception" RELATED [GOC:obol]
synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in glucose sensing" RELATED [GOC:obol]
synonym: "regulation of global transcription from Pol II promoter involved in detection of glucose" RELATED [GOC:obol]
synonym: "regulation of global transcription from Pol II promoter involved in glucose detection" RELATED [GOC:obol]
synonym: "regulation of global transcription from Pol II promoter involved in glucose perception" RELATED [GOC:obol]
synonym: "regulation of global transcription from Pol II promoter involved in glucose sensing" RELATED [GOC:obol]
synonym: "regulation of transcription from Pol II promoter involved in detection of glucose" EXACT [GOC:obol]
synonym: "regulation of transcription from Pol II promoter involved in glucose detection" EXACT [GOC:obol]
synonym: "regulation of transcription from Pol II promoter involved in glucose perception" RELATED [GOC:obol]
synonym: "regulation of transcription from Pol II promoter involved in glucose sensing" RELATED [GOC:obol]
synonym: "regulation of transcription from RNA polymerase II promoter involved in glucose detection" EXACT [GOC:obol]
synonym: "regulation of transcription from RNA polymerase II promoter involved in glucose perception" RELATED [GOC:obol]
synonym: "regulation of transcription from RNA polymerase II promoter involved in glucose sensing" RELATED [GOC:obol]
synonym: "regulation of transcription from RNA polymerase II promoter, global involved in detection of glucose" RELATED [GOC:obol]
synonym: "regulation of transcription from RNA polymerase II promoter, global involved in glucose detection" RELATED [GOC:obol]
synonym: "regulation of transcription from RNA polymerase II promoter, global involved in glucose perception" RELATED [GOC:obol]
synonym: "regulation of transcription from RNA polymerase II promoter, global involved in glucose sensing" RELATED [GOC:obol]
is_obsolete: true
consider: GO:0051594
created_by: vk
creation_date: 2011-08-02T05:06:52Z

[Term]
id: GO:2000977
name: regulation of forebrain neuron differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of forebrain neuron differentiation." [GOC:obol]
is_a: GO:0045664 ! regulation of neuron differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0021879 ! forebrain neuron differentiation
relationship: regulates GO:0021879 ! forebrain neuron differentiation
created_by: yaf
creation_date: 2011-08-03T12:09:12Z

[Term]
id: GO:2000978
name: negative regulation of forebrain neuron differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of forebrain neuron differentiation." [GOC:obol]
is_a: GO:0045665 ! negative regulation of neuron differentiation
is_a: GO:2000977 ! regulation of forebrain neuron differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0021879 ! forebrain neuron differentiation
relationship: negatively_regulates GO:0021879 ! forebrain neuron differentiation
created_by: yaf
creation_date: 2011-08-03T12:09:16Z

[Term]
id: GO:2000979
name: positive regulation of forebrain neuron differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of forebrain neuron differentiation." [GOC:obol]
is_a: GO:0045666 ! positive regulation of neuron differentiation
is_a: GO:2000977 ! regulation of forebrain neuron differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0021879 ! forebrain neuron differentiation
relationship: positively_regulates GO:0021879 ! forebrain neuron differentiation
created_by: yaf
creation_date: 2011-08-03T12:09:19Z

[Term]
id: GO:2000980
name: regulation of inner ear receptor cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of inner ear receptor cell differentiation." [GOC:obol]
synonym: "regulation of inner ear hair cell differentiation" EXACT [GOC:obol]
is_a: GO:0045631 ! regulation of mechanoreceptor differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060113 ! inner ear receptor cell differentiation
relationship: regulates GO:0060113 ! inner ear receptor cell differentiation
created_by: yaf
creation_date: 2011-08-03T02:38:43Z

[Term]
id: GO:2000981
name: negative regulation of inner ear receptor cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of inner ear receptor cell differentiation." [GOC:obol]
synonym: "negative regulation of inner ear hair cell differentiation" EXACT [GOC:obol]
is_a: GO:0045632 ! negative regulation of mechanoreceptor differentiation
is_a: GO:2000980 ! regulation of inner ear receptor cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060113 ! inner ear receptor cell differentiation
relationship: negatively_regulates GO:0060113 ! inner ear receptor cell differentiation
created_by: yaf
creation_date: 2011-08-03T02:38:47Z

[Term]
id: GO:2000982
name: positive regulation of inner ear receptor cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of inner ear receptor cell differentiation." [GOC:obol]
synonym: "positive regulation of inner ear hair cell differentiation" EXACT [GOC:obol]
is_a: GO:0045633 ! positive regulation of mechanoreceptor differentiation
is_a: GO:2000980 ! regulation of inner ear receptor cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060113 ! inner ear receptor cell differentiation
relationship: positively_regulates GO:0060113 ! inner ear receptor cell differentiation
created_by: yaf
creation_date: 2011-08-03T02:38:51Z

[Term]
id: GO:2000983
name: regulation of ATP citrate synthase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ATP citrate synthase activity." [GOC:BHF]
synonym: "regulation of acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP- phosphorylating) activity" EXACT [GOC:obol]
synonym: "regulation of acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP-phosphorylating)" EXACT [GOC:obol]
synonym: "regulation of acetyl-CoA:oxaloacetate C-acetyltransferase [(pro-S)-carboxymethyl-forming, ADP-phosphorylating]" RELATED [GOC:obol]
synonym: "regulation of adenosine triphosphate citrate lyase activity" EXACT [GOC:obol]
synonym: "regulation of ATP citrate (pro-S)-lyase activity" EXACT [GOC:obol]
synonym: "regulation of ATP-citrate (pro-S)-lyase activity" EXACT [GOC:obol]
synonym: "regulation of ATP-citrate (pro-S-)-lyase activity" EXACT [GOC:obol]
synonym: "regulation of ATP-citric lyase activity" EXACT [GOC:obol]
synonym: "regulation of ATP:citrate oxaloacetate-lyase ((pro-S)-CH(2)COO(-)->acetyl-CoA) (ATP- dephosphorylating) activity" EXACT [GOC:obol]
synonym: "regulation of ATP:citrate oxaloacetate-lyase [(pro-S)-CH2COO-rightacetyl-CoA] (ATP-dephosphorylating)" RELATED [GOC:obol]
synonym: "regulation of citrate cleavage enzyme activity" RELATED [GOC:obol]
synonym: "regulation of citrate-ATP lyase activity" EXACT [GOC:obol]
synonym: "regulation of citric cleavage enzyme activity" RELATED [GOC:obol]
is_a: GO:0051338 ! regulation of transferase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003878 ! ATP citrate synthase activity
relationship: regulates GO:0003878 ! ATP citrate synthase activity
created_by: vk
creation_date: 2011-08-04T03:15:24Z

[Term]
id: GO:2000984
name: negative regulation of ATP citrate synthase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ATP citrate synthase activity." [GOC:BHF]
synonym: "negative regulation of acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP- phosphorylating) activity" EXACT [GOC:obol]
synonym: "negative regulation of acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP-phosphorylating)" EXACT [GOC:obol]
synonym: "negative regulation of acetyl-CoA:oxaloacetate C-acetyltransferase [(pro-S)-carboxymethyl-forming, ADP-phosphorylating]" RELATED [GOC:obol]
synonym: "negative regulation of adenosine triphosphate citrate lyase activity" EXACT [GOC:obol]
synonym: "negative regulation of ATP citrate (pro-S)-lyase activity" EXACT [GOC:obol]
synonym: "negative regulation of ATP-citrate (pro-S)-lyase activity" EXACT [GOC:obol]
synonym: "negative regulation of ATP-citrate (pro-S-)-lyase activity" EXACT [GOC:obol]
synonym: "negative regulation of ATP-citric lyase activity" EXACT [GOC:obol]
synonym: "negative regulation of ATP:citrate oxaloacetate-lyase ((pro-S)-CH(2)COO(-)->acetyl-CoA) (ATP- dephosphorylating) activity" EXACT [GOC:obol]
synonym: "negative regulation of ATP:citrate oxaloacetate-lyase [(pro-S)-CH2COO-rightacetyl-CoA] (ATP-dephosphorylating)" RELATED [GOC:obol]
synonym: "negative regulation of citrate cleavage enzyme activity" RELATED [GOC:obol]
synonym: "negative regulation of citrate-ATP lyase activity" EXACT [GOC:obol]
synonym: "negative regulation of citric cleavage enzyme activity" RELATED [GOC:obol]
is_a: GO:0051348 ! negative regulation of transferase activity
is_a: GO:2000983 ! regulation of ATP citrate synthase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003878 ! ATP citrate synthase activity
relationship: negatively_regulates GO:0003878 ! ATP citrate synthase activity
created_by: vk
creation_date: 2011-08-04T03:15:28Z

[Term]
id: GO:2000985
name: positive regulation of ATP citrate synthase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ATP citrate synthase activity." [GOC:BHF]
synonym: "positive regulation of acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP- phosphorylating) activity" EXACT [GOC:obol]
synonym: "positive regulation of acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP-phosphorylating)" EXACT [GOC:obol]
synonym: "positive regulation of acetyl-CoA:oxaloacetate C-acetyltransferase [(pro-S)-carboxymethyl-forming, ADP-phosphorylating]" RELATED [GOC:obol]
synonym: "positive regulation of adenosine triphosphate citrate lyase activity" EXACT [GOC:obol]
synonym: "positive regulation of ATP citrate (pro-S)-lyase activity" EXACT [GOC:obol]
synonym: "positive regulation of ATP-citrate (pro-S)-lyase activity" EXACT [GOC:obol]
synonym: "positive regulation of ATP-citrate (pro-S-)-lyase activity" EXACT [GOC:obol]
synonym: "positive regulation of ATP-citric lyase activity" EXACT [GOC:obol]
synonym: "positive regulation of ATP:citrate oxaloacetate-lyase ((pro-S)-CH(2)COO(-)->acetyl-CoA) (ATP- dephosphorylating) activity" EXACT [GOC:obol]
synonym: "positive regulation of ATP:citrate oxaloacetate-lyase [(pro-S)-CH2COO-rightacetyl-CoA] (ATP-dephosphorylating)" RELATED [GOC:obol]
synonym: "positive regulation of citrate cleavage enzyme activity" RELATED [GOC:obol]
synonym: "positive regulation of citrate-ATP lyase activity" EXACT [GOC:obol]
synonym: "positive regulation of citric cleavage enzyme activity" RELATED [GOC:obol]
is_a: GO:0051347 ! positive regulation of transferase activity
is_a: GO:2000983 ! regulation of ATP citrate synthase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003878 ! ATP citrate synthase activity
relationship: positively_regulates GO:0003878 ! ATP citrate synthase activity
created_by: vk
creation_date: 2011-08-04T03:15:31Z

[Term]
id: GO:2000986
name: negative regulation of behavioral fear response
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of behavioral fear response." [GOC:obol]
synonym: "negative regulation of behavioural fear response" EXACT [GOC:obol]
is_a: GO:0031348 ! negative regulation of defense response
is_a: GO:0048521 ! negative regulation of behavior
is_a: GO:1903366 ! negative regulation of fear response
is_a: GO:2000822 ! regulation of behavioral fear response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001662 ! behavioral fear response
relationship: negatively_regulates GO:0001662 ! behavioral fear response
created_by: yaf
creation_date: 2011-08-08T09:16:34Z

[Term]
id: GO:2000987
name: positive regulation of behavioral fear response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of behavioral fear response." [GOC:obol]
synonym: "positive regulation of behavioural fear response" EXACT [GOC:obol]
is_a: GO:0031349 ! positive regulation of defense response
is_a: GO:0048520 ! positive regulation of behavior
is_a: GO:1903367 ! positive regulation of fear response
is_a: GO:2000822 ! regulation of behavioral fear response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001662 ! behavioral fear response
relationship: positively_regulates GO:0001662 ! behavioral fear response
created_by: yaf
creation_date: 2011-08-08T09:16:39Z

[Term]
id: GO:2000988
name: regulation of hemicellulose catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hemicellulose catabolic process." [GOC:mengo_curators]
synonym: "regulation of hemicellulose catabolism" EXACT [GOC:obol]
is_a: GO:0010981 ! regulation of cell wall macromolecule metabolic process
is_a: GO:0032881 ! regulation of polysaccharide metabolic process
is_a: GO:0043470 ! regulation of carbohydrate catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:2000895 ! hemicellulose catabolic process
relationship: regulates GO:2000895 ! hemicellulose catabolic process
created_by: trudy
creation_date: 2011-08-08T03:08:16Z

[Term]
id: GO:2000989
name: negative regulation of hemicellulose catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hemicellulose catabolic process." [GOC:mengo_curators]
synonym: "negative regulation of hemicellulose catabolism" EXACT [GOC:obol]
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:1903339 ! negative regulation of cell wall organization or biogenesis
is_a: GO:2000988 ! regulation of hemicellulose catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:2000895 ! hemicellulose catabolic process
relationship: negatively_regulates GO:2000895 ! hemicellulose catabolic process
created_by: trudy
creation_date: 2011-08-08T03:08:20Z

[Term]
id: GO:2000990
name: positive regulation of hemicellulose catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hemicellulose catabolic process." [GOC:mengo_curators]
synonym: "positive regulation of hemicellulose catabolism" EXACT [GOC:obol]
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process
is_a: GO:1903340 ! positive regulation of cell wall organization or biogenesis
is_a: GO:2000988 ! regulation of hemicellulose catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:2000895 ! hemicellulose catabolic process
relationship: positively_regulates GO:2000895 ! hemicellulose catabolic process
created_by: trudy
creation_date: 2011-08-08T03:08:23Z

[Term]
id: GO:2000991
name: regulation of galactomannan catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of galactomannan catabolic process." [GOC:mengo_curators]
is_a: GO:0032881 ! regulation of polysaccharide metabolic process
is_a: GO:0043470 ! regulation of carbohydrate catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051682 ! galactomannan catabolic process
relationship: regulates GO:0051682 ! galactomannan catabolic process
created_by: trudy
creation_date: 2011-08-08T03:15:53Z

[Term]
id: GO:2000992
name: negative regulation of galactomannan catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of galactomannan catabolic process." [GOC:mengo_curators]
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:2000991 ! regulation of galactomannan catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051682 ! galactomannan catabolic process
relationship: negatively_regulates GO:0051682 ! galactomannan catabolic process
created_by: trudy
creation_date: 2011-08-08T03:16:00Z

[Term]
id: GO:2000993
name: positive regulation of galactomannan catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of galactomannan catabolic process." [GOC:mengo_curators]
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process
is_a: GO:2000991 ! regulation of galactomannan catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051682 ! galactomannan catabolic process
relationship: positively_regulates GO:0051682 ! galactomannan catabolic process
created_by: trudy
creation_date: 2011-08-08T03:16:07Z

[Term]
id: GO:2000994
name: regulation of mannan catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mannan catabolic process." [GOC:mengo_curators]
synonym: "regulation of mannan breakdown" EXACT [GOC:obol]
synonym: "regulation of mannan catabolism" EXACT [GOC:obol]
synonym: "regulation of mannan degradation" EXACT [GOC:obol]
is_a: GO:0010981 ! regulation of cell wall macromolecule metabolic process
is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process
is_a: GO:2000924 ! regulation of cellodextrin metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0046355 ! mannan catabolic process
relationship: regulates GO:0046355 ! mannan catabolic process
created_by: trudy
creation_date: 2011-08-08T03:19:03Z

[Term]
id: GO:2000995
name: negative regulation of mannan catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mannan catabolic process." [GOC:mengo_curators]
synonym: "negative regulation of mannan breakdown" EXACT [GOC:obol]
synonym: "negative regulation of mannan catabolism" EXACT [GOC:obol]
synonym: "negative regulation of mannan degradation" EXACT [GOC:obol]
is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:1903339 ! negative regulation of cell wall organization or biogenesis
is_a: GO:2000925 ! negative regulation of cellodextrin metabolic process
is_a: GO:2000994 ! regulation of mannan catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0046355 ! mannan catabolic process
relationship: negatively_regulates GO:0046355 ! mannan catabolic process
created_by: trudy
creation_date: 2011-08-08T03:19:11Z

[Term]
id: GO:2000996
name: positive regulation of mannan catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mannan catabolic process." [GOC:mengo_curators]
synonym: "positive regulation of mannan breakdown" EXACT [GOC:obol]
synonym: "positive regulation of mannan catabolism" EXACT [GOC:obol]
synonym: "positive regulation of mannan degradation" EXACT [GOC:obol]
is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:1903340 ! positive regulation of cell wall organization or biogenesis
is_a: GO:2000926 ! positive regulation of cellodextrin metabolic process
is_a: GO:2000994 ! regulation of mannan catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0046355 ! mannan catabolic process
relationship: positively_regulates GO:0046355 ! mannan catabolic process
created_by: trudy
creation_date: 2011-08-08T03:19:18Z

[Term]
id: GO:2000997
name: regulation of cellulose catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellulose catabolic process." [GOC:mengo_curators]
synonym: "regulation of cellulose breakdown" EXACT [GOC:obol]
synonym: "regulation of cellulose catabolism" EXACT [GOC:obol]
synonym: "regulation of cellulose degradation" EXACT [GOC:obol]
is_a: GO:0032950 ! regulation of beta-glucan metabolic process
is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030245 ! cellulose catabolic process
relationship: regulates GO:0030245 ! cellulose catabolic process
created_by: trudy
creation_date: 2011-08-08T03:21:20Z

[Term]
id: GO:2000998
name: negative regulation of cellulose catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellulose catabolic process." [GOC:mengo_curators]
synonym: "negative regulation of cellulose breakdown" EXACT [GOC:obol]
synonym: "negative regulation of cellulose catabolism" EXACT [GOC:obol]
synonym: "negative regulation of cellulose degradation" EXACT [GOC:obol]
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:2000997 ! regulation of cellulose catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030245 ! cellulose catabolic process
relationship: negatively_regulates GO:0030245 ! cellulose catabolic process
created_by: trudy
creation_date: 2011-08-08T03:21:26Z

[Term]
id: GO:2000999
name: positive regulation of cellulose catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellulose catabolic process." [GOC:mengo_curators]
synonym: "positive regulation of cellulose breakdown" EXACT [GOC:obol]
synonym: "positive regulation of cellulose catabolism" EXACT [GOC:obol]
synonym: "positive regulation of cellulose degradation" EXACT [GOC:obol]
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:2000997 ! regulation of cellulose catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030245 ! cellulose catabolic process
relationship: positively_regulates GO:0030245 ! cellulose catabolic process
created_by: trudy
creation_date: 2011-08-08T03:21:30Z

[Term]
id: GO:2001000
name: regulation of xylan catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of xylan catabolic process." [GOC:mengo_curators]
synonym: "regulation of xylan breakdown" EXACT [GOC:obol]
synonym: "regulation of xylan catabolism" EXACT [GOC:obol]
synonym: "regulation of xylan degradation" EXACT [GOC:obol]
is_a: GO:0010981 ! regulation of cell wall macromolecule metabolic process
is_a: GO:0043470 ! regulation of carbohydrate catabolic process
is_a: GO:2000924 ! regulation of cellodextrin metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045493 ! xylan catabolic process
relationship: regulates GO:0045493 ! xylan catabolic process
created_by: trudy
creation_date: 2011-08-08T03:23:13Z

[Term]
id: GO:2001001
name: negative regulation of xylan catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of xylan catabolic process." [GOC:mengo_curators]
synonym: "negative regulation of xylan breakdown" EXACT [GOC:obol]
synonym: "negative regulation of xylan catabolism" EXACT [GOC:obol]
synonym: "negative regulation of xylan degradation" EXACT [GOC:obol]
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:1903339 ! negative regulation of cell wall organization or biogenesis
is_a: GO:2000925 ! negative regulation of cellodextrin metabolic process
is_a: GO:2001000 ! regulation of xylan catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045493 ! xylan catabolic process
relationship: negatively_regulates GO:0045493 ! xylan catabolic process
created_by: trudy
creation_date: 2011-08-08T03:23:18Z

[Term]
id: GO:2001002
name: positive regulation of xylan catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of xylan catabolic process." [GOC:mengo_curators]
synonym: "positive regulation of xylan breakdown" EXACT [GOC:obol]
synonym: "positive regulation of xylan catabolism" EXACT [GOC:obol]
synonym: "positive regulation of xylan degradation" EXACT [GOC:obol]
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:1903340 ! positive regulation of cell wall organization or biogenesis
is_a: GO:2000926 ! positive regulation of cellodextrin metabolic process
is_a: GO:2001000 ! regulation of xylan catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045493 ! xylan catabolic process
relationship: positively_regulates GO:0045493 ! xylan catabolic process
created_by: trudy
creation_date: 2011-08-08T03:23:22Z

[Term]
id: GO:2001003
name: regulation of pectin catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pectin catabolic process." [GOC:mengo_curators]
synonym: "regulation of pectin breakdown" EXACT [GOC:obol]
synonym: "regulation of pectin catabolism" EXACT [GOC:obol]
synonym: "regulation of pectin degradation" EXACT [GOC:obol]
is_a: GO:0032881 ! regulation of polysaccharide metabolic process
is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045490 ! pectin catabolic process
relationship: regulates GO:0045490 ! pectin catabolic process
created_by: trudy
creation_date: 2011-08-08T03:24:01Z

[Term]
id: GO:2001004
name: negative regulation of pectin catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of pectin catabolic process." [GOC:mengo_curators]
synonym: "negative regulation of pectin breakdown" EXACT [GOC:obol]
synonym: "negative regulation of pectin catabolism" EXACT [GOC:obol]
synonym: "negative regulation of pectin degradation" EXACT [GOC:obol]
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process
is_a: GO:2001003 ! regulation of pectin catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045490 ! pectin catabolic process
relationship: negatively_regulates GO:0045490 ! pectin catabolic process
created_by: trudy
creation_date: 2011-08-08T03:24:06Z

[Term]
id: GO:2001005
name: positive regulation of pectin catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pectin catabolic process." [GOC:mengo_curators]
synonym: "positive regulation of pectin breakdown" EXACT [GOC:obol]
synonym: "positive regulation of pectin catabolism" EXACT [GOC:obol]
synonym: "positive regulation of pectin degradation" EXACT [GOC:obol]
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process
is_a: GO:2001003 ! regulation of pectin catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045490 ! pectin catabolic process
relationship: positively_regulates GO:0045490 ! pectin catabolic process
created_by: trudy
creation_date: 2011-08-08T03:24:09Z

[Term]
id: GO:2001006
name: regulation of cellulose biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellulose biosynthetic process." [GOC:mengo_curators]
synonym: "regulation of cellulose anabolism" EXACT [GOC:obol]
synonym: "regulation of cellulose biosynthesis" EXACT [GOC:obol]
synonym: "regulation of cellulose formation" EXACT [GOC:obol]
synonym: "regulation of cellulose synthesis" EXACT [GOC:obol]
is_a: GO:0032951 ! regulation of beta-glucan biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030244 ! cellulose biosynthetic process
relationship: regulates GO:0030244 ! cellulose biosynthetic process
created_by: trudy
creation_date: 2011-08-08T08:42:17Z

[Term]
id: GO:2001007
name: negative regulation of cellulose biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellulose biosynthetic process." [GOC:mengo_curators]
synonym: "negative regulation of cellulose anabolism" EXACT [GOC:obol]
synonym: "negative regulation of cellulose biosynthesis" EXACT [GOC:obol]
synonym: "negative regulation of cellulose formation" EXACT [GOC:obol]
synonym: "negative regulation of cellulose synthesis" EXACT [GOC:obol]
is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process
is_a: GO:2000113 ! negative regulation of cellular macromolecule biosynthetic process
is_a: GO:2001006 ! regulation of cellulose biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030244 ! cellulose biosynthetic process
relationship: negatively_regulates GO:0030244 ! cellulose biosynthetic process
created_by: trudy
creation_date: 2011-08-08T08:42:24Z

[Term]
id: GO:2001008
name: positive regulation of cellulose biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellulose biosynthetic process." [GOC:mengo_curators]
synonym: "positive regulation of cellulose anabolism" EXACT [GOC:obol]
synonym: "positive regulation of cellulose biosynthesis" EXACT [GOC:obol]
synonym: "positive regulation of cellulose formation" EXACT [GOC:obol]
synonym: "positive regulation of cellulose synthesis" EXACT [GOC:obol]
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:2001006 ! regulation of cellulose biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030244 ! cellulose biosynthetic process
relationship: positively_regulates GO:0030244 ! cellulose biosynthetic process
created_by: trudy
creation_date: 2011-08-08T08:42:29Z

[Term]
id: GO:2001009
name: regulation of plant-type cell wall cellulose biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of plant-type cell wall cellulose biosynthetic process." [GOC:mengo_curators]
synonym: "regulation of cell wall cellulose biosynthesis" EXACT [GOC:obol]
synonym: "regulation of cellulose biosynthesis during cell wall biosynthesis" RELATED [GOC:obol]
is_a: GO:0010981 ! regulation of cell wall macromolecule metabolic process
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0051128 ! regulation of cellular component organization
is_a: GO:2001006 ! regulation of cellulose biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0052324 ! plant-type cell wall cellulose biosynthetic process
relationship: regulates GO:0052324 ! plant-type cell wall cellulose biosynthetic process
created_by: trudy
creation_date: 2011-08-08T08:47:15Z

[Term]
id: GO:2001010
name: negative regulation of plant-type cell wall cellulose biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of plant-type cell wall cellulose biosynthetic process." [GOC:mengo_curators]
synonym: "negative regulation of cell wall cellulose biosynthesis" EXACT [GOC:obol]
synonym: "negative regulation of cellulose biosynthesis during cell wall biosynthesis" RELATED [GOC:obol]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1903339 ! negative regulation of cell wall organization or biogenesis
is_a: GO:2001007 ! negative regulation of cellulose biosynthetic process
is_a: GO:2001009 ! regulation of plant-type cell wall cellulose biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0052324 ! plant-type cell wall cellulose biosynthetic process
relationship: negatively_regulates GO:0052324 ! plant-type cell wall cellulose biosynthetic process
created_by: trudy
creation_date: 2011-08-08T08:47:22Z

[Term]
id: GO:2001011
name: positive regulation of plant-type cell wall cellulose biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of plant-type cell wall cellulose biosynthetic process." [GOC:mengo_curators]
synonym: "positive regulation of cell wall cellulose biosynthesis" EXACT [GOC:obol]
synonym: "positive regulation of cellulose biosynthesis during cell wall biosynthesis" RELATED [GOC:obol]
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1903340 ! positive regulation of cell wall organization or biogenesis
is_a: GO:2001008 ! positive regulation of cellulose biosynthetic process
is_a: GO:2001009 ! regulation of plant-type cell wall cellulose biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0052324 ! plant-type cell wall cellulose biosynthetic process
relationship: positively_regulates GO:0052324 ! plant-type cell wall cellulose biosynthetic process
created_by: trudy
creation_date: 2011-08-08T08:47:30Z

[Term]
id: GO:2001012
name: mesenchymal cell differentiation involved in renal system development
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the renal system as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf]
synonym: "mesenchymal cell differentiation involved in urinary system development" RELATED [GOC:obol]
synonym: "mesenchymal cell differentiation involved in urinary tract development" RELATED [GOC:obol]
is_a: GO:0048762 ! mesenchymal cell differentiation
intersection_of: GO:0048762 ! mesenchymal cell differentiation
intersection_of: part_of GO:0072001 ! renal system development
relationship: part_of GO:0072001 ! renal system development
created_by: yaf
creation_date: 2011-08-09T04:05:14Z

[Term]
id: GO:2001013
name: epithelial cell proliferation involved in renal tubule morphogenesis
namespace: biological_process
def: "Any epithelial cell proliferation that is involved in renal tubule morphogenesis." [GOC:obol]
is_a: GO:0050673 ! epithelial cell proliferation
intersection_of: GO:0050673 ! epithelial cell proliferation
intersection_of: part_of GO:0061333 ! renal tubule morphogenesis
relationship: part_of GO:0061333 ! renal tubule morphogenesis
created_by: yaf
creation_date: 2011-08-12T11:37:29Z

[Term]
id: GO:2001014
name: regulation of skeletal muscle cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle cell differentiation." [GOC:obol]
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:0048641 ! regulation of skeletal muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035914 ! skeletal muscle cell differentiation
relationship: regulates GO:0035914 ! skeletal muscle cell differentiation
created_by: yaf
creation_date: 2011-08-11T08:54:37Z

[Term]
id: GO:2001015
name: negative regulation of skeletal muscle cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle cell differentiation." [GOC:obol]
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0048642 ! negative regulation of skeletal muscle tissue development
is_a: GO:2001014 ! regulation of skeletal muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035914 ! skeletal muscle cell differentiation
relationship: negatively_regulates GO:0035914 ! skeletal muscle cell differentiation
created_by: yaf
creation_date: 2011-08-11T08:54:41Z

[Term]
id: GO:2001016
name: positive regulation of skeletal muscle cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of skeletal muscle cell differentiation." [GOC:obol]
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0048643 ! positive regulation of skeletal muscle tissue development
is_a: GO:2001014 ! regulation of skeletal muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035914 ! skeletal muscle cell differentiation
relationship: positively_regulates GO:0035914 ! skeletal muscle cell differentiation
created_by: yaf
creation_date: 2011-08-11T08:54:44Z

[Term]
id: GO:2001017
name: regulation of retrograde axon cargo transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of retrograde axon cargo transport." [GOC:obol]
synonym: "regulation of retrograde axonal transport" EXACT [GOC:obol]
is_a: GO:0032386 ! regulation of intracellular transport
is_a: GO:0060632 ! regulation of microtubule-based movement
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008090 ! retrograde axonal transport
relationship: regulates GO:0008090 ! retrograde axonal transport
created_by: kmv
creation_date: 2011-08-11T09:44:42Z

[Term]
id: GO:2001018
name: negative regulation of retrograde axon cargo transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of retrograde axon cargo transport." [GOC:obol]
synonym: "negative regulation of retrograde axonal transport" EXACT [GOC:obol]
is_a: GO:0032387 ! negative regulation of intracellular transport
is_a: GO:0051271 ! negative regulation of cellular component movement
is_a: GO:2001017 ! regulation of retrograde axon cargo transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008090 ! retrograde axonal transport
relationship: negatively_regulates GO:0008090 ! retrograde axonal transport
created_by: kmv
creation_date: 2011-08-11T09:44:46Z

[Term]
id: GO:2001019
name: positive regulation of retrograde axon cargo transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of retrograde axon cargo transport." [GOC:obol]
synonym: "positive regulation of retrograde axonal transport" EXACT [GOC:obol]
is_a: GO:0032388 ! positive regulation of intracellular transport
is_a: GO:0051272 ! positive regulation of cellular component movement
is_a: GO:2001017 ! regulation of retrograde axon cargo transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008090 ! retrograde axonal transport
relationship: positively_regulates GO:0008090 ! retrograde axonal transport
created_by: kmv
creation_date: 2011-08-11T09:44:49Z

[Term]
id: GO:2001020
name: regulation of response to DNA damage stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to DNA damage stimulus." [GOC:obol]
synonym: "regulation of cellular DNA damage response" EXACT [GOC:obol]
synonym: "regulation of cellular response to DNA damage stimulus" EXACT [GOC:obol]
synonym: "regulation of DNA damage response" EXACT [GOC:obol]
synonym: "regulation of response to genotoxic stress" EXACT [GOC:obol]
is_a: GO:0080135 ! regulation of cellular response to stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006974 ! cellular response to DNA damage stimulus
relationship: regulates GO:0006974 ! cellular response to DNA damage stimulus
created_by: yaf
creation_date: 2011-08-19T10:20:25Z

[Term]
id: GO:2001021
name: negative regulation of response to DNA damage stimulus
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to DNA damage stimulus." [GOC:obol]
synonym: "negative regulation of cellular DNA damage response" EXACT [GOC:obol]
synonym: "negative regulation of cellular response to DNA damage stimulus" EXACT [GOC:obol]
synonym: "negative regulation of DNA damage response" EXACT [GOC:obol]
synonym: "negative regulation of response to genotoxic stress" EXACT [GOC:obol]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:2001020 ! regulation of response to DNA damage stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006974 ! cellular response to DNA damage stimulus
relationship: negatively_regulates GO:0006974 ! cellular response to DNA damage stimulus
created_by: yaf
creation_date: 2011-08-19T10:20:29Z

[Term]
id: GO:2001022
name: positive regulation of response to DNA damage stimulus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to DNA damage stimulus." [GOC:obol]
synonym: "positive regulation of cellular DNA damage response" EXACT [GOC:obol]
synonym: "positive regulation of cellular response to DNA damage stimulus" EXACT [GOC:obol]
synonym: "positive regulation of DNA damage response" EXACT [GOC:obol]
synonym: "positive regulation of response to genotoxic stress" EXACT [GOC:obol]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:2001020 ! regulation of response to DNA damage stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006974 ! cellular response to DNA damage stimulus
relationship: positively_regulates GO:0006974 ! cellular response to DNA damage stimulus
created_by: yaf
creation_date: 2011-08-19T10:20:33Z

[Term]
id: GO:2001023
name: regulation of response to drug
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to drug." [GOC:obol]
synonym: "regulation of drug resistance" RELATED [GOC:obol]
synonym: "regulation of drug susceptibility/resistance" RELATED [GOC:obol]
is_a: GO:0048583 ! regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042493 ! response to drug
relationship: regulates GO:0042493 ! response to drug
created_by: yaf
creation_date: 2011-08-19T01:47:20Z

[Term]
id: GO:2001024
name: negative regulation of response to drug
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to drug." [GOC:obol]
synonym: "negative regulation of drug resistance" RELATED [GOC:obol]
synonym: "negative regulation of drug susceptibility/resistance" RELATED [GOC:obol]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:2001023 ! regulation of response to drug
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042493 ! response to drug
relationship: negatively_regulates GO:0042493 ! response to drug
created_by: yaf
creation_date: 2011-08-19T01:47:24Z

[Term]
id: GO:2001025
name: positive regulation of response to drug
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to drug." [GOC:obol]
synonym: "positive regulation of drug resistance" RELATED [GOC:obol]
synonym: "positive regulation of drug susceptibility/resistance" RELATED [GOC:obol]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:2001023 ! regulation of response to drug
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042493 ! response to drug
relationship: positively_regulates GO:0042493 ! response to drug
created_by: yaf
creation_date: 2011-08-19T01:47:27Z

[Term]
id: GO:2001026
name: regulation of endothelial cell chemotaxis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endothelial cell chemotaxis." [GOC:BHF]
is_a: GO:0010594 ! regulation of endothelial cell migration
is_a: GO:0050920 ! regulation of chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035767 ! endothelial cell chemotaxis
relationship: regulates GO:0035767 ! endothelial cell chemotaxis
created_by: rl
creation_date: 2011-08-22T01:07:26Z

[Term]
id: GO:2001027
name: negative regulation of endothelial cell chemotaxis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell chemotaxis." [GOC:BHF]
is_a: GO:0010596 ! negative regulation of endothelial cell migration
is_a: GO:0050922 ! negative regulation of chemotaxis
is_a: GO:2001026 ! regulation of endothelial cell chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035767 ! endothelial cell chemotaxis
relationship: negatively_regulates GO:0035767 ! endothelial cell chemotaxis
created_by: rl
creation_date: 2011-08-22T01:07:31Z

[Term]
id: GO:2001028
name: positive regulation of endothelial cell chemotaxis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis." [GOC:BHF]
is_a: GO:0010595 ! positive regulation of endothelial cell migration
is_a: GO:0050921 ! positive regulation of chemotaxis
is_a: GO:2001026 ! regulation of endothelial cell chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035767 ! endothelial cell chemotaxis
relationship: positively_regulates GO:0035767 ! endothelial cell chemotaxis
created_by: rl
creation_date: 2011-08-22T01:07:34Z

[Term]
id: GO:2001029
name: regulation of cellular glucuronidation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular glucuronidation." [GOC:BHF]
synonym: "regulation of cellular glucuronide biosynthesis" EXACT [GOC:obol]
synonym: "regulation of cellular glucuronide biosynthetic process" EXACT [GOC:obol]
synonym: "regulation of cellular glucuronoside biosynthesis" EXACT [GOC:obol]
synonym: "regulation of cellular glucuronoside biosynthetic process" EXACT [GOC:obol]
is_a: GO:0010565 ! regulation of cellular ketone metabolic process
is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0052695 ! cellular glucuronidation
relationship: regulates GO:0052695 ! cellular glucuronidation
created_by: rl
creation_date: 2011-08-22T01:10:52Z

[Term]
id: GO:2001030
name: negative regulation of cellular glucuronidation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular glucuronidation." [GOC:BHF]
synonym: "negative regulation of cellular glucuronide biosynthesis" EXACT [GOC:obol]
synonym: "negative regulation of cellular glucuronide biosynthetic process" EXACT [GOC:obol]
synonym: "negative regulation of cellular glucuronoside biosynthesis" EXACT [GOC:obol]
synonym: "negative regulation of cellular glucuronoside biosynthetic process" EXACT [GOC:obol]
is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process
is_a: GO:2001029 ! regulation of cellular glucuronidation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0052695 ! cellular glucuronidation
relationship: negatively_regulates GO:0052695 ! cellular glucuronidation
created_by: rl
creation_date: 2011-08-22T01:10:56Z

[Term]
id: GO:2001031
name: positive regulation of cellular glucuronidation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellular glucuronidation." [GOC:BHF]
synonym: "positive regulation of cellular glucuronide biosynthesis" EXACT [GOC:obol]
synonym: "positive regulation of cellular glucuronide biosynthetic process" EXACT [GOC:obol]
synonym: "positive regulation of cellular glucuronoside biosynthesis" EXACT [GOC:obol]
synonym: "positive regulation of cellular glucuronoside biosynthetic process" EXACT [GOC:obol]
is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process
is_a: GO:2001029 ! regulation of cellular glucuronidation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0052695 ! cellular glucuronidation
relationship: positively_regulates GO:0052695 ! cellular glucuronidation
created_by: rl
creation_date: 2011-08-22T01:10:59Z

[Term]
id: GO:2001032
name: regulation of double-strand break repair via nonhomologous end joining
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of double-strand break repair via nonhomologous end joining." [GOC:obol]
synonym: "regulation of NHEJ" EXACT [GOC:obol]
is_a: GO:2000779 ! regulation of double-strand break repair
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006303 ! double-strand break repair via nonhomologous end joining
relationship: regulates GO:0006303 ! double-strand break repair via nonhomologous end joining
created_by: yaf
creation_date: 2011-08-24T09:25:39Z

[Term]
id: GO:2001033
name: negative regulation of double-strand break repair via nonhomologous end joining
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of double-strand break repair via nonhomologous end joining." [GOC:obol]
synonym: "negative regulation of NHEJ" EXACT [GOC:obol]
is_a: GO:2000780 ! negative regulation of double-strand break repair
is_a: GO:2001032 ! regulation of double-strand break repair via nonhomologous end joining
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006303 ! double-strand break repair via nonhomologous end joining
relationship: negatively_regulates GO:0006303 ! double-strand break repair via nonhomologous end joining
created_by: yaf
creation_date: 2011-08-24T09:25:46Z

[Term]
id: GO:2001034
name: positive regulation of double-strand break repair via nonhomologous end joining
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of double-strand break repair via nonhomologous end joining." [GOC:obol]
synonym: "positive regulation of NHEJ" EXACT [GOC:obol]
is_a: GO:2000781 ! positive regulation of double-strand break repair
is_a: GO:2001032 ! regulation of double-strand break repair via nonhomologous end joining
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006303 ! double-strand break repair via nonhomologous end joining
relationship: positively_regulates GO:0006303 ! double-strand break repair via nonhomologous end joining
created_by: yaf
creation_date: 2011-08-24T09:25:51Z

[Term]
id: GO:2001035
name: regulation of tongue muscle cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tongue muscle cell differentiation." [GOC:obol]
is_a: GO:1902809 ! regulation of skeletal muscle fiber differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035981 ! tongue muscle cell differentiation
relationship: regulates GO:0035981 ! tongue muscle cell differentiation
created_by: yaf
creation_date: 2011-08-24T11:10:16Z

[Term]
id: GO:2001036
name: negative regulation of tongue muscle cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tongue muscle cell differentiation." [GOC:obol]
is_a: GO:1902810 ! negative regulation of skeletal muscle fiber differentiation
is_a: GO:2001035 ! regulation of tongue muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035981 ! tongue muscle cell differentiation
relationship: negatively_regulates GO:0035981 ! tongue muscle cell differentiation
created_by: yaf
creation_date: 2011-08-24T11:10:20Z

[Term]
id: GO:2001037
name: positive regulation of tongue muscle cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tongue muscle cell differentiation." [GOC:obol]
is_a: GO:1902811 ! positive regulation of skeletal muscle fiber differentiation
is_a: GO:2001035 ! regulation of tongue muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035981 ! tongue muscle cell differentiation
relationship: positively_regulates GO:0035981 ! tongue muscle cell differentiation
created_by: yaf
creation_date: 2011-08-24T11:10:22Z

[Term]
id: GO:2001038
name: regulation of cellular response to drug
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular response to drug." [GOC:obol]
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:2001023 ! regulation of response to drug
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035690 ! cellular response to drug
relationship: regulates GO:0035690 ! cellular response to drug
created_by: yaf
creation_date: 2011-08-27T04:12:19Z

[Term]
id: GO:2001039
name: negative regulation of cellular response to drug
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to drug." [GOC:obol]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:2001024 ! negative regulation of response to drug
is_a: GO:2001038 ! regulation of cellular response to drug
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035690 ! cellular response to drug
relationship: negatively_regulates GO:0035690 ! cellular response to drug
created_by: yaf
creation_date: 2011-08-27T04:12:23Z

[Term]
id: GO:2001040
name: positive regulation of cellular response to drug
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellular response to drug." [GOC:obol]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:2001025 ! positive regulation of response to drug
is_a: GO:2001038 ! regulation of cellular response to drug
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035690 ! cellular response to drug
relationship: positively_regulates GO:0035690 ! cellular response to drug
created_by: yaf
creation_date: 2011-08-27T04:12:25Z

[Term]
id: GO:2001042
name: negative regulation of cell separation after cytokinesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell separation involved in cell cycle cytokinesis." [GOC:mtg_cell_cycle, GOC:obol]
synonym: "negative regulation of cytokinetic cell separation" EXACT []
is_a: GO:0010590 ! regulation of cell separation after cytokinesis
is_a: GO:0051782 ! negative regulation of cell division
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000920 ! cell separation after cytokinesis
relationship: negatively_regulates GO:0000920 ! cell separation after cytokinesis
created_by: mcc
creation_date: 2011-08-30T05:16:55Z

[Term]
id: GO:2001043
name: positive regulation of cell separation after cytokinesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell separation involved after cell cycle cytokinesis." [GOC:mtg_cell_cycle, GOC:obol]
synonym: "positive regulation of cytokinetic cell separation" RELATED []
is_a: GO:0010590 ! regulation of cell separation after cytokinesis
is_a: GO:0051781 ! positive regulation of cell division
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000920 ! cell separation after cytokinesis
relationship: positively_regulates GO:0000920 ! cell separation after cytokinesis
created_by: mcc
creation_date: 2011-08-30T05:16:57Z

[Term]
id: GO:2001044
name: regulation of integrin-mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of integrin-mediated signaling pathway." [GOC:obol]
synonym: "regulation of integrin-mediated signalling pathway" EXACT [GOC:obol]
is_a: GO:0009966 ! regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007229 ! integrin-mediated signaling pathway
relationship: regulates GO:0007229 ! integrin-mediated signaling pathway
created_by: rfoulger
creation_date: 2011-08-31T03:49:11Z

[Term]
id: GO:2001045
name: negative regulation of integrin-mediated signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of integrin-mediated signaling pathway." [GOC:obol]
synonym: "negative regulation of integrin-mediated signalling pathway" EXACT [GOC:obol]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:2001044 ! regulation of integrin-mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007229 ! integrin-mediated signaling pathway
relationship: negatively_regulates GO:0007229 ! integrin-mediated signaling pathway
created_by: rfoulger
creation_date: 2011-08-31T03:49:16Z

[Term]
id: GO:2001046
name: positive regulation of integrin-mediated signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of integrin-mediated signaling pathway." [GOC:obol]
synonym: "positive regulation of integrin-mediated signalling pathway" EXACT [GOC:obol]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:2001044 ! regulation of integrin-mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007229 ! integrin-mediated signaling pathway
relationship: positively_regulates GO:0007229 ! integrin-mediated signaling pathway
created_by: rfoulger
creation_date: 2011-08-31T03:49:19Z

[Term]
id: GO:2001049
name: regulation of tendon cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tendon cell differentiation." [GOC:obol]
synonym: "regulation of muscle attachment cell differentiation" EXACT [GOC:obol]
synonym: "regulation of tenocyte differentiation" RELATED [GOC:obol]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0045595 ! regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035990 ! tendon cell differentiation
relationship: regulates GO:0035990 ! tendon cell differentiation
created_by: yaf
creation_date: 2011-09-01T09:20:32Z

[Term]
id: GO:2001050
name: negative regulation of tendon cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tendon cell differentiation." [GOC:obol]
synonym: "negative regulation of muscle attachment cell differentiation" EXACT [GOC:obol]
synonym: "negative regulation of tenocyte differentiation" RELATED [GOC:obol]
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:2001049 ! regulation of tendon cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035990 ! tendon cell differentiation
relationship: negatively_regulates GO:0035990 ! tendon cell differentiation
created_by: yaf
creation_date: 2011-09-01T09:20:38Z

[Term]
id: GO:2001051
name: positive regulation of tendon cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tendon cell differentiation." [GOC:obol]
synonym: "positive regulation of muscle attachment cell differentiation" EXACT [GOC:obol]
synonym: "positive regulation of tenocyte differentiation" RELATED [GOC:obol]
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:2001049 ! regulation of tendon cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035990 ! tendon cell differentiation
relationship: positively_regulates GO:0035990 ! tendon cell differentiation
created_by: yaf
creation_date: 2011-09-01T09:20:42Z

[Term]
id: GO:2001053
name: regulation of mesenchymal cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesenchymal cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol]
synonym: "regulation of mesenchymal cell apoptosis" NARROW []
is_a: GO:0042981 ! regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097152 ! mesenchymal cell apoptotic process
relationship: regulates GO:0097152 ! mesenchymal cell apoptotic process
created_by: yaf
creation_date: 2011-09-08T02:49:59Z

[Term]
id: GO:2001054
name: negative regulation of mesenchymal cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol]
synonym: "negative regulation of mesenchymal cell apoptosis" NARROW []
is_a: GO:0043066 ! negative regulation of apoptotic process
is_a: GO:2001053 ! regulation of mesenchymal cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097152 ! mesenchymal cell apoptotic process
relationship: negatively_regulates GO:0097152 ! mesenchymal cell apoptotic process
created_by: yaf
creation_date: 2011-09-08T02:50:05Z

[Term]
id: GO:2001055
name: positive regulation of mesenchymal cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mesenchymal cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol]
synonym: "positive regulation of mesenchymal cell apoptosis" NARROW []
is_a: GO:0043065 ! positive regulation of apoptotic process
is_a: GO:2001053 ! regulation of mesenchymal cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097152 ! mesenchymal cell apoptotic process
relationship: positively_regulates GO:0097152 ! mesenchymal cell apoptotic process
created_by: yaf
creation_date: 2011-09-08T02:50:09Z

[Term]
id: GO:2001056
name: positive regulation of cysteine-type endopeptidase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cysteine-type endopeptidase activity." [GOC:obol]
synonym: "positive regulation of lysosomal cysteine-type endopeptidase" RELATED [GOC:obol]
synonym: "positive regulation of thiol endopeptidase activity" EXACT [GOC:obol]
is_a: GO:0010950 ! positive regulation of endopeptidase activity
is_a: GO:2000116 ! regulation of cysteine-type endopeptidase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004197 ! cysteine-type endopeptidase activity
relationship: positively_regulates GO:0004197 ! cysteine-type endopeptidase activity
created_by: pr
creation_date: 2011-09-09T08:53:43Z

[Term]
id: GO:2001057
name: reactive nitrogen species metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a reactive nitrogen species." [GOC:obol]
synonym: "reactive nitrogen species metabolism" EXACT [GOC:obol]
synonym: "RNS metabolic process" EXACT [GOC:obol]
synonym: "RNS metabolism" EXACT [GOC:obol]
is_a: GO:0006807 ! nitrogen compound metabolic process
created_by: jane
creation_date: 2011-09-09T01:29:13Z

[Term]
id: GO:2001058
name: D-tagatose 6-phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a D-tagatose 6-phosphate." [GOC:obol]
synonym: "D-tagatose 6-phosphate metabolism" EXACT [GOC:obol]
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process
created_by: jane
creation_date: 2011-09-09T03:21:28Z

[Term]
id: GO:2001059
name: D-tagatose 6-phosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a D-tagatose 6-phosphate." [GOC:mengo_curators]
synonym: "D-tagatose 6-phosphate catabolism" EXACT [GOC:obol]
xref: UniPathway:UPA00704
is_a: GO:0046434 ! organophosphate catabolic process
is_a: GO:1901136 ! carbohydrate derivative catabolic process
is_a: GO:2001058 ! D-tagatose 6-phosphate metabolic process
created_by: jane
creation_date: 2011-09-09T03:21:33Z

[Term]
id: GO:2001060
name: D-glycero-D-manno-heptose 7-phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a D-glycero-D-manno-heptose 7-phosphate." [GOC:mengo_curators]
synonym: "D-glycero-D-manno-heptose 7-phosphate metabolism" EXACT [GOC:obol]
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process
created_by: jane
creation_date: 2011-09-09T03:29:03Z

[Term]
id: GO:2001061
name: D-glycero-D-manno-heptose 7-phosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a D-glycero-D-manno-heptose 7-phosphate." [GOC:mengo_curators]
synonym: "D-glycero-D-manno-heptose 7-phosphate biosynthesis" EXACT [GOC:obol]
xref: UniPathway:UPA00041
is_a: GO:0090407 ! organophosphate biosynthetic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process
is_a: GO:2001060 ! D-glycero-D-manno-heptose 7-phosphate metabolic process
created_by: jane
creation_date: 2011-09-09T03:29:08Z

[Term]
id: GO:2001062
name: xylan binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with xylan." [GOC:mengo_curators]
is_a: GO:0030247 ! polysaccharide binding
created_by: jane
creation_date: 2011-09-14T10:10:04Z

[Term]
id: GO:2001063
name: glucomannan binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with glucomannan." [GOC:mengo_curators]
is_a: GO:0010297 ! heteropolysaccharide binding
created_by: jane
creation_date: 2011-09-14T10:29:45Z

[Term]
id: GO:2001064
name: cellooligosaccharide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with cellooligosaccharide." [GOC:mengo_curators]
is_a: GO:0070492 ! oligosaccharide binding
created_by: jane
creation_date: 2011-09-14T10:32:19Z

[Term]
id: GO:2001065
name: mannan binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with mannan." [GOC:mengo_curators]
synonym: "mannoglycan binding" RELATED [GOC:obol]
is_a: GO:0030247 ! polysaccharide binding
created_by: jane
creation_date: 2011-09-14T10:49:45Z

[Term]
id: GO:2001066
name: amylopectin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with amylopectin." [GOC:mengo_curators]
is_a: GO:0097367 ! carbohydrate derivative binding
created_by: jane
creation_date: 2011-09-14T11:46:37Z

[Term]
id: GO:2001067
name: pullulan binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with pullulan." [GOC:mengo_curators]
is_a: GO:0030247 ! polysaccharide binding
created_by: jane
creation_date: 2011-09-14T11:50:06Z

[Term]
id: GO:2001068
name: arabinoxylan binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with arabinoxylan." [GOC:mengo_curators]
is_a: GO:2001062 ! xylan binding
created_by: jane
creation_date: 2011-09-14T11:58:38Z

[Term]
id: GO:2001069
name: glycogen binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with glycogen." [GOC:mengo_curators]
synonym: "animal starch binding" RELATED [GOC:obol]
synonym: "liver starch binding" RELATED [GOC:obol]
is_a: GO:0030247 ! polysaccharide binding
created_by: jane
creation_date: 2011-09-14T12:01:06Z

[Term]
id: GO:2001070
name: starch binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with starch." [GOC:mengo_curators]
synonym: "amidon binding" RELATED [GOC:obol]
synonym: "amylum binding" RELATED [GOC:obol]
is_a: GO:0030247 ! polysaccharide binding
created_by: jane
creation_date: 2011-09-14T12:02:50Z

[Term]
id: GO:2001071
name: maltoheptaose binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with maltoheptaose." [GOC:mengo_curators]
is_a: GO:0070492 ! oligosaccharide binding
created_by: jane
creation_date: 2011-09-14T12:04:30Z

[Term]
id: GO:2001072
name: galactomannan binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with galactomannan." [GOC:mengo_curators]
is_a: GO:0010297 ! heteropolysaccharide binding
created_by: jane
creation_date: 2011-09-14T12:12:02Z

[Term]
id: GO:2001073
name: cyclodextrin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with cyclodextrin." [GOC:mengo_curators]
is_a: GO:0070492 ! oligosaccharide binding
created_by: jane
creation_date: 2011-09-14T12:24:30Z

[Term]
id: GO:2001074
name: regulation of metanephric ureteric bud development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of metanephric ureteric bud development." [GOC:obol]
is_a: GO:0061217 ! regulation of mesonephros development
is_a: GO:0072215 ! regulation of metanephros development
is_a: GO:2000027 ! regulation of organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035502 ! metanephric part of ureteric bud development
relationship: regulates GO:0035502 ! metanephric part of ureteric bud development
created_by: yaf
creation_date: 2011-09-14T01:11:06Z

[Term]
id: GO:2001075
name: negative regulation of metanephric ureteric bud development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of metanephric ureteric bud development." [GOC:obol]
is_a: GO:0061218 ! negative regulation of mesonephros development
is_a: GO:0072217 ! negative regulation of metanephros development
is_a: GO:2001074 ! regulation of metanephric ureteric bud development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035502 ! metanephric part of ureteric bud development
relationship: negatively_regulates GO:0035502 ! metanephric part of ureteric bud development
created_by: yaf
creation_date: 2011-09-14T01:11:12Z

[Term]
id: GO:2001076
name: positive regulation of metanephric ureteric bud development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of metanephric ureteric bud development." [GOC:obol]
is_a: GO:0061213 ! positive regulation of mesonephros development
is_a: GO:0072216 ! positive regulation of metanephros development
is_a: GO:2001074 ! regulation of metanephric ureteric bud development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035502 ! metanephric part of ureteric bud development
relationship: positively_regulates GO:0035502 ! metanephric part of ureteric bud development
created_by: yaf
creation_date: 2011-09-14T01:11:15Z

[Term]
id: GO:2001077
name: (1->3),(1->4)-beta-glucan binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with (1->3),(1->4)-beta-glucan." [GOC:mengo_curators]
synonym: "(1,3),(1,4)-beta-glucan binding" EXACT []
synonym: "1->3,1->4-beta-glucan binding" EXACT []
synonym: "beta-(1,3),(1,4)-glucan binding" EXACT []
synonym: "beta-(1->3),(1->4)-glucan binding" EXACT []
synonym: "beta-1,3-1,4-glucan binding" EXACT []
synonym: "beta-1->3,1->4-glucan binding" EXACT []
is_a: GO:0030247 ! polysaccharide binding
created_by: jane
creation_date: 2011-09-15T09:07:33Z

[Term]
id: GO:2001078
name: (1->6)-beta-D-glucan binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with (1->6)-beta-D-glucan." [GOC:mengo_curators]
synonym: "(1,6)-beta-D-glucan binding" EXACT []
synonym: "1,6-beta-D-glucan binding" EXACT []
synonym: "1->6-beta-D-glucan binding" EXACT []
synonym: "beta-(1,6)-D-glucan binding" EXACT []
synonym: "beta-(1->6)-D-glucan binding" EXACT []
synonym: "beta-1,6-D-glucan binding" EXACT []
synonym: "beta-1->6-D-glucan binding" EXACT []
is_a: GO:0030247 ! polysaccharide binding
created_by: jane
creation_date: 2011-09-15T01:12:50Z

[Term]
id: GO:2001079
name: beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc." [GOC:mengo_curators]
is_a: GO:0097367 ! carbohydrate derivative binding
created_by: jane
creation_date: 2011-09-15T01:15:19Z

[Term]
id: GO:2001080
name: chitosan binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with chitosan." [GOC:mengo_curators]
is_a: GO:0070405 ! ammonium ion binding
is_a: GO:0097367 ! carbohydrate derivative binding
created_by: jane
creation_date: 2011-09-15T01:17:32Z

[Term]
id: GO:2001081
name: (1->4)-beta-D-galactan binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with (1->4)-beta-D-galactan." [GOC:mengo_curators]
synonym: "(1,4)-beta-D-galactan binding" EXACT []
is_a: GO:0030247 ! polysaccharide binding
created_by: jane
creation_date: 2011-09-15T01:21:50Z

[Term]
id: GO:2001082
name: inulin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with inulin." [GOC:mengo_curators]
is_a: GO:0030247 ! polysaccharide binding
created_by: jane
creation_date: 2011-09-15T01:23:59Z

[Term]
id: GO:2001083
name: alpha-D-glucan binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with alpha-D-glucan." [GOC:mengo_curators]
is_a: GO:0030247 ! polysaccharide binding
created_by: jane
creation_date: 2011-09-15T01:26:14Z

[Term]
id: GO:2001084
name: L-arabinofuranose binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with L-arabinofuranose." [GOC:mengo_curators]
is_a: GO:0048029 ! monosaccharide binding
created_by: jane
creation_date: 2011-09-15T01:33:53Z

[Term]
id: GO:2001085
name: arabinogalactan binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with arabinogalactan." [GOC:mengo_curators]
is_a: GO:0030247 ! polysaccharide binding
created_by: jane
creation_date: 2011-09-15T01:35:51Z

[Term]
id: GO:2001086
name: laminarabiose transport
namespace: biological_process
def: "The directed movement of a laminarabioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators]
is_a: GO:0015766 ! disaccharide transport
created_by: jane
creation_date: 2011-09-21T12:55:01Z

[Term]
id: GO:2001087
name: sophorose transport
namespace: biological_process
def: "The directed movement of a sophoroseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators]
is_a: GO:0015766 ! disaccharide transport
created_by: jane
creation_date: 2011-09-21T12:58:08Z

[Term]
id: GO:2001088
name: trisaccharide transport
namespace: biological_process
def: "The directed movement of a trisaccharideacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators]
is_a: GO:0015772 ! oligosaccharide transport
created_by: jane
creation_date: 2011-09-21T12:59:46Z

[Term]
id: GO:2001089
name: maltotriose transport
namespace: biological_process
def: "The directed movement of a maltotrioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators]
is_a: GO:2001088 ! trisaccharide transport
created_by: jane
creation_date: 2011-09-21T01:24:26Z

[Term]
id: GO:2001090
name: maltotriulose transport
namespace: biological_process
def: "The directed movement of a maltotriuloseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators]
is_a: GO:2001088 ! trisaccharide transport
created_by: jane
creation_date: 2011-09-21T01:44:15Z

[Term]
id: GO:2001091
name: nigerotriose transport
namespace: biological_process
def: "The directed movement of a nigerotrioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators]
is_a: GO:2001088 ! trisaccharide transport
created_by: jane
creation_date: 2011-09-21T01:51:49Z

[Term]
id: GO:2001092
name: arabinotriose transport
namespace: biological_process
def: "The directed movement of an arabinotrioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators]
is_a: GO:2001088 ! trisaccharide transport
created_by: jane
creation_date: 2011-09-21T01:59:36Z

[Term]
id: GO:2001093
name: galactotriose transport
namespace: biological_process
def: "The directed movement of a galactotrioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators]
is_a: GO:2001088 ! trisaccharide transport
created_by: jane
creation_date: 2011-09-21T02:01:29Z

[Term]
id: GO:2001094
name: xylotriose transport
namespace: biological_process
def: "The directed movement of a xylotrioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators]
is_a: GO:2001088 ! trisaccharide transport
created_by: jane
creation_date: 2011-09-21T02:03:26Z

[Term]
id: GO:2001095
name: mannotriose transport
namespace: biological_process
def: "The directed movement of a mannotrioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators]
is_a: GO:2001088 ! trisaccharide transport
created_by: jane
creation_date: 2011-09-21T02:04:52Z

[Term]
id: GO:2001096
name: cellotriose transport
namespace: biological_process
def: "The directed movement of a cellotrioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators]
is_a: GO:2001088 ! trisaccharide transport
created_by: jane
creation_date: 2011-09-21T02:06:27Z

[Term]
id: GO:2001097
name: laminaritriose transport
namespace: biological_process
def: "The directed movement of a laminaritrioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators]
is_a: GO:2001088 ! trisaccharide transport
created_by: jane
creation_date: 2011-09-21T02:11:36Z

[Term]
id: GO:2001098
name: tetrasaccharide transport
namespace: biological_process
def: "The directed movement of a tetrasaccharideacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators]
is_a: GO:0015772 ! oligosaccharide transport
created_by: jane
creation_date: 2011-09-21T02:12:53Z

[Term]
id: GO:2001099
name: maltotetraose transport
namespace: biological_process
def: "The directed movement of a maltotetraoseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators]
is_a: GO:2001098 ! tetrasaccharide transport
created_by: jane
creation_date: 2011-09-21T02:15:03Z

[Term]
id: GO:2001100
name: pentasaccharide transport
namespace: biological_process
def: "The directed movement of a pentasaccharideacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators]
is_a: GO:0015772 ! oligosaccharide transport
created_by: jane
creation_date: 2011-09-21T02:17:07Z

[Term]
id: GO:2001101
name: maltopentaose transport
namespace: biological_process
def: "The directed movement of a maltopentaoseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators]
is_a: GO:2001100 ! pentasaccharide transport
created_by: jane
creation_date: 2011-09-21T02:18:36Z

[Term]
id: GO:2001102
name: hexasaccharide transport
namespace: biological_process
def: "The directed movement of a hexasaccharideacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators]
is_a: GO:0015772 ! oligosaccharide transport
created_by: jane
creation_date: 2011-09-21T02:20:31Z

[Term]
id: GO:2001103
name: maltohexaose transport
namespace: biological_process
def: "The directed movement of a maltohexaoseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators]
is_a: GO:2001102 ! hexasaccharide transport
created_by: jane
creation_date: 2011-09-21T02:21:40Z

[Term]
id: GO:2001104
name: heptasaccharide transport
namespace: biological_process
def: "The directed movement of a heptasaccharideacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators]
is_a: GO:0015772 ! oligosaccharide transport
created_by: jane
creation_date: 2011-09-21T02:29:58Z

[Term]
id: GO:2001105
name: maltoheptaose transport
namespace: biological_process
def: "The directed movement of a maltoheptaoseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators]
is_a: GO:2001104 ! heptasaccharide transport
created_by: jane
creation_date: 2011-09-21T02:31:22Z

[Term]
id: GO:2001106
name: regulation of Rho guanyl-nucleotide exchange factor activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Rho guanyl-nucleotide exchange factor activity." [GOC:obol]
synonym: "regulation of Rho guanine nucleotide exchange factor" EXACT [GOC:obol]
synonym: "regulation of RhoGEF" EXACT [GOC:obol]
is_a: GO:1905097 ! regulation of guanyl-nucleotide exchange factor activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0005089 ! Rho guanyl-nucleotide exchange factor activity
relationship: regulates GO:0005089 ! Rho guanyl-nucleotide exchange factor activity
created_by: yaf
creation_date: 2011-09-23T10:13:06Z

[Term]
id: GO:2001107
name: negative regulation of Rho guanyl-nucleotide exchange factor activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of Rho guanyl-nucleotide exchange factor activity." [GOC:obol]
synonym: "negative regulation of Rho guanine nucleotide exchange factor" EXACT [GOC:obol]
synonym: "negative regulation of RhoGEF" EXACT [GOC:obol]
is_a: GO:1905098 ! negative regulation of guanyl-nucleotide exchange factor activity
is_a: GO:2001106 ! regulation of Rho guanyl-nucleotide exchange factor activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0005089 ! Rho guanyl-nucleotide exchange factor activity
relationship: negatively_regulates GO:0005089 ! Rho guanyl-nucleotide exchange factor activity
created_by: yaf
creation_date: 2011-09-23T10:13:12Z

[Term]
id: GO:2001108
name: positive regulation of Rho guanyl-nucleotide exchange factor activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of Rho guanyl-nucleotide exchange factor activity." [GOC:obol]
synonym: "positive regulation of Rho guanine nucleotide exchange factor" EXACT [GOC:obol]
synonym: "positive regulation of RhoGEF" EXACT [GOC:obol]
is_a: GO:1905099 ! positive regulation of guanyl-nucleotide exchange factor activity
is_a: GO:2001106 ! regulation of Rho guanyl-nucleotide exchange factor activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0005089 ! Rho guanyl-nucleotide exchange factor activity
relationship: positively_regulates GO:0005089 ! Rho guanyl-nucleotide exchange factor activity
created_by: yaf
creation_date: 2011-09-23T10:13:16Z

[Term]
id: GO:2001109
name: regulation of lens epithelial cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lens epithelial cell proliferation." [GOC:obol]
is_a: GO:0050678 ! regulation of epithelial cell proliferation
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097166 ! lens epithelial cell proliferation
relationship: regulates GO:0097166 ! lens epithelial cell proliferation
created_by: yaf
creation_date: 2011-09-30T02:04:53Z

[Term]
id: GO:2001110
name: negative regulation of lens epithelial cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lens epithelial cell proliferation." [GOC:obol]
is_a: GO:0050680 ! negative regulation of epithelial cell proliferation
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2001109 ! regulation of lens epithelial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097166 ! lens epithelial cell proliferation
relationship: negatively_regulates GO:0097166 ! lens epithelial cell proliferation
created_by: yaf
creation_date: 2011-09-30T02:04:57Z

[Term]
id: GO:2001111
name: positive regulation of lens epithelial cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lens epithelial cell proliferation." [GOC:obol]
is_a: GO:0050679 ! positive regulation of epithelial cell proliferation
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2001109 ! regulation of lens epithelial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097166 ! lens epithelial cell proliferation
relationship: positively_regulates GO:0097166 ! lens epithelial cell proliferation
created_by: yaf
creation_date: 2011-09-30T02:04:59Z

[Term]
id: GO:2001112
name: regulation of cellular response to hepatocyte growth factor stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular response to hepatocyte growth factor stimulus." [GOC:obol]
synonym: "regulation of cellular response to HGF stimulus" EXACT [GOC:obol]
is_a: GO:0090287 ! regulation of cellular response to growth factor stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035729 ! cellular response to hepatocyte growth factor stimulus
relationship: regulates GO:0035729 ! cellular response to hepatocyte growth factor stimulus
created_by: dph
creation_date: 2011-10-05T05:43:18Z

[Term]
id: GO:2001113
name: negative regulation of cellular response to hepatocyte growth factor stimulus
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to hepatocyte growth factor stimulus." [GOC:obol]
synonym: "negative regulation of cellular response to HGF stimulus" EXACT [GOC:obol]
is_a: GO:0090288 ! negative regulation of cellular response to growth factor stimulus
is_a: GO:2001112 ! regulation of cellular response to hepatocyte growth factor stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035729 ! cellular response to hepatocyte growth factor stimulus
relationship: negatively_regulates GO:0035729 ! cellular response to hepatocyte growth factor stimulus
created_by: dph
creation_date: 2011-10-05T05:43:23Z

[Term]
id: GO:2001114
name: positive regulation of cellular response to hepatocyte growth factor stimulus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellular response to hepatocyte growth factor stimulus." [GOC:obol]
synonym: "positive regulation of cellular response to HGF stimulus" EXACT [GOC:obol]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:2001112 ! regulation of cellular response to hepatocyte growth factor stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035729 ! cellular response to hepatocyte growth factor stimulus
relationship: positively_regulates GO:0035729 ! cellular response to hepatocyte growth factor stimulus
created_by: dph
creation_date: 2011-10-05T05:43:26Z

[Term]
id: GO:2001115
name: methanopterin-containing compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a methanopterin." [GOC:mengo_curators]
synonym: "methanopterin metabolism" EXACT [GOC:obol]
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:0042558 ! pteridine-containing compound metabolic process
created_by: jane
creation_date: 2011-10-11T11:54:56Z

[Term]
id: GO:2001116
name: methanopterin-containing compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a methanopterin." [GOC:mengo_curators]
synonym: "methanopterin biosynthesis" EXACT [GOC:obol]
is_a: GO:0042559 ! pteridine-containing compound biosynthetic process
is_a: GO:0090407 ! organophosphate biosynthetic process
is_a: GO:2001115 ! methanopterin-containing compound metabolic process
created_by: jane
creation_date: 2011-10-11T11:55:00Z

[Term]
id: GO:2001117
name: tetrahydromethanopterin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a tetrahydromethanopterin." [GOC:mengo_curators]
synonym: "tetrahydromethanopterin metabolism" EXACT [GOC:obol]
is_a: GO:2001115 ! methanopterin-containing compound metabolic process
created_by: jane
creation_date: 2011-10-11T12:13:15Z

[Term]
id: GO:2001118
name: tetrahydromethanopterin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a tetrahydromethanopterin." [GOC:mengo_curators]
synonym: "tetrahydromethanopterin biosynthesis" EXACT [GOC:obol]
is_a: GO:2001116 ! methanopterin-containing compound biosynthetic process
is_a: GO:2001117 ! tetrahydromethanopterin metabolic process
created_by: jane
creation_date: 2011-10-11T12:13:19Z

[Term]
id: GO:2001119
name: methanofuran metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a methanofuran." [GOC:mengo_curators]
synonym: "methanofuran metabolism" EXACT [GOC:obol]
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
created_by: jane
creation_date: 2011-10-11T12:34:08Z

[Term]
id: GO:2001120
name: methanofuran biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a methanofuran." [GOC:mengo_curators]
synonym: "methanofuran biosynthesis" EXACT [GOC:obol]
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:2001119 ! methanofuran metabolic process
created_by: jane
creation_date: 2011-10-11T12:34:12Z

[Term]
id: GO:2001121
name: coenzyme gamma-F420-2 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a coenzyme gamma-F420-2." [GOC:mengo_curators]
synonym: "coenzyme gamma-F420-2 biosynthesis" EXACT [GOC:obol]
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0052649 ! coenzyme gamma-F420-2 metabolic process
is_a: GO:0072351 ! tricarboxylic acid biosynthetic process
is_a: GO:0090407 ! organophosphate biosynthetic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process
created_by: jane
creation_date: 2011-10-11T02:38:14Z

[Term]
id: GO:2001122
name: maltoheptaose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a maltoheptaose." [GOC:mengo_curators]
synonym: "maltoheptaose metabolism" EXACT [GOC:obol]
is_a: GO:0009311 ! oligosaccharide metabolic process
created_by: jane
creation_date: 2011-10-11T02:41:26Z

[Term]
id: GO:2001123
name: maltoheptaose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a maltoheptaose." [GOC:mengo_curators]
synonym: "maltoheptaose catabolism" EXACT [GOC:obol]
is_a: GO:0009313 ! oligosaccharide catabolic process
is_a: GO:2001122 ! maltoheptaose metabolic process
created_by: jane
creation_date: 2011-10-11T02:41:29Z

[Term]
id: GO:2001124
name: regulation of translational frameshifting
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of translational frameshifting." [GOC:obol]
is_a: GO:0006448 ! regulation of translational elongation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006452 ! translational frameshifting
relationship: regulates GO:0006452 ! translational frameshifting
created_by: dph
creation_date: 2011-10-12T05:52:22Z

[Term]
id: GO:2001125
name: negative regulation of translational frameshifting
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of translational frameshifting." [GOC:obol]
is_a: GO:0045900 ! negative regulation of translational elongation
is_a: GO:2001124 ! regulation of translational frameshifting
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006452 ! translational frameshifting
relationship: negatively_regulates GO:0006452 ! translational frameshifting
created_by: dph
creation_date: 2011-10-12T05:52:27Z

[Term]
id: GO:2001126
name: positive regulation of translational frameshifting
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of translational frameshifting." [GOC:obol]
is_a: GO:0045901 ! positive regulation of translational elongation
is_a: GO:2001124 ! regulation of translational frameshifting
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006452 ! translational frameshifting
relationship: positively_regulates GO:0006452 ! translational frameshifting
created_by: dph
creation_date: 2011-10-12T05:52:30Z

[Term]
id: GO:2001127
name: methane biosynthetic process from formic acid
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a methane from a formic acid." [GOC:mengo_curators]
is_a: GO:0015942 ! formate metabolic process
is_a: GO:0015948 ! methanogenesis
created_by: jane
creation_date: 2011-10-13T09:54:03Z

[Term]
id: GO:2001128
name: methane biosynthetic process from methylamine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a methane from a methylamine." [GOC:mengo_curators]
is_a: GO:0015948 ! methanogenesis
is_a: GO:0030416 ! methylamine metabolic process
created_by: jane
creation_date: 2011-10-13T10:23:25Z

[Term]
id: GO:2001129
name: methane biosynthetic process from dimethylamine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a methane from a dimethylamine." [GOC:mengo_curators]
is_a: GO:0009308 ! amine metabolic process
is_a: GO:0015948 ! methanogenesis
is_a: GO:0097164 ! ammonium ion metabolic process
created_by: jane
creation_date: 2011-10-13T10:26:13Z

[Term]
id: GO:2001130
name: methane biosynthetic process from trimethylamine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a methane from a trimethylamine." [GOC:mengo_curators]
is_a: GO:0009308 ! amine metabolic process
is_a: GO:0015948 ! methanogenesis
is_a: GO:0097164 ! ammonium ion metabolic process
created_by: jane
creation_date: 2011-10-13T10:28:03Z

[Term]
id: GO:2001131
name: methane biosynthetic process from dimethyl sulfide
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a methane from a dimethyl sulfide." [GOC:mengo_curators]
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0015948 ! methanogenesis
created_by: jane
creation_date: 2011-10-13T10:44:31Z

[Term]
id: GO:2001132
name: methane biosynthetic process from 3-(methylthio)propionic acid
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a methane from a 3-(methylthio)propionic acid." [GOC:mengo_curators]
is_a: GO:0006631 ! fatty acid metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0015948 ! methanogenesis
created_by: jane
creation_date: 2011-10-13T12:19:33Z

[Term]
id: GO:2001133
name: methane biosynthetic process from methanethiol
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a methane from a methanethiol." [GOC:mengo_curators]
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0015948 ! methanogenesis
created_by: jane
creation_date: 2011-10-13T12:32:57Z

[Term]
id: GO:2001134
name: methane biosynthetic process from carbon monoxide
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a methane from a carbon monoxide." [GOC:mengo_curators]
is_a: GO:0015948 ! methanogenesis
created_by: jane
creation_date: 2011-10-13T12:36:20Z

[Term]
id: GO:2001135
name: regulation of endocytic recycling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endocytic recycling." [GOC:obol]
synonym: "regulation of retrograde transport of endocytic vesicles" RELATED [GOC:obol]
is_a: GO:0060627 ! regulation of vesicle-mediated transport
is_a: GO:1903335 ! regulation of vacuolar transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032456 ! endocytic recycling
relationship: regulates GO:0032456 ! endocytic recycling
created_by: kmv
creation_date: 2011-10-14T03:34:36Z

[Term]
id: GO:2001136
name: negative regulation of endocytic recycling
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of endocytic recycling." [GOC:obol]
synonym: "negative regulation of retrograde transport of endocytic vesicles" RELATED [GOC:obol]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:1903336 ! negative regulation of vacuolar transport
is_a: GO:2001135 ! regulation of endocytic recycling
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032456 ! endocytic recycling
relationship: negatively_regulates GO:0032456 ! endocytic recycling
created_by: kmv
creation_date: 2011-10-14T03:34:43Z

[Term]
id: GO:2001137
name: positive regulation of endocytic recycling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endocytic recycling." [GOC:obol]
synonym: "positive regulation of retrograde transport of endocytic vesicles" RELATED [GOC:obol]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:1903337 ! positive regulation of vacuolar transport
is_a: GO:2001135 ! regulation of endocytic recycling
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032456 ! endocytic recycling
relationship: positively_regulates GO:0032456 ! endocytic recycling
created_by: kmv
creation_date: 2011-10-14T03:34:49Z

[Term]
id: GO:2001138
name: regulation of phospholipid transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phospholipid transport." [GOC:obol]
is_a: GO:0032368 ! regulation of lipid transport
is_a: GO:0044070 ! regulation of anion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0015914 ! phospholipid transport
relationship: regulates GO:0015914 ! phospholipid transport
created_by: kmv
creation_date: 2011-10-14T06:16:06Z

[Term]
id: GO:2001139
name: negative regulation of phospholipid transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of phospholipid transport." [GOC:obol]
is_a: GO:0032369 ! negative regulation of lipid transport
is_a: GO:1903792 ! negative regulation of anion transport
is_a: GO:2001138 ! regulation of phospholipid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0015914 ! phospholipid transport
relationship: negatively_regulates GO:0015914 ! phospholipid transport
created_by: kmv
creation_date: 2011-10-14T06:16:11Z

[Term]
id: GO:2001140
name: positive regulation of phospholipid transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phospholipid transport." [GOC:obol]
is_a: GO:0032370 ! positive regulation of lipid transport
is_a: GO:1903793 ! positive regulation of anion transport
is_a: GO:2001138 ! regulation of phospholipid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0015914 ! phospholipid transport
relationship: positively_regulates GO:0015914 ! phospholipid transport
created_by: kmv
creation_date: 2011-10-14T06:16:14Z

[Term]
id: GO:2001141
name: regulation of RNA biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of RNA biosynthetic process." [GOC:dph]
synonym: "regulation of RNA anabolism" EXACT [GOC:obol]
synonym: "regulation of RNA biosynthesis" EXACT [GOC:obol]
synonym: "regulation of RNA formation" EXACT [GOC:obol]
synonym: "regulation of RNA synthesis" EXACT [GOC:obol]
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0051252 ! regulation of RNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032774 ! RNA biosynthetic process
relationship: regulates GO:0032774 ! RNA biosynthetic process
created_by: dph
creation_date: 2011-10-17T11:36:25Z

[Term]
id: GO:2001142
name: nicotinate transport
namespace: biological_process
def: "The directed movement of a nicotinateacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:obol]
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0071705 ! nitrogen compound transport
created_by: tanyaberardini
creation_date: 2011-10-18T05:09:50Z

[Term]
id: GO:2001143
name: N-methylnicotinate transport
namespace: biological_process
def: "The directed movement of a N-methylnicotinateacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:obol]
is_a: GO:0015695 ! organic cation transport
is_a: GO:0015697 ! quaternary ammonium group transport
created_by: tanyaberardini
creation_date: 2011-10-18T05:16:08Z

[Term]
id: GO:2001144
name: regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity." [GOC:obol]
is_a: GO:0010921 ! regulation of phosphatase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034485 ! phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
relationship: regulates GO:0034485 ! phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
created_by: yaf
creation_date: 2011-10-19T10:41:25Z

[Term]
id: GO:2001145
name: negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity." [GOC:obol]
is_a: GO:0010923 ! negative regulation of phosphatase activity
is_a: GO:2001144 ! regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034485 ! phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
relationship: negatively_regulates GO:0034485 ! phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
created_by: yaf
creation_date: 2011-10-19T10:41:28Z

[Term]
id: GO:2001146
name: positive regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity." [GOC:obol]
is_a: GO:0010922 ! positive regulation of phosphatase activity
is_a: GO:2001144 ! regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034485 ! phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
relationship: positively_regulates GO:0034485 ! phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
created_by: yaf
creation_date: 2011-10-19T10:41:30Z

[Term]
id: GO:2001147
name: camalexin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with camalexin." [GOC:obol]
synonym: "3-(1,3-thiazol-2-yl)-1H-indole binding" EXACT [GOC:obol]
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding
is_a: GO:1901681 ! sulfur compound binding
created_by: tanyaberardini
creation_date: 2011-10-19T10:54:19Z

[Term]
id: GO:2001148
name: regulation of dipeptide transmembrane transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dipeptide transmembrane transport." [GOC:obol]
synonym: "regulation of dipeptide membrane transport" EXACT []
is_a: GO:0034762 ! regulation of transmembrane transport
is_a: GO:0090089 ! regulation of dipeptide transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035442 ! dipeptide transmembrane transport
relationship: regulates GO:0035442 ! dipeptide transmembrane transport
created_by: kmv
creation_date: 2011-10-21T04:34:20Z

[Term]
id: GO:2001149
name: negative regulation of dipeptide transmembrane transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of dipeptide transmembrane transport." [GOC:obol]
synonym: "negative regulation of dipeptide membrane transport" EXACT []
is_a: GO:0034763 ! negative regulation of transmembrane transport
is_a: GO:2000879 ! negative regulation of dipeptide transport
is_a: GO:2001148 ! regulation of dipeptide transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035442 ! dipeptide transmembrane transport
relationship: negatively_regulates GO:0035442 ! dipeptide transmembrane transport
created_by: kmv
creation_date: 2011-10-21T06:09:59Z

[Term]
id: GO:2001150
name: positive regulation of dipeptide transmembrane transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of dipeptide transmembrane transport." [GOC:obol]
synonym: "positive regulation of dipeptide membrane transport" EXACT []
is_a: GO:0034764 ! positive regulation of transmembrane transport
is_a: GO:2000880 ! positive regulation of dipeptide transport
is_a: GO:2001148 ! regulation of dipeptide transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035442 ! dipeptide transmembrane transport
relationship: positively_regulates GO:0035442 ! dipeptide transmembrane transport
created_by: kmv
creation_date: 2011-10-21T06:10:03Z

[Term]
id: GO:2001151
name: regulation of renal water transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of renal water transport." [GOC:obol]
is_a: GO:0032844 ! regulation of homeostatic process
is_a: GO:0050878 ! regulation of body fluid levels
is_a: GO:0051049 ! regulation of transport
is_a: GO:0098801 ! regulation of renal system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003097 ! renal water transport
relationship: regulates GO:0003097 ! renal water transport
created_by: yaf
creation_date: 2011-10-24T11:37:51Z

[Term]
id: GO:2001152
name: negative regulation of renal water transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of renal water transport." [GOC:obol]
is_a: GO:0032845 ! negative regulation of homeostatic process
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2001151 ! regulation of renal water transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003097 ! renal water transport
relationship: negatively_regulates GO:0003097 ! renal water transport
created_by: yaf
creation_date: 2011-10-24T11:37:57Z

[Term]
id: GO:2001153
name: positive regulation of renal water transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of renal water transport." [GOC:obol]
is_a: GO:0032846 ! positive regulation of homeostatic process
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2001151 ! regulation of renal water transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003097 ! renal water transport
relationship: positively_regulates GO:0003097 ! renal water transport
created_by: yaf
creation_date: 2011-10-24T11:38:01Z

[Term]
id: GO:2001154
name: regulation of glycolytic fermentation to ethanol
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glucose catabolic process to ethanol." [GOC:obol]
synonym: "regulation of ethanol fermentation" EXACT [GOC:obol]
synonym: "regulation of glucose fermentation to ethanol" EXACT [GOC:obol]
is_a: GO:0010906 ! regulation of glucose metabolic process
is_a: GO:0030811 ! regulation of nucleotide catabolic process
is_a: GO:0043465 ! regulation of fermentation
is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process
is_a: GO:1902688 ! regulation of NAD metabolic process
is_a: GO:1903578 ! regulation of ATP metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019655 ! glycolytic fermentation to ethanol
relationship: regulates GO:0019655 ! glycolytic fermentation to ethanol
created_by: mcc
creation_date: 2011-10-27T02:39:00Z

[Term]
id: GO:2001155
name: negative regulation of glycolytic fermentation to ethanol
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glucose catabolic process to ethanol." [GOC:obol]
synonym: "negative regulation of ethanol fermentation" EXACT [GOC:obol]
synonym: "negative regulation of glucose fermentation to ethanol" EXACT [GOC:obol]
is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process
is_a: GO:0030812 ! negative regulation of nucleotide catabolic process
is_a: GO:1901003 ! negative regulation of fermentation
is_a: GO:1902689 ! negative regulation of NAD metabolic process
is_a: GO:1903579 ! negative regulation of ATP metabolic process
is_a: GO:2001154 ! regulation of glycolytic fermentation to ethanol
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019655 ! glycolytic fermentation to ethanol
relationship: negatively_regulates GO:0019655 ! glycolytic fermentation to ethanol
created_by: mcc
creation_date: 2011-10-27T02:39:05Z

[Term]
id: GO:2001156
name: regulation of proline catabolic process to glutamate
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of proline catabolic process to glutamate." [GOC:obol]
synonym: "regulation of proline breakdown to glutamate" EXACT [GOC:obol]
synonym: "regulation of proline degradation to glutamate" EXACT [GOC:obol]
synonym: "regulation of proline oxidation" RELATED [GOC:obol]
is_a: GO:0033241 ! regulation of cellular amine catabolic process
is_a: GO:2000211 ! regulation of glutamate metabolic process
is_a: GO:2000214 ! regulation of proline metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010133 ! proline catabolic process to glutamate
relationship: regulates GO:0010133 ! proline catabolic process to glutamate
created_by: mcc
creation_date: 2011-10-25T08:54:37Z

[Term]
id: GO:2001157
name: negative regulation of proline catabolic process to glutamate
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of proline catabolic process to glutamate." [GOC:obol]
synonym: "negative regulation of proline breakdown to glutamate" EXACT [GOC:obol]
synonym: "negative regulation of proline degradation to glutamate" EXACT [GOC:obol]
synonym: "negative regulation of proline oxidation" RELATED [GOC:obol]
is_a: GO:0033242 ! negative regulation of cellular amine catabolic process
is_a: GO:2000212 ! negative regulation of glutamate metabolic process
is_a: GO:2000215 ! negative regulation of proline metabolic process
is_a: GO:2001156 ! regulation of proline catabolic process to glutamate
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010133 ! proline catabolic process to glutamate
relationship: negatively_regulates GO:0010133 ! proline catabolic process to glutamate
created_by: mcc
creation_date: 2011-10-25T08:54:43Z

[Term]
id: GO:2001158
name: positive regulation of proline catabolic process to glutamate
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of proline catabolic process to glutamate." [GOC:obol]
synonym: "positive regulation of proline breakdown to glutamate" EXACT [GOC:obol]
synonym: "positive regulation of proline degradation to glutamate" EXACT [GOC:obol]
synonym: "positive regulation of proline oxidation" RELATED [GOC:obol]
is_a: GO:0033243 ! positive regulation of cellular amine catabolic process
is_a: GO:2000213 ! positive regulation of glutamate metabolic process
is_a: GO:2000216 ! positive regulation of proline metabolic process
is_a: GO:2001156 ! regulation of proline catabolic process to glutamate
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010133 ! proline catabolic process to glutamate
relationship: positively_regulates GO:0010133 ! proline catabolic process to glutamate
created_by: mcc
creation_date: 2011-10-25T08:54:50Z

[Term]
id: GO:2001159
name: regulation of CVT pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of CVT pathway." [GOC:obol]
synonym: "regulation of cytoplasm to vacuole targeting" EXACT [GOC:obol]
synonym: "regulation of cytoplasm-to-vacuole targeting" EXACT [GOC:obol]
is_a: GO:1903335 ! regulation of vacuolar transport
is_a: GO:1903533 ! regulation of protein targeting
is_a: GO:1903649 ! regulation of cytoplasmic transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032258 ! CVT pathway
relationship: regulates GO:0032258 ! CVT pathway
created_by: jp
creation_date: 2011-10-25T10:22:24Z

[Term]
id: GO:2001160
name: regulation of histone H3-K79 methylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of histone H3-K79 methylation." [PMID:12876294]
synonym: "regulation of histone H3 K79 methylation" EXACT [GOC:obol]
synonym: "regulation of histone H3K79me" EXACT [GOC:obol]
synonym: "regulation of histone lysine H3 K79 methylation" EXACT [GOC:obol]
is_a: GO:0031060 ! regulation of histone methylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034729 ! histone H3-K79 methylation
relationship: regulates GO:0034729 ! histone H3-K79 methylation
created_by: se
creation_date: 2011-10-25T10:27:00Z

[Term]
id: GO:2001161
name: negative regulation of histone H3-K79 methylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K79 methylation." [PMID:12876294]
synonym: "negative regulation of histone H3 K79 methylation" EXACT [GOC:obol]
synonym: "negative regulation of histone H3K79me" EXACT [GOC:obol]
synonym: "negative regulation of histone lysine H3 K79 methylation" EXACT [GOC:obol]
is_a: GO:0031061 ! negative regulation of histone methylation
is_a: GO:2001160 ! regulation of histone H3-K79 methylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034729 ! histone H3-K79 methylation
relationship: negatively_regulates GO:0034729 ! histone H3-K79 methylation
created_by: se
creation_date: 2011-10-25T10:27:05Z

[Term]
id: GO:2001162
name: positive regulation of histone H3-K79 methylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of histone H3-K79 methylation." [PMID:12876294]
synonym: "positive regulation of histone H3 K79 methylation" EXACT [GOC:obol]
synonym: "positive regulation of histone H3K79me" EXACT [GOC:obol]
synonym: "positive regulation of histone lysine H3 K79 methylation" EXACT [GOC:obol]
is_a: GO:0031062 ! positive regulation of histone methylation
is_a: GO:2001160 ! regulation of histone H3-K79 methylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034729 ! histone H3-K79 methylation
relationship: positively_regulates GO:0034729 ! histone H3-K79 methylation
created_by: se
creation_date: 2011-10-25T10:27:10Z

[Term]
id: GO:2001163
name: regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues." [PMID:15149594]
is_a: GO:1901407 ! regulation of phosphorylation of RNA polymerase II C-terminal domain
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071619 ! phosphorylation of RNA polymerase II C-terminal domain serine 2 residues
relationship: regulates GO:0071619 ! phosphorylation of RNA polymerase II C-terminal domain serine 2 residues
created_by: se
creation_date: 2011-10-25T10:30:59Z

[Term]
id: GO:2001164
name: negative regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues." [PMID:15149594]
is_a: GO:1901408 ! negative regulation of phosphorylation of RNA polymerase II C-terminal domain
is_a: GO:2001163 ! regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071619 ! phosphorylation of RNA polymerase II C-terminal domain serine 2 residues
relationship: negatively_regulates GO:0071619 ! phosphorylation of RNA polymerase II C-terminal domain serine 2 residues
created_by: se
creation_date: 2011-10-25T10:31:03Z

[Term]
id: GO:2001165
name: positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues." [PMID:15149594]
is_a: GO:1901409 ! positive regulation of phosphorylation of RNA polymerase II C-terminal domain
is_a: GO:2001163 ! regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071619 ! phosphorylation of RNA polymerase II C-terminal domain serine 2 residues
relationship: positively_regulates GO:0071619 ! phosphorylation of RNA polymerase II C-terminal domain serine 2 residues
created_by: se
creation_date: 2011-10-25T10:31:07Z

[Term]
id: GO:2001166
name: regulation of histone H2B ubiquitination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of histone H2B ubiquitination." [PMID:12876293]
is_a: GO:0033182 ! regulation of histone ubiquitination
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0033523 ! histone H2B ubiquitination
relationship: regulates GO:0033523 ! histone H2B ubiquitination
created_by: se
creation_date: 2011-10-25T10:49:51Z

[Term]
id: GO:2001167
name: negative regulation of histone H2B ubiquitination
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone H2B ubiquitination." [PMID:12876293]
is_a: GO:0033183 ! negative regulation of histone ubiquitination
is_a: GO:2001166 ! regulation of histone H2B ubiquitination
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0033523 ! histone H2B ubiquitination
relationship: negatively_regulates GO:0033523 ! histone H2B ubiquitination
created_by: se
creation_date: 2011-10-25T10:49:56Z

[Term]
id: GO:2001168
name: positive regulation of histone H2B ubiquitination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of histone H2B ubiquitination." [PMID:12876293]
is_a: GO:0033184 ! positive regulation of histone ubiquitination
is_a: GO:2001166 ! regulation of histone H2B ubiquitination
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0033523 ! histone H2B ubiquitination
relationship: positively_regulates GO:0033523 ! histone H2B ubiquitination
created_by: se
creation_date: 2011-10-25T10:50:01Z

[Term]
id: GO:2001169
name: regulation of ATP biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ATP biosynthetic process." [GOC:obol]
synonym: "regulation of ATP anabolism" EXACT [GOC:obol]
synonym: "regulation of ATP biosynthesis" EXACT [GOC:obol]
synonym: "regulation of ATP formation" EXACT [GOC:obol]
synonym: "regulation of ATP regeneration" RELATED [GOC:obol]
synonym: "regulation of ATP synthesis" EXACT [GOC:obol]
is_a: GO:1900371 ! regulation of purine nucleotide biosynthetic process
is_a: GO:1903578 ! regulation of ATP metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006754 ! ATP biosynthetic process
relationship: regulates GO:0006754 ! ATP biosynthetic process
created_by: kmv
creation_date: 2011-10-26T03:18:03Z

[Term]
id: GO:2001170
name: negative regulation of ATP biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ATP biosynthetic process." [GOC:obol]
synonym: "negative regulation of ATP anabolism" EXACT [GOC:obol]
synonym: "negative regulation of ATP biosynthesis" EXACT [GOC:obol]
synonym: "negative regulation of ATP formation" EXACT [GOC:obol]
synonym: "negative regulation of ATP regeneration" RELATED [GOC:obol]
synonym: "negative regulation of ATP synthesis" EXACT [GOC:obol]
is_a: GO:1900372 ! negative regulation of purine nucleotide biosynthetic process
is_a: GO:1903579 ! negative regulation of ATP metabolic process
is_a: GO:2001169 ! regulation of ATP biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006754 ! ATP biosynthetic process
relationship: negatively_regulates GO:0006754 ! ATP biosynthetic process
created_by: kmv
creation_date: 2011-10-26T03:18:13Z

[Term]
id: GO:2001171
name: positive regulation of ATP biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ATP biosynthetic process." [GOC:obol]
synonym: "positive regulation of ATP anabolism" EXACT [GOC:obol]
synonym: "positive regulation of ATP biosynthesis" EXACT [GOC:obol]
synonym: "positive regulation of ATP formation" EXACT [GOC:obol]
synonym: "positive regulation of ATP regeneration" RELATED [GOC:obol]
synonym: "positive regulation of ATP synthesis" EXACT [GOC:obol]
is_a: GO:1900373 ! positive regulation of purine nucleotide biosynthetic process
is_a: GO:1903580 ! positive regulation of ATP metabolic process
is_a: GO:2001169 ! regulation of ATP biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006754 ! ATP biosynthetic process
relationship: positively_regulates GO:0006754 ! ATP biosynthetic process
created_by: kmv
creation_date: 2011-10-26T03:18:26Z

[Term]
id: GO:2001172
name: positive regulation of glycolytic fermentation to ethanol
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glucose catabolic process to ethanol." [GOC:obol]
synonym: "positive regulation of ethanol fermentation" EXACT [GOC:obol]
synonym: "positive regulation of glucose fermentation to ethanol" EXACT [GOC:obol]
is_a: GO:0010907 ! positive regulation of glucose metabolic process
is_a: GO:0030813 ! positive regulation of nucleotide catabolic process
is_a: GO:1902690 ! positive regulation of NAD metabolic process
is_a: GO:1903580 ! positive regulation of ATP metabolic process
is_a: GO:2001154 ! regulation of glycolytic fermentation to ethanol
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0019655 ! glycolytic fermentation to ethanol
relationship: positively_regulates GO:0019655 ! glycolytic fermentation to ethanol
created_by: mcc
creation_date: 2011-10-27T02:39:09Z

[Term]
id: GO:2001173
name: regulation of histone H2B conserved C-terminal lysine ubiquitination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of histone H2B conserved C-terminal lysine ubiquitination." [PMID:17576814]
synonym: "regulation of budding yeast H2B K123 ubiquitination" RELATED [GOC:obol]
synonym: "regulation of fission yeast H2B K119 ubiquitination" RELATED [GOC:obol]
synonym: "regulation of mammalian H2B K120 ubiquitination" RELATED [GOC:obol]
is_a: GO:2001166 ! regulation of histone H2B ubiquitination
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071894 ! histone H2B conserved C-terminal lysine ubiquitination
relationship: regulates GO:0071894 ! histone H2B conserved C-terminal lysine ubiquitination
created_by: se
creation_date: 2011-10-29T06:28:47Z

[Term]
id: GO:2001174
name: negative regulation of histone H2B conserved C-terminal lysine ubiquitination
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone H2B conserved C-terminal lysine ubiquitination." [PMID:17576814]
synonym: "negative regulation of budding yeast H2B K123 ubiquitination" RELATED [GOC:obol]
synonym: "negative regulation of fission yeast H2B K119 ubiquitination" RELATED [GOC:obol]
synonym: "negative regulation of mammalian H2B K120 ubiquitination" RELATED [GOC:obol]
is_a: GO:2001167 ! negative regulation of histone H2B ubiquitination
is_a: GO:2001173 ! regulation of histone H2B conserved C-terminal lysine ubiquitination
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071894 ! histone H2B conserved C-terminal lysine ubiquitination
relationship: negatively_regulates GO:0071894 ! histone H2B conserved C-terminal lysine ubiquitination
created_by: se
creation_date: 2011-10-29T06:28:53Z

[Term]
id: GO:2001175
name: positive regulation of histone H2B conserved C-terminal lysine ubiquitination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of histone H2B conserved C-terminal lysine ubiquitination." [PMID:17576814]
synonym: "positive regulation of budding yeast H2B K123 ubiquitination" RELATED [GOC:obol]
synonym: "positive regulation of fission yeast H2B K119 ubiquitination" RELATED [GOC:obol]
synonym: "positive regulation of mammalian H2B K120 ubiquitination" RELATED [GOC:obol]
is_a: GO:2001168 ! positive regulation of histone H2B ubiquitination
is_a: GO:2001173 ! regulation of histone H2B conserved C-terminal lysine ubiquitination
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071894 ! histone H2B conserved C-terminal lysine ubiquitination
relationship: positively_regulates GO:0071894 ! histone H2B conserved C-terminal lysine ubiquitination
created_by: se
creation_date: 2011-10-29T06:28:59Z

[Term]
id: GO:2001176
name: regulation of mediator complex assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mediator complex assembly." [GOC:obol]
is_a: GO:0043254 ! regulation of protein complex assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0036034 ! mediator complex assembly
relationship: regulates GO:0036034 ! mediator complex assembly
created_by: yaf
creation_date: 2011-11-02T11:22:18Z

[Term]
id: GO:2001177
name: negative regulation of mediator complex assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mediator complex assembly." [GOC:obol]
is_a: GO:0031333 ! negative regulation of protein complex assembly
is_a: GO:2001176 ! regulation of mediator complex assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0036034 ! mediator complex assembly
relationship: negatively_regulates GO:0036034 ! mediator complex assembly
created_by: yaf
creation_date: 2011-11-02T11:22:23Z

[Term]
id: GO:2001178
name: positive regulation of mediator complex assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mediator complex assembly." [GOC:obol]
is_a: GO:0031334 ! positive regulation of protein complex assembly
is_a: GO:2001176 ! regulation of mediator complex assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0036034 ! mediator complex assembly
relationship: positively_regulates GO:0036034 ! mediator complex assembly
created_by: yaf
creation_date: 2011-11-02T11:22:27Z

[Term]
id: GO:2001179
name: regulation of interleukin-10 secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of interleukin-10 secretion." [GOC:obol]
synonym: "regulation of IL-10 secretion" EXACT [GOC:obol]
is_a: GO:0032653 ! regulation of interleukin-10 production
is_a: GO:0050707 ! regulation of cytokine secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072608 ! interleukin-10 secretion
relationship: regulates GO:0072608 ! interleukin-10 secretion
created_by: yaf
creation_date: 2011-11-03T10:53:48Z

[Term]
id: GO:2001180
name: negative regulation of interleukin-10 secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-10 secretion." [GOC:obol]
synonym: "negative regulation of IL-10 secretion" EXACT [GOC:obol]
is_a: GO:0032693 ! negative regulation of interleukin-10 production
is_a: GO:0050710 ! negative regulation of cytokine secretion
is_a: GO:2001179 ! regulation of interleukin-10 secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072608 ! interleukin-10 secretion
relationship: negatively_regulates GO:0072608 ! interleukin-10 secretion
created_by: yaf
creation_date: 2011-11-03T10:53:54Z

[Term]
id: GO:2001181
name: positive regulation of interleukin-10 secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of interleukin-10 secretion." [GOC:obol]
synonym: "positive regulation of IL-10 secretion" EXACT [GOC:obol]
is_a: GO:0032733 ! positive regulation of interleukin-10 production
is_a: GO:0050715 ! positive regulation of cytokine secretion
is_a: GO:2001179 ! regulation of interleukin-10 secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072608 ! interleukin-10 secretion
relationship: positively_regulates GO:0072608 ! interleukin-10 secretion
created_by: yaf
creation_date: 2011-11-03T10:53:58Z

[Term]
id: GO:2001182
name: regulation of interleukin-12 secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of interleukin-12 secretion." [GOC:obol]
synonym: "regulation of CLMF secretion" RELATED [GOC:obol]
synonym: "regulation of IL-12 secretion" EXACT [GOC:obol]
synonym: "regulation of IL12 secretion" EXACT [GOC:obol]
synonym: "regulation of interleukin-12 complex secretion" EXACT [GOC:obol]
synonym: "regulation of NKSF secretion" RELATED [GOC:obol]
is_a: GO:0032655 ! regulation of interleukin-12 production
is_a: GO:0050707 ! regulation of cytokine secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072610 ! interleukin-12 secretion
relationship: regulates GO:0072610 ! interleukin-12 secretion
created_by: yaf
creation_date: 2011-11-03T01:10:29Z

[Term]
id: GO:2001183
name: negative regulation of interleukin-12 secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-12 secretion." [GOC:obol]
synonym: "negative regulation of CLMF secretion" RELATED [GOC:obol]
synonym: "negative regulation of IL-12 secretion" EXACT [GOC:obol]
synonym: "negative regulation of IL12 secretion" EXACT [GOC:obol]
synonym: "negative regulation of interleukin-12 complex secretion" EXACT [GOC:obol]
synonym: "negative regulation of NKSF secretion" RELATED [GOC:obol]
is_a: GO:0032695 ! negative regulation of interleukin-12 production
is_a: GO:0050710 ! negative regulation of cytokine secretion
is_a: GO:2001182 ! regulation of interleukin-12 secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072610 ! interleukin-12 secretion
relationship: negatively_regulates GO:0072610 ! interleukin-12 secretion
created_by: yaf
creation_date: 2011-11-03T01:10:37Z

[Term]
id: GO:2001184
name: positive regulation of interleukin-12 secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of interleukin-12 secretion." [GOC:obol]
synonym: "positive regulation of CLMF secretion" RELATED [GOC:obol]
synonym: "positive regulation of IL-12 secretion" EXACT [GOC:obol]
synonym: "positive regulation of IL12 secretion" EXACT [GOC:obol]
synonym: "positive regulation of interleukin-12 complex secretion" EXACT [GOC:obol]
synonym: "positive regulation of NKSF secretion" RELATED [GOC:obol]
is_a: GO:0032735 ! positive regulation of interleukin-12 production
is_a: GO:0050715 ! positive regulation of cytokine secretion
is_a: GO:2001182 ! regulation of interleukin-12 secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072610 ! interleukin-12 secretion
relationship: positively_regulates GO:0072610 ! interleukin-12 secretion
created_by: yaf
creation_date: 2011-11-03T01:10:41Z

[Term]
id: GO:2001185
name: regulation of CD8-positive, alpha-beta T cell activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of CD8-positive, alpha-beta T cell activation." [GOC:obol]
is_a: GO:0046634 ! regulation of alpha-beta T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0036037 ! CD8-positive, alpha-beta T cell activation
relationship: regulates GO:0036037 ! CD8-positive, alpha-beta T cell activation
created_by: yaf
creation_date: 2011-11-03T01:16:51Z

[Term]
id: GO:2001186
name: negative regulation of CD8-positive, alpha-beta T cell activation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of CD8-positive, alpha-beta T cell activation." [GOC:obol]
is_a: GO:0046636 ! negative regulation of alpha-beta T cell activation
is_a: GO:2001185 ! regulation of CD8-positive, alpha-beta T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0036037 ! CD8-positive, alpha-beta T cell activation
relationship: negatively_regulates GO:0036037 ! CD8-positive, alpha-beta T cell activation
created_by: yaf
creation_date: 2011-11-03T01:16:57Z

[Term]
id: GO:2001187
name: positive regulation of CD8-positive, alpha-beta T cell activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell activation." [GOC:obol]
is_a: GO:0046635 ! positive regulation of alpha-beta T cell activation
is_a: GO:2001185 ! regulation of CD8-positive, alpha-beta T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0036037 ! CD8-positive, alpha-beta T cell activation
relationship: positively_regulates GO:0036037 ! CD8-positive, alpha-beta T cell activation
created_by: yaf
creation_date: 2011-11-03T01:17:02Z

[Term]
id: GO:2001188
name: regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell." [GOC:obol]
synonym: "regulation of T lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [GOC:obol]
synonym: "regulation of T-cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [GOC:obol]
synonym: "regulation of T-lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [GOC:obol]
is_a: GO:0002697 ! regulation of immune effector process
is_a: GO:0050776 ! regulation of immune response
is_a: GO:0050863 ! regulation of T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002291 ! T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
relationship: regulates GO:0002291 ! T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
created_by: yaf
creation_date: 2011-11-03T01:31:30Z

[Term]
id: GO:2001189
name: negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell." [GOC:obol]
synonym: "negative regulation of T lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [GOC:obol]
synonym: "negative regulation of T-cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [GOC:obol]
synonym: "negative regulation of T-lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [GOC:obol]
is_a: GO:0002698 ! negative regulation of immune effector process
is_a: GO:0050777 ! negative regulation of immune response
is_a: GO:0050868 ! negative regulation of T cell activation
is_a: GO:2001188 ! regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002291 ! T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
relationship: negatively_regulates GO:0002291 ! T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
created_by: yaf
creation_date: 2011-11-03T01:31:36Z

[Term]
id: GO:2001190
name: positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell." [GOC:obol]
synonym: "positive regulation of T lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [GOC:obol]
synonym: "positive regulation of T-cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [GOC:obol]
synonym: "positive regulation of T-lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [GOC:obol]
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0050778 ! positive regulation of immune response
is_a: GO:0050870 ! positive regulation of T cell activation
is_a: GO:2001188 ! regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002291 ! T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
relationship: positively_regulates GO:0002291 ! T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
created_by: yaf
creation_date: 2011-11-03T01:31:40Z

[Term]
id: GO:2001191
name: regulation of gamma-delta T cell activation involved in immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gamma-delta T cell activation involved in immune response." [GOC:obol]
synonym: "regulation of gamma-delta T cell activation during immune response" RELATED [GOC:obol]
synonym: "regulation of gamma-delta T lymphocyte activation during immune response" RELATED [GOC:obol]
synonym: "regulation of gamma-delta T-cell activation during immune response" RELATED [GOC:obol]
synonym: "regulation of gamma-delta T-lymphocyte activation during immune response" RELATED [GOC:obol]
is_a: GO:0002697 ! regulation of immune effector process
is_a: GO:0046643 ! regulation of gamma-delta T cell activation
is_a: GO:0050776 ! regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002290 ! gamma-delta T cell activation involved in immune response
relationship: regulates GO:0002290 ! gamma-delta T cell activation involved in immune response
created_by: yaf
creation_date: 2011-11-03T04:28:38Z

[Term]
id: GO:2001192
name: negative regulation of gamma-delta T cell activation involved in immune response
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of gamma-delta T cell activation involved in immune response." [GOC:obol]
synonym: "negative regulation of gamma-delta T cell activation during immune response" RELATED [GOC:obol]
synonym: "negative regulation of gamma-delta T lymphocyte activation during immune response" RELATED [GOC:obol]
synonym: "negative regulation of gamma-delta T-cell activation during immune response" RELATED [GOC:obol]
synonym: "negative regulation of gamma-delta T-lymphocyte activation during immune response" RELATED [GOC:obol]
is_a: GO:0002698 ! negative regulation of immune effector process
is_a: GO:0046644 ! negative regulation of gamma-delta T cell activation
is_a: GO:0050777 ! negative regulation of immune response
is_a: GO:2001191 ! regulation of gamma-delta T cell activation involved in immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002290 ! gamma-delta T cell activation involved in immune response
relationship: negatively_regulates GO:0002290 ! gamma-delta T cell activation involved in immune response
created_by: yaf
creation_date: 2011-11-03T04:28:44Z

[Term]
id: GO:2001193
name: positive regulation of gamma-delta T cell activation involved in immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of gamma-delta T cell activation involved in immune response." [GOC:obol]
synonym: "positive regulation of gamma-delta T cell activation during immune response" RELATED [GOC:obol]
synonym: "positive regulation of gamma-delta T lymphocyte activation during immune response" RELATED [GOC:obol]
synonym: "positive regulation of gamma-delta T-cell activation during immune response" RELATED [GOC:obol]
synonym: "positive regulation of gamma-delta T-lymphocyte activation during immune response" RELATED [GOC:obol]
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0046645 ! positive regulation of gamma-delta T cell activation
is_a: GO:0050778 ! positive regulation of immune response
is_a: GO:2001191 ! regulation of gamma-delta T cell activation involved in immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002290 ! gamma-delta T cell activation involved in immune response
relationship: positively_regulates GO:0002290 ! gamma-delta T cell activation involved in immune response
created_by: yaf
creation_date: 2011-11-03T04:28:48Z

[Term]
id: GO:2001194
name: regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lysine biosynthetic process via alpha-aminoadipate and saccharopine." [GOC:obol]
synonym: "regulation of lysine biosynthesis via aminoadipic acid and saccharopine" EXACT [GOC:obol]
synonym: "regulation of lysine biosynthetic process via aminoadipic acid and saccharopine" EXACT [GOC:obol]
is_a: GO:1902986 ! regulation of lysine biosynthetic process via aminoadipic acid
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051975 ! lysine biosynthetic process via alpha-aminoadipate and saccharopine
relationship: regulates GO:0051975 ! lysine biosynthetic process via alpha-aminoadipate and saccharopine
created_by: mcc
creation_date: 2011-11-03T07:57:11Z

[Term]
id: GO:2001195
name: negative regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lysine biosynthetic process via alpha-aminoadipate and saccharopine." [GOC:obol]
synonym: "negative regulation of lysine biosynthesis via aminoadipic acid and saccharopine" EXACT [GOC:obol]
synonym: "negative regulation of lysine biosynthetic process via aminoadipic acid and saccharopine" EXACT [GOC:obol]
is_a: GO:1902987 ! negative regulation of lysine biosynthetic process via aminoadipic acid
is_a: GO:2001194 ! regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051975 ! lysine biosynthetic process via alpha-aminoadipate and saccharopine
relationship: negatively_regulates GO:0051975 ! lysine biosynthetic process via alpha-aminoadipate and saccharopine
created_by: mcc
creation_date: 2011-11-03T07:57:18Z

[Term]
id: GO:2001196
name: positive regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lysine biosynthetic process via alpha-aminoadipate and saccharopine." [GOC:obol]
synonym: "positive regulation of lysine biosynthesis via aminoadipic acid and saccharopine" EXACT [GOC:obol]
synonym: "positive regulation of lysine biosynthetic process via aminoadipic acid and saccharopine" EXACT [GOC:obol]
is_a: GO:2000284 ! positive regulation of cellular amino acid biosynthetic process
is_a: GO:2001194 ! regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051975 ! lysine biosynthetic process via alpha-aminoadipate and saccharopine
relationship: positively_regulates GO:0051975 ! lysine biosynthetic process via alpha-aminoadipate and saccharopine
created_by: mcc
creation_date: 2011-11-03T07:57:24Z

[Term]
id: GO:2001197
name: basement membrane assembly involved in embryonic body morphogenesis
namespace: biological_process
def: "Any basement membrane assembly that is involved in embryonic body morphogenesis." [GOC:obol]
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
is_a: GO:0070831 ! basement membrane assembly
intersection_of: GO:0070831 ! basement membrane assembly
intersection_of: part_of GO:0010172 ! embryonic body morphogenesis
relationship: part_of GO:0010172 ! embryonic body morphogenesis
created_by: kmv
creation_date: 2011-11-03T08:44:33Z

[Term]
id: GO:2001198
name: regulation of dendritic cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dendritic cell differentiation." [GOC:obol]
is_a: GO:1902105 ! regulation of leukocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097028 ! dendritic cell differentiation
relationship: regulates GO:0097028 ! dendritic cell differentiation
created_by: yaf
creation_date: 2011-11-04T02:01:27Z

[Term]
id: GO:2001199
name: negative regulation of dendritic cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell differentiation." [GOC:obol]
is_a: GO:1902106 ! negative regulation of leukocyte differentiation
is_a: GO:2001198 ! regulation of dendritic cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097028 ! dendritic cell differentiation
relationship: negatively_regulates GO:0097028 ! dendritic cell differentiation
created_by: yaf
creation_date: 2011-11-04T02:01:33Z

[Term]
id: GO:2001200
name: positive regulation of dendritic cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of dendritic cell differentiation." [GOC:obol]
is_a: GO:1902107 ! positive regulation of leukocyte differentiation
is_a: GO:2001198 ! regulation of dendritic cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097028 ! dendritic cell differentiation
relationship: positively_regulates GO:0097028 ! dendritic cell differentiation
created_by: yaf
creation_date: 2011-11-04T02:01:36Z

[Term]
id: GO:2001201
name: regulation of transforming growth factor-beta secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transforming growth factor-beta secretion." [GOC:obol]
synonym: "regulation of TGF-beta secretion" EXACT [GOC:obol]
synonym: "regulation of TGFbeta secretion" EXACT [GOC:obol]
is_a: GO:0050707 ! regulation of cytokine secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0038044 ! transforming growth factor-beta secretion
relationship: regulates GO:0038044 ! transforming growth factor-beta secretion
created_by: yaf
creation_date: 2011-11-10T04:29:46Z

[Term]
id: GO:2001202
name: negative regulation of transforming growth factor-beta secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of transforming growth factor-beta secretion." [GOC:obol]
synonym: "negative regulation of TGF-beta secretion" EXACT [GOC:obol]
synonym: "negative regulation of TGFbeta secretion" EXACT [GOC:obol]
is_a: GO:0050710 ! negative regulation of cytokine secretion
is_a: GO:2001201 ! regulation of transforming growth factor-beta secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0038044 ! transforming growth factor-beta secretion
relationship: negatively_regulates GO:0038044 ! transforming growth factor-beta secretion
created_by: yaf
creation_date: 2011-11-10T04:29:52Z

[Term]
id: GO:2001203
name: positive regulation of transforming growth factor-beta secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transforming growth factor-beta secretion." [GOC:obol]
synonym: "positive regulation of TGF-beta secretion" EXACT [GOC:obol]
synonym: "positive regulation of TGFbeta secretion" EXACT [GOC:obol]
is_a: GO:0050715 ! positive regulation of cytokine secretion
is_a: GO:2001201 ! regulation of transforming growth factor-beta secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0038044 ! transforming growth factor-beta secretion
relationship: positively_regulates GO:0038044 ! transforming growth factor-beta secretion
created_by: yaf
creation_date: 2011-11-10T04:29:57Z

[Term]
id: GO:2001204
name: regulation of osteoclast development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of osteoclast development." [GOC:obol]
synonym: "regulation of osteoclast cell development" EXACT [GOC:obol]
is_a: GO:0045670 ! regulation of osteoclast differentiation
is_a: GO:0060284 ! regulation of cell development
is_a: GO:1903010 ! regulation of bone development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0036035 ! osteoclast development
relationship: regulates GO:0036035 ! osteoclast development
created_by: yaf
creation_date: 2011-11-10T10:58:59Z

[Term]
id: GO:2001205
name: negative regulation of osteoclast development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of osteoclast development." [GOC:obol]
synonym: "negative regulation of osteoclast cell development" EXACT [GOC:obol]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0045671 ! negative regulation of osteoclast differentiation
is_a: GO:1903011 ! negative regulation of bone development
is_a: GO:2001204 ! regulation of osteoclast development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0036035 ! osteoclast development
relationship: negatively_regulates GO:0036035 ! osteoclast development
created_by: yaf
creation_date: 2011-11-10T10:59:06Z

[Term]
id: GO:2001206
name: positive regulation of osteoclast development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of osteoclast development." [GOC:obol]
synonym: "positive regulation of osteoclast cell development" EXACT [GOC:obol]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0045672 ! positive regulation of osteoclast differentiation
is_a: GO:1903012 ! positive regulation of bone development
is_a: GO:2001204 ! regulation of osteoclast development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0036035 ! osteoclast development
relationship: positively_regulates GO:0036035 ! osteoclast development
created_by: yaf
creation_date: 2011-11-10T10:59:12Z

[Term]
id: GO:2001207
name: regulation of transcription elongation from RNA polymerase I promoter
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription elongation from RNA polymerase I promoter." [PMID:20299458]
synonym: "regulation of RNA elongation from Pol I promoter" EXACT [GOC:obol]
is_a: GO:0006356 ! regulation of transcription from RNA polymerase I promoter
is_a: GO:0032784 ! regulation of DNA-templated transcription, elongation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006362 ! transcription elongation from RNA polymerase I promoter
relationship: regulates GO:0006362 ! transcription elongation from RNA polymerase I promoter
created_by: se
creation_date: 2011-11-11T10:46:28Z

[Term]
id: GO:2001208
name: negative regulation of transcription elongation from RNA polymerase I promoter
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription elongation from RNA polymerase I promoter." [PMID:20299458]
synonym: "negative regulation of RNA elongation from Pol I promoter" EXACT [GOC:obol]
is_a: GO:0016479 ! negative regulation of transcription from RNA polymerase I promoter
is_a: GO:0032785 ! negative regulation of DNA-templated transcription, elongation
is_a: GO:2001207 ! regulation of transcription elongation from RNA polymerase I promoter
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006362 ! transcription elongation from RNA polymerase I promoter
relationship: negatively_regulates GO:0006362 ! transcription elongation from RNA polymerase I promoter
created_by: se
creation_date: 2011-11-11T10:46:36Z

[Term]
id: GO:2001209
name: positive regulation of transcription elongation from RNA polymerase I promoter
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transcription elongation from RNA polymerase I promoter." [PMID:20299458]
synonym: "positive regulation of RNA elongation from Pol I promoter" EXACT [GOC:obol]
is_a: GO:0032786 ! positive regulation of DNA-templated transcription, elongation
is_a: GO:0045943 ! positive regulation of transcription from RNA polymerase I promoter
is_a: GO:2001207 ! regulation of transcription elongation from RNA polymerase I promoter
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006362 ! transcription elongation from RNA polymerase I promoter
relationship: positively_regulates GO:0006362 ! transcription elongation from RNA polymerase I promoter
created_by: se
creation_date: 2011-11-11T10:46:41Z

[Term]
id: GO:2001210
name: regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of isopentenyl diphosphate biosynthetic process, mevalonate pathway." [GOC:al]
synonym: "regulation of Ac-MVA pathway" EXACT [GOC:obol]
synonym: "regulation of acetate-mevalonate pathway" EXACT [GOC:obol]
synonym: "regulation of isopentenyl diphosphate anabolism, mevalonate pathway" EXACT [GOC:obol]
synonym: "regulation of isopentenyl diphosphate formation, mevalonate pathway" EXACT [GOC:obol]
synonym: "regulation of isopentenyl diphosphate synthesis, mevalonate pathway" EXACT [GOC:obol]
is_a: GO:0019747 ! regulation of isoprenoid metabolic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
is_a: GO:0051196 ! regulation of coenzyme metabolic process
is_a: GO:0071071 ! regulation of phospholipid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019287 ! isopentenyl diphosphate biosynthetic process, mevalonate pathway
relationship: regulates GO:0019287 ! isopentenyl diphosphate biosynthetic process, mevalonate pathway
created_by: rfoulger
creation_date: 2011-11-15T10:53:42Z

[Term]
id: GO:2001211
name: negative regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of isopentenyl diphosphate biosynthetic process, mevalonate pathway." [GOC:al]
synonym: "negative regulation of Ac-MVA pathway" EXACT [GOC:obol]
synonym: "negative regulation of acetate-mevalonate pathway" EXACT [GOC:obol]
synonym: "negative regulation of isopentenyl diphosphate anabolism, mevalonate pathway" EXACT [GOC:obol]
synonym: "negative regulation of isopentenyl diphosphate formation, mevalonate pathway" EXACT [GOC:obol]
synonym: "negative regulation of isopentenyl diphosphate synthesis, mevalonate pathway" EXACT [GOC:obol]
is_a: GO:0045827 ! negative regulation of isoprenoid metabolic process
is_a: GO:0051175 ! negative regulation of sulfur metabolic process
is_a: GO:0051198 ! negative regulation of coenzyme metabolic process
is_a: GO:0071072 ! negative regulation of phospholipid biosynthetic process
is_a: GO:2001210 ! regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019287 ! isopentenyl diphosphate biosynthetic process, mevalonate pathway
relationship: negatively_regulates GO:0019287 ! isopentenyl diphosphate biosynthetic process, mevalonate pathway
created_by: rfoulger
creation_date: 2011-11-15T10:53:45Z

[Term]
id: GO:2001212
name: regulation of vasculogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vasculogenesis." [GOC:obol]
synonym: "regulation of vascular morphogenesis" EXACT [GOC:obol]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:1901342 ! regulation of vasculature development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001570 ! vasculogenesis
relationship: regulates GO:0001570 ! vasculogenesis
created_by: yaf
creation_date: 2011-11-15T01:22:31Z

[Term]
id: GO:2001213
name: negative regulation of vasculogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vasculogenesis." [GOC:obol]
synonym: "negative regulation of vascular morphogenesis" EXACT [GOC:obol]
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:2000181 ! negative regulation of blood vessel morphogenesis
is_a: GO:2001212 ! regulation of vasculogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001570 ! vasculogenesis
relationship: negatively_regulates GO:0001570 ! vasculogenesis
created_by: yaf
creation_date: 2011-11-15T01:22:36Z

[Term]
id: GO:2001214
name: positive regulation of vasculogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vasculogenesis." [GOC:obol]
synonym: "positive regulation of vascular morphogenesis" EXACT [GOC:obol]
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:1904018 ! positive regulation of vasculature development
is_a: GO:2001212 ! regulation of vasculogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001570 ! vasculogenesis
relationship: positively_regulates GO:0001570 ! vasculogenesis
created_by: yaf
creation_date: 2011-11-15T01:22:39Z

[Term]
id: GO:2001215
name: regulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hydroxymethylglutaryl-CoA reductase (NADPH) activity." [GOC:al]
synonym: "regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity" RELATED [GOC:obol]
synonym: "regulation of HMG-CoA reductase activity" RELATED [GOC:obol]
is_a: GO:0051341 ! regulation of oxidoreductase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004420 ! hydroxymethylglutaryl-CoA reductase (NADPH) activity
relationship: regulates GO:0004420 ! hydroxymethylglutaryl-CoA reductase (NADPH) activity
created_by: rfoulger
creation_date: 2011-11-16T11:34:11Z

[Term]
id: GO:2001216
name: negative regulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hydroxymethylglutaryl-CoA reductase (NADPH) activity." [GOC:al]
synonym: "negative regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity" RELATED [GOC:obol]
synonym: "negative regulation of HMG-CoA reductase activity" RELATED [GOC:obol]
is_a: GO:0051354 ! negative regulation of oxidoreductase activity
is_a: GO:2001215 ! regulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004420 ! hydroxymethylglutaryl-CoA reductase (NADPH) activity
relationship: negatively_regulates GO:0004420 ! hydroxymethylglutaryl-CoA reductase (NADPH) activity
created_by: rfoulger
creation_date: 2011-11-16T11:34:17Z

[Term]
id: GO:2001217
name: obsolete regulation of S/G2 transition of mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of S/G2 transition of mitotic cell cycle." [GOC:mtg_cell_cycle, GOC:obol]
comment: This term was made obsolete because it does not refer to a real biological process.
synonym: "regulation of S/G2 transition of mitotic cell cycle" EXACT []
is_obsolete: true
consider: GO:0044770
created_by: dph
creation_date: 2011-11-16T09:14:42Z

[Term]
id: GO:2001218
name: obsolete negative regulation of S/G2 transition of mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of S/G2 transition of mitotic cell cycle." [GOC:mtg_cell_cycle, GOC:obol]
comment: This term was made obsolete because it does not refer to a real biological process.
synonym: "negative regulation of S/G2 transition of mitotic cell cycle" EXACT []
is_obsolete: true
created_by: dph
creation_date: 2011-11-16T09:14:47Z

[Term]
id: GO:2001219
name: obsolete positive regulation of S/G2 transition of mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of S/G2 transition of mitotic cell cycle." [GOC:mtg_cell_cycle, GOC:obol]
comment: This term was made obsolete because it does not refer to a real biological process.
synonym: "positive regulation of S/G2 transition of mitotic cell cycle" EXACT []
is_obsolete: true
created_by: dph
creation_date: 2011-11-16T09:14:50Z

[Term]
id: GO:2001220
name: obsolete negative regulation of G2 phase of mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of G2 phase of mitotic cell cycle." [GOC:mtg_cell_cycle, GOC:obol]
comment: This term was made obsolete because it does not refer to a real biological process.
synonym: "negative regulation of G2 phase of mitotic cell cycle" EXACT []
is_obsolete: true
created_by: yaf
creation_date: 2011-11-17T03:28:44Z

[Term]
id: GO:2001221
name: obsolete positive regulation of G2 phase of mitotic cell cycle
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of G2 phase of mitotic cell cycle." [GOC:mtg_cell_cycle, GOC:obol]
comment: This term was made obsolete because it does not refer to a real biological process.
synonym: "positive regulation of G2 phase of mitotic cell cycle" EXACT []
is_obsolete: true
created_by: yaf
creation_date: 2011-11-17T03:28:48Z

[Term]
id: GO:2001222
name: regulation of neuron migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neuron migration." [GOC:obol]
synonym: "regulation of neuron chemotaxis" EXACT [GOC:obol]
synonym: "regulation of neuron guidance" RELATED [GOC:obol]
synonym: "regulation of neuronal migration" EXACT [GOC:obol]
is_a: GO:0030334 ! regulation of cell migration
is_a: GO:0050767 ! regulation of neurogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001764 ! neuron migration
relationship: regulates GO:0001764 ! neuron migration
created_by: kmv
creation_date: 2011-11-17T10:01:38Z

[Term]
id: GO:2001223
name: negative regulation of neuron migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuron migration." [GOC:obol]
synonym: "negative regulation of neuron chemotaxis" EXACT [GOC:obol]
synonym: "negative regulation of neuron guidance" RELATED [GOC:obol]
synonym: "negative regulation of neuronal migration" EXACT [GOC:obol]
is_a: GO:0030336 ! negative regulation of cell migration
is_a: GO:0050768 ! negative regulation of neurogenesis
is_a: GO:2001222 ! regulation of neuron migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001764 ! neuron migration
relationship: negatively_regulates GO:0001764 ! neuron migration
created_by: kmv
creation_date: 2011-11-17T10:01:45Z

[Term]
id: GO:2001224
name: positive regulation of neuron migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neuron migration." [GOC:obol]
synonym: "positive regulation of neuron chemotaxis" EXACT [GOC:obol]
synonym: "positive regulation of neuron guidance" RELATED [GOC:obol]
synonym: "positive regulation of neuronal migration" EXACT [GOC:obol]
is_a: GO:0030335 ! positive regulation of cell migration
is_a: GO:0050769 ! positive regulation of neurogenesis
is_a: GO:2001222 ! regulation of neuron migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001764 ! neuron migration
relationship: positively_regulates GO:0001764 ! neuron migration
created_by: kmv
creation_date: 2011-11-17T10:01:49Z

[Term]
id: GO:2001225
name: regulation of chloride transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chloride transport." [GOC:dph]
is_a: GO:0044070 ! regulation of anion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006821 ! chloride transport
relationship: regulates GO:0006821 ! chloride transport
created_by: dph
creation_date: 2011-11-18T05:45:56Z

[Term]
id: GO:2001226
name: negative regulation of chloride transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chloride transport." [GOC:dph]
is_a: GO:1903792 ! negative regulation of anion transport
is_a: GO:2001225 ! regulation of chloride transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006821 ! chloride transport
relationship: negatively_regulates GO:0006821 ! chloride transport
created_by: dph
creation_date: 2011-11-18T05:46:03Z

[Term]
id: GO:2001227
name: quercitrin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with quercitrin." [GOC:obol]
is_a: GO:0043168 ! anion binding
is_a: GO:0097243 ! flavonoid binding
is_a: GO:0097367 ! carbohydrate derivative binding
created_by: tanyaberardini
creation_date: 2011-11-18T09:58:37Z

[Term]
id: GO:2001228
name: regulation of response to gamma radiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to gamma radiation." [GOC:obol]
synonym: "regulation of response to gamma ray" RELATED [GOC:obol]
synonym: "regulation of response to gamma-ray photon" RELATED [GOC:obol]
is_a: GO:0048583 ! regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010332 ! response to gamma radiation
relationship: regulates GO:0010332 ! response to gamma radiation
created_by: yaf
creation_date: 2011-11-20T04:51:07Z

[Term]
id: GO:2001229
name: negative regulation of response to gamma radiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to gamma radiation." [GOC:obol]
synonym: "negative regulation of response to gamma ray" RELATED [GOC:obol]
synonym: "negative regulation of response to gamma-ray photon" RELATED [GOC:obol]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:2001228 ! regulation of response to gamma radiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010332 ! response to gamma radiation
relationship: negatively_regulates GO:0010332 ! response to gamma radiation
created_by: yaf
creation_date: 2011-11-20T04:51:14Z

[Term]
id: GO:2001230
name: positive regulation of response to gamma radiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to gamma radiation." [GOC:obol]
synonym: "positive regulation of response to gamma ray" RELATED [GOC:obol]
synonym: "positive regulation of response to gamma-ray photon" RELATED [GOC:obol]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:2001228 ! regulation of response to gamma radiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010332 ! response to gamma radiation
relationship: positively_regulates GO:0010332 ! response to gamma radiation
created_by: yaf
creation_date: 2011-11-20T04:51:17Z

[Term]
id: GO:2001231
name: regulation of protein targeting to prospore membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein targeting to prospore membrane." [GOC:mah]
synonym: "regulation of protein targeting to ascospore-type prospore membrane" EXACT [GOC:obol]
synonym: "regulation of protein targeting to forespore membrane" RELATED [GOC:obol]
synonym: "regulation of protein targeting to FSM" EXACT [GOC:obol]
synonym: "regulation of protein-prospore membrane targeting" EXACT [GOC:obol]
is_a: GO:0090003 ! regulation of establishment of protein localization to plasma membrane
is_a: GO:0090313 ! regulation of protein targeting to membrane
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072693 ! protein targeting to prospore membrane
relationship: regulates GO:0072693 ! protein targeting to prospore membrane
created_by: midori
creation_date: 2011-11-21T04:13:30Z

[Term]
id: GO:2001232
name: positive regulation of protein targeting to prospore membrane
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein targeting to prospore membrane." [GOC:mah]
synonym: "positive regulation of protein targeting to ascospore-type prospore membrane" EXACT [GOC:obol]
synonym: "positive regulation of protein targeting to forespore membrane" RELATED [GOC:obol]
synonym: "positive regulation of protein targeting to FSM" EXACT [GOC:obol]
synonym: "positive regulation of protein-prospore membrane targeting" EXACT [GOC:obol]
is_a: GO:0090004 ! positive regulation of establishment of protein localization to plasma membrane
is_a: GO:0090314 ! positive regulation of protein targeting to membrane
is_a: GO:2001231 ! regulation of protein targeting to prospore membrane
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072693 ! protein targeting to prospore membrane
relationship: positively_regulates GO:0072693 ! protein targeting to prospore membrane
created_by: midori
creation_date: 2011-11-21T04:13:36Z

[Term]
id: GO:2001233
name: regulation of apoptotic signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis]
synonym: "regulation of apoptotic signalling pathway" EXACT [GOC:mah]
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0042981 ! regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097190 ! apoptotic signaling pathway
relationship: regulates GO:0097190 ! apoptotic signaling pathway
created_by: pr
creation_date: 2011-11-24T01:20:49Z

[Term]
id: GO:2001234
name: negative regulation of apoptotic signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis]
synonym: "negative regulation of apoptotic signalling pathway" EXACT [GOC:mah]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0043066 ! negative regulation of apoptotic process
is_a: GO:2001233 ! regulation of apoptotic signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097190 ! apoptotic signaling pathway
relationship: negatively_regulates GO:0097190 ! apoptotic signaling pathway
created_by: pr
creation_date: 2011-11-24T01:20:54Z

[Term]
id: GO:2001235
name: positive regulation of apoptotic signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis]
synonym: "positive regulation of apoptotic signalling pathway" EXACT [GOC:mah]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0043065 ! positive regulation of apoptotic process
is_a: GO:2001233 ! regulation of apoptotic signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097190 ! apoptotic signaling pathway
relationship: positively_regulates GO:0097190 ! apoptotic signaling pathway
created_by: pr
creation_date: 2011-11-24T01:20:58Z

[Term]
id: GO:2001236
name: regulation of extrinsic apoptotic signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis]
synonym: "regulation of extrinsic apoptosis" NARROW []
synonym: "regulation of extrinsic apoptotic signalling pathway" EXACT [GOC:mah]
is_a: GO:2001233 ! regulation of apoptotic signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097191 ! extrinsic apoptotic signaling pathway
relationship: regulates GO:0097191 ! extrinsic apoptotic signaling pathway
created_by: pr
creation_date: 2011-11-24T01:30:05Z

[Term]
id: GO:2001237
name: negative regulation of extrinsic apoptotic signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis]
synonym: "negative regulation of extrinsic apoptosis" NARROW []
synonym: "negative regulation of extrinsic apoptotic signalling pathway" EXACT [GOC:mah]
is_a: GO:2001234 ! negative regulation of apoptotic signaling pathway
is_a: GO:2001236 ! regulation of extrinsic apoptotic signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097191 ! extrinsic apoptotic signaling pathway
relationship: negatively_regulates GO:0097191 ! extrinsic apoptotic signaling pathway
created_by: pr
creation_date: 2011-11-24T01:30:11Z

[Term]
id: GO:2001238
name: positive regulation of extrinsic apoptotic signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis]
synonym: "positive regulation of extrinsic apoptosis" NARROW []
synonym: "positive regulation of extrinsic apoptotic signalling pathway" EXACT [GOC:mah]
is_a: GO:2001235 ! positive regulation of apoptotic signaling pathway
is_a: GO:2001236 ! regulation of extrinsic apoptotic signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097191 ! extrinsic apoptotic signaling pathway
relationship: positively_regulates GO:0097191 ! extrinsic apoptotic signaling pathway
created_by: pr
creation_date: 2011-11-24T01:30:16Z

[Term]
id: GO:2001239
name: regulation of extrinsic apoptotic signaling pathway in absence of ligand
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand." [GOC:mtg_apoptosis]
synonym: "regulation of dependence receptor signaling pathway" RELATED [GOC:obol]
synonym: "regulation of extrinsic apoptosis in absence of ligand" NARROW []
synonym: "regulation of extrinsic apoptotic signalling pathway in absence of ligand" EXACT [GOC:mah]
is_a: GO:2001236 ! regulation of extrinsic apoptotic signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097192 ! extrinsic apoptotic signaling pathway in absence of ligand
relationship: regulates GO:0097192 ! extrinsic apoptotic signaling pathway in absence of ligand
created_by: pr
creation_date: 2011-11-24T01:33:18Z

[Term]
id: GO:2001240
name: negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand." [GOC:mtg_apoptosis]
synonym: "negative regulation of dependence receptor signaling pathway" RELATED [GOC:obol]
synonym: "negative regulation of extrinsic apoptosis in absence of ligand" NARROW []
synonym: "negative regulation of extrinsic apoptotic signalling pathway in absence of ligand" EXACT [GOC:mah]
is_a: GO:1901099 ! negative regulation of signal transduction in absence of ligand
is_a: GO:2001237 ! negative regulation of extrinsic apoptotic signaling pathway
is_a: GO:2001239 ! regulation of extrinsic apoptotic signaling pathway in absence of ligand
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097192 ! extrinsic apoptotic signaling pathway in absence of ligand
relationship: negatively_regulates GO:0097192 ! extrinsic apoptotic signaling pathway in absence of ligand
created_by: pr
creation_date: 2011-11-24T01:33:25Z

[Term]
id: GO:2001241
name: positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand." [GOC:mtg_apoptosis]
synonym: "positive regulation of dependence receptor signaling pathway" RELATED [GOC:obol]
synonym: "positive regulation of extrinsic apoptosis in absence of ligand" NARROW []
synonym: "positive regulation of extrinsic apoptotic signalling pathway in absence of ligand" EXACT [GOC:mah]
is_a: GO:2001238 ! positive regulation of extrinsic apoptotic signaling pathway
is_a: GO:2001239 ! regulation of extrinsic apoptotic signaling pathway in absence of ligand
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097192 ! extrinsic apoptotic signaling pathway in absence of ligand
relationship: positively_regulates GO:0097192 ! extrinsic apoptotic signaling pathway in absence of ligand
created_by: pr
creation_date: 2011-11-24T01:33:31Z

[Term]
id: GO:2001242
name: regulation of intrinsic apoptotic signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis]
synonym: "regulation of intrinsic apoptosis" NARROW []
synonym: "regulation of intrinsic apoptotic pathway" EXACT [GOC:obol]
synonym: "regulation of intrinsic apoptotic signalling pathway" EXACT [GOC:mah]
synonym: "regulation of mitochondrial-mediated apoptotic pathway" EXACT [GOC:obol]
is_a: GO:1902531 ! regulation of intracellular signal transduction
is_a: GO:2001233 ! regulation of apoptotic signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097193 ! intrinsic apoptotic signaling pathway
relationship: regulates GO:0097193 ! intrinsic apoptotic signaling pathway
created_by: pr
creation_date: 2011-11-24T01:35:56Z

[Term]
id: GO:2001243
name: negative regulation of intrinsic apoptotic signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis]
synonym: "negative regulation of intrinsic apoptosis" NARROW []
synonym: "negative regulation of intrinsic apoptotic pathway" EXACT [GOC:obol]
synonym: "negative regulation of intrinsic apoptotic signalling pathway" EXACT [GOC:mah]
synonym: "negative regulation of mitochondrial-mediated apoptotic pathway" EXACT [GOC:obol]
is_a: GO:1902532 ! negative regulation of intracellular signal transduction
is_a: GO:2001234 ! negative regulation of apoptotic signaling pathway
is_a: GO:2001242 ! regulation of intrinsic apoptotic signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097193 ! intrinsic apoptotic signaling pathway
relationship: negatively_regulates GO:0097193 ! intrinsic apoptotic signaling pathway
created_by: pr
creation_date: 2011-11-24T01:36:03Z

[Term]
id: GO:2001244
name: positive regulation of intrinsic apoptotic signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis]
synonym: "positive regulation of intrinsic apoptosis" NARROW []
synonym: "positive regulation of intrinsic apoptotic pathway" EXACT [GOC:obol]
synonym: "positive regulation of intrinsic apoptotic signalling pathway" EXACT [GOC:mah]
synonym: "positive regulation of mitochondrial-mediated apoptotic pathway" EXACT [GOC:obol]
is_a: GO:1902533 ! positive regulation of intracellular signal transduction
is_a: GO:2001235 ! positive regulation of apoptotic signaling pathway
is_a: GO:2001242 ! regulation of intrinsic apoptotic signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097193 ! intrinsic apoptotic signaling pathway
relationship: positively_regulates GO:0097193 ! intrinsic apoptotic signaling pathway
created_by: pr
creation_date: 2011-11-24T01:36:07Z

[Term]
id: GO:2001245
name: regulation of phosphatidylcholine biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phosphatidylcholine biosynthetic process." [GOC:obol]
synonym: "regulation of phosphatidylcholine anabolism" EXACT [GOC:obol]
synonym: "regulation of phosphatidylcholine biosynthesis" EXACT [GOC:obol]
synonym: "regulation of phosphatidylcholine formation" EXACT [GOC:obol]
synonym: "regulation of phosphatidylcholine synthesis" EXACT [GOC:obol]
is_a: GO:0033238 ! regulation of cellular amine metabolic process
is_a: GO:0071071 ! regulation of phospholipid biosynthetic process
is_a: GO:1902930 ! regulation of alcohol biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006656 ! phosphatidylcholine biosynthetic process
relationship: regulates GO:0006656 ! phosphatidylcholine biosynthetic process
created_by: tanyaberardini
creation_date: 2011-11-28T09:47:32Z

[Term]
id: GO:2001246
name: negative regulation of phosphatidylcholine biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylcholine biosynthetic process." [GOC:obol]
synonym: "negative regulation of phosphatidylcholine anabolism" EXACT [GOC:obol]
synonym: "negative regulation of phosphatidylcholine biosynthesis" EXACT [GOC:obol]
synonym: "negative regulation of phosphatidylcholine formation" EXACT [GOC:obol]
synonym: "negative regulation of phosphatidylcholine synthesis" EXACT [GOC:obol]
is_a: GO:0033239 ! negative regulation of cellular amine metabolic process
is_a: GO:0071072 ! negative regulation of phospholipid biosynthetic process
is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process
is_a: GO:2001245 ! regulation of phosphatidylcholine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006656 ! phosphatidylcholine biosynthetic process
relationship: negatively_regulates GO:0006656 ! phosphatidylcholine biosynthetic process
created_by: tanyaberardini
creation_date: 2011-11-28T09:47:47Z

[Term]
id: GO:2001247
name: positive regulation of phosphatidylcholine biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phosphatidylcholine biosynthetic process." [GOC:obol]
synonym: "positive regulation of phosphatidylcholine anabolism" EXACT [GOC:obol]
synonym: "positive regulation of phosphatidylcholine biosynthesis" EXACT [GOC:obol]
synonym: "positive regulation of phosphatidylcholine formation" EXACT [GOC:obol]
synonym: "positive regulation of phosphatidylcholine synthesis" EXACT [GOC:obol]
is_a: GO:0033240 ! positive regulation of cellular amine metabolic process
is_a: GO:0071073 ! positive regulation of phospholipid biosynthetic process
is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process
is_a: GO:2001245 ! regulation of phosphatidylcholine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006656 ! phosphatidylcholine biosynthetic process
relationship: positively_regulates GO:0006656 ! phosphatidylcholine biosynthetic process
created_by: tanyaberardini
creation_date: 2011-11-28T09:47:54Z

[Term]
id: GO:2001248
name: regulation of ammonia assimilation cycle
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ammonia assimilation cycle." [GOC:BHF]
synonym: "regulation of glutamate metabolic process via glutamine and ammonia" EXACT [GOC:obol]
synonym: "regulation of glutamate metabolism via glutamine and ammonia" EXACT [GOC:obol]
is_a: GO:2000211 ! regulation of glutamate metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019676 ! ammonia assimilation cycle
relationship: regulates GO:0019676 ! ammonia assimilation cycle
created_by: rl
creation_date: 2011-12-01T10:08:21Z

[Term]
id: GO:2001249
name: negative regulation of ammonia assimilation cycle
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ammonia assimilation cycle." [GOC:BHF]
synonym: "negative regulation of glutamate metabolic process via glutamine and ammonia" EXACT [GOC:obol]
synonym: "negative regulation of glutamate metabolism via glutamine and ammonia" EXACT [GOC:obol]
is_a: GO:2000212 ! negative regulation of glutamate metabolic process
is_a: GO:2001248 ! regulation of ammonia assimilation cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019676 ! ammonia assimilation cycle
relationship: negatively_regulates GO:0019676 ! ammonia assimilation cycle
created_by: rl
creation_date: 2011-12-01T10:08:29Z

[Term]
id: GO:2001250
name: positive regulation of ammonia assimilation cycle
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ammonia assimilation cycle." [GOC:BHF]
synonym: "positive regulation of glutamate metabolic process via glutamine and ammonia" EXACT [GOC:obol]
synonym: "positive regulation of glutamate metabolism via glutamine and ammonia" EXACT [GOC:obol]
is_a: GO:2000213 ! positive regulation of glutamate metabolic process
is_a: GO:2001248 ! regulation of ammonia assimilation cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0019676 ! ammonia assimilation cycle
relationship: positively_regulates GO:0019676 ! ammonia assimilation cycle
created_by: rl
creation_date: 2011-12-01T10:08:34Z

[Term]
id: GO:2001251
name: negative regulation of chromosome organization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chromosome organization." [GOC:obol]
synonym: "negative regulation of chromosome organisation" EXACT [GOC:obol]
synonym: "negative regulation of chromosome organization and biogenesis" RELATED [GOC:obol]
synonym: "negative regulation of maintenance of genome integrity" RELATED [GOC:obol]
synonym: "negative regulation of nuclear genome maintenance" RELATED [GOC:obol]
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:0033044 ! regulation of chromosome organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051276 ! chromosome organization
relationship: negatively_regulates GO:0051276 ! chromosome organization
created_by: yaf
creation_date: 2011-12-02T02:01:20Z

[Term]
id: GO:2001252
name: positive regulation of chromosome organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chromosome organization." [GOC:obol]
synonym: "positive regulation of chromosome organisation" EXACT [GOC:obol]
synonym: "positive regulation of chromosome organization and biogenesis" RELATED [GOC:obol]
synonym: "positive regulation of maintenance of genome integrity" RELATED [GOC:obol]
synonym: "positive regulation of nuclear genome maintenance" RELATED [GOC:obol]
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:0033044 ! regulation of chromosome organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051276 ! chromosome organization
relationship: positively_regulates GO:0051276 ! chromosome organization
created_by: yaf
creation_date: 2011-12-02T02:01:26Z

[Term]
id: GO:2001253
name: regulation of histone H3-K36 trimethylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of histone H3-K36 trimethylation." [PMID:17948059]
is_a: GO:0000414 ! regulation of histone H3-K36 methylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097198 ! histone H3-K36 trimethylation
relationship: regulates GO:0097198 ! histone H3-K36 trimethylation
created_by: pr
creation_date: 2011-12-06T07:38:09Z

[Term]
id: GO:2001254
name: negative regulation of histone H3-K36 trimethylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K36 trimethylation." [PMID:17948059]
is_a: GO:0000415 ! negative regulation of histone H3-K36 methylation
is_a: GO:2001253 ! regulation of histone H3-K36 trimethylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097198 ! histone H3-K36 trimethylation
relationship: negatively_regulates GO:0097198 ! histone H3-K36 trimethylation
created_by: pr
creation_date: 2011-12-06T07:38:17Z

[Term]
id: GO:2001255
name: positive regulation of histone H3-K36 trimethylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of histone H3-K36 trimethylation." [PMID:17948059]
is_a: GO:0000416 ! positive regulation of histone H3-K36 methylation
is_a: GO:2001253 ! regulation of histone H3-K36 trimethylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097198 ! histone H3-K36 trimethylation
relationship: positively_regulates GO:0097198 ! histone H3-K36 trimethylation
created_by: pr
creation_date: 2011-12-06T07:38:24Z

[Term]
id: GO:2001256
name: regulation of store-operated calcium entry
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of store-operated calcium entry." [GOC:BHF]
synonym: "regulation of calcium ion import" RELATED [GOC:obol]
synonym: "regulation of capacitative calcium entry" EXACT [GOC:obol]
synonym: "regulation of SOCE" EXACT [GOC:obol]
synonym: "regulation of store-operated calcium import" EXACT [GOC:obol]
is_a: GO:0051924 ! regulation of calcium ion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002115 ! store-operated calcium entry
relationship: regulates GO:0002115 ! store-operated calcium entry
created_by: vk
creation_date: 2011-12-07T07:08:38Z

[Term]
id: GO:2001257
name: regulation of cation channel activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cation channel activity." [GOC:BHF]
synonym: "regulation of cation diffusion facilitator activity" EXACT [GOC:obol]
synonym: "regulation of nonselective cation channel activity" EXACT [GOC:obol]
is_a: GO:0032412 ! regulation of ion transmembrane transporter activity
is_a: GO:1904062 ! regulation of cation transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0005261 ! cation channel activity
relationship: regulates GO:0005261 ! cation channel activity
created_by: vk
creation_date: 2011-12-07T07:14:43Z

[Term]
id: GO:2001258
name: negative regulation of cation channel activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cation channel activity." [GOC:BHF]
synonym: "negative regulation of cation diffusion facilitator activity" EXACT [GOC:obol]
synonym: "negative regulation of nonselective cation channel activity" EXACT [GOC:obol]
is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity
is_a: GO:1904063 ! negative regulation of cation transmembrane transport
is_a: GO:2001257 ! regulation of cation channel activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0005261 ! cation channel activity
relationship: negatively_regulates GO:0005261 ! cation channel activity
created_by: vk
creation_date: 2011-12-07T07:14:51Z

[Term]
id: GO:2001259
name: positive regulation of cation channel activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cation channel activity." [GOC:BHF]
synonym: "positive regulation of cation diffusion facilitator activity" EXACT [GOC:obol]
synonym: "positive regulation of nonselective cation channel activity" EXACT [GOC:obol]
is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity
is_a: GO:1904064 ! positive regulation of cation transmembrane transport
is_a: GO:2001257 ! regulation of cation channel activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0005261 ! cation channel activity
relationship: positively_regulates GO:0005261 ! cation channel activity
created_by: vk
creation_date: 2011-12-07T07:14:57Z

[Term]
id: GO:2001260
name: regulation of semaphorin-plexin signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of semaphorin-plexin signaling pathway." [GOC:BHF]
synonym: "regulation of semaphorin-plexin signalling pathway" EXACT [GOC:obol]
is_a: GO:0009966 ! regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071526 ! semaphorin-plexin signaling pathway
relationship: regulates GO:0071526 ! semaphorin-plexin signaling pathway
created_by: vk
creation_date: 2011-12-08T02:05:41Z

[Term]
id: GO:2001261
name: negative regulation of semaphorin-plexin signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of semaphorin-plexin signaling pathway." [GOC:BHF]
synonym: "negative regulation of semaphorin-plexin signalling pathway" EXACT [GOC:obol]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:2001260 ! regulation of semaphorin-plexin signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071526 ! semaphorin-plexin signaling pathway
relationship: negatively_regulates GO:0071526 ! semaphorin-plexin signaling pathway
created_by: vk
creation_date: 2011-12-08T02:05:48Z

[Term]
id: GO:2001262
name: positive regulation of semaphorin-plexin signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of semaphorin-plexin signaling pathway." [GOC:BHF]
synonym: "positive regulation of semaphorin-plexin signalling pathway" EXACT [GOC:obol]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:2001260 ! regulation of semaphorin-plexin signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071526 ! semaphorin-plexin signaling pathway
relationship: positively_regulates GO:0071526 ! semaphorin-plexin signaling pathway
created_by: vk
creation_date: 2011-12-08T02:05:53Z

[Term]
id: GO:2001263
name: regulation of C-C chemokine binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of C-C chemokine binding." [GOC:obol]
is_a: GO:0043393 ! regulation of protein binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019957 ! C-C chemokine binding
relationship: regulates GO:0019957 ! C-C chemokine binding
created_by: yaf
creation_date: 2011-12-09T01:13:54Z

[Term]
id: GO:2001264
name: negative regulation of C-C chemokine binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of C-C chemokine binding." [GOC:obol]
is_a: GO:0032091 ! negative regulation of protein binding
is_a: GO:2001263 ! regulation of C-C chemokine binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019957 ! C-C chemokine binding
relationship: negatively_regulates GO:0019957 ! C-C chemokine binding
created_by: yaf
creation_date: 2011-12-09T01:14:01Z

[Term]
id: GO:2001265
name: positive regulation of C-C chemokine binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of C-C chemokine binding." [GOC:obol]
is_a: GO:0032092 ! positive regulation of protein binding
is_a: GO:2001263 ! regulation of C-C chemokine binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0019957 ! C-C chemokine binding
relationship: positively_regulates GO:0019957 ! C-C chemokine binding
created_by: yaf
creation_date: 2011-12-09T01:14:07Z

[Term]
id: GO:2001266
name: Roundabout signaling pathway involved in axon guidance
namespace: biological_process
def: "Any Roundabout signaling pathway that is involved in axon guidance." [GOC:bf, PMID:14527427, PMID:21820427]
synonym: "ROBO signaling pathway involved in axon chemotaxis" RELATED [GOC:obol]
synonym: "ROBO signaling pathway involved in axon growth cone guidance" RELATED [GOC:obol]
synonym: "ROBO signaling pathway involved in axon guidance" EXACT [GOC:obol]
synonym: "ROBO signaling pathway involved in axon pathfinding" EXACT [GOC:obol]
synonym: "ROBO/SLIT signaling pathway involved in axon chemotaxis" RELATED [GOC:obol]
synonym: "ROBO/SLIT signaling pathway involved in axon growth cone guidance" RELATED [GOC:obol]
synonym: "ROBO/SLIT signaling pathway involved in axon guidance" EXACT [GOC:obol]
synonym: "ROBO/SLIT signaling pathway involved in axon pathfinding" EXACT [GOC:obol]
synonym: "Roundabout signaling pathway involved in axon chemotaxis" RELATED [GOC:obol]
synonym: "Roundabout signaling pathway involved in axon growth cone guidance" RELATED [GOC:obol]
synonym: "Roundabout signaling pathway involved in axon pathfinding" EXACT [GOC:obol]
synonym: "Roundabout signalling pathway involved in axon chemotaxis" RELATED [GOC:obol]
synonym: "Roundabout signalling pathway involved in axon growth cone guidance" RELATED [GOC:obol]
synonym: "Roundabout signalling pathway involved in axon guidance" EXACT [GOC:obol]
synonym: "Roundabout signalling pathway involved in axon pathfinding" EXACT [GOC:obol]
is_a: GO:0035385 ! Roundabout signaling pathway
intersection_of: GO:0035385 ! Roundabout signaling pathway
intersection_of: part_of GO:0007411 ! axon guidance
relationship: part_of GO:0007411 ! axon guidance
created_by: rfoulger
creation_date: 2011-12-12T03:40:20Z

[Term]
id: GO:2001267
name: regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cysteine-type endopeptidase activity involved in apoptotic signaling pathway." [GOC:mtg_apoptosis]
synonym: "regulation of cysteine-type endopeptidase activity involved in apoptotic signalling pathway" EXACT [GOC:mah]
synonym: "regulation of initiator caspase activity" NARROW [GOC:obol]
is_a: GO:0043281 ! regulation of cysteine-type endopeptidase activity involved in apoptotic process
is_a: GO:2001233 ! regulation of apoptotic signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097199 ! cysteine-type endopeptidase activity involved in apoptotic signaling pathway
relationship: regulates GO:0097199 ! cysteine-type endopeptidase activity involved in apoptotic signaling pathway
created_by: pr
creation_date: 2011-12-13T07:56:13Z

[Term]
id: GO:2001268
name: negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cysteine-type endopeptidase activity involved in apoptotic signaling pathway." [GOC:mtg_apoptosis]
synonym: "negative regulation of cysteine-type endopeptidase activity involved in apoptotic signalling pathway" EXACT [GOC:mah]
synonym: "negative regulation of initiator caspase activity" NARROW [GOC:obol]
is_a: GO:0043154 ! negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
is_a: GO:2001234 ! negative regulation of apoptotic signaling pathway
is_a: GO:2001267 ! regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097199 ! cysteine-type endopeptidase activity involved in apoptotic signaling pathway
relationship: negatively_regulates GO:0097199 ! cysteine-type endopeptidase activity involved in apoptotic signaling pathway
created_by: pr
creation_date: 2011-12-13T07:56:21Z

[Term]
id: GO:2001269
name: positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cysteine-type endopeptidase activity involved in apoptotic signaling pathway." [GOC:mtg_apoptosis]
synonym: "positive regulation of cysteine-type endopeptidase activity involved in apoptotic signalling pathway" EXACT [GOC:mah]
synonym: "positive regulation of initiator caspase activity" NARROW [GOC:obol]
is_a: GO:0043280 ! positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
is_a: GO:2001235 ! positive regulation of apoptotic signaling pathway
is_a: GO:2001267 ! regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097199 ! cysteine-type endopeptidase activity involved in apoptotic signaling pathway
relationship: positively_regulates GO:0097199 ! cysteine-type endopeptidase activity involved in apoptotic signaling pathway
created_by: pr
creation_date: 2011-12-13T07:56:26Z

[Term]
id: GO:2001270
name: regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cysteine-type endopeptidase activity involved in execution phase of apoptosis." [GOC:mtg_apoptosis]
synonym: "regulation of effector caspase activity" NARROW [GOC:obol]
is_a: GO:0043281 ! regulation of cysteine-type endopeptidase activity involved in apoptotic process
is_a: GO:1900117 ! regulation of execution phase of apoptosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097200 ! cysteine-type endopeptidase activity involved in execution phase of apoptosis
relationship: regulates GO:0097200 ! cysteine-type endopeptidase activity involved in execution phase of apoptosis
created_by: pr
creation_date: 2011-12-13T07:59:36Z

[Term]
id: GO:2001271
name: negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cysteine-type endopeptidase activity involved in execution phase of apoptosis." [GOC:mtg_apoptosis]
synonym: "negative regulation of effector caspase activity" NARROW [GOC:obol]
is_a: GO:0043154 ! negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
is_a: GO:1900118 ! negative regulation of execution phase of apoptosis
is_a: GO:2001270 ! regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097200 ! cysteine-type endopeptidase activity involved in execution phase of apoptosis
relationship: negatively_regulates GO:0097200 ! cysteine-type endopeptidase activity involved in execution phase of apoptosis
created_by: pr
creation_date: 2011-12-13T07:59:42Z

[Term]
id: GO:2001272
name: positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cysteine-type endopeptidase activity involved in execution phase of apoptosis." [GOC:mtg_apoptosis]
synonym: "positive regulation of effector caspase activity" NARROW [GOC:obol]
is_a: GO:0043280 ! positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
is_a: GO:1900119 ! positive regulation of execution phase of apoptosis
is_a: GO:2001270 ! regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097200 ! cysteine-type endopeptidase activity involved in execution phase of apoptosis
relationship: positively_regulates GO:0097200 ! cysteine-type endopeptidase activity involved in execution phase of apoptosis
created_by: pr
creation_date: 2011-12-13T07:59:47Z

[Term]
id: GO:2001273
name: regulation of glucose import in response to insulin stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glucose import in response to insulin stimulus." [GOC:BHF]
synonym: "regulation of cellular glucose import in response to insulin stimulus" EXACT [GOC:obol]
is_a: GO:0046324 ! regulation of glucose import
is_a: GO:1900076 ! regulation of cellular response to insulin stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044381 ! glucose import in response to insulin stimulus
relationship: regulates GO:0044381 ! glucose import in response to insulin stimulus
created_by: vk
creation_date: 2011-12-13T12:29:31Z

[Term]
id: GO:2001274
name: negative regulation of glucose import in response to insulin stimulus
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glucose import in response to insulin stimulus." [GOC:BHF]
synonym: "negative regulation of cellular glucose import in response to insulin stimulus" EXACT [GOC:obol]
is_a: GO:0046325 ! negative regulation of glucose import
is_a: GO:1900077 ! negative regulation of cellular response to insulin stimulus
is_a: GO:2001273 ! regulation of glucose import in response to insulin stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044381 ! glucose import in response to insulin stimulus
relationship: negatively_regulates GO:0044381 ! glucose import in response to insulin stimulus
created_by: vk
creation_date: 2011-12-13T12:29:38Z

[Term]
id: GO:2001275
name: positive regulation of glucose import in response to insulin stimulus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glucose import in response to insulin stimulus." [GOC:BHF]
synonym: "positive regulation of cellular glucose import in response to insulin stimulus" EXACT [GOC:obol]
is_a: GO:0046326 ! positive regulation of glucose import
is_a: GO:1900078 ! positive regulation of cellular response to insulin stimulus
is_a: GO:2001273 ! regulation of glucose import in response to insulin stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044381 ! glucose import in response to insulin stimulus
relationship: positively_regulates GO:0044381 ! glucose import in response to insulin stimulus
created_by: vk
creation_date: 2011-12-13T12:29:43Z

[Term]
id: GO:2001276
name: regulation of leucine biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of leucine biosynthetic process." [GOC:obol]
synonym: "regulation of leucine anabolism" EXACT [GOC:obol]
synonym: "regulation of leucine biosynthesis" EXACT [GOC:obol]
synonym: "regulation of leucine formation" EXACT [GOC:obol]
synonym: "regulation of leucine synthesis" EXACT [GOC:obol]
is_a: GO:2000282 ! regulation of cellular amino acid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009098 ! leucine biosynthetic process
relationship: regulates GO:0009098 ! leucine biosynthetic process
created_by: mcc
creation_date: 2011-12-13T03:13:27Z

[Term]
id: GO:2001277
name: negative regulation of leucine biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of leucine biosynthetic process." [GOC:obol]
synonym: "negative regulation of leucine anabolism" EXACT [GOC:obol]
synonym: "negative regulation of leucine biosynthesis" EXACT [GOC:obol]
synonym: "negative regulation of leucine formation" EXACT [GOC:obol]
synonym: "negative regulation of leucine synthesis" EXACT [GOC:obol]
is_a: GO:2000283 ! negative regulation of cellular amino acid biosynthetic process
is_a: GO:2001276 ! regulation of leucine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009098 ! leucine biosynthetic process
relationship: negatively_regulates GO:0009098 ! leucine biosynthetic process
created_by: mcc
creation_date: 2011-12-13T03:13:36Z

[Term]
id: GO:2001278
name: positive regulation of leucine biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of leucine biosynthetic process." [GOC:obol]
synonym: "positive regulation of leucine anabolism" EXACT [GOC:obol]
synonym: "positive regulation of leucine biosynthesis" EXACT [GOC:obol]
synonym: "positive regulation of leucine formation" EXACT [GOC:obol]
synonym: "positive regulation of leucine synthesis" EXACT [GOC:obol]
is_a: GO:2000284 ! positive regulation of cellular amino acid biosynthetic process
is_a: GO:2001276 ! regulation of leucine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009098 ! leucine biosynthetic process
relationship: positively_regulates GO:0009098 ! leucine biosynthetic process
created_by: mcc
creation_date: 2011-12-13T03:13:42Z

[Term]
id: GO:2001279
name: regulation of unsaturated fatty acid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of unsaturated fatty acid biosynthetic process." [GO:0006636]
synonym: "regulation of fatty acid desaturation" RELATED [GOC:obol]
synonym: "regulation of polyunsaturated fatty acid biosynthesis" RELATED [GOC:obol]
synonym: "regulation of unsaturated fatty acid anabolism" EXACT [GOC:obol]
synonym: "regulation of unsaturated fatty acid biosynthesis" EXACT [GOC:obol]
synonym: "regulation of unsaturated fatty acid formation" EXACT [GOC:obol]
synonym: "regulation of unsaturated fatty acid synthesis" EXACT [GOC:obol]
is_a: GO:0042304 ! regulation of fatty acid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006636 ! unsaturated fatty acid biosynthetic process
relationship: regulates GO:0006636 ! unsaturated fatty acid biosynthetic process
created_by: dgf
creation_date: 2011-12-14T07:48:26Z

[Term]
id: GO:2001280
name: positive regulation of unsaturated fatty acid biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of unsaturated fatty acid biosynthetic process." [GO:0006636]
synonym: "positive regulation of fatty acid desaturation" RELATED [GOC:obol]
synonym: "positive regulation of polyunsaturated fatty acid biosynthesis" RELATED [GOC:obol]
synonym: "positive regulation of unsaturated fatty acid anabolism" EXACT [GOC:obol]
synonym: "positive regulation of unsaturated fatty acid biosynthesis" EXACT [GOC:obol]
synonym: "positive regulation of unsaturated fatty acid formation" EXACT [GOC:obol]
synonym: "positive regulation of unsaturated fatty acid synthesis" EXACT [GOC:obol]
is_a: GO:0045723 ! positive regulation of fatty acid biosynthetic process
is_a: GO:2001279 ! regulation of unsaturated fatty acid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006636 ! unsaturated fatty acid biosynthetic process
relationship: positively_regulates GO:0006636 ! unsaturated fatty acid biosynthetic process
created_by: dgf
creation_date: 2011-12-14T07:48:33Z

[Term]
id: GO:2001281
name: regulation of muscle cell chemotaxis toward tendon cell
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of muscle cell chemotaxis toward tendon cell." [GOC:sart]
synonym: "regulation of muscle cell attraction" RELATED [GOC:obol]
synonym: "regulation of muscle cell chemotaxis towards tendon cell" EXACT [GOC:obol]
is_a: GO:0030334 ! regulation of cell migration
is_a: GO:0050920 ! regulation of chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0036061 ! muscle cell chemotaxis toward tendon cell
relationship: regulates GO:0036061 ! muscle cell chemotaxis toward tendon cell
created_by: rfoulger
creation_date: 2011-12-15T10:39:36Z

[Term]
id: GO:2001282
name: negative regulation of muscle cell chemotaxis toward tendon cell
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of a muscle cell towards a tendon cell in response to an external stimulus. For example, when the muscle cell arrives at the target tendon cell, migration is arrested so that attachments can be made between the cells." [GOC:sart, PMID:19793885, PMID:20404543]
synonym: "arrest of muscle cell chemotaxis" NARROW [GOC:bf, GOC:sart, PMID:19793885]
synonym: "negative regulation of muscle cell attraction" RELATED [GOC:obol]
synonym: "negative regulation of muscle cell chemotaxis towards tendon cell" EXACT [GOC:obol]
is_a: GO:0030336 ! negative regulation of cell migration
is_a: GO:0050922 ! negative regulation of chemotaxis
is_a: GO:2001281 ! regulation of muscle cell chemotaxis toward tendon cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0036061 ! muscle cell chemotaxis toward tendon cell
relationship: negatively_regulates GO:0036061 ! muscle cell chemotaxis toward tendon cell
created_by: rfoulger
creation_date: 2011-12-15T10:39:42Z

[Term]
id: GO:2001283
name: Roundabout signaling pathway involved in muscle cell chemotaxis toward tendon cell
namespace: biological_process
def: "Any Roundabout signaling pathway that is involved in the directed movement of a muscle cell towards a tendon cell in response to an external stimulus." [GOC:bf, GOC:obol, GOC:sart, PMID:19793885]
synonym: "ROBO signaling pathway involved in muscle cell attraction" RELATED [GOC:obol]
synonym: "ROBO signaling pathway involved in muscle cell chemotaxis toward tendon cell" EXACT [GOC:obol]
synonym: "ROBO signaling pathway involved in muscle cell chemotaxis towards tendon cell" EXACT [GOC:obol]
synonym: "ROBO/SLIT signaling pathway involved in muscle cell attraction" RELATED [GOC:obol]
synonym: "ROBO/SLIT signaling pathway involved in muscle cell chemotaxis toward tendon cell" EXACT [GOC:obol]
synonym: "ROBO/SLIT signaling pathway involved in muscle cell chemotaxis towards tendon cell" EXACT [GOC:obol]
synonym: "Roundabout signaling pathway involved in muscle cell attraction" RELATED [GOC:obol]
synonym: "Roundabout signaling pathway involved in muscle cell chemotaxis towards tendon cell" EXACT [GOC:obol]
synonym: "Roundabout signalling pathway involved in muscle cell attraction" RELATED [GOC:obol]
synonym: "Roundabout signalling pathway involved in muscle cell chemotaxis toward tendon cell" EXACT [GOC:obol]
synonym: "Roundabout signalling pathway involved in muscle cell chemotaxis towards tendon cell" EXACT [GOC:obol]
is_a: GO:0035385 ! Roundabout signaling pathway
intersection_of: GO:0035385 ! Roundabout signaling pathway
intersection_of: part_of GO:0036061 ! muscle cell chemotaxis toward tendon cell
relationship: part_of GO:0036061 ! muscle cell chemotaxis toward tendon cell
created_by: rfoulger
creation_date: 2011-12-15T10:42:03Z

[Term]
id: GO:2001284
name: regulation of BMP secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of BMP secretion." [GOC:sart]
synonym: "regulation of BMP protein secretion" EXACT [GOC:obol]
synonym: "regulation of bone morphogenetic protein secretion" EXACT [GOC:obol]
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0023051 ! regulation of signaling
is_a: GO:0050708 ! regulation of protein secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0038055 ! BMP secretion
relationship: regulates GO:0038055 ! BMP secretion
created_by: rfoulger
creation_date: 2011-12-15T02:15:28Z

[Term]
id: GO:2001285
name: negative regulation of BMP secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of BMP secretion." [GOC:sart]
synonym: "negative regulation of BMP protein secretion" EXACT [GOC:obol]
synonym: "negative regulation of bone morphogenetic protein secretion" EXACT [GOC:obol]
is_a: GO:0010648 ! negative regulation of cell communication
is_a: GO:0023057 ! negative regulation of signaling
is_a: GO:0050709 ! negative regulation of protein secretion
is_a: GO:2001284 ! regulation of BMP secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0038055 ! BMP secretion
relationship: negatively_regulates GO:0038055 ! BMP secretion
created_by: rfoulger
creation_date: 2011-12-15T02:15:36Z

[Term]
id: GO:2001286
name: regulation of caveolin-mediated endocytosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of caveolin-mediated endocytosis." [GOC:obol]
synonym: "regulation of caveolae-dependent endocytosis" EXACT [GOC:obol]
synonym: "regulation of caveolae-mediated endocytosis" EXACT [GOC:obol]
synonym: "regulation of caveolin-dependent endocytosis" EXACT [GOC:obol]
is_a: GO:0048259 ! regulation of receptor-mediated endocytosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072584 ! caveolin-mediated endocytosis
relationship: regulates GO:0072584 ! caveolin-mediated endocytosis
created_by: yaf
creation_date: 2011-12-15T04:13:19Z

[Term]
id: GO:2001287
name: negative regulation of caveolin-mediated endocytosis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of caveolin-mediated endocytosis." [GOC:obol]
synonym: "negative regulation of caveolae-dependent endocytosis" EXACT [GOC:obol]
synonym: "negative regulation of caveolae-mediated endocytosis" EXACT [GOC:obol]
synonym: "negative regulation of caveolin-dependent endocytosis" EXACT [GOC:obol]
is_a: GO:0048261 ! negative regulation of receptor-mediated endocytosis
is_a: GO:2001286 ! regulation of caveolin-mediated endocytosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072584 ! caveolin-mediated endocytosis
relationship: negatively_regulates GO:0072584 ! caveolin-mediated endocytosis
created_by: yaf
creation_date: 2011-12-15T04:13:27Z

[Term]
id: GO:2001288
name: positive regulation of caveolin-mediated endocytosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of caveolin-mediated endocytosis." [GOC:obol]
synonym: "positive regulation of caveolae-dependent endocytosis" EXACT [GOC:obol]
synonym: "positive regulation of caveolae-mediated endocytosis" EXACT [GOC:obol]
synonym: "positive regulation of caveolin-dependent endocytosis" EXACT [GOC:obol]
is_a: GO:0048260 ! positive regulation of receptor-mediated endocytosis
is_a: GO:2001286 ! regulation of caveolin-mediated endocytosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072584 ! caveolin-mediated endocytosis
relationship: positively_regulates GO:0072584 ! caveolin-mediated endocytosis
created_by: yaf
creation_date: 2011-12-15T04:13:32Z

[Term]
id: GO:2001289
name: lipid X metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lipid X, 2,3-diacylglucosamine 1-phosphate." [GOC:obol]
synonym: "2,3-Bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate metabolic process" RELATED [GOC:obol]
synonym: "2,3-Bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate metabolism" RELATED [GOC:obol]
synonym: "2,3-Bis(beta-hydoroxymyristoyl)-beta-D-glucosaminyl 1-phosphate metabolic process" RELATED [GOC:obol]
synonym: "2,3-Bis(beta-hydoroxymyristoyl)-beta-D-glucosaminyl 1-phosphate metabolism" RELATED [GOC:obol]
synonym: "2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-{[(3R)-3-hydroxytetradecanoyl]amino}-1-O-phosphono-alpha-D-glucopyranose metabolic process" EXACT [GOC:obol]
synonym: "2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-{[(3R)-3-hydroxytetradecanoyl]amino}-1-O-phosphono-alpha-D-glucopyranose metabolism" EXACT [GOC:obol]
synonym: "Lipid X metabolic process" EXACT [GOC:obol]
synonym: "Lipid X metabolism" EXACT [GOC:obol]
synonym: "lipid X metabolism" EXACT [GOC:obol]
is_a: GO:0006040 ! amino sugar metabolic process
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
created_by: tanyaberardini
creation_date: 2012-01-13T11:28:58Z

[Term]
id: GO:2001290
name: hydroperoxide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a hydroperoxide." [CHEBI:35923, GOC:rs, PMID:15917183, PMID:18084891]
synonym: "hydroperoxide metabolism" EXACT [GOC:obol]
is_a: GO:0044237 ! cellular metabolic process
created_by: pr
creation_date: 2012-02-09T03:35:37Z

[Term]
id: GO:2001291
name: codeine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving codeine, an alkaloid found in the opium poppy, Papaver somniferum var. album. Codeine has analgesic, anti-tussive and anti-diarrhoeal properties." [CHEBI:16714, GOC:yaf]
synonym: "codeine metabolism" EXACT [GOC:obol]
is_a: GO:0033076 ! isoquinoline alkaloid metabolic process
is_a: GO:0097164 ! ammonium ion metabolic process
is_a: GO:1901376 ! organic heteropentacyclic compound metabolic process
created_by: pr
creation_date: 2012-02-14T01:10:03Z

[Term]
id: GO:2001292
name: codeine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of codeine, an alkaloid found in the opium poppy, Papaver somniferum var. album. Codeine has analgesic, anti-tussive and anti-diarrhoeal properties." [CHEBI:16714, GOC:yaf, UniPathway:UPA00318]
synonym: "codeine breakdown" EXACT [GOC:obol]
synonym: "codeine catabolism" EXACT [GOC:obol]
synonym: "codeine degradation" EXACT [GOC:obol]
is_a: GO:0071274 ! isoquinoline alkaloid catabolic process
is_a: GO:1901377 ! organic heteropentacyclic compound catabolic process
is_a: GO:2001291 ! codeine metabolic process
created_by: pr
creation_date: 2012-02-14T01:10:09Z

[Term]
id: GO:2001293
name: malonyl-CoA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving malonyl-CoA, the S-malonyl derivative of coenzyme A." [CHEBI:15531, GOC:yaf, PMID:11902724, PMID:15726818, PMID:18981598]
synonym: "malonyl-CoA metabolism" EXACT [GOC:obol]
is_a: GO:0015936 ! coenzyme A metabolic process
is_a: GO:0035337 ! fatty-acyl-CoA metabolic process
created_by: pr
creation_date: 2012-02-14T02:23:11Z

[Term]
id: GO:2001294
name: malonyl-CoA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of malonyl-CoA, the S-malonyl derivative of coenzyme A." [CHEBI:15531, GOC:yaf]
synonym: "malonyl-CoA breakdown" EXACT [GOC:obol]
synonym: "malonyl-CoA catabolism" EXACT [GOC:obol]
synonym: "malonyl-CoA degradation" EXACT [GOC:obol]
is_a: GO:0015938 ! coenzyme A catabolic process
is_a: GO:0036115 ! fatty-acyl-CoA catabolic process
is_a: GO:2001293 ! malonyl-CoA metabolic process
created_by: pr
creation_date: 2012-02-14T02:23:17Z

[Term]
id: GO:2001295
name: malonyl-CoA biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of malonyl-CoA, the S-malonyl derivative of coenzyme A." [CHEBI:15531, GOC:yaf, UniPathway:UPA00655]
synonym: "malonyl-CoA anabolism" EXACT [GOC:obol]
synonym: "malonyl-CoA biosynthesis" EXACT [GOC:obol]
synonym: "malonyl-CoA formation" EXACT [GOC:obol]
synonym: "malonyl-CoA synthesis" EXACT [GOC:obol]
is_a: GO:0015937 ! coenzyme A biosynthetic process
is_a: GO:0046949 ! fatty-acyl-CoA biosynthetic process
is_a: GO:2001293 ! malonyl-CoA metabolic process
created_by: pr
creation_date: 2012-02-14T02:23:21Z

[Term]
id: GO:2001296
name: N(omega)-methyl-L-arginine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving N(omega)-methyl-L-arginine." [CHEBI:28229, GOC:rs, PMID:10510241]
synonym: "N(omega)-methyl-L-arginine metabolism" EXACT [GOC:obol]
is_a: GO:0006575 ! cellular modified amino acid metabolic process
is_a: GO:1901605 ! alpha-amino acid metabolic process
created_by: pr
creation_date: 2012-02-14T03:38:16Z

[Term]
id: GO:2001297
name: N(omega)-methyl-L-arginine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of N(omega)-methyl-L-arginine." [CHEBI:28229, GOC:rs, PMID:10510241]
synonym: "N(omega)-methyl-L-arginine breakdown" EXACT [GOC:obol]
synonym: "N(omega)-methyl-L-arginine catabolism" EXACT [GOC:obol]
synonym: "N(omega)-methyl-L-arginine degradation" EXACT [GOC:obol]
is_a: GO:0042219 ! cellular modified amino acid catabolic process
is_a: GO:1901606 ! alpha-amino acid catabolic process
is_a: GO:2001296 ! N(omega)-methyl-L-arginine metabolic process
created_by: pr
creation_date: 2012-02-14T03:38:21Z

[Term]
id: GO:2001298
name: N(omega),N(omega)-dimethyl-L-arginine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving N(omega),N(omega)-dimethyl-L-arginine, a methyl-L-arginine having two methyl groups both attached to the primary amino moiety of the guanidino group." [CHEBI:17929, GOC:rs, PMID:10510241]
synonym: "N(omega),N(omega)-dimethyl-L-arginine metabolism" EXACT [GOC:obol]
is_a: GO:0006575 ! cellular modified amino acid metabolic process
is_a: GO:1901605 ! alpha-amino acid metabolic process
created_by: pr
creation_date: 2012-02-14T03:39:59Z

[Term]
id: GO:2001299
name: N(omega),N(omega)-dimethyl-L-arginine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of N(omega),N(omega)-dimethyl-L-arginine, a methyl-L-arginine having two methyl groups both attached to the primary amino moiety of the guanidino group." [CHEBI:17929, GOC:rs, PMID:10510241]
synonym: "N(omega),N(omega)-dimethyl-L-arginine breakdown" EXACT [GOC:obol]
synonym: "N(omega),N(omega)-dimethyl-L-arginine catabolism" EXACT [GOC:obol]
synonym: "N(omega),N(omega)-dimethyl-L-arginine degradation" EXACT [GOC:obol]
is_a: GO:0042219 ! cellular modified amino acid catabolic process
is_a: GO:1901606 ! alpha-amino acid catabolic process
is_a: GO:2001298 ! N(omega),N(omega)-dimethyl-L-arginine metabolic process
created_by: pr
creation_date: 2012-02-14T03:40:03Z

[Term]
id: GO:2001300
name: lipoxin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a lipoxin. A lipoxin is a non-classic eicosanoid and signalling molecule that has four conjugated double bonds and is derived from arachidonic acid." [CHEBI:6497, GOC:mw]
synonym: "lipoxin metabolism" EXACT [GOC:obol]
is_a: GO:0006690 ! icosanoid metabolic process
is_a: GO:0033559 ! unsaturated fatty acid metabolic process
created_by: rfoulger
creation_date: 2012-03-07T11:11:08Z

[Term]
id: GO:2001301
name: lipoxin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a lipoxin. A lipoxin is a non-classic eicosanoid and signalling molecule that has four conjugated double bonds and is derived from arachidonic acid." [CHEBI:6497, GOC:mw]
synonym: "lipoxin anabolism" EXACT [GOC:obol]
synonym: "lipoxin biosynthesis" EXACT [GOC:obol]
synonym: "lipoxin formation" EXACT [GOC:obol]
synonym: "lipoxin synthesis" EXACT [GOC:obol]
is_a: GO:0006636 ! unsaturated fatty acid biosynthetic process
is_a: GO:0046456 ! icosanoid biosynthetic process
is_a: GO:2001300 ! lipoxin metabolic process
created_by: rfoulger
creation_date: 2012-03-07T11:11:13Z

[Term]
id: GO:2001302
name: lipoxin A4 metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lipoxin A4. Lipoxin A4 is a C20 hydroxy fatty acid having (5S)-, (6R)- and (15S)-hydroxy groups as well as (7E)- (9E)-, (11Z)- and (13E)-double bonds." [CHEBI:6498, GOC:mw]
synonym: "lipoxin A4 metabolism" EXACT [GOC:obol]
synonym: "LXA4 metabolic process" EXACT [GOC:obol]
synonym: "LXA4 metabolism" EXACT [GOC:obol]
is_a: GO:0001676 ! long-chain fatty acid metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process
is_a: GO:2001300 ! lipoxin metabolic process
created_by: rfoulger
creation_date: 2012-03-07T11:13:12Z

[Term]
id: GO:2001303
name: lipoxin A4 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lipoxin A4. Lipoxin A4 is a C20 hydroxy fatty acid having (5S)-, (6R)- and (15S)-hydroxy groups as well as (7E)- (9E)-, (11Z)- and (13E)-double bonds." [CHEBI:6498, GOC:mw]
synonym: "lipoxin A4 anabolism" EXACT [GOC:obol]
synonym: "lipoxin A4 biosynthesis" EXACT [GOC:obol]
synonym: "lipoxin A4 formation" EXACT [GOC:obol]
synonym: "lipoxin A4 synthesis" EXACT [GOC:obol]
synonym: "LXA4 anabolism" EXACT [GOC:obol]
synonym: "LXA4 biosynthesis" EXACT [GOC:obol]
synonym: "LXA4 biosynthetic process" EXACT [GOC:obol]
synonym: "LXA4 formation" EXACT [GOC:obol]
synonym: "LXA4 synthesis" EXACT [GOC:obol]
is_a: GO:0042759 ! long-chain fatty acid biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process
is_a: GO:2001301 ! lipoxin biosynthetic process
is_a: GO:2001302 ! lipoxin A4 metabolic process
created_by: rfoulger
creation_date: 2012-03-07T11:13:18Z

[Term]
id: GO:2001304
name: lipoxin B4 metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lipoxin B4. Lipoxin B4 is a C20 hydroxy fatty acid having (5S)-, (14R)- and (15S)-hydroxy groups as well as (6E)- (8Z)-, (10E)- and (12E)-double bonds." [CHEBI:6499, GOC:mw]
synonym: "lipoxin B4 metabolism" EXACT [GOC:obol]
synonym: "LXB4 metabolic process" EXACT [GOC:obol]
synonym: "LXB4 metabolism" EXACT [GOC:obol]
is_a: GO:0001676 ! long-chain fatty acid metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process
is_a: GO:2001300 ! lipoxin metabolic process
created_by: rfoulger
creation_date: 2012-03-07T11:14:58Z

[Term]
id: GO:2001305
name: xanthone-containing compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a xanthone-containing compound." [CHEBI:51149, GOC:di]
synonym: "xanthone metabolism" NARROW [CHEBI:37647]
synonym: "xanthone-containing compound metabolism" EXACT [GOC:obol]
synonym: "xanthones metabolic process" EXACT [GOC:obol]
synonym: "xanthones metabolism" EXACT [GOC:obol]
is_a: GO:0042180 ! cellular ketone metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
created_by: rfoulger
creation_date: 2012-03-14T10:35:38Z

[Term]
id: GO:2001306
name: lipoxin B4 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lipoxin B4. Lipoxin B4 is a C20 hydroxy fatty acid having (5S)-, (14R)- and (15S)-hydroxy groups as well as (6E)- (8Z)-, (10E)- and (12E)-double bonds." [CHEBI:6499, GOC:mw]
synonym: "lipoxin B4 anabolism" EXACT [GOC:obol]
synonym: "lipoxin B4 biosynthesis" EXACT [GOC:obol]
synonym: "lipoxin B4 formation" EXACT [GOC:obol]
synonym: "lipoxin B4 synthesis" EXACT [GOC:obol]
synonym: "LXB4 anabolism" EXACT [GOC:obol]
synonym: "LXB4 biosynthesis" EXACT [GOC:obol]
synonym: "LXB4 biosynthetic process" EXACT [GOC:obol]
synonym: "LXB4 formation" EXACT [GOC:obol]
synonym: "LXB4 synthesis" EXACT [GOC:obol]
is_a: GO:0042759 ! long-chain fatty acid biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process
is_a: GO:2001301 ! lipoxin biosynthetic process
is_a: GO:2001304 ! lipoxin B4 metabolic process
created_by: rfoulger
creation_date: 2012-03-07T11:15:04Z

[Term]
id: GO:2001307
name: xanthone-containing compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a xanthone-containing compound." [CHEBI:51149, GOC:di]
synonym: "xanthone biosynthesis" NARROW [CHEBI:37647]
synonym: "xanthone biosynthetic process" NARROW [CHEBI:37647]
synonym: "xanthone-containing compound anabolism" EXACT [GOC:obol]
synonym: "xanthone-containing compound biosynthesis" EXACT [GOC:obol]
synonym: "xanthone-containing compound formation" EXACT [GOC:obol]
synonym: "xanthone-containing compound synthesis" EXACT [GOC:obol]
synonym: "xanthones anabolism" EXACT [GOC:obol]
synonym: "xanthones biosynthesis" EXACT [GOC:obol]
synonym: "xanthones biosynthetic process" EXACT [GOC:obol]
synonym: "xanthones formation" EXACT [GOC:obol]
synonym: "xanthones synthesis" EXACT [GOC:obol]
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:2001305 ! xanthone-containing compound metabolic process
created_by: rfoulger
creation_date: 2012-03-14T10:35:44Z

[Term]
id: GO:2001308
name: gliotoxin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the epipolythiodioxopiperazine gliotoxin, a poisonous substance produced by some species of fungi." [CHEBI:299453, CHEBI:5385, GOC:di, PMID:16333108, PMID:17574915, PMID:18272357]
synonym: "gliotoxin metabolism" EXACT [GOC:obol]
is_a: GO:0006518 ! peptide metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0043385 ! mycotoxin metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
created_by: pr
creation_date: 2012-03-15T03:42:10Z

[Term]
id: GO:2001309
name: gliotoxin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the epipolythiodioxopiperazine gliotoxin, a poisonous substance produced by some species of fungi." [CHEBI:299453, CHEBI:5385, GOC:di, PMID:16333108, PMID:17574915, PMID:18272357]
synonym: "gliotoxin breakdown" EXACT [GOC:obol]
synonym: "gliotoxin catabolism" EXACT [GOC:obol]
synonym: "gliotoxin degradation" EXACT [GOC:obol]
is_a: GO:0043171 ! peptide catabolic process
is_a: GO:0043387 ! mycotoxin catabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:2001308 ! gliotoxin metabolic process
created_by: pr
creation_date: 2012-03-15T03:42:14Z

[Term]
id: GO:2001310
name: gliotoxin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the epipolythiodioxopiperazine gliotoxin, a poisonous substance produced by some species of fungi." [CHEBI:299453, CHEBI:5385, GOC:di, PMID:16333108, PMID:17574915, PMID:18272357]
synonym: "gliotoxin anabolism" EXACT [GOC:obol]
synonym: "gliotoxin biosynthesis" EXACT [GOC:obol]
synonym: "gliotoxin formation" EXACT [GOC:obol]
synonym: "gliotoxin synthesis" EXACT [GOC:obol]
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0043043 ! peptide biosynthetic process
is_a: GO:0043386 ! mycotoxin biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:2001308 ! gliotoxin metabolic process
created_by: pr
creation_date: 2012-03-15T03:42:18Z

[Term]
id: GO:2001311
name: lysobisphosphatidic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a lysobisphosphatidic acid. A lysobisphosphatidic acid is a lysophosphatidic acid having the unusual property of a phosphodiester moiety linked to positions sn-1 and sn1' of glycerol; and two additional fatty acids esterified to the glycerol head group." [CHEBI:60815, GOC:mw]
synonym: "bis(monoacylglycerol) hydrogen phosphate (BMP) metabolic process" EXACT [GOC:obol]
synonym: "bis(monoacylglycerol) hydrogen phosphate (BMP) metabolism" EXACT [GOC:obol]
synonym: "bis(monoacylglycerol) hydrogen phosphate metabolic process" EXACT [GOC:obol]
synonym: "bis(monoacylglycerol) hydrogen phosphate metabolism" EXACT [GOC:obol]
synonym: "LBPA metabolic process" EXACT [GOC:obol]
synonym: "LBPA metabolism" EXACT [GOC:obol]
synonym: "lysobisphosphatidic acid metabolism" EXACT [GOC:obol]
is_a: GO:0006650 ! glycerophospholipid metabolic process
is_a: GO:0052646 ! alditol phosphate metabolic process
created_by: rfoulger
creation_date: 2012-03-16T09:31:27Z

[Term]
id: GO:2001312
name: lysobisphosphatidic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a lysobisphosphatidic acid. A lysobisphosphatidic acid is a lysophosphatidic acid having the unusual property of a phosphodiester moiety linked to positions sn-1 and sn1' of glycerol; and two additional fatty acids esterified to the glycerol head group." [CHEBI:60815, GOC:mw]
synonym: "bis(monoacylglycerol) hydrogen phosphate (BMP) anabolism" EXACT [GOC:obol]
synonym: "bis(monoacylglycerol) hydrogen phosphate (BMP) biosynthesis" EXACT [GOC:obol]
synonym: "bis(monoacylglycerol) hydrogen phosphate (BMP) biosynthetic process" EXACT [GOC:obol]
synonym: "bis(monoacylglycerol) hydrogen phosphate (BMP) formation" EXACT [GOC:obol]
synonym: "bis(monoacylglycerol) hydrogen phosphate (BMP) synthesis" EXACT [GOC:obol]
synonym: "bis(monoacylglycerol) hydrogen phosphate anabolism" EXACT [GOC:obol]
synonym: "bis(monoacylglycerol) hydrogen phosphate biosynthesis" EXACT [GOC:obol]
synonym: "bis(monoacylglycerol) hydrogen phosphate biosynthetic process" EXACT [GOC:obol]
synonym: "bis(monoacylglycerol) hydrogen phosphate formation" EXACT [GOC:obol]
synonym: "bis(monoacylglycerol) hydrogen phosphate synthesis" EXACT [GOC:obol]
synonym: "LBPA anabolism" EXACT [GOC:obol]
synonym: "LBPA biosynthesis" EXACT [GOC:obol]
synonym: "LBPA biosynthetic process" EXACT [GOC:obol]
synonym: "LBPA formation" EXACT [GOC:obol]
synonym: "LBPA synthesis" EXACT [GOC:obol]
synonym: "lysobisphosphatidic acid anabolism" EXACT [GOC:obol]
synonym: "lysobisphosphatidic acid biosynthesis" EXACT [GOC:obol]
synonym: "lysobisphosphatidic acid formation" EXACT [GOC:obol]
synonym: "lysobisphosphatidic acid synthesis" EXACT [GOC:obol]
is_a: GO:0046474 ! glycerophospholipid biosynthetic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process
is_a: GO:2001311 ! lysobisphosphatidic acid metabolic process
created_by: rfoulger
creation_date: 2012-03-16T09:31:31Z

[Term]
id: GO:2001313
name: UDP-4-deoxy-4-formamido-beta-L-arabinopyranose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a UDP-4-deoxy-4-formamido-beta-L-arabinopyranose." [CHEBI:47027, GOC:yaf]
synonym: "UDP-4-deoxy-4-formamido-beta-L-arabinopyranose metabolism" EXACT [GOC:obol]
is_a: GO:0006040 ! amino sugar metabolic process
is_a: GO:0009225 ! nucleotide-sugar metabolic process
created_by: pr
creation_date: 2012-03-22T01:19:54Z

[Term]
id: GO:2001314
name: UDP-4-deoxy-4-formamido-beta-L-arabinopyranose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a UDP-4-deoxy-4-formamido-beta-L-arabinopyranose." [CHEBI:47027, GOC:yaf]
synonym: "UDP-4-deoxy-4-formamido-beta-L-arabinopyranose breakdown" EXACT [GOC:obol]
synonym: "UDP-4-deoxy-4-formamido-beta-L-arabinopyranose catabolism" EXACT [GOC:obol]
synonym: "UDP-4-deoxy-4-formamido-beta-L-arabinopyranose degradation" EXACT [GOC:obol]
is_a: GO:0009227 ! nucleotide-sugar catabolic process
is_a: GO:0046348 ! amino sugar catabolic process
is_a: GO:2001313 ! UDP-4-deoxy-4-formamido-beta-L-arabinopyranose metabolic process
created_by: pr
creation_date: 2012-03-22T01:20:01Z

[Term]
id: GO:2001315
name: UDP-4-deoxy-4-formamido-beta-L-arabinopyranose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a UDP-4-deoxy-4-formamido-beta-L-arabinopyranose." [CHEBI:47027, GOC:yaf, UniPathway:UPA00032]
synonym: "UDP-4-deoxy-4-formamido-beta-L-arabinopyranose anabolism" EXACT [GOC:obol]
synonym: "UDP-4-deoxy-4-formamido-beta-L-arabinopyranose biosynthesis" EXACT [GOC:obol]
synonym: "UDP-4-deoxy-4-formamido-beta-L-arabinopyranose formation" EXACT [GOC:obol]
synonym: "UDP-4-deoxy-4-formamido-beta-L-arabinopyranose synthesis" EXACT [GOC:obol]
is_a: GO:0009226 ! nucleotide-sugar biosynthetic process
is_a: GO:0046349 ! amino sugar biosynthetic process
is_a: GO:2001313 ! UDP-4-deoxy-4-formamido-beta-L-arabinopyranose metabolic process
created_by: pr
creation_date: 2012-03-22T01:20:05Z

[Term]
id: GO:2001316
name: kojic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving kojic acid." [CHEBI:43572, GOC:di]
synonym: "5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one metabolic process" EXACT [CHEBI:43572, GOC:obol]
synonym: "5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one metabolism" EXACT [CHEBI:43572, GOC:obol]
synonym: "C6H6O4 metabolic process" RELATED [CHEBI:43572, GOC:obol]
synonym: "C6H6O4 metabolism" RELATED [CHEBI:43572, GOC:obol]
synonym: "kojic acid metabolism" EXACT [GOC:obol]
is_a: GO:0034308 ! primary alcohol metabolic process
is_a: GO:0042180 ! cellular ketone metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
created_by: rfoulger
creation_date: 2012-04-18T09:22:42Z

[Term]
id: GO:2001317
name: kojic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of kojic acid." [CHEBI:43572, GOC:di]
synonym: "5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism" EXACT [CHEBI:43572, GOC:obol]
synonym: "5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis" EXACT [CHEBI:43572, GOC:obol]
synonym: "5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process" EXACT [CHEBI:43572, GOC:obol]
synonym: "5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation" EXACT [CHEBI:43572, GOC:obol]
synonym: "5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis" EXACT [CHEBI:43572, GOC:obol]
synonym: "C6H6O4 anabolism" RELATED [CHEBI:43572, GOC:obol]
synonym: "C6H6O4 biosynthesis" RELATED [CHEBI:43572, GOC:obol]
synonym: "C6H6O4 biosynthetic process" RELATED [CHEBI:43572, GOC:obol]
synonym: "C6H6O4 formation" RELATED [CHEBI:43572, GOC:obol]
synonym: "C6H6O4 synthesis" RELATED [CHEBI:43572, GOC:obol]
synonym: "kojic acid anabolism" EXACT [GOC:obol]
synonym: "kojic acid biosynthesis" EXACT [GOC:obol]
synonym: "kojic acid formation" EXACT [GOC:obol]
synonym: "kojic acid synthesis" EXACT [GOC:obol]
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0034309 ! primary alcohol biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:2001316 ! kojic acid metabolic process
created_by: rfoulger
creation_date: 2012-04-18T09:22:46Z

[Typedef]
id: ends_during
name: ends_during
namespace: external
xref: RO:0002093

[Typedef]
id: happens_during
name: happens_during
namespace: external
xref: RO:0002092
is_transitive: true
is_a: ends_during ! ends_during

[Typedef]
id: has_part
name: has_part
namespace: external
xref: BFO:0000051
is_transitive: true

[Typedef]
id: negatively_regulates
name: negatively regulates
namespace: external
xref: RO:0002212
is_a: regulates ! regulates
transitive_over: part_of ! part of

[Typedef]
id: never_in_taxon
name: never_in_taxon
namespace: external
xref: RO:0002161
expand_assertion_to: "Class: ?X DisjointWith: RO_0002162 some ?Y" []
is_metadata_tag: true
is_class_level: true

[Typedef]
id: occurs_in
name: occurs in
namespace: external
xref: BFO:0000066
holds_over_chain: part_of occurs_in
transitive_over: part_of ! part of

[Typedef]
id: part_of
name: part of
namespace: external
xref: BFO:0000050
is_transitive: true
inverse_of: has_part ! has_part

[Typedef]
id: positively_regulates
name: positively regulates
namespace: external
xref: RO:0002213
holds_over_chain: negatively_regulates negatively_regulates
is_a: regulates ! regulates
transitive_over: part_of ! part of

[Typedef]
id: regulates
name: regulates
namespace: external
xref: RO:0002211
is_transitive: true
transitive_over: part_of ! part of

[Typedef]
id: starts_during
name: starts_during
namespace: external
xref: RO:0002091